## Database ID URL or Descriptions # BioGrid 4262925 2 # EcoGene EG13636 rzpD # FUNCTION RZPD_ECOLI Necessary for host cell lysis. It is believed to code for an endopeptidase that cleaves the amino-carboxyl cross-link between the diaminopimelic acid and D-alanine residues in the murein component of the bacterial cell wall (By similarity). {ECO 0000250}. # GO_function GO:0008233 peptidase activity; IEA:UniProtKB-KW. # GO_process GO:0019076 viral release from host cell; IEA:InterPro. # GO_process GO:0019835 cytolysis; IEA:UniProtKB-KW. # GO_process GO:0042742 defense response to bacterium; IEA:UniProtKB-KW. # GOslim_function GO:0008233 peptidase activity # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0040011 locomotion # GOslim_process GO:0044403 symbiosis, encompassing mutualism through parasitism # InterPro IPR004929 i-spanin # KEGG_Brite ko01000 Enzymes # MISCELLANEOUS RZPD_ECOLI Encoded by the cryptic lambdoid prophage DLP12. # Organism RZPD_ECOLI Escherichia coli (strain K12) # PATRIC 32116278 VBIEscCol129921_0579 # PIR B64788 B64788 # Pfam PF03245 Phage_lysis # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Prophage Rz endopeptidase RzpD {ECO 0000305} # RefSeq NP_415088 NC_000913.3 # RefSeq WP_000092242 NZ_CP014270.1 # SEQUENCE CAUTION Sequence=AAB40752.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # eggNOG ENOG4105SZK Bacteria # eggNOG ENOG4111VX3 LUCA BLAST swissprot:RZPD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RZPD_ECOLI BioCyc ECOL316407:JW5079-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5079-MONOMER BioCyc EcoCyc:G6311-MONOMER http://biocyc.org/getid?id=EcoCyc:G6311-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.4.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 ENZYME 3.4.-.- http://enzyme.expasy.org/EC/3.4.-.- EchoBASE EB3400 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3400 EcoGene EG13636 http://www.ecogene.org/geneInfo.php?eg_id=EG13636 EnsemblBacteria AAC73657 http://www.ensemblgenomes.org/id/AAC73657 EnsemblBacteria AAC73657 http://www.ensemblgenomes.org/id/AAC73657 EnsemblBacteria BAE76331 http://www.ensemblgenomes.org/id/BAE76331 EnsemblBacteria BAE76331 http://www.ensemblgenomes.org/id/BAE76331 EnsemblBacteria BAE76331 http://www.ensemblgenomes.org/id/BAE76331 EnsemblBacteria b0556 http://www.ensemblgenomes.org/id/b0556 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GO_process GO:0019076 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019076 GO_process GO:0019835 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019835 GO_process GO:0042742 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042742 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0040011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011 GOslim_process GO:0044403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403 GeneID 945929 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945929 HOGENOM HOG000119352 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000119352&db=HOGENOM6 InParanoid P75719 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75719 IntEnz 3.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4 InterPro IPR004929 http://www.ebi.ac.uk/interpro/entry/IPR004929 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5079 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5079 KEGG_Gene eco:b0556 http://www.genome.jp/dbget-bin/www_bget?eco:b0556 KEGG_Orthology KO:K14744 http://www.genome.jp/dbget-bin/www_bget?KO:K14744 OMA NQCISAN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NQCISAN PSORT swissprot:RZPD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RZPD_ECOLI PSORT-B swissprot:RZPD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RZPD_ECOLI PSORT2 swissprot:RZPD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RZPD_ECOLI Pfam PF03245 http://pfam.xfam.org/family/PF03245 Phobius swissprot:RZPD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RZPD_ECOLI PhylomeDB P75719 http://phylomedb.org/?seqid=P75719 ProteinModelPortal P75719 http://www.proteinmodelportal.org/query/uniprot/P75719 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415088 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415088 RefSeq WP_000092242 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000092242 SMR P75719 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75719 STRING 511145.b0556 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0556&targetmode=cogs UniProtKB RZPD_ECOLI http://www.uniprot.org/uniprot/RZPD_ECOLI UniProtKB-AC P75719 http://www.uniprot.org/uniprot/P75719 charge swissprot:RZPD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RZPD_ECOLI eggNOG ENOG4105SZK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105SZK eggNOG ENOG4111VX3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111VX3 epestfind swissprot:RZPD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RZPD_ECOLI garnier swissprot:RZPD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RZPD_ECOLI helixturnhelix swissprot:RZPD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RZPD_ECOLI hmoment swissprot:RZPD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RZPD_ECOLI iep swissprot:RZPD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RZPD_ECOLI inforesidue swissprot:RZPD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RZPD_ECOLI octanol swissprot:RZPD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RZPD_ECOLI pepcoil swissprot:RZPD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RZPD_ECOLI pepdigest swissprot:RZPD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RZPD_ECOLI pepinfo swissprot:RZPD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RZPD_ECOLI pepnet swissprot:RZPD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RZPD_ECOLI pepstats swissprot:RZPD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RZPD_ECOLI pepwheel swissprot:RZPD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RZPD_ECOLI pepwindow swissprot:RZPD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RZPD_ECOLI sigcleave swissprot:RZPD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RZPD_ECOLI ## Database ID URL or Descriptions # AltName ACP_ECOLI Cytosolic-activating factor # AltName ACP_ECOLI Fatty acid synthase acyl carrier protein # BioGrid 4263360 478 # EcoGene EG50003 acpP # FUNCTION ACP_ECOLI Carrier of the growing fatty acid chain in fatty acid biosynthesis. # GO_component GO:0005737 cytoplasm; IDA:UniProtKB. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000035 acyl binding; IDA:EcoliWiki. # GO_function GO:0000036 ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process; IDA:EcoliWiki. # GO_function GO:0031177 phosphopantetheine binding; IMP:EcoliWiki. # GO_process GO:0006633 fatty acid biosynthetic process; IMP:EcoliWiki. # GO_process GO:0008610 lipid biosynthetic process; IMP:EcoliWiki. # GO_process GO:0009245 lipid A biosynthetic process; IMP:EcoliWiki. # GO_process GO:0042493 response to drug; IMP:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.1200.10 -; 1. # HAMAP MF_01217 Acyl_carrier # INTERACTION ACP_ECOLI O32591 espP (xeno); NbExp=2; IntAct=EBI-542566, EBI-852989; P0A7A7 plsB; NbExp=3; IntAct=EBI-542566, EBI-542961; P0AG24 spoT; NbExp=5; IntAct=EBI-542566, EBI-543228; P0A8Z3 ybgC; NbExp=6; IntAct=EBI-542566, EBI-543276; # IntAct P0A6A8 41 # InterPro IPR003231 Acyl_carrier # InterPro IPR006162 Ppantetheine_attach_site # InterPro IPR009081 PP-bd_ACP # Organism ACP_ECOLI Escherichia coli (strain K12) # PATHWAY Lipid metabolism; fatty acid biosynthesis. {ECO:0000255|HAMAP-Rule MF_01217}. # PATRIC 32117429 VBIEscCol129921_1137 # PDB 1ACP NMR; -; A=2-78 # PDB 1L0H X-ray; 2.00 A; A=1-77 # PDB 1L0I X-ray; 1.20 A; A=1-78 # PDB 1T8K X-ray; 1.10 A; A=2-78 # PDB 2FAC X-ray; 1.76 A; A/B=2-78 # PDB 2FAD X-ray; 1.60 A; A/B=2-78 # PDB 2FAE X-ray; 1.55 A; A/B=2-78 # PDB 2FHS X-ray; 2.70 A; C=1-78 # PDB 2K92 NMR; -; A=2-78 # PDB 2K93 NMR; -; A=2-78 # PDB 2K94 NMR; -; A=2-78 # PDB 3EJB X-ray; 2.00 A; A/C/E/G=1-78 # PDB 3EJD X-ray; 2.10 A; A/C/E/G=1-78 # PDB 3EJE X-ray; 2.10 A; A/C/E/G=1-78 # PDB 3NY7 X-ray; 1.92 A; B=1-78 # PIR C42147 AYEC # PROSITE PS00012 PHOSPHOPANTETHEINE # PROSITE PS50075 ACP_DOMAIN # PTM ACP_ECOLI 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group. # Pfam PF00550 PP-binding # ProDom PD000887 PD000887 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Acyl carrier protein {ECO:0000255|HAMAP-Rule MF_01217} # RefSeq NP_415612 NC_000913.3 # RefSeq WP_000103754 NZ_LN832404.1 # SIMILARITY Contains 1 acyl carrier domain. {ECO:0000255|HAMAP- Rule MF_01217}. # SUBCELLULAR LOCATION ACP_ECOLI Cytoplasm. # SUBUNIT Interacts with MukB. {ECO:0000269|PubMed 20921377}. # SUPFAM SSF47336 SSF47336 # TIGRFAMs TIGR00517 acyl_carrier # eggNOG COG0236 LUCA BLAST swissprot:ACP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ACP_ECOLI BioCyc BTHE:EG50003-MONOMER http://biocyc.org/getid?id=BTHE:EG50003-MONOMER BioCyc ECOL316407:JW1080-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1080-MONOMER BioCyc EcoCyc:EG50003-MONOMER http://biocyc.org/getid?id=EcoCyc:EG50003-MONOMER BioCyc MetaCyc:EG50003-MONOMER http://biocyc.org/getid?id=MetaCyc:EG50003-MONOMER BioCyc SHIGELLA:EG50003-MONOMER http://biocyc.org/getid?id=SHIGELLA:EG50003-MONOMER BioCyc SYNEL:EG50003-MONOMER http://biocyc.org/getid?id=SYNEL:EG50003-MONOMER COG COG0236 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0236 DIP DIP-29374N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-29374N DOI 10.1002/prot.340080411 http://dx.doi.org/10.1002/prot.340080411 DOI 10.1021/bi00416a046 http://dx.doi.org/10.1021/bi00416a046 DOI 10.1038/351759a0 http://dx.doi.org/10.1038/351759a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bst021202s http://dx.doi.org/10.1042/bst021202s DOI 10.1073/pnas.1008678107 http://dx.doi.org/10.1073/pnas.1008678107 DOI 10.1073/pnas.91.23.11027 http://dx.doi.org/10.1073/pnas.91.23.11027 DOI 10.1074/jbc.270.38.22229 http://dx.doi.org/10.1074/jbc.270.38.22229 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1432-1033.1988.tb14159.x http://dx.doi.org/10.1111/j.1432-1033.1988.tb14159.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DisProt DP00416 http://www.disprot.org/protein.php?id=DP00416 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M84991 http://www.ebi.ac.uk/ena/data/view/M84991 EMBL S65033 http://www.ebi.ac.uk/ena/data/view/S65033 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL Z34979 http://www.ebi.ac.uk/ena/data/view/Z34979 EchoBASE EB4297 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4297 EcoGene EG50003 http://www.ecogene.org/geneInfo.php?eg_id=EG50003 EnsemblBacteria AAC74178 http://www.ensemblgenomes.org/id/AAC74178 EnsemblBacteria AAC74178 http://www.ensemblgenomes.org/id/AAC74178 EnsemblBacteria BAA35902 http://www.ensemblgenomes.org/id/BAA35902 EnsemblBacteria BAA35902 http://www.ensemblgenomes.org/id/BAA35902 EnsemblBacteria BAA35902 http://www.ensemblgenomes.org/id/BAA35902 EnsemblBacteria b1094 http://www.ensemblgenomes.org/id/b1094 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000035 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000035 GO_function GO:0000036 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000036 GO_function GO:0031177 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031177 GO_process GO:0006633 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006633 GO_process GO:0008610 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008610 GO_process GO:0009245 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009245 GO_process GO:0042493 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.1200.10 http://www.cathdb.info/version/latest/superfamily/1.10.1200.10 GeneID 5551779 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5551779 GeneID 944805 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944805 HAMAP MF_01217 http://hamap.expasy.org/unirule/MF_01217 HOGENOM HOG000178184 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000178184&db=HOGENOM6 InParanoid P0A6A8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6A8 IntAct P0A6A8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6A8* InterPro IPR003231 http://www.ebi.ac.uk/interpro/entry/IPR003231 InterPro IPR006162 http://www.ebi.ac.uk/interpro/entry/IPR006162 InterPro IPR009081 http://www.ebi.ac.uk/interpro/entry/IPR009081 KEGG_Gene ecj:JW1080 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1080 KEGG_Gene eco:b1094 http://www.genome.jp/dbget-bin/www_bget?eco:b1094 KEGG_Orthology KO:K02078 http://www.genome.jp/dbget-bin/www_bget?KO:K02078 MINT MINT-1231626 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1231626 OMA IKPESSF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IKPESSF PDB 1ACP http://www.ebi.ac.uk/pdbe-srv/view/entry/1ACP PDB 1L0H http://www.ebi.ac.uk/pdbe-srv/view/entry/1L0H PDB 1L0I http://www.ebi.ac.uk/pdbe-srv/view/entry/1L0I PDB 1T8K http://www.ebi.ac.uk/pdbe-srv/view/entry/1T8K PDB 2FAC http://www.ebi.ac.uk/pdbe-srv/view/entry/2FAC PDB 2FAD http://www.ebi.ac.uk/pdbe-srv/view/entry/2FAD PDB 2FAE http://www.ebi.ac.uk/pdbe-srv/view/entry/2FAE PDB 2FHS http://www.ebi.ac.uk/pdbe-srv/view/entry/2FHS PDB 2K92 http://www.ebi.ac.uk/pdbe-srv/view/entry/2K92 PDB 2K93 http://www.ebi.ac.uk/pdbe-srv/view/entry/2K93 PDB 2K94 http://www.ebi.ac.uk/pdbe-srv/view/entry/2K94 PDB 3EJB http://www.ebi.ac.uk/pdbe-srv/view/entry/3EJB PDB 3EJD http://www.ebi.ac.uk/pdbe-srv/view/entry/3EJD PDB 3EJE http://www.ebi.ac.uk/pdbe-srv/view/entry/3EJE PDB 3NY7 http://www.ebi.ac.uk/pdbe-srv/view/entry/3NY7 PDBsum 1ACP http://www.ebi.ac.uk/pdbsum/1ACP PDBsum 1L0H http://www.ebi.ac.uk/pdbsum/1L0H PDBsum 1L0I http://www.ebi.ac.uk/pdbsum/1L0I PDBsum 1T8K http://www.ebi.ac.uk/pdbsum/1T8K PDBsum 2FAC http://www.ebi.ac.uk/pdbsum/2FAC PDBsum 2FAD http://www.ebi.ac.uk/pdbsum/2FAD PDBsum 2FAE http://www.ebi.ac.uk/pdbsum/2FAE PDBsum 2FHS http://www.ebi.ac.uk/pdbsum/2FHS PDBsum 2K92 http://www.ebi.ac.uk/pdbsum/2K92 PDBsum 2K93 http://www.ebi.ac.uk/pdbsum/2K93 PDBsum 2K94 http://www.ebi.ac.uk/pdbsum/2K94 PDBsum 3EJB http://www.ebi.ac.uk/pdbsum/3EJB PDBsum 3EJD http://www.ebi.ac.uk/pdbsum/3EJD PDBsum 3EJE http://www.ebi.ac.uk/pdbsum/3EJE PDBsum 3NY7 http://www.ebi.ac.uk/pdbsum/3NY7 PROSITE PS00012 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00012 PROSITE PS50075 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50075 PSORT swissprot:ACP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ACP_ECOLI PSORT-B swissprot:ACP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ACP_ECOLI PSORT2 swissprot:ACP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ACP_ECOLI Pfam PF00550 http://pfam.xfam.org/family/PF00550 Phobius swissprot:ACP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ACP_ECOLI PhylomeDB P0A6A8 http://phylomedb.org/?seqid=P0A6A8 ProteinModelPortal P0A6A8 http://www.proteinmodelportal.org/query/uniprot/P0A6A8 PubMed 1556094 http://www.ncbi.nlm.nih.gov/pubmed/1556094 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2062368 http://www.ncbi.nlm.nih.gov/pubmed/2062368 PubMed 2091027 http://www.ncbi.nlm.nih.gov/pubmed/2091027 PubMed 20921377 http://www.ncbi.nlm.nih.gov/pubmed/20921377 PubMed 3056520 http://www.ncbi.nlm.nih.gov/pubmed/3056520 PubMed 3402450 http://www.ncbi.nlm.nih.gov/pubmed/3402450 PubMed 3549687 http://www.ncbi.nlm.nih.gov/pubmed/3549687 PubMed 4882206 http://www.ncbi.nlm.nih.gov/pubmed/4882206 PubMed 4882207 http://www.ncbi.nlm.nih.gov/pubmed/4882207 PubMed 7673201 http://www.ncbi.nlm.nih.gov/pubmed/7673201 PubMed 7972002 http://www.ncbi.nlm.nih.gov/pubmed/7972002 PubMed 8359454 http://www.ncbi.nlm.nih.gov/pubmed/8359454 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415612 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415612 RefSeq WP_000103754 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000103754 SMR P0A6A8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6A8 STRING 511145.b1094 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1094&targetmode=cogs STRING COG0236 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0236&targetmode=cogs SUPFAM SSF47336 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47336 TIGRFAMs TIGR00517 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00517 UniProtKB ACP_ECOLI http://www.uniprot.org/uniprot/ACP_ECOLI UniProtKB-AC P0A6A8 http://www.uniprot.org/uniprot/P0A6A8 charge swissprot:ACP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ACP_ECOLI eggNOG COG0236 http://eggnogapi.embl.de/nog_data/html/tree/COG0236 epestfind swissprot:ACP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ACP_ECOLI garnier swissprot:ACP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ACP_ECOLI helixturnhelix swissprot:ACP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ACP_ECOLI hmoment swissprot:ACP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ACP_ECOLI iep swissprot:ACP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ACP_ECOLI inforesidue swissprot:ACP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ACP_ECOLI octanol swissprot:ACP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ACP_ECOLI pepcoil swissprot:ACP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ACP_ECOLI pepdigest swissprot:ACP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ACP_ECOLI pepinfo swissprot:ACP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ACP_ECOLI pepnet swissprot:ACP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ACP_ECOLI pepstats swissprot:ACP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ACP_ECOLI pepwheel swissprot:ACP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ACP_ECOLI pepwindow swissprot:ACP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ACP_ECOLI sigcleave swissprot:ACP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ACP_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES GPMA_ECOLI Kinetic parameters KM=190 uM for 2-PGA (at pH 7 and 30 degrees Celsius) {ECO 0000269|PubMed 10437801}; KM=200 uM for 3-PGA (at pH 7 and 30 degrees Celsius) {ECO 0000269|PubMed 10437801}; Note=Kcat is 330 sec(-1) for mutase with 3-PGA as substrate (at pH 7 and 30 degrees Celsius). Kcat is 220 sec(-1) for mutase with 2-PGA as substrate (at pH 7 and 30 degrees Celsius). {ECO 0000269|PubMed 10437801}; # CATALYTIC ACTIVITY GPMA_ECOLI 2-phospho-D-glycerate = 3-phospho-D-glycerate. {ECO 0000255|HAMAP-Rule MF_01039, ECO 0000269|PubMed 10437801}. # CDD cd07067 HP_PGM_like # DEVELOPMENTAL STAGE Peak expression observed in mid to late log phase. {ECO:0000269|PubMed 10437801}. # ENZYME REGULATION Strongly inhibited by vanadate. {ECO:0000269|PubMed 10437801}. # EcoGene EG11699 gpmA # FUNCTION GPMA_ECOLI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. {ECO 0000255|HAMAP-Rule MF_01039, ECO 0000269|PubMed 10437801}. # GO_component GO:0005737 cytoplasm; IDA:UniProtKB. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0046538 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity; IDA:EcoCyc. # GO_process GO:0006094 gluconeogenesis; IBA:GO_Central. # GO_process GO:0006096 glycolytic process; IBA:GO_Central. # GO_process GO:0043456 regulation of pentose-phosphate shunt; IBA:GO_Central. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.1240 -; 1. # HAMAP MF_01039 PGAM_GpmA # INDUCTION Regulated by the fur protein. {ECO:0000269|PubMed 11101675}. # IntAct P62707 15 # InterPro IPR001345 PG/BPGM_mutase_AS # InterPro IPR005952 Phosphogly_mut1 # InterPro IPR013078 His_Pase_superF_clade-1 # InterPro IPR029033 His_PPase_superfam # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00010 Glycolysis / Gluconeogenesis # KEGG_Pathway ko00260 Glycine, serine and threonine metabolism # KEGG_Pathway ko00680 Methane metabolism # MISCELLANEOUS Has a 10-fold higher specific activity than BPG- independent phosphoglycerate mutase. {ECO:0000269|PubMed 10437801}. # MISCELLANEOUS Inhibition by vanadate is a diagnostic test for discrimination between the cofactor-dependent (GpmA) and -independent (GpmI) phosphoglycerate mutases. {ECO:0000269|PubMed 10437801}. # Organism GPMA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11931 PTHR11931 # PATHWAY Carbohydrate degradation; glycolysis; pyruvate from D- glyceraldehyde 3-phosphate: step 3/5. {ECO 0000255|HAMAP- Rule:MF_01039}. # PATRIC 32116709 VBIEscCol129921_0780 # PDB 1E58 X-ray; 1.25 A; A=2-250 # PDB 1E59 X-ray; 1.30 A; A=2-250 # PIR C64811 C64811 # PROSITE PS00175 PG_MUTASE # Pfam PF00300 His_Phos_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GPMA_ECOLI 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase {ECO 0000255|HAMAP-Rule MF_01039, ECO 0000303|PubMed 10437801} # RefSeq NP_415276 NC_000913.3 # RefSeq WP_001295305 NZ_LN832404.1 # SIMILARITY Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. {ECO:0000255|HAMAP-Rule MF_01039}. # SMART SM00855 PGAM # SUBUNIT GPMA_ECOLI Homodimer. {ECO 0000255|HAMAP-Rule MF_01039, ECO 0000269|PubMed 10437801, ECO 0000269|PubMed 11038361, ECO 0000269|PubMed 11884145}. # SUPFAM SSF53254 SSF53254 # TIGRFAMs TIGR01258 pgm_1 # UniPathway UPA00109 UER00186 # eggNOG COG0588 LUCA # eggNOG ENOG4105DKJ Bacteria BLAST swissprot:GPMA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GPMA_ECOLI BioCyc ECOL316407:JW0738-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0738-MONOMER BioCyc EcoCyc:GPMA-MONOMER http://biocyc.org/getid?id=EcoCyc:GPMA-MONOMER BioCyc MetaCyc:GPMA-MONOMER http://biocyc.org/getid?id=MetaCyc:GPMA-MONOMER COG COG0588 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0588 DIP DIP-35899N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35899N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1998.1726 http://dx.doi.org/10.1006/jmbi.1998.1726 DOI 10.1006/jmbi.2002.5418 http://dx.doi.org/10.1006/jmbi.2002.5418 DOI 10.1016/S0014-5793(99)00910-2 http://dx.doi.org/10.1016/S0014-5793(99)00910-2 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M007318200 http://dx.doi.org/10.1074/jbc.M007318200 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/10.13.4045 http://dx.doi.org/10.1093/nar/10.13.4045 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.4.2.11 {ECO:0000255|HAMAP-Rule:MF_01039, ECO:0000269|PubMed:10437801} http://www.genome.jp/dbget-bin/www_bget?EC:5.4.2.11 {ECO:0000255|HAMAP-Rule:MF_01039, ECO:0000269|PubMed:10437801} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01591 http://www.ebi.ac.uk/ena/data/view/J01591 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 5.4.2.11 {ECO:0000255|HAMAP-Rule:MF_01039, ECO:0000269|PubMed:10437801} http://enzyme.expasy.org/EC/5.4.2.11 {ECO:0000255|HAMAP-Rule:MF_01039, ECO:0000269|PubMed:10437801} EchoBASE EB1650 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1650 EcoGene EG11699 http://www.ecogene.org/geneInfo.php?eg_id=EG11699 EnsemblBacteria AAC73842 http://www.ensemblgenomes.org/id/AAC73842 EnsemblBacteria AAC73842 http://www.ensemblgenomes.org/id/AAC73842 EnsemblBacteria BAA35417 http://www.ensemblgenomes.org/id/BAA35417 EnsemblBacteria BAA35417 http://www.ensemblgenomes.org/id/BAA35417 EnsemblBacteria BAA35417 http://www.ensemblgenomes.org/id/BAA35417 EnsemblBacteria b0755 http://www.ensemblgenomes.org/id/b0755 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0046538 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046538 GO_process GO:0006094 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006094 GO_process GO:0006096 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006096 GO_process GO:0043456 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043456 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.1240 http://www.cathdb.info/version/latest/superfamily/3.40.50.1240 GeneID 945068 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945068 HAMAP MF_01039 http://hamap.expasy.org/unirule/MF_01039 HOGENOM HOG000221682 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000221682&db=HOGENOM6 InParanoid P62707 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P62707 IntAct P62707 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P62707* IntEnz 5.4.2.11 {ECO:0000255|HAMAP-Rule:MF_01039, ECO:0000269|PubMed:10437801} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.4.2.11 {ECO:0000255|HAMAP-Rule:MF_01039, ECO:0000269|PubMed:10437801} InterPro IPR001345 http://www.ebi.ac.uk/interpro/entry/IPR001345 InterPro IPR005952 http://www.ebi.ac.uk/interpro/entry/IPR005952 InterPro IPR013078 http://www.ebi.ac.uk/interpro/entry/IPR013078 InterPro IPR029033 http://www.ebi.ac.uk/interpro/entry/IPR029033 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0738 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0738 KEGG_Gene eco:b0755 http://www.genome.jp/dbget-bin/www_bget?eco:b0755 KEGG_Orthology KO:K01834 http://www.genome.jp/dbget-bin/www_bget?KO:K01834 KEGG_Pathway ko00010 http://www.genome.jp/kegg-bin/show_pathway?ko00010 KEGG_Pathway ko00260 http://www.genome.jp/kegg-bin/show_pathway?ko00260 KEGG_Pathway ko00680 http://www.genome.jp/kegg-bin/show_pathway?ko00680 KEGG_Reaction rn:R01518 http://www.genome.jp/dbget-bin/www_bget?rn:R01518 MINT MINT-1227975 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1227975 OMA VKNQGKK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VKNQGKK PANTHER PTHR11931 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11931 PDB 1E58 http://www.ebi.ac.uk/pdbe-srv/view/entry/1E58 PDB 1E59 http://www.ebi.ac.uk/pdbe-srv/view/entry/1E59 PDBsum 1E58 http://www.ebi.ac.uk/pdbsum/1E58 PDBsum 1E59 http://www.ebi.ac.uk/pdbsum/1E59 PROSITE PS00175 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00175 PSORT swissprot:GPMA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GPMA_ECOLI PSORT-B swissprot:GPMA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GPMA_ECOLI PSORT2 swissprot:GPMA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GPMA_ECOLI Pfam PF00300 http://pfam.xfam.org/family/PF00300 Phobius swissprot:GPMA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GPMA_ECOLI PhylomeDB P62707 http://phylomedb.org/?seqid=P62707 ProteinModelPortal P62707 http://www.proteinmodelportal.org/query/uniprot/P62707 PubMed 10437801 http://www.ncbi.nlm.nih.gov/pubmed/10437801 PubMed 11038361 http://www.ncbi.nlm.nih.gov/pubmed/11038361 PubMed 11101675 http://www.ncbi.nlm.nih.gov/pubmed/11101675 PubMed 11884145 http://www.ncbi.nlm.nih.gov/pubmed/11884145 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 6125934 http://www.ncbi.nlm.nih.gov/pubmed/6125934 PubMed 8670822 http://www.ncbi.nlm.nih.gov/pubmed/8670822 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 RefSeq NP_415276 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415276 RefSeq WP_001295305 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295305 SMART SM00855 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00855 SMR P62707 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P62707 STRING 511145.b0755 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0755&targetmode=cogs STRING COG0588 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0588&targetmode=cogs SUPFAM SSF53254 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53254 SWISS-2DPAGE P62707 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P62707 TIGRFAMs TIGR01258 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01258 UniProtKB GPMA_ECOLI http://www.uniprot.org/uniprot/GPMA_ECOLI UniProtKB-AC P62707 http://www.uniprot.org/uniprot/P62707 charge swissprot:GPMA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GPMA_ECOLI eggNOG COG0588 http://eggnogapi.embl.de/nog_data/html/tree/COG0588 eggNOG ENOG4105DKJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DKJ epestfind swissprot:GPMA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GPMA_ECOLI garnier swissprot:GPMA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GPMA_ECOLI helixturnhelix swissprot:GPMA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GPMA_ECOLI hmoment swissprot:GPMA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GPMA_ECOLI iep swissprot:GPMA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GPMA_ECOLI inforesidue swissprot:GPMA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GPMA_ECOLI octanol swissprot:GPMA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GPMA_ECOLI pepcoil swissprot:GPMA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GPMA_ECOLI pepdigest swissprot:GPMA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GPMA_ECOLI pepinfo swissprot:GPMA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GPMA_ECOLI pepnet swissprot:GPMA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GPMA_ECOLI pepstats swissprot:GPMA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GPMA_ECOLI pepwheel swissprot:GPMA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GPMA_ECOLI pepwindow swissprot:GPMA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GPMA_ECOLI sigcleave swissprot:GPMA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GPMA_ECOLI ## Database ID URL or Descriptions # AltName PSPE_ECOLI Phage shock protein E # BIOPHYSICOCHEMICAL PROPERTIES PSPE_ECOLI Kinetic parameters KM=2.7 mM for thiosulfate (at pH 8.6 and at 25 degrees Celsius) {ECO 0000269|PubMed 11997041, ECO 0000269|PubMed 19088907}; KM=10 mM for dithiothreitol (at pH 8.6 and at 25 degrees Celsius) {ECO 0000269|PubMed 11997041, ECO 0000269|PubMed 19088907}; KM=32 mM for cyanide (at pH 8.6 and at 25 degrees Celsius) {ECO 0000269|PubMed 11997041, ECO 0000269|PubMed 19088907}; Vmax=410 umol/min/mg enzyme toward cyanide (at pH 8.6 and at 25 degrees Celsius) {ECO 0000269|PubMed 11997041, ECO 0000269|PubMed 19088907}; # BioGrid 4263234 400 # CATALYTIC ACTIVITY Thiosulfate + cyanide = sulfite + thiocyanate. {ECO:0000269|PubMed 11997041}. # ENZYME REGULATION PSPE_ECOLI Inhibited by thiosulfate above 100 mM, particularly at low cyanide concentrations (<5 mM). Inhibited by sodium sulfate or sodium chloride at 0.25 M which gives around 50% inhibition of rhodanese activity. Addition of sodium phosphate at the same concentration results in about 65% inhibition. Sulfite strongly inhibits PspE activity (1 mM sodium sulfite resulted in more than 50% inhibition of rhodanese activity). {ECO 0000269|PubMed 11997041, ECO 0000269|PubMed 19088907}. # EcoGene EG10780 pspE # FUNCTION PSPE_ECOLI The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions. PspE catalyzes the sulfur-transfer reaction from thiosulfate to cyanide, to form sulfite and thiocyanate. Also able to use dithiol (dithiothreitol) as an alternate sulfur acceptor. Also possesses a very low mercaptopyruvate sulfurtransferase activity. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_component GO:0042597 periplasmic space; IDA:EcoCyc. # GO_function GO:0004792 thiosulfate sulfurtransferase activity; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # Gene3D 3.40.250.10 -; 1. # INDUCTION PSPE_ECOLI By heat, ethanol, osmotic shock and infection by filamentous bacteriophages. Expression is positively regulated by cyclic AMP-cAMP receptor protein (cAMP-CRP). Expressed at higher levels during growth on glycerol, acetate or proline as carbon source relative to expression during growth on glucose. {ECO 0000269|PubMed 11997041, ECO 0000269|PubMed 1712397, ECO 0000269|PubMed 19088907}. # IntAct P23857 3 # InterPro IPR001763 Rhodanese-like_dom # InterPro IPR014323 Phageshock_PspE # MISCELLANEOUS PSPE_ECOLI Catalysis proceeds by a classical ping-pong bi-bi reaction mechanism, whereby a covalent enzyme-sulfur intermediate is formed on the active site cysteine. # Organism PSPE_ECOLI Escherichia coli (strain K12) # PATRIC 32117888 VBIEscCol129921_1364 # PDB 2JTQ NMR; -; A=20-104 # PDB 2JTR NMR; -; A=20-104 # PDB 2JTS NMR; -; A=20-104 # PIR S17125 S17125 # PROSITE PS50206 RHODANESE_3 # Pfam PF00581 Rhodanese # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PSPE_ECOLI Thiosulfate sulfurtransferase PspE # RefSeq NP_415824 NC_000913.3 # RefSeq WP_000473109 NZ_LN832404.1 # SIMILARITY Contains 1 rhodanese domain. {ECO:0000255|PROSITE- ProRule PRU00173}. # SMART SM00450 RHOD # SUBCELLULAR LOCATION PSPE_ECOLI Periplasm {ECO 0000269|PubMed 1712397}. # SUBUNIT Monomer. {ECO:0000269|PubMed 18355042}. # SUPFAM SSF52821 SSF52821 # TIGRFAMs TIGR02981 phageshock_pspE # eggNOG COG0607 LUCA # eggNOG ENOG4105K8Z Bacteria BLAST swissprot:PSPE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PSPE_ECOLI BioCyc ECOL316407:JW1301-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1301-MONOMER BioCyc EcoCyc:EG10780-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10780-MONOMER BioCyc MetaCyc:EG10780-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10780-MONOMER COG COG0607 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0607 DIP DIP-10591N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10591N DOI 10.1016/0022-2836(91)90379-K http://dx.doi.org/10.1016/0022-2836(91)90379-K DOI 10.1016/S0014-5793(02)02695-9 http://dx.doi.org/10.1016/S0014-5793(02)02695-9 DOI 10.1021/bi800039n http://dx.doi.org/10.1021/bi800039n DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1111/j.1574-6968.1998.tb13343.x http://dx.doi.org/10.1111/j.1574-6968.1998.tb13343.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.2174/1874285800802010018 http://dx.doi.org/10.2174/1874285800802010018 EC_number EC:2.8.1.1 http://www.genome.jp/dbget-bin/www_bget?EC:2.8.1.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X57560 http://www.ebi.ac.uk/ena/data/view/X57560 ENZYME 2.8.1.1 http://enzyme.expasy.org/EC/2.8.1.1 EchoBASE EB0773 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0773 EcoGene EG10780 http://www.ecogene.org/geneInfo.php?eg_id=EG10780 EnsemblBacteria AAC74390 http://www.ensemblgenomes.org/id/AAC74390 EnsemblBacteria AAC74390 http://www.ensemblgenomes.org/id/AAC74390 EnsemblBacteria BAA14877 http://www.ensemblgenomes.org/id/BAA14877 EnsemblBacteria BAA14877 http://www.ensemblgenomes.org/id/BAA14877 EnsemblBacteria BAA14877 http://www.ensemblgenomes.org/id/BAA14877 EnsemblBacteria b1308 http://www.ensemblgenomes.org/id/b1308 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0004792 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004792 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 Gene3D 3.40.250.10 http://www.cathdb.info/version/latest/superfamily/3.40.250.10 GeneID 945652 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945652 HOGENOM HOG000247776 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000247776&db=HOGENOM6 InParanoid P23857 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23857 IntAct P23857 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P23857* IntEnz 2.8.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.8.1.1 InterPro IPR001763 http://www.ebi.ac.uk/interpro/entry/IPR001763 InterPro IPR014323 http://www.ebi.ac.uk/interpro/entry/IPR014323 KEGG_Gene ecj:JW1301 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1301 KEGG_Gene eco:b1308 http://www.genome.jp/dbget-bin/www_bget?eco:b1308 KEGG_Orthology KO:K03972 http://www.genome.jp/dbget-bin/www_bget?KO:K03972 OMA ANEIWID http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ANEIWID PDB 2JTQ http://www.ebi.ac.uk/pdbe-srv/view/entry/2JTQ PDB 2JTR http://www.ebi.ac.uk/pdbe-srv/view/entry/2JTR PDB 2JTS http://www.ebi.ac.uk/pdbe-srv/view/entry/2JTS PDBsum 2JTQ http://www.ebi.ac.uk/pdbsum/2JTQ PDBsum 2JTR http://www.ebi.ac.uk/pdbsum/2JTR PDBsum 2JTS http://www.ebi.ac.uk/pdbsum/2JTS PROSITE PS50206 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50206 PSORT swissprot:PSPE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PSPE_ECOLI PSORT-B swissprot:PSPE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PSPE_ECOLI PSORT2 swissprot:PSPE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PSPE_ECOLI Pfam PF00581 http://pfam.xfam.org/family/PF00581 Phobius swissprot:PSPE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PSPE_ECOLI PhylomeDB P23857 http://phylomedb.org/?seqid=P23857 ProteinModelPortal P23857 http://www.proteinmodelportal.org/query/uniprot/P23857 PubMed 11997041 http://www.ncbi.nlm.nih.gov/pubmed/11997041 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1712397 http://www.ncbi.nlm.nih.gov/pubmed/1712397 PubMed 18355042 http://www.ncbi.nlm.nih.gov/pubmed/18355042 PubMed 19088907 http://www.ncbi.nlm.nih.gov/pubmed/19088907 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9868784 http://www.ncbi.nlm.nih.gov/pubmed/9868784 RefSeq NP_415824 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415824 RefSeq WP_000473109 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000473109 SMART SM00450 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00450 SMR P23857 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P23857 STRING 511145.b1308 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1308&targetmode=cogs STRING COG0607 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0607&targetmode=cogs SUPFAM SSF52821 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52821 TIGRFAMs TIGR02981 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02981 UniProtKB PSPE_ECOLI http://www.uniprot.org/uniprot/PSPE_ECOLI UniProtKB-AC P23857 http://www.uniprot.org/uniprot/P23857 charge swissprot:PSPE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PSPE_ECOLI eggNOG COG0607 http://eggnogapi.embl.de/nog_data/html/tree/COG0607 eggNOG ENOG4105K8Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K8Z epestfind swissprot:PSPE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PSPE_ECOLI garnier swissprot:PSPE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PSPE_ECOLI helixturnhelix swissprot:PSPE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PSPE_ECOLI hmoment swissprot:PSPE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PSPE_ECOLI iep swissprot:PSPE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PSPE_ECOLI inforesidue swissprot:PSPE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PSPE_ECOLI octanol swissprot:PSPE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PSPE_ECOLI pepcoil swissprot:PSPE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PSPE_ECOLI pepdigest swissprot:PSPE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PSPE_ECOLI pepinfo swissprot:PSPE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PSPE_ECOLI pepnet swissprot:PSPE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PSPE_ECOLI pepstats swissprot:PSPE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PSPE_ECOLI pepwheel swissprot:PSPE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PSPE_ECOLI pepwindow swissprot:PSPE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PSPE_ECOLI sigcleave swissprot:PSPE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PSPE_ECOLI ## Database ID URL or Descriptions # Organism YUBO_ECOLI Escherichia coli (strain K12) # PIR S07013 S07013 # RecName YUBO_ECOLI Uncharacterized protein YubO # RefSeq NP_061447 NC_002483.1 # RefSeq WP_000107542 NZ_CP014273.1 # RefSeq YP_008997965 NC_023315.1 BLAST swissprot:YUBO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YUBO_ECOLI DOI 10.1006/plas.1999.1390 http://dx.doi.org/10.1006/plas.1999.1390 DOI 10.1007/BF00261174 http://dx.doi.org/10.1007/BF00261174 EMBL AF106329 http://www.ebi.ac.uk/ena/data/view/AF106329 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL X17539 http://www.ebi.ac.uk/ena/data/view/X17539 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1263534 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263534 GeneID 18195074 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18195074 OMA KTVSYTI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KTVSYTI PSORT swissprot:YUBO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YUBO_ECOLI PSORT-B swissprot:YUBO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YUBO_ECOLI PSORT2 swissprot:YUBO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YUBO_ECOLI Phobius swissprot:YUBO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YUBO_ECOLI ProteinModelPortal Q02885 http://www.proteinmodelportal.org/query/uniprot/Q02885 PubMed 10366527 http://www.ncbi.nlm.nih.gov/pubmed/10366527 PubMed 2693941 http://www.ncbi.nlm.nih.gov/pubmed/2693941 RefSeq NP_061447 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061447 RefSeq WP_000107542 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000107542 RefSeq YP_008997965 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_008997965 UniProtKB YUBO_ECOLI http://www.uniprot.org/uniprot/YUBO_ECOLI UniProtKB-AC Q02885 http://www.uniprot.org/uniprot/Q02885 charge swissprot:YUBO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YUBO_ECOLI epestfind swissprot:YUBO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YUBO_ECOLI garnier swissprot:YUBO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YUBO_ECOLI helixturnhelix swissprot:YUBO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YUBO_ECOLI hmoment swissprot:YUBO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YUBO_ECOLI iep swissprot:YUBO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YUBO_ECOLI inforesidue swissprot:YUBO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YUBO_ECOLI octanol swissprot:YUBO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YUBO_ECOLI pepcoil swissprot:YUBO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YUBO_ECOLI pepdigest swissprot:YUBO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YUBO_ECOLI pepinfo swissprot:YUBO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YUBO_ECOLI pepnet swissprot:YUBO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YUBO_ECOLI pepstats swissprot:YUBO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YUBO_ECOLI pepwheel swissprot:YUBO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YUBO_ECOLI pepwindow swissprot:YUBO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YUBO_ECOLI sigcleave swissprot:YUBO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YUBO_ECOLI ## Database ID URL or Descriptions # BRENDA 4.2.1.20 2026 # BioGrid 4260129 9 # CATALYTIC ACTIVITY L-serine + 1-C-(indol-3-yl)glycerol 3- phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H(2)O. {ECO:0000255|HAMAP-Rule MF_00131}. # CDD cd04724 Tryptophan_synthase_alpha # EcoGene EG11024 trpA # FUNCTION TRPA_ECOLI The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004834 tryptophan synthase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0016829 lyase activity; IDA:EcoCyc. # GO_function GO:0030170 pyridoxal phosphate binding; IBA:GO_Central. # GO_process GO:0000162 tryptophan biosynthetic process; IMP:EcoliWiki. # GO_process GO:0008652 cellular amino acid biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0009073 aromatic amino acid family biosynthetic process; IMP:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.20.20.70 -; 1. # HAMAP MF_00131 Trp_synth_alpha # IntAct P0A877 6 # InterPro IPR002028 Trp_synthase_suA # InterPro IPR011060 RibuloseP-bd_barrel # InterPro IPR013785 Aldolase_TIM # InterPro IPR018204 Trp_synthase_alpha_AS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00260 Glycine, serine and threonine metabolism # KEGG_Pathway ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis # Organism TRPA_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-tryptophan biosynthesis; L- tryptophan from chorismate: step 5/5. {ECO 0000255|HAMAP- Rule:MF_00131}. # PATRIC 32117780 VBIEscCol129921_1310 # PDB 1V7Y X-ray; 2.50 A; A/B=1-268 # PDB 1WQ5 X-ray; 2.30 A; A/B=1-268 # PDB 1XC4 X-ray; 2.80 A; A/B=1-268 # PDB 1XCF X-ray; 1.80 A; A/B=1-268 # PIR E93746 TSECA # PROSITE PS00167 TRP_SYNTHASE_ALPHA # Pfam PF00290 Trp_syntA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Tryptophan synthase alpha chain {ECO:0000255|HAMAP-Rule MF_00131} # RefSeq NP_415776 NC_000913.3 # RefSeq WP_000443067 NZ_LN832404.1 # SIMILARITY Belongs to the TrpA family. {ECO:0000255|HAMAP- Rule MF_00131}. # SUBUNIT TRPA_ECOLI Tetramer of two alpha and two beta chains. # SUPFAM SSF51366 SSF51366 # TIGRFAMs TIGR00262 trpA # UniPathway UPA00035 UER00044 # eggNOG COG0159 LUCA # eggNOG ENOG4105F6H Bacteria BLAST swissprot:TRPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRPA_ECOLI BioCyc ECOL316407:JW1252-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1252-MONOMER BioCyc EcoCyc:TRYPSYN-APROTEIN http://biocyc.org/getid?id=EcoCyc:TRYPSYN-APROTEIN BioCyc MetaCyc:TRYPSYN-APROTEIN http://biocyc.org/getid?id=MetaCyc:TRYPSYN-APROTEIN COG COG0159 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0159 DIP DIP-35957N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35957N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1016/0300-9084(89)90089-8 http://dx.doi.org/10.1016/0300-9084(89)90089-8 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.76.10.5244 http://dx.doi.org/10.1073/pnas.76.10.5244 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/9.24.6647 http://dx.doi.org/10.1093/nar/9.24.6647 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DisProt DP00252 http://www.disprot.org/protein.php?id=DP00252 EC_number EC:4.2.1.20 {ECO:0000255|HAMAP-Rule:MF_00131} http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.20 {ECO:0000255|HAMAP-Rule:MF_00131} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01714 http://www.ebi.ac.uk/ena/data/view/J01714 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U23489 http://www.ebi.ac.uk/ena/data/view/U23489 EMBL U23490 http://www.ebi.ac.uk/ena/data/view/U23490 EMBL U23491 http://www.ebi.ac.uk/ena/data/view/U23491 EMBL U23492 http://www.ebi.ac.uk/ena/data/view/U23492 EMBL U23494 http://www.ebi.ac.uk/ena/data/view/U23494 EMBL U25417 http://www.ebi.ac.uk/ena/data/view/U25417 EMBL U25418 http://www.ebi.ac.uk/ena/data/view/U25418 EMBL U25419 http://www.ebi.ac.uk/ena/data/view/U25419 EMBL U25420 http://www.ebi.ac.uk/ena/data/view/U25420 EMBL U25421 http://www.ebi.ac.uk/ena/data/view/U25421 EMBL U25422 http://www.ebi.ac.uk/ena/data/view/U25422 EMBL V00364 http://www.ebi.ac.uk/ena/data/view/V00364 EMBL V00372 http://www.ebi.ac.uk/ena/data/view/V00372 EMBL X16698 http://www.ebi.ac.uk/ena/data/view/X16698 ENZYME 4.2.1.20 {ECO:0000255|HAMAP-Rule:MF_00131} http://enzyme.expasy.org/EC/4.2.1.20 {ECO:0000255|HAMAP-Rule:MF_00131} EchoBASE EB1017 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1017 EcoGene EG11024 http://www.ecogene.org/geneInfo.php?eg_id=EG11024 EnsemblBacteria AAC74342 http://www.ensemblgenomes.org/id/AAC74342 EnsemblBacteria AAC74342 http://www.ensemblgenomes.org/id/AAC74342 EnsemblBacteria BAA14792 http://www.ensemblgenomes.org/id/BAA14792 EnsemblBacteria BAA14792 http://www.ensemblgenomes.org/id/BAA14792 EnsemblBacteria BAA14792 http://www.ensemblgenomes.org/id/BAA14792 EnsemblBacteria b1260 http://www.ensemblgenomes.org/id/b1260 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004834 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004834 GO_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_process GO:0000162 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000162 GO_process GO:0008652 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008652 GO_process GO:0009073 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009073 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 946204 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946204 HAMAP MF_00131 http://hamap.expasy.org/unirule/MF_00131 HOGENOM HOG000223814 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000223814&db=HOGENOM6 InParanoid P0A877 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A877 IntAct P0A877 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A877* IntEnz 4.2.1.20 {ECO:0000255|HAMAP-Rule:MF_00131} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.20 {ECO:0000255|HAMAP-Rule:MF_00131} InterPro IPR002028 http://www.ebi.ac.uk/interpro/entry/IPR002028 InterPro IPR011060 http://www.ebi.ac.uk/interpro/entry/IPR011060 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR018204 http://www.ebi.ac.uk/interpro/entry/IPR018204 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1252 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1252 KEGG_Gene eco:b1260 http://www.genome.jp/dbget-bin/www_bget?eco:b1260 KEGG_Orthology KO:K01695 http://www.genome.jp/dbget-bin/www_bget?KO:K01695 KEGG_Pathway ko00260 http://www.genome.jp/kegg-bin/show_pathway?ko00260 KEGG_Pathway ko00400 http://www.genome.jp/kegg-bin/show_pathway?ko00400 KEGG_Reaction rn:R00674 http://www.genome.jp/dbget-bin/www_bget?rn:R00674 KEGG_Reaction rn:R02340 http://www.genome.jp/dbget-bin/www_bget?rn:R02340 KEGG_Reaction rn:R02722 http://www.genome.jp/dbget-bin/www_bget?rn:R02722 OMA DYNPHIP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DYNPHIP PDB 1V7Y http://www.ebi.ac.uk/pdbe-srv/view/entry/1V7Y PDB 1WQ5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1WQ5 PDB 1XC4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1XC4 PDB 1XCF http://www.ebi.ac.uk/pdbe-srv/view/entry/1XCF PDBsum 1V7Y http://www.ebi.ac.uk/pdbsum/1V7Y PDBsum 1WQ5 http://www.ebi.ac.uk/pdbsum/1WQ5 PDBsum 1XC4 http://www.ebi.ac.uk/pdbsum/1XC4 PDBsum 1XCF http://www.ebi.ac.uk/pdbsum/1XCF PROSITE PS00167 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00167 PSORT swissprot:TRPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRPA_ECOLI PSORT-B swissprot:TRPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRPA_ECOLI PSORT2 swissprot:TRPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRPA_ECOLI Pfam PF00290 http://pfam.xfam.org/family/PF00290 Phobius swissprot:TRPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRPA_ECOLI PhylomeDB P0A877 http://phylomedb.org/?seqid=P0A877 ProteinModelPortal P0A877 http://www.proteinmodelportal.org/query/uniprot/P0A877 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2502189 http://www.ncbi.nlm.nih.gov/pubmed/2502189 PubMed 388433 http://www.ncbi.nlm.nih.gov/pubmed/388433 PubMed 4863752 http://www.ncbi.nlm.nih.gov/pubmed/4863752 PubMed 7038627 http://www.ncbi.nlm.nih.gov/pubmed/7038627 PubMed 8095913 http://www.ncbi.nlm.nih.gov/pubmed/8095913 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_415776 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415776 RefSeq WP_000443067 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000443067 SMR P0A877 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A877 STRING 511145.b1260 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1260&targetmode=cogs STRING COG0159 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0159&targetmode=cogs SUPFAM SSF51366 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51366 SWISS-2DPAGE P0A877 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A877 TIGRFAMs TIGR00262 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00262 UniProtKB TRPA_ECOLI http://www.uniprot.org/uniprot/TRPA_ECOLI UniProtKB-AC P0A877 http://www.uniprot.org/uniprot/P0A877 charge swissprot:TRPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRPA_ECOLI eggNOG COG0159 http://eggnogapi.embl.de/nog_data/html/tree/COG0159 eggNOG ENOG4105F6H http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F6H epestfind swissprot:TRPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRPA_ECOLI garnier swissprot:TRPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRPA_ECOLI helixturnhelix swissprot:TRPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRPA_ECOLI hmoment swissprot:TRPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRPA_ECOLI iep swissprot:TRPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRPA_ECOLI inforesidue swissprot:TRPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRPA_ECOLI octanol swissprot:TRPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRPA_ECOLI pepcoil swissprot:TRPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRPA_ECOLI pepdigest swissprot:TRPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRPA_ECOLI pepinfo swissprot:TRPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRPA_ECOLI pepnet swissprot:TRPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRPA_ECOLI pepstats swissprot:TRPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRPA_ECOLI pepwheel swissprot:TRPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRPA_ECOLI pepwindow swissprot:TRPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRPA_ECOLI sigcleave swissprot:TRPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRPA_ECOLI ## Database ID URL or Descriptions # AltName RFAI_ECOLI Lipopolysaccharide 3-alpha-galactosyltransferase # BioGrid 4263412 183 # CATALYTIC ACTIVITY RFAI_ECOLI UDP-alpha-D-galactose + [lipopolysaccharide] = UDP + 3-alpha-D-galactosyl-[lipopolysaccharide]. # CAZy GT8 Glycosyltransferase Family 8 # EcoGene EG11352 rfaI # GO_function GO:0008918 lipopolysaccharide 3-alpha-galactosyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0047270 lipopolysaccharide glucosyltransferase II activity; IDA:EcoCyc. # GO_process GO:0009244 lipopolysaccharide core region biosynthetic process; IMP:EcoCyc. # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.90.550.10 -; 1. # IntAct P27128 3 # InterPro IPR002495 Glyco_trans_8 # InterPro IPR013645 Glyco_transf_8N # InterPro IPR029044 Nucleotide-diphossugar_trans # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01003 Glycosyltransferases # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # KEGG_Pathway ko00540 Lipopolysaccharide biosynthesis # Organism RFAI_ECOLI Escherichia coli (strain K12) # PATHWAY RFAI_ECOLI Bacterial outer membrane biogenesis; LPS core biosynthesis. # PATRIC 32122741 VBIEscCol129921_3747 # PIR C42982 C42982 # Pfam PF01501 Glyco_transf_8 # Pfam PF08437 Glyco_transf_8C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RFAI_ECOLI Lipopolysaccharide 1,3-galactosyltransferase # RefSeq NP_418084 NC_000913.3 # RefSeq WP_001188013 NZ_CP014272.1 # SIMILARITY Belongs to the glycosyltransferase 8 family. {ECO 0000305}. # SUPFAM SSF53448 SSF53448 # eggNOG COG1442 LUCA # eggNOG ENOG4106AH0 Bacteria BLAST swissprot:RFAI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RFAI_ECOLI BioCyc ECOL316407:JW3602-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3602-MONOMER BioCyc EcoCyc:EG11352-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11352-MONOMER BioCyc MetaCyc:EG11352-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11352-MONOMER COG CAZy: http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=CAZy: COG COG1442 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1442 COG GT8 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=GT8 DIP DIP-10670N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10670N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.4.1.44 http://www.genome.jp/dbget-bin/www_bget?EC:2.4.1.44 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M80599 http://www.ebi.ac.uk/ena/data/view/M80599 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.4.1.44 http://enzyme.expasy.org/EC/2.4.1.44 EchoBASE EB1327 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1327 EcoGene EG11352 http://www.ecogene.org/geneInfo.php?eg_id=EG11352 EnsemblBacteria AAC76651 http://www.ensemblgenomes.org/id/AAC76651 EnsemblBacteria AAC76651 http://www.ensemblgenomes.org/id/AAC76651 EnsemblBacteria BAE77665 http://www.ensemblgenomes.org/id/BAE77665 EnsemblBacteria BAE77665 http://www.ensemblgenomes.org/id/BAE77665 EnsemblBacteria BAE77665 http://www.ensemblgenomes.org/id/BAE77665 EnsemblBacteria b3627 http://www.ensemblgenomes.org/id/b3627 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008918 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008918 GO_function GO:0047270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047270 GO_process GO:0009244 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009244 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.90.550.10 http://www.cathdb.info/version/latest/superfamily/3.90.550.10 GeneID 948143 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948143 HOGENOM HOG000126190 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126190&db=HOGENOM6 InParanoid P27128 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P27128 IntAct P27128 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P27128* IntEnz 2.4.1.44 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.1.44 InterPro IPR002495 http://www.ebi.ac.uk/interpro/entry/IPR002495 InterPro IPR013645 http://www.ebi.ac.uk/interpro/entry/IPR013645 InterPro IPR029044 http://www.ebi.ac.uk/interpro/entry/IPR029044 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01003 http://www.genome.jp/dbget-bin/www_bget?ko01003 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Gene ecj:JW3602 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3602 KEGG_Gene eco:b3627 http://www.genome.jp/dbget-bin/www_bget?eco:b3627 KEGG_Orthology KO:K03275 http://www.genome.jp/dbget-bin/www_bget?KO:K03275 KEGG_Pathway ko00540 http://www.genome.jp/kegg-bin/show_pathway?ko00540 MINT MINT-1255919 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1255919 OMA IVHFCGG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IVHFCGG PSORT swissprot:RFAI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RFAI_ECOLI PSORT-B swissprot:RFAI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RFAI_ECOLI PSORT2 swissprot:RFAI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RFAI_ECOLI Pfam PF01501 http://pfam.xfam.org/family/PF01501 Pfam PF08437 http://pfam.xfam.org/family/PF08437 Phobius swissprot:RFAI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RFAI_ECOLI PhylomeDB P27128 http://phylomedb.org/?seqid=P27128 ProteinModelPortal P27128 http://www.proteinmodelportal.org/query/uniprot/P27128 PubMed 1624461 http://www.ncbi.nlm.nih.gov/pubmed/1624461 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418084 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418084 RefSeq WP_001188013 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001188013 STRING 511145.b3627 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3627&targetmode=cogs STRING CAZy: http://string-db.org/newstring_cgi/show_network_section.pl?identifier=CAZy:&targetmode=cogs STRING COG1442 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1442&targetmode=cogs STRING GT8 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=GT8&targetmode=cogs SUPFAM SSF53448 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53448 UniProtKB RFAI_ECOLI http://www.uniprot.org/uniprot/RFAI_ECOLI UniProtKB-AC P27128 http://www.uniprot.org/uniprot/P27128 charge swissprot:RFAI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RFAI_ECOLI eggNOG COG1442 http://eggnogapi.embl.de/nog_data/html/tree/COG1442 eggNOG ENOG4106AH0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106AH0 epestfind swissprot:RFAI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RFAI_ECOLI garnier swissprot:RFAI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RFAI_ECOLI helixturnhelix swissprot:RFAI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RFAI_ECOLI hmoment swissprot:RFAI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RFAI_ECOLI iep swissprot:RFAI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RFAI_ECOLI inforesidue swissprot:RFAI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RFAI_ECOLI octanol swissprot:RFAI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RFAI_ECOLI pepcoil swissprot:RFAI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RFAI_ECOLI pepdigest swissprot:RFAI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RFAI_ECOLI pepinfo swissprot:RFAI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RFAI_ECOLI pepnet swissprot:RFAI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RFAI_ECOLI pepstats swissprot:RFAI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RFAI_ECOLI pepwheel swissprot:RFAI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RFAI_ECOLI pepwindow swissprot:RFAI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RFAI_ECOLI sigcleave swissprot:RFAI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RFAI_ECOLI ## Database ID URL or Descriptions # BioGrid 4261950 14 # CATALYTIC ACTIVITY SDHB_ECOLI Succinate + a quinone = fumarate + a quinol. # CDD cd00207 fer2 # COFACTOR Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI 49601; Note=Binds 1 [2Fe-2S] cluster.; # COFACTOR Name=[3Fe-4S] cluster; Xref=ChEBI:CHEBI 21137; Note=Binds 1 [3Fe-4S] cluster.; # COFACTOR Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI 49883; Note=Binds 1 [4Fe-4S] cluster.; # EcoGene EG10932 sdhB # FUNCTION SDHB_ECOLI Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0045273 respiratory chain complex II; IBA:GO_Central. # GO_function GO:0000104 succinate dehydrogenase activity; IBA:GO_Central. # GO_function GO:0008177 succinate dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC. # GO_function GO:0009055 electron carrier activity; IMP:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051536 iron-sulfur cluster binding; IDA:EcoCyc. # GO_function GO:0051537 2 iron, 2 sulfur cluster binding; IMP:EcoCyc. # GO_function GO:0051538 3 iron, 4 sulfur cluster binding; IDA:EcoCyc. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IMP:EcoCyc. # GO_process GO:0006099 tricarboxylic acid cycle; IEA:UniProtKB-UniPathway. # GO_process GO:0009060 aerobic respiration; IEP:EcoCyc. # GO_process GO:0022904 respiratory electron transport chain; IBA:GO_Central. # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.10.20.30 -; 1. # INTERACTION SDHB_ECOLI P0AC41 sdhA; NbExp=2; IntAct=EBI-1035514, EBI-371263; # IntAct P07014 8 # InterPro IPR001041 2Fe-2S_ferredoxin-type # InterPro IPR004489 Succ_DH/fum_Rdtase_Fe-S # InterPro IPR009051 Helical_ferredxn # InterPro IPR012675 Beta-grasp_dom # InterPro IPR017896 4Fe4S_Fe-S-bd # InterPro IPR017900 4Fe4S_Fe_S_CS # InterPro IPR025192 Succ_DH/fum_Rdtase_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00020 Citrate cycle (TCA cycle) # KEGG_Pathway ko00190 Oxidative phosphorylation # KEGG_Pathway ko00623 Toluene degradation # KEGG_Pathway ko00650 Butanoate metabolism # KEGG_Pathway ko00720 Carbon fixation pathways in prokaryotes # Organism SDHB_ECOLI Escherichia coli (strain K12) # PATHWAY Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (bacterial route) step 1/1. # PATRIC 32116643 VBIEscCol129921_0754 # PDB 1NEK X-ray; 2.60 A; B=1-238 # PDB 1NEN X-ray; 2.90 A; B=1-238 # PDB 2ACZ X-ray; 3.10 A; B=1-238 # PDB 2AD0 Model; -; B=1-238 # PDB 2WDQ X-ray; 2.40 A; B/F/J=1-238 # PDB 2WDR X-ray; 3.20 A; B/F/J=1-238 # PDB 2WDV X-ray; 3.20 A; B/F/J=1-238 # PDB 2WP9 X-ray; 2.70 A; B/F/J=1-238 # PDB 2WS3 X-ray; 3.20 A; B/F/J=1-238 # PDB 2WU2 X-ray; 2.50 A; B/F/J=1-238 # PDB 2WU5 X-ray; 2.80 A; B/F/J=1-238 # PIR A28837 DEECSI # PROSITE PS00198 4FE4S_FER_1 # PROSITE PS51085 2FE2S_FER_2 # PROSITE PS51379 4FE4S_FER_2 # Pfam PF13085 Fer2_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SDHB_ECOLI Succinate dehydrogenase iron-sulfur subunit # RefSeq NP_415252 NC_000913.3 # RefSeq WP_001235254 NZ_LN832404.1 # SIMILARITY Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. {ECO 0000305}. # SIMILARITY Contains 1 2Fe-2S ferredoxin-type domain. {ECO:0000255|PROSITE-ProRule PRU00465}. # SIMILARITY Contains 1 4Fe-4S ferredoxin-type domain. {ECO:0000255|PROSITE-ProRule PRU00711}. # SUBCELLULAR LOCATION SDHB_ECOLI Cell inner membrane {ECO 0000269|PubMed 16079137}; Peripheral membrane protein {ECO 0000269|PubMed 16079137}. # SUBUNIT SDHB_ECOLI Part of an enzyme complex containing four subunits a flavoprotein, an iron-sulfur, cytochrome b-556, and a hydrophobic anchor protein. The complex forms trimers. {ECO 0000269|PubMed 12560550, ECO 0000269|PubMed 16079137, ECO 0000269|PubMed 16407191, ECO 0000269|PubMed 19710024}. # SUPFAM SSF46548 SSF46548 # SUPFAM SSF54292 SSF54292 # TIGRFAMs TIGR00384 dhsB # UniPathway UPA00223 UER01005 # eggNOG COG0479 LUCA # eggNOG ENOG4105E33 Bacteria BLAST swissprot:SDHB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SDHB_ECOLI BioCyc ECOL316407:JW0714-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0714-MONOMER BioCyc EcoCyc:SDH-FE-S http://biocyc.org/getid?id=EcoCyc:SDH-FE-S BioCyc MetaCyc:SDH-FE-S http://biocyc.org/getid?id=MetaCyc:SDH-FE-S COG COG0479 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0479 DIP DIP-10836N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10836N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2230507 http://dx.doi.org/10.1042/bj2230507 DOI 10.1074/jbc.M109.010058 http://dx.doi.org/10.1074/jbc.M109.010058 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1074/jbc.M508173200 http://dx.doi.org/10.1074/jbc.M508173200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1432-1033.1984.tb08199.x http://dx.doi.org/10.1111/j.1432-1033.1984.tb08199.x DOI 10.1126/science.1079605 http://dx.doi.org/10.1126/science.1079605 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.3.5.1 http://www.genome.jp/dbget-bin/www_bget?EC:1.3.5.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01619 http://www.ebi.ac.uk/ena/data/view/J01619 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X00661 http://www.ebi.ac.uk/ena/data/view/X00661 EMBL X01070 http://www.ebi.ac.uk/ena/data/view/X01070 ENZYME 1.3.5.1 http://enzyme.expasy.org/EC/1.3.5.1 EchoBASE EB0925 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0925 EcoGene EG10932 http://www.ecogene.org/geneInfo.php?eg_id=EG10932 EnsemblBacteria AAC73818 http://www.ensemblgenomes.org/id/AAC73818 EnsemblBacteria AAC73818 http://www.ensemblgenomes.org/id/AAC73818 EnsemblBacteria BAA35391 http://www.ensemblgenomes.org/id/BAA35391 EnsemblBacteria BAA35391 http://www.ensemblgenomes.org/id/BAA35391 EnsemblBacteria BAA35391 http://www.ensemblgenomes.org/id/BAA35391 EnsemblBacteria b0724 http://www.ensemblgenomes.org/id/b0724 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0045273 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045273 GO_function GO:0000104 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000104 GO_function GO:0008177 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008177 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051536 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051536 GO_function GO:0051537 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051537 GO_function GO:0051538 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051538 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0006099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006099 GO_process GO:0009060 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009060 GO_process GO:0022904 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022904 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.10.20.30 http://www.cathdb.info/version/latest/superfamily/3.10.20.30 GeneID 945300 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945300 HOGENOM HOG000160590 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000160590&db=HOGENOM6 InParanoid P07014 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P07014 IntAct P07014 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P07014* IntEnz 1.3.5.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.3.5.1 InterPro IPR001041 http://www.ebi.ac.uk/interpro/entry/IPR001041 InterPro IPR004489 http://www.ebi.ac.uk/interpro/entry/IPR004489 InterPro IPR009051 http://www.ebi.ac.uk/interpro/entry/IPR009051 InterPro IPR012675 http://www.ebi.ac.uk/interpro/entry/IPR012675 InterPro IPR017896 http://www.ebi.ac.uk/interpro/entry/IPR017896 InterPro IPR017900 http://www.ebi.ac.uk/interpro/entry/IPR017900 InterPro IPR025192 http://www.ebi.ac.uk/interpro/entry/IPR025192 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0714 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0714 KEGG_Gene eco:b0724 http://www.genome.jp/dbget-bin/www_bget?eco:b0724 KEGG_Orthology KO:K00240 http://www.genome.jp/dbget-bin/www_bget?KO:K00240 KEGG_Pathway ko00020 http://www.genome.jp/kegg-bin/show_pathway?ko00020 KEGG_Pathway ko00190 http://www.genome.jp/kegg-bin/show_pathway?ko00190 KEGG_Pathway ko00623 http://www.genome.jp/kegg-bin/show_pathway?ko00623 KEGG_Pathway ko00650 http://www.genome.jp/kegg-bin/show_pathway?ko00650 KEGG_Pathway ko00720 http://www.genome.jp/kegg-bin/show_pathway?ko00720 KEGG_Reaction rn:R00408 http://www.genome.jp/dbget-bin/www_bget?rn:R00408 KEGG_Reaction rn:R00412 http://www.genome.jp/dbget-bin/www_bget?rn:R00412 OMA DGQYFGP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DGQYFGP PDB 1NEK http://www.ebi.ac.uk/pdbe-srv/view/entry/1NEK PDB 1NEN http://www.ebi.ac.uk/pdbe-srv/view/entry/1NEN PDB 2ACZ http://www.ebi.ac.uk/pdbe-srv/view/entry/2ACZ PDB 2AD0 http://www.ebi.ac.uk/pdbe-srv/view/entry/2AD0 PDB 2WDQ http://www.ebi.ac.uk/pdbe-srv/view/entry/2WDQ PDB 2WDR http://www.ebi.ac.uk/pdbe-srv/view/entry/2WDR PDB 2WDV http://www.ebi.ac.uk/pdbe-srv/view/entry/2WDV PDB 2WP9 http://www.ebi.ac.uk/pdbe-srv/view/entry/2WP9 PDB 2WS3 http://www.ebi.ac.uk/pdbe-srv/view/entry/2WS3 PDB 2WU2 http://www.ebi.ac.uk/pdbe-srv/view/entry/2WU2 PDB 2WU5 http://www.ebi.ac.uk/pdbe-srv/view/entry/2WU5 PDBsum 1NEK http://www.ebi.ac.uk/pdbsum/1NEK PDBsum 1NEN http://www.ebi.ac.uk/pdbsum/1NEN PDBsum 2ACZ http://www.ebi.ac.uk/pdbsum/2ACZ PDBsum 2AD0 http://www.ebi.ac.uk/pdbsum/2AD0 PDBsum 2WDQ http://www.ebi.ac.uk/pdbsum/2WDQ PDBsum 2WDR http://www.ebi.ac.uk/pdbsum/2WDR PDBsum 2WDV http://www.ebi.ac.uk/pdbsum/2WDV PDBsum 2WP9 http://www.ebi.ac.uk/pdbsum/2WP9 PDBsum 2WS3 http://www.ebi.ac.uk/pdbsum/2WS3 PDBsum 2WU2 http://www.ebi.ac.uk/pdbsum/2WU2 PDBsum 2WU5 http://www.ebi.ac.uk/pdbsum/2WU5 PROSITE PS00198 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00198 PROSITE PS51085 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51085 PROSITE PS51379 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51379 PSORT swissprot:SDHB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SDHB_ECOLI PSORT-B swissprot:SDHB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SDHB_ECOLI PSORT2 swissprot:SDHB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SDHB_ECOLI Pfam PF13085 http://pfam.xfam.org/family/PF13085 Phobius swissprot:SDHB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SDHB_ECOLI PhylomeDB P07014 http://phylomedb.org/?seqid=P07014 ProteinModelPortal P07014 http://www.proteinmodelportal.org/query/uniprot/P07014 PubMed 12560550 http://www.ncbi.nlm.nih.gov/pubmed/12560550 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16407191 http://www.ncbi.nlm.nih.gov/pubmed/16407191 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19710024 http://www.ncbi.nlm.nih.gov/pubmed/19710024 PubMed 6376123 http://www.ncbi.nlm.nih.gov/pubmed/6376123 PubMed 6388571 http://www.ncbi.nlm.nih.gov/pubmed/6388571 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_415252 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415252 RefSeq WP_001235254 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001235254 SMR P07014 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P07014 STRING 511145.b0724 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0724&targetmode=cogs STRING COG0479 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0479&targetmode=cogs SUPFAM SSF46548 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46548 SUPFAM SSF54292 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54292 TIGRFAMs TIGR00384 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00384 UniProtKB SDHB_ECOLI http://www.uniprot.org/uniprot/SDHB_ECOLI UniProtKB-AC P07014 http://www.uniprot.org/uniprot/P07014 charge swissprot:SDHB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SDHB_ECOLI eggNOG COG0479 http://eggnogapi.embl.de/nog_data/html/tree/COG0479 eggNOG ENOG4105E33 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E33 epestfind swissprot:SDHB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SDHB_ECOLI garnier swissprot:SDHB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SDHB_ECOLI helixturnhelix swissprot:SDHB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SDHB_ECOLI hmoment swissprot:SDHB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SDHB_ECOLI iep swissprot:SDHB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SDHB_ECOLI inforesidue swissprot:SDHB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SDHB_ECOLI octanol swissprot:SDHB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SDHB_ECOLI pepcoil swissprot:SDHB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SDHB_ECOLI pepdigest swissprot:SDHB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SDHB_ECOLI pepinfo swissprot:SDHB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SDHB_ECOLI pepnet swissprot:SDHB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SDHB_ECOLI pepstats swissprot:SDHB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SDHB_ECOLI pepwheel swissprot:SDHB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SDHB_ECOLI pepwindow swissprot:SDHB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SDHB_ECOLI sigcleave swissprot:SDHB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SDHB_ECOLI ## Database ID URL or Descriptions # CDD cd00336 Ribosomal_L22 # EcoGene EG10882 rplV # FUNCTION RL22_ECOLI The globular domain of the protein is one of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that penetrates into the center of the 70S ribosome where it lines the wall of the exit tunnel. Removal of most of this hairpin (residues 85-95) does not prevent its incorporation into 70S ribosomes. Two of the hairpin residues (91 and 93) seem to be involved in translation elongation arrest of the SecM protein, as their replacement by larger amino acids alleviates the arrest. {ECO 0000269|PubMed 11893334, ECO 0000269|PubMed 13130133}. # FUNCTION RL22_ECOLI This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. {ECO 0000269|PubMed 7766155}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0022625 cytosolic large ribosomal subunit; IDA:EcoCyc. # GO_function GO:0003735 structural constituent of ribosome; IBA:GO_Central. # GO_function GO:0019843 rRNA binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006412 translation; IEA:UniProtKB-HAMAP. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_function GO:0019843 rRNA binding # GOslim_process GO:0006412 translation # GOslim_process GO:0008150 biological_process # Gene3D 3.90.470.10 -; 1. # HAMAP MF_01331_B Ribosomal_L22_B # INTERACTION RL22_ECOLI P17993 ubiG; NbExp=2; IntAct=EBI-542255, EBI-559367; # IntAct P61175 128 # InterPro IPR001063 Ribosomal_L22 # InterPro IPR005727 Ribosomal_L22_bac/chlpt-type # InterPro IPR018260 Ribosomal_L22/L17_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 M00179 Ribosome, archaea # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=12225.3; Method=MALDI; Range=1-110; Evidence={ECO:0000269|PubMed 10094780}; # MISCELLANEOUS RL22_ECOLI The wild-type allele (erythromycin sensitive) is dominant over the resistant allele, and is also dominant over the temperature-sensitive allele at both low and high temperatures. # Organism RL22_ECOLI Escherichia coli (strain K12) # PANTHER PTHR13501 PTHR13501 # PATRIC 32122062 VBIEscCol129921_3408 # PDB 2J28 EM; 8.00 A; S=1-110 # PDB 2RDO EM; 9.10 A; S=1-110 # PDB 3BBX EM; 10.00 A; S=1-110 # PDB 3J5L EM; 6.60 A; S=1-110 # PDB 3J7Z EM; 3.90 A; S=1-110 # PDB 3J8G EM; 5.00 A; S=1-110 # PDB 3J9Y EM; 3.90 A; S=1-110 # PDB 3J9Z EM; 3.60 A; LQ=1-110 # PDB 3JA1 EM; 3.60 A; LU=1-110 # PDB 3JBU EM; 3.64 A; s=1-110 # PDB 3JBV EM; 3.32 A; s=1-110 # PDB 3JCD EM; 3.70 A; S=1-110 # PDB 3JCE EM; 3.20 A; S=1-110 # PDB 3JCJ EM; 3.70 A; R=1-110 # PDB 3JCN EM; 4.60 A; S=1-110 # PDB 4CSU EM; 5.50 A; S=1-110 # PDB 4U1U X-ray; 2.95 A; BS/DS=1-110 # PDB 4U1V X-ray; 3.00 A; BS/DS=1-110 # PDB 4U20 X-ray; 2.90 A; BS/DS=1-110 # PDB 4U24 X-ray; 2.90 A; BS/DS=1-110 # PDB 4U25 X-ray; 2.90 A; BS/DS=1-110 # PDB 4U26 X-ray; 2.80 A; BS/DS=1-110 # PDB 4U27 X-ray; 2.80 A; BS/DS=1-110 # PDB 4UY8 EM; 3.80 A; S=1-110 # PDB 4V47 EM; 12.30 A; AQ=1-110 # PDB 4V48 EM; 11.50 A; AQ=1-110 # PDB 4V4H X-ray; 3.46 A; BS/DS=1-110 # PDB 4V4Q X-ray; 3.46 A; BS/DS=1-110 # PDB 4V4V EM; 15.00 A; BQ=5-110 # PDB 4V4W EM; 15.00 A; BQ=5-110 # PDB 4V50 X-ray; 3.22 A; BS/DS=1-110 # PDB 4V52 X-ray; 3.21 A; BS/DS=1-110 # PDB 4V53 X-ray; 3.54 A; BS/DS=1-110 # PDB 4V54 X-ray; 3.30 A; BS/DS=1-110 # PDB 4V55 X-ray; 4.00 A; BS/DS=1-110 # PDB 4V56 X-ray; 3.93 A; BS/DS=1-110 # PDB 4V57 X-ray; 3.50 A; BS/DS=1-110 # PDB 4V5B X-ray; 3.74 A; AS/CS=1-110 # PDB 4V5H EM; 5.80 A; BS=1-110 # PDB 4V5Y X-ray; 4.45 A; BS/DS=1-110 # PDB 4V64 X-ray; 3.50 A; BS/DS=1-110 # PDB 4V65 EM; 9.00 A; BL=1-110 # PDB 4V66 EM; 9.00 A; BL=1-110 # PDB 4V69 EM; 6.70 A; BS=1-110 # PDB 4V6C X-ray; 3.19 A; BS/DS=1-110 # PDB 4V6D X-ray; 3.81 A; BS/DS=1-110 # PDB 4V6E X-ray; 3.71 A; BS/DS=1-110 # PDB 4V6K EM; 8.25 A; AT=1-110 # PDB 4V6L EM; 13.20 A; BT=1-110 # PDB 4V6M EM; 7.10 A; BS=1-110 # PDB 4V6N EM; 12.10 A; AU=1-110 # PDB 4V6O EM; 14.70 A; BU=1-110 # PDB 4V6P EM; 13.50 A; BU=1-110 # PDB 4V6Q EM; 11.50 A; BU=1-110 # PDB 4V6R EM; 11.50 A; BU=1-110 # PDB 4V6S EM; 13.10 A; AU=1-110 # PDB 4V6T EM; 8.30 A; BS=1-110 # PDB 4V6V EM; 9.80 A; BW=1-110 # PDB 4V6Y EM; 12.00 A; BS=1-110 # PDB 4V6Z EM; 12.00 A; BS=1-110 # PDB 4V70 EM; 17.00 A; BS=1-110 # PDB 4V71 EM; 20.00 A; BS=1-110 # PDB 4V72 EM; 13.00 A; BS=1-110 # PDB 4V73 EM; 15.00 A; BS=1-110 # PDB 4V74 EM; 17.00 A; BS=1-110 # PDB 4V75 EM; 12.00 A; BS=1-110 # PDB 4V76 EM; 17.00 A; BS=1-110 # PDB 4V77 EM; 17.00 A; BS=1-110 # PDB 4V78 EM; 20.00 A; BS=1-110 # PDB 4V79 EM; 15.00 A; BS=1-110 # PDB 4V7A EM; 9.00 A; BS=1-110 # PDB 4V7B EM; 6.80 A; BS=1-110 # PDB 4V7C EM; 7.60 A; BU=1-110 # PDB 4V7D EM; 7.60 A; AV=1-110 # PDB 4V7I EM; 9.60 A; AS=1-110 # PDB 4V7S X-ray; 3.25 A; BS/DS=1-110 # PDB 4V7T X-ray; 3.19 A; BS/DS=1-110 # PDB 4V7U X-ray; 3.10 A; BS/DS=1-110 # PDB 4V7V X-ray; 3.29 A; BS/DS=1-110 # PDB 4V85 X-ray; 3.20 A; W=1-110 # PDB 4V89 X-ray; 3.70 A; BW=1-110 # PDB 4V9C X-ray; 3.30 A; BS/DS=1-110 # PDB 4V9D X-ray; 3.00 A; CS/DS=1-110 # PDB 4V9O X-ray; 2.90 A; AS/CS/ES/GS=1-110 # PDB 4V9P X-ray; 2.90 A; AS/CS/ES/GS=1-110 # PDB 4WF1 X-ray; 3.09 A; BS/DS=1-110 # PDB 4WOI X-ray; 3.00 A; BS/CS=1-110 # PDB 4WWW X-ray; 3.10 A; RS/YS=1-110 # PDB 4YBB X-ray; 2.10 A; CT/DT=1-110 # PDB 5ADY EM; 4.50 A; S=1-110 # PDB 5AFI EM; 2.90 A; S=1-110 # PDB 5AKA EM; 5.70 A; S=1-110 # PDB 5GAD EM; 3.70 A; T=1-110 # PDB 5GAE EM; 3.33 A; T=1-110 # PDB 5GAF EM; 4.30 A; T=1-110 # PDB 5GAG EM; 3.80 A; T=1-110 # PDB 5GAH EM; 3.80 A; T=1-110 # PDB 5IQR EM; 3.00 A; S=1-110 # PDB 5IT8 X-ray; 3.12 A; CT/DT=1-110 # PDB 5J5B X-ray; 2.80 A; CT/DT=1-110 # PDB 5J7L X-ray; 3.00 A; CT/DT=1-110 # PDB 5J88 X-ray; 3.32 A; CT/DT=1-110 # PDB 5J8A X-ray; 3.10 A; CT/DT=1-110 # PDB 5J91 X-ray; 2.96 A; CT/DT=1-110 # PDB 5JC9 X-ray; 3.03 A; CT/DT=1-110 # PDB 5JTE EM; 3.60 A; BS=1-110 # PDB 5JU8 EM; 3.60 A; BS=1-110 # PDB 5KCR EM; 3.60 A; 1W=1-110 # PDB 5KCS EM; 3.90 A; 1W=1-110 # PDB 5KPS EM; 3.90 A; S=1-110 # PDB 5KPV EM; 4.10 A; R=1-110 # PDB 5KPW EM; 3.90 A; R=1-110 # PDB 5KPX EM; 3.90 A; R=1-110 # PDB 5L3P EM; 3.70 A; W=1-110 # PIR G23129 R5EC22 # PROSITE PS00464 RIBOSOMAL_L22 # Pfam PF00237 Ribosomal_L22 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RL22_ECOLI 50S ribosomal protein L22 # RefSeq NP_417774 NC_000913.3 # RefSeq WP_000447529 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein L22P family. {ECO 0000305}. # SUBUNIT RL22_ECOLI Part of the 50S ribosomal subunit. # SUPFAM SSF54843 SSF54843 # TIGRFAMs TIGR01044 rplV_bact # eggNOG COG0091 LUCA BLAST swissprot:RL22_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RL22_ECOLI BioCyc ECOL316407:JW3277-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3277-MONOMER BioCyc EcoCyc:EG10882-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10882-MONOMER BioCyc MetaCyc:EG10882-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10882-MONOMER COG COG0091 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0091 DIP DIP-35983N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35983N DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1007/BF00295501 http://dx.doi.org/10.1007/BF00295501 DOI 10.1007/BF00333665 http://dx.doi.org/10.1007/BF00333665 DOI 10.1007/BF01429216 http://dx.doi.org/10.1007/BF01429216 DOI 10.1016/0014-5793(80)81276-2 http://dx.doi.org/10.1016/0014-5793(80)81276-2 DOI 10.1016/S0092-8674(02)00649-9 http://dx.doi.org/10.1016/S0092-8674(02)00649-9 DOI 10.1016/S0092-8674(03)00427-6 http://dx.doi.org/10.1016/S0092-8674(03)00427-6 DOI 10.1016/S1097-2765(01)00293-3 http://dx.doi.org/10.1016/S1097-2765(01)00293-3 DOI 10.1016/j.celrep.2014.09.011 http://dx.doi.org/10.1016/j.celrep.2014.09.011 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/13.12.4521 http://dx.doi.org/10.1093/nar/13.12.4521 DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1261/rna.5400703 http://dx.doi.org/10.1261/rna.5400703 DOI 10.1371/journal.pbio.1001866 http://dx.doi.org/10.1371/journal.pbio.1001866 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X02613 http://www.ebi.ac.uk/ena/data/view/X02613 EchoBASE EB0875 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0875 EcoGene EG10882 http://www.ecogene.org/geneInfo.php?eg_id=EG10882 EnsemblBacteria AAC76340 http://www.ensemblgenomes.org/id/AAC76340 EnsemblBacteria AAC76340 http://www.ensemblgenomes.org/id/AAC76340 EnsemblBacteria BAE77976 http://www.ensemblgenomes.org/id/BAE77976 EnsemblBacteria BAE77976 http://www.ensemblgenomes.org/id/BAE77976 EnsemblBacteria BAE77976 http://www.ensemblgenomes.org/id/BAE77976 EnsemblBacteria b3315 http://www.ensemblgenomes.org/id/b3315 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0022625 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022625 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.90.470.10 http://www.cathdb.info/version/latest/superfamily/3.90.470.10 GeneID 5548826 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5548826 GeneID 947813 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947813 HAMAP MF_01331_B http://hamap.expasy.org/unirule/MF_01331_B HOGENOM HOG000205046 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000205046&db=HOGENOM6 InParanoid P61175 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P61175 IntAct P61175 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P61175* InterPro IPR001063 http://www.ebi.ac.uk/interpro/entry/IPR001063 InterPro IPR005727 http://www.ebi.ac.uk/interpro/entry/IPR005727 InterPro IPR018260 http://www.ebi.ac.uk/interpro/entry/IPR018260 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW3277 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3277 KEGG_Gene eco:b3315 http://www.genome.jp/dbget-bin/www_bget?eco:b3315 KEGG_Orthology KO:K02890 http://www.genome.jp/dbget-bin/www_bget?KO:K02890 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 MINT MINT-1253134 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1253134 OMA VAILEHM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VAILEHM PANTHER PTHR13501 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13501 PDB 2J28 http://www.ebi.ac.uk/pdbe-srv/view/entry/2J28 PDB 2RDO http://www.ebi.ac.uk/pdbe-srv/view/entry/2RDO PDB 3BBX http://www.ebi.ac.uk/pdbe-srv/view/entry/3BBX PDB 3J5L http://www.ebi.ac.uk/pdbe-srv/view/entry/3J5L PDB 3J7Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J7Z PDB 3J8G http://www.ebi.ac.uk/pdbe-srv/view/entry/3J8G PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 4CSU http://www.ebi.ac.uk/pdbe-srv/view/entry/4CSU PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4UY8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4UY8 PDB 4V47 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V47 PDB 4V48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V48 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5ADY http://www.ebi.ac.uk/pdbe-srv/view/entry/5ADY PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5AKA http://www.ebi.ac.uk/pdbe-srv/view/entry/5AKA PDB 5GAD http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAD PDB 5GAE http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAE PDB 5GAF http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAF PDB 5GAG http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAG PDB 5GAH http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAH PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 2J28 http://www.ebi.ac.uk/pdbsum/2J28 PDBsum 2RDO http://www.ebi.ac.uk/pdbsum/2RDO PDBsum 3BBX http://www.ebi.ac.uk/pdbsum/3BBX PDBsum 3J5L http://www.ebi.ac.uk/pdbsum/3J5L PDBsum 3J7Z http://www.ebi.ac.uk/pdbsum/3J7Z PDBsum 3J8G http://www.ebi.ac.uk/pdbsum/3J8G PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 4CSU http://www.ebi.ac.uk/pdbsum/4CSU PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4UY8 http://www.ebi.ac.uk/pdbsum/4UY8 PDBsum 4V47 http://www.ebi.ac.uk/pdbsum/4V47 PDBsum 4V48 http://www.ebi.ac.uk/pdbsum/4V48 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5ADY http://www.ebi.ac.uk/pdbsum/5ADY PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5AKA http://www.ebi.ac.uk/pdbsum/5AKA PDBsum 5GAD http://www.ebi.ac.uk/pdbsum/5GAD PDBsum 5GAE http://www.ebi.ac.uk/pdbsum/5GAE PDBsum 5GAF http://www.ebi.ac.uk/pdbsum/5GAF PDBsum 5GAG http://www.ebi.ac.uk/pdbsum/5GAG PDBsum 5GAH http://www.ebi.ac.uk/pdbsum/5GAH PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PROSITE PS00464 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00464 PSORT swissprot:RL22_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RL22_ECOLI PSORT-B swissprot:RL22_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RL22_ECOLI PSORT2 swissprot:RL22_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RL22_ECOLI Pfam PF00237 http://pfam.xfam.org/family/PF00237 Phobius swissprot:RL22_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RL22_ECOLI PhylomeDB P61175 http://phylomedb.org/?seqid=P61175 ProteinModelPortal P61175 http://www.proteinmodelportal.org/query/uniprot/P61175 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 11511371 http://www.ncbi.nlm.nih.gov/pubmed/11511371 PubMed 11893334 http://www.ncbi.nlm.nih.gov/pubmed/11893334 PubMed 12809609 http://www.ncbi.nlm.nih.gov/pubmed/12809609 PubMed 13130133 http://www.ncbi.nlm.nih.gov/pubmed/13130133 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 24844575 http://www.ncbi.nlm.nih.gov/pubmed/24844575 PubMed 25310980 http://www.ncbi.nlm.nih.gov/pubmed/25310980 PubMed 3892488 http://www.ncbi.nlm.nih.gov/pubmed/3892488 PubMed 4589347 http://www.ncbi.nlm.nih.gov/pubmed/4589347 PubMed 7007072 http://www.ncbi.nlm.nih.gov/pubmed/7007072 PubMed 7729693 http://www.ncbi.nlm.nih.gov/pubmed/7729693 PubMed 7766155 http://www.ncbi.nlm.nih.gov/pubmed/7766155 PubMed 7928988 http://www.ncbi.nlm.nih.gov/pubmed/7928988 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417774 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417774 RefSeq WP_000447529 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000447529 SMR P61175 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P61175 STRING 511145.b3315 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3315&targetmode=cogs STRING COG0091 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0091&targetmode=cogs SUPFAM SSF54843 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54843 TIGRFAMs TIGR01044 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01044 UniProtKB RL22_ECOLI http://www.uniprot.org/uniprot/RL22_ECOLI UniProtKB-AC P61175 http://www.uniprot.org/uniprot/P61175 charge swissprot:RL22_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RL22_ECOLI eggNOG COG0091 http://eggnogapi.embl.de/nog_data/html/tree/COG0091 epestfind swissprot:RL22_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RL22_ECOLI garnier swissprot:RL22_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RL22_ECOLI helixturnhelix swissprot:RL22_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RL22_ECOLI hmoment swissprot:RL22_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RL22_ECOLI iep swissprot:RL22_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RL22_ECOLI inforesidue swissprot:RL22_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RL22_ECOLI octanol swissprot:RL22_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RL22_ECOLI pepcoil swissprot:RL22_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RL22_ECOLI pepdigest swissprot:RL22_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RL22_ECOLI pepinfo swissprot:RL22_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RL22_ECOLI pepnet swissprot:RL22_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RL22_ECOLI pepstats swissprot:RL22_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RL22_ECOLI pepwheel swissprot:RL22_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RL22_ECOLI pepwindow swissprot:RL22_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RL22_ECOLI sigcleave swissprot:RL22_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RL22_ECOLI ## Database ID URL or Descriptions # BioGrid 4260958 10 # CAUTION YIHY_ECOLI Was originally (PubMed 8955422) thought to be the tRNA- processing ribonuclease BN (rbn). This was later proven not to be the case (PubMed 15764599). {ECO 0000305|PubMed 15764599, ECO 0000305|PubMed 8955422}. # EcoGene EG11851 yihY # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # HAMAP MF_00672 UPF0761 # InterPro IPR017039 Virul_fac_BrkB # InterPro IPR023679 UPF0761_bac # Organism YIHY_ECOLI Escherichia coli (strain K12) # PATRIC 32123275 VBIEscCol129921_3998 # PIR S40830 S40830 # PIRSF PIRSF035875 RNase_BN # Pfam PF03631 Virul_fac_BrkB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIHY_ECOLI UPF0761 membrane protein YihY # RefSeq NP_418322 NC_000913.3 # RefSeq WP_000920762 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0761 family. {ECO 0000305}. # SUBCELLULAR LOCATION YIHY_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # TCDB 9.B.126.2 the putative lipid iv exporter (yhjd) family # TIGRFAMs TIGR00765 yihY_not_rbn # eggNOG COG1295 LUCA # eggNOG ENOG4107S2Z Bacteria BLAST swissprot:YIHY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIHY_ECOLI BioCyc ECOL316407:JW3857-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3857-MONOMER BioCyc EcoCyc:EG11851-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11851-MONOMER COG COG1295 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1295 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.C500098200 http://dx.doi.org/10.1074/jbc.C500098200 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1797 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1797 EcoGene EG11851 http://www.ecogene.org/geneInfo.php?eg_id=EG11851 EnsemblBacteria AAD13448 http://www.ensemblgenomes.org/id/AAD13448 EnsemblBacteria AAD13448 http://www.ensemblgenomes.org/id/AAD13448 EnsemblBacteria BAE77423 http://www.ensemblgenomes.org/id/BAE77423 EnsemblBacteria BAE77423 http://www.ensemblgenomes.org/id/BAE77423 EnsemblBacteria BAE77423 http://www.ensemblgenomes.org/id/BAE77423 EnsemblBacteria b3886 http://www.ensemblgenomes.org/id/b3886 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 948379 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948379 HAMAP MF_00672 http://hamap.expasy.org/unirule/MF_00672 HOGENOM HOG000259417 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000259417&db=HOGENOM6 InterPro IPR017039 http://www.ebi.ac.uk/interpro/entry/IPR017039 InterPro IPR023679 http://www.ebi.ac.uk/interpro/entry/IPR023679 KEGG_Gene ecj:JW3857 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3857 KEGG_Gene eco:b3886 http://www.genome.jp/dbget-bin/www_bget?eco:b3886 KEGG_Orthology KO:K07058 http://www.genome.jp/dbget-bin/www_bget?KO:K07058 OMA NKPAKYT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NKPAKYT PSORT swissprot:YIHY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIHY_ECOLI PSORT-B swissprot:YIHY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIHY_ECOLI PSORT2 swissprot:YIHY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIHY_ECOLI Pfam PF03631 http://pfam.xfam.org/family/PF03631 Phobius swissprot:YIHY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIHY_ECOLI PhylomeDB P0A8K8 http://phylomedb.org/?seqid=P0A8K8 ProteinModelPortal P0A8K8 http://www.proteinmodelportal.org/query/uniprot/P0A8K8 PubMed 15764599 http://www.ncbi.nlm.nih.gov/pubmed/15764599 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 8955422 http://www.ncbi.nlm.nih.gov/pubmed/8955422 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418322 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418322 RefSeq WP_000920762 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000920762 STRING 511145.b3886 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3886&targetmode=cogs STRING COG1295 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1295&targetmode=cogs TCDB 9.B.126.2 http://www.tcdb.org/search/result.php?tc=9.B.126.2 TIGRFAMs TIGR00765 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00765 UniProtKB YIHY_ECOLI http://www.uniprot.org/uniprot/YIHY_ECOLI UniProtKB-AC P0A8K8 http://www.uniprot.org/uniprot/P0A8K8 charge swissprot:YIHY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIHY_ECOLI eggNOG COG1295 http://eggnogapi.embl.de/nog_data/html/tree/COG1295 eggNOG ENOG4107S2Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107S2Z epestfind swissprot:YIHY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIHY_ECOLI garnier swissprot:YIHY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIHY_ECOLI helixturnhelix swissprot:YIHY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIHY_ECOLI hmoment swissprot:YIHY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIHY_ECOLI iep swissprot:YIHY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIHY_ECOLI inforesidue swissprot:YIHY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIHY_ECOLI octanol swissprot:YIHY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIHY_ECOLI pepcoil swissprot:YIHY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIHY_ECOLI pepdigest swissprot:YIHY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIHY_ECOLI pepinfo swissprot:YIHY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIHY_ECOLI pepnet swissprot:YIHY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIHY_ECOLI pepstats swissprot:YIHY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIHY_ECOLI pepwheel swissprot:YIHY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIHY_ECOLI pepwindow swissprot:YIHY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIHY_ECOLI sigcleave swissprot:YIHY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIHY_ECOLI ## Database ID URL or Descriptions # AltName VXIS_ECOLI Excisionase-like protein from lambdoid prophage 14 # BioGrid 4261343 4 # EcoGene EG14245 ymfG # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006310 DNA recombination; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # Gene3D 1.10.1660.20 -; 1. # IntAct P75970 25 # InterPro IPR009061 DNA-bd_dom_put # InterPro IPR012884 Excisionase-like # Organism VXIS_ECOLI Escherichia coli (strain K12) # PIR B64859 B64859 # Pfam PF07825 Exc # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Prophage excisionase-like protein {ECO 0000305} # RefSeq NP_415659 NC_000913.3 # RefSeq WP_000939945 NZ_CP010439.1 # SIMILARITY To lambdoid phages excisionases. {ECO 0000305}. # SUPFAM SSF46955 SSF46955 # eggNOG ENOG4105QYW Bacteria # eggNOG ENOG4111ZDC LUCA BLAST swissprot:VXIS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:VXIS_ECOLI BioCyc ECOL316407:JW1127-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1127-MONOMER BioCyc EcoCyc:G6585-MONOMER http://biocyc.org/getid?id=EcoCyc:G6585-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3995 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3995 EcoGene EG14245 http://www.ecogene.org/geneInfo.php?eg_id=EG14245 EnsemblBacteria AAC74225 http://www.ensemblgenomes.org/id/AAC74225 EnsemblBacteria AAC74225 http://www.ensemblgenomes.org/id/AAC74225 EnsemblBacteria BAA35970 http://www.ensemblgenomes.org/id/BAA35970 EnsemblBacteria BAA35970 http://www.ensemblgenomes.org/id/BAA35970 EnsemblBacteria BAA35970 http://www.ensemblgenomes.org/id/BAA35970 EnsemblBacteria b1141 http://www.ensemblgenomes.org/id/b1141 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 Gene3D 1.10.1660.20 http://www.cathdb.info/version/latest/superfamily/1.10.1660.20 GeneID 945705 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945705 HOGENOM HOG000267948 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267948&db=HOGENOM6 IntAct P75970 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75970* InterPro IPR009061 http://www.ebi.ac.uk/interpro/entry/IPR009061 InterPro IPR012884 http://www.ebi.ac.uk/interpro/entry/IPR012884 KEGG_Gene ecj:JW1127 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1127 KEGG_Gene eco:b1141 http://www.genome.jp/dbget-bin/www_bget?eco:b1141 OMA WALEEFS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WALEEFS PSORT swissprot:VXIS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:VXIS_ECOLI PSORT-B swissprot:VXIS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:VXIS_ECOLI PSORT2 swissprot:VXIS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:VXIS_ECOLI Pfam PF07825 http://pfam.xfam.org/family/PF07825 Phobius swissprot:VXIS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:VXIS_ECOLI ProteinModelPortal P75970 http://www.proteinmodelportal.org/query/uniprot/P75970 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415659 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415659 RefSeq WP_000939945 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000939945 SMR P75970 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75970 STRING 511145.b1141 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1141&targetmode=cogs SUPFAM SSF46955 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46955 UniProtKB VXIS_ECOLI http://www.uniprot.org/uniprot/VXIS_ECOLI UniProtKB-AC P75970 http://www.uniprot.org/uniprot/P75970 charge swissprot:VXIS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:VXIS_ECOLI eggNOG ENOG4105QYW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105QYW eggNOG ENOG4111ZDC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111ZDC epestfind swissprot:VXIS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:VXIS_ECOLI garnier swissprot:VXIS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:VXIS_ECOLI helixturnhelix swissprot:VXIS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:VXIS_ECOLI hmoment swissprot:VXIS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:VXIS_ECOLI iep swissprot:VXIS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:VXIS_ECOLI inforesidue swissprot:VXIS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:VXIS_ECOLI octanol swissprot:VXIS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:VXIS_ECOLI pepcoil swissprot:VXIS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:VXIS_ECOLI pepdigest swissprot:VXIS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:VXIS_ECOLI pepinfo swissprot:VXIS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:VXIS_ECOLI pepnet swissprot:VXIS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:VXIS_ECOLI pepstats swissprot:VXIS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:VXIS_ECOLI pepwheel swissprot:VXIS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:VXIS_ECOLI pepwindow swissprot:VXIS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:VXIS_ECOLI sigcleave swissprot:VXIS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:VXIS_ECOLI ## Database ID URL or Descriptions # BRENDA 4.1.1.19 2026 # BioGrid 4263079 10 # CATALYTIC ACTIVITY ADIA_ECOLI L-arginine = agmatine + CO(2). # CDD cd00615 Orn_deC_like # COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI 597326; # EcoGene EG11501 adiA # FUNCTION ADIA_ECOLI ADC can be found in two forms biodegradative and biosynthetic. The biodegradative form may play a role in regulating pH by consuming proteins. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0008792 arginine decarboxylase activity; IDA:EcoliWiki. # GO_function GO:0030170 pyridoxal phosphate binding; IDA:EcoCyc. # GO_process GO:0006527 arginine catabolic process; IDA:EcoliWiki. # GO_process GO:0051454 intracellular pH elevation; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0042592 homeostatic process # Gene3D 3.40.640.10 -; 1. # Gene3D 3.90.100.10 -; 1. # Gene3D 3.90.1150.10 -; 1. # INDUCTION ADIA_ECOLI Under conditions of acidic pH, anaerobiosis and rich medium. # IntAct P28629 6 # InterPro IPR000310 Orn/Lys/Arg_deCO2ase_major_dom # InterPro IPR005308 OKR_de-COase_N # InterPro IPR008286 Prn/Lys/Arg_de-COase_C # InterPro IPR011193 Orn/lys/arg_de-COase # InterPro IPR015421 PyrdxlP-dep_Trfase_major_sub1 # InterPro IPR015422 PyrdxlP-dep_Trfase_major_sub2 # InterPro IPR015424 PyrdxlP-dep_Trfase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00330 Arginine and proline metabolism # Organism ADIA_ECOLI Escherichia coli (strain K12) # PATRIC 32123799 VBIEscCol129921_4248 # PDB 2VYC X-ray; 2.40 A; A/B/C/D/E/F/G/H/I/J=1-755 # PIR S56346 S56346 # PIRSF PIRSF009393 Orn_decarb # PROSITE PS00703 OKR_DC_1 # Pfam PF01276 OKR_DC_1 # Pfam PF03709 OKR_DC_1_N # Pfam PF03711 OKR_DC_1_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ADIA_ECOLI Biodegradative arginine decarboxylase # RefSeq NP_418541 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA97017.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAE78119.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the Orn/Lys/Arg decarboxylase class-I family. {ECO 0000305}. # SUBCELLULAR LOCATION ADIA_ECOLI Cytoplasm. # SUBUNIT ADIA_ECOLI Homodecamer. # SUPFAM SSF53383 SSF53383 # SUPFAM SSF55904 SSF55904 # eggNOG COG1982 LUCA # eggNOG ENOG4105CXN Bacteria BLAST swissprot:ADIA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ADIA_ECOLI BioCyc ECOL316407:JW5731-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5731-MONOMER BioCyc EcoCyc:ARGDECARBOXDEG-MONOMER http://biocyc.org/getid?id=EcoCyc:ARGDECARBOXDEG-MONOMER BioCyc MetaCyc:ARGDECARBOXDEG-MONOMER http://biocyc.org/getid?id=MetaCyc:ARGDECARBOXDEG-MONOMER COG COG1982 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1982 DIP DIP-2903N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-2903N DOI 10.1016/0378-1119(87)90333-7 http://dx.doi.org/10.1016/0378-1119(87)90333-7 DOI 10.1021/bi00701a006 http://dx.doi.org/10.1021/bi00701a006 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.1.1.19 http://www.genome.jp/dbget-bin/www_bget?EC:4.1.1.19 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M18425 http://www.ebi.ac.uk/ena/data/view/M18425 EMBL M93362 http://www.ebi.ac.uk/ena/data/view/M93362 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 4.1.1.19 http://enzyme.expasy.org/EC/4.1.1.19 EchoBASE EB1464 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1464 EcoGene EG11501 http://www.ecogene.org/geneInfo.php?eg_id=EG11501 EnsemblBacteria AAC77078 http://www.ensemblgenomes.org/id/AAC77078 EnsemblBacteria AAC77078 http://www.ensemblgenomes.org/id/AAC77078 EnsemblBacteria BAE78119 http://www.ensemblgenomes.org/id/BAE78119 EnsemblBacteria BAE78119 http://www.ensemblgenomes.org/id/BAE78119 EnsemblBacteria BAE78119 http://www.ensemblgenomes.org/id/BAE78119 EnsemblBacteria b4117 http://www.ensemblgenomes.org/id/b4117 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008792 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008792 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_process GO:0006527 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006527 GO_process GO:0051454 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051454 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 Gene3D 3.40.640.10 http://www.cathdb.info/version/latest/superfamily/3.40.640.10 Gene3D 3.90.100.10 http://www.cathdb.info/version/latest/superfamily/3.90.100.10 Gene3D 3.90.1150.10 http://www.cathdb.info/version/latest/superfamily/3.90.1150.10 GeneID 948638 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948638 HOGENOM HOG000164394 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000164394&db=HOGENOM6 InParanoid P28629 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P28629 IntAct P28629 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P28629* IntEnz 4.1.1.19 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.1.19 InterPro IPR000310 http://www.ebi.ac.uk/interpro/entry/IPR000310 InterPro IPR005308 http://www.ebi.ac.uk/interpro/entry/IPR005308 InterPro IPR008286 http://www.ebi.ac.uk/interpro/entry/IPR008286 InterPro IPR011193 http://www.ebi.ac.uk/interpro/entry/IPR011193 InterPro IPR015421 http://www.ebi.ac.uk/interpro/entry/IPR015421 InterPro IPR015422 http://www.ebi.ac.uk/interpro/entry/IPR015422 InterPro IPR015424 http://www.ebi.ac.uk/interpro/entry/IPR015424 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5731 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5731 KEGG_Gene eco:b4117 http://www.genome.jp/dbget-bin/www_bget?eco:b4117 KEGG_Orthology KO:K01584 http://www.genome.jp/dbget-bin/www_bget?KO:K01584 KEGG_Pathway ko00330 http://www.genome.jp/kegg-bin/show_pathway?ko00330 KEGG_Reaction rn:R00566 http://www.genome.jp/dbget-bin/www_bget?rn:R00566 MINT MINT-1241522 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1241522 OMA PSCWVLK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PSCWVLK PDB 2VYC http://www.ebi.ac.uk/pdbe-srv/view/entry/2VYC PDBsum 2VYC http://www.ebi.ac.uk/pdbsum/2VYC PROSITE PS00703 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00703 PSORT swissprot:ADIA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ADIA_ECOLI PSORT-B swissprot:ADIA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ADIA_ECOLI PSORT2 swissprot:ADIA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ADIA_ECOLI Pfam PF01276 http://pfam.xfam.org/family/PF01276 Pfam PF03709 http://pfam.xfam.org/family/PF03709 Pfam PF03711 http://pfam.xfam.org/family/PF03711 Phobius swissprot:ADIA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ADIA_ECOLI PhylomeDB P28629 http://phylomedb.org/?seqid=P28629 ProteinModelPortal P28629 http://www.proteinmodelportal.org/query/uniprot/P28629 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2830169 http://www.ncbi.nlm.nih.gov/pubmed/2830169 PubMed 4204273 http://www.ncbi.nlm.nih.gov/pubmed/4204273 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8383109 http://www.ncbi.nlm.nih.gov/pubmed/8383109 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418541 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418541 SMR P28629 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P28629 STRING 511145.b4117 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4117&targetmode=cogs STRING COG1982 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1982&targetmode=cogs SUPFAM SSF53383 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53383 SUPFAM SSF55904 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55904 UniProtKB ADIA_ECOLI http://www.uniprot.org/uniprot/ADIA_ECOLI UniProtKB-AC P28629 http://www.uniprot.org/uniprot/P28629 charge swissprot:ADIA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ADIA_ECOLI eggNOG COG1982 http://eggnogapi.embl.de/nog_data/html/tree/COG1982 eggNOG ENOG4105CXN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CXN epestfind swissprot:ADIA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ADIA_ECOLI garnier swissprot:ADIA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ADIA_ECOLI helixturnhelix swissprot:ADIA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ADIA_ECOLI hmoment swissprot:ADIA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ADIA_ECOLI iep swissprot:ADIA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ADIA_ECOLI inforesidue swissprot:ADIA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ADIA_ECOLI octanol swissprot:ADIA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ADIA_ECOLI pepcoil swissprot:ADIA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ADIA_ECOLI pepdigest swissprot:ADIA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ADIA_ECOLI pepinfo swissprot:ADIA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ADIA_ECOLI pepnet swissprot:ADIA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ADIA_ECOLI pepstats swissprot:ADIA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ADIA_ECOLI pepwheel swissprot:ADIA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ADIA_ECOLI pepwindow swissprot:ADIA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ADIA_ECOLI sigcleave swissprot:ADIA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ADIA_ECOLI ## Database ID URL or Descriptions # AltName Glutamate succinic semialdehyde transaminase # AltName PUUE_ECOLI GABA aminotransferase # AltName PUUE_ECOLI Gamma-amino-N-butyrate transaminase # BIOPHYSICOCHEMICAL PROPERTIES PUUE_ECOLI Kinetic parameters KM=0.0577 mM for SSA (at pH 7.8 and at 30 degrees Celsius) {ECO 0000269|PubMed 20639325}; KM=1.57 mM for GABA (at pH 7.8 and at 30 degrees Celsius) {ECO 0000269|PubMed 20639325}; KM=5.1 mM for KG (at pH 7.8 and at 30 degrees Celsius) {ECO 0000269|PubMed 20639325}; KM=18 mM for L-glutamate (at pH 7.8 and at 30 degrees Celsius) {ECO 0000269|PubMed 20639325}; pH dependence Optimum pH is 9 for the forward reaction which is the transfer reaction of the amino group from GABA to beta-ketoglutarate, and pH 8 for the reverse reaction. {ECO 0000269|PubMed 20639325}; # BioGrid 4263526 16 # CATALYTIC ACTIVITY PUUE_ECOLI 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate. # CDD cd00610 OAT_like # COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI 597326; # DISRUPTION PHENOTYPE Cells show only 35% of the wild-type activity. {ECO:0000269|PubMed 20639325}. # ENZYME REGULATION Completely inhibited by succinate and low- aeration conditions. {ECO:0000269|PubMed 20639325}. # EcoGene EG13187 puuE # FUNCTION PUUE_ECOLI Catalyzes the transfer of the amino group from gamma- aminobutyrate (GABA) to alpha-ketoglutarate (KG) to yield succinic semialdehyde (SSA). PuuE is important for utilization of putrescine as the sole nitrogen or carbon source. {ECO 0000269|PubMed 15590624, ECO 0000269|PubMed 20639325}. # GO_function GO:0003867 4-aminobutyrate transaminase activity; IDA:EcoCyc. # GO_function GO:0030170 pyridoxal phosphate binding; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IBA:GO_Central. # GO_process GO:0009447 putrescine catabolic process; IMP:EcoCyc. # GO_process GO:0009448 gamma-aminobutyric acid metabolic process; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.640.10 -; 1. # Gene3D 3.90.1150.10 -; 1. # INDUCTION By putrescine. {ECO:0000269|PubMed 20639325}. # IntAct P50457 3 # InterPro IPR004632 4NH2But_aminotransferase_bac # InterPro IPR005814 Aminotrans_3 # InterPro IPR015421 PyrdxlP-dep_Trfase_major_sub1 # InterPro IPR015422 PyrdxlP-dep_Trfase_major_sub2 # InterPro IPR015424 PyrdxlP-dep_Trfase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01007 Amino acid related enzymes # KEGG_Pathway ko00250 Alanine, aspartate and glutamate metabolism # KEGG_Pathway ko00410 beta-Alanine metabolism # KEGG_Pathway ko00640 Propanoate metabolism # KEGG_Pathway ko00650 Butanoate metabolism # Organism PUUE_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11986 PTHR11986 # PATHWAY Amine and polyamine degradation; putrescine degradation; succinate semialdehyde from 4-aminobutanoate step 1/1. # PATRIC 32117876 VBIEscCol129921_1358 # PIR A64879 A64879 # PROSITE PS00600 AA_TRANSFER_CLASS_3 # Pfam PF00202 Aminotran_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PUUE_ECOLI 4-aminobutyrate aminotransferase PuuE # RefSeq NP_415818 NC_000913.3 # RefSeq WP_000069229 NZ_LN832404.1 # SIMILARITY Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. {ECO 0000305}. # SUPFAM SSF53383 SSF53383 # TIGRFAMs TIGR00700 GABAtrnsam # UniPathway UPA00188 UER00293 # eggNOG COG0160 LUCA # eggNOG ENOG4108JPW Bacteria BLAST swissprot:PUUE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PUUE_ECOLI BioCyc ECOL316407:JW1295-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1295-MONOMER BioCyc EcoCyc:G6646-MONOMER http://biocyc.org/getid?id=EcoCyc:G6646-MONOMER BioCyc MetaCyc:G6646-MONOMER http://biocyc.org/getid?id=MetaCyc:G6646-MONOMER COG COG0160 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0160 DIP DIP-9825N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9825N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M411114200 http://dx.doi.org/10.1074/jbc.M411114200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00308-10 http://dx.doi.org/10.1128/JB.00308-10 EC_number EC:2.6.1.19 http://www.genome.jp/dbget-bin/www_bget?EC:2.6.1.19 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U38543 http://www.ebi.ac.uk/ena/data/view/U38543 ENZYME 2.6.1.19 http://enzyme.expasy.org/EC/2.6.1.19 EchoBASE EB2979 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2979 EcoGene EG13187 http://www.ecogene.org/geneInfo.php?eg_id=EG13187 EnsemblBacteria AAC74384 http://www.ensemblgenomes.org/id/AAC74384 EnsemblBacteria AAC74384 http://www.ensemblgenomes.org/id/AAC74384 EnsemblBacteria BAA14871 http://www.ensemblgenomes.org/id/BAA14871 EnsemblBacteria BAA14871 http://www.ensemblgenomes.org/id/BAA14871 EnsemblBacteria BAA14871 http://www.ensemblgenomes.org/id/BAA14871 EnsemblBacteria b1302 http://www.ensemblgenomes.org/id/b1302 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003867 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003867 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0009447 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009447 GO_process GO:0009448 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009448 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.640.10 http://www.cathdb.info/version/latest/superfamily/3.40.640.10 Gene3D 3.90.1150.10 http://www.cathdb.info/version/latest/superfamily/3.90.1150.10 GeneID 945446 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945446 HOGENOM HOG000020206 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000020206&db=HOGENOM6 InParanoid P50457 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P50457 IntAct P50457 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P50457* IntEnz 2.6.1.19 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.6.1.19 InterPro IPR004632 http://www.ebi.ac.uk/interpro/entry/IPR004632 InterPro IPR005814 http://www.ebi.ac.uk/interpro/entry/IPR005814 InterPro IPR015421 http://www.ebi.ac.uk/interpro/entry/IPR015421 InterPro IPR015422 http://www.ebi.ac.uk/interpro/entry/IPR015422 InterPro IPR015424 http://www.ebi.ac.uk/interpro/entry/IPR015424 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Gene ecj:JW1295 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1295 KEGG_Gene eco:b1302 http://www.genome.jp/dbget-bin/www_bget?eco:b1302 KEGG_Orthology KO:K00823 http://www.genome.jp/dbget-bin/www_bget?KO:K00823 KEGG_Pathway ko00250 http://www.genome.jp/kegg-bin/show_pathway?ko00250 KEGG_Pathway ko00410 http://www.genome.jp/kegg-bin/show_pathway?ko00410 KEGG_Pathway ko00640 http://www.genome.jp/kegg-bin/show_pathway?ko00640 KEGG_Pathway ko00650 http://www.genome.jp/kegg-bin/show_pathway?ko00650 KEGG_Reaction rn:R00908 http://www.genome.jp/dbget-bin/www_bget?rn:R00908 KEGG_Reaction rn:R01648 http://www.genome.jp/dbget-bin/www_bget?rn:R01648 MINT MINT-1256713 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1256713 OMA CKVFFAS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CKVFFAS PANTHER PTHR11986 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11986 PROSITE PS00600 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00600 PSORT swissprot:PUUE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PUUE_ECOLI PSORT-B swissprot:PUUE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PUUE_ECOLI PSORT2 swissprot:PUUE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PUUE_ECOLI Pfam PF00202 http://pfam.xfam.org/family/PF00202 Phobius swissprot:PUUE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PUUE_ECOLI PhylomeDB P50457 http://phylomedb.org/?seqid=P50457 ProteinModelPortal P50457 http://www.proteinmodelportal.org/query/uniprot/P50457 PubMed 15590624 http://www.ncbi.nlm.nih.gov/pubmed/15590624 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20639325 http://www.ncbi.nlm.nih.gov/pubmed/20639325 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415818 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415818 RefSeq WP_000069229 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000069229 SMR P50457 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P50457 STRING 511145.b1302 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1302&targetmode=cogs STRING COG0160 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0160&targetmode=cogs SUPFAM SSF53383 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53383 TIGRFAMs TIGR00700 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00700 UniProtKB PUUE_ECOLI http://www.uniprot.org/uniprot/PUUE_ECOLI UniProtKB-AC P50457 http://www.uniprot.org/uniprot/P50457 charge swissprot:PUUE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PUUE_ECOLI eggNOG COG0160 http://eggnogapi.embl.de/nog_data/html/tree/COG0160 eggNOG ENOG4108JPW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108JPW epestfind swissprot:PUUE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PUUE_ECOLI garnier swissprot:PUUE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PUUE_ECOLI helixturnhelix swissprot:PUUE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PUUE_ECOLI hmoment swissprot:PUUE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PUUE_ECOLI iep swissprot:PUUE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PUUE_ECOLI inforesidue swissprot:PUUE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PUUE_ECOLI octanol swissprot:PUUE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PUUE_ECOLI pepcoil swissprot:PUUE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PUUE_ECOLI pepdigest swissprot:PUUE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PUUE_ECOLI pepinfo swissprot:PUUE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PUUE_ECOLI pepnet swissprot:PUUE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PUUE_ECOLI pepstats swissprot:PUUE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PUUE_ECOLI pepwheel swissprot:PUUE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PUUE_ECOLI pepwindow swissprot:PUUE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PUUE_ECOLI sigcleave swissprot:PUUE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PUUE_ECOLI ## Database ID URL or Descriptions # AltName ISCA_ECOLI Iron-sulfur cluster assembly protein # BioGrid 4260603 23 # COFACTOR Name=Fe cation; Xref=ChEBI:CHEBI 24875; Note=Binds 2 iron ions per dimer. The dimer may bind additional iron ions.; # EcoGene EG12132 iscA # FUNCTION ISCA_ECOLI Is able to transfer iron-sulfur clusters to apo- ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0005198 structural molecule activity; IEA:InterPro. # GO_function GO:0008198 ferrous iron binding; IDA:EcoCyc. # GO_function GO:0034986 iron chaperone activity; IDA:EcoCyc. # GO_function GO:0051537 2 iron, 2 sulfur cluster binding; IDA:UniProtKB. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IBA:GO_Central. # GO_process GO:0006790 sulfur compound metabolic process; IBA:GO_Central. # GO_process GO:0016226 iron-sulfur cluster assembly; IDA:UniProtKB. # GO_process GO:0097428 protein maturation by iron-sulfur cluster transfer; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0005198 structural molecule activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0051186 cofactor metabolic process # GOslim_process GO:0051604 protein maturation # Gene3D 2.60.300.12 -; 1. # HAMAP MF_01429 Fe_S_insert_IscA # INDUCTION ISCA_ECOLI Repressed by IscR. # INTERACTION ISCA_ECOLI P0A9R4 fdx; NbExp=4; IntAct=EBI-767026, EBI-767037; # IntAct P0AAC8 5 # InterPro IPR000361 FeS_biogenesis # InterPro IPR011302 IscA_proteobacteria # InterPro IPR016092 FeS_cluster_insertion # InterPro IPR017870 FeS_cluster_insertion_CS # InterPro IPR031108 ISCA-like # KEGG_Brite ko03016 Transfer RNA biogenesis # MISCELLANEOUS ISCA_ECOLI 2 iron atoms may bind between dimers. # Organism ISCA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10072:SF48 PTHR10072:SF48 # PATRIC 32120453 VBIEscCol129921_2629 # PDB 1R94 X-ray; 2.30 A; A/B=1-105 # PDB 1R95 X-ray; 2.65 A; A/B=1-105 # PDB 1S98 X-ray; 2.30 A; A/B=1-107 # PIR G65029 G65029 # PROSITE PS01152 HESB # Pfam PF01521 Fe-S_biosyn # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ISCA_ECOLI Iron-binding protein IscA # RefSeq NP_417023 NC_000913.3 # RefSeq WP_000028953 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=U01827; Type=Frameshift; Positions=Several; Evidence={ECO 0000305}; # SIMILARITY Belongs to the HesB/IscA family. {ECO 0000305}. # SUBUNIT ISCA_ECOLI Homodimer; may form tetramers and higher multimers. {ECO 0000269|PubMed 14705938, ECO 0000269|PubMed 15050828}. # SUPFAM SSF89360 SSF89360 # TIGRFAMs TIGR00049 TIGR00049 # TIGRFAMs TIGR02011 IscA # eggNOG COG0316 LUCA # eggNOG ENOG4108Z4V Bacteria BLAST swissprot:ISCA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ISCA_ECOLI BioCyc ECOL316407:JW2512-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2512-MONOMER BioCyc EcoCyc:EG12132-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12132-MONOMER BioCyc MetaCyc:EG12132-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12132-MONOMER COG COG0316 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0316 DIP DIP-35854N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35854N DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1016/j.jmb.2004.02.027 http://dx.doi.org/10.1016/j.jmb.2004.02.027 DOI 10.1021/bi035440s http://dx.doi.org/10.1021/bi035440s DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/BJ20031702 http://dx.doi.org/10.1042/BJ20031702 DOI 10.1074/jbc.M102902200 http://dx.doi.org/10.1074/jbc.M102902200 DOI 10.1074/jbc.M404533200 http://dx.doi.org/10.1074/jbc.M404533200 DOI 10.1074/jbc.M504344200 http://dx.doi.org/10.1074/jbc.M504344200 DOI 10.1074/jbc.M504638200 http://dx.doi.org/10.1074/jbc.M504638200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U01827 http://www.ebi.ac.uk/ena/data/view/U01827 EchoBASE EB2053 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2053 EcoGene EG12132 http://www.ecogene.org/geneInfo.php?eg_id=EG12132 EnsemblBacteria AAC75581 http://www.ensemblgenomes.org/id/AAC75581 EnsemblBacteria AAC75581 http://www.ensemblgenomes.org/id/AAC75581 EnsemblBacteria BAA16422 http://www.ensemblgenomes.org/id/BAA16422 EnsemblBacteria BAA16422 http://www.ensemblgenomes.org/id/BAA16422 EnsemblBacteria BAA16422 http://www.ensemblgenomes.org/id/BAA16422 EnsemblBacteria b2528 http://www.ensemblgenomes.org/id/b2528 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0005198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005198 GO_function GO:0008198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008198 GO_function GO:0034986 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034986 GO_function GO:0051537 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051537 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GO_process GO:0016226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016226 GO_process GO:0097428 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097428 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0005198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005198 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GOslim_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 Gene3D 2.60.300.12 http://www.cathdb.info/version/latest/superfamily/2.60.300.12 GeneID 946999 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946999 HAMAP MF_01429 http://hamap.expasy.org/unirule/MF_01429 HOGENOM HOG000228314 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000228314&db=HOGENOM6 InParanoid P0AAC8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAC8 IntAct P0AAC8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAC8* InterPro IPR000361 http://www.ebi.ac.uk/interpro/entry/IPR000361 InterPro IPR011302 http://www.ebi.ac.uk/interpro/entry/IPR011302 InterPro IPR016092 http://www.ebi.ac.uk/interpro/entry/IPR016092 InterPro IPR017870 http://www.ebi.ac.uk/interpro/entry/IPR017870 InterPro IPR031108 http://www.ebi.ac.uk/interpro/entry/IPR031108 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW2512 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2512 KEGG_Gene eco:b2528 http://www.genome.jp/dbget-bin/www_bget?eco:b2528 KEGG_Orthology KO:K13628 http://www.genome.jp/dbget-bin/www_bget?KO:K13628 OMA EYTMEYV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EYTMEYV PANTHER PTHR10072:SF48 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10072:SF48 PDB 1R94 http://www.ebi.ac.uk/pdbe-srv/view/entry/1R94 PDB 1R95 http://www.ebi.ac.uk/pdbe-srv/view/entry/1R95 PDB 1S98 http://www.ebi.ac.uk/pdbe-srv/view/entry/1S98 PDBsum 1R94 http://www.ebi.ac.uk/pdbsum/1R94 PDBsum 1R95 http://www.ebi.ac.uk/pdbsum/1R95 PDBsum 1S98 http://www.ebi.ac.uk/pdbsum/1S98 PROSITE PS01152 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01152 PSORT swissprot:ISCA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ISCA_ECOLI PSORT-B swissprot:ISCA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ISCA_ECOLI PSORT2 swissprot:ISCA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ISCA_ECOLI Pfam PF01521 http://pfam.xfam.org/family/PF01521 Phobius swissprot:ISCA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ISCA_ECOLI PhylomeDB P0AAC8 http://phylomedb.org/?seqid=P0AAC8 ProteinModelPortal P0AAC8 http://www.proteinmodelportal.org/query/uniprot/P0AAC8 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 11319236 http://www.ncbi.nlm.nih.gov/pubmed/11319236 PubMed 14705938 http://www.ncbi.nlm.nih.gov/pubmed/14705938 PubMed 14720122 http://www.ncbi.nlm.nih.gov/pubmed/14720122 PubMed 15050828 http://www.ncbi.nlm.nih.gov/pubmed/15050828 PubMed 15247288 http://www.ncbi.nlm.nih.gov/pubmed/15247288 PubMed 15964837 http://www.ncbi.nlm.nih.gov/pubmed/15964837 PubMed 15985427 http://www.ncbi.nlm.nih.gov/pubmed/15985427 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8300516 http://www.ncbi.nlm.nih.gov/pubmed/8300516 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417023 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417023 RefSeq WP_000028953 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000028953 SMR P0AAC8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAC8 STRING 511145.b2528 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2528&targetmode=cogs STRING COG0316 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0316&targetmode=cogs SUPFAM SSF89360 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF89360 TIGRFAMs TIGR00049 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00049 TIGRFAMs TIGR02011 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02011 UniProtKB ISCA_ECOLI http://www.uniprot.org/uniprot/ISCA_ECOLI UniProtKB-AC P0AAC8 http://www.uniprot.org/uniprot/P0AAC8 charge swissprot:ISCA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ISCA_ECOLI eggNOG COG0316 http://eggnogapi.embl.de/nog_data/html/tree/COG0316 eggNOG ENOG4108Z4V http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Z4V epestfind swissprot:ISCA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ISCA_ECOLI garnier swissprot:ISCA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ISCA_ECOLI helixturnhelix swissprot:ISCA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ISCA_ECOLI hmoment swissprot:ISCA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ISCA_ECOLI iep swissprot:ISCA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ISCA_ECOLI inforesidue swissprot:ISCA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ISCA_ECOLI octanol swissprot:ISCA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ISCA_ECOLI pepcoil swissprot:ISCA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ISCA_ECOLI pepdigest swissprot:ISCA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ISCA_ECOLI pepinfo swissprot:ISCA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ISCA_ECOLI pepnet swissprot:ISCA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ISCA_ECOLI pepstats swissprot:ISCA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ISCA_ECOLI pepwheel swissprot:ISCA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ISCA_ECOLI pepwindow swissprot:ISCA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ISCA_ECOLI sigcleave swissprot:ISCA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ISCA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259376 606 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG12560 yjhR # GO_function GO:0016787 hydrolase activity; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # IntAct P39369 7 # InterPro IPR001736 PLipase_D/transphosphatidylase # InterPro IPR025202 PLD-like_dom # InterPro IPR027417 P-loop_NTPase # Organism YJHR_ECOLI Escherichia coli (strain K12) # PATRIC 48668203 VBIEscCol107702_4352 # PIR S56533 S56533 # PROSITE PS50035 PLD # Pfam PF13091 PLDc_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJHR_ECOLI Putative uncharacterized protein YjhR # RefSeq WP_001312504 NZ_LN832404.1 # SIMILARITY Contains 1 PLD phosphodiesterase domain. {ECO:0000255|PROSITE-ProRule PRU00153}. # SUPFAM SSF52540 SSF52540 # eggNOG COG1112 LUCA BLAST swissprot:YJHR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJHR_ECOLI BioCyc ECOL316407:JW4271-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4271-MONOMER BioCyc EcoCyc:G7918-MONOMER http://biocyc.org/getid?id=EcoCyc:G7918-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2448 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2448 EcoGene EG12560 http://www.ecogene.org/geneInfo.php?eg_id=EG12560 EnsemblBacteria BAE78301 http://www.ensemblgenomes.org/id/BAE78301 EnsemblBacteria BAE78301 http://www.ensemblgenomes.org/id/BAE78301 EnsemblBacteria BAE78301 http://www.ensemblgenomes.org/id/BAE78301 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016787 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016787 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 HOGENOM HOG000081394 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000081394&db=HOGENOM6 IntAct P39369 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39369* InterPro IPR001736 http://www.ebi.ac.uk/interpro/entry/IPR001736 InterPro IPR025202 http://www.ebi.ac.uk/interpro/entry/IPR025202 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Gene ecj:JW4271 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4271 OMA EHHESLQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EHHESLQ PROSITE PS50035 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50035 PSORT swissprot:YJHR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJHR_ECOLI PSORT-B swissprot:YJHR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJHR_ECOLI PSORT2 swissprot:YJHR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJHR_ECOLI Pfam PF13091 http://pfam.xfam.org/family/PF13091 Phobius swissprot:YJHR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJHR_ECOLI ProteinModelPortal P39369 http://www.proteinmodelportal.org/query/uniprot/P39369 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001312504 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001312504 SMR P39369 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39369 STRING 316407.85677051 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85677051&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB YJHR_ECOLI http://www.uniprot.org/uniprot/YJHR_ECOLI UniProtKB-AC P39369 http://www.uniprot.org/uniprot/P39369 charge swissprot:YJHR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJHR_ECOLI eggNOG COG1112 http://eggnogapi.embl.de/nog_data/html/tree/COG1112 epestfind swissprot:YJHR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJHR_ECOLI garnier swissprot:YJHR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJHR_ECOLI helixturnhelix swissprot:YJHR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJHR_ECOLI hmoment swissprot:YJHR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJHR_ECOLI iep swissprot:YJHR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJHR_ECOLI inforesidue swissprot:YJHR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJHR_ECOLI octanol swissprot:YJHR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJHR_ECOLI pepcoil swissprot:YJHR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJHR_ECOLI pepdigest swissprot:YJHR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJHR_ECOLI pepinfo swissprot:YJHR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJHR_ECOLI pepnet swissprot:YJHR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJHR_ECOLI pepstats swissprot:YJHR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJHR_ECOLI pepwheel swissprot:YJHR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJHR_ECOLI pepwindow swissprot:YJHR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJHR_ECOLI sigcleave swissprot:YJHR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJHR_ECOLI ## Database ID URL or Descriptions # AltName TDH_ECOLI L-threonine dehydrogenase {ECO 0000303|PubMed 2647748, ECO 0000303|PubMed 6780553} # BIOPHYSICOCHEMICAL PROPERTIES TDH_ECOLI Kinetic parameters KM=1.43 mM for L-threonine (at 37 degrees Celsius and pH 8.4) {ECO 0000269|PubMed 6780553}; KM=0.19 mM for NAD(+) (at 37 degrees Celsius and pH 8.4) {ECO 0000269|PubMed 6780553}; Vmax=57 umol/min/mg enzyme for the NAD(+) oxidation of L- threonine {ECO 0000269|PubMed 6780553}; pH dependence Optimum pH is 10.3. At pH 9.0 and 11.0, the activity is 35% and only 6%, respectively, of the optimal level. {ECO 0000269|PubMed 6780553}; # BioGrid 4263307 21 # CATALYTIC ACTIVITY TDH_ECOLI L-threonine + NAD(+) = L-2-amino-3- oxobutanoate + NADH. {ECO 0000255|HAMAP-Rule MF_00627, ECO 0000269|PubMed 6780553}. # COFACTOR TDH_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000255|HAMAP-Rule MF_00627, ECO 0000269|PubMed 2007567, ECO 0000305|PubMed 9784233}; Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000269|PubMed 2007567}; Name=Cd(2+); Xref=ChEBI CHEBI 48775; Evidence={ECO 0000269|PubMed 2007567}; Note=Binds 2 Zn(2+) ions per subunit. Co(2+) and Cd(2+) can exchange for Zn(2+) (PubMed 2007567). Probably contains one structural ion and one catalytic ion that seems to be less tightly bound at the site (PubMed 9784233). {ECO 0000255|HAMAP- Rule MF_00627, ECO 0000269|PubMed 2007567, ECO 0000305|PubMed 9784233}; # ENZYME REGULATION Is totally inhibited by EDTA in vitro. {ECO:0000269|PubMed 2007567}. # EcoGene EG10993 tdh # FUNCTION TDH_ECOLI Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate. To a lesser extent, also catalyzes the oxidation of D-allo-threonine and L-threonine amide, but not that of D-threonine and L-allothreonine. Cannot utilize NADP(+) instead of NAD(+). {ECO 0000269|PubMed 6780553}. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0008198 ferrous iron binding; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IDA:EcoliWiki. # GO_function GO:0008743 L-threonine 3-dehydrogenase activity; IDA:EcoCyc. # GO_function GO:0016491 oxidoreductase activity; IDA:EcoliWiki. # GO_function GO:0030145 manganese ion binding; IDA:EcoliWiki. # GO_function GO:0046870 cadmium ion binding; IDA:EcoliWiki. # GO_process GO:0006564 L-serine biosynthetic process; IGI:EcoliWiki. # GO_process GO:0006567 threonine catabolic process; IMP:EcoCyc. # GO_process GO:0019518 L-threonine catabolic process to glycine; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.720 -; 1. # Gene3D 3.90.180.10 -; 1. # HAMAP MF_00627 Thr_dehydrog # IntAct P07913 6 # InterPro IPR002085 ADH_SF_Zn-type # InterPro IPR002328 ADH_Zn_CS # InterPro IPR004627 L-Threonine_3-DHase # InterPro IPR011032 GroES-like # InterPro IPR013149 ADH_C # InterPro IPR013154 ADH_N # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR020843 PKS_ER # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00260 Glycine, serine and threonine metabolism # Organism TDH_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11695 PTHR11695 # PATHWAY Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 1/2. {ECO 0000255|HAMAP-Rule:MF_00627}. # PATRIC 32122719 VBIEscCol129921_3736 # PIR A33276 DEECTH # PROSITE PS00059 ADH_ZINC # Pfam PF00107 ADH_zinc_N # Pfam PF08240 ADH_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName L-threonine 3-dehydrogenase {ECO:0000255|HAMAP-Rule MF_00627} # RefSeq NP_418073 NC_000913.3 # RefSeq WP_000646007 NZ_LN832404.1 # SIMILARITY Belongs to the zinc-containing alcohol dehydrogenase family. {ECO:0000255|HAMAP-Rule MF_00627}. # SMART SM00829 PKS_ER # SUBCELLULAR LOCATION TDH_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00627}. # SUBUNIT Homotetramer. {ECO:0000269|PubMed 6780553}. # SUPFAM SSF50129 SSF50129 # SUPFAM SSF51735 SSF51735 # TIGRFAMs TIGR00692 tdh # UniPathway UPA00046 UER00505 # eggNOG COG1063 LUCA # eggNOG ENOG4105CPQ Bacteria BLAST swissprot:TDH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TDH_ECOLI BioCyc ECOL316407:JW3591-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3591-MONOMER BioCyc EcoCyc:THREODEHYD-MONOMER http://biocyc.org/getid?id=EcoCyc:THREODEHYD-MONOMER BioCyc MetaCyc:THREODEHYD-MONOMER http://biocyc.org/getid?id=MetaCyc:THREODEHYD-MONOMER COG COG1063 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1063 DIP DIP-6855N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-6855N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/abbi.1998.0845 http://dx.doi.org/10.1006/abbi.1998.0845 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.103 {ECO:0000255|HAMAP-Rule:MF_00627, ECO:0000269|PubMed:6780553} http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.103 {ECO:0000255|HAMAP-Rule:MF_00627, ECO:0000269|PubMed:6780553} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X06690 http://www.ebi.ac.uk/ena/data/view/X06690 ENZYME 1.1.1.103 {ECO:0000255|HAMAP-Rule:MF_00627, ECO:0000269|PubMed:6780553} http://enzyme.expasy.org/EC/1.1.1.103 {ECO:0000255|HAMAP-Rule:MF_00627, ECO:0000269|PubMed:6780553} EchoBASE EB0986 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0986 EcoGene EG10993 http://www.ecogene.org/geneInfo.php?eg_id=EG10993 EnsemblBacteria AAC76640 http://www.ensemblgenomes.org/id/AAC76640 EnsemblBacteria AAC76640 http://www.ensemblgenomes.org/id/AAC76640 EnsemblBacteria BAE77676 http://www.ensemblgenomes.org/id/BAE77676 EnsemblBacteria BAE77676 http://www.ensemblgenomes.org/id/BAE77676 EnsemblBacteria BAE77676 http://www.ensemblgenomes.org/id/BAE77676 EnsemblBacteria b3616 http://www.ensemblgenomes.org/id/b3616 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008198 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0008743 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008743 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_function GO:0046870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046870 GO_process GO:0006564 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006564 GO_process GO:0006567 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006567 GO_process GO:0019518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019518 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 Gene3D 3.90.180.10 http://www.cathdb.info/version/latest/superfamily/3.90.180.10 GeneID 948139 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948139 HAMAP MF_00627 http://hamap.expasy.org/unirule/MF_00627 HOGENOM HOG000294686 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000294686&db=HOGENOM6 InParanoid P07913 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P07913 IntAct P07913 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P07913* IntEnz 1.1.1.103 {ECO:0000255|HAMAP-Rule:MF_00627, ECO:0000269|PubMed:6780553} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.103 {ECO:0000255|HAMAP-Rule:MF_00627, ECO:0000269|PubMed:6780553} InterPro IPR002085 http://www.ebi.ac.uk/interpro/entry/IPR002085 InterPro IPR002328 http://www.ebi.ac.uk/interpro/entry/IPR002328 InterPro IPR004627 http://www.ebi.ac.uk/interpro/entry/IPR004627 InterPro IPR011032 http://www.ebi.ac.uk/interpro/entry/IPR011032 InterPro IPR013149 http://www.ebi.ac.uk/interpro/entry/IPR013149 InterPro IPR013154 http://www.ebi.ac.uk/interpro/entry/IPR013154 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR020843 http://www.ebi.ac.uk/interpro/entry/IPR020843 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3591 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3591 KEGG_Gene eco:b3616 http://www.genome.jp/dbget-bin/www_bget?eco:b3616 KEGG_Orthology KO:K00060 http://www.genome.jp/dbget-bin/www_bget?KO:K00060 KEGG_Pathway ko00260 http://www.genome.jp/kegg-bin/show_pathway?ko00260 KEGG_Reaction rn:R01465 http://www.genome.jp/dbget-bin/www_bget?rn:R01465 OMA DGIFAEY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DGIFAEY PANTHER PTHR11695 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11695 PROSITE PS00059 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00059 PSORT swissprot:TDH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TDH_ECOLI PSORT-B swissprot:TDH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TDH_ECOLI PSORT2 swissprot:TDH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TDH_ECOLI Pfam PF00107 http://pfam.xfam.org/family/PF00107 Pfam PF08240 http://pfam.xfam.org/family/PF08240 Phobius swissprot:TDH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TDH_ECOLI PhylomeDB P07913 http://phylomedb.org/?seqid=P07913 ProteinModelPortal P07913 http://www.proteinmodelportal.org/query/uniprot/P07913 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2007567 http://www.ncbi.nlm.nih.gov/pubmed/2007567 PubMed 2647748 http://www.ncbi.nlm.nih.gov/pubmed/2647748 PubMed 6780553 http://www.ncbi.nlm.nih.gov/pubmed/6780553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9784233 http://www.ncbi.nlm.nih.gov/pubmed/9784233 RefSeq NP_418073 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418073 RefSeq WP_000646007 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000646007 SMART SM00829 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00829 SMR P07913 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P07913 STRING 511145.b3616 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3616&targetmode=cogs STRING COG1063 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1063&targetmode=cogs SUPFAM SSF50129 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50129 SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 TIGRFAMs TIGR00692 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00692 UniProtKB TDH_ECOLI http://www.uniprot.org/uniprot/TDH_ECOLI UniProtKB-AC P07913 http://www.uniprot.org/uniprot/P07913 charge swissprot:TDH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TDH_ECOLI eggNOG COG1063 http://eggnogapi.embl.de/nog_data/html/tree/COG1063 eggNOG ENOG4105CPQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CPQ epestfind swissprot:TDH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TDH_ECOLI garnier swissprot:TDH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TDH_ECOLI helixturnhelix swissprot:TDH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TDH_ECOLI hmoment swissprot:TDH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TDH_ECOLI iep swissprot:TDH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TDH_ECOLI inforesidue swissprot:TDH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TDH_ECOLI octanol swissprot:TDH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TDH_ECOLI pepcoil swissprot:TDH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TDH_ECOLI pepdigest swissprot:TDH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TDH_ECOLI pepinfo swissprot:TDH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TDH_ECOLI pepnet swissprot:TDH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TDH_ECOLI pepstats swissprot:TDH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TDH_ECOLI pepwheel swissprot:TDH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TDH_ECOLI pepwindow swissprot:TDH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TDH_ECOLI sigcleave swissprot:TDH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TDH_ECOLI ## Database ID URL or Descriptions # BioGrid 4263142 12 # EcoGene EG13092 ygdQ # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR005496 Integral_membrane_TerC # Organism YGDQ_ECOLI Escherichia coli (strain K12) # PATRIC 32121082 VBIEscCol129921_2930 # PIR A65066 A65066 # Pfam PF03741 TerC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGDQ_ECOLI UPF0053 inner membrane protein YgdQ # RefSeq NP_417309 NC_000913.3 # RefSeq WP_000895624 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0053 family. {ECO 0000305}. # SUBCELLULAR LOCATION YGDQ_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG COG0861 LUCA # eggNOG ENOG4105EE5 Bacteria BLAST swissprot:YGDQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGDQ_ECOLI BioCyc ECOL316407:JW2800-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2800-MONOMER BioCyc EcoCyc:G7460-MONOMER http://biocyc.org/getid?id=EcoCyc:G7460-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 EchoBASE EB2897 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2897 EcoGene EG13092 http://www.ecogene.org/geneInfo.php?eg_id=EG13092 EnsemblBacteria AAC75871 http://www.ensemblgenomes.org/id/AAC75871 EnsemblBacteria AAC75871 http://www.ensemblgenomes.org/id/AAC75871 EnsemblBacteria BAE76901 http://www.ensemblgenomes.org/id/BAE76901 EnsemblBacteria BAE76901 http://www.ensemblgenomes.org/id/BAE76901 EnsemblBacteria BAE76901 http://www.ensemblgenomes.org/id/BAE76901 EnsemblBacteria b2832 http://www.ensemblgenomes.org/id/b2832 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 947295 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947295 HOGENOM HOG000258483 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000258483&db=HOGENOM6 InParanoid P67127 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P67127 InterPro IPR005496 http://www.ebi.ac.uk/interpro/entry/IPR005496 KEGG_Gene ecj:JW2800 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2800 KEGG_Gene eco:b2832 http://www.genome.jp/dbget-bin/www_bget?eco:b2832 OMA VHSFFGA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VHSFFGA PSORT swissprot:YGDQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGDQ_ECOLI PSORT-B swissprot:YGDQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGDQ_ECOLI PSORT2 swissprot:YGDQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGDQ_ECOLI Pfam PF03741 http://pfam.xfam.org/family/PF03741 Phobius swissprot:YGDQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGDQ_ECOLI PhylomeDB P67127 http://phylomedb.org/?seqid=P67127 ProteinModelPortal P67127 http://www.proteinmodelportal.org/query/uniprot/P67127 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417309 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417309 RefSeq WP_000895624 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000895624 STRING 511145.b2832 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2832&targetmode=cogs UniProtKB YGDQ_ECOLI http://www.uniprot.org/uniprot/YGDQ_ECOLI UniProtKB-AC P67127 http://www.uniprot.org/uniprot/P67127 charge swissprot:YGDQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGDQ_ECOLI eggNOG COG0861 http://eggnogapi.embl.de/nog_data/html/tree/COG0861 eggNOG ENOG4105EE5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EE5 epestfind swissprot:YGDQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGDQ_ECOLI garnier swissprot:YGDQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGDQ_ECOLI helixturnhelix swissprot:YGDQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGDQ_ECOLI hmoment swissprot:YGDQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGDQ_ECOLI iep swissprot:YGDQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGDQ_ECOLI inforesidue swissprot:YGDQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGDQ_ECOLI octanol swissprot:YGDQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGDQ_ECOLI pepcoil swissprot:YGDQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGDQ_ECOLI pepdigest swissprot:YGDQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGDQ_ECOLI pepinfo swissprot:YGDQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGDQ_ECOLI pepnet swissprot:YGDQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGDQ_ECOLI pepstats swissprot:YGDQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGDQ_ECOLI pepwheel swissprot:YGDQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGDQ_ECOLI pepwindow swissprot:YGDQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGDQ_ECOLI sigcleave swissprot:YGDQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGDQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4259868 17 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG11770 ybbD # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # Organism YBBD_ECOLI Escherichia coli (strain K12) # PIR C64781 C64781 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBBD_ECOLI Putative uncharacterized protein YbbD # RefSeq WP_001320180 NZ_LN832404.1 # SUBCELLULAR LOCATION YBBD_ECOLI Membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. BLAST swissprot:YBBD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBBD_ECOLI BioCyc ECOL316407:JW0489-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0489-MONOMER BioCyc EcoCyc:EG11770-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11770-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/19.25.7177 http://dx.doi.org/10.1093/nar/19.25.7177 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL X60999 http://www.ebi.ac.uk/ena/data/view/X60999 EchoBASE EB1720 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1720 EcoGene EG11770 http://www.ecogene.org/geneInfo.php?eg_id=EG11770 EnsemblBacteria BAE76279 http://www.ensemblgenomes.org/id/BAE76279 EnsemblBacteria BAE76279 http://www.ensemblgenomes.org/id/BAE76279 EnsemblBacteria BAE76279 http://www.ensemblgenomes.org/id/BAE76279 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 HOGENOM HOG000076823 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000076823&db=HOGENOM6 KEGG_Gene ecj:JW0489 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0489 OMA GGYINIH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GGYINIH PSORT swissprot:YBBD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBBD_ECOLI PSORT-B swissprot:YBBD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBBD_ECOLI PSORT2 swissprot:YBBD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBBD_ECOLI Phobius swissprot:YBBD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBBD_ECOLI ProteinModelPortal P33669 http://www.proteinmodelportal.org/query/uniprot/P33669 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1766878 http://www.ncbi.nlm.nih.gov/pubmed/1766878 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001320180 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001320180 STRING 316407.85674639 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85674639&targetmode=cogs UniProtKB YBBD_ECOLI http://www.uniprot.org/uniprot/YBBD_ECOLI UniProtKB-AC P33669 http://www.uniprot.org/uniprot/P33669 charge swissprot:YBBD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBBD_ECOLI epestfind swissprot:YBBD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBBD_ECOLI garnier swissprot:YBBD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBBD_ECOLI helixturnhelix swissprot:YBBD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBBD_ECOLI hmoment swissprot:YBBD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBBD_ECOLI iep swissprot:YBBD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBBD_ECOLI inforesidue swissprot:YBBD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBBD_ECOLI octanol swissprot:YBBD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBBD_ECOLI pepcoil swissprot:YBBD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBBD_ECOLI pepdigest swissprot:YBBD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBBD_ECOLI pepinfo swissprot:YBBD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBBD_ECOLI pepnet swissprot:YBBD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBBD_ECOLI pepstats swissprot:YBBD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBBD_ECOLI pepwheel swissprot:YBBD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBBD_ECOLI pepwindow swissprot:YBBD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBBD_ECOLI sigcleave swissprot:YBBD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBBD_ECOLI ## Database ID URL or Descriptions # AltName UXAB_ECOLI Tagaturonate dehydrogenase # AltName UXAB_ECOLI Tagaturonate reductase # BioGrid 4260230 7 # CATALYTIC ACTIVITY UXAB_ECOLI D-altronate + NAD(+) = D-tagaturonate + NADH. # EcoGene EG11065 uxaB # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0009026 tagaturonate reductase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0051287 NAD binding; IDA:EcoCyc. # GO_process GO:0019698 D-galacturonate catabolic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.1040.10 -; 1. # Gene3D 3.40.50.720 -; 1. # HAMAP MF_00670 Altron_oxidoreduct # INDUCTION UXAB_ECOLI By galacturonate, tagaturonate and fructuronate. Its expression is subjected to catabolite repression by glucose. # IntAct P0A6L7 7 # InterPro IPR008927 6-PGluconate_DH_C-like # InterPro IPR013118 Mannitol_DH_C # InterPro IPR013131 Mannitol_DH_N # InterPro IPR013328 6PGD_dom_2 # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR023668 Altronate_OxRdtase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00040 Pentose and glucuronate interconversions # Organism UXAB_ECOLI Escherichia coli (strain K12) # PATHWAY UXAB_ECOLI Carbohydrate metabolism; pentose and glucuronate interconversion. # PATRIC 32118338 VBIEscCol129921_1589 # PIR D64906 D64906 # Pfam PF01232 Mannitol_dh # Pfam PF08125 Mannitol_dh_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UXAB_ECOLI Altronate oxidoreductase # RefSeq WP_000854633 NZ_LN832404.1 # RefSeq YP_025302 NC_000913.3 # SIMILARITY Belongs to the mannitol dehydrogenase family. UxaB subfamily. {ECO 0000305}. # SUPFAM SSF48179 SSF48179 # SUPFAM SSF51735 SSF51735 # eggNOG COG0246 LUCA # eggNOG ENOG4107QZW Bacteria BLAST swissprot:UXAB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UXAB_ECOLI BioCyc ECOL316407:JW1514-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1514-MONOMER BioCyc EcoCyc:ALTRO-OXIDOREDUCT-MONOMER http://biocyc.org/getid?id=EcoCyc:ALTRO-OXIDOREDUCT-MONOMER BioCyc MetaCyc:ALTRO-OXIDOREDUCT-MONOMER http://biocyc.org/getid?id=MetaCyc:ALTRO-OXIDOREDUCT-MONOMER COG COG0246 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0246 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1099/00221287-132-3-697 http://dx.doi.org/10.1099/00221287-132-3-697 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.58 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.58 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D13327 http://www.ebi.ac.uk/ena/data/view/D13327 EMBL M15737 http://www.ebi.ac.uk/ena/data/view/M15737 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.1.1.58 http://enzyme.expasy.org/EC/1.1.1.58 EchoBASE EB1058 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1058 EcoGene EG11065 http://www.ecogene.org/geneInfo.php?eg_id=EG11065 EnsemblBacteria AAT48131 http://www.ensemblgenomes.org/id/AAT48131 EnsemblBacteria AAT48131 http://www.ensemblgenomes.org/id/AAT48131 EnsemblBacteria BAA15204 http://www.ensemblgenomes.org/id/BAA15204 EnsemblBacteria BAA15204 http://www.ensemblgenomes.org/id/BAA15204 EnsemblBacteria BAA15204 http://www.ensemblgenomes.org/id/BAA15204 EnsemblBacteria b1521 http://www.ensemblgenomes.org/id/b1521 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0009026 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009026 GO_function GO:0051287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051287 GO_process GO:0019698 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019698 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.1040.10 http://www.cathdb.info/version/latest/superfamily/1.10.1040.10 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 945542 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945542 HAMAP MF_00670 http://hamap.expasy.org/unirule/MF_00670 HOGENOM HOG000029586 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000029586&db=HOGENOM6 InParanoid P0A6L7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6L7 IntAct P0A6L7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6L7* IntEnz 1.1.1.58 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.58 InterPro IPR008927 http://www.ebi.ac.uk/interpro/entry/IPR008927 InterPro IPR013118 http://www.ebi.ac.uk/interpro/entry/IPR013118 InterPro IPR013131 http://www.ebi.ac.uk/interpro/entry/IPR013131 InterPro IPR013328 http://www.ebi.ac.uk/interpro/entry/IPR013328 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR023668 http://www.ebi.ac.uk/interpro/entry/IPR023668 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1514 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1514 KEGG_Gene eco:b1521 http://www.genome.jp/dbget-bin/www_bget?eco:b1521 KEGG_Orthology KO:K00041 http://www.genome.jp/dbget-bin/www_bget?KO:K00041 KEGG_Pathway ko00040 http://www.genome.jp/kegg-bin/show_pathway?ko00040 KEGG_Reaction rn:R02555 http://www.genome.jp/dbget-bin/www_bget?rn:R02555 OMA VVIVRPI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VVIVRPI PSORT swissprot:UXAB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UXAB_ECOLI PSORT-B swissprot:UXAB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UXAB_ECOLI PSORT2 swissprot:UXAB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UXAB_ECOLI Pfam PF01232 http://pfam.xfam.org/family/PF01232 Pfam PF08125 http://pfam.xfam.org/family/PF08125 Phobius swissprot:UXAB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UXAB_ECOLI PhylomeDB P0A6L7 http://phylomedb.org/?seqid=P0A6L7 ProteinModelPortal P0A6L7 http://www.proteinmodelportal.org/query/uniprot/P0A6L7 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3525742 http://www.ncbi.nlm.nih.gov/pubmed/3525742 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000854633 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000854633 RefSeq YP_025302 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_025302 STRING 511145.b1521 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1521&targetmode=cogs STRING COG0246 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0246&targetmode=cogs SUPFAM SSF48179 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48179 SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB UXAB_ECOLI http://www.uniprot.org/uniprot/UXAB_ECOLI UniProtKB-AC P0A6L7 http://www.uniprot.org/uniprot/P0A6L7 charge swissprot:UXAB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UXAB_ECOLI eggNOG COG0246 http://eggnogapi.embl.de/nog_data/html/tree/COG0246 eggNOG ENOG4107QZW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QZW epestfind swissprot:UXAB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UXAB_ECOLI garnier swissprot:UXAB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UXAB_ECOLI helixturnhelix swissprot:UXAB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UXAB_ECOLI hmoment swissprot:UXAB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UXAB_ECOLI iep swissprot:UXAB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UXAB_ECOLI inforesidue swissprot:UXAB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UXAB_ECOLI octanol swissprot:UXAB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UXAB_ECOLI pepcoil swissprot:UXAB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UXAB_ECOLI pepdigest swissprot:UXAB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UXAB_ECOLI pepinfo swissprot:UXAB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UXAB_ECOLI pepnet swissprot:UXAB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UXAB_ECOLI pepstats swissprot:UXAB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UXAB_ECOLI pepwheel swissprot:UXAB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UXAB_ECOLI pepwindow swissprot:UXAB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UXAB_ECOLI sigcleave swissprot:UXAB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UXAB_ECOLI ## Database ID URL or Descriptions # AltName LIGB_ECOLI Polydeoxyribonucleotide synthase [NAD(+)] B # BioGrid 4262567 167 # CATALYTIC ACTIVITY LIGB_ECOLI NAD(+) + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + beta-nicotinamide D- ribonucleotide + (deoxyribonucleotide)(n+m). # COFACTOR LIGB_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 11812821}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 11812821}; # EcoGene EG11334 ligB # FUNCTION LIGB_ECOLI Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. {ECO 0000269|PubMed 11812821}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0003911 DNA ligase (NAD+) activity; IDA:EcoCyc. # GO_process GO:0006260 DNA replication; IEA:UniProtKB-KW. # GO_process GO:0006266 DNA ligation; IDA:EcoCyc. # GO_process GO:0006288 base-excision repair, DNA ligation; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016874 ligase activity # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0009058 biosynthetic process # HAMAP MF_01587 DNA_ligase_B # IntAct P25772 3 # InterPro IPR004150 NAD_DNA_ligase_OB # InterPro IPR010994 RuvA_2-like # InterPro IPR012340 NA-bd_OB-fold # InterPro IPR013839 DNAligase_adenylation # InterPro IPR013840 DNAligase_N # InterPro IPR018239 DNA_ligase_AS # InterPro IPR020923 DNA_ligase_B # InterPro IPR033136 DNA_ligase_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03032 DNA replication proteins # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko03030 DNA replication # KEGG_Pathway ko03410 Base excision repair # KEGG_Pathway ko03420 Nucleotide excision repair # KEGG_Pathway ko03430 Mismatch repair # MISCELLANEOUS LIGB_ECOLI Considerably less active in nick joining than LigA. # Organism LIGB_ECOLI Escherichia coli (strain K12) # PATRIC 32122781 VBIEscCol129921_3767 # PIR A65166 A65166 # PROSITE PS01055 DNA_LIGASE_N1 # PROSITE PS01056 DNA_LIGASE_N2 # Pfam PF01653 DNA_ligase_aden # Pfam PF03120 DNA_ligase_OB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LIGB_ECOLI DNA ligase B # RefSeq NP_418104 NC_000913.3 # RefSeq WP_000870036 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA62000.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAB88710.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the NAD-dependent DNA ligase family. LigB subfamily. {ECO 0000305}. # SMART SM00532 LIGANc # SUPFAM SSF47781 SSF47781 # SUPFAM SSF50249 SSF50249 # eggNOG COG0272 LUCA # eggNOG ENOG410649J Bacteria BLAST swissprot:LIGB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LIGB_ECOLI BioCyc ECOL316407:JW3622-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3622-MONOMER BioCyc EcoCyc:EG11334-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11334-MONOMER BioCyc MetaCyc:EG11334-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11334-MONOMER COG COG0272 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0272 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/29.24.4930 http://dx.doi.org/10.1093/nar/29.24.4930 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.5.1.2 http://www.genome.jp/dbget-bin/www_bget?EC:6.5.1.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M84400 http://www.ebi.ac.uk/ena/data/view/M84400 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 6.5.1.2 http://enzyme.expasy.org/EC/6.5.1.2 EchoBASE EB1310 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1310 EcoGene EG11334 http://www.ecogene.org/geneInfo.php?eg_id=EG11334 EnsemblBacteria AAC76671 http://www.ensemblgenomes.org/id/AAC76671 EnsemblBacteria AAC76671 http://www.ensemblgenomes.org/id/AAC76671 EnsemblBacteria BAE77646 http://www.ensemblgenomes.org/id/BAE77646 EnsemblBacteria BAE77646 http://www.ensemblgenomes.org/id/BAE77646 EnsemblBacteria BAE77646 http://www.ensemblgenomes.org/id/BAE77646 EnsemblBacteria b3647 http://www.ensemblgenomes.org/id/b3647 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003911 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003911 GO_process GO:0006260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260 GO_process GO:0006266 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006266 GO_process GO:0006288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006288 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 948164 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948164 HAMAP MF_01587 http://hamap.expasy.org/unirule/MF_01587 HOGENOM HOG000267776 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267776&db=HOGENOM6 IntAct P25772 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P25772* IntEnz 6.5.1.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.5.1.2 InterPro IPR004150 http://www.ebi.ac.uk/interpro/entry/IPR004150 InterPro IPR010994 http://www.ebi.ac.uk/interpro/entry/IPR010994 InterPro IPR012340 http://www.ebi.ac.uk/interpro/entry/IPR012340 InterPro IPR013839 http://www.ebi.ac.uk/interpro/entry/IPR013839 InterPro IPR013840 http://www.ebi.ac.uk/interpro/entry/IPR013840 InterPro IPR018239 http://www.ebi.ac.uk/interpro/entry/IPR018239 InterPro IPR020923 http://www.ebi.ac.uk/interpro/entry/IPR020923 InterPro IPR033136 http://www.ebi.ac.uk/interpro/entry/IPR033136 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03032 http://www.genome.jp/dbget-bin/www_bget?ko03032 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW3622 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3622 KEGG_Gene eco:b3647 http://www.genome.jp/dbget-bin/www_bget?eco:b3647 KEGG_Orthology KO:K01972 http://www.genome.jp/dbget-bin/www_bget?KO:K01972 KEGG_Pathway ko03030 http://www.genome.jp/kegg-bin/show_pathway?ko03030 KEGG_Pathway ko03410 http://www.genome.jp/kegg-bin/show_pathway?ko03410 KEGG_Pathway ko03420 http://www.genome.jp/kegg-bin/show_pathway?ko03420 KEGG_Pathway ko03430 http://www.genome.jp/kegg-bin/show_pathway?ko03430 OMA LFVWDWP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LFVWDWP PROSITE PS01055 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01055 PROSITE PS01056 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01056 PSORT swissprot:LIGB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LIGB_ECOLI PSORT-B swissprot:LIGB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LIGB_ECOLI PSORT2 swissprot:LIGB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LIGB_ECOLI Pfam PF01653 http://pfam.xfam.org/family/PF01653 Pfam PF03120 http://pfam.xfam.org/family/PF03120 Phobius swissprot:LIGB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LIGB_ECOLI PhylomeDB P25772 http://phylomedb.org/?seqid=P25772 ProteinModelPortal P25772 http://www.proteinmodelportal.org/query/uniprot/P25772 PubMed 11812821 http://www.ncbi.nlm.nih.gov/pubmed/11812821 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 8390989 http://www.ncbi.nlm.nih.gov/pubmed/8390989 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418104 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418104 RefSeq WP_000870036 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000870036 SMART SM00532 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00532 SMR P25772 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P25772 STRING 511145.b3647 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3647&targetmode=cogs STRING COG0272 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0272&targetmode=cogs SUPFAM SSF47781 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47781 SUPFAM SSF50249 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50249 UniProtKB LIGB_ECOLI http://www.uniprot.org/uniprot/LIGB_ECOLI UniProtKB-AC P25772 http://www.uniprot.org/uniprot/P25772 charge swissprot:LIGB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LIGB_ECOLI eggNOG COG0272 http://eggnogapi.embl.de/nog_data/html/tree/COG0272 eggNOG ENOG410649J http://eggnogapi.embl.de/nog_data/html/tree/ENOG410649J epestfind swissprot:LIGB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LIGB_ECOLI garnier swissprot:LIGB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LIGB_ECOLI helixturnhelix swissprot:LIGB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LIGB_ECOLI hmoment swissprot:LIGB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LIGB_ECOLI iep swissprot:LIGB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LIGB_ECOLI inforesidue swissprot:LIGB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LIGB_ECOLI octanol swissprot:LIGB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LIGB_ECOLI pepcoil swissprot:LIGB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LIGB_ECOLI pepdigest swissprot:LIGB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LIGB_ECOLI pepinfo swissprot:LIGB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LIGB_ECOLI pepnet swissprot:LIGB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LIGB_ECOLI pepstats swissprot:LIGB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LIGB_ECOLI pepwheel swissprot:LIGB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LIGB_ECOLI pepwindow swissprot:LIGB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LIGB_ECOLI sigcleave swissprot:LIGB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LIGB_ECOLI ## Database ID URL or Descriptions # AltName ASNA_ECOLI Asparagine synthetase A # BioGrid 4263263 101 # CATALYTIC ACTIVITY ASNA_ECOLI ATP + L-aspartate + NH(3) = AMP + diphosphate + L-asparagine. # CDD cd00645 AsnA # DISRUPTION PHENOTYPE Loss of production of extracellular death factor. {ECO:0000269|PubMed 17962566}. # EcoGene EG10091 asnA # FUNCTION ASNA_ECOLI May amidate Asp of the extracellular death factor precursor Asn-Asn-Trp-Asp-Asn to generate Asn-Asn-Trp-Asn-Asn. {ECO 0000305|PubMed 17962566}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004071 aspartate-ammonia ligase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006529 asparagine biosynthetic process; IDA:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0070981 L-asparagine biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # HAMAP MF_00555 AsnA # IntAct P00963 5 # InterPro IPR004618 AsnA # InterPro IPR006195 aa-tRNA-synth_II # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00250 Alanine, aspartate and glutamate metabolism # KEGG_Pathway ko00460 Cyanoamino acid metabolism # KEGG_Pathway ko00910 Nitrogen metabolism # Organism ASNA_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-asparagine biosynthesis; L- asparagine from L-aspartate (ammonia route) step 1/1. # PATRIC 32122987 VBIEscCol129921_3869 # PDB 11AS X-ray; 2.50 A; A/B=1-330 # PDB 12AS X-ray; 2.20 A; A/B=1-330 # PIR A01191 AJECNA # PIRSF PIRSF001555 Asp_ammon_ligase # PROSITE PS50862 AA_TRNA_LIGASE_II # Pfam PF03590 AsnA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ASNA_ECOLI Aspartate--ammonia ligase # RefSeq NP_418200 NC_000913.3 # RefSeq WP_000845104 NZ_LN832404.1 # RefSeq YP_006952153 NC_019049.1 # SIMILARITY Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION ASNA_ECOLI Cytoplasm. # SUBUNIT ASNA_ECOLI Homodimer. # TIGRFAMs TIGR00669 asnA # UniPathway UPA00134 UER00194 # eggNOG COG2502 LUCA # eggNOG ENOG4105CU9 Bacteria BLAST swissprot:ASNA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ASNA_ECOLI BioCyc ECOL316407:JW3722-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3722-MONOMER BioCyc EcoCyc:ASNSYNA-MONOMER http://biocyc.org/getid?id=EcoCyc:ASNSYNA-MONOMER BioCyc MetaCyc:ASNSYNA-MONOMER http://biocyc.org/getid?id=MetaCyc:ASNSYNA-MONOMER COG COG2502 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2502 DIP DIP-9176N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9176N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1016/0378-1119(83)90087-2 http://dx.doi.org/10.1016/0378-1119(83)90087-2 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb0198-15 http://dx.doi.org/10.1038/nsb0198-15 DOI 10.1093/nar/9.18.4669 http://dx.doi.org/10.1093/nar/9.18.4669 DOI 10.1126/science.1147248 http://dx.doi.org/10.1126/science.1147248 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1271/bbb.56.376 http://dx.doi.org/10.1271/bbb.56.376 EC_number EC:6.3.1.1 http://www.genome.jp/dbget-bin/www_bget?EC:6.3.1.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01657 http://www.ebi.ac.uk/ena/data/view/J01657 EMBL K00826 http://www.ebi.ac.uk/ena/data/view/K00826 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M10679 http://www.ebi.ac.uk/ena/data/view/M10679 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00263 http://www.ebi.ac.uk/ena/data/view/V00263 ENZYME 6.3.1.1 http://enzyme.expasy.org/EC/6.3.1.1 EchoBASE EB0089 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0089 EcoGene EG10091 http://www.ecogene.org/geneInfo.php?eg_id=EG10091 EnsemblBacteria AAC76767 http://www.ensemblgenomes.org/id/AAC76767 EnsemblBacteria AAC76767 http://www.ensemblgenomes.org/id/AAC76767 EnsemblBacteria BAE77544 http://www.ensemblgenomes.org/id/BAE77544 EnsemblBacteria BAE77544 http://www.ensemblgenomes.org/id/BAE77544 EnsemblBacteria BAE77544 http://www.ensemblgenomes.org/id/BAE77544 EnsemblBacteria b3744 http://www.ensemblgenomes.org/id/b3744 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004071 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006529 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006529 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0070981 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070981 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 13905103 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13905103 GeneID 948258 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948258 HAMAP MF_00555 http://hamap.expasy.org/unirule/MF_00555 HOGENOM HOG000284502 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000284502&db=HOGENOM6 InParanoid P00963 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00963 IntAct P00963 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00963* IntEnz 6.3.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.1.1 InterPro IPR004618 http://www.ebi.ac.uk/interpro/entry/IPR004618 InterPro IPR006195 http://www.ebi.ac.uk/interpro/entry/IPR006195 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3722 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3722 KEGG_Gene eco:b3744 http://www.genome.jp/dbget-bin/www_bget?eco:b3744 KEGG_Orthology KO:K01914 http://www.genome.jp/dbget-bin/www_bget?KO:K01914 KEGG_Pathway ko00250 http://www.genome.jp/kegg-bin/show_pathway?ko00250 KEGG_Pathway ko00460 http://www.genome.jp/kegg-bin/show_pathway?ko00460 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Reaction rn:R00483 http://www.genome.jp/dbget-bin/www_bget?rn:R00483 OMA QSRICMF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QSRICMF PDB 11AS http://www.ebi.ac.uk/pdbe-srv/view/entry/11AS PDB 12AS http://www.ebi.ac.uk/pdbe-srv/view/entry/12AS PDBsum 11AS http://www.ebi.ac.uk/pdbsum/11AS PDBsum 12AS http://www.ebi.ac.uk/pdbsum/12AS PROSITE PS50862 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50862 PSORT swissprot:ASNA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ASNA_ECOLI PSORT-B swissprot:ASNA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ASNA_ECOLI PSORT2 swissprot:ASNA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ASNA_ECOLI Pfam PF03590 http://pfam.xfam.org/family/PF03590 Phobius swissprot:ASNA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ASNA_ECOLI PhylomeDB P00963 http://phylomedb.org/?seqid=P00963 ProteinModelPortal P00963 http://www.proteinmodelportal.org/query/uniprot/P00963 PubMed 1369484 http://www.ncbi.nlm.nih.gov/pubmed/1369484 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17962566 http://www.ncbi.nlm.nih.gov/pubmed/17962566 PubMed 383377 http://www.ncbi.nlm.nih.gov/pubmed/383377 PubMed 6117826 http://www.ncbi.nlm.nih.gov/pubmed/6117826 PubMed 6357950 http://www.ncbi.nlm.nih.gov/pubmed/6357950 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9437423 http://www.ncbi.nlm.nih.gov/pubmed/9437423 RefSeq NP_418200 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418200 RefSeq WP_000845104 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000845104 RefSeq YP_006952153 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_006952153 SMR P00963 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00963 STRING 511145.b3744 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3744&targetmode=cogs STRING COG2502 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2502&targetmode=cogs SWISS-2DPAGE P00963 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P00963 TIGRFAMs TIGR00669 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00669 UniProtKB ASNA_ECOLI http://www.uniprot.org/uniprot/ASNA_ECOLI UniProtKB-AC P00963 http://www.uniprot.org/uniprot/P00963 charge swissprot:ASNA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ASNA_ECOLI eggNOG COG2502 http://eggnogapi.embl.de/nog_data/html/tree/COG2502 eggNOG ENOG4105CU9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CU9 epestfind swissprot:ASNA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ASNA_ECOLI garnier swissprot:ASNA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ASNA_ECOLI helixturnhelix swissprot:ASNA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ASNA_ECOLI hmoment swissprot:ASNA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ASNA_ECOLI iep swissprot:ASNA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ASNA_ECOLI inforesidue swissprot:ASNA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ASNA_ECOLI octanol swissprot:ASNA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ASNA_ECOLI pepcoil swissprot:ASNA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ASNA_ECOLI pepdigest swissprot:ASNA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ASNA_ECOLI pepinfo swissprot:ASNA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ASNA_ECOLI pepnet swissprot:ASNA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ASNA_ECOLI pepstats swissprot:ASNA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ASNA_ECOLI pepwheel swissprot:ASNA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ASNA_ECOLI pepwindow swissprot:ASNA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ASNA_ECOLI sigcleave swissprot:ASNA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ASNA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260576 13 # EcoGene EG14171 eutL # FUNCTION EUTL_ECOLI May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place. # GO_component GO:0031471 ethanolamine degradation polyhedral organelle; ISS:EcoCyc. # GO_function GO:0005198 structural molecule activity; ISS:EcoCyc. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_process GO:0009605 response to external stimulus; IEA:InterPro. # GO_process GO:0046336 ethanolamine catabolic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0043226 organelle # GOslim_function GO:0005198 structural molecule activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # InterPro IPR000249 Microcompartment_bac # InterPro IPR009193 EutL_PduB # InterPro IPR030983 EutL # Organism EUTL_ECOLI Escherichia coli (strain K12) # PATHWAY EUTL_ECOLI Amine and polyamine degradation; ethanolamine degradation. # PATRIC 32120263 VBIEscCol129921_2534 # PDB 3GFH X-ray; 2.20 A; A/B=1-219 # PDB 3I82 X-ray; 2.31 A; A=1-219 # PDB 3I87 X-ray; 2.30 A; A=1-219 # PDB 3MPV X-ray; 2.60 A; A/B=1-219 # PIR F65018 F65018 # PIRSF PIRSF012290 EutL_PduB # Pfam PF00936 BMC; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EUTL_ECOLI Ethanolamine utilization protein EutL # RefSeq NP_416934 NC_000913.3 # RefSeq WP_001111023 NZ_LN832404.1 # SIMILARITY Belongs to the EutL/PduB family. {ECO 0000305}. # SMART SM00877 BMC; 2 # TIGRFAMs TIGR04502 microcomp_EutL # eggNOG COG4816 LUCA # eggNOG ENOG4106D67 Bacteria BLAST swissprot:EUTL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EUTL_ECOLI BioCyc ECOL316407:JW2432-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2432-MONOMER BioCyc EcoCyc:G7271-MONOMER http://biocyc.org/getid?id=EcoCyc:G7271-MONOMER COG COG4816 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4816 DIP DIP-9536N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9536N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3923 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3923 EcoGene EG14171 http://www.ecogene.org/geneInfo.php?eg_id=EG14171 EnsemblBacteria AAC75492 http://www.ensemblgenomes.org/id/AAC75492 EnsemblBacteria AAC75492 http://www.ensemblgenomes.org/id/AAC75492 EnsemblBacteria BAE76715 http://www.ensemblgenomes.org/id/BAE76715 EnsemblBacteria BAE76715 http://www.ensemblgenomes.org/id/BAE76715 EnsemblBacteria BAE76715 http://www.ensemblgenomes.org/id/BAE76715 EnsemblBacteria b2439 http://www.ensemblgenomes.org/id/b2439 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0031471 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031471 GO_function GO:0005198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005198 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_process GO:0009605 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009605 GO_process GO:0046336 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046336 GOslim_component GO:0043226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226 GOslim_function GO:0005198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005198 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 946914 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946914 HOGENOM HOG000289069 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000289069&db=HOGENOM6 InParanoid P76541 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76541 IntAct P76541 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76541* InterPro IPR000249 http://www.ebi.ac.uk/interpro/entry/IPR000249 InterPro IPR009193 http://www.ebi.ac.uk/interpro/entry/IPR009193 InterPro IPR030983 http://www.ebi.ac.uk/interpro/entry/IPR030983 KEGG_Gene ecj:JW2432 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2432 KEGG_Gene eco:b2439 http://www.genome.jp/dbget-bin/www_bget?eco:b2439 KEGG_Orthology KO:K04026 http://www.genome.jp/dbget-bin/www_bget?KO:K04026 OMA KSFYGGA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KSFYGGA PDB 3GFH http://www.ebi.ac.uk/pdbe-srv/view/entry/3GFH PDB 3I82 http://www.ebi.ac.uk/pdbe-srv/view/entry/3I82 PDB 3I87 http://www.ebi.ac.uk/pdbe-srv/view/entry/3I87 PDB 3MPV http://www.ebi.ac.uk/pdbe-srv/view/entry/3MPV PDBsum 3GFH http://www.ebi.ac.uk/pdbsum/3GFH PDBsum 3I82 http://www.ebi.ac.uk/pdbsum/3I82 PDBsum 3I87 http://www.ebi.ac.uk/pdbsum/3I87 PDBsum 3MPV http://www.ebi.ac.uk/pdbsum/3MPV PSORT swissprot:EUTL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EUTL_ECOLI PSORT-B swissprot:EUTL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EUTL_ECOLI PSORT2 swissprot:EUTL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EUTL_ECOLI Pfam PF00936 http://pfam.xfam.org/family/PF00936 Phobius swissprot:EUTL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EUTL_ECOLI ProteinModelPortal P76541 http://www.proteinmodelportal.org/query/uniprot/P76541 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416934 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416934 RefSeq WP_001111023 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001111023 SMART SM00877 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00877 SMR P76541 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76541 STRING 511145.b2439 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2439&targetmode=cogs STRING COG4816 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4816&targetmode=cogs TIGRFAMs TIGR04502 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR04502 UniProtKB EUTL_ECOLI http://www.uniprot.org/uniprot/EUTL_ECOLI UniProtKB-AC P76541 http://www.uniprot.org/uniprot/P76541 charge swissprot:EUTL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EUTL_ECOLI eggNOG COG4816 http://eggnogapi.embl.de/nog_data/html/tree/COG4816 eggNOG ENOG4106D67 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106D67 epestfind swissprot:EUTL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EUTL_ECOLI garnier swissprot:EUTL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EUTL_ECOLI helixturnhelix swissprot:EUTL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EUTL_ECOLI hmoment swissprot:EUTL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EUTL_ECOLI iep swissprot:EUTL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EUTL_ECOLI inforesidue swissprot:EUTL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EUTL_ECOLI octanol swissprot:EUTL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EUTL_ECOLI pepcoil swissprot:EUTL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EUTL_ECOLI pepdigest swissprot:EUTL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EUTL_ECOLI pepinfo swissprot:EUTL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EUTL_ECOLI pepnet swissprot:EUTL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EUTL_ECOLI pepstats swissprot:EUTL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EUTL_ECOLI pepwheel swissprot:EUTL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EUTL_ECOLI pepwindow swissprot:EUTL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EUTL_ECOLI sigcleave swissprot:EUTL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EUTL_ECOLI ## Database ID URL or Descriptions # BioGrid 4262791 148 # EcoGene EG11391 osmY # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_component GO:0042597 periplasmic space; IDA:EcoCyc. # GO_process GO:0006970 response to osmotic stress; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0006950 response to stress # INDUCTION OSMY_ECOLI By elevated osmotic pressure in the growth medium. # IntAct P0AFH8 3 # InterPro IPR007055 BON_dom # InterPro IPR014004 Transpt-assoc_nodulatn_dom_bac # Organism OSMY_ECOLI Escherichia coli (strain K12) # PATRIC 32124362 VBIEscCol129921_4521 # PIR A41899 A41899 # PROSITE PS50914 BON; 2 # Pfam PF04972 BON; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName OSMY_ECOLI Osmotically-inducible protein Y # RefSeq NP_418793 NC_000913.3 # RefSeq WP_001295748 NZ_LN832404.1 # SIMILARITY Contains 2 BON domains. {ECO:0000255|PROSITE- ProRule PRU00229}. # SMART SM00749 BON; 2 # SUBCELLULAR LOCATION OSMY_ECOLI Periplasm. # eggNOG COG2823 LUCA # eggNOG ENOG4105K3G Bacteria BLAST swissprot:OSMY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:OSMY_ECOLI BioCyc ECOL316407:JW4338-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4338-MONOMER BioCyc EcoCyc:EG11391-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11391-MONOMER COG COG2823 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2823 DIP DIP-47968N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47968N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1998.1726 http://dx.doi.org/10.1006/jmbi.1998.1726 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M89635 http://www.ebi.ac.uk/ena/data/view/M89635 EMBL S67278 http://www.ebi.ac.uk/ena/data/view/S67278 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB1364 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1364 EcoGene EG11391 http://www.ecogene.org/geneInfo.php?eg_id=EG11391 EnsemblBacteria AAC77329 http://www.ensemblgenomes.org/id/AAC77329 EnsemblBacteria AAC77329 http://www.ensemblgenomes.org/id/AAC77329 EnsemblBacteria BAE78364 http://www.ensemblgenomes.org/id/BAE78364 EnsemblBacteria BAE78364 http://www.ensemblgenomes.org/id/BAE78364 EnsemblBacteria BAE78364 http://www.ensemblgenomes.org/id/BAE78364 EnsemblBacteria b4376 http://www.ensemblgenomes.org/id/b4376 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_process GO:0006970 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006970 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 948895 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948895 HOGENOM HOG000127831 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000127831&db=HOGENOM6 InParanoid P0AFH8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFH8 IntAct P0AFH8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFH8* InterPro IPR007055 http://www.ebi.ac.uk/interpro/entry/IPR007055 InterPro IPR014004 http://www.ebi.ac.uk/interpro/entry/IPR014004 KEGG_Gene ecj:JW4338 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4338 KEGG_Gene eco:b4376 http://www.genome.jp/dbget-bin/www_bget?eco:b4376 KEGG_Orthology KO:K04065 http://www.genome.jp/dbget-bin/www_bget?KO:K04065 OMA DISVKTH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DISVKTH PROSITE PS50914 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50914 PSORT swissprot:OSMY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:OSMY_ECOLI PSORT-B swissprot:OSMY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:OSMY_ECOLI PSORT2 swissprot:OSMY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:OSMY_ECOLI Pfam PF04972 http://pfam.xfam.org/family/PF04972 Phobius swissprot:OSMY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:OSMY_ECOLI PhylomeDB P0AFH8 http://phylomedb.org/?seqid=P0AFH8 ProteinModelPortal P0AFH8 http://www.proteinmodelportal.org/query/uniprot/P0AFH8 PubMed 1317380 http://www.ncbi.nlm.nih.gov/pubmed/1317380 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8253679 http://www.ncbi.nlm.nih.gov/pubmed/8253679 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 RefSeq NP_418793 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418793 RefSeq WP_001295748 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295748 SMART SM00749 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00749 SMR P0AFH8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFH8 STRING 511145.b4376 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4376&targetmode=cogs STRING COG2823 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2823&targetmode=cogs UniProtKB OSMY_ECOLI http://www.uniprot.org/uniprot/OSMY_ECOLI UniProtKB-AC P0AFH8 http://www.uniprot.org/uniprot/P0AFH8 charge swissprot:OSMY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:OSMY_ECOLI eggNOG COG2823 http://eggnogapi.embl.de/nog_data/html/tree/COG2823 eggNOG ENOG4105K3G http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K3G epestfind swissprot:OSMY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:OSMY_ECOLI garnier swissprot:OSMY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:OSMY_ECOLI helixturnhelix swissprot:OSMY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:OSMY_ECOLI hmoment swissprot:OSMY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:OSMY_ECOLI iep swissprot:OSMY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:OSMY_ECOLI inforesidue swissprot:OSMY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:OSMY_ECOLI octanol swissprot:OSMY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:OSMY_ECOLI pepcoil swissprot:OSMY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:OSMY_ECOLI pepdigest swissprot:OSMY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:OSMY_ECOLI pepinfo swissprot:OSMY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:OSMY_ECOLI pepnet swissprot:OSMY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:OSMY_ECOLI pepstats swissprot:OSMY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:OSMY_ECOLI pepwheel swissprot:OSMY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:OSMY_ECOLI pepwindow swissprot:OSMY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:OSMY_ECOLI sigcleave swissprot:OSMY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:OSMY_ECOLI ## Database ID URL or Descriptions # AltName MALZ_ECOLI Alpha-glucosidase # BRENDA 3.2.1.20 2026 # BioGrid 4263268 9 # CATALYTIC ACTIVITY MALZ_ECOLI Hydrolysis of terminal, non-reducing (1->4)- linked alpha-D-glucose residues with release of alpha-D-glucose. # CAZy CBM34 Carbohydrate-Binding Module Family 34 # CAZy GH13 Glycoside Hydrolase Family 13 # CDD cd02857 E_set_CDase_PDE_N # EcoGene EG10565 malZ # FUNCTION MALZ_ECOLI May play a role in regulating the intracellular level of maltotriose. Cleaves glucose from the reducing end of maltotriose and longer maltodextrins with a chain length of up to 7 glucose units. # GO_component GO:0005737 cytoplasm; IDA:EcoCyc. # GO_function GO:0004558 alpha-1,4-glucosidase activity; IDA:EcoCyc. # GO_function GO:0032450 maltose alpha-glucosidase activity; IEA:UniProtKB-EC. # GO_process GO:0030980 alpha-glucan catabolic process; IDA:EcoCyc. # GO_process GO:0051692 cellular oligosaccharide catabolic process; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # Gene3D 2.60.40.1180 -; 1. # Gene3D 3.20.20.80 -; 1. # INDUCTION MALZ_ECOLI Under positive control of MalT. # IntAct P21517 8 # InterPro IPR004185 Glyco_hydro_13_lg-like_dom # InterPro IPR006047 Glyco_hydro_13_cat_dom # InterPro IPR013780 Glyco_hydro_b # InterPro IPR013781 Glyco_hydro_catalytic_dom # InterPro IPR014756 Ig_E-set # InterPro IPR015902 Glyco_hydro_13 # InterPro IPR017069 MalZ # InterPro IPR017853 Glycoside_hydrolase_SF # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00052 Galactose metabolism # KEGG_Pathway ko00500 Starch and sucrose metabolism # Organism MALZ_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10357 PTHR10357; 2 # PATRIC 32115955 VBIEscCol129921_0419 # PDB 5BN7 X-ray; 3.70 A; A=1-604 # PIR C64769 C64769 # PIRSF PIRSF036918 Maltodextrin_glucosidase # Pfam PF00128 Alpha-amylase # Pfam PF02903 Alpha-amylase_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MALZ_ECOLI Maltodextrin glucosidase # RefSeq NP_414937 NC_000913.3 # SEQUENCE CAUTION Sequence=AAB40159.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAE76183.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the glycosyl hydrolase 13 family. {ECO 0000305}. # SMART SM00642 Aamy # SUBCELLULAR LOCATION MALZ_ECOLI Cytoplasm. # SUBUNIT MALZ_ECOLI Monomer. # SUPFAM SSF51445 SSF51445 # SUPFAM SSF81296 SSF81296 # eggNOG COG0366 LUCA # eggNOG ENOG4107R28 Bacteria BLAST swissprot:MALZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MALZ_ECOLI BioCyc ECOL316407:JW0393-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0393-MONOMER BioCyc EcoCyc:MALTODEXGLUCOSID-MONOMER http://biocyc.org/getid?id=EcoCyc:MALTODEXGLUCOSID-MONOMER BioCyc MetaCyc:MALTODEXGLUCOSID-MONOMER http://biocyc.org/getid?id=MetaCyc:MALTODEXGLUCOSID-MONOMER COG COG0366 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0366 DIP DIP-10152N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10152N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.2.1.20 http://www.genome.jp/dbget-bin/www_bget?EC:3.2.1.20 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M37702 http://www.ebi.ac.uk/ena/data/view/M37702 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL X59839 http://www.ebi.ac.uk/ena/data/view/X59839 ENZYME 3.2.1.20 http://enzyme.expasy.org/EC/3.2.1.20 EchoBASE EB0560 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0560 EcoGene EG10565 http://www.ecogene.org/geneInfo.php?eg_id=EG10565 EnsemblBacteria AAC73506 http://www.ensemblgenomes.org/id/AAC73506 EnsemblBacteria AAC73506 http://www.ensemblgenomes.org/id/AAC73506 EnsemblBacteria BAE76183 http://www.ensemblgenomes.org/id/BAE76183 EnsemblBacteria BAE76183 http://www.ensemblgenomes.org/id/BAE76183 EnsemblBacteria BAE76183 http://www.ensemblgenomes.org/id/BAE76183 EnsemblBacteria b0403 http://www.ensemblgenomes.org/id/b0403 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004558 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004558 GO_function GO:0032450 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032450 GO_process GO:0030980 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030980 GO_process GO:0051692 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051692 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 2.60.40.1180 http://www.cathdb.info/version/latest/superfamily/2.60.40.1180 Gene3D 3.20.20.80 http://www.cathdb.info/version/latest/superfamily/3.20.20.80 GeneID 949131 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949131 HOGENOM HOG000055363 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000055363&db=HOGENOM6 InParanoid P21517 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P21517 IntAct P21517 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P21517* IntEnz 3.2.1.20 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.2.1.20 InterPro IPR004185 http://www.ebi.ac.uk/interpro/entry/IPR004185 InterPro IPR006047 http://www.ebi.ac.uk/interpro/entry/IPR006047 InterPro IPR013780 http://www.ebi.ac.uk/interpro/entry/IPR013780 InterPro IPR013781 http://www.ebi.ac.uk/interpro/entry/IPR013781 InterPro IPR014756 http://www.ebi.ac.uk/interpro/entry/IPR014756 InterPro IPR015902 http://www.ebi.ac.uk/interpro/entry/IPR015902 InterPro IPR017069 http://www.ebi.ac.uk/interpro/entry/IPR017069 InterPro IPR017853 http://www.ebi.ac.uk/interpro/entry/IPR017853 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0393 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0393 KEGG_Gene eco:b0403 http://www.genome.jp/dbget-bin/www_bget?eco:b0403 KEGG_Orthology KO:K01187 http://www.genome.jp/dbget-bin/www_bget?KO:K01187 KEGG_Pathway ko00052 http://www.genome.jp/kegg-bin/show_pathway?ko00052 KEGG_Pathway ko00500 http://www.genome.jp/kegg-bin/show_pathway?ko00500 KEGG_Reaction rn:R00028 http://www.genome.jp/dbget-bin/www_bget?rn:R00028 KEGG_Reaction rn:R00801 http://www.genome.jp/dbget-bin/www_bget?rn:R00801 KEGG_Reaction rn:R00802 http://www.genome.jp/dbget-bin/www_bget?rn:R00802 KEGG_Reaction rn:R06087 http://www.genome.jp/dbget-bin/www_bget?rn:R06087 KEGG_Reaction rn:R06088 http://www.genome.jp/dbget-bin/www_bget?rn:R06088 MINT MINT-1219352 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1219352 OMA GNNDPFC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GNNDPFC PANTHER PTHR10357 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10357 PDB 5BN7 http://www.ebi.ac.uk/pdbe-srv/view/entry/5BN7 PDBsum 5BN7 http://www.ebi.ac.uk/pdbsum/5BN7 PSORT swissprot:MALZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MALZ_ECOLI PSORT-B swissprot:MALZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MALZ_ECOLI PSORT2 swissprot:MALZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MALZ_ECOLI Pfam PF00128 http://pfam.xfam.org/family/PF00128 Pfam PF02903 http://pfam.xfam.org/family/PF02903 Phobius swissprot:MALZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MALZ_ECOLI ProteinModelPortal P21517 http://www.proteinmodelportal.org/query/uniprot/P21517 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1706703 http://www.ncbi.nlm.nih.gov/pubmed/1706703 PubMed 1918057 http://www.ncbi.nlm.nih.gov/pubmed/1918057 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414937 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414937 SMART SM00642 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00642 SMR P21517 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P21517 STRING 511145.b0403 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0403&targetmode=cogs STRING COG0366 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0366&targetmode=cogs SUPFAM SSF51445 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51445 SUPFAM SSF81296 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81296 UniProtKB MALZ_ECOLI http://www.uniprot.org/uniprot/MALZ_ECOLI UniProtKB-AC P21517 http://www.uniprot.org/uniprot/P21517 charge swissprot:MALZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MALZ_ECOLI eggNOG COG0366 http://eggnogapi.embl.de/nog_data/html/tree/COG0366 eggNOG ENOG4107R28 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107R28 epestfind swissprot:MALZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MALZ_ECOLI garnier swissprot:MALZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MALZ_ECOLI helixturnhelix swissprot:MALZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MALZ_ECOLI hmoment swissprot:MALZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MALZ_ECOLI iep swissprot:MALZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MALZ_ECOLI inforesidue swissprot:MALZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MALZ_ECOLI octanol swissprot:MALZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MALZ_ECOLI pepcoil swissprot:MALZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MALZ_ECOLI pepdigest swissprot:MALZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MALZ_ECOLI pepinfo swissprot:MALZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MALZ_ECOLI pepnet swissprot:MALZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MALZ_ECOLI pepstats swissprot:MALZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MALZ_ECOLI pepwheel swissprot:MALZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MALZ_ECOLI pepwindow swissprot:MALZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MALZ_ECOLI sigcleave swissprot:MALZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MALZ_ECOLI ## Database ID URL or Descriptions # BioGrid 4261064 8 # EcoGene EG13356 zntB # FUNCTION ZNTB_ECOLI Mediates efflux of zinc ions. {ECO 0000255|HAMAP- Rule MF_01565}. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0005385 zinc ion transmembrane transporter activity; IEA:InterPro. # GO_function GO:0046873 metal ion transmembrane transporter activity; IBA:GO_Central. # GO_process GO:0098655 cation transmembrane transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0055085 transmembrane transport # HAMAP MF_01565 ZntB # InterPro IPR002523 MgTranspt_CorA/ZnTranspt_ZntB # InterPro IPR023714 Zn_transp_ZntB # KEGG_Brite ko02000 Transporters # Organism ZNTB_ECOLI Escherichia coli (strain K12) # PATRIC 32117962 VBIEscCol129921_1401 # PIR A64884 A64884 # Pfam PF01544 CorA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Zinc transport protein ZntB {ECO:0000255|HAMAP-Rule MF_01565} # RefSeq NP_415858 NC_000913.3 # RefSeq WP_000387388 NZ_LN832404.1 # SIMILARITY Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family. {ECO:0000255|HAMAP-Rule MF_01565}. # SUBCELLULAR LOCATION ZNTB_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG COG0598 LUCA # eggNOG ENOG4107RX3 Bacteria BLAST swissprot:ZNTB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ZNTB_ECOLI BioCyc ECOL316407:JW1336-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1336-MONOMER BioCyc EcoCyc:G6674-MONOMER http://biocyc.org/getid?id=EcoCyc:G6674-MONOMER COG COG0598 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0598 DIP DIP-48038N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48038N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3139 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3139 EcoGene EG13356 http://www.ecogene.org/geneInfo.php?eg_id=EG13356 EnsemblBacteria AAC74424 http://www.ensemblgenomes.org/id/AAC74424 EnsemblBacteria AAC74424 http://www.ensemblgenomes.org/id/AAC74424 EnsemblBacteria BAE76406 http://www.ensemblgenomes.org/id/BAE76406 EnsemblBacteria BAE76406 http://www.ensemblgenomes.org/id/BAE76406 EnsemblBacteria BAE76406 http://www.ensemblgenomes.org/id/BAE76406 EnsemblBacteria b1342 http://www.ensemblgenomes.org/id/b1342 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0005385 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005385 GO_function GO:0046873 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046873 GO_process GO:0098655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098655 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 945910 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945910 HAMAP MF_01565 http://hamap.expasy.org/unirule/MF_01565 HOGENOM HOG000271325 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000271325&db=HOGENOM6 InParanoid P64423 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P64423 IntAct P64423 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P64423* InterPro IPR002523 http://www.ebi.ac.uk/interpro/entry/IPR002523 InterPro IPR023714 http://www.ebi.ac.uk/interpro/entry/IPR023714 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1336 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1336 KEGG_Gene eco:b1342 http://www.genome.jp/dbget-bin/www_bget?eco:b1342 KEGG_Orthology KO:K16074 http://www.genome.jp/dbget-bin/www_bget?KO:K16074 OMA EHPCWLH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EHPCWLH PSORT swissprot:ZNTB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ZNTB_ECOLI PSORT-B swissprot:ZNTB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ZNTB_ECOLI PSORT2 swissprot:ZNTB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ZNTB_ECOLI Pfam PF01544 http://pfam.xfam.org/family/PF01544 Phobius swissprot:ZNTB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ZNTB_ECOLI PhylomeDB P64423 http://phylomedb.org/?seqid=P64423 ProteinModelPortal P64423 http://www.proteinmodelportal.org/query/uniprot/P64423 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415858 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415858 RefSeq WP_000387388 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000387388 SMR P64423 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P64423 STRING 511145.b1342 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1342&targetmode=cogs STRING COG0598 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0598&targetmode=cogs UniProtKB ZNTB_ECOLI http://www.uniprot.org/uniprot/ZNTB_ECOLI UniProtKB-AC P64423 http://www.uniprot.org/uniprot/P64423 charge swissprot:ZNTB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ZNTB_ECOLI eggNOG COG0598 http://eggnogapi.embl.de/nog_data/html/tree/COG0598 eggNOG ENOG4107RX3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107RX3 epestfind swissprot:ZNTB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ZNTB_ECOLI garnier swissprot:ZNTB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ZNTB_ECOLI helixturnhelix swissprot:ZNTB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ZNTB_ECOLI hmoment swissprot:ZNTB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ZNTB_ECOLI iep swissprot:ZNTB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ZNTB_ECOLI inforesidue swissprot:ZNTB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ZNTB_ECOLI octanol swissprot:ZNTB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ZNTB_ECOLI pepcoil swissprot:ZNTB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ZNTB_ECOLI pepdigest swissprot:ZNTB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ZNTB_ECOLI pepinfo swissprot:ZNTB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ZNTB_ECOLI pepnet swissprot:ZNTB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ZNTB_ECOLI pepstats swissprot:ZNTB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ZNTB_ECOLI pepwheel swissprot:ZNTB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ZNTB_ECOLI pepwindow swissprot:ZNTB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ZNTB_ECOLI sigcleave swissprot:ZNTB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ZNTB_ECOLI ## Database ID URL or Descriptions # AltName GCL_ECOLI Tartronate-semialdehyde synthase # BRENDA 4.1.1.47 2165 # BioGrid 4263336 2 # CATALYTIC ACTIVITY GCL_ECOLI 2 glyoxylate = tartronate semialdehyde + CO(2). # COFACTOR GCL_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250}; Note=Binds 1 Mg(2+) ion per subunit. {ECO 0000250}; # COFACTOR GCL_ECOLI Name=thiamine diphosphate; Xref=ChEBI CHEBI 58937; Evidence={ECO 0000250}; Note=Binds 1 thiamine pyrophosphate per subunit. {ECO 0000250}; # EcoGene EG11583 gcl # FUNCTION GCL_ECOLI Catalyzes the condensation of two molecules of glyoxylate to give 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde). # GO_function GO:0000287 magnesium ion binding; IEA:InterPro. # GO_function GO:0009028 tartronate-semialdehyde synthase activity; IDA:EcoCyc. # GO_function GO:0030976 thiamine pyrophosphate binding; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0071949 FAD binding; IDA:EcoCyc. # GO_process GO:0009436 glyoxylate catabolic process; IMP:EcoCyc. # GO_process GO:0046296 glycolate catabolic process; IMP:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.1220 -; 1. # Gene3D 3.40.50.970 -; 2. # INDUCTION GCL_ECOLI By glyoxylate. # IntAct P0AEP7 6 # InterPro IPR006397 Glyox_carbo_lig # InterPro IPR011766 TPP_enzyme-bd_C # InterPro IPR012000 Thiamin_PyroP_enz_cen_dom # InterPro IPR012001 Thiamin_PyroP_enz_TPP-bd_dom # InterPro IPR029035 DHS-like_NAD/FAD-binding_dom # InterPro IPR029061 THDP-binding # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00630 Glyoxylate and dicarboxylate metabolism # Organism GCL_ECOLI Escherichia coli (strain K12) # PANTHER PTHR18968:SF14 PTHR18968:SF14 # PATHWAY Organic acid metabolism; glycolate degradation; 3- phospho-D-glycerate from glycolate step 2/4. # PATRIC 32116173 VBIEscCol129921_0528 # PDB 2PAN X-ray; 2.70 A; A/B/C/D/E/F=1-593 # PIR JT0742 JT0742 # Pfam PF00205 TPP_enzyme_M # Pfam PF02775 TPP_enzyme_C # Pfam PF02776 TPP_enzyme_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GCL_ECOLI Glyoxylate carboligase # RefSeq NP_415040 NC_000913.3 # RefSeq WP_001096881 NZ_CP014272.1 # SEQUENCE CAUTION Sequence=AAB40260.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the TPP enzyme family. {ECO 0000305}. # SUBUNIT GCL_ECOLI Homotetramer. # SUPFAM SSF52467 SSF52467 # SUPFAM SSF52518 SSF52518; 2 # TIGRFAMs TIGR01504 glyox_carbo_lig # UniPathway UPA00864 UER00831 # eggNOG COG3960 LUCA # eggNOG ENOG41060W2 Bacteria BLAST swissprot:GCL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GCL_ECOLI BioCyc ECOL316407:JW0495-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0495-MONOMER BioCyc EcoCyc:GLYOCARBOLIG-MONOMER http://biocyc.org/getid?id=EcoCyc:GLYOCARBOLIG-MONOMER BioCyc MetaCyc:GLYOCARBOLIG-MONOMER http://biocyc.org/getid?id=MetaCyc:GLYOCARBOLIG-MONOMER COG COG0028 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0028 DIP DIP-48112N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48112N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.1.1.47 http://www.genome.jp/dbget-bin/www_bget?EC:4.1.1.47 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L03845 http://www.ebi.ac.uk/ena/data/view/L03845 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 ENZYME 4.1.1.47 http://enzyme.expasy.org/EC/4.1.1.47 EchoBASE EB1542 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1542 EcoGene EG11583 http://www.ecogene.org/geneInfo.php?eg_id=EG11583 EnsemblBacteria AAC73609 http://www.ensemblgenomes.org/id/AAC73609 EnsemblBacteria AAC73609 http://www.ensemblgenomes.org/id/AAC73609 EnsemblBacteria BAE76285 http://www.ensemblgenomes.org/id/BAE76285 EnsemblBacteria BAE76285 http://www.ensemblgenomes.org/id/BAE76285 EnsemblBacteria BAE76285 http://www.ensemblgenomes.org/id/BAE76285 EnsemblBacteria b0507 http://www.ensemblgenomes.org/id/b0507 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0009028 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009028 GO_function GO:0030976 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030976 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0071949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071949 GO_process GO:0009436 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009436 GO_process GO:0046296 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046296 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.1220 http://www.cathdb.info/version/latest/superfamily/3.40.50.1220 Gene3D 3.40.50.970 http://www.cathdb.info/version/latest/superfamily/3.40.50.970 GeneID 945394 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945394 HOGENOM HOG000258449 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000258449&db=HOGENOM6 InParanoid P0AEP7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEP7 IntAct P0AEP7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEP7* IntEnz 4.1.1.47 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.1.47 InterPro IPR006397 http://www.ebi.ac.uk/interpro/entry/IPR006397 InterPro IPR011766 http://www.ebi.ac.uk/interpro/entry/IPR011766 InterPro IPR012000 http://www.ebi.ac.uk/interpro/entry/IPR012000 InterPro IPR012001 http://www.ebi.ac.uk/interpro/entry/IPR012001 InterPro IPR029035 http://www.ebi.ac.uk/interpro/entry/IPR029035 InterPro IPR029061 http://www.ebi.ac.uk/interpro/entry/IPR029061 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0495 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0495 KEGG_Gene eco:b0507 http://www.genome.jp/dbget-bin/www_bget?eco:b0507 KEGG_Orthology KO:K01608 http://www.genome.jp/dbget-bin/www_bget?KO:K01608 KEGG_Pathway ko00630 http://www.genome.jp/kegg-bin/show_pathway?ko00630 KEGG_Reaction rn:R00013 http://www.genome.jp/dbget-bin/www_bget?rn:R00013 MINT MINT-1302810 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1302810 OMA WGAIPDD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WGAIPDD PANTHER PTHR18968:SF14 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18968:SF14 PDB 2PAN http://www.ebi.ac.uk/pdbe-srv/view/entry/2PAN PDBsum 2PAN http://www.ebi.ac.uk/pdbsum/2PAN PSORT swissprot:GCL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GCL_ECOLI PSORT-B swissprot:GCL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GCL_ECOLI PSORT2 swissprot:GCL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GCL_ECOLI Pfam PF00205 http://pfam.xfam.org/family/PF00205 Pfam PF02775 http://pfam.xfam.org/family/PF02775 Pfam PF02776 http://pfam.xfam.org/family/PF02776 Phobius swissprot:GCL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GCL_ECOLI PhylomeDB P0AEP7 http://phylomedb.org/?seqid=P0AEP7 ProteinModelPortal P0AEP7 http://www.proteinmodelportal.org/query/uniprot/P0AEP7 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8440684 http://www.ncbi.nlm.nih.gov/pubmed/8440684 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415040 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415040 RefSeq WP_001096881 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001096881 SMR P0AEP7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEP7 STRING 511145.b0507 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0507&targetmode=cogs STRING COG0028 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0028&targetmode=cogs SUPFAM SSF52467 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52467 SUPFAM SSF52518 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52518 TIGRFAMs TIGR01504 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01504 UniProtKB GCL_ECOLI http://www.uniprot.org/uniprot/GCL_ECOLI UniProtKB-AC P0AEP7 http://www.uniprot.org/uniprot/P0AEP7 charge swissprot:GCL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GCL_ECOLI eggNOG COG3960 http://eggnogapi.embl.de/nog_data/html/tree/COG3960 eggNOG ENOG41060W2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41060W2 epestfind swissprot:GCL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GCL_ECOLI garnier swissprot:GCL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GCL_ECOLI helixturnhelix swissprot:GCL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GCL_ECOLI hmoment swissprot:GCL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GCL_ECOLI iep swissprot:GCL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GCL_ECOLI inforesidue swissprot:GCL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GCL_ECOLI octanol swissprot:GCL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GCL_ECOLI pepcoil swissprot:GCL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GCL_ECOLI pepdigest swissprot:GCL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GCL_ECOLI pepinfo swissprot:GCL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GCL_ECOLI pepnet swissprot:GCL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GCL_ECOLI pepstats swissprot:GCL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GCL_ECOLI pepwheel swissprot:GCL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GCL_ECOLI pepwindow swissprot:GCL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GCL_ECOLI sigcleave swissprot:GCL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GCL_ECOLI ## Database ID URL or Descriptions # AltName CBRC_ECOLI CreB-regulated gene C protein # BioGrid 4263198 3 # EcoGene EG11727 cbrC # GO_process GO:0030153 bacteriocin immunity; IMP:EcoCyc. # GOslim_process GO:0019748 secondary metabolic process # INDUCTION Induced by the two-component regulatory system CreC/CreB. {ECO:0000269|PubMed 11350954}. # IntAct P31469 14 # InterPro IPR005363 UPF0167 # MISCELLANEOUS CBRC_ECOLI Disruption of this gene leads to hypersensibility to nitrofurazone. # Organism CBRC_ECOLI Escherichia coli (strain K12) # PATRIC 32122929 VBIEscCol129921_3840 # PIR F65174 F65174 # Pfam PF03691 UPF0167 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CBRC_ECOLI UPF0167 protein CbrC # RefSeq NP_418173 NC_000913.3 # RefSeq WP_000193072 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0167 family. {ECO 0000305}. # eggNOG COG3196 LUCA # eggNOG ENOG4106611 Bacteria BLAST swissprot:CBRC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CBRC_ECOLI BioCyc ECOL316407:JW3695-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3695-MONOMER BioCyc EcoCyc:EG11727-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11727-MONOMER COG COG3196 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3196 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M011186200 http://dx.doi.org/10.1074/jbc.M011186200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.185.16.4956-4972.2003 http://dx.doi.org/10.1128/JB.185.16.4956-4972.2003 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1678 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1678 EcoGene EG11727 http://www.ecogene.org/geneInfo.php?eg_id=EG11727 EnsemblBacteria AAC76740 http://www.ensemblgenomes.org/id/AAC76740 EnsemblBacteria AAC76740 http://www.ensemblgenomes.org/id/AAC76740 EnsemblBacteria BAE77571 http://www.ensemblgenomes.org/id/BAE77571 EnsemblBacteria BAE77571 http://www.ensemblgenomes.org/id/BAE77571 EnsemblBacteria BAE77571 http://www.ensemblgenomes.org/id/BAE77571 EnsemblBacteria b3717 http://www.ensemblgenomes.org/id/b3717 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0030153 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030153 GOslim_process GO:0019748 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019748 GeneID 948230 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948230 HOGENOM HOG000296529 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000296529&db=HOGENOM6 InParanoid P31469 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31469 IntAct P31469 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31469* InterPro IPR005363 http://www.ebi.ac.uk/interpro/entry/IPR005363 KEGG_Gene ecj:JW3695 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3695 KEGG_Gene eco:b3717 http://www.genome.jp/dbget-bin/www_bget?eco:b3717 KEGG_Orthology KO:K09925 http://www.genome.jp/dbget-bin/www_bget?KO:K09925 OMA YLCPWCI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YLCPWCI PSORT swissprot:CBRC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CBRC_ECOLI PSORT-B swissprot:CBRC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CBRC_ECOLI PSORT2 swissprot:CBRC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CBRC_ECOLI Pfam PF03691 http://pfam.xfam.org/family/PF03691 Phobius swissprot:CBRC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CBRC_ECOLI PhylomeDB P31469 http://phylomedb.org/?seqid=P31469 ProteinModelPortal P31469 http://www.proteinmodelportal.org/query/uniprot/P31469 PubMed 11350954 http://www.ncbi.nlm.nih.gov/pubmed/11350954 PubMed 12897016 http://www.ncbi.nlm.nih.gov/pubmed/12897016 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418173 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418173 RefSeq WP_000193072 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000193072 STRING 511145.b3717 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3717&targetmode=cogs STRING COG3196 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3196&targetmode=cogs UniProtKB CBRC_ECOLI http://www.uniprot.org/uniprot/CBRC_ECOLI UniProtKB-AC P31469 http://www.uniprot.org/uniprot/P31469 charge swissprot:CBRC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CBRC_ECOLI eggNOG COG3196 http://eggnogapi.embl.de/nog_data/html/tree/COG3196 eggNOG ENOG4106611 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106611 epestfind swissprot:CBRC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CBRC_ECOLI garnier swissprot:CBRC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CBRC_ECOLI helixturnhelix swissprot:CBRC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CBRC_ECOLI hmoment swissprot:CBRC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CBRC_ECOLI iep swissprot:CBRC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CBRC_ECOLI inforesidue swissprot:CBRC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CBRC_ECOLI octanol swissprot:CBRC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CBRC_ECOLI pepcoil swissprot:CBRC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CBRC_ECOLI pepdigest swissprot:CBRC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CBRC_ECOLI pepinfo swissprot:CBRC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CBRC_ECOLI pepnet swissprot:CBRC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CBRC_ECOLI pepstats swissprot:CBRC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CBRC_ECOLI pepwheel swissprot:CBRC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CBRC_ECOLI pepwindow swissprot:CBRC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CBRC_ECOLI sigcleave swissprot:CBRC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CBRC_ECOLI ## Database ID URL or Descriptions # AltName ISPA_ECOLI (2E,6E)-farnesyl diphosphate synthase # AltName ISPA_ECOLI Geranyltranstransferase # BioGrid 4259837 457 # CATALYTIC ACTIVITY ISPA_ECOLI Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate. # COFACTOR ISPA_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 14672944}; Note=Binds 3 Mg(2+) ions per subunit. {ECO 0000269|PubMed 14672944}; # EcoGene EG10508 ispA # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004161 dimethylallyltranstransferase activity; IDA:EcoCyc. # GO_function GO:0004337 geranyltranstransferase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0033384 geranyl diphosphate biosynthetic process; IMP:EcoCyc. # GO_process GO:0045337 farnesyl diphosphate biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 1.10.600.10 -; 1. # INTERACTION ISPA_ECOLI P77609 flxA; NbExp=5; IntAct=EBI-553011, EBI-553024; P33221 purT; NbExp=3; IntAct=EBI-553011, EBI-553029; # IntAct P22939 16 # InterPro IPR000092 Polyprenyl_synt # InterPro IPR008949 Isoprenoid_synthase_dom # InterPro IPR033749 Polyprenyl_synt_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01006 Prenyltransferases # KEGG_Pathway ko00900 Terpenoid backbone biosynthesis # Organism ISPA_ECOLI Escherichia coli (strain K12) # PATRIC 32115991 VBIEscCol129921_0437 # PDB 1RQI X-ray; 2.42 A; A/B=1-299 # PDB 1RQJ X-ray; 1.95 A; A/B=1-299 # PIR JQ0665 JQ0665 # PROSITE PS00444 POLYPRENYL_SYNTHASE_2 # PROSITE PS00723 POLYPRENYL_SYNTHASE_1 # Pfam PF00348 polyprenyl_synt # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ISPA_ECOLI Farnesyl diphosphate synthase # RefSeq NP_414955 NC_000913.3 # RefSeq WP_000347217 NZ_LN832404.1 # SIMILARITY Belongs to the FPP/GGPP synthase family. {ECO 0000305}. # SUBCELLULAR LOCATION ISPA_ECOLI Cytoplasm. # SUPFAM SSF48576 SSF48576 # eggNOG COG0142 LUCA # eggNOG ENOG4105CTB Bacteria BLAST swissprot:ISPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ISPA_ECOLI BioCyc ECOL316407:JW0411-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0411-MONOMER BioCyc EcoCyc:FPPSYN-MONOMER http://biocyc.org/getid?id=EcoCyc:FPPSYN-MONOMER BioCyc MetaCyc:FPPSYN-MONOMER http://biocyc.org/getid?id=MetaCyc:FPPSYN-MONOMER COG COG0142 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0142 DIP DIP-10044N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10044N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.C300511200 http://dx.doi.org/10.1074/jbc.C300511200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.5.1.10 http://www.genome.jp/dbget-bin/www_bget?EC:2.5.1.10 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D00694 http://www.ebi.ac.uk/ena/data/view/D00694 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 ENZYME 2.5.1.10 http://enzyme.expasy.org/EC/2.5.1.10 EchoBASE EB0503 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0503 EcoGene EG10508 http://www.ecogene.org/geneInfo.php?eg_id=EG10508 EnsemblBacteria AAC73524 http://www.ensemblgenomes.org/id/AAC73524 EnsemblBacteria AAC73524 http://www.ensemblgenomes.org/id/AAC73524 EnsemblBacteria BAE76201 http://www.ensemblgenomes.org/id/BAE76201 EnsemblBacteria BAE76201 http://www.ensemblgenomes.org/id/BAE76201 EnsemblBacteria BAE76201 http://www.ensemblgenomes.org/id/BAE76201 EnsemblBacteria b0421 http://www.ensemblgenomes.org/id/b0421 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004161 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004161 GO_function GO:0004337 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004337 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0033384 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033384 GO_process GO:0045337 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045337 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016765 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 1.10.600.10 http://www.cathdb.info/version/latest/superfamily/1.10.600.10 GeneID 945064 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945064 HOGENOM HOG000009101 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009101&db=HOGENOM6 InParanoid P22939 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P22939 IntAct P22939 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P22939* IntEnz 2.5.1.10 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.5.1.10 InterPro IPR000092 http://www.ebi.ac.uk/interpro/entry/IPR000092 InterPro IPR008949 http://www.ebi.ac.uk/interpro/entry/IPR008949 InterPro IPR033749 http://www.ebi.ac.uk/interpro/entry/IPR033749 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01006 http://www.genome.jp/dbget-bin/www_bget?ko01006 KEGG_Gene ecj:JW0411 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0411 KEGG_Gene eco:b0421 http://www.genome.jp/dbget-bin/www_bget?eco:b0421 KEGG_Orthology KO:K00795 http://www.genome.jp/dbget-bin/www_bget?KO:K00795 KEGG_Pathway ko00900 http://www.genome.jp/kegg-bin/show_pathway?ko00900 KEGG_Reaction rn:R01658 http://www.genome.jp/dbget-bin/www_bget?rn:R01658 KEGG_Reaction rn:R02003 http://www.genome.jp/dbget-bin/www_bget?rn:R02003 MINT MINT-1233182 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1233182 OMA KSHAILE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KSHAILE PDB 1RQI http://www.ebi.ac.uk/pdbe-srv/view/entry/1RQI PDB 1RQJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1RQJ PDBsum 1RQI http://www.ebi.ac.uk/pdbsum/1RQI PDBsum 1RQJ http://www.ebi.ac.uk/pdbsum/1RQJ PROSITE PS00444 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00444 PROSITE PS00723 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00723 PSORT swissprot:ISPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ISPA_ECOLI PSORT-B swissprot:ISPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ISPA_ECOLI PSORT2 swissprot:ISPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ISPA_ECOLI Pfam PF00348 http://pfam.xfam.org/family/PF00348 Phobius swissprot:ISPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ISPA_ECOLI PhylomeDB P22939 http://phylomedb.org/?seqid=P22939 ProteinModelPortal P22939 http://www.proteinmodelportal.org/query/uniprot/P22939 PubMed 14672944 http://www.ncbi.nlm.nih.gov/pubmed/14672944 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2089044 http://www.ncbi.nlm.nih.gov/pubmed/2089044 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414955 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414955 RefSeq WP_000347217 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000347217 SMR P22939 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P22939 STRING 511145.b0421 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0421&targetmode=cogs STRING COG0142 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0142&targetmode=cogs SUPFAM SSF48576 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48576 SWISS-2DPAGE P22939 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P22939 UniProtKB ISPA_ECOLI http://www.uniprot.org/uniprot/ISPA_ECOLI UniProtKB-AC P22939 http://www.uniprot.org/uniprot/P22939 charge swissprot:ISPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ISPA_ECOLI eggNOG COG0142 http://eggnogapi.embl.de/nog_data/html/tree/COG0142 eggNOG ENOG4105CTB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CTB epestfind swissprot:ISPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ISPA_ECOLI garnier swissprot:ISPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ISPA_ECOLI helixturnhelix swissprot:ISPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ISPA_ECOLI hmoment swissprot:ISPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ISPA_ECOLI iep swissprot:ISPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ISPA_ECOLI inforesidue swissprot:ISPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ISPA_ECOLI octanol swissprot:ISPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ISPA_ECOLI pepcoil swissprot:ISPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ISPA_ECOLI pepdigest swissprot:ISPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ISPA_ECOLI pepinfo swissprot:ISPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ISPA_ECOLI pepnet swissprot:ISPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ISPA_ECOLI pepstats swissprot:ISPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ISPA_ECOLI pepwheel swissprot:ISPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ISPA_ECOLI pepwindow swissprot:ISPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ISPA_ECOLI sigcleave swissprot:ISPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ISPA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259962 77 # CATALYTIC ACTIVITY RHLE_ECOLI ATP + H(2)O = ADP + phosphate. {ECO 0000255|HAMAP-Rule MF_00968, ECO 0000269|PubMed 15196029}. # ENZYME REGULATION ATPase activity is stimulated by both long RNAs and short oligoribonucleotides. {ECO:0000269|PubMed 15196029}. # EcoGene EG11235 rhlE # FUNCTION RHLE_ECOLI DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA. May play a role in the interconversion of ribosomal RNA-folding intermediates that are further processed by DeaD or SrmB during ribosome maturation. {ECO 0000255|HAMAP-Rule MF_00968, ECO 0000269|PubMed 15196029, ECO 0000269|PubMed 18083833}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003723 RNA binding; IEA:UniProtKB-KW. # GO_function GO:0004004 ATP-dependent RNA helicase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_process GO:0009408 response to heat; IMP:EcoCyc. # GO_process GO:0010501 RNA secondary structure unwinding; IBA:GO_Central. # GO_process GO:0042255 ribosome assembly; IGI:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0004386 helicase activity # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0022618 ribonucleoprotein complex assembly # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.50.300 -; 2. # HAMAP MF_00968 DEAD_helicase_RhlE # INDUCTION Transiently induced by cold shock in a PNPase-dependent fashion. {ECO:0000269|PubMed 14527658}. # IntAct P25888 35 # InterPro IPR000629 RNA-helicase_DEAD-box_CS # InterPro IPR001650 Helicase_C # InterPro IPR011545 DEAD/DEAH_box_helicase_dom # InterPro IPR014001 Helicase_ATP-bd # InterPro IPR014014 RNA_helicase_DEAD_Q_motif # InterPro IPR027417 P-loop_NTPase # InterPro IPR028622 DEAD_helicase_RhlE # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko03018 RNA degradation # MISCELLANEOUS In vitro, can replace RhlB in degradosome and facilitate the degradation of RNA by PNPase. {ECO:0000305|PubMed 15554979}. # Organism RHLE_ECOLI Escherichia coli (strain K12) # PATRIC 32116795 VBIEscCol129921_0823 # PIR E64816 E64816 # PROSITE PS00039 DEAD_ATP_HELICASE # PROSITE PS51192 HELICASE_ATP_BIND_1 # PROSITE PS51194 HELICASE_CTER # PROSITE PS51195 Q_MOTIF # Pfam PF00270 DEAD # Pfam PF00271 Helicase_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ATP-dependent RNA helicase RhlE {ECO:0000255|HAMAP-Rule MF_00968} # RefSeq NP_415318 NC_000913.3 # RefSeq WP_000007101 NZ_LN832404.1 # SIMILARITY Belongs to the DEAD box helicase family. RhlE subfamily. {ECO:0000255|HAMAP-Rule MF_00968}. # SIMILARITY Contains 1 helicase ATP-binding domain. {ECO:0000255|HAMAP-Rule MF_00968}. # SIMILARITY Contains 1 helicase C-terminal domain. {ECO:0000255|HAMAP-Rule MF_00968}. # SMART SM00487 DEXDc # SMART SM00490 HELICc # SUBCELLULAR LOCATION RHLE_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00968, ECO 0000269|PubMed 18083833}. Note=Ribosome-associated. Can either bind to the intact 70S ribosome or to individual ribosomal subunits. # SUBUNIT RHLE_ECOLI Interacts with PcnB. Interacts in vitro with RNase E. {ECO 0000269|PubMed 10361280, ECO 0000269|PubMed 15554979}. # SUPFAM SSF52540 SSF52540 # eggNOG COG0513 LUCA # eggNOG ENOG4105C1J Bacteria BLAST swissprot:RHLE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RHLE_ECOLI BioCyc ECOL316407:JW0781-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0781-MONOMER BioCyc EcoCyc:EG11235-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11235-MONOMER COG COG0513 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0513 DIP DIP-10697N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10697N DOI 10.1016/S0923-2508(03)00167-0 http://dx.doi.org/10.1016/S0923-2508(03)00167-0 DOI 10.1021/bi049852s http://dx.doi.org/10.1021/bi049852s DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1999.01394.x http://dx.doi.org/10.1046/j.1365-2958.1999.01394.x DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.2004.04361.x http://dx.doi.org/10.1111/j.1365-2958.2004.04361.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1261/rna.800308 http://dx.doi.org/10.1261/rna.800308 DOI 10.1266/jjg.69.1 http://dx.doi.org/10.1266/jjg.69.1 EC_number EC:3.6.4.13 {ECO:0000255|HAMAP-Rule:MF_00968} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.4.13 {ECO:0000255|HAMAP-Rule:MF_00968} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L02123 http://www.ebi.ac.uk/ena/data/view/L02123 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X56307 http://www.ebi.ac.uk/ena/data/view/X56307 ENZYME 3.6.4.13 {ECO:0000255|HAMAP-Rule:MF_00968} http://enzyme.expasy.org/EC/3.6.4.13 {ECO:0000255|HAMAP-Rule:MF_00968} EchoBASE EB1217 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1217 EcoGene EG11235 http://www.ecogene.org/geneInfo.php?eg_id=EG11235 EnsemblBacteria AAC73884 http://www.ensemblgenomes.org/id/AAC73884 EnsemblBacteria AAC73884 http://www.ensemblgenomes.org/id/AAC73884 EnsemblBacteria BAA35457 http://www.ensemblgenomes.org/id/BAA35457 EnsemblBacteria BAA35457 http://www.ensemblgenomes.org/id/BAA35457 EnsemblBacteria BAA35457 http://www.ensemblgenomes.org/id/BAA35457 EnsemblBacteria b0797 http://www.ensemblgenomes.org/id/b0797 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0004004 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004004 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GO_process GO:0010501 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010501 GO_process GO:0042255 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042255 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0004386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004386 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0022618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022618 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945425 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945425 HAMAP MF_00968 http://hamap.expasy.org/unirule/MF_00968 HOGENOM HOG000268807 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000268807&db=HOGENOM6 InParanoid P25888 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P25888 IntAct P25888 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P25888* IntEnz 3.6.4.13 {ECO:0000255|HAMAP-Rule:MF_00968} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.4.13 {ECO:0000255|HAMAP-Rule:MF_00968} InterPro IPR000629 http://www.ebi.ac.uk/interpro/entry/IPR000629 InterPro IPR001650 http://www.ebi.ac.uk/interpro/entry/IPR001650 InterPro IPR011545 http://www.ebi.ac.uk/interpro/entry/IPR011545 InterPro IPR014001 http://www.ebi.ac.uk/interpro/entry/IPR014001 InterPro IPR014014 http://www.ebi.ac.uk/interpro/entry/IPR014014 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR028622 http://www.ebi.ac.uk/interpro/entry/IPR028622 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0781 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0781 KEGG_Gene eco:b0797 http://www.genome.jp/dbget-bin/www_bget?eco:b0797 KEGG_Orthology KO:K11927 http://www.genome.jp/dbget-bin/www_bget?KO:K11927 KEGG_Pathway ko03018 http://www.genome.jp/kegg-bin/show_pathway?ko03018 MINT MINT-1313387 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1313387 OMA HAPRKPQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HAPRKPQ PROSITE PS00039 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00039 PROSITE PS51192 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51192 PROSITE PS51194 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51194 PROSITE PS51195 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51195 PSORT swissprot:RHLE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RHLE_ECOLI PSORT-B swissprot:RHLE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RHLE_ECOLI PSORT2 swissprot:RHLE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RHLE_ECOLI Pfam PF00270 http://pfam.xfam.org/family/PF00270 Pfam PF00271 http://pfam.xfam.org/family/PF00271 Phobius swissprot:RHLE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RHLE_ECOLI PhylomeDB P25888 http://phylomedb.org/?seqid=P25888 ProteinModelPortal P25888 http://www.proteinmodelportal.org/query/uniprot/P25888 PubMed 10361280 http://www.ncbi.nlm.nih.gov/pubmed/10361280 PubMed 14527658 http://www.ncbi.nlm.nih.gov/pubmed/14527658 PubMed 15196029 http://www.ncbi.nlm.nih.gov/pubmed/15196029 PubMed 15554979 http://www.ncbi.nlm.nih.gov/pubmed/15554979 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18083833 http://www.ncbi.nlm.nih.gov/pubmed/18083833 PubMed 1931833 http://www.ncbi.nlm.nih.gov/pubmed/1931833 PubMed 8037924 http://www.ncbi.nlm.nih.gov/pubmed/8037924 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415318 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415318 RefSeq WP_000007101 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000007101 SMART SM00487 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00487 SMART SM00490 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00490 SMR P25888 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P25888 STRING 511145.b0797 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0797&targetmode=cogs STRING COG0513 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0513&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB RHLE_ECOLI http://www.uniprot.org/uniprot/RHLE_ECOLI UniProtKB-AC P25888 http://www.uniprot.org/uniprot/P25888 charge swissprot:RHLE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RHLE_ECOLI eggNOG COG0513 http://eggnogapi.embl.de/nog_data/html/tree/COG0513 eggNOG ENOG4105C1J http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C1J epestfind swissprot:RHLE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RHLE_ECOLI garnier swissprot:RHLE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RHLE_ECOLI helixturnhelix swissprot:RHLE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RHLE_ECOLI hmoment swissprot:RHLE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RHLE_ECOLI iep swissprot:RHLE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RHLE_ECOLI inforesidue swissprot:RHLE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RHLE_ECOLI octanol swissprot:RHLE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RHLE_ECOLI pepcoil swissprot:RHLE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RHLE_ECOLI pepdigest swissprot:RHLE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RHLE_ECOLI pepinfo swissprot:RHLE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RHLE_ECOLI pepnet swissprot:RHLE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RHLE_ECOLI pepstats swissprot:RHLE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RHLE_ECOLI pepwheel swissprot:RHLE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RHLE_ECOLI pepwindow swissprot:RHLE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RHLE_ECOLI sigcleave swissprot:RHLE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RHLE_ECOLI ## Database ID URL or Descriptions # CDD cd00349 Ribosomal_L11 # EcoGene EG10872 rplK # FUNCTION RL11_ECOLI Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0022625 cytosolic large ribosomal subunit; IDA:EcoCyc. # GO_function GO:0003735 structural constituent of ribosome; IBA:GO_Central. # GO_function GO:0019843 rRNA binding; IDA:EcoCyc. # GO_function GO:0070180 large ribosomal subunit rRNA binding; IEA:UniProtKB-HAMAP. # GO_process GO:0000027 ribosomal large subunit assembly; IBA:GO_Central. # GO_process GO:0006415 translational termination; IMP:EcoCyc. # GO_process GO:0015968 stringent response; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_function GO:0019843 rRNA binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0022618 ribonucleoprotein complex assembly # Gene3D 1.10.10.250 -; 1. # Gene3D 3.30.1550.10 -; 1. # HAMAP MF_00736 Ribosomal_L11 # INTERACTION RL11_ECOLI P0A8T1 prmA; NbExp=3; IntAct=EBI-547288, EBI-556300; # IntAct P0A7J7 46 # InterPro IPR000911 Ribosomal_L11/L12 # InterPro IPR006519 Ribosomal_L11_bac-typ # InterPro IPR020783 Ribosomal_L11_C # InterPro IPR020784 Ribosomal_L11_N # InterPro IPR020785 Ribosomal_L11_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 M00179 Ribosome, archaea # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=14870.2; Method=MALDI; Range=2-142; Evidence={ECO:0000269|PubMed 10094780}; # Organism RL11_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11661 PTHR11661 # PATRIC 32123487 VBIEscCol129921_4096 # PDB 1EG0 EM; 11.50 A; K=1-140 # PDB 1MJ1 EM; 13.00 A; L=1-141 # PDB 1ML5 EM; 14.00 A; l=1-141 # PDB 2J28 EM; 8.00 A; I=2-142 # PDB 2RDO EM; 9.10 A; I=2-142 # PDB 3DEG EM; -; H=2-142 # PDB 3EP2 EM; -; I=2-142 # PDB 3EQ3 EM; -; I=2-142 # PDB 3EQ4 EM; -; I=2-142 # PDB 3J0D EM; 11.10 A; G=2-142 # PDB 3J5L EM; 6.60 A; I=2-142 # PDB 3J7Z EM; 3.90 A; I=1-142 # PDB 3J8G EM; 5.00 A; I=1-142 # PDB 3J9Y EM; 3.90 A; I=1-142 # PDB 3J9Z EM; 3.60 A; LE=2-142 # PDB 3JA1 EM; 3.60 A; LK=2-142 # PDB 3JBV EM; 3.32 A; i=1-142 # PDB 3JCD EM; 3.70 A; I=1-142 # PDB 3JCE EM; 3.20 A; I=1-142 # PDB 3JCJ EM; 3.70 A; H=1-142 # PDB 3JCN EM; 4.60 A; I=1-142 # PDB 487D EM; 7.50 A; L=10-86 # PDB 4CSU EM; 5.50 A; I=2-142 # PDB 4U1U X-ray; 2.95 A; BI/DI=2-142 # PDB 4U1V X-ray; 3.00 A; BI/DI=2-142 # PDB 4U20 X-ray; 2.90 A; BI/DI=2-142 # PDB 4U24 X-ray; 2.90 A; BI/DI=2-142 # PDB 4U25 X-ray; 2.90 A; BI/DI=2-142 # PDB 4U26 X-ray; 2.80 A; BI/DI=2-142 # PDB 4U27 X-ray; 2.80 A; BI/DI=2-142 # PDB 4UY8 EM; 3.80 A; I=2-142 # PDB 4V47 EM; 12.30 A; AG=2-142 # PDB 4V48 EM; 11.50 A; AG=2-142 # PDB 4V4H X-ray; 3.46 A; BI/DI=1-142 # PDB 4V4Q X-ray; 3.46 A; BI/DI=2-142 # PDB 4V4V EM; 15.00 A; BG=3-141 # PDB 4V4W EM; 15.00 A; BG=3-141 # PDB 4V50 X-ray; 3.22 A; BI/DI=2-142 # PDB 4V52 X-ray; 3.21 A; BI/DI=2-142 # PDB 4V53 X-ray; 3.54 A; BI/DI=2-142 # PDB 4V54 X-ray; 3.30 A; BI/DI=2-142 # PDB 4V55 X-ray; 4.00 A; BI/DI=2-142 # PDB 4V56 X-ray; 3.93 A; BI/DI=2-142 # PDB 4V57 X-ray; 3.50 A; BI/DI=2-142 # PDB 4V5B X-ray; 3.74 A; AI/CI=2-142 # PDB 4V5H EM; 5.80 A; BI=2-142 # PDB 4V5Y X-ray; 4.45 A; BI/DI=2-142 # PDB 4V64 X-ray; 3.50 A; BI/DI=2-142 # PDB 4V65 EM; 9.00 A; B5=1-142 # PDB 4V66 EM; 9.00 A; B5=1-142 # PDB 4V69 EM; 6.70 A; BI=2-142 # PDB 4V6C X-ray; 3.19 A; BI/DI=1-142 # PDB 4V6D X-ray; 3.81 A; BI/DI=1-142 # PDB 4V6E X-ray; 3.71 A; BI/DI=1-142 # PDB 4V6K EM; 8.25 A; AJ=1-142 # PDB 4V6L EM; 13.20 A; BJ=1-142 # PDB 4V6M EM; 7.10 A; BI=2-142 # PDB 4V6N EM; 12.10 A; AK=2-142 # PDB 4V6O EM; 14.70 A; BK=2-142 # PDB 4V6P EM; 13.50 A; BK=2-142 # PDB 4V6Q EM; 11.50 A; BK=2-142 # PDB 4V6R EM; 11.50 A; BK=2-142 # PDB 4V6S EM; 13.10 A; AK=2-142 # PDB 4V6T EM; 8.30 A; BI=2-142 # PDB 4V6V EM; 9.80 A; BK=2-142 # PDB 4V6Y EM; 12.00 A; BI=1-142 # PDB 4V6Z EM; 12.00 A; BI=1-142 # PDB 4V70 EM; 17.00 A; BI=1-142 # PDB 4V71 EM; 20.00 A; BI=1-142 # PDB 4V72 EM; 13.00 A; BI=1-142 # PDB 4V73 EM; 15.00 A; BI=1-142 # PDB 4V74 EM; 17.00 A; BI=1-142 # PDB 4V75 EM; 12.00 A; BI=1-142 # PDB 4V76 EM; 17.00 A; BI=1-142 # PDB 4V77 EM; 17.00 A; BI=1-142 # PDB 4V78 EM; 20.00 A; BI=1-142 # PDB 4V79 EM; 15.00 A; BI=1-142 # PDB 4V7A EM; 9.00 A; BI=1-142 # PDB 4V7B EM; 6.80 A; BI=1-142 # PDB 4V7C EM; 7.60 A; BK=2-142 # PDB 4V7D EM; 7.60 A; AK=2-142 # PDB 4V7I EM; 9.60 A; AI=1-142 # PDB 4V7S X-ray; 3.25 A; BI/DI=2-142 # PDB 4V7T X-ray; 3.19 A; BI/DI=2-142 # PDB 4V7U X-ray; 3.10 A; BI/DI=2-142 # PDB 4V7V X-ray; 3.29 A; BI/DI=2-142 # PDB 4V85 X-ray; 3.20 A; I=1-142 # PDB 4V89 X-ray; 3.70 A; BI=1-142 # PDB 4V9C X-ray; 3.30 A; BI/DI=1-142 # PDB 4V9D X-ray; 3.00 A; CI/DI=2-142 # PDB 4V9O X-ray; 2.90 A; AI/CI/EI/GI=1-142 # PDB 4V9P X-ray; 2.90 A; AI/CI/EI/GI=1-142 # PDB 4WF1 X-ray; 3.09 A; BI/DI=2-142 # PDB 4WOI X-ray; 3.00 A; BI/CI=1-142 # PDB 4WWW X-ray; 3.10 A; RI/YI=2-142 # PDB 4YBB X-ray; 2.10 A; CJ/DJ=8-141 # PDB 5ADY EM; 4.50 A; I=1-142 # PDB 5AFI EM; 2.90 A; I=1-142 # PDB 5AKA EM; 5.70 A; I=2-142 # PDB 5GAD EM; 3.70 A; J=1-142 # PDB 5GAE EM; 3.33 A; J=1-142 # PDB 5GAF EM; 4.30 A; J=8-141 # PDB 5GAG EM; 3.80 A; J=1-142 # PDB 5GAH EM; 3.80 A; J=1-142 # PDB 5IQR EM; 3.00 A; I=1-142 # PDB 5IT8 X-ray; 3.12 A; CJ/DJ=8-141 # PDB 5J5B X-ray; 2.80 A; CJ/DJ=8-141 # PDB 5J7L X-ray; 3.00 A; CJ/DJ=8-141 # PDB 5J88 X-ray; 3.32 A; CJ/DJ=8-142 # PDB 5J8A X-ray; 3.10 A; CJ/DJ=8-142 # PDB 5J91 X-ray; 2.96 A; CJ/DJ=8-141 # PDB 5JC9 X-ray; 3.03 A; CJ/DJ=8-141 # PDB 5JTE EM; 3.60 A; BI=1-142 # PDB 5JU8 EM; 3.60 A; BI=1-142 # PDB 5KCR EM; 3.60 A; 1K=1-142 # PDB 5KCS EM; 3.90 A; 1K=1-142 # PDB 5KPS EM; 3.90 A; I=1-142 # PDB 5KPV EM; 4.10 A; H=1-142 # PDB 5KPW EM; 3.90 A; H=1-142 # PDB 5KPX EM; 3.90 A; H=1-142 # PDB 5L3P EM; 3.70 A; K=1-142 # PIR S12572 R5EC11 # PROSITE PS00359 RIBOSOMAL_L11 # Pfam PF00298 Ribosomal_L11 # Pfam PF03946 Ribosomal_L11_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 50S ribosomal protein L11 {ECO:0000255|HAMAP-Rule MF_00736} # RefSeq NP_418410 NC_000913.3 # RefSeq WP_001085926 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein L11P family. {ECO:0000255|HAMAP-Rule MF_00736}. # SMART SM00649 RL11 # SUBUNIT Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which 2 L12 dimers bind in a sequential fashion forming a pentameric L10(L12)2(L12)2 complex. {ECO:0000269|PubMed 15923259}. # SUPFAM SSF46906 SSF46906 # SUPFAM SSF54747 SSF54747 # TIGRFAMs TIGR01632 L11_bact # eggNOG COG0080 LUCA BLAST swissprot:RL11_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RL11_ECOLI BioCyc ECOL316407:JW3946-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3946-MONOMER BioCyc EcoCyc:EG10872-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10872-MONOMER BioCyc MetaCyc:EG10872-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10872-MONOMER COG COG0080 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0080 DIP DIP-35882N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35882N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1006/jmbi.2000.3635 http://dx.doi.org/10.1006/jmbi.2000.3635 DOI 10.1016/S0092-8674(03)00427-6 http://dx.doi.org/10.1016/S0092-8674(03)00427-6 DOI 10.1016/j.celrep.2014.09.011 http://dx.doi.org/10.1016/j.celrep.2014.09.011 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nchembio.495 http://dx.doi.org/10.1038/nchembio.495 DOI 10.1073/pnas.0502193102 http://dx.doi.org/10.1073/pnas.0502193102 DOI 10.1073/pnas.76.4.1697 http://dx.doi.org/10.1073/pnas.76.4.1697 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1111/j.1432-1033.1980.tb04995.x http://dx.doi.org/10.1111/j.1432-1033.1980.tb04995.x DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pbio.1001866 http://dx.doi.org/10.1371/journal.pbio.1001866 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M30610 http://www.ebi.ac.uk/ena/data/view/M30610 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00339 http://www.ebi.ac.uk/ena/data/view/V00339 EchoBASE EB0865 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0865 EcoGene EG10872 http://www.ecogene.org/geneInfo.php?eg_id=EG10872 EnsemblBacteria AAC76957 http://www.ensemblgenomes.org/id/AAC76957 EnsemblBacteria AAC76957 http://www.ensemblgenomes.org/id/AAC76957 EnsemblBacteria BAE77337 http://www.ensemblgenomes.org/id/BAE77337 EnsemblBacteria BAE77337 http://www.ensemblgenomes.org/id/BAE77337 EnsemblBacteria BAE77337 http://www.ensemblgenomes.org/id/BAE77337 EnsemblBacteria b3983 http://www.ensemblgenomes.org/id/b3983 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0022625 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022625 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GO_function GO:0070180 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070180 GO_process GO:0000027 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000027 GO_process GO:0006415 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006415 GO_process GO:0015968 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015968 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0022618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022618 Gene3D 1.10.10.250 http://www.cathdb.info/version/latest/superfamily/1.10.10.250 Gene3D 3.30.1550.10 http://www.cathdb.info/version/latest/superfamily/3.30.1550.10 GeneID 948484 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948484 HAMAP MF_00736 http://hamap.expasy.org/unirule/MF_00736 HOGENOM HOG000082123 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000082123&db=HOGENOM6 InParanoid P0A7J7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7J7 IntAct P0A7J7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7J7* InterPro IPR000911 http://www.ebi.ac.uk/interpro/entry/IPR000911 InterPro IPR006519 http://www.ebi.ac.uk/interpro/entry/IPR006519 InterPro IPR020783 http://www.ebi.ac.uk/interpro/entry/IPR020783 InterPro IPR020784 http://www.ebi.ac.uk/interpro/entry/IPR020784 InterPro IPR020785 http://www.ebi.ac.uk/interpro/entry/IPR020785 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW3946 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3946 KEGG_Gene eco:b3983 http://www.genome.jp/dbget-bin/www_bget?eco:b3983 KEGG_Orthology KO:K02867 http://www.genome.jp/dbget-bin/www_bget?KO:K02867 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 MINT MINT-1232893 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1232893 OMA CKQFNAK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CKQFNAK PANTHER PTHR11661 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11661 PDB 1EG0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1EG0 PDB 1MJ1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1MJ1 PDB 1ML5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ML5 PDB 2J28 http://www.ebi.ac.uk/pdbe-srv/view/entry/2J28 PDB 2RDO http://www.ebi.ac.uk/pdbe-srv/view/entry/2RDO PDB 3DEG http://www.ebi.ac.uk/pdbe-srv/view/entry/3DEG PDB 3EP2 http://www.ebi.ac.uk/pdbe-srv/view/entry/3EP2 PDB 3EQ3 http://www.ebi.ac.uk/pdbe-srv/view/entry/3EQ3 PDB 3EQ4 http://www.ebi.ac.uk/pdbe-srv/view/entry/3EQ4 PDB 3J0D http://www.ebi.ac.uk/pdbe-srv/view/entry/3J0D PDB 3J5L http://www.ebi.ac.uk/pdbe-srv/view/entry/3J5L PDB 3J7Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J7Z PDB 3J8G http://www.ebi.ac.uk/pdbe-srv/view/entry/3J8G PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 487D http://www.ebi.ac.uk/pdbe-srv/view/entry/487D PDB 4CSU http://www.ebi.ac.uk/pdbe-srv/view/entry/4CSU PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4UY8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4UY8 PDB 4V47 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V47 PDB 4V48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V48 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5ADY http://www.ebi.ac.uk/pdbe-srv/view/entry/5ADY PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5AKA http://www.ebi.ac.uk/pdbe-srv/view/entry/5AKA PDB 5GAD http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAD PDB 5GAE http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAE PDB 5GAF http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAF PDB 5GAG http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAG PDB 5GAH http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAH PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 1EG0 http://www.ebi.ac.uk/pdbsum/1EG0 PDBsum 1MJ1 http://www.ebi.ac.uk/pdbsum/1MJ1 PDBsum 1ML5 http://www.ebi.ac.uk/pdbsum/1ML5 PDBsum 2J28 http://www.ebi.ac.uk/pdbsum/2J28 PDBsum 2RDO http://www.ebi.ac.uk/pdbsum/2RDO PDBsum 3DEG http://www.ebi.ac.uk/pdbsum/3DEG PDBsum 3EP2 http://www.ebi.ac.uk/pdbsum/3EP2 PDBsum 3EQ3 http://www.ebi.ac.uk/pdbsum/3EQ3 PDBsum 3EQ4 http://www.ebi.ac.uk/pdbsum/3EQ4 PDBsum 3J0D http://www.ebi.ac.uk/pdbsum/3J0D PDBsum 3J5L http://www.ebi.ac.uk/pdbsum/3J5L PDBsum 3J7Z http://www.ebi.ac.uk/pdbsum/3J7Z PDBsum 3J8G http://www.ebi.ac.uk/pdbsum/3J8G PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 487D http://www.ebi.ac.uk/pdbsum/487D PDBsum 4CSU http://www.ebi.ac.uk/pdbsum/4CSU PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4UY8 http://www.ebi.ac.uk/pdbsum/4UY8 PDBsum 4V47 http://www.ebi.ac.uk/pdbsum/4V47 PDBsum 4V48 http://www.ebi.ac.uk/pdbsum/4V48 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5ADY http://www.ebi.ac.uk/pdbsum/5ADY PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5AKA http://www.ebi.ac.uk/pdbsum/5AKA PDBsum 5GAD http://www.ebi.ac.uk/pdbsum/5GAD PDBsum 5GAE http://www.ebi.ac.uk/pdbsum/5GAE PDBsum 5GAF http://www.ebi.ac.uk/pdbsum/5GAF PDBsum 5GAG http://www.ebi.ac.uk/pdbsum/5GAG PDBsum 5GAH http://www.ebi.ac.uk/pdbsum/5GAH PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PROSITE PS00359 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00359 PSORT swissprot:RL11_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RL11_ECOLI PSORT-B swissprot:RL11_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RL11_ECOLI PSORT2 swissprot:RL11_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RL11_ECOLI Pfam PF00298 http://pfam.xfam.org/family/PF00298 Pfam PF03946 http://pfam.xfam.org/family/PF03946 Phobius swissprot:RL11_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RL11_ECOLI PhylomeDB P0A7J7 http://phylomedb.org/?seqid=P0A7J7 ProteinModelPortal P0A7J7 http://www.proteinmodelportal.org/query/uniprot/P0A7J7 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 10756104 http://www.ncbi.nlm.nih.gov/pubmed/10756104 PubMed 12809609 http://www.ncbi.nlm.nih.gov/pubmed/12809609 PubMed 15923259 http://www.ncbi.nlm.nih.gov/pubmed/15923259 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21151122 http://www.ncbi.nlm.nih.gov/pubmed/21151122 PubMed 2137819 http://www.ncbi.nlm.nih.gov/pubmed/2137819 PubMed 2483975 http://www.ncbi.nlm.nih.gov/pubmed/2483975 PubMed 24844575 http://www.ncbi.nlm.nih.gov/pubmed/24844575 PubMed 25310980 http://www.ncbi.nlm.nih.gov/pubmed/25310980 PubMed 377281 http://www.ncbi.nlm.nih.gov/pubmed/377281 PubMed 7004866 http://www.ncbi.nlm.nih.gov/pubmed/7004866 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_418410 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418410 RefSeq WP_001085926 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001085926 SMART SM00649 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00649 SMR P0A7J7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7J7 STRING 511145.b3983 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3983&targetmode=cogs STRING COG0080 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0080&targetmode=cogs SUPFAM SSF46906 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46906 SUPFAM SSF54747 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54747 TIGRFAMs TIGR01632 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01632 UniProtKB RL11_ECOLI http://www.uniprot.org/uniprot/RL11_ECOLI UniProtKB-AC P0A7J7 http://www.uniprot.org/uniprot/P0A7J7 charge swissprot:RL11_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RL11_ECOLI eggNOG COG0080 http://eggnogapi.embl.de/nog_data/html/tree/COG0080 epestfind swissprot:RL11_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RL11_ECOLI garnier swissprot:RL11_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RL11_ECOLI helixturnhelix swissprot:RL11_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RL11_ECOLI hmoment swissprot:RL11_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RL11_ECOLI iep swissprot:RL11_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RL11_ECOLI inforesidue swissprot:RL11_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RL11_ECOLI octanol swissprot:RL11_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RL11_ECOLI pepcoil swissprot:RL11_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RL11_ECOLI pepdigest swissprot:RL11_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RL11_ECOLI pepinfo swissprot:RL11_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RL11_ECOLI pepnet swissprot:RL11_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RL11_ECOLI pepstats swissprot:RL11_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RL11_ECOLI pepwheel swissprot:RL11_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RL11_ECOLI pepwindow swissprot:RL11_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RL11_ECOLI sigcleave swissprot:RL11_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RL11_ECOLI ## Database ID URL or Descriptions # AltName Fructose-like phosphotransferase enzyme IIA component {ECO:0000303|PubMed 11361063} # AltName Phosphotransferase system enzyme I {ECO:0000303|PubMed 11361063} # AltName Phosphotransferase system enzyme I {ECO:0000303|PubMed 11361063} # AltName Triphosphoryl transfer protein 1 {ECO:0000305|PubMed 11361063} # BioGrid 4261077 13 # CATALYTIC ACTIVITY Phosphoenolpyruvate + protein L-histidine = pyruvate + protein N(pi)-phospho-L-histidine. {ECO:0000250|UniProtKB P08839}. # CATALYTIC ACTIVITY [Protein]-N(pi)-phospho-L-histidine + D- fructose(Side 1) = [protein]-L-histidine + D-fructose 1- phosphate(Side 2). {ECO:0000250|UniProtKB P20966}. # CDD cd00367 PTS-HPr_like # COFACTOR PTFX1_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250|UniProtKB P08839}; # DOMAIN PTFX1_ECOLI In contrast to classical PTS systems, the fructose-like PTS has no requirement for HPr and Enzyme I; FryA combines a IIA domain with an Enzyme I and a HPr domains. {ECO 0000305}. # DOMAIN PTFX1_ECOLI The PTS EIIA type-2 domain is phosphorylated by phospho- HPr on a histidyl residue. Then, it transfers the phosphoryl group to the PTS EIIB type-2 domain. {ECO 0000255|PROSITE- ProRule PRU00417}. # EcoGene EG14151 fryA # FUNCTION PTFX1_ECOLI Multifunctional protein that includes general (non sugar-specific) and sugar-specific components of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FryABC PTS system is involved in fructose transport. {ECO 0000305|PubMed 11361063}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:InterPro. # GO_function GO:0008965 phosphoenolpyruvate-protein phosphotransferase activity; IEA:UniProtKB-EC. # GO_function GO:0008982 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:InterPro. # GO_function GO:0016301 kinase activity; IEA:UniProtKB-KW. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # Gene3D 1.10.274.10 -; 1. # Gene3D 3.20.20.60 -; 1. # Gene3D 3.30.1340.10 -; 1. # Gene3D 3.40.930.10 -; 1. # Gene3D 3.50.30.10 -; 1. # InterPro IPR000032 HPr-like # InterPro IPR000121 PEP_util_C # InterPro IPR002178 PTS_EIIA_type-2_dom # InterPro IPR004715 PTS_IIA_fruc # InterPro IPR006318 PTS_EI-like # InterPro IPR008279 PEP-util_enz_mobile_dom # InterPro IPR008731 PTS_EIN # InterPro IPR015813 Pyrv/PenolPyrv_Kinase-like_dom # InterPro IPR016152 PTrfase/Anion_transptr # InterPro IPR023151 PEP_util_CS # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00306 PTS system, fructose-specific II-like component # KEGG_Brite ko02000 Transporters # Organism PTFX1_ECOLI Escherichia coli (strain K12) # PATRIC 32120145 VBIEscCol129921_2481 # PIR D65012 D65012 # PROSITE PS00742 PEP_ENZYMES_2 # PROSITE PS51094 PTS_EIIA_TYPE_2 # PROSITE PS51350 PTS_HPR_DOM # Pfam PF00359 PTS_EIIA_2 # Pfam PF00381 PTS-HPr # Pfam PF00391 PEP-utilizers # Pfam PF02896 PEP-utilizers_C # Pfam PF05524 PEP-utilisers_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Multiphosphoryl transfer protein 1 {ECO:0000305|PubMed 11361063} # RecName PTS system fructose-like EIIA component {ECO:0000303|PubMed 11361063} # RecName Phosphocarrier protein HPr {ECO:0000303|PubMed 11361063} # RecName Phosphoenolpyruvate-protein phosphotransferase {ECO:0000303|PubMed 11361063} # RefSeq NP_416884 NC_000913.3 # RefSeq WP_000955906 NZ_LN832404.1 # SIMILARITY Belongs to the PEP-utilizing enzyme family. {ECO 0000305}. # SIMILARITY Contains 1 HPr domain. {ECO:0000255|PROSITE- ProRule PRU00681}. # SIMILARITY Contains 1 PTS EIIA type-2 domain. {ECO:0000255|PROSITE-ProRule PRU00417}. # SUBCELLULAR LOCATION PTFX1_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF47831 SSF47831 # SUPFAM SSF51621 SSF51621 # SUPFAM SSF52009 SSF52009 # SUPFAM SSF55594 SSF55594 # SUPFAM SSF55804 SSF55804 # TCDB 4.A.2.1.11 the pts fructose-mannitol (fru) family # TIGRFAMs TIGR00848 fruA # TIGRFAMs TIGR01417 PTS_I_fam # eggNOG COG1080 LUCA # eggNOG COG1925 LUCA # eggNOG ENOG4105BZ3 Bacteria BLAST swissprot:PTFX1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTFX1_ECOLI BioCyc ECOL316407:JW2380-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2380-MONOMER BioCyc EcoCyc:G7246-MONOMER http://biocyc.org/getid?id=EcoCyc:G7246-MONOMER COG COG1762 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1762 DIP DIP-12817N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12817N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.202 {ECO:0000250|UniProtKB:P20966} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.202 {ECO:0000250|UniProtKB:P20966} EC_number EC:2.7.3.9 {ECO:0000250|UniProtKB:P08839} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.3.9 {ECO:0000250|UniProtKB:P08839} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.202 {ECO:0000250|UniProtKB:P20966} http://enzyme.expasy.org/EC/2.7.1.202 {ECO:0000250|UniProtKB:P20966} ENZYME 2.7.3.9 {ECO:0000250|UniProtKB:P08839} http://enzyme.expasy.org/EC/2.7.3.9 {ECO:0000250|UniProtKB:P08839} EchoBASE EB3903 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3903 EcoGene EG14151 http://www.ecogene.org/geneInfo.php?eg_id=EG14151 EnsemblBacteria AAC75442 http://www.ensemblgenomes.org/id/AAC75442 EnsemblBacteria AAC75442 http://www.ensemblgenomes.org/id/AAC75442 EnsemblBacteria BAA16253 http://www.ensemblgenomes.org/id/BAA16253 EnsemblBacteria BAA16253 http://www.ensemblgenomes.org/id/BAA16253 EnsemblBacteria BAA16253 http://www.ensemblgenomes.org/id/BAA16253 EnsemblBacteria b2383 http://www.ensemblgenomes.org/id/b2383 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008965 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008965 GO_function GO:0008982 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008982 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 1.10.274.10 http://www.cathdb.info/version/latest/superfamily/1.10.274.10 Gene3D 3.20.20.60 http://www.cathdb.info/version/latest/superfamily/3.20.20.60 Gene3D 3.30.1340.10 http://www.cathdb.info/version/latest/superfamily/3.30.1340.10 Gene3D 3.40.930.10 http://www.cathdb.info/version/latest/superfamily/3.40.930.10 Gene3D 3.50.30.10 http://www.cathdb.info/version/latest/superfamily/3.50.30.10 GeneID 946852 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946852 HOGENOM HOG000122933 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122933&db=HOGENOM6 InParanoid P77439 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77439 IntAct P77439 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77439* IntEnz 2.7.1.202 {ECO:0000250|UniProtKB:P20966} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.202 {ECO:0000250|UniProtKB:P20966} IntEnz 2.7.3.9 {ECO:0000250|UniProtKB:P08839} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.3.9 {ECO:0000250|UniProtKB:P08839} InterPro IPR000032 http://www.ebi.ac.uk/interpro/entry/IPR000032 InterPro IPR000121 http://www.ebi.ac.uk/interpro/entry/IPR000121 InterPro IPR002178 http://www.ebi.ac.uk/interpro/entry/IPR002178 InterPro IPR004715 http://www.ebi.ac.uk/interpro/entry/IPR004715 InterPro IPR006318 http://www.ebi.ac.uk/interpro/entry/IPR006318 InterPro IPR008279 http://www.ebi.ac.uk/interpro/entry/IPR008279 InterPro IPR008731 http://www.ebi.ac.uk/interpro/entry/IPR008731 InterPro IPR015813 http://www.ebi.ac.uk/interpro/entry/IPR015813 InterPro IPR016152 http://www.ebi.ac.uk/interpro/entry/IPR016152 InterPro IPR023151 http://www.ebi.ac.uk/interpro/entry/IPR023151 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2380 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2380 KEGG_Gene eco:b2383 http://www.genome.jp/dbget-bin/www_bget?eco:b2383 KEGG_Orthology KO:K11201 http://www.genome.jp/dbget-bin/www_bget?KO:K11201 OMA INHVKVF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=INHVKVF PROSITE PS00742 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00742 PROSITE PS51094 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51094 PROSITE PS51350 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51350 PSORT swissprot:PTFX1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTFX1_ECOLI PSORT-B swissprot:PTFX1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTFX1_ECOLI PSORT2 swissprot:PTFX1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTFX1_ECOLI Pfam PF00359 http://pfam.xfam.org/family/PF00359 Pfam PF00381 http://pfam.xfam.org/family/PF00381 Pfam PF00391 http://pfam.xfam.org/family/PF00391 Pfam PF02896 http://pfam.xfam.org/family/PF02896 Pfam PF05524 http://pfam.xfam.org/family/PF05524 Phobius swissprot:PTFX1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTFX1_ECOLI PhylomeDB P77439 http://phylomedb.org/?seqid=P77439 ProteinModelPortal P77439 http://www.proteinmodelportal.org/query/uniprot/P77439 PubMed 11361063 http://www.ncbi.nlm.nih.gov/pubmed/11361063 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416884 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416884 RefSeq WP_000955906 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000955906 SMR P77439 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77439 STRING 511145.b2383 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2383&targetmode=cogs STRING COG1762 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1762&targetmode=cogs SUPFAM SSF47831 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47831 SUPFAM SSF51621 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51621 SUPFAM SSF52009 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52009 SUPFAM SSF55594 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55594 SUPFAM SSF55804 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55804 TCDB 4.A.2.1.11 http://www.tcdb.org/search/result.php?tc=4.A.2.1.11 TIGRFAMs TIGR00848 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00848 TIGRFAMs TIGR01417 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01417 UniProtKB PTFX1_ECOLI http://www.uniprot.org/uniprot/PTFX1_ECOLI UniProtKB-AC P77439 http://www.uniprot.org/uniprot/P77439 charge swissprot:PTFX1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTFX1_ECOLI eggNOG COG1080 http://eggnogapi.embl.de/nog_data/html/tree/COG1080 eggNOG COG1925 http://eggnogapi.embl.de/nog_data/html/tree/COG1925 eggNOG ENOG4105BZ3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZ3 epestfind swissprot:PTFX1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTFX1_ECOLI garnier swissprot:PTFX1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTFX1_ECOLI helixturnhelix swissprot:PTFX1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTFX1_ECOLI hmoment swissprot:PTFX1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTFX1_ECOLI iep swissprot:PTFX1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTFX1_ECOLI inforesidue swissprot:PTFX1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTFX1_ECOLI octanol swissprot:PTFX1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTFX1_ECOLI pepcoil swissprot:PTFX1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTFX1_ECOLI pepdigest swissprot:PTFX1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTFX1_ECOLI pepinfo swissprot:PTFX1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTFX1_ECOLI pepnet swissprot:PTFX1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTFX1_ECOLI pepstats swissprot:PTFX1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTFX1_ECOLI pepwheel swissprot:PTFX1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTFX1_ECOLI pepwindow swissprot:PTFX1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTFX1_ECOLI sigcleave swissprot:PTFX1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTFX1_ECOLI ## Database ID URL or Descriptions # BioGrid 4261782 65 # EcoGene EG12005 yehS # InterPro IPR009921 DUF1456 # Organism YEHS_ECOLI Escherichia coli (strain K12) # PATRIC 32119585 VBIEscCol129921_2203 # PIR C64980 C64980 # Pfam PF07308 DUF1456; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEHS_ECOLI Uncharacterized protein YehS # RefSeq NP_416628 NC_000913.3 # RefSeq WP_000950409 NZ_LN832404.1 # eggNOG COG4807 LUCA # eggNOG ENOG4108W15 Bacteria BLAST swissprot:YEHS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEHS_ECOLI BioCyc ECOL316407:JW2112-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2112-MONOMER BioCyc EcoCyc:EG12005-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12005-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1943 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1943 EcoGene EG12005 http://www.ecogene.org/geneInfo.php?eg_id=EG12005 EnsemblBacteria AAC75185 http://www.ensemblgenomes.org/id/AAC75185 EnsemblBacteria AAC75185 http://www.ensemblgenomes.org/id/AAC75185 EnsemblBacteria BAE76600 http://www.ensemblgenomes.org/id/BAE76600 EnsemblBacteria BAE76600 http://www.ensemblgenomes.org/id/BAE76600 EnsemblBacteria BAE76600 http://www.ensemblgenomes.org/id/BAE76600 EnsemblBacteria b2124 http://www.ensemblgenomes.org/id/b2124 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 949026 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949026 HOGENOM HOG000272318 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000272318&db=HOGENOM6 InParanoid P33355 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33355 InterPro IPR009921 http://www.ebi.ac.uk/interpro/entry/IPR009921 KEGG_Gene ecj:JW2112 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2112 KEGG_Gene eco:b2124 http://www.genome.jp/dbget-bin/www_bget?eco:b2124 OMA KEDDMHA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KEDDMHA PSORT swissprot:YEHS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEHS_ECOLI PSORT-B swissprot:YEHS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEHS_ECOLI PSORT2 swissprot:YEHS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEHS_ECOLI Pfam PF07308 http://pfam.xfam.org/family/PF07308 Phobius swissprot:YEHS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEHS_ECOLI PhylomeDB P33355 http://phylomedb.org/?seqid=P33355 ProteinModelPortal P33355 http://www.proteinmodelportal.org/query/uniprot/P33355 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416628 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416628 RefSeq WP_000950409 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000950409 SMR P33355 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33355 STRING 511145.b2124 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2124&targetmode=cogs UniProtKB YEHS_ECOLI http://www.uniprot.org/uniprot/YEHS_ECOLI UniProtKB-AC P33355 http://www.uniprot.org/uniprot/P33355 charge swissprot:YEHS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEHS_ECOLI eggNOG COG4807 http://eggnogapi.embl.de/nog_data/html/tree/COG4807 eggNOG ENOG4108W15 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108W15 epestfind swissprot:YEHS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEHS_ECOLI garnier swissprot:YEHS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEHS_ECOLI helixturnhelix swissprot:YEHS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEHS_ECOLI hmoment swissprot:YEHS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEHS_ECOLI iep swissprot:YEHS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEHS_ECOLI inforesidue swissprot:YEHS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEHS_ECOLI octanol swissprot:YEHS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEHS_ECOLI pepcoil swissprot:YEHS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEHS_ECOLI pepdigest swissprot:YEHS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEHS_ECOLI pepinfo swissprot:YEHS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEHS_ECOLI pepnet swissprot:YEHS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEHS_ECOLI pepstats swissprot:YEHS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEHS_ECOLI pepwheel swissprot:YEHS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEHS_ECOLI pepwindow swissprot:YEHS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEHS_ECOLI sigcleave swissprot:YEHS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEHS_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES XANP_ECOLI Kinetic parameters KM=2.9 uM for xanthine {ECO 0000269|PubMed 16096267}; Vmax=0.59 nmol/min/mg enzyme {ECO 0000269|PubMed 16096267}; # BioGrid 4262570 7 # ENZYME REGULATION Inhibited by CCCP and N-ethylmaleimide. {ECO:0000269|PubMed 16096267}. # EcoGene EG11194 xanP # FUNCTION XANP_ECOLI Specific, proton motive force-dependent high-affinity transporter for xanthine. {ECO 0000269|PubMed 16096267}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_function GO:0042907 xanthine transmembrane transporter activity; IDA:EcoCyc. # GO_process GO:0042906 xanthine transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR006042 Xan_ur_permease # InterPro IPR006043 Xant/urac/vitC # KEGG_Brite ko02000 Transporters # Organism XANP_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11119 PTHR11119 # PATRIC 32122795 VBIEscCol129921_3774 # PIR H65166 H65166 # PROSITE PS01116 XANTH_URACIL_PERMASE # Pfam PF00860 Xan_ur_permease # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName XANP_ECOLI Xanthine permease XanP # RefSeq NP_418111 NC_000913.3 # RefSeq WP_001295238 NZ_LN832404.1 # SIMILARITY Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION XANP_ECOLI Cell inner membrane {ECO 0000269|PubMed 16096267}; Multi-pass membrane protein {ECO 0000269|PubMed 16096267}. # TCDB 2.A.40.4:the nucleobase/ascorbate transporter (nat) or nucleobase cation symporter-2 (ncs2) family # TIGRFAMs TIGR00801 ncs2 # eggNOG COG2233 LUCA # eggNOG ENOG4105C2W Bacteria BLAST swissprot:XANP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:XANP_ECOLI BioCyc ECOL316407:JW3629-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3629-MONOMER BioCyc EcoCyc:YICE-MONOMER http://biocyc.org/getid?id=EcoCyc:YICE-MONOMER BioCyc MetaCyc:YICE-MONOMER http://biocyc.org/getid?id=MetaCyc:YICE-MONOMER COG COG2233 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2233 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1007/BF00261677 http://dx.doi.org/10.1007/BF00261677 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1080/09687860500092927 http://dx.doi.org/10.1080/09687860500092927 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X17499 http://www.ebi.ac.uk/ena/data/view/X17499 EchoBASE EB1180 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1180 EcoGene EG11194 http://www.ecogene.org/geneInfo.php?eg_id=EG11194 EnsemblBacteria AAC76678 http://www.ensemblgenomes.org/id/AAC76678 EnsemblBacteria AAC76678 http://www.ensemblgenomes.org/id/AAC76678 EnsemblBacteria BAE77639 http://www.ensemblgenomes.org/id/BAE77639 EnsemblBacteria BAE77639 http://www.ensemblgenomes.org/id/BAE77639 EnsemblBacteria BAE77639 http://www.ensemblgenomes.org/id/BAE77639 EnsemblBacteria b3654 http://www.ensemblgenomes.org/id/b3654 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0042907 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042907 GO_process GO:0042906 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042906 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948172 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948172 HOGENOM HOG000038198 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000038198&db=HOGENOM6 InParanoid P0AGM9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGM9 InterPro IPR006042 http://www.ebi.ac.uk/interpro/entry/IPR006042 InterPro IPR006043 http://www.ebi.ac.uk/interpro/entry/IPR006043 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3629 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3629 KEGG_Gene eco:b3654 http://www.genome.jp/dbget-bin/www_bget?eco:b3654 KEGG_Orthology KO:K16345 http://www.genome.jp/dbget-bin/www_bget?KO:K16345 OMA FSWALFI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FSWALFI PANTHER PTHR11119 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11119 PROSITE PS01116 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01116 PSORT swissprot:XANP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:XANP_ECOLI PSORT-B swissprot:XANP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:XANP_ECOLI PSORT2 swissprot:XANP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:XANP_ECOLI Pfam PF00860 http://pfam.xfam.org/family/PF00860 Phobius swissprot:XANP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:XANP_ECOLI PhylomeDB P0AGM9 http://phylomedb.org/?seqid=P0AGM9 ProteinModelPortal P0AGM9 http://www.proteinmodelportal.org/query/uniprot/P0AGM9 PubMed 16096267 http://www.ncbi.nlm.nih.gov/pubmed/16096267 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2017136 http://www.ncbi.nlm.nih.gov/pubmed/2017136 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418111 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418111 RefSeq WP_001295238 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295238 STRING 511145.b3654 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3654&targetmode=cogs STRING COG2233 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2233&targetmode=cogs TCDB 2.A.40.4 http://www.tcdb.org/search/result.php?tc=2.A.40.4 TIGRFAMs TIGR00801 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00801 UniProtKB XANP_ECOLI http://www.uniprot.org/uniprot/XANP_ECOLI UniProtKB-AC P0AGM9 http://www.uniprot.org/uniprot/P0AGM9 charge swissprot:XANP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:XANP_ECOLI eggNOG COG2233 http://eggnogapi.embl.de/nog_data/html/tree/COG2233 eggNOG ENOG4105C2W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C2W epestfind swissprot:XANP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:XANP_ECOLI garnier swissprot:XANP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:XANP_ECOLI helixturnhelix swissprot:XANP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:XANP_ECOLI hmoment swissprot:XANP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:XANP_ECOLI iep swissprot:XANP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:XANP_ECOLI inforesidue swissprot:XANP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:XANP_ECOLI octanol swissprot:XANP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:XANP_ECOLI pepcoil swissprot:XANP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:XANP_ECOLI pepdigest swissprot:XANP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:XANP_ECOLI pepinfo swissprot:XANP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:XANP_ECOLI pepnet swissprot:XANP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:XANP_ECOLI pepstats swissprot:XANP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:XANP_ECOLI pepwheel swissprot:XANP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:XANP_ECOLI pepwindow swissprot:XANP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:XANP_ECOLI sigcleave swissprot:XANP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:XANP_ECOLI ## Database ID URL or Descriptions # EcoGene EG10917 rpsR # FUNCTION RS18_ECOLI Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0022627 cytosolic small ribosomal subunit; IDA:EcoCyc. # GO_function GO:0003735 structural constituent of ribosome; IBA:GO_Central. # GO_function GO:0048027 mRNA 5'-UTR binding; IDA:EcoCyc. # GO_function GO:0070181 small ribosomal subunit rRNA binding; IDA:EcoCyc. # GO_process GO:0006412 translation; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003729 mRNA binding # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_function GO:0019843 rRNA binding # GOslim_process GO:0006412 translation # Gene3D 4.10.640.10 -; 1. # HAMAP MF_00270 Ribosomal_S18 # INTERACTION RS18_ECOLI P02358 rpsF; NbExp=4; IntAct=EBI-548844, EBI-543068; # IntAct P0A7T7 26 # InterPro IPR001648 Ribosomal_S18 # InterPro IPR018275 Ribosomal_S18_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=8897.0; Method=MALDI; Range=2-75; Evidence={ECO:0000269|PubMed 10094780}; # Organism RS18_ECOLI Escherichia coli (strain K12) # PATRIC 32123979 VBIEscCol129921_4334 # PDB 1M5G Model; -; R=5-75 # PDB 2YKR EM; 9.80 A; R=20-74 # PDB 3J9Y EM; 3.90 A; r=1-75 # PDB 3J9Z EM; 3.60 A; SR=2-75 # PDB 3JA1 EM; 3.60 A; SR=2-75 # PDB 3JBU EM; 3.64 A; R=1-75 # PDB 3JBV EM; 3.32 A; R=1-75 # PDB 3JCD EM; 3.70 A; r=1-75 # PDB 3JCE EM; 3.20 A; r=1-75 # PDB 3JCJ EM; 3.70 A; 1=1-75 # PDB 3JCN EM; 4.60 A; u=1-75 # PDB 4A2I EM; 16.50 A; R=20-74 # PDB 4ADV EM; 13.50 A; R=2-75 # PDB 4U1U X-ray; 2.95 A; AR/CR=20-74 # PDB 4U1V X-ray; 3.00 A; AR/CR=20-74 # PDB 4U20 X-ray; 2.90 A; AR/CR=20-74 # PDB 4U24 X-ray; 2.90 A; AR/CR=20-74 # PDB 4U25 X-ray; 2.90 A; AR/CR=20-74 # PDB 4U26 X-ray; 2.80 A; AR/CR=20-74 # PDB 4U27 X-ray; 2.80 A; AR/CR=20-74 # PDB 4V47 EM; 12.30 A; BR=2-75 # PDB 4V48 EM; 11.50 A; BR=2-75 # PDB 4V4H X-ray; 3.46 A; AR/CR=1-75 # PDB 4V4Q X-ray; 3.46 A; AR/CR=2-75 # PDB 4V4V EM; 15.00 A; AR=7-75 # PDB 4V4W EM; 15.00 A; AR=7-75 # PDB 4V50 X-ray; 3.22 A; AR/CR=2-75 # PDB 4V52 X-ray; 3.21 A; AR/CR=2-75 # PDB 4V53 X-ray; 3.54 A; AR/CR=2-75 # PDB 4V54 X-ray; 3.30 A; AR/CR=2-75 # PDB 4V55 X-ray; 4.00 A; AR/CR=2-75 # PDB 4V56 X-ray; 3.93 A; AR/CR=2-75 # PDB 4V57 X-ray; 3.50 A; AR/CR=2-75 # PDB 4V5B X-ray; 3.74 A; BR/DR=2-75 # PDB 4V5H EM; 5.80 A; AR=20-74 # PDB 4V5Y X-ray; 4.45 A; AR/CR=2-75 # PDB 4V64 X-ray; 3.50 A; AR/CR=2-75 # PDB 4V65 EM; 9.00 A; AK=1-75 # PDB 4V66 EM; 9.00 A; AK=1-75 # PDB 4V69 EM; 6.70 A; AR=20-74 # PDB 4V6C X-ray; 3.19 A; AR/CR=1-75 # PDB 4V6D X-ray; 3.81 A; AR/CR=1-75 # PDB 4V6E X-ray; 3.71 A; AR/CR=1-75 # PDB 4V6K EM; 8.25 A; BV=1-75 # PDB 4V6L EM; 13.20 A; AV=1-75 # PDB 4V6M EM; 7.10 A; AR=2-75 # PDB 4V6N EM; 12.10 A; BU=2-75 # PDB 4V6O EM; 14.70 A; AU=2-75 # PDB 4V6P EM; 13.50 A; AU=2-75 # PDB 4V6Q EM; 11.50 A; AU=2-75 # PDB 4V6R EM; 11.50 A; AU=2-75 # PDB 4V6S EM; 13.10 A; BT=2-75 # PDB 4V6T EM; 8.30 A; AR=20-74 # PDB 4V6V EM; 9.80 A; AR=2-75 # PDB 4V6Y EM; 12.00 A; AR=20-74 # PDB 4V6Z EM; 12.00 A; AR=20-74 # PDB 4V70 EM; 17.00 A; AR=20-74 # PDB 4V71 EM; 20.00 A; AR=20-74 # PDB 4V72 EM; 13.00 A; AR=20-74 # PDB 4V73 EM; 15.00 A; AR=20-74 # PDB 4V74 EM; 17.00 A; AR=20-74 # PDB 4V75 EM; 12.00 A; AR=20-74 # PDB 4V76 EM; 17.00 A; AR=20-74 # PDB 4V77 EM; 17.00 A; AR=20-74 # PDB 4V78 EM; 20.00 A; AR=20-74 # PDB 4V79 EM; 15.00 A; AR=20-74 # PDB 4V7A EM; 9.00 A; AR=20-74 # PDB 4V7B EM; 6.80 A; AR=1-75 # PDB 4V7C EM; 7.60 A; AR=2-75 # PDB 4V7D EM; 7.60 A; BR=2-75 # PDB 4V7I EM; 9.60 A; BR=1-75 # PDB 4V7S X-ray; 3.25 A; AR/CR=20-74 # PDB 4V7T X-ray; 3.19 A; AR/CR=20-74 # PDB 4V7U X-ray; 3.10 A; AR/CR=20-74 # PDB 4V7V X-ray; 3.29 A; AR/CR=20-74 # PDB 4V85 X-ray; 3.20 A; R=1-75 # PDB 4V89 X-ray; 3.70 A; AR=1-75 # PDB 4V9C X-ray; 3.30 A; AR/CR=1-75 # PDB 4V9D X-ray; 3.00 A; AR/BR=20-74 # PDB 4V9O X-ray; 2.90 A; BR/DR/FR/HR=1-75 # PDB 4V9P X-ray; 2.90 A; BR/DR/FR/HR=1-75 # PDB 4WF1 X-ray; 3.09 A; AR/CR=20-74 # PDB 4WOI X-ray; 3.00 A; AR/DR=1-75 # PDB 4WWW X-ray; 3.10 A; QR/XR=20-74 # PDB 4YBB X-ray; 2.10 A; AR/BR=20-74 # PDB 5AFI EM; 2.90 A; r=1-75 # PDB 5IQR EM; 3.00 A; w=1-75 # PDB 5IT8 X-ray; 3.12 A; AR/BR=20-74 # PDB 5J5B X-ray; 2.80 A; AR/BR=20-74 # PDB 5J7L X-ray; 3.00 A; AR/BR=20-74 # PDB 5J88 X-ray; 3.32 A; AR/BR=20-74 # PDB 5J8A X-ray; 3.10 A; AR/BR=20-74 # PDB 5J91 X-ray; 2.96 A; AR/BR=20-74 # PDB 5JC9 X-ray; 3.03 A; AR/BR=20-74 # PDB 5JTE EM; 3.60 A; AR=1-75 # PDB 5JU8 EM; 3.60 A; AR=1-75 # PDB 5KCR EM; 3.60 A; 1r=1-75 # PDB 5KCS EM; 3.90 A; 1r=1-75 # PDB 5KPS EM; 3.90 A; 23=1-75 # PDB 5KPV EM; 4.10 A; 22=1-75 # PDB 5KPW EM; 3.90 A; 22=1-75 # PDB 5KPX EM; 3.90 A; 22=1-75 # PDB 5L3P EM; 3.70 A; r=1-75 # PIR S56427 R3EC18 # PRINTS PR00974 RIBOSOMALS18 # PROSITE PS00057 RIBOSOMAL_S18 # Pfam PF01084 Ribosomal_S18 # ProDom PD002239 Ribosomal_S18 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RS18_ECOLI 30S ribosomal protein S18 # RefSeq NP_418623 NC_000913.3 # RefSeq WP_000135199 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein S18P family. {ECO 0000305}. # SUBUNIT RS18_ECOLI Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6. # SUPFAM SSF46911 SSF46911 # TIGRFAMs TIGR00165 S18 # eggNOG COG0238 LUCA BLAST swissprot:RS18_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RS18_ECOLI BioCyc ECOL316407:JW4160-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4160-MONOMER BioCyc EcoCyc:EG10917-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10917-MONOMER BioCyc MetaCyc:EG10917-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10917-MONOMER COG COG0238 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0238 DIP DIP-47889N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47889N DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1007/BF00330199 http://dx.doi.org/10.1007/BF00330199 DOI 10.1016/0014-5793(75)80378-4 http://dx.doi.org/10.1016/0014-5793(75)80378-4 DOI 10.1016/S0092-8674(03)00427-6 http://dx.doi.org/10.1016/S0092-8674(03)00427-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb841 http://dx.doi.org/10.1038/nsb841 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DisProt DP00146 http://www.disprot.org/protein.php?id=DP00146 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X04022 http://www.ebi.ac.uk/ena/data/view/X04022 EchoBASE EB0910 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0910 EcoGene EG10917 http://www.ecogene.org/geneInfo.php?eg_id=EG10917 EnsemblBacteria AAC77159 http://www.ensemblgenomes.org/id/AAC77159 EnsemblBacteria AAC77159 http://www.ensemblgenomes.org/id/AAC77159 EnsemblBacteria BAE78203 http://www.ensemblgenomes.org/id/BAE78203 EnsemblBacteria BAE78203 http://www.ensemblgenomes.org/id/BAE78203 EnsemblBacteria BAE78203 http://www.ensemblgenomes.org/id/BAE78203 EnsemblBacteria b4202 http://www.ensemblgenomes.org/id/b4202 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0022627 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022627 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_function GO:0048027 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048027 GO_function GO:0070181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070181 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003729 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003729 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 Gene3D 4.10.640.10 http://www.cathdb.info/version/latest/superfamily/4.10.640.10 GeneID 948721 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948721 GeneID 9735149 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9735149 HAMAP MF_00270 http://hamap.expasy.org/unirule/MF_00270 HOGENOM HOG000218466 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218466&db=HOGENOM6 InParanoid P0A7T7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7T7 IntAct P0A7T7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7T7* InterPro IPR001648 http://www.ebi.ac.uk/interpro/entry/IPR001648 InterPro IPR018275 http://www.ebi.ac.uk/interpro/entry/IPR018275 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW4160 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4160 KEGG_Gene eco:b4202 http://www.genome.jp/dbget-bin/www_bget?eco:b4202 KEGG_Orthology KO:K02963 http://www.genome.jp/dbget-bin/www_bget?KO:K02963 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 MINT MINT-1247424 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1247424 OMA YKRPDIL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YKRPDIL PDB 1M5G http://www.ebi.ac.uk/pdbe-srv/view/entry/1M5G PDB 2YKR http://www.ebi.ac.uk/pdbe-srv/view/entry/2YKR PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 4A2I http://www.ebi.ac.uk/pdbe-srv/view/entry/4A2I PDB 4ADV http://www.ebi.ac.uk/pdbe-srv/view/entry/4ADV PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4V47 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V47 PDB 4V48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V48 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 1M5G http://www.ebi.ac.uk/pdbsum/1M5G PDBsum 2YKR http://www.ebi.ac.uk/pdbsum/2YKR PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 4A2I http://www.ebi.ac.uk/pdbsum/4A2I PDBsum 4ADV http://www.ebi.ac.uk/pdbsum/4ADV PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4V47 http://www.ebi.ac.uk/pdbsum/4V47 PDBsum 4V48 http://www.ebi.ac.uk/pdbsum/4V48 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PRINTS PR00974 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00974 PROSITE PS00057 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00057 PSORT swissprot:RS18_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RS18_ECOLI PSORT-B swissprot:RS18_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RS18_ECOLI PSORT2 swissprot:RS18_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RS18_ECOLI Pfam PF01084 http://pfam.xfam.org/family/PF01084 Phobius swissprot:RS18_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RS18_ECOLI PhylomeDB P0A7T7 http://phylomedb.org/?seqid=P0A7T7 ProteinModelPortal P0A7T7 http://www.proteinmodelportal.org/query/uniprot/P0A7T7 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 12244297 http://www.ncbi.nlm.nih.gov/pubmed/12244297 PubMed 12809609 http://www.ncbi.nlm.nih.gov/pubmed/12809609 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3528756 http://www.ncbi.nlm.nih.gov/pubmed/3528756 PubMed 7556101 http://www.ncbi.nlm.nih.gov/pubmed/7556101 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 776663 http://www.ncbi.nlm.nih.gov/pubmed/776663 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418623 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418623 RefSeq WP_000135199 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000135199 SMR P0A7T7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7T7 STRING 511145.b4202 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4202&targetmode=cogs STRING COG0238 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0238&targetmode=cogs SUPFAM SSF46911 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46911 TIGRFAMs TIGR00165 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00165 UniProtKB RS18_ECOLI http://www.uniprot.org/uniprot/RS18_ECOLI UniProtKB-AC P0A7T7 http://www.uniprot.org/uniprot/P0A7T7 charge swissprot:RS18_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RS18_ECOLI eggNOG COG0238 http://eggnogapi.embl.de/nog_data/html/tree/COG0238 epestfind swissprot:RS18_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RS18_ECOLI garnier swissprot:RS18_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RS18_ECOLI helixturnhelix swissprot:RS18_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RS18_ECOLI hmoment swissprot:RS18_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RS18_ECOLI iep swissprot:RS18_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RS18_ECOLI inforesidue swissprot:RS18_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RS18_ECOLI octanol swissprot:RS18_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RS18_ECOLI pepcoil swissprot:RS18_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RS18_ECOLI pepdigest swissprot:RS18_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RS18_ECOLI pepinfo swissprot:RS18_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RS18_ECOLI pepnet swissprot:RS18_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RS18_ECOLI pepstats swissprot:RS18_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RS18_ECOLI pepwheel swissprot:RS18_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RS18_ECOLI pepwindow swissprot:RS18_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RS18_ECOLI sigcleave swissprot:RS18_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RS18_ECOLI ## Database ID URL or Descriptions # AltName PFLC_ECOLI Formate-C-acetyltransferase-activating enzyme 2 # AltName PFLC_ECOLI PFL-activating enzyme 2 # CATALYTIC ACTIVITY PFLC_ECOLI S-adenosyl-L-methionine + dihydroflavodoxin + [formate C-acetyltransferase]-glycine = 5'-deoxyadenosine + L- methionine + flavodoxin semiquinone + [formate C- acetyltransferase]-glycin-2-yl radical. # COFACTOR PFLC_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000250}; Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. {ECO 0000250}; # EcoGene EG11911 pflC # FUNCTION PFLC_ECOLI Activation of pyruvate formate-lyase 2 under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. {ECO 0000250}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0043365 [formate-C-acetyltransferase]-activating enzyme activity; IEA:UniProtKB-EC. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0006006 glucose metabolic process; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0044281 small molecule metabolic process # IntAct P32675 3 # InterPro IPR001989 Radical_activat_CS # InterPro IPR007197 rSAM # InterPro IPR017896 4Fe4S_Fe-S-bd # KEGG_Brite ko01000 Enzymes # Organism PFLC_ECOLI Escherichia coli (strain K12) # PATRIC 32123425 VBIEscCol129921_4073 # PIR C65202 C65202 # PROSITE PS01087 RADICAL_ACTIVATING # PROSITE PS51379 4FE4S_FER_2 # Pfam PF04055 Radical_SAM # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PFLC_ECOLI Pyruvate formate-lyase 2-activating enzyme # RefSeq NP_418387 NC_000913.3 # RefSeq WP_000204105 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAC43058.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the organic radical-activating enzymes family. {ECO 0000305}. # SIMILARITY Contains 1 4Fe-4S ferredoxin-type domain. {ECO:0000255|PROSITE-ProRule PRU00711}. # SUBCELLULAR LOCATION PFLC_ECOLI Cytoplasm {ECO 0000250}. # eggNOG COG1180 LUCA # eggNOG ENOG4108AHH Bacteria BLAST swissprot:PFLC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PFLC_ECOLI BioCyc ECOL316407:JW3924-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3924-MONOMER BioCyc EcoCyc:EG11911-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11911-MONOMER COG COG1180 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1180 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1099/13500872-141-4-961 http://dx.doi.org/10.1099/13500872-141-4-961 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.97.1.4 http://www.genome.jp/dbget-bin/www_bget?EC:1.97.1.4 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.97.1.4 http://enzyme.expasy.org/EC/1.97.1.4 EchoBASE EB1855 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1855 EcoGene EG11911 http://www.ecogene.org/geneInfo.php?eg_id=EG11911 EnsemblBacteria AAC76934 http://www.ensemblgenomes.org/id/AAC76934 EnsemblBacteria AAC76934 http://www.ensemblgenomes.org/id/AAC76934 EnsemblBacteria BAE77359 http://www.ensemblgenomes.org/id/BAE77359 EnsemblBacteria BAE77359 http://www.ensemblgenomes.org/id/BAE77359 EnsemblBacteria BAE77359 http://www.ensemblgenomes.org/id/BAE77359 EnsemblBacteria b3952 http://www.ensemblgenomes.org/id/b3952 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0043365 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043365 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0006006 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006006 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 948453 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948453 HOGENOM HOG000011459 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000011459&db=HOGENOM6 InParanoid P32675 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32675 IntAct P32675 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32675* IntEnz 1.97.1.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.97.1.4 InterPro IPR001989 http://www.ebi.ac.uk/interpro/entry/IPR001989 InterPro IPR007197 http://www.ebi.ac.uk/interpro/entry/IPR007197 InterPro IPR017896 http://www.ebi.ac.uk/interpro/entry/IPR017896 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3924 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3924 KEGG_Gene eco:b3952 http://www.genome.jp/dbget-bin/www_bget?eco:b3952 KEGG_Orthology KO:K04069 http://www.genome.jp/dbget-bin/www_bget?KO:K04069 OMA HRCPWCA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HRCPWCA PROSITE PS01087 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01087 PROSITE PS51379 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51379 PSORT swissprot:PFLC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PFLC_ECOLI PSORT-B swissprot:PFLC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PFLC_ECOLI PSORT2 swissprot:PFLC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PFLC_ECOLI Pfam PF04055 http://pfam.xfam.org/family/PF04055 Phobius swissprot:PFLC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PFLC_ECOLI PhylomeDB P32675 http://phylomedb.org/?seqid=P32675 ProteinModelPortal P32675 http://www.proteinmodelportal.org/query/uniprot/P32675 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7773398 http://www.ncbi.nlm.nih.gov/pubmed/7773398 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418387 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418387 RefSeq WP_000204105 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000204105 SMR P32675 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32675 STRING 511145.b3952 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3952&targetmode=cogs STRING COG1180 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1180&targetmode=cogs UniProtKB PFLC_ECOLI http://www.uniprot.org/uniprot/PFLC_ECOLI UniProtKB-AC P32675 http://www.uniprot.org/uniprot/P32675 charge swissprot:PFLC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PFLC_ECOLI eggNOG COG1180 http://eggnogapi.embl.de/nog_data/html/tree/COG1180 eggNOG ENOG4108AHH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108AHH epestfind swissprot:PFLC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PFLC_ECOLI garnier swissprot:PFLC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PFLC_ECOLI helixturnhelix swissprot:PFLC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PFLC_ECOLI hmoment swissprot:PFLC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PFLC_ECOLI iep swissprot:PFLC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PFLC_ECOLI inforesidue swissprot:PFLC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PFLC_ECOLI octanol swissprot:PFLC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PFLC_ECOLI pepcoil swissprot:PFLC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PFLC_ECOLI pepdigest swissprot:PFLC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PFLC_ECOLI pepinfo swissprot:PFLC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PFLC_ECOLI pepnet swissprot:PFLC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PFLC_ECOLI pepstats swissprot:PFLC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PFLC_ECOLI pepwheel swissprot:PFLC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PFLC_ECOLI pepwindow swissprot:PFLC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PFLC_ECOLI sigcleave swissprot:PFLC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PFLC_ECOLI ## Database ID URL or Descriptions # EcoGene EG14112 yfcI # IntAct P77768 3 # InterPro IPR006842 Transposase_31 # InterPro IPR010106 CHP01784 # Organism YFCI_ECOLI Escherichia coli (strain K12) # PATRIC 32119981 VBIEscCol129921_2400 # PIR G65002 G65002 # Pfam PF04754 Transposase_31 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFCI_ECOLI Uncharacterized protein YfcI # RefSeq NP_416808 NC_000913.3 # RefSeq WP_000156149 NZ_LN832404.1 # SIMILARITY Belongs to the YadD/YfaD/YhgA/YjiP family. {ECO 0000305}. # TIGRFAMs TIGR01784 T_den_put_tspse # eggNOG COG5464 LUCA # eggNOG ENOG4105DNE Bacteria BLAST swissprot:YFCI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFCI_ECOLI BioCyc ECOL316407:JW2302-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2302-MONOMER BioCyc EcoCyc:G7197-MONOMER http://biocyc.org/getid?id=EcoCyc:G7197-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3865 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3865 EcoGene EG14112 http://www.ecogene.org/geneInfo.php?eg_id=EG14112 EnsemblBacteria AAC75365 http://www.ensemblgenomes.org/id/AAC75365 EnsemblBacteria AAC75365 http://www.ensemblgenomes.org/id/AAC75365 EnsemblBacteria BAA16142 http://www.ensemblgenomes.org/id/BAA16142 EnsemblBacteria BAA16142 http://www.ensemblgenomes.org/id/BAA16142 EnsemblBacteria BAA16142 http://www.ensemblgenomes.org/id/BAA16142 EnsemblBacteria b2305 http://www.ensemblgenomes.org/id/b2305 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946787 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946787 HOGENOM HOG000116866 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000116866&db=HOGENOM6 InParanoid P77768 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77768 IntAct P77768 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77768* InterPro IPR006842 http://www.ebi.ac.uk/interpro/entry/IPR006842 InterPro IPR010106 http://www.ebi.ac.uk/interpro/entry/IPR010106 KEGG_Gene ecj:JW2302 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2302 KEGG_Gene eco:b2305 http://www.genome.jp/dbget-bin/www_bget?eco:b2305 OMA NTENCSA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NTENCSA PSORT swissprot:YFCI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFCI_ECOLI PSORT-B swissprot:YFCI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFCI_ECOLI PSORT2 swissprot:YFCI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFCI_ECOLI Pfam PF04754 http://pfam.xfam.org/family/PF04754 Phobius swissprot:YFCI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFCI_ECOLI PhylomeDB P77768 http://phylomedb.org/?seqid=P77768 ProteinModelPortal P77768 http://www.proteinmodelportal.org/query/uniprot/P77768 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416808 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416808 RefSeq WP_000156149 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000156149 STRING 511145.b2305 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2305&targetmode=cogs TIGRFAMs TIGR01784 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01784 UniProtKB YFCI_ECOLI http://www.uniprot.org/uniprot/YFCI_ECOLI UniProtKB-AC P77768 http://www.uniprot.org/uniprot/P77768 charge swissprot:YFCI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFCI_ECOLI eggNOG COG5464 http://eggnogapi.embl.de/nog_data/html/tree/COG5464 eggNOG ENOG4105DNE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DNE epestfind swissprot:YFCI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFCI_ECOLI garnier swissprot:YFCI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFCI_ECOLI helixturnhelix swissprot:YFCI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFCI_ECOLI hmoment swissprot:YFCI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFCI_ECOLI iep swissprot:YFCI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFCI_ECOLI inforesidue swissprot:YFCI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFCI_ECOLI octanol swissprot:YFCI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFCI_ECOLI pepcoil swissprot:YFCI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFCI_ECOLI pepdigest swissprot:YFCI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFCI_ECOLI pepinfo swissprot:YFCI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFCI_ECOLI pepnet swissprot:YFCI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFCI_ECOLI pepstats swissprot:YFCI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFCI_ECOLI pepwheel swissprot:YFCI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFCI_ECOLI pepwindow swissprot:YFCI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFCI_ECOLI sigcleave swissprot:YFCI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFCI_ECOLI ## Database ID URL or Descriptions # BRENDA 3.1.3.25 2026 # CATALYTIC ACTIVITY SUHB_ECOLI Myo-inositol phosphate + H(2)O = myo-inositol + phosphate. # CDD cd01639 IMPase # COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI 18420; # EcoGene EG10983 suhB # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IDA:EcoliWiki. # GO_function GO:0008934 inositol monophosphate 1-phosphatase activity; IDA:EcoliWiki. # GO_function GO:0031403 lithium ion binding; IDA:EcoliWiki. # GO_function GO:0047954 glycerol-2-phosphatase activity; IDA:EcoCyc. # GO_function GO:0052832 inositol monophosphate 3-phosphatase activity; IEA:UniProtKB-EC. # GO_function GO:0052833 inositol monophosphate 4-phosphatase activity; IEA:UniProtKB-EC. # GO_process GO:0006020 inositol metabolic process; IBA:GO_Central. # GO_process GO:0007165 signal transduction; IBA:GO_Central. # GO_process GO:0046854 phosphatidylinositol phosphorylation; IEA:InterPro. # GO_process GO:0046855 inositol phosphate dephosphorylation; IDA:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # IntAct P0ADG4 10 # InterPro IPR000760 Inositol_monophosphatase-like # InterPro IPR020550 Inositol_monophosphatase_CS # InterPro IPR020583 Inositol_monoP_metal-BS # InterPro IPR022337 Inositol_monophosphatase_SuhB # InterPro IPR033942 IMPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00521 Streptomycin biosynthesis # KEGG_Pathway ko00562 Inositol phosphate metabolism # KEGG_Pathway ko04070 Phosphatidylinositol signaling system # Organism SUHB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR20854 PTHR20854 # PATRIC 32120463 VBIEscCol129921_2634 # PDB 2QFL X-ray; 1.90 A; A=1-267 # PIR D65030 D65030 # PRINTS PR00377 IMPHPHTASES # PRINTS PR01959 SBIMPHPHTASE # PROSITE PS00629 IMP_1 # PROSITE PS00630 IMP_2 # Pfam PF00459 Inositol_P # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SUHB_ECOLI Inositol-1-monophosphatase # RefSeq NP_417028 NC_000913.3 # RefSeq WP_000553451 NZ_LN832404.1 # SIMILARITY Belongs to the inositol monophosphatase family. {ECO 0000305}. # SUBUNIT SUHB_ECOLI Monomer. # eggNOG COG0483 LUCA # eggNOG ENOG4105ECY Bacteria BLAST swissprot:SUHB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SUHB_ECOLI BioCyc ECOL316407:JW2517-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2517-MONOMER BioCyc EcoCyc:EG10983-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10983-MONOMER BioCyc MetaCyc:EG10983-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10983-MONOMER COG COG0483 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0483 DOI 10.1021/bi992424f http://dx.doi.org/10.1021/bi992424f DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.3.25 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.25 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M34828 http://www.ebi.ac.uk/ena/data/view/M34828 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.3.25 http://enzyme.expasy.org/EC/3.1.3.25 EchoBASE EB0976 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0976 EcoGene EG10983 http://www.ecogene.org/geneInfo.php?eg_id=EG10983 EnsemblBacteria AAC75586 http://www.ensemblgenomes.org/id/AAC75586 EnsemblBacteria AAC75586 http://www.ensemblgenomes.org/id/AAC75586 EnsemblBacteria BAA16427 http://www.ensemblgenomes.org/id/BAA16427 EnsemblBacteria BAA16427 http://www.ensemblgenomes.org/id/BAA16427 EnsemblBacteria BAA16427 http://www.ensemblgenomes.org/id/BAA16427 EnsemblBacteria b2533 http://www.ensemblgenomes.org/id/b2533 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0008934 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008934 GO_function GO:0031403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031403 GO_function GO:0047954 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047954 GO_function GO:0052832 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052832 GO_function GO:0052833 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052833 GO_process GO:0006020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006020 GO_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GO_process GO:0046854 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046854 GO_process GO:0046855 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046855 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 947285 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947285 HOGENOM HOG000282238 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000282238&db=HOGENOM6 InParanoid P0ADG4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADG4 IntAct P0ADG4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADG4* IntEnz 3.1.3.25 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.25 InterPro IPR000760 http://www.ebi.ac.uk/interpro/entry/IPR000760 InterPro IPR020550 http://www.ebi.ac.uk/interpro/entry/IPR020550 InterPro IPR020583 http://www.ebi.ac.uk/interpro/entry/IPR020583 InterPro IPR022337 http://www.ebi.ac.uk/interpro/entry/IPR022337 InterPro IPR033942 http://www.ebi.ac.uk/interpro/entry/IPR033942 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2517 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2517 KEGG_Gene eco:b2533 http://www.genome.jp/dbget-bin/www_bget?eco:b2533 KEGG_Orthology KO:K01092 http://www.genome.jp/dbget-bin/www_bget?KO:K01092 KEGG_Pathway ko00521 http://www.genome.jp/kegg-bin/show_pathway?ko00521 KEGG_Pathway ko00562 http://www.genome.jp/kegg-bin/show_pathway?ko00562 KEGG_Pathway ko04070 http://www.genome.jp/kegg-bin/show_pathway?ko04070 KEGG_Reaction rn:R01185 http://www.genome.jp/dbget-bin/www_bget?rn:R01185 KEGG_Reaction rn:R01186 http://www.genome.jp/dbget-bin/www_bget?rn:R01186 KEGG_Reaction rn:R01187 http://www.genome.jp/dbget-bin/www_bget?rn:R01187 OMA IGIFEDG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IGIFEDG PANTHER PTHR20854 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20854 PDB 2QFL http://www.ebi.ac.uk/pdbe-srv/view/entry/2QFL PDBsum 2QFL http://www.ebi.ac.uk/pdbsum/2QFL PRINTS PR00377 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00377 PRINTS PR01959 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01959 PROSITE PS00629 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00629 PROSITE PS00630 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00630 PSORT swissprot:SUHB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SUHB_ECOLI PSORT-B swissprot:SUHB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SUHB_ECOLI PSORT2 swissprot:SUHB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SUHB_ECOLI Pfam PF00459 http://pfam.xfam.org/family/PF00459 Phobius swissprot:SUHB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SUHB_ECOLI PhylomeDB P0ADG4 http://phylomedb.org/?seqid=P0ADG4 ProteinModelPortal P0ADG4 http://www.proteinmodelportal.org/query/uniprot/P0ADG4 PubMed 10747806 http://www.ncbi.nlm.nih.gov/pubmed/10747806 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2138605 http://www.ncbi.nlm.nih.gov/pubmed/2138605 PubMed 8002619 http://www.ncbi.nlm.nih.gov/pubmed/8002619 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417028 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417028 RefSeq WP_000553451 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000553451 SMR P0ADG4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADG4 STRING 511145.b2533 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2533&targetmode=cogs STRING COG0483 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0483&targetmode=cogs SWISS-2DPAGE P0ADG4 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0ADG4 UniProtKB SUHB_ECOLI http://www.uniprot.org/uniprot/SUHB_ECOLI UniProtKB-AC P0ADG4 http://www.uniprot.org/uniprot/P0ADG4 charge swissprot:SUHB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SUHB_ECOLI eggNOG COG0483 http://eggnogapi.embl.de/nog_data/html/tree/COG0483 eggNOG ENOG4105ECY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ECY epestfind swissprot:SUHB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SUHB_ECOLI garnier swissprot:SUHB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SUHB_ECOLI helixturnhelix swissprot:SUHB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SUHB_ECOLI hmoment swissprot:SUHB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SUHB_ECOLI iep swissprot:SUHB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SUHB_ECOLI inforesidue swissprot:SUHB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SUHB_ECOLI octanol swissprot:SUHB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SUHB_ECOLI pepcoil swissprot:SUHB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SUHB_ECOLI pepdigest swissprot:SUHB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SUHB_ECOLI pepinfo swissprot:SUHB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SUHB_ECOLI pepnet swissprot:SUHB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SUHB_ECOLI pepstats swissprot:SUHB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SUHB_ECOLI pepwheel swissprot:SUHB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SUHB_ECOLI pepwindow swissprot:SUHB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SUHB_ECOLI sigcleave swissprot:SUHB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SUHB_ECOLI ## Database ID URL or Descriptions # AltName Cobalamin receptor {ECO:0000255|HAMAP-Rule MF_01531} # AltName Outer membrane cobalamin translocator {ECO:0000255|HAMAP-Rule MF_01531} # BioGrid 4259524 246 # ENZYME REGULATION Calcium increases vitamin B12 binding affinity by a factor of 50-100. {ECO:0000269|PubMed 14499604}. # EcoGene EG10126 btuB # FUNCTION BTUB_ECOLI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB. Is also a receptor for bacteriophages BF23 and C1, and for A and E colicins. {ECO 0000269|PubMed 10485884, ECO 0000269|PubMed 2687240, ECO 0000269|PubMed 2982793}. # GO_component GO:0009279 cell outer membrane; IEA:UniProtKB-SubCell. # GO_component GO:0046930 pore complex; IEA:UniProtKB-KW. # GO_function GO:0004872 receptor activity; IEA:InterPro. # GO_function GO:0015235 cobalamin transporter activity; IEA:UniProtKB-HAMAP. # GO_function GO:0015288 porin activity; IEA:UniProtKB-KW. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006811 ion transport; IEA:UniProtKB-KW. # GO_process GO:0015889 cobalamin transport; IMP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # Gene3D 2.170.130.10 -; 1. # Gene3D 2.40.170.20 -; 1. # HAMAP MF_01531 BtuB # INDUCTION Constitutively expressed. Primary control of btuB expression by cobalamin occurs at the level of translation initiation. {ECO:0000269|PubMed 9852020}. # InterPro IPR000531 TonB-dep_rcpt_b-brl # InterPro IPR010101 B12_transptr_BtuB # InterPro IPR010916 TonB_box_CS # InterPro IPR010917 TonB_rcpt_CS # InterPro IPR012910 Plug_dom # KEGG_Brite ko02000 Transporters # Organism BTUB_ECOLI Escherichia coli (strain K12) # PATRIC 32123453 VBIEscCol129921_4087 # PDB 1NQE X-ray; 2.00 A; A=21-614 # PDB 1NQF X-ray; 2.70 A; A=21-614 # PDB 1NQG X-ray; 3.31 A; A=21-614 # PDB 1NQH X-ray; 3.10 A; A=21-614 # PDB 1UJW X-ray; 2.75 A; A=21-614 # PDB 2GSK X-ray; 2.10 A; A=25-614 # PDB 2GUF X-ray; 1.95 A; A=21-614 # PDB 2YSU X-ray; 3.50 A; A=21-614 # PDB 3M8B X-ray; 2.44 A; A=21-614 # PDB 3M8D X-ray; 2.44 A; A=21-614 # PDB 3RGM X-ray; 2.60 A; A=21-614 # PDB 3RGN X-ray; 2.30 A; A=21-614 # PIR A65204 QRECBT # PROSITE PS00430 TONB_DEPENDENT_REC_1 # PROSITE PS01156 TONB_DEPENDENT_REC_2 # Pfam PF00593 TonB_dep_Rec # Pfam PF07715 Plug # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Vitamin B12 transporter BtuB {ECO:0000255|HAMAP-Rule MF_01531} # RefSeq NP_418401 NC_000913.3 # RefSeq WP_000591359 NZ_LN832404.1 # SIMILARITY Belongs to the TonB-dependent receptor family. BtuB (TC 1.B.14.3.1) subfamily. {ECO:0000255|HAMAP-Rule MF_01531, ECO:0000305}. # SUBCELLULAR LOCATION BTUB_ECOLI Cell outer membrane {ECO 0000269|PubMed 12595710, ECO 0000269|PubMed 12652322, ECO 0000269|PubMed 2687240, ECO 0000269|PubMed 2982793}; Multi- pass membrane protein {ECO 0000269|PubMed 12595710, ECO 0000269|PubMed 12652322, ECO 0000269|PubMed 2687240, ECO 0000269|PubMed 2982793}. # SUBUNIT BTUB_ECOLI Interacts with TonB. {ECO 0000269|PubMed 10485884, ECO 0000269|PubMed 14528295}. # TCDB 1.B.14.3 the outer membrane receptor (omr) family # TIGRFAMs TIGR01779 TonB-B12 # eggNOG COG4206 LUCA # eggNOG ENOG4105CHI Bacteria BLAST swissprot:BTUB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BTUB_ECOLI BioCyc ECOL316407:JW3938-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3938-MONOMER BioCyc EcoCyc:EG10126-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10126-MONOMER BioCyc MetaCyc:EG10126-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10126-MONOMER COG COG4206 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4206 DIP DIP-9232N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9232N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1016/j.jmb.2003.07.005 http://dx.doi.org/10.1016/j.jmb.2003.07.005 DOI 10.1021/bi015602p http://dx.doi.org/10.1021/bi015602p DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb914 http://dx.doi.org/10.1038/nsb914 DOI 10.1038/nsb997 http://dx.doi.org/10.1038/nsb997 DOI 10.1073/pnas.96.19.10673 http://dx.doi.org/10.1073/pnas.96.19.10673 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1107/S0907444903000052 http://dx.doi.org/10.1107/S0907444903000052 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L14556 http://www.ebi.ac.uk/ena/data/view/L14556 EMBL M10112 http://www.ebi.ac.uk/ena/data/view/M10112 EMBL M57568 http://www.ebi.ac.uk/ena/data/view/M57568 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0124 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0124 EcoGene EG10126 http://www.ecogene.org/geneInfo.php?eg_id=EG10126 EnsemblBacteria AAC76948 http://www.ensemblgenomes.org/id/AAC76948 EnsemblBacteria AAC76948 http://www.ensemblgenomes.org/id/AAC76948 EnsemblBacteria BAE77345 http://www.ensemblgenomes.org/id/BAE77345 EnsemblBacteria BAE77345 http://www.ensemblgenomes.org/id/BAE77345 EnsemblBacteria BAE77345 http://www.ensemblgenomes.org/id/BAE77345 EnsemblBacteria b3966 http://www.ensemblgenomes.org/id/b3966 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0046930 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046930 GO_function GO:0004872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004872 GO_function GO:0015235 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015235 GO_function GO:0015288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015288 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006811 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811 GO_process GO:0015889 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015889 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 2.170.130.10 http://www.cathdb.info/version/latest/superfamily/2.170.130.10 Gene3D 2.40.170.20 http://www.cathdb.info/version/latest/superfamily/2.40.170.20 GeneID 948468 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948468 HAMAP MF_01531 http://hamap.expasy.org/unirule/MF_01531 HOGENOM HOG000269547 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000269547&db=HOGENOM6 InParanoid P06129 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P06129 IntAct P06129 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P06129* InterPro IPR000531 http://www.ebi.ac.uk/interpro/entry/IPR000531 InterPro IPR010101 http://www.ebi.ac.uk/interpro/entry/IPR010101 InterPro IPR010916 http://www.ebi.ac.uk/interpro/entry/IPR010916 InterPro IPR010917 http://www.ebi.ac.uk/interpro/entry/IPR010917 InterPro IPR012910 http://www.ebi.ac.uk/interpro/entry/IPR012910 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3938 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3938 KEGG_Gene eco:b3966 http://www.genome.jp/dbget-bin/www_bget?eco:b3966 KEGG_Orthology KO:K16092 http://www.genome.jp/dbget-bin/www_bget?KO:K16092 OMA NRDIYST http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NRDIYST PDB 1NQE http://www.ebi.ac.uk/pdbe-srv/view/entry/1NQE PDB 1NQF http://www.ebi.ac.uk/pdbe-srv/view/entry/1NQF PDB 1NQG http://www.ebi.ac.uk/pdbe-srv/view/entry/1NQG PDB 1NQH http://www.ebi.ac.uk/pdbe-srv/view/entry/1NQH PDB 1UJW http://www.ebi.ac.uk/pdbe-srv/view/entry/1UJW PDB 2GSK http://www.ebi.ac.uk/pdbe-srv/view/entry/2GSK PDB 2GUF http://www.ebi.ac.uk/pdbe-srv/view/entry/2GUF PDB 2YSU http://www.ebi.ac.uk/pdbe-srv/view/entry/2YSU PDB 3M8B http://www.ebi.ac.uk/pdbe-srv/view/entry/3M8B PDB 3M8D http://www.ebi.ac.uk/pdbe-srv/view/entry/3M8D PDB 3RGM http://www.ebi.ac.uk/pdbe-srv/view/entry/3RGM PDB 3RGN http://www.ebi.ac.uk/pdbe-srv/view/entry/3RGN PDBsum 1NQE http://www.ebi.ac.uk/pdbsum/1NQE PDBsum 1NQF http://www.ebi.ac.uk/pdbsum/1NQF PDBsum 1NQG http://www.ebi.ac.uk/pdbsum/1NQG PDBsum 1NQH http://www.ebi.ac.uk/pdbsum/1NQH PDBsum 1UJW http://www.ebi.ac.uk/pdbsum/1UJW PDBsum 2GSK http://www.ebi.ac.uk/pdbsum/2GSK PDBsum 2GUF http://www.ebi.ac.uk/pdbsum/2GUF PDBsum 2YSU http://www.ebi.ac.uk/pdbsum/2YSU PDBsum 3M8B http://www.ebi.ac.uk/pdbsum/3M8B PDBsum 3M8D http://www.ebi.ac.uk/pdbsum/3M8D PDBsum 3RGM http://www.ebi.ac.uk/pdbsum/3RGM PDBsum 3RGN http://www.ebi.ac.uk/pdbsum/3RGN PROSITE PS00430 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00430 PROSITE PS01156 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01156 PSORT swissprot:BTUB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BTUB_ECOLI PSORT-B swissprot:BTUB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BTUB_ECOLI PSORT2 swissprot:BTUB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BTUB_ECOLI Pfam PF00593 http://pfam.xfam.org/family/PF00593 Pfam PF07715 http://pfam.xfam.org/family/PF07715 Phobius swissprot:BTUB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BTUB_ECOLI PhylomeDB P06129 http://phylomedb.org/?seqid=P06129 ProteinModelPortal P06129 http://www.proteinmodelportal.org/query/uniprot/P06129 PubMed 10485884 http://www.ncbi.nlm.nih.gov/pubmed/10485884 PubMed 11705387 http://www.ncbi.nlm.nih.gov/pubmed/11705387 PubMed 12595710 http://www.ncbi.nlm.nih.gov/pubmed/12595710 PubMed 12652322 http://www.ncbi.nlm.nih.gov/pubmed/12652322 PubMed 14499604 http://www.ncbi.nlm.nih.gov/pubmed/14499604 PubMed 14528295 http://www.ncbi.nlm.nih.gov/pubmed/14528295 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1999392 http://www.ncbi.nlm.nih.gov/pubmed/1999392 PubMed 2687240 http://www.ncbi.nlm.nih.gov/pubmed/2687240 PubMed 2982793 http://www.ncbi.nlm.nih.gov/pubmed/2982793 PubMed 3882670 http://www.ncbi.nlm.nih.gov/pubmed/3882670 PubMed 8093236 http://www.ncbi.nlm.nih.gov/pubmed/8093236 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9852020 http://www.ncbi.nlm.nih.gov/pubmed/9852020 RefSeq NP_418401 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418401 RefSeq WP_000591359 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000591359 SMR P06129 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P06129 STRING 511145.b3966 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3966&targetmode=cogs STRING COG4206 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4206&targetmode=cogs TCDB 1.B.14.3 http://www.tcdb.org/search/result.php?tc=1.B.14.3 TIGRFAMs TIGR01779 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01779 UniProtKB BTUB_ECOLI http://www.uniprot.org/uniprot/BTUB_ECOLI UniProtKB-AC P06129 http://www.uniprot.org/uniprot/P06129 charge swissprot:BTUB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BTUB_ECOLI eggNOG COG4206 http://eggnogapi.embl.de/nog_data/html/tree/COG4206 eggNOG ENOG4105CHI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CHI epestfind swissprot:BTUB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BTUB_ECOLI garnier swissprot:BTUB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BTUB_ECOLI helixturnhelix swissprot:BTUB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BTUB_ECOLI hmoment swissprot:BTUB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BTUB_ECOLI iep swissprot:BTUB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BTUB_ECOLI inforesidue swissprot:BTUB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BTUB_ECOLI octanol swissprot:BTUB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BTUB_ECOLI pepcoil swissprot:BTUB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BTUB_ECOLI pepdigest swissprot:BTUB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BTUB_ECOLI pepinfo swissprot:BTUB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BTUB_ECOLI pepnet swissprot:BTUB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BTUB_ECOLI pepstats swissprot:BTUB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BTUB_ECOLI pepwheel swissprot:BTUB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BTUB_ECOLI pepwindow swissprot:BTUB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BTUB_ECOLI sigcleave swissprot:BTUB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BTUB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260070 182 # EcoGene EG20263 flgA # FUNCTION FLGA_ECOLI Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_process GO:0044781 bacterial-type flagellum organization; IEA:UniProtKB-KW. # GO_process GO:0071973 bacterial-type flagellum-dependent cell motility; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0008150 biological_process # GOslim_process GO:0048870 cell motility # IntAct P75933 2 # InterPro IPR013974 SAF # InterPro IPR017585 Flag_basal_body_FlgA_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Pathway ko02040 Flagellar assembly # Organism FLGA_ECOLI Escherichia coli (strain K12) # PATRIC 32117383 VBIEscCol129921_1114 # PIR E64850 E64850 # Pfam PF13144 ChapFlgA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FLGA_ECOLI Flagella basal body P-ring formation protein FlgA # RefSeq NP_415590 NC_000913.3 # RefSeq WP_000905458 NZ_LN832404.1 # SIMILARITY Belongs to the FlgA family. {ECO 0000305}. # SMART SM00858 SAF # SUBCELLULAR LOCATION FLGA_ECOLI Periplasm {ECO 0000305}. # TIGRFAMs TIGR03170 flgA_cterm # eggNOG COG1261 LUCA # eggNOG ENOG4105CKS Bacteria BLAST swissprot:FLGA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLGA_ECOLI BioCyc ECOL316407:JW1059-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1059-MONOMER BioCyc EcoCyc:G357-MONOMER http://biocyc.org/getid?id=EcoCyc:G357-MONOMER COG COG1261 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1261 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4160 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4160 EcoGene EG20263 http://www.ecogene.org/geneInfo.php?eg_id=EG20263 EnsemblBacteria AAC74156 http://www.ensemblgenomes.org/id/AAC74156 EnsemblBacteria AAC74156 http://www.ensemblgenomes.org/id/AAC74156 EnsemblBacteria BAA35880 http://www.ensemblgenomes.org/id/BAA35880 EnsemblBacteria BAA35880 http://www.ensemblgenomes.org/id/BAA35880 EnsemblBacteria BAA35880 http://www.ensemblgenomes.org/id/BAA35880 EnsemblBacteria b1072 http://www.ensemblgenomes.org/id/b1072 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_process GO:0044781 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044781 GO_process GO:0071973 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071973 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 GeneID 946300 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946300 HOGENOM HOG000119039 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000119039&db=HOGENOM6 InParanoid P75933 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75933 IntAct P75933 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75933* InterPro IPR013974 http://www.ebi.ac.uk/interpro/entry/IPR013974 InterPro IPR017585 http://www.ebi.ac.uk/interpro/entry/IPR017585 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW1059 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1059 KEGG_Gene eco:b1072 http://www.genome.jp/dbget-bin/www_bget?eco:b1072 KEGG_Orthology KO:K02386 http://www.genome.jp/dbget-bin/www_bget?KO:K02386 KEGG_Pathway ko02040 http://www.genome.jp/kegg-bin/show_pathway?ko02040 OMA FFQQQYP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FFQQQYP PSORT swissprot:FLGA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLGA_ECOLI PSORT-B swissprot:FLGA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLGA_ECOLI PSORT2 swissprot:FLGA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLGA_ECOLI Pfam PF13144 http://pfam.xfam.org/family/PF13144 Phobius swissprot:FLGA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLGA_ECOLI ProteinModelPortal P75933 http://www.proteinmodelportal.org/query/uniprot/P75933 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415590 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415590 RefSeq WP_000905458 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000905458 SMART SM00858 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00858 SMR P75933 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75933 STRING 511145.b1072 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1072&targetmode=cogs STRING COG1261 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1261&targetmode=cogs TIGRFAMs TIGR03170 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03170 UniProtKB FLGA_ECOLI http://www.uniprot.org/uniprot/FLGA_ECOLI UniProtKB-AC P75933 http://www.uniprot.org/uniprot/P75933 charge swissprot:FLGA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLGA_ECOLI eggNOG COG1261 http://eggnogapi.embl.de/nog_data/html/tree/COG1261 eggNOG ENOG4105CKS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CKS epestfind swissprot:FLGA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLGA_ECOLI garnier swissprot:FLGA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLGA_ECOLI helixturnhelix swissprot:FLGA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLGA_ECOLI hmoment swissprot:FLGA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLGA_ECOLI iep swissprot:FLGA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLGA_ECOLI inforesidue swissprot:FLGA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLGA_ECOLI octanol swissprot:FLGA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLGA_ECOLI pepcoil swissprot:FLGA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLGA_ECOLI pepdigest swissprot:FLGA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLGA_ECOLI pepinfo swissprot:FLGA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLGA_ECOLI pepnet swissprot:FLGA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLGA_ECOLI pepstats swissprot:FLGA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLGA_ECOLI pepwheel swissprot:FLGA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLGA_ECOLI pepwindow swissprot:FLGA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLGA_ECOLI sigcleave swissprot:FLGA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLGA_ECOLI ## Database ID URL or Descriptions # EcoGene EG11922 yjbD # IntAct P32685 6 # InterPro IPR020317 Uncharacterised_YjbD # Organism YJBD_ECOLI Escherichia coli (strain K12) # PATRIC 32123575 VBIEscCol129921_4136 # PIR F65209 F65209 # Pfam PF11656 DUF3811 # ProDom PD063639 Uncharacterised_YjbD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJBD_ECOLI Uncharacterized protein YjbD # RefSeq NP_418447 NC_000913.3 # RefSeq WP_001207634 NZ_LN832404.1 # eggNOG ENOG4108ZR5 Bacteria # eggNOG ENOG4111P78 LUCA BLAST swissprot:YJBD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJBD_ECOLI BioCyc ECOL316407:JW3983-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3983-MONOMER BioCyc EcoCyc:EG11922-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11922-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1866 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1866 EcoGene EG11922 http://www.ecogene.org/geneInfo.php?eg_id=EG11922 EnsemblBacteria AAC76993 http://www.ensemblgenomes.org/id/AAC76993 EnsemblBacteria AAC76993 http://www.ensemblgenomes.org/id/AAC76993 EnsemblBacteria BAE78025 http://www.ensemblgenomes.org/id/BAE78025 EnsemblBacteria BAE78025 http://www.ensemblgenomes.org/id/BAE78025 EnsemblBacteria BAE78025 http://www.ensemblgenomes.org/id/BAE78025 EnsemblBacteria b4023 http://www.ensemblgenomes.org/id/b4023 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 948518 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948518 HOGENOM HOG000126842 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126842&db=HOGENOM6 IntAct P32685 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32685* InterPro IPR020317 http://www.ebi.ac.uk/interpro/entry/IPR020317 KEGG_Gene ecj:JW3983 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3983 KEGG_Gene eco:b4023 http://www.genome.jp/dbget-bin/www_bget?eco:b4023 OMA AYKPDAE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AYKPDAE PSORT swissprot:YJBD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJBD_ECOLI PSORT-B swissprot:YJBD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJBD_ECOLI PSORT2 swissprot:YJBD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJBD_ECOLI Pfam PF11656 http://pfam.xfam.org/family/PF11656 Phobius swissprot:YJBD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJBD_ECOLI ProteinModelPortal P32685 http://www.proteinmodelportal.org/query/uniprot/P32685 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418447 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418447 RefSeq WP_001207634 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001207634 STRING 511145.b4023 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4023&targetmode=cogs UniProtKB YJBD_ECOLI http://www.uniprot.org/uniprot/YJBD_ECOLI UniProtKB-AC P32685 http://www.uniprot.org/uniprot/P32685 charge swissprot:YJBD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJBD_ECOLI eggNOG ENOG4108ZR5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZR5 eggNOG ENOG4111P78 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111P78 epestfind swissprot:YJBD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJBD_ECOLI garnier swissprot:YJBD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJBD_ECOLI helixturnhelix swissprot:YJBD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJBD_ECOLI hmoment swissprot:YJBD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJBD_ECOLI iep swissprot:YJBD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJBD_ECOLI inforesidue swissprot:YJBD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJBD_ECOLI octanol swissprot:YJBD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJBD_ECOLI pepcoil swissprot:YJBD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJBD_ECOLI pepdigest swissprot:YJBD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJBD_ECOLI pepinfo swissprot:YJBD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJBD_ECOLI pepnet swissprot:YJBD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJBD_ECOLI pepstats swissprot:YJBD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJBD_ECOLI pepwheel swissprot:YJBD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJBD_ECOLI pepwindow swissprot:YJBD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJBD_ECOLI sigcleave swissprot:YJBD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJBD_ECOLI ## Database ID URL or Descriptions # AltName PNCC_ECOLI NMN deamidase # AltName PNCC_ECOLI Nicotinamide-nucleotide amidase # BIOPHYSICOCHEMICAL PROPERTIES PNCC_ECOLI Kinetic parameters KM=6 uM for NMN {ECO 0000269|PubMed 21953451}; Note=Kcat is 3.3 s (-1).; pH dependence Optimum pH active over a broad range of pH values. {ECO 0000269|PubMed 21953451}; # BioGrid 4262070 139 # CATALYTIC ACTIVITY Beta-nicotinamide D-ribonucleotide + H(2)O = beta-nicotinate D-ribonucleotide + NH(3). {ECO:0000269|PubMed 21953451}. # EcoGene EG12698 pncC # FUNCTION PNCC_ECOLI Has nicotinamidemononucleotide (NMN) aminohydrolase activity, not active on other substrates. {ECO 0000269|PubMed 21953451}. # GO_function GO:0019159 nicotinamide-nucleotide amidase activity; IDA:EcoCyc. # GO_process GO:0019363 pyridine nucleotide biosynthetic process; IEA:UniProtKB-KW. # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.90.950.20 -; 1. # IntAct P0A6G3 8 # InterPro IPR008136 CinA_C # Organism PNCC_ECOLI Escherichia coli (strain K12) # PATRIC 32120798 VBIEscCol129921_2791 # PIR H65049 H65049 # Pfam PF02464 CinA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PNCC_ECOLI Nicotinamide-nucleotide amidohydrolase PncC # RefSeq NP_417180 NC_000913.3 # RefSeq WP_000132231 NZ_LN832404.1 # SIMILARITY Belongs to the CinA family. PncC subfamily. {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000305|PubMed 21953451}. # SUPFAM SSF142433 SSF142433 # TIGRFAMs TIGR00199 PncC_domain # eggNOG COG1546 LUCA # eggNOG ENOG4107TH8 Bacteria BLAST swissprot:PNCC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PNCC_ECOLI BioCyc ECOL316407:JW2670-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2670-MONOMER BioCyc EcoCyc:G7409-MONOMER http://biocyc.org/getid?id=EcoCyc:G7409-MONOMER BioCyc MetaCyc:G7409-MONOMER http://biocyc.org/getid?id=MetaCyc:G7409-MONOMER COG COG1546 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1546 DIP DIP-48189N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48189N DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.77.5.2611 http://dx.doi.org/10.1073/pnas.77.5.2611 DOI 10.1074/jbc.M111.275818 http://dx.doi.org/10.1074/jbc.M111.275818 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1365-2958.1995.tb02437.x http://dx.doi.org/10.1111/j.1365-2958.1995.tb02437.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.5.1.42 http://www.genome.jp/dbget-bin/www_bget?EC:3.5.1.42 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18785 http://www.ebi.ac.uk/ena/data/view/U18785 EMBL V00328 http://www.ebi.ac.uk/ena/data/view/V00328 ENZYME 3.5.1.42 http://enzyme.expasy.org/EC/3.5.1.42 EchoBASE EB2560 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2560 EcoGene EG12698 http://www.ecogene.org/geneInfo.php?eg_id=EG12698 EnsemblBacteria AAC75742 http://www.ensemblgenomes.org/id/AAC75742 EnsemblBacteria AAC75742 http://www.ensemblgenomes.org/id/AAC75742 EnsemblBacteria BAA16562 http://www.ensemblgenomes.org/id/BAA16562 EnsemblBacteria BAA16562 http://www.ensemblgenomes.org/id/BAA16562 EnsemblBacteria BAA16562 http://www.ensemblgenomes.org/id/BAA16562 EnsemblBacteria b2700 http://www.ensemblgenomes.org/id/b2700 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0019159 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019159 GO_process GO:0019363 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019363 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.90.950.20 http://www.cathdb.info/version/latest/superfamily/3.90.950.20 GeneID 947169 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947169 HOGENOM HOG000242527 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000242527&db=HOGENOM6 InParanoid P0A6G3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6G3 IntAct P0A6G3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6G3* IntEnz 3.5.1.42 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.1.42 InterPro IPR008136 http://www.ebi.ac.uk/interpro/entry/IPR008136 KEGG_Gene ecj:JW2670 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2670 KEGG_Gene eco:b2700 http://www.genome.jp/dbget-bin/www_bget?eco:b2700 KEGG_Orthology KO:K03743 http://www.genome.jp/dbget-bin/www_bget?KO:K03743 OMA EMIGVPP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EMIGVPP PSORT swissprot:PNCC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PNCC_ECOLI PSORT-B swissprot:PNCC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PNCC_ECOLI PSORT2 swissprot:PNCC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PNCC_ECOLI Pfam PF02464 http://pfam.xfam.org/family/PF02464 Phobius swissprot:PNCC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PNCC_ECOLI PhylomeDB P0A6G3 http://phylomedb.org/?seqid=P0A6G3 ProteinModelPortal P0A6G3 http://www.proteinmodelportal.org/query/uniprot/P0A6G3 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21953451 http://www.ncbi.nlm.nih.gov/pubmed/21953451 PubMed 6930655 http://www.ncbi.nlm.nih.gov/pubmed/6930655 PubMed 7476170 http://www.ncbi.nlm.nih.gov/pubmed/7476170 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417180 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417180 RefSeq WP_000132231 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000132231 SMR P0A6G3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6G3 STRING 511145.b2700 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2700&targetmode=cogs STRING COG1546 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1546&targetmode=cogs SUPFAM SSF142433 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF142433 TIGRFAMs TIGR00199 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00199 UniProtKB PNCC_ECOLI http://www.uniprot.org/uniprot/PNCC_ECOLI UniProtKB-AC P0A6G3 http://www.uniprot.org/uniprot/P0A6G3 charge swissprot:PNCC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PNCC_ECOLI eggNOG COG1546 http://eggnogapi.embl.de/nog_data/html/tree/COG1546 eggNOG ENOG4107TH8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107TH8 epestfind swissprot:PNCC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PNCC_ECOLI garnier swissprot:PNCC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PNCC_ECOLI helixturnhelix swissprot:PNCC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PNCC_ECOLI hmoment swissprot:PNCC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PNCC_ECOLI iep swissprot:PNCC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PNCC_ECOLI inforesidue swissprot:PNCC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PNCC_ECOLI octanol swissprot:PNCC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PNCC_ECOLI pepcoil swissprot:PNCC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PNCC_ECOLI pepdigest swissprot:PNCC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PNCC_ECOLI pepinfo swissprot:PNCC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PNCC_ECOLI pepnet swissprot:PNCC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PNCC_ECOLI pepstats swissprot:PNCC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PNCC_ECOLI pepwheel swissprot:PNCC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PNCC_ECOLI pepwindow swissprot:PNCC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PNCC_ECOLI sigcleave swissprot:PNCC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PNCC_ECOLI ## Database ID URL or Descriptions # BioGrid 4260747 305 # EcoGene EG14164 yfeW # GO_component GO:0031226 intrinsic component of plasma membrane; IDA:EcoCyc. # GO_function GO:0008658 penicillin binding; IDA:EcoCyc. # GO_function GO:0009002 serine-type D-Ala-D-Ala carboxypeptidase activity; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.710.10 -; 1. # HAMAP MF_01034 UPF0214 # InterPro IPR001466 Beta-lactam-related # InterPro IPR012338 Beta-lactam/transpept-like # InterPro IPR022849 Pept_S12_UPF0214_YfeW-type # Organism YFEW_ECOLI Escherichia coli (strain K12) # PATRIC 32120245 VBIEscCol129921_2525 # PIR E65017 E65017 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF00144 Beta-lactamase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFEW_ECOLI UPF0214 protein YfeW # RefSeq NP_416925 NC_000913.3 # RefSeq WP_001327042 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0214 family. {ECO 0000305}. # SUPFAM SSF56601 SSF56601 # eggNOG COG1680 LUCA # eggNOG ENOG4107S1E Bacteria BLAST swissprot:YFEW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFEW_ECOLI BioCyc ECOL316407:JW5395-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5395-MONOMER BioCyc EcoCyc:G7265-MONOMER http://biocyc.org/getid?id=EcoCyc:G7265-MONOMER BioCyc MetaCyc:G7265-MONOMER http://biocyc.org/getid?id=MetaCyc:G7265-MONOMER DIP DIP-12021N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12021N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3916 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3916 EcoGene EG14164 http://www.ecogene.org/geneInfo.php?eg_id=EG14164 EnsemblBacteria AAC75483 http://www.ensemblgenomes.org/id/AAC75483 EnsemblBacteria AAC75483 http://www.ensemblgenomes.org/id/AAC75483 EnsemblBacteria BAA16314 http://www.ensemblgenomes.org/id/BAA16314 EnsemblBacteria BAA16314 http://www.ensemblgenomes.org/id/BAA16314 EnsemblBacteria BAA16314 http://www.ensemblgenomes.org/id/BAA16314 EnsemblBacteria b2430 http://www.ensemblgenomes.org/id/b2430 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0031226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031226 GO_function GO:0008658 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008658 GO_function GO:0009002 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009002 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.710.10 http://www.cathdb.info/version/latest/superfamily/3.40.710.10 GeneID 946907 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946907 HAMAP MF_01034 http://hamap.expasy.org/unirule/MF_01034 HOGENOM HOG000008712 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000008712&db=HOGENOM6 InParanoid P77619 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77619 InterPro IPR001466 http://www.ebi.ac.uk/interpro/entry/IPR001466 InterPro IPR012338 http://www.ebi.ac.uk/interpro/entry/IPR012338 InterPro IPR022849 http://www.ebi.ac.uk/interpro/entry/IPR022849 KEGG_Gene ecj:JW5395 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5395 KEGG_Gene eco:b2430 http://www.genome.jp/dbget-bin/www_bget?eco:b2430 OMA PMANMLA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PMANMLA PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YFEW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFEW_ECOLI PSORT-B swissprot:YFEW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFEW_ECOLI PSORT2 swissprot:YFEW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFEW_ECOLI Pfam PF00144 http://pfam.xfam.org/family/PF00144 Phobius swissprot:YFEW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFEW_ECOLI PhylomeDB P77619 http://phylomedb.org/?seqid=P77619 ProteinModelPortal P77619 http://www.proteinmodelportal.org/query/uniprot/P77619 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416925 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416925 RefSeq WP_001327042 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001327042 STRING 511145.b2430 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2430&targetmode=cogs SUPFAM SSF56601 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56601 UniProtKB YFEW_ECOLI http://www.uniprot.org/uniprot/YFEW_ECOLI UniProtKB-AC P77619 http://www.uniprot.org/uniprot/P77619 charge swissprot:YFEW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFEW_ECOLI eggNOG COG1680 http://eggnogapi.embl.de/nog_data/html/tree/COG1680 eggNOG ENOG4107S1E http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107S1E epestfind swissprot:YFEW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFEW_ECOLI garnier swissprot:YFEW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFEW_ECOLI helixturnhelix swissprot:YFEW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFEW_ECOLI hmoment swissprot:YFEW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFEW_ECOLI iep swissprot:YFEW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFEW_ECOLI inforesidue swissprot:YFEW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFEW_ECOLI octanol swissprot:YFEW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFEW_ECOLI pepcoil swissprot:YFEW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFEW_ECOLI pepdigest swissprot:YFEW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFEW_ECOLI pepinfo swissprot:YFEW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFEW_ECOLI pepnet swissprot:YFEW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFEW_ECOLI pepstats swissprot:YFEW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFEW_ECOLI pepwheel swissprot:YFEW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFEW_ECOLI pepwindow swissprot:YFEW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFEW_ECOLI sigcleave swissprot:YFEW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFEW_ECOLI ## Database ID URL or Descriptions # BioGrid 4261307 17 # EcoGene EG12142 sdaC # FUNCTION SDAC_ECOLI Involved in the import of serine into the cell. May be required for phage C1 adsorption by interacting with DrcB. May also be involved in ampicillin sensitivity. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoliWiki. # GO_function GO:0005215 transporter activity; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # INDUCTION By leucine and by growth in rich medium. Repressed by LeuO. Part of the sdaCB operon. {ECO:0000269|PubMed 19429622}. # InterPro IPR004694 Hydroxy_aa_transpt # KEGG_Brite ko02000 Transporters # Organism SDAC_ECOLI Escherichia coli (strain K12) # PATRIC 32121008 VBIEscCol129921_2896 # PIR S45633 S45633 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SDAC_ECOLI Serine transporter # RefSeq NP_417276 NC_000913.3 # RefSeq WP_000450476 NZ_LN832404.1 # SIMILARITY Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION SDAC_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.42.2 the hydroxy/aromatic amino acid permease (haaap) family # TIGRFAMs TIGR00814 stp # eggNOG COG0814 LUCA # eggNOG ENOG4105C44 Bacteria BLAST swissprot:SDAC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SDAC_ECOLI BioCyc ECOL316407:JW2767-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2767-MONOMER BioCyc EcoCyc:SDAC-MONOMER http://biocyc.org/getid?id=EcoCyc:SDAC-MONOMER BioCyc MetaCyc:SDAC-MONOMER http://biocyc.org/getid?id=MetaCyc:SDAC-MONOMER COG COG0814 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0814 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1432-1033.1994.tb18938.x http://dx.doi.org/10.1111/j.1432-1033.1994.tb18938.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00108-09 http://dx.doi.org/10.1128/JB.00108-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U01233 http://www.ebi.ac.uk/ena/data/view/U01233 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 EchoBASE EB2063 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2063 EcoGene EG12142 http://www.ecogene.org/geneInfo.php?eg_id=EG12142 EnsemblBacteria AAC75838 http://www.ensemblgenomes.org/id/AAC75838 EnsemblBacteria AAC75838 http://www.ensemblgenomes.org/id/AAC75838 EnsemblBacteria BAE76868 http://www.ensemblgenomes.org/id/BAE76868 EnsemblBacteria BAE76868 http://www.ensemblgenomes.org/id/BAE76868 EnsemblBacteria BAE76868 http://www.ensemblgenomes.org/id/BAE76868 EnsemblBacteria b2796 http://www.ensemblgenomes.org/id/b2796 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GeneID 947264 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947264 HOGENOM HOG000270787 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000270787&db=HOGENOM6 InterPro IPR004694 http://www.ebi.ac.uk/interpro/entry/IPR004694 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2767 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2767 KEGG_Gene eco:b2796 http://www.genome.jp/dbget-bin/www_bget?eco:b2796 KEGG_Orthology KO:K03837 http://www.genome.jp/dbget-bin/www_bget?KO:K03837 OMA HQLHLPS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HQLHLPS PSORT swissprot:SDAC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SDAC_ECOLI PSORT-B swissprot:SDAC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SDAC_ECOLI PSORT2 swissprot:SDAC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SDAC_ECOLI Phobius swissprot:SDAC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SDAC_ECOLI PhylomeDB P0AAD6 http://phylomedb.org/?seqid=P0AAD6 ProteinModelPortal P0AAD6 http://www.proteinmodelportal.org/query/uniprot/P0AAD6 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19429622 http://www.ncbi.nlm.nih.gov/pubmed/19429622 PubMed 8026499 http://www.ncbi.nlm.nih.gov/pubmed/8026499 PubMed 8752353 http://www.ncbi.nlm.nih.gov/pubmed/8752353 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417276 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417276 RefSeq WP_000450476 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000450476 STRING 511145.b2796 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2796&targetmode=cogs STRING COG0814 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0814&targetmode=cogs TCDB 2.A.42.2 http://www.tcdb.org/search/result.php?tc=2.A.42.2 TIGRFAMs TIGR00814 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00814 UniProtKB SDAC_ECOLI http://www.uniprot.org/uniprot/SDAC_ECOLI UniProtKB-AC P0AAD6 http://www.uniprot.org/uniprot/P0AAD6 charge swissprot:SDAC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SDAC_ECOLI eggNOG COG0814 http://eggnogapi.embl.de/nog_data/html/tree/COG0814 eggNOG ENOG4105C44 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C44 epestfind swissprot:SDAC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SDAC_ECOLI garnier swissprot:SDAC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SDAC_ECOLI helixturnhelix swissprot:SDAC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SDAC_ECOLI hmoment swissprot:SDAC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SDAC_ECOLI iep swissprot:SDAC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SDAC_ECOLI inforesidue swissprot:SDAC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SDAC_ECOLI octanol swissprot:SDAC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SDAC_ECOLI pepcoil swissprot:SDAC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SDAC_ECOLI pepdigest swissprot:SDAC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SDAC_ECOLI pepinfo swissprot:SDAC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SDAC_ECOLI pepnet swissprot:SDAC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SDAC_ECOLI pepstats swissprot:SDAC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SDAC_ECOLI pepwheel swissprot:SDAC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SDAC_ECOLI pepwindow swissprot:SDAC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SDAC_ECOLI sigcleave swissprot:SDAC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SDAC_ECOLI ## Database ID URL or Descriptions # AltName AK2H_ECOLI Aspartokinase II/homoserine dehydrogenase II # BioGrid 4261101 411 # CATALYTIC ACTIVITY AK2H_ECOLI ATP + L-aspartate = ADP + 4-phospho-L- aspartate. # CATALYTIC ACTIVITY AK2H_ECOLI L-homoserine + NAD(P)(+) = L-aspartate 4- semialdehyde + NAD(P)H. # EcoGene EG10590 metL # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004072 aspartate kinase activity; IDA:EcoCyc. # GO_function GO:0004412 homoserine dehydrogenase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0050661 NADP binding; IEA:InterPro. # GO_process GO:0009086 methionine biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0009088 threonine biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0009089 lysine biosynthetic process via diaminopimelate; IDA:EcoCyc. # GO_process GO:0009090 homoserine biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.1160.10 -; 2. # Gene3D 3.40.50.720 -; 1. # IntAct P00562 3 # InterPro IPR001048 Asp/Glu/Uridylate_kinase # InterPro IPR001341 Asp_kinase_dom # InterPro IPR001342 HDH_cat # InterPro IPR005106 Asp/hSer_DH_NAD-bd # InterPro IPR011147 Bifunc_aspartokin/hSer_DH # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR018042 Aspartate_kinase_CS # InterPro IPR019811 HDH_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00260 Glycine, serine and threonine metabolism # KEGG_Pathway ko00270 Cysteine and methionine metabolism # KEGG_Pathway ko00300 Lysine biosynthesis # MISCELLANEOUS AK2H_ECOLI Aspartokinase I-homoserine dehydrogenase I and aspartokinase III also catalyze the same reaction(s). # Organism AK2H_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate step 1/4. # PATHWAY Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate step 1/3. # PATHWAY Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate step 3/3. # PATHWAY Amino-acid biosynthesis; L-threonine biosynthesis; L- threonine from L-aspartate step 1/5. # PATHWAY Amino-acid biosynthesis; L-threonine biosynthesis; L- threonine from L-aspartate step 3/5. # PATRIC 32123399 VBIEscCol129921_4060 # PIR S40883 DEECK2 # PIRSF PIRSF000727 ThrA # PROSITE PS00324 ASPARTOKINASE # PROSITE PS01042 HOMOSER_DHGENASE # Pfam PF00696 AA_kinase # Pfam PF00742 Homoserine_dh # Pfam PF03447 NAD_binding_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AK2H_ECOLI Aspartokinase # RecName AK2H_ECOLI Bifunctional aspartokinase/homoserine dehydrogenase 2 # RecName AK2H_ECOLI Homoserine dehydrogenase # RefSeq NP_418375 NC_000913.3 # RefSeq WP_000110772 NZ_LN832404.1 # SIMILARITY In the C-terminal section; belongs to the homoserine dehydrogenase family. {ECO 0000305}. # SIMILARITY In the N-terminal section; belongs to the aspartokinase family. {ECO 0000305}. # SUBUNIT AK2H_ECOLI Homotetramer. # SUPFAM SSF51735 SSF51735 # SUPFAM SSF53633 SSF53633 # TIGRFAMs TIGR00657 asp_kinases # UniPathway UPA00034 UER00015 # UniPathway UPA00050 UER00063 # UniPathway UPA00050 UER00461 # UniPathway UPA00051 UER00462 # UniPathway UPA00051 UER00465 # eggNOG COG0460 LUCA # eggNOG COG0527 LUCA # eggNOG ENOG4105CFH Bacteria BLAST swissprot:AK2H_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AK2H_ECOLI BioCyc ECOL316407:JW3911-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3911-MONOMER BioCyc EcoCyc:ASPKINIIHOMOSERDEHYDROGII-MONOMER http://biocyc.org/getid?id=EcoCyc:ASPKINIIHOMOSERDEHYDROGII-MONOMER BioCyc MetaCyc:ASPKINIIHOMOSERDEHYDROGII-MONOMER http://biocyc.org/getid?id=MetaCyc:ASPKINIIHOMOSERDEHYDROGII-MONOMER COG COG0460 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0460 COG COG0527 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0527 DIP DIP-10197N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10197N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.3 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.3 EC_number EC:2.7.2.4 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.2.4 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00305 http://www.ebi.ac.uk/ena/data/view/V00305 ENZYME 1.1.1.3 http://enzyme.expasy.org/EC/1.1.1.3 ENZYME 2.7.2.4 http://enzyme.expasy.org/EC/2.7.2.4 EchoBASE EB0585 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0585 EcoGene EG10590 http://www.ecogene.org/geneInfo.php?eg_id=EG10590 EnsemblBacteria AAC76922 http://www.ensemblgenomes.org/id/AAC76922 EnsemblBacteria AAC76922 http://www.ensemblgenomes.org/id/AAC76922 EnsemblBacteria BAE77370 http://www.ensemblgenomes.org/id/BAE77370 EnsemblBacteria BAE77370 http://www.ensemblgenomes.org/id/BAE77370 EnsemblBacteria BAE77370 http://www.ensemblgenomes.org/id/BAE77370 EnsemblBacteria b3940 http://www.ensemblgenomes.org/id/b3940 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004072 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004072 GO_function GO:0004412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004412 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0050661 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050661 GO_process GO:0009086 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009086 GO_process GO:0009088 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009088 GO_process GO:0009089 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009089 GO_process GO:0009090 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009090 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.1160.10 http://www.cathdb.info/version/latest/superfamily/3.40.1160.10 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 948433 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948433 HOGENOM HOG000271594 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000271594&db=HOGENOM6 InParanoid P00562 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00562 IntAct P00562 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00562* IntEnz 1.1.1.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.3 IntEnz 2.7.2.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.2.4 InterPro IPR001048 http://www.ebi.ac.uk/interpro/entry/IPR001048 InterPro IPR001341 http://www.ebi.ac.uk/interpro/entry/IPR001341 InterPro IPR001342 http://www.ebi.ac.uk/interpro/entry/IPR001342 InterPro IPR005106 http://www.ebi.ac.uk/interpro/entry/IPR005106 InterPro IPR011147 http://www.ebi.ac.uk/interpro/entry/IPR011147 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR018042 http://www.ebi.ac.uk/interpro/entry/IPR018042 InterPro IPR019811 http://www.ebi.ac.uk/interpro/entry/IPR019811 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3911 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3911 KEGG_Gene eco:b3940 http://www.genome.jp/dbget-bin/www_bget?eco:b3940 KEGG_Orthology KO:K12525 http://www.genome.jp/dbget-bin/www_bget?KO:K12525 KEGG_Pathway ko00260 http://www.genome.jp/kegg-bin/show_pathway?ko00260 KEGG_Pathway ko00270 http://www.genome.jp/kegg-bin/show_pathway?ko00270 KEGG_Pathway ko00300 http://www.genome.jp/kegg-bin/show_pathway?ko00300 KEGG_Reaction rn:R00480 http://www.genome.jp/dbget-bin/www_bget?rn:R00480 KEGG_Reaction rn:R01773 http://www.genome.jp/dbget-bin/www_bget?rn:R01773 KEGG_Reaction rn:R01775 http://www.genome.jp/dbget-bin/www_bget?rn:R01775 OMA TLQYPEF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TLQYPEF PROSITE PS00324 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00324 PROSITE PS01042 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01042 PSORT swissprot:AK2H_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AK2H_ECOLI PSORT-B swissprot:AK2H_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AK2H_ECOLI PSORT2 swissprot:AK2H_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AK2H_ECOLI Pfam PF00696 http://pfam.xfam.org/family/PF00696 Pfam PF00742 http://pfam.xfam.org/family/PF00742 Pfam PF03447 http://pfam.xfam.org/family/PF03447 Phobius swissprot:AK2H_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AK2H_ECOLI PhylomeDB P00562 http://phylomedb.org/?seqid=P00562 ProteinModelPortal P00562 http://www.proteinmodelportal.org/query/uniprot/P00562 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6298218 http://www.ncbi.nlm.nih.gov/pubmed/6298218 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418375 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418375 RefSeq WP_000110772 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000110772 SMR P00562 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00562 STRING 511145.b3940 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3940&targetmode=cogs STRING COG0460 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0460&targetmode=cogs STRING COG0527 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0527&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 SUPFAM SSF53633 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53633 TIGRFAMs TIGR00657 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00657 UniProtKB AK2H_ECOLI http://www.uniprot.org/uniprot/AK2H_ECOLI UniProtKB-AC P00562 http://www.uniprot.org/uniprot/P00562 charge swissprot:AK2H_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AK2H_ECOLI eggNOG COG0460 http://eggnogapi.embl.de/nog_data/html/tree/COG0460 eggNOG COG0527 http://eggnogapi.embl.de/nog_data/html/tree/COG0527 eggNOG ENOG4105CFH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CFH epestfind swissprot:AK2H_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AK2H_ECOLI garnier swissprot:AK2H_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AK2H_ECOLI helixturnhelix swissprot:AK2H_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AK2H_ECOLI hmoment swissprot:AK2H_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AK2H_ECOLI iep swissprot:AK2H_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AK2H_ECOLI inforesidue swissprot:AK2H_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AK2H_ECOLI octanol swissprot:AK2H_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AK2H_ECOLI pepcoil swissprot:AK2H_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AK2H_ECOLI pepdigest swissprot:AK2H_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AK2H_ECOLI pepinfo swissprot:AK2H_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AK2H_ECOLI pepnet swissprot:AK2H_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AK2H_ECOLI pepstats swissprot:AK2H_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AK2H_ECOLI pepwheel swissprot:AK2H_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AK2H_ECOLI pepwindow swissprot:AK2H_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AK2H_ECOLI sigcleave swissprot:AK2H_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AK2H_ECOLI ## Database ID URL or Descriptions # InterPro IPR016388 Put_partitioning_SopC # Organism YUAZ_ECOLI Escherichia coli (strain K12) # PIR C25783 BVECCF # PIRSF PIRSF003278 Partitioning_SopC # RecName YUAZ_ECOLI Uncharacterized protein YuaZ # RefSeq NP_061427 NC_002483.1 # RefSeq WP_010892535 NC_002483.1 # SEQUENCE CAUTION Sequence=CAA28297.1; Type=Frameshift; Positions=66; Evidence={ECO 0000305}; BLAST swissprot:YUAZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YUAZ_ECOLI DOI 10.1016/0022-2836(86)90459-6 http://dx.doi.org/10.1016/0022-2836(86)90459-6 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL X04619 http://www.ebi.ac.uk/ena/data/view/X04619 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1263598 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263598 InterPro IPR016388 http://www.ebi.ac.uk/interpro/entry/IPR016388 OMA MRLYACC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MRLYACC PSORT swissprot:YUAZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YUAZ_ECOLI PSORT-B swissprot:YUAZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YUAZ_ECOLI PSORT2 swissprot:YUAZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YUAZ_ECOLI Phobius swissprot:YUAZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YUAZ_ECOLI ProteinModelPortal P08868 http://www.proteinmodelportal.org/query/uniprot/P08868 PubMed 3029390 http://www.ncbi.nlm.nih.gov/pubmed/3029390 RefSeq NP_061427 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061427 RefSeq WP_010892535 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_010892535 UniProtKB YUAZ_ECOLI http://www.uniprot.org/uniprot/YUAZ_ECOLI UniProtKB-AC P08868 http://www.uniprot.org/uniprot/P08868 charge swissprot:YUAZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YUAZ_ECOLI epestfind swissprot:YUAZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YUAZ_ECOLI garnier swissprot:YUAZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YUAZ_ECOLI helixturnhelix swissprot:YUAZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YUAZ_ECOLI hmoment swissprot:YUAZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YUAZ_ECOLI iep swissprot:YUAZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YUAZ_ECOLI inforesidue swissprot:YUAZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YUAZ_ECOLI octanol swissprot:YUAZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YUAZ_ECOLI pepcoil swissprot:YUAZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YUAZ_ECOLI pepdigest swissprot:YUAZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YUAZ_ECOLI pepinfo swissprot:YUAZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YUAZ_ECOLI pepnet swissprot:YUAZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YUAZ_ECOLI pepstats swissprot:YUAZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YUAZ_ECOLI pepwheel swissprot:YUAZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YUAZ_ECOLI pepwindow swissprot:YUAZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YUAZ_ECOLI sigcleave swissprot:YUAZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YUAZ_ECOLI ## Database ID URL or Descriptions # AltName BEEE_ECOLI Putative protein BeeE from lambdoid prophage e14 region # BioGrid 4262853 9 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG14253 beeE # InterPro IPR006944 Phage/GTA_portal # Organism BEEE_ECOLI Escherichia coli (strain K12) # PATRIC 48661563 VBIEscCol107702_1150 # PIR D64860 D64860 # Pfam PF04860 Phage_portal # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Putative protein BeeE {ECO 0000305} # RefSeq WP_001350502 NZ_CP010440.1 # SIMILARITY Belongs to the phage portal family. {ECO 0000305}. # eggNOG COG4695 LUCA # eggNOG ENOG4105EFC Bacteria BLAST swissprot:BEEE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BEEE_ECOLI BioCyc ECOL316407:JW1137-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1137-MONOMER BioCyc EcoCyc:G6595-MONOMER http://biocyc.org/getid?id=EcoCyc:G6595-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4001 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4001 EcoGene EG14253 http://www.ecogene.org/geneInfo.php?eg_id=EG14253 EnsemblBacteria BAA35977 http://www.ensemblgenomes.org/id/BAA35977 EnsemblBacteria BAA35977 http://www.ensemblgenomes.org/id/BAA35977 EnsemblBacteria BAA35977 http://www.ensemblgenomes.org/id/BAA35977 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv HOGENOM HOG000202511 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000202511&db=HOGENOM6 InterPro IPR006944 http://www.ebi.ac.uk/interpro/entry/IPR006944 KEGG_Gene ecj:JW1137 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1137 OMA KTMQTTA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KTMQTTA PSORT swissprot:BEEE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BEEE_ECOLI PSORT-B swissprot:BEEE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BEEE_ECOLI PSORT2 swissprot:BEEE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BEEE_ECOLI Pfam PF04860 http://pfam.xfam.org/family/PF04860 Phobius swissprot:BEEE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BEEE_ECOLI ProteinModelPortal P75980 http://www.proteinmodelportal.org/query/uniprot/P75980 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001350502 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001350502 SMR P75980 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75980 STRING 316407.4062726 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.4062726&targetmode=cogs UniProtKB BEEE_ECOLI http://www.uniprot.org/uniprot/BEEE_ECOLI UniProtKB-AC P75980 http://www.uniprot.org/uniprot/P75980 charge swissprot:BEEE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BEEE_ECOLI eggNOG COG4695 http://eggnogapi.embl.de/nog_data/html/tree/COG4695 eggNOG ENOG4105EFC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EFC epestfind swissprot:BEEE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BEEE_ECOLI garnier swissprot:BEEE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BEEE_ECOLI helixturnhelix swissprot:BEEE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BEEE_ECOLI hmoment swissprot:BEEE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BEEE_ECOLI iep swissprot:BEEE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BEEE_ECOLI inforesidue swissprot:BEEE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BEEE_ECOLI octanol swissprot:BEEE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BEEE_ECOLI pepcoil swissprot:BEEE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BEEE_ECOLI pepdigest swissprot:BEEE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BEEE_ECOLI pepinfo swissprot:BEEE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BEEE_ECOLI pepnet swissprot:BEEE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BEEE_ECOLI pepstats swissprot:BEEE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BEEE_ECOLI pepwheel swissprot:BEEE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BEEE_ECOLI pepwindow swissprot:BEEE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BEEE_ECOLI sigcleave swissprot:BEEE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BEEE_ECOLI ## Database ID URL or Descriptions # BioGrid 4263281 17 # EcoGene EG13195 yfjI # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # IntAct P52124 2 # InterPro IPR025048 DUF3987 # Organism YFJI_ECOLI Escherichia coli (strain K12) # PATRIC 32120645 VBIEscCol129921_2721 # PIR T08637 T08637 # Pfam PF13148 DUF3987 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFJI_ECOLI Uncharacterized protein YfjI # RefSeq NP_417114 NC_000913.3 # RefSeq WP_000481742 NZ_LN832404.1 # eggNOG ENOG4108P8R Bacteria # eggNOG ENOG410YI8N LUCA BLAST swissprot:YFJI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFJI_ECOLI BioCyc ECOL316407:JW2605-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2605-MONOMER BioCyc EcoCyc:G7360-MONOMER http://biocyc.org/getid?id=EcoCyc:G7360-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36840 http://www.ebi.ac.uk/ena/data/view/U36840 EchoBASE EB2987 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2987 EcoGene EG13195 http://www.ecogene.org/geneInfo.php?eg_id=EG13195 EnsemblBacteria AAC75673 http://www.ensemblgenomes.org/id/AAC75673 EnsemblBacteria AAC75673 http://www.ensemblgenomes.org/id/AAC75673 EnsemblBacteria BAE76760 http://www.ensemblgenomes.org/id/BAE76760 EnsemblBacteria BAE76760 http://www.ensemblgenomes.org/id/BAE76760 EnsemblBacteria BAE76760 http://www.ensemblgenomes.org/id/BAE76760 EnsemblBacteria b2625 http://www.ensemblgenomes.org/id/b2625 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GeneID 944764 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944764 HOGENOM HOG000054865 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000054865&db=HOGENOM6 InParanoid P52124 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P52124 IntAct P52124 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P52124* InterPro IPR025048 http://www.ebi.ac.uk/interpro/entry/IPR025048 KEGG_Gene ecj:JW2605 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2605 KEGG_Gene eco:b2625 http://www.genome.jp/dbget-bin/www_bget?eco:b2625 OMA ATMSIAC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ATMSIAC PSORT swissprot:YFJI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFJI_ECOLI PSORT-B swissprot:YFJI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFJI_ECOLI PSORT2 swissprot:YFJI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFJI_ECOLI Pfam PF13148 http://pfam.xfam.org/family/PF13148 Phobius swissprot:YFJI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFJI_ECOLI ProteinModelPortal P52124 http://www.proteinmodelportal.org/query/uniprot/P52124 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417114 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417114 RefSeq WP_000481742 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000481742 SMR P52124 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P52124 STRING 511145.b2625 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2625&targetmode=cogs UniProtKB YFJI_ECOLI http://www.uniprot.org/uniprot/YFJI_ECOLI UniProtKB-AC P52124 http://www.uniprot.org/uniprot/P52124 charge swissprot:YFJI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFJI_ECOLI eggNOG ENOG4108P8R http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108P8R eggNOG ENOG410YI8N http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YI8N epestfind swissprot:YFJI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFJI_ECOLI garnier swissprot:YFJI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFJI_ECOLI helixturnhelix swissprot:YFJI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFJI_ECOLI hmoment swissprot:YFJI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFJI_ECOLI iep swissprot:YFJI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFJI_ECOLI inforesidue swissprot:YFJI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFJI_ECOLI octanol swissprot:YFJI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFJI_ECOLI pepcoil swissprot:YFJI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFJI_ECOLI pepdigest swissprot:YFJI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFJI_ECOLI pepinfo swissprot:YFJI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFJI_ECOLI pepnet swissprot:YFJI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFJI_ECOLI pepstats swissprot:YFJI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFJI_ECOLI pepwheel swissprot:YFJI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFJI_ECOLI pepwindow swissprot:YFJI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFJI_ECOLI sigcleave swissprot:YFJI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFJI_ECOLI ## Database ID URL or Descriptions # CAUTION There is no equivalent of this gene in strain K12 / MG1655. {ECO 0000305}. # FUNCTION INSB8_ECOLI Absolutely required for transposition of IS1. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # InterPro IPR005063 Transposase_27 # Organism INSB8_ECOLI Escherichia coli (strain K12) # PATRIC 48659219 VBIEscCol107702_0017 # Pfam PF03400 DDE_Tnp_IS1 # RecName INSB8_ECOLI Insertion element IS1 8 protein InsB # RefSeq WP_001119362 NZ_LN832404.1 # SIMILARITY Belongs to the transposase 27 family. {ECO 0000305}. # eggNOG COG1662 LUCA BLAST swissprot:INSB8_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSB8_ECOLI DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EnsemblBacteria BAA16125 http://www.ensemblgenomes.org/id/BAA16125 EnsemblBacteria BAA16125 http://www.ensemblgenomes.org/id/BAA16125 EnsemblBacteria BAA16125 http://www.ensemblgenomes.org/id/BAA16125 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GeneID 24944608 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24944608 InterPro IPR005063 http://www.ebi.ac.uk/interpro/entry/IPR005063 KEGG_Gene ecj:JW2285 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2285 PSORT swissprot:INSB8_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSB8_ECOLI PSORT-B swissprot:INSB8_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSB8_ECOLI PSORT2 swissprot:INSB8_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSB8_ECOLI Pfam PF03400 http://pfam.xfam.org/family/PF03400 Phobius swissprot:INSB8_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSB8_ECOLI PhylomeDB P0CF30 http://phylomedb.org/?seqid=P0CF30 ProteinModelPortal P0CF30 http://www.proteinmodelportal.org/query/uniprot/P0CF30 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 RefSeq WP_001119362 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001119362 STRING 511145.b3445 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3445&targetmode=cogs UniProtKB INSB8_ECOLI http://www.uniprot.org/uniprot/INSB8_ECOLI UniProtKB-AC P0CF30 http://www.uniprot.org/uniprot/P0CF30 charge swissprot:INSB8_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSB8_ECOLI eggNOG COG1662 http://eggnogapi.embl.de/nog_data/html/tree/COG1662 epestfind swissprot:INSB8_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSB8_ECOLI garnier swissprot:INSB8_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSB8_ECOLI helixturnhelix swissprot:INSB8_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSB8_ECOLI hmoment swissprot:INSB8_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSB8_ECOLI iep swissprot:INSB8_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSB8_ECOLI inforesidue swissprot:INSB8_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSB8_ECOLI octanol swissprot:INSB8_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSB8_ECOLI pepcoil swissprot:INSB8_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSB8_ECOLI pepdigest swissprot:INSB8_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSB8_ECOLI pepinfo swissprot:INSB8_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSB8_ECOLI pepnet swissprot:INSB8_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSB8_ECOLI pepstats swissprot:INSB8_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSB8_ECOLI pepwheel swissprot:INSB8_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSB8_ECOLI pepwindow swissprot:INSB8_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSB8_ECOLI sigcleave swissprot:INSB8_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSB8_ECOLI ## Database ID URL or Descriptions # AltName GMHA_ECOLI Sedoheptulose 7-phosphate isomerase # BRENDA 5.3.1.28 2026 # BioGrid 4263370 272 # CATALYTIC ACTIVITY D-sedoheptulose 7-phosphate = D-glycero-D- manno-heptose 7-phosphate. {ECO:0000269|PubMed 18056714}. # COFACTOR GMHA_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000250}; Note=Binds 1 zinc ion per subunit. {ECO 0000250}; # EcoGene EG13146 gmhA # FUNCTION GMHA_ECOLI Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate. {ECO 0000269|PubMed 11751812, ECO 0000269|PubMed 18056714}. # GO_component GO:0005737 cytoplasm; ISS:EcoCyc. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008968 D-sedoheptulose 7-phosphate isomerase activity; IDA:EcoCyc. # GO_function GO:0030246 carbohydrate binding; IEA:UniProtKB-HAMAP. # GO_process GO:0009244 lipopolysaccharide core region biosynthetic process; IMP:EcoCyc. # GO_process GO:2001061 D-glycero-D-manno-heptose 7-phosphate biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # HAMAP MF_00067 GmhA # InterPro IPR001347 SIS # InterPro IPR004515 Phosphoheptose_Isoase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # KEGG_Pathway ko00540 Lipopolysaccharide biosynthesis # MISCELLANEOUS GMHA_ECOLI The reaction produces a racemic mixture of D- glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D- manno-heptose 7-phosphate. # Organism GMHA_ECOLI Escherichia coli (strain K12) # PATHWAY Carbohydrate biosynthesis; D-glycero-D-manno-heptose 7- phosphate biosynthesis; D-glycero-alpha-D-manno-heptose 7- phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate step 1/1. # PATHWAY GMHA_ECOLI Bacterial outer membrane biogenesis; LPS core biosynthesis. # PATRIC 32115559 VBIEscCol129921_0224 # PDB 2I22 X-ray; 2.80 A; A/B/C/D=1-192 # PDB 2I2W X-ray; 1.95 A; A/B/C/D=1-192 # PIR G64746 G64746 # PROSITE PS51464 SIS # Pfam PF13580 SIS_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GMHA_ECOLI Phosphoheptose isomerase # RefSeq NP_414757 NC_000913.3 # RefSeq WP_000284050 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB08644.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the SIS family. GmhA subfamily. {ECO 0000305}. # SIMILARITY Contains 1 SIS domain. {ECO 0000305}. # SUBCELLULAR LOCATION GMHA_ECOLI Cytoplasm. # SUBUNIT Homotetramer. {ECO:0000269|PubMed 18056714}. # TIGRFAMs TIGR00441 gmhA # UniPathway UPA00041 UER00436 # eggNOG COG0279 LUCA # eggNOG ENOG4105F55 Bacteria BLAST swissprot:GMHA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GMHA_ECOLI BioCyc ECOL316407:JW0212-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0212-MONOMER BioCyc EcoCyc:G6106-MONOMER http://biocyc.org/getid?id=EcoCyc:G6106-MONOMER BioCyc MetaCyc:G6106-MONOMER http://biocyc.org/getid?id=MetaCyc:G6106-MONOMER COG COG0279 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0279 DIP DIP-48179N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48179N DOI 10.1016/0165-7992(95)90024-1 http://dx.doi.org/10.1016/0165-7992(95)90024-1 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.271.7.3608 http://dx.doi.org/10.1074/jbc.271.7.3608 DOI 10.1074/jbc.M706163200 http://dx.doi.org/10.1074/jbc.M706163200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.2.363-369.2002 http://dx.doi.org/10.1128/JB.184.2.363-369.2002 DOI 10.1146/annurev.biochem.71.110601.135414 http://dx.doi.org/10.1146/annurev.biochem.71.110601.135414 EC_number EC:5.3.1.28 http://www.genome.jp/dbget-bin/www_bget?EC:5.3.1.28 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D38582 http://www.ebi.ac.uk/ena/data/view/D38582 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U32590 http://www.ebi.ac.uk/ena/data/view/U32590 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 ENZYME 5.3.1.28 http://enzyme.expasy.org/EC/5.3.1.28 EchoBASE EB2940 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2940 EcoGene EG13146 http://www.ecogene.org/geneInfo.php?eg_id=EG13146 EnsemblBacteria AAC73326 http://www.ensemblgenomes.org/id/AAC73326 EnsemblBacteria AAC73326 http://www.ensemblgenomes.org/id/AAC73326 EnsemblBacteria BAA77892 http://www.ensemblgenomes.org/id/BAA77892 EnsemblBacteria BAA77892 http://www.ensemblgenomes.org/id/BAA77892 EnsemblBacteria BAA77892 http://www.ensemblgenomes.org/id/BAA77892 EnsemblBacteria b0222 http://www.ensemblgenomes.org/id/b0222 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0008968 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008968 GO_function GO:0030246 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030246 GO_process GO:0009244 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009244 GO_process GO:2001061 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2001061 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 949134 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949134 HAMAP MF_00067 http://hamap.expasy.org/unirule/MF_00067 HOGENOM HOG000237571 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000237571&db=HOGENOM6 InParanoid P63224 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P63224 IntEnz 5.3.1.28 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.3.1.28 InterPro IPR001347 http://www.ebi.ac.uk/interpro/entry/IPR001347 InterPro IPR004515 http://www.ebi.ac.uk/interpro/entry/IPR004515 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Gene ecj:JW0212 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0212 KEGG_Gene eco:b0222 http://www.genome.jp/dbget-bin/www_bget?eco:b0222 KEGG_Orthology KO:K03271 http://www.genome.jp/dbget-bin/www_bget?KO:K03271 KEGG_Pathway ko00540 http://www.genome.jp/kegg-bin/show_pathway?ko00540 KEGG_Reaction rn:R05645 http://www.genome.jp/dbget-bin/www_bget?rn:R05645 KEGG_Reaction rn:R09768 http://www.genome.jp/dbget-bin/www_bget?rn:R09768 KEGG_Reaction rn:R09769 http://www.genome.jp/dbget-bin/www_bget?rn:R09769 OMA EMHILMI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EMHILMI PDB 2I22 http://www.ebi.ac.uk/pdbe-srv/view/entry/2I22 PDB 2I2W http://www.ebi.ac.uk/pdbe-srv/view/entry/2I2W PDBsum 2I22 http://www.ebi.ac.uk/pdbsum/2I22 PDBsum 2I2W http://www.ebi.ac.uk/pdbsum/2I2W PROSITE PS51464 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51464 PSORT swissprot:GMHA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GMHA_ECOLI PSORT-B swissprot:GMHA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GMHA_ECOLI PSORT2 swissprot:GMHA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GMHA_ECOLI Pfam PF13580 http://pfam.xfam.org/family/PF13580 Phobius swissprot:GMHA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GMHA_ECOLI PhylomeDB P63224 http://phylomedb.org/?seqid=P63224 ProteinModelPortal P63224 http://www.proteinmodelportal.org/query/uniprot/P63224 PubMed 11751812 http://www.ncbi.nlm.nih.gov/pubmed/11751812 PubMed 12045108 http://www.ncbi.nlm.nih.gov/pubmed/12045108 PubMed 12101286 http://www.ncbi.nlm.nih.gov/pubmed/12101286 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18056714 http://www.ncbi.nlm.nih.gov/pubmed/18056714 PubMed 7596361 http://www.ncbi.nlm.nih.gov/pubmed/7596361 PubMed 8631969 http://www.ncbi.nlm.nih.gov/pubmed/8631969 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414757 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414757 RefSeq WP_000284050 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000284050 SMR P63224 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P63224 STRING 511145.b0222 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0222&targetmode=cogs STRING COG0279 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0279&targetmode=cogs TIGRFAMs TIGR00441 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00441 UniProtKB GMHA_ECOLI http://www.uniprot.org/uniprot/GMHA_ECOLI UniProtKB-AC P63224 http://www.uniprot.org/uniprot/P63224 charge swissprot:GMHA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GMHA_ECOLI eggNOG COG0279 http://eggnogapi.embl.de/nog_data/html/tree/COG0279 eggNOG ENOG4105F55 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F55 epestfind swissprot:GMHA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GMHA_ECOLI garnier swissprot:GMHA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GMHA_ECOLI helixturnhelix swissprot:GMHA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GMHA_ECOLI hmoment swissprot:GMHA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GMHA_ECOLI iep swissprot:GMHA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GMHA_ECOLI inforesidue swissprot:GMHA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GMHA_ECOLI octanol swissprot:GMHA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GMHA_ECOLI pepcoil swissprot:GMHA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GMHA_ECOLI pepdigest swissprot:GMHA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GMHA_ECOLI pepinfo swissprot:GMHA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GMHA_ECOLI pepnet swissprot:GMHA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GMHA_ECOLI pepstats swissprot:GMHA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GMHA_ECOLI pepwheel swissprot:GMHA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GMHA_ECOLI pepwindow swissprot:GMHA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GMHA_ECOLI sigcleave swissprot:GMHA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GMHA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260313 11 # EcoGene EG13494 yeaH # HAMAP MF_01232 UPF0229 # InterPro IPR006698 UPF0229 # Organism YEAH_ECOLI Escherichia coli (strain K12) # PATRIC 32118879 VBIEscCol129921_1857 # PIR H64938 H64938 # Pfam PF04285 DUF444 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEAH_ECOLI UPF0229 protein YeaH # RefSeq NP_416298 NC_000913.3 # RefSeq WP_000219687 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0229 family. {ECO 0000305}. # eggNOG COG2718 LUCA # eggNOG ENOG4106AKX Bacteria BLAST swissprot:YEAH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEAH_ECOLI BioCyc ECOL316407:JW1773-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1773-MONOMER BioCyc EcoCyc:G6970-MONOMER http://biocyc.org/getid?id=EcoCyc:G6970-MONOMER COG COG2718 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2718 DIP DIP-11787N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11787N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3267 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3267 EcoGene EG13494 http://www.ecogene.org/geneInfo.php?eg_id=EG13494 EnsemblBacteria AAC74854 http://www.ensemblgenomes.org/id/AAC74854 EnsemblBacteria AAC74854 http://www.ensemblgenomes.org/id/AAC74854 EnsemblBacteria BAA15585 http://www.ensemblgenomes.org/id/BAA15585 EnsemblBacteria BAA15585 http://www.ensemblgenomes.org/id/BAA15585 EnsemblBacteria BAA15585 http://www.ensemblgenomes.org/id/BAA15585 EnsemblBacteria b1784 http://www.ensemblgenomes.org/id/b1784 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946296 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946296 HAMAP MF_01232 http://hamap.expasy.org/unirule/MF_01232 HOGENOM HOG000260091 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260091&db=HOGENOM6 InParanoid P76235 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76235 IntAct P76235 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76235* InterPro IPR006698 http://www.ebi.ac.uk/interpro/entry/IPR006698 KEGG_Gene ecj:JW1773 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1773 KEGG_Gene eco:b1784 http://www.genome.jp/dbget-bin/www_bget?eco:b1784 KEGG_Orthology KO:K09786 http://www.genome.jp/dbget-bin/www_bget?KO:K09786 OMA QYFAYIE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QYFAYIE PSORT swissprot:YEAH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEAH_ECOLI PSORT-B swissprot:YEAH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEAH_ECOLI PSORT2 swissprot:YEAH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEAH_ECOLI Pfam PF04285 http://pfam.xfam.org/family/PF04285 Phobius swissprot:YEAH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEAH_ECOLI PhylomeDB P76235 http://phylomedb.org/?seqid=P76235 ProteinModelPortal P76235 http://www.proteinmodelportal.org/query/uniprot/P76235 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416298 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416298 RefSeq WP_000219687 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000219687 SMR P76235 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76235 STRING 511145.b1784 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1784&targetmode=cogs STRING COG2718 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2718&targetmode=cogs UniProtKB YEAH_ECOLI http://www.uniprot.org/uniprot/YEAH_ECOLI UniProtKB-AC P76235 http://www.uniprot.org/uniprot/P76235 charge swissprot:YEAH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEAH_ECOLI eggNOG COG2718 http://eggnogapi.embl.de/nog_data/html/tree/COG2718 eggNOG ENOG4106AKX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106AKX epestfind swissprot:YEAH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEAH_ECOLI garnier swissprot:YEAH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEAH_ECOLI helixturnhelix swissprot:YEAH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEAH_ECOLI hmoment swissprot:YEAH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEAH_ECOLI iep swissprot:YEAH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEAH_ECOLI inforesidue swissprot:YEAH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEAH_ECOLI octanol swissprot:YEAH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEAH_ECOLI pepcoil swissprot:YEAH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEAH_ECOLI pepdigest swissprot:YEAH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEAH_ECOLI pepinfo swissprot:YEAH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEAH_ECOLI pepnet swissprot:YEAH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEAH_ECOLI pepstats swissprot:YEAH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEAH_ECOLI pepwheel swissprot:YEAH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEAH_ECOLI pepwindow swissprot:YEAH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEAH_ECOLI sigcleave swissprot:YEAH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEAH_ECOLI ## Database ID URL or Descriptions # AltName Exonuclease V subunit RecC {ECO:0000255|HAMAP-Rule MF_01486} # AltName RECC_ECOLI Exodeoxyribonuclease V 125 kDa polypeptide # AltName RECC_ECOLI Exodeoxyribonuclease V gamma chain # BRENDA 3.1.11 2026 # BioGrid 4261821 369 # CATALYTIC ACTIVITY Exonucleolytic cleavage (in the presence of ATP) in either 5'- to 3'- or 3'- to 5'-direction to yield 5'- phosphooligonucleotides. {ECO:0000255|HAMAP-Rule MF_01486}. # DISRUPTION PHENOTYPE RECC_ECOLI Decreased degradation of DNA with free ends that is unable to undergo homologous recombination, which can fortuitously lead to more efficient viral infection (PubMed 4562392, PubMed 123277). Cells are deficient in DNA recombination repair and have increased sensitivity to UV light. The cultures have many inviable cells. {ECO 0000269|PubMed 123277, ECO 0000269|PubMed 4562392, ECO 0000269|PubMed 6389498}. # DOMAIN RECC_ECOLI The holoenzyme may undergo conformational shifts upon DNA binding the nuclease domain of RecB may swing away from the DNA exit tunnel in RecC. When Chi DNA binds to the RecC tunnel, the nuclease domain may then swing back to its original position (that seen in crystal structures), allowing it to nick the DNA 3' of the Chi site and then rotate to load RecA. At high Mg(2+) the nuclease domain may swing back more frequently, explaining differences seen in assays performed at high Mg(2+). {ECO 0000269|PubMed 25073102}. # ENZYME REGULATION RECC_ECOLI After reacting with DNA bearing a Chi site the holoenzyme is disassembled and loses exonuclease activity, DNA unwinding and Chi-directed DNA cleavage; RecB remains complexed with ssDNA, which may prevent holoenzyme reassembly (PubMed 10197988). High levels of Mg(2+) (13 mM MgCl(2+)) or incubation with DNase allow holoenyzme reassembly, suggesting it is DNA bound to RecB that prevents reassembly (PubMed 10197988). {ECO 0000269|PubMed 10197988, ECO 0000269|PubMed 1535156}. # EcoGene EG10825 recC # FUNCTION RECC_ECOLI A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a rapid (>1 kb/second) and highly processive (>30 kb) ATP-dependent bidirectional helicase. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator, 5'-GCTGGTGG-3') sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to Chi site, by nicking one strand or switching the strand degraded (depending on the reaction conditions). The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang which facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination (PubMed 4562392, PubMed 4552016, PubMed 123277). In the holoenzyme this subunit almost certainly recognizes the wild- type Chi sequence, when added to isolated RecB increases its ATP- dependent helicase processivity. The RecBC complex requires the RecD subunit for nuclease activity, but can translocate along ssDNA in both directions. {ECO 0000269|PubMed 10197988, ECO 0000269|PubMed 10884344, ECO 0000269|PubMed 123277, ECO 0000269|PubMed 12815437, ECO 0000269|PubMed 12815438, ECO 0000269|PubMed 1535156, ECO 0000269|PubMed 16041061, ECO 0000269|PubMed 1618858, ECO 0000269|PubMed 20852646, ECO 0000269|PubMed 23851395, ECO 0000269|PubMed 4268693, ECO 0000269|PubMed 4552016, ECO 0000269|PubMed 4562392, ECO 0000269|PubMed 7608206, ECO 0000269|PubMed 9192629, ECO 0000269|PubMed 9230304, ECO 0000269|PubMed 9448271, ECO 0000269|PubMed 9790841}. # GO_component GO:0009338 exodeoxyribonuclease V complex; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0004003 ATP-dependent DNA helicase activity; IDA:EcoCyc. # GO_function GO:0004519 endonuclease activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008854 exodeoxyribonuclease V activity; IDA:EcoCyc. # GO_process GO:0000724 double-strand break repair via homologous recombination; IEA:UniProtKB-HAMAP. # GO_process GO:0006302 double-strand break repair; IDA:EcoCyc. # GO_process GO:0006310 DNA recombination; IMP:EcoCyc. # GO_process GO:0044355 clearance of foreign intracellular DNA; IMP:UniProtKB. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004386 helicase activity # GOslim_function GO:0004518 nuclease activity # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # Gene3D 1.10.10.160 -; 1. # Gene3D 3.40.50.300 -; 2. # HAMAP MF_01486 RecC # IntAct P07648 3 # InterPro IPR006697 RecC # InterPro IPR011335 Restrct_endonuc-II-like # InterPro IPR013986 DExx_box_DNA_helicase_dom # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko03440 Homologous recombination # Organism RECC_ECOLI Escherichia coli (strain K12) # PATRIC 32121062 VBIEscCol129921_2920 # PDB 1W36 X-ray; 3.10 A; C/F=1-1122 # PDB 3K70 X-ray; 3.59 A; C/F=1-1122 # PDB 5LD2 EM; 3.83 A; C=1-1122 # PIR A24137 NCECXV # PIRSF PIRSF000980 RecC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RecBCD enzyme subunit RecC {ECO:0000255|HAMAP-Rule MF_01486} # RefSeq NP_417299 NC_000913.3 # RefSeq WP_000946938 NZ_LN832404.1 # SIMILARITY Belongs to the RecC family. {ECO:0000255|HAMAP- Rule MF_01486}. # SUBUNIT RECC_ECOLI Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding. Interacts with YgbT (Cas1) (PubMed 21219465). {ECO 0000255|HAMAP-Rule MF_01486, ECO 0000269|PubMed 15538360, ECO 0000269|PubMed 1618858, ECO 0000269|PubMed 18668125, ECO 0000269|PubMed 21219465, ECO 0000269|PubMed 3526335, ECO 0000269|PubMed 4552016, ECO 0000269|PubMed 9448271}. # SUPFAM SSF52540 SSF52540; 2 # SUPFAM SSF52980 SSF52980 # TIGRFAMs TIGR01450 recC # eggNOG COG1330 LUCA # eggNOG ENOG4105DSY Bacteria BLAST swissprot:RECC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RECC_ECOLI BioCyc ECOL316407:JW2790-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2790-MONOMER BioCyc EcoCyc:EG10825-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10825-MONOMER BioCyc MetaCyc:EG10825-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10825-MONOMER COG COG1330 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1330 DIP DIP-10650N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10650N DOI 10.1006/jmbi.1998.2127 http://dx.doi.org/10.1006/jmbi.1998.2127 DOI 10.1006/jmbi.2000.3861 http://dx.doi.org/10.1006/jmbi.2000.3861 DOI 10.1016/S0092-8674(00)80315-3 http://dx.doi.org/10.1016/S0092-8674(00)80315-3 DOI 10.1016/j.jmb.2014.07.017 http://dx.doi.org/10.1016/j.jmb.2014.07.017 DOI 10.1038/emboj.2008.144 http://dx.doi.org/10.1038/emboj.2008.144 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature01673 http://dx.doi.org/10.1038/nature01673 DOI 10.1038/nature01674 http://dx.doi.org/10.1038/nature01674 DOI 10.1038/nature02988 http://dx.doi.org/10.1038/nature02988 DOI 10.1038/nature12333 http://dx.doi.org/10.1038/nature12333 DOI 10.1038/nsmb.1901 http://dx.doi.org/10.1038/nsmb.1901 DOI 10.1073/pnas.1206076109 http://dx.doi.org/10.1073/pnas.1206076109 DOI 10.1073/pnas.83.15.5558 http://dx.doi.org/10.1073/pnas.83.15.5558 DOI 10.1073/pnas.89.12.5226 http://dx.doi.org/10.1073/pnas.89.12.5226 DOI 10.1073/pnas.94.13.6706 http://dx.doi.org/10.1073/pnas.94.13.6706 DOI 10.1073/pnas.95.3.981 http://dx.doi.org/10.1073/pnas.95.3.981 DOI 10.1074/jbc.270.27.16360 http://dx.doi.org/10.1074/jbc.270.27.16360 DOI 10.1074/jbc.M505520200 http://dx.doi.org/10.1074/jbc.M505520200 DOI 10.1093/nar/14.11.4437 http://dx.doi.org/10.1093/nar/14.11.4437 DOI 10.1093/nar/14.19.7695 http://dx.doi.org/10.1093/nar/14.19.7695 DOI 10.1101/gad.13.7.890 http://dx.doi.org/10.1101/gad.13.7.890 DOI 10.1101/gad.1605807 http://dx.doi.org/10.1101/gad.1605807 DOI 10.1111/j.1365-2958.2010.07465.x http://dx.doi.org/10.1111/j.1365-2958.2010.07465.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/MMBR.00020-08 http://dx.doi.org/10.1128/MMBR.00020-08 DOI 10.1128/MMBR.05026-11 http://dx.doi.org/10.1128/MMBR.05026-11 EC_number EC:3.1.11.5 {ECO:0000255|HAMAP-Rule:MF_01486} http://www.genome.jp/dbget-bin/www_bget?EC:3.1.11.5 {ECO:0000255|HAMAP-Rule:MF_01486} EMBL AF176618 http://www.ebi.ac.uk/ena/data/view/AF176618 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 EMBL X03966 http://www.ebi.ac.uk/ena/data/view/X03966 EMBL X06227 http://www.ebi.ac.uk/ena/data/view/X06227 ENZYME 3.1.11.5 {ECO:0000255|HAMAP-Rule:MF_01486} http://enzyme.expasy.org/EC/3.1.11.5 {ECO:0000255|HAMAP-Rule:MF_01486} EchoBASE EB0818 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0818 EcoGene EG10825 http://www.ecogene.org/geneInfo.php?eg_id=EG10825 EnsemblBacteria AAC75861 http://www.ensemblgenomes.org/id/AAC75861 EnsemblBacteria AAC75861 http://www.ensemblgenomes.org/id/AAC75861 EnsemblBacteria BAE76891 http://www.ensemblgenomes.org/id/BAE76891 EnsemblBacteria BAE76891 http://www.ensemblgenomes.org/id/BAE76891 EnsemblBacteria BAE76891 http://www.ensemblgenomes.org/id/BAE76891 EnsemblBacteria b2822 http://www.ensemblgenomes.org/id/b2822 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009338 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009338 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004003 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004003 GO_function GO:0004519 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004519 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008854 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008854 GO_process GO:0000724 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000724 GO_process GO:0006302 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006302 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0044355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044355 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004386 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 1.10.10.160 http://www.cathdb.info/version/latest/superfamily/1.10.10.160 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947294 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947294 HAMAP MF_01486 http://hamap.expasy.org/unirule/MF_01486 HOGENOM HOG000258319 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000258319&db=HOGENOM6 InParanoid P07648 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P07648 IntAct P07648 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P07648* IntEnz 3.1.11.5 {ECO:0000255|HAMAP-Rule:MF_01486} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.11.5 {ECO:0000255|HAMAP-Rule:MF_01486} InterPro IPR006697 http://www.ebi.ac.uk/interpro/entry/IPR006697 InterPro IPR011335 http://www.ebi.ac.uk/interpro/entry/IPR011335 InterPro IPR013986 http://www.ebi.ac.uk/interpro/entry/IPR013986 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW2790 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2790 KEGG_Gene eco:b2822 http://www.genome.jp/dbget-bin/www_bget?eco:b2822 KEGG_Orthology KO:K03583 http://www.genome.jp/dbget-bin/www_bget?KO:K03583 KEGG_Pathway ko03440 http://www.genome.jp/kegg-bin/show_pathway?ko03440 MINT MINT-1318941 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1318941 OMA SWMRRYP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SWMRRYP PDB 1W36 http://www.ebi.ac.uk/pdbe-srv/view/entry/1W36 PDB 3K70 http://www.ebi.ac.uk/pdbe-srv/view/entry/3K70 PDB 5LD2 http://www.ebi.ac.uk/pdbe-srv/view/entry/5LD2 PDBsum 1W36 http://www.ebi.ac.uk/pdbsum/1W36 PDBsum 3K70 http://www.ebi.ac.uk/pdbsum/3K70 PDBsum 5LD2 http://www.ebi.ac.uk/pdbsum/5LD2 PSORT swissprot:RECC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RECC_ECOLI PSORT-B swissprot:RECC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RECC_ECOLI PSORT2 swissprot:RECC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RECC_ECOLI Phobius swissprot:RECC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RECC_ECOLI PhylomeDB P07648 http://phylomedb.org/?seqid=P07648 ProteinModelPortal P07648 http://www.proteinmodelportal.org/query/uniprot/P07648 PubMed 10197988 http://www.ncbi.nlm.nih.gov/pubmed/10197988 PubMed 10884344 http://www.ncbi.nlm.nih.gov/pubmed/10884344 PubMed 123277 http://www.ncbi.nlm.nih.gov/pubmed/123277 PubMed 12815437 http://www.ncbi.nlm.nih.gov/pubmed/12815437 PubMed 12815438 http://www.ncbi.nlm.nih.gov/pubmed/12815438 PubMed 1535156 http://www.ncbi.nlm.nih.gov/pubmed/1535156 PubMed 15538360 http://www.ncbi.nlm.nih.gov/pubmed/15538360 PubMed 16041061 http://www.ncbi.nlm.nih.gov/pubmed/16041061 PubMed 1618858 http://www.ncbi.nlm.nih.gov/pubmed/1618858 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18079176 http://www.ncbi.nlm.nih.gov/pubmed/18079176 PubMed 18668125 http://www.ncbi.nlm.nih.gov/pubmed/18668125 PubMed 19052323 http://www.ncbi.nlm.nih.gov/pubmed/19052323 PubMed 20852646 http://www.ncbi.nlm.nih.gov/pubmed/20852646 PubMed 21219465 http://www.ncbi.nlm.nih.gov/pubmed/21219465 PubMed 22603794 http://www.ncbi.nlm.nih.gov/pubmed/22603794 PubMed 22688812 http://www.ncbi.nlm.nih.gov/pubmed/22688812 PubMed 23851395 http://www.ncbi.nlm.nih.gov/pubmed/23851395 PubMed 25073102 http://www.ncbi.nlm.nih.gov/pubmed/25073102 PubMed 3520484 http://www.ncbi.nlm.nih.gov/pubmed/3520484 PubMed 3526335 http://www.ncbi.nlm.nih.gov/pubmed/3526335 PubMed 3534791 http://www.ncbi.nlm.nih.gov/pubmed/3534791 PubMed 4268693 http://www.ncbi.nlm.nih.gov/pubmed/4268693 PubMed 4552016 http://www.ncbi.nlm.nih.gov/pubmed/4552016 PubMed 4562392 http://www.ncbi.nlm.nih.gov/pubmed/4562392 PubMed 6389498 http://www.ncbi.nlm.nih.gov/pubmed/6389498 PubMed 7608206 http://www.ncbi.nlm.nih.gov/pubmed/7608206 PubMed 9192629 http://www.ncbi.nlm.nih.gov/pubmed/9192629 PubMed 9230304 http://www.ncbi.nlm.nih.gov/pubmed/9230304 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9448271 http://www.ncbi.nlm.nih.gov/pubmed/9448271 PubMed 9790841 http://www.ncbi.nlm.nih.gov/pubmed/9790841 RefSeq NP_417299 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417299 RefSeq WP_000946938 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000946938 SMR P07648 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P07648 STRING 511145.b2822 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2822&targetmode=cogs STRING COG1330 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1330&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SUPFAM SSF52980 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52980 TIGRFAMs TIGR01450 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01450 UniProtKB RECC_ECOLI http://www.uniprot.org/uniprot/RECC_ECOLI UniProtKB-AC P07648 http://www.uniprot.org/uniprot/P07648 charge swissprot:RECC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RECC_ECOLI eggNOG COG1330 http://eggnogapi.embl.de/nog_data/html/tree/COG1330 eggNOG ENOG4105DSY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DSY epestfind swissprot:RECC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RECC_ECOLI garnier swissprot:RECC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RECC_ECOLI helixturnhelix swissprot:RECC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RECC_ECOLI hmoment swissprot:RECC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RECC_ECOLI iep swissprot:RECC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RECC_ECOLI inforesidue swissprot:RECC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RECC_ECOLI octanol swissprot:RECC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RECC_ECOLI pepcoil swissprot:RECC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RECC_ECOLI pepdigest swissprot:RECC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RECC_ECOLI pepinfo swissprot:RECC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RECC_ECOLI pepnet swissprot:RECC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RECC_ECOLI pepstats swissprot:RECC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RECC_ECOLI pepwheel swissprot:RECC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RECC_ECOLI pepwindow swissprot:RECC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RECC_ECOLI sigcleave swissprot:RECC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RECC_ECOLI ## Database ID URL or Descriptions # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # Organism CYSX_ECOLI Escherichia coli (strain K12) # PIR B34563 B34563 # RecName CYSX_ECOLI Putative uncharacterized protein CysX BLAST swissprot:CYSX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CYSX_ECOLI DOI 10.1016/0006-291X(90)90615-T http://dx.doi.org/10.1016/0006-291X(90)90615-T EMBL M34333 http://www.ebi.ac.uk/ena/data/view/M34333 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv PSORT swissprot:CYSX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CYSX_ECOLI PSORT-B swissprot:CYSX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CYSX_ECOLI PSORT2 swissprot:CYSX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CYSX_ECOLI Phobius swissprot:CYSX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CYSX_ECOLI ProteinModelPortal P20343 http://www.proteinmodelportal.org/query/uniprot/P20343 PubMed 2108679 http://www.ncbi.nlm.nih.gov/pubmed/2108679 SMR P20343 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P20343 UniProtKB CYSX_ECOLI http://www.uniprot.org/uniprot/CYSX_ECOLI UniProtKB-AC P20343 http://www.uniprot.org/uniprot/P20343 charge swissprot:CYSX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CYSX_ECOLI epestfind swissprot:CYSX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CYSX_ECOLI garnier swissprot:CYSX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CYSX_ECOLI helixturnhelix swissprot:CYSX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CYSX_ECOLI hmoment swissprot:CYSX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CYSX_ECOLI iep swissprot:CYSX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CYSX_ECOLI inforesidue swissprot:CYSX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CYSX_ECOLI octanol swissprot:CYSX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CYSX_ECOLI pepcoil swissprot:CYSX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CYSX_ECOLI pepdigest swissprot:CYSX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CYSX_ECOLI pepinfo swissprot:CYSX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CYSX_ECOLI pepnet swissprot:CYSX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CYSX_ECOLI pepstats swissprot:CYSX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CYSX_ECOLI pepwheel swissprot:CYSX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CYSX_ECOLI pepwindow swissprot:CYSX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CYSX_ECOLI sigcleave swissprot:CYSX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CYSX_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES THRC_ECOLI Kinetic parameters KM=0.5 mM for O-phospho-L-homoserine {ECO 0000269|PubMed 7907888}; Vmax=9.3 umol/min/mg enzyme {ECO 0000269|PubMed 7907888}; # BioGrid 4261935 235 # CATALYTIC ACTIVITY O-phospho-L-homoserine + H(2)O = L-threonine + phosphate. {ECO:0000269|PubMed 7907888}. # COFACTOR THRC_ECOLI Name=pyridoxal 5'-phosphate; Xref=ChEBI CHEBI 597326; Evidence={ECO 0000269|PubMed 7907888}; # ENZYME REGULATION Is competitively inhibited by L-threo-3- hydroxyhomoserine phosphate. {ECO:0000269|PubMed 7907888}. # EcoGene EG11000 thrC # FUNCTION THRC_ECOLI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. To a lesser extent, is able to slowly catalyze the deamination of L-threonine into alpha-ketobutyrate and that of L- serine and 3-chloroalanine into pyruvate. Is also able to rapidly convert vinylglycine to threonine, which proves that the pyridoxal p-quinonoid of vinylglycine is an intermediate in the TS reaction. {ECO 0000269|PubMed 7907888}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004795 threonine synthase activity; IDA:EcoCyc. # GO_function GO:0030170 pyridoxal phosphate binding; IBA:GO_Central. # GO_process GO:0009088 threonine biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.90.1380.10 -; 1. # IntAct P00934 2 # InterPro IPR000634 Ser/Thr_deHydtase_PyrdxlP-BS # InterPro IPR001926 TrpB-like_PLP-dep # InterPro IPR004450 Thr_synthase-like # InterPro IPR029144 Thr_synth_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00260 Glycine, serine and threonine metabolism # KEGG_Pathway ko00750 Vitamin B6 metabolism # Organism THRC_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-threonine biosynthesis; L- threonine from L-aspartate step 5/5. # PATRIC 32115103 VBIEscCol129921_0003 # PDB 1VB3 X-ray; 2.20 A; A=1-428 # PIR A01157 SYECR # PROSITE PS00165 DEHYDRATASE_SER_THR # Pfam PF00291 PALP # Pfam PF14821 Thr_synth_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName THRC_ECOLI Threonine synthase # RefSeq NP_414545 NC_000913.3 # RefSeq WP_000781074 NZ_LN832404.1 # SIMILARITY Belongs to the threonine synthase family. {ECO 0000305}. # SUPFAM SSF53686 SSF53686 # TIGRFAMs TIGR00260 thrC # UniPathway UPA00050 UER00065 # eggNOG COG0498 LUCA # eggNOG ENOG4105D98 Bacteria BLAST swissprot:THRC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:THRC_ECOLI BioCyc ECOL316407:JW0003-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0003-MONOMER BioCyc EcoCyc:THRESYN-MONOMER http://biocyc.org/getid?id=EcoCyc:THRESYN-MONOMER BioCyc MetaCyc:THRESYN-MONOMER http://biocyc.org/getid?id=MetaCyc:THRESYN-MONOMER COG COG0498 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0498 DIP DIP-10993N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10993N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1998.1726 http://dx.doi.org/10.1006/jmbi.1998.1726 DOI 10.1021/bi00177a035 http://dx.doi.org/10.1021/bi00177a035 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/11.21.7331 http://dx.doi.org/10.1093/nar/11.21.7331 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.3.1 http://www.genome.jp/dbget-bin/www_bget?EC:4.2.3.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01706 http://www.ebi.ac.uk/ena/data/view/J01706 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 4.2.3.1 http://enzyme.expasy.org/EC/4.2.3.1 EchoBASE EB0993 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0993 EcoGene EG11000 http://www.ecogene.org/geneInfo.php?eg_id=EG11000 EnsemblBacteria AAC73115 http://www.ensemblgenomes.org/id/AAC73115 EnsemblBacteria AAC73115 http://www.ensemblgenomes.org/id/AAC73115 EnsemblBacteria BAB96581 http://www.ensemblgenomes.org/id/BAB96581 EnsemblBacteria BAB96581 http://www.ensemblgenomes.org/id/BAB96581 EnsemblBacteria BAB96581 http://www.ensemblgenomes.org/id/BAB96581 EnsemblBacteria b0004 http://www.ensemblgenomes.org/id/b0004 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004795 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004795 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_process GO:0009088 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009088 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.90.1380.10 http://www.cathdb.info/version/latest/superfamily/3.90.1380.10 GeneID 945198 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945198 HOGENOM HOG000230743 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230743&db=HOGENOM6 InParanoid P00934 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00934 IntAct P00934 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00934* IntEnz 4.2.3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.3.1 InterPro IPR000634 http://www.ebi.ac.uk/interpro/entry/IPR000634 InterPro IPR001926 http://www.ebi.ac.uk/interpro/entry/IPR001926 InterPro IPR004450 http://www.ebi.ac.uk/interpro/entry/IPR004450 InterPro IPR029144 http://www.ebi.ac.uk/interpro/entry/IPR029144 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0003 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0003 KEGG_Gene eco:b0004 http://www.genome.jp/dbget-bin/www_bget?eco:b0004 KEGG_Orthology KO:K01733 http://www.genome.jp/dbget-bin/www_bget?KO:K01733 KEGG_Pathway ko00260 http://www.genome.jp/kegg-bin/show_pathway?ko00260 KEGG_Pathway ko00750 http://www.genome.jp/kegg-bin/show_pathway?ko00750 KEGG_Reaction rn:R01466 http://www.genome.jp/dbget-bin/www_bget?rn:R01466 KEGG_Reaction rn:R05086 http://www.genome.jp/dbget-bin/www_bget?rn:R05086 OMA LAFKDYG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LAFKDYG PDB 1VB3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1VB3 PDBsum 1VB3 http://www.ebi.ac.uk/pdbsum/1VB3 PROSITE PS00165 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00165 PSORT swissprot:THRC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:THRC_ECOLI PSORT-B swissprot:THRC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:THRC_ECOLI PSORT2 swissprot:THRC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:THRC_ECOLI Pfam PF00291 http://pfam.xfam.org/family/PF00291 Pfam PF14821 http://pfam.xfam.org/family/PF14821 Phobius swissprot:THRC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:THRC_ECOLI PhylomeDB P00934 http://phylomedb.org/?seqid=P00934 ProteinModelPortal P00934 http://www.proteinmodelportal.org/query/uniprot/P00934 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6316258 http://www.ncbi.nlm.nih.gov/pubmed/6316258 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 7907888 http://www.ncbi.nlm.nih.gov/pubmed/7907888 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 RefSeq NP_414545 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414545 RefSeq WP_000781074 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000781074 SMR P00934 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00934 STRING 511145.b0004 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0004&targetmode=cogs STRING COG0498 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0498&targetmode=cogs SUPFAM SSF53686 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53686 SWISS-2DPAGE P00934 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P00934 TIGRFAMs TIGR00260 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00260 UniProtKB THRC_ECOLI http://www.uniprot.org/uniprot/THRC_ECOLI UniProtKB-AC P00934 http://www.uniprot.org/uniprot/P00934 charge swissprot:THRC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:THRC_ECOLI eggNOG COG0498 http://eggnogapi.embl.de/nog_data/html/tree/COG0498 eggNOG ENOG4105D98 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D98 epestfind swissprot:THRC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:THRC_ECOLI garnier swissprot:THRC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:THRC_ECOLI helixturnhelix swissprot:THRC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:THRC_ECOLI hmoment swissprot:THRC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:THRC_ECOLI iep swissprot:THRC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:THRC_ECOLI inforesidue swissprot:THRC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:THRC_ECOLI octanol swissprot:THRC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:THRC_ECOLI pepcoil swissprot:THRC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:THRC_ECOLI pepdigest swissprot:THRC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:THRC_ECOLI pepinfo swissprot:THRC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:THRC_ECOLI pepnet swissprot:THRC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:THRC_ECOLI pepstats swissprot:THRC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:THRC_ECOLI pepwheel swissprot:THRC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:THRC_ECOLI pepwindow swissprot:THRC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:THRC_ECOLI sigcleave swissprot:THRC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:THRC_ECOLI ## Database ID URL or Descriptions # AltName 2-deoxy-D-gluconate 3-dehydrogenase {ECO:0000303|PubMed 23437267} # AltName 2-keto-3-deoxygluconate oxidoreductase {ECO 0000303|Ref.4} # AltName 20-ketosteroid reductase {ECO:0000303|PubMed 24509771} # AltName KDUD_ECOLI 2-keto-3-deoxygluconate 5-dehydrogenase # BIOPHYSICOCHEMICAL PROPERTIES KDUD_ECOLI Kinetic parameters KM=30 mM for 2-keto-3-deoxygluconate {ECO 0000269|Ref.4}; KM=0.230 mM for 11-deoxycorticosterone {ECO 0000269|PubMed 24509771}; KM=0.190 mM for 11-deoxycortisol {ECO 0000269|PubMed 24509771}; KM=544.8 mM for D-gluconate {ECO 0000269|PubMed 24509771}; KM=184.5 mM for 5-keto-D-gluconate {ECO 0000269|PubMed 24509771}; KM=3231 mM for 1,2-propanediol {ECO 0000269|PubMed 24509771}; KM=0.037 mM for NADH {ECO 0000269|PubMed 24509771}; KM=0.285 mM for NAD(+) {ECO 0000269|PubMed 24509771}; Note=kcat is 3.1 min(-1) for 11-DOC reduction. kcat is 16.6 min(-1) for 11-deoxycortisol (RSS) reduction. kcat is 58.3 min(- 1) for D-gluconate oxidation. kcat is 30.7 min(-1) for 5-keto-D- gluconate reduction. kcat is 18.3 min(-1) for 1,2-propanediol oxidation. {ECO 0000269|PubMed 24509771}; pH dependence Optimum pH is 7.0 for the reduction of 11-DOC, and 9.5 for the oxidation of D-gluconate. {ECO 0000269|PubMed 24509771}; Temperature dependence Optimum temperature is 37 degrees Celsius for the reduction of 11-DOC. {ECO 0000269|PubMed 24509771}; # BIOTECHNOLOGY Could be used for the production of valuable bioactive 20-hydroxysteroids; these compounds have potential for pharmaceutical applications as inhibitors of steroid hormone metabolizing enzymes, for the treatment of breast cancer, endometriosis, and prostate diseases in humans. {ECO:0000305|PubMed 24509771}. # BioGrid 4262312 22 # CATALYTIC ACTIVITY 2-dehydro-3-deoxy-D-gluconate + NAD(+) = (4S)- 4,6-dihydroxy-2,5-dioxohexanoate + NADH. {ECO 0000269|Ref.4}. # CATALYTIC ACTIVITY 4-pregnen-20,21-diol-3-one + NAD(+) = 11- deoxycorticosterone + NADH. {ECO:0000269|PubMed 24509771}. # CAUTION Most strains of E.coli do not exhibit 20-ketosteroid reductase activity against steroid substrates such as 11-DOC, despite containing a full-length kduD gene. This activity is observed in the K12 / DH5-alpha strain, whose disruption of the kdgR gene leads to the constitutive expression of KduD in this strain. {ECO:0000305|PubMed 24509771}. # EcoGene EG12361 kduD # FUNCTION KDUD_ECOLI Catalyzes the reversible reduction of 2,5-diketo-3- deoxygluconate (DKII or 4,6-dihydroxy-2,5-dioxohexanoate) into 2- keto-3-deoxygluconate (KDG or 2-dehydro-3-deoxygluconate) with a concomitant oxidation of NADH (Ref.4). To a lesser extent, can also reduce 5-keto-D-gluconate and oxidize D-gluconate and 1,2- propanediol (PubMed 24509771). Together with KduI, seems to play a role in the catabolism of hexuronates under osmotic stress conditions, substituting for the regular hexuronate degrading enzymes UxaABC and UxuAB whose expression is repressed in these conditions (PubMed 23437267). In vitro, also exhibits NADH- dependent 20-ketosteroid reductase activity against eukaryotic steroid hormone 11-deoxycorticosterone (11-DOC), which is converted into the product 4-pregnen-20,21-diol-3-one. In addition to 11-DOC, five other C21 steroid compounds (11-deoxycortisol, cortisol, corticosterone, cortisone, and 21-hydroxypregnenolone) are reduced by KduD, but steroids lacking the hydroxyl group at C21 position, such as pregnenolone, testosterone propionate, cortisone acetate, or progesterone, cannot be used as substrate (PubMed 24509771). {ECO 0000269|PubMed 23437267, ECO 0000269|PubMed 24509771, ECO 0000269|Ref.4}. # GO_function GO:0008678 2-deoxy-D-gluconate 3-dehydrogenase activity; IEA:InterPro. # GO_function GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IDA:EcoCyc. # GO_function GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IDA:EcoCyc. # GO_function GO:0047001 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase activity; IEA:UniProtKB-EC. # GO_function GO:0051287 NAD binding; IEA:InterPro. # GO_process GO:0019698 D-galacturonate catabolic process; IEP:EcoCyc. # GO_process GO:0042840 D-glucuronate catabolic process; IEP:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.720 -; 1. # INDUCTION KDUD_ECOLI Is under the control of KdgR repressor (Probable). Its expression is up-regulated in the presence of galacturonate and glucuronate (PubMed 23437267). Is also up-regulated in intestinal E.coli of mice fed a lactose-rich diet and down-regulated in E.coli of mice on a casein-rich diet (PubMed 22427493). {ECO 0000269|PubMed 22427493, ECO 0000269|PubMed 23437267, ECO 0000305|PubMed 15528647}. # IntAct P37769 2 # InterPro IPR002347 SDR_fam # InterPro IPR011286 2-deoxy-D-gluc_3_DH # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR020904 Sc_DH/Rdtase_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00040 Pentose and glucuronate interconversions # Organism KDUD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR24322 PTHR24322; 2 # PATRIC 32121102 VBIEscCol129921_2940 # PIR C65067 C65067 # PRINTS PR00080 SDRFAMILY # PRINTS PR00081 GDHRDH # PROSITE PS00061 ADH_SHORT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase {ECO:0000303|PubMed 24509771} # RefSeq NP_417319 NC_000913.3 # RefSeq WP_000603502 NZ_LN832404.1 # SIMILARITY Belongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO 0000305}. # SUBUNIT Homotetramer. {ECO:0000305|PubMed 24509771}. # SUPFAM SSF51735 SSF51735 # TIGRFAMs TIGR01832 kduD # eggNOG ENOG4105CHR Bacteria # eggNOG ENOG410XNW1 LUCA BLAST swissprot:KDUD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:KDUD_ECOLI BioCyc ECOL316407:JW2810-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2810-MONOMER BioCyc EcoCyc:KDUD-MONOMER http://biocyc.org/getid?id=EcoCyc:KDUD-MONOMER BioCyc MetaCyc:KDUD-MONOMER http://biocyc.org/getid?id=MetaCyc:KDUD-MONOMER COG COG1028 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1028 DOI 10.1007/s00253-014-5551-8 http://dx.doi.org/10.1007/s00253-014-5551-8 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1099/mic.0.27041-0 http://dx.doi.org/10.1099/mic.0.27041-0 DOI 10.1111/j.1365-2958.1991.tb02149.x http://dx.doi.org/10.1111/j.1365-2958.1991.tb02149.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AEM.00244-12 http://dx.doi.org/10.1128/AEM.00244-12 DOI 10.1371/journal.pone.0056906 http://dx.doi.org/10.1371/journal.pone.0056906 EC_number EC:1.1.1.- {ECO:0000269|PubMed:24509771} http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.- {ECO:0000269|PubMed:24509771} EC_number EC:1.1.1.127 {ECO:0000269|Ref.4} http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.127 {ECO:0000269|Ref.4} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J03732 http://www.ebi.ac.uk/ena/data/view/J03732 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 ENZYME 1.1.1.- {ECO:0000269|PubMed:24509771} http://enzyme.expasy.org/EC/1.1.1.- {ECO:0000269|PubMed:24509771} ENZYME 1.1.1.127 {ECO:0000269|Ref.4} http://enzyme.expasy.org/EC/1.1.1.127 {ECO:0000269|Ref.4} EchoBASE EB2264 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2264 EcoGene EG12361 http://www.ecogene.org/geneInfo.php?eg_id=EG12361 EnsemblBacteria AAC75881 http://www.ensemblgenomes.org/id/AAC75881 EnsemblBacteria AAC75881 http://www.ensemblgenomes.org/id/AAC75881 EnsemblBacteria BAE76911 http://www.ensemblgenomes.org/id/BAE76911 EnsemblBacteria BAE76911 http://www.ensemblgenomes.org/id/BAE76911 EnsemblBacteria BAE76911 http://www.ensemblgenomes.org/id/BAE76911 EnsemblBacteria b2842 http://www.ensemblgenomes.org/id/b2842 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008678 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008678 GO_function GO:0016616 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016616 GO_function GO:0033764 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033764 GO_function GO:0047001 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047001 GO_function GO:0051287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051287 GO_process GO:0019698 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019698 GO_process GO:0042840 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042840 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 947323 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947323 InParanoid P37769 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37769 IntAct P37769 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37769* IntEnz 1.1.1.- {ECO:0000269|PubMed:24509771} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.- {ECO:0000269|PubMed:24509771} IntEnz 1.1.1.127 {ECO:0000269|Ref.4} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.127 {ECO:0000269|Ref.4} InterPro IPR002347 http://www.ebi.ac.uk/interpro/entry/IPR002347 InterPro IPR011286 http://www.ebi.ac.uk/interpro/entry/IPR011286 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR020904 http://www.ebi.ac.uk/interpro/entry/IPR020904 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2810 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2810 KEGG_Gene eco:b2842 http://www.genome.jp/dbget-bin/www_bget?eco:b2842 KEGG_Orthology KO:K00065 http://www.genome.jp/dbget-bin/www_bget?KO:K00065 KEGG_Pathway ko00040 http://www.genome.jp/kegg-bin/show_pathway?ko00040 KEGG_Reaction rn:R01542 http://www.genome.jp/dbget-bin/www_bget?rn:R01542 OMA DASAYIH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DASAYIH PANTHER PTHR24322 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24322 PRINTS PR00080 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00080 PRINTS PR00081 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00081 PROSITE PS00061 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00061 PSORT swissprot:KDUD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:KDUD_ECOLI PSORT-B swissprot:KDUD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:KDUD_ECOLI PSORT2 swissprot:KDUD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:KDUD_ECOLI Phobius swissprot:KDUD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:KDUD_ECOLI PhylomeDB P37769 http://phylomedb.org/?seqid=P37769 ProteinModelPortal P37769 http://www.proteinmodelportal.org/query/uniprot/P37769 PubMed 15528647 http://www.ncbi.nlm.nih.gov/pubmed/15528647 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1766386 http://www.ncbi.nlm.nih.gov/pubmed/1766386 PubMed 22427493 http://www.ncbi.nlm.nih.gov/pubmed/22427493 PubMed 23437267 http://www.ncbi.nlm.nih.gov/pubmed/23437267 PubMed 24509771 http://www.ncbi.nlm.nih.gov/pubmed/24509771 PubMed 2836407 http://www.ncbi.nlm.nih.gov/pubmed/2836407 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417319 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417319 RefSeq WP_000603502 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000603502 SMR P37769 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37769 STRING 511145.b2842 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2842&targetmode=cogs STRING COG1028 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1028&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 TIGRFAMs TIGR01832 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01832 UniProtKB KDUD_ECOLI http://www.uniprot.org/uniprot/KDUD_ECOLI UniProtKB-AC P37769 http://www.uniprot.org/uniprot/P37769 charge swissprot:KDUD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:KDUD_ECOLI eggNOG ENOG4105CHR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CHR eggNOG ENOG410XNW1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNW1 epestfind swissprot:KDUD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:KDUD_ECOLI garnier swissprot:KDUD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:KDUD_ECOLI helixturnhelix swissprot:KDUD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:KDUD_ECOLI hmoment swissprot:KDUD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:KDUD_ECOLI iep swissprot:KDUD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:KDUD_ECOLI inforesidue swissprot:KDUD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:KDUD_ECOLI octanol swissprot:KDUD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:KDUD_ECOLI pepcoil swissprot:KDUD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:KDUD_ECOLI pepdigest swissprot:KDUD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:KDUD_ECOLI pepinfo swissprot:KDUD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:KDUD_ECOLI pepnet swissprot:KDUD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:KDUD_ECOLI pepstats swissprot:KDUD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:KDUD_ECOLI pepwheel swissprot:KDUD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:KDUD_ECOLI pepwindow swissprot:KDUD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:KDUD_ECOLI sigcleave swissprot:KDUD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:KDUD_ECOLI ## Database ID URL or Descriptions # BioGrid 4262805 5 # EcoGene EG13587 yahC # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR009476 DUF1097 # Organism YAHC_ECOLI Escherichia coli (strain K12) # PATRIC 32115763 VBIEscCol129921_0324 # PIR E64758 E64758 # Pfam PF06496 DUF1097 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAHC_ECOLI Uncharacterized protein YahC # RefSeq NP_414851 NC_000913.3 # RefSeq WP_001013892 NZ_LN832404.1 # SIMILARITY To E.coli YcdZ. {ECO 0000305}. # SUBCELLULAR LOCATION YAHC_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # eggNOG ENOG4105SZ2 Bacteria # eggNOG ENOG41120CM LUCA BLAST swissprot:YAHC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAHC_ECOLI BioCyc ECOL316407:JW0309-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0309-MONOMER BioCyc EcoCyc:G6182-MONOMER http://biocyc.org/getid?id=EcoCyc:G6182-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB3357 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3357 EcoGene EG13587 http://www.ecogene.org/geneInfo.php?eg_id=EG13587 EnsemblBacteria AAC73420 http://www.ensemblgenomes.org/id/AAC73420 EnsemblBacteria AAC73420 http://www.ensemblgenomes.org/id/AAC73420 EnsemblBacteria BAE76100 http://www.ensemblgenomes.org/id/BAE76100 EnsemblBacteria BAE76100 http://www.ensemblgenomes.org/id/BAE76100 EnsemblBacteria BAE76100 http://www.ensemblgenomes.org/id/BAE76100 EnsemblBacteria b0317 http://www.ensemblgenomes.org/id/b0317 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 947337 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947337 HOGENOM HOG000284435 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000284435&db=HOGENOM6 InterPro IPR009476 http://www.ebi.ac.uk/interpro/entry/IPR009476 KEGG_Gene ecj:JW0309 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0309 KEGG_Gene eco:b0317 http://www.genome.jp/dbget-bin/www_bget?eco:b0317 OMA WVAVIAW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WVAVIAW PSORT swissprot:YAHC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAHC_ECOLI PSORT-B swissprot:YAHC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAHC_ECOLI PSORT2 swissprot:YAHC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAHC_ECOLI Pfam PF06496 http://pfam.xfam.org/family/PF06496 Phobius swissprot:YAHC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAHC_ECOLI ProteinModelPortal P77219 http://www.proteinmodelportal.org/query/uniprot/P77219 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414851 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414851 RefSeq WP_001013892 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001013892 STRING 511145.b0317 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0317&targetmode=cogs UniProtKB YAHC_ECOLI http://www.uniprot.org/uniprot/YAHC_ECOLI UniProtKB-AC P77219 http://www.uniprot.org/uniprot/P77219 charge swissprot:YAHC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAHC_ECOLI eggNOG ENOG4105SZ2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105SZ2 eggNOG ENOG41120CM http://eggnogapi.embl.de/nog_data/html/tree/ENOG41120CM epestfind swissprot:YAHC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAHC_ECOLI garnier swissprot:YAHC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAHC_ECOLI helixturnhelix swissprot:YAHC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAHC_ECOLI hmoment swissprot:YAHC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAHC_ECOLI iep swissprot:YAHC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAHC_ECOLI inforesidue swissprot:YAHC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAHC_ECOLI octanol swissprot:YAHC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAHC_ECOLI pepcoil swissprot:YAHC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAHC_ECOLI pepdigest swissprot:YAHC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAHC_ECOLI pepinfo swissprot:YAHC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAHC_ECOLI pepnet swissprot:YAHC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAHC_ECOLI pepstats swissprot:YAHC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAHC_ECOLI pepwheel swissprot:YAHC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAHC_ECOLI pepwindow swissprot:YAHC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAHC_ECOLI sigcleave swissprot:YAHC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAHC_ECOLI ## Database ID URL or Descriptions # BioGrid 4261019 11 # CDD cd06848 GCS_H # COFACTOR Name=(R)-lipoate; Xref=ChEBI:CHEBI 83088; Note=Binds 1 lipoyl cofactor covalently.; # EcoGene EG10371 gcvH # FUNCTION GCSH_ECOLI The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005960 glycine cleavage complex; IEA:InterPro. # GO_function GO:0031405 lipoic acid binding; ISS:EcoliWiki. # GO_process GO:0019464 glycine decarboxylation via glycine cleavage system; ISS:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0008289 lipid binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # HAMAP MF_00272 GcvH # IntAct P0A6T9 2 # InterPro IPR000089 Biotin_lipoyl # InterPro IPR002930 GCV_H # InterPro IPR003016 2-oxoA_DH_lipoyl-BS # InterPro IPR011053 Single_hybrid_motif # InterPro IPR017453 GCV_H_sub # InterPro IPR033753 GCV_H/Fam206 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Pathway ko00630 Glyoxylate and dicarboxylate metabolism # Organism GCSH_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11715 PTHR11715 # PATRIC 32121222 VBIEscCol129921_2999 # PDB 3A7A X-ray; 3.10 A; B/D=2-129 # PDB 3A7L X-ray; 1.30 A; A=2-129 # PDB 3A8I X-ray; 1.99 A; E/F=1-129 # PDB 3A8J X-ray; 1.98 A; E/F=1-129 # PDB 3A8K X-ray; 1.95 A; E/F=1-129 # PDB 3AB9 X-ray; 1.65 A; A=1-129 # PIR A56623 A56623 # PROSITE PS00189 LIPOYL # PROSITE PS50968 BIOTINYL_LIPOYL # Pfam PF01597 GCV_H # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Glycine cleavage system H protein {ECO:0000255|HAMAP-Rule MF_00272} # RefSeq NP_417380 NC_000913.3 # RefSeq WP_001295377 NZ_LN832404.1 # SIMILARITY Belongs to the GcvH family. {ECO:0000255|HAMAP- Rule MF_00272}. # SIMILARITY Contains 1 lipoyl-binding domain. {ECO:0000255|HAMAP- Rule MF_00272}. # SUBUNIT The glycine cleavage system is composed of four proteins P, T, L and H. # SUPFAM SSF51230 SSF51230 # TIGRFAMs TIGR00527 gcvH # eggNOG COG0509 LUCA BLAST swissprot:GCSH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GCSH_ECOLI BioCyc ECOL316407:JW2872-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2872-MONOMER BioCyc EcoCyc:GCVH-MONOMER http://biocyc.org/getid?id=EcoCyc:GCVH-MONOMER BioCyc MetaCyc:GCVH-MONOMER http://biocyc.org/getid?id=MetaCyc:GCVH-MONOMER COG COG0509 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0509 DOI 10.1016/0378-1119(94)90349-2 http://dx.doi.org/10.1016/0378-1119(94)90349-2 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1432-1033.1993.tb18172.x http://dx.doi.org/10.1111/j.1432-1033.1993.tb18172.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.3109/10425179109008434 http://dx.doi.org/10.3109/10425179109008434 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L20872 http://www.ebi.ac.uk/ena/data/view/L20872 EMBL M57690 http://www.ebi.ac.uk/ena/data/view/M57690 EMBL M97263 http://www.ebi.ac.uk/ena/data/view/M97263 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EMBL X73958 http://www.ebi.ac.uk/ena/data/view/X73958 EchoBASE EB0366 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0366 EcoGene EG10371 http://www.ecogene.org/geneInfo.php?eg_id=EG10371 EnsemblBacteria AAC75942 http://www.ensemblgenomes.org/id/AAC75942 EnsemblBacteria AAC75942 http://www.ensemblgenomes.org/id/AAC75942 EnsemblBacteria BAE76969 http://www.ensemblgenomes.org/id/BAE76969 EnsemblBacteria BAE76969 http://www.ensemblgenomes.org/id/BAE76969 EnsemblBacteria BAE76969 http://www.ensemblgenomes.org/id/BAE76969 EnsemblBacteria b2904 http://www.ensemblgenomes.org/id/b2904 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005960 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005960 GO_function GO:0031405 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031405 GO_process GO:0019464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019464 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0008289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GeneID 947393 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947393 HAMAP MF_00272 http://hamap.expasy.org/unirule/MF_00272 HOGENOM HOG000239392 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000239392&db=HOGENOM6 InParanoid P0A6T9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6T9 IntAct P0A6T9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6T9* InterPro IPR000089 http://www.ebi.ac.uk/interpro/entry/IPR000089 InterPro IPR002930 http://www.ebi.ac.uk/interpro/entry/IPR002930 InterPro IPR003016 http://www.ebi.ac.uk/interpro/entry/IPR003016 InterPro IPR011053 http://www.ebi.ac.uk/interpro/entry/IPR011053 InterPro IPR017453 http://www.ebi.ac.uk/interpro/entry/IPR017453 InterPro IPR033753 http://www.ebi.ac.uk/interpro/entry/IPR033753 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Gene ecj:JW2872 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2872 KEGG_Gene eco:b2904 http://www.genome.jp/dbget-bin/www_bget?eco:b2904 KEGG_Orthology KO:K02437 http://www.genome.jp/dbget-bin/www_bget?KO:K02437 KEGG_Pathway ko00630 http://www.genome.jp/kegg-bin/show_pathway?ko00630 KEGG_Reaction rn:R01221 http://www.genome.jp/dbget-bin/www_bget?rn:R01221 OMA NTDPYGE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NTDPYGE PANTHER PTHR11715 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11715 PDB 3A7A http://www.ebi.ac.uk/pdbe-srv/view/entry/3A7A PDB 3A7L http://www.ebi.ac.uk/pdbe-srv/view/entry/3A7L PDB 3A8I http://www.ebi.ac.uk/pdbe-srv/view/entry/3A8I PDB 3A8J http://www.ebi.ac.uk/pdbe-srv/view/entry/3A8J PDB 3A8K http://www.ebi.ac.uk/pdbe-srv/view/entry/3A8K PDB 3AB9 http://www.ebi.ac.uk/pdbe-srv/view/entry/3AB9 PDBsum 3A7A http://www.ebi.ac.uk/pdbsum/3A7A PDBsum 3A7L http://www.ebi.ac.uk/pdbsum/3A7L PDBsum 3A8I http://www.ebi.ac.uk/pdbsum/3A8I PDBsum 3A8J http://www.ebi.ac.uk/pdbsum/3A8J PDBsum 3A8K http://www.ebi.ac.uk/pdbsum/3A8K PDBsum 3AB9 http://www.ebi.ac.uk/pdbsum/3AB9 PROSITE PS00189 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00189 PROSITE PS50968 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50968 PSORT swissprot:GCSH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GCSH_ECOLI PSORT-B swissprot:GCSH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GCSH_ECOLI PSORT2 swissprot:GCSH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GCSH_ECOLI Pfam PF01597 http://pfam.xfam.org/family/PF01597 Phobius swissprot:GCSH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GCSH_ECOLI PhylomeDB P0A6T9 http://phylomedb.org/?seqid=P0A6T9 ProteinModelPortal P0A6T9 http://www.proteinmodelportal.org/query/uniprot/P0A6T9 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1802033 http://www.ncbi.nlm.nih.gov/pubmed/1802033 PubMed 8181752 http://www.ncbi.nlm.nih.gov/pubmed/8181752 PubMed 8219277 http://www.ncbi.nlm.nih.gov/pubmed/8219277 PubMed 8375392 http://www.ncbi.nlm.nih.gov/pubmed/8375392 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417380 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417380 RefSeq WP_001295377 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295377 SMR P0A6T9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6T9 STRING 511145.b2904 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2904&targetmode=cogs STRING COG0509 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0509&targetmode=cogs SUPFAM SSF51230 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51230 TIGRFAMs TIGR00527 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00527 UniProtKB GCSH_ECOLI http://www.uniprot.org/uniprot/GCSH_ECOLI UniProtKB-AC P0A6T9 http://www.uniprot.org/uniprot/P0A6T9 charge swissprot:GCSH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GCSH_ECOLI eggNOG COG0509 http://eggnogapi.embl.de/nog_data/html/tree/COG0509 epestfind swissprot:GCSH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GCSH_ECOLI garnier swissprot:GCSH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GCSH_ECOLI helixturnhelix swissprot:GCSH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GCSH_ECOLI hmoment swissprot:GCSH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GCSH_ECOLI iep swissprot:GCSH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GCSH_ECOLI inforesidue swissprot:GCSH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GCSH_ECOLI octanol swissprot:GCSH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GCSH_ECOLI pepcoil swissprot:GCSH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GCSH_ECOLI pepdigest swissprot:GCSH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GCSH_ECOLI pepinfo swissprot:GCSH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GCSH_ECOLI pepnet swissprot:GCSH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GCSH_ECOLI pepstats swissprot:GCSH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GCSH_ECOLI pepwheel swissprot:GCSH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GCSH_ECOLI pepwindow swissprot:GCSH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GCSH_ECOLI sigcleave swissprot:GCSH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GCSH_ECOLI ## Database ID URL or Descriptions # AltName FLGC_ECOLI Putative proximal rod protein # BioGrid 4261762 9 # EcoGene EG14267 flgC # GO_component GO:0009424 bacterial-type flagellum hook; IBA:GO_Central. # GO_component GO:0030694 bacterial-type flagellum basal body, rod; IEA:InterPro. # GO_process GO:0071978 bacterial-type flagellum-dependent swarming motility; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0048870 cell motility # IntAct P0ABX2 7 # InterPro IPR001444 Flag_bb_rod_N # InterPro IPR006299 FlgC # InterPro IPR010930 Flg_bb/hook_C_dom # InterPro IPR019776 Flagellar_basal_body_rod_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Pathway ko02040 Flagellar assembly # Organism FLGC_ECOLI Escherichia coli (strain K12) # PATRIC 32117389 VBIEscCol129921_1117 # PIR G64850 G64850 # PROSITE PS00588 FLAGELLA_BB_ROD # Pfam PF00460 Flg_bb_rod # Pfam PF06429 Flg_bbr_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FLGC_ECOLI Flagellar basal-body rod protein FlgC # RefSeq NP_415592 NC_000913.3 # RefSeq WP_001196460 NZ_LN832404.1 # SIMILARITY Belongs to the flagella basal body rod proteins family. {ECO 0000305}. # SUBCELLULAR LOCATION FLGC_ECOLI Bacterial flagellum basal body. # SUBUNIT FLGC_ECOLI The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each. # TIGRFAMs TIGR01395 FlgC # eggNOG COG1558 LUCA # eggNOG ENOG4108ZC9 Bacteria BLAST swissprot:FLGC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLGC_ECOLI BioCyc ECOL316407:JW1061-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1061-MONOMER BioCyc EcoCyc:FLGC-FLAGELLAR-MOTOR-ROD-PROTEIN http://biocyc.org/getid?id=EcoCyc:FLGC-FLAGELLAR-MOTOR-ROD-PROTEIN COG COG1558 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1558 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4015 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4015 EcoGene EG14267 http://www.ecogene.org/geneInfo.php?eg_id=EG14267 EnsemblBacteria AAC74158 http://www.ensemblgenomes.org/id/AAC74158 EnsemblBacteria AAC74158 http://www.ensemblgenomes.org/id/AAC74158 EnsemblBacteria BAA35882 http://www.ensemblgenomes.org/id/BAA35882 EnsemblBacteria BAA35882 http://www.ensemblgenomes.org/id/BAA35882 EnsemblBacteria BAA35882 http://www.ensemblgenomes.org/id/BAA35882 EnsemblBacteria b1074 http://www.ensemblgenomes.org/id/b1074 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009424 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009424 GO_component GO:0030694 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030694 GO_process GO:0071978 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071978 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 GeneID 946687 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946687 HOGENOM HOG000257304 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000257304&db=HOGENOM6 InParanoid P0ABX2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABX2 IntAct P0ABX2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABX2* InterPro IPR001444 http://www.ebi.ac.uk/interpro/entry/IPR001444 InterPro IPR006299 http://www.ebi.ac.uk/interpro/entry/IPR006299 InterPro IPR010930 http://www.ebi.ac.uk/interpro/entry/IPR010930 InterPro IPR019776 http://www.ebi.ac.uk/interpro/entry/IPR019776 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW1061 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1061 KEGG_Gene eco:b1074 http://www.genome.jp/dbget-bin/www_bget?eco:b1074 KEGG_Orthology KO:K02388 http://www.genome.jp/dbget-bin/www_bget?KO:K02388 KEGG_Pathway ko02040 http://www.genome.jp/kegg-bin/show_pathway?ko02040 OMA YVNYPNV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YVNYPNV PROSITE PS00588 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00588 PSORT swissprot:FLGC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLGC_ECOLI PSORT-B swissprot:FLGC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLGC_ECOLI PSORT2 swissprot:FLGC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLGC_ECOLI Pfam PF00460 http://pfam.xfam.org/family/PF00460 Pfam PF06429 http://pfam.xfam.org/family/PF06429 Phobius swissprot:FLGC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLGC_ECOLI PhylomeDB P0ABX2 http://phylomedb.org/?seqid=P0ABX2 ProteinModelPortal P0ABX2 http://www.proteinmodelportal.org/query/uniprot/P0ABX2 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415592 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415592 RefSeq WP_001196460 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001196460 SMR P0ABX2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABX2 STRING 511145.b1074 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1074&targetmode=cogs STRING COG1558 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1558&targetmode=cogs TIGRFAMs TIGR01395 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01395 UniProtKB FLGC_ECOLI http://www.uniprot.org/uniprot/FLGC_ECOLI UniProtKB-AC P0ABX2 http://www.uniprot.org/uniprot/P0ABX2 charge swissprot:FLGC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLGC_ECOLI eggNOG COG1558 http://eggnogapi.embl.de/nog_data/html/tree/COG1558 eggNOG ENOG4108ZC9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZC9 epestfind swissprot:FLGC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLGC_ECOLI garnier swissprot:FLGC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLGC_ECOLI helixturnhelix swissprot:FLGC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLGC_ECOLI hmoment swissprot:FLGC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLGC_ECOLI iep swissprot:FLGC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLGC_ECOLI inforesidue swissprot:FLGC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLGC_ECOLI octanol swissprot:FLGC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLGC_ECOLI pepcoil swissprot:FLGC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLGC_ECOLI pepdigest swissprot:FLGC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLGC_ECOLI pepinfo swissprot:FLGC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLGC_ECOLI pepnet swissprot:FLGC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLGC_ECOLI pepstats swissprot:FLGC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLGC_ECOLI pepwheel swissprot:FLGC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLGC_ECOLI pepwindow swissprot:FLGC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLGC_ECOLI sigcleave swissprot:FLGC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLGC_ECOLI ## Database ID URL or Descriptions # BioGrid 4260097 13 # EcoGene EG14415 ymgG # HAMAP MF_01455 UPF0757 # InterPro IPR022833 UPF0757_YmgG # InterPro IPR025693 Gly-zipper_OmpA-like_dom # Organism YMGG_ECOLI Escherichia coli (strain K12) # PATRIC 32117584 VBIEscCol129921_1214 # Pfam PF13436 Gly-zipper_OmpA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UPF0757 protein YmgG {ECO:0000255|HAMAP-Rule MF_01455} # RefSeq NP_415690 NC_000913.3 # RefSeq WP_000726974 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA36006.2; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the UPF0757 family. {ECO:0000255|HAMAP- Rule MF_01455}. BLAST swissprot:YMGG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YMGG_ECOLI BioCyc ECOL316407:JW5178-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5178-MONOMER BioCyc EcoCyc:G6612-MONOMER http://biocyc.org/getid?id=EcoCyc:G6612-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14415 http://www.ecogene.org/geneInfo.php?eg_id=EG14415 EnsemblBacteria AAC74256 http://www.ensemblgenomes.org/id/AAC74256 EnsemblBacteria AAC74256 http://www.ensemblgenomes.org/id/AAC74256 EnsemblBacteria BAA36006 http://www.ensemblgenomes.org/id/BAA36006 EnsemblBacteria BAA36006 http://www.ensemblgenomes.org/id/BAA36006 EnsemblBacteria BAA36006 http://www.ensemblgenomes.org/id/BAA36006 EnsemblBacteria b1172 http://www.ensemblgenomes.org/id/b1172 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945728 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945728 HAMAP MF_01455 http://hamap.expasy.org/unirule/MF_01455 HOGENOM HOG000119713 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000119713&db=HOGENOM6 InterPro IPR022833 http://www.ebi.ac.uk/interpro/entry/IPR022833 InterPro IPR025693 http://www.ebi.ac.uk/interpro/entry/IPR025693 KEGG_Gene ecj:JW5178 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5178 KEGG_Gene eco:b1172 http://www.genome.jp/dbget-bin/www_bget?eco:b1172 PSORT swissprot:YMGG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YMGG_ECOLI PSORT-B swissprot:YMGG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YMGG_ECOLI PSORT2 swissprot:YMGG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YMGG_ECOLI Pfam PF13436 http://pfam.xfam.org/family/PF13436 Phobius swissprot:YMGG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YMGG_ECOLI PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415690 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415690 RefSeq WP_000726974 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000726974 STRING 511145.b1172 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1172&targetmode=cogs UniProtKB YMGG_ECOLI http://www.uniprot.org/uniprot/YMGG_ECOLI UniProtKB-AC Q7DFV3 http://www.uniprot.org/uniprot/Q7DFV3 charge swissprot:YMGG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YMGG_ECOLI epestfind swissprot:YMGG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YMGG_ECOLI garnier swissprot:YMGG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YMGG_ECOLI helixturnhelix swissprot:YMGG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YMGG_ECOLI hmoment swissprot:YMGG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YMGG_ECOLI iep swissprot:YMGG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YMGG_ECOLI inforesidue swissprot:YMGG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YMGG_ECOLI octanol swissprot:YMGG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YMGG_ECOLI pepcoil swissprot:YMGG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YMGG_ECOLI pepdigest swissprot:YMGG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YMGG_ECOLI pepinfo swissprot:YMGG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YMGG_ECOLI pepnet swissprot:YMGG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YMGG_ECOLI pepstats swissprot:YMGG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YMGG_ECOLI pepwheel swissprot:YMGG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YMGG_ECOLI pepwindow swissprot:YMGG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YMGG_ECOLI sigcleave swissprot:YMGG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YMGG_ECOLI ## Database ID URL or Descriptions # AltName LCFA_ECOLI Long-chain acyl-CoA synthetase # BIOPHYSICOCHEMICAL PROPERTIES pH dependence: Optimum pH is 7.5 - 7.8. {ECO 0000269|PubMed:15213221}; # BioGrid 4259150 211 # CATALYTIC ACTIVITY ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA. {ECO:0000269|PubMed 15213221}. # EcoGene EG11530 fadD # FUNCTION LCFA_ECOLI Catalyzes the esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. Activity is the highest with fatty acid substrates of > 10 carbon atoms (PubMed 15213221). {ECO 0000269|PubMed 15213221}. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; TAS:EcoCyc. # GO_component GO:0009898 cytoplasmic side of plasma membrane; TAS:EcoCyc. # GO_function GO:0004467 long-chain fatty acid-CoA ligase activity; IDA:EcoCyc. # GO_function GO:0005504 fatty acid binding; IMP:EcoliWiki. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0070538 oleic acid binding; IMP:EcoliWiki. # GO_function GO:0102391 decanoate--CoA ligase activity; IEA:UniProtKB-EC. # GO_process GO:0006629 lipid metabolic process; IMP:EcoliWiki. # GO_process GO:0006631 fatty acid metabolic process; IMP:EcoliWiki. # GO_process GO:0006635 fatty acid beta-oxidation; IDA:EcoCyc. # GO_process GO:0006637 acyl-CoA metabolic process; IDA:EcoCyc. # GO_process GO:0008654 phospholipid biosynthetic process; IMP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0008289 lipid binding # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # INDUCTION Well expressed during log and stationary phase aerobic growth but only poorly expressed during anaerobic growth (at protein level); aerobic expression is suppressed by glucose or C8 fatty acids (PubMed:15213221). {ECO 0000269|PubMed:15213221}. # IntAct P69451 6 # InterPro IPR000873 AMP-dep_Synth/Lig # InterPro IPR020845 AMP-binding_CS # InterPro IPR025110 AMP-bd_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01004 Lipid biosynthesis proteins # KEGG_Pathway ko00071 Fatty acid metabolism # KEGG_Pathway ko03320 PPAR signaling pathway # KEGG_Pathway ko04146 Peroxisome # KEGG_Pathway ko04920 Adipocytokine signaling pathway # Organism LCFA_ECOLI Escherichia coli (strain K12) # PATRIC 32118927 VBIEscCol129921_1881 # PIR E64941 S41589 # PROSITE PS00455 AMP_BINDING # PTM LCFA_ECOLI Post-translationally cleaved by OmpT (PubMed 15213221). {ECO 0000269|PubMed 15213221}. # Pfam PF00501 AMP-binding # Pfam PF13193 AMP-binding_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LCFA_ECOLI Long-chain-fatty-acid--CoA ligase # RefSeq NP_416319 NC_000913.3 # SIMILARITY Belongs to the ATP-dependent AMP-binding enzyme family. {ECO 0000305}. # SUBCELLULAR LOCATION LCFA_ECOLI Membrane {ECO 0000250}; Peripheral membrane protein {ECO 0000250}. Note=Partially membrane-associated. {ECO 0000250}. # SUBUNIT Homodimer. {ECO 0000305}. # TCDB 4.C.1.1 the proposed fatty acid transporter (fat) family # eggNOG COG0318 LUCA # eggNOG ENOG4105CEY Bacteria BLAST swissprot:LCFA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LCFA_ECOLI BioCyc ECOL316407:JW1794-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1794-MONOMER BioCyc EcoCyc:ACYLCOASYN-MONOMER http://biocyc.org/getid?id=EcoCyc:ACYLCOASYN-MONOMER BioCyc MetaCyc:ACYLCOASYN-MONOMER http://biocyc.org/getid?id=MetaCyc:ACYLCOASYN-MONOMER COG COG0318 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0318 COG COG1022 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1022 DOI 10.1007/BF00280412 http://dx.doi.org/10.1007/BF00280412 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M107022200 http://dx.doi.org/10.1074/jbc.M107022200 DOI 10.1074/jbc.M405233200 http://dx.doi.org/10.1074/jbc.M405233200 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.2.1.3 {ECO:0000269|PubMed:15213221} http://www.genome.jp/dbget-bin/www_bget?EC:6.2.1.3 {ECO:0000269|PubMed:15213221} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L02649 http://www.ebi.ac.uk/ena/data/view/L02649 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X70994 http://www.ebi.ac.uk/ena/data/view/X70994 ENZYME 6.2.1.3 {ECO:0000269|PubMed:15213221} http://enzyme.expasy.org/EC/6.2.1.3 {ECO:0000269|PubMed:15213221} EchoBASE EB1492 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1492 EcoGene EG11530 http://www.ecogene.org/geneInfo.php?eg_id=EG11530 EnsemblBacteria AAC74875 http://www.ensemblgenomes.org/id/AAC74875 EnsemblBacteria AAC74875 http://www.ensemblgenomes.org/id/AAC74875 EnsemblBacteria BAA15609 http://www.ensemblgenomes.org/id/BAA15609 EnsemblBacteria BAA15609 http://www.ensemblgenomes.org/id/BAA15609 EnsemblBacteria BAA15609 http://www.ensemblgenomes.org/id/BAA15609 EnsemblBacteria b1805 http://www.ensemblgenomes.org/id/b1805 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0009898 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009898 GO_function GO:0004467 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004467 GO_function GO:0005504 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005504 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0070538 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070538 GO_function GO:0102391 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0102391 GO_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GO_process GO:0006631 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006631 GO_process GO:0006635 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006635 GO_process GO:0006637 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006637 GO_process GO:0008654 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008654 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0008289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GeneID 946327 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946327 HOGENOM HOG000229983 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000229983&db=HOGENOM6 InParanoid P69451 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P69451 IntAct P69451 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69451* IntEnz 6.2.1.3 {ECO:0000269|PubMed:15213221} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.2.1.3 {ECO:0000269|PubMed:15213221} InterPro IPR000873 http://www.ebi.ac.uk/interpro/entry/IPR000873 InterPro IPR020845 http://www.ebi.ac.uk/interpro/entry/IPR020845 InterPro IPR025110 http://www.ebi.ac.uk/interpro/entry/IPR025110 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01004 http://www.genome.jp/dbget-bin/www_bget?ko01004 KEGG_Gene ecj:JW1794 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1794 KEGG_Gene eco:b1805 http://www.genome.jp/dbget-bin/www_bget?eco:b1805 KEGG_Orthology KO:K01897 http://www.genome.jp/dbget-bin/www_bget?KO:K01897 KEGG_Pathway ko00071 http://www.genome.jp/kegg-bin/show_pathway?ko00071 KEGG_Pathway ko03320 http://www.genome.jp/kegg-bin/show_pathway?ko03320 KEGG_Pathway ko04146 http://www.genome.jp/kegg-bin/show_pathway?ko04146 KEGG_Pathway ko04920 http://www.genome.jp/kegg-bin/show_pathway?ko04920 KEGG_Reaction rn:R01280 http://www.genome.jp/dbget-bin/www_bget?rn:R01280 OMA ITFSDFH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ITFSDFH PROSITE PS00455 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00455 PSORT swissprot:LCFA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LCFA_ECOLI PSORT-B swissprot:LCFA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LCFA_ECOLI PSORT2 swissprot:LCFA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LCFA_ECOLI Pfam PF00501 http://pfam.xfam.org/family/PF00501 Pfam PF13193 http://pfam.xfam.org/family/PF13193 Phobius swissprot:LCFA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LCFA_ECOLI PhylomeDB P69451 http://phylomedb.org/?seqid=P69451 ProteinModelPortal P69451 http://www.proteinmodelportal.org/query/uniprot/P69451 PubMed 12034706 http://www.ncbi.nlm.nih.gov/pubmed/12034706 PubMed 1460045 http://www.ncbi.nlm.nih.gov/pubmed/1460045 PubMed 15213221 http://www.ncbi.nlm.nih.gov/pubmed/15213221 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8107670 http://www.ncbi.nlm.nih.gov/pubmed/8107670 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416319 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416319 SMR P69451 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69451 STRING 511145.b1805 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1805&targetmode=cogs STRING COG0318 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0318&targetmode=cogs STRING COG1022 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1022&targetmode=cogs TCDB 4.C.1.1 http://www.tcdb.org/search/result.php?tc=4.C.1.1 UniProtKB LCFA_ECOLI http://www.uniprot.org/uniprot/LCFA_ECOLI UniProtKB-AC P69451 http://www.uniprot.org/uniprot/P69451 charge swissprot:LCFA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LCFA_ECOLI eggNOG COG0318 http://eggnogapi.embl.de/nog_data/html/tree/COG0318 eggNOG ENOG4105CEY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CEY epestfind swissprot:LCFA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LCFA_ECOLI garnier swissprot:LCFA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LCFA_ECOLI helixturnhelix swissprot:LCFA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LCFA_ECOLI hmoment swissprot:LCFA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LCFA_ECOLI iep swissprot:LCFA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LCFA_ECOLI inforesidue swissprot:LCFA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LCFA_ECOLI octanol swissprot:LCFA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LCFA_ECOLI pepcoil swissprot:LCFA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LCFA_ECOLI pepdigest swissprot:LCFA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LCFA_ECOLI pepinfo swissprot:LCFA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LCFA_ECOLI pepnet swissprot:LCFA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LCFA_ECOLI pepstats swissprot:LCFA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LCFA_ECOLI pepwheel swissprot:LCFA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LCFA_ECOLI pepwindow swissprot:LCFA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LCFA_ECOLI sigcleave swissprot:LCFA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LCFA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259219 104 # EcoGene EG14313 yqaE # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR000612 PMP3 # Organism YQAE_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21659 PTHR21659 # PATRIC 32120722 VBIEscCol129921_2758 # PIR C65046 C65046 # PROSITE PS01309 UPF0057 # Pfam PF01679 Pmp3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQAE_ECOLI UPF0057 membrane protein YqaE # RefSeq NP_417152 NC_000913.3 # RefSeq WP_000508177 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0057 (PMP3) family. {ECO 0000305}. # SUBCELLULAR LOCATION YQAE_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # TCDB 9.B.12.2 the sensitivity to sodium or salt stress-induced hydrophobic peptide (sna) family # eggNOG COG0401 LUCA # eggNOG ENOG4105VPI Bacteria BLAST swissprot:YQAE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQAE_ECOLI BioCyc ECOL316407:JW2641-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2641-MONOMER BioCyc EcoCyc:G7396-MONOMER http://biocyc.org/getid?id=EcoCyc:G7396-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4060 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4060 EcoGene EG14313 http://www.ecogene.org/geneInfo.php?eg_id=EG14313 EnsemblBacteria AAC75713 http://www.ensemblgenomes.org/id/AAC75713 EnsemblBacteria AAC75713 http://www.ensemblgenomes.org/id/AAC75713 EnsemblBacteria BAA16529 http://www.ensemblgenomes.org/id/BAA16529 EnsemblBacteria BAA16529 http://www.ensemblgenomes.org/id/BAA16529 EnsemblBacteria BAA16529 http://www.ensemblgenomes.org/id/BAA16529 EnsemblBacteria b2666 http://www.ensemblgenomes.org/id/b2666 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 947138 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947138 HOGENOM HOG000274029 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000274029&db=HOGENOM6 InParanoid P0AE42 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AE42 InterPro IPR000612 http://www.ebi.ac.uk/interpro/entry/IPR000612 KEGG_Gene ecj:JW2641 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2641 KEGG_Gene eco:b2666 http://www.genome.jp/dbget-bin/www_bget?eco:b2666 OMA MELIRII http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MELIRII PANTHER PTHR21659 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21659 PROSITE PS01309 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01309 PSORT swissprot:YQAE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQAE_ECOLI PSORT-B swissprot:YQAE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQAE_ECOLI PSORT2 swissprot:YQAE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQAE_ECOLI Pfam PF01679 http://pfam.xfam.org/family/PF01679 Phobius swissprot:YQAE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQAE_ECOLI PhylomeDB P0AE42 http://phylomedb.org/?seqid=P0AE42 ProteinModelPortal P0AE42 http://www.proteinmodelportal.org/query/uniprot/P0AE42 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417152 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417152 RefSeq WP_000508177 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000508177 STRING 511145.b2666 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2666&targetmode=cogs TCDB 9.B.12.2 http://www.tcdb.org/search/result.php?tc=9.B.12.2 UniProtKB YQAE_ECOLI http://www.uniprot.org/uniprot/YQAE_ECOLI UniProtKB-AC P0AE42 http://www.uniprot.org/uniprot/P0AE42 charge swissprot:YQAE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQAE_ECOLI eggNOG COG0401 http://eggnogapi.embl.de/nog_data/html/tree/COG0401 eggNOG ENOG4105VPI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VPI epestfind swissprot:YQAE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQAE_ECOLI garnier swissprot:YQAE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQAE_ECOLI helixturnhelix swissprot:YQAE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQAE_ECOLI hmoment swissprot:YQAE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQAE_ECOLI iep swissprot:YQAE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQAE_ECOLI inforesidue swissprot:YQAE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQAE_ECOLI octanol swissprot:YQAE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQAE_ECOLI pepcoil swissprot:YQAE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQAE_ECOLI pepdigest swissprot:YQAE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQAE_ECOLI pepinfo swissprot:YQAE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQAE_ECOLI pepnet swissprot:YQAE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQAE_ECOLI pepstats swissprot:YQAE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQAE_ECOLI pepwheel swissprot:YQAE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQAE_ECOLI pepwindow swissprot:YQAE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQAE_ECOLI sigcleave swissprot:YQAE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQAE_ECOLI ## Database ID URL or Descriptions # BioGrid 4263514 19 # EcoGene EG12974 ygfI # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IBA:GO_Central. # GO_process GO:0006351 transcription, DNA-templated; ISS:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IBA:GO_Central. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR005119 LysR_subst-bd # InterPro IPR011991 WHTH_DNA-bd_dom # Organism YGFI_ECOLI Escherichia coli (strain K12) # PATRIC 32121256 VBIEscCol129921_3016 # PIR H65076 H65076 # PROSITE PS50931 HTH_LYSR # Pfam PF00126 HTH_1 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGFI_ECOLI Uncharacterized HTH-type transcriptional regulator YgfI # RefSeq NP_417396 NC_000913.3 # RefSeq WP_000350807 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA69088.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Contains 1 HTH lysR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00253}. # SUPFAM SSF46785 SSF46785 # eggNOG ENOG4105DEQ Bacteria # eggNOG ENOG410XPUX LUCA BLAST swissprot:YGFI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGFI_ECOLI BioCyc ECOL316407:JW5476-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5476-MONOMER BioCyc EcoCyc:G7518-MONOMER http://biocyc.org/getid?id=EcoCyc:G7518-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2801 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2801 EcoGene EG12974 http://www.ecogene.org/geneInfo.php?eg_id=EG12974 EnsemblBacteria AAC75958 http://www.ensemblgenomes.org/id/AAC75958 EnsemblBacteria AAC75958 http://www.ensemblgenomes.org/id/AAC75958 EnsemblBacteria BAE76985 http://www.ensemblgenomes.org/id/BAE76985 EnsemblBacteria BAE76985 http://www.ensemblgenomes.org/id/BAE76985 EnsemblBacteria BAE76985 http://www.ensemblgenomes.org/id/BAE76985 EnsemblBacteria b2921 http://www.ensemblgenomes.org/id/b2921 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 947401 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947401 HOGENOM HOG000124391 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000124391&db=HOGENOM6 InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW5476 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5476 KEGG_Gene eco:b2921 http://www.genome.jp/dbget-bin/www_bget?eco:b2921 OMA AMLDAYM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AMLDAYM PROSITE PS50931 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50931 PSORT swissprot:YGFI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGFI_ECOLI PSORT-B swissprot:YGFI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGFI_ECOLI PSORT2 swissprot:YGFI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGFI_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:YGFI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGFI_ECOLI PhylomeDB P52044 http://phylomedb.org/?seqid=P52044 ProteinModelPortal P52044 http://www.proteinmodelportal.org/query/uniprot/P52044 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417396 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417396 RefSeq WP_000350807 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000350807 SMR P52044 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P52044 STRING 511145.b2921 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2921&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB YGFI_ECOLI http://www.uniprot.org/uniprot/YGFI_ECOLI UniProtKB-AC P52044 http://www.uniprot.org/uniprot/P52044 charge swissprot:YGFI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGFI_ECOLI eggNOG ENOG4105DEQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DEQ eggNOG ENOG410XPUX http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPUX epestfind swissprot:YGFI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGFI_ECOLI garnier swissprot:YGFI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGFI_ECOLI helixturnhelix swissprot:YGFI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGFI_ECOLI hmoment swissprot:YGFI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGFI_ECOLI iep swissprot:YGFI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGFI_ECOLI inforesidue swissprot:YGFI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGFI_ECOLI octanol swissprot:YGFI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGFI_ECOLI pepcoil swissprot:YGFI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGFI_ECOLI pepdigest swissprot:YGFI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGFI_ECOLI pepinfo swissprot:YGFI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGFI_ECOLI pepnet swissprot:YGFI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGFI_ECOLI pepstats swissprot:YGFI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGFI_ECOLI pepwheel swissprot:YGFI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGFI_ECOLI pepwindow swissprot:YGFI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGFI_ECOLI sigcleave swissprot:YGFI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGFI_ECOLI ## Database ID URL or Descriptions # BioGrid 4261582 279 # CDD cd09719 Cas1_I-E # COFACTOR CAS1_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 21219465, ECO 0000269|PubMed 25707795, ECO 0000269|PubMed 26284603}; Note=Protospacer integration in vitro also occurs with Mn(2+) and also requires low concentrations of KCl (PubMed 25707795). The transesterification function works equally well with Mg(2+), Mn(2+) or Co(2+) in vitro (PubMed 26284603). {ECO 0000269|PubMed 25707795, ECO 0000269|PubMed 26284603}; # DISRUPTION PHENOTYPE CAS1_ECOLI Not essential. Increased sensitivity to MMC and UV light; double ygbT-ruvA, ruvB or ruvC disruptions have no further phenotype suggesting Cas1 functions in the same DNA repair pathway (PubMed 21219465). Function in DNA repair also seems to require CRISPRs (PubMed 21219465). Cells elongate after 2 hours growth in MMC; they are even longer in double ygbT-ruvA, ruvB or ruvC disruptions, suggesting Cas1 may also function in chromosome segregation (PubMed 21219465). Loss of plasmid silencing (PubMed 21255106). {ECO 0000269|PubMed 21219465, ECO 0000269|PubMed 21255106}. # DOMAIN CAS1_ECOLI Substrate DNA-binding induces large structural changes that generate a surface for DNA-binding across the Cas2 dimer and formation of an optimal catalytic site (PubMed 26478180). {ECO 0000269|PubMed 26478180}. # ENZYME REGULATION Nuclease activity partially inhibited by CasE (PubMed:21219465). {ECO 0000269|PubMed:21219465}. # EcoGene EG13114 ygbT # FUNCTION CAS1_ECOLI CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids) (PubMed 21255106, PubMed 24920831, PubMed 24793649). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). The Cas1-Cas2 complex is involved in CRISPR adaptation, the first stage of CRISPR immunity, being required for the addition/removal of CRISPR spacers at the leader end of the CRISPR locus (PubMed 24920831, PubMed 25707795, PubMed 24793649). The Cas1-Cas2 complex introduces staggered nicks into both strands of the CRISPR array near the leader repeat and joins the 5'-ends of the repeat strands with the 3'-ends of the new spacer sequence (PubMed 24920831). Spacer DNA integration requires supercoiled target DNA and 3'-OH ends on the inserted (spacer) DNA and probably initiates with a nucleophilic attack of the C 3'-OH end of the protospacer on the minus strand of the first repeat sequence (PubMed 25707795). Expression of Cas1-Cas2 in a strain lacking both genes permits spacer acquisition (PubMed 24793649, PubMed 24920831). Non-specifically binds DNA; the Cas1-Cas2 complex preferentially binds CRISPR-locus DNA (PubMed 24793649). Highest binding is seen to a dual forked DNA complex with 3'-overhangs and a protospacer-adjacent motif- complement specifically positioned (PubMed 26478180). The protospacer DNA lies across a flat surface extending from 1 Cas1 dimer, across the Cas2 dimer and contacting the other Cas1 dimer; the 23 bp-long ds section of the DNA is bracketed by 1 Tyr-22 from each of the Cas1 dimers (PubMed 26478180, PubMed 26503043). Cas1 cuts within the 3'-overhang, to generate a 33-nucleotide DNA that is probably incorporated into the CRISPR leader by a cut-and-paste mechanism (PubMed 26478180). Cas1 alone endonucleolytically cleaves linear ssRNA, ssDNA and short (34 base) dsDNA as well as branched DNA substrates such as Holliday junctions, replication forks and 5'-flap DNA substrates (PubMed 21219465). In vitro catalyzes a concerted transesterification reaction on branched DNA, as would be expected during integration of protospacers into the CRISPR leader sequence; Cas2 is not required in vitro. This reaction requires a 3'-OH group at the branch point (PubMed 26284603). Genetic interactions suggest Cas1 interacts with components of the RecBC and RuvB DNA repair systems (PubMed 21219465). {ECO 0000269|PubMed 21219465, ECO 0000269|PubMed 21255106, ECO 0000269|PubMed 24793649, ECO 0000269|PubMed 24920831, ECO 0000269|PubMed 25707795, ECO 0000269|PubMed 26284603, ECO 0000269|PubMed 26478180}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0008821 crossover junction endodeoxyribonuclease activity; IDA:EcoCyc. # GO_function GO:0017108 5'-flap endonuclease activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006281 DNA repair; IEA:UniProtKB-KW. # GO_process GO:0006974 cellular response to DNA damage stimulus; IMP:EcoCyc. # GO_process GO:0043571 maintenance of CRISPR repeat elements; IMP:EcoCyc. # GO_process GO:0051607 defense response to virus; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004518 nuclease activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0002376 immune system process # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0044403 symbiosis, encompassing mutualism through parasitism # GOslim_process GO:0051276 chromosome organization # HAMAP MF_01470 Cas1 # INDUCTION CAS1_ECOLI Repressed by H-NS (PubMed 20132443). Activated by LeuO (PubMed 19429622). Activated by the BaeSR two-component regulatory system, possibly due to envelope stress (PubMed 21255106). Part of the casABCDE-ygbT-ygbF operon (PubMed 19429622). {ECO 0000269|PubMed 19429622, ECO 0000269|PubMed 20132443, ECO 0000269|PubMed 21255106}. # INTERACTION CAS1_ECOLI P76339 yedV; NbExp=3; IntAct=EBI-1130209, EBI-554869; # IntAct Q46896 15 # InterPro IPR002729 CRISPR-assoc_Cas1 # InterPro IPR019851 CRISPR-assoc_Cas1_ECOLI # InterPro IPR033641 Cas1_I-E # KEGG_Brite ko03400 DNA repair and recombination proteins # Organism CAS1_ECOLI Escherichia coli (strain K12) # PATRIC 32120920 VBIEscCol129921_2852 # PDB 3NKD X-ray; 1.95 A; A/B=1-305 # PDB 3NKE X-ray; 1.40 A; A/B/C=92-291 # PDB 4P6I X-ray; 2.30 A; C/D/E/F=1-305 # PDB 4QDL X-ray; 2.70 A; A/B/C/D=1-305 # PDB 5DLJ X-ray; 2.60 A; A/B/C/D=2-281 # PDB 5DQT X-ray; 3.10 A; A/B/C/D/I/J/K/L=1-305 # PDB 5DQU X-ray; 4.50 A; A/B/C/D=1-305 # PDB 5DQZ X-ray; 2.70 A; A/B/C/D=1-305 # PDB 5DS4 X-ray; 3.20 A; A/B/C/D=1-305 # PDB 5DS5 X-ray; 2.95 A; A/B/C/D=1-305 # PDB 5DS6 X-ray; 3.35 A; A/B/C/D=1-305 # PIR G65056 G65056 # Pfam PF01867 Cas_Cas1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CAS1_ECOLI CRISPR-associated endonuclease Cas1 # RefSeq NP_417235 NC_000913.3 # RefSeq WP_000220066 NZ_LN832404.1 # SIMILARITY Belongs to the CRISPR-associated endonuclease Cas1 family. {ECO 0000305}. # SUBCELLULAR LOCATION CAS1_ECOLI Cytoplasm {ECO 0000269|PubMed 21219465}. Note=In 15% of cell localizes to discrete nucleoid foci (probable DNA damage sites) upon treatment with mitomycin C (MMC) for 2 hours (PubMed 21219465). {ECO 0000269|PubMed 21219465}. # SUBUNIT CAS1_ECOLI Homodimer (PubMed 21219465). Part of the Cas1-Cas2 complex (PubMed 24920831, PubMed 24793649, PubMed 25707795, Ref.11, PubMed 26478180, PubMed 26503043). Interacts with RecB, RecC, RuvB, CasC and CasE (PubMed 21219465). Forms a hexamer with 2 Cas1 dimers sandwiching a Cas2 dimer (PubMed 24793649, PubMed 26478180). The DNA lies across a flat surface extending from 1 Cas1 dimer, across the Cas2 dimer and contacting the other Cas1 dimer. Only 1 Cas1 protein from each dimer is catalytic, the other interacts with the Cas2 dimer and possibly target DNA (PubMed 26478180, PubMed 26503043). {ECO 0000269|PubMed 21219465, ECO 0000269|PubMed 24793649, ECO 0000269|PubMed 24920831, ECO 0000269|PubMed 25707795, ECO 0000269|PubMed 26478180, ECO 0000269|PubMed 26503043, ECO 0000305|Ref.11}. # TIGRFAMs TIGR00287 cas1; 2 # TIGRFAMs TIGR03638 cas1_ECOLI # eggNOG COG1518 LUCA # eggNOG ENOG4105TZK Bacteria BLAST swissprot:CAS1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CAS1_ECOLI BioCyc ECOL316407:JW2725-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2725-MONOMER BioCyc EcoCyc:G7425-MONOMER http://biocyc.org/getid?id=EcoCyc:G7425-MONOMER COG COG1518 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1518 DIP DIP-12118N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12118N DOI 10.1016/j.cell.2015.10.008 http://dx.doi.org/10.1016/j.cell.2015.10.008 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature14237 http://dx.doi.org/10.1038/nature14237 DOI 10.1038/nature15760 http://dx.doi.org/10.1038/nature15760 DOI 10.1038/nsmb.2820 http://dx.doi.org/10.1038/nsmb.2820 DOI 10.1093/nar/gku510 http://dx.doi.org/10.1093/nar/gku510 DOI 10.1111/j.1365-2958.2010.07073.x http://dx.doi.org/10.1111/j.1365-2958.2010.07073.x DOI 10.1111/j.1365-2958.2010.07465.x http://dx.doi.org/10.1111/j.1365-2958.2010.07465.x DOI 10.1111/j.1365-2958.2010.07482.x http://dx.doi.org/10.1111/j.1365-2958.2010.07482.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00108-09 http://dx.doi.org/10.1128/JB.00108-09 DOI 10.7554/eLife.08716 http://dx.doi.org/10.7554/eLife.08716 EC_number EC:3.1.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 ENZYME 3.1.-.- http://enzyme.expasy.org/EC/3.1.-.- EchoBASE EB2915 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2915 EcoGene EG13114 http://www.ecogene.org/geneInfo.php?eg_id=EG13114 EnsemblBacteria AAC75797 http://www.ensemblgenomes.org/id/AAC75797 EnsemblBacteria AAC75797 http://www.ensemblgenomes.org/id/AAC75797 EnsemblBacteria BAE76832 http://www.ensemblgenomes.org/id/BAE76832 EnsemblBacteria BAE76832 http://www.ensemblgenomes.org/id/BAE76832 EnsemblBacteria BAE76832 http://www.ensemblgenomes.org/id/BAE76832 EnsemblBacteria b2755 http://www.ensemblgenomes.org/id/b2755 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0008821 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008821 GO_function GO:0017108 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017108 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006281 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0043571 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043571 GO_process GO:0051607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051607 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0002376 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0044403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403 GOslim_process GO:0051276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051276 GeneID 947228 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947228 HAMAP MF_01470 http://hamap.expasy.org/unirule/MF_01470 HOGENOM HOG000015862 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000015862&db=HOGENOM6 InParanoid Q46896 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46896 IntAct Q46896 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46896* IntEnz 3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1 InterPro IPR002729 http://www.ebi.ac.uk/interpro/entry/IPR002729 InterPro IPR019851 http://www.ebi.ac.uk/interpro/entry/IPR019851 InterPro IPR033641 http://www.ebi.ac.uk/interpro/entry/IPR033641 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW2725 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2725 KEGG_Gene eco:b2755 http://www.genome.jp/dbget-bin/www_bget?eco:b2755 KEGG_Orthology KO:K15342 http://www.genome.jp/dbget-bin/www_bget?KO:K15342 OMA IGDAGHR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IGDAGHR PDB 3NKD http://www.ebi.ac.uk/pdbe-srv/view/entry/3NKD PDB 3NKE http://www.ebi.ac.uk/pdbe-srv/view/entry/3NKE PDB 4P6I http://www.ebi.ac.uk/pdbe-srv/view/entry/4P6I PDB 4QDL http://www.ebi.ac.uk/pdbe-srv/view/entry/4QDL PDB 5DLJ http://www.ebi.ac.uk/pdbe-srv/view/entry/5DLJ PDB 5DQT http://www.ebi.ac.uk/pdbe-srv/view/entry/5DQT PDB 5DQU http://www.ebi.ac.uk/pdbe-srv/view/entry/5DQU PDB 5DQZ http://www.ebi.ac.uk/pdbe-srv/view/entry/5DQZ PDB 5DS4 http://www.ebi.ac.uk/pdbe-srv/view/entry/5DS4 PDB 5DS5 http://www.ebi.ac.uk/pdbe-srv/view/entry/5DS5 PDB 5DS6 http://www.ebi.ac.uk/pdbe-srv/view/entry/5DS6 PDBsum 3NKD http://www.ebi.ac.uk/pdbsum/3NKD PDBsum 3NKE http://www.ebi.ac.uk/pdbsum/3NKE PDBsum 4P6I http://www.ebi.ac.uk/pdbsum/4P6I PDBsum 4QDL http://www.ebi.ac.uk/pdbsum/4QDL PDBsum 5DLJ http://www.ebi.ac.uk/pdbsum/5DLJ PDBsum 5DQT http://www.ebi.ac.uk/pdbsum/5DQT PDBsum 5DQU http://www.ebi.ac.uk/pdbsum/5DQU PDBsum 5DQZ http://www.ebi.ac.uk/pdbsum/5DQZ PDBsum 5DS4 http://www.ebi.ac.uk/pdbsum/5DS4 PDBsum 5DS5 http://www.ebi.ac.uk/pdbsum/5DS5 PDBsum 5DS6 http://www.ebi.ac.uk/pdbsum/5DS6 PSORT swissprot:CAS1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CAS1_ECOLI PSORT-B swissprot:CAS1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CAS1_ECOLI PSORT2 swissprot:CAS1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CAS1_ECOLI Pfam PF01867 http://pfam.xfam.org/family/PF01867 Phobius swissprot:CAS1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CAS1_ECOLI ProteinModelPortal Q46896 http://www.proteinmodelportal.org/query/uniprot/Q46896 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19429622 http://www.ncbi.nlm.nih.gov/pubmed/19429622 PubMed 20132443 http://www.ncbi.nlm.nih.gov/pubmed/20132443 PubMed 21219465 http://www.ncbi.nlm.nih.gov/pubmed/21219465 PubMed 21255106 http://www.ncbi.nlm.nih.gov/pubmed/21255106 PubMed 24793649 http://www.ncbi.nlm.nih.gov/pubmed/24793649 PubMed 24920831 http://www.ncbi.nlm.nih.gov/pubmed/24920831 PubMed 25707795 http://www.ncbi.nlm.nih.gov/pubmed/25707795 PubMed 26284603 http://www.ncbi.nlm.nih.gov/pubmed/26284603 PubMed 26478180 http://www.ncbi.nlm.nih.gov/pubmed/26478180 PubMed 26503043 http://www.ncbi.nlm.nih.gov/pubmed/26503043 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417235 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417235 RefSeq WP_000220066 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000220066 SMR Q46896 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46896 STRING 511145.b2755 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2755&targetmode=cogs STRING COG1518 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1518&targetmode=cogs TIGRFAMs TIGR00287 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00287 TIGRFAMs TIGR03638 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03638 UniProtKB CAS1_ECOLI http://www.uniprot.org/uniprot/CAS1_ECOLI UniProtKB-AC Q46896 http://www.uniprot.org/uniprot/Q46896 charge swissprot:CAS1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CAS1_ECOLI eggNOG COG1518 http://eggnogapi.embl.de/nog_data/html/tree/COG1518 eggNOG ENOG4105TZK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105TZK epestfind swissprot:CAS1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CAS1_ECOLI garnier swissprot:CAS1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CAS1_ECOLI helixturnhelix swissprot:CAS1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CAS1_ECOLI hmoment swissprot:CAS1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CAS1_ECOLI iep swissprot:CAS1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CAS1_ECOLI inforesidue swissprot:CAS1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CAS1_ECOLI octanol swissprot:CAS1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CAS1_ECOLI pepcoil swissprot:CAS1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CAS1_ECOLI pepdigest swissprot:CAS1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CAS1_ECOLI pepinfo swissprot:CAS1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CAS1_ECOLI pepnet swissprot:CAS1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CAS1_ECOLI pepstats swissprot:CAS1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CAS1_ECOLI pepwheel swissprot:CAS1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CAS1_ECOLI pepwindow swissprot:CAS1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CAS1_ECOLI sigcleave swissprot:CAS1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CAS1_ECOLI ## Database ID URL or Descriptions # AltName Quinone oxidoreductase KefF {ECO:0000255|HAMAP-Rule MF_01414} # BioGrid 4262201 9 # CATALYTIC ACTIVITY KEFF_ECOLI NAD(P)H + a quinone = NAD(P)(+) + a hydroquinone. {ECO 0000255|HAMAP-Rule MF_01414, ECO 0000269|PubMed 21742892}. # COFACTOR KEFF_ECOLI Name=FMN; Xref=ChEBI CHEBI 58210; Evidence={ECO 0000255|HAMAP-Rule MF_01414, ECO 0000269|PubMed 21742892}; # EcoGene EG11568 kefF # FUNCTION KEFF_ECOLI Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefC. Shows redox enzymatic activity, but this enzymatic activity is not required for activation of KefC. Can use a wide range of substrates, including electrophilic quinones, and its function could be to reduce the redox toxicity of electrophilic quinones in parallel with acting as triggers for the KefC efflux system. {ECO 0000255|HAMAP-Rule MF_01414, ECO 0000269|PubMed 11053405, ECO 0000269|PubMed 19523906, ECO 0000269|PubMed 21742892}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_function GO:0003955 NAD(P)H dehydrogenase (quinone) activity; IDA:EcoCyc. # GO_function GO:0009055 electron carrier activity; IMP:EcoliWiki. # GO_function GO:0010181 FMN binding; IDA:EcoCyc. # GO_process GO:0006813 potassium ion transport; IEA:InterPro. # GO_process GO:0032414 positive regulation of ion transmembrane transporter activity; IDA:EcoCyc. # GO_process GO:1901381 positive regulation of potassium ion transmembrane transport; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.360 -; 1. # HAMAP MF_01414 K_H_efflux_KefF # IntAct P0A754 6 # InterPro IPR003680 Flavodoxin_fold # InterPro IPR023948 K_H_efflux_KefF # InterPro IPR029039 Flavoprotein-like_dom # Organism KEFF_ECOLI Escherichia coli (strain K12) # PATRIC 32115191 VBIEscCol129921_0047 # PDB 3EYW X-ray; 2.40 A; A/B=1-176 # PDB 3L9W X-ray; 1.75 A; A/B=1-176 # PDB 3L9X X-ray; 2.10 A; A/B=1-176 # PIR F64725 F64725 # Pfam PF02525 Flavodoxin_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Glutathione-regulated potassium-efflux system ancillary protein KefF {ECO:0000255|HAMAP-Rule MF_01414} # RefSeq NP_414588 NC_000913.3 # RefSeq WP_000600725 NZ_LN832404.1 # SIMILARITY Belongs to the NAD(P)H dehydrogenase (quinone) family. KefF subfamily. {ECO:0000255|HAMAP-Rule MF_01414}. # SUBCELLULAR LOCATION KEFF_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01414}; Peripheral membrane protein {ECO 0000255|HAMAP- Rule MF_01414}; Cytoplasmic side {ECO 0000255|HAMAP- Rule MF_01414}. # SUBUNIT KEFF_ECOLI Homodimer. Interacts with KefC, forming a heterotetramer with 2 2 stoichiometry. {ECO 0000255|HAMAP-Rule MF_01414, ECO 0000269|PubMed 17679694, ECO 0000269|PubMed 19523906, ECO 0000269|PubMed 21041667, ECO 0000269|PubMed 21742892}. # SUPFAM SSF52218 SSF52218 # TCDB 2.A.37.1:the monovalent cation proton antiporter-2 (cpa2) family # eggNOG COG2249 LUCA # eggNOG ENOG4108MXQ Bacteria BLAST swissprot:KEFF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:KEFF_ECOLI BioCyc ECOL316407:JW0045-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0045-MONOMER BioCyc EcoCyc:EG11568-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11568-MONOMER BioCyc MetaCyc:EG11568-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11568-MONOMER COG COG2249 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2249 DIP DIP-35822N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35822N DOI 10.1016/j.str.2009.03.018 http://dx.doi.org/10.1016/j.str.2009.03.018 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0703709104 http://dx.doi.org/10.1073/pnas.0703709104 DOI 10.1073/pnas.1012716107 http://dx.doi.org/10.1073/pnas.1012716107 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.05272-11 http://dx.doi.org/10.1128/JB.05272-11 DOI 10.1128/JB.182.22.6536-6540.2000 http://dx.doi.org/10.1128/JB.182.22.6536-6540.2000 EC_number EC:1.6.5.2 {ECO:0000255|HAMAP-Rule:MF_01414} http://www.genome.jp/dbget-bin/www_bget?EC:1.6.5.2 {ECO:0000255|HAMAP-Rule:MF_01414} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.6.5.2 {ECO:0000255|HAMAP-Rule:MF_01414} http://enzyme.expasy.org/EC/1.6.5.2 {ECO:0000255|HAMAP-Rule:MF_01414} EchoBASE EB1528 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1528 EcoGene EG11568 http://www.ecogene.org/geneInfo.php?eg_id=EG11568 EnsemblBacteria AAC73157 http://www.ensemblgenomes.org/id/AAC73157 EnsemblBacteria AAC73157 http://www.ensemblgenomes.org/id/AAC73157 EnsemblBacteria BAB96614 http://www.ensemblgenomes.org/id/BAB96614 EnsemblBacteria BAB96614 http://www.ensemblgenomes.org/id/BAB96614 EnsemblBacteria BAB96614 http://www.ensemblgenomes.org/id/BAB96614 EnsemblBacteria b0046 http://www.ensemblgenomes.org/id/b0046 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0003955 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003955 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0010181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010181 GO_process GO:0006813 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813 GO_process GO:0032414 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032414 GO_process GO:1901381 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901381 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.360 http://www.cathdb.info/version/latest/superfamily/3.40.50.360 GeneID 944767 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944767 HAMAP MF_01414 http://hamap.expasy.org/unirule/MF_01414 HOGENOM HOG000149972 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000149972&db=HOGENOM6 InParanoid P0A754 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A754 IntAct P0A754 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A754* IntEnz 1.6.5.2 {ECO:0000255|HAMAP-Rule:MF_01414} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.6.5.2 {ECO:0000255|HAMAP-Rule:MF_01414} InterPro IPR003680 http://www.ebi.ac.uk/interpro/entry/IPR003680 InterPro IPR023948 http://www.ebi.ac.uk/interpro/entry/IPR023948 InterPro IPR029039 http://www.ebi.ac.uk/interpro/entry/IPR029039 KEGG_Gene ecj:JW0045 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0045 KEGG_Gene eco:b0046 http://www.genome.jp/dbget-bin/www_bget?eco:b0046 KEGG_Orthology KO:K11746 http://www.genome.jp/dbget-bin/www_bget?KO:K11746 OMA VNADTEH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VNADTEH PDB 3EYW http://www.ebi.ac.uk/pdbe-srv/view/entry/3EYW PDB 3L9W http://www.ebi.ac.uk/pdbe-srv/view/entry/3L9W PDB 3L9X http://www.ebi.ac.uk/pdbe-srv/view/entry/3L9X PDBsum 3EYW http://www.ebi.ac.uk/pdbsum/3EYW PDBsum 3L9W http://www.ebi.ac.uk/pdbsum/3L9W PDBsum 3L9X http://www.ebi.ac.uk/pdbsum/3L9X PSORT swissprot:KEFF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:KEFF_ECOLI PSORT-B swissprot:KEFF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:KEFF_ECOLI PSORT2 swissprot:KEFF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:KEFF_ECOLI Pfam PF02525 http://pfam.xfam.org/family/PF02525 Phobius swissprot:KEFF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:KEFF_ECOLI PhylomeDB P0A754 http://phylomedb.org/?seqid=P0A754 ProteinModelPortal P0A754 http://www.proteinmodelportal.org/query/uniprot/P0A754 PubMed 11053405 http://www.ncbi.nlm.nih.gov/pubmed/11053405 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17679694 http://www.ncbi.nlm.nih.gov/pubmed/17679694 PubMed 19523906 http://www.ncbi.nlm.nih.gov/pubmed/19523906 PubMed 21041667 http://www.ncbi.nlm.nih.gov/pubmed/21041667 PubMed 21742892 http://www.ncbi.nlm.nih.gov/pubmed/21742892 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414588 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414588 RefSeq WP_000600725 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000600725 SMR P0A754 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A754 STRING 511145.b0046 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0046&targetmode=cogs STRING COG2249 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2249&targetmode=cogs SUPFAM SSF52218 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52218 TCDB 2.A.37.1 http://www.tcdb.org/search/result.php?tc=2.A.37.1 UniProtKB KEFF_ECOLI http://www.uniprot.org/uniprot/KEFF_ECOLI UniProtKB-AC P0A754 http://www.uniprot.org/uniprot/P0A754 charge swissprot:KEFF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:KEFF_ECOLI eggNOG COG2249 http://eggnogapi.embl.de/nog_data/html/tree/COG2249 eggNOG ENOG4108MXQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MXQ epestfind swissprot:KEFF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:KEFF_ECOLI garnier swissprot:KEFF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:KEFF_ECOLI helixturnhelix swissprot:KEFF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:KEFF_ECOLI hmoment swissprot:KEFF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:KEFF_ECOLI iep swissprot:KEFF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:KEFF_ECOLI inforesidue swissprot:KEFF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:KEFF_ECOLI octanol swissprot:KEFF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:KEFF_ECOLI pepcoil swissprot:KEFF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:KEFF_ECOLI pepdigest swissprot:KEFF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:KEFF_ECOLI pepinfo swissprot:KEFF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:KEFF_ECOLI pepnet swissprot:KEFF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:KEFF_ECOLI pepstats swissprot:KEFF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:KEFF_ECOLI pepwheel swissprot:KEFF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:KEFF_ECOLI pepwindow swissprot:KEFF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:KEFF_ECOLI sigcleave swissprot:KEFF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:KEFF_ECOLI ## Database ID URL or Descriptions # AltName Biotin operon repressor {ECO:0000255|HAMAP-Rule MF_00978} # AltName Biotin--[acetyl-CoA-carboxylase] ligase {ECO:0000255|HAMAP-Rule MF_00978} # AltName Biotin--protein ligase {ECO:0000255|HAMAP-Rule MF_00978} # AltName Biotin-[acetyl-CoA carboxylase] synthetase {ECO:0000255|HAMAP-Rule MF_00978} # BRENDA 6.3.4.15 2026 # BioGrid 4263391 269 # CATALYTIC ACTIVITY BIRA_ECOLI ATP + biotin + apo-[acetyl-CoA carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [acetyl-CoA carbon- dioxide ligase (ADP-forming)]. {ECO 0000255|HAMAP-Rule MF_00978, ECO 0000269|PubMed 6129246, ECO 0000269|PubMed 8003500}. # DOMAIN BIRA_ECOLI Contains an N-terminal helix-turn-helix DNA-binding domain, connected via a linker to the central catalytic domain and the C-terminal domain, which plays roles in dimerization, catalytic function and DNA binding. The N-terminal domain is required for both ligase and repressor activities. It may orient the active site and thereby play an important role in enzymatic activity. {ECO 0000269|PubMed 11353844, ECO 0000269|PubMed 1409631, ECO 0000269|PubMed 16438984, ECO 0000269|PubMed 24189073}. # ENZYME REGULATION The switch between the enzymatic activity and the repressor activity is regulated by cellular demand for biotin. The switch occurs by swapping of protein interaction partners by holoBirA. In conditions of high biotin demand, holoBirA associates with apoBCCP to transfer biotin. In conditions of low biotin demand, holoBirA dimerizes, binds DNA and represses transcription of the biotin operon. {ECO:0000269|PubMed 23896299}. # EcoGene EG10123 birA # FUNCTION BIRA_ECOLI Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. {ECO 0000255|HAMAP- Rule MF_00978, ECO 0000269|PubMed 12527300, ECO 0000269|PubMed 2667763, ECO 0000269|PubMed 6129246, ECO 0000269|PubMed 8003500}. # GO_function GO:0003677 DNA binding; IDA:EcoliWiki. # GO_function GO:0004077 biotin-[acetyl-CoA-carboxylase] ligase activity; IDA:EcoliWiki. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-HAMAP. # GO_process GO:0009102 biotin biosynthetic process; IMP:EcoliWiki. # GO_process GO:0009305 protein biotinylation; IDA:CACAO. # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 1.10.10.10 -; 1. # HAMAP MF_00978 Bifunct_BirA # IntAct P06709 7 # InterPro IPR003142 BPL_C # InterPro IPR004143 BPL_LPL_catalytic # InterPro IPR004408 Biotin_CoA_COase_ligase # InterPro IPR004409 Biotin_operon_repress_HTH # InterPro IPR008988 Transcriptional_repressor_C # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR013196 HTH_11 # InterPro IPR030855 Bifunct_BirA # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03000 Transcription factors # KEGG_Pathway ko00780 Biotin metabolism # Organism BIRA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR12835 PTHR12835 # PATRIC 32123467 VBIEscCol129921_4090 # PDB 1BIA X-ray; 2.30 A; A=1-321 # PDB 1BIB X-ray; 2.80 A; A=1-321 # PDB 1HXD X-ray; 2.40 A; A/B=1-321 # PDB 1K67 Model; -; A=65-317 # PDB 2EWN X-ray; 2.80 A; A/B=1-321 # PDB 4WF2 X-ray; 2.31 A; A=1-321 # PIR B24029 BVECBF # PROSITE PS51733 BPL_LPL_CATALYTIC # Pfam PF02237 BPL_C # Pfam PF03099 BPL_LplA_LipB # Pfam PF08279 HTH_11 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Bifunctional ligase/repressor BirA {ECO:0000255|HAMAP-Rule MF_00978} # RefSeq NP_418404 NC_000913.3 # RefSeq WP_000654630 NZ_LN832404.1 # SIMILARITY Belongs to the biotin--protein ligase family. {ECO:0000255|HAMAP-Rule MF_00978}. # SIMILARITY Contains 1 BPL/LPL catalytic domain. {ECO:0000255|PROSITE-ProRule PRU01067}. # SUBUNIT BIRA_ECOLI Monomer in solution. Interacts with BCCP. Homodimerizes to bind DNA. Interaction with the corepressor bio-5'-AMP increases dimerization. {ECO 0000269|PubMed 11353844, ECO 0000269|PubMed 12527300, ECO 0000269|PubMed 1409631, ECO 0000269|PubMed 16438984, ECO 0000269|PubMed 23896299, ECO 0000269|PubMed 6129246}. # SUPFAM SSF46785 SSF46785 # SUPFAM SSF50037 SSF50037 # TIGRFAMs TIGR00121 birA_ligase # TIGRFAMs TIGR00122 birA_repr_reg # eggNOG COG0340 LUCA # eggNOG COG1654 LUCA # eggNOG ENOG4105HJX Bacteria BLAST swissprot:BIRA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BIRA_ECOLI BioCyc ECOL316407:JW3941-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3941-MONOMER BioCyc EcoCyc:BIOTINLIG-MONOMER http://biocyc.org/getid?id=EcoCyc:BIOTINLIG-MONOMER BioCyc MetaCyc:BIOTINLIG-MONOMER http://biocyc.org/getid?id=MetaCyc:BIOTINLIG-MONOMER COG COG0340 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0340 COG COG1654 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1654 DIP DIP-9224N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9224N DOI 10.1016/0092-8674(89)90421-2 http://dx.doi.org/10.1016/0092-8674(89)90421-2 DOI 10.1016/0378-1119(85)90011-3 http://dx.doi.org/10.1016/0378-1119(85)90011-3 DOI 10.1016/0378-1119(86)90189-7 http://dx.doi.org/10.1016/0378-1119(86)90189-7 DOI 10.1016/S0022-2836(02)01308-6 http://dx.doi.org/10.1016/S0022-2836(02)01308-6 DOI 10.1016/j.jmb.2005.12.066 http://dx.doi.org/10.1016/j.jmb.2005.12.066 DOI 10.1016/j.jmb.2013.07.029 http://dx.doi.org/10.1016/j.jmb.2013.07.029 DOI 10.1021/bi00189a041 http://dx.doi.org/10.1021/bi00189a041 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.111128198 http://dx.doi.org/10.1073/pnas.111128198 DOI 10.1073/pnas.89.19.9257 http://dx.doi.org/10.1073/pnas.89.19.9257 DOI 10.1074/jbc.M113.525618 http://dx.doi.org/10.1074/jbc.M113.525618 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DisProt DP00349 http://www.disprot.org/protein.php?id=DP00349 EC_number EC:6.3.4.15 {ECO:0000255|HAMAP-Rule:MF_00978} http://www.genome.jp/dbget-bin/www_bget?EC:6.3.4.15 {ECO:0000255|HAMAP-Rule:MF_00978} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L14557 http://www.ebi.ac.uk/ena/data/view/L14557 EMBL M10123 http://www.ebi.ac.uk/ena/data/view/M10123 EMBL M15820 http://www.ebi.ac.uk/ena/data/view/M15820 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 6.3.4.15 {ECO:0000255|HAMAP-Rule:MF_00978} http://enzyme.expasy.org/EC/6.3.4.15 {ECO:0000255|HAMAP-Rule:MF_00978} EchoBASE EB0121 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0121 EcoGene EG10123 http://www.ecogene.org/geneInfo.php?eg_id=EG10123 EnsemblBacteria AAC76951 http://www.ensemblgenomes.org/id/AAC76951 EnsemblBacteria AAC76951 http://www.ensemblgenomes.org/id/AAC76951 EnsemblBacteria BAE77342 http://www.ensemblgenomes.org/id/BAE77342 EnsemblBacteria BAE77342 http://www.ensemblgenomes.org/id/BAE77342 EnsemblBacteria BAE77342 http://www.ensemblgenomes.org/id/BAE77342 EnsemblBacteria b3973 http://www.ensemblgenomes.org/id/b3973 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004077 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004077 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0009102 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009102 GO_process GO:0009305 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009305 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 948469 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948469 HAMAP MF_00978 http://hamap.expasy.org/unirule/MF_00978 HOGENOM HOG000041812 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000041812&db=HOGENOM6 InParanoid P06709 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P06709 IntAct P06709 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P06709* IntEnz 6.3.4.15 {ECO:0000255|HAMAP-Rule:MF_00978} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.4.15 {ECO:0000255|HAMAP-Rule:MF_00978} InterPro IPR003142 http://www.ebi.ac.uk/interpro/entry/IPR003142 InterPro IPR004143 http://www.ebi.ac.uk/interpro/entry/IPR004143 InterPro IPR004408 http://www.ebi.ac.uk/interpro/entry/IPR004408 InterPro IPR004409 http://www.ebi.ac.uk/interpro/entry/IPR004409 InterPro IPR008988 http://www.ebi.ac.uk/interpro/entry/IPR008988 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR013196 http://www.ebi.ac.uk/interpro/entry/IPR013196 InterPro IPR030855 http://www.ebi.ac.uk/interpro/entry/IPR030855 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW3941 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3941 KEGG_Gene eco:b3973 http://www.genome.jp/dbget-bin/www_bget?eco:b3973 KEGG_Orthology KO:K03524 http://www.genome.jp/dbget-bin/www_bget?KO:K03524 KEGG_Pathway ko00780 http://www.genome.jp/kegg-bin/show_pathway?ko00780 KEGG_Reaction rn:R01074 http://www.genome.jp/dbget-bin/www_bget?rn:R01074 KEGG_Reaction rn:R05145 http://www.genome.jp/dbget-bin/www_bget?rn:R05145 MINT MINT-1254106 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1254106 OMA DVCHVVL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DVCHVVL PANTHER PTHR12835 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12835 PDB 1BIA http://www.ebi.ac.uk/pdbe-srv/view/entry/1BIA PDB 1BIB http://www.ebi.ac.uk/pdbe-srv/view/entry/1BIB PDB 1HXD http://www.ebi.ac.uk/pdbe-srv/view/entry/1HXD PDB 1K67 http://www.ebi.ac.uk/pdbe-srv/view/entry/1K67 PDB 2EWN http://www.ebi.ac.uk/pdbe-srv/view/entry/2EWN PDB 4WF2 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF2 PDBsum 1BIA http://www.ebi.ac.uk/pdbsum/1BIA PDBsum 1BIB http://www.ebi.ac.uk/pdbsum/1BIB PDBsum 1HXD http://www.ebi.ac.uk/pdbsum/1HXD PDBsum 1K67 http://www.ebi.ac.uk/pdbsum/1K67 PDBsum 2EWN http://www.ebi.ac.uk/pdbsum/2EWN PDBsum 4WF2 http://www.ebi.ac.uk/pdbsum/4WF2 PROSITE PS51733 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51733 PSORT swissprot:BIRA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BIRA_ECOLI PSORT-B swissprot:BIRA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BIRA_ECOLI PSORT2 swissprot:BIRA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BIRA_ECOLI Pfam PF02237 http://pfam.xfam.org/family/PF02237 Pfam PF03099 http://pfam.xfam.org/family/PF03099 Pfam PF08279 http://pfam.xfam.org/family/PF08279 Phobius swissprot:BIRA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BIRA_ECOLI PhylomeDB P06709 http://phylomedb.org/?seqid=P06709 ProteinModelPortal P06709 http://www.proteinmodelportal.org/query/uniprot/P06709 PubMed 11353844 http://www.ncbi.nlm.nih.gov/pubmed/11353844 PubMed 12527300 http://www.ncbi.nlm.nih.gov/pubmed/12527300 PubMed 1311302 http://www.ncbi.nlm.nih.gov/pubmed/1311302 PubMed 1328157 http://www.ncbi.nlm.nih.gov/pubmed/1328157 PubMed 1409631 http://www.ncbi.nlm.nih.gov/pubmed/1409631 PubMed 16438984 http://www.ncbi.nlm.nih.gov/pubmed/16438984 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 23896299 http://www.ncbi.nlm.nih.gov/pubmed/23896299 PubMed 24189073 http://www.ncbi.nlm.nih.gov/pubmed/24189073 PubMed 2667763 http://www.ncbi.nlm.nih.gov/pubmed/2667763 PubMed 3536662 http://www.ncbi.nlm.nih.gov/pubmed/3536662 PubMed 3899863 http://www.ncbi.nlm.nih.gov/pubmed/3899863 PubMed 6129246 http://www.ncbi.nlm.nih.gov/pubmed/6129246 PubMed 8003500 http://www.ncbi.nlm.nih.gov/pubmed/8003500 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418404 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418404 RefSeq WP_000654630 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000654630 SMR P06709 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P06709 STRING 511145.b3973 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3973&targetmode=cogs STRING COG0340 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0340&targetmode=cogs STRING COG1654 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1654&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SUPFAM SSF50037 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50037 TIGRFAMs TIGR00121 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00121 TIGRFAMs TIGR00122 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00122 UniProtKB BIRA_ECOLI http://www.uniprot.org/uniprot/BIRA_ECOLI UniProtKB-AC P06709 http://www.uniprot.org/uniprot/P06709 charge swissprot:BIRA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BIRA_ECOLI eggNOG COG0340 http://eggnogapi.embl.de/nog_data/html/tree/COG0340 eggNOG COG1654 http://eggnogapi.embl.de/nog_data/html/tree/COG1654 eggNOG ENOG4105HJX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105HJX epestfind swissprot:BIRA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BIRA_ECOLI garnier swissprot:BIRA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BIRA_ECOLI helixturnhelix swissprot:BIRA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BIRA_ECOLI hmoment swissprot:BIRA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BIRA_ECOLI iep swissprot:BIRA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BIRA_ECOLI inforesidue swissprot:BIRA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BIRA_ECOLI octanol swissprot:BIRA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BIRA_ECOLI pepcoil swissprot:BIRA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BIRA_ECOLI pepdigest swissprot:BIRA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BIRA_ECOLI pepinfo swissprot:BIRA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BIRA_ECOLI pepnet swissprot:BIRA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BIRA_ECOLI pepstats swissprot:BIRA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BIRA_ECOLI pepwheel swissprot:BIRA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BIRA_ECOLI pepwindow swissprot:BIRA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BIRA_ECOLI sigcleave swissprot:BIRA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BIRA_ECOLI ## Database ID URL or Descriptions # AltName LIT_ECOLI Bacteriophage T4 late gene expression-blocking protein # AltName LIT_ECOLI GpLit # BioGrid 4263099 10 # EcoGene EG10535 lit # FUNCTION LIT_ECOLI Interacts with a short DNA sequence about one-quarter of the way into the major capsid protein gene 23 of T4; general translation inhibition occurs when this late gene of the virus is expressed. {ECO 0000269|PubMed 2452152}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0008233 peptidase activity; IDA:EcoCyc. # GO_process GO:0006448 regulation of translational elongation; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0008233 peptidase activity # GOslim_process GO:0008150 biological_process # InterPro IPR019504 Peptidase_U49_Lit_pept # Organism LIT_ECOLI Escherichia coli (strain K12) # PATRIC 32117525 VBIEscCol129921_1185 # PIR H64858 BVECLT # Pfam PF10463 Peptidase_U49 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Cell death peptidase {ECO 0000305} # RefSeq NP_415657 NC_000913.3 # RefSeq WP_001257372 NZ_CP010440.1 # SIMILARITY Belongs to the peptidase U49 family. {ECO 0000305}. # SUBCELLULAR LOCATION LIT_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # eggNOG ENOG4106VW7 Bacteria # eggNOG ENOG410YPG7 LUCA BLAST swissprot:LIT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LIT_ECOLI BioCyc ECOL316407:JW1125-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1125-MONOMER BioCyc EcoCyc:EG10535-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10535-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M19634 http://www.ebi.ac.uk/ena/data/view/M19634 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0530 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0530 EcoGene EG10535 http://www.ecogene.org/geneInfo.php?eg_id=EG10535 EnsemblBacteria AAC74223 http://www.ensemblgenomes.org/id/AAC74223 EnsemblBacteria AAC74223 http://www.ensemblgenomes.org/id/AAC74223 EnsemblBacteria BAA35968 http://www.ensemblgenomes.org/id/BAA35968 EnsemblBacteria BAA35968 http://www.ensemblgenomes.org/id/BAA35968 EnsemblBacteria BAA35968 http://www.ensemblgenomes.org/id/BAA35968 EnsemblBacteria b1139 http://www.ensemblgenomes.org/id/b1139 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GO_process GO:0006448 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006448 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 948421 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948421 InterPro IPR019504 http://www.ebi.ac.uk/interpro/entry/IPR019504 KEGG_Gene ecj:JW1125 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1125 KEGG_Gene eco:b1139 http://www.genome.jp/dbget-bin/www_bget?eco:b1139 OMA IWHEIAH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IWHEIAH PSORT swissprot:LIT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LIT_ECOLI PSORT-B swissprot:LIT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LIT_ECOLI PSORT2 swissprot:LIT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LIT_ECOLI Pfam PF10463 http://pfam.xfam.org/family/PF10463 Phobius swissprot:LIT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LIT_ECOLI ProteinModelPortal P11072 http://www.proteinmodelportal.org/query/uniprot/P11072 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2452152 http://www.ncbi.nlm.nih.gov/pubmed/2452152 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415657 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415657 RefSeq WP_001257372 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001257372 STRING 511145.b1139 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1139&targetmode=cogs UniProtKB LIT_ECOLI http://www.uniprot.org/uniprot/LIT_ECOLI UniProtKB-AC P11072 http://www.uniprot.org/uniprot/P11072 charge swissprot:LIT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LIT_ECOLI eggNOG ENOG4106VW7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106VW7 eggNOG ENOG410YPG7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YPG7 epestfind swissprot:LIT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LIT_ECOLI garnier swissprot:LIT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LIT_ECOLI helixturnhelix swissprot:LIT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LIT_ECOLI hmoment swissprot:LIT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LIT_ECOLI iep swissprot:LIT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LIT_ECOLI inforesidue swissprot:LIT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LIT_ECOLI octanol swissprot:LIT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LIT_ECOLI pepcoil swissprot:LIT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LIT_ECOLI pepdigest swissprot:LIT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LIT_ECOLI pepinfo swissprot:LIT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LIT_ECOLI pepnet swissprot:LIT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LIT_ECOLI pepstats swissprot:LIT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LIT_ECOLI pepwheel swissprot:LIT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LIT_ECOLI pepwindow swissprot:LIT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LIT_ECOLI sigcleave swissprot:LIT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LIT_ECOLI ## Database ID URL or Descriptions # AltName ALKH_ECOLI 2-keto-3-deoxy-6-phosphogluconate aldolase # AltName ALKH_ECOLI 2-keto-4-hydroxyglutarate aldolase # AltName ALKH_ECOLI Phospho-2-dehydro-3-deoxygluconate aldolase # AltName ALKH_ECOLI Phospho-2-keto-3-deoxygluconate aldolase # BIOPHYSICOCHEMICAL PROPERTIES ALKH_ECOLI Kinetic parameters KM=0.1 mM for KDPG {ECO 0000269|PubMed 11342129, ECO 0000269|PubMed 17981470}; KM=9 mM for 2-oxobutyrate {ECO 0000269|PubMed 11342129, ECO 0000269|PubMed 17981470}; KM=10 mM for pyruvate {ECO 0000269|PubMed 11342129, ECO 0000269|PubMed 17981470}; Note=Kcat is 80 sec(-1) for KDPG, 0.012 sec(-1) for pyruvate and 0.0004 sec(-1) for 2-oxobutyrate.; # BRENDA 4.1.2.14 2026 # BRENDA 4.1.3.42 2026 # BioGrid 4259153 13 # CATALYTIC ACTIVITY 2-dehydro-3-deoxy-6-phosphate-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate. {ECO:0000269|PubMed 17981470}. # CATALYTIC ACTIVITY 4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate. {ECO:0000269|PubMed 17981470}. # CDD cd00452 KDPG_aldolase # DISRUPTION PHENOTYPE Cells lacking this gene lose KHG aldolase activity. {ECO:0000269|PubMed 1339418}. # EcoGene EG10256 eda # FUNCTION ALKH_ECOLI Involved in the degradation of glucose via the Entner- Doudoroff pathway. Catalyzes the reversible, stereospecific retro- aldol cleavage of 2-Keto-3-deoxy-6-phosphogluconate (KDPG) to pyruvate and D-glyceraldehyde-3-phosphate. In the synthetic direction, it catalyzes the addition of pyruvate to electrophilic aldehydes with si-facial selectivity. It accepts some nucleophiles other than pyruvate, including 2-oxobutanoate, phenylpyruvate, and fluorobutanoate. It has a preference for the S-configuration at C2 of the electrophile. {ECO 0000269|PubMed 1339418, ECO 0000269|PubMed 17981470}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0008675 2-dehydro-3-deoxy-phosphogluconate aldolase activity; IMP:EcoliWiki. # GO_function GO:0008700 4-hydroxy-2-oxoglutarate aldolase activity; IDA:UniProtKB. # GO_process GO:0008152 metabolic process; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0008150 biological_process # Gene3D 3.20.20.70 -; 1. # INDUCTION Constitutive, three-fold induction occurs for growth on gluconate and two-fold for growth on hexuronic acids. {ECO:0000269|PubMed 17981470}. # INTERACTION ALKH_ECOLI Self; NbExp=3; IntAct=EBI-558114, EBI-558114; # IntAct P0A955 9 # InterPro IPR000887 Aldlse_KDPG_KHG # InterPro IPR013785 Aldolase_TIM # InterPro IPR031337 KDPG/KHG_AS_1 # InterPro IPR031338 KDPG/KHG_AS_2 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00030 Pentose phosphate pathway # KEGG_Pathway ko00040 Pentose and glucuronate interconversions # KEGG_Pathway ko00330 Arginine and proline metabolism # KEGG_Pathway ko00630 Glyoxylate and dicarboxylate metabolism # Organism ALKH_ECOLI Escherichia coli (strain K12) # PATHWAY ALKH_ECOLI Carbohydrate metabolism; glyoxylate and dicarboxylate metabolism. # PATHWAY Carbohydrate acid metabolism; 2-dehydro-3-deoxy-D- gluconate degradation; D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-gluconate step 2/2. # PATRIC 32119021 VBIEscCol129921_1928 # PDB 1EUA X-ray; 1.95 A; A/B/C=1-213 # PDB 1EUN X-ray; 2.00 A; A/B/C=1-213 # PDB 1FQ0 X-ray; 2.10 A; A/B/C=1-213 # PDB 1FWR X-ray; 2.70 A; A/B/C=1-213 # PDB 1WAU X-ray; 2.80 A; A=1-213 # PDB 1WBH X-ray; 1.55 A; A/B/C=1-213 # PDB 2C0A X-ray; 1.55 A; A/B/C=1-213 # PIR B42986 ADECOG # PROSITE PS00159 ALDOLASE_KDPG_KHG_1 # PROSITE PS00160 ALDOLASE_KDPG_KHG_2 # Pfam PF01081 Aldolase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ALKH_ECOLI 2-dehydro-3-deoxy-phosphogluconate aldolase # RecName ALKH_ECOLI 4-hydroxy-2-oxoglutarate aldolase # RecName ALKH_ECOLI KHG/KDPG aldolase # RecName ALKH_ECOLI KHG/KDPG aldolase # RefSeq NP_416364 NC_000913.3 # RefSeq WP_000800512 NZ_LN832404.1 # SIMILARITY Belongs to the KHG/KDPG aldolase family. {ECO 0000305}. # SUBCELLULAR LOCATION ALKH_ECOLI Cytoplasm {ECO 0000250}. # SUBUNIT ALKH_ECOLI Homotrimer. {ECO 0000269|PubMed 11274385, ECO 0000269|PubMed 11342129, ECO 0000269|PubMed 16403639}. # TIGRFAMs TIGR01182 eda # UniPathway UPA00856 UER00829 # eggNOG COG0800 LUCA # eggNOG ENOG4108UHU Bacteria BLAST swissprot:ALKH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ALKH_ECOLI BioCyc ECOL316407:JW1839-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1839-MONOMER BioCyc EcoCyc:KDPGALDOL-4OH2OXOGLUTARALDOL-MONOMER http://biocyc.org/getid?id=EcoCyc:KDPGALDOL-4OH2OXOGLUTARALDOL-MONOMER BioCyc MetaCyc:KDPGALDOL-4OH2OXOGLUTARALDOL-MONOMER http://biocyc.org/getid?id=MetaCyc:KDPGALDOL-4OH2OXOGLUTARALDOL-MONOMER COG COG0800 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0800 DIP DIP-36196N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36196N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0378-1119(93)90362-7 http://dx.doi.org/10.1016/0378-1119(93)90362-7 DOI 10.1016/S0969-2126(00)00555-4 http://dx.doi.org/10.1016/S0969-2126(00)00555-4 DOI 10.1016/j.bmc.2005.12.022 http://dx.doi.org/10.1016/j.bmc.2005.12.022 DOI 10.1016/j.bmc.2007.10.043 http://dx.doi.org/10.1016/j.bmc.2007.10.043 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.071380898 http://dx.doi.org/10.1073/pnas.071380898 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.1.2.14 http://www.genome.jp/dbget-bin/www_bget?EC:4.1.2.14 EC_number EC:4.1.3.16 http://www.genome.jp/dbget-bin/www_bget?EC:4.1.3.16 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L20897 http://www.ebi.ac.uk/ena/data/view/L20897 EMBL M87458 http://www.ebi.ac.uk/ena/data/view/M87458 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X63694 http://www.ebi.ac.uk/ena/data/view/X63694 EMBL X68871 http://www.ebi.ac.uk/ena/data/view/X68871 ENZYME 4.1.2.14 http://enzyme.expasy.org/EC/4.1.2.14 ENZYME 4.1.3.16 http://enzyme.expasy.org/EC/4.1.3.16 EchoBASE EB0252 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0252 EcoGene EG10256 http://www.ecogene.org/geneInfo.php?eg_id=EG10256 EnsemblBacteria AAC74920 http://www.ensemblgenomes.org/id/AAC74920 EnsemblBacteria AAC74920 http://www.ensemblgenomes.org/id/AAC74920 EnsemblBacteria BAA15658 http://www.ensemblgenomes.org/id/BAA15658 EnsemblBacteria BAA15658 http://www.ensemblgenomes.org/id/BAA15658 EnsemblBacteria BAA15658 http://www.ensemblgenomes.org/id/BAA15658 EnsemblBacteria b1850 http://www.ensemblgenomes.org/id/b1850 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0008675 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008675 GO_function GO:0008700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008700 GO_process GO:0008152 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008152 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 946367 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946367 HOGENOM HOG000233114 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000233114&db=HOGENOM6 InParanoid P0A955 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A955 IntAct P0A955 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A955* IntEnz 4.1.2.14 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.2.14 IntEnz 4.1.3.16 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.3.16 InterPro IPR000887 http://www.ebi.ac.uk/interpro/entry/IPR000887 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR031337 http://www.ebi.ac.uk/interpro/entry/IPR031337 InterPro IPR031338 http://www.ebi.ac.uk/interpro/entry/IPR031338 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1839 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1839 KEGG_Gene eco:b1850 http://www.genome.jp/dbget-bin/www_bget?eco:b1850 KEGG_Orthology KO:K01625 http://www.genome.jp/dbget-bin/www_bget?KO:K01625 KEGG_Pathway ko00030 http://www.genome.jp/kegg-bin/show_pathway?ko00030 KEGG_Pathway ko00040 http://www.genome.jp/kegg-bin/show_pathway?ko00040 KEGG_Pathway ko00330 http://www.genome.jp/kegg-bin/show_pathway?ko00330 KEGG_Pathway ko00630 http://www.genome.jp/kegg-bin/show_pathway?ko00630 KEGG_Reaction rn:R00470 http://www.genome.jp/dbget-bin/www_bget?rn:R00470 KEGG_Reaction rn:R00471 http://www.genome.jp/dbget-bin/www_bget?rn:R00471 KEGG_Reaction rn:R05605 http://www.genome.jp/dbget-bin/www_bget?rn:R05605 OMA FLISPGL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FLISPGL PDB 1EUA http://www.ebi.ac.uk/pdbe-srv/view/entry/1EUA PDB 1EUN http://www.ebi.ac.uk/pdbe-srv/view/entry/1EUN PDB 1FQ0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1FQ0 PDB 1FWR http://www.ebi.ac.uk/pdbe-srv/view/entry/1FWR PDB 1WAU http://www.ebi.ac.uk/pdbe-srv/view/entry/1WAU PDB 1WBH http://www.ebi.ac.uk/pdbe-srv/view/entry/1WBH PDB 2C0A http://www.ebi.ac.uk/pdbe-srv/view/entry/2C0A PDBsum 1EUA http://www.ebi.ac.uk/pdbsum/1EUA PDBsum 1EUN http://www.ebi.ac.uk/pdbsum/1EUN PDBsum 1FQ0 http://www.ebi.ac.uk/pdbsum/1FQ0 PDBsum 1FWR http://www.ebi.ac.uk/pdbsum/1FWR PDBsum 1WAU http://www.ebi.ac.uk/pdbsum/1WAU PDBsum 1WBH http://www.ebi.ac.uk/pdbsum/1WBH PDBsum 2C0A http://www.ebi.ac.uk/pdbsum/2C0A PROSITE PS00159 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00159 PROSITE PS00160 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00160 PSORT swissprot:ALKH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ALKH_ECOLI PSORT-B swissprot:ALKH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ALKH_ECOLI PSORT2 swissprot:ALKH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ALKH_ECOLI Pfam PF01081 http://pfam.xfam.org/family/PF01081 Phobius swissprot:ALKH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ALKH_ECOLI PhylomeDB P0A955 http://phylomedb.org/?seqid=P0A955 ProteinModelPortal P0A955 http://www.proteinmodelportal.org/query/uniprot/P0A955 PubMed 11274385 http://www.ncbi.nlm.nih.gov/pubmed/11274385 PubMed 11342129 http://www.ncbi.nlm.nih.gov/pubmed/11342129 PubMed 1339418 http://www.ncbi.nlm.nih.gov/pubmed/1339418 PubMed 1624451 http://www.ncbi.nlm.nih.gov/pubmed/1624451 PubMed 16403639 http://www.ncbi.nlm.nih.gov/pubmed/16403639 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17981470 http://www.ncbi.nlm.nih.gov/pubmed/17981470 PubMed 1978721 http://www.ncbi.nlm.nih.gov/pubmed/1978721 PubMed 3136164 http://www.ncbi.nlm.nih.gov/pubmed/3136164 PubMed 8344525 http://www.ncbi.nlm.nih.gov/pubmed/8344525 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_416364 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416364 RefSeq WP_000800512 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000800512 SMR P0A955 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A955 STRING 511145.b1850 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1850&targetmode=cogs STRING COG0800 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0800&targetmode=cogs SWISS-2DPAGE P0A955 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A955 TIGRFAMs TIGR01182 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01182 UniProtKB ALKH_ECOLI http://www.uniprot.org/uniprot/ALKH_ECOLI UniProtKB-AC P0A955 http://www.uniprot.org/uniprot/P0A955 charge swissprot:ALKH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ALKH_ECOLI eggNOG COG0800 http://eggnogapi.embl.de/nog_data/html/tree/COG0800 eggNOG ENOG4108UHU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UHU epestfind swissprot:ALKH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ALKH_ECOLI garnier swissprot:ALKH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ALKH_ECOLI helixturnhelix swissprot:ALKH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ALKH_ECOLI hmoment swissprot:ALKH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ALKH_ECOLI iep swissprot:ALKH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ALKH_ECOLI inforesidue swissprot:ALKH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ALKH_ECOLI octanol swissprot:ALKH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ALKH_ECOLI pepcoil swissprot:ALKH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ALKH_ECOLI pepdigest swissprot:ALKH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ALKH_ECOLI pepinfo swissprot:ALKH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ALKH_ECOLI pepnet swissprot:ALKH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ALKH_ECOLI pepstats swissprot:ALKH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ALKH_ECOLI pepwheel swissprot:ALKH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ALKH_ECOLI pepwindow swissprot:ALKH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ALKH_ECOLI sigcleave swissprot:ALKH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ALKH_ECOLI ## Database ID URL or Descriptions # BioGrid 4261507 104 # CATALYTIC ACTIVITY HRPA_ECOLI ATP + H(2)O = ADP + phosphate. # EcoGene EG12936 hrpA # FUNCTION HRPA_ECOLI Not yet known. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0004004 ATP-dependent RNA helicase activity; ISS:EcoCyc. # GO_function GO:0004386 helicase activity; IMP:EcoliWiki. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0044822 poly(A) RNA binding; IBA:GO_Central. # GO_process GO:0006397 mRNA processing; IMP:EcoCyc. # GO_process GO:0009451 RNA modification; IMP:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0004386 helicase activity # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006397 mRNA processing # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.50.300 -; 2. # IntAct P43329 26 # InterPro IPR001650 Helicase_C # InterPro IPR003593 AAA+_ATPase # InterPro IPR007502 Helicase-assoc_dom # InterPro IPR010222 RNA_helicase_HrpA # InterPro IPR011545 DEAD/DEAH_box_helicase_dom # InterPro IPR011709 DUF1605 # InterPro IPR014001 Helicase_ATP-bd # InterPro IPR024590 HrpA_C # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko01000 Enzymes # Organism HRPA_ECOLI Escherichia coli (strain K12) # PATRIC 32118112 VBIEscCol129921_1476 # PIR H64892 H64892 # PROSITE PS51192 HELICASE_ATP_BIND_1 # PROSITE PS51194 HELICASE_CTER # Pfam PF00270 DEAD # Pfam PF00271 Helicase_C # Pfam PF04408 HA2 # Pfam PF07717 OB_NTP_bind # Pfam PF11898 DUF3418 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HRPA_ECOLI ATP-dependent RNA helicase HrpA # RefSeq NP_415931 NC_000913.3 # RefSeq WP_000139543 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA07685.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA15029.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the DEAD box helicase family. DEAH subfamily. {ECO 0000305}. # SIMILARITY Contains 1 helicase ATP-binding domain. {ECO:0000255|PROSITE-ProRule PRU00541}. # SIMILARITY Contains 1 helicase C-terminal domain. {ECO:0000255|PROSITE-ProRule PRU00542}. # SMART SM00382 AAA # SMART SM00487 DEXDc # SMART SM00490 HELICc # SMART SM00847 HA2 # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR01967 DEAH_box_HrpA # eggNOG COG1643 LUCA # eggNOG ENOG4105CQ7 Bacteria BLAST swissprot:HRPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HRPA_ECOLI BioCyc ECOL316407:JW5905-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5905-MONOMER BioCyc EcoCyc:G6732-MONOMER http://biocyc.org/getid?id=EcoCyc:G6732-MONOMER COG COG1643 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1643 DIP DIP-9937N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9937N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/23.4.595 http://dx.doi.org/10.1093/nar/23.4.595 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.4.13 http://www.genome.jp/dbget-bin/www_bget?EC:3.6.4.13 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D42105 http://www.ebi.ac.uk/ena/data/view/D42105 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.6.4.13 http://enzyme.expasy.org/EC/3.6.4.13 EchoBASE EB2772 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2772 EcoGene EG12936 http://www.ecogene.org/geneInfo.php?eg_id=EG12936 EnsemblBacteria AAC74495 http://www.ensemblgenomes.org/id/AAC74495 EnsemblBacteria AAC74495 http://www.ensemblgenomes.org/id/AAC74495 EnsemblBacteria BAA15029 http://www.ensemblgenomes.org/id/BAA15029 EnsemblBacteria BAA15029 http://www.ensemblgenomes.org/id/BAA15029 EnsemblBacteria BAA15029 http://www.ensemblgenomes.org/id/BAA15029 EnsemblBacteria b1413 http://www.ensemblgenomes.org/id/b1413 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004004 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004004 GO_function GO:0004386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004386 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0044822 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044822 GO_process GO:0006397 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006397 GO_process GO:0009451 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009451 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0004386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004386 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006397 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006397 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948444 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948444 HOGENOM HOG000247272 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000247272&db=HOGENOM6 InParanoid P43329 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P43329 IntAct P43329 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P43329* IntEnz 3.6.4.13 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.4.13 InterPro IPR001650 http://www.ebi.ac.uk/interpro/entry/IPR001650 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR007502 http://www.ebi.ac.uk/interpro/entry/IPR007502 InterPro IPR010222 http://www.ebi.ac.uk/interpro/entry/IPR010222 InterPro IPR011545 http://www.ebi.ac.uk/interpro/entry/IPR011545 InterPro IPR011709 http://www.ebi.ac.uk/interpro/entry/IPR011709 InterPro IPR014001 http://www.ebi.ac.uk/interpro/entry/IPR014001 InterPro IPR024590 http://www.ebi.ac.uk/interpro/entry/IPR024590 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5905 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5905 KEGG_Gene eco:b1413 http://www.genome.jp/dbget-bin/www_bget?eco:b1413 KEGG_Orthology KO:K03578 http://www.genome.jp/dbget-bin/www_bget?KO:K03578 MINT MINT-1229564 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1229564 OMA YIKLMTD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YIKLMTD PROSITE PS51192 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51192 PROSITE PS51194 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51194 PSORT swissprot:HRPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HRPA_ECOLI PSORT-B swissprot:HRPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HRPA_ECOLI PSORT2 swissprot:HRPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HRPA_ECOLI Pfam PF00270 http://pfam.xfam.org/family/PF00270 Pfam PF00271 http://pfam.xfam.org/family/PF00271 Pfam PF04408 http://pfam.xfam.org/family/PF04408 Pfam PF07717 http://pfam.xfam.org/family/PF07717 Pfam PF11898 http://pfam.xfam.org/family/PF11898 Phobius swissprot:HRPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HRPA_ECOLI PhylomeDB P43329 http://phylomedb.org/?seqid=P43329 ProteinModelPortal P43329 http://www.proteinmodelportal.org/query/uniprot/P43329 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7899078 http://www.ncbi.nlm.nih.gov/pubmed/7899078 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415931 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415931 RefSeq WP_000139543 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000139543 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMART SM00487 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00487 SMART SM00490 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00490 SMART SM00847 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00847 SMR P43329 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P43329 STRING 511145.b1413 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1413&targetmode=cogs STRING COG1643 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1643&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR01967 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01967 UniProtKB HRPA_ECOLI http://www.uniprot.org/uniprot/HRPA_ECOLI UniProtKB-AC P43329 http://www.uniprot.org/uniprot/P43329 charge swissprot:HRPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HRPA_ECOLI eggNOG COG1643 http://eggnogapi.embl.de/nog_data/html/tree/COG1643 eggNOG ENOG4105CQ7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CQ7 epestfind swissprot:HRPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HRPA_ECOLI garnier swissprot:HRPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HRPA_ECOLI helixturnhelix swissprot:HRPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HRPA_ECOLI hmoment swissprot:HRPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HRPA_ECOLI iep swissprot:HRPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HRPA_ECOLI inforesidue swissprot:HRPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HRPA_ECOLI octanol swissprot:HRPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HRPA_ECOLI pepcoil swissprot:HRPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HRPA_ECOLI pepdigest swissprot:HRPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HRPA_ECOLI pepinfo swissprot:HRPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HRPA_ECOLI pepnet swissprot:HRPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HRPA_ECOLI pepstats swissprot:HRPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HRPA_ECOLI pepwheel swissprot:HRPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HRPA_ECOLI pepwindow swissprot:HRPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HRPA_ECOLI sigcleave swissprot:HRPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HRPA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260623 61 # EcoGene EG13197 yfjK # GO_process GO:0010212 response to ionizing radiation; IMP:EcoCyc. # GO_process GO:0051607 defense response to virus; IMP:EcoCyc. # GOslim_process GO:0002376 immune system process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0044403 symbiosis, encompassing mutualism through parasitism # Gene3D 3.40.50.300 -; 2. # IntAct P52126 23 # InterPro IPR001650 Helicase_C # InterPro IPR014001 Helicase_ATP-bd # InterPro IPR027417 P-loop_NTPase # Organism YFJK_ECOLI Escherichia coli (strain K12) # PATRIC 32120647 VBIEscCol129921_2722 # PIR T08639 T08639 # PROSITE PS51192 HELICASE_ATP_BIND_1 # PROSITE PS51194 HELICASE_CTER # Pfam PF00271 Helicase_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFJK_ECOLI Uncharacterized protein YfjK # RefSeq NP_417116 NC_000913.3 # RefSeq WP_000136402 NZ_LN832404.1 # SIMILARITY Contains 1 helicase ATP-binding domain. {ECO:0000255|PROSITE-ProRule PRU00541}. # SIMILARITY Contains 1 helicase C-terminal domain. {ECO:0000255|PROSITE-ProRule PRU00542}. # SMART SM00487 DEXDc # SMART SM00490 HELICc # SUPFAM SSF52540 SSF52540; 2 # eggNOG COG1204 LUCA # eggNOG ENOG4107UNZ Bacteria BLAST swissprot:YFJK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFJK_ECOLI BioCyc ECOL316407:JW2608-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2608-MONOMER BioCyc EcoCyc:G7362-MONOMER http://biocyc.org/getid?id=EcoCyc:G7362-MONOMER DIP DIP-12076N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12076N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36840 http://www.ebi.ac.uk/ena/data/view/U36840 EchoBASE EB2989 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2989 EcoGene EG13197 http://www.ecogene.org/geneInfo.php?eg_id=EG13197 EnsemblBacteria AAC75675 http://www.ensemblgenomes.org/id/AAC75675 EnsemblBacteria AAC75675 http://www.ensemblgenomes.org/id/AAC75675 EnsemblBacteria BAE76762 http://www.ensemblgenomes.org/id/BAE76762 EnsemblBacteria BAE76762 http://www.ensemblgenomes.org/id/BAE76762 EnsemblBacteria BAE76762 http://www.ensemblgenomes.org/id/BAE76762 EnsemblBacteria b2627 http://www.ensemblgenomes.org/id/b2627 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0010212 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010212 GO_process GO:0051607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051607 GOslim_process GO:0002376 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0044403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947111 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947111 HOGENOM HOG000036311 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000036311&db=HOGENOM6 InParanoid P52126 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P52126 IntAct P52126 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P52126* InterPro IPR001650 http://www.ebi.ac.uk/interpro/entry/IPR001650 InterPro IPR014001 http://www.ebi.ac.uk/interpro/entry/IPR014001 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Gene ecj:JW2608 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2608 KEGG_Gene eco:b2627 http://www.genome.jp/dbget-bin/www_bget?eco:b2627 MINT MINT-1230544 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1230544 OMA TSTMIEG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TSTMIEG PROSITE PS51192 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51192 PROSITE PS51194 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51194 PSORT swissprot:YFJK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFJK_ECOLI PSORT-B swissprot:YFJK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFJK_ECOLI PSORT2 swissprot:YFJK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFJK_ECOLI Pfam PF00271 http://pfam.xfam.org/family/PF00271 Phobius swissprot:YFJK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFJK_ECOLI ProteinModelPortal P52126 http://www.proteinmodelportal.org/query/uniprot/P52126 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417116 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417116 RefSeq WP_000136402 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000136402 SMART SM00487 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00487 SMART SM00490 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00490 SMR P52126 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P52126 STRING 511145.b2627 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2627&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB YFJK_ECOLI http://www.uniprot.org/uniprot/YFJK_ECOLI UniProtKB-AC P52126 http://www.uniprot.org/uniprot/P52126 charge swissprot:YFJK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFJK_ECOLI eggNOG COG1204 http://eggnogapi.embl.de/nog_data/html/tree/COG1204 eggNOG ENOG4107UNZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107UNZ epestfind swissprot:YFJK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFJK_ECOLI garnier swissprot:YFJK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFJK_ECOLI helixturnhelix swissprot:YFJK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFJK_ECOLI hmoment swissprot:YFJK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFJK_ECOLI iep swissprot:YFJK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFJK_ECOLI inforesidue swissprot:YFJK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFJK_ECOLI octanol swissprot:YFJK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFJK_ECOLI pepcoil swissprot:YFJK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFJK_ECOLI pepdigest swissprot:YFJK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFJK_ECOLI pepinfo swissprot:YFJK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFJK_ECOLI pepnet swissprot:YFJK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFJK_ECOLI pepstats swissprot:YFJK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFJK_ECOLI pepwheel swissprot:YFJK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFJK_ECOLI pepwindow swissprot:YFJK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFJK_ECOLI sigcleave swissprot:YFJK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFJK_ECOLI ## Database ID URL or Descriptions # BioGrid 4260745 11 # EcoGene EG13130 ygcW # GO_function GO:0016491 oxidoreductase activity; IEA:UniProtKB-KW. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006950 response to stress # Gene3D 3.40.50.720 -; 1. # InterPro IPR002347 SDR_fam # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR020904 Sc_DH/Rdtase_CS # Organism YGCW_ECOLI Escherichia coli (strain K12) # PANTHER PTHR24322 PTHR24322; 2 # PATRIC 32120958 VBIEscCol129921_2871 # PIR B65059 B65059 # PRINTS PR00080 SDRFAMILY # PRINTS PR00081 GDHRDH # PROSITE PS00061 ADH_SHORT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGCW_ECOLI Uncharacterized oxidoreductase YgcW # RefSeq NP_417254 NC_000913.3 # RefSeq WP_000021334 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA69285.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO 0000305}. # SUPFAM SSF51735 SSF51735 # eggNOG ENOG4105CHR Bacteria # eggNOG ENOG410XNW1 LUCA BLAST swissprot:YGCW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGCW_ECOLI BioCyc ECOL316407:JW5443-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5443-MONOMER BioCyc EcoCyc:G7440-MONOMER http://biocyc.org/getid?id=EcoCyc:G7440-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- EchoBASE EB2930 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2930 EcoGene EG13130 http://www.ecogene.org/geneInfo.php?eg_id=EG13130 EnsemblBacteria AAC75816 http://www.ensemblgenomes.org/id/AAC75816 EnsemblBacteria AAC75816 http://www.ensemblgenomes.org/id/AAC75816 EnsemblBacteria BAA16569 http://www.ensemblgenomes.org/id/BAA16569 EnsemblBacteria BAA16569 http://www.ensemblgenomes.org/id/BAA16569 EnsemblBacteria BAA16569 http://www.ensemblgenomes.org/id/BAA16569 EnsemblBacteria b2774 http://www.ensemblgenomes.org/id/b2774 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 947232 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947232 InParanoid P76633 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76633 IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR002347 http://www.ebi.ac.uk/interpro/entry/IPR002347 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR020904 http://www.ebi.ac.uk/interpro/entry/IPR020904 KEGG_Gene ecj:JW5443 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5443 KEGG_Gene eco:b2774 http://www.genome.jp/dbget-bin/www_bget?eco:b2774 MINT MINT-1246789 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1246789 OMA LAHYEIR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LAHYEIR PANTHER PTHR24322 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24322 PRINTS PR00080 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00080 PRINTS PR00081 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00081 PROSITE PS00061 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00061 PSORT swissprot:YGCW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGCW_ECOLI PSORT-B swissprot:YGCW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGCW_ECOLI PSORT2 swissprot:YGCW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGCW_ECOLI Phobius swissprot:YGCW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGCW_ECOLI PhylomeDB P76633 http://phylomedb.org/?seqid=P76633 ProteinModelPortal P76633 http://www.proteinmodelportal.org/query/uniprot/P76633 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417254 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417254 RefSeq WP_000021334 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000021334 SMR P76633 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76633 STRING 511145.b2774 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2774&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB YGCW_ECOLI http://www.uniprot.org/uniprot/YGCW_ECOLI UniProtKB-AC P76633 http://www.uniprot.org/uniprot/P76633 charge swissprot:YGCW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGCW_ECOLI eggNOG ENOG4105CHR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CHR eggNOG ENOG410XNW1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNW1 epestfind swissprot:YGCW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGCW_ECOLI garnier swissprot:YGCW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGCW_ECOLI helixturnhelix swissprot:YGCW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGCW_ECOLI hmoment swissprot:YGCW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGCW_ECOLI iep swissprot:YGCW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGCW_ECOLI inforesidue swissprot:YGCW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGCW_ECOLI octanol swissprot:YGCW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGCW_ECOLI pepcoil swissprot:YGCW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGCW_ECOLI pepdigest swissprot:YGCW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGCW_ECOLI pepinfo swissprot:YGCW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGCW_ECOLI pepnet swissprot:YGCW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGCW_ECOLI pepstats swissprot:YGCW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGCW_ECOLI pepwheel swissprot:YGCW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGCW_ECOLI pepwindow swissprot:YGCW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGCW_ECOLI sigcleave swissprot:YGCW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGCW_ECOLI ## Database ID URL or Descriptions # BioGrid 4263066 14 # COFACTOR LOIP_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000305}; Note=Binds 1 zinc ion per subunit. {ECO 0000305}; # EcoGene EG11291 loiP # FUNCTION LOIP_ECOLI Metalloprotease that cleaves substrates preferentially between Phe-Phe residues. Plays a role in response to some stress conditions. Seems to regulate the expression of speB. {ECO 0000269|PubMed 1310091, ECO 0000269|PubMed 17651431, ECO 0000269|PubMed 17909889, ECO 0000269|PubMed 22491786}. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_function GO:0004222 metalloendopeptidase activity; IEA:InterPro. # GO_function GO:0008237 metallopeptidase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0043167 ion binding # INDUCTION LOIP_ECOLI Induced by heat shock and low osmolarity. {ECO 0000269|PubMed 17651431, ECO 0000269|PubMed 17909889, ECO 0000269|PubMed 22491786}. # IntAct P25894 3 # InterPro IPR001915 Peptidase_M48 # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # Organism LOIP_ECOLI Escherichia coli (strain K12) # PATRIC 32121284 VBIEscCol129921_3030 # PIR G65078 G65078 # PROSITE PS51257 PROKAR_LIPOPROTEIN # PTM LOIP_ECOLI The intramolecular disulfide bond improves the stability and the activity of LoiP. It forms even in the absence of the oxido- reductase DsbA (PubMed 22491786). {ECO 0000269|PubMed 22491786}. # Pfam PF01435 Peptidase_M48 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LOIP_ECOLI Metalloprotease LoiP # RefSeq NP_417411 NC_000913.3 # RefSeq WP_001326497 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA69103.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAA83911.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the peptidase M48B family. {ECO 0000305}. # SUBCELLULAR LOCATION LOIP_ECOLI Cell outer membrane {ECO 0000269|PubMed 17909889, ECO 0000269|PubMed 22491786}; Lipid- anchor {ECO 0000255|PROSITE-ProRule PRU00303, ECO 0000269|PubMed 17909889, ECO 0000269|PubMed 22491786}. Note=Proper membrane localization can depend on BepA. # SUBUNIT LOIP_ECOLI Interacts with Era and BepA. {ECO 0000269|PubMed 17651431, ECO 0000269|PubMed 22491786}. # eggNOG COG0501 LUCA # eggNOG ENOG4108K0D Bacteria BLAST swissprot:LOIP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LOIP_ECOLI BioCyc ECOL316407:JW2903-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2903-MONOMER BioCyc EcoCyc:EG11291-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11291-MONOMER BioCyc MetaCyc:EG11291-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11291-MONOMER COG COG0501 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0501 DIP DIP-12186N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12186N DOI 10.1007/s00284-007-9030-7 http://dx.doi.org/10.1007/s00284-007-9030-7 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1039/c2mb05506f http://dx.doi.org/10.1039/c2mb05506f DOI 10.1111/j.1574-6968.2007.00860.x http://dx.doi.org/10.1111/j.1574-6968.2007.00860.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.24.- http://www.genome.jp/dbget-bin/www_bget?EC:3.4.24.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M32363 http://www.ebi.ac.uk/ena/data/view/M32363 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 ENZYME 3.4.24.- http://enzyme.expasy.org/EC/3.4.24.- EchoBASE EB1268 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1268 EcoGene EG11291 http://www.ecogene.org/geneInfo.php?eg_id=EG11291 EnsemblBacteria AAC75973 http://www.ensemblgenomes.org/id/AAC75973 EnsemblBacteria AAC75973 http://www.ensemblgenomes.org/id/AAC75973 EnsemblBacteria BAE76999 http://www.ensemblgenomes.org/id/BAE76999 EnsemblBacteria BAE76999 http://www.ensemblgenomes.org/id/BAE76999 EnsemblBacteria BAE76999 http://www.ensemblgenomes.org/id/BAE76999 EnsemblBacteria b2936 http://www.ensemblgenomes.org/id/b2936 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_function GO:0004222 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004222 GO_function GO:0008237 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008237 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GeneID 945173 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945173 HOGENOM HOG000264551 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000264551&db=HOGENOM6 InParanoid P25894 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P25894 IntAct P25894 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P25894* IntEnz 3.4.24 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.24 InterPro IPR001915 http://www.ebi.ac.uk/interpro/entry/IPR001915 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW2903 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2903 KEGG_Gene eco:b2936 http://www.genome.jp/dbget-bin/www_bget?eco:b2936 KEGG_Orthology KO:K07387 http://www.genome.jp/dbget-bin/www_bget?KO:K07387 MINT MINT-1288575 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1288575 OMA MFDSHPG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MFDSHPG PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:LOIP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LOIP_ECOLI PSORT-B swissprot:LOIP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LOIP_ECOLI PSORT2 swissprot:LOIP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LOIP_ECOLI Pfam PF01435 http://pfam.xfam.org/family/PF01435 Phobius swissprot:LOIP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LOIP_ECOLI PhylomeDB P25894 http://phylomedb.org/?seqid=P25894 ProteinModelPortal P25894 http://www.proteinmodelportal.org/query/uniprot/P25894 PubMed 1310091 http://www.ncbi.nlm.nih.gov/pubmed/1310091 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17651431 http://www.ncbi.nlm.nih.gov/pubmed/17651431 PubMed 17909889 http://www.ncbi.nlm.nih.gov/pubmed/17909889 PubMed 2153656 http://www.ncbi.nlm.nih.gov/pubmed/2153656 PubMed 22491786 http://www.ncbi.nlm.nih.gov/pubmed/22491786 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417411 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417411 RefSeq WP_001326497 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001326497 SMR P25894 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P25894 STRING 511145.b2936 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2936&targetmode=cogs STRING COG0501 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0501&targetmode=cogs UniProtKB LOIP_ECOLI http://www.uniprot.org/uniprot/LOIP_ECOLI UniProtKB-AC P25894 http://www.uniprot.org/uniprot/P25894 charge swissprot:LOIP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LOIP_ECOLI eggNOG COG0501 http://eggnogapi.embl.de/nog_data/html/tree/COG0501 eggNOG ENOG4108K0D http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108K0D epestfind swissprot:LOIP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LOIP_ECOLI garnier swissprot:LOIP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LOIP_ECOLI helixturnhelix swissprot:LOIP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LOIP_ECOLI hmoment swissprot:LOIP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LOIP_ECOLI iep swissprot:LOIP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LOIP_ECOLI inforesidue swissprot:LOIP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LOIP_ECOLI octanol swissprot:LOIP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LOIP_ECOLI pepcoil swissprot:LOIP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LOIP_ECOLI pepdigest swissprot:LOIP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LOIP_ECOLI pepinfo swissprot:LOIP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LOIP_ECOLI pepnet swissprot:LOIP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LOIP_ECOLI pepstats swissprot:LOIP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LOIP_ECOLI pepwheel swissprot:LOIP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LOIP_ECOLI pepwindow swissprot:LOIP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LOIP_ECOLI sigcleave swissprot:LOIP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LOIP_ECOLI ## Database ID URL or Descriptions # AltName ELAD_ECOLI Deubiquitinase # AltName ELAD_ECOLI Deubiquitinating enzyme # AltName ELAD_ECOLI Deubiquitinating protease # BioGrid 4261774 14 # EcoGene EG14261 elaD # FUNCTION ELAD_ECOLI Protease that can act as an efficient and specific deubiquitinating enzyme in vitro. Does not possess desumoylating and deneddylating activities. The physiological substrate is unknown. {ECO 0000269|PubMed 17440617}. # GO_function GO:0008234 cysteine-type peptidase activity; IMP:EcoCyc. # GO_process GO:0016579 protein deubiquitination; IDA:EcoCyc. # GOslim_function GO:0008233 peptidase activity # GOslim_process GO:0006464 cellular protein modification process # InterPro IPR003653 Peptidase_C48_C # Organism ELAD_ECOLI Escherichia coli (strain K12) # PATRIC 32119905 VBIEscCol129921_2362 # PIR C64998 C64998 # Pfam PF02902 Peptidase_C48 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ELAD_ECOLI Protease ElaD # RefSeq NP_416772 NC_000913.3 # SEQUENCE CAUTION Sequence=AAB02733.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the peptidase C79 family. {ECO 0000305}. # eggNOG ENOG4105Z6G Bacteria # eggNOG ENOG410XTR6 LUCA BLAST swissprot:ELAD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ELAD_ECOLI BioCyc ECOL316407:JW5840-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5840-MONOMER BioCyc EcoCyc:G7176-MONOMER http://biocyc.org/getid?id=EcoCyc:G7176-MONOMER BioCyc MetaCyc:G7176-MONOMER http://biocyc.org/getid?id=MetaCyc:G7176-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pone.0000381 http://dx.doi.org/10.1371/journal.pone.0000381 EC_number EC:3.4.22.- http://www.genome.jp/dbget-bin/www_bget?EC:3.4.22.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U58768 http://www.ebi.ac.uk/ena/data/view/U58768 ENZYME 3.4.22.- http://enzyme.expasy.org/EC/3.4.22.- EchoBASE EB4009 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4009 EcoGene EG14261 http://www.ecogene.org/geneInfo.php?eg_id=EG14261 EnsemblBacteria AAC75329 http://www.ensemblgenomes.org/id/AAC75329 EnsemblBacteria AAC75329 http://www.ensemblgenomes.org/id/AAC75329 EnsemblBacteria BAE76677 http://www.ensemblgenomes.org/id/BAE76677 EnsemblBacteria BAE76677 http://www.ensemblgenomes.org/id/BAE76677 EnsemblBacteria BAE76677 http://www.ensemblgenomes.org/id/BAE76677 EnsemblBacteria b2269 http://www.ensemblgenomes.org/id/b2269 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008234 GO_process GO:0016579 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016579 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GeneID 946742 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946742 HOGENOM HOG000054843 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000054843&db=HOGENOM6 IntEnz 3.4.22 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.22 InterPro IPR003653 http://www.ebi.ac.uk/interpro/entry/IPR003653 KEGG_Gene ecj:JW5840 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5840 KEGG_Gene eco:b2269 http://www.genome.jp/dbget-bin/www_bget?eco:b2269 OMA YRLSTPQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YRLSTPQ PSORT swissprot:ELAD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ELAD_ECOLI PSORT-B swissprot:ELAD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ELAD_ECOLI PSORT2 swissprot:ELAD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ELAD_ECOLI Pfam PF02902 http://pfam.xfam.org/family/PF02902 Phobius swissprot:ELAD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ELAD_ECOLI ProteinModelPortal Q47013 http://www.proteinmodelportal.org/query/uniprot/Q47013 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17440617 http://www.ncbi.nlm.nih.gov/pubmed/17440617 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416772 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416772 STRING 511145.b2269 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2269&targetmode=cogs UniProtKB ELAD_ECOLI http://www.uniprot.org/uniprot/ELAD_ECOLI UniProtKB-AC Q47013 http://www.uniprot.org/uniprot/Q47013 charge swissprot:ELAD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ELAD_ECOLI eggNOG ENOG4105Z6G http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105Z6G eggNOG ENOG410XTR6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XTR6 epestfind swissprot:ELAD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ELAD_ECOLI garnier swissprot:ELAD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ELAD_ECOLI helixturnhelix swissprot:ELAD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ELAD_ECOLI hmoment swissprot:ELAD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ELAD_ECOLI iep swissprot:ELAD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ELAD_ECOLI inforesidue swissprot:ELAD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ELAD_ECOLI octanol swissprot:ELAD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ELAD_ECOLI pepcoil swissprot:ELAD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ELAD_ECOLI pepdigest swissprot:ELAD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ELAD_ECOLI pepinfo swissprot:ELAD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ELAD_ECOLI pepnet swissprot:ELAD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ELAD_ECOLI pepstats swissprot:ELAD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ELAD_ECOLI pepwheel swissprot:ELAD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ELAD_ECOLI pepwindow swissprot:ELAD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ELAD_ECOLI sigcleave swissprot:ELAD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ELAD_ECOLI ## Database ID URL or Descriptions # AltName INTE_ECOLI Int(Lambda) # AltName INTE_ECOLI Prophage e14 integrase # AltName INTE_ECOLI Prophage lambda integrase # BioGrid 4263213 16 # EcoGene EG12370 intE # FUNCTION INTE_ECOLI Integrase from the cryptic lambdoic prophage e14. Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_function GO:0008907 integrase activity; IEA:InterPro. # GO_function GO:0046982 protein heterodimerization activity; IPI:UniProtKB. # GO_process GO:0006310 DNA recombination; IEA:UniProtKB-KW. # GO_process GO:0046718 viral entry into host cell; IEA:UniProtKB-KW. # GO_process GO:0075713 establishment of integrated proviral latency; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0044403 symbiosis, encompassing mutualism through parasitism # Gene3D 1.10.150.130 -; 1. # Gene3D 1.10.443.10 -; 1. # Gene3D 3.30.160.60 -; 1. # IntAct P75969 3 # InterPro IPR002104 Integrase_catalytic # InterPro IPR011010 DNA_brk_join_enz # InterPro IPR013087 Znf_C2H2/integrase_DNA-bd # InterPro IPR013762 Integrase-like_cat # InterPro IPR015094 Integrase_lambda-typ_DNA-bd_N # InterPro IPR016177 DNA-bd_dom # InterPro IPR023109 Integrase_recombinase_N # Organism INTE_ECOLI Escherichia coli (strain K12) # PATRIC 32117527 VBIEscCol129921_1186 # PIR A64859 A64859 # Pfam PF00589 Phage_integrase # Pfam PF09003 Phage_integ_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Prophage integrase IntE {ECO 0000305} # RefSeq NP_415658 NC_000913.3 # RefSeq WP_000741310 NZ_CP010440.1 # SIMILARITY Belongs to the 'phage' integrase family. {ECO 0000305}. # SUPFAM SSF54171 SSF54171 # SUPFAM SSF56349 SSF56349 # eggNOG COG0582 LUCA # eggNOG ENOG4108I1J Bacteria BLAST swissprot:INTE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INTE_ECOLI BioCyc ECOL316407:JW1126-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1126-MONOMER BioCyc EcoCyc:EG12370-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12370-MONOMER DIP DIP-10037N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10037N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2273 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2273 EcoGene EG12370 http://www.ecogene.org/geneInfo.php?eg_id=EG12370 EnsemblBacteria AAC74224 http://www.ensemblgenomes.org/id/AAC74224 EnsemblBacteria AAC74224 http://www.ensemblgenomes.org/id/AAC74224 EnsemblBacteria BAA35969 http://www.ensemblgenomes.org/id/BAA35969 EnsemblBacteria BAA35969 http://www.ensemblgenomes.org/id/BAA35969 EnsemblBacteria BAA35969 http://www.ensemblgenomes.org/id/BAA35969 EnsemblBacteria b1140 http://www.ensemblgenomes.org/id/b1140 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0008907 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008907 GO_function GO:0046982 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046982 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0046718 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046718 GO_process GO:0075713 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0075713 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0044403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403 Gene3D 1.10.150.130 http://www.cathdb.info/version/latest/superfamily/1.10.150.130 Gene3D 1.10.443.10 http://www.cathdb.info/version/latest/superfamily/1.10.443.10 Gene3D 3.30.160.60 http://www.cathdb.info/version/latest/superfamily/3.30.160.60 GeneID 948034 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948034 HOGENOM HOG000119139 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000119139&db=HOGENOM6 IntAct P75969 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75969* InterPro IPR002104 http://www.ebi.ac.uk/interpro/entry/IPR002104 InterPro IPR011010 http://www.ebi.ac.uk/interpro/entry/IPR011010 InterPro IPR013087 http://www.ebi.ac.uk/interpro/entry/IPR013087 InterPro IPR013762 http://www.ebi.ac.uk/interpro/entry/IPR013762 InterPro IPR015094 http://www.ebi.ac.uk/interpro/entry/IPR015094 InterPro IPR016177 http://www.ebi.ac.uk/interpro/entry/IPR016177 InterPro IPR023109 http://www.ebi.ac.uk/interpro/entry/IPR023109 KEGG_Gene ecj:JW1126 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1126 KEGG_Gene eco:b1140 http://www.genome.jp/dbget-bin/www_bget?eco:b1140 MINT MINT-1262950 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1262950 OMA QPRRKIT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QPRRKIT PSORT swissprot:INTE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INTE_ECOLI PSORT-B swissprot:INTE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INTE_ECOLI PSORT2 swissprot:INTE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INTE_ECOLI Pfam PF00589 http://pfam.xfam.org/family/PF00589 Pfam PF09003 http://pfam.xfam.org/family/PF09003 Phobius swissprot:INTE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INTE_ECOLI ProteinModelPortal P75969 http://www.proteinmodelportal.org/query/uniprot/P75969 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415658 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415658 RefSeq WP_000741310 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000741310 SMR P75969 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75969 STRING 511145.b1140 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1140&targetmode=cogs SUPFAM SSF54171 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54171 SUPFAM SSF56349 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56349 UniProtKB INTE_ECOLI http://www.uniprot.org/uniprot/INTE_ECOLI UniProtKB-AC P75969 http://www.uniprot.org/uniprot/P75969 charge swissprot:INTE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INTE_ECOLI eggNOG COG0582 http://eggnogapi.embl.de/nog_data/html/tree/COG0582 eggNOG ENOG4108I1J http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108I1J epestfind swissprot:INTE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INTE_ECOLI garnier swissprot:INTE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INTE_ECOLI helixturnhelix swissprot:INTE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INTE_ECOLI hmoment swissprot:INTE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INTE_ECOLI iep swissprot:INTE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INTE_ECOLI inforesidue swissprot:INTE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INTE_ECOLI octanol swissprot:INTE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INTE_ECOLI pepcoil swissprot:INTE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INTE_ECOLI pepdigest swissprot:INTE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INTE_ECOLI pepinfo swissprot:INTE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INTE_ECOLI pepnet swissprot:INTE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INTE_ECOLI pepstats swissprot:INTE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INTE_ECOLI pepwheel swissprot:INTE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INTE_ECOLI pepwindow swissprot:INTE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INTE_ECOLI sigcleave swissprot:INTE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INTE_ECOLI ## Database ID URL or Descriptions # BioGrid 4261393 8 # DISRUPTION PHENOTYPE Mutants are unable to use DNA as a sole carbon and energy source and show decreased competitive fitness when cocultured with wild-type cells. {ECO:0000269|PubMed 16707682}. # EcoGene EG12922 hofP # FUNCTION HOFP_ECOLI Required for the use of extracellular DNA as a nutrient. {ECO 0000269|PubMed 16707682}. # GO_process GO:0015976 carbon utilization; IMP:EcoCyc. # GOslim_process GO:0008150 biological_process # InterPro IPR019684 DUF2531 # KEGG_Brite ko02044 Secretion system # Organism HOFP_ECOLI Escherichia coli (strain K12) # PATRIC 32122216 VBIEscCol129921_3485 # PIR C65134 C65134 # Pfam PF10748 DUF2531 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HOFP_ECOLI Putative DNA utilization protein HofP # RefSeq NP_417851 NC_000913.3 # RefSeq WP_001264141 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA58189.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # eggNOG ENOG4105ITY Bacteria # eggNOG ENOG4111S65 LUCA BLAST swissprot:HOFP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HOFP_ECOLI BioCyc ECOL316407:JW5694-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5694-MONOMER BioCyc EcoCyc:G7736-MONOMER http://biocyc.org/getid?id=EcoCyc:G7736-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01974-05 http://dx.doi.org/10.1128/JB.01974-05 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2758 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2758 EcoGene EG12922 http://www.ecogene.org/geneInfo.php?eg_id=EG12922 EnsemblBacteria AAC76417 http://www.ensemblgenomes.org/id/AAC76417 EnsemblBacteria AAC76417 http://www.ensemblgenomes.org/id/AAC76417 EnsemblBacteria BAE77899 http://www.ensemblgenomes.org/id/BAE77899 EnsemblBacteria BAE77899 http://www.ensemblgenomes.org/id/BAE77899 EnsemblBacteria BAE77899 http://www.ensemblgenomes.org/id/BAE77899 EnsemblBacteria b3392 http://www.ensemblgenomes.org/id/b3392 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0015976 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015976 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 947900 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947900 HOGENOM HOG000268031 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000268031&db=HOGENOM6 InterPro IPR019684 http://www.ebi.ac.uk/interpro/entry/IPR019684 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW5694 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5694 KEGG_Gene eco:b3392 http://www.genome.jp/dbget-bin/www_bget?eco:b3392 KEGG_Orthology KO:K12291 http://www.genome.jp/dbget-bin/www_bget?KO:K12291 OMA QWRYQGI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QWRYQGI PSORT swissprot:HOFP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HOFP_ECOLI PSORT-B swissprot:HOFP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HOFP_ECOLI PSORT2 swissprot:HOFP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HOFP_ECOLI Pfam PF10748 http://pfam.xfam.org/family/PF10748 Phobius swissprot:HOFP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HOFP_ECOLI ProteinModelPortal P45750 http://www.proteinmodelportal.org/query/uniprot/P45750 PubMed 16707682 http://www.ncbi.nlm.nih.gov/pubmed/16707682 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417851 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417851 RefSeq WP_001264141 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001264141 STRING 511145.b3392 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3392&targetmode=cogs UniProtKB HOFP_ECOLI http://www.uniprot.org/uniprot/HOFP_ECOLI UniProtKB-AC P45750 http://www.uniprot.org/uniprot/P45750 charge swissprot:HOFP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HOFP_ECOLI eggNOG ENOG4105ITY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ITY eggNOG ENOG4111S65 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111S65 epestfind swissprot:HOFP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HOFP_ECOLI garnier swissprot:HOFP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HOFP_ECOLI helixturnhelix swissprot:HOFP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HOFP_ECOLI hmoment swissprot:HOFP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HOFP_ECOLI iep swissprot:HOFP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HOFP_ECOLI inforesidue swissprot:HOFP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HOFP_ECOLI octanol swissprot:HOFP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HOFP_ECOLI pepcoil swissprot:HOFP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HOFP_ECOLI pepdigest swissprot:HOFP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HOFP_ECOLI pepinfo swissprot:HOFP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HOFP_ECOLI pepnet swissprot:HOFP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HOFP_ECOLI pepstats swissprot:HOFP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HOFP_ECOLI pepwheel swissprot:HOFP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HOFP_ECOLI pepwindow swissprot:HOFP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HOFP_ECOLI sigcleave swissprot:HOFP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HOFP_ECOLI ## Database ID URL or Descriptions # AltName RNH_ECOLI Ribonuclease H # BRENDA 3.1.26 2026 # BioGrid 4263455 204 # CATALYTIC ACTIVITY RNH_ECOLI Endonucleolytic cleavage to 5'- phosphomonoester. # CDD cd09278 RNase_HI_prokaryote_like # COFACTOR RNH_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 9852071}; Note=Binds 1 Mg(2+) ion per subunit in the absence of substrate. Requires millimolar levels of Mg(2+) for maximal activity. Has low activity at micromolar concentrations of Mn(2+) and is inhibited at higher Mn(2+) levels. Can bind a second metal ion at a regulatory site, or after substrate binding. {ECO 0000269|PubMed 9852071}; # EcoGene EG10860 rnhA # FUNCTION RNH_ECOLI Endonuclease that specifically degrades the RNA of RNA- DNA hybrids. RNase H participates in DNA replication; it helps to specify the origin of genomic replication by suppressing initiation at origins other than the oriC locus; along with the 5'-3' exonuclease of pol1, it removes RNA primers from the Okazaki fragments of lagging strand synthesis; and it defines the origin of replication for ColE1-type plasmids by specific cleavage of an RNA preprimer. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0003676 nucleic acid binding; IDA:EcoliWiki. # GO_function GO:0004519 endonuclease activity; IDA:EcoliWiki. # GO_function GO:0004523 RNA-DNA hybrid ribonuclease activity; IDA:EcoCyc. # GO_process GO:0043137 DNA replication, removal of RNA primer; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0004518 nuclease activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # Gene3D 3.30.420.10 -; 1. # HAMAP MF_00042 RNase_H # IntAct P0A7Y4 21 # InterPro IPR002156 RNaseH_domain # InterPro IPR012337 RNaseH-like_dom # InterPro IPR022892 RNaseHI # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03032 DNA replication proteins # KEGG_Pathway ko03030 DNA replication # Organism RNH_ECOLI Escherichia coli (strain K12) # PATRIC 32115541 VBIEscCol129921_0216 # PDB 1F21 X-ray; 1.40 A; A=1-155 # PDB 1G15 X-ray; 1.90 A; A=1-155 # PDB 1GOA X-ray; 1.90 A; A=1-155 # PDB 1GOB X-ray; 2.00 A; A=1-155 # PDB 1GOC X-ray; 2.00 A; A=1-155 # PDB 1JL1 X-ray; 1.30 A; A=1-155 # PDB 1JL2 X-ray; 1.76 A; A/B/C/D=1-155 # PDB 1JXB X-ray; 1.60 A; A=1-155 # PDB 1KVA X-ray; 1.80 A; A=1-155 # PDB 1KVB X-ray; 1.90 A; A=1-155 # PDB 1KVC X-ray; 1.90 A; A=1-155 # PDB 1LAV X-ray; 1.80 A; A=1-155 # PDB 1LAW X-ray; 1.80 A; A=1-155 # PDB 1RBR X-ray; 1.80 A; A=1-155 # PDB 1RBS X-ray; 1.80 A; A=1-155 # PDB 1RBT X-ray; 1.80 A; A=1-155 # PDB 1RBU X-ray; 1.80 A; A=1-155 # PDB 1RBV X-ray; 1.80 A; A=1-155 # PDB 1RCH NMR; -; A=1-155 # PDB 1RDA X-ray; 2.15 A; A=1-155 # PDB 1RDB X-ray; 1.90 A; A=1-155 # PDB 1RDC X-ray; 2.30 A; A=1-155 # PDB 1RDD X-ray; 2.80 A; A=1-155 # PDB 1RNH X-ray; 2.00 A; A=1-155 # PDB 1WSE X-ray; 2.30 A; A/B=1-155 # PDB 1WSF X-ray; 2.30 A; A/B/C/D=1-155 # PDB 1WSG X-ray; 2.20 A; A/B/C/D=1-155 # PDB 1WSH X-ray; 1.90 A; A/B/C/D=1-155 # PDB 1WSI X-ray; 2.00 A; A/B/C/D=1-155 # PDB 1WSJ X-ray; 2.00 A; A/B/C/D/E/F/G/H=1-155 # PDB 2RN2 X-ray; 1.48 A; A=1-155 # PDB 2YV0 X-ray; 1.40 A; X=1-155 # PDB 2Z1G X-ray; 2.10 A; A=1-155 # PDB 2Z1H X-ray; 2.60 A; A=1-155 # PDB 2Z1I X-ray; 2.00 A; A/B=1-155 # PDB 2Z1J X-ray; 2.38 A; A=1-155 # PDB 3AA2 X-ray; 1.90 A; A=1-155 # PDB 3AA3 X-ray; 2.20 A; A=1-155 # PDB 3AA4 X-ray; 1.79 A; A=1-155 # PDB 3AA5 X-ray; 2.10 A; X=1-155 # PDB 3HYF X-ray; 1.70 A; A=79-102 # PDB 3QIN X-ray; 1.70 A; A=79-102 # PDB 3QIO X-ray; 1.40 A; A=79-102 # PDB 4Z0U X-ray; 2.00 A; A/B=1-155 # PIR A92401 NRECH # PROSITE PS50879 RNASE_H # Pfam PF00075 RNase_H # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RNH_ECOLI Ribonuclease HI # RefSeq NP_414750 NC_000913.3 # RefSeq WP_000917883 NZ_LN832404.1 # SIMILARITY Belongs to the RNase H family. {ECO 0000305}. # SIMILARITY Contains 1 RNase H domain. {ECO 0000305}. # SUBCELLULAR LOCATION RNH_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT RNH_ECOLI Monomer. {ECO 0000269|PubMed 11083878, ECO 0000269|PubMed 1311386, ECO 0000269|PubMed 15644213, ECO 0000269|PubMed 2169648}. # SUPFAM SSF53098 SSF53098 # eggNOG COG0328 LUCA # eggNOG ENOG4108UMW Bacteria BLAST swissprot:RNH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RNH_ECOLI BioCyc ECOL316407:JW0204-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0204-MONOMER BioCyc EcoCyc:EG10860-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10860-MONOMER BioCyc MetaCyc:EG10860-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10860-MONOMER COG COG0328 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0328 DIP DIP-47864N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47864N DOI 10.1016/0022-2836(86)90080-X http://dx.doi.org/10.1016/0022-2836(86)90080-X DOI 10.1016/0022-2836(92)90260-Q http://dx.doi.org/10.1016/0022-2836(92)90260-Q DOI 10.1016/j.jmb.2004.11.007 http://dx.doi.org/10.1016/j.jmb.2004.11.007 DOI 10.1021/bi00051a003 http://dx.doi.org/10.1021/bi00051a003 DOI 10.1021/bi00238a030 http://dx.doi.org/10.1021/bi00238a030 DOI 10.1038/347306a0 http://dx.doi.org/10.1038/347306a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2710059 http://dx.doi.org/10.1042/bj2710059 DOI 10.1073/pnas.80.23.7137 http://dx.doi.org/10.1073/pnas.80.23.7137 DOI 10.1074/jbc.273.51.34128 http://dx.doi.org/10.1074/jbc.273.51.34128 DOI 10.1074/jbc.M009626200 http://dx.doi.org/10.1074/jbc.M009626200 DOI 10.1093/protein/6.1.85 http://dx.doi.org/10.1093/protein/6.1.85 DOI 10.1093/protein/9.10.857 http://dx.doi.org/10.1093/protein/9.10.857 DOI 10.1110/ps.9.10.1914 http://dx.doi.org/10.1110/ps.9.10.1914 DOI 10.1126/science.2169648 http://dx.doi.org/10.1126/science.2169648 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.26.4 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.26.4 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K00985 http://www.ebi.ac.uk/ena/data/view/K00985 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EMBL V00337 http://www.ebi.ac.uk/ena/data/view/V00337 EMBL X04027 http://www.ebi.ac.uk/ena/data/view/X04027 ENZYME 3.1.26.4 http://enzyme.expasy.org/EC/3.1.26.4 EchoBASE EB0853 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0853 EcoGene EG10860 http://www.ecogene.org/geneInfo.php?eg_id=EG10860 EnsemblBacteria AAC73319 http://www.ensemblgenomes.org/id/AAC73319 EnsemblBacteria AAC73319 http://www.ensemblgenomes.org/id/AAC73319 EnsemblBacteria BAA77885 http://www.ensemblgenomes.org/id/BAA77885 EnsemblBacteria BAA77885 http://www.ensemblgenomes.org/id/BAA77885 EnsemblBacteria BAA77885 http://www.ensemblgenomes.org/id/BAA77885 EnsemblBacteria b0214 http://www.ensemblgenomes.org/id/b0214 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0003676 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003676 GO_function GO:0004519 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004519 GO_function GO:0004523 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004523 GO_process GO:0043137 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043137 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 Gene3D 3.30.420.10 http://www.cathdb.info/version/latest/superfamily/3.30.420.10 GeneID 946955 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946955 HAMAP MF_00042 http://hamap.expasy.org/unirule/MF_00042 HOGENOM HOG000040465 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000040465&db=HOGENOM6 InParanoid P0A7Y4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7Y4 IntAct P0A7Y4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7Y4* IntEnz 3.1.26.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.26.4 InterPro IPR002156 http://www.ebi.ac.uk/interpro/entry/IPR002156 InterPro IPR012337 http://www.ebi.ac.uk/interpro/entry/IPR012337 InterPro IPR022892 http://www.ebi.ac.uk/interpro/entry/IPR022892 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03032 http://www.genome.jp/dbget-bin/www_bget?ko03032 KEGG_Gene ecj:JW0204 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0204 KEGG_Gene eco:b0214 http://www.genome.jp/dbget-bin/www_bget?eco:b0214 KEGG_Orthology KO:K03469 http://www.genome.jp/dbget-bin/www_bget?KO:K03469 KEGG_Pathway ko03030 http://www.genome.jp/kegg-bin/show_pathway?ko03030 MINT MINT-1224022 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1224022 OMA LVTDSQY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LVTDSQY PDB 1F21 http://www.ebi.ac.uk/pdbe-srv/view/entry/1F21 PDB 1G15 http://www.ebi.ac.uk/pdbe-srv/view/entry/1G15 PDB 1GOA http://www.ebi.ac.uk/pdbe-srv/view/entry/1GOA PDB 1GOB http://www.ebi.ac.uk/pdbe-srv/view/entry/1GOB PDB 1GOC http://www.ebi.ac.uk/pdbe-srv/view/entry/1GOC PDB 1JL1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1JL1 PDB 1JL2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1JL2 PDB 1JXB http://www.ebi.ac.uk/pdbe-srv/view/entry/1JXB PDB 1KVA http://www.ebi.ac.uk/pdbe-srv/view/entry/1KVA PDB 1KVB http://www.ebi.ac.uk/pdbe-srv/view/entry/1KVB PDB 1KVC http://www.ebi.ac.uk/pdbe-srv/view/entry/1KVC PDB 1LAV http://www.ebi.ac.uk/pdbe-srv/view/entry/1LAV PDB 1LAW http://www.ebi.ac.uk/pdbe-srv/view/entry/1LAW PDB 1RBR http://www.ebi.ac.uk/pdbe-srv/view/entry/1RBR PDB 1RBS http://www.ebi.ac.uk/pdbe-srv/view/entry/1RBS PDB 1RBT http://www.ebi.ac.uk/pdbe-srv/view/entry/1RBT PDB 1RBU http://www.ebi.ac.uk/pdbe-srv/view/entry/1RBU PDB 1RBV http://www.ebi.ac.uk/pdbe-srv/view/entry/1RBV PDB 1RCH http://www.ebi.ac.uk/pdbe-srv/view/entry/1RCH PDB 1RDA http://www.ebi.ac.uk/pdbe-srv/view/entry/1RDA PDB 1RDB http://www.ebi.ac.uk/pdbe-srv/view/entry/1RDB PDB 1RDC http://www.ebi.ac.uk/pdbe-srv/view/entry/1RDC PDB 1RDD http://www.ebi.ac.uk/pdbe-srv/view/entry/1RDD PDB 1RNH http://www.ebi.ac.uk/pdbe-srv/view/entry/1RNH PDB 1WSE http://www.ebi.ac.uk/pdbe-srv/view/entry/1WSE PDB 1WSF http://www.ebi.ac.uk/pdbe-srv/view/entry/1WSF PDB 1WSG http://www.ebi.ac.uk/pdbe-srv/view/entry/1WSG PDB 1WSH http://www.ebi.ac.uk/pdbe-srv/view/entry/1WSH PDB 1WSI http://www.ebi.ac.uk/pdbe-srv/view/entry/1WSI PDB 1WSJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1WSJ PDB 2RN2 http://www.ebi.ac.uk/pdbe-srv/view/entry/2RN2 PDB 2YV0 http://www.ebi.ac.uk/pdbe-srv/view/entry/2YV0 PDB 2Z1G http://www.ebi.ac.uk/pdbe-srv/view/entry/2Z1G PDB 2Z1H http://www.ebi.ac.uk/pdbe-srv/view/entry/2Z1H PDB 2Z1I http://www.ebi.ac.uk/pdbe-srv/view/entry/2Z1I PDB 2Z1J http://www.ebi.ac.uk/pdbe-srv/view/entry/2Z1J PDB 3AA2 http://www.ebi.ac.uk/pdbe-srv/view/entry/3AA2 PDB 3AA3 http://www.ebi.ac.uk/pdbe-srv/view/entry/3AA3 PDB 3AA4 http://www.ebi.ac.uk/pdbe-srv/view/entry/3AA4 PDB 3AA5 http://www.ebi.ac.uk/pdbe-srv/view/entry/3AA5 PDB 3HYF http://www.ebi.ac.uk/pdbe-srv/view/entry/3HYF PDB 3QIN http://www.ebi.ac.uk/pdbe-srv/view/entry/3QIN PDB 3QIO http://www.ebi.ac.uk/pdbe-srv/view/entry/3QIO PDB 4Z0U http://www.ebi.ac.uk/pdbe-srv/view/entry/4Z0U PDBsum 1F21 http://www.ebi.ac.uk/pdbsum/1F21 PDBsum 1G15 http://www.ebi.ac.uk/pdbsum/1G15 PDBsum 1GOA http://www.ebi.ac.uk/pdbsum/1GOA PDBsum 1GOB http://www.ebi.ac.uk/pdbsum/1GOB PDBsum 1GOC http://www.ebi.ac.uk/pdbsum/1GOC PDBsum 1JL1 http://www.ebi.ac.uk/pdbsum/1JL1 PDBsum 1JL2 http://www.ebi.ac.uk/pdbsum/1JL2 PDBsum 1JXB http://www.ebi.ac.uk/pdbsum/1JXB PDBsum 1KVA http://www.ebi.ac.uk/pdbsum/1KVA PDBsum 1KVB http://www.ebi.ac.uk/pdbsum/1KVB PDBsum 1KVC http://www.ebi.ac.uk/pdbsum/1KVC PDBsum 1LAV http://www.ebi.ac.uk/pdbsum/1LAV PDBsum 1LAW http://www.ebi.ac.uk/pdbsum/1LAW PDBsum 1RBR http://www.ebi.ac.uk/pdbsum/1RBR PDBsum 1RBS http://www.ebi.ac.uk/pdbsum/1RBS PDBsum 1RBT http://www.ebi.ac.uk/pdbsum/1RBT PDBsum 1RBU http://www.ebi.ac.uk/pdbsum/1RBU PDBsum 1RBV http://www.ebi.ac.uk/pdbsum/1RBV PDBsum 1RCH http://www.ebi.ac.uk/pdbsum/1RCH PDBsum 1RDA http://www.ebi.ac.uk/pdbsum/1RDA PDBsum 1RDB http://www.ebi.ac.uk/pdbsum/1RDB PDBsum 1RDC http://www.ebi.ac.uk/pdbsum/1RDC PDBsum 1RDD http://www.ebi.ac.uk/pdbsum/1RDD PDBsum 1RNH http://www.ebi.ac.uk/pdbsum/1RNH PDBsum 1WSE http://www.ebi.ac.uk/pdbsum/1WSE PDBsum 1WSF http://www.ebi.ac.uk/pdbsum/1WSF PDBsum 1WSG http://www.ebi.ac.uk/pdbsum/1WSG PDBsum 1WSH http://www.ebi.ac.uk/pdbsum/1WSH PDBsum 1WSI http://www.ebi.ac.uk/pdbsum/1WSI PDBsum 1WSJ http://www.ebi.ac.uk/pdbsum/1WSJ PDBsum 2RN2 http://www.ebi.ac.uk/pdbsum/2RN2 PDBsum 2YV0 http://www.ebi.ac.uk/pdbsum/2YV0 PDBsum 2Z1G http://www.ebi.ac.uk/pdbsum/2Z1G PDBsum 2Z1H http://www.ebi.ac.uk/pdbsum/2Z1H PDBsum 2Z1I http://www.ebi.ac.uk/pdbsum/2Z1I PDBsum 2Z1J http://www.ebi.ac.uk/pdbsum/2Z1J PDBsum 3AA2 http://www.ebi.ac.uk/pdbsum/3AA2 PDBsum 3AA3 http://www.ebi.ac.uk/pdbsum/3AA3 PDBsum 3AA4 http://www.ebi.ac.uk/pdbsum/3AA4 PDBsum 3AA5 http://www.ebi.ac.uk/pdbsum/3AA5 PDBsum 3HYF http://www.ebi.ac.uk/pdbsum/3HYF PDBsum 3QIN http://www.ebi.ac.uk/pdbsum/3QIN PDBsum 3QIO http://www.ebi.ac.uk/pdbsum/3QIO PDBsum 4Z0U http://www.ebi.ac.uk/pdbsum/4Z0U PROSITE PS50879 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50879 PSORT swissprot:RNH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RNH_ECOLI PSORT-B swissprot:RNH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RNH_ECOLI PSORT2 swissprot:RNH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RNH_ECOLI Pfam PF00075 http://pfam.xfam.org/family/PF00075 Phobius swissprot:RNH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RNH_ECOLI PhylomeDB P0A7Y4 http://phylomedb.org/?seqid=P0A7Y4 ProteinModelPortal P0A7Y4 http://www.proteinmodelportal.org/query/uniprot/P0A7Y4 PubMed 11083878 http://www.ncbi.nlm.nih.gov/pubmed/11083878 PubMed 11106164 http://www.ncbi.nlm.nih.gov/pubmed/11106164 PubMed 1311386 http://www.ncbi.nlm.nih.gov/pubmed/1311386 PubMed 15644213 http://www.ncbi.nlm.nih.gov/pubmed/15644213 PubMed 1646006 http://www.ncbi.nlm.nih.gov/pubmed/1646006 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1689729 http://www.ncbi.nlm.nih.gov/pubmed/1689729 PubMed 1698262 http://www.ncbi.nlm.nih.gov/pubmed/1698262 PubMed 2169648 http://www.ncbi.nlm.nih.gov/pubmed/2169648 PubMed 2171503 http://www.ncbi.nlm.nih.gov/pubmed/2171503 PubMed 3023634 http://www.ncbi.nlm.nih.gov/pubmed/3023634 PubMed 6296074 http://www.ncbi.nlm.nih.gov/pubmed/6296074 PubMed 6302075 http://www.ncbi.nlm.nih.gov/pubmed/6302075 PubMed 6316347 http://www.ncbi.nlm.nih.gov/pubmed/6316347 PubMed 8381958 http://www.ncbi.nlm.nih.gov/pubmed/8381958 PubMed 8408067 http://www.ncbi.nlm.nih.gov/pubmed/8408067 PubMed 8527428 http://www.ncbi.nlm.nih.gov/pubmed/8527428 PubMed 8931125 http://www.ncbi.nlm.nih.gov/pubmed/8931125 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9852071 http://www.ncbi.nlm.nih.gov/pubmed/9852071 RefSeq NP_414750 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414750 RefSeq WP_000917883 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000917883 SMR P0A7Y4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7Y4 STRING 511145.b0214 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0214&targetmode=cogs STRING COG0328 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0328&targetmode=cogs SUPFAM SSF53098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098 UniProtKB RNH_ECOLI http://www.uniprot.org/uniprot/RNH_ECOLI UniProtKB-AC P0A7Y4 http://www.uniprot.org/uniprot/P0A7Y4 charge swissprot:RNH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RNH_ECOLI eggNOG COG0328 http://eggnogapi.embl.de/nog_data/html/tree/COG0328 eggNOG ENOG4108UMW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UMW epestfind swissprot:RNH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RNH_ECOLI garnier swissprot:RNH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RNH_ECOLI helixturnhelix swissprot:RNH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RNH_ECOLI hmoment swissprot:RNH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RNH_ECOLI iep swissprot:RNH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RNH_ECOLI inforesidue swissprot:RNH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RNH_ECOLI octanol swissprot:RNH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RNH_ECOLI pepcoil swissprot:RNH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RNH_ECOLI pepdigest swissprot:RNH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RNH_ECOLI pepinfo swissprot:RNH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RNH_ECOLI pepnet swissprot:RNH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RNH_ECOLI pepstats swissprot:RNH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RNH_ECOLI pepwheel swissprot:RNH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RNH_ECOLI pepwindow swissprot:RNH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RNH_ECOLI sigcleave swissprot:RNH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RNH_ECOLI ## Database ID URL or Descriptions # BioGrid 4261465 163 # EcoGene EG12608 caiE # FUNCTION CAIE_ECOLI Overproduction of CaiE stimulates the activity of CaiB and CaiD. {ECO 0000269|PubMed 7815937}. # GO_function GO:0008735 carnitine dehydratase activity; EXP:EcoliWiki. # GO_function GO:0016740 transferase activity; IEA:UniProtKB-KW. # GO_process GO:0009437 carnitine metabolic process; EXP:EcoliWiki. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # HAMAP MF_01525 CaiE # InterPro IPR001451 Hexapep # InterPro IPR011004 Trimer_LpxA-like # InterPro IPR023446 CaiE # Organism CAIE_ECOLI Escherichia coli (strain K12) # PATHWAY CAIE_ECOLI Amine and polyamine metabolism; carnitine metabolism. # PATRIC 32115165 VBIEscCol129921_0034 # PIR C64724 C64724 # Pfam PF00132 Hexapep; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CAIE_ECOLI Carnitine operon protein CaiE # RefSeq NP_414577 NC_000913.3 # RefSeq WP_000122871 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA52115.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the transferase hexapeptide repeat family. {ECO 0000305}. # SUPFAM SSF51161 SSF51161 # eggNOG COG0663 LUCA # eggNOG ENOG4108Z0R Bacteria BLAST swissprot:CAIE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CAIE_ECOLI BioCyc ECOL316407:JW5004-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5004-MONOMER BioCyc EcoCyc:CAIE-MONOMER http://biocyc.org/getid?id=EcoCyc:CAIE-MONOMER BioCyc MetaCyc:CAIE-MONOMER http://biocyc.org/getid?id=MetaCyc:CAIE-MONOMER COG COG0663 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0663 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1111/j.1365-2958.1994.tb00470.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb00470.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X73904 http://www.ebi.ac.uk/ena/data/view/X73904 EchoBASE EB2492 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2492 EcoGene EG12608 http://www.ecogene.org/geneInfo.php?eg_id=EG12608 EnsemblBacteria AAC73146 http://www.ensemblgenomes.org/id/AAC73146 EnsemblBacteria AAC73146 http://www.ensemblgenomes.org/id/AAC73146 EnsemblBacteria BAB96604 http://www.ensemblgenomes.org/id/BAB96604 EnsemblBacteria BAB96604 http://www.ensemblgenomes.org/id/BAB96604 EnsemblBacteria BAB96604 http://www.ensemblgenomes.org/id/BAB96604 EnsemblBacteria b0035 http://www.ensemblgenomes.org/id/b0035 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008735 GO_function GO:0016740 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016740 GO_process GO:0009437 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009437 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 948999 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948999 HAMAP MF_01525 http://hamap.expasy.org/unirule/MF_01525 HOGENOM HOG000049430 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000049430&db=HOGENOM6 InParanoid P39206 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39206 InterPro IPR001451 http://www.ebi.ac.uk/interpro/entry/IPR001451 InterPro IPR011004 http://www.ebi.ac.uk/interpro/entry/IPR011004 InterPro IPR023446 http://www.ebi.ac.uk/interpro/entry/IPR023446 KEGG_Gene ecj:JW5004 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5004 KEGG_Gene eco:b0035 http://www.genome.jp/dbget-bin/www_bget?eco:b0035 KEGG_Orthology KO:K08279 http://www.genome.jp/dbget-bin/www_bget?KO:K08279 OMA CYEFEGL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CYEFEGL PSORT swissprot:CAIE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CAIE_ECOLI PSORT-B swissprot:CAIE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CAIE_ECOLI PSORT2 swissprot:CAIE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CAIE_ECOLI Pfam PF00132 http://pfam.xfam.org/family/PF00132 Phobius swissprot:CAIE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CAIE_ECOLI PhylomeDB P39206 http://phylomedb.org/?seqid=P39206 ProteinModelPortal P39206 http://www.proteinmodelportal.org/query/uniprot/P39206 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7815937 http://www.ncbi.nlm.nih.gov/pubmed/7815937 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414577 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414577 RefSeq WP_000122871 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000122871 SMR P39206 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39206 STRING 511145.b0035 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0035&targetmode=cogs STRING COG0663 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0663&targetmode=cogs SUPFAM SSF51161 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51161 UniProtKB CAIE_ECOLI http://www.uniprot.org/uniprot/CAIE_ECOLI UniProtKB-AC P39206 http://www.uniprot.org/uniprot/P39206 charge swissprot:CAIE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CAIE_ECOLI eggNOG COG0663 http://eggnogapi.embl.de/nog_data/html/tree/COG0663 eggNOG ENOG4108Z0R http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Z0R epestfind swissprot:CAIE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CAIE_ECOLI garnier swissprot:CAIE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CAIE_ECOLI helixturnhelix swissprot:CAIE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CAIE_ECOLI hmoment swissprot:CAIE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CAIE_ECOLI iep swissprot:CAIE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CAIE_ECOLI inforesidue swissprot:CAIE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CAIE_ECOLI octanol swissprot:CAIE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CAIE_ECOLI pepcoil swissprot:CAIE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CAIE_ECOLI pepdigest swissprot:CAIE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CAIE_ECOLI pepinfo swissprot:CAIE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CAIE_ECOLI pepnet swissprot:CAIE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CAIE_ECOLI pepstats swissprot:CAIE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CAIE_ECOLI pepwheel swissprot:CAIE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CAIE_ECOLI pepwindow swissprot:CAIE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CAIE_ECOLI sigcleave swissprot:CAIE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CAIE_ECOLI ## Database ID URL or Descriptions # BioGrid 4261257 251 # EcoGene EG20254 sapA # FUNCTION SAPA_ECOLI Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IBA:GO_Central. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IEA:InterPro. # GO_function GO:0015197 peptide transporter activity; IBA:GO_Central. # GO_process GO:0015031 protein transport; IEA:UniProtKB-KW. # GO_process GO:0055085 transmembrane transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # IntAct Q47622 5 # InterPro IPR000914 SBP_5_dom # InterPro IPR023765 SBP_5_CS # InterPro IPR030678 Peptide/Ni-bd # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00324 Dipeptide transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # KEGG_Pathway ko02030 Bacterial chemotaxis # Organism SAPA_ECOLI Escherichia coli (strain K12) # PATRIC 32117858 VBIEscCol129921_1349 # PIR A64878 A64878 # PIRSF PIRSF002741 MppA # PROSITE PS01040 SBP_BACTERIAL_5 # Pfam PF00496 SBP_bac_5 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SAPA_ECOLI Peptide transport periplasmic protein SapA # RefSeq NP_415810 NC_000913.3 # RefSeq WP_001250216 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial solute-binding protein 5 family. {ECO 0000305}. # SUBCELLULAR LOCATION SAPA_ECOLI Periplasm {ECO 0000305}. # TCDB 3.A.1.5.42 the atp-binding cassette (abc) superfamily # eggNOG COG4166 LUCA # eggNOG ENOG4108HIY Bacteria BLAST swissprot:SAPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SAPA_ECOLI BioCyc ECOL316407:JW1287-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1287-MONOMER BioCyc EcoCyc:SAPA-MONOMER http://biocyc.org/getid?id=EcoCyc:SAPA-MONOMER COG COG0747 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0747 DIP DIP-10822N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10822N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X97282 http://www.ebi.ac.uk/ena/data/view/X97282 EchoBASE EB4155 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4155 EcoGene EG20254 http://www.ecogene.org/geneInfo.php?eg_id=EG20254 EnsemblBacteria AAC74376 http://www.ensemblgenomes.org/id/AAC74376 EnsemblBacteria AAC74376 http://www.ensemblgenomes.org/id/AAC74376 EnsemblBacteria BAA14855 http://www.ensemblgenomes.org/id/BAA14855 EnsemblBacteria BAA14855 http://www.ensemblgenomes.org/id/BAA14855 EnsemblBacteria BAA14855 http://www.ensemblgenomes.org/id/BAA14855 EnsemblBacteria b1294 http://www.ensemblgenomes.org/id/b1294 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0015197 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015197 GO_process GO:0015031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 945873 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945873 HOGENOM HOG000164955 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000164955&db=HOGENOM6 InParanoid Q47622 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q47622 IntAct Q47622 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q47622* InterPro IPR000914 http://www.ebi.ac.uk/interpro/entry/IPR000914 InterPro IPR023765 http://www.ebi.ac.uk/interpro/entry/IPR023765 InterPro IPR030678 http://www.ebi.ac.uk/interpro/entry/IPR030678 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1287 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1287 KEGG_Gene eco:b1294 http://www.genome.jp/dbget-bin/www_bget?eco:b1294 KEGG_Orthology KO:K12368 http://www.genome.jp/dbget-bin/www_bget?KO:K12368 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 KEGG_Pathway ko02030 http://www.genome.jp/kegg-bin/show_pathway?ko02030 MINT MINT-1292044 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1292044 OMA FDISHRG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FDISHRG PROSITE PS01040 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01040 PSORT swissprot:SAPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SAPA_ECOLI PSORT-B swissprot:SAPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SAPA_ECOLI PSORT2 swissprot:SAPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SAPA_ECOLI Pfam PF00496 http://pfam.xfam.org/family/PF00496 Phobius swissprot:SAPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SAPA_ECOLI PhylomeDB Q47622 http://phylomedb.org/?seqid=Q47622 ProteinModelPortal Q47622 http://www.proteinmodelportal.org/query/uniprot/Q47622 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415810 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415810 RefSeq WP_001250216 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001250216 SMR Q47622 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q47622 STRING 511145.b1294 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1294&targetmode=cogs STRING COG0747 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0747&targetmode=cogs TCDB 3.A.1.5.42 http://www.tcdb.org/search/result.php?tc=3.A.1.5.42 UniProtKB SAPA_ECOLI http://www.uniprot.org/uniprot/SAPA_ECOLI UniProtKB-AC Q47622 http://www.uniprot.org/uniprot/Q47622 charge swissprot:SAPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SAPA_ECOLI eggNOG COG4166 http://eggnogapi.embl.de/nog_data/html/tree/COG4166 eggNOG ENOG4108HIY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108HIY epestfind swissprot:SAPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SAPA_ECOLI garnier swissprot:SAPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SAPA_ECOLI helixturnhelix swissprot:SAPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SAPA_ECOLI hmoment swissprot:SAPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SAPA_ECOLI iep swissprot:SAPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SAPA_ECOLI inforesidue swissprot:SAPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SAPA_ECOLI octanol swissprot:SAPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SAPA_ECOLI pepcoil swissprot:SAPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SAPA_ECOLI pepdigest swissprot:SAPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SAPA_ECOLI pepinfo swissprot:SAPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SAPA_ECOLI pepnet swissprot:SAPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SAPA_ECOLI pepstats swissprot:SAPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SAPA_ECOLI pepwheel swissprot:SAPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SAPA_ECOLI pepwindow swissprot:SAPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SAPA_ECOLI sigcleave swissprot:SAPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SAPA_ECOLI ## Database ID URL or Descriptions # AltName METB_ECOLI O-succinylhomoserine (thiol)-lyase # BIOPHYSICOCHEMICAL PROPERTIES METB_ECOLI Kinetic parameters KM=0.33 mM for O-succinyl-L-homoserine (at pH 8.2 and 25 degrees Celsius, when assaying the gamma-elimination reaction) {ECO 0000269|PubMed 2405903}; KM=1.0 mM for O-succinyl-L-homoserine (at pH 8.2 and 25 degrees Celsius, when assaying the gamma-replacement reaction) {ECO 0000269|PubMed 2405903}; KM=0.05 mM for L-cysteine (at pH 8.2 and 25 degrees Celsius, when assaying the gamma-replacement reaction) {ECO 0000269|PubMed 2405903}; Note=kcat are 700 min(-1) and 460 min (-1) for the gamma- replacement and gamma-elimination reaction, respectively.; pH dependence Optimum pH is 7.8 for the gamma-replacement reaction. {ECO 0000269|PubMed 2405903}; # BRENDA 2.5.1.48 2026 # BioGrid 4261102 18 # CATALYTIC ACTIVITY O(4)-succinyl-L-homoserine + L-cysteine = L- cystathionine + succinate. {ECO:0000269|PubMed 2405903}. # CDD cd00614 CGS_like # COFACTOR METB_ECOLI Name=pyridoxal 5'-phosphate; Xref=ChEBI CHEBI 597326; Evidence={ECO 0000269|PubMed 2405903}; Note=Binds 1 pyridoxal phosphate per subunit. {ECO 0000269|PubMed 2405903}; # EcoGene EG10582 metB # FUNCTION METB_ECOLI Catalyzes the formation of L-cystathionine from O- succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma- replacement reaction. In the absence of thiol, catalyzes gamma- elimination to form 2-oxobutanoate, succinate and ammonia. {ECO 0000269|PubMed 2405903}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0003962 cystathionine gamma-synthase activity; IDA:EcoCyc. # GO_function GO:0004123 cystathionine gamma-lyase activity; IBA:GO_Central. # GO_function GO:0030170 pyridoxal phosphate binding; IDA:EcoCyc. # GO_process GO:0009086 methionine biosynthetic process; IMP:EcoCyc. # GO_process GO:0019343 cysteine biosynthetic process via cystathionine; IBA:GO_Central. # GO_process GO:0019346 transsulfuration; IBA:GO_Central. # GO_process GO:0071266 'de novo' L-methionine biosynthetic process; IBA:GO_Central. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.640.10 -; 1. # Gene3D 3.90.1150.10 -; 1. # InterPro IPR000277 Cys/Met-Metab_PyrdxlP-dep_enz # InterPro IPR011821 O_succ_thio_ly # InterPro IPR015421 PyrdxlP-dep_Trfase_major_sub1 # InterPro IPR015422 PyrdxlP-dep_Trfase_major_sub2 # InterPro IPR015424 PyrdxlP-dep_Trfase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00270 Cysteine and methionine metabolism # KEGG_Pathway ko00450 Selenocompound metabolism # KEGG_Pathway ko00920 Sulfur metabolism # Organism METB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11808 PTHR11808 # PATHWAY Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-cystathionine from O-succinyl-L-homoserine step 1/1. # PATRIC 32123397 VBIEscCol129921_4059 # PDB 1CS1 X-ray; 1.50 A; A/B/C/D=1-386 # PIR A01158 SYECCG # PIRSF PIRSF001434 CGS # PROSITE PS00868 CYS_MET_METAB_PP # Pfam PF01053 Cys_Met_Meta_PP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName METB_ECOLI Cystathionine gamma-synthase # RefSeq NP_418374 NC_000913.3 # RefSeq WP_001295694 NZ_LN832404.1 # SIMILARITY Belongs to the trans-sulfuration enzymes family. {ECO 0000305}. # SUBCELLULAR LOCATION METB_ECOLI Cytoplasm. # SUBUNIT METB_ECOLI Homotetramer. {ECO 0000269|PubMed 2405903, ECO 0000269|PubMed 9843488}. # SUPFAM SSF53383 SSF53383 # TIGRFAMs TIGR02080 O_succ_thio_ly # UniPathway UPA00051 UER00077 # eggNOG COG0626 LUCA # eggNOG ENOG4105C28 Bacteria BLAST swissprot:METB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:METB_ECOLI BioCyc ECOL316407:JW3910-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3910-MONOMER BioCyc EcoCyc:O-SUCCHOMOSERLYASE-MONOMER http://biocyc.org/getid?id=EcoCyc:O-SUCCHOMOSERLYASE-MONOMER BioCyc MetaCyc:O-SUCCHOMOSERLYASE-MONOMER http://biocyc.org/getid?id=MetaCyc:O-SUCCHOMOSERLYASE-MONOMER COG COG0626 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0626 DIP DIP-10192N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10192N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0006-291X(87)90968-5 http://dx.doi.org/10.1016/0006-291X(87)90968-5 DOI 10.1021/bi00454a019 http://dx.doi.org/10.1021/bi00454a019 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/emboj/17.23.6827 http://dx.doi.org/10.1093/emboj/17.23.6827 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.5.1.48 http://www.genome.jp/dbget-bin/www_bget?EC:2.5.1.48 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K01546 http://www.ebi.ac.uk/ena/data/view/K01546 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.5.1.48 http://enzyme.expasy.org/EC/2.5.1.48 EchoBASE EB0577 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0577 EcoGene EG10582 http://www.ecogene.org/geneInfo.php?eg_id=EG10582 EnsemblBacteria AAC76921 http://www.ensemblgenomes.org/id/AAC76921 EnsemblBacteria AAC76921 http://www.ensemblgenomes.org/id/AAC76921 EnsemblBacteria BAE77371 http://www.ensemblgenomes.org/id/BAE77371 EnsemblBacteria BAE77371 http://www.ensemblgenomes.org/id/BAE77371 EnsemblBacteria BAE77371 http://www.ensemblgenomes.org/id/BAE77371 EnsemblBacteria b3939 http://www.ensemblgenomes.org/id/b3939 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003962 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003962 GO_function GO:0004123 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004123 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_process GO:0009086 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009086 GO_process GO:0019343 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019343 GO_process GO:0019346 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019346 GO_process GO:0071266 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071266 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016765 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.640.10 http://www.cathdb.info/version/latest/superfamily/3.40.640.10 Gene3D 3.90.1150.10 http://www.cathdb.info/version/latest/superfamily/3.90.1150.10 GeneID 948434 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948434 HOGENOM HOG000246415 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000246415&db=HOGENOM6 InParanoid P00935 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00935 IntAct P00935 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00935* IntEnz 2.5.1.48 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.5.1.48 InterPro IPR000277 http://www.ebi.ac.uk/interpro/entry/IPR000277 InterPro IPR011821 http://www.ebi.ac.uk/interpro/entry/IPR011821 InterPro IPR015421 http://www.ebi.ac.uk/interpro/entry/IPR015421 InterPro IPR015422 http://www.ebi.ac.uk/interpro/entry/IPR015422 InterPro IPR015424 http://www.ebi.ac.uk/interpro/entry/IPR015424 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3910 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3910 KEGG_Gene eco:b3939 http://www.genome.jp/dbget-bin/www_bget?eco:b3939 KEGG_Orthology KO:K01739 http://www.genome.jp/dbget-bin/www_bget?KO:K01739 KEGG_Pathway ko00270 http://www.genome.jp/kegg-bin/show_pathway?ko00270 KEGG_Pathway ko00450 http://www.genome.jp/kegg-bin/show_pathway?ko00450 KEGG_Pathway ko00920 http://www.genome.jp/kegg-bin/show_pathway?ko00920 KEGG_Reaction rn:R00999 http://www.genome.jp/dbget-bin/www_bget?rn:R00999 KEGG_Reaction rn:R01288 http://www.genome.jp/dbget-bin/www_bget?rn:R01288 KEGG_Reaction rn:R02508 http://www.genome.jp/dbget-bin/www_bget?rn:R02508 KEGG_Reaction rn:R03132 http://www.genome.jp/dbget-bin/www_bget?rn:R03132 KEGG_Reaction rn:R03217 http://www.genome.jp/dbget-bin/www_bget?rn:R03217 KEGG_Reaction rn:R03260 http://www.genome.jp/dbget-bin/www_bget?rn:R03260 KEGG_Reaction rn:R04944 http://www.genome.jp/dbget-bin/www_bget?rn:R04944 KEGG_Reaction rn:R04945 http://www.genome.jp/dbget-bin/www_bget?rn:R04945 KEGG_Reaction rn:R04946 http://www.genome.jp/dbget-bin/www_bget?rn:R04946 OMA THACIPK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=THACIPK PANTHER PTHR11808 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11808 PDB 1CS1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1CS1 PDBsum 1CS1 http://www.ebi.ac.uk/pdbsum/1CS1 PROSITE PS00868 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00868 PSORT swissprot:METB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:METB_ECOLI PSORT-B swissprot:METB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:METB_ECOLI PSORT2 swissprot:METB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:METB_ECOLI Pfam PF01053 http://pfam.xfam.org/family/PF01053 Phobius swissprot:METB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:METB_ECOLI PhylomeDB P00935 http://phylomedb.org/?seqid=P00935 ProteinModelPortal P00935 http://www.proteinmodelportal.org/query/uniprot/P00935 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2405903 http://www.ncbi.nlm.nih.gov/pubmed/2405903 PubMed 3307782 http://www.ncbi.nlm.nih.gov/pubmed/3307782 PubMed 6361020 http://www.ncbi.nlm.nih.gov/pubmed/6361020 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9843488 http://www.ncbi.nlm.nih.gov/pubmed/9843488 RefSeq NP_418374 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418374 RefSeq WP_001295694 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295694 SMR P00935 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00935 STRING 511145.b3939 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3939&targetmode=cogs STRING COG0626 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0626&targetmode=cogs SUPFAM SSF53383 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53383 TIGRFAMs TIGR02080 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02080 UniProtKB METB_ECOLI http://www.uniprot.org/uniprot/METB_ECOLI UniProtKB-AC P00935 http://www.uniprot.org/uniprot/P00935 charge swissprot:METB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:METB_ECOLI eggNOG COG0626 http://eggnogapi.embl.de/nog_data/html/tree/COG0626 eggNOG ENOG4105C28 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C28 epestfind swissprot:METB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:METB_ECOLI garnier swissprot:METB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:METB_ECOLI helixturnhelix swissprot:METB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:METB_ECOLI hmoment swissprot:METB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:METB_ECOLI iep swissprot:METB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:METB_ECOLI inforesidue swissprot:METB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:METB_ECOLI octanol swissprot:METB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:METB_ECOLI pepcoil swissprot:METB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:METB_ECOLI pepdigest swissprot:METB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:METB_ECOLI pepinfo swissprot:METB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:METB_ECOLI pepnet swissprot:METB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:METB_ECOLI pepstats swissprot:METB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:METB_ECOLI pepwheel swissprot:METB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:METB_ECOLI pepwindow swissprot:METB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:METB_ECOLI sigcleave swissprot:METB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:METB_ECOLI ## Database ID URL or Descriptions # AltName AMO_ECOLI 2-phenylethylamine oxidase # AltName AMO_ECOLI Copper amine oxidase # AltName AMO_ECOLI Tyramine oxidase # BRENDA 1.4.3.21 2026 # BioGrid 4260177 10 # CATALYTIC ACTIVITY 2-phenylethylamine + H(2)O + O(2) = phenylacetaldehyde + NH(3) + H(2)O(2). {ECO:0000269|PubMed 10576737}. # CATALYTIC ACTIVITY AMO_ECOLI RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2). {ECO 0000269|PubMed 10387067, ECO 0000269|PubMed 10576737, ECO 0000269|PubMed 9048544}. # CAUTION When highly overexpressed there can be substoichiometric amounts of TPQ in the enzyme; this may be due to imperfect conversion of tyrosine to TPQ (see PubMed:8647101). {ECO 0000305}. # COFACTOR AMO_ECOLI Name=Ca(2+); Xref=ChEBI CHEBI 29108; Evidence={ECO 0000269|PubMed 10387067, ECO 0000269|PubMed 10576737, ECO 0000269|PubMed 9048544}; Note=Binds 2 calcium ions per subunit. {ECO 0000269|PubMed 10387067, ECO 0000269|PubMed 10576737, ECO 0000269|PubMed 9048544}; # COFACTOR AMO_ECOLI Name=Cu cation; Xref=ChEBI CHEBI 23378; Evidence={ECO 0000269|PubMed 10387067, ECO 0000269|PubMed 10576737, ECO 0000269|PubMed 9048544}; Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000250|UniProtKB P12807}; Note=Binds 1 copper ion per subunit. Can also use zinc ion as cofactor (By similarity). {ECO 0000250|UniProtKB P12807, ECO 0000269|PubMed 10387067, ECO 0000269|PubMed 10576737, ECO 0000269|PubMed 9048544}; # COFACTOR AMO_ECOLI Name=L-topaquinone; Xref=ChEBI CHEBI 79027; Evidence={ECO 0000269|PubMed 10387067}; Note=Contains 1 topaquinone per subunit. {ECO 0000269|PubMed 10387067}; # COFACTOR AMO_ECOLI Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000250|UniProtKB Q43077}; Note=Binds 1 Mn(2+) ion per subunit. {ECO 0000250|UniProtKB Q43077}; # ENZYME REGULATION Inhibited by 2-hydrazinopyridine. {ECO:0000269|PubMed 9048544}. # EcoGene EG13140 tynA # FUNCTION AMO_ECOLI The enzyme prefers aromatic over aliphatic amines. # GO_component GO:0042597 periplasmic space; IDA:EcoCyc. # GO_function AMO_ECOLI GO 0052593 tryptamine oxygen oxidoreductase (deaminating) activity; IEA UniProtKB-EC. # GO_function AMO_ECOLI GO 0052594 aminoacetone oxygen oxidoreductase(deaminating) activity; IEA UniProtKB-EC. # GO_function AMO_ECOLI GO 0052596 phenethylamine oxygen oxidoreductase (deaminating) activity; IEA UniProtKB-EC. # GO_function GO:0005507 copper ion binding; IDA:EcoCyc. # GO_function GO:0005509 calcium ion binding; IDA:EcoCyc. # GO_function GO:0008131 primary amine oxidase activity; IDA:EcoCyc. # GO_function GO:0048038 quinone binding; IDA:EcoCyc. # GO_function GO:0052595 aliphatic-amine oxidase activity; IEA:UniProtKB-EC. # GO_process GO:0006559 L-phenylalanine catabolic process; IEA:UniProtKB-UniPathway. # GO_process GO:0019607 phenylethylamine catabolic process; IDA:EcoCyc. # GO_process GO:0055114 oxidation-reduction process; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 2.70.98.20 -; 1. # Gene3D 3.30.457.10 -; 1. # IntAct P46883 6 # InterPro IPR000269 Cu_amine_oxidase # InterPro IPR012854 Cu_amine_oxidase-like_N # InterPro IPR015798 Cu_amine_oxidase_C # InterPro IPR015800 Cu_amine_oxidase_N2 # InterPro IPR015802 Cu_amine_oxidase_N3 # InterPro IPR016182 Cu_amine_oxidase_N-reg # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00260 Glycine, serine and threonine metabolism # KEGG_Pathway ko00350 Tyrosine metabolism # KEGG_Pathway ko00360 Phenylalanine metabolism # KEGG_Pathway ko00410 beta-Alanine metabolism # KEGG_Pathway ko00950 Isoquinoline alkaloid biosynthesis # KEGG_Pathway ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis # Organism AMO_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10638 PTHR10638 # PATHWAY Amino-acid degradation; L-phenylalanine degradation; phenylacetate from L-phenylalanine step 2/3. # PATRIC 32118058 VBIEscCol129921_1449 # PDB 1D6U X-ray; 2.40 A; A/B=31-757 # PDB 1D6Y X-ray; 2.40 A; A/B=31-757 # PDB 1D6Z X-ray; 2.10 A; A/B=31-757 # PDB 1DYU X-ray; 2.04 A; A/B=31-757 # PDB 1JRQ X-ray; 2.15 A; A/B=31-757 # PDB 1LVN X-ray; 2.40 A; A/B=31-757 # PDB 1OAC X-ray; 2.00 A; A/B=31-757 # PDB 1QAF X-ray; 2.20 A; A/B=36-756 # PDB 1QAK X-ray; 2.00 A; A/B=36-757 # PDB 1QAL X-ray; 2.20 A; A/B=36-756 # PDB 1SPU X-ray; 2.00 A; A/B=31-757 # PDB 2W0Q X-ray; 2.48 A; A/B=31-757 # PDB 2WGQ X-ray; 2.50 A; A/B=31-757 # PDB 2WO0 X-ray; 2.60 A; A/B=31-757 # PDB 2WOF X-ray; 2.25 A; A/B=31-757 # PDB 2WOH X-ray; 2.70 A; A/B=31-757 # PIR E64889 E64889 # PROSITE PS01164 COPPER_AMINE_OXID_1 # PROSITE PS01165 COPPER_AMINE_OXID_2 # PTM AMO_ECOLI Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. {ECO 0000269|PubMed 10387067}. # Pfam PF01179 Cu_amine_oxid # Pfam PF02727 Cu_amine_oxidN2 # Pfam PF02728 Cu_amine_oxidN3 # Pfam PF07833 Cu_amine_oxidN1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AMO_ECOLI Primary amine oxidase # RefSeq NP_415904 NC_000913.3 # RefSeq WP_000535469 NZ_LN832404.1 # SIMILARITY Belongs to the copper/topaquinone oxidase family. {ECO 0000305}. # SUBCELLULAR LOCATION AMO_ECOLI Periplasm. # SUBUNIT AMO_ECOLI Homodimer. {ECO 0000269|PubMed 10387067, ECO 0000269|PubMed 10576737, ECO 0000269|PubMed 9048544}. # SUPFAM SSF49998 SSF49998 # SUPFAM SSF54416 SSF54416; 2 # SUPFAM SSF55383 SSF55383 # UniPathway UPA00139 UER00723 # eggNOG COG3733 LUCA # eggNOG ENOG4105F11 Bacteria BLAST swissprot:AMO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AMO_ECOLI BioCyc ECOL316407:JW1381-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1381-MONOMER BioCyc EcoCyc:AMINEOXID-MONOMER http://biocyc.org/getid?id=EcoCyc:AMINEOXID-MONOMER BioCyc MetaCyc:AMINEOXID-MONOMER http://biocyc.org/getid?id=MetaCyc:AMINEOXID-MONOMER COG COG3733 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3733 DIP DIP-11057N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11057N DOI 10.1016/S0014-5793(97)00228-7 http://dx.doi.org/10.1016/S0014-5793(97)00228-7 DOI 10.1016/S0969-2126(01)00253-2 http://dx.doi.org/10.1016/S0969-2126(01)00253-2 DOI 10.1021/bi962205j http://dx.doi.org/10.1021/bi962205j DOI 10.1021/bi9900469 http://dx.doi.org/10.1021/bi9900469 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.273.40.25974 http://dx.doi.org/10.1074/jbc.273.40.25974 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1099/00221287-143-2-513 http://dx.doi.org/10.1099/00221287-143-2-513 DOI 10.1111/j.1432-1033.1996.0584p.x http://dx.doi.org/10.1111/j.1432-1033.1996.0584p.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1126/science.286.5445.1724 http://dx.doi.org/10.1126/science.286.5445.1724 EC_number EC:1.4.3.21 {ECO:0000269|PubMed:10387067, ECO:0000269|PubMed:10576737, ECO:0000269|PubMed:9048544} http://www.genome.jp/dbget-bin/www_bget?EC:1.4.3.21 {ECO:0000269|PubMed:10387067, ECO:0000269|PubMed:10576737, ECO:0000269|PubMed:9048544} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D23670 http://www.ebi.ac.uk/ena/data/view/D23670 EMBL L47571 http://www.ebi.ac.uk/ena/data/view/L47571 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X97452 http://www.ebi.ac.uk/ena/data/view/X97452 EMBL X97453 http://www.ebi.ac.uk/ena/data/view/X97453 ENZYME 1.4.3.21 {ECO:0000269|PubMed:10387067, ECO:0000269|PubMed:10576737, ECO:0000269|PubMed:9048544} http://enzyme.expasy.org/EC/1.4.3.21 {ECO:0000269|PubMed:10387067, ECO:0000269|PubMed:10576737, ECO:0000269|PubMed:9048544} EchoBASE EB2934 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2934 EcoGene EG13140 http://www.ecogene.org/geneInfo.php?eg_id=EG13140 EnsemblBacteria AAC74468 http://www.ensemblgenomes.org/id/AAC74468 EnsemblBacteria AAC74468 http://www.ensemblgenomes.org/id/AAC74468 EnsemblBacteria BAA14996 http://www.ensemblgenomes.org/id/BAA14996 EnsemblBacteria BAA14996 http://www.ensemblgenomes.org/id/BAA14996 EnsemblBacteria BAA14996 http://www.ensemblgenomes.org/id/BAA14996 EnsemblBacteria b1386 http://www.ensemblgenomes.org/id/b1386 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0005507 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005507 GO_function GO:0005509 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509 GO_function GO:0008131 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008131 GO_function GO:0048038 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048038 GO_function GO:0052593 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052593 GO_function GO:0052594 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052594 GO_function GO:0052595 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052595 GO_function GO:0052596 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052596 GO_process GO:0006559 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006559 GO_process GO:0019607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019607 GO_process GO:0055114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 2.70.98.20 http://www.cathdb.info/version/latest/superfamily/2.70.98.20 Gene3D 3.30.457.10 http://www.cathdb.info/version/latest/superfamily/3.30.457.10 GeneID 945939 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945939 HOGENOM HOG000250947 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000250947&db=HOGENOM6 InParanoid P46883 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P46883 IntAct P46883 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P46883* IntEnz 1.4.3.21 {ECO:0000269|PubMed:10387067, ECO:0000269|PubMed:10576737, ECO:0000269|PubMed:9048544} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.4.3.21 {ECO:0000269|PubMed:10387067, ECO:0000269|PubMed:10576737, ECO:0000269|PubMed:9048544} InterPro IPR000269 http://www.ebi.ac.uk/interpro/entry/IPR000269 InterPro IPR012854 http://www.ebi.ac.uk/interpro/entry/IPR012854 InterPro IPR015798 http://www.ebi.ac.uk/interpro/entry/IPR015798 InterPro IPR015800 http://www.ebi.ac.uk/interpro/entry/IPR015800 InterPro IPR015802 http://www.ebi.ac.uk/interpro/entry/IPR015802 InterPro IPR016182 http://www.ebi.ac.uk/interpro/entry/IPR016182 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1381 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1381 KEGG_Gene eco:b1386 http://www.genome.jp/dbget-bin/www_bget?eco:b1386 KEGG_Orthology KO:K00276 http://www.genome.jp/dbget-bin/www_bget?KO:K00276 KEGG_Pathway ko00260 http://www.genome.jp/kegg-bin/show_pathway?ko00260 KEGG_Pathway ko00350 http://www.genome.jp/kegg-bin/show_pathway?ko00350 KEGG_Pathway ko00360 http://www.genome.jp/kegg-bin/show_pathway?ko00360 KEGG_Pathway ko00410 http://www.genome.jp/kegg-bin/show_pathway?ko00410 KEGG_Pathway ko00950 http://www.genome.jp/kegg-bin/show_pathway?ko00950 KEGG_Pathway ko00960 http://www.genome.jp/kegg-bin/show_pathway?ko00960 KEGG_Reaction rn:R02382 http://www.genome.jp/dbget-bin/www_bget?rn:R02382 KEGG_Reaction rn:R02529 http://www.genome.jp/dbget-bin/www_bget?rn:R02529 KEGG_Reaction rn:R02613 http://www.genome.jp/dbget-bin/www_bget?rn:R02613 KEGG_Reaction rn:R03139 http://www.genome.jp/dbget-bin/www_bget?rn:R03139 KEGG_Reaction rn:R04027 http://www.genome.jp/dbget-bin/www_bget?rn:R04027 KEGG_Reaction rn:R04300 http://www.genome.jp/dbget-bin/www_bget?rn:R04300 KEGG_Reaction rn:R06154 http://www.genome.jp/dbget-bin/www_bget?rn:R06154 KEGG_Reaction rn:R06740 http://www.genome.jp/dbget-bin/www_bget?rn:R06740 OMA NGKKRQV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NGKKRQV PANTHER PTHR10638 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10638 PDB 1D6U http://www.ebi.ac.uk/pdbe-srv/view/entry/1D6U PDB 1D6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/1D6Y PDB 1D6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/1D6Z PDB 1DYU http://www.ebi.ac.uk/pdbe-srv/view/entry/1DYU PDB 1JRQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1JRQ PDB 1LVN http://www.ebi.ac.uk/pdbe-srv/view/entry/1LVN PDB 1OAC http://www.ebi.ac.uk/pdbe-srv/view/entry/1OAC PDB 1QAF http://www.ebi.ac.uk/pdbe-srv/view/entry/1QAF PDB 1QAK http://www.ebi.ac.uk/pdbe-srv/view/entry/1QAK PDB 1QAL http://www.ebi.ac.uk/pdbe-srv/view/entry/1QAL PDB 1SPU http://www.ebi.ac.uk/pdbe-srv/view/entry/1SPU PDB 2W0Q http://www.ebi.ac.uk/pdbe-srv/view/entry/2W0Q PDB 2WGQ http://www.ebi.ac.uk/pdbe-srv/view/entry/2WGQ PDB 2WO0 http://www.ebi.ac.uk/pdbe-srv/view/entry/2WO0 PDB 2WOF http://www.ebi.ac.uk/pdbe-srv/view/entry/2WOF PDB 2WOH http://www.ebi.ac.uk/pdbe-srv/view/entry/2WOH PDBsum 1D6U http://www.ebi.ac.uk/pdbsum/1D6U PDBsum 1D6Y http://www.ebi.ac.uk/pdbsum/1D6Y PDBsum 1D6Z http://www.ebi.ac.uk/pdbsum/1D6Z PDBsum 1DYU http://www.ebi.ac.uk/pdbsum/1DYU PDBsum 1JRQ http://www.ebi.ac.uk/pdbsum/1JRQ PDBsum 1LVN http://www.ebi.ac.uk/pdbsum/1LVN PDBsum 1OAC http://www.ebi.ac.uk/pdbsum/1OAC PDBsum 1QAF http://www.ebi.ac.uk/pdbsum/1QAF PDBsum 1QAK http://www.ebi.ac.uk/pdbsum/1QAK PDBsum 1QAL http://www.ebi.ac.uk/pdbsum/1QAL PDBsum 1SPU http://www.ebi.ac.uk/pdbsum/1SPU PDBsum 2W0Q http://www.ebi.ac.uk/pdbsum/2W0Q PDBsum 2WGQ http://www.ebi.ac.uk/pdbsum/2WGQ PDBsum 2WO0 http://www.ebi.ac.uk/pdbsum/2WO0 PDBsum 2WOF http://www.ebi.ac.uk/pdbsum/2WOF PDBsum 2WOH http://www.ebi.ac.uk/pdbsum/2WOH PROSITE PS01164 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01164 PROSITE PS01165 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01165 PSORT swissprot:AMO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AMO_ECOLI PSORT-B swissprot:AMO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AMO_ECOLI PSORT2 swissprot:AMO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AMO_ECOLI Pfam PF01179 http://pfam.xfam.org/family/PF01179 Pfam PF02727 http://pfam.xfam.org/family/PF02727 Pfam PF02728 http://pfam.xfam.org/family/PF02728 Pfam PF07833 http://pfam.xfam.org/family/PF07833 Phobius swissprot:AMO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AMO_ECOLI PhylomeDB P46883 http://phylomedb.org/?seqid=P46883 ProteinModelPortal P46883 http://www.proteinmodelportal.org/query/uniprot/P46883 PubMed 10387067 http://www.ncbi.nlm.nih.gov/pubmed/10387067 PubMed 10576737 http://www.ncbi.nlm.nih.gov/pubmed/10576737 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8591028 http://www.ncbi.nlm.nih.gov/pubmed/8591028 PubMed 8631685 http://www.ncbi.nlm.nih.gov/pubmed/8631685 PubMed 8647101 http://www.ncbi.nlm.nih.gov/pubmed/8647101 PubMed 9043126 http://www.ncbi.nlm.nih.gov/pubmed/9043126 PubMed 9048544 http://www.ncbi.nlm.nih.gov/pubmed/9048544 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9109378 http://www.ncbi.nlm.nih.gov/pubmed/9109378 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9748275 http://www.ncbi.nlm.nih.gov/pubmed/9748275 RefSeq NP_415904 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415904 RefSeq WP_000535469 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000535469 SMR P46883 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P46883 STRING 511145.b1386 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1386&targetmode=cogs STRING COG3733 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3733&targetmode=cogs SUPFAM SSF49998 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49998 SUPFAM SSF54416 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54416 SUPFAM SSF55383 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55383 UniProtKB AMO_ECOLI http://www.uniprot.org/uniprot/AMO_ECOLI UniProtKB-AC P46883 http://www.uniprot.org/uniprot/P46883 charge swissprot:AMO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AMO_ECOLI eggNOG COG3733 http://eggnogapi.embl.de/nog_data/html/tree/COG3733 eggNOG ENOG4105F11 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F11 epestfind swissprot:AMO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AMO_ECOLI garnier swissprot:AMO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AMO_ECOLI helixturnhelix swissprot:AMO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AMO_ECOLI hmoment swissprot:AMO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AMO_ECOLI iep swissprot:AMO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AMO_ECOLI inforesidue swissprot:AMO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AMO_ECOLI octanol swissprot:AMO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AMO_ECOLI pepcoil swissprot:AMO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AMO_ECOLI pepdigest swissprot:AMO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AMO_ECOLI pepinfo swissprot:AMO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AMO_ECOLI pepnet swissprot:AMO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AMO_ECOLI pepstats swissprot:AMO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AMO_ECOLI pepwheel swissprot:AMO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AMO_ECOLI pepwindow swissprot:AMO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AMO_ECOLI sigcleave swissprot:AMO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AMO_ECOLI ## Database ID URL or Descriptions # BioGrid 4263032 156 # EcoGene EG12182 yajG # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GOslim_component GO:0005886 plasma membrane # InterPro IPR005619 Uncharacterised_YajG # InterPro IPR012640 Membr_lipoprot_lipid_attach_CS # Organism YAJG_ECOLI Escherichia coli (strain K12) # PATRIC 32116019 VBIEscCol129921_0451 # PIR B64773 B64773 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF03923 Lipoprotein_16 # Pfam PF08139 LPAM_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAJG_ECOLI Uncharacterized lipoprotein YajG # RefSeq NP_414968 NC_000913.3 # RefSeq WP_001295326 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40190.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY To H.influenzae HI_0162. {ECO 0000305}. # SUBCELLULAR LOCATION YAJG_ECOLI Cell membrane {ECO 0000305}; Lipid-anchor {ECO 0000305}. # eggNOG COG3056 LUCA # eggNOG ENOG4105IEY Bacteria BLAST swissprot:YAJG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAJG_ECOLI BioCyc ECOL316407:JW0424-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0424-MONOMER BioCyc EcoCyc:EG12182-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12182-MONOMER COG COG3056 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3056 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1993.tb01731.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb01731.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL S67816 http://www.ebi.ac.uk/ena/data/view/S67816 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EchoBASE EB2099 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2099 EcoGene EG12182 http://www.ecogene.org/geneInfo.php?eg_id=EG12182 EnsemblBacteria AAC73537 http://www.ensemblgenomes.org/id/AAC73537 EnsemblBacteria AAC73537 http://www.ensemblgenomes.org/id/AAC73537 EnsemblBacteria BAE76214 http://www.ensemblgenomes.org/id/BAE76214 EnsemblBacteria BAE76214 http://www.ensemblgenomes.org/id/BAE76214 EnsemblBacteria BAE76214 http://www.ensemblgenomes.org/id/BAE76214 EnsemblBacteria b0434 http://www.ensemblgenomes.org/id/b0434 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 945521 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945521 HOGENOM HOG000117577 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117577&db=HOGENOM6 IntAct P0ADA5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADA5* InterPro IPR005619 http://www.ebi.ac.uk/interpro/entry/IPR005619 InterPro IPR012640 http://www.ebi.ac.uk/interpro/entry/IPR012640 KEGG_Gene ecj:JW0424 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0424 KEGG_Gene eco:b0434 http://www.genome.jp/dbget-bin/www_bget?eco:b0434 KEGG_Orthology KO:K07286 http://www.genome.jp/dbget-bin/www_bget?KO:K07286 OMA MTSRGYM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MTSRGYM PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YAJG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAJG_ECOLI PSORT-B swissprot:YAJG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAJG_ECOLI PSORT2 swissprot:YAJG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAJG_ECOLI Pfam PF03923 http://pfam.xfam.org/family/PF03923 Pfam PF08139 http://pfam.xfam.org/family/PF08139 Phobius swissprot:YAJG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAJG_ECOLI ProteinModelPortal P0ADA5 http://www.proteinmodelportal.org/query/uniprot/P0ADA5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8231804 http://www.ncbi.nlm.nih.gov/pubmed/8231804 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414968 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414968 RefSeq WP_001295326 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295326 SMR P0ADA5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADA5 STRING 511145.b0434 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0434&targetmode=cogs STRING COG3056 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3056&targetmode=cogs UniProtKB YAJG_ECOLI http://www.uniprot.org/uniprot/YAJG_ECOLI UniProtKB-AC P0ADA5 http://www.uniprot.org/uniprot/P0ADA5 charge swissprot:YAJG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAJG_ECOLI eggNOG COG3056 http://eggnogapi.embl.de/nog_data/html/tree/COG3056 eggNOG ENOG4105IEY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105IEY epestfind swissprot:YAJG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAJG_ECOLI garnier swissprot:YAJG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAJG_ECOLI helixturnhelix swissprot:YAJG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAJG_ECOLI hmoment swissprot:YAJG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAJG_ECOLI iep swissprot:YAJG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAJG_ECOLI inforesidue swissprot:YAJG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAJG_ECOLI octanol swissprot:YAJG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAJG_ECOLI pepcoil swissprot:YAJG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAJG_ECOLI pepdigest swissprot:YAJG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAJG_ECOLI pepinfo swissprot:YAJG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAJG_ECOLI pepnet swissprot:YAJG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAJG_ECOLI pepstats swissprot:YAJG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAJG_ECOLI pepwheel swissprot:YAJG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAJG_ECOLI pepwindow swissprot:YAJG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAJG_ECOLI sigcleave swissprot:YAJG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAJG_ECOLI ## Database ID URL or Descriptions # AltName FSAA_ECOLI Fructose-6-phosphate aldolase A # BIOPHYSICOCHEMICAL PROPERTIES FSAA_ECOLI Kinetic parameters KM=9 mM for D-fructose 6-phosphate (at 30 degrees Celsius and pH 8.5) (PubMed 11120740 and PubMed 19554584) {ECO 0000269|PubMed 11120740, ECO 0000269|PubMed 17985886, ECO 0000269|PubMed 19554584}; KM=35 mM for dihydroxyacetone (at 30 degrees Celsius and pH 8.5) {ECO 0000269|PubMed 11120740, ECO 0000269|PubMed 17985886, ECO 0000269|PubMed 19554584}; KM=0.8 mM for glyceraldehyde 3-phosphate (at 30 degrees Celsius and pH 8.5) {ECO 0000269|PubMed 11120740, ECO 0000269|PubMed 17985886, ECO 0000269|PubMed 19554584}; KM=40 mM for dihydroxyacetone (at 25 degrees Celsius and pH 8.5) {ECO 0000269|PubMed 11120740, ECO 0000269|PubMed 17985886, ECO 0000269|PubMed 19554584}; KM=11 mM for hydroxyacetone (at 25 degrees Celsius and pH 8.5) {ECO 0000269|PubMed 11120740, ECO 0000269|PubMed 17985886, ECO 0000269|PubMed 19554584}; KM=32 mM for 1-hydroxy-butan-2-one (at 25 degrees Celsius and pH 8.5) {ECO 0000269|PubMed 11120740, ECO 0000269|PubMed 17985886, ECO 0000269|PubMed 19554584}; KM=32 mM for dihydroxyacetone {ECO 0000269|PubMed 11120740, ECO 0000269|PubMed 17985886, ECO 0000269|PubMed 19554584}; KM=17.4 mM for hydroxyacetone {ECO 0000269|PubMed 11120740, ECO 0000269|PubMed 17985886, ECO 0000269|PubMed 19554584}; KM=0.197 mM for glycolaldehyde (as donor substrate in the self- aldol addition of glycolaldehyde) {ECO 0000269|PubMed 11120740, ECO 0000269|PubMed 17985886, ECO 0000269|PubMed 19554584}; KM=62.8 mM for glycolaldehyde (as acceptor substrate in the self-aldol addition of glycolaldehyde) {ECO 0000269|PubMed 11120740, ECO 0000269|PubMed 17985886, ECO 0000269|PubMed 19554584}; KM=0.286 mM for D-threose {ECO 0000269|PubMed 11120740, ECO 0000269|PubMed 17985886, ECO 0000269|PubMed 19554584}; KM=0.561 mM for D-arabinose-5-P {ECO 0000269|PubMed 11120740, ECO 0000269|PubMed 17985886, ECO 0000269|PubMed 19554584}; Vmax=45 umol/min/mg enzyme for the aldolization reaction leading to D-fructose 6-phosphate (at 30 degrees Celsius and pH 8.5) {ECO 0000269|PubMed 11120740, ECO 0000269|PubMed 17985886, ECO 0000269|PubMed 19554584}; Vmax=7 umol/min/mg enzyme for D-fructose 6-phosphate cleavage (at 30 degrees Celsius and pH 8.5) {ECO 0000269|PubMed 11120740, ECO 0000269|PubMed 17985886, ECO 0000269|PubMed 19554584}; Vmax=1.46 umol/min/mg enzyme for the aldol reaction with DHA and D,L-glyceraldehyde 3-phosphate as substrates {ECO 0000269|PubMed 11120740, ECO 0000269|PubMed 17985886, ECO 0000269|PubMed 19554584}; Vmax=33.7 umol/min/mg enzyme for the aldol reaction with HA and D,L-glyceraldehyde 3-phosphate as substrates {ECO 0000269|PubMed 11120740, ECO 0000269|PubMed 17985886, ECO 0000269|PubMed 19554584}; Vmax=0.22 umol/min/mg enzyme for the self-aldol addition of glycolaldehyde {ECO 0000269|PubMed 11120740, ECO 0000269|PubMed 17985886, ECO 0000269|PubMed 19554584}; Vmax=0.34 umol/min/mg enzyme for D-fructose 6-phosphate cleavage {ECO 0000269|PubMed 11120740, ECO 0000269|PubMed 17985886, ECO 0000269|PubMed 19554584}; Vmax=0.160 umol/min/mg enzyme for D-arabinose-5-P cleavage {ECO 0000269|PubMed 11120740, ECO 0000269|PubMed 17985886, ECO 0000269|PubMed 19554584}; Note=kcat is 1.31 sec(-1), 0.82 sec(-1) and 0.63 sec(-1) using glyceraldehyde 3-phosphate as acceptor substrate, and dihydroxyacetone, hydroxyacetone or 1-hydroxy-butan-2-one as donor substrate, respectively (at 25 degrees Celsius and pH 8.5). {ECO 0000269|PubMed 17985886}; pH dependence Optimum pH is about 8.5. Active from pH 6 to 12. {ECO 0000269|PubMed 11120740}; Temperature dependence Displays a broad temperature optimum and is active in the range from 20 to 75 degrees Celsius. Although no significant loss of activity is detected after 600 hours of incubation at 45 degrees Celsius (at pH 8.0), the respective half-lives of the enzyme are 200 hours at 55 degrees Celsius, 30 hours at 65 degrees Celsius, and 16 hours at 75 degrees Celsius. {ECO 0000269|PubMed 11120740}; # BIOTECHNOLOGY FSAA_ECOLI Is an interesting tool in chemoenzymatic synthesis for the construction of chiral complex polyhydroxylated sugar-type structures. The use of hydroxyacetone (acetol) as a donor compound allows access to various 1-deoxysugars. Can also be used for the synthesis of a broad range of iminocyclitols, that are potent glycosidase and glycosyltransferase inhibitors, from dihydroxyacetone, hydroxyacetone or 1-hydroxy-butan-2-one as donor substrate, and a range of acceptor substrates. {ECO 0000269|PubMed 17985886, ECO 0000269|PubMed 19554584, ECO 0000269|Ref.6}. # BioGrid 4263503 2 # CATALYTIC ACTIVITY FSAA_ECOLI D-fructose 6-phosphate = glycerone + D- glyceraldehyde 3-phosphate. {ECO 0000269|PubMed 11120740, ECO 0000269|PubMed 17985886, ECO 0000269|PubMed 19554584, ECO 0000269|Ref.6}. # CDD cd00956 Transaldolase_FSA # ENZYME REGULATION Inhibited by glycerol, inorganic phosphate and arabinose 5-phosphate. {ECO:0000269|PubMed 11120740}. # EcoGene EG13471 fsaA # FUNCTION FSAA_ECOLI Catalyzes the reversible formation of fructose 6- phosphate from dihydroxyacetone (DHA) and D-glyceraldehyde 3- phosphate via an aldolization reaction. Can utilize several aldehydes as acceptor compounds in vitro, and hydroxyacetone (HA) or 1-hydroxy-butan-2-one as alternative donor substrate. Is also able to catalyze the direct stereoselective self-aldol addition of glycolaldehyde to furnish D-(-)-threose, and cross-aldol reactions of glycolaldehyde to other aldehyde acceptors. Is not able to cleave fructose, fructose 1-phosphate, glucose 6-phosphate, sedoheptulose 1,7-bisphosphate, xylulose 5-phosphate, ribulose 5- phosphate, and fructose 1,6-bisphosphate; cannot use dihydroxyacetone phosphate as donor compound nor D-glyceraldehyde as acceptor. Does not display transaldolase activity. {ECO 0000269|PubMed 11120740, ECO 0000269|PubMed 17985886, ECO 0000269|PubMed 19554584, ECO 0000269|Ref.6}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0097023 fructose 6-phosphate aldolase activity; IDA:EcoCyc. # GO_process GO:0006000 fructose metabolic process; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.70 -; 1. # HAMAP MF_00496 F6P_aldolase # InterPro IPR001585 TAL/FSA # InterPro IPR004731 Transaldolase_3B/F6P_aldolase # InterPro IPR013785 Aldolase_TIM # InterPro IPR018225 Transaldolase_AS # InterPro IPR023001 F6P_aldolase # InterPro IPR033919 TSA/FSA_arc/bac # KEGG_Brite ko01000 Enzymes # MASS SPECTROMETRY Mass=22998; Method=Electrospray; Range=1-220; Evidence={ECO:0000269|PubMed 11120740}; # MISCELLANEOUS Is not inhibited by EDTA which points to a metal- independent mode of action. {ECO:0000305|PubMed 11120740}. # Organism FSAA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10683 PTHR10683 # PATRIC 32116853 VBIEscCol129921_0852 # PDB 1L6W X-ray; 1.93 A; A/B/C/D/E/F/G/H/I/J=1-220 # PDB 4RXF X-ray; 2.40 A; A/B/C/D/E/F/G/H/I/J=2-220 # PDB 4RXG X-ray; 2.15 A; A/B/C/D/E/F/G/H/I/J=1-220 # PDB 4RZ4 X-ray; 1.75 A; A/B/C/D/E/F/G/H/I/J=2-220 # PDB 4S1F X-ray; 2.24 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T=2-220 # PIR A64820 A64820 # PROSITE PS00958 TRANSALDOLASE_2 # PROSITE PS01054 TRANSALDOLASE_1 # Pfam PF00923 TAL_FSA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FSAA_ECOLI Fructose-6-phosphate aldolase 1 # RefSeq NP_415346 NC_000913.3 # RefSeq WP_001336208 NZ_LN832404.1 # SIMILARITY Belongs to the transaldolase family. Type 3A subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION FSAA_ECOLI Cytoplasm. # SUBUNIT FSAA_ECOLI Homodecamer. Five subunits are arranged as a pentamer, and two ring-like pentamers pack like a donut to form the decamer. {ECO 0000269|PubMed 11120740, ECO 0000269|PubMed 12051943}. # TIGRFAMs TIGR00875 fsa_talC_mipB # eggNOG COG0176 LUCA # eggNOG ENOG4107T9Z Bacteria BLAST swissprot:FSAA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FSAA_ECOLI BioCyc ECOL316407:JW5109-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5109-MONOMER BioCyc EcoCyc:G6428-MONOMER http://biocyc.org/getid?id=EcoCyc:G6428-MONOMER BioCyc MetaCyc:G6428-MONOMER http://biocyc.org/getid?id=MetaCyc:G6428-MONOMER COG COG0176 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0176 DIP DIP-10218N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10218N DOI 10.1002/anie.200902065 http://dx.doi.org/10.1002/anie.200902065 DOI 10.1016/S0022-2836(02)00258-9 http://dx.doi.org/10.1016/S0022-2836(02)00258-9 DOI 10.1021/ja073911i http://dx.doi.org/10.1021/ja073911i DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M008061200 http://dx.doi.org/10.1074/jbc.M008061200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.1.2.- http://www.genome.jp/dbget-bin/www_bget?EC:4.1.2.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D88188 http://www.ebi.ac.uk/ena/data/view/D88188 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 4.1.2.- http://enzyme.expasy.org/EC/4.1.2.- EchoBASE EB3244 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3244 EcoGene EG13471 http://www.ecogene.org/geneInfo.php?eg_id=EG13471 EnsemblBacteria AAC73912 http://www.ensemblgenomes.org/id/AAC73912 EnsemblBacteria AAC73912 http://www.ensemblgenomes.org/id/AAC73912 EnsemblBacteria BAA35513 http://www.ensemblgenomes.org/id/BAA35513 EnsemblBacteria BAA35513 http://www.ensemblgenomes.org/id/BAA35513 EnsemblBacteria BAA35513 http://www.ensemblgenomes.org/id/BAA35513 EnsemblBacteria b0825 http://www.ensemblgenomes.org/id/b0825 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0097023 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097023 GO_process GO:0006000 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006000 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 945449 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945449 HAMAP MF_00496 http://hamap.expasy.org/unirule/MF_00496 HOGENOM HOG000226075 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000226075&db=HOGENOM6 InParanoid P78055 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P78055 IntAct P78055 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P78055* IntEnz 4.1.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.2 InterPro IPR001585 http://www.ebi.ac.uk/interpro/entry/IPR001585 InterPro IPR004731 http://www.ebi.ac.uk/interpro/entry/IPR004731 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR018225 http://www.ebi.ac.uk/interpro/entry/IPR018225 InterPro IPR023001 http://www.ebi.ac.uk/interpro/entry/IPR023001 InterPro IPR033919 http://www.ebi.ac.uk/interpro/entry/IPR033919 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5109 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5109 KEGG_Gene eco:b0825 http://www.genome.jp/dbget-bin/www_bget?eco:b0825 KEGG_Orthology KO:K08313 http://www.genome.jp/dbget-bin/www_bget?KO:K08313 OMA IHVQVVA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IHVQVVA PANTHER PTHR10683 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10683 PDB 1L6W http://www.ebi.ac.uk/pdbe-srv/view/entry/1L6W PDB 4RXF http://www.ebi.ac.uk/pdbe-srv/view/entry/4RXF PDB 4RXG http://www.ebi.ac.uk/pdbe-srv/view/entry/4RXG PDB 4RZ4 http://www.ebi.ac.uk/pdbe-srv/view/entry/4RZ4 PDB 4S1F http://www.ebi.ac.uk/pdbe-srv/view/entry/4S1F PDBsum 1L6W http://www.ebi.ac.uk/pdbsum/1L6W PDBsum 4RXF http://www.ebi.ac.uk/pdbsum/4RXF PDBsum 4RXG http://www.ebi.ac.uk/pdbsum/4RXG PDBsum 4RZ4 http://www.ebi.ac.uk/pdbsum/4RZ4 PDBsum 4S1F http://www.ebi.ac.uk/pdbsum/4S1F PROSITE PS00958 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00958 PROSITE PS01054 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01054 PSORT swissprot:FSAA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FSAA_ECOLI PSORT-B swissprot:FSAA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FSAA_ECOLI PSORT2 swissprot:FSAA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FSAA_ECOLI Pfam PF00923 http://pfam.xfam.org/family/PF00923 Phobius swissprot:FSAA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FSAA_ECOLI PhylomeDB P78055 http://phylomedb.org/?seqid=P78055 ProteinModelPortal P78055 http://www.proteinmodelportal.org/query/uniprot/P78055 PubMed 11120740 http://www.ncbi.nlm.nih.gov/pubmed/11120740 PubMed 12051943 http://www.ncbi.nlm.nih.gov/pubmed/12051943 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17985886 http://www.ncbi.nlm.nih.gov/pubmed/17985886 PubMed 19554584 http://www.ncbi.nlm.nih.gov/pubmed/19554584 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415346 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415346 RefSeq WP_001336208 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001336208 SMR P78055 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P78055 STRING 511145.b0825 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0825&targetmode=cogs STRING COG0176 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0176&targetmode=cogs TIGRFAMs TIGR00875 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00875 UniProtKB FSAA_ECOLI http://www.uniprot.org/uniprot/FSAA_ECOLI UniProtKB-AC P78055 http://www.uniprot.org/uniprot/P78055 charge swissprot:FSAA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FSAA_ECOLI eggNOG COG0176 http://eggnogapi.embl.de/nog_data/html/tree/COG0176 eggNOG ENOG4107T9Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107T9Z epestfind swissprot:FSAA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FSAA_ECOLI garnier swissprot:FSAA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FSAA_ECOLI helixturnhelix swissprot:FSAA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FSAA_ECOLI hmoment swissprot:FSAA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FSAA_ECOLI iep swissprot:FSAA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FSAA_ECOLI inforesidue swissprot:FSAA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FSAA_ECOLI octanol swissprot:FSAA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FSAA_ECOLI pepcoil swissprot:FSAA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FSAA_ECOLI pepdigest swissprot:FSAA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FSAA_ECOLI pepinfo swissprot:FSAA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FSAA_ECOLI pepnet swissprot:FSAA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FSAA_ECOLI pepstats swissprot:FSAA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FSAA_ECOLI pepwheel swissprot:FSAA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FSAA_ECOLI pepwindow swissprot:FSAA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FSAA_ECOLI sigcleave swissprot:FSAA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FSAA_ECOLI ## Database ID URL or Descriptions # AltName GSPJ_ECOLI Putative general secretion pathway protein J # BioGrid 4261132 283 # EcoGene EG12893 gspJ # FUNCTION GSPJ_ECOLI Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. {ECO 0000305}. # GO_process GO:0015628 protein secretion by the type II secretion system; IBA:GO_Central. # GOslim_process GO:0055085 transmembrane transport # INDUCTION Silenced by the DNA-binding protein H-NS under standard growth conditions. {ECO:0000269|PubMed 11118204}. # InterPro IPR012902 N_methyl_site # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02044 M00331 Type II general secretion system # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko03070 Bacterial secretion system # MISCELLANEOUS GSPJ_ECOLI Part of a cryptic operon that encodes proteins involved in type II secretion machinery in other organisms, but is not expressed in strain K12. # Organism GSPJ_ECOLI Escherichia coli (strain K12) # PATRIC 32122094 VBIEscCol129921_3424 # PIR F65126 F65126 # PROSITE PS00409 PROKAR_NTER_METHYL # Pfam PF07963 N_methyl # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GSPJ_ECOLI Putative type II secretion system protein J # RefSeq NP_417790 NC_000913.3 # RefSeq WP_000610634 NZ_LN832404.1 # SIMILARITY Belongs to the GSP J family. {ECO 0000305}. # TIGRFAMs TIGR02532 IV_pilin_GFxxxE # eggNOG COG4795 LUCA BLAST swissprot:GSPJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GSPJ_ECOLI BioCyc ECOL316407:JW3293-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3293-MONOMER BioCyc EcoCyc:G7709-MONOMER http://biocyc.org/getid?id=EcoCyc:G7709-MONOMER BioCyc MetaCyc:G7709-MONOMER http://biocyc.org/getid?id=MetaCyc:G7709-MONOMER COG COG2165 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2165 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/emboj/19.24.6697 http://dx.doi.org/10.1093/emboj/19.24.6697 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2730 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2730 EcoGene EG12893 http://www.ecogene.org/geneInfo.php?eg_id=EG12893 EnsemblBacteria AAC76356 http://www.ensemblgenomes.org/id/AAC76356 EnsemblBacteria AAC76356 http://www.ensemblgenomes.org/id/AAC76356 EnsemblBacteria BAE77960 http://www.ensemblgenomes.org/id/BAE77960 EnsemblBacteria BAE77960 http://www.ensemblgenomes.org/id/BAE77960 EnsemblBacteria BAE77960 http://www.ensemblgenomes.org/id/BAE77960 EnsemblBacteria b3331 http://www.ensemblgenomes.org/id/b3331 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0015628 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015628 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 947832 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947832 HOGENOM HOG000125375 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125375&db=HOGENOM6 InParanoid P45761 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45761 IntAct P45761 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45761* InterPro IPR012902 http://www.ebi.ac.uk/interpro/entry/IPR012902 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW3293 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3293 KEGG_Gene eco:b3331 http://www.genome.jp/dbget-bin/www_bget?eco:b3331 KEGG_Orthology KO:K02459 http://www.genome.jp/dbget-bin/www_bget?KO:K02459 KEGG_Pathway ko03070 http://www.genome.jp/kegg-bin/show_pathway?ko03070 OMA QLERVAW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QLERVAW PROSITE PS00409 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00409 PSORT swissprot:GSPJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GSPJ_ECOLI PSORT-B swissprot:GSPJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GSPJ_ECOLI PSORT2 swissprot:GSPJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GSPJ_ECOLI Pfam PF07963 http://pfam.xfam.org/family/PF07963 Phobius swissprot:GSPJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GSPJ_ECOLI PhylomeDB P45761 http://phylomedb.org/?seqid=P45761 ProteinModelPortal P45761 http://www.proteinmodelportal.org/query/uniprot/P45761 PubMed 11118204 http://www.ncbi.nlm.nih.gov/pubmed/11118204 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8655552 http://www.ncbi.nlm.nih.gov/pubmed/8655552 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417790 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417790 RefSeq WP_000610634 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000610634 SMR P45761 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45761 STRING 511145.b3331 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3331&targetmode=cogs STRING COG2165 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2165&targetmode=cogs TIGRFAMs TIGR02532 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02532 UniProtKB GSPJ_ECOLI http://www.uniprot.org/uniprot/GSPJ_ECOLI UniProtKB-AC P45761 http://www.uniprot.org/uniprot/P45761 charge swissprot:GSPJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GSPJ_ECOLI eggNOG COG4795 http://eggnogapi.embl.de/nog_data/html/tree/COG4795 epestfind swissprot:GSPJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GSPJ_ECOLI garnier swissprot:GSPJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GSPJ_ECOLI helixturnhelix swissprot:GSPJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GSPJ_ECOLI hmoment swissprot:GSPJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GSPJ_ECOLI iep swissprot:GSPJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GSPJ_ECOLI inforesidue swissprot:GSPJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GSPJ_ECOLI octanol swissprot:GSPJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GSPJ_ECOLI pepcoil swissprot:GSPJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GSPJ_ECOLI pepdigest swissprot:GSPJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GSPJ_ECOLI pepinfo swissprot:GSPJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GSPJ_ECOLI pepnet swissprot:GSPJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GSPJ_ECOLI pepstats swissprot:GSPJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GSPJ_ECOLI pepwheel swissprot:GSPJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GSPJ_ECOLI pepwindow swissprot:GSPJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GSPJ_ECOLI sigcleave swissprot:GSPJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GSPJ_ECOLI ## Database ID URL or Descriptions # AltName FADH_ECOLI 2,4-dienoyl coenzyme A reductase # BRENDA 1.3.1.34 2026 # BioGrid 4261984 13 # CATALYTIC ACTIVITY FADH_ECOLI Trans-2,3-didehydroacyl-CoA + NADP(+) = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH. # COFACTOR Name=FAD; Xref=ChEBI:CHEBI 57692; # DOMAIN FADH_ECOLI The N-terminus may contain the FAD-binding domain whereas the NADPH-binding domain may be located in the C-terminus. # DrugBank DB03147 Flavin adenine dinucleotide # EcoGene EG12723 fadH # FUNCTION FADH_ECOLI Catalyzes the NADP-dependent reduction of 2,4-dienoyl- CoA to yield trans-2- enoyl-CoA. # GO_component GO:0005622 intracellular; IBA:GO_Central. # GO_function GO:0003959 NADPH dehydrogenase activity; IBA:GO_Central. # GO_function GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity; IDA:EcoCyc. # GO_function GO:0010181 FMN binding; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IDA:EcoCyc. # GO_function GO:0071949 FAD binding; IDA:EcoCyc. # GO_process GO:0033543 fatty acid beta-oxidation, unsaturated, even number, reductase/isomerase pathway; IMP:EcoCyc. # GOslim_component GO:0005622 intracellular # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.70 -; 1. # Gene3D 3.50.50.60 -; 2. # IntAct P42593 10 # InterPro IPR001155 OxRdtase_FMN_N # InterPro IPR013785 Aldolase_TIM # InterPro IPR023753 FAD/NAD-binding_dom # KEGG_Brite ko01000 Enzymes # Organism FADH_ECOLI Escherichia coli (strain K12) # PATRIC 32121580 VBIEscCol129921_3176 # PDB 1PS9 X-ray; 2.20 A; A=2-672 # PIR F65096 F65096 # Pfam PF00724 Oxidored_FMN # Pfam PF07992 Pyr_redox_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FADH_ECOLI 2,4-dienoyl-CoA reductase [NADPH] # RefSeq NP_417552 NC_000913.3 # RefSeq WP_000121433 NZ_LN832404.1 # SUBUNIT FADH_ECOLI Monomer. # SUPFAM SSF51905 SSF51905 # eggNOG COG0446 LUCA # eggNOG COG1902 LUCA # eggNOG ENOG4105CCY Bacteria BLAST swissprot:FADH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FADH_ECOLI BioCyc ECOL316407:JW3052-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3052-MONOMER BioCyc EcoCyc:DIENOYLCOAREDUCT-MONOMER http://biocyc.org/getid?id=EcoCyc:DIENOYLCOAREDUCT-MONOMER BioCyc MetaCyc:DIENOYLCOAREDUCT-MONOMER http://biocyc.org/getid?id=MetaCyc:DIENOYLCOAREDUCT-MONOMER COG COG0446 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0446 COG COG1902 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1902 DIP DIP-9562N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9562N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1432-1033.1997.00516.x http://dx.doi.org/10.1111/j.1432-1033.1997.00516.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB03147 http://www.drugbank.ca/drugs/DB03147 EC_number EC:1.3.1.34 http://www.genome.jp/dbget-bin/www_bget?EC:1.3.1.34 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL U93405 http://www.ebi.ac.uk/ena/data/view/U93405 ENZYME 1.3.1.34 http://enzyme.expasy.org/EC/1.3.1.34 EchoBASE EB2582 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2582 EcoGene EG12723 http://www.ecogene.org/geneInfo.php?eg_id=EG12723 EnsemblBacteria AAC76116 http://www.ensemblgenomes.org/id/AAC76116 EnsemblBacteria AAC76116 http://www.ensemblgenomes.org/id/AAC76116 EnsemblBacteria BAE77131 http://www.ensemblgenomes.org/id/BAE77131 EnsemblBacteria BAE77131 http://www.ensemblgenomes.org/id/BAE77131 EnsemblBacteria BAE77131 http://www.ensemblgenomes.org/id/BAE77131 EnsemblBacteria b3081 http://www.ensemblgenomes.org/id/b3081 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_function GO:0003959 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003959 GO_function GO:0008670 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008670 GO_function GO:0010181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010181 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_function GO:0071949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071949 GO_process GO:0033543 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033543 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 GeneID 947594 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947594 HOGENOM HOG000237760 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000237760&db=HOGENOM6 InParanoid P42593 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P42593 IntAct P42593 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P42593* IntEnz 1.3.1.34 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.3.1.34 InterPro IPR001155 http://www.ebi.ac.uk/interpro/entry/IPR001155 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3052 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3052 KEGG_Gene eco:b3081 http://www.genome.jp/dbget-bin/www_bget?eco:b3081 KEGG_Orthology KO:K00219 http://www.genome.jp/dbget-bin/www_bget?KO:K00219 OMA SEVIRQN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SEVIRQN PDB 1PS9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1PS9 PDBsum 1PS9 http://www.ebi.ac.uk/pdbsum/1PS9 PSORT swissprot:FADH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FADH_ECOLI PSORT-B swissprot:FADH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FADH_ECOLI PSORT2 swissprot:FADH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FADH_ECOLI Pfam PF00724 http://pfam.xfam.org/family/PF00724 Pfam PF07992 http://pfam.xfam.org/family/PF07992 Phobius swissprot:FADH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FADH_ECOLI PhylomeDB P42593 http://phylomedb.org/?seqid=P42593 ProteinModelPortal P42593 http://www.proteinmodelportal.org/query/uniprot/P42593 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9346310 http://www.ncbi.nlm.nih.gov/pubmed/9346310 RefSeq NP_417552 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417552 RefSeq WP_000121433 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000121433 SMR P42593 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P42593 STRING 511145.b3081 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3081&targetmode=cogs STRING COG0446 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0446&targetmode=cogs STRING COG1902 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1902&targetmode=cogs SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 UniProtKB FADH_ECOLI http://www.uniprot.org/uniprot/FADH_ECOLI UniProtKB-AC P42593 http://www.uniprot.org/uniprot/P42593 charge swissprot:FADH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FADH_ECOLI eggNOG COG0446 http://eggnogapi.embl.de/nog_data/html/tree/COG0446 eggNOG COG1902 http://eggnogapi.embl.de/nog_data/html/tree/COG1902 eggNOG ENOG4105CCY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CCY epestfind swissprot:FADH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FADH_ECOLI garnier swissprot:FADH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FADH_ECOLI helixturnhelix swissprot:FADH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FADH_ECOLI hmoment swissprot:FADH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FADH_ECOLI iep swissprot:FADH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FADH_ECOLI inforesidue swissprot:FADH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FADH_ECOLI octanol swissprot:FADH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FADH_ECOLI pepcoil swissprot:FADH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FADH_ECOLI pepdigest swissprot:FADH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FADH_ECOLI pepinfo swissprot:FADH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FADH_ECOLI pepnet swissprot:FADH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FADH_ECOLI pepstats swissprot:FADH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FADH_ECOLI pepwheel swissprot:FADH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FADH_ECOLI pepwindow swissprot:FADH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FADH_ECOLI sigcleave swissprot:FADH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FADH_ECOLI ## Database ID URL or Descriptions # BioGrid 4262377 13 # EcoGene EG13007 yghW # IntAct P64574 32 # InterPro IPR022574 DUF2623 # Organism YGHW_ECOLI Escherichia coli (strain K12) # PATRIC 32121412 VBIEscCol129921_3093 # PIR D65086 D65086 # Pfam PF11115 DUF2623 # ProDom PD065638 Uncharacterised_YghW # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGHW_ECOLI Uncharacterized protein YghW # RefSeq NP_417472 NC_000913.3 # RefSeq WP_001059136 NZ_LN832404.1 # eggNOG ENOG410900S Bacteria # eggNOG ENOG4111S6B LUCA BLAST swissprot:YGHW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGHW_ECOLI BioCyc ECOL316407:JW2966-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2966-MONOMER BioCyc EcoCyc:G7555-MONOMER http://biocyc.org/getid?id=EcoCyc:G7555-MONOMER DIP DIP-35982N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35982N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2829 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2829 EcoGene EG13007 http://www.ecogene.org/geneInfo.php?eg_id=EG13007 EnsemblBacteria AAC76034 http://www.ensemblgenomes.org/id/AAC76034 EnsemblBacteria AAC76034 http://www.ensemblgenomes.org/id/AAC76034 EnsemblBacteria BAE77059 http://www.ensemblgenomes.org/id/BAE77059 EnsemblBacteria BAE77059 http://www.ensemblgenomes.org/id/BAE77059 EnsemblBacteria BAE77059 http://www.ensemblgenomes.org/id/BAE77059 EnsemblBacteria b2998 http://www.ensemblgenomes.org/id/b2998 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947485 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947485 HOGENOM HOG000124991 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000124991&db=HOGENOM6 IntAct P64574 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P64574* InterPro IPR022574 http://www.ebi.ac.uk/interpro/entry/IPR022574 KEGG_Gene ecj:JW2966 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2966 KEGG_Gene eco:b2998 http://www.genome.jp/dbget-bin/www_bget?eco:b2998 OMA RYFMAGY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RYFMAGY PSORT swissprot:YGHW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGHW_ECOLI PSORT-B swissprot:YGHW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGHW_ECOLI PSORT2 swissprot:YGHW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGHW_ECOLI Pfam PF11115 http://pfam.xfam.org/family/PF11115 Phobius swissprot:YGHW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGHW_ECOLI ProteinModelPortal P64574 http://www.proteinmodelportal.org/query/uniprot/P64574 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417472 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417472 RefSeq WP_001059136 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001059136 STRING 511145.b2998 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2998&targetmode=cogs UniProtKB YGHW_ECOLI http://www.uniprot.org/uniprot/YGHW_ECOLI UniProtKB-AC P64574 http://www.uniprot.org/uniprot/P64574 charge swissprot:YGHW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGHW_ECOLI eggNOG ENOG410900S http://eggnogapi.embl.de/nog_data/html/tree/ENOG410900S eggNOG ENOG4111S6B http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111S6B epestfind swissprot:YGHW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGHW_ECOLI garnier swissprot:YGHW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGHW_ECOLI helixturnhelix swissprot:YGHW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGHW_ECOLI hmoment swissprot:YGHW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGHW_ECOLI iep swissprot:YGHW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGHW_ECOLI inforesidue swissprot:YGHW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGHW_ECOLI octanol swissprot:YGHW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGHW_ECOLI pepcoil swissprot:YGHW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGHW_ECOLI pepdigest swissprot:YGHW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGHW_ECOLI pepinfo swissprot:YGHW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGHW_ECOLI pepnet swissprot:YGHW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGHW_ECOLI pepstats swissprot:YGHW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGHW_ECOLI pepwheel swissprot:YGHW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGHW_ECOLI pepwindow swissprot:YGHW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGHW_ECOLI sigcleave swissprot:YGHW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGHW_ECOLI ## Database ID URL or Descriptions # AltName NUOM_ECOLI NADH dehydrogenase I subunit M # AltName NUOM_ECOLI NDH-1 subunit M # AltName NUOM_ECOLI NUO13 # BioGrid 4260887 40 # CATALYTIC ACTIVITY NUOM_ECOLI NADH + a quinone = NAD(+) + a quinol. # EcoGene EG11773 nuoM # FUNCTION NUOM_ECOLI NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0030964 NADH dehydrogenase complex; IDA:EcoliWiki. # GO_component GO:0045272 plasma membrane respiratory chain complex I; IDA:EcoCyc. # GO_function GO:0008137 NADH dehydrogenase (ubiquinone) activity; IEA:InterPro. # GO_function GO:0048039 ubiquinone binding; IDA:EcoCyc. # GO_process GO:0009060 aerobic respiration; IMP:EcoCyc. # GO_process GO:0015990 electron transport coupled proton transport; IMP:EcoCyc. # GO_process GO:0042773 ATP synthesis coupled electron transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0055085 transmembrane transport # InterPro IPR001750 ND/Mrp_mem # InterPro IPR003918 NADH_UbQ_OxRdtase # InterPro IPR010227 NADH_Q_OxRdtase_chainM/4 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00190 Oxidative phosphorylation # KEGG_Pathway ko00910 Nitrogen metabolism # Organism NUOM_ECOLI Escherichia coli (strain K12) # PATRIC 32119921 VBIEscCol129921_2370 # PIR C64999 C64999 # PRINTS PR01437 NUOXDRDTASE4 # Pfam PF00361 Proton_antipo_M # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NUOM_ECOLI NADH-quinone oxidoreductase subunit M # RefSeq NP_416780 NC_000913.3 # RefSeq WP_000926441 NZ_LN832404.1 # SIMILARITY Belongs to the complex I subunit 4 family. {ECO 0000305}. # SUBCELLULAR LOCATION NUOM_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT NUOM_ECOLI Composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex. # TCDB 3.D.1.1 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family # TIGRFAMs TIGR01972 NDH_I_M # eggNOG COG1008 LUCA # eggNOG ENOG4105C8S Bacteria BLAST swissprot:NUOM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NUOM_ECOLI BioCyc ECOL316407:JW2272-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2272-MONOMER BioCyc EcoCyc:NUOM-MONOMER http://biocyc.org/getid?id=EcoCyc:NUOM-MONOMER BioCyc MetaCyc:NUOM-MONOMER http://biocyc.org/getid?id=MetaCyc:NUOM-MONOMER COG COG1008 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1008 DIP DIP-59255N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-59255N DOI 10.1006/jmbi.1993.1488 http://dx.doi.org/10.1006/jmbi.1993.1488 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.6.5.11 http://www.genome.jp/dbget-bin/www_bget?EC:1.6.5.11 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19568 http://www.ebi.ac.uk/ena/data/view/L19568 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X68301 http://www.ebi.ac.uk/ena/data/view/X68301 ENZYME 1.6.5.11 http://enzyme.expasy.org/EC/1.6.5.11 EchoBASE EB1722 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1722 EcoGene EG11773 http://www.ecogene.org/geneInfo.php?eg_id=EG11773 EnsemblBacteria AAC75337 http://www.ensemblgenomes.org/id/AAC75337 EnsemblBacteria AAC75337 http://www.ensemblgenomes.org/id/AAC75337 EnsemblBacteria BAA16105 http://www.ensemblgenomes.org/id/BAA16105 EnsemblBacteria BAA16105 http://www.ensemblgenomes.org/id/BAA16105 EnsemblBacteria BAA16105 http://www.ensemblgenomes.org/id/BAA16105 EnsemblBacteria b2277 http://www.ensemblgenomes.org/id/b2277 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0030964 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030964 GO_component GO:0045272 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045272 GO_function GO:0008137 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008137 GO_function GO:0048039 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048039 GO_process GO:0009060 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009060 GO_process GO:0015990 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015990 GO_process GO:0042773 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042773 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 947731 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947731 HOGENOM HOG000100682 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000100682&db=HOGENOM6 InParanoid P0AFE8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFE8 IntEnz 1.6.5.11 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.6.5.11 InterPro IPR001750 http://www.ebi.ac.uk/interpro/entry/IPR001750 InterPro IPR003918 http://www.ebi.ac.uk/interpro/entry/IPR003918 InterPro IPR010227 http://www.ebi.ac.uk/interpro/entry/IPR010227 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2272 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2272 KEGG_Gene eco:b2277 http://www.genome.jp/dbget-bin/www_bget?eco:b2277 KEGG_Orthology KO:K00342 http://www.genome.jp/dbget-bin/www_bget?KO:K00342 KEGG_Pathway ko00190 http://www.genome.jp/kegg-bin/show_pathway?ko00190 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Reaction rn:R02166 http://www.genome.jp/dbget-bin/www_bget?rn:R02166 OMA MGGLWHR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MGGLWHR PRINTS PR01437 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01437 PSORT swissprot:NUOM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NUOM_ECOLI PSORT-B swissprot:NUOM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NUOM_ECOLI PSORT2 swissprot:NUOM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NUOM_ECOLI Pfam PF00361 http://pfam.xfam.org/family/PF00361 Phobius swissprot:NUOM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NUOM_ECOLI PhylomeDB P0AFE8 http://phylomedb.org/?seqid=P0AFE8 ProteinModelPortal P0AFE8 http://www.proteinmodelportal.org/query/uniprot/P0AFE8 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7690854 http://www.ncbi.nlm.nih.gov/pubmed/7690854 PubMed 8366049 http://www.ncbi.nlm.nih.gov/pubmed/8366049 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416780 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416780 RefSeq WP_000926441 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000926441 STRING 511145.b2277 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2277&targetmode=cogs STRING COG1008 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1008&targetmode=cogs TCDB 3.D.1.1 http://www.tcdb.org/search/result.php?tc=3.D.1.1 TIGRFAMs TIGR01972 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01972 UniProtKB NUOM_ECOLI http://www.uniprot.org/uniprot/NUOM_ECOLI UniProtKB-AC P0AFE8 http://www.uniprot.org/uniprot/P0AFE8 charge swissprot:NUOM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NUOM_ECOLI eggNOG COG1008 http://eggnogapi.embl.de/nog_data/html/tree/COG1008 eggNOG ENOG4105C8S http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C8S epestfind swissprot:NUOM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NUOM_ECOLI garnier swissprot:NUOM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NUOM_ECOLI helixturnhelix swissprot:NUOM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NUOM_ECOLI hmoment swissprot:NUOM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NUOM_ECOLI iep swissprot:NUOM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NUOM_ECOLI inforesidue swissprot:NUOM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NUOM_ECOLI octanol swissprot:NUOM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NUOM_ECOLI pepcoil swissprot:NUOM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NUOM_ECOLI pepdigest swissprot:NUOM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NUOM_ECOLI pepinfo swissprot:NUOM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NUOM_ECOLI pepnet swissprot:NUOM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NUOM_ECOLI pepstats swissprot:NUOM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NUOM_ECOLI pepwheel swissprot:NUOM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NUOM_ECOLI pepwindow swissprot:NUOM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NUOM_ECOLI sigcleave swissprot:NUOM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NUOM_ECOLI ## Database ID URL or Descriptions # AltName ACRF_ECOLI Acriflavine resistance protein F # AltName ACRF_ECOLI Protein EnvD # BioGrid 4262457 308 # EcoGene EG10267 acrF # FUNCTION ACRF_ECOLI Part of the tripartite efflux system AcrEF-TolC. Involved in the efflux of indole and organic solvents. {ECO 0000269|PubMed 10518736, ECO 0000269|PubMed 11274125}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005215 transporter activity; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # Gene3D 3.30.2090.10 -; 2. # INDUCTION Induced by LeuO, part of the acrEF operon. {ECO:0000269|PubMed 19429622}. # InterPro IPR001036 Acrflvin-R # InterPro IPR004764 HAE1 # InterPro IPR027463 AcrB_DN_DC_subdom # Organism ACRF_ECOLI Escherichia coli (strain K12) # PATRIC 32121962 VBIEscCol129921_3365 # PIR D65119 D65119 # PRINTS PR00702 ACRIFLAVINRP # Pfam PF00873 ACR_tran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ACRF_ECOLI Multidrug export protein AcrF # RefSeq NP_417732 NC_000913.3 # RefSeq WP_001273238 NZ_LN832404.1 # SIMILARITY Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. {ECO 0000305}. # SUBCELLULAR LOCATION ACRF_ECOLI Cell inner membrane {ECO 0000269|PubMed 11274125, ECO 0000269|PubMed 15919996}; Multi- pass membrane protein {ECO 0000269|PubMed 11274125, ECO 0000269|PubMed 15919996}. # SUBUNIT Part of the tripartite efflux system AcrEF-TolC, which is composed of an inner membrane transporter, AcrF, a periplasmic membrane fusion protein, AcrE, and an outer membrane component, TolC. The complex forms a large protein conduit and can translocate molecules across both the inner and outer membranes (Probable). {ECO:0000305|PubMed 11274125}. # SUPFAM SSF82714 SSF82714; 2 # TCDB 2.A.6.2 the resistance-nodulation-cell division (rnd) superfamily # TIGRFAMs TIGR00915 2A0602 # eggNOG COG0841 LUCA # eggNOG ENOG4105BZS Bacteria BLAST swissprot:ACRF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ACRF_ECOLI BioCyc ECOL316407:JW3234-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3234-MONOMER BioCyc EcoCyc:ACRF-MONOMER http://biocyc.org/getid?id=EcoCyc:ACRF-MONOMER COG COG0841 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0841 DIP DIP-9052N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9052N DOI 10.1007/BF00290673 http://dx.doi.org/10.1007/BF00290673 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1574-6968.1999.tb08748.x http://dx.doi.org/10.1111/j.1574-6968.1999.tb08748.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00108-09 http://dx.doi.org/10.1128/JB.00108-09 DOI 10.1128/JB.183.8.2646-2653.2001 http://dx.doi.org/10.1128/JB.183.8.2646-2653.2001 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M96848 http://www.ebi.ac.uk/ena/data/view/M96848 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X57948 http://www.ebi.ac.uk/ena/data/view/X57948 EchoBASE EB0263 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0263 EcoGene EG10267 http://www.ecogene.org/geneInfo.php?eg_id=EG10267 EnsemblBacteria AAC76298 http://www.ensemblgenomes.org/id/AAC76298 EnsemblBacteria AAC76298 http://www.ensemblgenomes.org/id/AAC76298 EnsemblBacteria BAE77307 http://www.ensemblgenomes.org/id/BAE77307 EnsemblBacteria BAE77307 http://www.ensemblgenomes.org/id/BAE77307 EnsemblBacteria BAE77307 http://www.ensemblgenomes.org/id/BAE77307 EnsemblBacteria b3266 http://www.ensemblgenomes.org/id/b3266 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 Gene3D 3.30.2090.10 http://www.cathdb.info/version/latest/superfamily/3.30.2090.10 GeneID 947768 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947768 HOGENOM HOG000158129 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000158129&db=HOGENOM6 InParanoid P24181 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P24181 IntAct P24181 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P24181* InterPro IPR001036 http://www.ebi.ac.uk/interpro/entry/IPR001036 InterPro IPR004764 http://www.ebi.ac.uk/interpro/entry/IPR004764 InterPro IPR027463 http://www.ebi.ac.uk/interpro/entry/IPR027463 KEGG_Gene ecj:JW3234 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3234 KEGG_Gene eco:b3266 http://www.genome.jp/dbget-bin/www_bget?eco:b3266 KEGG_Orthology KO:K03296 http://www.genome.jp/dbget-bin/www_bget?KO:K03296 MINT MINT-1267966 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1267966 OMA FFGWFNA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FFGWFNA PRINTS PR00702 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00702 PSORT swissprot:ACRF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ACRF_ECOLI PSORT-B swissprot:ACRF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ACRF_ECOLI PSORT2 swissprot:ACRF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ACRF_ECOLI Pfam PF00873 http://pfam.xfam.org/family/PF00873 Phobius swissprot:ACRF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ACRF_ECOLI PhylomeDB P24181 http://phylomedb.org/?seqid=P24181 ProteinModelPortal P24181 http://www.proteinmodelportal.org/query/uniprot/P24181 PubMed 10518736 http://www.ncbi.nlm.nih.gov/pubmed/10518736 PubMed 11274125 http://www.ncbi.nlm.nih.gov/pubmed/11274125 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1720861 http://www.ncbi.nlm.nih.gov/pubmed/1720861 PubMed 19429622 http://www.ncbi.nlm.nih.gov/pubmed/19429622 PubMed 8407802 http://www.ncbi.nlm.nih.gov/pubmed/8407802 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417732 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417732 RefSeq WP_001273238 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001273238 SMR P24181 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P24181 STRING 511145.b3266 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3266&targetmode=cogs STRING COG0841 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0841&targetmode=cogs SUPFAM SSF82714 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF82714 TCDB 2.A.6.2 http://www.tcdb.org/search/result.php?tc=2.A.6.2 TIGRFAMs TIGR00915 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00915 UniProtKB ACRF_ECOLI http://www.uniprot.org/uniprot/ACRF_ECOLI UniProtKB-AC P24181 http://www.uniprot.org/uniprot/P24181 charge swissprot:ACRF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ACRF_ECOLI eggNOG COG0841 http://eggnogapi.embl.de/nog_data/html/tree/COG0841 eggNOG ENOG4105BZS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZS epestfind swissprot:ACRF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ACRF_ECOLI garnier swissprot:ACRF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ACRF_ECOLI helixturnhelix swissprot:ACRF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ACRF_ECOLI hmoment swissprot:ACRF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ACRF_ECOLI iep swissprot:ACRF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ACRF_ECOLI inforesidue swissprot:ACRF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ACRF_ECOLI octanol swissprot:ACRF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ACRF_ECOLI pepcoil swissprot:ACRF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ACRF_ECOLI pepdigest swissprot:ACRF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ACRF_ECOLI pepinfo swissprot:ACRF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ACRF_ECOLI pepnet swissprot:ACRF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ACRF_ECOLI pepstats swissprot:ACRF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ACRF_ECOLI pepwheel swissprot:ACRF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ACRF_ECOLI pepwindow swissprot:ACRF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ACRF_ECOLI sigcleave swissprot:ACRF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ACRF_ECOLI ## Database ID URL or Descriptions # AltName KDGL_ECOLI Diglyceride kinase # BRENDA 2.7.1.107 2026 # BioGrid 4261719 272 # BioGrid 852837 2 # CATALYTIC ACTIVITY KDGL_ECOLI ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2- diacyl-sn-glycerol 3-phosphate. # CDD cd14264 DAGK_IM # EcoGene EG10224 dgkA # FUNCTION KDGL_ECOLI Recycling of diacylglycerol produced during the turnover of membrane phospholipid. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0004143 diacylglycerol kinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0006654 phosphatidic acid biosynthetic process; IDA:EcoCyc. # GO_process GO:0008654 phospholipid biosynthetic process; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # InterPro IPR000829 DAGK # InterPro IPR033718 DAGK_prok # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00561 Glycerolipid metabolism # KEGG_Pathway ko00564 Glycerophospholipid metabolism # KEGG_Pathway ko04070 Phosphatidylinositol signaling system # Organism KDGL_ECOLI Escherichia coli (strain K12) # PATRIC 32123621 VBIEscCol129921_4159 # PDB 2KDC NMR; -; A/B/C=2-122 # PDB 3ZE3 X-ray; 2.05 A; A/B/C/D/E/F=2-122 # PDB 3ZE4 X-ray; 3.70 A; A/B/C=2-122 # PDB 3ZE5 X-ray; 3.10 A; A/B/C=2-122 # PDB 4BPD X-ray; 3.30 A; A/B/C/D/E/F=2-122 # PDB 4BRB X-ray; 2.55 A; A/B/C/D/E/F=2-122 # PDB 4BRR X-ray; 2.44 A; A/B/C/D/E/F=2-122 # PDB 4CJZ X-ray; 3.25 A; A/B/C=2-122 # PDB 4CK0 X-ray; 2.92 A; A/B/C=2-122 # PDB 4D2E X-ray; 2.28 A; A/B/C/D/E/F=2-122 # PDB 4UP6 X-ray; 3.80 A; A/B/C=2-122 # PDB 4UXW X-ray; 3.15 A; A/B/C=2-122 # PDB 4UXX X-ray; 2.70 A; A/B/C=2-122 # PDB 4UXZ X-ray; 2.18 A; A/B/C/D/E/F=2-122 # PDB 4UYO X-ray; 2.18 A; A/B/C/D/E/F=2-122 # PDB 5D56 X-ray; 2.80 A; A/B/C/D/E/F=2-122 # PDB 5D57 X-ray; 2.80 A; A/B/C/D/E/F=2-122 # PDB 5D6I X-ray; 3.09 A; A/B/C=2-122 # PDB 5DWK X-ray; 2.60 A; A/B/C/D/E/F=2-122 # PIR A00667 KIECDG # PROSITE PS01069 DAGK_PROKAR # Pfam PF01219 DAGK_prokar # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName KDGL_ECOLI Diacylglycerol kinase # RefSeq NP_418466 NC_000913.3 # RefSeq WP_000002907 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial diacylglycerol kinase family. {ECO 0000305}. # SUBCELLULAR LOCATION KDGL_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG COG0818 LUCA # eggNOG ENOG41080IJ Bacteria BLAST swissprot:KDGL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:KDGL_ECOLI BioCyc ECOL316407:JW4002-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4002-MONOMER BioCyc EcoCyc:DIACYLGLYKIN-MONOMER http://biocyc.org/getid?id=EcoCyc:DIACYLGLYKIN-MONOMER BioCyc MetaCyc:DIACYLGLYKIN-MONOMER http://biocyc.org/getid?id=MetaCyc:DIACYLGLYKIN-MONOMER COG COG0818 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0818 DIP DIP-60228N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-60228N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.107 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.107 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K00127 http://www.ebi.ac.uk/ena/data/view/K00127 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.107 http://enzyme.expasy.org/EC/2.7.1.107 EchoBASE EB0220 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0220 EcoGene EG10224 http://www.ecogene.org/geneInfo.php?eg_id=EG10224 EnsemblBacteria AAC77012 http://www.ensemblgenomes.org/id/AAC77012 EnsemblBacteria AAC77012 http://www.ensemblgenomes.org/id/AAC77012 EnsemblBacteria BAE78044 http://www.ensemblgenomes.org/id/BAE78044 EnsemblBacteria BAE78044 http://www.ensemblgenomes.org/id/BAE78044 EnsemblBacteria BAE78044 http://www.ensemblgenomes.org/id/BAE78044 EnsemblBacteria b4042 http://www.ensemblgenomes.org/id/b4042 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0004143 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004143 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006654 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006654 GO_process GO:0008654 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008654 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 948543 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948543 HOGENOM HOG000014819 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000014819&db=HOGENOM6 InParanoid P0ABN1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABN1 IntEnz 2.7.1.107 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.107 InterPro IPR000829 http://www.ebi.ac.uk/interpro/entry/IPR000829 InterPro IPR033718 http://www.ebi.ac.uk/interpro/entry/IPR033718 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4002 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4002 KEGG_Gene eco:b4042 http://www.genome.jp/dbget-bin/www_bget?eco:b4042 KEGG_Orthology KO:K00901 http://www.genome.jp/dbget-bin/www_bget?KO:K00901 KEGG_Pathway ko00561 http://www.genome.jp/kegg-bin/show_pathway?ko00561 KEGG_Pathway ko00564 http://www.genome.jp/kegg-bin/show_pathway?ko00564 KEGG_Pathway ko04070 http://www.genome.jp/kegg-bin/show_pathway?ko04070 KEGG_Reaction rn:R02240 http://www.genome.jp/dbget-bin/www_bget?rn:R02240 OMA ITNEWHE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ITNEWHE PDB 2KDC http://www.ebi.ac.uk/pdbe-srv/view/entry/2KDC PDB 3ZE3 http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZE3 PDB 3ZE4 http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZE4 PDB 3ZE5 http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZE5 PDB 4BPD http://www.ebi.ac.uk/pdbe-srv/view/entry/4BPD PDB 4BRB http://www.ebi.ac.uk/pdbe-srv/view/entry/4BRB PDB 4BRR http://www.ebi.ac.uk/pdbe-srv/view/entry/4BRR PDB 4CJZ http://www.ebi.ac.uk/pdbe-srv/view/entry/4CJZ PDB 4CK0 http://www.ebi.ac.uk/pdbe-srv/view/entry/4CK0 PDB 4D2E http://www.ebi.ac.uk/pdbe-srv/view/entry/4D2E PDB 4UP6 http://www.ebi.ac.uk/pdbe-srv/view/entry/4UP6 PDB 4UXW http://www.ebi.ac.uk/pdbe-srv/view/entry/4UXW PDB 4UXX http://www.ebi.ac.uk/pdbe-srv/view/entry/4UXX PDB 4UXZ http://www.ebi.ac.uk/pdbe-srv/view/entry/4UXZ PDB 4UYO http://www.ebi.ac.uk/pdbe-srv/view/entry/4UYO PDB 5D56 http://www.ebi.ac.uk/pdbe-srv/view/entry/5D56 PDB 5D57 http://www.ebi.ac.uk/pdbe-srv/view/entry/5D57 PDB 5D6I http://www.ebi.ac.uk/pdbe-srv/view/entry/5D6I PDB 5DWK http://www.ebi.ac.uk/pdbe-srv/view/entry/5DWK PDBsum 2KDC http://www.ebi.ac.uk/pdbsum/2KDC PDBsum 3ZE3 http://www.ebi.ac.uk/pdbsum/3ZE3 PDBsum 3ZE4 http://www.ebi.ac.uk/pdbsum/3ZE4 PDBsum 3ZE5 http://www.ebi.ac.uk/pdbsum/3ZE5 PDBsum 4BPD http://www.ebi.ac.uk/pdbsum/4BPD PDBsum 4BRB http://www.ebi.ac.uk/pdbsum/4BRB PDBsum 4BRR http://www.ebi.ac.uk/pdbsum/4BRR PDBsum 4CJZ http://www.ebi.ac.uk/pdbsum/4CJZ PDBsum 4CK0 http://www.ebi.ac.uk/pdbsum/4CK0 PDBsum 4D2E http://www.ebi.ac.uk/pdbsum/4D2E PDBsum 4UP6 http://www.ebi.ac.uk/pdbsum/4UP6 PDBsum 4UXW http://www.ebi.ac.uk/pdbsum/4UXW PDBsum 4UXX http://www.ebi.ac.uk/pdbsum/4UXX PDBsum 4UXZ http://www.ebi.ac.uk/pdbsum/4UXZ PDBsum 4UYO http://www.ebi.ac.uk/pdbsum/4UYO PDBsum 5D56 http://www.ebi.ac.uk/pdbsum/5D56 PDBsum 5D57 http://www.ebi.ac.uk/pdbsum/5D57 PDBsum 5D6I http://www.ebi.ac.uk/pdbsum/5D6I PDBsum 5DWK http://www.ebi.ac.uk/pdbsum/5DWK PROSITE PS01069 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01069 PSORT swissprot:KDGL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:KDGL_ECOLI PSORT-B swissprot:KDGL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:KDGL_ECOLI PSORT2 swissprot:KDGL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:KDGL_ECOLI Pfam PF01219 http://pfam.xfam.org/family/PF01219 Phobius swissprot:KDGL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:KDGL_ECOLI PhylomeDB P0ABN1 http://phylomedb.org/?seqid=P0ABN1 ProteinModelPortal P0ABN1 http://www.proteinmodelportal.org/query/uniprot/P0ABN1 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2984194 http://www.ncbi.nlm.nih.gov/pubmed/2984194 PubMed 6309817 http://www.ncbi.nlm.nih.gov/pubmed/6309817 PubMed 8071224 http://www.ncbi.nlm.nih.gov/pubmed/8071224 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418466 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418466 RefSeq WP_000002907 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000002907 SMR P0ABN1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABN1 STRING 511145.b4042 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4042&targetmode=cogs STRING COG0818 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0818&targetmode=cogs UniProtKB KDGL_ECOLI http://www.uniprot.org/uniprot/KDGL_ECOLI UniProtKB-AC P0ABN1 http://www.uniprot.org/uniprot/P0ABN1 charge swissprot:KDGL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:KDGL_ECOLI eggNOG COG0818 http://eggnogapi.embl.de/nog_data/html/tree/COG0818 eggNOG ENOG41080IJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG41080IJ epestfind swissprot:KDGL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:KDGL_ECOLI garnier swissprot:KDGL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:KDGL_ECOLI helixturnhelix swissprot:KDGL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:KDGL_ECOLI hmoment swissprot:KDGL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:KDGL_ECOLI iep swissprot:KDGL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:KDGL_ECOLI inforesidue swissprot:KDGL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:KDGL_ECOLI octanol swissprot:KDGL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:KDGL_ECOLI pepcoil swissprot:KDGL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:KDGL_ECOLI pepdigest swissprot:KDGL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:KDGL_ECOLI pepinfo swissprot:KDGL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:KDGL_ECOLI pepnet swissprot:KDGL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:KDGL_ECOLI pepstats swissprot:KDGL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:KDGL_ECOLI pepwheel swissprot:KDGL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:KDGL_ECOLI pepwindow swissprot:KDGL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:KDGL_ECOLI sigcleave swissprot:KDGL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:KDGL_ECOLI ## Database ID URL or Descriptions # BioGrid 4261291 50 # DrugBank DB01361 Troleandomycin # EcoGene EG10867 rplD # FUNCTION RL4_ECOLI Can regulate expression from Citrobacter freundii, Haemophilus influenzae, Morganella morganii, Salmonella typhimurium, Serratia marcescens, Vibrio cholerae and Yersinia enterocolitica (but not Pseudomonas aeruginosa) S10 leaders in vitro. {ECO 0000269|PubMed 10498727}. # FUNCTION RL4_ECOLI Forms part of the polypeptide exit tunnel. {ECO 0000269|PubMed 11511371, ECO 0000269|PubMed 2442760}. # FUNCTION RL4_ECOLI One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. {ECO 0000269|PubMed 2442760, ECO 0000269|PubMed 3298242}. # FUNCTION RL4_ECOLI Protein L4 is a both a transcriptional repressor and a translational repressor protein; these two functions are independent of each other. It regulates transcription of the S10 operon (to which L4 belongs) by causing premature termination of transcription within the S10 leader; termination absolutely requires the NusA protein. L4 controls the translation of the S10 operon by binding to its mRNA. The regions of L4 that control regulation (residues 131-210) are different from those required for ribosome assembly (residues 89-103). {ECO 0000269|PubMed 13130133, ECO 0000269|PubMed 1692593, ECO 0000269|PubMed 2157208, ECO 0000269|PubMed 2442760}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0022625 cytosolic large ribosomal subunit; IDA:EcoCyc. # GO_function GO:0003723 RNA binding; IBA:GO_Central. # GO_function GO:0003735 structural constituent of ribosome; IBA:GO_Central. # GO_function GO:0019843 rRNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0030371 translation repressor activity; IDA:EcoliWiki. # GO_function GO:0060698 endoribonuclease inhibitor activity; IDA:EcoCyc. # GO_process GO:0006353 DNA-templated transcription, termination; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006412 translation; IEA:UniProtKB-HAMAP. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GO_process GO:0060702 negative regulation of endoribonuclease activity; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_function GO:0019843 rRNA binding # GOslim_function GO:0030234 enzyme regulator activity # GOslim_process GO:0006412 translation # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.1370.10 -; 1. # HAMAP MF_01328_B Ribosomal_L4_B # IntAct P60723 214 # InterPro IPR002136 Ribosomal_L4/L1e # InterPro IPR013005 Ribosomal_uL4/L1e # InterPro IPR023574 Ribosomal_L4_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=22086.2; Method=MALDI; Range=1-201; Evidence={ECO:0000269|PubMed 10094780}; # MISCELLANEOUS RL4_ECOLI The erythromycin sensitive allele is dominant over the resistant allele. # Organism RL4_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10746 PTHR10746 # PATRIC 32122070 VBIEscCol129921_3412 # PDB 2J28 EM; 8.00 A; E=1-201 # PDB 2RDO EM; 9.10 A; E=1-201 # PDB 3BBX EM; 10.00 A; E=1-201 # PDB 3J5L EM; 6.60 A; E=1-201 # PDB 3J7Z EM; 3.90 A; E=1-201 # PDB 3J8G EM; 5.00 A; E=1-201 # PDB 3J9Y EM; 3.90 A; E=1-201 # PDB 3J9Z EM; 3.60 A; L6=1-201 # PDB 3JA1 EM; 3.60 A; LF=1-201 # PDB 3JBU EM; 3.64 A; e=1-201 # PDB 3JBV EM; 3.32 A; e=1-201 # PDB 3JCD EM; 3.70 A; E=1-201 # PDB 3JCE EM; 3.20 A; E=1-201 # PDB 3JCJ EM; 3.70 A; D=1-201 # PDB 3JCN EM; 4.60 A; E=1-201 # PDB 4CSU EM; 5.50 A; E=1-201 # PDB 4U1U X-ray; 2.95 A; BE/DE=1-201 # PDB 4U1V X-ray; 3.00 A; BE/DE=1-201 # PDB 4U20 X-ray; 2.90 A; BE/DE=1-201 # PDB 4U24 X-ray; 2.90 A; BE/DE=1-201 # PDB 4U25 X-ray; 2.90 A; BE/DE=1-201 # PDB 4U26 X-ray; 2.80 A; BE/DE=1-201 # PDB 4U27 X-ray; 2.80 A; BE/DE=1-201 # PDB 4UY8 EM; 3.80 A; E=1-201 # PDB 4V47 EM; 12.30 A; AC=1-201 # PDB 4V48 EM; 11.50 A; AC=1-201 # PDB 4V4H X-ray; 3.46 A; BE/DE=1-201 # PDB 4V4Q X-ray; 3.46 A; BE/DE=1-201 # PDB 4V4V EM; 15.00 A; BC=1-198 # PDB 4V4W EM; 15.00 A; BC=1-198 # PDB 4V50 X-ray; 3.22 A; BE/DE=1-201 # PDB 4V52 X-ray; 3.21 A; BE/DE=1-201 # PDB 4V53 X-ray; 3.54 A; BE/DE=1-201 # PDB 4V54 X-ray; 3.30 A; BE/DE=1-201 # PDB 4V55 X-ray; 4.00 A; BE/DE=1-201 # PDB 4V56 X-ray; 3.93 A; BE/DE=1-201 # PDB 4V57 X-ray; 3.50 A; BE/DE=1-201 # PDB 4V5B X-ray; 3.74 A; AE/CE=1-201 # PDB 4V5H EM; 5.80 A; BE=1-201 # PDB 4V5Y X-ray; 4.45 A; BE/DE=1-201 # PDB 4V64 X-ray; 3.50 A; BE/DE=1-201 # PDB 4V65 EM; 9.00 A; B1=1-201 # PDB 4V66 EM; 9.00 A; B1=1-201 # PDB 4V69 EM; 6.70 A; BE=1-201 # PDB 4V6C X-ray; 3.19 A; BE/DE=1-201 # PDB 4V6D X-ray; 3.81 A; BE/DE=1-201 # PDB 4V6E X-ray; 3.71 A; BE/DE=1-201 # PDB 4V6K EM; 8.25 A; AF=1-201 # PDB 4V6L EM; 13.20 A; BF=1-201 # PDB 4V6M EM; 7.10 A; BE=1-201 # PDB 4V6N EM; 12.10 A; AF=1-201 # PDB 4V6O EM; 14.70 A; BF=1-201 # PDB 4V6P EM; 13.50 A; BF=1-201 # PDB 4V6Q EM; 11.50 A; BF=1-201 # PDB 4V6R EM; 11.50 A; BF=1-201 # PDB 4V6S EM; 13.10 A; AF=1-201 # PDB 4V6T EM; 8.30 A; BE=1-201 # PDB 4V6V EM; 9.80 A; BF=1-201 # PDB 4V6Y EM; 12.00 A; BE=1-201 # PDB 4V6Z EM; 12.00 A; BE=1-201 # PDB 4V70 EM; 17.00 A; BE=1-201 # PDB 4V71 EM; 20.00 A; BE=1-201 # PDB 4V72 EM; 13.00 A; BE=1-201 # PDB 4V73 EM; 15.00 A; BE=1-201 # PDB 4V74 EM; 17.00 A; BE=1-201 # PDB 4V75 EM; 12.00 A; BE=1-201 # PDB 4V76 EM; 17.00 A; BE=1-201 # PDB 4V77 EM; 17.00 A; BE=1-201 # PDB 4V78 EM; 20.00 A; BE=1-201 # PDB 4V79 EM; 15.00 A; BE=1-201 # PDB 4V7A EM; 9.00 A; BE=1-201 # PDB 4V7B EM; 6.80 A; BE=1-201 # PDB 4V7C EM; 7.60 A; BF=1-201 # PDB 4V7D EM; 7.60 A; AF=1-201 # PDB 4V7I EM; 9.60 A; AE=1-201 # PDB 4V7S X-ray; 3.25 A; BE/DE=1-201 # PDB 4V7T X-ray; 3.19 A; BE/DE=1-201 # PDB 4V7U X-ray; 3.10 A; BE/DE=1-201 # PDB 4V7V X-ray; 3.29 A; BE/DE=1-201 # PDB 4V85 X-ray; 3.20 A; E=1-201 # PDB 4V89 X-ray; 3.70 A; BE=1-201 # PDB 4V9C X-ray; 3.30 A; BE/DE=1-201 # PDB 4V9D X-ray; 3.00 A; CE/DE=1-201 # PDB 4V9O X-ray; 2.90 A; AE/CE/EE/GE=1-201 # PDB 4V9P X-ray; 2.90 A; AE/CE/EE/GE=1-201 # PDB 4WF1 X-ray; 3.09 A; BE/DE=1-201 # PDB 4WOI X-ray; 3.00 A; BE/CE=1-201 # PDB 4WWW X-ray; 3.10 A; RE/YE=1-201 # PDB 4YBB X-ray; 2.10 A; CE/DE=1-201 # PDB 5ADY EM; 4.50 A; E=1-201 # PDB 5AFI EM; 2.90 A; E=1-201 # PDB 5AKA EM; 5.70 A; E=1-201 # PDB 5GAD EM; 3.70 A; E=1-201 # PDB 5GAE EM; 3.33 A; E=1-201 # PDB 5GAF EM; 4.30 A; E=1-201 # PDB 5GAG EM; 3.80 A; E=1-201 # PDB 5GAH EM; 3.80 A; E=1-201 # PDB 5IQR EM; 3.00 A; D=1-201 # PDB 5IT8 X-ray; 3.12 A; CE/DE=1-201 # PDB 5J5B X-ray; 2.80 A; CE/DE=1-201 # PDB 5J7L X-ray; 3.00 A; CE/DE=1-201 # PDB 5J88 X-ray; 3.32 A; CE/DE=1-201 # PDB 5J8A X-ray; 3.10 A; CE/DE=1-201 # PDB 5J91 X-ray; 2.96 A; CE/DE=1-201 # PDB 5JC9 X-ray; 3.03 A; CE/DE=1-201 # PDB 5JTE EM; 3.60 A; BE=1-201 # PDB 5JU8 EM; 3.60 A; BE=1-201 # PDB 5KCR EM; 3.60 A; 1F=1-201 # PDB 5KCS EM; 3.90 A; 1F=1-201 # PDB 5KPS EM; 3.90 A; D=1-201 # PDB 5KPV EM; 4.10 A; C=1-201 # PDB 5KPW EM; 3.90 A; C=1-201 # PDB 5KPX EM; 3.90 A; C=1-201 # PDB 5L3P EM; 3.70 A; F=1-201 # PIR C23129 R5EC4 # Pfam PF00573 Ribosomal_L4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RL4_ECOLI 50S ribosomal protein L4 # RefSeq NP_417778 NC_000913.3 # RefSeq WP_000424395 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein L4P family. {ECO 0000305}. # SUBUNIT RL4_ECOLI Part of the 50S ribosomal subunit. # SUPFAM SSF52166 SSF52166 # TIGRFAMs TIGR03953 rplD_bact # eggNOG COG0088 LUCA BLAST swissprot:RL4_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RL4_ECOLI BioCyc ECOL316407:JW3281-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3281-MONOMER BioCyc EcoCyc:EG10867-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10867-MONOMER BioCyc MetaCyc:EG10867-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10867-MONOMER COG COG0088 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0088 DIP DIP-35791N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35791N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1007/BF00295501 http://dx.doi.org/10.1007/BF00295501 DOI 10.1007/BF00333665 http://dx.doi.org/10.1007/BF00333665 DOI 10.1016/S0022-2836(05)80122-6 http://dx.doi.org/10.1016/S0022-2836(05)80122-6 DOI 10.1016/S0092-8674(03)00427-6 http://dx.doi.org/10.1016/S0092-8674(03)00427-6 DOI 10.1016/S1097-2765(01)00293-3 http://dx.doi.org/10.1016/S1097-2765(01)00293-3 DOI 10.1016/j.celrep.2014.09.011 http://dx.doi.org/10.1016/j.celrep.2014.09.011 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.84.18.6516 http://dx.doi.org/10.1073/pnas.84.18.6516 DOI 10.1073/pnas.87.7.2675 http://dx.doi.org/10.1073/pnas.87.7.2675 DOI 10.1093/nar/13.12.4521 http://dx.doi.org/10.1093/nar/13.12.4521 DOI 10.1093/nar/9.17.4285 http://dx.doi.org/10.1093/nar/9.17.4285 DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1261/rna.5400703 http://dx.doi.org/10.1261/rna.5400703 DOI 10.1371/journal.pbio.1001866 http://dx.doi.org/10.1371/journal.pbio.1001866 DisProt DP00600 http://www.disprot.org/protein.php?id=DP00600 DrugBank DB01361 http://www.drugbank.ca/drugs/DB01361 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X02613 http://www.ebi.ac.uk/ena/data/view/X02613 EchoBASE EB0860 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0860 EcoGene EG10867 http://www.ecogene.org/geneInfo.php?eg_id=EG10867 EnsemblBacteria AAC76344 http://www.ensemblgenomes.org/id/AAC76344 EnsemblBacteria AAC76344 http://www.ensemblgenomes.org/id/AAC76344 EnsemblBacteria BAE77972 http://www.ensemblgenomes.org/id/BAE77972 EnsemblBacteria BAE77972 http://www.ensemblgenomes.org/id/BAE77972 EnsemblBacteria BAE77972 http://www.ensemblgenomes.org/id/BAE77972 EnsemblBacteria b3319 http://www.ensemblgenomes.org/id/b3319 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0022625 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022625 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GO_function GO:0030371 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030371 GO_function GO:0060698 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060698 GO_process GO:0006353 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006353 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GO_process GO:0060702 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060702 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.1370.10 http://www.cathdb.info/version/latest/superfamily/3.40.1370.10 GeneID 5548703 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5548703 GeneID 947818 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947818 HAMAP MF_01328_B http://hamap.expasy.org/unirule/MF_01328_B HOGENOM HOG000248766 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000248766&db=HOGENOM6 InParanoid P60723 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P60723 IntAct P60723 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P60723* InterPro IPR002136 http://www.ebi.ac.uk/interpro/entry/IPR002136 InterPro IPR013005 http://www.ebi.ac.uk/interpro/entry/IPR013005 InterPro IPR023574 http://www.ebi.ac.uk/interpro/entry/IPR023574 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW3281 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3281 KEGG_Gene eco:b3319 http://www.genome.jp/dbget-bin/www_bget?eco:b3319 KEGG_Orthology KO:K02926 http://www.genome.jp/dbget-bin/www_bget?KO:K02926 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 MINT MINT-1219709 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1219709 OMA GVSHGPS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GVSHGPS PANTHER PTHR10746 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10746 PDB 2J28 http://www.ebi.ac.uk/pdbe-srv/view/entry/2J28 PDB 2RDO http://www.ebi.ac.uk/pdbe-srv/view/entry/2RDO PDB 3BBX http://www.ebi.ac.uk/pdbe-srv/view/entry/3BBX PDB 3J5L http://www.ebi.ac.uk/pdbe-srv/view/entry/3J5L PDB 3J7Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J7Z PDB 3J8G http://www.ebi.ac.uk/pdbe-srv/view/entry/3J8G PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 4CSU http://www.ebi.ac.uk/pdbe-srv/view/entry/4CSU PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4UY8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4UY8 PDB 4V47 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V47 PDB 4V48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V48 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5ADY http://www.ebi.ac.uk/pdbe-srv/view/entry/5ADY PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5AKA http://www.ebi.ac.uk/pdbe-srv/view/entry/5AKA PDB 5GAD http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAD PDB 5GAE http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAE PDB 5GAF http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAF PDB 5GAG http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAG PDB 5GAH http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAH PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 2J28 http://www.ebi.ac.uk/pdbsum/2J28 PDBsum 2RDO http://www.ebi.ac.uk/pdbsum/2RDO PDBsum 3BBX http://www.ebi.ac.uk/pdbsum/3BBX PDBsum 3J5L http://www.ebi.ac.uk/pdbsum/3J5L PDBsum 3J7Z http://www.ebi.ac.uk/pdbsum/3J7Z PDBsum 3J8G http://www.ebi.ac.uk/pdbsum/3J8G PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 4CSU http://www.ebi.ac.uk/pdbsum/4CSU PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4UY8 http://www.ebi.ac.uk/pdbsum/4UY8 PDBsum 4V47 http://www.ebi.ac.uk/pdbsum/4V47 PDBsum 4V48 http://www.ebi.ac.uk/pdbsum/4V48 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5ADY http://www.ebi.ac.uk/pdbsum/5ADY PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5AKA http://www.ebi.ac.uk/pdbsum/5AKA PDBsum 5GAD http://www.ebi.ac.uk/pdbsum/5GAD PDBsum 5GAE http://www.ebi.ac.uk/pdbsum/5GAE PDBsum 5GAF http://www.ebi.ac.uk/pdbsum/5GAF PDBsum 5GAG http://www.ebi.ac.uk/pdbsum/5GAG PDBsum 5GAH http://www.ebi.ac.uk/pdbsum/5GAH PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PSORT swissprot:RL4_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RL4_ECOLI PSORT-B swissprot:RL4_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RL4_ECOLI PSORT2 swissprot:RL4_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RL4_ECOLI Pfam PF00573 http://pfam.xfam.org/family/PF00573 Phobius swissprot:RL4_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RL4_ECOLI PhylomeDB P60723 http://phylomedb.org/?seqid=P60723 ProteinModelPortal P60723 http://www.proteinmodelportal.org/query/uniprot/P60723 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 10498727 http://www.ncbi.nlm.nih.gov/pubmed/10498727 PubMed 11511371 http://www.ncbi.nlm.nih.gov/pubmed/11511371 PubMed 12809609 http://www.ncbi.nlm.nih.gov/pubmed/12809609 PubMed 13130133 http://www.ncbi.nlm.nih.gov/pubmed/13130133 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1692593 http://www.ncbi.nlm.nih.gov/pubmed/1692593 PubMed 2157208 http://www.ncbi.nlm.nih.gov/pubmed/2157208 PubMed 2442760 http://www.ncbi.nlm.nih.gov/pubmed/2442760 PubMed 24844575 http://www.ncbi.nlm.nih.gov/pubmed/24844575 PubMed 25310980 http://www.ncbi.nlm.nih.gov/pubmed/25310980 PubMed 3298242 http://www.ncbi.nlm.nih.gov/pubmed/3298242 PubMed 3892488 http://www.ncbi.nlm.nih.gov/pubmed/3892488 PubMed 4589347 http://www.ncbi.nlm.nih.gov/pubmed/4589347 PubMed 6170935 http://www.ncbi.nlm.nih.gov/pubmed/6170935 PubMed 7556101 http://www.ncbi.nlm.nih.gov/pubmed/7556101 PubMed 7766155 http://www.ncbi.nlm.nih.gov/pubmed/7766155 PubMed 7928988 http://www.ncbi.nlm.nih.gov/pubmed/7928988 PubMed 8846294 http://www.ncbi.nlm.nih.gov/pubmed/8846294 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_417778 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417778 RefSeq WP_000424395 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000424395 SMR P60723 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P60723 STRING 511145.b3319 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3319&targetmode=cogs STRING COG0088 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0088&targetmode=cogs SUPFAM SSF52166 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52166 TIGRFAMs TIGR03953 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03953 UniProtKB RL4_ECOLI http://www.uniprot.org/uniprot/RL4_ECOLI UniProtKB-AC P60723 http://www.uniprot.org/uniprot/P60723 charge swissprot:RL4_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RL4_ECOLI eggNOG COG0088 http://eggnogapi.embl.de/nog_data/html/tree/COG0088 epestfind swissprot:RL4_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RL4_ECOLI garnier swissprot:RL4_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RL4_ECOLI helixturnhelix swissprot:RL4_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RL4_ECOLI hmoment swissprot:RL4_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RL4_ECOLI iep swissprot:RL4_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RL4_ECOLI inforesidue swissprot:RL4_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RL4_ECOLI octanol swissprot:RL4_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RL4_ECOLI pepcoil swissprot:RL4_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RL4_ECOLI pepdigest swissprot:RL4_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RL4_ECOLI pepinfo swissprot:RL4_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RL4_ECOLI pepnet swissprot:RL4_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RL4_ECOLI pepstats swissprot:RL4_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RL4_ECOLI pepwheel swissprot:RL4_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RL4_ECOLI pepwindow swissprot:RL4_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RL4_ECOLI sigcleave swissprot:RL4_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RL4_ECOLI ## Database ID URL or Descriptions # AltName YJJB_ECOLI Protein P-14 # BioGrid 4262775 229 # EcoGene EG11215 yjjB # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006970 response to osmotic stress; IMP:EcoCyc. # GO_process GO:1901652 response to peptide; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # HAMAP MF_01191 UPF0442 # InterPro IPR020914 UPF0442 # InterPro IPR024528 ThrE_2 # Organism YJJB_ECOLI Escherichia coli (strain K12) # PATRIC 32124334 VBIEscCol129921_4510 # PIR S56590 RMEC14 # Pfam PF12821 ThrE_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJJB_ECOLI UPF0442 protein YjjB # RefSeq NP_418783 NC_000913.3 # RefSeq WP_000538191 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA23698.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAA97262.1; Type=Erroneous initiation; Evidence={ECO 0000305}; Sequence=BAE78353.1; Type=Erroneous initiation; Evidence={ECO:0000305}; # SIMILARITY Belongs to the UPF0442 family. {ECO 0000305}. # SUBCELLULAR LOCATION YJJB_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # eggNOG COG3610 LUCA # eggNOG ENOG4107XM3 Bacteria BLAST swissprot:YJJB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJJB_ECOLI BioCyc ECOL316407:JW4327-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4327-MONOMER BioCyc EcoCyc:EG11215-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11215-MONOMER DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J04030 http://www.ebi.ac.uk/ena/data/view/J04030 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB1199 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1199 EcoGene EG11215 http://www.ecogene.org/geneInfo.php?eg_id=EG11215 EnsemblBacteria AAC77319 http://www.ensemblgenomes.org/id/AAC77319 EnsemblBacteria AAC77319 http://www.ensemblgenomes.org/id/AAC77319 EnsemblBacteria BAE78353 http://www.ensemblgenomes.org/id/BAE78353 EnsemblBacteria BAE78353 http://www.ensemblgenomes.org/id/BAE78353 EnsemblBacteria BAE78353 http://www.ensemblgenomes.org/id/BAE78353 EnsemblBacteria b4363 http://www.ensemblgenomes.org/id/b4363 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006970 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006970 GO_process GO:1901652 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901652 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 948811 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948811 HAMAP MF_01191 http://hamap.expasy.org/unirule/MF_01191 HOGENOM HOG000282049 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000282049&db=HOGENOM6 InParanoid P0ADD2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADD2 InterPro IPR020914 http://www.ebi.ac.uk/interpro/entry/IPR020914 InterPro IPR024528 http://www.ebi.ac.uk/interpro/entry/IPR024528 KEGG_Gene ecj:JW4327 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4327 KEGG_Gene eco:b4363 http://www.genome.jp/dbget-bin/www_bget?eco:b4363 OMA IPIEWAT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IPIEWAT PSORT swissprot:YJJB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJJB_ECOLI PSORT-B swissprot:YJJB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJJB_ECOLI PSORT2 swissprot:YJJB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJJB_ECOLI Pfam PF12821 http://pfam.xfam.org/family/PF12821 Phobius swissprot:YJJB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJJB_ECOLI ProteinModelPortal P0ADD2 http://www.proteinmodelportal.org/query/uniprot/P0ADD2 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2844800 http://www.ncbi.nlm.nih.gov/pubmed/2844800 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_418783 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418783 RefSeq WP_000538191 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000538191 STRING 511145.b4363 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4363&targetmode=cogs UniProtKB YJJB_ECOLI http://www.uniprot.org/uniprot/YJJB_ECOLI UniProtKB-AC P0ADD2 http://www.uniprot.org/uniprot/P0ADD2 charge swissprot:YJJB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJJB_ECOLI eggNOG COG3610 http://eggnogapi.embl.de/nog_data/html/tree/COG3610 eggNOG ENOG4107XM3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107XM3 epestfind swissprot:YJJB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJJB_ECOLI garnier swissprot:YJJB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJJB_ECOLI helixturnhelix swissprot:YJJB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJJB_ECOLI hmoment swissprot:YJJB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJJB_ECOLI iep swissprot:YJJB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJJB_ECOLI inforesidue swissprot:YJJB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJJB_ECOLI octanol swissprot:YJJB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJJB_ECOLI pepcoil swissprot:YJJB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJJB_ECOLI pepdigest swissprot:YJJB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJJB_ECOLI pepinfo swissprot:YJJB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJJB_ECOLI pepnet swissprot:YJJB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJJB_ECOLI pepstats swissprot:YJJB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJJB_ECOLI pepwheel swissprot:YJJB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJJB_ECOLI pepwindow swissprot:YJJB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJJB_ECOLI sigcleave swissprot:YJJB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJJB_ECOLI ## Database ID URL or Descriptions # AltName LYSD_ECOLI Endolysin # AltName LYSD_ECOLI Lysis protein # AltName LYSD_ECOLI Muramidase # BioGrid 4259885 4 # CATALYTIC ACTIVITY LYSD_ECOLI Hydrolysis of (1->4)-beta-linkages between N- acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. # CAZy GH24 Glycoside Hydrolase Family 24 # CDD cd00737 endolysin_autolysin # DISRUPTION PHENOTYPE Mutants are unable to form wild-type biofilms, which could be due to altered peptidoglycan metabolism. {ECO:0000269|PubMed 21415116}. # EcoGene EG13635 rrrD # FUNCTION LYSD_ECOLI Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity. Exhibits lytic activity against E.coli and S.typhi cell wall substrate. {ECO 0000269|PubMed 17914239}. # GO_function GO:0003796 lysozyme activity; IDA:EcoCyc. # GO_process GO:0009253 peptidoglycan catabolic process; IEA:InterPro. # GO_process GO:0016998 cell wall macromolecule catabolic process; IEA:InterPro. # GO_process GO:0042742 defense response to bacterium; IEA:UniProtKB-KW. # GO_process GO:0044659 cytolysis by virus of host cell; IMP:EcoCyc. # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0040011 locomotion # GOslim_process GO:0044403 symbiosis, encompassing mutualism through parasitism # Gene3D 1.10.530.40 -; 1. # IntAct P78285 3 # InterPro IPR002196 Glyco_hydro_24 # InterPro IPR023346 Lysozyme-like_dom # InterPro IPR023347 Lysozyme_dom # InterPro IPR033907 Endolysin_autolysin # KEGG_Brite ko01000 Enzymes # MISCELLANEOUS LYSD_ECOLI Encoded by the cryptic lambdoid prophage DLP12. # Organism LYSD_ECOLI Escherichia coli (strain K12) # PATRIC 32116276 VBIEscCol129921_0578 # PDB 4ZPU X-ray; 2.40 A; A/B/C/D=1-165 # PIR A64788 A64788 # Pfam PF00959 Phage_lysozyme # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LYSD_ECOLI Lysozyme RrrD # RefSeq NP_415087 NC_000913.3 # RefSeq WP_001135281 NZ_CP014272.1 # SIMILARITY Belongs to the glycosyl hydrolase 24 family. {ECO 0000305}. # SUPFAM SSF53955 SSF53955 # eggNOG COG3772 LUCA # eggNOG ENOG4105KUS Bacteria BLAST swissprot:LYSD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LYSD_ECOLI BioCyc ECOL316407:JW0544-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0544-MONOMER BioCyc EcoCyc:G6310-MONOMER http://biocyc.org/getid?id=EcoCyc:G6310-MONOMER BioCyc MetaCyc:G6310-MONOMER http://biocyc.org/getid?id=MetaCyc:G6310-MONOMER COG COG3772 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3772 DOI 10.1007/s12038-007-0097-x http://dx.doi.org/10.1007/s12038-007-0097-x DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1099/mic.0.045161-0 http://dx.doi.org/10.1099/mic.0.045161-0 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.2.1.17 http://www.genome.jp/dbget-bin/www_bget?EC:3.2.1.17 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 ENZYME 3.2.1.17 http://enzyme.expasy.org/EC/3.2.1.17 EchoBASE EB3399 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3399 EcoGene EG13635 http://www.ecogene.org/geneInfo.php?eg_id=EG13635 EnsemblBacteria AAC73656 http://www.ensemblgenomes.org/id/AAC73656 EnsemblBacteria AAC73656 http://www.ensemblgenomes.org/id/AAC73656 EnsemblBacteria BAE76330 http://www.ensemblgenomes.org/id/BAE76330 EnsemblBacteria BAE76330 http://www.ensemblgenomes.org/id/BAE76330 EnsemblBacteria BAE76330 http://www.ensemblgenomes.org/id/BAE76330 EnsemblBacteria b0555 http://www.ensemblgenomes.org/id/b0555 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003796 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003796 GO_process GO:0009253 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009253 GO_process GO:0016998 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016998 GO_process GO:0042742 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042742 GO_process GO:0044659 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044659 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0040011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011 GOslim_process GO:0044403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403 Gene3D 1.10.530.40 http://www.cathdb.info/version/latest/superfamily/1.10.530.40 GeneID 947539 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947539 HOGENOM HOG000277068 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000277068&db=HOGENOM6 InParanoid P78285 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P78285 IntAct P78285 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P78285* IntEnz 3.2.1.17 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.2.1.17 InterPro IPR002196 http://www.ebi.ac.uk/interpro/entry/IPR002196 InterPro IPR023346 http://www.ebi.ac.uk/interpro/entry/IPR023346 InterPro IPR023347 http://www.ebi.ac.uk/interpro/entry/IPR023347 InterPro IPR033907 http://www.ebi.ac.uk/interpro/entry/IPR033907 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0544 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0544 KEGG_Gene eco:b0555 http://www.genome.jp/dbget-bin/www_bget?eco:b0555 KEGG_Orthology KO:K01185 http://www.genome.jp/dbget-bin/www_bget?KO:K01185 OMA GACRAIN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GACRAIN PDB 4ZPU http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZPU PDBsum 4ZPU http://www.ebi.ac.uk/pdbsum/4ZPU PSORT swissprot:LYSD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LYSD_ECOLI PSORT-B swissprot:LYSD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LYSD_ECOLI PSORT2 swissprot:LYSD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LYSD_ECOLI Pfam PF00959 http://pfam.xfam.org/family/PF00959 Phobius swissprot:LYSD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LYSD_ECOLI PhylomeDB P78285 http://phylomedb.org/?seqid=P78285 ProteinModelPortal P78285 http://www.proteinmodelportal.org/query/uniprot/P78285 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17914239 http://www.ncbi.nlm.nih.gov/pubmed/17914239 PubMed 21415116 http://www.ncbi.nlm.nih.gov/pubmed/21415116 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415087 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415087 RefSeq WP_001135281 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001135281 SMR P78285 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P78285 STRING 511145.b0555 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0555&targetmode=cogs STRING COG3772 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3772&targetmode=cogs SUPFAM SSF53955 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53955 UniProtKB LYSD_ECOLI http://www.uniprot.org/uniprot/LYSD_ECOLI UniProtKB-AC P78285 http://www.uniprot.org/uniprot/P78285 charge swissprot:LYSD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LYSD_ECOLI eggNOG COG3772 http://eggnogapi.embl.de/nog_data/html/tree/COG3772 eggNOG ENOG4105KUS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KUS epestfind swissprot:LYSD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LYSD_ECOLI garnier swissprot:LYSD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LYSD_ECOLI helixturnhelix swissprot:LYSD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LYSD_ECOLI hmoment swissprot:LYSD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LYSD_ECOLI iep swissprot:LYSD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LYSD_ECOLI inforesidue swissprot:LYSD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LYSD_ECOLI octanol swissprot:LYSD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LYSD_ECOLI pepcoil swissprot:LYSD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LYSD_ECOLI pepdigest swissprot:LYSD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LYSD_ECOLI pepinfo swissprot:LYSD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LYSD_ECOLI pepnet swissprot:LYSD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LYSD_ECOLI pepstats swissprot:LYSD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LYSD_ECOLI pepwheel swissprot:LYSD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LYSD_ECOLI pepwindow swissprot:LYSD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LYSD_ECOLI sigcleave swissprot:LYSD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LYSD_ECOLI ## Database ID URL or Descriptions # AltName RIMK_ECOLI Polyglutamate synthase # AltName Ribosomal protein S6 modification protein {ECO:0000255|HAMAP-Rule MF_01552} # BIOPHYSICOCHEMICAL PROPERTIES RIMK_ECOLI pH dependence Optimum pH is 9.5 for RpsF modification and 9 for polyglutamate synthase activity. {ECO 0000269|PubMed 21278279}; Temperature dependence Shows thermal stability. Exhibits 86% activity after incubation at 55 degrees Celsius for 15 minutes, but its activity decreases sharply at 60 degrees Celsius. {ECO 0000269|PubMed 21278279}; # BIOTECHNOLOGY This protein may find application in fermentative methods that use microorganisms overexpressing rimK for mass production of poly-alpha-amino acids, which is thought to be the most economical and ecofriendly manufacturing process. {ECO:0000269|PubMed 21278279}. # BioGrid 4259992 11 # COFACTOR RIMK_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_01552}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000255|HAMAP-Rule MF_01552}; Note=Binds 2 magnesium or manganese ions per subunit. {ECO 0000255|HAMAP-Rule MF_01552}; # EcoGene EG10852 rimK # FUNCTION RIMK_ECOLI Is an L-glutamate ligase that catalyzes the ATP- dependent post-translational addition of glutamate residues to the C-terminus of ribosomal protein S6 (RpsF). Is also able to catalyze the synthesis of poly-alpha-glutamate in vitro, via ATP hydrolysis from unprotected glutamate as substrate. The number of glutamate residues added to either RpsF or to poly-alpha-glutamate changes with pH. {ECO 0000255|HAMAP-Rule MF_01552, ECO 0000269|PubMed 21278279, ECO 0000269|PubMed 2570347}. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0018169 ribosomal S6-glutamic acid ligase activity; IDA:EcoCyc. # GO_function GO:0030145 manganese ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0006412 translation; IEA:UniProtKB-KW. # GO_process GO:0009432 SOS response; IMP:EcoCyc. # GO_process GO:0018410 C-terminal protein amino acid modification; IMP:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006412 translation # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0006950 response to stress # Gene3D 3.30.1490.20 -; 1. # Gene3D 3.30.470.20 -; 1. # Gene3D 3.40.50.20 -; 1. # HAMAP MF_01552 RimK # IntAct P0C0U4 4 # InterPro IPR004666 RpS6_RimK/Lys_biosynth_LsyX # InterPro IPR011761 ATP-grasp # InterPro IPR013651 ATP-grasp_RimK-type # InterPro IPR013815 ATP_grasp_subdomain_1 # InterPro IPR013816 ATP_grasp_subdomain_2 # InterPro IPR016185 PreATP-grasp_dom # InterPro IPR023533 RimK # KEGG_Brite ko03009 Ribosome biogenesis # Organism RIMK_ECOLI Escherichia coli (strain K12) # PATRIC 32116909 VBIEscCol129921_0880 # PDB 4IWX X-ray; 2.85 A; A=1-300 # PDB 4IWY X-ray; 2.90 A; A=2-300 # PIR D64823 D64823 # PROSITE PS50975 ATP_GRASP # Pfam PF08443 RimK # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Ribosomal protein S6--L-glutamate ligase {ECO:0000255|HAMAP-Rule MF_01552} # RefSeq NP_415373 NC_000913.3 # RefSeq WP_000684321 NZ_LN832404.1 # SIMILARITY Belongs to the RimK family. {ECO:0000255|HAMAP- Rule MF_01552}. # SIMILARITY Contains 1 ATP-grasp domain. {ECO:0000255|HAMAP- Rule MF_01552}. # TIGRFAMs TIGR00768 rimK_fam # eggNOG COG0189 LUCA # eggNOG ENOG4105D9I Bacteria BLAST swissprot:RIMK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RIMK_ECOLI BioCyc ECOL316407:JW0836-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0836-MONOMER BioCyc EcoCyc:EG10852-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10852-MONOMER BioCyc MetaCyc:EG10852-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10852-MONOMER COG COG0189 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0189 DOI 10.1002/prot.24311 http://dx.doi.org/10.1002/prot.24311 DOI 10.1007/BF02464894 http://dx.doi.org/10.1007/BF02464894 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AEM.02043-10 http://dx.doi.org/10.1128/AEM.02043-10 EC_number EC:6.3.2.- {ECO:0000255|HAMAP-Rule:MF_01552} http://www.genome.jp/dbget-bin/www_bget?EC:6.3.2.- {ECO:0000255|HAMAP-Rule:MF_01552} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X15859 http://www.ebi.ac.uk/ena/data/view/X15859 ENZYME 6.3.2.- {ECO:0000255|HAMAP-Rule:MF_01552} http://enzyme.expasy.org/EC/6.3.2.- {ECO:0000255|HAMAP-Rule:MF_01552} EchoBASE EB0845 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0845 EcoGene EG10852 http://www.ecogene.org/geneInfo.php?eg_id=EG10852 EnsemblBacteria AAC73939 http://www.ensemblgenomes.org/id/AAC73939 EnsemblBacteria AAC73939 http://www.ensemblgenomes.org/id/AAC73939 EnsemblBacteria BAA35563 http://www.ensemblgenomes.org/id/BAA35563 EnsemblBacteria BAA35563 http://www.ensemblgenomes.org/id/BAA35563 EnsemblBacteria BAA35563 http://www.ensemblgenomes.org/id/BAA35563 EnsemblBacteria b0852 http://www.ensemblgenomes.org/id/b0852 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0018169 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018169 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GO_process GO:0009432 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009432 GO_process GO:0018410 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018410 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.30.1490.20 http://www.cathdb.info/version/latest/superfamily/3.30.1490.20 Gene3D 3.30.470.20 http://www.cathdb.info/version/latest/superfamily/3.30.470.20 Gene3D 3.40.50.20 http://www.cathdb.info/version/latest/superfamily/3.40.50.20 GeneID 945484 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945484 HAMAP MF_01552 http://hamap.expasy.org/unirule/MF_01552 HOGENOM HOG000293092 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000293092&db=HOGENOM6 InParanoid P0C0U4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0C0U4 IntAct P0C0U4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0C0U4* IntEnz 6.3.2.- {ECO:0000255|HAMAP-Rule:MF_01552} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.2.- {ECO:0000255|HAMAP-Rule:MF_01552} InterPro IPR004666 http://www.ebi.ac.uk/interpro/entry/IPR004666 InterPro IPR011761 http://www.ebi.ac.uk/interpro/entry/IPR011761 InterPro IPR013651 http://www.ebi.ac.uk/interpro/entry/IPR013651 InterPro IPR013815 http://www.ebi.ac.uk/interpro/entry/IPR013815 InterPro IPR013816 http://www.ebi.ac.uk/interpro/entry/IPR013816 InterPro IPR016185 http://www.ebi.ac.uk/interpro/entry/IPR016185 InterPro IPR023533 http://www.ebi.ac.uk/interpro/entry/IPR023533 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW0836 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0836 KEGG_Gene eco:b0852 http://www.genome.jp/dbget-bin/www_bget?eco:b0852 KEGG_Orthology KO:K05844 http://www.genome.jp/dbget-bin/www_bget?KO:K05844 OMA NYLRCYM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NYLRCYM PDB 4IWX http://www.ebi.ac.uk/pdbe-srv/view/entry/4IWX PDB 4IWY http://www.ebi.ac.uk/pdbe-srv/view/entry/4IWY PDBsum 4IWX http://www.ebi.ac.uk/pdbsum/4IWX PDBsum 4IWY http://www.ebi.ac.uk/pdbsum/4IWY PROSITE PS50975 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50975 PSORT swissprot:RIMK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RIMK_ECOLI PSORT-B swissprot:RIMK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RIMK_ECOLI PSORT2 swissprot:RIMK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RIMK_ECOLI Pfam PF08443 http://pfam.xfam.org/family/PF08443 Phobius swissprot:RIMK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RIMK_ECOLI PhylomeDB P0C0U4 http://phylomedb.org/?seqid=P0C0U4 ProteinModelPortal P0C0U4 http://www.proteinmodelportal.org/query/uniprot/P0C0U4 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21278279 http://www.ncbi.nlm.nih.gov/pubmed/21278279 PubMed 23609986 http://www.ncbi.nlm.nih.gov/pubmed/23609986 PubMed 2570347 http://www.ncbi.nlm.nih.gov/pubmed/2570347 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415373 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415373 RefSeq WP_000684321 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000684321 SMR P0C0U4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0C0U4 STRING 511145.b0852 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0852&targetmode=cogs STRING COG0189 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0189&targetmode=cogs TIGRFAMs TIGR00768 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00768 UniProtKB RIMK_ECOLI http://www.uniprot.org/uniprot/RIMK_ECOLI UniProtKB-AC P0C0U4 http://www.uniprot.org/uniprot/P0C0U4 charge swissprot:RIMK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RIMK_ECOLI eggNOG COG0189 http://eggnogapi.embl.de/nog_data/html/tree/COG0189 eggNOG ENOG4105D9I http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D9I epestfind swissprot:RIMK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RIMK_ECOLI garnier swissprot:RIMK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RIMK_ECOLI helixturnhelix swissprot:RIMK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RIMK_ECOLI hmoment swissprot:RIMK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RIMK_ECOLI iep swissprot:RIMK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RIMK_ECOLI inforesidue swissprot:RIMK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RIMK_ECOLI octanol swissprot:RIMK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RIMK_ECOLI pepcoil swissprot:RIMK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RIMK_ECOLI pepdigest swissprot:RIMK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RIMK_ECOLI pepinfo swissprot:RIMK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RIMK_ECOLI pepnet swissprot:RIMK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RIMK_ECOLI pepstats swissprot:RIMK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RIMK_ECOLI pepwheel swissprot:RIMK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RIMK_ECOLI pepwindow swissprot:RIMK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RIMK_ECOLI sigcleave swissprot:RIMK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RIMK_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES MSBA_ECOLI Kinetic parameters KM=878 uM for ATP {ECO 0000269|PubMed 12119303}; Vmax=37 nmol/min/mg enzyme {ECO 0000269|PubMed 12119303}; # BRENDA 3.6.3 2026 # BioGrid 4260013 191 # DOMAIN MSBA_ECOLI In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused. {ECO 0000305}. # ENZYME REGULATION ATPase activity is stimulated by hexaacylated lipid A. Inhibited by vanadate. {ECO:0000269|PubMed 12119303}. # EcoGene EG10613 msbA # FUNCTION MSBA_ECOLI Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. {ECO 0000269|PubMed 12119303, ECO 0000269|PubMed 8809774, ECO 0000269|PubMed 9575204}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IEA:UniProtKB-HAMAP. # GO_function GO:0005319 lipid transporter activity; IMP:EcoCyc. # GO_function GO:0005524 ATP binding; IDA:EcoCyc. # GO_function GO:0008144 drug binding; IDA:EcoliWiki. # GO_function GO:0008289 lipid binding; IDA:EcoliWiki. # GO_function GO:0015437 lipopolysaccharide-transporting ATPase activity; IDA:EcoCyc. # GO_function GO:0034040 lipid-transporting ATPase activity; IDA:EcoliWiki. # GO_process GO:0006869 lipid transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008289 lipid binding # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # Gene3D 3.40.50.300 -; 1. # IntAct P60752 2 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR011527 ABC1_TM_dom # InterPro IPR011917 ABC_transpr_lipidA # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism MSBA_ECOLI Escherichia coli (strain K12) # PATRIC 32117041 VBIEscCol129921_0945 # PDB 3B5W X-ray; 5.30 A; A/B/C/D/E/F/G/H=1-582 # PIR C85617 C85617 # PIR E90753 E90753 # PIR S27998 S27998 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # PROSITE PS50929 ABC_TM1F # PROSITE PS51239 MSBA # Pfam PF00005 ABC_tran # Pfam PF00664 ABC_membrane # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Lipid A export ATP-binding/permease protein MsbA {ECO:0000255|HAMAP-Rule MF_01703, ECO:0000305} # RefSeq NP_415434 NC_000913.3 # RefSeq WP_000551270 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. {ECO:0000255|HAMAP-Rule MF_01703}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|HAMAP-Rule MF_01703}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|HAMAP- Rule MF_01703}. # SMART SM00382 AAA # SUBCELLULAR LOCATION MSBA_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01703, ECO 0000269|PubMed 12119303, ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 8809774}; Multi- pass membrane protein {ECO 0000255|HAMAP-Rule MF_01703, ECO 0000269|PubMed 8809774}. # SUBUNIT MSBA_ECOLI Homodimer. {ECO 0000255|HAMAP-Rule MF_01703, ECO 0000269|PubMed 11546864}. # SUPFAM SSF52540 SSF52540 # SUPFAM SSF90123 SSF90123 # TCDB 3.A.1.106 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR02203 MsbA_lipidA # eggNOG COG1132 LUCA # eggNOG ENOG4105BZ1 Bacteria BLAST swissprot:MSBA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MSBA_ECOLI BioCyc ECOL316407:JW0897-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0897-MONOMER BioCyc EcoCyc:EG10613-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10613-MONOMER BioCyc MetaCyc:EG10613-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10613-MONOMER COG COG1132 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1132 DIP DIP-36229N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36229N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.273.20.12466 http://dx.doi.org/10.1074/jbc.273.20.12466 DOI 10.1074/jbc.C100091200 http://dx.doi.org/10.1074/jbc.C100091200 DOI 10.1074/jbc.M205857200 http://dx.doi.org/10.1074/jbc.M205857200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1993.tb01098.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb01098.x DOI 10.1111/j.1365-2958.1996.tb02642.x http://dx.doi.org/10.1111/j.1365-2958.1996.tb02642.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1126/science.293.5536.1793 http://dx.doi.org/10.1126/science.293.5536.1793 DOI 10.1126/science.314.5807.1875b http://dx.doi.org/10.1126/science.314.5807.1875b DisProt DP00400 http://www.disprot.org/protein.php?id=DP00400 EC_number EC:3.6.3.- {ECO:0000255|HAMAP-Rule:MF_01703, ECO:0000305} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.- {ECO:0000255|HAMAP-Rule:MF_01703, ECO:0000305} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL Z11796 http://www.ebi.ac.uk/ena/data/view/Z11796 ENZYME 3.6.3.- {ECO:0000255|HAMAP-Rule:MF_01703, ECO:0000305} http://enzyme.expasy.org/EC/3.6.3.- {ECO:0000255|HAMAP-Rule:MF_01703, ECO:0000305} EchoBASE EB0608 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0608 EcoGene EG10613 http://www.ecogene.org/geneInfo.php?eg_id=EG10613 EnsemblBacteria AAC74000 http://www.ensemblgenomes.org/id/AAC74000 EnsemblBacteria AAC74000 http://www.ensemblgenomes.org/id/AAC74000 EnsemblBacteria BAA35658 http://www.ensemblgenomes.org/id/BAA35658 EnsemblBacteria BAA35658 http://www.ensemblgenomes.org/id/BAA35658 EnsemblBacteria BAA35658 http://www.ensemblgenomes.org/id/BAA35658 EnsemblBacteria b0914 http://www.ensemblgenomes.org/id/b0914 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0005319 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005319 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008144 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008144 GO_function GO:0008289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289 GO_function GO:0015437 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015437 GO_function GO:0034040 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034040 GO_process GO:0006869 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006869 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945530 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945530 InParanoid P60752 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P60752 IntAct P60752 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P60752* IntEnz 3.6.3.- {ECO:0000255|HAMAP-Rule:MF_01703, ECO:0000305} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.- {ECO:0000255|HAMAP-Rule:MF_01703, ECO:0000305} InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR011527 http://www.ebi.ac.uk/interpro/entry/IPR011527 InterPro IPR011917 http://www.ebi.ac.uk/interpro/entry/IPR011917 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0897 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0897 KEGG_Gene eco:b0914 http://www.genome.jp/dbget-bin/www_bget?eco:b0914 KEGG_Orthology KO:K11085 http://www.genome.jp/dbget-bin/www_bget?KO:K11085 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 MINT MINT-1277336 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1277336 OMA ENCAVVS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ENCAVVS PDB 3B5W http://www.ebi.ac.uk/pdbe-srv/view/entry/3B5W PDBsum 3B5W http://www.ebi.ac.uk/pdbsum/3B5W PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PROSITE PS50929 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50929 PROSITE PS51239 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51239 PSORT swissprot:MSBA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MSBA_ECOLI PSORT-B swissprot:MSBA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MSBA_ECOLI PSORT2 swissprot:MSBA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MSBA_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Pfam PF00664 http://pfam.xfam.org/family/PF00664 Phobius swissprot:MSBA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MSBA_ECOLI PhylomeDB P60752 http://phylomedb.org/?seqid=P60752 ProteinModelPortal P60752 http://www.proteinmodelportal.org/query/uniprot/P60752 PubMed 11278265 http://www.ncbi.nlm.nih.gov/pubmed/11278265 PubMed 11546864 http://www.ncbi.nlm.nih.gov/pubmed/11546864 PubMed 12119303 http://www.ncbi.nlm.nih.gov/pubmed/12119303 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17185584 http://www.ncbi.nlm.nih.gov/pubmed/17185584 PubMed 8094880 http://www.ncbi.nlm.nih.gov/pubmed/8094880 PubMed 8809774 http://www.ncbi.nlm.nih.gov/pubmed/8809774 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9575204 http://www.ncbi.nlm.nih.gov/pubmed/9575204 RefSeq NP_415434 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415434 RefSeq WP_000551270 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000551270 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P60752 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P60752 STRING 511145.b0914 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0914&targetmode=cogs STRING COG1132 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1132&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SUPFAM SSF90123 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90123 TCDB 3.A.1.106 http://www.tcdb.org/search/result.php?tc=3.A.1.106 TIGRFAMs TIGR02203 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02203 UniProtKB MSBA_ECOLI http://www.uniprot.org/uniprot/MSBA_ECOLI UniProtKB-AC P60752 http://www.uniprot.org/uniprot/P60752 charge swissprot:MSBA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MSBA_ECOLI eggNOG COG1132 http://eggnogapi.embl.de/nog_data/html/tree/COG1132 eggNOG ENOG4105BZ1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZ1 epestfind swissprot:MSBA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MSBA_ECOLI garnier swissprot:MSBA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MSBA_ECOLI helixturnhelix swissprot:MSBA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MSBA_ECOLI hmoment swissprot:MSBA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MSBA_ECOLI iep swissprot:MSBA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MSBA_ECOLI inforesidue swissprot:MSBA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MSBA_ECOLI octanol swissprot:MSBA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MSBA_ECOLI pepcoil swissprot:MSBA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MSBA_ECOLI pepdigest swissprot:MSBA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MSBA_ECOLI pepinfo swissprot:MSBA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MSBA_ECOLI pepnet swissprot:MSBA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MSBA_ECOLI pepstats swissprot:MSBA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MSBA_ECOLI pepwheel swissprot:MSBA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MSBA_ECOLI pepwindow swissprot:MSBA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MSBA_ECOLI sigcleave swissprot:MSBA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MSBA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261725 12 # EcoGene EG12932 yhgF # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003723 RNA binding; IEA:UniProtKB-KW. # GO_process GO:0006139 nucleobase-containing compound metabolic process; IEA:InterPro. # GO_process GO:0010212 response to ionizing radiation; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.650 -; 1. # Gene3D 1.10.150.310 -; 1. # Gene3D 1.10.3500.10 -; 2. # Gene3D 3.30.420.140 -; 1. # IntAct P46837 9 # InterPro IPR003029 S1_domain # InterPro IPR006641 YqgF/RNaseH-like_dom # InterPro IPR010994 RuvA_2-like # InterPro IPR012337 RNaseH-like_dom # InterPro IPR012340 NA-bd_OB-fold # InterPro IPR018974 Tex-like_N # InterPro IPR022967 S1_dom # InterPro IPR023097 Tex_RuvX-like_dom # InterPro IPR023319 Tex-like_HTH_dom # InterPro IPR023323 Tex-like_dom # InterPro IPR032639 Tex_YqgF # Organism YHGF_ECOLI Escherichia coli (strain K12) # PATRIC 32122250 VBIEscCol129921_3502 # PIR B65136 B65136 # PROSITE PS50126 S1 # Pfam PF00575 S1 # Pfam PF09371 Tex_N # Pfam PF16921 Tex_YqgF # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHGF_ECOLI Protein YhgF # RefSeq NP_417866 NC_000913.3 # RefSeq WP_000980727 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA58204.1; Type=Miscellaneous discrepancy; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=AAA58205.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=AAA58205.1; Type=Frameshift; Positions=12, 66; Evidence={ECO:0000305}; # SIMILARITY Contains 1 S1 motif domain. {ECO:0000255|PROSITE- ProRule PRU00180}. # SMART SM00316 S1 # SMART SM00732 YqgFc # SUPFAM SSF47781 SSF47781; 2 # SUPFAM SSF50249 SSF50249 # SUPFAM SSF53098 SSF53098 # eggNOG COG2183 LUCA # eggNOG ENOG4105BZM Bacteria BLAST swissprot:YHGF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHGF_ECOLI BioCyc ECOL316407:JW3370-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3370-MONOMER BioCyc EcoCyc:G7746-MONOMER http://biocyc.org/getid?id=EcoCyc:G7746-MONOMER COG COG2183 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2183 DIP DIP-12337N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12337N DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2768 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2768 EcoGene EG12932 http://www.ecogene.org/geneInfo.php?eg_id=EG12932 EnsemblBacteria AAC76432 http://www.ensemblgenomes.org/id/AAC76432 EnsemblBacteria AAC76432 http://www.ensemblgenomes.org/id/AAC76432 EnsemblBacteria BAE77884 http://www.ensemblgenomes.org/id/BAE77884 EnsemblBacteria BAE77884 http://www.ensemblgenomes.org/id/BAE77884 EnsemblBacteria BAE77884 http://www.ensemblgenomes.org/id/BAE77884 EnsemblBacteria b3407 http://www.ensemblgenomes.org/id/b3407 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_process GO:0006139 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006139 GO_process GO:0010212 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010212 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.650 http://www.cathdb.info/version/latest/superfamily/1.10.10.650 Gene3D 1.10.150.310 http://www.cathdb.info/version/latest/superfamily/1.10.150.310 Gene3D 1.10.3500.10 http://www.cathdb.info/version/latest/superfamily/1.10.3500.10 Gene3D 3.30.420.140 http://www.cathdb.info/version/latest/superfamily/3.30.420.140 GeneID 947911 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947911 HOGENOM HOG000270497 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000270497&db=HOGENOM6 InParanoid P46837 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P46837 IntAct P46837 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P46837* InterPro IPR003029 http://www.ebi.ac.uk/interpro/entry/IPR003029 InterPro IPR006641 http://www.ebi.ac.uk/interpro/entry/IPR006641 InterPro IPR010994 http://www.ebi.ac.uk/interpro/entry/IPR010994 InterPro IPR012337 http://www.ebi.ac.uk/interpro/entry/IPR012337 InterPro IPR012340 http://www.ebi.ac.uk/interpro/entry/IPR012340 InterPro IPR018974 http://www.ebi.ac.uk/interpro/entry/IPR018974 InterPro IPR022967 http://www.ebi.ac.uk/interpro/entry/IPR022967 InterPro IPR023097 http://www.ebi.ac.uk/interpro/entry/IPR023097 InterPro IPR023319 http://www.ebi.ac.uk/interpro/entry/IPR023319 InterPro IPR023323 http://www.ebi.ac.uk/interpro/entry/IPR023323 InterPro IPR032639 http://www.ebi.ac.uk/interpro/entry/IPR032639 KEGG_Gene ecj:JW3370 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3370 KEGG_Gene eco:b3407 http://www.genome.jp/dbget-bin/www_bget?eco:b3407 KEGG_Orthology KO:K06959 http://www.genome.jp/dbget-bin/www_bget?KO:K06959 MINT MINT-1288997 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1288997 OMA RWTWKVK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RWTWKVK PROSITE PS50126 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50126 PSORT swissprot:YHGF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHGF_ECOLI PSORT-B swissprot:YHGF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHGF_ECOLI PSORT2 swissprot:YHGF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHGF_ECOLI Pfam PF00575 http://pfam.xfam.org/family/PF00575 Pfam PF09371 http://pfam.xfam.org/family/PF09371 Pfam PF16921 http://pfam.xfam.org/family/PF16921 Phobius swissprot:YHGF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHGF_ECOLI PhylomeDB P46837 http://phylomedb.org/?seqid=P46837 ProteinModelPortal P46837 http://www.proteinmodelportal.org/query/uniprot/P46837 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417866 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417866 RefSeq WP_000980727 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000980727 SMART SM00316 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00316 SMART SM00732 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00732 SMR P46837 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P46837 STRING 511145.b3407 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3407&targetmode=cogs STRING COG2183 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2183&targetmode=cogs SUPFAM SSF47781 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47781 SUPFAM SSF50249 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50249 SUPFAM SSF53098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098 UniProtKB YHGF_ECOLI http://www.uniprot.org/uniprot/YHGF_ECOLI UniProtKB-AC P46837 http://www.uniprot.org/uniprot/P46837 charge swissprot:YHGF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHGF_ECOLI eggNOG COG2183 http://eggnogapi.embl.de/nog_data/html/tree/COG2183 eggNOG ENOG4105BZM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZM epestfind swissprot:YHGF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHGF_ECOLI garnier swissprot:YHGF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHGF_ECOLI helixturnhelix swissprot:YHGF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHGF_ECOLI hmoment swissprot:YHGF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHGF_ECOLI iep swissprot:YHGF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHGF_ECOLI inforesidue swissprot:YHGF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHGF_ECOLI octanol swissprot:YHGF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHGF_ECOLI pepcoil swissprot:YHGF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHGF_ECOLI pepdigest swissprot:YHGF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHGF_ECOLI pepinfo swissprot:YHGF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHGF_ECOLI pepnet swissprot:YHGF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHGF_ECOLI pepstats swissprot:YHGF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHGF_ECOLI pepwheel swissprot:YHGF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHGF_ECOLI pepwindow swissprot:YHGF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHGF_ECOLI sigcleave swissprot:YHGF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHGF_ECOLI ## Database ID URL or Descriptions # AltName AHR_ECOLI Zinc-dependent alcohol dehydrogenase Ahr # BIOPHYSICOCHEMICAL PROPERTIES AHR_ECOLI Kinetic parameters KM=73.4 mM for acetaldehyde {ECO 0000269|PubMed 23093176}; KM=19.6 mM for propionaldehyde {ECO 0000269|PubMed 23093176}; KM=2.1 mM for butyraldehyde {ECO 0000269|PubMed 23093176}; KM=193.7 mM for isobutyraldehyde {ECO 0000269|PubMed 23093176}; KM=2.4 mM for crotonaldehyde {ECO 0000269|PubMed 23093176}; KM=5.8 mM for glutaraldehyde {ECO 0000269|PubMed 23093176}; KM=59.7 mM for 5-hydroxyvalerate {ECO 0000269|PubMed 23093176}; KM=0.34 mM for hexanaldehyde {ECO 0000269|PubMed 23093176}; KM=0.24 mM for benzaldehyde {ECO 0000269|PubMed 23093176}; KM=0.22 mM for furfural {ECO 0000269|PubMed 23093176}; KM=3.5 mM for butanol {ECO 0000269|PubMed 23093176}; KM=24.1 mM for 1,4-butanediol {ECO 0000269|PubMed 23093176}; KM=0.06 mM for NADPH {ECO 0000269|PubMed 23093176}; KM=0.076 mM for NADP(+) {ECO 0000269|PubMed 23093176}; Note=kcat is 333 sec(-1) for acetaldehyde reduction. kcat is 207 sec(-1) for propionaldehyde reduction. kcat is 464 sec(-1) for butyraldehyde reduction. kcat is 51 sec(-1) for isobutyraldehyde reduction. kcat is 78 sec(-1) for crotonaldehyde reduction. kcat is 312 sec(-1) for glutaraldehyde reduction. kcat is 2.6 sec(-1) for 5-hydroxyvalerate reduction. kcat is 419 sec(-1) for hexanaldehyde reduction. kcat is 313 sec(-1) for benzaldehyde reduction. kcat is 224 sec(-1) for furfural reduction. kcat is 13.8 sec(-1) for butanol oxidation. kcat is 12.9 sec(-1) for 1,4-butanediol oxidation.; Temperature dependence Optimum temperature is 37-50 degrees Celsius using butyraldehyde as substrate. {ECO 0000269|PubMed 23093176}; # BIOTECHNOLOGY This enzyme can be applied to the microbial production of fatty alcohols that have numerous applications as fuels, fragrances, emollients, food additives, and detergents. Thus, together with complementing enzymes, the broad substrate specificity of Ahr opens the road for direct and tailored enzyme- catalyzed conversion of lipids into user-ready chemical commodities. {ECO:0000269|PubMed 23248280}. # BioGrid 4263049 5 # CATALYTIC ACTIVITY AHR_ECOLI An alcohol + NADP(+) = an aldehyde + NADPH. {ECO 0000269|PubMed 23093176, ECO 0000269|PubMed 23248280}. # COFACTOR AHR_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000305|PubMed 22094925}; Note=Binds 2 Zn(2+) ions per subunit. {ECO 0000305|PubMed 22094925}; # EcoGene EG11436 ahr # FUNCTION AHR_ECOLI Catalyzes the reduction of a wide range of aldehydes including aliphatic fatty aldehydes (C4-C16), into their corresponding alcohols. Has a strong preference for NADPH over NADH as the electron donor. Cannot use glyceraldehyde or a ketone as substrate. Is a relevant source of NADPH-dependent aldehyde reductase activity in E.coli. The in vivo functions of Ahr has yet to be determined. {ECO 0000269|PubMed 22731523, ECO 0000269|PubMed 23093176, ECO 0000269|PubMed 23248280}. # GO_function GO:0008106 alcohol dehydrogenase (NADP+) activity; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_process GO:0006631 fatty acid metabolic process; IEA:UniProtKB-KW. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.720 -; 1. # Gene3D 3.90.180.10 -; 1. # InterPro IPR002085 ADH_SF_Zn-type # InterPro IPR002328 ADH_Zn_CS # InterPro IPR011032 GroES-like # InterPro IPR013149 ADH_C # InterPro IPR013154 ADH_N # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR020843 PKS_ER # InterPro IPR029752 D-isomer_DH_CS1 # KEGG_Brite ko01000 Enzymes # Organism AHR_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11695 PTHR11695 # PATRIC 32124111 VBIEscCol129921_4400 # PIR S56495 S56495 # PROSITE PS00059 ADH_ZINC # Pfam PF00107 ADH_zinc_N # Pfam PF08240 ADH_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AHR_ECOLI Aldehyde reductase Ahr # RefSeq NP_418690 NC_000913.3 # RefSeq WP_001309160 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97166.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the zinc-containing alcohol dehydrogenase family. {ECO 0000305}. # SMART SM00829 PKS_ER # SUPFAM SSF50129 SSF50129 # SUPFAM SSF51735 SSF51735 # eggNOG COG1064 LUCA # eggNOG ENOG4105DQ4 Bacteria BLAST swissprot:AHR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AHR_ECOLI BioCyc ECOL316407:JW5761-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5761-MONOMER BioCyc EcoCyc:EG11436-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11436-MONOMER BioCyc MetaCyc:EG11436-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11436-MONOMER COG COG1064 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1064 DOI 10.1007/s00253-012-4474-5 http://dx.doi.org/10.1007/s00253-012-4474-5 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1039/c1mt00154j http://dx.doi.org/10.1039/c1mt00154j DOI 10.1073/pnas.1216516110 http://dx.doi.org/10.1073/pnas.1216516110 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1186/1475-2859-11-90 http://dx.doi.org/10.1186/1475-2859-11-90 EC_number EC:1.1.1.2 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M96355 http://www.ebi.ac.uk/ena/data/view/M96355 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 1.1.1.2 http://enzyme.expasy.org/EC/1.1.1.2 EchoBASE EB1406 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1406 EcoGene EG11436 http://www.ecogene.org/geneInfo.php?eg_id=EG11436 EnsemblBacteria AAC77226 http://www.ensemblgenomes.org/id/AAC77226 EnsemblBacteria AAC77226 http://www.ensemblgenomes.org/id/AAC77226 EnsemblBacteria BAE78266 http://www.ensemblgenomes.org/id/BAE78266 EnsemblBacteria BAE78266 http://www.ensemblgenomes.org/id/BAE78266 EnsemblBacteria BAE78266 http://www.ensemblgenomes.org/id/BAE78266 EnsemblBacteria b4269 http://www.ensemblgenomes.org/id/b4269 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008106 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008106 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_process GO:0006631 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006631 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 Gene3D 3.90.180.10 http://www.cathdb.info/version/latest/superfamily/3.90.180.10 GeneID 948802 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948802 HOGENOM HOG000294667 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000294667&db=HOGENOM6 InParanoid P27250 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P27250 IntEnz 1.1.1.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.2 InterPro IPR002085 http://www.ebi.ac.uk/interpro/entry/IPR002085 InterPro IPR002328 http://www.ebi.ac.uk/interpro/entry/IPR002328 InterPro IPR011032 http://www.ebi.ac.uk/interpro/entry/IPR011032 InterPro IPR013149 http://www.ebi.ac.uk/interpro/entry/IPR013149 InterPro IPR013154 http://www.ebi.ac.uk/interpro/entry/IPR013154 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR020843 http://www.ebi.ac.uk/interpro/entry/IPR020843 InterPro IPR029752 http://www.ebi.ac.uk/interpro/entry/IPR029752 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5761 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5761 KEGG_Gene eco:b4269 http://www.genome.jp/dbget-bin/www_bget?eco:b4269 KEGG_Orthology KO:K12957 http://www.genome.jp/dbget-bin/www_bget?KO:K12957 OMA CAQAEST http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CAQAEST PANTHER PTHR11695 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11695 PROSITE PS00059 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00059 PSORT swissprot:AHR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AHR_ECOLI PSORT-B swissprot:AHR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AHR_ECOLI PSORT2 swissprot:AHR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AHR_ECOLI Pfam PF00107 http://pfam.xfam.org/family/PF00107 Pfam PF08240 http://pfam.xfam.org/family/PF08240 Phobius swissprot:AHR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AHR_ECOLI PhylomeDB P27250 http://phylomedb.org/?seqid=P27250 ProteinModelPortal P27250 http://www.proteinmodelportal.org/query/uniprot/P27250 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22094925 http://www.ncbi.nlm.nih.gov/pubmed/22094925 PubMed 22731523 http://www.ncbi.nlm.nih.gov/pubmed/22731523 PubMed 23093176 http://www.ncbi.nlm.nih.gov/pubmed/23093176 PubMed 23248280 http://www.ncbi.nlm.nih.gov/pubmed/23248280 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418690 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418690 RefSeq WP_001309160 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001309160 SMART SM00829 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00829 SMR P27250 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P27250 STRING 511145.b4269 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4269&targetmode=cogs STRING COG1064 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1064&targetmode=cogs SUPFAM SSF50129 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50129 SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB AHR_ECOLI http://www.uniprot.org/uniprot/AHR_ECOLI UniProtKB-AC P27250 http://www.uniprot.org/uniprot/P27250 charge swissprot:AHR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AHR_ECOLI eggNOG COG1064 http://eggnogapi.embl.de/nog_data/html/tree/COG1064 eggNOG ENOG4105DQ4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DQ4 epestfind swissprot:AHR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AHR_ECOLI garnier swissprot:AHR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AHR_ECOLI helixturnhelix swissprot:AHR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AHR_ECOLI hmoment swissprot:AHR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AHR_ECOLI iep swissprot:AHR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AHR_ECOLI inforesidue swissprot:AHR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AHR_ECOLI octanol swissprot:AHR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AHR_ECOLI pepcoil swissprot:AHR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AHR_ECOLI pepdigest swissprot:AHR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AHR_ECOLI pepinfo swissprot:AHR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AHR_ECOLI pepnet swissprot:AHR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AHR_ECOLI pepstats swissprot:AHR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AHR_ECOLI pepwheel swissprot:AHR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AHR_ECOLI pepwindow swissprot:AHR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AHR_ECOLI sigcleave swissprot:AHR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AHR_ECOLI ## Database ID URL or Descriptions # BioGrid 4259687 312 # CAZy GT2 Glycosyltransferase Family 2 # EcoGene EG13569 wcaA # GO_function GO:0016757 transferase activity, transferring glycosyl groups; IBA:GO_Central. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0045228 slime layer polysaccharide biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.90.550.10 -; 1. # IntAct P77414 8 # InterPro IPR001173 Glyco_trans_2-like # InterPro IPR024009 Colanic_acid_synth_WcaA # InterPro IPR029044 Nucleotide-diphossugar_trans # Organism WCAA_ECOLI Escherichia coli (strain K12) # PATHWAY WCAA_ECOLI Slime biogenesis; slime polysaccharide biosynthesis. # PATRIC 32119451 VBIEscCol129921_2136 # PIR B64972 B64972 # Pfam PF00535 Glycos_transf_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName WCAA_ECOLI Putative colanic acid biosynthesis glycosyl transferase WcaA # RefSeq NP_416563 NC_000913.3 # RefSeq WP_000794699 NZ_LN832404.1 # SIMILARITY To R.meliloti ExoO. {ECO 0000305}. # SUPFAM SSF53448 SSF53448 # TIGRFAMs TIGR04017 WcaA # eggNOG COG0463 LUCA # eggNOG ENOG41090RK Bacteria BLAST swissprot:WCAA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:WCAA_ECOLI BioCyc ECOL316407:JW2044-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2044-MONOMER BioCyc EcoCyc:G7104-MONOMER http://biocyc.org/getid?id=EcoCyc:G7104-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U38473 http://www.ebi.ac.uk/ena/data/view/U38473 EchoBASE EB3339 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3339 EcoGene EG13569 http://www.ecogene.org/geneInfo.php?eg_id=EG13569 EnsemblBacteria AAC75120 http://www.ensemblgenomes.org/id/AAC75120 EnsemblBacteria AAC75120 http://www.ensemblgenomes.org/id/AAC75120 EnsemblBacteria BAA15912 http://www.ensemblgenomes.org/id/BAA15912 EnsemblBacteria BAA15912 http://www.ensemblgenomes.org/id/BAA15912 EnsemblBacteria BAA15912 http://www.ensemblgenomes.org/id/BAA15912 EnsemblBacteria b2059 http://www.ensemblgenomes.org/id/b2059 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GO_process GO:0045228 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045228 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.90.550.10 http://www.cathdb.info/version/latest/superfamily/3.90.550.10 GeneID 946570 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946570 HOGENOM HOG000121977 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000121977&db=HOGENOM6 InParanoid P77414 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77414 IntAct P77414 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77414* InterPro IPR001173 http://www.ebi.ac.uk/interpro/entry/IPR001173 InterPro IPR024009 http://www.ebi.ac.uk/interpro/entry/IPR024009 InterPro IPR029044 http://www.ebi.ac.uk/interpro/entry/IPR029044 KEGG_Gene ecj:JW2044 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2044 KEGG_Gene eco:b2059 http://www.genome.jp/dbget-bin/www_bget?eco:b2059 OMA THNAINS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=THNAINS PSORT swissprot:WCAA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:WCAA_ECOLI PSORT-B swissprot:WCAA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:WCAA_ECOLI PSORT2 swissprot:WCAA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:WCAA_ECOLI Pfam PF00535 http://pfam.xfam.org/family/PF00535 Phobius swissprot:WCAA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:WCAA_ECOLI PhylomeDB P77414 http://phylomedb.org/?seqid=P77414 ProteinModelPortal P77414 http://www.proteinmodelportal.org/query/uniprot/P77414 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8759852 http://www.ncbi.nlm.nih.gov/pubmed/8759852 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416563 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416563 RefSeq WP_000794699 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000794699 SMR P77414 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77414 STRING 511145.b2059 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2059&targetmode=cogs SUPFAM SSF53448 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53448 TIGRFAMs TIGR04017 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR04017 UniProtKB WCAA_ECOLI http://www.uniprot.org/uniprot/WCAA_ECOLI UniProtKB-AC P77414 http://www.uniprot.org/uniprot/P77414 charge swissprot:WCAA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:WCAA_ECOLI eggNOG COG0463 http://eggnogapi.embl.de/nog_data/html/tree/COG0463 eggNOG ENOG41090RK http://eggnogapi.embl.de/nog_data/html/tree/ENOG41090RK epestfind swissprot:WCAA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:WCAA_ECOLI garnier swissprot:WCAA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:WCAA_ECOLI helixturnhelix swissprot:WCAA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:WCAA_ECOLI hmoment swissprot:WCAA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:WCAA_ECOLI iep swissprot:WCAA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:WCAA_ECOLI inforesidue swissprot:WCAA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:WCAA_ECOLI octanol swissprot:WCAA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:WCAA_ECOLI pepcoil swissprot:WCAA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:WCAA_ECOLI pepdigest swissprot:WCAA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:WCAA_ECOLI pepinfo swissprot:WCAA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:WCAA_ECOLI pepnet swissprot:WCAA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:WCAA_ECOLI pepstats swissprot:WCAA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:WCAA_ECOLI pepwheel swissprot:WCAA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:WCAA_ECOLI pepwindow swissprot:WCAA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:WCAA_ECOLI sigcleave swissprot:WCAA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:WCAA_ECOLI ## Database ID URL or Descriptions # AltName ATP phosphohydrolase [potassium-transporting] F chain {ECO 0000305} # AltName Potassium-binding and translocating subunit F {ECO 0000305} # AltName Potassium-translocating ATPase F chain {ECO 0000305} # BioGrid 4259926 3 # DISRUPTION PHENOTYPE Inactivation of kdpF still leads to a functional KdpABC complex in vivo. Deletion impairs ATPase activity of the complex in vitro. {ECO:0000269|PubMed 10608856}. # EcoGene EG12126 kdpF # FUNCTION KDPF_ECOLI Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm (PubMed 23930894). This subunit may be involved in stabilization of the complex (PubMed 10608856). {ECO 0000269|PubMed 10608856, ECO 0000269|PubMed 23930894}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0008556 potassium-transporting ATPase activity; IMP:EcoCyc. # GO_process GO:0043462 regulation of ATPase activity; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0008150 biological_process # INDUCTION Transcriptionally regulated by the KdpD/KdpE two- component regulatory system. {ECO:0000269|PubMed 1532387}. # InterPro IPR011726 KdpF # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko02020 Two-component system # Organism KDPF_ECOLI Escherichia coli (strain K12) # PATRIC 32116593 VBIEscCol129921_0729 # PIR T48910 T48910 # Pfam PF09604 Potass_KdpF # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Potassium-transporting ATPase KdpF subunit {ECO 0000305} # RefSeq WP_001272653 NZ_LN832404.1 # RefSeq YP_588443 NC_000913.3 # SIMILARITY Belongs to the KdpF family. {ECO 0000305}. # SUBCELLULAR LOCATION KDPF_ECOLI Cell inner membrane {ECO 0000305|PubMed 10608856}; Single-pass membrane protein {ECO 0000255}. # SUBUNIT KDPF_ECOLI The system is composed of three essential subunits KdpA, KdpB and KdpC (PubMed 10608856). The complex also contains KdpF, a small non-essential subunit (PubMed 10608856). The KdpFABC complex exists as a dimer above concentrations of 30-50 nM, whereas the complex exists as a functional monomer at lower concentrations (PubMed 18298081). {ECO 0000269|PubMed 10608856, ECO 0000269|PubMed 18298081}. # TCDB 3.A.3.7 the p-type atpase (p-atpase) superfamily # TIGRFAMs TIGR02115 potass_kdpF BLAST swissprot:KDPF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:KDPF_ECOLI BioCyc ECOL316407:JW0687-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0687-MONOMER BioCyc EcoCyc:MONOMER0-12 http://biocyc.org/getid?id=EcoCyc:MONOMER0-12 BioCyc MetaCyc:MONOMER0-12 http://biocyc.org/getid?id=MetaCyc:MONOMER0-12 DOI 10.1021/bi400729e http://dx.doi.org/10.1021/bi400729e DOI 10.1021/bi702038e http://dx.doi.org/10.1021/bi702038e DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.81.15.4746 http://dx.doi.org/10.1073/pnas.81.15.4746 DOI 10.1074/jbc.274.53.37901 http://dx.doi.org/10.1074/jbc.274.53.37901 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1749-6632.1992.tb43799.x http://dx.doi.org/10.1111/j.1749-6632.1992.tb43799.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K02670 http://www.ebi.ac.uk/ena/data/view/K02670 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2047 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2047 EcoGene EG12126 http://www.ecogene.org/geneInfo.php?eg_id=EG12126 EnsemblBacteria ABD18643 http://www.ensemblgenomes.org/id/ABD18643 EnsemblBacteria ABD18643 http://www.ensemblgenomes.org/id/ABD18643 EnsemblBacteria BAA35357 http://www.ensemblgenomes.org/id/BAA35357 EnsemblBacteria BAA35357 http://www.ensemblgenomes.org/id/BAA35357 EnsemblBacteria BAA35357 http://www.ensemblgenomes.org/id/BAA35357 EnsemblBacteria b4513 http://www.ensemblgenomes.org/id/b4513 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008556 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008556 GO_process GO:0043462 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043462 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 948946 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948946 InterPro IPR011726 http://www.ebi.ac.uk/interpro/entry/IPR011726 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW0687 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0687 KEGG_Gene eco:b4513 http://www.genome.jp/dbget-bin/www_bget?eco:b4513 KEGG_Orthology KO:K01545 http://www.genome.jp/dbget-bin/www_bget?KO:K01545 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 PSORT swissprot:KDPF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:KDPF_ECOLI PSORT-B swissprot:KDPF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:KDPF_ECOLI PSORT2 swissprot:KDPF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:KDPF_ECOLI Pfam PF09604 http://pfam.xfam.org/family/PF09604 Phobius swissprot:KDPF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:KDPF_ECOLI PubMed 10608856 http://www.ncbi.nlm.nih.gov/pubmed/10608856 PubMed 1288322 http://www.ncbi.nlm.nih.gov/pubmed/1288322 PubMed 1532387 http://www.ncbi.nlm.nih.gov/pubmed/1532387 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18298081 http://www.ncbi.nlm.nih.gov/pubmed/18298081 PubMed 23930894 http://www.ncbi.nlm.nih.gov/pubmed/23930894 PubMed 6146979 http://www.ncbi.nlm.nih.gov/pubmed/6146979 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001272653 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001272653 RefSeq YP_588443 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_588443 STRING 511145.b4513 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4513&targetmode=cogs TCDB 3.A.3.7 http://www.tcdb.org/search/result.php?tc=3.A.3.7 TIGRFAMs TIGR02115 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02115 UniProtKB KDPF_ECOLI http://www.uniprot.org/uniprot/KDPF_ECOLI UniProtKB-AC P36937 http://www.uniprot.org/uniprot/P36937 charge swissprot:KDPF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:KDPF_ECOLI epestfind swissprot:KDPF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:KDPF_ECOLI garnier swissprot:KDPF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:KDPF_ECOLI helixturnhelix swissprot:KDPF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:KDPF_ECOLI hmoment swissprot:KDPF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:KDPF_ECOLI iep swissprot:KDPF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:KDPF_ECOLI inforesidue swissprot:KDPF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:KDPF_ECOLI octanol swissprot:KDPF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:KDPF_ECOLI pepcoil swissprot:KDPF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:KDPF_ECOLI pepdigest swissprot:KDPF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:KDPF_ECOLI pepinfo swissprot:KDPF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:KDPF_ECOLI pepnet swissprot:KDPF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:KDPF_ECOLI pepstats swissprot:KDPF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:KDPF_ECOLI pepwheel swissprot:KDPF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:KDPF_ECOLI pepwindow swissprot:KDPF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:KDPF_ECOLI sigcleave swissprot:KDPF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:KDPF_ECOLI ## Database ID URL or Descriptions # BioGrid 4261829 196 # EcoGene EG11011 tolR # FUNCTION TOLR_ECOLI Involved in the TonB-independent uptake of group A colicins (colicins A, E1, E2, E3, and K). # GO_component GO:0005886 plasma membrane; IDA:EcoliWiki. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IDA:EcoliWiki. # GO_component GO:0032153 cell division site; IDA:EcoCyc. # GO_function GO:0005215 transporter activity; IEA:InterPro. # GO_process GO:0015031 protein transport; IEA:UniProtKB-KW. # GO_process GO:0043213 bacteriocin transport; IMP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006810 transport # IntAct P0ABV6 2 # InterPro IPR003400 ExbD # InterPro IPR014168 Biopolymer_transpt_TolR # KEGG_Brite ko02000 Transporters # Organism TOLR_ECOLI Escherichia coli (strain K12) # PATRIC 32116675 VBIEscCol129921_0770 # PDB 5BY4 X-ray; 1.70 A; A=36-142 # PIR C25980 BVECTR # Pfam PF02472 ExbD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TOLR_ECOLI Protein TolR # RefSeq NP_415266 NC_000913.3 # RefSeq WP_000090097 NZ_LN832404.1 # SIMILARITY Belongs to the ExbD/TolR family. {ECO 0000305}. # SUBCELLULAR LOCATION TOLR_ECOLI Cell inner membrane; Single-pass type II membrane protein. # TIGRFAMs TIGR02801 tolR # eggNOG COG0848 LUCA BLAST swissprot:TOLR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TOLR_ECOLI BioCyc ECOL316407:JW0728-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0728-MONOMER BioCyc EcoCyc:EG11011-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11011-MONOMER COG COG0848 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0848 DIP DIP-48143N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48143N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M16489 http://www.ebi.ac.uk/ena/data/view/M16489 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1004 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1004 EcoGene EG11011 http://www.ecogene.org/geneInfo.php?eg_id=EG11011 EnsemblBacteria AAC73832 http://www.ensemblgenomes.org/id/AAC73832 EnsemblBacteria AAC73832 http://www.ensemblgenomes.org/id/AAC73832 EnsemblBacteria BAA35404 http://www.ensemblgenomes.org/id/BAA35404 EnsemblBacteria BAA35404 http://www.ensemblgenomes.org/id/BAA35404 EnsemblBacteria BAA35404 http://www.ensemblgenomes.org/id/BAA35404 EnsemblBacteria b0738 http://www.ensemblgenomes.org/id/b0738 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0032153 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032153 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_process GO:0015031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031 GO_process GO:0043213 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043213 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 945328 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945328 HOGENOM HOG000134906 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000134906&db=HOGENOM6 InParanoid P0ABV6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABV6 IntAct P0ABV6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABV6* InterPro IPR003400 http://www.ebi.ac.uk/interpro/entry/IPR003400 InterPro IPR014168 http://www.ebi.ac.uk/interpro/entry/IPR014168 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0728 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0728 KEGG_Gene eco:b0738 http://www.genome.jp/dbget-bin/www_bget?eco:b0738 KEGG_Orthology KO:K03560 http://www.genome.jp/dbget-bin/www_bget?KO:K03560 OMA PLITHGV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PLITHGV PDB 5BY4 http://www.ebi.ac.uk/pdbe-srv/view/entry/5BY4 PDBsum 5BY4 http://www.ebi.ac.uk/pdbsum/5BY4 PSORT swissprot:TOLR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TOLR_ECOLI PSORT-B swissprot:TOLR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TOLR_ECOLI PSORT2 swissprot:TOLR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TOLR_ECOLI Pfam PF02472 http://pfam.xfam.org/family/PF02472 Phobius swissprot:TOLR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TOLR_ECOLI PhylomeDB P0ABV6 http://phylomedb.org/?seqid=P0ABV6 ProteinModelPortal P0ABV6 http://www.proteinmodelportal.org/query/uniprot/P0ABV6 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3294803 http://www.ncbi.nlm.nih.gov/pubmed/3294803 PubMed 8331075 http://www.ncbi.nlm.nih.gov/pubmed/8331075 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415266 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415266 RefSeq WP_000090097 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000090097 SMR P0ABV6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABV6 STRING 511145.b0738 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0738&targetmode=cogs STRING COG0848 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0848&targetmode=cogs TIGRFAMs TIGR02801 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02801 UniProtKB TOLR_ECOLI http://www.uniprot.org/uniprot/TOLR_ECOLI UniProtKB-AC P0ABV6 http://www.uniprot.org/uniprot/P0ABV6 charge swissprot:TOLR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TOLR_ECOLI eggNOG COG0848 http://eggnogapi.embl.de/nog_data/html/tree/COG0848 epestfind swissprot:TOLR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TOLR_ECOLI garnier swissprot:TOLR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TOLR_ECOLI helixturnhelix swissprot:TOLR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TOLR_ECOLI hmoment swissprot:TOLR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TOLR_ECOLI iep swissprot:TOLR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TOLR_ECOLI inforesidue swissprot:TOLR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TOLR_ECOLI octanol swissprot:TOLR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TOLR_ECOLI pepcoil swissprot:TOLR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TOLR_ECOLI pepdigest swissprot:TOLR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TOLR_ECOLI pepinfo swissprot:TOLR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TOLR_ECOLI pepnet swissprot:TOLR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TOLR_ECOLI pepstats swissprot:TOLR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TOLR_ECOLI pepwheel swissprot:TOLR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TOLR_ECOLI pepwindow swissprot:TOLR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TOLR_ECOLI sigcleave swissprot:TOLR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TOLR_ECOLI ## Database ID URL or Descriptions # AltName LPPY_ECOLI PyrBI operon attenuator # BioGrid 4262947 11 # EcoGene EG11279 pyrL # GO_process GO:0006221 pyrimidine nucleotide biosynthetic process; IMP:EcoCyc. # GO_process GO:0019856 pyrimidine nucleobase biosynthetic process; IMP:EcoCyc. # GO_process GO:0031555 transcriptional attenuation; IMP:EcoCyc. # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # InterPro IPR012602 PyrBI_leader # Organism LPPY_ECOLI Escherichia coli (strain K12) # PIR A24926 LPECBI # PIRSF PIRSF003249 PyrBI_leader # Pfam PF08052 PyrBI_leader # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LPPY_ECOLI PyrBI operon leader peptide # RefSeq NP_418667 NC_000913.3 # RefSeq WP_001296693 NZ_LN832404.1 # eggNOG ENOG4107C93 Bacteria # eggNOG ENOG410Z990 LUCA BLAST swissprot:LPPY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LPPY_ECOLI BioCyc ECOL316407:JW4205-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4205-MONOMER BioCyc EcoCyc:EG11279-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11279-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.80.2.368 http://dx.doi.org/10.1073/pnas.80.2.368 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M10743 http://www.ebi.ac.uk/ena/data/view/M10743 EMBL M60508 http://www.ebi.ac.uk/ena/data/view/M60508 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB1256 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1256 EcoGene EG11279 http://www.ecogene.org/geneInfo.php?eg_id=EG11279 EnsemblBacteria AAC77203 http://www.ensemblgenomes.org/id/AAC77203 EnsemblBacteria AAC77203 http://www.ensemblgenomes.org/id/AAC77203 EnsemblBacteria BAE78245 http://www.ensemblgenomes.org/id/BAE78245 EnsemblBacteria BAE78245 http://www.ensemblgenomes.org/id/BAE78245 EnsemblBacteria BAE78245 http://www.ensemblgenomes.org/id/BAE78245 EnsemblBacteria b4246 http://www.ensemblgenomes.org/id/b4246 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006221 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006221 GO_process GO:0019856 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019856 GO_process GO:0031555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031555 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 948768 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948768 HOGENOM HOG000009812 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009812&db=HOGENOM6 InterPro IPR012602 http://www.ebi.ac.uk/interpro/entry/IPR012602 KEGG_Gene ecj:JW4205 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4205 KEGG_Gene eco:b4246 http://www.genome.jp/dbget-bin/www_bget?eco:b4246 PSORT swissprot:LPPY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LPPY_ECOLI PSORT-B swissprot:LPPY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LPPY_ECOLI PSORT2 swissprot:LPPY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LPPY_ECOLI Pfam PF08052 http://pfam.xfam.org/family/PF08052 Phobius swissprot:LPPY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LPPY_ECOLI ProteinModelPortal P0AD83 http://www.proteinmodelportal.org/query/uniprot/P0AD83 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1699940 http://www.ncbi.nlm.nih.gov/pubmed/1699940 PubMed 3928602 http://www.ncbi.nlm.nih.gov/pubmed/3928602 PubMed 6300835 http://www.ncbi.nlm.nih.gov/pubmed/6300835 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418667 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418667 RefSeq WP_001296693 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001296693 STRING 511145.b4246 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4246&targetmode=cogs UniProtKB LPPY_ECOLI http://www.uniprot.org/uniprot/LPPY_ECOLI UniProtKB-AC P0AD83 http://www.uniprot.org/uniprot/P0AD83 charge swissprot:LPPY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LPPY_ECOLI eggNOG ENOG4107C93 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107C93 eggNOG ENOG410Z990 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Z990 epestfind swissprot:LPPY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LPPY_ECOLI garnier swissprot:LPPY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LPPY_ECOLI helixturnhelix swissprot:LPPY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LPPY_ECOLI hmoment swissprot:LPPY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LPPY_ECOLI iep swissprot:LPPY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LPPY_ECOLI inforesidue swissprot:LPPY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LPPY_ECOLI octanol swissprot:LPPY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LPPY_ECOLI pepcoil swissprot:LPPY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LPPY_ECOLI pepdigest swissprot:LPPY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LPPY_ECOLI pepinfo swissprot:LPPY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LPPY_ECOLI pepnet swissprot:LPPY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LPPY_ECOLI pepstats swissprot:LPPY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LPPY_ECOLI pepwheel swissprot:LPPY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LPPY_ECOLI pepwindow swissprot:LPPY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LPPY_ECOLI sigcleave swissprot:LPPY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LPPY_ECOLI ## Database ID URL or Descriptions # BioGrid 4262560 5 # EcoGene EG11964 yibL # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # IntAct P0ADK8 47 # InterPro IPR021230 DUF2810 # KEGG_Brite ko03009 Ribosome biogenesis # Organism YIBL_ECOLI Escherichia coli (strain K12) # PATRIC 32122689 VBIEscCol129921_3721 # PIR S47823 S47823 # Pfam PF10928 DUF2810 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIBL_ECOLI Uncharacterized protein YibL # RefSeq NP_418059 NC_000913.3 # RefSeq WP_000665680 NZ_LN832404.1 # SUBCELLULAR LOCATION YIBL_ECOLI Cytoplasm {ECO 0000269|PubMed 16980477}. Note=Has been seen to comigrate with the 50S ribosomal subunit in sucrose gradients. # eggNOG ENOG4108YYI Bacteria # eggNOG ENOG4111N40 LUCA BLAST swissprot:YIBL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIBL_ECOLI BioCyc ECOL316407:JW3577-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3577-MONOMER BioCyc EcoCyc:EG11964-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11964-MONOMER DIP DIP-35909N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35909N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1111/j.1365-2958.1990.tb02050.x http://dx.doi.org/10.1111/j.1365-2958.1990.tb02050.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00444-06 http://dx.doi.org/10.1128/JB.00444-06 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L13970 http://www.ebi.ac.uk/ena/data/view/L13970 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U03845 http://www.ebi.ac.uk/ena/data/view/U03845 EMBL X51359 http://www.ebi.ac.uk/ena/data/view/X51359 EchoBASE EB1907 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1907 EcoGene EG11964 http://www.ecogene.org/geneInfo.php?eg_id=EG11964 EnsemblBacteria AAC76626 http://www.ensemblgenomes.org/id/AAC76626 EnsemblBacteria AAC76626 http://www.ensemblgenomes.org/id/AAC76626 EnsemblBacteria BAE77690 http://www.ensemblgenomes.org/id/BAE77690 EnsemblBacteria BAE77690 http://www.ensemblgenomes.org/id/BAE77690 EnsemblBacteria BAE77690 http://www.ensemblgenomes.org/id/BAE77690 EnsemblBacteria b3602 http://www.ensemblgenomes.org/id/b3602 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GeneID 948115 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948115 HOGENOM HOG000293716 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000293716&db=HOGENOM6 IntAct P0ADK8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADK8* InterPro IPR021230 http://www.ebi.ac.uk/interpro/entry/IPR021230 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW3577 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3577 KEGG_Gene eco:b3602 http://www.genome.jp/dbget-bin/www_bget?eco:b3602 KEGG_Orthology KO:K14762 http://www.genome.jp/dbget-bin/www_bget?KO:K14762 MINT MINT-1237619 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1237619 OMA RIDTCRR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RIDTCRR PSORT swissprot:YIBL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIBL_ECOLI PSORT-B swissprot:YIBL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIBL_ECOLI PSORT2 swissprot:YIBL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIBL_ECOLI Pfam PF10928 http://pfam.xfam.org/family/PF10928 Phobius swissprot:YIBL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIBL_ECOLI ProteinModelPortal P0ADK8 http://www.proteinmodelportal.org/query/uniprot/P0ADK8 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16980477 http://www.ncbi.nlm.nih.gov/pubmed/16980477 PubMed 1964486 http://www.ncbi.nlm.nih.gov/pubmed/1964486 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 8300537 http://www.ncbi.nlm.nih.gov/pubmed/8300537 PubMed 8407843 http://www.ncbi.nlm.nih.gov/pubmed/8407843 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418059 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418059 RefSeq WP_000665680 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000665680 SMR P0ADK8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADK8 STRING 511145.b3602 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3602&targetmode=cogs UniProtKB YIBL_ECOLI http://www.uniprot.org/uniprot/YIBL_ECOLI UniProtKB-AC P0ADK8 http://www.uniprot.org/uniprot/P0ADK8 charge swissprot:YIBL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIBL_ECOLI eggNOG ENOG4108YYI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108YYI eggNOG ENOG4111N40 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111N40 epestfind swissprot:YIBL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIBL_ECOLI garnier swissprot:YIBL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIBL_ECOLI helixturnhelix swissprot:YIBL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIBL_ECOLI hmoment swissprot:YIBL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIBL_ECOLI iep swissprot:YIBL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIBL_ECOLI inforesidue swissprot:YIBL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIBL_ECOLI octanol swissprot:YIBL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIBL_ECOLI pepcoil swissprot:YIBL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIBL_ECOLI pepdigest swissprot:YIBL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIBL_ECOLI pepinfo swissprot:YIBL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIBL_ECOLI pepnet swissprot:YIBL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIBL_ECOLI pepstats swissprot:YIBL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIBL_ECOLI pepwheel swissprot:YIBL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIBL_ECOLI pepwindow swissprot:YIBL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIBL_ECOLI sigcleave swissprot:YIBL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIBL_ECOLI ## Database ID URL or Descriptions # BioGrid 4261746 13 # EcoGene EG11164 ygiB # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_process GO:0044010 single-species biofilm formation; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0008150 biological_process # HAMAP MF_01188 UPF0441 # InterPro IPR009576 Biofilm_formation_YgiB # Organism YGIB_ECOLI Escherichia coli (strain K12) # PATRIC 32121484 VBIEscCol129921_3129 # PIR S22360 S22360 # Pfam PF06693 DUF1190 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGIB_ECOLI UPF0441 protein YgiB # RefSeq NP_417509 NC_000913.3 # RefSeq WP_000831543 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA69205.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAA71875.1; Type=Erroneous initiation; Evidence={ECO 0000305}; Sequence=BAE77093.1; Type=Erroneous initiation; Evidence={ECO:0000305}; # SIMILARITY Belongs to the UPF0441 family. {ECO 0000305}. # eggNOG COG5463 LUCA # eggNOG ENOG4105F1G Bacteria BLAST swissprot:YGIB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGIB_ECOLI BioCyc ECOL316407:JW5927-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5927-MONOMER BioCyc EcoCyc:EG11164-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11164-MONOMER DOI 10.1016/0167-4781(92)90535-8 http://dx.doi.org/10.1016/0167-4781(92)90535-8 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M77129 http://www.ebi.ac.uk/ena/data/view/M77129 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB1152 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1152 EcoGene EG11164 http://www.ecogene.org/geneInfo.php?eg_id=EG11164 EnsemblBacteria AAC76073 http://www.ensemblgenomes.org/id/AAC76073 EnsemblBacteria AAC76073 http://www.ensemblgenomes.org/id/AAC76073 EnsemblBacteria BAE77093 http://www.ensemblgenomes.org/id/BAE77093 EnsemblBacteria BAE77093 http://www.ensemblgenomes.org/id/BAE77093 EnsemblBacteria BAE77093 http://www.ensemblgenomes.org/id/BAE77093 EnsemblBacteria b3037 http://www.ensemblgenomes.org/id/b3037 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_process GO:0044010 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044010 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 945086 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945086 HAMAP MF_01188 http://hamap.expasy.org/unirule/MF_01188 HOGENOM HOG000140314 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000140314&db=HOGENOM6 InterPro IPR009576 http://www.ebi.ac.uk/interpro/entry/IPR009576 KEGG_Gene ecj:JW5927 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5927 KEGG_Gene eco:b3037 http://www.genome.jp/dbget-bin/www_bget?eco:b3037 OMA CEQSDET http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CEQSDET PSORT swissprot:YGIB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGIB_ECOLI PSORT-B swissprot:YGIB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGIB_ECOLI PSORT2 swissprot:YGIB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGIB_ECOLI Pfam PF06693 http://pfam.xfam.org/family/PF06693 Phobius swissprot:YGIB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGIB_ECOLI ProteinModelPortal P0ADT2 http://www.proteinmodelportal.org/query/uniprot/P0ADT2 PubMed 1314093 http://www.ncbi.nlm.nih.gov/pubmed/1314093 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417509 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417509 RefSeq WP_000831543 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000831543 STRING 511145.b3037 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3037&targetmode=cogs UniProtKB YGIB_ECOLI http://www.uniprot.org/uniprot/YGIB_ECOLI UniProtKB-AC P0ADT2 http://www.uniprot.org/uniprot/P0ADT2 charge swissprot:YGIB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGIB_ECOLI eggNOG COG5463 http://eggnogapi.embl.de/nog_data/html/tree/COG5463 eggNOG ENOG4105F1G http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F1G epestfind swissprot:YGIB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGIB_ECOLI garnier swissprot:YGIB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGIB_ECOLI helixturnhelix swissprot:YGIB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGIB_ECOLI hmoment swissprot:YGIB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGIB_ECOLI iep swissprot:YGIB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGIB_ECOLI inforesidue swissprot:YGIB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGIB_ECOLI octanol swissprot:YGIB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGIB_ECOLI pepcoil swissprot:YGIB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGIB_ECOLI pepdigest swissprot:YGIB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGIB_ECOLI pepinfo swissprot:YGIB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGIB_ECOLI pepnet swissprot:YGIB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGIB_ECOLI pepstats swissprot:YGIB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGIB_ECOLI pepwheel swissprot:YGIB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGIB_ECOLI pepwindow swissprot:YGIB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGIB_ECOLI sigcleave swissprot:YGIB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGIB_ECOLI ## Database ID URL or Descriptions # AltName N5-glutamine methyltransferase PrmC {ECO:0000255|HAMAP-Rule MF_02126} # AltName PRMC_ECOLI M.EcoKHemKP # AltName PRMC_ECOLI Protein release factor methylation C # AltName Protein-(glutamine-N5) MTase PrmC {ECO:0000255|HAMAP-Rule MF_02126} # AltName Protein-glutamine N-methyltransferase PrmC {ECO:0000255|HAMAP-Rule MF_02126} # BRENDA 2.1.1.297 2026 # CATALYTIC ACTIVITY PRMC_ECOLI S-adenosyl-L-methionine + [peptide chain release factor 1 or 2]-L-glutamine = S-adenosyl-L-homocysteine + [peptide chain release factor 1 or 2]-N(5)-methyl-L-glutamine. {ECO 0000269|PubMed 11805295, ECO 0000269|PubMed 11847124}. # CAUTION Was originally thought to be involved in the oxidation of protoporphyrinogen into protoporphyrin IX. {ECO:0000305|PubMed 7883187}. # DISRUPTION PHENOTYPE Cells lacking this gene suffer severe growth defects, but also show a global shift in gene expression to anaerobic respiration. Also show defects in translational termination via an enhanced rate of read-through of nonsense codons and induction of transfer-mRNA-mediated tagging of proteins within the cell. {ECO:0000269|PubMed 11805295}. # EcoGene EG12424 prmC # FUNCTION PRMC_ECOLI Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif, i.e. on 'Gln-235' in RF1 and on 'Gln-252' in RF2. {ECO 0000269|PubMed 11805295, ECO 0000269|PubMed 11847124, ECO 0000269|PubMed 16364916}. # GO_function GO:0003676 nucleic acid binding; IEA:InterPro. # GO_function GO:0008276 protein methyltransferase activity; IDA:UniProtKB. # GO_function GO:0008757 S-adenosylmethionine-dependent methyltransferase activity; IDA:UniProtKB. # GO_function GO:0036009 protein-glutamine N-methyltransferase activity; IDA:UniProtKB. # GO_process GO:0006415 translational termination; IMP:UniProtKB. # GO_process GO:0006479 protein methylation; IDA:UniProtKB. # GO_process GO:0010468 regulation of gene expression; IMP:UniProtKB. # GO_process GO:0018364 peptidyl-glutamine methylation; IDA:UniProtKB. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.150 -; 1. # HAMAP MF_02126 RF_methyltr_PrmC # InterPro IPR002052 DNA_methylase_N6_adenine_CS # InterPro IPR004556 Modification_methylase_HemK # InterPro IPR019874 Release_fac_Glu-N5_MeTfrase # InterPro IPR025714 Methyltranfer_dom # InterPro IPR029063 SAM-dependent_MTases # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03012 Translation factors # Organism PRMC_ECOLI Escherichia coli (strain K12) # PATRIC 32117676 VBIEscCol129921_1260 # PDB 1T43 X-ray; 3.20 A; A=1-277 # PDB 2B3T X-ray; 3.10 A; A=1-276 # PIR I83570 I83570 # Pfam PF13847 Methyltransf_31 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Release factor glutamine methyltransferase {ECO:0000255|HAMAP-Rule MF_02126} # RefSeq NP_415730 NC_000913.3 # RefSeq WP_000456467 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA05915.1; Type=Frameshift; Positions=204; Evidence={ECO 0000305}; # SIMILARITY Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. {ECO:0000255|HAMAP-Rule MF_02126}. # SUBUNIT PRMC_ECOLI Interacts with PrfA and PrfB. {ECO 0000269|PubMed 15223314, ECO 0000269|PubMed 16364916}. # SUPFAM SSF53335 SSF53335 # TIGRFAMs TIGR00536 hemK_fam # TIGRFAMs TIGR03534 RF_mod_PrmC # eggNOG COG2890 LUCA # eggNOG ENOG4105EQY Bacteria BLAST swissprot:PRMC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PRMC_ECOLI BioCyc ECOL316407:JW1203-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1203-MONOMER BioCyc EcoCyc:EG12424-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12424-MONOMER BioCyc MetaCyc:EG12424-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12424-MONOMER COG COG2890 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2890 DOI 10.1016/0378-1119(94)00805-3 http://dx.doi.org/10.1016/0378-1119(94)00805-3 DOI 10.1016/j.jmb.2004.05.019 http://dx.doi.org/10.1016/j.jmb.2004.05.019 DOI 10.1016/j.molcel.2005.10.025 http://dx.doi.org/10.1016/j.molcel.2005.10.025 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.032488499 http://dx.doi.org/10.1073/pnas.032488499 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/emboj/21.4.769 http://dx.doi.org/10.1093/emboj/21.4.769 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.1.297 {ECO:0000269|PubMed:11805295, ECO:0000269|PubMed:11847124} http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.297 {ECO:0000269|PubMed:11805295, ECO:0000269|PubMed:11847124} EMBL AB078778 http://www.ebi.ac.uk/ena/data/view/AB078778 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D28567 http://www.ebi.ac.uk/ena/data/view/D28567 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18555 http://www.ebi.ac.uk/ena/data/view/U18555 ENZYME 2.1.1.297 {ECO:0000269|PubMed:11805295, ECO:0000269|PubMed:11847124} http://enzyme.expasy.org/EC/2.1.1.297 {ECO:0000269|PubMed:11805295, ECO:0000269|PubMed:11847124} EchoBASE EB2323 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2323 EcoGene EG12424 http://www.ecogene.org/geneInfo.php?eg_id=EG12424 EnsemblBacteria AAC74296 http://www.ensemblgenomes.org/id/AAC74296 EnsemblBacteria AAC74296 http://www.ensemblgenomes.org/id/AAC74296 EnsemblBacteria BAA36070 http://www.ensemblgenomes.org/id/BAA36070 EnsemblBacteria BAA36070 http://www.ensemblgenomes.org/id/BAA36070 EnsemblBacteria BAA36070 http://www.ensemblgenomes.org/id/BAA36070 EnsemblBacteria b1212 http://www.ensemblgenomes.org/id/b1212 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003676 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003676 GO_function GO:0008276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008276 GO_function GO:0008757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008757 GO_function GO:0036009 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036009 GO_process GO:0006415 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006415 GO_process GO:0006479 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006479 GO_process GO:0010468 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010468 GO_process GO:0018364 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018364 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 GeneID 945779 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945779 HAMAP MF_02126 http://hamap.expasy.org/unirule/MF_02126 HOGENOM HOG000076274 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000076274&db=HOGENOM6 InParanoid P0ACC1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACC1 IntAct P0ACC1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACC1* IntEnz 2.1.1.297 {ECO:0000269|PubMed:11805295, ECO:0000269|PubMed:11847124} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.297 {ECO:0000269|PubMed:11805295, ECO:0000269|PubMed:11847124} InterPro IPR002052 http://www.ebi.ac.uk/interpro/entry/IPR002052 InterPro IPR004556 http://www.ebi.ac.uk/interpro/entry/IPR004556 InterPro IPR019874 http://www.ebi.ac.uk/interpro/entry/IPR019874 InterPro IPR025714 http://www.ebi.ac.uk/interpro/entry/IPR025714 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03012 http://www.genome.jp/dbget-bin/www_bget?ko03012 KEGG_Gene ecj:JW1203 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1203 KEGG_Gene eco:b1212 http://www.genome.jp/dbget-bin/www_bget?eco:b1212 KEGG_Orthology KO:K02493 http://www.genome.jp/dbget-bin/www_bget?KO:K02493 OMA HGWTQGE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HGWTQGE PDB 1T43 http://www.ebi.ac.uk/pdbe-srv/view/entry/1T43 PDB 2B3T http://www.ebi.ac.uk/pdbe-srv/view/entry/2B3T PDBsum 1T43 http://www.ebi.ac.uk/pdbsum/1T43 PDBsum 2B3T http://www.ebi.ac.uk/pdbsum/2B3T PSORT swissprot:PRMC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PRMC_ECOLI PSORT-B swissprot:PRMC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PRMC_ECOLI PSORT2 swissprot:PRMC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PRMC_ECOLI Pfam PF13847 http://pfam.xfam.org/family/PF13847 Phobius swissprot:PRMC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PRMC_ECOLI PhylomeDB P0ACC1 http://phylomedb.org/?seqid=P0ACC1 ProteinModelPortal P0ACC1 http://www.proteinmodelportal.org/query/uniprot/P0ACC1 PubMed 11805295 http://www.ncbi.nlm.nih.gov/pubmed/11805295 PubMed 11847124 http://www.ncbi.nlm.nih.gov/pubmed/11847124 PubMed 15223314 http://www.ncbi.nlm.nih.gov/pubmed/15223314 PubMed 16364916 http://www.ncbi.nlm.nih.gov/pubmed/16364916 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7543480 http://www.ncbi.nlm.nih.gov/pubmed/7543480 PubMed 7883187 http://www.ncbi.nlm.nih.gov/pubmed/7883187 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415730 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415730 RefSeq WP_000456467 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000456467 SMR P0ACC1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACC1 STRING 511145.b1212 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1212&targetmode=cogs STRING COG2890 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2890&targetmode=cogs SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 TIGRFAMs TIGR00536 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00536 TIGRFAMs TIGR03534 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03534 UniProtKB PRMC_ECOLI http://www.uniprot.org/uniprot/PRMC_ECOLI UniProtKB-AC P0ACC1 http://www.uniprot.org/uniprot/P0ACC1 charge swissprot:PRMC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PRMC_ECOLI eggNOG COG2890 http://eggnogapi.embl.de/nog_data/html/tree/COG2890 eggNOG ENOG4105EQY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EQY epestfind swissprot:PRMC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PRMC_ECOLI garnier swissprot:PRMC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PRMC_ECOLI helixturnhelix swissprot:PRMC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PRMC_ECOLI hmoment swissprot:PRMC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PRMC_ECOLI iep swissprot:PRMC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PRMC_ECOLI inforesidue swissprot:PRMC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PRMC_ECOLI octanol swissprot:PRMC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PRMC_ECOLI pepcoil swissprot:PRMC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PRMC_ECOLI pepdigest swissprot:PRMC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PRMC_ECOLI pepinfo swissprot:PRMC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PRMC_ECOLI pepnet swissprot:PRMC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PRMC_ECOLI pepstats swissprot:PRMC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PRMC_ECOLI pepwheel swissprot:PRMC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PRMC_ECOLI pepwindow swissprot:PRMC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PRMC_ECOLI sigcleave swissprot:PRMC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PRMC_ECOLI ## Database ID URL or Descriptions # BioGrid 4262097 13 # CDD cd00207 fer2 # COFACTOR Name=FAD; Xref=ChEBI:CHEBI 57692; # COFACTOR Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI 49601; Note=Binds 1 [2Fe-2S] cluster.; # EcoGene EG13691 hcr # FUNCTION HCR_ECOLI NADH oxidoreductase acting in concert with HCP. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0009055 electron carrier activity; IEA:InterPro. # GO_function GO:0016651 oxidoreductase activity, acting on NAD(P)H; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0050660 flavin adenine dinucleotide binding; IDA:EcoCyc. # GO_function GO:0051537 2 iron, 2 sulfur cluster binding; IDA:EcoCyc. # GO_function GO:0071949 FAD binding; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # Gene3D 3.10.20.30 -; 1. # IntAct P75824 16 # InterPro IPR000951 Ph_dOase_redase # InterPro IPR001041 2Fe-2S_ferredoxin-type # InterPro IPR001433 OxRdtase_FAD/NAD-bd # InterPro IPR008333 OxRdtase_FAD-bd_dom # InterPro IPR012675 Beta-grasp_dom # InterPro IPR017927 Fd_Rdtase_FAD-bd # InterPro IPR017938 Riboflavin_synthase-like_b-brl # KEGG_Brite ko01000 Enzymes # Organism HCR_ECOLI Escherichia coli (strain K12) # PATRIC 32116951 VBIEscCol129921_0901 # PIR H64825 H64825 # PRINTS PR00409 PHDIOXRDTASE # PROSITE PS51085 2FE2S_FER_2 # PROSITE PS51384 FAD_FR # Pfam PF00111 Fer2 # Pfam PF00175 NAD_binding_1 # Pfam PF00970 FAD_binding_6 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HCR_ECOLI NADH oxidoreductase HCR # RefSeq NP_415393 NC_000913.3 # RefSeq WP_000178677 NZ_LN832404.1 # SIMILARITY Contains 1 2Fe-2S ferredoxin-type domain. {ECO:0000255|PROSITE-ProRule PRU00465}. # SIMILARITY Contains 1 FAD-binding FR-type domain. {ECO:0000255|PROSITE-ProRule PRU00716}. # SIMILARITY In the N-terminal section; belongs to the FAD-binding oxidoreductase type 6 family. {ECO 0000305}. # SUPFAM SSF54292 SSF54292 # SUPFAM SSF63380 SSF63380 # eggNOG COG1018 LUCA # eggNOG ENOG4105CJJ Bacteria BLAST swissprot:HCR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HCR_ECOLI BioCyc ECOL316407:JW5117-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5117-MONOMER BioCyc EcoCyc:G6456-MONOMER http://biocyc.org/getid?id=EcoCyc:G6456-MONOMER BioCyc MetaCyc:G6456-MONOMER http://biocyc.org/getid?id=MetaCyc:G6456-MONOMER COG COG1018 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1018 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1432-1327.2000.01032.x http://dx.doi.org/10.1046/j.1432-1327.2000.01032.x DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- EchoBASE EB3455 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3455 EcoGene EG13691 http://www.ecogene.org/geneInfo.php?eg_id=EG13691 EnsemblBacteria AAC73959 http://www.ensemblgenomes.org/id/AAC73959 EnsemblBacteria AAC73959 http://www.ensemblgenomes.org/id/AAC73959 EnsemblBacteria BAA35586 http://www.ensemblgenomes.org/id/BAA35586 EnsemblBacteria BAA35586 http://www.ensemblgenomes.org/id/BAA35586 EnsemblBacteria BAA35586 http://www.ensemblgenomes.org/id/BAA35586 EnsemblBacteria b0872 http://www.ensemblgenomes.org/id/b0872 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0016651 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016651 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_function GO:0051537 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051537 GO_function GO:0071949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071949 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.10.20.30 http://www.cathdb.info/version/latest/superfamily/3.10.20.30 GeneID 947660 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947660 HOGENOM HOG000141050 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000141050&db=HOGENOM6 InParanoid P75824 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75824 IntAct P75824 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75824* IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR000951 http://www.ebi.ac.uk/interpro/entry/IPR000951 InterPro IPR001041 http://www.ebi.ac.uk/interpro/entry/IPR001041 InterPro IPR001433 http://www.ebi.ac.uk/interpro/entry/IPR001433 InterPro IPR008333 http://www.ebi.ac.uk/interpro/entry/IPR008333 InterPro IPR012675 http://www.ebi.ac.uk/interpro/entry/IPR012675 InterPro IPR017927 http://www.ebi.ac.uk/interpro/entry/IPR017927 InterPro IPR017938 http://www.ebi.ac.uk/interpro/entry/IPR017938 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5117 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5117 KEGG_Gene eco:b0872 http://www.genome.jp/dbget-bin/www_bget?eco:b0872 KEGG_Orthology KO:K11933 http://www.genome.jp/dbget-bin/www_bget?KO:K11933 OMA LMIPKAC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LMIPKAC PRINTS PR00409 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00409 PROSITE PS51085 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51085 PROSITE PS51384 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51384 PSORT swissprot:HCR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HCR_ECOLI PSORT-B swissprot:HCR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HCR_ECOLI PSORT2 swissprot:HCR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HCR_ECOLI Pfam PF00111 http://pfam.xfam.org/family/PF00111 Pfam PF00175 http://pfam.xfam.org/family/PF00175 Pfam PF00970 http://pfam.xfam.org/family/PF00970 Phobius swissprot:HCR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HCR_ECOLI PhylomeDB P75824 http://phylomedb.org/?seqid=P75824 ProteinModelPortal P75824 http://www.proteinmodelportal.org/query/uniprot/P75824 PubMed 10651802 http://www.ncbi.nlm.nih.gov/pubmed/10651802 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415393 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415393 RefSeq WP_000178677 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000178677 SMR P75824 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75824 STRING 511145.b0872 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0872&targetmode=cogs STRING COG1018 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1018&targetmode=cogs SUPFAM SSF54292 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54292 SUPFAM SSF63380 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63380 UniProtKB HCR_ECOLI http://www.uniprot.org/uniprot/HCR_ECOLI UniProtKB-AC P75824 http://www.uniprot.org/uniprot/P75824 charge swissprot:HCR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HCR_ECOLI eggNOG COG1018 http://eggnogapi.embl.de/nog_data/html/tree/COG1018 eggNOG ENOG4105CJJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CJJ epestfind swissprot:HCR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HCR_ECOLI garnier swissprot:HCR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HCR_ECOLI helixturnhelix swissprot:HCR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HCR_ECOLI hmoment swissprot:HCR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HCR_ECOLI iep swissprot:HCR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HCR_ECOLI inforesidue swissprot:HCR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HCR_ECOLI octanol swissprot:HCR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HCR_ECOLI pepcoil swissprot:HCR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HCR_ECOLI pepdigest swissprot:HCR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HCR_ECOLI pepinfo swissprot:HCR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HCR_ECOLI pepnet swissprot:HCR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HCR_ECOLI pepstats swissprot:HCR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HCR_ECOLI pepwheel swissprot:HCR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HCR_ECOLI pepwindow swissprot:HCR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HCR_ECOLI sigcleave swissprot:HCR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HCR_ECOLI ## Database ID URL or Descriptions # EcoGene EG40003 insC5 # FUNCTION INSC5_ECOLI Involved in the transposition of the insertion sequence IS2. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 1.10.10.60 -; 1. # InterPro IPR002514 Transposase_8 # InterPro IPR009057 Homeodomain-like # Organism INSC5_ECOLI Escherichia coli (strain K12) # PIR B65240 B65240 # Pfam PF01527 HTH_Tnp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSC5_ECOLI Transposase InsC for insertion element IS2I # RefSeq NP_414894 NC_000913.3 # RefSeq NP_415921 NC_000913.3 # RefSeq NP_417338 NC_000913.3 # RefSeq NP_417516 NC_000913.3 # RefSeq NP_418692 NC_000913.3 # RefSeq WP_000567766 NZ_LN832404.1 # RefSeq YP_026163 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA69212.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAE77100.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the transposase 8 family. {ECO 0000305}. # SUPFAM SSF46689 SSF46689 # eggNOG COG2963 LUCA # eggNOG ENOG4108ZQS Bacteria BLAST swissprot:INSC5_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSC5_ECOLI BioCyc EcoCyc:MONOMER0-4253 http://biocyc.org/getid?id=EcoCyc:MONOMER0-4253 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB4740 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4740 EcoGene EG40003 http://www.ecogene.org/geneInfo.php?eg_id=EG40003 EnsemblBacteria AAC76080 http://www.ensemblgenomes.org/id/AAC76080 EnsemblBacteria AAC76080 http://www.ensemblgenomes.org/id/AAC76080 EnsemblBacteria BAE77100 http://www.ensemblgenomes.org/id/BAE77100 EnsemblBacteria BAE77100 http://www.ensemblgenomes.org/id/BAE77100 EnsemblBacteria BAE77100 http://www.ensemblgenomes.org/id/BAE77100 EnsemblBacteria b3044 http://www.ensemblgenomes.org/id/b3044 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 GeneID 945025 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945025 GeneID 945967 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945967 GeneID 946455 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946455 GeneID 947347 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947347 GeneID 947520 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947520 GeneID 948781 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948781 InParanoid P0CF44 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CF44 InterPro IPR002514 http://www.ebi.ac.uk/interpro/entry/IPR002514 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 KEGG_Gene ecj:JW3012 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3012 KEGG_Gene eco:b0360 http://www.genome.jp/dbget-bin/www_bget?eco:b0360 KEGG_Gene eco:b1403 http://www.genome.jp/dbget-bin/www_bget?eco:b1403 KEGG_Gene eco:b1997 http://www.genome.jp/dbget-bin/www_bget?eco:b1997 KEGG_Gene eco:b2861 http://www.genome.jp/dbget-bin/www_bget?eco:b2861 KEGG_Gene eco:b3044 http://www.genome.jp/dbget-bin/www_bget?eco:b3044 KEGG_Gene eco:b4272 http://www.genome.jp/dbget-bin/www_bget?eco:b4272 PSORT swissprot:INSC5_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSC5_ECOLI PSORT-B swissprot:INSC5_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSC5_ECOLI PSORT2 swissprot:INSC5_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSC5_ECOLI Pfam PF01527 http://pfam.xfam.org/family/PF01527 Phobius swissprot:INSC5_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSC5_ECOLI PhylomeDB P0CF44 http://phylomedb.org/?seqid=P0CF44 ProteinModelPortal P0CF44 http://www.proteinmodelportal.org/query/uniprot/P0CF44 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414894 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414894 RefSeq NP_415921 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415921 RefSeq NP_417338 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417338 RefSeq NP_417516 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417516 RefSeq NP_418692 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418692 RefSeq WP_000567766 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000567766 RefSeq YP_026163 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026163 STRING 511145.b4272 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4272&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 UniProtKB INSC5_ECOLI http://www.uniprot.org/uniprot/INSC5_ECOLI UniProtKB-AC P0CF44 http://www.uniprot.org/uniprot/P0CF44 charge swissprot:INSC5_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSC5_ECOLI eggNOG COG2963 http://eggnogapi.embl.de/nog_data/html/tree/COG2963 eggNOG ENOG4108ZQS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZQS epestfind swissprot:INSC5_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSC5_ECOLI garnier swissprot:INSC5_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSC5_ECOLI helixturnhelix swissprot:INSC5_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSC5_ECOLI hmoment swissprot:INSC5_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSC5_ECOLI iep swissprot:INSC5_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSC5_ECOLI inforesidue swissprot:INSC5_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSC5_ECOLI octanol swissprot:INSC5_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSC5_ECOLI pepcoil swissprot:INSC5_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSC5_ECOLI pepdigest swissprot:INSC5_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSC5_ECOLI pepinfo swissprot:INSC5_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSC5_ECOLI pepnet swissprot:INSC5_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSC5_ECOLI pepstats swissprot:INSC5_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSC5_ECOLI pepwheel swissprot:INSC5_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSC5_ECOLI pepwindow swissprot:INSC5_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSC5_ECOLI sigcleave swissprot:INSC5_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSC5_ECOLI ## Database ID URL or Descriptions # AltName AMPA_ECOLI Aminopeptidase A/I # AltName AMPA_ECOLI Leucine aminopeptidase # AltName AMPA_ECOLI Leucyl aminopeptidase # BioGrid 4262726 7 # CATALYTIC ACTIVITY AMPA_ECOLI Release of an N-terminal amino acid, Xaa-|- Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low. # CATALYTIC ACTIVITY AMPA_ECOLI Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids. # CAUTION The ligation for manganese is based on the ligation for zinc, an inhibitor, in the crystallographic structure reported in PubMed:10449417. The ligation for manganese in the active form of the enzyme may differ. {ECO 0000305}. # CDD cd00433 Peptidase_M17 # COFACTOR AMPA_ECOLI Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000250}; Note=Binds 2 manganese ions per subunit. {ECO 0000250}; # DISRUPTION PHENOTYPE A quadruple peptidase disruption (pepA, pepB, pepD and pepN) does not grow in M9 minimal medium, grows better when supplemented with casamino acids (PubMed:20067529). {ECO 0000269|PubMed:20067529}. # ENZYME REGULATION AMPA_ECOLI Inhibited by zinc and EDTA. # EcoGene EG10694 pepA # FUNCTION AMPA_ECOLI Probably involved in the processing and regular turnover of intracellular proteins (PubMed 20067529). Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides. Required for plasmid ColE1 site-specific recombination but not in its aminopeptidase activity. Could act as a structural component of the putative nucleoprotein complex in which the Xer recombination reaction takes place (PubMed 8057849). {ECO 0000269|PubMed 8057849, ECO 0000305|PubMed 20067529}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-HAMAP. # GO_function GO:0001073 transcription antitermination factor activity, DNA binding; IMP:EcoliWiki. # GO_function GO:0003677 DNA binding; IDA:EcoliWiki. # GO_function GO:0004177 aminopeptidase activity; IDA:EcoliWiki. # GO_function GO:0008235 metalloexopeptidase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0030145 manganese ion binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006276 plasmid maintenance; IMP:EcoliWiki. # GO_process GO:0006351 transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0042150 plasmid recombination; IMP:EcoliWiki. # GO_process GO:0043171 peptide catabolic process; IMP:EcoliWiki. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # HAMAP MF_00181 Cytosol_peptidase_M17 # IntAct P68767 5 # InterPro IPR000819 Peptidase_M17_C # InterPro IPR008283 Peptidase_M17_N # InterPro IPR011356 Leucine_aapep/pepB # InterPro IPR023042 Peptidase_M17_leu_NH2_pept # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # KEGG_Pathway ko00480 Glutathione metabolism # Organism AMPA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11963 PTHR11963 # PATRIC 32124091 VBIEscCol129921_4390 # PDB 1GYT X-ray; 2.50 A; A/B/C/D/E/F/G/H/I/J/K/L=1-503 # PIR S04462 APECA # PRINTS PR00481 LAMNOPPTDASE # PROSITE PS00631 CYTOSOL_AP # Pfam PF00883 Peptidase_M17 # Pfam PF02789 Peptidase_M17_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AMPA_ECOLI Cytosol aminopeptidase # RefSeq NP_418681 NC_000913.3 # RefSeq WP_000397144 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase M17 family. {ECO 0000305}. # SUBUNIT AMPA_ECOLI Homohexamer. # eggNOG COG0260 LUCA # eggNOG ENOG4105BZ6 Bacteria BLAST swissprot:AMPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AMPA_ECOLI BioCyc ECOL316407:JW4217-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4217-MONOMER BioCyc EcoCyc:EG10694-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10694-MONOMER BioCyc MetaCyc:EG10694-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10694-MONOMER COG COG0260 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0260 DIP DIP-47860N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47860N DOI 10.1006/jmbi.1995.0385 http://dx.doi.org/10.1006/jmbi.1995.0385 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/emboj/18.16.4513 http://dx.doi.org/10.1093/emboj/18.16.4513 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1111/j.1365-2958.1994.tb01013.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb01013.x DOI 10.1111/j.1574-6968.2009.01879.x http://dx.doi.org/10.1111/j.1574-6968.2009.01879.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.11.1 http://www.genome.jp/dbget-bin/www_bget?EC:3.4.11.1 EC_number EC:3.4.11.10 http://www.genome.jp/dbget-bin/www_bget?EC:3.4.11.10 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X15130 http://www.ebi.ac.uk/ena/data/view/X15130 EMBL X86443 http://www.ebi.ac.uk/ena/data/view/X86443 ENZYME 3.4.11.1 http://enzyme.expasy.org/EC/3.4.11.1 ENZYME 3.4.11.10 http://enzyme.expasy.org/EC/3.4.11.10 EchoBASE EB0688 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0688 EcoGene EG10694 http://www.ecogene.org/geneInfo.php?eg_id=EG10694 EnsemblBacteria AAC77217 http://www.ensemblgenomes.org/id/AAC77217 EnsemblBacteria AAC77217 http://www.ensemblgenomes.org/id/AAC77217 EnsemblBacteria BAE78257 http://www.ensemblgenomes.org/id/BAE78257 EnsemblBacteria BAE78257 http://www.ensemblgenomes.org/id/BAE78257 EnsemblBacteria BAE78257 http://www.ensemblgenomes.org/id/BAE78257 EnsemblBacteria b4260 http://www.ensemblgenomes.org/id/b4260 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0001073 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001073 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004177 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004177 GO_function GO:0008235 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008235 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_process GO:0006276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006276 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0042150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042150 GO_process GO:0043171 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043171 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 948791 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948791 HAMAP MF_00181 http://hamap.expasy.org/unirule/MF_00181 HOGENOM HOG000243132 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000243132&db=HOGENOM6 InParanoid P68767 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P68767 IntAct P68767 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P68767* IntEnz 3.4.11.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.11.1 IntEnz 3.4.11.10 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.11.10 InterPro IPR000819 http://www.ebi.ac.uk/interpro/entry/IPR000819 InterPro IPR008283 http://www.ebi.ac.uk/interpro/entry/IPR008283 InterPro IPR011356 http://www.ebi.ac.uk/interpro/entry/IPR011356 InterPro IPR023042 http://www.ebi.ac.uk/interpro/entry/IPR023042 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW4217 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4217 KEGG_Gene eco:b4260 http://www.genome.jp/dbget-bin/www_bget?eco:b4260 KEGG_Orthology KO:K01255 http://www.genome.jp/dbget-bin/www_bget?KO:K01255 KEGG_Pathway ko00480 http://www.genome.jp/kegg-bin/show_pathway?ko00480 KEGG_Reaction rn:R00899 http://www.genome.jp/dbget-bin/www_bget?rn:R00899 KEGG_Reaction rn:R04951 http://www.genome.jp/dbget-bin/www_bget?rn:R04951 OMA AICEMKL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AICEMKL PANTHER PTHR11963 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11963 PDB 1GYT http://www.ebi.ac.uk/pdbe-srv/view/entry/1GYT PDBsum 1GYT http://www.ebi.ac.uk/pdbsum/1GYT PRINTS PR00481 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00481 PROSITE PS00631 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00631 PSORT swissprot:AMPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AMPA_ECOLI PSORT-B swissprot:AMPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AMPA_ECOLI PSORT2 swissprot:AMPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AMPA_ECOLI Pfam PF00883 http://pfam.xfam.org/family/PF00883 Pfam PF02789 http://pfam.xfam.org/family/PF02789 Phobius swissprot:AMPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AMPA_ECOLI PhylomeDB P68767 http://phylomedb.org/?seqid=P68767 ProteinModelPortal P68767 http://www.proteinmodelportal.org/query/uniprot/P68767 PubMed 10449417 http://www.ncbi.nlm.nih.gov/pubmed/10449417 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20067529 http://www.ncbi.nlm.nih.gov/pubmed/20067529 PubMed 2670557 http://www.ncbi.nlm.nih.gov/pubmed/2670557 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 7616564 http://www.ncbi.nlm.nih.gov/pubmed/7616564 PubMed 8057849 http://www.ncbi.nlm.nih.gov/pubmed/8057849 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418681 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418681 RefSeq WP_000397144 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000397144 SMR P68767 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P68767 STRING 511145.b4260 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4260&targetmode=cogs STRING COG0260 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0260&targetmode=cogs UniProtKB AMPA_ECOLI http://www.uniprot.org/uniprot/AMPA_ECOLI UniProtKB-AC P68767 http://www.uniprot.org/uniprot/P68767 charge swissprot:AMPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AMPA_ECOLI eggNOG COG0260 http://eggnogapi.embl.de/nog_data/html/tree/COG0260 eggNOG ENOG4105BZ6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZ6 epestfind swissprot:AMPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AMPA_ECOLI garnier swissprot:AMPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AMPA_ECOLI helixturnhelix swissprot:AMPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AMPA_ECOLI hmoment swissprot:AMPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AMPA_ECOLI iep swissprot:AMPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AMPA_ECOLI inforesidue swissprot:AMPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AMPA_ECOLI octanol swissprot:AMPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AMPA_ECOLI pepcoil swissprot:AMPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AMPA_ECOLI pepdigest swissprot:AMPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AMPA_ECOLI pepinfo swissprot:AMPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AMPA_ECOLI pepnet swissprot:AMPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AMPA_ECOLI pepstats swissprot:AMPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AMPA_ECOLI pepwheel swissprot:AMPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AMPA_ECOLI pepwindow swissprot:AMPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AMPA_ECOLI sigcleave swissprot:AMPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AMPA_ECOLI ## Database ID URL or Descriptions # AltName DPPA_ECOLI Dipeptide-binding protein # BioGrid 4259528 143 # EcoGene EG10248 dppA # FUNCTION DPPA_ECOLI Dipeptide-binding protein of a transport system that can be subject to osmotic shock. DppA is also required for peptide chemotaxis. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; ISS:EcoCyc. # GO_function GO:0042277 peptide binding; IDA:EcoCyc. # GO_process GO:0006935 chemotaxis; IEA:UniProtKB-KW. # GO_process GO:0015031 protein transport; IEA:UniProtKB-KW. # GO_process GO:0015833 peptide transport; IEA:UniProtKB-KW. # GO_process GO:0055085 transmembrane transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006810 transport # GOslim_process GO:0040011 locomotion # GOslim_process GO:0055085 transmembrane transport # IntAct P23847 5 # InterPro IPR000914 SBP_5_dom # InterPro IPR023765 SBP_5_CS # InterPro IPR030678 Peptide/Ni-bd # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00324 Dipeptide transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # KEGG_Pathway ko02030 Bacterial chemotaxis # Organism DPPA_ECOLI Escherichia coli (strain K12) # PATRIC 32122558 VBIEscCol129921_3657 # PDB 1DPE X-ray; 2.00 A; A=29-535 # PDB 1DPP X-ray; 3.20 A; A/C/E/G=29-535 # PIR A39194 A39194 # PIRSF PIRSF002741 MppA # PROSITE PS01040 SBP_BACTERIAL_5 # Pfam PF00496 SBP_bac_5 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DPPA_ECOLI Periplasmic dipeptide transport protein # RefSeq NP_418001 NC_000913.3 # RefSeq WP_001222883 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial solute-binding protein 5 family. {ECO 0000305}. # SUBCELLULAR LOCATION DPPA_ECOLI Periplasm. # eggNOG COG0747 LUCA # eggNOG ENOG4105DEF Bacteria BLAST swissprot:DPPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DPPA_ECOLI BioCyc ECOL316407:JW3513-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3513-MONOMER BioCyc EcoCyc:DPPA-MONOMER http://biocyc.org/getid?id=EcoCyc:DPPA-MONOMER BioCyc MetaCyc:DPPA-MONOMER http://biocyc.org/getid?id=MetaCyc:DPPA-MONOMER COG COG0747 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0747 DIP DIP-9467N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9467N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1002/pro.5560041110 http://dx.doi.org/10.1002/pro.5560041110 DOI 10.1006/jmbi.1998.1726 http://dx.doi.org/10.1006/jmbi.1998.1726 DOI 10.1021/bi00051a006 http://dx.doi.org/10.1021/bi00051a006 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1111/j.1365-2958.1991.tb01876.x http://dx.doi.org/10.1111/j.1365-2958.1991.tb01876.x DOI 10.1111/j.1365-2958.1994.tb01340.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb01340.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L08399 http://www.ebi.ac.uk/ena/data/view/L08399 EMBL M35045 http://www.ebi.ac.uk/ena/data/view/M35045 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X58051 http://www.ebi.ac.uk/ena/data/view/X58051 EchoBASE EB0244 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0244 EcoGene EG10248 http://www.ecogene.org/geneInfo.php?eg_id=EG10248 EnsemblBacteria AAC76569 http://www.ensemblgenomes.org/id/AAC76569 EnsemblBacteria AAC76569 http://www.ensemblgenomes.org/id/AAC76569 EnsemblBacteria BAE77750 http://www.ensemblgenomes.org/id/BAE77750 EnsemblBacteria BAE77750 http://www.ensemblgenomes.org/id/BAE77750 EnsemblBacteria BAE77750 http://www.ensemblgenomes.org/id/BAE77750 EnsemblBacteria b3544 http://www.ensemblgenomes.org/id/b3544 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0042277 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042277 GO_process GO:0006935 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006935 GO_process GO:0015031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031 GO_process GO:0015833 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015833 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0040011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 948062 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948062 HOGENOM HOG000164955 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000164955&db=HOGENOM6 InParanoid P23847 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23847 IntAct P23847 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P23847* InterPro IPR000914 http://www.ebi.ac.uk/interpro/entry/IPR000914 InterPro IPR023765 http://www.ebi.ac.uk/interpro/entry/IPR023765 InterPro IPR030678 http://www.ebi.ac.uk/interpro/entry/IPR030678 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3513 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3513 KEGG_Gene eco:b3544 http://www.genome.jp/dbget-bin/www_bget?eco:b3544 KEGG_Orthology KO:K12368 http://www.genome.jp/dbget-bin/www_bget?KO:K12368 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 KEGG_Pathway ko02030 http://www.genome.jp/kegg-bin/show_pathway?ko02030 MINT MINT-1240350 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1240350 OMA HADGFTI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HADGFTI PDB 1DPE http://www.ebi.ac.uk/pdbe-srv/view/entry/1DPE PDB 1DPP http://www.ebi.ac.uk/pdbe-srv/view/entry/1DPP PDBsum 1DPE http://www.ebi.ac.uk/pdbsum/1DPE PDBsum 1DPP http://www.ebi.ac.uk/pdbsum/1DPP PROSITE PS01040 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01040 PSORT swissprot:DPPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DPPA_ECOLI PSORT-B swissprot:DPPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DPPA_ECOLI PSORT2 swissprot:DPPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DPPA_ECOLI Pfam PF00496 http://pfam.xfam.org/family/PF00496 Phobius swissprot:DPPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DPPA_ECOLI PhylomeDB P23847 http://phylomedb.org/?seqid=P23847 ProteinModelPortal P23847 http://www.proteinmodelportal.org/query/uniprot/P23847 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1702779 http://www.ncbi.nlm.nih.gov/pubmed/1702779 PubMed 1956284 http://www.ncbi.nlm.nih.gov/pubmed/1956284 PubMed 7536291 http://www.ncbi.nlm.nih.gov/pubmed/7536291 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 8527431 http://www.ncbi.nlm.nih.gov/pubmed/8527431 PubMed 8563629 http://www.ncbi.nlm.nih.gov/pubmed/8563629 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 RefSeq NP_418001 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418001 RefSeq WP_001222883 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001222883 SMR P23847 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P23847 STRING 511145.b3544 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3544&targetmode=cogs STRING COG0747 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0747&targetmode=cogs SWISS-2DPAGE P23847 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P23847 UniProtKB DPPA_ECOLI http://www.uniprot.org/uniprot/DPPA_ECOLI UniProtKB-AC P23847 http://www.uniprot.org/uniprot/P23847 charge swissprot:DPPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DPPA_ECOLI eggNOG COG0747 http://eggnogapi.embl.de/nog_data/html/tree/COG0747 eggNOG ENOG4105DEF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DEF epestfind swissprot:DPPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DPPA_ECOLI garnier swissprot:DPPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DPPA_ECOLI helixturnhelix swissprot:DPPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DPPA_ECOLI hmoment swissprot:DPPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DPPA_ECOLI iep swissprot:DPPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DPPA_ECOLI inforesidue swissprot:DPPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DPPA_ECOLI octanol swissprot:DPPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DPPA_ECOLI pepcoil swissprot:DPPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DPPA_ECOLI pepdigest swissprot:DPPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DPPA_ECOLI pepinfo swissprot:DPPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DPPA_ECOLI pepnet swissprot:DPPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DPPA_ECOLI pepstats swissprot:DPPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DPPA_ECOLI pepwheel swissprot:DPPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DPPA_ECOLI pepwindow swissprot:DPPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DPPA_ECOLI sigcleave swissprot:DPPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DPPA_ECOLI ## Database ID URL or Descriptions # AltName NANK_ECOLI ManNAc kinase # AltName NANK_ECOLI N-acetyl-D-mannosamine kinase # BIOPHYSICOCHEMICAL PROPERTIES NANK_ECOLI Kinetic parameters KM=0.36 mM for N-acyl-D-mannosamine (at 25 degrees Celsius and pH 7.6) {ECO 0000269|PubMed 15157072, ECO 0000269|PubMed 17979299}; KM=0.26 mM for ATP (at 25 degrees Celsius and pH 7.6) {ECO 0000269|PubMed 15157072, ECO 0000269|PubMed 17979299}; KM=20 mM for D-glucose (at 25 degrees Celsius and pH 7.6) {ECO 0000269|PubMed 15157072, ECO 0000269|PubMed 17979299}; KM=84 mM for D-mannose (at 25 degrees Celsius and pH 7.6) {ECO 0000269|PubMed 15157072, ECO 0000269|PubMed 17979299}; Note=Catalytic efficiency with N-acyl-D-mannosamine as substrate is 136-fold higher than that with D-glucose.; # BioGrid 4261227 316 # CATALYTIC ACTIVITY NANK_ECOLI ATP + N-acyl-D-mannosamine = ADP + N-acyl-D- mannosamine 6-phosphate. # EcoGene EG12815 nanK # FUNCTION NANK_ECOLI Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P. Has also low level glucokinase activity in vitro. {ECO 0000269|PubMed 15157072, ECO 0000269|PubMed 17979299}. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008270 zinc ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0009384 N-acylmannosamine kinase activity; IDA:EcoCyc. # GO_process GO:0006051 N-acetylmannosamine metabolic process; IEA:UniProtKB-HAMAP. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0019262 N-acetylneuraminate catabolic process; IDA:EcoCyc. # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # HAMAP MF_01234 ManNAc_kinase # InterPro IPR000600 ROK # InterPro IPR023945 ManNAc_kinase_bac # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00520 Amino sugar and nucleotide sugar metabolism # Organism NANK_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate step 2/5. # PATRIC 32121868 VBIEscCol129921_3318 # PDB 2AA4 X-ray; 2.20 A; A/B=1-289 # PIR H65113 H65113 # PROSITE PS01125 ROK # Pfam PF00480 ROK # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NANK_ECOLI N-acetylmannosamine kinase # RefSeq NP_417689 NC_000913.3 # RefSeq WP_000209011 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA58024.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ROK (NagC/XylR) family. NanK subfamily. {ECO 0000305}. # SUBUNIT Homodimer. {ECO 0000269|Ref.6}. # UniPathway UPA00629 UER00681 # eggNOG COG1940 LUCA # eggNOG ENOG41061DF Bacteria BLAST swissprot:NANK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NANK_ECOLI BioCyc ECOL316407:JW5538-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5538-MONOMER BioCyc EcoCyc:NANK-MONOMER http://biocyc.org/getid?id=EcoCyc:NANK-MONOMER BioCyc MetaCyc:NANK-MONOMER http://biocyc.org/getid?id=MetaCyc:NANK-MONOMER COG COG1940 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1940 DIP DIP-12282N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12282N DOI 10.1021/bi049424m http://dx.doi.org/10.1021/bi049424m DOI 10.1021/bi700924d http://dx.doi.org/10.1021/bi700924d DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.60 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.60 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 2.7.1.60 http://enzyme.expasy.org/EC/2.7.1.60 EchoBASE EB2666 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2666 EcoGene EG12815 http://www.ecogene.org/geneInfo.php?eg_id=EG12815 EnsemblBacteria AAC76254 http://www.ensemblgenomes.org/id/AAC76254 EnsemblBacteria AAC76254 http://www.ensemblgenomes.org/id/AAC76254 EnsemblBacteria BAE77265 http://www.ensemblgenomes.org/id/BAE77265 EnsemblBacteria BAE77265 http://www.ensemblgenomes.org/id/BAE77265 EnsemblBacteria BAE77265 http://www.ensemblgenomes.org/id/BAE77265 EnsemblBacteria b3222 http://www.ensemblgenomes.org/id/b3222 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0009384 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009384 GO_process GO:0006051 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006051 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0019262 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019262 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 947757 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947757 HAMAP MF_01234 http://hamap.expasy.org/unirule/MF_01234 HOGENOM HOG000150087 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000150087&db=HOGENOM6 InParanoid P45425 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45425 IntAct P45425 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45425* IntEnz 2.7.1.60 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.60 InterPro IPR000600 http://www.ebi.ac.uk/interpro/entry/IPR000600 InterPro IPR023945 http://www.ebi.ac.uk/interpro/entry/IPR023945 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5538 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5538 KEGG_Gene eco:b3222 http://www.genome.jp/dbget-bin/www_bget?eco:b3222 KEGG_Orthology KO:K00885 http://www.genome.jp/dbget-bin/www_bget?KO:K00885 KEGG_Pathway ko00520 http://www.genome.jp/kegg-bin/show_pathway?ko00520 KEGG_Reaction rn:R02705 http://www.genome.jp/dbget-bin/www_bget?rn:R02705 OMA YRAGDTH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YRAGDTH PDB 2AA4 http://www.ebi.ac.uk/pdbe-srv/view/entry/2AA4 PDBsum 2AA4 http://www.ebi.ac.uk/pdbsum/2AA4 PROSITE PS01125 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01125 PSORT swissprot:NANK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NANK_ECOLI PSORT-B swissprot:NANK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NANK_ECOLI PSORT2 swissprot:NANK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NANK_ECOLI Pfam PF00480 http://pfam.xfam.org/family/PF00480 Phobius swissprot:NANK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NANK_ECOLI PhylomeDB P45425 http://phylomedb.org/?seqid=P45425 ProteinModelPortal P45425 http://www.proteinmodelportal.org/query/uniprot/P45425 PubMed 15157072 http://www.ncbi.nlm.nih.gov/pubmed/15157072 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17979299 http://www.ncbi.nlm.nih.gov/pubmed/17979299 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9864311 http://www.ncbi.nlm.nih.gov/pubmed/9864311 RefSeq NP_417689 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417689 RefSeq WP_000209011 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000209011 SMR P45425 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45425 STRING 511145.b3222 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3222&targetmode=cogs STRING COG1940 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1940&targetmode=cogs UniProtKB NANK_ECOLI http://www.uniprot.org/uniprot/NANK_ECOLI UniProtKB-AC P45425 http://www.uniprot.org/uniprot/P45425 charge swissprot:NANK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NANK_ECOLI eggNOG COG1940 http://eggnogapi.embl.de/nog_data/html/tree/COG1940 eggNOG ENOG41061DF http://eggnogapi.embl.de/nog_data/html/tree/ENOG41061DF epestfind swissprot:NANK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NANK_ECOLI garnier swissprot:NANK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NANK_ECOLI helixturnhelix swissprot:NANK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NANK_ECOLI hmoment swissprot:NANK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NANK_ECOLI iep swissprot:NANK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NANK_ECOLI inforesidue swissprot:NANK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NANK_ECOLI octanol swissprot:NANK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NANK_ECOLI pepcoil swissprot:NANK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NANK_ECOLI pepdigest swissprot:NANK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NANK_ECOLI pepinfo swissprot:NANK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NANK_ECOLI pepnet swissprot:NANK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NANK_ECOLI pepstats swissprot:NANK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NANK_ECOLI pepwheel swissprot:NANK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NANK_ECOLI pepwindow swissprot:NANK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NANK_ECOLI sigcleave swissprot:NANK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NANK_ECOLI ## Database ID URL or Descriptions # AltName RMLA1_ECOLI dTDP-glucose pyrophosphorylase 1 # AltName RMLA1_ECOLI dTDP-glucose synthase 1 # BIOPHYSICOCHEMICAL PROPERTIES RMLA1_ECOLI Kinetic parameters KM=20.5 uM for dTTP {ECO 0000269|PubMed 11697907}; KM=34 uM for glucose 1-phosphate {ECO 0000269|PubMed 11697907}; KM=95 uM for dTDP-glucose {ECO 0000269|PubMed 11697907}; KM=154 uM for PPi {ECO 0000269|PubMed 11697907}; Vmax=194 umol/min/mg enzyme for the forward reaction {ECO 0000269|PubMed 11697907}; Vmax=360 umol/min/mg enzyme for the reverse reaction {ECO 0000269|PubMed 11697907}; pH dependence Optimum pH is 8.0-8.5. Active from pH 6.0 to 10.0. {ECO 0000269|PubMed 11697907}; # BioGrid 4259680 171 # CATALYTIC ACTIVITY dTTP + alpha-D-glucose 1-phosphate = diphosphate + dTDP-alpha-D-glucose. {ECO:0000269|PubMed 11697907}. # CAUTION Most extant K-12 lines do not express O-antigen because of mutations in dTDP-rhamnose biosynthetic genes or in the rhamnosyltransferase gene wbbL. {ECO 0000305}. # CDD cd02538 G1P_TT_short # COFACTOR RMLA1_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 11697907}; Note=Binds 1 Mg(2+) ion per subunit. {ECO 0000269|PubMed 11697907}; # EcoGene EG11978 rfbA # FUNCTION RMLA1_ECOLI Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. {ECO 0000269|PubMed 11697907}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0008879 glucose-1-phosphate thymidylyltransferase activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IDA:EcoCyc. # GO_process GO:0009243 O antigen biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0019305 dTDP-rhamnose biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0045226 extracellular polysaccharide biosynthetic process; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.90.550.10 -; 1. # IntAct P37744 9 # InterPro IPR005835 NTP_transferase_dom # InterPro IPR005907 G1P_thy_trans_s # InterPro IPR029044 Nucleotide-diphossugar_trans # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00521 Streptomycin biosynthesis # KEGG_Pathway ko00523 Polyketide sugar unit biosynthesis # MISCELLANEOUS Both catalyzed reactions, i.e. dTDP-glucose biosynthesis and pyrophosphorolysis, follow a sequential ordered bi-bi catalytic mechanism. {ECO:0000269|PubMed 11697907}. # Organism RMLA1_ECOLI Escherichia coli (strain K12) # PANTHER PTHR22572:SF105 PTHR22572:SF105 # PATHWAY Bacterial outer membrane biogenesis; LPS O-antigen biosynthesis. {ECO:0000269|PubMed 11697907}. # PATHWAY Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis. {ECO:0000269|PubMed 11697907}. # PATRIC 32119411 VBIEscCol129921_2116 # PDB 1H5R X-ray; 1.90 A; A/B/C/D=1-293 # PDB 1H5S X-ray; 2.30 A; A/B/C/D=1-293 # PDB 1H5T X-ray; 1.90 A; A/B/C/D=1-293 # PIR F64969 F64969 # Pfam PF00483 NTP_transferase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RMLA1_ECOLI Glucose-1-phosphate thymidylyltransferase 1 # RefSeq NP_416543 NC_000913.3 # RefSeq WP_000783975 NZ_LN832404.1 # SIMILARITY Belongs to the glucose-1-phosphate thymidylyltransferase family. {ECO 0000305}. # SUBUNIT Homotetramer. {ECO:0000269|PubMed 11697907}. # SUPFAM SSF53448 SSF53448 # TIGRFAMs TIGR01207 rmlA # eggNOG COG1209 LUCA # eggNOG ENOG4108I19 Bacteria BLAST swissprot:RMLA1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RMLA1_ECOLI BioCyc ECOL316407:JW2024-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2024-MONOMER BioCyc EcoCyc:DTDPGLUCOSEPP-MONOMER http://biocyc.org/getid?id=EcoCyc:DTDPGLUCOSEPP-MONOMER BioCyc MetaCyc:DTDPGLUCOSEPP-MONOMER http://biocyc.org/getid?id=MetaCyc:DTDPGLUCOSEPP-MONOMER COG COG1209 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1209 DOI 10.1006/jmbi.2001.5073 http://dx.doi.org/10.1006/jmbi.2001.5073 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.7.24 {ECO:0000269|PubMed:11697907} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.24 {ECO:0000269|PubMed:11697907} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U03041 http://www.ebi.ac.uk/ena/data/view/U03041 EMBL U09876 http://www.ebi.ac.uk/ena/data/view/U09876 ENZYME 2.7.7.24 {ECO:0000269|PubMed:11697907} http://enzyme.expasy.org/EC/2.7.7.24 {ECO:0000269|PubMed:11697907} EchoBASE EB1921 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1921 EcoGene EG11978 http://www.ecogene.org/geneInfo.php?eg_id=EG11978 EnsemblBacteria AAC75100 http://www.ensemblgenomes.org/id/AAC75100 EnsemblBacteria AAC75100 http://www.ensemblgenomes.org/id/AAC75100 EnsemblBacteria BAA15881 http://www.ensemblgenomes.org/id/BAA15881 EnsemblBacteria BAA15881 http://www.ensemblgenomes.org/id/BAA15881 EnsemblBacteria BAA15881 http://www.ensemblgenomes.org/id/BAA15881 EnsemblBacteria b2039 http://www.ensemblgenomes.org/id/b2039 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008879 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008879 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0009243 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009243 GO_process GO:0019305 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019305 GO_process GO:0045226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045226 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.90.550.10 http://www.cathdb.info/version/latest/superfamily/3.90.550.10 GeneID 945154 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945154 HOGENOM HOG000283473 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000283473&db=HOGENOM6 InParanoid P37744 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37744 IntAct P37744 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37744* IntEnz 2.7.7.24 {ECO:0000269|PubMed:11697907} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.24 {ECO:0000269|PubMed:11697907} InterPro IPR005835 http://www.ebi.ac.uk/interpro/entry/IPR005835 InterPro IPR005907 http://www.ebi.ac.uk/interpro/entry/IPR005907 InterPro IPR029044 http://www.ebi.ac.uk/interpro/entry/IPR029044 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2024 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2024 KEGG_Gene eco:b2039 http://www.genome.jp/dbget-bin/www_bget?eco:b2039 KEGG_Orthology KO:K00973 http://www.genome.jp/dbget-bin/www_bget?KO:K00973 KEGG_Pathway ko00521 http://www.genome.jp/kegg-bin/show_pathway?ko00521 KEGG_Pathway ko00523 http://www.genome.jp/kegg-bin/show_pathway?ko00523 KEGG_Reaction rn:R02328 http://www.genome.jp/dbget-bin/www_bget?rn:R02328 OMA PHDAEQF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PHDAEQF PANTHER PTHR22572:SF105 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22572:SF105 PDB 1H5R http://www.ebi.ac.uk/pdbe-srv/view/entry/1H5R PDB 1H5S http://www.ebi.ac.uk/pdbe-srv/view/entry/1H5S PDB 1H5T http://www.ebi.ac.uk/pdbe-srv/view/entry/1H5T PDBsum 1H5R http://www.ebi.ac.uk/pdbsum/1H5R PDBsum 1H5S http://www.ebi.ac.uk/pdbsum/1H5S PDBsum 1H5T http://www.ebi.ac.uk/pdbsum/1H5T PSORT swissprot:RMLA1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RMLA1_ECOLI PSORT-B swissprot:RMLA1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RMLA1_ECOLI PSORT2 swissprot:RMLA1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RMLA1_ECOLI Pfam PF00483 http://pfam.xfam.org/family/PF00483 Phobius swissprot:RMLA1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RMLA1_ECOLI PhylomeDB P37744 http://phylomedb.org/?seqid=P37744 ProteinModelPortal P37744 http://www.proteinmodelportal.org/query/uniprot/P37744 PubMed 11697907 http://www.ncbi.nlm.nih.gov/pubmed/11697907 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7517390 http://www.ncbi.nlm.nih.gov/pubmed/7517390 PubMed 7517391 http://www.ncbi.nlm.nih.gov/pubmed/7517391 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416543 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416543 RefSeq WP_000783975 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000783975 SMR P37744 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37744 STRING 511145.b2039 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2039&targetmode=cogs STRING COG1209 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1209&targetmode=cogs SUPFAM SSF53448 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53448 SWISS-2DPAGE P37744 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P37744 TIGRFAMs TIGR01207 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01207 UniProtKB RMLA1_ECOLI http://www.uniprot.org/uniprot/RMLA1_ECOLI UniProtKB-AC P37744 http://www.uniprot.org/uniprot/P37744 charge swissprot:RMLA1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RMLA1_ECOLI eggNOG COG1209 http://eggnogapi.embl.de/nog_data/html/tree/COG1209 eggNOG ENOG4108I19 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108I19 epestfind swissprot:RMLA1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RMLA1_ECOLI garnier swissprot:RMLA1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RMLA1_ECOLI helixturnhelix swissprot:RMLA1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RMLA1_ECOLI hmoment swissprot:RMLA1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RMLA1_ECOLI iep swissprot:RMLA1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RMLA1_ECOLI inforesidue swissprot:RMLA1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RMLA1_ECOLI octanol swissprot:RMLA1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RMLA1_ECOLI pepcoil swissprot:RMLA1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RMLA1_ECOLI pepdigest swissprot:RMLA1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RMLA1_ECOLI pepinfo swissprot:RMLA1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RMLA1_ECOLI pepnet swissprot:RMLA1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RMLA1_ECOLI pepstats swissprot:RMLA1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RMLA1_ECOLI pepwheel swissprot:RMLA1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RMLA1_ECOLI pepwindow swissprot:RMLA1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RMLA1_ECOLI sigcleave swissprot:RMLA1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RMLA1_ECOLI ## Database ID URL or Descriptions # AltName THIE_ECOLI Thiamine-phosphate pyrophosphorylase # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=1 uM for HMP-PP {ECO 0000269|Ref.5}; KM=2 uM for THZ-P {ECO:0000269|Ref.5}; # BioGrid 4259333 19 # CATALYTIC ACTIVITY 4-amino-2-methyl-5-diphosphomethylpyrimidine + 2-((2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate = diphosphate + thiamine phosphate + CO(2). {ECO 0000269|Ref.5}. # CATALYTIC ACTIVITY 4-amino-2-methyl-5-diphosphomethylpyrimidine + 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate = diphosphate + thiamine phosphate + CO(2). {ECO 0000269|Ref.5}. # CATALYTIC ACTIVITY 4-amino-2-methyl-5-diphosphomethylpyrimidine + 4-methyl-5-(2-phosphono-oxyethyl)thiazole = diphosphate + thiamine phosphate. {ECO 0000269|Ref.5}. # CDD cd00564 TMP_TenI # COFACTOR THIE_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250}; Note=Binds 1 Mg(2+) ion per subunit. {ECO 0000250}; # EcoGene EG11586 thiE # FUNCTION THIE_ECOLI Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). {ECO 0000269|PubMed 15292217, ECO 0000269|Ref.5}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0004789 thiamine-phosphate diphosphorylase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0046872 metal ion binding; IDA:EcoCyc. # GO_process GO:0009228 thiamine biosynthetic process; IDA:EcoCyc. # GO_process GO:0009229 thiamine diphosphate biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.20.20.70 -; 1. # HAMAP MF_00097 TMP_synthase # IntAct P30137 4 # InterPro IPR003733 TMP_synthase # InterPro IPR013785 Aldolase_TIM # InterPro IPR022998 ThiaminP_synth_SF # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00730 Thiamine metabolism # MASS SPECTROMETRY Mass=23014.8; Method=Electrospray; Range=1-211; Evidence={ECO:0000269|PubMed 10082377}; # Organism THIE_ECOLI Escherichia coli (strain K12) # PATHWAY Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5- diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)- thiazole step 1/1. # PATRIC 32123509 VBIEscCol129921_4107 # PIR S35118 S35118 # Pfam PF02581 TMP-TENI # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName THIE_ECOLI Thiamine-phosphate synthase # RefSeq NP_418421 NC_000913.3 # RefSeq WP_000284615 NZ_CP014272.1 # SIMILARITY Belongs to the thiamine-phosphate synthase family. {ECO 0000305}. # SUPFAM SSF51391 SSF51391 # TIGRFAMs TIGR00693 thiE # UniPathway UPA00060 UER00141 # eggNOG COG0352 LUCA # eggNOG ENOG4108UV6 Bacteria BLAST swissprot:THIE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:THIE_ECOLI BioCyc ECOL316407:JW3957-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3957-MONOMER BioCyc EcoCyc:THIE-MONOMER http://biocyc.org/getid?id=EcoCyc:THIE-MONOMER BioCyc MetaCyc:THIE-MONOMER http://biocyc.org/getid?id=MetaCyc:THIE-MONOMER COG COG0352 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0352 DIP DIP-10983N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10983N DOI 10.1002/pro.5560070815 http://dx.doi.org/10.1002/pro.5560070815 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M404284200 http://dx.doi.org/10.1074/jbc.M404284200 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.5.1.3 {ECO:0000269|Ref.5} http://www.genome.jp/dbget-bin/www_bget?EC:2.5.1.3 {ECO:0000269|Ref.5} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M88701 http://www.ebi.ac.uk/ena/data/view/M88701 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.5.1.3 {ECO:0000269|Ref.5} http://enzyme.expasy.org/EC/2.5.1.3 {ECO:0000269|Ref.5} EchoBASE EB1545 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1545 EcoGene EG11586 http://www.ecogene.org/geneInfo.php?eg_id=EG11586 EnsemblBacteria AAC76967 http://www.ensemblgenomes.org/id/AAC76967 EnsemblBacteria AAC76967 http://www.ensemblgenomes.org/id/AAC76967 EnsemblBacteria BAE77326 http://www.ensemblgenomes.org/id/BAE77326 EnsemblBacteria BAE77326 http://www.ensemblgenomes.org/id/BAE77326 EnsemblBacteria BAE77326 http://www.ensemblgenomes.org/id/BAE77326 EnsemblBacteria b3993 http://www.ensemblgenomes.org/id/b3993 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0004789 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004789 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0009228 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009228 GO_process GO:0009229 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009229 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016765 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 948491 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948491 HAMAP MF_00097 http://hamap.expasy.org/unirule/MF_00097 HOGENOM HOG000155781 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000155781&db=HOGENOM6 InParanoid P30137 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30137 IntAct P30137 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P30137* IntEnz 2.5.1.3 {ECO:0000269|Ref.5} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.5.1.3 {ECO:0000269|Ref.5} InterPro IPR003733 http://www.ebi.ac.uk/interpro/entry/IPR003733 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR022998 http://www.ebi.ac.uk/interpro/entry/IPR022998 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3957 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3957 KEGG_Gene eco:b3993 http://www.genome.jp/dbget-bin/www_bget?eco:b3993 KEGG_Orthology KO:K00788 http://www.genome.jp/dbget-bin/www_bget?KO:K00788 KEGG_Pathway ko00730 http://www.genome.jp/kegg-bin/show_pathway?ko00730 KEGG_Reaction rn:R03223 http://www.genome.jp/dbget-bin/www_bget?rn:R03223 MINT MINT-1247897 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1247897 OMA DSVEWIA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DSVEWIA PSORT swissprot:THIE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:THIE_ECOLI PSORT-B swissprot:THIE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:THIE_ECOLI PSORT2 swissprot:THIE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:THIE_ECOLI Pfam PF02581 http://pfam.xfam.org/family/PF02581 Phobius swissprot:THIE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:THIE_ECOLI PhylomeDB P30137 http://phylomedb.org/?seqid=P30137 ProteinModelPortal P30137 http://www.proteinmodelportal.org/query/uniprot/P30137 PubMed 10082377 http://www.ncbi.nlm.nih.gov/pubmed/10082377 PubMed 15292217 http://www.ncbi.nlm.nih.gov/pubmed/15292217 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 8432721 http://www.ncbi.nlm.nih.gov/pubmed/8432721 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418421 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418421 RefSeq WP_000284615 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000284615 SMR P30137 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P30137 STRING 511145.b3993 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3993&targetmode=cogs STRING COG0352 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0352&targetmode=cogs SUPFAM SSF51391 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51391 SWISS-2DPAGE P30137 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P30137 TIGRFAMs TIGR00693 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00693 UniProtKB THIE_ECOLI http://www.uniprot.org/uniprot/THIE_ECOLI UniProtKB-AC P30137 http://www.uniprot.org/uniprot/P30137 charge swissprot:THIE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:THIE_ECOLI eggNOG COG0352 http://eggnogapi.embl.de/nog_data/html/tree/COG0352 eggNOG ENOG4108UV6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UV6 epestfind swissprot:THIE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:THIE_ECOLI garnier swissprot:THIE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:THIE_ECOLI helixturnhelix swissprot:THIE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:THIE_ECOLI hmoment swissprot:THIE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:THIE_ECOLI iep swissprot:THIE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:THIE_ECOLI inforesidue swissprot:THIE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:THIE_ECOLI octanol swissprot:THIE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:THIE_ECOLI pepcoil swissprot:THIE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:THIE_ECOLI pepdigest swissprot:THIE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:THIE_ECOLI pepinfo swissprot:THIE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:THIE_ECOLI pepnet swissprot:THIE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:THIE_ECOLI pepstats swissprot:THIE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:THIE_ECOLI pepwheel swissprot:THIE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:THIE_ECOLI pepwindow swissprot:THIE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:THIE_ECOLI sigcleave swissprot:THIE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:THIE_ECOLI ## Database ID URL or Descriptions # AltName EIICB-Glc {ECO:0000303|PubMed 3023349} # AltName PTS system glucose-specific EIIB component {ECO:0000303|PubMed 3129430} # AltName PTS system glucose-specific EIIC component {ECO:0000303|PubMed 3023349} # AltName PTS system glucose-specific EIIC component {ECO:0000303|PubMed 3023349} # BioGrid 4260940 8 # CATALYTIC ACTIVITY [Protein]-N(pi)-phospho-L-histidine + D- glucose(Side 1) = [protein]-L-histidine + D-glucose 6- phosphate(Side 2). {ECO:0000269|PubMed 3129430}. # CDD cd00212 PTS_IIB_glc # DOMAIN PTGCB_ECOLI The EIIB domain is phosphorylated by phospho-EIIA on a cysteinyl or histidyl residue, depending on the transported sugar. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the EIIC domain. {ECO 0000255|PROSITE-ProRule PRU00421}. # DOMAIN PTGCB_ECOLI The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site. {ECO 0000255|PROSITE-ProRule PRU00426}. # ENZYME REGULATION Transporter activity may be inhibited by SgrT. {ECO:0000269|PubMed 16549791}. # EcoGene EG10787 ptsG # FUNCTION PTGCB_ECOLI The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II complex composed of PtsG and Crr is involved in glucose transport (PubMed 3129430, PubMed 10562420). Also functions as a chemoreceptor monitoring the environment for changes in sugar concentration and an effector modulating the activity of the transcriptional repressor Mlc (PubMed 18319344). {ECO 0000269|PubMed 10562420, ECO 0000269|PubMed 18319344, ECO 0000269|PubMed 3129430}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_function GO:0005355 glucose transmembrane transporter activity; IEA:InterPro. # GO_function GO:0008982 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:InterPro. # GO_function GO:0016301 kinase activity; IEA:UniProtKB-KW. # GO_function GO:0090564 protein-phosphocysteine-glucose phosphotransferase system transporter activity; IMP:EcoCyc. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IDA:EcoCyc. # GO_process GO:0015758 glucose transport; IMP:CACAO. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # Gene3D 3.30.1360.60 -; 1. # INDUCTION PTGCB_ECOLI The ptsG transcript is degraded under conditions of glucose-phosphate stress (due to intracellular accumulation of glucose-6-phosphate caused by disruption of glycolytic flux), or in the presence of (toxic) non-metabolizable glucose phosphate analogs due to hybridization with the small RNA sgrS (originally known as ryaA). This hybridization is sufficient to repress mRNA translation (PubMed 16549791). The hybrid is subsequently degraded by RNase E. This reduces the quantity of transporter and relieves glucose phosphate stress. {ECO 0000269|PubMed 15522088, ECO 0000269|PubMed 16549791}. # IntAct P69786 3 # InterPro IPR001996 PTS_IIB_1 # InterPro IPR003352 PTS_EIIC # InterPro IPR004719 PTS_maltose/Glc_sub_IIC # InterPro IPR011299 PTS_IIBC_glc # InterPro IPR013013 PTS_EIIC_1 # InterPro IPR018113 PTrfase_EIIB_Cys # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00265 PTS system, glucose-specific II component # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko00010 Glycolysis / Gluconeogenesis # KEGG_Pathway ko00520 Amino sugar and nucleotide sugar metabolism # KEGG_Pathway ko02060 Phosphotransferase system (PTS) # Organism PTGCB_ECOLI Escherichia coli (strain K12) # PATRIC 32117443 VBIEscCol129921_1144 # PDB 1IBA NMR; -; A=391-476 # PDB 1O2F NMR; -; B=387-476 # PDB 3BP3 X-ray; 1.65 A; A/B=396-477 # PDB 3BP8 X-ray; 2.85 A; C/D=401-475 # PIR A25336 WQEC2G # PROSITE PS01035 PTS_EIIB_TYPE_1_CYS # PROSITE PS51098 PTS_EIIB_TYPE_1 # PROSITE PS51103 PTS_EIIC_TYPE_1 # Pfam PF00367 PTS_EIIB # Pfam PF02378 PTS_EIIC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Glucose permease IIC component {ECO:0000303|PubMed 3023349} # RecName Glucose-specific phosphotransferase enzyme IIB component {ECO:0000303|PubMed 3129430} # RecName PTS system glucose-specific EIICB component {ECO:0000303|PubMed 3023349} # RefSeq NP_415619 NC_000913.3 # RefSeq WP_000475719 NZ_LN832404.1 # SIMILARITY Contains 1 PTS EIIB type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00421}. # SIMILARITY Contains 1 PTS EIIC type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00426}. # SUBCELLULAR LOCATION PTGCB_ECOLI Cell inner membrane {ECO 0000255|PROSITE- ProRule PRU00426, ECO 0000305|PubMed 3129430}; Multi-pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00426}. # SUBUNIT PTGCB_ECOLI Homodimer. {ECO 0000269|PubMed 10562420, ECO 0000269|PubMed 12716891, ECO 0000269|PubMed 18319344, ECO 0000305|PubMed 3023349}. # SUPFAM SSF55604 SSF55604 # TCDB 4.A.1.1 the pts glucose-glucoside (glc) family # TIGRFAMs TIGR00826 EIIB_glc # TIGRFAMs TIGR00852 pts-Glc # TIGRFAMs TIGR02002 PTS-II-BC-glcB # eggNOG COG1263 LUCA # eggNOG COG1264 LUCA # eggNOG ENOG4105CI1 Bacteria BLAST swissprot:PTGCB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTGCB_ECOLI BioCyc ECOL316407:JW1087-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1087-MONOMER BioCyc EcoCyc:PTSG-MONOMER http://biocyc.org/getid?id=EcoCyc:PTSG-MONOMER BioCyc MetaCyc:PTSG-MONOMER http://biocyc.org/getid?id=MetaCyc:PTSG-MONOMER COG COG1263 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1263 DIP DIP-29833N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-29833N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/abbi.1999.1458 http://dx.doi.org/10.1006/abbi.1999.1458 DOI 10.1021/bi960492l http://dx.doi.org/10.1021/bi960492l DOI 10.1021/bi963053v http://dx.doi.org/10.1021/bi963053v DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0509638103 http://dx.doi.org/10.1073/pnas.0509638103 DOI 10.1073/pnas.0709295105 http://dx.doi.org/10.1073/pnas.0709295105 DOI 10.1074/jbc.M302677200 http://dx.doi.org/10.1074/jbc.M302677200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.2004.04348.x http://dx.doi.org/10.1111/j.1365-2958.2004.04348.x DOI 10.1111/j.1432-1033.1994.tb18576.x http://dx.doi.org/10.1111/j.1432-1033.1994.tb18576.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.199 {ECO:0000269|PubMed:3129430} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.199 {ECO:0000269|PubMed:3129430} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J02618 http://www.ebi.ac.uk/ena/data/view/J02618 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.199 {ECO:0000269|PubMed:3129430} http://enzyme.expasy.org/EC/2.7.1.199 {ECO:0000269|PubMed:3129430} EchoBASE EB0780 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0780 EcoGene EG10787 http://www.ecogene.org/geneInfo.php?eg_id=EG10787 EnsemblBacteria AAC74185 http://www.ensemblgenomes.org/id/AAC74185 EnsemblBacteria AAC74185 http://www.ensemblgenomes.org/id/AAC74185 EnsemblBacteria BAA35908 http://www.ensemblgenomes.org/id/BAA35908 EnsemblBacteria BAA35908 http://www.ensemblgenomes.org/id/BAA35908 EnsemblBacteria BAA35908 http://www.ensemblgenomes.org/id/BAA35908 EnsemblBacteria b1101 http://www.ensemblgenomes.org/id/b1101 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0005355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005355 GO_function GO:0008982 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008982 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_function GO:0090564 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090564 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GO_process GO:0015758 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015758 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.30.1360.60 http://www.cathdb.info/version/latest/superfamily/3.30.1360.60 GeneID 945651 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945651 HOGENOM HOG000250993 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000250993&db=HOGENOM6 IntAct P69786 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69786* IntEnz 2.7.1.199 {ECO:0000269|PubMed:3129430} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.199 {ECO:0000269|PubMed:3129430} InterPro IPR001996 http://www.ebi.ac.uk/interpro/entry/IPR001996 InterPro IPR003352 http://www.ebi.ac.uk/interpro/entry/IPR003352 InterPro IPR004719 http://www.ebi.ac.uk/interpro/entry/IPR004719 InterPro IPR011299 http://www.ebi.ac.uk/interpro/entry/IPR011299 InterPro IPR013013 http://www.ebi.ac.uk/interpro/entry/IPR013013 InterPro IPR018113 http://www.ebi.ac.uk/interpro/entry/IPR018113 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1087 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1087 KEGG_Gene eco:b1101 http://www.genome.jp/dbget-bin/www_bget?eco:b1101 KEGG_Orthology KO:K02779 http://www.genome.jp/dbget-bin/www_bget?KO:K02779 KEGG_Pathway ko00010 http://www.genome.jp/kegg-bin/show_pathway?ko00010 KEGG_Pathway ko00520 http://www.genome.jp/kegg-bin/show_pathway?ko00520 KEGG_Pathway ko02060 http://www.genome.jp/kegg-bin/show_pathway?ko02060 KEGG_Reaction rn:R02738 http://www.genome.jp/dbget-bin/www_bget?rn:R02738 OMA MQIGEFT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MQIGEFT PDB 1IBA http://www.ebi.ac.uk/pdbe-srv/view/entry/1IBA PDB 1O2F http://www.ebi.ac.uk/pdbe-srv/view/entry/1O2F PDB 3BP3 http://www.ebi.ac.uk/pdbe-srv/view/entry/3BP3 PDB 3BP8 http://www.ebi.ac.uk/pdbe-srv/view/entry/3BP8 PDBsum 1IBA http://www.ebi.ac.uk/pdbsum/1IBA PDBsum 1O2F http://www.ebi.ac.uk/pdbsum/1O2F PDBsum 3BP3 http://www.ebi.ac.uk/pdbsum/3BP3 PDBsum 3BP8 http://www.ebi.ac.uk/pdbsum/3BP8 PROSITE PS01035 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01035 PROSITE PS51098 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51098 PROSITE PS51103 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51103 PSORT swissprot:PTGCB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTGCB_ECOLI PSORT-B swissprot:PTGCB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTGCB_ECOLI PSORT2 swissprot:PTGCB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTGCB_ECOLI Pfam PF00367 http://pfam.xfam.org/family/PF00367 Pfam PF02378 http://pfam.xfam.org/family/PF02378 Phobius swissprot:PTGCB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTGCB_ECOLI PhylomeDB P69786 http://phylomedb.org/?seqid=P69786 ProteinModelPortal P69786 http://www.proteinmodelportal.org/query/uniprot/P69786 PubMed 10562420 http://www.ncbi.nlm.nih.gov/pubmed/10562420 PubMed 12716891 http://www.ncbi.nlm.nih.gov/pubmed/12716891 PubMed 15522088 http://www.ncbi.nlm.nih.gov/pubmed/15522088 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16549791 http://www.ncbi.nlm.nih.gov/pubmed/16549791 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18319344 http://www.ncbi.nlm.nih.gov/pubmed/18319344 PubMed 3023349 http://www.ncbi.nlm.nih.gov/pubmed/3023349 PubMed 3129430 http://www.ncbi.nlm.nih.gov/pubmed/3129430 PubMed 8112346 http://www.ncbi.nlm.nih.gov/pubmed/8112346 PubMed 8505292 http://www.ncbi.nlm.nih.gov/pubmed/8505292 PubMed 8784182 http://www.ncbi.nlm.nih.gov/pubmed/8784182 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9200688 http://www.ncbi.nlm.nih.gov/pubmed/9200688 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_415619 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415619 RefSeq WP_000475719 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000475719 SMR P69786 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69786 STRING 511145.b1101 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1101&targetmode=cogs STRING COG1263 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1263&targetmode=cogs SUPFAM SSF55604 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55604 TCDB 4.A.1.1 http://www.tcdb.org/search/result.php?tc=4.A.1.1 TIGRFAMs TIGR00826 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00826 TIGRFAMs TIGR00852 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00852 TIGRFAMs TIGR02002 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02002 UniProtKB PTGCB_ECOLI http://www.uniprot.org/uniprot/PTGCB_ECOLI UniProtKB-AC P69786 http://www.uniprot.org/uniprot/P69786 charge swissprot:PTGCB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTGCB_ECOLI eggNOG COG1263 http://eggnogapi.embl.de/nog_data/html/tree/COG1263 eggNOG COG1264 http://eggnogapi.embl.de/nog_data/html/tree/COG1264 eggNOG ENOG4105CI1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CI1 epestfind swissprot:PTGCB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTGCB_ECOLI garnier swissprot:PTGCB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTGCB_ECOLI helixturnhelix swissprot:PTGCB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTGCB_ECOLI hmoment swissprot:PTGCB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTGCB_ECOLI iep swissprot:PTGCB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTGCB_ECOLI inforesidue swissprot:PTGCB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTGCB_ECOLI octanol swissprot:PTGCB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTGCB_ECOLI pepcoil swissprot:PTGCB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTGCB_ECOLI pepdigest swissprot:PTGCB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTGCB_ECOLI pepinfo swissprot:PTGCB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTGCB_ECOLI pepnet swissprot:PTGCB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTGCB_ECOLI pepstats swissprot:PTGCB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTGCB_ECOLI pepwheel swissprot:PTGCB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTGCB_ECOLI pepwindow swissprot:PTGCB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTGCB_ECOLI sigcleave swissprot:PTGCB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTGCB_ECOLI ## Database ID URL or Descriptions # BioGrid 4262309 10 # EcoGene EG10551 lysR # FUNCTION LYSR_ECOLI This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0009089 lysine biosynthetic process via diaminopimelate; IDA:EcoCyc. # GO_process GO:0010628 positive regulation of gene expression; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # IntAct P03030 6 # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR005119 LysR_subst-bd # InterPro IPR011991 WHTH_DNA-bd_dom # Organism LYSR_ECOLI Escherichia coli (strain K12) # PATRIC 32121096 VBIEscCol129921_2937 # PIR A03565 RGECK # PRINTS PR00039 HTHLYSR # PROSITE PS50931 HTH_LYSR # Pfam PF00126 HTH_1 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LYSR_ECOLI Transcriptional activator protein LysR # RefSeq NP_417316 NC_000913.3 # RefSeq WP_000741825 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lysR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00253}. # SUBCELLULAR LOCATION LYSR_ECOLI Cytoplasm. # SUPFAM SSF46785 SSF46785 # eggNOG ENOG4105RQF Bacteria # eggNOG ENOG410XT7K LUCA BLAST swissprot:LYSR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LYSR_ECOLI BioCyc ECOL316407:JW2807-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2807-MONOMER BioCyc EcoCyc:PD00360 http://biocyc.org/getid?id=EcoCyc:PD00360 DIP DIP-10135N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10135N DOI 10.1016/S0022-2836(83)80022-9 http://dx.doi.org/10.1016/S0022-2836(83)80022-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01614 http://www.ebi.ac.uk/ena/data/view/J01614 EMBL J03732 http://www.ebi.ac.uk/ena/data/view/J03732 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 EchoBASE EB0546 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0546 EcoGene EG10551 http://www.ecogene.org/geneInfo.php?eg_id=EG10551 EnsemblBacteria AAC75878 http://www.ensemblgenomes.org/id/AAC75878 EnsemblBacteria AAC75878 http://www.ensemblgenomes.org/id/AAC75878 EnsemblBacteria BAE76908 http://www.ensemblgenomes.org/id/BAE76908 EnsemblBacteria BAE76908 http://www.ensemblgenomes.org/id/BAE76908 EnsemblBacteria BAE76908 http://www.ensemblgenomes.org/id/BAE76908 EnsemblBacteria b2839 http://www.ensemblgenomes.org/id/b2839 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0009089 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009089 GO_process GO:0010628 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010628 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 947311 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947311 HOGENOM HOG000233527 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000233527&db=HOGENOM6 InParanoid P03030 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P03030 IntAct P03030 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P03030* InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW2807 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2807 KEGG_Gene eco:b2839 http://www.genome.jp/dbget-bin/www_bget?eco:b2839 MINT MINT-1320169 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1320169 OMA QMLHTSQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QMLHTSQ PRINTS PR00039 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00039 PROSITE PS50931 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50931 PSORT swissprot:LYSR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LYSR_ECOLI PSORT-B swissprot:LYSR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LYSR_ECOLI PSORT2 swissprot:LYSR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LYSR_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:LYSR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LYSR_ECOLI PhylomeDB P03030 http://phylomedb.org/?seqid=P03030 ProteinModelPortal P03030 http://www.proteinmodelportal.org/query/uniprot/P03030 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2836407 http://www.ncbi.nlm.nih.gov/pubmed/2836407 PubMed 6350602 http://www.ncbi.nlm.nih.gov/pubmed/6350602 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417316 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417316 RefSeq WP_000741825 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000741825 SMR P03030 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P03030 STRING 511145.b2839 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2839&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB LYSR_ECOLI http://www.uniprot.org/uniprot/LYSR_ECOLI UniProtKB-AC P03030 http://www.uniprot.org/uniprot/P03030 charge swissprot:LYSR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LYSR_ECOLI eggNOG ENOG4105RQF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105RQF eggNOG ENOG410XT7K http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XT7K epestfind swissprot:LYSR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LYSR_ECOLI garnier swissprot:LYSR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LYSR_ECOLI helixturnhelix swissprot:LYSR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LYSR_ECOLI hmoment swissprot:LYSR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LYSR_ECOLI iep swissprot:LYSR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LYSR_ECOLI inforesidue swissprot:LYSR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LYSR_ECOLI octanol swissprot:LYSR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LYSR_ECOLI pepcoil swissprot:LYSR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LYSR_ECOLI pepdigest swissprot:LYSR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LYSR_ECOLI pepinfo swissprot:LYSR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LYSR_ECOLI pepnet swissprot:LYSR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LYSR_ECOLI pepstats swissprot:LYSR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LYSR_ECOLI pepwheel swissprot:LYSR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LYSR_ECOLI pepwindow swissprot:LYSR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LYSR_ECOLI sigcleave swissprot:LYSR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LYSR_ECOLI ## Database ID URL or Descriptions # AltName TRAD1_ECOLI DNA transport protein TraD # FUNCTION TRAD1_ECOLI Conjugative DNA transfer (CDT) is the unidirectional transfer of ssDNA plasmid from a donor to a recipient cell. It is the central mechanism by which antibiotic resistance and virulence factors are propagated in bacterial populations. Couples the transferosome to a type IV secretion system. Probably forms a pore through which single-stranded plasmid DNA is transferred to the secretion system. The last 37 residues are important for determining plasmid specificity and transfer efficiency, with additional specificity conferred by the TraD-TraM pair. {ECO 0000269|PubMed 9811665}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0000746 conjugation; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.300 -; 2. # InterPro IPR014128 T4SS_TraD # InterPro IPR019476 T4SS_TraD_DNA-bd # InterPro IPR022585 TraD_N # InterPro IPR027417 P-loop_NTPase # Organism TRAD1_ECOLI Escherichia coli (strain K12) # PDB 3D8A X-ray; 2.55 A; S/T/U/V/W/X/Y/Z=708-717 # PIR JS0293 BVECAD # Pfam PF10412 TrwB_AAD_bind # Pfam PF12615 TraD_N # RecName TRAD1_ECOLI Coupling protein TraD # RefSeq NP_061481 NC_002483.1 # RefSeq NP_862947 NC_004998.1 # RefSeq WP_000009350 NZ_CP014273.1 # RefSeq YP_009060132 NC_024956.1 # RefSeq YP_009062862 NC_025014.1 # RefSeq YP_009068320 NC_025139.1 # RefSeq YP_009070586 NC_025175.1 # SEQUENCE CAUTION Sequence=AAC44181.2; Type=Erroneous termination; Positions=718; Note=Translated as stop.; Evidence={ECO:0000305}; Sequence=CAA30013.1; Type=Frameshift; Positions=19; Evidence={ECO 0000305}; # SIMILARITY Belongs to the TrwB coupling protein family. {ECO 0000305}. # SUBCELLULAR LOCATION TRAD1_ECOLI Cell inner membrane {ECO 0000269|PubMed 9324263}; Multi-pass membrane protein {ECO 0000269|PubMed 9324263}. # SUBUNIT TRAD1_ECOLI Interacts with relaxosome component TraM. May form a hexamer in the membrane. {ECO 0000269|PubMed 15995191, ECO 0000269|PubMed 18717787, ECO 0000269|PubMed 9324263}. # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR02759 TraD_Ftype BLAST swissprot:TRAD1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRAD1_ECOLI DIP DIP-27652N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-27652N DOI 10.1016/0022-2836(87)90452-9 http://dx.doi.org/10.1016/0022-2836(87)90452-9 DOI 10.1016/0022-2836(90)90145-C http://dx.doi.org/10.1016/0022-2836(90)90145-C DOI 10.1016/0378-1119(89)90179-0 http://dx.doi.org/10.1016/0378-1119(89)90179-0 DOI 10.1111/j.1365-2958.2008.06391.x http://dx.doi.org/10.1111/j.1365-2958.2008.06391.x DOI 10.1128/JB.187.14.4767-4773.2005 http://dx.doi.org/10.1128/JB.187.14.4767-4773.2005 EMBL AF550679 http://www.ebi.ac.uk/ena/data/view/AF550679 EMBL AJ011707 http://www.ebi.ac.uk/ena/data/view/AJ011707 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL M29254 http://www.ebi.ac.uk/ena/data/view/M29254 EMBL M54796 http://www.ebi.ac.uk/ena/data/view/M54796 EMBL U01159 http://www.ebi.ac.uk/ena/data/view/U01159 EMBL X06915 http://www.ebi.ac.uk/ena/data/view/X06915 EMBL X57428 http://www.ebi.ac.uk/ena/data/view/X57428 EMBL X57431 http://www.ebi.ac.uk/ena/data/view/X57431 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0000746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000746 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 1263585 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263585 GeneID 1446510 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1446510 GeneID 20466888 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20466888 GeneID 20468912 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20468912 GeneID 20491450 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20491450 GeneID 20492654 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20492654 InterPro IPR014128 http://www.ebi.ac.uk/interpro/entry/IPR014128 InterPro IPR019476 http://www.ebi.ac.uk/interpro/entry/IPR019476 InterPro IPR022585 http://www.ebi.ac.uk/interpro/entry/IPR022585 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 OMA SVINDKK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SVINDKK PDB 3D8A http://www.ebi.ac.uk/pdbe-srv/view/entry/3D8A PDBsum 3D8A http://www.ebi.ac.uk/pdbsum/3D8A PSORT swissprot:TRAD1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRAD1_ECOLI PSORT-B swissprot:TRAD1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRAD1_ECOLI PSORT2 swissprot:TRAD1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRAD1_ECOLI Pfam PF10412 http://pfam.xfam.org/family/PF10412 Pfam PF12615 http://pfam.xfam.org/family/PF12615 Phobius swissprot:TRAD1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRAD1_ECOLI ProteinModelPortal P09130 http://www.proteinmodelportal.org/query/uniprot/P09130 PubMed 10464182 http://www.ncbi.nlm.nih.gov/pubmed/10464182 PubMed 10498725 http://www.ncbi.nlm.nih.gov/pubmed/10498725 PubMed 15995191 http://www.ncbi.nlm.nih.gov/pubmed/15995191 PubMed 1618779 http://www.ncbi.nlm.nih.gov/pubmed/1618779 PubMed 18717787 http://www.ncbi.nlm.nih.gov/pubmed/18717787 PubMed 2163400 http://www.ncbi.nlm.nih.gov/pubmed/2163400 PubMed 2164585 http://www.ncbi.nlm.nih.gov/pubmed/2164585 PubMed 2680768 http://www.ncbi.nlm.nih.gov/pubmed/2680768 PubMed 3323526 http://www.ncbi.nlm.nih.gov/pubmed/3323526 PubMed 7915817 http://www.ncbi.nlm.nih.gov/pubmed/7915817 PubMed 9324263 http://www.ncbi.nlm.nih.gov/pubmed/9324263 PubMed 9811665 http://www.ncbi.nlm.nih.gov/pubmed/9811665 RefSeq NP_061481 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061481 RefSeq NP_862947 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_862947 RefSeq WP_000009350 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000009350 RefSeq YP_009060132 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009060132 RefSeq YP_009062862 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009062862 RefSeq YP_009068320 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009068320 RefSeq YP_009070586 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009070586 SMR P09130 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P09130 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR02759 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02759 UniProtKB TRAD1_ECOLI http://www.uniprot.org/uniprot/TRAD1_ECOLI UniProtKB-AC P09130 http://www.uniprot.org/uniprot/P09130 charge swissprot:TRAD1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRAD1_ECOLI epestfind swissprot:TRAD1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRAD1_ECOLI garnier swissprot:TRAD1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRAD1_ECOLI helixturnhelix swissprot:TRAD1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRAD1_ECOLI hmoment swissprot:TRAD1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRAD1_ECOLI iep swissprot:TRAD1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRAD1_ECOLI inforesidue swissprot:TRAD1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRAD1_ECOLI octanol swissprot:TRAD1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRAD1_ECOLI pepcoil swissprot:TRAD1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRAD1_ECOLI pepdigest swissprot:TRAD1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRAD1_ECOLI pepinfo swissprot:TRAD1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRAD1_ECOLI pepnet swissprot:TRAD1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRAD1_ECOLI pepstats swissprot:TRAD1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRAD1_ECOLI pepwheel swissprot:TRAD1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRAD1_ECOLI pepwindow swissprot:TRAD1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRAD1_ECOLI sigcleave swissprot:TRAD1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRAD1_ECOLI ## Database ID URL or Descriptions # EcoGene EG14480 yoaJ # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # INDUCTION YOAJ_ECOLI Constitutively expressed, induced by thiol oxidant diamide, slightly at 45 degrees and slightly at pH 5.5 Celsius (at protein level). {ECO 0000269|PubMed 19121005, ECO 0000269|PubMed 19734316}. # Organism YOAJ_ECOLI Escherichia coli (strain K12) # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YOAJ_ECOLI Uncharacterized protein YoaJ # RefSeq YP_002791243 NC_000913.3 # SUBCELLULAR LOCATION YOAJ_ECOLI Cell inner membrane {ECO 0000305|PubMed 19121005, ECO 0000305|PubMed 21778229}; Single-pass membrane protein {ECO 0000269|PubMed 19121005, ECO 0000269|PubMed 21778229}. Note=Some protein is also seen in the soluble fraction of the cell extracts. BLAST swissprot:YOAJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YOAJ_ECOLI BioCyc EcoCyc:MONOMER0-2875 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2875 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M111.245696 http://dx.doi.org/10.1074/jbc.M111.245696 DOI 10.1111/j.1365-2958.2008.06495.x http://dx.doi.org/10.1111/j.1365-2958.2008.06495.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00872-09 http://dx.doi.org/10.1128/JB.00872-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14480 http://www.ecogene.org/geneInfo.php?eg_id=EG14480 EnsemblBacteria ACO59995 http://www.ensemblgenomes.org/id/ACO59995 EnsemblBacteria ACO59995 http://www.ensemblgenomes.org/id/ACO59995 EnsemblBacteria b4675 http://www.ensemblgenomes.org/id/b4675 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 7751648 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7751648 KEGG_Gene eco:b4675 http://www.genome.jp/dbget-bin/www_bget?eco:b4675 PSORT swissprot:YOAJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YOAJ_ECOLI PSORT-B swissprot:YOAJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YOAJ_ECOLI PSORT2 swissprot:YOAJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YOAJ_ECOLI Phobius swissprot:YOAJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YOAJ_ECOLI PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19121005 http://www.ncbi.nlm.nih.gov/pubmed/19121005 PubMed 19734316 http://www.ncbi.nlm.nih.gov/pubmed/19734316 PubMed 21778229 http://www.ncbi.nlm.nih.gov/pubmed/21778229 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq YP_002791243 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_002791243 STRING 511145.b4675 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4675&targetmode=cogs UniProtKB YOAJ_ECOLI http://www.uniprot.org/uniprot/YOAJ_ECOLI UniProtKB-AC C1P603 http://www.uniprot.org/uniprot/C1P603 charge swissprot:YOAJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YOAJ_ECOLI epestfind swissprot:YOAJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YOAJ_ECOLI garnier swissprot:YOAJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YOAJ_ECOLI helixturnhelix swissprot:YOAJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YOAJ_ECOLI hmoment swissprot:YOAJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YOAJ_ECOLI iep swissprot:YOAJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YOAJ_ECOLI inforesidue swissprot:YOAJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YOAJ_ECOLI octanol swissprot:YOAJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YOAJ_ECOLI pepcoil swissprot:YOAJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YOAJ_ECOLI pepdigest swissprot:YOAJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YOAJ_ECOLI pepinfo swissprot:YOAJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YOAJ_ECOLI pepnet swissprot:YOAJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YOAJ_ECOLI pepstats swissprot:YOAJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YOAJ_ECOLI pepwheel swissprot:YOAJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YOAJ_ECOLI pepwindow swissprot:YOAJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YOAJ_ECOLI sigcleave swissprot:YOAJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YOAJ_ECOLI ## Database ID URL or Descriptions # AltName TIG_ECOLI PPIase # BioGrid 4259841 463 # CATALYTIC ACTIVITY Peptidylproline (omega=180) = peptidylproline (omega=0). {ECO:0000269|PubMed 8633085}. # DISRUPTION PHENOTYPE Non-essential; synthetic lethality is seen in a triple tig-dnaK-dnaJ disruption, although this depends on temperature (triple disruptions grow slowly at 20 and 34 degrees Celsius but not at all at 43 degrees) and strain background. {ECO:0000269|PubMed 14726952}. # DOMAIN TIG_ECOLI Consists of 3 domains; the N-terminus (residues 1-112) binds the ribosome, the middle domain (residues 150-246) has PPIase activity, while the discontinuous C-terminus (residues 113- 149 and 247-432) binds substrate and has intrinsic chaperone activity on its own. {ECO 0000269|PubMed 14726952, ECO 0000269|PubMed 24812405}. # EcoGene EG11003 tig # FUNCTION TIG_ECOLI Involved in protein export. Acts as a chaperone by maintaining the newly synthesized secretory and non-secretory proteins in an open conformation. Binds to 3 regions of unfolded substrate PhoA, preferring aromatic and hydrophobic residues, keeping it stretched out and unable to form aggregates (PubMed 24812405). Binds to nascent polypeptide chains via ribosomal protein L23 (PubMed 12226666). Functions as a peptidyl- prolyl cis-trans isomerase in vitro, this activity is dispensible in vivo for chaperone activity. {ECO 0000269|PubMed 12226666, ECO 0000269|PubMed 24812405, ECO 0000269|PubMed 8521806, ECO 0000269|PubMed 8633085}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0003755 peptidyl-prolyl cis-trans isomerase activity; IDA:EcoCyc. # GO_function GO:0043022 ribosome binding; IDA:EcoCyc. # GO_function GO:0044183 protein binding involved in protein folding; IDA:EcoCyc. # GO_process GO:0007049 cell cycle; IEA:UniProtKB-KW. # GO_process GO:0009408 response to heat; IMP:EcoCyc. # GO_process GO:0015031 protein transport; IEA:UniProtKB-HAMAP. # GO_process GO:0043335 protein unfolding; IDA:EcoCyc. # GO_process GO:0051083 'de novo' cotranslational protein folding; IDA:EcoCyc. # GO_process GO:0051301 cell division; IEA:UniProtKB-KW. # GO_process GO:0061077 chaperone-mediated protein folding; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0006457 protein folding # GOslim_process GO:0006810 transport # GOslim_process GO:0006950 response to stress # GOslim_process GO:0007049 cell cycle # GOslim_process GO:0008150 biological_process # GOslim_process GO:0051301 cell division # Gene3D 1.10.3120.10 -; 1. # Gene3D 3.30.70.1050 -; 1. # HAMAP MF_00303 Trigger_factor_Tig # INTERACTION TIG_ECOLI Self; NbExp=2; IntAct=EBI-544862, EBI-544862; P0A910 ompA; NbExp=3; IntAct=EBI-544862, EBI-371347; P02359 rpsG; NbExp=3; IntAct=EBI-544862, EBI-543074; # IntAct P0A850 125 # InterPro IPR001179 PPIase_FKBP_dom # InterPro IPR005215 Trig_fac # InterPro IPR008880 Trigger_fac_C # InterPro IPR008881 Trigger_fac_ribosome-bd_bac # InterPro IPR027304 Trigger_fact/SurA_dom # Organism TIG_ECOLI Escherichia coli (strain K12) # PATRIC 32116025 VBIEscCol129921_0454 # PDB 1L1P NMR; -; A=148-249 # PDB 1OMS X-ray; 2.30 A; A/B/C=1-118 # PDB 1P9Y X-ray; 2.15 A; A/B=1-118 # PDB 1W26 X-ray; 2.70 A; A/B=1-432 # PDB 1W2B X-ray; 3.50 A; 5=1-144 # PDB 2MLX NMR; -; A=1-432 # PDB 2MLY NMR; -; A=1-432 # PDB 2MLZ NMR; -; A=1-432 # PDB 2VRH EM; 19.00 A; A=1-432 # PDB 4URD EM; 7.70 A; A=1-115 # PIR D64773 D64773 # PIRSF PIRSF003095 Trigger_factor # PROSITE PS50059 FKBP_PPIASE # Pfam PF00254 FKBP_C # Pfam PF05697 Trigger_N # Pfam PF05698 Trigger_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TIG_ECOLI Trigger factor # RefSeq NP_414970 NC_000913.3 # RefSeq WP_001198386 NZ_LN832404.1 # SIMILARITY Belongs to the FKBP-type PPIase family. Tig subfamily. {ECO 0000305}. # SIMILARITY Contains 1 PPIase FKBP-type domain. {ECO 0000305}. # SUBCELLULAR LOCATION TIG_ECOLI Cytoplasm {ECO 0000269|PubMed 8633085}. Note=About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm. {ECO 0000269|PubMed 8633085}. # SUBUNIT TIG_ECOLI Homodimer and monomer. In vivo most of the ribosomes are in complex with monomeric TF (PubMed 12452438); binding as a dimer has also been suggested (PubMed 12581648). Uncomplexed TF is in a monomer-dimer equilibrium with approximately two thirds of TF existing in a dimeric state; binding to substrate PhoA induces monomerization, 3 TF monomers bind somewhat independently to a single substrate molecule (PubMed 12452438, PubMed 24812405). TF and SRP can simultaneously bind to ribosomes; TF binding is abolished when SRP is bound to FtsY in the presence of a non- hydrolyzable GTP analog (PubMed 15148364). Contacts ribosomal proteins L23 and L29 (PubMed 12226666). {ECO 0000269|PubMed 12226666, ECO 0000269|PubMed 12452438, ECO 0000269|PubMed 12581648, ECO 0000269|PubMed 15148364, ECO 0000269|PubMed 24812405}. # SUPFAM SSF102735 SSF102735 # SUPFAM SSF109998 SSF109998 # TIGRFAMs TIGR00115 tig # eggNOG COG0544 LUCA # eggNOG ENOG4105DEA Bacteria BLAST swissprot:TIG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TIG_ECOLI BioCyc ECOL316407:JW0426-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0426-MONOMER BioCyc EcoCyc:EG11003-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11003-MONOMER BioCyc MetaCyc:EG11003-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11003-MONOMER COG COG0544 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0544 DIP DIP-36226N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36226N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1016/0014-5793(96)00282-7 http://dx.doi.org/10.1016/0014-5793(96)00282-7 DOI 10.1016/0092-8674(88)90115-8 http://dx.doi.org/10.1016/0092-8674(88)90115-8 DOI 10.1016/S0022-2836(02)01436-5 http://dx.doi.org/10.1016/S0022-2836(02)01436-5 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature01047 http://dx.doi.org/10.1038/nature01047 DOI 10.1038/sj.embor.7400067 http://dx.doi.org/10.1038/sj.embor.7400067 DOI 10.1073/pnas.0402231101 http://dx.doi.org/10.1073/pnas.0402231101 DOI 10.1073/pnas.93.9.4437 http://dx.doi.org/10.1073/pnas.93.9.4437 DOI 10.1083/jcb.200302130 http://dx.doi.org/10.1083/jcb.200302130 DOI 10.1126/science.1250494 http://dx.doi.org/10.1126/science.1250494 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1515/BC.2002.182 http://dx.doi.org/10.1515/BC.2002.182 EC_number EC:5.2.1.8 {ECO:0000269|PubMed:8633085} http://www.genome.jp/dbget-bin/www_bget?EC:5.2.1.8 {ECO:0000269|PubMed:8633085} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J05534 http://www.ebi.ac.uk/ena/data/view/J05534 EMBL M34066 http://www.ebi.ac.uk/ena/data/view/M34066 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL X17642 http://www.ebi.ac.uk/ena/data/view/X17642 ENZYME 5.2.1.8 {ECO:0000269|PubMed:8633085} http://enzyme.expasy.org/EC/5.2.1.8 {ECO:0000269|PubMed:8633085} EchoBASE EB0996 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0996 EcoGene EG11003 http://www.ecogene.org/geneInfo.php?eg_id=EG11003 EnsemblBacteria AAC73539 http://www.ensemblgenomes.org/id/AAC73539 EnsemblBacteria AAC73539 http://www.ensemblgenomes.org/id/AAC73539 EnsemblBacteria BAE76216 http://www.ensemblgenomes.org/id/BAE76216 EnsemblBacteria BAE76216 http://www.ensemblgenomes.org/id/BAE76216 EnsemblBacteria BAE76216 http://www.ensemblgenomes.org/id/BAE76216 EnsemblBacteria b0436 http://www.ensemblgenomes.org/id/b0436 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0003755 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003755 GO_function GO:0043022 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043022 GO_function GO:0044183 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044183 GO_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GO_process GO:0015031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031 GO_process GO:0043335 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043335 GO_process GO:0051083 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051083 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GO_process GO:0061077 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061077 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 Gene3D 1.10.3120.10 http://www.cathdb.info/version/latest/superfamily/1.10.3120.10 Gene3D 3.30.70.1050 http://www.cathdb.info/version/latest/superfamily/3.30.70.1050 GeneID 945081 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945081 HAMAP MF_00303 http://hamap.expasy.org/unirule/MF_00303 HOGENOM HOG000218239 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218239&db=HOGENOM6 InParanoid P0A850 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A850 IntAct P0A850 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A850* IntEnz 5.2.1.8 {ECO:0000269|PubMed:8633085} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.2.1.8 {ECO:0000269|PubMed:8633085} InterPro IPR001179 http://www.ebi.ac.uk/interpro/entry/IPR001179 InterPro IPR005215 http://www.ebi.ac.uk/interpro/entry/IPR005215 InterPro IPR008880 http://www.ebi.ac.uk/interpro/entry/IPR008880 InterPro IPR008881 http://www.ebi.ac.uk/interpro/entry/IPR008881 InterPro IPR027304 http://www.ebi.ac.uk/interpro/entry/IPR027304 KEGG_Gene ecj:JW0426 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0426 KEGG_Gene eco:b0436 http://www.genome.jp/dbget-bin/www_bget?eco:b0436 KEGG_Orthology KO:K03545 http://www.genome.jp/dbget-bin/www_bget?KO:K03545 MINT MINT-1225982 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1225982 OMA KAQNDDK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KAQNDDK PDB 1L1P http://www.ebi.ac.uk/pdbe-srv/view/entry/1L1P PDB 1OMS http://www.ebi.ac.uk/pdbe-srv/view/entry/1OMS PDB 1P9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/1P9Y PDB 1W26 http://www.ebi.ac.uk/pdbe-srv/view/entry/1W26 PDB 1W2B http://www.ebi.ac.uk/pdbe-srv/view/entry/1W2B PDB 2MLX http://www.ebi.ac.uk/pdbe-srv/view/entry/2MLX PDB 2MLY http://www.ebi.ac.uk/pdbe-srv/view/entry/2MLY PDB 2MLZ http://www.ebi.ac.uk/pdbe-srv/view/entry/2MLZ PDB 2VRH http://www.ebi.ac.uk/pdbe-srv/view/entry/2VRH PDB 4URD http://www.ebi.ac.uk/pdbe-srv/view/entry/4URD PDBsum 1L1P http://www.ebi.ac.uk/pdbsum/1L1P PDBsum 1OMS http://www.ebi.ac.uk/pdbsum/1OMS PDBsum 1P9Y http://www.ebi.ac.uk/pdbsum/1P9Y PDBsum 1W26 http://www.ebi.ac.uk/pdbsum/1W26 PDBsum 1W2B http://www.ebi.ac.uk/pdbsum/1W2B PDBsum 2MLX http://www.ebi.ac.uk/pdbsum/2MLX PDBsum 2MLY http://www.ebi.ac.uk/pdbsum/2MLY PDBsum 2MLZ http://www.ebi.ac.uk/pdbsum/2MLZ PDBsum 2VRH http://www.ebi.ac.uk/pdbsum/2VRH PDBsum 4URD http://www.ebi.ac.uk/pdbsum/4URD PROSITE PS50059 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50059 PSORT swissprot:TIG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TIG_ECOLI PSORT-B swissprot:TIG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TIG_ECOLI PSORT2 swissprot:TIG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TIG_ECOLI Pfam PF00254 http://pfam.xfam.org/family/PF00254 Pfam PF05697 http://pfam.xfam.org/family/PF05697 Pfam PF05698 http://pfam.xfam.org/family/PF05698 Phobius swissprot:TIG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TIG_ECOLI PhylomeDB P0A850 http://phylomedb.org/?seqid=P0A850 ProteinModelPortal P0A850 http://www.proteinmodelportal.org/query/uniprot/P0A850 PubMed 12226666 http://www.ncbi.nlm.nih.gov/pubmed/12226666 PubMed 12452438 http://www.ncbi.nlm.nih.gov/pubmed/12452438 PubMed 12581648 http://www.ncbi.nlm.nih.gov/pubmed/12581648 PubMed 12756233 http://www.ncbi.nlm.nih.gov/pubmed/12756233 PubMed 14726952 http://www.ncbi.nlm.nih.gov/pubmed/14726952 PubMed 15148364 http://www.ncbi.nlm.nih.gov/pubmed/15148364 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2197275 http://www.ncbi.nlm.nih.gov/pubmed/2197275 PubMed 2211496 http://www.ncbi.nlm.nih.gov/pubmed/2211496 PubMed 24812405 http://www.ncbi.nlm.nih.gov/pubmed/24812405 PubMed 2684651 http://www.ncbi.nlm.nih.gov/pubmed/2684651 PubMed 2843289 http://www.ncbi.nlm.nih.gov/pubmed/2843289 PubMed 8521806 http://www.ncbi.nlm.nih.gov/pubmed/8521806 PubMed 8612805 http://www.ncbi.nlm.nih.gov/pubmed/8612805 PubMed 8633085 http://www.ncbi.nlm.nih.gov/pubmed/8633085 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_414970 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414970 RefSeq WP_001198386 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001198386 SMR P0A850 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A850 STRING 511145.b0436 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0436&targetmode=cogs STRING COG0544 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0544&targetmode=cogs SUPFAM SSF102735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF102735 SUPFAM SSF109998 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF109998 SWISS-2DPAGE P0A850 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A850 TIGRFAMs TIGR00115 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00115 UniProtKB TIG_ECOLI http://www.uniprot.org/uniprot/TIG_ECOLI UniProtKB-AC P0A850 http://www.uniprot.org/uniprot/P0A850 charge swissprot:TIG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TIG_ECOLI eggNOG COG0544 http://eggnogapi.embl.de/nog_data/html/tree/COG0544 eggNOG ENOG4105DEA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DEA epestfind swissprot:TIG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TIG_ECOLI garnier swissprot:TIG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TIG_ECOLI helixturnhelix swissprot:TIG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TIG_ECOLI hmoment swissprot:TIG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TIG_ECOLI iep swissprot:TIG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TIG_ECOLI inforesidue swissprot:TIG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TIG_ECOLI octanol swissprot:TIG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TIG_ECOLI pepcoil swissprot:TIG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TIG_ECOLI pepdigest swissprot:TIG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TIG_ECOLI pepinfo swissprot:TIG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TIG_ECOLI pepnet swissprot:TIG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TIG_ECOLI pepstats swissprot:TIG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TIG_ECOLI pepwheel swissprot:TIG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TIG_ECOLI pepwindow swissprot:TIG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TIG_ECOLI sigcleave swissprot:TIG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TIG_ECOLI ## Database ID URL or Descriptions # BioGrid 4259621 207 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG12947 yrhA # Organism YRHA_ECOLI Escherichia coli (strain K12) # PATRIC 48667216 VBIEscCol107702_3873 # PIR F65140 F65140 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YRHA_ECOLI Putative uncharacterized protein YrhA # RefSeq WP_000988497 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAE77850.1; Type=Erroneous initiation; Evidence={ECO 0000305}; BLAST swissprot:YRHA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YRHA_ECOLI BioCyc ECOL316407:JW5864-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5864-MONOMER BioCyc EcoCyc:G7760-MONOMER http://biocyc.org/getid?id=EcoCyc:G7760-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2781 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2781 EcoGene EG12947 http://www.ecogene.org/geneInfo.php?eg_id=EG12947 EnsemblBacteria BAE77850 http://www.ensemblgenomes.org/id/BAE77850 EnsemblBacteria BAE77850 http://www.ensemblgenomes.org/id/BAE77850 EnsemblBacteria BAE77850 http://www.ensemblgenomes.org/id/BAE77850 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv HOGENOM HOG000125653 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125653&db=HOGENOM6 KEGG_Gene ecj:JW5864 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5864 PSORT swissprot:YRHA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YRHA_ECOLI PSORT-B swissprot:YRHA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YRHA_ECOLI PSORT2 swissprot:YRHA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YRHA_ECOLI Phobius swissprot:YRHA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YRHA_ECOLI ProteinModelPortal P46856 http://www.proteinmodelportal.org/query/uniprot/P46856 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000988497 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000988497 STRING 316407.85676600 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85676600&targetmode=cogs UniProtKB YRHA_ECOLI http://www.uniprot.org/uniprot/YRHA_ECOLI UniProtKB-AC P46856 http://www.uniprot.org/uniprot/P46856 charge swissprot:YRHA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YRHA_ECOLI epestfind swissprot:YRHA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YRHA_ECOLI garnier swissprot:YRHA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YRHA_ECOLI helixturnhelix swissprot:YRHA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YRHA_ECOLI hmoment swissprot:YRHA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YRHA_ECOLI iep swissprot:YRHA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YRHA_ECOLI inforesidue swissprot:YRHA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YRHA_ECOLI octanol swissprot:YRHA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YRHA_ECOLI pepcoil swissprot:YRHA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YRHA_ECOLI pepdigest swissprot:YRHA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YRHA_ECOLI pepinfo swissprot:YRHA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YRHA_ECOLI pepnet swissprot:YRHA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YRHA_ECOLI pepstats swissprot:YRHA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YRHA_ECOLI pepwheel swissprot:YRHA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YRHA_ECOLI pepwindow swissprot:YRHA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YRHA_ECOLI sigcleave swissprot:YRHA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YRHA_ECOLI ## Database ID URL or Descriptions # AltName NHAB_ECOLI Sodium/proton antiporter NhaB # BIOPHYSICOCHEMICAL PROPERTIES NHAB_ECOLI Kinetic parameters KM=16.66 mM for Na(+) (at pH 7.2) {ECO 0000269|PubMed 7929345}; KM=3.44 mM for Na(+) (at pH 7.6) {ECO 0000269|PubMed 7929345}; KM=1.53 mM for Na(+) (at pH 8.5) {ECO 0000269|PubMed 7929345}; Vmax=107 umol/min/mg enzyme (at pH 7.2) {ECO 0000269|PubMed 7929345}; Vmax=67.5 umol/min/mg enzyme (at pH 7.6) {ECO 0000269|PubMed 7929345}; Vmax=87.8 umol/min/mg enzyme (at pH 8.5) {ECO 0000269|PubMed 7929345}; # BioGrid 4260101 13 # EcoGene EG11392 nhaB # FUNCTION NHAB_ECOLI Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. Catalyzes the exchange of 3 H(+) per 2 Na(+). Has a high affinity for sodium, but can also transport lithium. Activity is weakly pH-dependent. Essential for regulation of intracellular pH under alkaline conditions. {ECO 0000269|PubMed 7822245, ECO 0000269|PubMed 7929345, ECO 0000269|PubMed 8019504, ECO 0000269|PubMed 8093613}. # GO_component GO:0005886 plasma membrane; IDA:EcoliWiki. # GO_component GO:0016021 integral component of membrane; IBA:GO_Central. # GO_function NHAB_ECOLI GO 0015385 sodium proton antiporter activity; IDA EcoliWiki. # GO_function NHAB_ECOLI GO 0015491 cation cation antiporter activity; IMP EcoCyc. # GO_process GO:0006814 sodium ion transport; IMP:EcoCyc. # GO_process GO:0010226 response to lithium ion; IGI:EcoliWiki. # GO_process GO:0015992 proton transport; IMP:EcoCyc. # GO_process GO:0051452 intracellular pH reduction; IMP:EcoCyc. # GO_process GO:0098656 anion transmembrane transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # GOslim_process GO:0042592 homeostatic process # GOslim_process GO:0055085 transmembrane transport # HAMAP MF_01599 NhaB # InterPro IPR004671 Na+/H+_antiporter_NhaB # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko00680 Methane metabolism # Organism NHAB_ECOLI Escherichia coli (strain K12) # PATRIC 32117618 VBIEscCol129921_1231 # PIR G64864 G64864 # Pfam PF06450 NhaB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NHAB_ECOLI Na(+)/H(+) antiporter NhaB # RefSeq NP_415704 NC_000913.3 # RefSeq WP_000406391 NZ_LN832404.1 # SIMILARITY Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family. {ECO 0000305}. # SUBCELLULAR LOCATION NHAB_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # TCDB 2.A.34.1:the nhab na(+) h(+) antiporter (nhab) family # TIGRFAMs TIGR00774 NhaB # eggNOG COG3067 LUCA # eggNOG ENOG4105DKR Bacteria BLAST swissprot:NHAB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NHAB_ECOLI BioCyc ECOL316407:JW1175-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1175-MONOMER BioCyc EcoCyc:NHAB-MONOMER http://biocyc.org/getid?id=EcoCyc:NHAB-MONOMER BioCyc MetaCyc:NHAB-MONOMER http://biocyc.org/getid?id=MetaCyc:NHAB-MONOMER COG COG3067 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3067 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1248/bpb.17.395 http://dx.doi.org/10.1248/bpb.17.395 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M83655 http://www.ebi.ac.uk/ena/data/view/M83655 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1365 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1365 EcoGene EG11392 http://www.ecogene.org/geneInfo.php?eg_id=EG11392 EnsemblBacteria AAC74270 http://www.ensemblgenomes.org/id/AAC74270 EnsemblBacteria AAC74270 http://www.ensemblgenomes.org/id/AAC74270 EnsemblBacteria BAA36033 http://www.ensemblgenomes.org/id/BAA36033 EnsemblBacteria BAA36033 http://www.ensemblgenomes.org/id/BAA36033 EnsemblBacteria BAA36033 http://www.ensemblgenomes.org/id/BAA36033 EnsemblBacteria b1186 http://www.ensemblgenomes.org/id/b1186 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015385 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015385 GO_function GO:0015491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015491 GO_process GO:0006814 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814 GO_process GO:0010226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010226 GO_process GO:0015992 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015992 GO_process GO:0051452 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051452 GO_process GO:0098656 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098656 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 944822 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944822 HAMAP MF_01599 http://hamap.expasy.org/unirule/MF_01599 HOGENOM HOG000218133 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218133&db=HOGENOM6 InParanoid P0AFA7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFA7 InterPro IPR004671 http://www.ebi.ac.uk/interpro/entry/IPR004671 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW1175 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1175 KEGG_Gene eco:b1186 http://www.genome.jp/dbget-bin/www_bget?eco:b1186 KEGG_Orthology KO:K03314 http://www.genome.jp/dbget-bin/www_bget?KO:K03314 KEGG_Pathway ko00680 http://www.genome.jp/kegg-bin/show_pathway?ko00680 OMA QFEMLAV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QFEMLAV PSORT swissprot:NHAB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NHAB_ECOLI PSORT-B swissprot:NHAB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NHAB_ECOLI PSORT2 swissprot:NHAB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NHAB_ECOLI Pfam PF06450 http://pfam.xfam.org/family/PF06450 Phobius swissprot:NHAB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NHAB_ECOLI ProteinModelPortal P0AFA7 http://www.proteinmodelportal.org/query/uniprot/P0AFA7 PubMed 1317851 http://www.ncbi.nlm.nih.gov/pubmed/1317851 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7822245 http://www.ncbi.nlm.nih.gov/pubmed/7822245 PubMed 7929345 http://www.ncbi.nlm.nih.gov/pubmed/7929345 PubMed 8019504 http://www.ncbi.nlm.nih.gov/pubmed/8019504 PubMed 8093613 http://www.ncbi.nlm.nih.gov/pubmed/8093613 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415704 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415704 RefSeq WP_000406391 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000406391 STRING 511145.b1186 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1186&targetmode=cogs STRING COG3067 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3067&targetmode=cogs TCDB 2.A.34.1 http://www.tcdb.org/search/result.php?tc=2.A.34.1 TIGRFAMs TIGR00774 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00774 UniProtKB NHAB_ECOLI http://www.uniprot.org/uniprot/NHAB_ECOLI UniProtKB-AC P0AFA7 http://www.uniprot.org/uniprot/P0AFA7 charge swissprot:NHAB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NHAB_ECOLI eggNOG COG3067 http://eggnogapi.embl.de/nog_data/html/tree/COG3067 eggNOG ENOG4105DKR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DKR epestfind swissprot:NHAB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NHAB_ECOLI garnier swissprot:NHAB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NHAB_ECOLI helixturnhelix swissprot:NHAB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NHAB_ECOLI hmoment swissprot:NHAB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NHAB_ECOLI iep swissprot:NHAB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NHAB_ECOLI inforesidue swissprot:NHAB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NHAB_ECOLI octanol swissprot:NHAB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NHAB_ECOLI pepcoil swissprot:NHAB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NHAB_ECOLI pepdigest swissprot:NHAB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NHAB_ECOLI pepinfo swissprot:NHAB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NHAB_ECOLI pepnet swissprot:NHAB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NHAB_ECOLI pepstats swissprot:NHAB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NHAB_ECOLI pepwheel swissprot:NHAB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NHAB_ECOLI pepwindow swissprot:NHAB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NHAB_ECOLI sigcleave swissprot:NHAB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NHAB_ECOLI ## Database ID URL or Descriptions # AltName Glycine acetyltransferase {ECO:0000255|HAMAP-Rule MF_00985} # BRENDA 2.3.1.29 2026 # BioGrid 4263301 13 # CATALYTIC ACTIVITY KBL_ECOLI Acetyl-CoA + glycine = CoA + 2-amino-3- oxobutanoate. {ECO 0000255|HAMAP-Rule MF_00985, ECO 0000269|PubMed 2104756}. # COFACTOR KBL_ECOLI Name=pyridoxal 5'-phosphate; Xref=ChEBI CHEBI 597326; Evidence={ECO 0000255|HAMAP-Rule MF_00985, ECO 0000269|PubMed 2104756}; Note=Binds 1 pyridoxal phosphate per subunit. {ECO 0000255|HAMAP- Rule MF_00985, ECO 0000269|PubMed 2104756}; # EcoGene EG10512 kbl # FUNCTION KBL_ECOLI Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. {ECO 0000255|HAMAP-Rule MF_00985, ECO 0000269|PubMed 2104756}. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008890 glycine C-acetyltransferase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0016874 ligase activity; IDA:EcoliWiki. # GO_function GO:0030170 pyridoxal phosphate binding; IDA:EcoliWiki. # GO_function GO:0046872 metal ion binding; IDA:EcoliWiki. # GO_process GO:0009058 biosynthetic process; IEA:InterPro. # GO_process GO:0019518 L-threonine catabolic process to glycine; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.640.10 -; 1. # Gene3D 3.90.1150.10 -; 1. # HAMAP MF_00985 2am3keto_CoA_ligase # IntAct P0AB77 6 # InterPro IPR001917 Aminotrans_II_pyridoxalP_BS # InterPro IPR004839 Aminotransferase_I/II # InterPro IPR011282 2am3keto_CoA_ligase # InterPro IPR015421 PyrdxlP-dep_Trfase_major_sub1 # InterPro IPR015422 PyrdxlP-dep_Trfase_major_sub2 # InterPro IPR015424 PyrdxlP-dep_Trfase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01007 Amino acid related enzymes # KEGG_Pathway ko00260 Glycine, serine and threonine metabolism # Organism KBL_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 2/2. {ECO 0000255|HAMAP-Rule:MF_00985}. # PATRIC 32122721 VBIEscCol129921_3737 # PDB 1FC4 X-ray; 2.00 A; A/B=1-398 # PIR C65162 XUECGA # PROSITE PS00599 AA_TRANSFER_CLASS_2 # Pfam PF00155 Aminotran_1_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 2-amino-3-ketobutyrate coenzyme A ligase {ECO:0000255|HAMAP-Rule MF_00985} # RefSeq NP_418074 NC_000913.3 # RefSeq WP_001213834 NZ_LN832404.1 # SIMILARITY Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. {ECO:0000255|HAMAP-Rule MF_00985}. # SUBUNIT KBL_ECOLI Homodimer. {ECO 0000255|HAMAP-Rule MF_00985, ECO 0000269|PubMed 11318637, ECO 0000269|PubMed 2104756}. # SUPFAM SSF53383 SSF53383 # TIGRFAMs TIGR01822 2am3keto_CoA # UniPathway UPA00046 UER00506 # eggNOG COG0156 LUCA # eggNOG ENOG4107EEK Bacteria BLAST swissprot:KBL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:KBL_ECOLI BioCyc ECOL316407:JW3592-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3592-MONOMER BioCyc EcoCyc:AKBLIG-MONOMER http://biocyc.org/getid?id=EcoCyc:AKBLIG-MONOMER BioCyc MetaCyc:AKBLIG-MONOMER http://biocyc.org/getid?id=MetaCyc:AKBLIG-MONOMER COG COG0156 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0156 DIP DIP-48030N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48030N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0167-4838(90)90097-Y http://dx.doi.org/10.1016/0167-4838(90)90097-Y DOI 10.1021/bi002204y http://dx.doi.org/10.1021/bi002204y DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/16.8.3586 http://dx.doi.org/10.1093/nar/16.8.3586 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.29 {ECO:0000255|HAMAP-Rule:MF_00985} http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.29 {ECO:0000255|HAMAP-Rule:MF_00985} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X06690 http://www.ebi.ac.uk/ena/data/view/X06690 ENZYME 2.3.1.29 {ECO:0000255|HAMAP-Rule:MF_00985} http://enzyme.expasy.org/EC/2.3.1.29 {ECO:0000255|HAMAP-Rule:MF_00985} EchoBASE EB0507 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0507 EcoGene EG10512 http://www.ecogene.org/geneInfo.php?eg_id=EG10512 EnsemblBacteria AAC76641 http://www.ensemblgenomes.org/id/AAC76641 EnsemblBacteria AAC76641 http://www.ensemblgenomes.org/id/AAC76641 EnsemblBacteria BAE77675 http://www.ensemblgenomes.org/id/BAE77675 EnsemblBacteria BAE77675 http://www.ensemblgenomes.org/id/BAE77675 EnsemblBacteria BAE77675 http://www.ensemblgenomes.org/id/BAE77675 EnsemblBacteria b3617 http://www.ensemblgenomes.org/id/b3617 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008890 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008890 GO_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GO_process GO:0019518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019518 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.640.10 http://www.cathdb.info/version/latest/superfamily/3.40.640.10 Gene3D 3.90.1150.10 http://www.cathdb.info/version/latest/superfamily/3.90.1150.10 GeneID 948138 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948138 HAMAP MF_00985 http://hamap.expasy.org/unirule/MF_00985 HOGENOM HOG000221022 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000221022&db=HOGENOM6 InParanoid P0AB77 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AB77 IntAct P0AB77 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AB77* IntEnz 2.3.1.29 {ECO:0000255|HAMAP-Rule:MF_00985} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.29 {ECO:0000255|HAMAP-Rule:MF_00985} InterPro IPR001917 http://www.ebi.ac.uk/interpro/entry/IPR001917 InterPro IPR004839 http://www.ebi.ac.uk/interpro/entry/IPR004839 InterPro IPR011282 http://www.ebi.ac.uk/interpro/entry/IPR011282 InterPro IPR015421 http://www.ebi.ac.uk/interpro/entry/IPR015421 InterPro IPR015422 http://www.ebi.ac.uk/interpro/entry/IPR015422 InterPro IPR015424 http://www.ebi.ac.uk/interpro/entry/IPR015424 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Gene ecj:JW3592 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3592 KEGG_Gene eco:b3617 http://www.genome.jp/dbget-bin/www_bget?eco:b3617 KEGG_Orthology KO:K00639 http://www.genome.jp/dbget-bin/www_bget?KO:K00639 KEGG_Pathway ko00260 http://www.genome.jp/kegg-bin/show_pathway?ko00260 KEGG_Reaction rn:R00371 http://www.genome.jp/dbget-bin/www_bget?rn:R00371 MINT MINT-1315923 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1315923 OMA QYVIDAF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QYVIDAF PDB 1FC4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1FC4 PDBsum 1FC4 http://www.ebi.ac.uk/pdbsum/1FC4 PROSITE PS00599 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00599 PSORT swissprot:KBL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:KBL_ECOLI PSORT-B swissprot:KBL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:KBL_ECOLI PSORT2 swissprot:KBL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:KBL_ECOLI Pfam PF00155 http://pfam.xfam.org/family/PF00155 Phobius swissprot:KBL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:KBL_ECOLI PhylomeDB P0AB77 http://phylomedb.org/?seqid=P0AB77 ProteinModelPortal P0AB77 http://www.proteinmodelportal.org/query/uniprot/P0AB77 PubMed 11318637 http://www.ncbi.nlm.nih.gov/pubmed/11318637 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2104756 http://www.ncbi.nlm.nih.gov/pubmed/2104756 PubMed 3117785 http://www.ncbi.nlm.nih.gov/pubmed/3117785 PubMed 3287333 http://www.ncbi.nlm.nih.gov/pubmed/3287333 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_418074 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418074 RefSeq WP_001213834 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001213834 SMR P0AB77 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AB77 STRING 511145.b3617 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3617&targetmode=cogs STRING COG0156 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0156&targetmode=cogs SUPFAM SSF53383 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53383 TIGRFAMs TIGR01822 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01822 UniProtKB KBL_ECOLI http://www.uniprot.org/uniprot/KBL_ECOLI UniProtKB-AC P0AB77 http://www.uniprot.org/uniprot/P0AB77 charge swissprot:KBL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:KBL_ECOLI eggNOG COG0156 http://eggnogapi.embl.de/nog_data/html/tree/COG0156 eggNOG ENOG4107EEK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107EEK epestfind swissprot:KBL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:KBL_ECOLI garnier swissprot:KBL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:KBL_ECOLI helixturnhelix swissprot:KBL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:KBL_ECOLI hmoment swissprot:KBL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:KBL_ECOLI iep swissprot:KBL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:KBL_ECOLI inforesidue swissprot:KBL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:KBL_ECOLI octanol swissprot:KBL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:KBL_ECOLI pepcoil swissprot:KBL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:KBL_ECOLI pepdigest swissprot:KBL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:KBL_ECOLI pepinfo swissprot:KBL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:KBL_ECOLI pepnet swissprot:KBL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:KBL_ECOLI pepstats swissprot:KBL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:KBL_ECOLI pepwheel swissprot:KBL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:KBL_ECOLI pepwindow swissprot:KBL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:KBL_ECOLI sigcleave swissprot:KBL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:KBL_ECOLI ## Database ID URL or Descriptions # AltName UDP-ManNAc 6-dehydrogenase {ECO:0000255|HAMAP-Rule MF_02029, ECO:0000305} # BIOPHYSICOCHEMICAL PROPERTIES WECC_ECOLI Kinetic parameters KM=0.22 mM for UDP-ManNAc (in the presence of 1 mM N- acetylglucosamine-1-P) {ECO 0000269|PubMed 381306}; KM=0.11 mM for UDP-ManNAc (in the presence of 150 mM KCl) {ECO 0000269|PubMed 381306}; KM=0.38 mM for UDP-ManNAc (in the absence of activators) {ECO 0000269|PubMed 381306}; KM=0.21 mM for NAD(+) {ECO 0000269|PubMed 381306}; pH dependence Optimum pH is 10.0. {ECO 0000269|PubMed 381306}; # BioGrid 4262604 220 # CATALYTIC ACTIVITY WECC_ECOLI UDP-N-acetyl-alpha-D-mannosamine + 2 NAD(+) + H(2)O = UDP-N-acetyl-alpha-D-mannosaminuronate + 2 NADH. {ECO 0000255|HAMAP-Rule MF_02029, ECO 0000269|PubMed 381306}. # DISRUPTION PHENOTYPE Mutants do not synthesize Und-PP-GlcNAc- ManNAcA (lipid II) and enterobacterial common antigen (ECA). {ECO:0000269|PubMed 2166030}. # ENZYME REGULATION Activated by N-acetylglucosamine-1-P or K(+) at low UDP-ManNAc concentrations. {ECO:0000269|PubMed 381306}. # EcoGene EG11452 wecC # FUNCTION WECC_ECOLI Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA). {ECO 0000255|HAMAP- Rule MF_02029, ECO 0000269|PubMed 381306}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003979 UDP-glucose 6-dehydrogenase activity; IBA:GO_Central. # GO_function GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; IEA:InterPro. # GO_function GO:0051287 NAD binding; IEA:InterPro. # GO_function GO:0089714 UDP-N-acetyl-D-mannosamine dehydrogenase activity; IDA:EcoCyc. # GO_process GO:0006065 UDP-glucuronate biosynthetic process; IBA:GO_Central. # GO_process GO:0009246 enterobacterial common antigen biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.720 -; 2. # HAMAP MF_02029 WecC_RffD # InterPro IPR001732 UDP-Glc/GDP-Man_DH_N # InterPro IPR008927 6-PGluconate_DH_C-like # InterPro IPR014026 UDP-Glc/GDP-Man_DH_dimer # InterPro IPR014027 UDP-Glc/GDP-Man_DH_C # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR017476 UDP-Glc/GDP-Man # InterPro IPR028359 UDP_ManNAc/GlcNAc_DH # InterPro IPR032891 WecC # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00520 Amino sugar and nucleotide sugar metabolism # Organism WECC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11374 PTHR11374 # PATHWAY WECC_ECOLI Bacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis. {ECO 0000255|HAMAP-Rule MF_02029, ECO 0000269|PubMed 2166030}. # PATRIC 32123067 VBIEscCol129921_3903 # PIR F65182 F65182 # PIRSF PIRSF000124 UDPglc_GDPman_dh # PIRSF PIRSF500136 UDP_ManNAc_DH # Pfam PF00984 UDPG_MGDP_dh # Pfam PF03720 UDPG_MGDP_dh_C # Pfam PF03721 UDPG_MGDP_dh_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName WECC_ECOLI UDP-N-acetyl-D-mannosamine dehydrogenase {ECO 0000255|HAMAP-Rule MF_02029, ECO 0000303|PubMed 381306} # RefSeq WP_000006621 NZ_LN832404.1 # RefSeq YP_026254 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA67587.1; Type=Frameshift; Positions=375; Evidence={ECO 0000305}; # SIMILARITY Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. WecC subfamily. {ECO:0000255|HAMAP-Rule MF_02029, ECO:0000305}. # SMART SM00984 UDPG_MGDP_dh_C # SUBUNIT Homodimer. {ECO:0000269|PubMed 381306}. # SUPFAM SSF48179 SSF48179 # SUPFAM SSF51735 SSF51735 # SUPFAM SSF52413 SSF52413 # TIGRFAMs TIGR03026 NDP-sugDHase # eggNOG COG0677 LUCA # eggNOG ENOG4107QQG Bacteria BLAST swissprot:WECC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:WECC_ECOLI BioCyc ECOL316407:JW5599-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5599-MONOMER BioCyc EcoCyc:UDPMANNACADEHYDROG-MONOMER http://biocyc.org/getid?id=EcoCyc:UDPMANNACADEHYDROG-MONOMER BioCyc MetaCyc:UDPMANNACADEHYDROG-MONOMER http://biocyc.org/getid?id=MetaCyc:UDPMANNACADEHYDROG-MONOMER COG COG0677 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0677 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.336 {ECO:0000255|HAMAP-Rule:MF_02029, ECO:0000269|PubMed:381306} http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.336 {ECO:0000255|HAMAP-Rule:MF_02029, ECO:0000269|PubMed:381306} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L18799 http://www.ebi.ac.uk/ena/data/view/L18799 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.1.1.336 {ECO:0000255|HAMAP-Rule:MF_02029, ECO:0000269|PubMed:381306} http://enzyme.expasy.org/EC/1.1.1.336 {ECO:0000255|HAMAP-Rule:MF_02029, ECO:0000269|PubMed:381306} EchoBASE EB1421 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1421 EcoGene EG11452 http://www.ecogene.org/geneInfo.php?eg_id=EG11452 EnsemblBacteria AAT48212 http://www.ensemblgenomes.org/id/AAT48212 EnsemblBacteria AAT48212 http://www.ensemblgenomes.org/id/AAT48212 EnsemblBacteria BAE77511 http://www.ensemblgenomes.org/id/BAE77511 EnsemblBacteria BAE77511 http://www.ensemblgenomes.org/id/BAE77511 EnsemblBacteria BAE77511 http://www.ensemblgenomes.org/id/BAE77511 EnsemblBacteria b3787 http://www.ensemblgenomes.org/id/b3787 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003979 GO_function GO:0016628 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016628 GO_function GO:0051287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051287 GO_function GO:0089714 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0089714 GO_process GO:0006065 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006065 GO_process GO:0009246 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009246 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 948977 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948977 HAMAP MF_02029 http://hamap.expasy.org/unirule/MF_02029 HOGENOM HOG000153774 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000153774&db=HOGENOM6 InParanoid P27829 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P27829 IntEnz 1.1.1.336 {ECO:0000255|HAMAP-Rule:MF_02029, ECO:0000269|PubMed:381306} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.336 {ECO:0000255|HAMAP-Rule:MF_02029, ECO:0000269|PubMed:381306} InterPro IPR001732 http://www.ebi.ac.uk/interpro/entry/IPR001732 InterPro IPR008927 http://www.ebi.ac.uk/interpro/entry/IPR008927 InterPro IPR014026 http://www.ebi.ac.uk/interpro/entry/IPR014026 InterPro IPR014027 http://www.ebi.ac.uk/interpro/entry/IPR014027 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR017476 http://www.ebi.ac.uk/interpro/entry/IPR017476 InterPro IPR028359 http://www.ebi.ac.uk/interpro/entry/IPR028359 InterPro IPR032891 http://www.ebi.ac.uk/interpro/entry/IPR032891 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5599 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5599 KEGG_Gene eco:b3787 http://www.genome.jp/dbget-bin/www_bget?eco:b3787 KEGG_Orthology KO:K02472 http://www.genome.jp/dbget-bin/www_bget?KO:K02472 KEGG_Pathway ko00520 http://www.genome.jp/kegg-bin/show_pathway?ko00520 KEGG_Reaction rn:R03317 http://www.genome.jp/dbget-bin/www_bget?rn:R03317 OMA IQQKRVD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IQQKRVD PANTHER PTHR11374 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11374 PSORT swissprot:WECC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:WECC_ECOLI PSORT-B swissprot:WECC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:WECC_ECOLI PSORT2 swissprot:WECC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:WECC_ECOLI Pfam PF00984 http://pfam.xfam.org/family/PF00984 Pfam PF03720 http://pfam.xfam.org/family/PF03720 Pfam PF03721 http://pfam.xfam.org/family/PF03721 Phobius swissprot:WECC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:WECC_ECOLI PhylomeDB P27829 http://phylomedb.org/?seqid=P27829 ProteinModelPortal P27829 http://www.proteinmodelportal.org/query/uniprot/P27829 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2166030 http://www.ncbi.nlm.nih.gov/pubmed/2166030 PubMed 381306 http://www.ncbi.nlm.nih.gov/pubmed/381306 PubMed 8226648 http://www.ncbi.nlm.nih.gov/pubmed/8226648 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000006621 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000006621 RefSeq YP_026254 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026254 SMART SM00984 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00984 SMR P27829 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P27829 STRING 511145.b3787 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3787&targetmode=cogs STRING COG0677 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0677&targetmode=cogs SUPFAM SSF48179 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48179 SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 SUPFAM SSF52413 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52413 TIGRFAMs TIGR03026 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03026 UniProtKB WECC_ECOLI http://www.uniprot.org/uniprot/WECC_ECOLI UniProtKB-AC P27829 http://www.uniprot.org/uniprot/P27829 charge swissprot:WECC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:WECC_ECOLI eggNOG COG0677 http://eggnogapi.embl.de/nog_data/html/tree/COG0677 eggNOG ENOG4107QQG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QQG epestfind swissprot:WECC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:WECC_ECOLI garnier swissprot:WECC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:WECC_ECOLI helixturnhelix swissprot:WECC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:WECC_ECOLI hmoment swissprot:WECC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:WECC_ECOLI iep swissprot:WECC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:WECC_ECOLI inforesidue swissprot:WECC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:WECC_ECOLI octanol swissprot:WECC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:WECC_ECOLI pepcoil swissprot:WECC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:WECC_ECOLI pepdigest swissprot:WECC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:WECC_ECOLI pepinfo swissprot:WECC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:WECC_ECOLI pepnet swissprot:WECC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:WECC_ECOLI pepstats swissprot:WECC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:WECC_ECOLI pepwheel swissprot:WECC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:WECC_ECOLI pepwindow swissprot:WECC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:WECC_ECOLI sigcleave swissprot:WECC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:WECC_ECOLI ## Database ID URL or Descriptions # BioGrid 4262543 15 # EcoGene EG12276 xylH # FUNCTION XYLH_ECOLI Part of the binding-protein-dependent transport system for D-xylose. Probably responsible for the translocation of the substrate across the membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IBA:GO_Central. # GO_function GO:0005215 transporter activity; IEA:InterPro. # GO_process GO:0008643 carbohydrate transport; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006810 transport # IntAct P0AGI4 3 # InterPro IPR001851 ABC_transp_permease # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00215 D-Xylose transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism XYLH_ECOLI Escherichia coli (strain K12) # PATRIC 32122612 VBIEscCol129921_3683 # PIR S47789 S47789 # Pfam PF02653 BPD_transp_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName XYLH_ECOLI Xylose transport system permease protein XylH # RefSeq NP_418025 NC_000913.3 # RefSeq WP_000045978 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION XYLH_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 3.A.1.2 the atp-binding cassette (abc) superfamily # eggNOG COG4214 LUCA # eggNOG ENOG4108HWW Bacteria BLAST swissprot:XYLH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:XYLH_ECOLI BioCyc ECOL316407:JW3540-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3540-MONOMER BioCyc EcoCyc:XYLH-MONOMER http://biocyc.org/getid?id=EcoCyc:XYLH-MONOMER BioCyc MetaCyc:XYLH-MONOMER http://biocyc.org/getid?id=MetaCyc:XYLH-MONOMER COG COG4214 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4214 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2185 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2185 EcoGene EG12276 http://www.ecogene.org/geneInfo.php?eg_id=EG12276 EnsemblBacteria AAC76592 http://www.ensemblgenomes.org/id/AAC76592 EnsemblBacteria AAC76592 http://www.ensemblgenomes.org/id/AAC76592 EnsemblBacteria BAE77725 http://www.ensemblgenomes.org/id/BAE77725 EnsemblBacteria BAE77725 http://www.ensemblgenomes.org/id/BAE77725 EnsemblBacteria BAE77725 http://www.ensemblgenomes.org/id/BAE77725 EnsemblBacteria b3568 http://www.ensemblgenomes.org/id/b3568 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_process GO:0008643 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008643 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948083 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948083 HOGENOM HOG000212233 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000212233&db=HOGENOM6 InParanoid P0AGI4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGI4 IntAct P0AGI4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AGI4* InterPro IPR001851 http://www.ebi.ac.uk/interpro/entry/IPR001851 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3540 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3540 KEGG_Gene eco:b3568 http://www.genome.jp/dbget-bin/www_bget?eco:b3568 KEGG_Orthology KO:K10544 http://www.genome.jp/dbget-bin/www_bget?KO:K10544 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA LREYGML http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LREYGML PSORT swissprot:XYLH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:XYLH_ECOLI PSORT-B swissprot:XYLH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:XYLH_ECOLI PSORT2 swissprot:XYLH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:XYLH_ECOLI Pfam PF02653 http://pfam.xfam.org/family/PF02653 Phobius swissprot:XYLH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:XYLH_ECOLI PhylomeDB P0AGI4 http://phylomedb.org/?seqid=P0AGI4 ProteinModelPortal P0AGI4 http://www.proteinmodelportal.org/query/uniprot/P0AGI4 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418025 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418025 RefSeq WP_000045978 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000045978 STRING 511145.b3568 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3568&targetmode=cogs STRING COG4214 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4214&targetmode=cogs TCDB 3.A.1.2 http://www.tcdb.org/search/result.php?tc=3.A.1.2 UniProtKB XYLH_ECOLI http://www.uniprot.org/uniprot/XYLH_ECOLI UniProtKB-AC P0AGI4 http://www.uniprot.org/uniprot/P0AGI4 charge swissprot:XYLH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:XYLH_ECOLI eggNOG COG4214 http://eggnogapi.embl.de/nog_data/html/tree/COG4214 eggNOG ENOG4108HWW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108HWW epestfind swissprot:XYLH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:XYLH_ECOLI garnier swissprot:XYLH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:XYLH_ECOLI helixturnhelix swissprot:XYLH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:XYLH_ECOLI hmoment swissprot:XYLH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:XYLH_ECOLI iep swissprot:XYLH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:XYLH_ECOLI inforesidue swissprot:XYLH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:XYLH_ECOLI octanol swissprot:XYLH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:XYLH_ECOLI pepcoil swissprot:XYLH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:XYLH_ECOLI pepdigest swissprot:XYLH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:XYLH_ECOLI pepinfo swissprot:XYLH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:XYLH_ECOLI pepnet swissprot:XYLH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:XYLH_ECOLI pepstats swissprot:XYLH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:XYLH_ECOLI pepwheel swissprot:XYLH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:XYLH_ECOLI pepwindow swissprot:XYLH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:XYLH_ECOLI sigcleave swissprot:XYLH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:XYLH_ECOLI ## Database ID URL or Descriptions # BioGrid 4263255 7 # CDD cd06261 TM_PBP2 # EcoGene EG12077 nikC # FUNCTION NIKC_ECOLI Involved in a nickel transport system, probably translocates nickel through the bacterial inner membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0015099 nickel cation transmembrane transporter activity; IMP:EcoCyc. # GO_function GO:0016151 nickel cation binding; IDA:EcoCyc. # GO_process GO:0035444 nickel cation transmembrane transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0055085 transmembrane transport # Gene3D 1.10.3720.10 -; 1. # InterPro IPR000515 MetI-like # InterPro IPR014157 Nickel_NikC # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00440 Nickel transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism NIKC_ECOLI Escherichia coli (strain K12) # PATRIC 32122400 VBIEscCol129921_3577 # PIR S39596 S39596 # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NIKC_ECOLI Nickel transport system permease protein NikC # RefSeq NP_417935 NC_000913.3 # RefSeq WP_001008963 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION NIKC_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT NIKC_ECOLI Probably forms a heterodimeric pore with NikB. # SUPFAM SSF161098 SSF161098 # TCDB 3.A.1.5 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR02790 nickel_nikC # eggNOG COG1173 LUCA # eggNOG ENOG4105C2T Bacteria BLAST swissprot:NIKC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NIKC_ECOLI BioCyc ECOL316407:JW3443-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3443-MONOMER BioCyc EcoCyc:NIKC-MONOMER http://biocyc.org/getid?id=EcoCyc:NIKC-MONOMER BioCyc MetaCyc:NIKC-MONOMER http://biocyc.org/getid?id=MetaCyc:NIKC-MONOMER COG COG1173 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1173 DIP DIP-48065N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48065N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1111/j.1365-2958.1993.tb01247.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb01247.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X73143 http://www.ebi.ac.uk/ena/data/view/X73143 EchoBASE EB2002 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2002 EcoGene EG12077 http://www.ecogene.org/geneInfo.php?eg_id=EG12077 EnsemblBacteria AAC76503 http://www.ensemblgenomes.org/id/AAC76503 EnsemblBacteria AAC76503 http://www.ensemblgenomes.org/id/AAC76503 EnsemblBacteria BAE77815 http://www.ensemblgenomes.org/id/BAE77815 EnsemblBacteria BAE77815 http://www.ensemblgenomes.org/id/BAE77815 EnsemblBacteria BAE77815 http://www.ensemblgenomes.org/id/BAE77815 EnsemblBacteria b3478 http://www.ensemblgenomes.org/id/b3478 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015099 GO_function GO:0016151 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016151 GO_process GO:0035444 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035444 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 947990 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947990 HOGENOM HOG000171368 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000171368&db=HOGENOM6 InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 InterPro IPR014157 http://www.ebi.ac.uk/interpro/entry/IPR014157 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3443 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3443 KEGG_Gene eco:b3478 http://www.genome.jp/dbget-bin/www_bget?eco:b3478 KEGG_Orthology KO:K15586 http://www.genome.jp/dbget-bin/www_bget?KO:K15586 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA SEWVMAS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SEWVMAS PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:NIKC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NIKC_ECOLI PSORT-B swissprot:NIKC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NIKC_ECOLI PSORT2 swissprot:NIKC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NIKC_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Phobius swissprot:NIKC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NIKC_ECOLI PhylomeDB P0AFA9 http://phylomedb.org/?seqid=P0AFA9 ProteinModelPortal P0AFA9 http://www.proteinmodelportal.org/query/uniprot/P0AFA9 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7934931 http://www.ncbi.nlm.nih.gov/pubmed/7934931 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417935 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417935 RefSeq WP_001008963 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001008963 STRING 511145.b3478 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3478&targetmode=cogs STRING COG1173 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1173&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.5 http://www.tcdb.org/search/result.php?tc=3.A.1.5 TIGRFAMs TIGR02790 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02790 UniProtKB NIKC_ECOLI http://www.uniprot.org/uniprot/NIKC_ECOLI UniProtKB-AC P0AFA9 http://www.uniprot.org/uniprot/P0AFA9 charge swissprot:NIKC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NIKC_ECOLI eggNOG COG1173 http://eggnogapi.embl.de/nog_data/html/tree/COG1173 eggNOG ENOG4105C2T http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C2T epestfind swissprot:NIKC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NIKC_ECOLI garnier swissprot:NIKC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NIKC_ECOLI helixturnhelix swissprot:NIKC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NIKC_ECOLI hmoment swissprot:NIKC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NIKC_ECOLI iep swissprot:NIKC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NIKC_ECOLI inforesidue swissprot:NIKC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NIKC_ECOLI octanol swissprot:NIKC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NIKC_ECOLI pepcoil swissprot:NIKC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NIKC_ECOLI pepdigest swissprot:NIKC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NIKC_ECOLI pepinfo swissprot:NIKC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NIKC_ECOLI pepnet swissprot:NIKC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NIKC_ECOLI pepstats swissprot:NIKC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NIKC_ECOLI pepwheel swissprot:NIKC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NIKC_ECOLI pepwindow swissprot:NIKC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NIKC_ECOLI sigcleave swissprot:NIKC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NIKC_ECOLI ## Database ID URL or Descriptions # BioGrid 4261688 119 # EcoGene EG11117 yceB # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GOslim_component GO:0005886 plasma membrane # InterPro IPR010835 DUF1439 # Organism YCEB_ECOLI Escherichia coli (strain K12) # PATRIC 32117365 VBIEscCol129921_1105 # PDB 3L6I X-ray; 2.01 A; A/B=20-186 # PIR B25008 QQECP5 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF07273 DUF1439 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCEB_ECOLI Uncharacterized lipoprotein YceB # RefSeq NP_415581 NC_000913.3 # RefSeq WP_001295443 NZ_LN832404.1 # SUBCELLULAR LOCATION YCEB_ECOLI Cell membrane {ECO 0000255|PROSITE- ProRule PRU00303}; Lipid-anchor {ECO 0000255|PROSITE- ProRule PRU00303}. # eggNOG ENOG4105F3T Bacteria # eggNOG ENOG410XXD0 LUCA BLAST swissprot:YCEB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCEB_ECOLI BioCyc ECOL316407:JW1050-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1050-MONOMER BioCyc EcoCyc:EG11117-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11117-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1432-1033.1986.tb09942.x http://dx.doi.org/10.1111/j.1432-1033.1986.tb09942.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X04469 http://www.ebi.ac.uk/ena/data/view/X04469 EchoBASE EB1107 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1107 EcoGene EG11117 http://www.ecogene.org/geneInfo.php?eg_id=EG11117 EnsemblBacteria AAC74147 http://www.ensemblgenomes.org/id/AAC74147 EnsemblBacteria AAC74147 http://www.ensemblgenomes.org/id/AAC74147 EnsemblBacteria BAA35871 http://www.ensemblgenomes.org/id/BAA35871 EnsemblBacteria BAA35871 http://www.ensemblgenomes.org/id/BAA35871 EnsemblBacteria BAA35871 http://www.ensemblgenomes.org/id/BAA35871 EnsemblBacteria b1063 http://www.ensemblgenomes.org/id/b1063 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 947377 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947377 HOGENOM HOG000278581 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278581&db=HOGENOM6 IntAct P0AB26 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AB26* InterPro IPR010835 http://www.ebi.ac.uk/interpro/entry/IPR010835 KEGG_Gene ecj:JW1050 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1050 KEGG_Gene eco:b1063 http://www.genome.jp/dbget-bin/www_bget?eco:b1063 OMA ELVIPFT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ELVIPFT PDB 3L6I http://www.ebi.ac.uk/pdbe-srv/view/entry/3L6I PDBsum 3L6I http://www.ebi.ac.uk/pdbsum/3L6I PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YCEB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCEB_ECOLI PSORT-B swissprot:YCEB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCEB_ECOLI PSORT2 swissprot:YCEB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCEB_ECOLI Pfam PF07273 http://pfam.xfam.org/family/PF07273 Phobius swissprot:YCEB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCEB_ECOLI ProteinModelPortal P0AB26 http://www.proteinmodelportal.org/query/uniprot/P0AB26 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2876892 http://www.ncbi.nlm.nih.gov/pubmed/2876892 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415581 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415581 RefSeq WP_001295443 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295443 SMR P0AB26 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AB26 STRING 511145.b1063 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1063&targetmode=cogs SWISS-2DPAGE P0AB26 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AB26 UniProtKB YCEB_ECOLI http://www.uniprot.org/uniprot/YCEB_ECOLI UniProtKB-AC P0AB26 http://www.uniprot.org/uniprot/P0AB26 charge swissprot:YCEB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCEB_ECOLI eggNOG ENOG4105F3T http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F3T eggNOG ENOG410XXD0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XXD0 epestfind swissprot:YCEB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCEB_ECOLI garnier swissprot:YCEB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCEB_ECOLI helixturnhelix swissprot:YCEB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCEB_ECOLI hmoment swissprot:YCEB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCEB_ECOLI iep swissprot:YCEB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCEB_ECOLI inforesidue swissprot:YCEB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCEB_ECOLI octanol swissprot:YCEB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCEB_ECOLI pepcoil swissprot:YCEB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCEB_ECOLI pepdigest swissprot:YCEB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCEB_ECOLI pepinfo swissprot:YCEB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCEB_ECOLI pepnet swissprot:YCEB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCEB_ECOLI pepstats swissprot:YCEB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCEB_ECOLI pepwheel swissprot:YCEB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCEB_ECOLI pepwindow swissprot:YCEB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCEB_ECOLI sigcleave swissprot:YCEB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCEB_ECOLI ## Database ID URL or Descriptions # AltName ULAG_ECOLI L-ascorbate utilization protein G # BRENDA 3.1.4 2026 # BioGrid 4262712 5 # CATALYTIC ACTIVITY ULAG_ECOLI L-ascorbate 6-phosphate + H(2)O = 3-dehydro-L- gulonate 6-phosphate. # COFACTOR Name=a divalent metal cation; Xref=ChEBI:CHEBI 60240; Evidence={ECO:0000305}; # EcoGene EG12492 ulaG # FUNCTION ULAG_ECOLI Probably catalyzes the hydrolysis of L-ascorbate-6-P into 3-keto-L-gulonate-6-P. Is essential for L-ascorbate utilization under anaerobic conditions. Also shows phosphodiesterase activity, hydrolyzing phosphodiester bond in the artificial chromogenic substrate bis-p-nitrophenyl phosphate (bis- pNPP). {ECO 0000269|PubMed 12644495, ECO 0000269|PubMed 15808744}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0030145 manganese ion binding; IDA:EcoCyc. # GO_function GO:0035460 L-ascorbate 6-phosphate lactonase activity; IDA:EcoCyc. # GO_process GO:0019854 L-ascorbic acid catabolic process; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.60.15.10 -; 1. # HAMAP MF_01266 UlaG # INDUCTION ULAG_ECOLI Induced by L-ascorbate. Repressed by UlaR. {ECO 0000269|PubMed 12374842, ECO 0000269|PubMed 14996803}. # InterPro IPR001279 Metallo-B-lactamas # InterPro IPR023951 L-ascorbate_6P_UlaG # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00053 Ascorbate and aldarate metabolism # Organism ULAG_ECOLI Escherichia coli (strain K12) # PATHWAY Cofactor degradation; L-ascorbate degradation; D-xylulose 5-phosphate from L-ascorbate step 1/4. # PATRIC 32123959 VBIEscCol129921_4324 # PDB 2WYL X-ray; 2.59 A; A/B/C/D/E/F=1-354 # PDB 2WYM X-ray; 2.60 A; A/B/C/D/E/F=1-354 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ULAG_ECOLI Probable L-ascorbate-6-phosphate lactonase UlaG # RefSeq NP_418613 NC_000913.3 # RefSeq WP_001295191 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97088.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the UlaG family. {ECO 0000305}. # SUBCELLULAR LOCATION ULAG_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF56281 SSF56281 # UniPathway UPA00263 UER00377 # eggNOG COG2220 LUCA # eggNOG ENOG4105CP1 Bacteria BLAST swissprot:ULAG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ULAG_ECOLI BioCyc ECOL316407:JW5868-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5868-MONOMER BioCyc EcoCyc:G7855-MONOMER http://biocyc.org/getid?id=EcoCyc:G7855-MONOMER BioCyc MetaCyc:G7855-MONOMER http://biocyc.org/getid?id=MetaCyc:G7855-MONOMER COG COG2220 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2220 DIP DIP-12596N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12596N DOI 10.1016/j.fmrre.2004.12.006 http://dx.doi.org/10.1016/j.fmrre.2004.12.006 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.21.6065-6068.2002 http://dx.doi.org/10.1128/JB.184.21.6065-6068.2002 DOI 10.1128/JB.185.7.2243-2250.2003 http://dx.doi.org/10.1128/JB.185.7.2243-2250.2003 DOI 10.1128/JB.186.6.1720-1728.2004 http://dx.doi.org/10.1128/JB.186.6.1720-1728.2004 EC_number EC:3.1.1.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 3.1.1.- http://enzyme.expasy.org/EC/3.1.1.- EchoBASE EB2385 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2385 EcoGene EG12492 http://www.ecogene.org/geneInfo.php?eg_id=EG12492 EnsemblBacteria AAC77149 http://www.ensemblgenomes.org/id/AAC77149 EnsemblBacteria AAC77149 http://www.ensemblgenomes.org/id/AAC77149 EnsemblBacteria BAE78193 http://www.ensemblgenomes.org/id/BAE78193 EnsemblBacteria BAE78193 http://www.ensemblgenomes.org/id/BAE78193 EnsemblBacteria BAE78193 http://www.ensemblgenomes.org/id/BAE78193 EnsemblBacteria b4192 http://www.ensemblgenomes.org/id/b4192 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_function GO:0035460 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035460 GO_process GO:0019854 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019854 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.60.15.10 http://www.cathdb.info/version/latest/superfamily/3.60.15.10 GeneID 948705 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948705 HAMAP MF_01266 http://hamap.expasy.org/unirule/MF_01266 HOGENOM HOG000127385 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000127385&db=HOGENOM6 InParanoid P39300 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39300 IntEnz 3.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.1 InterPro IPR001279 http://www.ebi.ac.uk/interpro/entry/IPR001279 InterPro IPR023951 http://www.ebi.ac.uk/interpro/entry/IPR023951 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5868 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5868 KEGG_Gene eco:b4192 http://www.genome.jp/dbget-bin/www_bget?eco:b4192 KEGG_Orthology KO:K03476 http://www.genome.jp/dbget-bin/www_bget?KO:K03476 KEGG_Pathway ko00053 http://www.genome.jp/kegg-bin/show_pathway?ko00053 KEGG_Reaction rn:R07677 http://www.genome.jp/dbget-bin/www_bget?rn:R07677 OMA HGGDTKP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HGGDTKP PDB 2WYL http://www.ebi.ac.uk/pdbe-srv/view/entry/2WYL PDB 2WYM http://www.ebi.ac.uk/pdbe-srv/view/entry/2WYM PDBsum 2WYL http://www.ebi.ac.uk/pdbsum/2WYL PDBsum 2WYM http://www.ebi.ac.uk/pdbsum/2WYM PSORT swissprot:ULAG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ULAG_ECOLI PSORT-B swissprot:ULAG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ULAG_ECOLI PSORT2 swissprot:ULAG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ULAG_ECOLI Phobius swissprot:ULAG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ULAG_ECOLI PhylomeDB P39300 http://phylomedb.org/?seqid=P39300 ProteinModelPortal P39300 http://www.proteinmodelportal.org/query/uniprot/P39300 PubMed 12374842 http://www.ncbi.nlm.nih.gov/pubmed/12374842 PubMed 12644495 http://www.ncbi.nlm.nih.gov/pubmed/12644495 PubMed 14996803 http://www.ncbi.nlm.nih.gov/pubmed/14996803 PubMed 15808744 http://www.ncbi.nlm.nih.gov/pubmed/15808744 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418613 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418613 RefSeq WP_001295191 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295191 SMR P39300 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39300 STRING 511145.b4192 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4192&targetmode=cogs STRING COG2220 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2220&targetmode=cogs SUPFAM SSF56281 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56281 UniProtKB ULAG_ECOLI http://www.uniprot.org/uniprot/ULAG_ECOLI UniProtKB-AC P39300 http://www.uniprot.org/uniprot/P39300 charge swissprot:ULAG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ULAG_ECOLI eggNOG COG2220 http://eggnogapi.embl.de/nog_data/html/tree/COG2220 eggNOG ENOG4105CP1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CP1 epestfind swissprot:ULAG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ULAG_ECOLI garnier swissprot:ULAG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ULAG_ECOLI helixturnhelix swissprot:ULAG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ULAG_ECOLI hmoment swissprot:ULAG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ULAG_ECOLI iep swissprot:ULAG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ULAG_ECOLI inforesidue swissprot:ULAG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ULAG_ECOLI octanol swissprot:ULAG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ULAG_ECOLI pepcoil swissprot:ULAG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ULAG_ECOLI pepdigest swissprot:ULAG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ULAG_ECOLI pepinfo swissprot:ULAG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ULAG_ECOLI pepnet swissprot:ULAG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ULAG_ECOLI pepstats swissprot:ULAG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ULAG_ECOLI pepwheel swissprot:ULAG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ULAG_ECOLI pepwindow swissprot:ULAG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ULAG_ECOLI sigcleave swissprot:ULAG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ULAG_ECOLI ## Database ID URL or Descriptions # BioGrid 4260215 133 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # CDD cd06174 MFS # EcoGene EG13822 ydfJ # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015293 symporter activity; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # InterPro IPR004736 Cit_H_symport # InterPro IPR005828 MFS_sugar_transport-like # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # Organism YDFJ_ECOLI Escherichia coli (strain K12) # PATRIC 48662404 VBIEscCol107702_1563 # PIR B64909 B64909 # PROSITE PS50850 MFS # Pfam PF00083 Sugar_tr # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDFJ_ECOLI Putative inner membrane metabolite transport protein YdfJ # RefSeq WP_000347482 NZ_LN832404.1 # SIMILARITY Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. {ECO 0000305}. # SUBCELLULAR LOCATION YDFJ_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.6 the major facilitator superfamily (mfs) # TIGRFAMs TIGR00883 2A0106 BLAST swissprot:YDFJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDFJ_ECOLI BioCyc ECOL316407:JW1536-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1536-MONOMER BioCyc EcoCyc:B1543-MONOMER http://biocyc.org/getid?id=EcoCyc:B1543-MONOMER DIP DIP-11699N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11699N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3583 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3583 EcoGene EG13822 http://www.ecogene.org/geneInfo.php?eg_id=EG13822 EnsemblBacteria BAA15248 http://www.ensemblgenomes.org/id/BAA15248 EnsemblBacteria BAA15248 http://www.ensemblgenomes.org/id/BAA15248 EnsemblBacteria BAA15248 http://www.ensemblgenomes.org/id/BAA15248 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015293 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 HOGENOM HOG000141613 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000141613&db=HOGENOM6 InParanoid P77228 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77228 IntAct P77228 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77228* InterPro IPR004736 http://www.ebi.ac.uk/interpro/entry/IPR004736 InterPro IPR005828 http://www.ebi.ac.uk/interpro/entry/IPR005828 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Gene ecj:JW1536 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1536 OMA EMFGSRN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EMFGSRN PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:YDFJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDFJ_ECOLI PSORT-B swissprot:YDFJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDFJ_ECOLI PSORT2 swissprot:YDFJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDFJ_ECOLI Pfam PF00083 http://pfam.xfam.org/family/PF00083 Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:YDFJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDFJ_ECOLI PhylomeDB P77228 http://phylomedb.org/?seqid=P77228 ProteinModelPortal P77228 http://www.proteinmodelportal.org/query/uniprot/P77228 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000347482 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000347482 SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.6 http://www.tcdb.org/search/result.php?tc=2.A.1.6 TIGRFAMs TIGR00883 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00883 UniProtKB YDFJ_ECOLI http://www.uniprot.org/uniprot/YDFJ_ECOLI UniProtKB-AC P77228 http://www.uniprot.org/uniprot/P77228 charge swissprot:YDFJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDFJ_ECOLI epestfind swissprot:YDFJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDFJ_ECOLI garnier swissprot:YDFJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDFJ_ECOLI helixturnhelix swissprot:YDFJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDFJ_ECOLI hmoment swissprot:YDFJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDFJ_ECOLI iep swissprot:YDFJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDFJ_ECOLI inforesidue swissprot:YDFJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDFJ_ECOLI octanol swissprot:YDFJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDFJ_ECOLI pepcoil swissprot:YDFJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDFJ_ECOLI pepdigest swissprot:YDFJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDFJ_ECOLI pepinfo swissprot:YDFJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDFJ_ECOLI pepnet swissprot:YDFJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDFJ_ECOLI pepstats swissprot:YDFJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDFJ_ECOLI pepwheel swissprot:YDFJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDFJ_ECOLI pepwindow swissprot:YDFJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDFJ_ECOLI sigcleave swissprot:YDFJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDFJ_ECOLI ## Database ID URL or Descriptions # AltName RELE_ECOLI Endoribonuclease RelE # AltName RELE_ECOLI Toxin RelE # BioGrid 4260243 127 # DISRUPTION PHENOTYPE RELE_ECOLI Cells missing relBE have a higher steady- state level of translation during amino acid starvation than wild- type cells. They survive antibiotic treatment in log phase better than wild-type cells. Cells missing mazE-mazF survive hydroxyurea treatment better than wild-type; further disruption of relE-relB and tonB yields even better survival (PubMed 20005847). {ECO 0000269|PubMed 11717402, ECO 0000269|PubMed 19707553, ECO 0000269|PubMed 20005847}. # EcoGene EG11131 relE # FUNCTION RELE_ECOLI Cross-talk can occur between different TA modules. Ectopic expression of this toxin induces transcription of 7 tested TA modules (dinJ/yafQ, hicAB, mazEF, mqsRA, prlF(sohA)/yhaV, relBEF and yefM/yoeB) with specific cleavage of the relBEF mRNA produced immediately upstream and within the relB coding sequence. The cleaved mRNA can be translated into RelE, leading to a positive feedback cycle of RelE expression. The relBEF operon is required for transcription of the mazEF TA module operon during amino acid starvation. {ECO 0000269|PubMed 23432955}. # FUNCTION RELE_ECOLI Seems to be a principal mediator of cell death in liquid media (PubMed 19707553). Implicated in hydroxy radical-mediated cell death induced by hydroxyurea treatment (PubMed 20005847). {ECO 0000269|PubMed 19707553, ECO 0000269|PubMed 20005847}. # FUNCTION RELE_ECOLI Toxic component of a type II toxin-antitoxin (TA) module (PubMed 9767574). A sequence-specific, ribosome-dependent mRNA endoribonuclease that inhibits translation during amino acid starvation (the stringent response). In vitro acts by cleaving mRNA with high codon specificity in the ribosomal A site between positions 2 and 3. The stop codon UAG is cleaved at a fast rate while UAA and UGA are cleaved with intermediate and slow rates. In vitro mRNA cleavage can also occur in the ribosomal E site after peptide release from peptidyl-tRNA in the P site as well as on free 30S subunits (PubMed 12526800). In vivo cuts frequently in the first 100 codons, most frequently after the second and third base and rarely near the stop codon (PubMed 21324908). Overexpression of RelE results in the inhibition of bacterial growth and a sharp decrease in colony-forming ability which is neutralized by the labile cognate antitoxin RelB. Overexpression also sharply increases persisters (cells that neither grow nor die in the presence of bactericidal agents and are largely responsible for high levels of biofilm tolerance to antimicrobials) (PubMed 15576765). Plays a role in dormancy when expressed in high-density cells in the absence of antitoxin RelB; amino acid starvation and an unidentified extracellular factor promote dormancy, while expression of antitoxin RelB restores cell culturability (PubMed 22210768). Acts with RelB as a corepressor of relBE transcription, considerably increasing the repression of RelB alone. 2 RelB dimers bind to 2 operator sequences; DNA- binding and repression is stronger when complexed with toxin/corepressor RelE by conditional cooperativity (PubMed 9767574, PubMed 19747491, PubMed 18501926, PubMed 22981948). {ECO 0000269|PubMed 11274135, ECO 0000269|PubMed 11717402, ECO 0000269|PubMed 12123459, ECO 0000269|PubMed 12526800, ECO 0000269|PubMed 15576765, ECO 0000269|PubMed 18501926, ECO 0000269|PubMed 18532983, ECO 0000269|PubMed 19747491, ECO 0000269|PubMed 20005802, ECO 0000269|PubMed 21324908, ECO 0000269|PubMed 22210768, ECO 0000269|PubMed 22981948, ECO 0000269|PubMed 24251350, ECO 0000269|PubMed 9767574}. # GO_function GO:0004521 endoribonuclease activity; IDA:EcoCyc. # GO_function GO:0019843 rRNA binding; IEA:UniProtKB-KW. # GO_function GO:0043022 ribosome binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006402 mRNA catabolic process; IDA:EcoCyc. # GO_process GO:0017148 negative regulation of translation; IDA:EcoCyc. # GO_process GO:0034198 cellular response to amino acid starvation; IEP:EcoCyc. # GO_process GO:0046677 response to antibiotic; IMP:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0004518 nuclease activity # GOslim_function GO:0019843 rRNA binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # INDUCTION RELE_ECOLI By amino acid starvation, by glucose starvation and by chloramphenicol; induction is independent of ppGpp. Autorepressed by RelB, RelE acts as a corepressor (PubMed 9767574, PubMed 19747491, PubMed 18501926, PubMed 22981948). Member of the relBEF operon (PubMed 2990907). Operon induced by ectopic expression of toxins HicA, HipA, MazF, MqsR and itself, but not by YafQ (PubMed 23432955). {ECO 0000269|PubMed 11717402, ECO 0000269|PubMed 18501926, ECO 0000269|PubMed 18532983, ECO 0000269|PubMed 19747491, ECO 0000269|PubMed 22981948, ECO 0000269|PubMed 23432955, ECO 0000269|PubMed 2990907, ECO 0000269|PubMed 9767574}. # IntAct P0C077 11 # InterPro IPR007712 RelE/ParE_toxin # MISCELLANEOUS There are estimated to be 550-1100 RelB and 50-100 RelE molecules in rapidly growing cells of MG1655; as they have quite high affinity for each other (dissociation constant of 0.33 nM) there is probably less than 1 free RelE molecule per cell. The RelB(2)-RelE complex has a half-life of over 70 minutes. {ECO:0000269|PubMed 19747491}. # Organism RELE_ECOLI Escherichia coli (strain K12) # PATRIC 32118432 VBIEscCol129921_1636 # PDB 2KC8 NMR; -; A=1-95 # PDB 2KC9 NMR; -; A=1-95 # PDB 4FXE X-ray; 2.75 A; D/E/F=1-95 # PDB 4FXH X-ray; 2.40 A; A/B=1-95 # PDB 4FXI X-ray; 1.80 A; A/B/C=1-95 # PDB 4V7J X-ray; 3.30 A; Ay/By=1-95 # PDB 4V7K X-ray; 3.60 A; Ay/By=1-95 # PIR B22830 QQECR1 # Pfam PF05016 ParE_toxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RELE_ECOLI mRNA interferase RelE # RefSeq NP_416081 NC_000913.3 # RefSeq WP_000323025 NZ_LN832404.1 # SIMILARITY Belongs to the RelE toxin family. {ECO 0000305}. # SUBUNIT RELE_ECOLI Forms an RelB(2)-RelE(2) heterotetramer (PubMed 18501926, PubMed 22981948). Also forms an RelB(2)-RelE heterotrimer (PubMed 18532983, PubMed 19747491). The RelB(2)-RelE complex is probably the one that binds DNA and represses transcription, possibly as 2 heterotrimers, 1 bound to each of 2 operators (PubMed 22981948, PubMed 19747491). RelE occupies the A site of the 70S ribosome, making extensive contacts with the 16S rRNA. Its presence blocks access of tRNAs and translation factors. RelB bound to RelE prevents RelE from entering the ribosomal A site and thus inhibits its endonuclease activity (PubMed 19297318). {ECO 0000269|PubMed 11274135, ECO 0000269|PubMed 18501926, ECO 0000269|PubMed 18532983, ECO 0000269|PubMed 19297318, ECO 0000269|PubMed 19747491, ECO 0000269|PubMed 22981948}. # TIGRFAMs TIGR02385 RelE_StbE # eggNOG COG2026 LUCA # eggNOG ENOG4105K4U Bacteria BLAST swissprot:RELE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RELE_ECOLI BioCyc ECOL316407:JW1555-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1555-MONOMER BioCyc EcoCyc:EG11131-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11131-MONOMER BioCyc MetaCyc:EG11131-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11131-MONOMER COG COG2026 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2026 DIP DIP-35978N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35978N DOI 10.1016/S0079-6603(08)00812-X http://dx.doi.org/10.1016/S0079-6603(08)00812-X DOI 10.1016/S0092-8674(02)01248-5 http://dx.doi.org/10.1016/S0092-8674(02)01248-5 DOI 10.1016/j.cell.2009.11.015 http://dx.doi.org/10.1016/j.cell.2009.11.015 DOI 10.1016/j.jmb.2008.04.039 http://dx.doi.org/10.1016/j.jmb.2008.04.039 DOI 10.1016/j.jmb.2009.09.006 http://dx.doi.org/10.1016/j.jmb.2009.09.006 DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1016/j.str.2012.08.017 http://dx.doi.org/10.1016/j.str.2012.08.017 DOI 10.1021/bi401325c http://dx.doi.org/10.1021/bi401325c DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1998.00993.x http://dx.doi.org/10.1046/j.1365-2958.1998.00993.x DOI 10.1046/j.1365-2958.2002.03027.x http://dx.doi.org/10.1046/j.1365-2958.2002.03027.x DOI 10.1073/pnas.251327898 http://dx.doi.org/10.1073/pnas.251327898 DOI 10.1074/jbc.M110.108969 http://dx.doi.org/10.1074/jbc.M110.108969 DOI 10.1074/jbc.M809656200 http://dx.doi.org/10.1074/jbc.M809656200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1111/j.1365-2958.2008.06313.x http://dx.doi.org/10.1111/j.1365-2958.2008.06313.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.06628-11 http://dx.doi.org/10.1128/JB.06628-11 DOI 10.1128/JB.183.8.2700-2703.2001 http://dx.doi.org/10.1128/JB.183.8.2700-2703.2001 DOI 10.1128/JB.186.24.8172-8180.2004 http://dx.doi.org/10.1128/JB.186.24.8172-8180.2004 DOI 10.1186/1471-2180-13-45 http://dx.doi.org/10.1186/1471-2180-13-45 DOI 10.1371/journal.pone.0006785 http://dx.doi.org/10.1371/journal.pone.0006785 EC_number EC:3.1.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X02405 http://www.ebi.ac.uk/ena/data/view/X02405 ENZYME 3.1.-.- http://enzyme.expasy.org/EC/3.1.-.- EchoBASE EB1121 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1121 EcoGene EG11131 http://www.ecogene.org/geneInfo.php?eg_id=EG11131 EnsemblBacteria AAC74636 http://www.ensemblgenomes.org/id/AAC74636 EnsemblBacteria AAC74636 http://www.ensemblgenomes.org/id/AAC74636 EnsemblBacteria BAA15262 http://www.ensemblgenomes.org/id/BAA15262 EnsemblBacteria BAA15262 http://www.ensemblgenomes.org/id/BAA15262 EnsemblBacteria BAA15262 http://www.ensemblgenomes.org/id/BAA15262 EnsemblBacteria b1563 http://www.ensemblgenomes.org/id/b1563 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004521 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004521 GO_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GO_function GO:0043022 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043022 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0006402 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006402 GO_process GO:0017148 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017148 GO_process GO:0034198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034198 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 GeneID 947549 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947549 HOGENOM HOG000219994 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219994&db=HOGENOM6 InParanoid P0C077 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0C077 IntAct P0C077 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0C077* IntEnz 3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1 InterPro IPR007712 http://www.ebi.ac.uk/interpro/entry/IPR007712 KEGG_Gene ecj:JW1555 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1555 KEGG_Gene eco:b1563 http://www.genome.jp/dbget-bin/www_bget?eco:b1563 KEGG_Orthology KO:K06218 http://www.genome.jp/dbget-bin/www_bget?KO:K06218 MINT MINT-1282331 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1282331 OMA PRVEANR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PRVEANR PDB 2KC8 http://www.ebi.ac.uk/pdbe-srv/view/entry/2KC8 PDB 2KC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/2KC9 PDB 4FXE http://www.ebi.ac.uk/pdbe-srv/view/entry/4FXE PDB 4FXH http://www.ebi.ac.uk/pdbe-srv/view/entry/4FXH PDB 4FXI http://www.ebi.ac.uk/pdbe-srv/view/entry/4FXI PDB 4V7J http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7J PDB 4V7K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7K PDBsum 2KC8 http://www.ebi.ac.uk/pdbsum/2KC8 PDBsum 2KC9 http://www.ebi.ac.uk/pdbsum/2KC9 PDBsum 4FXE http://www.ebi.ac.uk/pdbsum/4FXE PDBsum 4FXH http://www.ebi.ac.uk/pdbsum/4FXH PDBsum 4FXI http://www.ebi.ac.uk/pdbsum/4FXI PDBsum 4V7J http://www.ebi.ac.uk/pdbsum/4V7J PDBsum 4V7K http://www.ebi.ac.uk/pdbsum/4V7K PSORT swissprot:RELE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RELE_ECOLI PSORT-B swissprot:RELE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RELE_ECOLI PSORT2 swissprot:RELE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RELE_ECOLI Pfam PF05016 http://pfam.xfam.org/family/PF05016 Phobius swissprot:RELE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RELE_ECOLI ProteinModelPortal P0C077 http://www.proteinmodelportal.org/query/uniprot/P0C077 PubMed 11274135 http://www.ncbi.nlm.nih.gov/pubmed/11274135 PubMed 11717402 http://www.ncbi.nlm.nih.gov/pubmed/11717402 PubMed 12123459 http://www.ncbi.nlm.nih.gov/pubmed/12123459 PubMed 12526800 http://www.ncbi.nlm.nih.gov/pubmed/12526800 PubMed 15576765 http://www.ncbi.nlm.nih.gov/pubmed/15576765 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18501926 http://www.ncbi.nlm.nih.gov/pubmed/18501926 PubMed 18532983 http://www.ncbi.nlm.nih.gov/pubmed/18532983 PubMed 19215780 http://www.ncbi.nlm.nih.gov/pubmed/19215780 PubMed 19297318 http://www.ncbi.nlm.nih.gov/pubmed/19297318 PubMed 19707553 http://www.ncbi.nlm.nih.gov/pubmed/19707553 PubMed 19747491 http://www.ncbi.nlm.nih.gov/pubmed/19747491 PubMed 20005802 http://www.ncbi.nlm.nih.gov/pubmed/20005802 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 21324908 http://www.ncbi.nlm.nih.gov/pubmed/21324908 PubMed 22210768 http://www.ncbi.nlm.nih.gov/pubmed/22210768 PubMed 22981948 http://www.ncbi.nlm.nih.gov/pubmed/22981948 PubMed 23432955 http://www.ncbi.nlm.nih.gov/pubmed/23432955 PubMed 24251350 http://www.ncbi.nlm.nih.gov/pubmed/24251350 PubMed 2990907 http://www.ncbi.nlm.nih.gov/pubmed/2990907 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9767574 http://www.ncbi.nlm.nih.gov/pubmed/9767574 RefSeq NP_416081 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416081 RefSeq WP_000323025 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000323025 SMR P0C077 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0C077 STRING 511145.b1563 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1563&targetmode=cogs STRING COG2026 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2026&targetmode=cogs TIGRFAMs TIGR02385 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02385 UniProtKB RELE_ECOLI http://www.uniprot.org/uniprot/RELE_ECOLI UniProtKB-AC P0C077 http://www.uniprot.org/uniprot/P0C077 charge swissprot:RELE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RELE_ECOLI eggNOG COG2026 http://eggnogapi.embl.de/nog_data/html/tree/COG2026 eggNOG ENOG4105K4U http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K4U epestfind swissprot:RELE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RELE_ECOLI garnier swissprot:RELE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RELE_ECOLI helixturnhelix swissprot:RELE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RELE_ECOLI hmoment swissprot:RELE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RELE_ECOLI iep swissprot:RELE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RELE_ECOLI inforesidue swissprot:RELE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RELE_ECOLI octanol swissprot:RELE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RELE_ECOLI pepcoil swissprot:RELE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RELE_ECOLI pepdigest swissprot:RELE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RELE_ECOLI pepinfo swissprot:RELE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RELE_ECOLI pepnet swissprot:RELE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RELE_ECOLI pepstats swissprot:RELE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RELE_ECOLI pepwheel swissprot:RELE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RELE_ECOLI pepwindow swissprot:RELE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RELE_ECOLI sigcleave swissprot:RELE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RELE_ECOLI ## Database ID URL or Descriptions # AltName GATY_ECOLI D-tagatose-bisphosphate aldolase class II # AltName GATY_ECOLI Tagatose-bisphosphate aldolase # BIOPHYSICOCHEMICAL PROPERTIES GATY_ECOLI Kinetic parameters KM=1.0 mM for tagatose-1,6-bisphosphate (when expressed alone) {ECO 0000269|PubMed 11976750}; KM=0.3 mM for tagatose-1,6-bisphosphate (when expressed with GatZ) {ECO 0000269|PubMed 11976750}; # BioGrid 4260432 7 # CATALYTIC ACTIVITY GATY_ECOLI D-tagatose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. # CDD cd00947 TBP_aldolase_IIB # COFACTOR GATY_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000250}; Note=Binds 1 zinc ion per subunit. {ECO 0000250}; # EcoGene EG12419 gatY # FUNCTION GATY_ECOLI Catalytic subunit of the tagatose-1,6-bisphosphate aldolase GatYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6- bisphosphate (TBP). Requires GatZ subunit for full activity and stability. Is involved in the catabolism of galactitol. {ECO 0000269|PubMed 11976750, ECO 0000269|PubMed 8955298}. # GO_function GO:0008270 zinc ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0009025 tagatose-bisphosphate aldolase activity; IDA:EcoCyc. # GO_process GO:0019404 galactitol catabolic process; IEA:UniProtKB-HAMAP. # GO_process GO:2001059 D-tagatose 6-phosphate catabolic process; IEA:UniProtKB-UniPathway. # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.70 -; 1. # HAMAP MF_01294 TagBP_aldolase_GatY # INDUCTION GATY_ECOLI Constitutively expressed. Up-regulated under low pH conditions. {ECO 0000269|PubMed 10094700, ECO 0000269|PubMed 8955298}. # IntAct P0C8J6 13 # InterPro IPR000771 FBA_II # InterPro IPR011288 TagBP_ald_KbaY/GatY # InterPro IPR013785 Aldolase_TIM # InterPro IPR023955 TagBP_aldolase_GatY # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00052 Galactose metabolism # Organism GATY_ECOLI Escherichia coli (strain K12) # PATHWAY Carbohydrate metabolism; D-tagatose 6-phosphate degradation; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate step 2/2. # PATRIC 32119525 VBIEscCol129921_2173 # PIR S55901 S55901 # PIRSF PIRSF001359 F_bP_aldolase_II # PROSITE PS00602 ALDOLASE_CLASS_II_1 # PROSITE PS00806 ALDOLASE_CLASS_II_2 # Pfam PF01116 F_bP_aldolase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GATY_ECOLI D-tagatose-1,6-bisphosphate aldolase subunit GatY # RefSeq NP_416599 NC_000913.3 # RefSeq WP_001307281 NZ_LN832404.1 # SIMILARITY Belongs to the class II fructose-bisphosphate aldolase family. TagBP aldolase GatY subfamily. {ECO 0000305}. # SUBUNIT GATY_ECOLI Forms a complex with GatZ. # TIGRFAMs TIGR00167 cbbA # TIGRFAMs TIGR01858 tag_bisphos_ald # UniPathway UPA00704 UER00716 # eggNOG COG0191 LUCA # eggNOG ENOG4105D2N Bacteria BLAST swissprot:GATY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GATY_ECOLI BioCyc EcoCyc:TAGAALDOL2-MONOMER http://biocyc.org/getid?id=EcoCyc:TAGAALDOL2-MONOMER BioCyc MetaCyc:TAGAALDOL2-MONOMER http://biocyc.org/getid?id=MetaCyc:TAGAALDOL2-MONOMER COG COG0191 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0191 DIP DIP-48239N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48239N DOI 10.1007/s00203-002-0406-6 http://dx.doi.org/10.1007/s00203-002-0406-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1266/ggs.82.291 http://dx.doi.org/10.1266/ggs.82.291 EC_number EC:4.1.2.40 http://www.genome.jp/dbget-bin/www_bget?EC:4.1.2.40 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 4.1.2.40 http://enzyme.expasy.org/EC/4.1.2.40 EchoBASE EB2318 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2318 EcoGene EG12419 http://www.ecogene.org/geneInfo.php?eg_id=EG12419 EnsemblBacteria AAC75157 http://www.ensemblgenomes.org/id/AAC75157 EnsemblBacteria AAC75157 http://www.ensemblgenomes.org/id/AAC75157 EnsemblBacteria BAA15966 http://www.ensemblgenomes.org/id/BAA15966 EnsemblBacteria BAA15966 http://www.ensemblgenomes.org/id/BAA15966 EnsemblBacteria BAA15966 http://www.ensemblgenomes.org/id/BAA15966 EnsemblBacteria b2096 http://www.ensemblgenomes.org/id/b2096 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0009025 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009025 GO_process GO:0019404 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019404 GO_process GO:2001059 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2001059 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 946636 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946636 HAMAP MF_01294 http://hamap.expasy.org/unirule/MF_01294 HOGENOM HOG000227793 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000227793&db=HOGENOM6 InParanoid P0C8J6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0C8J6 IntAct P0C8J6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0C8J6* IntEnz 4.1.2.40 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.2.40 InterPro IPR000771 http://www.ebi.ac.uk/interpro/entry/IPR000771 InterPro IPR011288 http://www.ebi.ac.uk/interpro/entry/IPR011288 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR023955 http://www.ebi.ac.uk/interpro/entry/IPR023955 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5343 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5343 KEGG_Gene eco:b2096 http://www.genome.jp/dbget-bin/www_bget?eco:b2096 KEGG_Orthology KO:K08302 http://www.genome.jp/dbget-bin/www_bget?KO:K08302 KEGG_Pathway ko00052 http://www.genome.jp/kegg-bin/show_pathway?ko00052 KEGG_Reaction rn:R01069 http://www.genome.jp/dbget-bin/www_bget?rn:R01069 MINT MINT-1266244 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1266244 OMA LESGMGE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LESGMGE PROSITE PS00602 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00602 PROSITE PS00806 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00806 PSORT swissprot:GATY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GATY_ECOLI PSORT-B swissprot:GATY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GATY_ECOLI PSORT2 swissprot:GATY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GATY_ECOLI Pfam PF01116 http://pfam.xfam.org/family/PF01116 Phobius swissprot:GATY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GATY_ECOLI PhylomeDB P0C8J6 http://phylomedb.org/?seqid=P0C8J6 ProteinModelPortal P0C8J6 http://www.proteinmodelportal.org/query/uniprot/P0C8J6 PubMed 10094700 http://www.ncbi.nlm.nih.gov/pubmed/10094700 PubMed 11976750 http://www.ncbi.nlm.nih.gov/pubmed/11976750 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17895580 http://www.ncbi.nlm.nih.gov/pubmed/17895580 PubMed 8955298 http://www.ncbi.nlm.nih.gov/pubmed/8955298 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416599 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416599 RefSeq WP_001307281 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001307281 SMR P0C8J6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0C8J6 STRING 511145.b2096 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2096&targetmode=cogs STRING COG0191 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0191&targetmode=cogs TIGRFAMs TIGR00167 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00167 TIGRFAMs TIGR01858 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01858 UniProtKB GATY_ECOLI http://www.uniprot.org/uniprot/GATY_ECOLI UniProtKB-AC P0C8J6 http://www.uniprot.org/uniprot/P0C8J6 charge swissprot:GATY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GATY_ECOLI eggNOG COG0191 http://eggnogapi.embl.de/nog_data/html/tree/COG0191 eggNOG ENOG4105D2N http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D2N epestfind swissprot:GATY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GATY_ECOLI garnier swissprot:GATY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GATY_ECOLI helixturnhelix swissprot:GATY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GATY_ECOLI hmoment swissprot:GATY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GATY_ECOLI iep swissprot:GATY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GATY_ECOLI inforesidue swissprot:GATY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GATY_ECOLI octanol swissprot:GATY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GATY_ECOLI pepcoil swissprot:GATY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GATY_ECOLI pepdigest swissprot:GATY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GATY_ECOLI pepinfo swissprot:GATY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GATY_ECOLI pepnet swissprot:GATY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GATY_ECOLI pepstats swissprot:GATY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GATY_ECOLI pepwheel swissprot:GATY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GATY_ECOLI pepwindow swissprot:GATY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GATY_ECOLI sigcleave swissprot:GATY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GATY_ECOLI ## Database ID URL or Descriptions # BioGrid 4262542 7 # CATALYTIC ACTIVITY ATP + H(2)O + monosaccharide(Out) = ADP + phosphate + monosaccharide(In). {ECO:0000255|HAMAP-Rule MF_01722}. # EcoGene EG12275 xylG # FUNCTION XYLG_ECOLI Part of the ABC transporter complex XylFGH involved in xylose import. Responsible for energy coupling to the transport system (Probable). The XylFGH system can also transport ribose in absence of xylose. {ECO 0000255|HAMAP-Rule MF_01722, ECO 0000269|PubMed 9673030, ECO 0000305}. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IEA:UniProtKB-HAMAP. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0015614 D-xylose-importing ATPase activity; IEA:UniProtKB-HAMAP. # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.300 -; 2. # IntAct P37388 7 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR013455 ABC_transptr_xylose_ATP-bd # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00215 D-Xylose transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism XYLG_ECOLI Escherichia coli (strain K12) # PATRIC 32122610 VBIEscCol129921_3682 # PIR S47788 S47788 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2; 2 # PROSITE PS51280 XYLG # Pfam PF00005 ABC_tran; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Xylose import ATP-binding protein XylG {ECO:0000255|HAMAP-Rule MF_01722} # RefSeq NP_418024 NC_000913.3 # RefSeq WP_001146473 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. Xylose importer (TC 3.A.1.2.4) family. {ECO:0000255|HAMAP-Rule MF_01722}. # SIMILARITY Contains 2 ABC transporter domains. {ECO:0000255|HAMAP-Rule MF_01722}. # SMART SM00382 AAA; 2 # SUBCELLULAR LOCATION XYLG_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01722}; Peripheral membrane protein {ECO 0000255|HAMAP- Rule MF_01722}. # SUBUNIT The complex is composed of two ATP-binding proteins (XylG), two transmembrane proteins (XylH) and a solute-binding protein (XylF). {ECO:0000255|HAMAP-Rule MF_01722}. # SUPFAM SSF52540 SSF52540; 2 # TCDB 3.A.1.2 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR02633 xylG # eggNOG COG1129 LUCA # eggNOG ENOG4105C2J Bacteria BLAST swissprot:XYLG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:XYLG_ECOLI BioCyc ECOL316407:JW3539-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3539-MONOMER BioCyc EcoCyc:XYLG-MONOMER http://biocyc.org/getid?id=EcoCyc:XYLG-MONOMER BioCyc MetaCyc:XYLG-MONOMER http://biocyc.org/getid?id=MetaCyc:XYLG-MONOMER COG COG1129 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1129 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1111/j.1574-6968.1998.tb13054.x http://dx.doi.org/10.1111/j.1574-6968.1998.tb13054.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.3.17 {ECO:0000255|HAMAP-Rule:MF_01722} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.17 {ECO:0000255|HAMAP-Rule:MF_01722} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.6.3.17 {ECO:0000255|HAMAP-Rule:MF_01722} http://enzyme.expasy.org/EC/3.6.3.17 {ECO:0000255|HAMAP-Rule:MF_01722} EchoBASE EB2184 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2184 EcoGene EG12275 http://www.ecogene.org/geneInfo.php?eg_id=EG12275 EnsemblBacteria AAC76591 http://www.ensemblgenomes.org/id/AAC76591 EnsemblBacteria AAC76591 http://www.ensemblgenomes.org/id/AAC76591 EnsemblBacteria BAE77726 http://www.ensemblgenomes.org/id/BAE77726 EnsemblBacteria BAE77726 http://www.ensemblgenomes.org/id/BAE77726 EnsemblBacteria BAE77726 http://www.ensemblgenomes.org/id/BAE77726 EnsemblBacteria b3567 http://www.ensemblgenomes.org/id/b3567 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0015614 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015614 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948127 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948127 InParanoid P37388 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37388 IntAct P37388 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37388* IntEnz 3.6.3.17 {ECO:0000255|HAMAP-Rule:MF_01722} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.17 {ECO:0000255|HAMAP-Rule:MF_01722} InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR013455 http://www.ebi.ac.uk/interpro/entry/IPR013455 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3539 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3539 KEGG_Gene eco:b3567 http://www.genome.jp/dbget-bin/www_bget?eco:b3567 KEGG_Orthology KO:K10545 http://www.genome.jp/dbget-bin/www_bget?KO:K10545 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA YPERESH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YPERESH PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PROSITE PS51280 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51280 PSORT swissprot:XYLG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:XYLG_ECOLI PSORT-B swissprot:XYLG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:XYLG_ECOLI PSORT2 swissprot:XYLG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:XYLG_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Phobius swissprot:XYLG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:XYLG_ECOLI PhylomeDB P37388 http://phylomedb.org/?seqid=P37388 ProteinModelPortal P37388 http://www.proteinmodelportal.org/query/uniprot/P37388 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9673030 http://www.ncbi.nlm.nih.gov/pubmed/9673030 RefSeq NP_418024 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418024 RefSeq WP_001146473 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001146473 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 STRING 511145.b3567 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3567&targetmode=cogs STRING COG1129 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1129&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.2 http://www.tcdb.org/search/result.php?tc=3.A.1.2 TIGRFAMs TIGR02633 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02633 UniProtKB XYLG_ECOLI http://www.uniprot.org/uniprot/XYLG_ECOLI UniProtKB-AC P37388 http://www.uniprot.org/uniprot/P37388 charge swissprot:XYLG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:XYLG_ECOLI eggNOG COG1129 http://eggnogapi.embl.de/nog_data/html/tree/COG1129 eggNOG ENOG4105C2J http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C2J epestfind swissprot:XYLG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:XYLG_ECOLI garnier swissprot:XYLG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:XYLG_ECOLI helixturnhelix swissprot:XYLG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:XYLG_ECOLI hmoment swissprot:XYLG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:XYLG_ECOLI iep swissprot:XYLG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:XYLG_ECOLI inforesidue swissprot:XYLG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:XYLG_ECOLI octanol swissprot:XYLG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:XYLG_ECOLI pepcoil swissprot:XYLG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:XYLG_ECOLI pepdigest swissprot:XYLG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:XYLG_ECOLI pepinfo swissprot:XYLG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:XYLG_ECOLI pepnet swissprot:XYLG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:XYLG_ECOLI pepstats swissprot:XYLG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:XYLG_ECOLI pepwheel swissprot:XYLG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:XYLG_ECOLI pepwindow swissprot:XYLG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:XYLG_ECOLI sigcleave swissprot:XYLG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:XYLG_ECOLI ## Database ID URL or Descriptions # BioGrid 4262837 14 # EcoGene EG13233 gnsA # FUNCTION GNSA_ECOLI Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation. {ECO 0000269|PubMed 11544213}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # INTERACTION GNSA_ECOLI Self; NbExp=2; IntAct=EBI-1121356, EBI-1121356; # IntAct P0AC92 9 # InterPro IPR012563 Gns # Organism GNSA_ECOLI Escherichia coli (strain K12) # PATRIC 32117207 VBIEscCol129921_1027 # PDB 4XO1 X-ray; 1.80 A; A=1-57 # PDB 4XO2 X-ray; 1.95 A; A/B=1-57 # Pfam PF08178 GnsAB_toxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GNSA_ECOLI Protein GnsA # RefSeq WP_001019197 NZ_LN832404.1 # RefSeq YP_588446 NC_000913.3 # SIMILARITY Belongs to the gns family. {ECO 0000305}. # eggNOG ENOG4106H71 Bacteria # eggNOG ENOG410Y8R8 LUCA BLAST swissprot:GNSA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GNSA_ECOLI BioCyc ECOL316407:JW0976-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0976-MONOMER BioCyc EcoCyc:MONOMER0-1701 http://biocyc.org/getid?id=EcoCyc:MONOMER0-1701 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.183.19.5523-5528.2001 http://dx.doi.org/10.1128/JB.183.19.5523-5528.2001 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U38541 http://www.ebi.ac.uk/ena/data/view/U38541 EchoBASE EB3022 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3022 EcoGene EG13233 http://www.ecogene.org/geneInfo.php?eg_id=EG13233 EnsemblBacteria ABD18647 http://www.ensemblgenomes.org/id/ABD18647 EnsemblBacteria ABD18647 http://www.ensemblgenomes.org/id/ABD18647 EnsemblBacteria BAA35758 http://www.ensemblgenomes.org/id/BAA35758 EnsemblBacteria BAA35758 http://www.ensemblgenomes.org/id/BAA35758 EnsemblBacteria BAA35758 http://www.ensemblgenomes.org/id/BAA35758 EnsemblBacteria b4517 http://www.ensemblgenomes.org/id/b4517 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GeneID 1450249 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1450249 HOGENOM HOG000268050 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000268050&db=HOGENOM6 IntAct P0AC92 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AC92* InterPro IPR012563 http://www.ebi.ac.uk/interpro/entry/IPR012563 KEGG_Gene ecj:JW0976 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0976 KEGG_Gene eco:b4517 http://www.genome.jp/dbget-bin/www_bget?eco:b4517 PDB 4XO1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4XO1 PDB 4XO2 http://www.ebi.ac.uk/pdbe-srv/view/entry/4XO2 PDBsum 4XO1 http://www.ebi.ac.uk/pdbsum/4XO1 PDBsum 4XO2 http://www.ebi.ac.uk/pdbsum/4XO2 PSORT swissprot:GNSA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GNSA_ECOLI PSORT-B swissprot:GNSA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GNSA_ECOLI PSORT2 swissprot:GNSA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GNSA_ECOLI Pfam PF08178 http://pfam.xfam.org/family/PF08178 Phobius swissprot:GNSA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GNSA_ECOLI ProteinModelPortal P0AC92 http://www.proteinmodelportal.org/query/uniprot/P0AC92 PubMed 11544213 http://www.ncbi.nlm.nih.gov/pubmed/11544213 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8808925 http://www.ncbi.nlm.nih.gov/pubmed/8808925 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001019197 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001019197 RefSeq YP_588446 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_588446 SMR P0AC92 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AC92 STRING 511145.b4517 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4517&targetmode=cogs UniProtKB GNSA_ECOLI http://www.uniprot.org/uniprot/GNSA_ECOLI UniProtKB-AC P0AC92 http://www.uniprot.org/uniprot/P0AC92 charge swissprot:GNSA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GNSA_ECOLI eggNOG ENOG4106H71 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106H71 eggNOG ENOG410Y8R8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y8R8 epestfind swissprot:GNSA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GNSA_ECOLI garnier swissprot:GNSA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GNSA_ECOLI helixturnhelix swissprot:GNSA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GNSA_ECOLI hmoment swissprot:GNSA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GNSA_ECOLI iep swissprot:GNSA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GNSA_ECOLI inforesidue swissprot:GNSA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GNSA_ECOLI octanol swissprot:GNSA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GNSA_ECOLI pepcoil swissprot:GNSA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GNSA_ECOLI pepdigest swissprot:GNSA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GNSA_ECOLI pepinfo swissprot:GNSA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GNSA_ECOLI pepnet swissprot:GNSA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GNSA_ECOLI pepstats swissprot:GNSA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GNSA_ECOLI pepwheel swissprot:GNSA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GNSA_ECOLI pepwindow swissprot:GNSA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GNSA_ECOLI sigcleave swissprot:GNSA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GNSA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261374 133 # EcoGene EG13754 ydcK # GO_function GO:0016746 transferase activity, transferring acyl groups; IEA:UniProtKB-KW. # GOslim_function GO:0016746 transferase activity, transferring acyl groups # IntAct P76100 5 # InterPro IPR011004 Trimer_LpxA-like # Organism YDCK_ECOLI Escherichia coli (strain K12) # PATRIC 32118140 VBIEscCol129921_1490 # PIR G64894 G64894 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDCK_ECOLI Uncharacterized acetyltransferase YdcK # RefSeq NP_415945 NC_000913.3 # RefSeq WP_001234042 NZ_LN832404.1 # SIMILARITY Belongs to the transferase hexapeptide repeat family. {ECO 0000305}. # SUPFAM SSF51161 SSF51161 # eggNOG ENOG4107WE3 Bacteria # eggNOG ENOG410Z3IR LUCA BLAST swissprot:YDCK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDCK_ECOLI BioCyc ECOL316407:JW1424-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1424-MONOMER BioCyc EcoCyc:G6741-MONOMER http://biocyc.org/getid?id=EcoCyc:G6741-MONOMER DIP DIP-11647N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11647N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.3.1.- http://enzyme.expasy.org/EC/2.3.1.- EchoBASE EB3517 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3517 EcoGene EG13754 http://www.ecogene.org/geneInfo.php?eg_id=EG13754 EnsemblBacteria AAC74510 http://www.ensemblgenomes.org/id/AAC74510 EnsemblBacteria AAC74510 http://www.ensemblgenomes.org/id/AAC74510 EnsemblBacteria BAE76435 http://www.ensemblgenomes.org/id/BAE76435 EnsemblBacteria BAE76435 http://www.ensemblgenomes.org/id/BAE76435 EnsemblBacteria BAE76435 http://www.ensemblgenomes.org/id/BAE76435 EnsemblBacteria b1428 http://www.ensemblgenomes.org/id/b1428 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GeneID 944932 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944932 HOGENOM HOG000120564 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120564&db=HOGENOM6 IntAct P76100 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76100* IntEnz 2.3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1 InterPro IPR011004 http://www.ebi.ac.uk/interpro/entry/IPR011004 KEGG_Gene ecj:JW1424 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1424 KEGG_Gene eco:b1428 http://www.genome.jp/dbget-bin/www_bget?eco:b1428 OMA HITRTPL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HITRTPL PSORT swissprot:YDCK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDCK_ECOLI PSORT-B swissprot:YDCK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDCK_ECOLI PSORT2 swissprot:YDCK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDCK_ECOLI Phobius swissprot:YDCK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDCK_ECOLI ProteinModelPortal P76100 http://www.proteinmodelportal.org/query/uniprot/P76100 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415945 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415945 RefSeq WP_001234042 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001234042 STRING 511145.b1428 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1428&targetmode=cogs SUPFAM SSF51161 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51161 UniProtKB YDCK_ECOLI http://www.uniprot.org/uniprot/YDCK_ECOLI UniProtKB-AC P76100 http://www.uniprot.org/uniprot/P76100 charge swissprot:YDCK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDCK_ECOLI eggNOG ENOG4107WE3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107WE3 eggNOG ENOG410Z3IR http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Z3IR epestfind swissprot:YDCK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDCK_ECOLI garnier swissprot:YDCK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDCK_ECOLI helixturnhelix swissprot:YDCK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDCK_ECOLI hmoment swissprot:YDCK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDCK_ECOLI iep swissprot:YDCK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDCK_ECOLI inforesidue swissprot:YDCK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDCK_ECOLI octanol swissprot:YDCK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDCK_ECOLI pepcoil swissprot:YDCK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDCK_ECOLI pepdigest swissprot:YDCK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDCK_ECOLI pepinfo swissprot:YDCK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDCK_ECOLI pepnet swissprot:YDCK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDCK_ECOLI pepstats swissprot:YDCK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDCK_ECOLI pepwheel swissprot:YDCK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDCK_ECOLI pepwindow swissprot:YDCK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDCK_ECOLI sigcleave swissprot:YDCK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDCK_ECOLI ## Database ID URL or Descriptions # BioGrid 4261823 162 # EcoGene EG12992 pppA # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0004175 endopeptidase activity; IMP:EcoCyc. # GO_function GO:0004190 aspartic-type endopeptidase activity; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0008233 peptidase activity # InterPro IPR000045 Prepilin_IV_endopep_pep # InterPro IPR010627 Pept_A24A_N # InterPro IPR014032 Peptidase_A24A_bac # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Brite ko02044 Secretion system # Organism PPPA_ECOLI Escherichia coli (strain K12) # PATRIC 32121360 VBIEscCol129921_3067 # PIR B65083 B65083 # PRINTS PR00864 PREPILNPTASE # Pfam PF01478 Peptidase_A24 # Pfam PF06750 DiS_P_DiS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PPPA_ECOLI Leader peptidase PppA # RefSeq NP_417446 NC_000913.3 # RefSeq WP_001333829 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA69139.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the peptidase A24 family. {ECO 0000305}. # SUBCELLULAR LOCATION PPPA_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG COG1989 LUCA # eggNOG ENOG4105EHH Bacteria BLAST swissprot:PPPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PPPA_ECOLI BioCyc ECOL316407:JW2939-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2939-MONOMER BioCyc EcoCyc:G7539-MONOMER http://biocyc.org/getid?id=EcoCyc:G7539-MONOMER COG COG1989 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1989 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2816 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2816 EcoGene EG12992 http://www.ecogene.org/geneInfo.php?eg_id=EG12992 EnsemblBacteria AAC76008 http://www.ensemblgenomes.org/id/AAC76008 EnsemblBacteria AAC76008 http://www.ensemblgenomes.org/id/AAC76008 EnsemblBacteria BAE77033 http://www.ensemblgenomes.org/id/BAE77033 EnsemblBacteria BAE77033 http://www.ensemblgenomes.org/id/BAE77033 EnsemblBacteria BAE77033 http://www.ensemblgenomes.org/id/BAE77033 EnsemblBacteria b2972 http://www.ensemblgenomes.org/id/b2972 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0004175 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004175 GO_function GO:0004190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004190 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GeneID 947467 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947467 HOGENOM HOG000248584 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000248584&db=HOGENOM6 InParanoid Q46836 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46836 InterPro IPR000045 http://www.ebi.ac.uk/interpro/entry/IPR000045 InterPro IPR010627 http://www.ebi.ac.uk/interpro/entry/IPR010627 InterPro IPR014032 http://www.ebi.ac.uk/interpro/entry/IPR014032 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW2939 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2939 KEGG_Gene eco:b2972 http://www.genome.jp/dbget-bin/www_bget?eco:b2972 KEGG_Orthology KO:K02654 http://www.genome.jp/dbget-bin/www_bget?KO:K02654 OMA RCAYCHE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RCAYCHE PRINTS PR00864 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00864 PSORT swissprot:PPPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PPPA_ECOLI PSORT-B swissprot:PPPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PPPA_ECOLI PSORT2 swissprot:PPPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PPPA_ECOLI Pfam PF01478 http://pfam.xfam.org/family/PF01478 Pfam PF06750 http://pfam.xfam.org/family/PF06750 Phobius swissprot:PPPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PPPA_ECOLI PhylomeDB Q46836 http://phylomedb.org/?seqid=Q46836 ProteinModelPortal Q46836 http://www.proteinmodelportal.org/query/uniprot/Q46836 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417446 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417446 RefSeq WP_001333829 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001333829 SMR Q46836 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46836 STRING 511145.b2972 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2972&targetmode=cogs STRING COG1989 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1989&targetmode=cogs UniProtKB PPPA_ECOLI http://www.uniprot.org/uniprot/PPPA_ECOLI UniProtKB-AC Q46836 http://www.uniprot.org/uniprot/Q46836 charge swissprot:PPPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PPPA_ECOLI eggNOG COG1989 http://eggnogapi.embl.de/nog_data/html/tree/COG1989 eggNOG ENOG4105EHH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EHH epestfind swissprot:PPPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PPPA_ECOLI garnier swissprot:PPPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PPPA_ECOLI helixturnhelix swissprot:PPPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PPPA_ECOLI hmoment swissprot:PPPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PPPA_ECOLI iep swissprot:PPPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PPPA_ECOLI inforesidue swissprot:PPPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PPPA_ECOLI octanol swissprot:PPPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PPPA_ECOLI pepcoil swissprot:PPPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PPPA_ECOLI pepdigest swissprot:PPPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PPPA_ECOLI pepinfo swissprot:PPPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PPPA_ECOLI pepnet swissprot:PPPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PPPA_ECOLI pepstats swissprot:PPPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PPPA_ECOLI pepwheel swissprot:PPPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PPPA_ECOLI pepwindow swissprot:PPPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PPPA_ECOLI sigcleave swissprot:PPPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PPPA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260666 94 # EcoGene EG13385 yeeR # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # Organism YEER_ECOLI Escherichia coli (strain K12) # PATRIC 32119335 VBIEscCol129921_2077 # PIR H64964 H64964 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEER_ECOLI Inner membrane protein YeeR # RefSeq NP_416505 NC_000913.3 # SUBCELLULAR LOCATION YEER_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG ENOG4108PZQ Bacteria # eggNOG ENOG410XXEN LUCA BLAST swissprot:YEER_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEER_ECOLI BioCyc ECOL316407:JW1983-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1983-MONOMER BioCyc EcoCyc:G7081-MONOMER http://biocyc.org/getid?id=EcoCyc:G7081-MONOMER DIP DIP-11864N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11864N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3166 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3166 EcoGene EG13385 http://www.ecogene.org/geneInfo.php?eg_id=EG13385 EnsemblBacteria AAC75062 http://www.ensemblgenomes.org/id/AAC75062 EnsemblBacteria AAC75062 http://www.ensemblgenomes.org/id/AAC75062 EnsemblBacteria BAE76563 http://www.ensemblgenomes.org/id/BAE76563 EnsemblBacteria BAE76563 http://www.ensemblgenomes.org/id/BAE76563 EnsemblBacteria BAE76563 http://www.ensemblgenomes.org/id/BAE76563 EnsemblBacteria b2001 http://www.ensemblgenomes.org/id/b2001 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 946512 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946512 IntAct P76361 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76361* KEGG_Gene ecj:JW1983 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1983 KEGG_Gene eco:b2001 http://www.genome.jp/dbget-bin/www_bget?eco:b2001 PSORT swissprot:YEER_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEER_ECOLI PSORT-B swissprot:YEER_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEER_ECOLI PSORT2 swissprot:YEER_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEER_ECOLI Phobius swissprot:YEER_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEER_ECOLI ProteinModelPortal P76361 http://www.proteinmodelportal.org/query/uniprot/P76361 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416505 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416505 SMR P76361 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76361 STRING 511145.b2001 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2001&targetmode=cogs UniProtKB YEER_ECOLI http://www.uniprot.org/uniprot/YEER_ECOLI UniProtKB-AC P76361 http://www.uniprot.org/uniprot/P76361 charge swissprot:YEER_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEER_ECOLI eggNOG ENOG4108PZQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108PZQ eggNOG ENOG410XXEN http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XXEN epestfind swissprot:YEER_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEER_ECOLI garnier swissprot:YEER_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEER_ECOLI helixturnhelix swissprot:YEER_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEER_ECOLI hmoment swissprot:YEER_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEER_ECOLI iep swissprot:YEER_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEER_ECOLI inforesidue swissprot:YEER_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEER_ECOLI octanol swissprot:YEER_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEER_ECOLI pepcoil swissprot:YEER_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEER_ECOLI pepdigest swissprot:YEER_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEER_ECOLI pepinfo swissprot:YEER_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEER_ECOLI pepnet swissprot:YEER_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEER_ECOLI pepstats swissprot:YEER_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEER_ECOLI pepwheel swissprot:YEER_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEER_ECOLI pepwindow swissprot:YEER_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEER_ECOLI sigcleave swissprot:YEER_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEER_ECOLI ## Database ID URL or Descriptions # AltName YBFD_ECOLI ORF-H3 # BioGrid 4261600 155 # EcoGene EG11524 ybfD # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # IntAct P28916 5 # InterPro IPR002559 Transposase_11 # InterPro IPR032806 YbfD_N # Organism YBFD_ECOLI Escherichia coli (strain K12) # PATRIC 32116607 VBIEscCol129921_0736 # PIR A64806 A64806 # Pfam PF01609 DDE_Tnp_1 # Pfam PF13808 DDE_Tnp_1_assoc # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBFD_ECOLI H repeat-associated protein YbfD # RefSeq NP_415234 NC_000913.3 # RefSeq WP_000420862 NZ_LN832404.1 # SIMILARITY Belongs to the transposase 11 family. {ECO 0000305}. # eggNOG COG5433 LUCA # eggNOG ENOG410600T Bacteria BLAST swissprot:YBFD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBFD_ECOLI BioCyc ECOL316407:JW0696-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0696-MONOMER BioCyc EcoCyc:EG11524-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11524-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L02373 http://www.ebi.ac.uk/ena/data/view/L02373 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U15125 http://www.ebi.ac.uk/ena/data/view/U15125 EchoBASE EB1486 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1486 EcoGene EG11524 http://www.ecogene.org/geneInfo.php?eg_id=EG11524 EnsemblBacteria AAC73800 http://www.ensemblgenomes.org/id/AAC73800 EnsemblBacteria AAC73800 http://www.ensemblgenomes.org/id/AAC73800 EnsemblBacteria BAA35365 http://www.ensemblgenomes.org/id/BAA35365 EnsemblBacteria BAA35365 http://www.ensemblgenomes.org/id/BAA35365 EnsemblBacteria BAA35365 http://www.ensemblgenomes.org/id/BAA35365 EnsemblBacteria b0706 http://www.ensemblgenomes.org/id/b0706 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GeneID 945176 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945176 HOGENOM HOG000042098 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000042098&db=HOGENOM6 InParanoid P28916 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P28916 IntAct P28916 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P28916* InterPro IPR002559 http://www.ebi.ac.uk/interpro/entry/IPR002559 InterPro IPR032806 http://www.ebi.ac.uk/interpro/entry/IPR032806 KEGG_Gene ecj:JW0696 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0696 KEGG_Gene eco:b0706 http://www.genome.jp/dbget-bin/www_bget?eco:b0706 OMA WTRELTI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WTRELTI PSORT swissprot:YBFD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBFD_ECOLI PSORT-B swissprot:YBFD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBFD_ECOLI PSORT2 swissprot:YBFD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBFD_ECOLI Pfam PF01609 http://pfam.xfam.org/family/PF01609 Pfam PF13808 http://pfam.xfam.org/family/PF13808 Phobius swissprot:YBFD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBFD_ECOLI PhylomeDB P28916 http://phylomedb.org/?seqid=P28916 ProteinModelPortal P28916 http://www.proteinmodelportal.org/query/uniprot/P28916 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7868617 http://www.ncbi.nlm.nih.gov/pubmed/7868617 PubMed 8387990 http://www.ncbi.nlm.nih.gov/pubmed/8387990 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415234 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415234 RefSeq WP_000420862 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000420862 SMR P28916 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P28916 STRING 511145.b0706 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0706&targetmode=cogs UniProtKB YBFD_ECOLI http://www.uniprot.org/uniprot/YBFD_ECOLI UniProtKB-AC P28916 http://www.uniprot.org/uniprot/P28916 charge swissprot:YBFD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBFD_ECOLI eggNOG COG5433 http://eggnogapi.embl.de/nog_data/html/tree/COG5433 eggNOG ENOG410600T http://eggnogapi.embl.de/nog_data/html/tree/ENOG410600T epestfind swissprot:YBFD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBFD_ECOLI garnier swissprot:YBFD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBFD_ECOLI helixturnhelix swissprot:YBFD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBFD_ECOLI hmoment swissprot:YBFD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBFD_ECOLI iep swissprot:YBFD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBFD_ECOLI inforesidue swissprot:YBFD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBFD_ECOLI octanol swissprot:YBFD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBFD_ECOLI pepcoil swissprot:YBFD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBFD_ECOLI pepdigest swissprot:YBFD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBFD_ECOLI pepinfo swissprot:YBFD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBFD_ECOLI pepnet swissprot:YBFD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBFD_ECOLI pepstats swissprot:YBFD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBFD_ECOLI pepwheel swissprot:YBFD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBFD_ECOLI pepwindow swissprot:YBFD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBFD_ECOLI sigcleave swissprot:YBFD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBFD_ECOLI ## Database ID URL or Descriptions # AltName FADK_ECOLI Acyl-CoA synthetase # BIOPHYSICOCHEMICAL PROPERTIES pH dependence: Optimum pH is 7.7 - 8.2. {ECO 0000269|PubMed:15213221}; # BioGrid 4260285 308 # CATALYTIC ACTIVITY ATP + a short-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA. {ECO:0000269|PubMed 15213221}. # EcoGene EG12357 fadK # FUNCTION FADK_ECOLI Catalyzes the esterification, concomitant with transport, of exogenous fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. It has a low activity on medium or long chain fatty acids and is maximally active on C6 0 and C8 0 substrates (PubMed 15213221). FadK is not expressed under aerobic growth conditions and it could functionally replace FadD under anaerobic conditions (PubMed 15213221). {ECO 0000269|PubMed 15213221}. # GO_component GO:0016020 membrane; IEA:UniProtKB-SubCell. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0031956 medium-chain fatty acid-CoA ligase activity; IDA:EcoCyc. # GO_process GO:0006631 fatty acid metabolic process; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0044281 small molecule metabolic process # INDUCTION FADK_ECOLI Expression independent of FadR (PubMed 12535077). FadK is not expressed under aerobic growth conditions, the levels of anaerobic expression vary with the terminal electron acceptor, with more expression during growth on fumarate than on nitrate (at protein level) (PubMed 15213221). {ECO 0000269|PubMed 12535077, ECO 0000269|PubMed 15213221}. # InterPro IPR000873 AMP-dep_Synth/Lig # InterPro IPR020845 AMP-binding_CS # InterPro IPR025110 AMP-bd_C # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01004 Lipid biosynthesis proteins # MISCELLANEOUS Probably starts on Met-1; overexpressed protein starting at Met-19 has lower activity, forms aggregates during reaction and is unstable in storage at -80 degrees Celsius (PubMed:15213221). {ECO 0000269|PubMed:15213221}. # Organism FADK_ECOLI Escherichia coli (strain K12) # PATRIC 32118708 VBIEscCol129921_1772 # PIR E64928 E64928 # PROSITE PS00455 AMP_BINDING # Pfam PF00501 AMP-binding # Pfam PF13193 AMP-binding_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FADK_ECOLI Short-chain-fatty-acid--CoA ligase # RefSeq NP_416216 NC_000913.3 # SEQUENCE CAUTION Sequence=AAC74771.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=M69116; Type=Frameshift; Positions=Several; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ATP-dependent AMP-binding enzyme family. {ECO 0000305}. # SUBCELLULAR LOCATION FADK_ECOLI Membrane; Peripheral membrane protein. Note=Partially membrane-associated. {ECO 0000305|PubMed 15213221}. # SUBUNIT Homodimer. {ECO 0000250}. # eggNOG COG0318 LUCA # eggNOG ENOG4105CEY Bacteria BLAST swissprot:FADK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FADK_ECOLI BioCyc ECOL316407:JW5910-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5910-MONOMER BioCyc EcoCyc:EG12357-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12357-MONOMER BioCyc MetaCyc:EG12357-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12357-MONOMER COG COG0318 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0318 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2003.03341.x http://dx.doi.org/10.1046/j.1365-2958.2003.03341.x DOI 10.1074/jbc.M405233200 http://dx.doi.org/10.1074/jbc.M405233200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.2.1.- {ECO:0000269|PubMed:15213221} http://www.genome.jp/dbget-bin/www_bget?EC:6.2.1.- {ECO:0000269|PubMed:15213221} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M69116 http://www.ebi.ac.uk/ena/data/view/M69116 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 6.2.1.- {ECO:0000269|PubMed:15213221} http://enzyme.expasy.org/EC/6.2.1.- {ECO:0000269|PubMed:15213221} EchoBASE EB2260 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2260 EcoGene EG12357 http://www.ecogene.org/geneInfo.php?eg_id=EG12357 EnsemblBacteria AAC74771 http://www.ensemblgenomes.org/id/AAC74771 EnsemblBacteria AAC74771 http://www.ensemblgenomes.org/id/AAC74771 EnsemblBacteria BAA15470 http://www.ensemblgenomes.org/id/BAA15470 EnsemblBacteria BAA15470 http://www.ensemblgenomes.org/id/BAA15470 EnsemblBacteria BAA15470 http://www.ensemblgenomes.org/id/BAA15470 EnsemblBacteria b1701 http://www.ensemblgenomes.org/id/b1701 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0031956 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031956 GO_process GO:0006631 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006631 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 946213 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946213 HOGENOM HOG000230000 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230000&db=HOGENOM6 InParanoid P38135 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P38135 IntEnz 6.2.1.- {ECO:0000269|PubMed:15213221} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.2.1.- {ECO:0000269|PubMed:15213221} InterPro IPR000873 http://www.ebi.ac.uk/interpro/entry/IPR000873 InterPro IPR020845 http://www.ebi.ac.uk/interpro/entry/IPR020845 InterPro IPR025110 http://www.ebi.ac.uk/interpro/entry/IPR025110 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01004 http://www.genome.jp/dbget-bin/www_bget?ko01004 KEGG_Gene ecj:JW5910 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5910 KEGG_Gene eco:b1701 http://www.genome.jp/dbget-bin/www_bget?eco:b1701 KEGG_Orthology KO:K12507 http://www.genome.jp/dbget-bin/www_bget?KO:K12507 OMA GKLMPHV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GKLMPHV PROSITE PS00455 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00455 PSORT swissprot:FADK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FADK_ECOLI PSORT-B swissprot:FADK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FADK_ECOLI PSORT2 swissprot:FADK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FADK_ECOLI Pfam PF00501 http://pfam.xfam.org/family/PF00501 Pfam PF13193 http://pfam.xfam.org/family/PF13193 Phobius swissprot:FADK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FADK_ECOLI ProteinModelPortal P38135 http://www.proteinmodelportal.org/query/uniprot/P38135 PubMed 12535077 http://www.ncbi.nlm.nih.gov/pubmed/12535077 PubMed 15213221 http://www.ncbi.nlm.nih.gov/pubmed/15213221 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416216 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416216 STRING 511145.b1701 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1701&targetmode=cogs STRING COG0318 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0318&targetmode=cogs UniProtKB FADK_ECOLI http://www.uniprot.org/uniprot/FADK_ECOLI UniProtKB-AC P38135 http://www.uniprot.org/uniprot/P38135 charge swissprot:FADK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FADK_ECOLI eggNOG COG0318 http://eggnogapi.embl.de/nog_data/html/tree/COG0318 eggNOG ENOG4105CEY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CEY epestfind swissprot:FADK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FADK_ECOLI garnier swissprot:FADK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FADK_ECOLI helixturnhelix swissprot:FADK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FADK_ECOLI hmoment swissprot:FADK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FADK_ECOLI iep swissprot:FADK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FADK_ECOLI inforesidue swissprot:FADK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FADK_ECOLI octanol swissprot:FADK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FADK_ECOLI pepcoil swissprot:FADK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FADK_ECOLI pepdigest swissprot:FADK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FADK_ECOLI pepinfo swissprot:FADK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FADK_ECOLI pepnet swissprot:FADK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FADK_ECOLI pepstats swissprot:FADK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FADK_ECOLI pepwheel swissprot:FADK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FADK_ECOLI pepwindow swissprot:FADK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FADK_ECOLI sigcleave swissprot:FADK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FADK_ECOLI ## Database ID URL or Descriptions # AltName MLC_ECOLI Making large colonies protein # BioGrid 4259119 23 # EcoGene EG13156 mlc # FUNCTION MLC_ECOLI Transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. Regulates the expression of malT. {ECO 0000269|PubMed 10464268, ECO 0000269|PubMed 11361067}. # GO_component GO:0005737 cytoplasm; TAS:EcoCyc. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0005975 carbohydrate metabolic process; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # INTERACTION MLC_ECOLI P76346 mtfA; NbExp=2; IntAct=EBI-1116104, EBI-1126682; # IntAct P50456 9 # InterPro IPR000600 ROK # InterPro IPR011991 WHTH_DNA-bd_dom # KEGG_Brite ko03000 Transcription factors # Organism MLC_ECOLI Escherichia coli (strain K12) # PATRIC 32118490 VBIEscCol129921_1665 # PDB 1Z6R X-ray; 2.70 A; A/B/C/D=1-406 # PDB 3BP8 X-ray; 2.85 A; A/B=1-406 # PIR D64915 D64915 # Pfam PF00480 ROK # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MLC_ECOLI Protein mlc # RefSeq NP_416111 NC_000913.3 # RefSeq WP_000225262 NZ_LN832404.1 # SIMILARITY Belongs to the ROK (NagC/XylR) family. {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 15929984}. # SUPFAM SSF46785 SSF46785 # eggNOG COG1940 LUCA # eggNOG ENOG4105DAG Bacteria BLAST swissprot:MLC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MLC_ECOLI BioCyc ECOL316407:JW1586-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1586-MONOMER BioCyc EcoCyc:PD01896 http://biocyc.org/getid?id=EcoCyc:PD01896 COG COG1940 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1940 DIP DIP-10219N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10219N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.274.36.25398 http://dx.doi.org/10.1074/jbc.274.36.25398 DOI 10.1074/jbc.M504215200 http://dx.doi.org/10.1074/jbc.M504215200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1271/bbb.59.256 http://dx.doi.org/10.1271/bbb.59.256 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D32222 http://www.ebi.ac.uk/ena/data/view/D32222 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2950 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2950 EcoGene EG13156 http://www.ecogene.org/geneInfo.php?eg_id=EG13156 EnsemblBacteria AAC74666 http://www.ensemblgenomes.org/id/AAC74666 EnsemblBacteria AAC74666 http://www.ensemblgenomes.org/id/AAC74666 EnsemblBacteria BAA15318 http://www.ensemblgenomes.org/id/BAA15318 EnsemblBacteria BAA15318 http://www.ensemblgenomes.org/id/BAA15318 EnsemblBacteria BAA15318 http://www.ensemblgenomes.org/id/BAA15318 EnsemblBacteria b1594 http://www.ensemblgenomes.org/id/b1594 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 945510 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945510 HOGENOM HOG000275182 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275182&db=HOGENOM6 InParanoid P50456 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P50456 IntAct P50456 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P50456* InterPro IPR000600 http://www.ebi.ac.uk/interpro/entry/IPR000600 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW1586 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1586 KEGG_Gene eco:b1594 http://www.genome.jp/dbget-bin/www_bget?eco:b1594 KEGG_Orthology KO:K15545 http://www.genome.jp/dbget-bin/www_bget?KO:K15545 OMA LIEAHLI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LIEAHLI PDB 1Z6R http://www.ebi.ac.uk/pdbe-srv/view/entry/1Z6R PDB 3BP8 http://www.ebi.ac.uk/pdbe-srv/view/entry/3BP8 PDBsum 1Z6R http://www.ebi.ac.uk/pdbsum/1Z6R PDBsum 3BP8 http://www.ebi.ac.uk/pdbsum/3BP8 PSORT swissprot:MLC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MLC_ECOLI PSORT-B swissprot:MLC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MLC_ECOLI PSORT2 swissprot:MLC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MLC_ECOLI Pfam PF00480 http://pfam.xfam.org/family/PF00480 Phobius swissprot:MLC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MLC_ECOLI PhylomeDB P50456 http://phylomedb.org/?seqid=P50456 ProteinModelPortal P50456 http://www.proteinmodelportal.org/query/uniprot/P50456 PubMed 10464268 http://www.ncbi.nlm.nih.gov/pubmed/10464268 PubMed 11361067 http://www.ncbi.nlm.nih.gov/pubmed/11361067 PubMed 15929984 http://www.ncbi.nlm.nih.gov/pubmed/15929984 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7766024 http://www.ncbi.nlm.nih.gov/pubmed/7766024 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416111 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416111 RefSeq WP_000225262 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000225262 SMR P50456 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P50456 STRING 511145.b1594 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1594&targetmode=cogs STRING COG1940 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1940&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB MLC_ECOLI http://www.uniprot.org/uniprot/MLC_ECOLI UniProtKB-AC P50456 http://www.uniprot.org/uniprot/P50456 charge swissprot:MLC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MLC_ECOLI eggNOG COG1940 http://eggnogapi.embl.de/nog_data/html/tree/COG1940 eggNOG ENOG4105DAG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DAG epestfind swissprot:MLC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MLC_ECOLI garnier swissprot:MLC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MLC_ECOLI helixturnhelix swissprot:MLC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MLC_ECOLI hmoment swissprot:MLC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MLC_ECOLI iep swissprot:MLC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MLC_ECOLI inforesidue swissprot:MLC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MLC_ECOLI octanol swissprot:MLC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MLC_ECOLI pepcoil swissprot:MLC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MLC_ECOLI pepdigest swissprot:MLC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MLC_ECOLI pepinfo swissprot:MLC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MLC_ECOLI pepnet swissprot:MLC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MLC_ECOLI pepstats swissprot:MLC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MLC_ECOLI pepwheel swissprot:MLC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MLC_ECOLI pepwindow swissprot:MLC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MLC_ECOLI sigcleave swissprot:MLC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MLC_ECOLI ## Database ID URL or Descriptions # EcoGene EG14451 ykfM # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006974 cellular response to DNA damage stimulus; IMP:EcoCyc. # GO_process GO:0046677 response to antibiotic; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # Organism YKFM_ECOLI Escherichia coli (strain K12) # Proteomes UP000000625 Chromosome # RecName YKFM_ECOLI Uncharacterized protein YkfM # RefSeq WP_001236645 NZ_LN832404.1 # RefSeq YP_001165307 NC_000913.3 # SUBCELLULAR LOCATION YKFM_ECOLI Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. BLAST swissprot:YKFM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YKFM_ECOLI BioCyc EcoCyc:MONOMER0-2812 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2812 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EcoGene EG14451 http://www.ecogene.org/geneInfo.php?eg_id=EG14451 EnsemblBacteria ABP93434 http://www.ensemblgenomes.org/id/ABP93434 EnsemblBacteria ABP93434 http://www.ensemblgenomes.org/id/ABP93434 EnsemblBacteria b4586 http://www.ensemblgenomes.org/id/b4586 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 5061498 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5061498 HOGENOM HOG000068955 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000068955&db=HOGENOM6 KEGG_Gene eco:b4586 http://www.genome.jp/dbget-bin/www_bget?eco:b4586 OMA KSHNIIM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KSHNIIM PSORT swissprot:YKFM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YKFM_ECOLI PSORT-B swissprot:YKFM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YKFM_ECOLI PSORT2 swissprot:YKFM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YKFM_ECOLI Phobius swissprot:YKFM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YKFM_ECOLI ProteinModelPortal A5A605 http://www.proteinmodelportal.org/query/uniprot/A5A605 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001236645 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001236645 RefSeq YP_001165307 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001165307 STRING 511145.b4586 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4586&targetmode=cogs UniProtKB YKFM_ECOLI http://www.uniprot.org/uniprot/YKFM_ECOLI UniProtKB-AC A5A605 http://www.uniprot.org/uniprot/A5A605 charge swissprot:YKFM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YKFM_ECOLI epestfind swissprot:YKFM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YKFM_ECOLI garnier swissprot:YKFM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YKFM_ECOLI helixturnhelix swissprot:YKFM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YKFM_ECOLI hmoment swissprot:YKFM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YKFM_ECOLI iep swissprot:YKFM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YKFM_ECOLI inforesidue swissprot:YKFM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YKFM_ECOLI octanol swissprot:YKFM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YKFM_ECOLI pepcoil swissprot:YKFM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YKFM_ECOLI pepdigest swissprot:YKFM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YKFM_ECOLI pepinfo swissprot:YKFM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YKFM_ECOLI pepnet swissprot:YKFM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YKFM_ECOLI pepstats swissprot:YKFM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YKFM_ECOLI pepwheel swissprot:YKFM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YKFM_ECOLI pepwindow swissprot:YKFM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YKFM_ECOLI sigcleave swissprot:YKFM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YKFM_ECOLI ## Database ID URL or Descriptions # BioGrid 4262639 8 # CATALYTIC ACTIVITY SQUT_ECOLI 6-deoxy-6-sulfo-D-fructose 1-phosphate = glycerone phosphate + 2-hydroxy-3-oxopropane-1-sulfonate. {ECO 0000255|HAMAP-Rule MF_01912, ECO 0000269|PubMed 24463506}. # DISRUPTION PHENOTYPE Mutant fails to grow on sulfoquinovose as a sole carbon source. {ECO:0000269|PubMed 24463506}. # EcoGene EG11846 yihT # FUNCTION SQUT_ECOLI Cleaves 6-deoxy-6-sulfo-D-fructose 1-phosphate (SFP) to form dihydroxyacetone phosphate (DHAP) and 3-sulfolactaldehyde (SLA). {ECO 0000255|HAMAP-Rule MF_01912, ECO 0000269|PubMed 24463506}. # GO_function GO:0061595 6-deoxy-6-sulfofructose-1-phosphate aldolase activity; IDA:EcoCyc. # GO_process GO:1902777 6-sulfoquinovose(1-) catabolic process; IMP:EcoCyc. # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009056 catabolic process # Gene3D 3.20.20.70 -; 1. # HAMAP MF_01912 SFP_aldolase # INDUCTION Induced during growth with sulfoquinovose. {ECO:0000269|PubMed 24463506}. # IntAct P32141 5 # InterPro IPR002915 DeoC/FbaB/lacD_aldolase # InterPro IPR013785 Aldolase_TIM # InterPro IPR017291 SFP_aldolase_YihT # KEGG_Brite ko01000 Enzymes # Organism SQUT_ECOLI Escherichia coli (strain K12) # PATRIC 32123265 VBIEscCol129921_3993 # PIR S40825 S40825 # PIRSF PIRSF037840 Aldolase_YihT # Pfam PF01791 DeoC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Sulfofructosephosphate aldolase {ECO:0000255|HAMAP-Rule MF_01912} # RefSeq NP_418317 NC_000913.3 # RefSeq WP_001046453 NZ_LN832404.1 # SIMILARITY Belongs to the aldolase LacD family. {ECO:0000255|HAMAP-Rule MF_01912}. # SMART SM01133 DeoC # eggNOG COG3684 LUCA # eggNOG ENOG4105D2M Bacteria BLAST swissprot:SQUT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SQUT_ECOLI BioCyc ECOL316407:JW3852-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3852-MONOMER BioCyc EcoCyc:EG11846-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11846-MONOMER BioCyc MetaCyc:EG11846-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11846-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature12947 http://dx.doi.org/10.1038/nature12947 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.1.2.57 {ECO:0000255|HAMAP-Rule:MF_01912} http://www.genome.jp/dbget-bin/www_bget?EC:4.1.2.57 {ECO:0000255|HAMAP-Rule:MF_01912} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 4.1.2.57 {ECO:0000255|HAMAP-Rule:MF_01912} http://enzyme.expasy.org/EC/4.1.2.57 {ECO:0000255|HAMAP-Rule:MF_01912} EchoBASE EB1792 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1792 EcoGene EG11846 http://www.ecogene.org/geneInfo.php?eg_id=EG11846 EnsemblBacteria AAD13443 http://www.ensemblgenomes.org/id/AAD13443 EnsemblBacteria AAD13443 http://www.ensemblgenomes.org/id/AAD13443 EnsemblBacteria BAE77428 http://www.ensemblgenomes.org/id/BAE77428 EnsemblBacteria BAE77428 http://www.ensemblgenomes.org/id/BAE77428 EnsemblBacteria BAE77428 http://www.ensemblgenomes.org/id/BAE77428 EnsemblBacteria b3881 http://www.ensemblgenomes.org/id/b3881 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0061595 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061595 GO_process GO:1902777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902777 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 948373 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948373 HAMAP MF_01912 http://hamap.expasy.org/unirule/MF_01912 HOGENOM HOG000244296 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000244296&db=HOGENOM6 InParanoid P32141 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32141 IntAct P32141 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32141* IntEnz 4.1.2.57 {ECO:0000255|HAMAP-Rule:MF_01912} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.2.57 {ECO:0000255|HAMAP-Rule:MF_01912} InterPro IPR002915 http://www.ebi.ac.uk/interpro/entry/IPR002915 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR017291 http://www.ebi.ac.uk/interpro/entry/IPR017291 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3852 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3852 KEGG_Gene eco:b3881 http://www.genome.jp/dbget-bin/www_bget?eco:b3881 KEGG_Orthology KO:K01671 http://www.genome.jp/dbget-bin/www_bget?KO:K01671 OMA LCQIAEN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LCQIAEN PSORT swissprot:SQUT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SQUT_ECOLI PSORT-B swissprot:SQUT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SQUT_ECOLI PSORT2 swissprot:SQUT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SQUT_ECOLI Pfam PF01791 http://pfam.xfam.org/family/PF01791 Phobius swissprot:SQUT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SQUT_ECOLI PhylomeDB P32141 http://phylomedb.org/?seqid=P32141 ProteinModelPortal P32141 http://www.proteinmodelportal.org/query/uniprot/P32141 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 24463506 http://www.ncbi.nlm.nih.gov/pubmed/24463506 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418317 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418317 RefSeq WP_001046453 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001046453 SMART SM01133 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01133 SMR P32141 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32141 STRING 511145.b3881 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3881&targetmode=cogs UniProtKB SQUT_ECOLI http://www.uniprot.org/uniprot/SQUT_ECOLI UniProtKB-AC P32141 http://www.uniprot.org/uniprot/P32141 charge swissprot:SQUT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SQUT_ECOLI eggNOG COG3684 http://eggnogapi.embl.de/nog_data/html/tree/COG3684 eggNOG ENOG4105D2M http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D2M epestfind swissprot:SQUT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SQUT_ECOLI garnier swissprot:SQUT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SQUT_ECOLI helixturnhelix swissprot:SQUT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SQUT_ECOLI hmoment swissprot:SQUT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SQUT_ECOLI iep swissprot:SQUT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SQUT_ECOLI inforesidue swissprot:SQUT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SQUT_ECOLI octanol swissprot:SQUT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SQUT_ECOLI pepcoil swissprot:SQUT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SQUT_ECOLI pepdigest swissprot:SQUT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SQUT_ECOLI pepinfo swissprot:SQUT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SQUT_ECOLI pepnet swissprot:SQUT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SQUT_ECOLI pepstats swissprot:SQUT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SQUT_ECOLI pepwheel swissprot:SQUT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SQUT_ECOLI pepwindow swissprot:SQUT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SQUT_ECOLI sigcleave swissprot:SQUT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SQUT_ECOLI ## Database ID URL or Descriptions # Organism YUAG_ECOLI Escherichia coli (strain K12) # RecName YUAG_ECOLI Uncharacterized protein YuaG # RefSeq NP_061397 NC_002483.1 # RefSeq WP_010892524 NC_002483.1 BLAST swissprot:YUAG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YUAG_ECOLI EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1263529 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263529 PSORT swissprot:YUAG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YUAG_ECOLI PSORT-B swissprot:YUAG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YUAG_ECOLI PSORT2 swissprot:YUAG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YUAG_ECOLI Phobius swissprot:YUAG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YUAG_ECOLI ProteinModelPortal Q9JMT2 http://www.proteinmodelportal.org/query/uniprot/Q9JMT2 RefSeq NP_061397 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061397 RefSeq WP_010892524 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_010892524 UniProtKB YUAG_ECOLI http://www.uniprot.org/uniprot/YUAG_ECOLI UniProtKB-AC Q9JMT2 http://www.uniprot.org/uniprot/Q9JMT2 charge swissprot:YUAG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YUAG_ECOLI epestfind swissprot:YUAG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YUAG_ECOLI garnier swissprot:YUAG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YUAG_ECOLI helixturnhelix swissprot:YUAG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YUAG_ECOLI hmoment swissprot:YUAG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YUAG_ECOLI iep swissprot:YUAG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YUAG_ECOLI inforesidue swissprot:YUAG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YUAG_ECOLI octanol swissprot:YUAG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YUAG_ECOLI pepcoil swissprot:YUAG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YUAG_ECOLI pepdigest swissprot:YUAG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YUAG_ECOLI pepinfo swissprot:YUAG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YUAG_ECOLI pepnet swissprot:YUAG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YUAG_ECOLI pepstats swissprot:YUAG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YUAG_ECOLI pepwheel swissprot:YUAG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YUAG_ECOLI pepwindow swissprot:YUAG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YUAG_ECOLI sigcleave swissprot:YUAG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YUAG_ECOLI ## Database ID URL or Descriptions # BioGrid 4260103 9 # EcoGene EG11516 ycgB # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_process GO:0006950 response to stress # IntAct P29013 4 # InterPro IPR007390 Spore_V_R # Organism YCGB_ECOLI Escherichia coli (strain K12) # PATRIC 32117622 VBIEscCol129921_1233 # PIR A64865 A64865 # Pfam PF04293 SpoVR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCGB_ECOLI Uncharacterized protein YcgB # RefSeq NP_415706 NC_000913.3 # RefSeq WP_000190854 NZ_LN832404.1 # SIMILARITY To B.subtilis SpoVR. {ECO 0000305}. # eggNOG COG2719 LUCA # eggNOG ENOG4105ED1 Bacteria BLAST swissprot:YCGB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCGB_ECOLI BioCyc ECOL316407:JW1177-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1177-MONOMER BioCyc EcoCyc:EG11516-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11516-MONOMER DIP DIP-11550N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11550N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L02948 http://www.ebi.ac.uk/ena/data/view/L02948 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1478 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1478 EcoGene EG11516 http://www.ecogene.org/geneInfo.php?eg_id=EG11516 EnsemblBacteria AAC74272 http://www.ensemblgenomes.org/id/AAC74272 EnsemblBacteria AAC74272 http://www.ensemblgenomes.org/id/AAC74272 EnsemblBacteria BAA36043 http://www.ensemblgenomes.org/id/BAA36043 EnsemblBacteria BAA36043 http://www.ensemblgenomes.org/id/BAA36043 EnsemblBacteria BAA36043 http://www.ensemblgenomes.org/id/BAA36043 EnsemblBacteria b1188 http://www.ensemblgenomes.org/id/b1188 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 946365 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946365 HOGENOM HOG000260104 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260104&db=HOGENOM6 InParanoid P29013 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P29013 IntAct P29013 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P29013* InterPro IPR007390 http://www.ebi.ac.uk/interpro/entry/IPR007390 KEGG_Gene ecj:JW1177 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1177 KEGG_Gene eco:b1188 http://www.genome.jp/dbget-bin/www_bget?eco:b1188 OMA FNDLWRT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FNDLWRT PSORT swissprot:YCGB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCGB_ECOLI PSORT-B swissprot:YCGB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCGB_ECOLI PSORT2 swissprot:YCGB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCGB_ECOLI Pfam PF04293 http://pfam.xfam.org/family/PF04293 Phobius swissprot:YCGB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCGB_ECOLI PhylomeDB P29013 http://phylomedb.org/?seqid=P29013 ProteinModelPortal P29013 http://www.proteinmodelportal.org/query/uniprot/P29013 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7906689 http://www.ncbi.nlm.nih.gov/pubmed/7906689 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415706 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415706 RefSeq WP_000190854 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000190854 STRING 511145.b1188 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1188&targetmode=cogs UniProtKB YCGB_ECOLI http://www.uniprot.org/uniprot/YCGB_ECOLI UniProtKB-AC P29013 http://www.uniprot.org/uniprot/P29013 charge swissprot:YCGB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCGB_ECOLI eggNOG COG2719 http://eggnogapi.embl.de/nog_data/html/tree/COG2719 eggNOG ENOG4105ED1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ED1 epestfind swissprot:YCGB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCGB_ECOLI garnier swissprot:YCGB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCGB_ECOLI helixturnhelix swissprot:YCGB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCGB_ECOLI hmoment swissprot:YCGB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCGB_ECOLI iep swissprot:YCGB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCGB_ECOLI inforesidue swissprot:YCGB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCGB_ECOLI octanol swissprot:YCGB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCGB_ECOLI pepcoil swissprot:YCGB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCGB_ECOLI pepdigest swissprot:YCGB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCGB_ECOLI pepinfo swissprot:YCGB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCGB_ECOLI pepnet swissprot:YCGB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCGB_ECOLI pepstats swissprot:YCGB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCGB_ECOLI pepwheel swissprot:YCGB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCGB_ECOLI pepwindow swissprot:YCGB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCGB_ECOLI sigcleave swissprot:YCGB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCGB_ECOLI ## Database ID URL or Descriptions # AltName ZNTR_ECOLI Zn(II)-responsive regulator of zntA # BioGrid 4263395 8 # EcoGene EG11969 zntR # FUNCTION ZNTR_ECOLI Zinc-responsive transcriptional regulator of zntA. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # IntAct P0ACS5 5 # InterPro IPR000551 MerR-type_HTH_dom # InterPro IPR009061 DNA-bd_dom_put # InterPro IPR011788 ZntR # KEGG_Brite ko03000 Transcription factors # Organism ZNTR_ECOLI Escherichia coli (strain K12) # PATRIC 32122016 VBIEscCol129921_3385 # PDB 1Q08 X-ray; 1.90 A; A/B=43-141 # PDB 1Q09 X-ray; 2.50 A; A=43-141 # PDB 1Q0A X-ray; 2.00 A; A/B=43-141 # PIR I67892 I67892 # PRINTS PR00040 HTHMERR # PROSITE PS00552 HTH_MERR_1 # PROSITE PS50937 HTH_MERR_2 # Pfam PF13411 MerR_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ZNTR_ECOLI HTH-type transcriptional regulator ZntR # RefSeq NP_417751 NC_000913.3 # RefSeq WP_000285607 NZ_LN832404.1 # SIMILARITY Contains 1 HTH merR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00254}. # SMART SM00422 HTH_MERR # SUBUNIT ZNTR_ECOLI Homodimer. # SUPFAM SSF46955 SSF46955 # TIGRFAMs TIGR02043 ZntR # eggNOG COG0789 LUCA # eggNOG ENOG4105W1Y Bacteria BLAST swissprot:ZNTR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ZNTR_ECOLI BioCyc ECOL316407:JW3254-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3254-MONOMER BioCyc EcoCyc:EG11969-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11969-MONOMER COG COG0789 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0789 DIP DIP-48253N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48253N DOI 10.1016/0378-1119(94)90847-8 http://dx.doi.org/10.1016/0378-1119(94)90847-8 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1999.01229.x http://dx.doi.org/10.1046/j.1365-2958.1999.01229.x DOI 10.1126/science.1085950 http://dx.doi.org/10.1126/science.1085950 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L29458 http://www.ebi.ac.uk/ena/data/view/L29458 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB1912 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1912 EcoGene EG11969 http://www.ecogene.org/geneInfo.php?eg_id=EG11969 EnsemblBacteria AAC76317 http://www.ensemblgenomes.org/id/AAC76317 EnsemblBacteria AAC76317 http://www.ensemblgenomes.org/id/AAC76317 EnsemblBacteria BAE77999 http://www.ensemblgenomes.org/id/BAE77999 EnsemblBacteria BAE77999 http://www.ensemblgenomes.org/id/BAE77999 EnsemblBacteria BAE77999 http://www.ensemblgenomes.org/id/BAE77999 EnsemblBacteria b3292 http://www.ensemblgenomes.org/id/b3292 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 947786 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947786 HOGENOM HOG000266084 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000266084&db=HOGENOM6 InParanoid P0ACS5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACS5 IntAct P0ACS5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACS5* InterPro IPR000551 http://www.ebi.ac.uk/interpro/entry/IPR000551 InterPro IPR009061 http://www.ebi.ac.uk/interpro/entry/IPR009061 InterPro IPR011788 http://www.ebi.ac.uk/interpro/entry/IPR011788 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW3254 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3254 KEGG_Gene eco:b3292 http://www.genome.jp/dbget-bin/www_bget?eco:b3292 KEGG_Orthology KO:K13638 http://www.genome.jp/dbget-bin/www_bget?KO:K13638 OMA HDIRTEG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HDIRTEG PDB 1Q08 http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q08 PDB 1Q09 http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q09 PDB 1Q0A http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q0A PDBsum 1Q08 http://www.ebi.ac.uk/pdbsum/1Q08 PDBsum 1Q09 http://www.ebi.ac.uk/pdbsum/1Q09 PDBsum 1Q0A http://www.ebi.ac.uk/pdbsum/1Q0A PRINTS PR00040 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00040 PROSITE PS00552 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00552 PROSITE PS50937 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50937 PSORT swissprot:ZNTR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ZNTR_ECOLI PSORT-B swissprot:ZNTR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ZNTR_ECOLI PSORT2 swissprot:ZNTR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ZNTR_ECOLI Pfam PF13411 http://pfam.xfam.org/family/PF13411 Phobius swissprot:ZNTR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ZNTR_ECOLI PhylomeDB P0ACS5 http://phylomedb.org/?seqid=P0ACS5 ProteinModelPortal P0ACS5 http://www.proteinmodelportal.org/query/uniprot/P0ACS5 PubMed 10048032 http://www.ncbi.nlm.nih.gov/pubmed/10048032 PubMed 12958362 http://www.ncbi.nlm.nih.gov/pubmed/12958362 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8063098 http://www.ncbi.nlm.nih.gov/pubmed/8063098 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417751 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417751 RefSeq WP_000285607 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000285607 SMART SM00422 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00422 SMR P0ACS5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACS5 STRING 511145.b3292 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3292&targetmode=cogs STRING COG0789 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0789&targetmode=cogs SUPFAM SSF46955 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46955 TIGRFAMs TIGR02043 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02043 UniProtKB ZNTR_ECOLI http://www.uniprot.org/uniprot/ZNTR_ECOLI UniProtKB-AC P0ACS5 http://www.uniprot.org/uniprot/P0ACS5 charge swissprot:ZNTR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ZNTR_ECOLI eggNOG COG0789 http://eggnogapi.embl.de/nog_data/html/tree/COG0789 eggNOG ENOG4105W1Y http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105W1Y epestfind swissprot:ZNTR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ZNTR_ECOLI garnier swissprot:ZNTR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ZNTR_ECOLI helixturnhelix swissprot:ZNTR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ZNTR_ECOLI hmoment swissprot:ZNTR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ZNTR_ECOLI iep swissprot:ZNTR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ZNTR_ECOLI inforesidue swissprot:ZNTR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ZNTR_ECOLI octanol swissprot:ZNTR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ZNTR_ECOLI pepcoil swissprot:ZNTR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ZNTR_ECOLI pepdigest swissprot:ZNTR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ZNTR_ECOLI pepinfo swissprot:ZNTR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ZNTR_ECOLI pepnet swissprot:ZNTR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ZNTR_ECOLI pepstats swissprot:ZNTR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ZNTR_ECOLI pepwheel swissprot:ZNTR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ZNTR_ECOLI pepwindow swissprot:ZNTR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ZNTR_ECOLI sigcleave swissprot:ZNTR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ZNTR_ECOLI ## Database ID URL or Descriptions # EcoGene EG40003 insC1 # FUNCTION INSC1_ECOLI Involved in the transposition of the insertion sequence IS2. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 1.10.10.60 -; 1. # InterPro IPR002514 Transposase_8 # InterPro IPR009057 Homeodomain-like # Organism INSC1_ECOLI Escherichia coli (strain K12) # PIR B65240 B65240 # Pfam PF01527 HTH_Tnp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSC1_ECOLI Transposase InsC for insertion element IS2A # RefSeq NP_414894 NC_000913.3 # RefSeq NP_415921 NC_000913.3 # RefSeq NP_417338 NC_000913.3 # RefSeq NP_417516 NC_000913.3 # RefSeq NP_418692 NC_000913.3 # RefSeq WP_000567766 NZ_LN832404.1 # RefSeq YP_026163 NC_000913.3 # SEQUENCE CAUTION Sequence=AAB18084.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAE76141.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the transposase 8 family. {ECO 0000305}. # SUPFAM SSF46689 SSF46689 # eggNOG COG2963 LUCA # eggNOG ENOG4108ZQS Bacteria BLAST swissprot:INSC1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSC1_ECOLI BioCyc EcoCyc:G6212-MONOMER http://biocyc.org/getid?id=EcoCyc:G6212-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB4751 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4751 EcoGene EG40003 http://www.ecogene.org/geneInfo.php?eg_id=EG40003 EnsemblBacteria AAC73463 http://www.ensemblgenomes.org/id/AAC73463 EnsemblBacteria AAC73463 http://www.ensemblgenomes.org/id/AAC73463 EnsemblBacteria BAE76141 http://www.ensemblgenomes.org/id/BAE76141 EnsemblBacteria BAE76141 http://www.ensemblgenomes.org/id/BAE76141 EnsemblBacteria BAE76141 http://www.ensemblgenomes.org/id/BAE76141 EnsemblBacteria b0360 http://www.ensemblgenomes.org/id/b0360 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 GeneID 945025 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945025 GeneID 945967 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945967 GeneID 946455 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946455 GeneID 947347 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947347 GeneID 947520 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947520 GeneID 948781 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948781 InParanoid P0CF40 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CF40 InterPro IPR002514 http://www.ebi.ac.uk/interpro/entry/IPR002514 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 KEGG_Gene ecj:JW0351 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0351 KEGG_Gene eco:b0360 http://www.genome.jp/dbget-bin/www_bget?eco:b0360 KEGG_Gene eco:b1403 http://www.genome.jp/dbget-bin/www_bget?eco:b1403 KEGG_Gene eco:b1997 http://www.genome.jp/dbget-bin/www_bget?eco:b1997 KEGG_Gene eco:b2861 http://www.genome.jp/dbget-bin/www_bget?eco:b2861 KEGG_Gene eco:b3044 http://www.genome.jp/dbget-bin/www_bget?eco:b3044 KEGG_Gene eco:b4272 http://www.genome.jp/dbget-bin/www_bget?eco:b4272 PSORT swissprot:INSC1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSC1_ECOLI PSORT-B swissprot:INSC1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSC1_ECOLI PSORT2 swissprot:INSC1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSC1_ECOLI Pfam PF01527 http://pfam.xfam.org/family/PF01527 Phobius swissprot:INSC1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSC1_ECOLI PhylomeDB P0CF40 http://phylomedb.org/?seqid=P0CF40 ProteinModelPortal P0CF40 http://www.proteinmodelportal.org/query/uniprot/P0CF40 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414894 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414894 RefSeq NP_415921 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415921 RefSeq NP_417338 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417338 RefSeq NP_417516 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417516 RefSeq NP_418692 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418692 RefSeq WP_000567766 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000567766 RefSeq YP_026163 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026163 STRING 511145.b4272 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4272&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 UniProtKB INSC1_ECOLI http://www.uniprot.org/uniprot/INSC1_ECOLI UniProtKB-AC P0CF40 http://www.uniprot.org/uniprot/P0CF40 charge swissprot:INSC1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSC1_ECOLI eggNOG COG2963 http://eggnogapi.embl.de/nog_data/html/tree/COG2963 eggNOG ENOG4108ZQS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZQS epestfind swissprot:INSC1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSC1_ECOLI garnier swissprot:INSC1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSC1_ECOLI helixturnhelix swissprot:INSC1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSC1_ECOLI hmoment swissprot:INSC1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSC1_ECOLI iep swissprot:INSC1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSC1_ECOLI inforesidue swissprot:INSC1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSC1_ECOLI octanol swissprot:INSC1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSC1_ECOLI pepcoil swissprot:INSC1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSC1_ECOLI pepdigest swissprot:INSC1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSC1_ECOLI pepinfo swissprot:INSC1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSC1_ECOLI pepnet swissprot:INSC1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSC1_ECOLI pepstats swissprot:INSC1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSC1_ECOLI pepwheel swissprot:INSC1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSC1_ECOLI pepwindow swissprot:INSC1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSC1_ECOLI sigcleave swissprot:INSC1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSC1_ECOLI ## Database ID URL or Descriptions # AltName S-methylmethionine homocysteine methyltransferase # BIOPHYSICOCHEMICAL PROPERTIES MMUM_ECOLI Kinetic parameters KM=0.045 mM for L-homocysteine {ECO 0000269|PubMed 10026151}; KM=0.59 mM for L-selenocysteine {ECO 0000269|PubMed 10026151}; KM=0.043 mM for DL-selenohomocysteine {ECO 0000269|PubMed 10026151}; # BRENDA 2.1.1.10 2026 # BRENDA 2.1.1.280 2026 # BioGrid 4259777 8 # CATALYTIC ACTIVITY MMUM_ECOLI S-methyl-L-methionine + L-homocysteine = 2 L- methionine. # COFACTOR MMUM_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000255|PROSITE-ProRule PRU00333}; # EcoGene EG13343 mmuM # FUNCTION MMUM_ECOLI Catalyzes methyl transfer from S-methylmethionine or S- adenosylmethionine (less efficient) to homocysteine, selenohomocysteine and less efficiently selenocysteine. {ECO 0000269|PubMed 9882684}. # GO_function GO:0008898 S-adenosylmethionine-homocysteine S-methyltransferase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0009086 methionine biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0033477 S-methylmethionine metabolic process; IMP:EcoCyc. # GOslim_function GO:0008168 methyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.20.20.330 -; 1. # IntAct Q47690 5 # InterPro IPR003726 HCY_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00270 Cysteine and methionine metabolism # Organism MMUM_ECOLI Escherichia coli (strain K12) # PATRIC 32115641 VBIEscCol129921_0264 # PDB 5DML X-ray; 2.45 A; A=1-310 # PDB 5DMM X-ray; 1.78 A; A=1-310 # PDB 5DMN X-ray; 2.89 A; A/B=1-310 # PIR E64751 E64751 # PROSITE PS50970 HCY # Pfam PF02574 S-methyl_trans # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MMUM_ECOLI Homocysteine S-methyltransferase # RefSeq NP_414795 NC_000913.3 # RefSeq WP_000081352 NZ_LN832404.1 # RefSeq YP_001816637 NC_010558.1 # SIMILARITY Contains 1 Hcy-binding domain. {ECO:0000255|PROSITE- ProRule PRU00333}. # SUBUNIT Monomer. {ECO:0000269|PubMed 10026151}. # SUPFAM SSF82282 SSF82282 # eggNOG COG2040 LUCA # eggNOG ENOG4107QK5 Bacteria BLAST swissprot:MMUM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MMUM_ECOLI BioCyc ECOL316407:JW0253-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0253-MONOMER BioCyc EcoCyc:MMUM-MONOMER http://biocyc.org/getid?id=EcoCyc:MMUM-MONOMER BioCyc MetaCyc:MMUM-MONOMER http://biocyc.org/getid?id=MetaCyc:MMUM-MONOMER COG COG2040 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2040 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.274.9.5407 http://dx.doi.org/10.1074/jbc.274.9.5407 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.1.10 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.10 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 ENZYME 2.1.1.10 http://enzyme.expasy.org/EC/2.1.1.10 EcoGene EG13343 http://www.ecogene.org/geneInfo.php?eg_id=EG13343 EnsemblBacteria AAC73364 http://www.ensemblgenomes.org/id/AAC73364 EnsemblBacteria AAC73364 http://www.ensemblgenomes.org/id/AAC73364 EnsemblBacteria BAA77929 http://www.ensemblgenomes.org/id/BAA77929 EnsemblBacteria BAA77929 http://www.ensemblgenomes.org/id/BAA77929 EnsemblBacteria BAA77929 http://www.ensemblgenomes.org/id/BAA77929 EnsemblBacteria b0261 http://www.ensemblgenomes.org/id/b0261 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008898 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008898 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0009086 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009086 GO_process GO:0033477 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033477 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.20.20.330 http://www.cathdb.info/version/latest/superfamily/3.20.20.330 GeneID 6275998 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6275998 GeneID 946143 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946143 HOGENOM HOG000265278 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000265278&db=HOGENOM6 InParanoid Q47690 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q47690 IntAct Q47690 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q47690* IntEnz 2.1.1.10 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.10 InterPro IPR003726 http://www.ebi.ac.uk/interpro/entry/IPR003726 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0253 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0253 KEGG_Gene eco:b0261 http://www.genome.jp/dbget-bin/www_bget?eco:b0261 KEGG_Orthology KO:K00547 http://www.genome.jp/dbget-bin/www_bget?KO:K00547 KEGG_Pathway ko00270 http://www.genome.jp/kegg-bin/show_pathway?ko00270 KEGG_Reaction rn:R00650 http://www.genome.jp/dbget-bin/www_bget?rn:R00650 OMA CCRTTPK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CCRTTPK PDB 5DML http://www.ebi.ac.uk/pdbe-srv/view/entry/5DML PDB 5DMM http://www.ebi.ac.uk/pdbe-srv/view/entry/5DMM PDB 5DMN http://www.ebi.ac.uk/pdbe-srv/view/entry/5DMN PDBsum 5DML http://www.ebi.ac.uk/pdbsum/5DML PDBsum 5DMM http://www.ebi.ac.uk/pdbsum/5DMM PDBsum 5DMN http://www.ebi.ac.uk/pdbsum/5DMN PROSITE PS50970 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50970 PSORT swissprot:MMUM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MMUM_ECOLI PSORT-B swissprot:MMUM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MMUM_ECOLI PSORT2 swissprot:MMUM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MMUM_ECOLI Pfam PF02574 http://pfam.xfam.org/family/PF02574 Phobius swissprot:MMUM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MMUM_ECOLI PhylomeDB Q47690 http://phylomedb.org/?seqid=Q47690 ProteinModelPortal Q47690 http://www.proteinmodelportal.org/query/uniprot/Q47690 PubMed 10026151 http://www.ncbi.nlm.nih.gov/pubmed/10026151 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9882684 http://www.ncbi.nlm.nih.gov/pubmed/9882684 RefSeq NP_414795 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414795 RefSeq WP_000081352 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000081352 RefSeq YP_001816637 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001816637 SMR Q47690 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q47690 STRING 511145.b0261 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0261&targetmode=cogs STRING COG2040 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2040&targetmode=cogs SUPFAM SSF82282 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF82282 UniProtKB MMUM_ECOLI http://www.uniprot.org/uniprot/MMUM_ECOLI UniProtKB-AC Q47690 http://www.uniprot.org/uniprot/Q47690 charge swissprot:MMUM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MMUM_ECOLI eggNOG COG2040 http://eggnogapi.embl.de/nog_data/html/tree/COG2040 eggNOG ENOG4107QK5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QK5 epestfind swissprot:MMUM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MMUM_ECOLI garnier swissprot:MMUM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MMUM_ECOLI helixturnhelix swissprot:MMUM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MMUM_ECOLI hmoment swissprot:MMUM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MMUM_ECOLI iep swissprot:MMUM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MMUM_ECOLI inforesidue swissprot:MMUM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MMUM_ECOLI octanol swissprot:MMUM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MMUM_ECOLI pepcoil swissprot:MMUM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MMUM_ECOLI pepdigest swissprot:MMUM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MMUM_ECOLI pepinfo swissprot:MMUM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MMUM_ECOLI pepnet swissprot:MMUM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MMUM_ECOLI pepstats swissprot:MMUM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MMUM_ECOLI pepwheel swissprot:MMUM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MMUM_ECOLI pepwindow swissprot:MMUM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MMUM_ECOLI sigcleave swissprot:MMUM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MMUM_ECOLI ## Database ID URL or Descriptions # BioGrid 4261344 4 # EcoGene EG12486 yjfK # InterPro IPR019621 DUF2491 # Organism YJFK_ECOLI Escherichia coli (strain K12) # PATRIC 32123941 VBIEscCol129921_4315 # PIR S56408 S56408 # Pfam PF10679 DUF2491 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJFK_ECOLI Uncharacterized protein YjfK # RefSeq NP_418604 NC_000913.3 # RefSeq WP_000012550 NZ_LN832404.1 # eggNOG ENOG4107VNS Bacteria # eggNOG ENOG410ZH1C LUCA BLAST swissprot:YJFK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJFK_ECOLI BioCyc ECOL316407:JW4141-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4141-MONOMER BioCyc EcoCyc:G7848-MONOMER http://biocyc.org/getid?id=EcoCyc:G7848-MONOMER DIP DIP-12589N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12589N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2379 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2379 EcoGene EG12486 http://www.ecogene.org/geneInfo.php?eg_id=EG12486 EnsemblBacteria AAC77140 http://www.ensemblgenomes.org/id/AAC77140 EnsemblBacteria AAC77140 http://www.ensemblgenomes.org/id/AAC77140 EnsemblBacteria BAE78184 http://www.ensemblgenomes.org/id/BAE78184 EnsemblBacteria BAE78184 http://www.ensemblgenomes.org/id/BAE78184 EnsemblBacteria BAE78184 http://www.ensemblgenomes.org/id/BAE78184 EnsemblBacteria b4183 http://www.ensemblgenomes.org/id/b4183 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 948702 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948702 HOGENOM HOG000127342 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000127342&db=HOGENOM6 IntAct P39293 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39293* InterPro IPR019621 http://www.ebi.ac.uk/interpro/entry/IPR019621 KEGG_Gene ecj:JW4141 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4141 KEGG_Gene eco:b4183 http://www.genome.jp/dbget-bin/www_bget?eco:b4183 MINT MINT-1246901 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1246901 OMA ENHITDV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ENHITDV PSORT swissprot:YJFK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJFK_ECOLI PSORT-B swissprot:YJFK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJFK_ECOLI PSORT2 swissprot:YJFK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJFK_ECOLI Pfam PF10679 http://pfam.xfam.org/family/PF10679 Phobius swissprot:YJFK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJFK_ECOLI ProteinModelPortal P39293 http://www.proteinmodelportal.org/query/uniprot/P39293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418604 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418604 RefSeq WP_000012550 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000012550 STRING 511145.b4183 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4183&targetmode=cogs UniProtKB YJFK_ECOLI http://www.uniprot.org/uniprot/YJFK_ECOLI UniProtKB-AC P39293 http://www.uniprot.org/uniprot/P39293 charge swissprot:YJFK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJFK_ECOLI eggNOG ENOG4107VNS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107VNS eggNOG ENOG410ZH1C http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZH1C epestfind swissprot:YJFK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJFK_ECOLI garnier swissprot:YJFK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJFK_ECOLI helixturnhelix swissprot:YJFK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJFK_ECOLI hmoment swissprot:YJFK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJFK_ECOLI iep swissprot:YJFK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJFK_ECOLI inforesidue swissprot:YJFK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJFK_ECOLI octanol swissprot:YJFK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJFK_ECOLI pepcoil swissprot:YJFK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJFK_ECOLI pepdigest swissprot:YJFK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJFK_ECOLI pepinfo swissprot:YJFK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJFK_ECOLI pepnet swissprot:YJFK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJFK_ECOLI pepstats swissprot:YJFK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJFK_ECOLI pepwheel swissprot:YJFK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJFK_ECOLI pepwindow swissprot:YJFK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJFK_ECOLI sigcleave swissprot:YJFK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJFK_ECOLI ## Database ID URL or Descriptions # AltName GSPF_ECOLI General secretion pathway protein F # AltName GSPF_ECOLI Protein transport protein HofF # BioGrid 4262168 98 # EcoGene EG12885 gspF # FUNCTION GSPF_ECOLI Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. {ECO 0000305}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0015627 type II protein secretion system complex; IEA:InterPro. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0008565 protein transporter activity; IEA:InterPro. # GO_process GO:0015628 protein secretion by the type II secretion system; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0008565 protein transporter activity # GOslim_process GO:0055085 transmembrane transport # INDUCTION Silenced by the DNA-binding protein H-NS under standard growth conditions. {ECO:0000269|PubMed 11118204}. # InterPro IPR001992 Type_2_secretion_system_CS # InterPro IPR003004 GspF/PilC # InterPro IPR011850 GspF # InterPro IPR018076 T2SS_F # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02044 M00331 Type II general secretion system # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko03070 Bacterial secretion system # MISCELLANEOUS GSPF_ECOLI Part of a cryptic operon that encodes proteins involved in type II secretion machinery in other organisms, but is not expressed in strain K12. # Organism GSPF_ECOLI Escherichia coli (strain K12) # PATRIC 32122086 VBIEscCol129921_3420 # PIR B65126 B65126 # PRINTS PR00812 BCTERIALGSPF # PROSITE PS00874 T2SP_F # Pfam PF00482 T2SSF; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GSPF_ECOLI Putative type II secretion system protein F # RefSeq NP_417786 NC_000913.3 # RefSeq WP_001109573 NZ_LN832404.1 # SIMILARITY Belongs to the GSP F family. {ECO 0000305}. # SUBCELLULAR LOCATION GSPF_ECOLI Cell inner membrane; Multi-pass membrane protein. # TIGRFAMs TIGR02120 GspF # eggNOG COG1459 LUCA # eggNOG ENOG4105D7Q Bacteria BLAST swissprot:GSPF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GSPF_ECOLI BioCyc ECOL316407:JW3289-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3289-MONOMER BioCyc EcoCyc:G7705-MONOMER http://biocyc.org/getid?id=EcoCyc:G7705-MONOMER BioCyc MetaCyc:G7705-MONOMER http://biocyc.org/getid?id=MetaCyc:G7705-MONOMER COG COG1459 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1459 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/emboj/19.24.6697 http://dx.doi.org/10.1093/emboj/19.24.6697 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL U20786 http://www.ebi.ac.uk/ena/data/view/U20786 EchoBASE EB2722 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2722 EcoGene EG12885 http://www.ecogene.org/geneInfo.php?eg_id=EG12885 EnsemblBacteria AAC76352 http://www.ensemblgenomes.org/id/AAC76352 EnsemblBacteria AAC76352 http://www.ensemblgenomes.org/id/AAC76352 EnsemblBacteria BAE77964 http://www.ensemblgenomes.org/id/BAE77964 EnsemblBacteria BAE77964 http://www.ensemblgenomes.org/id/BAE77964 EnsemblBacteria BAE77964 http://www.ensemblgenomes.org/id/BAE77964 EnsemblBacteria b3327 http://www.ensemblgenomes.org/id/b3327 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0015627 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015627 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GO_process GO:0015628 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015628 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 947829 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947829 HOGENOM HOG000253739 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000253739&db=HOGENOM6 InParanoid P41441 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P41441 InterPro IPR001992 http://www.ebi.ac.uk/interpro/entry/IPR001992 InterPro IPR003004 http://www.ebi.ac.uk/interpro/entry/IPR003004 InterPro IPR011850 http://www.ebi.ac.uk/interpro/entry/IPR011850 InterPro IPR018076 http://www.ebi.ac.uk/interpro/entry/IPR018076 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW3289 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3289 KEGG_Gene eco:b3327 http://www.genome.jp/dbget-bin/www_bget?eco:b3327 KEGG_Orthology KO:K02455 http://www.genome.jp/dbget-bin/www_bget?KO:K02455 KEGG_Pathway ko03070 http://www.genome.jp/kegg-bin/show_pathway?ko03070 OMA FEPLMIL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FEPLMIL PRINTS PR00812 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00812 PROSITE PS00874 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00874 PSORT swissprot:GSPF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GSPF_ECOLI PSORT-B swissprot:GSPF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GSPF_ECOLI PSORT2 swissprot:GSPF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GSPF_ECOLI Pfam PF00482 http://pfam.xfam.org/family/PF00482 Phobius swissprot:GSPF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GSPF_ECOLI PhylomeDB P41441 http://phylomedb.org/?seqid=P41441 ProteinModelPortal P41441 http://www.proteinmodelportal.org/query/uniprot/P41441 PubMed 11118204 http://www.ncbi.nlm.nih.gov/pubmed/11118204 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7896718 http://www.ncbi.nlm.nih.gov/pubmed/7896718 PubMed 8655552 http://www.ncbi.nlm.nih.gov/pubmed/8655552 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417786 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417786 RefSeq WP_001109573 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001109573 SMR P41441 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P41441 STRING 511145.b3327 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3327&targetmode=cogs STRING COG1459 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1459&targetmode=cogs TIGRFAMs TIGR02120 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02120 UniProtKB GSPF_ECOLI http://www.uniprot.org/uniprot/GSPF_ECOLI UniProtKB-AC P41441 http://www.uniprot.org/uniprot/P41441 charge swissprot:GSPF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GSPF_ECOLI eggNOG COG1459 http://eggnogapi.embl.de/nog_data/html/tree/COG1459 eggNOG ENOG4105D7Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D7Q epestfind swissprot:GSPF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GSPF_ECOLI garnier swissprot:GSPF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GSPF_ECOLI helixturnhelix swissprot:GSPF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GSPF_ECOLI hmoment swissprot:GSPF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GSPF_ECOLI iep swissprot:GSPF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GSPF_ECOLI inforesidue swissprot:GSPF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GSPF_ECOLI octanol swissprot:GSPF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GSPF_ECOLI pepcoil swissprot:GSPF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GSPF_ECOLI pepdigest swissprot:GSPF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GSPF_ECOLI pepinfo swissprot:GSPF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GSPF_ECOLI pepnet swissprot:GSPF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GSPF_ECOLI pepstats swissprot:GSPF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GSPF_ECOLI pepwheel swissprot:GSPF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GSPF_ECOLI pepwindow swissprot:GSPF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GSPF_ECOLI sigcleave swissprot:GSPF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GSPF_ECOLI ## Database ID URL or Descriptions # AltName Ribosomal back-translocase LepA {ECO:0000255|HAMAP-Rule MF_00071} # BioGrid 4260596 215 # CATALYTIC ACTIVITY LEPA_ECOLI GTP + H(2)O = GDP + phosphate. {ECO 0000255|HAMAP-Rule MF_00071, ECO 0000269|PubMed 20045415}. # EcoGene EG10529 lepA # FUNCTION LEPA_ECOLI Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner. {ECO 0000255|HAMAP- Rule MF_00071, ECO 0000269|PubMed 17110332, ECO 0000269|PubMed 20045415}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_function GO:0003746 translation elongation factor activity; IDA:EcoCyc. # GO_function GO:0003924 GTPase activity; IDA:EcoCyc. # GO_function GO:0005525 GTP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0043022 ribosome binding; IEA:UniProtKB-HAMAP. # GO_function GO:0043023 ribosomal large subunit binding; IDA:EcoCyc. # GO_function GO:0043024 ribosomal small subunit binding; IDA:EcoCyc. # GO_process GO:0006414 translational elongation; IDA:EcoCyc. # GO_process GO:0009268 response to pH; IMP:EcoCyc. # GO_process GO:0009409 response to cold; IMP:EcoCyc. # GO_process GO:0009651 response to salt stress; IMP:EcoCyc. # GO_process GO:0045727 positive regulation of translation; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003924 GTPase activity # GOslim_function GO:0008135 translation factor activity, RNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.30.70.240 -; 1. # Gene3D 3.40.50.300 -; 1. # HAMAP MF_00071 LepA # IntAct P60785 22 # InterPro IPR000640 EFG_V # InterPro IPR000795 TF_GTP-bd_dom # InterPro IPR004161 EFTu-like_2 # InterPro IPR005225 Small_GTP-bd_dom # InterPro IPR006297 EF-4 # InterPro IPR009022 EFG_III-V # InterPro IPR013842 LepA_GTP-bd_C # InterPro IPR027417 P-loop_NTPase # InterPro IPR031157 G_TR_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko05134 Legionellosis # Organism LEPA_ECOLI Escherichia coli (strain K12) # PATRIC 32120537 VBIEscCol129921_2671 # PDB 3CB4 X-ray; 2.80 A; A/B/C/D/E/F=1-599 # PDB 3DEG EM; -; C=1-545 # PDB 3JCD EM; 3.70 A; x=1-599 # PDB 3JCE EM; 3.20 A; x=1-599 # PIR H65034 BVECLA # PRINTS PR00315 ELONGATNFCT # PROSITE PS00301 G_TR_1 # PROSITE PS51722 G_TR_2 # Pfam PF00679 EFG_C # Pfam PF03144 GTP_EFTU_D2 # Pfam PF06421 LepA_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Elongation factor 4 {ECO:0000255|HAMAP-Rule MF_00071} # RefSeq NP_417064 NC_000913.3 # RefSeq WP_000790168 NZ_LN832404.1 # SIMILARITY Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily. {ECO:0000255|HAMAP-Rule MF_00071}. # SIMILARITY Contains 1 tr-type G (guanine nucleotide-binding) domain. {ECO 0000305}. # SUBCELLULAR LOCATION LEPA_ECOLI Cell inner membrane {ECO 0000305|PubMed 2999765}; Peripheral membrane protein {ECO 0000305|PubMed 2999765}; Cytoplasmic side {ECO 0000305|PubMed 2999765}. # SUPFAM SSF52540 SSF52540 # SUPFAM SSF54980 SSF54980; 2 # TIGRFAMs TIGR00231 small_GTP # TIGRFAMs TIGR01393 lepA # eggNOG COG0481 LUCA # eggNOG ENOG4105C4S Bacteria BLAST swissprot:LEPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LEPA_ECOLI BioCyc ECOL316407:JW2553-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2553-MONOMER BioCyc EcoCyc:EG10529-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10529-MONOMER BioCyc MetaCyc:EG10529-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10529-MONOMER COG COG0481 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0481 DIP DIP-29868N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-29868N DOI 10.1016/j.cell.2006.09.037 http://dx.doi.org/10.1016/j.cell.2006.09.037 DOI 10.1016/j.jmb.2009.12.043 http://dx.doi.org/10.1016/j.jmb.2009.12.043 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsmb.1469 http://dx.doi.org/10.1038/nsmb.1469 DOI 10.1073/pnas.0801308105 http://dx.doi.org/10.1073/pnas.0801308105 DOI 10.1073/pnas.82.22.7500 http://dx.doi.org/10.1073/pnas.82.22.7500 DOI 10.1111/j.1432-1033.1987.tb13671.x http://dx.doi.org/10.1111/j.1432-1033.1987.tb13671.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.5.n1 {ECO:0000255|HAMAP-Rule:MF_00071} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.5.n1 {ECO:0000255|HAMAP-Rule:MF_00071} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D64044 http://www.ebi.ac.uk/ena/data/view/D64044 EMBL K00426 http://www.ebi.ac.uk/ena/data/view/K00426 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.6.5.n1 {ECO:0000255|HAMAP-Rule:MF_00071} http://enzyme.expasy.org/EC/3.6.5.n1 {ECO:0000255|HAMAP-Rule:MF_00071} EchoBASE EB0524 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0524 EcoGene EG10529 http://www.ecogene.org/geneInfo.php?eg_id=EG10529 EnsemblBacteria AAC75622 http://www.ensemblgenomes.org/id/AAC75622 EnsemblBacteria AAC75622 http://www.ensemblgenomes.org/id/AAC75622 EnsemblBacteria BAE76745 http://www.ensemblgenomes.org/id/BAE76745 EnsemblBacteria BAE76745 http://www.ensemblgenomes.org/id/BAE76745 EnsemblBacteria BAE76745 http://www.ensemblgenomes.org/id/BAE76745 EnsemblBacteria b2569 http://www.ensemblgenomes.org/id/b2569 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0003746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003746 GO_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_function GO:0043022 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043022 GO_function GO:0043023 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043023 GO_function GO:0043024 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043024 GO_process GO:0006414 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006414 GO_process GO:0009268 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009268 GO_process GO:0009409 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009409 GO_process GO:0009651 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009651 GO_process GO:0045727 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045727 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GOslim_function GO:0008135 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008135 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.30.70.240 http://www.cathdb.info/version/latest/superfamily/3.30.70.240 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947051 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947051 HAMAP MF_00071 http://hamap.expasy.org/unirule/MF_00071 HOGENOM HOG000020624 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000020624&db=HOGENOM6 InParanoid P60785 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P60785 IntAct P60785 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P60785* IntEnz 3.6.5.n1 {ECO:0000255|HAMAP-Rule:MF_00071} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.5.n1 {ECO:0000255|HAMAP-Rule:MF_00071} InterPro IPR000640 http://www.ebi.ac.uk/interpro/entry/IPR000640 InterPro IPR000795 http://www.ebi.ac.uk/interpro/entry/IPR000795 InterPro IPR004161 http://www.ebi.ac.uk/interpro/entry/IPR004161 InterPro IPR005225 http://www.ebi.ac.uk/interpro/entry/IPR005225 InterPro IPR006297 http://www.ebi.ac.uk/interpro/entry/IPR006297 InterPro IPR009022 http://www.ebi.ac.uk/interpro/entry/IPR009022 InterPro IPR013842 http://www.ebi.ac.uk/interpro/entry/IPR013842 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR031157 http://www.ebi.ac.uk/interpro/entry/IPR031157 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW2553 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2553 KEGG_Gene eco:b2569 http://www.genome.jp/dbget-bin/www_bget?eco:b2569 KEGG_Orthology KO:K03596 http://www.genome.jp/dbget-bin/www_bget?KO:K03596 KEGG_Pathway ko05134 http://www.genome.jp/kegg-bin/show_pathway?ko05134 MINT MINT-1225739 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1225739 OMA FAGIYPV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FAGIYPV PDB 3CB4 http://www.ebi.ac.uk/pdbe-srv/view/entry/3CB4 PDB 3DEG http://www.ebi.ac.uk/pdbe-srv/view/entry/3DEG PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDBsum 3CB4 http://www.ebi.ac.uk/pdbsum/3CB4 PDBsum 3DEG http://www.ebi.ac.uk/pdbsum/3DEG PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PRINTS PR00315 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00315 PROSITE PS00301 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00301 PROSITE PS51722 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51722 PSORT swissprot:LEPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LEPA_ECOLI PSORT-B swissprot:LEPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LEPA_ECOLI PSORT2 swissprot:LEPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LEPA_ECOLI Pfam PF00679 http://pfam.xfam.org/family/PF00679 Pfam PF03144 http://pfam.xfam.org/family/PF03144 Pfam PF06421 http://pfam.xfam.org/family/PF06421 Phobius swissprot:LEPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LEPA_ECOLI PhylomeDB P60785 http://phylomedb.org/?seqid=P60785 ProteinModelPortal P60785 http://www.proteinmodelportal.org/query/uniprot/P60785 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17110332 http://www.ncbi.nlm.nih.gov/pubmed/17110332 PubMed 18362332 http://www.ncbi.nlm.nih.gov/pubmed/18362332 PubMed 19172743 http://www.ncbi.nlm.nih.gov/pubmed/19172743 PubMed 20045415 http://www.ncbi.nlm.nih.gov/pubmed/20045415 PubMed 2826164 http://www.ncbi.nlm.nih.gov/pubmed/2826164 PubMed 2987248 http://www.ncbi.nlm.nih.gov/pubmed/2987248 PubMed 2999765 http://www.ncbi.nlm.nih.gov/pubmed/2999765 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417064 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417064 RefSeq WP_000790168 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000790168 SMR P60785 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P60785 STRING 511145.b2569 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2569&targetmode=cogs STRING COG0481 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0481&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SUPFAM SSF54980 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54980 TIGRFAMs TIGR00231 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00231 TIGRFAMs TIGR01393 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01393 UniProtKB LEPA_ECOLI http://www.uniprot.org/uniprot/LEPA_ECOLI UniProtKB-AC P60785 http://www.uniprot.org/uniprot/P60785 charge swissprot:LEPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LEPA_ECOLI eggNOG COG0481 http://eggnogapi.embl.de/nog_data/html/tree/COG0481 eggNOG ENOG4105C4S http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C4S epestfind swissprot:LEPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LEPA_ECOLI garnier swissprot:LEPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LEPA_ECOLI helixturnhelix swissprot:LEPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LEPA_ECOLI hmoment swissprot:LEPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LEPA_ECOLI iep swissprot:LEPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LEPA_ECOLI inforesidue swissprot:LEPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LEPA_ECOLI octanol swissprot:LEPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LEPA_ECOLI pepcoil swissprot:LEPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LEPA_ECOLI pepdigest swissprot:LEPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LEPA_ECOLI pepinfo swissprot:LEPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LEPA_ECOLI pepnet swissprot:LEPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LEPA_ECOLI pepstats swissprot:LEPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LEPA_ECOLI pepwheel swissprot:LEPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LEPA_ECOLI pepwindow swissprot:LEPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LEPA_ECOLI sigcleave swissprot:LEPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LEPA_ECOLI ## Database ID URL or Descriptions # EcoGene EG12757 tdcF # FUNCTION TDCF_ECOLI May be a post-translational regulator that controls the metabolic fate of L-threonine or the potentially toxic intermediate 2-ketobutyrate. # GO_function GO:0016787 hydrolase activity; IEA:UniProtKB-KW. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0006566 threonine metabolic process; IDA:UniProtKB. # GO_process GO:0070689 L-threonine catabolic process to propionate; IEA:UniProtKB-UniPathway. # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009056 catabolic process # Gene3D 3.30.1330.40 -; 1. # InterPro IPR006056 RidA # InterPro IPR006175 YjgF/YER057c/UK114 # InterPro IPR013813 Endoribo_LPSP/chorism_mut-like # InterPro IPR019897 RidA_CS # Organism TDCF_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11803 PTHR11803 # PATHWAY TDCF_ECOLI Amino-acid degradation; L-threonine degradation via propanoate pathway. # PATRIC 32121642 VBIEscCol129921_3207 # PDB 2UYJ X-ray; 2.35 A; A/B/C=1-129 # PDB 2UYK X-ray; 1.60 A; A/B/C=1-129 # PDB 2UYN X-ray; 1.60 A; A/B/C=1-129 # PDB 2UYP X-ray; 2.44 A; A/B/C=1-129 # PIR F65100 F65100 # PROSITE PS01094 UPF0076 # Pfam PF01042 Ribonuc_L-PSP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TDCF_ECOLI Putative reactive intermediate deaminase TdcF # RefSeq NP_417583 NC_000913.3 # RefSeq WP_000719990 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA57917.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the RutC family. {ECO 0000305}. # SUBUNIT Homotrimer. {ECO:0000269|PubMed 17506874}. # SUPFAM SSF55298 SSF55298 # TIGRFAMs TIGR00004 TIGR00004 # eggNOG COG0251 LUCA # eggNOG ENOG4105KME Bacteria BLAST swissprot:TDCF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TDCF_ECOLI BioCyc ECOL316407:JW5521-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5521-MONOMER BioCyc EcoCyc:G7626-MONOMER http://biocyc.org/getid?id=EcoCyc:G7626-MONOMER COG COG0251 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0251 DIP DIP-48213N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48213N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1998.00696.x http://dx.doi.org/10.1046/j.1365-2958.1998.00696.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1186/1472-6807-7-30 http://dx.doi.org/10.1186/1472-6807-7-30 EC_number EC:3.5.4.- http://www.genome.jp/dbget-bin/www_bget?EC:3.5.4.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 3.5.4.- http://enzyme.expasy.org/EC/3.5.4.- EchoBASE EB2611 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2611 EcoGene EG12757 http://www.ecogene.org/geneInfo.php?eg_id=EG12757 EnsemblBacteria AAC76148 http://www.ensemblgenomes.org/id/AAC76148 EnsemblBacteria AAC76148 http://www.ensemblgenomes.org/id/AAC76148 EnsemblBacteria BAE77161 http://www.ensemblgenomes.org/id/BAE77161 EnsemblBacteria BAE77161 http://www.ensemblgenomes.org/id/BAE77161 EnsemblBacteria BAE77161 http://www.ensemblgenomes.org/id/BAE77161 EnsemblBacteria b3113 http://www.ensemblgenomes.org/id/b3113 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016787 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016787 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0006566 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006566 GO_process GO:0070689 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070689 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 3.30.1330.40 http://www.cathdb.info/version/latest/superfamily/3.30.1330.40 GeneID 947624 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947624 HOGENOM HOG000267215 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267215&db=HOGENOM6 InParanoid P0AGL2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGL2 IntEnz 3.5.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.4 InterPro IPR006056 http://www.ebi.ac.uk/interpro/entry/IPR006056 InterPro IPR006175 http://www.ebi.ac.uk/interpro/entry/IPR006175 InterPro IPR013813 http://www.ebi.ac.uk/interpro/entry/IPR013813 InterPro IPR019897 http://www.ebi.ac.uk/interpro/entry/IPR019897 KEGG_Gene ecj:JW5521 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5521 KEGG_Gene eco:b3113 http://www.genome.jp/dbget-bin/www_bget?eco:b3113 KEGG_Orthology KO:K07567 http://www.genome.jp/dbget-bin/www_bget?KO:K07567 OMA GMVFTSG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GMVFTSG PANTHER PTHR11803 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11803 PDB 2UYJ http://www.ebi.ac.uk/pdbe-srv/view/entry/2UYJ PDB 2UYK http://www.ebi.ac.uk/pdbe-srv/view/entry/2UYK PDB 2UYN http://www.ebi.ac.uk/pdbe-srv/view/entry/2UYN PDB 2UYP http://www.ebi.ac.uk/pdbe-srv/view/entry/2UYP PDBsum 2UYJ http://www.ebi.ac.uk/pdbsum/2UYJ PDBsum 2UYK http://www.ebi.ac.uk/pdbsum/2UYK PDBsum 2UYN http://www.ebi.ac.uk/pdbsum/2UYN PDBsum 2UYP http://www.ebi.ac.uk/pdbsum/2UYP PROSITE PS01094 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01094 PSORT swissprot:TDCF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TDCF_ECOLI PSORT-B swissprot:TDCF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TDCF_ECOLI PSORT2 swissprot:TDCF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TDCF_ECOLI Pfam PF01042 http://pfam.xfam.org/family/PF01042 Phobius swissprot:TDCF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TDCF_ECOLI PhylomeDB P0AGL2 http://phylomedb.org/?seqid=P0AGL2 ProteinModelPortal P0AGL2 http://www.proteinmodelportal.org/query/uniprot/P0AGL2 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17506874 http://www.ncbi.nlm.nih.gov/pubmed/17506874 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9484901 http://www.ncbi.nlm.nih.gov/pubmed/9484901 RefSeq NP_417583 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417583 RefSeq WP_000719990 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000719990 SMR P0AGL2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AGL2 STRING 511145.b3113 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3113&targetmode=cogs STRING COG0251 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0251&targetmode=cogs SUPFAM SSF55298 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55298 TIGRFAMs TIGR00004 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00004 UniProtKB TDCF_ECOLI http://www.uniprot.org/uniprot/TDCF_ECOLI UniProtKB-AC P0AGL2 http://www.uniprot.org/uniprot/P0AGL2 charge swissprot:TDCF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TDCF_ECOLI eggNOG COG0251 http://eggnogapi.embl.de/nog_data/html/tree/COG0251 eggNOG ENOG4105KME http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KME epestfind swissprot:TDCF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TDCF_ECOLI garnier swissprot:TDCF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TDCF_ECOLI helixturnhelix swissprot:TDCF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TDCF_ECOLI hmoment swissprot:TDCF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TDCF_ECOLI iep swissprot:TDCF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TDCF_ECOLI inforesidue swissprot:TDCF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TDCF_ECOLI octanol swissprot:TDCF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TDCF_ECOLI pepcoil swissprot:TDCF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TDCF_ECOLI pepdigest swissprot:TDCF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TDCF_ECOLI pepinfo swissprot:TDCF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TDCF_ECOLI pepnet swissprot:TDCF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TDCF_ECOLI pepstats swissprot:TDCF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TDCF_ECOLI pepwheel swissprot:TDCF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TDCF_ECOLI pepwindow swissprot:TDCF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TDCF_ECOLI sigcleave swissprot:TDCF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TDCF_ECOLI ## Database ID URL or Descriptions # BioGrid 4261049 10 # EcoGene EG14387 yodD # GO_process GO:0044011 single-species biofilm formation on inanimate substrate; IMP:EcoCyc. # GO_process GO:0070301 cellular response to hydrogen peroxide; IMP:EcoCyc. # GO_process GO:0071468 cellular response to acidic pH; IMP:EcoCyc. # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # IntAct P64519 2 # InterPro IPR019669 Uncharacterised_YodD # Organism YODD_ECOLI Escherichia coli (strain K12) # PATRIC 32119235 VBIEscCol129921_2032 # Pfam PF10733 DUF2525 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YODD_ECOLI Uncharacterized protein YodD # RefSeq NP_416463 NC_000913.3 # RefSeq WP_000844800 NZ_LN832404.1 # eggNOG ENOG4105YX3 Bacteria # eggNOG ENOG411261I LUCA BLAST swissprot:YODD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YODD_ECOLI BioCyc ECOL316407:JW5317-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5317-MONOMER BioCyc EcoCyc:G7046-MONOMER http://biocyc.org/getid?id=EcoCyc:G7046-MONOMER DIP DIP-48227N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48227N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4130 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4130 EcoGene EG14387 http://www.ecogene.org/geneInfo.php?eg_id=EG14387 EnsemblBacteria AAC75020 http://www.ensemblgenomes.org/id/AAC75020 EnsemblBacteria AAC75020 http://www.ensemblgenomes.org/id/AAC75020 EnsemblBacteria BAE76554 http://www.ensemblgenomes.org/id/BAE76554 EnsemblBacteria BAE76554 http://www.ensemblgenomes.org/id/BAE76554 EnsemblBacteria BAE76554 http://www.ensemblgenomes.org/id/BAE76554 EnsemblBacteria b1953 http://www.ensemblgenomes.org/id/b1953 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0044011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044011 GO_process GO:0070301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070301 GO_process GO:0071468 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071468 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 946469 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946469 HOGENOM HOG000267963 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267963&db=HOGENOM6 IntAct P64519 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P64519* InterPro IPR019669 http://www.ebi.ac.uk/interpro/entry/IPR019669 KEGG_Gene ecj:JW5317 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5317 KEGG_Gene eco:b1953 http://www.genome.jp/dbget-bin/www_bget?eco:b1953 OMA GRGSHTW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GRGSHTW PSORT swissprot:YODD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YODD_ECOLI PSORT-B swissprot:YODD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YODD_ECOLI PSORT2 swissprot:YODD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YODD_ECOLI Pfam PF10733 http://pfam.xfam.org/family/PF10733 Phobius swissprot:YODD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YODD_ECOLI ProteinModelPortal P64519 http://www.proteinmodelportal.org/query/uniprot/P64519 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416463 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416463 RefSeq WP_000844800 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000844800 STRING 511145.b1953 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1953&targetmode=cogs UniProtKB YODD_ECOLI http://www.uniprot.org/uniprot/YODD_ECOLI UniProtKB-AC P64519 http://www.uniprot.org/uniprot/P64519 charge swissprot:YODD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YODD_ECOLI eggNOG ENOG4105YX3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105YX3 eggNOG ENOG411261I http://eggnogapi.embl.de/nog_data/html/tree/ENOG411261I epestfind swissprot:YODD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YODD_ECOLI garnier swissprot:YODD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YODD_ECOLI helixturnhelix swissprot:YODD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YODD_ECOLI hmoment swissprot:YODD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YODD_ECOLI iep swissprot:YODD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YODD_ECOLI inforesidue swissprot:YODD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YODD_ECOLI octanol swissprot:YODD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YODD_ECOLI pepcoil swissprot:YODD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YODD_ECOLI pepdigest swissprot:YODD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YODD_ECOLI pepinfo swissprot:YODD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YODD_ECOLI pepnet swissprot:YODD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YODD_ECOLI pepstats swissprot:YODD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YODD_ECOLI pepwheel swissprot:YODD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YODD_ECOLI pepwindow swissprot:YODD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YODD_ECOLI sigcleave swissprot:YODD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YODD_ECOLI ## Database ID URL or Descriptions # AltName TPX_ECOLI Scavengase P20 # BRENDA 1.11.1 2026 # BioGrid 4260151 128 # CDD cd03014 PRX_Atyp2cys # EcoGene EG12672 tpx # FUNCTION TPX_ECOLI Has antioxidant activity. Could remove peroxides or H(2)O(2) within the catalase- and peroxidase-deficient periplasmic space. # GO_component GO:0005737 cytoplasm; IDA:EcoCyc. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_function GO:0008379 thioredoxin peroxidase activity; IDA:EcoCyc. # GO_function GO:0032843 hydroperoxide reductase activity; IDA:EcoCyc. # GO_process GO:0034599 cellular response to oxidative stress; IMP:EcoCyc. # GO_process GO:0045454 cell redox homeostasis; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006950 response to stress # GOslim_process GO:0042592 homeostatic process # Gene3D 3.40.30.10 -; 1. # HAMAP MF_00269 Tpx # INTERACTION TPX_ECOLI P0A8E1 ycfP; NbExp=3; IntAct=EBI-369411, EBI-9129402; # IntAct P0A862 9 # InterPro IPR002065 Put_TPX # InterPro IPR012336 Thioredoxin-like_fold # InterPro IPR013740 Redoxin # InterPro IPR013766 Thioredoxin_domain # InterPro IPR018219 Tpx_CS # KEGG_Brite ko01000 Enzymes # Organism TPX_ECOLI Escherichia coli (strain K12) # PATRIC 32117922 VBIEscCol129921_1381 # PDB 1QXH X-ray; 2.20 A; A/B=2-168 # PDB 3HVS X-ray; 1.80 A; A/B=2-168 # PDB 3HVV X-ray; 1.75 A; A=2-168 # PDB 3HVX X-ray; 2.12 A; A/B/C/D=2-168 # PDB 3I43 X-ray; 2.80 A; A/B=2-168 # PDB 4AF2 X-ray; 1.97 A; A=1-168 # PIR JC5504 JC5504 # PROSITE PS01265 TPX # PROSITE PS51352 THIOREDOXIN_2 # PeroxiBase 6007 EcoTPx # Pfam PF08534 Redoxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TPX_ECOLI Thiol peroxidase # RefSeq NP_415840 NC_000913.3 # RefSeq WP_000084387 NZ_LN832404.1 # SIMILARITY Belongs to the AhpC/TSA family. Tpx subfamily. {ECO 0000305}. # SIMILARITY Contains 1 thioredoxin domain. {ECO 0000305}. # SUBCELLULAR LOCATION TPX_ECOLI Periplasm. # SUPFAM SSF52833 SSF52833 # eggNOG COG2077 LUCA # eggNOG ENOG4108V1J Bacteria BLAST swissprot:TPX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TPX_ECOLI BioCyc ECOL316407:JW1317-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1317-MONOMER BioCyc EcoCyc:G6660-MONOMER http://biocyc.org/getid?id=EcoCyc:G6660-MONOMER BioCyc MetaCyc:G6660-MONOMER http://biocyc.org/getid?id=MetaCyc:G6660-MONOMER COG COG2077 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2077 DIP DIP-31857N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31857N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.270.48.28635 http://dx.doi.org/10.1074/jbc.270.48.28635 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.11.1.- http://www.genome.jp/dbget-bin/www_bget?EC:1.11.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U33213 http://www.ebi.ac.uk/ena/data/view/U33213 EMBL U93212 http://www.ebi.ac.uk/ena/data/view/U93212 ENZYME 1.11.1.- http://enzyme.expasy.org/EC/1.11.1.- EchoBASE EB2538 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2538 EcoGene EG12672 http://www.ecogene.org/geneInfo.php?eg_id=EG12672 EnsemblBacteria AAC74406 http://www.ensemblgenomes.org/id/AAC74406 EnsemblBacteria AAC74406 http://www.ensemblgenomes.org/id/AAC74406 EnsemblBacteria BAA14906 http://www.ensemblgenomes.org/id/BAA14906 EnsemblBacteria BAA14906 http://www.ensemblgenomes.org/id/BAA14906 EnsemblBacteria BAA14906 http://www.ensemblgenomes.org/id/BAA14906 EnsemblBacteria b1324 http://www.ensemblgenomes.org/id/b1324 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0008379 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008379 GO_function GO:0032843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032843 GO_process GO:0034599 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034599 GO_process GO:0045454 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045454 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 Gene3D 3.40.30.10 http://www.cathdb.info/version/latest/superfamily/3.40.30.10 GeneID 945880 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945880 HAMAP MF_00269 http://hamap.expasy.org/unirule/MF_00269 HOGENOM HOG000022345 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000022345&db=HOGENOM6 InParanoid P0A862 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A862 IntAct P0A862 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A862* IntEnz 1.11.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.11.1 InterPro IPR002065 http://www.ebi.ac.uk/interpro/entry/IPR002065 InterPro IPR012336 http://www.ebi.ac.uk/interpro/entry/IPR012336 InterPro IPR013740 http://www.ebi.ac.uk/interpro/entry/IPR013740 InterPro IPR013766 http://www.ebi.ac.uk/interpro/entry/IPR013766 InterPro IPR018219 http://www.ebi.ac.uk/interpro/entry/IPR018219 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1317 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1317 KEGG_Gene eco:b1324 http://www.genome.jp/dbget-bin/www_bget?eco:b1324 KEGG_Orthology KO:K11065 http://www.genome.jp/dbget-bin/www_bget?KO:K11065 OMA KFNAQAN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KFNAQAN PDB 1QXH http://www.ebi.ac.uk/pdbe-srv/view/entry/1QXH PDB 3HVS http://www.ebi.ac.uk/pdbe-srv/view/entry/3HVS PDB 3HVV http://www.ebi.ac.uk/pdbe-srv/view/entry/3HVV PDB 3HVX http://www.ebi.ac.uk/pdbe-srv/view/entry/3HVX PDB 3I43 http://www.ebi.ac.uk/pdbe-srv/view/entry/3I43 PDB 4AF2 http://www.ebi.ac.uk/pdbe-srv/view/entry/4AF2 PDBsum 1QXH http://www.ebi.ac.uk/pdbsum/1QXH PDBsum 3HVS http://www.ebi.ac.uk/pdbsum/3HVS PDBsum 3HVV http://www.ebi.ac.uk/pdbsum/3HVV PDBsum 3HVX http://www.ebi.ac.uk/pdbsum/3HVX PDBsum 3I43 http://www.ebi.ac.uk/pdbsum/3I43 PDBsum 4AF2 http://www.ebi.ac.uk/pdbsum/4AF2 PROSITE PS01265 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01265 PROSITE PS51352 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51352 PSORT swissprot:TPX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TPX_ECOLI PSORT-B swissprot:TPX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TPX_ECOLI PSORT2 swissprot:TPX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TPX_ECOLI PeroxiBase 6007 http://peroxibase.toulouse.inra.fr/listing.php?action=view&id=6007 Pfam PF08534 http://pfam.xfam.org/family/PF08534 Phobius swissprot:TPX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TPX_ECOLI PhylomeDB P0A862 http://phylomedb.org/?seqid=P0A862 ProteinModelPortal P0A862 http://www.proteinmodelportal.org/query/uniprot/P0A862 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7499381 http://www.ncbi.nlm.nih.gov/pubmed/7499381 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_415840 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415840 RefSeq WP_000084387 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000084387 SMR P0A862 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A862 STRING 511145.b1324 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1324&targetmode=cogs STRING COG2077 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2077&targetmode=cogs SUPFAM SSF52833 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52833 SWISS-2DPAGE P0A862 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A862 UniProtKB TPX_ECOLI http://www.uniprot.org/uniprot/TPX_ECOLI UniProtKB-AC P0A862 http://www.uniprot.org/uniprot/P0A862 charge swissprot:TPX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TPX_ECOLI eggNOG COG2077 http://eggnogapi.embl.de/nog_data/html/tree/COG2077 eggNOG ENOG4108V1J http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108V1J epestfind swissprot:TPX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TPX_ECOLI garnier swissprot:TPX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TPX_ECOLI helixturnhelix swissprot:TPX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TPX_ECOLI hmoment swissprot:TPX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TPX_ECOLI iep swissprot:TPX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TPX_ECOLI inforesidue swissprot:TPX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TPX_ECOLI octanol swissprot:TPX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TPX_ECOLI pepcoil swissprot:TPX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TPX_ECOLI pepdigest swissprot:TPX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TPX_ECOLI pepinfo swissprot:TPX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TPX_ECOLI pepnet swissprot:TPX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TPX_ECOLI pepstats swissprot:TPX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TPX_ECOLI pepwheel swissprot:TPX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TPX_ECOLI pepwindow swissprot:TPX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TPX_ECOLI sigcleave swissprot:TPX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TPX_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES PPTA_ECOLI Kinetic parameters KM=205 uM for enol isomers of phenylpyruvate {ECO 0000269|PubMed 12356301}; KM=220 uM for 2-hydroxy-2,4-pentadienoate {ECO 0000269|PubMed 12356301}; KM=180 uM for (p-hydroxyphenyl)pyruvate {ECO 0000269|PubMed 12356301}; # BioGrid 4262891 27 # DrugBank DB03793 Benzoic Acid # ENZYME REGULATION Inhibited by (E)-2-fluoro-p-hydroxycinnamate. {ECO:0000269|PubMed 12356301}. # EcoGene EG11761 pptA # FUNCTION PPTA_ECOLI Can use enol isomers of phenylpyruvate, 2-hydroxy-2,4- pentadienoate and (p-hydroxyphenyl)pyruvate as substrates. {ECO 0000269|PubMed 12356301}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0016862 intramolecular oxidoreductase activity, interconverting keto- and enol-groups; IEA:UniProtKB-HAMAP. # GO_process GO:0006725 cellular aromatic compound metabolic process; IEA:InterPro. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0008150 biological_process # HAMAP MF_00718 Tautomerase_PptA # IntAct P31992 14 # InterPro IPR004370 4-oxalocrotonate_tautomerase # InterPro IPR014347 Tautomerase/MIF_sf # InterPro IPR017284 Tautomerase_PptA # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00362 Benzoate degradation # KEGG_Pathway ko00621 Dioxin degradation # KEGG_Pathway ko00622 Xylene degradation # MASS SPECTROMETRY Mass=8540; Method=Electrospray; Range=2-77; Evidence={ECO:0000269|PubMed 12356301}; # Organism PPTA_ECOLI Escherichia coli (strain K12) # PATRIC 32118214 VBIEscCol129921_1527 # PDB 1GYJ X-ray; 2.10 A; A/B=2-77 # PDB 1GYX X-ray; 1.35 A; A/B=2-77 # PDB 1GYY X-ray; 1.35 A; A/B=2-77 # PIR H64898 H64898 # PIRSF PIRSF037799 Tautomer_YdcE_prd # Pfam PF01361 Tautomerase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PPTA_ECOLI Tautomerase PptA # RefSeq NP_415978 NC_000913.3 # RefSeq WP_001120143 NZ_LN832404.1 # SIMILARITY Belongs to the 4-oxalocrotonate tautomerase family. PptA subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION PPTA_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 12356301}. # SUPFAM SSF55331 SSF55331 # eggNOG COG1942 LUCA # eggNOG ENOG4105KZK Bacteria BLAST swissprot:PPTA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PPTA_ECOLI BioCyc ECOL316407:JW1456-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1456-MONOMER BioCyc EcoCyc:EG11761-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11761-MONOMER COG COG1942 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1942 DOI 10.1021/bi020271h http://dx.doi.org/10.1021/bi020271h DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB03793 http://www.drugbank.ca/drugs/DB03793 EC_number EC:5.3.2.- http://www.genome.jp/dbget-bin/www_bget?EC:5.3.2.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X60998 http://www.ebi.ac.uk/ena/data/view/X60998 ENZYME 5.3.2.- http://enzyme.expasy.org/EC/5.3.2.- EchoBASE EB1711 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1711 EcoGene EG11761 http://www.ecogene.org/geneInfo.php?eg_id=EG11761 EnsemblBacteria AAC74543 http://www.ensemblgenomes.org/id/AAC74543 EnsemblBacteria AAC74543 http://www.ensemblgenomes.org/id/AAC74543 EnsemblBacteria BAA15092 http://www.ensemblgenomes.org/id/BAA15092 EnsemblBacteria BAA15092 http://www.ensemblgenomes.org/id/BAA15092 EnsemblBacteria BAA15092 http://www.ensemblgenomes.org/id/BAA15092 EnsemblBacteria b1461 http://www.ensemblgenomes.org/id/b1461 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0016862 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016862 GO_process GO:0006725 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006725 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 945731 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945731 HAMAP MF_00718 http://hamap.expasy.org/unirule/MF_00718 HOGENOM HOG000077848 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000077848&db=HOGENOM6 IntAct P31992 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31992* IntEnz 5.3.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.3.2 InterPro IPR004370 http://www.ebi.ac.uk/interpro/entry/IPR004370 InterPro IPR014347 http://www.ebi.ac.uk/interpro/entry/IPR014347 InterPro IPR017284 http://www.ebi.ac.uk/interpro/entry/IPR017284 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1456 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1456 KEGG_Gene eco:b1461 http://www.genome.jp/dbget-bin/www_bget?eco:b1461 KEGG_Orthology KO:K01821 http://www.genome.jp/dbget-bin/www_bget?KO:K01821 KEGG_Pathway ko00362 http://www.genome.jp/kegg-bin/show_pathway?ko00362 KEGG_Pathway ko00621 http://www.genome.jp/kegg-bin/show_pathway?ko00621 KEGG_Pathway ko00622 http://www.genome.jp/kegg-bin/show_pathway?ko00622 KEGG_Reaction rn:R03966 http://www.genome.jp/dbget-bin/www_bget?rn:R03966 KEGG_Reaction rn:R05389 http://www.genome.jp/dbget-bin/www_bget?rn:R05389 OMA IKCFPRD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IKCFPRD PDB 1GYJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1GYJ PDB 1GYX http://www.ebi.ac.uk/pdbe-srv/view/entry/1GYX PDB 1GYY http://www.ebi.ac.uk/pdbe-srv/view/entry/1GYY PDBsum 1GYJ http://www.ebi.ac.uk/pdbsum/1GYJ PDBsum 1GYX http://www.ebi.ac.uk/pdbsum/1GYX PDBsum 1GYY http://www.ebi.ac.uk/pdbsum/1GYY PSORT swissprot:PPTA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PPTA_ECOLI PSORT-B swissprot:PPTA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PPTA_ECOLI PSORT2 swissprot:PPTA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PPTA_ECOLI Pfam PF01361 http://pfam.xfam.org/family/PF01361 Phobius swissprot:PPTA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PPTA_ECOLI ProteinModelPortal P31992 http://www.proteinmodelportal.org/query/uniprot/P31992 PubMed 12356301 http://www.ncbi.nlm.nih.gov/pubmed/12356301 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8387990 http://www.ncbi.nlm.nih.gov/pubmed/8387990 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415978 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415978 RefSeq WP_001120143 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001120143 SMR P31992 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31992 STRING 511145.b1461 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1461&targetmode=cogs STRING COG1942 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1942&targetmode=cogs SUPFAM SSF55331 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55331 UniProtKB PPTA_ECOLI http://www.uniprot.org/uniprot/PPTA_ECOLI UniProtKB-AC P31992 http://www.uniprot.org/uniprot/P31992 charge swissprot:PPTA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PPTA_ECOLI eggNOG COG1942 http://eggnogapi.embl.de/nog_data/html/tree/COG1942 eggNOG ENOG4105KZK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KZK epestfind swissprot:PPTA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PPTA_ECOLI garnier swissprot:PPTA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PPTA_ECOLI helixturnhelix swissprot:PPTA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PPTA_ECOLI hmoment swissprot:PPTA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PPTA_ECOLI iep swissprot:PPTA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PPTA_ECOLI inforesidue swissprot:PPTA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PPTA_ECOLI octanol swissprot:PPTA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PPTA_ECOLI pepcoil swissprot:PPTA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PPTA_ECOLI pepdigest swissprot:PPTA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PPTA_ECOLI pepinfo swissprot:PPTA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PPTA_ECOLI pepnet swissprot:PPTA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PPTA_ECOLI pepstats swissprot:PPTA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PPTA_ECOLI pepwheel swissprot:PPTA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PPTA_ECOLI pepwindow swissprot:PPTA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PPTA_ECOLI sigcleave swissprot:PPTA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PPTA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261327 38 # EcoGene EG13933 rsxA # FUNCTION RSXA_ECOLI Part of a membrane complex involved in electron transport. Required to maintain the reduced state of SoxR. {ECO 0000255|HAMAP-Rule MF_00459, ECO 0000269|PubMed 12773378}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0022900 electron transport chain; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006091 generation of precursor metabolites and energy # HAMAP MF_00459 RsxA_RnfA # InterPro IPR003667 Rnf-Nqr # InterPro IPR011293 Elect_transpt_RnfA/RsxA # Organism RSXA_ECOLI Escherichia coli (strain K12) # PATRIC 32118556 VBIEscCol129921_1698 # PIR E64919 E64919 # PIRSF PIRSF006102 NQR_DE # Pfam PF02508 Rnf-Nqr # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Electron transport complex subunit RsxA {ECO:0000255|HAMAP-Rule MF_00459} # RefSeq NP_416144 NC_000913.3 # RefSeq WP_000133193 NZ_LN832404.1 # SIMILARITY Belongs to the NqrDE/RnfAE family. {ECO:0000255|HAMAP- Rule MF_00459}. # SUBCELLULAR LOCATION RSXA_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_00459, ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255|HAMAP-Rule MF_00459, ECO 0000269|PubMed 15919996}. # SUBUNIT Composed of six subunits; RsxA, RsxB, RsxC, RsxD, RsxE and RsxG. {ECO:0000305|PubMed 12773378}. # TCDB 3.D.6.1:the putative ion (h(+) or na(+))-translocating nadh ferredoxin oxidoreductase (nfo or rnf) family # TIGRFAMs TIGR01943 rnfA # eggNOG COG4657 LUCA # eggNOG ENOG4105DGN Bacteria BLAST swissprot:RSXA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RSXA_ECOLI BioCyc ECOL316407:JW1619-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1619-MONOMER BioCyc EcoCyc:G6871-MONOMER http://biocyc.org/getid?id=EcoCyc:G6871-MONOMER COG COG2209 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2209 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.96.15.8540 http://dx.doi.org/10.1073/pnas.96.15.8540 DOI 10.1093/emboj/cdg252 http://dx.doi.org/10.1093/emboj/cdg252 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3692 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3692 EcoGene EG13933 http://www.ecogene.org/geneInfo.php?eg_id=EG13933 EnsemblBacteria AAC74699 http://www.ensemblgenomes.org/id/AAC74699 EnsemblBacteria AAC74699 http://www.ensemblgenomes.org/id/AAC74699 EnsemblBacteria BAE76486 http://www.ensemblgenomes.org/id/BAE76486 EnsemblBacteria BAE76486 http://www.ensemblgenomes.org/id/BAE76486 EnsemblBacteria BAE76486 http://www.ensemblgenomes.org/id/BAE76486 EnsemblBacteria b1627 http://www.ensemblgenomes.org/id/b1627 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0022900 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022900 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GeneID 946148 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946148 HAMAP MF_00459 http://hamap.expasy.org/unirule/MF_00459 HOGENOM HOG000279324 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000279324&db=HOGENOM6 InParanoid P0A766 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A766 InterPro IPR003667 http://www.ebi.ac.uk/interpro/entry/IPR003667 InterPro IPR011293 http://www.ebi.ac.uk/interpro/entry/IPR011293 KEGG_Gene ecj:JW1619 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1619 KEGG_Gene eco:b1627 http://www.genome.jp/dbget-bin/www_bget?eco:b1627 KEGG_Orthology KO:K03617 http://www.genome.jp/dbget-bin/www_bget?KO:K03617 OMA FTEMVIN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FTEMVIN PSORT swissprot:RSXA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RSXA_ECOLI PSORT-B swissprot:RSXA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RSXA_ECOLI PSORT2 swissprot:RSXA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RSXA_ECOLI Pfam PF02508 http://pfam.xfam.org/family/PF02508 Phobius swissprot:RSXA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RSXA_ECOLI PhylomeDB P0A766 http://phylomedb.org/?seqid=P0A766 ProteinModelPortal P0A766 http://www.proteinmodelportal.org/query/uniprot/P0A766 PubMed 10411911 http://www.ncbi.nlm.nih.gov/pubmed/10411911 PubMed 12773378 http://www.ncbi.nlm.nih.gov/pubmed/12773378 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416144 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416144 RefSeq WP_000133193 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000133193 STRING 511145.b1627 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1627&targetmode=cogs STRING COG2209 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2209&targetmode=cogs TCDB 3.D.6.1 http://www.tcdb.org/search/result.php?tc=3.D.6.1 TIGRFAMs TIGR01943 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01943 UniProtKB RSXA_ECOLI http://www.uniprot.org/uniprot/RSXA_ECOLI UniProtKB-AC P0A766 http://www.uniprot.org/uniprot/P0A766 charge swissprot:RSXA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RSXA_ECOLI eggNOG COG4657 http://eggnogapi.embl.de/nog_data/html/tree/COG4657 eggNOG ENOG4105DGN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DGN epestfind swissprot:RSXA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RSXA_ECOLI garnier swissprot:RSXA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RSXA_ECOLI helixturnhelix swissprot:RSXA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RSXA_ECOLI hmoment swissprot:RSXA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RSXA_ECOLI iep swissprot:RSXA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RSXA_ECOLI inforesidue swissprot:RSXA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RSXA_ECOLI octanol swissprot:RSXA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RSXA_ECOLI pepcoil swissprot:RSXA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RSXA_ECOLI pepdigest swissprot:RSXA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RSXA_ECOLI pepinfo swissprot:RSXA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RSXA_ECOLI pepnet swissprot:RSXA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RSXA_ECOLI pepstats swissprot:RSXA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RSXA_ECOLI pepwheel swissprot:RSXA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RSXA_ECOLI pepwindow swissprot:RSXA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RSXA_ECOLI sigcleave swissprot:RSXA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RSXA_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES NUDK_ECOLI Kinetic parameters KM=0.81 mM for GDP-mannose {ECO 0000269|PubMed 16766526}; Vmax=207 umol/min/mg enzyme with GDP-mannose as substrate {ECO 0000269|PubMed 16766526}; pH dependence Optimum pH is about 8.5. {ECO 0000269|PubMed 16766526}; # BioGrid 4260924 45 # CATALYTIC ACTIVITY GDP-mannose + H(2)O = GMP + mannose-1- phosphate. {ECO:0000269|PubMed 16766526}. # COFACTOR NUDK_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 16766526}; # EcoGene EG12410 nudK # FUNCTION NUDK_ECOLI Catalyzes the hydrolysis of GDP-mannose. Can also use other substrates, catalyzing the hydrolysis of the pyrophosphate bond, releasing a nucleoside monophosphate and a phosphorylated moiety, depending on the substrate. {ECO 0000269|PubMed 16766526}. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0052751 GDP-mannose hydrolase activity; IDA:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # Gene3D 3.90.79.10 -; 1. # IntAct P37128 10 # InterPro IPR000086 NUDIX_hydrolase_dom # InterPro IPR004385 NDP_pyrophosphatase # InterPro IPR015797 NUDIX_hydrolase_dom-like # KEGG_Brite ko01000 Enzymes # Organism NUDK_ECOLI Escherichia coli (strain K12) # PATRIC 32120317 VBIEscCol129921_2561 # PDB 1VIU X-ray; 2.40 A; A/B/C/D=2-191 # PDB 3O52 X-ray; 2.50 A; A/B/C/D/E=1-191 # PDB 3O61 X-ray; 2.45 A; A/B/C/D=1-191 # PDB 3O69 X-ray; 2.10 A; A/B=1-191 # PDB 3O6Z X-ray; 2.05 A; A/B=1-191 # PIR B65022 B65022 # PROSITE PS51462 NUDIX # Pfam PF00293 NUDIX # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NUDK_ECOLI GDP-mannose pyrophosphatase NudK # RefSeq NP_416962 NC_000913.3 # RefSeq WP_001300814 NZ_LN832404.1 # SIMILARITY Belongs to the Nudix hydrolase family. NudK subfamily. {ECO 0000305}. # SIMILARITY Contains 1 nudix hydrolase domain. {ECO:0000255|PROSITE-ProRule PRU00794}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 16021622}. # SUPFAM SSF55811 SSF55811 # TIGRFAMs TIGR00052 TIGR00052 # eggNOG ENOG4107VIJ Bacteria # eggNOG ENOG410YMTX LUCA BLAST swissprot:NUDK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NUDK_ECOLI BioCyc ECOL316407:JW2451-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2451-MONOMER BioCyc EcoCyc:EG12410-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12410-MONOMER BioCyc MetaCyc:EG12410-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12410-MONOMER COG COG0494 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0494 DOI 10.1002/prot.20541 http://dx.doi.org/10.1002/prot.20541 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M603407200 http://dx.doi.org/10.1074/jbc.M603407200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.1.- http://www.genome.jp/dbget-bin/www_bget?EC:3.6.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L34011 http://www.ebi.ac.uk/ena/data/view/L34011 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.6.1.- http://enzyme.expasy.org/EC/3.6.1.- EchoBASE EB2309 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2309 EcoGene EG12410 http://www.ecogene.org/geneInfo.php?eg_id=EG12410 EnsemblBacteria AAC75520 http://www.ensemblgenomes.org/id/AAC75520 EnsemblBacteria AAC75520 http://www.ensemblgenomes.org/id/AAC75520 EnsemblBacteria BAA16341 http://www.ensemblgenomes.org/id/BAA16341 EnsemblBacteria BAA16341 http://www.ensemblgenomes.org/id/BAA16341 EnsemblBacteria BAA16341 http://www.ensemblgenomes.org/id/BAA16341 EnsemblBacteria b2467 http://www.ensemblgenomes.org/id/b2467 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0052751 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052751 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.90.79.10 http://www.cathdb.info/version/latest/superfamily/3.90.79.10 GeneID 947072 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947072 HOGENOM HOG000045855 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000045855&db=HOGENOM6 InParanoid P37128 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37128 IntAct P37128 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37128* IntEnz 3.6.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.1 InterPro IPR000086 http://www.ebi.ac.uk/interpro/entry/IPR000086 InterPro IPR004385 http://www.ebi.ac.uk/interpro/entry/IPR004385 InterPro IPR015797 http://www.ebi.ac.uk/interpro/entry/IPR015797 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2451 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2451 KEGG_Gene eco:b2467 http://www.genome.jp/dbget-bin/www_bget?eco:b2467 KEGG_Orthology KO:K12945 http://www.genome.jp/dbget-bin/www_bget?KO:K12945 OMA CIRRETE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CIRRETE PDB 1VIU http://www.ebi.ac.uk/pdbe-srv/view/entry/1VIU PDB 3O52 http://www.ebi.ac.uk/pdbe-srv/view/entry/3O52 PDB 3O61 http://www.ebi.ac.uk/pdbe-srv/view/entry/3O61 PDB 3O69 http://www.ebi.ac.uk/pdbe-srv/view/entry/3O69 PDB 3O6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3O6Z PDBsum 1VIU http://www.ebi.ac.uk/pdbsum/1VIU PDBsum 3O52 http://www.ebi.ac.uk/pdbsum/3O52 PDBsum 3O61 http://www.ebi.ac.uk/pdbsum/3O61 PDBsum 3O69 http://www.ebi.ac.uk/pdbsum/3O69 PDBsum 3O6Z http://www.ebi.ac.uk/pdbsum/3O6Z PROSITE PS51462 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51462 PSORT swissprot:NUDK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NUDK_ECOLI PSORT-B swissprot:NUDK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NUDK_ECOLI PSORT2 swissprot:NUDK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NUDK_ECOLI Pfam PF00293 http://pfam.xfam.org/family/PF00293 Phobius swissprot:NUDK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NUDK_ECOLI PhylomeDB P37128 http://phylomedb.org/?seqid=P37128 ProteinModelPortal P37128 http://www.proteinmodelportal.org/query/uniprot/P37128 PubMed 16021622 http://www.ncbi.nlm.nih.gov/pubmed/16021622 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16766526 http://www.ncbi.nlm.nih.gov/pubmed/16766526 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416962 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416962 RefSeq WP_001300814 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300814 SMR P37128 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37128 STRING 511145.b2467 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2467&targetmode=cogs STRING COG0494 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0494&targetmode=cogs SUPFAM SSF55811 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55811 TIGRFAMs TIGR00052 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00052 UniProtKB NUDK_ECOLI http://www.uniprot.org/uniprot/NUDK_ECOLI UniProtKB-AC P37128 http://www.uniprot.org/uniprot/P37128 charge swissprot:NUDK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NUDK_ECOLI eggNOG ENOG4107VIJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107VIJ eggNOG ENOG410YMTX http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YMTX epestfind swissprot:NUDK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NUDK_ECOLI garnier swissprot:NUDK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NUDK_ECOLI helixturnhelix swissprot:NUDK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NUDK_ECOLI hmoment swissprot:NUDK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NUDK_ECOLI iep swissprot:NUDK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NUDK_ECOLI inforesidue swissprot:NUDK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NUDK_ECOLI octanol swissprot:NUDK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NUDK_ECOLI pepcoil swissprot:NUDK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NUDK_ECOLI pepdigest swissprot:NUDK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NUDK_ECOLI pepinfo swissprot:NUDK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NUDK_ECOLI pepnet swissprot:NUDK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NUDK_ECOLI pepstats swissprot:NUDK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NUDK_ECOLI pepwheel swissprot:NUDK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NUDK_ECOLI pepwindow swissprot:NUDK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NUDK_ECOLI sigcleave swissprot:NUDK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NUDK_ECOLI ## Database ID URL or Descriptions # AltName MBHM_ECOLI Membrane-bound hydrogenase 2 large subunit # AltName MBHM_ECOLI NiFe hydrogenase # BioGrid 4262375 11 # CATALYTIC ACTIVITY MBHM_ECOLI H(2) + A = AH(2). # COFACTOR MBHM_ECOLI Name=Ni(2+); Xref=ChEBI CHEBI 49786; Evidence={ECO 0000250}; Note=Binds 1 nickel ion per subunit. {ECO 0000250}; # EcoGene EG11801 hybC # FUNCTION MBHM_ECOLI This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD2 is involved in hydrogen uptake. # GO_component GO:0031236 extrinsic component of periplasmic side of plasma membrane; IDA:EcoCyc. # GO_function GO:0008901 ferredoxin hydrogenase activity; IEA:InterPro. # GO_function GO:0016151 nickel cation binding; ISM:EcoCyc. # GO_function GO:0033748 hydrogenase (acceptor) activity; IEA:UniProtKB-EC. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # Gene3D 1.10.645.10 -; 1. # IntAct P0ACE0 15 # InterPro IPR001501 Ni-dep_hyd_lsu # InterPro IPR018194 Ni-dep_hyd_lsu_Ni_BS # InterPro IPR029014 NiFe_Hase-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00633 Nitrotoluene degradation # Organism MBHM_ECOLI Escherichia coli (strain K12) # PATRIC 32121404 VBIEscCol129921_3089 # PIR C55516 C55516 # PROSITE PS00507 NI_HGENASE_L_1 # PROSITE PS00508 NI_HGENASE_L_2 # Pfam PF00374 NiFeSe_Hases # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MBHM_ECOLI Hydrogenase-2 large chain # RefSeq NP_417468 NC_000913.3 # RefSeq WP_000083065 NZ_LN832404.1 # SIMILARITY Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. {ECO 0000305}. # SUBCELLULAR LOCATION MBHM_ECOLI Cell membrane; Peripheral membrane protein. # SUBUNIT MBHM_ECOLI Heterodimer of a large and a small subunit. # SUPFAM SSF56762 SSF56762 # eggNOG COG0374 LUCA # eggNOG ENOG4105DPX Bacteria BLAST swissprot:MBHM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MBHM_ECOLI BioCyc ECOL316407:JW2962-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2962-MONOMER BioCyc EcoCyc:HYBC-MONOMER http://biocyc.org/getid?id=EcoCyc:HYBC-MONOMER BioCyc MetaCyc:HYBC-MONOMER http://biocyc.org/getid?id=MetaCyc:HYBC-MONOMER COG COG0374 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0374 DIP DIP-36022N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36022N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1432-1327.1998.2550746.x http://dx.doi.org/10.1046/j.1432-1327.1998.2550746.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.12.99.6 http://www.genome.jp/dbget-bin/www_bget?EC:1.12.99.6 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U09177 http://www.ebi.ac.uk/ena/data/view/U09177 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 ENZYME 1.12.99.6 http://enzyme.expasy.org/EC/1.12.99.6 EchoBASE EB1749 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1749 EcoGene EG11801 http://www.ecogene.org/geneInfo.php?eg_id=EG11801 EnsemblBacteria AAC76030 http://www.ensemblgenomes.org/id/AAC76030 EnsemblBacteria AAC76030 http://www.ensemblgenomes.org/id/AAC76030 EnsemblBacteria BAE77055 http://www.ensemblgenomes.org/id/BAE77055 EnsemblBacteria BAE77055 http://www.ensemblgenomes.org/id/BAE77055 EnsemblBacteria BAE77055 http://www.ensemblgenomes.org/id/BAE77055 EnsemblBacteria b2994 http://www.ensemblgenomes.org/id/b2994 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0031236 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031236 GO_function GO:0008901 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008901 GO_function GO:0016151 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016151 GO_function GO:0033748 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033748 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 1.10.645.10 http://www.cathdb.info/version/latest/superfamily/1.10.645.10 GeneID 945182 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945182 HOGENOM HOG000278799 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278799&db=HOGENOM6 InParanoid P0ACE0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACE0 IntAct P0ACE0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACE0* IntEnz 1.12.99.6 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.12.99.6 InterPro IPR001501 http://www.ebi.ac.uk/interpro/entry/IPR001501 InterPro IPR018194 http://www.ebi.ac.uk/interpro/entry/IPR018194 InterPro IPR029014 http://www.ebi.ac.uk/interpro/entry/IPR029014 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2962 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2962 KEGG_Gene eco:b2994 http://www.genome.jp/dbget-bin/www_bget?eco:b2994 KEGG_Orthology KO:K06281 http://www.genome.jp/dbget-bin/www_bget?KO:K06281 KEGG_Pathway ko00633 http://www.genome.jp/kegg-bin/show_pathway?ko00633 KEGG_Reaction rn:R08034 http://www.genome.jp/dbget-bin/www_bget?rn:R08034 MINT MINT-1254866 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1254866 OMA KMTAIFG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KMTAIFG PROSITE PS00507 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00507 PROSITE PS00508 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00508 PSORT swissprot:MBHM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MBHM_ECOLI PSORT-B swissprot:MBHM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MBHM_ECOLI PSORT2 swissprot:MBHM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MBHM_ECOLI Pfam PF00374 http://pfam.xfam.org/family/PF00374 Phobius swissprot:MBHM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MBHM_ECOLI PhylomeDB P0ACE0 http://phylomedb.org/?seqid=P0ACE0 ProteinModelPortal P0ACE0 http://www.proteinmodelportal.org/query/uniprot/P0ACE0 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8021226 http://www.ncbi.nlm.nih.gov/pubmed/8021226 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9738917 http://www.ncbi.nlm.nih.gov/pubmed/9738917 RefSeq NP_417468 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417468 RefSeq WP_000083065 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000083065 SMR P0ACE0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACE0 STRING 511145.b2994 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2994&targetmode=cogs STRING COG0374 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0374&targetmode=cogs SUPFAM SSF56762 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56762 UniProtKB MBHM_ECOLI http://www.uniprot.org/uniprot/MBHM_ECOLI UniProtKB-AC P0ACE0 http://www.uniprot.org/uniprot/P0ACE0 charge swissprot:MBHM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MBHM_ECOLI eggNOG COG0374 http://eggnogapi.embl.de/nog_data/html/tree/COG0374 eggNOG ENOG4105DPX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DPX epestfind swissprot:MBHM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MBHM_ECOLI garnier swissprot:MBHM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MBHM_ECOLI helixturnhelix swissprot:MBHM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MBHM_ECOLI hmoment swissprot:MBHM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MBHM_ECOLI iep swissprot:MBHM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MBHM_ECOLI inforesidue swissprot:MBHM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MBHM_ECOLI octanol swissprot:MBHM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MBHM_ECOLI pepcoil swissprot:MBHM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MBHM_ECOLI pepdigest swissprot:MBHM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MBHM_ECOLI pepinfo swissprot:MBHM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MBHM_ECOLI pepnet swissprot:MBHM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MBHM_ECOLI pepstats swissprot:MBHM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MBHM_ECOLI pepwheel swissprot:MBHM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MBHM_ECOLI pepwindow swissprot:MBHM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MBHM_ECOLI sigcleave swissprot:MBHM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MBHM_ECOLI ## Database ID URL or Descriptions # AltName FTNA_ECOLI Ferritin-1 # BioGrid 4263007 5 # CATALYTIC ACTIVITY 4 Fe(2+) + O(2) + 6 H(2)O = 4 (FeO(OH)) + 8 H(+). {ECO:0000269|PubMed 24380371}. # EcoGene EG10921 ftnA # FUNCTION FTNA_ECOLI Iron-storage protein. {ECO 0000269|PubMed 11254384}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0004322 ferroxidase activity; IDA:EcoCyc. # GO_function GO:0008199 ferric iron binding; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0006826 iron ion transport; IEA:InterPro. # GO_process GO:0006880 intracellular sequestering of iron ion; IMP:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0006979 response to oxidative stress; IDA:CACAO. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # Gene3D 1.20.1260.10 -; 1. # IntAct P0A998 2 # InterPro IPR001519 Ferritin # InterPro IPR008331 Ferritin_DPS_dom # InterPro IPR009040 Ferritin-like_diiron # InterPro IPR009078 Ferritin-like_SF # InterPro IPR012347 Ferritin-rel # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00860 Porphyrin and chlorophyll metabolism # Organism FTNA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11431 PTHR11431 # PATRIC 32119139 VBIEscCol129921_1987 # PDB 1EUM X-ray; 2.05 A; A/B/C/D/E/F=1-165 # PDB 4XGS X-ray; 2.25 A; A/B/C/D/E/F=2-165 # PDB 4ZTT X-ray; 1.83 A; A/B/C/D/E/F=2-165 # PIR S14069 S14069 # PROSITE PS50905 FERRITIN_LIKE # Pfam PF00210 Ferritin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FTNA_ECOLI Bacterial non-heme ferritin # RefSeq NP_416418 NC_000913.3 # RefSeq WP_000917208 NZ_LN832404.1 # SIMILARITY Belongs to the ferritin family. Prokaryotic subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ferritin-like diiron domain. {ECO:0000255|PROSITE-ProRule PRU00085}. # SUBCELLULAR LOCATION FTNA_ECOLI Cytoplasm. # SUBUNIT FTNA_ECOLI Homooligomer of 24 subunits that assemble into a spherical protein shell (12 +/- 1 nM diameter) that can sequester at least 2000 iron atoms. {ECO 0000269|PubMed 11254384, ECO 0000269|PubMed 8281950}. # SUPFAM SSF47240 SSF47240 # eggNOG COG1528 LUCA # eggNOG ENOG41090A1 Bacteria BLAST swissprot:FTNA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FTNA_ECOLI BioCyc ECOL316407:JW1893-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1893-MONOMER BioCyc EcoCyc:EG10921-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10921-MONOMER BioCyc MetaCyc:EG10921-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10921-MONOMER COG COG1528 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1528 DIP DIP-36198N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36198N DOI 10.1006/jmbi.2001.4475 http://dx.doi.org/10.1006/jmbi.2001.4475 DOI 10.1007/BF00261694 http://dx.doi.org/10.1007/BF00261694 DOI 10.1016/S0014-5793(98)00867-9 http://dx.doi.org/10.1016/S0014-5793(98)00867-9 DOI 10.1021/bi401517f http://dx.doi.org/10.1021/bi401517f DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1111/j.1432-1033.1993.tb18457.x http://dx.doi.org/10.1111/j.1432-1033.1993.tb18457.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.16.3.2 http://www.genome.jp/dbget-bin/www_bget?EC:1.16.3.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U35066 http://www.ebi.ac.uk/ena/data/view/U35066 EMBL X53513 http://www.ebi.ac.uk/ena/data/view/X53513 ENZYME 1.16.3.2 http://enzyme.expasy.org/EC/1.16.3.2 EchoBASE EB0914 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0914 EcoGene EG10921 http://www.ecogene.org/geneInfo.php?eg_id=EG10921 EnsemblBacteria AAC74975 http://www.ensemblgenomes.org/id/AAC74975 EnsemblBacteria AAC74975 http://www.ensemblgenomes.org/id/AAC74975 EnsemblBacteria BAA15728 http://www.ensemblgenomes.org/id/BAA15728 EnsemblBacteria BAA15728 http://www.ensemblgenomes.org/id/BAA15728 EnsemblBacteria BAA15728 http://www.ensemblgenomes.org/id/BAA15728 EnsemblBacteria b1905 http://www.ensemblgenomes.org/id/b1905 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004322 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004322 GO_function GO:0008199 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008199 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0006826 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006826 GO_process GO:0006880 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006880 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0006979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.20.1260.10 http://www.cathdb.info/version/latest/superfamily/1.20.1260.10 GeneID 946410 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946410 HOGENOM HOG000223382 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000223382&db=HOGENOM6 InParanoid P0A998 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A998 IntAct P0A998 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A998* IntEnz 1.16.3.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.16.3.2 InterPro IPR001519 http://www.ebi.ac.uk/interpro/entry/IPR001519 InterPro IPR008331 http://www.ebi.ac.uk/interpro/entry/IPR008331 InterPro IPR009040 http://www.ebi.ac.uk/interpro/entry/IPR009040 InterPro IPR009078 http://www.ebi.ac.uk/interpro/entry/IPR009078 InterPro IPR012347 http://www.ebi.ac.uk/interpro/entry/IPR012347 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1893 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1893 KEGG_Gene eco:b1905 http://www.genome.jp/dbget-bin/www_bget?eco:b1905 KEGG_Orthology KO:K02217 http://www.genome.jp/dbget-bin/www_bget?KO:K02217 KEGG_Pathway ko00860 http://www.genome.jp/kegg-bin/show_pathway?ko00860 KEGG_Reaction rn:R00078 http://www.genome.jp/dbget-bin/www_bget?rn:R00078 OMA CEDKGFE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CEDKGFE PANTHER PTHR11431 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11431 PDB 1EUM http://www.ebi.ac.uk/pdbe-srv/view/entry/1EUM PDB 4XGS http://www.ebi.ac.uk/pdbe-srv/view/entry/4XGS PDB 4ZTT http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZTT PDBsum 1EUM http://www.ebi.ac.uk/pdbsum/1EUM PDBsum 4XGS http://www.ebi.ac.uk/pdbsum/4XGS PDBsum 4ZTT http://www.ebi.ac.uk/pdbsum/4ZTT PROSITE PS50905 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50905 PSORT swissprot:FTNA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FTNA_ECOLI PSORT-B swissprot:FTNA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FTNA_ECOLI PSORT2 swissprot:FTNA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FTNA_ECOLI Pfam PF00210 http://pfam.xfam.org/family/PF00210 Phobius swissprot:FTNA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FTNA_ECOLI PhylomeDB P0A998 http://phylomedb.org/?seqid=P0A998 ProteinModelPortal P0A998 http://www.proteinmodelportal.org/query/uniprot/P0A998 PubMed 11254384 http://www.ncbi.nlm.nih.gov/pubmed/11254384 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2017145 http://www.ncbi.nlm.nih.gov/pubmed/2017145 PubMed 24380371 http://www.ncbi.nlm.nih.gov/pubmed/24380371 PubMed 8281950 http://www.ncbi.nlm.nih.gov/pubmed/8281950 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9720927 http://www.ncbi.nlm.nih.gov/pubmed/9720927 RefSeq NP_416418 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416418 RefSeq WP_000917208 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000917208 SMR P0A998 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A998 STRING 511145.b1905 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1905&targetmode=cogs STRING COG1528 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1528&targetmode=cogs SUPFAM SSF47240 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47240 UniProtKB FTNA_ECOLI http://www.uniprot.org/uniprot/FTNA_ECOLI UniProtKB-AC P0A998 http://www.uniprot.org/uniprot/P0A998 charge swissprot:FTNA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FTNA_ECOLI eggNOG COG1528 http://eggnogapi.embl.de/nog_data/html/tree/COG1528 eggNOG ENOG41090A1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41090A1 epestfind swissprot:FTNA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FTNA_ECOLI garnier swissprot:FTNA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FTNA_ECOLI helixturnhelix swissprot:FTNA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FTNA_ECOLI hmoment swissprot:FTNA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FTNA_ECOLI iep swissprot:FTNA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FTNA_ECOLI inforesidue swissprot:FTNA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FTNA_ECOLI octanol swissprot:FTNA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FTNA_ECOLI pepcoil swissprot:FTNA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FTNA_ECOLI pepdigest swissprot:FTNA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FTNA_ECOLI pepinfo swissprot:FTNA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FTNA_ECOLI pepnet swissprot:FTNA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FTNA_ECOLI pepstats swissprot:FTNA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FTNA_ECOLI pepwheel swissprot:FTNA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FTNA_ECOLI pepwindow swissprot:FTNA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FTNA_ECOLI sigcleave swissprot:FTNA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FTNA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260338 11 # CATALYTIC ACTIVITY RND_ECOLI Exonucleolytic cleavage that removes extra residues from the 3'-terminus of tRNA to produce 5'- mononucleotides. {ECO 0000255|HAMAP-Rule MF_01899, ECO 0000269|PubMed 6263886}. # COFACTOR RND_ECOLI Name=a divalent metal cation; Xref=ChEBI CHEBI 60240; Evidence={ECO 0000255|HAMAP-Rule MF_01899, ECO 0000269|PubMed 6263886}; # EcoGene EG10858 rnd # FUNCTION RND_ECOLI Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides. {ECO 0000255|HAMAP- Rule MF_01899, ECO 0000269|PubMed 3041371, ECO 0000269|PubMed 6263886}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0000166 nucleotide binding; IEA:InterPro. # GO_function GO:0003676 nucleic acid binding; IEA:InterPro. # GO_function GO:0004540 ribonuclease activity; IMP:EcoCyc. # GO_function GO:0008408 3'-5' exonuclease activity; IEA:InterPro. # GO_function GO:0033890 ribonuclease D activity; IEA:UniProtKB-HAMAP. # GO_process GO:0008033 tRNA processing; IMP:EcoCyc. # GO_process GO:0042780 tRNA 3'-end processing; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0004518 nuclease activity # GOslim_process GO:0006399 tRNA metabolic process # Gene3D 3.30.420.10 -; 1. # HAMAP MF_01899 RNase_D # InterPro IPR002121 HRDC_dom # InterPro IPR002562 3'-5'_exonuclease_dom # InterPro IPR006292 RNase_D # InterPro IPR010997 HRDC-like # InterPro IPR012337 RNaseH-like_dom # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # Organism RND_ECOLI Escherichia coli (strain K12) # PATRIC 32118925 VBIEscCol129921_1880 # PDB 1YT3 X-ray; 1.60 A; A=1-375 # PIR S01223 NRECD # PROSITE PS50967 HRDC # Pfam PF00570 HRDC # Pfam PF01612 DNA_pol_A_exo1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Ribonuclease D {ECO:0000255|HAMAP-Rule MF_01899} # RefSeq NP_416318 NC_000913.3 # SIMILARITY Belongs to the RNase D family. {ECO:0000255|HAMAP- Rule MF_01899}. # SIMILARITY Contains 1 3'-5' exonuclease domain. {ECO:0000255|HAMAP-Rule MF_01899}. # SIMILARITY Contains 1 HRDC domain. {ECO:0000255|HAMAP- Rule MF_01899}. # SMART SM00341 HRDC # SMART SM00474 35EXOc # SUBCELLULAR LOCATION RND_ECOLI Cytoplasm. # SUPFAM SSF47819 SSF47819; 2 # SUPFAM SSF53098 SSF53098 # TIGRFAMs TIGR01388 rnd # eggNOG COG0349 LUCA # eggNOG ENOG4105ZIE Bacteria BLAST swissprot:RND_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RND_ECOLI BioCyc ECOL316407:JW1793-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1793-MONOMER BioCyc EcoCyc:EG10858-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10858-MONOMER BioCyc MetaCyc:EG10858-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10858-MONOMER COG COG0349 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0349 DOI 10.1007/BF00280412 http://dx.doi.org/10.1007/BF00280412 DOI 10.1016/j.str.2005.04.015 http://dx.doi.org/10.1016/j.str.2005.04.015 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/nar/16.14.6265 http://dx.doi.org/10.1093/nar/16.14.6265 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.13.5 {ECO:0000255|HAMAP-Rule:MF_01899} http://www.genome.jp/dbget-bin/www_bget?EC:3.1.13.5 {ECO:0000255|HAMAP-Rule:MF_01899} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X07055 http://www.ebi.ac.uk/ena/data/view/X07055 EMBL X70994 http://www.ebi.ac.uk/ena/data/view/X70994 ENZYME 3.1.13.5 {ECO:0000255|HAMAP-Rule:MF_01899} http://enzyme.expasy.org/EC/3.1.13.5 {ECO:0000255|HAMAP-Rule:MF_01899} EchoBASE EB0851 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0851 EcoGene EG10858 http://www.ecogene.org/geneInfo.php?eg_id=EG10858 EnsemblBacteria AAC74874 http://www.ensemblgenomes.org/id/AAC74874 EnsemblBacteria AAC74874 http://www.ensemblgenomes.org/id/AAC74874 EnsemblBacteria BAA15599 http://www.ensemblgenomes.org/id/BAA15599 EnsemblBacteria BAA15599 http://www.ensemblgenomes.org/id/BAA15599 EnsemblBacteria BAA15599 http://www.ensemblgenomes.org/id/BAA15599 EnsemblBacteria b1804 http://www.ensemblgenomes.org/id/b1804 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000166 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000166 GO_function GO:0003676 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003676 GO_function GO:0004540 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004540 GO_function GO:0008408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008408 GO_function GO:0033890 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033890 GO_process GO:0008033 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008033 GO_process GO:0042780 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042780 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 Gene3D 3.30.420.10 http://www.cathdb.info/version/latest/superfamily/3.30.420.10 GeneID 946328 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946328 HAMAP MF_01899 http://hamap.expasy.org/unirule/MF_01899 HOGENOM HOG000277560 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000277560&db=HOGENOM6 InParanoid P09155 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P09155 IntAct P09155 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P09155* IntEnz 3.1.13.5 {ECO:0000255|HAMAP-Rule:MF_01899} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.13.5 {ECO:0000255|HAMAP-Rule:MF_01899} InterPro IPR002121 http://www.ebi.ac.uk/interpro/entry/IPR002121 InterPro IPR002562 http://www.ebi.ac.uk/interpro/entry/IPR002562 InterPro IPR006292 http://www.ebi.ac.uk/interpro/entry/IPR006292 InterPro IPR010997 http://www.ebi.ac.uk/interpro/entry/IPR010997 InterPro IPR012337 http://www.ebi.ac.uk/interpro/entry/IPR012337 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW1793 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1793 KEGG_Gene eco:b1804 http://www.genome.jp/dbget-bin/www_bget?eco:b1804 KEGG_Orthology KO:K03684 http://www.genome.jp/dbget-bin/www_bget?KO:K03684 MINT MINT-1309170 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1309170 OMA ITDWAPF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ITDWAPF PDB 1YT3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1YT3 PDBsum 1YT3 http://www.ebi.ac.uk/pdbsum/1YT3 PROSITE PS50967 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50967 PSORT swissprot:RND_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RND_ECOLI PSORT-B swissprot:RND_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RND_ECOLI PSORT2 swissprot:RND_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RND_ECOLI Pfam PF00570 http://pfam.xfam.org/family/PF00570 Pfam PF01612 http://pfam.xfam.org/family/PF01612 Phobius swissprot:RND_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RND_ECOLI PhylomeDB P09155 http://phylomedb.org/?seqid=P09155 ProteinModelPortal P09155 http://www.proteinmodelportal.org/query/uniprot/P09155 PubMed 16004870 http://www.ncbi.nlm.nih.gov/pubmed/16004870 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3041371 http://www.ncbi.nlm.nih.gov/pubmed/3041371 PubMed 6263886 http://www.ncbi.nlm.nih.gov/pubmed/6263886 PubMed 8107670 http://www.ncbi.nlm.nih.gov/pubmed/8107670 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416318 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416318 SMART SM00341 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00341 SMART SM00474 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00474 SMR P09155 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P09155 STRING 511145.b1804 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1804&targetmode=cogs STRING COG0349 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0349&targetmode=cogs SUPFAM SSF47819 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47819 SUPFAM SSF53098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098 TIGRFAMs TIGR01388 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01388 UniProtKB RND_ECOLI http://www.uniprot.org/uniprot/RND_ECOLI UniProtKB-AC P09155 http://www.uniprot.org/uniprot/P09155 charge swissprot:RND_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RND_ECOLI eggNOG COG0349 http://eggnogapi.embl.de/nog_data/html/tree/COG0349 eggNOG ENOG4105ZIE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ZIE epestfind swissprot:RND_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RND_ECOLI garnier swissprot:RND_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RND_ECOLI helixturnhelix swissprot:RND_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RND_ECOLI hmoment swissprot:RND_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RND_ECOLI iep swissprot:RND_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RND_ECOLI inforesidue swissprot:RND_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RND_ECOLI octanol swissprot:RND_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RND_ECOLI pepcoil swissprot:RND_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RND_ECOLI pepdigest swissprot:RND_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RND_ECOLI pepinfo swissprot:RND_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RND_ECOLI pepnet swissprot:RND_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RND_ECOLI pepstats swissprot:RND_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RND_ECOLI pepwheel swissprot:RND_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RND_ECOLI pepwindow swissprot:RND_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RND_ECOLI sigcleave swissprot:RND_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RND_ECOLI ## Database ID URL or Descriptions # DrugBank DB00759 Tetracycline # EcoGene EG10902 rpsC # FUNCTION RS3_ECOLI Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity). {ECO 0000250}. # FUNCTION RS3_ECOLI Plays a role in mRNA unwinding by the ribosome, possibly by forming part of a processivity clamp. {ECO 0000269|PubMed 15652481}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0022627 cytosolic small ribosomal subunit; IDA:EcoliWiki. # GO_function GO:0003729 mRNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0003735 structural constituent of ribosome; IBA:GO_Central. # GO_function GO:0019843 rRNA binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006412 translation; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003729 mRNA binding # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_function GO:0019843 rRNA binding # GOslim_process GO:0006412 translation # Gene3D 3.30.1140.32 -; 1. # Gene3D 3.30.300.20 -; 1. # HAMAP MF_01309_B Ribosomal_S3_B # IntAct P0A7V3 188 # InterPro IPR001351 Ribosomal_S3_C # InterPro IPR004044 KH_dom_type_2 # InterPro IPR004087 KH_dom # InterPro IPR005704 Ribosomal_S3_bac # InterPro IPR009019 KH_prok-type # InterPro IPR015946 KH_dom-like_a/b # InterPro IPR018280 Ribosomal_S3_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 M00179 Ribosome, archaea # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=25851.9; Method=MALDI; Range=2-233; Evidence={ECO:0000269|PubMed 10094780}; # Organism RS3_ECOLI Escherichia coli (strain K12) # PATRIC 32122060 VBIEscCol129921_3407 # PDB 1M5G Model; -; C=2-207 # PDB 2YKR EM; 9.80 A; C=2-207 # PDB 3J9Y EM; 3.90 A; c=1-233 # PDB 3J9Z EM; 3.60 A; SC=2-233 # PDB 3JA1 EM; 3.60 A; SC=2-233 # PDB 3JBU EM; 3.64 A; C=1-233 # PDB 3JBV EM; 3.32 A; C=1-233 # PDB 3JCD EM; 3.70 A; c=1-233 # PDB 3JCE EM; 3.20 A; c=1-233 # PDB 3JCJ EM; 3.70 A; h=1-233 # PDB 3JCN EM; 4.60 A; c=1-233 # PDB 4A2I EM; 16.50 A; C=2-207 # PDB 4ADV EM; 13.50 A; C=2-233 # PDB 4ODQ X-ray; 2.00 A; B=11-25 # PDB 4U1U X-ray; 2.95 A; AC/CC=2-207 # PDB 4U1V X-ray; 3.00 A; AC/CC=2-207 # PDB 4U20 X-ray; 2.90 A; AC/CC=2-207 # PDB 4U24 X-ray; 2.90 A; AC/CC=2-207 # PDB 4U25 X-ray; 2.90 A; AC/CC=2-207 # PDB 4U26 X-ray; 2.80 A; AC/CC=2-207 # PDB 4U27 X-ray; 2.80 A; AC/CC=2-207 # PDB 4V47 EM; 12.30 A; BC=2-233 # PDB 4V48 EM; 11.50 A; BC=2-233 # PDB 4V4H X-ray; 3.46 A; AC/CC=1-233 # PDB 4V4Q X-ray; 3.46 A; AC/CC=2-233 # PDB 4V4V EM; 15.00 A; AC=2-207 # PDB 4V4W EM; 15.00 A; AC=2-207 # PDB 4V50 X-ray; 3.22 A; AC/CC=2-233 # PDB 4V52 X-ray; 3.21 A; AC/CC=2-233 # PDB 4V53 X-ray; 3.54 A; AC/CC=2-233 # PDB 4V54 X-ray; 3.30 A; AC/CC=2-233 # PDB 4V55 X-ray; 4.00 A; AC/CC=2-233 # PDB 4V56 X-ray; 3.93 A; AC/CC=2-233 # PDB 4V57 X-ray; 3.50 A; AC/CC=2-233 # PDB 4V5B X-ray; 3.74 A; BC/DC=2-233 # PDB 4V5H EM; 5.80 A; AC=2-207 # PDB 4V5Y X-ray; 4.45 A; AC/CC=2-233 # PDB 4V64 X-ray; 3.50 A; AC/CC=2-233 # PDB 4V65 EM; 9.00 A; AO=1-233 # PDB 4V66 EM; 9.00 A; AO=1-233 # PDB 4V69 EM; 6.70 A; AC=2-207 # PDB 4V6C X-ray; 3.19 A; AC/CC=1-233 # PDB 4V6D X-ray; 3.81 A; AC/CC=1-233 # PDB 4V6E X-ray; 3.71 A; AC/CC=1-233 # PDB 4V6K EM; 8.25 A; BG=1-233 # PDB 4V6L EM; 13.20 A; AG=1-233 # PDB 4V6M EM; 7.10 A; AC=2-233 # PDB 4V6N EM; 12.10 A; BF=2-233 # PDB 4V6O EM; 14.70 A; AF=2-233 # PDB 4V6P EM; 13.50 A; AF=2-233 # PDB 4V6Q EM; 11.50 A; AF=2-233 # PDB 4V6R EM; 11.50 A; AF=2-233 # PDB 4V6S EM; 13.10 A; BE=2-233 # PDB 4V6T EM; 8.30 A; AC=2-207 # PDB 4V6V EM; 9.80 A; AC=2-233 # PDB 4V6Y EM; 12.00 A; AC=1-207 # PDB 4V6Z EM; 12.00 A; AC=1-207 # PDB 4V70 EM; 17.00 A; AC=1-207 # PDB 4V71 EM; 20.00 A; AC=1-207 # PDB 4V72 EM; 13.00 A; AC=1-207 # PDB 4V73 EM; 15.00 A; AC=1-207 # PDB 4V74 EM; 17.00 A; AC=1-207 # PDB 4V75 EM; 12.00 A; AC=1-207 # PDB 4V76 EM; 17.00 A; AC=1-207 # PDB 4V77 EM; 17.00 A; AC=1-207 # PDB 4V78 EM; 20.00 A; AC=1-207 # PDB 4V79 EM; 15.00 A; AC=1-207 # PDB 4V7A EM; 9.00 A; AC=1-207 # PDB 4V7B EM; 6.80 A; AC=1-233 # PDB 4V7C EM; 7.60 A; AC=2-233 # PDB 4V7D EM; 7.60 A; BC=2-233 # PDB 4V7I EM; 9.60 A; BC=1-233 # PDB 4V7S X-ray; 3.25 A; AC/CC=2-207 # PDB 4V7T X-ray; 3.19 A; AC/CC=2-207 # PDB 4V7U X-ray; 3.10 A; AC/CC=2-207 # PDB 4V7V X-ray; 3.29 A; AC/CC=2-207 # PDB 4V85 X-ray; 3.20 A; C=1-233 # PDB 4V89 X-ray; 3.70 A; AC=1-233 # PDB 4V9C X-ray; 3.30 A; AC/CC=1-233 # PDB 4V9D X-ray; 3.00 A; AC/BC=2-207 # PDB 4V9O X-ray; 2.90 A; BC/DC/FC/HC=1-233 # PDB 4V9P X-ray; 2.90 A; BC/DC/FC/HC=1-233 # PDB 4WF1 X-ray; 3.09 A; AC/CC=2-207 # PDB 4WOI X-ray; 3.00 A; AC/DC=1-233 # PDB 4WWW X-ray; 3.10 A; QC/XC=2-207 # PDB 4YBB X-ray; 2.10 A; AC/BC=2-207 # PDB 5AFI EM; 2.90 A; c=1-233 # PDB 5IQR EM; 3.00 A; h=1-233 # PDB 5IT8 X-ray; 3.12 A; AC/BC=2-207 # PDB 5J5B X-ray; 2.80 A; AC/BC=2-207 # PDB 5J7L X-ray; 3.00 A; AC/BC=2-207 # PDB 5J88 X-ray; 3.32 A; AC/BC=2-207 # PDB 5J8A X-ray; 3.10 A; AC/BC=2-207 # PDB 5J91 X-ray; 2.96 A; AC/BC=2-207 # PDB 5JC9 X-ray; 3.03 A; AC/BC=2-207 # PDB 5JTE EM; 3.60 A; AC=1-233 # PDB 5JU8 EM; 3.60 A; AC=1-233 # PDB 5KCR EM; 3.60 A; 1c=1-233 # PDB 5KCS EM; 3.90 A; 1c=1-233 # PDB 5KPS EM; 3.90 A; 8=1-233 # PDB 5KPV EM; 4.10 A; 7=1-233 # PDB 5KPW EM; 3.90 A; 7=1-233 # PDB 5KPX EM; 3.90 A; 7=1-233 # PDB 5L3P EM; 3.70 A; c=1-233 # PIR H23129 R3EC3 # PROSITE PS00548 RIBOSOMAL_S3 # PROSITE PS50823 KH_TYPE_2 # Pfam PF07650 KH_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RS3_ECOLI 30S ribosomal protein S3 # RefSeq NP_417773 NC_000913.3 # RefSeq WP_000529945 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein S3P family. {ECO 0000305}. # SIMILARITY Contains 1 KH type-2 domain. {ECO 0000305}. # SMART SM00322 KH # SUBUNIT Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14 (By similarity). With proteins S4 and S5 encircles the mRNA as it enters the ribosome, which may play a role in mRNA helicase processivity. Some nascent polypeptide chains are able to cross-link to this protein in situ. {ECO 0000250}. # SUPFAM SSF54814 SSF54814 # SUPFAM SSF54821 SSF54821 # TIGRFAMs TIGR01009 rpsC_bact # eggNOG COG0092 LUCA # eggNOG ENOG4105CKE Bacteria BLAST swissprot:RS3_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RS3_ECOLI BioCyc ECOL316407:JW3276-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3276-MONOMER BioCyc EcoCyc:EG10902-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10902-MONOMER BioCyc MetaCyc:EG10902-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10902-MONOMER COG COG0092 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0092 DIP DIP-35807N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35807N DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1016/0014-5793(79)80531-1 http://dx.doi.org/10.1016/0014-5793(79)80531-1 DOI 10.1016/S0092-8674(03)00427-6 http://dx.doi.org/10.1016/S0092-8674(03)00427-6 DOI 10.1016/j.cell.2004.11.042 http://dx.doi.org/10.1016/j.cell.2004.11.042 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb841 http://dx.doi.org/10.1038/nsb841 DOI 10.1046/j.1432-1327.1998.2550409.x http://dx.doi.org/10.1046/j.1432-1327.1998.2550409.x DOI 10.1093/nar/13.12.4521 http://dx.doi.org/10.1093/nar/13.12.4521 DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB00759 http://www.drugbank.ca/drugs/DB00759 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X02613 http://www.ebi.ac.uk/ena/data/view/X02613 EchoBASE EB0895 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0895 EcoGene EG10902 http://www.ecogene.org/geneInfo.php?eg_id=EG10902 EnsemblBacteria AAC76339 http://www.ensemblgenomes.org/id/AAC76339 EnsemblBacteria AAC76339 http://www.ensemblgenomes.org/id/AAC76339 EnsemblBacteria BAE77977 http://www.ensemblgenomes.org/id/BAE77977 EnsemblBacteria BAE77977 http://www.ensemblgenomes.org/id/BAE77977 EnsemblBacteria BAE77977 http://www.ensemblgenomes.org/id/BAE77977 EnsemblBacteria b3314 http://www.ensemblgenomes.org/id/b3314 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0022627 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022627 GO_function GO:0003729 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003729 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003729 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003729 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 Gene3D 3.30.1140.32 http://www.cathdb.info/version/latest/superfamily/3.30.1140.32 Gene3D 3.30.300.20 http://www.cathdb.info/version/latest/superfamily/3.30.300.20 GeneID 23846857 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23846857 GeneID 947814 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947814 HAMAP MF_01309_B http://hamap.expasy.org/unirule/MF_01309_B HOGENOM HOG000210610 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000210610&db=HOGENOM6 InParanoid P0A7V3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7V3 IntAct P0A7V3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7V3* InterPro IPR001351 http://www.ebi.ac.uk/interpro/entry/IPR001351 InterPro IPR004044 http://www.ebi.ac.uk/interpro/entry/IPR004044 InterPro IPR004087 http://www.ebi.ac.uk/interpro/entry/IPR004087 InterPro IPR005704 http://www.ebi.ac.uk/interpro/entry/IPR005704 InterPro IPR009019 http://www.ebi.ac.uk/interpro/entry/IPR009019 InterPro IPR015946 http://www.ebi.ac.uk/interpro/entry/IPR015946 InterPro IPR018280 http://www.ebi.ac.uk/interpro/entry/IPR018280 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW3276 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3276 KEGG_Gene eco:b3314 http://www.genome.jp/dbget-bin/www_bget?eco:b3314 KEGG_Orthology KO:K02982 http://www.genome.jp/dbget-bin/www_bget?KO:K02982 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 MINT MINT-6478122 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-6478122 OMA KTNPIGN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KTNPIGN PDB 1M5G http://www.ebi.ac.uk/pdbe-srv/view/entry/1M5G PDB 2YKR http://www.ebi.ac.uk/pdbe-srv/view/entry/2YKR PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 4A2I http://www.ebi.ac.uk/pdbe-srv/view/entry/4A2I PDB 4ADV http://www.ebi.ac.uk/pdbe-srv/view/entry/4ADV PDB 4ODQ http://www.ebi.ac.uk/pdbe-srv/view/entry/4ODQ PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4V47 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V47 PDB 4V48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V48 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 1M5G http://www.ebi.ac.uk/pdbsum/1M5G PDBsum 2YKR http://www.ebi.ac.uk/pdbsum/2YKR PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 4A2I http://www.ebi.ac.uk/pdbsum/4A2I PDBsum 4ADV http://www.ebi.ac.uk/pdbsum/4ADV PDBsum 4ODQ http://www.ebi.ac.uk/pdbsum/4ODQ PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4V47 http://www.ebi.ac.uk/pdbsum/4V47 PDBsum 4V48 http://www.ebi.ac.uk/pdbsum/4V48 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PROSITE PS00548 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00548 PROSITE PS50823 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50823 PSORT swissprot:RS3_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RS3_ECOLI PSORT-B swissprot:RS3_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RS3_ECOLI PSORT2 swissprot:RS3_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RS3_ECOLI Pfam PF07650 http://pfam.xfam.org/family/PF07650 Phobius swissprot:RS3_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RS3_ECOLI PhylomeDB P0A7V3 http://phylomedb.org/?seqid=P0A7V3 ProteinModelPortal P0A7V3 http://www.proteinmodelportal.org/query/uniprot/P0A7V3 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 12244297 http://www.ncbi.nlm.nih.gov/pubmed/12244297 PubMed 12809609 http://www.ncbi.nlm.nih.gov/pubmed/12809609 PubMed 15652481 http://www.ncbi.nlm.nih.gov/pubmed/15652481 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 387449 http://www.ncbi.nlm.nih.gov/pubmed/387449 PubMed 3892488 http://www.ncbi.nlm.nih.gov/pubmed/3892488 PubMed 7556101 http://www.ncbi.nlm.nih.gov/pubmed/7556101 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9716382 http://www.ncbi.nlm.nih.gov/pubmed/9716382 RefSeq NP_417773 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417773 RefSeq WP_000529945 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000529945 SMART SM00322 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00322 SMR P0A7V3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7V3 STRING 511145.b3314 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3314&targetmode=cogs STRING COG0092 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0092&targetmode=cogs SUPFAM SSF54814 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54814 SUPFAM SSF54821 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54821 TIGRFAMs TIGR01009 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01009 UniProtKB RS3_ECOLI http://www.uniprot.org/uniprot/RS3_ECOLI UniProtKB-AC P0A7V3 http://www.uniprot.org/uniprot/P0A7V3 charge swissprot:RS3_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RS3_ECOLI eggNOG COG0092 http://eggnogapi.embl.de/nog_data/html/tree/COG0092 eggNOG ENOG4105CKE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CKE epestfind swissprot:RS3_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RS3_ECOLI garnier swissprot:RS3_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RS3_ECOLI helixturnhelix swissprot:RS3_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RS3_ECOLI hmoment swissprot:RS3_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RS3_ECOLI iep swissprot:RS3_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RS3_ECOLI inforesidue swissprot:RS3_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RS3_ECOLI octanol swissprot:RS3_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RS3_ECOLI pepcoil swissprot:RS3_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RS3_ECOLI pepdigest swissprot:RS3_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RS3_ECOLI pepinfo swissprot:RS3_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RS3_ECOLI pepnet swissprot:RS3_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RS3_ECOLI pepstats swissprot:RS3_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RS3_ECOLI pepwheel swissprot:RS3_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RS3_ECOLI pepwindow swissprot:RS3_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RS3_ECOLI sigcleave swissprot:RS3_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RS3_ECOLI ## Database ID URL or Descriptions # BioGrid 4262452 36 # EcoGene EG12832 yhdU # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # InterPro IPR022540 DUF2556 # Organism YHDU_ECOLI Escherichia coli (strain K12) # PATRIC 32121956 VBIEscCol129921_3362 # PIR A65119 A65119 # Pfam PF10831 DUF2556 # ProDom PD052549 DUF2556 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHDU_ECOLI Uncharacterized protein YhdU # RefSeq NP_417729 NC_000913.3 # RefSeq WP_001295275 NZ_LN832404.1 # SUBCELLULAR LOCATION YHDU_ECOLI Membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. # eggNOG ENOG41061ME Bacteria # eggNOG ENOG4112BHE LUCA BLAST swissprot:YHDU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHDU_ECOLI BioCyc ECOL316407:JW3231-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3231-MONOMER BioCyc EcoCyc:G7694-MONOMER http://biocyc.org/getid?id=EcoCyc:G7694-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2681 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2681 EcoGene EG12832 http://www.ecogene.org/geneInfo.php?eg_id=EG12832 EnsemblBacteria AAC76295 http://www.ensemblgenomes.org/id/AAC76295 EnsemblBacteria AAC76295 http://www.ensemblgenomes.org/id/AAC76295 EnsemblBacteria BAE77304 http://www.ensemblgenomes.org/id/BAE77304 EnsemblBacteria BAE77304 http://www.ensemblgenomes.org/id/BAE77304 EnsemblBacteria BAE77304 http://www.ensemblgenomes.org/id/BAE77304 EnsemblBacteria b3263 http://www.ensemblgenomes.org/id/b3263 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GeneID 947700 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947700 HOGENOM HOG000268027 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000268027&db=HOGENOM6 InterPro IPR022540 http://www.ebi.ac.uk/interpro/entry/IPR022540 KEGG_Gene ecj:JW3231 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3231 KEGG_Gene eco:b3263 http://www.genome.jp/dbget-bin/www_bget?eco:b3263 OMA STETDKC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=STETDKC PSORT swissprot:YHDU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHDU_ECOLI PSORT-B swissprot:YHDU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHDU_ECOLI PSORT2 swissprot:YHDU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHDU_ECOLI Pfam PF10831 http://pfam.xfam.org/family/PF10831 Phobius swissprot:YHDU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHDU_ECOLI ProteinModelPortal P64619 http://www.proteinmodelportal.org/query/uniprot/P64619 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417729 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417729 RefSeq WP_001295275 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295275 STRING 511145.b3263 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3263&targetmode=cogs UniProtKB YHDU_ECOLI http://www.uniprot.org/uniprot/YHDU_ECOLI UniProtKB-AC P64619 http://www.uniprot.org/uniprot/P64619 charge swissprot:YHDU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHDU_ECOLI eggNOG ENOG41061ME http://eggnogapi.embl.de/nog_data/html/tree/ENOG41061ME eggNOG ENOG4112BHE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4112BHE epestfind swissprot:YHDU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHDU_ECOLI garnier swissprot:YHDU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHDU_ECOLI helixturnhelix swissprot:YHDU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHDU_ECOLI hmoment swissprot:YHDU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHDU_ECOLI iep swissprot:YHDU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHDU_ECOLI inforesidue swissprot:YHDU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHDU_ECOLI octanol swissprot:YHDU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHDU_ECOLI pepcoil swissprot:YHDU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHDU_ECOLI pepdigest swissprot:YHDU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHDU_ECOLI pepinfo swissprot:YHDU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHDU_ECOLI pepnet swissprot:YHDU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHDU_ECOLI pepstats swissprot:YHDU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHDU_ECOLI pepwheel swissprot:YHDU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHDU_ECOLI pepwindow swissprot:YHDU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHDU_ECOLI sigcleave swissprot:YHDU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHDU_ECOLI ## Database ID URL or Descriptions # BioGrid 4263140 265 # CDD cd06174 MFS # EcoGene EG12455 lplT # FUNCTION LPLT_ECOLI Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell. {ECO 0000269|PubMed 15661733}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0051978 lysophospholipid transporter activity; IMP:EcoCyc. # GO_process GO:0051977 lysophospholipid transport; IMP:EcoCyc. # GO_process GO:0055085 transmembrane transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # HAMAP MF_01585 MFS_LplT # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # InterPro IPR023727 LysoPLipid__transptr_LplT # KEGG_Brite ko02000 Transporters # Organism LPLT_ECOLI Escherichia coli (strain K12) # PATRIC 32121088 VBIEscCol129921_2933 # PIR D65066 D65066 # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LPLT_ECOLI Lysophospholipid transporter LplT # RefSeq NP_417312 NC_000913.3 # RefSeq WP_000004616 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=L14681; Type=Frameshift; Positions=75, 89; Evidence={ECO 0000305}; # SIMILARITY Belongs to the major facilitator superfamily. LplT (TC 2.A.1.42) family. {ECO 0000305}. # SUBCELLULAR LOCATION LPLT_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.42 the major facilitator superfamily (mfs) # eggNOG ENOG4107S74 Bacteria # eggNOG ENOG410XQW5 LUCA BLAST swissprot:LPLT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LPLT_ECOLI BioCyc ECOL316407:JW2803-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2803-MONOMER BioCyc EcoCyc:EG12455-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12455-MONOMER BioCyc MetaCyc:EG12455-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12455-MONOMER COG COG0477 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0477 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M414368200 http://dx.doi.org/10.1074/jbc.M414368200 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L14681 http://www.ebi.ac.uk/ena/data/view/L14681 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 EchoBASE EB2349 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2349 EcoGene EG12455 http://www.ecogene.org/geneInfo.php?eg_id=EG12455 EnsemblBacteria AAC75874 http://www.ensemblgenomes.org/id/AAC75874 EnsemblBacteria AAC75874 http://www.ensemblgenomes.org/id/AAC75874 EnsemblBacteria BAE76904 http://www.ensemblgenomes.org/id/BAE76904 EnsemblBacteria BAE76904 http://www.ensemblgenomes.org/id/BAE76904 EnsemblBacteria BAE76904 http://www.ensemblgenomes.org/id/BAE76904 EnsemblBacteria b2835 http://www.ensemblgenomes.org/id/b2835 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0051978 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051978 GO_process GO:0051977 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051977 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 947317 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947317 HAMAP MF_01585 http://hamap.expasy.org/unirule/MF_01585 HOGENOM HOG000261823 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261823&db=HOGENOM6 InParanoid P39196 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39196 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 InterPro IPR023727 http://www.ebi.ac.uk/interpro/entry/IPR023727 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2803 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2803 KEGG_Gene eco:b2835 http://www.genome.jp/dbget-bin/www_bget?eco:b2835 KEGG_Orthology KO:K08227 http://www.genome.jp/dbget-bin/www_bget?KO:K08227 OMA LMAFYTK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LMAFYTK PSORT swissprot:LPLT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LPLT_ECOLI PSORT-B swissprot:LPLT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LPLT_ECOLI PSORT2 swissprot:LPLT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LPLT_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:LPLT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LPLT_ECOLI PhylomeDB P39196 http://phylomedb.org/?seqid=P39196 ProteinModelPortal P39196 http://www.proteinmodelportal.org/query/uniprot/P39196 PubMed 15661733 http://www.ncbi.nlm.nih.gov/pubmed/15661733 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8300626 http://www.ncbi.nlm.nih.gov/pubmed/8300626 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417312 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417312 RefSeq WP_000004616 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000004616 STRING 511145.b2835 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2835&targetmode=cogs STRING COG0477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0477&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.42 http://www.tcdb.org/search/result.php?tc=2.A.1.42 UniProtKB LPLT_ECOLI http://www.uniprot.org/uniprot/LPLT_ECOLI UniProtKB-AC P39196 http://www.uniprot.org/uniprot/P39196 charge swissprot:LPLT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LPLT_ECOLI eggNOG ENOG4107S74 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107S74 eggNOG ENOG410XQW5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQW5 epestfind swissprot:LPLT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LPLT_ECOLI garnier swissprot:LPLT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LPLT_ECOLI helixturnhelix swissprot:LPLT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LPLT_ECOLI hmoment swissprot:LPLT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LPLT_ECOLI iep swissprot:LPLT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LPLT_ECOLI inforesidue swissprot:LPLT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LPLT_ECOLI octanol swissprot:LPLT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LPLT_ECOLI pepcoil swissprot:LPLT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LPLT_ECOLI pepdigest swissprot:LPLT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LPLT_ECOLI pepinfo swissprot:LPLT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LPLT_ECOLI pepnet swissprot:LPLT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LPLT_ECOLI pepstats swissprot:LPLT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LPLT_ECOLI pepwheel swissprot:LPLT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LPLT_ECOLI pepwindow swissprot:LPLT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LPLT_ECOLI sigcleave swissprot:LPLT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LPLT_ECOLI ## Database ID URL or Descriptions # BioGrid 4260035 14 # CDD cd04458 CSP_CDS # EcoGene EG14281 cspH # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # InterPro IPR002059 CSP_DNA-bd # InterPro IPR011129 Cold_shock_prot # InterPro IPR012156 Cold_shock_CspA # InterPro IPR012340 NA-bd_OB-fold # InterPro IPR019844 Cold-shock_CS # KEGG_Brite ko03000 Transcription factors # Organism CSPH_ECOLI Escherichia coli (strain K12) # PATRIC 32117203 VBIEscCol129921_1025 # PIR C64840 C64840 # PIRSF PIRSF002599 Cold_shock_A # PROSITE PS00352 COLD_SHOCK # Pfam PF00313 CSD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CSPH_ECOLI Cold shock-like protein CspH # RefSeq NP_415509 NC_000913.3 # RefSeq WP_000087763 NZ_LN832404.1 # SIMILARITY Contains 1 CSD (cold-shock) domain. {ECO 0000305}. # SMART SM00357 CSP # SUBCELLULAR LOCATION CSPH_ECOLI Cytoplasm {ECO 0000250}. # SUPFAM SSF50249 SSF50249 # eggNOG ENOG41060EU Bacteria # eggNOG ENOG4111W5C LUCA BLAST swissprot:CSPH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CSPH_ECOLI BioCyc ECOL316407:JW5134-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5134-MONOMER BioCyc EcoCyc:G6510-MONOMER http://biocyc.org/getid?id=EcoCyc:G6510-MONOMER COG COG1278 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1278 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/sj.jim.2900463 http://dx.doi.org/10.1038/sj.jim.2900463 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AF003591 http://www.ebi.ac.uk/ena/data/view/AF003591 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4029 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4029 EcoGene EG14281 http://www.ecogene.org/geneInfo.php?eg_id=EG14281 EnsemblBacteria AAC74074 http://www.ensemblgenomes.org/id/AAC74074 EnsemblBacteria AAC74074 http://www.ensemblgenomes.org/id/AAC74074 EnsemblBacteria BAA35755 http://www.ensemblgenomes.org/id/BAA35755 EnsemblBacteria BAA35755 http://www.ensemblgenomes.org/id/BAA35755 EnsemblBacteria BAA35755 http://www.ensemblgenomes.org/id/BAA35755 EnsemblBacteria b0989 http://www.ensemblgenomes.org/id/b0989 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 945590 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945590 HOGENOM HOG000070674 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000070674&db=HOGENOM6 InParanoid P0A982 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A982 InterPro IPR002059 http://www.ebi.ac.uk/interpro/entry/IPR002059 InterPro IPR011129 http://www.ebi.ac.uk/interpro/entry/IPR011129 InterPro IPR012156 http://www.ebi.ac.uk/interpro/entry/IPR012156 InterPro IPR012340 http://www.ebi.ac.uk/interpro/entry/IPR012340 InterPro IPR019844 http://www.ebi.ac.uk/interpro/entry/IPR019844 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW5134 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5134 KEGG_Gene eco:b0989 http://www.genome.jp/dbget-bin/www_bget?eco:b0989 KEGG_Orthology KO:K03704 http://www.genome.jp/dbget-bin/www_bget?KO:K03704 OMA IEFCRIN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IEFCRIN PROSITE PS00352 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00352 PSORT swissprot:CSPH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CSPH_ECOLI PSORT-B swissprot:CSPH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CSPH_ECOLI PSORT2 swissprot:CSPH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CSPH_ECOLI Pfam PF00313 http://pfam.xfam.org/family/PF00313 Phobius swissprot:CSPH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CSPH_ECOLI PhylomeDB P0A982 http://phylomedb.org/?seqid=P0A982 ProteinModelPortal P0A982 http://www.proteinmodelportal.org/query/uniprot/P0A982 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9439003 http://www.ncbi.nlm.nih.gov/pubmed/9439003 RefSeq NP_415509 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415509 RefSeq WP_000087763 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000087763 SMART SM00357 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00357 SMR P0A982 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A982 STRING 511145.b0989 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0989&targetmode=cogs STRING COG1278 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1278&targetmode=cogs SUPFAM SSF50249 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50249 UniProtKB CSPH_ECOLI http://www.uniprot.org/uniprot/CSPH_ECOLI UniProtKB-AC P0A982 http://www.uniprot.org/uniprot/P0A982 charge swissprot:CSPH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CSPH_ECOLI eggNOG ENOG41060EU http://eggnogapi.embl.de/nog_data/html/tree/ENOG41060EU eggNOG ENOG4111W5C http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111W5C epestfind swissprot:CSPH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CSPH_ECOLI garnier swissprot:CSPH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CSPH_ECOLI helixturnhelix swissprot:CSPH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CSPH_ECOLI hmoment swissprot:CSPH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CSPH_ECOLI iep swissprot:CSPH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CSPH_ECOLI inforesidue swissprot:CSPH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CSPH_ECOLI octanol swissprot:CSPH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CSPH_ECOLI pepcoil swissprot:CSPH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CSPH_ECOLI pepdigest swissprot:CSPH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CSPH_ECOLI pepinfo swissprot:CSPH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CSPH_ECOLI pepnet swissprot:CSPH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CSPH_ECOLI pepstats swissprot:CSPH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CSPH_ECOLI pepwheel swissprot:CSPH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CSPH_ECOLI pepwindow swissprot:CSPH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CSPH_ECOLI sigcleave swissprot:CSPH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CSPH_ECOLI ## Database ID URL or Descriptions # AltName EIIB-Gat {ECO:0000303|PubMed 7772602} # AltName Galactitol-specific phosphotransferase enzyme IIA component {ECO:0000303|PubMed 7772602} # BIOPHYSICOCHEMICAL PROPERTIES PTKA_ECOLI Kinetic parameters KM=4.4 uM for D-galactitol {ECO 0000269|PubMed 1100608}; KM=800 uM for D-glucitol {ECO 0000269|PubMed 1100608}; Vmax=3.2 nmol/min/mg enzyme with D-galactitol as substrate {ECO 0000269|PubMed 1100608}; Vmax=3.2 nmol/min/mg enzyme with D-glucitol as substrate {ECO 0000269|PubMed 1100608}; # CATALYTIC ACTIVITY [Protein]-N(pi)-phospho-L-histidine + galactitol(Side 1) = [protein]-L-histidine + galactitol 1- phosphate(Side 2). {ECO:0000269|PubMed 1100608}. # CAUTION In strain W3110, the sequence is interrupted by the insertion of an IS5 element between positions 69 and 70. {ECO 0000305}. # DOMAIN PTKA_ECOLI The EIIA domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the EIIB domain. {ECO 0000255|PROSITE-ProRule PRU00417}. # EcoGene EG12414 gatA # FUNCTION PTKA_ECOLI The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. The enzyme II complex composed of GatA, GatB and GatC is involved in galactitol transport. It can also use D-glucitol. {ECO 0000269|PubMed 1100608, ECO 0000269|PubMed 8955298}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0016301 kinase activity; IEA:UniProtKB-KW. # GO_function GO:0090584 protein-phosphocysteine-galactitol-phosphotransferase system transporter activity; IDA:EcoCyc. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IDA:EcoCyc. # GO_process GO:0015796 galactitol transport; IDA:EcoCyc. # GO_process GO:0019402 galactitol metabolic process; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006810 transport # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.930.10 -; 1. # INDUCTION Constitutively expressed. {ECO:0000269|PubMed 8955298}. # IntAct P69828 3 # InterPro IPR002178 PTS_EIIA_type-2_dom # InterPro IPR016152 PTrfase/Anion_transptr # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00279 PTS system, galactitol-specific II component # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko00052 Galactose metabolism # KEGG_Pathway ko02060 Phosphotransferase system (PTS) # Organism PTKA_ECOLI Escherichia coli (strain K12) # PATRIC 32119521 VBIEscCol129921_2171 # PIR E64976 E64976 # PIR S55903 S55903 # PROSITE PS51094 PTS_EIIA_TYPE_2 # Pfam PF00359 PTS_EIIA_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PTS system galactitol-specific EIIA component {ECO:0000303|PubMed 7772602} # RefSeq NP_416597 NC_000913.3 # RefSeq WP_000182899 NZ_LN832404.1 # SIMILARITY Contains 1 PTS EIIA type-2 domain. {ECO:0000255|PROSITE-ProRule PRU00417}. # SUBCELLULAR LOCATION PTKA_ECOLI Cytoplasm {ECO 0000305|PubMed 8955298}. # SUBUNIT Forms a complex with one each of subunit of GatA, GatB and 2 subunits of GatC. {ECO:0000269|PubMed 16079137}. # SUPFAM SSF55804 SSF55804 # TCDB 4.A.5.1 the pts galactitol (gat) family # eggNOG COG1762 LUCA # eggNOG ENOG41082GB Bacteria BLAST swissprot:PTKA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTKA_ECOLI BioCyc ECOL316407:JW2078-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2078-MONOMER BioCyc ECOL316407:JW2081-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2081-MONOMER BioCyc EcoCyc:GATA-MONOMER http://biocyc.org/getid?id=EcoCyc:GATA-MONOMER BioCyc MetaCyc:GATA-MONOMER http://biocyc.org/getid?id=MetaCyc:GATA-MONOMER COG COG1762 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1762 DIP DIP-47900N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47900N DOI 10.1016/0167-4781(95)00053-J http://dx.doi.org/10.1016/0167-4781(95)00053-J DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.200 {ECO:0000269|PubMed:1100608} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.200 {ECO:0000269|PubMed:1100608} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X79837 http://www.ebi.ac.uk/ena/data/view/X79837 ENZYME 2.7.1.200 {ECO:0000269|PubMed:1100608} http://enzyme.expasy.org/EC/2.7.1.200 {ECO:0000269|PubMed:1100608} EchoBASE EB2313 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2313 EcoGene EG12414 http://www.ecogene.org/geneInfo.php?eg_id=EG12414 EnsemblBacteria AAC75155 http://www.ensemblgenomes.org/id/AAC75155 EnsemblBacteria AAC75155 http://www.ensemblgenomes.org/id/AAC75155 EnsemblBacteria BAA15957 http://www.ensemblgenomes.org/id/BAA15957 EnsemblBacteria BAA15957 http://www.ensemblgenomes.org/id/BAA15957 EnsemblBacteria BAA15957 http://www.ensemblgenomes.org/id/BAA15957 EnsemblBacteria BAA15964 http://www.ensemblgenomes.org/id/BAA15964 EnsemblBacteria BAA15964 http://www.ensemblgenomes.org/id/BAA15964 EnsemblBacteria BAA15964 http://www.ensemblgenomes.org/id/BAA15964 EnsemblBacteria b2094 http://www.ensemblgenomes.org/id/b2094 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_function GO:0090584 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090584 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GO_process GO:0015796 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015796 GO_process GO:0019402 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019402 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.930.10 http://www.cathdb.info/version/latest/superfamily/3.40.930.10 GeneID 946633 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946633 HOGENOM HOG000122110 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122110&db=HOGENOM6 IntAct P69828 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69828* IntEnz 2.7.1.200 {ECO:0000269|PubMed:1100608} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.200 {ECO:0000269|PubMed:1100608} InterPro IPR002178 http://www.ebi.ac.uk/interpro/entry/IPR002178 InterPro IPR016152 http://www.ebi.ac.uk/interpro/entry/IPR016152 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2078 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2078 KEGG_Gene ecj:JW2081 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2081 KEGG_Gene eco:b2094 http://www.genome.jp/dbget-bin/www_bget?eco:b2094 KEGG_Orthology KO:K02773 http://www.genome.jp/dbget-bin/www_bget?KO:K02773 KEGG_Pathway ko00052 http://www.genome.jp/kegg-bin/show_pathway?ko00052 KEGG_Pathway ko02060 http://www.genome.jp/kegg-bin/show_pathway?ko02060 KEGG_Reaction rn:R05570 http://www.genome.jp/dbget-bin/www_bget?rn:R05570 MINT MINT-1300341 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1300341 OMA ENMAVAI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ENMAVAI PROSITE PS51094 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51094 PSORT swissprot:PTKA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTKA_ECOLI PSORT-B swissprot:PTKA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTKA_ECOLI PSORT2 swissprot:PTKA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTKA_ECOLI Pfam PF00359 http://pfam.xfam.org/family/PF00359 Phobius swissprot:PTKA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTKA_ECOLI PhylomeDB P69828 http://phylomedb.org/?seqid=P69828 ProteinModelPortal P69828 http://www.proteinmodelportal.org/query/uniprot/P69828 PubMed 1100608 http://www.ncbi.nlm.nih.gov/pubmed/1100608 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7772602 http://www.ncbi.nlm.nih.gov/pubmed/7772602 PubMed 8955298 http://www.ncbi.nlm.nih.gov/pubmed/8955298 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416597 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416597 RefSeq WP_000182899 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000182899 SMR P69828 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69828 STRING 511145.b2094 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2094&targetmode=cogs STRING COG1762 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1762&targetmode=cogs SUPFAM SSF55804 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55804 TCDB 4.A.5.1 http://www.tcdb.org/search/result.php?tc=4.A.5.1 UniProtKB PTKA_ECOLI http://www.uniprot.org/uniprot/PTKA_ECOLI UniProtKB-AC P69828 http://www.uniprot.org/uniprot/P69828 charge swissprot:PTKA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTKA_ECOLI eggNOG COG1762 http://eggnogapi.embl.de/nog_data/html/tree/COG1762 eggNOG ENOG41082GB http://eggnogapi.embl.de/nog_data/html/tree/ENOG41082GB epestfind swissprot:PTKA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTKA_ECOLI garnier swissprot:PTKA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTKA_ECOLI helixturnhelix swissprot:PTKA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTKA_ECOLI hmoment swissprot:PTKA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTKA_ECOLI iep swissprot:PTKA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTKA_ECOLI inforesidue swissprot:PTKA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTKA_ECOLI octanol swissprot:PTKA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTKA_ECOLI pepcoil swissprot:PTKA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTKA_ECOLI pepdigest swissprot:PTKA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTKA_ECOLI pepinfo swissprot:PTKA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTKA_ECOLI pepnet swissprot:PTKA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTKA_ECOLI pepstats swissprot:PTKA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTKA_ECOLI pepwheel swissprot:PTKA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTKA_ECOLI pepwindow swissprot:PTKA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTKA_ECOLI sigcleave swissprot:PTKA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTKA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262687 552 # EcoGene EG12471 yjeI # GO_function GO:0016491 oxidoreductase activity; IEA:InterPro. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006950 response to stress # Gene3D 3.50.50.60 -; 1. # InterPro IPR023753 FAD/NAD-binding_dom # InterPro IPR025294 DUF4156 # Organism YJEI_ECOLI Escherichia coli (strain K12) # PATRIC 32123857 VBIEscCol129921_4276 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF13698 DUF4156 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJEI_ECOLI Uncharacterized protein YjeI # RefSeq NP_418568 NC_000913.3 # RefSeq WP_000558209 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97043.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # eggNOG ENOG4108ZVF Bacteria # eggNOG ENOG4111NYT LUCA BLAST swissprot:YJEI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJEI_ECOLI BioCyc ECOL316407:JW5736-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5736-MONOMER BioCyc EcoCyc:G7834-MONOMER http://biocyc.org/getid?id=EcoCyc:G7834-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2364 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2364 EcoGene EG12471 http://www.ecogene.org/geneInfo.php?eg_id=EG12471 EnsemblBacteria AAC77104 http://www.ensemblgenomes.org/id/AAC77104 EnsemblBacteria AAC77104 http://www.ensemblgenomes.org/id/AAC77104 EnsemblBacteria BAE78146 http://www.ensemblgenomes.org/id/BAE78146 EnsemblBacteria BAE78146 http://www.ensemblgenomes.org/id/BAE78146 EnsemblBacteria BAE78146 http://www.ensemblgenomes.org/id/BAE78146 EnsemblBacteria b4144 http://www.ensemblgenomes.org/id/b4144 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 GeneID 948664 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948664 HOGENOM HOG000286601 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000286601&db=HOGENOM6 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 InterPro IPR025294 http://www.ebi.ac.uk/interpro/entry/IPR025294 KEGG_Gene ecj:JW5736 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5736 KEGG_Gene eco:b4144 http://www.genome.jp/dbget-bin/www_bget?eco:b4144 OMA DSKMVGQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DSKMVGQ PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YJEI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJEI_ECOLI PSORT-B swissprot:YJEI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJEI_ECOLI PSORT2 swissprot:YJEI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJEI_ECOLI Pfam PF13698 http://pfam.xfam.org/family/PF13698 Phobius swissprot:YJEI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJEI_ECOLI ProteinModelPortal P0AF70 http://www.proteinmodelportal.org/query/uniprot/P0AF70 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418568 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418568 RefSeq WP_000558209 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000558209 STRING 511145.b4144 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4144&targetmode=cogs UniProtKB YJEI_ECOLI http://www.uniprot.org/uniprot/YJEI_ECOLI UniProtKB-AC P0AF70 http://www.uniprot.org/uniprot/P0AF70 charge swissprot:YJEI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJEI_ECOLI eggNOG ENOG4108ZVF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZVF eggNOG ENOG4111NYT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111NYT epestfind swissprot:YJEI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJEI_ECOLI garnier swissprot:YJEI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJEI_ECOLI helixturnhelix swissprot:YJEI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJEI_ECOLI hmoment swissprot:YJEI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJEI_ECOLI iep swissprot:YJEI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJEI_ECOLI inforesidue swissprot:YJEI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJEI_ECOLI octanol swissprot:YJEI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJEI_ECOLI pepcoil swissprot:YJEI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJEI_ECOLI pepdigest swissprot:YJEI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJEI_ECOLI pepinfo swissprot:YJEI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJEI_ECOLI pepnet swissprot:YJEI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJEI_ECOLI pepstats swissprot:YJEI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJEI_ECOLI pepwheel swissprot:YJEI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJEI_ECOLI pepwindow swissprot:YJEI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJEI_ECOLI sigcleave swissprot:YJEI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJEI_ECOLI ## Database ID URL or Descriptions # BioGrid 4259648 14 # DISRUPTION PHENOTYPE No visible phenotype. {ECO:0000269|PubMed 16573693}. # EcoGene EG13258 qmcA # FUNCTION QMCA_ECOLI Identified as a multi-copy suppressor of an FtsH/HtpX protease double disruption mutant. May play a role in the quality control of integral membrane proteins. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # IntAct P0AA53 3 # InterPro IPR001107 Band_7 # InterPro IPR001972 Stomatin_fam # InterPro IPR018080 Band_7/stomatin-like_CS # InterPro IPR032435 Band_7_C # Organism QMCA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10264 PTHR10264 # PATRIC 32116137 VBIEscCol129921_0510 # PIR H64779 H64779 # PRINTS PR00721 STOMATIN # PROSITE PS01270 BAND_7 # Pfam PF01145 Band_7 # Pfam PF16200 Band_7_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName QMCA_ECOLI Protein QmcA # RefSeq NP_415022 NC_000913.3 # RefSeq WP_000904502 NZ_LN832404.1 # SIMILARITY Belongs to the band 7/mec-2 family. {ECO 0000305}. # SMART SM00244 PHB # SUBCELLULAR LOCATION QMCA_ECOLI Cell inner membrane {ECO 0000269|PubMed 16573693}; Single-pass type I membrane protein {ECO 0000269|PubMed 16573693}. # SUBUNIT Forms oligomers. Probably interacts weakly with FtsH. {ECO:0000269|PubMed 16573693}. # SUPFAM SSF117892 SSF117892 # TCDB 8.A.21.2 the stomatin/podocin/band 7/nephrosis.2/spfh (stomatin) family # eggNOG COG0330 LUCA # eggNOG ENOG4107QX8 Bacteria BLAST swissprot:QMCA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:QMCA_ECOLI BioCyc ECOL316407:JW0478-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0478-MONOMER BioCyc EcoCyc:G6265-MONOMER http://biocyc.org/getid?id=EcoCyc:G6265-MONOMER DIP DIP-48137N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48137N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/jb/mvp071 http://dx.doi.org/10.1093/jb/mvp071 DOI 10.1111/j.1365-2958.2006.05104.x http://dx.doi.org/10.1111/j.1365-2958.2006.05104.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EchoBASE EB3046 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3046 EcoGene EG13258 http://www.ecogene.org/geneInfo.php?eg_id=EG13258 EnsemblBacteria AAC73591 http://www.ensemblgenomes.org/id/AAC73591 EnsemblBacteria AAC73591 http://www.ensemblgenomes.org/id/AAC73591 EnsemblBacteria BAE76268 http://www.ensemblgenomes.org/id/BAE76268 EnsemblBacteria BAE76268 http://www.ensemblgenomes.org/id/BAE76268 EnsemblBacteria BAE76268 http://www.ensemblgenomes.org/id/BAE76268 EnsemblBacteria b0489 http://www.ensemblgenomes.org/id/b0489 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 947257 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947257 HOGENOM HOG000217039 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000217039&db=HOGENOM6 InParanoid P0AA53 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AA53 IntAct P0AA53 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AA53* InterPro IPR001107 http://www.ebi.ac.uk/interpro/entry/IPR001107 InterPro IPR001972 http://www.ebi.ac.uk/interpro/entry/IPR001972 InterPro IPR018080 http://www.ebi.ac.uk/interpro/entry/IPR018080 InterPro IPR032435 http://www.ebi.ac.uk/interpro/entry/IPR032435 KEGG_Gene ecj:JW0478 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0478 KEGG_Gene eco:b0489 http://www.genome.jp/dbget-bin/www_bget?eco:b0489 OMA IVRPYER http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IVRPYER PANTHER PTHR10264 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10264 PRINTS PR00721 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00721 PROSITE PS01270 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01270 PSORT swissprot:QMCA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:QMCA_ECOLI PSORT-B swissprot:QMCA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:QMCA_ECOLI PSORT2 swissprot:QMCA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:QMCA_ECOLI Pfam PF01145 http://pfam.xfam.org/family/PF01145 Pfam PF16200 http://pfam.xfam.org/family/PF16200 Phobius swissprot:QMCA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:QMCA_ECOLI PhylomeDB P0AA53 http://phylomedb.org/?seqid=P0AA53 ProteinModelPortal P0AA53 http://www.proteinmodelportal.org/query/uniprot/P0AA53 PubMed 16573693 http://www.ncbi.nlm.nih.gov/pubmed/16573693 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19454621 http://www.ncbi.nlm.nih.gov/pubmed/19454621 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415022 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415022 RefSeq WP_000904502 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000904502 SMART SM00244 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00244 SMR P0AA53 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AA53 STRING 511145.b0489 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0489&targetmode=cogs SUPFAM SSF117892 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF117892 TCDB 8.A.21.2 http://www.tcdb.org/search/result.php?tc=8.A.21.2 UniProtKB QMCA_ECOLI http://www.uniprot.org/uniprot/QMCA_ECOLI UniProtKB-AC P0AA53 http://www.uniprot.org/uniprot/P0AA53 charge swissprot:QMCA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:QMCA_ECOLI eggNOG COG0330 http://eggnogapi.embl.de/nog_data/html/tree/COG0330 eggNOG ENOG4107QX8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QX8 epestfind swissprot:QMCA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:QMCA_ECOLI garnier swissprot:QMCA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:QMCA_ECOLI helixturnhelix swissprot:QMCA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:QMCA_ECOLI hmoment swissprot:QMCA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:QMCA_ECOLI iep swissprot:QMCA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:QMCA_ECOLI inforesidue swissprot:QMCA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:QMCA_ECOLI octanol swissprot:QMCA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:QMCA_ECOLI pepcoil swissprot:QMCA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:QMCA_ECOLI pepdigest swissprot:QMCA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:QMCA_ECOLI pepinfo swissprot:QMCA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:QMCA_ECOLI pepnet swissprot:QMCA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:QMCA_ECOLI pepstats swissprot:QMCA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:QMCA_ECOLI pepwheel swissprot:QMCA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:QMCA_ECOLI pepwindow swissprot:QMCA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:QMCA_ECOLI sigcleave swissprot:QMCA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:QMCA_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES RHMD_ECOLI Kinetic parameters KM=0.15 mM for L-rhamnonate {ECO 0000269|PubMed 18754693}; KM=2.0 mM for L-lyxonate {ECO 0000269|PubMed 18754693}; KM=0.15 mM for L-mannonate {ECO 0000269|PubMed 18754693}; Note=The catalytic efficiency observed with L-rhamnonate as substrate is 70- and 16-fold higher than that observed with L- lyxonate and L-mannonate, respectively.; # BRENDA 4.2.1.90 2165 # BioGrid 4261221 139 # CATALYTIC ACTIVITY RHMD_ECOLI L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H(2)O. # COFACTOR RHMD_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250}; Note=Binds 1 Mg(2+) ion per subunit. {ECO 0000250}; # EcoGene EG14085 rhmD # FUNCTION RHMD_ECOLI Catalyzes the dehydration of L-rhamnonate to 2-keto-3- deoxy-L-rhamnonate (KDR). Can also dehydrate L-lyxonate, L- mannonate and D-gulonate, although less efficiently, but not 2- keto-4-hydroxyheptane-1,7-dioate. {ECO 0000269|PubMed 18754693}. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0050032 L-rhamnonate dehydratase activity; IDA:EcoCyc. # GO_process GO:0009063 cellular amino acid catabolic process; IEA:InterPro. # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # Gene3D 3.20.20.120 -; 1. # Gene3D 3.30.390.10 -; 1. # HAMAP MF_01288 Rhamnon_dehydrat # IntAct P77215 11 # InterPro IPR001354 MR/MLE/MAL # InterPro IPR013341 Mandelate_racemase_N_dom # InterPro IPR013342 Mandelate_racemase_C # InterPro IPR018110 Mandel_Rmase/mucon_lact_enz_CS # InterPro IPR023444 L-Rhamnon_dehydrat # InterPro IPR029017 Enolase_N-like # InterPro IPR029065 Enolase_C-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00051 Fructose and mannose metabolism # MISCELLANEOUS RHMD_ECOLI Reaction proceeds via a syn dehydration. # Organism RHMD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR13794 PTHR13794 # PATRIC 32119857 VBIEscCol129921_2338 # PDB 2I5Q X-ray; 2.10 A; A/B=1-401 # PIR E64995 E64995 # PROSITE PS00908 MR_MLE_1 # Pfam PF02746 MR_MLE_N # Pfam PF13378 MR_MLE_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RHMD_ECOLI L-rhamnonate dehydratase # RefSeq NP_416750 NC_000913.3 # RefSeq WP_001319848 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA16071.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the mandelate racemase/muconate lactonizing enzyme family. RhamD subfamily. {ECO 0000305}. # SMART SM00922 MR_MLE # SUBUNIT Homooctamer; tetramer of dimers. {ECO:0000269|PubMed 18754693}. # SUPFAM SSF51604 SSF51604 # SUPFAM SSF54826 SSF54826 # eggNOG COG4948 LUCA # eggNOG ENOG4105CXK Bacteria BLAST swissprot:RHMD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RHMD_ECOLI BioCyc ECOL316407:JW2241-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2241-MONOMER BioCyc EcoCyc:G7160-MONOMER http://biocyc.org/getid?id=EcoCyc:G7160-MONOMER BioCyc MetaCyc:G7160-MONOMER http://biocyc.org/getid?id=MetaCyc:G7160-MONOMER COG COG4948 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4948 DIP DIP-11955N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11955N DOI 10.1021/bi800914r http://dx.doi.org/10.1021/bi800914r DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.1.90 http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.90 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 4.2.1.90 http://enzyme.expasy.org/EC/4.2.1.90 EchoBASE EB3838 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3838 EcoGene EG14085 http://www.ecogene.org/geneInfo.php?eg_id=EG14085 EnsemblBacteria AAC75307 http://www.ensemblgenomes.org/id/AAC75307 EnsemblBacteria AAC75307 http://www.ensemblgenomes.org/id/AAC75307 EnsemblBacteria BAA16071 http://www.ensemblgenomes.org/id/BAA16071 EnsemblBacteria BAA16071 http://www.ensemblgenomes.org/id/BAA16071 EnsemblBacteria BAA16071 http://www.ensemblgenomes.org/id/BAA16071 EnsemblBacteria b2247 http://www.ensemblgenomes.org/id/b2247 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0050032 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050032 GO_process GO:0009063 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009063 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 3.20.20.120 http://www.cathdb.info/version/latest/superfamily/3.20.20.120 Gene3D 3.30.390.10 http://www.cathdb.info/version/latest/superfamily/3.30.390.10 GeneID 945881 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945881 HAMAP MF_01288 http://hamap.expasy.org/unirule/MF_01288 HOGENOM HOG000113755 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000113755&db=HOGENOM6 InParanoid P77215 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77215 IntAct P77215 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77215* IntEnz 4.2.1.90 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.90 InterPro IPR001354 http://www.ebi.ac.uk/interpro/entry/IPR001354 InterPro IPR013341 http://www.ebi.ac.uk/interpro/entry/IPR013341 InterPro IPR013342 http://www.ebi.ac.uk/interpro/entry/IPR013342 InterPro IPR018110 http://www.ebi.ac.uk/interpro/entry/IPR018110 InterPro IPR023444 http://www.ebi.ac.uk/interpro/entry/IPR023444 InterPro IPR029017 http://www.ebi.ac.uk/interpro/entry/IPR029017 InterPro IPR029065 http://www.ebi.ac.uk/interpro/entry/IPR029065 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2241 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2241 KEGG_Gene eco:b2247 http://www.genome.jp/dbget-bin/www_bget?eco:b2247 KEGG_Orthology KO:K12661 http://www.genome.jp/dbget-bin/www_bget?KO:K12661 KEGG_Pathway ko00051 http://www.genome.jp/kegg-bin/show_pathway?ko00051 KEGG_Reaction rn:R03774 http://www.genome.jp/dbget-bin/www_bget?rn:R03774 PANTHER PTHR13794 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13794 PDB 2I5Q http://www.ebi.ac.uk/pdbe-srv/view/entry/2I5Q PDBsum 2I5Q http://www.ebi.ac.uk/pdbsum/2I5Q PROSITE PS00908 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00908 PSORT swissprot:RHMD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RHMD_ECOLI PSORT-B swissprot:RHMD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RHMD_ECOLI PSORT2 swissprot:RHMD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RHMD_ECOLI Pfam PF02746 http://pfam.xfam.org/family/PF02746 Pfam PF13378 http://pfam.xfam.org/family/PF13378 Phobius swissprot:RHMD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RHMD_ECOLI PhylomeDB P77215 http://phylomedb.org/?seqid=P77215 ProteinModelPortal P77215 http://www.proteinmodelportal.org/query/uniprot/P77215 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18754693 http://www.ncbi.nlm.nih.gov/pubmed/18754693 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416750 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416750 RefSeq WP_001319848 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001319848 SMART SM00922 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00922 SMR P77215 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77215 STRING 511145.b2247 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2247&targetmode=cogs STRING COG4948 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4948&targetmode=cogs SUPFAM SSF51604 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51604 SUPFAM SSF54826 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54826 UniProtKB RHMD_ECOLI http://www.uniprot.org/uniprot/RHMD_ECOLI UniProtKB-AC P77215 http://www.uniprot.org/uniprot/P77215 charge swissprot:RHMD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RHMD_ECOLI eggNOG COG4948 http://eggnogapi.embl.de/nog_data/html/tree/COG4948 eggNOG ENOG4105CXK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CXK epestfind swissprot:RHMD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RHMD_ECOLI garnier swissprot:RHMD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RHMD_ECOLI helixturnhelix swissprot:RHMD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RHMD_ECOLI hmoment swissprot:RHMD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RHMD_ECOLI iep swissprot:RHMD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RHMD_ECOLI inforesidue swissprot:RHMD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RHMD_ECOLI octanol swissprot:RHMD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RHMD_ECOLI pepcoil swissprot:RHMD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RHMD_ECOLI pepdigest swissprot:RHMD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RHMD_ECOLI pepinfo swissprot:RHMD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RHMD_ECOLI pepnet swissprot:RHMD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RHMD_ECOLI pepstats swissprot:RHMD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RHMD_ECOLI pepwheel swissprot:RHMD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RHMD_ECOLI pepwindow swissprot:RHMD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RHMD_ECOLI sigcleave swissprot:RHMD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RHMD_ECOLI ## Database ID URL or Descriptions # AltName NARG_ECOLI Nitrate reductase A subunit alpha # AltName NARG_ECOLI Quinol-nitrate oxidoreductase subunit alpha # BRENDA 1.7.5 2026 # BRENDA 1.7.99 2026 # BioGrid 4263271 19 # CATALYTIC ACTIVITY NARG_ECOLI Nitrite + acceptor = nitrate + reduced acceptor. # COFACTOR Name=Mo-bis(molybdopterin guanine dinucleotide); Xref=ChEBI:CHEBI 60539; Note=Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.; # COFACTOR Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI 49883; Note=Binds 1 [4Fe-4S] cluster per subunit.; # DOMAIN NARG_ECOLI Apoenzyme contains at least 2 NarJ-binding sites, one interfering with membrane anchoring and another being involved in molybdenum insertion. The first binding-site is a short peptide sequence near the N-terminus that contains a twin-arginine homologous motif. {ECO 0000269|PubMed 16286471, ECO 0000269|PubMed 16540088}. # EcoGene EG10638 narG # FUNCTION NARG_ECOLI The nitrate reductase enzyme complex allows E.coli to use nitrate as an electron acceptor during anaerobic growth. The alpha chain is the actual site of nitrate reduction. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_component GO:0031224 intrinsic component of membrane; IDA:EcoCyc. # GO_component GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane; IDA:EcoCyc. # GO_component GO:0044799 NarGHI complex; IDA:EcoCyc. # GO_function GO:0008940 nitrate reductase activity; IDA:EcoCyc. # GO_function GO:0009055 electron carrier activity; IDA:EcoCyc. # GO_function GO:0030151 molybdenum ion binding; IEA:InterPro. # GO_function GO:0043546 molybdopterin cofactor binding; IDA:EcoCyc. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IDA:EcoCyc. # GO_process GO:0009061 anaerobic respiration; IEP:EcoCyc. # GO_process GO:0042126 nitrate metabolic process; IMP:EcoCyc. # GO_process GO:0042128 nitrate assimilation; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0071941 nitrogen cycle metabolic process # INDUCTION NARG_ECOLI By nitrate. # INTERACTION NARG_ECOLI P11349 narH; NbExp=11; IntAct=EBI-547248, EBI-555067; P0AF26 narJ; NbExp=16; IntAct=EBI-547248, EBI-555043; P19317 narW; NbExp=7; IntAct=EBI-547248, EBI-555088; P19318 narY; NbExp=3; IntAct=EBI-547248, EBI-555059; # IntAct P09152 22 # InterPro IPR006468 NarG # InterPro IPR006655 Mopterin_OxRdtase_prok_CS # InterPro IPR006656 Mopterin_OxRdtase # InterPro IPR006657 MoPterin_dinucl-bd_dom # InterPro IPR006963 Mopterin_OxRdtase_4Fe-4S_dom # InterPro IPR009010 Asp_de-COase-like_dom # InterPro IPR027467 MopterinOxRdtase_cofactor_BS # InterPro IPR028189 Nitr_red_alph_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00910 Nitrogen metabolism # KEGG_Pathway ko02020 Two-component system # Organism NARG_ECOLI Escherichia coli (strain K12) # PATRIC 32117708 VBIEscCol129921_1276 # PDB 1Q16 X-ray; 1.90 A; A=1-1247 # PDB 1R27 X-ray; 2.00 A; A/C=2-1247 # PDB 1SIW X-ray; 2.20 A; A=2-1247 # PDB 1Y4Z X-ray; 2.00 A; A=2-1247 # PDB 1Y5I X-ray; 1.90 A; A=2-1247 # PDB 1Y5L X-ray; 2.50 A; A=2-1247 # PDB 1Y5N X-ray; 2.50 A; A=2-1247 # PDB 3EGW X-ray; 1.90 A; A=2-1245 # PDB 3IR5 X-ray; 2.30 A; A=1-1247 # PDB 3IR6 X-ray; 2.80 A; A=1-1247 # PDB 3IR7 X-ray; 2.50 A; A=1-1247 # PIR E64869 RDECNA # PROSITE PS00490 MOLYBDOPTERIN_PROK_2 # PROSITE PS00551 MOLYBDOPTERIN_PROK_1 # PROSITE PS00932 MOLYBDOPTERIN_PROK_3 # PROSITE PS51669 4FE4S_MOW_BIS_MGD # Pfam PF00384 Molybdopterin # Pfam PF01568 Molydop_binding # Pfam PF14710 Nitr_red_alph_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NARG_ECOLI Respiratory nitrate reductase 1 alpha chain # RefSeq NP_415742 NC_000913.3 # RefSeq WP_000032939 NZ_LN832404.1 # SIMILARITY Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. {ECO 0000305}. # SIMILARITY Contains 1 4Fe-4S Mo/W bis-MGD-type domain. {ECO:0000255|PROSITE-ProRule PRU01004}. # SMART SM00926 Molybdop_Fe4S4 # SUBCELLULAR LOCATION NARG_ECOLI Cell membrane; Peripheral membrane protein. # SUBUNIT NARG_ECOLI Dimer of heterotrimers each composed of an alpha, a beta and a gamma chain. Alpha and beta are catalytic chains; gamma chains are involved in binding the enzyme complex to the cytoplasmic membrane. Interacts with the NarJ chaperone. {ECO 0000269|PubMed 16286471, ECO 0000269|PubMed 16540088, ECO 0000269|PubMed 20236317, ECO 0000269|PubMed 9632249}. # SUPFAM SSF50692 SSF50692 # TCDB 5.A.3.1 the prokaryotic molybdopterin-containing oxidoreductase (pmo) family # TIGRFAMs TIGR01580 narG # WEB RESOURCE NARG_ECOLI Name=Worthington enzyme manual; URL="http //www.worthington-biochem.com/NAR/"; # eggNOG COG5013 LUCA # eggNOG ENOG4105CRU Bacteria BLAST swissprot:NARG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NARG_ECOLI BioCyc ECOL316407:JW1215-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1215-MONOMER BioCyc EcoCyc:NARG-MONOMER http://biocyc.org/getid?id=EcoCyc:NARG-MONOMER BioCyc MetaCyc:NARG-MONOMER http://biocyc.org/getid?id=MetaCyc:NARG-MONOMER COG COG0243 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0243 DIP DIP-10311N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10311N DOI 10.1007/BF00331275 http://dx.doi.org/10.1007/BF00331275 DOI 10.1016/0014-5793(84)81295-8 http://dx.doi.org/10.1016/0014-5793(84)81295-8 DOI 10.1016/0014-5793(89)80906-8 http://dx.doi.org/10.1016/0014-5793(89)80906-8 DOI 10.1016/j.bbrc.2006.02.133 http://dx.doi.org/10.1016/j.bbrc.2006.02.133 DOI 10.1016/j.str.2003.11.020 http://dx.doi.org/10.1016/j.str.2003.11.020 DOI 10.1021/bi972858f http://dx.doi.org/10.1021/bi972858f DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb969 http://dx.doi.org/10.1038/nsb969 DOI 10.1046/j.1365-2958.1998.00795.x http://dx.doi.org/10.1046/j.1365-2958.1998.00795.x DOI 10.1074/jbc.M505902200 http://dx.doi.org/10.1074/jbc.M505902200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1742-4658.2010.07611.x http://dx.doi.org/10.1111/j.1742-4658.2010.07611.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.7.99.4 http://www.genome.jp/dbget-bin/www_bget?EC:1.7.99.4 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L36649 http://www.ebi.ac.uk/ena/data/view/L36649 EMBL M11586 http://www.ebi.ac.uk/ena/data/view/M11586 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X01164 http://www.ebi.ac.uk/ena/data/view/X01164 EMBL X15996 http://www.ebi.ac.uk/ena/data/view/X15996 EMBL X16181 http://www.ebi.ac.uk/ena/data/view/X16181 ENZYME 1.7.99.4 http://enzyme.expasy.org/EC/1.7.99.4 EchoBASE EB0632 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0632 EcoGene EG10638 http://www.ecogene.org/geneInfo.php?eg_id=EG10638 EnsemblBacteria AAC74308 http://www.ensemblgenomes.org/id/AAC74308 EnsemblBacteria AAC74308 http://www.ensemblgenomes.org/id/AAC74308 EnsemblBacteria BAA36094 http://www.ensemblgenomes.org/id/BAA36094 EnsemblBacteria BAA36094 http://www.ensemblgenomes.org/id/BAA36094 EnsemblBacteria BAA36094 http://www.ensemblgenomes.org/id/BAA36094 EnsemblBacteria b1224 http://www.ensemblgenomes.org/id/b1224 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0031224 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031224 GO_component GO:0031235 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031235 GO_component GO:0044799 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044799 GO_function GO:0008940 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008940 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0030151 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030151 GO_function GO:0043546 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043546 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0009061 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009061 GO_process GO:0042126 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042126 GO_process GO:0042128 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042128 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0071941 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071941 GeneID 945782 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945782 HOGENOM HOG000237341 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000237341&db=HOGENOM6 InParanoid P09152 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P09152 IntAct P09152 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P09152* IntEnz 1.7.99.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.7.99.4 InterPro IPR006468 http://www.ebi.ac.uk/interpro/entry/IPR006468 InterPro IPR006655 http://www.ebi.ac.uk/interpro/entry/IPR006655 InterPro IPR006656 http://www.ebi.ac.uk/interpro/entry/IPR006656 InterPro IPR006657 http://www.ebi.ac.uk/interpro/entry/IPR006657 InterPro IPR006963 http://www.ebi.ac.uk/interpro/entry/IPR006963 InterPro IPR009010 http://www.ebi.ac.uk/interpro/entry/IPR009010 InterPro IPR027467 http://www.ebi.ac.uk/interpro/entry/IPR027467 InterPro IPR028189 http://www.ebi.ac.uk/interpro/entry/IPR028189 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1215 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1215 KEGG_Gene eco:b1224 http://www.genome.jp/dbget-bin/www_bget?eco:b1224 KEGG_Orthology KO:K00370 http://www.genome.jp/dbget-bin/www_bget?KO:K00370 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 KEGG_Reaction rn:R00798 http://www.genome.jp/dbget-bin/www_bget?rn:R00798 KEGG_Reaction rn:R01106 http://www.genome.jp/dbget-bin/www_bget?rn:R01106 MINT MINT-1233973 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1233973 OMA WQRPPRH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WQRPPRH PDB 1Q16 http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q16 PDB 1R27 http://www.ebi.ac.uk/pdbe-srv/view/entry/1R27 PDB 1SIW http://www.ebi.ac.uk/pdbe-srv/view/entry/1SIW PDB 1Y4Z http://www.ebi.ac.uk/pdbe-srv/view/entry/1Y4Z PDB 1Y5I http://www.ebi.ac.uk/pdbe-srv/view/entry/1Y5I PDB 1Y5L http://www.ebi.ac.uk/pdbe-srv/view/entry/1Y5L PDB 1Y5N http://www.ebi.ac.uk/pdbe-srv/view/entry/1Y5N PDB 3EGW http://www.ebi.ac.uk/pdbe-srv/view/entry/3EGW PDB 3IR5 http://www.ebi.ac.uk/pdbe-srv/view/entry/3IR5 PDB 3IR6 http://www.ebi.ac.uk/pdbe-srv/view/entry/3IR6 PDB 3IR7 http://www.ebi.ac.uk/pdbe-srv/view/entry/3IR7 PDBsum 1Q16 http://www.ebi.ac.uk/pdbsum/1Q16 PDBsum 1R27 http://www.ebi.ac.uk/pdbsum/1R27 PDBsum 1SIW http://www.ebi.ac.uk/pdbsum/1SIW PDBsum 1Y4Z http://www.ebi.ac.uk/pdbsum/1Y4Z PDBsum 1Y5I http://www.ebi.ac.uk/pdbsum/1Y5I PDBsum 1Y5L http://www.ebi.ac.uk/pdbsum/1Y5L PDBsum 1Y5N http://www.ebi.ac.uk/pdbsum/1Y5N PDBsum 3EGW http://www.ebi.ac.uk/pdbsum/3EGW PDBsum 3IR5 http://www.ebi.ac.uk/pdbsum/3IR5 PDBsum 3IR6 http://www.ebi.ac.uk/pdbsum/3IR6 PDBsum 3IR7 http://www.ebi.ac.uk/pdbsum/3IR7 PROSITE PS00490 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00490 PROSITE PS00551 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00551 PROSITE PS00932 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00932 PROSITE PS51669 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51669 PSORT swissprot:NARG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NARG_ECOLI PSORT-B swissprot:NARG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NARG_ECOLI PSORT2 swissprot:NARG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NARG_ECOLI Pfam PF00384 http://pfam.xfam.org/family/PF00384 Pfam PF01568 http://pfam.xfam.org/family/PF01568 Pfam PF14710 http://pfam.xfam.org/family/PF14710 Phobius swissprot:NARG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NARG_ECOLI PhylomeDB P09152 http://phylomedb.org/?seqid=P09152 ProteinModelPortal P09152 http://www.proteinmodelportal.org/query/uniprot/P09152 PubMed 12910261 http://www.ncbi.nlm.nih.gov/pubmed/12910261 PubMed 14725769 http://www.ncbi.nlm.nih.gov/pubmed/14725769 PubMed 16286471 http://www.ncbi.nlm.nih.gov/pubmed/16286471 PubMed 16540088 http://www.ncbi.nlm.nih.gov/pubmed/16540088 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20236317 http://www.ncbi.nlm.nih.gov/pubmed/20236317 PubMed 2233673 http://www.ncbi.nlm.nih.gov/pubmed/2233673 PubMed 2668029 http://www.ncbi.nlm.nih.gov/pubmed/2668029 PubMed 2674654 http://www.ncbi.nlm.nih.gov/pubmed/2674654 PubMed 2995309 http://www.ncbi.nlm.nih.gov/pubmed/2995309 PubMed 3053688 http://www.ncbi.nlm.nih.gov/pubmed/3053688 PubMed 3308846 http://www.ncbi.nlm.nih.gov/pubmed/3308846 PubMed 6094247 http://www.ncbi.nlm.nih.gov/pubmed/6094247 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9585550 http://www.ncbi.nlm.nih.gov/pubmed/9585550 PubMed 9632249 http://www.ncbi.nlm.nih.gov/pubmed/9632249 RefSeq NP_415742 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415742 RefSeq WP_000032939 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000032939 SMART SM00926 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00926 SMR P09152 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P09152 STRING 511145.b1224 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1224&targetmode=cogs STRING COG0243 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0243&targetmode=cogs SUPFAM SSF50692 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50692 TCDB 5.A.3.1 http://www.tcdb.org/search/result.php?tc=5.A.3.1 TIGRFAMs TIGR01580 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01580 UniProtKB NARG_ECOLI http://www.uniprot.org/uniprot/NARG_ECOLI UniProtKB-AC P09152 http://www.uniprot.org/uniprot/P09152 charge swissprot:NARG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NARG_ECOLI eggNOG COG5013 http://eggnogapi.embl.de/nog_data/html/tree/COG5013 eggNOG ENOG4105CRU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CRU epestfind swissprot:NARG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NARG_ECOLI garnier swissprot:NARG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NARG_ECOLI helixturnhelix swissprot:NARG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NARG_ECOLI hmoment swissprot:NARG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NARG_ECOLI iep swissprot:NARG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NARG_ECOLI inforesidue swissprot:NARG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NARG_ECOLI octanol swissprot:NARG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NARG_ECOLI pepcoil swissprot:NARG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NARG_ECOLI pepdigest swissprot:NARG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NARG_ECOLI pepinfo swissprot:NARG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NARG_ECOLI pepnet swissprot:NARG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NARG_ECOLI pepstats swissprot:NARG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NARG_ECOLI pepwheel swissprot:NARG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NARG_ECOLI pepwindow swissprot:NARG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NARG_ECOLI sigcleave swissprot:NARG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NARG_ECOLI ## Database ID URL or Descriptions # BioGrid 4259569 11 # DISRUPTION PHENOTYPE Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain. {ECO:0000269|PubMed 20345943}. # EcoGene EG14119 yfcP # FUNCTION YFCP_ECOLI Part of the yfcOPQRSUV fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes. {ECO 0000269|PubMed 20345943}. # GO_component GO:0009289 pilus; IEA:UniProtKB-SubCell. # GO_process GO:0007155 cell adhesion; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0007155 cell adhesion # Gene3D 2.60.40.1090 -; 1. # INDUCTION Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression. {ECO:0000269|PubMed 20345943}. # InterPro IPR000259 Adhesion_dom_fimbrial # InterPro IPR008966 Adhesion_dom # MISCELLANEOUS The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed. {ECO:0000305|PubMed 20345943}. # Organism YFCP_ECOLI Escherichia coli (strain K12) # PATRIC 32120039 VBIEscCol129921_2429 # PIR C65006 C65006 # Pfam PF00419 Fimbrial # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFCP_ECOLI Uncharacterized fimbrial-like protein YfcP # RefSeq NP_416836 NC_000913.3 # RefSeq WP_001043398 NZ_LN832404.1 # SIMILARITY Belongs to the fimbrial protein family. {ECO 0000305}. # SUBCELLULAR LOCATION YFCP_ECOLI Fimbrium {ECO 0000305}. # SUPFAM SSF49401 SSF49401 # eggNOG ENOG4105US4 Bacteria # eggNOG ENOG4111UQM LUCA BLAST swissprot:YFCP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFCP_ECOLI BioCyc ECOL316407:JW2330-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2330-MONOMER BioCyc EcoCyc:G7204-MONOMER http://biocyc.org/getid?id=EcoCyc:G7204-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1462-2920.2010.02202.x http://dx.doi.org/10.1111/j.1462-2920.2010.02202.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3872 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3872 EcoGene EG14119 http://www.ecogene.org/geneInfo.php?eg_id=EG14119 EnsemblBacteria AAC75393 http://www.ensemblgenomes.org/id/AAC75393 EnsemblBacteria AAC75393 http://www.ensemblgenomes.org/id/AAC75393 EnsemblBacteria BAE76690 http://www.ensemblgenomes.org/id/BAE76690 EnsemblBacteria BAE76690 http://www.ensemblgenomes.org/id/BAE76690 EnsemblBacteria BAE76690 http://www.ensemblgenomes.org/id/BAE76690 EnsemblBacteria b2333 http://www.ensemblgenomes.org/id/b2333 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009289 GO_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 Gene3D 2.60.40.1090 http://www.cathdb.info/version/latest/superfamily/2.60.40.1090 GeneID 946788 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946788 HOGENOM HOG000260127 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260127&db=HOGENOM6 InParanoid P76499 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76499 InterPro IPR000259 http://www.ebi.ac.uk/interpro/entry/IPR000259 InterPro IPR008966 http://www.ebi.ac.uk/interpro/entry/IPR008966 KEGG_Gene ecj:JW2330 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2330 KEGG_Gene eco:b2333 http://www.genome.jp/dbget-bin/www_bget?eco:b2333 OMA IGMETTD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IGMETTD PSORT swissprot:YFCP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFCP_ECOLI PSORT-B swissprot:YFCP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFCP_ECOLI PSORT2 swissprot:YFCP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFCP_ECOLI Pfam PF00419 http://pfam.xfam.org/family/PF00419 Phobius swissprot:YFCP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFCP_ECOLI PhylomeDB P76499 http://phylomedb.org/?seqid=P76499 ProteinModelPortal P76499 http://www.proteinmodelportal.org/query/uniprot/P76499 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20345943 http://www.ncbi.nlm.nih.gov/pubmed/20345943 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416836 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416836 RefSeq WP_001043398 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001043398 SMR P76499 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76499 STRING 511145.b2333 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2333&targetmode=cogs SUPFAM SSF49401 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49401 UniProtKB YFCP_ECOLI http://www.uniprot.org/uniprot/YFCP_ECOLI UniProtKB-AC P76499 http://www.uniprot.org/uniprot/P76499 charge swissprot:YFCP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFCP_ECOLI eggNOG ENOG4105US4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105US4 eggNOG ENOG4111UQM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111UQM epestfind swissprot:YFCP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFCP_ECOLI garnier swissprot:YFCP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFCP_ECOLI helixturnhelix swissprot:YFCP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFCP_ECOLI hmoment swissprot:YFCP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFCP_ECOLI iep swissprot:YFCP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFCP_ECOLI inforesidue swissprot:YFCP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFCP_ECOLI octanol swissprot:YFCP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFCP_ECOLI pepcoil swissprot:YFCP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFCP_ECOLI pepdigest swissprot:YFCP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFCP_ECOLI pepinfo swissprot:YFCP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFCP_ECOLI pepnet swissprot:YFCP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFCP_ECOLI pepstats swissprot:YFCP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFCP_ECOLI pepwheel swissprot:YFCP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFCP_ECOLI pepwindow swissprot:YFCP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFCP_ECOLI sigcleave swissprot:YFCP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFCP_ECOLI ## Database ID URL or Descriptions # ALTERNATIVE PRODUCTS IF2_ECOLI Event=Alternative initiation; Named isoforms=3; Name=Alpha {ECO 0000269|PubMed 3894004}; IsoId=P0A705-1; Sequence=Displayed; Note=Isoform alpha is approximately 2-fold more abundant than the combined beta isoforms. Optimal growth requires both alpha and beta IF2. {ECO 0000305|PubMed 1374802}; Name=Beta {ECO 0000269|PubMed 1374802, ECO 0000269|PubMed 1764105, ECO 0000269|PubMed 3894004}; IsoId=P0A705-2; Sequence=VSP_018758, VSP_018759; Note=Also called beta1. {ECO 0000305|PubMed 1374802}; Name=Beta' {ECO 0000269|PubMed 1374802, ECO 0000269|PubMed 1764105}; IsoId=P0A705-3; Sequence=VSP_018760; Note=Also called beta2. {ECO 0000305|PubMed 1374802}; # DISRUPTION PHENOTYPE Essential, it cannot be deleted. The C- terminal region (residues 165-890) is sufficient for growth at 42 degrees Celsius, although it grows more slowly at 37 degrees and is cold-sensitive at 30 degrees Celsius (PubMed:1374802). {ECO 0000269|PubMed:1374802}. # EcoGene EG10505 infB # FUNCTION IF2_ECOLI One of the essential components for the initiation of protein synthesis. May protect N-formylmethionyl-tRNA(fMet) from spontaneous hydrolysis. Promotes N-formylmethionyl-tRNA(fMet) binding to the 30S pre-initiation complex (PIC) (PubMed 1764105, PubMed 20224578). Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. Upon addition of the 50S ribosomal subunit, IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex. {ECO 0000269|PubMed 1764105, ECO 0000269|PubMed 20224578, ECO 0000269|PubMed 22562136, ECO 0000269|PubMed 2444251}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0003743 translation initiation factor activity; IDA:EcoliWiki. # GO_function GO:0003924 GTPase activity; IDA:EcoCyc. # GO_function GO:0005525 GTP binding; IEA:UniProtKB-KW. # GO_function GO:0043024 ribosomal small subunit binding; IDA:EcoCyc. # GO_function GO:0097216 guanosine tetraphosphate binding; IDA:EcoCyc. # GO_process GO:0006413 translational initiation; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003924 GTPase activity # GOslim_function GO:0008135 translation factor activity, RNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.10050 -; 1. # Gene3D 3.40.50.300 -; 1. # HAMAP MF_00100_B IF_2_B # IntAct P0A705 45 # InterPro IPR000178 TF_IF2_bacterial-like # InterPro IPR000795 TF_GTP-bd_dom # InterPro IPR005225 Small_GTP-bd_dom # InterPro IPR006847 IF2_N # InterPro IPR009000 Transl_B-barrel # InterPro IPR009061 DNA-bd_dom_put # InterPro IPR013575 IF2_assoc_dom_bac # InterPro IPR023115 TIF_IF2_dom3 # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko03012 Translation factors # MISCELLANEOUS Silent mutations of codon 158, which no longer function as alternative start codons, decrease beta isoform expression to 31 to 50%, the strongest mutation is GUG to GUC. {ECO:0000269|PubMed 1374802}. # MISCELLANEOUS When overexpressed partially suppresses the slow growth and decreased 70S ribosome phenotype of an rsgA knockout; RsgA may be involved in 30S ribosomal subunit biogenesis. {ECO:0000269|PubMed 18223068}. # Organism IF2_ECOLI Escherichia coli (strain K12) # PATRIC 32121754 VBIEscCol129921_3263 # PDB 1ND9 NMR; -; A=2-50 # PDB 1ZO1 EM; 13.80 A; I=388-888 # PDB 3JCJ EM; 3.70 A; f=1-890 # PDB 3JCN EM; 4.60 A; b=1-890 # PIR D65107 FIEC2 # PROSITE PS01176 IF2 # PROSITE PS51722 G_TR_2 # PTM IF2_ECOLI A proteolyzed form, called IF2 gamma (begins with residue 290), can be detected during purification which has all the activities expected for this protein, although it is slightly less efficient than full-length protein. It is not clear if it exists in vivo. {ECO 0000269|PubMed 2444251}. # Pfam PF04760 IF2_N; 2 # Pfam PF08364 IF2_assoc # Pfam PF11987 IF-2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName IF2_ECOLI Translation initiation factor IF-2 # RefSeq NP_417637 NC_000913.3 # RefSeq WP_000133044 NZ_LN832404.1 # SIMILARITY Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. {ECO 0000305}. # SIMILARITY Contains 1 tr-type G (guanine nucleotide-binding) domain. {ECO 0000305}. # SUBCELLULAR LOCATION IF2_ECOLI Cytoplasm {ECO 0000269|PubMed 1764105}. # SUBUNIT IF2_ECOLI Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly. {ECO 0000269|PubMed 20224578, ECO 0000269|PubMed 21750663, ECO 0000269|PubMed 22562136}. # SUPFAM SSF46955 SSF46955 # SUPFAM SSF50447 SSF50447; 2 # SUPFAM SSF52156 SSF52156 # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR00231 small_GTP # TIGRFAMs TIGR00487 IF-2 # eggNOG COG0532 LUCA # eggNOG ENOG4107QHU Bacteria BLAST swissprot:IF2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:IF2_ECOLI BioCyc ECOL316407:JW3137-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3137-MONOMER BioCyc EcoCyc:EG10505-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10505-MONOMER COG COG0532 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0532 DIP DIP-36182N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36182N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0006-291X(91)92118-4 http://dx.doi.org/10.1016/0006-291X(91)92118-4 DOI 10.1016/0022-2836(92)91026-L http://dx.doi.org/10.1016/0022-2836(92)91026-L DOI 10.1016/0300-9084(91)90191-3 http://dx.doi.org/10.1016/0300-9084(91)90191-3 DOI 10.1016/S0014-5793(97)01472-5 http://dx.doi.org/10.1016/S0014-5793(97)01472-5 DOI 10.1021/bi00390a028 http://dx.doi.org/10.1021/bi00390a028 DOI 10.1038/embor.2010.12 http://dx.doi.org/10.1038/embor.2010.12 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsmb.2285 http://dx.doi.org/10.1038/nsmb.2285 DOI 10.1073/pnas.81.24.7787 http://dx.doi.org/10.1073/pnas.81.24.7787 DOI 10.1074/jbc.M212960200 http://dx.doi.org/10.1074/jbc.M212960200 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/nar/12.7.3333 http://dx.doi.org/10.1093/nar/12.7.3333 DOI 10.1093/nar/16.22.10803 http://dx.doi.org/10.1093/nar/16.22.10803 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01744-07 http://dx.doi.org/10.1128/JB.01744-07 DOI 10.1371/journal.pbio.1001095 http://dx.doi.org/10.1371/journal.pbio.1001095 DOI 10.3109/10409238.2012.678284 http://dx.doi.org/10.3109/10409238.2012.678284 EMBL AJ002402 http://www.ebi.ac.uk/ena/data/view/AJ002402 EMBL AJ002403 http://www.ebi.ac.uk/ena/data/view/AJ002403 EMBL AJ002404 http://www.ebi.ac.uk/ena/data/view/AJ002404 EMBL AJ002405 http://www.ebi.ac.uk/ena/data/view/AJ002405 EMBL AJ002406 http://www.ebi.ac.uk/ena/data/view/AJ002406 EMBL AJ002407 http://www.ebi.ac.uk/ena/data/view/AJ002407 EMBL AJ002408 http://www.ebi.ac.uk/ena/data/view/AJ002408 EMBL AJ002409 http://www.ebi.ac.uk/ena/data/view/AJ002409 EMBL AJ002410 http://www.ebi.ac.uk/ena/data/view/AJ002410 EMBL AJ002411 http://www.ebi.ac.uk/ena/data/view/AJ002411 EMBL AJ002412 http://www.ebi.ac.uk/ena/data/view/AJ002412 EMBL AJ002413 http://www.ebi.ac.uk/ena/data/view/AJ002413 EMBL AJ002537 http://www.ebi.ac.uk/ena/data/view/AJ002537 EMBL AJ002537 http://www.ebi.ac.uk/ena/data/view/AJ002537 EMBL AJ002537 http://www.ebi.ac.uk/ena/data/view/AJ002537 EMBL AJ002538 http://www.ebi.ac.uk/ena/data/view/AJ002538 EMBL AJ002538 http://www.ebi.ac.uk/ena/data/view/AJ002538 EMBL AJ002538 http://www.ebi.ac.uk/ena/data/view/AJ002538 EMBL AJ002539 http://www.ebi.ac.uk/ena/data/view/AJ002539 EMBL AJ002539 http://www.ebi.ac.uk/ena/data/view/AJ002539 EMBL AJ002539 http://www.ebi.ac.uk/ena/data/view/AJ002539 EMBL AJ002540 http://www.ebi.ac.uk/ena/data/view/AJ002540 EMBL AJ002540 http://www.ebi.ac.uk/ena/data/view/AJ002540 EMBL AJ002540 http://www.ebi.ac.uk/ena/data/view/AJ002540 EMBL AJ002541 http://www.ebi.ac.uk/ena/data/view/AJ002541 EMBL AJ002541 http://www.ebi.ac.uk/ena/data/view/AJ002541 EMBL AJ002541 http://www.ebi.ac.uk/ena/data/view/AJ002541 EMBL AJ002542 http://www.ebi.ac.uk/ena/data/view/AJ002542 EMBL AJ002542 http://www.ebi.ac.uk/ena/data/view/AJ002542 EMBL AJ002542 http://www.ebi.ac.uk/ena/data/view/AJ002542 EMBL AJ132861 http://www.ebi.ac.uk/ena/data/view/AJ132861 EMBL AJ132861 http://www.ebi.ac.uk/ena/data/view/AJ132861 EMBL AJ132861 http://www.ebi.ac.uk/ena/data/view/AJ132861 EMBL AJ132862 http://www.ebi.ac.uk/ena/data/view/AJ132862 EMBL AJ132862 http://www.ebi.ac.uk/ena/data/view/AJ132862 EMBL AJ132862 http://www.ebi.ac.uk/ena/data/view/AJ132862 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X00513 http://www.ebi.ac.uk/ena/data/view/X00513 EMBL X00513 http://www.ebi.ac.uk/ena/data/view/X00513 EMBL X13775 http://www.ebi.ac.uk/ena/data/view/X13775 EchoBASE EB0500 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0500 EcoGene EG10505 http://www.ecogene.org/geneInfo.php?eg_id=EG10505 EnsemblBacteria AAC76202 http://www.ensemblgenomes.org/id/AAC76202 EnsemblBacteria AAC76202 http://www.ensemblgenomes.org/id/AAC76202 EnsemblBacteria BAE77214 http://www.ensemblgenomes.org/id/BAE77214 EnsemblBacteria BAE77214 http://www.ensemblgenomes.org/id/BAE77214 EnsemblBacteria BAE77214 http://www.ensemblgenomes.org/id/BAE77214 EnsemblBacteria b3168 http://www.ensemblgenomes.org/id/b3168 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0003743 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003743 GO_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_function GO:0043024 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043024 GO_function GO:0097216 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097216 GO_process GO:0006413 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006413 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GOslim_function GO:0008135 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008135 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.10050 http://www.cathdb.info/version/latest/superfamily/3.40.50.10050 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947684 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947684 HAMAP MF_00100_B http://hamap.expasy.org/unirule/MF_00100_B InParanoid P0A705 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A705 IntAct P0A705 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A705* InterPro IPR000178 http://www.ebi.ac.uk/interpro/entry/IPR000178 InterPro IPR000795 http://www.ebi.ac.uk/interpro/entry/IPR000795 InterPro IPR005225 http://www.ebi.ac.uk/interpro/entry/IPR005225 InterPro IPR006847 http://www.ebi.ac.uk/interpro/entry/IPR006847 InterPro IPR009000 http://www.ebi.ac.uk/interpro/entry/IPR009000 InterPro IPR009061 http://www.ebi.ac.uk/interpro/entry/IPR009061 InterPro IPR013575 http://www.ebi.ac.uk/interpro/entry/IPR013575 InterPro IPR023115 http://www.ebi.ac.uk/interpro/entry/IPR023115 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko03012 http://www.genome.jp/dbget-bin/www_bget?ko03012 KEGG_Gene ecj:JW3137 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3137 KEGG_Gene eco:b3168 http://www.genome.jp/dbget-bin/www_bget?eco:b3168 KEGG_Orthology KO:K02519 http://www.genome.jp/dbget-bin/www_bget?KO:K02519 MINT MINT-1235405 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1235405 OMA KFAVVES http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KFAVVES PDB 1ND9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ND9 PDB 1ZO1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZO1 PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDBsum 1ND9 http://www.ebi.ac.uk/pdbsum/1ND9 PDBsum 1ZO1 http://www.ebi.ac.uk/pdbsum/1ZO1 PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PROSITE PS01176 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01176 PROSITE PS51722 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51722 PSORT swissprot:IF2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:IF2_ECOLI PSORT-B swissprot:IF2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:IF2_ECOLI PSORT2 swissprot:IF2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:IF2_ECOLI Pfam PF04760 http://pfam.xfam.org/family/PF04760 Pfam PF08364 http://pfam.xfam.org/family/PF08364 Pfam PF11987 http://pfam.xfam.org/family/PF11987 Phobius swissprot:IF2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:IF2_ECOLI PhylomeDB P0A705 http://phylomedb.org/?seqid=P0A705 ProteinModelPortal P0A705 http://www.proteinmodelportal.org/query/uniprot/P0A705 PubMed 12600987 http://www.ncbi.nlm.nih.gov/pubmed/12600987 PubMed 1374802 http://www.ncbi.nlm.nih.gov/pubmed/1374802 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1764105 http://www.ncbi.nlm.nih.gov/pubmed/1764105 PubMed 1805969 http://www.ncbi.nlm.nih.gov/pubmed/1805969 PubMed 18223068 http://www.ncbi.nlm.nih.gov/pubmed/18223068 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 20224578 http://www.ncbi.nlm.nih.gov/pubmed/20224578 PubMed 21750663 http://www.ncbi.nlm.nih.gov/pubmed/21750663 PubMed 22515367 http://www.ncbi.nlm.nih.gov/pubmed/22515367 PubMed 22562136 http://www.ncbi.nlm.nih.gov/pubmed/22562136 PubMed 2444251 http://www.ncbi.nlm.nih.gov/pubmed/2444251 PubMed 2849753 http://www.ncbi.nlm.nih.gov/pubmed/2849753 PubMed 3894004 http://www.ncbi.nlm.nih.gov/pubmed/3894004 PubMed 6096856 http://www.ncbi.nlm.nih.gov/pubmed/6096856 PubMed 6326058 http://www.ncbi.nlm.nih.gov/pubmed/6326058 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9428651 http://www.ncbi.nlm.nih.gov/pubmed/9428651 RefSeq NP_417637 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417637 RefSeq WP_000133044 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000133044 SMR P0A705 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A705 STRING 511145.b3168 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3168&targetmode=cogs STRING COG0532 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0532&targetmode=cogs SUPFAM SSF46955 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46955 SUPFAM SSF50447 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50447 SUPFAM SSF52156 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52156 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR00231 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00231 TIGRFAMs TIGR00487 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00487 UniProtKB IF2_ECOLI http://www.uniprot.org/uniprot/IF2_ECOLI UniProtKB-AC P0A705 http://www.uniprot.org/uniprot/P0A705 charge swissprot:IF2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:IF2_ECOLI eggNOG COG0532 http://eggnogapi.embl.de/nog_data/html/tree/COG0532 eggNOG ENOG4107QHU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QHU epestfind swissprot:IF2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:IF2_ECOLI garnier swissprot:IF2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:IF2_ECOLI helixturnhelix swissprot:IF2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:IF2_ECOLI hmoment swissprot:IF2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:IF2_ECOLI iep swissprot:IF2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:IF2_ECOLI inforesidue swissprot:IF2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:IF2_ECOLI octanol swissprot:IF2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:IF2_ECOLI pepcoil swissprot:IF2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:IF2_ECOLI pepdigest swissprot:IF2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:IF2_ECOLI pepinfo swissprot:IF2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:IF2_ECOLI pepnet swissprot:IF2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:IF2_ECOLI pepstats swissprot:IF2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:IF2_ECOLI pepwheel swissprot:IF2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:IF2_ECOLI pepwindow swissprot:IF2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:IF2_ECOLI sigcleave swissprot:IF2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:IF2_ECOLI ## Database ID URL or Descriptions # CAUTION In strain W3110, the sequence is interrupted by the insertion of an IS5 element between positions 291 and 292. {ECO 0000305}. # EcoGene EG11006 tnaB # FUNCTION TNAB_ECOLI Involved in tryptophan transport across the cytoplasmic membrane. Plays a role in transporting tryptophan which is to be used catabolically. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IEA:InterPro. # GO_function GO:0015173 aromatic amino acid transmembrane transporter activity; IEA:InterPro. # GO_function GO:0015293 symporter activity; IMP:EcoCyc. # GO_process GO:0003333 amino acid transmembrane transport; IDA:EcoCyc. # GO_process GO:0006569 tryptophan catabolic process; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0055085 transmembrane transport # INDUCTION TNAB_ECOLI By tryptophan. Is subject to catabolic repression. # InterPro IPR002091 ArAA_permease # InterPro IPR013059 Trp_tyr_transpt # InterPro IPR013061 Trp/try_permease_CS # InterPro IPR018227 Tryptophan/tyrosine_permease # KEGG_Brite ko02000 Transporters # Organism TNAB_ECOLI Escherichia coli (strain K12) # PATRIC 32122913 VBIEscCol129921_3832 # PIR A39412 A39412 # PRINTS PR00166 AROAAPRMEASE # PROSITE PS00594 AROMATIC_AA_PERMEASE_1 # Pfam PF03222 Trp_Tyr_perm # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TNAB_ECOLI Low affinity tryptophan permease # RefSeq NP_418165 NC_000913.3 # RefSeq WP_000131925 NZ_LN832404.1 # SIMILARITY Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION TNAB_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.42.1 the hydroxy/aromatic amino acid permease (haaap) family # TIGRFAMs TIGR00837 araaP # eggNOG COG0814 LUCA # eggNOG ENOG4108P6C Bacteria BLAST swissprot:TNAB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TNAB_ECOLI BioCyc ECOL316407:JW5619-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5619-MONOMER BioCyc ECOL316407:JW5622-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5622-MONOMER BioCyc EcoCyc:TNAB-MONOMER http://biocyc.org/getid?id=EcoCyc:TNAB-MONOMER BioCyc MetaCyc:TNAB-MONOMER http://biocyc.org/getid?id=MetaCyc:TNAB-MONOMER COG COG0814 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0814 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K00032 http://www.ebi.ac.uk/ena/data/view/K00032 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M59914 http://www.ebi.ac.uk/ena/data/view/M59914 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0999 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0999 EcoGene EG11006 http://www.ecogene.org/geneInfo.php?eg_id=EG11006 EnsemblBacteria AAC76732 http://www.ensemblgenomes.org/id/AAC76732 EnsemblBacteria AAC76732 http://www.ensemblgenomes.org/id/AAC76732 EnsemblBacteria BAE77581 http://www.ensemblgenomes.org/id/BAE77581 EnsemblBacteria BAE77581 http://www.ensemblgenomes.org/id/BAE77581 EnsemblBacteria BAE77581 http://www.ensemblgenomes.org/id/BAE77581 EnsemblBacteria BAE77583 http://www.ensemblgenomes.org/id/BAE77583 EnsemblBacteria BAE77583 http://www.ensemblgenomes.org/id/BAE77583 EnsemblBacteria BAE77583 http://www.ensemblgenomes.org/id/BAE77583 EnsemblBacteria b3709 http://www.ensemblgenomes.org/id/b3709 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015173 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015173 GO_function GO:0015293 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293 GO_process GO:0003333 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003333 GO_process GO:0006569 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006569 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 948220 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948220 HOGENOM HOG000269674 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000269674&db=HOGENOM6 InParanoid P23173 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23173 InterPro IPR002091 http://www.ebi.ac.uk/interpro/entry/IPR002091 InterPro IPR013059 http://www.ebi.ac.uk/interpro/entry/IPR013059 InterPro IPR013061 http://www.ebi.ac.uk/interpro/entry/IPR013061 InterPro IPR018227 http://www.ebi.ac.uk/interpro/entry/IPR018227 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5619 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5619 KEGG_Gene ecj:JW5622 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5622 KEGG_Gene eco:b3709 http://www.genome.jp/dbget-bin/www_bget?eco:b3709 KEGG_Orthology KO:K03836 http://www.genome.jp/dbget-bin/www_bget?KO:K03836 OMA IICYGKK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IICYGKK PRINTS PR00166 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00166 PROSITE PS00594 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00594 PSORT swissprot:TNAB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TNAB_ECOLI PSORT-B swissprot:TNAB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TNAB_ECOLI PSORT2 swissprot:TNAB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TNAB_ECOLI Pfam PF03222 http://pfam.xfam.org/family/PF03222 Phobius swissprot:TNAB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TNAB_ECOLI PhylomeDB P23173 http://phylomedb.org/?seqid=P23173 ProteinModelPortal P23173 http://www.proteinmodelportal.org/query/uniprot/P23173 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2022620 http://www.ncbi.nlm.nih.gov/pubmed/2022620 PubMed 6268608 http://www.ncbi.nlm.nih.gov/pubmed/6268608 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418165 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418165 RefSeq WP_000131925 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000131925 STRING 511145.b3709 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3709&targetmode=cogs STRING COG0814 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0814&targetmode=cogs TCDB 2.A.42.1 http://www.tcdb.org/search/result.php?tc=2.A.42.1 TIGRFAMs TIGR00837 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00837 UniProtKB TNAB_ECOLI http://www.uniprot.org/uniprot/TNAB_ECOLI UniProtKB-AC P23173 http://www.uniprot.org/uniprot/P23173 charge swissprot:TNAB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TNAB_ECOLI eggNOG COG0814 http://eggnogapi.embl.de/nog_data/html/tree/COG0814 eggNOG ENOG4108P6C http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108P6C epestfind swissprot:TNAB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TNAB_ECOLI garnier swissprot:TNAB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TNAB_ECOLI helixturnhelix swissprot:TNAB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TNAB_ECOLI hmoment swissprot:TNAB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TNAB_ECOLI iep swissprot:TNAB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TNAB_ECOLI inforesidue swissprot:TNAB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TNAB_ECOLI octanol swissprot:TNAB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TNAB_ECOLI pepcoil swissprot:TNAB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TNAB_ECOLI pepdigest swissprot:TNAB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TNAB_ECOLI pepinfo swissprot:TNAB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TNAB_ECOLI pepnet swissprot:TNAB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TNAB_ECOLI pepstats swissprot:TNAB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TNAB_ECOLI pepwheel swissprot:TNAB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TNAB_ECOLI pepwindow swissprot:TNAB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TNAB_ECOLI sigcleave swissprot:TNAB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TNAB_ECOLI ## Database ID URL or Descriptions # BioGrid 4262521 264 # EcoGene EG12241 mdtF # FUNCTION MDTF_ECOLI Part of the tripartite efflux system MdtEF-TolC, which confers resistance to compounds such as rhodamine 6G, erythromycin, doxorubicin, ethidium bromide, TPP, SDS, deoxycholate, crystal violet and benzalkonium. {ECO 0000269|PubMed 11566977}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005215 transporter activity; IMP:EcoliWiki. # GO_process GO:0006855 drug transmembrane transport; IMP:EcoliWiki. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0008150 biological_process # GOslim_process GO:0055085 transmembrane transport # Gene3D 3.30.2090.10 -; 2. # INDUCTION MDTF_ECOLI Induced by EvgA, probably via YdeO. {ECO 0000269|PubMed 11914367, ECO 0000269|PubMed 12399493, ECO 0000269|PubMed 12694615, ECO 0000269|PubMed 14523115}. # InterPro IPR001036 Acrflvin-R # InterPro IPR004764 HAE1 # InterPro IPR027463 AcrB_DN_DC_subdom # Organism MDTF_ECOLI Escherichia coli (strain K12) # PATRIC 32122488 VBIEscCol129921_3622 # PIR S47734 S47734 # PRINTS PR00702 ACRIFLAVINRP # Pfam PF00873 ACR_tran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MDTF_ECOLI Multidrug resistance protein MdtF # RefSeq NP_417971 NC_000913.3 # RefSeq WP_000024872 NZ_LN832404.1 # SIMILARITY Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. {ECO 0000305}. # SUBCELLULAR LOCATION MDTF_ECOLI Cell inner membrane {ECO 0000269|PubMed 16079137}; Multi-pass membrane protein {ECO 0000269|PubMed 16079137}. # SUBUNIT MDTF_ECOLI Homotrimer. Part of the tripartite efflux system MdtEF- TolC, which is composed of an inner membrane transporter, MdtF, a membrane fusion protein, MdtE, and an outer membrane component, TolC. The complex forms a large protein conduit and can translocate molecules across both the inner and outer membranes. {ECO 0000269|PubMed 11914367, ECO 0000269|PubMed 16079137}. # SUPFAM SSF82714 SSF82714; 2 # TCDB 2.A.6.2.13 the resistance-nodulation-cell division (rnd) superfamily # TIGRFAMs TIGR00915 2A0602 # eggNOG COG0841 LUCA # eggNOG ENOG4105BZS Bacteria BLAST swissprot:MDTF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MDTF_ECOLI BioCyc ECOL316407:JW3482-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3482-MONOMER BioCyc EcoCyc:YHIV-MONOMER http://biocyc.org/getid?id=EcoCyc:YHIV-MONOMER COG COG0841 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0841 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2003.03477.x http://dx.doi.org/10.1046/j.1365-2958.2003.03477.x DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1099/mic.0.26460-0 http://dx.doi.org/10.1099/mic.0.26460-0 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.183.20.5803-5812.2001 http://dx.doi.org/10.1128/JB.183.20.5803-5812.2001 DOI 10.1128/JB.184.22.6225-6234.2002 http://dx.doi.org/10.1128/JB.184.22.6225-6234.2002 DOI 10.1128/JB.184.8.2319-2323.2002 http://dx.doi.org/10.1128/JB.184.8.2319-2323.2002 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2152 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2152 EcoGene EG12241 http://www.ecogene.org/geneInfo.php?eg_id=EG12241 EnsemblBacteria AAC76539 http://www.ensemblgenomes.org/id/AAC76539 EnsemblBacteria AAC76539 http://www.ensemblgenomes.org/id/AAC76539 EnsemblBacteria BAE77780 http://www.ensemblgenomes.org/id/BAE77780 EnsemblBacteria BAE77780 http://www.ensemblgenomes.org/id/BAE77780 EnsemblBacteria BAE77780 http://www.ensemblgenomes.org/id/BAE77780 EnsemblBacteria b3514 http://www.ensemblgenomes.org/id/b3514 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_process GO:0006855 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006855 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 3.30.2090.10 http://www.cathdb.info/version/latest/superfamily/3.30.2090.10 GeneID 948030 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948030 HOGENOM HOG000158129 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000158129&db=HOGENOM6 InParanoid P37637 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37637 IntAct P37637 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37637* InterPro IPR001036 http://www.ebi.ac.uk/interpro/entry/IPR001036 InterPro IPR004764 http://www.ebi.ac.uk/interpro/entry/IPR004764 InterPro IPR027463 http://www.ebi.ac.uk/interpro/entry/IPR027463 KEGG_Gene ecj:JW3482 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3482 KEGG_Gene eco:b3514 http://www.genome.jp/dbget-bin/www_bget?eco:b3514 KEGG_Orthology KO:K03296 http://www.genome.jp/dbget-bin/www_bget?KO:K03296 OMA KNASGEM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KNASGEM PRINTS PR00702 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00702 PSORT swissprot:MDTF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MDTF_ECOLI PSORT-B swissprot:MDTF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MDTF_ECOLI PSORT2 swissprot:MDTF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MDTF_ECOLI Pfam PF00873 http://pfam.xfam.org/family/PF00873 Phobius swissprot:MDTF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MDTF_ECOLI PhylomeDB P37637 http://phylomedb.org/?seqid=P37637 ProteinModelPortal P37637 http://www.proteinmodelportal.org/query/uniprot/P37637 PubMed 11566977 http://www.ncbi.nlm.nih.gov/pubmed/11566977 PubMed 11914367 http://www.ncbi.nlm.nih.gov/pubmed/11914367 PubMed 12399493 http://www.ncbi.nlm.nih.gov/pubmed/12399493 PubMed 12694615 http://www.ncbi.nlm.nih.gov/pubmed/12694615 PubMed 14523115 http://www.ncbi.nlm.nih.gov/pubmed/14523115 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417971 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417971 RefSeq WP_000024872 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000024872 SMR P37637 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37637 STRING 511145.b3514 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3514&targetmode=cogs STRING COG0841 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0841&targetmode=cogs SUPFAM SSF82714 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF82714 TCDB 2.A.6.2.13 http://www.tcdb.org/search/result.php?tc=2.A.6.2.13 TIGRFAMs TIGR00915 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00915 UniProtKB MDTF_ECOLI http://www.uniprot.org/uniprot/MDTF_ECOLI UniProtKB-AC P37637 http://www.uniprot.org/uniprot/P37637 charge swissprot:MDTF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MDTF_ECOLI eggNOG COG0841 http://eggnogapi.embl.de/nog_data/html/tree/COG0841 eggNOG ENOG4105BZS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZS epestfind swissprot:MDTF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MDTF_ECOLI garnier swissprot:MDTF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MDTF_ECOLI helixturnhelix swissprot:MDTF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MDTF_ECOLI hmoment swissprot:MDTF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MDTF_ECOLI iep swissprot:MDTF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MDTF_ECOLI inforesidue swissprot:MDTF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MDTF_ECOLI octanol swissprot:MDTF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MDTF_ECOLI pepcoil swissprot:MDTF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MDTF_ECOLI pepdigest swissprot:MDTF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MDTF_ECOLI pepinfo swissprot:MDTF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MDTF_ECOLI pepnet swissprot:MDTF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MDTF_ECOLI pepstats swissprot:MDTF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MDTF_ECOLI pepwheel swissprot:MDTF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MDTF_ECOLI pepwindow swissprot:MDTF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MDTF_ECOLI sigcleave swissprot:MDTF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MDTF_ECOLI ## Database ID URL or Descriptions # AltName LPF_ECOLI Phe operon attenuator peptide # EcoGene EG11271 pheL # FUNCTION LPF_ECOLI This protein is involved in control of the biosynthesis of phenylalanine. # Organism LPF_ECOLI Escherichia coli (strain K12) # PIR A03593 LFECF # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LPF_ECOLI Phe operon leader peptide # RefSeq NP_417089 NC_000913.3 BLAST swissprot:LPF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LPF_ECOLI BioCyc ECOL316407:JW2579-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2579-MONOMER BioCyc EcoCyc:EG11271-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11271-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.75.9.4271 http://dx.doi.org/10.1073/pnas.75.9.4271 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M10431 http://www.ebi.ac.uk/ena/data/view/M10431 EMBL M58024 http://www.ebi.ac.uk/ena/data/view/M58024 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00314 http://www.ebi.ac.uk/ena/data/view/V00314 EchoBASE EB1250 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1250 EcoGene EG11271 http://www.ecogene.org/geneInfo.php?eg_id=EG11271 EnsemblBacteria AAC75647 http://www.ensemblgenomes.org/id/AAC75647 EnsemblBacteria AAC75647 http://www.ensemblgenomes.org/id/AAC75647 EnsemblBacteria BAE76755 http://www.ensemblgenomes.org/id/BAE76755 EnsemblBacteria BAE76755 http://www.ensemblgenomes.org/id/BAE76755 EnsemblBacteria BAE76755 http://www.ensemblgenomes.org/id/BAE76755 EnsemblBacteria b2598 http://www.ensemblgenomes.org/id/b2598 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947080 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947080 KEGG_Gene ecj:JW2579 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2579 KEGG_Gene eco:b2598 http://www.genome.jp/dbget-bin/www_bget?eco:b2598 PSORT swissprot:LPF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LPF_ECOLI PSORT-B swissprot:LPF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LPF_ECOLI PSORT2 swissprot:LPF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LPF_ECOLI Phobius swissprot:LPF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LPF_ECOLI PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2254312 http://www.ncbi.nlm.nih.gov/pubmed/2254312 PubMed 360214 http://www.ncbi.nlm.nih.gov/pubmed/360214 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417089 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417089 UniProtKB LPF_ECOLI http://www.uniprot.org/uniprot/LPF_ECOLI UniProtKB-AC P0AD72 http://www.uniprot.org/uniprot/P0AD72 charge swissprot:LPF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LPF_ECOLI epestfind swissprot:LPF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LPF_ECOLI garnier swissprot:LPF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LPF_ECOLI helixturnhelix swissprot:LPF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LPF_ECOLI hmoment swissprot:LPF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LPF_ECOLI iep swissprot:LPF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LPF_ECOLI inforesidue swissprot:LPF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LPF_ECOLI octanol swissprot:LPF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LPF_ECOLI pepcoil swissprot:LPF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LPF_ECOLI pepdigest swissprot:LPF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LPF_ECOLI pepinfo swissprot:LPF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LPF_ECOLI pepnet swissprot:LPF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LPF_ECOLI pepstats swissprot:LPF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LPF_ECOLI pepwheel swissprot:LPF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LPF_ECOLI pepwindow swissprot:LPF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LPF_ECOLI sigcleave swissprot:LPF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LPF_ECOLI ## Database ID URL or Descriptions # BioGrid 4260814 267 # CAUTION Was originally thought to be involved in delta- aminolevulinic acid biosynthesis. {ECO:0000305|PubMed 1427085}. # EcoGene EG11293 lolB # FUNCTION LOLB_ECOLI Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein. Essential for E.coli viability. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_function GO:0008565 protein transporter activity; IEA:UniProtKB-HAMAP. # GO_function GO:0071723 lipopeptide binding; IDA:EcoCyc. # GO_process GO:0010876 lipid localization; IDA:EcoCyc. # GO_process GO:0042157 lipoprotein metabolic process; IMP:EcoCyc. # GO_process GO:0044874 lipoprotein localization to outer membrane; IDA:CACAO. # GO_process GO:0051668 localization within membrane; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0008289 lipid binding # GOslim_function GO:0008565 protein transporter activity # GOslim_process GO:0008150 biological_process # HAMAP MF_00233 LolB # IntAct P61320 7 # InterPro IPR004565 OM_lipoprot_LolB # InterPro IPR029046 LolA/LolB/LppX # Organism LOLB_ECOLI Escherichia coli (strain K12) # PATRIC 32117670 VBIEscCol129921_1257 # PDB 1IWM X-ray; 1.90 A; A/B=22-207 # PDB 1IWN X-ray; 2.20 A; A=22-207 # PIR A47706 A47706 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF03550 LolB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LOLB_ECOLI Outer-membrane lipoprotein LolB # RefSeq NP_415727 NC_000913.3 # RefSeq WP_001130692 NZ_LN832404.1 # SIMILARITY Belongs to the LolB family. {ECO 0000305}. # SUBCELLULAR LOCATION LOLB_ECOLI Cell outer membrane; Lipid-anchor. # SUBUNIT LOLB_ECOLI Monomer. # SUPFAM SSF89392 SSF89392 # TCDB 1.B.46.1 the outer membrane lolab lipoprotein insertion apparatus (lolab) family # TIGRFAMs TIGR00548 lolB # eggNOG COG3017 LUCA # eggNOG ENOG4105C1U Bacteria BLAST swissprot:LOLB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LOLB_ECOLI BioCyc ECOL316407:JW1200-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1200-MONOMER BioCyc EcoCyc:EG11293-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11293-MONOMER COG COG3017 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3017 DIP DIP-35933N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35933N DOI 10.1016/0378-1119(92)90170-T http://dx.doi.org/10.1016/0378-1119(92)90170-T DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/emboj/16.23.6947 http://dx.doi.org/10.1093/emboj/16.23.6947 DOI 10.1093/emboj/cdg324 http://dx.doi.org/10.1093/emboj/cdg324 DOI 10.1099/00221287-139-2-259 http://dx.doi.org/10.1099/00221287-139-2-259 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.183.22.6538-6542.2001 http://dx.doi.org/10.1128/JB.183.22.6538-6542.2001 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D10264 http://www.ebi.ac.uk/ena/data/view/D10264 EMBL M77237 http://www.ebi.ac.uk/ena/data/view/M77237 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18555 http://www.ebi.ac.uk/ena/data/view/U18555 EchoBASE EB1270 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1270 EcoGene EG11293 http://www.ecogene.org/geneInfo.php?eg_id=EG11293 EnsemblBacteria AAC74293 http://www.ensemblgenomes.org/id/AAC74293 EnsemblBacteria AAC74293 http://www.ensemblgenomes.org/id/AAC74293 EnsemblBacteria BAA36067 http://www.ensemblgenomes.org/id/BAA36067 EnsemblBacteria BAA36067 http://www.ensemblgenomes.org/id/BAA36067 EnsemblBacteria BAA36067 http://www.ensemblgenomes.org/id/BAA36067 EnsemblBacteria b1209 http://www.ensemblgenomes.org/id/b1209 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GO_function GO:0071723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071723 GO_process GO:0010876 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010876 GO_process GO:0042157 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042157 GO_process GO:0044874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044874 GO_process GO:0051668 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051668 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0008289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289 GOslim_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 945775 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945775 HAMAP MF_00233 http://hamap.expasy.org/unirule/MF_00233 HOGENOM HOG000119778 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000119778&db=HOGENOM6 InParanoid P61320 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P61320 IntAct P61320 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P61320* InterPro IPR004565 http://www.ebi.ac.uk/interpro/entry/IPR004565 InterPro IPR029046 http://www.ebi.ac.uk/interpro/entry/IPR029046 KEGG_Gene ecj:JW1200 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1200 KEGG_Gene eco:b1209 http://www.genome.jp/dbget-bin/www_bget?eco:b1209 KEGG_Orthology KO:K02494 http://www.genome.jp/dbget-bin/www_bget?KO:K02494 MINT MINT-7259909 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-7259909 OMA YQTRGSF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YQTRGSF PDB 1IWM http://www.ebi.ac.uk/pdbe-srv/view/entry/1IWM PDB 1IWN http://www.ebi.ac.uk/pdbe-srv/view/entry/1IWN PDBsum 1IWM http://www.ebi.ac.uk/pdbsum/1IWM PDBsum 1IWN http://www.ebi.ac.uk/pdbsum/1IWN PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:LOLB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LOLB_ECOLI PSORT-B swissprot:LOLB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LOLB_ECOLI PSORT2 swissprot:LOLB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LOLB_ECOLI Pfam PF03550 http://pfam.xfam.org/family/PF03550 Phobius swissprot:LOLB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LOLB_ECOLI ProteinModelPortal P61320 http://www.proteinmodelportal.org/query/uniprot/P61320 PubMed 11673422 http://www.ncbi.nlm.nih.gov/pubmed/11673422 PubMed 12839983 http://www.ncbi.nlm.nih.gov/pubmed/12839983 PubMed 1427085 http://www.ncbi.nlm.nih.gov/pubmed/1427085 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7543480 http://www.ncbi.nlm.nih.gov/pubmed/7543480 PubMed 7679718 http://www.ncbi.nlm.nih.gov/pubmed/7679718 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9384574 http://www.ncbi.nlm.nih.gov/pubmed/9384574 RefSeq NP_415727 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415727 RefSeq WP_001130692 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001130692 SMR P61320 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P61320 STRING 511145.b1209 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1209&targetmode=cogs STRING COG3017 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3017&targetmode=cogs SUPFAM SSF89392 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF89392 TCDB 1.B.46.1 http://www.tcdb.org/search/result.php?tc=1.B.46.1 TIGRFAMs TIGR00548 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00548 UniProtKB LOLB_ECOLI http://www.uniprot.org/uniprot/LOLB_ECOLI UniProtKB-AC P61320 http://www.uniprot.org/uniprot/P61320 charge swissprot:LOLB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LOLB_ECOLI eggNOG COG3017 http://eggnogapi.embl.de/nog_data/html/tree/COG3017 eggNOG ENOG4105C1U http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C1U epestfind swissprot:LOLB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LOLB_ECOLI garnier swissprot:LOLB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LOLB_ECOLI helixturnhelix swissprot:LOLB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LOLB_ECOLI hmoment swissprot:LOLB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LOLB_ECOLI iep swissprot:LOLB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LOLB_ECOLI inforesidue swissprot:LOLB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LOLB_ECOLI octanol swissprot:LOLB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LOLB_ECOLI pepcoil swissprot:LOLB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LOLB_ECOLI pepdigest swissprot:LOLB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LOLB_ECOLI pepinfo swissprot:LOLB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LOLB_ECOLI pepnet swissprot:LOLB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LOLB_ECOLI pepstats swissprot:LOLB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LOLB_ECOLI pepwheel swissprot:LOLB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LOLB_ECOLI pepwindow swissprot:LOLB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LOLB_ECOLI sigcleave swissprot:LOLB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LOLB_ECOLI ## Database ID URL or Descriptions # BioGrid 4263291 134 # EcoGene EG14354 ylcG # INDUCTION Expressed during stationary phase (at protein level). {ECO:0000269|PubMed 19121005}. # MISCELLANEOUS YLCG_ECOLI Encoded by the cryptic lambdoid prophage DLP12. # Organism YLCG_ECOLI Escherichia coli (strain K12) # PATRIC 32116264 VBIEscCol129921_0572 # PIR S66591 S66591 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YLCG_ECOLI Uncharacterized protein YlcG # RefSeq WP_000971055 NZ_LN832404.1 # RefSeq YP_588439 NC_000913.3 # SIMILARITY To equivalent protein in phage 82. {ECO 0000305}. BLAST swissprot:YLCG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YLCG_ECOLI BioCyc ECOL316407:JW5076-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5076-MONOMER BioCyc EcoCyc:MONOMER0-2657 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2657 DOI 10.1006/jmbi.1996.0185 http://dx.doi.org/10.1006/jmbi.1996.0185 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2008.06495.x http://dx.doi.org/10.1111/j.1365-2958.2008.06495.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X92587 http://www.ebi.ac.uk/ena/data/view/X92587 EcoGene EG14354 http://www.ecogene.org/geneInfo.php?eg_id=EG14354 EnsemblBacteria ABD18639 http://www.ensemblgenomes.org/id/ABD18639 EnsemblBacteria ABD18639 http://www.ensemblgenomes.org/id/ABD18639 EnsemblBacteria BAE76326 http://www.ensemblgenomes.org/id/BAE76326 EnsemblBacteria BAE76326 http://www.ensemblgenomes.org/id/BAE76326 EnsemblBacteria BAE76326 http://www.ensemblgenomes.org/id/BAE76326 EnsemblBacteria b4509 http://www.ensemblgenomes.org/id/b4509 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1450240 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1450240 HOGENOM HOG000009382 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009382&db=HOGENOM6 KEGG_Gene ecj:JW5076 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5076 KEGG_Gene eco:b4509 http://www.genome.jp/dbget-bin/www_bget?eco:b4509 PSORT swissprot:YLCG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YLCG_ECOLI PSORT-B swissprot:YLCG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YLCG_ECOLI PSORT2 swissprot:YLCG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YLCG_ECOLI Phobius swissprot:YLCG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YLCG_ECOLI ProteinModelPortal Q47272 http://www.proteinmodelportal.org/query/uniprot/Q47272 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19121005 http://www.ncbi.nlm.nih.gov/pubmed/19121005 PubMed 8648624 http://www.ncbi.nlm.nih.gov/pubmed/8648624 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000971055 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000971055 RefSeq YP_588439 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_588439 SMR Q47272 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q47272 STRING 511145.b4509 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4509&targetmode=cogs UniProtKB YLCG_ECOLI http://www.uniprot.org/uniprot/YLCG_ECOLI UniProtKB-AC Q47272 http://www.uniprot.org/uniprot/Q47272 charge swissprot:YLCG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YLCG_ECOLI epestfind swissprot:YLCG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YLCG_ECOLI garnier swissprot:YLCG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YLCG_ECOLI helixturnhelix swissprot:YLCG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YLCG_ECOLI hmoment swissprot:YLCG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YLCG_ECOLI iep swissprot:YLCG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YLCG_ECOLI inforesidue swissprot:YLCG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YLCG_ECOLI octanol swissprot:YLCG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YLCG_ECOLI pepcoil swissprot:YLCG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YLCG_ECOLI pepdigest swissprot:YLCG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YLCG_ECOLI pepinfo swissprot:YLCG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YLCG_ECOLI pepnet swissprot:YLCG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YLCG_ECOLI pepstats swissprot:YLCG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YLCG_ECOLI pepwheel swissprot:YLCG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YLCG_ECOLI pepwindow swissprot:YLCG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YLCG_ECOLI sigcleave swissprot:YLCG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YLCG_ECOLI ## Database ID URL or Descriptions # Allergome 8365 Esc c Asparaginase # AltName ASPG2_ECOLI Colaspase # AltName ASPG2_ECOLI L-asparaginase II # AltName ASPG2_ECOLI L-asparagine amidohydrolase II # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters KM=0.115 uM for L-asparagine; # BRENDA 3.5.1 2026 # BioGrid 4259243 248 # CATALYTIC ACTIVITY L-asparagine + H(2)O = L-aspartate + NH(3). {ECO:0000269|PubMed 8706862}. # EcoGene EG10046 ansB # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_component GO:0042597 periplasmic space; ISM:EcoliWiki. # GO_function GO:0004067 asparaginase activity; IDA:EcoCyc. # GO_process GO:0006530 asparagine catabolic process; IBA:GO_Central. # GO_process GO:0051289 protein homotetramerization; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.50.1170 -; 1. # Gene3D 3.40.50.40 -; 1. # INDUCTION ASPG2_ECOLI By cAMP and anaerobiosis. # INTERACTION ASPG2_ECOLI Self; NbExp=2; IntAct=EBI-907458, EBI-907458; # IntAct P00805 7 # InterPro IPR004550 AsnASE_II # InterPro IPR006034 Asparaginase/glutaminase # InterPro IPR020827 Asparaginase/glutaminase_AS1 # InterPro IPR027473 L-asparaginase_C # InterPro IPR027474 L-asparaginase_N # InterPro IPR027475 Asparaginase/glutaminase_AS2 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00250 Alanine, aspartate and glutamate metabolism # KEGG_Pathway ko00460 Cyanoamino acid metabolism # KEGG_Pathway ko00910 Nitrogen metabolism # MISCELLANEOUS E.coli contains two L-asparaginase isoenzymes L- asparaginase I, a low-affinity enzyme located in the cytoplasm, and L-asparaginase II, a high-affinity secreted enzyme. # Organism ASPG2_ECOLI Escherichia coli (strain K12) # PATRIC 32121326 VBIEscCol129921_3051 # PDB 1HO3 X-ray; 2.50 A; A/B=23-348 # PDB 1IHD X-ray; 2.65 A; A/C=23-348 # PDB 1JAZ X-ray; 2.27 A; A/B=23-348 # PDB 1JJA X-ray; 2.30 A; A/B/C/D/E/F=23-348 # PDB 1NNS X-ray; 1.95 A; A/B=23-348 # PDB 3ECA X-ray; 2.40 A; A/B/C/D=23-348 # PDB 4ECA X-ray; 2.20 A; A/B/C/D=23-348 # PHARMACEUTICAL ASPG2_ECOLI Available under the names Crastinin (Bayer), Elspar (Merck), Kidrolase (Rhone-Poulenc) and Leunase (Kyowa). Also available as a PEG-conjugated form (Pegaspargase) under the name Oncaspar (Enzon). Used as an antineoplastic in chemotherapy. Reduces the quantity of asparagine available to cancer cells. # PIR A35132 XDEC # PIRSF PIRSF001220 L-ASNase_gatD # PRINTS PR00139 ASNGLNASE # PROSITE PS00144 ASN_GLN_ASE_1 # PROSITE PS00917 ASN_GLN_ASE_2 # PROSITE PS51732 ASN_GLN_ASE_3 # Pfam PF00710 Asparaginase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ASPG2_ECOLI L-asparaginase 2 # RefSeq NP_417432 NC_000913.3 # RefSeq WP_000394140 NZ_LN832404.1 # SIMILARITY Belongs to the asparaginase 1 family. {ECO 0000305}. # SIMILARITY Contains 1 asparaginase/glutaminase domain. {ECO:0000255|PROSITE-ProRule PRU01068}. # SMART SM00870 Asparaginase # SUBCELLULAR LOCATION ASPG2_ECOLI Periplasm. # SUBUNIT ASPG2_ECOLI Homotetramer. {ECO 0000269|PubMed 12595697, ECO 0000269|PubMed 1906013, ECO 0000269|PubMed 4561256, ECO 0000269|PubMed 8434007, ECO 0000269|PubMed 8706862}. # SUPFAM SSF53774 SSF53774 # TIGRFAMs TIGR00520 asnASE_II # WEB RESOURCE ASPG2_ECOLI Name=Worthington enzyme manual; URL="http //www.worthington-biochem.com/ASPR/"; # eggNOG COG0252 LUCA # eggNOG ENOG4105HDK Bacteria BLAST swissprot:ASPG2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ASPG2_ECOLI BioCyc ECOL316407:JW2924-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2924-MONOMER BioCyc EcoCyc:ANSB-MONOMER http://biocyc.org/getid?id=EcoCyc:ANSB-MONOMER BioCyc MetaCyc:ANSB-MONOMER http://biocyc.org/getid?id=MetaCyc:ANSB-MONOMER COG COG0252 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0252 DIP DIP-9110N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9110N DOI 10.1016/0003-9861(72)90216-0 http://dx.doi.org/10.1016/0003-9861(72)90216-0 DOI 10.1016/0014-5793(91)80723-G http://dx.doi.org/10.1016/0014-5793(91)80723-G DOI 10.1016/0014-5793(96)00660-6 http://dx.doi.org/10.1016/0014-5793(96)00660-6 DOI 10.1016/0378-1119(90)90168-Q http://dx.doi.org/10.1016/0378-1119(90)90168-Q DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.90.4.1474 http://dx.doi.org/10.1073/pnas.90.4.1474 DOI 10.1093/protein/5.8.785 http://dx.doi.org/10.1093/protein/5.8.785 DOI 10.1107/S0907444902021200 http://dx.doi.org/10.1107/S0907444902021200 DOI 10.1111/j.1432-1033.1992.tb17210.x http://dx.doi.org/10.1111/j.1432-1033.1992.tb17210.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.5.1.1 http://www.genome.jp/dbget-bin/www_bget?EC:3.5.1.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M34234 http://www.ebi.ac.uk/ena/data/view/M34234 EMBL M34277 http://www.ebi.ac.uk/ena/data/view/M34277 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 ENZYME 3.5.1.1 http://enzyme.expasy.org/EC/3.5.1.1 EchoBASE EB0044 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0044 EcoGene EG10046 http://www.ecogene.org/geneInfo.php?eg_id=EG10046 EnsemblBacteria AAC75994 http://www.ensemblgenomes.org/id/AAC75994 EnsemblBacteria AAC75994 http://www.ensemblgenomes.org/id/AAC75994 EnsemblBacteria BAE77020 http://www.ensemblgenomes.org/id/BAE77020 EnsemblBacteria BAE77020 http://www.ensemblgenomes.org/id/BAE77020 EnsemblBacteria BAE77020 http://www.ensemblgenomes.org/id/BAE77020 EnsemblBacteria b2957 http://www.ensemblgenomes.org/id/b2957 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0004067 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004067 GO_process GO:0006530 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006530 GO_process GO:0051289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051289 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.50.1170 http://www.cathdb.info/version/latest/superfamily/3.40.50.1170 Gene3D 3.40.50.40 http://www.cathdb.info/version/latest/superfamily/3.40.50.40 GeneID 947454 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947454 HOGENOM HOG000044165 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000044165&db=HOGENOM6 InParanoid P00805 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00805 IntAct P00805 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00805* IntEnz 3.5.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.1.1 InterPro IPR004550 http://www.ebi.ac.uk/interpro/entry/IPR004550 InterPro IPR006034 http://www.ebi.ac.uk/interpro/entry/IPR006034 InterPro IPR020827 http://www.ebi.ac.uk/interpro/entry/IPR020827 InterPro IPR027473 http://www.ebi.ac.uk/interpro/entry/IPR027473 InterPro IPR027474 http://www.ebi.ac.uk/interpro/entry/IPR027474 InterPro IPR027475 http://www.ebi.ac.uk/interpro/entry/IPR027475 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2924 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2924 KEGG_Gene eco:b2957 http://www.genome.jp/dbget-bin/www_bget?eco:b2957 KEGG_Orthology KO:K01424 http://www.genome.jp/dbget-bin/www_bget?KO:K01424 KEGG_Pathway ko00250 http://www.genome.jp/kegg-bin/show_pathway?ko00250 KEGG_Pathway ko00460 http://www.genome.jp/kegg-bin/show_pathway?ko00460 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Reaction rn:R00485 http://www.genome.jp/dbget-bin/www_bget?rn:R00485 OMA NFGPLGY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NFGPLGY PDB 1HO3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1HO3 PDB 1IHD http://www.ebi.ac.uk/pdbe-srv/view/entry/1IHD PDB 1JAZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1JAZ PDB 1JJA http://www.ebi.ac.uk/pdbe-srv/view/entry/1JJA PDB 1NNS http://www.ebi.ac.uk/pdbe-srv/view/entry/1NNS PDB 3ECA http://www.ebi.ac.uk/pdbe-srv/view/entry/3ECA PDB 4ECA http://www.ebi.ac.uk/pdbe-srv/view/entry/4ECA PDBsum 1HO3 http://www.ebi.ac.uk/pdbsum/1HO3 PDBsum 1IHD http://www.ebi.ac.uk/pdbsum/1IHD PDBsum 1JAZ http://www.ebi.ac.uk/pdbsum/1JAZ PDBsum 1JJA http://www.ebi.ac.uk/pdbsum/1JJA PDBsum 1NNS http://www.ebi.ac.uk/pdbsum/1NNS PDBsum 3ECA http://www.ebi.ac.uk/pdbsum/3ECA PDBsum 4ECA http://www.ebi.ac.uk/pdbsum/4ECA PRINTS PR00139 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00139 PROSITE PS00144 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00144 PROSITE PS00917 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00917 PROSITE PS51732 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51732 PSORT swissprot:ASPG2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ASPG2_ECOLI PSORT-B swissprot:ASPG2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ASPG2_ECOLI PSORT2 swissprot:ASPG2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ASPG2_ECOLI Pfam PF00710 http://pfam.xfam.org/family/PF00710 Phobius swissprot:ASPG2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ASPG2_ECOLI PhylomeDB P00805 http://phylomedb.org/?seqid=P00805 ProteinModelPortal P00805 http://www.proteinmodelportal.org/query/uniprot/P00805 PubMed 12595697 http://www.ncbi.nlm.nih.gov/pubmed/12595697 PubMed 1287659 http://www.ncbi.nlm.nih.gov/pubmed/1287659 PubMed 1521538 http://www.ncbi.nlm.nih.gov/pubmed/1521538 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1906013 http://www.ncbi.nlm.nih.gov/pubmed/1906013 PubMed 2144836 http://www.ncbi.nlm.nih.gov/pubmed/2144836 PubMed 2407723 http://www.ncbi.nlm.nih.gov/pubmed/2407723 PubMed 321449 http://www.ncbi.nlm.nih.gov/pubmed/321449 PubMed 387570 http://www.ncbi.nlm.nih.gov/pubmed/387570 PubMed 4561256 http://www.ncbi.nlm.nih.gov/pubmed/4561256 PubMed 6766894 http://www.ncbi.nlm.nih.gov/pubmed/6766894 PubMed 8434007 http://www.ncbi.nlm.nih.gov/pubmed/8434007 PubMed 8706862 http://www.ncbi.nlm.nih.gov/pubmed/8706862 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417432 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417432 RefSeq WP_000394140 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000394140 SMART SM00870 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00870 SMR P00805 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00805 STRING 511145.b2957 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2957&targetmode=cogs STRING COG0252 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0252&targetmode=cogs SUPFAM SSF53774 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53774 TIGRFAMs TIGR00520 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00520 UniProtKB ASPG2_ECOLI http://www.uniprot.org/uniprot/ASPG2_ECOLI UniProtKB-AC P00805 http://www.uniprot.org/uniprot/P00805 charge swissprot:ASPG2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ASPG2_ECOLI eggNOG COG0252 http://eggnogapi.embl.de/nog_data/html/tree/COG0252 eggNOG ENOG4105HDK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105HDK epestfind swissprot:ASPG2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ASPG2_ECOLI garnier swissprot:ASPG2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ASPG2_ECOLI helixturnhelix swissprot:ASPG2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ASPG2_ECOLI hmoment swissprot:ASPG2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ASPG2_ECOLI iep swissprot:ASPG2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ASPG2_ECOLI inforesidue swissprot:ASPG2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ASPG2_ECOLI octanol swissprot:ASPG2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ASPG2_ECOLI pepcoil swissprot:ASPG2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ASPG2_ECOLI pepdigest swissprot:ASPG2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ASPG2_ECOLI pepinfo swissprot:ASPG2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ASPG2_ECOLI pepnet swissprot:ASPG2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ASPG2_ECOLI pepstats swissprot:ASPG2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ASPG2_ECOLI pepwheel swissprot:ASPG2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ASPG2_ECOLI pepwindow swissprot:ASPG2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ASPG2_ECOLI sigcleave swissprot:ASPG2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ASPG2_ECOLI ## Database ID URL or Descriptions # AltName ZAPC_ECOLI FtsZ-associated protein C # AltName ZAPC_ECOLI Z-ring-associated protein C # BioGrid 4259444 7 # DISRUPTION PHENOTYPE Mutants divide almost normally under standard growth conditions. {ECO:0000269|PubMed 21216997}. # EcoGene EG13715 zapC # FUNCTION ZAPC_ECOLI Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ. {ECO 0000255|HAMAP-Rule MF_00906, ECO 0000269|PubMed 21216995, ECO 0000269|PubMed 21216997}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_component GO:0032153 cell division site; IDA:EcoCyc. # GO_process GO:0043093 FtsZ-dependent cytokinesis; IEA:UniProtKB-HAMAP. # GO_process GO:0051302 regulation of cell division; IMP:EcoliWiki. # GO_process GO:0090529 cell septum assembly; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_process GO:0008150 biological_process # GOslim_process GO:0022607 cellular component assembly # HAMAP MF_00906 ZapC # INTERACTION ZAPC_ECOLI Self; NbExp=3; IntAct=EBI-552519, EBI-552519; P0A9A6 ftsZ; NbExp=5; IntAct=EBI-552519, EBI-370963; # IntAct P75862 22 # InterPro IPR009809 ZapC # Organism ZAPC_ECOLI Escherichia coli (strain K12) # PATRIC 32117111 VBIEscCol129921_0980 # PDB 5E1L X-ray; 2.15 A; A=1-180 # PDB 5FO3 X-ray; 2.90 A; A/B=1-180 # PIR A64835 A64835 # PIRSF PIRSF010252 ZapC # Pfam PF07126 ZapC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Cell division protein ZapC {ECO:0000255|HAMAP-Rule MF_00906} # RefSeq NP_415466 NC_000913.3 # RefSeq WP_001295353 NZ_LN832404.1 # SIMILARITY Belongs to the ZapC family. {ECO:0000255|HAMAP- Rule MF_00906}. # SUBCELLULAR LOCATION ZAPC_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00906, ECO 0000269|PubMed 21216995, ECO 0000269|PubMed 21216997}. Note=Colocalizes with FtsZ at division sites. Localization to the Z ring is dependent on FtsZ and independent of FtsA, ZipA, ZapA or ZapB. # SUBUNIT ZAPC_ECOLI Interacts directly with FtsZ. Monomer in solution. {ECO 0000255|HAMAP-Rule MF_00906, ECO 0000269|PubMed 21216995, ECO 0000269|PubMed 21216997}. # eggNOG ENOG4108T7E Bacteria # eggNOG ENOG410YF51 LUCA BLAST swissprot:ZAPC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ZAPC_ECOLI BioCyc ECOL316407:JW5125-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5125-MONOMER BioCyc EcoCyc:G6486-MONOMER http://biocyc.org/getid?id=EcoCyc:G6486-MONOMER DIP DIP-11485N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11485N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01245-10 http://dx.doi.org/10.1128/JB.01245-10 DOI 10.1128/JB.01258-10 http://dx.doi.org/10.1128/JB.01258-10 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3479 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3479 EcoGene EG13715 http://www.ecogene.org/geneInfo.php?eg_id=EG13715 EnsemblBacteria AAC74032 http://www.ensemblgenomes.org/id/AAC74032 EnsemblBacteria AAC74032 http://www.ensemblgenomes.org/id/AAC74032 EnsemblBacteria BAA35701 http://www.ensemblgenomes.org/id/BAA35701 EnsemblBacteria BAA35701 http://www.ensemblgenomes.org/id/BAA35701 EnsemblBacteria BAA35701 http://www.ensemblgenomes.org/id/BAA35701 EnsemblBacteria b0946 http://www.ensemblgenomes.org/id/b0946 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0032153 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032153 GO_process GO:0043093 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043093 GO_process GO:0051302 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051302 GO_process GO:0090529 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090529 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GeneID 945552 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945552 HAMAP MF_00906 http://hamap.expasy.org/unirule/MF_00906 HOGENOM HOG000277864 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000277864&db=HOGENOM6 IntAct P75862 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75862* InterPro IPR009809 http://www.ebi.ac.uk/interpro/entry/IPR009809 KEGG_Gene ecj:JW5125 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5125 KEGG_Gene eco:b0946 http://www.genome.jp/dbget-bin/www_bget?eco:b0946 MINT MINT-1227819 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1227819 OMA DNWRWYF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DNWRWYF PDB 5E1L http://www.ebi.ac.uk/pdbe-srv/view/entry/5E1L PDB 5FO3 http://www.ebi.ac.uk/pdbe-srv/view/entry/5FO3 PDBsum 5E1L http://www.ebi.ac.uk/pdbsum/5E1L PDBsum 5FO3 http://www.ebi.ac.uk/pdbsum/5FO3 PSORT swissprot:ZAPC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ZAPC_ECOLI PSORT-B swissprot:ZAPC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ZAPC_ECOLI PSORT2 swissprot:ZAPC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ZAPC_ECOLI Pfam PF07126 http://pfam.xfam.org/family/PF07126 Phobius swissprot:ZAPC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ZAPC_ECOLI ProteinModelPortal P75862 http://www.proteinmodelportal.org/query/uniprot/P75862 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21216995 http://www.ncbi.nlm.nih.gov/pubmed/21216995 PubMed 21216997 http://www.ncbi.nlm.nih.gov/pubmed/21216997 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415466 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415466 RefSeq WP_001295353 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295353 SMR P75862 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75862 STRING 511145.b0946 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0946&targetmode=cogs UniProtKB ZAPC_ECOLI http://www.uniprot.org/uniprot/ZAPC_ECOLI UniProtKB-AC P75862 http://www.uniprot.org/uniprot/P75862 charge swissprot:ZAPC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ZAPC_ECOLI eggNOG ENOG4108T7E http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108T7E eggNOG ENOG410YF51 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YF51 epestfind swissprot:ZAPC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ZAPC_ECOLI garnier swissprot:ZAPC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ZAPC_ECOLI helixturnhelix swissprot:ZAPC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ZAPC_ECOLI hmoment swissprot:ZAPC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ZAPC_ECOLI iep swissprot:ZAPC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ZAPC_ECOLI inforesidue swissprot:ZAPC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ZAPC_ECOLI octanol swissprot:ZAPC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ZAPC_ECOLI pepcoil swissprot:ZAPC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ZAPC_ECOLI pepdigest swissprot:ZAPC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ZAPC_ECOLI pepinfo swissprot:ZAPC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ZAPC_ECOLI pepnet swissprot:ZAPC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ZAPC_ECOLI pepstats swissprot:ZAPC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ZAPC_ECOLI pepwheel swissprot:ZAPC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ZAPC_ECOLI pepwindow swissprot:ZAPC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ZAPC_ECOLI sigcleave swissprot:ZAPC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ZAPC_ECOLI ## Database ID URL or Descriptions # AltName NAGK_ECOLI GlcNAc kinase # BIOPHYSICOCHEMICAL PROPERTIES NAGK_ECOLI Kinetic parameters KM=342 uM for GlcNAc (at 37 degrees Celsius and pH 7.5) {ECO 0000269|PubMed 15157072, ECO 0000269|PubMed 15489439}; KM=896 uM for ATP (at 37 degrees Celsius and pH 7.5) {ECO 0000269|PubMed 15157072, ECO 0000269|PubMed 15489439}; KM=37 mM for glucose (at 37 degrees Celsius and pH 7.5) {ECO 0000269|PubMed 15157072, ECO 0000269|PubMed 15489439}; KM=3.4 mM for ATP (at 25 degrees Celsius and pH 7.6) {ECO 0000269|PubMed 15157072, ECO 0000269|PubMed 15489439}; KM=3.8 mM for glucose (at 25 degrees Celsius and pH 7.6) {ECO 0000269|PubMed 15157072, ECO 0000269|PubMed 15489439}; Vmax=118 umol/min/mg enzyme with GlcNAc as substrate (at 37 degrees Celsius and pH 7.5) {ECO 0000269|PubMed 15157072, ECO 0000269|PubMed 15489439}; Vmax=24 umol/min/mg enzyme with glucose as substrate (at 37 degrees Celsius and pH 7.5) {ECO 0000269|PubMed 15157072, ECO 0000269|PubMed 15489439}; pH dependence Active from pH 6.5 to 10. {ECO 0000269|PubMed 15489439}; # BioGrid 4260083 7 # CATALYTIC ACTIVITY ATP + N-acetyl-D-glucosamine = ADP + N-acetyl- D-glucosamine 6-phosphate. {ECO:0000269|PubMed 15489439}. # ENZYME REGULATION Strongly inhibited by ADP. {ECO:0000269|PubMed 15489439}. # EcoGene EG13442 nagK # FUNCTION NAGK_ECOLI Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. Has also low level glucokinase activity in vitro. {ECO 0000269|PubMed 15489439}. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008270 zinc ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0045127 N-acetylglucosamine kinase activity; IDA:EcoCyc. # GO_process GO:0006044 N-acetylglucosamine metabolic process; IEA:UniProtKB-HAMAP. # GO_process GO:0009254 peptidoglycan turnover; IEA:UniProtKB-HAMAP. # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # HAMAP MF_01271 GlcNAc_kinase # IntAct P75959 10 # InterPro IPR000600 ROK # InterPro IPR023505 N-acetyl-D-glucosamine_kinase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00520 Amino sugar and nucleotide sugar metabolism # Organism NAGK_ECOLI Escherichia coli (strain K12) # PATHWAY NAGK_ECOLI Cell wall biogenesis; peptidoglycan recycling. # PATRIC 32117485 VBIEscCol129921_1165 # PIR D64856 D64856 # PROSITE PS01125 ROK # Pfam PF00480 ROK # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NAGK_ECOLI N-acetyl-D-glucosamine kinase # RefSeq NP_415637 NC_000913.3 # RefSeq WP_000291270 NZ_LN832404.1 # SIMILARITY Belongs to the ROK (NagC/XylR) family. NagK subfamily. {ECO 0000305}. # eggNOG COG1940 LUCA # eggNOG ENOG4105EZX Bacteria BLAST swissprot:NAGK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NAGK_ECOLI BioCyc ECOL316407:JW1105-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1105-MONOMER BioCyc EcoCyc:G6576-MONOMER http://biocyc.org/getid?id=EcoCyc:G6576-MONOMER BioCyc MetaCyc:G6576-MONOMER http://biocyc.org/getid?id=MetaCyc:G6576-MONOMER DIP DIP-11548N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11548N DOI 10.1021/bi049424m http://dx.doi.org/10.1021/bi049424m DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.186.21.7273-7279.2004 http://dx.doi.org/10.1128/JB.186.21.7273-7279.2004 EC_number EC:2.7.1.59 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.59 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.59 http://enzyme.expasy.org/EC/2.7.1.59 EchoBASE EB3216 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3216 EcoGene EG13442 http://www.ecogene.org/geneInfo.php?eg_id=EG13442 EnsemblBacteria AAC74203 http://www.ensemblgenomes.org/id/AAC74203 EnsemblBacteria AAC74203 http://www.ensemblgenomes.org/id/AAC74203 EnsemblBacteria BAA35939 http://www.ensemblgenomes.org/id/BAA35939 EnsemblBacteria BAA35939 http://www.ensemblgenomes.org/id/BAA35939 EnsemblBacteria BAA35939 http://www.ensemblgenomes.org/id/BAA35939 EnsemblBacteria b1119 http://www.ensemblgenomes.org/id/b1119 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0045127 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045127 GO_process GO:0006044 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006044 GO_process GO:0009254 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009254 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 945664 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945664 HAMAP MF_01271 http://hamap.expasy.org/unirule/MF_01271 HOGENOM HOG000150087 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000150087&db=HOGENOM6 InParanoid P75959 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75959 IntAct P75959 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75959* IntEnz 2.7.1.59 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.59 InterPro IPR000600 http://www.ebi.ac.uk/interpro/entry/IPR000600 InterPro IPR023505 http://www.ebi.ac.uk/interpro/entry/IPR023505 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1105 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1105 KEGG_Gene eco:b1119 http://www.genome.jp/dbget-bin/www_bget?eco:b1119 KEGG_Orthology KO:K00884 http://www.genome.jp/dbget-bin/www_bget?KO:K00884 KEGG_Pathway ko00520 http://www.genome.jp/kegg-bin/show_pathway?ko00520 KEGG_Reaction rn:R01201 http://www.genome.jp/dbget-bin/www_bget?rn:R01201 MINT MINT-1274945 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1274945 OMA CFVLSEA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CFVLSEA PROSITE PS01125 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01125 PSORT swissprot:NAGK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NAGK_ECOLI PSORT-B swissprot:NAGK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NAGK_ECOLI PSORT2 swissprot:NAGK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NAGK_ECOLI Pfam PF00480 http://pfam.xfam.org/family/PF00480 Phobius swissprot:NAGK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NAGK_ECOLI PhylomeDB P75959 http://phylomedb.org/?seqid=P75959 ProteinModelPortal P75959 http://www.proteinmodelportal.org/query/uniprot/P75959 PubMed 15157072 http://www.ncbi.nlm.nih.gov/pubmed/15157072 PubMed 15489439 http://www.ncbi.nlm.nih.gov/pubmed/15489439 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415637 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415637 RefSeq WP_000291270 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000291270 SMR P75959 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75959 STRING 511145.b1119 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1119&targetmode=cogs UniProtKB NAGK_ECOLI http://www.uniprot.org/uniprot/NAGK_ECOLI UniProtKB-AC P75959 http://www.uniprot.org/uniprot/P75959 charge swissprot:NAGK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NAGK_ECOLI eggNOG COG1940 http://eggnogapi.embl.de/nog_data/html/tree/COG1940 eggNOG ENOG4105EZX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EZX epestfind swissprot:NAGK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NAGK_ECOLI garnier swissprot:NAGK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NAGK_ECOLI helixturnhelix swissprot:NAGK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NAGK_ECOLI hmoment swissprot:NAGK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NAGK_ECOLI iep swissprot:NAGK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NAGK_ECOLI inforesidue swissprot:NAGK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NAGK_ECOLI octanol swissprot:NAGK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NAGK_ECOLI pepcoil swissprot:NAGK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NAGK_ECOLI pepdigest swissprot:NAGK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NAGK_ECOLI pepinfo swissprot:NAGK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NAGK_ECOLI pepnet swissprot:NAGK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NAGK_ECOLI pepstats swissprot:NAGK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NAGK_ECOLI pepwheel swissprot:NAGK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NAGK_ECOLI pepwindow swissprot:NAGK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NAGK_ECOLI sigcleave swissprot:NAGK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NAGK_ECOLI ## Database ID URL or Descriptions # BioGrid 4262545 6 # CAZy GH73 Glycoside Hydrolase Family 73 # EcoGene EG11360 bax # GO_function GO:0004040 amidase activity; IEA:InterPro. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_function GO:0043167 ion binding # InterPro IPR002901 MGlyc_endo_b_GlcNAc-like_dom # Organism BAX_ECOLI Escherichia coli (strain K12) # PATRIC 32122616 VBIEscCol129921_3685 # PIR S47791 S47791 # Pfam PF01832 Glucosaminidase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BAX_ECOLI Protein bax # RefSeq WP_001297957 NZ_LN832404.1 # RefSeq YP_026230 NC_000913.3 # SMART SM00047 LYZ2 # eggNOG COG2992 LUCA # eggNOG ENOG4108UR8 Bacteria BLAST swissprot:BAX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BAX_ECOLI BioCyc ECOL316407:JW5653-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5653-MONOMER BioCyc EcoCyc:EG11360-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11360-MONOMER COG CAZy: http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=CAZy: COG COG2992 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2992 COG GH73 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=GH73 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X58994 http://www.ebi.ac.uk/ena/data/view/X58994 EchoBASE EB1335 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1335 EcoGene EG11360 http://www.ecogene.org/geneInfo.php?eg_id=EG11360 EnsemblBacteria AAT48192 http://www.ensemblgenomes.org/id/AAT48192 EnsemblBacteria AAT48192 http://www.ensemblgenomes.org/id/AAT48192 EnsemblBacteria BAE77723 http://www.ensemblgenomes.org/id/BAE77723 EnsemblBacteria BAE77723 http://www.ensemblgenomes.org/id/BAE77723 EnsemblBacteria BAE77723 http://www.ensemblgenomes.org/id/BAE77723 EnsemblBacteria b3570 http://www.ensemblgenomes.org/id/b3570 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004040 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004040 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GeneID 948089 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948089 HOGENOM HOG000126058 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126058&db=HOGENOM6 InParanoid P27297 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P27297 InterPro IPR002901 http://www.ebi.ac.uk/interpro/entry/IPR002901 KEGG_Gene ecj:JW5653 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5653 KEGG_Gene eco:b3570 http://www.genome.jp/dbget-bin/www_bget?eco:b3570 KEGG_Orthology KO:K03796 http://www.genome.jp/dbget-bin/www_bget?KO:K03796 OMA NLFGMRC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NLFGMRC PSORT swissprot:BAX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BAX_ECOLI PSORT-B swissprot:BAX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BAX_ECOLI PSORT2 swissprot:BAX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BAX_ECOLI Pfam PF01832 http://pfam.xfam.org/family/PF01832 Phobius swissprot:BAX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BAX_ECOLI ProteinModelPortal P27297 http://www.proteinmodelportal.org/query/uniprot/P27297 PubMed 1544897 http://www.ncbi.nlm.nih.gov/pubmed/1544897 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001297957 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001297957 RefSeq YP_026230 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026230 SMART SM00047 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00047 SMR P27297 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P27297 STRING 511145.b3570 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3570&targetmode=cogs STRING CAZy: http://string-db.org/newstring_cgi/show_network_section.pl?identifier=CAZy:&targetmode=cogs STRING COG2992 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2992&targetmode=cogs STRING GH73 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=GH73&targetmode=cogs UniProtKB BAX_ECOLI http://www.uniprot.org/uniprot/BAX_ECOLI UniProtKB-AC P27297 http://www.uniprot.org/uniprot/P27297 charge swissprot:BAX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BAX_ECOLI eggNOG COG2992 http://eggnogapi.embl.de/nog_data/html/tree/COG2992 eggNOG ENOG4108UR8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UR8 epestfind swissprot:BAX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BAX_ECOLI garnier swissprot:BAX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BAX_ECOLI helixturnhelix swissprot:BAX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BAX_ECOLI hmoment swissprot:BAX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BAX_ECOLI iep swissprot:BAX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BAX_ECOLI inforesidue swissprot:BAX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BAX_ECOLI octanol swissprot:BAX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BAX_ECOLI pepcoil swissprot:BAX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BAX_ECOLI pepdigest swissprot:BAX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BAX_ECOLI pepinfo swissprot:BAX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BAX_ECOLI pepnet swissprot:BAX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BAX_ECOLI pepstats swissprot:BAX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BAX_ECOLI pepwheel swissprot:BAX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BAX_ECOLI pepwindow swissprot:BAX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BAX_ECOLI sigcleave swissprot:BAX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BAX_ECOLI ## Database ID URL or Descriptions # BioGrid 4263296 17 # CATALYTIC ACTIVITY (R,R)-tartrate = oxaloacetate + H(2)O. {ECO:0000269|PubMed 8371115}. # COFACTOR Name=iron-sulfur cluster; Xref=ChEBI:CHEBI 30408; # EcoGene EG11168 ttdA # GO_function GO:0008730 L(+)-tartrate dehydratase activity; IEA:UniProtKB-EC. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0044010 single-species biofilm formation; IMP:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # INDUCTION Induced by tartrate, via TtdR. {ECO:0000269|PubMed 16804186}. # INTERACTION TTDA_ECOLI P0ACL0 glpR; NbExp=2; IntAct=EBI-1113137, EBI-1123685; # IntAct P05847 6 # InterPro IPR004646 Fe-S_hydro-lyase_TtdA-typ_cat # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00630 Glyoxylate and dicarboxylate metabolism # Organism TTDA_ECOLI Escherichia coli (strain K12) # PATRIC 32121536 VBIEscCol129921_3155 # PIR C65094 QQECRT # Pfam PF05681 Fumerase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TTDA_ECOLI L(+)-tartrate dehydratase subunit alpha # RefSeq NP_417533 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA72573.1; Type=Frameshift; Positions=198; Evidence={ECO 0000305}; # SIMILARITY Belongs to the class-I fumarase family. {ECO 0000305}. # SUBUNIT Tetramer of two alpha and two beta subunits. {ECO:0000305|PubMed 8371115}. # TIGRFAMs TIGR00722 ttdA_fumA_fumB # eggNOG COG1951 LUCA # eggNOG ENOG4106DSS Bacteria BLAST swissprot:TTDA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TTDA_ECOLI BioCyc ECOL316407:JW3033-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3033-MONOMER BioCyc EcoCyc:TTDA-MONOMER http://biocyc.org/getid?id=EcoCyc:TTDA-MONOMER BioCyc MetaCyc:TTDA-MONOMER http://biocyc.org/getid?id=MetaCyc:TTDA-MONOMER COG COG1951 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1951 DOI 10.1016/0378-1119(87)90303-9 http://dx.doi.org/10.1016/0378-1119(87)90303-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1099/00221287-139-7-1523 http://dx.doi.org/10.1099/00221287-139-7-1523 DOI 10.1099/mic.0.28753-0 http://dx.doi.org/10.1099/mic.0.28753-0 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.1.32 http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.32 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L14781 http://www.ebi.ac.uk/ena/data/view/L14781 EMBL M16194 http://www.ebi.ac.uk/ena/data/view/M16194 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28379 http://www.ebi.ac.uk/ena/data/view/U28379 ENZYME 4.2.1.32 http://enzyme.expasy.org/EC/4.2.1.32 EchoBASE EB1156 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1156 EcoGene EG11168 http://www.ecogene.org/geneInfo.php?eg_id=EG11168 EnsemblBacteria AAC76097 http://www.ensemblgenomes.org/id/AAC76097 EnsemblBacteria AAC76097 http://www.ensemblgenomes.org/id/AAC76097 EnsemblBacteria BAE77112 http://www.ensemblgenomes.org/id/BAE77112 EnsemblBacteria BAE77112 http://www.ensemblgenomes.org/id/BAE77112 EnsemblBacteria BAE77112 http://www.ensemblgenomes.org/id/BAE77112 EnsemblBacteria b3061 http://www.ensemblgenomes.org/id/b3061 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008730 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008730 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0044010 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044010 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 947565 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947565 HOGENOM HOG000225707 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000225707&db=HOGENOM6 InParanoid P05847 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P05847 IntAct P05847 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P05847* IntEnz 4.2.1.32 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.32 InterPro IPR004646 http://www.ebi.ac.uk/interpro/entry/IPR004646 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3033 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3033 KEGG_Gene eco:b3061 http://www.genome.jp/dbget-bin/www_bget?eco:b3061 KEGG_Orthology KO:K03779 http://www.genome.jp/dbget-bin/www_bget?KO:K03779 KEGG_Pathway ko00630 http://www.genome.jp/kegg-bin/show_pathway?ko00630 KEGG_Reaction rn:R00339 http://www.genome.jp/dbget-bin/www_bget?rn:R00339 OMA IQCWANR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IQCWANR PSORT swissprot:TTDA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TTDA_ECOLI PSORT-B swissprot:TTDA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TTDA_ECOLI PSORT2 swissprot:TTDA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TTDA_ECOLI Pfam PF05681 http://pfam.xfam.org/family/PF05681 Phobius swissprot:TTDA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TTDA_ECOLI PhylomeDB P05847 http://phylomedb.org/?seqid=P05847 ProteinModelPortal P05847 http://www.proteinmodelportal.org/query/uniprot/P05847 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16804186 http://www.ncbi.nlm.nih.gov/pubmed/16804186 PubMed 3297921 http://www.ncbi.nlm.nih.gov/pubmed/3297921 PubMed 8371115 http://www.ncbi.nlm.nih.gov/pubmed/8371115 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417533 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417533 STRING 511145.b3061 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3061&targetmode=cogs STRING COG1951 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1951&targetmode=cogs TIGRFAMs TIGR00722 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00722 UniProtKB TTDA_ECOLI http://www.uniprot.org/uniprot/TTDA_ECOLI UniProtKB-AC P05847 http://www.uniprot.org/uniprot/P05847 charge swissprot:TTDA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TTDA_ECOLI eggNOG COG1951 http://eggnogapi.embl.de/nog_data/html/tree/COG1951 eggNOG ENOG4106DSS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106DSS epestfind swissprot:TTDA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TTDA_ECOLI garnier swissprot:TTDA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TTDA_ECOLI helixturnhelix swissprot:TTDA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TTDA_ECOLI hmoment swissprot:TTDA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TTDA_ECOLI iep swissprot:TTDA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TTDA_ECOLI inforesidue swissprot:TTDA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TTDA_ECOLI octanol swissprot:TTDA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TTDA_ECOLI pepcoil swissprot:TTDA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TTDA_ECOLI pepdigest swissprot:TTDA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TTDA_ECOLI pepinfo swissprot:TTDA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TTDA_ECOLI pepnet swissprot:TTDA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TTDA_ECOLI pepstats swissprot:TTDA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TTDA_ECOLI pepwheel swissprot:TTDA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TTDA_ECOLI pepwindow swissprot:TTDA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TTDA_ECOLI sigcleave swissprot:TTDA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TTDA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261097 6 # EcoGene EG10284 fdhE # FUNCTION FDHE_ECOLI Necessary for formate dehydrogenase activity. # GO_component GO:0005737 cytoplasm; IDA:EcoCyc. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008199 ferric iron binding; IDA:EcoCyc. # GO_process GO:0051604 protein maturation; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0043167 ion binding # GOslim_process GO:0051604 protein maturation # Gene3D 3.90.1670.10 -; 1. # HAMAP MF_00611 FdeH # INTERACTION FDHE_ECOLI P24183 fdnG; NbExp=4; IntAct=EBI-550129, EBI-550115; P32176 fdoG; NbExp=3; IntAct=EBI-550129, EBI-368676; # IntAct P13024 23 # InterPro IPR006452 Formate_DH_accessory # InterPro IPR024064 FdhE-like # Organism FDHE_ECOLI Escherichia coli (strain K12) # PATRIC 32123289 VBIEscCol129921_4005 # PIR S40835 S40835 # PIRSF PIRSF018296 Format_dh_formtn # Pfam PF04216 FdhE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FDHE_ECOLI Protein FdhE # RefSeq NP_418327 NC_000913.3 # RefSeq WP_000027703 NZ_LN832404.1 # SIMILARITY Belongs to the FdhE family. {ECO 0000305}. # SUBCELLULAR LOCATION FDHE_ECOLI Cytoplasm. # SUPFAM SSF144020 SSF144020 # TIGRFAMs TIGR01562 FdhE # eggNOG COG3058 LUCA # eggNOG ENOG4105F46 Bacteria BLAST swissprot:FDHE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FDHE_ECOLI BioCyc ECOL316407:JW3862-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3862-MONOMER BioCyc EcoCyc:EG10284-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10284-MONOMER COG COG3058 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3058 DIP DIP-9571N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9571N DOI 10.1016/0378-1119(91)90023-5 http://dx.doi.org/10.1016/0378-1119(91)90023-5 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X16016 http://www.ebi.ac.uk/ena/data/view/X16016 EchoBASE EB0280 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0280 EcoGene EG10284 http://www.ecogene.org/geneInfo.php?eg_id=EG10284 EnsemblBacteria AAD13453 http://www.ensemblgenomes.org/id/AAD13453 EnsemblBacteria AAD13453 http://www.ensemblgenomes.org/id/AAD13453 EnsemblBacteria BAE77418 http://www.ensemblgenomes.org/id/BAE77418 EnsemblBacteria BAE77418 http://www.ensemblgenomes.org/id/BAE77418 EnsemblBacteria BAE77418 http://www.ensemblgenomes.org/id/BAE77418 EnsemblBacteria b3891 http://www.ensemblgenomes.org/id/b3891 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008199 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008199 GO_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 Gene3D 3.90.1670.10 http://www.cathdb.info/version/latest/superfamily/3.90.1670.10 GeneID 948384 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948384 HAMAP MF_00611 http://hamap.expasy.org/unirule/MF_00611 HOGENOM HOG000163613 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000163613&db=HOGENOM6 InParanoid P13024 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P13024 IntAct P13024 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P13024* InterPro IPR006452 http://www.ebi.ac.uk/interpro/entry/IPR006452 InterPro IPR024064 http://www.ebi.ac.uk/interpro/entry/IPR024064 KEGG_Gene ecj:JW3862 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3862 KEGG_Gene eco:b3891 http://www.genome.jp/dbget-bin/www_bget?eco:b3891 KEGG_Orthology KO:K02380 http://www.genome.jp/dbget-bin/www_bget?KO:K02380 MINT MINT-1292317 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1292317 OMA LDQPGLC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LDQPGLC PSORT swissprot:FDHE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FDHE_ECOLI PSORT-B swissprot:FDHE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FDHE_ECOLI PSORT2 swissprot:FDHE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FDHE_ECOLI Pfam PF04216 http://pfam.xfam.org/family/PF04216 Phobius swissprot:FDHE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FDHE_ECOLI PhylomeDB P13024 http://phylomedb.org/?seqid=P13024 ProteinModelPortal P13024 http://www.proteinmodelportal.org/query/uniprot/P13024 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1995428 http://www.ncbi.nlm.nih.gov/pubmed/1995428 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418327 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418327 RefSeq WP_000027703 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000027703 SMR P13024 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P13024 STRING 511145.b3891 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3891&targetmode=cogs STRING COG3058 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3058&targetmode=cogs SUPFAM SSF144020 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF144020 TIGRFAMs TIGR01562 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01562 UniProtKB FDHE_ECOLI http://www.uniprot.org/uniprot/FDHE_ECOLI UniProtKB-AC P13024 http://www.uniprot.org/uniprot/P13024 charge swissprot:FDHE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FDHE_ECOLI eggNOG COG3058 http://eggnogapi.embl.de/nog_data/html/tree/COG3058 eggNOG ENOG4105F46 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F46 epestfind swissprot:FDHE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FDHE_ECOLI garnier swissprot:FDHE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FDHE_ECOLI helixturnhelix swissprot:FDHE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FDHE_ECOLI hmoment swissprot:FDHE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FDHE_ECOLI iep swissprot:FDHE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FDHE_ECOLI inforesidue swissprot:FDHE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FDHE_ECOLI octanol swissprot:FDHE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FDHE_ECOLI pepcoil swissprot:FDHE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FDHE_ECOLI pepdigest swissprot:FDHE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FDHE_ECOLI pepinfo swissprot:FDHE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FDHE_ECOLI pepnet swissprot:FDHE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FDHE_ECOLI pepstats swissprot:FDHE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FDHE_ECOLI pepwheel swissprot:FDHE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FDHE_ECOLI pepwindow swissprot:FDHE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FDHE_ECOLI sigcleave swissprot:FDHE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FDHE_ECOLI ## Database ID URL or Descriptions # AltName FEPA_ECOLI Enterobactin outer-membrane receptor # BioGrid 4263074 237 # EcoGene EG10293 fepA # FUNCTION FEPA_ECOLI This protein is involved in the initial step of iron uptake by binding ferrienterobactin (Fe-ENT), an iron chelatin siderophore that allows E.coli to extract iron from the environment. FepA also acts as a receptor for colicins B and D. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_component GO:0045203 integral component of cell outer membrane; IDA:EcoCyc. # GO_function GO:0005506 iron ion binding; IEA:InterPro. # GO_function GO:0015620 ferric-enterobactin transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0022834 ligand-gated channel activity; IMP:EcoCyc. # GO_function GO:0042912 colicin transmembrane transporter activity; IDA:EcoCyc. # GO_process GO:0015685 ferric-enterobactin transport; IDA:EcoCyc. # GO_process GO:0033214 iron assimilation by chelation and transport; IMP:EcoCyc. # GO_process GO:0042914 colicin transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0008565 protein transporter activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # GOslim_process GO:0042592 homeostatic process # Gene3D 2.170.130.10 -; 1. # Gene3D 2.40.170.20 -; 1. # INDUCTION Induced 1.9-fold by hydroxyurea. {ECO:0000269|PubMed 20005847}. # INTERACTION FEPA_ECOLI P02929 tonB; NbExp=2; IntAct=EBI-6400027, EBI-6399993; # InterPro IPR000531 TonB-dep_rcpt_b-brl # InterPro IPR010105 TonB_sidphr_rcpt # InterPro IPR010916 TonB_box_CS # InterPro IPR010917 TonB_rcpt_CS # InterPro IPR012910 Plug_dom # KEGG_Brite ko02000 Transporters # Organism FEPA_ECOLI Escherichia coli (strain K12) # PATRIC 32116338 VBIEscCol129921_0609 # PDB 1FEP X-ray; 2.40 A; A=23-746 # PIR F64791 QRECFC # PROSITE PS00430 TONB_DEPENDENT_REC_1 # PROSITE PS01156 TONB_DEPENDENT_REC_2 # Pfam PF00593 TonB_dep_Rec # Pfam PF07715 Plug # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FEPA_ECOLI Ferrienterobactin receptor # RefSeq NP_415116 NC_000913.3 # RefSeq WP_001034943 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40783.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the TonB-dependent receptor family. {ECO 0000305}. # SUBCELLULAR LOCATION FEPA_ECOLI Cell outer membrane; Multi-pass membrane protein. # TCDB 1.B.14.1.22 the outer membrane receptor (omr) family # TIGRFAMs TIGR01783 TonB-siderophor # eggNOG COG4771 LUCA # eggNOG ENOG4107RNH Bacteria BLAST swissprot:FEPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FEPA_ECOLI BioCyc ECOL316407:JW5086-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5086-MONOMER BioCyc EcoCyc:EG10293-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10293-MONOMER BioCyc MetaCyc:EG10293-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10293-MONOMER COG COG4771 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4771 DIP DIP-9592N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9592N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/4931 http://dx.doi.org/10.1038/4931 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1989.tb00224.x http://dx.doi.org/10.1111/j.1365-2958.1989.tb00224.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J04216 http://www.ebi.ac.uk/ena/data/view/J04216 EMBL M13748 http://www.ebi.ac.uk/ena/data/view/M13748 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB0289 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0289 EcoGene EG10293 http://www.ecogene.org/geneInfo.php?eg_id=EG10293 EnsemblBacteria AAC73685 http://www.ensemblgenomes.org/id/AAC73685 EnsemblBacteria AAC73685 http://www.ensemblgenomes.org/id/AAC73685 EnsemblBacteria BAA35225 http://www.ensemblgenomes.org/id/BAA35225 EnsemblBacteria BAA35225 http://www.ensemblgenomes.org/id/BAA35225 EnsemblBacteria BAA35225 http://www.ensemblgenomes.org/id/BAA35225 EnsemblBacteria b0584 http://www.ensemblgenomes.org/id/b0584 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0045203 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045203 GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0015620 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015620 GO_function GO:0022834 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022834 GO_function GO:0042912 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042912 GO_process GO:0015685 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015685 GO_process GO:0033214 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033214 GO_process GO:0042914 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042914 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 Gene3D 2.170.130.10 http://www.cathdb.info/version/latest/superfamily/2.170.130.10 Gene3D 2.40.170.20 http://www.cathdb.info/version/latest/superfamily/2.40.170.20 GeneID 945193 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945193 HOGENOM HOG000276827 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276827&db=HOGENOM6 InParanoid P05825 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P05825 IntAct P05825 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P05825* InterPro IPR000531 http://www.ebi.ac.uk/interpro/entry/IPR000531 InterPro IPR010105 http://www.ebi.ac.uk/interpro/entry/IPR010105 InterPro IPR010916 http://www.ebi.ac.uk/interpro/entry/IPR010916 InterPro IPR010917 http://www.ebi.ac.uk/interpro/entry/IPR010917 InterPro IPR012910 http://www.ebi.ac.uk/interpro/entry/IPR012910 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5086 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5086 KEGG_Gene eco:b0584 http://www.genome.jp/dbget-bin/www_bget?eco:b0584 KEGG_Orthology KO:K16089 http://www.genome.jp/dbget-bin/www_bget?KO:K16089 OMA YRQNYAV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YRQNYAV PDB 1FEP http://www.ebi.ac.uk/pdbe-srv/view/entry/1FEP PDBsum 1FEP http://www.ebi.ac.uk/pdbsum/1FEP PROSITE PS00430 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00430 PROSITE PS01156 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01156 PSORT swissprot:FEPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FEPA_ECOLI PSORT-B swissprot:FEPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FEPA_ECOLI PSORT2 swissprot:FEPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FEPA_ECOLI Pfam PF00593 http://pfam.xfam.org/family/PF00593 Pfam PF07715 http://pfam.xfam.org/family/PF07715 Phobius swissprot:FEPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FEPA_ECOLI PhylomeDB P05825 http://phylomedb.org/?seqid=P05825 ProteinModelPortal P05825 http://www.proteinmodelportal.org/query/uniprot/P05825 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 2201687 http://www.ncbi.nlm.nih.gov/pubmed/2201687 PubMed 2526281 http://www.ncbi.nlm.nih.gov/pubmed/2526281 PubMed 2974033 http://www.ncbi.nlm.nih.gov/pubmed/2974033 PubMed 3015941 http://www.ncbi.nlm.nih.gov/pubmed/3015941 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9886293 http://www.ncbi.nlm.nih.gov/pubmed/9886293 RefSeq NP_415116 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415116 RefSeq WP_001034943 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001034943 SMR P05825 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P05825 STRING 511145.b0584 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0584&targetmode=cogs STRING COG4771 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4771&targetmode=cogs SWISS-2DPAGE P05825 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P05825 TCDB 1.B.14.1.22 http://www.tcdb.org/search/result.php?tc=1.B.14.1.22 TIGRFAMs TIGR01783 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01783 UniProtKB FEPA_ECOLI http://www.uniprot.org/uniprot/FEPA_ECOLI UniProtKB-AC P05825 http://www.uniprot.org/uniprot/P05825 charge swissprot:FEPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FEPA_ECOLI eggNOG COG4771 http://eggnogapi.embl.de/nog_data/html/tree/COG4771 eggNOG ENOG4107RNH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107RNH epestfind swissprot:FEPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FEPA_ECOLI garnier swissprot:FEPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FEPA_ECOLI helixturnhelix swissprot:FEPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FEPA_ECOLI hmoment swissprot:FEPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FEPA_ECOLI iep swissprot:FEPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FEPA_ECOLI inforesidue swissprot:FEPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FEPA_ECOLI octanol swissprot:FEPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FEPA_ECOLI pepcoil swissprot:FEPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FEPA_ECOLI pepdigest swissprot:FEPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FEPA_ECOLI pepinfo swissprot:FEPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FEPA_ECOLI pepnet swissprot:FEPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FEPA_ECOLI pepstats swissprot:FEPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FEPA_ECOLI pepwheel swissprot:FEPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FEPA_ECOLI pepwindow swissprot:FEPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FEPA_ECOLI sigcleave swissprot:FEPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FEPA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262160 6 # CDD cd01948 EAL # EcoGene EG12256 yhjK # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0004112 cyclic-nucleotide phosphodiesterase activity; IMP:EcoCyc. # GO_function GO:0004871 signal transducer activity; IEA:InterPro. # GO_process GO:0052653 3',5'-cyclic diguanylic acid metabolic process; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0004871 signal transducer activity # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.450 -; 1. # INDUCTION Expressed at 28 degrees Celsius in stationary phase. {ECO:0000269|PubMed 19332833}. # InterPro IPR000160 GGDEF_dom # InterPro IPR001633 EAL_dom # InterPro IPR003660 HAMP_dom # InterPro IPR029787 Nucleotide_cyclase # InterPro IPR033419 GAPES3 # Organism YHJK_ECOLI Escherichia coli (strain K12) # PATRIC 32122524 VBIEscCol129921_3640 # PIR S47750 S47750 # PROSITE PS50883 EAL # PROSITE PS50885 HAMP # PROSITE PS50887 GGDEF # Pfam PF00563 EAL # Pfam PF00672 HAMP # Pfam PF00990 GGDEF # Pfam PF17154 GAPES3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHJK_ECOLI Protein YhjK # RefSeq NP_417986 NC_000913.3 # SEQUENCE CAUTION Sequence=AAB18506.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAE77765.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Contains 1 EAL domain. {ECO:0000255|PROSITE- ProRule PRU00074}. # SIMILARITY Contains 1 GGDEF domain. {ECO:0000255|PROSITE- ProRule PRU00095}. # SIMILARITY Contains 1 HAMP domain. {ECO:0000255|PROSITE- ProRule PRU00102}. # SMART SM00052 EAL # SMART SM00267 GGDEF # SUBCELLULAR LOCATION YHJK_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # SUPFAM SSF141868 SSF141868 # SUPFAM SSF55073 SSF55073 # eggNOG ENOG4105BZU Bacteria # eggNOG ENOG410XNMH LUCA BLAST swissprot:YHJK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHJK_ECOLI BioCyc ECOL316407:JW5943-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5943-MONOMER BioCyc EcoCyc:EG12256-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12256-MONOMER DIP DIP-12384N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12384N DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1099/mic.0.024257-0 http://dx.doi.org/10.1099/mic.0.024257-0 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2165 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2165 EcoGene EG12256 http://www.ecogene.org/geneInfo.php?eg_id=EG12256 EnsemblBacteria AAC76554 http://www.ensemblgenomes.org/id/AAC76554 EnsemblBacteria AAC76554 http://www.ensemblgenomes.org/id/AAC76554 EnsemblBacteria BAE77765 http://www.ensemblgenomes.org/id/BAE77765 EnsemblBacteria BAE77765 http://www.ensemblgenomes.org/id/BAE77765 EnsemblBacteria BAE77765 http://www.ensemblgenomes.org/id/BAE77765 EnsemblBacteria b3529 http://www.ensemblgenomes.org/id/b3529 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0004112 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004112 GO_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GO_process GO:0052653 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052653 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.450 http://www.cathdb.info/version/latest/superfamily/3.20.20.450 GeneID 948048 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948048 HOGENOM HOG000125924 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125924&db=HOGENOM6 IntAct P37649 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37649* InterPro IPR000160 http://www.ebi.ac.uk/interpro/entry/IPR000160 InterPro IPR001633 http://www.ebi.ac.uk/interpro/entry/IPR001633 InterPro IPR003660 http://www.ebi.ac.uk/interpro/entry/IPR003660 InterPro IPR029787 http://www.ebi.ac.uk/interpro/entry/IPR029787 InterPro IPR033419 http://www.ebi.ac.uk/interpro/entry/IPR033419 KEGG_Gene ecj:JW5943 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5943 KEGG_Gene eco:b3529 http://www.genome.jp/dbget-bin/www_bget?eco:b3529 PROSITE PS50883 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50883 PROSITE PS50885 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50885 PROSITE PS50887 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50887 PSORT swissprot:YHJK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHJK_ECOLI PSORT-B swissprot:YHJK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHJK_ECOLI PSORT2 swissprot:YHJK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHJK_ECOLI Pfam PF00563 http://pfam.xfam.org/family/PF00563 Pfam PF00672 http://pfam.xfam.org/family/PF00672 Pfam PF00990 http://pfam.xfam.org/family/PF00990 Pfam PF17154 http://pfam.xfam.org/family/PF17154 Phobius swissprot:YHJK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHJK_ECOLI PhylomeDB P37649 http://phylomedb.org/?seqid=P37649 ProteinModelPortal P37649 http://www.proteinmodelportal.org/query/uniprot/P37649 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19332833 http://www.ncbi.nlm.nih.gov/pubmed/19332833 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417986 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417986 SMART SM00052 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00052 SMART SM00267 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00267 SMR P37649 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37649 STRING 511145.b3529 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3529&targetmode=cogs SUPFAM SSF141868 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF141868 SUPFAM SSF55073 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55073 UniProtKB YHJK_ECOLI http://www.uniprot.org/uniprot/YHJK_ECOLI UniProtKB-AC P37649 http://www.uniprot.org/uniprot/P37649 charge swissprot:YHJK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHJK_ECOLI eggNOG ENOG4105BZU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZU eggNOG ENOG410XNMH http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNMH epestfind swissprot:YHJK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHJK_ECOLI garnier swissprot:YHJK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHJK_ECOLI helixturnhelix swissprot:YHJK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHJK_ECOLI hmoment swissprot:YHJK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHJK_ECOLI iep swissprot:YHJK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHJK_ECOLI inforesidue swissprot:YHJK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHJK_ECOLI octanol swissprot:YHJK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHJK_ECOLI pepcoil swissprot:YHJK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHJK_ECOLI pepdigest swissprot:YHJK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHJK_ECOLI pepinfo swissprot:YHJK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHJK_ECOLI pepnet swissprot:YHJK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHJK_ECOLI pepstats swissprot:YHJK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHJK_ECOLI pepwheel swissprot:YHJK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHJK_ECOLI pepwindow swissprot:YHJK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHJK_ECOLI sigcleave swissprot:YHJK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHJK_ECOLI ## Database ID URL or Descriptions # BioGrid 4259833 13 # COFACTOR NRDR_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000250}; Note=Binds 1 zinc ion. {ECO 0000250}; # EcoGene EG11320 nrdR # FUNCTION NRDR_ECOLI Represses transcription of the class Ib RNR genes nrdHIEF but has much smaller effect on transcription of the class Ia RNR genes nrdAB and class III RNR genes nrdDG. By binding to nrdR boxes in the promoter regions to alter promoter activity, nrdR differentially regulates nrdAB, nrdHIEF and nrdD transcription in aerobic growth. {ECO 0000269|PubMed 17496099}. # GO_function GO:0003690 double-stranded DNA binding; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IMP:EcoCyc. # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # HAMAP MF_00440 NrdR # IntAct P0A8D0 18 # InterPro IPR003796 RNR_NrdR-like # InterPro IPR005144 ATP-cone_dom # KEGG_Brite ko03000 Transcription factors # Organism NRDR_ECOLI Escherichia coli (strain K12) # PATRIC 32115975 VBIEscCol129921_0429 # PIR S26200 S26200 # PROSITE PS51161 ATP_CONE # Pfam PF03477 ATP-cone # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NRDR_ECOLI Transcriptional repressor NrdR # RefSeq NP_414947 NC_000913.3 # RefSeq WP_000543535 NZ_LN832404.1 # SIMILARITY Belongs to the NrdR family. {ECO 0000305}. # SIMILARITY Contains 1 ATP-cone domain. {ECO 0000305}. # TIGRFAMs TIGR00244 TIGR00244 # eggNOG COG1327 LUCA # eggNOG ENOG4108Z11 Bacteria BLAST swissprot:NRDR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NRDR_ECOLI BioCyc ECOL316407:JW0403-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0403-MONOMER BioCyc EcoCyc:EG11320-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11320-MONOMER COG COG1327 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1327 DIP DIP-31842N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31842N DOI 10.1007/BF00538702 http://dx.doi.org/10.1007/BF00538702 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00440-07 http://dx.doi.org/10.1128/JB.00440-07 EMBL AM076828 http://www.ebi.ac.uk/ena/data/view/AM076828 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL X64395 http://www.ebi.ac.uk/ena/data/view/X64395 EchoBASE EB1296 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1296 EcoGene EG11320 http://www.ecogene.org/geneInfo.php?eg_id=EG11320 EnsemblBacteria AAC73516 http://www.ensemblgenomes.org/id/AAC73516 EnsemblBacteria AAC73516 http://www.ensemblgenomes.org/id/AAC73516 EnsemblBacteria BAE76193 http://www.ensemblgenomes.org/id/BAE76193 EnsemblBacteria BAE76193 http://www.ensemblgenomes.org/id/BAE76193 EnsemblBacteria BAE76193 http://www.ensemblgenomes.org/id/BAE76193 EnsemblBacteria b0413 http://www.ensemblgenomes.org/id/b0413 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003690 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003690 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 947437 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947437 HAMAP MF_00440 http://hamap.expasy.org/unirule/MF_00440 HOGENOM HOG000097653 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000097653&db=HOGENOM6 InParanoid P0A8D0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8D0 IntAct P0A8D0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8D0* InterPro IPR003796 http://www.ebi.ac.uk/interpro/entry/IPR003796 InterPro IPR005144 http://www.ebi.ac.uk/interpro/entry/IPR005144 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW0403 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0403 KEGG_Gene eco:b0413 http://www.genome.jp/dbget-bin/www_bget?eco:b0413 KEGG_Orthology KO:K07738 http://www.genome.jp/dbget-bin/www_bget?KO:K07738 MINT MINT-1276184 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1276184 OMA RFTTYET http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RFTTYET PROSITE PS51161 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51161 PSORT swissprot:NRDR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NRDR_ECOLI PSORT-B swissprot:NRDR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NRDR_ECOLI PSORT2 swissprot:NRDR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NRDR_ECOLI Pfam PF03477 http://pfam.xfam.org/family/PF03477 Phobius swissprot:NRDR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NRDR_ECOLI PhylomeDB P0A8D0 http://phylomedb.org/?seqid=P0A8D0 ProteinModelPortal P0A8D0 http://www.proteinmodelportal.org/query/uniprot/P0A8D0 PubMed 1406588 http://www.ncbi.nlm.nih.gov/pubmed/1406588 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17496099 http://www.ncbi.nlm.nih.gov/pubmed/17496099 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414947 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414947 RefSeq WP_000543535 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000543535 STRING 511145.b0413 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0413&targetmode=cogs STRING COG1327 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1327&targetmode=cogs TIGRFAMs TIGR00244 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00244 UniProtKB NRDR_ECOLI http://www.uniprot.org/uniprot/NRDR_ECOLI UniProtKB-AC P0A8D0 http://www.uniprot.org/uniprot/P0A8D0 charge swissprot:NRDR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NRDR_ECOLI eggNOG COG1327 http://eggnogapi.embl.de/nog_data/html/tree/COG1327 eggNOG ENOG4108Z11 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Z11 epestfind swissprot:NRDR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NRDR_ECOLI garnier swissprot:NRDR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NRDR_ECOLI helixturnhelix swissprot:NRDR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NRDR_ECOLI hmoment swissprot:NRDR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NRDR_ECOLI iep swissprot:NRDR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NRDR_ECOLI inforesidue swissprot:NRDR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NRDR_ECOLI octanol swissprot:NRDR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NRDR_ECOLI pepcoil swissprot:NRDR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NRDR_ECOLI pepdigest swissprot:NRDR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NRDR_ECOLI pepinfo swissprot:NRDR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NRDR_ECOLI pepnet swissprot:NRDR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NRDR_ECOLI pepstats swissprot:NRDR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NRDR_ECOLI pepwheel swissprot:NRDR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NRDR_ECOLI pepwindow swissprot:NRDR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NRDR_ECOLI sigcleave swissprot:NRDR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NRDR_ECOLI ## Database ID URL or Descriptions # BioGrid 4260750 6 # CAUTION Was originally thought to be the ileR repressor for the Thr and Ilv operons. {ECO:0000305|PubMed 3525538}. # FUNCTION Y4223_ECOLI Could be a multicopy suppressor of the ileR regulatory mutation. # Organism Y4223_ECOLI Escherichia coli (strain K12) # PIR S56449 RPECIL # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Y4223_ECOLI Putative uncharacterized protein b4223 BLAST swissprot:Y4223_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:Y4223_ECOLI BioCyc ECOL316407:JW4182-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4182-MONOMER BioCyc EcoCyc:EG11213-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11213-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M14018 http://www.ebi.ac.uk/ena/data/view/M14018 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EnsemblBacteria BAE78224 http://www.ensemblgenomes.org/id/BAE78224 EnsemblBacteria BAE78224 http://www.ensemblgenomes.org/id/BAE78224 EnsemblBacteria BAE78224 http://www.ensemblgenomes.org/id/BAE78224 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv IntAct P08339 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P08339* KEGG_Gene ecj:JW4182 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4182 OMA RTSMHSH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RTSMHSH PSORT swissprot:Y4223_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:Y4223_ECOLI PSORT-B swissprot:Y4223_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:Y4223_ECOLI PSORT2 swissprot:Y4223_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:Y4223_ECOLI Phobius swissprot:Y4223_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:Y4223_ECOLI ProteinModelPortal P08339 http://www.proteinmodelportal.org/query/uniprot/P08339 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3525538 http://www.ncbi.nlm.nih.gov/pubmed/3525538 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 STRING 316407.85676974 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85676974&targetmode=cogs UniProtKB Y4223_ECOLI http://www.uniprot.org/uniprot/Y4223_ECOLI UniProtKB-AC P08339 http://www.uniprot.org/uniprot/P08339 charge swissprot:Y4223_ECOLI http://rest.g-language.org/emboss/charge/swissprot:Y4223_ECOLI epestfind swissprot:Y4223_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:Y4223_ECOLI garnier swissprot:Y4223_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:Y4223_ECOLI helixturnhelix swissprot:Y4223_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:Y4223_ECOLI hmoment swissprot:Y4223_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:Y4223_ECOLI iep swissprot:Y4223_ECOLI http://rest.g-language.org/emboss/iep/swissprot:Y4223_ECOLI inforesidue swissprot:Y4223_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:Y4223_ECOLI octanol swissprot:Y4223_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:Y4223_ECOLI pepcoil swissprot:Y4223_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:Y4223_ECOLI pepdigest swissprot:Y4223_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:Y4223_ECOLI pepinfo swissprot:Y4223_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:Y4223_ECOLI pepnet swissprot:Y4223_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:Y4223_ECOLI pepstats swissprot:Y4223_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:Y4223_ECOLI pepwheel swissprot:Y4223_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:Y4223_ECOLI pepwindow swissprot:Y4223_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:Y4223_ECOLI sigcleave swissprot:Y4223_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:Y4223_ECOLI ## Database ID URL or Descriptions # BioGrid 4261487 66 # EcoGene EG13989 ydjM # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0009432 SOS response; IEP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006950 response to stress # InterPro IPR007404 YdjM-like # InterPro IPR016956 YdjM # Organism YDJM_ECOLI Escherichia coli (strain K12) # PATRIC 32118763 VBIEscCol129921_1799 # PIR H64931 H64931 # PIRSF PIRSF030780 Md_memb_hyd_prd # Pfam PF04307 YdjM # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDJM_ECOLI Inner membrane protein YdjM # RefSeq NP_416242 NC_000913.3 # RefSeq WP_001297653 NZ_LN832404.1 # SIMILARITY To B.subtilis YvsG. {ECO 0000305}. # SUBCELLULAR LOCATION YDJM_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG COG1988 LUCA # eggNOG ENOG4107K5X Bacteria BLAST swissprot:YDJM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDJM_ECOLI BioCyc ECOL316407:JW5281-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5281-MONOMER BioCyc EcoCyc:G6933-MONOMER http://biocyc.org/getid?id=EcoCyc:G6933-MONOMER COG COG1988 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1988 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3745 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3745 EcoGene EG13989 http://www.ecogene.org/geneInfo.php?eg_id=EG13989 EnsemblBacteria AAC74798 http://www.ensemblgenomes.org/id/AAC74798 EnsemblBacteria AAC74798 http://www.ensemblgenomes.org/id/AAC74798 EnsemblBacteria BAE76511 http://www.ensemblgenomes.org/id/BAE76511 EnsemblBacteria BAE76511 http://www.ensemblgenomes.org/id/BAE76511 EnsemblBacteria BAE76511 http://www.ensemblgenomes.org/id/BAE76511 EnsemblBacteria b1728 http://www.ensemblgenomes.org/id/b1728 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0009432 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009432 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 945644 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945644 HOGENOM HOG000271292 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000271292&db=HOGENOM6 InParanoid P64481 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P64481 InterPro IPR007404 http://www.ebi.ac.uk/interpro/entry/IPR007404 InterPro IPR016956 http://www.ebi.ac.uk/interpro/entry/IPR016956 KEGG_Gene ecj:JW5281 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5281 KEGG_Gene eco:b1728 http://www.genome.jp/dbget-bin/www_bget?eco:b1728 KEGG_Orthology KO:K07038 http://www.genome.jp/dbget-bin/www_bget?KO:K07038 PSORT swissprot:YDJM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDJM_ECOLI PSORT-B swissprot:YDJM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDJM_ECOLI PSORT2 swissprot:YDJM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDJM_ECOLI Pfam PF04307 http://pfam.xfam.org/family/PF04307 Phobius swissprot:YDJM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDJM_ECOLI PhylomeDB P64481 http://phylomedb.org/?seqid=P64481 ProteinModelPortal P64481 http://www.proteinmodelportal.org/query/uniprot/P64481 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416242 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416242 RefSeq WP_001297653 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001297653 STRING 511145.b1728 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1728&targetmode=cogs STRING COG1988 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1988&targetmode=cogs UniProtKB YDJM_ECOLI http://www.uniprot.org/uniprot/YDJM_ECOLI UniProtKB-AC P64481 http://www.uniprot.org/uniprot/P64481 charge swissprot:YDJM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDJM_ECOLI eggNOG COG1988 http://eggnogapi.embl.de/nog_data/html/tree/COG1988 eggNOG ENOG4107K5X http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107K5X epestfind swissprot:YDJM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDJM_ECOLI garnier swissprot:YDJM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDJM_ECOLI helixturnhelix swissprot:YDJM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDJM_ECOLI hmoment swissprot:YDJM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDJM_ECOLI iep swissprot:YDJM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDJM_ECOLI inforesidue swissprot:YDJM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDJM_ECOLI octanol swissprot:YDJM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDJM_ECOLI pepcoil swissprot:YDJM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDJM_ECOLI pepdigest swissprot:YDJM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDJM_ECOLI pepinfo swissprot:YDJM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDJM_ECOLI pepnet swissprot:YDJM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDJM_ECOLI pepstats swissprot:YDJM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDJM_ECOLI pepwheel swissprot:YDJM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDJM_ECOLI pepwindow swissprot:YDJM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDJM_ECOLI sigcleave swissprot:YDJM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDJM_ECOLI ## Database ID URL or Descriptions # BioGrid 4261773 9 # EcoGene EG14098 yfbN # IntAct P76484 7 # Organism YFBN_ECOLI Escherichia coli (strain K12) # PATRIC 32119913 VBIEscCol129921_2366 # PIR G64998 G64998 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFBN_ECOLI Uncharacterized protein YfbN # RefSeq NP_416776 NC_000913.3 # RefSeq WP_000455114 NZ_LN832404.1 # eggNOG ENOG4105ZD8 Bacteria # eggNOG ENOG41125P6 LUCA BLAST swissprot:YFBN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFBN_ECOLI BioCyc ECOL316407:JW2268-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2268-MONOMER BioCyc EcoCyc:G7180-MONOMER http://biocyc.org/getid?id=EcoCyc:G7180-MONOMER DIP DIP-11967N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11967N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3851 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3851 EcoGene EG14098 http://www.ecogene.org/geneInfo.php?eg_id=EG14098 EnsemblBacteria AAC75333 http://www.ensemblgenomes.org/id/AAC75333 EnsemblBacteria AAC75333 http://www.ensemblgenomes.org/id/AAC75333 EnsemblBacteria BAE76681 http://www.ensemblgenomes.org/id/BAE76681 EnsemblBacteria BAE76681 http://www.ensemblgenomes.org/id/BAE76681 EnsemblBacteria BAE76681 http://www.ensemblgenomes.org/id/BAE76681 EnsemblBacteria b2273 http://www.ensemblgenomes.org/id/b2273 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946748 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946748 HOGENOM HOG000009754 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009754&db=HOGENOM6 IntAct P76484 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76484* KEGG_Gene ecj:JW2268 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2268 KEGG_Gene eco:b2273 http://www.genome.jp/dbget-bin/www_bget?eco:b2273 OMA LAMRINQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LAMRINQ PSORT swissprot:YFBN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFBN_ECOLI PSORT-B swissprot:YFBN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFBN_ECOLI PSORT2 swissprot:YFBN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFBN_ECOLI Phobius swissprot:YFBN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFBN_ECOLI ProteinModelPortal P76484 http://www.proteinmodelportal.org/query/uniprot/P76484 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416776 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416776 RefSeq WP_000455114 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000455114 SMR P76484 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76484 STRING 511145.b2273 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2273&targetmode=cogs UniProtKB YFBN_ECOLI http://www.uniprot.org/uniprot/YFBN_ECOLI UniProtKB-AC P76484 http://www.uniprot.org/uniprot/P76484 charge swissprot:YFBN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFBN_ECOLI eggNOG ENOG4105ZD8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ZD8 eggNOG ENOG41125P6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41125P6 epestfind swissprot:YFBN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFBN_ECOLI garnier swissprot:YFBN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFBN_ECOLI helixturnhelix swissprot:YFBN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFBN_ECOLI hmoment swissprot:YFBN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFBN_ECOLI iep swissprot:YFBN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFBN_ECOLI inforesidue swissprot:YFBN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFBN_ECOLI octanol swissprot:YFBN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFBN_ECOLI pepcoil swissprot:YFBN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFBN_ECOLI pepdigest swissprot:YFBN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFBN_ECOLI pepinfo swissprot:YFBN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFBN_ECOLI pepnet swissprot:YFBN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFBN_ECOLI pepstats swissprot:YFBN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFBN_ECOLI pepwheel swissprot:YFBN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFBN_ECOLI pepwindow swissprot:YFBN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFBN_ECOLI sigcleave swissprot:YFBN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFBN_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES YRFG_ECOLI Kinetic parameters KM=0.010 mM for IMP (with manganese ions as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; KM=0.012 mM for GMP (with manganese ions as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; KM=0.062 mM for GMP (with magnesium ions as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; KM=0.22 mM for IMP (with magnesium ions as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; pH dependence Optimum pH is between 6 and 7.5. {ECO 0000269|PubMed 16990279}; # BioGrid 4260978 19 # CATALYTIC ACTIVITY YRFG_ECOLI A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate. # COFACTOR YRFG_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 16990279}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 16990279}; Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000269|PubMed 16990279}; Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 16990279}; Note=Magnesium. Can also use other divalent metal cations as manganese, cobalt or zinc. {ECO 0000269|PubMed 16990279}; # EcoGene EG12928 yrfG # FUNCTION YRFG_ECOLI Catalyzes the dephosphorylation of different purine nucleotides (GMP and IMP). Also hydrolyzes flavin mononucleotide (FMN). {ECO 0000269|PubMed 16990279}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0000287 magnesium ion binding; IDA:UniProtKB. # GO_function GO:0008477 purine nucleosidase activity; IDA:EcoliWiki. # GO_function GO:0030145 manganese ion binding; IDA:UniProtKB. # GO_function GO:0050483 IMP 5'-nucleotidase activity; IDA:EcoCyc. # GO_function GO:0050484 GMP 5'-nucleotidase activity; IDA:EcoCyc. # GO_process GO:0016311 dephosphorylation; IDA:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.1000 -; 1. # InterPro IPR006439 HAD-SF_hydro_IA # InterPro IPR023214 HAD-like_dom # Organism YRFG_ECOLI Escherichia coli (strain K12) # PATRIC 32122232 VBIEscCol129921_3493 # PIR B65135 B65135 # PRINTS PR00413 HADHALOGNASE # Pfam PF13419 HAD_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YRFG_ECOLI GMP/IMP nucleotidase YrfG # RefSeq NP_417858 NC_000913.3 # RefSeq WP_001295168 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA58196.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the HAD-like hydrolase superfamily. {ECO 0000305}. # SUPFAM SSF56784 SSF56784 # TIGRFAMs TIGR01509 HAD-SF-IA-v3 # eggNOG COG1011 LUCA # eggNOG ENOG4107Y3D Bacteria BLAST swissprot:YRFG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YRFG_ECOLI BioCyc ECOL316407:JW5865-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5865-MONOMER BioCyc EcoCyc:G7742-MONOMER http://biocyc.org/getid?id=EcoCyc:G7742-MONOMER BioCyc MetaCyc:G7742-MONOMER http://biocyc.org/getid?id=MetaCyc:G7742-MONOMER COG COG1011 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1011 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M605449200 http://dx.doi.org/10.1074/jbc.M605449200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.3.5 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.5 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 3.1.3.5 http://enzyme.expasy.org/EC/3.1.3.5 EchoBASE EB2764 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2764 EcoGene EG12928 http://www.ecogene.org/geneInfo.php?eg_id=EG12928 EnsemblBacteria AAC76424 http://www.ensemblgenomes.org/id/AAC76424 EnsemblBacteria AAC76424 http://www.ensemblgenomes.org/id/AAC76424 EnsemblBacteria BAE77892 http://www.ensemblgenomes.org/id/BAE77892 EnsemblBacteria BAE77892 http://www.ensemblgenomes.org/id/BAE77892 EnsemblBacteria BAE77892 http://www.ensemblgenomes.org/id/BAE77892 EnsemblBacteria b3399 http://www.ensemblgenomes.org/id/b3399 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0008477 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008477 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_function GO:0050483 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050483 GO_function GO:0050484 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050484 GO_process GO:0016311 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016311 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.1000 http://www.cathdb.info/version/latest/superfamily/3.40.50.1000 GeneID 947904 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947904 HOGENOM HOG000271571 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000271571&db=HOGENOM6 InParanoid P64636 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P64636 IntEnz 3.1.3.5 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.5 InterPro IPR006439 http://www.ebi.ac.uk/interpro/entry/IPR006439 InterPro IPR023214 http://www.ebi.ac.uk/interpro/entry/IPR023214 KEGG_Gene ecj:JW5865 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5865 KEGG_Gene eco:b3399 http://www.genome.jp/dbget-bin/www_bget?eco:b3399 KEGG_Orthology KO:K07025 http://www.genome.jp/dbget-bin/www_bget?KO:K07025 OMA NPDSQKP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NPDSQKP PRINTS PR00413 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00413 PSORT swissprot:YRFG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YRFG_ECOLI PSORT-B swissprot:YRFG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YRFG_ECOLI PSORT2 swissprot:YRFG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YRFG_ECOLI Pfam PF13419 http://pfam.xfam.org/family/PF13419 Phobius swissprot:YRFG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YRFG_ECOLI PhylomeDB P64636 http://phylomedb.org/?seqid=P64636 ProteinModelPortal P64636 http://www.proteinmodelportal.org/query/uniprot/P64636 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16990279 http://www.ncbi.nlm.nih.gov/pubmed/16990279 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417858 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417858 RefSeq WP_001295168 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295168 SMR P64636 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P64636 STRING 511145.b3399 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3399&targetmode=cogs STRING COG1011 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1011&targetmode=cogs SUPFAM SSF56784 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784 TIGRFAMs TIGR01509 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01509 UniProtKB YRFG_ECOLI http://www.uniprot.org/uniprot/YRFG_ECOLI UniProtKB-AC P64636 http://www.uniprot.org/uniprot/P64636 charge swissprot:YRFG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YRFG_ECOLI eggNOG COG1011 http://eggnogapi.embl.de/nog_data/html/tree/COG1011 eggNOG ENOG4107Y3D http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107Y3D epestfind swissprot:YRFG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YRFG_ECOLI garnier swissprot:YRFG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YRFG_ECOLI helixturnhelix swissprot:YRFG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YRFG_ECOLI hmoment swissprot:YRFG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YRFG_ECOLI iep swissprot:YRFG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YRFG_ECOLI inforesidue swissprot:YRFG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YRFG_ECOLI octanol swissprot:YRFG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YRFG_ECOLI pepcoil swissprot:YRFG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YRFG_ECOLI pepdigest swissprot:YRFG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YRFG_ECOLI pepinfo swissprot:YRFG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YRFG_ECOLI pepnet swissprot:YRFG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YRFG_ECOLI pepstats swissprot:YRFG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YRFG_ECOLI pepwheel swissprot:YRFG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YRFG_ECOLI pepwindow swissprot:YRFG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YRFG_ECOLI sigcleave swissprot:YRFG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YRFG_ECOLI ## Database ID URL or Descriptions # BioGrid 4262372 7 # EcoGene EG11805 hybG # FUNCTION HYBG_ECOLI May have a specific role in the maturation of the large subunits of HYD1 and HYD2. # GO_function GO:0005506 iron ion binding; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:1902670 carbon dioxide binding; IDA:EcoCyc. # GO_process GO:0051604 protein maturation; IDA:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0051604 protein maturation # INTERACTION HYBG_ECOLI P24192 hypD; NbExp=7; IntAct=EBI-562426, EBI-552711; # IntAct P0AAM7 10 # InterPro IPR001109 Hydrogenase_HupF/HypC # InterPro IPR019812 Hydgase_assmbl_chp_CS # Organism HYBG_ECOLI Escherichia coli (strain K12) # PATRIC 32121396 VBIEscCol129921_3085 # PIR G55516 G55516 # PRINTS PR00445 HUPFHYPC # PROSITE PS01097 HUPF_HYPC # Pfam PF01455 HupF_HypC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HYBG_ECOLI Hydrogenase-2 operon protein HybG # RefSeq NP_417464 NC_000913.3 # RefSeq WP_000334896 NZ_LN832404.1 # SIMILARITY Belongs to the HupF/HypC family. {ECO 0000305}. # TIGRFAMs TIGR00074 hypC_hupF # eggNOG COG0298 LUCA # eggNOG ENOG41082MF Bacteria BLAST swissprot:HYBG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HYBG_ECOLI BioCyc ECOL316407:JW2958-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2958-MONOMER BioCyc EcoCyc:EG11805-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11805-MONOMER COG COG0298 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0298 DIP DIP-36429N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36429N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U09177 http://www.ebi.ac.uk/ena/data/view/U09177 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB1753 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1753 EcoGene EG11805 http://www.ecogene.org/geneInfo.php?eg_id=EG11805 EnsemblBacteria AAC76026 http://www.ensemblgenomes.org/id/AAC76026 EnsemblBacteria AAC76026 http://www.ensemblgenomes.org/id/AAC76026 EnsemblBacteria BAE77051 http://www.ensemblgenomes.org/id/BAE77051 EnsemblBacteria BAE77051 http://www.ensemblgenomes.org/id/BAE77051 EnsemblBacteria BAE77051 http://www.ensemblgenomes.org/id/BAE77051 EnsemblBacteria b2990 http://www.ensemblgenomes.org/id/b2990 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:1902670 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902670 GO_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 GeneID 948020 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948020 HOGENOM HOG000278755 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278755&db=HOGENOM6 InParanoid P0AAM7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAM7 IntAct P0AAM7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAM7* InterPro IPR001109 http://www.ebi.ac.uk/interpro/entry/IPR001109 InterPro IPR019812 http://www.ebi.ac.uk/interpro/entry/IPR019812 KEGG_Gene ecj:JW2958 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2958 KEGG_Gene eco:b2990 http://www.genome.jp/dbget-bin/www_bget?eco:b2990 KEGG_Orthology KO:K04653 http://www.genome.jp/dbget-bin/www_bget?KO:K04653 OMA FAMNRIN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FAMNRIN PRINTS PR00445 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00445 PROSITE PS01097 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01097 PSORT swissprot:HYBG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HYBG_ECOLI PSORT-B swissprot:HYBG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HYBG_ECOLI PSORT2 swissprot:HYBG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HYBG_ECOLI Pfam PF01455 http://pfam.xfam.org/family/PF01455 Phobius swissprot:HYBG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HYBG_ECOLI PhylomeDB P0AAM7 http://phylomedb.org/?seqid=P0AAM7 ProteinModelPortal P0AAM7 http://www.proteinmodelportal.org/query/uniprot/P0AAM7 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8021226 http://www.ncbi.nlm.nih.gov/pubmed/8021226 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417464 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417464 RefSeq WP_000334896 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000334896 SMR P0AAM7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAM7 STRING 511145.b2990 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2990&targetmode=cogs STRING COG0298 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0298&targetmode=cogs TIGRFAMs TIGR00074 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00074 UniProtKB HYBG_ECOLI http://www.uniprot.org/uniprot/HYBG_ECOLI UniProtKB-AC P0AAM7 http://www.uniprot.org/uniprot/P0AAM7 charge swissprot:HYBG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HYBG_ECOLI eggNOG COG0298 http://eggnogapi.embl.de/nog_data/html/tree/COG0298 eggNOG ENOG41082MF http://eggnogapi.embl.de/nog_data/html/tree/ENOG41082MF epestfind swissprot:HYBG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HYBG_ECOLI garnier swissprot:HYBG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HYBG_ECOLI helixturnhelix swissprot:HYBG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HYBG_ECOLI hmoment swissprot:HYBG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HYBG_ECOLI iep swissprot:HYBG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HYBG_ECOLI inforesidue swissprot:HYBG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HYBG_ECOLI octanol swissprot:HYBG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HYBG_ECOLI pepcoil swissprot:HYBG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HYBG_ECOLI pepdigest swissprot:HYBG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HYBG_ECOLI pepinfo swissprot:HYBG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HYBG_ECOLI pepnet swissprot:HYBG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HYBG_ECOLI pepstats swissprot:HYBG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HYBG_ECOLI pepwheel swissprot:HYBG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HYBG_ECOLI pepwindow swissprot:HYBG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HYBG_ECOLI sigcleave swissprot:HYBG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HYBG_ECOLI ## Database ID URL or Descriptions # BioGrid 4263446 16 # EcoGene EG12719 ygjH # GO_component GO:0017101 aminoacyl-tRNA synthetase multienzyme complex; IBA:GO_Central. # GO_component GO:0017102 methionyl glutamyl tRNA synthetase complex; IBA:GO_Central. # GO_function GO:0000049 tRNA binding; IBA:GO_Central. # GO_process GO:0006418 tRNA aminoacylation for protein translation; IBA:GO_Central. # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003723 RNA binding # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0006520 cellular amino acid metabolic process # IntAct P42589 2 # InterPro IPR002547 tRNA-bd_dom # InterPro IPR012340 NA-bd_OB-fold # Organism YGJH_ECOLI Escherichia coli (strain K12) # PATRIC 32121564 VBIEscCol129921_3168 # PDB 3ERS X-ray; 1.87 A; X=1-110 # PIR G65095 G65095 # PROSITE PS50886 TRBD # Pfam PF01588 tRNA_bind # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGJH_ECOLI tRNA-binding protein YgjH # RefSeq NP_417545 NC_000913.3 # RefSeq WP_000450594 NZ_LN832404.1 # SIMILARITY Contains 1 tRNA-binding domain. {ECO:0000255|PROSITE- ProRule PRU00209}. # SUBUNIT YGJH_ECOLI Homodimer. # SUPFAM SSF50249 SSF50249 # eggNOG COG0073 LUCA # eggNOG ENOG4108Y51 Bacteria BLAST swissprot:YGJH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGJH_ECOLI BioCyc ECOL316407:JW3045-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3045-MONOMER BioCyc EcoCyc:G7597-MONOMER http://biocyc.org/getid?id=EcoCyc:G7597-MONOMER COG COG0073 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0073 DIP DIP-12234N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12234N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/emboj/19.23.6287 http://dx.doi.org/10.1093/emboj/19.23.6287 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2578 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2578 EcoGene EG12719 http://www.ecogene.org/geneInfo.php?eg_id=EG12719 EnsemblBacteria AAC76109 http://www.ensemblgenomes.org/id/AAC76109 EnsemblBacteria AAC76109 http://www.ensemblgenomes.org/id/AAC76109 EnsemblBacteria BAE77124 http://www.ensemblgenomes.org/id/BAE77124 EnsemblBacteria BAE77124 http://www.ensemblgenomes.org/id/BAE77124 EnsemblBacteria BAE77124 http://www.ensemblgenomes.org/id/BAE77124 EnsemblBacteria b3074 http://www.ensemblgenomes.org/id/b3074 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0017101 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017101 GO_component GO:0017102 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017102 GO_function GO:0000049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000049 GO_process GO:0006418 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006418 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GeneID 946251 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946251 HOGENOM HOG000269896 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000269896&db=HOGENOM6 InParanoid P42589 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P42589 IntAct P42589 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P42589* InterPro IPR002547 http://www.ebi.ac.uk/interpro/entry/IPR002547 InterPro IPR012340 http://www.ebi.ac.uk/interpro/entry/IPR012340 KEGG_Gene ecj:JW3045 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3045 KEGG_Gene eco:b3074 http://www.genome.jp/dbget-bin/www_bget?eco:b3074 KEGG_Orthology KO:K06878 http://www.genome.jp/dbget-bin/www_bget?KO:K06878 MINT MINT-1283890 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1283890 OMA AGLAEYY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AGLAEYY PDB 3ERS http://www.ebi.ac.uk/pdbe-srv/view/entry/3ERS PDBsum 3ERS http://www.ebi.ac.uk/pdbsum/3ERS PROSITE PS50886 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50886 PSORT swissprot:YGJH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGJH_ECOLI PSORT-B swissprot:YGJH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGJH_ECOLI PSORT2 swissprot:YGJH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGJH_ECOLI Pfam PF01588 http://pfam.xfam.org/family/PF01588 Phobius swissprot:YGJH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGJH_ECOLI PhylomeDB P42589 http://phylomedb.org/?seqid=P42589 ProteinModelPortal P42589 http://www.proteinmodelportal.org/query/uniprot/P42589 PubMed 11101501 http://www.ncbi.nlm.nih.gov/pubmed/11101501 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417545 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417545 RefSeq WP_000450594 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000450594 SMR P42589 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P42589 STRING 511145.b3074 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3074&targetmode=cogs STRING COG0073 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0073&targetmode=cogs SUPFAM SSF50249 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50249 UniProtKB YGJH_ECOLI http://www.uniprot.org/uniprot/YGJH_ECOLI UniProtKB-AC P42589 http://www.uniprot.org/uniprot/P42589 charge swissprot:YGJH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGJH_ECOLI eggNOG COG0073 http://eggnogapi.embl.de/nog_data/html/tree/COG0073 eggNOG ENOG4108Y51 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Y51 epestfind swissprot:YGJH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGJH_ECOLI garnier swissprot:YGJH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGJH_ECOLI helixturnhelix swissprot:YGJH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGJH_ECOLI hmoment swissprot:YGJH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGJH_ECOLI iep swissprot:YGJH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGJH_ECOLI inforesidue swissprot:YGJH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGJH_ECOLI octanol swissprot:YGJH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGJH_ECOLI pepcoil swissprot:YGJH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGJH_ECOLI pepdigest swissprot:YGJH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGJH_ECOLI pepinfo swissprot:YGJH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGJH_ECOLI pepnet swissprot:YGJH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGJH_ECOLI pepstats swissprot:YGJH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGJH_ECOLI pepwheel swissprot:YGJH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGJH_ECOLI pepwindow swissprot:YGJH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGJH_ECOLI sigcleave swissprot:YGJH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGJH_ECOLI ## Database ID URL or Descriptions # BioGrid 4260383 4 # EcoGene EG11347 fliF # FUNCTION FLIF_ECOLI The M ring may be actively involved in energy transduction. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0009431 bacterial-type flagellum basal body, MS ring; IEA:InterPro. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0003774 motor activity; IEA:InterPro. # GO_process GO:0071973 bacterial-type flagellum-dependent cell motility; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0048870 cell motility # INTERACTION FLIF_ECOLI P0ABZ1 fliG; NbExp=4; IntAct=EBI-1126492, EBI-1126524; # IntAct P25798 4 # InterPro IPR000067 FlgMring_FliF # InterPro IPR006182 YscJ_FliF # InterPro IPR013556 Flag_M-ring_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko02040 Flagellar assembly # Organism FLIF_ECOLI Escherichia coli (strain K12) # PATRIC 32119205 VBIEscCol129921_2017 # PIR G64957 G64957 # PIRSF PIRSF004862 FliF # PRINTS PR01009 FLGMRINGFLIF # Pfam PF01514 YscJ_FliF # Pfam PF08345 YscJ_FliF_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FLIF_ECOLI Flagellar M-ring protein # RefSeq NP_416448 NC_000913.3 # RefSeq WP_000994427 NZ_LN832404.1 # SIMILARITY Belongs to the FliF family. {ECO 0000305}. # SUBCELLULAR LOCATION FLIF_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. Bacterial flagellum basal body {ECO 0000269|PubMed 15919996}. # SUBUNIT FLIF_ECOLI The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The M ring is integral to the inner membrane of the cell and may be connected to the flagellar rod via the S ring. The S (supramembrane ring) lies just distal to the M ring. The L and P rings lie in the outer membrane and the periplasmic space, respectively. # TIGRFAMs TIGR00206 fliF # eggNOG COG1766 LUCA # eggNOG ENOG4105C1F Bacteria BLAST swissprot:FLIF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLIF_ECOLI BioCyc ECOL316407:JW1922-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1922-MONOMER BioCyc EcoCyc:FLIF-FLAGELLAR-MS-RING http://biocyc.org/getid?id=EcoCyc:FLIF-FLAGELLAR-MS-RING COG COG1766 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1766 DIP DIP-401N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-401N DOI 10.1016/0378-1119(93)90232-R http://dx.doi.org/10.1016/0378-1119(93)90232-R DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D89826 http://www.ebi.ac.uk/ena/data/view/D89826 EMBL L13243 http://www.ebi.ac.uk/ena/data/view/L13243 EMBL M84992 http://www.ebi.ac.uk/ena/data/view/M84992 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1323 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1323 EcoGene EG11347 http://www.ecogene.org/geneInfo.php?eg_id=EG11347 EnsemblBacteria AAC75005 http://www.ensemblgenomes.org/id/AAC75005 EnsemblBacteria AAC75005 http://www.ensemblgenomes.org/id/AAC75005 EnsemblBacteria BAA15763 http://www.ensemblgenomes.org/id/BAA15763 EnsemblBacteria BAA15763 http://www.ensemblgenomes.org/id/BAA15763 EnsemblBacteria BAA15763 http://www.ensemblgenomes.org/id/BAA15763 EnsemblBacteria b1938 http://www.ensemblgenomes.org/id/b1938 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0009431 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009431 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0003774 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003774 GO_process GO:0071973 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071973 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 GeneID 946448 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946448 HOGENOM HOG000265848 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000265848&db=HOGENOM6 InParanoid P25798 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P25798 IntAct P25798 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P25798* InterPro IPR000067 http://www.ebi.ac.uk/interpro/entry/IPR000067 InterPro IPR006182 http://www.ebi.ac.uk/interpro/entry/IPR006182 InterPro IPR013556 http://www.ebi.ac.uk/interpro/entry/IPR013556 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW1922 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1922 KEGG_Gene eco:b1938 http://www.genome.jp/dbget-bin/www_bget?eco:b1938 KEGG_Orthology KO:K02409 http://www.genome.jp/dbget-bin/www_bget?KO:K02409 KEGG_Pathway ko02040 http://www.genome.jp/kegg-bin/show_pathway?ko02040 OMA NFQRGLE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NFQRGLE PRINTS PR01009 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01009 PSORT swissprot:FLIF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLIF_ECOLI PSORT-B swissprot:FLIF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLIF_ECOLI PSORT2 swissprot:FLIF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLIF_ECOLI Pfam PF01514 http://pfam.xfam.org/family/PF01514 Pfam PF08345 http://pfam.xfam.org/family/PF08345 Phobius swissprot:FLIF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLIF_ECOLI PhylomeDB P25798 http://phylomedb.org/?seqid=P25798 ProteinModelPortal P25798 http://www.proteinmodelportal.org/query/uniprot/P25798 PubMed 1551848 http://www.ncbi.nlm.nih.gov/pubmed/1551848 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8224881 http://www.ncbi.nlm.nih.gov/pubmed/8224881 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416448 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416448 RefSeq WP_000994427 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000994427 SMR P25798 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P25798 STRING 511145.b1938 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1938&targetmode=cogs STRING COG1766 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1766&targetmode=cogs TIGRFAMs TIGR00206 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00206 UniProtKB FLIF_ECOLI http://www.uniprot.org/uniprot/FLIF_ECOLI UniProtKB-AC P25798 http://www.uniprot.org/uniprot/P25798 charge swissprot:FLIF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLIF_ECOLI eggNOG COG1766 http://eggnogapi.embl.de/nog_data/html/tree/COG1766 eggNOG ENOG4105C1F http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C1F epestfind swissprot:FLIF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLIF_ECOLI garnier swissprot:FLIF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLIF_ECOLI helixturnhelix swissprot:FLIF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLIF_ECOLI hmoment swissprot:FLIF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLIF_ECOLI iep swissprot:FLIF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLIF_ECOLI inforesidue swissprot:FLIF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLIF_ECOLI octanol swissprot:FLIF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLIF_ECOLI pepcoil swissprot:FLIF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLIF_ECOLI pepdigest swissprot:FLIF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLIF_ECOLI pepinfo swissprot:FLIF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLIF_ECOLI pepnet swissprot:FLIF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLIF_ECOLI pepstats swissprot:FLIF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLIF_ECOLI pepwheel swissprot:FLIF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLIF_ECOLI pepwindow swissprot:FLIF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLIF_ECOLI sigcleave swissprot:FLIF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLIF_ECOLI ## Database ID URL or Descriptions # BioGrid 4261099 128 # EcoGene EG11853 yiiD # GO_component GO:0031248 protein acetyltransferase complex; IBA:GO_Central. # GO_function GO:0004596 peptide alpha-N-acetyltransferase activity; IBA:GO_Central. # GO_process GO:0006474 N-terminal protein amino acid acetylation; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0006464 cellular protein modification process # Gene3D 3.10.129.10 -; 1. # Gene3D 3.40.630.30 -; 1. # IntAct P0ADQ2 10 # InterPro IPR000182 GNAT_dom # InterPro IPR012660 YiiD_C # InterPro IPR016181 Acyl_CoA_acyltransferase # InterPro IPR029069 HotDog_dom # Organism YIID_ECOLI Escherichia coli (strain K12) # PATRIC 32123279 VBIEscCol129921_4000 # PIR S40832 S40832 # PROSITE PS51186 GNAT # Pfam PF00583 Acetyltransf_1 # Pfam PF09500 YiiD_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIID_ECOLI Uncharacterized protein YiiD # RefSeq NP_418324 NC_000913.3 # SIMILARITY Contains 1 N-acetyltransferase domain. {ECO:0000255|PROSITE-ProRule PRU00532}. # SUPFAM SSF54637 SSF54637 # SUPFAM SSF55729 SSF55729 # TIGRFAMs TIGR02447 yiiD_Cterm # eggNOG ENOG4105SUU Bacteria # eggNOG ENOG41126DB LUCA BLAST swissprot:YIID_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIID_ECOLI BioCyc ECOL316407:JW3859-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3859-MONOMER BioCyc EcoCyc:EG11853-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11853-MONOMER DIP DIP-48207N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48207N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1799 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1799 EcoGene EG11853 http://www.ecogene.org/geneInfo.php?eg_id=EG11853 EnsemblBacteria AAD13450 http://www.ensemblgenomes.org/id/AAD13450 EnsemblBacteria AAD13450 http://www.ensemblgenomes.org/id/AAD13450 EnsemblBacteria BAE77421 http://www.ensemblgenomes.org/id/BAE77421 EnsemblBacteria BAE77421 http://www.ensemblgenomes.org/id/BAE77421 EnsemblBacteria BAE77421 http://www.ensemblgenomes.org/id/BAE77421 EnsemblBacteria b3888 http://www.ensemblgenomes.org/id/b3888 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0031248 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031248 GO_function GO:0004596 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004596 GO_process GO:0006474 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006474 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 Gene3D 3.10.129.10 http://www.cathdb.info/version/latest/superfamily/3.10.129.10 Gene3D 3.40.630.30 http://www.cathdb.info/version/latest/superfamily/3.40.630.30 GeneID 948387 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948387 HOGENOM HOG000270144 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000270144&db=HOGENOM6 IntAct P0ADQ2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADQ2* InterPro IPR000182 http://www.ebi.ac.uk/interpro/entry/IPR000182 InterPro IPR012660 http://www.ebi.ac.uk/interpro/entry/IPR012660 InterPro IPR016181 http://www.ebi.ac.uk/interpro/entry/IPR016181 InterPro IPR029069 http://www.ebi.ac.uk/interpro/entry/IPR029069 KEGG_Gene ecj:JW3859 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3859 KEGG_Gene eco:b3888 http://www.genome.jp/dbget-bin/www_bget?eco:b3888 MINT MINT-1256345 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1256345 OMA NDGQIRY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NDGQIRY PROSITE PS51186 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51186 PSORT swissprot:YIID_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIID_ECOLI PSORT-B swissprot:YIID_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIID_ECOLI PSORT2 swissprot:YIID_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIID_ECOLI Pfam PF00583 http://pfam.xfam.org/family/PF00583 Pfam PF09500 http://pfam.xfam.org/family/PF09500 Phobius swissprot:YIID_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIID_ECOLI ProteinModelPortal P0ADQ2 http://www.proteinmodelportal.org/query/uniprot/P0ADQ2 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418324 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418324 SMR P0ADQ2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADQ2 STRING 511145.b3888 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3888&targetmode=cogs SUPFAM SSF54637 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54637 SUPFAM SSF55729 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55729 TIGRFAMs TIGR02447 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02447 UniProtKB YIID_ECOLI http://www.uniprot.org/uniprot/YIID_ECOLI UniProtKB-AC P0ADQ2 http://www.uniprot.org/uniprot/P0ADQ2 charge swissprot:YIID_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIID_ECOLI eggNOG ENOG4105SUU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105SUU eggNOG ENOG41126DB http://eggnogapi.embl.de/nog_data/html/tree/ENOG41126DB epestfind swissprot:YIID_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIID_ECOLI garnier swissprot:YIID_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIID_ECOLI helixturnhelix swissprot:YIID_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIID_ECOLI hmoment swissprot:YIID_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIID_ECOLI iep swissprot:YIID_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIID_ECOLI inforesidue swissprot:YIID_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIID_ECOLI octanol swissprot:YIID_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIID_ECOLI pepcoil swissprot:YIID_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIID_ECOLI pepdigest swissprot:YIID_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIID_ECOLI pepinfo swissprot:YIID_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIID_ECOLI pepnet swissprot:YIID_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIID_ECOLI pepstats swissprot:YIID_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIID_ECOLI pepwheel swissprot:YIID_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIID_ECOLI pepwindow swissprot:YIID_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIID_ECOLI sigcleave swissprot:YIID_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIID_ECOLI ## Database ID URL or Descriptions # BioGrid 4261203 185 # EcoGene EG11832 yihF # InterPro IPR010352 DUF945 # Organism YIHF_ECOLI Escherichia coli (strain K12) # PATRIC 32123219 VBIEscCol129921_3970 # PIR A65191 A65191 # Pfam PF06097 DUF945 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIHF_ECOLI Uncharacterized protein YihF # RefSeq NP_418298 NC_000913.3 # RefSeq WP_001333507 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB02996.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAE77447.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY To E.coli YdgA and H.influenzae HI_1236. {ECO 0000305}. # eggNOG COG5339 LUCA BLAST swissprot:YIHF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIHF_ECOLI BioCyc ECOL316407:JW5574-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5574-MONOMER BioCyc EcoCyc:EG11832-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11832-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1099/13500872-140-12-3337 http://dx.doi.org/10.1099/13500872-140-12-3337 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X80762 http://www.ebi.ac.uk/ena/data/view/X80762 EchoBASE EB1779 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1779 EcoGene EG11832 http://www.ecogene.org/geneInfo.php?eg_id=EG11832 EnsemblBacteria AAC76859 http://www.ensemblgenomes.org/id/AAC76859 EnsemblBacteria AAC76859 http://www.ensemblgenomes.org/id/AAC76859 EnsemblBacteria BAE77447 http://www.ensemblgenomes.org/id/BAE77447 EnsemblBacteria BAE77447 http://www.ensemblgenomes.org/id/BAE77447 EnsemblBacteria BAE77447 http://www.ensemblgenomes.org/id/BAE77447 EnsemblBacteria b3861 http://www.ensemblgenomes.org/id/b3861 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 948352 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948352 HOGENOM HOG000126606 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126606&db=HOGENOM6 InterPro IPR010352 http://www.ebi.ac.uk/interpro/entry/IPR010352 KEGG_Gene ecj:JW5574 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5574 KEGG_Gene eco:b3861 http://www.genome.jp/dbget-bin/www_bget?eco:b3861 OMA PITMLMR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PITMLMR PSORT swissprot:YIHF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIHF_ECOLI PSORT-B swissprot:YIHF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIHF_ECOLI PSORT2 swissprot:YIHF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIHF_ECOLI Pfam PF06097 http://pfam.xfam.org/family/PF06097 Phobius swissprot:YIHF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIHF_ECOLI ProteinModelPortal P32128 http://www.proteinmodelportal.org/query/uniprot/P32128 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7881552 http://www.ncbi.nlm.nih.gov/pubmed/7881552 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418298 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418298 RefSeq WP_001333507 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001333507 STRING 511145.b3861 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3861&targetmode=cogs UniProtKB YIHF_ECOLI http://www.uniprot.org/uniprot/YIHF_ECOLI UniProtKB-AC P32128 http://www.uniprot.org/uniprot/P32128 charge swissprot:YIHF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIHF_ECOLI eggNOG COG5339 http://eggnogapi.embl.de/nog_data/html/tree/COG5339 epestfind swissprot:YIHF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIHF_ECOLI garnier swissprot:YIHF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIHF_ECOLI helixturnhelix swissprot:YIHF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIHF_ECOLI hmoment swissprot:YIHF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIHF_ECOLI iep swissprot:YIHF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIHF_ECOLI inforesidue swissprot:YIHF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIHF_ECOLI octanol swissprot:YIHF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIHF_ECOLI pepcoil swissprot:YIHF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIHF_ECOLI pepdigest swissprot:YIHF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIHF_ECOLI pepinfo swissprot:YIHF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIHF_ECOLI pepnet swissprot:YIHF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIHF_ECOLI pepstats swissprot:YIHF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIHF_ECOLI pepwheel swissprot:YIHF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIHF_ECOLI pepwindow swissprot:YIHF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIHF_ECOLI sigcleave swissprot:YIHF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIHF_ECOLI ## Database ID URL or Descriptions # AltName 4-methyl-5-beta-hydroxyethylthiazole kinase {ECO:0000255|HAMAP-Rule MF_00228} # BioGrid 4261165 302 # CATALYTIC ACTIVITY THIM_ECOLI ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. {ECO 0000255|HAMAP-Rule MF_00228, ECO 0000269|PubMed 2542220}. # CDD cd01170 THZ_kinase # COFACTOR THIM_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_00228}; # EcoGene EG14069 thiM # FUNCTION THIM_ECOLI Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ). {ECO 0000255|HAMAP- Rule MF_00228, ECO 0000269|PubMed 2542220}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0004417 hydroxyethylthiazole kinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_process GO:0009228 thiamine biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0009229 thiamine diphosphate biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.1190.20 -; 1. # HAMAP MF_00228 Thz_kinase # IntAct P76423 2 # InterPro IPR000417 Hyethyz_kinase # InterPro IPR029056 Ribokinase-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00730 Thiamine metabolism # Organism THIM_ECOLI Escherichia coli (strain K12) # PATHWAY THIM_ECOLI Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4- methylthiazole step 1/1. {ECO 0000255|HAMAP-Rule MF_00228, ECO 0000269|PubMed 2542220}. # PATRIC 32119541 VBIEscCol129921_2181 # PIR G64977 G64977 # PIRSF PIRSF000513 Thz_kinase # PRINTS PR01099 HYETHTZKNASE # Pfam PF02110 HK # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Hydroxyethylthiazole kinase {ECO:0000255|HAMAP-Rule MF_00228} # RefSeq NP_416607 NC_000913.3 # RefSeq WP_001195564 NZ_LN832404.1 # SIMILARITY Belongs to the Thz kinase family. {ECO:0000255|HAMAP- Rule MF_00228}. # SUPFAM SSF53613 SSF53613 # TIGRFAMs TIGR00694 thiM # UniPathway UPA00060 UER00139 # eggNOG COG2145 LUCA # eggNOG ENOG4105C4U Bacteria BLAST swissprot:THIM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:THIM_ECOLI BioCyc ECOL316407:JW2091-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2091-MONOMER BioCyc EcoCyc:THZ-KIN-MONOMER http://biocyc.org/getid?id=EcoCyc:THZ-KIN-MONOMER BioCyc MetaCyc:THZ-KIN-MONOMER http://biocyc.org/getid?id=MetaCyc:THZ-KIN-MONOMER COG COG2145 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2145 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1099/13500872-145-2-495 http://dx.doi.org/10.1099/13500872-145-2-495 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.50 {ECO:0000255|HAMAP-Rule:MF_00228} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.50 {ECO:0000255|HAMAP-Rule:MF_00228} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D88442 http://www.ebi.ac.uk/ena/data/view/D88442 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.50 {ECO:0000255|HAMAP-Rule:MF_00228} http://enzyme.expasy.org/EC/2.7.1.50 {ECO:0000255|HAMAP-Rule:MF_00228} EchoBASE EB3822 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3822 EcoGene EG14069 http://www.ecogene.org/geneInfo.php?eg_id=EG14069 EnsemblBacteria AAC75165 http://www.ensemblgenomes.org/id/AAC75165 EnsemblBacteria AAC75165 http://www.ensemblgenomes.org/id/AAC75165 EnsemblBacteria BAA15972 http://www.ensemblgenomes.org/id/BAA15972 EnsemblBacteria BAA15972 http://www.ensemblgenomes.org/id/BAA15972 EnsemblBacteria BAA15972 http://www.ensemblgenomes.org/id/BAA15972 EnsemblBacteria b2104 http://www.ensemblgenomes.org/id/b2104 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0004417 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004417 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0009228 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009228 GO_process GO:0009229 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009229 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.1190.20 http://www.cathdb.info/version/latest/superfamily/3.40.1190.20 GeneID 945142 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945142 HAMAP MF_00228 http://hamap.expasy.org/unirule/MF_00228 HOGENOM HOG000114352 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000114352&db=HOGENOM6 InParanoid P76423 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76423 IntAct P76423 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76423* IntEnz 2.7.1.50 {ECO:0000255|HAMAP-Rule:MF_00228} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.50 {ECO:0000255|HAMAP-Rule:MF_00228} InterPro IPR000417 http://www.ebi.ac.uk/interpro/entry/IPR000417 InterPro IPR029056 http://www.ebi.ac.uk/interpro/entry/IPR029056 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2091 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2091 KEGG_Gene eco:b2104 http://www.genome.jp/dbget-bin/www_bget?eco:b2104 KEGG_Orthology KO:K00878 http://www.genome.jp/dbget-bin/www_bget?KO:K00878 KEGG_Pathway ko00730 http://www.genome.jp/kegg-bin/show_pathway?ko00730 KEGG_Reaction rn:R04448 http://www.genome.jp/dbget-bin/www_bget?rn:R04448 OMA SPVMAHA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SPVMAHA PRINTS PR01099 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01099 PSORT swissprot:THIM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:THIM_ECOLI PSORT-B swissprot:THIM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:THIM_ECOLI PSORT2 swissprot:THIM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:THIM_ECOLI Pfam PF02110 http://pfam.xfam.org/family/PF02110 Phobius swissprot:THIM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:THIM_ECOLI PhylomeDB P76423 http://phylomedb.org/?seqid=P76423 ProteinModelPortal P76423 http://www.proteinmodelportal.org/query/uniprot/P76423 PubMed 10075431 http://www.ncbi.nlm.nih.gov/pubmed/10075431 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2542220 http://www.ncbi.nlm.nih.gov/pubmed/2542220 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416607 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416607 RefSeq WP_001195564 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001195564 SMR P76423 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76423 STRING 511145.b2104 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2104&targetmode=cogs STRING COG2145 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2145&targetmode=cogs SUPFAM SSF53613 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53613 TIGRFAMs TIGR00694 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00694 UniProtKB THIM_ECOLI http://www.uniprot.org/uniprot/THIM_ECOLI UniProtKB-AC P76423 http://www.uniprot.org/uniprot/P76423 charge swissprot:THIM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:THIM_ECOLI eggNOG COG2145 http://eggnogapi.embl.de/nog_data/html/tree/COG2145 eggNOG ENOG4105C4U http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C4U epestfind swissprot:THIM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:THIM_ECOLI garnier swissprot:THIM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:THIM_ECOLI helixturnhelix swissprot:THIM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:THIM_ECOLI hmoment swissprot:THIM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:THIM_ECOLI iep swissprot:THIM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:THIM_ECOLI inforesidue swissprot:THIM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:THIM_ECOLI octanol swissprot:THIM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:THIM_ECOLI pepcoil swissprot:THIM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:THIM_ECOLI pepdigest swissprot:THIM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:THIM_ECOLI pepinfo swissprot:THIM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:THIM_ECOLI pepnet swissprot:THIM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:THIM_ECOLI pepstats swissprot:THIM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:THIM_ECOLI pepwheel swissprot:THIM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:THIM_ECOLI pepwindow swissprot:THIM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:THIM_ECOLI sigcleave swissprot:THIM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:THIM_ECOLI ## Database ID URL or Descriptions # AltName DMSO reductase maturation protein {ECO:0000255|HAMAP-Rule MF_00940} # AltName Twin-arginine leader-binding protein DmsD {ECO:0000255|HAMAP-Rule MF_00940} # BioGrid 4259117 3 # EcoGene EG13847 dmsD # FUNCTION DMSD_ECOLI Required for biogenesis/assembly of DMSO reductase, but not for the interaction of the DmsA signal peptide with the Tat system. May be part of a chaperone cascade complex that facilitates a folding-maturation pathway for the substrate protein. {ECO 0000255|HAMAP-Rule MF_00940, ECO 0000269|PubMed 11309116, ECO 0000269|PubMed 12527378, ECO 0000269|PubMed 12813051, ECO 0000269|PubMed 20153451}. # GO_component GO:0005737 cytoplasm; IMP:EcoCyc. # GO_component GO:0031234 extrinsic component of cytoplasmic side of plasma membrane; IMP:EcoCyc. # GO_function GO:0005048 signal sequence binding; IEA:InterPro. # GO_process GO:0061077 chaperone-mediated protein folding; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006457 protein folding # Gene3D 1.10.3480.10 -; 1. # HAMAP MF_00940 DmsD_chaperone # INTERACTION DMSD_ECOLI P18775 dmsA; NbExp=7; IntAct=EBI-4406374, EBI-4411104; C5A1D5 groL (xeno); NbExp=5; IntAct=EBI-4406374, EBI-4406290; C4ZYN1 grpE (xeno); NbExp=4; IntAct=EBI-4406374, EBI-4407105; C4ZTJ3 tig (xeno); NbExp=3; IntAct=EBI-4406374, EBI-4407188; P77374 ynfE; NbExp=3; IntAct=EBI-4406374, EBI-556186; P77783 ynfF; NbExp=2; IntAct=EBI-4406374, EBI-6406285; # IntAct P69853 10 # InterPro IPR020945 DMSO/NO3_reduct_chaperone # InterPro IPR026269 DmsD-type # InterPro IPR028611 DmsD_chaperone # Organism DMSD_ECOLI Escherichia coli (strain K12) # PATRIC 32118484 VBIEscCol129921_1662 # PDB 3CW0 X-ray; 2.40 A; A/B/C/D=1-204 # PDB 3EFP X-ray; 2.01 A; A/B=1-204 # PDB 3U41 X-ray; 2.50 A; A/B/C/D/E/F/G/H=1-204 # PIR A64915 A64915 # PIRSF PIRSF004690 DmsD # Pfam PF02613 Nitrate_red_del # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Tat proofreading chaperone DmsD {ECO:0000255|HAMAP-Rule MF_00940} # RefSeq NP_416108 NC_000913.3 # RefSeq WP_000148710 NZ_LN832404.1 # SIMILARITY Belongs to the TorD/DmsD family. DmsD subfamily. {ECO:0000255|HAMAP-Rule MF_00940}. # SUBCELLULAR LOCATION DMSD_ECOLI Cell inner membrane {ECO 0000269|PubMed 12813051}; Peripheral membrane protein {ECO 0000269|PubMed 12813051}. Cytoplasm {ECO 0000269|PubMed 12813051}. Note=Mainly cytoplasmic under aerobic conditions, and found in the inner membrane under anaerobic conditions. # SUBUNIT DMSD_ECOLI Monomer and homodimer. Binds to the twin-arginine signal peptide of DmsA and TorA (PubMed 11309116), although the latter binding is controversial (PubMed 20169075). Interacts with the TatB and TatC subunits of the Tat translocase complex. Interacts also with other general chaperones, such as GroEL, and proteins involved in the molybdenum cofactor biosynthesis. {ECO 0000269|PubMed 11309116, ECO 0000269|PubMed 12813051, ECO 0000269|PubMed 14766221, ECO 0000269|PubMed 20153451, ECO 0000269|PubMed 20169075}. # SUPFAM SSF89155 SSF89155 # eggNOG COG3381 LUCA # eggNOG ENOG4108NEM Bacteria BLAST swissprot:DMSD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DMSD_ECOLI BioCyc ECOL316407:JW5262-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5262-MONOMER BioCyc EcoCyc:G6849-MONOMER http://biocyc.org/getid?id=EcoCyc:G6849-MONOMER DIP DIP-47840N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47840N DOI 10.1016/S0014-5793(02)03839-5 http://dx.doi.org/10.1016/S0014-5793(02)03839-5 DOI 10.1016/j.bbapap.2010.01.022 http://dx.doi.org/10.1016/j.bbapap.2010.01.022 DOI 10.1016/j.bbrc.2004.01.070 http://dx.doi.org/10.1016/j.bbrc.2004.01.070 DOI 10.1016/j.jmb.2009.03.069 http://dx.doi.org/10.1016/j.jmb.2009.03.069 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2001.02391.x http://dx.doi.org/10.1046/j.1365-2958.2001.02391.x DOI 10.1074/jbc.M301076200 http://dx.doi.org/10.1074/jbc.M301076200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1107/S1744309109023811 http://dx.doi.org/10.1107/S1744309109023811 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pone.0009225 http://dx.doi.org/10.1371/journal.pone.0009225 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3608 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3608 EcoGene EG13847 http://www.ecogene.org/geneInfo.php?eg_id=EG13847 EnsemblBacteria AAC74663 http://www.ensemblgenomes.org/id/AAC74663 EnsemblBacteria AAC74663 http://www.ensemblgenomes.org/id/AAC74663 EnsemblBacteria BAA15315 http://www.ensemblgenomes.org/id/BAA15315 EnsemblBacteria BAA15315 http://www.ensemblgenomes.org/id/BAA15315 EnsemblBacteria BAA15315 http://www.ensemblgenomes.org/id/BAA15315 EnsemblBacteria b1591 http://www.ensemblgenomes.org/id/b1591 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0031234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031234 GO_function GO:0005048 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005048 GO_process GO:0061077 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061077 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 Gene3D 1.10.3480.10 http://www.cathdb.info/version/latest/superfamily/1.10.3480.10 GeneID 945987 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945987 HAMAP MF_00940 http://hamap.expasy.org/unirule/MF_00940 HOGENOM HOG000120828 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120828&db=HOGENOM6 InParanoid P69853 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P69853 IntAct P69853 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69853* InterPro IPR020945 http://www.ebi.ac.uk/interpro/entry/IPR020945 InterPro IPR026269 http://www.ebi.ac.uk/interpro/entry/IPR026269 InterPro IPR028611 http://www.ebi.ac.uk/interpro/entry/IPR028611 KEGG_Gene ecj:JW5262 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5262 KEGG_Gene eco:b1591 http://www.genome.jp/dbget-bin/www_bget?eco:b1591 MINT MINT-8046358 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8046358 OMA AWHLLPW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AWHLLPW PDB 3CW0 http://www.ebi.ac.uk/pdbe-srv/view/entry/3CW0 PDB 3EFP http://www.ebi.ac.uk/pdbe-srv/view/entry/3EFP PDB 3U41 http://www.ebi.ac.uk/pdbe-srv/view/entry/3U41 PDBsum 3CW0 http://www.ebi.ac.uk/pdbsum/3CW0 PDBsum 3EFP http://www.ebi.ac.uk/pdbsum/3EFP PDBsum 3U41 http://www.ebi.ac.uk/pdbsum/3U41 PSORT swissprot:DMSD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DMSD_ECOLI PSORT-B swissprot:DMSD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DMSD_ECOLI PSORT2 swissprot:DMSD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DMSD_ECOLI Pfam PF02613 http://pfam.xfam.org/family/PF02613 Phobius swissprot:DMSD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DMSD_ECOLI PhylomeDB P69853 http://phylomedb.org/?seqid=P69853 ProteinModelPortal P69853 http://www.proteinmodelportal.org/query/uniprot/P69853 PubMed 11309116 http://www.ncbi.nlm.nih.gov/pubmed/11309116 PubMed 12527378 http://www.ncbi.nlm.nih.gov/pubmed/12527378 PubMed 12813051 http://www.ncbi.nlm.nih.gov/pubmed/12813051 PubMed 14766221 http://www.ncbi.nlm.nih.gov/pubmed/14766221 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19361518 http://www.ncbi.nlm.nih.gov/pubmed/19361518 PubMed 19652330 http://www.ncbi.nlm.nih.gov/pubmed/19652330 PubMed 20153451 http://www.ncbi.nlm.nih.gov/pubmed/20153451 PubMed 20169075 http://www.ncbi.nlm.nih.gov/pubmed/20169075 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416108 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416108 RefSeq WP_000148710 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000148710 SMR P69853 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69853 STRING 511145.b1591 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1591&targetmode=cogs SUPFAM SSF89155 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF89155 UniProtKB DMSD_ECOLI http://www.uniprot.org/uniprot/DMSD_ECOLI UniProtKB-AC P69853 http://www.uniprot.org/uniprot/P69853 charge swissprot:DMSD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DMSD_ECOLI eggNOG COG3381 http://eggnogapi.embl.de/nog_data/html/tree/COG3381 eggNOG ENOG4108NEM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108NEM epestfind swissprot:DMSD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DMSD_ECOLI garnier swissprot:DMSD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DMSD_ECOLI helixturnhelix swissprot:DMSD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DMSD_ECOLI hmoment swissprot:DMSD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DMSD_ECOLI iep swissprot:DMSD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DMSD_ECOLI inforesidue swissprot:DMSD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DMSD_ECOLI octanol swissprot:DMSD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DMSD_ECOLI pepcoil swissprot:DMSD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DMSD_ECOLI pepdigest swissprot:DMSD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DMSD_ECOLI pepinfo swissprot:DMSD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DMSD_ECOLI pepnet swissprot:DMSD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DMSD_ECOLI pepstats swissprot:DMSD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DMSD_ECOLI pepwheel swissprot:DMSD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DMSD_ECOLI pepwindow swissprot:DMSD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DMSD_ECOLI sigcleave swissprot:DMSD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DMSD_ECOLI ## Database ID URL or Descriptions # BioGrid 4261788 11 # EcoGene EG11649 yafC # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; ISS:EcoCyc. # GO_process GO:0010212 response to ionizing radiation; IMP:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # IntAct P30864 6 # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR005119 LysR_subst-bd # InterPro IPR011991 WHTH_DNA-bd_dom # Organism YAFC_ECOLI Escherichia coli (strain K12) # PATRIC 32115529 VBIEscCol129921_0210 # PIR JS0716 JS0716 # PRINTS PR00039 HTHLYSR # PROSITE PS50931 HTH_LYSR # Pfam PF00126 HTH_1 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAFC_ECOLI Uncharacterized HTH-type transcriptional regulator YafC # RefSeq NP_414744 NC_000913.3 # RefSeq WP_000648572 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lysR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00253}. # SUPFAM SSF46785 SSF46785 # eggNOG ENOG4105HEI Bacteria # eggNOG ENOG410XRV0 LUCA BLAST swissprot:YAFC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAFC_ECOLI BioCyc ECOL316407:JW0198-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0198-MONOMER BioCyc EcoCyc:EG11649-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11649-MONOMER DIP DIP-11210N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11210N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D12650 http://www.ebi.ac.uk/ena/data/view/D12650 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EchoBASE EB1602 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1602 EcoGene EG11649 http://www.ecogene.org/geneInfo.php?eg_id=EG11649 EnsemblBacteria AAC73313 http://www.ensemblgenomes.org/id/AAC73313 EnsemblBacteria AAC73313 http://www.ensemblgenomes.org/id/AAC73313 EnsemblBacteria BAA77879 http://www.ensemblgenomes.org/id/BAA77879 EnsemblBacteria BAA77879 http://www.ensemblgenomes.org/id/BAA77879 EnsemblBacteria BAA77879 http://www.ensemblgenomes.org/id/BAA77879 EnsemblBacteria b0208 http://www.ensemblgenomes.org/id/b0208 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0010212 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010212 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 947507 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947507 HOGENOM HOG000233519 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000233519&db=HOGENOM6 InParanoid P30864 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30864 IntAct P30864 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P30864* InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW0198 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0198 KEGG_Gene eco:b0208 http://www.genome.jp/dbget-bin/www_bget?eco:b0208 MINT MINT-1323766 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1323766 OMA PVILHFL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PVILHFL PRINTS PR00039 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00039 PROSITE PS50931 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50931 PSORT swissprot:YAFC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAFC_ECOLI PSORT-B swissprot:YAFC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAFC_ECOLI PSORT2 swissprot:YAFC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAFC_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:YAFC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAFC_ECOLI PhylomeDB P30864 http://phylomedb.org/?seqid=P30864 ProteinModelPortal P30864 http://www.proteinmodelportal.org/query/uniprot/P30864 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414744 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414744 RefSeq WP_000648572 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000648572 SMR P30864 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P30864 STRING 511145.b0208 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0208&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB YAFC_ECOLI http://www.uniprot.org/uniprot/YAFC_ECOLI UniProtKB-AC P30864 http://www.uniprot.org/uniprot/P30864 charge swissprot:YAFC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAFC_ECOLI eggNOG ENOG4105HEI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105HEI eggNOG ENOG410XRV0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRV0 epestfind swissprot:YAFC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAFC_ECOLI garnier swissprot:YAFC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAFC_ECOLI helixturnhelix swissprot:YAFC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAFC_ECOLI hmoment swissprot:YAFC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAFC_ECOLI iep swissprot:YAFC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAFC_ECOLI inforesidue swissprot:YAFC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAFC_ECOLI octanol swissprot:YAFC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAFC_ECOLI pepcoil swissprot:YAFC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAFC_ECOLI pepdigest swissprot:YAFC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAFC_ECOLI pepinfo swissprot:YAFC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAFC_ECOLI pepnet swissprot:YAFC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAFC_ECOLI pepstats swissprot:YAFC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAFC_ECOLI pepwheel swissprot:YAFC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAFC_ECOLI pepwindow swissprot:YAFC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAFC_ECOLI sigcleave swissprot:YAFC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAFC_ECOLI ## Database ID URL or Descriptions # BioGrid 4260889 297 # EcoGene EG14341 ymgF # FUNCTION YMGF_ECOLI Could be involved in cell division. May participate in the stabilization of the cell divisome under specific conditions. {ECO 0000269|PubMed 18978050}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0007049 cell cycle; IEA:UniProtKB-KW. # GO_process GO:0051301 cell division; IGI:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0007049 cell cycle # GOslim_process GO:0051301 cell division # INTERACTION YMGF_ECOLI P0AD68 ftsI; NbExp=3; IntAct=EBI-1214577, EBI-548564; P0AEN4 ftsL; NbExp=3; IntAct=EBI-1214577, EBI-1119082; P06136 ftsQ; NbExp=3; IntAct=EBI-1214577, EBI-1130157; # IntAct P58034 9 # Organism YMGF_ECOLI Escherichia coli (strain K12) # PATRIC 32117573 VBIEscCol129921_1209 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YMGF_ECOLI Inner membrane protein YmgF # RefSeq WP_001065861 NZ_LN832404.1 # RefSeq YP_588447 NC_000913.3 # SUBCELLULAR LOCATION YMGF_ECOLI Cell inner membrane {ECO 0000269|PubMed 18978050}; Multi-pass membrane protein {ECO 0000269|PubMed 18978050}. Note=Localizes to the division septum. Localization requires FtsZ, FtsA, FTsQ and FtsN. # SUBUNIT YMGF_ECOLI Interacts with FtsL, FtsQ, FtsI, FtsN, and probably many other cell division proteins. {ECO 0000269|PubMed 15774864, ECO 0000269|PubMed 18978050}. BLAST swissprot:YMGF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YMGF_ECOLI BioCyc ECOL316407:JW1156-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1156-MONOMER BioCyc EcoCyc:MONOMER0-2141 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2141 DIP DIP-12735N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12735N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00331-08 http://dx.doi.org/10.1128/JB.00331-08 DOI 10.1128/JB.187.7.2233-2243.2005 http://dx.doi.org/10.1128/JB.187.7.2233-2243.2005 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14341 http://www.ecogene.org/geneInfo.php?eg_id=EG14341 EnsemblBacteria ABD18651 http://www.ensemblgenomes.org/id/ABD18651 EnsemblBacteria ABD18651 http://www.ensemblgenomes.org/id/ABD18651 EnsemblBacteria BAE76388 http://www.ensemblgenomes.org/id/BAE76388 EnsemblBacteria BAE76388 http://www.ensemblgenomes.org/id/BAE76388 EnsemblBacteria BAE76388 http://www.ensemblgenomes.org/id/BAE76388 EnsemblBacteria b4520 http://www.ensemblgenomes.org/id/b4520 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GeneID 1450253 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1450253 HOGENOM HOG000009428 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009428&db=HOGENOM6 IntAct P58034 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P58034* KEGG_Gene ecj:JW1156 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1156 KEGG_Gene eco:b4520 http://www.genome.jp/dbget-bin/www_bget?eco:b4520 OMA FINAVMW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FINAVMW PSORT swissprot:YMGF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YMGF_ECOLI PSORT-B swissprot:YMGF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YMGF_ECOLI PSORT2 swissprot:YMGF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YMGF_ECOLI Phobius swissprot:YMGF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YMGF_ECOLI ProteinModelPortal P58034 http://www.proteinmodelportal.org/query/uniprot/P58034 PubMed 15774864 http://www.ncbi.nlm.nih.gov/pubmed/15774864 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18978050 http://www.ncbi.nlm.nih.gov/pubmed/18978050 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001065861 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001065861 RefSeq YP_588447 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_588447 STRING 511145.b4520 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4520&targetmode=cogs UniProtKB YMGF_ECOLI http://www.uniprot.org/uniprot/YMGF_ECOLI UniProtKB-AC P58034 http://www.uniprot.org/uniprot/P58034 charge swissprot:YMGF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YMGF_ECOLI epestfind swissprot:YMGF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YMGF_ECOLI garnier swissprot:YMGF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YMGF_ECOLI helixturnhelix swissprot:YMGF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YMGF_ECOLI hmoment swissprot:YMGF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YMGF_ECOLI iep swissprot:YMGF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YMGF_ECOLI inforesidue swissprot:YMGF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YMGF_ECOLI octanol swissprot:YMGF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YMGF_ECOLI pepcoil swissprot:YMGF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YMGF_ECOLI pepdigest swissprot:YMGF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YMGF_ECOLI pepinfo swissprot:YMGF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YMGF_ECOLI pepnet swissprot:YMGF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YMGF_ECOLI pepstats swissprot:YMGF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YMGF_ECOLI pepwheel swissprot:YMGF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YMGF_ECOLI pepwindow swissprot:YMGF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YMGF_ECOLI sigcleave swissprot:YMGF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YMGF_ECOLI ## Database ID URL or Descriptions # AltName HCHA_ECOLI Glyoxalase III {ECO 0000303|PubMed 21696459, ECO 0000303|PubMed 7848303} # AltName Holding molecular chaperone {ECO:0000303|PubMed 14731284} # AltName Hsp31 {ECO:0000303|PubMed 12235139} # BIOPHYSICOCHEMICAL PROPERTIES HCHA_ECOLI Kinetic parameters KM=55 uM for Lys-AMC (at 37 degrees Celsius and pH 8.5) {ECO 0000269|PubMed 15550391}; KM=95 uM for Arg-AMC (at 37 degrees Celsius and pH 8.5) {ECO 0000269|PubMed 15550391}; KM=120 uM for Ala-AMC (at 37 degrees Celsius and pH 8.5) {ECO 0000269|PubMed 15550391}; KM=1.43 mM for methylglyoxal {ECO 0000269|PubMed 21696459}; Note=kcat is 156.9 min(-1) for glyoxalase activity with methylglyoxal as substrate (PubMed 21696459). kcat is 0.43 min(- 1) for aminopeptidase activity with Lys-AMC as substrate. kcat is 0.51 min(-1) for aminopeptidase activity with Arg-AMC as substrate. kcat is 1.1 min(-1) for aminopeptidase activity with Ala-AMC as substrate (PubMed 15550391). {ECO 0000269|PubMed 15550391, ECO 0000269|PubMed 21696459}; pH dependence Optimum pH is between 6 and 8 for glyoxalase activity (PubMed 21696459, PubMed 7848303). Significant inhibition of glyoxalase activity below pH 5 (PubMed 21696459). Optimum pH is 8 for aminopeptidase activity (PubMed 15550391). {ECO 0000269|PubMed 15550391, ECO 0000269|PubMed 21696459, ECO 0000269|PubMed 7848303}; Temperature dependence Optimum temperature for glyoxalase activity is around 37 degrees Celsius (PubMed 21696459). Optimum temperature for aminopeptidase activity is around 43 degrees Celsius (PubMed 15550391). {ECO 0000269|PubMed 15550391, ECO 0000269|PubMed 21696459}; # BioGrid 4260394 20 # CATALYTIC ACTIVITY HCHA_ECOLI (R)-lactate = methylglyoxal + H(2)O. {ECO 0000269|PubMed 21696459, ECO 0000269|PubMed 7848303}. # DISRUPTION PHENOTYPE HCHA_ECOLI Cells lacking this gene show a loss of glyoxalase and reduction in aminopeptidase activity (PubMed 15550391, PubMed 21696459). They accumulate methylglyoxal and are more susceptible to methylglyoxal than the parent strain (PubMed 21696459). Cells exhibit growth defects above 48 degrees Celsius and accumulate higher levels of peptides than wild-type (PubMed 14731284, PubMed 15550391). They display increased glycation levels (PubMed 26102038). Moreover, the double and triple mutants lacking yhbO and yajL, and yhbO, yajL and hchA, respectively, display impressive amounts of glycated proteins, suggesting that the YhbO, YajL and Hsp31 deglycases display relatively redundant functions (PubMed 26774339). They hchA mutant cells show decreased viability in methylglyoxal- or glucose- containing media (PubMed 26774339). {ECO 0000269|PubMed 14731284, ECO 0000269|PubMed 15550391, ECO 0000269|PubMed 21696459, ECO 0000269|PubMed 26102038, ECO 0000269|PubMed 26774339}. # DOMAIN HCHA_ECOLI Consists of a large A domain and a smaller P domain connected by a linker. The thermally induced motion of the flexible linker-loop region leads to the uncovering of a high- affinity substrate-binding site that is essential to capture nonnative proteins at high temperatures. {ECO 0000269|PubMed 15173574}. # ENZYME REGULATION HCHA_ECOLI The glyoxalase activity is inhibited by copper and zinc cations, activated by ferrous cations, and inactivated by thiol-blocking reagents (PubMed 21696459, PubMed 7848303). The aminopeptidase activity is inhibited by iodoacetamide, dithiothreitol, EDTA and 1, 10-phenanthroline (PubMed 15550391). Binding of ATP at high temperatures induces a conformational change that reduces HchA surface hydrophobicity, interferes with its ability to capture substrate proteins and inhibits chaperone activity (PubMed 12235139). {ECO 0000269|PubMed 12235139, ECO 0000269|PubMed 15550391, ECO 0000269|PubMed 21696459, ECO 0000269|PubMed 7848303}. # EcoGene EG11755 hchA # FUNCTION HCHA_ECOLI Protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Is able to repair glycated serum albumin, aspartate aminotransferase, glyceraldehyde-3-phosphate dehydrogenase, and fructose biphosphate aldolase. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of Schiff bases and advanced glycation endproducts (AGE) (PubMed 26102038, PubMed 26774339). Has been reported to display chaperone, peptidase and glutathione-independent glyoxalase activities (PubMed 12235139, PubMed 12565879, PubMed 14731284, PubMed 15550391, PubMed 7848303, PubMed 21696459). However, these apparently disparate activities are all recruited to execute its protein deglycase primary function (PubMed 26102038, PubMed 26774339). Plays an important role in protecting cells from carbonyl stress, severe heat shock and starvation, as well as in acid resistance of stationary-phase cells (PubMed 12235139, PubMed 16796689, PubMed 17158627). {ECO 0000269|PubMed 12235139, ECO 0000269|PubMed 12565879, ECO 0000269|PubMed 14731284, ECO 0000269|PubMed 15550391, ECO 0000269|PubMed 16796689, ECO 0000269|PubMed 17158627, ECO 0000269|PubMed 21696459, ECO 0000269|PubMed 26102038, ECO 0000269|PubMed 26774339, ECO 0000269|PubMed 7848303}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0008270 zinc ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0016790 thiolester hydrolase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; IEA:UniProtKB-HAMAP. # GO_function GO:0019172 glyoxalase III activity; IDA:EcoCyc. # GO_process GO:0010447 response to acidic pH; IMP:EcoCyc. # GO_process GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione; IMP:EcoCyc. # GO_process GO:0030091 protein repair; IEA:UniProtKB-HAMAP. # GO_process GO:0051595 response to methylglyoxal; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.880 -; 1. # HAMAP MF_01046 Prot_deglyc_HchA # INDUCTION HCHA_ECOLI By heat shock. # INTERACTION HCHA_ECOLI P0ACI6 asnC; NbExp=2; IntAct=EBI-909144, EBI-1133670; # IntAct P31658 32 # InterPro IPR017283 HchA # InterPro IPR029062 Class_I_gatase-like # MISCELLANEOUS HCHA_ECOLI According to some authors, HchA exhibits an exceedingly weak proteolytic activity against bovine serum albumin (BSA) and some peptidase activity against small single amino acids conjugated to a fluorogenic reporter (PubMed 12939276). Another report showed that HchA does not display any significant proteolytic activity but displays a physiologically relevant aminopeptidase activity (PubMed 15550391). {ECO 0000305|PubMed 12939276, ECO 0000305|PubMed 15550391}. # Organism HCHA_ECOLI Escherichia coli (strain K12) # PATRIC 32119265 VBIEscCol129921_2047 # PDB 1IZY X-ray; 2.80 A; A/B=1-283 # PDB 1IZZ X-ray; 2.31 A; A=1-283 # PDB 1N57 X-ray; 1.60 A; A=1-283 # PDB 1ONS X-ray; 2.20 A; A=2-283 # PDB 1PV2 X-ray; 2.71 A; A/B/C/D/E/F/G/H=1-283 # PIR C64961 C64961 # PIRSF PIRSF037798 Chaperone_HchA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Protein deglycase 1 {ECO:0000303|PubMed 26774339} # RefSeq NP_416476 NC_000913.3 # RefSeq WP_000218212 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase C56 family. HchA subfamily. {ECO:0000255|HAMAP-Rule MF_01046}. # SUBCELLULAR LOCATION HCHA_ECOLI Cytoplasm. # SUBUNIT HCHA_ECOLI Homodimer. {ECO 0000269|PubMed 12235139, ECO 0000269|PubMed 12565879, ECO 0000269|PubMed 7848303}. # SUPFAM SSF52317 SSF52317 # eggNOG COG0693 LUCA # eggNOG ENOG4105TMR Bacteria BLAST swissprot:HCHA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HCHA_ECOLI BioCyc ECOL316407:JW1950-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1950-MONOMER BioCyc EcoCyc:G7055-MONOMER http://biocyc.org/getid?id=EcoCyc:G7055-MONOMER BioCyc MetaCyc:G7055-MONOMER http://biocyc.org/getid?id=MetaCyc:G7055-MONOMER COG COG0693 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0693 DIP DIP-11851N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11851N DOI 10.1007/BF00282791 http://dx.doi.org/10.1007/BF00282791 DOI 10.1016/S0006-291X(02)03053-X http://dx.doi.org/10.1016/S0006-291X(02)03053-X DOI 10.1016/j.bbrc.2015.06.111 http://dx.doi.org/10.1016/j.bbrc.2015.06.111 DOI 10.1016/j.bbrc.2016.01.068 http://dx.doi.org/10.1016/j.bbrc.2016.01.068 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj3050999 http://dx.doi.org/10.1042/bj3050999 DOI 10.1046/j.1365-2958.2003.03871.x http://dx.doi.org/10.1046/j.1365-2958.2003.03871.x DOI 10.1073/pnas.0403033101 http://dx.doi.org/10.1073/pnas.0403033101 DOI 10.1073/pnas.0530312100 http://dx.doi.org/10.1073/pnas.0530312100 DOI 10.1074/jbc.M205800200 http://dx.doi.org/10.1074/jbc.M205800200 DOI 10.1074/jbc.M304517200 http://dx.doi.org/10.1074/jbc.M304517200 DOI 10.1074/jbc.M408296200 http://dx.doi.org/10.1074/jbc.M408296200 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1107/S0907444902007369 http://dx.doi.org/10.1107/S0907444902007369 DOI 10.1110/ps.03121403 http://dx.doi.org/10.1110/ps.03121403 DOI 10.1110/ps.03399604 http://dx.doi.org/10.1110/ps.03399604 DOI 10.1111/j.1365-2958.2006.05207.x http://dx.doi.org/10.1111/j.1365-2958.2006.05207.x DOI 10.1111/j.1365-2958.2011.07736.x http://dx.doi.org/10.1111/j.1365-2958.2011.07736.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AEM.02429-06 http://dx.doi.org/10.1128/AEM.02429-06 EC_number EC:3.1.2.- {ECO:0000305|PubMed:26102038, ECO:0000305|PubMed:26774339} http://www.genome.jp/dbget-bin/www_bget?EC:3.1.2.- {ECO:0000305|PubMed:26102038, ECO:0000305|PubMed:26774339} EC_number EC:3.5.1.- {ECO:0000305|PubMed:26102038, ECO:0000305|PubMed:26774339} http://www.genome.jp/dbget-bin/www_bget?EC:3.5.1.- {ECO:0000305|PubMed:26102038, ECO:0000305|PubMed:26774339} EC_number EC:4.2.1.130 {ECO:0000269|PubMed:21696459, ECO:0000269|PubMed:7848303} http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.130 {ECO:0000269|PubMed:21696459, ECO:0000269|PubMed:7848303} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.2.- {ECO:0000305|PubMed:26102038, ECO:0000305|PubMed:26774339} http://enzyme.expasy.org/EC/3.1.2.- {ECO:0000305|PubMed:26102038, ECO:0000305|PubMed:26774339} ENZYME 3.5.1.- {ECO:0000305|PubMed:26102038, ECO:0000305|PubMed:26774339} http://enzyme.expasy.org/EC/3.5.1.- {ECO:0000305|PubMed:26102038, ECO:0000305|PubMed:26774339} ENZYME 4.2.1.130 {ECO:0000269|PubMed:21696459, ECO:0000269|PubMed:7848303} http://enzyme.expasy.org/EC/4.2.1.130 {ECO:0000269|PubMed:21696459, ECO:0000269|PubMed:7848303} EchoBASE EB1705 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1705 EcoGene EG11755 http://www.ecogene.org/geneInfo.php?eg_id=EG11755 EnsemblBacteria AAC75033 http://www.ensemblgenomes.org/id/AAC75033 EnsemblBacteria AAC75033 http://www.ensemblgenomes.org/id/AAC75033 EnsemblBacteria BAA15794 http://www.ensemblgenomes.org/id/BAA15794 EnsemblBacteria BAA15794 http://www.ensemblgenomes.org/id/BAA15794 EnsemblBacteria BAA15794 http://www.ensemblgenomes.org/id/BAA15794 EnsemblBacteria b1967 http://www.ensemblgenomes.org/id/b1967 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0016790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016790 GO_function GO:0016811 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016811 GO_function GO:0019172 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019172 GO_process GO:0010447 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010447 GO_process GO:0019243 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019243 GO_process GO:0030091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030091 GO_process GO:0051595 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051595 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.880 http://www.cathdb.info/version/latest/superfamily/3.40.50.880 GeneID 946481 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946481 HAMAP MF_01046 http://hamap.expasy.org/unirule/MF_01046 HOGENOM HOG000221774 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000221774&db=HOGENOM6 InParanoid P31658 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31658 IntAct P31658 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31658* IntEnz 3.1.2.- {ECO:0000305|PubMed:26102038, ECO:0000305|PubMed:26774339} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.2.- {ECO:0000305|PubMed:26102038, ECO:0000305|PubMed:26774339} IntEnz 3.5.1.- {ECO:0000305|PubMed:26102038, ECO:0000305|PubMed:26774339} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.1.- {ECO:0000305|PubMed:26102038, ECO:0000305|PubMed:26774339} IntEnz 4.2.1.130 {ECO:0000269|PubMed:21696459, ECO:0000269|PubMed:7848303} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.130 {ECO:0000269|PubMed:21696459, ECO:0000269|PubMed:7848303} InterPro IPR017283 http://www.ebi.ac.uk/interpro/entry/IPR017283 InterPro IPR029062 http://www.ebi.ac.uk/interpro/entry/IPR029062 KEGG_Gene ecj:JW1950 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1950 KEGG_Gene eco:b1967 http://www.genome.jp/dbget-bin/www_bget?eco:b1967 KEGG_Orthology KO:K05523 http://www.genome.jp/dbget-bin/www_bget?KO:K05523 OMA PMYHLDK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PMYHLDK PDB 1IZY http://www.ebi.ac.uk/pdbe-srv/view/entry/1IZY PDB 1IZZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1IZZ PDB 1N57 http://www.ebi.ac.uk/pdbe-srv/view/entry/1N57 PDB 1ONS http://www.ebi.ac.uk/pdbe-srv/view/entry/1ONS PDB 1PV2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1PV2 PDBsum 1IZY http://www.ebi.ac.uk/pdbsum/1IZY PDBsum 1IZZ http://www.ebi.ac.uk/pdbsum/1IZZ PDBsum 1N57 http://www.ebi.ac.uk/pdbsum/1N57 PDBsum 1ONS http://www.ebi.ac.uk/pdbsum/1ONS PDBsum 1PV2 http://www.ebi.ac.uk/pdbsum/1PV2 PSORT swissprot:HCHA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HCHA_ECOLI PSORT-B swissprot:HCHA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HCHA_ECOLI PSORT2 swissprot:HCHA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HCHA_ECOLI Phobius swissprot:HCHA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HCHA_ECOLI ProteinModelPortal P31658 http://www.proteinmodelportal.org/query/uniprot/P31658 PubMed 12077448 http://www.ncbi.nlm.nih.gov/pubmed/12077448 PubMed 12235139 http://www.ncbi.nlm.nih.gov/pubmed/12235139 PubMed 12565879 http://www.ncbi.nlm.nih.gov/pubmed/12565879 PubMed 12621151 http://www.ncbi.nlm.nih.gov/pubmed/12621151 PubMed 12939276 http://www.ncbi.nlm.nih.gov/pubmed/12939276 PubMed 14500888 http://www.ncbi.nlm.nih.gov/pubmed/14500888 PubMed 14691241 http://www.ncbi.nlm.nih.gov/pubmed/14691241 PubMed 14731284 http://www.ncbi.nlm.nih.gov/pubmed/14731284 PubMed 15173574 http://www.ncbi.nlm.nih.gov/pubmed/15173574 PubMed 15550391 http://www.ncbi.nlm.nih.gov/pubmed/15550391 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16796689 http://www.ncbi.nlm.nih.gov/pubmed/16796689 PubMed 17158627 http://www.ncbi.nlm.nih.gov/pubmed/17158627 PubMed 21696459 http://www.ncbi.nlm.nih.gov/pubmed/21696459 PubMed 26102038 http://www.ncbi.nlm.nih.gov/pubmed/26102038 PubMed 26774339 http://www.ncbi.nlm.nih.gov/pubmed/26774339 PubMed 7848303 http://www.ncbi.nlm.nih.gov/pubmed/7848303 PubMed 8455549 http://www.ncbi.nlm.nih.gov/pubmed/8455549 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416476 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416476 RefSeq WP_000218212 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000218212 SMR P31658 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31658 STRING 511145.b1967 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1967&targetmode=cogs STRING COG0693 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0693&targetmode=cogs SUPFAM SSF52317 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52317 SWISS-2DPAGE P31658 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P31658 UniProtKB HCHA_ECOLI http://www.uniprot.org/uniprot/HCHA_ECOLI UniProtKB-AC P31658 http://www.uniprot.org/uniprot/P31658 charge swissprot:HCHA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HCHA_ECOLI eggNOG COG0693 http://eggnogapi.embl.de/nog_data/html/tree/COG0693 eggNOG ENOG4105TMR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105TMR epestfind swissprot:HCHA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HCHA_ECOLI garnier swissprot:HCHA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HCHA_ECOLI helixturnhelix swissprot:HCHA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HCHA_ECOLI hmoment swissprot:HCHA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HCHA_ECOLI iep swissprot:HCHA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HCHA_ECOLI inforesidue swissprot:HCHA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HCHA_ECOLI octanol swissprot:HCHA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HCHA_ECOLI pepcoil swissprot:HCHA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HCHA_ECOLI pepdigest swissprot:HCHA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HCHA_ECOLI pepinfo swissprot:HCHA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HCHA_ECOLI pepnet swissprot:HCHA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HCHA_ECOLI pepstats swissprot:HCHA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HCHA_ECOLI pepwheel swissprot:HCHA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HCHA_ECOLI pepwindow swissprot:HCHA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HCHA_ECOLI sigcleave swissprot:HCHA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HCHA_ECOLI ## Database ID URL or Descriptions # AltName AVTA_ECOLI Alanine--valine transaminase # AltName AVTA_ECOLI Transaminase C # BioGrid 4259371 139 # CATALYTIC ACTIVITY AVTA_ECOLI L-valine + pyruvate = 3-methyl-2-oxobutanoate + L-alanine. # COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI 597326; # EcoGene EG10107 avtA # FUNCTION AVTA_ECOLI Involved in the biosynthesis of alanine. {ECO 0000269|PubMed 13034817, ECO 0000269|PubMed 20729367}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0009042 valine-pyruvate transaminase activity; IDA:EcoCyc. # GO_function GO:0030170 pyridoxal phosphate binding; IEA:InterPro. # GO_process GO:0030632 D-alanine biosynthetic process; IMP:UniProtKB. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.640.10 -; 1. # Gene3D 3.90.1150.10 -; 1. # INDUCTION AVTA_ECOLI Modestly repressed by alanine and leucine via Lrp. Amino acid limitation causes repression by promoting the accumulation of L-alanine or L-leucine or both. AvtA is also repressed by L-alpha-aminobutyric acid and other nonprotein amino acids which are structurally similar to L-alanine. {ECO 0000269|PubMed 20729367, ECO 0000269|PubMed 6373721}. # InterPro IPR004839 Aminotransferase_I/II # InterPro IPR015421 PyrdxlP-dep_Trfase_major_sub1 # InterPro IPR015422 PyrdxlP-dep_Trfase_major_sub2 # InterPro IPR015424 PyrdxlP-dep_Trfase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01007 Amino acid related enzymes # KEGG_Pathway ko00290 Valine, leucine and isoleucine biosynthesis # Organism AVTA_ECOLI Escherichia coli (strain K12) # PATRIC 32122620 VBIEscCol129921_3687 # PIR S47793 S47793 # Pfam PF00155 Aminotran_1_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AVTA_ECOLI Valine--pyruvate aminotransferase # RefSeq WP_000144363 NZ_LN832404.1 # RefSeq YP_026231 NC_000913.3 # SEQUENCE CAUTION Sequence=CAA68546.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=CAA68546.1; Type=Miscellaneous discrepancy; Evidence={ECO 0000305}; # SIMILARITY Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. {ECO 0000305}. # SUBCELLULAR LOCATION AVTA_ECOLI Cytoplasm {ECO 0000250}. # SUBUNIT Homodimer. {ECO 0000250}. # SUPFAM SSF53383 SSF53383 # eggNOG COG3977 LUCA # eggNOG ENOG4105JKW Bacteria BLAST swissprot:AVTA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AVTA_ECOLI BioCyc ECOL316407:JW5652-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5652-MONOMER BioCyc EcoCyc:VALINE-PYRUVATE-AMINOTRANSFER-MONOMER http://biocyc.org/getid?id=EcoCyc:VALINE-PYRUVATE-AMINOTRANSFER-MONOMER BioCyc MetaCyc:VALINE-PYRUVATE-AMINOTRANSFER-MONOMER http://biocyc.org/getid?id=MetaCyc:VALINE-PYRUVATE-AMINOTRANSFER-MONOMER COG COG0436 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0436 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/15.22.9461 http://dx.doi.org/10.1093/nar/15.22.9461 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00738-10 http://dx.doi.org/10.1128/JB.00738-10 EC_number EC:2.6.1.66 http://www.genome.jp/dbget-bin/www_bget?EC:2.6.1.66 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL Y00490 http://www.ebi.ac.uk/ena/data/view/Y00490 ENZYME 2.6.1.66 http://enzyme.expasy.org/EC/2.6.1.66 EchoBASE EB0105 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0105 EcoGene EG10107 http://www.ecogene.org/geneInfo.php?eg_id=EG10107 EnsemblBacteria AAT48193 http://www.ensemblgenomes.org/id/AAT48193 EnsemblBacteria AAT48193 http://www.ensemblgenomes.org/id/AAT48193 EnsemblBacteria BAE77721 http://www.ensemblgenomes.org/id/BAE77721 EnsemblBacteria BAE77721 http://www.ensemblgenomes.org/id/BAE77721 EnsemblBacteria BAE77721 http://www.ensemblgenomes.org/id/BAE77721 EnsemblBacteria b3572 http://www.ensemblgenomes.org/id/b3572 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0009042 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009042 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_process GO:0030632 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030632 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.640.10 http://www.cathdb.info/version/latest/superfamily/3.40.640.10 Gene3D 3.90.1150.10 http://www.cathdb.info/version/latest/superfamily/3.90.1150.10 GeneID 948087 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948087 HOGENOM HOG000269357 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000269357&db=HOGENOM6 InParanoid P09053 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P09053 IntAct P09053 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P09053* IntEnz 2.6.1.66 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.6.1.66 InterPro IPR004839 http://www.ebi.ac.uk/interpro/entry/IPR004839 InterPro IPR015421 http://www.ebi.ac.uk/interpro/entry/IPR015421 InterPro IPR015422 http://www.ebi.ac.uk/interpro/entry/IPR015422 InterPro IPR015424 http://www.ebi.ac.uk/interpro/entry/IPR015424 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Gene ecj:JW5652 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5652 KEGG_Gene eco:b3572 http://www.genome.jp/dbget-bin/www_bget?eco:b3572 KEGG_Orthology KO:K00835 http://www.genome.jp/dbget-bin/www_bget?KO:K00835 KEGG_Pathway ko00290 http://www.genome.jp/kegg-bin/show_pathway?ko00290 KEGG_Reaction rn:R01215 http://www.genome.jp/dbget-bin/www_bget?rn:R01215 OMA HAHQCLR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HAHQCLR PSORT swissprot:AVTA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AVTA_ECOLI PSORT-B swissprot:AVTA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AVTA_ECOLI PSORT2 swissprot:AVTA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AVTA_ECOLI Pfam PF00155 http://pfam.xfam.org/family/PF00155 Phobius swissprot:AVTA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AVTA_ECOLI PhylomeDB P09053 http://phylomedb.org/?seqid=P09053 ProteinModelPortal P09053 http://www.proteinmodelportal.org/query/uniprot/P09053 PubMed 13034817 http://www.ncbi.nlm.nih.gov/pubmed/13034817 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20729367 http://www.ncbi.nlm.nih.gov/pubmed/20729367 PubMed 2825136 http://www.ncbi.nlm.nih.gov/pubmed/2825136 PubMed 6373721 http://www.ncbi.nlm.nih.gov/pubmed/6373721 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000144363 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000144363 RefSeq YP_026231 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026231 SMR P09053 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P09053 STRING 511145.b3572 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3572&targetmode=cogs STRING COG0436 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0436&targetmode=cogs SUPFAM SSF53383 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53383 UniProtKB AVTA_ECOLI http://www.uniprot.org/uniprot/AVTA_ECOLI UniProtKB-AC P09053 http://www.uniprot.org/uniprot/P09053 charge swissprot:AVTA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AVTA_ECOLI eggNOG COG3977 http://eggnogapi.embl.de/nog_data/html/tree/COG3977 eggNOG ENOG4105JKW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105JKW epestfind swissprot:AVTA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AVTA_ECOLI garnier swissprot:AVTA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AVTA_ECOLI helixturnhelix swissprot:AVTA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AVTA_ECOLI hmoment swissprot:AVTA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AVTA_ECOLI iep swissprot:AVTA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AVTA_ECOLI inforesidue swissprot:AVTA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AVTA_ECOLI octanol swissprot:AVTA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AVTA_ECOLI pepcoil swissprot:AVTA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AVTA_ECOLI pepdigest swissprot:AVTA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AVTA_ECOLI pepinfo swissprot:AVTA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AVTA_ECOLI pepnet swissprot:AVTA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AVTA_ECOLI pepstats swissprot:AVTA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AVTA_ECOLI pepwheel swissprot:AVTA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AVTA_ECOLI pepwindow swissprot:AVTA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AVTA_ECOLI sigcleave swissprot:AVTA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AVTA_ECOLI ## Database ID URL or Descriptions # AltName ADPP_ECOLI ADP-ribose diphosphatase # AltName ADPP_ECOLI ADP-ribose phosphohydrolase # AltName ADPP_ECOLI Adenosine diphosphoribose pyrophosphatase # BRENDA 3.6.1.13 2026 # BioGrid 4263247 23 # CATALYTIC ACTIVITY ADP-D-ribose + H(2)O = AMP + D-ribose 5- phosphate. {ECO:0000269|PubMed 11323725}. # COFACTOR ADPP_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 11323725, ECO 0000269|PubMed 12135348}; Note=Binds 3 Mg(2+) ions per subunit. {ECO 0000269|PubMed 11323725, ECO 0000269|PubMed 12135348}; # ENZYME REGULATION ADPP_ECOLI Inhibited by phosphorylated compounds such as AMP, ADP, ATP, 3-phosphoglyceric acid and PPi. Not inhibited by orthophosphate. Activity is high in cells grown in low glucose concentrations and decreases dramatically as glucose concentration increases. # EcoGene EG12184 nudF # FUNCTION ADPP_ECOLI Acts on ADP-mannose and ADP-glucose as well as ADP- ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process. {ECO 0000269|PubMed 11416161}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0019144 ADP-sugar diphosphatase activity; IDA:EcoCyc. # GO_function GO:0047631 ADP-ribose diphosphatase activity; IDA:EcoCyc. # GO_process GO:0009408 response to heat; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # Gene3D 3.90.79.10 -; 1. # IntAct Q93K97 5 # InterPro IPR000086 NUDIX_hydrolase_dom # InterPro IPR004385 NDP_pyrophosphatase # InterPro IPR015797 NUDIX_hydrolase_dom-like # InterPro IPR020084 NUDIX_hydrolase_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # Organism ADPP_ECOLI Escherichia coli (strain K12) # PATRIC 32121478 VBIEscCol129921_3126 # PDB 1G0S X-ray; 1.90 A; A/B=1-209 # PDB 1G9Q X-ray; 2.30 A; A/B=1-209 # PDB 1GA7 X-ray; 2.71 A; A/B=1-209 # PDB 1KHZ X-ray; 2.04 A; A/B=1-209 # PDB 1VIQ X-ray; 2.40 A; A/B/C=2-209 # PIR H65090 H65090 # PROSITE PS00893 NUDIX_BOX # PROSITE PS51462 NUDIX # Pfam PF00293 NUDIX # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ADPP_ECOLI ADP-ribose pyrophosphatase # RefSeq NP_417506 NC_000913.3 # RefSeq WP_000917117 NZ_LN832404.1 # SIMILARITY Belongs to the Nudix hydrolase family. NudF subfamily. {ECO 0000305}. # SIMILARITY Contains 1 nudix hydrolase domain. {ECO:0000255|PROSITE-ProRule PRU00794}. # SUBUNIT ADPP_ECOLI Homodimer. {ECO 0000269|PubMed 11323725, ECO 0000269|PubMed 12135348}. # SUPFAM SSF55811 SSF55811 # TIGRFAMs TIGR00052 TIGR00052 # eggNOG ENOG41087AY Bacteria # eggNOG ENOG410ZYVG LUCA BLAST swissprot:ADPP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ADPP_ECOLI BioCyc ECOL316407:JW3002-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3002-MONOMER BioCyc EcoCyc:EG12633-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12633-MONOMER BioCyc MetaCyc:EG12633-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12633-MONOMER COG COG0494 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0494 DIP DIP-36214N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36214N DOI 10.1021/bi0259296 http://dx.doi.org/10.1021/bi0259296 DOI 10.1038/87647 http://dx.doi.org/10.1038/87647 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.131214098 http://dx.doi.org/10.1073/pnas.131214098 DOI 10.1074/jbc.271.41.25423 http://dx.doi.org/10.1074/jbc.271.41.25423 DOI 10.1074/jbc.274.45.32318 http://dx.doi.org/10.1074/jbc.274.45.32318 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.1.13 http://www.genome.jp/dbget-bin/www_bget?EC:3.6.1.13 EMBL AJ298136 http://www.ebi.ac.uk/ena/data/view/AJ298136 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D16557 http://www.ebi.ac.uk/ena/data/view/D16557 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 ENZYME 3.6.1.13 http://enzyme.expasy.org/EC/3.6.1.13 EcoGene EG12184 http://www.ecogene.org/geneInfo.php?eg_id=EG12184 EnsemblBacteria AAC76070 http://www.ensemblgenomes.org/id/AAC76070 EnsemblBacteria AAC76070 http://www.ensemblgenomes.org/id/AAC76070 EnsemblBacteria BAE77090 http://www.ensemblgenomes.org/id/BAE77090 EnsemblBacteria BAE77090 http://www.ensemblgenomes.org/id/BAE77090 EnsemblBacteria BAE77090 http://www.ensemblgenomes.org/id/BAE77090 EnsemblBacteria b3034 http://www.ensemblgenomes.org/id/b3034 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0019144 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019144 GO_function GO:0047631 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047631 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.90.79.10 http://www.cathdb.info/version/latest/superfamily/3.90.79.10 GeneID 947519 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947519 HOGENOM HOG000045857 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000045857&db=HOGENOM6 InParanoid Q93K97 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q93K97 IntAct Q93K97 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q93K97* IntEnz 3.6.1.13 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.1.13 InterPro IPR000086 http://www.ebi.ac.uk/interpro/entry/IPR000086 InterPro IPR004385 http://www.ebi.ac.uk/interpro/entry/IPR004385 InterPro IPR015797 http://www.ebi.ac.uk/interpro/entry/IPR015797 InterPro IPR020084 http://www.ebi.ac.uk/interpro/entry/IPR020084 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3002 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3002 KEGG_Gene eco:b3034 http://www.genome.jp/dbget-bin/www_bget?eco:b3034 KEGG_Orthology KO:K01515 http://www.genome.jp/dbget-bin/www_bget?KO:K01515 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Reaction rn:R01054 http://www.genome.jp/dbget-bin/www_bget?rn:R01054 OMA EQAYQWM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EQAYQWM PDB 1G0S http://www.ebi.ac.uk/pdbe-srv/view/entry/1G0S PDB 1G9Q http://www.ebi.ac.uk/pdbe-srv/view/entry/1G9Q PDB 1GA7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1GA7 PDB 1KHZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1KHZ PDB 1VIQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1VIQ PDBsum 1G0S http://www.ebi.ac.uk/pdbsum/1G0S PDBsum 1G9Q http://www.ebi.ac.uk/pdbsum/1G9Q PDBsum 1GA7 http://www.ebi.ac.uk/pdbsum/1GA7 PDBsum 1KHZ http://www.ebi.ac.uk/pdbsum/1KHZ PDBsum 1VIQ http://www.ebi.ac.uk/pdbsum/1VIQ PROSITE PS00893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00893 PROSITE PS51462 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51462 PSORT swissprot:ADPP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ADPP_ECOLI PSORT-B swissprot:ADPP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ADPP_ECOLI PSORT2 swissprot:ADPP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ADPP_ECOLI Pfam PF00293 http://pfam.xfam.org/family/PF00293 Phobius swissprot:ADPP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ADPP_ECOLI PhylomeDB Q93K97 http://phylomedb.org/?seqid=Q93K97 ProteinModelPortal Q93K97 http://www.proteinmodelportal.org/query/uniprot/Q93K97 PubMed 10542272 http://www.ncbi.nlm.nih.gov/pubmed/10542272 PubMed 11323725 http://www.ncbi.nlm.nih.gov/pubmed/11323725 PubMed 11416161 http://www.ncbi.nlm.nih.gov/pubmed/11416161 PubMed 12135348 http://www.ncbi.nlm.nih.gov/pubmed/12135348 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8810311 http://www.ncbi.nlm.nih.gov/pubmed/8810311 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417506 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417506 RefSeq WP_000917117 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000917117 SMR Q93K97 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q93K97 STRING 511145.b3034 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3034&targetmode=cogs STRING COG0494 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0494&targetmode=cogs SUPFAM SSF55811 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55811 TIGRFAMs TIGR00052 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00052 UniProtKB ADPP_ECOLI http://www.uniprot.org/uniprot/ADPP_ECOLI UniProtKB-AC Q93K97 http://www.uniprot.org/uniprot/Q93K97 charge swissprot:ADPP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ADPP_ECOLI eggNOG ENOG41087AY http://eggnogapi.embl.de/nog_data/html/tree/ENOG41087AY eggNOG ENOG410ZYVG http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZYVG epestfind swissprot:ADPP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ADPP_ECOLI garnier swissprot:ADPP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ADPP_ECOLI helixturnhelix swissprot:ADPP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ADPP_ECOLI hmoment swissprot:ADPP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ADPP_ECOLI iep swissprot:ADPP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ADPP_ECOLI inforesidue swissprot:ADPP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ADPP_ECOLI octanol swissprot:ADPP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ADPP_ECOLI pepcoil swissprot:ADPP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ADPP_ECOLI pepdigest swissprot:ADPP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ADPP_ECOLI pepinfo swissprot:ADPP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ADPP_ECOLI pepnet swissprot:ADPP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ADPP_ECOLI pepstats swissprot:ADPP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ADPP_ECOLI pepwheel swissprot:ADPP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ADPP_ECOLI pepwindow swissprot:ADPP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ADPP_ECOLI sigcleave swissprot:ADPP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ADPP_ECOLI ## Database ID URL or Descriptions # BioGrid 4260085 11 # CDD cd00118 LysM # DISRUPTION PHENOTYPE Simultaneous disruption of erfK, ybiS, ycfS and ynhG leads to loss of covalent anchoring of the major outer membrane lipoprotein (Lpp) to the peptidoglycan. Complementation with ycfS restores some of this anchoring. {ECO:0000269|PubMed 18456808}. # EcoGene EG13437 ycfS # FUNCTION YCFS_ECOLI Responsible, at least in part, for anchoring of the major outer membrane lipoprotein (Lpp, also known as the Braun lipoprotein) to the peptidoglycan via a meso-diaminopimelyl-L-Lys- bond on the terminal residue of Lpp. {ECO 0000269|PubMed 18456808}. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_function GO:0016755 transferase activity, transferring amino-acyl groups; IMP:EcoCyc. # GO_function GO:0016757 transferase activity, transferring glycosyl groups; IEA:UniProtKB-KW. # GO_function GO:0016807 cysteine-type carboxypeptidase activity; IMP:EcoCyc. # GO_function GO:0071972 peptidoglycan L,D-transpeptidase activity; IMP:EcoCyc. # GO_process GO:0008360 regulation of cell shape; IEA:UniProtKB-KW. # GO_process GO:0018104 peptidoglycan-protein cross-linking; IMP:EcoCyc. # GO_process GO:0043164 Gram-negative-bacterium-type cell wall biogenesis; IMP:EcoCyc. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 3.10.350.10 -; 1. # IntAct P75954 2 # InterPro IPR005490 LD_TPept_cat_dom # InterPro IPR018392 LysM_dom # KEGG_Brite ko01002 Peptidases # Organism YCFS_ECOLI Escherichia coli (strain K12) # PATHWAY YCFS_ECOLI Cell wall biogenesis; peptidoglycan biosynthesis. # PATRIC 32117469 VBIEscCol129921_1157 # PIR F64855 F64855 # PROSITE PS51782 LYSM # Pfam PF01476 LysM # Pfam PF03734 YkuD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCFS_ECOLI Probable L,D-transpeptidase YcfS # RefSeq NP_415631 NC_000913.3 # SIMILARITY Belongs to the YkuD family. {ECO 0000305}. # SIMILARITY Contains 1 LysM domain. {ECO:0000255|PROSITE- ProRule PRU01118}. # SMART SM00257 LysM # SUBCELLULAR LOCATION YCFS_ECOLI Periplasm {ECO 0000305}. # SUBUNIT Interacts with DsbG. {ECO:0000269|PubMed 19965429}. # eggNOG COG1376 LUCA # eggNOG ENOG4107N1Q Bacteria BLAST swissprot:YCFS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCFS_ECOLI BioCyc ECOL316407:JW5820-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5820-MONOMER BioCyc EcoCyc:G6571-MONOMER http://biocyc.org/getid?id=EcoCyc:G6571-MONOMER BioCyc MetaCyc:G6571-MONOMER http://biocyc.org/getid?id=MetaCyc:G6571-MONOMER COG COG1376 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1376 DIP DIP-11546N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11546N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1179557 http://dx.doi.org/10.1126/science.1179557 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00025-08 http://dx.doi.org/10.1128/JB.00025-08 EC_number EC:2.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:2.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.-.-.- http://enzyme.expasy.org/EC/2.-.-.- EchoBASE EB3211 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3211 EcoGene EG13437 http://www.ecogene.org/geneInfo.php?eg_id=EG13437 EnsemblBacteria AAC74197 http://www.ensemblgenomes.org/id/AAC74197 EnsemblBacteria AAC74197 http://www.ensemblgenomes.org/id/AAC74197 EnsemblBacteria BAA35928 http://www.ensemblgenomes.org/id/BAA35928 EnsemblBacteria BAA35928 http://www.ensemblgenomes.org/id/BAA35928 EnsemblBacteria BAA35928 http://www.ensemblgenomes.org/id/BAA35928 EnsemblBacteria b1113 http://www.ensemblgenomes.org/id/b1113 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0016755 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016755 GO_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GO_function GO:0016807 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016807 GO_function GO:0071972 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071972 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0018104 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018104 GO_process GO:0043164 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043164 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 3.10.350.10 http://www.cathdb.info/version/latest/superfamily/3.10.350.10 GeneID 945666 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945666 HOGENOM HOG000274378 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000274378&db=HOGENOM6 InParanoid P75954 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75954 IntAct P75954 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75954* IntEnz 2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2 InterPro IPR005490 http://www.ebi.ac.uk/interpro/entry/IPR005490 InterPro IPR018392 http://www.ebi.ac.uk/interpro/entry/IPR018392 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW5820 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5820 KEGG_Gene eco:b1113 http://www.genome.jp/dbget-bin/www_bget?eco:b1113 KEGG_Orthology KO:K16291 http://www.genome.jp/dbget-bin/www_bget?KO:K16291 MINT MINT-1263012 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1263012 OMA TDPYLPK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TDPYLPK PROSITE PS51782 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51782 PSORT swissprot:YCFS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCFS_ECOLI PSORT-B swissprot:YCFS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCFS_ECOLI PSORT2 swissprot:YCFS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCFS_ECOLI Pfam PF01476 http://pfam.xfam.org/family/PF01476 Pfam PF03734 http://pfam.xfam.org/family/PF03734 Phobius swissprot:YCFS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCFS_ECOLI PhylomeDB P75954 http://phylomedb.org/?seqid=P75954 ProteinModelPortal P75954 http://www.proteinmodelportal.org/query/uniprot/P75954 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18456808 http://www.ncbi.nlm.nih.gov/pubmed/18456808 PubMed 19965429 http://www.ncbi.nlm.nih.gov/pubmed/19965429 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415631 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415631 SMART SM00257 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00257 SMR P75954 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75954 STRING 511145.b1113 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1113&targetmode=cogs STRING COG1376 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1376&targetmode=cogs UniProtKB YCFS_ECOLI http://www.uniprot.org/uniprot/YCFS_ECOLI UniProtKB-AC P75954 http://www.uniprot.org/uniprot/P75954 charge swissprot:YCFS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCFS_ECOLI eggNOG COG1376 http://eggnogapi.embl.de/nog_data/html/tree/COG1376 eggNOG ENOG4107N1Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107N1Q epestfind swissprot:YCFS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCFS_ECOLI garnier swissprot:YCFS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCFS_ECOLI helixturnhelix swissprot:YCFS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCFS_ECOLI hmoment swissprot:YCFS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCFS_ECOLI iep swissprot:YCFS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCFS_ECOLI inforesidue swissprot:YCFS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCFS_ECOLI octanol swissprot:YCFS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCFS_ECOLI pepcoil swissprot:YCFS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCFS_ECOLI pepdigest swissprot:YCFS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCFS_ECOLI pepinfo swissprot:YCFS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCFS_ECOLI pepnet swissprot:YCFS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCFS_ECOLI pepstats swissprot:YCFS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCFS_ECOLI pepwheel swissprot:YCFS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCFS_ECOLI pepwindow swissprot:YCFS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCFS_ECOLI sigcleave swissprot:YCFS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCFS_ECOLI ## Database ID URL or Descriptions # EcoGene EG40007 insG # FUNCTION INSG_ECOLI Involved in the transposition of the insertion sequence IS4. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # InterPro IPR002559 Transposase_11 # InterPro IPR012337 RNaseH-like_dom # InterPro IPR024473 Transposases_IS4_N # Organism INSG_ECOLI Escherichia coli (strain K12) # PATRIC 32124129 VBIEscCol129921_4408 # PIR A04463 IEEC41 # Pfam PF01609 DDE_Tnp_1 # Pfam PF13006 Nterm_IS4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSG_ECOLI Transposase InsG for insertion sequence element IS4 # RefSeq NP_418698 NC_000913.3 # RefSeq WP_000547191 NZ_LN832404.1 # SIMILARITY Belongs to the transposase 11 family. {ECO 0000305}. # SUPFAM SSF53098 SSF53098 # eggNOG COG3385 LUCA # eggNOG ENOG4105VNT Bacteria BLAST swissprot:INSG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSG_ECOLI BioCyc ECOL316407:JW5767-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5767-MONOMER BioCyc EcoCyc:G7900-MONOMER http://biocyc.org/getid?id=EcoCyc:G7900-MONOMER COG COG3385 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3385 DOI 10.1007/BF00268423 http://dx.doi.org/10.1007/BF00268423 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01733 http://www.ebi.ac.uk/ena/data/view/J01733 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB4735 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4735 EcoGene EG40007 http://www.ecogene.org/geneInfo.php?eg_id=EG40007 EnsemblBacteria AAC77234 http://www.ensemblgenomes.org/id/AAC77234 EnsemblBacteria AAC77234 http://www.ensemblgenomes.org/id/AAC77234 EnsemblBacteria BAE78272 http://www.ensemblgenomes.org/id/BAE78272 EnsemblBacteria BAE78272 http://www.ensemblgenomes.org/id/BAE78272 EnsemblBacteria BAE78272 http://www.ensemblgenomes.org/id/BAE78272 EnsemblBacteria b4278 http://www.ensemblgenomes.org/id/b4278 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GeneID 948805 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948805 HOGENOM HOG000119822 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000119822&db=HOGENOM6 InParanoid P03835 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P03835 InterPro IPR002559 http://www.ebi.ac.uk/interpro/entry/IPR002559 InterPro IPR012337 http://www.ebi.ac.uk/interpro/entry/IPR012337 InterPro IPR024473 http://www.ebi.ac.uk/interpro/entry/IPR024473 KEGG_Gene ecj:JW5767 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5767 KEGG_Gene eco:b4278 http://www.genome.jp/dbget-bin/www_bget?eco:b4278 KEGG_Orthology KO:K07495 http://www.genome.jp/dbget-bin/www_bget?KO:K07495 OMA TVFDKGF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TVFDKGF PSORT swissprot:INSG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSG_ECOLI PSORT-B swissprot:INSG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSG_ECOLI PSORT2 swissprot:INSG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSG_ECOLI Pfam PF01609 http://pfam.xfam.org/family/PF01609 Pfam PF13006 http://pfam.xfam.org/family/PF13006 Phobius swissprot:INSG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSG_ECOLI PhylomeDB P03835 http://phylomedb.org/?seqid=P03835 ProteinModelPortal P03835 http://www.proteinmodelportal.org/query/uniprot/P03835 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6268937 http://www.ncbi.nlm.nih.gov/pubmed/6268937 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418698 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418698 RefSeq WP_000547191 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000547191 STRING 511145.b4278 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4278&targetmode=cogs STRING COG3385 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3385&targetmode=cogs SUPFAM SSF53098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098 UniProtKB INSG_ECOLI http://www.uniprot.org/uniprot/INSG_ECOLI UniProtKB-AC P03835 http://www.uniprot.org/uniprot/P03835 charge swissprot:INSG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSG_ECOLI eggNOG COG3385 http://eggnogapi.embl.de/nog_data/html/tree/COG3385 eggNOG ENOG4105VNT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VNT epestfind swissprot:INSG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSG_ECOLI garnier swissprot:INSG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSG_ECOLI helixturnhelix swissprot:INSG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSG_ECOLI hmoment swissprot:INSG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSG_ECOLI iep swissprot:INSG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSG_ECOLI inforesidue swissprot:INSG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSG_ECOLI octanol swissprot:INSG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSG_ECOLI pepcoil swissprot:INSG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSG_ECOLI pepdigest swissprot:INSG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSG_ECOLI pepinfo swissprot:INSG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSG_ECOLI pepnet swissprot:INSG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSG_ECOLI pepstats swissprot:INSG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSG_ECOLI pepwheel swissprot:INSG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSG_ECOLI pepwindow swissprot:INSG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSG_ECOLI sigcleave swissprot:INSG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSG_ECOLI ## Database ID URL or Descriptions # BioGrid 4261164 9 # EcoGene EG14070 rcnR # FUNCTION RCNR_ECOLI Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter. {ECO 0000269|PubMed 16956381, ECO 0000269|PubMed 17120142}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0046872 metal ion binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # IntAct P64530 8 # InterPro IPR003735 Metal_Tscrpt_repr # Organism RCNR_ECOLI Escherichia coli (strain K12) # PATRIC 32119543 VBIEscCol129921_2182 # PIR H64977 H64977 # Pfam PF02583 Trns_repr_metal # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RCNR_ECOLI Transcriptional repressor RcnR # RefSeq NP_416608 NC_000913.3 # RefSeq WP_000019944 NZ_LN832404.1 # SIMILARITY Belongs to the FrmR/RcnR family. {ECO 0000305}. # SUBCELLULAR LOCATION RCNR_ECOLI Cytoplasm {ECO 0000305}. # eggNOG COG1937 LUCA # eggNOG ENOG41090EM Bacteria BLAST swissprot:RCNR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RCNR_ECOLI BioCyc ECOL316407:JW2092-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2092-MONOMER BioCyc EcoCyc:G7137-MONOMER http://biocyc.org/getid?id=EcoCyc:G7137-MONOMER DOI 10.1007/s10534-006-9039-6 http://dx.doi.org/10.1007/s10534-006-9039-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2006.05369.x http://dx.doi.org/10.1111/j.1365-2958.2006.05369.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3823 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3823 EcoGene EG14070 http://www.ecogene.org/geneInfo.php?eg_id=EG14070 EnsemblBacteria AAC75166 http://www.ensemblgenomes.org/id/AAC75166 EnsemblBacteria AAC75166 http://www.ensemblgenomes.org/id/AAC75166 EnsemblBacteria BAE76586 http://www.ensemblgenomes.org/id/BAE76586 EnsemblBacteria BAE76586 http://www.ensemblgenomes.org/id/BAE76586 EnsemblBacteria BAE76586 http://www.ensemblgenomes.org/id/BAE76586 EnsemblBacteria b2105 http://www.ensemblgenomes.org/id/b2105 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 947114 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947114 HOGENOM HOG000023914 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000023914&db=HOGENOM6 InParanoid P64530 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P64530 IntAct P64530 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P64530* InterPro IPR003735 http://www.ebi.ac.uk/interpro/entry/IPR003735 KEGG_Gene ecj:JW2092 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2092 KEGG_Gene eco:b2105 http://www.genome.jp/dbget-bin/www_bget?eco:b2105 OMA HLTECIA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HLTECIA PSORT swissprot:RCNR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RCNR_ECOLI PSORT-B swissprot:RCNR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RCNR_ECOLI PSORT2 swissprot:RCNR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RCNR_ECOLI Pfam PF02583 http://pfam.xfam.org/family/PF02583 Phobius swissprot:RCNR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RCNR_ECOLI PhylomeDB P64530 http://phylomedb.org/?seqid=P64530 ProteinModelPortal P64530 http://www.proteinmodelportal.org/query/uniprot/P64530 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16956381 http://www.ncbi.nlm.nih.gov/pubmed/16956381 PubMed 17120142 http://www.ncbi.nlm.nih.gov/pubmed/17120142 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416608 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416608 RefSeq WP_000019944 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000019944 STRING 511145.b2105 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2105&targetmode=cogs UniProtKB RCNR_ECOLI http://www.uniprot.org/uniprot/RCNR_ECOLI UniProtKB-AC P64530 http://www.uniprot.org/uniprot/P64530 charge swissprot:RCNR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RCNR_ECOLI eggNOG COG1937 http://eggnogapi.embl.de/nog_data/html/tree/COG1937 eggNOG ENOG41090EM http://eggnogapi.embl.de/nog_data/html/tree/ENOG41090EM epestfind swissprot:RCNR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RCNR_ECOLI garnier swissprot:RCNR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RCNR_ECOLI helixturnhelix swissprot:RCNR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RCNR_ECOLI hmoment swissprot:RCNR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RCNR_ECOLI iep swissprot:RCNR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RCNR_ECOLI inforesidue swissprot:RCNR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RCNR_ECOLI octanol swissprot:RCNR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RCNR_ECOLI pepcoil swissprot:RCNR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RCNR_ECOLI pepdigest swissprot:RCNR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RCNR_ECOLI pepinfo swissprot:RCNR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RCNR_ECOLI pepnet swissprot:RCNR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RCNR_ECOLI pepstats swissprot:RCNR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RCNR_ECOLI pepwheel swissprot:RCNR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RCNR_ECOLI pepwindow swissprot:RCNR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RCNR_ECOLI sigcleave swissprot:RCNR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RCNR_ECOLI ## Database ID URL or Descriptions # BioGrid 4259199 13 # COFACTOR HYFA_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000250}; Note=Binds 4 [4Fe-4S] clusters. {ECO 0000250}; # EcoGene EG11150 hyfA # FUNCTION HYFA_ECOLI Probable electron transfer protein for hydrogenase 4. # GO_function GO:0016491 oxidoreductase activity; IEA:UniProtKB-KW. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # IntAct P23481 3 # InterPro IPR017896 4Fe4S_Fe-S-bd # InterPro IPR017900 4Fe4S_Fe_S_CS # KEGG_Brite ko01000 Enzymes # Organism HYFA_ECOLI Escherichia coli (strain K12) # PATRIC 32120349 VBIEscCol129921_2577 # PIR H65023 H65023 # PROSITE PS00198 4FE4S_FER_1 # PROSITE PS51379 4FE4S_FER_2; 4 # Pfam PF00037 Fer4 # Pfam PF12798 Fer4_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HYFA_ECOLI Hydrogenase-4 component A # RefSeq NP_416976 NC_000913.3 # RefSeq WP_001336048 NZ_LN832404.1 # SIMILARITY Contains 4 4Fe-4S ferredoxin-type domains. {ECO:0000255|PROSITE-ProRule PRU00711}. # TCDB 3.D.1.9 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family # eggNOG COG1142 LUCA # eggNOG ENOG4108MFN Bacteria BLAST swissprot:HYFA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HYFA_ECOLI BioCyc ECOL316407:JW2466-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2466-MONOMER BioCyc EcoCyc:MONOMER0-152 http://biocyc.org/getid?id=EcoCyc:MONOMER0-152 COG COG1142 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1142 DIP DIP-9983N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9983N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1099/00221287-137-2-361 http://dx.doi.org/10.1099/00221287-137-2-361 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M63654 http://www.ebi.ac.uk/ena/data/view/M63654 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- EchoBASE EB1139 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1139 EcoGene EG11150 http://www.ecogene.org/geneInfo.php?eg_id=EG11150 EnsemblBacteria AAC75534 http://www.ensemblgenomes.org/id/AAC75534 EnsemblBacteria AAC75534 http://www.ensemblgenomes.org/id/AAC75534 EnsemblBacteria BAA16359 http://www.ensemblgenomes.org/id/BAA16359 EnsemblBacteria BAA16359 http://www.ensemblgenomes.org/id/BAA16359 EnsemblBacteria BAA16359 http://www.ensemblgenomes.org/id/BAA16359 EnsemblBacteria b2481 http://www.ensemblgenomes.org/id/b2481 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GeneID 946959 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946959 HOGENOM HOG000163385 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000163385&db=HOGENOM6 InParanoid P23481 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23481 IntAct P23481 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P23481* IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR017896 http://www.ebi.ac.uk/interpro/entry/IPR017896 InterPro IPR017900 http://www.ebi.ac.uk/interpro/entry/IPR017900 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2466 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2466 KEGG_Gene eco:b2481 http://www.genome.jp/dbget-bin/www_bget?eco:b2481 KEGG_Orthology KO:K12136 http://www.genome.jp/dbget-bin/www_bget?KO:K12136 OMA KLCGLVC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KLCGLVC PROSITE PS00198 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00198 PROSITE PS51379 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51379 PSORT swissprot:HYFA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HYFA_ECOLI PSORT-B swissprot:HYFA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HYFA_ECOLI PSORT2 swissprot:HYFA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HYFA_ECOLI Pfam PF00037 http://pfam.xfam.org/family/PF00037 Pfam PF12798 http://pfam.xfam.org/family/PF12798 Phobius swissprot:HYFA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HYFA_ECOLI PhylomeDB P23481 http://phylomedb.org/?seqid=P23481 ProteinModelPortal P23481 http://www.proteinmodelportal.org/query/uniprot/P23481 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2016588 http://www.ncbi.nlm.nih.gov/pubmed/2016588 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416976 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416976 RefSeq WP_001336048 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001336048 STRING 511145.b2481 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2481&targetmode=cogs STRING COG1142 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1142&targetmode=cogs TCDB 3.D.1.9 http://www.tcdb.org/search/result.php?tc=3.D.1.9 UniProtKB HYFA_ECOLI http://www.uniprot.org/uniprot/HYFA_ECOLI UniProtKB-AC P23481 http://www.uniprot.org/uniprot/P23481 charge swissprot:HYFA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HYFA_ECOLI eggNOG COG1142 http://eggnogapi.embl.de/nog_data/html/tree/COG1142 eggNOG ENOG4108MFN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MFN epestfind swissprot:HYFA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HYFA_ECOLI garnier swissprot:HYFA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HYFA_ECOLI helixturnhelix swissprot:HYFA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HYFA_ECOLI hmoment swissprot:HYFA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HYFA_ECOLI iep swissprot:HYFA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HYFA_ECOLI inforesidue swissprot:HYFA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HYFA_ECOLI octanol swissprot:HYFA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HYFA_ECOLI pepcoil swissprot:HYFA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HYFA_ECOLI pepdigest swissprot:HYFA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HYFA_ECOLI pepinfo swissprot:HYFA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HYFA_ECOLI pepnet swissprot:HYFA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HYFA_ECOLI pepstats swissprot:HYFA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HYFA_ECOLI pepwheel swissprot:HYFA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HYFA_ECOLI pepwindow swissprot:HYFA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HYFA_ECOLI sigcleave swissprot:HYFA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HYFA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261615 6 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG12610 yabP # IntAct P39220 4 # Organism YABP_ECOLI Escherichia coli (strain K12) # PATRIC 48659292 VBIEscCol107702_0052 # PIR H64726 H64726 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YABP_ECOLI Putative uncharacterized protein YabP BLAST swissprot:YABP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YABP_ECOLI BioCyc ECOL316407:JW0055-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0055-MONOMER BioCyc EcoCyc:EG12610-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12610-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2494 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2494 EcoGene EG12610 http://www.ecogene.org/geneInfo.php?eg_id=EG12610 EnsemblBacteria BAB96624 http://www.ensemblgenomes.org/id/BAB96624 EnsemblBacteria BAB96624 http://www.ensemblgenomes.org/id/BAB96624 EnsemblBacteria BAB96624 http://www.ensemblgenomes.org/id/BAB96624 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv HOGENOM HOG000078289 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000078289&db=HOGENOM6 IntAct P39220 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39220* KEGG_Gene ecj:JW0055 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0055 OMA GWNANLD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GWNANLD PSORT swissprot:YABP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YABP_ECOLI PSORT-B swissprot:YABP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YABP_ECOLI PSORT2 swissprot:YABP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YABP_ECOLI Phobius swissprot:YABP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YABP_ECOLI ProteinModelPortal P39220 http://www.proteinmodelportal.org/query/uniprot/P39220 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SMR P39220 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39220 STRING 316407.85674305 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85674305&targetmode=cogs UniProtKB YABP_ECOLI http://www.uniprot.org/uniprot/YABP_ECOLI UniProtKB-AC P39220 http://www.uniprot.org/uniprot/P39220 charge swissprot:YABP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YABP_ECOLI epestfind swissprot:YABP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YABP_ECOLI garnier swissprot:YABP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YABP_ECOLI helixturnhelix swissprot:YABP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YABP_ECOLI hmoment swissprot:YABP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YABP_ECOLI iep swissprot:YABP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YABP_ECOLI inforesidue swissprot:YABP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YABP_ECOLI octanol swissprot:YABP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YABP_ECOLI pepcoil swissprot:YABP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YABP_ECOLI pepdigest swissprot:YABP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YABP_ECOLI pepinfo swissprot:YABP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YABP_ECOLI pepnet swissprot:YABP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YABP_ECOLI pepstats swissprot:YABP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YABP_ECOLI pepwheel swissprot:YABP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YABP_ECOLI pepwindow swissprot:YABP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YABP_ECOLI sigcleave swissprot:YABP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YABP_ECOLI ## Database ID URL or Descriptions # AltName Exonuclease V subunit RecD {ECO:0000255|HAMAP-Rule MF_01487} # AltName Helicase/nuclease RecBCD subunit RecD {ECO:0000255|HAMAP-Rule MF_01487} # AltName RECD_ECOLI Exodeoxyribonuclease V 67 kDa polypeptide # AltName RECD_ECOLI Exodeoxyribonuclease V alpha chain # BRENDA 3.1.11 2026 # BioGrid 4260684 132 # CATALYTIC ACTIVITY Exonucleolytic cleavage (in the presence of ATP) in either 5'- to 3'- or 3'- to 5'-direction to yield 5'- phosphooligonucleotides. {ECO:0000255|HAMAP-Rule MF_01487}. # DISRUPTION PHENOTYPE RECD_ECOLI Loss of RecBCD enzyme exonuclease activity, no effect on recombination proficiency or resistance to DNA- damaging agents. {ECO 0000269|PubMed 10840065, ECO 0000269|PubMed 3526335}. # DOMAIN RECD_ECOLI The holoenzyme may undergo conformational shifts upon DNA binding the nuclease domain of RecB may swing away from the DNA exit tunnel in RecC. When Chi DNA binds to the RecC tunnel the nuclease domain may then swing back to its original position (that seen in crystal structures), allowing it to nick the DNA 3' of the Chi site and then rotate to load RecA. At high Mg(2+) the nuclease domain may swing back more frequently, explaining differences seen in assays performed at high Mg(2+). {ECO 0000269|PubMed 25073102}. # ENZYME REGULATION RECD_ECOLI In isolated subunit ATPase and 5'-3' helicase activity are inhibited by non-hydrolyzable ATP analogs and EDTA (PubMed 12815438). After reacting with DNA bearing a Chi site the holoenzyme is disassembled and loses exonuclease activity, DNA unwinding and Chi-directed DNA cleavage; RecB remains complexed with ssDNA, which may prevent holoenzyme reassembly (PubMed 10197988). High levels of Mg(2+) (13 mM MgCl(2+)) or incubation with DNase allow holoenyzme reassembly, suggesting it is DNA bound to RecB that prevents reassembly (PubMed 10197988). {ECO 0000269|PubMed 10197988, ECO 0000269|PubMed 12815438, ECO 0000269|PubMed 1535156}. # EcoGene EG10826 recD # FUNCTION RECD_ECOLI A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a rapid (>1 kb/second) and highly processive (>30 kb) ATP-dependent bidirectional helicase. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator, 5'-GCTGGTGG-3') sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to Chi site, by nicking one strand or switching the strand degraded (depending on the reaction conditions). The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang which facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. In the holoenzyme this subunit contributes ssDNA-dependent ATPase and fast 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD. {ECO 0000269|PubMed 10197988, ECO 0000269|PubMed 10840065, ECO 0000269|PubMed 12815437, ECO 0000269|PubMed 12815438, ECO 0000269|PubMed 1535156, ECO 0000269|PubMed 16041061, ECO 0000269|PubMed 1618858, ECO 0000269|PubMed 18079176, ECO 0000269|PubMed 23851395, ECO 0000269|PubMed 7608206, ECO 0000269|PubMed 9192629, ECO 0000269|PubMed 9230304, ECO 0000269|PubMed 9448271, ECO 0000269|PubMed 9790841}. # GO_component GO:0009338 exodeoxyribonuclease V complex; IDA:EcoliWiki. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0004003 ATP-dependent DNA helicase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0004386 helicase activity; IDA:EcoCyc. # GO_function GO:0004519 endonuclease activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IDA:EcoliWiki. # GO_function GO:0008854 exodeoxyribonuclease V activity; IDA:EcoCyc. # GO_function GO:0043142 single-stranded DNA-dependent ATPase activity; IDA:EcoCyc. # GO_process GO:0000724 double-strand break repair via homologous recombination; IEA:UniProtKB-HAMAP. # GO_process GO:0006302 double-strand break repair; IDA:EcoCyc. # GO_process GO:0006310 DNA recombination; IDA:EcoliWiki. # GO_process GO:0006974 cellular response to DNA damage stimulus; IDA:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004386 helicase activity # GOslim_function GO:0004518 nuclease activity # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # Gene3D 3.40.50.300 -; 3. # HAMAP MF_01487 RecD # IntAct P04993 13 # InterPro IPR003593 AAA+_ATPase # InterPro IPR006344 RecD # InterPro IPR027417 P-loop_NTPase # InterPro IPR027785 UvrD-like_helicase_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko03440 Homologous recombination # Organism RECD_ECOLI Escherichia coli (strain K12) # PATRIC 32121056 VBIEscCol129921_2917 # PDB 1W36 X-ray; 3.10 A; D/G=1-608 # PDB 3K70 X-ray; 3.59 A; D/G=1-608 # PDB 5LD2 EM; 3.83 A; D=2-608 # PIR D65064 NCECXF # Pfam PF13538 UvrD_C_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RecBCD enzyme subunit RecD {ECO:0000255|HAMAP-Rule MF_01487} # RefSeq NP_417296 NC_000913.3 # RefSeq WP_000775955 NZ_LN832404.1 # SIMILARITY Belongs to the RecD family. {ECO:0000255|HAMAP- Rule MF_01487}. # SMART SM00382 AAA # SUBUNIT RECD_ECOLI Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding. {ECO 0000255|HAMAP-Rule MF_01487, ECO 0000269|PubMed 15538360, ECO 0000269|PubMed 1618858, ECO 0000269|PubMed 18668125, ECO 0000269|PubMed 3526335}. # SUPFAM SSF52540 SSF52540; 3 # TIGRFAMs TIGR01447 recD # eggNOG COG0507 LUCA # eggNOG ENOG4107QYX Bacteria BLAST swissprot:RECD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RECD_ECOLI BioCyc ECOL316407:JW2787-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2787-MONOMER BioCyc EcoCyc:EG10826-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10826-MONOMER BioCyc MetaCyc:EG10826-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10826-MONOMER COG COG0507 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0507 DIP DIP-10651N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10651N DOI 10.1006/jmbi.1998.2127 http://dx.doi.org/10.1006/jmbi.1998.2127 DOI 10.1016/S0092-8674(00)80315-3 http://dx.doi.org/10.1016/S0092-8674(00)80315-3 DOI 10.1016/j.jmb.2014.07.017 http://dx.doi.org/10.1016/j.jmb.2014.07.017 DOI 10.1038/emboj.2008.144 http://dx.doi.org/10.1038/emboj.2008.144 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature01673 http://dx.doi.org/10.1038/nature01673 DOI 10.1038/nature01674 http://dx.doi.org/10.1038/nature01674 DOI 10.1038/nature02988 http://dx.doi.org/10.1038/nature02988 DOI 10.1038/nature12333 http://dx.doi.org/10.1038/nature12333 DOI 10.1073/pnas.130192397 http://dx.doi.org/10.1073/pnas.130192397 DOI 10.1073/pnas.83.15.5558 http://dx.doi.org/10.1073/pnas.83.15.5558 DOI 10.1073/pnas.89.12.5226 http://dx.doi.org/10.1073/pnas.89.12.5226 DOI 10.1073/pnas.94.13.6706 http://dx.doi.org/10.1073/pnas.94.13.6706 DOI 10.1073/pnas.95.3.981 http://dx.doi.org/10.1073/pnas.95.3.981 DOI 10.1074/jbc.270.27.16360 http://dx.doi.org/10.1074/jbc.270.27.16360 DOI 10.1074/jbc.M505520200 http://dx.doi.org/10.1074/jbc.M505520200 DOI 10.1093/nar/14.21.8573 http://dx.doi.org/10.1093/nar/14.21.8573 DOI 10.1093/nar/14.21.8583 http://dx.doi.org/10.1093/nar/14.21.8583 DOI 10.1101/gad.13.7.890 http://dx.doi.org/10.1101/gad.13.7.890 DOI 10.1101/gad.1605807 http://dx.doi.org/10.1101/gad.1605807 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/MMBR.00020-08 http://dx.doi.org/10.1128/MMBR.00020-08 DOI 10.1128/MMBR.05026-11 http://dx.doi.org/10.1128/MMBR.05026-11 EC_number EC:3.1.11.5 {ECO:0000255|HAMAP-Rule:MF_01487} http://www.genome.jp/dbget-bin/www_bget?EC:3.1.11.5 {ECO:0000255|HAMAP-Rule:MF_01487} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 EMBL X04581 http://www.ebi.ac.uk/ena/data/view/X04581 EMBL X04582 http://www.ebi.ac.uk/ena/data/view/X04582 ENZYME 3.1.11.5 {ECO:0000255|HAMAP-Rule:MF_01487} http://enzyme.expasy.org/EC/3.1.11.5 {ECO:0000255|HAMAP-Rule:MF_01487} EchoBASE EB0819 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0819 EcoGene EG10826 http://www.ecogene.org/geneInfo.php?eg_id=EG10826 EnsemblBacteria AAC75858 http://www.ensemblgenomes.org/id/AAC75858 EnsemblBacteria AAC75858 http://www.ensemblgenomes.org/id/AAC75858 EnsemblBacteria BAE76888 http://www.ensemblgenomes.org/id/BAE76888 EnsemblBacteria BAE76888 http://www.ensemblgenomes.org/id/BAE76888 EnsemblBacteria BAE76888 http://www.ensemblgenomes.org/id/BAE76888 EnsemblBacteria b2819 http://www.ensemblgenomes.org/id/b2819 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009338 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009338 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004003 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004003 GO_function GO:0004386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004386 GO_function GO:0004519 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004519 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008854 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008854 GO_function GO:0043142 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043142 GO_process GO:0000724 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000724 GO_process GO:0006302 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006302 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004386 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947287 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947287 HAMAP MF_01487 http://hamap.expasy.org/unirule/MF_01487 HOGENOM HOG000258341 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000258341&db=HOGENOM6 InParanoid P04993 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P04993 IntAct P04993 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P04993* IntEnz 3.1.11.5 {ECO:0000255|HAMAP-Rule:MF_01487} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.11.5 {ECO:0000255|HAMAP-Rule:MF_01487} InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR006344 http://www.ebi.ac.uk/interpro/entry/IPR006344 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR027785 http://www.ebi.ac.uk/interpro/entry/IPR027785 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW2787 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2787 KEGG_Gene eco:b2819 http://www.genome.jp/dbget-bin/www_bget?eco:b2819 KEGG_Orthology KO:K03581 http://www.genome.jp/dbget-bin/www_bget?KO:K03581 KEGG_Pathway ko03440 http://www.genome.jp/kegg-bin/show_pathway?ko03440 MINT MINT-1224412 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1224412 OMA NRERYLP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NRERYLP PDB 1W36 http://www.ebi.ac.uk/pdbe-srv/view/entry/1W36 PDB 3K70 http://www.ebi.ac.uk/pdbe-srv/view/entry/3K70 PDB 5LD2 http://www.ebi.ac.uk/pdbe-srv/view/entry/5LD2 PDBsum 1W36 http://www.ebi.ac.uk/pdbsum/1W36 PDBsum 3K70 http://www.ebi.ac.uk/pdbsum/3K70 PDBsum 5LD2 http://www.ebi.ac.uk/pdbsum/5LD2 PSORT swissprot:RECD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RECD_ECOLI PSORT-B swissprot:RECD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RECD_ECOLI PSORT2 swissprot:RECD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RECD_ECOLI Pfam PF13538 http://pfam.xfam.org/family/PF13538 Phobius swissprot:RECD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RECD_ECOLI PhylomeDB P04993 http://phylomedb.org/?seqid=P04993 ProteinModelPortal P04993 http://www.proteinmodelportal.org/query/uniprot/P04993 PubMed 10197988 http://www.ncbi.nlm.nih.gov/pubmed/10197988 PubMed 10840065 http://www.ncbi.nlm.nih.gov/pubmed/10840065 PubMed 12815437 http://www.ncbi.nlm.nih.gov/pubmed/12815437 PubMed 12815438 http://www.ncbi.nlm.nih.gov/pubmed/12815438 PubMed 1535156 http://www.ncbi.nlm.nih.gov/pubmed/1535156 PubMed 15538360 http://www.ncbi.nlm.nih.gov/pubmed/15538360 PubMed 16041061 http://www.ncbi.nlm.nih.gov/pubmed/16041061 PubMed 1618858 http://www.ncbi.nlm.nih.gov/pubmed/1618858 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18079176 http://www.ncbi.nlm.nih.gov/pubmed/18079176 PubMed 18668125 http://www.ncbi.nlm.nih.gov/pubmed/18668125 PubMed 19052323 http://www.ncbi.nlm.nih.gov/pubmed/19052323 PubMed 22688812 http://www.ncbi.nlm.nih.gov/pubmed/22688812 PubMed 23851395 http://www.ncbi.nlm.nih.gov/pubmed/23851395 PubMed 25073102 http://www.ncbi.nlm.nih.gov/pubmed/25073102 PubMed 3526335 http://www.ncbi.nlm.nih.gov/pubmed/3526335 PubMed 3537960 http://www.ncbi.nlm.nih.gov/pubmed/3537960 PubMed 3537961 http://www.ncbi.nlm.nih.gov/pubmed/3537961 PubMed 7608206 http://www.ncbi.nlm.nih.gov/pubmed/7608206 PubMed 9192629 http://www.ncbi.nlm.nih.gov/pubmed/9192629 PubMed 9230304 http://www.ncbi.nlm.nih.gov/pubmed/9230304 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9448271 http://www.ncbi.nlm.nih.gov/pubmed/9448271 PubMed 9790841 http://www.ncbi.nlm.nih.gov/pubmed/9790841 RefSeq NP_417296 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417296 RefSeq WP_000775955 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000775955 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P04993 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P04993 STRING 511145.b2819 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2819&targetmode=cogs STRING COG0507 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0507&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR01447 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01447 UniProtKB RECD_ECOLI http://www.uniprot.org/uniprot/RECD_ECOLI UniProtKB-AC P04993 http://www.uniprot.org/uniprot/P04993 charge swissprot:RECD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RECD_ECOLI eggNOG COG0507 http://eggnogapi.embl.de/nog_data/html/tree/COG0507 eggNOG ENOG4107QYX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QYX epestfind swissprot:RECD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RECD_ECOLI garnier swissprot:RECD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RECD_ECOLI helixturnhelix swissprot:RECD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RECD_ECOLI hmoment swissprot:RECD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RECD_ECOLI iep swissprot:RECD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RECD_ECOLI inforesidue swissprot:RECD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RECD_ECOLI octanol swissprot:RECD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RECD_ECOLI pepcoil swissprot:RECD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RECD_ECOLI pepdigest swissprot:RECD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RECD_ECOLI pepinfo swissprot:RECD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RECD_ECOLI pepnet swissprot:RECD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RECD_ECOLI pepstats swissprot:RECD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RECD_ECOLI pepwheel swissprot:RECD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RECD_ECOLI pepwindow swissprot:RECD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RECD_ECOLI sigcleave swissprot:RECD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RECD_ECOLI ## Database ID URL or Descriptions # BioGrid 4259328 18 # EcoGene EG10539 livJ # FUNCTION LIVJ_ECOLI This protein is a component of the leucine, isoleucine, valine, (threonine) transport system, which is one of the two periplasmic binding protein-dependent transport systems of the high-affinity transport of the branched-chain amino acids. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0015658 branched-chain amino acid transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0015803 branched-chain amino acid transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # IntAct P0AD96 4 # InterPro IPR000709 Leu_Ile_Val-bd # InterPro IPR028081 Leu-bd # InterPro IPR028082 Peripla_BP_I # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00237 Branched-chain amino acid transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism LIVJ_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30483:SF16 PTHR30483:SF16 # PATRIC 32122364 VBIEscCol129921_3559 # PDB 1Z15 X-ray; 1.70 A; A=24-367 # PDB 1Z16 X-ray; 1.72 A; A=24-367 # PDB 1Z17 X-ray; 1.96 A; A=24-367 # PDB 1Z18 X-ray; 2.10 A; A=24-367 # PDB 2LIV X-ray; 2.40 A; A=24-367 # PIR G65142 BLEC # PRINTS PR00337 LEUILEVALBP # Pfam PF13458 Peripla_BP_6 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LIVJ_ECOLI Leu/Ile/Val-binding protein # RefSeq YP_026223 NC_000913.3 # SEQUENCE CAUTION Sequence=AAB18435.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the leucine-binding protein family. {ECO 0000305}. # SUBCELLULAR LOCATION LIVJ_ECOLI Periplasm. # SUPFAM SSF53822 SSF53822 # TCDB 3.A.1.4 the atp-binding cassette (abc) superfamily # eggNOG COG0683 LUCA # eggNOG ENOG4105CP9 Bacteria BLAST swissprot:LIVJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LIVJ_ECOLI BioCyc ECOL316407:JW3425-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3425-MONOMER BioCyc EcoCyc:LIVJ-MONOMER http://biocyc.org/getid?id=EcoCyc:LIVJ-MONOMER BioCyc MetaCyc:LIVJ-MONOMER http://biocyc.org/getid?id=MetaCyc:LIVJ-MONOMER COG COG0683 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0683 DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1002/jcb.240290305 http://dx.doi.org/10.1002/jcb.240290305 DOI 10.1016/0014-5793(77)80331-1 http://dx.doi.org/10.1016/0014-5793(77)80331-1 DOI 10.1016/0022-2836(89)90531-7 http://dx.doi.org/10.1016/0022-2836(89)90531-7 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J05516 http://www.ebi.ac.uk/ena/data/view/J05516 EMBL M29377 http://www.ebi.ac.uk/ena/data/view/M29377 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0534 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0534 EcoGene EG10539 http://www.ecogene.org/geneInfo.php?eg_id=EG10539 EnsemblBacteria AAT48185 http://www.ensemblgenomes.org/id/AAT48185 EnsemblBacteria AAT48185 http://www.ensemblgenomes.org/id/AAT48185 EnsemblBacteria BAE77833 http://www.ensemblgenomes.org/id/BAE77833 EnsemblBacteria BAE77833 http://www.ensemblgenomes.org/id/BAE77833 EnsemblBacteria BAE77833 http://www.ensemblgenomes.org/id/BAE77833 EnsemblBacteria b3460 http://www.ensemblgenomes.org/id/b3460 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0015658 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015658 GO_process GO:0015803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015803 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 947971 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947971 HOGENOM HOG000130989 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000130989&db=HOGENOM6 InParanoid P0AD96 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AD96 IntAct P0AD96 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AD96* InterPro IPR000709 http://www.ebi.ac.uk/interpro/entry/IPR000709 InterPro IPR028081 http://www.ebi.ac.uk/interpro/entry/IPR028081 InterPro IPR028082 http://www.ebi.ac.uk/interpro/entry/IPR028082 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3425 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3425 KEGG_Gene eco:b3460 http://www.genome.jp/dbget-bin/www_bget?eco:b3460 KEGG_Orthology KO:K01999 http://www.genome.jp/dbget-bin/www_bget?KO:K01999 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA LWNVARV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LWNVARV PANTHER PTHR30483:SF16 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30483:SF16 PDB 1Z15 http://www.ebi.ac.uk/pdbe-srv/view/entry/1Z15 PDB 1Z16 http://www.ebi.ac.uk/pdbe-srv/view/entry/1Z16 PDB 1Z17 http://www.ebi.ac.uk/pdbe-srv/view/entry/1Z17 PDB 1Z18 http://www.ebi.ac.uk/pdbe-srv/view/entry/1Z18 PDB 2LIV http://www.ebi.ac.uk/pdbe-srv/view/entry/2LIV PDBsum 1Z15 http://www.ebi.ac.uk/pdbsum/1Z15 PDBsum 1Z16 http://www.ebi.ac.uk/pdbsum/1Z16 PDBsum 1Z17 http://www.ebi.ac.uk/pdbsum/1Z17 PDBsum 1Z18 http://www.ebi.ac.uk/pdbsum/1Z18 PDBsum 2LIV http://www.ebi.ac.uk/pdbsum/2LIV PRINTS PR00337 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00337 PSORT swissprot:LIVJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LIVJ_ECOLI PSORT-B swissprot:LIVJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LIVJ_ECOLI PSORT2 swissprot:LIVJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LIVJ_ECOLI Pfam PF13458 http://pfam.xfam.org/family/PF13458 Phobius swissprot:LIVJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LIVJ_ECOLI PhylomeDB P0AD96 http://phylomedb.org/?seqid=P0AD96 ProteinModelPortal P0AD96 http://www.proteinmodelportal.org/query/uniprot/P0AD96 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2195019 http://www.ncbi.nlm.nih.gov/pubmed/2195019 PubMed 2649682 http://www.ncbi.nlm.nih.gov/pubmed/2649682 PubMed 328304 http://www.ncbi.nlm.nih.gov/pubmed/328304 PubMed 3891753 http://www.ncbi.nlm.nih.gov/pubmed/3891753 PubMed 4077929 http://www.ncbi.nlm.nih.gov/pubmed/4077929 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq YP_026223 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026223 SMR P0AD96 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AD96 STRING 511145.b3460 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3460&targetmode=cogs STRING COG0683 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0683&targetmode=cogs SUPFAM SSF53822 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822 SWISS-2DPAGE P0AD96 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AD96 TCDB 3.A.1.4 http://www.tcdb.org/search/result.php?tc=3.A.1.4 UniProtKB LIVJ_ECOLI http://www.uniprot.org/uniprot/LIVJ_ECOLI UniProtKB-AC P0AD96 http://www.uniprot.org/uniprot/P0AD96 charge swissprot:LIVJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LIVJ_ECOLI eggNOG COG0683 http://eggnogapi.embl.de/nog_data/html/tree/COG0683 eggNOG ENOG4105CP9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CP9 epestfind swissprot:LIVJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LIVJ_ECOLI garnier swissprot:LIVJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LIVJ_ECOLI helixturnhelix swissprot:LIVJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LIVJ_ECOLI hmoment swissprot:LIVJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LIVJ_ECOLI iep swissprot:LIVJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LIVJ_ECOLI inforesidue swissprot:LIVJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LIVJ_ECOLI octanol swissprot:LIVJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LIVJ_ECOLI pepcoil swissprot:LIVJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LIVJ_ECOLI pepdigest swissprot:LIVJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LIVJ_ECOLI pepinfo swissprot:LIVJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LIVJ_ECOLI pepnet swissprot:LIVJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LIVJ_ECOLI pepstats swissprot:LIVJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LIVJ_ECOLI pepwheel swissprot:LIVJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LIVJ_ECOLI pepwindow swissprot:LIVJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LIVJ_ECOLI sigcleave swissprot:LIVJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LIVJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4263471 8 # EcoGene EG11651 yafE # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0008757 S-adenosylmethionine-dependent methyltransferase activity; IBA:GO_Central. # GO_process GO:0032259 methylation; IBA:GO_Central. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.150 -; 1. # InterPro IPR013216 Methyltransf_11 # InterPro IPR029063 SAM-dependent_MTases # Organism YAFE_ECOLI Escherichia coli (strain K12) # PATRIC 32115533 VBIEscCol129921_0212 # PIR JS0718 JS0718 # Pfam PF08241 Methyltransf_11 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAFE_ECOLI Uncharacterized protein YafE # RefSeq NP_414746 NC_000913.3 # RefSeq WP_000016007 NZ_LN832404.1 # SIMILARITY Belongs to the methyltransferase superfamily. {ECO 0000305}. # SUPFAM SSF53335 SSF53335 # eggNOG COG0500 LUCA # eggNOG ENOG4105F2W Bacteria BLAST swissprot:YAFE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAFE_ECOLI BioCyc ECOL316407:JW0200-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0200-MONOMER BioCyc EcoCyc:EG11651-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11651-MONOMER DOI 10.1016/0378-1097(91)90355-E http://dx.doi.org/10.1016/0378-1097(91)90355-E DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D12650 http://www.ebi.ac.uk/ena/data/view/D12650 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EMBL X60739 http://www.ebi.ac.uk/ena/data/view/X60739 EchoBASE EB1604 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1604 EcoGene EG11651 http://www.ecogene.org/geneInfo.php?eg_id=EG11651 EnsemblBacteria AAC73315 http://www.ensemblgenomes.org/id/AAC73315 EnsemblBacteria AAC73315 http://www.ensemblgenomes.org/id/AAC73315 EnsemblBacteria BAA77881 http://www.ensemblgenomes.org/id/BAA77881 EnsemblBacteria BAA77881 http://www.ensemblgenomes.org/id/BAA77881 EnsemblBacteria BAA77881 http://www.ensemblgenomes.org/id/BAA77881 EnsemblBacteria b0210 http://www.ensemblgenomes.org/id/b0210 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0008757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008757 GO_process GO:0032259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032259 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 GeneID 946197 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946197 HOGENOM HOG000263425 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000263425&db=HOGENOM6 InParanoid P30866 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30866 InterPro IPR013216 http://www.ebi.ac.uk/interpro/entry/IPR013216 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 KEGG_Gene ecj:JW0200 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0200 KEGG_Gene eco:b0210 http://www.genome.jp/dbget-bin/www_bget?eco:b0210 OMA NNEYDTF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NNEYDTF PSORT swissprot:YAFE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAFE_ECOLI PSORT-B swissprot:YAFE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAFE_ECOLI PSORT2 swissprot:YAFE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAFE_ECOLI Pfam PF08241 http://pfam.xfam.org/family/PF08241 Phobius swissprot:YAFE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAFE_ECOLI PhylomeDB P30866 http://phylomedb.org/?seqid=P30866 ProteinModelPortal P30866 http://www.proteinmodelportal.org/query/uniprot/P30866 PubMed 1663890 http://www.ncbi.nlm.nih.gov/pubmed/1663890 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414746 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414746 RefSeq WP_000016007 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000016007 SMR P30866 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P30866 STRING 511145.b0210 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0210&targetmode=cogs SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 UniProtKB YAFE_ECOLI http://www.uniprot.org/uniprot/YAFE_ECOLI UniProtKB-AC P30866 http://www.uniprot.org/uniprot/P30866 charge swissprot:YAFE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAFE_ECOLI eggNOG COG0500 http://eggnogapi.embl.de/nog_data/html/tree/COG0500 eggNOG ENOG4105F2W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F2W epestfind swissprot:YAFE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAFE_ECOLI garnier swissprot:YAFE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAFE_ECOLI helixturnhelix swissprot:YAFE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAFE_ECOLI hmoment swissprot:YAFE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAFE_ECOLI iep swissprot:YAFE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAFE_ECOLI inforesidue swissprot:YAFE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAFE_ECOLI octanol swissprot:YAFE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAFE_ECOLI pepcoil swissprot:YAFE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAFE_ECOLI pepdigest swissprot:YAFE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAFE_ECOLI pepinfo swissprot:YAFE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAFE_ECOLI pepnet swissprot:YAFE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAFE_ECOLI pepstats swissprot:YAFE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAFE_ECOLI pepwheel swissprot:YAFE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAFE_ECOLI pepwindow swissprot:YAFE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAFE_ECOLI sigcleave swissprot:YAFE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAFE_ECOLI ## Database ID URL or Descriptions # AltName SUMT {ECO:0000255|HAMAP-Rule MF_01646} # AltName Uroporphyrinogen III methylase {ECO:0000255|HAMAP-Rule MF_01646} # BioGrid 4262478 6 # CATALYTIC ACTIVITY Precorrin-2 + NAD(+) = sirohydrochlorin + NADH. {ECO:0000255|HAMAP-Rule MF_01646}. # CATALYTIC ACTIVITY S-adenosyl-L-methionine + precorrin-1 = S- adenosyl-L-homocysteine + precorrin-2. {ECO:0000255|HAMAP- Rule MF_01646}. # CATALYTIC ACTIVITY S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L-homocysteine + precorrin-1. {ECO:0000255|HAMAP- Rule MF_01646}. # CATALYTIC ACTIVITY Siroheme + 2 H(+) = sirohydrochlorin + Fe(2+). {ECO:0000255|HAMAP-Rule MF_01646}. # EcoGene EG10188 cysG # FUNCTION CYSG_ECOLI Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. {ECO 0000255|HAMAP- Rule MF_01646, ECO 0000269|PubMed 2407234, ECO 0000269|PubMed 2407558, ECO 0000269|PubMed 8243665, ECO 0000269|PubMed 8573073, ECO 0000269|PubMed 9461500}. # GO_function GO:0004851 uroporphyrin-III C-methyltransferase activity; IDA:EcoCyc. # GO_function GO:0043115 precorrin-2 dehydrogenase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0051266 sirohydrochlorin ferrochelatase activity; IEA:UniProtKB-EC. # GO_function GO:0051287 NAD binding; IEA:InterPro. # GO_process GO:0006970 response to osmotic stress; IMP:EcoCyc. # GO_process GO:0009236 cobalamin biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0019354 siroheme biosynthetic process; IEA:UniProtKB-HAMAP. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008168 methyltransferase activity # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 1.10.8.210 -; 1. # Gene3D 3.30.950.10 -; 1. # Gene3D 3.40.1010.10 -; 1. # Gene3D 3.40.50.720 -; 1. # HAMAP MF_01646 Siroheme_synth # InterPro IPR000878 4pyrrol_Mease # InterPro IPR003043 Uropor_MeTrfase_CS # InterPro IPR006366 CobA/CysG_C # InterPro IPR006367 Sirohaem_synthase_N # InterPro IPR012409 Sirohaem_synth # InterPro IPR014776 4pyrrole_Mease_sub2 # InterPro IPR014777 4pyrrole_Mease_sub1 # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR019478 Sirohaem_synthase_dimer_dom # InterPro IPR028281 Sirohaem_synthase_central # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00860 Porphyrin and chlorophyll metabolism # Organism CYSG_ECOLI Escherichia coli (strain K12) # PATHWAY Cofactor biosynthesis; adenosylcobalamin biosynthesis; precorrin-2 from uroporphyrinogen III: step 1/1. {ECO 0000255|HAMAP-Rule:MF_01646}. # PATHWAY Cofactor biosynthesis; adenosylcobalamin biosynthesis; sirohydrochlorin from precorrin-2: step 1/1. {ECO 0000255|HAMAP- Rule:MF_01646}. # PATHWAY Porphyrin-containing compound metabolism; siroheme biosynthesis; precorrin-2 from uroporphyrinogen III: step 1/1. {ECO 0000255|HAMAP-Rule:MF_01646}. # PATHWAY Porphyrin-containing compound metabolism; siroheme biosynthesis; siroheme from sirohydrochlorin: step 1/1. {ECO 0000255|HAMAP-Rule:MF_01646}. # PATHWAY Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1. {ECO 0000255|HAMAP-Rule:MF_01646}. # PATRIC 32122170 VBIEscCol129921_3462 # PIR C65131 C65131 # PIRSF PIRSF036426 Sirohaem_synth # PROSITE PS00839 SUMT_1 # PROSITE PS00840 SUMT_2 # Pfam PF00590 TP_methylase # Pfam PF10414 CysG_dimeriser # Pfam PF13241 NAD_binding_7 # Pfam PF14824 Sirohm_synth_M # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Precorrin-2 dehydrogenase {ECO:0000255|HAMAP-Rule MF_01646} # RecName Siroheme synthase {ECO:0000255|HAMAP-Rule MF_01646} # RecName Siroheme synthase {ECO:0000255|HAMAP-Rule MF_01646} # RecName Sirohydrochlorin ferrochelatase {ECO:0000255|HAMAP-Rule MF_01646} # RecName Uroporphyrinogen-III C-methyltransferase {ECO:0000255|HAMAP-Rule MF_01646} # RefSeq NP_417827 NC_000913.3 # RefSeq WP_000349855 NZ_LN832404.1 # SIMILARITY In the C-terminal section; belongs to the precorrin methyltransferase family. {ECO:0000255|HAMAP-Rule MF_01646}. # SIMILARITY In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. {ECO:0000255|HAMAP-Rule MF_01646}. # SUBUNIT Monomer. {ECO:0000269|PubMed 2407234}. # SUPFAM SSF51735 SSF51735 # SUPFAM SSF53790 SSF53790 # TIGRFAMs TIGR01469 cobA_cysG_Cterm # TIGRFAMs TIGR01470 cysG_Nterm # UniPathway UPA00148 UER00211 # UniPathway UPA00148 UER00222 # UniPathway UPA00262 UER00211 # UniPathway UPA00262 UER00222 # UniPathway UPA00262 UER00376 # eggNOG COG0007 LUCA # eggNOG COG1648 LUCA # eggNOG ENOG4105CB8 Bacteria BLAST swissprot:CYSG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CYSG_ECOLI BioCyc ECOL316407:JW3331-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3331-MONOMER BioCyc EcoCyc:SIROHEMESYN-MONOMER http://biocyc.org/getid?id=EcoCyc:SIROHEMESYN-MONOMER BioCyc MetaCyc:SIROHEMESYN-MONOMER http://biocyc.org/getid?id=MetaCyc:SIROHEMESYN-MONOMER COG COG0007 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0007 COG COG1648 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1648 DOI 10.1016/0014-5793(90)80640-5 http://dx.doi.org/10.1016/0014-5793(90)80640-5 DOI 10.1016/0014-5793(93)80438-Z http://dx.doi.org/10.1016/0014-5793(93)80438-Z DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2650725 http://dx.doi.org/10.1042/bj2650725 DOI 10.1042/bj3130415 http://dx.doi.org/10.1042/bj3130415 DOI 10.1042/bj3300121 http://dx.doi.org/10.1042/bj3300121 DOI 10.1093/nar/17.10.3865 http://dx.doi.org/10.1093/nar/17.10.3865 DOI 10.1111/j.1432-1033.1990.tb19125.x http://dx.doi.org/10.1111/j.1432-1033.1990.tb19125.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.3.1.76 {ECO:0000255|HAMAP-Rule:MF_01646} http://www.genome.jp/dbget-bin/www_bget?EC:1.3.1.76 {ECO:0000255|HAMAP-Rule:MF_01646} EC_number EC:2.1.1.107 {ECO:0000255|HAMAP-Rule:MF_01646} http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.107 {ECO:0000255|HAMAP-Rule:MF_01646} EC_number EC:4.99.1.4 {ECO:0000255|HAMAP-Rule:MF_01646} http://www.genome.jp/dbget-bin/www_bget?EC:4.99.1.4 {ECO:0000255|HAMAP-Rule:MF_01646} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X14202 http://www.ebi.ac.uk/ena/data/view/X14202 ENZYME 1.3.1.76 {ECO:0000255|HAMAP-Rule:MF_01646} http://enzyme.expasy.org/EC/1.3.1.76 {ECO:0000255|HAMAP-Rule:MF_01646} ENZYME 2.1.1.107 {ECO:0000255|HAMAP-Rule:MF_01646} http://enzyme.expasy.org/EC/2.1.1.107 {ECO:0000255|HAMAP-Rule:MF_01646} ENZYME 4.99.1.4 {ECO:0000255|HAMAP-Rule:MF_01646} http://enzyme.expasy.org/EC/4.99.1.4 {ECO:0000255|HAMAP-Rule:MF_01646} EchoBASE EB0185 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0185 EcoGene EG10188 http://www.ecogene.org/geneInfo.php?eg_id=EG10188 EnsemblBacteria AAC76393 http://www.ensemblgenomes.org/id/AAC76393 EnsemblBacteria AAC76393 http://www.ensemblgenomes.org/id/AAC76393 EnsemblBacteria BAE77922 http://www.ensemblgenomes.org/id/BAE77922 EnsemblBacteria BAE77922 http://www.ensemblgenomes.org/id/BAE77922 EnsemblBacteria BAE77922 http://www.ensemblgenomes.org/id/BAE77922 EnsemblBacteria b3368 http://www.ensemblgenomes.org/id/b3368 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004851 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004851 GO_function GO:0043115 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043115 GO_function GO:0051266 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051266 GO_function GO:0051287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051287 GO_process GO:0006970 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006970 GO_process GO:0009236 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009236 GO_process GO:0019354 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019354 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 1.10.8.210 http://www.cathdb.info/version/latest/superfamily/1.10.8.210 Gene3D 3.30.950.10 http://www.cathdb.info/version/latest/superfamily/3.30.950.10 Gene3D 3.40.1010.10 http://www.cathdb.info/version/latest/superfamily/3.40.1010.10 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 947880 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947880 HAMAP MF_01646 http://hamap.expasy.org/unirule/MF_01646 HOGENOM HOG000290518 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000290518&db=HOGENOM6 InParanoid P0AEA8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEA8 IntAct P0AEA8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEA8* IntEnz 1.3.1.76 {ECO:0000255|HAMAP-Rule:MF_01646} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.3.1.76 {ECO:0000255|HAMAP-Rule:MF_01646} IntEnz 2.1.1.107 {ECO:0000255|HAMAP-Rule:MF_01646} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.107 {ECO:0000255|HAMAP-Rule:MF_01646} IntEnz 4.99.1.4 {ECO:0000255|HAMAP-Rule:MF_01646} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.99.1.4 {ECO:0000255|HAMAP-Rule:MF_01646} InterPro IPR000878 http://www.ebi.ac.uk/interpro/entry/IPR000878 InterPro IPR003043 http://www.ebi.ac.uk/interpro/entry/IPR003043 InterPro IPR006366 http://www.ebi.ac.uk/interpro/entry/IPR006366 InterPro IPR006367 http://www.ebi.ac.uk/interpro/entry/IPR006367 InterPro IPR012409 http://www.ebi.ac.uk/interpro/entry/IPR012409 InterPro IPR014776 http://www.ebi.ac.uk/interpro/entry/IPR014776 InterPro IPR014777 http://www.ebi.ac.uk/interpro/entry/IPR014777 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR019478 http://www.ebi.ac.uk/interpro/entry/IPR019478 InterPro IPR028281 http://www.ebi.ac.uk/interpro/entry/IPR028281 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3331 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3331 KEGG_Gene eco:b3368 http://www.genome.jp/dbget-bin/www_bget?eco:b3368 KEGG_Orthology KO:K02302 http://www.genome.jp/dbget-bin/www_bget?KO:K02302 KEGG_Pathway ko00860 http://www.genome.jp/kegg-bin/show_pathway?ko00860 KEGG_Reaction rn:R02864 http://www.genome.jp/dbget-bin/www_bget?rn:R02864 KEGG_Reaction rn:R03194 http://www.genome.jp/dbget-bin/www_bget?rn:R03194 KEGG_Reaction rn:R03947 http://www.genome.jp/dbget-bin/www_bget?rn:R03947 OMA QASFIMP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QASFIMP PROSITE PS00839 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00839 PROSITE PS00840 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00840 PSORT swissprot:CYSG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CYSG_ECOLI PSORT-B swissprot:CYSG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CYSG_ECOLI PSORT2 swissprot:CYSG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CYSG_ECOLI Pfam PF00590 http://pfam.xfam.org/family/PF00590 Pfam PF10414 http://pfam.xfam.org/family/PF10414 Pfam PF13241 http://pfam.xfam.org/family/PF13241 Pfam PF14824 http://pfam.xfam.org/family/PF14824 Phobius swissprot:CYSG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CYSG_ECOLI PhylomeDB P0AEA8 http://phylomedb.org/?seqid=P0AEA8 ProteinModelPortal P0AEA8 http://www.proteinmodelportal.org/query/uniprot/P0AEA8 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2200672 http://www.ncbi.nlm.nih.gov/pubmed/2200672 PubMed 2407234 http://www.ncbi.nlm.nih.gov/pubmed/2407234 PubMed 2407558 http://www.ncbi.nlm.nih.gov/pubmed/2407558 PubMed 2543955 http://www.ncbi.nlm.nih.gov/pubmed/2543955 PubMed 8243665 http://www.ncbi.nlm.nih.gov/pubmed/8243665 PubMed 8573073 http://www.ncbi.nlm.nih.gov/pubmed/8573073 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9461500 http://www.ncbi.nlm.nih.gov/pubmed/9461500 RefSeq NP_417827 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417827 RefSeq WP_000349855 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000349855 SMR P0AEA8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEA8 STRING 511145.b3368 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3368&targetmode=cogs STRING COG0007 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0007&targetmode=cogs STRING COG1648 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1648&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 SUPFAM SSF53790 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53790 TIGRFAMs TIGR01469 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01469 TIGRFAMs TIGR01470 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01470 UniProtKB CYSG_ECOLI http://www.uniprot.org/uniprot/CYSG_ECOLI UniProtKB-AC P0AEA8 http://www.uniprot.org/uniprot/P0AEA8 charge swissprot:CYSG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CYSG_ECOLI eggNOG COG0007 http://eggnogapi.embl.de/nog_data/html/tree/COG0007 eggNOG COG1648 http://eggnogapi.embl.de/nog_data/html/tree/COG1648 eggNOG ENOG4105CB8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CB8 epestfind swissprot:CYSG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CYSG_ECOLI garnier swissprot:CYSG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CYSG_ECOLI helixturnhelix swissprot:CYSG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CYSG_ECOLI hmoment swissprot:CYSG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CYSG_ECOLI iep swissprot:CYSG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CYSG_ECOLI inforesidue swissprot:CYSG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CYSG_ECOLI octanol swissprot:CYSG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CYSG_ECOLI pepcoil swissprot:CYSG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CYSG_ECOLI pepdigest swissprot:CYSG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CYSG_ECOLI pepinfo swissprot:CYSG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CYSG_ECOLI pepnet swissprot:CYSG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CYSG_ECOLI pepstats swissprot:CYSG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CYSG_ECOLI pepwheel swissprot:CYSG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CYSG_ECOLI pepwindow swissprot:CYSG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CYSG_ECOLI sigcleave swissprot:CYSG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CYSG_ECOLI ## Database ID URL or Descriptions # BioGrid 4261473 10 # EcoGene EG11450 yifE # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # IntAct P0ADN2 6 # InterPro IPR007335 DUF413 # Organism YIFE_ECOLI Escherichia coli (strain K12) # PATRIC 32123025 VBIEscCol129921_3882 # PIR G65179 G65179 # Pfam PF04219 DUF413 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIFE_ECOLI UPF0438 protein YifE # RefSeq NP_418213 NC_000913.3 # RefSeq WP_000841001 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA67568.1; Type=Frameshift; Positions=3; Evidence={ECO 0000305}; # SIMILARITY Belongs to the UPF0438 family. {ECO 0000305}. # eggNOG COG3085 LUCA # eggNOG ENOG4108WFC Bacteria BLAST swissprot:YIFE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIFE_ECOLI BioCyc ECOL316407:JW3737-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3737-MONOMER BioCyc EcoCyc:EG11450-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11450-MONOMER COG COG3085 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3085 DIP DIP-48206N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48206N DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1016/0378-1119(91)90005-V http://dx.doi.org/10.1016/0378-1119(91)90005-V DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M37337 http://www.ebi.ac.uk/ena/data/view/M37337 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1419 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1419 EcoGene EG11450 http://www.ecogene.org/geneInfo.php?eg_id=EG11450 EnsemblBacteria AAC77485 http://www.ensemblgenomes.org/id/AAC77485 EnsemblBacteria AAC77485 http://www.ensemblgenomes.org/id/AAC77485 EnsemblBacteria BAE77531 http://www.ensemblgenomes.org/id/BAE77531 EnsemblBacteria BAE77531 http://www.ensemblgenomes.org/id/BAE77531 EnsemblBacteria BAE77531 http://www.ensemblgenomes.org/id/BAE77531 EnsemblBacteria b3764 http://www.ensemblgenomes.org/id/b3764 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GeneID 948274 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948274 HOGENOM HOG000293081 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000293081&db=HOGENOM6 IntAct P0ADN2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADN2* InterPro IPR007335 http://www.ebi.ac.uk/interpro/entry/IPR007335 KEGG_Gene ecj:JW3737 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3737 KEGG_Gene eco:b3764 http://www.genome.jp/dbget-bin/www_bget?eco:b3764 KEGG_Orthology KO:K09897 http://www.genome.jp/dbget-bin/www_bget?KO:K09897 OMA QFVAVCR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QFVAVCR PSORT swissprot:YIFE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIFE_ECOLI PSORT-B swissprot:YIFE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIFE_ECOLI PSORT2 swissprot:YIFE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIFE_ECOLI Pfam PF04219 http://pfam.xfam.org/family/PF04219 Phobius swissprot:YIFE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIFE_ECOLI ProteinModelPortal P0ADN2 http://www.proteinmodelportal.org/query/uniprot/P0ADN2 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 1995430 http://www.ncbi.nlm.nih.gov/pubmed/1995430 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_418213 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418213 RefSeq WP_000841001 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000841001 STRING 511145.b3764 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3764&targetmode=cogs STRING COG3085 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3085&targetmode=cogs UniProtKB YIFE_ECOLI http://www.uniprot.org/uniprot/YIFE_ECOLI UniProtKB-AC P0ADN2 http://www.uniprot.org/uniprot/P0ADN2 charge swissprot:YIFE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIFE_ECOLI eggNOG COG3085 http://eggnogapi.embl.de/nog_data/html/tree/COG3085 eggNOG ENOG4108WFC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108WFC epestfind swissprot:YIFE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIFE_ECOLI garnier swissprot:YIFE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIFE_ECOLI helixturnhelix swissprot:YIFE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIFE_ECOLI hmoment swissprot:YIFE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIFE_ECOLI iep swissprot:YIFE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIFE_ECOLI inforesidue swissprot:YIFE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIFE_ECOLI octanol swissprot:YIFE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIFE_ECOLI pepcoil swissprot:YIFE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIFE_ECOLI pepdigest swissprot:YIFE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIFE_ECOLI pepinfo swissprot:YIFE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIFE_ECOLI pepnet swissprot:YIFE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIFE_ECOLI pepstats swissprot:YIFE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIFE_ECOLI pepwheel swissprot:YIFE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIFE_ECOLI pepwindow swissprot:YIFE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIFE_ECOLI sigcleave swissprot:YIFE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIFE_ECOLI ## Database ID URL or Descriptions # BioGrid 4263141 8 # CDD cd06660 Aldo_ket_red # EcoGene EG13093 tas # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004033 aldo-keto reductase (NADP) activity; NAS:EcoCyc. # GO_process GO:0034198 cellular response to amino acid starvation; IMP:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006950 response to stress # Gene3D 3.20.20.100 -; 1. # IntAct P0A9T4 2 # InterPro IPR001395 Aldo/ket_red/Kv-b # InterPro IPR020471 Aldo/keto_reductase # InterPro IPR023210 NADP_OxRdtase_dom # Organism TAS_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11732 PTHR11732; 2 # PATRIC 32121086 VBIEscCol129921_2932 # PDB 1LQA X-ray; 1.60 A; A/B=1-346 # PIR C65066 C65066 # PRINTS PR00069 ALDKETRDTASE # Pfam PF00248 Aldo_ket_red # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TAS_ECOLI Protein tas # RefSeq NP_417311 NC_000913.3 # RefSeq WP_001199295 NZ_LN832404.1 # SIMILARITY Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily. {ECO 0000305}. # SUPFAM SSF51430 SSF51430 # TCDB 8.A.5.1 the voltage-gated k(+) channel -subunit (kv) family # eggNOG COG0667 LUCA # eggNOG ENOG4105CPC Bacteria BLAST swissprot:TAS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TAS_ECOLI BioCyc ECOL316407:JW2802-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2802-MONOMER BioCyc EcoCyc:G7462-MONOMER http://biocyc.org/getid?id=EcoCyc:G7462-MONOMER DIP DIP-48107N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48107N DOI 10.1002/prot.10367 http://dx.doi.org/10.1002/prot.10367 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 EMBL Y14609 http://www.ebi.ac.uk/ena/data/view/Y14609 EchoBASE EB2898 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2898 EcoGene EG13093 http://www.ecogene.org/geneInfo.php?eg_id=EG13093 EnsemblBacteria AAC75873 http://www.ensemblgenomes.org/id/AAC75873 EnsemblBacteria AAC75873 http://www.ensemblgenomes.org/id/AAC75873 EnsemblBacteria BAE76903 http://www.ensemblgenomes.org/id/BAE76903 EnsemblBacteria BAE76903 http://www.ensemblgenomes.org/id/BAE76903 EnsemblBacteria BAE76903 http://www.ensemblgenomes.org/id/BAE76903 EnsemblBacteria b2834 http://www.ensemblgenomes.org/id/b2834 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004033 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004033 GO_process GO:0034198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034198 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.20.20.100 http://www.cathdb.info/version/latest/superfamily/3.20.20.100 GeneID 947306 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947306 HOGENOM HOG000250270 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000250270&db=HOGENOM6 InParanoid P0A9T4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9T4 IntAct P0A9T4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9T4* InterPro IPR001395 http://www.ebi.ac.uk/interpro/entry/IPR001395 InterPro IPR020471 http://www.ebi.ac.uk/interpro/entry/IPR020471 InterPro IPR023210 http://www.ebi.ac.uk/interpro/entry/IPR023210 KEGG_Gene ecj:JW2802 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2802 KEGG_Gene eco:b2834 http://www.genome.jp/dbget-bin/www_bget?eco:b2834 OMA FGKLGYQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FGKLGYQ PANTHER PTHR11732 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11732 PDB 1LQA http://www.ebi.ac.uk/pdbe-srv/view/entry/1LQA PDBsum 1LQA http://www.ebi.ac.uk/pdbsum/1LQA PRINTS PR00069 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00069 PSORT swissprot:TAS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TAS_ECOLI PSORT-B swissprot:TAS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TAS_ECOLI PSORT2 swissprot:TAS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TAS_ECOLI Pfam PF00248 http://pfam.xfam.org/family/PF00248 Phobius swissprot:TAS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TAS_ECOLI PhylomeDB P0A9T4 http://phylomedb.org/?seqid=P0A9T4 ProteinModelPortal P0A9T4 http://www.proteinmodelportal.org/query/uniprot/P0A9T4 PubMed 14517983 http://www.ncbi.nlm.nih.gov/pubmed/14517983 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9560382 http://www.ncbi.nlm.nih.gov/pubmed/9560382 RefSeq NP_417311 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417311 RefSeq WP_001199295 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001199295 SMR P0A9T4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9T4 STRING 511145.b2834 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2834&targetmode=cogs SUPFAM SSF51430 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51430 TCDB 8.A.5.1 http://www.tcdb.org/search/result.php?tc=8.A.5.1 UniProtKB TAS_ECOLI http://www.uniprot.org/uniprot/TAS_ECOLI UniProtKB-AC P0A9T4 http://www.uniprot.org/uniprot/P0A9T4 charge swissprot:TAS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TAS_ECOLI eggNOG COG0667 http://eggnogapi.embl.de/nog_data/html/tree/COG0667 eggNOG ENOG4105CPC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CPC epestfind swissprot:TAS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TAS_ECOLI garnier swissprot:TAS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TAS_ECOLI helixturnhelix swissprot:TAS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TAS_ECOLI hmoment swissprot:TAS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TAS_ECOLI iep swissprot:TAS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TAS_ECOLI inforesidue swissprot:TAS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TAS_ECOLI octanol swissprot:TAS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TAS_ECOLI pepcoil swissprot:TAS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TAS_ECOLI pepdigest swissprot:TAS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TAS_ECOLI pepinfo swissprot:TAS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TAS_ECOLI pepnet swissprot:TAS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TAS_ECOLI pepstats swissprot:TAS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TAS_ECOLI pepwheel swissprot:TAS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TAS_ECOLI pepwindow swissprot:TAS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TAS_ECOLI sigcleave swissprot:TAS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TAS_ECOLI ## Database ID URL or Descriptions # BioGrid 4261330 8 # EcoGene EG13608 yaiW # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0031240 external side of cell outer membrane; IDA:EcoCyc. # GO_process GO:1901652 response to peptide; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_process GO:0008150 biological_process # InterPro IPR011673 DUF1615 # Organism YAIW_ECOLI Escherichia coli (strain K12) # PATRIC 32115897 VBIEscCol129921_0390 # PIR B64766 B64766 # Pfam PF07759 DUF1615 # ProDom PD041438 DUF1615 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAIW_ECOLI Uncharacterized protein YaiW # RefSeq NP_414912 NC_000913.3 # RefSeq WP_000092067 NZ_LN832404.1 # eggNOG ENOG4107QS8 Bacteria # eggNOG ENOG410XS0Z LUCA BLAST swissprot:YAIW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAIW_ECOLI BioCyc ECOL316407:JW0369-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0369-MONOMER BioCyc EcoCyc:G6227-MONOMER http://biocyc.org/getid?id=EcoCyc:G6227-MONOMER DIP DIP-11282N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11282N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB3375 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3375 EcoGene EG13608 http://www.ecogene.org/geneInfo.php?eg_id=EG13608 EnsemblBacteria AAC73481 http://www.ensemblgenomes.org/id/AAC73481 EnsemblBacteria AAC73481 http://www.ensemblgenomes.org/id/AAC73481 EnsemblBacteria BAE76159 http://www.ensemblgenomes.org/id/BAE76159 EnsemblBacteria BAE76159 http://www.ensemblgenomes.org/id/BAE76159 EnsemblBacteria BAE76159 http://www.ensemblgenomes.org/id/BAE76159 EnsemblBacteria b0378 http://www.ensemblgenomes.org/id/b0378 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0031240 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031240 GO_process GO:1901652 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901652 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 945038 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945038 HOGENOM HOG000279724 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000279724&db=HOGENOM6 InParanoid P77562 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77562 IntAct P77562 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77562* InterPro IPR011673 http://www.ebi.ac.uk/interpro/entry/IPR011673 KEGG_Gene ecj:JW0369 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0369 KEGG_Gene eco:b0378 http://www.genome.jp/dbget-bin/www_bget?eco:b0378 OMA DFIDMVP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DFIDMVP PSORT swissprot:YAIW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAIW_ECOLI PSORT-B swissprot:YAIW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAIW_ECOLI PSORT2 swissprot:YAIW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAIW_ECOLI Pfam PF07759 http://pfam.xfam.org/family/PF07759 Phobius swissprot:YAIW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAIW_ECOLI ProteinModelPortal P77562 http://www.proteinmodelportal.org/query/uniprot/P77562 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414912 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414912 RefSeq WP_000092067 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000092067 SMR P77562 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77562 STRING 511145.b0378 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0378&targetmode=cogs UniProtKB YAIW_ECOLI http://www.uniprot.org/uniprot/YAIW_ECOLI UniProtKB-AC P77562 http://www.uniprot.org/uniprot/P77562 charge swissprot:YAIW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAIW_ECOLI eggNOG ENOG4107QS8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QS8 eggNOG ENOG410XS0Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XS0Z epestfind swissprot:YAIW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAIW_ECOLI garnier swissprot:YAIW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAIW_ECOLI helixturnhelix swissprot:YAIW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAIW_ECOLI hmoment swissprot:YAIW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAIW_ECOLI iep swissprot:YAIW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAIW_ECOLI inforesidue swissprot:YAIW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAIW_ECOLI octanol swissprot:YAIW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAIW_ECOLI pepcoil swissprot:YAIW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAIW_ECOLI pepdigest swissprot:YAIW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAIW_ECOLI pepinfo swissprot:YAIW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAIW_ECOLI pepnet swissprot:YAIW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAIW_ECOLI pepstats swissprot:YAIW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAIW_ECOLI pepwheel swissprot:YAIW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAIW_ECOLI pepwindow swissprot:YAIW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAIW_ECOLI sigcleave swissprot:YAIW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAIW_ECOLI ## Database ID URL or Descriptions # AltName Nucleoside-transport system protein NupC {ECO 0000305} # BioGrid 4259184 8 # EcoGene EG11971 nupC # FUNCTION NUPC_ECOLI Transports nucleosides with a high affinity except guanosine and deoxyguanosine. Driven by a proton motive force. Transports cytidine, uridine, thymidine, adenosine and inosine. Can also transport xanthosine, but with a very low affinity. {ECO 0000269|PubMed 11466294, ECO 0000269|PubMed 15678184, ECO 0000269|PubMed 374403}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_function GO:0015212 cytidine transmembrane transporter activity; IMP:EcoliWiki. # GO_function GO:0015213 uridine transmembrane transporter activity; IMP:EcoliWiki. # GO_function NUPC_ECOLI GO 0015506 nucleoside proton symporter activity; IDA EcoCyc. # GO_process GO:0015858 nucleoside transport; IMP:EcoCyc. # GO_process GO:1901642 nucleoside transmembrane transport; IMP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # InterPro IPR002668 CNT_N_dom # InterPro IPR008276 C_nuclsd_transpt # InterPro IPR011642 Gate_dom # InterPro IPR011657 CNT_C_dom # InterPro IPR018270 C_nuclsd_transpt_met_bac # KEGG_Brite ko02000 Transporters # MISCELLANEOUS Binding of nucleosides to NupC requires the presence of hydroxyl groups at the C-3' position of ribose. {ECO:0000269|PubMed 15678184}. # Organism NUPC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10590 PTHR10590 # PATRIC 32120163 VBIEscCol129921_2490 # PIR F65013 F65013 # Pfam PF01773 Nucleos_tra2_N # Pfam PF07662 Nucleos_tra2_C # Pfam PF07670 Gate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Nucleoside permease NupC {ECO 0000305} # RefSeq NP_416894 NC_000913.3 # RefSeq WP_000376337 NZ_LN832404.1 # SIMILARITY Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family. {ECO 0000305}. # SUBCELLULAR LOCATION NUPC_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255}. # TCDB 2.A.41.1 the concentrative nucleoside transporter (cnt) family # TIGRFAMs TIGR00804 nupC # eggNOG COG1972 LUCA # eggNOG ENOG4105D9N Bacteria BLAST swissprot:NUPC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NUPC_ECOLI BioCyc ECOL316407:JW2389-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2389-MONOMER BioCyc EcoCyc:NUPC-MONOMER http://biocyc.org/getid?id=EcoCyc:NUPC-MONOMER BioCyc MetaCyc:NUPC-MONOMER http://biocyc.org/getid?id=MetaCyc:NUPC-MONOMER COG COG1972 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1972 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1039/b414739a http://dx.doi.org/10.1039/b414739a DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1365-2958.1994.tb00392.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb00392.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.183.16.4900-4904.2001 http://dx.doi.org/10.1128/JB.183.16.4900-4904.2001 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X74825 http://www.ebi.ac.uk/ena/data/view/X74825 EchoBASE EB1914 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1914 EcoGene EG11971 http://www.ecogene.org/geneInfo.php?eg_id=EG11971 EnsemblBacteria AAC75452 http://www.ensemblgenomes.org/id/AAC75452 EnsemblBacteria AAC75452 http://www.ensemblgenomes.org/id/AAC75452 EnsemblBacteria BAA16263 http://www.ensemblgenomes.org/id/BAA16263 EnsemblBacteria BAA16263 http://www.ensemblgenomes.org/id/BAA16263 EnsemblBacteria BAA16263 http://www.ensemblgenomes.org/id/BAA16263 EnsemblBacteria b2393 http://www.ensemblgenomes.org/id/b2393 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015212 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015212 GO_function GO:0015213 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015213 GO_function GO:0015506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015506 GO_process GO:0015858 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015858 GO_process GO:1901642 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901642 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 946895 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946895 HOGENOM HOG000267657 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267657&db=HOGENOM6 InParanoid P0AFF2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFF2 InterPro IPR002668 http://www.ebi.ac.uk/interpro/entry/IPR002668 InterPro IPR008276 http://www.ebi.ac.uk/interpro/entry/IPR008276 InterPro IPR011642 http://www.ebi.ac.uk/interpro/entry/IPR011642 InterPro IPR011657 http://www.ebi.ac.uk/interpro/entry/IPR011657 InterPro IPR018270 http://www.ebi.ac.uk/interpro/entry/IPR018270 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2389 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2389 KEGG_Gene eco:b2393 http://www.genome.jp/dbget-bin/www_bget?eco:b2393 KEGG_Orthology KO:K11535 http://www.genome.jp/dbget-bin/www_bget?KO:K11535 OMA NEFVAMN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NEFVAMN PANTHER PTHR10590 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10590 PSORT swissprot:NUPC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NUPC_ECOLI PSORT-B swissprot:NUPC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NUPC_ECOLI PSORT2 swissprot:NUPC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NUPC_ECOLI Pfam PF01773 http://pfam.xfam.org/family/PF01773 Pfam PF07662 http://pfam.xfam.org/family/PF07662 Pfam PF07670 http://pfam.xfam.org/family/PF07670 Phobius swissprot:NUPC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NUPC_ECOLI PhylomeDB P0AFF2 http://phylomedb.org/?seqid=P0AFF2 ProteinModelPortal P0AFF2 http://www.proteinmodelportal.org/query/uniprot/P0AFF2 PubMed 11466294 http://www.ncbi.nlm.nih.gov/pubmed/11466294 PubMed 15678184 http://www.ncbi.nlm.nih.gov/pubmed/15678184 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 374403 http://www.ncbi.nlm.nih.gov/pubmed/374403 PubMed 8022285 http://www.ncbi.nlm.nih.gov/pubmed/8022285 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416894 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416894 RefSeq WP_000376337 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000376337 SMR P0AFF2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFF2 STRING 511145.b2393 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2393&targetmode=cogs STRING COG1972 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1972&targetmode=cogs TCDB 2.A.41.1 http://www.tcdb.org/search/result.php?tc=2.A.41.1 TIGRFAMs TIGR00804 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00804 UniProtKB NUPC_ECOLI http://www.uniprot.org/uniprot/NUPC_ECOLI UniProtKB-AC P0AFF2 http://www.uniprot.org/uniprot/P0AFF2 charge swissprot:NUPC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NUPC_ECOLI eggNOG COG1972 http://eggnogapi.embl.de/nog_data/html/tree/COG1972 eggNOG ENOG4105D9N http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D9N epestfind swissprot:NUPC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NUPC_ECOLI garnier swissprot:NUPC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NUPC_ECOLI helixturnhelix swissprot:NUPC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NUPC_ECOLI hmoment swissprot:NUPC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NUPC_ECOLI iep swissprot:NUPC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NUPC_ECOLI inforesidue swissprot:NUPC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NUPC_ECOLI octanol swissprot:NUPC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NUPC_ECOLI pepcoil swissprot:NUPC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NUPC_ECOLI pepdigest swissprot:NUPC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NUPC_ECOLI pepinfo swissprot:NUPC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NUPC_ECOLI pepnet swissprot:NUPC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NUPC_ECOLI pepstats swissprot:NUPC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NUPC_ECOLI pepwheel swissprot:NUPC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NUPC_ECOLI pepwindow swissprot:NUPC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NUPC_ECOLI sigcleave swissprot:NUPC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NUPC_ECOLI ## Database ID URL or Descriptions # BioGrid 4261797 10 # EcoGene EG10752 potD # FUNCTION POTD_ECOLI Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine. Polyamine binding protein. {ECO 0000269|PubMed 1939142}. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0015417 polyamine-transporting ATPase activity; IMP:EcoCyc. # GO_function GO:0019808 polyamine binding; IEA:InterPro. # GO_process GO:0015846 polyamine transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # IntAct P0AFK9 7 # InterPro IPR001188 Sperm_putr-bd # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00299 Spermidine/putrescine transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism POTD_ECOLI Escherichia coli (strain K12) # PATRIC 32117493 VBIEscCol129921_1169 # PDB 1POT X-ray; 1.80 A; A=24-348 # PDB 1POY X-ray; 2.50 A; 1/2/3/4=26-348 # PIR D40840 D40840 # PIRSF PIRSF019574 Periplasmic_polyamine_BP # PRINTS PR00909 SPERMDNBNDNG # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName POTD_ECOLI Spermidine/putrescine-binding periplasmic protein # RefSeq NP_415641 NC_000913.3 # RefSeq WP_000759317 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial solute-binding protein PotD/PotF family. {ECO 0000305}. # SUBCELLULAR LOCATION POTD_ECOLI Periplasm {ECO 0000269|PubMed 1939142}. # TCDB 3.A.1.11 the atp-binding cassette (abc) superfamily # eggNOG COG0687 LUCA # eggNOG ENOG4107RUE Bacteria BLAST swissprot:POTD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:POTD_ECOLI BioCyc ECOL316407:JW1109-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1109-MONOMER BioCyc EcoCyc:POTD-MONOMER http://biocyc.org/getid?id=EcoCyc:POTD-MONOMER BioCyc MetaCyc:POTD-MONOMER http://biocyc.org/getid?id=MetaCyc:POTD-MONOMER COG COG0687 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0687 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1002/pro.5560051004 http://dx.doi.org/10.1002/pro.5560051004 DOI 10.1016/0014-5793(94)00435-8 http://dx.doi.org/10.1016/0014-5793(94)00435-8 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.271.16.9519 http://dx.doi.org/10.1074/jbc.271.16.9519 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M64519 http://www.ebi.ac.uk/ena/data/view/M64519 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0745 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0745 EcoGene EG10752 http://www.ecogene.org/geneInfo.php?eg_id=EG10752 EnsemblBacteria AAC74207 http://www.ensemblgenomes.org/id/AAC74207 EnsemblBacteria AAC74207 http://www.ensemblgenomes.org/id/AAC74207 EnsemblBacteria BAA35943 http://www.ensemblgenomes.org/id/BAA35943 EnsemblBacteria BAA35943 http://www.ensemblgenomes.org/id/BAA35943 EnsemblBacteria BAA35943 http://www.ensemblgenomes.org/id/BAA35943 EnsemblBacteria b1123 http://www.ensemblgenomes.org/id/b1123 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0015417 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015417 GO_function GO:0019808 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019808 GO_process GO:0015846 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015846 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 945682 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945682 HOGENOM HOG000263814 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000263814&db=HOGENOM6 InParanoid P0AFK9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFK9 IntAct P0AFK9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFK9* InterPro IPR001188 http://www.ebi.ac.uk/interpro/entry/IPR001188 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1109 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1109 KEGG_Gene eco:b1123 http://www.genome.jp/dbget-bin/www_bget?eco:b1123 KEGG_Orthology KO:K11069 http://www.genome.jp/dbget-bin/www_bget?KO:K11069 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA MDDSREV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MDDSREV PDB 1POT http://www.ebi.ac.uk/pdbe-srv/view/entry/1POT PDB 1POY http://www.ebi.ac.uk/pdbe-srv/view/entry/1POY PDBsum 1POT http://www.ebi.ac.uk/pdbsum/1POT PDBsum 1POY http://www.ebi.ac.uk/pdbsum/1POY PRINTS PR00909 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00909 PSORT swissprot:POTD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:POTD_ECOLI PSORT-B swissprot:POTD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:POTD_ECOLI PSORT2 swissprot:POTD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:POTD_ECOLI Phobius swissprot:POTD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:POTD_ECOLI PhylomeDB P0AFK9 http://phylomedb.org/?seqid=P0AFK9 ProteinModelPortal P0AFK9 http://www.proteinmodelportal.org/query/uniprot/P0AFK9 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1939142 http://www.ncbi.nlm.nih.gov/pubmed/1939142 PubMed 8194593 http://www.ncbi.nlm.nih.gov/pubmed/8194593 PubMed 8621624 http://www.ncbi.nlm.nih.gov/pubmed/8621624 PubMed 8897598 http://www.ncbi.nlm.nih.gov/pubmed/8897598 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_415641 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415641 RefSeq WP_000759317 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000759317 SMR P0AFK9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFK9 STRING 511145.b1123 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1123&targetmode=cogs STRING COG0687 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0687&targetmode=cogs SWISS-2DPAGE P0AFK9 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AFK9 TCDB 3.A.1.11 http://www.tcdb.org/search/result.php?tc=3.A.1.11 UniProtKB POTD_ECOLI http://www.uniprot.org/uniprot/POTD_ECOLI UniProtKB-AC P0AFK9 http://www.uniprot.org/uniprot/P0AFK9 charge swissprot:POTD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:POTD_ECOLI eggNOG COG0687 http://eggnogapi.embl.de/nog_data/html/tree/COG0687 eggNOG ENOG4107RUE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107RUE epestfind swissprot:POTD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:POTD_ECOLI garnier swissprot:POTD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:POTD_ECOLI helixturnhelix swissprot:POTD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:POTD_ECOLI hmoment swissprot:POTD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:POTD_ECOLI iep swissprot:POTD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:POTD_ECOLI inforesidue swissprot:POTD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:POTD_ECOLI octanol swissprot:POTD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:POTD_ECOLI pepcoil swissprot:POTD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:POTD_ECOLI pepdigest swissprot:POTD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:POTD_ECOLI pepinfo swissprot:POTD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:POTD_ECOLI pepnet swissprot:POTD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:POTD_ECOLI pepstats swissprot:POTD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:POTD_ECOLI pepwheel swissprot:POTD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:POTD_ECOLI pepwindow swissprot:POTD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:POTD_ECOLI sigcleave swissprot:POTD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:POTD_ECOLI ## Database ID URL or Descriptions # BioGrid 4263133 7 # EcoGene EG11624 artP # FUNCTION ARTP_ECOLI Part of the ABC transporter complex ArtPIQMJ involved in arginine transport. Probably responsible for energy coupling to the transport system. {ECO 0000269|PubMed 8801422}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0055052 ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing; ISO:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0015426 polar-amino acid-transporting ATPase activity; ISM:EcoCyc. # GO_process GO:1902765 L-arginine import into cell; IDA:EcoCyc. # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # Gene3D 3.40.50.300 -; 1. # IntAct P0AAF6 12 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # InterPro IPR030679 ABC_ATPase_HisP-typ # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00229 Arginine transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism ARTP_ECOLI Escherichia coli (strain K12) # PATRIC 32116935 VBIEscCol129921_0893 # PIR H64824 H64824 # PIRSF PIRSF039085 ABC_ATPase_HisP # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # Pfam PF00005 ABC_tran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ARTP_ECOLI Arginine transport ATP-binding protein ArtP # RefSeq NP_415385 NC_000913.3 # RefSeq WP_000027205 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA # SUBCELLULAR LOCATION ARTP_ECOLI Cell inner membrane {ECO 0000305}; Peripheral membrane protein {ECO 0000305}. # SUBUNIT The complex is composed of two ATP-binding proteins (ArtP), two transmembrane proteins (ArtM and ArtQ) and two solute- binding proteins (ArtJ and ArtI). {ECO:0000305|PubMed 8801422}. # SUPFAM SSF52540 SSF52540 # TCDB 3.A.1.3 the atp-binding cassette (abc) superfamily # eggNOG COG4161 LUCA # eggNOG ENOG4105E5Z Bacteria BLAST swissprot:ARTP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARTP_ECOLI BioCyc ECOL316407:JW0848-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0848-MONOMER BioCyc EcoCyc:ARTP-MONOMER http://biocyc.org/getid?id=EcoCyc:ARTP-MONOMER BioCyc MetaCyc:ARTP-MONOMER http://biocyc.org/getid?id=MetaCyc:ARTP-MONOMER COG COG4161 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4161 DIP DIP-47917N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47917N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1995.mmi_17040675.x http://dx.doi.org/10.1111/j.1365-2958.1995.mmi_17040675.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.3.- http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X86160 http://www.ebi.ac.uk/ena/data/view/X86160 ENZYME 3.6.3.- http://enzyme.expasy.org/EC/3.6.3.- EchoBASE EB1581 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1581 EcoGene EG11624 http://www.ecogene.org/geneInfo.php?eg_id=EG11624 EnsemblBacteria AAC73951 http://www.ensemblgenomes.org/id/AAC73951 EnsemblBacteria AAC73951 http://www.ensemblgenomes.org/id/AAC73951 EnsemblBacteria BAA35578 http://www.ensemblgenomes.org/id/BAA35578 EnsemblBacteria BAA35578 http://www.ensemblgenomes.org/id/BAA35578 EnsemblBacteria BAA35578 http://www.ensemblgenomes.org/id/BAA35578 EnsemblBacteria b0864 http://www.ensemblgenomes.org/id/b0864 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0055052 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055052 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0015426 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015426 GO_process GO:1902765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902765 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945489 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945489 InParanoid P0AAF6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAF6 IntAct P0AAF6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAF6* IntEnz 3.6.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3 InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR030679 http://www.ebi.ac.uk/interpro/entry/IPR030679 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0848 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0848 KEGG_Gene eco:b0864 http://www.genome.jp/dbget-bin/www_bget?eco:b0864 KEGG_Orthology KO:K10000 http://www.genome.jp/dbget-bin/www_bget?KO:K10000 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 MINT MINT-1236053 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1236053 OMA MAIHYLR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MAIHYLR PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:ARTP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARTP_ECOLI PSORT-B swissprot:ARTP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARTP_ECOLI PSORT2 swissprot:ARTP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARTP_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Phobius swissprot:ARTP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARTP_ECOLI PhylomeDB P0AAF6 http://phylomedb.org/?seqid=P0AAF6 ProteinModelPortal P0AAF6 http://www.proteinmodelportal.org/query/uniprot/P0AAF6 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8501075 http://www.ncbi.nlm.nih.gov/pubmed/8501075 PubMed 8801422 http://www.ncbi.nlm.nih.gov/pubmed/8801422 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415385 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415385 RefSeq WP_000027205 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000027205 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P0AAF6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAF6 STRING 511145.b0864 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0864&targetmode=cogs STRING COG4161 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4161&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.3 http://www.tcdb.org/search/result.php?tc=3.A.1.3 UniProtKB ARTP_ECOLI http://www.uniprot.org/uniprot/ARTP_ECOLI UniProtKB-AC P0AAF6 http://www.uniprot.org/uniprot/P0AAF6 charge swissprot:ARTP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARTP_ECOLI eggNOG COG4161 http://eggnogapi.embl.de/nog_data/html/tree/COG4161 eggNOG ENOG4105E5Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E5Z epestfind swissprot:ARTP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARTP_ECOLI garnier swissprot:ARTP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARTP_ECOLI helixturnhelix swissprot:ARTP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARTP_ECOLI hmoment swissprot:ARTP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARTP_ECOLI iep swissprot:ARTP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARTP_ECOLI inforesidue swissprot:ARTP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARTP_ECOLI octanol swissprot:ARTP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARTP_ECOLI pepcoil swissprot:ARTP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARTP_ECOLI pepdigest swissprot:ARTP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARTP_ECOLI pepinfo swissprot:ARTP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARTP_ECOLI pepnet swissprot:ARTP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARTP_ECOLI pepstats swissprot:ARTP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARTP_ECOLI pepwheel swissprot:ARTP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARTP_ECOLI pepwindow swissprot:ARTP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARTP_ECOLI sigcleave swissprot:ARTP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARTP_ECOLI ## Database ID URL or Descriptions # BioGrid 4260020 9 # EcoGene EG13723 yccU # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0048037 cofactor binding; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # Gene3D 3.40.50.720 -; 1. # InterPro IPR003781 CoA-bd # InterPro IPR016040 NAD(P)-bd_dom # Organism YCCU_ECOLI Escherichia coli (strain K12) # PATRIC 32117151 VBIEscCol129921_1000 # PIR D64837 D64837 # Pfam PF13380 CoA_binding_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCCU_ECOLI Uncharacterized protein YccU # RefSeq NP_415485 NC_000913.3 # RefSeq WP_001301418 NZ_LN832404.1 # SMART SM00881 CoA_binding # SUPFAM SSF51735 SSF51735 # eggNOG COG1832 LUCA # eggNOG ENOG4105K4P Bacteria BLAST swissprot:YCCU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCCU_ECOLI BioCyc ECOL316407:JW5130-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5130-MONOMER BioCyc EcoCyc:G6499-MONOMER http://biocyc.org/getid?id=EcoCyc:G6499-MONOMER COG COG1832 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1832 DIP DIP-28069N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-28069N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1574-6968.1998.tb13343.x http://dx.doi.org/10.1111/j.1574-6968.1998.tb13343.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3487 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3487 EcoGene EG13723 http://www.ecogene.org/geneInfo.php?eg_id=EG13723 EnsemblBacteria AAC74051 http://www.ensemblgenomes.org/id/AAC74051 EnsemblBacteria AAC74051 http://www.ensemblgenomes.org/id/AAC74051 EnsemblBacteria BAA35730 http://www.ensemblgenomes.org/id/BAA35730 EnsemblBacteria BAA35730 http://www.ensemblgenomes.org/id/BAA35730 EnsemblBacteria BAA35730 http://www.ensemblgenomes.org/id/BAA35730 EnsemblBacteria b0965 http://www.ensemblgenomes.org/id/b0965 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0048037 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048037 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 949008 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949008 HOGENOM HOG000004470 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000004470&db=HOGENOM6 InParanoid P75874 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75874 IntAct P75874 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75874* InterPro IPR003781 http://www.ebi.ac.uk/interpro/entry/IPR003781 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 KEGG_Gene ecj:JW5130 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5130 KEGG_Gene eco:b0965 http://www.genome.jp/dbget-bin/www_bget?eco:b0965 KEGG_Orthology KO:K06929 http://www.genome.jp/dbget-bin/www_bget?KO:K06929 OMA IEYPRLI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IEYPRLI PSORT swissprot:YCCU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCCU_ECOLI PSORT-B swissprot:YCCU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCCU_ECOLI PSORT2 swissprot:YCCU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCCU_ECOLI Pfam PF13380 http://pfam.xfam.org/family/PF13380 Phobius swissprot:YCCU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCCU_ECOLI PhylomeDB P75874 http://phylomedb.org/?seqid=P75874 ProteinModelPortal P75874 http://www.proteinmodelportal.org/query/uniprot/P75874 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9868784 http://www.ncbi.nlm.nih.gov/pubmed/9868784 RefSeq NP_415485 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415485 RefSeq WP_001301418 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001301418 SMART SM00881 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00881 SMR P75874 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75874 STRING 511145.b0965 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0965&targetmode=cogs STRING COG1832 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1832&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB YCCU_ECOLI http://www.uniprot.org/uniprot/YCCU_ECOLI UniProtKB-AC P75874 http://www.uniprot.org/uniprot/P75874 charge swissprot:YCCU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCCU_ECOLI eggNOG COG1832 http://eggnogapi.embl.de/nog_data/html/tree/COG1832 eggNOG ENOG4105K4P http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K4P epestfind swissprot:YCCU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCCU_ECOLI garnier swissprot:YCCU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCCU_ECOLI helixturnhelix swissprot:YCCU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCCU_ECOLI hmoment swissprot:YCCU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCCU_ECOLI iep swissprot:YCCU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCCU_ECOLI inforesidue swissprot:YCCU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCCU_ECOLI octanol swissprot:YCCU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCCU_ECOLI pepcoil swissprot:YCCU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCCU_ECOLI pepdigest swissprot:YCCU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCCU_ECOLI pepinfo swissprot:YCCU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCCU_ECOLI pepnet swissprot:YCCU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCCU_ECOLI pepstats swissprot:YCCU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCCU_ECOLI pepwheel swissprot:YCCU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCCU_ECOLI pepwindow swissprot:YCCU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCCU_ECOLI sigcleave swissprot:YCCU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCCU_ECOLI ## Database ID URL or Descriptions # AltName PTV3B_ECOLI EIIBCA-Bgl # AltName PTV3B_ECOLI PTS system beta-glucoside-specific EIIA component # AltName PTV3B_ECOLI PTS system beta-glucoside-specific EIIB component # AltName PTV3B_ECOLI PTS system beta-glucoside-specific EIIB component # AltName PTV3B_ECOLI PTS system beta-glucoside-specific EIIC component # AltName PTV3B_ECOLI PTS system beta-glucoside-specific EIIC component # BioGrid 4262137 5 # CATALYTIC ACTIVITY Protein EIIA N(pi)-phospho-L-histidine + protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L- histidine/cysteine. {ECO:0000255|PROSITE-ProRule PRU00416}. # CATALYTIC ACTIVITY Protein EIIB N(pi)-phospho-L- histidine/cysteine + sugar = protein EIIB + sugar phosphate. {ECO:0000255|PROSITE-ProRule PRU00421}. # CDD cd00212 PTS_IIB_glc # DOMAIN PTV3B_ECOLI The EIIA domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the EIIB domain. # DOMAIN PTV3B_ECOLI The EIIB domain is phosphorylated by phospho-EIIA on a cysteinyl or histidyl residue, depending on the transported sugar. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the EIIC domain. # DOMAIN PTV3B_ECOLI The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site. # EcoGene EG10115 bglF # FUNCTION PTV3B_ECOLI Acts as both a kinase and a phosphatase on BglG. # FUNCTION PTV3B_ECOLI The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in beta-glucoside transport. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0008982 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:InterPro. # GO_function GO:0016301 kinase activity; IEA:UniProtKB-KW. # GO_function GO:0090563 protein-phosphocysteine-sugar phosphotransferase activity; IBA:GO_Central. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IBA:GO_Central. # GO_process GO:0034219 carbohydrate transmembrane transport; IBA:GO_Central. # GO_process GO:0043610 regulation of carbohydrate utilization; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # GOslim_process GO:0055085 transmembrane transport # Gene3D 3.30.1360.60 -; 1. # InterPro IPR001127 PTS_EIIA_1_perm # InterPro IPR001996 PTS_IIB_1 # InterPro IPR003352 PTS_EIIC # InterPro IPR004719 PTS_maltose/Glc_sub_IIC # InterPro IPR011055 Dup_hybrid_motif # InterPro IPR011297 PTS_IIABC_b_glu # InterPro IPR013013 PTS_EIIC_1 # InterPro IPR018113 PTrfase_EIIB_Cys # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00271 PTS system, beta-glucosides-specific II component # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02060 Phosphotransferase system (PTS) # Organism PTV3B_ECOLI Escherichia coli (strain K12) # PATRIC 32122939 VBIEscCol129921_3845 # PIR C25977 C25977 # PROSITE PS00371 PTS_EIIA_TYPE_1_HIS # PROSITE PS01035 PTS_EIIB_TYPE_1_CYS # PROSITE PS51093 PTS_EIIA_TYPE_1 # PROSITE PS51098 PTS_EIIB_TYPE_1 # PROSITE PS51103 PTS_EIIC_TYPE_1 # Pfam PF00358 PTS_EIIA_1 # Pfam PF00367 PTS_EIIB # Pfam PF02378 PTS_EIIC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PTV3B_ECOLI Beta-glucoside permease IIC component # RecName PTV3B_ECOLI Beta-glucoside-specific phosphotransferase enzyme IIA component # RecName PTV3B_ECOLI Beta-glucoside-specific phosphotransferase enzyme IIB component # RecName PTV3B_ECOLI PTS system beta-glucoside-specific EIIBCA component # RefSeq NP_418178 NC_000913.3 # RefSeq WP_000137296 NZ_LN832404.1 # SIMILARITY Contains 1 PTS EIIA type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00416}. # SIMILARITY Contains 1 PTS EIIB type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00421}. # SIMILARITY Contains 1 PTS EIIC type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00426}. # SUBCELLULAR LOCATION PTV3B_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF51261 SSF51261 # SUPFAM SSF55604 SSF55604 # TCDB 4.A.1.2 the pts glucose-glucoside (glc) family # TIGRFAMs TIGR00826 EIIB_glc # TIGRFAMs TIGR00830 PTBA # TIGRFAMs TIGR00852 pts-Glc # TIGRFAMs TIGR01995 PTS-II-ABC-beta # eggNOG COG1263 LUCA # eggNOG COG1264 LUCA # eggNOG COG2190 LUCA # eggNOG ENOG4105C5Y Bacteria BLAST swissprot:PTV3B_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTV3B_ECOLI BioCyc ECOL316407:JW3700-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3700-MONOMER BioCyc EcoCyc:BGLF-MONOMER http://biocyc.org/getid?id=EcoCyc:BGLF-MONOMER BioCyc MetaCyc:BGLF-MONOMER http://biocyc.org/getid?id=MetaCyc:BGLF-MONOMER COG COG1263 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1263 DIP DIP-9215N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9215N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1099/00221287-133-3-563 http://dx.doi.org/10.1099/00221287-133-3-563 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M15746 http://www.ebi.ac.uk/ena/data/view/M15746 EMBL M16487 http://www.ebi.ac.uk/ena/data/view/M16487 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.- http://enzyme.expasy.org/EC/2.7.1.- EchoBASE EB0113 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0113 EcoGene EG10115 http://www.ecogene.org/geneInfo.php?eg_id=EG10115 EnsemblBacteria AAC76745 http://www.ensemblgenomes.org/id/AAC76745 EnsemblBacteria AAC76745 http://www.ensemblgenomes.org/id/AAC76745 EnsemblBacteria BAE77566 http://www.ensemblgenomes.org/id/BAE77566 EnsemblBacteria BAE77566 http://www.ensemblgenomes.org/id/BAE77566 EnsemblBacteria BAE77566 http://www.ensemblgenomes.org/id/BAE77566 EnsemblBacteria b3722 http://www.ensemblgenomes.org/id/b3722 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008982 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008982 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_function GO:0090563 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090563 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GO_process GO:0034219 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034219 GO_process GO:0043610 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043610 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 3.30.1360.60 http://www.cathdb.info/version/latest/superfamily/3.30.1360.60 GeneID 948236 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948236 HOGENOM HOG000102023 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000102023&db=HOGENOM6 InParanoid P08722 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P08722 IntAct P08722 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P08722* IntEnz 2.7.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1 InterPro IPR001127 http://www.ebi.ac.uk/interpro/entry/IPR001127 InterPro IPR001996 http://www.ebi.ac.uk/interpro/entry/IPR001996 InterPro IPR003352 http://www.ebi.ac.uk/interpro/entry/IPR003352 InterPro IPR004719 http://www.ebi.ac.uk/interpro/entry/IPR004719 InterPro IPR011055 http://www.ebi.ac.uk/interpro/entry/IPR011055 InterPro IPR011297 http://www.ebi.ac.uk/interpro/entry/IPR011297 InterPro IPR013013 http://www.ebi.ac.uk/interpro/entry/IPR013013 InterPro IPR018113 http://www.ebi.ac.uk/interpro/entry/IPR018113 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3700 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3700 KEGG_Gene eco:b3722 http://www.genome.jp/dbget-bin/www_bget?eco:b3722 KEGG_Orthology KO:K02757 http://www.genome.jp/dbget-bin/www_bget?KO:K02757 KEGG_Pathway ko02060 http://www.genome.jp/kegg-bin/show_pathway?ko02060 OMA KIWFAAS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KIWFAAS PROSITE PS00371 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00371 PROSITE PS01035 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01035 PROSITE PS51093 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51093 PROSITE PS51098 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51098 PROSITE PS51103 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51103 PSORT swissprot:PTV3B_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTV3B_ECOLI PSORT-B swissprot:PTV3B_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTV3B_ECOLI PSORT2 swissprot:PTV3B_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTV3B_ECOLI Pfam PF00358 http://pfam.xfam.org/family/PF00358 Pfam PF00367 http://pfam.xfam.org/family/PF00367 Pfam PF02378 http://pfam.xfam.org/family/PF02378 Phobius swissprot:PTV3B_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTV3B_ECOLI PhylomeDB P08722 http://phylomedb.org/?seqid=P08722 ProteinModelPortal P08722 http://www.proteinmodelportal.org/query/uniprot/P08722 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3034860 http://www.ncbi.nlm.nih.gov/pubmed/3034860 PubMed 3309161 http://www.ncbi.nlm.nih.gov/pubmed/3309161 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418178 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418178 RefSeq WP_000137296 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000137296 STRING 511145.b3722 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3722&targetmode=cogs STRING COG1263 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1263&targetmode=cogs SUPFAM SSF51261 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51261 SUPFAM SSF55604 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55604 TCDB 4.A.1.2 http://www.tcdb.org/search/result.php?tc=4.A.1.2 TIGRFAMs TIGR00826 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00826 TIGRFAMs TIGR00830 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00830 TIGRFAMs TIGR00852 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00852 TIGRFAMs TIGR01995 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01995 UniProtKB PTV3B_ECOLI http://www.uniprot.org/uniprot/PTV3B_ECOLI UniProtKB-AC P08722 http://www.uniprot.org/uniprot/P08722 charge swissprot:PTV3B_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTV3B_ECOLI eggNOG COG1263 http://eggnogapi.embl.de/nog_data/html/tree/COG1263 eggNOG COG1264 http://eggnogapi.embl.de/nog_data/html/tree/COG1264 eggNOG COG2190 http://eggnogapi.embl.de/nog_data/html/tree/COG2190 eggNOG ENOG4105C5Y http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C5Y epestfind swissprot:PTV3B_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTV3B_ECOLI garnier swissprot:PTV3B_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTV3B_ECOLI helixturnhelix swissprot:PTV3B_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTV3B_ECOLI hmoment swissprot:PTV3B_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTV3B_ECOLI iep swissprot:PTV3B_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTV3B_ECOLI inforesidue swissprot:PTV3B_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTV3B_ECOLI octanol swissprot:PTV3B_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTV3B_ECOLI pepcoil swissprot:PTV3B_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTV3B_ECOLI pepdigest swissprot:PTV3B_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTV3B_ECOLI pepinfo swissprot:PTV3B_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTV3B_ECOLI pepnet swissprot:PTV3B_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTV3B_ECOLI pepstats swissprot:PTV3B_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTV3B_ECOLI pepwheel swissprot:PTV3B_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTV3B_ECOLI pepwindow swissprot:PTV3B_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTV3B_ECOLI sigcleave swissprot:PTV3B_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTV3B_ECOLI ## Database ID URL or Descriptions # BioGrid 4259605 5 # CATALYTIC ACTIVITY ADHE_ECOLI Acetaldehyde + CoA + NAD(+) = acetyl-CoA + NADH. # CATALYTIC ACTIVITY ADHE_ECOLI An alcohol + NAD(+) = an aldehyde or ketone + NADH. # COFACTOR Name=Fe cation; Xref=ChEBI:CHEBI 24875; # EcoGene EG10031 adhE # FUNCTION ADHE_ECOLI This enzyme has three activities ADH, ACDH, and PFL- deactivase. In aerobic conditions it acts as a hydrogen peroxide scavenger. The PFL deactivase activity catalyzes the quenching of the pyruvate-formate-lyase catalyst in an iron, NAD, and CoA dependent reaction. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0004022 alcohol dehydrogenase (NAD) activity; IMP:EcoliWiki. # GO_function GO:0008774 acetaldehyde dehydrogenase (acetylating) activity; IMP:EcoliWiki. # GO_function GO:0046872 metal ion binding; IEA:InterPro. # GO_process GO:0006115 ethanol biosynthetic process; IDA:EcoliWiki. # GO_process GO:0015976 carbon utilization; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.309.10 -; 2. # Gene3D 3.40.605.10 -; 1. # INDUCTION ADHE_ECOLI Under anaerobic conditions in the absence of nitrate. # INTERACTION ADHE_ECOLI Self; NbExp=2; IntAct=EBI-543417, EBI-543417; # IntAct P0A9Q7 18 # InterPro IPR001670 ADH_Fe # InterPro IPR012079 Bifunc_Ald-ADH # InterPro IPR015590 Aldehyde_DH_dom # InterPro IPR016161 Ald_DH/histidinol_DH # InterPro IPR016162 Ald_DH_N # InterPro IPR016163 Ald_DH_C # InterPro IPR018211 ADH_Fe_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00010 Glycolysis / Gluconeogenesis # KEGG_Pathway ko00071 Fatty acid metabolism # KEGG_Pathway ko00350 Tyrosine metabolism # KEGG_Pathway ko00362 Benzoate degradation # KEGG_Pathway ko00620 Pyruvate metabolism # KEGG_Pathway ko00621 Dioxin degradation # KEGG_Pathway ko00622 Xylene degradation # KEGG_Pathway ko00625 Chloroalkane and chloroalkene degradation # KEGG_Pathway ko00626 Naphthalene degradation # KEGG_Pathway ko00650 Butanoate metabolism # Organism ADHE_ECOLI Escherichia coli (strain K12) # PATRIC 32117740 VBIEscCol129921_1290 # PIR JS0406 DEEC # PIRSF PIRSF000111 ALDH_ADH # PROSITE PS00060 ADH_IRON_2 # PROSITE PS00913 ADH_IRON_1 # Pfam PF00171 Aldedh # Pfam PF00465 Fe-ADH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ADHE_ECOLI Acetaldehyde dehydrogenase [acetylating] # RecName ADHE_ECOLI Alcohol dehydrogenase # RecName ADHE_ECOLI Aldehyde-alcohol dehydrogenase # RecName ADHE_ECOLI Aldehyde-alcohol dehydrogenase # RecName ADHE_ECOLI Pyruvate-formate-lyase deactivase # RefSeq NP_415757 NC_000913.3 # RefSeq WP_000301651 NZ_LN832404.1 # SIMILARITY In the C-terminal section; belongs to the iron- containing alcohol dehydrogenase family. {ECO 0000305}. # SIMILARITY In the N-terminal section; belongs to the aldehyde dehydrogenase family. {ECO 0000305}. # SUBUNIT ADHE_ECOLI Seems to form a rod shaped polymer composed of about 40 identical subunits. # SUPFAM SSF53720 SSF53720 # eggNOG COG1012 LUCA # eggNOG COG1454 LUCA # eggNOG ENOG4105C0A Bacteria BLAST swissprot:ADHE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ADHE_ECOLI BioCyc ECOL316407:JW1228-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1228-MONOMER BioCyc EcoCyc:ADHE-MONOMER http://biocyc.org/getid?id=EcoCyc:ADHE-MONOMER BioCyc MetaCyc:ADHE-MONOMER http://biocyc.org/getid?id=MetaCyc:ADHE-MONOMER COG COG1012 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1012 DIP DIP-35790N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35790N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0014-5793(91)80358-A http://dx.doi.org/10.1016/0014-5793(91)80358-A DOI 10.1016/0378-1119(89)90483-6 http://dx.doi.org/10.1016/0378-1119(89)90483-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M304351200 http://dx.doi.org/10.1074/jbc.M304351200 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1099/13500872-141-4-959 http://dx.doi.org/10.1099/13500872-141-4-959 DOI 10.1111/j.1348-0421.1994.tb01762.x http://dx.doi.org/10.1111/j.1348-0421.1994.tb01762.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.1 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.1 EC_number EC:1.2.1.10 http://www.genome.jp/dbget-bin/www_bget?EC:1.2.1.10 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M33504 http://www.ebi.ac.uk/ena/data/view/M33504 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X59263 http://www.ebi.ac.uk/ena/data/view/X59263 EMBL X67326 http://www.ebi.ac.uk/ena/data/view/X67326 ENZYME 1.1.1.1 http://enzyme.expasy.org/EC/1.1.1.1 ENZYME 1.2.1.10 http://enzyme.expasy.org/EC/1.2.1.10 EchoBASE EB0030 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0030 EcoGene EG10031 http://www.ecogene.org/geneInfo.php?eg_id=EG10031 EnsemblBacteria AAC74323 http://www.ensemblgenomes.org/id/AAC74323 EnsemblBacteria AAC74323 http://www.ensemblgenomes.org/id/AAC74323 EnsemblBacteria BAA36121 http://www.ensemblgenomes.org/id/BAA36121 EnsemblBacteria BAA36121 http://www.ensemblgenomes.org/id/BAA36121 EnsemblBacteria BAA36121 http://www.ensemblgenomes.org/id/BAA36121 EnsemblBacteria b1241 http://www.ensemblgenomes.org/id/b1241 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0004022 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004022 GO_function GO:0008774 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008774 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006115 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006115 GO_process GO:0015976 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015976 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.309.10 http://www.cathdb.info/version/latest/superfamily/3.40.309.10 Gene3D 3.40.605.10 http://www.cathdb.info/version/latest/superfamily/3.40.605.10 GeneID 945837 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945837 HOGENOM HOG000025256 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000025256&db=HOGENOM6 InParanoid P0A9Q7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9Q7 IntAct P0A9Q7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9Q7* IntEnz 1.1.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.1 IntEnz 1.2.1.10 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.2.1.10 InterPro IPR001670 http://www.ebi.ac.uk/interpro/entry/IPR001670 InterPro IPR012079 http://www.ebi.ac.uk/interpro/entry/IPR012079 InterPro IPR015590 http://www.ebi.ac.uk/interpro/entry/IPR015590 InterPro IPR016161 http://www.ebi.ac.uk/interpro/entry/IPR016161 InterPro IPR016162 http://www.ebi.ac.uk/interpro/entry/IPR016162 InterPro IPR016163 http://www.ebi.ac.uk/interpro/entry/IPR016163 InterPro IPR018211 http://www.ebi.ac.uk/interpro/entry/IPR018211 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1228 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1228 KEGG_Gene eco:b1241 http://www.genome.jp/dbget-bin/www_bget?eco:b1241 KEGG_Orthology KO:K04072 http://www.genome.jp/dbget-bin/www_bget?KO:K04072 KEGG_Pathway ko00010 http://www.genome.jp/kegg-bin/show_pathway?ko00010 KEGG_Pathway ko00071 http://www.genome.jp/kegg-bin/show_pathway?ko00071 KEGG_Pathway ko00350 http://www.genome.jp/kegg-bin/show_pathway?ko00350 KEGG_Pathway ko00362 http://www.genome.jp/kegg-bin/show_pathway?ko00362 KEGG_Pathway ko00620 http://www.genome.jp/kegg-bin/show_pathway?ko00620 KEGG_Pathway ko00621 http://www.genome.jp/kegg-bin/show_pathway?ko00621 KEGG_Pathway ko00622 http://www.genome.jp/kegg-bin/show_pathway?ko00622 KEGG_Pathway ko00625 http://www.genome.jp/kegg-bin/show_pathway?ko00625 KEGG_Pathway ko00626 http://www.genome.jp/kegg-bin/show_pathway?ko00626 KEGG_Pathway ko00650 http://www.genome.jp/kegg-bin/show_pathway?ko00650 KEGG_Reaction rn:R00228 http://www.genome.jp/dbget-bin/www_bget?rn:R00228 KEGG_Reaction rn:R00623 http://www.genome.jp/dbget-bin/www_bget?rn:R00623 KEGG_Reaction rn:R00754 http://www.genome.jp/dbget-bin/www_bget?rn:R00754 KEGG_Reaction rn:R01172 http://www.genome.jp/dbget-bin/www_bget?rn:R01172 KEGG_Reaction rn:R04880 http://www.genome.jp/dbget-bin/www_bget?rn:R04880 KEGG_Reaction rn:R05233 http://www.genome.jp/dbget-bin/www_bget?rn:R05233 KEGG_Reaction rn:R05234 http://www.genome.jp/dbget-bin/www_bget?rn:R05234 KEGG_Reaction rn:R06917 http://www.genome.jp/dbget-bin/www_bget?rn:R06917 KEGG_Reaction rn:R06927 http://www.genome.jp/dbget-bin/www_bget?rn:R06927 MINT MINT-1288364 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1288364 OMA FYEVEAD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FYEVEAD PROSITE PS00060 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00060 PROSITE PS00913 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00913 PSORT swissprot:ADHE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ADHE_ECOLI PSORT-B swissprot:ADHE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ADHE_ECOLI PSORT2 swissprot:ADHE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ADHE_ECOLI Pfam PF00171 http://pfam.xfam.org/family/PF00171 Pfam PF00465 http://pfam.xfam.org/family/PF00465 Phobius swissprot:ADHE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ADHE_ECOLI PhylomeDB P0A9Q7 http://phylomedb.org/?seqid=P0A9Q7 ProteinModelPortal P0A9Q7 http://www.proteinmodelportal.org/query/uniprot/P0A9Q7 PubMed 12783863 http://www.ncbi.nlm.nih.gov/pubmed/12783863 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 2015910 http://www.ncbi.nlm.nih.gov/pubmed/2015910 PubMed 2695398 http://www.ncbi.nlm.nih.gov/pubmed/2695398 PubMed 7521508 http://www.ncbi.nlm.nih.gov/pubmed/7521508 PubMed 7773397 http://www.ncbi.nlm.nih.gov/pubmed/7773397 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_415757 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415757 RefSeq WP_000301651 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000301651 SMR P0A9Q7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9Q7 STRING 511145.b1241 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1241&targetmode=cogs STRING COG1012 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1012&targetmode=cogs SUPFAM SSF53720 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53720 UniProtKB ADHE_ECOLI http://www.uniprot.org/uniprot/ADHE_ECOLI UniProtKB-AC P0A9Q7 http://www.uniprot.org/uniprot/P0A9Q7 charge swissprot:ADHE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ADHE_ECOLI eggNOG COG1012 http://eggnogapi.embl.de/nog_data/html/tree/COG1012 eggNOG COG1454 http://eggnogapi.embl.de/nog_data/html/tree/COG1454 eggNOG ENOG4105C0A http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C0A epestfind swissprot:ADHE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ADHE_ECOLI garnier swissprot:ADHE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ADHE_ECOLI helixturnhelix swissprot:ADHE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ADHE_ECOLI hmoment swissprot:ADHE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ADHE_ECOLI iep swissprot:ADHE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ADHE_ECOLI inforesidue swissprot:ADHE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ADHE_ECOLI octanol swissprot:ADHE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ADHE_ECOLI pepcoil swissprot:ADHE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ADHE_ECOLI pepdigest swissprot:ADHE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ADHE_ECOLI pepinfo swissprot:ADHE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ADHE_ECOLI pepnet swissprot:ADHE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ADHE_ECOLI pepstats swissprot:ADHE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ADHE_ECOLI pepwheel swissprot:ADHE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ADHE_ECOLI pepwindow swissprot:ADHE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ADHE_ECOLI sigcleave swissprot:ADHE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ADHE_ECOLI ## Database ID URL or Descriptions # BioGrid 4260480 437 # CAUTION Could be the product of a pseudogene. The original sequence is interrupted between codons 21 and 22 by a IS5K insertion element. {ECO 0000305}. # EcoGene EG12051 yejO # GO_component GO:0009279 cell outer membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0007155 cell adhesion; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0007155 cell adhesion # Gene3D 2.160.20.20 -; 1. # Gene3D 2.40.128.130 -; 1. # InterPro IPR003991 Pertactin_virulence_factor # InterPro IPR004899 Pertactin_central # InterPro IPR005546 Autotransporte_beta # InterPro IPR006315 OM_autotransptr_brl # InterPro IPR011050 Pectin_lyase_fold/virulence # InterPro IPR012332 P22_tailspike_C-like # InterPro IPR030930 AIDA # Organism YEJO_ECOLI Escherichia coli (strain K12) # PATRIC 48663755 VBIEscCol107702_2220 # PIR D64988 D64988 # PRINTS PR01484 PRTACTNFAMLY # PROSITE PS51208 AUTOTRANSPORTER # Pfam PF03212 Pertactin # Pfam PF03797 Autotransporter # Pfam PF16168 AIDA; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEJO_ECOLI Putative uncharacterized outer membrane protein YejO # SIMILARITY Contains 1 autotransporter (TC 1.B.12) domain. {ECO:0000255|PROSITE-ProRule PRU00556}. # SMART SM00869 Autotransporter # SUBCELLULAR LOCATION YEJO_ECOLI Cell outer membrane {ECO 0000305}; Peripheral membrane protein {ECO 0000305}. # SUPFAM SSF103515 SSF103515 # SUPFAM SSF51126 SSF51126 # TIGRFAMs TIGR01414 autotrans_barl # TIGRFAMs TIGR04415 O_hepto_targRPT; 3 # eggNOG ENOG4108MGN Bacteria # eggNOG ENOG4110GG4 LUCA BLAST swissprot:YEJO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEJO_ECOLI BioCyc ECOL316407:JW5839-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5839-MONOMER BioCyc EcoCyc:EG12051-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12051-MONOMER DIP DIP-11942N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11942N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00008 http://www.ebi.ac.uk/ena/data/view/U00008 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1982 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1982 EcoGene EG12051 http://www.ecogene.org/geneInfo.php?eg_id=EG12051 EnsemblBacteria BAE76654 http://www.ensemblgenomes.org/id/BAE76654 EnsemblBacteria BAE76654 http://www.ensemblgenomes.org/id/BAE76654 EnsemblBacteria BAE76654 http://www.ensemblgenomes.org/id/BAE76654 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 Gene3D 2.160.20.20 http://www.cathdb.info/version/latest/superfamily/2.160.20.20 Gene3D 2.40.128.130 http://www.cathdb.info/version/latest/superfamily/2.40.128.130 HOGENOM HOG000009752 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009752&db=HOGENOM6 InParanoid P33924 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33924 IntAct P33924 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33924* InterPro IPR003991 http://www.ebi.ac.uk/interpro/entry/IPR003991 InterPro IPR004899 http://www.ebi.ac.uk/interpro/entry/IPR004899 InterPro IPR005546 http://www.ebi.ac.uk/interpro/entry/IPR005546 InterPro IPR006315 http://www.ebi.ac.uk/interpro/entry/IPR006315 InterPro IPR011050 http://www.ebi.ac.uk/interpro/entry/IPR011050 InterPro IPR012332 http://www.ebi.ac.uk/interpro/entry/IPR012332 InterPro IPR030930 http://www.ebi.ac.uk/interpro/entry/IPR030930 KEGG_Gene ecj:JW5839 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5839 MINT MINT-1322746 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1322746 PRINTS PR01484 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01484 PROSITE PS51208 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51208 PSORT swissprot:YEJO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEJO_ECOLI PSORT-B swissprot:YEJO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEJO_ECOLI PSORT2 swissprot:YEJO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEJO_ECOLI Pfam PF03212 http://pfam.xfam.org/family/PF03212 Pfam PF03797 http://pfam.xfam.org/family/PF03797 Pfam PF16168 http://pfam.xfam.org/family/PF16168 Phobius swissprot:YEJO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEJO_ECOLI PhylomeDB P33924 http://phylomedb.org/?seqid=P33924 ProteinModelPortal P33924 http://www.proteinmodelportal.org/query/uniprot/P33924 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SMART SM00869 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00869 STRING 316407.85675298 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85675298&targetmode=cogs SUPFAM SSF103515 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103515 SUPFAM SSF51126 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51126 TIGRFAMs TIGR01414 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01414 TIGRFAMs TIGR04415 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR04415 UniProtKB YEJO_ECOLI http://www.uniprot.org/uniprot/YEJO_ECOLI UniProtKB-AC P33924 http://www.uniprot.org/uniprot/P33924 charge swissprot:YEJO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEJO_ECOLI eggNOG ENOG4108MGN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MGN eggNOG ENOG4110GG4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4110GG4 epestfind swissprot:YEJO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEJO_ECOLI garnier swissprot:YEJO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEJO_ECOLI helixturnhelix swissprot:YEJO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEJO_ECOLI hmoment swissprot:YEJO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEJO_ECOLI iep swissprot:YEJO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEJO_ECOLI inforesidue swissprot:YEJO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEJO_ECOLI octanol swissprot:YEJO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEJO_ECOLI pepcoil swissprot:YEJO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEJO_ECOLI pepdigest swissprot:YEJO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEJO_ECOLI pepinfo swissprot:YEJO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEJO_ECOLI pepnet swissprot:YEJO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEJO_ECOLI pepstats swissprot:YEJO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEJO_ECOLI pepwheel swissprot:YEJO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEJO_ECOLI pepwindow swissprot:YEJO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEJO_ECOLI sigcleave swissprot:YEJO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEJO_ECOLI ## Database ID URL or Descriptions # AltName FUCP_ECOLI 6-deoxy-L-galactose permease # AltName FUCP_ECOLI L-fucose permease # BioGrid 4260704 18 # CDD cd06174 MFS # EcoGene EG10352 fucP # FUNCTION FUCP_ECOLI Mediates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Can also transport L-galactose and D-arabinose, but at reduced rates compared with L-fucose. Is not able to transport L-rhamnose and L-arabinose. {ECO 0000269|PubMed 2829831}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_component GO:0016021 integral component of membrane; IDA:EcoCyc. # GO_function FUCP_ECOLI GO 0015517 galactose proton symporter activity; IDA EcoCyc. # GO_function FUCP_ECOLI GO 0015518 arabinose proton symporter activity; IDA EcoCyc. # GO_function FUCP_ECOLI GO 0015535 fucose proton symporter activity; IMP EcoCyc. # GO_process GO:0006004 fucose metabolic process; IEA:UniProtKB-KW. # GO_process GO:0015751 arabinose transport; IDA:EcoCyc. # GO_process GO:0015756 fucose transport; IMP:EcoCyc. # GO_process GO:0015757 galactose transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006810 transport # GOslim_process GO:0044281 small molecule metabolic process # INDUCTION By L-fucose. {ECO:0000269|PubMed 2829831}. # InterPro IPR005275 Lfuc_permease_FucP # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # KEGG_Brite ko02000 Transporters # Organism FUCP_ECOLI Escherichia coli (strain K12) # PATRIC 32121018 VBIEscCol129921_2901 # PDB 3O7P X-ray; 3.20 A; A=1-438 # PDB 3O7Q X-ray; 3.14 A; A=1-438 # PIR JS0184 WQECFP # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FUCP_ECOLI L-fucose-proton symporter # RefSeq NP_417281 NC_000913.3 # RefSeq WP_000528603 NZ_LN832404.1 # SIMILARITY Belongs to the major facilitator superfamily. FHS transporter (TC 2.A.1.7) family. {ECO 0000305}. # SUBCELLULAR LOCATION FUCP_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.7 the major facilitator superfamily (mfs) # TIGRFAMs TIGR00885 fucP # eggNOG COG0738 LUCA # eggNOG ENOG4105EDR Bacteria BLAST swissprot:FUCP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FUCP_ECOLI BioCyc ECOL316407:JW2772-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2772-MONOMER BioCyc EcoCyc:FUCP-MONOMER http://biocyc.org/getid?id=EcoCyc:FUCP-MONOMER BioCyc MetaCyc:FUCP-MONOMER http://biocyc.org/getid?id=MetaCyc:FUCP-MONOMER COG COG0738 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0738 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2480495 http://dx.doi.org/10.1042/bj2480495 DOI 10.1093/nar/17.12.4883 http://dx.doi.org/10.1093/nar/17.12.4883 DOI 10.1111/j.1365-2958.1994.tb01066.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb01066.x DOI 10.1111/j.1365-2958.1995.tb02384.x http://dx.doi.org/10.1111/j.1365-2958.1995.tb02384.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M31059 http://www.ebi.ac.uk/ena/data/view/M31059 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 EMBL X15025 http://www.ebi.ac.uk/ena/data/view/X15025 EchoBASE EB0348 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0348 EcoGene EG10352 http://www.ecogene.org/geneInfo.php?eg_id=EG10352 EnsemblBacteria AAC75843 http://www.ensemblgenomes.org/id/AAC75843 EnsemblBacteria AAC75843 http://www.ensemblgenomes.org/id/AAC75843 EnsemblBacteria BAE76873 http://www.ensemblgenomes.org/id/BAE76873 EnsemblBacteria BAE76873 http://www.ensemblgenomes.org/id/BAE76873 EnsemblBacteria BAE76873 http://www.ensemblgenomes.org/id/BAE76873 EnsemblBacteria b2801 http://www.ensemblgenomes.org/id/b2801 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015517 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015517 GO_function GO:0015518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015518 GO_function GO:0015535 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015535 GO_process GO:0006004 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006004 GO_process GO:0015751 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015751 GO_process GO:0015756 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015756 GO_process GO:0015757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015757 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 947487 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947487 HOGENOM HOG000267862 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267862&db=HOGENOM6 InParanoid P11551 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P11551 InterPro IPR005275 http://www.ebi.ac.uk/interpro/entry/IPR005275 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2772 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2772 KEGG_Gene eco:b2801 http://www.genome.jp/dbget-bin/www_bget?eco:b2801 KEGG_Orthology KO:K02429 http://www.genome.jp/dbget-bin/www_bget?KO:K02429 OMA FESCIFP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FESCIFP PDB 3O7P http://www.ebi.ac.uk/pdbe-srv/view/entry/3O7P PDB 3O7Q http://www.ebi.ac.uk/pdbe-srv/view/entry/3O7Q PDBsum 3O7P http://www.ebi.ac.uk/pdbsum/3O7P PDBsum 3O7Q http://www.ebi.ac.uk/pdbsum/3O7Q PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:FUCP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FUCP_ECOLI PSORT-B swissprot:FUCP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FUCP_ECOLI PSORT2 swissprot:FUCP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FUCP_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:FUCP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FUCP_ECOLI PhylomeDB P11551 http://phylomedb.org/?seqid=P11551 ProteinModelPortal P11551 http://www.proteinmodelportal.org/query/uniprot/P11551 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2553671 http://www.ncbi.nlm.nih.gov/pubmed/2553671 PubMed 2664711 http://www.ncbi.nlm.nih.gov/pubmed/2664711 PubMed 2829831 http://www.ncbi.nlm.nih.gov/pubmed/2829831 PubMed 7783647 http://www.ncbi.nlm.nih.gov/pubmed/7783647 PubMed 8052131 http://www.ncbi.nlm.nih.gov/pubmed/8052131 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417281 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417281 RefSeq WP_000528603 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000528603 SMR P11551 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P11551 STRING 511145.b2801 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2801&targetmode=cogs STRING COG0738 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0738&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.7 http://www.tcdb.org/search/result.php?tc=2.A.1.7 TIGRFAMs TIGR00885 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00885 UniProtKB FUCP_ECOLI http://www.uniprot.org/uniprot/FUCP_ECOLI UniProtKB-AC P11551 http://www.uniprot.org/uniprot/P11551 charge swissprot:FUCP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FUCP_ECOLI eggNOG COG0738 http://eggnogapi.embl.de/nog_data/html/tree/COG0738 eggNOG ENOG4105EDR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EDR epestfind swissprot:FUCP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FUCP_ECOLI garnier swissprot:FUCP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FUCP_ECOLI helixturnhelix swissprot:FUCP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FUCP_ECOLI hmoment swissprot:FUCP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FUCP_ECOLI iep swissprot:FUCP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FUCP_ECOLI inforesidue swissprot:FUCP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FUCP_ECOLI octanol swissprot:FUCP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FUCP_ECOLI pepcoil swissprot:FUCP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FUCP_ECOLI pepdigest swissprot:FUCP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FUCP_ECOLI pepinfo swissprot:FUCP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FUCP_ECOLI pepnet swissprot:FUCP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FUCP_ECOLI pepstats swissprot:FUCP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FUCP_ECOLI pepwheel swissprot:FUCP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FUCP_ECOLI pepwindow swissprot:FUCP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FUCP_ECOLI sigcleave swissprot:FUCP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FUCP_ECOLI ## Database ID URL or Descriptions # AltName FDNH_ECOLI Anaerobic formate dehydrogenase iron-sulfur subunit # AltName FDNH_ECOLI Formate dehydrogenase-N subunit beta # BRENDA 1.1.5 2026 # BioGrid 4262901 8 # COFACTOR FDNH_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000269|PubMed 11884747}; Note=Binds 4 [4Fe-4S] clusters per subunit. {ECO 0000269|PubMed 11884747}; # EcoGene EG11228 fdnH # FUNCTION FDNH_ECOLI Formate dehydrogenase allows E.coli to use formate as major electron donor during anaerobic respiration, when nitrate is used as electron acceptor. The beta subunit FdnH is an electron transfer unit containing 4 iron-sulfur clusters; it serves as a conduit for electrons that are transferred from the formate oxidation site in the alpha subunit (FdnG) to the menaquinone associated with the gamma subunit (FdnI) of formate dehydrogenase- N. Formate dehydrogenase-N is part of a system that generates proton motive force, together with the dissimilatory nitrate reductase (Nar). {ECO 0000269|PubMed 11884747}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_component GO:0009326 formate dehydrogenase complex; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_component GO:0071575 integral component of external side of plasma membrane; IDA:EcoCyc. # GO_function GO:0009055 electron carrier activity; IDA:EcoCyc. # GO_function GO:0036397 formate dehydrogenase (quinone) activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IDA:EcoCyc. # GO_process GO:0009061 anaerobic respiration; IEP:EcoCyc. # GO_process GO:0015944 formate oxidation; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0044281 small molecule metabolic process # INDUCTION By nitrate under anaerobic conditions. {ECO:0000269|PubMed 2168848}. # IntAct P0AAJ3 18 # InterPro IPR006470 Formate_DH_bsu_Proteobacteria # InterPro IPR014603 Formate_DH_Fe-S_su # InterPro IPR015246 Formate_DH_TM # InterPro IPR017896 4Fe4S_Fe-S-bd # InterPro IPR017900 4Fe4S_Fe_S_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Pathway ko00630 Glyoxylate and dicarboxylate metabolism # KEGG_Pathway ko00680 Methane metabolism # KEGG_Pathway ko02020 Two-component system # MISCELLANEOUS The 4Fe-4S clusters from PubMed 11884747 are renumbered in standard order. # Organism FDNH_ECOLI Escherichia coli (strain K12) # PATRIC 32118242 VBIEscCol129921_1541 # PDB 1KQF X-ray; 1.60 A; B=1-294 # PDB 1KQG X-ray; 2.80 A; B=1-294 # PIR F64900 JS0629 # PIRSF PIRSF036298 FDH_4Fe4S # PROSITE PS00198 4FE4S_FER_1 # PROSITE PS51379 4FE4S_FER_2; 4 # Pfam PF09163 Form-deh_trans # Pfam PF12800 Fer4_4 # Pfam PF13247 Fer4_11 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FDNH_ECOLI Formate dehydrogenase, nitrate-inducible, iron-sulfur subunit # RefSeq NP_415992 NC_000913.3 # RefSeq WP_001240582 NZ_LN832404.1 # SIMILARITY Contains 4 4Fe-4S ferredoxin-type domains. {ECO:0000255|PROSITE-ProRule PRU00711}. # SUBCELLULAR LOCATION FDNH_ECOLI Cell inner membrane {ECO 0000269|PubMed 11884747}; Single-pass membrane protein {ECO 0000269|PubMed 11884747}. # SUBUNIT Trimer of heterotrimers, consisting of subunits alpha, beta and gamma. {ECO:0000269|PubMed 11884747}. # TCDB 5.A.3.2 the prokaryotic molybdopterin-containing oxidoreductase (pmo) family # TIGRFAMs TIGR01582 FDH-beta # eggNOG COG0437 LUCA # eggNOG ENOG4105QA4 Bacteria BLAST swissprot:FDNH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FDNH_ECOLI BioCyc ECOL316407:JW1471-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1471-MONOMER BioCyc EcoCyc:FDNH-MONOMER http://biocyc.org/getid?id=EcoCyc:FDNH-MONOMER BioCyc MetaCyc:FDNH-MONOMER http://biocyc.org/getid?id=MetaCyc:FDNH-MONOMER COG COG0437 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0437 DIP DIP-35836N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35836N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1068186 http://dx.doi.org/10.1126/science.1068186 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M75029 http://www.ebi.ac.uk/ena/data/view/M75029 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1210 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1210 EcoGene EG11228 http://www.ecogene.org/geneInfo.php?eg_id=EG11228 EnsemblBacteria AAD13439 http://www.ensemblgenomes.org/id/AAD13439 EnsemblBacteria AAD13439 http://www.ensemblgenomes.org/id/AAD13439 EnsemblBacteria BAA15124 http://www.ensemblgenomes.org/id/BAA15124 EnsemblBacteria BAA15124 http://www.ensemblgenomes.org/id/BAA15124 EnsemblBacteria BAA15124 http://www.ensemblgenomes.org/id/BAA15124 EnsemblBacteria b1475 http://www.ensemblgenomes.org/id/b1475 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0009326 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009326 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0071575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071575 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0036397 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036397 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0009061 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009061 GO_process GO:0015944 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015944 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 948794 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948794 HOGENOM HOG000163382 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000163382&db=HOGENOM6 InParanoid P0AAJ3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAJ3 IntAct P0AAJ3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAJ3* InterPro IPR006470 http://www.ebi.ac.uk/interpro/entry/IPR006470 InterPro IPR014603 http://www.ebi.ac.uk/interpro/entry/IPR014603 InterPro IPR015246 http://www.ebi.ac.uk/interpro/entry/IPR015246 InterPro IPR017896 http://www.ebi.ac.uk/interpro/entry/IPR017896 InterPro IPR017900 http://www.ebi.ac.uk/interpro/entry/IPR017900 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Gene ecj:JW1471 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1471 KEGG_Gene eco:b1475 http://www.genome.jp/dbget-bin/www_bget?eco:b1475 KEGG_Orthology KO:K08349 http://www.genome.jp/dbget-bin/www_bget?KO:K08349 KEGG_Pathway ko00630 http://www.genome.jp/kegg-bin/show_pathway?ko00630 KEGG_Pathway ko00680 http://www.genome.jp/kegg-bin/show_pathway?ko00680 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 KEGG_Reaction rn:R00519 http://www.genome.jp/dbget-bin/www_bget?rn:R00519 MINT MINT-1286317 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1286317 OMA QQDNCIG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QQDNCIG PDB 1KQF http://www.ebi.ac.uk/pdbe-srv/view/entry/1KQF PDB 1KQG http://www.ebi.ac.uk/pdbe-srv/view/entry/1KQG PDBsum 1KQF http://www.ebi.ac.uk/pdbsum/1KQF PDBsum 1KQG http://www.ebi.ac.uk/pdbsum/1KQG PROSITE PS00198 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00198 PROSITE PS51379 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51379 PSORT swissprot:FDNH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FDNH_ECOLI PSORT-B swissprot:FDNH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FDNH_ECOLI PSORT2 swissprot:FDNH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FDNH_ECOLI Pfam PF09163 http://pfam.xfam.org/family/PF09163 Pfam PF12800 http://pfam.xfam.org/family/PF12800 Pfam PF13247 http://pfam.xfam.org/family/PF13247 Phobius swissprot:FDNH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FDNH_ECOLI PhylomeDB P0AAJ3 http://phylomedb.org/?seqid=P0AAJ3 ProteinModelPortal P0AAJ3 http://www.proteinmodelportal.org/query/uniprot/P0AAJ3 PubMed 11884747 http://www.ncbi.nlm.nih.gov/pubmed/11884747 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1834669 http://www.ncbi.nlm.nih.gov/pubmed/1834669 PubMed 2168848 http://www.ncbi.nlm.nih.gov/pubmed/2168848 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415992 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415992 RefSeq WP_001240582 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001240582 SMR P0AAJ3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAJ3 STRING 511145.b1475 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1475&targetmode=cogs STRING COG0437 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0437&targetmode=cogs TCDB 5.A.3.2 http://www.tcdb.org/search/result.php?tc=5.A.3.2 TIGRFAMs TIGR01582 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01582 UniProtKB FDNH_ECOLI http://www.uniprot.org/uniprot/FDNH_ECOLI UniProtKB-AC P0AAJ3 http://www.uniprot.org/uniprot/P0AAJ3 charge swissprot:FDNH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FDNH_ECOLI eggNOG COG0437 http://eggnogapi.embl.de/nog_data/html/tree/COG0437 eggNOG ENOG4105QA4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105QA4 epestfind swissprot:FDNH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FDNH_ECOLI garnier swissprot:FDNH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FDNH_ECOLI helixturnhelix swissprot:FDNH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FDNH_ECOLI hmoment swissprot:FDNH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FDNH_ECOLI iep swissprot:FDNH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FDNH_ECOLI inforesidue swissprot:FDNH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FDNH_ECOLI octanol swissprot:FDNH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FDNH_ECOLI pepcoil swissprot:FDNH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FDNH_ECOLI pepdigest swissprot:FDNH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FDNH_ECOLI pepinfo swissprot:FDNH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FDNH_ECOLI pepnet swissprot:FDNH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FDNH_ECOLI pepstats swissprot:FDNH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FDNH_ECOLI pepwheel swissprot:FDNH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FDNH_ECOLI pepwindow swissprot:FDNH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FDNH_ECOLI sigcleave swissprot:FDNH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FDNH_ECOLI ## Database ID URL or Descriptions # BioGrid 4260974 162 # EcoGene EG12548 yjhF # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0015128 gluconate transmembrane transporter activity; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # InterPro IPR003474 Glcn_transporter # KEGG_Brite ko02000 Transporters # Organism YJHF_ECOLI Escherichia coli (strain K12) # PATRIC 32124178 VBIEscCol129921_4432 # PIR B65243 B65243 # PIRSF PIRSF002746 Gluconate_transporter # Pfam PF02447 GntP_permease # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJHF_ECOLI Uncharacterized permease YjhF # RefSeq NP_418716 NC_000913.3 # RefSeq WP_001128363 NZ_LN832404.1 # SIMILARITY Belongs to the GntP permease family. {ECO 0000305}. # SUBCELLULAR LOCATION YJHF_ECOLI Cell inner membrane {ECO 0000305}; Multi- pass membrane protein {ECO 0000305}. # TCDB 2.A.8.1.11:the gluconate h(+) symporter (gntp) family # TIGRFAMs TIGR00791 gntP # eggNOG COG2610 LUCA # eggNOG ENOG4105C6Z Bacteria BLAST swissprot:YJHF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJHF_ECOLI BioCyc ECOL316407:JW4258-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4258-MONOMER BioCyc EcoCyc:YJHF-MONOMER http://biocyc.org/getid?id=EcoCyc:YJHF-MONOMER COG COG2610 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2610 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2436 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2436 EcoGene EG12548 http://www.ecogene.org/geneInfo.php?eg_id=EG12548 EnsemblBacteria AAC77252 http://www.ensemblgenomes.org/id/AAC77252 EnsemblBacteria AAC77252 http://www.ensemblgenomes.org/id/AAC77252 EnsemblBacteria BAE78287 http://www.ensemblgenomes.org/id/BAE78287 EnsemblBacteria BAE78287 http://www.ensemblgenomes.org/id/BAE78287 EnsemblBacteria BAE78287 http://www.ensemblgenomes.org/id/BAE78287 EnsemblBacteria b4296 http://www.ensemblgenomes.org/id/b4296 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015128 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015128 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GeneID 949102 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949102 HOGENOM HOG000237115 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000237115&db=HOGENOM6 InParanoid P39357 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39357 InterPro IPR003474 http://www.ebi.ac.uk/interpro/entry/IPR003474 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW4258 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4258 KEGG_Gene eco:b4296 http://www.genome.jp/dbget-bin/www_bget?eco:b4296 KEGG_Orthology KO:K03299 http://www.genome.jp/dbget-bin/www_bget?KO:K03299 OMA VYPKVYR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VYPKVYR PSORT swissprot:YJHF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJHF_ECOLI PSORT-B swissprot:YJHF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJHF_ECOLI PSORT2 swissprot:YJHF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJHF_ECOLI Pfam PF02447 http://pfam.xfam.org/family/PF02447 Phobius swissprot:YJHF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJHF_ECOLI PhylomeDB P39357 http://phylomedb.org/?seqid=P39357 ProteinModelPortal P39357 http://www.proteinmodelportal.org/query/uniprot/P39357 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418716 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418716 RefSeq WP_001128363 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001128363 STRING 511145.b4296 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4296&targetmode=cogs STRING COG2610 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2610&targetmode=cogs TCDB 2.A.8.1.11 http://www.tcdb.org/search/result.php?tc=2.A.8.1.11 TIGRFAMs TIGR00791 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00791 UniProtKB YJHF_ECOLI http://www.uniprot.org/uniprot/YJHF_ECOLI UniProtKB-AC P39357 http://www.uniprot.org/uniprot/P39357 charge swissprot:YJHF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJHF_ECOLI eggNOG COG2610 http://eggnogapi.embl.de/nog_data/html/tree/COG2610 eggNOG ENOG4105C6Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C6Z epestfind swissprot:YJHF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJHF_ECOLI garnier swissprot:YJHF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJHF_ECOLI helixturnhelix swissprot:YJHF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJHF_ECOLI hmoment swissprot:YJHF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJHF_ECOLI iep swissprot:YJHF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJHF_ECOLI inforesidue swissprot:YJHF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJHF_ECOLI octanol swissprot:YJHF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJHF_ECOLI pepcoil swissprot:YJHF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJHF_ECOLI pepdigest swissprot:YJHF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJHF_ECOLI pepinfo swissprot:YJHF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJHF_ECOLI pepnet swissprot:YJHF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJHF_ECOLI pepstats swissprot:YJHF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJHF_ECOLI pepwheel swissprot:YJHF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJHF_ECOLI pepwindow swissprot:YJHF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJHF_ECOLI sigcleave swissprot:YJHF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJHF_ECOLI ## Database ID URL or Descriptions # CDD cd00730 rubredoxin # COFACTOR Name=FMN; Xref=ChEBI:CHEBI 58210; Note=Binds 1 FMN per monomer.; # COFACTOR Name=Fe cation; Xref=ChEBI:CHEBI 24875; Note=Binds 3 Fe cations per monomer.; # EcoGene EG12963 norV # FUNCTION NORV_ECOLI Anaerobic nitric oxide reductase; uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center; electrons enter from the reductase at rubredoxin and are transferred sequentially to the FMN center and the di-iron center. Also able to function as an aerobic oxygen reductase. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0005506 iron ion binding; IDA:EcoCyc. # GO_function GO:0009055 electron carrier activity; IDA:EcoCyc. # GO_function GO:0010181 FMN binding; IDA:EcoCyc. # GO_function GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors; IDA:EcoCyc. # GO_function GO:0016966 nitric oxide reductase activity; IEA:InterPro. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0046210 nitric oxide catabolic process; IMP:EcoCyc. # GO_process GO:0051289 protein homotetramerization; IDA:EcoCyc. # GO_process GO:0071731 response to nitric oxide; IEP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 2.20.28.10 -; 1. # Gene3D 3.40.50.360 -; 1. # Gene3D 3.60.15.10 -; 1. # HAMAP MF_01312 NorV # INDUCTION NORV_ECOLI Submicromolar concentrations of NO induce NorV- dependent NO consumption; as NO reductase is sensitive to oxygen, no activity is detected in its presence. Repressed by oxygen in the presence of NO. Different effects on anaerobic induction in the absence of NO, and in the presence of N(O)3- or N(O)2- have been reported. Transcription is negatively regulated by FNR and does not require NarL or NarP. # IntAct Q46877 10 # InterPro IPR001279 Metallo-B-lactamas # InterPro IPR004039 Rubredoxin-type_fold # InterPro IPR008254 Flavodoxin/NO_synth # InterPro IPR016440 Rubredoxin-O_OxRdtase # InterPro IPR023957 Anaer_NO_rdtase_flvorubredoxin # InterPro IPR024934 Rubredoxin-like_dom # InterPro IPR024935 Rubredoxin_dom # InterPro IPR029039 Flavoprotein-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko05132 Salmonella infection # Organism NORV_ECOLI Escherichia coli (strain K12) # PATHWAY NORV_ECOLI Nitrogen metabolism; nitric oxide reduction. # PATRIC 32120818 VBIEscCol129921_2801 # PDB 2MS3 NMR; -; A=423-479 # PDB 4D02 X-ray; 1.76 A; A=1-479 # PDB 5LLD X-ray; 2.65 A; A=1-479 # PDB 5LMC X-ray; 1.90 A; A=1-479 # PIR B65051 B65051 # PIRSF PIRSF005243 ROO # PRINTS PR00163 RUBREDOXIN # PROSITE PS50902 FLAVODOXIN_LIKE # PROSITE PS50903 RUBREDOXIN_LIKE # Pfam PF00258 Flavodoxin_1 # Pfam PF00301 Rubredoxin # Pfam PF00753 Lactamase_B # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NORV_ECOLI Anaerobic nitric oxide reductase flavorubredoxin # RefSeq NP_417190 NC_000913.3 # RefSeq WP_000029634 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA05933.1; Type=Frameshift; Positions=134, 411; Evidence={ECO 0000305}; # SIMILARITY Contains 1 flavodoxin-like domain. {ECO 0000305}. # SIMILARITY Contains 1 rubredoxin-like domain. {ECO 0000305}. # SIMILARITY In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family. {ECO 0000305}. # SMART SM00849 Lactamase_B # SUBCELLULAR LOCATION NORV_ECOLI Cytoplasm. # SUBUNIT NORV_ECOLI Homotetramer. # SUPFAM SSF52218 SSF52218 # SUPFAM SSF56281 SSF56281 # eggNOG COG0426 LUCA # eggNOG COG1773 LUCA # eggNOG ENOG4108ESE Bacteria BLAST swissprot:NORV_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NORV_ECOLI BioCyc ECOL316407:JW2680-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2680-MONOMER BioCyc EcoCyc:G7413-MONOMER http://biocyc.org/getid?id=EcoCyc:G7413-MONOMER BioCyc MetaCyc:G7413-MONOMER http://biocyc.org/getid?id=MetaCyc:G7413-MONOMER COG COG0426 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0426 COG COG1773 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1773 DIP DIP-28070N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-28070N DOI 10.1016/S0378-1097(02)01186-2 http://dx.doi.org/10.1016/S0378-1097(02)01186-2 DOI 10.1021/bi001844y http://dx.doi.org/10.1021/bi001844y DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1432-1327.1998.2540325.x http://dx.doi.org/10.1046/j.1432-1327.1998.2540325.x DOI 10.1074/jbc.M110471200 http://dx.doi.org/10.1074/jbc.M110471200 DOI 10.1074/jbc.M203886200 http://dx.doi.org/10.1074/jbc.M203886200 DOI 10.1074/jbc.M212462200 http://dx.doi.org/10.1074/jbc.M212462200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D28595 http://www.ebi.ac.uk/ena/data/view/D28595 EMBL D28595 http://www.ebi.ac.uk/ena/data/view/D28595 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EchoBASE EB2793 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2793 EcoGene EG12963 http://www.ecogene.org/geneInfo.php?eg_id=EG12963 EnsemblBacteria AAC75752 http://www.ensemblgenomes.org/id/AAC75752 EnsemblBacteria AAC75752 http://www.ensemblgenomes.org/id/AAC75752 EnsemblBacteria BAE76787 http://www.ensemblgenomes.org/id/BAE76787 EnsemblBacteria BAE76787 http://www.ensemblgenomes.org/id/BAE76787 EnsemblBacteria BAE76787 http://www.ensemblgenomes.org/id/BAE76787 EnsemblBacteria b2710 http://www.ensemblgenomes.org/id/b2710 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0010181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010181 GO_function GO:0016661 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016661 GO_function GO:0016966 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016966 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0046210 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046210 GO_process GO:0051289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051289 GO_process GO:0071731 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071731 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 2.20.28.10 http://www.cathdb.info/version/latest/superfamily/2.20.28.10 Gene3D 3.40.50.360 http://www.cathdb.info/version/latest/superfamily/3.40.50.360 Gene3D 3.60.15.10 http://www.cathdb.info/version/latest/superfamily/3.60.15.10 GeneID 948979 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948979 HAMAP MF_01312 http://hamap.expasy.org/unirule/MF_01312 HOGENOM HOG000224529 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000224529&db=HOGENOM6 InParanoid Q46877 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46877 IntAct Q46877 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46877* InterPro IPR001279 http://www.ebi.ac.uk/interpro/entry/IPR001279 InterPro IPR004039 http://www.ebi.ac.uk/interpro/entry/IPR004039 InterPro IPR008254 http://www.ebi.ac.uk/interpro/entry/IPR008254 InterPro IPR016440 http://www.ebi.ac.uk/interpro/entry/IPR016440 InterPro IPR023957 http://www.ebi.ac.uk/interpro/entry/IPR023957 InterPro IPR024934 http://www.ebi.ac.uk/interpro/entry/IPR024934 InterPro IPR024935 http://www.ebi.ac.uk/interpro/entry/IPR024935 InterPro IPR029039 http://www.ebi.ac.uk/interpro/entry/IPR029039 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW2680 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2680 KEGG_Gene eco:b2710 http://www.genome.jp/dbget-bin/www_bget?eco:b2710 KEGG_Orthology KO:K12264 http://www.genome.jp/dbget-bin/www_bget?KO:K12264 KEGG_Pathway ko05132 http://www.genome.jp/kegg-bin/show_pathway?ko05132 OMA GWNGGAV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GWNGGAV PDB 2MS3 http://www.ebi.ac.uk/pdbe-srv/view/entry/2MS3 PDB 4D02 http://www.ebi.ac.uk/pdbe-srv/view/entry/4D02 PDB 5LLD http://www.ebi.ac.uk/pdbe-srv/view/entry/5LLD PDB 5LMC http://www.ebi.ac.uk/pdbe-srv/view/entry/5LMC PDBsum 2MS3 http://www.ebi.ac.uk/pdbsum/2MS3 PDBsum 4D02 http://www.ebi.ac.uk/pdbsum/4D02 PDBsum 5LLD http://www.ebi.ac.uk/pdbsum/5LLD PDBsum 5LMC http://www.ebi.ac.uk/pdbsum/5LMC PRINTS PR00163 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00163 PROSITE PS50902 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50902 PROSITE PS50903 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50903 PSORT swissprot:NORV_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NORV_ECOLI PSORT-B swissprot:NORV_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NORV_ECOLI PSORT2 swissprot:NORV_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NORV_ECOLI Pfam PF00258 http://pfam.xfam.org/family/PF00258 Pfam PF00301 http://pfam.xfam.org/family/PF00301 Pfam PF00753 http://pfam.xfam.org/family/PF00753 Phobius swissprot:NORV_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NORV_ECOLI PhylomeDB Q46877 http://phylomedb.org/?seqid=Q46877 ProteinModelPortal Q46877 http://www.proteinmodelportal.org/query/uniprot/Q46877 PubMed 11123953 http://www.ncbi.nlm.nih.gov/pubmed/11123953 PubMed 11751865 http://www.ncbi.nlm.nih.gov/pubmed/11751865 PubMed 12101220 http://www.ncbi.nlm.nih.gov/pubmed/12101220 PubMed 12529359 http://www.ncbi.nlm.nih.gov/pubmed/12529359 PubMed 12586421 http://www.ncbi.nlm.nih.gov/pubmed/12586421 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9660187 http://www.ncbi.nlm.nih.gov/pubmed/9660187 RefSeq NP_417190 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417190 RefSeq WP_000029634 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000029634 SMART SM00849 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00849 SMR Q46877 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46877 STRING 511145.b2710 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2710&targetmode=cogs STRING COG0426 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0426&targetmode=cogs STRING COG1773 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1773&targetmode=cogs SUPFAM SSF52218 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52218 SUPFAM SSF56281 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56281 UniProtKB NORV_ECOLI http://www.uniprot.org/uniprot/NORV_ECOLI UniProtKB-AC Q46877 http://www.uniprot.org/uniprot/Q46877 charge swissprot:NORV_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NORV_ECOLI eggNOG COG0426 http://eggnogapi.embl.de/nog_data/html/tree/COG0426 eggNOG COG1773 http://eggnogapi.embl.de/nog_data/html/tree/COG1773 eggNOG ENOG4108ESE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ESE epestfind swissprot:NORV_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NORV_ECOLI garnier swissprot:NORV_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NORV_ECOLI helixturnhelix swissprot:NORV_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NORV_ECOLI hmoment swissprot:NORV_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NORV_ECOLI iep swissprot:NORV_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NORV_ECOLI inforesidue swissprot:NORV_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NORV_ECOLI octanol swissprot:NORV_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NORV_ECOLI pepcoil swissprot:NORV_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NORV_ECOLI pepdigest swissprot:NORV_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NORV_ECOLI pepinfo swissprot:NORV_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NORV_ECOLI pepnet swissprot:NORV_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NORV_ECOLI pepstats swissprot:NORV_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NORV_ECOLI pepwheel swissprot:NORV_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NORV_ECOLI pepwindow swissprot:NORV_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NORV_ECOLI sigcleave swissprot:NORV_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NORV_ECOLI ## Database ID URL or Descriptions # BioGrid 4261539 146 # CDD cd06571 Bac_DnaA_C # EcoGene EG10235 dnaA # FUNCTION DNAA_ECOLI Also required for replication of plasmid DNA; binds 4 dnaA boxes in the minimal plasmid RK2 replication origin (oriV). # FUNCTION DNAA_ECOLI Plays a key role in the initiation and regulation of chromosomal replication. Binds in an ATP-dependent fashion to the origin of replication (oriC) to initiate formation of the DNA replication initiation complex exactly once per cell cycle. Binds the DnaA box (consensus sequence 5'-TTATC[CA]A[CA]A-3'); subsequent binding of DNA polymerase III subunits leads to replisome formation. The DnaA-ATP form converts to DnaA-ADP; once converted to ADP the protein cannot initiate replication, ensuring only 1 round of replication per cell cycle. DnaA can inhibit its own gene expression as well as that of other genes such as dam, rpoH, ftsA and mioC. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0003688 DNA replication origin binding; IMP:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0043565 sequence-specific DNA binding; IDA:EcoliWiki. # GO_process GO:0006260 DNA replication; IMP:EcoliWiki. # GO_process GO:0006270 DNA replication initiation; IBA:GO_Central. # GO_process GO:0006275 regulation of DNA replication; IMP:EcoliWiki. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0008156 negative regulation of DNA replication; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.1750.10 -; 1. # Gene3D 3.40.50.300 -; 1. # HAMAP MF_00377 DnaA_bact # INTERACTION DNAA_ECOLI P66817 diaA; NbExp=5; IntAct=EBI-548951, EBI-1125806; P0ACB0 dnaB; NbExp=4; IntAct=EBI-548951, EBI-548978; P0ABT2 dps; NbExp=2; IntAct=EBI-548951, EBI-549640; P69931 hda; NbExp=2; IntAct=EBI-548951, EBI-545453; P0ACF0 hupA; NbExp=5; IntAct=EBI-548951, EBI-547648; P60422 rplB; NbExp=4; IntAct=EBI-548951, EBI-543515; # IntAct P03004 44 # InterPro IPR001957 Chromosome_initiator_DnaA # InterPro IPR003593 AAA+_ATPase # InterPro IPR010921 Trp_repressor/repl_initiator # InterPro IPR013159 DnaA_C # InterPro IPR013317 DnaA # InterPro IPR018312 Chromosome_initiator_DnaA_CS # InterPro IPR020591 Chromosome_initiator_DnaA-like # InterPro IPR024633 DnaA_N_dom # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko03032 DNA replication proteins # KEGG_Brite ko03036 Chromosome # KEGG_Pathway ko02020 Two-component system # KEGG_Pathway ko04112 Cell cycle - Caulobacter # MISCELLANEOUS DNAA_ECOLI At least 4 systems specifically target DnaA to prevent more than 1 round of replication initiation per cell cycle. 1 SeqA binds to and sequesters hemimethylated oriC, preventing DnaA binding. 2 ATP-DnaA binds to the chromosomal datA locus, sequestering ATP-DnaA. 3 ATP-DnaA binds to its own promoter, repressing transcription. 4 RIDA (regulatory inactivation of DnaA) via Hda and the DNA-loaded beta clamp hydrolyzes ATP-DnaA to ADP-DnaA. # Organism DNAA_ECOLI Escherichia coli (strain K12) # PATRIC 32122901 VBIEscCol129921_3826 # PDB 1J1V X-ray; 2.10 A; A=374-467 # PDB 2E0G NMR; -; A=2-108 # PIR G65172 IQECDA # PRINTS PR00051 DNAA # PROSITE PS01008 DNAA # Pfam PF00308 Bac_DnaA # Pfam PF08299 Bac_DnaA_C # Pfam PF11638 DnaA_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DNAA_ECOLI Chromosomal replication initiator protein DnaA # RefSeq NP_418157 NC_000913.3 # RefSeq WP_000059111 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA62053.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the DnaA family. {ECO 0000305}. # SMART SM00382 AAA # SMART SM00760 Bac_DnaA_C # SUBCELLULAR LOCATION DNAA_ECOLI Cytoplasm. # SUBUNIT DNAA_ECOLI Some 20 DnaA protein molecules bind their sites in oriC. Forms the RIDA (regulatory inactivation of DnaA) complex with ATP- DnaA, ADP-Hda and the DNA-loaded sliding beta clamp (dnaN). Interacts with DiaA; this stimulates the association of DnaA with the origin of replication. {ECO 0000269|PubMed 17699754, ECO 0000269|PubMed 18977760}. # SUPFAM SSF48295 SSF48295 # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR00362 DnaA # eggNOG COG0593 LUCA # eggNOG ENOG4105CI4 Bacteria BLAST swissprot:DNAA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DNAA_ECOLI BioCyc ECOL316407:JW3679-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3679-MONOMER BioCyc EcoCyc:PD03831 http://biocyc.org/getid?id=EcoCyc:PD03831 COG COG0593 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0593 DIP DIP-9455N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9455N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1016/0168-9525(89)90118-2 http://dx.doi.org/10.1016/0168-9525(89)90118-2 DOI 10.1016/0378-1119(84)90253-1 http://dx.doi.org/10.1016/0378-1119(84)90253-1 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.272.32.20173 http://dx.doi.org/10.1074/jbc.272.32.20173 DOI 10.1074/jbc.M803158200 http://dx.doi.org/10.1074/jbc.M803158200 DOI 10.1093/nar/10.22.7373 http://dx.doi.org/10.1093/nar/10.22.7373 DOI 10.1093/nar/gkg309 http://dx.doi.org/10.1093/nar/gkg309 DOI 10.1101/gad.1561207 http://dx.doi.org/10.1101/gad.1561207 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.187.16.5605-5613.2005 http://dx.doi.org/10.1128/JB.187.16.5605-5613.2005 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01602 http://www.ebi.ac.uk/ena/data/view/J01602 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X01861 http://www.ebi.ac.uk/ena/data/view/X01861 EchoBASE EB0231 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0231 EcoGene EG10235 http://www.ecogene.org/geneInfo.php?eg_id=EG10235 EnsemblBacteria AAC76725 http://www.ensemblgenomes.org/id/AAC76725 EnsemblBacteria AAC76725 http://www.ensemblgenomes.org/id/AAC76725 EnsemblBacteria BAE77592 http://www.ensemblgenomes.org/id/BAE77592 EnsemblBacteria BAE77592 http://www.ensemblgenomes.org/id/BAE77592 EnsemblBacteria BAE77592 http://www.ensemblgenomes.org/id/BAE77592 EnsemblBacteria b3702 http://www.ensemblgenomes.org/id/b3702 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003688 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003688 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260 GO_process GO:0006270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006270 GO_process GO:0006275 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006275 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0008156 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008156 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.1750.10 http://www.cathdb.info/version/latest/superfamily/1.10.1750.10 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948217 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948217 HAMAP MF_00377 http://hamap.expasy.org/unirule/MF_00377 HOGENOM HOG000235659 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000235659&db=HOGENOM6 InParanoid P03004 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P03004 IntAct P03004 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P03004* InterPro IPR001957 http://www.ebi.ac.uk/interpro/entry/IPR001957 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR010921 http://www.ebi.ac.uk/interpro/entry/IPR010921 InterPro IPR013159 http://www.ebi.ac.uk/interpro/entry/IPR013159 InterPro IPR013317 http://www.ebi.ac.uk/interpro/entry/IPR013317 InterPro IPR018312 http://www.ebi.ac.uk/interpro/entry/IPR018312 InterPro IPR020591 http://www.ebi.ac.uk/interpro/entry/IPR020591 InterPro IPR024633 http://www.ebi.ac.uk/interpro/entry/IPR024633 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko03032 http://www.genome.jp/dbget-bin/www_bget?ko03032 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene ecj:JW3679 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3679 KEGG_Gene eco:b3702 http://www.genome.jp/dbget-bin/www_bget?eco:b3702 KEGG_Orthology KO:K02313 http://www.genome.jp/dbget-bin/www_bget?KO:K02313 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 KEGG_Pathway ko04112 http://www.genome.jp/kegg-bin/show_pathway?ko04112 MINT MINT-207293 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-207293 OMA QSKTRKR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QSKTRKR PDB 1J1V http://www.ebi.ac.uk/pdbe-srv/view/entry/1J1V PDB 2E0G http://www.ebi.ac.uk/pdbe-srv/view/entry/2E0G PDBsum 1J1V http://www.ebi.ac.uk/pdbsum/1J1V PDBsum 2E0G http://www.ebi.ac.uk/pdbsum/2E0G PRINTS PR00051 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00051 PROSITE PS01008 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01008 PSORT swissprot:DNAA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DNAA_ECOLI PSORT-B swissprot:DNAA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DNAA_ECOLI PSORT2 swissprot:DNAA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DNAA_ECOLI Pfam PF00308 http://pfam.xfam.org/family/PF00308 Pfam PF08299 http://pfam.xfam.org/family/PF08299 Pfam PF11638 http://pfam.xfam.org/family/PF11638 Phobius swissprot:DNAA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DNAA_ECOLI PhylomeDB P03004 http://phylomedb.org/?seqid=P03004 ProteinModelPortal P03004 http://www.proteinmodelportal.org/query/uniprot/P03004 PubMed 12682358 http://www.ncbi.nlm.nih.gov/pubmed/12682358 PubMed 16077105 http://www.ncbi.nlm.nih.gov/pubmed/16077105 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17699754 http://www.ncbi.nlm.nih.gov/pubmed/17699754 PubMed 18977760 http://www.ncbi.nlm.nih.gov/pubmed/18977760 PubMed 2558436 http://www.ncbi.nlm.nih.gov/pubmed/2558436 PubMed 6234204 http://www.ncbi.nlm.nih.gov/pubmed/6234204 PubMed 6296774 http://www.ncbi.nlm.nih.gov/pubmed/6296774 PubMed 6329723 http://www.ncbi.nlm.nih.gov/pubmed/6329723 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9242693 http://www.ncbi.nlm.nih.gov/pubmed/9242693 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_418157 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418157 RefSeq WP_000059111 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000059111 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMART SM00760 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00760 SMR P03004 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P03004 STRING 511145.b3702 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3702&targetmode=cogs STRING COG0593 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0593&targetmode=cogs SUPFAM SSF48295 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48295 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR00362 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00362 UniProtKB DNAA_ECOLI http://www.uniprot.org/uniprot/DNAA_ECOLI UniProtKB-AC P03004 http://www.uniprot.org/uniprot/P03004 charge swissprot:DNAA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DNAA_ECOLI eggNOG COG0593 http://eggnogapi.embl.de/nog_data/html/tree/COG0593 eggNOG ENOG4105CI4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CI4 epestfind swissprot:DNAA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DNAA_ECOLI garnier swissprot:DNAA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DNAA_ECOLI helixturnhelix swissprot:DNAA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DNAA_ECOLI hmoment swissprot:DNAA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DNAA_ECOLI iep swissprot:DNAA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DNAA_ECOLI inforesidue swissprot:DNAA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DNAA_ECOLI octanol swissprot:DNAA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DNAA_ECOLI pepcoil swissprot:DNAA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DNAA_ECOLI pepdigest swissprot:DNAA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DNAA_ECOLI pepinfo swissprot:DNAA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DNAA_ECOLI pepnet swissprot:DNAA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DNAA_ECOLI pepstats swissprot:DNAA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DNAA_ECOLI pepwheel swissprot:DNAA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DNAA_ECOLI pepwindow swissprot:DNAA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DNAA_ECOLI sigcleave swissprot:DNAA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DNAA_ECOLI ## Database ID URL or Descriptions # BioGrid 4263460 10 # EcoGene EG10491 iclR # FUNCTION ICLR_ECOLI Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyruvate enhances promoter binding by stabilizing the tetrameric form. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IBA:GO_Central. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IBA:GO_Central. # GO_process GO:0006097 glyoxylate cycle; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IMP:EcoCyc. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.10.10 -; 1. # Gene3D 3.30.450.40 -; 1. # IntAct P16528 17 # InterPro IPR005471 Tscrpt_reg_IclR_N # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR014757 Tscrpt_reg_IclR_C # InterPro IPR029016 GAF_dom-like # KEGG_Brite ko03000 Transcription factors # MISCELLANEOUS ICLR_ECOLI Glyoxylate and pyruvate occupy the same site. # Organism ICLR_ECOLI Escherichia coli (strain K12) # PATRIC 32123565 VBIEscCol129921_4131 # PDB 1TD5 X-ray; 2.30 A; A/B/C/D=98-274 # PDB 2O99 X-ray; 1.70 A; A/B/C/D=98-274 # PDB 2O9A X-ray; 1.80 A; A/B/C/D=98-274 # PROSITE PS51077 HTH_ICLR # PROSITE PS51078 ICLR_ED # Pfam PF01614 IclR # Pfam PF09339 HTH_IclR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ICLR_ECOLI Acetate operon repressor # RefSeq NP_418442 NC_000913.3 # RefSeq WP_000226403 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA50561.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAC43112.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Contains 1 HTH iclR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00393}. # SIMILARITY Contains 1 iclR-ED (iclR effector binding) domain. {ECO:0000255|PROSITE-ProRule PRU00394}. # SMART SM00346 HTH_ICLR # SUBUNIT Homotetramer and homodimer. Homotetramer in its active, DNA-bound form. Homodimer in its inactive form. {ECO:0000269|PubMed 17426033}. # SUPFAM SSF46785 SSF46785 # SUPFAM SSF55781 SSF55781 # eggNOG COG1414 LUCA # eggNOG ENOG41069M3 Bacteria BLAST swissprot:ICLR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ICLR_ECOLI BioCyc ECOL316407:JW3978-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3978-MONOMER BioCyc EcoCyc:PD04099 http://biocyc.org/getid?id=EcoCyc:PD04099 COG COG1414 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1414 DIP DIP-10008N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10008N DOI 10.1016/0378-1119(91)90006-W http://dx.doi.org/10.1016/0378-1119(91)90006-W DOI 10.1016/0378-1119(91)90024-6 http://dx.doi.org/10.1016/0378-1119(91)90024-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M610838200 http://dx.doi.org/10.1074/jbc.M610838200 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M31761 http://www.ebi.ac.uk/ena/data/view/M31761 EMBL M63497 http://www.ebi.ac.uk/ena/data/view/M63497 EMBL M63914 http://www.ebi.ac.uk/ena/data/view/M63914 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0486 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0486 EcoGene EG10491 http://www.ecogene.org/geneInfo.php?eg_id=EG10491 EnsemblBacteria AAC76988 http://www.ensemblgenomes.org/id/AAC76988 EnsemblBacteria AAC76988 http://www.ensemblgenomes.org/id/AAC76988 EnsemblBacteria BAE78020 http://www.ensemblgenomes.org/id/BAE78020 EnsemblBacteria BAE78020 http://www.ensemblgenomes.org/id/BAE78020 EnsemblBacteria BAE78020 http://www.ensemblgenomes.org/id/BAE78020 EnsemblBacteria b4018 http://www.ensemblgenomes.org/id/b4018 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006097 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006097 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 3.30.450.40 http://www.cathdb.info/version/latest/superfamily/3.30.450.40 GeneID 948524 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948524 HOGENOM HOG000107041 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000107041&db=HOGENOM6 InParanoid P16528 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P16528 IntAct P16528 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P16528* InterPro IPR005471 http://www.ebi.ac.uk/interpro/entry/IPR005471 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR014757 http://www.ebi.ac.uk/interpro/entry/IPR014757 InterPro IPR029016 http://www.ebi.ac.uk/interpro/entry/IPR029016 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW3978 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3978 KEGG_Gene eco:b4018 http://www.genome.jp/dbget-bin/www_bget?eco:b4018 KEGG_Orthology KO:K13641 http://www.genome.jp/dbget-bin/www_bget?KO:K13641 MINT MINT-1226737 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1226737 OMA IAACIFD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IAACIFD PDB 1TD5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1TD5 PDB 2O99 http://www.ebi.ac.uk/pdbe-srv/view/entry/2O99 PDB 2O9A http://www.ebi.ac.uk/pdbe-srv/view/entry/2O9A PDBsum 1TD5 http://www.ebi.ac.uk/pdbsum/1TD5 PDBsum 2O99 http://www.ebi.ac.uk/pdbsum/2O99 PDBsum 2O9A http://www.ebi.ac.uk/pdbsum/2O9A PROSITE PS51077 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51077 PROSITE PS51078 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51078 PSORT swissprot:ICLR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ICLR_ECOLI PSORT-B swissprot:ICLR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ICLR_ECOLI PSORT2 swissprot:ICLR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ICLR_ECOLI Pfam PF01614 http://pfam.xfam.org/family/PF01614 Pfam PF09339 http://pfam.xfam.org/family/PF09339 Phobius swissprot:ICLR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ICLR_ECOLI PhylomeDB P16528 http://phylomedb.org/?seqid=P16528 ProteinModelPortal P16528 http://www.proteinmodelportal.org/query/uniprot/P16528 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17426033 http://www.ncbi.nlm.nih.gov/pubmed/17426033 PubMed 1995429 http://www.ncbi.nlm.nih.gov/pubmed/1995429 PubMed 1995431 http://www.ncbi.nlm.nih.gov/pubmed/1995431 PubMed 2185227 http://www.ncbi.nlm.nih.gov/pubmed/2185227 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418442 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418442 RefSeq WP_000226403 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000226403 SMART SM00346 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00346 SMR P16528 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P16528 STRING 511145.b4018 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4018&targetmode=cogs STRING COG1414 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1414&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SUPFAM SSF55781 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55781 UniProtKB ICLR_ECOLI http://www.uniprot.org/uniprot/ICLR_ECOLI UniProtKB-AC P16528 http://www.uniprot.org/uniprot/P16528 charge swissprot:ICLR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ICLR_ECOLI eggNOG COG1414 http://eggnogapi.embl.de/nog_data/html/tree/COG1414 eggNOG ENOG41069M3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41069M3 epestfind swissprot:ICLR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ICLR_ECOLI garnier swissprot:ICLR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ICLR_ECOLI helixturnhelix swissprot:ICLR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ICLR_ECOLI hmoment swissprot:ICLR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ICLR_ECOLI iep swissprot:ICLR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ICLR_ECOLI inforesidue swissprot:ICLR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ICLR_ECOLI octanol swissprot:ICLR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ICLR_ECOLI pepcoil swissprot:ICLR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ICLR_ECOLI pepdigest swissprot:ICLR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ICLR_ECOLI pepinfo swissprot:ICLR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ICLR_ECOLI pepnet swissprot:ICLR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ICLR_ECOLI pepstats swissprot:ICLR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ICLR_ECOLI pepwheel swissprot:ICLR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ICLR_ECOLI pepwindow swissprot:ICLR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ICLR_ECOLI sigcleave swissprot:ICLR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ICLR_ECOLI ## Database ID URL or Descriptions # BioGrid 4263308 102 # CAZy GT2 Glycosyltransferase Family 2 # EcoGene EG11266 yibD # GO_component GO:0016020 membrane; IDA:EcoCyc. # GO_function GO:0015020 glucuronosyltransferase activity; IMP:EcoCyc. # GO_process GO:0016036 cellular response to phosphate starvation; IEP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_process GO:0006950 response to stress # Gene3D 3.90.550.10 -; 1. # IntAct P11290 4 # InterPro IPR001173 Glyco_trans_2-like # InterPro IPR029044 Nucleotide-diphossugar_trans # Organism YIBD_ECOLI Escherichia coli (strain K12) # PATRIC 32122717 VBIEscCol129921_3735 # PIR S47836 Q3ECTH # Pfam PF00535 Glycos_transf_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIBD_ECOLI Uncharacterized glycosyltransferase YibD # RefSeq NP_418072 NC_000913.3 # RefSeq WP_000982115 NZ_LN832404.1 # SIMILARITY Belongs to the glycosyltransferase 2 family. {ECO 0000305}. # SUPFAM SSF53448 SSF53448 # eggNOG COG0463 LUCA # eggNOG ENOG4105K64 Bacteria BLAST swissprot:YIBD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIBD_ECOLI BioCyc ECOL316407:JW3590-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3590-MONOMER BioCyc EcoCyc:EG11266-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11266-MONOMER BioCyc MetaCyc:EG11266-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11266-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.4.-.- http://www.genome.jp/dbget-bin/www_bget?EC:2.4.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X06690 http://www.ebi.ac.uk/ena/data/view/X06690 ENZYME 2.4.-.- http://enzyme.expasy.org/EC/2.4.-.- EchoBASE EB1245 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1245 EcoGene EG11266 http://www.ecogene.org/geneInfo.php?eg_id=EG11266 EnsemblBacteria AAC76639 http://www.ensemblgenomes.org/id/AAC76639 EnsemblBacteria AAC76639 http://www.ensemblgenomes.org/id/AAC76639 EnsemblBacteria BAE77677 http://www.ensemblgenomes.org/id/BAE77677 EnsemblBacteria BAE77677 http://www.ensemblgenomes.org/id/BAE77677 EnsemblBacteria BAE77677 http://www.ensemblgenomes.org/id/BAE77677 EnsemblBacteria b3615 http://www.ensemblgenomes.org/id/b3615 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0015020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015020 GO_process GO:0016036 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016036 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.90.550.10 http://www.cathdb.info/version/latest/superfamily/3.90.550.10 GeneID 948140 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948140 HOGENOM HOG000126147 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126147&db=HOGENOM6 InParanoid P11290 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P11290 IntAct P11290 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P11290* IntEnz 2.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4 InterPro IPR001173 http://www.ebi.ac.uk/interpro/entry/IPR001173 InterPro IPR029044 http://www.ebi.ac.uk/interpro/entry/IPR029044 KEGG_Gene ecj:JW3590 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3590 KEGG_Gene eco:b3615 http://www.genome.jp/dbget-bin/www_bget?eco:b3615 OMA MRSARHY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MRSARHY PSORT swissprot:YIBD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIBD_ECOLI PSORT-B swissprot:YIBD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIBD_ECOLI PSORT2 swissprot:YIBD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIBD_ECOLI Pfam PF00535 http://pfam.xfam.org/family/PF00535 Phobius swissprot:YIBD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIBD_ECOLI PhylomeDB P11290 http://phylomedb.org/?seqid=P11290 ProteinModelPortal P11290 http://www.proteinmodelportal.org/query/uniprot/P11290 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2647748 http://www.ncbi.nlm.nih.gov/pubmed/2647748 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418072 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418072 RefSeq WP_000982115 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000982115 SMR P11290 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P11290 STRING 511145.b3615 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3615&targetmode=cogs SUPFAM SSF53448 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53448 UniProtKB YIBD_ECOLI http://www.uniprot.org/uniprot/YIBD_ECOLI UniProtKB-AC P11290 http://www.uniprot.org/uniprot/P11290 charge swissprot:YIBD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIBD_ECOLI eggNOG COG0463 http://eggnogapi.embl.de/nog_data/html/tree/COG0463 eggNOG ENOG4105K64 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K64 epestfind swissprot:YIBD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIBD_ECOLI garnier swissprot:YIBD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIBD_ECOLI helixturnhelix swissprot:YIBD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIBD_ECOLI hmoment swissprot:YIBD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIBD_ECOLI iep swissprot:YIBD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIBD_ECOLI inforesidue swissprot:YIBD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIBD_ECOLI octanol swissprot:YIBD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIBD_ECOLI pepcoil swissprot:YIBD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIBD_ECOLI pepdigest swissprot:YIBD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIBD_ECOLI pepinfo swissprot:YIBD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIBD_ECOLI pepnet swissprot:YIBD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIBD_ECOLI pepstats swissprot:YIBD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIBD_ECOLI pepwheel swissprot:YIBD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIBD_ECOLI pepwindow swissprot:YIBD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIBD_ECOLI sigcleave swissprot:YIBD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIBD_ECOLI ## Database ID URL or Descriptions # BioGrid 4262597 8 # EcoGene EG11721 yidZ # FUNCTION YIDZ_ECOLI Involved in anaerobic NO protection. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006351 transcription, DNA-templated; IMP:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IBA:GO_Central. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # HAMAP MF_01607 HTH_type_YidZ # IntAct P31463 2 # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR005119 LysR_subst-bd # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR023746 Tscrpt_reg_YidZ # Organism YIDZ_ECOLI Escherichia coli (strain K12) # PATRIC 32122917 VBIEscCol129921_3834 # PIR H65173 H65173 # PROSITE PS50931 HTH_LYSR # Pfam PF00126 HTH_1 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIDZ_ECOLI HTH-type transcriptional regulator YidZ # RefSeq NP_418167 NC_000913.3 # RefSeq WP_001311238 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lysR-type DNA-binding domain. {ECO 0000305}. # SUPFAM SSF46785 SSF46785 # eggNOG ENOG4105G2Y Bacteria # eggNOG ENOG410XRYC LUCA BLAST swissprot:YIDZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIDZ_ECOLI BioCyc ECOL316407:JW3689-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3689-MONOMER BioCyc EcoCyc:EG11721-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11721-MONOMER DIP DIP-12458N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12458N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M411070200 http://dx.doi.org/10.1074/jbc.M411070200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1672 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1672 EcoGene EG11721 http://www.ecogene.org/geneInfo.php?eg_id=EG11721 EnsemblBacteria AAC76734 http://www.ensemblgenomes.org/id/AAC76734 EnsemblBacteria AAC76734 http://www.ensemblgenomes.org/id/AAC76734 EnsemblBacteria BAE77579 http://www.ensemblgenomes.org/id/BAE77579 EnsemblBacteria BAE77579 http://www.ensemblgenomes.org/id/BAE77579 EnsemblBacteria BAE77579 http://www.ensemblgenomes.org/id/BAE77579 EnsemblBacteria b3711 http://www.ensemblgenomes.org/id/b3711 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 948227 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948227 HAMAP MF_01607 http://hamap.expasy.org/unirule/MF_01607 HOGENOM HOG000103694 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000103694&db=HOGENOM6 IntAct P31463 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31463* InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR023746 http://www.ebi.ac.uk/interpro/entry/IPR023746 KEGG_Gene ecj:JW3689 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3689 KEGG_Gene eco:b3711 http://www.genome.jp/dbget-bin/www_bget?eco:b3711 MINT MINT-1257535 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1257535 OMA LDKPHHE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LDKPHHE PROSITE PS50931 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50931 PSORT swissprot:YIDZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIDZ_ECOLI PSORT-B swissprot:YIDZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIDZ_ECOLI PSORT2 swissprot:YIDZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIDZ_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:YIDZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIDZ_ECOLI PhylomeDB P31463 http://phylomedb.org/?seqid=P31463 ProteinModelPortal P31463 http://www.proteinmodelportal.org/query/uniprot/P31463 PubMed 15546870 http://www.ncbi.nlm.nih.gov/pubmed/15546870 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418167 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418167 RefSeq WP_001311238 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001311238 SMR P31463 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31463 STRING 511145.b3711 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3711&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB YIDZ_ECOLI http://www.uniprot.org/uniprot/YIDZ_ECOLI UniProtKB-AC P31463 http://www.uniprot.org/uniprot/P31463 charge swissprot:YIDZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIDZ_ECOLI eggNOG ENOG4105G2Y http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105G2Y eggNOG ENOG410XRYC http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRYC epestfind swissprot:YIDZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIDZ_ECOLI garnier swissprot:YIDZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIDZ_ECOLI helixturnhelix swissprot:YIDZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIDZ_ECOLI hmoment swissprot:YIDZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIDZ_ECOLI iep swissprot:YIDZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIDZ_ECOLI inforesidue swissprot:YIDZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIDZ_ECOLI octanol swissprot:YIDZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIDZ_ECOLI pepcoil swissprot:YIDZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIDZ_ECOLI pepdigest swissprot:YIDZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIDZ_ECOLI pepinfo swissprot:YIDZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIDZ_ECOLI pepnet swissprot:YIDZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIDZ_ECOLI pepstats swissprot:YIDZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIDZ_ECOLI pepwheel swissprot:YIDZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIDZ_ECOLI pepwindow swissprot:YIDZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIDZ_ECOLI sigcleave swissprot:YIDZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIDZ_ECOLI ## Database ID URL or Descriptions # AltName INTS_ECOLI Putative prophage CPS-53 integrase # BioGrid 4259384 12 # EcoGene EG12413 intS # FUNCTION INTS_ECOLI Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome. # GO_function GO:0008979 prophage integrase activity; IBA:GO_Central. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0043565 sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0006310 DNA recombination; IEA:UniProtKB-KW. # GO_process GO:0032359 provirus excision; IMP:EcoCyc. # GO_process GO:0046718 viral entry into host cell; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0044403 symbiosis, encompassing mutualism through parasitism # Gene3D 1.10.150.130 -; 1. # Gene3D 1.10.443.10 -; 1. # IntAct P37326 12 # InterPro IPR002104 Integrase_catalytic # InterPro IPR004107 Integrase_SAM-like_N # InterPro IPR011010 DNA_brk_join_enz # InterPro IPR013762 Integrase-like_cat # InterPro IPR023109 Integrase_recombinase_N # InterPro IPR025166 DUF4102 # Organism INTS_ECOLI Escherichia coli (strain K12) # PATRIC 32120073 VBIEscCol129921_2445 # PDB 2KJ8 NMR; -; A=87-196 # PIR I84552 I84552 # Pfam PF00589 Phage_integrase # Pfam PF13356 DUF4102 # Pfam PF14659 Phage_int_SAM_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Prophage integrase IntS {ECO 0000305} # RefSeq NP_416850 NC_000913.3 # RefSeq WP_000958671 NZ_LN832404.1 # SIMILARITY Belongs to the 'phage' integrase family. {ECO 0000305}. # SUPFAM SSF56349 SSF56349 # eggNOG COG0582 LUCA # eggNOG ENOG4105DFP Bacteria BLAST swissprot:INTS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INTS_ECOLI BioCyc ECOL316407:JW2345-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2345-MONOMER BioCyc EcoCyc:G7218-MONOMER http://biocyc.org/getid?id=EcoCyc:G7218-MONOMER DIP DIP-10041N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10041N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U11296 http://www.ebi.ac.uk/ena/data/view/U11296 EchoBASE EB2312 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2312 EcoGene EG12413 http://www.ecogene.org/geneInfo.php?eg_id=EG12413 EnsemblBacteria AAC75408 http://www.ensemblgenomes.org/id/AAC75408 EnsemblBacteria AAC75408 http://www.ensemblgenomes.org/id/AAC75408 EnsemblBacteria BAA16208 http://www.ensemblgenomes.org/id/BAA16208 EnsemblBacteria BAA16208 http://www.ensemblgenomes.org/id/BAA16208 EnsemblBacteria BAA16208 http://www.ensemblgenomes.org/id/BAA16208 EnsemblBacteria b2349 http://www.ensemblgenomes.org/id/b2349 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008979 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0032359 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032359 GO_process GO:0046718 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046718 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0044403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403 Gene3D 1.10.150.130 http://www.cathdb.info/version/latest/superfamily/1.10.150.130 Gene3D 1.10.443.10 http://www.cathdb.info/version/latest/superfamily/1.10.443.10 GeneID 946821 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946821 HOGENOM HOG000263105 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000263105&db=HOGENOM6 InParanoid P37326 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37326 IntAct P37326 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37326* InterPro IPR002104 http://www.ebi.ac.uk/interpro/entry/IPR002104 InterPro IPR004107 http://www.ebi.ac.uk/interpro/entry/IPR004107 InterPro IPR011010 http://www.ebi.ac.uk/interpro/entry/IPR011010 InterPro IPR013762 http://www.ebi.ac.uk/interpro/entry/IPR013762 InterPro IPR023109 http://www.ebi.ac.uk/interpro/entry/IPR023109 InterPro IPR025166 http://www.ebi.ac.uk/interpro/entry/IPR025166 KEGG_Gene ecj:JW2345 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2345 KEGG_Gene eco:b2349 http://www.genome.jp/dbget-bin/www_bget?eco:b2349 OMA QIPAFNQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QIPAFNQ PDB 2KJ8 http://www.ebi.ac.uk/pdbe-srv/view/entry/2KJ8 PDBsum 2KJ8 http://www.ebi.ac.uk/pdbsum/2KJ8 PSORT swissprot:INTS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INTS_ECOLI PSORT-B swissprot:INTS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INTS_ECOLI PSORT2 swissprot:INTS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INTS_ECOLI Pfam PF00589 http://pfam.xfam.org/family/PF00589 Pfam PF13356 http://pfam.xfam.org/family/PF13356 Pfam PF14659 http://pfam.xfam.org/family/PF14659 Phobius swissprot:INTS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INTS_ECOLI PhylomeDB P37326 http://phylomedb.org/?seqid=P37326 ProteinModelPortal P37326 http://www.proteinmodelportal.org/query/uniprot/P37326 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416850 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416850 RefSeq WP_000958671 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000958671 SMR P37326 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37326 STRING 511145.b2349 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2349&targetmode=cogs SUPFAM SSF56349 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56349 UniProtKB INTS_ECOLI http://www.uniprot.org/uniprot/INTS_ECOLI UniProtKB-AC P37326 http://www.uniprot.org/uniprot/P37326 charge swissprot:INTS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INTS_ECOLI eggNOG COG0582 http://eggnogapi.embl.de/nog_data/html/tree/COG0582 eggNOG ENOG4105DFP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DFP epestfind swissprot:INTS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INTS_ECOLI garnier swissprot:INTS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INTS_ECOLI helixturnhelix swissprot:INTS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INTS_ECOLI hmoment swissprot:INTS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INTS_ECOLI iep swissprot:INTS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INTS_ECOLI inforesidue swissprot:INTS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INTS_ECOLI octanol swissprot:INTS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INTS_ECOLI pepcoil swissprot:INTS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INTS_ECOLI pepdigest swissprot:INTS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INTS_ECOLI pepinfo swissprot:INTS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INTS_ECOLI pepnet swissprot:INTS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INTS_ECOLI pepstats swissprot:INTS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INTS_ECOLI pepwheel swissprot:INTS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INTS_ECOLI pepwindow swissprot:INTS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INTS_ECOLI sigcleave swissprot:INTS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INTS_ECOLI ## Database ID URL or Descriptions # AltName GDP-D-mannose dehydratase {ECO:0000255|HAMAP-Rule MF_00955} # BioGrid 4259690 186 # CATALYTIC ACTIVITY GM4D_ECOLI GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D- rhamnose + H(2)O. {ECO 0000255|HAMAP-Rule MF_00955, ECO 0000269|PubMed 9257704}. # COFACTOR GM4D_ECOLI Name=NADP(+); Xref=ChEBI CHEBI 58349; Evidence={ECO 0000255|HAMAP-Rule MF_00955, ECO 0000269|PubMed 10673432, ECO 0000269|PubMed 9257704}; # EcoGene EG11787 gmd # FUNCTION GM4D_ECOLI Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose. {ECO 0000255|HAMAP-Rule MF_00955, ECO 0000269|PubMed 9257704}. # GO_function GO:0008446 GDP-mannose 4,6-dehydratase activity; IDA:EcoCyc. # GO_function GO:0070401 NADP+ binding; IEA:UniProtKB-HAMAP. # GO_process GO:0009242 colanic acid biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0019673 GDP-mannose metabolic process; IEA:InterPro. # GO_process GO:0042351 'de novo' GDP-L-fucose biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.50.720 -; 1. # HAMAP MF_00955 GDP_Man_dehydratase # IntAct P0AC88 2 # InterPro IPR006368 GDP_Man_deHydtase # InterPro IPR016040 NAD(P)-bd_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00051 Fructose and mannose metabolism # KEGG_Pathway ko00520 Amino sugar and nucleotide sugar metabolism # Organism GM4D_ECOLI Escherichia coli (strain K12) # PATHWAY Exopolysaccharide biosynthesis; colanic acid biosynthesis. {ECO:0000269|PubMed 9257704}. # PATHWAY Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 1/2. {ECO 0000269|PubMed:9257704}. # PATRIC 32119439 VBIEscCol129921_2130 # PDB 1DB3 X-ray; 2.30 A; A=2-373 # PIR D64971 D64971 # Pfam PF16363 GDP_Man_Dehyd # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GDP-mannose 4,6-dehydratase {ECO:0000255|HAMAP-Rule MF_00955} # RefSeq NP_416557 NC_000913.3 # RefSeq WP_000048190 NZ_LN832404.1 # SIMILARITY Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily. {ECO:0000255|HAMAP- Rule MF_00955}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 10673432}. # SUPFAM SSF51735 SSF51735 # TIGRFAMs TIGR01472 gmd # UniPathway UPA00128 UER00190 # eggNOG COG1089 LUCA # eggNOG ENOG4105C0K Bacteria BLAST swissprot:GM4D_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GM4D_ECOLI BioCyc ECOL316407:JW2038-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2038-MONOMER BioCyc EcoCyc:GDPMANDEHYDRA-MONOMER http://biocyc.org/getid?id=EcoCyc:GDPMANDEHYDRA-MONOMER BioCyc MetaCyc:GDPMANDEHYDRA-MONOMER http://biocyc.org/getid?id=MetaCyc:GDPMANDEHYDRA-MONOMER COG COG1089 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1089 DIP DIP-48216N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48216N DOI 10.1016/S0014-5793(97)00762-X http://dx.doi.org/10.1016/S0014-5793(97)00762-X DOI 10.1016/S0969-2126(00)00088-5 http://dx.doi.org/10.1016/S0969-2126(00)00088-5 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.1.47 {ECO:0000255|HAMAP-Rule:MF_00955} http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.47 {ECO:0000255|HAMAP-Rule:MF_00955} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U38473 http://www.ebi.ac.uk/ena/data/view/U38473 ENZYME 4.2.1.47 {ECO:0000255|HAMAP-Rule:MF_00955} http://enzyme.expasy.org/EC/4.2.1.47 {ECO:0000255|HAMAP-Rule:MF_00955} EchoBASE EB1735 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1735 EcoGene EG11787 http://www.ecogene.org/geneInfo.php?eg_id=EG11787 EnsemblBacteria AAC75114 http://www.ensemblgenomes.org/id/AAC75114 EnsemblBacteria AAC75114 http://www.ensemblgenomes.org/id/AAC75114 EnsemblBacteria BAA15909 http://www.ensemblgenomes.org/id/BAA15909 EnsemblBacteria BAA15909 http://www.ensemblgenomes.org/id/BAA15909 EnsemblBacteria BAA15909 http://www.ensemblgenomes.org/id/BAA15909 EnsemblBacteria b2053 http://www.ensemblgenomes.org/id/b2053 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008446 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008446 GO_function GO:0070401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070401 GO_process GO:0009242 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009242 GO_process GO:0019673 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019673 GO_process GO:0042351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042351 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 946562 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946562 HAMAP MF_00955 http://hamap.expasy.org/unirule/MF_00955 HOGENOM HOG000168003 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000168003&db=HOGENOM6 InParanoid P0AC88 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AC88 IntAct P0AC88 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AC88* IntEnz 4.2.1.47 {ECO:0000255|HAMAP-Rule:MF_00955} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.47 {ECO:0000255|HAMAP-Rule:MF_00955} InterPro IPR006368 http://www.ebi.ac.uk/interpro/entry/IPR006368 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2038 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2038 KEGG_Gene eco:b2053 http://www.genome.jp/dbget-bin/www_bget?eco:b2053 KEGG_Orthology KO:K01711 http://www.genome.jp/dbget-bin/www_bget?KO:K01711 KEGG_Pathway ko00051 http://www.genome.jp/kegg-bin/show_pathway?ko00051 KEGG_Pathway ko00520 http://www.genome.jp/kegg-bin/show_pathway?ko00520 KEGG_Reaction rn:R00888 http://www.genome.jp/dbget-bin/www_bget?rn:R00888 OMA DYQHRTG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DYQHRTG PDB 1DB3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1DB3 PDBsum 1DB3 http://www.ebi.ac.uk/pdbsum/1DB3 PSORT swissprot:GM4D_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GM4D_ECOLI PSORT-B swissprot:GM4D_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GM4D_ECOLI PSORT2 swissprot:GM4D_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GM4D_ECOLI Pfam PF16363 http://pfam.xfam.org/family/PF16363 Phobius swissprot:GM4D_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GM4D_ECOLI PhylomeDB P0AC88 http://phylomedb.org/?seqid=P0AC88 ProteinModelPortal P0AC88 http://www.proteinmodelportal.org/query/uniprot/P0AC88 PubMed 10673432 http://www.ncbi.nlm.nih.gov/pubmed/10673432 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7815923 http://www.ncbi.nlm.nih.gov/pubmed/7815923 PubMed 8759852 http://www.ncbi.nlm.nih.gov/pubmed/8759852 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9257704 http://www.ncbi.nlm.nih.gov/pubmed/9257704 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416557 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416557 RefSeq WP_000048190 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000048190 SMR P0AC88 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AC88 STRING 511145.b2053 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2053&targetmode=cogs STRING COG1089 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1089&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 TIGRFAMs TIGR01472 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01472 UniProtKB GM4D_ECOLI http://www.uniprot.org/uniprot/GM4D_ECOLI UniProtKB-AC P0AC88 http://www.uniprot.org/uniprot/P0AC88 charge swissprot:GM4D_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GM4D_ECOLI eggNOG COG1089 http://eggnogapi.embl.de/nog_data/html/tree/COG1089 eggNOG ENOG4105C0K http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C0K epestfind swissprot:GM4D_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GM4D_ECOLI garnier swissprot:GM4D_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GM4D_ECOLI helixturnhelix swissprot:GM4D_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GM4D_ECOLI hmoment swissprot:GM4D_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GM4D_ECOLI iep swissprot:GM4D_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GM4D_ECOLI inforesidue swissprot:GM4D_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GM4D_ECOLI octanol swissprot:GM4D_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GM4D_ECOLI pepcoil swissprot:GM4D_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GM4D_ECOLI pepdigest swissprot:GM4D_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GM4D_ECOLI pepinfo swissprot:GM4D_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GM4D_ECOLI pepnet swissprot:GM4D_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GM4D_ECOLI pepstats swissprot:GM4D_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GM4D_ECOLI pepwheel swissprot:GM4D_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GM4D_ECOLI pepwindow swissprot:GM4D_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GM4D_ECOLI sigcleave swissprot:GM4D_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GM4D_ECOLI ## Database ID URL or Descriptions # AltName NifS protein homolog {ECO:0000303|PubMed 8663056} # AltName ThiI transpersulfidase {ECO:0000303|PubMed 10600118} # AltName TusA transpersulfidase {ECO:0000303|PubMed 16387657} # BIOPHYSICOCHEMICAL PROPERTIES ISCS_ECOLI Kinetic parameters KM=2.7 uM for L-cysteine {ECO 0000269|PubMed 11577100}; Note=kcat is 8.5 min(-1). {ECO 0000269|PubMed 11577100}; # BioGrid 4263511 524 # CATALYTIC ACTIVITY ISCS_ECOLI L-cysteine + acceptor = L-alanine + S- sulfanyl-acceptor. {ECO 0000255|HAMAP-Rule MF_00331, ECO 0000269|PubMed 8663056}. # COFACTOR ISCS_ECOLI Name=pyridoxal 5'-phosphate; Xref=ChEBI CHEBI 597326; Evidence={ECO 0000255|HAMAP-Rule MF_00331, ECO 0000269|PubMed 10600118, ECO 0000269|PubMed 12860127}; # DISRUPTION PHENOTYPE ISCS_ECOLI Cells lacking this gene lose sulfurtransferase activity and require thiamine and nicotinic acid for growth. Under aerobic conditions the deletion of IscS causes an auxotrophy for thiamine and nicotinic acid, whereas under anaerobic conditions, only nicotinic acid s required. {ECO 0000269|PubMed 10781607, ECO 0000269|PubMed 10908675}. # DOMAIN ISCS_ECOLI The C-terminus (residues 376-404) is important for interaction with IscU. {ECO 0000269|PubMed 11577100}. # ENZYME REGULATION ISCS_ECOLI Treatment with N-ethylmaleimide inhibits sulfur transfer. Activated by ThiI and TusA. {ECO 0000269|PubMed 10600118, ECO 0000269|PubMed 11577100, ECO 0000269|PubMed 16387657}. # EcoGene EG12677 iscS # FUNCTION ISCS_ECOLI Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. Preferentially binds to disordered IscU on which the Fe-S is assembled, IscU converts to the structured state and then dissociates from IscS to transfer the Fe-S to an acceptor protein. Also functions as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate. Transfers sulfur onto 'Cys- 456' of ThiI and onto 'Cys-19' of TusA in transpersulfidation reactions. {ECO 0000269|PubMed 10544286, ECO 0000269|PubMed 10600118, ECO 0000269|PubMed 10781558, ECO 0000269|PubMed 10781607, ECO 0000269|PubMed 10829016, ECO 0000269|PubMed 10908675, ECO 0000269|PubMed 11577100, ECO 0000269|PubMed 16387657, ECO 0000269|PubMed 22203963, ECO 0000269|PubMed 8663056}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0009000 selenocysteine lyase activity; IDA:EcoCyc. # GO_function GO:0030170 pyridoxal phosphate binding; IDA:EcoCyc. # GO_function GO:0031071 cysteine desulfurase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051537 2 iron, 2 sulfur cluster binding; IEA:UniProtKB-HAMAP. # GO_function GO:0097163 sulfur carrier activity; EXP:EcoCyc. # GO_process GO:0016226 iron-sulfur cluster assembly; IMP:EcoCyc. # GO_process GO:0018131 oxazole or thiazole biosynthetic process; IMP:EcoCyc. # GO_process GO:0031119 tRNA pseudouridine synthesis; IDA:EcoCyc. # GO_process GO:0044571 [2Fe-2S] cluster assembly; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.640.10 -; 1. # Gene3D 3.90.1150.10 -; 1. # HAMAP MF_00331 Cys_desulf_IscS # INTERACTION ISCS_ECOLI P0ACD4 iscU; NbExp=8; IntAct=EBI-550055, EBI-561646; P52197 rhdA (xeno); NbExp=2; IntAct=EBI-550055, EBI-7906952; P0A890 tusA; NbExp=5; IntAct=EBI-550055, EBI-561780; # IntAct P0A6B7 45 # InterPro IPR000192 Aminotrans_V_dom # InterPro IPR010240 Cys_deSase_IscS # InterPro IPR015421 PyrdxlP-dep_Trfase_major_sub1 # InterPro IPR015422 PyrdxlP-dep_Trfase_major_sub2 # InterPro IPR015424 PyrdxlP-dep_Trfase # InterPro IPR016454 Cysteine_dSase # InterPro IPR020578 Aminotrans_V_PyrdxlP_BS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # KEGG_Pathway ko00730 Thiamine metabolism # KEGG_Pathway ko04122 Sulfur relay system # Organism ISCS_ECOLI Escherichia coli (strain K12) # PATHWAY ISCS_ECOLI Cofactor biosynthesis; iron-sulfur cluster biosynthesis. {ECO 0000255|HAMAP-Rule MF_00331, ECO 0000305|PubMed 10544286}. # PATRIC 32120457 VBIEscCol129921_2631 # PDB 1P3W X-ray; 2.10 A; A/B=1-404 # PIRSF PIRSF005572 NifS # PROSITE PS00595 AA_TRANSFER_CLASS_5 # Pfam PF00266 Aminotran_5 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ISCS_ECOLI Cysteine desulfurase IscS {ECO 0000255|HAMAP-Rule MF_00331, ECO 0000303|PubMed 8663056} # RefSeq WP_001295373 NZ_LN832404.1 # RefSeq YP_026169 NC_000913.3 # SIMILARITY Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. {ECO:0000255|HAMAP- Rule MF_00331}. # SUBCELLULAR LOCATION ISCS_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00331, ECO 0000305}. # SUBUNIT ISCS_ECOLI Homodimer. The homodimer interacts with IscU and TusA, other S acceptors. Each subunit of the IscS dimer contacts a IscU monomer. {ECO 0000269|PubMed 11577100, ECO 0000269|PubMed 12860127, ECO 0000269|PubMed 16387657, ECO 0000269|PubMed 22203963}. # SUPFAM SSF53383 SSF53383 # TIGRFAMs TIGR02006 IscS # eggNOG COG1104 LUCA # eggNOG ENOG4105C3J Bacteria BLAST swissprot:ISCS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ISCS_ECOLI BioCyc ECOL316407:JW2514-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2514-MONOMER BioCyc EcoCyc:G7325-MONOMER http://biocyc.org/getid?id=EcoCyc:G7325-MONOMER BioCyc MetaCyc:G7325-MONOMER http://biocyc.org/getid?id=MetaCyc:G7325-MONOMER COG COG1104 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1104 DIP DIP-29109N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-29109N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1016/S0022-2836(03)00690-9 http://dx.doi.org/10.1016/S0022-2836(03)00690-9 DOI 10.1016/j.molcel.2005.11.001 http://dx.doi.org/10.1016/j.molcel.2005.11.001 DOI 10.1021/bi991119r http://dx.doi.org/10.1021/bi991119r DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.1114372109 http://dx.doi.org/10.1073/pnas.1114372109 DOI 10.1073/pnas.160261497 http://dx.doi.org/10.1073/pnas.160261497 DOI 10.1074/jbc.M000926200 http://dx.doi.org/10.1074/jbc.M000926200 DOI 10.1074/jbc.M002680200 http://dx.doi.org/10.1074/jbc.M002680200 DOI 10.1074/jbc.M106907200 http://dx.doi.org/10.1074/jbc.M106907200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/oxfordjournals.jbchem.a022535 http://dx.doi.org/10.1093/oxfordjournals.jbchem.a022535 DOI 10.1093/oxfordjournals.jbchem.a022641 http://dx.doi.org/10.1093/oxfordjournals.jbchem.a022641 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.10.2879-2885.2000 http://dx.doi.org/10.1128/JB.182.10.2879-2885.2000 EC_number EC:2.8.1.7 {ECO:0000255|HAMAP-Rule:MF_00331, ECO:0000269|PubMed:8663056} http://www.genome.jp/dbget-bin/www_bget?EC:2.8.1.7 {ECO:0000255|HAMAP-Rule:MF_00331, ECO:0000269|PubMed:8663056} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.8.1.7 {ECO:0000255|HAMAP-Rule:MF_00331, ECO:0000269|PubMed:8663056} http://enzyme.expasy.org/EC/2.8.1.7 {ECO:0000255|HAMAP-Rule:MF_00331, ECO:0000269|PubMed:8663056} EchoBASE EB2542 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2542 EcoGene EG12677 http://www.ecogene.org/geneInfo.php?eg_id=EG12677 EnsemblBacteria AAT48142 http://www.ensemblgenomes.org/id/AAT48142 EnsemblBacteria AAT48142 http://www.ensemblgenomes.org/id/AAT48142 EnsemblBacteria BAA16424 http://www.ensemblgenomes.org/id/BAA16424 EnsemblBacteria BAA16424 http://www.ensemblgenomes.org/id/BAA16424 EnsemblBacteria BAA16424 http://www.ensemblgenomes.org/id/BAA16424 EnsemblBacteria b2530 http://www.ensemblgenomes.org/id/b2530 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0009000 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009000 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_function GO:0031071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031071 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051537 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051537 GO_function GO:0097163 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097163 GO_process GO:0016226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016226 GO_process GO:0018131 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018131 GO_process GO:0031119 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031119 GO_process GO:0044571 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044571 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.640.10 http://www.cathdb.info/version/latest/superfamily/3.40.640.10 Gene3D 3.90.1150.10 http://www.cathdb.info/version/latest/superfamily/3.90.1150.10 GeneID 947004 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947004 HAMAP MF_00331 http://hamap.expasy.org/unirule/MF_00331 HOGENOM HOG000017510 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000017510&db=HOGENOM6 InParanoid P0A6B7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6B7 IntAct P0A6B7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6B7* IntEnz 2.8.1.7 {ECO:0000255|HAMAP-Rule:MF_00331, ECO:0000269|PubMed:8663056} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.8.1.7 {ECO:0000255|HAMAP-Rule:MF_00331, ECO:0000269|PubMed:8663056} InterPro IPR000192 http://www.ebi.ac.uk/interpro/entry/IPR000192 InterPro IPR010240 http://www.ebi.ac.uk/interpro/entry/IPR010240 InterPro IPR015421 http://www.ebi.ac.uk/interpro/entry/IPR015421 InterPro IPR015422 http://www.ebi.ac.uk/interpro/entry/IPR015422 InterPro IPR015424 http://www.ebi.ac.uk/interpro/entry/IPR015424 InterPro IPR016454 http://www.ebi.ac.uk/interpro/entry/IPR016454 InterPro IPR020578 http://www.ebi.ac.uk/interpro/entry/IPR020578 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW2514 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2514 KEGG_Gene eco:b2530 http://www.genome.jp/dbget-bin/www_bget?eco:b2530 KEGG_Orthology KO:K04487 http://www.genome.jp/dbget-bin/www_bget?KO:K04487 KEGG_Pathway ko00730 http://www.genome.jp/kegg-bin/show_pathway?ko00730 KEGG_Pathway ko04122 http://www.genome.jp/kegg-bin/show_pathway?ko04122 KEGG_Reaction rn:R07460 http://www.genome.jp/dbget-bin/www_bget?rn:R07460 MINT MINT-236550 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-236550 OMA EPIQSGG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EPIQSGG PDB 1P3W http://www.ebi.ac.uk/pdbe-srv/view/entry/1P3W PDBsum 1P3W http://www.ebi.ac.uk/pdbsum/1P3W PROSITE PS00595 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00595 PSORT swissprot:ISCS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ISCS_ECOLI PSORT-B swissprot:ISCS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ISCS_ECOLI PSORT2 swissprot:ISCS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ISCS_ECOLI Pfam PF00266 http://pfam.xfam.org/family/PF00266 Phobius swissprot:ISCS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ISCS_ECOLI PhylomeDB P0A6B7 http://phylomedb.org/?seqid=P0A6B7 ProteinModelPortal P0A6B7 http://www.proteinmodelportal.org/query/uniprot/P0A6B7 PubMed 10544286 http://www.ncbi.nlm.nih.gov/pubmed/10544286 PubMed 10600118 http://www.ncbi.nlm.nih.gov/pubmed/10600118 PubMed 10739946 http://www.ncbi.nlm.nih.gov/pubmed/10739946 PubMed 10781558 http://www.ncbi.nlm.nih.gov/pubmed/10781558 PubMed 10781607 http://www.ncbi.nlm.nih.gov/pubmed/10781607 PubMed 10829016 http://www.ncbi.nlm.nih.gov/pubmed/10829016 PubMed 10908675 http://www.ncbi.nlm.nih.gov/pubmed/10908675 PubMed 11577100 http://www.ncbi.nlm.nih.gov/pubmed/11577100 PubMed 12860127 http://www.ncbi.nlm.nih.gov/pubmed/12860127 PubMed 16387657 http://www.ncbi.nlm.nih.gov/pubmed/16387657 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22203963 http://www.ncbi.nlm.nih.gov/pubmed/22203963 PubMed 8663056 http://www.ncbi.nlm.nih.gov/pubmed/8663056 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq WP_001295373 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295373 RefSeq YP_026169 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026169 SMR P0A6B7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6B7 STRING 511145.b2530 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2530&targetmode=cogs STRING COG1104 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1104&targetmode=cogs SUPFAM SSF53383 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53383 TIGRFAMs TIGR02006 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02006 UniProtKB ISCS_ECOLI http://www.uniprot.org/uniprot/ISCS_ECOLI UniProtKB-AC P0A6B7 http://www.uniprot.org/uniprot/P0A6B7 charge swissprot:ISCS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ISCS_ECOLI eggNOG COG1104 http://eggnogapi.embl.de/nog_data/html/tree/COG1104 eggNOG ENOG4105C3J http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C3J epestfind swissprot:ISCS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ISCS_ECOLI garnier swissprot:ISCS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ISCS_ECOLI helixturnhelix swissprot:ISCS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ISCS_ECOLI hmoment swissprot:ISCS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ISCS_ECOLI iep swissprot:ISCS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ISCS_ECOLI inforesidue swissprot:ISCS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ISCS_ECOLI octanol swissprot:ISCS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ISCS_ECOLI pepcoil swissprot:ISCS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ISCS_ECOLI pepdigest swissprot:ISCS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ISCS_ECOLI pepinfo swissprot:ISCS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ISCS_ECOLI pepnet swissprot:ISCS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ISCS_ECOLI pepstats swissprot:ISCS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ISCS_ECOLI pepwheel swissprot:ISCS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ISCS_ECOLI pepwindow swissprot:ISCS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ISCS_ECOLI sigcleave swissprot:ISCS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ISCS_ECOLI ## Database ID URL or Descriptions # AltName GFCD_ECOLI Group 4 capsule protein D homolog # BioGrid 4261409 172 # CAUTION In E.coli K12 / MG1655 and K12 / W3110 this operon is silenced by an IS1D insertion in the promoter region. {ECO 0000305}. # EcoGene EG13729 gfcD # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GOslim_component GO:0005886 plasma membrane # IntAct P75882 10 # InterPro IPR010344 YbjH # Organism GFCD_ECOLI Escherichia coli (strain K12) # PATRIC 32117191 VBIEscCol129921_1019 # PIR F64839 F64839 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF06082 YjbH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GFCD_ECOLI Uncharacterized lipoprotein GfcD # RefSeq NP_415504 NC_000913.3 # RefSeq WP_000742328 NZ_LN832404.1 # SUBCELLULAR LOCATION GFCD_ECOLI Cell membrane {ECO 0000305}; Lipid-anchor {ECO 0000305}. # TCDB 9.B.14.1.27 the putative heme handling protein (hhp) family # eggNOG ENOG4105E3R Bacteria # eggNOG ENOG410XQV2 LUCA BLAST swissprot:GFCD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GFCD_ECOLI BioCyc ECOL316407:JW0967-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0967-MONOMER BioCyc EcoCyc:G6505-MONOMER http://biocyc.org/getid?id=EcoCyc:G6505-MONOMER DIP DIP-12707N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12707N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3493 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3493 EcoGene EG13729 http://www.ecogene.org/geneInfo.php?eg_id=EG13729 EnsemblBacteria AAC74069 http://www.ensemblgenomes.org/id/AAC74069 EnsemblBacteria AAC74069 http://www.ensemblgenomes.org/id/AAC74069 EnsemblBacteria BAA35749 http://www.ensemblgenomes.org/id/BAA35749 EnsemblBacteria BAA35749 http://www.ensemblgenomes.org/id/BAA35749 EnsemblBacteria BAA35749 http://www.ensemblgenomes.org/id/BAA35749 EnsemblBacteria b0984 http://www.ensemblgenomes.org/id/b0984 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 945588 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945588 HOGENOM HOG000280356 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000280356&db=HOGENOM6 IntAct P75882 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75882* InterPro IPR010344 http://www.ebi.ac.uk/interpro/entry/IPR010344 KEGG_Gene ecj:JW0967 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0967 KEGG_Gene eco:b0984 http://www.genome.jp/dbget-bin/www_bget?eco:b0984 MINT MINT-1312700 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1312700 OMA WARYASE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WARYASE PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:GFCD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GFCD_ECOLI PSORT-B swissprot:GFCD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GFCD_ECOLI PSORT2 swissprot:GFCD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GFCD_ECOLI Pfam PF06082 http://pfam.xfam.org/family/PF06082 Phobius swissprot:GFCD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GFCD_ECOLI ProteinModelPortal P75882 http://www.proteinmodelportal.org/query/uniprot/P75882 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415504 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415504 RefSeq WP_000742328 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000742328 STRING 511145.b0984 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0984&targetmode=cogs TCDB 9.B.14.1.27 http://www.tcdb.org/search/result.php?tc=9.B.14.1.27 UniProtKB GFCD_ECOLI http://www.uniprot.org/uniprot/GFCD_ECOLI UniProtKB-AC P75882 http://www.uniprot.org/uniprot/P75882 charge swissprot:GFCD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GFCD_ECOLI eggNOG ENOG4105E3R http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E3R eggNOG ENOG410XQV2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQV2 epestfind swissprot:GFCD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GFCD_ECOLI garnier swissprot:GFCD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GFCD_ECOLI helixturnhelix swissprot:GFCD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GFCD_ECOLI hmoment swissprot:GFCD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GFCD_ECOLI iep swissprot:GFCD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GFCD_ECOLI inforesidue swissprot:GFCD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GFCD_ECOLI octanol swissprot:GFCD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GFCD_ECOLI pepcoil swissprot:GFCD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GFCD_ECOLI pepdigest swissprot:GFCD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GFCD_ECOLI pepinfo swissprot:GFCD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GFCD_ECOLI pepnet swissprot:GFCD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GFCD_ECOLI pepstats swissprot:GFCD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GFCD_ECOLI pepwheel swissprot:GFCD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GFCD_ECOLI pepwindow swissprot:GFCD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GFCD_ECOLI sigcleave swissprot:GFCD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GFCD_ECOLI ## Database ID URL or Descriptions # AltName YIAJ_ECOLI YiaKLMNOPQRS operon repressor # BioGrid 4259370 4 # EcoGene EG12278 yiaJ # FUNCTION YIAJ_ECOLI Negatively controls the transcription of the yiaKLMNOPQRS operon, which may be involved in the utilization of 2,3-diketo-L-gulonate. {ECO 0000269|PubMed 10913096}. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IBA:GO_Central. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # Gene3D 3.30.450.40 -; 1. # INDUCTION Expression of yiaJ is autogenously regulated and reduced by the binding of CRP-cAMP to the CRP site 1 of the YiaK-S promoter. {ECO:0000269|PubMed 10913096}. # IntAct P37671 3 # InterPro IPR005471 Tscrpt_reg_IclR_N # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR014757 Tscrpt_reg_IclR_C # InterPro IPR029016 GAF_dom-like # Organism YIAJ_ECOLI Escherichia coli (strain K12) # PATRIC 32122624 VBIEscCol129921_3689 # PDB 1YSQ X-ray; 1.75 A; A=94-282 # PIR S47795 S47795 # PROSITE PS51077 HTH_ICLR # PROSITE PS51078 ICLR_ED # Pfam PF01614 IclR # Pfam PF09339 HTH_IclR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIAJ_ECOLI HTH-type transcriptional regulator YiaJ # RefSeq NP_418031 NC_000913.3 # RefSeq WP_000514240 NZ_LN832404.1 # SIMILARITY Contains 1 HTH iclR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00393}. # SIMILARITY Contains 1 iclR-ED (iclR effector binding) domain. {ECO:0000255|PROSITE-ProRule PRU00394}. # SMART SM00346 HTH_ICLR # SUPFAM SSF46785 SSF46785 # SUPFAM SSF55781 SSF55781 # eggNOG COG1414 LUCA # eggNOG ENOG4105J4Q Bacteria BLAST swissprot:YIAJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIAJ_ECOLI BioCyc ECOL316407:JW3546-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3546-MONOMER BioCyc EcoCyc:EG12278-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12278-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.16.4617-4624.2000 http://dx.doi.org/10.1128/JB.182.16.4617-4624.2000 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2186 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2186 EcoGene EG12278 http://www.ecogene.org/geneInfo.php?eg_id=EG12278 EnsemblBacteria AAC76598 http://www.ensemblgenomes.org/id/AAC76598 EnsemblBacteria AAC76598 http://www.ensemblgenomes.org/id/AAC76598 EnsemblBacteria BAE77719 http://www.ensemblgenomes.org/id/BAE77719 EnsemblBacteria BAE77719 http://www.ensemblgenomes.org/id/BAE77719 EnsemblBacteria BAE77719 http://www.ensemblgenomes.org/id/BAE77719 EnsemblBacteria b3574 http://www.ensemblgenomes.org/id/b3574 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 3.30.450.40 http://www.cathdb.info/version/latest/superfamily/3.30.450.40 GeneID 948084 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948084 HOGENOM HOG000107041 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000107041&db=HOGENOM6 InParanoid P37671 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37671 IntAct P37671 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37671* InterPro IPR005471 http://www.ebi.ac.uk/interpro/entry/IPR005471 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR014757 http://www.ebi.ac.uk/interpro/entry/IPR014757 InterPro IPR029016 http://www.ebi.ac.uk/interpro/entry/IPR029016 KEGG_Gene ecj:JW3546 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3546 KEGG_Gene eco:b3574 http://www.genome.jp/dbget-bin/www_bget?eco:b3574 MINT MINT-1308441 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1308441 OMA HNKNSIT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HNKNSIT PDB 1YSQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1YSQ PDBsum 1YSQ http://www.ebi.ac.uk/pdbsum/1YSQ PROSITE PS51077 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51077 PROSITE PS51078 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51078 PSORT swissprot:YIAJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIAJ_ECOLI PSORT-B swissprot:YIAJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIAJ_ECOLI PSORT2 swissprot:YIAJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIAJ_ECOLI Pfam PF01614 http://pfam.xfam.org/family/PF01614 Pfam PF09339 http://pfam.xfam.org/family/PF09339 Phobius swissprot:YIAJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIAJ_ECOLI PhylomeDB P37671 http://phylomedb.org/?seqid=P37671 ProteinModelPortal P37671 http://www.proteinmodelportal.org/query/uniprot/P37671 PubMed 10913096 http://www.ncbi.nlm.nih.gov/pubmed/10913096 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418031 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418031 RefSeq WP_000514240 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000514240 SMART SM00346 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00346 SMR P37671 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37671 STRING 511145.b3574 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3574&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SUPFAM SSF55781 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55781 UniProtKB YIAJ_ECOLI http://www.uniprot.org/uniprot/YIAJ_ECOLI UniProtKB-AC P37671 http://www.uniprot.org/uniprot/P37671 charge swissprot:YIAJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIAJ_ECOLI eggNOG COG1414 http://eggnogapi.embl.de/nog_data/html/tree/COG1414 eggNOG ENOG4105J4Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105J4Q epestfind swissprot:YIAJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIAJ_ECOLI garnier swissprot:YIAJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIAJ_ECOLI helixturnhelix swissprot:YIAJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIAJ_ECOLI hmoment swissprot:YIAJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIAJ_ECOLI iep swissprot:YIAJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIAJ_ECOLI inforesidue swissprot:YIAJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIAJ_ECOLI octanol swissprot:YIAJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIAJ_ECOLI pepcoil swissprot:YIAJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIAJ_ECOLI pepdigest swissprot:YIAJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIAJ_ECOLI pepinfo swissprot:YIAJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIAJ_ECOLI pepnet swissprot:YIAJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIAJ_ECOLI pepstats swissprot:YIAJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIAJ_ECOLI pepwheel swissprot:YIAJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIAJ_ECOLI pepwindow swissprot:YIAJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIAJ_ECOLI sigcleave swissprot:YIAJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIAJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4260561 10 # COFACTOR YPDE_ECOLI Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000269|PubMed 15901689, ECO 0000305}; Name=Ni(2+); Xref=ChEBI CHEBI 49786; Evidence={ECO 0000269|PubMed 15901689, ECO 0000305}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 15901689, ECO 0000305}; Name=Cu(2+); Xref=ChEBI CHEBI 29036; Evidence={ECO 0000269|PubMed 15901689, ECO 0000305}; Note=Binds 2 divalent metal cations per subunit. Can use cobalt, and to a lesser extent, nickel, manganese or copper. {ECO 0000269|PubMed 15901689, ECO 0000305}; # EcoGene EG14152 ypdE # FUNCTION YPDE_ECOLI Has a broad aminopeptidase activity on non-blocked peptides by progressively cleaving amino acids off the peptide substrate. Aminopeptidase activity stops at the residue before the first proline in the peptide. Cannot cleave when proline is the first N-terminal residue. {ECO 0000269|PubMed 15901689}. # GO_function GO:0004177 aminopeptidase activity; IDA:EcoliWiki. # GO_function GO:0008237 metallopeptidase activity; IDA:EcoliWiki. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0043167 ion binding # Gene3D 2.40.30.40 -; 1. # IntAct P77585 8 # InterPro IPR008007 Peptidase_M42 # InterPro IPR023367 Peptidase_M42_dom2 # Organism YPDE_ECOLI Escherichia coli (strain K12) # PATRIC 32120147 VBIEscCol129921_2482 # PIR E65012 E65012 # PIRSF PIRSF001123 PepA_GA # Pfam PF05343 Peptidase_M42 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YPDE_ECOLI Aminopeptidase YpdE # RefSeq NP_416885 NC_000913.3 # RefSeq WP_000366028 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase M42 family. {ECO 0000305}. # eggNOG COG1363 LUCA # eggNOG ENOG4105CN9 Bacteria BLAST swissprot:YPDE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YPDE_ECOLI BioCyc ECOL316407:JW2381-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2381-MONOMER BioCyc EcoCyc:G7247-MONOMER http://biocyc.org/getid?id=EcoCyc:G7247-MONOMER BioCyc MetaCyc:G7247-MONOMER http://biocyc.org/getid?id=MetaCyc:G7247-MONOMER DIP DIP-48263N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48263N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.187.11.3671-3677.2005 http://dx.doi.org/10.1128/JB.187.11.3671-3677.2005 EC_number EC:3.4.11.- http://www.genome.jp/dbget-bin/www_bget?EC:3.4.11.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.4.11.- http://enzyme.expasy.org/EC/3.4.11.- EchoBASE EB3904 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3904 EcoGene EG14152 http://www.ecogene.org/geneInfo.php?eg_id=EG14152 EnsemblBacteria AAC75443 http://www.ensemblgenomes.org/id/AAC75443 EnsemblBacteria AAC75443 http://www.ensemblgenomes.org/id/AAC75443 EnsemblBacteria BAA16254 http://www.ensemblgenomes.org/id/BAA16254 EnsemblBacteria BAA16254 http://www.ensemblgenomes.org/id/BAA16254 EnsemblBacteria BAA16254 http://www.ensemblgenomes.org/id/BAA16254 EnsemblBacteria b2384 http://www.ensemblgenomes.org/id/b2384 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004177 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004177 GO_function GO:0008237 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008237 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 2.40.30.40 http://www.cathdb.info/version/latest/superfamily/2.40.30.40 GeneID 946848 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946848 HOGENOM HOG000291973 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000291973&db=HOGENOM6 InParanoid P77585 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77585 IntAct P77585 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77585* IntEnz 3.4.11 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.11 InterPro IPR008007 http://www.ebi.ac.uk/interpro/entry/IPR008007 InterPro IPR023367 http://www.ebi.ac.uk/interpro/entry/IPR023367 KEGG_Gene ecj:JW2381 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2381 KEGG_Gene eco:b2384 http://www.genome.jp/dbget-bin/www_bget?eco:b2384 OMA RILQHAT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RILQHAT PSORT swissprot:YPDE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YPDE_ECOLI PSORT-B swissprot:YPDE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YPDE_ECOLI PSORT2 swissprot:YPDE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YPDE_ECOLI Pfam PF05343 http://pfam.xfam.org/family/PF05343 Phobius swissprot:YPDE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YPDE_ECOLI PhylomeDB P77585 http://phylomedb.org/?seqid=P77585 ProteinModelPortal P77585 http://www.proteinmodelportal.org/query/uniprot/P77585 PubMed 15901689 http://www.ncbi.nlm.nih.gov/pubmed/15901689 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416885 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416885 RefSeq WP_000366028 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000366028 SMR P77585 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77585 STRING 511145.b2384 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2384&targetmode=cogs UniProtKB YPDE_ECOLI http://www.uniprot.org/uniprot/YPDE_ECOLI UniProtKB-AC P77585 http://www.uniprot.org/uniprot/P77585 charge swissprot:YPDE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YPDE_ECOLI eggNOG COG1363 http://eggnogapi.embl.de/nog_data/html/tree/COG1363 eggNOG ENOG4105CN9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CN9 epestfind swissprot:YPDE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YPDE_ECOLI garnier swissprot:YPDE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YPDE_ECOLI helixturnhelix swissprot:YPDE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YPDE_ECOLI hmoment swissprot:YPDE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YPDE_ECOLI iep swissprot:YPDE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YPDE_ECOLI inforesidue swissprot:YPDE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YPDE_ECOLI octanol swissprot:YPDE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YPDE_ECOLI pepcoil swissprot:YPDE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YPDE_ECOLI pepdigest swissprot:YPDE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YPDE_ECOLI pepinfo swissprot:YPDE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YPDE_ECOLI pepnet swissprot:YPDE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YPDE_ECOLI pepstats swissprot:YPDE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YPDE_ECOLI pepwheel swissprot:YPDE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YPDE_ECOLI pepwindow swissprot:YPDE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YPDE_ECOLI sigcleave swissprot:YPDE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YPDE_ECOLI ## Database ID URL or Descriptions # BioGrid 4263111 7 # CAUTION Was originally thought to be the small subunit of hydrogenase 2. {ECO:0000305|PubMed 8021226}. # COFACTOR HYBA_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000250}; Note=Binds 4 [4Fe-4S] clusters. {ECO 0000250}; # EcoGene EG11799 hybA # FUNCTION HYBA_ECOLI Participates in the periplasmic electron-transferring activity of hydrogenase 2 during its catalytic turnover. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_component GO:0005887 integral component of plasma membrane; ISM:EcoCyc. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_function GO:0016491 oxidoreductase activity; IEA:UniProtKB-KW. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0019588 anaerobic glycerol catabolic process; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # IntAct P0AAJ8 6 # InterPro IPR017896 4Fe4S_Fe-S-bd # InterPro IPR017900 4Fe4S_Fe_S_CS # InterPro IPR019546 TAT_signal_bac_arc # Organism HYBA_ECOLI Escherichia coli (strain K12) # PATRIC 32121408 VBIEscCol129921_3091 # PIR B65086 B65086 # PROSITE PS00198 4FE4S_FER_1 # PROSITE PS51379 4FE4S_FER_2; 3 # PTM HYBA_ECOLI Exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven. Can also be exported by the Sec system. # Pfam PF13247 Fer4_11 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HYBA_ECOLI Hydrogenase-2 operon protein HybA # RefSeq NP_417470 NC_000913.3 # RefSeq WP_001081870 NZ_LN832404.1 # SIMILARITY Contains 3 4Fe-4S ferredoxin-type domains. {ECO:0000255|PROSITE-ProRule PRU00711}. # SUBCELLULAR LOCATION HYBA_ECOLI Periplasm. # TIGRFAMs TIGR01409 TAT_signal_seq # eggNOG COG0437 LUCA # eggNOG ENOG4105QA4 Bacteria BLAST swissprot:HYBA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HYBA_ECOLI BioCyc ECOL316407:JW2964-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2964-MONOMER BioCyc EcoCyc:HYBA-MONOMER http://biocyc.org/getid?id=EcoCyc:HYBA-MONOMER BioCyc MetaCyc:HYBA-MONOMER http://biocyc.org/getid?id=MetaCyc:HYBA-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M610507200 http://dx.doi.org/10.1074/jbc.M610507200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U09177 http://www.ebi.ac.uk/ena/data/view/U09177 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB1747 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1747 EcoGene EG11799 http://www.ecogene.org/geneInfo.php?eg_id=EG11799 EnsemblBacteria AAC76032 http://www.ensemblgenomes.org/id/AAC76032 EnsemblBacteria AAC76032 http://www.ensemblgenomes.org/id/AAC76032 EnsemblBacteria BAE77057 http://www.ensemblgenomes.org/id/BAE77057 EnsemblBacteria BAE77057 http://www.ensemblgenomes.org/id/BAE77057 EnsemblBacteria BAE77057 http://www.ensemblgenomes.org/id/BAE77057 EnsemblBacteria b2996 http://www.ensemblgenomes.org/id/b2996 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0019588 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019588 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 944842 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944842 HOGENOM HOG000163383 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000163383&db=HOGENOM6 InParanoid P0AAJ8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAJ8 IntAct P0AAJ8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAJ8* InterPro IPR017896 http://www.ebi.ac.uk/interpro/entry/IPR017896 InterPro IPR017900 http://www.ebi.ac.uk/interpro/entry/IPR017900 InterPro IPR019546 http://www.ebi.ac.uk/interpro/entry/IPR019546 KEGG_Gene ecj:JW2964 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2964 KEGG_Gene eco:b2996 http://www.genome.jp/dbget-bin/www_bget?eco:b2996 OMA KYDYDNP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KYDYDNP PROSITE PS00198 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00198 PROSITE PS51379 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51379 PSORT swissprot:HYBA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HYBA_ECOLI PSORT-B swissprot:HYBA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HYBA_ECOLI PSORT2 swissprot:HYBA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HYBA_ECOLI Pfam PF13247 http://pfam.xfam.org/family/PF13247 Phobius swissprot:HYBA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HYBA_ECOLI PhylomeDB P0AAJ8 http://phylomedb.org/?seqid=P0AAJ8 ProteinModelPortal P0AAJ8 http://www.proteinmodelportal.org/query/uniprot/P0AAJ8 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17218314 http://www.ncbi.nlm.nih.gov/pubmed/17218314 PubMed 8021226 http://www.ncbi.nlm.nih.gov/pubmed/8021226 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417470 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417470 RefSeq WP_001081870 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001081870 STRING 511145.b2996 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2996&targetmode=cogs TIGRFAMs TIGR01409 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01409 UniProtKB HYBA_ECOLI http://www.uniprot.org/uniprot/HYBA_ECOLI UniProtKB-AC P0AAJ8 http://www.uniprot.org/uniprot/P0AAJ8 charge swissprot:HYBA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HYBA_ECOLI eggNOG COG0437 http://eggnogapi.embl.de/nog_data/html/tree/COG0437 eggNOG ENOG4105QA4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105QA4 epestfind swissprot:HYBA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HYBA_ECOLI garnier swissprot:HYBA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HYBA_ECOLI helixturnhelix swissprot:HYBA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HYBA_ECOLI hmoment swissprot:HYBA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HYBA_ECOLI iep swissprot:HYBA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HYBA_ECOLI inforesidue swissprot:HYBA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HYBA_ECOLI octanol swissprot:HYBA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HYBA_ECOLI pepcoil swissprot:HYBA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HYBA_ECOLI pepdigest swissprot:HYBA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HYBA_ECOLI pepinfo swissprot:HYBA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HYBA_ECOLI pepnet swissprot:HYBA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HYBA_ECOLI pepstats swissprot:HYBA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HYBA_ECOLI pepwheel swissprot:HYBA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HYBA_ECOLI pepwindow swissprot:HYBA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HYBA_ECOLI sigcleave swissprot:HYBA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HYBA_ECOLI ## Database ID URL or Descriptions # AltName 4'-phosphopantetheinyl transferase EntD {ECO:0000303|PubMed 9485415} # AltName Enterochelin synthase D {ECO:0000303|PubMed 9485415} # BIOPHYSICOCHEMICAL PROPERTIES ENTD_ECOLI Kinetic parameters KM=6.5 uM for EntB (at pH 7.5 and 37 degrees Celsius) {ECO 0000269|PubMed 9214294}; Note=Kcat is 5.1 min(-1) for transferase activity with EntB as substrate (at pH 7.5 and 37 degrees Celsius). {ECO 0000269|PubMed 9214294}; # BioGrid 4260709 77 # CATALYTIC ACTIVITY ENTD_ECOLI CoA + apo-EntB/F = adenosine 3',5'- bisphosphate + holo-EntB/F. {ECO 0000269|PubMed 9214294, ECO 0000269|PubMed 9485415}. # COFACTOR ENTD_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250|UniProtKB P24224}; # EcoGene EG10262 entD # FUNCTION ENTD_ECOLI Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3-dihydroxybenzoyl)-serine. The serine trilactone serves as a scaffolding for the three catechol functionalities that provide hexadentate coordination for the tightly ligated iron(2+) atoms. Plays an essential role in the assembly of the enterobactin by catalyzing the transfer of the 4'- phosphopantetheine (Ppant) moiety from coenzyme A to the apo- domains of both EntB (ArCP domain) and EntF (PCP domain) to yield their holo-forms which make them competent for the activation of 2,3-dihydroxybenzoate (DHB) and L-serine, respectively. {ECO 0000269|PubMed 8939709, ECO 0000269|PubMed 9214294, ECO 0000269|PubMed 9485415}. # GO_component GO:0005887 integral component of plasma membrane; ISM:EcoliWiki. # GO_component GO:0009366 enterobactin synthetase complex; IDA:EcoCyc. # GO_component GO:0031226 intrinsic component of plasma membrane; IDA:EcoliWiki. # GO_function GO:0000287 magnesium ion binding; IEA:InterPro. # GO_function GO:0008897 holo-[acyl-carrier-protein] synthase activity; IDA:EcoCyc. # GO_process GO:0009239 enterobactin biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0019748 secondary metabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.90.470.20 -; 2. # InterPro IPR003542 Enbac_synth_compD-like # InterPro IPR008278 4-PPantetheinyl_Trfase_SF # KEGG_Brite ko01000 Enzymes # MISCELLANEOUS Deletion of the C-terminal 25 residues of EntB results in very strong decrease of the catalytic efficiency of EntD. {ECO:0000269|PubMed 9214294}. # Organism ENTD_ECOLI Escherichia coli (strain K12) # PATHWAY Siderophore biosynthesis; enterobactin biosynthesis. {ECO:0000305|PubMed 9214294}. # PATRIC 32116336 VBIEscCol129921_0608 # PIR E64791 E64791 # PRINTS PR01399 ENTSNTHTASED # Pfam PF01648 ACPS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Enterobactin synthase component D {ECO:0000303|PubMed 9485415} # RefSeq NP_415115 NC_000913.3 # SEQUENCE CAUTION Sequence=AAB40782.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA35224.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=CAB57861.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; # SIMILARITY Belongs to the P-Pant transferase superfamily. EntD family. {ECO 0000305}. # SUBCELLULAR LOCATION ENTD_ECOLI Membrane {ECO 0000269|PubMed 2526281}. # SUBUNIT EntB, EntD, EntE, and EntF form a multienzyme complex called enterobactin synthase. {ECO:0000269|PubMed 9485415}. # SUPFAM SSF56214 SSF56214 # eggNOG COG2977 LUCA # eggNOG ENOG4108TSE Bacteria BLAST swissprot:ENTD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ENTD_ECOLI BioCyc ECOL316407:JW5085-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5085-MONOMER BioCyc EcoCyc:ENTD-MONOMER http://biocyc.org/getid?id=EcoCyc:ENTD-MONOMER BioCyc MetaCyc:ENTD-MONOMER http://biocyc.org/getid?id=MetaCyc:ENTD-MONOMER COG COG2977 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2977 DOI 10.1016/S1074-5521(96)90181-7 http://dx.doi.org/10.1016/S1074-5521(96)90181-7 DOI 10.1021/bi970453p http://dx.doi.org/10.1021/bi970453p DOI 10.1021/bi9726584 http://dx.doi.org/10.1021/bi9726584 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1099/00221287-135-11-3043 http://dx.doi.org/10.1099/00221287-135-11-3043 DOI 10.1111/j.1365-2958.1989.tb00224.x http://dx.doi.org/10.1111/j.1365-2958.1989.tb00224.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.8.- {ECO:0000269|PubMed:9214294, ECO:0000269|PubMed:9485415} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.8.- {ECO:0000269|PubMed:9214294, ECO:0000269|PubMed:9485415} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EMBL X17426 http://www.ebi.ac.uk/ena/data/view/X17426 ENZYME 2.7.8.- {ECO:0000269|PubMed:9214294, ECO:0000269|PubMed:9485415} http://enzyme.expasy.org/EC/2.7.8.- {ECO:0000269|PubMed:9214294, ECO:0000269|PubMed:9485415} EchoBASE EB0258 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0258 EcoGene EG10262 http://www.ecogene.org/geneInfo.php?eg_id=EG10262 EnsemblBacteria AAC73684 http://www.ensemblgenomes.org/id/AAC73684 EnsemblBacteria AAC73684 http://www.ensemblgenomes.org/id/AAC73684 EnsemblBacteria BAA35224 http://www.ensemblgenomes.org/id/BAA35224 EnsemblBacteria BAA35224 http://www.ensemblgenomes.org/id/BAA35224 EnsemblBacteria BAA35224 http://www.ensemblgenomes.org/id/BAA35224 EnsemblBacteria b0583 http://www.ensemblgenomes.org/id/b0583 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0009366 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009366 GO_component GO:0031226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031226 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0008897 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008897 GO_process GO:0009239 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009239 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0019748 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019748 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.90.470.20 http://www.cathdb.info/version/latest/superfamily/3.90.470.20 GeneID 945194 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945194 HOGENOM HOG000276815 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276815&db=HOGENOM6 InParanoid P19925 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P19925 IntAct P19925 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P19925* IntEnz 2.7.8.- {ECO:0000269|PubMed:9214294, ECO:0000269|PubMed:9485415} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.8.- {ECO:0000269|PubMed:9214294, ECO:0000269|PubMed:9485415} InterPro IPR003542 http://www.ebi.ac.uk/interpro/entry/IPR003542 InterPro IPR008278 http://www.ebi.ac.uk/interpro/entry/IPR008278 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5085 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5085 KEGG_Gene eco:b0583 http://www.genome.jp/dbget-bin/www_bget?eco:b0583 KEGG_Orthology KO:K02362 http://www.genome.jp/dbget-bin/www_bget?KO:K02362 PRINTS PR01399 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01399 PSORT swissprot:ENTD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ENTD_ECOLI PSORT-B swissprot:ENTD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ENTD_ECOLI PSORT2 swissprot:ENTD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ENTD_ECOLI Pfam PF01648 http://pfam.xfam.org/family/PF01648 Phobius swissprot:ENTD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ENTD_ECOLI ProteinModelPortal P19925 http://www.proteinmodelportal.org/query/uniprot/P19925 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2526281 http://www.ncbi.nlm.nih.gov/pubmed/2526281 PubMed 2533240 http://www.ncbi.nlm.nih.gov/pubmed/2533240 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 8939709 http://www.ncbi.nlm.nih.gov/pubmed/8939709 PubMed 9214294 http://www.ncbi.nlm.nih.gov/pubmed/9214294 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9485415 http://www.ncbi.nlm.nih.gov/pubmed/9485415 RefSeq NP_415115 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415115 SMR P19925 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P19925 STRING 511145.b0583 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0583&targetmode=cogs STRING COG2977 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2977&targetmode=cogs SUPFAM SSF56214 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56214 UniProtKB ENTD_ECOLI http://www.uniprot.org/uniprot/ENTD_ECOLI UniProtKB-AC P19925 http://www.uniprot.org/uniprot/P19925 charge swissprot:ENTD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ENTD_ECOLI eggNOG COG2977 http://eggnogapi.embl.de/nog_data/html/tree/COG2977 eggNOG ENOG4108TSE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108TSE epestfind swissprot:ENTD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ENTD_ECOLI garnier swissprot:ENTD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ENTD_ECOLI helixturnhelix swissprot:ENTD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ENTD_ECOLI hmoment swissprot:ENTD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ENTD_ECOLI iep swissprot:ENTD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ENTD_ECOLI inforesidue swissprot:ENTD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ENTD_ECOLI octanol swissprot:ENTD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ENTD_ECOLI pepcoil swissprot:ENTD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ENTD_ECOLI pepdigest swissprot:ENTD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ENTD_ECOLI pepinfo swissprot:ENTD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ENTD_ECOLI pepnet swissprot:ENTD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ENTD_ECOLI pepstats swissprot:ENTD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ENTD_ECOLI pepwheel swissprot:ENTD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ENTD_ECOLI pepwindow swissprot:ENTD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ENTD_ECOLI sigcleave swissprot:ENTD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ENTD_ECOLI ## Database ID URL or Descriptions # AltName Hibernation factor RMF {ECO:0000303|PubMed 22605777} # AltName RMF_ECOLI Protein E # BioGrid 4260019 268 # DISRUPTION PHENOTYPE RMF_ECOLI Non-essential gene, 100S ribosome dimers are not formed, decreased cell viability during stationary phase (PubMed 8440252). A quadruple raiA-hpf-rmf-sra knockout strain is significantly outcompeted by wild-type after 4 days growth (PubMed 17277072). Very high sensitivity to aminoglycoside antiobiotic gentamicin in stationary phase cultures (PubMed 26324267). {ECO 0000269|PubMed 17277072, ECO 0000269|PubMed 26324267, ECO 0000269|PubMed 8440252}. # EcoGene EG50004 rmf # FUNCTION RMF_ECOLI During stationary phase, converts 70S ribosomes to an immature dimeric form (90S ribosomes) which are converted to inactive 100S ribosomes (a process called ribosomal hibernation) by the hibernation promoting factor HPF (PubMed 7677746, PubMed 18174192). Inactivates ribosomes by covering the peptidyl transferase (PTase) center of the 23S rRNA and the entrance of peptide exit tunnel (PubMed 12473202, PubMed 15066119). However crystallization with T.thermophilus 70S ribosomes shows it binds near the 3'-end of the 16S rRNA near the anti-Shine-Dalgarno sequence, where it would sterically hinder translation inititation (PubMed 22605777). In this crystal binding of RMF induces movement of the 30S head domain away from the rest of the ribosome, presumably so they would more easily form dimers (PubMed 22605777). Also involved in protection against heat stress, but this role is not dependent on the maintenance of ribosome dimers (PubMed 15278243). {ECO 0000255|HAMAP- Rule MF_00919, ECO 0000269|PubMed 12473202, ECO 0000269|PubMed 15066119, ECO 0000269|PubMed 15278243, ECO 0000269|PubMed 18174192, ECO 0000269|PubMed 19170772, ECO 0000269|PubMed 7677746, ECO 0000269|PubMed 8440252, ECO 0000269|PubMed 9278503}. # GO_component GO:0005737 cytoplasm; IDA:EcoCyc. # GO_function GO:0019843 rRNA binding; IEA:UniProtKB-KW. # GO_function GO:0043022 ribosome binding; IDA:EcoCyc. # GO_function GO:0043024 ribosomal small subunit binding; IDA:EcoCyc. # GO_process GO:0032055 negative regulation of translation in response to stress; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0019843 rRNA binding # GOslim_process GO:0006950 response to stress # Gene3D 1.10.10.620 -; 1. # HAMAP MF_00919 RMF # INDUCTION RMF_ECOLI Induced during stationary growth phase (PubMed 8440252). Requires ppGpp for translation (PubMed 11532026). {ECO 0000255|HAMAP-Rule MF_00919, ECO 0000269|PubMed 11532026, ECO 0000269|PubMed 8440252}. # IntAct P0AFW2 3 # InterPro IPR007040 Ribosome_modulation_factor # InterPro IPR023200 Ribosome_modulation_factor_dom # KEGG_Brite ko03009 Ribosome biogenesis # MISCELLANEOUS When cells are transferred to rich nutritious culture medium, RMF is quickly released from 100S ribosomes, which dissociate into 70S ribosomes (PubMed:12473202). It indicates that this interconversion is a major system regulating translation activity during the transition of growth phases. {ECO 0000305|PubMed:12473202}. # Organism RMF_ECOLI Escherichia coli (strain K12) # PATRIC 32117125 VBIEscCol129921_0987 # PDB 4V8G X-ray; 3.00 A; AV/CV=1-55 # PIR H64835 H64835 # Pfam PF04957 RMF # ProDom PD051650 Ribosome_modulation_factor # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RMF_ECOLI Ribosome modulation factor {ECO 0000255|HAMAP-Rule MF_00919, ECO 0000303|PubMed 2181444} # RefSeq NP_415473 NC_000913.3 # RefSeq WP_000828648 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=J03186; Type=Frameshift; Positions=4, 11, 30; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ribosome modulation factor family. {ECO:0000255|HAMAP-Rule MF_00919}. # SUBCELLULAR LOCATION RMF_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT RMF_ECOLI Associates exclusively with 100S ribosomes (PubMed 2181444, PubMed 12473202, PubMed 15066119). Contacts 16S rRNA, might contact ribosomal protein S18 (PubMed 22605777). {ECO 0000269|PubMed 12473202, ECO 0000269|PubMed 15066119, ECO 0000269|PubMed 2181444, ECO 0000269|PubMed 22605777}. # eggNOG COG3130 LUCA # eggNOG ENOG4105WFT Bacteria BLAST swissprot:RMF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RMF_ECOLI BioCyc ECOL316407:JW0936-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0936-MONOMER BioCyc EcoCyc:EG50004-MONOMER http://biocyc.org/getid?id=EcoCyc:EG50004-MONOMER COG COG3130 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3130 DIP DIP-48260N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48260N DOI 10.1006/bbrc.1995.2302 http://dx.doi.org/10.1006/bbrc.1995.2302 DOI 10.1007/s00203-004-0698-9 http://dx.doi.org/10.1007/s00203-004-0698-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2443.2001.00457.x http://dx.doi.org/10.1046/j.1365-2443.2001.00457.x DOI 10.1073/pnas.87.7.2657 http://dx.doi.org/10.1073/pnas.87.7.2657 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/jb/mvm243 http://dx.doi.org/10.1093/jb/mvm243 DOI 10.1093/oxfordjournals.jbchem.a003313 http://dx.doi.org/10.1093/oxfordjournals.jbchem.a003313 DOI 10.1111/j.1356-9597.2004.00723.x http://dx.doi.org/10.1111/j.1356-9597.2004.00723.x DOI 10.1111/j.1365-2443.2008.01272.x http://dx.doi.org/10.1111/j.1365-2443.2008.01272.x DOI 10.1126/science.1218538 http://dx.doi.org/10.1126/science.1218538 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AAC.01532-15 http://dx.doi.org/10.1128/AAC.01532-15 DOI 10.1128/JB.01713-06 http://dx.doi.org/10.1128/JB.01713-06 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J03186 http://www.ebi.ac.uk/ena/data/view/J03186 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X70111 http://www.ebi.ac.uk/ena/data/view/X70111 EchoBASE EB4298 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4298 EcoGene EG50004 http://www.ecogene.org/geneInfo.php?eg_id=EG50004 EnsemblBacteria AAC74039 http://www.ensemblgenomes.org/id/AAC74039 EnsemblBacteria AAC74039 http://www.ensemblgenomes.org/id/AAC74039 EnsemblBacteria BAA35711 http://www.ensemblgenomes.org/id/BAA35711 EnsemblBacteria BAA35711 http://www.ensemblgenomes.org/id/BAA35711 EnsemblBacteria BAA35711 http://www.ensemblgenomes.org/id/BAA35711 EnsemblBacteria b0953 http://www.ensemblgenomes.org/id/b0953 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GO_function GO:0043022 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043022 GO_function GO:0043024 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043024 GO_process GO:0032055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032055 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 1.10.10.620 http://www.cathdb.info/version/latest/superfamily/1.10.10.620 GeneID 945567 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945567 HAMAP MF_00919 http://hamap.expasy.org/unirule/MF_00919 HOGENOM HOG000277840 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000277840&db=HOGENOM6 InParanoid P0AFW2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFW2 IntAct P0AFW2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFW2* InterPro IPR007040 http://www.ebi.ac.uk/interpro/entry/IPR007040 InterPro IPR023200 http://www.ebi.ac.uk/interpro/entry/IPR023200 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW0936 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0936 KEGG_Gene eco:b0953 http://www.genome.jp/dbget-bin/www_bget?eco:b0953 KEGG_Orthology KO:K03812 http://www.genome.jp/dbget-bin/www_bget?KO:K03812 OMA QRSHWLG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QRSHWLG PDB 4V8G http://www.ebi.ac.uk/pdbe-srv/view/entry/4V8G PDBsum 4V8G http://www.ebi.ac.uk/pdbsum/4V8G PSORT swissprot:RMF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RMF_ECOLI PSORT-B swissprot:RMF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RMF_ECOLI PSORT2 swissprot:RMF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RMF_ECOLI Pfam PF04957 http://pfam.xfam.org/family/PF04957 Phobius swissprot:RMF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RMF_ECOLI ProteinModelPortal P0AFW2 http://www.proteinmodelportal.org/query/uniprot/P0AFW2 PubMed 11532026 http://www.ncbi.nlm.nih.gov/pubmed/11532026 PubMed 12473202 http://www.ncbi.nlm.nih.gov/pubmed/12473202 PubMed 15066119 http://www.ncbi.nlm.nih.gov/pubmed/15066119 PubMed 15278243 http://www.ncbi.nlm.nih.gov/pubmed/15278243 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17277072 http://www.ncbi.nlm.nih.gov/pubmed/17277072 PubMed 18174192 http://www.ncbi.nlm.nih.gov/pubmed/18174192 PubMed 19170772 http://www.ncbi.nlm.nih.gov/pubmed/19170772 PubMed 2181444 http://www.ncbi.nlm.nih.gov/pubmed/2181444 PubMed 22605777 http://www.ncbi.nlm.nih.gov/pubmed/22605777 PubMed 26324267 http://www.ncbi.nlm.nih.gov/pubmed/26324267 PubMed 2832401 http://www.ncbi.nlm.nih.gov/pubmed/2832401 PubMed 7677746 http://www.ncbi.nlm.nih.gov/pubmed/7677746 PubMed 8440252 http://www.ncbi.nlm.nih.gov/pubmed/8440252 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415473 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415473 RefSeq WP_000828648 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000828648 SMR P0AFW2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFW2 STRING 511145.b0953 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0953&targetmode=cogs STRING COG3130 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3130&targetmode=cogs UniProtKB RMF_ECOLI http://www.uniprot.org/uniprot/RMF_ECOLI UniProtKB-AC P0AFW2 http://www.uniprot.org/uniprot/P0AFW2 charge swissprot:RMF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RMF_ECOLI eggNOG COG3130 http://eggnogapi.embl.de/nog_data/html/tree/COG3130 eggNOG ENOG4105WFT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105WFT epestfind swissprot:RMF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RMF_ECOLI garnier swissprot:RMF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RMF_ECOLI helixturnhelix swissprot:RMF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RMF_ECOLI hmoment swissprot:RMF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RMF_ECOLI iep swissprot:RMF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RMF_ECOLI inforesidue swissprot:RMF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RMF_ECOLI octanol swissprot:RMF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RMF_ECOLI pepcoil swissprot:RMF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RMF_ECOLI pepdigest swissprot:RMF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RMF_ECOLI pepinfo swissprot:RMF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RMF_ECOLI pepnet swissprot:RMF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RMF_ECOLI pepstats swissprot:RMF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RMF_ECOLI pepwheel swissprot:RMF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RMF_ECOLI pepwindow swissprot:RMF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RMF_ECOLI sigcleave swissprot:RMF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RMF_ECOLI ## Database ID URL or Descriptions # BioGrid 4263104 154 # EcoGene EG13312 ybgP # FUNCTION YBGP_ECOLI Could be required for the biogenesis of the putative YbgD fimbria. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IEA:InterPro. # GO_process GO:0006457 protein folding; IMP:EcoCyc. # GO_process GO:0043711 pilus organization; IEA:InterPro. # GO_process GO:0061077 chaperone-mediated protein folding; IEA:InterPro. # GO_process GO:0071555 cell wall organization; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0006457 protein folding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 2.60.40.1070 -; 1. # Gene3D 2.60.40.360 -; 1. # IntAct P75749 4 # InterPro IPR001829 Pili_assmbl_chaperone_bac # InterPro IPR008962 PapD-like # InterPro IPR016147 Pili_assmbl_chaperone_N # InterPro IPR016148 Pili_assmbl_chaperone_C # InterPro IPR018046 Pili_assmbl_chaperone_CS # Organism YBGP_ECOLI Escherichia coli (strain K12) # PATRIC 32116629 VBIEscCol129921_0747 # PIR D64807 D64807 # PRINTS PR00969 CHAPERONPILI # PROSITE PS00635 PILI_CHAPERONE # Pfam PF00345 PapD_N # Pfam PF02753 PapD_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBGP_ECOLI Uncharacterized fimbrial chaperone YbgP # RefSeq NP_415245 NC_000913.3 # RefSeq WP_000142799 NZ_LN832404.1 # SIMILARITY Belongs to the periplasmic pilus chaperone family. {ECO 0000305}. # SIMILARITY Contains 1 Ig-like (immunoglobulin-like) domain. {ECO 0000305}. # SUBCELLULAR LOCATION YBGP_ECOLI Periplasm {ECO 0000250}. # SUPFAM SSF49354 SSF49354 # SUPFAM SSF49584 SSF49584 # eggNOG ENOG4108TTM Bacteria # eggNOG ENOG4111FN8 LUCA BLAST swissprot:YBGP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBGP_ECOLI BioCyc ECOL316407:JW0707-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0707-MONOMER BioCyc EcoCyc:G6386-MONOMER http://biocyc.org/getid?id=EcoCyc:G6386-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3096 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3096 EcoGene EG13312 http://www.ecogene.org/geneInfo.php?eg_id=EG13312 EnsemblBacteria AAC73811 http://www.ensemblgenomes.org/id/AAC73811 EnsemblBacteria AAC73811 http://www.ensemblgenomes.org/id/AAC73811 EnsemblBacteria BAA35381 http://www.ensemblgenomes.org/id/BAA35381 EnsemblBacteria BAA35381 http://www.ensemblgenomes.org/id/BAA35381 EnsemblBacteria BAA35381 http://www.ensemblgenomes.org/id/BAA35381 EnsemblBacteria b0717 http://www.ensemblgenomes.org/id/b0717 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GO_process GO:0043711 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043711 GO_process GO:0061077 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061077 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 2.60.40.1070 http://www.cathdb.info/version/latest/superfamily/2.60.40.1070 Gene3D 2.60.40.360 http://www.cathdb.info/version/latest/superfamily/2.60.40.360 GeneID 945110 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945110 HOGENOM HOG000260153 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260153&db=HOGENOM6 IntAct P75749 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75749* InterPro IPR001829 http://www.ebi.ac.uk/interpro/entry/IPR001829 InterPro IPR008962 http://www.ebi.ac.uk/interpro/entry/IPR008962 InterPro IPR016147 http://www.ebi.ac.uk/interpro/entry/IPR016147 InterPro IPR016148 http://www.ebi.ac.uk/interpro/entry/IPR016148 InterPro IPR018046 http://www.ebi.ac.uk/interpro/entry/IPR018046 KEGG_Gene ecj:JW0707 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0707 KEGG_Gene eco:b0717 http://www.genome.jp/dbget-bin/www_bget?eco:b0717 OMA GALRMTM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GALRMTM PRINTS PR00969 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00969 PROSITE PS00635 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00635 PSORT swissprot:YBGP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBGP_ECOLI PSORT-B swissprot:YBGP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBGP_ECOLI PSORT2 swissprot:YBGP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBGP_ECOLI Pfam PF00345 http://pfam.xfam.org/family/PF00345 Pfam PF02753 http://pfam.xfam.org/family/PF02753 Phobius swissprot:YBGP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBGP_ECOLI PhylomeDB P75749 http://phylomedb.org/?seqid=P75749 ProteinModelPortal P75749 http://www.proteinmodelportal.org/query/uniprot/P75749 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415245 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415245 RefSeq WP_000142799 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000142799 SMR P75749 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75749 STRING 511145.b0717 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0717&targetmode=cogs SUPFAM SSF49354 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49354 SUPFAM SSF49584 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49584 UniProtKB YBGP_ECOLI http://www.uniprot.org/uniprot/YBGP_ECOLI UniProtKB-AC P75749 http://www.uniprot.org/uniprot/P75749 charge swissprot:YBGP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBGP_ECOLI eggNOG ENOG4108TTM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108TTM eggNOG ENOG4111FN8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111FN8 epestfind swissprot:YBGP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBGP_ECOLI garnier swissprot:YBGP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBGP_ECOLI helixturnhelix swissprot:YBGP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBGP_ECOLI hmoment swissprot:YBGP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBGP_ECOLI iep swissprot:YBGP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBGP_ECOLI inforesidue swissprot:YBGP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBGP_ECOLI octanol swissprot:YBGP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBGP_ECOLI pepcoil swissprot:YBGP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBGP_ECOLI pepdigest swissprot:YBGP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBGP_ECOLI pepinfo swissprot:YBGP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBGP_ECOLI pepnet swissprot:YBGP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBGP_ECOLI pepstats swissprot:YBGP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBGP_ECOLI pepwheel swissprot:YBGP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBGP_ECOLI pepwindow swissprot:YBGP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBGP_ECOLI sigcleave swissprot:YBGP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBGP_ECOLI ## Database ID URL or Descriptions # BioGrid 4261395 12 # EcoGene EG11876 yiiS # IntAct P32162 28 # InterPro IPR005272 CHP00743 # Organism YIIS_ECOLI Escherichia coli (strain K12) # PATRIC 32123357 VBIEscCol129921_4039 # PDB 2K3I NMR; -; A=1-99 # PIR S40865 S40865 # Pfam PF04175 DUF406 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIIS_ECOLI UPF0381 protein YiiS # RefSeq NP_418357 NC_000913.3 # RefSeq WP_000655989 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0381 family. {ECO 0000305}. # TIGRFAMs TIGR00743 TIGR00743 # eggNOG COG3691 LUCA # eggNOG ENOG41065TG Bacteria BLAST swissprot:YIIS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIIS_ECOLI BioCyc ECOL316407:JW3893-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3893-MONOMER BioCyc EcoCyc:EG11876-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11876-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1822 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1822 EcoGene EG11876 http://www.ecogene.org/geneInfo.php?eg_id=EG11876 EnsemblBacteria AAC76904 http://www.ensemblgenomes.org/id/AAC76904 EnsemblBacteria AAC76904 http://www.ensemblgenomes.org/id/AAC76904 EnsemblBacteria BAE77388 http://www.ensemblgenomes.org/id/BAE77388 EnsemblBacteria BAE77388 http://www.ensemblgenomes.org/id/BAE77388 EnsemblBacteria BAE77388 http://www.ensemblgenomes.org/id/BAE77388 EnsemblBacteria b3922 http://www.ensemblgenomes.org/id/b3922 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 948416 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948416 HOGENOM HOG000270330 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000270330&db=HOGENOM6 IntAct P32162 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32162* InterPro IPR005272 http://www.ebi.ac.uk/interpro/entry/IPR005272 KEGG_Gene ecj:JW3893 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3893 KEGG_Gene eco:b3922 http://www.genome.jp/dbget-bin/www_bget?eco:b3922 OMA GCAIDVG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GCAIDVG PDB 2K3I http://www.ebi.ac.uk/pdbe-srv/view/entry/2K3I PDBsum 2K3I http://www.ebi.ac.uk/pdbsum/2K3I PSORT swissprot:YIIS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIIS_ECOLI PSORT-B swissprot:YIIS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIIS_ECOLI PSORT2 swissprot:YIIS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIIS_ECOLI Pfam PF04175 http://pfam.xfam.org/family/PF04175 Phobius swissprot:YIIS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIIS_ECOLI ProteinModelPortal P32162 http://www.proteinmodelportal.org/query/uniprot/P32162 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418357 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418357 RefSeq WP_000655989 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000655989 SMR P32162 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32162 STRING 511145.b3922 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3922&targetmode=cogs TIGRFAMs TIGR00743 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00743 UniProtKB YIIS_ECOLI http://www.uniprot.org/uniprot/YIIS_ECOLI UniProtKB-AC P32162 http://www.uniprot.org/uniprot/P32162 charge swissprot:YIIS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIIS_ECOLI eggNOG COG3691 http://eggnogapi.embl.de/nog_data/html/tree/COG3691 eggNOG ENOG41065TG http://eggnogapi.embl.de/nog_data/html/tree/ENOG41065TG epestfind swissprot:YIIS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIIS_ECOLI garnier swissprot:YIIS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIIS_ECOLI helixturnhelix swissprot:YIIS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIIS_ECOLI hmoment swissprot:YIIS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIIS_ECOLI iep swissprot:YIIS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIIS_ECOLI inforesidue swissprot:YIIS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIIS_ECOLI octanol swissprot:YIIS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIIS_ECOLI pepcoil swissprot:YIIS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIIS_ECOLI pepdigest swissprot:YIIS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIIS_ECOLI pepinfo swissprot:YIIS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIIS_ECOLI pepnet swissprot:YIIS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIIS_ECOLI pepstats swissprot:YIIS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIIS_ECOLI pepwheel swissprot:YIIS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIIS_ECOLI pepwindow swissprot:YIIS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIIS_ECOLI sigcleave swissprot:YIIS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIIS_ECOLI ## Database ID URL or Descriptions # EcoGene EG14407 yjdP # Organism YJDP_ECOLI Escherichia coli (strain K12) # PATRIC 32123741 VBIEscCol129921_4219 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJDP_ECOLI Uncharacterized protein YjdP # RefSeq WP_000819746 NZ_LN832404.1 # RefSeq YP_026281 NC_000913.3 BLAST swissprot:YJDP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJDP_ECOLI BioCyc ECOL316407:JW5890-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5890-MONOMER BioCyc EcoCyc:MONOMER0-1541 http://biocyc.org/getid?id=EcoCyc:MONOMER0-1541 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14407 http://www.ecogene.org/geneInfo.php?eg_id=EG14407 EnsemblBacteria AAT48239 http://www.ensemblgenomes.org/id/AAT48239 EnsemblBacteria AAT48239 http://www.ensemblgenomes.org/id/AAT48239 EnsemblBacteria BAE78094 http://www.ensemblgenomes.org/id/BAE78094 EnsemblBacteria BAE78094 http://www.ensemblgenomes.org/id/BAE78094 EnsemblBacteria BAE78094 http://www.ensemblgenomes.org/id/BAE78094 EnsemblBacteria b4487 http://www.ensemblgenomes.org/id/b4487 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 2847754 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2847754 HOGENOM HOG000126975 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126975&db=HOGENOM6 KEGG_Gene ecj:JW5890 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5890 KEGG_Gene eco:b4487 http://www.genome.jp/dbget-bin/www_bget?eco:b4487 OMA WQREVND http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WQREVND PSORT swissprot:YJDP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJDP_ECOLI PSORT-B swissprot:YJDP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJDP_ECOLI PSORT2 swissprot:YJDP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJDP_ECOLI Phobius swissprot:YJDP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJDP_ECOLI ProteinModelPortal Q6BEX5 http://www.proteinmodelportal.org/query/uniprot/Q6BEX5 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000819746 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000819746 RefSeq YP_026281 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026281 UniProtKB YJDP_ECOLI http://www.uniprot.org/uniprot/YJDP_ECOLI UniProtKB-AC Q6BEX5 http://www.uniprot.org/uniprot/Q6BEX5 charge swissprot:YJDP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJDP_ECOLI epestfind swissprot:YJDP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJDP_ECOLI garnier swissprot:YJDP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJDP_ECOLI helixturnhelix swissprot:YJDP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJDP_ECOLI hmoment swissprot:YJDP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJDP_ECOLI iep swissprot:YJDP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJDP_ECOLI inforesidue swissprot:YJDP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJDP_ECOLI octanol swissprot:YJDP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJDP_ECOLI pepcoil swissprot:YJDP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJDP_ECOLI pepdigest swissprot:YJDP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJDP_ECOLI pepinfo swissprot:YJDP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJDP_ECOLI pepnet swissprot:YJDP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJDP_ECOLI pepstats swissprot:YJDP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJDP_ECOLI pepwheel swissprot:YJDP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJDP_ECOLI pepwindow swissprot:YJDP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJDP_ECOLI sigcleave swissprot:YJDP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJDP_ECOLI ## Database ID URL or Descriptions # BioGrid 4259665 7 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG14136 yfdL # Organism YFDL_ECOLI Escherichia coli (strain K12) # PATRIC 48664112 VBIEscCol107702_2396 # PIR H65008 H65008 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFDL_ECOLI Putative uncharacterized protein YfdL # SIMILARITY To E.coli YcfK and M.jannaschii MJ0347. {ECO 0000305}. BLAST swissprot:YFDL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFDL_ECOLI BioCyc ECOL316407:JW5384-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5384-MONOMER BioCyc EcoCyc:G7224-MONOMER http://biocyc.org/getid?id=EcoCyc:G7224-MONOMER DIP DIP-12000N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12000N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3888 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3888 EcoGene EG14136 http://www.ecogene.org/geneInfo.php?eg_id=EG14136 EnsemblBacteria BAE76695 http://www.ensemblgenomes.org/id/BAE76695 EnsemblBacteria BAE76695 http://www.ensemblgenomes.org/id/BAE76695 EnsemblBacteria BAE76695 http://www.ensemblgenomes.org/id/BAE76695 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv HOGENOM HOG000267967 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267967&db=HOGENOM6 InParanoid P76508 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76508 KEGG_Gene ecj:JW5384 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5384 PSORT swissprot:YFDL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFDL_ECOLI PSORT-B swissprot:YFDL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFDL_ECOLI PSORT2 swissprot:YFDL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFDL_ECOLI Phobius swissprot:YFDL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFDL_ECOLI PhylomeDB P76508 http://phylomedb.org/?seqid=P76508 ProteinModelPortal P76508 http://www.proteinmodelportal.org/query/uniprot/P76508 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 STRING 316407.85675369 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85675369&targetmode=cogs UniProtKB YFDL_ECOLI http://www.uniprot.org/uniprot/YFDL_ECOLI UniProtKB-AC P76508 http://www.uniprot.org/uniprot/P76508 charge swissprot:YFDL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFDL_ECOLI epestfind swissprot:YFDL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFDL_ECOLI garnier swissprot:YFDL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFDL_ECOLI helixturnhelix swissprot:YFDL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFDL_ECOLI hmoment swissprot:YFDL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFDL_ECOLI iep swissprot:YFDL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFDL_ECOLI inforesidue swissprot:YFDL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFDL_ECOLI octanol swissprot:YFDL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFDL_ECOLI pepcoil swissprot:YFDL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFDL_ECOLI pepdigest swissprot:YFDL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFDL_ECOLI pepinfo swissprot:YFDL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFDL_ECOLI pepnet swissprot:YFDL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFDL_ECOLI pepstats swissprot:YFDL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFDL_ECOLI pepwheel swissprot:YFDL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFDL_ECOLI pepwindow swissprot:YFDL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFDL_ECOLI sigcleave swissprot:YFDL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFDL_ECOLI ## Database ID URL or Descriptions # BioGrid 4260641 196 # DISRUPTION PHENOTYPE CRCB_ECOLI Mutants show increased sensitivity to fluoride (PubMed 22194412). Deletion of pagP (crcA), cspE and crcB increases sensitivity to camphor and exacerbates the nucleoid morphology defects of the topoisomerase IV temperature-sensitive mutants (PubMed 12904550). {ECO 0000269|PubMed 12904550, ECO 0000269|PubMed 22194412}. # EcoGene EG12209 crcB # FUNCTION CRCB_ECOLI Important for reducing fluoride concentration in the cell, thus reducing its toxicity. {ECO 0000255|HAMAP- Rule MF_00454, ECO 0000269|PubMed 22194412}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_function GO:0015103 inorganic anion transmembrane transporter activity; IMP:EcoCyc. # GO_function GO:1903425 fluoride transmembrane transporter activity; IBA:GO_Central. # GO_process GO:0015698 inorganic anion transport; IMP:EcoCyc. # GO_process GO:1903424 fluoride transmembrane transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # HAMAP MF_00454 CrcB # INDUCTION By fluoride, via a fluoride-responsive riboswitch. {ECO:0000269|PubMed 22194412}. # InterPro IPR003691 CrcB # MISCELLANEOUS CRCB_ECOLI Overexpression of pagP (crcA), cspE and crcB leads to camphor resistance, chromosome condensation and suppression of growth defects of mukB mutants (PubMed 8844142). Overexpression also increases levels of plasmid supercoiling, results in increased resistance to nalidixic acid in gyrase and topoisomerase IV temperature-sensitive mutants and affects the regulation of several genes (PubMed 12904550). {ECO 0000305|PubMed 12904550, ECO 0000305|PubMed 8844142}. # Organism CRCB_ECOLI Escherichia coli (strain K12) # PATRIC 32116428 VBIEscCol129921_0654 # PIR F64796 F64796 # Pfam PF02537 CRCB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Putative fluoride ion transporter CrcB {ECO:0000255|HAMAP-Rule MF_00454} # RefSeq NP_415157 NC_000913.3 # RefSeq WP_000939747 NZ_LN832404.1 # SIMILARITY Belongs to the CrcB (TC 9.B.71) family. {ECO:0000255|HAMAP-Rule MF_00454}. # SUBCELLULAR LOCATION CRCB_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_00454, ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 16429150}; Multi-pass membrane protein {ECO 0000255|HAMAP-Rule MF_00454, ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 16429150}. Note=Could be a dual-topology protein, which inserts into the membrane in two opposite orientations. May form an antiparallel homodimer in the inner membrane. # TCDB 1.A.43.1 the camphor resistance or fluoride exporter (fluc) family # TIGRFAMs TIGR00494 crcB # eggNOG COG0239 LUCA # eggNOG ENOG4107Z6W Bacteria BLAST swissprot:CRCB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CRCB_ECOLI BioCyc ECOL316407:JW0619-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0619-MONOMER BioCyc EcoCyc:EG12209-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12209-MONOMER BioCyc MetaCyc:EG12209-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12209-MONOMER COG COG0239 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0239 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsmb1057 http://dx.doi.org/10.1038/nsmb1057 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1099/mic.0.26363-0 http://dx.doi.org/10.1099/mic.0.26363-0 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.1215063 http://dx.doi.org/10.1126/science.1215063 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D28497 http://www.ebi.ac.uk/ena/data/view/D28497 EMBL S83396 http://www.ebi.ac.uk/ena/data/view/S83396 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB2123 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2123 EcoGene EG12209 http://www.ecogene.org/geneInfo.php?eg_id=EG12209 EnsemblBacteria AAC73725 http://www.ensemblgenomes.org/id/AAC73725 EnsemblBacteria AAC73725 http://www.ensemblgenomes.org/id/AAC73725 EnsemblBacteria BAA35267 http://www.ensemblgenomes.org/id/BAA35267 EnsemblBacteria BAA35267 http://www.ensemblgenomes.org/id/BAA35267 EnsemblBacteria BAA35267 http://www.ensemblgenomes.org/id/BAA35267 EnsemblBacteria b0624 http://www.ensemblgenomes.org/id/b0624 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015103 GO_function GO:1903425 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903425 GO_process GO:0015698 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015698 GO_process GO:1903424 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903424 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 945798 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945798 HAMAP MF_00454 http://hamap.expasy.org/unirule/MF_00454 HOGENOM HOG000052572 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000052572&db=HOGENOM6 InParanoid P37002 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37002 IntAct P37002 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37002* InterPro IPR003691 http://www.ebi.ac.uk/interpro/entry/IPR003691 KEGG_Gene ecj:JW0619 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0619 KEGG_Gene eco:b0624 http://www.genome.jp/dbget-bin/www_bget?eco:b0624 KEGG_Orthology KO:K06199 http://www.genome.jp/dbget-bin/www_bget?KO:K06199 OMA RFAITIG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RFAITIG PSORT swissprot:CRCB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CRCB_ECOLI PSORT-B swissprot:CRCB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CRCB_ECOLI PSORT2 swissprot:CRCB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CRCB_ECOLI Pfam PF02537 http://pfam.xfam.org/family/PF02537 Phobius swissprot:CRCB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CRCB_ECOLI PhylomeDB P37002 http://phylomedb.org/?seqid=P37002 ProteinModelPortal P37002 http://www.proteinmodelportal.org/query/uniprot/P37002 PubMed 12904550 http://www.ncbi.nlm.nih.gov/pubmed/12904550 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16429150 http://www.ncbi.nlm.nih.gov/pubmed/16429150 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22194412 http://www.ncbi.nlm.nih.gov/pubmed/22194412 PubMed 8844142 http://www.ncbi.nlm.nih.gov/pubmed/8844142 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415157 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415157 RefSeq WP_000939747 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000939747 SMR P37002 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37002 STRING 511145.b0624 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0624&targetmode=cogs STRING COG0239 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0239&targetmode=cogs TCDB 1.A.43.1 http://www.tcdb.org/search/result.php?tc=1.A.43.1 TIGRFAMs TIGR00494 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00494 UniProtKB CRCB_ECOLI http://www.uniprot.org/uniprot/CRCB_ECOLI UniProtKB-AC P37002 http://www.uniprot.org/uniprot/P37002 charge swissprot:CRCB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CRCB_ECOLI eggNOG COG0239 http://eggnogapi.embl.de/nog_data/html/tree/COG0239 eggNOG ENOG4107Z6W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107Z6W epestfind swissprot:CRCB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CRCB_ECOLI garnier swissprot:CRCB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CRCB_ECOLI helixturnhelix swissprot:CRCB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CRCB_ECOLI hmoment swissprot:CRCB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CRCB_ECOLI iep swissprot:CRCB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CRCB_ECOLI inforesidue swissprot:CRCB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CRCB_ECOLI octanol swissprot:CRCB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CRCB_ECOLI pepcoil swissprot:CRCB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CRCB_ECOLI pepdigest swissprot:CRCB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CRCB_ECOLI pepinfo swissprot:CRCB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CRCB_ECOLI pepnet swissprot:CRCB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CRCB_ECOLI pepstats swissprot:CRCB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CRCB_ECOLI pepwheel swissprot:CRCB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CRCB_ECOLI pepwindow swissprot:CRCB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CRCB_ECOLI sigcleave swissprot:CRCB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CRCB_ECOLI ## Database ID URL or Descriptions # AltName BDM_ECOLI Biofilm-dependent modulation protein # BioGrid 4260210 12 # EcoGene EG14301 bdm # GO_process GO:1902210 positive regulation of bacterial-type flagellum assembly; IMP:EcoCyc. # GOslim_process GO:0008150 biological_process # INDUCTION Expression is reduced in biofilms and is repressed by a high salt concentration. {ECO:0000269|PubMed 10498711}. # InterPro IPR019625 Biofilm-dep_modulation_Bdm_put # Organism BDM_ECOLI Escherichia coli (strain K12) # PATRIC 32118256 VBIEscCol129921_1548 # PIR D64901 D64901 # Pfam PF10684 BDM # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BDM_ECOLI Protein bdm # RefSeq NP_415998 NC_000913.3 # RefSeq WP_000495771 NZ_LN832404.1 # eggNOG ENOG4105TPS Bacteria # eggNOG ENOG4111V9Q LUCA BLAST swissprot:BDM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BDM_ECOLI BioCyc ECOL316407:JW5239-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5239-MONOMER BioCyc EcoCyc:G6776-MONOMER http://biocyc.org/getid?id=EcoCyc:G6776-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4048 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4048 EcoGene EG14301 http://www.ecogene.org/geneInfo.php?eg_id=EG14301 EnsemblBacteria AAC74554 http://www.ensemblgenomes.org/id/AAC74554 EnsemblBacteria AAC74554 http://www.ensemblgenomes.org/id/AAC74554 EnsemblBacteria BAE76453 http://www.ensemblgenomes.org/id/BAE76453 EnsemblBacteria BAE76453 http://www.ensemblgenomes.org/id/BAE76453 EnsemblBacteria BAE76453 http://www.ensemblgenomes.org/id/BAE76453 EnsemblBacteria b1481 http://www.ensemblgenomes.org/id/b1481 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:1902210 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902210 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 946041 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946041 HOGENOM HOG000120675 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120675&db=HOGENOM6 InParanoid P76127 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76127 InterPro IPR019625 http://www.ebi.ac.uk/interpro/entry/IPR019625 KEGG_Gene ecj:JW5239 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5239 KEGG_Gene eco:b1481 http://www.genome.jp/dbget-bin/www_bget?eco:b1481 OMA VVSGQHA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VVSGQHA PSORT swissprot:BDM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BDM_ECOLI PSORT-B swissprot:BDM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BDM_ECOLI PSORT2 swissprot:BDM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BDM_ECOLI Pfam PF10684 http://pfam.xfam.org/family/PF10684 Phobius swissprot:BDM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BDM_ECOLI ProteinModelPortal P76127 http://www.proteinmodelportal.org/query/uniprot/P76127 PubMed 10498711 http://www.ncbi.nlm.nih.gov/pubmed/10498711 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415998 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415998 RefSeq WP_000495771 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000495771 STRING 511145.b1481 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1481&targetmode=cogs UniProtKB BDM_ECOLI http://www.uniprot.org/uniprot/BDM_ECOLI UniProtKB-AC P76127 http://www.uniprot.org/uniprot/P76127 charge swissprot:BDM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BDM_ECOLI eggNOG ENOG4105TPS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105TPS eggNOG ENOG4111V9Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111V9Q epestfind swissprot:BDM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BDM_ECOLI garnier swissprot:BDM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BDM_ECOLI helixturnhelix swissprot:BDM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BDM_ECOLI hmoment swissprot:BDM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BDM_ECOLI iep swissprot:BDM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BDM_ECOLI inforesidue swissprot:BDM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BDM_ECOLI octanol swissprot:BDM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BDM_ECOLI pepcoil swissprot:BDM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BDM_ECOLI pepdigest swissprot:BDM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BDM_ECOLI pepinfo swissprot:BDM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BDM_ECOLI pepnet swissprot:BDM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BDM_ECOLI pepstats swissprot:BDM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BDM_ECOLI pepwheel swissprot:BDM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BDM_ECOLI pepwindow swissprot:BDM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BDM_ECOLI sigcleave swissprot:BDM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BDM_ECOLI ## Database ID URL or Descriptions # BioGrid 4260612 8 # EcoGene EG14225 yfiR # GO_process GO:0071978 bacterial-type flagellum-dependent swarming motility; IMP:EcoCyc. # GOslim_process GO:0048870 cell motility # IntAct P64548 2 # InterPro IPR025293 DUF4154 # Organism YFIR_ECOLI Escherichia coli (strain K12) # PATRIC 32120605 VBIEscCol129921_2701 # PIR F65038 F65038 # Pfam PF13689 DUF4154 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFIR_ECOLI Uncharacterized protein YfiR # RefSeq NP_417094 NC_000913.3 # RefSeq WP_001212391 NZ_LN832404.1 # eggNOG ENOG4108WS1 Bacteria # eggNOG ENOG4111MUY LUCA BLAST swissprot:YFIR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFIR_ECOLI BioCyc ECOL316407:JW2584-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2584-MONOMER BioCyc EcoCyc:G7354-MONOMER http://biocyc.org/getid?id=EcoCyc:G7354-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3977 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3977 EcoGene EG14225 http://www.ecogene.org/geneInfo.php?eg_id=EG14225 EnsemblBacteria AAC75652 http://www.ensemblgenomes.org/id/AAC75652 EnsemblBacteria AAC75652 http://www.ensemblgenomes.org/id/AAC75652 EnsemblBacteria BAE76756 http://www.ensemblgenomes.org/id/BAE76756 EnsemblBacteria BAE76756 http://www.ensemblgenomes.org/id/BAE76756 EnsemblBacteria BAE76756 http://www.ensemblgenomes.org/id/BAE76756 EnsemblBacteria b2603 http://www.ensemblgenomes.org/id/b2603 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0071978 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071978 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 GeneID 947090 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947090 HOGENOM HOG000217427 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000217427&db=HOGENOM6 InParanoid P64548 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P64548 IntAct P64548 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P64548* InterPro IPR025293 http://www.ebi.ac.uk/interpro/entry/IPR025293 KEGG_Gene ecj:JW2584 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2584 KEGG_Gene eco:b2603 http://www.genome.jp/dbget-bin/www_bget?eco:b2603 OMA EADDPCT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EADDPCT PSORT swissprot:YFIR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFIR_ECOLI PSORT-B swissprot:YFIR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFIR_ECOLI PSORT2 swissprot:YFIR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFIR_ECOLI Pfam PF13689 http://pfam.xfam.org/family/PF13689 Phobius swissprot:YFIR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFIR_ECOLI ProteinModelPortal P64548 http://www.proteinmodelportal.org/query/uniprot/P64548 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417094 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417094 RefSeq WP_001212391 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001212391 SMR P64548 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P64548 STRING 511145.b2603 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2603&targetmode=cogs UniProtKB YFIR_ECOLI http://www.uniprot.org/uniprot/YFIR_ECOLI UniProtKB-AC P64548 http://www.uniprot.org/uniprot/P64548 charge swissprot:YFIR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFIR_ECOLI eggNOG ENOG4108WS1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108WS1 eggNOG ENOG4111MUY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111MUY epestfind swissprot:YFIR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFIR_ECOLI garnier swissprot:YFIR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFIR_ECOLI helixturnhelix swissprot:YFIR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFIR_ECOLI hmoment swissprot:YFIR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFIR_ECOLI iep swissprot:YFIR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFIR_ECOLI inforesidue swissprot:YFIR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFIR_ECOLI octanol swissprot:YFIR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFIR_ECOLI pepcoil swissprot:YFIR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFIR_ECOLI pepdigest swissprot:YFIR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFIR_ECOLI pepinfo swissprot:YFIR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFIR_ECOLI pepnet swissprot:YFIR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFIR_ECOLI pepstats swissprot:YFIR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFIR_ECOLI pepwheel swissprot:YFIR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFIR_ECOLI pepwindow swissprot:YFIR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFIR_ECOLI sigcleave swissprot:YFIR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFIR_ECOLI ## Database ID URL or Descriptions # DISRUPTION PHENOTYPE Cells lacking this gene are viable with no apparent phenotype, but they are affected in the insertion and processing of three YidC-dependent inner membrane proteins. {ECO:0000269|PubMed 21803992}. # EcoGene EG11348 yidD # FUNCTION YIDD_ECOLI Could be involved in insertion of integral membrane proteins into the membrane. {ECO 0000255|HAMAP-Rule MF_00386, ECO 0000269|PubMed 21803992}. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_function GO:0032977 membrane insertase activity; IMP:EcoCyc. # GO_process GO:0051205 protein insertion into membrane; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0008565 protein transporter activity # GOslim_process GO:0008150 biological_process # HAMAP MF_00386 UPF0161_YidD # InterPro IPR002696 Membr_insert_effic_factor # Organism YIDD_ECOLI Escherichia coli (strain K12) # Pfam PF01809 Haemolytic # ProDom PD004225 DUF37 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Putative membrane protein insertion efficiency factor {ECO:0000255|HAMAP-Rule MF_00386} # RefSeq WP_001307474 NZ_LN832404.1 # RefSeq YP_588472 NC_000913.3 # SIMILARITY Belongs to the UPF0161 family. {ECO:0000255|HAMAP- Rule MF_00386}. # SMART SM01234 Haemolytic # SUBCELLULAR LOCATION YIDD_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_00386, ECO 0000269|PubMed 21803992}; Peripheral membrane protein {ECO 0000255|HAMAP-Rule MF_00386, ECO 0000269|PubMed 21803992}; Cytoplasmic side {ECO 0000255|HAMAP- Rule MF_00386, ECO 0000269|PubMed 21803992}. Note=Associated with the inner membrane via a putative N-terminal amphipathic helix. # TIGRFAMs TIGR00278 TIGR00278 # eggNOG COG0759 LUCA # eggNOG ENOG4105VAS Bacteria BLAST swissprot:YIDD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIDD_ECOLI BioCyc ECOL316407:JW3682-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3682-MONOMER BioCyc EcoCyc:MONOMER0-2692 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2692 COG COG0759 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0759 DOI 10.1016/0378-1119(85)90206-9 http://dx.doi.org/10.1016/0378-1119(85)90206-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.05429-11 http://dx.doi.org/10.1128/JB.05429-11 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M11056 http://www.ebi.ac.uk/ena/data/view/M11056 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1324 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1324 EcoGene EG11348 http://www.ecogene.org/geneInfo.php?eg_id=EG11348 EnsemblBacteria ABD18707 http://www.ensemblgenomes.org/id/ABD18707 EnsemblBacteria ABD18707 http://www.ensemblgenomes.org/id/ABD18707 EnsemblBacteria BAE77589 http://www.ensemblgenomes.org/id/BAE77589 EnsemblBacteria BAE77589 http://www.ensemblgenomes.org/id/BAE77589 EnsemblBacteria BAE77589 http://www.ensemblgenomes.org/id/BAE77589 EnsemblBacteria b4557 http://www.ensemblgenomes.org/id/b4557 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0032977 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032977 GO_process GO:0051205 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051205 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 1450303 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1450303 HAMAP MF_00386 http://hamap.expasy.org/unirule/MF_00386 HOGENOM HOG000231600 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231600&db=HOGENOM6 InParanoid P0A8C8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8C8 InterPro IPR002696 http://www.ebi.ac.uk/interpro/entry/IPR002696 KEGG_Gene ecj:JW3682 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3682 KEGG_Gene eco:b4557 http://www.genome.jp/dbget-bin/www_bget?eco:b4557 KEGG_Orthology KO:K08998 http://www.genome.jp/dbget-bin/www_bget?KO:K08998 OMA RCQPFHP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RCQPFHP PSORT swissprot:YIDD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIDD_ECOLI PSORT-B swissprot:YIDD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIDD_ECOLI PSORT2 swissprot:YIDD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIDD_ECOLI Pfam PF01809 http://pfam.xfam.org/family/PF01809 Phobius swissprot:YIDD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIDD_ECOLI PhylomeDB P0A8C8 http://phylomedb.org/?seqid=P0A8C8 ProteinModelPortal P0A8C8 http://www.proteinmodelportal.org/query/uniprot/P0A8C8 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21803992 http://www.ncbi.nlm.nih.gov/pubmed/21803992 PubMed 2415431 http://www.ncbi.nlm.nih.gov/pubmed/2415431 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001307474 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001307474 RefSeq YP_588472 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_588472 SMART SM01234 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01234 STRING 511145.b4557 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4557&targetmode=cogs STRING COG0759 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0759&targetmode=cogs TIGRFAMs TIGR00278 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00278 UniProtKB YIDD_ECOLI http://www.uniprot.org/uniprot/YIDD_ECOLI UniProtKB-AC P0A8C8 http://www.uniprot.org/uniprot/P0A8C8 charge swissprot:YIDD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIDD_ECOLI eggNOG COG0759 http://eggnogapi.embl.de/nog_data/html/tree/COG0759 eggNOG ENOG4105VAS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VAS epestfind swissprot:YIDD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIDD_ECOLI garnier swissprot:YIDD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIDD_ECOLI helixturnhelix swissprot:YIDD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIDD_ECOLI hmoment swissprot:YIDD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIDD_ECOLI iep swissprot:YIDD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIDD_ECOLI inforesidue swissprot:YIDD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIDD_ECOLI octanol swissprot:YIDD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIDD_ECOLI pepcoil swissprot:YIDD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIDD_ECOLI pepdigest swissprot:YIDD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIDD_ECOLI pepinfo swissprot:YIDD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIDD_ECOLI pepnet swissprot:YIDD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIDD_ECOLI pepstats swissprot:YIDD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIDD_ECOLI pepwheel swissprot:YIDD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIDD_ECOLI pepwindow swissprot:YIDD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIDD_ECOLI sigcleave swissprot:YIDD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIDD_ECOLI ## Database ID URL or Descriptions # EcoGene EG40003 insC3 # FUNCTION INSC3_ECOLI Involved in the transposition of the insertion sequence IS2. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 1.10.10.60 -; 1. # InterPro IPR002514 Transposase_8 # InterPro IPR009057 Homeodomain-like # Organism INSC3_ECOLI Escherichia coli (strain K12) # PIR B65240 B65240 # Pfam PF01527 HTH_Tnp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSC3_ECOLI Transposase InsC for insertion element IS2F # RefSeq NP_414894 NC_000913.3 # RefSeq NP_415921 NC_000913.3 # RefSeq NP_417338 NC_000913.3 # RefSeq NP_417516 NC_000913.3 # RefSeq NP_418692 NC_000913.3 # RefSeq WP_000567766 NZ_LN832404.1 # RefSeq YP_026163 NC_000913.3 # SEQUENCE CAUTION Sequence=BAA15822.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the transposase 8 family. {ECO 0000305}. # SUPFAM SSF46689 SSF46689 # eggNOG COG2963 LUCA # eggNOG ENOG4108ZQS Bacteria BLAST swissprot:INSC3_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSC3_ECOLI BioCyc EcoCyc:MONOMER0-4251 http://biocyc.org/getid?id=EcoCyc:MONOMER0-4251 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4732 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4732 EcoGene EG40003 http://www.ecogene.org/geneInfo.php?eg_id=EG40003 EnsemblBacteria AAT48140 http://www.ensemblgenomes.org/id/AAT48140 EnsemblBacteria AAT48140 http://www.ensemblgenomes.org/id/AAT48140 EnsemblBacteria BAA15822 http://www.ensemblgenomes.org/id/BAA15822 EnsemblBacteria BAA15822 http://www.ensemblgenomes.org/id/BAA15822 EnsemblBacteria BAA15822 http://www.ensemblgenomes.org/id/BAA15822 EnsemblBacteria b1997 http://www.ensemblgenomes.org/id/b1997 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 GeneID 945025 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945025 GeneID 945967 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945967 GeneID 946455 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946455 GeneID 947347 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947347 GeneID 947520 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947520 GeneID 948781 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948781 InParanoid P0CF42 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CF42 InterPro IPR002514 http://www.ebi.ac.uk/interpro/entry/IPR002514 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 KEGG_Gene ecj:JW1978 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1978 KEGG_Gene eco:b0360 http://www.genome.jp/dbget-bin/www_bget?eco:b0360 KEGG_Gene eco:b1403 http://www.genome.jp/dbget-bin/www_bget?eco:b1403 KEGG_Gene eco:b1997 http://www.genome.jp/dbget-bin/www_bget?eco:b1997 KEGG_Gene eco:b2861 http://www.genome.jp/dbget-bin/www_bget?eco:b2861 KEGG_Gene eco:b3044 http://www.genome.jp/dbget-bin/www_bget?eco:b3044 KEGG_Gene eco:b4272 http://www.genome.jp/dbget-bin/www_bget?eco:b4272 PSORT swissprot:INSC3_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSC3_ECOLI PSORT-B swissprot:INSC3_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSC3_ECOLI PSORT2 swissprot:INSC3_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSC3_ECOLI Pfam PF01527 http://pfam.xfam.org/family/PF01527 Phobius swissprot:INSC3_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSC3_ECOLI PhylomeDB P0CF42 http://phylomedb.org/?seqid=P0CF42 ProteinModelPortal P0CF42 http://www.proteinmodelportal.org/query/uniprot/P0CF42 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414894 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414894 RefSeq NP_415921 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415921 RefSeq NP_417338 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417338 RefSeq NP_417516 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417516 RefSeq NP_418692 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418692 RefSeq WP_000567766 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000567766 RefSeq YP_026163 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026163 STRING 511145.b4272 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4272&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 UniProtKB INSC3_ECOLI http://www.uniprot.org/uniprot/INSC3_ECOLI UniProtKB-AC P0CF42 http://www.uniprot.org/uniprot/P0CF42 charge swissprot:INSC3_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSC3_ECOLI eggNOG COG2963 http://eggnogapi.embl.de/nog_data/html/tree/COG2963 eggNOG ENOG4108ZQS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZQS epestfind swissprot:INSC3_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSC3_ECOLI garnier swissprot:INSC3_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSC3_ECOLI helixturnhelix swissprot:INSC3_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSC3_ECOLI hmoment swissprot:INSC3_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSC3_ECOLI iep swissprot:INSC3_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSC3_ECOLI inforesidue swissprot:INSC3_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSC3_ECOLI octanol swissprot:INSC3_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSC3_ECOLI pepcoil swissprot:INSC3_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSC3_ECOLI pepdigest swissprot:INSC3_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSC3_ECOLI pepinfo swissprot:INSC3_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSC3_ECOLI pepnet swissprot:INSC3_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSC3_ECOLI pepstats swissprot:INSC3_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSC3_ECOLI pepwheel swissprot:INSC3_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSC3_ECOLI pepwindow swissprot:INSC3_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSC3_ECOLI sigcleave swissprot:INSC3_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSC3_ECOLI ## Database ID URL or Descriptions # AltName PAAI_ECOLI Phenylacetic acid degradation protein PaaI # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=16 uM for 3,4-dihydroxyphenylacetyl-CoA; KM=21 uM for 3-hydroxyphenylacetyl-CoA; KM=35 uM for 4-hydroxyphenylacetyl-CoA; pH dependence Optimum pH is 7.5-9.; # BRENDA 3.1.2.B5 2026 # BioGrid 4261735 619 # EcoGene EG13743 paaI # FUNCTION PAAI_ECOLI Thioesterase with a preference for ring-hydroxylated phenylacetyl-CoA esters. Hydrolyzes 3,4-dihydroxyphenylacetyl-CoA, 3-hydroxyphenylacetyl-CoA and 4-hydroxyphenylacetyl-CoA. Inactive towards 4-hydroxybenzoyl-CoA and 4-hydroxyphenacyl-CoA. {ECO 0000269|PubMed 16464851, ECO 0000269|PubMed 9748275}. # GO_function GO:0016289 CoA hydrolase activity; IDA:EcoCyc. # GO_process GO:0010124 phenylacetate catabolic process; IEA:UniProtKB-UniPathway. # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.10.129.10 -; 1. # INDUCTION PAAI_ECOLI Activated by cAMP receptor protein (CRP), integration host factor (IHF) and by phenylacetyl-coenzyme A (PA-CoA) that prevents PaaX from binding its target sequences. Inhibited by PaaX. {ECO 0000269|PubMed 10766858, ECO 0000269|PubMed 9748275}. # IntAct P76084 2 # InterPro IPR003736 PAAI_dom # InterPro IPR006683 Thioestr_dom # InterPro IPR011973 PaaD # InterPro IPR029069 HotDog_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00360 Phenylalanine metabolism # MASS SPECTROMETRY Mass=14720; Method=Electrospray; Range=2-140; Evidence={ECO:0000269|PubMed 16464851}; # Organism PAAI_ECOLI Escherichia coli (strain K12) # PATHWAY PAAI_ECOLI Aromatic compound metabolism; phenylacetate degradation. # PATRIC 32118078 VBIEscCol129921_1459 # PDB 1PSU X-ray; 2.20 A; A/B=1-140 # PDB 2FS2 X-ray; 2.00 A; A/B=2-140 # PIR G64890 G64890 # Pfam PF03061 4HBT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PAAI_ECOLI Acyl-coenzyme A thioesterase PaaI # RefSeq NP_415914 NC_000913.3 # RefSeq WP_000018413 NZ_LN832404.1 # SIMILARITY Belongs to the thioesterase PaaI family. {ECO 0000305}. # SUBUNIT Homotetramer. {ECO:0000269|PubMed 16464851}. # SUPFAM SSF54637 SSF54637 # TIGRFAMs TIGR00369 unchar_dom_1 # TIGRFAMs TIGR02286 PaaD # eggNOG COG2050 LUCA # eggNOG ENOG4108ZJI Bacteria BLAST swissprot:PAAI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PAAI_ECOLI BioCyc ECOL316407:JW1391-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1391-MONOMER BioCyc EcoCyc:G6717-MONOMER http://biocyc.org/getid?id=EcoCyc:G6717-MONOMER BioCyc MetaCyc:G6717-MONOMER http://biocyc.org/getid?id=MetaCyc:G6717-MONOMER COG COG2050 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2050 DIP DIP-10428N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10428N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.273.40.25974 http://dx.doi.org/10.1074/jbc.273.40.25974 DOI 10.1074/jbc.275.16.12214 http://dx.doi.org/10.1074/jbc.275.16.12214 DOI 10.1074/jbc.M513896200 http://dx.doi.org/10.1074/jbc.M513896200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.2.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.2.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X97452 http://www.ebi.ac.uk/ena/data/view/X97452 ENZYME 3.1.2.- http://enzyme.expasy.org/EC/3.1.2.- EchoBASE EB3506 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3506 EcoGene EG13743 http://www.ecogene.org/geneInfo.php?eg_id=EG13743 EnsemblBacteria AAC74478 http://www.ensemblgenomes.org/id/AAC74478 EnsemblBacteria AAC74478 http://www.ensemblgenomes.org/id/AAC74478 EnsemblBacteria BAE76427 http://www.ensemblgenomes.org/id/BAE76427 EnsemblBacteria BAE76427 http://www.ensemblgenomes.org/id/BAE76427 EnsemblBacteria BAE76427 http://www.ensemblgenomes.org/id/BAE76427 EnsemblBacteria b1396 http://www.ensemblgenomes.org/id/b1396 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016289 GO_process GO:0010124 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010124 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.10.129.10 http://www.cathdb.info/version/latest/superfamily/3.10.129.10 GeneID 945265 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945265 HOGENOM HOG000066992 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000066992&db=HOGENOM6 InParanoid P76084 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76084 IntAct P76084 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76084* IntEnz 3.1.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.2 InterPro IPR003736 http://www.ebi.ac.uk/interpro/entry/IPR003736 InterPro IPR006683 http://www.ebi.ac.uk/interpro/entry/IPR006683 InterPro IPR011973 http://www.ebi.ac.uk/interpro/entry/IPR011973 InterPro IPR029069 http://www.ebi.ac.uk/interpro/entry/IPR029069 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1391 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1391 KEGG_Gene eco:b1396 http://www.genome.jp/dbget-bin/www_bget?eco:b1396 KEGG_Orthology KO:K02614 http://www.genome.jp/dbget-bin/www_bget?KO:K02614 KEGG_Pathway ko00360 http://www.genome.jp/kegg-bin/show_pathway?ko00360 KEGG_Reaction rn:R09840 http://www.genome.jp/dbget-bin/www_bget?rn:R09840 OMA GHGIAHG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GHGIAHG PDB 1PSU http://www.ebi.ac.uk/pdbe-srv/view/entry/1PSU PDB 2FS2 http://www.ebi.ac.uk/pdbe-srv/view/entry/2FS2 PDBsum 1PSU http://www.ebi.ac.uk/pdbsum/1PSU PDBsum 2FS2 http://www.ebi.ac.uk/pdbsum/2FS2 PSORT swissprot:PAAI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PAAI_ECOLI PSORT-B swissprot:PAAI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PAAI_ECOLI PSORT2 swissprot:PAAI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PAAI_ECOLI Pfam PF03061 http://pfam.xfam.org/family/PF03061 Phobius swissprot:PAAI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PAAI_ECOLI PhylomeDB P76084 http://phylomedb.org/?seqid=P76084 ProteinModelPortal P76084 http://www.proteinmodelportal.org/query/uniprot/P76084 PubMed 10766858 http://www.ncbi.nlm.nih.gov/pubmed/10766858 PubMed 16464851 http://www.ncbi.nlm.nih.gov/pubmed/16464851 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9748275 http://www.ncbi.nlm.nih.gov/pubmed/9748275 RefSeq NP_415914 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415914 RefSeq WP_000018413 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000018413 SMR P76084 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76084 STRING 511145.b1396 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1396&targetmode=cogs STRING COG2050 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2050&targetmode=cogs SUPFAM SSF54637 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54637 TIGRFAMs TIGR00369 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00369 TIGRFAMs TIGR02286 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02286 UniProtKB PAAI_ECOLI http://www.uniprot.org/uniprot/PAAI_ECOLI UniProtKB-AC P76084 http://www.uniprot.org/uniprot/P76084 charge swissprot:PAAI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PAAI_ECOLI eggNOG COG2050 http://eggnogapi.embl.de/nog_data/html/tree/COG2050 eggNOG ENOG4108ZJI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZJI epestfind swissprot:PAAI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PAAI_ECOLI garnier swissprot:PAAI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PAAI_ECOLI helixturnhelix swissprot:PAAI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PAAI_ECOLI hmoment swissprot:PAAI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PAAI_ECOLI iep swissprot:PAAI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PAAI_ECOLI inforesidue swissprot:PAAI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PAAI_ECOLI octanol swissprot:PAAI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PAAI_ECOLI pepcoil swissprot:PAAI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PAAI_ECOLI pepdigest swissprot:PAAI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PAAI_ECOLI pepinfo swissprot:PAAI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PAAI_ECOLI pepnet swissprot:PAAI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PAAI_ECOLI pepstats swissprot:PAAI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PAAI_ECOLI pepwheel swissprot:PAAI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PAAI_ECOLI pepwindow swissprot:PAAI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PAAI_ECOLI sigcleave swissprot:PAAI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PAAI_ECOLI ## Database ID URL or Descriptions # BioGrid 4260003 347 # DOMAIN MACA_ECOLI The periplasmic domain is sufficient to bind MacB. The membrane proximal (MP) region plays a critical role in the stimulation of MacB ATPase activity. {ECO 0000269|PubMed 17214741, ECO 0000269|PubMed 21696464}. # EcoGene EG13694 macA # FUNCTION MACA_ECOLI Part of the tripartite efflux system MacAB-TolC. MacA stimulates the ATPase activity of MacB by promoting the closed ATP-bound state of MacB, increases the capacity of MacB to bind macrolides such as erythromycin, and provides a physical link between MacB and TolC. When overexpressed, the system confers resistance against macrolides composed of 14- and 15-membered lactones but no or weak resistance against 16-membered ones. In addition, MacA binds tightly rough-core lipopolysaccharide (R- LPS), suggesting that the system could also transport R-LPS or a similar glycolipid. {ECO 0000269|PubMed 11544226, ECO 0000269|PubMed 17214741, ECO 0000269|PubMed 18955484, ECO 0000269|PubMed 21696464, ECO 0000269|PubMed 23974027}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_component GO:0019898 extrinsic component of membrane; IDA:EcoliWiki. # GO_function GO:0022891 substrate-specific transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0046618 drug export; IMP:EcoCyc. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # INDUCTION Expressed at very low levels under standard laboratory conditions. {ECO:0000269|PubMed 17214741}. # INTERACTION MACA_ECOLI Self; NbExp=2; IntAct=EBI-551961, EBI-551961; P75831 macB; NbExp=2; IntAct=EBI-551961, EBI-1125580; # IntAct P75830 9 # InterPro IPR006143 RND_pump_MFP # InterPro IPR030190 MacA # InterPro IPR032317 HlyD_D23 # Organism MACA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30572:SF10 PTHR30572:SF10 # PATRIC 32116965 VBIEscCol129921_0908 # PDB 3FPP X-ray; 2.99 A; A/B=31-371 # PIR F64826 F64826 # Pfam PF16576 HlyD_D23 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MACA_ECOLI Macrolide export protein MacA # RefSeq NP_415399 NC_000913.3 # RefSeq WP_000746442 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAB64541.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. {ECO 0000305}. # SUBCELLULAR LOCATION MACA_ECOLI Cell inner membrane {ECO 0000269|PubMed 11544226, ECO 0000269|PubMed 17214741}; Single-pass membrane protein {ECO 0000269|PubMed 11544226, ECO 0000269|PubMed 17214741}; Periplasmic side {ECO 0000269|PubMed 11544226, ECO 0000269|PubMed 17214741}. # SUBUNIT MACA_ECOLI Homohexamer. Part of the tripartite efflux system MacAB- TolC, which is composed of an inner membrane transporter, MacB, a periplasmic membrane fusion protein, MacA, and an outer membrane component, TolC. The complex forms a large protein conduit and can translocate molecules across both the inner and outer membranes. MacA interacts with MacB and TolC, and this interaction changes its conformation. {ECO 0000269|PubMed 17214741, ECO 0000269|PubMed 18955484, ECO 0000269|PubMed 19254725, ECO 0000269|PubMed 21325274, ECO 0000269|PubMed 21696464}. # TCDB 3.A.1.122 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR01730 RND_mfp # eggNOG COG0845 LUCA # eggNOG ENOG4105DJY Bacteria BLAST swissprot:MACA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MACA_ECOLI BioCyc ECOL316407:JW0862-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0862-MONOMER BioCyc EcoCyc:MACA http://biocyc.org/getid?id=EcoCyc:MACA COG COG0845 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0845 DIP DIP-11460N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11460N DOI 10.1016/j.jmb.2009.02.048 http://dx.doi.org/10.1016/j.jmb.2009.02.048 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M110.202598 http://dx.doi.org/10.1074/jbc.M110.202598 DOI 10.1074/jbc.M806964200 http://dx.doi.org/10.1074/jbc.M806964200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.2006.05549.x http://dx.doi.org/10.1111/j.1365-2958.2006.05549.x DOI 10.1111/j.1365-2958.2011.07744.x http://dx.doi.org/10.1111/j.1365-2958.2011.07744.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00756-13 http://dx.doi.org/10.1128/JB.00756-13 DOI 10.1128/JB.183.19.5639-5644.2001 http://dx.doi.org/10.1128/JB.183.19.5639-5644.2001 EMBL AB071145 http://www.ebi.ac.uk/ena/data/view/AB071145 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3458 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3458 EcoGene EG13694 http://www.ecogene.org/geneInfo.php?eg_id=EG13694 EnsemblBacteria AAC73965 http://www.ensemblgenomes.org/id/AAC73965 EnsemblBacteria AAC73965 http://www.ensemblgenomes.org/id/AAC73965 EnsemblBacteria BAA35597 http://www.ensemblgenomes.org/id/BAA35597 EnsemblBacteria BAA35597 http://www.ensemblgenomes.org/id/BAA35597 EnsemblBacteria BAA35597 http://www.ensemblgenomes.org/id/BAA35597 EnsemblBacteria b0878 http://www.ensemblgenomes.org/id/b0878 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0019898 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019898 GO_function GO:0022891 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022891 GO_process GO:0046618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046618 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 947322 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947322 HOGENOM HOG000216993 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000216993&db=HOGENOM6 InParanoid P75830 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75830 IntAct P75830 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75830* InterPro IPR006143 http://www.ebi.ac.uk/interpro/entry/IPR006143 InterPro IPR030190 http://www.ebi.ac.uk/interpro/entry/IPR030190 InterPro IPR032317 http://www.ebi.ac.uk/interpro/entry/IPR032317 KEGG_Gene ecj:JW0862 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0862 KEGG_Gene eco:b0878 http://www.genome.jp/dbget-bin/www_bget?eco:b0878 KEGG_Orthology KO:K13888 http://www.genome.jp/dbget-bin/www_bget?KO:K13888 OMA RINPAIN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RINPAIN PANTHER PTHR30572:SF10 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30572:SF10 PDB 3FPP http://www.ebi.ac.uk/pdbe-srv/view/entry/3FPP PDBsum 3FPP http://www.ebi.ac.uk/pdbsum/3FPP PSORT swissprot:MACA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MACA_ECOLI PSORT-B swissprot:MACA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MACA_ECOLI PSORT2 swissprot:MACA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MACA_ECOLI Pfam PF16576 http://pfam.xfam.org/family/PF16576 Phobius swissprot:MACA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MACA_ECOLI PhylomeDB P75830 http://phylomedb.org/?seqid=P75830 ProteinModelPortal P75830 http://www.proteinmodelportal.org/query/uniprot/P75830 PubMed 11544226 http://www.ncbi.nlm.nih.gov/pubmed/11544226 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17214741 http://www.ncbi.nlm.nih.gov/pubmed/17214741 PubMed 18955484 http://www.ncbi.nlm.nih.gov/pubmed/18955484 PubMed 19254725 http://www.ncbi.nlm.nih.gov/pubmed/19254725 PubMed 21325274 http://www.ncbi.nlm.nih.gov/pubmed/21325274 PubMed 21696464 http://www.ncbi.nlm.nih.gov/pubmed/21696464 PubMed 23974027 http://www.ncbi.nlm.nih.gov/pubmed/23974027 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415399 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415399 RefSeq WP_000746442 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000746442 SMR P75830 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75830 STRING 511145.b0878 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0878&targetmode=cogs STRING COG0845 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0845&targetmode=cogs TCDB 3.A.1.122 http://www.tcdb.org/search/result.php?tc=3.A.1.122 TIGRFAMs TIGR01730 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01730 UniProtKB MACA_ECOLI http://www.uniprot.org/uniprot/MACA_ECOLI UniProtKB-AC P75830 http://www.uniprot.org/uniprot/P75830 charge swissprot:MACA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MACA_ECOLI eggNOG COG0845 http://eggnogapi.embl.de/nog_data/html/tree/COG0845 eggNOG ENOG4105DJY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DJY epestfind swissprot:MACA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MACA_ECOLI garnier swissprot:MACA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MACA_ECOLI helixturnhelix swissprot:MACA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MACA_ECOLI hmoment swissprot:MACA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MACA_ECOLI iep swissprot:MACA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MACA_ECOLI inforesidue swissprot:MACA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MACA_ECOLI octanol swissprot:MACA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MACA_ECOLI pepcoil swissprot:MACA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MACA_ECOLI pepdigest swissprot:MACA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MACA_ECOLI pepinfo swissprot:MACA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MACA_ECOLI pepnet swissprot:MACA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MACA_ECOLI pepstats swissprot:MACA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MACA_ECOLI pepwheel swissprot:MACA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MACA_ECOLI pepwindow swissprot:MACA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MACA_ECOLI sigcleave swissprot:MACA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MACA_ECOLI ## Database ID URL or Descriptions # AltName INSB5_ECOLI IS1h # CAUTION There is no equivalent of this gene in strain K12 / W3110. {ECO 0000305}. # EcoGene EG40002 insB5 # FUNCTION INSB5_ECOLI Absolutely required for transposition of IS1. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # InterPro IPR005063 Transposase_27 # Organism INSB5_ECOLI Escherichia coli (strain K12) # Pfam PF03400 DDE_Tnp_IS1 # Proteomes UP000000625 Chromosome # RecName INSB5_ECOLI Insertion element IS1 5 protein InsB # RefSeq NP_414562 NC_000913.3 # RefSeq NP_416407 NC_000913.3 # RefSeq NP_417902 NC_000913.3 # RefSeq WP_001119362 NZ_LN832404.1 # SIMILARITY Belongs to the transposase 27 family. {ECO 0000305}. # eggNOG COG1662 LUCA BLAST swissprot:INSB5_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSB5_ECOLI COG COG1662 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1662 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4756 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4756 EcoGene EG40002 http://www.ecogene.org/geneInfo.php?eg_id=EG40002 EnsemblBacteria AAC74963 http://www.ensemblgenomes.org/id/AAC74963 EnsemblBacteria AAC74963 http://www.ensemblgenomes.org/id/AAC74963 EnsemblBacteria b1893 http://www.ensemblgenomes.org/id/b1893 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GeneID 24944608 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24944608 GeneID 944743 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944743 GeneID 945867 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945867 GeneID 947949 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947949 HOGENOM HOG000036821 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000036821&db=HOGENOM6 InParanoid P0CF28 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CF28 InterPro IPR005063 http://www.ebi.ac.uk/interpro/entry/IPR005063 KEGG_Gene eco:b0021 http://www.genome.jp/dbget-bin/www_bget?eco:b0021 KEGG_Gene eco:b1893 http://www.genome.jp/dbget-bin/www_bget?eco:b1893 KEGG_Gene eco:b3445 http://www.genome.jp/dbget-bin/www_bget?eco:b3445 KEGG_Orthology KO:K07480 http://www.genome.jp/dbget-bin/www_bget?KO:K07480 PSORT swissprot:INSB5_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSB5_ECOLI PSORT-B swissprot:INSB5_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSB5_ECOLI PSORT2 swissprot:INSB5_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSB5_ECOLI Pfam PF03400 http://pfam.xfam.org/family/PF03400 Phobius swissprot:INSB5_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSB5_ECOLI PhylomeDB P0CF28 http://phylomedb.org/?seqid=P0CF28 ProteinModelPortal P0CF28 http://www.proteinmodelportal.org/query/uniprot/P0CF28 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414562 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414562 RefSeq NP_416407 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416407 RefSeq NP_417902 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417902 RefSeq WP_001119362 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001119362 STRING 511145.b3445 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3445&targetmode=cogs STRING COG1662 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1662&targetmode=cogs UniProtKB INSB5_ECOLI http://www.uniprot.org/uniprot/INSB5_ECOLI UniProtKB-AC P0CF28 http://www.uniprot.org/uniprot/P0CF28 charge swissprot:INSB5_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSB5_ECOLI eggNOG COG1662 http://eggnogapi.embl.de/nog_data/html/tree/COG1662 epestfind swissprot:INSB5_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSB5_ECOLI garnier swissprot:INSB5_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSB5_ECOLI helixturnhelix swissprot:INSB5_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSB5_ECOLI hmoment swissprot:INSB5_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSB5_ECOLI iep swissprot:INSB5_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSB5_ECOLI inforesidue swissprot:INSB5_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSB5_ECOLI octanol swissprot:INSB5_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSB5_ECOLI pepcoil swissprot:INSB5_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSB5_ECOLI pepdigest swissprot:INSB5_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSB5_ECOLI pepinfo swissprot:INSB5_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSB5_ECOLI pepnet swissprot:INSB5_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSB5_ECOLI pepstats swissprot:INSB5_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSB5_ECOLI pepwheel swissprot:INSB5_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSB5_ECOLI pepwindow swissprot:INSB5_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSB5_ECOLI sigcleave swissprot:INSB5_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSB5_ECOLI ## Database ID URL or Descriptions # AltName DADA_ECOLI D-alanine dehydrogenase # BIOPHYSICOCHEMICAL PROPERTIES DADA_ECOLI Kinetic parameters KM=30 mM for D-alanine {ECO 0000269|PubMed 13292, ECO 0000269|PubMed 15358424}; KM=6.4 mM for 3,4-dehydro-D-proline {ECO 0000269|PubMed 13292, ECO 0000269|PubMed 15358424}; pH dependence Optimum pH is about 8.9 with D-alanine as substrate and about 9 with 3,4-dehydro-D-proline as substrate. {ECO 0000269|PubMed 13292, ECO 0000269|PubMed 15358424}; # BioGrid 4260104 11 # CATALYTIC ACTIVITY DADA_ECOLI A D-amino acid + H(2)O + acceptor = a 2-oxo acid + NH(3) + reduced acceptor. {ECO 0000269|PubMed 13292, ECO 0000269|PubMed 15358424}. # CAUTION Was originally thought to be a heterodimer based on the purification of the enzyme first reported from E.coli B, but results of enzyme assays in PubMed:21378189 have indicated that DadA is solely responsible for the observed dehydrogenase activity. {ECO 0000305}. # COFACTOR Name=FAD; Xref=ChEBI:CHEBI 57692; Evidence={ECO:0000250}; # DISRUPTION PHENOTYPE Loss of the ability to utilize both D- and L-stereoisomers of alanine as sole sources of carbon, nitrogen and energy for growth. {ECO:0000269|PubMed 13292}. # ENZYME REGULATION DADA_ECOLI Is activated by the HinT protein. Is inhibited by D-cycloserine. {ECO 0000269|PubMed 15358424, ECO 0000269|PubMed 21754980}. # EcoGene EG11407 dadA # FUNCTION DADA_ECOLI Catalyzes the oxidative deamination of D-amino acids. Has broad substrate specificity; is mostly active on D-alanine, and to a lesser extent, on several other D-amino acids such as D- methionine, D-serine and D-proline, but not on L-alanine. Participates in the utilization of L-alanine and D-alanine as the sole source of carbon, nitrogen and energy for growth. Is also able to oxidize D-amino acid analogs such as 3,4-dehydro-D- proline, D-2-aminobutyrate, D-norvaline, D-norleucine, cis-4- hydroxy-D-proline, and DL-ethionine. {ECO 0000269|PubMed 13292, ECO 0000269|PubMed 15358424}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_function GO:0008718 D-amino-acid dehydrogenase activity; IDA:EcoCyc. # GO_process GO:0019478 D-amino acid catabolic process; IEA:UniProtKB-HAMAP. # GO_process GO:0019480 L-alanine oxidation to pyruvate via D-alanine; IMP:EcoCyc. # GO_process GO:0055130 D-alanine catabolic process; IMP:EcoCyc. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # Gene3D 3.40.50.720 -; 3. # HAMAP MF_01202 DadA # INDUCTION By D-alanine. Is regulated by catabolite repression. {ECO:0000269|PubMed 13292}. # IntAct P0A6J5 21 # InterPro IPR006076 FAD-dep_OxRdtase # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR023080 DadA # InterPro IPR023753 FAD/NAD-binding_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00360 Phenylalanine metabolism # Organism DADA_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid degradation; D-alanine degradation; NH(3) and pyruvate from D-alanine step 1/1. # PATRIC 32117624 VBIEscCol129921_1234 # PIR B53383 B53383 # Pfam PF01266 DAO # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DADA_ECOLI D-amino acid dehydrogenase # RefSeq NP_415707 NC_000913.3 # RefSeq WP_001266908 NZ_LN832404.1 # SIMILARITY Belongs to the DadA oxidoreductase family. {ECO 0000305}. # SUBCELLULAR LOCATION DADA_ECOLI Cell inner membrane {ECO 0000269|PubMed 13292, ECO 0000269|PubMed 15358424}; Peripheral membrane protein {ECO 0000269|PubMed 13292, ECO 0000269|PubMed 15358424}. # SUPFAM SSF51905 SSF51905; 3 # UniPathway UPA00043 UER00498 # eggNOG COG0665 LUCA # eggNOG ENOG4105MWK Bacteria BLAST swissprot:DADA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DADA_ECOLI BioCyc ECOL316407:JW1178-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1178-MONOMER BioCyc EcoCyc:DALADEHYDROGA-MONOMER http://biocyc.org/getid?id=EcoCyc:DALADEHYDROGA-MONOMER BioCyc MetaCyc:DALADEHYDROGA-MONOMER http://biocyc.org/getid?id=MetaCyc:DALADEHYDROGA-MONOMER COG COG0665 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0665 DIP DIP-6852N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-6852N DOI 10.1007/BF00332894 http://dx.doi.org/10.1007/BF00332894 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1574-6968.2004.tb09780.x http://dx.doi.org/10.1111/j.1574-6968.2004.tb09780.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pone.0020897 http://dx.doi.org/10.1371/journal.pone.0020897 EC_number EC:1.4.99.- {ECO:0000269|PubMed:13292, ECO:0000269|PubMed:15358424} http://www.genome.jp/dbget-bin/www_bget?EC:1.4.99.- {ECO:0000269|PubMed:13292, ECO:0000269|PubMed:15358424} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L02948 http://www.ebi.ac.uk/ena/data/view/L02948 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.4.99.- {ECO:0000269|PubMed:13292, ECO:0000269|PubMed:15358424} http://enzyme.expasy.org/EC/1.4.99.- {ECO:0000269|PubMed:13292, ECO:0000269|PubMed:15358424} EchoBASE EB1379 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1379 EcoGene EG11407 http://www.ecogene.org/geneInfo.php?eg_id=EG11407 EnsemblBacteria AAC74273 http://www.ensemblgenomes.org/id/AAC74273 EnsemblBacteria AAC74273 http://www.ensemblgenomes.org/id/AAC74273 EnsemblBacteria BAA36044 http://www.ensemblgenomes.org/id/BAA36044 EnsemblBacteria BAA36044 http://www.ensemblgenomes.org/id/BAA36044 EnsemblBacteria BAA36044 http://www.ensemblgenomes.org/id/BAA36044 EnsemblBacteria b1189 http://www.ensemblgenomes.org/id/b1189 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0008718 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008718 GO_process GO:0019478 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019478 GO_process GO:0019480 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019480 GO_process GO:0055130 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055130 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 945752 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945752 HAMAP MF_01202 http://hamap.expasy.org/unirule/MF_01202 HOGENOM HOG000217450 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000217450&db=HOGENOM6 InParanoid P0A6J5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6J5 IntAct P0A6J5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6J5* IntEnz 1.4.99.- {ECO:0000269|PubMed:13292, ECO:0000269|PubMed:15358424} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.4.99.- {ECO:0000269|PubMed:13292, ECO:0000269|PubMed:15358424} InterPro IPR006076 http://www.ebi.ac.uk/interpro/entry/IPR006076 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR023080 http://www.ebi.ac.uk/interpro/entry/IPR023080 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1178 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1178 KEGG_Gene eco:b1189 http://www.genome.jp/dbget-bin/www_bget?eco:b1189 KEGG_Orthology KO:K00285 http://www.genome.jp/dbget-bin/www_bget?KO:K00285 KEGG_Pathway ko00360 http://www.genome.jp/kegg-bin/show_pathway?ko00360 KEGG_Reaction rn:R01342 http://www.genome.jp/dbget-bin/www_bget?rn:R01342 KEGG_Reaction rn:R01374 http://www.genome.jp/dbget-bin/www_bget?rn:R01374 OMA CDNSGAY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CDNSGAY PSORT swissprot:DADA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DADA_ECOLI PSORT-B swissprot:DADA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DADA_ECOLI PSORT2 swissprot:DADA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DADA_ECOLI Pfam PF01266 http://pfam.xfam.org/family/PF01266 Phobius swissprot:DADA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DADA_ECOLI PhylomeDB P0A6J5 http://phylomedb.org/?seqid=P0A6J5 ProteinModelPortal P0A6J5 http://www.proteinmodelportal.org/query/uniprot/P0A6J5 PubMed 13292 http://www.ncbi.nlm.nih.gov/pubmed/13292 PubMed 15358424 http://www.ncbi.nlm.nih.gov/pubmed/15358424 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21754980 http://www.ncbi.nlm.nih.gov/pubmed/21754980 PubMed 7906689 http://www.ncbi.nlm.nih.gov/pubmed/7906689 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415707 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415707 RefSeq WP_001266908 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001266908 STRING 511145.b1189 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1189&targetmode=cogs STRING COG0665 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0665&targetmode=cogs SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 UniProtKB DADA_ECOLI http://www.uniprot.org/uniprot/DADA_ECOLI UniProtKB-AC P0A6J5 http://www.uniprot.org/uniprot/P0A6J5 charge swissprot:DADA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DADA_ECOLI eggNOG COG0665 http://eggnogapi.embl.de/nog_data/html/tree/COG0665 eggNOG ENOG4105MWK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105MWK epestfind swissprot:DADA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DADA_ECOLI garnier swissprot:DADA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DADA_ECOLI helixturnhelix swissprot:DADA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DADA_ECOLI hmoment swissprot:DADA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DADA_ECOLI iep swissprot:DADA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DADA_ECOLI inforesidue swissprot:DADA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DADA_ECOLI octanol swissprot:DADA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DADA_ECOLI pepcoil swissprot:DADA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DADA_ECOLI pepdigest swissprot:DADA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DADA_ECOLI pepinfo swissprot:DADA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DADA_ECOLI pepnet swissprot:DADA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DADA_ECOLI pepstats swissprot:DADA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DADA_ECOLI pepwheel swissprot:DADA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DADA_ECOLI pepwindow swissprot:DADA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DADA_ECOLI sigcleave swissprot:DADA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DADA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262701 382 # CATALYTIC ACTIVITY FRDB_ECOLI Succinate + a quinone = fumarate + a quinol. # CDD cd00207 fer2 # COFACTOR Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI 49601; Note=Binds 1 [2Fe-2S] cluster.; # COFACTOR Name=[3Fe-4S] cluster; Xref=ChEBI:CHEBI 21137; Note=Binds 1 [3Fe-4S] cluster.; # COFACTOR Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI 49883; Note=Binds 1 [4Fe-4S] cluster.; # EcoGene EG10331 frdB # FUNCTION FRDB_ECOLI Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_component GO:0045284 plasma membrane fumarate reductase complex; IDA:EcoCyc. # GO_function GO:0000104 succinate dehydrogenase activity; IDA:EcoCyc. # GO_function GO:0008177 succinate dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC. # GO_function GO:0009055 electron carrier activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051536 iron-sulfur cluster binding; ISM:EcoCyc. # GO_function GO:0051537 2 iron, 2 sulfur cluster binding; IDA:EcoCyc. # GO_function GO:0051538 3 iron, 4 sulfur cluster binding; IDA:EcoCyc. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IDA:EcoCyc. # GO_process GO:0006099 tricarboxylic acid cycle; IEA:UniProtKB-KW. # GO_process GO:0006113 fermentation; IMP:EcoCyc. # GO_process GO:0009061 anaerobic respiration; IMP:EcoCyc. # GO_process GO:0044780 bacterial-type flagellum assembly; IMP:EcoCyc. # GO_process GO:0071973 bacterial-type flagellum-dependent cell motility; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0048870 cell motility # Gene3D 3.10.20.30 -; 1. # INTERACTION FRDB_ECOLI P00363 frdA; NbExp=4; IntAct=EBI-906724, EBI-550480; P08337 mutT; NbExp=4; IntAct=EBI-906724, EBI-1121389; P0A915 ompW; NbExp=2; IntAct=EBI-906724, EBI-1132929; # IntAct P0AC47 7 # InterPro IPR001041 2Fe-2S_ferredoxin-type # InterPro IPR004489 Succ_DH/fum_Rdtase_Fe-S # InterPro IPR006058 2Fe2S_fd_BS # InterPro IPR009051 Helical_ferredxn # InterPro IPR012675 Beta-grasp_dom # InterPro IPR017896 4Fe4S_Fe-S-bd # InterPro IPR017900 4Fe4S_Fe_S_CS # InterPro IPR025192 Succ_DH/fum_Rdtase_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00020 Citrate cycle (TCA cycle) # KEGG_Pathway ko00190 Oxidative phosphorylation # KEGG_Pathway ko00623 Toluene degradation # KEGG_Pathway ko00650 Butanoate metabolism # KEGG_Pathway ko00720 Carbon fixation pathways in prokaryotes # KEGG_Pathway ko02020 Two-component system # Organism FRDB_ECOLI Escherichia coli (strain K12) # PATRIC 32123879 VBIEscCol129921_4287 # PDB 1KF6 X-ray; 2.70 A; B/N=2-244 # PDB 1KFY X-ray; 3.60 A; B/N=2-244 # PDB 1L0V X-ray; 3.30 A; B/N=2-244 # PDB 2B76 X-ray; 3.30 A; B/N=2-244 # PDB 3CIR X-ray; 3.65 A; B/N=2-244 # PDB 3P4P X-ray; 2.80 A; B/N=2-244 # PDB 3P4Q X-ray; 3.35 A; B/N=2-244 # PDB 3P4R X-ray; 3.05 A; B/N=2-244 # PDB 3P4S X-ray; 3.10 A; B/N=2-244 # PIR A00377 RDECFS # PROSITE PS00197 2FE2S_FER_1 # PROSITE PS00198 4FE4S_FER_1 # PROSITE PS51085 2FE2S_FER_2 # PROSITE PS51379 4FE4S_FER_2 # Pfam PF13085 Fer2_3 # Pfam PF13183 Fer4_8 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FRDB_ECOLI Fumarate reductase iron-sulfur subunit # RefSeq NP_418577 NC_000913.3 # RefSeq WP_000829498 NZ_LN832404.1 # SIMILARITY Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. {ECO 0000305}. # SIMILARITY Contains 1 2Fe-2S ferredoxin-type domain. {ECO:0000255|PROSITE-ProRule PRU00465}. # SIMILARITY Contains 1 4Fe-4S ferredoxin-type domain. {ECO:0000255|PROSITE-ProRule PRU00711}. # SUBUNIT Fumarate dehydrogenase forms part of an enzyme complex containing four subunits a flavoprotein, an iron-sulfur, and two hydrophobic anchor proteins. # SUPFAM SSF46548 SSF46548 # SUPFAM SSF54292 SSF54292 # TIGRFAMs TIGR00384 dhsB # eggNOG COG0479 LUCA # eggNOG ENOG4105E33 Bacteria BLAST swissprot:FRDB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FRDB_ECOLI BioCyc ECOL316407:JW4114-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4114-MONOMER BioCyc EcoCyc:FUM-FE-S http://biocyc.org/getid?id=EcoCyc:FUM-FE-S BioCyc MetaCyc:FUM-FE-S http://biocyc.org/getid?id=MetaCyc:FUM-FE-S COG COG0479 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0479 DIP DIP-9682N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9682N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.79.4.1111 http://dx.doi.org/10.1073/pnas.79.4.1111 DOI 10.1073/pnas.87.22.8965 http://dx.doi.org/10.1073/pnas.87.22.8965 DOI 10.1074/jbc.M200815200 http://dx.doi.org/10.1074/jbc.M200815200 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1111/j.1432-1033.1982.tb06768.x http://dx.doi.org/10.1111/j.1432-1033.1982.tb06768.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1126/science.284.5422.1961 http://dx.doi.org/10.1126/science.284.5422.1961 EC_number EC:1.3.5.1 http://www.genome.jp/dbget-bin/www_bget?EC:1.3.5.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01611 http://www.ebi.ac.uk/ena/data/view/J01611 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL V00277 http://www.ebi.ac.uk/ena/data/view/V00277 ENZYME 1.3.5.1 http://enzyme.expasy.org/EC/1.3.5.1 EchoBASE EB0327 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0327 EcoGene EG10331 http://www.ecogene.org/geneInfo.php?eg_id=EG10331 EnsemblBacteria AAC77113 http://www.ensemblgenomes.org/id/AAC77113 EnsemblBacteria AAC77113 http://www.ensemblgenomes.org/id/AAC77113 EnsemblBacteria BAE78157 http://www.ensemblgenomes.org/id/BAE78157 EnsemblBacteria BAE78157 http://www.ensemblgenomes.org/id/BAE78157 EnsemblBacteria BAE78157 http://www.ensemblgenomes.org/id/BAE78157 EnsemblBacteria b4153 http://www.ensemblgenomes.org/id/b4153 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0045284 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045284 GO_function GO:0000104 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000104 GO_function GO:0008177 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008177 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051536 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051536 GO_function GO:0051537 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051537 GO_function GO:0051538 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051538 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0006099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006099 GO_process GO:0006113 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006113 GO_process GO:0009061 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009061 GO_process GO:0044780 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044780 GO_process GO:0071973 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071973 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 Gene3D 3.10.20.30 http://www.cathdb.info/version/latest/superfamily/3.10.20.30 GeneID 948666 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948666 HOGENOM HOG000160590 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000160590&db=HOGENOM6 InParanoid P0AC47 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AC47 IntAct P0AC47 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AC47* IntEnz 1.3.5.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.3.5.1 InterPro IPR001041 http://www.ebi.ac.uk/interpro/entry/IPR001041 InterPro IPR004489 http://www.ebi.ac.uk/interpro/entry/IPR004489 InterPro IPR006058 http://www.ebi.ac.uk/interpro/entry/IPR006058 InterPro IPR009051 http://www.ebi.ac.uk/interpro/entry/IPR009051 InterPro IPR012675 http://www.ebi.ac.uk/interpro/entry/IPR012675 InterPro IPR017896 http://www.ebi.ac.uk/interpro/entry/IPR017896 InterPro IPR017900 http://www.ebi.ac.uk/interpro/entry/IPR017900 InterPro IPR025192 http://www.ebi.ac.uk/interpro/entry/IPR025192 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4114 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4114 KEGG_Gene eco:b4153 http://www.genome.jp/dbget-bin/www_bget?eco:b4153 KEGG_Orthology KO:K00245 http://www.genome.jp/dbget-bin/www_bget?KO:K00245 KEGG_Pathway ko00020 http://www.genome.jp/kegg-bin/show_pathway?ko00020 KEGG_Pathway ko00190 http://www.genome.jp/kegg-bin/show_pathway?ko00190 KEGG_Pathway ko00623 http://www.genome.jp/kegg-bin/show_pathway?ko00623 KEGG_Pathway ko00650 http://www.genome.jp/kegg-bin/show_pathway?ko00650 KEGG_Pathway ko00720 http://www.genome.jp/kegg-bin/show_pathway?ko00720 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 KEGG_Reaction rn:R00408 http://www.genome.jp/dbget-bin/www_bget?rn:R00408 KEGG_Reaction rn:R00412 http://www.genome.jp/dbget-bin/www_bget?rn:R00412 OMA FKNFFGS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FKNFFGS PDB 1KF6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1KF6 PDB 1KFY http://www.ebi.ac.uk/pdbe-srv/view/entry/1KFY PDB 1L0V http://www.ebi.ac.uk/pdbe-srv/view/entry/1L0V PDB 2B76 http://www.ebi.ac.uk/pdbe-srv/view/entry/2B76 PDB 3CIR http://www.ebi.ac.uk/pdbe-srv/view/entry/3CIR PDB 3P4P http://www.ebi.ac.uk/pdbe-srv/view/entry/3P4P PDB 3P4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/3P4Q PDB 3P4R http://www.ebi.ac.uk/pdbe-srv/view/entry/3P4R PDB 3P4S http://www.ebi.ac.uk/pdbe-srv/view/entry/3P4S PDBsum 1KF6 http://www.ebi.ac.uk/pdbsum/1KF6 PDBsum 1KFY http://www.ebi.ac.uk/pdbsum/1KFY PDBsum 1L0V http://www.ebi.ac.uk/pdbsum/1L0V PDBsum 2B76 http://www.ebi.ac.uk/pdbsum/2B76 PDBsum 3CIR http://www.ebi.ac.uk/pdbsum/3CIR PDBsum 3P4P http://www.ebi.ac.uk/pdbsum/3P4P PDBsum 3P4Q http://www.ebi.ac.uk/pdbsum/3P4Q PDBsum 3P4R http://www.ebi.ac.uk/pdbsum/3P4R PDBsum 3P4S http://www.ebi.ac.uk/pdbsum/3P4S PROSITE PS00197 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00197 PROSITE PS00198 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00198 PROSITE PS51085 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51085 PROSITE PS51379 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51379 PSORT swissprot:FRDB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FRDB_ECOLI PSORT-B swissprot:FRDB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FRDB_ECOLI PSORT2 swissprot:FRDB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FRDB_ECOLI Pfam PF13085 http://pfam.xfam.org/family/PF13085 Pfam PF13183 http://pfam.xfam.org/family/PF13183 Phobius swissprot:FRDB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FRDB_ECOLI PhylomeDB P0AC47 http://phylomedb.org/?seqid=P0AC47 ProteinModelPortal P0AC47 http://www.proteinmodelportal.org/query/uniprot/P0AC47 PubMed 10373108 http://www.ncbi.nlm.nih.gov/pubmed/10373108 PubMed 11850430 http://www.ncbi.nlm.nih.gov/pubmed/11850430 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2174169 http://www.ncbi.nlm.nih.gov/pubmed/2174169 PubMed 6751816 http://www.ncbi.nlm.nih.gov/pubmed/6751816 PubMed 7041115 http://www.ncbi.nlm.nih.gov/pubmed/7041115 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_418577 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418577 RefSeq WP_000829498 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000829498 SMR P0AC47 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AC47 STRING 511145.b4153 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4153&targetmode=cogs STRING COG0479 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0479&targetmode=cogs SUPFAM SSF46548 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46548 SUPFAM SSF54292 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54292 TIGRFAMs TIGR00384 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00384 UniProtKB FRDB_ECOLI http://www.uniprot.org/uniprot/FRDB_ECOLI UniProtKB-AC P0AC47 http://www.uniprot.org/uniprot/P0AC47 charge swissprot:FRDB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FRDB_ECOLI eggNOG COG0479 http://eggnogapi.embl.de/nog_data/html/tree/COG0479 eggNOG ENOG4105E33 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E33 epestfind swissprot:FRDB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FRDB_ECOLI garnier swissprot:FRDB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FRDB_ECOLI helixturnhelix swissprot:FRDB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FRDB_ECOLI hmoment swissprot:FRDB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FRDB_ECOLI iep swissprot:FRDB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FRDB_ECOLI inforesidue swissprot:FRDB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FRDB_ECOLI octanol swissprot:FRDB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FRDB_ECOLI pepcoil swissprot:FRDB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FRDB_ECOLI pepdigest swissprot:FRDB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FRDB_ECOLI pepinfo swissprot:FRDB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FRDB_ECOLI pepnet swissprot:FRDB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FRDB_ECOLI pepstats swissprot:FRDB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FRDB_ECOLI pepwheel swissprot:FRDB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FRDB_ECOLI pepwindow swissprot:FRDB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FRDB_ECOLI sigcleave swissprot:FRDB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FRDB_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters KM=2.5 uM for acetaldehyde; KM=3.6 uM for chloroacetaldehyde; KM=5.8 uM for propionaldehyde; KM=56.8 uM for benzaldehyde; KM=900 uM for 4-hydroperoxycyclophosphamide; Vmax=2 umol/min/mg enzyme with acetaldehyde as substrate; Vmax=3.3 umol/min/mg enzyme with chloroacetaldehyde as substrate; Vmax=1 umol/min/mg enzyme with propionaldehyde as substrate; Vmax=0.6 umol/min/mg enzyme with benzaldehyde as substrate; Vmax=0.2 umol/min/mg enzyme with 4-hydroperoxycyclophosphamide; Note=the highest catalytic efficiency was observed with acetaldehyde.; # BioGrid 4262555 6 # COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI 18420; # ENZYME REGULATION ALDB_ECOLI Negatively regulated by fis. Positively regulated by RpoS and crp. Induced by ethanol. Expression is maximally induced during the transition from exponential phase to stationary phase. # EcoGene EG12292 aldB # FUNCTION ALDB_ECOLI Catalyzes the NADP-dependent oxidation of diverse aldehydes such as chloroacetaldehyde, acetaldehyde, propionaldehyde, benzaldehyde, mafosfamide, 4- hydroperoxycyclophosphamide. Its preferred substrates are acetaldehyde and chloroacetaldehyde. # GO_function GO:0004029 aldehyde dehydrogenase (NAD) activity; IDA:EcoliWiki. # GO_function GO:0016491 oxidoreductase activity; IDA:EcoliWiki. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0045471 response to ethanol; IDA:EcoliWiki. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # Gene3D 3.40.309.10 -; 1. # Gene3D 3.40.605.10 -; 1. # IntAct P37685 3 # InterPro IPR015590 Aldehyde_DH_dom # InterPro IPR016160 Ald_DH_CS_CYS # InterPro IPR016161 Ald_DH/histidinol_DH # InterPro IPR016162 Ald_DH_N # InterPro IPR016163 Ald_DH_C # InterPro IPR029510 Ald_DH_CS_GLU # KEGG_Brite ko01000 Enzymes # MASS SPECTROMETRY Mass=56352; Method=MALDI; Range=1-512; Evidence={ECO:0000269|PubMed 15659684}; # MISCELLANEOUS ALDB_ECOLI Does not use either glyceraldehyde or glycolaldehyde as substrates. # Organism ALDB_ECOLI Escherichia coli (strain K12) # PATRIC 32122654 VBIEscCol129921_3704 # PIR S47809 S47809 # PROSITE PS00070 ALDEHYDE_DEHYDR_CYS # PROSITE PS00687 ALDEHYDE_DEHYDR_GLU # Pfam PF00171 Aldedh # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ALDB_ECOLI Aldehyde dehydrogenase B # RefSeq NP_418045 NC_000913.3 # RefSeq WP_000183980 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18565.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the aldehyde dehydrogenase family. {ECO 0000305}. # SUBUNIT ALDB_ECOLI Homotetramer. # SUPFAM SSF53720 SSF53720 # eggNOG COG1012 LUCA # eggNOG ENOG4105C26 Bacteria BLAST swissprot:ALDB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ALDB_ECOLI BioCyc ECOL316407:JW3561-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3561-MONOMER BioCyc EcoCyc:ALDDEHYDROGB-MONOMER http://biocyc.org/getid?id=EcoCyc:ALDDEHYDROGB-MONOMER BioCyc MetaCyc:ALDDEHYDROGB-MONOMER http://biocyc.org/getid?id=MetaCyc:ALDDEHYDROGB-MONOMER COG COG1012 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1012 DIP DIP-9082N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9082N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.187.3.1067-1073.2005 http://dx.doi.org/10.1128/JB.187.3.1067-1073.2005 EC_number EC:1.2.1.- http://www.genome.jp/dbget-bin/www_bget?EC:1.2.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L40742 http://www.ebi.ac.uk/ena/data/view/L40742 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.2.1.- http://enzyme.expasy.org/EC/1.2.1.- EchoBASE EB2200 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2200 EcoGene EG12292 http://www.ecogene.org/geneInfo.php?eg_id=EG12292 EnsemblBacteria AAC76612 http://www.ensemblgenomes.org/id/AAC76612 EnsemblBacteria AAC76612 http://www.ensemblgenomes.org/id/AAC76612 EnsemblBacteria BAE77705 http://www.ensemblgenomes.org/id/BAE77705 EnsemblBacteria BAE77705 http://www.ensemblgenomes.org/id/BAE77705 EnsemblBacteria BAE77705 http://www.ensemblgenomes.org/id/BAE77705 EnsemblBacteria b3588 http://www.ensemblgenomes.org/id/b3588 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004029 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004029 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0045471 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045471 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.309.10 http://www.cathdb.info/version/latest/superfamily/3.40.309.10 Gene3D 3.40.605.10 http://www.cathdb.info/version/latest/superfamily/3.40.605.10 GeneID 948104 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948104 HOGENOM HOG000271505 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000271505&db=HOGENOM6 InParanoid P37685 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37685 IntAct P37685 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37685* IntEnz 1.2.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.2.1 InterPro IPR015590 http://www.ebi.ac.uk/interpro/entry/IPR015590 InterPro IPR016160 http://www.ebi.ac.uk/interpro/entry/IPR016160 InterPro IPR016161 http://www.ebi.ac.uk/interpro/entry/IPR016161 InterPro IPR016162 http://www.ebi.ac.uk/interpro/entry/IPR016162 InterPro IPR016163 http://www.ebi.ac.uk/interpro/entry/IPR016163 InterPro IPR029510 http://www.ebi.ac.uk/interpro/entry/IPR029510 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3561 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3561 KEGG_Gene eco:b3588 http://www.genome.jp/dbget-bin/www_bget?eco:b3588 KEGG_Orthology KO:K00138 http://www.genome.jp/dbget-bin/www_bget?KO:K00138 MINT MINT-7290779 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-7290779 OMA HLIMEAA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HLIMEAA PROSITE PS00070 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00070 PROSITE PS00687 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00687 PSORT swissprot:ALDB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ALDB_ECOLI PSORT-B swissprot:ALDB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ALDB_ECOLI PSORT2 swissprot:ALDB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ALDB_ECOLI Pfam PF00171 http://pfam.xfam.org/family/PF00171 Phobius swissprot:ALDB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ALDB_ECOLI PhylomeDB P37685 http://phylomedb.org/?seqid=P37685 ProteinModelPortal P37685 http://www.proteinmodelportal.org/query/uniprot/P37685 PubMed 15659684 http://www.ncbi.nlm.nih.gov/pubmed/15659684 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7768815 http://www.ncbi.nlm.nih.gov/pubmed/7768815 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418045 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418045 RefSeq WP_000183980 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000183980 SMR P37685 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37685 STRING 511145.b3588 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3588&targetmode=cogs STRING COG1012 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1012&targetmode=cogs SUPFAM SSF53720 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53720 UniProtKB ALDB_ECOLI http://www.uniprot.org/uniprot/ALDB_ECOLI UniProtKB-AC P37685 http://www.uniprot.org/uniprot/P37685 charge swissprot:ALDB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ALDB_ECOLI eggNOG COG1012 http://eggnogapi.embl.de/nog_data/html/tree/COG1012 eggNOG ENOG4105C26 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C26 epestfind swissprot:ALDB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ALDB_ECOLI garnier swissprot:ALDB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ALDB_ECOLI helixturnhelix swissprot:ALDB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ALDB_ECOLI hmoment swissprot:ALDB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ALDB_ECOLI iep swissprot:ALDB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ALDB_ECOLI inforesidue swissprot:ALDB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ALDB_ECOLI octanol swissprot:ALDB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ALDB_ECOLI pepcoil swissprot:ALDB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ALDB_ECOLI pepdigest swissprot:ALDB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ALDB_ECOLI pepinfo swissprot:ALDB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ALDB_ECOLI pepnet swissprot:ALDB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ALDB_ECOLI pepstats swissprot:ALDB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ALDB_ECOLI pepwheel swissprot:ALDB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ALDB_ECOLI pepwindow swissprot:ALDB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ALDB_ECOLI sigcleave swissprot:ALDB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ALDB_ECOLI ## Database ID URL or Descriptions # BioGrid 4263354 31 # DISRUPTION PHENOTYPE Deletion of the ratA-ratB operon has no effect on bacterial persistence on rich medium for this strain, but does affect bacterial persistence for E.coli strain CFT073. {ECO:0000269|PubMed 23055930}. # EcoGene EG13192 ratB # FUNCTION RATB_ECOLI Does not function as an antitoxin to the upstream RatA toxin. # Gene3D 3.10.20.280 -; 1. # HAMAP MF_00460 UPF0125_RnfH # IntAct P52119 19 # InterPro IPR005346 RnfH # InterPro IPR016155 Mopterin_synth/thiamin_S_b # Organism RATB_ECOLI Escherichia coli (strain K12) # PATRIC 32120635 VBIEscCol129921_2716 # PIR T08631 T08631 # Pfam PF03658 Ub-RnfH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RATB_ECOLI UPF0125 protein RatB # RefSeq NP_417108 NC_000913.3 # RefSeq WP_001117838 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA79788.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the UPF0125 (RnfH) family. {ECO 0000305}. # SUPFAM SSF54285 SSF54285 # eggNOG COG2914 LUCA # eggNOG ENOG4105VDB Bacteria BLAST swissprot:RATB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RATB_ECOLI BioCyc ECOL316407:JW2599-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2599-MONOMER BioCyc EcoCyc:G7357-MONOMER http://biocyc.org/getid?id=EcoCyc:G7357-MONOMER COG COG2914 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2914 DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.91.20.9223 http://dx.doi.org/10.1073/pnas.91.20.9223 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1365-2958.2010.07506.x http://dx.doi.org/10.1111/j.1365-2958.2010.07506.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.ppat.1002954 http://dx.doi.org/10.1371/journal.ppat.1002954 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D12501 http://www.ebi.ac.uk/ena/data/view/D12501 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36840 http://www.ebi.ac.uk/ena/data/view/U36840 EchoBASE EB2984 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2984 EcoGene EG13192 http://www.ecogene.org/geneInfo.php?eg_id=EG13192 EnsemblBacteria AAC75667 http://www.ensemblgenomes.org/id/AAC75667 EnsemblBacteria AAC75667 http://www.ensemblgenomes.org/id/AAC75667 EnsemblBacteria BAA16503 http://www.ensemblgenomes.org/id/BAA16503 EnsemblBacteria BAA16503 http://www.ensemblgenomes.org/id/BAA16503 EnsemblBacteria BAA16503 http://www.ensemblgenomes.org/id/BAA16503 EnsemblBacteria b2618 http://www.ensemblgenomes.org/id/b2618 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.10.20.280 http://www.cathdb.info/version/latest/superfamily/3.10.20.280 GeneID 945078 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945078 HAMAP MF_00460 http://hamap.expasy.org/unirule/MF_00460 HOGENOM HOG000261719 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261719&db=HOGENOM6 InParanoid P52119 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P52119 IntAct P52119 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P52119* InterPro IPR005346 http://www.ebi.ac.uk/interpro/entry/IPR005346 InterPro IPR016155 http://www.ebi.ac.uk/interpro/entry/IPR016155 KEGG_Gene ecj:JW2599 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2599 KEGG_Gene eco:b2618 http://www.genome.jp/dbget-bin/www_bget?eco:b2618 KEGG_Orthology KO:K09801 http://www.genome.jp/dbget-bin/www_bget?KO:K09801 OMA GRINKIT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GRINKIT PSORT swissprot:RATB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RATB_ECOLI PSORT-B swissprot:RATB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RATB_ECOLI PSORT2 swissprot:RATB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RATB_ECOLI Pfam PF03658 http://pfam.xfam.org/family/PF03658 Phobius swissprot:RATB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RATB_ECOLI PhylomeDB P52119 http://phylomedb.org/?seqid=P52119 ProteinModelPortal P52119 http://www.proteinmodelportal.org/query/uniprot/P52119 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21323758 http://www.ncbi.nlm.nih.gov/pubmed/21323758 PubMed 23055930 http://www.ncbi.nlm.nih.gov/pubmed/23055930 PubMed 7524073 http://www.ncbi.nlm.nih.gov/pubmed/7524073 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417108 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417108 RefSeq WP_001117838 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001117838 SMR P52119 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P52119 STRING 511145.b2618 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2618&targetmode=cogs STRING COG2914 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2914&targetmode=cogs SUPFAM SSF54285 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54285 UniProtKB RATB_ECOLI http://www.uniprot.org/uniprot/RATB_ECOLI UniProtKB-AC P52119 http://www.uniprot.org/uniprot/P52119 charge swissprot:RATB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RATB_ECOLI eggNOG COG2914 http://eggnogapi.embl.de/nog_data/html/tree/COG2914 eggNOG ENOG4105VDB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VDB epestfind swissprot:RATB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RATB_ECOLI garnier swissprot:RATB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RATB_ECOLI helixturnhelix swissprot:RATB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RATB_ECOLI hmoment swissprot:RATB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RATB_ECOLI iep swissprot:RATB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RATB_ECOLI inforesidue swissprot:RATB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RATB_ECOLI octanol swissprot:RATB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RATB_ECOLI pepcoil swissprot:RATB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RATB_ECOLI pepdigest swissprot:RATB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RATB_ECOLI pepinfo swissprot:RATB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RATB_ECOLI pepnet swissprot:RATB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RATB_ECOLI pepstats swissprot:RATB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RATB_ECOLI pepwheel swissprot:RATB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RATB_ECOLI pepwindow swissprot:RATB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RATB_ECOLI sigcleave swissprot:RATB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RATB_ECOLI ## Database ID URL or Descriptions # BioGrid 4263237 10 # EcoGene EG12532 yjgM # GO_function GO:0008080 N-acetyltransferase activity; IEA:InterPro. # GOslim_function GO:0016746 transferase activity, transferring acyl groups # Gene3D 3.40.630.30 -; 1. # InterPro IPR000182 GNAT_dom # InterPro IPR016181 Acyl_CoA_acyltransferase # KEGG_Brite ko01000 Enzymes # Organism YJGM_ECOLI Escherichia coli (strain K12) # PATRIC 32124083 VBIEscCol129921_4386 # PIR S56481 S56481 # PROSITE PS51186 GNAT # Pfam PF00583 Acetyltransf_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJGM_ECOLI Uncharacterized N-acetyltransferase YjgM # RefSeq WP_001059402 NZ_LN832404.1 # RefSeq YP_026287 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA97152.1; Type=Frameshift; Positions=11, 21; Evidence={ECO 0000305}; # SIMILARITY Belongs to the acetyltransferase family. {ECO 0000305}. # SIMILARITY Contains 1 N-acetyltransferase domain. {ECO:0000255|PROSITE-ProRule PRU00532}. # SUPFAM SSF55729 SSF55729 # eggNOG ENOG4108MJ3 Bacteria # eggNOG ENOG4110MQC LUCA BLAST swissprot:YJGM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJGM_ECOLI BioCyc ECOL316407:JW5758-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5758-MONOMER BioCyc EcoCyc:G7886-MONOMER http://biocyc.org/getid?id=EcoCyc:G7886-MONOMER COG COG0454 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0454 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 2.3.1.- http://enzyme.expasy.org/EC/2.3.1.- EchoBASE EB2422 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2422 EcoGene EG12532 http://www.ecogene.org/geneInfo.php?eg_id=EG12532 EnsemblBacteria AAT48245 http://www.ensemblgenomes.org/id/AAT48245 EnsemblBacteria AAT48245 http://www.ensemblgenomes.org/id/AAT48245 EnsemblBacteria BAE78253 http://www.ensemblgenomes.org/id/BAE78253 EnsemblBacteria BAE78253 http://www.ensemblgenomes.org/id/BAE78253 EnsemblBacteria BAE78253 http://www.ensemblgenomes.org/id/BAE78253 EnsemblBacteria b4256 http://www.ensemblgenomes.org/id/b4256 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008080 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008080 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 Gene3D 3.40.630.30 http://www.cathdb.info/version/latest/superfamily/3.40.630.30 GeneID 948772 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948772 HOGENOM HOG000078529 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000078529&db=HOGENOM6 InParanoid P39337 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39337 IntEnz 2.3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1 InterPro IPR000182 http://www.ebi.ac.uk/interpro/entry/IPR000182 InterPro IPR016181 http://www.ebi.ac.uk/interpro/entry/IPR016181 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5758 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5758 KEGG_Gene eco:b4256 http://www.genome.jp/dbget-bin/www_bget?eco:b4256 KEGG_Orthology KO:K03828 http://www.genome.jp/dbget-bin/www_bget?KO:K03828 OMA YLETMPY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YLETMPY PROSITE PS51186 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51186 PSORT swissprot:YJGM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJGM_ECOLI PSORT-B swissprot:YJGM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJGM_ECOLI PSORT2 swissprot:YJGM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJGM_ECOLI Pfam PF00583 http://pfam.xfam.org/family/PF00583 Phobius swissprot:YJGM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJGM_ECOLI PhylomeDB P39337 http://phylomedb.org/?seqid=P39337 ProteinModelPortal P39337 http://www.proteinmodelportal.org/query/uniprot/P39337 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001059402 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001059402 RefSeq YP_026287 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026287 SMR P39337 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39337 STRING 511145.b4256 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4256&targetmode=cogs STRING COG0454 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0454&targetmode=cogs SUPFAM SSF55729 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55729 UniProtKB YJGM_ECOLI http://www.uniprot.org/uniprot/YJGM_ECOLI UniProtKB-AC P39337 http://www.uniprot.org/uniprot/P39337 charge swissprot:YJGM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJGM_ECOLI eggNOG ENOG4108MJ3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MJ3 eggNOG ENOG4110MQC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4110MQC epestfind swissprot:YJGM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJGM_ECOLI garnier swissprot:YJGM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJGM_ECOLI helixturnhelix swissprot:YJGM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJGM_ECOLI hmoment swissprot:YJGM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJGM_ECOLI iep swissprot:YJGM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJGM_ECOLI inforesidue swissprot:YJGM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJGM_ECOLI octanol swissprot:YJGM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJGM_ECOLI pepcoil swissprot:YJGM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJGM_ECOLI pepdigest swissprot:YJGM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJGM_ECOLI pepinfo swissprot:YJGM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJGM_ECOLI pepnet swissprot:YJGM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJGM_ECOLI pepstats swissprot:YJGM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJGM_ECOLI pepwheel swissprot:YJGM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJGM_ECOLI pepwindow swissprot:YJGM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJGM_ECOLI sigcleave swissprot:YJGM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJGM_ECOLI ## Database ID URL or Descriptions # AltName AIS_ECOLI Polymyxin resistance protein PmrG # BioGrid 4260487 11 # EcoGene EG13155 ais # FUNCTION AIS_ECOLI Catalyzes the dephosphorylation of heptose(II) of the outer membrane lipopolysaccharide core. {ECO 0000250}. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_function GO:0016791 phosphatase activity; IEA:UniProtKB-HAMAP. # GO_process GO:0008653 lipopolysaccharide metabolic process; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016791 phosphatase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # Gene3D 3.40.50.1240 -; 1. # HAMAP MF_01868 Ais # INDUCTION Induced by BasR (By similarity). Expression is significantly induced in the presence of zinc. {ECO:0000250, ECO 0000269|PubMed:15659689}. # IntAct P45565 2 # InterPro IPR011310 LipoPS_heptP_Pase # InterPro IPR013078 His_Pase_superF_clade-1 # InterPro IPR029033 His_PPase_superfam # Organism AIS_ECOLI Escherichia coli (strain K12) # PATHWAY AIS_ECOLI Bacterial outer membrane biogenesis; lipopolysaccharide metabolism. # PATRIC 32119869 VBIEscCol129921_2344 # PIR B64996 B64996 # PIRSF PIRSF011416 Ais-TraG-AfrS # Pfam PF00300 His_Phos_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AIS_ECOLI Lipopolysaccharide core heptose(II)-phosphate phosphatase # RefSeq NP_416755 NC_000913.3 # RefSeq WP_000879112 NZ_LN832404.1 # SIMILARITY Belongs to the phosphoglycerate mutase family. Ais subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION AIS_ECOLI Periplasm {ECO 0000250}. # SUPFAM SSF53254 SSF53254 # eggNOG ENOG4108WMR Bacteria # eggNOG ENOG4111KYS LUCA BLAST swissprot:AIS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AIS_ECOLI BioCyc ECOL316407:JW2246-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2246-MONOMER BioCyc EcoCyc:G7165-MONOMER http://biocyc.org/getid?id=EcoCyc:G7165-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.187.3.1124-1134.2005 http://dx.doi.org/10.1128/JB.187.3.1124-1134.2005 EC_number EC:3.1.3.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X83874 http://www.ebi.ac.uk/ena/data/view/X83874 ENZYME 3.1.3.- http://enzyme.expasy.org/EC/3.1.3.- EchoBASE EB2949 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2949 EcoGene EG13155 http://www.ecogene.org/geneInfo.php?eg_id=EG13155 EnsemblBacteria AAC75312 http://www.ensemblgenomes.org/id/AAC75312 EnsemblBacteria AAC75312 http://www.ensemblgenomes.org/id/AAC75312 EnsemblBacteria BAA16075 http://www.ensemblgenomes.org/id/BAA16075 EnsemblBacteria BAA16075 http://www.ensemblgenomes.org/id/BAA16075 EnsemblBacteria BAA16075 http://www.ensemblgenomes.org/id/BAA16075 EnsemblBacteria b2252 http://www.ensemblgenomes.org/id/b2252 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GO_process GO:0008653 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008653 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 Gene3D 3.40.50.1240 http://www.cathdb.info/version/latest/superfamily/3.40.50.1240 GeneID 944945 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944945 HAMAP MF_01868 http://hamap.expasy.org/unirule/MF_01868 HOGENOM HOG000122412 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122412&db=HOGENOM6 IntAct P45565 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45565* IntEnz 3.1.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3 InterPro IPR011310 http://www.ebi.ac.uk/interpro/entry/IPR011310 InterPro IPR013078 http://www.ebi.ac.uk/interpro/entry/IPR013078 InterPro IPR029033 http://www.ebi.ac.uk/interpro/entry/IPR029033 KEGG_Gene ecj:JW2246 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2246 KEGG_Gene eco:b2252 http://www.genome.jp/dbget-bin/www_bget?eco:b2252 OMA NFTVIVW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NFTVIVW PSORT swissprot:AIS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AIS_ECOLI PSORT-B swissprot:AIS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AIS_ECOLI PSORT2 swissprot:AIS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AIS_ECOLI Pfam PF00300 http://pfam.xfam.org/family/PF00300 Phobius swissprot:AIS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AIS_ECOLI ProteinModelPortal P45565 http://www.proteinmodelportal.org/query/uniprot/P45565 PubMed 15659689 http://www.ncbi.nlm.nih.gov/pubmed/15659689 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416755 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416755 RefSeq WP_000879112 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000879112 SMR P45565 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45565 STRING 511145.b2252 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2252&targetmode=cogs SUPFAM SSF53254 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53254 UniProtKB AIS_ECOLI http://www.uniprot.org/uniprot/AIS_ECOLI UniProtKB-AC P45565 http://www.uniprot.org/uniprot/P45565 charge swissprot:AIS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AIS_ECOLI eggNOG ENOG4108WMR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108WMR eggNOG ENOG4111KYS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111KYS epestfind swissprot:AIS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AIS_ECOLI garnier swissprot:AIS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AIS_ECOLI helixturnhelix swissprot:AIS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AIS_ECOLI hmoment swissprot:AIS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AIS_ECOLI iep swissprot:AIS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AIS_ECOLI inforesidue swissprot:AIS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AIS_ECOLI octanol swissprot:AIS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AIS_ECOLI pepcoil swissprot:AIS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AIS_ECOLI pepdigest swissprot:AIS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AIS_ECOLI pepinfo swissprot:AIS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AIS_ECOLI pepnet swissprot:AIS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AIS_ECOLI pepstats swissprot:AIS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AIS_ECOLI pepwheel swissprot:AIS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AIS_ECOLI pepwindow swissprot:AIS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AIS_ECOLI sigcleave swissprot:AIS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AIS_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES GLPQ_ECOLI Kinetic parameters KM=0.28 mM for glycerophosphocholine {ECO 0000269|PubMed 2829735}; KM=0.24 mM for glycerophosphoethanolamine {ECO 0000269|PubMed 2829735}; KM=0.35 mM for glycerophosphoglycerol {ECO 0000269|PubMed 2829735}; KM=0.59 mM for glycerophosphoserine {ECO 0000269|PubMed 2829735}; KM=1.0 mM for glycerophosphoinositol {ECO 0000269|PubMed 2829735}; pH dependence Optimum pH is 7.8. {ECO 0000269|PubMed 2829735}; # BRENDA 3.1.4.46 2026 # BioGrid 4260486 168 # CATALYTIC ACTIVITY A glycerophosphodiester + H(2)O = an alcohol + sn-glycerol 3-phosphate. {ECO:0000269|PubMed 2829735}. # COFACTOR GLPQ_ECOLI Name=Ca(2+); Xref=ChEBI CHEBI 29108; Evidence={ECO 0000269|PubMed 2829735}; Note=Binds 1 Ca(2+) ion per subunit. {ECO 0000269|PubMed 2829735}; # EcoGene EG10399 glpQ # FUNCTION GLPQ_ECOLI Glycerophosphoryl diester phosphodiesterase hydrolyzes deacylated phospholipids to G3P and the corresponding alcohols. # GO_component GO:0042597 periplasmic space; IDA:EcoCyc. # GO_function GO:0005509 calcium ion binding; IDA:EcoCyc. # GO_function GO:0008889 glycerophosphodiester phosphodiesterase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IDA:EcoCyc. # GO_process GO:0006071 glycerol metabolic process; IEA:UniProtKB-KW. # GO_process GO:0006629 lipid metabolic process; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.190 -; 1. # IntAct P09394 11 # InterPro IPR004129 GlyceroP-diester-Pdiesterase # InterPro IPR017946 PLC-like_Pdiesterase_TIM-brl # InterPro IPR030395 GP_PDE_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00564 Glycerophospholipid metabolism # MISCELLANEOUS There are 2 isozymes of glycerophosphoryl diester phosphodiesterase in E.coli a periplasmic isozyme (GlpQ) and a cytosolic isozyme (UgpQ). # Organism GLPQ_ECOLI Escherichia coli (strain K12) # PANTHER PTHR23344 PTHR23344 # PATRIC 32119837 VBIEscCol129921_2328 # PDB 1T8Q X-ray; 2.00 A; A/B/C/D=25-358 # PDB 1YDY X-ray; 1.70 A; A/B=1-356 # PIR S15945 S15945 # PROSITE PS51704 GP_PDE # Pfam PF03009 GDPD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLPQ_ECOLI Glycerophosphoryl diester phosphodiesterase # RefSeq NP_416742 NC_000913.3 # RefSeq WP_000779105 NZ_LN832404.1 # SIMILARITY Belongs to the glycerophosphoryl diester phosphodiesterase family. {ECO 0000305}. # SIMILARITY Contains 1 GP-PDE domain. {ECO 0000305}. # SUBCELLULAR LOCATION GLPQ_ECOLI Periplasm {ECO 0000269|PubMed 2829735}. # SUBUNIT GLPQ_ECOLI Homodimer. {ECO 0000269|PubMed 2829735, ECO 0000269|Ref.10, ECO 0000269|Ref.9}. # SUPFAM SSF51695 SSF51695 # eggNOG COG0584 LUCA # eggNOG ENOG4106MZZ Bacteria BLAST swissprot:GLPQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLPQ_ECOLI BioCyc ECOL316407:JW2233-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2233-MONOMER BioCyc EcoCyc:GLYCPDIESTER-PERI-MONOMER http://biocyc.org/getid?id=EcoCyc:GLYCPDIESTER-PERI-MONOMER BioCyc MetaCyc:GLYCPDIESTER-PERI-MONOMER http://biocyc.org/getid?id=MetaCyc:GLYCPDIESTER-PERI-MONOMER COG COG0584 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0584 DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1007/BF00273621 http://dx.doi.org/10.1007/BF00273621 DOI 10.1016/0003-9861(88)90484-5 http://dx.doi.org/10.1016/0003-9861(88)90484-5 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1365-2958.1987.tb01931.x http://dx.doi.org/10.1111/j.1365-2958.1987.tb01931.x DOI 10.1111/j.1365-2958.1996.tb02652.x http://dx.doi.org/10.1111/j.1365-2958.1996.tb02652.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.4.46 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.4.46 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X56907 http://www.ebi.ac.uk/ena/data/view/X56907 EMBL Y00536 http://www.ebi.ac.uk/ena/data/view/Y00536 ENZYME 3.1.4.46 http://enzyme.expasy.org/EC/3.1.4.46 EchoBASE EB0394 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0394 EcoGene EG10399 http://www.ecogene.org/geneInfo.php?eg_id=EG10399 EnsemblBacteria AAC75299 http://www.ensemblgenomes.org/id/AAC75299 EnsemblBacteria AAC75299 http://www.ensemblgenomes.org/id/AAC75299 EnsemblBacteria BAA16058 http://www.ensemblgenomes.org/id/BAA16058 EnsemblBacteria BAA16058 http://www.ensemblgenomes.org/id/BAA16058 EnsemblBacteria BAA16058 http://www.ensemblgenomes.org/id/BAA16058 EnsemblBacteria b2239 http://www.ensemblgenomes.org/id/b2239 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0005509 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509 GO_function GO:0008889 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008889 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006071 GO_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.190 http://www.cathdb.info/version/latest/superfamily/3.20.20.190 GeneID 946725 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946725 HOGENOM HOG000004696 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000004696&db=HOGENOM6 InParanoid P09394 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P09394 IntAct P09394 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P09394* IntEnz 3.1.4.46 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.4.46 InterPro IPR004129 http://www.ebi.ac.uk/interpro/entry/IPR004129 InterPro IPR017946 http://www.ebi.ac.uk/interpro/entry/IPR017946 InterPro IPR030395 http://www.ebi.ac.uk/interpro/entry/IPR030395 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2233 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2233 KEGG_Gene eco:b2239 http://www.genome.jp/dbget-bin/www_bget?eco:b2239 KEGG_Orthology KO:K01126 http://www.genome.jp/dbget-bin/www_bget?KO:K01126 KEGG_Pathway ko00564 http://www.genome.jp/kegg-bin/show_pathway?ko00564 KEGG_Reaction rn:R01030 http://www.genome.jp/dbget-bin/www_bget?rn:R01030 KEGG_Reaction rn:R01470 http://www.genome.jp/dbget-bin/www_bget?rn:R01470 OMA GRFYAID http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GRFYAID PANTHER PTHR23344 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23344 PDB 1T8Q http://www.ebi.ac.uk/pdbe-srv/view/entry/1T8Q PDB 1YDY http://www.ebi.ac.uk/pdbe-srv/view/entry/1YDY PDBsum 1T8Q http://www.ebi.ac.uk/pdbsum/1T8Q PDBsum 1YDY http://www.ebi.ac.uk/pdbsum/1YDY PROSITE PS51704 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51704 PSORT swissprot:GLPQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLPQ_ECOLI PSORT-B swissprot:GLPQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLPQ_ECOLI PSORT2 swissprot:GLPQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLPQ_ECOLI Pfam PF03009 http://pfam.xfam.org/family/PF03009 Phobius swissprot:GLPQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLPQ_ECOLI PhylomeDB P09394 http://phylomedb.org/?seqid=P09394 ProteinModelPortal P09394 http://www.proteinmodelportal.org/query/uniprot/P09394 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1851953 http://www.ncbi.nlm.nih.gov/pubmed/1851953 PubMed 2829735 http://www.ncbi.nlm.nih.gov/pubmed/2829735 PubMed 3329281 http://www.ncbi.nlm.nih.gov/pubmed/3329281 PubMed 8899705 http://www.ncbi.nlm.nih.gov/pubmed/8899705 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_416742 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416742 RefSeq WP_000779105 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000779105 SMR P09394 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P09394 STRING 511145.b2239 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2239&targetmode=cogs STRING COG0584 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0584&targetmode=cogs SUPFAM SSF51695 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51695 UniProtKB GLPQ_ECOLI http://www.uniprot.org/uniprot/GLPQ_ECOLI UniProtKB-AC P09394 http://www.uniprot.org/uniprot/P09394 charge swissprot:GLPQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLPQ_ECOLI eggNOG COG0584 http://eggnogapi.embl.de/nog_data/html/tree/COG0584 eggNOG ENOG4106MZZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106MZZ epestfind swissprot:GLPQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLPQ_ECOLI garnier swissprot:GLPQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLPQ_ECOLI helixturnhelix swissprot:GLPQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLPQ_ECOLI hmoment swissprot:GLPQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLPQ_ECOLI iep swissprot:GLPQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLPQ_ECOLI inforesidue swissprot:GLPQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLPQ_ECOLI octanol swissprot:GLPQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLPQ_ECOLI pepcoil swissprot:GLPQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLPQ_ECOLI pepdigest swissprot:GLPQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLPQ_ECOLI pepinfo swissprot:GLPQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLPQ_ECOLI pepnet swissprot:GLPQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLPQ_ECOLI pepstats swissprot:GLPQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLPQ_ECOLI pepwheel swissprot:GLPQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLPQ_ECOLI pepwindow swissprot:GLPQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLPQ_ECOLI sigcleave swissprot:GLPQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLPQ_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES GUDX_ECOLI Kinetic parameters KM=170 uM for idarate {ECO 0000269|PubMed 9772162}; KM=320 uM for glucarate {ECO 0000269|PubMed 9772162}; # BioGrid 4260899 20 # COFACTOR Name=a divalent metal cation; Xref=ChEBI:CHEBI 60240; Evidence={ECO:0000250}; # EcoGene EG13168 gudX # FUNCTION GUDX_ECOLI Does not seem to have an in-vivo activity on glucarate or idarate. Its real substrate is unknown. # GO_function GO:0016829 lyase activity; IEA:UniProtKB-KW. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0009063 cellular amino acid catabolic process; IEA:InterPro. # GO_process GO:0044248 cellular catabolic process; ISS:EcoCyc. # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # Gene3D 3.20.20.120 -; 1. # Gene3D 3.30.390.10 -; 1. # IntAct Q46915 3 # InterPro IPR001354 MR/MLE/MAL # InterPro IPR013341 Mandelate_racemase_N_dom # InterPro IPR013342 Mandelate_racemase_C # InterPro IPR018110 Mandel_Rmase/mucon_lact_enz_CS # InterPro IPR029017 Enolase_N-like # InterPro IPR029065 Enolase_C-like # Organism GUDX_ECOLI Escherichia coli (strain K12) # PANTHER PTHR13794 PTHR13794; 2 # PATRIC 32120992 VBIEscCol129921_2888 # PDB 4GYP X-ray; 2.10 A; C/D=2-446 # PDB 4IL0 X-ray; 2.80 A; A/B/C/D/E/F/G/H=1-446 # PIR H65060 H65060 # PROSITE PS00908 MR_MLE_1 # Pfam PF02746 MR_MLE_N # Pfam PF13378 MR_MLE_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GUDX_ECOLI Glucarate dehydratase-related protein # RefSeq NP_417268 NC_000913.3 # RefSeq WP_000235391 NZ_LN832404.1 # SIMILARITY Belongs to the mandelate racemase/muconate lactonizing enzyme family. GlucD subfamily. {ECO 0000305}. # SMART SM00922 MR_MLE # SUPFAM SSF51604 SSF51604 # SUPFAM SSF54826 SSF54826 # eggNOG COG4948 LUCA # eggNOG ENOG4105EQX Bacteria BLAST swissprot:GUDX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GUDX_ECOLI BioCyc ECOL316407:JW2759-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2759-MONOMER BioCyc EcoCyc:G7446-MONOMER http://biocyc.org/getid?id=EcoCyc:G7446-MONOMER COG COG4948 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4948 DOI 10.1021/bi981124f http://dx.doi.org/10.1021/bi981124f DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.1.- http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 ENZYME 4.2.1.- http://enzyme.expasy.org/EC/4.2.1.- EchoBASE EB2960 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2960 EcoGene EG13168 http://www.ecogene.org/geneInfo.php?eg_id=EG13168 EnsemblBacteria AAC75830 http://www.ensemblgenomes.org/id/AAC75830 EnsemblBacteria AAC75830 http://www.ensemblgenomes.org/id/AAC75830 EnsemblBacteria BAE76860 http://www.ensemblgenomes.org/id/BAE76860 EnsemblBacteria BAE76860 http://www.ensemblgenomes.org/id/BAE76860 EnsemblBacteria BAE76860 http://www.ensemblgenomes.org/id/BAE76860 EnsemblBacteria b2788 http://www.ensemblgenomes.org/id/b2788 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0009063 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009063 GO_process GO:0044248 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044248 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 3.20.20.120 http://www.cathdb.info/version/latest/superfamily/3.20.20.120 Gene3D 3.30.390.10 http://www.cathdb.info/version/latest/superfamily/3.30.390.10 GeneID 947261 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947261 HOGENOM HOG000238021 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000238021&db=HOGENOM6 InParanoid Q46915 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46915 IntAct Q46915 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46915* IntEnz 4.2.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1 InterPro IPR001354 http://www.ebi.ac.uk/interpro/entry/IPR001354 InterPro IPR013341 http://www.ebi.ac.uk/interpro/entry/IPR013341 InterPro IPR013342 http://www.ebi.ac.uk/interpro/entry/IPR013342 InterPro IPR018110 http://www.ebi.ac.uk/interpro/entry/IPR018110 InterPro IPR029017 http://www.ebi.ac.uk/interpro/entry/IPR029017 InterPro IPR029065 http://www.ebi.ac.uk/interpro/entry/IPR029065 KEGG_Gene ecj:JW2759 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2759 KEGG_Gene eco:b2788 http://www.genome.jp/dbget-bin/www_bget?eco:b2788 KEGG_Orthology KO:K13918 http://www.genome.jp/dbget-bin/www_bget?KO:K13918 OMA REMNHAL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=REMNHAL PANTHER PTHR13794 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13794 PDB 4GYP http://www.ebi.ac.uk/pdbe-srv/view/entry/4GYP PDB 4IL0 http://www.ebi.ac.uk/pdbe-srv/view/entry/4IL0 PDBsum 4GYP http://www.ebi.ac.uk/pdbsum/4GYP PDBsum 4IL0 http://www.ebi.ac.uk/pdbsum/4IL0 PROSITE PS00908 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00908 PSORT swissprot:GUDX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GUDX_ECOLI PSORT-B swissprot:GUDX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GUDX_ECOLI PSORT2 swissprot:GUDX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GUDX_ECOLI Pfam PF02746 http://pfam.xfam.org/family/PF02746 Pfam PF13378 http://pfam.xfam.org/family/PF13378 Phobius swissprot:GUDX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GUDX_ECOLI PhylomeDB Q46915 http://phylomedb.org/?seqid=Q46915 ProteinModelPortal Q46915 http://www.proteinmodelportal.org/query/uniprot/Q46915 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9772162 http://www.ncbi.nlm.nih.gov/pubmed/9772162 RefSeq NP_417268 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417268 RefSeq WP_000235391 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000235391 SMART SM00922 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00922 SMR Q46915 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46915 STRING 511145.b2788 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2788&targetmode=cogs STRING COG4948 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4948&targetmode=cogs SUPFAM SSF51604 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51604 SUPFAM SSF54826 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54826 UniProtKB GUDX_ECOLI http://www.uniprot.org/uniprot/GUDX_ECOLI UniProtKB-AC Q46915 http://www.uniprot.org/uniprot/Q46915 charge swissprot:GUDX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GUDX_ECOLI eggNOG COG4948 http://eggnogapi.embl.de/nog_data/html/tree/COG4948 eggNOG ENOG4105EQX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EQX epestfind swissprot:GUDX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GUDX_ECOLI garnier swissprot:GUDX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GUDX_ECOLI helixturnhelix swissprot:GUDX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GUDX_ECOLI hmoment swissprot:GUDX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GUDX_ECOLI iep swissprot:GUDX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GUDX_ECOLI inforesidue swissprot:GUDX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GUDX_ECOLI octanol swissprot:GUDX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GUDX_ECOLI pepcoil swissprot:GUDX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GUDX_ECOLI pepdigest swissprot:GUDX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GUDX_ECOLI pepinfo swissprot:GUDX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GUDX_ECOLI pepnet swissprot:GUDX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GUDX_ECOLI pepstats swissprot:GUDX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GUDX_ECOLI pepwheel swissprot:GUDX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GUDX_ECOLI pepwindow swissprot:GUDX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GUDX_ECOLI sigcleave swissprot:GUDX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GUDX_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES GPMI_ECOLI Kinetic parameters KM=210 uM for 3-PGA (at pH 7 and 30 degrees Celsius) {ECO 0000269|PubMed 10437801}; KM=97 uM for 2-PGA (at pH 7 and 30 degrees Celsius) {ECO 0000269|PubMed 10437801}; Note=Kcat is 22 sec(-1) for mutase with 3-PGA as substrate (at pH 7 and 30 degrees Celsius). Kcat is 10 sec(-1) for mutase with 2-PGA as substrate (at pH 7 and 30 degrees Celsius). {ECO 0000269|PubMed 10437801}; # BioGrid 4263294 13 # CATALYTIC ACTIVITY 2-phospho-D-glycerate = 3-phospho-D-glycerate. {ECO:0000269|PubMed 10437801}. # COFACTOR GPMI_ECOLI Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 10437801}; Note=Binds 2 manganese ions per subunit. {ECO 0000269|PubMed 10437801}; # DEVELOPMENTAL STAGE Expressed most strongly in early exponential growth, with levels falling off as cells reached late log phase and stationary phase. {ECO:0000269|PubMed 10437801}. # ENZYME REGULATION Insensitive to vanadate. {ECO:0000269|PubMed 10437801}. # EcoGene EG12296 gpmI # FUNCTION GPMI_ECOLI Catalyzes the interconversion of 2-phosphoglycerate (2- PGA) and 3-phosphoglycerate (3-PGA). {ECO 0000269|PubMed 10437801}. # GO_component GO:0005737 cytoplasm; IDA:UniProtKB. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0030145 manganese ion binding; IDA:EcoCyc. # GO_function GO:0046537 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity; IDA:EcoCyc. # GO_process GO:0006007 glucose catabolic process; IEA:InterPro. # GO_process GO:0006096 glycolytic process; IEA:UniProtKB-HAMAP. # GO_process GO:0006979 response to oxidative stress; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.1450.10 -; 1. # Gene3D 3.40.720.10 -; 2. # HAMAP MF_01038 GpmI # IntAct P37689 4 # InterPro IPR005995 Pgm_bpd_ind # InterPro IPR006124 Metalloenzyme # InterPro IPR011258 BPG-indep_PGM_N # InterPro IPR017849 Alkaline_Pase-like_a/b/a # InterPro IPR017850 Alkaline_phosphatase_core # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00010 Glycolysis / Gluconeogenesis # KEGG_Pathway ko00260 Glycine, serine and threonine metabolism # KEGG_Pathway ko00680 Methane metabolism # MISCELLANEOUS Inhibition by vanadate is a diagnostic test for discrimination between the cofactor-dependent (GpmA) and -independent (GpmI) phosphoglycerate mutases. {ECO:0000269|PubMed 10437801}. # Organism GPMI_ECOLI Escherichia coli (strain K12) # PATHWAY Carbohydrate degradation; glycolysis; pyruvate from D- glyceraldehyde 3-phosphate: step 3/5. {ECO 0000305}. # PATRIC 32122711 VBIEscCol129921_3732 # PIR S47833 S47833 # PIRSF PIRSF001492 IPGAM # Pfam PF01676 Metalloenzyme # Pfam PF06415 iPGM_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 2,3-bisphosphoglycerate-independent phosphoglycerate mutase {ECO:0000303|PubMed 10437801} # RefSeq NP_418069 NC_000913.3 # RefSeq WP_001350558 NZ_LN832404.1 # SIMILARITY Belongs to the BPG-independent phosphoglycerate mutase family. {ECO 0000305}. # SUBUNIT Monomer. {ECO:0000269|PubMed 10437801}. # SUPFAM SSF53649 SSF53649; 2 # SUPFAM SSF64158 SSF64158 # TIGRFAMs TIGR01307 pgm_bpd_ind # UniPathway UPA00109 UER00186 # eggNOG COG0696 LUCA # eggNOG ENOG4105CJI Bacteria BLAST swissprot:GPMI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GPMI_ECOLI BioCyc ECOL316407:JW3587-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3587-MONOMER BioCyc EcoCyc:PGMI-MONOMER http://biocyc.org/getid?id=EcoCyc:PGMI-MONOMER BioCyc MetaCyc:PGMI-MONOMER http://biocyc.org/getid?id=MetaCyc:PGMI-MONOMER COG COG0696 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0696 DIP DIP-12425N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12425N DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1016/S0014-5793(99)00910-2 http://dx.doi.org/10.1016/S0014-5793(99)00910-2 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.4.2.12 {ECO:0000269|PubMed:10437801} http://www.genome.jp/dbget-bin/www_bget?EC:5.4.2.12 {ECO:0000269|PubMed:10437801} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 5.4.2.12 {ECO:0000269|PubMed:10437801} http://enzyme.expasy.org/EC/5.4.2.12 {ECO:0000269|PubMed:10437801} EchoBASE EB2204 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2204 EcoGene EG12296 http://www.ecogene.org/geneInfo.php?eg_id=EG12296 EnsemblBacteria AAC76636 http://www.ensemblgenomes.org/id/AAC76636 EnsemblBacteria AAC76636 http://www.ensemblgenomes.org/id/AAC76636 EnsemblBacteria BAE77680 http://www.ensemblgenomes.org/id/BAE77680 EnsemblBacteria BAE77680 http://www.ensemblgenomes.org/id/BAE77680 EnsemblBacteria BAE77680 http://www.ensemblgenomes.org/id/BAE77680 EnsemblBacteria b3612 http://www.ensemblgenomes.org/id/b3612 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_function GO:0046537 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046537 GO_process GO:0006007 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006007 GO_process GO:0006096 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006096 GO_process GO:0006979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.1450.10 http://www.cathdb.info/version/latest/superfamily/3.40.1450.10 Gene3D 3.40.720.10 http://www.cathdb.info/version/latest/superfamily/3.40.720.10 GeneID 948130 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948130 HAMAP MF_01038 http://hamap.expasy.org/unirule/MF_01038 HOGENOM HOG000223664 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000223664&db=HOGENOM6 InParanoid P37689 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37689 IntAct P37689 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37689* IntEnz 5.4.2.12 {ECO:0000269|PubMed:10437801} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.4.2.12 {ECO:0000269|PubMed:10437801} InterPro IPR005995 http://www.ebi.ac.uk/interpro/entry/IPR005995 InterPro IPR006124 http://www.ebi.ac.uk/interpro/entry/IPR006124 InterPro IPR011258 http://www.ebi.ac.uk/interpro/entry/IPR011258 InterPro IPR017849 http://www.ebi.ac.uk/interpro/entry/IPR017849 InterPro IPR017850 http://www.ebi.ac.uk/interpro/entry/IPR017850 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3587 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3587 KEGG_Gene eco:b3612 http://www.genome.jp/dbget-bin/www_bget?eco:b3612 KEGG_Orthology KO:K15633 http://www.genome.jp/dbget-bin/www_bget?KO:K15633 KEGG_Pathway ko00010 http://www.genome.jp/kegg-bin/show_pathway?ko00010 KEGG_Pathway ko00260 http://www.genome.jp/kegg-bin/show_pathway?ko00260 KEGG_Pathway ko00680 http://www.genome.jp/kegg-bin/show_pathway?ko00680 KEGG_Reaction rn:R01518 http://www.genome.jp/dbget-bin/www_bget?rn:R01518 OMA LHIATMT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LHIATMT PSORT swissprot:GPMI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GPMI_ECOLI PSORT-B swissprot:GPMI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GPMI_ECOLI PSORT2 swissprot:GPMI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GPMI_ECOLI Pfam PF01676 http://pfam.xfam.org/family/PF01676 Pfam PF06415 http://pfam.xfam.org/family/PF06415 Phobius swissprot:GPMI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GPMI_ECOLI PhylomeDB P37689 http://phylomedb.org/?seqid=P37689 ProteinModelPortal P37689 http://www.proteinmodelportal.org/query/uniprot/P37689 PubMed 10437801 http://www.ncbi.nlm.nih.gov/pubmed/10437801 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418069 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418069 RefSeq WP_001350558 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001350558 SMR P37689 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37689 STRING 511145.b3612 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3612&targetmode=cogs STRING COG0696 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0696&targetmode=cogs SUPFAM SSF53649 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53649 SUPFAM SSF64158 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF64158 SWISS-2DPAGE P37689 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P37689 TIGRFAMs TIGR01307 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01307 UniProtKB GPMI_ECOLI http://www.uniprot.org/uniprot/GPMI_ECOLI UniProtKB-AC P37689 http://www.uniprot.org/uniprot/P37689 charge swissprot:GPMI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GPMI_ECOLI eggNOG COG0696 http://eggnogapi.embl.de/nog_data/html/tree/COG0696 eggNOG ENOG4105CJI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CJI epestfind swissprot:GPMI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GPMI_ECOLI garnier swissprot:GPMI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GPMI_ECOLI helixturnhelix swissprot:GPMI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GPMI_ECOLI hmoment swissprot:GPMI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GPMI_ECOLI iep swissprot:GPMI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GPMI_ECOLI inforesidue swissprot:GPMI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GPMI_ECOLI octanol swissprot:GPMI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GPMI_ECOLI pepcoil swissprot:GPMI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GPMI_ECOLI pepdigest swissprot:GPMI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GPMI_ECOLI pepinfo swissprot:GPMI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GPMI_ECOLI pepnet swissprot:GPMI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GPMI_ECOLI pepstats swissprot:GPMI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GPMI_ECOLI pepwheel swissprot:GPMI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GPMI_ECOLI pepwindow swissprot:GPMI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GPMI_ECOLI sigcleave swissprot:GPMI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GPMI_ECOLI ## Database ID URL or Descriptions # BRENDA 4.3.1 2026 # BioGrid 4262692 12 # CATALYTIC ACTIVITY ASPA_ECOLI L-aspartate = fumarate + NH(3). # EcoGene EG10095 aspA # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0008797 aspartate ammonia-lyase activity; IDA:EcoCyc. # GO_process GO:0006531 aspartate metabolic process; IDA:EcoCyc. # GO_process GO:0008652 cellular amino acid biosynthetic process; IDA:EcoCyc. # GO_process GO:0051262 protein tetramerization; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 1.10.275.10 -; 1. # INTERACTION ASPA_ECOLI P0A6Y8 dnaK; NbExp=2; IntAct=EBI-544200, EBI-542092; # IntAct P0AC38 12 # InterPro IPR000362 Fumarate_lyase_fam # InterPro IPR004708 ApsA # InterPro IPR008948 L-Aspartase-like # InterPro IPR018951 Fumarase_C_C # InterPro IPR020557 Fumarate_lyase_CS # InterPro IPR022761 Fumarate_lyase_N # InterPro IPR024083 Fumarase/histidase_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00250 Alanine, aspartate and glutamate metabolism # KEGG_Pathway ko00910 Nitrogen metabolism # Organism ASPA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11444 PTHR11444 # PATRIC 32123845 VBIEscCol129921_4270 # PDB 1JSW X-ray; 2.70 A; A/B/C/D=1-478 # PIR A01159 UFECDW # PRINTS PR00149 FUMRATELYASE # PROSITE PS00163 FUMARATE_LYASES # Pfam PF00206 Lyase_1 # Pfam PF10415 FumaraseC_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ASPA_ECOLI Aspartate ammonia-lyase # RefSeq NP_418562 NC_000913.3 # RefSeq WP_000069437 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97038.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the class-II fumarase/aspartase family. Aspartase subfamily. {ECO 0000305}. # SUBUNIT Homotetramer. {ECO:0000269|PubMed 9230045}. # SUPFAM SSF48557 SSF48557 # TIGRFAMs TIGR00839 aspA # eggNOG COG1027 LUCA # eggNOG ENOG4108IJ0 Bacteria BLAST swissprot:ASPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ASPA_ECOLI BioCyc ECOL316407:JW4099-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4099-MONOMER BioCyc EcoCyc:ASPARTASE-MONOMER http://biocyc.org/getid?id=EcoCyc:ASPARTASE-MONOMER BioCyc MetaCyc:ASPARTASE-MONOMER http://biocyc.org/getid?id=MetaCyc:ASPARTASE-MONOMER COG COG1027 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1027 DIP DIP-36166N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36166N DOI 10.1021/bi9704515 http://dx.doi.org/10.1021/bi9704515 DOI 10.1021/bi970452x http://dx.doi.org/10.1021/bi970452x DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2370547 http://dx.doi.org/10.1042/bj2370547 DOI 10.1093/nar/13.6.2063 http://dx.doi.org/10.1093/nar/13.6.2063 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.3.1.1 http://www.genome.jp/dbget-bin/www_bget?EC:4.3.1.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X02307 http://www.ebi.ac.uk/ena/data/view/X02307 EMBL X04066 http://www.ebi.ac.uk/ena/data/view/X04066 ENZYME 4.3.1.1 http://enzyme.expasy.org/EC/4.3.1.1 EchoBASE EB0093 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0093 EcoGene EG10095 http://www.ecogene.org/geneInfo.php?eg_id=EG10095 EnsemblBacteria AAC77099 http://www.ensemblgenomes.org/id/AAC77099 EnsemblBacteria AAC77099 http://www.ensemblgenomes.org/id/AAC77099 EnsemblBacteria BAE78141 http://www.ensemblgenomes.org/id/BAE78141 EnsemblBacteria BAE78141 http://www.ensemblgenomes.org/id/BAE78141 EnsemblBacteria BAE78141 http://www.ensemblgenomes.org/id/BAE78141 EnsemblBacteria b4139 http://www.ensemblgenomes.org/id/b4139 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0008797 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008797 GO_process GO:0006531 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006531 GO_process GO:0008652 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008652 GO_process GO:0051262 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051262 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 1.10.275.10 http://www.cathdb.info/version/latest/superfamily/1.10.275.10 GeneID 948658 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948658 HOGENOM HOG000061737 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000061737&db=HOGENOM6 InParanoid P0AC38 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AC38 IntAct P0AC38 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AC38* IntEnz 4.3.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.3.1.1 InterPro IPR000362 http://www.ebi.ac.uk/interpro/entry/IPR000362 InterPro IPR004708 http://www.ebi.ac.uk/interpro/entry/IPR004708 InterPro IPR008948 http://www.ebi.ac.uk/interpro/entry/IPR008948 InterPro IPR018951 http://www.ebi.ac.uk/interpro/entry/IPR018951 InterPro IPR020557 http://www.ebi.ac.uk/interpro/entry/IPR020557 InterPro IPR022761 http://www.ebi.ac.uk/interpro/entry/IPR022761 InterPro IPR024083 http://www.ebi.ac.uk/interpro/entry/IPR024083 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4099 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4099 KEGG_Gene eco:b4139 http://www.genome.jp/dbget-bin/www_bget?eco:b4139 KEGG_Orthology KO:K01744 http://www.genome.jp/dbget-bin/www_bget?KO:K01744 KEGG_Pathway ko00250 http://www.genome.jp/kegg-bin/show_pathway?ko00250 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Reaction rn:R00490 http://www.genome.jp/dbget-bin/www_bget?rn:R00490 MINT MINT-1258501 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1258501 OMA EICENYV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EICENYV PANTHER PTHR11444 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11444 PDB 1JSW http://www.ebi.ac.uk/pdbe-srv/view/entry/1JSW PDBsum 1JSW http://www.ebi.ac.uk/pdbsum/1JSW PRINTS PR00149 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00149 PROSITE PS00163 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00163 PSORT swissprot:ASPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ASPA_ECOLI PSORT-B swissprot:ASPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ASPA_ECOLI PSORT2 swissprot:ASPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ASPA_ECOLI Pfam PF00206 http://pfam.xfam.org/family/PF00206 Pfam PF10415 http://pfam.xfam.org/family/PF10415 Phobius swissprot:ASPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ASPA_ECOLI PhylomeDB P0AC38 http://phylomedb.org/?seqid=P0AC38 ProteinModelPortal P0AC38 http://www.proteinmodelportal.org/query/uniprot/P0AC38 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2987841 http://www.ncbi.nlm.nih.gov/pubmed/2987841 PubMed 3541901 http://www.ncbi.nlm.nih.gov/pubmed/3541901 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8119980 http://www.ncbi.nlm.nih.gov/pubmed/8119980 PubMed 9230045 http://www.ncbi.nlm.nih.gov/pubmed/9230045 PubMed 9230046 http://www.ncbi.nlm.nih.gov/pubmed/9230046 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418562 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418562 RefSeq WP_000069437 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000069437 SMR P0AC38 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AC38 STRING 511145.b4139 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4139&targetmode=cogs STRING COG1027 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1027&targetmode=cogs SUPFAM SSF48557 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48557 TIGRFAMs TIGR00839 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00839 UniProtKB ASPA_ECOLI http://www.uniprot.org/uniprot/ASPA_ECOLI UniProtKB-AC P0AC38 http://www.uniprot.org/uniprot/P0AC38 charge swissprot:ASPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ASPA_ECOLI eggNOG COG1027 http://eggnogapi.embl.de/nog_data/html/tree/COG1027 eggNOG ENOG4108IJ0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108IJ0 epestfind swissprot:ASPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ASPA_ECOLI garnier swissprot:ASPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ASPA_ECOLI helixturnhelix swissprot:ASPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ASPA_ECOLI hmoment swissprot:ASPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ASPA_ECOLI iep swissprot:ASPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ASPA_ECOLI inforesidue swissprot:ASPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ASPA_ECOLI octanol swissprot:ASPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ASPA_ECOLI pepcoil swissprot:ASPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ASPA_ECOLI pepdigest swissprot:ASPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ASPA_ECOLI pepinfo swissprot:ASPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ASPA_ECOLI pepnet swissprot:ASPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ASPA_ECOLI pepstats swissprot:ASPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ASPA_ECOLI pepwheel swissprot:ASPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ASPA_ECOLI pepwindow swissprot:ASPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ASPA_ECOLI sigcleave swissprot:ASPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ASPA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259876 281 # EcoGene EG13630 ybcN # GO_function GO:0000405 bubble DNA binding; IDA:EcoCyc. # GO_function GO:0003697 single-stranded DNA binding; IDA:EcoCyc. # GOslim_function GO:0003677 DNA binding # Gene3D 1.10.3790.10 -; 1. # IntAct Q47269 7 # InterPro IPR008711 Recombinase_NinB # MISCELLANEOUS YBCN_ECOLI Encoded by the cryptic lambdoid prophage DLP12. # Organism YBCN_ECOLI Escherichia coli (strain K12) # PATRIC 32116258 VBIEscCol129921_0569 # PIR S66587 S66587 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBCN_ECOLI Uncharacterized protein YbcN # RefSeq NP_415079 NC_000913.3 # RefSeq WP_001054340 NZ_LN832404.1 # SIMILARITY To equivalent protein in phage 82. {ECO 0000305}. # SUPFAM SSF103370 SSF103370 # eggNOG ENOG4108V2F Bacteria # eggNOG ENOG4111N1P LUCA BLAST swissprot:YBCN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBCN_ECOLI BioCyc ECOL316407:JW0535-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0535-MONOMER BioCyc EcoCyc:G6303-MONOMER http://biocyc.org/getid?id=EcoCyc:G6303-MONOMER DOI 10.1006/jmbi.1996.0185 http://dx.doi.org/10.1006/jmbi.1996.0185 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EMBL X92587 http://www.ebi.ac.uk/ena/data/view/X92587 EchoBASE EB3395 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3395 EcoGene EG13630 http://www.ecogene.org/geneInfo.php?eg_id=EG13630 EnsemblBacteria AAC73648 http://www.ensemblgenomes.org/id/AAC73648 EnsemblBacteria AAC73648 http://www.ensemblgenomes.org/id/AAC73648 EnsemblBacteria BAE76322 http://www.ensemblgenomes.org/id/BAE76322 EnsemblBacteria BAE76322 http://www.ensemblgenomes.org/id/BAE76322 EnsemblBacteria BAE76322 http://www.ensemblgenomes.org/id/BAE76322 EnsemblBacteria b0547 http://www.ensemblgenomes.org/id/b0547 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000405 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000405 GO_function GO:0003697 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003697 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 Gene3D 1.10.3790.10 http://www.cathdb.info/version/latest/superfamily/1.10.3790.10 GeneID 945162 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945162 HOGENOM HOG000267847 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267847&db=HOGENOM6 IntAct Q47269 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q47269* InterPro IPR008711 http://www.ebi.ac.uk/interpro/entry/IPR008711 KEGG_Gene ecj:JW0535 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0535 KEGG_Gene eco:b0547 http://www.genome.jp/dbget-bin/www_bget?eco:b0547 OMA GEMYIFL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GEMYIFL PSORT swissprot:YBCN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBCN_ECOLI PSORT-B swissprot:YBCN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBCN_ECOLI PSORT2 swissprot:YBCN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBCN_ECOLI Phobius swissprot:YBCN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBCN_ECOLI ProteinModelPortal Q47269 http://www.proteinmodelportal.org/query/uniprot/Q47269 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8648624 http://www.ncbi.nlm.nih.gov/pubmed/8648624 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415079 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415079 RefSeq WP_001054340 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001054340 SMR Q47269 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q47269 STRING 511145.b0547 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0547&targetmode=cogs SUPFAM SSF103370 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103370 UniProtKB YBCN_ECOLI http://www.uniprot.org/uniprot/YBCN_ECOLI UniProtKB-AC Q47269 http://www.uniprot.org/uniprot/Q47269 charge swissprot:YBCN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBCN_ECOLI eggNOG ENOG4108V2F http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108V2F eggNOG ENOG4111N1P http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111N1P epestfind swissprot:YBCN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBCN_ECOLI garnier swissprot:YBCN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBCN_ECOLI helixturnhelix swissprot:YBCN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBCN_ECOLI hmoment swissprot:YBCN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBCN_ECOLI iep swissprot:YBCN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBCN_ECOLI inforesidue swissprot:YBCN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBCN_ECOLI octanol swissprot:YBCN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBCN_ECOLI pepcoil swissprot:YBCN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBCN_ECOLI pepdigest swissprot:YBCN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBCN_ECOLI pepinfo swissprot:YBCN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBCN_ECOLI pepnet swissprot:YBCN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBCN_ECOLI pepstats swissprot:YBCN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBCN_ECOLI pepwheel swissprot:YBCN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBCN_ECOLI pepwindow swissprot:YBCN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBCN_ECOLI sigcleave swissprot:YBCN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBCN_ECOLI ## Database ID URL or Descriptions # BioGrid 4261318 8 # COFACTOR YPHC_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000250}; Note=Binds 2 Zn(2+) ions per subunit. {ECO 0000250}; # EcoGene EG13464 yphC # GO_function GO:0008270 zinc ion binding; IEA:InterPro. # GO_function GO:0016491 oxidoreductase activity; IEA:UniProtKB-KW. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.720 -; 1. # Gene3D 3.90.180.10 -; 1. # InterPro IPR002085 ADH_SF_Zn-type # InterPro IPR002328 ADH_Zn_CS # InterPro IPR011032 GroES-like # InterPro IPR013149 ADH_C # InterPro IPR013154 ADH_N # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR020843 PKS_ER # Organism YPHC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11695 PTHR11695 # PATRIC 32120487 VBIEscCol129921_2646 # PIR H65031 H65031 # PROSITE PS00059 ADH_ZINC # Pfam PF00107 ADH_zinc_N # Pfam PF08240 ADH_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YPHC_ECOLI Uncharacterized zinc-type alcohol dehydrogenase-like protein YphC # RefSeq NP_417040 NC_000913.3 # RefSeq WP_001393448 NZ_LN832404.1 # SIMILARITY Belongs to the zinc-containing alcohol dehydrogenase family. {ECO 0000305}. # SMART SM00829 PKS_ER # SUPFAM SSF50129 SSF50129; 2 # SUPFAM SSF51735 SSF51735 # eggNOG COG1063 LUCA # eggNOG ENOG4105CPQ Bacteria BLAST swissprot:YPHC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YPHC_ECOLI BioCyc ECOL316407:JW5842-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5842-MONOMER BioCyc EcoCyc:YPHC-MONOMER http://biocyc.org/getid?id=EcoCyc:YPHC-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- EchoBASE EB3237 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3237 EcoGene EG13464 http://www.ecogene.org/geneInfo.php?eg_id=EG13464 EnsemblBacteria AAC75598 http://www.ensemblgenomes.org/id/AAC75598 EnsemblBacteria AAC75598 http://www.ensemblgenomes.org/id/AAC75598 EnsemblBacteria BAA16447 http://www.ensemblgenomes.org/id/BAA16447 EnsemblBacteria BAA16447 http://www.ensemblgenomes.org/id/BAA16447 EnsemblBacteria BAA16447 http://www.ensemblgenomes.org/id/BAA16447 EnsemblBacteria b2545 http://www.ensemblgenomes.org/id/b2545 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 Gene3D 3.90.180.10 http://www.cathdb.info/version/latest/superfamily/3.90.180.10 GeneID 947019 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947019 HOGENOM HOG000294691 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000294691&db=HOGENOM6 InParanoid P77360 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77360 IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR002085 http://www.ebi.ac.uk/interpro/entry/IPR002085 InterPro IPR002328 http://www.ebi.ac.uk/interpro/entry/IPR002328 InterPro IPR011032 http://www.ebi.ac.uk/interpro/entry/IPR011032 InterPro IPR013149 http://www.ebi.ac.uk/interpro/entry/IPR013149 InterPro IPR013154 http://www.ebi.ac.uk/interpro/entry/IPR013154 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR020843 http://www.ebi.ac.uk/interpro/entry/IPR020843 KEGG_Gene ecj:JW5842 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5842 KEGG_Gene eco:b2545 http://www.genome.jp/dbget-bin/www_bget?eco:b2545 OMA ECHAGHQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ECHAGHQ PANTHER PTHR11695 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11695 PROSITE PS00059 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00059 PSORT swissprot:YPHC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YPHC_ECOLI PSORT-B swissprot:YPHC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YPHC_ECOLI PSORT2 swissprot:YPHC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YPHC_ECOLI Pfam PF00107 http://pfam.xfam.org/family/PF00107 Pfam PF08240 http://pfam.xfam.org/family/PF08240 Phobius swissprot:YPHC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YPHC_ECOLI PhylomeDB P77360 http://phylomedb.org/?seqid=P77360 ProteinModelPortal P77360 http://www.proteinmodelportal.org/query/uniprot/P77360 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417040 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417040 RefSeq WP_001393448 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001393448 SMART SM00829 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00829 SMR P77360 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77360 STRING 511145.b2545 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2545&targetmode=cogs SUPFAM SSF50129 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50129 SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB YPHC_ECOLI http://www.uniprot.org/uniprot/YPHC_ECOLI UniProtKB-AC P77360 http://www.uniprot.org/uniprot/P77360 charge swissprot:YPHC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YPHC_ECOLI eggNOG COG1063 http://eggnogapi.embl.de/nog_data/html/tree/COG1063 eggNOG ENOG4105CPQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CPQ epestfind swissprot:YPHC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YPHC_ECOLI garnier swissprot:YPHC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YPHC_ECOLI helixturnhelix swissprot:YPHC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YPHC_ECOLI hmoment swissprot:YPHC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YPHC_ECOLI iep swissprot:YPHC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YPHC_ECOLI inforesidue swissprot:YPHC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YPHC_ECOLI octanol swissprot:YPHC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YPHC_ECOLI pepcoil swissprot:YPHC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YPHC_ECOLI pepdigest swissprot:YPHC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YPHC_ECOLI pepinfo swissprot:YPHC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YPHC_ECOLI pepnet swissprot:YPHC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YPHC_ECOLI pepstats swissprot:YPHC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YPHC_ECOLI pepwheel swissprot:YPHC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YPHC_ECOLI pepwindow swissprot:YPHC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YPHC_ECOLI sigcleave swissprot:YPHC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YPHC_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES UACT_ECOLI Kinetic parameters KM=0.5 mM for uric acid {ECO 0000269|PubMed 22437829}; KM=0.3 mM for xanthine {ECO 0000269|PubMed 22437829}; Vmax=715 nmol/min/mg enzyme with acid uric as substrate {ECO 0000269|PubMed 22437829}; Vmax=14 nmol/min/mg enzyme with xanthine as substrate (at 37 degrees Celsius) {ECO 0000269|PubMed 22437829}; # BioGrid 4262336 160 # ENZYME REGULATION Inhibited in the presence of the protonophore carbonyl cyanide m-chlorophenyl hydrazone. {ECO:0000269|PubMed 22437829}. # EcoGene EG13071 uacT # FUNCTION UACT_ECOLI Proton-dependent high-capacity transporter for uric acid. Shows also a low capacity for transport of xanthine at 37 degrees Celsius but not at 25 degrees Celsius. {ECO 0000269|PubMed 22437829}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_function GO:0015143 urate transmembrane transporter activity; IMP:EcoCyc. # GO_function GO:0015293 symporter activity; IEA:UniProtKB-KW. # GO_function GO:0042907 xanthine transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0015747 urate transport; IMP:EcoCyc. # GO_process GO:0015992 proton transport; IEA:UniProtKB-KW. # GO_process GO:0042906 xanthine transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR006042 Xan_ur_permease # InterPro IPR006043 Xant/urac/vitC # InterPro IPR017588 UacT-like # Organism UACT_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11119 PTHR11119 # PATRIC 32121184 VBIEscCol129921_2980 # PIR H65072 H65072 # PROSITE PS01116 XANTH_URACIL_PERMASE # Pfam PF00860 Xan_ur_permease # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UACT_ECOLI Uric acid transporter UacT # RefSeq NP_417364 NC_000913.3 # RefSeq WP_001295374 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA83069.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION UACT_ECOLI Cell inner membrane {ECO 0000269|PubMed 22437829}; Multi-pass membrane protein {ECO 0000269|PubMed 22437829}. # TCDB 2.A.40.3:the nucleobase/ascorbate transporter (nat) or nucleobase cation symporter-2 (ncs2) family # TIGRFAMs TIGR00801 ncs2 # TIGRFAMs TIGR03173 pbuX # eggNOG COG2233 LUCA # eggNOG ENOG4105C2W Bacteria BLAST swissprot:UACT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UACT_ECOLI BioCyc ECOL316407:JW5470-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5470-MONOMER BioCyc EcoCyc:YGFU-MONOMER http://biocyc.org/getid?id=EcoCyc:YGFU-MONOMER BioCyc MetaCyc:YGFU-MONOMER http://biocyc.org/getid?id=MetaCyc:YGFU-MONOMER DIP DIP-12176N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12176N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M112.355818 http://dx.doi.org/10.1074/jbc.M112.355818 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 EchoBASE EB2882 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2882 EcoGene EG13071 http://www.ecogene.org/geneInfo.php?eg_id=EG13071 EnsemblBacteria AAC75926 http://www.ensemblgenomes.org/id/AAC75926 EnsemblBacteria AAC75926 http://www.ensemblgenomes.org/id/AAC75926 EnsemblBacteria BAE76953 http://www.ensemblgenomes.org/id/BAE76953 EnsemblBacteria BAE76953 http://www.ensemblgenomes.org/id/BAE76953 EnsemblBacteria BAE76953 http://www.ensemblgenomes.org/id/BAE76953 EnsemblBacteria b2888 http://www.ensemblgenomes.org/id/b2888 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015143 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015143 GO_function GO:0015293 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293 GO_function GO:0042907 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042907 GO_process GO:0015747 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015747 GO_process GO:0015992 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015992 GO_process GO:0042906 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042906 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 949017 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949017 HOGENOM HOG000038199 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000038199&db=HOGENOM6 InParanoid Q46821 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46821 InterPro IPR006042 http://www.ebi.ac.uk/interpro/entry/IPR006042 InterPro IPR006043 http://www.ebi.ac.uk/interpro/entry/IPR006043 InterPro IPR017588 http://www.ebi.ac.uk/interpro/entry/IPR017588 KEGG_Gene ecj:JW5470 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5470 KEGG_Gene eco:b2888 http://www.genome.jp/dbget-bin/www_bget?eco:b2888 OMA FYFGVPE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FYFGVPE PANTHER PTHR11119 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11119 PROSITE PS01116 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01116 PSORT swissprot:UACT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UACT_ECOLI PSORT-B swissprot:UACT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UACT_ECOLI PSORT2 swissprot:UACT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UACT_ECOLI Pfam PF00860 http://pfam.xfam.org/family/PF00860 Phobius swissprot:UACT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UACT_ECOLI PhylomeDB Q46821 http://phylomedb.org/?seqid=Q46821 ProteinModelPortal Q46821 http://www.proteinmodelportal.org/query/uniprot/Q46821 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22437829 http://www.ncbi.nlm.nih.gov/pubmed/22437829 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417364 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417364 RefSeq WP_001295374 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295374 STRING 511145.b2888 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2888&targetmode=cogs TCDB 2.A.40.3 http://www.tcdb.org/search/result.php?tc=2.A.40.3 TIGRFAMs TIGR00801 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00801 TIGRFAMs TIGR03173 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03173 UniProtKB UACT_ECOLI http://www.uniprot.org/uniprot/UACT_ECOLI UniProtKB-AC Q46821 http://www.uniprot.org/uniprot/Q46821 charge swissprot:UACT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UACT_ECOLI eggNOG COG2233 http://eggnogapi.embl.de/nog_data/html/tree/COG2233 eggNOG ENOG4105C2W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C2W epestfind swissprot:UACT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UACT_ECOLI garnier swissprot:UACT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UACT_ECOLI helixturnhelix swissprot:UACT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UACT_ECOLI hmoment swissprot:UACT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UACT_ECOLI iep swissprot:UACT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UACT_ECOLI inforesidue swissprot:UACT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UACT_ECOLI octanol swissprot:UACT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UACT_ECOLI pepcoil swissprot:UACT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UACT_ECOLI pepdigest swissprot:UACT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UACT_ECOLI pepinfo swissprot:UACT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UACT_ECOLI pepnet swissprot:UACT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UACT_ECOLI pepstats swissprot:UACT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UACT_ECOLI pepwheel swissprot:UACT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UACT_ECOLI pepwindow swissprot:UACT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UACT_ECOLI sigcleave swissprot:UACT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UACT_ECOLI ## Database ID URL or Descriptions # BioGrid 4262013 3 # CATALYTIC ACTIVITY ARCC_ECOLI ATP + NH(3) + CO(2) = ADP + carbamoyl phosphate. # CDD cd04235 AAK_CK # EcoGene EG12384 ybcF # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0008804 carbamate kinase activity; ISO:EcoCyc. # GO_process GO:0019546 arginine deiminase pathway; IBA:GO_Central. # GO_process GO:0035975 carbamoyl phosphate catabolic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.1160.10 -; 1. # IntAct P37306 3 # InterPro IPR001048 Asp/Glu/Uridylate_kinase # InterPro IPR003964 Carb_kinase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00330 Arginine and proline metabolism # KEGG_Pathway ko00910 Nitrogen metabolism # Organism ARCC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30409 PTHR30409 # PATHWAY Metabolic intermediate metabolism; carbamoyl phosphate degradation; CO(2) and NH(3) from carbamoyl phosphate step 1/1. # PATRIC 32116202 VBIEscCol129921_0542 # PIR H64783 H64783 # PIRSF PIRSF000723 Carbamate_kin # Pfam PF00696 AA_kinase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ARCC_ECOLI Carbamate kinase # RefSeq NP_415054 NC_000913.3 # RefSeq WP_000855379 NZ_LN832404.1 # SIMILARITY Belongs to the carbamate kinase family. {ECO 0000305}. # SUBCELLULAR LOCATION ARCC_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Homodimer. {ECO 0000250}. # SUPFAM SSF53633 SSF53633 # TIGRFAMs TIGR00746 arcC # UniPathway UPA00996 UER00366 # eggNOG COG0549 LUCA # eggNOG ENOG4105C5B Bacteria BLAST swissprot:ARCC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARCC_ECOLI BioCyc ECOL316407:JW0510-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0510-MONOMER BioCyc EcoCyc:EG12384-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12384-MONOMER COG COG0549 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0549 DOI 10.1016/0968-0004(94)90067-1 http://dx.doi.org/10.1016/0968-0004(94)90067-1 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/ng0694-205 http://dx.doi.org/10.1038/ng0694-205 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.2.2 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.2.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M19657 http://www.ebi.ac.uk/ena/data/view/M19657 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL X12982 http://www.ebi.ac.uk/ena/data/view/X12982 ENZYME 2.7.2.2 http://enzyme.expasy.org/EC/2.7.2.2 EchoBASE EB2285 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2285 EcoGene EG12384 http://www.ecogene.org/geneInfo.php?eg_id=EG12384 EnsemblBacteria AAC73623 http://www.ensemblgenomes.org/id/AAC73623 EnsemblBacteria AAC73623 http://www.ensemblgenomes.org/id/AAC73623 EnsemblBacteria BAE76298 http://www.ensemblgenomes.org/id/BAE76298 EnsemblBacteria BAE76298 http://www.ensemblgenomes.org/id/BAE76298 EnsemblBacteria BAE76298 http://www.ensemblgenomes.org/id/BAE76298 EnsemblBacteria b0521 http://www.ensemblgenomes.org/id/b0521 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008804 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008804 GO_process GO:0019546 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019546 GO_process GO:0035975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035975 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.1160.10 http://www.cathdb.info/version/latest/superfamily/3.40.1160.10 GeneID 944972 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944972 HOGENOM HOG000277403 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000277403&db=HOGENOM6 InParanoid P37306 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37306 IntAct P37306 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37306* IntEnz 2.7.2.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.2.2 InterPro IPR001048 http://www.ebi.ac.uk/interpro/entry/IPR001048 InterPro IPR003964 http://www.ebi.ac.uk/interpro/entry/IPR003964 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0510 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0510 KEGG_Gene eco:b0521 http://www.genome.jp/dbget-bin/www_bget?eco:b0521 KEGG_Orthology KO:K00926 http://www.genome.jp/dbget-bin/www_bget?KO:K00926 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00330 http://www.genome.jp/kegg-bin/show_pathway?ko00330 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Reaction rn:R00150 http://www.genome.jp/dbget-bin/www_bget?rn:R00150 KEGG_Reaction rn:R01395 http://www.genome.jp/dbget-bin/www_bget?rn:R01395 OMA YQLVIVH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YQLVIVH PANTHER PTHR30409 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30409 PSORT swissprot:ARCC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARCC_ECOLI PSORT-B swissprot:ARCC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARCC_ECOLI PSORT2 swissprot:ARCC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARCC_ECOLI Pfam PF00696 http://pfam.xfam.org/family/PF00696 Phobius swissprot:ARCC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARCC_ECOLI PhylomeDB P37306 http://phylomedb.org/?seqid=P37306 ProteinModelPortal P37306 http://www.proteinmodelportal.org/query/uniprot/P37306 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2464576 http://www.ncbi.nlm.nih.gov/pubmed/2464576 PubMed 2644189 http://www.ncbi.nlm.nih.gov/pubmed/2644189 PubMed 7920643 http://www.ncbi.nlm.nih.gov/pubmed/7920643 PubMed 7940673 http://www.ncbi.nlm.nih.gov/pubmed/7940673 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415054 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415054 RefSeq WP_000855379 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000855379 SMR P37306 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37306 STRING 511145.b0521 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0521&targetmode=cogs STRING COG0549 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0549&targetmode=cogs SUPFAM SSF53633 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53633 TIGRFAMs TIGR00746 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00746 UniProtKB ARCC_ECOLI http://www.uniprot.org/uniprot/ARCC_ECOLI UniProtKB-AC P37306 http://www.uniprot.org/uniprot/P37306 charge swissprot:ARCC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARCC_ECOLI eggNOG COG0549 http://eggnogapi.embl.de/nog_data/html/tree/COG0549 eggNOG ENOG4105C5B http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C5B epestfind swissprot:ARCC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARCC_ECOLI garnier swissprot:ARCC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARCC_ECOLI helixturnhelix swissprot:ARCC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARCC_ECOLI hmoment swissprot:ARCC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARCC_ECOLI iep swissprot:ARCC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARCC_ECOLI inforesidue swissprot:ARCC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARCC_ECOLI octanol swissprot:ARCC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARCC_ECOLI pepcoil swissprot:ARCC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARCC_ECOLI pepdigest swissprot:ARCC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARCC_ECOLI pepinfo swissprot:ARCC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARCC_ECOLI pepnet swissprot:ARCC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARCC_ECOLI pepstats swissprot:ARCC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARCC_ECOLI pepwheel swissprot:ARCC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARCC_ECOLI pepwindow swissprot:ARCC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARCC_ECOLI sigcleave swissprot:ARCC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARCC_ECOLI ## Database ID URL or Descriptions # BioGrid 4262914 6 # EcoGene EG11628 artJ # FUNCTION ARTJ_ECOLI Part of the ABC transporter complex ArtPIQMJ involved in arginine transport. Binds L-arginine with high affinity. {ECO 0000269|PubMed 8801422}. # GO_component GO:0016020 membrane; IEA:InterPro. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_component GO:0042597 periplasmic space; IDA:EcoliWiki. # GO_function GO:0004970 ionotropic glutamate receptor activity; IEA:InterPro. # GO_function GO:0016597 amino acid binding; IDA:EcoliWiki. # GO_function GO:0034618 arginine binding; IDA:EcoCyc. # GO_process GO:0015809 arginine transport; IMP:EcoliWiki. # GO_process GO:1902765 L-arginine import into cell; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # InterPro IPR001320 Iontro_rcpt # InterPro IPR001638 Solute-binding_3/MltF_N # InterPro IPR005768 Lys_Arg_Orn-bd # InterPro IPR018313 SBP_3_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00229 Arginine transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism ARTJ_ECOLI Escherichia coli (strain K12) # PATRIC 32116927 VBIEscCol129921_0889 # PIR D64824 D64824 # PROSITE PS01039 SBP_BACTERIAL_3 # Pfam PF00497 SBP_bac_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ARTJ_ECOLI ABC transporter arginine-binding protein 1 # RefSeq NP_415381 NC_000913.3 # RefSeq WP_001295339 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial solute-binding protein 3 family. {ECO 0000305}. # SMART SM00062 PBPb # SMART SM00079 PBPe # SUBCELLULAR LOCATION ARTJ_ECOLI Periplasm {ECO 0000269|PubMed 8801422}. # SUBUNIT The complex is composed of two ATP-binding proteins (ArtP), two transmembrane proteins (ArtM and ArtQ) and two solute- binding proteins (ArtJ and ArtI). {ECO:0000305|PubMed 8801422}. # TCDB 3.A.1.3 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR01096 3A0103s03R # eggNOG COG0834 LUCA # eggNOG ENOG4106TNF Bacteria BLAST swissprot:ARTJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARTJ_ECOLI BioCyc ECOL316407:JW0844-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0844-MONOMER BioCyc EcoCyc:ARTJ-MONOMER http://biocyc.org/getid?id=EcoCyc:ARTJ-MONOMER BioCyc MetaCyc:ARTJ-MONOMER http://biocyc.org/getid?id=MetaCyc:ARTJ-MONOMER COG COG0834 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0834 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1998.1726 http://dx.doi.org/10.1006/jmbi.1998.1726 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1995.mmi_17040675.x http://dx.doi.org/10.1111/j.1365-2958.1995.mmi_17040675.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X86160 http://www.ebi.ac.uk/ena/data/view/X86160 EchoBASE EB1585 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1585 EcoGene EG11628 http://www.ecogene.org/geneInfo.php?eg_id=EG11628 EnsemblBacteria AAC73947 http://www.ensemblgenomes.org/id/AAC73947 EnsemblBacteria AAC73947 http://www.ensemblgenomes.org/id/AAC73947 EnsemblBacteria BAA35574 http://www.ensemblgenomes.org/id/BAA35574 EnsemblBacteria BAA35574 http://www.ensemblgenomes.org/id/BAA35574 EnsemblBacteria BAA35574 http://www.ensemblgenomes.org/id/BAA35574 EnsemblBacteria b0860 http://www.ensemblgenomes.org/id/b0860 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0004970 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004970 GO_function GO:0016597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016597 GO_function GO:0034618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034618 GO_process GO:0015809 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015809 GO_process GO:1902765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902765 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948981 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948981 HOGENOM HOG000031896 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000031896&db=HOGENOM6 InParanoid P30860 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30860 IntAct P30860 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P30860* InterPro IPR001320 http://www.ebi.ac.uk/interpro/entry/IPR001320 InterPro IPR001638 http://www.ebi.ac.uk/interpro/entry/IPR001638 InterPro IPR005768 http://www.ebi.ac.uk/interpro/entry/IPR005768 InterPro IPR018313 http://www.ebi.ac.uk/interpro/entry/IPR018313 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0844 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0844 KEGG_Gene eco:b0860 http://www.genome.jp/dbget-bin/www_bget?eco:b0860 KEGG_Orthology KO:K09996 http://www.genome.jp/dbget-bin/www_bget?KO:K09996 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA QPYYANT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QPYYANT PROSITE PS01039 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01039 PSORT swissprot:ARTJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARTJ_ECOLI PSORT-B swissprot:ARTJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARTJ_ECOLI PSORT2 swissprot:ARTJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARTJ_ECOLI Pfam PF00497 http://pfam.xfam.org/family/PF00497 Phobius swissprot:ARTJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARTJ_ECOLI PhylomeDB P30860 http://phylomedb.org/?seqid=P30860 ProteinModelPortal P30860 http://www.proteinmodelportal.org/query/uniprot/P30860 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8501075 http://www.ncbi.nlm.nih.gov/pubmed/8501075 PubMed 8801422 http://www.ncbi.nlm.nih.gov/pubmed/8801422 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 RefSeq NP_415381 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415381 RefSeq WP_001295339 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295339 SMART SM00062 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00062 SMART SM00079 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00079 SMR P30860 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P30860 STRING 511145.b0860 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0860&targetmode=cogs STRING COG0834 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0834&targetmode=cogs SWISS-2DPAGE P30860 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P30860 TCDB 3.A.1.3 http://www.tcdb.org/search/result.php?tc=3.A.1.3 TIGRFAMs TIGR01096 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01096 UniProtKB ARTJ_ECOLI http://www.uniprot.org/uniprot/ARTJ_ECOLI UniProtKB-AC P30860 http://www.uniprot.org/uniprot/P30860 charge swissprot:ARTJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARTJ_ECOLI eggNOG COG0834 http://eggnogapi.embl.de/nog_data/html/tree/COG0834 eggNOG ENOG4106TNF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106TNF epestfind swissprot:ARTJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARTJ_ECOLI garnier swissprot:ARTJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARTJ_ECOLI helixturnhelix swissprot:ARTJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARTJ_ECOLI hmoment swissprot:ARTJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARTJ_ECOLI iep swissprot:ARTJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARTJ_ECOLI inforesidue swissprot:ARTJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARTJ_ECOLI octanol swissprot:ARTJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARTJ_ECOLI pepcoil swissprot:ARTJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARTJ_ECOLI pepdigest swissprot:ARTJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARTJ_ECOLI pepinfo swissprot:ARTJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARTJ_ECOLI pepnet swissprot:ARTJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARTJ_ECOLI pepstats swissprot:ARTJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARTJ_ECOLI pepwheel swissprot:ARTJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARTJ_ECOLI pepwindow swissprot:ARTJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARTJ_ECOLI sigcleave swissprot:ARTJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARTJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4261850 13 # CDD cd01540 PBP1_arabinose_binding # EcoGene EG10057 araF # FUNCTION ARAF_ECOLI Involved in the high-affinity L-arabinose membrane transport system. Binds with high affinity to arabinose, but can also bind D-galactose (approximately 2-fold reduction) and D- fucose (approximately 40-fold reduction). # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0015407 monosaccharide-transporting ATPase activity; IMP:EcoCyc. # GO_function GO:0048029 monosaccharide binding; IDA:EcoCyc. # GO_process GO:0042882 L-arabinose transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # IntAct P02924 5 # InterPro IPR001761 Peripla_BP/Lac1_sug-bd_dom # InterPro IPR026266 AraF # InterPro IPR028082 Peripla_BP_I # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00213 L-Arabinose transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism ARAF_ECOLI Escherichia coli (strain K12) # PATRIC 32119127 VBIEscCol129921_1981 # PDB 1ABE X-ray; 1.70 A; A=24-329 # PDB 1ABF X-ray; 1.90 A; A=24-329 # PDB 1APB X-ray; 1.76 A; A=24-329 # PDB 1BAP X-ray; 1.75 A; A=24-329 # PDB 2WRZ X-ray; 2.20 A; A/B=24-329 # PDB 5ABP X-ray; 1.80 A; A=24-329 # PDB 6ABP X-ray; 1.67 A; A=24-329 # PDB 7ABP X-ray; 1.67 A; A=24-329 # PDB 8ABP X-ray; 1.49 A; A=24-329 # PDB 9ABP X-ray; 1.97 A; A=24-329 # PIR E64953 JGECA # PIRSF PIRSF002816 AraF # Pfam PF00532 Peripla_BP_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ARAF_ECOLI L-arabinose-binding periplasmic protein # RefSeq NP_416414 NC_000913.3 # RefSeq WP_000548675 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial solute-binding protein 2 family. {ECO 0000305}. # SUBCELLULAR LOCATION ARAF_ECOLI Periplasm. # SUPFAM SSF53822 SSF53822 # TCDB 3.A.1.2 the atp-binding cassette (abc) superfamily # eggNOG COG1879 LUCA # eggNOG ENOG4105DMK Bacteria BLAST swissprot:ARAF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARAF_ECOLI BioCyc ECOL316407:JW1889-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1889-MONOMER BioCyc EcoCyc:ARAF-MONOMER http://biocyc.org/getid?id=EcoCyc:ARAF-MONOMER BioCyc MetaCyc:ARAF-MONOMER http://biocyc.org/getid?id=MetaCyc:ARAF-MONOMER COG COG1879 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1879 DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1016/0022-2836(87)90607-3 http://dx.doi.org/10.1016/0022-2836(87)90607-3 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K00420 http://www.ebi.ac.uk/ena/data/view/K00420 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X06091 http://www.ebi.ac.uk/ena/data/view/X06091 EchoBASE EB0055 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0055 EcoGene EG10057 http://www.ecogene.org/geneInfo.php?eg_id=EG10057 EnsemblBacteria AAC74971 http://www.ensemblgenomes.org/id/AAC74971 EnsemblBacteria AAC74971 http://www.ensemblgenomes.org/id/AAC74971 EnsemblBacteria BAA15721 http://www.ensemblgenomes.org/id/BAA15721 EnsemblBacteria BAA15721 http://www.ensemblgenomes.org/id/BAA15721 EnsemblBacteria BAA15721 http://www.ensemblgenomes.org/id/BAA15721 EnsemblBacteria b1901 http://www.ensemblgenomes.org/id/b1901 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0015407 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015407 GO_function GO:0048029 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048029 GO_process GO:0042882 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042882 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 946409 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946409 HOGENOM HOG000220638 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220638&db=HOGENOM6 IntAct P02924 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P02924* InterPro IPR001761 http://www.ebi.ac.uk/interpro/entry/IPR001761 InterPro IPR026266 http://www.ebi.ac.uk/interpro/entry/IPR026266 InterPro IPR028082 http://www.ebi.ac.uk/interpro/entry/IPR028082 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1889 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1889 KEGG_Gene eco:b1901 http://www.genome.jp/dbget-bin/www_bget?eco:b1901 KEGG_Orthology KO:K10537 http://www.genome.jp/dbget-bin/www_bget?KO:K10537 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA NDIPGAL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NDIPGAL PDB 1ABE http://www.ebi.ac.uk/pdbe-srv/view/entry/1ABE PDB 1ABF http://www.ebi.ac.uk/pdbe-srv/view/entry/1ABF PDB 1APB http://www.ebi.ac.uk/pdbe-srv/view/entry/1APB PDB 1BAP http://www.ebi.ac.uk/pdbe-srv/view/entry/1BAP PDB 2WRZ http://www.ebi.ac.uk/pdbe-srv/view/entry/2WRZ PDB 5ABP http://www.ebi.ac.uk/pdbe-srv/view/entry/5ABP PDB 6ABP http://www.ebi.ac.uk/pdbe-srv/view/entry/6ABP PDB 7ABP http://www.ebi.ac.uk/pdbe-srv/view/entry/7ABP PDB 8ABP http://www.ebi.ac.uk/pdbe-srv/view/entry/8ABP PDB 9ABP http://www.ebi.ac.uk/pdbe-srv/view/entry/9ABP PDBsum 1ABE http://www.ebi.ac.uk/pdbsum/1ABE PDBsum 1ABF http://www.ebi.ac.uk/pdbsum/1ABF PDBsum 1APB http://www.ebi.ac.uk/pdbsum/1APB PDBsum 1BAP http://www.ebi.ac.uk/pdbsum/1BAP PDBsum 2WRZ http://www.ebi.ac.uk/pdbsum/2WRZ PDBsum 5ABP http://www.ebi.ac.uk/pdbsum/5ABP PDBsum 6ABP http://www.ebi.ac.uk/pdbsum/6ABP PDBsum 7ABP http://www.ebi.ac.uk/pdbsum/7ABP PDBsum 8ABP http://www.ebi.ac.uk/pdbsum/8ABP PDBsum 9ABP http://www.ebi.ac.uk/pdbsum/9ABP PSORT swissprot:ARAF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARAF_ECOLI PSORT-B swissprot:ARAF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARAF_ECOLI PSORT2 swissprot:ARAF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARAF_ECOLI Pfam PF00532 http://pfam.xfam.org/family/PF00532 Phobius swissprot:ARAF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARAF_ECOLI PhylomeDB P02924 http://phylomedb.org/?seqid=P02924 ProteinModelPortal P02924 http://www.proteinmodelportal.org/query/uniprot/P02924 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2204627 http://www.ncbi.nlm.nih.gov/pubmed/2204627 PubMed 2445996 http://www.ncbi.nlm.nih.gov/pubmed/2445996 PubMed 326784 http://www.ncbi.nlm.nih.gov/pubmed/326784 PubMed 326785 http://www.ncbi.nlm.nih.gov/pubmed/326785 PubMed 6885805 http://www.ncbi.nlm.nih.gov/pubmed/6885805 PubMed 7031057 http://www.ncbi.nlm.nih.gov/pubmed/7031057 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_416414 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416414 RefSeq WP_000548675 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000548675 SMR P02924 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P02924 STRING 511145.b1901 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1901&targetmode=cogs STRING COG1879 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1879&targetmode=cogs SUPFAM SSF53822 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822 TCDB 3.A.1.2 http://www.tcdb.org/search/result.php?tc=3.A.1.2 UniProtKB ARAF_ECOLI http://www.uniprot.org/uniprot/ARAF_ECOLI UniProtKB-AC P02924 http://www.uniprot.org/uniprot/P02924 charge swissprot:ARAF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARAF_ECOLI eggNOG COG1879 http://eggnogapi.embl.de/nog_data/html/tree/COG1879 eggNOG ENOG4105DMK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DMK epestfind swissprot:ARAF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARAF_ECOLI garnier swissprot:ARAF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARAF_ECOLI helixturnhelix swissprot:ARAF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARAF_ECOLI hmoment swissprot:ARAF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARAF_ECOLI iep swissprot:ARAF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARAF_ECOLI inforesidue swissprot:ARAF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARAF_ECOLI octanol swissprot:ARAF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARAF_ECOLI pepcoil swissprot:ARAF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARAF_ECOLI pepdigest swissprot:ARAF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARAF_ECOLI pepinfo swissprot:ARAF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARAF_ECOLI pepnet swissprot:ARAF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARAF_ECOLI pepstats swissprot:ARAF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARAF_ECOLI pepwheel swissprot:ARAF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARAF_ECOLI pepwindow swissprot:ARAF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARAF_ECOLI sigcleave swissprot:ARAF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARAF_ECOLI ## Database ID URL or Descriptions # BioGrid 4260923 5 # EcoGene EG14191 eutP # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0046336 ethanolamine catabolic process; IEA:UniProtKB-UniPathway. # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.300 -; 1. # IntAct P76556 17 # InterPro IPR012381 EutP_PduV # InterPro IPR027417 P-loop_NTPase # Organism EUTP_ECOLI Escherichia coli (strain K12) # PATHWAY EUTP_ECOLI Amine and polyamine degradation; ethanolamine degradation. # PATRIC 32120305 VBIEscCol129921_2555 # PIR D65021 D65021 # PIRSF PIRSF036409 EutP_PduV # Pfam PF10662 PduV-EutP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EUTP_ECOLI Ethanolamine utilization protein EutP # RefSeq NP_416956 NC_000913.3 # RefSeq WP_000820763 NZ_LN832404.1 # SIMILARITY Belongs to the EutP/PduV family. {ECO 0000305}. # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR02528 EutP # eggNOG COG4917 LUCA # eggNOG ENOG4106S4J Bacteria BLAST swissprot:EUTP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EUTP_ECOLI BioCyc ECOL316407:JW2445-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2445-MONOMER BioCyc EcoCyc:G7291-MONOMER http://biocyc.org/getid?id=EcoCyc:G7291-MONOMER COG COG4917 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4917 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3943 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3943 EcoGene EG14191 http://www.ecogene.org/geneInfo.php?eg_id=EG14191 EnsemblBacteria AAC75514 http://www.ensemblgenomes.org/id/AAC75514 EnsemblBacteria AAC75514 http://www.ensemblgenomes.org/id/AAC75514 EnsemblBacteria BAE76719 http://www.ensemblgenomes.org/id/BAE76719 EnsemblBacteria BAE76719 http://www.ensemblgenomes.org/id/BAE76719 EnsemblBacteria BAE76719 http://www.ensemblgenomes.org/id/BAE76719 EnsemblBacteria b2461 http://www.ensemblgenomes.org/id/b2461 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0046336 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046336 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 946933 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946933 HOGENOM HOG000286391 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000286391&db=HOGENOM6 InParanoid P76556 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76556 IntAct P76556 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76556* InterPro IPR012381 http://www.ebi.ac.uk/interpro/entry/IPR012381 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Gene ecj:JW2445 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2445 KEGG_Gene eco:b2461 http://www.genome.jp/dbget-bin/www_bget?eco:b2461 KEGG_Orthology KO:K04029 http://www.genome.jp/dbget-bin/www_bget?KO:K04029 OMA EPIFALN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EPIFALN PSORT swissprot:EUTP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EUTP_ECOLI PSORT-B swissprot:EUTP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EUTP_ECOLI PSORT2 swissprot:EUTP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EUTP_ECOLI Pfam PF10662 http://pfam.xfam.org/family/PF10662 Phobius swissprot:EUTP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EUTP_ECOLI ProteinModelPortal P76556 http://www.proteinmodelportal.org/query/uniprot/P76556 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416956 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416956 RefSeq WP_000820763 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000820763 SMR P76556 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76556 STRING 511145.b2461 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2461&targetmode=cogs STRING COG4917 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4917&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR02528 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02528 UniProtKB EUTP_ECOLI http://www.uniprot.org/uniprot/EUTP_ECOLI UniProtKB-AC P76556 http://www.uniprot.org/uniprot/P76556 charge swissprot:EUTP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EUTP_ECOLI eggNOG COG4917 http://eggnogapi.embl.de/nog_data/html/tree/COG4917 eggNOG ENOG4106S4J http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106S4J epestfind swissprot:EUTP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EUTP_ECOLI garnier swissprot:EUTP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EUTP_ECOLI helixturnhelix swissprot:EUTP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EUTP_ECOLI hmoment swissprot:EUTP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EUTP_ECOLI iep swissprot:EUTP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EUTP_ECOLI inforesidue swissprot:EUTP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EUTP_ECOLI octanol swissprot:EUTP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EUTP_ECOLI pepcoil swissprot:EUTP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EUTP_ECOLI pepdigest swissprot:EUTP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EUTP_ECOLI pepinfo swissprot:EUTP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EUTP_ECOLI pepnet swissprot:EUTP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EUTP_ECOLI pepstats swissprot:EUTP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EUTP_ECOLI pepwheel swissprot:EUTP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EUTP_ECOLI pepwindow swissprot:EUTP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EUTP_ECOLI sigcleave swissprot:EUTP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EUTP_ECOLI ## Database ID URL or Descriptions # BRENDA 2.7.13 2026 # BioGrid 4260559 11 # CATALYTIC ACTIVITY EVGS_ECOLI ATP + protein L-histidine = ADP + protein N- phospho-L-histidine. # EcoGene EG11610 evgS # FUNCTION EVGS_ECOLI Member of the two-component regulatory system EvgS/EvgA. Phosphorylates EvgA via a four-step phosphorelay in response to environmental signals. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0000155 phosphorelay sensor kinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0009927 histidine phosphotransfer kinase activity; IMP:EcoCyc. # GO_process GO:0000160 phosphorelay signal transduction system; IDA:EcoCyc. # GO_process GO:0010447 response to acidic pH; IMP:EcoCyc. # GO_process GO:0046777 protein autophosphorylation; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005622 intracellular # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # Gene3D 1.10.287.130 -; 1. # Gene3D 1.20.120.160 -; 1. # Gene3D 3.30.565.10 -; 1. # IntAct P30855 3 # InterPro IPR001638 Solute-binding_3/MltF_N # InterPro IPR001789 Sig_transdc_resp-reg_receiver # InterPro IPR003594 HATPase_C # InterPro IPR003661 HisK_dim/P # InterPro IPR004358 Sig_transdc_His_kin-like_C # InterPro IPR005467 His_kinase_dom # InterPro IPR008207 Sig_transdc_His_kin_Hpt_dom # InterPro IPR011006 CheY-like_superfamily # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01001 Protein kinases # KEGG_Brite ko02022 M00477 EvgS-EvgA (acid and drug tolerance) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # KEGG_Pathway ko05133 Pertussis # Organism EVGS_ECOLI Escherichia coli (strain K12) # PATRIC 32120119 VBIEscCol129921_2468 # PIR G65010 G65010 # PRINTS PR00344 BCTRLSENSOR # PROSITE PS50109 HIS_KIN # PROSITE PS50110 RESPONSE_REGULATORY # PROSITE PS50894 HPT # PTM EVGS_ECOLI Activation requires a sequential transfer of a phosphate group from a His in the primary transmitter domain, to an Asp in the receiver domain and to a His in the secondary transmitter domain. # Pfam PF00072 Response_reg # Pfam PF00497 SBP_bac_3; 2 # Pfam PF00512 HisKA # Pfam PF01627 Hpt # Pfam PF02518 HATPase_c # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EVGS_ECOLI Sensor protein EvgS # RefSeq NP_416871 NC_000913.3 # SIMILARITY Contains 1 HPt domain. {ECO:0000255|PROSITE- ProRule PRU00110}. # SIMILARITY Contains 1 histidine kinase domain. {ECO:0000255|PROSITE-ProRule PRU00107}. # SIMILARITY Contains 1 response regulatory domain. {ECO:0000255|PROSITE-ProRule PRU00169}. # SMART SM00062 PBPb; 2 # SMART SM00073 HPT # SMART SM00387 HATPase_c # SMART SM00388 HisKA # SMART SM00448 REC # SUBCELLULAR LOCATION EVGS_ECOLI Cell inner membrane {ECO 0000305}; Multi- pass membrane protein {ECO 0000305}. # SUPFAM SSF47226 SSF47226 # SUPFAM SSF47384 SSF47384 # SUPFAM SSF52172 SSF52172 # SUPFAM SSF55874 SSF55874 # eggNOG COG0784 LUCA # eggNOG COG0834 LUCA # eggNOG COG2198 LUCA # eggNOG ENOG4105BZU Bacteria BLAST swissprot:EVGS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EVGS_ECOLI BioCyc ECOL316407:JW2367-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2367-MONOMER BioCyc EcoCyc:EVGS-MONOMER http://biocyc.org/getid?id=EcoCyc:EVGS-MONOMER DIP DIP-9545N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9545N DOI 10.1016/0378-1119(94)90733-1 http://dx.doi.org/10.1016/0378-1119(94)90733-1 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1998.00716.x http://dx.doi.org/10.1046/j.1365-2958.1998.00716.x DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1271/bbb.64.1203 http://dx.doi.org/10.1271/bbb.64.1203 EC_number EC:2.7.13.3 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.13.3 EMBL AF201840 http://www.ebi.ac.uk/ena/data/view/AF201840 EMBL AF201841 http://www.ebi.ac.uk/ena/data/view/AF201841 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D14008 http://www.ebi.ac.uk/ena/data/view/D14008 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.13.3 http://enzyme.expasy.org/EC/2.7.13.3 EchoBASE EB1567 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1567 EcoGene EG11610 http://www.ecogene.org/geneInfo.php?eg_id=EG11610 EnsemblBacteria AAC75429 http://www.ensemblgenomes.org/id/AAC75429 EnsemblBacteria AAC75429 http://www.ensemblgenomes.org/id/AAC75429 EnsemblBacteria BAA16241 http://www.ensemblgenomes.org/id/BAA16241 EnsemblBacteria BAA16241 http://www.ensemblgenomes.org/id/BAA16241 EnsemblBacteria BAA16241 http://www.ensemblgenomes.org/id/BAA16241 EnsemblBacteria b2370 http://www.ensemblgenomes.org/id/b2370 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0000155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000155 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0009927 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009927 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0010447 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010447 GO_process GO:0046777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046777 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.10.287.130 http://www.cathdb.info/version/latest/superfamily/1.10.287.130 Gene3D 1.20.120.160 http://www.cathdb.info/version/latest/superfamily/1.20.120.160 Gene3D 3.30.565.10 http://www.cathdb.info/version/latest/superfamily/3.30.565.10 GeneID 946844 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946844 HOGENOM HOG000122879 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122879&db=HOGENOM6 InParanoid P30855 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30855 IntAct P30855 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P30855* IntEnz 2.7.13.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.13.3 InterPro IPR001638 http://www.ebi.ac.uk/interpro/entry/IPR001638 InterPro IPR001789 http://www.ebi.ac.uk/interpro/entry/IPR001789 InterPro IPR003594 http://www.ebi.ac.uk/interpro/entry/IPR003594 InterPro IPR003661 http://www.ebi.ac.uk/interpro/entry/IPR003661 InterPro IPR004358 http://www.ebi.ac.uk/interpro/entry/IPR004358 InterPro IPR005467 http://www.ebi.ac.uk/interpro/entry/IPR005467 InterPro IPR008207 http://www.ebi.ac.uk/interpro/entry/IPR008207 InterPro IPR011006 http://www.ebi.ac.uk/interpro/entry/IPR011006 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01001 http://www.genome.jp/dbget-bin/www_bget?ko01001 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW2367 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2367 KEGG_Gene eco:b2370 http://www.genome.jp/dbget-bin/www_bget?eco:b2370 KEGG_Orthology KO:K07679 http://www.genome.jp/dbget-bin/www_bget?KO:K07679 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 KEGG_Pathway ko05133 http://www.genome.jp/kegg-bin/show_pathway?ko05133 MINT MINT-1288120 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1288120 OMA DHAVYIC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DHAVYIC PRINTS PR00344 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00344 PROSITE PS50109 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50109 PROSITE PS50110 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50110 PROSITE PS50894 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50894 PSORT swissprot:EVGS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EVGS_ECOLI PSORT-B swissprot:EVGS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EVGS_ECOLI PSORT2 swissprot:EVGS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EVGS_ECOLI Pfam PF00072 http://pfam.xfam.org/family/PF00072 Pfam PF00497 http://pfam.xfam.org/family/PF00497 Pfam PF00512 http://pfam.xfam.org/family/PF00512 Pfam PF01627 http://pfam.xfam.org/family/PF01627 Pfam PF02518 http://pfam.xfam.org/family/PF02518 Phobius swissprot:EVGS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EVGS_ECOLI PhylomeDB P30855 http://phylomedb.org/?seqid=P30855 ProteinModelPortal P30855 http://www.proteinmodelportal.org/query/uniprot/P30855 PubMed 10923791 http://www.ncbi.nlm.nih.gov/pubmed/10923791 PubMed 1289796 http://www.ncbi.nlm.nih.gov/pubmed/1289796 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8125343 http://www.ncbi.nlm.nih.gov/pubmed/8125343 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9535079 http://www.ncbi.nlm.nih.gov/pubmed/9535079 RefSeq NP_416871 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416871 SMART SM00062 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00062 SMART SM00073 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00073 SMART SM00387 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00387 SMART SM00388 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00388 SMART SM00448 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00448 SMR P30855 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P30855 STRING 511145.b2370 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2370&targetmode=cogs SUPFAM SSF47226 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47226 SUPFAM SSF47384 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47384 SUPFAM SSF52172 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52172 SUPFAM SSF55874 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55874 UniProtKB EVGS_ECOLI http://www.uniprot.org/uniprot/EVGS_ECOLI UniProtKB-AC P30855 http://www.uniprot.org/uniprot/P30855 charge swissprot:EVGS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EVGS_ECOLI eggNOG COG0784 http://eggnogapi.embl.de/nog_data/html/tree/COG0784 eggNOG COG0834 http://eggnogapi.embl.de/nog_data/html/tree/COG0834 eggNOG COG2198 http://eggnogapi.embl.de/nog_data/html/tree/COG2198 eggNOG ENOG4105BZU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZU epestfind swissprot:EVGS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EVGS_ECOLI garnier swissprot:EVGS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EVGS_ECOLI helixturnhelix swissprot:EVGS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EVGS_ECOLI hmoment swissprot:EVGS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EVGS_ECOLI iep swissprot:EVGS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EVGS_ECOLI inforesidue swissprot:EVGS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EVGS_ECOLI octanol swissprot:EVGS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EVGS_ECOLI pepcoil swissprot:EVGS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EVGS_ECOLI pepdigest swissprot:EVGS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EVGS_ECOLI pepinfo swissprot:EVGS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EVGS_ECOLI pepnet swissprot:EVGS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EVGS_ECOLI pepstats swissprot:EVGS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EVGS_ECOLI pepwheel swissprot:EVGS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EVGS_ECOLI pepwindow swissprot:EVGS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EVGS_ECOLI sigcleave swissprot:EVGS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EVGS_ECOLI ## Database ID URL or Descriptions # BioGrid 4260828 116 # EcoGene EG10054 araC # FUNCTION ARAC_ECOLI This protein controls the expression of at least six genes that are involved in the transport and catabolism of L- arabinose. It regulates initiation of transcription of the araBAD operon and it also controls its own synthesis. The L-arabinose operon displays both positive and negative regulation through AraC. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000987 core promoter proximal region sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IBA:GO_Central. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IBA:GO_Central. # GO_process GO:0019568 arabinose catabolic process; IMP:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.10.60 -; 2. # Gene3D 2.60.120.280 -; 1. # INTERACTION ARAC_ECOLI P0A8P6 xerC; NbExp=3; IntAct=EBI-1113479, EBI-1133806; # IntAct P0A9E0 12 # InterPro IPR003313 AraC-bd # InterPro IPR009057 Homeodomain-like # InterPro IPR018060 HTH_AraC # InterPro IPR018062 HTH_AraC-typ_CS # InterPro IPR020449 Tscrpt_reg_HTH_AraC-type # KEGG_Brite ko03000 Transcription factors # Organism ARAC_ECOLI Escherichia coli (strain K12) # PATRIC 32115229 VBIEscCol129921_0066 # PDB 1XJA X-ray; 2.40 A; A/B/C/D/E=1-178 # PDB 2AAC X-ray; 1.60 A; A/B=2-178 # PDB 2ARA X-ray; 2.80 A; A=19-167 # PDB 2ARC X-ray; 1.50 A; A/B=7-170 # PDB 2K9S NMR; -; A=175-281 # PIR A91473 RGECA # PRINTS PR00032 HTHARAC # PROSITE PS00041 HTH_ARAC_FAMILY_1 # PROSITE PS01124 HTH_ARAC_FAMILY_2 # Pfam PF02311 AraC_binding # Pfam PF12833 HTH_18 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ARAC_ECOLI Arabinose operon regulatory protein # RefSeq NP_414606 NC_000913.3 # RefSeq WP_001300811 NZ_LN832404.1 # SIMILARITY Contains 1 HTH araC/xylS-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00593}. # SMART SM00342 HTH_ARAC # SUBCELLULAR LOCATION ARAC_ECOLI Cytoplasm. # SUBUNIT ARAC_ECOLI Homodimer. # SUPFAM SSF46689 SSF46689; 2 # SUPFAM SSF51215 SSF51215 # eggNOG ENOG41063TF Bacteria # eggNOG ENOG4111G16 LUCA BLAST swissprot:ARAC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARAC_ECOLI BioCyc ECOL316407:JW0063-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0063-MONOMER BioCyc EcoCyc:PD00242 http://biocyc.org/getid?id=EcoCyc:PD00242 COG COG2207 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2207 DIP DIP-9125N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9125N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/jmbi.1997.1314 http://dx.doi.org/10.1006/jmbi.1997.1314 DOI 10.1007/BF00267373 http://dx.doi.org/10.1007/BF00267373 DOI 10.1016/0378-1119(80)90100-6 http://dx.doi.org/10.1016/0378-1119(80)90100-6 DOI 10.1016/S0022-2836(82)80020-X http://dx.doi.org/10.1016/S0022-2836(82)80020-X DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1093/nar/8.22.5267 http://dx.doi.org/10.1093/nar/8.22.5267 DOI 10.1126/science.276.5311.421 http://dx.doi.org/10.1126/science.276.5311.421 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01641 http://www.ebi.ac.uk/ena/data/view/J01641 EMBL K01303 http://www.ebi.ac.uk/ena/data/view/K01303 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00256 http://www.ebi.ac.uk/ena/data/view/V00256 EMBL V00259 http://www.ebi.ac.uk/ena/data/view/V00259 EchoBASE EB0052 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0052 EcoGene EG10054 http://www.ecogene.org/geneInfo.php?eg_id=EG10054 EnsemblBacteria AAC73175 http://www.ensemblgenomes.org/id/AAC73175 EnsemblBacteria AAC73175 http://www.ensemblgenomes.org/id/AAC73175 EnsemblBacteria BAB96633 http://www.ensemblgenomes.org/id/BAB96633 EnsemblBacteria BAB96633 http://www.ensemblgenomes.org/id/BAB96633 EnsemblBacteria BAB96633 http://www.ensemblgenomes.org/id/BAB96633 EnsemblBacteria b0064 http://www.ensemblgenomes.org/id/b0064 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000987 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000987 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0019568 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019568 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 Gene3D 2.60.120.280 http://www.cathdb.info/version/latest/superfamily/2.60.120.280 GeneID 944780 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944780 HOGENOM HOG000276603 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276603&db=HOGENOM6 InParanoid P0A9E0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9E0 IntAct P0A9E0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9E0* InterPro IPR003313 http://www.ebi.ac.uk/interpro/entry/IPR003313 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR018060 http://www.ebi.ac.uk/interpro/entry/IPR018060 InterPro IPR018062 http://www.ebi.ac.uk/interpro/entry/IPR018062 InterPro IPR020449 http://www.ebi.ac.uk/interpro/entry/IPR020449 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW0063 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0063 KEGG_Gene eco:b0064 http://www.genome.jp/dbget-bin/www_bget?eco:b0064 KEGG_Orthology KO:K02099 http://www.genome.jp/dbget-bin/www_bget?KO:K02099 OMA GFEDQLY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GFEDQLY PDB 1XJA http://www.ebi.ac.uk/pdbe-srv/view/entry/1XJA PDB 2AAC http://www.ebi.ac.uk/pdbe-srv/view/entry/2AAC PDB 2ARA http://www.ebi.ac.uk/pdbe-srv/view/entry/2ARA PDB 2ARC http://www.ebi.ac.uk/pdbe-srv/view/entry/2ARC PDB 2K9S http://www.ebi.ac.uk/pdbe-srv/view/entry/2K9S PDBsum 1XJA http://www.ebi.ac.uk/pdbsum/1XJA PDBsum 2AAC http://www.ebi.ac.uk/pdbsum/2AAC PDBsum 2ARA http://www.ebi.ac.uk/pdbsum/2ARA PDBsum 2ARC http://www.ebi.ac.uk/pdbsum/2ARC PDBsum 2K9S http://www.ebi.ac.uk/pdbsum/2K9S PRINTS PR00032 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00032 PROSITE PS00041 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00041 PROSITE PS01124 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01124 PSORT swissprot:ARAC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARAC_ECOLI PSORT-B swissprot:ARAC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARAC_ECOLI PSORT2 swissprot:ARAC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARAC_ECOLI Pfam PF02311 http://pfam.xfam.org/family/PF02311 Pfam PF12833 http://pfam.xfam.org/family/PF12833 Phobius swissprot:ARAC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARAC_ECOLI PhylomeDB P0A9E0 http://phylomedb.org/?seqid=P0A9E0 ProteinModelPortal P0A9E0 http://www.proteinmodelportal.org/query/uniprot/P0A9E0 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6160371 http://www.ncbi.nlm.nih.gov/pubmed/6160371 PubMed 6283093 http://www.ncbi.nlm.nih.gov/pubmed/6283093 PubMed 7008027 http://www.ncbi.nlm.nih.gov/pubmed/7008027 PubMed 7019009 http://www.ncbi.nlm.nih.gov/pubmed/7019009 PubMed 9103202 http://www.ncbi.nlm.nih.gov/pubmed/9103202 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9367758 http://www.ncbi.nlm.nih.gov/pubmed/9367758 RefSeq NP_414606 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414606 RefSeq WP_001300811 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300811 SMART SM00342 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00342 SMR P0A9E0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9E0 STRING 511145.b0064 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0064&targetmode=cogs STRING COG2207 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2207&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF51215 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51215 UniProtKB ARAC_ECOLI http://www.uniprot.org/uniprot/ARAC_ECOLI UniProtKB-AC P0A9E0 http://www.uniprot.org/uniprot/P0A9E0 charge swissprot:ARAC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARAC_ECOLI eggNOG ENOG41063TF http://eggnogapi.embl.de/nog_data/html/tree/ENOG41063TF eggNOG ENOG4111G16 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111G16 epestfind swissprot:ARAC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARAC_ECOLI garnier swissprot:ARAC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARAC_ECOLI helixturnhelix swissprot:ARAC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARAC_ECOLI hmoment swissprot:ARAC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARAC_ECOLI iep swissprot:ARAC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARAC_ECOLI inforesidue swissprot:ARAC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARAC_ECOLI octanol swissprot:ARAC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARAC_ECOLI pepcoil swissprot:ARAC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARAC_ECOLI pepdigest swissprot:ARAC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARAC_ECOLI pepinfo swissprot:ARAC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARAC_ECOLI pepnet swissprot:ARAC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARAC_ECOLI pepstats swissprot:ARAC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARAC_ECOLI pepwheel swissprot:ARAC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARAC_ECOLI pepwindow swissprot:ARAC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARAC_ECOLI sigcleave swissprot:ARAC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARAC_ECOLI ## Database ID URL or Descriptions # BioGrid 4263276 97 # DISRUPTION PHENOTYPE LGT_ECOLI Mutants are defective in diacylglyceryl modification of prolipoprotein. {ECO 0000269|PubMed 22287519, ECO 0000269|PubMed 7896715}. # EcoGene EG12128 lgt # FUNCTION LGT_ECOLI Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins. {ECO 0000269|PubMed 8051048}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IDA:EcoCyc. # GO_function GO:0008961 phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity; IDA:EcoCyc. # GO_process GO:0009249 protein lipoylation; IEA:InterPro. # GO_process GO:0042158 lipoprotein biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0009058 biosynthetic process # HAMAP MF_01147 Lgt # InterPro IPR001640 Prolipoprot_diAcglycer_Trfase # KEGG_Brite ko01000 Enzymes # Organism LGT_ECOLI Escherichia coli (strain K12) # PATHWAY LGT_ECOLI Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer). {ECO 0000269|PubMed 7896715, ECO 0000269|PubMed 8051048}. # PATRIC 32121074 VBIEscCol129921_2926 # PDB 5AZB X-ray; 1.60 A; A=2-291 # PDB 5AZC X-ray; 1.90 A; A=2-291 # PIR A56149 A56149 # PROSITE PS01311 LGT # Pfam PF01790 LGT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LGT_ECOLI Prolipoprotein diacylglyceryl transferase # RefSeq NP_417305 NC_000913.3 # RefSeq WP_000204658 NZ_LN832404.1 # SIMILARITY Belongs to the Lgt family. {ECO 0000305}. # SUBCELLULAR LOCATION LGT_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 22287519}; Multi- pass membrane protein {ECO 0000269|PubMed 22287519}. # TIGRFAMs TIGR00544 lgt # eggNOG COG0682 LUCA # eggNOG ENOG4105C3B Bacteria BLAST swissprot:LGT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LGT_ECOLI BioCyc ECOL316407:JW2796-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2796-MONOMER BioCyc EcoCyc:EG12128-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12128-MONOMER BioCyc MetaCyc:EG12128-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12128-MONOMER COG COG0682 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0682 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.80.16.4914 http://dx.doi.org/10.1073/pnas.80.16.4914 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.06641-11 http://dx.doi.org/10.1128/JB.06641-11 EC_number EC:2.4.99.- http://www.genome.jp/dbget-bin/www_bget?EC:2.4.99.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01710 http://www.ebi.ac.uk/ena/data/view/J01710 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U12289 http://www.ebi.ac.uk/ena/data/view/U12289 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 ENZYME 2.4.99.- http://enzyme.expasy.org/EC/2.4.99.- EchoBASE EB2049 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2049 EcoGene EG12128 http://www.ecogene.org/geneInfo.php?eg_id=EG12128 EnsemblBacteria AAC75867 http://www.ensemblgenomes.org/id/AAC75867 EnsemblBacteria AAC75867 http://www.ensemblgenomes.org/id/AAC75867 EnsemblBacteria BAE76897 http://www.ensemblgenomes.org/id/BAE76897 EnsemblBacteria BAE76897 http://www.ensemblgenomes.org/id/BAE76897 EnsemblBacteria BAE76897 http://www.ensemblgenomes.org/id/BAE76897 EnsemblBacteria b2828 http://www.ensemblgenomes.org/id/b2828 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008961 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008961 GO_process GO:0009249 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009249 GO_process GO:0042158 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042158 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 947303 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947303 HAMAP MF_01147 http://hamap.expasy.org/unirule/MF_01147 HOGENOM HOG000098666 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000098666&db=HOGENOM6 InParanoid P60955 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P60955 IntEnz 2.4.99 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.99 InterPro IPR001640 http://www.ebi.ac.uk/interpro/entry/IPR001640 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2796 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2796 KEGG_Gene eco:b2828 http://www.genome.jp/dbget-bin/www_bget?eco:b2828 KEGG_Orthology KO:K13292 http://www.genome.jp/dbget-bin/www_bget?KO:K13292 OMA AHRTKRH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AHRTKRH PDB 5AZB http://www.ebi.ac.uk/pdbe-srv/view/entry/5AZB PDB 5AZC http://www.ebi.ac.uk/pdbe-srv/view/entry/5AZC PDBsum 5AZB http://www.ebi.ac.uk/pdbsum/5AZB PDBsum 5AZC http://www.ebi.ac.uk/pdbsum/5AZC PROSITE PS01311 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01311 PSORT swissprot:LGT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LGT_ECOLI PSORT-B swissprot:LGT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LGT_ECOLI PSORT2 swissprot:LGT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LGT_ECOLI Pfam PF01790 http://pfam.xfam.org/family/PF01790 Phobius swissprot:LGT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LGT_ECOLI PhylomeDB P60955 http://phylomedb.org/?seqid=P60955 ProteinModelPortal P60955 http://www.proteinmodelportal.org/query/uniprot/P60955 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22287519 http://www.ncbi.nlm.nih.gov/pubmed/22287519 PubMed 6308660 http://www.ncbi.nlm.nih.gov/pubmed/6308660 PubMed 7592473 http://www.ncbi.nlm.nih.gov/pubmed/7592473 PubMed 7896715 http://www.ncbi.nlm.nih.gov/pubmed/7896715 PubMed 8051048 http://www.ncbi.nlm.nih.gov/pubmed/8051048 PubMed 9139912 http://www.ncbi.nlm.nih.gov/pubmed/9139912 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417305 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417305 RefSeq WP_000204658 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000204658 SMR P60955 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P60955 STRING 511145.b2828 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2828&targetmode=cogs STRING COG0682 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0682&targetmode=cogs TIGRFAMs TIGR00544 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00544 UniProtKB LGT_ECOLI http://www.uniprot.org/uniprot/LGT_ECOLI UniProtKB-AC P60955 http://www.uniprot.org/uniprot/P60955 charge swissprot:LGT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LGT_ECOLI eggNOG COG0682 http://eggnogapi.embl.de/nog_data/html/tree/COG0682 eggNOG ENOG4105C3B http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C3B epestfind swissprot:LGT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LGT_ECOLI garnier swissprot:LGT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LGT_ECOLI helixturnhelix swissprot:LGT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LGT_ECOLI hmoment swissprot:LGT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LGT_ECOLI iep swissprot:LGT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LGT_ECOLI inforesidue swissprot:LGT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LGT_ECOLI octanol swissprot:LGT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LGT_ECOLI pepcoil swissprot:LGT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LGT_ECOLI pepdigest swissprot:LGT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LGT_ECOLI pepinfo swissprot:LGT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LGT_ECOLI pepnet swissprot:LGT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LGT_ECOLI pepstats swissprot:LGT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LGT_ECOLI pepwheel swissprot:LGT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LGT_ECOLI pepwindow swissprot:LGT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LGT_ECOLI sigcleave swissprot:LGT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LGT_ECOLI ## Database ID URL or Descriptions # AltName FLGB_ECOLI Putative proximal rod protein # BioGrid 4261281 15 # DISRUPTION PHENOTYPE Strongly repressed swarming and swimming. {ECO:0000269|PubMed 17122336}. # EcoGene EG14266 flgB # FUNCTION FLGB_ECOLI Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity). {ECO 0000250}. # GO_component GO:0009424 bacterial-type flagellum hook; IBA:GO_Central. # GO_component GO:0030694 bacterial-type flagellum basal body, rod; IEA:InterPro. # GO_process GO:0071978 bacterial-type flagellum-dependent swarming motility; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0048870 cell motility # IntAct P0ABW9 6 # InterPro IPR001444 Flag_bb_rod_N # InterPro IPR006300 FlgB # InterPro IPR019776 Flagellar_basal_body_rod_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Pathway ko02040 Flagellar assembly # Organism FLGB_ECOLI Escherichia coli (strain K12) # PATRIC 32117387 VBIEscCol129921_1116 # PIR F64850 F64850 # PIRSF PIRSF002889 Rod_FlgB # PROSITE PS00588 FLAGELLA_BB_ROD # Pfam PF00460 Flg_bb_rod # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FLGB_ECOLI Flagellar basal body rod protein FlgB # RefSeq NP_415591 NC_000913.3 # RefSeq WP_000884702 NZ_LN832404.1 # SIMILARITY Belongs to the flagella basal body rod proteins family. {ECO 0000305}. # SUBCELLULAR LOCATION FLGB_ECOLI Bacterial flagellum basal body {ECO 0000250}. # SUBUNIT The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod. In Gram-negative bacteria, at least four rings, L, P, S and M are present, whereas Gram-positive bacteria lack the L and P rings. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF build up the proximal portion of the rod with about 6 subunits each. Rod assembly occurs by export via the flagellum-specific pathway of its constituent proteins and by their incorporation into the rod structure in the probable order of FlgB, FlgC, FlgF and FlgG. Another protein, FliE, also assembles onto the stable rod structure (By similarity). {ECO 0000250}. # TIGRFAMs TIGR01396 FlgB # eggNOG COG1815 LUCA # eggNOG ENOG4105K88 Bacteria BLAST swissprot:FLGB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLGB_ECOLI BioCyc ECOL316407:JW1060-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1060-MONOMER BioCyc EcoCyc:FLGB-FLAGELLAR-MOTOR-ROD-PROTEIN http://biocyc.org/getid?id=EcoCyc:FLGB-FLAGELLAR-MOTOR-ROD-PROTEIN COG COG1815 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1815 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01294-06 http://dx.doi.org/10.1128/JB.01294-06 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4014 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4014 EcoGene EG14266 http://www.ecogene.org/geneInfo.php?eg_id=EG14266 EnsemblBacteria AAC74157 http://www.ensemblgenomes.org/id/AAC74157 EnsemblBacteria AAC74157 http://www.ensemblgenomes.org/id/AAC74157 EnsemblBacteria BAA35881 http://www.ensemblgenomes.org/id/BAA35881 EnsemblBacteria BAA35881 http://www.ensemblgenomes.org/id/BAA35881 EnsemblBacteria BAA35881 http://www.ensemblgenomes.org/id/BAA35881 EnsemblBacteria b1073 http://www.ensemblgenomes.org/id/b1073 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009424 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009424 GO_component GO:0030694 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030694 GO_process GO:0071978 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071978 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 GeneID 945678 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945678 HOGENOM HOG000257191 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000257191&db=HOGENOM6 InParanoid P0ABW9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABW9 IntAct P0ABW9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABW9* InterPro IPR001444 http://www.ebi.ac.uk/interpro/entry/IPR001444 InterPro IPR006300 http://www.ebi.ac.uk/interpro/entry/IPR006300 InterPro IPR019776 http://www.ebi.ac.uk/interpro/entry/IPR019776 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW1060 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1060 KEGG_Gene eco:b1073 http://www.genome.jp/dbget-bin/www_bget?eco:b1073 KEGG_Orthology KO:K02387 http://www.genome.jp/dbget-bin/www_bget?KO:K02387 KEGG_Pathway ko02040 http://www.genome.jp/kegg-bin/show_pathway?ko02040 OMA YRIPTQP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YRIPTQP PROSITE PS00588 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00588 PSORT swissprot:FLGB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLGB_ECOLI PSORT-B swissprot:FLGB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLGB_ECOLI PSORT2 swissprot:FLGB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLGB_ECOLI Pfam PF00460 http://pfam.xfam.org/family/PF00460 Phobius swissprot:FLGB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLGB_ECOLI PhylomeDB P0ABW9 http://phylomedb.org/?seqid=P0ABW9 ProteinModelPortal P0ABW9 http://www.proteinmodelportal.org/query/uniprot/P0ABW9 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17122336 http://www.ncbi.nlm.nih.gov/pubmed/17122336 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415591 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415591 RefSeq WP_000884702 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000884702 SMR P0ABW9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABW9 STRING 511145.b1073 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1073&targetmode=cogs STRING COG1815 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1815&targetmode=cogs TIGRFAMs TIGR01396 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01396 UniProtKB FLGB_ECOLI http://www.uniprot.org/uniprot/FLGB_ECOLI UniProtKB-AC P0ABW9 http://www.uniprot.org/uniprot/P0ABW9 charge swissprot:FLGB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLGB_ECOLI eggNOG COG1815 http://eggnogapi.embl.de/nog_data/html/tree/COG1815 eggNOG ENOG4105K88 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K88 epestfind swissprot:FLGB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLGB_ECOLI garnier swissprot:FLGB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLGB_ECOLI helixturnhelix swissprot:FLGB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLGB_ECOLI hmoment swissprot:FLGB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLGB_ECOLI iep swissprot:FLGB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLGB_ECOLI inforesidue swissprot:FLGB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLGB_ECOLI octanol swissprot:FLGB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLGB_ECOLI pepcoil swissprot:FLGB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLGB_ECOLI pepdigest swissprot:FLGB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLGB_ECOLI pepinfo swissprot:FLGB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLGB_ECOLI pepnet swissprot:FLGB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLGB_ECOLI pepstats swissprot:FLGB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLGB_ECOLI pepwheel swissprot:FLGB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLGB_ECOLI pepwindow swissprot:FLGB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLGB_ECOLI sigcleave swissprot:FLGB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLGB_ECOLI ## Database ID URL or Descriptions # AltName MUKF_ECOLI Protein KicB # BioGrid 4260007 248 # CAUTION Was originally thought to be a killing factor. PubMed:8602138 showed that it is not involved in killing system. {ECO 0000305}. # EcoGene EG12165 mukF # FUNCTION MUKF_ECOLI Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity. {ECO 0000269|PubMed 8602138}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-HAMAP. # GO_component GO:0009295 nucleoid; IEA:UniProtKB-SubCell. # GO_function GO:0005509 calcium ion binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006260 DNA replication; IEA:UniProtKB-HAMAP. # GO_process GO:0007049 cell cycle; IEA:UniProtKB-KW. # GO_process GO:0007059 chromosome segregation; IEA:UniProtKB-HAMAP. # GO_process GO:0030261 chromosome condensation; IEA:UniProtKB-KW. # GO_process GO:0051301 cell division; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0007049 cell cycle # GOslim_process GO:0007059 chromosome segregation # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0051276 chromosome organization # GOslim_process GO:0051301 cell division # Gene3D 1.10.10.10 -; 1. # HAMAP MF_01803 MukF # INTERACTION MUKF_ECOLI P22524 mukE; NbExp=4; IntAct=EBI-554679, EBI-554672; # IntAct P60293 3 # InterPro IPR005582 Chromosome_partition_MukF # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR033439 MukF_WHTH # InterPro IPR033440 MukF_M # InterPro IPR033441 MukF_C # KEGG_Brite ko03036 Chromosome # Organism MUKF_ECOLI Escherichia coli (strain K12) # PATRIC 32117057 VBIEscCol129921_0953 # PDB 1T98 X-ray; 2.90 A; A/B=1-287 # PDB 3EUH X-ray; 2.90 A; A/B=1-440 # PDB 3RPU X-ray; 3.60 A; A/B/X=1-440 # PIR S43911 S43911 # PIRSF PIRSF018282 MukF # Pfam PF03882 KicB # Pfam PF17192 MukF_M # Pfam PF17193 MukF_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MUKF_ECOLI Chromosome partition protein MukF # RefSeq NP_415442 NC_000913.3 # RefSeq WP_001288850 NZ_LN832404.1 # SIMILARITY Belongs to the MukF family. {ECO 0000305}. # SUBCELLULAR LOCATION MUKF_ECOLI Cytoplasm, nucleoid. Note=Restricted to the nucleoid region. # SUBUNIT MUKF_ECOLI Interacts, and probably forms a ternary complex, with MukE and MukB via its C-terminal region. The complex formation is stimulated by calcium or magnesium. It is required for an interaction between MukE and MukB. {ECO 0000269|PubMed 10545099, ECO 0000269|PubMed 20921377}. # SUPFAM SSF140570 SSF140570 # SUPFAM SSF46785 SSF46785 # eggNOG COG3006 LUCA # eggNOG ENOG4105GHU Bacteria BLAST swissprot:MUKF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MUKF_ECOLI BioCyc ECOL316407:JW0905-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0905-MONOMER BioCyc EcoCyc:EG12165-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12165-MONOMER COG COG3006 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3006 DIP DIP-39981N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-39981N DOI 10.1007/BF02174381 http://dx.doi.org/10.1007/BF02174381 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.1008678107 http://dx.doi.org/10.1073/pnas.1008678107 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/emboj/18.21.5873 http://dx.doi.org/10.1093/emboj/18.21.5873 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D26440 http://www.ebi.ac.uk/ena/data/view/D26440 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2084 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2084 EcoGene EG12165 http://www.ecogene.org/geneInfo.php?eg_id=EG12165 EnsemblBacteria AAC74008 http://www.ensemblgenomes.org/id/AAC74008 EnsemblBacteria AAC74008 http://www.ensemblgenomes.org/id/AAC74008 EnsemblBacteria BAA35668 http://www.ensemblgenomes.org/id/BAA35668 EnsemblBacteria BAA35668 http://www.ensemblgenomes.org/id/BAA35668 EnsemblBacteria BAA35668 http://www.ensemblgenomes.org/id/BAA35668 EnsemblBacteria b0922 http://www.ensemblgenomes.org/id/b0922 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0009295 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009295 GO_function GO:0005509 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509 GO_process GO:0006260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260 GO_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GO_process GO:0007059 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007059 GO_process GO:0030261 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030261 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GOslim_process GO:0007059 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007059 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0051276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051276 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 945548 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945548 HAMAP MF_01803 http://hamap.expasy.org/unirule/MF_01803 HOGENOM HOG000278265 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278265&db=HOGENOM6 IntAct P60293 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P60293* InterPro IPR005582 http://www.ebi.ac.uk/interpro/entry/IPR005582 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR033439 http://www.ebi.ac.uk/interpro/entry/IPR033439 InterPro IPR033440 http://www.ebi.ac.uk/interpro/entry/IPR033440 InterPro IPR033441 http://www.ebi.ac.uk/interpro/entry/IPR033441 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene ecj:JW0905 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0905 KEGG_Gene eco:b0922 http://www.genome.jp/dbget-bin/www_bget?eco:b0922 KEGG_Orthology KO:K03633 http://www.genome.jp/dbget-bin/www_bget?KO:K03633 MINT MINT-1300138 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1300138 OMA NRVFSQR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NRVFSQR PDB 1T98 http://www.ebi.ac.uk/pdbe-srv/view/entry/1T98 PDB 3EUH http://www.ebi.ac.uk/pdbe-srv/view/entry/3EUH PDB 3RPU http://www.ebi.ac.uk/pdbe-srv/view/entry/3RPU PDBsum 1T98 http://www.ebi.ac.uk/pdbsum/1T98 PDBsum 3EUH http://www.ebi.ac.uk/pdbsum/3EUH PDBsum 3RPU http://www.ebi.ac.uk/pdbsum/3RPU PSORT swissprot:MUKF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MUKF_ECOLI PSORT-B swissprot:MUKF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MUKF_ECOLI PSORT2 swissprot:MUKF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MUKF_ECOLI Pfam PF03882 http://pfam.xfam.org/family/PF03882 Pfam PF17192 http://pfam.xfam.org/family/PF17192 Pfam PF17193 http://pfam.xfam.org/family/PF17193 Phobius swissprot:MUKF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MUKF_ECOLI ProteinModelPortal P60293 http://www.proteinmodelportal.org/query/uniprot/P60293 PubMed 10545099 http://www.ncbi.nlm.nih.gov/pubmed/10545099 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20921377 http://www.ncbi.nlm.nih.gov/pubmed/20921377 PubMed 7513784 http://www.ncbi.nlm.nih.gov/pubmed/7513784 PubMed 8602138 http://www.ncbi.nlm.nih.gov/pubmed/8602138 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415442 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415442 RefSeq WP_001288850 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001288850 SMR P60293 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P60293 STRING 511145.b0922 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0922&targetmode=cogs STRING COG3006 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3006&targetmode=cogs SUPFAM SSF140570 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF140570 SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB MUKF_ECOLI http://www.uniprot.org/uniprot/MUKF_ECOLI UniProtKB-AC P60293 http://www.uniprot.org/uniprot/P60293 charge swissprot:MUKF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MUKF_ECOLI eggNOG COG3006 http://eggnogapi.embl.de/nog_data/html/tree/COG3006 eggNOG ENOG4105GHU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105GHU epestfind swissprot:MUKF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MUKF_ECOLI garnier swissprot:MUKF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MUKF_ECOLI helixturnhelix swissprot:MUKF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MUKF_ECOLI hmoment swissprot:MUKF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MUKF_ECOLI iep swissprot:MUKF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MUKF_ECOLI inforesidue swissprot:MUKF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MUKF_ECOLI octanol swissprot:MUKF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MUKF_ECOLI pepcoil swissprot:MUKF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MUKF_ECOLI pepdigest swissprot:MUKF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MUKF_ECOLI pepinfo swissprot:MUKF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MUKF_ECOLI pepnet swissprot:MUKF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MUKF_ECOLI pepstats swissprot:MUKF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MUKF_ECOLI pepwheel swissprot:MUKF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MUKF_ECOLI pepwindow swissprot:MUKF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MUKF_ECOLI sigcleave swissprot:MUKF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MUKF_ECOLI ## Database ID URL or Descriptions # BioGrid 4262841 8 # EcoGene EG12194 cbpM # FUNCTION CBPM_ECOLI Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ. # GO_function GO:0004857 enzyme inhibitor activity; IDA:EcoCyc. # GOslim_function GO:0030234 enzyme regulator activity # HAMAP MF_01155 CbpM # INDUCTION CBPM_ECOLI In late stationary phase. # InterPro IPR022835 CbpM # Organism CBPM_ECOLI Escherichia coli (strain K12) # PATRIC 32117223 VBIEscCol129921_1035 # PIR E64841 E64841 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Chaperone modulatory protein CbpM {ECO:0000255|HAMAP-Rule MF_01155} # RefSeq NP_415519 NC_000913.3 # RefSeq WP_000024560 NZ_LN832404.1 # SIMILARITY Belongs to the CbpM family. {ECO:0000255|HAMAP- Rule MF_01155}. # eggNOG ENOG4108ZKH Bacteria # eggNOG ENOG411205W LUCA BLAST swissprot:CBPM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CBPM_ECOLI BioCyc ECOL316407:JW0984-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0984-MONOMER BioCyc EcoCyc:EG12194-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12194-MONOMER DIP DIP-47830N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47830N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.91.3.1054 http://dx.doi.org/10.1073/pnas.91.3.1054 DOI 10.1074/jbc.M404862200 http://dx.doi.org/10.1074/jbc.M404862200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01757-06 http://dx.doi.org/10.1128/JB.01757-06 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D16500 http://www.ebi.ac.uk/ena/data/view/D16500 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2111 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2111 EcoGene EG12194 http://www.ecogene.org/geneInfo.php?eg_id=EG12194 EnsemblBacteria AAC74084 http://www.ensemblgenomes.org/id/AAC74084 EnsemblBacteria AAC74084 http://www.ensemblgenomes.org/id/AAC74084 EnsemblBacteria BAA36141 http://www.ensemblgenomes.org/id/BAA36141 EnsemblBacteria BAA36141 http://www.ensemblgenomes.org/id/BAA36141 EnsemblBacteria BAA36141 http://www.ensemblgenomes.org/id/BAA36141 EnsemblBacteria b0999 http://www.ensemblgenomes.org/id/b0999 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004857 GOslim_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 GeneID 945597 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945597 HAMAP MF_01155 http://hamap.expasy.org/unirule/MF_01155 HOGENOM HOG000219382 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219382&db=HOGENOM6 IntAct P63264 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P63264* InterPro IPR022835 http://www.ebi.ac.uk/interpro/entry/IPR022835 KEGG_Gene ecj:JW0984 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0984 KEGG_Gene eco:b0999 http://www.genome.jp/dbget-bin/www_bget?eco:b0999 OMA NSMLKQR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NSMLKQR PSORT swissprot:CBPM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CBPM_ECOLI PSORT-B swissprot:CBPM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CBPM_ECOLI PSORT2 swissprot:CBPM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CBPM_ECOLI Phobius swissprot:CBPM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CBPM_ECOLI ProteinModelPortal P63264 http://www.proteinmodelportal.org/query/uniprot/P63264 PubMed 15184371 http://www.ncbi.nlm.nih.gov/pubmed/15184371 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17337578 http://www.ncbi.nlm.nih.gov/pubmed/17337578 PubMed 8302830 http://www.ncbi.nlm.nih.gov/pubmed/8302830 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415519 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415519 RefSeq WP_000024560 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000024560 SMR P63264 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P63264 STRING 511145.b0999 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0999&targetmode=cogs UniProtKB CBPM_ECOLI http://www.uniprot.org/uniprot/CBPM_ECOLI UniProtKB-AC P63264 http://www.uniprot.org/uniprot/P63264 charge swissprot:CBPM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CBPM_ECOLI eggNOG ENOG4108ZKH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZKH eggNOG ENOG411205W http://eggnogapi.embl.de/nog_data/html/tree/ENOG411205W epestfind swissprot:CBPM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CBPM_ECOLI garnier swissprot:CBPM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CBPM_ECOLI helixturnhelix swissprot:CBPM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CBPM_ECOLI hmoment swissprot:CBPM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CBPM_ECOLI iep swissprot:CBPM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CBPM_ECOLI inforesidue swissprot:CBPM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CBPM_ECOLI octanol swissprot:CBPM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CBPM_ECOLI pepcoil swissprot:CBPM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CBPM_ECOLI pepdigest swissprot:CBPM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CBPM_ECOLI pepinfo swissprot:CBPM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CBPM_ECOLI pepnet swissprot:CBPM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CBPM_ECOLI pepstats swissprot:CBPM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CBPM_ECOLI pepwheel swissprot:CBPM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CBPM_ECOLI pepwindow swissprot:CBPM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CBPM_ECOLI sigcleave swissprot:CBPM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CBPM_ECOLI ## Database ID URL or Descriptions # BioGrid 4261356 236 # CATALYTIC ACTIVITY UDG_ECOLI UDP-glucose + 2 NAD(+) + H(2)O = UDP- glucuronate + 2 NADH. # EcoGene EG13407 ugd # GO_function GO:0003979 UDP-glucose 6-dehydrogenase activity; IDA:EcoCyc. # GO_function GO:0051287 NAD binding; IEA:InterPro. # GO_process GO:0006065 UDP-glucuronate biosynthetic process; IBA:GO_Central. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0009242 colanic acid biosynthetic process; IDA:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.1040.10 -; 1. # Gene3D 3.40.50.720 -; 2. # INTERACTION UDG_ECOLI P0A8F8 uvrB; NbExp=2; IntAct=EBI-1120497, EBI-552176; # IntAct P76373 4 # InterPro IPR001732 UDP-Glc/GDP-Man_DH_N # InterPro IPR008927 6-PGluconate_DH_C-like # InterPro IPR013328 6PGD_dom_2 # InterPro IPR014026 UDP-Glc/GDP-Man_DH_dimer # InterPro IPR014027 UDP-Glc/GDP-Man_DH_C # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR017476 UDP-Glc/GDP-Man # InterPro IPR028357 UDPglc_DH_bac # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00040 Pentose and glucuronate interconversions # KEGG_Pathway ko00053 Ascorbate and aldarate metabolism # KEGG_Pathway ko00500 Starch and sucrose metabolism # KEGG_Pathway ko00520 Amino sugar and nucleotide sugar metabolism # Organism UDG_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11374 PTHR11374 # PATHWAY Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose step 1/1. # PATHWAY UDG_ECOLI Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. # PATRIC 32119391 VBIEscCol129921_2105 # PIR C64968 C64968 # PIRSF PIRSF000124 UDPglc_GDPman_dh # PIRSF PIRSF500134 UDPglc_DH_bac # PTM UDG_ECOLI Phosphorylated on a tyrosine residue. It results in a significant increase of the dehydrogenase activity. {ECO 0000269|PubMed 12851388}. # Pfam PF00984 UDPG_MGDP_dh # Pfam PF03720 UDPG_MGDP_dh_C # Pfam PF03721 UDPG_MGDP_dh_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UDG_ECOLI UDP-glucose 6-dehydrogenase # RefSeq NP_416532 NC_000913.3 # RefSeq WP_000704857 NZ_LN832404.1 # SIMILARITY Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. {ECO 0000305}. # SMART SM00984 UDPG_MGDP_dh_C # SUPFAM SSF48179 SSF48179 # SUPFAM SSF51735 SSF51735 # SUPFAM SSF52413 SSF52413 # TIGRFAMs TIGR03026 NDP-sugDHase # UniPathway UPA00038 UER00491 # eggNOG COG1004 LUCA # eggNOG ENOG4105C6Y Bacteria BLAST swissprot:UDG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UDG_ECOLI BioCyc ECOL316407:JW2010-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2010-MONOMER BioCyc EcoCyc:UGD-MONOMER http://biocyc.org/getid?id=EcoCyc:UGD-MONOMER BioCyc MetaCyc:UGD-MONOMER http://biocyc.org/getid?id=MetaCyc:UGD-MONOMER COG COG1004 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1004 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M305134200 http://dx.doi.org/10.1074/jbc.M305134200 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.22 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.22 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.1.1.22 http://enzyme.expasy.org/EC/1.1.1.22 EchoBASE EB3183 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3183 EcoGene EG13407 http://www.ecogene.org/geneInfo.php?eg_id=EG13407 EnsemblBacteria AAC75089 http://www.ensemblgenomes.org/id/AAC75089 EnsemblBacteria AAC75089 http://www.ensemblgenomes.org/id/AAC75089 EnsemblBacteria BAA15860 http://www.ensemblgenomes.org/id/BAA15860 EnsemblBacteria BAA15860 http://www.ensemblgenomes.org/id/BAA15860 EnsemblBacteria BAA15860 http://www.ensemblgenomes.org/id/BAA15860 EnsemblBacteria b2028 http://www.ensemblgenomes.org/id/b2028 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003979 GO_function GO:0051287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051287 GO_process GO:0006065 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006065 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GO_process GO:0009242 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009242 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.1040.10 http://www.cathdb.info/version/latest/superfamily/1.10.1040.10 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 946571 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946571 HOGENOM HOG000280378 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000280378&db=HOGENOM6 InParanoid P76373 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76373 IntAct P76373 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76373* IntEnz 1.1.1.22 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.22 InterPro IPR001732 http://www.ebi.ac.uk/interpro/entry/IPR001732 InterPro IPR008927 http://www.ebi.ac.uk/interpro/entry/IPR008927 InterPro IPR013328 http://www.ebi.ac.uk/interpro/entry/IPR013328 InterPro IPR014026 http://www.ebi.ac.uk/interpro/entry/IPR014026 InterPro IPR014027 http://www.ebi.ac.uk/interpro/entry/IPR014027 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR017476 http://www.ebi.ac.uk/interpro/entry/IPR017476 InterPro IPR028357 http://www.ebi.ac.uk/interpro/entry/IPR028357 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2010 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2010 KEGG_Gene eco:b2028 http://www.genome.jp/dbget-bin/www_bget?eco:b2028 KEGG_Orthology KO:K00012 http://www.genome.jp/dbget-bin/www_bget?KO:K00012 KEGG_Pathway ko00040 http://www.genome.jp/kegg-bin/show_pathway?ko00040 KEGG_Pathway ko00053 http://www.genome.jp/kegg-bin/show_pathway?ko00053 KEGG_Pathway ko00500 http://www.genome.jp/kegg-bin/show_pathway?ko00500 KEGG_Pathway ko00520 http://www.genome.jp/kegg-bin/show_pathway?ko00520 KEGG_Reaction rn:R00286 http://www.genome.jp/dbget-bin/www_bget?rn:R00286 OMA DVLFMGF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DVLFMGF PANTHER PTHR11374 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11374 PSORT swissprot:UDG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UDG_ECOLI PSORT-B swissprot:UDG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UDG_ECOLI PSORT2 swissprot:UDG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UDG_ECOLI Pfam PF00984 http://pfam.xfam.org/family/PF00984 Pfam PF03720 http://pfam.xfam.org/family/PF03720 Pfam PF03721 http://pfam.xfam.org/family/PF03721 Phobius swissprot:UDG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UDG_ECOLI PhylomeDB P76373 http://phylomedb.org/?seqid=P76373 ProteinModelPortal P76373 http://www.proteinmodelportal.org/query/uniprot/P76373 PubMed 12851388 http://www.ncbi.nlm.nih.gov/pubmed/12851388 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416532 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416532 RefSeq WP_000704857 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000704857 SMART SM00984 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00984 SMR P76373 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76373 STRING 511145.b2028 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2028&targetmode=cogs STRING COG1004 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1004&targetmode=cogs SUPFAM SSF48179 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48179 SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 SUPFAM SSF52413 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52413 TIGRFAMs TIGR03026 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03026 UniProtKB UDG_ECOLI http://www.uniprot.org/uniprot/UDG_ECOLI UniProtKB-AC P76373 http://www.uniprot.org/uniprot/P76373 charge swissprot:UDG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UDG_ECOLI eggNOG COG1004 http://eggnogapi.embl.de/nog_data/html/tree/COG1004 eggNOG ENOG4105C6Y http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C6Y epestfind swissprot:UDG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UDG_ECOLI garnier swissprot:UDG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UDG_ECOLI helixturnhelix swissprot:UDG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UDG_ECOLI hmoment swissprot:UDG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UDG_ECOLI iep swissprot:UDG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UDG_ECOLI inforesidue swissprot:UDG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UDG_ECOLI octanol swissprot:UDG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UDG_ECOLI pepcoil swissprot:UDG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UDG_ECOLI pepdigest swissprot:UDG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UDG_ECOLI pepinfo swissprot:UDG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UDG_ECOLI pepnet swissprot:UDG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UDG_ECOLI pepstats swissprot:UDG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UDG_ECOLI pepwheel swissprot:UDG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UDG_ECOLI pepwindow swissprot:UDG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UDG_ECOLI sigcleave swissprot:UDG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UDG_ECOLI ## Database ID URL or Descriptions # BioGrid 4262674 320 # EcoGene EG11943 yjcH # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR007436 DUF485 # Organism YJCH_ECOLI Escherichia coli (strain K12) # PATRIC 32123685 VBIEscCol129921_4191 # PIR C65215 C65215 # Pfam PF04341 DUF485 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJCH_ECOLI Inner membrane protein YjcH # RefSeq NP_418492 NC_000913.3 # RefSeq WP_001014565 NZ_LN832404.1 # SUBCELLULAR LOCATION YJCH_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 9.B.136.1 the 2tms membrane protein, yjch (yjch) family # eggNOG COG3162 LUCA # eggNOG ENOG41062QD Bacteria BLAST swissprot:YJCH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJCH_ECOLI BioCyc ECOL316407:JW4029-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4029-MONOMER BioCyc EcoCyc:YJCH-MONOMER http://biocyc.org/getid?id=EcoCyc:YJCH-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1887 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1887 EcoGene EG11943 http://www.ecogene.org/geneInfo.php?eg_id=EG11943 EnsemblBacteria AAC77038 http://www.ensemblgenomes.org/id/AAC77038 EnsemblBacteria AAC77038 http://www.ensemblgenomes.org/id/AAC77038 EnsemblBacteria BAE78070 http://www.ensemblgenomes.org/id/BAE78070 EnsemblBacteria BAE78070 http://www.ensemblgenomes.org/id/BAE78070 EnsemblBacteria BAE78070 http://www.ensemblgenomes.org/id/BAE78070 EnsemblBacteria b4068 http://www.ensemblgenomes.org/id/b4068 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 948574 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948574 HOGENOM HOG000242230 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000242230&db=HOGENOM6 InParanoid P0AF54 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AF54 InterPro IPR007436 http://www.ebi.ac.uk/interpro/entry/IPR007436 KEGG_Gene ecj:JW4029 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4029 KEGG_Gene eco:b4068 http://www.genome.jp/dbget-bin/www_bget?eco:b4068 OMA KRGRFAW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KRGRFAW PSORT swissprot:YJCH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJCH_ECOLI PSORT-B swissprot:YJCH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJCH_ECOLI PSORT2 swissprot:YJCH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJCH_ECOLI Pfam PF04341 http://pfam.xfam.org/family/PF04341 Phobius swissprot:YJCH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJCH_ECOLI PhylomeDB P0AF54 http://phylomedb.org/?seqid=P0AF54 ProteinModelPortal P0AF54 http://www.proteinmodelportal.org/query/uniprot/P0AF54 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418492 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418492 RefSeq WP_001014565 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001014565 STRING 511145.b4068 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4068&targetmode=cogs TCDB 9.B.136.1 http://www.tcdb.org/search/result.php?tc=9.B.136.1 UniProtKB YJCH_ECOLI http://www.uniprot.org/uniprot/YJCH_ECOLI UniProtKB-AC P0AF54 http://www.uniprot.org/uniprot/P0AF54 charge swissprot:YJCH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJCH_ECOLI eggNOG COG3162 http://eggnogapi.embl.de/nog_data/html/tree/COG3162 eggNOG ENOG41062QD http://eggnogapi.embl.de/nog_data/html/tree/ENOG41062QD epestfind swissprot:YJCH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJCH_ECOLI garnier swissprot:YJCH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJCH_ECOLI helixturnhelix swissprot:YJCH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJCH_ECOLI hmoment swissprot:YJCH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJCH_ECOLI iep swissprot:YJCH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJCH_ECOLI inforesidue swissprot:YJCH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJCH_ECOLI octanol swissprot:YJCH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJCH_ECOLI pepcoil swissprot:YJCH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJCH_ECOLI pepdigest swissprot:YJCH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJCH_ECOLI pepinfo swissprot:YJCH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJCH_ECOLI pepnet swissprot:YJCH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJCH_ECOLI pepstats swissprot:YJCH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJCH_ECOLI pepwheel swissprot:YJCH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJCH_ECOLI pepwindow swissprot:YJCH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJCH_ECOLI sigcleave swissprot:YJCH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJCH_ECOLI ## Database ID URL or Descriptions # AltName PBP7_ECOLI Penicillin-binding protein 7 # BioGrid 4260453 227 # DrugBank DB01331 Cefoxitin # EcoGene EG12015 pbpG # FUNCTION PBP7_ECOLI Cell wall formation. May play a specialized role in remodeling the cell wall. Specifically hydrolyzes the DD- diaminopimelate-alanine bonds in high-molecular-mass murein sacculi. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_function GO:0004175 endopeptidase activity; IDA:EcoCyc. # GO_function GO:0009002 serine-type D-Ala-D-Ala carboxypeptidase activity; IBA:GO_Central. # GO_process GO:0000270 peptidoglycan metabolic process; IDA:EcoCyc. # GO_process GO:0008360 regulation of cell shape; IEA:UniProtKB-KW. # GO_process GO:0009252 peptidoglycan biosynthetic process; IBA:GO_Central. # GO_process GO:0042493 response to drug; IDA:EcoCyc. # GO_process GO:0043093 FtsZ-dependent cytokinesis; IMP:EcoCyc. # GO_process GO:0071555 cell wall organization; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0008233 peptidase activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 3.40.710.10 -; 1. # IntAct P0AFI5 8 # InterPro IPR001967 Peptidase_S11_N # InterPro IPR012338 Beta-lactam/transpept-like # InterPro IPR018044 Peptidase_S11 # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # MISCELLANEOUS In E.coli there are three murein endopeptidases two are penicillin sensitive (DacB and PbpG), the other (MepA) not. # Organism PBP7_ECOLI Escherichia coli (strain K12) # PATRIC 32119609 VBIEscCol129921_2215 # PIR E64981 E64981 # PRINTS PR00725 DADACBPTASE1 # PTM PBP7_ECOLI Pbp8 is a proteolytic product of Pbp7. # Pfam PF00768 Peptidase_S11 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PBP7_ECOLI D-alanyl-D-alanine endopeptidase # RefSeq NP_416638 NC_000913.3 # RefSeq WP_001319943 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA60496.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the peptidase S11 family. {ECO 0000305}. # SUBCELLULAR LOCATION PBP7_ECOLI Periplasm. # SUPFAM SSF56601 SSF56601 # eggNOG COG1686 LUCA # eggNOG ENOG41061WM Bacteria BLAST swissprot:PBP7_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PBP7_ECOLI BioCyc ECOL316407:JW5355-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5355-MONOMER BioCyc EcoCyc:EG12015-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12015-MONOMER BioCyc MetaCyc:EG12015-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12015-MONOMER COG COG1686 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1686 DIP DIP-48108N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48108N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1432-1033.1984.tb08473.x http://dx.doi.org/10.1111/j.1432-1033.1984.tb08473.x DOI 10.1111/j.1432-1033.1994.00597.x http://dx.doi.org/10.1111/j.1432-1033.1994.00597.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB01331 http://www.drugbank.ca/drugs/DB01331 EC_number EC:3.4.21.- http://www.genome.jp/dbget-bin/www_bget?EC:3.4.21.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X01067 http://www.ebi.ac.uk/ena/data/view/X01067 ENZYME 3.4.21.- http://enzyme.expasy.org/EC/3.4.21.- EchoBASE EB1952 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1952 EcoGene EG12015 http://www.ecogene.org/geneInfo.php?eg_id=EG12015 EnsemblBacteria AAC75195 http://www.ensemblgenomes.org/id/AAC75195 EnsemblBacteria AAC75195 http://www.ensemblgenomes.org/id/AAC75195 EnsemblBacteria BAE76611 http://www.ensemblgenomes.org/id/BAE76611 EnsemblBacteria BAE76611 http://www.ensemblgenomes.org/id/BAE76611 EnsemblBacteria BAE76611 http://www.ensemblgenomes.org/id/BAE76611 EnsemblBacteria b2134 http://www.ensemblgenomes.org/id/b2134 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0004175 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004175 GO_function GO:0009002 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009002 GO_process GO:0000270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000270 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0009252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009252 GO_process GO:0042493 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493 GO_process GO:0043093 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043093 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 3.40.710.10 http://www.cathdb.info/version/latest/superfamily/3.40.710.10 GeneID 946662 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946662 HOGENOM HOG000199620 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000199620&db=HOGENOM6 InParanoid P0AFI5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFI5 IntAct P0AFI5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFI5* IntEnz 3.4.21 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.21 InterPro IPR001967 http://www.ebi.ac.uk/interpro/entry/IPR001967 InterPro IPR012338 http://www.ebi.ac.uk/interpro/entry/IPR012338 InterPro IPR018044 http://www.ebi.ac.uk/interpro/entry/IPR018044 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW5355 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5355 KEGG_Gene eco:b2134 http://www.genome.jp/dbget-bin/www_bget?eco:b2134 KEGG_Orthology KO:K07262 http://www.genome.jp/dbget-bin/www_bget?KO:K07262 OMA TIYLALQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TIYLALQ PRINTS PR00725 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00725 PSORT swissprot:PBP7_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PBP7_ECOLI PSORT-B swissprot:PBP7_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PBP7_ECOLI PSORT2 swissprot:PBP7_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PBP7_ECOLI Pfam PF00768 http://pfam.xfam.org/family/PF00768 Phobius swissprot:PBP7_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PBP7_ECOLI PhylomeDB P0AFI5 http://phylomedb.org/?seqid=P0AFI5 ProteinModelPortal P0AFI5 http://www.proteinmodelportal.org/query/uniprot/P0AFI5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6386470 http://www.ncbi.nlm.nih.gov/pubmed/6386470 PubMed 7721700 http://www.ncbi.nlm.nih.gov/pubmed/7721700 PubMed 7925376 http://www.ncbi.nlm.nih.gov/pubmed/7925376 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416638 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416638 RefSeq WP_001319943 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001319943 SMR P0AFI5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFI5 STRING 511145.b2134 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2134&targetmode=cogs STRING COG1686 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1686&targetmode=cogs SUPFAM SSF56601 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56601 UniProtKB PBP7_ECOLI http://www.uniprot.org/uniprot/PBP7_ECOLI UniProtKB-AC P0AFI5 http://www.uniprot.org/uniprot/P0AFI5 charge swissprot:PBP7_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PBP7_ECOLI eggNOG COG1686 http://eggnogapi.embl.de/nog_data/html/tree/COG1686 eggNOG ENOG41061WM http://eggnogapi.embl.de/nog_data/html/tree/ENOG41061WM epestfind swissprot:PBP7_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PBP7_ECOLI garnier swissprot:PBP7_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PBP7_ECOLI helixturnhelix swissprot:PBP7_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PBP7_ECOLI hmoment swissprot:PBP7_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PBP7_ECOLI iep swissprot:PBP7_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PBP7_ECOLI inforesidue swissprot:PBP7_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PBP7_ECOLI octanol swissprot:PBP7_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PBP7_ECOLI pepcoil swissprot:PBP7_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PBP7_ECOLI pepdigest swissprot:PBP7_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PBP7_ECOLI pepinfo swissprot:PBP7_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PBP7_ECOLI pepnet swissprot:PBP7_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PBP7_ECOLI pepstats swissprot:PBP7_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PBP7_ECOLI pepwheel swissprot:PBP7_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PBP7_ECOLI pepwindow swissprot:PBP7_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PBP7_ECOLI sigcleave swissprot:PBP7_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PBP7_ECOLI ## Database ID URL or Descriptions # BioGrid 4262373 10 # EcoGene EG11803 hybE # GO_function GO:0070678 preprotein binding; IPI:EcoCyc. # GO_process GO:0051604 protein maturation; IMP:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0051604 protein maturation # INTERACTION HYBE_ECOLI P69741 hybO; NbExp=4; IntAct=EBI-552588, EBI-552619; # IntAct P0AAN1 7 # InterPro IPR023994 NiFe-hyd_HybE # Organism HYBE_ECOLI Escherichia coli (strain K12) # PATRIC 32121400 VBIEscCol129921_3087 # PDB 2KC5 NMR; -; A=1-162 # PIR F65085 F65085 # Pfam PF11939 NiFe-hyd_HybE # ProDom PD008308 PD008308 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HYBE_ECOLI Hydrogenase-2 operon protein HybE # RefSeq NP_417466 NC_000913.3 # RefSeq WP_000134014 NZ_LN832404.1 # SIMILARITY Belongs to the HupJ family. {ECO 0000305}. # TIGRFAMs TIGR03993 hydrog_HybE # eggNOG ENOG4108WGS Bacteria # eggNOG ENOG4111JT6 LUCA BLAST swissprot:HYBE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HYBE_ECOLI BioCyc ECOL316407:JW2960-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2960-MONOMER BioCyc EcoCyc:EG11803-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11803-MONOMER DIP DIP-35795N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35795N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U09177 http://www.ebi.ac.uk/ena/data/view/U09177 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB1751 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1751 EcoGene EG11803 http://www.ecogene.org/geneInfo.php?eg_id=EG11803 EnsemblBacteria AAC76028 http://www.ensemblgenomes.org/id/AAC76028 EnsemblBacteria AAC76028 http://www.ensemblgenomes.org/id/AAC76028 EnsemblBacteria BAE77053 http://www.ensemblgenomes.org/id/BAE77053 EnsemblBacteria BAE77053 http://www.ensemblgenomes.org/id/BAE77053 EnsemblBacteria BAE77053 http://www.ensemblgenomes.org/id/BAE77053 EnsemblBacteria b2992 http://www.ensemblgenomes.org/id/b2992 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0070678 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070678 GO_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 GeneID 947483 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947483 HOGENOM HOG000278778 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278778&db=HOGENOM6 InParanoid P0AAN1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAN1 IntAct P0AAN1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAN1* InterPro IPR023994 http://www.ebi.ac.uk/interpro/entry/IPR023994 KEGG_Gene ecj:JW2960 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2960 KEGG_Gene eco:b2992 http://www.genome.jp/dbget-bin/www_bget?eco:b2992 MINT MINT-1305432 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1305432 OMA LTPWMIS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LTPWMIS PDB 2KC5 http://www.ebi.ac.uk/pdbe-srv/view/entry/2KC5 PDBsum 2KC5 http://www.ebi.ac.uk/pdbsum/2KC5 PSORT swissprot:HYBE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HYBE_ECOLI PSORT-B swissprot:HYBE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HYBE_ECOLI PSORT2 swissprot:HYBE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HYBE_ECOLI Pfam PF11939 http://pfam.xfam.org/family/PF11939 Phobius swissprot:HYBE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HYBE_ECOLI ProteinModelPortal P0AAN1 http://www.proteinmodelportal.org/query/uniprot/P0AAN1 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8021226 http://www.ncbi.nlm.nih.gov/pubmed/8021226 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417466 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417466 RefSeq WP_000134014 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000134014 SMR P0AAN1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAN1 STRING 511145.b2992 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2992&targetmode=cogs TIGRFAMs TIGR03993 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03993 UniProtKB HYBE_ECOLI http://www.uniprot.org/uniprot/HYBE_ECOLI UniProtKB-AC P0AAN1 http://www.uniprot.org/uniprot/P0AAN1 charge swissprot:HYBE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HYBE_ECOLI eggNOG ENOG4108WGS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108WGS eggNOG ENOG4111JT6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111JT6 epestfind swissprot:HYBE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HYBE_ECOLI garnier swissprot:HYBE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HYBE_ECOLI helixturnhelix swissprot:HYBE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HYBE_ECOLI hmoment swissprot:HYBE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HYBE_ECOLI iep swissprot:HYBE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HYBE_ECOLI inforesidue swissprot:HYBE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HYBE_ECOLI octanol swissprot:HYBE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HYBE_ECOLI pepcoil swissprot:HYBE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HYBE_ECOLI pepdigest swissprot:HYBE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HYBE_ECOLI pepinfo swissprot:HYBE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HYBE_ECOLI pepnet swissprot:HYBE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HYBE_ECOLI pepstats swissprot:HYBE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HYBE_ECOLI pepwheel swissprot:HYBE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HYBE_ECOLI pepwindow swissprot:HYBE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HYBE_ECOLI sigcleave swissprot:HYBE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HYBE_ECOLI ## Database ID URL or Descriptions # BioGrid 4263089 5 # CDD cd06588 PhnB_like # EcoGene EG10712 yjdN # Gene3D 3.10.180.10 -; 1. # InterPro IPR028973 PhnB-like # InterPro IPR029068 Glyas_Bleomycin-R_OHBP_Dase # Organism PHNB_ECOLI Escherichia coli (strain K12) # PATRIC 32123773 VBIEscCol129921_4235 # PIR C35718 C35718 # Pfam PF06983 3-dmu-9_3-mt # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PHNB_ECOLI Protein PhnB # RefSeq NP_418531 NC_000913.3 # RefSeq WP_001131339 NZ_CP010444.1 # SUPFAM SSF54593 SSF54593 # eggNOG COG2764 LUCA # eggNOG ENOG4108SQ4 Bacteria BLAST swissprot:PHNB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PHNB_ECOLI BioCyc ECOL316407:JW4068-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4068-MONOMER BioCyc EcoCyc:EG10712-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10712-MONOMER COG COG2764 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2764 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J05260 http://www.ebi.ac.uk/ena/data/view/J05260 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB0706 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0706 EcoGene EG10712 http://www.ecogene.org/geneInfo.php?eg_id=EG10712 EnsemblBacteria AAC77068 http://www.ensemblgenomes.org/id/AAC77068 EnsemblBacteria AAC77068 http://www.ensemblgenomes.org/id/AAC77068 EnsemblBacteria BAE78109 http://www.ensemblgenomes.org/id/BAE78109 EnsemblBacteria BAE78109 http://www.ensemblgenomes.org/id/BAE78109 EnsemblBacteria BAE78109 http://www.ensemblgenomes.org/id/BAE78109 EnsemblBacteria b4107 http://www.ensemblgenomes.org/id/b4107 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.10.180.10 http://www.cathdb.info/version/latest/superfamily/3.10.180.10 GeneID 948622 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948622 HOGENOM HOG000232027 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000232027&db=HOGENOM6 InParanoid P16681 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P16681 IntAct P16681 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P16681* InterPro IPR028973 http://www.ebi.ac.uk/interpro/entry/IPR028973 InterPro IPR029068 http://www.ebi.ac.uk/interpro/entry/IPR029068 KEGG_Gene ecj:JW4068 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4068 KEGG_Gene eco:b4107 http://www.genome.jp/dbget-bin/www_bget?eco:b4107 KEGG_Orthology KO:K04750 http://www.genome.jp/dbget-bin/www_bget?KO:K04750 OMA WAARFGM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WAARFGM PSORT swissprot:PHNB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PHNB_ECOLI PSORT-B swissprot:PHNB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PHNB_ECOLI PSORT2 swissprot:PHNB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PHNB_ECOLI Pfam PF06983 http://pfam.xfam.org/family/PF06983 Phobius swissprot:PHNB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PHNB_ECOLI PhylomeDB P16681 http://phylomedb.org/?seqid=P16681 ProteinModelPortal P16681 http://www.proteinmodelportal.org/query/uniprot/P16681 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2155230 http://www.ncbi.nlm.nih.gov/pubmed/2155230 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418531 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418531 RefSeq WP_001131339 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001131339 SMR P16681 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P16681 STRING 511145.b4107 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4107&targetmode=cogs STRING COG2764 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2764&targetmode=cogs SUPFAM SSF54593 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54593 UniProtKB PHNB_ECOLI http://www.uniprot.org/uniprot/PHNB_ECOLI UniProtKB-AC P16681 http://www.uniprot.org/uniprot/P16681 charge swissprot:PHNB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PHNB_ECOLI eggNOG COG2764 http://eggnogapi.embl.de/nog_data/html/tree/COG2764 eggNOG ENOG4108SQ4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108SQ4 epestfind swissprot:PHNB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PHNB_ECOLI garnier swissprot:PHNB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PHNB_ECOLI helixturnhelix swissprot:PHNB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PHNB_ECOLI hmoment swissprot:PHNB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PHNB_ECOLI iep swissprot:PHNB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PHNB_ECOLI inforesidue swissprot:PHNB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PHNB_ECOLI octanol swissprot:PHNB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PHNB_ECOLI pepcoil swissprot:PHNB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PHNB_ECOLI pepdigest swissprot:PHNB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PHNB_ECOLI pepinfo swissprot:PHNB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PHNB_ECOLI pepnet swissprot:PHNB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PHNB_ECOLI pepstats swissprot:PHNB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PHNB_ECOLI pepwheel swissprot:PHNB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PHNB_ECOLI pepwindow swissprot:PHNB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PHNB_ECOLI sigcleave swissprot:PHNB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PHNB_ECOLI ## Database ID URL or Descriptions # BioGrid 4262664 13 # EcoGene EG10559 malM # FUNCTION MALM_ECOLI Not yet known. Might function in the uptake of a still unidentified substrate. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_process GO:0008643 carbohydrate transport; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0006810 transport # InterPro IPR010794 MalM # Organism MALM_ECOLI Escherichia coli (strain K12) # PATRIC 32123607 VBIEscCol129921_4152 # PIR A25787 BVECMM # Pfam PF07148 MalM # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MALM_ECOLI Maltose operon periplasmic protein # RefSeq NP_418461 NC_000913.3 # RefSeq WP_001326641 NZ_LN832404.1 # SIMILARITY To S.typhimurium MalM. {ECO 0000305}. # SUBCELLULAR LOCATION MALM_ECOLI Periplasm. # eggNOG ENOG4107W52 Bacteria # eggNOG ENOG410XQWW LUCA BLAST swissprot:MALM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MALM_ECOLI BioCyc ECOL316407:JW3997-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3997-MONOMER BioCyc EcoCyc:EG10559-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10559-MONOMER DIP DIP-10145N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10145N DOI 10.1016/0022-2836(86)90127-0 http://dx.doi.org/10.1016/0022-2836(86)90127-0 DOI 10.1016/0092-8674(81)90392-5 http://dx.doi.org/10.1016/0092-8674(81)90392-5 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01648 http://www.ebi.ac.uk/ena/data/view/J01648 EMBL M26131 http://www.ebi.ac.uk/ena/data/view/M26131 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00298 http://www.ebi.ac.uk/ena/data/view/V00298 EMBL X04477 http://www.ebi.ac.uk/ena/data/view/X04477 EchoBASE EB0554 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0554 EcoGene EG10559 http://www.ecogene.org/geneInfo.php?eg_id=EG10559 EnsemblBacteria AAC77007 http://www.ensemblgenomes.org/id/AAC77007 EnsemblBacteria AAC77007 http://www.ensemblgenomes.org/id/AAC77007 EnsemblBacteria BAE78039 http://www.ensemblgenomes.org/id/BAE78039 EnsemblBacteria BAE78039 http://www.ensemblgenomes.org/id/BAE78039 EnsemblBacteria BAE78039 http://www.ensemblgenomes.org/id/BAE78039 EnsemblBacteria b4037 http://www.ensemblgenomes.org/id/b4037 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_process GO:0008643 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008643 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948547 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948547 HOGENOM HOG000126874 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126874&db=HOGENOM6 InterPro IPR010794 http://www.ebi.ac.uk/interpro/entry/IPR010794 KEGG_Gene ecj:JW3997 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3997 KEGG_Gene eco:b4037 http://www.genome.jp/dbget-bin/www_bget?eco:b4037 KEGG_Orthology KO:K05775 http://www.genome.jp/dbget-bin/www_bget?KO:K05775 OMA NFVPQNT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NFVPQNT PSORT swissprot:MALM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MALM_ECOLI PSORT-B swissprot:MALM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MALM_ECOLI PSORT2 swissprot:MALM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MALM_ECOLI Pfam PF07148 http://pfam.xfam.org/family/PF07148 Phobius swissprot:MALM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MALM_ECOLI ProteinModelPortal P03841 http://www.proteinmodelportal.org/query/uniprot/P03841 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2434655 http://www.ncbi.nlm.nih.gov/pubmed/2434655 PubMed 6086106 http://www.ncbi.nlm.nih.gov/pubmed/6086106 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418461 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418461 RefSeq WP_001326641 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001326641 STRING 511145.b4037 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4037&targetmode=cogs UniProtKB MALM_ECOLI http://www.uniprot.org/uniprot/MALM_ECOLI UniProtKB-AC P03841 http://www.uniprot.org/uniprot/P03841 charge swissprot:MALM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MALM_ECOLI eggNOG ENOG4107W52 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107W52 eggNOG ENOG410XQWW http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQWW epestfind swissprot:MALM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MALM_ECOLI garnier swissprot:MALM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MALM_ECOLI helixturnhelix swissprot:MALM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MALM_ECOLI hmoment swissprot:MALM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MALM_ECOLI iep swissprot:MALM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MALM_ECOLI inforesidue swissprot:MALM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MALM_ECOLI octanol swissprot:MALM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MALM_ECOLI pepcoil swissprot:MALM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MALM_ECOLI pepdigest swissprot:MALM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MALM_ECOLI pepinfo swissprot:MALM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MALM_ECOLI pepnet swissprot:MALM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MALM_ECOLI pepstats swissprot:MALM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MALM_ECOLI pepwheel swissprot:MALM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MALM_ECOLI pepwindow swissprot:MALM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MALM_ECOLI sigcleave swissprot:MALM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MALM_ECOLI ## Database ID URL or Descriptions # AltName XYLA_ECOLI D-xylulose keto-isomerase # BioGrid 4262540 14 # CATALYTIC ACTIVITY XYLA_ECOLI D-xylopyranose = D-xylulose. # COFACTOR XYLA_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250}; Note=Binds 2 magnesium ions per subunit. {ECO 0000250}; # EcoGene EG11074 xylA # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0009045 xylose isomerase activity; IMP:CACAO. # GO_process GO:0006098 pentose-phosphate shunt; IEA:UniProtKB-HAMAP. # GO_process GO:0042843 D-xylose catabolic process; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.20.20.150 -; 1. # HAMAP MF_00455 Xylose_isom_A # IntAct P00944 8 # InterPro IPR001998 Xylose_isomerase # InterPro IPR013022 Xyl_isomerase-like_TIM-brl # InterPro IPR013452 Xylose_isom_bac # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00040 Pentose and glucuronate interconversions # KEGG_Pathway ko00051 Fructose and mannose metabolism # Organism XYLA_ECOLI Escherichia coli (strain K12) # PATRIC 32122606 VBIEscCol129921_3680 # PIR A30252 ISECX1 # PRINTS PR00688 XYLOSISMRASE # PROSITE PS51415 XYLOSE_ISOMERASE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName XYLA_ECOLI Xylose isomerase # RefSeq NP_418022 NC_000913.3 # RefSeq WP_001149591 NZ_CP014272.1 # SEQUENCE CAUTION Sequence=CAA25347.1; Type=Frameshift; Positions=67; Evidence={ECO:0000305}; Sequence=CAA28394.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the xylose isomerase family. {ECO 0000305}. # SUBCELLULAR LOCATION XYLA_ECOLI Cytoplasm. # SUBUNIT XYLA_ECOLI Homotetramer. # SUPFAM SSF51658 SSF51658 # TIGRFAMs TIGR02630 xylose_isom_A # eggNOG COG2115 LUCA # eggNOG ENOG4105C93 Bacteria BLAST swissprot:XYLA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:XYLA_ECOLI BioCyc ECOL316407:JW3537-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3537-MONOMER BioCyc EcoCyc:XYLISOM-MONOMER http://biocyc.org/getid?id=EcoCyc:XYLISOM-MONOMER BioCyc MetaCyc:XYLISOM-MONOMER http://biocyc.org/getid?id=MetaCyc:XYLISOM-MONOMER COG COG2115 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2115 DIP DIP-11149N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11149N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.87.2.618 http://dx.doi.org/10.1073/pnas.87.2.618 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.3.1.5 http://www.genome.jp/dbget-bin/www_bget?EC:5.3.1.5 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K01996 http://www.ebi.ac.uk/ena/data/view/K01996 EMBL S68257 http://www.ebi.ac.uk/ena/data/view/S68257 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X00772 http://www.ebi.ac.uk/ena/data/view/X00772 EMBL X00772 http://www.ebi.ac.uk/ena/data/view/X00772 EMBL X04691 http://www.ebi.ac.uk/ena/data/view/X04691 ENZYME 5.3.1.5 http://enzyme.expasy.org/EC/5.3.1.5 EchoBASE EB1067 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1067 EcoGene EG11074 http://www.ecogene.org/geneInfo.php?eg_id=EG11074 EnsemblBacteria AAC76589 http://www.ensemblgenomes.org/id/AAC76589 EnsemblBacteria AAC76589 http://www.ensemblgenomes.org/id/AAC76589 EnsemblBacteria BAE77728 http://www.ensemblgenomes.org/id/BAE77728 EnsemblBacteria BAE77728 http://www.ensemblgenomes.org/id/BAE77728 EnsemblBacteria BAE77728 http://www.ensemblgenomes.org/id/BAE77728 EnsemblBacteria b3565 http://www.ensemblgenomes.org/id/b3565 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0009045 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009045 GO_process GO:0006098 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006098 GO_process GO:0042843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042843 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.20.20.150 http://www.cathdb.info/version/latest/superfamily/3.20.20.150 GeneID 948141 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948141 HAMAP MF_00455 http://hamap.expasy.org/unirule/MF_00455 HOGENOM HOG000252293 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000252293&db=HOGENOM6 InParanoid P00944 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00944 IntAct P00944 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00944* IntEnz 5.3.1.5 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.3.1.5 InterPro IPR001998 http://www.ebi.ac.uk/interpro/entry/IPR001998 InterPro IPR013022 http://www.ebi.ac.uk/interpro/entry/IPR013022 InterPro IPR013452 http://www.ebi.ac.uk/interpro/entry/IPR013452 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3537 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3537 KEGG_Gene eco:b3565 http://www.genome.jp/dbget-bin/www_bget?eco:b3565 KEGG_Orthology KO:K01805 http://www.genome.jp/dbget-bin/www_bget?KO:K01805 KEGG_Pathway ko00040 http://www.genome.jp/kegg-bin/show_pathway?ko00040 KEGG_Pathway ko00051 http://www.genome.jp/kegg-bin/show_pathway?ko00051 KEGG_Reaction rn:R00878 http://www.genome.jp/dbget-bin/www_bget?rn:R00878 KEGG_Reaction rn:R01432 http://www.genome.jp/dbget-bin/www_bget?rn:R01432 MINT MINT-1238504 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1238504 OMA HTFQHEL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HTFQHEL PRINTS PR00688 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00688 PROSITE PS51415 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51415 PSORT swissprot:XYLA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:XYLA_ECOLI PSORT-B swissprot:XYLA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:XYLA_ECOLI PSORT2 swissprot:XYLA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:XYLA_ECOLI Phobius swissprot:XYLA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:XYLA_ECOLI PhylomeDB P00944 http://phylomedb.org/?seqid=P00944 ProteinModelPortal P00944 http://www.proteinmodelportal.org/query/uniprot/P00944 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2132127 http://www.ncbi.nlm.nih.gov/pubmed/2132127 PubMed 2405386 http://www.ncbi.nlm.nih.gov/pubmed/2405386 PubMed 6320721 http://www.ncbi.nlm.nih.gov/pubmed/6320721 PubMed 6325179 http://www.ncbi.nlm.nih.gov/pubmed/6325179 PubMed 6327696 http://www.ncbi.nlm.nih.gov/pubmed/6327696 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418022 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418022 RefSeq WP_001149591 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001149591 SMR P00944 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00944 STRING 511145.b3565 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3565&targetmode=cogs STRING COG2115 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2115&targetmode=cogs SUPFAM SSF51658 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51658 TIGRFAMs TIGR02630 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02630 UniProtKB XYLA_ECOLI http://www.uniprot.org/uniprot/XYLA_ECOLI UniProtKB-AC P00944 http://www.uniprot.org/uniprot/P00944 charge swissprot:XYLA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:XYLA_ECOLI eggNOG COG2115 http://eggnogapi.embl.de/nog_data/html/tree/COG2115 eggNOG ENOG4105C93 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C93 epestfind swissprot:XYLA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:XYLA_ECOLI garnier swissprot:XYLA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:XYLA_ECOLI helixturnhelix swissprot:XYLA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:XYLA_ECOLI hmoment swissprot:XYLA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:XYLA_ECOLI iep swissprot:XYLA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:XYLA_ECOLI inforesidue swissprot:XYLA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:XYLA_ECOLI octanol swissprot:XYLA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:XYLA_ECOLI pepcoil swissprot:XYLA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:XYLA_ECOLI pepdigest swissprot:XYLA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:XYLA_ECOLI pepinfo swissprot:XYLA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:XYLA_ECOLI pepnet swissprot:XYLA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:XYLA_ECOLI pepstats swissprot:XYLA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:XYLA_ECOLI pepwheel swissprot:XYLA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:XYLA_ECOLI pepwindow swissprot:XYLA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:XYLA_ECOLI sigcleave swissprot:XYLA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:XYLA_ECOLI ## Database ID URL or Descriptions # AltName FABF_ECOLI 3-oxoacyl-[acyl-carrier-protein] synthase II # AltName FABF_ECOLI Beta-ketoacyl-ACP synthase II # BRENDA 2.3.1.179 2026 # BioGrid 4260072 201 # CATALYTIC ACTIVITY (Z)-hexadec-11-enoyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = (Z)-3-oxooctadec-13-enoyl-[acyl- carrier-protein] + CO(2) + [acyl-carrier-protein]. {ECO:0000269|PubMed 9013860}. # DrugBank DB01034 Cerulenin # EcoGene EG12606 fabF # FUNCTION FABF_ECOLI Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthesis. {ECO 0000269|PubMed 6988423, ECO 0000269|PubMed 9013860}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity; IDA:EcoCyc. # GO_function GO:0033817 beta-ketoacyl-acyl-carrier-protein synthase II activity; IDA:CACAO. # GO_process GO:0006633 fatty acid biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.47.10 -; 2. # INTERACTION FABF_ECOLI P0A6Y8 dnaK; NbExp=2; IntAct=EBI-542783, EBI-542092; # IntAct P0AAI5 6 # InterPro IPR014030 Ketoacyl_synth_N # InterPro IPR014031 Ketoacyl_synth_C # InterPro IPR016039 Thiolase-like # InterPro IPR017568 3-oxoacyl-ACP_synth-2 # InterPro IPR018201 Ketoacyl_synth_AS # InterPro IPR020841 PKS_Beta-ketoAc_synthase_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01004 Lipid biosynthesis proteins # KEGG_Pathway ko00061 Fatty acid biosynthesis # KEGG_Pathway ko00780 Biotin metabolism # Organism FABF_ECOLI Escherichia coli (strain K12) # PATHWAY FABF_ECOLI Lipid metabolism; fatty acid biosynthesis. # PATRIC 32117431 VBIEscCol129921_1138 # PDB 1B3N X-ray; 2.65 A; A=2-413 # PDB 1KAS X-ray; 2.40 A; A=2-413 # PDB 2GFV X-ray; 2.29 A; A=2-413 # PDB 2GFW X-ray; 2.40 A; A=2-413 # PDB 2GFX X-ray; 2.59 A; A=2-413 # PDB 2GFY X-ray; 2.85 A; A=2-413 # PDB 3G0Y X-ray; 2.60 A; A=2-413 # PDB 3G11 X-ray; 2.00 A; A=2-413 # PDB 3HNZ X-ray; 2.75 A; A=2-413 # PDB 3HO2 X-ray; 2.00 A; A=2-413 # PDB 3HO9 X-ray; 1.90 A; A=2-413 # PDB 3I8P X-ray; 1.90 A; A=2-413 # PIR I41060 I41060 # PIRSF PIRSF000447 KAS_II # PROSITE PS00606 B_KETOACYL_SYNTHASE # Pfam PF00109 ketoacyl-synt # Pfam PF02801 Ketoacyl-synt_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FABF_ECOLI 3-oxoacyl-[acyl-carrier-protein] synthase 2 # RefSeq NP_415613 NC_000913.3 # RefSeq WP_000044679 NZ_LN832404.1 # SIMILARITY Belongs to the beta-ketoacyl-ACP synthases family. {ECO 0000305}. # SMART SM00825 PKS_KS # SUBUNIT FABF_ECOLI Homodimer. # SUPFAM SSF53901 SSF53901; 2 # TIGRFAMs TIGR03150 fabF # eggNOG COG0304 LUCA # eggNOG ENOG4105C0Q Bacteria BLAST swissprot:FABF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FABF_ECOLI BioCyc ECOL316407:JW1081-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1081-MONOMER BioCyc EcoCyc:3-OXOACYL-ACP-SYNTHII-MONOMER http://biocyc.org/getid?id=EcoCyc:3-OXOACYL-ACP-SYNTHII-MONOMER BioCyc MetaCyc:3-OXOACYL-ACP-SYNTHII-MONOMER http://biocyc.org/getid?id=MetaCyc:3-OXOACYL-ACP-SYNTHII-MONOMER COG COG0304 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0304 DIP DIP-29377N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-29377N DOI 10.1016/S0014-5793(96)01437-8 http://dx.doi.org/10.1016/S0014-5793(96)01437-8 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.91.23.11027 http://dx.doi.org/10.1073/pnas.91.23.11027 DOI 10.1074/jbc.274.10.6031 http://dx.doi.org/10.1074/jbc.274.10.6031 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/emboj/17.5.1183 http://dx.doi.org/10.1093/emboj/17.5.1183 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB01034 http://www.drugbank.ca/drugs/DB01034 EC_number EC:2.3.1.179 http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.179 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U20767 http://www.ebi.ac.uk/ena/data/view/U20767 EMBL Z34979 http://www.ebi.ac.uk/ena/data/view/Z34979 ENZYME 2.3.1.179 http://enzyme.expasy.org/EC/2.3.1.179 EchoBASE EB2490 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2490 EcoGene EG12606 http://www.ecogene.org/geneInfo.php?eg_id=EG12606 EnsemblBacteria AAC74179 http://www.ensemblgenomes.org/id/AAC74179 EnsemblBacteria AAC74179 http://www.ensemblgenomes.org/id/AAC74179 EnsemblBacteria BAA35903 http://www.ensemblgenomes.org/id/BAA35903 EnsemblBacteria BAA35903 http://www.ensemblgenomes.org/id/BAA35903 EnsemblBacteria BAA35903 http://www.ensemblgenomes.org/id/BAA35903 EnsemblBacteria b1095 http://www.ensemblgenomes.org/id/b1095 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004315 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004315 GO_function GO:0033817 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033817 GO_process GO:0006633 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006633 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.47.10 http://www.cathdb.info/version/latest/superfamily/3.40.47.10 GeneID 946665 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946665 HOGENOM HOG000060165 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000060165&db=HOGENOM6 InParanoid P0AAI5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAI5 IntAct P0AAI5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAI5* IntEnz 2.3.1.179 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.179 InterPro IPR014030 http://www.ebi.ac.uk/interpro/entry/IPR014030 InterPro IPR014031 http://www.ebi.ac.uk/interpro/entry/IPR014031 InterPro IPR016039 http://www.ebi.ac.uk/interpro/entry/IPR016039 InterPro IPR017568 http://www.ebi.ac.uk/interpro/entry/IPR017568 InterPro IPR018201 http://www.ebi.ac.uk/interpro/entry/IPR018201 InterPro IPR020841 http://www.ebi.ac.uk/interpro/entry/IPR020841 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01004 http://www.genome.jp/dbget-bin/www_bget?ko01004 KEGG_Gene ecj:JW1081 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1081 KEGG_Gene eco:b1095 http://www.genome.jp/dbget-bin/www_bget?eco:b1095 KEGG_Orthology KO:K09458 http://www.genome.jp/dbget-bin/www_bget?KO:K09458 KEGG_Pathway ko00061 http://www.genome.jp/kegg-bin/show_pathway?ko00061 KEGG_Pathway ko00780 http://www.genome.jp/kegg-bin/show_pathway?ko00780 KEGG_Reaction rn:R04355 http://www.genome.jp/dbget-bin/www_bget?rn:R04355 KEGG_Reaction rn:R04726 http://www.genome.jp/dbget-bin/www_bget?rn:R04726 KEGG_Reaction rn:R04952 http://www.genome.jp/dbget-bin/www_bget?rn:R04952 KEGG_Reaction rn:R04957 http://www.genome.jp/dbget-bin/www_bget?rn:R04957 KEGG_Reaction rn:R04960 http://www.genome.jp/dbget-bin/www_bget?rn:R04960 KEGG_Reaction rn:R04963 http://www.genome.jp/dbget-bin/www_bget?rn:R04963 KEGG_Reaction rn:R04968 http://www.genome.jp/dbget-bin/www_bget?rn:R04968 KEGG_Reaction rn:R07762 http://www.genome.jp/dbget-bin/www_bget?rn:R07762 KEGG_Reaction rn:R10115 http://www.genome.jp/dbget-bin/www_bget?rn:R10115 KEGG_Reaction rn:R10119 http://www.genome.jp/dbget-bin/www_bget?rn:R10119 MINT MINT-1231688 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1231688 OMA SIKHGFM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SIKHGFM PDB 1B3N http://www.ebi.ac.uk/pdbe-srv/view/entry/1B3N PDB 1KAS http://www.ebi.ac.uk/pdbe-srv/view/entry/1KAS PDB 2GFV http://www.ebi.ac.uk/pdbe-srv/view/entry/2GFV PDB 2GFW http://www.ebi.ac.uk/pdbe-srv/view/entry/2GFW PDB 2GFX http://www.ebi.ac.uk/pdbe-srv/view/entry/2GFX PDB 2GFY http://www.ebi.ac.uk/pdbe-srv/view/entry/2GFY PDB 3G0Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3G0Y PDB 3G11 http://www.ebi.ac.uk/pdbe-srv/view/entry/3G11 PDB 3HNZ http://www.ebi.ac.uk/pdbe-srv/view/entry/3HNZ PDB 3HO2 http://www.ebi.ac.uk/pdbe-srv/view/entry/3HO2 PDB 3HO9 http://www.ebi.ac.uk/pdbe-srv/view/entry/3HO9 PDB 3I8P http://www.ebi.ac.uk/pdbe-srv/view/entry/3I8P PDBsum 1B3N http://www.ebi.ac.uk/pdbsum/1B3N PDBsum 1KAS http://www.ebi.ac.uk/pdbsum/1KAS PDBsum 2GFV http://www.ebi.ac.uk/pdbsum/2GFV PDBsum 2GFW http://www.ebi.ac.uk/pdbsum/2GFW PDBsum 2GFX http://www.ebi.ac.uk/pdbsum/2GFX PDBsum 2GFY http://www.ebi.ac.uk/pdbsum/2GFY PDBsum 3G0Y http://www.ebi.ac.uk/pdbsum/3G0Y PDBsum 3G11 http://www.ebi.ac.uk/pdbsum/3G11 PDBsum 3HNZ http://www.ebi.ac.uk/pdbsum/3HNZ PDBsum 3HO2 http://www.ebi.ac.uk/pdbsum/3HO2 PDBsum 3HO9 http://www.ebi.ac.uk/pdbsum/3HO9 PDBsum 3I8P http://www.ebi.ac.uk/pdbsum/3I8P PROSITE PS00606 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00606 PSORT swissprot:FABF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FABF_ECOLI PSORT-B swissprot:FABF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FABF_ECOLI PSORT2 swissprot:FABF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FABF_ECOLI Pfam PF00109 http://pfam.xfam.org/family/PF00109 Pfam PF02801 http://pfam.xfam.org/family/PF02801 Phobius swissprot:FABF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FABF_ECOLI PhylomeDB P0AAI5 http://phylomedb.org/?seqid=P0AAI5 ProteinModelPortal P0AAI5 http://www.proteinmodelportal.org/query/uniprot/P0AAI5 PubMed 10037680 http://www.ncbi.nlm.nih.gov/pubmed/10037680 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3549687 http://www.ncbi.nlm.nih.gov/pubmed/3549687 PubMed 6988423 http://www.ncbi.nlm.nih.gov/pubmed/6988423 PubMed 7768872 http://www.ncbi.nlm.nih.gov/pubmed/7768872 PubMed 7972002 http://www.ncbi.nlm.nih.gov/pubmed/7972002 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9013860 http://www.ncbi.nlm.nih.gov/pubmed/9013860 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9482715 http://www.ncbi.nlm.nih.gov/pubmed/9482715 RefSeq NP_415613 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415613 RefSeq WP_000044679 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000044679 SMART SM00825 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00825 SMR P0AAI5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAI5 STRING 511145.b1095 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1095&targetmode=cogs STRING COG0304 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0304&targetmode=cogs SUPFAM SSF53901 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53901 TIGRFAMs TIGR03150 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03150 UniProtKB FABF_ECOLI http://www.uniprot.org/uniprot/FABF_ECOLI UniProtKB-AC P0AAI5 http://www.uniprot.org/uniprot/P0AAI5 charge swissprot:FABF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FABF_ECOLI eggNOG COG0304 http://eggnogapi.embl.de/nog_data/html/tree/COG0304 eggNOG ENOG4105C0Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C0Q epestfind swissprot:FABF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FABF_ECOLI garnier swissprot:FABF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FABF_ECOLI helixturnhelix swissprot:FABF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FABF_ECOLI hmoment swissprot:FABF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FABF_ECOLI iep swissprot:FABF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FABF_ECOLI inforesidue swissprot:FABF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FABF_ECOLI octanol swissprot:FABF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FABF_ECOLI pepcoil swissprot:FABF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FABF_ECOLI pepdigest swissprot:FABF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FABF_ECOLI pepinfo swissprot:FABF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FABF_ECOLI pepnet swissprot:FABF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FABF_ECOLI pepstats swissprot:FABF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FABF_ECOLI pepwheel swissprot:FABF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FABF_ECOLI pepwindow swissprot:FABF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FABF_ECOLI sigcleave swissprot:FABF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FABF_ECOLI ## Database ID URL or Descriptions # BioGrid 4259713 12 # EcoGene EG12346 hokA # FUNCTION HOKA_ECOLI Overproduction is toxic. {ECO 0000269|PubMed 20105222}. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # INDUCTION May be repressed by MqsA. {ECO:0000269|PubMed 20105222}. # InterPro IPR000021 Hok/gef_toxin # InterPro IPR018084 Hok/gef_toxin_CS # Organism HOKA_ECOLI Escherichia coli (strain K12) # PATRIC 32122586 VBIEscCol129921_3670 # PRINTS PR00281 HOKGEFTOXIC # PROSITE PS00556 HOK_GEF # Pfam PF01848 HOK_GEF # ProDom PD005979 Hok/gef_toxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HOKA_ECOLI Protein HokA # RefSeq WP_001135732 NZ_LN832404.1 # RefSeq YP_026229 NC_000913.3 # SIMILARITY Belongs to the hok/gef family. {ECO 0000305}. # SUBCELLULAR LOCATION HOKA_ECOLI Membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. # TCDB 1.E.53.1 the toxic hok/gef protein (hok/gef) family # eggNOG ENOG41060TC Bacteria # eggNOG ENOG41129RB LUCA BLAST swissprot:HOKA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HOKA_ECOLI BioCyc ECOL316407:JW3526-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3526-MONOMER BioCyc EcoCyc:MONOMER0-1605 http://biocyc.org/getid?id=EcoCyc:MONOMER0-1605 DOI 10.1016/0968-0004(94)90067-1 http://dx.doi.org/10.1016/0968-0004(94)90067-1 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1999.01431.x http://dx.doi.org/10.1046/j.1365-2958.1999.01431.x DOI 10.1073/pnas.87.1.283 http://dx.doi.org/10.1073/pnas.87.1.283 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1111/j.1462-2920.2009.02147.x http://dx.doi.org/10.1111/j.1462-2920.2009.02147.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M30139 http://www.ebi.ac.uk/ena/data/view/M30139 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2250 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2250 EcoGene EG12346 http://www.ecogene.org/geneInfo.php?eg_id=EG12346 EnsemblBacteria AAT48191 http://www.ensemblgenomes.org/id/AAT48191 EnsemblBacteria AAT48191 http://www.ensemblgenomes.org/id/AAT48191 EnsemblBacteria BAE77738 http://www.ensemblgenomes.org/id/BAE77738 EnsemblBacteria BAE77738 http://www.ensemblgenomes.org/id/BAE77738 EnsemblBacteria BAE77738 http://www.ensemblgenomes.org/id/BAE77738 EnsemblBacteria b4455 http://www.ensemblgenomes.org/id/b4455 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GeneID 2847732 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2847732 HOGENOM HOG000041219 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000041219&db=HOGENOM6 IntAct P37305 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37305* InterPro IPR000021 http://www.ebi.ac.uk/interpro/entry/IPR000021 InterPro IPR018084 http://www.ebi.ac.uk/interpro/entry/IPR018084 KEGG_Gene ecj:JW3526 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3526 KEGG_Gene eco:b4455 http://www.genome.jp/dbget-bin/www_bget?eco:b4455 OMA ICVTILC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ICVTILC PRINTS PR00281 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00281 PROSITE PS00556 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00556 PSORT swissprot:HOKA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HOKA_ECOLI PSORT-B swissprot:HOKA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HOKA_ECOLI PSORT2 swissprot:HOKA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HOKA_ECOLI Pfam PF01848 http://pfam.xfam.org/family/PF01848 Phobius swissprot:HOKA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HOKA_ECOLI PhylomeDB P37305 http://phylomedb.org/?seqid=P37305 ProteinModelPortal P37305 http://www.proteinmodelportal.org/query/uniprot/P37305 PubMed 10361310 http://www.ncbi.nlm.nih.gov/pubmed/10361310 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20105222 http://www.ncbi.nlm.nih.gov/pubmed/20105222 PubMed 2404279 http://www.ncbi.nlm.nih.gov/pubmed/2404279 PubMed 7940673 http://www.ncbi.nlm.nih.gov/pubmed/7940673 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001135732 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001135732 RefSeq YP_026229 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026229 STRING 511145.b4455 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4455&targetmode=cogs TCDB 1.E.53.1 http://www.tcdb.org/search/result.php?tc=1.E.53.1 UniProtKB HOKA_ECOLI http://www.uniprot.org/uniprot/HOKA_ECOLI UniProtKB-AC P37305 http://www.uniprot.org/uniprot/P37305 charge swissprot:HOKA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HOKA_ECOLI eggNOG ENOG41060TC http://eggnogapi.embl.de/nog_data/html/tree/ENOG41060TC eggNOG ENOG41129RB http://eggnogapi.embl.de/nog_data/html/tree/ENOG41129RB epestfind swissprot:HOKA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HOKA_ECOLI garnier swissprot:HOKA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HOKA_ECOLI helixturnhelix swissprot:HOKA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HOKA_ECOLI hmoment swissprot:HOKA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HOKA_ECOLI iep swissprot:HOKA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HOKA_ECOLI inforesidue swissprot:HOKA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HOKA_ECOLI octanol swissprot:HOKA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HOKA_ECOLI pepcoil swissprot:HOKA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HOKA_ECOLI pepdigest swissprot:HOKA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HOKA_ECOLI pepinfo swissprot:HOKA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HOKA_ECOLI pepnet swissprot:HOKA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HOKA_ECOLI pepstats swissprot:HOKA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HOKA_ECOLI pepwheel swissprot:HOKA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HOKA_ECOLI pepwindow swissprot:HOKA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HOKA_ECOLI sigcleave swissprot:HOKA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HOKA_ECOLI ## Database ID URL or Descriptions # EcoGene EG10866 rplC # FUNCTION RL3_ECOLI One of two assembly initiator proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. {ECO 0000269|PubMed 3298242, ECO 0000269|PubMed 6760192}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0022625 cytosolic large ribosomal subunit; IDA:EcoCyc. # GO_function GO:0003735 structural constituent of ribosome; IEA:InterPro. # GO_function GO:0019843 rRNA binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006412 translation; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_function GO:0019843 rRNA binding # GOslim_process GO:0006412 translation # HAMAP MF_01325_B Ribosomal_L3_B # IntAct P60438 144 # InterPro IPR000597 Ribosomal_L3 # InterPro IPR009000 Transl_B-barrel # InterPro IPR019926 Ribosomal_L3_CS # InterPro IPR019927 Ribosomal_L3_bac/org-type # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 M00179 Ribosome, archaea # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=22257.2; Method=MALDI; Range=1-209; Evidence={ECO:0000269|PubMed 10094780}; # Organism RL3_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11229 PTHR11229 # PATRIC 32122072 VBIEscCol129921_3413 # PDB 1ML5 EM; 14.00 A; e=2-209 # PDB 2J28 EM; 8.00 A; D=1-209 # PDB 2RDO EM; 9.10 A; D=1-209 # PDB 3BBX EM; 10.00 A; D=1-209 # PDB 3J5L EM; 6.60 A; D=1-209 # PDB 3J7Z EM; 3.90 A; D=1-209 # PDB 3J8G EM; 5.00 A; D=1-209 # PDB 3J9Y EM; 3.90 A; D=1-209 # PDB 3J9Z EM; 3.60 A; LX=1-209 # PDB 3JA1 EM; 3.60 A; LE=1-209 # PDB 3JBU EM; 3.64 A; d=1-209 # PDB 3JBV EM; 3.32 A; d=1-209 # PDB 3JCD EM; 3.70 A; D=1-209 # PDB 3JCE EM; 3.20 A; D=1-209 # PDB 3JCJ EM; 3.70 A; C=1-209 # PDB 3JCN EM; 4.60 A; D=1-209 # PDB 4CSU EM; 5.50 A; D=1-209 # PDB 4U1U X-ray; 2.95 A; BD/DD=1-209 # PDB 4U1V X-ray; 3.00 A; BD/DD=1-209 # PDB 4U20 X-ray; 2.90 A; BD/DD=1-209 # PDB 4U24 X-ray; 2.90 A; BD/DD=1-209 # PDB 4U25 X-ray; 2.90 A; BD/DD=1-209 # PDB 4U26 X-ray; 2.80 A; BD/DD=1-209 # PDB 4U27 X-ray; 2.80 A; BD/DD=1-209 # PDB 4UY8 EM; 3.80 A; D=1-209 # PDB 4V47 EM; 12.30 A; AB=1-209 # PDB 4V48 EM; 11.50 A; AB=1-209 # PDB 4V4H X-ray; 3.46 A; BD/DD=1-209 # PDB 4V4Q X-ray; 3.46 A; BD/DD=1-209 # PDB 4V4V EM; 15.00 A; BB=1-209 # PDB 4V4W EM; 15.00 A; BB=1-209 # PDB 4V50 X-ray; 3.22 A; BD/DD=1-209 # PDB 4V52 X-ray; 3.21 A; BD/DD=1-209 # PDB 4V53 X-ray; 3.54 A; BD/DD=1-209 # PDB 4V54 X-ray; 3.30 A; BD/DD=1-209 # PDB 4V55 X-ray; 4.00 A; BD/DD=1-209 # PDB 4V56 X-ray; 3.93 A; BD/DD=1-209 # PDB 4V57 X-ray; 3.50 A; BD/DD=1-209 # PDB 4V5B X-ray; 3.74 A; AD/CD=1-209 # PDB 4V5H EM; 5.80 A; BD=1-209 # PDB 4V5Y X-ray; 4.45 A; BD/DD=1-209 # PDB 4V64 X-ray; 3.50 A; BD/DD=1-209 # PDB 4V65 EM; 9.00 A; BY=1-209 # PDB 4V66 EM; 9.00 A; BY=1-209 # PDB 4V69 EM; 6.70 A; BD=1-209 # PDB 4V6C X-ray; 3.19 A; BD/DD=1-209 # PDB 4V6D X-ray; 3.81 A; BD/DD=1-209 # PDB 4V6E X-ray; 3.71 A; BD/DD=1-209 # PDB 4V6K EM; 8.25 A; AE=1-209 # PDB 4V6L EM; 13.20 A; BE=1-209 # PDB 4V6M EM; 7.10 A; BD=1-209 # PDB 4V6N EM; 12.10 A; AE=1-209 # PDB 4V6O EM; 14.70 A; BE=1-209 # PDB 4V6P EM; 13.50 A; BE=1-209 # PDB 4V6Q EM; 11.50 A; BE=1-209 # PDB 4V6R EM; 11.50 A; BE=1-209 # PDB 4V6S EM; 13.10 A; AE=1-209 # PDB 4V6T EM; 8.30 A; BD=1-209 # PDB 4V6V EM; 9.80 A; BE=1-209 # PDB 4V6Y EM; 12.00 A; BD=1-209 # PDB 4V6Z EM; 12.00 A; BD=1-209 # PDB 4V70 EM; 17.00 A; BD=1-209 # PDB 4V71 EM; 20.00 A; BD=1-209 # PDB 4V72 EM; 13.00 A; BD=1-209 # PDB 4V73 EM; 15.00 A; BD=1-209 # PDB 4V74 EM; 17.00 A; BD=1-209 # PDB 4V75 EM; 12.00 A; BD=1-209 # PDB 4V76 EM; 17.00 A; BD=1-209 # PDB 4V77 EM; 17.00 A; BD=1-209 # PDB 4V78 EM; 20.00 A; BD=1-209 # PDB 4V79 EM; 15.00 A; BD=1-209 # PDB 4V7A EM; 9.00 A; BD=1-209 # PDB 4V7B EM; 6.80 A; BD=1-209 # PDB 4V7C EM; 7.60 A; BE=1-209 # PDB 4V7D EM; 7.60 A; AE=1-209 # PDB 4V7I EM; 9.60 A; AD=1-209 # PDB 4V7S X-ray; 3.25 A; BD/DD=1-209 # PDB 4V7T X-ray; 3.19 A; BD/DD=1-209 # PDB 4V7U X-ray; 3.10 A; BD/DD=1-209 # PDB 4V7V X-ray; 3.29 A; BD/DD=1-209 # PDB 4V85 X-ray; 3.20 A; D=1-209 # PDB 4V89 X-ray; 3.70 A; BD=1-209 # PDB 4V9C X-ray; 3.30 A; BD/DD=1-209 # PDB 4V9D X-ray; 3.00 A; CD/DD=1-209 # PDB 4V9O X-ray; 2.90 A; AD/CD/ED/GD=1-209 # PDB 4V9P X-ray; 2.90 A; AD/CD/ED/GD=1-209 # PDB 4WF1 X-ray; 3.09 A; BD/DD=1-209 # PDB 4WOI X-ray; 3.00 A; BD/CD=1-209 # PDB 4WWW X-ray; 3.10 A; RD/YD=1-209 # PDB 4YBB X-ray; 2.10 A; CD/DD=1-209 # PDB 5ADY EM; 4.50 A; D=1-209 # PDB 5AFI EM; 2.90 A; D=1-209 # PDB 5AKA EM; 5.70 A; D=1-209 # PDB 5GAD EM; 3.70 A; D=1-209 # PDB 5GAE EM; 3.33 A; D=1-209 # PDB 5GAF EM; 4.30 A; D=1-209 # PDB 5GAG EM; 3.80 A; D=1-209 # PDB 5GAH EM; 3.80 A; D=1-209 # PDB 5IQR EM; 3.00 A; C=1-209 # PDB 5IT8 X-ray; 3.12 A; CD/DD=1-209 # PDB 5J5B X-ray; 2.80 A; CD/DD=1-209 # PDB 5J7L X-ray; 3.00 A; CD/DD=1-209 # PDB 5J88 X-ray; 3.32 A; CD/DD=1-209 # PDB 5J8A X-ray; 3.10 A; CD/DD=1-209 # PDB 5J91 X-ray; 2.96 A; CD/DD=1-209 # PDB 5JC9 X-ray; 3.03 A; CD/DD=1-209 # PDB 5JTE EM; 3.60 A; BD=1-209 # PDB 5JU8 EM; 3.60 A; BD=1-209 # PDB 5KCR EM; 3.60 A; 1E=1-209 # PDB 5KCS EM; 3.90 A; 1E=1-209 # PDB 5KPS EM; 3.90 A; C=1-209 # PDB 5KPV EM; 4.10 A; B=1-209 # PDB 5KPW EM; 3.90 A; B=1-209 # PDB 5KPX EM; 3.90 A; B=1-209 # PDB 5L3P EM; 3.70 A; E=1-209 # PIR A02757 R5EC3 # PROSITE PS00474 RIBOSOMAL_L3 # PTM RL3_ECOLI Methylated by PrmB. {ECO 0000269|PubMed 11847124}. # Pfam PF00297 Ribosomal_L3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RL3_ECOLI 50S ribosomal protein L3 # RefSeq NP_417779 NC_000913.3 # RefSeq WP_000579833 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein L3P family. {ECO 0000305}. # SUBUNIT RL3_ECOLI Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19. # SUPFAM SSF50447 SSF50447 # TIGRFAMs TIGR03625 L3_bact # eggNOG COG0087 LUCA # eggNOG ENOG4105EEE Bacteria BLAST swissprot:RL3_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RL3_ECOLI BioCyc ECOL316407:JW3282-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3282-MONOMER BioCyc EcoCyc:EG10866-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10866-MONOMER BioCyc MetaCyc:EG10866-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10866-MONOMER COG COG0087 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0087 DIP DIP-10744N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10744N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1016/0014-5793(78)80423-2 http://dx.doi.org/10.1016/0014-5793(78)80423-2 DOI 10.1016/0092-8674(81)90303-2 http://dx.doi.org/10.1016/0092-8674(81)90303-2 DOI 10.1016/S0092-8674(03)00427-6 http://dx.doi.org/10.1016/S0092-8674(03)00427-6 DOI 10.1016/j.celrep.2014.09.011 http://dx.doi.org/10.1016/j.celrep.2014.09.011 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nchembio.495 http://dx.doi.org/10.1038/nchembio.495 DOI 10.1073/pnas.79.23.7238 http://dx.doi.org/10.1073/pnas.79.23.7238 DOI 10.1093/emboj/21.4.769 http://dx.doi.org/10.1093/emboj/21.4.769 DOI 10.1093/nar/13.12.4521 http://dx.doi.org/10.1093/nar/13.12.4521 DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pbio.1001866 http://dx.doi.org/10.1371/journal.pbio.1001866 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL V00344 http://www.ebi.ac.uk/ena/data/view/V00344 EMBL X02613 http://www.ebi.ac.uk/ena/data/view/X02613 EchoBASE EB0859 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0859 EcoGene EG10866 http://www.ecogene.org/geneInfo.php?eg_id=EG10866 EnsemblBacteria AAC76345 http://www.ensemblgenomes.org/id/AAC76345 EnsemblBacteria AAC76345 http://www.ensemblgenomes.org/id/AAC76345 EnsemblBacteria BAE77971 http://www.ensemblgenomes.org/id/BAE77971 EnsemblBacteria BAE77971 http://www.ensemblgenomes.org/id/BAE77971 EnsemblBacteria BAE77971 http://www.ensemblgenomes.org/id/BAE77971 EnsemblBacteria b3320 http://www.ensemblgenomes.org/id/b3320 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0022625 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022625 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GeneID 947817 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947817 HAMAP MF_01325_B http://hamap.expasy.org/unirule/MF_01325_B HOGENOM HOG000100368 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000100368&db=HOGENOM6 InParanoid P60438 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P60438 IntAct P60438 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P60438* InterPro IPR000597 http://www.ebi.ac.uk/interpro/entry/IPR000597 InterPro IPR009000 http://www.ebi.ac.uk/interpro/entry/IPR009000 InterPro IPR019926 http://www.ebi.ac.uk/interpro/entry/IPR019926 InterPro IPR019927 http://www.ebi.ac.uk/interpro/entry/IPR019927 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW3282 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3282 KEGG_Gene eco:b3320 http://www.genome.jp/dbget-bin/www_bget?eco:b3320 KEGG_Orthology KO:K02906 http://www.genome.jp/dbget-bin/www_bget?KO:K02906 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 MINT MINT-1302843 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1302843 OMA KRMAGRY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KRMAGRY PANTHER PTHR11229 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11229 PDB 1ML5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ML5 PDB 2J28 http://www.ebi.ac.uk/pdbe-srv/view/entry/2J28 PDB 2RDO http://www.ebi.ac.uk/pdbe-srv/view/entry/2RDO PDB 3BBX http://www.ebi.ac.uk/pdbe-srv/view/entry/3BBX PDB 3J5L http://www.ebi.ac.uk/pdbe-srv/view/entry/3J5L PDB 3J7Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J7Z PDB 3J8G http://www.ebi.ac.uk/pdbe-srv/view/entry/3J8G PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 4CSU http://www.ebi.ac.uk/pdbe-srv/view/entry/4CSU PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4UY8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4UY8 PDB 4V47 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V47 PDB 4V48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V48 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5ADY http://www.ebi.ac.uk/pdbe-srv/view/entry/5ADY PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5AKA http://www.ebi.ac.uk/pdbe-srv/view/entry/5AKA PDB 5GAD http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAD PDB 5GAE http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAE PDB 5GAF http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAF PDB 5GAG http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAG PDB 5GAH http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAH PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 1ML5 http://www.ebi.ac.uk/pdbsum/1ML5 PDBsum 2J28 http://www.ebi.ac.uk/pdbsum/2J28 PDBsum 2RDO http://www.ebi.ac.uk/pdbsum/2RDO PDBsum 3BBX http://www.ebi.ac.uk/pdbsum/3BBX PDBsum 3J5L http://www.ebi.ac.uk/pdbsum/3J5L PDBsum 3J7Z http://www.ebi.ac.uk/pdbsum/3J7Z PDBsum 3J8G http://www.ebi.ac.uk/pdbsum/3J8G PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 4CSU http://www.ebi.ac.uk/pdbsum/4CSU PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4UY8 http://www.ebi.ac.uk/pdbsum/4UY8 PDBsum 4V47 http://www.ebi.ac.uk/pdbsum/4V47 PDBsum 4V48 http://www.ebi.ac.uk/pdbsum/4V48 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5ADY http://www.ebi.ac.uk/pdbsum/5ADY PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5AKA http://www.ebi.ac.uk/pdbsum/5AKA PDBsum 5GAD http://www.ebi.ac.uk/pdbsum/5GAD PDBsum 5GAE http://www.ebi.ac.uk/pdbsum/5GAE PDBsum 5GAF http://www.ebi.ac.uk/pdbsum/5GAF PDBsum 5GAG http://www.ebi.ac.uk/pdbsum/5GAG PDBsum 5GAH http://www.ebi.ac.uk/pdbsum/5GAH PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PROSITE PS00474 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00474 PSORT swissprot:RL3_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RL3_ECOLI PSORT-B swissprot:RL3_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RL3_ECOLI PSORT2 swissprot:RL3_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RL3_ECOLI Pfam PF00297 http://pfam.xfam.org/family/PF00297 Phobius swissprot:RL3_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RL3_ECOLI PhylomeDB P60438 http://phylomedb.org/?seqid=P60438 ProteinModelPortal P60438 http://www.proteinmodelportal.org/query/uniprot/P60438 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 11847124 http://www.ncbi.nlm.nih.gov/pubmed/11847124 PubMed 12809609 http://www.ncbi.nlm.nih.gov/pubmed/12809609 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21151122 http://www.ncbi.nlm.nih.gov/pubmed/21151122 PubMed 24844575 http://www.ncbi.nlm.nih.gov/pubmed/24844575 PubMed 25310980 http://www.ncbi.nlm.nih.gov/pubmed/25310980 PubMed 3298242 http://www.ncbi.nlm.nih.gov/pubmed/3298242 PubMed 365579 http://www.ncbi.nlm.nih.gov/pubmed/365579 PubMed 3892488 http://www.ncbi.nlm.nih.gov/pubmed/3892488 PubMed 6760192 http://www.ncbi.nlm.nih.gov/pubmed/6760192 PubMed 7037196 http://www.ncbi.nlm.nih.gov/pubmed/7037196 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_417779 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417779 RefSeq WP_000579833 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000579833 SMR P60438 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P60438 STRING 511145.b3320 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3320&targetmode=cogs STRING COG0087 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0087&targetmode=cogs SUPFAM SSF50447 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50447 TIGRFAMs TIGR03625 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03625 UniProtKB RL3_ECOLI http://www.uniprot.org/uniprot/RL3_ECOLI UniProtKB-AC P60438 http://www.uniprot.org/uniprot/P60438 charge swissprot:RL3_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RL3_ECOLI eggNOG COG0087 http://eggnogapi.embl.de/nog_data/html/tree/COG0087 eggNOG ENOG4105EEE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EEE epestfind swissprot:RL3_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RL3_ECOLI garnier swissprot:RL3_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RL3_ECOLI helixturnhelix swissprot:RL3_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RL3_ECOLI hmoment swissprot:RL3_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RL3_ECOLI iep swissprot:RL3_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RL3_ECOLI inforesidue swissprot:RL3_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RL3_ECOLI octanol swissprot:RL3_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RL3_ECOLI pepcoil swissprot:RL3_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RL3_ECOLI pepdigest swissprot:RL3_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RL3_ECOLI pepinfo swissprot:RL3_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RL3_ECOLI pepnet swissprot:RL3_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RL3_ECOLI pepstats swissprot:RL3_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RL3_ECOLI pepwheel swissprot:RL3_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RL3_ECOLI pepwindow swissprot:RL3_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RL3_ECOLI sigcleave swissprot:RL3_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RL3_ECOLI ## Database ID URL or Descriptions # AltName RCLA_ECOLI Reactive chlorine resistance protein A # BioGrid 4259800 10 # COFACTOR RCLA_ECOLI Name=FAD; Xref=ChEBI CHEBI 57692; Evidence={ECO 0000250}; Note=Binds 1 FAD per subunit. {ECO 0000250}; # DISRUPTION PHENOTYPE Mutants are more sensitive to HOCl treatment than wild-type cells. {ECO:0000269|PubMed 24078635}. # EcoGene EG13580 rclA # FUNCTION RCLA_ECOLI Probably involved in reactive chlorine species (RCS) stress resistance. {ECO 0000269|PubMed 24078635}. # GO_component GO:0005623 cell; IEA:GOC. # GO_function GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor; IEA:InterPro. # GO_function GO:0050660 flavin adenine dinucleotide binding; IEA:InterPro. # GO_process GO:0045454 cell redox homeostasis; IEA:InterPro. # GO_process GO:1901530 response to hypochlorite; IMP:EcoCyc. # GOslim_component GO:0005623 cell # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0042592 homeostatic process # Gene3D 3.30.390.30 -; 1. # Gene3D 3.50.50.60 -; 2. # INDUCTION Induced by RclR in response to hypochlorous acid (HOCl). {ECO:0000269|PubMed 24078635}. # IntAct P77212 2 # InterPro IPR004099 Pyr_nucl-diS_OxRdtase_dimer # InterPro IPR012999 Pyr_OxRdtase_I_AS # InterPro IPR016156 FAD/NAD-linked_Rdtase_dimer # InterPro IPR023753 FAD/NAD-binding_dom # MISCELLANEOUS The active site is a redox-active disulfide bond. {ECO 0000250}. # Organism RCLA_ECOLI Escherichia coli (strain K12) # PATRIC 32115737 VBIEscCol129921_0311 # PIR H64756 H64756 # PROSITE PS00076 PYRIDINE_REDOX_1 # Pfam PF02852 Pyr_redox_dim # Pfam PF07992 Pyr_redox_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RCLA_ECOLI Probable pyridine nucleotide-disulfide oxidoreductase RclA # RefSeq NP_414838 NC_000913.3 # RefSeq WP_001046307 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18031.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. {ECO 0000305}. # SUPFAM SSF51905 SSF51905 # SUPFAM SSF55424 SSF55424 # eggNOG COG1249 LUCA # eggNOG ENOG4107QN2 Bacteria BLAST swissprot:RCLA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RCLA_ECOLI BioCyc ECOL316407:JW5040-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5040-MONOMER BioCyc EcoCyc:G6174-MONOMER http://biocyc.org/getid?id=EcoCyc:G6174-MONOMER DIP DIP-12675N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12675N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M113.503516 http://dx.doi.org/10.1074/jbc.M113.503516 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB3350 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3350 EcoGene EG13580 http://www.ecogene.org/geneInfo.php?eg_id=EG13580 EnsemblBacteria AAC73407 http://www.ensemblgenomes.org/id/AAC73407 EnsemblBacteria AAC73407 http://www.ensemblgenomes.org/id/AAC73407 EnsemblBacteria BAE76088 http://www.ensemblgenomes.org/id/BAE76088 EnsemblBacteria BAE76088 http://www.ensemblgenomes.org/id/BAE76088 EnsemblBacteria BAE76088 http://www.ensemblgenomes.org/id/BAE76088 EnsemblBacteria b0304 http://www.ensemblgenomes.org/id/b0304 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005623 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005623 GO_function GO:0016668 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016668 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_process GO:0045454 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045454 GO_process GO:1901530 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901530 GOslim_component GO:0005623 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005623 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 Gene3D 3.30.390.30 http://www.cathdb.info/version/latest/superfamily/3.30.390.30 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 GeneID 946092 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946092 HOGENOM HOG000276709 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276709&db=HOGENOM6 InParanoid P77212 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77212 IntAct P77212 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77212* InterPro IPR004099 http://www.ebi.ac.uk/interpro/entry/IPR004099 InterPro IPR012999 http://www.ebi.ac.uk/interpro/entry/IPR012999 InterPro IPR016156 http://www.ebi.ac.uk/interpro/entry/IPR016156 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 KEGG_Gene ecj:JW5040 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5040 KEGG_Gene eco:b0304 http://www.genome.jp/dbget-bin/www_bget?eco:b0304 MINT MINT-1306527 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1306527 OMA MSYVARA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MSYVARA PROSITE PS00076 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00076 PSORT swissprot:RCLA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RCLA_ECOLI PSORT-B swissprot:RCLA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RCLA_ECOLI PSORT2 swissprot:RCLA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RCLA_ECOLI Pfam PF02852 http://pfam.xfam.org/family/PF02852 Pfam PF07992 http://pfam.xfam.org/family/PF07992 Phobius swissprot:RCLA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RCLA_ECOLI PhylomeDB P77212 http://phylomedb.org/?seqid=P77212 ProteinModelPortal P77212 http://www.proteinmodelportal.org/query/uniprot/P77212 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 24078635 http://www.ncbi.nlm.nih.gov/pubmed/24078635 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414838 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414838 RefSeq WP_001046307 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001046307 SMR P77212 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77212 STRING 511145.b0304 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0304&targetmode=cogs SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 SUPFAM SSF55424 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55424 UniProtKB RCLA_ECOLI http://www.uniprot.org/uniprot/RCLA_ECOLI UniProtKB-AC P77212 http://www.uniprot.org/uniprot/P77212 charge swissprot:RCLA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RCLA_ECOLI eggNOG COG1249 http://eggnogapi.embl.de/nog_data/html/tree/COG1249 eggNOG ENOG4107QN2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QN2 epestfind swissprot:RCLA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RCLA_ECOLI garnier swissprot:RCLA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RCLA_ECOLI helixturnhelix swissprot:RCLA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RCLA_ECOLI hmoment swissprot:RCLA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RCLA_ECOLI iep swissprot:RCLA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RCLA_ECOLI inforesidue swissprot:RCLA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RCLA_ECOLI octanol swissprot:RCLA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RCLA_ECOLI pepcoil swissprot:RCLA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RCLA_ECOLI pepdigest swissprot:RCLA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RCLA_ECOLI pepinfo swissprot:RCLA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RCLA_ECOLI pepnet swissprot:RCLA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RCLA_ECOLI pepstats swissprot:RCLA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RCLA_ECOLI pepwheel swissprot:RCLA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RCLA_ECOLI pepwindow swissprot:RCLA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RCLA_ECOLI sigcleave swissprot:RCLA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RCLA_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES TRKH_ECOLI Kinetic parameters KM=6 mM for K(+) {ECO 0000269|PubMed 7896723}; KM=2 mM for Rb(+) {ECO 0000269|PubMed 7896723}; Vmax=800 umol/min/g enzyme with K(+) as substrate {ECO 0000269|PubMed 7896723}; Vmax=10 umol/min/g enzyme with Rb(+) as substrate {ECO 0000269|PubMed 7896723}; # BioGrid 4262619 7 # EcoGene EG11021 trkH # FUNCTION TRKH_ECOLI Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA and requires TrkE for transport activity (By similarity). Can transport potassium and rubidium. {ECO 0000250, ECO 0000269|PubMed 7896723}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:UniProtKB. # GO_function GO:0005267 potassium channel activity; ISS:UniProtKB. # GO_function GO:0022820 potassium ion symporter activity; IEA:InterPro. # GO_function GO:0030955 potassium ion binding; ISS:UniProtKB. # GO_process GO:0071805 potassium ion transmembrane transport; ISS:UniProtKB. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0055085 transmembrane transport # IntAct P0AFZ7 2 # InterPro IPR003445 Cat_transpt # InterPro IPR004772 TrkH # Organism TRKH_ECOLI Escherichia coli (strain K12) # PATRIC 32123195 VBIEscCol129921_3963 # PIR B65190 B65190 # PIRSF PIRSF006247 TrkH # Pfam PF02386 TrkH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TRKH_ECOLI Trk system potassium uptake protein TrkH # RefSeq WP_000545677 NZ_LN832404.1 # RefSeq YP_026273 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA67646.1; Type=Frameshift; Positions=416; Evidence={ECO:0000305}; Sequence=X54687; Type=Frameshift; Positions=418, 420; Evidence={ECO 0000305}; # SIMILARITY Belongs to the TrkH potassium transport family. {ECO 0000305}. # SUBCELLULAR LOCATION TRKH_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # TCDB 2.A.38.1 the k(+) transporter (trk) family # TIGRFAMs TIGR00933 2a38 # eggNOG COG0168 LUCA # eggNOG ENOG4105D37 Bacteria BLAST swissprot:TRKH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRKH_ECOLI BioCyc ECOL316407:JW5576-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5576-MONOMER BioCyc EcoCyc:TRKH-MONOMER http://biocyc.org/getid?id=EcoCyc:TRKH-MONOMER BioCyc MetaCyc:TRKH-MONOMER http://biocyc.org/getid?id=MetaCyc:TRKH-MONOMER COG COG0168 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0168 DIP DIP-47978N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47978N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/18.21.6439 http://dx.doi.org/10.1093/nar/18.21.6439 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X54687 http://www.ebi.ac.uk/ena/data/view/X54687 EchoBASE EB1014 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1014 EcoGene EG11021 http://www.ecogene.org/geneInfo.php?eg_id=EG11021 EnsemblBacteria AAT48231 http://www.ensemblgenomes.org/id/AAT48231 EnsemblBacteria AAT48231 http://www.ensemblgenomes.org/id/AAT48231 EnsemblBacteria BAE77454 http://www.ensemblgenomes.org/id/BAE77454 EnsemblBacteria BAE77454 http://www.ensemblgenomes.org/id/BAE77454 EnsemblBacteria BAE77454 http://www.ensemblgenomes.org/id/BAE77454 EnsemblBacteria b3849 http://www.ensemblgenomes.org/id/b3849 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0005267 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005267 GO_function GO:0022820 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022820 GO_function GO:0030955 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030955 GO_process GO:0071805 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 948333 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948333 HOGENOM HOG000225541 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000225541&db=HOGENOM6 InParanoid P0AFZ7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFZ7 IntAct P0AFZ7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFZ7* InterPro IPR003445 http://www.ebi.ac.uk/interpro/entry/IPR003445 InterPro IPR004772 http://www.ebi.ac.uk/interpro/entry/IPR004772 KEGG_Gene ecj:JW5576 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5576 KEGG_Gene eco:b3849 http://www.genome.jp/dbget-bin/www_bget?eco:b3849 KEGG_Orthology KO:K03498 http://www.genome.jp/dbget-bin/www_bget?KO:K03498 MINT MINT-1238565 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1238565 OMA YRHLLQW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YRHLLQW PSORT swissprot:TRKH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRKH_ECOLI PSORT-B swissprot:TRKH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRKH_ECOLI PSORT2 swissprot:TRKH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRKH_ECOLI Pfam PF02386 http://pfam.xfam.org/family/PF02386 Phobius swissprot:TRKH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRKH_ECOLI PhylomeDB P0AFZ7 http://phylomedb.org/?seqid=P0AFZ7 ProteinModelPortal P0AFZ7 http://www.proteinmodelportal.org/query/uniprot/P0AFZ7 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2243799 http://www.ncbi.nlm.nih.gov/pubmed/2243799 PubMed 7896723 http://www.ncbi.nlm.nih.gov/pubmed/7896723 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000545677 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000545677 RefSeq YP_026273 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026273 SMR P0AFZ7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFZ7 STRING 511145.b3849 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3849&targetmode=cogs STRING COG0168 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0168&targetmode=cogs TCDB 2.A.38.1 http://www.tcdb.org/search/result.php?tc=2.A.38.1 TIGRFAMs TIGR00933 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00933 UniProtKB TRKH_ECOLI http://www.uniprot.org/uniprot/TRKH_ECOLI UniProtKB-AC P0AFZ7 http://www.uniprot.org/uniprot/P0AFZ7 charge swissprot:TRKH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRKH_ECOLI eggNOG COG0168 http://eggnogapi.embl.de/nog_data/html/tree/COG0168 eggNOG ENOG4105D37 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D37 epestfind swissprot:TRKH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRKH_ECOLI garnier swissprot:TRKH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRKH_ECOLI helixturnhelix swissprot:TRKH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRKH_ECOLI hmoment swissprot:TRKH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRKH_ECOLI iep swissprot:TRKH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRKH_ECOLI inforesidue swissprot:TRKH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRKH_ECOLI octanol swissprot:TRKH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRKH_ECOLI pepcoil swissprot:TRKH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRKH_ECOLI pepdigest swissprot:TRKH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRKH_ECOLI pepinfo swissprot:TRKH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRKH_ECOLI pepnet swissprot:TRKH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRKH_ECOLI pepstats swissprot:TRKH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRKH_ECOLI pepwheel swissprot:TRKH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRKH_ECOLI pepwindow swissprot:TRKH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRKH_ECOLI sigcleave swissprot:TRKH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRKH_ECOLI ## Database ID URL or Descriptions # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # ESTHER ecoli-yghX Dienelactone_hydrolase # EcoGene EG13008 yghX # GO_function GO:0016787 hydrolase activity; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # Gene3D 3.40.50.1820 -; 1. # InterPro IPR002925 Dienelactn_hydro # InterPro IPR029058 AB_hydrolase # Organism YGHX_ECOLI Escherichia coli (strain K12) # PIR E65086 E65086 # Pfam PF01738 DLH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGHX_ECOLI Putative uncharacterized protein YghX # SEQUENCE CAUTION Sequence=AAA69166.1; Type=Frameshift; Positions=141; Evidence={ECO:0000305}; Sequence=AP009048; Type=Frameshift; Positions=141; Evidence={ECO 0000305}; Sequence=U00096; Type=Frameshift; Positions=141; Evidence={ECO:0000305}; # SUPFAM SSF53474 SSF53474 BLAST swissprot:YGHX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGHX_ECOLI BioCyc EcoCyc:G7556-MONOMER http://biocyc.org/getid?id=EcoCyc:G7556-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EcoGene EG13008 http://www.ecogene.org/geneInfo.php?eg_id=EG13008 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016787 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016787 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 Gene3D 3.40.50.1820 http://www.cathdb.info/version/latest/superfamily/3.40.50.1820 HOGENOM HOG000157121 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000157121&db=HOGENOM6 InParanoid Q7DFU6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q7DFU6 IntAct Q7DFU6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q7DFU6* InterPro IPR002925 http://www.ebi.ac.uk/interpro/entry/IPR002925 InterPro IPR029058 http://www.ebi.ac.uk/interpro/entry/IPR029058 OMA WISNMMA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WISNMMA PSORT swissprot:YGHX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGHX_ECOLI PSORT-B swissprot:YGHX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGHX_ECOLI PSORT2 swissprot:YGHX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGHX_ECOLI Pfam PF01738 http://pfam.xfam.org/family/PF01738 Phobius swissprot:YGHX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGHX_ECOLI PhylomeDB Q7DFU6 http://phylomedb.org/?seqid=Q7DFU6 ProteinModelPortal Q7DFU6 http://www.proteinmodelportal.org/query/uniprot/Q7DFU6 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SMR Q7DFU6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q7DFU6 SUPFAM SSF53474 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53474 UniProtKB YGHX_ECOLI http://www.uniprot.org/uniprot/YGHX_ECOLI UniProtKB-AC Q7DFU6 http://www.uniprot.org/uniprot/Q7DFU6 charge swissprot:YGHX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGHX_ECOLI epestfind swissprot:YGHX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGHX_ECOLI garnier swissprot:YGHX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGHX_ECOLI helixturnhelix swissprot:YGHX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGHX_ECOLI hmoment swissprot:YGHX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGHX_ECOLI iep swissprot:YGHX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGHX_ECOLI inforesidue swissprot:YGHX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGHX_ECOLI octanol swissprot:YGHX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGHX_ECOLI pepcoil swissprot:YGHX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGHX_ECOLI pepdigest swissprot:YGHX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGHX_ECOLI pepinfo swissprot:YGHX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGHX_ECOLI pepnet swissprot:YGHX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGHX_ECOLI pepstats swissprot:YGHX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGHX_ECOLI pepwheel swissprot:YGHX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGHX_ECOLI pepwindow swissprot:YGHX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGHX_ECOLI sigcleave swissprot:YGHX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGHX_ECOLI ## Database ID URL or Descriptions # BRENDA 3.1.1.29 2026 # BioGrid 4262870 7 # CATALYTIC ACTIVITY N-substituted aminoacyl-tRNA + H(2)O = N- substituted amino acid + tRNA. {ECO:0000255|HAMAP-Rule MF_00083}. # CDD cd00462 PTH # EcoGene EG10785 pth # FUNCTION PTH_ECOLI The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis. Involved in lambda inhibition of host protein synthesis. PTH activity may, directly or indirectly, be the target for lambda bar RNA leading to rap cell death. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0004045 aminoacyl-tRNA hydrolase activity; IDA:EcoCyc. # GO_process GO:0006412 translation; IEA:UniProtKB-HAMAP. # GO_process GO:0006515 misfolded or incompletely synthesized protein catabolic process; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006412 translation # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.1470 -; 1. # HAMAP MF_00083 Pept_tRNA_hydro_bact # IntAct P0A7D1 15 # InterPro IPR001328 Pept_tRNA_hydro # InterPro IPR018171 Pept_tRNA_hydro_CS # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03012 Translation factors # Organism PTH_ECOLI Escherichia coli (strain K12) # PANTHER PTHR17224 PTHR17224 # PATRIC 32117660 VBIEscCol129921_1252 # PDB 2PTH X-ray; 1.20 A; A=2-194 # PDB 3VJR X-ray; 2.40 A; A/C=1-194 # PIR S16753 S16753 # PROSITE PS01195 PEPT_TRNA_HYDROL_1 # PROSITE PS01196 PEPT_TRNA_HYDROL_2 # Pfam PF01195 Pept_tRNA_hydro # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Peptidyl-tRNA hydrolase {ECO:0000255|HAMAP-Rule MF_00083} # RefSeq NP_415722 NC_000913.3 # RefSeq WP_000152933 NZ_LN832404.1 # SIMILARITY Belongs to the PTH family. {ECO:0000255|HAMAP- Rule MF_00083}. # SUBCELLULAR LOCATION PTH_ECOLI Cytoplasm. # SUBUNIT PTH_ECOLI Monomer. # SUPFAM SSF53178 SSF53178 # TIGRFAMs TIGR00447 pth # eggNOG COG0193 LUCA # eggNOG ENOG4108ZPD Bacteria BLAST swissprot:PTH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTH_ECOLI BioCyc ECOL316407:JW1195-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1195-MONOMER BioCyc EcoCyc:EG10785-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10785-MONOMER BioCyc MetaCyc:EG10785-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10785-MONOMER COG COG0193 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0193 DIP DIP-35932N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35932N DOI 10.1002/(SICI)1097-0134(199705)28:1<135::AID-PROT14>3.3.CO http://dx.doi.org/10.1002/(SICI)1097-0134(199705)28:1<135::AID-PROT14>3.3.CO DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/emboj/16.15.4760 http://dx.doi.org/10.1093/emboj/16.15.4760 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.1.29 {ECO:0000255|HAMAP-Rule:MF_00083} http://www.genome.jp/dbget-bin/www_bget?EC:3.1.1.29 {ECO:0000255|HAMAP-Rule:MF_00083} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X61941 http://www.ebi.ac.uk/ena/data/view/X61941 ENZYME 3.1.1.29 {ECO:0000255|HAMAP-Rule:MF_00083} http://enzyme.expasy.org/EC/3.1.1.29 {ECO:0000255|HAMAP-Rule:MF_00083} EchoBASE EB0778 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0778 EcoGene EG10785 http://www.ecogene.org/geneInfo.php?eg_id=EG10785 EnsemblBacteria AAC74288 http://www.ensemblgenomes.org/id/AAC74288 EnsemblBacteria AAC74288 http://www.ensemblgenomes.org/id/AAC74288 EnsemblBacteria BAA36062 http://www.ensemblgenomes.org/id/BAA36062 EnsemblBacteria BAA36062 http://www.ensemblgenomes.org/id/BAA36062 EnsemblBacteria BAA36062 http://www.ensemblgenomes.org/id/BAA36062 EnsemblBacteria b1204 http://www.ensemblgenomes.org/id/b1204 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004045 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004045 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GO_process GO:0006515 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006515 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.1470 http://www.cathdb.info/version/latest/superfamily/3.40.50.1470 GeneID 945765 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945765 HAMAP MF_00083 http://hamap.expasy.org/unirule/MF_00083 HOGENOM HOG000004796 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000004796&db=HOGENOM6 InParanoid P0A7D1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7D1 IntAct P0A7D1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7D1* IntEnz 3.1.1.29 {ECO:0000255|HAMAP-Rule:MF_00083} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.1.29 {ECO:0000255|HAMAP-Rule:MF_00083} InterPro IPR001328 http://www.ebi.ac.uk/interpro/entry/IPR001328 InterPro IPR018171 http://www.ebi.ac.uk/interpro/entry/IPR018171 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03012 http://www.genome.jp/dbget-bin/www_bget?ko03012 KEGG_Gene ecj:JW1195 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1195 KEGG_Gene eco:b1204 http://www.genome.jp/dbget-bin/www_bget?eco:b1204 KEGG_Orthology KO:K01056 http://www.genome.jp/dbget-bin/www_bget?KO:K01056 MINT MINT-1225563 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1225563 OMA RFYKILP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RFYKILP PANTHER PTHR17224 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR17224 PDB 2PTH http://www.ebi.ac.uk/pdbe-srv/view/entry/2PTH PDB 3VJR http://www.ebi.ac.uk/pdbe-srv/view/entry/3VJR PDBsum 2PTH http://www.ebi.ac.uk/pdbsum/2PTH PDBsum 3VJR http://www.ebi.ac.uk/pdbsum/3VJR PROSITE PS01195 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01195 PROSITE PS01196 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01196 PSORT swissprot:PTH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTH_ECOLI PSORT-B swissprot:PTH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTH_ECOLI PSORT2 swissprot:PTH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTH_ECOLI Pfam PF01195 http://pfam.xfam.org/family/PF01195 Phobius swissprot:PTH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTH_ECOLI PhylomeDB P0A7D1 http://phylomedb.org/?seqid=P0A7D1 ProteinModelPortal P0A7D1 http://www.proteinmodelportal.org/query/uniprot/P0A7D1 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1833189 http://www.ncbi.nlm.nih.gov/pubmed/1833189 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9144799 http://www.ncbi.nlm.nih.gov/pubmed/9144799 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9303320 http://www.ncbi.nlm.nih.gov/pubmed/9303320 RefSeq NP_415722 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415722 RefSeq WP_000152933 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000152933 SMR P0A7D1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7D1 STRING 511145.b1204 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1204&targetmode=cogs STRING COG0193 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0193&targetmode=cogs SUPFAM SSF53178 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53178 TIGRFAMs TIGR00447 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00447 UniProtKB PTH_ECOLI http://www.uniprot.org/uniprot/PTH_ECOLI UniProtKB-AC P0A7D1 http://www.uniprot.org/uniprot/P0A7D1 charge swissprot:PTH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTH_ECOLI eggNOG COG0193 http://eggnogapi.embl.de/nog_data/html/tree/COG0193 eggNOG ENOG4108ZPD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZPD epestfind swissprot:PTH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTH_ECOLI garnier swissprot:PTH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTH_ECOLI helixturnhelix swissprot:PTH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTH_ECOLI hmoment swissprot:PTH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTH_ECOLI iep swissprot:PTH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTH_ECOLI inforesidue swissprot:PTH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTH_ECOLI octanol swissprot:PTH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTH_ECOLI pepcoil swissprot:PTH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTH_ECOLI pepdigest swissprot:PTH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTH_ECOLI pepinfo swissprot:PTH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTH_ECOLI pepnet swissprot:PTH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTH_ECOLI pepstats swissprot:PTH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTH_ECOLI pepwheel swissprot:PTH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTH_ECOLI pepwindow swissprot:PTH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTH_ECOLI sigcleave swissprot:PTH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTH_ECOLI ## Database ID URL or Descriptions # AltName DnaJ-like protein DjlA {ECO 0000305} # BioGrid 4261616 7 # CDD cd06257 DnaJ # DOMAIN DJLA_ECOLI The transmembrane domain is a dimerization domain. {ECO 0000255|HAMAP-Rule MF_01153, ECO 0000269|PubMed 12655402}. # EcoGene EG11570 djlA # FUNCTION DJLA_ECOLI Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host. {ECO 0000255|HAMAP-Rule MF_01153, ECO 0000269|PubMed 11106641, ECO 0000269|PubMed 11758943, ECO 0000269|PubMed 9364917}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0051087 chaperone binding; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # Gene3D 1.10.287.110 -; 1. # Gene3D 1.10.3680.10 -; 1. # HAMAP MF_01153 DjlA # IntAct P31680 7 # InterPro IPR001623 DnaJ_domain # InterPro IPR007791 DjlA_N # InterPro IPR023749 DjlA # InterPro IPR029024 TerB-like # KEGG_Brite ko03110 Chaperones and folding catalysts # Organism DJLA_ECOLI Escherichia coli (strain K12) # PATRIC 32115209 VBIEscCol129921_0056 # PIR G64726 G64726 # PRINTS PR00625 JDOMAIN # PROSITE PS50076 DNAJ_2 # Pfam PF00226 DnaJ # Pfam PF05099 TerB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Co-chaperone protein DjlA {ECO:0000255|HAMAP-Rule MF_01153, ECO:0000305} # RefSeq NP_414597 NC_000913.3 # RefSeq WP_001200579 NZ_LN832404.1 # SIMILARITY Contains 1 J domain. {ECO:0000255|HAMAP- Rule MF_01153}. # SMART SM00271 DnaJ # SUBCELLULAR LOCATION DJLA_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01153, ECO 0000269|PubMed 11106641, ECO 0000269|PubMed 8809778, ECO 0000269|PubMed 9364917}; Single- pass type III membrane protein {ECO 0000255|HAMAP-Rule MF_01153, ECO 0000269|PubMed 11106641, ECO 0000269|PubMed 8809778, ECO 0000269|PubMed 9364917}. # SUBUNIT DJLA_ECOLI Homodimer. {ECO 0000255|HAMAP-Rule MF_01153, ECO 0000269|PubMed 12655402}. # SUPFAM SSF46565 SSF46565 # eggNOG COG1076 LUCA # eggNOG ENOG41066UG Bacteria BLAST swissprot:DJLA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DJLA_ECOLI BioCyc ECOL316407:JW0054-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0054-MONOMER BioCyc EcoCyc:EG11570-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11570-MONOMER COG COG1076 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1076 DOI 10.1007/s00239-002-2423-0 http://dx.doi.org/10.1007/s00239-002-2423-0 DOI 10.1007/s00438-002-0793-z http://dx.doi.org/10.1007/s00438-002-0793-z DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M003855200 http://dx.doi.org/10.1074/jbc.M003855200 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1111/j.1365-2958.1996.tb02646.x http://dx.doi.org/10.1111/j.1365-2958.1996.tb02646.x DOI 10.1111/j.1365-2958.1997.mmi527.x http://dx.doi.org/10.1111/j.1365-2958.1997.mmi527.x DOI 10.1111/j.1365-2958.1997.mmi528.x http://dx.doi.org/10.1111/j.1365-2958.1997.mmi528.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1271/bbb.65.2364 http://dx.doi.org/10.1271/bbb.65.2364 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL AY625119 http://www.ebi.ac.uk/ena/data/view/AY625119 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1530 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1530 EcoGene EG11570 http://www.ecogene.org/geneInfo.php?eg_id=EG11570 EnsemblBacteria AAC73166 http://www.ensemblgenomes.org/id/AAC73166 EnsemblBacteria AAC73166 http://www.ensemblgenomes.org/id/AAC73166 EnsemblBacteria BAB96623 http://www.ensemblgenomes.org/id/BAB96623 EnsemblBacteria BAB96623 http://www.ensemblgenomes.org/id/BAB96623 EnsemblBacteria BAB96623 http://www.ensemblgenomes.org/id/BAB96623 EnsemblBacteria b0055 http://www.ensemblgenomes.org/id/b0055 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0051087 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051087 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 Gene3D 1.10.287.110 http://www.cathdb.info/version/latest/superfamily/1.10.287.110 Gene3D 1.10.3680.10 http://www.cathdb.info/version/latest/superfamily/1.10.3680.10 GeneID 948992 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948992 HAMAP MF_01153 http://hamap.expasy.org/unirule/MF_01153 HOGENOM HOG000272779 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000272779&db=HOGENOM6 InParanoid P31680 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31680 IntAct P31680 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31680* InterPro IPR001623 http://www.ebi.ac.uk/interpro/entry/IPR001623 InterPro IPR007791 http://www.ebi.ac.uk/interpro/entry/IPR007791 InterPro IPR023749 http://www.ebi.ac.uk/interpro/entry/IPR023749 InterPro IPR029024 http://www.ebi.ac.uk/interpro/entry/IPR029024 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW0054 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0054 KEGG_Gene eco:b0055 http://www.genome.jp/dbget-bin/www_bget?eco:b0055 KEGG_Orthology KO:K05801 http://www.genome.jp/dbget-bin/www_bget?KO:K05801 OMA MQYWGKL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MQYWGKL PRINTS PR00625 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00625 PROSITE PS50076 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50076 PSORT swissprot:DJLA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DJLA_ECOLI PSORT-B swissprot:DJLA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DJLA_ECOLI PSORT2 swissprot:DJLA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DJLA_ECOLI Pfam PF00226 http://pfam.xfam.org/family/PF00226 Pfam PF05099 http://pfam.xfam.org/family/PF05099 Phobius swissprot:DJLA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DJLA_ECOLI ProteinModelPortal P31680 http://www.proteinmodelportal.org/query/uniprot/P31680 PubMed 11106641 http://www.ncbi.nlm.nih.gov/pubmed/11106641 PubMed 11758943 http://www.ncbi.nlm.nih.gov/pubmed/11758943 PubMed 12655402 http://www.ncbi.nlm.nih.gov/pubmed/12655402 PubMed 12664169 http://www.ncbi.nlm.nih.gov/pubmed/12664169 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8809778 http://www.ncbi.nlm.nih.gov/pubmed/8809778 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9364917 http://www.ncbi.nlm.nih.gov/pubmed/9364917 PubMed 9364918 http://www.ncbi.nlm.nih.gov/pubmed/9364918 RefSeq NP_414597 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414597 RefSeq WP_001200579 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001200579 SMART SM00271 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00271 SMR P31680 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31680 STRING 511145.b0055 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0055&targetmode=cogs STRING COG1076 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1076&targetmode=cogs SUPFAM SSF46565 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46565 UniProtKB DJLA_ECOLI http://www.uniprot.org/uniprot/DJLA_ECOLI UniProtKB-AC P31680 http://www.uniprot.org/uniprot/P31680 charge swissprot:DJLA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DJLA_ECOLI eggNOG COG1076 http://eggnogapi.embl.de/nog_data/html/tree/COG1076 eggNOG ENOG41066UG http://eggnogapi.embl.de/nog_data/html/tree/ENOG41066UG epestfind swissprot:DJLA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DJLA_ECOLI garnier swissprot:DJLA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DJLA_ECOLI helixturnhelix swissprot:DJLA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DJLA_ECOLI hmoment swissprot:DJLA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DJLA_ECOLI iep swissprot:DJLA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DJLA_ECOLI inforesidue swissprot:DJLA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DJLA_ECOLI octanol swissprot:DJLA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DJLA_ECOLI pepcoil swissprot:DJLA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DJLA_ECOLI pepdigest swissprot:DJLA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DJLA_ECOLI pepinfo swissprot:DJLA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DJLA_ECOLI pepnet swissprot:DJLA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DJLA_ECOLI pepstats swissprot:DJLA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DJLA_ECOLI pepwheel swissprot:DJLA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DJLA_ECOLI pepwindow swissprot:DJLA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DJLA_ECOLI sigcleave swissprot:DJLA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DJLA_ECOLI ## Database ID URL or Descriptions # AltName MUG_ECOLI Double-strand-specific uracil glycosylase # AltName MUG_ECOLI Mismatch-specific uracil DNA-glycosylase # BRENDA 3.2.2.28 2026 # BioGrid 4262387 156 # CATALYTIC ACTIVITY MUG_ECOLI Specifically hydrolyzes mismatched double- stranded DNA and polynucleotides, releasing free uracil. # CDD cd10028 UDG_F2_MUG # ENZYME REGULATION MUG_ECOLI Subject to strong product inhibition. N- glycosyl hydrolysis proceeds 100-fold faster than product release. # EcoGene EG12717 mug # FUNCTION MUG_ECOLI Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells. {ECO 0000269|PubMed 12668677, ECO 0000269|PubMed 8878487}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004844 uracil DNA N-glycosylase activity; IBA:GO_Central. # GO_function GO:0008263 pyrimidine-specific mismatch base pair DNA N-glycosylase activity; IDA:EcoCyc. # GO_process GO:0006285 base-excision repair, AP site formation; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_process GO:0006259 DNA metabolic process # Gene3D 3.40.470.10 -; 1. # HAMAP MF_01956 MUG # INDUCTION Induced in stationary phase. {ECO:0000269|PubMed 11555290}. # IntAct P0A9H1 21 # InterPro IPR005122 Uracil-DNA_glycosylase-like # InterPro IPR015637 MUG/TDG # InterPro IPR023502 MUG_bact # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko03410 Base excision repair # Organism MUG_ECOLI Escherichia coli (strain K12) # PANTHER PTHR12159 PTHR12159 # PATRIC 32121552 VBIEscCol129921_3163 # PDB 1MTL X-ray; 2.80 A; A/B=1-168 # PDB 1MUG X-ray; 1.80 A; A=1-168 # PDB 1MWI X-ray; 2.35 A; A=1-168 # PDB 1MWJ X-ray; 2.85 A; A=1-168 # PIR B65095 B65095 # Pfam PF03167 UDG # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MUG_ECOLI G/U mismatch-specific DNA glycosylase # RefSeq NP_417540 NC_000913.3 # RefSeq WP_000228937 NZ_LN832404.1 # SIMILARITY Belongs to the TDG/mug DNA glycosylase family. {ECO 0000305}. # SUBCELLULAR LOCATION MUG_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT MUG_ECOLI Binds DNA as a monomer. {ECO 0000269|PubMed 10581234, ECO 0000269|PubMed 9489705, ECO 0000269|PubMed 9699633}. # SUPFAM SSF52141 SSF52141 # eggNOG COG3663 LUCA # eggNOG ENOG4108VCA Bacteria BLAST swissprot:MUG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MUG_ECOLI BioCyc ECOL316407:JW3040-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3040-MONOMER BioCyc EcoCyc:EG12717-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12717-MONOMER BioCyc MetaCyc:EG12717-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12717-MONOMER COG COG3663 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3663 DOI 10.1016/S0092-8674(00)80904-6 http://dx.doi.org/10.1016/S0092-8674(00)80904-6 DOI 10.1038/1394 http://dx.doi.org/10.1038/1394 DOI 10.1038/383735a0 http://dx.doi.org/10.1038/383735a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2001.02559.x http://dx.doi.org/10.1046/j.1365-2958.2001.02559.x DOI 10.1074/jbc.M210860200 http://dx.doi.org/10.1074/jbc.M210860200 DOI 10.1093/emboj/18.23.6599 http://dx.doi.org/10.1093/emboj/18.23.6599 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1093/nar/9.12.2889 http://dx.doi.org/10.1093/nar/9.12.2889 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.2.2.28 http://www.genome.jp/dbget-bin/www_bget?EC:3.2.2.28 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01687 http://www.ebi.ac.uk/ena/data/view/J01687 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28379 http://www.ebi.ac.uk/ena/data/view/U28379 ENZYME 3.2.2.28 http://enzyme.expasy.org/EC/3.2.2.28 EchoBASE EB2576 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2576 EcoGene EG12717 http://www.ecogene.org/geneInfo.php?eg_id=EG12717 EnsemblBacteria AAC76104 http://www.ensemblgenomes.org/id/AAC76104 EnsemblBacteria AAC76104 http://www.ensemblgenomes.org/id/AAC76104 EnsemblBacteria BAE77119 http://www.ensemblgenomes.org/id/BAE77119 EnsemblBacteria BAE77119 http://www.ensemblgenomes.org/id/BAE77119 EnsemblBacteria BAE77119 http://www.ensemblgenomes.org/id/BAE77119 EnsemblBacteria b3068 http://www.ensemblgenomes.org/id/b3068 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004844 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004844 GO_function GO:0008263 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008263 GO_process GO:0006285 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006285 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 Gene3D 3.40.470.10 http://www.cathdb.info/version/latest/superfamily/3.40.470.10 GeneID 947560 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947560 HAMAP MF_01956 http://hamap.expasy.org/unirule/MF_01956 HOGENOM HOG000264684 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000264684&db=HOGENOM6 InParanoid P0A9H1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9H1 IntAct P0A9H1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9H1* IntEnz 3.2.2.28 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.2.2.28 InterPro IPR005122 http://www.ebi.ac.uk/interpro/entry/IPR005122 InterPro IPR015637 http://www.ebi.ac.uk/interpro/entry/IPR015637 InterPro IPR023502 http://www.ebi.ac.uk/interpro/entry/IPR023502 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW3040 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3040 KEGG_Gene eco:b3068 http://www.genome.jp/dbget-bin/www_bget?eco:b3068 KEGG_Orthology KO:K03649 http://www.genome.jp/dbget-bin/www_bget?KO:K03649 KEGG_Pathway ko03410 http://www.genome.jp/kegg-bin/show_pathway?ko03410 OMA RFWRVLH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RFWRVLH PANTHER PTHR12159 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12159 PDB 1MTL http://www.ebi.ac.uk/pdbe-srv/view/entry/1MTL PDB 1MUG http://www.ebi.ac.uk/pdbe-srv/view/entry/1MUG PDB 1MWI http://www.ebi.ac.uk/pdbe-srv/view/entry/1MWI PDB 1MWJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1MWJ PDBsum 1MTL http://www.ebi.ac.uk/pdbsum/1MTL PDBsum 1MUG http://www.ebi.ac.uk/pdbsum/1MUG PDBsum 1MWI http://www.ebi.ac.uk/pdbsum/1MWI PDBsum 1MWJ http://www.ebi.ac.uk/pdbsum/1MWJ PSORT swissprot:MUG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MUG_ECOLI PSORT-B swissprot:MUG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MUG_ECOLI PSORT2 swissprot:MUG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MUG_ECOLI Pfam PF03167 http://pfam.xfam.org/family/PF03167 Phobius swissprot:MUG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MUG_ECOLI PhylomeDB P0A9H1 http://phylomedb.org/?seqid=P0A9H1 ProteinModelPortal P0A9H1 http://www.proteinmodelportal.org/query/uniprot/P0A9H1 PubMed 10581234 http://www.ncbi.nlm.nih.gov/pubmed/10581234 PubMed 11555290 http://www.ncbi.nlm.nih.gov/pubmed/11555290 PubMed 12668677 http://www.ncbi.nlm.nih.gov/pubmed/12668677 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6269063 http://www.ncbi.nlm.nih.gov/pubmed/6269063 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 8878487 http://www.ncbi.nlm.nih.gov/pubmed/8878487 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9489705 http://www.ncbi.nlm.nih.gov/pubmed/9489705 PubMed 9699633 http://www.ncbi.nlm.nih.gov/pubmed/9699633 RefSeq NP_417540 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417540 RefSeq WP_000228937 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000228937 SMR P0A9H1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9H1 STRING 511145.b3068 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3068&targetmode=cogs STRING COG3663 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3663&targetmode=cogs SUPFAM SSF52141 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52141 UniProtKB MUG_ECOLI http://www.uniprot.org/uniprot/MUG_ECOLI UniProtKB-AC P0A9H1 http://www.uniprot.org/uniprot/P0A9H1 charge swissprot:MUG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MUG_ECOLI eggNOG COG3663 http://eggnogapi.embl.de/nog_data/html/tree/COG3663 eggNOG ENOG4108VCA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108VCA epestfind swissprot:MUG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MUG_ECOLI garnier swissprot:MUG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MUG_ECOLI helixturnhelix swissprot:MUG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MUG_ECOLI hmoment swissprot:MUG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MUG_ECOLI iep swissprot:MUG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MUG_ECOLI inforesidue swissprot:MUG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MUG_ECOLI octanol swissprot:MUG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MUG_ECOLI pepcoil swissprot:MUG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MUG_ECOLI pepdigest swissprot:MUG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MUG_ECOLI pepinfo swissprot:MUG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MUG_ECOLI pepnet swissprot:MUG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MUG_ECOLI pepstats swissprot:MUG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MUG_ECOLI pepwheel swissprot:MUG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MUG_ECOLI pepwindow swissprot:MUG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MUG_ECOLI sigcleave swissprot:MUG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MUG_ECOLI ## Database ID URL or Descriptions # BioGrid 4261139 17 # CDD cd10466 FimH_man-bind # EcoGene EG13799 ydeQ # GO_component GO:0009289 pilus; IEA:UniProtKB-SubCell. # GO_process GO:0007155 cell adhesion; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0007155 cell adhesion # Gene3D 2.60.40.1090 -; 2. # InterPro IPR000259 Adhesion_dom_fimbrial # InterPro IPR008966 Adhesion_dom # InterPro IPR015243 FimH_man-bd # Organism YDEQ_ECOLI Escherichia coli (strain K12) # PATRIC 32118298 VBIEscCol129921_1569 # PIR A64904 A64904 # Pfam PF09160 FimH_man-bind # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDEQ_ECOLI Uncharacterized fimbrial-like protein YdeQ # RefSeq NP_416019 NC_000913.3 # RefSeq WP_000520676 NZ_LN832404.1 # SIMILARITY Belongs to the fimbrial protein family. {ECO 0000305}. # SUBCELLULAR LOCATION YDEQ_ECOLI Fimbrium {ECO 0000305}. # SUPFAM SSF49401 SSF49401; 2 # eggNOG ENOG4106PIH Bacteria # eggNOG ENOG410YESZ LUCA BLAST swissprot:YDEQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDEQ_ECOLI BioCyc ECOL316407:JW1496-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1496-MONOMER BioCyc EcoCyc:G6792-MONOMER http://biocyc.org/getid?id=EcoCyc:G6792-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3560 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3560 EcoGene EG13799 http://www.ecogene.org/geneInfo.php?eg_id=EG13799 EnsemblBacteria AAC74575 http://www.ensemblgenomes.org/id/AAC74575 EnsemblBacteria AAC74575 http://www.ensemblgenomes.org/id/AAC74575 EnsemblBacteria BAA15175 http://www.ensemblgenomes.org/id/BAA15175 EnsemblBacteria BAA15175 http://www.ensemblgenomes.org/id/BAA15175 EnsemblBacteria BAA15175 http://www.ensemblgenomes.org/id/BAA15175 EnsemblBacteria b1502 http://www.ensemblgenomes.org/id/b1502 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009289 GO_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 Gene3D 2.60.40.1090 http://www.cathdb.info/version/latest/superfamily/2.60.40.1090 GeneID 946050 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946050 HOGENOM HOG000120719 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120719&db=HOGENOM6 InterPro IPR000259 http://www.ebi.ac.uk/interpro/entry/IPR000259 InterPro IPR008966 http://www.ebi.ac.uk/interpro/entry/IPR008966 InterPro IPR015243 http://www.ebi.ac.uk/interpro/entry/IPR015243 KEGG_Gene ecj:JW1496 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1496 KEGG_Gene eco:b1502 http://www.genome.jp/dbget-bin/www_bget?eco:b1502 OMA MSQHISC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MSQHISC PSORT swissprot:YDEQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDEQ_ECOLI PSORT-B swissprot:YDEQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDEQ_ECOLI PSORT2 swissprot:YDEQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDEQ_ECOLI Pfam PF09160 http://pfam.xfam.org/family/PF09160 Phobius swissprot:YDEQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDEQ_ECOLI ProteinModelPortal P77588 http://www.proteinmodelportal.org/query/uniprot/P77588 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416019 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416019 RefSeq WP_000520676 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000520676 SMR P77588 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77588 STRING 511145.b1502 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1502&targetmode=cogs SUPFAM SSF49401 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49401 UniProtKB YDEQ_ECOLI http://www.uniprot.org/uniprot/YDEQ_ECOLI UniProtKB-AC P77588 http://www.uniprot.org/uniprot/P77588 charge swissprot:YDEQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDEQ_ECOLI eggNOG ENOG4106PIH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106PIH eggNOG ENOG410YESZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YESZ epestfind swissprot:YDEQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDEQ_ECOLI garnier swissprot:YDEQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDEQ_ECOLI helixturnhelix swissprot:YDEQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDEQ_ECOLI hmoment swissprot:YDEQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDEQ_ECOLI iep swissprot:YDEQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDEQ_ECOLI inforesidue swissprot:YDEQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDEQ_ECOLI octanol swissprot:YDEQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDEQ_ECOLI pepcoil swissprot:YDEQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDEQ_ECOLI pepdigest swissprot:YDEQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDEQ_ECOLI pepinfo swissprot:YDEQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDEQ_ECOLI pepnet swissprot:YDEQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDEQ_ECOLI pepstats swissprot:YDEQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDEQ_ECOLI pepwheel swissprot:YDEQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDEQ_ECOLI pepwindow swissprot:YDEQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDEQ_ECOLI sigcleave swissprot:YDEQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDEQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4261966 170 # EcoGene EG10834 recR # FUNCTION RECR_ECOLI May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0000731 DNA synthesis involved in DNA repair; IMP:EcoliWiki. # GO_process GO:0006310 DNA recombination; IEA:UniProtKB-HAMAP. # GO_process GO:0009411 response to UV; IMP:EcoliWiki. # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.140 -; 1. # HAMAP MF_00017 RecR # IntAct P0A7H6 5 # InterPro IPR000093 DNA_Rcmb_RecR # InterPro IPR006171 Toprim_domain # InterPro IPR015967 Rcmb_RecR_CS # InterPro IPR023627 Rcmb_RecR # InterPro IPR023628 Rcmb_RecR_C4-type_Zn # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko03440 Homologous recombination # Organism RECR_ECOLI Escherichia coli (strain K12) # PATRIC 32116101 VBIEscCol129921_0492 # PIR JU0106 BVECRR # PROSITE PS01300 RECR # PROSITE PS50880 TOPRIM # Pfam PF02132 RecR # Pfam PF13662 Toprim_4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Recombination protein RecR {ECO:0000255|HAMAP-Rule MF_00017} # RefSeq NP_415005 NC_000913.3 # RefSeq WP_001195025 NZ_LN832404.1 # SIMILARITY Belongs to the RecR family. {ECO:0000255|HAMAP- Rule MF_00017}. # SIMILARITY Contains 1 Toprim domain. {ECO:0000255|HAMAP- Rule MF_00017}. # SMART SM00493 TOPRIM # SUPFAM SSF111304 SSF111304 # TIGRFAMs TIGR00615 recR # eggNOG COG0353 LUCA # eggNOG ENOG4105F3K Bacteria BLAST swissprot:RECR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RECR_ECOLI BioCyc ECOL316407:JW0461-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0461-MONOMER BioCyc EcoCyc:EG10834-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10834-MONOMER BioCyc MetaCyc:EG10834-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10834-MONOMER COG COG0353 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0353 DIP DIP-341N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-341N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/17.17.6781 http://dx.doi.org/10.1093/nar/17.17.6781 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M38777 http://www.ebi.ac.uk/ena/data/view/M38777 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL X15761 http://www.ebi.ac.uk/ena/data/view/X15761 EchoBASE EB0827 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0827 EcoGene EG10834 http://www.ecogene.org/geneInfo.php?eg_id=EG10834 EnsemblBacteria AAC73574 http://www.ensemblgenomes.org/id/AAC73574 EnsemblBacteria AAC73574 http://www.ensemblgenomes.org/id/AAC73574 EnsemblBacteria BAE76251 http://www.ensemblgenomes.org/id/BAE76251 EnsemblBacteria BAE76251 http://www.ensemblgenomes.org/id/BAE76251 EnsemblBacteria BAE76251 http://www.ensemblgenomes.org/id/BAE76251 EnsemblBacteria b0472 http://www.ensemblgenomes.org/id/b0472 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0000731 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000731 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0009411 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009411 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.140 http://www.cathdb.info/version/latest/superfamily/3.40.50.140 GeneID 945100 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945100 HAMAP MF_00017 http://hamap.expasy.org/unirule/MF_00017 HOGENOM HOG000103272 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000103272&db=HOGENOM6 InParanoid P0A7H6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7H6 IntAct P0A7H6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7H6* InterPro IPR000093 http://www.ebi.ac.uk/interpro/entry/IPR000093 InterPro IPR006171 http://www.ebi.ac.uk/interpro/entry/IPR006171 InterPro IPR015967 http://www.ebi.ac.uk/interpro/entry/IPR015967 InterPro IPR023627 http://www.ebi.ac.uk/interpro/entry/IPR023627 InterPro IPR023628 http://www.ebi.ac.uk/interpro/entry/IPR023628 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW0461 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0461 KEGG_Gene eco:b0472 http://www.genome.jp/dbget-bin/www_bget?eco:b0472 KEGG_Orthology KO:K06187 http://www.genome.jp/dbget-bin/www_bget?KO:K06187 KEGG_Pathway ko03440 http://www.genome.jp/kegg-bin/show_pathway?ko03440 OMA DVMAIEN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DVMAIEN PROSITE PS01300 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01300 PROSITE PS50880 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50880 PSORT swissprot:RECR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RECR_ECOLI PSORT-B swissprot:RECR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RECR_ECOLI PSORT2 swissprot:RECR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RECR_ECOLI Pfam PF02132 http://pfam.xfam.org/family/PF02132 Pfam PF13662 http://pfam.xfam.org/family/PF13662 Phobius swissprot:RECR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RECR_ECOLI PhylomeDB P0A7H6 http://phylomedb.org/?seqid=P0A7H6 ProteinModelPortal P0A7H6 http://www.proteinmodelportal.org/query/uniprot/P0A7H6 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1698765 http://www.ncbi.nlm.nih.gov/pubmed/1698765 PubMed 2674903 http://www.ncbi.nlm.nih.gov/pubmed/2674903 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415005 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415005 RefSeq WP_001195025 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001195025 SMART SM00493 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00493 SMR P0A7H6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7H6 STRING 511145.b0472 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0472&targetmode=cogs STRING COG0353 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0353&targetmode=cogs SUPFAM SSF111304 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF111304 TIGRFAMs TIGR00615 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00615 UniProtKB RECR_ECOLI http://www.uniprot.org/uniprot/RECR_ECOLI UniProtKB-AC P0A7H6 http://www.uniprot.org/uniprot/P0A7H6 charge swissprot:RECR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RECR_ECOLI eggNOG COG0353 http://eggnogapi.embl.de/nog_data/html/tree/COG0353 eggNOG ENOG4105F3K http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F3K epestfind swissprot:RECR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RECR_ECOLI garnier swissprot:RECR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RECR_ECOLI helixturnhelix swissprot:RECR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RECR_ECOLI hmoment swissprot:RECR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RECR_ECOLI iep swissprot:RECR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RECR_ECOLI inforesidue swissprot:RECR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RECR_ECOLI octanol swissprot:RECR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RECR_ECOLI pepcoil swissprot:RECR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RECR_ECOLI pepdigest swissprot:RECR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RECR_ECOLI pepinfo swissprot:RECR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RECR_ECOLI pepnet swissprot:RECR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RECR_ECOLI pepstats swissprot:RECR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RECR_ECOLI pepwheel swissprot:RECR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RECR_ECOLI pepwindow swissprot:RECR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RECR_ECOLI sigcleave swissprot:RECR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RECR_ECOLI ## Database ID URL or Descriptions # BioGrid 4263026 7 # DISRUPTION PHENOTYPE Deletion causes manganese sensitivity and leads to increased intracellular manganese levels. {ECO:0000269|PubMed 21908668}. # EcoGene EG14012 mntP # FUNCTION MNTP_ECOLI Probably functions as a manganese efflux pump. {ECO 0000255|HAMAP-Rule MF_01521, ECO 0000269|PubMed 21908668}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005384 manganese ion transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0010042 response to manganese ion; IEP:EcoCyc. # GO_process GO:0071421 manganese ion transmembrane transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0055085 transmembrane transport # HAMAP MF_01521 MntP_pump # INDUCTION Up-regulated by MntR in response to manganese. {ECO:0000269|PubMed 21908668}. # InterPro IPR003810 Mntp/YtaF # InterPro IPR022929 Put_MntP # Organism MNTP_ECOLI Escherichia coli (strain K12) # PATRIC 32118961 VBIEscCol129921_1898 # PIR E64943 E64943 # Pfam PF02659 Mntp # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Probable manganese efflux pump MntP {ECO:0000255|HAMAP-Rule MF_01521} # RefSeq NP_416335 NC_000913.3 # RefSeq WP_001296134 NZ_LN832404.1 # SIMILARITY Belongs to the MntP (TC 9.B.29) family. {ECO:0000255|HAMAP-Rule MF_01521}. # SUBCELLULAR LOCATION MNTP_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.107.1 the mntp mn2+ exporter (mntp) family # eggNOG COG1971 LUCA # eggNOG ENOG4108UI1 Bacteria BLAST swissprot:MNTP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MNTP_ECOLI BioCyc ECOL316407:JW5830-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5830-MONOMER BioCyc EcoCyc:G6999-MONOMER http://biocyc.org/getid?id=EcoCyc:G6999-MONOMER BioCyc MetaCyc:G6999-MONOMER http://biocyc.org/getid?id=MetaCyc:G6999-MONOMER DOI 10.1006/jmbi.1994.1163 http://dx.doi.org/10.1006/jmbi.1994.1163 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.05872-11 http://dx.doi.org/10.1128/JB.05872-11 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X75948 http://www.ebi.ac.uk/ena/data/view/X75948 EchoBASE EB3768 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3768 EcoGene EG14012 http://www.ecogene.org/geneInfo.php?eg_id=EG14012 EnsemblBacteria AAC74891 http://www.ensemblgenomes.org/id/AAC74891 EnsemblBacteria AAC74891 http://www.ensemblgenomes.org/id/AAC74891 EnsemblBacteria BAA15632 http://www.ensemblgenomes.org/id/BAA15632 EnsemblBacteria BAA15632 http://www.ensemblgenomes.org/id/BAA15632 EnsemblBacteria BAA15632 http://www.ensemblgenomes.org/id/BAA15632 EnsemblBacteria b1821 http://www.ensemblgenomes.org/id/b1821 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005384 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005384 GO_process GO:0010042 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010042 GO_process GO:0071421 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071421 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 946341 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946341 HAMAP MF_01521 http://hamap.expasy.org/unirule/MF_01521 HOGENOM HOG000238852 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000238852&db=HOGENOM6 InParanoid P76264 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76264 InterPro IPR003810 http://www.ebi.ac.uk/interpro/entry/IPR003810 InterPro IPR022929 http://www.ebi.ac.uk/interpro/entry/IPR022929 KEGG_Gene ecj:JW5830 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5830 KEGG_Gene eco:b1821 http://www.genome.jp/dbget-bin/www_bget?eco:b1821 OMA FIGGKMI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FIGGKMI PSORT swissprot:MNTP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MNTP_ECOLI PSORT-B swissprot:MNTP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MNTP_ECOLI PSORT2 swissprot:MNTP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MNTP_ECOLI Pfam PF02659 http://pfam.xfam.org/family/PF02659 Phobius swissprot:MNTP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MNTP_ECOLI PhylomeDB P76264 http://phylomedb.org/?seqid=P76264 ProteinModelPortal P76264 http://www.proteinmodelportal.org/query/uniprot/P76264 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21908668 http://www.ncbi.nlm.nih.gov/pubmed/21908668 PubMed 8107138 http://www.ncbi.nlm.nih.gov/pubmed/8107138 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416335 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416335 RefSeq WP_001296134 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001296134 STRING 511145.b1821 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1821&targetmode=cogs TCDB 2.A.107.1 http://www.tcdb.org/search/result.php?tc=2.A.107.1 UniProtKB MNTP_ECOLI http://www.uniprot.org/uniprot/MNTP_ECOLI UniProtKB-AC P76264 http://www.uniprot.org/uniprot/P76264 charge swissprot:MNTP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MNTP_ECOLI eggNOG COG1971 http://eggnogapi.embl.de/nog_data/html/tree/COG1971 eggNOG ENOG4108UI1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UI1 epestfind swissprot:MNTP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MNTP_ECOLI garnier swissprot:MNTP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MNTP_ECOLI helixturnhelix swissprot:MNTP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MNTP_ECOLI hmoment swissprot:MNTP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MNTP_ECOLI iep swissprot:MNTP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MNTP_ECOLI inforesidue swissprot:MNTP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MNTP_ECOLI octanol swissprot:MNTP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MNTP_ECOLI pepcoil swissprot:MNTP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MNTP_ECOLI pepdigest swissprot:MNTP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MNTP_ECOLI pepinfo swissprot:MNTP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MNTP_ECOLI pepnet swissprot:MNTP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MNTP_ECOLI pepstats swissprot:MNTP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MNTP_ECOLI pepwheel swissprot:MNTP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MNTP_ECOLI pepwindow swissprot:MNTP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MNTP_ECOLI sigcleave swissprot:MNTP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MNTP_ECOLI ## Database ID URL or Descriptions # BioGrid 4260864 148 # EcoGene EG14041 yedR # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # Organism YEDR_ECOLI Escherichia coli (strain K12) # PATRIC 32119255 VBIEscCol129921_2042 # PIR G64960 G64960 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEDR_ECOLI Inner membrane protein YedR # RefSeq NP_416472 NC_000913.3 # SUBCELLULAR LOCATION YEDR_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG ENOG4105Y0K Bacteria # eggNOG ENOG411246N LUCA BLAST swissprot:YEDR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEDR_ECOLI BioCyc ECOL316407:JW1946-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1946-MONOMER BioCyc EcoCyc:G7051-MONOMER http://biocyc.org/getid?id=EcoCyc:G7051-MONOMER DIP DIP-11849N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11849N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3795 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3795 EcoGene EG14041 http://www.ecogene.org/geneInfo.php?eg_id=EG14041 EnsemblBacteria AAC75029 http://www.ensemblgenomes.org/id/AAC75029 EnsemblBacteria AAC75029 http://www.ensemblgenomes.org/id/AAC75029 EnsemblBacteria BAE76557 http://www.ensemblgenomes.org/id/BAE76557 EnsemblBacteria BAE76557 http://www.ensemblgenomes.org/id/BAE76557 EnsemblBacteria BAE76557 http://www.ensemblgenomes.org/id/BAE76557 EnsemblBacteria b1963 http://www.ensemblgenomes.org/id/b1963 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 946477 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946477 HOGENOM HOG000121354 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000121354&db=HOGENOM6 IntAct P76334 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76334* KEGG_Gene ecj:JW1946 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1946 KEGG_Gene eco:b1963 http://www.genome.jp/dbget-bin/www_bget?eco:b1963 OMA FYAFCGY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FYAFCGY PSORT swissprot:YEDR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEDR_ECOLI PSORT-B swissprot:YEDR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEDR_ECOLI PSORT2 swissprot:YEDR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEDR_ECOLI Phobius swissprot:YEDR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEDR_ECOLI ProteinModelPortal P76334 http://www.proteinmodelportal.org/query/uniprot/P76334 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416472 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416472 STRING 511145.b1963 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1963&targetmode=cogs UniProtKB YEDR_ECOLI http://www.uniprot.org/uniprot/YEDR_ECOLI UniProtKB-AC P76334 http://www.uniprot.org/uniprot/P76334 charge swissprot:YEDR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEDR_ECOLI eggNOG ENOG4105Y0K http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105Y0K eggNOG ENOG411246N http://eggnogapi.embl.de/nog_data/html/tree/ENOG411246N epestfind swissprot:YEDR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEDR_ECOLI garnier swissprot:YEDR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEDR_ECOLI helixturnhelix swissprot:YEDR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEDR_ECOLI hmoment swissprot:YEDR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEDR_ECOLI iep swissprot:YEDR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEDR_ECOLI inforesidue swissprot:YEDR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEDR_ECOLI octanol swissprot:YEDR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEDR_ECOLI pepcoil swissprot:YEDR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEDR_ECOLI pepdigest swissprot:YEDR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEDR_ECOLI pepinfo swissprot:YEDR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEDR_ECOLI pepnet swissprot:YEDR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEDR_ECOLI pepstats swissprot:YEDR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEDR_ECOLI pepwheel swissprot:YEDR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEDR_ECOLI pepwindow swissprot:YEDR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEDR_ECOLI sigcleave swissprot:YEDR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEDR_ECOLI ## Database ID URL or Descriptions # AltName OMPC_ECOLI Outer membrane protein 1B # AltName OMPC_ECOLI Porin OmpC # BioGrid 4261917 276 # DOMAIN OMPC_ECOLI Loop L3 (residues 116-133) extends along the inner side of the beta barrel wall and may constrict the pore mid-length. {ECO 0000269|PubMed 16949612}. # EcoGene EG10670 ompC # FUNCTION OMPC_ECOLI Forms pores that allow passive diffusion of small molecules across the outer membrane. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_component GO:0045203 integral component of cell outer membrane; IDA:EcoliWiki. # GO_component GO:0046930 pore complex; IEA:UniProtKB-KW. # GO_function GO:0015288 porin activity; IEA:UniProtKB-KW. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006811 ion transport; IEA:UniProtKB-KW. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043234 protein complex # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # GOslim_process GO:0006950 response to stress # Gene3D 2.40.160.10 -; 1. # IntAct P06996 8 # InterPro IPR001702 Porin_Gram-ve # InterPro IPR001897 Porin_gammaproteobac # InterPro IPR013793 Porin_Gram-ve_CS # InterPro IPR023614 Porin_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02020 Two-component system # MISCELLANEOUS OMPC_ECOLI Binds 1 Mg(2+) per subunit; could be Ca(2+) in vivo. # Organism OMPC_ECOLI Escherichia coli (strain K12) # PATRIC 32119789 VBIEscCol129921_2304 # PDB 2J1N X-ray; 2.00 A; A/B/C=22-367 # PDB 2J4U X-ray; 2.99 A; P/Q/R/U/V/W=22-367 # PDB 2ZLE EM; 28.00 A; D=22-367 # PDB 3NB3 EM; -; D=22-367 # PDB 4A8D EM; 28.00 A; M=22-366 # PIR A20867 MMECPC # PRINTS PR00182 ECOLNEIPORIN # PRINTS PR00183 ECOLIPORIN # PROSITE PS00576 GRAM_NEG_PORIN # Pfam PF00267 Porin_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName OMPC_ECOLI Outer membrane protein C # RefSeq NP_416719 NC_000913.3 # RefSeq WP_000865568 NZ_LN832404.1 # SIMILARITY Belongs to the Gram-negative porin family. {ECO 0000305}. # SUBCELLULAR LOCATION OMPC_ECOLI Cell outer membrane; Multi-pass membrane protein. # SUBUNIT Homotrimer. {ECO:0000269|PubMed 16949612}. # TCDB 1.B.1.1 the general bacterial porin (gbp) family # eggNOG COG3203 LUCA # eggNOG ENOG4105FCK Bacteria BLAST swissprot:OMPC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:OMPC_ECOLI BioCyc ECOL316407:JW2203-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2203-MONOMER BioCyc EcoCyc:EG10670-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10670-MONOMER BioCyc MetaCyc:EG10670-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10670-MONOMER COG COG3203 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3203 DIP DIP-10397N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10397N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1002/elps.1150190539 http://dx.doi.org/10.1002/elps.1150190539 DOI 10.1016/0014-5793(83)80364-0 http://dx.doi.org/10.1016/0014-5793(83)80364-0 DOI 10.1016/j.jmb.2006.08.002 http://dx.doi.org/10.1016/j.jmb.2006.08.002 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K00541 http://www.ebi.ac.uk/ena/data/view/K00541 EMBL U00008 http://www.ebi.ac.uk/ena/data/view/U00008 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0664 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0664 EcoGene EG10670 http://www.ecogene.org/geneInfo.php?eg_id=EG10670 EnsemblBacteria AAC75275 http://www.ensemblgenomes.org/id/AAC75275 EnsemblBacteria AAC75275 http://www.ensemblgenomes.org/id/AAC75275 EnsemblBacteria BAA15998 http://www.ensemblgenomes.org/id/BAA15998 EnsemblBacteria BAA15998 http://www.ensemblgenomes.org/id/BAA15998 EnsemblBacteria BAA15998 http://www.ensemblgenomes.org/id/BAA15998 EnsemblBacteria b2215 http://www.ensemblgenomes.org/id/b2215 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0045203 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045203 GO_component GO:0046930 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046930 GO_function GO:0015288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015288 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006811 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 2.40.160.10 http://www.cathdb.info/version/latest/superfamily/2.40.160.10 GeneID 946716 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946716 HOGENOM HOG000272406 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000272406&db=HOGENOM6 InParanoid P06996 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P06996 IntAct P06996 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P06996* InterPro IPR001702 http://www.ebi.ac.uk/interpro/entry/IPR001702 InterPro IPR001897 http://www.ebi.ac.uk/interpro/entry/IPR001897 InterPro IPR013793 http://www.ebi.ac.uk/interpro/entry/IPR013793 InterPro IPR023614 http://www.ebi.ac.uk/interpro/entry/IPR023614 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2203 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2203 KEGG_Gene eco:b2215 http://www.genome.jp/dbget-bin/www_bget?eco:b2215 KEGG_Orthology KO:K09475 http://www.genome.jp/dbget-bin/www_bget?KO:K09475 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 MINT MINT-1248362 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1248362 OMA RTDEQNN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RTDEQNN PDB 2J1N http://www.ebi.ac.uk/pdbe-srv/view/entry/2J1N PDB 2J4U http://www.ebi.ac.uk/pdbe-srv/view/entry/2J4U PDB 2ZLE http://www.ebi.ac.uk/pdbe-srv/view/entry/2ZLE PDB 3NB3 http://www.ebi.ac.uk/pdbe-srv/view/entry/3NB3 PDB 4A8D http://www.ebi.ac.uk/pdbe-srv/view/entry/4A8D PDBsum 2J1N http://www.ebi.ac.uk/pdbsum/2J1N PDBsum 2J4U http://www.ebi.ac.uk/pdbsum/2J4U PDBsum 2ZLE http://www.ebi.ac.uk/pdbsum/2ZLE PDBsum 3NB3 http://www.ebi.ac.uk/pdbsum/3NB3 PDBsum 4A8D http://www.ebi.ac.uk/pdbsum/4A8D PRINTS PR00182 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00182 PRINTS PR00183 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00183 PROSITE PS00576 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00576 PSORT swissprot:OMPC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:OMPC_ECOLI PSORT-B swissprot:OMPC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:OMPC_ECOLI PSORT2 swissprot:OMPC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:OMPC_ECOLI Pfam PF00267 http://pfam.xfam.org/family/PF00267 Phobius swissprot:OMPC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:OMPC_ECOLI PhylomeDB P06996 http://phylomedb.org/?seqid=P06996 ProteinModelPortal P06996 http://www.proteinmodelportal.org/query/uniprot/P06996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16949612 http://www.ncbi.nlm.nih.gov/pubmed/16949612 PubMed 2997131 http://www.ncbi.nlm.nih.gov/pubmed/2997131 PubMed 6297988 http://www.ncbi.nlm.nih.gov/pubmed/6297988 PubMed 6304064 http://www.ncbi.nlm.nih.gov/pubmed/6304064 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9629924 http://www.ncbi.nlm.nih.gov/pubmed/9629924 RefSeq NP_416719 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416719 RefSeq WP_000865568 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000865568 SMR P06996 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P06996 STRING 511145.b2215 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2215&targetmode=cogs STRING COG3203 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3203&targetmode=cogs TCDB 1.B.1.1 http://www.tcdb.org/search/result.php?tc=1.B.1.1 UniProtKB OMPC_ECOLI http://www.uniprot.org/uniprot/OMPC_ECOLI UniProtKB-AC P06996 http://www.uniprot.org/uniprot/P06996 charge swissprot:OMPC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:OMPC_ECOLI eggNOG COG3203 http://eggnogapi.embl.de/nog_data/html/tree/COG3203 eggNOG ENOG4105FCK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FCK epestfind swissprot:OMPC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:OMPC_ECOLI garnier swissprot:OMPC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:OMPC_ECOLI helixturnhelix swissprot:OMPC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:OMPC_ECOLI hmoment swissprot:OMPC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:OMPC_ECOLI iep swissprot:OMPC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:OMPC_ECOLI inforesidue swissprot:OMPC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:OMPC_ECOLI octanol swissprot:OMPC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:OMPC_ECOLI pepcoil swissprot:OMPC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:OMPC_ECOLI pepdigest swissprot:OMPC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:OMPC_ECOLI pepinfo swissprot:OMPC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:OMPC_ECOLI pepnet swissprot:OMPC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:OMPC_ECOLI pepstats swissprot:OMPC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:OMPC_ECOLI pepwheel swissprot:OMPC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:OMPC_ECOLI pepwindow swissprot:OMPC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:OMPC_ECOLI sigcleave swissprot:OMPC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:OMPC_ECOLI ## Database ID URL or Descriptions # BioGrid 4261422 6 # EcoGene EG11287 ygbA # IntAct P25728 5 # InterPro IPR020483 Uncharacterised_YgbA # Organism YGBA_ECOLI Escherichia coli (strain K12) # PATRIC 32120864 VBIEscCol129921_2824 # PIR H65053 H65053 # Pfam PF11756 YgbA_NO # ProDom PD075772 Uncharacterised_YgbA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGBA_ECOLI Uncharacterized protein YgbA # RefSeq NP_417212 NC_000913.3 # RefSeq WP_000015497 NZ_LN832404.1 # eggNOG ENOG4105VXR Bacteria # eggNOG ENOG41121K2 LUCA BLAST swissprot:YGBA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGBA_ECOLI BioCyc ECOL316407:JW2702-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2702-MONOMER BioCyc EcoCyc:EG11287-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11287-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M64730 http://www.ebi.ac.uk/ena/data/view/M64730 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EchoBASE EB1264 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1264 EcoGene EG11287 http://www.ecogene.org/geneInfo.php?eg_id=EG11287 EnsemblBacteria AAC75774 http://www.ensemblgenomes.org/id/AAC75774 EnsemblBacteria AAC75774 http://www.ensemblgenomes.org/id/AAC75774 EnsemblBacteria BAE76809 http://www.ensemblgenomes.org/id/BAE76809 EnsemblBacteria BAE76809 http://www.ensemblgenomes.org/id/BAE76809 EnsemblBacteria BAE76809 http://www.ensemblgenomes.org/id/BAE76809 EnsemblBacteria b2732 http://www.ensemblgenomes.org/id/b2732 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947187 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947187 HOGENOM HOG000271460 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000271460&db=HOGENOM6 InParanoid P25728 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P25728 IntAct P25728 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P25728* InterPro IPR020483 http://www.ebi.ac.uk/interpro/entry/IPR020483 KEGG_Gene ecj:JW2702 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2702 KEGG_Gene eco:b2732 http://www.genome.jp/dbget-bin/www_bget?eco:b2732 OMA LTIRHLI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LTIRHLI PSORT swissprot:YGBA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGBA_ECOLI PSORT-B swissprot:YGBA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGBA_ECOLI PSORT2 swissprot:YGBA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGBA_ECOLI Pfam PF11756 http://pfam.xfam.org/family/PF11756 Phobius swissprot:YGBA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGBA_ECOLI ProteinModelPortal P25728 http://www.proteinmodelportal.org/query/uniprot/P25728 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1938937 http://www.ncbi.nlm.nih.gov/pubmed/1938937 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417212 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417212 RefSeq WP_000015497 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000015497 STRING 511145.b2732 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2732&targetmode=cogs UniProtKB YGBA_ECOLI http://www.uniprot.org/uniprot/YGBA_ECOLI UniProtKB-AC P25728 http://www.uniprot.org/uniprot/P25728 charge swissprot:YGBA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGBA_ECOLI eggNOG ENOG4105VXR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VXR eggNOG ENOG41121K2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41121K2 epestfind swissprot:YGBA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGBA_ECOLI garnier swissprot:YGBA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGBA_ECOLI helixturnhelix swissprot:YGBA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGBA_ECOLI hmoment swissprot:YGBA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGBA_ECOLI iep swissprot:YGBA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGBA_ECOLI inforesidue swissprot:YGBA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGBA_ECOLI octanol swissprot:YGBA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGBA_ECOLI pepcoil swissprot:YGBA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGBA_ECOLI pepdigest swissprot:YGBA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGBA_ECOLI pepinfo swissprot:YGBA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGBA_ECOLI pepnet swissprot:YGBA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGBA_ECOLI pepstats swissprot:YGBA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGBA_ECOLI pepwheel swissprot:YGBA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGBA_ECOLI pepwindow swissprot:YGBA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGBA_ECOLI sigcleave swissprot:YGBA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGBA_ECOLI ## Database ID URL or Descriptions # BioGrid 4263513 126 # EcoGene EG13098 yqeG # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0003333 amino acid transmembrane transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0055085 transmembrane transport # InterPro IPR018227 Tryptophan/tyrosine_permease # Organism YQEG_ECOLI Escherichia coli (strain K12) # PATRIC 32121108 VBIEscCol129921_2943 # PIR F65067 F65067 # Pfam PF03222 Trp_Tyr_perm # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQEG_ECOLI Inner membrane transport protein YqeG # RefSeq NP_417322 NC_000913.3 # RefSeq WP_000065950 NZ_LN832404.1 # SIMILARITY Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION YQEG_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.42.2 the hydroxy/aromatic amino acid permease (haaap) family # eggNOG COG0814 LUCA # eggNOG ENOG4108MHD Bacteria BLAST swissprot:YQEG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQEG_ECOLI BioCyc ECOL316407:JW2813-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2813-MONOMER BioCyc EcoCyc:B2845-MONOMER http://biocyc.org/getid?id=EcoCyc:B2845-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 EchoBASE EB2901 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2901 EcoGene EG13098 http://www.ecogene.org/geneInfo.php?eg_id=EG13098 EnsemblBacteria AAC75884 http://www.ensemblgenomes.org/id/AAC75884 EnsemblBacteria AAC75884 http://www.ensemblgenomes.org/id/AAC75884 EnsemblBacteria BAE76914 http://www.ensemblgenomes.org/id/BAE76914 EnsemblBacteria BAE76914 http://www.ensemblgenomes.org/id/BAE76914 EnsemblBacteria BAE76914 http://www.ensemblgenomes.org/id/BAE76914 EnsemblBacteria b2845 http://www.ensemblgenomes.org/id/b2845 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0003333 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003333 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 945028 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945028 HOGENOM HOG000270787 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000270787&db=HOGENOM6 InterPro IPR018227 http://www.ebi.ac.uk/interpro/entry/IPR018227 KEGG_Gene ecj:JW2813 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2813 KEGG_Gene eco:b2845 http://www.genome.jp/dbget-bin/www_bget?eco:b2845 OMA YWPHRAL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YWPHRAL PSORT swissprot:YQEG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQEG_ECOLI PSORT-B swissprot:YQEG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQEG_ECOLI PSORT2 swissprot:YQEG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQEG_ECOLI Pfam PF03222 http://pfam.xfam.org/family/PF03222 Phobius swissprot:YQEG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQEG_ECOLI PhylomeDB P63340 http://phylomedb.org/?seqid=P63340 ProteinModelPortal P63340 http://www.proteinmodelportal.org/query/uniprot/P63340 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417322 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417322 RefSeq WP_000065950 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000065950 STRING 511145.b2845 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2845&targetmode=cogs TCDB 2.A.42.2 http://www.tcdb.org/search/result.php?tc=2.A.42.2 UniProtKB YQEG_ECOLI http://www.uniprot.org/uniprot/YQEG_ECOLI UniProtKB-AC P63340 http://www.uniprot.org/uniprot/P63340 charge swissprot:YQEG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQEG_ECOLI eggNOG COG0814 http://eggnogapi.embl.de/nog_data/html/tree/COG0814 eggNOG ENOG4108MHD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MHD epestfind swissprot:YQEG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQEG_ECOLI garnier swissprot:YQEG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQEG_ECOLI helixturnhelix swissprot:YQEG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQEG_ECOLI hmoment swissprot:YQEG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQEG_ECOLI iep swissprot:YQEG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQEG_ECOLI inforesidue swissprot:YQEG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQEG_ECOLI octanol swissprot:YQEG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQEG_ECOLI pepcoil swissprot:YQEG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQEG_ECOLI pepdigest swissprot:YQEG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQEG_ECOLI pepinfo swissprot:YQEG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQEG_ECOLI pepnet swissprot:YQEG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQEG_ECOLI pepstats swissprot:YQEG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQEG_ECOLI pepwheel swissprot:YQEG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQEG_ECOLI pepwindow swissprot:YQEG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQEG_ECOLI sigcleave swissprot:YQEG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQEG_ECOLI ## Database ID URL or Descriptions # BioGrid 4261571 9 # COFACTOR YNFE_ECOLI Name=Mo-bis(molybdopterin guanine dinucleotide); Xref=ChEBI CHEBI 60539; Evidence={ECO 0000250}; Note=Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit. {ECO 0000250}; # COFACTOR YNFE_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000305}; Note=Binds 1 [4Fe-4S] cluster. {ECO 0000305}; # EcoGene EG13843 ynfE # FUNCTION YNFE_ECOLI Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. {ECO 0000250}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_function GO:0009055 electron carrier activity; IEA:InterPro. # GO_function GO:0009389 dimethyl sulfoxide reductase activity; IEA:InterPro. # GO_function GO:0030151 molybdenum ion binding; IEA:InterPro. # GO_function GO:0033797 selenate reductase activity; IMP:EcoCyc. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # INTERACTION YNFE_ECOLI P69853 dmsD; NbExp=3; IntAct=EBI-556186, EBI-4406374; # IntAct P77374 5 # InterPro IPR006311 TAT_signal # InterPro IPR006655 Mopterin_OxRdtase_prok_CS # InterPro IPR006656 Mopterin_OxRdtase # InterPro IPR006657 MoPterin_dinucl-bd_dom # InterPro IPR006963 Mopterin_OxRdtase_4Fe-4S_dom # InterPro IPR009010 Asp_de-COase-like_dom # InterPro IPR011888 Anaer_DMSO_reductase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko00450 Selenocompound metabolism # Organism YNFE_ECOLI Escherichia coli (strain K12) # PATRIC 32118476 VBIEscCol129921_1658 # PIR E64914 E64914 # PROSITE PS00932 MOLYBDOPTERIN_PROK_3 # PROSITE PS51318 TAT # PROSITE PS51669 4FE4S_MOW_BIS_MGD # PTM YNFE_ECOLI Exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven. # Pfam PF00384 Molybdopterin # Pfam PF01568 Molydop_binding # Pfam PF04879 Molybdop_Fe4S4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNFE_ECOLI Putative dimethyl sulfoxide reductase chain YnfE # RefSeq NP_416104 NC_000913.3 # RefSeq WP_000041675 NZ_LN832404.1 # SIMILARITY Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. {ECO 0000305}. # SIMILARITY Contains 1 4Fe-4S Mo/W bis-MGD-type domain. {ECO:0000255|PROSITE-ProRule PRU01004}. # SMART SM00926 Molybdop_Fe4S4 # SUBCELLULAR LOCATION YNFE_ECOLI Cell membrane {ECO 0000250}; Peripheral membrane protein {ECO 0000250}; Cytoplasmic side {ECO 0000250}. # SUPFAM SSF50692 SSF50692 # TCDB 5.A.3.3 the prokaryotic molybdopterin-containing oxidoreductase (pmo) family # TIGRFAMs TIGR02166 dmsA_ynfE # eggNOG COG0243 LUCA # eggNOG ENOG4107QY8 Bacteria BLAST swissprot:YNFE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNFE_ECOLI BioCyc ECOL316407:JW1579-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1579-MONOMER BioCyc EcoCyc:G6845-MONOMER http://biocyc.org/getid?id=EcoCyc:G6845-MONOMER BioCyc MetaCyc:G6845-MONOMER http://biocyc.org/getid?id=MetaCyc:G6845-MONOMER COG COG0243 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0243 DIP DIP-12765N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12765N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M610507200 http://dx.doi.org/10.1074/jbc.M610507200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.8.99.- http://www.genome.jp/dbget-bin/www_bget?EC:1.8.99.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.8.99.- http://enzyme.expasy.org/EC/1.8.99.- EchoBASE EB3604 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3604 EcoGene EG13843 http://www.ecogene.org/geneInfo.php?eg_id=EG13843 EnsemblBacteria AAC74659 http://www.ensemblgenomes.org/id/AAC74659 EnsemblBacteria AAC74659 http://www.ensemblgenomes.org/id/AAC74659 EnsemblBacteria BAA15311 http://www.ensemblgenomes.org/id/BAA15311 EnsemblBacteria BAA15311 http://www.ensemblgenomes.org/id/BAA15311 EnsemblBacteria BAA15311 http://www.ensemblgenomes.org/id/BAA15311 EnsemblBacteria b1587 http://www.ensemblgenomes.org/id/b1587 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0009389 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009389 GO_function GO:0030151 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030151 GO_function GO:0033797 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033797 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GeneID 946135 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946135 HOGENOM HOG000284390 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000284390&db=HOGENOM6 InParanoid P77374 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77374 IntAct P77374 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77374* IntEnz 1.8.99 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.8.99 InterPro IPR006311 http://www.ebi.ac.uk/interpro/entry/IPR006311 InterPro IPR006655 http://www.ebi.ac.uk/interpro/entry/IPR006655 InterPro IPR006656 http://www.ebi.ac.uk/interpro/entry/IPR006656 InterPro IPR006657 http://www.ebi.ac.uk/interpro/entry/IPR006657 InterPro IPR006963 http://www.ebi.ac.uk/interpro/entry/IPR006963 InterPro IPR009010 http://www.ebi.ac.uk/interpro/entry/IPR009010 InterPro IPR011888 http://www.ebi.ac.uk/interpro/entry/IPR011888 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1579 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1579 KEGG_Gene eco:b1587 http://www.genome.jp/dbget-bin/www_bget?eco:b1587 KEGG_Orthology KO:K07309 http://www.genome.jp/dbget-bin/www_bget?KO:K07309 KEGG_Pathway ko00450 http://www.genome.jp/kegg-bin/show_pathway?ko00450 OMA ITIERMP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ITIERMP PROSITE PS00932 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00932 PROSITE PS51318 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51318 PROSITE PS51669 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51669 PSORT swissprot:YNFE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNFE_ECOLI PSORT-B swissprot:YNFE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNFE_ECOLI PSORT2 swissprot:YNFE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNFE_ECOLI Pfam PF00384 http://pfam.xfam.org/family/PF00384 Pfam PF01568 http://pfam.xfam.org/family/PF01568 Pfam PF04879 http://pfam.xfam.org/family/PF04879 Phobius swissprot:YNFE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNFE_ECOLI PhylomeDB P77374 http://phylomedb.org/?seqid=P77374 ProteinModelPortal P77374 http://www.proteinmodelportal.org/query/uniprot/P77374 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17218314 http://www.ncbi.nlm.nih.gov/pubmed/17218314 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416104 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416104 RefSeq WP_000041675 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000041675 SMART SM00926 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00926 SMR P77374 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77374 STRING 511145.b1587 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1587&targetmode=cogs STRING COG0243 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0243&targetmode=cogs SUPFAM SSF50692 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50692 TCDB 5.A.3.3 http://www.tcdb.org/search/result.php?tc=5.A.3.3 TIGRFAMs TIGR02166 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02166 UniProtKB YNFE_ECOLI http://www.uniprot.org/uniprot/YNFE_ECOLI UniProtKB-AC P77374 http://www.uniprot.org/uniprot/P77374 charge swissprot:YNFE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNFE_ECOLI eggNOG COG0243 http://eggnogapi.embl.de/nog_data/html/tree/COG0243 eggNOG ENOG4107QY8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QY8 epestfind swissprot:YNFE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNFE_ECOLI garnier swissprot:YNFE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNFE_ECOLI helixturnhelix swissprot:YNFE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNFE_ECOLI hmoment swissprot:YNFE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNFE_ECOLI iep swissprot:YNFE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNFE_ECOLI inforesidue swissprot:YNFE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNFE_ECOLI octanol swissprot:YNFE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNFE_ECOLI pepcoil swissprot:YNFE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNFE_ECOLI pepdigest swissprot:YNFE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNFE_ECOLI pepinfo swissprot:YNFE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNFE_ECOLI pepnet swissprot:YNFE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNFE_ECOLI pepstats swissprot:YNFE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNFE_ECOLI pepwheel swissprot:YNFE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNFE_ECOLI pepwindow swissprot:YNFE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNFE_ECOLI sigcleave swissprot:YNFE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNFE_ECOLI ## Database ID URL or Descriptions # AltName PHOH_ECOLI Phosphate starvation-inducible protein PsiH # BioGrid 4260054 9 # EcoGene EG11734 phoH # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0005524 ATP binding; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.300 -; 1. # INDUCTION PHOH_ECOLI By phosphate starvation. # InterPro IPR003714 PhoH # InterPro IPR027417 P-loop_NTPase # Organism PHOH_ECOLI Escherichia coli (strain K12) # PATRIC 32117273 VBIEscCol129921_1060 # PIR B47065 B47065 # Pfam PF02562 PhoH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PHOH_ECOLI Protein PhoH # RefSeq NP_415539 NC_000913.3 # SIMILARITY Belongs to the PhoH family. {ECO 0000305}. # SUBCELLULAR LOCATION PHOH_ECOLI Cytoplasm. # SUPFAM SSF52540 SSF52540 # eggNOG COG1702 LUCA # eggNOG ENOG4105D5M Bacteria BLAST swissprot:PHOH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PHOH_ECOLI BioCyc ECOL316407:JW1005-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1005-MONOMER BioCyc EcoCyc:EG11734-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11734-MONOMER COG COG1702 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1702 DIP DIP-10499N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10499N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D10391 http://www.ebi.ac.uk/ena/data/view/D10391 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1685 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1685 EcoGene EG11734 http://www.ecogene.org/geneInfo.php?eg_id=EG11734 EnsemblBacteria AAC74105 http://www.ensemblgenomes.org/id/AAC74105 EnsemblBacteria AAC74105 http://www.ensemblgenomes.org/id/AAC74105 EnsemblBacteria BAA35801 http://www.ensemblgenomes.org/id/BAA35801 EnsemblBacteria BAA35801 http://www.ensemblgenomes.org/id/BAA35801 EnsemblBacteria BAA35801 http://www.ensemblgenomes.org/id/BAA35801 EnsemblBacteria b1020 http://www.ensemblgenomes.org/id/b1020 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948010 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948010 HOGENOM HOG000015043 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000015043&db=HOGENOM6 InParanoid P0A9K1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9K1 InterPro IPR003714 http://www.ebi.ac.uk/interpro/entry/IPR003714 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Gene ecj:JW1005 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1005 KEGG_Gene eco:b1020 http://www.genome.jp/dbget-bin/www_bget?eco:b1020 KEGG_Orthology KO:K06217 http://www.genome.jp/dbget-bin/www_bget?KO:K06217 OMA FLQYCLR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FLQYCLR PSORT swissprot:PHOH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PHOH_ECOLI PSORT-B swissprot:PHOH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PHOH_ECOLI PSORT2 swissprot:PHOH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PHOH_ECOLI Pfam PF02562 http://pfam.xfam.org/family/PF02562 Phobius swissprot:PHOH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PHOH_ECOLI PhylomeDB P0A9K1 http://phylomedb.org/?seqid=P0A9K1 ProteinModelPortal P0A9K1 http://www.proteinmodelportal.org/query/uniprot/P0A9K1 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2160940 http://www.ncbi.nlm.nih.gov/pubmed/2160940 PubMed 8444794 http://www.ncbi.nlm.nih.gov/pubmed/8444794 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415539 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415539 SMR P0A9K1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9K1 STRING 511145.b1020 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1020&targetmode=cogs STRING COG1702 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1702&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB PHOH_ECOLI http://www.uniprot.org/uniprot/PHOH_ECOLI UniProtKB-AC P0A9K1 http://www.uniprot.org/uniprot/P0A9K1 charge swissprot:PHOH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PHOH_ECOLI eggNOG COG1702 http://eggnogapi.embl.de/nog_data/html/tree/COG1702 eggNOG ENOG4105D5M http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D5M epestfind swissprot:PHOH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PHOH_ECOLI garnier swissprot:PHOH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PHOH_ECOLI helixturnhelix swissprot:PHOH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PHOH_ECOLI hmoment swissprot:PHOH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PHOH_ECOLI iep swissprot:PHOH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PHOH_ECOLI inforesidue swissprot:PHOH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PHOH_ECOLI octanol swissprot:PHOH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PHOH_ECOLI pepcoil swissprot:PHOH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PHOH_ECOLI pepdigest swissprot:PHOH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PHOH_ECOLI pepinfo swissprot:PHOH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PHOH_ECOLI pepnet swissprot:PHOH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PHOH_ECOLI pepstats swissprot:PHOH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PHOH_ECOLI pepwheel swissprot:PHOH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PHOH_ECOLI pepwindow swissprot:PHOH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PHOH_ECOLI sigcleave swissprot:PHOH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PHOH_ECOLI ## Database ID URL or Descriptions # BioGrid 4262681 9 # EcoGene EG12458 alsB # FUNCTION ALSB_ECOLI Part of the binding-protein-dependent transport system AlsBAC for D-allose. {ECO 0000269|PubMed 9401019}. # GO_component GO:0005886 plasma membrane; IBA:GO_Central. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_component GO:0016021 integral component of membrane; IBA:GO_Central. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0015145 monosaccharide transmembrane transporter activity; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # IntAct P39265 6 # InterPro IPR025997 SBP_2_dom # InterPro IPR028082 Peripla_BP_I # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00217 D-Allose transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism ALSB_ECOLI Escherichia coli (strain K12) # PATRIC 32123733 VBIEscCol129921_4215 # PDB 1GUB X-ray; 3.10 A; A=24-311 # PDB 1GUD X-ray; 1.70 A; A/B=24-311 # PDB 1RPJ X-ray; 1.80 A; A=24-311 # PIR S56316 S56316 # Pfam PF13407 Peripla_BP_4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ALSB_ECOLI D-allose-binding periplasmic protein # RefSeq NP_418512 NC_000913.3 # RefSeq WP_001046187 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial solute-binding protein 2 family. {ECO 0000305}. # SUBCELLULAR LOCATION ALSB_ECOLI Periplasm. # SUPFAM SSF53822 SSF53822 # TCDB 3.A.1.2 the atp-binding cassette (abc) superfamily # eggNOG COG1879 LUCA # eggNOG ENOG4105E9V Bacteria BLAST swissprot:ALSB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ALSB_ECOLI BioCyc ECOL316407:JW4049-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4049-MONOMER BioCyc EcoCyc:YJCX-MONOMER http://biocyc.org/getid?id=EcoCyc:YJCX-MONOMER BioCyc MetaCyc:YJCX-MONOMER http://biocyc.org/getid?id=MetaCyc:YJCX-MONOMER COG COG1879 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1879 DOI 10.1006/jmbi.1999.2571 http://dx.doi.org/10.1006/jmbi.1999.2571 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X82203 http://www.ebi.ac.uk/ena/data/view/X82203 EchoBASE EB2352 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2352 EcoGene EG12458 http://www.ecogene.org/geneInfo.php?eg_id=EG12458 EnsemblBacteria AAC77049 http://www.ensemblgenomes.org/id/AAC77049 EnsemblBacteria AAC77049 http://www.ensemblgenomes.org/id/AAC77049 EnsemblBacteria BAE78091 http://www.ensemblgenomes.org/id/BAE78091 EnsemblBacteria BAE78091 http://www.ensemblgenomes.org/id/BAE78091 EnsemblBacteria BAE78091 http://www.ensemblgenomes.org/id/BAE78091 EnsemblBacteria b4088 http://www.ensemblgenomes.org/id/b4088 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0015145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015145 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GeneID 948604 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948604 HOGENOM HOG000212345 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000212345&db=HOGENOM6 InParanoid P39265 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39265 IntAct P39265 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39265* InterPro IPR025997 http://www.ebi.ac.uk/interpro/entry/IPR025997 InterPro IPR028082 http://www.ebi.ac.uk/interpro/entry/IPR028082 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW4049 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4049 KEGG_Gene eco:b4088 http://www.genome.jp/dbget-bin/www_bget?eco:b4088 KEGG_Orthology KO:K10549 http://www.genome.jp/dbget-bin/www_bget?KO:K10549 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA NVEAFIT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NVEAFIT PDB 1GUB http://www.ebi.ac.uk/pdbe-srv/view/entry/1GUB PDB 1GUD http://www.ebi.ac.uk/pdbe-srv/view/entry/1GUD PDB 1RPJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1RPJ PDBsum 1GUB http://www.ebi.ac.uk/pdbsum/1GUB PDBsum 1GUD http://www.ebi.ac.uk/pdbsum/1GUD PDBsum 1RPJ http://www.ebi.ac.uk/pdbsum/1RPJ PSORT swissprot:ALSB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ALSB_ECOLI PSORT-B swissprot:ALSB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ALSB_ECOLI PSORT2 swissprot:ALSB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ALSB_ECOLI Pfam PF13407 http://pfam.xfam.org/family/PF13407 Phobius swissprot:ALSB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ALSB_ECOLI PhylomeDB P39265 http://phylomedb.org/?seqid=P39265 ProteinModelPortal P39265 http://www.proteinmodelportal.org/query/uniprot/P39265 PubMed 10064713 http://www.ncbi.nlm.nih.gov/pubmed/10064713 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8576032 http://www.ncbi.nlm.nih.gov/pubmed/8576032 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9401019 http://www.ncbi.nlm.nih.gov/pubmed/9401019 RefSeq NP_418512 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418512 RefSeq WP_001046187 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001046187 SMR P39265 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39265 STRING 511145.b4088 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4088&targetmode=cogs STRING COG1879 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1879&targetmode=cogs SUPFAM SSF53822 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822 TCDB 3.A.1.2 http://www.tcdb.org/search/result.php?tc=3.A.1.2 UniProtKB ALSB_ECOLI http://www.uniprot.org/uniprot/ALSB_ECOLI UniProtKB-AC P39265 http://www.uniprot.org/uniprot/P39265 charge swissprot:ALSB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ALSB_ECOLI eggNOG COG1879 http://eggnogapi.embl.de/nog_data/html/tree/COG1879 eggNOG ENOG4105E9V http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E9V epestfind swissprot:ALSB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ALSB_ECOLI garnier swissprot:ALSB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ALSB_ECOLI helixturnhelix swissprot:ALSB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ALSB_ECOLI hmoment swissprot:ALSB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ALSB_ECOLI iep swissprot:ALSB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ALSB_ECOLI inforesidue swissprot:ALSB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ALSB_ECOLI octanol swissprot:ALSB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ALSB_ECOLI pepcoil swissprot:ALSB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ALSB_ECOLI pepdigest swissprot:ALSB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ALSB_ECOLI pepinfo swissprot:ALSB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ALSB_ECOLI pepnet swissprot:ALSB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ALSB_ECOLI pepstats swissprot:ALSB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ALSB_ECOLI pepwheel swissprot:ALSB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ALSB_ECOLI pepwindow swissprot:ALSB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ALSB_ECOLI sigcleave swissprot:ALSB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ALSB_ECOLI ## Database ID URL or Descriptions # AltName TAUA_ECOLI Sulfate starvation-induced protein 1 # BioGrid 4261088 12 # CDD cd13560 PBP2_taurine # EcoGene EG13300 tauA # FUNCTION TAUA_ECOLI Part of a binding-protein-dependent transport system for taurine. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_function GO:0005215 transporter activity; IBA:GO_Central. # GO_process GO:0006810 transport; IBA:GO_Central. # GO_process GO:0009970 cellular response to sulfate starvation; IEP:EcoCyc. # GO_process GO:0015734 taurine transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006810 transport # GOslim_process GO:0006950 response to stress # INDUCTION TAUA_ECOLI Repressed by sulfate or cysteine. # InterPro IPR001638 Solute-binding_3/MltF_N # InterPro IPR007210 ABC_Gly_betaine_transp_sub-bd # InterPro IPR010068 Peri-bd_TauA # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00435 Taurine transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism TAUA_ECOLI Escherichia coli (strain K12) # PATRIC 32115869 VBIEscCol129921_0376 # PIR S78604 S78604 # Pfam PF04069 OpuAC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TAUA_ECOLI Taurine-binding periplasmic protein # RefSeq NP_414899 NC_000913.3 # RefSeq WP_001018417 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18088.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the bacterial solute-binding protein SsuA/TauA family. {ECO 0000305}. # SMART SM00062 PBPb # SUBCELLULAR LOCATION TAUA_ECOLI Periplasm {ECO 0000305}. # TCDB 3.A.1.17 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR01729 taurine_ABC_bnd # eggNOG COG4521 LUCA # eggNOG ENOG4106FTQ Bacteria BLAST swissprot:TAUA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TAUA_ECOLI BioCyc ECOL316407:JW0357-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0357-MONOMER BioCyc EcoCyc:TAUA-MONOMER http://biocyc.org/getid?id=EcoCyc:TAUA-MONOMER BioCyc MetaCyc:TAUA-MONOMER http://biocyc.org/getid?id=MetaCyc:TAUA-MONOMER COG COG4521 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4521 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1432-1033.1996.0773u.x http://dx.doi.org/10.1111/j.1432-1033.1996.0773u.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D85613 http://www.ebi.ac.uk/ena/data/view/D85613 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB3085 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3085 EcoGene EG13300 http://www.ecogene.org/geneInfo.php?eg_id=EG13300 EnsemblBacteria AAC73468 http://www.ensemblgenomes.org/id/AAC73468 EnsemblBacteria AAC73468 http://www.ensemblgenomes.org/id/AAC73468 EnsemblBacteria BAE76146 http://www.ensemblgenomes.org/id/BAE76146 EnsemblBacteria BAE76146 http://www.ensemblgenomes.org/id/BAE76146 EnsemblBacteria BAE76146 http://www.ensemblgenomes.org/id/BAE76146 EnsemblBacteria b0365 http://www.ensemblgenomes.org/id/b0365 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GO_process GO:0009970 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009970 GO_process GO:0015734 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015734 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 945030 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945030 HOGENOM HOG000265079 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000265079&db=HOGENOM6 InParanoid Q47537 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q47537 IntAct Q47537 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q47537* InterPro IPR001638 http://www.ebi.ac.uk/interpro/entry/IPR001638 InterPro IPR007210 http://www.ebi.ac.uk/interpro/entry/IPR007210 InterPro IPR010068 http://www.ebi.ac.uk/interpro/entry/IPR010068 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0357 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0357 KEGG_Gene eco:b0365 http://www.genome.jp/dbget-bin/www_bget?eco:b0365 KEGG_Orthology KO:K15551 http://www.genome.jp/dbget-bin/www_bget?KO:K15551 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA GANVDWR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GANVDWR PSORT swissprot:TAUA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TAUA_ECOLI PSORT-B swissprot:TAUA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TAUA_ECOLI PSORT2 swissprot:TAUA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TAUA_ECOLI Pfam PF04069 http://pfam.xfam.org/family/PF04069 Phobius swissprot:TAUA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TAUA_ECOLI PhylomeDB Q47537 http://phylomedb.org/?seqid=Q47537 ProteinModelPortal Q47537 http://www.proteinmodelportal.org/query/uniprot/Q47537 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8774726 http://www.ncbi.nlm.nih.gov/pubmed/8774726 PubMed 8808933 http://www.ncbi.nlm.nih.gov/pubmed/8808933 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414899 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414899 RefSeq WP_001018417 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001018417 SMART SM00062 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00062 SMR Q47537 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q47537 STRING 511145.b0365 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0365&targetmode=cogs STRING COG4521 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4521&targetmode=cogs TCDB 3.A.1.17 http://www.tcdb.org/search/result.php?tc=3.A.1.17 TIGRFAMs TIGR01729 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01729 UniProtKB TAUA_ECOLI http://www.uniprot.org/uniprot/TAUA_ECOLI UniProtKB-AC Q47537 http://www.uniprot.org/uniprot/Q47537 charge swissprot:TAUA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TAUA_ECOLI eggNOG COG4521 http://eggnogapi.embl.de/nog_data/html/tree/COG4521 eggNOG ENOG4106FTQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106FTQ epestfind swissprot:TAUA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TAUA_ECOLI garnier swissprot:TAUA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TAUA_ECOLI helixturnhelix swissprot:TAUA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TAUA_ECOLI hmoment swissprot:TAUA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TAUA_ECOLI iep swissprot:TAUA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TAUA_ECOLI inforesidue swissprot:TAUA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TAUA_ECOLI octanol swissprot:TAUA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TAUA_ECOLI pepcoil swissprot:TAUA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TAUA_ECOLI pepdigest swissprot:TAUA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TAUA_ECOLI pepinfo swissprot:TAUA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TAUA_ECOLI pepnet swissprot:TAUA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TAUA_ECOLI pepstats swissprot:TAUA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TAUA_ECOLI pepwheel swissprot:TAUA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TAUA_ECOLI pepwindow swissprot:TAUA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TAUA_ECOLI sigcleave swissprot:TAUA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TAUA_ECOLI ## Database ID URL or Descriptions # InterPro IPR020517 Uncharacterised_ArtA # Organism ARTA_ECOLI Escherichia coli (strain K12) # PIR C32238 BVECAA # ProDom PD069248 Uncharacterised_ArtA # RecName ARTA_ECOLI Protein ArtA # RefSeq NP_061472 NC_002483.1 # RefSeq WP_000415566 NZ_CP014273.1 # RefSeq YP_008997936 NC_023315.1 # RefSeq YP_009071250 NC_025179.1 BLAST swissprot:ARTA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARTA_ECOLI EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL M20787 http://www.ebi.ac.uk/ena/data/view/M20787 EMBL U01159 http://www.ebi.ac.uk/ena/data/view/U01159 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1263509 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263509 GeneID 18194765 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18194765 GeneID 20493322 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20493322 InterPro IPR020517 http://www.ebi.ac.uk/interpro/entry/IPR020517 OMA IWSSVIN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IWSSVIN PSORT swissprot:ARTA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARTA_ECOLI PSORT-B swissprot:ARTA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARTA_ECOLI PSORT2 swissprot:ARTA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARTA_ECOLI Phobius swissprot:ARTA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARTA_ECOLI ProteinModelPortal P18032 http://www.proteinmodelportal.org/query/uniprot/P18032 PubMed 2536655 http://www.ncbi.nlm.nih.gov/pubmed/2536655 PubMed 7915817 http://www.ncbi.nlm.nih.gov/pubmed/7915817 RefSeq NP_061472 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061472 RefSeq WP_000415566 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000415566 RefSeq YP_008997936 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_008997936 RefSeq YP_009071250 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009071250 UniProtKB ARTA_ECOLI http://www.uniprot.org/uniprot/ARTA_ECOLI UniProtKB-AC P18032 http://www.uniprot.org/uniprot/P18032 charge swissprot:ARTA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARTA_ECOLI epestfind swissprot:ARTA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARTA_ECOLI garnier swissprot:ARTA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARTA_ECOLI helixturnhelix swissprot:ARTA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARTA_ECOLI hmoment swissprot:ARTA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARTA_ECOLI iep swissprot:ARTA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARTA_ECOLI inforesidue swissprot:ARTA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARTA_ECOLI octanol swissprot:ARTA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARTA_ECOLI pepcoil swissprot:ARTA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARTA_ECOLI pepdigest swissprot:ARTA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARTA_ECOLI pepinfo swissprot:ARTA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARTA_ECOLI pepnet swissprot:ARTA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARTA_ECOLI pepstats swissprot:ARTA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARTA_ECOLI pepwheel swissprot:ARTA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARTA_ECOLI pepwindow swissprot:ARTA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARTA_ECOLI sigcleave swissprot:ARTA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARTA_ECOLI ## Database ID URL or Descriptions # AltName EUTB_ECOLI Ethanolamine ammonia-lyase large subunit # BioGrid 4260578 8 # CATALYTIC ACTIVITY EUTB_ECOLI Ethanolamine = acetaldehyde + NH(3). # COFACTOR Name=adenosylcob(III)alamin; Xref=ChEBI:CHEBI 18408; # EcoGene EG50006 eutB # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0009350 ethanolamine ammonia-lyase complex; IDA:EcoCyc. # GO_function GO:0008851 ethanolamine ammonia-lyase activity; IEA:UniProtKB-EC. # GO_process GO:0006520 cellular amino acid metabolic process; IEA:InterPro. # GO_process GO:0046336 ethanolamine catabolic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.70 -; 1. # InterPro IPR010628 EutB # InterPro IPR013785 Aldolase_TIM # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00564 Glycerophospholipid metabolism # Organism EUTB_ECOLI Escherichia coli (strain K12) # PATHWAY EUTB_ECOLI Amine and polyamine degradation; ethanolamine degradation. # PATRIC 32120267 VBIEscCol129921_2536 # PDB 3ABO X-ray; 2.10 A; A/C=1-453 # PDB 3ABQ X-ray; 2.05 A; A/C=1-453 # PDB 3ABR X-ray; 2.10 A; A/C=1-453 # PDB 3ABS X-ray; 2.25 A; A/C=1-453 # PDB 3ANY X-ray; 2.10 A; A/C=1-453 # PDB 3AO0 X-ray; 2.25 A; A/C=1-453 # PIR H65018 H65018 # PIRSF PIRSF018788 EutB # Pfam PF06751 EutB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EUTB_ECOLI Ethanolamine ammonia-lyase heavy chain # RefSeq NP_416936 NC_000913.3 # RefSeq WP_000769961 NZ_LN832404.1 # SUBUNIT EUTB_ECOLI Heterodimer of two non-identical chains. # eggNOG COG4303 LUCA # eggNOG ENOG4105CPD Bacteria BLAST swissprot:EUTB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EUTB_ECOLI BioCyc ECOL316407:JW2434-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2434-MONOMER BioCyc EcoCyc:EUTB-MONOMER http://biocyc.org/getid?id=EcoCyc:EUTB-MONOMER BioCyc MetaCyc:EUTB-MONOMER http://biocyc.org/getid?id=MetaCyc:EUTB-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.3.1.7 http://www.genome.jp/dbget-bin/www_bget?EC:4.3.1.7 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 4.3.1.7 http://enzyme.expasy.org/EC/4.3.1.7 EchoBASE EB4299 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4299 EcoGene EG50006 http://www.ecogene.org/geneInfo.php?eg_id=EG50006 EnsemblBacteria AAC75494 http://www.ensemblgenomes.org/id/AAC75494 EnsemblBacteria AAC75494 http://www.ensemblgenomes.org/id/AAC75494 EnsemblBacteria BAA16323 http://www.ensemblgenomes.org/id/BAA16323 EnsemblBacteria BAA16323 http://www.ensemblgenomes.org/id/BAA16323 EnsemblBacteria BAA16323 http://www.ensemblgenomes.org/id/BAA16323 EnsemblBacteria b2441 http://www.ensemblgenomes.org/id/b2441 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0009350 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009350 GO_function GO:0008851 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008851 GO_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GO_process GO:0046336 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046336 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 946924 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946924 HOGENOM HOG000288958 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000288958&db=HOGENOM6 InParanoid P0AEJ6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEJ6 IntAct P0AEJ6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEJ6* IntEnz 4.3.1.7 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.3.1.7 InterPro IPR010628 http://www.ebi.ac.uk/interpro/entry/IPR010628 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2434 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2434 KEGG_Gene eco:b2441 http://www.genome.jp/dbget-bin/www_bget?eco:b2441 KEGG_Orthology KO:K03735 http://www.genome.jp/dbget-bin/www_bget?KO:K03735 KEGG_Pathway ko00564 http://www.genome.jp/kegg-bin/show_pathway?ko00564 KEGG_Reaction rn:R00749 http://www.genome.jp/dbget-bin/www_bget?rn:R00749 OMA SIPTQGC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SIPTQGC PDB 3ABO http://www.ebi.ac.uk/pdbe-srv/view/entry/3ABO PDB 3ABQ http://www.ebi.ac.uk/pdbe-srv/view/entry/3ABQ PDB 3ABR http://www.ebi.ac.uk/pdbe-srv/view/entry/3ABR PDB 3ABS http://www.ebi.ac.uk/pdbe-srv/view/entry/3ABS PDB 3ANY http://www.ebi.ac.uk/pdbe-srv/view/entry/3ANY PDB 3AO0 http://www.ebi.ac.uk/pdbe-srv/view/entry/3AO0 PDBsum 3ABO http://www.ebi.ac.uk/pdbsum/3ABO PDBsum 3ABQ http://www.ebi.ac.uk/pdbsum/3ABQ PDBsum 3ABR http://www.ebi.ac.uk/pdbsum/3ABR PDBsum 3ABS http://www.ebi.ac.uk/pdbsum/3ABS PDBsum 3ANY http://www.ebi.ac.uk/pdbsum/3ANY PDBsum 3AO0 http://www.ebi.ac.uk/pdbsum/3AO0 PSORT swissprot:EUTB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EUTB_ECOLI PSORT-B swissprot:EUTB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EUTB_ECOLI PSORT2 swissprot:EUTB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EUTB_ECOLI Pfam PF06751 http://pfam.xfam.org/family/PF06751 Phobius swissprot:EUTB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EUTB_ECOLI PhylomeDB P0AEJ6 http://phylomedb.org/?seqid=P0AEJ6 ProteinModelPortal P0AEJ6 http://www.proteinmodelportal.org/query/uniprot/P0AEJ6 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2197274 http://www.ncbi.nlm.nih.gov/pubmed/2197274 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416936 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416936 RefSeq WP_000769961 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000769961 SMR P0AEJ6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEJ6 STRING 511145.b2441 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2441&targetmode=cogs UniProtKB EUTB_ECOLI http://www.uniprot.org/uniprot/EUTB_ECOLI UniProtKB-AC P0AEJ6 http://www.uniprot.org/uniprot/P0AEJ6 charge swissprot:EUTB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EUTB_ECOLI eggNOG COG4303 http://eggnogapi.embl.de/nog_data/html/tree/COG4303 eggNOG ENOG4105CPD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CPD epestfind swissprot:EUTB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EUTB_ECOLI garnier swissprot:EUTB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EUTB_ECOLI helixturnhelix swissprot:EUTB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EUTB_ECOLI hmoment swissprot:EUTB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EUTB_ECOLI iep swissprot:EUTB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EUTB_ECOLI inforesidue swissprot:EUTB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EUTB_ECOLI octanol swissprot:EUTB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EUTB_ECOLI pepcoil swissprot:EUTB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EUTB_ECOLI pepdigest swissprot:EUTB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EUTB_ECOLI pepinfo swissprot:EUTB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EUTB_ECOLI pepnet swissprot:EUTB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EUTB_ECOLI pepstats swissprot:EUTB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EUTB_ECOLI pepwheel swissprot:EUTB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EUTB_ECOLI pepwindow swissprot:EUTB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EUTB_ECOLI sigcleave swissprot:EUTB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EUTB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260392 7 # EcoGene EG11659 yedD # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GOslim_component GO:0005886 plasma membrane # IntAct P31063 12 # InterPro IPR025596 YedD # Organism YEDD_ECOLI Escherichia coli (strain K12) # PATRIC 32119191 VBIEscCol129921_2010 # PIR E64956 E64956 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF13987 YedD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEDD_ECOLI Uncharacterized lipoprotein YedD # RefSeq NP_416438 NC_000913.3 # RefSeq WP_001350519 NZ_LN832404.1 # SUBCELLULAR LOCATION YEDD_ECOLI Cell membrane {ECO 0000255|PROSITE- ProRule PRU00303}; Lipid-anchor {ECO 0000255|PROSITE- ProRule PRU00303}. # eggNOG ENOG4108W9D Bacteria # eggNOG ENOG4111MXI LUCA BLAST swissprot:YEDD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEDD_ECOLI BioCyc ECOL316407:JW1913-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1913-MONOMER BioCyc EcoCyc:EG11659-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11659-MONOMER DIP DIP-11838N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11838N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1099/00221287-139-7-1401 http://dx.doi.org/10.1099/00221287-139-7-1401 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L13279 http://www.ebi.ac.uk/ena/data/view/L13279 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1611 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1611 EcoGene EG11659 http://www.ecogene.org/geneInfo.php?eg_id=EG11659 EnsemblBacteria AAC74995 http://www.ensemblgenomes.org/id/AAC74995 EnsemblBacteria AAC74995 http://www.ensemblgenomes.org/id/AAC74995 EnsemblBacteria BAA15756 http://www.ensemblgenomes.org/id/BAA15756 EnsemblBacteria BAA15756 http://www.ensemblgenomes.org/id/BAA15756 EnsemblBacteria BAA15756 http://www.ensemblgenomes.org/id/BAA15756 EnsemblBacteria b1928 http://www.ensemblgenomes.org/id/b1928 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 949082 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949082 HOGENOM HOG000121299 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000121299&db=HOGENOM6 IntAct P31063 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31063* InterPro IPR025596 http://www.ebi.ac.uk/interpro/entry/IPR025596 KEGG_Gene ecj:JW1913 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1913 KEGG_Gene eco:b1928 http://www.genome.jp/dbget-bin/www_bget?eco:b1928 MINT MINT-1248078 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1248078 OMA QRVDRPT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QRVDRPT PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YEDD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEDD_ECOLI PSORT-B swissprot:YEDD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEDD_ECOLI PSORT2 swissprot:YEDD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEDD_ECOLI Pfam PF13987 http://pfam.xfam.org/family/PF13987 Phobius swissprot:YEDD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEDD_ECOLI ProteinModelPortal P31063 http://www.proteinmodelportal.org/query/uniprot/P31063 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8371104 http://www.ncbi.nlm.nih.gov/pubmed/8371104 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416438 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416438 RefSeq WP_001350519 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001350519 SMR P31063 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31063 STRING 511145.b1928 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1928&targetmode=cogs UniProtKB YEDD_ECOLI http://www.uniprot.org/uniprot/YEDD_ECOLI UniProtKB-AC P31063 http://www.uniprot.org/uniprot/P31063 charge swissprot:YEDD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEDD_ECOLI eggNOG ENOG4108W9D http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108W9D eggNOG ENOG4111MXI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111MXI epestfind swissprot:YEDD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEDD_ECOLI garnier swissprot:YEDD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEDD_ECOLI helixturnhelix swissprot:YEDD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEDD_ECOLI hmoment swissprot:YEDD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEDD_ECOLI iep swissprot:YEDD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEDD_ECOLI inforesidue swissprot:YEDD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEDD_ECOLI octanol swissprot:YEDD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEDD_ECOLI pepcoil swissprot:YEDD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEDD_ECOLI pepdigest swissprot:YEDD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEDD_ECOLI pepinfo swissprot:YEDD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEDD_ECOLI pepnet swissprot:YEDD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEDD_ECOLI pepstats swissprot:YEDD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEDD_ECOLI pepwheel swissprot:YEDD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEDD_ECOLI pepwindow swissprot:YEDD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEDD_ECOLI sigcleave swissprot:YEDD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEDD_ECOLI ## Database ID URL or Descriptions # BioGrid 4261109 689 # DISRUPTION PHENOTYPE CAS5_ECOLI Loss of resistance to bacteriophage lambda infection, loss of plasmid silencing. Decreased levels of crRNA. {ECO 0000269|PubMed 18703739, ECO 0000269|PubMed 21255106, ECO 0000269|PubMed 21460843}. # EcoGene EG13116 casD # FUNCTION CAS5_ECOLI A component of Cascade, which participates in CRISPR interference, the third stage of CRISPR immunity. Cascade binds both crRNA and in a sequence-specific manner negatively supercoiled dsDNA target. This leads to the formation of an R-loop in which the crRNA binds the target DNA, displacing the noncomplementary strand. Cas3 is recruited to Cascade, nicks target DNA and then unwinds and cleaves the target, leading to DNA degradation and invader neutralization. CasCDE alone is also able to form R-loops. # FUNCTION CAS5_ECOLI CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). # GO_component GO:0043234 protein complex; IDA:EcoCyc. # GO_function GO:0003723 RNA binding; IDA:EcoCyc. # GO_function GO:0071667 DNA/RNA hybrid binding; IDA:EcoCyc. # GO_process GO:0043571 maintenance of CRISPR repeat elements; IEA:InterPro. # GO_process GO:0051607 defense response to virus; IDA:EcoCyc. # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003723 RNA binding # GOslim_process GO:0002376 immune system process # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0044403 symbiosis, encompassing mutualism through parasitism # GOslim_process GO:0051276 chromosome organization # INDUCTION CAS5_ECOLI Repressed by H-NS, activated by LeuO. Activated by the BaeSR two-component regulatory system, possibly due to envelope stress. Part of the casABCDE-ygbT-ygbF operon. {ECO 0000269|PubMed 19429622, ECO 0000269|PubMed 20132443, ECO 0000269|PubMed 21255106}. # InterPro IPR010147 CRISPR-assoc_prot_CasD # InterPro IPR013422 CRISPR-assoc_prot_Cas5_N # InterPro IPR021124 CRISPR-assoc_prot_Cas5 # MASS SPECTROMETRY Mass=25210.4; Mass_error=3.8; Method=Unknown; Range=1-224; Evidence={ECO:0000269|PubMed 21460843}; # Organism CAS5_ECOLI Escherichia coli (strain K12) # PATRIC 32120924 VBIEscCol129921_2854 # PDB 4QYZ X-ray; 3.03 A; J=1-224 # PDB 4TVX X-ray; 3.24 A; H/T=1-224 # PDB 4U7U X-ray; 3.00 A; K/W=1-224 # PDB 5CD4 X-ray; 3.20 A; H/T=1-224 # PDB 5H9E X-ray; 3.21 A; J=1-224 # PDB 5H9F X-ray; 2.45 A; J=1-224 # PIR A65057 A65057 # Pfam PF09704 Cas_Cas5d # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CAS5_ECOLI CRISPR system Cascade subunit CasD # RefSeq NP_417237 NC_000913.3 # RefSeq WP_001334996 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA69267.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the CRISPR-associated protein Cas5 family. Subtype I-E/Ecoli subfamily. {ECO 0000305}. # SUBUNIT CAS5_ECOLI Part of the Cascade ribonucleoprotein complex, with stoichiometry CasA(1),CasB(2),CasC(6),CasD(1),CasE(1)-crRNA(1). Interacts directly with CasA and CasC. Stable subcomplexes of CasBCDE-crRNA and CasCDE-crRNA also form, both of which are able to bind target dsDNA, and at least CasCDE is able to form R-loops. CasCDE and CasCE complexes have endonuclease activity. Binding of target ssRNA or dsDNA causes a conformational change in the Cascade complex. {ECO 0000269|PubMed 18703739, ECO 0000269|PubMed 21255106, ECO 0000269|PubMed 21460843, ECO 0000269|PubMed 21699496, ECO 0000269|PubMed 21938068, ECO 0000269|PubMed 22521689}. # TIGRFAMs TIGR01868 casD_Cas5e # TIGRFAMs TIGR02593 CRISPR_cas5 # eggNOG ENOG4108VWQ Bacteria # eggNOG ENOG4111JEJ LUCA BLAST swissprot:CAS5_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CAS5_ECOLI BioCyc ECOL316407:JW5844-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5844-MONOMER BioCyc EcoCyc:G7427-MONOMER http://biocyc.org/getid?id=EcoCyc:G7427-MONOMER BioCyc MetaCyc:G7427-MONOMER http://biocyc.org/getid?id=MetaCyc:G7427-MONOMER DIP DIP-12125N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12125N DOI 10.1016/j.molcel.2012.03.018 http://dx.doi.org/10.1016/j.molcel.2012.03.018 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature10402 http://dx.doi.org/10.1038/nature10402 DOI 10.1038/nsmb.2019 http://dx.doi.org/10.1038/nsmb.2019 DOI 10.1042/BJ20110901 http://dx.doi.org/10.1042/BJ20110901 DOI 10.1111/j.1365-2958.2010.07073.x http://dx.doi.org/10.1111/j.1365-2958.2010.07073.x DOI 10.1111/j.1365-2958.2010.07482.x http://dx.doi.org/10.1111/j.1365-2958.2010.07482.x DOI 10.1126/science.1159689 http://dx.doi.org/10.1126/science.1159689 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00108-09 http://dx.doi.org/10.1128/JB.00108-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EchoBASE EB2917 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2917 EcoGene EG13116 http://www.ecogene.org/geneInfo.php?eg_id=EG13116 EnsemblBacteria AAC75799 http://www.ensemblgenomes.org/id/AAC75799 EnsemblBacteria AAC75799 http://www.ensemblgenomes.org/id/AAC75799 EnsemblBacteria BAE76834 http://www.ensemblgenomes.org/id/BAE76834 EnsemblBacteria BAE76834 http://www.ensemblgenomes.org/id/BAE76834 EnsemblBacteria BAE76834 http://www.ensemblgenomes.org/id/BAE76834 EnsemblBacteria b2757 http://www.ensemblgenomes.org/id/b2757 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0071667 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071667 GO_process GO:0043571 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043571 GO_process GO:0051607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051607 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_process GO:0002376 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0044403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403 GOslim_process GO:0051276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051276 GeneID 947225 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947225 HOGENOM HOG000015840 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000015840&db=HOGENOM6 InParanoid Q46898 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46898 InterPro IPR010147 http://www.ebi.ac.uk/interpro/entry/IPR010147 InterPro IPR013422 http://www.ebi.ac.uk/interpro/entry/IPR013422 InterPro IPR021124 http://www.ebi.ac.uk/interpro/entry/IPR021124 KEGG_Gene ecj:JW5844 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5844 KEGG_Gene eco:b2757 http://www.genome.jp/dbget-bin/www_bget?eco:b2757 OMA EGICYWD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EGICYWD PDB 4QYZ http://www.ebi.ac.uk/pdbe-srv/view/entry/4QYZ PDB 4TVX http://www.ebi.ac.uk/pdbe-srv/view/entry/4TVX PDB 4U7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U7U PDB 5CD4 http://www.ebi.ac.uk/pdbe-srv/view/entry/5CD4 PDB 5H9E http://www.ebi.ac.uk/pdbe-srv/view/entry/5H9E PDB 5H9F http://www.ebi.ac.uk/pdbe-srv/view/entry/5H9F PDBsum 4QYZ http://www.ebi.ac.uk/pdbsum/4QYZ PDBsum 4TVX http://www.ebi.ac.uk/pdbsum/4TVX PDBsum 4U7U http://www.ebi.ac.uk/pdbsum/4U7U PDBsum 5CD4 http://www.ebi.ac.uk/pdbsum/5CD4 PDBsum 5H9E http://www.ebi.ac.uk/pdbsum/5H9E PDBsum 5H9F http://www.ebi.ac.uk/pdbsum/5H9F PSORT swissprot:CAS5_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CAS5_ECOLI PSORT-B swissprot:CAS5_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CAS5_ECOLI PSORT2 swissprot:CAS5_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CAS5_ECOLI Pfam PF09704 http://pfam.xfam.org/family/PF09704 Phobius swissprot:CAS5_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CAS5_ECOLI ProteinModelPortal Q46898 http://www.proteinmodelportal.org/query/uniprot/Q46898 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18703739 http://www.ncbi.nlm.nih.gov/pubmed/18703739 PubMed 19429622 http://www.ncbi.nlm.nih.gov/pubmed/19429622 PubMed 20132443 http://www.ncbi.nlm.nih.gov/pubmed/20132443 PubMed 21255106 http://www.ncbi.nlm.nih.gov/pubmed/21255106 PubMed 21460843 http://www.ncbi.nlm.nih.gov/pubmed/21460843 PubMed 21699496 http://www.ncbi.nlm.nih.gov/pubmed/21699496 PubMed 21938068 http://www.ncbi.nlm.nih.gov/pubmed/21938068 PubMed 22521689 http://www.ncbi.nlm.nih.gov/pubmed/22521689 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417237 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417237 RefSeq WP_001334996 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001334996 SMR Q46898 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46898 STRING 511145.b2757 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2757&targetmode=cogs TIGRFAMs TIGR01868 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01868 TIGRFAMs TIGR02593 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02593 UniProtKB CAS5_ECOLI http://www.uniprot.org/uniprot/CAS5_ECOLI UniProtKB-AC Q46898 http://www.uniprot.org/uniprot/Q46898 charge swissprot:CAS5_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CAS5_ECOLI eggNOG ENOG4108VWQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108VWQ eggNOG ENOG4111JEJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111JEJ epestfind swissprot:CAS5_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CAS5_ECOLI garnier swissprot:CAS5_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CAS5_ECOLI helixturnhelix swissprot:CAS5_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CAS5_ECOLI hmoment swissprot:CAS5_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CAS5_ECOLI iep swissprot:CAS5_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CAS5_ECOLI inforesidue swissprot:CAS5_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CAS5_ECOLI octanol swissprot:CAS5_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CAS5_ECOLI pepcoil swissprot:CAS5_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CAS5_ECOLI pepdigest swissprot:CAS5_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CAS5_ECOLI pepinfo swissprot:CAS5_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CAS5_ECOLI pepnet swissprot:CAS5_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CAS5_ECOLI pepstats swissprot:CAS5_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CAS5_ECOLI pepwheel swissprot:CAS5_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CAS5_ECOLI pepwindow swissprot:CAS5_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CAS5_ECOLI sigcleave swissprot:CAS5_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CAS5_ECOLI ## Database ID URL or Descriptions # AltName ARNE_ECOLI Undecaprenyl phosphate-aminoarabinose flippase subunit ArnE # BioGrid 4260500 209 # DISRUPTION PHENOTYPE Cells lacking this gene lack L-Ara4N- modified lipid A and are sensitive to polymyxin. {ECO:0000269|PubMed 17928292}. # EcoGene EG14344 arnE # FUNCTION ARNE_ECOLI Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane. {ECO 0000269|PubMed 17928292}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0022891 substrate-specific transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0006810 transport; IMP:EcoCyc. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0009245 lipid A biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0010041 response to iron(III) ion; IGI:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # HAMAP MF_01869 Flippase_ArnE # InterPro IPR000620 EamA_dom # InterPro IPR022883 Flippase_ArnE # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # KEGG_Brite ko02000 Transporters # Organism ARNE_ECOLI Escherichia coli (strain K12) # PATHWAY ARNE_ECOLI Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. # PATRIC 32119881 VBIEscCol129921_2350 # Pfam PF00892 EamA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ARNE_ECOLI Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE # RefSeq WP_000638031 NZ_LN832404.1 # RefSeq YP_588462 NC_000913.3 # SIMILARITY Belongs to the ArnE family. {ECO 0000305}. # SIMILARITY Contains 1 EamA domain. {ECO 0000305}. # SUBCELLULAR LOCATION ARNE_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT Heterodimer of ArnE and ArnF. {ECO:0000305|PubMed 17928292}. # TCDB 2.A.7.22 the drug/metabolite transporter (dmt) superfamily # eggNOG COG0697 LUCA # eggNOG ENOG41060GT Bacteria BLAST swissprot:ARNE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARNE_ECOLI BioCyc ECOL316407:JW2252-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2252-MONOMER BioCyc EcoCyc:MONOMER0-2682 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2682 BioCyc MetaCyc:MONOMER0-2682 http://biocyc.org/getid?id=MetaCyc:MONOMER0-2682 COG COG0697 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0697 DOI 10.1016/0378-1119(95)00721-0 http://dx.doi.org/10.1016/0378-1119(95)00721-0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M706172200 http://dx.doi.org/10.1074/jbc.M706172200 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L35031 http://www.ebi.ac.uk/ena/data/view/L35031 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4090 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4090 EcoGene EG14344 http://www.ecogene.org/geneInfo.php?eg_id=EG14344 EnsemblBacteria ABD18693 http://www.ensemblgenomes.org/id/ABD18693 EnsemblBacteria ABD18693 http://www.ensemblgenomes.org/id/ABD18693 EnsemblBacteria BAE76675 http://www.ensemblgenomes.org/id/BAE76675 EnsemblBacteria BAE76675 http://www.ensemblgenomes.org/id/BAE76675 EnsemblBacteria BAE76675 http://www.ensemblgenomes.org/id/BAE76675 EnsemblBacteria b4544 http://www.ensemblgenomes.org/id/b4544 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0022891 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022891 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GO_process GO:0009245 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009245 GO_process GO:0010041 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010041 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 1450282 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1450282 HAMAP MF_01869 http://hamap.expasy.org/unirule/MF_01869 HOGENOM HOG000261165 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261165&db=HOGENOM6 InParanoid Q47377 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q47377 InterPro IPR000620 http://www.ebi.ac.uk/interpro/entry/IPR000620 InterPro IPR022883 http://www.ebi.ac.uk/interpro/entry/IPR022883 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2252 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2252 KEGG_Gene eco:b4544 http://www.genome.jp/dbget-bin/www_bget?eco:b4544 KEGG_Orthology KO:K12962 http://www.genome.jp/dbget-bin/www_bget?KO:K12962 OMA TCAGQLC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TCAGQLC PSORT swissprot:ARNE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARNE_ECOLI PSORT-B swissprot:ARNE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARNE_ECOLI PSORT2 swissprot:ARNE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARNE_ECOLI Pfam PF00892 http://pfam.xfam.org/family/PF00892 Phobius swissprot:ARNE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARNE_ECOLI ProteinModelPortal Q47377 http://www.proteinmodelportal.org/query/uniprot/Q47377 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17928292 http://www.ncbi.nlm.nih.gov/pubmed/17928292 PubMed 8626063 http://www.ncbi.nlm.nih.gov/pubmed/8626063 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000638031 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000638031 RefSeq YP_588462 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_588462 STRING 511145.b4544 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4544&targetmode=cogs STRING COG0697 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0697&targetmode=cogs TCDB 2.A.7.22 http://www.tcdb.org/search/result.php?tc=2.A.7.22 UniProtKB ARNE_ECOLI http://www.uniprot.org/uniprot/ARNE_ECOLI UniProtKB-AC Q47377 http://www.uniprot.org/uniprot/Q47377 charge swissprot:ARNE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARNE_ECOLI eggNOG COG0697 http://eggnogapi.embl.de/nog_data/html/tree/COG0697 eggNOG ENOG41060GT http://eggnogapi.embl.de/nog_data/html/tree/ENOG41060GT epestfind swissprot:ARNE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARNE_ECOLI garnier swissprot:ARNE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARNE_ECOLI helixturnhelix swissprot:ARNE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARNE_ECOLI hmoment swissprot:ARNE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARNE_ECOLI iep swissprot:ARNE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARNE_ECOLI inforesidue swissprot:ARNE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARNE_ECOLI octanol swissprot:ARNE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARNE_ECOLI pepcoil swissprot:ARNE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARNE_ECOLI pepdigest swissprot:ARNE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARNE_ECOLI pepinfo swissprot:ARNE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARNE_ECOLI pepnet swissprot:ARNE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARNE_ECOLI pepstats swissprot:ARNE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARNE_ECOLI pepwheel swissprot:ARNE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARNE_ECOLI pepwindow swissprot:ARNE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARNE_ECOLI sigcleave swissprot:ARNE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARNE_ECOLI ## Database ID URL or Descriptions # BioGrid 4262918 172 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG13783 yddL # GO_component GO:0016020 membrane; IEA:InterPro. # GO_function GO:0015288 porin activity; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0022857 transmembrane transporter activity # Gene3D 2.40.160.10 -; 1. # InterPro IPR001702 Porin_Gram-ve # InterPro IPR001897 Porin_gammaproteobac # InterPro IPR023614 Porin_dom # Organism YDDL_ECOLI Escherichia coli (strain K12) # PATRIC 48662251 VBIEscCol107702_1487 # PIR C64900 C64900 # PRINTS PR00183 ECOLIPORIN # Pfam PF00267 Porin_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDDL_ECOLI Putative uncharacterized protein YddL # RefSeq WP_000768384 NZ_LN832404.1 BLAST swissprot:YDDL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDDL_ECOLI BioCyc ECOL316407:JW1468-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1468-MONOMER BioCyc EcoCyc:G6773-MONOMER http://biocyc.org/getid?id=EcoCyc:G6773-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG13783 http://www.ecogene.org/geneInfo.php?eg_id=EG13783 EnsemblBacteria BAA15121 http://www.ensemblgenomes.org/id/BAA15121 EnsemblBacteria BAA15121 http://www.ensemblgenomes.org/id/BAA15121 EnsemblBacteria BAA15121 http://www.ensemblgenomes.org/id/BAA15121 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0015288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015288 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 Gene3D 2.40.160.10 http://www.cathdb.info/version/latest/superfamily/2.40.160.10 IntAct P77519 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77519* InterPro IPR001702 http://www.ebi.ac.uk/interpro/entry/IPR001702 InterPro IPR001897 http://www.ebi.ac.uk/interpro/entry/IPR001897 InterPro IPR023614 http://www.ebi.ac.uk/interpro/entry/IPR023614 KEGG_Gene ecj:JW1468 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1468 OMA GLCWSEI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GLCWSEI PRINTS PR00183 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00183 PSORT swissprot:YDDL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDDL_ECOLI PSORT-B swissprot:YDDL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDDL_ECOLI PSORT2 swissprot:YDDL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDDL_ECOLI Pfam PF00267 http://pfam.xfam.org/family/PF00267 Phobius swissprot:YDDL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDDL_ECOLI ProteinModelPortal P77519 http://www.proteinmodelportal.org/query/uniprot/P77519 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000768384 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000768384 SMR P77519 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77519 STRING 316407.1742405 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.1742405&targetmode=cogs UniProtKB YDDL_ECOLI http://www.uniprot.org/uniprot/YDDL_ECOLI UniProtKB-AC P77519 http://www.uniprot.org/uniprot/P77519 charge swissprot:YDDL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDDL_ECOLI epestfind swissprot:YDDL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDDL_ECOLI garnier swissprot:YDDL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDDL_ECOLI helixturnhelix swissprot:YDDL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDDL_ECOLI hmoment swissprot:YDDL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDDL_ECOLI iep swissprot:YDDL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDDL_ECOLI inforesidue swissprot:YDDL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDDL_ECOLI octanol swissprot:YDDL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDDL_ECOLI pepcoil swissprot:YDDL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDDL_ECOLI pepdigest swissprot:YDDL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDDL_ECOLI pepinfo swissprot:YDDL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDDL_ECOLI pepnet swissprot:YDDL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDDL_ECOLI pepstats swissprot:YDDL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDDL_ECOLI pepwheel swissprot:YDDL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDDL_ECOLI pepwindow swissprot:YDDL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDDL_ECOLI sigcleave swissprot:YDDL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDDL_ECOLI ## Database ID URL or Descriptions # BRENDA 2.7.13 2026 # BioGrid 4261905 10 # CATALYTIC ACTIVITY CREC_ECOLI ATP + protein L-histidine = ADP + protein N- phospho-L-histidine. # CDD cd06225 HAMP # EcoGene EG10730 creC # FUNCTION CREC_ECOLI Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. CreC may function as a membrane- associated protein kinase that phosphorylates CreB in response to environmental signals. CreC can also phosphorylate PhoB. {ECO 0000269|PubMed 15522865, ECO 0000269|PubMed 2228961}. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IDA:EcoCyc. # GO_function GO:0000155 phosphorelay sensor kinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0000160 phosphorelay signal transduction system; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005622 intracellular # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0007165 signal transduction # Gene3D 1.10.287.130 -; 1. # Gene3D 3.30.565.10 -; 1. # IntAct P08401 5 # InterPro IPR003594 HATPase_C # InterPro IPR003660 HAMP_dom # InterPro IPR003661 HisK_dim/P # InterPro IPR004358 Sig_transdc_His_kin-like_C # InterPro IPR005467 His_kinase_dom # InterPro IPR029151 Sensor-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01001 Protein kinases # KEGG_Brite ko02022 M00449 CreC-CreB (phosphate regulation) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # Organism CREC_ECOLI Escherichia coli (strain K12) # PATRIC 32124416 VBIEscCol129921_4548 # PIR S56623 RGECFM # PRINTS PR00344 BCTRLSENSOR # PROSITE PS50109 HIS_KIN # PROSITE PS50885 HAMP # PTM CREC_ECOLI Autophosphorylated. # Pfam PF00512 HisKA # Pfam PF00672 HAMP # Pfam PF02518 HATPase_c # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CREC_ECOLI Sensor protein CreC # RefSeq NP_418816 NC_000913.3 # RefSeq WP_001219559 NZ_LN832404.1 # SIMILARITY Contains 1 HAMP domain. {ECO:0000255|PROSITE- ProRule PRU00102}. # SIMILARITY Contains 1 histidine kinase domain. {ECO:0000255|PROSITE-ProRule PRU00107}. # SMART SM00304 HAMP # SMART SM00387 HATPase_c # SMART SM00388 HisKA # SUBCELLULAR LOCATION CREC_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF103190 SSF103190 # SUPFAM SSF47384 SSF47384 # SUPFAM SSF55874 SSF55874 # eggNOG COG0642 LUCA # eggNOG ENOG4105EB3 Bacteria BLAST swissprot:CREC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CREC_ECOLI BioCyc ECOL316407:JW4362-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4362-MONOMER BioCyc EcoCyc:CREC-MONOMER http://biocyc.org/getid?id=EcoCyc:CREC-MONOMER COG COG0642 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0642 DIP DIP-9319N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9319N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M410104200 http://dx.doi.org/10.1074/jbc.M410104200 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1111/j.1365-2958.1988.tb00012.x http://dx.doi.org/10.1111/j.1365-2958.1988.tb00012.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.13.3 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.13.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M13608 http://www.ebi.ac.uk/ena/data/view/M13608 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL Y00538 http://www.ebi.ac.uk/ena/data/view/Y00538 ENZYME 2.7.13.3 http://enzyme.expasy.org/EC/2.7.13.3 EchoBASE EB0723 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0723 EcoGene EG10730 http://www.ecogene.org/geneInfo.php?eg_id=EG10730 EnsemblBacteria AAC77352 http://www.ensemblgenomes.org/id/AAC77352 EnsemblBacteria AAC77352 http://www.ensemblgenomes.org/id/AAC77352 EnsemblBacteria BAE78388 http://www.ensemblgenomes.org/id/BAE78388 EnsemblBacteria BAE78388 http://www.ensemblgenomes.org/id/BAE78388 EnsemblBacteria BAE78388 http://www.ensemblgenomes.org/id/BAE78388 EnsemblBacteria b4399 http://www.ensemblgenomes.org/id/b4399 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0000155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000155 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 Gene3D 1.10.287.130 http://www.cathdb.info/version/latest/superfamily/1.10.287.130 Gene3D 3.30.565.10 http://www.cathdb.info/version/latest/superfamily/3.30.565.10 GeneID 948609 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948609 HOGENOM HOG000211121 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000211121&db=HOGENOM6 InParanoid P08401 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P08401 IntAct P08401 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P08401* IntEnz 2.7.13.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.13.3 InterPro IPR003594 http://www.ebi.ac.uk/interpro/entry/IPR003594 InterPro IPR003660 http://www.ebi.ac.uk/interpro/entry/IPR003660 InterPro IPR003661 http://www.ebi.ac.uk/interpro/entry/IPR003661 InterPro IPR004358 http://www.ebi.ac.uk/interpro/entry/IPR004358 InterPro IPR005467 http://www.ebi.ac.uk/interpro/entry/IPR005467 InterPro IPR029151 http://www.ebi.ac.uk/interpro/entry/IPR029151 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01001 http://www.genome.jp/dbget-bin/www_bget?ko01001 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW4362 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4362 KEGG_Gene eco:b4399 http://www.genome.jp/dbget-bin/www_bget?eco:b4399 KEGG_Orthology KO:K07641 http://www.genome.jp/dbget-bin/www_bget?KO:K07641 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 MINT MINT-1307740 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1307740 OMA IRWNNEI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IRWNNEI PRINTS PR00344 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00344 PROSITE PS50109 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50109 PROSITE PS50885 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50885 PSORT swissprot:CREC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CREC_ECOLI PSORT-B swissprot:CREC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CREC_ECOLI PSORT2 swissprot:CREC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CREC_ECOLI Pfam PF00512 http://pfam.xfam.org/family/PF00512 Pfam PF00672 http://pfam.xfam.org/family/PF00672 Pfam PF02518 http://pfam.xfam.org/family/PF02518 Phobius swissprot:CREC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CREC_ECOLI PhylomeDB P08401 http://phylomedb.org/?seqid=P08401 ProteinModelPortal P08401 http://www.proteinmodelportal.org/query/uniprot/P08401 PubMed 15522865 http://www.ncbi.nlm.nih.gov/pubmed/15522865 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2228961 http://www.ncbi.nlm.nih.gov/pubmed/2228961 PubMed 2835585 http://www.ncbi.nlm.nih.gov/pubmed/2835585 PubMed 3531171 http://www.ncbi.nlm.nih.gov/pubmed/3531171 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418816 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418816 RefSeq WP_001219559 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001219559 SMART SM00304 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00304 SMART SM00387 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00387 SMART SM00388 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00388 SMR P08401 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P08401 STRING 511145.b4399 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4399&targetmode=cogs STRING COG0642 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0642&targetmode=cogs SUPFAM SSF103190 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103190 SUPFAM SSF47384 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47384 SUPFAM SSF55874 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55874 UniProtKB CREC_ECOLI http://www.uniprot.org/uniprot/CREC_ECOLI UniProtKB-AC P08401 http://www.uniprot.org/uniprot/P08401 charge swissprot:CREC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CREC_ECOLI eggNOG COG0642 http://eggnogapi.embl.de/nog_data/html/tree/COG0642 eggNOG ENOG4105EB3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EB3 epestfind swissprot:CREC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CREC_ECOLI garnier swissprot:CREC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CREC_ECOLI helixturnhelix swissprot:CREC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CREC_ECOLI hmoment swissprot:CREC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CREC_ECOLI iep swissprot:CREC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CREC_ECOLI inforesidue swissprot:CREC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CREC_ECOLI octanol swissprot:CREC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CREC_ECOLI pepcoil swissprot:CREC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CREC_ECOLI pepdigest swissprot:CREC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CREC_ECOLI pepinfo swissprot:CREC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CREC_ECOLI pepnet swissprot:CREC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CREC_ECOLI pepstats swissprot:CREC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CREC_ECOLI pepwheel swissprot:CREC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CREC_ECOLI pepwindow swissprot:CREC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CREC_ECOLI sigcleave swissprot:CREC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CREC_ECOLI ## Database ID URL or Descriptions # BioGrid 4259689 200 # EcoGene EG13574 wcaF # GO_function GO:0016746 transferase activity, transferring acyl groups; IEA:UniProtKB-KW. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0045228 slime layer polysaccharide biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # InterPro IPR001451 Hexapep # InterPro IPR011004 Trimer_LpxA-like # InterPro IPR018357 Hexapep_transf_CS # InterPro IPR024005 Colanic_acid_synth_WcaF # KEGG_Brite ko01000 Enzymes # Organism WCAF_ECOLI Escherichia coli (strain K12) # PATHWAY WCAF_ECOLI Slime biogenesis; slime polysaccharide biosynthesis. # PATRIC 32119441 VBIEscCol129921_2131 # PIR E64971 E64971 # PROSITE PS00101 HEXAPEP_TRANSFERASES # Pfam PF00132 Hexapep # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName WCAF_ECOLI Putative colanic acid biosynthesis acetyltransferase WcaF # RefSeq NP_416558 NC_000913.3 # RefSeq WP_001153547 NZ_LN832404.1 # SIMILARITY Belongs to the transferase hexapeptide repeat family. {ECO 0000305}. # SUPFAM SSF51161 SSF51161 # TIGRFAMs TIGR04008 WcaF # eggNOG COG0110 LUCA # eggNOG ENOG4108Z90 Bacteria BLAST swissprot:WCAF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:WCAF_ECOLI BioCyc ECOL316407:JW2039-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2039-MONOMER BioCyc EcoCyc:G7099-MONOMER http://biocyc.org/getid?id=EcoCyc:G7099-MONOMER COG COG0110 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0110 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U38473 http://www.ebi.ac.uk/ena/data/view/U38473 ENZYME 2.3.1.- http://enzyme.expasy.org/EC/2.3.1.- EchoBASE EB3344 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3344 EcoGene EG13574 http://www.ecogene.org/geneInfo.php?eg_id=EG13574 EnsemblBacteria AAC75115 http://www.ensemblgenomes.org/id/AAC75115 EnsemblBacteria AAC75115 http://www.ensemblgenomes.org/id/AAC75115 EnsemblBacteria BAA15910 http://www.ensemblgenomes.org/id/BAA15910 EnsemblBacteria BAA15910 http://www.ensemblgenomes.org/id/BAA15910 EnsemblBacteria BAA15910 http://www.ensemblgenomes.org/id/BAA15910 EnsemblBacteria b2054 http://www.ensemblgenomes.org/id/b2054 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GO_process GO:0045228 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045228 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 946578 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946578 HOGENOM HOG000049439 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000049439&db=HOGENOM6 InParanoid P0ACD2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACD2 IntAct P0ACD2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACD2* IntEnz 2.3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1 InterPro IPR001451 http://www.ebi.ac.uk/interpro/entry/IPR001451 InterPro IPR011004 http://www.ebi.ac.uk/interpro/entry/IPR011004 InterPro IPR018357 http://www.ebi.ac.uk/interpro/entry/IPR018357 InterPro IPR024005 http://www.ebi.ac.uk/interpro/entry/IPR024005 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2039 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2039 KEGG_Gene eco:b2054 http://www.genome.jp/dbget-bin/www_bget?eco:b2054 KEGG_Orthology KO:K03818 http://www.genome.jp/dbget-bin/www_bget?KO:K03818 OMA CWGSPCR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CWGSPCR PROSITE PS00101 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00101 PSORT swissprot:WCAF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:WCAF_ECOLI PSORT-B swissprot:WCAF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:WCAF_ECOLI PSORT2 swissprot:WCAF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:WCAF_ECOLI Pfam PF00132 http://pfam.xfam.org/family/PF00132 Phobius swissprot:WCAF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:WCAF_ECOLI PhylomeDB P0ACD2 http://phylomedb.org/?seqid=P0ACD2 ProteinModelPortal P0ACD2 http://www.proteinmodelportal.org/query/uniprot/P0ACD2 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8759852 http://www.ncbi.nlm.nih.gov/pubmed/8759852 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416558 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416558 RefSeq WP_001153547 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001153547 SMR P0ACD2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACD2 STRING 511145.b2054 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2054&targetmode=cogs STRING COG0110 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0110&targetmode=cogs SUPFAM SSF51161 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51161 TIGRFAMs TIGR04008 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR04008 UniProtKB WCAF_ECOLI http://www.uniprot.org/uniprot/WCAF_ECOLI UniProtKB-AC P0ACD2 http://www.uniprot.org/uniprot/P0ACD2 charge swissprot:WCAF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:WCAF_ECOLI eggNOG COG0110 http://eggnogapi.embl.de/nog_data/html/tree/COG0110 eggNOG ENOG4108Z90 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Z90 epestfind swissprot:WCAF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:WCAF_ECOLI garnier swissprot:WCAF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:WCAF_ECOLI helixturnhelix swissprot:WCAF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:WCAF_ECOLI hmoment swissprot:WCAF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:WCAF_ECOLI iep swissprot:WCAF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:WCAF_ECOLI inforesidue swissprot:WCAF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:WCAF_ECOLI octanol swissprot:WCAF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:WCAF_ECOLI pepcoil swissprot:WCAF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:WCAF_ECOLI pepdigest swissprot:WCAF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:WCAF_ECOLI pepinfo swissprot:WCAF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:WCAF_ECOLI pepnet swissprot:WCAF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:WCAF_ECOLI pepstats swissprot:WCAF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:WCAF_ECOLI pepwheel swissprot:WCAF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:WCAF_ECOLI pepwindow swissprot:WCAF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:WCAF_ECOLI sigcleave swissprot:WCAF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:WCAF_ECOLI ## Database ID URL or Descriptions # AltName TDP-Fuc4NAc lipid II Fuc4NAc transferase # AltName WECF_ECOLI 4-alpha-L-fucosyltransferase # BioGrid 4262106 182 # CATALYTIC ACTIVITY dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + N-acetyl-beta-D-mannosaminouronyl-(1->4)-N-acetyl-alpha-D- glucosaminyl-diphospho-ditrans,octacis-undecaprenol = dTDP + 4- acetamido-4,6-dideoxy-alpha-D-galactosyl-(1->4)-N-acetyl-beta-D- mannosaminouronyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho- ditrans,octacis-undecaprenol. {ECO:0000269|PubMed 11673418}. # CAZy GT56 Glycosyltransferase Family 56 # EcoGene EG14320 rffT # FUNCTION WECF_ECOLI Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis. {ECO 0000269|PubMed 11673418}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_function GO:0008417 fucosyltransferase activity; IDA:EcoCyc. # GO_function GO:0102031 4-acetamido-4,6-dideoxy-D-galactose transferase activity; IEA:UniProtKB-EC. # GO_process GO:0009246 enterobacterial common antigen biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # HAMAP MF_01002 WecF_RffT # IntAct P56258 3 # InterPro IPR009993 WecF # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01003 Glycosyltransferases # Organism WECF_ECOLI Escherichia coli (strain K12) # PATHWAY WECF_ECOLI Bacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis. # PATRIC 32123079 VBIEscCol129921_3909 # Pfam PF07429 Glyco_transf_56 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TDP-N-acetylfucosamine lipid II N-acetylfucosaminyltransferase # RefSeq WP_000217234 NZ_LN832404.1 # RefSeq YP_026257 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA67593.1; Type=Frameshift; Positions=60, 67, 327, 354; Evidence={ECO 0000305}; # SIMILARITY Belongs to the glycosyltransferase 56 family. {ECO 0000305}. # SUBCELLULAR LOCATION WECF_ECOLI Cell inner membrane {ECO 0000305}; Peripheral membrane protein {ECO 0000305}. # eggNOG ENOG4105F18 Bacteria # eggNOG ENOG410XT9P LUCA BLAST swissprot:WECF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:WECF_ECOLI BioCyc ECOL316407:JW5596-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5596-MONOMER BioCyc EcoCyc:G7800-MONOMER http://biocyc.org/getid?id=EcoCyc:G7800-MONOMER BioCyc MetaCyc:G7800-MONOMER http://biocyc.org/getid?id=MetaCyc:G7800-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.183.22.6509-6516.2001 http://dx.doi.org/10.1128/JB.183.22.6509-6516.2001 EC_number EC:2.4.1.325 http://www.genome.jp/dbget-bin/www_bget?EC:2.4.1.325 EMBL AF375882 http://www.ebi.ac.uk/ena/data/view/AF375882 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.4.1.325 http://enzyme.expasy.org/EC/2.4.1.325 EchoBASE EB4066 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4066 EcoGene EG14320 http://www.ecogene.org/geneInfo.php?eg_id=EG14320 EnsemblBacteria AAT48215 http://www.ensemblgenomes.org/id/AAT48215 EnsemblBacteria AAT48215 http://www.ensemblgenomes.org/id/AAT48215 EnsemblBacteria BAE77505 http://www.ensemblgenomes.org/id/BAE77505 EnsemblBacteria BAE77505 http://www.ensemblgenomes.org/id/BAE77505 EnsemblBacteria BAE77505 http://www.ensemblgenomes.org/id/BAE77505 EnsemblBacteria b4481 http://www.ensemblgenomes.org/id/b4481 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0008417 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008417 GO_function GO:0102031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0102031 GO_process GO:0009246 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009246 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 2847677 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2847677 HAMAP MF_01002 http://hamap.expasy.org/unirule/MF_01002 HOGENOM HOG000249654 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000249654&db=HOGENOM6 IntAct P56258 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P56258* IntEnz 2.4.1.325 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.1.325 InterPro IPR009993 http://www.ebi.ac.uk/interpro/entry/IPR009993 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01003 http://www.genome.jp/dbget-bin/www_bget?ko01003 KEGG_Gene ecj:JW5596 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5596 KEGG_Gene eco:b4481 http://www.genome.jp/dbget-bin/www_bget?eco:b4481 KEGG_Orthology KO:K12582 http://www.genome.jp/dbget-bin/www_bget?KO:K12582 OMA VIVPMGY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VIVPMGY PSORT swissprot:WECF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:WECF_ECOLI PSORT-B swissprot:WECF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:WECF_ECOLI PSORT2 swissprot:WECF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:WECF_ECOLI Pfam PF07429 http://pfam.xfam.org/family/PF07429 Phobius swissprot:WECF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:WECF_ECOLI ProteinModelPortal P56258 http://www.proteinmodelportal.org/query/uniprot/P56258 PubMed 11673418 http://www.ncbi.nlm.nih.gov/pubmed/11673418 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000217234 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000217234 RefSeq YP_026257 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026257 STRING 511145.b4481 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4481&targetmode=cogs UniProtKB WECF_ECOLI http://www.uniprot.org/uniprot/WECF_ECOLI UniProtKB-AC P56258 http://www.uniprot.org/uniprot/P56258 charge swissprot:WECF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:WECF_ECOLI eggNOG ENOG4105F18 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F18 eggNOG ENOG410XT9P http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XT9P epestfind swissprot:WECF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:WECF_ECOLI garnier swissprot:WECF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:WECF_ECOLI helixturnhelix swissprot:WECF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:WECF_ECOLI hmoment swissprot:WECF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:WECF_ECOLI iep swissprot:WECF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:WECF_ECOLI inforesidue swissprot:WECF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:WECF_ECOLI octanol swissprot:WECF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:WECF_ECOLI pepcoil swissprot:WECF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:WECF_ECOLI pepdigest swissprot:WECF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:WECF_ECOLI pepinfo swissprot:WECF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:WECF_ECOLI pepnet swissprot:WECF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:WECF_ECOLI pepstats swissprot:WECF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:WECF_ECOLI pepwheel swissprot:WECF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:WECF_ECOLI pepwindow swissprot:WECF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:WECF_ECOLI sigcleave swissprot:WECF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:WECF_ECOLI ## Database ID URL or Descriptions # AltName ANSP_ECOLI L-asparagine transport protein # BioGrid 4260199 8 # EcoGene EG13776 ansP # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0015179 L-amino acid transmembrane transporter activity; IBA:GO_Central. # GO_function GO:0015297 antiporter activity; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # InterPro IPR002293 AA/rel_permease1 # InterPro IPR004840 Amoino_acid_permease_CS # InterPro IPR004841 AA-permease/SLC12A_dom # KEGG_Brite ko02000 Transporters # Organism ANSP_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11785 PTHR11785 # PATRIC 32118198 VBIEscCol129921_1519 # PIRSF PIRSF006060 AA_transporter # PROSITE PS00218 AMINO_ACID_PERMEASE_1 # Pfam PF00324 AA_permease # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ANSP_ECOLI L-asparagine permease # RefSeq NP_415970 NC_000913.3 # RefSeq WP_001300590 NZ_LN832404.1 # SIMILARITY Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family. {ECO 0000305}. # SUBCELLULAR LOCATION ANSP_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # TCDB 2.A.3.1.24 the amino acid-polyamine-organocation (apc) family # eggNOG COG1113 LUCA # eggNOG ENOG4105C85 Bacteria BLAST swissprot:ANSP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ANSP_ECOLI BioCyc ECOL316407:JW5234-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5234-MONOMER BioCyc EcoCyc:ANSP-MONOMER http://biocyc.org/getid?id=EcoCyc:ANSP-MONOMER COG COG1113 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1113 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3538 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3538 EcoGene EG13776 http://www.ecogene.org/geneInfo.php?eg_id=EG13776 EnsemblBacteria AAC74535 http://www.ensemblgenomes.org/id/AAC74535 EnsemblBacteria AAC74535 http://www.ensemblgenomes.org/id/AAC74535 EnsemblBacteria BAA15086 http://www.ensemblgenomes.org/id/BAA15086 EnsemblBacteria BAA15086 http://www.ensemblgenomes.org/id/BAA15086 EnsemblBacteria BAA15086 http://www.ensemblgenomes.org/id/BAA15086 EnsemblBacteria b1453 http://www.ensemblgenomes.org/id/b1453 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015179 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015179 GO_function GO:0015297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015297 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GeneID 946019 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946019 HOGENOM HOG000261847 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261847&db=HOGENOM6 InParanoid P77610 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77610 InterPro IPR002293 http://www.ebi.ac.uk/interpro/entry/IPR002293 InterPro IPR004840 http://www.ebi.ac.uk/interpro/entry/IPR004840 InterPro IPR004841 http://www.ebi.ac.uk/interpro/entry/IPR004841 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5234 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5234 KEGG_Gene eco:b1453 http://www.genome.jp/dbget-bin/www_bget?eco:b1453 KEGG_Orthology KO:K11738 http://www.genome.jp/dbget-bin/www_bget?KO:K11738 OMA YNTSHSI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YNTSHSI PANTHER PTHR11785 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11785 PROSITE PS00218 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00218 PSORT swissprot:ANSP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ANSP_ECOLI PSORT-B swissprot:ANSP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ANSP_ECOLI PSORT2 swissprot:ANSP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ANSP_ECOLI Pfam PF00324 http://pfam.xfam.org/family/PF00324 Phobius swissprot:ANSP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ANSP_ECOLI PhylomeDB P77610 http://phylomedb.org/?seqid=P77610 ProteinModelPortal P77610 http://www.proteinmodelportal.org/query/uniprot/P77610 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415970 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415970 RefSeq WP_001300590 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300590 STRING 511145.b1453 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1453&targetmode=cogs STRING COG1113 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1113&targetmode=cogs TCDB 2.A.3.1.24 http://www.tcdb.org/search/result.php?tc=2.A.3.1.24 UniProtKB ANSP_ECOLI http://www.uniprot.org/uniprot/ANSP_ECOLI UniProtKB-AC P77610 http://www.uniprot.org/uniprot/P77610 charge swissprot:ANSP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ANSP_ECOLI eggNOG COG1113 http://eggnogapi.embl.de/nog_data/html/tree/COG1113 eggNOG ENOG4105C85 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C85 epestfind swissprot:ANSP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ANSP_ECOLI garnier swissprot:ANSP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ANSP_ECOLI helixturnhelix swissprot:ANSP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ANSP_ECOLI hmoment swissprot:ANSP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ANSP_ECOLI iep swissprot:ANSP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ANSP_ECOLI inforesidue swissprot:ANSP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ANSP_ECOLI octanol swissprot:ANSP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ANSP_ECOLI pepcoil swissprot:ANSP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ANSP_ECOLI pepdigest swissprot:ANSP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ANSP_ECOLI pepinfo swissprot:ANSP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ANSP_ECOLI pepnet swissprot:ANSP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ANSP_ECOLI pepstats swissprot:ANSP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ANSP_ECOLI pepwheel swissprot:ANSP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ANSP_ECOLI pepwindow swissprot:ANSP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ANSP_ECOLI sigcleave swissprot:ANSP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ANSP_ECOLI ## Database ID URL or Descriptions # BioGrid 4263408 36 # DOMAIN RS5_ECOLI The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity. # EcoGene EG10904 rpsE # FUNCTION RS5_ECOLI Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. {ECO 0000269|PubMed 15652481}. # FUNCTION RS5_ECOLI The physical location of this protein suggests it may also play a role in mRNA unwinding by the ribosome, possibly by forming part of a processivity clamp. {ECO 0000269|PubMed 15652481}. # FUNCTION RS5_ECOLI With S4 and S12 plays an important role in translational accuracy. Many suppressors of streptomycin-dependent mutants of protein S12 are found in this protein, some but not all of which decrease translational accuracy (ram, ribosomal ambiguity mutations). {ECO 0000269|PubMed 15652481}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0022627 cytosolic small ribosomal subunit; IDA:EcoCyc. # GO_function GO:0003735 structural constituent of ribosome; IBA:GO_Central. # GO_function GO:0019843 rRNA binding; IEA:UniProtKB-HAMAP. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GO_process GO:1990145 maintenance of translational fidelity; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_function GO:0019843 rRNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.30.160.20 -; 1. # Gene3D 3.30.230.10 -; 1. # HAMAP MF_01307_B Ribosomal_S5_B # INTERACTION RS5_ECOLI P30850 rnb; NbExp=2; IntAct=EBI-543949, EBI-557325; P0ADZ0 rplW; NbExp=2; IntAct=EBI-543949, EBI-542264; # IntAct P0A7W1 190 # InterPro IPR000851 Ribosomal_S5 # InterPro IPR005324 Ribosomal_S5_C # InterPro IPR005712 Ribosomal_S5_bac-type # InterPro IPR013810 Ribosomal_S5_N # InterPro IPR014720 dsRBD_dom # InterPro IPR014721 Ribosomal_S5_D2-typ_fold_subgr # InterPro IPR018192 Ribosomal_S5_N_CS # InterPro IPR020568 Ribosomal_S5_D2-typ_fold # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 M00179 Ribosome, archaea # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=17514.8; Method=MALDI; Range=2-167; Evidence={ECO:0000269|PubMed 10094780}; # MISCELLANEOUS RS5_ECOLI Altered S5 proteins have been identified in a number of mutants. Some mutations in S5 have been shown to increase translational error frequencies. # MISCELLANEOUS RS5_ECOLI Some mutants in this protein can partially suppress an alanyl-tRNA synthetase mutant. # Organism RS5_ECOLI Escherichia coli (strain K12) # PANTHER PTHR13718 PTHR13718 # PATRIC 32122038 VBIEscCol129921_3396 # PDB 1EG0 EM; 11.50 A; B=1-148 # PDB 1M5G Model; -; E=10-159 # PDB 2YKR EM; 9.80 A; E=10-159 # PDB 3J9Y EM; 3.90 A; e=1-167 # PDB 3J9Z EM; 3.60 A; SE=2-167 # PDB 3JA1 EM; 3.60 A; SE=2-167 # PDB 3JBU EM; 3.64 A; E=1-167 # PDB 3JBV EM; 3.32 A; E=1-167 # PDB 3JCD EM; 3.70 A; e=1-167 # PDB 3JCE EM; 3.20 A; e=1-167 # PDB 3JCJ EM; 3.70 A; k=1-167 # PDB 3JCN EM; 4.60 A; f=1-159 # PDB 4A2I EM; 16.50 A; E=10-159 # PDB 4ADV EM; 13.50 A; E=2-167 # PDB 4U1U X-ray; 2.95 A; AE/CE=10-159 # PDB 4U1V X-ray; 3.00 A; AE/CE=10-159 # PDB 4U20 X-ray; 2.90 A; AE/CE=10-159 # PDB 4U24 X-ray; 2.90 A; AE/CE=10-159 # PDB 4U25 X-ray; 2.90 A; AE/CE=10-159 # PDB 4U26 X-ray; 2.80 A; AE/CE=10-159 # PDB 4U27 X-ray; 2.80 A; AE/CE=10-159 # PDB 4V47 EM; 12.30 A; BE=2-167 # PDB 4V48 EM; 11.50 A; BE=2-167 # PDB 4V4H X-ray; 3.46 A; AE/CE=1-167 # PDB 4V4Q X-ray; 3.46 A; AE/CE=2-167 # PDB 4V4V EM; 15.00 A; AE=10-157 # PDB 4V4W EM; 15.00 A; AE=10-157 # PDB 4V50 X-ray; 3.22 A; AE/CE=2-167 # PDB 4V52 X-ray; 3.21 A; AE/CE=2-167 # PDB 4V53 X-ray; 3.54 A; AE/CE=2-167 # PDB 4V54 X-ray; 3.30 A; AE/CE=2-167 # PDB 4V55 X-ray; 4.00 A; AE/CE=2-167 # PDB 4V56 X-ray; 3.93 A; AE/CE=2-167 # PDB 4V57 X-ray; 3.50 A; AE/CE=2-167 # PDB 4V5B X-ray; 3.74 A; BE/DE=2-167 # PDB 4V5H EM; 5.80 A; AE=10-159 # PDB 4V5Y X-ray; 4.45 A; AE/CE=2-167 # PDB 4V64 X-ray; 3.50 A; AE/CE=2-167 # PDB 4V65 EM; 9.00 A; AS=1-159 # PDB 4V66 EM; 9.00 A; AS=1-159 # PDB 4V69 EM; 6.70 A; AE=10-159 # PDB 4V6C X-ray; 3.19 A; AE/CE=1-167 # PDB 4V6D X-ray; 3.81 A; AE/CE=1-167 # PDB 4V6E X-ray; 3.71 A; AE/CE=1-167 # PDB 4V6K EM; 8.25 A; BI=1-167 # PDB 4V6L EM; 13.20 A; AI=1-167 # PDB 4V6M EM; 7.10 A; AE=2-167 # PDB 4V6N EM; 12.10 A; BH=2-167 # PDB 4V6O EM; 14.70 A; AH=2-167 # PDB 4V6P EM; 13.50 A; AH=2-167 # PDB 4V6Q EM; 11.50 A; AH=2-167 # PDB 4V6R EM; 11.50 A; AH=2-167 # PDB 4V6S EM; 13.10 A; BG=2-167 # PDB 4V6T EM; 8.30 A; AE=10-159 # PDB 4V6V EM; 9.80 A; AE=2-167 # PDB 4V6Y EM; 12.00 A; AE=10-159 # PDB 4V6Z EM; 12.00 A; AE=10-159 # PDB 4V70 EM; 17.00 A; AE=10-159 # PDB 4V71 EM; 20.00 A; AE=10-159 # PDB 4V72 EM; 13.00 A; AE=10-159 # PDB 4V73 EM; 15.00 A; AE=10-159 # PDB 4V74 EM; 17.00 A; AE=10-159 # PDB 4V75 EM; 12.00 A; AE=10-159 # PDB 4V76 EM; 17.00 A; AE=10-159 # PDB 4V77 EM; 17.00 A; AE=10-159 # PDB 4V78 EM; 20.00 A; AE=10-159 # PDB 4V79 EM; 15.00 A; AE=10-159 # PDB 4V7A EM; 9.00 A; AE=10-159 # PDB 4V7B EM; 6.80 A; AE=1-167 # PDB 4V7C EM; 7.60 A; AE=2-167 # PDB 4V7D EM; 7.60 A; BE=2-167 # PDB 4V7I EM; 9.60 A; BE=1-167 # PDB 4V7S X-ray; 3.25 A; AE/CE=10-159 # PDB 4V7T X-ray; 3.19 A; AE/CE=10-159 # PDB 4V7U X-ray; 3.10 A; AE/CE=10-159 # PDB 4V7V X-ray; 3.29 A; AE/CE=10-159 # PDB 4V85 X-ray; 3.20 A; E=1-167 # PDB 4V89 X-ray; 3.70 A; AE=1-167 # PDB 4V9C X-ray; 3.30 A; AE/CE=1-167 # PDB 4V9D X-ray; 3.00 A; AE/BE=10-159 # PDB 4V9O X-ray; 2.90 A; BE/DE/FE/HE=1-167 # PDB 4V9P X-ray; 2.90 A; BE/DE/FE/HE=1-167 # PDB 4WF1 X-ray; 3.09 A; AE/CE=10-159 # PDB 4WOI X-ray; 3.00 A; AE/DE=1-167 # PDB 4WWW X-ray; 3.10 A; QE/XE=10-159 # PDB 4YBB X-ray; 2.10 A; AE/BE=10-164 # PDB 5AFI EM; 2.90 A; e=1-167 # PDB 5IQR EM; 3.00 A; j=1-167 # PDB 5IT8 X-ray; 3.12 A; AE/BE=10-164 # PDB 5J5B X-ray; 2.80 A; AE/BE=10-164 # PDB 5J7L X-ray; 3.00 A; AE/BE=10-164 # PDB 5J88 X-ray; 3.32 A; AE/BE=10-164 # PDB 5J8A X-ray; 3.10 A; AE/BE=10-164 # PDB 5J91 X-ray; 2.96 A; AE/BE=10-164 # PDB 5JC9 X-ray; 3.03 A; AE/BE=10-164 # PDB 5JTE EM; 3.60 A; AE=1-167 # PDB 5JU8 EM; 3.60 A; AE=1-167 # PDB 5KCR EM; 3.60 A; 1e=1-167 # PDB 5KCS EM; 3.90 A; 1e=1-167 # PDB 5KPS EM; 3.90 A; 10=1-167 # PDB 5KPV EM; 4.10 A; 9=1-167 # PDB 5KPW EM; 3.90 A; 9=1-167 # PDB 5KPX EM; 3.90 A; 9=1-167 # PDB 5L3P EM; 3.70 A; e=1-167 # PIR B65123 R3EC5 # PROSITE PS00585 RIBOSOMAL_S5 # PROSITE PS50881 S5_DSRBD # Pfam PF00333 Ribosomal_S5 # Pfam PF03719 Ribosomal_S5_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RS5_ECOLI 30S ribosomal protein S5 # RefSeq NP_417762 NC_000913.3 # RefSeq WP_000940121 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein S5P family. {ECO 0000305}. # SIMILARITY Contains 1 S5 DRBM domain. {ECO 0000305}. # SUBUNIT RS5_ECOLI Part of the 30S ribosomal subunit. Contacts proteins S4 and S8. With proteins S4 and S5 encircles the mRNA as it enters the ribosome, which may play a role in mRNA helicase processivity. Can be cross-linked to mRNA. # SUPFAM SSF54211 SSF54211 # TIGRFAMs TIGR01021 rpsE_bact # eggNOG COG0098 LUCA BLAST swissprot:RS5_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RS5_ECOLI BioCyc ECOL316407:JW3265-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3265-MONOMER BioCyc EcoCyc:EG10904-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10904-MONOMER BioCyc MetaCyc:EG10904-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10904-MONOMER COG COG0098 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0098 DIP DIP-10781N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10781N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1007/BF00333767 http://dx.doi.org/10.1007/BF00333767 DOI 10.1016/0014-5793(78)80059-3 http://dx.doi.org/10.1016/0014-5793(78)80059-3 DOI 10.1016/S0092-8674(03)00427-6 http://dx.doi.org/10.1016/S0092-8674(03)00427-6 DOI 10.1016/j.cell.2004.11.042 http://dx.doi.org/10.1016/j.cell.2004.11.042 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb841 http://dx.doi.org/10.1038/nsb841 DOI 10.1073/pnas.70.1.151 http://dx.doi.org/10.1073/pnas.70.1.151 DOI 10.1093/nar/11.9.2599 http://dx.doi.org/10.1093/nar/11.9.2599 DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X01563 http://www.ebi.ac.uk/ena/data/view/X01563 EchoBASE EB0897 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0897 EcoGene EG10904 http://www.ecogene.org/geneInfo.php?eg_id=EG10904 EnsemblBacteria AAC76328 http://www.ensemblgenomes.org/id/AAC76328 EnsemblBacteria AAC76328 http://www.ensemblgenomes.org/id/AAC76328 EnsemblBacteria BAE77988 http://www.ensemblgenomes.org/id/BAE77988 EnsemblBacteria BAE77988 http://www.ensemblgenomes.org/id/BAE77988 EnsemblBacteria BAE77988 http://www.ensemblgenomes.org/id/BAE77988 EnsemblBacteria b3303 http://www.ensemblgenomes.org/id/b3303 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0022627 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022627 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GO_process GO:1990145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990145 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.30.160.20 http://www.cathdb.info/version/latest/superfamily/3.30.160.20 Gene3D 3.30.230.10 http://www.cathdb.info/version/latest/superfamily/3.30.230.10 GeneID 947795 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947795 HAMAP MF_01307_B http://hamap.expasy.org/unirule/MF_01307_B HOGENOM HOG000072595 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000072595&db=HOGENOM6 InParanoid P0A7W1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7W1 IntAct P0A7W1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7W1* InterPro IPR000851 http://www.ebi.ac.uk/interpro/entry/IPR000851 InterPro IPR005324 http://www.ebi.ac.uk/interpro/entry/IPR005324 InterPro IPR005712 http://www.ebi.ac.uk/interpro/entry/IPR005712 InterPro IPR013810 http://www.ebi.ac.uk/interpro/entry/IPR013810 InterPro IPR014720 http://www.ebi.ac.uk/interpro/entry/IPR014720 InterPro IPR014721 http://www.ebi.ac.uk/interpro/entry/IPR014721 InterPro IPR018192 http://www.ebi.ac.uk/interpro/entry/IPR018192 InterPro IPR020568 http://www.ebi.ac.uk/interpro/entry/IPR020568 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW3265 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3265 KEGG_Gene eco:b3303 http://www.genome.jp/dbget-bin/www_bget?eco:b3303 KEGG_Orthology KO:K02988 http://www.genome.jp/dbget-bin/www_bget?KO:K02988 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 MINT MINT-6478202 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-6478202 OMA PHEQKGK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PHEQKGK PANTHER PTHR13718 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13718 PDB 1EG0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1EG0 PDB 1M5G http://www.ebi.ac.uk/pdbe-srv/view/entry/1M5G PDB 2YKR http://www.ebi.ac.uk/pdbe-srv/view/entry/2YKR PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 4A2I http://www.ebi.ac.uk/pdbe-srv/view/entry/4A2I PDB 4ADV http://www.ebi.ac.uk/pdbe-srv/view/entry/4ADV PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4V47 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V47 PDB 4V48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V48 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 1EG0 http://www.ebi.ac.uk/pdbsum/1EG0 PDBsum 1M5G http://www.ebi.ac.uk/pdbsum/1M5G PDBsum 2YKR http://www.ebi.ac.uk/pdbsum/2YKR PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 4A2I http://www.ebi.ac.uk/pdbsum/4A2I PDBsum 4ADV http://www.ebi.ac.uk/pdbsum/4ADV PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4V47 http://www.ebi.ac.uk/pdbsum/4V47 PDBsum 4V48 http://www.ebi.ac.uk/pdbsum/4V48 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PROSITE PS00585 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00585 PROSITE PS50881 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50881 PSORT swissprot:RS5_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RS5_ECOLI PSORT-B swissprot:RS5_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RS5_ECOLI PSORT2 swissprot:RS5_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RS5_ECOLI Pfam PF00333 http://pfam.xfam.org/family/PF00333 Pfam PF03719 http://pfam.xfam.org/family/PF03719 Phobius swissprot:RS5_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RS5_ECOLI PhylomeDB P0A7W1 http://phylomedb.org/?seqid=P0A7W1 ProteinModelPortal P0A7W1 http://www.proteinmodelportal.org/query/uniprot/P0A7W1 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 12244297 http://www.ncbi.nlm.nih.gov/pubmed/12244297 PubMed 12809609 http://www.ncbi.nlm.nih.gov/pubmed/12809609 PubMed 15652481 http://www.ncbi.nlm.nih.gov/pubmed/15652481 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1712292 http://www.ncbi.nlm.nih.gov/pubmed/1712292 PubMed 2138078 http://www.ncbi.nlm.nih.gov/pubmed/2138078 PubMed 363452 http://www.ncbi.nlm.nih.gov/pubmed/363452 PubMed 4273819 http://www.ncbi.nlm.nih.gov/pubmed/4273819 PubMed 4346030 http://www.ncbi.nlm.nih.gov/pubmed/4346030 PubMed 6222285 http://www.ncbi.nlm.nih.gov/pubmed/6222285 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417762 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417762 RefSeq WP_000940121 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000940121 SMR P0A7W1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7W1 STRING 511145.b3303 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3303&targetmode=cogs STRING COG0098 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0098&targetmode=cogs SUPFAM SSF54211 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54211 TIGRFAMs TIGR01021 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01021 UniProtKB RS5_ECOLI http://www.uniprot.org/uniprot/RS5_ECOLI UniProtKB-AC P0A7W1 http://www.uniprot.org/uniprot/P0A7W1 charge swissprot:RS5_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RS5_ECOLI eggNOG COG0098 http://eggnogapi.embl.de/nog_data/html/tree/COG0098 epestfind swissprot:RS5_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RS5_ECOLI garnier swissprot:RS5_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RS5_ECOLI helixturnhelix swissprot:RS5_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RS5_ECOLI hmoment swissprot:RS5_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RS5_ECOLI iep swissprot:RS5_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RS5_ECOLI inforesidue swissprot:RS5_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RS5_ECOLI octanol swissprot:RS5_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RS5_ECOLI pepcoil swissprot:RS5_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RS5_ECOLI pepdigest swissprot:RS5_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RS5_ECOLI pepinfo swissprot:RS5_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RS5_ECOLI pepnet swissprot:RS5_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RS5_ECOLI pepstats swissprot:RS5_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RS5_ECOLI pepwheel swissprot:RS5_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RS5_ECOLI pepwindow swissprot:RS5_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RS5_ECOLI sigcleave swissprot:RS5_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RS5_ECOLI ## Database ID URL or Descriptions # BioGrid 4260099 13 # EcoGene EG13892 pliG # FUNCTION PLIG_ECOLI Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium. {ECO 0000269|PubMed 20734102}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0042597 periplasmic space; IDA:EcoCyc. # GO_function GO:0060241 lysozyme inhibitor activity; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0030234 enzyme regulator activity # InterPro IPR007280 Peptidase_C_arc/bac # Organism PLIG_ECOLI Escherichia coli (strain K12) # PATRIC 32117600 VBIEscCol129921_1222 # PDB 4DXZ X-ray; 1.25 A; A=23-133 # PDB 4DY3 X-ray; 1.80 A; A/B=23-133 # PDB 4G9S X-ray; 0.95 A; B=23-133 # PIR G64863 G64863 # Pfam PF04151 PPC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PLIG_ECOLI Inhibitor of g-type lysozyme # RefSeq NP_415696 NC_000913.3 # RefSeq WP_000695215 NZ_LN832404.1 # SUBCELLULAR LOCATION PLIG_ECOLI Periplasm {ECO 0000269|PubMed 20734102}. # eggNOG ENOG41066UD Bacteria # eggNOG ENOG41129QS LUCA BLAST swissprot:PLIG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PLIG_ECOLI BioCyc ECOL316407:JW1167-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1167-MONOMER BioCyc EcoCyc:G6615-MONOMER http://biocyc.org/getid?id=EcoCyc:G6615-MONOMER DOI 10.1007/s00018-010-0507-3 http://dx.doi.org/10.1007/s00018-010-0507-3 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3651 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3651 EcoGene EG13892 http://www.ecogene.org/geneInfo.php?eg_id=EG13892 EnsemblBacteria AAC74262 http://www.ensemblgenomes.org/id/AAC74262 EnsemblBacteria AAC74262 http://www.ensemblgenomes.org/id/AAC74262 EnsemblBacteria BAA36012 http://www.ensemblgenomes.org/id/BAA36012 EnsemblBacteria BAA36012 http://www.ensemblgenomes.org/id/BAA36012 EnsemblBacteria BAA36012 http://www.ensemblgenomes.org/id/BAA36012 EnsemblBacteria b1178 http://www.ensemblgenomes.org/id/b1178 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0060241 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060241 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 GeneID 946963 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946963 HOGENOM HOG000269686 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000269686&db=HOGENOM6 IntAct P76002 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76002* InterPro IPR007280 http://www.ebi.ac.uk/interpro/entry/IPR007280 KEGG_Gene ecj:JW1167 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1167 KEGG_Gene eco:b1178 http://www.genome.jp/dbget-bin/www_bget?eco:b1178 OMA YNINIQI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YNINIQI PDB 4DXZ http://www.ebi.ac.uk/pdbe-srv/view/entry/4DXZ PDB 4DY3 http://www.ebi.ac.uk/pdbe-srv/view/entry/4DY3 PDB 4G9S http://www.ebi.ac.uk/pdbe-srv/view/entry/4G9S PDBsum 4DXZ http://www.ebi.ac.uk/pdbsum/4DXZ PDBsum 4DY3 http://www.ebi.ac.uk/pdbsum/4DY3 PDBsum 4G9S http://www.ebi.ac.uk/pdbsum/4G9S PSORT swissprot:PLIG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PLIG_ECOLI PSORT-B swissprot:PLIG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PLIG_ECOLI PSORT2 swissprot:PLIG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PLIG_ECOLI Pfam PF04151 http://pfam.xfam.org/family/PF04151 Phobius swissprot:PLIG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PLIG_ECOLI ProteinModelPortal P76002 http://www.proteinmodelportal.org/query/uniprot/P76002 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20734102 http://www.ncbi.nlm.nih.gov/pubmed/20734102 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415696 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415696 RefSeq WP_000695215 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000695215 SMR P76002 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76002 STRING 511145.b1178 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1178&targetmode=cogs SWISS-2DPAGE P76002 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P76002 UniProtKB PLIG_ECOLI http://www.uniprot.org/uniprot/PLIG_ECOLI UniProtKB-AC P76002 http://www.uniprot.org/uniprot/P76002 charge swissprot:PLIG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PLIG_ECOLI eggNOG ENOG41066UD http://eggnogapi.embl.de/nog_data/html/tree/ENOG41066UD eggNOG ENOG41129QS http://eggnogapi.embl.de/nog_data/html/tree/ENOG41129QS epestfind swissprot:PLIG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PLIG_ECOLI garnier swissprot:PLIG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PLIG_ECOLI helixturnhelix swissprot:PLIG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PLIG_ECOLI hmoment swissprot:PLIG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PLIG_ECOLI iep swissprot:PLIG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PLIG_ECOLI inforesidue swissprot:PLIG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PLIG_ECOLI octanol swissprot:PLIG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PLIG_ECOLI pepcoil swissprot:PLIG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PLIG_ECOLI pepdigest swissprot:PLIG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PLIG_ECOLI pepinfo swissprot:PLIG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PLIG_ECOLI pepnet swissprot:PLIG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PLIG_ECOLI pepstats swissprot:PLIG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PLIG_ECOLI pepwheel swissprot:PLIG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PLIG_ECOLI pepwindow swissprot:PLIG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PLIG_ECOLI sigcleave swissprot:PLIG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PLIG_ECOLI ## Database ID URL or Descriptions # BioGrid 4261700 19 # EcoGene EG13100 yqeI # GO_component GO:0005622 intracellular; IEA:GOC. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0000160 phosphorelay signal transduction system; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_component GO:0005622 intracellular # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # IntAct Q46942 3 # InterPro IPR001867 OmpR/PhoB-type_DNA-bd # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR016032 Sig_transdc_resp-reg_C-effctor # Organism YQEI_ECOLI Escherichia coli (strain K12) # PATRIC 32121112 VBIEscCol129921_2945 # PIR H65067 H65067 # PROSITE PS51755 OMPR_PHOB # Pfam PF00486 Trans_reg_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQEI_ECOLI Uncharacterized protein YqeI # RefSeq NP_417324 NC_000913.3 # RefSeq WP_001300710 NZ_LN832404.1 # SIMILARITY Contains 1 OmpR/PhoB-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU01091}. # SIMILARITY To V.cholerae cholera toxin transcriptional activator (ToxR). {ECO 0000305}. # SMART SM00862 Trans_reg_C # SUPFAM SSF46894 SSF46894 # eggNOG COG3710 LUCA # eggNOG ENOG4108TC1 Bacteria BLAST swissprot:YQEI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQEI_ECOLI BioCyc ECOL316407:JW2815-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2815-MONOMER BioCyc EcoCyc:G7467-MONOMER http://biocyc.org/getid?id=EcoCyc:G7467-MONOMER DIP DIP-12856N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12856N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 EchoBASE EB2903 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2903 EcoGene EG13100 http://www.ecogene.org/geneInfo.php?eg_id=EG13100 EnsemblBacteria AAC75886 http://www.ensemblgenomes.org/id/AAC75886 EnsemblBacteria AAC75886 http://www.ensemblgenomes.org/id/AAC75886 EnsemblBacteria BAE76916 http://www.ensemblgenomes.org/id/BAE76916 EnsemblBacteria BAE76916 http://www.ensemblgenomes.org/id/BAE76916 EnsemblBacteria BAE76916 http://www.ensemblgenomes.org/id/BAE76916 EnsemblBacteria b2847 http://www.ensemblgenomes.org/id/b2847 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 947327 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947327 HOGENOM HOG000294403 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000294403&db=HOGENOM6 IntAct Q46942 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46942* InterPro IPR001867 http://www.ebi.ac.uk/interpro/entry/IPR001867 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR016032 http://www.ebi.ac.uk/interpro/entry/IPR016032 KEGG_Gene ecj:JW2815 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2815 KEGG_Gene eco:b2847 http://www.genome.jp/dbget-bin/www_bget?eco:b2847 MINT MINT-1271068 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1271068 OMA TIRANCL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TIRANCL PROSITE PS51755 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51755 PSORT swissprot:YQEI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQEI_ECOLI PSORT-B swissprot:YQEI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQEI_ECOLI PSORT2 swissprot:YQEI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQEI_ECOLI Pfam PF00486 http://pfam.xfam.org/family/PF00486 Phobius swissprot:YQEI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQEI_ECOLI ProteinModelPortal Q46942 http://www.proteinmodelportal.org/query/uniprot/Q46942 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417324 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417324 RefSeq WP_001300710 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300710 SMART SM00862 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00862 SMR Q46942 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46942 STRING 511145.b2847 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2847&targetmode=cogs SUPFAM SSF46894 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46894 UniProtKB YQEI_ECOLI http://www.uniprot.org/uniprot/YQEI_ECOLI UniProtKB-AC Q46942 http://www.uniprot.org/uniprot/Q46942 charge swissprot:YQEI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQEI_ECOLI eggNOG COG3710 http://eggnogapi.embl.de/nog_data/html/tree/COG3710 eggNOG ENOG4108TC1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108TC1 epestfind swissprot:YQEI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQEI_ECOLI garnier swissprot:YQEI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQEI_ECOLI helixturnhelix swissprot:YQEI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQEI_ECOLI hmoment swissprot:YQEI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQEI_ECOLI iep swissprot:YQEI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQEI_ECOLI inforesidue swissprot:YQEI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQEI_ECOLI octanol swissprot:YQEI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQEI_ECOLI pepcoil swissprot:YQEI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQEI_ECOLI pepdigest swissprot:YQEI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQEI_ECOLI pepinfo swissprot:YQEI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQEI_ECOLI pepnet swissprot:YQEI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQEI_ECOLI pepstats swissprot:YQEI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQEI_ECOLI pepwheel swissprot:YQEI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQEI_ECOLI pepwindow swissprot:YQEI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQEI_ECOLI sigcleave swissprot:YQEI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQEI_ECOLI ## Database ID URL or Descriptions # AltName MCP2_ECOLI Aspartate chemoreceptor protein # BioGrid 4260381 311 # CDD cd00181 Tar_Tsr_LBD # CDD cd06225 HAMP # EcoGene EG10988 tar # FUNCTION MCP2_ECOLI Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. Attractants increase the level of methylation while repellents decrease the level of methylation, the methyl groups are added by the methyltransferase CheR and removed by the methylesterase CheB. # FUNCTION MCP2_ECOLI Receptor for the attractant L-aspartate and related amino and dicarboxylic acids. Tar also mediates taxis to the attractant maltose via an interaction with the periplasmic maltose binding protein. Tar mediates taxis away from the repellents cobalt and nickel. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_function GO:0004871 signal transducer activity; IMP:EcoCyc. # GO_function GO:0004888 transmembrane signaling receptor activity; IMP:EcoCyc. # GO_function GO:0043424 protein histidine kinase binding; IDA:EcoCyc. # GO_process GO:0006935 chemotaxis; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0019899 enzyme binding # GOslim_process GO:0040011 locomotion # Gene3D 1.20.120.30 -; 1. # INTERACTION MCP2_ECOLI P0A964 cheW; NbExp=3; IntAct=EBI-1125130, EBI-1125947; # IntAct P07017 7 # InterPro IPR003122 Chemotax_Me-accpt_rcpt_lig-bd # InterPro IPR003660 HAMP_dom # InterPro IPR004089 MCPsignal_dom # InterPro IPR004090 Chemotax_Me-accpt_rcpt # InterPro IPR004091 Chemotax_Me-accpt_rcpt_Me-site # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Pathway ko02020 Two-component system # KEGG_Pathway ko02030 Bacterial chemotaxis # Organism MCP2_ECOLI Escherichia coli (strain K12) # PATRIC 32119099 VBIEscCol129921_1967 # PDB 2ASR X-ray; 2.30 A; A=38-179 # PDB 2L9G NMR; -; A=214-232 # PDB 4Z9H X-ray; 1.45 A; A/B=26-193 # PDB 4Z9I X-ray; 1.57 A; A/B=26-193 # PDB 4Z9J X-ray; 1.78 A; A/B=26-193 # PIR F64951 QRECM4 # PRINTS PR00260 CHEMTRNSDUCR # PROSITE PS00538 CHEMOTAXIS_TRANSDUC_1 # PROSITE PS50111 CHEMOTAXIS_TRANSDUC_2 # PROSITE PS50885 HAMP # Pfam PF00015 MCPsignal # Pfam PF00672 HAMP # Pfam PF02203 TarH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MCP2_ECOLI Methyl-accepting chemotaxis protein II # RefSeq NP_416400 NC_000913.3 # RefSeq WP_001297437 NZ_LN832404.1 # SIMILARITY Contains 1 HAMP domain. {ECO:0000255|PROSITE- ProRule PRU00102}. # SIMILARITY Contains 1 methyl-accepting transducer domain. {ECO:0000255|PROSITE-ProRule PRU00284}. # SMART SM00283 MA # SMART SM00304 HAMP # SMART SM00319 TarH # SUBCELLULAR LOCATION MCP2_ECOLI Cell inner membrane {ECO 0000269|PubMed 22380631}; Multi-pass membrane protein {ECO 0000269|PubMed 22380631}. Note=Found predominantly at cell poles. # SUPFAM SSF47170 SSF47170 # eggNOG COG0840 LUCA # eggNOG ENOG4105C8Q Bacteria BLAST swissprot:MCP2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MCP2_ECOLI BioCyc ECOL316407:JW1875-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1875-MONOMER BioCyc EcoCyc:TAR-MONOMER http://biocyc.org/getid?id=EcoCyc:TAR-MONOMER COG COG0840 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0840 DIP DIP-10956N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10956N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0092-8674(83)90442-7 http://dx.doi.org/10.1016/0092-8674(83)90442-7 DOI 10.1016/S0014-5793(97)01027-2 http://dx.doi.org/10.1016/S0014-5793(97)01027-2 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1107/S0907444994010498 http://dx.doi.org/10.1107/S0907444994010498 DOI 10.1111/j.1365-2958.2012.08021.x http://dx.doi.org/10.1111/j.1365-2958.2012.08021.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DisProt DP00294 http://www.disprot.org/protein.php?id=DP00294 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01705 http://www.ebi.ac.uk/ena/data/view/J01705 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0981 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0981 EcoGene EG10988 http://www.ecogene.org/geneInfo.php?eg_id=EG10988 EnsemblBacteria AAC74956 http://www.ensemblgenomes.org/id/AAC74956 EnsemblBacteria AAC74956 http://www.ensemblgenomes.org/id/AAC74956 EnsemblBacteria BAA15702 http://www.ensemblgenomes.org/id/BAA15702 EnsemblBacteria BAA15702 http://www.ensemblgenomes.org/id/BAA15702 EnsemblBacteria BAA15702 http://www.ensemblgenomes.org/id/BAA15702 EnsemblBacteria b1886 http://www.ensemblgenomes.org/id/b1886 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GO_function GO:0004888 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004888 GO_function GO:0043424 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043424 GO_process GO:0006935 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006935 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0019899 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899 GOslim_process GO:0040011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011 Gene3D 1.20.120.30 http://www.cathdb.info/version/latest/superfamily/1.20.120.30 GeneID 946399 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946399 HOGENOM HOG000148074 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000148074&db=HOGENOM6 InParanoid P07017 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P07017 IntAct P07017 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P07017* InterPro IPR003122 http://www.ebi.ac.uk/interpro/entry/IPR003122 InterPro IPR003660 http://www.ebi.ac.uk/interpro/entry/IPR003660 InterPro IPR004089 http://www.ebi.ac.uk/interpro/entry/IPR004089 InterPro IPR004090 http://www.ebi.ac.uk/interpro/entry/IPR004090 InterPro IPR004091 http://www.ebi.ac.uk/interpro/entry/IPR004091 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW1875 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1875 KEGG_Gene eco:b1886 http://www.genome.jp/dbget-bin/www_bget?eco:b1886 KEGG_Orthology KO:K05875 http://www.genome.jp/dbget-bin/www_bget?KO:K05875 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 KEGG_Pathway ko02030 http://www.genome.jp/kegg-bin/show_pathway?ko02030 OMA GDDANWE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GDDANWE PDB 2ASR http://www.ebi.ac.uk/pdbe-srv/view/entry/2ASR PDB 2L9G http://www.ebi.ac.uk/pdbe-srv/view/entry/2L9G PDB 4Z9H http://www.ebi.ac.uk/pdbe-srv/view/entry/4Z9H PDB 4Z9I http://www.ebi.ac.uk/pdbe-srv/view/entry/4Z9I PDB 4Z9J http://www.ebi.ac.uk/pdbe-srv/view/entry/4Z9J PDBsum 2ASR http://www.ebi.ac.uk/pdbsum/2ASR PDBsum 2L9G http://www.ebi.ac.uk/pdbsum/2L9G PDBsum 4Z9H http://www.ebi.ac.uk/pdbsum/4Z9H PDBsum 4Z9I http://www.ebi.ac.uk/pdbsum/4Z9I PDBsum 4Z9J http://www.ebi.ac.uk/pdbsum/4Z9J PRINTS PR00260 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00260 PROSITE PS00538 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00538 PROSITE PS50111 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50111 PROSITE PS50885 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50885 PSORT swissprot:MCP2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MCP2_ECOLI PSORT-B swissprot:MCP2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MCP2_ECOLI PSORT2 swissprot:MCP2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MCP2_ECOLI Pfam PF00015 http://pfam.xfam.org/family/PF00015 Pfam PF00672 http://pfam.xfam.org/family/PF00672 Pfam PF02203 http://pfam.xfam.org/family/PF02203 Phobius swissprot:MCP2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MCP2_ECOLI PhylomeDB P07017 http://phylomedb.org/?seqid=P07017 ProteinModelPortal P07017 http://www.proteinmodelportal.org/query/uniprot/P07017 PubMed 15299315 http://www.ncbi.nlm.nih.gov/pubmed/15299315 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22380631 http://www.ncbi.nlm.nih.gov/pubmed/22380631 PubMed 6305515 http://www.ncbi.nlm.nih.gov/pubmed/6305515 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9315712 http://www.ncbi.nlm.nih.gov/pubmed/9315712 RefSeq NP_416400 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416400 RefSeq WP_001297437 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001297437 SMART SM00283 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00283 SMART SM00304 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00304 SMART SM00319 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00319 SMR P07017 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P07017 STRING 511145.b1886 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1886&targetmode=cogs STRING COG0840 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0840&targetmode=cogs SUPFAM SSF47170 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47170 UniProtKB MCP2_ECOLI http://www.uniprot.org/uniprot/MCP2_ECOLI UniProtKB-AC P07017 http://www.uniprot.org/uniprot/P07017 charge swissprot:MCP2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MCP2_ECOLI eggNOG COG0840 http://eggnogapi.embl.de/nog_data/html/tree/COG0840 eggNOG ENOG4105C8Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C8Q epestfind swissprot:MCP2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MCP2_ECOLI garnier swissprot:MCP2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MCP2_ECOLI helixturnhelix swissprot:MCP2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MCP2_ECOLI hmoment swissprot:MCP2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MCP2_ECOLI iep swissprot:MCP2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MCP2_ECOLI inforesidue swissprot:MCP2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MCP2_ECOLI octanol swissprot:MCP2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MCP2_ECOLI pepcoil swissprot:MCP2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MCP2_ECOLI pepdigest swissprot:MCP2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MCP2_ECOLI pepinfo swissprot:MCP2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MCP2_ECOLI pepnet swissprot:MCP2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MCP2_ECOLI pepstats swissprot:MCP2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MCP2_ECOLI pepwheel swissprot:MCP2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MCP2_ECOLI pepwindow swissprot:MCP2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MCP2_ECOLI sigcleave swissprot:MCP2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MCP2_ECOLI ## Database ID URL or Descriptions # AltName CMP-2-keto-3-deoxyoctulosonic acid synthase {ECO:0000255|HAMAP-Rule MF_00057} # BioGrid 4260010 206 # CATALYTIC ACTIVITY CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate. {ECO:0000255|HAMAP-Rule MF_00057}. # CDD cd02517 CMP-KDO-Synthetase # COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI 18420; # EcoGene EG10519 kdsB # FUNCTION KDSB_ECOLI Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. {ECO 0000255|HAMAP-Rule MF_00057}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0008690 3-deoxy-manno-octulosonate cytidylyltransferase activity; IDA:EcoCyc. # GO_process GO:0019294 keto-3-deoxy-D-manno-octulosonic acid biosynthetic process; IDA:EcoCyc. # GO_process GO:0033468 CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.90.550.10 -; 1. # HAMAP MF_00057 KdsB # INTERACTION KDSB_ECOLI P67430 nemR; NbExp=2; IntAct=EBI-544810, EBI-544803; P0ACU2 rutR; NbExp=2; IntAct=EBI-544810, EBI-1121539; # IntAct P04951 19 # InterPro IPR003329 Cytidylyl_trans # InterPro IPR004528 KdsB # InterPro IPR029044 Nucleotide-diphossugar_trans # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # KEGG_Pathway ko00540 Lipopolysaccharide biosynthesis # Organism KDSB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21485:SF4 PTHR21485:SF4 # PATHWAY Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. {ECO:0000255|HAMAP-Rule MF_00057}. # PATHWAY Nucleotide-sugar biosynthesis; CMP-3-deoxy-D-manno- octulosonate biosynthesis; CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP: step 1/1. {ECO 0000255|HAMAP-Rule:MF_00057}. # PATRIC 32117049 VBIEscCol129921_0949 # PDB 1VH1 X-ray; 2.60 A; A/B/C/D=2-248 # PDB 3K8D X-ray; 1.90 A; A/B/C/D=1-248 # PDB 3K8E X-ray; 2.51 A; A/B/C/D=1-248 # PIR A26322 A26322 # Pfam PF02348 CTP_transf_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 3-deoxy-manno-octulosonate cytidylyltransferase {ECO:0000255|HAMAP-Rule MF_00057} # RefSeq NP_415438 NC_000913.3 # RefSeq WP_000011603 NZ_LN832404.1 # SIMILARITY Belongs to the KdsB family. {ECO:0000255|HAMAP- Rule MF_00057}. # SUBCELLULAR LOCATION KDSB_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00057}. # SUPFAM SSF53448 SSF53448 # TIGRFAMs TIGR00466 kdsB # UniPathway UPA00358 UER00476 # eggNOG COG1212 LUCA # eggNOG ENOG4105CET Bacteria BLAST swissprot:KDSB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:KDSB_ECOLI BioCyc ECOL316407:JW0901-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0901-MONOMER BioCyc EcoCyc:CPM-KDOSYNTH-MONOMER http://biocyc.org/getid?id=EcoCyc:CPM-KDOSYNTH-MONOMER BioCyc MetaCyc:CPM-KDOSYNTH-MONOMER http://biocyc.org/getid?id=MetaCyc:CPM-KDOSYNTH-MONOMER COG COG1212 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1212 DIP DIP-10066N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10066N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.7.38 {ECO:0000255|HAMAP-Rule:MF_00057} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.38 {ECO:0000255|HAMAP-Rule:MF_00057} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J02614 http://www.ebi.ac.uk/ena/data/view/J02614 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.7.38 {ECO:0000255|HAMAP-Rule:MF_00057} http://enzyme.expasy.org/EC/2.7.7.38 {ECO:0000255|HAMAP-Rule:MF_00057} EchoBASE EB0514 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0514 EcoGene EG10519 http://www.ecogene.org/geneInfo.php?eg_id=EG10519 EnsemblBacteria AAC74004 http://www.ensemblgenomes.org/id/AAC74004 EnsemblBacteria AAC74004 http://www.ensemblgenomes.org/id/AAC74004 EnsemblBacteria BAA35664 http://www.ensemblgenomes.org/id/BAA35664 EnsemblBacteria BAA35664 http://www.ensemblgenomes.org/id/BAA35664 EnsemblBacteria BAA35664 http://www.ensemblgenomes.org/id/BAA35664 EnsemblBacteria b0918 http://www.ensemblgenomes.org/id/b0918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0008690 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008690 GO_process GO:0019294 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019294 GO_process GO:0033468 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033468 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.90.550.10 http://www.cathdb.info/version/latest/superfamily/3.90.550.10 GeneID 945539 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945539 HAMAP MF_00057 http://hamap.expasy.org/unirule/MF_00057 HOGENOM HOG000007602 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000007602&db=HOGENOM6 InParanoid P04951 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P04951 IntAct P04951 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P04951* IntEnz 2.7.7.38 {ECO:0000255|HAMAP-Rule:MF_00057} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.38 {ECO:0000255|HAMAP-Rule:MF_00057} InterPro IPR003329 http://www.ebi.ac.uk/interpro/entry/IPR003329 InterPro IPR004528 http://www.ebi.ac.uk/interpro/entry/IPR004528 InterPro IPR029044 http://www.ebi.ac.uk/interpro/entry/IPR029044 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Gene ecj:JW0901 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0901 KEGG_Gene eco:b0918 http://www.genome.jp/dbget-bin/www_bget?eco:b0918 KEGG_Orthology KO:K00979 http://www.genome.jp/dbget-bin/www_bget?KO:K00979 KEGG_Pathway ko00540 http://www.genome.jp/kegg-bin/show_pathway?ko00540 KEGG_Reaction rn:R03351 http://www.genome.jp/dbget-bin/www_bget?rn:R03351 MINT MINT-1224838 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1224838 OMA NSGTERC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NSGTERC PANTHER PTHR21485:SF4 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21485:SF4 PDB 1VH1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1VH1 PDB 3K8D http://www.ebi.ac.uk/pdbe-srv/view/entry/3K8D PDB 3K8E http://www.ebi.ac.uk/pdbe-srv/view/entry/3K8E PDBsum 1VH1 http://www.ebi.ac.uk/pdbsum/1VH1 PDBsum 3K8D http://www.ebi.ac.uk/pdbsum/3K8D PDBsum 3K8E http://www.ebi.ac.uk/pdbsum/3K8E PSORT swissprot:KDSB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:KDSB_ECOLI PSORT-B swissprot:KDSB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:KDSB_ECOLI PSORT2 swissprot:KDSB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:KDSB_ECOLI Pfam PF02348 http://pfam.xfam.org/family/PF02348 Phobius swissprot:KDSB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:KDSB_ECOLI PhylomeDB P04951 http://phylomedb.org/?seqid=P04951 ProteinModelPortal P04951 http://www.proteinmodelportal.org/query/uniprot/P04951 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3023327 http://www.ncbi.nlm.nih.gov/pubmed/3023327 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_415438 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415438 RefSeq WP_000011603 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000011603 SMR P04951 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P04951 STRING 511145.b0918 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0918&targetmode=cogs STRING COG1212 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1212&targetmode=cogs SUPFAM SSF53448 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53448 SWISS-2DPAGE P04951 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P04951 TIGRFAMs TIGR00466 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00466 UniProtKB KDSB_ECOLI http://www.uniprot.org/uniprot/KDSB_ECOLI UniProtKB-AC P04951 http://www.uniprot.org/uniprot/P04951 charge swissprot:KDSB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:KDSB_ECOLI eggNOG COG1212 http://eggnogapi.embl.de/nog_data/html/tree/COG1212 eggNOG ENOG4105CET http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CET epestfind swissprot:KDSB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:KDSB_ECOLI garnier swissprot:KDSB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:KDSB_ECOLI helixturnhelix swissprot:KDSB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:KDSB_ECOLI hmoment swissprot:KDSB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:KDSB_ECOLI iep swissprot:KDSB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:KDSB_ECOLI inforesidue swissprot:KDSB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:KDSB_ECOLI octanol swissprot:KDSB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:KDSB_ECOLI pepcoil swissprot:KDSB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:KDSB_ECOLI pepdigest swissprot:KDSB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:KDSB_ECOLI pepinfo swissprot:KDSB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:KDSB_ECOLI pepnet swissprot:KDSB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:KDSB_ECOLI pepstats swissprot:KDSB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:KDSB_ECOLI pepwheel swissprot:KDSB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:KDSB_ECOLI pepwindow swissprot:KDSB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:KDSB_ECOLI sigcleave swissprot:KDSB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:KDSB_ECOLI ## Database ID URL or Descriptions # AltName NAD(P)H-dependent glycerol-3-phosphate dehydrogenase {ECO:0000255|HAMAP-Rule MF_00394} # BioGrid 4261595 125 # CATALYTIC ACTIVITY sn-glycerol 3-phosphate + NAD(P)(+) = glycerone phosphate + NAD(P)H. {ECO:0000255|HAMAP-Rule MF_00394}. # EcoGene EG20091 gpsA # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0009331 glycerol-3-phosphate dehydrogenase complex; IEA:InterPro. # GO_function GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity; IEA:UniProtKB-EC. # GO_function GO:0036439 glycerol-3-phosphate dehydrogenase [NADP+] activity; IEA:UniProtKB-EC. # GO_function GO:0047952 glycerol-3-phosphate dehydrogenase [NAD(P)+] activity; IDA:EcoCyc. # GO_function GO:0051287 NAD binding; IEA:InterPro. # GO_process GO:0005975 carbohydrate metabolic process; IEA:InterPro. # GO_process GO:0046167 glycerol-3-phosphate biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0046168 glycerol-3-phosphate catabolic process; IEA:InterPro. # GO_process GO:0046474 glycerophospholipid biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 1.10.1040.10 -; 1. # Gene3D 3.40.50.720 -; 1. # HAMAP MF_00394 NAD_Glyc3P_dehydrog # IntAct P0A6S7 6 # InterPro IPR006109 G3P_DH_NAD-dep_C # InterPro IPR006168 G3P_DH_NAD-dep # InterPro IPR008927 6-PGluconate_DH_C-like # InterPro IPR011128 G3P_DH_NAD-dep_N # InterPro IPR013328 6PGD_dom_2 # InterPro IPR016040 NAD(P)-bd_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00564 Glycerophospholipid metabolism # Organism GPDA_ECOLI Escherichia coli (strain K12) # PATHWAY Membrane lipid metabolism; glycerophospholipid metabolism. {ECO:0000255|HAMAP-Rule MF_00394}. # PATRIC 32122701 VBIEscCol129921_3727 # PIR S47829 S47829 # PIRSF PIRSF000114 Glycerol-3-P_dh # PRINTS PR00077 GPDHDRGNASE # PROSITE PS00957 NAD_G3PDH # Pfam PF01210 NAD_Gly3P_dh_N # Pfam PF07479 NAD_Gly3P_dh_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Glycerol-3-phosphate dehydrogenase [NAD(P)+] {ECO:0000255|HAMAP-Rule MF_00394} # RefSeq NP_418065 NC_000913.3 # RefSeq WP_001076194 NZ_LN832404.1 # SIMILARITY Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. {ECO:0000255|HAMAP-Rule MF_00394}. # SUBCELLULAR LOCATION GPDA_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00394}. # SUPFAM SSF48179 SSF48179 # SUPFAM SSF51735 SSF51735 # eggNOG COG0240 LUCA # eggNOG ENOG4105CSF Bacteria BLAST swissprot:GPDA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GPDA_ECOLI BioCyc ECOL316407:JW3583-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3583-MONOMER BioCyc EcoCyc:GLYC3PDEHYDROGBIOSYN-MONOMER http://biocyc.org/getid?id=EcoCyc:GLYC3PDEHYDROGBIOSYN-MONOMER BioCyc MetaCyc:GLYC3PDEHYDROGBIOSYN-MONOMER http://biocyc.org/getid?id=MetaCyc:GLYC3PDEHYDROGBIOSYN-MONOMER COG COG0240 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0240 DIP DIP-48003N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48003N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.94 {ECO:0000255|HAMAP-Rule:MF_00394} http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.94 {ECO:0000255|HAMAP-Rule:MF_00394} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.1.1.94 {ECO:0000255|HAMAP-Rule:MF_00394} http://enzyme.expasy.org/EC/1.1.1.94 {ECO:0000255|HAMAP-Rule:MF_00394} EchoBASE EB4142 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4142 EcoGene EG20091 http://www.ecogene.org/geneInfo.php?eg_id=EG20091 EnsemblBacteria AAC76632 http://www.ensemblgenomes.org/id/AAC76632 EnsemblBacteria AAC76632 http://www.ensemblgenomes.org/id/AAC76632 EnsemblBacteria BAE77684 http://www.ensemblgenomes.org/id/BAE77684 EnsemblBacteria BAE77684 http://www.ensemblgenomes.org/id/BAE77684 EnsemblBacteria BAE77684 http://www.ensemblgenomes.org/id/BAE77684 EnsemblBacteria b3608 http://www.ensemblgenomes.org/id/b3608 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0009331 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009331 GO_function GO:0004367 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004367 GO_function GO:0036439 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036439 GO_function GO:0047952 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047952 GO_function GO:0051287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051287 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GO_process GO:0046167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046167 GO_process GO:0046168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046168 GO_process GO:0046474 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046474 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 1.10.1040.10 http://www.cathdb.info/version/latest/superfamily/1.10.1040.10 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 948125 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948125 HAMAP MF_00394 http://hamap.expasy.org/unirule/MF_00394 HOGENOM HOG000246854 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000246854&db=HOGENOM6 InParanoid P0A6S7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6S7 IntAct P0A6S7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6S7* IntEnz 1.1.1.94 {ECO:0000255|HAMAP-Rule:MF_00394} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.94 {ECO:0000255|HAMAP-Rule:MF_00394} InterPro IPR006109 http://www.ebi.ac.uk/interpro/entry/IPR006109 InterPro IPR006168 http://www.ebi.ac.uk/interpro/entry/IPR006168 InterPro IPR008927 http://www.ebi.ac.uk/interpro/entry/IPR008927 InterPro IPR011128 http://www.ebi.ac.uk/interpro/entry/IPR011128 InterPro IPR013328 http://www.ebi.ac.uk/interpro/entry/IPR013328 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3583 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3583 KEGG_Gene eco:b3608 http://www.genome.jp/dbget-bin/www_bget?eco:b3608 KEGG_Orthology KO:K00057 http://www.genome.jp/dbget-bin/www_bget?KO:K00057 KEGG_Pathway ko00564 http://www.genome.jp/kegg-bin/show_pathway?ko00564 KEGG_Reaction rn:R00842 http://www.genome.jp/dbget-bin/www_bget?rn:R00842 KEGG_Reaction rn:R00844 http://www.genome.jp/dbget-bin/www_bget?rn:R00844 OMA SAQMEMS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SAQMEMS PRINTS PR00077 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00077 PROSITE PS00957 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00957 PSORT swissprot:GPDA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GPDA_ECOLI PSORT-B swissprot:GPDA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GPDA_ECOLI PSORT2 swissprot:GPDA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GPDA_ECOLI Pfam PF01210 http://pfam.xfam.org/family/PF01210 Pfam PF07479 http://pfam.xfam.org/family/PF07479 Phobius swissprot:GPDA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GPDA_ECOLI PhylomeDB P0A6S7 http://phylomedb.org/?seqid=P0A6S7 ProteinModelPortal P0A6S7 http://www.proteinmodelportal.org/query/uniprot/P0A6S7 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418065 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418065 RefSeq WP_001076194 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001076194 SMR P0A6S7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6S7 STRING 511145.b3608 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3608&targetmode=cogs STRING COG0240 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0240&targetmode=cogs SUPFAM SSF48179 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48179 SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB GPDA_ECOLI http://www.uniprot.org/uniprot/GPDA_ECOLI UniProtKB-AC P0A6S7 http://www.uniprot.org/uniprot/P0A6S7 charge swissprot:GPDA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GPDA_ECOLI eggNOG COG0240 http://eggnogapi.embl.de/nog_data/html/tree/COG0240 eggNOG ENOG4105CSF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CSF epestfind swissprot:GPDA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GPDA_ECOLI garnier swissprot:GPDA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GPDA_ECOLI helixturnhelix swissprot:GPDA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GPDA_ECOLI hmoment swissprot:GPDA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GPDA_ECOLI iep swissprot:GPDA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GPDA_ECOLI inforesidue swissprot:GPDA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GPDA_ECOLI octanol swissprot:GPDA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GPDA_ECOLI pepcoil swissprot:GPDA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GPDA_ECOLI pepdigest swissprot:GPDA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GPDA_ECOLI pepinfo swissprot:GPDA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GPDA_ECOLI pepnet swissprot:GPDA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GPDA_ECOLI pepstats swissprot:GPDA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GPDA_ECOLI pepwheel swissprot:GPDA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GPDA_ECOLI pepwindow swissprot:GPDA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GPDA_ECOLI sigcleave swissprot:GPDA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GPDA_ECOLI ## Database ID URL or Descriptions # BioGrid 4263363 6 # EcoGene EG11468 rhtC # FUNCTION RHTC_ECOLI Conducts the efflux of threonine. {ECO 0000269|PubMed 10386596}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015171 amino acid transmembrane transporter activity; IBA:GO_Central. # GO_process GO:0006865 amino acid transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR001123 LysE-type # InterPro IPR004778 Homoserine/Threonine_efflux # KEGG_Brite ko02000 Transporters # Organism RHTC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30086 PTHR30086 # PATRIC 32123147 VBIEscCol129921_3939 # PIRSF PIRSF006324 LeuE # Pfam PF01810 LysE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RHTC_ECOLI Threonine efflux protein # RefSeq WP_000928824 NZ_LN832404.1 # RefSeq YP_026264 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA67619.1; Type=Frameshift; Positions=80, 118; Evidence={ECO:0000305}; Sequence=M30198; Type=Frameshift; Positions=47, 73; Evidence={ECO 0000305}; # SIMILARITY Belongs to the rht family. {ECO 0000305}. # SUBCELLULAR LOCATION RHTC_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # TCDB 2.A.76.1 the resistance to homoserine/threonine (rhtb) family # TIGRFAMs TIGR00949 2A76 # eggNOG COG1280 LUCA # eggNOG ENOG4105CCF Bacteria BLAST swissprot:RHTC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RHTC_ECOLI BioCyc ECOL316407:JW5586-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5586-MONOMER BioCyc EcoCyc:RHTC-MONOMER http://biocyc.org/getid?id=EcoCyc:RHTC-MONOMER BioCyc MetaCyc:RHTC-MONOMER http://biocyc.org/getid?id=MetaCyc:RHTC-MONOMER COG COG1280 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1280 DOI 10.1007/BF00430442 http://dx.doi.org/10.1007/BF00430442 DOI 10.1016/S0014-5793(99)00625-0 http://dx.doi.org/10.1016/S0014-5793(99)00625-0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M30198 http://www.ebi.ac.uk/ena/data/view/M30198 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1436 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1436 EcoGene EG11468 http://www.ecogene.org/geneInfo.php?eg_id=EG11468 EnsemblBacteria AAT48222 http://www.ensemblgenomes.org/id/AAT48222 EnsemblBacteria AAT48222 http://www.ensemblgenomes.org/id/AAT48222 EnsemblBacteria BAE77478 http://www.ensemblgenomes.org/id/BAE77478 EnsemblBacteria BAE77478 http://www.ensemblgenomes.org/id/BAE77478 EnsemblBacteria BAE77478 http://www.ensemblgenomes.org/id/BAE77478 EnsemblBacteria b3823 http://www.ensemblgenomes.org/id/b3823 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015171 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171 GO_process GO:0006865 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948317 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948317 HOGENOM HOG000122945 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122945&db=HOGENOM6 InParanoid P0AG38 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AG38 InterPro IPR001123 http://www.ebi.ac.uk/interpro/entry/IPR001123 InterPro IPR004778 http://www.ebi.ac.uk/interpro/entry/IPR004778 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5586 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5586 KEGG_Gene eco:b3823 http://www.genome.jp/dbget-bin/www_bget?eco:b3823 KEGG_Orthology KO:K05835 http://www.genome.jp/dbget-bin/www_bget?KO:K05835 OMA IVMKNTI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IVMKNTI PANTHER PTHR30086 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30086 PSORT swissprot:RHTC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RHTC_ECOLI PSORT-B swissprot:RHTC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RHTC_ECOLI PSORT2 swissprot:RHTC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RHTC_ECOLI Pfam PF01810 http://pfam.xfam.org/family/PF01810 Phobius swissprot:RHTC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RHTC_ECOLI PhylomeDB P0AG38 http://phylomedb.org/?seqid=P0AG38 ProteinModelPortal P0AG38 http://www.proteinmodelportal.org/query/uniprot/P0AG38 PubMed 10386596 http://www.ncbi.nlm.nih.gov/pubmed/10386596 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3027506 http://www.ncbi.nlm.nih.gov/pubmed/3027506 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000928824 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000928824 RefSeq YP_026264 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026264 STRING 511145.b3823 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3823&targetmode=cogs STRING COG1280 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1280&targetmode=cogs TCDB 2.A.76.1 http://www.tcdb.org/search/result.php?tc=2.A.76.1 TIGRFAMs TIGR00949 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00949 UniProtKB RHTC_ECOLI http://www.uniprot.org/uniprot/RHTC_ECOLI UniProtKB-AC P0AG38 http://www.uniprot.org/uniprot/P0AG38 charge swissprot:RHTC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RHTC_ECOLI eggNOG COG1280 http://eggnogapi.embl.de/nog_data/html/tree/COG1280 eggNOG ENOG4105CCF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CCF epestfind swissprot:RHTC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RHTC_ECOLI garnier swissprot:RHTC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RHTC_ECOLI helixturnhelix swissprot:RHTC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RHTC_ECOLI hmoment swissprot:RHTC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RHTC_ECOLI iep swissprot:RHTC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RHTC_ECOLI inforesidue swissprot:RHTC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RHTC_ECOLI octanol swissprot:RHTC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RHTC_ECOLI pepcoil swissprot:RHTC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RHTC_ECOLI pepdigest swissprot:RHTC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RHTC_ECOLI pepinfo swissprot:RHTC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RHTC_ECOLI pepnet swissprot:RHTC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RHTC_ECOLI pepstats swissprot:RHTC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RHTC_ECOLI pepwheel swissprot:RHTC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RHTC_ECOLI pepwindow swissprot:RHTC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RHTC_ECOLI sigcleave swissprot:RHTC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RHTC_ECOLI ## Database ID URL or Descriptions # BioGrid 4262017 15 # EcoGene EG13203 yfjQ # IntAct P52132 2 # InterPro IPR026325 DUF932 # Organism YFJQ_ECOLI Escherichia coli (strain K12) # PATRIC 32120657 VBIEscCol129921_2727 # PIR T08645 T08645 # Pfam PF06067 DUF932 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFJQ_ECOLI UPF0380 protein YfjQ # RefSeq NP_417122 NC_000913.3 # RefSeq WP_000197391 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0380 family. {ECO 0000305}. # eggNOG ENOG4106H6R Bacteria # eggNOG ENOG410XPYV LUCA BLAST swissprot:YFJQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFJQ_ECOLI BioCyc ECOL316407:JW2614-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2614-MONOMER BioCyc EcoCyc:G7368-MONOMER http://biocyc.org/getid?id=EcoCyc:G7368-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36840 http://www.ebi.ac.uk/ena/data/view/U36840 EchoBASE EB2995 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2995 EcoGene EG13203 http://www.ecogene.org/geneInfo.php?eg_id=EG13203 EnsemblBacteria AAC75681 http://www.ensemblgenomes.org/id/AAC75681 EnsemblBacteria AAC75681 http://www.ensemblgenomes.org/id/AAC75681 EnsemblBacteria BAE76768 http://www.ensemblgenomes.org/id/BAE76768 EnsemblBacteria BAE76768 http://www.ensemblgenomes.org/id/BAE76768 EnsemblBacteria BAE76768 http://www.ensemblgenomes.org/id/BAE76768 EnsemblBacteria b2633 http://www.ensemblgenomes.org/id/b2633 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947127 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947127 HOGENOM HOG000222632 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000222632&db=HOGENOM6 IntAct P52132 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P52132* InterPro IPR026325 http://www.ebi.ac.uk/interpro/entry/IPR026325 KEGG_Gene ecj:JW2614 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2614 KEGG_Gene eco:b2633 http://www.genome.jp/dbget-bin/www_bget?eco:b2633 OMA HPLSDDQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HPLSDDQ PSORT swissprot:YFJQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFJQ_ECOLI PSORT-B swissprot:YFJQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFJQ_ECOLI PSORT2 swissprot:YFJQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFJQ_ECOLI Pfam PF06067 http://pfam.xfam.org/family/PF06067 Phobius swissprot:YFJQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFJQ_ECOLI PhylomeDB P52132 http://phylomedb.org/?seqid=P52132 ProteinModelPortal P52132 http://www.proteinmodelportal.org/query/uniprot/P52132 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417122 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417122 RefSeq WP_000197391 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000197391 STRING 511145.b2633 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2633&targetmode=cogs UniProtKB YFJQ_ECOLI http://www.uniprot.org/uniprot/YFJQ_ECOLI UniProtKB-AC P52132 http://www.uniprot.org/uniprot/P52132 charge swissprot:YFJQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFJQ_ECOLI eggNOG ENOG4106H6R http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106H6R eggNOG ENOG410XPYV http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPYV epestfind swissprot:YFJQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFJQ_ECOLI garnier swissprot:YFJQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFJQ_ECOLI helixturnhelix swissprot:YFJQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFJQ_ECOLI hmoment swissprot:YFJQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFJQ_ECOLI iep swissprot:YFJQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFJQ_ECOLI inforesidue swissprot:YFJQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFJQ_ECOLI octanol swissprot:YFJQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFJQ_ECOLI pepcoil swissprot:YFJQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFJQ_ECOLI pepdigest swissprot:YFJQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFJQ_ECOLI pepinfo swissprot:YFJQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFJQ_ECOLI pepnet swissprot:YFJQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFJQ_ECOLI pepstats swissprot:YFJQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFJQ_ECOLI pepwheel swissprot:YFJQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFJQ_ECOLI pepwindow swissprot:YFJQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFJQ_ECOLI sigcleave swissprot:YFJQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFJQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4263245 4 # EcoGene EG12533 yjgN # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR010295 DUF898 # Organism YJGN_ECOLI Escherichia coli (strain K12) # PATRIC 32124085 VBIEscCol129921_4387 # PIR D65238 D65238 # PIR S56482 S56482 # Pfam PF05987 DUF898 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJGN_ECOLI Inner membrane protein YjgN # RefSeq WP_000079634 NZ_LN832404.1 # RefSeq YP_026288 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA97154.1; Type=Frameshift; Positions=10, 16, 96, 199; Evidence={ECO 0000305}; # SUBCELLULAR LOCATION YJGN_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG COG4269 LUCA # eggNOG ENOG4108M3P Bacteria BLAST swissprot:YJGN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJGN_ECOLI BioCyc ECOL316407:JW5759-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5759-MONOMER BioCyc EcoCyc:G7887-MONOMER http://biocyc.org/getid?id=EcoCyc:G7887-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2423 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2423 EcoGene EG12533 http://www.ecogene.org/geneInfo.php?eg_id=EG12533 EnsemblBacteria AAT48246 http://www.ensemblgenomes.org/id/AAT48246 EnsemblBacteria AAT48246 http://www.ensemblgenomes.org/id/AAT48246 EnsemblBacteria BAE78254 http://www.ensemblgenomes.org/id/BAE78254 EnsemblBacteria BAE78254 http://www.ensemblgenomes.org/id/BAE78254 EnsemblBacteria BAE78254 http://www.ensemblgenomes.org/id/BAE78254 EnsemblBacteria b4257 http://www.ensemblgenomes.org/id/b4257 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 948784 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948784 HOGENOM HOG000127441 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000127441&db=HOGENOM6 InterPro IPR010295 http://www.ebi.ac.uk/interpro/entry/IPR010295 KEGG_Gene ecj:JW5759 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5759 KEGG_Gene eco:b4257 http://www.genome.jp/dbget-bin/www_bget?eco:b4257 OMA LRAWWVM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LRAWWVM PSORT swissprot:YJGN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJGN_ECOLI PSORT-B swissprot:YJGN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJGN_ECOLI PSORT2 swissprot:YJGN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJGN_ECOLI Pfam PF05987 http://pfam.xfam.org/family/PF05987 Phobius swissprot:YJGN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJGN_ECOLI ProteinModelPortal P39338 http://www.proteinmodelportal.org/query/uniprot/P39338 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000079634 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000079634 RefSeq YP_026288 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026288 STRING 511145.b4257 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4257&targetmode=cogs UniProtKB YJGN_ECOLI http://www.uniprot.org/uniprot/YJGN_ECOLI UniProtKB-AC P39338 http://www.uniprot.org/uniprot/P39338 charge swissprot:YJGN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJGN_ECOLI eggNOG COG4269 http://eggnogapi.embl.de/nog_data/html/tree/COG4269 eggNOG ENOG4108M3P http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108M3P epestfind swissprot:YJGN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJGN_ECOLI garnier swissprot:YJGN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJGN_ECOLI helixturnhelix swissprot:YJGN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJGN_ECOLI hmoment swissprot:YJGN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJGN_ECOLI iep swissprot:YJGN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJGN_ECOLI inforesidue swissprot:YJGN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJGN_ECOLI octanol swissprot:YJGN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJGN_ECOLI pepcoil swissprot:YJGN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJGN_ECOLI pepdigest swissprot:YJGN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJGN_ECOLI pepinfo swissprot:YJGN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJGN_ECOLI pepnet swissprot:YJGN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJGN_ECOLI pepstats swissprot:YJGN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJGN_ECOLI pepwheel swissprot:YJGN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJGN_ECOLI pepwindow swissprot:YJGN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJGN_ECOLI sigcleave swissprot:YJGN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJGN_ECOLI ## Database ID URL or Descriptions # BioGrid 4259280 236 # DISRUPTION PHENOTYPE Results in an earlier growth arrest and onset of cell lethality. {ECO:0000269|PubMed 16765569}. # DOMAIN LPTA_ECOLI The N-terminal domain interacts with LptC, at the inner membrane, and the C-terminal domain interacts with LptD, at the outer membrane. {ECO 0000269|PubMed 22668317}. # EcoGene EG12618 lptA # FUNCTION LPTA_ECOLI Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm. {ECO 0000255|HAMAP-Rule MF_01914, ECO 0000269|PubMed 16765569, ECO 0000269|PubMed 17056748, ECO 0000269|PubMed 18424520, ECO 0000269|PubMed 18480051, ECO 0000269|PubMed 21169485}. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_component GO:0042597 periplasmic space; IDA:EcoCyc. # GO_function GO:0001530 lipopolysaccharide binding; IEA:InterPro. # GO_function GO:0017089 glycolipid transporter activity; IMP:EcoCyc. # GO_process GO:0015920 lipopolysaccharide transport; IMP:EcoCyc. # GO_process GO:0043165 Gram-negative-bacterium-type cell outer membrane assembly; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008289 lipid binding # GOslim_process GO:0006810 transport # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0061024 membrane organization # HAMAP MF_01914 LPS_assembly_LptA # INDUCTION Transcriptionally regulated by sigma-E factor. {ECO:0000269|PubMed 17056748}. # INTERACTION LPTA_ECOLI P0ADV9 lptC; NbExp=3; IntAct=EBI-1132001, EBI-1131969; P31554 lptD; NbExp=3; IntAct=EBI-1132001, EBI-549369; # IntAct P0ADV1 5 # InterPro IPR005653 OstA-like_N # InterPro IPR014340 LptA # KEGG_Brite ko02000 Transporters # Organism LPTA_ECOLI Escherichia coli (strain K12) # PATRIC 32121820 VBIEscCol129921_3294 # PDB 2R19 X-ray; 2.16 A; A/B=27-185 # PDB 2R1A X-ray; 3.26 A; A/B/C/D/E/F/G/H=27-185 # PIR B65111 B65111 # Pfam PF03968 OstA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Lipopolysaccharide export system protein LptA {ECO:0000255|HAMAP-Rule MF_01914} # RefSeq NP_417667 NC_000913.3 # RefSeq WP_000669785 NZ_LN832404.1 # SIMILARITY Belongs to the LptA family. {ECO:0000255|HAMAP- Rule MF_01914}. # SUBCELLULAR LOCATION LPTA_ECOLI Periplasm {ECO 0000255|HAMAP-Rule MF_01914, ECO 0000269|PubMed 17056748, ECO 0000269|PubMed 18480051, ECO 0000269|PubMed 20446753}. Note=Associates with both the inner membrane and the outer membrane. # SUBUNIT LPTA_ECOLI Component of the lipopolysaccharide transport and assembly complex. Can form head-to-tail homodimers and oligomers. Interacts with LptC, LptD and with the lipid A domain of LPS. {ECO 0000255|HAMAP-Rule MF_01914, ECO 0000269|PubMed 18424520, ECO 0000269|PubMed 18480051, ECO 0000269|PubMed 18534617, ECO 0000269|PubMed 20446753, ECO 0000269|PubMed 21169485, ECO 0000269|PubMed 21195693, ECO 0000269|PubMed 22668317}. # TCDB 1.B.42.1 the outer membrane lipopolysaccharide export porin (lps-ep) family # TIGRFAMs TIGR03002 outer_YhbN_LptA # eggNOG COG1934 LUCA # eggNOG ENOG4105WI0 Bacteria BLAST swissprot:LPTA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LPTA_ECOLI BioCyc ECOL316407:JW3167-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3167-MONOMER BioCyc EcoCyc:YHBN-MONOMER http://biocyc.org/getid?id=EcoCyc:YHBN-MONOMER BioCyc MetaCyc:YHBN-MONOMER http://biocyc.org/getid?id=MetaCyc:YHBN-MONOMER COG COG1934 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1934 DIP DIP-12262N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12262N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1016/j.bbrc.2010.12.121 http://dx.doi.org/10.1016/j.bbrc.2010.12.121 DOI 10.1016/j.jmb.2008.04.045 http://dx.doi.org/10.1016/j.jmb.2008.04.045 DOI 10.1016/j.resmic.2005.11.014 http://dx.doi.org/10.1016/j.resmic.2005.11.014 DOI 10.1021/bi100493e http://dx.doi.org/10.1021/bi100493e DOI 10.1021/bi300592c http://dx.doi.org/10.1021/bi300592c DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.270.9.4822 http://dx.doi.org/10.1074/jbc.270.9.4822 DOI 10.1074/jbc.M802503200 http://dx.doi.org/10.1074/jbc.M802503200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00270-08 http://dx.doi.org/10.1128/JB.00270-08 DOI 10.1128/JB.01037-10 http://dx.doi.org/10.1128/JB.01037-10 DOI 10.1128/JB.01126-06 http://dx.doi.org/10.1128/JB.01126-06 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U12684 http://www.ebi.ac.uk/ena/data/view/U12684 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2502 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2502 EcoGene EG12618 http://www.ecogene.org/geneInfo.php?eg_id=EG12618 EnsemblBacteria AAC76232 http://www.ensemblgenomes.org/id/AAC76232 EnsemblBacteria AAC76232 http://www.ensemblgenomes.org/id/AAC76232 EnsemblBacteria BAE77244 http://www.ensemblgenomes.org/id/BAE77244 EnsemblBacteria BAE77244 http://www.ensemblgenomes.org/id/BAE77244 EnsemblBacteria BAE77244 http://www.ensemblgenomes.org/id/BAE77244 EnsemblBacteria b3200 http://www.ensemblgenomes.org/id/b3200 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0001530 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001530 GO_function GO:0017089 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017089 GO_process GO:0015920 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015920 GO_process GO:0043165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043165 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0061024 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024 GeneID 947920 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947920 HAMAP MF_01914 http://hamap.expasy.org/unirule/MF_01914 HOGENOM HOG000264762 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000264762&db=HOGENOM6 InParanoid P0ADV1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADV1 IntAct P0ADV1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADV1* InterPro IPR005653 http://www.ebi.ac.uk/interpro/entry/IPR005653 InterPro IPR014340 http://www.ebi.ac.uk/interpro/entry/IPR014340 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3167 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3167 KEGG_Gene eco:b3200 http://www.genome.jp/dbget-bin/www_bget?eco:b3200 KEGG_Orthology KO:K09774 http://www.genome.jp/dbget-bin/www_bget?KO:K09774 OMA NGQKKSN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NGQKKSN PDB 2R19 http://www.ebi.ac.uk/pdbe-srv/view/entry/2R19 PDB 2R1A http://www.ebi.ac.uk/pdbe-srv/view/entry/2R1A PDBsum 2R19 http://www.ebi.ac.uk/pdbsum/2R19 PDBsum 2R1A http://www.ebi.ac.uk/pdbsum/2R1A PSORT swissprot:LPTA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LPTA_ECOLI PSORT-B swissprot:LPTA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LPTA_ECOLI PSORT2 swissprot:LPTA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LPTA_ECOLI Pfam PF03968 http://pfam.xfam.org/family/PF03968 Phobius swissprot:LPTA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LPTA_ECOLI PhylomeDB P0ADV1 http://phylomedb.org/?seqid=P0ADV1 ProteinModelPortal P0ADV1 http://www.proteinmodelportal.org/query/uniprot/P0ADV1 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16765569 http://www.ncbi.nlm.nih.gov/pubmed/16765569 PubMed 17056748 http://www.ncbi.nlm.nih.gov/pubmed/17056748 PubMed 18424520 http://www.ncbi.nlm.nih.gov/pubmed/18424520 PubMed 18480051 http://www.ncbi.nlm.nih.gov/pubmed/18480051 PubMed 18534617 http://www.ncbi.nlm.nih.gov/pubmed/18534617 PubMed 20446753 http://www.ncbi.nlm.nih.gov/pubmed/20446753 PubMed 21169485 http://www.ncbi.nlm.nih.gov/pubmed/21169485 PubMed 21195693 http://www.ncbi.nlm.nih.gov/pubmed/21195693 PubMed 22668317 http://www.ncbi.nlm.nih.gov/pubmed/22668317 PubMed 7876255 http://www.ncbi.nlm.nih.gov/pubmed/7876255 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_417667 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417667 RefSeq WP_000669785 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000669785 SMR P0ADV1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADV1 STRING 511145.b3200 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3200&targetmode=cogs STRING COG1934 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1934&targetmode=cogs TCDB 1.B.42.1 http://www.tcdb.org/search/result.php?tc=1.B.42.1 TIGRFAMs TIGR03002 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03002 UniProtKB LPTA_ECOLI http://www.uniprot.org/uniprot/LPTA_ECOLI UniProtKB-AC P0ADV1 http://www.uniprot.org/uniprot/P0ADV1 charge swissprot:LPTA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LPTA_ECOLI eggNOG COG1934 http://eggnogapi.embl.de/nog_data/html/tree/COG1934 eggNOG ENOG4105WI0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105WI0 epestfind swissprot:LPTA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LPTA_ECOLI garnier swissprot:LPTA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LPTA_ECOLI helixturnhelix swissprot:LPTA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LPTA_ECOLI hmoment swissprot:LPTA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LPTA_ECOLI iep swissprot:LPTA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LPTA_ECOLI inforesidue swissprot:LPTA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LPTA_ECOLI octanol swissprot:LPTA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LPTA_ECOLI pepcoil swissprot:LPTA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LPTA_ECOLI pepdigest swissprot:LPTA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LPTA_ECOLI pepinfo swissprot:LPTA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LPTA_ECOLI pepnet swissprot:LPTA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LPTA_ECOLI pepstats swissprot:LPTA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LPTA_ECOLI pepwheel swissprot:LPTA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LPTA_ECOLI pepwindow swissprot:LPTA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LPTA_ECOLI sigcleave swissprot:LPTA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LPTA_ECOLI ## Database ID URL or Descriptions # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG12546 yjhD # InterPro IPR031939 Adhesin_E-like # Organism YJHD_ECOLI Escherichia coli (strain K12) # PIR S56506 S56506 # Pfam PF16747 Adhesin_E # Proteomes UP000000625 Chromosome # RecName YJHD_ECOLI Putative uncharacterized protein YjhD # SEQUENCE CAUTION Sequence=AAA97177.1; Type=Erroneous initiation; Evidence={ECO 0000305}; BLAST swissprot:YJHD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJHD_ECOLI BioCyc EcoCyc:G7902-MONOMER http://biocyc.org/getid?id=EcoCyc:G7902-MONOMER DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2434 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2434 EcoGene EG12546 http://www.ecogene.org/geneInfo.php?eg_id=EG12546 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv HOGENOM HOG000081500 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000081500&db=HOGENOM6 InterPro IPR031939 http://www.ebi.ac.uk/interpro/entry/IPR031939 OMA MVNCETK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MVNCETK PSORT swissprot:YJHD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJHD_ECOLI PSORT-B swissprot:YJHD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJHD_ECOLI PSORT2 swissprot:YJHD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJHD_ECOLI Pfam PF16747 http://pfam.xfam.org/family/PF16747 Phobius swissprot:YJHD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJHD_ECOLI ProteinModelPortal P39354 http://www.proteinmodelportal.org/query/uniprot/P39354 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 UniProtKB YJHD_ECOLI http://www.uniprot.org/uniprot/YJHD_ECOLI UniProtKB-AC P39354 http://www.uniprot.org/uniprot/P39354 charge swissprot:YJHD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJHD_ECOLI epestfind swissprot:YJHD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJHD_ECOLI garnier swissprot:YJHD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJHD_ECOLI helixturnhelix swissprot:YJHD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJHD_ECOLI hmoment swissprot:YJHD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJHD_ECOLI iep swissprot:YJHD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJHD_ECOLI inforesidue swissprot:YJHD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJHD_ECOLI octanol swissprot:YJHD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJHD_ECOLI pepcoil swissprot:YJHD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJHD_ECOLI pepdigest swissprot:YJHD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJHD_ECOLI pepinfo swissprot:YJHD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJHD_ECOLI pepnet swissprot:YJHD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJHD_ECOLI pepstats swissprot:YJHD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJHD_ECOLI pepwheel swissprot:YJHD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJHD_ECOLI pepwindow swissprot:YJHD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJHD_ECOLI sigcleave swissprot:YJHD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJHD_ECOLI ## Database ID URL or Descriptions # BioGrid 4263020 8 # EcoGene EG11310 ydbD # GO_process GO:0051595 response to methylglyoxal; IMP:EcoCyc. # GOslim_process GO:0008150 biological_process # IntAct P25907 2 # InterPro IPR024497 DUF2773 # Organism YDBD_ECOLI Escherichia coli (strain K12) # PATRIC 32118100 VBIEscCol129921_1470 # PIR B64892 B64892 # Pfam PF10971 DUF2773 # ProDom PD029376 PD029376 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDBD_ECOLI Uncharacterized protein YdbD # RefSeq NP_415925 NC_000913.3 # RefSeq WP_000910026 NZ_LN832404.1 # SIMILARITY To E.coli YkiA. {ECO 0000305}. BLAST swissprot:YDBD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDBD_ECOLI BioCyc ECOL316407:JW5221-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5221-MONOMER BioCyc EcoCyc:EG11310-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11310-MONOMER DOI 10.1016/0300-9084(91)90166-X http://dx.doi.org/10.1016/0300-9084(91)90166-X DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X62680 http://www.ebi.ac.uk/ena/data/view/X62680 EchoBASE EB1286 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1286 EcoGene EG11310 http://www.ecogene.org/geneInfo.php?eg_id=EG11310 EnsemblBacteria AAC74489 http://www.ensemblgenomes.org/id/AAC74489 EnsemblBacteria AAC74489 http://www.ensemblgenomes.org/id/AAC74489 EnsemblBacteria BAA15022 http://www.ensemblgenomes.org/id/BAA15022 EnsemblBacteria BAA15022 http://www.ensemblgenomes.org/id/BAA15022 EnsemblBacteria BAA15022 http://www.ensemblgenomes.org/id/BAA15022 EnsemblBacteria b1407 http://www.ensemblgenomes.org/id/b1407 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0051595 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051595 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 945983 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945983 HOGENOM HOG000009727 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009727&db=HOGENOM6 IntAct P25907 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P25907* InterPro IPR024497 http://www.ebi.ac.uk/interpro/entry/IPR024497 KEGG_Gene ecj:JW5221 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5221 KEGG_Gene eco:b1407 http://www.genome.jp/dbget-bin/www_bget?eco:b1407 OMA EGWDFLE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EGWDFLE PSORT swissprot:YDBD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDBD_ECOLI PSORT-B swissprot:YDBD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDBD_ECOLI PSORT2 swissprot:YDBD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDBD_ECOLI Pfam PF10971 http://pfam.xfam.org/family/PF10971 Phobius swissprot:YDBD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDBD_ECOLI ProteinModelPortal P25907 http://www.proteinmodelportal.org/query/uniprot/P25907 PubMed 1665988 http://www.ncbi.nlm.nih.gov/pubmed/1665988 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415925 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415925 RefSeq WP_000910026 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000910026 SMR P25907 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P25907 STRING 511145.b1407 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1407&targetmode=cogs UniProtKB YDBD_ECOLI http://www.uniprot.org/uniprot/YDBD_ECOLI UniProtKB-AC P25907 http://www.uniprot.org/uniprot/P25907 charge swissprot:YDBD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDBD_ECOLI epestfind swissprot:YDBD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDBD_ECOLI garnier swissprot:YDBD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDBD_ECOLI helixturnhelix swissprot:YDBD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDBD_ECOLI hmoment swissprot:YDBD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDBD_ECOLI iep swissprot:YDBD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDBD_ECOLI inforesidue swissprot:YDBD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDBD_ECOLI octanol swissprot:YDBD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDBD_ECOLI pepcoil swissprot:YDBD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDBD_ECOLI pepdigest swissprot:YDBD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDBD_ECOLI pepinfo swissprot:YDBD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDBD_ECOLI pepnet swissprot:YDBD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDBD_ECOLI pepstats swissprot:YDBD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDBD_ECOLI pepwheel swissprot:YDBD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDBD_ECOLI pepwindow swissprot:YDBD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDBD_ECOLI sigcleave swissprot:YDBD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDBD_ECOLI ## Database ID URL or Descriptions # AltName PGAC_ECOLI Biofilm PGA synthesis protein PgaC # AltName PGAC_ECOLI N-acetylglucosaminyltransferase PgaC # BioGrid 4260056 253 # CAZy GT2 Glycosyltransferase Family 2 # DISRUPTION PHENOTYPE PGAC_ECOLI Cells lacking this gene do not synthesize PGA. {ECO 0000269|PubMed 15090514, ECO 0000269|PubMed 18359807}. # EcoGene EG13863 pgaC # FUNCTION PGAC_ECOLI Probable N-acetylglucosaminyltransferase that catalyzes the polymerization of single monomer units of UDP-N- acetylglucosamine to produce the linear homopolymer poly-beta-1,6- N-acetyl-D-glucosamine (PGA), a biofilm adhesin polysaccharide. {ECO 0000269|PubMed 15090514, ECO 0000269|PubMed 18359807}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0008375 acetylglucosaminyltransferase activity; IMP:EcoCyc. # GO_process GO:0043708 cell adhesion involved in biofilm formation; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_process GO:0007155 cell adhesion # Gene3D 3.90.550.10 -; 1. # INTERACTION PGAC_ECOLI P69432 pgaD; NbExp=2; IntAct=EBI-561450, EBI-562069; # IntAct P75905 6 # InterPro IPR001173 Glyco_trans_2-like # InterPro IPR023853 PGA_PgaC/IcaA # InterPro IPR029044 Nucleotide-diphossugar_trans # KEGG_Brite ko01000 Enzymes # Organism PGAC_ECOLI Escherichia coli (strain K12) # PATRIC 32117277 VBIEscCol129921_1062 # PIR D64844 D64844 # Pfam PF00535 Glycos_transf_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PGAC_ECOLI Poly-beta-1,6-N-acetyl-D-glucosamine synthase # RefSeq NP_415541 NC_000913.3 # SIMILARITY Belongs to the glycosyltransferase 2 family. {ECO 0000305}. # SUBCELLULAR LOCATION PGAC_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # SUPFAM SSF53448 SSF53448 # TCDB 4.D.1.1 the putative vectorial glycosyl polymerization (vgp) family # TIGRFAMs TIGR03937 PgaC_IcaA # eggNOG COG1215 LUCA # eggNOG ENOG4105CND Bacteria BLAST swissprot:PGAC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PGAC_ECOLI BioCyc ECOL316407:JW1007-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1007-MONOMER BioCyc EcoCyc:G6529-MONOMER http://biocyc.org/getid?id=EcoCyc:G6529-MONOMER BioCyc MetaCyc:G6529-MONOMER http://biocyc.org/getid?id=MetaCyc:G6529-MONOMER COG COG1215 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1215 DIP DIP-11512N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11512N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01920-07 http://dx.doi.org/10.1128/JB.01920-07 DOI 10.1128/JB.186.9.2724-2734.2004 http://dx.doi.org/10.1128/JB.186.9.2724-2734.2004 EC_number EC:2.4.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.4.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.4.1.- http://enzyme.expasy.org/EC/2.4.1.- EchoBASE EB3623 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3623 EcoGene EG13863 http://www.ecogene.org/geneInfo.php?eg_id=EG13863 EnsemblBacteria AAC74107 http://www.ensemblgenomes.org/id/AAC74107 EnsemblBacteria AAC74107 http://www.ensemblgenomes.org/id/AAC74107 EnsemblBacteria BAA35803 http://www.ensemblgenomes.org/id/BAA35803 EnsemblBacteria BAA35803 http://www.ensemblgenomes.org/id/BAA35803 EnsemblBacteria BAA35803 http://www.ensemblgenomes.org/id/BAA35803 EnsemblBacteria b1022 http://www.ensemblgenomes.org/id/b1022 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008375 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008375 GO_process GO:0043708 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043708 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 Gene3D 3.90.550.10 http://www.cathdb.info/version/latest/superfamily/3.90.550.10 GeneID 945606 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945606 HOGENOM HOG000170129 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000170129&db=HOGENOM6 InParanoid P75905 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75905 IntAct P75905 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75905* IntEnz 2.4.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.1 InterPro IPR001173 http://www.ebi.ac.uk/interpro/entry/IPR001173 InterPro IPR023853 http://www.ebi.ac.uk/interpro/entry/IPR023853 InterPro IPR029044 http://www.ebi.ac.uk/interpro/entry/IPR029044 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1007 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1007 KEGG_Gene eco:b1022 http://www.genome.jp/dbget-bin/www_bget?eco:b1022 KEGG_Orthology KO:K11936 http://www.genome.jp/dbget-bin/www_bget?KO:K11936 MINT MINT-1234361 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1234361 OMA WPPVTIL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WPPVTIL PSORT swissprot:PGAC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PGAC_ECOLI PSORT-B swissprot:PGAC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PGAC_ECOLI PSORT2 swissprot:PGAC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PGAC_ECOLI Pfam PF00535 http://pfam.xfam.org/family/PF00535 Phobius swissprot:PGAC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PGAC_ECOLI PhylomeDB P75905 http://phylomedb.org/?seqid=P75905 ProteinModelPortal P75905 http://www.proteinmodelportal.org/query/uniprot/P75905 PubMed 15090514 http://www.ncbi.nlm.nih.gov/pubmed/15090514 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18359807 http://www.ncbi.nlm.nih.gov/pubmed/18359807 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415541 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415541 STRING 511145.b1022 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1022&targetmode=cogs STRING COG1215 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1215&targetmode=cogs SUPFAM SSF53448 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53448 TCDB 4.D.1.1 http://www.tcdb.org/search/result.php?tc=4.D.1.1 TIGRFAMs TIGR03937 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03937 UniProtKB PGAC_ECOLI http://www.uniprot.org/uniprot/PGAC_ECOLI UniProtKB-AC P75905 http://www.uniprot.org/uniprot/P75905 charge swissprot:PGAC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PGAC_ECOLI eggNOG COG1215 http://eggnogapi.embl.de/nog_data/html/tree/COG1215 eggNOG ENOG4105CND http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CND epestfind swissprot:PGAC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PGAC_ECOLI garnier swissprot:PGAC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PGAC_ECOLI helixturnhelix swissprot:PGAC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PGAC_ECOLI hmoment swissprot:PGAC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PGAC_ECOLI iep swissprot:PGAC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PGAC_ECOLI inforesidue swissprot:PGAC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PGAC_ECOLI octanol swissprot:PGAC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PGAC_ECOLI pepcoil swissprot:PGAC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PGAC_ECOLI pepdigest swissprot:PGAC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PGAC_ECOLI pepinfo swissprot:PGAC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PGAC_ECOLI pepnet swissprot:PGAC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PGAC_ECOLI pepstats swissprot:PGAC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PGAC_ECOLI pepwheel swissprot:PGAC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PGAC_ECOLI pepwindow swissprot:PGAC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PGAC_ECOLI sigcleave swissprot:PGAC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PGAC_ECOLI ## Database ID URL or Descriptions # AltName MTR_ECOLI Tryptophan permease # BioGrid 4259278 178 # EcoGene EG10617 mtr # FUNCTION MTR_ECOLI Involved in transporting tryptophan across the cytoplasmic membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoliWiki. # GO_function GO:0005300 high-affinity tryptophan transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0015293 symporter activity; IDA:EcoCyc. # GO_function GO:0022804 active transmembrane transporter activity; EXP:EcoCyc. # GO_process GO:0003333 amino acid transmembrane transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0055085 transmembrane transport # INDUCTION MTR_ECOLI By phenylalanine under the control of regulatory protein TyrR. # InterPro IPR002091 ArAA_permease # InterPro IPR013059 Trp_tyr_transpt # InterPro IPR013061 Trp/try_permease_CS # InterPro IPR018227 Tryptophan/tyrosine_permease # KEGG_Brite ko02000 Transporters # Organism MTR_ECOLI Escherichia coli (strain K12) # PATRIC 32121740 VBIEscCol129921_3256 # PIR A39187 A39187 # PRINTS PR00166 AROAAPRMEASE # PROSITE PS00594 AROMATIC_AA_PERMEASE_1 # Pfam PF03222 Trp_Tyr_perm # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MTR_ECOLI Tryptophan-specific transport protein # RefSeq NP_417630 NC_000913.3 # RefSeq WP_000224351 NZ_LN832404.1 # SIMILARITY Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION MTR_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.42.1 the hydroxy/aromatic amino acid permease (haaap) family # TIGRFAMs TIGR00837 araaP # eggNOG COG0814 LUCA # eggNOG ENOG4105CIC Bacteria BLAST swissprot:MTR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MTR_ECOLI BioCyc ECOL316407:JW3130-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3130-MONOMER BioCyc EcoCyc:MTR-MONOMER http://biocyc.org/getid?id=EcoCyc:MTR-MONOMER BioCyc MetaCyc:MTR-MONOMER http://biocyc.org/getid?id=MetaCyc:MTR-MONOMER COG COG0814 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0814 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M58338 http://www.ebi.ac.uk/ena/data/view/M58338 EMBL M59862 http://www.ebi.ac.uk/ena/data/view/M59862 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB0612 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0612 EcoGene EG10617 http://www.ecogene.org/geneInfo.php?eg_id=EG10617 EnsemblBacteria AAC76195 http://www.ensemblgenomes.org/id/AAC76195 EnsemblBacteria AAC76195 http://www.ensemblgenomes.org/id/AAC76195 EnsemblBacteria BAE77207 http://www.ensemblgenomes.org/id/BAE77207 EnsemblBacteria BAE77207 http://www.ensemblgenomes.org/id/BAE77207 EnsemblBacteria BAE77207 http://www.ensemblgenomes.org/id/BAE77207 EnsemblBacteria b3161 http://www.ensemblgenomes.org/id/b3161 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0005300 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005300 GO_function GO:0015293 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293 GO_function GO:0022804 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022804 GO_process GO:0003333 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003333 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 947675 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947675 HOGENOM HOG000269674 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000269674&db=HOGENOM6 InParanoid P0AAD2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAD2 InterPro IPR002091 http://www.ebi.ac.uk/interpro/entry/IPR002091 InterPro IPR013059 http://www.ebi.ac.uk/interpro/entry/IPR013059 InterPro IPR013061 http://www.ebi.ac.uk/interpro/entry/IPR013061 InterPro IPR018227 http://www.ebi.ac.uk/interpro/entry/IPR018227 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3130 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3130 KEGG_Gene eco:b3161 http://www.genome.jp/dbget-bin/www_bget?eco:b3161 KEGG_Orthology KO:K03835 http://www.genome.jp/dbget-bin/www_bget?KO:K03835 OMA IWLLGTM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IWLLGTM PRINTS PR00166 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00166 PROSITE PS00594 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00594 PSORT swissprot:MTR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MTR_ECOLI PSORT-B swissprot:MTR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MTR_ECOLI PSORT2 swissprot:MTR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MTR_ECOLI Pfam PF03222 http://pfam.xfam.org/family/PF03222 Phobius swissprot:MTR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MTR_ECOLI PhylomeDB P0AAD2 http://phylomedb.org/?seqid=P0AAD2 ProteinModelPortal P0AAD2 http://www.proteinmodelportal.org/query/uniprot/P0AAD2 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1904443 http://www.ncbi.nlm.nih.gov/pubmed/1904443 PubMed 1987112 http://www.ncbi.nlm.nih.gov/pubmed/1987112 PubMed 2061290 http://www.ncbi.nlm.nih.gov/pubmed/2061290 PubMed 7814318 http://www.ncbi.nlm.nih.gov/pubmed/7814318 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417630 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417630 RefSeq WP_000224351 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000224351 STRING 511145.b3161 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3161&targetmode=cogs STRING COG0814 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0814&targetmode=cogs TCDB 2.A.42.1 http://www.tcdb.org/search/result.php?tc=2.A.42.1 TIGRFAMs TIGR00837 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00837 UniProtKB MTR_ECOLI http://www.uniprot.org/uniprot/MTR_ECOLI UniProtKB-AC P0AAD2 http://www.uniprot.org/uniprot/P0AAD2 charge swissprot:MTR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MTR_ECOLI eggNOG COG0814 http://eggnogapi.embl.de/nog_data/html/tree/COG0814 eggNOG ENOG4105CIC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CIC epestfind swissprot:MTR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MTR_ECOLI garnier swissprot:MTR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MTR_ECOLI helixturnhelix swissprot:MTR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MTR_ECOLI hmoment swissprot:MTR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MTR_ECOLI iep swissprot:MTR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MTR_ECOLI inforesidue swissprot:MTR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MTR_ECOLI octanol swissprot:MTR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MTR_ECOLI pepcoil swissprot:MTR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MTR_ECOLI pepdigest swissprot:MTR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MTR_ECOLI pepinfo swissprot:MTR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MTR_ECOLI pepnet swissprot:MTR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MTR_ECOLI pepstats swissprot:MTR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MTR_ECOLI pepwheel swissprot:MTR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MTR_ECOLI pepwindow swissprot:MTR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MTR_ECOLI sigcleave swissprot:MTR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MTR_ECOLI ## Database ID URL or Descriptions # BioGrid 4262480 197 # CATALYTIC ACTIVITY FRLB_ECOLI Fructoselysine 6-phosphate + H(2)O = glucose 6-phosphate + L-lysine. # EcoGene EG12909 frlB # FUNCTION FRLB_ECOLI Catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine. {ECO 0000269|PubMed 12147680}. # GO_function GO:0016787 hydrolase activity; IEA:UniProtKB-KW. # GO_function GO:0030246 carbohydrate binding; IEA:InterPro. # GO_process GO:0005975 carbohydrate metabolic process; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0005975 carbohydrate metabolic process # InterPro IPR001347 SIS # KEGG_Brite ko01000 Enzymes # Organism FRLB_ECOLI Escherichia coli (strain K12) # PATHWAY Carbohydrate metabolism; fructoselysine degradation; D- glucose 6-phosphate and lysine from fructoselysine step 2/2. # PATRIC 32122176 VBIEscCol129921_3465 # PIR F65131 F65131 # PROSITE PS51464 SIS; 2 # Pfam PF01380 SIS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FRLB_ECOLI Fructoselysine 6-phosphate deglycase # RefSeq NP_417830 NC_000913.3 # RefSeq WP_001295163 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA58168.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Contains 2 SIS domains. {ECO:0000255|PROSITE- ProRule PRU00797}. # SUBUNIT Homododecamer. {ECO 0000305}. # UniPathway UPA00784 UER00770 # eggNOG COG2222 LUCA # eggNOG ENOG4107R1S Bacteria BLAST swissprot:FRLB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FRLB_ECOLI BioCyc ECOL316407:JW5700-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5700-MONOMER BioCyc EcoCyc:G7723-MONOMER http://biocyc.org/getid?id=EcoCyc:G7723-MONOMER BioCyc MetaCyc:G7723-MONOMER http://biocyc.org/getid?id=MetaCyc:G7723-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M200863200 http://dx.doi.org/10.1074/jbc.M200863200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.5.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.5.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 3.5.-.- http://enzyme.expasy.org/EC/3.5.-.- EchoBASE EB2746 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2746 EcoGene EG12909 http://www.ecogene.org/geneInfo.php?eg_id=EG12909 EnsemblBacteria AAC76396 http://www.ensemblgenomes.org/id/AAC76396 EnsemblBacteria AAC76396 http://www.ensemblgenomes.org/id/AAC76396 EnsemblBacteria BAE77919 http://www.ensemblgenomes.org/id/BAE77919 EnsemblBacteria BAE77919 http://www.ensemblgenomes.org/id/BAE77919 EnsemblBacteria BAE77919 http://www.ensemblgenomes.org/id/BAE77919 EnsemblBacteria b3371 http://www.ensemblgenomes.org/id/b3371 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016787 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016787 GO_function GO:0030246 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030246 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GeneID 947875 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947875 HOGENOM HOG000005028 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000005028&db=HOGENOM6 InParanoid P0AC00 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AC00 IntEnz 3.5 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5 InterPro IPR001347 http://www.ebi.ac.uk/interpro/entry/IPR001347 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5700 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5700 KEGG_Gene eco:b3371 http://www.genome.jp/dbget-bin/www_bget?eco:b3371 KEGG_Orthology KO:K10708 http://www.genome.jp/dbget-bin/www_bget?KO:K10708 KEGG_Reaction rn:R08125 http://www.genome.jp/dbget-bin/www_bget?rn:R08125 OMA SKSIHAA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SKSIHAA PROSITE PS51464 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51464 PSORT swissprot:FRLB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FRLB_ECOLI PSORT-B swissprot:FRLB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FRLB_ECOLI PSORT2 swissprot:FRLB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FRLB_ECOLI Pfam PF01380 http://pfam.xfam.org/family/PF01380 Phobius swissprot:FRLB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FRLB_ECOLI PhylomeDB P0AC00 http://phylomedb.org/?seqid=P0AC00 ProteinModelPortal P0AC00 http://www.proteinmodelportal.org/query/uniprot/P0AC00 PubMed 12147680 http://www.ncbi.nlm.nih.gov/pubmed/12147680 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417830 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417830 RefSeq WP_001295163 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295163 SMR P0AC00 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AC00 STRING 511145.b3371 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3371&targetmode=cogs UniProtKB FRLB_ECOLI http://www.uniprot.org/uniprot/FRLB_ECOLI UniProtKB-AC P0AC00 http://www.uniprot.org/uniprot/P0AC00 charge swissprot:FRLB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FRLB_ECOLI eggNOG COG2222 http://eggnogapi.embl.de/nog_data/html/tree/COG2222 eggNOG ENOG4107R1S http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107R1S epestfind swissprot:FRLB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FRLB_ECOLI garnier swissprot:FRLB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FRLB_ECOLI helixturnhelix swissprot:FRLB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FRLB_ECOLI hmoment swissprot:FRLB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FRLB_ECOLI iep swissprot:FRLB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FRLB_ECOLI inforesidue swissprot:FRLB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FRLB_ECOLI octanol swissprot:FRLB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FRLB_ECOLI pepcoil swissprot:FRLB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FRLB_ECOLI pepdigest swissprot:FRLB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FRLB_ECOLI pepinfo swissprot:FRLB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FRLB_ECOLI pepnet swissprot:FRLB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FRLB_ECOLI pepstats swissprot:FRLB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FRLB_ECOLI pepwheel swissprot:FRLB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FRLB_ECOLI pepwindow swissprot:FRLB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FRLB_ECOLI sigcleave swissprot:FRLB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FRLB_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES GLYA_ECOLI Kinetic parameters KM=7 uM for tetrahydrofolate {ECO 0000269|PubMed 12773539, ECO 0000269|PubMed 19883126}; KM=140 uM for serine {ECO 0000269|PubMed 12773539, ECO 0000269|PubMed 19883126}; KM=300 uM for serine {ECO 0000269|PubMed 12773539, ECO 0000269|PubMed 19883126}; # BRENDA 2.1.2 2026 # BRENDA 4.1.2.48 2026 # BioGrid 4261314 203 # CATALYTIC ACTIVITY GLYA_ECOLI 5,10-methylenetetrahydrofolate + glycine + H(2)O = tetrahydrofolate + L-serine. # CDD cd00378 SHMT # COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI 597326; # EcoGene EG10408 glyA # FUNCTION GLYA_ECOLI Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. Thus, is able to catalyze the cleavage of allothreonine and 3- phenylserine. Also catalyzes the irreversible conversion of 5,10- methenyltetrahydrofolate to 5-formyltetrahydrofolate. {ECO 0000269|PubMed 6190704}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0004372 glycine hydroxymethyltransferase activity; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IDA:EcoliWiki. # GO_function GO:0030170 pyridoxal phosphate binding; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IPI:IntAct. # GO_process GO:0006546 glycine catabolic process; IMP:EcoCyc. # GO_process GO:0006565 L-serine catabolic process; IDA:EcoCyc. # GO_process GO:0019264 glycine biosynthetic process from serine; IDA:EcoCyc. # GO_process GO:0035999 tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.640.10 -; 1. # Gene3D 3.90.1150.10 -; 1. # HAMAP MF_00051 SHMT # INDUCTION By CsgD. {ECO:0000269|PubMed 12624214}. # INTERACTION GLYA_ECOLI Self; NbExp=5; IntAct=EBI-909080, EBI-909080; # IntAct P0A825 7 # InterPro IPR001085 Ser_HO-MeTrfase # InterPro IPR015421 PyrdxlP-dep_Trfase_major_sub1 # InterPro IPR015422 PyrdxlP-dep_Trfase_major_sub2 # InterPro IPR015424 PyrdxlP-dep_Trfase # InterPro IPR019798 Ser_HO-MeTrfase_PLP_BS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00260 Glycine, serine and threonine metabolism # KEGG_Pathway ko00460 Cyanoamino acid metabolism # KEGG_Pathway ko00630 Glyoxylate and dicarboxylate metabolism # KEGG_Pathway ko00670 One carbon pool by folate # KEGG_Pathway ko00680 Methane metabolism # Organism GLYA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11680 PTHR11680 # PATHWAY Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine step 1/1. # PATHWAY GLYA_ECOLI One-carbon metabolism; tetrahydrofolate interconversion. # PATRIC 32120501 VBIEscCol129921_2653 # PDB 1DFO X-ray; 2.40 A; A/B/C/D=1-417 # PDB 1EQB X-ray; 2.70 A; A/B/C/D=1-417 # PDB 3G8M X-ray; 3.30 A; A=1-417 # PIR A00559 XYECS # PIRSF PIRSF000412 SHMT # PROSITE PS00096 SHMT # Pfam PF00464 SHMT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLYA_ECOLI Serine hydroxymethyltransferase # RefSeq NP_417046 NC_000913.3 # RefSeq WP_000919159 NZ_LN832404.1 # SIMILARITY Belongs to the SHMT family. {ECO 0000305}. # SUBCELLULAR LOCATION GLYA_ECOLI Cytoplasm. # SUBUNIT GLYA_ECOLI Homodimer. {ECO 0000269|PubMed 10656824, ECO 0000269|PubMed 10858298, ECO 0000269|PubMed 19019081, ECO 0000269|PubMed 19883126}. # SUPFAM SSF53383 SSF53383 # UniPathway UPA00288 UER01023 # eggNOG COG0112 LUCA # eggNOG ENOG4105C65 Bacteria BLAST swissprot:GLYA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLYA_ECOLI BioCyc ECOL316407:JW2535-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2535-MONOMER BioCyc EcoCyc:GLYOHMETRANS-MONOMER http://biocyc.org/getid?id=EcoCyc:GLYOHMETRANS-MONOMER BioCyc MetaCyc:GLYOHMETRANS-MONOMER http://biocyc.org/getid?id=MetaCyc:GLYOHMETRANS-MONOMER COG COG0112 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0112 DIP DIP-36205N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36205N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1999.3453 http://dx.doi.org/10.1006/jmbi.1999.3453 DOI 10.1007/BF00273586 http://dx.doi.org/10.1007/BF00273586 DOI 10.1016/0378-1119(83)90059-8 http://dx.doi.org/10.1016/0378-1119(83)90059-8 DOI 10.1021/bi000032z http://dx.doi.org/10.1021/bi000032z DOI 10.1021/bi901568b http://dx.doi.org/10.1021/bi901568b DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nchembio.495 http://dx.doi.org/10.1038/nchembio.495 DOI 10.1042/BJ20061681 http://dx.doi.org/10.1042/BJ20061681 DOI 10.1074/jbc.M303779200 http://dx.doi.org/10.1074/jbc.M303779200 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/nar/11.7.2065 http://dx.doi.org/10.1093/nar/11.7.2065 DOI 10.1099/mic.0.25841-0 http://dx.doi.org/10.1099/mic.0.25841-0 DOI 10.1111/j.1432-1033.1994.00395.x http://dx.doi.org/10.1111/j.1432-1033.1994.00395.x DOI 10.1111/j.1742-4658.2008.06761.x http://dx.doi.org/10.1111/j.1742-4658.2008.06761.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.2.1 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.2.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01620 http://www.ebi.ac.uk/ena/data/view/J01620 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00283 http://www.ebi.ac.uk/ena/data/view/V00283 ENZYME 2.1.2.1 http://enzyme.expasy.org/EC/2.1.2.1 EchoBASE EB0403 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0403 EcoGene EG10408 http://www.ecogene.org/geneInfo.php?eg_id=EG10408 EnsemblBacteria AAC75604 http://www.ensemblgenomes.org/id/AAC75604 EnsemblBacteria AAC75604 http://www.ensemblgenomes.org/id/AAC75604 EnsemblBacteria BAA16459 http://www.ensemblgenomes.org/id/BAA16459 EnsemblBacteria BAA16459 http://www.ensemblgenomes.org/id/BAA16459 EnsemblBacteria BAA16459 http://www.ensemblgenomes.org/id/BAA16459 EnsemblBacteria b2551 http://www.ensemblgenomes.org/id/b2551 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0004372 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004372 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0006546 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006546 GO_process GO:0006565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006565 GO_process GO:0019264 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019264 GO_process GO:0035999 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035999 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.640.10 http://www.cathdb.info/version/latest/superfamily/3.40.640.10 Gene3D 3.90.1150.10 http://www.cathdb.info/version/latest/superfamily/3.90.1150.10 GeneID 947022 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947022 HAMAP MF_00051 http://hamap.expasy.org/unirule/MF_00051 HOGENOM HOG000239404 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000239404&db=HOGENOM6 InParanoid P0A825 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A825 IntAct P0A825 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A825* IntEnz 2.1.2.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.2.1 InterPro IPR001085 http://www.ebi.ac.uk/interpro/entry/IPR001085 InterPro IPR015421 http://www.ebi.ac.uk/interpro/entry/IPR015421 InterPro IPR015422 http://www.ebi.ac.uk/interpro/entry/IPR015422 InterPro IPR015424 http://www.ebi.ac.uk/interpro/entry/IPR015424 InterPro IPR019798 http://www.ebi.ac.uk/interpro/entry/IPR019798 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2535 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2535 KEGG_Gene eco:b2551 http://www.genome.jp/dbget-bin/www_bget?eco:b2551 KEGG_Orthology KO:K00600 http://www.genome.jp/dbget-bin/www_bget?KO:K00600 KEGG_Pathway ko00260 http://www.genome.jp/kegg-bin/show_pathway?ko00260 KEGG_Pathway ko00460 http://www.genome.jp/kegg-bin/show_pathway?ko00460 KEGG_Pathway ko00630 http://www.genome.jp/kegg-bin/show_pathway?ko00630 KEGG_Pathway ko00670 http://www.genome.jp/kegg-bin/show_pathway?ko00670 KEGG_Pathway ko00680 http://www.genome.jp/kegg-bin/show_pathway?ko00680 KEGG_Reaction rn:R00945 http://www.genome.jp/dbget-bin/www_bget?rn:R00945 KEGG_Reaction rn:R09099 http://www.genome.jp/dbget-bin/www_bget?rn:R09099 MINT MINT-7293373 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-7293373 OMA DANNPAV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DANNPAV PANTHER PTHR11680 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11680 PDB 1DFO http://www.ebi.ac.uk/pdbe-srv/view/entry/1DFO PDB 1EQB http://www.ebi.ac.uk/pdbe-srv/view/entry/1EQB PDB 3G8M http://www.ebi.ac.uk/pdbe-srv/view/entry/3G8M PDBsum 1DFO http://www.ebi.ac.uk/pdbsum/1DFO PDBsum 1EQB http://www.ebi.ac.uk/pdbsum/1EQB PDBsum 3G8M http://www.ebi.ac.uk/pdbsum/3G8M PROSITE PS00096 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00096 PSORT swissprot:GLYA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLYA_ECOLI PSORT-B swissprot:GLYA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLYA_ECOLI PSORT2 swissprot:GLYA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLYA_ECOLI Pfam PF00464 http://pfam.xfam.org/family/PF00464 Phobius swissprot:GLYA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLYA_ECOLI PhylomeDB P0A825 http://phylomedb.org/?seqid=P0A825 ProteinModelPortal P0A825 http://www.proteinmodelportal.org/query/uniprot/P0A825 PubMed 10656824 http://www.ncbi.nlm.nih.gov/pubmed/10656824 PubMed 10858298 http://www.ncbi.nlm.nih.gov/pubmed/10858298 PubMed 12624214 http://www.ncbi.nlm.nih.gov/pubmed/12624214 PubMed 12773539 http://www.ncbi.nlm.nih.gov/pubmed/12773539 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17341210 http://www.ncbi.nlm.nih.gov/pubmed/17341210 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 19019081 http://www.ncbi.nlm.nih.gov/pubmed/19019081 PubMed 19883126 http://www.ncbi.nlm.nih.gov/pubmed/19883126 PubMed 2034230 http://www.ncbi.nlm.nih.gov/pubmed/2034230 PubMed 21151122 http://www.ncbi.nlm.nih.gov/pubmed/21151122 PubMed 6190704 http://www.ncbi.nlm.nih.gov/pubmed/6190704 PubMed 6300791 http://www.ncbi.nlm.nih.gov/pubmed/6300791 PubMed 7925461 http://www.ncbi.nlm.nih.gov/pubmed/7925461 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_417046 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417046 RefSeq WP_000919159 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000919159 SMR P0A825 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A825 STRING 511145.b2551 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2551&targetmode=cogs STRING COG0112 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0112&targetmode=cogs SUPFAM SSF53383 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53383 SWISS-2DPAGE P0A825 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A825 UniProtKB GLYA_ECOLI http://www.uniprot.org/uniprot/GLYA_ECOLI UniProtKB-AC P0A825 http://www.uniprot.org/uniprot/P0A825 charge swissprot:GLYA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLYA_ECOLI eggNOG COG0112 http://eggnogapi.embl.de/nog_data/html/tree/COG0112 eggNOG ENOG4105C65 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C65 epestfind swissprot:GLYA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLYA_ECOLI garnier swissprot:GLYA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLYA_ECOLI helixturnhelix swissprot:GLYA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLYA_ECOLI hmoment swissprot:GLYA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLYA_ECOLI iep swissprot:GLYA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLYA_ECOLI inforesidue swissprot:GLYA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLYA_ECOLI octanol swissprot:GLYA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLYA_ECOLI pepcoil swissprot:GLYA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLYA_ECOLI pepdigest swissprot:GLYA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLYA_ECOLI pepinfo swissprot:GLYA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLYA_ECOLI pepnet swissprot:GLYA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLYA_ECOLI pepstats swissprot:GLYA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLYA_ECOLI pepwheel swissprot:GLYA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLYA_ECOLI pepwindow swissprot:GLYA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLYA_ECOLI sigcleave swissprot:GLYA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLYA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259617 378 # CATALYTIC ACTIVITY AMIA_ECOLI Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. # CDD cd02696 MurNAc-LAA # DISRUPTION PHENOTYPE Mutants are growing in chains of 3 to 6 cells. {ECO:0000269|PubMed 11454209}. # EcoGene EG11823 amiA # FUNCTION AMIA_ECOLI Cell-wall hydrolase involved in septum cleavage during cell division. Can also act as powerful autolysin in the presence of murein synthesis inhibitors. {ECO 0000269|PubMed 11454209, ECO 0000269|PubMed 18390656}. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_component GO:0042597 periplasmic space; IDA:EcoliWiki. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_function GO:0008745 N-acetylmuramoyl-L-alanine amidase activity; IDA:EcoCyc. # GO_process GO:0009253 peptidoglycan catabolic process; IEA:InterPro. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 3.40.630.40 -; 2. # IntAct P36548 9 # InterPro IPR002508 MurNAc-LAA_cat # InterPro IPR006311 TAT_signal # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03036 Chromosome # Organism AMIA_ECOLI Escherichia coli (strain K12) # PATRIC 32120255 VBIEscCol129921_2530 # PIR A36964 A36964 # PROSITE PS51318 TAT # PTM AMIA_ECOLI Exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven. Can also be exported by the Sec system. # Pfam PF01520 Amidase_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AMIA_ECOLI N-acetylmuramoyl-L-alanine amidase AmiA # RefSeq NP_416930 NC_000913.3 # RefSeq WP_000102886 NZ_LN832404.1 # SIMILARITY Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family. {ECO 0000305}. # SMART SM00646 Ami_3 # SUBCELLULAR LOCATION AMIA_ECOLI Periplasm {ECO 0000269|PubMed 12787347}. Note=Distributed throughout the periplasm in all cells. # eggNOG COG0860 LUCA # eggNOG ENOG4108KNB Bacteria BLAST swissprot:AMIA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AMIA_ECOLI BioCyc ECOL316407:JW2428-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2428-MONOMER BioCyc EcoCyc:NACMURLALAAMI1-MONOMER http://biocyc.org/getid?id=EcoCyc:NACMURLALAAMI1-MONOMER BioCyc MetaCyc:NACMURLALAAMI1-MONOMER http://biocyc.org/getid?id=MetaCyc:NACMURLALAAMI1-MONOMER COG COG0860 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0860 DIP DIP-9098N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9098N DOI 10.1007/BF00260648 http://dx.doi.org/10.1007/BF00260648 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2001.02499.x http://dx.doi.org/10.1046/j.1365-2958.2001.02499.x DOI 10.1046/j.1365-2958.2003.03511.x http://dx.doi.org/10.1046/j.1365-2958.2003.03511.x DOI 10.1074/jbc.M610507200 http://dx.doi.org/10.1074/jbc.M610507200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00207-08 http://dx.doi.org/10.1128/JB.00207-08 EC_number EC:3.5.1.28 http://www.genome.jp/dbget-bin/www_bget?EC:3.5.1.28 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X63986 http://www.ebi.ac.uk/ena/data/view/X63986 EMBL X75413 http://www.ebi.ac.uk/ena/data/view/X75413 ENZYME 3.5.1.28 http://enzyme.expasy.org/EC/3.5.1.28 EchoBASE EB1770 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1770 EcoGene EG11823 http://www.ecogene.org/geneInfo.php?eg_id=EG11823 EnsemblBacteria AAC75488 http://www.ensemblgenomes.org/id/AAC75488 EnsemblBacteria AAC75488 http://www.ensemblgenomes.org/id/AAC75488 EnsemblBacteria BAA16318 http://www.ensemblgenomes.org/id/BAA16318 EnsemblBacteria BAA16318 http://www.ensemblgenomes.org/id/BAA16318 EnsemblBacteria BAA16318 http://www.ensemblgenomes.org/id/BAA16318 EnsemblBacteria b2435 http://www.ensemblgenomes.org/id/b2435 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0008745 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008745 GO_process GO:0009253 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009253 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 3.40.630.40 http://www.cathdb.info/version/latest/superfamily/3.40.630.40 GeneID 946916 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946916 HOGENOM HOG000263827 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000263827&db=HOGENOM6 InParanoid P36548 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P36548 IntAct P36548 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P36548* IntEnz 3.5.1.28 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.1.28 InterPro IPR002508 http://www.ebi.ac.uk/interpro/entry/IPR002508 InterPro IPR006311 http://www.ebi.ac.uk/interpro/entry/IPR006311 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene ecj:JW2428 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2428 KEGG_Gene eco:b2435 http://www.genome.jp/dbget-bin/www_bget?eco:b2435 KEGG_Orthology KO:K01448 http://www.genome.jp/dbget-bin/www_bget?KO:K01448 KEGG_Reaction rn:R04112 http://www.genome.jp/dbget-bin/www_bget?rn:R04112 OMA QTDTINN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QTDTINN PROSITE PS51318 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51318 PSORT swissprot:AMIA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AMIA_ECOLI PSORT-B swissprot:AMIA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AMIA_ECOLI PSORT2 swissprot:AMIA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AMIA_ECOLI Pfam PF01520 http://pfam.xfam.org/family/PF01520 Phobius swissprot:AMIA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AMIA_ECOLI PhylomeDB P36548 http://phylomedb.org/?seqid=P36548 ProteinModelPortal P36548 http://www.proteinmodelportal.org/query/uniprot/P36548 PubMed 11454209 http://www.ncbi.nlm.nih.gov/pubmed/11454209 PubMed 12787347 http://www.ncbi.nlm.nih.gov/pubmed/12787347 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17218314 http://www.ncbi.nlm.nih.gov/pubmed/17218314 PubMed 18390656 http://www.ncbi.nlm.nih.gov/pubmed/18390656 PubMed 1903834 http://www.ncbi.nlm.nih.gov/pubmed/1903834 PubMed 8300522 http://www.ncbi.nlm.nih.gov/pubmed/8300522 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416930 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416930 RefSeq WP_000102886 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000102886 SMART SM00646 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00646 SMR P36548 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P36548 STRING 511145.b2435 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2435&targetmode=cogs STRING COG0860 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0860&targetmode=cogs UniProtKB AMIA_ECOLI http://www.uniprot.org/uniprot/AMIA_ECOLI UniProtKB-AC P36548 http://www.uniprot.org/uniprot/P36548 charge swissprot:AMIA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AMIA_ECOLI eggNOG COG0860 http://eggnogapi.embl.de/nog_data/html/tree/COG0860 eggNOG ENOG4108KNB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108KNB epestfind swissprot:AMIA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AMIA_ECOLI garnier swissprot:AMIA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AMIA_ECOLI helixturnhelix swissprot:AMIA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AMIA_ECOLI hmoment swissprot:AMIA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AMIA_ECOLI iep swissprot:AMIA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AMIA_ECOLI inforesidue swissprot:AMIA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AMIA_ECOLI octanol swissprot:AMIA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AMIA_ECOLI pepcoil swissprot:AMIA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AMIA_ECOLI pepdigest swissprot:AMIA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AMIA_ECOLI pepinfo swissprot:AMIA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AMIA_ECOLI pepnet swissprot:AMIA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AMIA_ECOLI pepstats swissprot:AMIA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AMIA_ECOLI pepwheel swissprot:AMIA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AMIA_ECOLI pepwindow swissprot:AMIA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AMIA_ECOLI sigcleave swissprot:AMIA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AMIA_ECOLI ## Database ID URL or Descriptions # AltName Small protein B {ECO:0000255|HAMAP-Rule MF_00023} # BioGrid 4260987 26 # CDD cd09294 SmpB # DISRUPTION PHENOTYPE SSRP_ECOLI No visible phenotype during growth on solid medium at 16-42 degrees Celsius on rich or minimal media, no peptide-tagging of proteins translated from mRNA lacking a stop codon by tmRNA, i.e. no trans-translation (PubMed 10393194, PubMed 11917023, PubMed 15069072). 4-8 fold increased susceptibility to a number of antibiotics (norfloxacin, gentamicin, trimethoprim, tetracycline and streptomycin but not ampicillin), very significantly reduced production of persister cells (PubMed 23812681). A number of bacteriophage development defects (PubMed 10393194). {ECO 0000269|PubMed 10393194, ECO 0000269|PubMed 11917023, ECO 0000269|PubMed 15069072, ECO 0000269|PubMed 23812681}. # EcoGene EG11782 smpB # FUNCTION SSRP_ECOLI Required for rescue of stalled ribosomes mediated by trans-translation. Binds to tmRNA RNA (also known as SsrA or 10Sa RNA, 363 nucleotides in this organism), required for stable binding of tmRNA to ribosomes (PubMed 10393194, PubMed 11904185, PubMed 11917023). tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB (Probable). tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. Able to recruit charged tmRNA to ribosomes (PubMed 15069072). Does not play a role in transcription, processing or Ala-aminoacylation of tmRNA (PubMed 10393194). Other studies have shown it stimulates aminoacylation of tmRNA (PubMed 11917023, PubMed 11904185). May protect tmRNA from degradation (PubMed 11917023). Binds to tmRNA that cannot be aminoacylated (tmRNA G3A), does not bind to tmRNA mutations near the tRNA-like termini (tmRNA G19C, A334U); other tmRNA mutations that block trans-translation still bind SmpB (PubMed 11917023). With tmRNA may play a role in bacterial persistence (PubMed 23812681). During trans-translation Ala-aminoacylated transfer-messenger RNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA, the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans- translation. {ECO 0000269|PubMed 10393194, ECO 0000269|PubMed 11904185, ECO 0000269|PubMed 11917023, ECO 0000269|PubMed 15069072, ECO 0000269|PubMed 15699355, ECO 0000269|PubMed 20348441, ECO 0000269|PubMed 20940705, ECO 0000269|PubMed 22622583, ECO 0000269|PubMed 23812681, ECO 0000305|PubMed 20940705}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003723 RNA binding; IDA:EcoCyc. # GO_process GO:0070929 trans-translation; IEA:UniProtKB-HAMAP. # GO_process GO:0070930 trans-translation-dependent protein tagging; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0009058 biosynthetic process # Gene3D 2.40.280.10 -; 1. # HAMAP MF_00023 SmpB # IntAct P0A832 32 # InterPro IPR000037 SsrA-bd_prot # InterPro IPR020081 SsrA-bd_prot_CS # InterPro IPR023620 SmpB # MISCELLANEOUS SSRP_ECOLI Although the Fu et al., electron microscopy paper indicates this protein came from E.coli its sequence maps to T.thermophilus (PubMed 20940705). The same situation holds for Ramrath et al., (PubMed 22622583). {ECO 0000305|PubMed 20940705, ECO 0000305|PubMed 22622583}. # Organism SSRP_ECOLI Escherichia coli (strain K12) # PATRIC 32120639 VBIEscCol129921_2718 # PIR JS0701 JS0701 # PROSITE PS01317 SSRP # Pfam PF01668 SmpB # ProDom PD004488 SmpB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SsrA-binding protein {ECO:0000255|HAMAP-Rule MF_00023} # RefSeq NP_417110 NC_000913.3 # RefSeq WP_000162574 NZ_LN832404.1 # SIMILARITY Belongs to the SmpB family. {ECO:0000255|HAMAP- Rule MF_00023}. # SUBCELLULAR LOCATION SSRP_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00023, ECO 0000269|PubMed 11917023, ECO 0000269|PubMed 15069072}. Note=The tmRNA-SmpB complex associates with stalled ribosomes (PubMed 10393194, PubMed 11917023, PubMed 15699355, PubMed 20940705, PubMed 22622583). SmpB associates with ribosomes even in the absence of tmRNA (PubMed 15069072). {ECO 0000255|HAMAP-Rule MF_00023, ECO 0000269|PubMed 10393194, ECO 0000269|PubMed 11917023, ECO 0000269|PubMed 15069072, ECO 0000269|PubMed 15699355, ECO 0000269|PubMed 20940705, ECO 0000269|PubMed 22622583}. # SUBUNIT SSRP_ECOLI Binds tmRNA (PubMed 10393194, PubMed 11904185, PubMed 11917023, PubMed 15699355, PubMed 20940705, PubMed 22622583). The SmpB-tmRNA complex binds to stalled ribosomes (PubMed 10393194, PubMed 11917023, PubMed 15699355, PubMed 20940705, PubMed 22622583). {ECO 0000269|PubMed 10393194, ECO 0000269|PubMed 11904185, ECO 0000269|PubMed 11917023, ECO 0000269|PubMed 15069072, ECO 0000269|PubMed 15699355, ECO 0000269|PubMed 20940705, ECO 0000269|PubMed 22622583}. # SUPFAM SSF74982 SSF74982 # TIGRFAMs TIGR00086 smpB # eggNOG COG0691 LUCA # eggNOG ENOG4108UH4 Bacteria BLAST swissprot:SSRP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SSRP_ECOLI BioCyc ECOL316407:JW2601-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2601-MONOMER BioCyc EcoCyc:EG11782-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11782-MONOMER COG COG0691 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0691 DIP DIP-47871N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47871N DOI 10.1016/S0014-5793(02)02333-5 http://dx.doi.org/10.1016/S0014-5793(02)02333-5 DOI 10.1038/emboj.2010.255 http://dx.doi.org/10.1038/emboj.2010.255 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature11006 http://dx.doi.org/10.1038/nature11006 DOI 10.1073/pnas.0409694102 http://dx.doi.org/10.1073/pnas.0409694102 DOI 10.1073/pnas.91.20.9223 http://dx.doi.org/10.1073/pnas.91.20.9223 DOI 10.1074/jbc.M314086200 http://dx.doi.org/10.1074/jbc.M314086200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/emboj/18.13.3793 http://dx.doi.org/10.1093/emboj/18.13.3793 DOI 10.1093/jac/dkt231 http://dx.doi.org/10.1093/jac/dkt231 DOI 10.1093/nar/30.7.1620 http://dx.doi.org/10.1093/nar/30.7.1620 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1261/rna.1916610 http://dx.doi.org/10.1261/rna.1916610 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D12501 http://www.ebi.ac.uk/ena/data/view/D12501 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36840 http://www.ebi.ac.uk/ena/data/view/U36840 EchoBASE EB1730 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1730 EcoGene EG11782 http://www.ecogene.org/geneInfo.php?eg_id=EG11782 EnsemblBacteria AAC75669 http://www.ensemblgenomes.org/id/AAC75669 EnsemblBacteria AAC75669 http://www.ensemblgenomes.org/id/AAC75669 EnsemblBacteria BAA16505 http://www.ensemblgenomes.org/id/BAA16505 EnsemblBacteria BAA16505 http://www.ensemblgenomes.org/id/BAA16505 EnsemblBacteria BAA16505 http://www.ensemblgenomes.org/id/BAA16505 EnsemblBacteria b2620 http://www.ensemblgenomes.org/id/b2620 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_process GO:0070929 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070929 GO_process GO:0070930 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070930 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 2.40.280.10 http://www.cathdb.info/version/latest/superfamily/2.40.280.10 GeneID 947296 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947296 HAMAP MF_00023 http://hamap.expasy.org/unirule/MF_00023 HOGENOM HOG000009628 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009628&db=HOGENOM6 InParanoid P0A832 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A832 IntAct P0A832 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A832* InterPro IPR000037 http://www.ebi.ac.uk/interpro/entry/IPR000037 InterPro IPR020081 http://www.ebi.ac.uk/interpro/entry/IPR020081 InterPro IPR023620 http://www.ebi.ac.uk/interpro/entry/IPR023620 KEGG_Gene ecj:JW2601 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2601 KEGG_Gene eco:b2620 http://www.genome.jp/dbget-bin/www_bget?eco:b2620 KEGG_Orthology KO:K03664 http://www.genome.jp/dbget-bin/www_bget?KO:K03664 MINT MINT-1229819 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1229819 OMA QNKKASH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QNKKASH PROSITE PS01317 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01317 PSORT swissprot:SSRP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SSRP_ECOLI PSORT-B swissprot:SSRP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SSRP_ECOLI PSORT2 swissprot:SSRP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SSRP_ECOLI Pfam PF01668 http://pfam.xfam.org/family/PF01668 Phobius swissprot:SSRP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SSRP_ECOLI PhylomeDB P0A832 http://phylomedb.org/?seqid=P0A832 ProteinModelPortal P0A832 http://www.proteinmodelportal.org/query/uniprot/P0A832 PubMed 10393194 http://www.ncbi.nlm.nih.gov/pubmed/10393194 PubMed 11904185 http://www.ncbi.nlm.nih.gov/pubmed/11904185 PubMed 11917023 http://www.ncbi.nlm.nih.gov/pubmed/11917023 PubMed 15069072 http://www.ncbi.nlm.nih.gov/pubmed/15069072 PubMed 15699355 http://www.ncbi.nlm.nih.gov/pubmed/15699355 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20348441 http://www.ncbi.nlm.nih.gov/pubmed/20348441 PubMed 2045357 http://www.ncbi.nlm.nih.gov/pubmed/2045357 PubMed 20940705 http://www.ncbi.nlm.nih.gov/pubmed/20940705 PubMed 22622583 http://www.ncbi.nlm.nih.gov/pubmed/22622583 PubMed 23812681 http://www.ncbi.nlm.nih.gov/pubmed/23812681 PubMed 7524073 http://www.ncbi.nlm.nih.gov/pubmed/7524073 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417110 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417110 RefSeq WP_000162574 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000162574 STRING 511145.b2620 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2620&targetmode=cogs STRING COG0691 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0691&targetmode=cogs SUPFAM SSF74982 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF74982 TIGRFAMs TIGR00086 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00086 UniProtKB SSRP_ECOLI http://www.uniprot.org/uniprot/SSRP_ECOLI UniProtKB-AC P0A832 http://www.uniprot.org/uniprot/P0A832 charge swissprot:SSRP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SSRP_ECOLI eggNOG COG0691 http://eggnogapi.embl.de/nog_data/html/tree/COG0691 eggNOG ENOG4108UH4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UH4 epestfind swissprot:SSRP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SSRP_ECOLI garnier swissprot:SSRP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SSRP_ECOLI helixturnhelix swissprot:SSRP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SSRP_ECOLI hmoment swissprot:SSRP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SSRP_ECOLI iep swissprot:SSRP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SSRP_ECOLI inforesidue swissprot:SSRP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SSRP_ECOLI octanol swissprot:SSRP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SSRP_ECOLI pepcoil swissprot:SSRP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SSRP_ECOLI pepdigest swissprot:SSRP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SSRP_ECOLI pepinfo swissprot:SSRP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SSRP_ECOLI pepnet swissprot:SSRP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SSRP_ECOLI pepstats swissprot:SSRP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SSRP_ECOLI pepwheel swissprot:SSRP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SSRP_ECOLI pepwindow swissprot:SSRP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SSRP_ECOLI sigcleave swissprot:SSRP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SSRP_ECOLI ## Database ID URL or Descriptions # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG13380 yeeL # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0008713 ADP-heptose-lipopolysaccharide heptosyltransferase activity; IBA:GO_Central. # GO_process GO:0009244 lipopolysaccharide core region biosynthetic process; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # IntAct P76349 2 # InterPro IPR002201 Glyco_trans_9 # Organism YEEL_ECOLI Escherichia coli (strain K12) # Pfam PF01075 Glyco_transf_9 # Proteomes UP000000625 Chromosome # RecName YEEL_ECOLI Putative uncharacterized protein YeeL # SEQUENCE CAUTION Sequence=U00096; Type=Erroneous termination; Positions=235; Note=Translated as Gln.; Evidence={ECO 0000305}; BLAST swissprot:YEEL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEEL_ECOLI BioCyc EcoCyc:G7065-MONOMER http://biocyc.org/getid?id=EcoCyc:G7065-MONOMER BioCyc EcoCyc:G7066-MONOMER http://biocyc.org/getid?id=EcoCyc:G7066-MONOMER DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG13380 http://www.ecogene.org/geneInfo.php?eg_id=EG13380 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008713 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008713 GO_process GO:0009244 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009244 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 HOGENOM HOG000121653 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000121653&db=HOGENOM6 IntAct P76349 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76349* InterPro IPR002201 http://www.ebi.ac.uk/interpro/entry/IPR002201 PSORT swissprot:YEEL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEEL_ECOLI PSORT-B swissprot:YEEL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEEL_ECOLI PSORT2 swissprot:YEEL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEEL_ECOLI Pfam PF01075 http://pfam.xfam.org/family/PF01075 Phobius swissprot:YEEL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEEL_ECOLI ProteinModelPortal P76349 http://www.proteinmodelportal.org/query/uniprot/P76349 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 UniProtKB YEEL_ECOLI http://www.uniprot.org/uniprot/YEEL_ECOLI UniProtKB-AC P76349 http://www.uniprot.org/uniprot/P76349 charge swissprot:YEEL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEEL_ECOLI epestfind swissprot:YEEL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEEL_ECOLI garnier swissprot:YEEL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEEL_ECOLI helixturnhelix swissprot:YEEL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEEL_ECOLI hmoment swissprot:YEEL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEEL_ECOLI iep swissprot:YEEL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEEL_ECOLI inforesidue swissprot:YEEL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEEL_ECOLI octanol swissprot:YEEL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEEL_ECOLI pepcoil swissprot:YEEL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEEL_ECOLI pepdigest swissprot:YEEL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEEL_ECOLI pepinfo swissprot:YEEL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEEL_ECOLI pepnet swissprot:YEEL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEEL_ECOLI pepstats swissprot:YEEL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEEL_ECOLI pepwheel swissprot:YEEL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEEL_ECOLI pepwindow swissprot:YEEL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEEL_ECOLI sigcleave swissprot:YEEL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEEL_ECOLI ## Database ID URL or Descriptions # BioGrid 4261210 8 # EcoGene EG10636 nagC # FUNCTION NAGC_ECOLI Acts as a repressor of the nagEBACD operon and acts both as an activator and a repressor for the transcription of the glmSU operon. {ECO 0000269|PubMed 7545108}. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0005975 carbohydrate metabolic process; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IMP:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # INDUCTION NAGC_ECOLI By N-acetylglucosamine. # IntAct P0AF20 9 # InterPro IPR000600 ROK # InterPro IPR000835 HTH_MarR-typ # InterPro IPR011991 WHTH_DNA-bd_dom # KEGG_Brite ko03000 Transcription factors # Organism NAGC_ECOLI Escherichia coli (strain K12) # PATRIC 32116537 VBIEscCol129921_0701 # PIR C64802 C64802 # PROSITE PS01125 ROK # Pfam PF00480 ROK # Pfam PF01047 MarR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NAGC_ECOLI N-acetylglucosamine repressor # RefSeq NP_415202 NC_000913.3 # RefSeq WP_000187594 NZ_LN832404.1 # SIMILARITY Belongs to the ROK (NagC/XylR) family. {ECO 0000305}. # SUPFAM SSF46785 SSF46785 # eggNOG COG1940 LUCA # eggNOG ENOG4105E2R Bacteria BLAST swissprot:NAGC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NAGC_ECOLI BioCyc ECOL316407:JW0662-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0662-MONOMER BioCyc EcoCyc:PD00266 http://biocyc.org/getid?id=EcoCyc:PD00266 COG COG1940 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1940 DIP DIP-35984N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35984N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1989.tb00197.x http://dx.doi.org/10.1111/j.1365-2958.1989.tb00197.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AF052007 http://www.ebi.ac.uk/ena/data/view/AF052007 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X14135 http://www.ebi.ac.uk/ena/data/view/X14135 EchoBASE EB0630 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0630 EcoGene EG10636 http://www.ecogene.org/geneInfo.php?eg_id=EG10636 EnsemblBacteria AAC73770 http://www.ensemblgenomes.org/id/AAC73770 EnsemblBacteria AAC73770 http://www.ensemblgenomes.org/id/AAC73770 EnsemblBacteria BAA35319 http://www.ensemblgenomes.org/id/BAA35319 EnsemblBacteria BAA35319 http://www.ensemblgenomes.org/id/BAA35319 EnsemblBacteria BAA35319 http://www.ensemblgenomes.org/id/BAA35319 EnsemblBacteria b0676 http://www.ensemblgenomes.org/id/b0676 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 945285 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945285 HOGENOM HOG000275182 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275182&db=HOGENOM6 InParanoid P0AF20 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AF20 IntAct P0AF20 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AF20* InterPro IPR000600 http://www.ebi.ac.uk/interpro/entry/IPR000600 InterPro IPR000835 http://www.ebi.ac.uk/interpro/entry/IPR000835 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW0662 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0662 KEGG_Gene eco:b0676 http://www.genome.jp/dbget-bin/www_bget?eco:b0676 KEGG_Orthology KO:K02565 http://www.genome.jp/dbget-bin/www_bget?KO:K02565 OMA HQRRIRE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HQRRIRE PROSITE PS01125 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01125 PSORT swissprot:NAGC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NAGC_ECOLI PSORT-B swissprot:NAGC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NAGC_ECOLI PSORT2 swissprot:NAGC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NAGC_ECOLI Pfam PF00480 http://pfam.xfam.org/family/PF00480 Pfam PF01047 http://pfam.xfam.org/family/PF01047 Phobius swissprot:NAGC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NAGC_ECOLI PhylomeDB P0AF20 http://phylomedb.org/?seqid=P0AF20 ProteinModelPortal P0AF20 http://www.proteinmodelportal.org/query/uniprot/P0AF20 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2190615 http://www.ncbi.nlm.nih.gov/pubmed/2190615 PubMed 2668691 http://www.ncbi.nlm.nih.gov/pubmed/2668691 PubMed 7545108 http://www.ncbi.nlm.nih.gov/pubmed/7545108 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415202 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415202 RefSeq WP_000187594 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000187594 SMR P0AF20 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AF20 STRING 511145.b0676 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0676&targetmode=cogs STRING COG1940 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1940&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB NAGC_ECOLI http://www.uniprot.org/uniprot/NAGC_ECOLI UniProtKB-AC P0AF20 http://www.uniprot.org/uniprot/P0AF20 charge swissprot:NAGC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NAGC_ECOLI eggNOG COG1940 http://eggnogapi.embl.de/nog_data/html/tree/COG1940 eggNOG ENOG4105E2R http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E2R epestfind swissprot:NAGC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NAGC_ECOLI garnier swissprot:NAGC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NAGC_ECOLI helixturnhelix swissprot:NAGC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NAGC_ECOLI hmoment swissprot:NAGC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NAGC_ECOLI iep swissprot:NAGC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NAGC_ECOLI inforesidue swissprot:NAGC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NAGC_ECOLI octanol swissprot:NAGC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NAGC_ECOLI pepcoil swissprot:NAGC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NAGC_ECOLI pepdigest swissprot:NAGC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NAGC_ECOLI pepinfo swissprot:NAGC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NAGC_ECOLI pepnet swissprot:NAGC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NAGC_ECOLI pepstats swissprot:NAGC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NAGC_ECOLI pepwheel swissprot:NAGC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NAGC_ECOLI pepwindow swissprot:NAGC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NAGC_ECOLI sigcleave swissprot:NAGC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NAGC_ECOLI ## Database ID URL or Descriptions # AltName HEMH_ECOLI Heme synthase # AltName HEMH_ECOLI Protoheme ferro-lyase # CATALYTIC ACTIVITY HEMH_ECOLI Protoheme + 2 H(+) = protoporphyrin + Fe(2+). # CDD cd00419 Ferrochelatase_C # CDD cd03411 Ferrochelatase_N # DISRUPTION PHENOTYPE Cells are sensitive to visible light (which is lethal). {ECO:0000269|PubMed 2051480}. # EcoGene EG10431 hemH # FUNCTION HEMH_ECOLI Catalyzes the ferrous insertion into protoporphyrin IX. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0004325 ferrochelatase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006783 heme biosynthetic process; IDA:EcoliWiki. # GO_process GO:0009416 response to light stimulus; IMP:EcoliWiki. # GO_process GO:0046501 protoporphyrinogen IX metabolic process; IMP:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0051186 cofactor metabolic process # HAMAP MF_00323 Ferrochelatase # IntAct P23871 9 # InterPro IPR001015 Ferrochelatase # InterPro IPR019772 Ferrochelatase_AS # InterPro IPR033644 Ferrochelatase_C # InterPro IPR033659 Ferrochelatase_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00860 Porphyrin and chlorophyll metabolism # Organism HEMH_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11108 PTHR11108 # PATHWAY Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX step 1/1. # PATRIC 32116107 VBIEscCol129921_0495 # PIR B64778 B64778 # PROSITE PS00534 FERROCHELATASE # Pfam PF00762 Ferrochelatase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HEMH_ECOLI Ferrochelatase # RefSeq NP_415008 NC_000913.3 # RefSeq WP_001250103 NZ_LN832404.1 # SIMILARITY Belongs to the ferrochelatase family. {ECO 0000305}. # SUBCELLULAR LOCATION HEMH_ECOLI Cytoplasm. # SUBUNIT HEMH_ECOLI Monomer. # TIGRFAMs TIGR00109 hemH # UniPathway UPA00252 UER00325 # eggNOG COG0276 LUCA # eggNOG ENOG4105CFX Bacteria BLAST swissprot:HEMH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HEMH_ECOLI BioCyc ECOL316407:JW0464-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0464-MONOMER BioCyc EcoCyc:PROTOHEME-FERROCHELAT-MONOMER http://biocyc.org/getid?id=EcoCyc:PROTOHEME-FERROCHELAT-MONOMER BioCyc MetaCyc:PROTOHEME-FERROCHELAT-MONOMER http://biocyc.org/getid?id=MetaCyc:PROTOHEME-FERROCHELAT-MONOMER COG COG0276 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0276 DOI 10.1016/0022-2836(91)90180-E http://dx.doi.org/10.1016/0022-2836(91)90180-E DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.99.1.1 http://www.genome.jp/dbget-bin/www_bget?EC:4.99.1.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D90259 http://www.ebi.ac.uk/ena/data/view/D90259 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 ENZYME 4.99.1.1 http://enzyme.expasy.org/EC/4.99.1.1 EchoBASE EB0426 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0426 EcoGene EG10431 http://www.ecogene.org/geneInfo.php?eg_id=EG10431 EnsemblBacteria AAC73577 http://www.ensemblgenomes.org/id/AAC73577 EnsemblBacteria AAC73577 http://www.ensemblgenomes.org/id/AAC73577 EnsemblBacteria BAE76254 http://www.ensemblgenomes.org/id/BAE76254 EnsemblBacteria BAE76254 http://www.ensemblgenomes.org/id/BAE76254 EnsemblBacteria BAE76254 http://www.ensemblgenomes.org/id/BAE76254 EnsemblBacteria b0475 http://www.ensemblgenomes.org/id/b0475 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004325 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004325 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006783 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006783 GO_process GO:0009416 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009416 GO_process GO:0046501 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046501 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GeneID 947532 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947532 HAMAP MF_00323 http://hamap.expasy.org/unirule/MF_00323 HOGENOM HOG000060730 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000060730&db=HOGENOM6 InParanoid P23871 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23871 IntAct P23871 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P23871* IntEnz 4.99.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.99.1.1 InterPro IPR001015 http://www.ebi.ac.uk/interpro/entry/IPR001015 InterPro IPR019772 http://www.ebi.ac.uk/interpro/entry/IPR019772 InterPro IPR033644 http://www.ebi.ac.uk/interpro/entry/IPR033644 InterPro IPR033659 http://www.ebi.ac.uk/interpro/entry/IPR033659 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0464 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0464 KEGG_Gene eco:b0475 http://www.genome.jp/dbget-bin/www_bget?eco:b0475 KEGG_Orthology KO:K01772 http://www.genome.jp/dbget-bin/www_bget?KO:K01772 KEGG_Pathway ko00860 http://www.genome.jp/kegg-bin/show_pathway?ko00860 KEGG_Reaction rn:R00310 http://www.genome.jp/dbget-bin/www_bget?rn:R00310 OMA WEEGSPL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WEEGSPL PANTHER PTHR11108 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11108 PROSITE PS00534 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00534 PSORT swissprot:HEMH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HEMH_ECOLI PSORT-B swissprot:HEMH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HEMH_ECOLI PSORT2 swissprot:HEMH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HEMH_ECOLI Pfam PF00762 http://pfam.xfam.org/family/PF00762 Phobius swissprot:HEMH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HEMH_ECOLI PhylomeDB P23871 http://phylomedb.org/?seqid=P23871 ProteinModelPortal P23871 http://www.proteinmodelportal.org/query/uniprot/P23871 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2051480 http://www.ncbi.nlm.nih.gov/pubmed/2051480 PubMed 8056770 http://www.ncbi.nlm.nih.gov/pubmed/8056770 PubMed 8458858 http://www.ncbi.nlm.nih.gov/pubmed/8458858 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415008 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415008 RefSeq WP_001250103 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001250103 SMR P23871 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P23871 STRING 511145.b0475 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0475&targetmode=cogs STRING COG0276 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0276&targetmode=cogs TIGRFAMs TIGR00109 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00109 UniProtKB HEMH_ECOLI http://www.uniprot.org/uniprot/HEMH_ECOLI UniProtKB-AC P23871 http://www.uniprot.org/uniprot/P23871 charge swissprot:HEMH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HEMH_ECOLI eggNOG COG0276 http://eggnogapi.embl.de/nog_data/html/tree/COG0276 eggNOG ENOG4105CFX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CFX epestfind swissprot:HEMH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HEMH_ECOLI garnier swissprot:HEMH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HEMH_ECOLI helixturnhelix swissprot:HEMH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HEMH_ECOLI hmoment swissprot:HEMH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HEMH_ECOLI iep swissprot:HEMH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HEMH_ECOLI inforesidue swissprot:HEMH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HEMH_ECOLI octanol swissprot:HEMH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HEMH_ECOLI pepcoil swissprot:HEMH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HEMH_ECOLI pepdigest swissprot:HEMH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HEMH_ECOLI pepinfo swissprot:HEMH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HEMH_ECOLI pepnet swissprot:HEMH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HEMH_ECOLI pepstats swissprot:HEMH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HEMH_ECOLI pepwheel swissprot:HEMH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HEMH_ECOLI pepwindow swissprot:HEMH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HEMH_ECOLI sigcleave swissprot:HEMH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HEMH_ECOLI ## Database ID URL or Descriptions # BioGrid 4261567 13 # EcoGene EG13629 ybcM # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0000987 core promoter proximal region sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IBA:GO_Central. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IBA:GO_Central. # GO_process GO:0006974 cellular response to DNA damage stimulus; IMP:EcoCyc. # GO_process GO:0046677 response to antibiotic; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.60 -; 1. # IntAct P77634 11 # InterPro IPR009057 Homeodomain-like # InterPro IPR018060 HTH_AraC # MISCELLANEOUS YBCM_ECOLI Encoded by the cryptic lambdoid prophage DLP12. # Organism YBCM_ECOLI Escherichia coli (strain K12) # PATRIC 32116256 VBIEscCol129921_0568 # PIR H64786 H64786 # PROSITE PS01124 HTH_ARAC_FAMILY_2 # Pfam PF12833 HTH_18 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBCM_ECOLI Uncharacterized HTH-type transcriptional regulator YbcM # RefSeq NP_415078 NC_000913.3 # RefSeq WP_000881075 NZ_LN832404.1 # SIMILARITY Contains 1 HTH araC/xylS-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00593}. # SMART SM00342 HTH_ARAC # SUPFAM SSF46689 SSF46689 # eggNOG ENOG4108UQN Bacteria # eggNOG ENOG4111KTA LUCA BLAST swissprot:YBCM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBCM_ECOLI BioCyc ECOL316407:JW0534-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0534-MONOMER BioCyc EcoCyc:G6302-MONOMER http://biocyc.org/getid?id=EcoCyc:G6302-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB3394 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3394 EcoGene EG13629 http://www.ecogene.org/geneInfo.php?eg_id=EG13629 EnsemblBacteria AAC73647 http://www.ensemblgenomes.org/id/AAC73647 EnsemblBacteria AAC73647 http://www.ensemblgenomes.org/id/AAC73647 EnsemblBacteria BAE76321 http://www.ensemblgenomes.org/id/BAE76321 EnsemblBacteria BAE76321 http://www.ensemblgenomes.org/id/BAE76321 EnsemblBacteria BAE76321 http://www.ensemblgenomes.org/id/BAE76321 EnsemblBacteria b0546 http://www.ensemblgenomes.org/id/b0546 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000987 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000987 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 GeneID 945163 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945163 HOGENOM HOG000281126 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000281126&db=HOGENOM6 InParanoid P77634 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77634 IntAct P77634 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77634* InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR018060 http://www.ebi.ac.uk/interpro/entry/IPR018060 KEGG_Gene ecj:JW0534 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0534 KEGG_Gene eco:b0546 http://www.genome.jp/dbget-bin/www_bget?eco:b0546 OMA VTTRRLC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VTTRRLC PROSITE PS01124 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01124 PSORT swissprot:YBCM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBCM_ECOLI PSORT-B swissprot:YBCM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBCM_ECOLI PSORT2 swissprot:YBCM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBCM_ECOLI Pfam PF12833 http://pfam.xfam.org/family/PF12833 Phobius swissprot:YBCM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBCM_ECOLI PhylomeDB P77634 http://phylomedb.org/?seqid=P77634 ProteinModelPortal P77634 http://www.proteinmodelportal.org/query/uniprot/P77634 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415078 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415078 RefSeq WP_000881075 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000881075 SMART SM00342 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00342 SMR P77634 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77634 STRING 511145.b0546 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0546&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 UniProtKB YBCM_ECOLI http://www.uniprot.org/uniprot/YBCM_ECOLI UniProtKB-AC P77634 http://www.uniprot.org/uniprot/P77634 charge swissprot:YBCM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBCM_ECOLI eggNOG ENOG4108UQN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UQN eggNOG ENOG4111KTA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111KTA epestfind swissprot:YBCM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBCM_ECOLI garnier swissprot:YBCM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBCM_ECOLI helixturnhelix swissprot:YBCM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBCM_ECOLI hmoment swissprot:YBCM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBCM_ECOLI iep swissprot:YBCM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBCM_ECOLI inforesidue swissprot:YBCM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBCM_ECOLI octanol swissprot:YBCM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBCM_ECOLI pepcoil swissprot:YBCM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBCM_ECOLI pepdigest swissprot:YBCM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBCM_ECOLI pepinfo swissprot:YBCM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBCM_ECOLI pepnet swissprot:YBCM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBCM_ECOLI pepstats swissprot:YBCM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBCM_ECOLI pepwheel swissprot:YBCM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBCM_ECOLI pepwindow swissprot:YBCM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBCM_ECOLI sigcleave swissprot:YBCM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBCM_ECOLI ## Database ID URL or Descriptions # BioGrid 4262904 7 # EcoGene EG13784 yddM # GO_function GO:0043565 sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.260.40 -; 1. # InterPro IPR001387 Cro/C1-type_HTH # InterPro IPR010982 Lambda_DNA-bd_dom # InterPro IPR013430 Toxin_antidote_HigA # Organism YDDM_ECOLI Escherichia coli (strain K12) # PATRIC 32118248 VBIEscCol129921_1544 # PIR H64900 H64900 # PROSITE PS50943 HTH_CROC1 # Pfam PF01381 HTH_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDDM_ECOLI Uncharacterized HTH-type transcriptional regulator YddM # RefSeq NP_415994 NC_000913.3 # RefSeq WP_000781370 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAE76451.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the VapA/VapI family. {ECO 0000305}. # SIMILARITY Contains 1 HTH cro/C1-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00257}. # SMART SM00530 HTH_XRE # SUPFAM SSF47413 SSF47413 # TIGRFAMs TIGR02607 antidote_HigA # eggNOG COG3093 LUCA # eggNOG ENOG41084S7 Bacteria BLAST swissprot:YDDM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDDM_ECOLI BioCyc ECOL316407:JW5908-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5908-MONOMER BioCyc EcoCyc:G6774-MONOMER http://biocyc.org/getid?id=EcoCyc:G6774-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3546 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3546 EcoGene EG13784 http://www.ecogene.org/geneInfo.php?eg_id=EG13784 EnsemblBacteria AAD13441 http://www.ensemblgenomes.org/id/AAD13441 EnsemblBacteria AAD13441 http://www.ensemblgenomes.org/id/AAD13441 EnsemblBacteria BAE76451 http://www.ensemblgenomes.org/id/BAE76451 EnsemblBacteria BAE76451 http://www.ensemblgenomes.org/id/BAE76451 EnsemblBacteria BAE76451 http://www.ensemblgenomes.org/id/BAE76451 EnsemblBacteria b1477 http://www.ensemblgenomes.org/id/b1477 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.260.40 http://www.cathdb.info/version/latest/superfamily/1.10.260.40 GeneID 946040 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946040 HOGENOM HOG000265974 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000265974&db=HOGENOM6 InterPro IPR001387 http://www.ebi.ac.uk/interpro/entry/IPR001387 InterPro IPR010982 http://www.ebi.ac.uk/interpro/entry/IPR010982 InterPro IPR013430 http://www.ebi.ac.uk/interpro/entry/IPR013430 KEGG_Gene ecj:JW5908 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5908 KEGG_Gene eco:b1477 http://www.genome.jp/dbget-bin/www_bget?eco:b1477 OMA CRFLAKQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CRFLAKQ PROSITE PS50943 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50943 PSORT swissprot:YDDM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDDM_ECOLI PSORT-B swissprot:YDDM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDDM_ECOLI PSORT2 swissprot:YDDM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDDM_ECOLI Pfam PF01381 http://pfam.xfam.org/family/PF01381 Phobius swissprot:YDDM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDDM_ECOLI PhylomeDB P67699 http://phylomedb.org/?seqid=P67699 ProteinModelPortal P67699 http://www.proteinmodelportal.org/query/uniprot/P67699 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415994 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415994 RefSeq WP_000781370 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000781370 SMART SM00530 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00530 SMR P67699 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P67699 STRING 511145.b1477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1477&targetmode=cogs SUPFAM SSF47413 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47413 TIGRFAMs TIGR02607 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02607 UniProtKB YDDM_ECOLI http://www.uniprot.org/uniprot/YDDM_ECOLI UniProtKB-AC P67699 http://www.uniprot.org/uniprot/P67699 charge swissprot:YDDM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDDM_ECOLI eggNOG COG3093 http://eggnogapi.embl.de/nog_data/html/tree/COG3093 eggNOG ENOG41084S7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41084S7 epestfind swissprot:YDDM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDDM_ECOLI garnier swissprot:YDDM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDDM_ECOLI helixturnhelix swissprot:YDDM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDDM_ECOLI hmoment swissprot:YDDM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDDM_ECOLI iep swissprot:YDDM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDDM_ECOLI inforesidue swissprot:YDDM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDDM_ECOLI octanol swissprot:YDDM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDDM_ECOLI pepcoil swissprot:YDDM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDDM_ECOLI pepdigest swissprot:YDDM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDDM_ECOLI pepinfo swissprot:YDDM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDDM_ECOLI pepnet swissprot:YDDM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDDM_ECOLI pepstats swissprot:YDDM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDDM_ECOLI pepwheel swissprot:YDDM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDDM_ECOLI pepwindow swissprot:YDDM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDDM_ECOLI sigcleave swissprot:YDDM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDDM_ECOLI ## Database ID URL or Descriptions # BioGrid 4263241 403 # EcoGene EG12305 sapF # FUNCTION SAPF_ECOLI Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016887 ATPase activity; IEA:InterPro. # GO_process GO:0015031 protein transport; IEA:UniProtKB-KW. # GO_process GO:0015833 peptide transport; IEA:UniProtKB-KW. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # Gene3D 3.40.50.300 -; 1. # INTERACTION SAPF_ECOLI P0A9U3 ybiT; NbExp=2; IntAct=EBI-558765, EBI-558999; # IntAct P0AAH8 10 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00324 Dipeptide transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism SAPF_ECOLI Escherichia coli (strain K12) # PATRIC 32117850 VBIEscCol129921_1345 # PIR E64877 E64877 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # Pfam PF00005 ABC_tran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SAPF_ECOLI Peptide transport system ATP-binding protein SapF # RefSeq NP_415806 NC_000913.3 # RefSeq WP_000573407 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA # SUBCELLULAR LOCATION SAPF_ECOLI Cell inner membrane {ECO 0000305}; Peripheral membrane protein {ECO 0000305}. # SUPFAM SSF52540 SSF52540 # TCDB 3.A.1.5.42 the atp-binding cassette (abc) superfamily # eggNOG COG4167 LUCA # eggNOG ENOG4108JQ2 Bacteria BLAST swissprot:SAPF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SAPF_ECOLI BioCyc ECOL316407:JW1283-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1283-MONOMER BioCyc EcoCyc:SAPF-MONOMER http://biocyc.org/getid?id=EcoCyc:SAPF-MONOMER COG COG1124 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1124 DIP DIP-35903N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35903N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U08190 http://www.ebi.ac.uk/ena/data/view/U08190 EMBL X97282 http://www.ebi.ac.uk/ena/data/view/X97282 EchoBASE EB2211 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2211 EcoGene EG12305 http://www.ecogene.org/geneInfo.php?eg_id=EG12305 EnsemblBacteria AAC74372 http://www.ensemblgenomes.org/id/AAC74372 EnsemblBacteria AAC74372 http://www.ensemblgenomes.org/id/AAC74372 EnsemblBacteria BAA14843 http://www.ensemblgenomes.org/id/BAA14843 EnsemblBacteria BAA14843 http://www.ensemblgenomes.org/id/BAA14843 EnsemblBacteria BAA14843 http://www.ensemblgenomes.org/id/BAA14843 EnsemblBacteria b1290 http://www.ensemblgenomes.org/id/b1290 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_process GO:0015031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031 GO_process GO:0015833 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015833 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945335 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945335 InParanoid P0AAH8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAH8 IntAct P0AAH8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAH8* InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1283 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1283 KEGG_Gene eco:b1290 http://www.genome.jp/dbget-bin/www_bget?eco:b1290 KEGG_Orthology KO:K12372 http://www.genome.jp/dbget-bin/www_bget?KO:K12372 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA QIRMIFQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QIRMIFQ PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:SAPF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SAPF_ECOLI PSORT-B swissprot:SAPF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SAPF_ECOLI PSORT2 swissprot:SAPF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SAPF_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Phobius swissprot:SAPF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SAPF_ECOLI PhylomeDB P0AAH8 http://phylomedb.org/?seqid=P0AAH8 ProteinModelPortal P0AAH8 http://www.proteinmodelportal.org/query/uniprot/P0AAH8 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415806 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415806 RefSeq WP_000573407 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000573407 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P0AAH8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAH8 STRING 511145.b1290 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1290&targetmode=cogs STRING COG1124 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1124&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.5.42 http://www.tcdb.org/search/result.php?tc=3.A.1.5.42 UniProtKB SAPF_ECOLI http://www.uniprot.org/uniprot/SAPF_ECOLI UniProtKB-AC P0AAH8 http://www.uniprot.org/uniprot/P0AAH8 charge swissprot:SAPF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SAPF_ECOLI eggNOG COG4167 http://eggnogapi.embl.de/nog_data/html/tree/COG4167 eggNOG ENOG4108JQ2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108JQ2 epestfind swissprot:SAPF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SAPF_ECOLI garnier swissprot:SAPF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SAPF_ECOLI helixturnhelix swissprot:SAPF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SAPF_ECOLI hmoment swissprot:SAPF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SAPF_ECOLI iep swissprot:SAPF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SAPF_ECOLI inforesidue swissprot:SAPF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SAPF_ECOLI octanol swissprot:SAPF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SAPF_ECOLI pepcoil swissprot:SAPF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SAPF_ECOLI pepdigest swissprot:SAPF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SAPF_ECOLI pepinfo swissprot:SAPF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SAPF_ECOLI pepnet swissprot:SAPF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SAPF_ECOLI pepstats swissprot:SAPF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SAPF_ECOLI pepwheel swissprot:SAPF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SAPF_ECOLI pepwindow swissprot:SAPF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SAPF_ECOLI sigcleave swissprot:SAPF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SAPF_ECOLI ## Database ID URL or Descriptions # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # Organism YUAM_ECOLI Escherichia coli (strain K12) # RecName YUAM_ECOLI Uncharacterized protein YuaM # RefSeq NP_061403 NC_002483.1 # RefSeq WP_010892526 NC_002483.1 # SIMILARITY Belongs to the FliR/MopE/SpaR family. {ECO 0000305}. # SUBCELLULAR LOCATION YUAM_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. BLAST swissprot:YUAM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YUAM_ECOLI EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 1263542 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263542 OMA RTINEMS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RTINEMS PSORT swissprot:YUAM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YUAM_ECOLI PSORT-B swissprot:YUAM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YUAM_ECOLI PSORT2 swissprot:YUAM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YUAM_ECOLI Phobius swissprot:YUAM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YUAM_ECOLI ProteinModelPortal Q9JMS7 http://www.proteinmodelportal.org/query/uniprot/Q9JMS7 RefSeq NP_061403 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061403 RefSeq WP_010892526 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_010892526 SMR Q9JMS7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9JMS7 UniProtKB YUAM_ECOLI http://www.uniprot.org/uniprot/YUAM_ECOLI UniProtKB-AC Q9JMS7 http://www.uniprot.org/uniprot/Q9JMS7 charge swissprot:YUAM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YUAM_ECOLI epestfind swissprot:YUAM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YUAM_ECOLI garnier swissprot:YUAM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YUAM_ECOLI helixturnhelix swissprot:YUAM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YUAM_ECOLI hmoment swissprot:YUAM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YUAM_ECOLI iep swissprot:YUAM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YUAM_ECOLI inforesidue swissprot:YUAM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YUAM_ECOLI octanol swissprot:YUAM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YUAM_ECOLI pepcoil swissprot:YUAM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YUAM_ECOLI pepdigest swissprot:YUAM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YUAM_ECOLI pepinfo swissprot:YUAM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YUAM_ECOLI pepnet swissprot:YUAM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YUAM_ECOLI pepstats swissprot:YUAM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YUAM_ECOLI pepwheel swissprot:YUAM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YUAM_ECOLI pepwindow swissprot:YUAM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YUAM_ECOLI sigcleave swissprot:YUAM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YUAM_ECOLI ## Database ID URL or Descriptions # AltName AROG_ECOLI 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase # AltName AROG_ECOLI DAHP synthase # AltName AROG_ECOLI Phospho-2-keto-3-deoxyheptonate aldolase # BRENDA 2.5.1.54 2026 # BioGrid 4261709 10 # CATALYTIC ACTIVITY AROG_ECOLI Phosphoenolpyruvate + D-erythrose 4-phosphate + H(2)O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate. # EcoGene EG10079 aroG # FUNCTION AROG_ECOLI Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP). # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003849 3-deoxy-7-phosphoheptulonate synthase activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0008652 cellular amino acid biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0009073 aromatic amino acid family biosynthetic process; IBA:GO_Central. # GO_process GO:0009423 chorismate biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.70 -; 1. # IntAct P0AB91 3 # InterPro IPR006218 DAHP1/KDSA # InterPro IPR006219 DHAP_synth_1 # InterPro IPR013785 Aldolase_TIM # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis # MISCELLANEOUS AROG_ECOLI There are 3 DAHP synthases, AroG is feedback- inhibited by Phe. The other 2 DAHP synthases are Tyr- and Trp- sensitive, respectively. # Organism AROG_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21225 PTHR21225 # PATHWAY Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate step 1/7. # PATRIC 32116707 VBIEscCol129921_0779 # PDB 1GG1 X-ray; 2.00 A; A/B/C/D=1-350 # PDB 1KFL X-ray; 2.80 A; A/B/C/D/E/F/G/H=2-350 # PDB 1N8F X-ray; 1.75 A; A/B/C/D=1-350 # PDB 1QR7 X-ray; 2.60 A; A/B/C/D=1-350 # PDB 5CKS X-ray; 2.12 A; A/B/C/D=1-350 # PIR A01106 ADECHF # PIRSF PIRSF001361 DAHP_synthase # Pfam PF00793 DAHP_synth_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AROG_ECOLI Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive # RefSeq NP_415275 NC_000913.3 # RefSeq WP_001109196 NZ_LN832404.1 # SIMILARITY Belongs to the class-I DAHP synthase family. {ECO 0000305}. # SUBUNIT AROG_ECOLI Homotetramer. # TIGRFAMs TIGR00034 aroFGH # UniPathway UPA00053 UER00084 # eggNOG COG0722 LUCA # eggNOG ENOG4105E99 Bacteria BLAST swissprot:AROG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AROG_ECOLI BioCyc ECOL316407:JW0737-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0737-MONOMER BioCyc EcoCyc:AROG-MONOMER http://biocyc.org/getid?id=EcoCyc:AROG-MONOMER BioCyc MetaCyc:AROG-MONOMER http://biocyc.org/getid?id=MetaCyc:AROG-MONOMER COG COG0722 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0722 DIP DIP-35898N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35898N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1016/S0969-2126(99)80109-9 http://dx.doi.org/10.1016/S0969-2126(99)80109-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/10.13.4045 http://dx.doi.org/10.1093/nar/10.13.4045 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.5.1.54 http://www.genome.jp/dbget-bin/www_bget?EC:2.5.1.54 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01591 http://www.ebi.ac.uk/ena/data/view/J01591 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.5.1.54 http://enzyme.expasy.org/EC/2.5.1.54 EchoBASE EB0077 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0077 EcoGene EG10079 http://www.ecogene.org/geneInfo.php?eg_id=EG10079 EnsemblBacteria AAC73841 http://www.ensemblgenomes.org/id/AAC73841 EnsemblBacteria AAC73841 http://www.ensemblgenomes.org/id/AAC73841 EnsemblBacteria BAA35416 http://www.ensemblgenomes.org/id/BAA35416 EnsemblBacteria BAA35416 http://www.ensemblgenomes.org/id/BAA35416 EnsemblBacteria BAA35416 http://www.ensemblgenomes.org/id/BAA35416 EnsemblBacteria b0754 http://www.ensemblgenomes.org/id/b0754 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003849 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003849 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0008652 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008652 GO_process GO:0009073 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009073 GO_process GO:0009423 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009423 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016765 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 945605 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945605 HOGENOM HOG000220501 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220501&db=HOGENOM6 InParanoid P0AB91 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AB91 IntAct P0AB91 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AB91* IntEnz 2.5.1.54 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.5.1.54 InterPro IPR006218 http://www.ebi.ac.uk/interpro/entry/IPR006218 InterPro IPR006219 http://www.ebi.ac.uk/interpro/entry/IPR006219 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0737 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0737 KEGG_Gene eco:b0754 http://www.genome.jp/dbget-bin/www_bget?eco:b0754 KEGG_Orthology KO:K01626 http://www.genome.jp/dbget-bin/www_bget?KO:K01626 KEGG_Pathway ko00400 http://www.genome.jp/kegg-bin/show_pathway?ko00400 KEGG_Reaction rn:R01826 http://www.genome.jp/dbget-bin/www_bget?rn:R01826 OMA GNIKIAT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GNIKIAT PANTHER PTHR21225 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21225 PDB 1GG1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1GG1 PDB 1KFL http://www.ebi.ac.uk/pdbe-srv/view/entry/1KFL PDB 1N8F http://www.ebi.ac.uk/pdbe-srv/view/entry/1N8F PDB 1QR7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1QR7 PDB 5CKS http://www.ebi.ac.uk/pdbe-srv/view/entry/5CKS PDBsum 1GG1 http://www.ebi.ac.uk/pdbsum/1GG1 PDBsum 1KFL http://www.ebi.ac.uk/pdbsum/1KFL PDBsum 1N8F http://www.ebi.ac.uk/pdbsum/1N8F PDBsum 1QR7 http://www.ebi.ac.uk/pdbsum/1QR7 PDBsum 5CKS http://www.ebi.ac.uk/pdbsum/5CKS PSORT swissprot:AROG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AROG_ECOLI PSORT-B swissprot:AROG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AROG_ECOLI PSORT2 swissprot:AROG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AROG_ECOLI Pfam PF00793 http://pfam.xfam.org/family/PF00793 Phobius swissprot:AROG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AROG_ECOLI PhylomeDB P0AB91 http://phylomedb.org/?seqid=P0AB91 ProteinModelPortal P0AB91 http://www.proteinmodelportal.org/query/uniprot/P0AB91 PubMed 10425687 http://www.ncbi.nlm.nih.gov/pubmed/10425687 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 6125934 http://www.ncbi.nlm.nih.gov/pubmed/6125934 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_415275 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415275 RefSeq WP_001109196 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001109196 SMR P0AB91 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AB91 STRING 511145.b0754 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0754&targetmode=cogs STRING COG0722 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0722&targetmode=cogs SWISS-2DPAGE P0AB91 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AB91 TIGRFAMs TIGR00034 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00034 UniProtKB AROG_ECOLI http://www.uniprot.org/uniprot/AROG_ECOLI UniProtKB-AC P0AB91 http://www.uniprot.org/uniprot/P0AB91 charge swissprot:AROG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AROG_ECOLI eggNOG COG0722 http://eggnogapi.embl.de/nog_data/html/tree/COG0722 eggNOG ENOG4105E99 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E99 epestfind swissprot:AROG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AROG_ECOLI garnier swissprot:AROG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AROG_ECOLI helixturnhelix swissprot:AROG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AROG_ECOLI hmoment swissprot:AROG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AROG_ECOLI iep swissprot:AROG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AROG_ECOLI inforesidue swissprot:AROG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AROG_ECOLI octanol swissprot:AROG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AROG_ECOLI pepcoil swissprot:AROG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AROG_ECOLI pepdigest swissprot:AROG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AROG_ECOLI pepinfo swissprot:AROG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AROG_ECOLI pepnet swissprot:AROG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AROG_ECOLI pepstats swissprot:AROG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AROG_ECOLI pepwheel swissprot:AROG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AROG_ECOLI pepwindow swissprot:AROG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AROG_ECOLI sigcleave swissprot:AROG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AROG_ECOLI ## Database ID URL or Descriptions # BioGrid 4260853 262 # EcoGene EG12262 yhjR # GO_process GO:0090540 bacterial cellulose biosynthetic process; IMP:EcoCyc. # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # IntAct P0ADJ3 2 # InterPro IPR024487 CBP_BcsR # Organism YHJR_ECOLI Escherichia coli (strain K12) # PATRIC 32122536 VBIEscCol129921_3646 # PIR S47757 S47757 # Pfam PF10945 CBP_BcsR # ProDom PD053230 PD053230 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHJR_ECOLI Uncharacterized protein YhjR # RefSeq NP_417992 NC_000913.3 # RefSeq WP_001063318 NZ_LN832404.1 # eggNOG ENOG410661M Bacteria # eggNOG ENOG41127QD LUCA BLAST swissprot:YHJR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHJR_ECOLI BioCyc ECOL316407:JW3503-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3503-MONOMER BioCyc EcoCyc:EG12262-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12262-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2171 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2171 EcoGene EG12262 http://www.ecogene.org/geneInfo.php?eg_id=EG12262 EnsemblBacteria AAC76560 http://www.ensemblgenomes.org/id/AAC76560 EnsemblBacteria AAC76560 http://www.ensemblgenomes.org/id/AAC76560 EnsemblBacteria BAE77760 http://www.ensemblgenomes.org/id/BAE77760 EnsemblBacteria BAE77760 http://www.ensemblgenomes.org/id/BAE77760 EnsemblBacteria BAE77760 http://www.ensemblgenomes.org/id/BAE77760 EnsemblBacteria b3535 http://www.ensemblgenomes.org/id/b3535 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0090540 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090540 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 948051 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948051 HOGENOM HOG000219553 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219553&db=HOGENOM6 IntAct P0ADJ3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADJ3* InterPro IPR024487 http://www.ebi.ac.uk/interpro/entry/IPR024487 KEGG_Gene ecj:JW3503 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3503 KEGG_Gene eco:b3535 http://www.genome.jp/dbget-bin/www_bget?eco:b3535 OMA HNNEPAT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HNNEPAT PSORT swissprot:YHJR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHJR_ECOLI PSORT-B swissprot:YHJR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHJR_ECOLI PSORT2 swissprot:YHJR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHJR_ECOLI Pfam PF10945 http://pfam.xfam.org/family/PF10945 Phobius swissprot:YHJR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHJR_ECOLI ProteinModelPortal P0ADJ3 http://www.proteinmodelportal.org/query/uniprot/P0ADJ3 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417992 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417992 RefSeq WP_001063318 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001063318 STRING 511145.b3535 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3535&targetmode=cogs UniProtKB YHJR_ECOLI http://www.uniprot.org/uniprot/YHJR_ECOLI UniProtKB-AC P0ADJ3 http://www.uniprot.org/uniprot/P0ADJ3 charge swissprot:YHJR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHJR_ECOLI eggNOG ENOG410661M http://eggnogapi.embl.de/nog_data/html/tree/ENOG410661M eggNOG ENOG41127QD http://eggnogapi.embl.de/nog_data/html/tree/ENOG41127QD epestfind swissprot:YHJR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHJR_ECOLI garnier swissprot:YHJR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHJR_ECOLI helixturnhelix swissprot:YHJR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHJR_ECOLI hmoment swissprot:YHJR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHJR_ECOLI iep swissprot:YHJR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHJR_ECOLI inforesidue swissprot:YHJR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHJR_ECOLI octanol swissprot:YHJR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHJR_ECOLI pepcoil swissprot:YHJR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHJR_ECOLI pepdigest swissprot:YHJR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHJR_ECOLI pepinfo swissprot:YHJR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHJR_ECOLI pepnet swissprot:YHJR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHJR_ECOLI pepstats swissprot:YHJR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHJR_ECOLI pepwheel swissprot:YHJR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHJR_ECOLI pepwindow swissprot:YHJR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHJR_ECOLI sigcleave swissprot:YHJR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHJR_ECOLI ## Database ID URL or Descriptions # BioGrid 4261092 94 # CDD cd08071 MPN_DUF2466 # EcoGene EG14331 ykfG # IntAct Q47685 2 # InterPro IPR001405 RadC # InterPro IPR020891 UPF0758_CS # InterPro IPR025657 RadC_JAB # Organism YKFG_ECOLI Escherichia coli (strain K12) # PATRIC 32115611 VBIEscCol129921_0249 # PIR G64749 G64749 # PROSITE PS01302 UPF0758 # Pfam PF04002 RadC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YKFG_ECOLI UPF0758 protein YkfG # RefSeq NP_414781 NC_000913.3 # RefSeq WP_000811693 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0758 family. {ECO 0000305}. # TIGRFAMs TIGR00608 radc # eggNOG COG2003 LUCA # eggNOG ENOG4108XS9 Bacteria BLAST swissprot:YKFG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YKFG_ECOLI BioCyc ECOL316407:JW0236-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0236-MONOMER BioCyc EcoCyc:G6122-MONOMER http://biocyc.org/getid?id=EcoCyc:G6122-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EchoBASE EB4077 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4077 EcoGene EG14331 http://www.ecogene.org/geneInfo.php?eg_id=EG14331 EnsemblBacteria AAC73350 http://www.ensemblgenomes.org/id/AAC73350 EnsemblBacteria AAC73350 http://www.ensemblgenomes.org/id/AAC73350 EnsemblBacteria BAA77916 http://www.ensemblgenomes.org/id/BAA77916 EnsemblBacteria BAA77916 http://www.ensemblgenomes.org/id/BAA77916 EnsemblBacteria BAA77916 http://www.ensemblgenomes.org/id/BAA77916 EnsemblBacteria b0247 http://www.ensemblgenomes.org/id/b0247 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 944930 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944930 HOGENOM HOG000273376 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000273376&db=HOGENOM6 InParanoid Q47685 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q47685 IntAct Q47685 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q47685* InterPro IPR001405 http://www.ebi.ac.uk/interpro/entry/IPR001405 InterPro IPR020891 http://www.ebi.ac.uk/interpro/entry/IPR020891 InterPro IPR025657 http://www.ebi.ac.uk/interpro/entry/IPR025657 KEGG_Gene ecj:JW0236 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0236 KEGG_Gene eco:b0247 http://www.genome.jp/dbget-bin/www_bget?eco:b0247 OMA DICFASS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DICFASS PROSITE PS01302 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01302 PSORT swissprot:YKFG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YKFG_ECOLI PSORT-B swissprot:YKFG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YKFG_ECOLI PSORT2 swissprot:YKFG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YKFG_ECOLI Pfam PF04002 http://pfam.xfam.org/family/PF04002 Phobius swissprot:YKFG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YKFG_ECOLI PhylomeDB Q47685 http://phylomedb.org/?seqid=Q47685 ProteinModelPortal Q47685 http://www.proteinmodelportal.org/query/uniprot/Q47685 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414781 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414781 RefSeq WP_000811693 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000811693 SMR Q47685 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q47685 STRING 511145.b0247 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0247&targetmode=cogs TIGRFAMs TIGR00608 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00608 UniProtKB YKFG_ECOLI http://www.uniprot.org/uniprot/YKFG_ECOLI UniProtKB-AC Q47685 http://www.uniprot.org/uniprot/Q47685 charge swissprot:YKFG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YKFG_ECOLI eggNOG COG2003 http://eggnogapi.embl.de/nog_data/html/tree/COG2003 eggNOG ENOG4108XS9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108XS9 epestfind swissprot:YKFG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YKFG_ECOLI garnier swissprot:YKFG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YKFG_ECOLI helixturnhelix swissprot:YKFG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YKFG_ECOLI hmoment swissprot:YKFG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YKFG_ECOLI iep swissprot:YKFG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YKFG_ECOLI inforesidue swissprot:YKFG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YKFG_ECOLI octanol swissprot:YKFG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YKFG_ECOLI pepcoil swissprot:YKFG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YKFG_ECOLI pepdigest swissprot:YKFG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YKFG_ECOLI pepinfo swissprot:YKFG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YKFG_ECOLI pepnet swissprot:YKFG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YKFG_ECOLI pepstats swissprot:YKFG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YKFG_ECOLI pepwheel swissprot:YKFG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YKFG_ECOLI pepwindow swissprot:YKFG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YKFG_ECOLI sigcleave swissprot:YKFG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YKFG_ECOLI ## Database ID URL or Descriptions # AltName DHPS_ECOLI Dihydropteroate pyrophosphorylase # BIOPHYSICOCHEMICAL PROPERTIES DHPS_ECOLI Kinetic parameters KM=2.5 uM for 4-aminobenzoate {ECO 0000269|PubMed 4304228}; pH dependence Optimum pH is 8.5. {ECO 0000269|PubMed 4304228}; # BRENDA 2.5.1.15 2167 # CATALYTIC ACTIVITY DHPS_ECOLI 6-hydroxymethyl-7,8-dihydropterin diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate. {ECO 0000269|PubMed 368012, ECO 0000269|PubMed 4304228}. # CDD cd00739 DHPS # COFACTOR DHPS_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 4304228}; Note=Magnesium is required for activity, even if it seems to interact primarily with the substrate. {ECO 0000269|PubMed 4304228, ECO 0000305}; # DrugBank DB00259 Sulfanilamide # DrugBank DB00263 Sulfisoxazole # DrugBank DB00576 Sulfamethizole # DrugBank DB00634 Sulfacetamide # DrugBank DB01015 Sulfamethoxazole # DrugBank DB01298 Sulfacytine # DrugBank DB01581 Sulfamerazine # DrugBank DB01582 Sulfamethazine # DrugBank DB06729 Sulfaphenazole # EcoGene EG50011 folP # FUNCTION DHPS_ECOLI Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives. {ECO 0000269|PubMed 368012}. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004156 dihydropteroate synthase activity; IDA:EcoliWiki. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0042493 response to drug; IMP:EcoliWiki. # GO_process GO:0046654 tetrahydrofolate biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0046656 folic acid biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.20.20.20 -; 1. # InterPro IPR000489 Pterin-binding_dom # InterPro IPR006390 DHP_synth # InterPro IPR011005 Dihydropteroate_synth-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00790 Folate biosynthesis # Organism DHPS_ECOLI Escherichia coli (strain K12) # PATHWAY Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8- dihydropteridine diphosphate and 4-aminobenzoate step 1/2. # PATRIC 32121772 VBIEscCol129921_3270 # PDB 1AJ0 X-ray; 2.00 A; A=1-282 # PDB 1AJ2 X-ray; 2.00 A; A=1-282 # PDB 1AJZ X-ray; 2.00 A; A=1-282 # PIR A43326 A43326 # PROSITE PS00792 DHPS_1 # PROSITE PS00793 DHPS_2 # PROSITE PS50972 PTERIN_BINDING # Pfam PF00809 Pterin_bind # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Dihydropteroate synthase {ECO:0000303|PubMed 1522070} # RefSeq NP_417644 NC_000913.3 # RefSeq WP_000764731 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA57978.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the DHPS family. {ECO 0000305}. # SIMILARITY Contains 1 pterin-binding domain. {ECO:0000255|PROSITE-ProRule PRU00334}. # SUBUNIT DHPS_ECOLI Homodimer. {ECO 0000269|PubMed 4304228, ECO 0000269|PubMed 9187658}. # SUPFAM SSF51717 SSF51717 # TIGRFAMs TIGR01496 DHPS # UniPathway UPA00077 UER00156 # eggNOG COG0294 LUCA # eggNOG ENOG4105EEI Bacteria BLAST swissprot:DHPS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DHPS_ECOLI BioCyc ECOL316407:JW3144-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3144-MONOMER BioCyc EcoCyc:H2PTEROATESYNTH-MONOMER http://biocyc.org/getid?id=EcoCyc:H2PTEROATESYNTH-MONOMER BioCyc MetaCyc:H2PTEROATESYNTH-MONOMER http://biocyc.org/getid?id=MetaCyc:H2PTEROATESYNTH-MONOMER COG COG0294 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0294 DIP DIP-47922N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47922N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb0697-490 http://dx.doi.org/10.1038/nsb0697-490 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB00259 http://www.drugbank.ca/drugs/DB00259 DrugBank DB00263 http://www.drugbank.ca/drugs/DB00263 DrugBank DB00576 http://www.drugbank.ca/drugs/DB00576 DrugBank DB00634 http://www.drugbank.ca/drugs/DB00634 DrugBank DB01015 http://www.drugbank.ca/drugs/DB01015 DrugBank DB01298 http://www.drugbank.ca/drugs/DB01298 DrugBank DB01581 http://www.drugbank.ca/drugs/DB01581 DrugBank DB01582 http://www.drugbank.ca/drugs/DB01582 DrugBank DB06729 http://www.drugbank.ca/drugs/DB06729 EC_number EC:2.5.1.15 {ECO:0000269|PubMed:368012} http://www.genome.jp/dbget-bin/www_bget?EC:2.5.1.15 {ECO:0000269|PubMed:368012} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L06494 http://www.ebi.ac.uk/ena/data/view/L06494 EMBL L12968 http://www.ebi.ac.uk/ena/data/view/L12968 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U01376 http://www.ebi.ac.uk/ena/data/view/U01376 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X68776 http://www.ebi.ac.uk/ena/data/view/X68776 EMBL X68777 http://www.ebi.ac.uk/ena/data/view/X68777 ENZYME 2.5.1.15 {ECO:0000269|PubMed:368012} http://enzyme.expasy.org/EC/2.5.1.15 {ECO:0000269|PubMed:368012} EchoBASE EB4304 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4304 EcoGene EG50011 http://www.ecogene.org/geneInfo.php?eg_id=EG50011 EnsemblBacteria AAC76209 http://www.ensemblgenomes.org/id/AAC76209 EnsemblBacteria AAC76209 http://www.ensemblgenomes.org/id/AAC76209 EnsemblBacteria BAE77221 http://www.ensemblgenomes.org/id/BAE77221 EnsemblBacteria BAE77221 http://www.ensemblgenomes.org/id/BAE77221 EnsemblBacteria BAE77221 http://www.ensemblgenomes.org/id/BAE77221 EnsemblBacteria b3177 http://www.ensemblgenomes.org/id/b3177 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004156 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004156 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0042493 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493 GO_process GO:0046654 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046654 GO_process GO:0046656 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046656 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016765 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.20.20.20 http://www.cathdb.info/version/latest/superfamily/3.20.20.20 GeneID 947691 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947691 HOGENOM HOG000217510 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000217510&db=HOGENOM6 InParanoid P0AC13 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AC13 IntAct P0AC13 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AC13* IntEnz 2.5.1.15 {ECO:0000269|PubMed:368012} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.5.1.15 {ECO:0000269|PubMed:368012} InterPro IPR000489 http://www.ebi.ac.uk/interpro/entry/IPR000489 InterPro IPR006390 http://www.ebi.ac.uk/interpro/entry/IPR006390 InterPro IPR011005 http://www.ebi.ac.uk/interpro/entry/IPR011005 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3144 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3144 KEGG_Gene eco:b3177 http://www.genome.jp/dbget-bin/www_bget?eco:b3177 KEGG_Orthology KO:K00796 http://www.genome.jp/dbget-bin/www_bget?KO:K00796 KEGG_Pathway ko00790 http://www.genome.jp/kegg-bin/show_pathway?ko00790 KEGG_Reaction rn:R03066 http://www.genome.jp/dbget-bin/www_bget?rn:R03066 KEGG_Reaction rn:R03067 http://www.genome.jp/dbget-bin/www_bget?rn:R03067 MINT MINT-1268009 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1268009 OMA SIDTYHA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SIDTYHA PDB 1AJ0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1AJ0 PDB 1AJ2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1AJ2 PDB 1AJZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1AJZ PDBsum 1AJ0 http://www.ebi.ac.uk/pdbsum/1AJ0 PDBsum 1AJ2 http://www.ebi.ac.uk/pdbsum/1AJ2 PDBsum 1AJZ http://www.ebi.ac.uk/pdbsum/1AJZ PROSITE PS00792 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00792 PROSITE PS00793 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00793 PROSITE PS50972 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50972 PSORT swissprot:DHPS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DHPS_ECOLI PSORT-B swissprot:DHPS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DHPS_ECOLI PSORT2 swissprot:DHPS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DHPS_ECOLI Pfam PF00809 http://pfam.xfam.org/family/PF00809 Phobius swissprot:DHPS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DHPS_ECOLI PhylomeDB P0AC13 http://phylomedb.org/?seqid=P0AC13 ProteinModelPortal P0AC13 http://www.proteinmodelportal.org/query/uniprot/P0AC13 PubMed 1522070 http://www.ncbi.nlm.nih.gov/pubmed/1522070 PubMed 1657875 http://www.ncbi.nlm.nih.gov/pubmed/1657875 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 368012 http://www.ncbi.nlm.nih.gov/pubmed/368012 PubMed 4304228 http://www.ncbi.nlm.nih.gov/pubmed/4304228 PubMed 8304179 http://www.ncbi.nlm.nih.gov/pubmed/8304179 PubMed 9187658 http://www.ncbi.nlm.nih.gov/pubmed/9187658 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417644 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417644 RefSeq WP_000764731 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000764731 SMR P0AC13 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AC13 STRING 511145.b3177 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3177&targetmode=cogs STRING COG0294 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0294&targetmode=cogs SUPFAM SSF51717 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51717 TIGRFAMs TIGR01496 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01496 UniProtKB DHPS_ECOLI http://www.uniprot.org/uniprot/DHPS_ECOLI UniProtKB-AC P0AC13 http://www.uniprot.org/uniprot/P0AC13 charge swissprot:DHPS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DHPS_ECOLI eggNOG COG0294 http://eggnogapi.embl.de/nog_data/html/tree/COG0294 eggNOG ENOG4105EEI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EEI epestfind swissprot:DHPS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DHPS_ECOLI garnier swissprot:DHPS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DHPS_ECOLI helixturnhelix swissprot:DHPS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DHPS_ECOLI hmoment swissprot:DHPS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DHPS_ECOLI iep swissprot:DHPS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DHPS_ECOLI inforesidue swissprot:DHPS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DHPS_ECOLI octanol swissprot:DHPS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DHPS_ECOLI pepcoil swissprot:DHPS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DHPS_ECOLI pepdigest swissprot:DHPS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DHPS_ECOLI pepinfo swissprot:DHPS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DHPS_ECOLI pepnet swissprot:DHPS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DHPS_ECOLI pepstats swissprot:DHPS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DHPS_ECOLI pepwheel swissprot:DHPS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DHPS_ECOLI pepwindow swissprot:DHPS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DHPS_ECOLI sigcleave swissprot:DHPS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DHPS_ECOLI ## Database ID URL or Descriptions # BioGrid 4263034 19 # EcoGene EG12656 mdaB # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008753 NADPH dehydrogenase (quinone) activity; IDA:EcoCyc. # GO_function GO:0050660 flavin adenine dinucleotide binding; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.360 -; 1. # IntAct P0AEY5 3 # InterPro IPR003680 Flavodoxin_fold # InterPro IPR029039 Flavoprotein-like_dom # Organism MDAB_ECOLI Escherichia coli (strain K12) # PATRIC 32121466 VBIEscCol129921_3120 # PDB 2B3D X-ray; 2.10 A; A/B=2-193 # PIR I80319 I80319 # Pfam PF02525 Flavodoxin_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MDAB_ECOLI Modulator of drug activity B # RefSeq NP_417500 NC_000913.3 # RefSeq WP_000065430 NZ_LN832404.1 # SIMILARITY To H.influenzae HI_0648 and S.pombe SPAC5H10.05c. {ECO 0000305}. # SUPFAM SSF52218 SSF52218 # eggNOG COG2249 LUCA # eggNOG ENOG4105NF4 Bacteria BLAST swissprot:MDAB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MDAB_ECOLI BioCyc ECOL316407:JW2996-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2996-MONOMER BioCyc EcoCyc:EG12656-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12656-MONOMER BioCyc MetaCyc:EG12656-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12656-MONOMER COG COG2249 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2249 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.92.19.8950 http://dx.doi.org/10.1073/pnas.92.19.8950 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18656 http://www.ebi.ac.uk/ena/data/view/U18656 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2524 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2524 EcoGene EG12656 http://www.ecogene.org/geneInfo.php?eg_id=EG12656 EnsemblBacteria AAC76064 http://www.ensemblgenomes.org/id/AAC76064 EnsemblBacteria AAC76064 http://www.ensemblgenomes.org/id/AAC76064 EnsemblBacteria BAE77084 http://www.ensemblgenomes.org/id/BAE77084 EnsemblBacteria BAE77084 http://www.ensemblgenomes.org/id/BAE77084 EnsemblBacteria BAE77084 http://www.ensemblgenomes.org/id/BAE77084 EnsemblBacteria b3028 http://www.ensemblgenomes.org/id/b3028 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008753 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008753 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.360 http://www.cathdb.info/version/latest/superfamily/3.40.50.360 GeneID 947512 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947512 HOGENOM HOG000063966 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000063966&db=HOGENOM6 InParanoid P0AEY5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEY5 IntAct P0AEY5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEY5* InterPro IPR003680 http://www.ebi.ac.uk/interpro/entry/IPR003680 InterPro IPR029039 http://www.ebi.ac.uk/interpro/entry/IPR029039 KEGG_Gene ecj:JW2996 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2996 KEGG_Gene eco:b3028 http://www.genome.jp/dbget-bin/www_bget?eco:b3028 KEGG_Orthology KO:K03923 http://www.genome.jp/dbget-bin/www_bget?KO:K03923 OMA PTFICND http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PTFICND PDB 2B3D http://www.ebi.ac.uk/pdbe-srv/view/entry/2B3D PDBsum 2B3D http://www.ebi.ac.uk/pdbsum/2B3D PSORT swissprot:MDAB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MDAB_ECOLI PSORT-B swissprot:MDAB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MDAB_ECOLI PSORT2 swissprot:MDAB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MDAB_ECOLI Pfam PF02525 http://pfam.xfam.org/family/PF02525 Phobius swissprot:MDAB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MDAB_ECOLI PhylomeDB P0AEY5 http://phylomedb.org/?seqid=P0AEY5 ProteinModelPortal P0AEY5 http://www.proteinmodelportal.org/query/uniprot/P0AEY5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7568050 http://www.ncbi.nlm.nih.gov/pubmed/7568050 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417500 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417500 RefSeq WP_000065430 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000065430 SMR P0AEY5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEY5 STRING 511145.b3028 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3028&targetmode=cogs STRING COG2249 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2249&targetmode=cogs SUPFAM SSF52218 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52218 UniProtKB MDAB_ECOLI http://www.uniprot.org/uniprot/MDAB_ECOLI UniProtKB-AC P0AEY5 http://www.uniprot.org/uniprot/P0AEY5 charge swissprot:MDAB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MDAB_ECOLI eggNOG COG2249 http://eggnogapi.embl.de/nog_data/html/tree/COG2249 eggNOG ENOG4105NF4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105NF4 epestfind swissprot:MDAB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MDAB_ECOLI garnier swissprot:MDAB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MDAB_ECOLI helixturnhelix swissprot:MDAB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MDAB_ECOLI hmoment swissprot:MDAB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MDAB_ECOLI iep swissprot:MDAB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MDAB_ECOLI inforesidue swissprot:MDAB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MDAB_ECOLI octanol swissprot:MDAB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MDAB_ECOLI pepcoil swissprot:MDAB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MDAB_ECOLI pepdigest swissprot:MDAB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MDAB_ECOLI pepinfo swissprot:MDAB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MDAB_ECOLI pepnet swissprot:MDAB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MDAB_ECOLI pepstats swissprot:MDAB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MDAB_ECOLI pepwheel swissprot:MDAB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MDAB_ECOLI pepwindow swissprot:MDAB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MDAB_ECOLI sigcleave swissprot:MDAB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MDAB_ECOLI ## Database ID URL or Descriptions # BioGrid 4262815 11 # EcoGene EG12830 ybaM # GO_process GO:0036460 cellular response to cell envelope stress; IMP:EcoCyc. # GOslim_process GO:0006950 response to stress # InterPro IPR019630 DUF2496_YbaM-rel # Organism YBAM_ECOLI Escherichia coli (strain K12) # PATRIC 32116087 VBIEscCol129921_0485 # PIR A64777 A64777 # Pfam PF10689 DUF2496 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBAM_ECOLI Uncharacterized protein YbaM # RefSeq NP_414999 NC_000913.3 # RefSeq WP_000051153 NZ_LN832404.1 # eggNOG ENOG4106428 Bacteria # eggNOG ENOG410XUBV LUCA BLAST swissprot:YBAM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBAM_ECOLI BioCyc ECOL316407:JW0455-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0455-MONOMER BioCyc EcoCyc:EG12830-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12830-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D13958 http://www.ebi.ac.uk/ena/data/view/D13958 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EchoBASE EB2679 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2679 EcoGene EG12830 http://www.ecogene.org/geneInfo.php?eg_id=EG12830 EnsemblBacteria AAC73568 http://www.ensemblgenomes.org/id/AAC73568 EnsemblBacteria AAC73568 http://www.ensemblgenomes.org/id/AAC73568 EnsemblBacteria BAE76245 http://www.ensemblgenomes.org/id/BAE76245 EnsemblBacteria BAE76245 http://www.ensemblgenomes.org/id/BAE76245 EnsemblBacteria BAE76245 http://www.ensemblgenomes.org/id/BAE76245 EnsemblBacteria b0466 http://www.ensemblgenomes.org/id/b0466 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0036460 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036460 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 945144 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945144 HOGENOM HOG000275679 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275679&db=HOGENOM6 IntAct P45807 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45807* InterPro IPR019630 http://www.ebi.ac.uk/interpro/entry/IPR019630 KEGG_Gene ecj:JW0455 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0455 KEGG_Gene eco:b0466 http://www.genome.jp/dbget-bin/www_bget?eco:b0466 OMA ETNEIDP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ETNEIDP PSORT swissprot:YBAM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBAM_ECOLI PSORT-B swissprot:YBAM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBAM_ECOLI PSORT2 swissprot:YBAM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBAM_ECOLI Pfam PF10689 http://pfam.xfam.org/family/PF10689 Phobius swissprot:YBAM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBAM_ECOLI ProteinModelPortal P45807 http://www.proteinmodelportal.org/query/uniprot/P45807 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1856227 http://www.ncbi.nlm.nih.gov/pubmed/1856227 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414999 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414999 RefSeq WP_000051153 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000051153 SMR P45807 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45807 STRING 511145.b0466 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0466&targetmode=cogs UniProtKB YBAM_ECOLI http://www.uniprot.org/uniprot/YBAM_ECOLI UniProtKB-AC P45807 http://www.uniprot.org/uniprot/P45807 charge swissprot:YBAM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBAM_ECOLI eggNOG ENOG4106428 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106428 eggNOG ENOG410XUBV http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XUBV epestfind swissprot:YBAM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBAM_ECOLI garnier swissprot:YBAM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBAM_ECOLI helixturnhelix swissprot:YBAM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBAM_ECOLI hmoment swissprot:YBAM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBAM_ECOLI iep swissprot:YBAM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBAM_ECOLI inforesidue swissprot:YBAM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBAM_ECOLI octanol swissprot:YBAM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBAM_ECOLI pepcoil swissprot:YBAM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBAM_ECOLI pepdigest swissprot:YBAM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBAM_ECOLI pepinfo swissprot:YBAM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBAM_ECOLI pepnet swissprot:YBAM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBAM_ECOLI pepstats swissprot:YBAM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBAM_ECOLI pepwheel swissprot:YBAM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBAM_ECOLI pepwindow swissprot:YBAM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBAM_ECOLI sigcleave swissprot:YBAM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBAM_ECOLI ## Database ID URL or Descriptions # AltName GNTT_ECOLI Gluconate permease # AltName GNTT_ECOLI Gnt-I system # BioGrid 4261217 13 # EcoGene EG12380 gntT # FUNCTION GNTT_ECOLI Part of the gluconate utilization system Gnt-I; high- affinity intake of gluconate. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_component GO:0016020 membrane; IDA:EcoCyc. # GO_function GO:0015128 gluconate transmembrane transporter activity; IBA:GO_Central. # GO_process GO:0008643 carbohydrate transport; IEA:UniProtKB-KW. # GO_process GO:0046177 D-gluconate catabolic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006810 transport # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # InterPro IPR003474 Glcn_transporter # KEGG_Brite ko02000 Transporters # Organism GNTT_ECOLI Escherichia coli (strain K12) # PATHWAY GNTT_ECOLI Carbohydrate acid metabolism; D-gluconate degradation. # PATRIC 32122268 VBIEscCol129921_3511 # PIR JC4988 JC4988 # PIRSF PIRSF002746 Gluconate_transporter # Pfam PF02447 GntP_permease # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GNTT_ECOLI High-affinity gluconate transporter # RefSeq WP_001131758 NZ_LN832404.1 # RefSeq YP_026217 NC_000913.3 # SIMILARITY Belongs to the GntP permease family. {ECO 0000305}. # SUBCELLULAR LOCATION GNTT_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # TCDB 2.A.8.1:the gluconate h(+) symporter (gntp) family # TIGRFAMs TIGR00791 gntP # eggNOG COG2610 LUCA # eggNOG ENOG4105C6Z Bacteria BLAST swissprot:GNTT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GNTT_ECOLI BioCyc ECOL316407:JW5690-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5690-MONOMER BioCyc EcoCyc:GNTT-MONOMER http://biocyc.org/getid?id=EcoCyc:GNTT-MONOMER BioCyc MetaCyc:GNTT-MONOMER http://biocyc.org/getid?id=MetaCyc:GNTT-MONOMER COG COG2610 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2610 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1099/00221287-132-11-3209 http://dx.doi.org/10.1099/00221287-132-11-3209 DOI 10.1111/j.1365-2958.1988.tb00053.x http://dx.doi.org/10.1111/j.1365-2958.1988.tb00053.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1271/bbb.60.1548 http://dx.doi.org/10.1271/bbb.60.1548 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M32793 http://www.ebi.ac.uk/ena/data/view/M32793 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2282 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2282 EcoGene EG12380 http://www.ecogene.org/geneInfo.php?eg_id=EG12380 EnsemblBacteria AAT48179 http://www.ensemblgenomes.org/id/AAT48179 EnsemblBacteria AAT48179 http://www.ensemblgenomes.org/id/AAT48179 EnsemblBacteria BAE77876 http://www.ensemblgenomes.org/id/BAE77876 EnsemblBacteria BAE77876 http://www.ensemblgenomes.org/id/BAE77876 EnsemblBacteria BAE77876 http://www.ensemblgenomes.org/id/BAE77876 EnsemblBacteria b3415 http://www.ensemblgenomes.org/id/b3415 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0015128 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015128 GO_process GO:0008643 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008643 GO_process GO:0046177 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046177 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 947924 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947924 HOGENOM HOG000237115 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000237115&db=HOGENOM6 InParanoid P39835 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39835 InterPro IPR003474 http://www.ebi.ac.uk/interpro/entry/IPR003474 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5690 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5690 KEGG_Gene eco:b3415 http://www.genome.jp/dbget-bin/www_bget?eco:b3415 KEGG_Orthology KO:K06155 http://www.genome.jp/dbget-bin/www_bget?KO:K06155 OMA MVLPKGH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MVLPKGH PSORT swissprot:GNTT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GNTT_ECOLI PSORT-B swissprot:GNTT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GNTT_ECOLI PSORT2 swissprot:GNTT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GNTT_ECOLI Pfam PF02447 http://pfam.xfam.org/family/PF02447 Phobius swissprot:GNTT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GNTT_ECOLI PhylomeDB P39835 http://phylomedb.org/?seqid=P39835 ProteinModelPortal P39835 http://www.proteinmodelportal.org/query/uniprot/P39835 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2845225 http://www.ncbi.nlm.nih.gov/pubmed/2845225 PubMed 3040894 http://www.ncbi.nlm.nih.gov/pubmed/3040894 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 8987614 http://www.ncbi.nlm.nih.gov/pubmed/8987614 PubMed 9045817 http://www.ncbi.nlm.nih.gov/pubmed/9045817 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001131758 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001131758 RefSeq YP_026217 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026217 STRING 511145.b3415 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3415&targetmode=cogs STRING COG2610 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2610&targetmode=cogs TCDB 2.A.8.1 http://www.tcdb.org/search/result.php?tc=2.A.8.1 TIGRFAMs TIGR00791 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00791 UniProtKB GNTT_ECOLI http://www.uniprot.org/uniprot/GNTT_ECOLI UniProtKB-AC P39835 http://www.uniprot.org/uniprot/P39835 charge swissprot:GNTT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GNTT_ECOLI eggNOG COG2610 http://eggnogapi.embl.de/nog_data/html/tree/COG2610 eggNOG ENOG4105C6Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C6Z epestfind swissprot:GNTT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GNTT_ECOLI garnier swissprot:GNTT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GNTT_ECOLI helixturnhelix swissprot:GNTT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GNTT_ECOLI hmoment swissprot:GNTT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GNTT_ECOLI iep swissprot:GNTT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GNTT_ECOLI inforesidue swissprot:GNTT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GNTT_ECOLI octanol swissprot:GNTT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GNTT_ECOLI pepcoil swissprot:GNTT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GNTT_ECOLI pepdigest swissprot:GNTT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GNTT_ECOLI pepinfo swissprot:GNTT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GNTT_ECOLI pepnet swissprot:GNTT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GNTT_ECOLI pepstats swissprot:GNTT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GNTT_ECOLI pepwheel swissprot:GNTT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GNTT_ECOLI pepwindow swissprot:GNTT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GNTT_ECOLI sigcleave swissprot:GNTT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GNTT_ECOLI ## Database ID URL or Descriptions # BioGrid 4261341 8 # CDD cd13545 PBP2_TbpA # EcoGene EG11574 tbpA # FUNCTION THIB_ECOLI Part of the ABC transporter complex ThiBPQ involved in thiamine import. {ECO 0000269|PubMed 9535878}. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IEA:InterPro. # GO_function GO:0005524 ATP binding; IEA:InterPro. # GO_function GO:0015234 thiamine transmembrane transporter activity; IEA:InterPro. # GO_function GO:0030975 thiamine binding; IEA:InterPro. # GO_function GO:0048502 thiamine-transporting ATPase activity; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # IntAct P31550 3 # InterPro IPR005948 Thi_ABC_peri-bd # InterPro IPR005967 ThiB_ABC_peri-bd # InterPro IPR006061 SBP_1_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00191 Thiamine transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism THIB_ECOLI Escherichia coli (strain K12) # PATRIC 32115237 VBIEscCol129921_0070 # PDB 2QRY X-ray; 2.25 A; A/B/C/D=19-327 # PIR D64728 D64728 # PROSITE PS01037 SBP_BACTERIAL_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName THIB_ECOLI Thiamine-binding periplasmic protein # RefSeq NP_414610 NC_000913.3 # RefSeq WP_001301364 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial solute-binding protein 1 family. {ECO 0000305}. # SUBCELLULAR LOCATION THIB_ECOLI Periplasm. # SUBUNIT The complex is composed of two ATP-binding proteins (ThiQ), two transmembrane proteins (ThiP) and a solute-binding protein (ThiB). {ECO 0000305}. # TCDB 3.A.1.19 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR01254 sfuA # TIGRFAMs TIGR01276 thiB # eggNOG COG4143 LUCA # eggNOG ENOG4105DP9 Bacteria BLAST swissprot:THIB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:THIB_ECOLI BioCyc ECOL316407:JW0067-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0067-MONOMER BioCyc EcoCyc:SFUA-MONOMER http://biocyc.org/getid?id=EcoCyc:SFUA-MONOMER COG COG1840 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1840 DIP DIP-10967N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10967N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.273.15.8946 http://dx.doi.org/10.1074/jbc.273.15.8946 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U09984 http://www.ebi.ac.uk/ena/data/view/U09984 EchoBASE EB1534 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1534 EcoGene EG11574 http://www.ecogene.org/geneInfo.php?eg_id=EG11574 EnsemblBacteria AAC73179 http://www.ensemblgenomes.org/id/AAC73179 EnsemblBacteria AAC73179 http://www.ensemblgenomes.org/id/AAC73179 EnsemblBacteria BAB96637 http://www.ensemblgenomes.org/id/BAB96637 EnsemblBacteria BAB96637 http://www.ensemblgenomes.org/id/BAB96637 EnsemblBacteria BAB96637 http://www.ensemblgenomes.org/id/BAB96637 EnsemblBacteria b0068 http://www.ensemblgenomes.org/id/b0068 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0015234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015234 GO_function GO:0030975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030975 GO_function GO:0048502 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048502 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GeneID 946306 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946306 HOGENOM HOG000272499 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000272499&db=HOGENOM6 InParanoid P31550 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31550 IntAct P31550 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31550* InterPro IPR005948 http://www.ebi.ac.uk/interpro/entry/IPR005948 InterPro IPR005967 http://www.ebi.ac.uk/interpro/entry/IPR005967 InterPro IPR006061 http://www.ebi.ac.uk/interpro/entry/IPR006061 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0067 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0067 KEGG_Gene eco:b0068 http://www.genome.jp/dbget-bin/www_bget?eco:b0068 KEGG_Orthology KO:K02064 http://www.genome.jp/dbget-bin/www_bget?KO:K02064 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA DSFSADW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DSFSADW PDB 2QRY http://www.ebi.ac.uk/pdbe-srv/view/entry/2QRY PDBsum 2QRY http://www.ebi.ac.uk/pdbsum/2QRY PROSITE PS01037 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01037 PSORT swissprot:THIB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:THIB_ECOLI PSORT-B swissprot:THIB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:THIB_ECOLI PSORT2 swissprot:THIB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:THIB_ECOLI Phobius swissprot:THIB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:THIB_ECOLI PhylomeDB P31550 http://phylomedb.org/?seqid=P31550 ProteinModelPortal P31550 http://www.proteinmodelportal.org/query/uniprot/P31550 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9535878 http://www.ncbi.nlm.nih.gov/pubmed/9535878 RefSeq NP_414610 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414610 RefSeq WP_001301364 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001301364 SMR P31550 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31550 STRING 511145.b0068 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0068&targetmode=cogs STRING COG1840 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1840&targetmode=cogs TCDB 3.A.1.19 http://www.tcdb.org/search/result.php?tc=3.A.1.19 TIGRFAMs TIGR01254 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01254 TIGRFAMs TIGR01276 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01276 UniProtKB THIB_ECOLI http://www.uniprot.org/uniprot/THIB_ECOLI UniProtKB-AC P31550 http://www.uniprot.org/uniprot/P31550 charge swissprot:THIB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:THIB_ECOLI eggNOG COG4143 http://eggnogapi.embl.de/nog_data/html/tree/COG4143 eggNOG ENOG4105DP9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DP9 epestfind swissprot:THIB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:THIB_ECOLI garnier swissprot:THIB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:THIB_ECOLI helixturnhelix swissprot:THIB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:THIB_ECOLI hmoment swissprot:THIB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:THIB_ECOLI iep swissprot:THIB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:THIB_ECOLI inforesidue swissprot:THIB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:THIB_ECOLI octanol swissprot:THIB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:THIB_ECOLI pepcoil swissprot:THIB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:THIB_ECOLI pepdigest swissprot:THIB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:THIB_ECOLI pepinfo swissprot:THIB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:THIB_ECOLI pepnet swissprot:THIB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:THIB_ECOLI pepstats swissprot:THIB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:THIB_ECOLI pepwheel swissprot:THIB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:THIB_ECOLI pepwindow swissprot:THIB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:THIB_ECOLI sigcleave swissprot:THIB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:THIB_ECOLI ## Database ID URL or Descriptions # AltName YBFL_ECOLI H repeat-associated protein in rhsC-phrB intergenic region # AltName YBFL_ECOLI ORF-H2 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG13417 ybfL # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # IntAct P75741 7 # InterPro IPR002559 Transposase_11 # InterPro IPR032806 YbfD_N # Organism YBFL_ECOLI Escherichia coli (strain K12) # PIR H64805 H64805 # Pfam PF01609 DDE_Tnp_1 # Pfam PF13808 DDE_Tnp_1_assoc # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBFL_ECOLI Putative protein YbfL # SEQUENCE CAUTION Sequence=AAC63075.1; Type=Erroneous termination; Positions=18; Note=Translated as Gln.; Evidence={ECO:0000305}; Sequence=AP009048; Type=Erroneous termination; Positions=18; Note=Translated as Gln.; Evidence={ECO 0000305}; Sequence=U00096; Type=Erroneous termination; Positions=18; Note=Translated as Gln.; Evidence={ECO:0000305}; # SIMILARITY Belongs to the transposase 11 family. {ECO 0000305}. # eggNOG COG5433 LUCA # eggNOG ENOG410600T Bacteria BLAST swissprot:YBFL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBFL_ECOLI BioCyc EcoCyc:G6377-MONOMER http://biocyc.org/getid?id=EcoCyc:G6377-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L02373 http://www.ebi.ac.uk/ena/data/view/L02373 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3193 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3193 EcoGene EG13417 http://www.ecogene.org/geneInfo.php?eg_id=EG13417 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 HOGENOM HOG000042098 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000042098&db=HOGENOM6 InParanoid P75741 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75741 IntAct P75741 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75741* InterPro IPR002559 http://www.ebi.ac.uk/interpro/entry/IPR002559 InterPro IPR032806 http://www.ebi.ac.uk/interpro/entry/IPR032806 OMA NIIMVES http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NIIMVES PSORT swissprot:YBFL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBFL_ECOLI PSORT-B swissprot:YBFL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBFL_ECOLI PSORT2 swissprot:YBFL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBFL_ECOLI Pfam PF01609 http://pfam.xfam.org/family/PF01609 Pfam PF13808 http://pfam.xfam.org/family/PF13808 Phobius swissprot:YBFL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBFL_ECOLI ProteinModelPortal P75741 http://www.proteinmodelportal.org/query/uniprot/P75741 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8387990 http://www.ncbi.nlm.nih.gov/pubmed/8387990 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SMR P75741 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75741 STRING 511145.b3484 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3484&targetmode=cogs UniProtKB YBFL_ECOLI http://www.uniprot.org/uniprot/YBFL_ECOLI UniProtKB-AC P75741 http://www.uniprot.org/uniprot/P75741 charge swissprot:YBFL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBFL_ECOLI eggNOG COG5433 http://eggnogapi.embl.de/nog_data/html/tree/COG5433 eggNOG ENOG410600T http://eggnogapi.embl.de/nog_data/html/tree/ENOG410600T epestfind swissprot:YBFL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBFL_ECOLI garnier swissprot:YBFL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBFL_ECOLI helixturnhelix swissprot:YBFL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBFL_ECOLI hmoment swissprot:YBFL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBFL_ECOLI iep swissprot:YBFL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBFL_ECOLI inforesidue swissprot:YBFL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBFL_ECOLI octanol swissprot:YBFL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBFL_ECOLI pepcoil swissprot:YBFL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBFL_ECOLI pepdigest swissprot:YBFL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBFL_ECOLI pepinfo swissprot:YBFL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBFL_ECOLI pepnet swissprot:YBFL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBFL_ECOLI pepstats swissprot:YBFL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBFL_ECOLI pepwheel swissprot:YBFL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBFL_ECOLI pepwindow swissprot:YBFL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBFL_ECOLI sigcleave swissprot:YBFL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBFL_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES AMN_ECOLI Kinetic parameters KM=15 mM for AMP (in the absence of Mg-ATP) {ECO 0000269|PubMed 7000783}; KM=0.09 mM for AMP (in the presence of saturating Mg-ATP) {ECO 0000269|PubMed 7000783}; # BioGrid 4260401 9 # CATALYTIC ACTIVITY AMN_ECOLI AMP + H(2)O = D-ribose 5-phosphate + adenine. {ECO 0000255|HAMAP-Rule MF_01932, ECO 0000269|PubMed 7000783}. # DISRUPTION PHENOTYPE Knockout elevates intracellular ATP levels and increases cold tolerance. {ECO:0000269|PubMed 18029299}. # DOMAIN AMN_ECOLI Each monomer consists of two domains a C-terminal catalytic domain and a putative N-terminal regulatory domain. {ECO 0000269|PubMed 15296732}. # ENZYME REGULATION Allosterically activated by Mg-ATP. Inhibited by inorganic phosphate and formycin monophosphate. {ECO:0000269|PubMed 7000783}. # EcoGene EG10039 amn # FUNCTION AMN_ECOLI Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations. {ECO 0000255|HAMAP-Rule MF_01932, ECO 0000269|PubMed 7000783}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008714 AMP nucleosidase activity; IDA:EcoCyc. # GO_process GO:0044209 AMP salvage; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.30.1730.10 -; 1. # Gene3D 3.40.50.1580 -; 1. # HAMAP MF_01932 AMP_nucleosidase # INDUCTION By cAMP at limiting phosphate concentrations. Repressed by phosphate. {ECO:0000269|PubMed 2690948}. # IntAct P0AE12 8 # InterPro IPR000845 Nucleoside_phosphorylase_d # InterPro IPR011271 AMP_nucleosidase # InterPro IPR018017 Nucleoside_phosphorylase # InterPro IPR018953 AMP_nucleoside_Pase_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # MISCELLANEOUS AMP nucleosidase binds AMP at the catalytic site, Mg-ATP at an allosteric regulatory site, and inorganic phosphate also at a regulatory site. {ECO:0000303|PubMed 2690948}. # Organism AMN_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21234 PTHR21234; 2 # PATRIC 32119295 VBIEscCol129921_2060 # PDB 1T8R X-ray; 2.70 A; A/B/C/D/E/F=1-484 # PDB 1T8S X-ray; 2.60 A; A/B/C/D/E/F=1-484 # PDB 1T8W X-ray; 2.80 A; A/B/C/D/E/F=1-484 # PDB 1T8Y X-ray; 3.00 A; A/B/C/D/E/F=1-484 # PIR H64962 H64962 # Pfam PF01048 PNP_UDP_1 # Pfam PF10423 AMNp_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AMN_ECOLI AMP nucleosidase {ECO 0000255|HAMAP-Rule MF_01932, ECO 0000303|PubMed 7000783} # RefSeq NP_416489 NC_000913.3 # RefSeq WP_001060244 NZ_LN832404.1 # SIMILARITY Belongs to the AMP nucleosidase family. {ECO:0000255|HAMAP-Rule MF_01932, ECO:0000305}. # SUBUNIT Homohexamer. Trimer of dimers. {ECO:0000269|PubMed 15296732}. # SUPFAM SSF53167 SSF53167 # TIGRFAMs TIGR01717 AMP-nucleosdse # eggNOG COG0775 LUCA # eggNOG ENOG4105FYV Bacteria BLAST swissprot:AMN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AMN_ECOLI BioCyc ECOL316407:JW1963-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1963-MONOMER BioCyc EcoCyc:AMP-NUCLEOSID-MONOMER http://biocyc.org/getid?id=EcoCyc:AMP-NUCLEOSID-MONOMER BioCyc MetaCyc:AMP-NUCLEOSID-MONOMER http://biocyc.org/getid?id=MetaCyc:AMP-NUCLEOSID-MONOMER COG COG0775 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0775 DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/S0378-1119(98)00043-2 http://dx.doi.org/10.1016/S0378-1119(98)00043-2 DOI 10.1016/j.str.2004.05.015 http://dx.doi.org/10.1016/j.str.2004.05.015 DOI 10.1021/bi00448a008 http://dx.doi.org/10.1021/bi00448a008 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1098/rsbl.2007.0432 http://dx.doi.org/10.1098/rsbl.2007.0432 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.2.2.4 {ECO:0000255|HAMAP-Rule:MF_01932, ECO:0000269|PubMed:7000783} http://www.genome.jp/dbget-bin/www_bget?EC:3.2.2.4 {ECO:0000255|HAMAP-Rule:MF_01932, ECO:0000269|PubMed:7000783} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M30469 http://www.ebi.ac.uk/ena/data/view/M30469 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U88529 http://www.ebi.ac.uk/ena/data/view/U88529 ENZYME 3.2.2.4 {ECO:0000255|HAMAP-Rule:MF_01932, ECO:0000269|PubMed:7000783} http://enzyme.expasy.org/EC/3.2.2.4 {ECO:0000255|HAMAP-Rule:MF_01932, ECO:0000269|PubMed:7000783} EchoBASE EB0037 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0037 EcoGene EG10039 http://www.ecogene.org/geneInfo.php?eg_id=EG10039 EnsemblBacteria AAC75046 http://www.ensemblgenomes.org/id/AAC75046 EnsemblBacteria AAC75046 http://www.ensemblgenomes.org/id/AAC75046 EnsemblBacteria BAA15802 http://www.ensemblgenomes.org/id/BAA15802 EnsemblBacteria BAA15802 http://www.ensemblgenomes.org/id/BAA15802 EnsemblBacteria BAA15802 http://www.ensemblgenomes.org/id/BAA15802 EnsemblBacteria b1982 http://www.ensemblgenomes.org/id/b1982 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008714 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008714 GO_process GO:0044209 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044209 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.30.1730.10 http://www.cathdb.info/version/latest/superfamily/3.30.1730.10 Gene3D 3.40.50.1580 http://www.cathdb.info/version/latest/superfamily/3.40.50.1580 GeneID 946508 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946508 HAMAP MF_01932 http://hamap.expasy.org/unirule/MF_01932 HOGENOM HOG000156781 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000156781&db=HOGENOM6 InParanoid P0AE12 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AE12 IntAct P0AE12 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AE12* IntEnz 3.2.2.4 {ECO:0000255|HAMAP-Rule:MF_01932, ECO:0000269|PubMed:7000783} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.2.2.4 {ECO:0000255|HAMAP-Rule:MF_01932, ECO:0000269|PubMed:7000783} InterPro IPR000845 http://www.ebi.ac.uk/interpro/entry/IPR000845 InterPro IPR011271 http://www.ebi.ac.uk/interpro/entry/IPR011271 InterPro IPR018017 http://www.ebi.ac.uk/interpro/entry/IPR018017 InterPro IPR018953 http://www.ebi.ac.uk/interpro/entry/IPR018953 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1963 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1963 KEGG_Gene eco:b1982 http://www.genome.jp/dbget-bin/www_bget?eco:b1982 KEGG_Orthology KO:K01241 http://www.genome.jp/dbget-bin/www_bget?KO:K01241 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Reaction rn:R00182 http://www.genome.jp/dbget-bin/www_bget?rn:R00182 OMA CYPFVRV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CYPFVRV PANTHER PTHR21234 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21234 PDB 1T8R http://www.ebi.ac.uk/pdbe-srv/view/entry/1T8R PDB 1T8S http://www.ebi.ac.uk/pdbe-srv/view/entry/1T8S PDB 1T8W http://www.ebi.ac.uk/pdbe-srv/view/entry/1T8W PDB 1T8Y http://www.ebi.ac.uk/pdbe-srv/view/entry/1T8Y PDBsum 1T8R http://www.ebi.ac.uk/pdbsum/1T8R PDBsum 1T8S http://www.ebi.ac.uk/pdbsum/1T8S PDBsum 1T8W http://www.ebi.ac.uk/pdbsum/1T8W PDBsum 1T8Y http://www.ebi.ac.uk/pdbsum/1T8Y PSORT swissprot:AMN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AMN_ECOLI PSORT-B swissprot:AMN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AMN_ECOLI PSORT2 swissprot:AMN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AMN_ECOLI Pfam PF01048 http://pfam.xfam.org/family/PF01048 Pfam PF10423 http://pfam.xfam.org/family/PF10423 Phobius swissprot:AMN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AMN_ECOLI PhylomeDB P0AE12 http://phylomedb.org/?seqid=P0AE12 ProteinModelPortal P0AE12 http://www.proteinmodelportal.org/query/uniprot/P0AE12 PubMed 15296732 http://www.ncbi.nlm.nih.gov/pubmed/15296732 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18029299 http://www.ncbi.nlm.nih.gov/pubmed/18029299 PubMed 2690948 http://www.ncbi.nlm.nih.gov/pubmed/2690948 PubMed 7000783 http://www.ncbi.nlm.nih.gov/pubmed/7000783 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9524262 http://www.ncbi.nlm.nih.gov/pubmed/9524262 RefSeq NP_416489 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416489 RefSeq WP_001060244 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001060244 SMR P0AE12 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AE12 STRING 511145.b1982 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1982&targetmode=cogs STRING COG0775 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0775&targetmode=cogs SUPFAM SSF53167 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53167 TIGRFAMs TIGR01717 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01717 UniProtKB AMN_ECOLI http://www.uniprot.org/uniprot/AMN_ECOLI UniProtKB-AC P0AE12 http://www.uniprot.org/uniprot/P0AE12 charge swissprot:AMN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AMN_ECOLI eggNOG COG0775 http://eggnogapi.embl.de/nog_data/html/tree/COG0775 eggNOG ENOG4105FYV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FYV epestfind swissprot:AMN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AMN_ECOLI garnier swissprot:AMN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AMN_ECOLI helixturnhelix swissprot:AMN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AMN_ECOLI hmoment swissprot:AMN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AMN_ECOLI iep swissprot:AMN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AMN_ECOLI inforesidue swissprot:AMN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AMN_ECOLI octanol swissprot:AMN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AMN_ECOLI pepcoil swissprot:AMN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AMN_ECOLI pepdigest swissprot:AMN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AMN_ECOLI pepinfo swissprot:AMN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AMN_ECOLI pepnet swissprot:AMN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AMN_ECOLI pepstats swissprot:AMN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AMN_ECOLI pepwheel swissprot:AMN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AMN_ECOLI pepwindow swissprot:AMN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AMN_ECOLI sigcleave swissprot:AMN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AMN_ECOLI ## Database ID URL or Descriptions # BioGrid 4262514 141 # EcoGene EG12224 yhiI # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_process GO:0009306 protein secretion; IEA:InterPro. # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006810 transport # InterPro IPR003997 Rtx_secretion_protD_GmN_bac # Organism YHII_ECOLI Escherichia coli (strain K12) # PATRIC 32122418 VBIEscCol129921_3586 # PIR S47707 S47707 # PRINTS PR01490 RTXTOXIND # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHII_ECOLI Uncharacterized protein YhiI # RefSeq NP_417944 NC_000913.3 # RefSeq WP_000361477 NZ_LN832404.1 # TCDB 3.A.1.105.16 the atp-binding cassette (abc) superfamily # eggNOG ENOG4105D0S Bacteria # eggNOG ENOG410XPU6 LUCA BLAST swissprot:YHII_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHII_ECOLI BioCyc ECOL316407:JW3454-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3454-MONOMER BioCyc EcoCyc:EG12224-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12224-MONOMER COG COG0845 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0845 DIP DIP-12364N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12364N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2137 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2137 EcoGene EG12224 http://www.ecogene.org/geneInfo.php?eg_id=EG12224 EnsemblBacteria AAC76512 http://www.ensemblgenomes.org/id/AAC76512 EnsemblBacteria AAC76512 http://www.ensemblgenomes.org/id/AAC76512 EnsemblBacteria BAE77806 http://www.ensemblgenomes.org/id/BAE77806 EnsemblBacteria BAE77806 http://www.ensemblgenomes.org/id/BAE77806 EnsemblBacteria BAE77806 http://www.ensemblgenomes.org/id/BAE77806 EnsemblBacteria b3487 http://www.ensemblgenomes.org/id/b3487 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_process GO:0009306 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009306 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948003 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948003 HOGENOM HOG000125792 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125792&db=HOGENOM6 InParanoid P37626 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37626 IntAct P37626 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37626* InterPro IPR003997 http://www.ebi.ac.uk/interpro/entry/IPR003997 KEGG_Gene ecj:JW3454 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3454 KEGG_Gene eco:b3487 http://www.genome.jp/dbget-bin/www_bget?eco:b3487 KEGG_Orthology KO:K01993 http://www.genome.jp/dbget-bin/www_bget?KO:K01993 OMA PRLSNQL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PRLSNQL PRINTS PR01490 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01490 PSORT swissprot:YHII_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHII_ECOLI PSORT-B swissprot:YHII_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHII_ECOLI PSORT2 swissprot:YHII_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHII_ECOLI Phobius swissprot:YHII_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHII_ECOLI PhylomeDB P37626 http://phylomedb.org/?seqid=P37626 ProteinModelPortal P37626 http://www.proteinmodelportal.org/query/uniprot/P37626 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417944 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417944 RefSeq WP_000361477 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000361477 SMR P37626 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37626 STRING 511145.b3487 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3487&targetmode=cogs STRING COG0845 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0845&targetmode=cogs TCDB 3.A.1.105.16 http://www.tcdb.org/search/result.php?tc=3.A.1.105.16 UniProtKB YHII_ECOLI http://www.uniprot.org/uniprot/YHII_ECOLI UniProtKB-AC P37626 http://www.uniprot.org/uniprot/P37626 charge swissprot:YHII_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHII_ECOLI eggNOG ENOG4105D0S http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D0S eggNOG ENOG410XPU6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPU6 epestfind swissprot:YHII_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHII_ECOLI garnier swissprot:YHII_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHII_ECOLI helixturnhelix swissprot:YHII_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHII_ECOLI hmoment swissprot:YHII_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHII_ECOLI iep swissprot:YHII_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHII_ECOLI inforesidue swissprot:YHII_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHII_ECOLI octanol swissprot:YHII_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHII_ECOLI pepcoil swissprot:YHII_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHII_ECOLI pepdigest swissprot:YHII_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHII_ECOLI pepinfo swissprot:YHII_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHII_ECOLI pepnet swissprot:YHII_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHII_ECOLI pepstats swissprot:YHII_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHII_ECOLI pepwheel swissprot:YHII_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHII_ECOLI pepwindow swissprot:YHII_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHII_ECOLI sigcleave swissprot:YHII_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHII_ECOLI ## Database ID URL or Descriptions # BioGrid 4262019 2 # CATALYTIC ACTIVITY ATP + methylphosphonate = alpha-D-ribose 1- methylphosphonate 5-triphosphate + adenine. {ECO:0000269|PubMed 22089136}. # EcoGene EG10721 phnL # FUNCTION PHNL_ECOLI Together with PhnG, PhnH and PhnI is required for the transfer of the ribose triphosphate moiety from ATP to methyl phosphonate. {ECO 0000269|PubMed 22089136}. # GO_component GO:0061694 alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase complex; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016887 ATPase activity; IEA:InterPro. # GO_function GO:0061693 alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity; IEA:UniProtKB-EC. # GO_process GO:0019700 organic phosphonate catabolic process; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # Gene3D 3.40.50.300 -; 1. # IntAct P16679 4 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR012701 CP_lyase_PhnL # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00224 Putative phosphonate transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism PHNL_ECOLI Escherichia coli (strain K12) # PATRIC 32123751 VBIEscCol129921_4224 # PIR D35719 D35719 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # Pfam PF00005 ABC_tran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PHNL_ECOLI Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnL # RefSeq NP_418520 NC_000913.3 # RefSeq WP_000611405 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR02324 CP_lyasePhnL # eggNOG COG4778 LUCA # eggNOG ENOG4105HRV Bacteria BLAST swissprot:PHNL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PHNL_ECOLI BioCyc ECOL316407:JW4057-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4057-MONOMER BioCyc EcoCyc:PHNL-MONOMER http://biocyc.org/getid?id=EcoCyc:PHNL-MONOMER BioCyc MetaCyc:PHNL-MONOMER http://biocyc.org/getid?id=MetaCyc:PHNL-MONOMER COG COG4778 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4778 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature10622 http://dx.doi.org/10.1038/nature10622 DOI 10.1073/pnas.1104922108 http://dx.doi.org/10.1073/pnas.1104922108 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.8.37 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.8.37 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D90227 http://www.ebi.ac.uk/ena/data/view/D90227 EMBL J05260 http://www.ebi.ac.uk/ena/data/view/J05260 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 2.7.8.37 http://enzyme.expasy.org/EC/2.7.8.37 EchoBASE EB0715 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0715 EcoGene EG10721 http://www.ecogene.org/geneInfo.php?eg_id=EG10721 EnsemblBacteria AAC77057 http://www.ensemblgenomes.org/id/AAC77057 EnsemblBacteria AAC77057 http://www.ensemblgenomes.org/id/AAC77057 EnsemblBacteria BAE78099 http://www.ensemblgenomes.org/id/BAE78099 EnsemblBacteria BAE78099 http://www.ensemblgenomes.org/id/BAE78099 EnsemblBacteria BAE78099 http://www.ensemblgenomes.org/id/BAE78099 EnsemblBacteria b4096 http://www.ensemblgenomes.org/id/b4096 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0061694 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061694 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_function GO:0061693 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061693 GO_process GO:0019700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019700 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948612 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948612 InParanoid P16679 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P16679 IntAct P16679 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P16679* IntEnz 2.7.8.37 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.8.37 InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR012701 http://www.ebi.ac.uk/interpro/entry/IPR012701 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW4057 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4057 KEGG_Gene eco:b4096 http://www.genome.jp/dbget-bin/www_bget?eco:b4096 KEGG_Orthology KO:K05780 http://www.genome.jp/dbget-bin/www_bget?KO:K05780 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA KMIYGNY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KMIYGNY PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:PHNL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PHNL_ECOLI PSORT-B swissprot:PHNL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PHNL_ECOLI PSORT2 swissprot:PHNL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PHNL_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Phobius swissprot:PHNL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PHNL_ECOLI PhylomeDB P16679 http://phylomedb.org/?seqid=P16679 ProteinModelPortal P16679 http://www.proteinmodelportal.org/query/uniprot/P16679 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1840580 http://www.ncbi.nlm.nih.gov/pubmed/1840580 PubMed 2155230 http://www.ncbi.nlm.nih.gov/pubmed/2155230 PubMed 21705661 http://www.ncbi.nlm.nih.gov/pubmed/21705661 PubMed 22089136 http://www.ncbi.nlm.nih.gov/pubmed/22089136 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418520 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418520 RefSeq WP_000611405 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000611405 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P16679 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P16679 STRING 511145.b4096 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4096&targetmode=cogs STRING COG4778 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4778&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR02324 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02324 UniProtKB PHNL_ECOLI http://www.uniprot.org/uniprot/PHNL_ECOLI UniProtKB-AC P16679 http://www.uniprot.org/uniprot/P16679 charge swissprot:PHNL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PHNL_ECOLI eggNOG COG4778 http://eggnogapi.embl.de/nog_data/html/tree/COG4778 eggNOG ENOG4105HRV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105HRV epestfind swissprot:PHNL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PHNL_ECOLI garnier swissprot:PHNL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PHNL_ECOLI helixturnhelix swissprot:PHNL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PHNL_ECOLI hmoment swissprot:PHNL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PHNL_ECOLI iep swissprot:PHNL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PHNL_ECOLI inforesidue swissprot:PHNL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PHNL_ECOLI octanol swissprot:PHNL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PHNL_ECOLI pepcoil swissprot:PHNL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PHNL_ECOLI pepdigest swissprot:PHNL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PHNL_ECOLI pepinfo swissprot:PHNL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PHNL_ECOLI pepnet swissprot:PHNL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PHNL_ECOLI pepstats swissprot:PHNL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PHNL_ECOLI pepwheel swissprot:PHNL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PHNL_ECOLI pepwindow swissprot:PHNL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PHNL_ECOLI sigcleave swissprot:PHNL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PHNL_ECOLI ## Database ID URL or Descriptions # AltName KPYK2_ECOLI PK-2 # BioGrid 4263205 9 # CATALYTIC ACTIVITY KPYK2_ECOLI ATP + pyruvate = ADP + phosphoenolpyruvate. # COFACTOR Name=K(+); Xref=ChEBI:CHEBI 29103; # COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI 18420; # ENZYME REGULATION KPYK2_ECOLI Allosterically activated by AMP and by several sugar phosphates. Belongs to type II PK. # EcoGene EG10803 pykA # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0000287 magnesium ion binding; IEA:InterPro. # GO_function GO:0004743 pyruvate kinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016301 kinase activity; IEA:UniProtKB-KW. # GO_function GO:0030955 potassium ion binding; IEA:InterPro. # GO_function GO:0042802 identical protein binding; IPI:EcoCyc. # GO_process GO:0051289 protein homotetramerization; IPI:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006461 protein complex assembly # Gene3D 2.40.33.10 -; 1. # Gene3D 3.20.20.60 -; 2. # Gene3D 3.40.1380.20 -; 1. # INTERACTION KPYK2_ECOLI Self; NbExp=3; IntAct=EBI-368956, EBI-368956; P19642 malX; NbExp=3; IntAct=EBI-368956, EBI-556578; P52052 yggR; NbExp=3; IntAct=EBI-368956, EBI-552531; # IntAct P21599 15 # InterPro IPR001697 Pyr_Knase # InterPro IPR011037 Pyrv_Knase-like_insert_dom # InterPro IPR015793 Pyrv_Knase_brl # InterPro IPR015794 Pyrv_Knase_a/b # InterPro IPR015795 Pyrv_Knase_C # InterPro IPR015806 Pyrv_Knase_insert_dom # InterPro IPR015813 Pyrv/PenolPyrv_Kinase-like_dom # InterPro IPR018209 Pyrv_Knase_AS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00010 Glycolysis / Gluconeogenesis # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00620 Pyruvate metabolism # KEGG_Pathway ko00710 Carbon fixation in photosynthetic organisms # KEGG_Pathway ko04930 Type II diabetes mellitus # KEGG_Pathway ko05203 Viral carcinogenesis # Organism KPYK2_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11817 PTHR11817 # PATHWAY Carbohydrate degradation; glycolysis; pyruvate from D- glyceraldehyde 3-phosphate step 5/5. # PATRIC 32119031 VBIEscCol129921_1933 # PIR S29790 S29790 # PRINTS PR01050 PYRUVTKNASE # PROSITE PS00110 PYRUVATE_KINASE # Pfam PF00224 PK # Pfam PF02887 PK_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName KPYK2_ECOLI Pyruvate kinase II # RefSeq NP_416368 NC_000913.3 # RefSeq WP_000091148 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA96707.1; Type=Frameshift; Positions=441; Evidence={ECO 0000305}; # SIMILARITY Belongs to the pyruvate kinase family. {ECO 0000305}. # SUBUNIT KPYK2_ECOLI Homotetramer. # SUPFAM SSF50800 SSF50800 # SUPFAM SSF51621 SSF51621; 2 # SUPFAM SSF52935 SSF52935 # TIGRFAMs TIGR01064 pyruv_kin # UniPathway UPA00109 UER00188 # eggNOG COG0469 LUCA # eggNOG ENOG4105CA9 Bacteria BLAST swissprot:KPYK2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:KPYK2_ECOLI BioCyc ECOL316407:JW1843-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1843-MONOMER BioCyc EcoCyc:PKII-MONOMER http://biocyc.org/getid?id=EcoCyc:PKII-MONOMER BioCyc MetaCyc:PKII-MONOMER http://biocyc.org/getid?id=MetaCyc:PKII-MONOMER COG COG0469 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0469 DIP DIP-10622N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10622N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.40 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.40 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M63703 http://www.ebi.ac.uk/ena/data/view/M63703 EMBL M77039 http://www.ebi.ac.uk/ena/data/view/M77039 EMBL M87660 http://www.ebi.ac.uk/ena/data/view/M87660 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.40 http://enzyme.expasy.org/EC/2.7.1.40 EchoBASE EB0796 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0796 EcoGene EG10803 http://www.ecogene.org/geneInfo.php?eg_id=EG10803 EnsemblBacteria AAC74924 http://www.ensemblgenomes.org/id/AAC74924 EnsemblBacteria AAC74924 http://www.ensemblgenomes.org/id/AAC74924 EnsemblBacteria BAA15662 http://www.ensemblgenomes.org/id/BAA15662 EnsemblBacteria BAA15662 http://www.ensemblgenomes.org/id/BAA15662 EnsemblBacteria BAA15662 http://www.ensemblgenomes.org/id/BAA15662 EnsemblBacteria b1854 http://www.ensemblgenomes.org/id/b1854 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0004743 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004743 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_function GO:0030955 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030955 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0051289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051289 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 Gene3D 2.40.33.10 http://www.cathdb.info/version/latest/superfamily/2.40.33.10 Gene3D 3.20.20.60 http://www.cathdb.info/version/latest/superfamily/3.20.20.60 Gene3D 3.40.1380.20 http://www.cathdb.info/version/latest/superfamily/3.40.1380.20 GeneID 946527 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946527 HOGENOM HOG000021558 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000021558&db=HOGENOM6 InParanoid P21599 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P21599 IntAct P21599 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P21599* IntEnz 2.7.1.40 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.40 InterPro IPR001697 http://www.ebi.ac.uk/interpro/entry/IPR001697 InterPro IPR011037 http://www.ebi.ac.uk/interpro/entry/IPR011037 InterPro IPR015793 http://www.ebi.ac.uk/interpro/entry/IPR015793 InterPro IPR015794 http://www.ebi.ac.uk/interpro/entry/IPR015794 InterPro IPR015795 http://www.ebi.ac.uk/interpro/entry/IPR015795 InterPro IPR015806 http://www.ebi.ac.uk/interpro/entry/IPR015806 InterPro IPR015813 http://www.ebi.ac.uk/interpro/entry/IPR015813 InterPro IPR018209 http://www.ebi.ac.uk/interpro/entry/IPR018209 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1843 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1843 KEGG_Gene eco:b1854 http://www.genome.jp/dbget-bin/www_bget?eco:b1854 KEGG_Orthology KO:K00873 http://www.genome.jp/dbget-bin/www_bget?KO:K00873 KEGG_Pathway ko00010 http://www.genome.jp/kegg-bin/show_pathway?ko00010 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00620 http://www.genome.jp/kegg-bin/show_pathway?ko00620 KEGG_Pathway ko00710 http://www.genome.jp/kegg-bin/show_pathway?ko00710 KEGG_Pathway ko04930 http://www.genome.jp/kegg-bin/show_pathway?ko04930 KEGG_Pathway ko05203 http://www.genome.jp/kegg-bin/show_pathway?ko05203 KEGG_Reaction rn:R00200 http://www.genome.jp/dbget-bin/www_bget?rn:R00200 KEGG_Reaction rn:R00430 http://www.genome.jp/dbget-bin/www_bget?rn:R00430 KEGG_Reaction rn:R01138 http://www.genome.jp/dbget-bin/www_bget?rn:R01138 KEGG_Reaction rn:R01858 http://www.genome.jp/dbget-bin/www_bget?rn:R01858 KEGG_Reaction rn:R02320 http://www.genome.jp/dbget-bin/www_bget?rn:R02320 MINT MINT-1238649 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1238649 OMA ANHMEGV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ANHMEGV PANTHER PTHR11817 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11817 PRINTS PR01050 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01050 PROSITE PS00110 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00110 PSORT swissprot:KPYK2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:KPYK2_ECOLI PSORT-B swissprot:KPYK2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:KPYK2_ECOLI PSORT2 swissprot:KPYK2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:KPYK2_ECOLI Pfam PF00224 http://pfam.xfam.org/family/PF00224 Pfam PF02887 http://pfam.xfam.org/family/PF02887 Phobius swissprot:KPYK2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:KPYK2_ECOLI PhylomeDB P21599 http://phylomedb.org/?seqid=P21599 ProteinModelPortal P21599 http://www.proteinmodelportal.org/query/uniprot/P21599 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1732206 http://www.ncbi.nlm.nih.gov/pubmed/1732206 PubMed 1859631 http://www.ncbi.nlm.nih.gov/pubmed/1859631 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 8439398 http://www.ncbi.nlm.nih.gov/pubmed/8439398 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416368 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416368 RefSeq WP_000091148 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000091148 SMR P21599 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P21599 STRING 511145.b1854 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1854&targetmode=cogs STRING COG0469 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0469&targetmode=cogs SUPFAM SSF50800 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50800 SUPFAM SSF51621 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51621 SUPFAM SSF52935 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52935 TIGRFAMs TIGR01064 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01064 UniProtKB KPYK2_ECOLI http://www.uniprot.org/uniprot/KPYK2_ECOLI UniProtKB-AC P21599 http://www.uniprot.org/uniprot/P21599 charge swissprot:KPYK2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:KPYK2_ECOLI eggNOG COG0469 http://eggnogapi.embl.de/nog_data/html/tree/COG0469 eggNOG ENOG4105CA9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CA9 epestfind swissprot:KPYK2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:KPYK2_ECOLI garnier swissprot:KPYK2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:KPYK2_ECOLI helixturnhelix swissprot:KPYK2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:KPYK2_ECOLI hmoment swissprot:KPYK2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:KPYK2_ECOLI iep swissprot:KPYK2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:KPYK2_ECOLI inforesidue swissprot:KPYK2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:KPYK2_ECOLI octanol swissprot:KPYK2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:KPYK2_ECOLI pepcoil swissprot:KPYK2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:KPYK2_ECOLI pepdigest swissprot:KPYK2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:KPYK2_ECOLI pepinfo swissprot:KPYK2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:KPYK2_ECOLI pepnet swissprot:KPYK2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:KPYK2_ECOLI pepstats swissprot:KPYK2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:KPYK2_ECOLI pepwheel swissprot:KPYK2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:KPYK2_ECOLI pepwindow swissprot:KPYK2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:KPYK2_ECOLI sigcleave swissprot:KPYK2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:KPYK2_ECOLI ## Database ID URL or Descriptions # BRENDA 2.7.7.73 2026 # BioGrid 4262657 10 # CATALYTIC ACTIVITY ATP + [ThiS] = diphosphate + adenylyl-[ThiS]. {ECO:0000269|PubMed 9632726}. # COFACTOR THIF_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 15896804, ECO 0000269|PubMed 16388576}; Note=Binds 1 zinc ion per subunit. {ECO 0000269|PubMed 15896804, ECO 0000269|PubMed 16388576}; # EcoGene EG11587 thiF # FUNCTION THIF_ECOLI Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein ThiS. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_function GO:0008641 small protein activating enzyme activity; IEA:InterPro. # GO_function GO:0016779 nucleotidyltransferase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IDA:EcoCyc. # GO_process GO:0006464 cellular protein modification process; IBA:GO_Central. # GO_process GO:0009228 thiamine biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0009229 thiamine diphosphate biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.720 -; 1. # IntAct P30138 8 # InterPro IPR000594 ThiF_NAD_FAD-bd # InterPro IPR012731 Adenyl_ThiF # InterPro IPR016040 NAD(P)-bd_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00730 Thiamine metabolism # KEGG_Pathway ko04122 Sulfur relay system # MASS SPECTROMETRY Mass=26970.2; Method=Electrospray; Range=1-251; Evidence={ECO:0000269|PubMed 10082377}; # Organism THIF_ECOLI Escherichia coli (strain K12) # PATHWAY THIF_ECOLI Cofactor biosynthesis; thiamine diphosphate biosynthesis. # PATRIC 32123507 VBIEscCol129921_4106 # PDB 1ZFN X-ray; 2.75 A; A/B/C/D=1-251 # PDB 1ZKM X-ray; 2.95 A; A/B/C/D=1-251 # PDB 1ZUD X-ray; 1.98 A; 1/3=1-251 # PIR C65206 C65206 # Pfam PF00899 ThiF # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName THIF_ECOLI Sulfur carrier protein ThiS adenylyltransferase # RefSeq NP_418420 NC_000913.3 # RefSeq WP_000999737 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAC43090.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the HesA/MoeB/ThiF family. {ECO 0000305}. # SUBUNIT THIF_ECOLI Homodimer. {ECO 0000269|PubMed 15896804, ECO 0000269|PubMed 16388576}. # SUPFAM SSF69572 SSF69572 # TIGRFAMs TIGR02356 adenyl_thiF # eggNOG COG0476 LUCA # eggNOG ENOG4105D06 Bacteria BLAST swissprot:THIF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:THIF_ECOLI BioCyc ECOL316407:JW3956-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3956-MONOMER BioCyc EcoCyc:THIF-MONOMER http://biocyc.org/getid?id=EcoCyc:THIF-MONOMER BioCyc MetaCyc:THIF-MONOMER http://biocyc.org/getid?id=MetaCyc:THIF-MONOMER COG COG0476 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0476 DOI 10.1002/pro.5560070815 http://dx.doi.org/10.1002/pro.5560070815 DOI 10.1016/j.jmb.2005.04.011 http://dx.doi.org/10.1016/j.jmb.2005.04.011 DOI 10.1021/bi051502y http://dx.doi.org/10.1021/bi051502y DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.141226698 http://dx.doi.org/10.1073/pnas.141226698 DOI 10.1074/jbc.273.26.16555 http://dx.doi.org/10.1074/jbc.273.26.16555 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.7.73 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.73 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M88701 http://www.ebi.ac.uk/ena/data/view/M88701 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.7.73 http://enzyme.expasy.org/EC/2.7.7.73 EchoBASE EB1546 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1546 EcoGene EG11587 http://www.ecogene.org/geneInfo.php?eg_id=EG11587 EnsemblBacteria AAC76966 http://www.ensemblgenomes.org/id/AAC76966 EnsemblBacteria AAC76966 http://www.ensemblgenomes.org/id/AAC76966 EnsemblBacteria BAE77327 http://www.ensemblgenomes.org/id/BAE77327 EnsemblBacteria BAE77327 http://www.ensemblgenomes.org/id/BAE77327 EnsemblBacteria BAE77327 http://www.ensemblgenomes.org/id/BAE77327 EnsemblBacteria b3992 http://www.ensemblgenomes.org/id/b3992 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0008641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008641 GO_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GO_process GO:0009228 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009228 GO_process GO:0009229 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009229 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 948500 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948500 HOGENOM HOG000281217 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000281217&db=HOGENOM6 InParanoid P30138 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30138 IntAct P30138 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P30138* IntEnz 2.7.7.73 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.73 InterPro IPR000594 http://www.ebi.ac.uk/interpro/entry/IPR000594 InterPro IPR012731 http://www.ebi.ac.uk/interpro/entry/IPR012731 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3956 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3956 KEGG_Gene eco:b3992 http://www.genome.jp/dbget-bin/www_bget?eco:b3992 KEGG_Orthology KO:K03148 http://www.genome.jp/dbget-bin/www_bget?KO:K03148 KEGG_Pathway ko00730 http://www.genome.jp/kegg-bin/show_pathway?ko00730 KEGG_Pathway ko04122 http://www.genome.jp/kegg-bin/show_pathway?ko04122 KEGG_Reaction rn:R07459 http://www.genome.jp/dbget-bin/www_bget?rn:R07459 KEGG_Reaction rn:R07462 http://www.genome.jp/dbget-bin/www_bget?rn:R07462 OMA YHCLFPF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YHCLFPF PDB 1ZFN http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZFN PDB 1ZKM http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZKM PDB 1ZUD http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZUD PDBsum 1ZFN http://www.ebi.ac.uk/pdbsum/1ZFN PDBsum 1ZKM http://www.ebi.ac.uk/pdbsum/1ZKM PDBsum 1ZUD http://www.ebi.ac.uk/pdbsum/1ZUD PSORT swissprot:THIF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:THIF_ECOLI PSORT-B swissprot:THIF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:THIF_ECOLI PSORT2 swissprot:THIF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:THIF_ECOLI Pfam PF00899 http://pfam.xfam.org/family/PF00899 Phobius swissprot:THIF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:THIF_ECOLI PhylomeDB P30138 http://phylomedb.org/?seqid=P30138 ProteinModelPortal P30138 http://www.proteinmodelportal.org/query/uniprot/P30138 PubMed 10082377 http://www.ncbi.nlm.nih.gov/pubmed/10082377 PubMed 11438688 http://www.ncbi.nlm.nih.gov/pubmed/11438688 PubMed 15896804 http://www.ncbi.nlm.nih.gov/pubmed/15896804 PubMed 16388576 http://www.ncbi.nlm.nih.gov/pubmed/16388576 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 8432721 http://www.ncbi.nlm.nih.gov/pubmed/8432721 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9632726 http://www.ncbi.nlm.nih.gov/pubmed/9632726 RefSeq NP_418420 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418420 RefSeq WP_000999737 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000999737 SMR P30138 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P30138 STRING 511145.b3992 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3992&targetmode=cogs STRING COG0476 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0476&targetmode=cogs SUPFAM SSF69572 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF69572 TIGRFAMs TIGR02356 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02356 UniProtKB THIF_ECOLI http://www.uniprot.org/uniprot/THIF_ECOLI UniProtKB-AC P30138 http://www.uniprot.org/uniprot/P30138 charge swissprot:THIF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:THIF_ECOLI eggNOG COG0476 http://eggnogapi.embl.de/nog_data/html/tree/COG0476 eggNOG ENOG4105D06 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D06 epestfind swissprot:THIF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:THIF_ECOLI garnier swissprot:THIF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:THIF_ECOLI helixturnhelix swissprot:THIF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:THIF_ECOLI hmoment swissprot:THIF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:THIF_ECOLI iep swissprot:THIF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:THIF_ECOLI inforesidue swissprot:THIF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:THIF_ECOLI octanol swissprot:THIF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:THIF_ECOLI pepcoil swissprot:THIF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:THIF_ECOLI pepdigest swissprot:THIF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:THIF_ECOLI pepinfo swissprot:THIF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:THIF_ECOLI pepnet swissprot:THIF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:THIF_ECOLI pepstats swissprot:THIF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:THIF_ECOLI pepwheel swissprot:THIF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:THIF_ECOLI pepwindow swissprot:THIF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:THIF_ECOLI sigcleave swissprot:THIF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:THIF_ECOLI ## Database ID URL or Descriptions # BioGrid 4262924 129 # EcoGene EG12218 dcrB # FUNCTION DCRB_ECOLI Required for phage C1 adsorption. # GO_component GO:0042597 periplasmic space; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # Gene3D 3.40.1000.10 -; 1. # IntAct P0AEE1 9 # InterPro IPR014894 DcrB # InterPro IPR016123 Mog1/PsbP_a/b/a-sand # MISCELLANEOUS DCRB_ECOLI May interact with SdaC for phage adsorption. # Organism DCRB_ECOLI Escherichia coli (strain K12) # PATRIC 32122388 VBIEscCol129921_3571 # Pfam PF08786 DUF1795 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DCRB_ECOLI Protein DcrB # RefSeq NP_417929 NC_000913.3 # RefSeq WP_001245295 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18447.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SUBCELLULAR LOCATION DCRB_ECOLI Periplasm. # eggNOG ENOG4108W1V Bacteria # eggNOG ENOG4111IIQ LUCA BLAST swissprot:DCRB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DCRB_ECOLI BioCyc ECOL316407:JW5682-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5682-MONOMER BioCyc EcoCyc:G7767-MONOMER http://biocyc.org/getid?id=EcoCyc:G7767-MONOMER DIP DIP-36187N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36187N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2132 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2132 EcoGene EG12218 http://www.ecogene.org/geneInfo.php?eg_id=EG12218 EnsemblBacteria AAC76497 http://www.ensemblgenomes.org/id/AAC76497 EnsemblBacteria AAC76497 http://www.ensemblgenomes.org/id/AAC76497 EnsemblBacteria BAE77821 http://www.ensemblgenomes.org/id/BAE77821 EnsemblBacteria BAE77821 http://www.ensemblgenomes.org/id/BAE77821 EnsemblBacteria BAE77821 http://www.ensemblgenomes.org/id/BAE77821 EnsemblBacteria b3472 http://www.ensemblgenomes.org/id/b3472 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 Gene3D 3.40.1000.10 http://www.cathdb.info/version/latest/superfamily/3.40.1000.10 GeneID 947983 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947983 HOGENOM HOG000125708 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125708&db=HOGENOM6 InParanoid P0AEE1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEE1 IntAct P0AEE1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEE1* InterPro IPR014894 http://www.ebi.ac.uk/interpro/entry/IPR014894 InterPro IPR016123 http://www.ebi.ac.uk/interpro/entry/IPR016123 KEGG_Gene ecj:JW5682 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5682 KEGG_Gene eco:b3472 http://www.genome.jp/dbget-bin/www_bget?eco:b3472 OMA ACDNSDT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ACDNSDT PSORT swissprot:DCRB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DCRB_ECOLI PSORT-B swissprot:DCRB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DCRB_ECOLI PSORT2 swissprot:DCRB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DCRB_ECOLI Pfam PF08786 http://pfam.xfam.org/family/PF08786 Phobius swissprot:DCRB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DCRB_ECOLI ProteinModelPortal P0AEE1 http://www.proteinmodelportal.org/query/uniprot/P0AEE1 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 8752353 http://www.ncbi.nlm.nih.gov/pubmed/8752353 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417929 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417929 RefSeq WP_001245295 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001245295 SMR P0AEE1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEE1 STRING 511145.b3472 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3472&targetmode=cogs SWISS-2DPAGE P0AEE1 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AEE1 UniProtKB DCRB_ECOLI http://www.uniprot.org/uniprot/DCRB_ECOLI UniProtKB-AC P0AEE1 http://www.uniprot.org/uniprot/P0AEE1 charge swissprot:DCRB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DCRB_ECOLI eggNOG ENOG4108W1V http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108W1V eggNOG ENOG4111IIQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111IIQ epestfind swissprot:DCRB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DCRB_ECOLI garnier swissprot:DCRB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DCRB_ECOLI helixturnhelix swissprot:DCRB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DCRB_ECOLI hmoment swissprot:DCRB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DCRB_ECOLI iep swissprot:DCRB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DCRB_ECOLI inforesidue swissprot:DCRB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DCRB_ECOLI octanol swissprot:DCRB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DCRB_ECOLI pepcoil swissprot:DCRB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DCRB_ECOLI pepdigest swissprot:DCRB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DCRB_ECOLI pepinfo swissprot:DCRB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DCRB_ECOLI pepnet swissprot:DCRB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DCRB_ECOLI pepstats swissprot:DCRB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DCRB_ECOLI pepwheel swissprot:DCRB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DCRB_ECOLI pepwindow swissprot:DCRB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DCRB_ECOLI sigcleave swissprot:DCRB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DCRB_ECOLI ## Database ID URL or Descriptions # AltName tRNA [Gm18] methyltransferase {ECO:0000255|HAMAP-Rule MF_02060, ECO:0000305} # BioGrid 4262569 160 # CATALYTIC ACTIVITY TRMH_ECOLI S-adenosyl-L-methionine + guanosine(18) in tRNA = S-adenosyl-L-homocysteine + 2'-O-methylguanosine(18) in tRNA. {ECO 0000255|HAMAP-Rule MF_02060, ECO 0000269|PubMed 9321663}. # EcoGene EG10967 trmH # FUNCTION TRMH_ECOLI Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA. Type II methylase, which methylates only a subset of tRNA species. {ECO 0000269|PubMed 9321663}. # GO_function GO:0000049 tRNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0003723 RNA binding; IBA:GO_Central. # GO_function GO:0009020 tRNA (guanosine-2'-O-)-methyltransferase activity; IDA:EcoCyc. # GO_process GO:0002938 tRNA guanine ribose methylation; IMP:EcoCyc. # GO_process GO:0030488 tRNA methylation; TAS:EcoliWiki. # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0006399 tRNA metabolic process # Gene3D 3.40.1280.10 -; 1. # HAMAP MF_02060 tRNA_methyltr_TrmH # IntAct P0AGJ2 11 # InterPro IPR001537 SpoU_MeTrfase # InterPro IPR022724 rRNA_MeTrfase_SpoU_C # InterPro IPR029026 tRNA_m1G_MTases_N # InterPro IPR029028 Alpha/beta_knot_MTases # InterPro IPR033671 TrmH # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # Organism TRMH_ECOLI Escherichia coli (strain K12) # PATRIC 32122789 VBIEscCol129921_3771 # PIR JV0043 JV0043 # Pfam PF00588 SpoU_methylase # Pfam PF12105 SpoU_methylas_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName tRNA (guanosine(18)-2'-O)-methyltransferase {ECO:0000255|HAMAP-Rule MF_02060, ECO:0000305} # RefSeq NP_418108 NC_000913.3 # RefSeq WP_001070177 NZ_LN832404.1 # SIMILARITY Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. {ECO:0000255|HAMAP-Rule MF_02060}. # SUPFAM SSF75217 SSF75217 # eggNOG COG0566 LUCA # eggNOG ENOG4105FE8 Bacteria BLAST swissprot:TRMH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRMH_ECOLI BioCyc ECOL316407:JW3626-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3626-MONOMER BioCyc EcoCyc:EG10967-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10967-MONOMER BioCyc MetaCyc:EG10967-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10967-MONOMER COG COG0566 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0566 DIP DIP-35977N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35977N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5519 http://dx.doi.org/10.1093/nar/21.23.5519 DOI 10.1093/nar/25.20.4093 http://dx.doi.org/10.1093/nar/25.20.4093 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.1.34 {ECO:0000255|HAMAP-Rule:MF_02060, ECO:0000269|PubMed:9321663} http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.34 {ECO:0000255|HAMAP-Rule:MF_02060, ECO:0000269|PubMed:9321663} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M24503 http://www.ebi.ac.uk/ena/data/view/M24503 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.1.1.34 {ECO:0000255|HAMAP-Rule:MF_02060, ECO:0000269|PubMed:9321663} http://enzyme.expasy.org/EC/2.1.1.34 {ECO:0000255|HAMAP-Rule:MF_02060, ECO:0000269|PubMed:9321663} EchoBASE EB0960 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0960 EcoGene EG10967 http://www.ecogene.org/geneInfo.php?eg_id=EG10967 EnsemblBacteria AAC76675 http://www.ensemblgenomes.org/id/AAC76675 EnsemblBacteria AAC76675 http://www.ensemblgenomes.org/id/AAC76675 EnsemblBacteria BAE77642 http://www.ensemblgenomes.org/id/BAE77642 EnsemblBacteria BAE77642 http://www.ensemblgenomes.org/id/BAE77642 EnsemblBacteria BAE77642 http://www.ensemblgenomes.org/id/BAE77642 EnsemblBacteria b3651 http://www.ensemblgenomes.org/id/b3651 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000049 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0009020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009020 GO_process GO:0002938 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002938 GO_process GO:0030488 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030488 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 Gene3D 3.40.1280.10 http://www.cathdb.info/version/latest/superfamily/3.40.1280.10 GeneID 948161 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948161 HAMAP MF_02060 http://hamap.expasy.org/unirule/MF_02060 HOGENOM HOG000285175 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000285175&db=HOGENOM6 InParanoid P0AGJ2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGJ2 IntAct P0AGJ2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AGJ2* IntEnz 2.1.1.34 {ECO:0000255|HAMAP-Rule:MF_02060, ECO:0000269|PubMed:9321663} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.34 {ECO:0000255|HAMAP-Rule:MF_02060, ECO:0000269|PubMed:9321663} InterPro IPR001537 http://www.ebi.ac.uk/interpro/entry/IPR001537 InterPro IPR022724 http://www.ebi.ac.uk/interpro/entry/IPR022724 InterPro IPR029026 http://www.ebi.ac.uk/interpro/entry/IPR029026 InterPro IPR029028 http://www.ebi.ac.uk/interpro/entry/IPR029028 InterPro IPR033671 http://www.ebi.ac.uk/interpro/entry/IPR033671 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW3626 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3626 KEGG_Gene eco:b3651 http://www.genome.jp/dbget-bin/www_bget?eco:b3651 KEGG_Orthology KO:K00556 http://www.genome.jp/dbget-bin/www_bget?KO:K00556 OMA VHAVWPT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VHAVWPT PSORT swissprot:TRMH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRMH_ECOLI PSORT-B swissprot:TRMH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRMH_ECOLI PSORT2 swissprot:TRMH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRMH_ECOLI Pfam PF00588 http://pfam.xfam.org/family/PF00588 Pfam PF12105 http://pfam.xfam.org/family/PF12105 Phobius swissprot:TRMH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRMH_ECOLI PhylomeDB P0AGJ2 http://phylomedb.org/?seqid=P0AGJ2 ProteinModelPortal P0AGJ2 http://www.proteinmodelportal.org/query/uniprot/P0AGJ2 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2005134 http://www.ncbi.nlm.nih.gov/pubmed/2005134 PubMed 2549050 http://www.ncbi.nlm.nih.gov/pubmed/2549050 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 8265370 http://www.ncbi.nlm.nih.gov/pubmed/8265370 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9321663 http://www.ncbi.nlm.nih.gov/pubmed/9321663 RefSeq NP_418108 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418108 RefSeq WP_001070177 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001070177 SMR P0AGJ2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AGJ2 STRING 511145.b3651 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3651&targetmode=cogs STRING COG0566 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0566&targetmode=cogs SUPFAM SSF75217 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF75217 UniProtKB TRMH_ECOLI http://www.uniprot.org/uniprot/TRMH_ECOLI UniProtKB-AC P0AGJ2 http://www.uniprot.org/uniprot/P0AGJ2 charge swissprot:TRMH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRMH_ECOLI eggNOG COG0566 http://eggnogapi.embl.de/nog_data/html/tree/COG0566 eggNOG ENOG4105FE8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FE8 epestfind swissprot:TRMH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRMH_ECOLI garnier swissprot:TRMH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRMH_ECOLI helixturnhelix swissprot:TRMH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRMH_ECOLI hmoment swissprot:TRMH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRMH_ECOLI iep swissprot:TRMH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRMH_ECOLI inforesidue swissprot:TRMH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRMH_ECOLI octanol swissprot:TRMH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRMH_ECOLI pepcoil swissprot:TRMH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRMH_ECOLI pepdigest swissprot:TRMH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRMH_ECOLI pepinfo swissprot:TRMH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRMH_ECOLI pepnet swissprot:TRMH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRMH_ECOLI pepstats swissprot:TRMH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRMH_ECOLI pepwheel swissprot:TRMH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRMH_ECOLI pepwindow swissprot:TRMH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRMH_ECOLI sigcleave swissprot:TRMH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRMH_ECOLI ## Database ID URL or Descriptions # BioGrid 4260826 33 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG14368 ykfJ # GO_function GO:0008452 RNA ligase activity; IEA:InterPro. # GO_process GO:0006396 RNA processing; IEA:InterPro. # GOslim_function GO:0016874 ligase activity # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # IntAct P75675 8 # InterPro IPR001233 RtcB # Organism YKFJ_ECOLI Escherichia coli (strain K12) # PATRIC 48659663 VBIEscCol107702_0229 # PIR D64748 D64748 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YKFJ_ECOLI Putative uncharacterized protein YkfJ # RefSeq WP_001295202 NZ_LN832404.1 # SUPFAM SSF103365 SSF103365 # eggNOG COG1690 LUCA BLAST swissprot:YKFJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YKFJ_ECOLI BioCyc ECOL316407:JW0225-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0225-MONOMER BioCyc EcoCyc:G6119-MONOMER http://biocyc.org/getid?id=EcoCyc:G6119-MONOMER DIP DIP-48205N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48205N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4112 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4112 EcoGene EG14368 http://www.ecogene.org/geneInfo.php?eg_id=EG14368 EnsemblBacteria BAA77904 http://www.ensemblgenomes.org/id/BAA77904 EnsemblBacteria BAA77904 http://www.ensemblgenomes.org/id/BAA77904 EnsemblBacteria BAA77904 http://www.ensemblgenomes.org/id/BAA77904 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008452 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008452 GO_process GO:0006396 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006396 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 IntAct P75675 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75675* InterPro IPR001233 http://www.ebi.ac.uk/interpro/entry/IPR001233 KEGG_Gene ecj:JW0225 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0225 OMA FYPARRR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FYPARRR PSORT swissprot:YKFJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YKFJ_ECOLI PSORT-B swissprot:YKFJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YKFJ_ECOLI PSORT2 swissprot:YKFJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YKFJ_ECOLI Phobius swissprot:YKFJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YKFJ_ECOLI ProteinModelPortal P75675 http://www.proteinmodelportal.org/query/uniprot/P75675 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001295202 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295202 SMR P75675 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75675 STRING 316407.85674390 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85674390&targetmode=cogs SUPFAM SSF103365 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103365 UniProtKB YKFJ_ECOLI http://www.uniprot.org/uniprot/YKFJ_ECOLI UniProtKB-AC P75675 http://www.uniprot.org/uniprot/P75675 charge swissprot:YKFJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YKFJ_ECOLI eggNOG COG1690 http://eggnogapi.embl.de/nog_data/html/tree/COG1690 epestfind swissprot:YKFJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YKFJ_ECOLI garnier swissprot:YKFJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YKFJ_ECOLI helixturnhelix swissprot:YKFJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YKFJ_ECOLI hmoment swissprot:YKFJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YKFJ_ECOLI iep swissprot:YKFJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YKFJ_ECOLI inforesidue swissprot:YKFJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YKFJ_ECOLI octanol swissprot:YKFJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YKFJ_ECOLI pepcoil swissprot:YKFJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YKFJ_ECOLI pepdigest swissprot:YKFJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YKFJ_ECOLI pepinfo swissprot:YKFJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YKFJ_ECOLI pepnet swissprot:YKFJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YKFJ_ECOLI pepstats swissprot:YKFJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YKFJ_ECOLI pepwheel swissprot:YKFJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YKFJ_ECOLI pepwindow swissprot:YKFJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YKFJ_ECOLI sigcleave swissprot:YKFJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YKFJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4260751 4 # CDD cd06170 LuxR_C_like # EcoGene EG11103 fimZ # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0000160 phosphorelay signal transduction system; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0042493 response to drug; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # IntAct P0AEL8 4 # InterPro IPR000792 Tscrpt_reg_LuxR_C # InterPro IPR001789 Sig_transdc_resp-reg_receiver # InterPro IPR011006 CheY-like_superfamily # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR016032 Sig_transdc_resp-reg_C-effctor # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # Organism FIMZ_ECOLI Escherichia coli (strain K12) # PATRIC 32116230 VBIEscCol129921_0556 # PIR F64785 QQECY5 # PRINTS PR00038 HTHLUXR # PROSITE PS00622 HTH_LUXR_1 # PROSITE PS50043 HTH_LUXR_2 # PROSITE PS50110 RESPONSE_REGULATORY # Pfam PF00072 Response_reg # Pfam PF00196 GerE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FIMZ_ECOLI Fimbriae Z protein # RefSeq NP_415068 NC_000913.3 # RefSeq WP_000805428 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40733.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA35973.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Contains 1 HTH luxR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00411}. # SIMILARITY Contains 1 response regulatory domain. {ECO:0000255|PROSITE-ProRule PRU00169}. # SMART SM00421 HTH_LUXR # SMART SM00448 REC # SUBCELLULAR LOCATION FIMZ_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF46894 SSF46894 # SUPFAM SSF52172 SSF52172 # eggNOG COG2197 LUCA # eggNOG ENOG4108Q9V Bacteria BLAST swissprot:FIMZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FIMZ_ECOLI BioCyc ECOL316407:JW5073-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5073-MONOMER BioCyc EcoCyc:EG11103-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11103-MONOMER COG COG2197 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2197 DIP DIP-48119N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48119N DOI 10.1007/BF00260503 http://dx.doi.org/10.1007/BF00260503 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EMBL X51662 http://www.ebi.ac.uk/ena/data/view/X51662 EchoBASE EB1095 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1095 EcoGene EG11103 http://www.ecogene.org/geneInfo.php?eg_id=EG11103 EnsemblBacteria AAC73637 http://www.ensemblgenomes.org/id/AAC73637 EnsemblBacteria AAC73637 http://www.ensemblgenomes.org/id/AAC73637 EnsemblBacteria BAE76312 http://www.ensemblgenomes.org/id/BAE76312 EnsemblBacteria BAE76312 http://www.ensemblgenomes.org/id/BAE76312 EnsemblBacteria BAE76312 http://www.ensemblgenomes.org/id/BAE76312 EnsemblBacteria b0535 http://www.ensemblgenomes.org/id/b0535 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0042493 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 947079 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947079 HOGENOM HOG000034813 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000034813&db=HOGENOM6 InParanoid P0AEL8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEL8 IntAct P0AEL8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEL8* InterPro IPR000792 http://www.ebi.ac.uk/interpro/entry/IPR000792 InterPro IPR001789 http://www.ebi.ac.uk/interpro/entry/IPR001789 InterPro IPR011006 http://www.ebi.ac.uk/interpro/entry/IPR011006 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR016032 http://www.ebi.ac.uk/interpro/entry/IPR016032 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW5073 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5073 KEGG_Gene eco:b0535 http://www.genome.jp/dbget-bin/www_bget?eco:b0535 KEGG_Orthology KO:K07688 http://www.genome.jp/dbget-bin/www_bget?KO:K07688 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 MINT MINT-1275851 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1275851 OMA RMLLSNK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RMLLSNK PRINTS PR00038 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00038 PROSITE PS00622 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00622 PROSITE PS50043 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50043 PROSITE PS50110 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50110 PSORT swissprot:FIMZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FIMZ_ECOLI PSORT-B swissprot:FIMZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FIMZ_ECOLI PSORT2 swissprot:FIMZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FIMZ_ECOLI Pfam PF00072 http://pfam.xfam.org/family/PF00072 Pfam PF00196 http://pfam.xfam.org/family/PF00196 Phobius swissprot:FIMZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FIMZ_ECOLI PhylomeDB P0AEL8 http://phylomedb.org/?seqid=P0AEL8 ProteinModelPortal P0AEL8 http://www.proteinmodelportal.org/query/uniprot/P0AEL8 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2183007 http://www.ncbi.nlm.nih.gov/pubmed/2183007 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415068 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415068 RefSeq WP_000805428 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000805428 SMART SM00421 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00421 SMART SM00448 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00448 SMR P0AEL8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEL8 STRING 511145.b0535 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0535&targetmode=cogs STRING COG2197 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2197&targetmode=cogs SUPFAM SSF46894 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46894 SUPFAM SSF52172 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52172 UniProtKB FIMZ_ECOLI http://www.uniprot.org/uniprot/FIMZ_ECOLI UniProtKB-AC P0AEL8 http://www.uniprot.org/uniprot/P0AEL8 charge swissprot:FIMZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FIMZ_ECOLI eggNOG COG2197 http://eggnogapi.embl.de/nog_data/html/tree/COG2197 eggNOG ENOG4108Q9V http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Q9V epestfind swissprot:FIMZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FIMZ_ECOLI garnier swissprot:FIMZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FIMZ_ECOLI helixturnhelix swissprot:FIMZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FIMZ_ECOLI hmoment swissprot:FIMZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FIMZ_ECOLI iep swissprot:FIMZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FIMZ_ECOLI inforesidue swissprot:FIMZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FIMZ_ECOLI octanol swissprot:FIMZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FIMZ_ECOLI pepcoil swissprot:FIMZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FIMZ_ECOLI pepdigest swissprot:FIMZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FIMZ_ECOLI pepinfo swissprot:FIMZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FIMZ_ECOLI pepnet swissprot:FIMZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FIMZ_ECOLI pepstats swissprot:FIMZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FIMZ_ECOLI pepwheel swissprot:FIMZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FIMZ_ECOLI pepwindow swissprot:FIMZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FIMZ_ECOLI sigcleave swissprot:FIMZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FIMZ_ECOLI ## Database ID URL or Descriptions # BioGrid 4262764 181 # EcoGene EG10575 mcrC # FUNCTION MCRC_ECOLI Modifies the specificity of McrB restriction by expanding the range of modified sequences restricted. Does not bind to DNA. # GO_process GO:0009307 DNA restriction-modification system; IEA:UniProtKB-KW. # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # InterPro IPR014407 McrC_bac # InterPro IPR019292 Restrct_system_McrC # Organism MCRC_ECOLI Escherichia coli (strain K12) # PATRIC 32124296 VBIEscCol129921_4491 # PIR JS0121 BVECMB # PIRSF PIRSF003109 McrC # Pfam PF10117 McrBC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # REBASE 2865 EcoKMcrBC # RecName MCRC_ECOLI Protein McrC # RefSeq NP_418765 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA24146.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # eggNOG COG4268 LUCA # eggNOG ENOG4107SQC Bacteria BLAST swissprot:MCRC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MCRC_ECOLI BioCyc ECOL316407:JW5789-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5789-MONOMER BioCyc EcoCyc:EG10575-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10575-MONOMER BioCyc MetaCyc:EG10575-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10575-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M24927 http://www.ebi.ac.uk/ena/data/view/M24927 EMBL M58752 http://www.ebi.ac.uk/ena/data/view/M58752 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB0570 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0570 EcoGene EG10575 http://www.ecogene.org/geneInfo.php?eg_id=EG10575 EnsemblBacteria AAC77301 http://www.ensemblgenomes.org/id/AAC77301 EnsemblBacteria AAC77301 http://www.ensemblgenomes.org/id/AAC77301 EnsemblBacteria BAE78335 http://www.ensemblgenomes.org/id/BAE78335 EnsemblBacteria BAE78335 http://www.ensemblgenomes.org/id/BAE78335 EnsemblBacteria BAE78335 http://www.ensemblgenomes.org/id/BAE78335 EnsemblBacteria b4345 http://www.ensemblgenomes.org/id/b4345 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0009307 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009307 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 948880 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948880 HOGENOM HOG000081316 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000081316&db=HOGENOM6 InParanoid P15006 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P15006 InterPro IPR014407 http://www.ebi.ac.uk/interpro/entry/IPR014407 InterPro IPR019292 http://www.ebi.ac.uk/interpro/entry/IPR019292 KEGG_Gene ecj:JW5789 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5789 KEGG_Gene eco:b4345 http://www.genome.jp/dbget-bin/www_bget?eco:b4345 OMA IPIRNLW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IPIRNLW PSORT swissprot:MCRC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MCRC_ECOLI PSORT-B swissprot:MCRC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MCRC_ECOLI PSORT2 swissprot:MCRC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MCRC_ECOLI Pfam PF10117 http://pfam.xfam.org/family/PF10117 Phobius swissprot:MCRC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MCRC_ECOLI ProteinModelPortal P15006 http://www.proteinmodelportal.org/query/uniprot/P15006 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2050643 http://www.ncbi.nlm.nih.gov/pubmed/2050643 PubMed 2203735 http://www.ncbi.nlm.nih.gov/pubmed/2203735 PubMed 2649480 http://www.ncbi.nlm.nih.gov/pubmed/2649480 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 REBASE 2865 http://rebase.neb.com/rebase/enz/2865.html RefSeq NP_418765 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418765 STRING 511145.b4345 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4345&targetmode=cogs UniProtKB MCRC_ECOLI http://www.uniprot.org/uniprot/MCRC_ECOLI UniProtKB-AC P15006 http://www.uniprot.org/uniprot/P15006 charge swissprot:MCRC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MCRC_ECOLI eggNOG COG4268 http://eggnogapi.embl.de/nog_data/html/tree/COG4268 eggNOG ENOG4107SQC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107SQC epestfind swissprot:MCRC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MCRC_ECOLI garnier swissprot:MCRC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MCRC_ECOLI helixturnhelix swissprot:MCRC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MCRC_ECOLI hmoment swissprot:MCRC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MCRC_ECOLI iep swissprot:MCRC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MCRC_ECOLI inforesidue swissprot:MCRC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MCRC_ECOLI octanol swissprot:MCRC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MCRC_ECOLI pepcoil swissprot:MCRC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MCRC_ECOLI pepdigest swissprot:MCRC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MCRC_ECOLI pepinfo swissprot:MCRC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MCRC_ECOLI pepnet swissprot:MCRC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MCRC_ECOLI pepstats swissprot:MCRC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MCRC_ECOLI pepwheel swissprot:MCRC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MCRC_ECOLI pepwindow swissprot:MCRC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MCRC_ECOLI sigcleave swissprot:MCRC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MCRC_ECOLI ## Database ID URL or Descriptions # AltName YTFE_ECOLI Regulator of cell morphogenesis and NO signaling # BioGrid 4263431 77 # DISRUPTION PHENOTYPE YTFE_ECOLI Mutants show a severe growth impairment under nitrosative and oxidative stress conditions. Mutation increases the sensitivity of the bacterium to iron starvation, increases the intracellular levels of free iron, and decreases the activity of several iron-sulfur-containing proteins. {ECO 0000269|PubMed 15546870, ECO 0000269|PubMed 16553864, ECO 0000269|PubMed 17289666}. # EcoGene EG12505 ytfE # FUNCTION YTFE_ECOLI Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions. {ECO 0000269|PubMed 16553864, ECO 0000269|PubMed 17289666, ECO 0000269|PubMed 18357473}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006950 response to stress; IEA:UniProtKB-HAMAP. # GO_process GO:0030091 protein repair; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # HAMAP MF_01606 RIC_YtfE # INDUCTION YTFE_ECOLI Induced by nitric oxide. Negatively regulated by Fnr and Fur, but no obvious Fnr or Fur binding sites were found, suggesting that this regulation could be indirect. {ECO 0000269|PubMed 15546870, ECO 0000269|PubMed 16553864}. # InterPro IPR012312 Haemerythrin-like # InterPro IPR019903 RIC_family # InterPro IPR023742 FeS-repair_YftE # Organism YTFE_ECOLI Escherichia coli (strain K12) # PATRIC 32123993 VBIEscCol129921_4341 # PDB 5FNN X-ray; 2.09 A; A/B=1-220 # PDB 5FNP X-ray; 1.80 A; A/B=1-220 # PDB 5FNY X-ray; 2.01 A; A/B=1-220 # PIR S56434 S56434 # Pfam PF01814 Hemerythrin # Pfam PF04405 ScdA_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YTFE_ECOLI Iron-sulfur cluster repair protein YtfE # RefSeq NP_418630 NC_000913.3 # RefSeq WP_000331456 NZ_LN832404.1 # SIMILARITY Belongs to the RIC family. YtfE subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION YTFE_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 18357473}. # TIGRFAMs TIGR03652 FeS_repair_RIC # eggNOG COG2846 LUCA # eggNOG ENOG4105FJH Bacteria BLAST swissprot:YTFE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YTFE_ECOLI BioCyc ECOL316407:JW4167-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4167-MONOMER BioCyc EcoCyc:G7866-MONOMER http://biocyc.org/getid?id=EcoCyc:G7866-MONOMER COG COG2846 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2846 DIP DIP-35833N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35833N DOI 10.1007/s00775-008-0362-y http://dx.doi.org/10.1007/s00775-008-0362-y DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M411070200 http://dx.doi.org/10.1074/jbc.M411070200 DOI 10.1074/jbc.M610656200 http://dx.doi.org/10.1074/jbc.M610656200 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1111/j.1574-6968.2006.00179.x http://dx.doi.org/10.1111/j.1574-6968.2006.00179.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2398 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2398 EcoGene EG12505 http://www.ecogene.org/geneInfo.php?eg_id=EG12505 EnsemblBacteria AAC77166 http://www.ensemblgenomes.org/id/AAC77166 EnsemblBacteria AAC77166 http://www.ensemblgenomes.org/id/AAC77166 EnsemblBacteria BAE78210 http://www.ensemblgenomes.org/id/BAE78210 EnsemblBacteria BAE78210 http://www.ensemblgenomes.org/id/BAE78210 EnsemblBacteria BAE78210 http://www.ensemblgenomes.org/id/BAE78210 EnsemblBacteria b4209 http://www.ensemblgenomes.org/id/b4209 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GO_process GO:0030091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030091 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 948724 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948724 HAMAP MF_01606 http://hamap.expasy.org/unirule/MF_01606 HOGENOM HOG000286324 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000286324&db=HOGENOM6 InParanoid P69506 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P69506 IntAct P69506 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69506* InterPro IPR012312 http://www.ebi.ac.uk/interpro/entry/IPR012312 InterPro IPR019903 http://www.ebi.ac.uk/interpro/entry/IPR019903 InterPro IPR023742 http://www.ebi.ac.uk/interpro/entry/IPR023742 KEGG_Gene ecj:JW4167 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4167 KEGG_Gene eco:b4209 http://www.genome.jp/dbget-bin/www_bget?eco:b4209 KEGG_Orthology KO:K07322 http://www.genome.jp/dbget-bin/www_bget?KO:K07322 OMA ACTTWRV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ACTTWRV PDB 5FNN http://www.ebi.ac.uk/pdbe-srv/view/entry/5FNN PDB 5FNP http://www.ebi.ac.uk/pdbe-srv/view/entry/5FNP PDB 5FNY http://www.ebi.ac.uk/pdbe-srv/view/entry/5FNY PDBsum 5FNN http://www.ebi.ac.uk/pdbsum/5FNN PDBsum 5FNP http://www.ebi.ac.uk/pdbsum/5FNP PDBsum 5FNY http://www.ebi.ac.uk/pdbsum/5FNY PSORT swissprot:YTFE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YTFE_ECOLI PSORT-B swissprot:YTFE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YTFE_ECOLI PSORT2 swissprot:YTFE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YTFE_ECOLI Pfam PF01814 http://pfam.xfam.org/family/PF01814 Pfam PF04405 http://pfam.xfam.org/family/PF04405 Phobius swissprot:YTFE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YTFE_ECOLI PhylomeDB P69506 http://phylomedb.org/?seqid=P69506 ProteinModelPortal P69506 http://www.proteinmodelportal.org/query/uniprot/P69506 PubMed 15546870 http://www.ncbi.nlm.nih.gov/pubmed/15546870 PubMed 16553864 http://www.ncbi.nlm.nih.gov/pubmed/16553864 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17289666 http://www.ncbi.nlm.nih.gov/pubmed/17289666 PubMed 18357473 http://www.ncbi.nlm.nih.gov/pubmed/18357473 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418630 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418630 RefSeq WP_000331456 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000331456 SMR P69506 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69506 STRING 511145.b4209 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4209&targetmode=cogs STRING COG2846 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2846&targetmode=cogs TIGRFAMs TIGR03652 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03652 UniProtKB YTFE_ECOLI http://www.uniprot.org/uniprot/YTFE_ECOLI UniProtKB-AC P69506 http://www.uniprot.org/uniprot/P69506 charge swissprot:YTFE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YTFE_ECOLI eggNOG COG2846 http://eggnogapi.embl.de/nog_data/html/tree/COG2846 eggNOG ENOG4105FJH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FJH epestfind swissprot:YTFE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YTFE_ECOLI garnier swissprot:YTFE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YTFE_ECOLI helixturnhelix swissprot:YTFE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YTFE_ECOLI hmoment swissprot:YTFE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YTFE_ECOLI iep swissprot:YTFE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YTFE_ECOLI inforesidue swissprot:YTFE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YTFE_ECOLI octanol swissprot:YTFE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YTFE_ECOLI pepcoil swissprot:YTFE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YTFE_ECOLI pepdigest swissprot:YTFE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YTFE_ECOLI pepinfo swissprot:YTFE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YTFE_ECOLI pepnet swissprot:YTFE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YTFE_ECOLI pepstats swissprot:YTFE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YTFE_ECOLI pepwheel swissprot:YTFE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YTFE_ECOLI pepwindow swissprot:YTFE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YTFE_ECOLI sigcleave swissprot:YTFE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YTFE_ECOLI ## Database ID URL or Descriptions # EcoGene EG14475 yjeV # INDUCTION In exponential phase (at protein level). {ECO:0000269|PubMed 19121005}. # Organism YJEV_ECOLI Escherichia coli (strain K12) # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJEV_ECOLI Uncharacterized protein YjeV # RefSeq YP_002791261 NC_000913.3 BLAST swissprot:YJEV_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJEV_ECOLI BioCyc EcoCyc:MONOMER0-2869 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2869 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2008.06495.x http://dx.doi.org/10.1111/j.1365-2958.2008.06495.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14475 http://www.ecogene.org/geneInfo.php?eg_id=EG14475 EnsemblBacteria ACO60013 http://www.ensemblgenomes.org/id/ACO60013 EnsemblBacteria ACO60013 http://www.ensemblgenomes.org/id/ACO60013 EnsemblBacteria b4670 http://www.ensemblgenomes.org/id/b4670 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 7751630 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7751630 KEGG_Gene eco:b4670 http://www.genome.jp/dbget-bin/www_bget?eco:b4670 PSORT swissprot:YJEV_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJEV_ECOLI PSORT-B swissprot:YJEV_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJEV_ECOLI PSORT2 swissprot:YJEV_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJEV_ECOLI Phobius swissprot:YJEV_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJEV_ECOLI PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19121005 http://www.ncbi.nlm.nih.gov/pubmed/19121005 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq YP_002791261 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_002791261 UniProtKB YJEV_ECOLI http://www.uniprot.org/uniprot/YJEV_ECOLI UniProtKB-AC C1P621 http://www.uniprot.org/uniprot/C1P621 charge swissprot:YJEV_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJEV_ECOLI epestfind swissprot:YJEV_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJEV_ECOLI garnier swissprot:YJEV_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJEV_ECOLI helixturnhelix swissprot:YJEV_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJEV_ECOLI hmoment swissprot:YJEV_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJEV_ECOLI iep swissprot:YJEV_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJEV_ECOLI inforesidue swissprot:YJEV_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJEV_ECOLI octanol swissprot:YJEV_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJEV_ECOLI pepcoil swissprot:YJEV_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJEV_ECOLI pepdigest swissprot:YJEV_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJEV_ECOLI pepinfo swissprot:YJEV_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJEV_ECOLI pepnet swissprot:YJEV_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJEV_ECOLI pepstats swissprot:YJEV_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJEV_ECOLI pepwheel swissprot:YJEV_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJEV_ECOLI pepwindow swissprot:YJEV_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJEV_ECOLI sigcleave swissprot:YJEV_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJEV_ECOLI ## Database ID URL or Descriptions # BioGrid 4259686 3 # EcoGene EG14051 yegH # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0016614 oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro. # GO_function GO:0050660 flavin adenine dinucleotide binding; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # Gene3D 3.30.465.10 -; 1. # InterPro IPR000644 CBS_dom # InterPro IPR005170 Transptr-assoc_dom # InterPro IPR005496 Integral_membrane_TerC # InterPro IPR016166 FAD-bd_2 # InterPro IPR016169 CO_DH_flavot_FAD-bd_sub2 # Organism YEGH_ECOLI Escherichia coli (strain K12) # PATRIC 32119459 VBIEscCol129921_2140 # PIR F64972 F64972 # PROSITE PS51371 CBS; 2 # Pfam PF00571 CBS; 2 # Pfam PF03471 CorC_HlyC # Pfam PF03741 TerC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEGH_ECOLI UPF0053 protein YegH # RefSeq NP_416567 NC_000913.3 # RefSeq WP_000454701 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0053 family. {ECO 0000305}. # SIMILARITY Contains 2 CBS domains. {ECO:0000255|PROSITE- ProRule PRU00703}. # SMART SM00116 CBS; 2 # SMART SM01091 CorC_HlyC # SUBCELLULAR LOCATION YEGH_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # SUPFAM SSF56176 SSF56176 # eggNOG COG0861 LUCA # eggNOG COG1253 LUCA # eggNOG ENOG4105EE5 Bacteria BLAST swissprot:YEGH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEGH_ECOLI BioCyc ECOL316407:JW5336-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5336-MONOMER BioCyc EcoCyc:G7108-MONOMER http://biocyc.org/getid?id=EcoCyc:G7108-MONOMER DIP DIP-11879N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11879N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3804 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3804 EcoGene EG14051 http://www.ecogene.org/geneInfo.php?eg_id=EG14051 EnsemblBacteria AAC75124 http://www.ensemblgenomes.org/id/AAC75124 EnsemblBacteria AAC75124 http://www.ensemblgenomes.org/id/AAC75124 EnsemblBacteria BAA15916 http://www.ensemblgenomes.org/id/BAA15916 EnsemblBacteria BAA15916 http://www.ensemblgenomes.org/id/BAA15916 EnsemblBacteria BAA15916 http://www.ensemblgenomes.org/id/BAA15916 EnsemblBacteria b2063 http://www.ensemblgenomes.org/id/b2063 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0016614 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016614 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.30.465.10 http://www.cathdb.info/version/latest/superfamily/3.30.465.10 GeneID 946566 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946566 HOGENOM HOG000279402 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000279402&db=HOGENOM6 InParanoid P76389 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76389 InterPro IPR000644 http://www.ebi.ac.uk/interpro/entry/IPR000644 InterPro IPR005170 http://www.ebi.ac.uk/interpro/entry/IPR005170 InterPro IPR005496 http://www.ebi.ac.uk/interpro/entry/IPR005496 InterPro IPR016166 http://www.ebi.ac.uk/interpro/entry/IPR016166 InterPro IPR016169 http://www.ebi.ac.uk/interpro/entry/IPR016169 KEGG_Gene ecj:JW5336 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5336 KEGG_Gene eco:b2063 http://www.genome.jp/dbget-bin/www_bget?eco:b2063 OMA MVMRLLL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MVMRLLL PROSITE PS51371 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51371 PSORT swissprot:YEGH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEGH_ECOLI PSORT-B swissprot:YEGH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEGH_ECOLI PSORT2 swissprot:YEGH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEGH_ECOLI Pfam PF00571 http://pfam.xfam.org/family/PF00571 Pfam PF03471 http://pfam.xfam.org/family/PF03471 Pfam PF03741 http://pfam.xfam.org/family/PF03741 Phobius swissprot:YEGH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEGH_ECOLI PhylomeDB P76389 http://phylomedb.org/?seqid=P76389 ProteinModelPortal P76389 http://www.proteinmodelportal.org/query/uniprot/P76389 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416567 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416567 RefSeq WP_000454701 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000454701 SMART SM00116 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00116 SMART SM01091 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01091 SMR P76389 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76389 STRING 511145.b2063 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2063&targetmode=cogs SUPFAM SSF56176 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56176 UniProtKB YEGH_ECOLI http://www.uniprot.org/uniprot/YEGH_ECOLI UniProtKB-AC P76389 http://www.uniprot.org/uniprot/P76389 charge swissprot:YEGH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEGH_ECOLI eggNOG COG0861 http://eggnogapi.embl.de/nog_data/html/tree/COG0861 eggNOG COG1253 http://eggnogapi.embl.de/nog_data/html/tree/COG1253 eggNOG ENOG4105EE5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EE5 epestfind swissprot:YEGH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEGH_ECOLI garnier swissprot:YEGH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEGH_ECOLI helixturnhelix swissprot:YEGH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEGH_ECOLI hmoment swissprot:YEGH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEGH_ECOLI iep swissprot:YEGH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEGH_ECOLI inforesidue swissprot:YEGH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEGH_ECOLI octanol swissprot:YEGH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEGH_ECOLI pepcoil swissprot:YEGH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEGH_ECOLI pepdigest swissprot:YEGH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEGH_ECOLI pepinfo swissprot:YEGH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEGH_ECOLI pepnet swissprot:YEGH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEGH_ECOLI pepstats swissprot:YEGH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEGH_ECOLI pepwheel swissprot:YEGH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEGH_ECOLI pepwindow swissprot:YEGH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEGH_ECOLI sigcleave swissprot:YEGH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEGH_ECOLI ## Database ID URL or Descriptions # BioGrid 4261786 34 # COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI 597326; Evidence={ECO:0000250}; # EcoGene EG12979 yggS # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0030170 pyridoxal phosphate binding; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0043167 ion binding # Gene3D 3.20.20.10 -; 1. # IntAct P67080 9 # InterPro IPR001608 Ala_racemase_N # InterPro IPR011078 UPF0001 # InterPro IPR029066 PLP-binding_barrel # Organism YGGS_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10146 PTHR10146 # PATRIC 32121314 VBIEscCol129921_3045 # PDB 1W8G X-ray; 2.00 A; A=1-234 # PDB 3SY1 X-ray; 1.46 A; A=1-234 # PIR F65080 F65080 # PIRSF PIRSF004848 YBL036c_PLPDEIII # PROSITE PS01211 UPF0001 # Pfam PF01168 Ala_racemase_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGGS_ECOLI UPF0001 protein YggS # RefSeq NP_417426 NC_000913.3 # RefSeq WP_000997795 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0001 family. {ECO 0000305}. # SUPFAM SSF51419 SSF51419 # TIGRFAMs TIGR00044 TIGR00044 # eggNOG COG0325 LUCA # eggNOG ENOG4105DFA Bacteria BLAST swissprot:YGGS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGGS_ECOLI BioCyc ECOL316407:JW2918-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2918-MONOMER BioCyc EcoCyc:G7527-MONOMER http://biocyc.org/getid?id=EcoCyc:G7527-MONOMER COG COG0325 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0325 DIP DIP-12194N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12194N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2804 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2804 EcoGene EG12979 http://www.ecogene.org/geneInfo.php?eg_id=EG12979 EnsemblBacteria AAC75988 http://www.ensemblgenomes.org/id/AAC75988 EnsemblBacteria AAC75988 http://www.ensemblgenomes.org/id/AAC75988 EnsemblBacteria BAE77014 http://www.ensemblgenomes.org/id/BAE77014 EnsemblBacteria BAE77014 http://www.ensemblgenomes.org/id/BAE77014 EnsemblBacteria BAE77014 http://www.ensemblgenomes.org/id/BAE77014 EnsemblBacteria b2951 http://www.ensemblgenomes.org/id/b2951 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.20.20.10 http://www.cathdb.info/version/latest/superfamily/3.20.20.10 GeneID 947423 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947423 HOGENOM HOG000048983 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000048983&db=HOGENOM6 InParanoid P67080 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P67080 IntAct P67080 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P67080* InterPro IPR001608 http://www.ebi.ac.uk/interpro/entry/IPR001608 InterPro IPR011078 http://www.ebi.ac.uk/interpro/entry/IPR011078 InterPro IPR029066 http://www.ebi.ac.uk/interpro/entry/IPR029066 KEGG_Gene ecj:JW2918 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2918 KEGG_Gene eco:b2951 http://www.genome.jp/dbget-bin/www_bget?eco:b2951 KEGG_Orthology KO:K06997 http://www.genome.jp/dbget-bin/www_bget?KO:K06997 MINT MINT-1236179 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1236179 OMA HGSTMVR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HGSTMVR PANTHER PTHR10146 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10146 PDB 1W8G http://www.ebi.ac.uk/pdbe-srv/view/entry/1W8G PDB 3SY1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3SY1 PDBsum 1W8G http://www.ebi.ac.uk/pdbsum/1W8G PDBsum 3SY1 http://www.ebi.ac.uk/pdbsum/3SY1 PROSITE PS01211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01211 PSORT swissprot:YGGS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGGS_ECOLI PSORT-B swissprot:YGGS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGGS_ECOLI PSORT2 swissprot:YGGS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGGS_ECOLI Pfam PF01168 http://pfam.xfam.org/family/PF01168 Phobius swissprot:YGGS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGGS_ECOLI PhylomeDB P67080 http://phylomedb.org/?seqid=P67080 ProteinModelPortal P67080 http://www.proteinmodelportal.org/query/uniprot/P67080 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417426 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417426 RefSeq WP_000997795 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000997795 SMR P67080 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P67080 STRING 511145.b2951 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2951&targetmode=cogs STRING COG0325 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0325&targetmode=cogs SUPFAM SSF51419 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51419 TIGRFAMs TIGR00044 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00044 UniProtKB YGGS_ECOLI http://www.uniprot.org/uniprot/YGGS_ECOLI UniProtKB-AC P67080 http://www.uniprot.org/uniprot/P67080 charge swissprot:YGGS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGGS_ECOLI eggNOG COG0325 http://eggnogapi.embl.de/nog_data/html/tree/COG0325 eggNOG ENOG4105DFA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DFA epestfind swissprot:YGGS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGGS_ECOLI garnier swissprot:YGGS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGGS_ECOLI helixturnhelix swissprot:YGGS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGGS_ECOLI hmoment swissprot:YGGS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGGS_ECOLI iep swissprot:YGGS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGGS_ECOLI inforesidue swissprot:YGGS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGGS_ECOLI octanol swissprot:YGGS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGGS_ECOLI pepcoil swissprot:YGGS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGGS_ECOLI pepdigest swissprot:YGGS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGGS_ECOLI pepinfo swissprot:YGGS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGGS_ECOLI pepnet swissprot:YGGS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGGS_ECOLI pepstats swissprot:YGGS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGGS_ECOLI pepwheel swissprot:YGGS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGGS_ECOLI pepwindow swissprot:YGGS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGGS_ECOLI sigcleave swissprot:YGGS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGGS_ECOLI ## Database ID URL or Descriptions # BioGrid 4259476 2 # EcoGene EG10591 metR # FUNCTION METR_ECOLI Control of the last step in methionine biosynthesis; MetR is a positive activator of the metA, metE and metH genes. MetR is also a negative regulator of its own expression. Binds homocysteine as an inducer. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_function GO:0016597 amino acid binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IMP:EcoCyc. # GO_process GO:0009086 methionine biosynthetic process; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # IntAct P0A9F9 8 # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR005119 LysR_subst-bd # InterPro IPR011991 WHTH_DNA-bd_dom # KEGG_Brite ko03000 Transcription factors # Organism METR_ECOLI Escherichia coli (strain K12) # PATRIC 32123157 VBIEscCol129921_3944 # PDB 5FO5 X-ray; 2.16 A; A=1-92 # PIR A36066 A36066 # PRINTS PR00039 HTHLYSR # PROSITE PS50931 HTH_LYSR # Pfam PF00126 HTH_1 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName METR_ECOLI HTH-type transcriptional regulator MetR # RefSeq NP_418272 NC_000913.3 # RefSeq WP_000573621 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lysR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00253}. # SUBCELLULAR LOCATION METR_ECOLI Cytoplasm. # SUPFAM SSF46785 SSF46785 # eggNOG ENOG4105DZ2 Bacteria # eggNOG ENOG410XQG7 LUCA BLAST swissprot:METR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:METR_ECOLI BioCyc ECOL316407:JW3804-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3804-MONOMER BioCyc EcoCyc:PD03938 http://biocyc.org/getid?id=EcoCyc:PD03938 COG COG0583 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0583 DIP DIP-10198N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10198N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.86.1.85 http://dx.doi.org/10.1073/pnas.86.1.85 DOI 10.1073/pnas.87.18.7076 http://dx.doi.org/10.1073/pnas.87.18.7076 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J04155 http://www.ebi.ac.uk/ena/data/view/J04155 EMBL M37630 http://www.ebi.ac.uk/ena/data/view/M37630 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0586 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0586 EcoGene EG10591 http://www.ecogene.org/geneInfo.php?eg_id=EG10591 EnsemblBacteria AAC76831 http://www.ensemblgenomes.org/id/AAC76831 EnsemblBacteria AAC76831 http://www.ensemblgenomes.org/id/AAC76831 EnsemblBacteria BAE77473 http://www.ensemblgenomes.org/id/BAE77473 EnsemblBacteria BAE77473 http://www.ensemblgenomes.org/id/BAE77473 EnsemblBacteria BAE77473 http://www.ensemblgenomes.org/id/BAE77473 EnsemblBacteria b3828 http://www.ensemblgenomes.org/id/b3828 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0016597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016597 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0009086 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009086 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 948310 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948310 HOGENOM HOG000218906 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218906&db=HOGENOM6 InParanoid P0A9F9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9F9 IntAct P0A9F9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9F9* InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW3804 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3804 KEGG_Gene eco:b3828 http://www.genome.jp/dbget-bin/www_bget?eco:b3828 KEGG_Orthology KO:K03576 http://www.genome.jp/dbget-bin/www_bget?KO:K03576 MINT MINT-1262668 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1262668 OMA ACEHLPF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ACEHLPF PDB 5FO5 http://www.ebi.ac.uk/pdbe-srv/view/entry/5FO5 PDBsum 5FO5 http://www.ebi.ac.uk/pdbsum/5FO5 PRINTS PR00039 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00039 PROSITE PS50931 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50931 PSORT swissprot:METR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:METR_ECOLI PSORT-B swissprot:METR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:METR_ECOLI PSORT2 swissprot:METR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:METR_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:METR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:METR_ECOLI PhylomeDB P0A9F9 http://phylomedb.org/?seqid=P0A9F9 ProteinModelPortal P0A9F9 http://www.proteinmodelportal.org/query/uniprot/P0A9F9 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2205852 http://www.ncbi.nlm.nih.gov/pubmed/2205852 PubMed 2643109 http://www.ncbi.nlm.nih.gov/pubmed/2643109 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418272 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418272 RefSeq WP_000573621 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000573621 SMR P0A9F9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9F9 STRING 511145.b3828 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3828&targetmode=cogs STRING COG0583 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0583&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB METR_ECOLI http://www.uniprot.org/uniprot/METR_ECOLI UniProtKB-AC P0A9F9 http://www.uniprot.org/uniprot/P0A9F9 charge swissprot:METR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:METR_ECOLI eggNOG ENOG4105DZ2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DZ2 eggNOG ENOG410XQG7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQG7 epestfind swissprot:METR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:METR_ECOLI garnier swissprot:METR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:METR_ECOLI helixturnhelix swissprot:METR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:METR_ECOLI hmoment swissprot:METR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:METR_ECOLI iep swissprot:METR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:METR_ECOLI inforesidue swissprot:METR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:METR_ECOLI octanol swissprot:METR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:METR_ECOLI pepcoil swissprot:METR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:METR_ECOLI pepdigest swissprot:METR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:METR_ECOLI pepinfo swissprot:METR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:METR_ECOLI pepnet swissprot:METR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:METR_ECOLI pepstats swissprot:METR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:METR_ECOLI pepwheel swissprot:METR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:METR_ECOLI pepwindow swissprot:METR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:METR_ECOLI sigcleave swissprot:METR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:METR_ECOLI ## Database ID URL or Descriptions # BioGrid 4259182 35 # EcoGene EG14385 ypeC # IntAct P64542 2 # InterPro IPR019638 DUF2502 # Organism YPEC_ECOLI Escherichia coli (strain K12) # PATRIC 32120159 VBIEscCol129921_2488 # PIR C65013 C65013 # Pfam PF10697 DUF2502 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YPEC_ECOLI Uncharacterized protein YpeC # RefSeq NP_416891 NC_000913.3 # RefSeq WP_000490072 NZ_LN832404.1 # SIMILARITY To E.coli YaaX. {ECO 0000305}. # eggNOG ENOG4109076 Bacteria # eggNOG ENOG4111T5E LUCA BLAST swissprot:YPEC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YPEC_ECOLI BioCyc ECOL316407:JW2387-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2387-MONOMER BioCyc EcoCyc:G7252-MONOMER http://biocyc.org/getid?id=EcoCyc:G7252-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4128 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4128 EcoGene EG14385 http://www.ecogene.org/geneInfo.php?eg_id=EG14385 EnsemblBacteria AAC75449 http://www.ensemblgenomes.org/id/AAC75449 EnsemblBacteria AAC75449 http://www.ensemblgenomes.org/id/AAC75449 EnsemblBacteria BAE76709 http://www.ensemblgenomes.org/id/BAE76709 EnsemblBacteria BAE76709 http://www.ensemblgenomes.org/id/BAE76709 EnsemblBacteria BAE76709 http://www.ensemblgenomes.org/id/BAE76709 EnsemblBacteria b2390 http://www.ensemblgenomes.org/id/b2390 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946855 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946855 HOGENOM HOG000116685 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000116685&db=HOGENOM6 IntAct P64542 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P64542* InterPro IPR019638 http://www.ebi.ac.uk/interpro/entry/IPR019638 KEGG_Gene ecj:JW2387 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2387 KEGG_Gene eco:b2390 http://www.genome.jp/dbget-bin/www_bget?eco:b2390 OMA DNGRHRG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DNGRHRG PSORT swissprot:YPEC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YPEC_ECOLI PSORT-B swissprot:YPEC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YPEC_ECOLI PSORT2 swissprot:YPEC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YPEC_ECOLI Pfam PF10697 http://pfam.xfam.org/family/PF10697 Phobius swissprot:YPEC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YPEC_ECOLI ProteinModelPortal P64542 http://www.proteinmodelportal.org/query/uniprot/P64542 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416891 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416891 RefSeq WP_000490072 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000490072 STRING 511145.b2390 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2390&targetmode=cogs UniProtKB YPEC_ECOLI http://www.uniprot.org/uniprot/YPEC_ECOLI UniProtKB-AC P64542 http://www.uniprot.org/uniprot/P64542 charge swissprot:YPEC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YPEC_ECOLI eggNOG ENOG4109076 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4109076 eggNOG ENOG4111T5E http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111T5E epestfind swissprot:YPEC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YPEC_ECOLI garnier swissprot:YPEC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YPEC_ECOLI helixturnhelix swissprot:YPEC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YPEC_ECOLI hmoment swissprot:YPEC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YPEC_ECOLI iep swissprot:YPEC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YPEC_ECOLI inforesidue swissprot:YPEC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YPEC_ECOLI octanol swissprot:YPEC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YPEC_ECOLI pepcoil swissprot:YPEC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YPEC_ECOLI pepdigest swissprot:YPEC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YPEC_ECOLI pepinfo swissprot:YPEC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YPEC_ECOLI pepnet swissprot:YPEC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YPEC_ECOLI pepstats swissprot:YPEC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YPEC_ECOLI pepwheel swissprot:YPEC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YPEC_ECOLI pepwindow swissprot:YPEC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YPEC_ECOLI sigcleave swissprot:YPEC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YPEC_ECOLI ## Database ID URL or Descriptions # BioGrid 4262520 212 # EcoGene EG12240 mdtE # FUNCTION MDTE_ECOLI Part of the tripartite efflux system MdtEF-TolC, which confers resistance to compounds such as rhodamine 6G, erythromycin, doxorubicin, ethidium bromide, TPP, SDS, deoxycholate, crystal violet and benzalkonium. {ECO 0000269|PubMed 11566977}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0031226 intrinsic component of plasma membrane; IBA:GO_Central. # GO_function GO:0015238 drug transmembrane transporter activity; IBA:GO_Central. # GO_process GO:0006855 drug transmembrane transport; IBA:GO_Central. # GO_process GO:0046677 response to antibiotic; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0055085 transmembrane transport # INDUCTION MDTE_ECOLI Induced by EvgA, probably via YdeO. {ECO 0000269|PubMed 11914367, ECO 0000269|PubMed 12399493, ECO 0000269|PubMed 12694615, ECO 0000269|PubMed 14523115}. # IntAct P37636 4 # InterPro IPR006143 RND_pump_MFP # InterPro IPR032317 HlyD_D23 # Organism MDTE_ECOLI Escherichia coli (strain K12) # PATRIC 32122486 VBIEscCol129921_3621 # PIR S47733 S47733 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF00529 HlyD # Pfam PF16576 HlyD_D23 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MDTE_ECOLI Multidrug resistance protein MdtE # RefSeq NP_417970 NC_000913.3 # RefSeq WP_001081984 NZ_LN832404.1 # SIMILARITY Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. {ECO 0000305}. # SUBCELLULAR LOCATION MDTE_ECOLI Cell inner membrane {ECO 0000305}; Lipid- anchor {ECO 0000255|PROSITE-ProRule PRU00303}. # SUBUNIT MDTE_ECOLI Homotrimer. Part of the tripartite efflux system MdtEF- TolC, which is composed of an inner membrane transporter, MdtF, a membrane fusion protein, MdtE, and an outer membrane component, TolC. The complex forms a large protein conduit and can translocate molecules across both the inner and outer membranes. {ECO 0000269|PubMed 11914367, ECO 0000269|PubMed 16079137}. # TCDB 8.A.1.6 the membrane fusion protein (mfp) family # TIGRFAMs TIGR01730 RND_mfp # eggNOG ENOG4105C1P Bacteria # eggNOG ENOG410XNVN LUCA BLAST swissprot:MDTE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MDTE_ECOLI BioCyc ECOL316407:JW3481-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3481-MONOMER BioCyc EcoCyc:EG12240-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12240-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2003.03477.x http://dx.doi.org/10.1046/j.1365-2958.2003.03477.x DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1099/mic.0.26460-0 http://dx.doi.org/10.1099/mic.0.26460-0 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.183.20.5803-5812.2001 http://dx.doi.org/10.1128/JB.183.20.5803-5812.2001 DOI 10.1128/JB.184.22.6225-6234.2002 http://dx.doi.org/10.1128/JB.184.22.6225-6234.2002 DOI 10.1128/JB.184.8.2319-2323.2002 http://dx.doi.org/10.1128/JB.184.8.2319-2323.2002 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2151 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2151 EcoGene EG12240 http://www.ecogene.org/geneInfo.php?eg_id=EG12240 EnsemblBacteria AAC76538 http://www.ensemblgenomes.org/id/AAC76538 EnsemblBacteria AAC76538 http://www.ensemblgenomes.org/id/AAC76538 EnsemblBacteria BAE77781 http://www.ensemblgenomes.org/id/BAE77781 EnsemblBacteria BAE77781 http://www.ensemblgenomes.org/id/BAE77781 EnsemblBacteria BAE77781 http://www.ensemblgenomes.org/id/BAE77781 EnsemblBacteria b3513 http://www.ensemblgenomes.org/id/b3513 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0031226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031226 GO_function GO:0015238 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015238 GO_process GO:0006855 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006855 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 948031 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948031 HOGENOM HOG000158247 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000158247&db=HOGENOM6 InParanoid P37636 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37636 IntAct P37636 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37636* InterPro IPR006143 http://www.ebi.ac.uk/interpro/entry/IPR006143 InterPro IPR032317 http://www.ebi.ac.uk/interpro/entry/IPR032317 KEGG_Gene ecj:JW3481 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3481 KEGG_Gene eco:b3513 http://www.genome.jp/dbget-bin/www_bget?eco:b3513 OMA LQFAGVI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LQFAGVI PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:MDTE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MDTE_ECOLI PSORT-B swissprot:MDTE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MDTE_ECOLI PSORT2 swissprot:MDTE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MDTE_ECOLI Pfam PF00529 http://pfam.xfam.org/family/PF00529 Pfam PF16576 http://pfam.xfam.org/family/PF16576 Phobius swissprot:MDTE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MDTE_ECOLI PhylomeDB P37636 http://phylomedb.org/?seqid=P37636 ProteinModelPortal P37636 http://www.proteinmodelportal.org/query/uniprot/P37636 PubMed 11566977 http://www.ncbi.nlm.nih.gov/pubmed/11566977 PubMed 11914367 http://www.ncbi.nlm.nih.gov/pubmed/11914367 PubMed 12399493 http://www.ncbi.nlm.nih.gov/pubmed/12399493 PubMed 12694615 http://www.ncbi.nlm.nih.gov/pubmed/12694615 PubMed 14523115 http://www.ncbi.nlm.nih.gov/pubmed/14523115 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417970 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417970 RefSeq WP_001081984 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001081984 SMR P37636 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37636 STRING 511145.b3513 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3513&targetmode=cogs TCDB 8.A.1.6 http://www.tcdb.org/search/result.php?tc=8.A.1.6 TIGRFAMs TIGR01730 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01730 UniProtKB MDTE_ECOLI http://www.uniprot.org/uniprot/MDTE_ECOLI UniProtKB-AC P37636 http://www.uniprot.org/uniprot/P37636 charge swissprot:MDTE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MDTE_ECOLI eggNOG ENOG4105C1P http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C1P eggNOG ENOG410XNVN http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNVN epestfind swissprot:MDTE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MDTE_ECOLI garnier swissprot:MDTE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MDTE_ECOLI helixturnhelix swissprot:MDTE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MDTE_ECOLI hmoment swissprot:MDTE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MDTE_ECOLI iep swissprot:MDTE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MDTE_ECOLI inforesidue swissprot:MDTE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MDTE_ECOLI octanol swissprot:MDTE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MDTE_ECOLI pepcoil swissprot:MDTE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MDTE_ECOLI pepdigest swissprot:MDTE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MDTE_ECOLI pepinfo swissprot:MDTE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MDTE_ECOLI pepnet swissprot:MDTE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MDTE_ECOLI pepstats swissprot:MDTE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MDTE_ECOLI pepwheel swissprot:MDTE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MDTE_ECOLI pepwindow swissprot:MDTE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MDTE_ECOLI sigcleave swissprot:MDTE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MDTE_ECOLI ## Database ID URL or Descriptions # AltName Crotonobetainyl-CoA:carnitine CoA-transferase {ECO 0000255|HAMAP-Rule:MF_01050} # BRENDA 2.8.3.21 2026 # BioGrid 4261584 5 # CATALYTIC ACTIVITY CAIB_ECOLI (E)-4-(trimethylammonio)but-2-enoyl-CoA + L- carnitine = (E)-4-(trimethylammonio)but-2-enoate + L-carnitinyl- CoA. {ECO 0000255|HAMAP-Rule MF_01050, ECO 0000269|PubMed 11551212}. # CATALYTIC ACTIVITY CAIB_ECOLI 4-trimethylammoniobutanoyl-CoA + L-carnitine = 4-trimethylammoniobutanoate + L-carnitinyl-CoA. {ECO 0000255|HAMAP-Rule MF_01050, ECO 0000269|PubMed 11551212}. # CAUTION Was originally thought to be an L-carnitine dehydratase. {ECO:0000305|PubMed 8188598}. # EcoGene EG11559 caiB # FUNCTION CAIB_ECOLI Catalyzes the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA to L-carnitine to generate L-carnitinyl- CoA and gamma-butyrobetaine. Is also able to catalyze the reversible transfer of the CoA moiety from gamma-butyrobetainyl- CoA or L-carnitinyl-CoA to crotonobetaine to generate crotonobetainyl-CoA. {ECO 0000255|HAMAP-Rule MF_01050, ECO 0000269|PubMed 11551212}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0008410 CoA-transferase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0008735 carnitine dehydratase activity; EXP:EcoliWiki. # GO_process GO:0042413 carnitine catabolic process; EXP:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.50.10540 -; 2. # HAMAP MF_01050 CaiB # INDUCTION CAIB_ECOLI By L-carnitine or crotonobetaine. # IntAct P31572 12 # InterPro IPR003673 CoA-Trfase_fam_III # InterPro IPR023452 CoA-Trfase_CaiB # InterPro IPR023606 CoA-Trfase_III_dom # KEGG_Brite ko01000 Enzymes # MISCELLANEOUS Some strains of E.coli, such as ATCC 25922, can metabolize carnitine under aerobiosis. {ECO:0000305|PubMed 10339822}. # Organism CAIB_ECOLI Escherichia coli (strain K12) # PATHWAY CAIB_ECOLI Amine and polyamine metabolism; carnitine metabolism. {ECO 0000255|HAMAP-Rule MF_01050, ECO 0000269|PubMed 11551212}. # PATRIC 32115171 VBIEscCol129921_0037 # PDB 1XA3 X-ray; 1.85 A; A/B=2-405 # PDB 1XA4 X-ray; 1.90 A; A/B=2-405 # PDB 1XK6 X-ray; 1.85 A; A/B/C/D=1-405 # PDB 1XK7 X-ray; 1.60 A; A/B/C=1-405 # PDB 1XVT X-ray; 2.30 A; A=1-405 # PDB 1XVU X-ray; 2.40 A; A=1-405 # PDB 1XVV X-ray; 2.40 A; A=1-405 # PIR S40559 S40559 # Pfam PF02515 CoA_transf_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName L-carnitine CoA-transferase {ECO:0000255|HAMAP-Rule MF_01050} # RefSeq NP_414580 NC_000913.3 # RefSeq WP_000349936 NZ_LN832404.1 # SIMILARITY Belongs to the CaiB/BaiF CoA-transferase family. {ECO:0000255|HAMAP-Rule MF_01050, ECO:0000305}. # SUBCELLULAR LOCATION CAIB_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_01050}. # SUBUNIT CAIB_ECOLI Homodimer. {ECO 0000255|HAMAP-Rule MF_01050, ECO 0000269|PubMed 15518548}. # SUPFAM SSF89796 SSF89796 # eggNOG COG1804 LUCA # eggNOG ENOG4105C04 Bacteria BLAST swissprot:CAIB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CAIB_ECOLI BioCyc ECOL316407:JW0037-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0037-MONOMER BioCyc EcoCyc:CARNDEHYDRA-MONOMER http://biocyc.org/getid?id=EcoCyc:CARNDEHYDRA-MONOMER BioCyc MetaCyc:CARNDEHYDRA-MONOMER http://biocyc.org/getid?id=MetaCyc:CARNDEHYDRA-MONOMER COG COG1804 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1804 DOI 10.1021/bi0108812 http://dx.doi.org/10.1021/bi0108812 DOI 10.1021/bi048481c http://dx.doi.org/10.1021/bi048481c DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1111/j.1365-2958.1994.tb00470.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb00470.x DOI 10.1111/j.1574-6968.1999.tb13582.x http://dx.doi.org/10.1111/j.1574-6968.1999.tb13582.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.8.3.21 {ECO:0000255|HAMAP-Rule:MF_01050, ECO:0000269|PubMed:11551212} http://www.genome.jp/dbget-bin/www_bget?EC:2.8.3.21 {ECO:0000255|HAMAP-Rule:MF_01050, ECO:0000269|PubMed:11551212} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X67748 http://www.ebi.ac.uk/ena/data/view/X67748 EMBL X73904 http://www.ebi.ac.uk/ena/data/view/X73904 ENZYME 2.8.3.21 {ECO:0000255|HAMAP-Rule:MF_01050, ECO:0000269|PubMed:11551212} http://enzyme.expasy.org/EC/2.8.3.21 {ECO:0000255|HAMAP-Rule:MF_01050, ECO:0000269|PubMed:11551212} EchoBASE EB1520 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1520 EcoGene EG11559 http://www.ecogene.org/geneInfo.php?eg_id=EG11559 EnsemblBacteria AAC73149 http://www.ensemblgenomes.org/id/AAC73149 EnsemblBacteria AAC73149 http://www.ensemblgenomes.org/id/AAC73149 EnsemblBacteria BAB96607 http://www.ensemblgenomes.org/id/BAB96607 EnsemblBacteria BAB96607 http://www.ensemblgenomes.org/id/BAB96607 EnsemblBacteria BAB96607 http://www.ensemblgenomes.org/id/BAB96607 EnsemblBacteria b0038 http://www.ensemblgenomes.org/id/b0038 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0008410 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008410 GO_function GO:0008735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008735 GO_process GO:0042413 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042413 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.50.10540 http://www.cathdb.info/version/latest/superfamily/3.40.50.10540 GeneID 948997 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948997 HAMAP MF_01050 http://hamap.expasy.org/unirule/MF_01050 HOGENOM HOG000219745 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219745&db=HOGENOM6 InParanoid P31572 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31572 IntAct P31572 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31572* IntEnz 2.8.3.21 {ECO:0000255|HAMAP-Rule:MF_01050, ECO:0000269|PubMed:11551212} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.8.3.21 {ECO:0000255|HAMAP-Rule:MF_01050, ECO:0000269|PubMed:11551212} InterPro IPR003673 http://www.ebi.ac.uk/interpro/entry/IPR003673 InterPro IPR023452 http://www.ebi.ac.uk/interpro/entry/IPR023452 InterPro IPR023606 http://www.ebi.ac.uk/interpro/entry/IPR023606 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0037 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0037 KEGG_Gene eco:b0038 http://www.genome.jp/dbget-bin/www_bget?eco:b0038 KEGG_Orthology KO:K08298 http://www.genome.jp/dbget-bin/www_bget?KO:K08298 OMA VMPKFKN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VMPKFKN PDB 1XA3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1XA3 PDB 1XA4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1XA4 PDB 1XK6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1XK6 PDB 1XK7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1XK7 PDB 1XVT http://www.ebi.ac.uk/pdbe-srv/view/entry/1XVT PDB 1XVU http://www.ebi.ac.uk/pdbe-srv/view/entry/1XVU PDB 1XVV http://www.ebi.ac.uk/pdbe-srv/view/entry/1XVV PDBsum 1XA3 http://www.ebi.ac.uk/pdbsum/1XA3 PDBsum 1XA4 http://www.ebi.ac.uk/pdbsum/1XA4 PDBsum 1XK6 http://www.ebi.ac.uk/pdbsum/1XK6 PDBsum 1XK7 http://www.ebi.ac.uk/pdbsum/1XK7 PDBsum 1XVT http://www.ebi.ac.uk/pdbsum/1XVT PDBsum 1XVU http://www.ebi.ac.uk/pdbsum/1XVU PDBsum 1XVV http://www.ebi.ac.uk/pdbsum/1XVV PSORT swissprot:CAIB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CAIB_ECOLI PSORT-B swissprot:CAIB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CAIB_ECOLI PSORT2 swissprot:CAIB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CAIB_ECOLI Pfam PF02515 http://pfam.xfam.org/family/PF02515 Phobius swissprot:CAIB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CAIB_ECOLI PhylomeDB P31572 http://phylomedb.org/?seqid=P31572 ProteinModelPortal P31572 http://www.proteinmodelportal.org/query/uniprot/P31572 PubMed 10339822 http://www.ncbi.nlm.nih.gov/pubmed/10339822 PubMed 11551212 http://www.ncbi.nlm.nih.gov/pubmed/11551212 PubMed 15518548 http://www.ncbi.nlm.nih.gov/pubmed/15518548 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7815937 http://www.ncbi.nlm.nih.gov/pubmed/7815937 PubMed 8188598 http://www.ncbi.nlm.nih.gov/pubmed/8188598 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414580 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414580 RefSeq WP_000349936 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000349936 SMR P31572 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31572 STRING 511145.b0038 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0038&targetmode=cogs STRING COG1804 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1804&targetmode=cogs SUPFAM SSF89796 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF89796 UniProtKB CAIB_ECOLI http://www.uniprot.org/uniprot/CAIB_ECOLI UniProtKB-AC P31572 http://www.uniprot.org/uniprot/P31572 charge swissprot:CAIB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CAIB_ECOLI eggNOG COG1804 http://eggnogapi.embl.de/nog_data/html/tree/COG1804 eggNOG ENOG4105C04 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C04 epestfind swissprot:CAIB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CAIB_ECOLI garnier swissprot:CAIB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CAIB_ECOLI helixturnhelix swissprot:CAIB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CAIB_ECOLI hmoment swissprot:CAIB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CAIB_ECOLI iep swissprot:CAIB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CAIB_ECOLI inforesidue swissprot:CAIB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CAIB_ECOLI octanol swissprot:CAIB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CAIB_ECOLI pepcoil swissprot:CAIB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CAIB_ECOLI pepdigest swissprot:CAIB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CAIB_ECOLI pepinfo swissprot:CAIB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CAIB_ECOLI pepnet swissprot:CAIB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CAIB_ECOLI pepstats swissprot:CAIB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CAIB_ECOLI pepwheel swissprot:CAIB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CAIB_ECOLI pepwindow swissprot:CAIB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CAIB_ECOLI sigcleave swissprot:CAIB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CAIB_ECOLI ## Database ID URL or Descriptions # BioGrid 4263348 376 # EcoGene EG14375 yeiW # INTERACTION YEIW_ECOLI P45579 ybdH; NbExp=3; IntAct=EBI-8767954, EBI-553586; # IntAct P0AFT8 19 # InterPro IPR005358 Puta_zinc/iron-chelating_dom # Organism YEIW_ECOLI Escherichia coli (strain K12) # PATRIC 32119693 VBIEscCol129921_2257 # Pfam PF03692 CxxCxxCC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEIW_ECOLI UPF0153 protein YeiW # RefSeq WP_000389030 NZ_LN832404.1 # RefSeq YP_588461 NC_000913.3 # SIMILARITY Belongs to the UPF0153 family. {ECO 0000305}. # eggNOG COG0727 LUCA # eggNOG ENOG4105KRS Bacteria BLAST swissprot:YEIW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEIW_ECOLI BioCyc ECOL316407:JW5361-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5361-MONOMER BioCyc EcoCyc:MONOMER0-2726 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2726 COG COG0727 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0727 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14375 http://www.ecogene.org/geneInfo.php?eg_id=EG14375 EnsemblBacteria ABD18689 http://www.ensemblgenomes.org/id/ABD18689 EnsemblBacteria ABD18689 http://www.ensemblgenomes.org/id/ABD18689 EnsemblBacteria BAE76644 http://www.ensemblgenomes.org/id/BAE76644 EnsemblBacteria BAE76644 http://www.ensemblgenomes.org/id/BAE76644 EnsemblBacteria BAE76644 http://www.ensemblgenomes.org/id/BAE76644 EnsemblBacteria b4502 http://www.ensemblgenomes.org/id/b4502 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 4056031 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4056031 HOGENOM HOG000257225 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000257225&db=HOGENOM6 InParanoid P0AFT8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFT8 IntAct P0AFT8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFT8* InterPro IPR005358 http://www.ebi.ac.uk/interpro/entry/IPR005358 KEGG_Gene ecj:JW5361 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5361 KEGG_Gene eco:b4502 http://www.genome.jp/dbget-bin/www_bget?eco:b4502 KEGG_Orthology KO:K06940 http://www.genome.jp/dbget-bin/www_bget?KO:K06940 OMA CIAPSIA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CIAPSIA PSORT swissprot:YEIW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEIW_ECOLI PSORT-B swissprot:YEIW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEIW_ECOLI PSORT2 swissprot:YEIW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEIW_ECOLI Pfam PF03692 http://pfam.xfam.org/family/PF03692 Phobius swissprot:YEIW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEIW_ECOLI PhylomeDB P0AFT8 http://phylomedb.org/?seqid=P0AFT8 ProteinModelPortal P0AFT8 http://www.proteinmodelportal.org/query/uniprot/P0AFT8 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000389030 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000389030 RefSeq YP_588461 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_588461 STRING 511145.b4502 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4502&targetmode=cogs STRING COG0727 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0727&targetmode=cogs UniProtKB YEIW_ECOLI http://www.uniprot.org/uniprot/YEIW_ECOLI UniProtKB-AC P0AFT8 http://www.uniprot.org/uniprot/P0AFT8 charge swissprot:YEIW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEIW_ECOLI eggNOG COG0727 http://eggnogapi.embl.de/nog_data/html/tree/COG0727 eggNOG ENOG4105KRS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KRS epestfind swissprot:YEIW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEIW_ECOLI garnier swissprot:YEIW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEIW_ECOLI helixturnhelix swissprot:YEIW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEIW_ECOLI hmoment swissprot:YEIW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEIW_ECOLI iep swissprot:YEIW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEIW_ECOLI inforesidue swissprot:YEIW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEIW_ECOLI octanol swissprot:YEIW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEIW_ECOLI pepcoil swissprot:YEIW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEIW_ECOLI pepdigest swissprot:YEIW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEIW_ECOLI pepinfo swissprot:YEIW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEIW_ECOLI pepnet swissprot:YEIW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEIW_ECOLI pepstats swissprot:YEIW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEIW_ECOLI pepwheel swissprot:YEIW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEIW_ECOLI pepwindow swissprot:YEIW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEIW_ECOLI sigcleave swissprot:YEIW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEIW_ECOLI ## Database ID URL or Descriptions # BioGrid 4261442 23 # EcoGene EG13103 ygbI # GO_component GO:0005622 intracellular; IEA:InterPro. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; ISS:EcoCyc. # GOslim_component GO:0005622 intracellular # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # InterPro IPR001034 DeoR_HTH # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR014036 DeoR_C # InterPro IPR018356 Tscrpt_reg_HTH_DeoR_CS # Organism YGBI_ECOLI Escherichia coli (strain K12) # PATRIC 32120872 VBIEscCol129921_2828 # PIR C65054 C65054 # PRINTS PR00037 HTHLACR # PROSITE PS00894 HTH_DEOR_1 # PROSITE PS51000 HTH_DEOR_2 # Pfam PF00455 DeoRC # Pfam PF08220 HTH_DeoR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGBI_ECOLI Uncharacterized HTH-type transcriptional regulator YgbI # RefSeq NP_417215 NC_000913.3 # RefSeq WP_001300386 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA69245.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAE76812.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Contains 1 HTH deoR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00349}. # SMART SM00420 HTH_DEOR # SUPFAM SSF46785 SSF46785 # eggNOG COG1349 LUCA # eggNOG ENOG4105MVE Bacteria BLAST swissprot:YGBI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGBI_ECOLI BioCyc ECOL316407:JW2705-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2705-MONOMER BioCyc EcoCyc:G7416-MONOMER http://biocyc.org/getid?id=EcoCyc:G7416-MONOMER DIP DIP-12110N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12110N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EchoBASE EB2906 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2906 EcoGene EG13103 http://www.ecogene.org/geneInfo.php?eg_id=EG13103 EnsemblBacteria AAC75777 http://www.ensemblgenomes.org/id/AAC75777 EnsemblBacteria AAC75777 http://www.ensemblgenomes.org/id/AAC75777 EnsemblBacteria BAE76812 http://www.ensemblgenomes.org/id/BAE76812 EnsemblBacteria BAE76812 http://www.ensemblgenomes.org/id/BAE76812 EnsemblBacteria BAE76812 http://www.ensemblgenomes.org/id/BAE76812 EnsemblBacteria b2735 http://www.ensemblgenomes.org/id/b2735 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 947204 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947204 HOGENOM HOG000224683 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000224683&db=HOGENOM6 InterPro IPR001034 http://www.ebi.ac.uk/interpro/entry/IPR001034 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR014036 http://www.ebi.ac.uk/interpro/entry/IPR014036 InterPro IPR018356 http://www.ebi.ac.uk/interpro/entry/IPR018356 KEGG_Gene ecj:JW2705 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2705 KEGG_Gene eco:b2735 http://www.genome.jp/dbget-bin/www_bget?eco:b2735 PRINTS PR00037 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00037 PROSITE PS00894 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00894 PROSITE PS51000 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51000 PSORT swissprot:YGBI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGBI_ECOLI PSORT-B swissprot:YGBI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGBI_ECOLI PSORT2 swissprot:YGBI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGBI_ECOLI Pfam PF00455 http://pfam.xfam.org/family/PF00455 Pfam PF08220 http://pfam.xfam.org/family/PF08220 Phobius swissprot:YGBI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGBI_ECOLI PhylomeDB P52598 http://phylomedb.org/?seqid=P52598 ProteinModelPortal P52598 http://www.proteinmodelportal.org/query/uniprot/P52598 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417215 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417215 RefSeq WP_001300386 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300386 SMART SM00420 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00420 STRING 511145.b2735 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2735&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB YGBI_ECOLI http://www.uniprot.org/uniprot/YGBI_ECOLI UniProtKB-AC P52598 http://www.uniprot.org/uniprot/P52598 charge swissprot:YGBI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGBI_ECOLI eggNOG COG1349 http://eggnogapi.embl.de/nog_data/html/tree/COG1349 eggNOG ENOG4105MVE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105MVE epestfind swissprot:YGBI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGBI_ECOLI garnier swissprot:YGBI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGBI_ECOLI helixturnhelix swissprot:YGBI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGBI_ECOLI hmoment swissprot:YGBI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGBI_ECOLI iep swissprot:YGBI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGBI_ECOLI inforesidue swissprot:YGBI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGBI_ECOLI octanol swissprot:YGBI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGBI_ECOLI pepcoil swissprot:YGBI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGBI_ECOLI pepdigest swissprot:YGBI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGBI_ECOLI pepinfo swissprot:YGBI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGBI_ECOLI pepnet swissprot:YGBI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGBI_ECOLI pepstats swissprot:YGBI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGBI_ECOLI pepwheel swissprot:YGBI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGBI_ECOLI pepwindow swissprot:YGBI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGBI_ECOLI sigcleave swissprot:YGBI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGBI_ECOLI ## Database ID URL or Descriptions # AltName SURE_ECOLI Exopolyphosphatase # AltName SURE_ECOLI Nucleoside monophosphate phosphohydrolase # AltName SURE_ECOLI Stationary-phase survival protein SurE # BIOPHYSICOCHEMICAL PROPERTIES SURE_ECOLI Kinetic parameters KM=0.32 mM for 5'-AMP {ECO 0000269|PubMed 15489502}; KM=0.26 mM for 5'-GMP {ECO 0000269|PubMed 15489502}; KM=0.28 mM for 5'-dGMP {ECO 0000269|PubMed 15489502}; KM=0.10 mM for 3'-AMP {ECO 0000269|PubMed 15489502}; KM=0.37 mM for 3'-CMP {ECO 0000269|PubMed 15489502}; KM=2.49 mM for pNPP {ECO 0000269|PubMed 15489502}; KM=0.02 mM for polyphosphate {ECO 0000269|PubMed 15489502}; Vmax=10.0 umol/min/mg enzyme with 5'-AMP as substrate {ECO 0000269|PubMed 15489502}; Vmax=22.4 umol/min/mg enzyme with 5'-GMP as substrate {ECO 0000269|PubMed 15489502}; Vmax=16.4 umol/min/mg enzyme with 5'-dGMP as substrate {ECO 0000269|PubMed 15489502}; Vmax=20.1 umol/min/mg enzyme with 3'-AMP as substrate {ECO 0000269|PubMed 15489502}; Vmax=12.1 umol/min/mg enzyme with 3'-CMP as substrate {ECO 0000269|PubMed 15489502}; Vmax=7.24 umol/min/mg enzyme with pNPP as substrate {ECO 0000269|PubMed 15489502}; Vmax=0.10 umol/min/mg enzyme with polyphosphate as substrate {ECO 0000269|PubMed 15489502}; pH dependence Optimum pH is 7.0-7.2 for nucleotidase activity. {ECO 0000269|PubMed 15489502}; # BRENDA 3.1.3 2026 # BRENDA 3.1.3 2026 # BRENDA 3.6.1.11 2026 # BioGrid 4262277 12 # CATALYTIC ACTIVITY SURE_ECOLI (Polyphosphate)(n) + H(2)O = (polyphosphate)(n-1) + phosphate. # CATALYTIC ACTIVITY SURE_ECOLI A 3'-ribonucleotide + H(2)O = a ribonucleoside + phosphate. # CATALYTIC ACTIVITY SURE_ECOLI A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate. # CAUTION Was originally annotated as an acid phosphatase (EC 3.1.3.2). {ECO 0000305}. # COFACTOR SURE_ECOLI Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 15489502}; Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000269|PubMed 15489502}; Name=Ni(2+); Xref=ChEBI CHEBI 49786; Evidence={ECO 0000269|PubMed 15489502}; Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 15489502}; Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 15489502}; Note=Binds 1 divalent metal cation per subunit. Highest nucleotidase activity with Mn(2+), followed by Co(2+), Ni(2+) and Mg(2+). Highest exopolyphosphatase activity with Mg(2+), followed by Co(2+) and Zn(2+). {ECO 0000269|PubMed 15489502}; # ENZYME REGULATION SURE_ECOLI Inhibited by various ribo- or deoxyribonucleoside 5'-triphosphates but is insensitive to nucleoside diphosphates. # EcoGene EG11817 surE # FUNCTION SURE_ECOLI Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'- monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain- length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. Also plays a significant physiological role in stress-response and is required for the survival of E.coli in stationary growth phase. {ECO 0000269|PubMed 15489502}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0000166 nucleotide binding; IEA:UniProtKB-KW. # GO_function GO:0004309 exopolyphosphatase activity; IDA:EcoCyc. # GO_function GO:0008253 5'-nucleotidase activity; IDA:EcoCyc. # GO_function GO:0008254 3'-nucleotidase activity; IDA:EcoCyc. # GO_function GO:0030145 manganese ion binding; IDA:EcoCyc. # GO_process GO:0046050 UMP catabolic process; IGI:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.1210.10 -; 1. # HAMAP MF_00060 SurE # IntAct P0A840 3 # InterPro IPR002828 SurE-like_Pase/nucleotidase # InterPro IPR030048 SurE # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00240 Pyrimidine metabolism # KEGG_Pathway ko00760 Nicotinate and nicotinamide metabolism # Organism SURE_ECOLI Escherichia coli (strain K12) # PATRIC 32120894 VBIEscCol129921_2839 # PIR I69732 I69732 # Pfam PF01975 SurE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SURE_ECOLI 5'/3'-nucleotidase SurE # RefSeq NP_417224 NC_000913.3 # RefSeq WP_001295182 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA69254.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the SurE nucleotidase family. {ECO 0000305}. # SUBCELLULAR LOCATION SURE_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Monomer and homooligomer in solution. The oligomeric complex consists of at least four subunits. {ECO:0000269|PubMed 15489502}. # SUPFAM SSF64167 SSF64167 # TIGRFAMs TIGR00087 surE # eggNOG COG0496 LUCA # eggNOG ENOG4105CV2 Bacteria BLAST swissprot:SURE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SURE_ECOLI BioCyc ECOL316407:JW2714-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2714-MONOMER BioCyc EcoCyc:EG11817-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11817-MONOMER BioCyc MetaCyc:EG11817-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11817-MONOMER COG COG0496 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0496 DIP DIP-47982N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47982N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M411023200 http://dx.doi.org/10.1074/jbc.M411023200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.3.5 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.5 EC_number EC:3.1.3.6 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.6 EC_number EC:3.6.1.11 http://www.genome.jp/dbget-bin/www_bget?EC:3.6.1.11 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L07942 http://www.ebi.ac.uk/ena/data/view/L07942 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 ENZYME 3.1.3.5 http://enzyme.expasy.org/EC/3.1.3.5 ENZYME 3.1.3.6 http://enzyme.expasy.org/EC/3.1.3.6 ENZYME 3.6.1.11 http://enzyme.expasy.org/EC/3.6.1.11 EchoBASE EB1764 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1764 EcoGene EG11817 http://www.ecogene.org/geneInfo.php?eg_id=EG11817 EnsemblBacteria AAC75786 http://www.ensemblgenomes.org/id/AAC75786 EnsemblBacteria AAC75786 http://www.ensemblgenomes.org/id/AAC75786 EnsemblBacteria BAE76821 http://www.ensemblgenomes.org/id/BAE76821 EnsemblBacteria BAE76821 http://www.ensemblgenomes.org/id/BAE76821 EnsemblBacteria BAE76821 http://www.ensemblgenomes.org/id/BAE76821 EnsemblBacteria b2744 http://www.ensemblgenomes.org/id/b2744 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000166 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000166 GO_function GO:0004309 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004309 GO_function GO:0008253 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008253 GO_function GO:0008254 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008254 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_process GO:0046050 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046050 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.1210.10 http://www.cathdb.info/version/latest/superfamily/3.40.1210.10 GeneID 947211 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947211 HAMAP MF_00060 http://hamap.expasy.org/unirule/MF_00060 HOGENOM HOG000122500 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122500&db=HOGENOM6 InParanoid P0A840 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A840 IntAct P0A840 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A840* IntEnz 3.1.3.5 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.5 IntEnz 3.1.3.6 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.6 IntEnz 3.6.1.11 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.1.11 InterPro IPR002828 http://www.ebi.ac.uk/interpro/entry/IPR002828 InterPro IPR030048 http://www.ebi.ac.uk/interpro/entry/IPR030048 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2714 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2714 KEGG_Gene eco:b2744 http://www.genome.jp/dbget-bin/www_bget?eco:b2744 KEGG_Orthology KO:K03787 http://www.genome.jp/dbget-bin/www_bget?KO:K03787 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Pathway ko00760 http://www.genome.jp/kegg-bin/show_pathway?ko00760 KEGG_Reaction rn:R00183 http://www.genome.jp/dbget-bin/www_bget?rn:R00183 KEGG_Reaction rn:R00511 http://www.genome.jp/dbget-bin/www_bget?rn:R00511 KEGG_Reaction rn:R00963 http://www.genome.jp/dbget-bin/www_bget?rn:R00963 KEGG_Reaction rn:R01126 http://www.genome.jp/dbget-bin/www_bget?rn:R01126 KEGG_Reaction rn:R01227 http://www.genome.jp/dbget-bin/www_bget?rn:R01227 KEGG_Reaction rn:R01569 http://www.genome.jp/dbget-bin/www_bget?rn:R01569 KEGG_Reaction rn:R01664 http://www.genome.jp/dbget-bin/www_bget?rn:R01664 KEGG_Reaction rn:R01968 http://www.genome.jp/dbget-bin/www_bget?rn:R01968 KEGG_Reaction rn:R02088 http://www.genome.jp/dbget-bin/www_bget?rn:R02088 KEGG_Reaction rn:R02323 http://www.genome.jp/dbget-bin/www_bget?rn:R02323 KEGG_Reaction rn:R02719 http://www.genome.jp/dbget-bin/www_bget?rn:R02719 KEGG_Reaction rn:R03346 http://www.genome.jp/dbget-bin/www_bget?rn:R03346 OMA ANGFYYV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ANGFYYV PSORT swissprot:SURE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SURE_ECOLI PSORT-B swissprot:SURE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SURE_ECOLI PSORT2 swissprot:SURE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SURE_ECOLI Pfam PF01975 http://pfam.xfam.org/family/PF01975 Phobius swissprot:SURE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SURE_ECOLI PhylomeDB P0A840 http://phylomedb.org/?seqid=P0A840 ProteinModelPortal P0A840 http://www.proteinmodelportal.org/query/uniprot/P0A840 PubMed 15489502 http://www.ncbi.nlm.nih.gov/pubmed/15489502 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7928962 http://www.ncbi.nlm.nih.gov/pubmed/7928962 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417224 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417224 RefSeq WP_001295182 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295182 SMR P0A840 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A840 STRING 511145.b2744 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2744&targetmode=cogs STRING COG0496 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0496&targetmode=cogs SUPFAM SSF64167 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF64167 TIGRFAMs TIGR00087 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00087 UniProtKB SURE_ECOLI http://www.uniprot.org/uniprot/SURE_ECOLI UniProtKB-AC P0A840 http://www.uniprot.org/uniprot/P0A840 charge swissprot:SURE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SURE_ECOLI eggNOG COG0496 http://eggnogapi.embl.de/nog_data/html/tree/COG0496 eggNOG ENOG4105CV2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CV2 epestfind swissprot:SURE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SURE_ECOLI garnier swissprot:SURE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SURE_ECOLI helixturnhelix swissprot:SURE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SURE_ECOLI hmoment swissprot:SURE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SURE_ECOLI iep swissprot:SURE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SURE_ECOLI inforesidue swissprot:SURE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SURE_ECOLI octanol swissprot:SURE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SURE_ECOLI pepcoil swissprot:SURE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SURE_ECOLI pepdigest swissprot:SURE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SURE_ECOLI pepinfo swissprot:SURE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SURE_ECOLI pepnet swissprot:SURE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SURE_ECOLI pepstats swissprot:SURE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SURE_ECOLI pepwheel swissprot:SURE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SURE_ECOLI pepwindow swissprot:SURE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SURE_ECOLI sigcleave swissprot:SURE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SURE_ECOLI ## Database ID URL or Descriptions # BioGrid 4260201 10 # EcoGene EG13778 yncH # InterPro IPR020099 Uncharacterised_YncH # Organism YNCH_ECOLI Escherichia coli (strain K12) # PATRIC 32118202 VBIEscCol129921_1521 # PIR B64898 B64898 # ProDom PD055765 Uncharacterised_YncH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNCH_ECOLI Uncharacterized protein YncH # RefSeq NP_415972 NC_000913.3 # RefSeq WP_000226995 NZ_LN832404.1 BLAST swissprot:YNCH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNCH_ECOLI BioCyc ECOL316407:JW5235-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5235-MONOMER BioCyc EcoCyc:G6766-MONOMER http://biocyc.org/getid?id=EcoCyc:G6766-MONOMER DIP DIP-12752N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12752N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3540 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3540 EcoGene EG13778 http://www.ecogene.org/geneInfo.php?eg_id=EG13778 EnsemblBacteria AAC74537 http://www.ensemblgenomes.org/id/AAC74537 EnsemblBacteria AAC74537 http://www.ensemblgenomes.org/id/AAC74537 EnsemblBacteria BAE76447 http://www.ensemblgenomes.org/id/BAE76447 EnsemblBacteria BAE76447 http://www.ensemblgenomes.org/id/BAE76447 EnsemblBacteria BAE76447 http://www.ensemblgenomes.org/id/BAE76447 EnsemblBacteria b1455 http://www.ensemblgenomes.org/id/b1455 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946024 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946024 HOGENOM HOG000050874 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000050874&db=HOGENOM6 InterPro IPR020099 http://www.ebi.ac.uk/interpro/entry/IPR020099 KEGG_Gene ecj:JW5235 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5235 KEGG_Gene eco:b1455 http://www.genome.jp/dbget-bin/www_bget?eco:b1455 OMA NANKNIR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NANKNIR PSORT swissprot:YNCH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNCH_ECOLI PSORT-B swissprot:YNCH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNCH_ECOLI PSORT2 swissprot:YNCH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNCH_ECOLI Phobius swissprot:YNCH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNCH_ECOLI ProteinModelPortal P76118 http://www.proteinmodelportal.org/query/uniprot/P76118 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415972 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415972 RefSeq WP_000226995 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000226995 STRING 511145.b1455 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1455&targetmode=cogs UniProtKB YNCH_ECOLI http://www.uniprot.org/uniprot/YNCH_ECOLI UniProtKB-AC P76118 http://www.uniprot.org/uniprot/P76118 charge swissprot:YNCH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNCH_ECOLI epestfind swissprot:YNCH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNCH_ECOLI garnier swissprot:YNCH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNCH_ECOLI helixturnhelix swissprot:YNCH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNCH_ECOLI hmoment swissprot:YNCH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNCH_ECOLI iep swissprot:YNCH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNCH_ECOLI inforesidue swissprot:YNCH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNCH_ECOLI octanol swissprot:YNCH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNCH_ECOLI pepcoil swissprot:YNCH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNCH_ECOLI pepdigest swissprot:YNCH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNCH_ECOLI pepinfo swissprot:YNCH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNCH_ECOLI pepnet swissprot:YNCH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNCH_ECOLI pepstats swissprot:YNCH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNCH_ECOLI pepwheel swissprot:YNCH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNCH_ECOLI pepwindow swissprot:YNCH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNCH_ECOLI sigcleave swissprot:YNCH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNCH_ECOLI ## Database ID URL or Descriptions # AltName INTB_ECOLI Int(P4) # AltName INTB_ECOLI Putative prophage P4 integrase # BioGrid 4262732 18 # CAUTION Additional homology to the integrase family exists upstream of the current start codon. {ECO 0000305}. # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG12364 intB # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008979 prophage integrase activity; IBA:GO_Central. # GO_function GO:0043565 sequence-specific DNA binding; IBA:GO_Central. # GO_process GO:0006310 DNA recombination; IEA:UniProtKB-KW. # GO_process GO:0032359 provirus excision; IBA:GO_Central. # GO_process GO:0046718 viral entry into host cell; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0044403 symbiosis, encompassing mutualism through parasitism # Gene3D 1.10.150.130 -; 1. # Gene3D 1.10.443.10 -; 1. # IntAct P39347 15 # InterPro IPR002104 Integrase_catalytic # InterPro IPR011010 DNA_brk_join_enz # InterPro IPR013762 Integrase-like_cat # InterPro IPR023109 Integrase_recombinase_N # InterPro IPR025166 DUF4102 # Organism INTB_ECOLI Escherichia coli (strain K12) # PATRIC 48668107 VBIEscCol107702_4305 # PIR S56496 S56496 # Pfam PF00589 Phage_integrase # Pfam PF13356 DUF4102 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Putative protein IntB {ECO 0000305} # RefSeq WP_000550469 NZ_LN832404.1 # SIMILARITY Belongs to the 'phage' integrase family. {ECO 0000305}. # SUPFAM SSF56349 SSF56349 # eggNOG COG0582 LUCA BLAST swissprot:INTB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INTB_ECOLI BioCyc ECOL316407:JW4227-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4227-MONOMER BioCyc EcoCyc:EG12364-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12364-MONOMER DIP DIP-10035N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10035N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M96355 http://www.ebi.ac.uk/ena/data/view/M96355 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2267 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2267 EcoGene EG12364 http://www.ecogene.org/geneInfo.php?eg_id=EG12364 EnsemblBacteria BAE78267 http://www.ensemblgenomes.org/id/BAE78267 EnsemblBacteria BAE78267 http://www.ensemblgenomes.org/id/BAE78267 EnsemblBacteria BAE78267 http://www.ensemblgenomes.org/id/BAE78267 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008979 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0032359 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032359 GO_process GO:0046718 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046718 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0044403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403 Gene3D 1.10.150.130 http://www.cathdb.info/version/latest/superfamily/1.10.150.130 Gene3D 1.10.443.10 http://www.cathdb.info/version/latest/superfamily/1.10.443.10 HOGENOM HOG000263105 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000263105&db=HOGENOM6 InParanoid P39347 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39347 IntAct P39347 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39347* InterPro IPR002104 http://www.ebi.ac.uk/interpro/entry/IPR002104 InterPro IPR011010 http://www.ebi.ac.uk/interpro/entry/IPR011010 InterPro IPR013762 http://www.ebi.ac.uk/interpro/entry/IPR013762 InterPro IPR023109 http://www.ebi.ac.uk/interpro/entry/IPR023109 InterPro IPR025166 http://www.ebi.ac.uk/interpro/entry/IPR025166 KEGG_Gene ecj:JW4227 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4227 OMA WSEEHAN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WSEEHAN PSORT swissprot:INTB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INTB_ECOLI PSORT-B swissprot:INTB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INTB_ECOLI PSORT2 swissprot:INTB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INTB_ECOLI Pfam PF00589 http://pfam.xfam.org/family/PF00589 Pfam PF13356 http://pfam.xfam.org/family/PF13356 Phobius swissprot:INTB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INTB_ECOLI PhylomeDB P39347 http://phylomedb.org/?seqid=P39347 ProteinModelPortal P39347 http://www.proteinmodelportal.org/query/uniprot/P39347 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000550469 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000550469 SMR P39347 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39347 STRING 316407.85677017 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85677017&targetmode=cogs SUPFAM SSF56349 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56349 UniProtKB INTB_ECOLI http://www.uniprot.org/uniprot/INTB_ECOLI UniProtKB-AC P39347 http://www.uniprot.org/uniprot/P39347 charge swissprot:INTB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INTB_ECOLI eggNOG COG0582 http://eggnogapi.embl.de/nog_data/html/tree/COG0582 epestfind swissprot:INTB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INTB_ECOLI garnier swissprot:INTB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INTB_ECOLI helixturnhelix swissprot:INTB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INTB_ECOLI hmoment swissprot:INTB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INTB_ECOLI iep swissprot:INTB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INTB_ECOLI inforesidue swissprot:INTB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INTB_ECOLI octanol swissprot:INTB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INTB_ECOLI pepcoil swissprot:INTB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INTB_ECOLI pepdigest swissprot:INTB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INTB_ECOLI pepinfo swissprot:INTB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INTB_ECOLI pepnet swissprot:INTB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INTB_ECOLI pepstats swissprot:INTB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INTB_ECOLI pepwheel swissprot:INTB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INTB_ECOLI pepwindow swissprot:INTB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INTB_ECOLI sigcleave swissprot:INTB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INTB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260820 20 # EcoGene EG13839 ynfA # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # HAMAP MF_00010 UPF0060 # InterPro IPR003844 UPF0060 # KEGG_Brite ko02000 Transporters # Organism YNFA_ECOLI Escherichia coli (strain K12) # PATRIC 32118466 VBIEscCol129921_1653 # PIR H64913 H64913 # Pfam PF02694 UPF0060 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UPF0060 membrane protein YnfA {ECO:0000255|HAMAP-Rule MF_00010} # RefSeq NP_416099 NC_000913.3 # RefSeq WP_000598292 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0060 family. {ECO:0000255|HAMAP- Rule MF_00010}. # SUBCELLULAR LOCATION YNFA_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_00010, ECO 0000269|PubMed 11867724, ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255|HAMAP-Rule MF_00010, ECO 0000269|PubMed 11867724, ECO 0000269|PubMed 15919996}. # TCDB 2.A.7.26 the drug/metabolite transporter (dmt) superfamily # eggNOG COG1742 LUCA # eggNOG ENOG4105KK4 Bacteria BLAST swissprot:YNFA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNFA_ECOLI BioCyc ECOL316407:JW1574-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1574-MONOMER BioCyc EcoCyc:G6840-MONOMER http://biocyc.org/getid?id=EcoCyc:G6840-MONOMER COG COG1742 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1742 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.052018199 http://dx.doi.org/10.1073/pnas.052018199 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3600 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3600 EcoGene EG13839 http://www.ecogene.org/geneInfo.php?eg_id=EG13839 EnsemblBacteria AAC74654 http://www.ensemblgenomes.org/id/AAC74654 EnsemblBacteria AAC74654 http://www.ensemblgenomes.org/id/AAC74654 EnsemblBacteria BAE76476 http://www.ensemblgenomes.org/id/BAE76476 EnsemblBacteria BAE76476 http://www.ensemblgenomes.org/id/BAE76476 EnsemblBacteria BAE76476 http://www.ensemblgenomes.org/id/BAE76476 EnsemblBacteria b1582 http://www.ensemblgenomes.org/id/b1582 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 946125 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946125 HAMAP MF_00010 http://hamap.expasy.org/unirule/MF_00010 HOGENOM HOG000223633 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000223633&db=HOGENOM6 InParanoid P76169 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76169 InterPro IPR003844 http://www.ebi.ac.uk/interpro/entry/IPR003844 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1574 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1574 KEGG_Gene eco:b1582 http://www.genome.jp/dbget-bin/www_bget?eco:b1582 KEGG_Orthology KO:K09771 http://www.genome.jp/dbget-bin/www_bget?KO:K09771 OMA TPDLYDW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TPDLYDW PSORT swissprot:YNFA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNFA_ECOLI PSORT-B swissprot:YNFA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNFA_ECOLI PSORT2 swissprot:YNFA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNFA_ECOLI Pfam PF02694 http://pfam.xfam.org/family/PF02694 Phobius swissprot:YNFA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNFA_ECOLI PhylomeDB P76169 http://phylomedb.org/?seqid=P76169 ProteinModelPortal P76169 http://www.proteinmodelportal.org/query/uniprot/P76169 PubMed 11867724 http://www.ncbi.nlm.nih.gov/pubmed/11867724 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416099 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416099 RefSeq WP_000598292 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000598292 STRING 511145.b1582 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1582&targetmode=cogs STRING COG1742 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1742&targetmode=cogs TCDB 2.A.7.26 http://www.tcdb.org/search/result.php?tc=2.A.7.26 UniProtKB YNFA_ECOLI http://www.uniprot.org/uniprot/YNFA_ECOLI UniProtKB-AC P76169 http://www.uniprot.org/uniprot/P76169 charge swissprot:YNFA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNFA_ECOLI eggNOG COG1742 http://eggnogapi.embl.de/nog_data/html/tree/COG1742 eggNOG ENOG4105KK4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KK4 epestfind swissprot:YNFA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNFA_ECOLI garnier swissprot:YNFA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNFA_ECOLI helixturnhelix swissprot:YNFA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNFA_ECOLI hmoment swissprot:YNFA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNFA_ECOLI iep swissprot:YNFA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNFA_ECOLI inforesidue swissprot:YNFA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNFA_ECOLI octanol swissprot:YNFA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNFA_ECOLI pepcoil swissprot:YNFA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNFA_ECOLI pepdigest swissprot:YNFA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNFA_ECOLI pepinfo swissprot:YNFA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNFA_ECOLI pepnet swissprot:YNFA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNFA_ECOLI pepstats swissprot:YNFA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNFA_ECOLI pepwheel swissprot:YNFA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNFA_ECOLI pepwindow swissprot:YNFA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNFA_ECOLI sigcleave swissprot:YNFA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNFA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260055 21 # DISRUPTION PHENOTYPE PGAD_ECOLI Cells lacking this gene do not synthesize PGA. {ECO 0000269|PubMed 15090514, ECO 0000269|PubMed 18359807}. # EcoGene EG13862 pgaD # FUNCTION PGAD_ECOLI Required for the synthesis of poly-beta-1,6-N-acetyl-D- glucosamine (PGA), a biofilm adhesin polysaccharide. May assist the glycosyltransferase PgaC in the polymerization of PGA. {ECO 0000269|PubMed 15090514, ECO 0000269|PubMed 18359807, ECO 0000269|PubMed 19460094}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0043708 cell adhesion involved in biofilm formation; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0007155 cell adhesion # INDUCTION Levels of this protein are positively controlled by the second messenger c-di-GMP (at protein level) at a post- transcriptional level. Increased levels of c-di-GMP lead to increased levels of PgaD. {ECO:0000269|PubMed 19460094}. # INTERACTION PGAD_ECOLI P25522 mnmE; NbExp=3; IntAct=EBI-562069, EBI-550986; P75905 pgaC; NbExp=2; IntAct=EBI-562069, EBI-561450; # IntAct P69432 7 # InterPro IPR023829 PGA_PgaD # Organism PGAD_ECOLI Escherichia coli (strain K12) # PATRIC 32117275 VBIEscCol129921_1061 # PIR C64844 C64844 # Pfam PF13994 PgaD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PGAD_ECOLI Biofilm PGA synthesis protein PgaD # RefSeq NP_415540 NC_000913.3 # RefSeq WP_001061095 NZ_LN832404.1 # SUBCELLULAR LOCATION PGAD_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # TIGRFAMs TIGR03940 PGA_PgaD BLAST swissprot:PGAD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PGAD_ECOLI BioCyc ECOL316407:JW1006-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1006-MONOMER BioCyc EcoCyc:G6528-MONOMER http://biocyc.org/getid?id=EcoCyc:G6528-MONOMER BioCyc MetaCyc:G6528-MONOMER http://biocyc.org/getid?id=MetaCyc:G6528-MONOMER DIP DIP-48114N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48114N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.2009.06739.x http://dx.doi.org/10.1111/j.1365-2958.2009.06739.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01920-07 http://dx.doi.org/10.1128/JB.01920-07 DOI 10.1128/JB.186.9.2724-2734.2004 http://dx.doi.org/10.1128/JB.186.9.2724-2734.2004 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3622 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3622 EcoGene EG13862 http://www.ecogene.org/geneInfo.php?eg_id=EG13862 EnsemblBacteria AAC74106 http://www.ensemblgenomes.org/id/AAC74106 EnsemblBacteria AAC74106 http://www.ensemblgenomes.org/id/AAC74106 EnsemblBacteria BAA35802 http://www.ensemblgenomes.org/id/BAA35802 EnsemblBacteria BAA35802 http://www.ensemblgenomes.org/id/BAA35802 EnsemblBacteria BAA35802 http://www.ensemblgenomes.org/id/BAA35802 EnsemblBacteria b1021 http://www.ensemblgenomes.org/id/b1021 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0043708 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043708 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GeneID 947503 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947503 HOGENOM HOG000118885 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118885&db=HOGENOM6 IntAct P69432 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69432* InterPro IPR023829 http://www.ebi.ac.uk/interpro/entry/IPR023829 KEGG_Gene ecj:JW1006 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1006 KEGG_Gene eco:b1021 http://www.genome.jp/dbget-bin/www_bget?eco:b1021 KEGG_Orthology KO:K11937 http://www.genome.jp/dbget-bin/www_bget?KO:K11937 OMA KKQQHHA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KKQQHHA PSORT swissprot:PGAD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PGAD_ECOLI PSORT-B swissprot:PGAD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PGAD_ECOLI PSORT2 swissprot:PGAD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PGAD_ECOLI Pfam PF13994 http://pfam.xfam.org/family/PF13994 Phobius swissprot:PGAD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PGAD_ECOLI ProteinModelPortal P69432 http://www.proteinmodelportal.org/query/uniprot/P69432 PubMed 15090514 http://www.ncbi.nlm.nih.gov/pubmed/15090514 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18359807 http://www.ncbi.nlm.nih.gov/pubmed/18359807 PubMed 19460094 http://www.ncbi.nlm.nih.gov/pubmed/19460094 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415540 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415540 RefSeq WP_001061095 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001061095 STRING 511145.b1021 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1021&targetmode=cogs TIGRFAMs TIGR03940 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03940 UniProtKB PGAD_ECOLI http://www.uniprot.org/uniprot/PGAD_ECOLI UniProtKB-AC P69432 http://www.uniprot.org/uniprot/P69432 charge swissprot:PGAD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PGAD_ECOLI epestfind swissprot:PGAD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PGAD_ECOLI garnier swissprot:PGAD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PGAD_ECOLI helixturnhelix swissprot:PGAD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PGAD_ECOLI hmoment swissprot:PGAD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PGAD_ECOLI iep swissprot:PGAD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PGAD_ECOLI inforesidue swissprot:PGAD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PGAD_ECOLI octanol swissprot:PGAD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PGAD_ECOLI pepcoil swissprot:PGAD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PGAD_ECOLI pepdigest swissprot:PGAD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PGAD_ECOLI pepinfo swissprot:PGAD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PGAD_ECOLI pepnet swissprot:PGAD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PGAD_ECOLI pepstats swissprot:PGAD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PGAD_ECOLI pepwheel swissprot:PGAD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PGAD_ECOLI pepwindow swissprot:PGAD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PGAD_ECOLI sigcleave swissprot:PGAD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PGAD_ECOLI ## Database ID URL or Descriptions # AltName COBU_ECOLI Adenosylcobinamide kinase # AltName COBU_ECOLI Adenosylcobinamide-phosphate guanylyltransferase # BioGrid 4262116 18 # CATALYTIC ACTIVITY ATP or GTP + adenosylcobinamide = adenosylcobinamide phosphate + ADP or GDP. {ECO:0000250|UniProtKB Q05599}. # CATALYTIC ACTIVITY GTP + adenosylcobinamide phosphate = diphosphate + adenosylcobinamide-GDP. {ECO:0000250|UniProtKB Q05599}. # CDD cd00544 CobU # EcoGene EG13238 cobU # FUNCTION COBU_ECOLI Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. {ECO 0000250|UniProtKB Q05599}. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0005525 GTP binding; IEA:UniProtKB-KW. # GO_function GO:0008819 cobinamide kinase activity; ISS:EcoCyc. # GO_function GO:0008820 cobinamide phosphate guanylyltransferase activity; ISS:EcoCyc. # GO_function GO:0043752 adenosylcobinamide kinase activity; IEA:UniProtKB-EC. # GO_process GO:0006779 porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0009236 cobalamin biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.300 -; 1. # INDUCTION COBU_ECOLI By cobinamide. # IntAct P0AE76 4 # InterPro IPR003203 Cobinamide_kinase/P_G-Trfase # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00860 Porphyrin and chlorophyll metabolism # Organism COBU_ECOLI Escherichia coli (strain K12) # PATHWAY Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide step 5/7. # PATHWAY Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide step 6/7. # PATRIC 32119317 VBIEscCol129921_2068 # PIR H64963 H64963 # PIRSF PIRSF006135 CobU # Pfam PF02283 CobU # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName COBU_ECOLI Bifunctional adenosylcobalamin biosynthesis protein CobU # RefSeq NP_416497 NC_000913.3 # RefSeq WP_000973176 NZ_LN832404.1 # SIMILARITY Belongs to the CobU/CobP family. {ECO 0000305}. # SUBUNIT Homodimer. {ECO 0000250}. # SUPFAM SSF52540 SSF52540 # UniPathway UPA00148 UER00236 # UniPathway UPA00148 UER00237 # eggNOG COG2087 LUCA # eggNOG ENOG4108YZT Bacteria BLAST swissprot:COBU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:COBU_ECOLI BioCyc ECOL316407:JW1971-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1971-MONOMER BioCyc EcoCyc:COBU-MONOMER http://biocyc.org/getid?id=EcoCyc:COBU-MONOMER COG COG2087 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2087 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.156 {ECO:0000250|UniProtKB:Q05599} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.156 {ECO:0000250|UniProtKB:Q05599} EC_number EC:2.7.7.62 {ECO:0000250|UniProtKB:Q05599} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.62 {ECO:0000250|UniProtKB:Q05599} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U33333 http://www.ebi.ac.uk/ena/data/view/U33333 ENZYME 2.7.1.156 {ECO:0000250|UniProtKB:Q05599} http://enzyme.expasy.org/EC/2.7.1.156 {ECO:0000250|UniProtKB:Q05599} ENZYME 2.7.7.62 {ECO:0000250|UniProtKB:Q05599} http://enzyme.expasy.org/EC/2.7.7.62 {ECO:0000250|UniProtKB:Q05599} EchoBASE EB3027 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3027 EcoGene EG13238 http://www.ecogene.org/geneInfo.php?eg_id=EG13238 EnsemblBacteria AAC75054 http://www.ensemblgenomes.org/id/AAC75054 EnsemblBacteria AAC75054 http://www.ensemblgenomes.org/id/AAC75054 EnsemblBacteria BAA15810 http://www.ensemblgenomes.org/id/BAA15810 EnsemblBacteria BAA15810 http://www.ensemblgenomes.org/id/BAA15810 EnsemblBacteria BAA15810 http://www.ensemblgenomes.org/id/BAA15810 EnsemblBacteria b1993 http://www.ensemblgenomes.org/id/b1993 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_function GO:0008819 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008819 GO_function GO:0008820 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008820 GO_function GO:0043752 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043752 GO_process GO:0006779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006779 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0009236 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009236 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 946519 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946519 HOGENOM HOG000286613 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000286613&db=HOGENOM6 InParanoid P0AE76 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AE76 IntAct P0AE76 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AE76* IntEnz 2.7.1.156 {ECO:0000250|UniProtKB:Q05599} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.156 {ECO:0000250|UniProtKB:Q05599} IntEnz 2.7.7.62 {ECO:0000250|UniProtKB:Q05599} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.62 {ECO:0000250|UniProtKB:Q05599} InterPro IPR003203 http://www.ebi.ac.uk/interpro/entry/IPR003203 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1971 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1971 KEGG_Gene eco:b1993 http://www.genome.jp/dbget-bin/www_bget?eco:b1993 KEGG_Orthology KO:K02231 http://www.genome.jp/dbget-bin/www_bget?KO:K02231 KEGG_Pathway ko00860 http://www.genome.jp/kegg-bin/show_pathway?ko00860 KEGG_Reaction rn:R05221 http://www.genome.jp/dbget-bin/www_bget?rn:R05221 KEGG_Reaction rn:R05222 http://www.genome.jp/dbget-bin/www_bget?rn:R05222 KEGG_Reaction rn:R06558 http://www.genome.jp/dbget-bin/www_bget?rn:R06558 OMA LWLTNHL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LWLTNHL PSORT swissprot:COBU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:COBU_ECOLI PSORT-B swissprot:COBU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:COBU_ECOLI PSORT2 swissprot:COBU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:COBU_ECOLI Pfam PF02283 http://pfam.xfam.org/family/PF02283 Phobius swissprot:COBU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:COBU_ECOLI PhylomeDB P0AE76 http://phylomedb.org/?seqid=P0AE76 ProteinModelPortal P0AE76 http://www.proteinmodelportal.org/query/uniprot/P0AE76 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7592411 http://www.ncbi.nlm.nih.gov/pubmed/7592411 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416497 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416497 RefSeq WP_000973176 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000973176 SMR P0AE76 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AE76 STRING 511145.b1993 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1993&targetmode=cogs STRING COG2087 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2087&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB COBU_ECOLI http://www.uniprot.org/uniprot/COBU_ECOLI UniProtKB-AC P0AE76 http://www.uniprot.org/uniprot/P0AE76 charge swissprot:COBU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:COBU_ECOLI eggNOG COG2087 http://eggnogapi.embl.de/nog_data/html/tree/COG2087 eggNOG ENOG4108YZT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108YZT epestfind swissprot:COBU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:COBU_ECOLI garnier swissprot:COBU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:COBU_ECOLI helixturnhelix swissprot:COBU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:COBU_ECOLI hmoment swissprot:COBU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:COBU_ECOLI iep swissprot:COBU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:COBU_ECOLI inforesidue swissprot:COBU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:COBU_ECOLI octanol swissprot:COBU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:COBU_ECOLI pepcoil swissprot:COBU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:COBU_ECOLI pepdigest swissprot:COBU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:COBU_ECOLI pepinfo swissprot:COBU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:COBU_ECOLI pepnet swissprot:COBU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:COBU_ECOLI pepstats swissprot:COBU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:COBU_ECOLI pepwheel swissprot:COBU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:COBU_ECOLI pepwindow swissprot:COBU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:COBU_ECOLI sigcleave swissprot:COBU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:COBU_ECOLI ## Database ID URL or Descriptions # EcoGene EG12295 yibN # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # Gene3D 3.40.250.10 -; 1. # IntAct P0AG27 2 # InterPro IPR001763 Rhodanese-like_dom # Organism YIBN_ECOLI Escherichia coli (strain K12) # PATRIC 32122707 VBIEscCol129921_3730 # PIR S47832 S47832 # PROSITE PS50206 RHODANESE_3 # Pfam PF00581 Rhodanese # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIBN_ECOLI Uncharacterized protein YibN # RefSeq NP_418068 NC_000913.3 # RefSeq WP_001156181 NZ_LN832404.1 # SIMILARITY Contains 1 rhodanese domain. {ECO:0000255|PROSITE- ProRule PRU00173}. # SMART SM00450 RHOD # SUPFAM SSF52821 SSF52821 # eggNOG COG0607 LUCA # eggNOG ENOG4107YZP Bacteria BLAST swissprot:YIBN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIBN_ECOLI BioCyc ECOL316407:JW3586-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3586-MONOMER BioCyc EcoCyc:EG12295-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12295-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2203 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2203 EcoGene EG12295 http://www.ecogene.org/geneInfo.php?eg_id=EG12295 EnsemblBacteria AAC76635 http://www.ensemblgenomes.org/id/AAC76635 EnsemblBacteria AAC76635 http://www.ensemblgenomes.org/id/AAC76635 EnsemblBacteria BAE77681 http://www.ensemblgenomes.org/id/BAE77681 EnsemblBacteria BAE77681 http://www.ensemblgenomes.org/id/BAE77681 EnsemblBacteria BAE77681 http://www.ensemblgenomes.org/id/BAE77681 EnsemblBacteria b3611 http://www.ensemblgenomes.org/id/b3611 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 Gene3D 3.40.250.10 http://www.cathdb.info/version/latest/superfamily/3.40.250.10 GeneID 948131 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948131 HOGENOM HOG000247776 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000247776&db=HOGENOM6 InParanoid P0AG27 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AG27 IntAct P0AG27 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AG27* InterPro IPR001763 http://www.ebi.ac.uk/interpro/entry/IPR001763 KEGG_Gene ecj:JW3586 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3586 KEGG_Gene eco:b3611 http://www.genome.jp/dbget-bin/www_bget?eco:b3611 OMA EIMQFVS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EIMQFVS PROSITE PS50206 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50206 PSORT swissprot:YIBN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIBN_ECOLI PSORT-B swissprot:YIBN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIBN_ECOLI PSORT2 swissprot:YIBN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIBN_ECOLI Pfam PF00581 http://pfam.xfam.org/family/PF00581 Phobius swissprot:YIBN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIBN_ECOLI PhylomeDB P0AG27 http://phylomedb.org/?seqid=P0AG27 ProteinModelPortal P0AG27 http://www.proteinmodelportal.org/query/uniprot/P0AG27 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418068 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418068 RefSeq WP_001156181 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001156181 SMART SM00450 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00450 SMR P0AG27 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AG27 STRING 511145.b3611 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3611&targetmode=cogs SUPFAM SSF52821 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52821 UniProtKB YIBN_ECOLI http://www.uniprot.org/uniprot/YIBN_ECOLI UniProtKB-AC P0AG27 http://www.uniprot.org/uniprot/P0AG27 charge swissprot:YIBN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIBN_ECOLI eggNOG COG0607 http://eggnogapi.embl.de/nog_data/html/tree/COG0607 eggNOG ENOG4107YZP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107YZP epestfind swissprot:YIBN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIBN_ECOLI garnier swissprot:YIBN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIBN_ECOLI helixturnhelix swissprot:YIBN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIBN_ECOLI hmoment swissprot:YIBN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIBN_ECOLI iep swissprot:YIBN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIBN_ECOLI inforesidue swissprot:YIBN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIBN_ECOLI octanol swissprot:YIBN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIBN_ECOLI pepcoil swissprot:YIBN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIBN_ECOLI pepdigest swissprot:YIBN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIBN_ECOLI pepinfo swissprot:YIBN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIBN_ECOLI pepnet swissprot:YIBN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIBN_ECOLI pepstats swissprot:YIBN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIBN_ECOLI pepwheel swissprot:YIBN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIBN_ECOLI pepwindow swissprot:YIBN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIBN_ECOLI sigcleave swissprot:YIBN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIBN_ECOLI ## Database ID URL or Descriptions # BioGrid 4259632 10 # EcoGene EG13931 ydgJ # GO_function GO:0016491 oxidoreductase activity; IBA:GO_Central. # GO_process GO:0055114 oxidation-reduction process; IBA:GO_Central. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.720 -; 1. # IntAct P77376 3 # InterPro IPR000683 Oxidoreductase_N # InterPro IPR004104 OxRdtase_C # InterPro IPR016040 NAD(P)-bd_dom # Organism YDGJ_ECOLI Escherichia coli (strain K12) # PATRIC 32118550 VBIEscCol129921_1695 # PIR B64919 B64919 # Pfam PF01408 GFO_IDH_MocA # Pfam PF02894 GFO_IDH_MocA_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDGJ_ECOLI Uncharacterized oxidoreductase YdgJ # RefSeq NP_416141 NC_000913.3 # RefSeq WP_001282550 NZ_LN832404.1 # SIMILARITY Belongs to the Gfo/Idh/MocA family. {ECO 0000305}. # SUPFAM SSF51735 SSF51735 # eggNOG COG0673 LUCA # eggNOG ENOG4105D9R Bacteria BLAST swissprot:YDGJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDGJ_ECOLI BioCyc ECOL316407:JW5265-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5265-MONOMER BioCyc EcoCyc:G6868-MONOMER http://biocyc.org/getid?id=EcoCyc:G6868-MONOMER DIP DIP-11718N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11718N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- EchoBASE EB3690 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3690 EcoGene EG13931 http://www.ecogene.org/geneInfo.php?eg_id=EG13931 EnsemblBacteria AAC74696 http://www.ensemblgenomes.org/id/AAC74696 EnsemblBacteria AAC74696 http://www.ensemblgenomes.org/id/AAC74696 EnsemblBacteria BAA15375 http://www.ensemblgenomes.org/id/BAA15375 EnsemblBacteria BAA15375 http://www.ensemblgenomes.org/id/BAA15375 EnsemblBacteria BAA15375 http://www.ensemblgenomes.org/id/BAA15375 EnsemblBacteria b1624 http://www.ensemblgenomes.org/id/b1624 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_process GO:0055114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 947164 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947164 HOGENOM HOG000227438 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000227438&db=HOGENOM6 InParanoid P77376 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77376 IntAct P77376 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77376* IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR000683 http://www.ebi.ac.uk/interpro/entry/IPR000683 InterPro IPR004104 http://www.ebi.ac.uk/interpro/entry/IPR004104 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 KEGG_Gene ecj:JW5265 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5265 KEGG_Gene eco:b1624 http://www.genome.jp/dbget-bin/www_bget?eco:b1624 OMA RFERWRP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RFERWRP PSORT swissprot:YDGJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDGJ_ECOLI PSORT-B swissprot:YDGJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDGJ_ECOLI PSORT2 swissprot:YDGJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDGJ_ECOLI Pfam PF01408 http://pfam.xfam.org/family/PF01408 Pfam PF02894 http://pfam.xfam.org/family/PF02894 Phobius swissprot:YDGJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDGJ_ECOLI PhylomeDB P77376 http://phylomedb.org/?seqid=P77376 ProteinModelPortal P77376 http://www.proteinmodelportal.org/query/uniprot/P77376 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416141 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416141 RefSeq WP_001282550 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001282550 SMR P77376 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77376 STRING 511145.b1624 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1624&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB YDGJ_ECOLI http://www.uniprot.org/uniprot/YDGJ_ECOLI UniProtKB-AC P77376 http://www.uniprot.org/uniprot/P77376 charge swissprot:YDGJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDGJ_ECOLI eggNOG COG0673 http://eggnogapi.embl.de/nog_data/html/tree/COG0673 eggNOG ENOG4105D9R http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D9R epestfind swissprot:YDGJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDGJ_ECOLI garnier swissprot:YDGJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDGJ_ECOLI helixturnhelix swissprot:YDGJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDGJ_ECOLI hmoment swissprot:YDGJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDGJ_ECOLI iep swissprot:YDGJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDGJ_ECOLI inforesidue swissprot:YDGJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDGJ_ECOLI octanol swissprot:YDGJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDGJ_ECOLI pepcoil swissprot:YDGJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDGJ_ECOLI pepdigest swissprot:YDGJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDGJ_ECOLI pepinfo swissprot:YDGJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDGJ_ECOLI pepnet swissprot:YDGJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDGJ_ECOLI pepstats swissprot:YDGJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDGJ_ECOLI pepwheel swissprot:YDGJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDGJ_ECOLI pepwindow swissprot:YDGJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDGJ_ECOLI sigcleave swissprot:YDGJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDGJ_ECOLI ## Database ID URL or Descriptions # AltName DHG_ECOLI Glucose dehydrogenase [pyrroloquinoline-quinone] # BioGrid 4261958 8 # CATALYTIC ACTIVITY DHG_ECOLI D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol. # CDD cd10280 PQQ_mGDH # COFACTOR Name=pyrroloquinoline quinone; Xref=ChEBI:CHEBI 58442; # EcoGene EG10369 gcd # FUNCTION DHG_ECOLI GDH is probably involved in energy conservation rather than in sugar metabolism. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IDA:EcoCyc. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IEA:InterPro. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0008876 quinoprotein glucose dehydrogenase activity; IDA:EcoCyc. # GO_function GO:0048039 ubiquinone binding; IDA:EcoCyc. # GO_function GO:0070968 pyrroloquinoline quinone binding; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # Gene3D 2.140.10.10 -; 2. # IntAct P15877 9 # InterPro IPR001479 Quinoprotein_DH_CS # InterPro IPR002372 PQQ_repeat # InterPro IPR011047 Quinoprotein_ADH-like_supfam # InterPro IPR017511 PQQ_mDH # InterPro IPR018391 PQQ_beta_propeller_repeat # InterPro IPR027295 Quinoprotein_ADH-like_fam # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00030 Pentose phosphate pathway # Organism DHG_ECOLI Escherichia coli (strain K12) # PANTHER PTHR32303:SF4 PTHR32303:SF4; 2 # PATRIC 32115351 VBIEscCol129921_0127 # PIR D64735 JV0107 # PROSITE PS00363 BACTERIAL_PQQ_1 # PROSITE PS00364 BACTERIAL_PQQ_2 # Pfam PF01011 PQQ; 6 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DHG_ECOLI Quinoprotein glucose dehydrogenase # RefSeq NP_414666 NC_000913.3 # RefSeq WP_001306211 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial PQQ dehydrogenase family. {ECO 0000305}. # SMART SM00564 PQQ; 6 # SUBCELLULAR LOCATION DHG_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 16079137}; Multi- pass membrane protein {ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 16079137}; Periplasmic side {ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 16079137}. # SUBUNIT DHG_ECOLI Monomer. # SUPFAM SSF50998 SSF50998; 2 # TIGRFAMs TIGR03074 PQQ_membr_DH # eggNOG COG4993 LUCA # eggNOG ENOG4105DZG Bacteria BLAST swissprot:DHG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DHG_ECOLI BioCyc ECOL316407:JW0120-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0120-MONOMER BioCyc EcoCyc:GLUCDEHYDROG-MONOMER http://biocyc.org/getid?id=EcoCyc:GLUCDEHYDROG-MONOMER BioCyc MetaCyc:GLUCDEHYDROG-MONOMER http://biocyc.org/getid?id=MetaCyc:GLUCDEHYDROG-MONOMER COG COG4993 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4993 DIP DIP-9747N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9747N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj3120679 http://dx.doi.org/10.1042/bj3120679 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.5.2 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.5.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D12651 http://www.ebi.ac.uk/ena/data/view/D12651 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X51323 http://www.ebi.ac.uk/ena/data/view/X51323 ENZYME 1.1.5.2 http://enzyme.expasy.org/EC/1.1.5.2 EchoBASE EB0364 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0364 EcoGene EG10369 http://www.ecogene.org/geneInfo.php?eg_id=EG10369 EnsemblBacteria AAC73235 http://www.ensemblgenomes.org/id/AAC73235 EnsemblBacteria AAC73235 http://www.ensemblgenomes.org/id/AAC73235 EnsemblBacteria BAB96699 http://www.ensemblgenomes.org/id/BAB96699 EnsemblBacteria BAB96699 http://www.ensemblgenomes.org/id/BAB96699 EnsemblBacteria BAB96699 http://www.ensemblgenomes.org/id/BAB96699 EnsemblBacteria b0124 http://www.ensemblgenomes.org/id/b0124 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0008876 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008876 GO_function GO:0048039 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048039 GO_function GO:0070968 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070968 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 2.140.10.10 http://www.cathdb.info/version/latest/superfamily/2.140.10.10 GeneID 944830 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944830 HOGENOM HOG000116843 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000116843&db=HOGENOM6 InParanoid P15877 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P15877 IntAct P15877 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P15877* IntEnz 1.1.5.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.5.2 InterPro IPR001479 http://www.ebi.ac.uk/interpro/entry/IPR001479 InterPro IPR002372 http://www.ebi.ac.uk/interpro/entry/IPR002372 InterPro IPR011047 http://www.ebi.ac.uk/interpro/entry/IPR011047 InterPro IPR017511 http://www.ebi.ac.uk/interpro/entry/IPR017511 InterPro IPR018391 http://www.ebi.ac.uk/interpro/entry/IPR018391 InterPro IPR027295 http://www.ebi.ac.uk/interpro/entry/IPR027295 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0120 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0120 KEGG_Gene eco:b0124 http://www.genome.jp/dbget-bin/www_bget?eco:b0124 KEGG_Orthology KO:K00117 http://www.genome.jp/dbget-bin/www_bget?KO:K00117 KEGG_Pathway ko00030 http://www.genome.jp/kegg-bin/show_pathway?ko00030 KEGG_Reaction rn:R06620 http://www.genome.jp/dbget-bin/www_bget?rn:R06620 MINT MINT-1267882 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1267882 OMA DVGETTY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DVGETTY PANTHER PTHR32303:SF4 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32303:SF4 PROSITE PS00363 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00363 PROSITE PS00364 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00364 PSORT swissprot:DHG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DHG_ECOLI PSORT-B swissprot:DHG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DHG_ECOLI PSORT2 swissprot:DHG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DHG_ECOLI Pfam PF01011 http://pfam.xfam.org/family/PF01011 Phobius swissprot:DHG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DHG_ECOLI PhylomeDB P15877 http://phylomedb.org/?seqid=P15877 ProteinModelPortal P15877 http://www.proteinmodelportal.org/query/uniprot/P15877 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2228962 http://www.ncbi.nlm.nih.gov/pubmed/2228962 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 8419307 http://www.ncbi.nlm.nih.gov/pubmed/8419307 PubMed 8509415 http://www.ncbi.nlm.nih.gov/pubmed/8509415 PubMed 8554505 http://www.ncbi.nlm.nih.gov/pubmed/8554505 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414666 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414666 RefSeq WP_001306211 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001306211 SMART SM00564 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00564 STRING 511145.b0124 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0124&targetmode=cogs STRING COG4993 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4993&targetmode=cogs SUPFAM SSF50998 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50998 TIGRFAMs TIGR03074 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03074 UniProtKB DHG_ECOLI http://www.uniprot.org/uniprot/DHG_ECOLI UniProtKB-AC P15877 http://www.uniprot.org/uniprot/P15877 charge swissprot:DHG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DHG_ECOLI eggNOG COG4993 http://eggnogapi.embl.de/nog_data/html/tree/COG4993 eggNOG ENOG4105DZG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DZG epestfind swissprot:DHG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DHG_ECOLI garnier swissprot:DHG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DHG_ECOLI helixturnhelix swissprot:DHG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DHG_ECOLI hmoment swissprot:DHG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DHG_ECOLI iep swissprot:DHG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DHG_ECOLI inforesidue swissprot:DHG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DHG_ECOLI octanol swissprot:DHG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DHG_ECOLI pepcoil swissprot:DHG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DHG_ECOLI pepdigest swissprot:DHG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DHG_ECOLI pepinfo swissprot:DHG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DHG_ECOLI pepnet swissprot:DHG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DHG_ECOLI pepstats swissprot:DHG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DHG_ECOLI pepwheel swissprot:DHG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DHG_ECOLI pepwindow swissprot:DHG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DHG_ECOLI sigcleave swissprot:DHG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DHG_ECOLI ## Database ID URL or Descriptions # EcoGene EG13444 ycfZ # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR007621 TPM_dom # Organism YCFZ_ECOLI Escherichia coli (strain K12) # PATRIC 32117489 VBIEscCol129921_1167 # PIR F64856 F64856 # Pfam PF04536 TPM_phosphatase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCFZ_ECOLI Inner membrane protein YcfZ # RefSeq NP_415639 NC_000913.3 # RefSeq WP_000713462 NZ_LN832404.1 # SUBCELLULAR LOCATION YCFZ_ECOLI Cell inner membrane; Multi-pass membrane protein. BLAST swissprot:YCFZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCFZ_ECOLI BioCyc ECOL316407:JW1107-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1107-MONOMER BioCyc EcoCyc:G6578-MONOMER http://biocyc.org/getid?id=EcoCyc:G6578-MONOMER DIP DIP-11549N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11549N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3218 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3218 EcoGene EG13444 http://www.ecogene.org/geneInfo.php?eg_id=EG13444 EnsemblBacteria AAC74205 http://www.ensemblgenomes.org/id/AAC74205 EnsemblBacteria AAC74205 http://www.ensemblgenomes.org/id/AAC74205 EnsemblBacteria BAA35941 http://www.ensemblgenomes.org/id/BAA35941 EnsemblBacteria BAA35941 http://www.ensemblgenomes.org/id/BAA35941 EnsemblBacteria BAA35941 http://www.ensemblgenomes.org/id/BAA35941 EnsemblBacteria b1121 http://www.ensemblgenomes.org/id/b1121 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 945685 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945685 HOGENOM HOG000119096 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000119096&db=HOGENOM6 IntAct P75961 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75961* InterPro IPR007621 http://www.ebi.ac.uk/interpro/entry/IPR007621 KEGG_Gene ecj:JW1107 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1107 KEGG_Gene eco:b1121 http://www.genome.jp/dbget-bin/www_bget?eco:b1121 OMA FRQNGKA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FRQNGKA PSORT swissprot:YCFZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCFZ_ECOLI PSORT-B swissprot:YCFZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCFZ_ECOLI PSORT2 swissprot:YCFZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCFZ_ECOLI Pfam PF04536 http://pfam.xfam.org/family/PF04536 Phobius swissprot:YCFZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCFZ_ECOLI ProteinModelPortal P75961 http://www.proteinmodelportal.org/query/uniprot/P75961 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415639 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415639 RefSeq WP_000713462 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000713462 SMR P75961 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75961 STRING 511145.b1121 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1121&targetmode=cogs UniProtKB YCFZ_ECOLI http://www.uniprot.org/uniprot/YCFZ_ECOLI UniProtKB-AC P75961 http://www.uniprot.org/uniprot/P75961 charge swissprot:YCFZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCFZ_ECOLI epestfind swissprot:YCFZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCFZ_ECOLI garnier swissprot:YCFZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCFZ_ECOLI helixturnhelix swissprot:YCFZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCFZ_ECOLI hmoment swissprot:YCFZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCFZ_ECOLI iep swissprot:YCFZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCFZ_ECOLI inforesidue swissprot:YCFZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCFZ_ECOLI octanol swissprot:YCFZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCFZ_ECOLI pepcoil swissprot:YCFZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCFZ_ECOLI pepdigest swissprot:YCFZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCFZ_ECOLI pepinfo swissprot:YCFZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCFZ_ECOLI pepnet swissprot:YCFZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCFZ_ECOLI pepstats swissprot:YCFZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCFZ_ECOLI pepwheel swissprot:YCFZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCFZ_ECOLI pepwindow swissprot:YCFZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCFZ_ECOLI sigcleave swissprot:YCFZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCFZ_ECOLI ## Database ID URL or Descriptions # BioGrid 4261305 16 # EcoGene EG12373 ygdH # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds; IBA:GO_Central. # GO_process GO:0009691 cytokinin biosynthetic process; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.30.1850.10 -; 1. # IntAct P0ADR8 4 # InterPro IPR021826 DUF3412 # InterPro IPR027820 DUF4478 # InterPro IPR031100 LOG_fam # Organism YGDH_ECOLI Escherichia coli (strain K12) # PATRIC 32121006 VBIEscCol129921_2895 # PIR G65061 G65061 # Pfam PF03641 Lysine_decarbox # Pfam PF11892 DUF3412 # Pfam PF14793 DUF4478 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGDH_ECOLI LOG family protein YgdH # RefSeq NP_417275 NC_000913.3 # RefSeq WP_000627995 NZ_LN832404.1 # SIMILARITY Belongs to the LOG family. {ECO 0000305}. # eggNOG COG1611 LUCA # eggNOG ENOG4105EWT Bacteria BLAST swissprot:YGDH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGDH_ECOLI BioCyc ECOL316407:JW2766-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2766-MONOMER BioCyc EcoCyc:EG12373-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12373-MONOMER COG COG1611 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1611 DIP DIP-47955N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47955N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U01233 http://www.ebi.ac.uk/ena/data/view/U01233 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 EchoBASE EB2276 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2276 EcoGene EG12373 http://www.ecogene.org/geneInfo.php?eg_id=EG12373 EnsemblBacteria AAC75837 http://www.ensemblgenomes.org/id/AAC75837 EnsemblBacteria AAC75837 http://www.ensemblgenomes.org/id/AAC75837 EnsemblBacteria BAE76867 http://www.ensemblgenomes.org/id/BAE76867 EnsemblBacteria BAE76867 http://www.ensemblgenomes.org/id/BAE76867 EnsemblBacteria BAE76867 http://www.ensemblgenomes.org/id/BAE76867 EnsemblBacteria b2795 http://www.ensemblgenomes.org/id/b2795 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0016799 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016799 GO_process GO:0009691 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009691 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.30.1850.10 http://www.cathdb.info/version/latest/superfamily/3.30.1850.10 GeneID 947266 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947266 HOGENOM HOG000273722 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000273722&db=HOGENOM6 InParanoid P0ADR8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADR8 IntAct P0ADR8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADR8* InterPro IPR021826 http://www.ebi.ac.uk/interpro/entry/IPR021826 InterPro IPR027820 http://www.ebi.ac.uk/interpro/entry/IPR027820 InterPro IPR031100 http://www.ebi.ac.uk/interpro/entry/IPR031100 KEGG_Gene ecj:JW2766 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2766 KEGG_Gene eco:b2795 http://www.genome.jp/dbget-bin/www_bget?eco:b2795 KEGG_Orthology KO:K06966 http://www.genome.jp/dbget-bin/www_bget?KO:K06966 MINT MINT-1293384 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1293384 OMA EYKYTKK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EYKYTKK PSORT swissprot:YGDH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGDH_ECOLI PSORT-B swissprot:YGDH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGDH_ECOLI PSORT2 swissprot:YGDH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGDH_ECOLI Pfam PF03641 http://pfam.xfam.org/family/PF03641 Pfam PF11892 http://pfam.xfam.org/family/PF11892 Pfam PF14793 http://pfam.xfam.org/family/PF14793 Phobius swissprot:YGDH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGDH_ECOLI ProteinModelPortal P0ADR8 http://www.proteinmodelportal.org/query/uniprot/P0ADR8 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417275 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417275 RefSeq WP_000627995 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000627995 SMR P0ADR8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADR8 STRING 511145.b2795 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2795&targetmode=cogs STRING COG1611 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1611&targetmode=cogs UniProtKB YGDH_ECOLI http://www.uniprot.org/uniprot/YGDH_ECOLI UniProtKB-AC P0ADR8 http://www.uniprot.org/uniprot/P0ADR8 charge swissprot:YGDH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGDH_ECOLI eggNOG COG1611 http://eggnogapi.embl.de/nog_data/html/tree/COG1611 eggNOG ENOG4105EWT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EWT epestfind swissprot:YGDH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGDH_ECOLI garnier swissprot:YGDH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGDH_ECOLI helixturnhelix swissprot:YGDH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGDH_ECOLI hmoment swissprot:YGDH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGDH_ECOLI iep swissprot:YGDH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGDH_ECOLI inforesidue swissprot:YGDH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGDH_ECOLI octanol swissprot:YGDH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGDH_ECOLI pepcoil swissprot:YGDH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGDH_ECOLI pepdigest swissprot:YGDH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGDH_ECOLI pepinfo swissprot:YGDH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGDH_ECOLI pepnet swissprot:YGDH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGDH_ECOLI pepstats swissprot:YGDH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGDH_ECOLI pepwheel swissprot:YGDH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGDH_ECOLI pepwindow swissprot:YGDH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGDH_ECOLI sigcleave swissprot:YGDH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGDH_ECOLI ## Database ID URL or Descriptions # AltName Guanine insertion enzyme {ECO:0000255|HAMAP-Rule MF_00168} # AltName tRNA-guanine transglycosylase {ECO:0000255|HAMAP-Rule MF_00168} # BIOPHYSICOCHEMICAL PROPERTIES TGT_ECOLI Kinetic parameters KM=0.12 uM for tRNA(Tyr) {ECO 0000269|PubMed 11714265}; KM=0.1 uM for guanine {ECO 0000269|PubMed 11714265}; Note=kcat is 0.00121 sec(-1) with tRNA(Tyr) and guanine as substrates. {ECO 0000269|PubMed 11714265}; # BRENDA 2.4.2.29 2026 # BioGrid 4263531 9 # CATALYTIC ACTIVITY TGT_ECOLI Guanine(34) in tRNA + 7-aminomethyl-7- carbaguanine = 7-aminomethyl-7-carbaguanine(34) in tRNA + guanine. {ECO 0000255|HAMAP-Rule MF_00168, ECO 0000269|PubMed 11714265, ECO 0000269|PubMed 12909636}. # COFACTOR TGT_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000255|HAMAP-Rule MF_00168, ECO 0000269|PubMed 7893665}; Note=Binds 1 zinc ion per subunit. {ECO 0000255|HAMAP- Rule MF_00168, ECO 0000269|PubMed 7893665}; # EcoGene EG10996 tgt # FUNCTION TGT_ECOLI Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). {ECO 0000255|HAMAP-Rule MF_00168, ECO 0000269|PubMed 11714265, ECO 0000269|PubMed 12909636}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_function GO:0008479 queuine tRNA-ribosyltransferase activity; IDA:EcoCyc. # GO_process GO:0002099 tRNA wobble guanine modification; IMP:EcoCyc. # GO_process GO:0008616 queuosine biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.105 -; 1. # HAMAP MF_00168 Q_tRNA_Tgt # IntAct P0A847 39 # InterPro IPR002616 tRNA_ribo_trans-like # InterPro IPR004803 Queuine_tRNA-ribosylTrfase # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # Organism TGT_ECOLI Escherichia coli (strain K12) # PATHWAY TGT_ECOLI tRNA modification; tRNA-queuosine biosynthesis. {ECO 0000255|HAMAP-Rule MF_00168, ECO 0000305|PubMed 1706703}. # PATRIC 32115961 VBIEscCol129921_0422 # PIR C38530 C38530 # Pfam PF01702 TGT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Queuine tRNA-ribosyltransferase {ECO:0000255|HAMAP-Rule MF_00168} # RefSeq NP_414940 NC_000913.3 # RefSeq WP_000667319 NZ_LN832404.1 # SIMILARITY Belongs to the queuine tRNA-ribosyltransferase family. {ECO:0000255|HAMAP-Rule MF_00168}. # SUBUNIT Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1. {ECO:0000255|HAMAP-Rule MF_00168}. # SUPFAM SSF51713 SSF51713 # TIGRFAMs TIGR00430 Q_tRNA_tgt # TIGRFAMs TIGR00449 tgt_general # eggNOG COG0343 LUCA # eggNOG ENOG4105C6U Bacteria BLAST swissprot:TGT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TGT_ECOLI BioCyc ECOL316407:JW0396-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0396-MONOMER BioCyc EcoCyc:EG10996-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10996-MONOMER BioCyc MetaCyc:EG10996-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10996-MONOMER COG COG0343 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0343 DIP DIP-36020N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36020N DOI 10.1006/jmbi.1993.1296 http://dx.doi.org/10.1006/jmbi.1993.1296 DOI 10.1021/bi00011a026 http://dx.doi.org/10.1021/bi00011a026 DOI 10.1021/bi00189a004 http://dx.doi.org/10.1021/bi00189a004 DOI 10.1021/bi0110589 http://dx.doi.org/10.1021/bi0110589 DOI 10.1023/A:1026334726357 http://dx.doi.org/10.1023/A:1026334726357 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M304323200 http://dx.doi.org/10.1074/jbc.M304323200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.4.2.29 {ECO:0000255|HAMAP-Rule:MF_00168, ECO:0000269|PubMed:11714265, ECO:0000269|PubMed:12909636} http://www.genome.jp/dbget-bin/www_bget?EC:2.4.2.29 {ECO:0000255|HAMAP-Rule:MF_00168, ECO:0000269|PubMed:11714265, ECO:0000269|PubMed:12909636} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M63939 http://www.ebi.ac.uk/ena/data/view/M63939 EMBL S68715 http://www.ebi.ac.uk/ena/data/view/S68715 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL X56175 http://www.ebi.ac.uk/ena/data/view/X56175 EMBL X56175 http://www.ebi.ac.uk/ena/data/view/X56175 ENZYME 2.4.2.29 {ECO:0000255|HAMAP-Rule:MF_00168, ECO:0000269|PubMed:11714265, ECO:0000269|PubMed:12909636} http://enzyme.expasy.org/EC/2.4.2.29 {ECO:0000255|HAMAP-Rule:MF_00168, ECO:0000269|PubMed:11714265, ECO:0000269|PubMed:12909636} EchoBASE EB0989 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0989 EcoGene EG10996 http://www.ecogene.org/geneInfo.php?eg_id=EG10996 EnsemblBacteria AAC73509 http://www.ensemblgenomes.org/id/AAC73509 EnsemblBacteria AAC73509 http://www.ensemblgenomes.org/id/AAC73509 EnsemblBacteria BAE76186 http://www.ensemblgenomes.org/id/BAE76186 EnsemblBacteria BAE76186 http://www.ensemblgenomes.org/id/BAE76186 EnsemblBacteria BAE76186 http://www.ensemblgenomes.org/id/BAE76186 EnsemblBacteria b0406 http://www.ensemblgenomes.org/id/b0406 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0008479 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008479 GO_process GO:0002099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002099 GO_process GO:0008616 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008616 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.105 http://www.cathdb.info/version/latest/superfamily/3.20.20.105 GeneID 949130 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949130 HAMAP MF_00168 http://hamap.expasy.org/unirule/MF_00168 HOGENOM HOG000223473 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000223473&db=HOGENOM6 InParanoid P0A847 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A847 IntAct P0A847 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A847* IntEnz 2.4.2.29 {ECO:0000255|HAMAP-Rule:MF_00168, ECO:0000269|PubMed:11714265, ECO:0000269|PubMed:12909636} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.2.29 {ECO:0000255|HAMAP-Rule:MF_00168, ECO:0000269|PubMed:11714265, ECO:0000269|PubMed:12909636} InterPro IPR002616 http://www.ebi.ac.uk/interpro/entry/IPR002616 InterPro IPR004803 http://www.ebi.ac.uk/interpro/entry/IPR004803 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW0396 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0396 KEGG_Gene eco:b0406 http://www.genome.jp/dbget-bin/www_bget?eco:b0406 KEGG_Orthology KO:K00773 http://www.genome.jp/dbget-bin/www_bget?KO:K00773 MINT MINT-1219658 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1219658 OMA GIDLFDC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GIDLFDC PSORT swissprot:TGT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TGT_ECOLI PSORT-B swissprot:TGT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TGT_ECOLI PSORT2 swissprot:TGT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TGT_ECOLI Pfam PF01702 http://pfam.xfam.org/family/PF01702 Phobius swissprot:TGT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TGT_ECOLI PhylomeDB P0A847 http://phylomedb.org/?seqid=P0A847 ProteinModelPortal P0A847 http://www.proteinmodelportal.org/query/uniprot/P0A847 PubMed 11714265 http://www.ncbi.nlm.nih.gov/pubmed/11714265 PubMed 12909636 http://www.ncbi.nlm.nih.gov/pubmed/12909636 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1706703 http://www.ncbi.nlm.nih.gov/pubmed/1706703 PubMed 2170107 http://www.ncbi.nlm.nih.gov/pubmed/2170107 PubMed 2249673 http://www.ncbi.nlm.nih.gov/pubmed/2249673 PubMed 7507921 http://www.ncbi.nlm.nih.gov/pubmed/7507921 PubMed 7893665 http://www.ncbi.nlm.nih.gov/pubmed/7893665 PubMed 8003468 http://www.ncbi.nlm.nih.gov/pubmed/8003468 PubMed 8323579 http://www.ncbi.nlm.nih.gov/pubmed/8323579 PubMed 9055203 http://www.ncbi.nlm.nih.gov/pubmed/9055203 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414940 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414940 RefSeq WP_000667319 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000667319 SMR P0A847 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A847 STRING 511145.b0406 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0406&targetmode=cogs STRING COG0343 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0343&targetmode=cogs SUPFAM SSF51713 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51713 TIGRFAMs TIGR00430 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00430 TIGRFAMs TIGR00449 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00449 UniProtKB TGT_ECOLI http://www.uniprot.org/uniprot/TGT_ECOLI UniProtKB-AC P0A847 http://www.uniprot.org/uniprot/P0A847 charge swissprot:TGT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TGT_ECOLI eggNOG COG0343 http://eggnogapi.embl.de/nog_data/html/tree/COG0343 eggNOG ENOG4105C6U http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C6U epestfind swissprot:TGT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TGT_ECOLI garnier swissprot:TGT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TGT_ECOLI helixturnhelix swissprot:TGT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TGT_ECOLI hmoment swissprot:TGT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TGT_ECOLI iep swissprot:TGT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TGT_ECOLI inforesidue swissprot:TGT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TGT_ECOLI octanol swissprot:TGT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TGT_ECOLI pepcoil swissprot:TGT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TGT_ECOLI pepdigest swissprot:TGT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TGT_ECOLI pepinfo swissprot:TGT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TGT_ECOLI pepnet swissprot:TGT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TGT_ECOLI pepstats swissprot:TGT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TGT_ECOLI pepwheel swissprot:TGT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TGT_ECOLI pepwindow swissprot:TGT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TGT_ECOLI sigcleave swissprot:TGT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TGT_ECOLI ## Database ID URL or Descriptions # BioGrid 4261304 486 # CDD cd03020 DsbA_DsbC_DsbG # EcoGene EG11070 dsbC # FUNCTION DSBC_ECOLI Acts as a disulfide isomerase, interacting with incorrectly folded proteins to correct non-native disulfide bonds. DsbG and DsbC are part of a periplasmic reducing system that controls the level of cysteine sulfenylation, and provides reducing equivalents to rescue oxidatively damaged secreted proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbC is reoxidized by DsbD. {ECO 0000269|PubMed 19965429}. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_component GO:0042597 periplasmic space; IDA:EcoliWiki. # GO_function GO:0003756 protein disulfide isomerase activity; IDA:EcoCyc. # GO_function GO:0015035 protein disulfide oxidoreductase activity; IMP:UniProtKB. # GO_process GO:0045454 cell redox homeostasis; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0042592 homeostatic process # Gene3D 3.10.450.70 -; 1. # Gene3D 3.40.30.10 -; 1. # IntAct P0AEG6 9 # InterPro IPR009094 DiS-bond_isomerase_DsbC_N # InterPro IPR012336 Thioredoxin-like_fold # InterPro IPR013766 Thioredoxin_domain # InterPro IPR017937 Thioredoxin_CS # InterPro IPR018950 DiS-bond_isomerase_DsbC/G_N # InterPro IPR033954 DiS-bond_Isoase_DsbC/G # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02044 Secretion system # KEGG_Brite ko03110 Chaperones and folding catalysts # Organism DSBC_ECOLI Escherichia coli (strain K12) # PATRIC 32121198 VBIEscCol129921_2987 # PDB 1EEJ X-ray; 1.90 A; A/B=21-236 # PDB 1G0T X-ray; 2.60 A; A/B=21-236 # PDB 1JZD X-ray; 2.30 A; A/B=20-236 # PDB 1JZO X-ray; 1.92 A; A/B=21-236 # PDB 1TJD X-ray; 2.50 A; A=21-236 # PDB 2IYJ X-ray; 2.00 A; A/B=19-91 # PIR E65073 E65073 # PROSITE PS00194 THIOREDOXIN_1 # PROSITE PS51352 THIOREDOXIN_2 # Pfam PF10411 DsbC_N # Pfam PF13098 Thioredoxin_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Thiol disulfide interchange protein DsbC # RefSeq NP_417369 NC_000913.3 # RefSeq WP_000715214 NZ_LN832404.1 # SIMILARITY Belongs to the thioredoxin family. DsbC subfamily. {ECO 0000305}. # SIMILARITY Contains 1 thioredoxin domain. {ECO:0000255|PROSITE- ProRule PRU00691}. # SUBCELLULAR LOCATION DSBC_ECOLI Periplasm {ECO 0000269|PubMed 8168498}. # SUBUNIT DSBC_ECOLI Homodimer. # SUPFAM SSF52833 SSF52833 # SUPFAM SSF54423 SSF54423 # eggNOG COG1651 LUCA # eggNOG ENOG4105T95 Bacteria BLAST swissprot:DSBC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DSBC_ECOLI BioCyc ECOL316407:JW2861-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2861-MONOMER BioCyc EcoCyc:DSBC-MONOMER http://biocyc.org/getid?id=EcoCyc:DSBC-MONOMER BioCyc MetaCyc:DSBC-MONOMER http://biocyc.org/getid?id=MetaCyc:DSBC-MONOMER COG COG1651 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1651 DIP DIP-35818N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35818N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1021/bi00015a019 http://dx.doi.org/10.1021/bi00015a019 DOI 10.1021/bi9707739 http://dx.doi.org/10.1021/bi9707739 DOI 10.1038/73295 http://dx.doi.org/10.1038/73295 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1179557 http://dx.doi.org/10.1126/science.1179557 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M54884 http://www.ebi.ac.uk/ena/data/view/M54884 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 EchoBASE EB1063 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1063 EcoGene EG11070 http://www.ecogene.org/geneInfo.php?eg_id=EG11070 EnsemblBacteria AAC75931 http://www.ensemblgenomes.org/id/AAC75931 EnsemblBacteria AAC75931 http://www.ensemblgenomes.org/id/AAC75931 EnsemblBacteria BAE76958 http://www.ensemblgenomes.org/id/BAE76958 EnsemblBacteria BAE76958 http://www.ensemblgenomes.org/id/BAE76958 EnsemblBacteria BAE76958 http://www.ensemblgenomes.org/id/BAE76958 EnsemblBacteria b2893 http://www.ensemblgenomes.org/id/b2893 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0003756 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003756 GO_function GO:0015035 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015035 GO_process GO:0045454 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045454 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 Gene3D 3.10.450.70 http://www.cathdb.info/version/latest/superfamily/3.10.450.70 Gene3D 3.40.30.10 http://www.cathdb.info/version/latest/superfamily/3.40.30.10 GeneID 947363 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947363 HOGENOM HOG000222077 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000222077&db=HOGENOM6 InParanoid P0AEG6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEG6 IntAct P0AEG6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEG6* InterPro IPR009094 http://www.ebi.ac.uk/interpro/entry/IPR009094 InterPro IPR012336 http://www.ebi.ac.uk/interpro/entry/IPR012336 InterPro IPR013766 http://www.ebi.ac.uk/interpro/entry/IPR013766 InterPro IPR017937 http://www.ebi.ac.uk/interpro/entry/IPR017937 InterPro IPR018950 http://www.ebi.ac.uk/interpro/entry/IPR018950 InterPro IPR033954 http://www.ebi.ac.uk/interpro/entry/IPR033954 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW2861 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2861 KEGG_Gene eco:b2893 http://www.genome.jp/dbget-bin/www_bget?eco:b2893 KEGG_Orthology KO:K03981 http://www.genome.jp/dbget-bin/www_bget?KO:K03981 MINT MINT-1288669 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1288669 OMA VWCAKDP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VWCAKDP PDB 1EEJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1EEJ PDB 1G0T http://www.ebi.ac.uk/pdbe-srv/view/entry/1G0T PDB 1JZD http://www.ebi.ac.uk/pdbe-srv/view/entry/1JZD PDB 1JZO http://www.ebi.ac.uk/pdbe-srv/view/entry/1JZO PDB 1TJD http://www.ebi.ac.uk/pdbe-srv/view/entry/1TJD PDB 2IYJ http://www.ebi.ac.uk/pdbe-srv/view/entry/2IYJ PDBsum 1EEJ http://www.ebi.ac.uk/pdbsum/1EEJ PDBsum 1G0T http://www.ebi.ac.uk/pdbsum/1G0T PDBsum 1JZD http://www.ebi.ac.uk/pdbsum/1JZD PDBsum 1JZO http://www.ebi.ac.uk/pdbsum/1JZO PDBsum 1TJD http://www.ebi.ac.uk/pdbsum/1TJD PDBsum 2IYJ http://www.ebi.ac.uk/pdbsum/2IYJ PROSITE PS00194 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00194 PROSITE PS51352 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51352 PSORT swissprot:DSBC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DSBC_ECOLI PSORT-B swissprot:DSBC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DSBC_ECOLI PSORT2 swissprot:DSBC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DSBC_ECOLI Pfam PF10411 http://pfam.xfam.org/family/PF10411 Pfam PF13098 http://pfam.xfam.org/family/PF13098 Phobius swissprot:DSBC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DSBC_ECOLI PhylomeDB P0AEG6 http://phylomedb.org/?seqid=P0AEG6 ProteinModelPortal P0AEG6 http://www.proteinmodelportal.org/query/uniprot/P0AEG6 PubMed 10700276 http://www.ncbi.nlm.nih.gov/pubmed/10700276 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1987126 http://www.ncbi.nlm.nih.gov/pubmed/1987126 PubMed 19965429 http://www.ncbi.nlm.nih.gov/pubmed/19965429 PubMed 7536035 http://www.ncbi.nlm.nih.gov/pubmed/7536035 PubMed 8168497 http://www.ncbi.nlm.nih.gov/pubmed/8168497 PubMed 8168498 http://www.ncbi.nlm.nih.gov/pubmed/8168498 PubMed 9254601 http://www.ncbi.nlm.nih.gov/pubmed/9254601 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_417369 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417369 RefSeq WP_000715214 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000715214 SMR P0AEG6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEG6 STRING 511145.b2893 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2893&targetmode=cogs STRING COG1651 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1651&targetmode=cogs SUPFAM SSF52833 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52833 SUPFAM SSF54423 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54423 UniProtKB DSBC_ECOLI http://www.uniprot.org/uniprot/DSBC_ECOLI UniProtKB-AC P0AEG6 http://www.uniprot.org/uniprot/P0AEG6 charge swissprot:DSBC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DSBC_ECOLI eggNOG COG1651 http://eggnogapi.embl.de/nog_data/html/tree/COG1651 eggNOG ENOG4105T95 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105T95 epestfind swissprot:DSBC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DSBC_ECOLI garnier swissprot:DSBC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DSBC_ECOLI helixturnhelix swissprot:DSBC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DSBC_ECOLI hmoment swissprot:DSBC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DSBC_ECOLI iep swissprot:DSBC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DSBC_ECOLI inforesidue swissprot:DSBC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DSBC_ECOLI octanol swissprot:DSBC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DSBC_ECOLI pepcoil swissprot:DSBC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DSBC_ECOLI pepdigest swissprot:DSBC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DSBC_ECOLI pepinfo swissprot:DSBC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DSBC_ECOLI pepnet swissprot:DSBC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DSBC_ECOLI pepstats swissprot:DSBC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DSBC_ECOLI pepwheel swissprot:DSBC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DSBC_ECOLI pepwindow swissprot:DSBC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DSBC_ECOLI sigcleave swissprot:DSBC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DSBC_ECOLI ## Database ID URL or Descriptions # BioGrid 4259806 11 # EcoGene EG13599 yahO # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GOslim_component GO:0005575 cellular_component # Gene3D 3.30.1660.10 -; 1. # IntAct P75694 5 # InterPro IPR010854 DUF1471 # InterPro IPR025543 Dodecin-like # Organism YAHO_ECOLI Escherichia coli (strain K12) # PATRIC 32115787 VBIEscCol129921_0335 # PIR A64760 A64760 # Pfam PF07338 DUF1471 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAHO_ECOLI Uncharacterized protein YahO # RefSeq NP_414863 NC_000913.3 # RefSeq WP_000691956 NZ_LN832404.1 # SIMILARITY Belongs to the BhsA/McbA family. {ECO 0000305}. # SUBCELLULAR LOCATION YAHO_ECOLI Periplasm {ECO 0000305}. # SUPFAM SSF159871 SSF159871 # eggNOG ENOG4105TDT Bacteria # eggNOG ENOG4111X9Y LUCA BLAST swissprot:YAHO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAHO_ECOLI BioCyc ECOL316407:JW0321-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0321-MONOMER BioCyc EcoCyc:G6194-MONOMER http://biocyc.org/getid?id=EcoCyc:G6194-MONOMER DIP DIP-11267N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11267N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3368 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3368 EcoGene EG13599 http://www.ecogene.org/geneInfo.php?eg_id=EG13599 EnsemblBacteria AAC73432 http://www.ensemblgenomes.org/id/AAC73432 EnsemblBacteria AAC73432 http://www.ensemblgenomes.org/id/AAC73432 EnsemblBacteria BAE76112 http://www.ensemblgenomes.org/id/BAE76112 EnsemblBacteria BAE76112 http://www.ensemblgenomes.org/id/BAE76112 EnsemblBacteria BAE76112 http://www.ensemblgenomes.org/id/BAE76112 EnsemblBacteria b0329 http://www.ensemblgenomes.org/id/b0329 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 Gene3D 3.30.1660.10 http://www.cathdb.info/version/latest/superfamily/3.30.1660.10 GeneID 944985 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944985 HOGENOM HOG000117400 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117400&db=HOGENOM6 IntAct P75694 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75694* InterPro IPR010854 http://www.ebi.ac.uk/interpro/entry/IPR010854 InterPro IPR025543 http://www.ebi.ac.uk/interpro/entry/IPR025543 KEGG_Gene ecj:JW0321 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0321 KEGG_Gene eco:b0329 http://www.genome.jp/dbget-bin/www_bget?eco:b0329 MINT MINT-1275385 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1275385 OMA MIAMASF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MIAMASF PSORT swissprot:YAHO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAHO_ECOLI PSORT-B swissprot:YAHO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAHO_ECOLI PSORT2 swissprot:YAHO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAHO_ECOLI Pfam PF07338 http://pfam.xfam.org/family/PF07338 Phobius swissprot:YAHO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAHO_ECOLI ProteinModelPortal P75694 http://www.proteinmodelportal.org/query/uniprot/P75694 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414863 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414863 RefSeq WP_000691956 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000691956 SMR P75694 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75694 STRING 511145.b0329 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0329&targetmode=cogs SUPFAM SSF159871 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF159871 UniProtKB YAHO_ECOLI http://www.uniprot.org/uniprot/YAHO_ECOLI UniProtKB-AC P75694 http://www.uniprot.org/uniprot/P75694 charge swissprot:YAHO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAHO_ECOLI eggNOG ENOG4105TDT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105TDT eggNOG ENOG4111X9Y http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111X9Y epestfind swissprot:YAHO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAHO_ECOLI garnier swissprot:YAHO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAHO_ECOLI helixturnhelix swissprot:YAHO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAHO_ECOLI hmoment swissprot:YAHO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAHO_ECOLI iep swissprot:YAHO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAHO_ECOLI inforesidue swissprot:YAHO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAHO_ECOLI octanol swissprot:YAHO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAHO_ECOLI pepcoil swissprot:YAHO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAHO_ECOLI pepdigest swissprot:YAHO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAHO_ECOLI pepinfo swissprot:YAHO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAHO_ECOLI pepnet swissprot:YAHO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAHO_ECOLI pepstats swissprot:YAHO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAHO_ECOLI pepwheel swissprot:YAHO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAHO_ECOLI pepwindow swissprot:YAHO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAHO_ECOLI sigcleave swissprot:YAHO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAHO_ECOLI ## Database ID URL or Descriptions # EcoGene EG40012 insL2 # FUNCTION INSL2_ECOLI Involved in the transposition of the insertion sequence IS186. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 3.90.350.10 -; 1. # InterPro IPR002559 Transposase_11 # InterPro IPR012337 RNaseH-like_dom # InterPro IPR014736 Transposase_Tn5-like_core # Organism INSL2_ECOLI Escherichia coli (strain K12) # PIR G65013 QQEC47 # Pfam PF01609 DDE_Tnp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSL2_ECOLI Putative transposase InsL for insertion sequence element IS186B # RefSeq NP_414557 NC_000913.3 # RefSeq NP_415114 NC_000913.3 # RefSeq NP_416895 NC_000913.3 # RefSeq WP_001300563 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40781.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the transposase 11 family. {ECO 0000305}. # SUPFAM SSF53098 SSF53098 # eggNOG COG3385 LUCA # eggNOG ENOG4108SER Bacteria BLAST swissprot:INSL2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSL2_ECOLI BioCyc EcoCyc:MONOMER0-4232 http://biocyc.org/getid?id=EcoCyc:MONOMER0-4232 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB4754 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4754 EcoGene EG40012 http://www.ecogene.org/geneInfo.php?eg_id=EG40012 EnsemblBacteria AAC73683 http://www.ensemblgenomes.org/id/AAC73683 EnsemblBacteria AAC73683 http://www.ensemblgenomes.org/id/AAC73683 EnsemblBacteria BAA35223 http://www.ensemblgenomes.org/id/BAA35223 EnsemblBacteria BAA35223 http://www.ensemblgenomes.org/id/BAA35223 EnsemblBacteria BAA35223 http://www.ensemblgenomes.org/id/BAA35223 EnsemblBacteria b0582 http://www.ensemblgenomes.org/id/b0582 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 3.90.350.10 http://www.cathdb.info/version/latest/superfamily/3.90.350.10 GeneID 944754 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944754 GeneID 945200 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945200 GeneID 946896 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946896 InParanoid P0CF92 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CF92 InterPro IPR002559 http://www.ebi.ac.uk/interpro/entry/IPR002559 InterPro IPR012337 http://www.ebi.ac.uk/interpro/entry/IPR012337 InterPro IPR014736 http://www.ebi.ac.uk/interpro/entry/IPR014736 KEGG_Gene ecj:JW0572 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0572 KEGG_Gene eco:b0016 http://www.genome.jp/dbget-bin/www_bget?eco:b0016 KEGG_Gene eco:b0582 http://www.genome.jp/dbget-bin/www_bget?eco:b0582 KEGG_Gene eco:b2394 http://www.genome.jp/dbget-bin/www_bget?eco:b2394 PSORT swissprot:INSL2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSL2_ECOLI PSORT-B swissprot:INSL2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSL2_ECOLI PSORT2 swissprot:INSL2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSL2_ECOLI Pfam PF01609 http://pfam.xfam.org/family/PF01609 Phobius swissprot:INSL2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSL2_ECOLI ProteinModelPortal P0CF92 http://www.proteinmodelportal.org/query/uniprot/P0CF92 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414557 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414557 RefSeq NP_415114 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415114 RefSeq NP_416895 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416895 RefSeq WP_001300563 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300563 STRING 511145.b2394 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2394&targetmode=cogs SUPFAM SSF53098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098 UniProtKB INSL2_ECOLI http://www.uniprot.org/uniprot/INSL2_ECOLI UniProtKB-AC P0CF92 http://www.uniprot.org/uniprot/P0CF92 charge swissprot:INSL2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSL2_ECOLI eggNOG COG3385 http://eggnogapi.embl.de/nog_data/html/tree/COG3385 eggNOG ENOG4108SER http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108SER epestfind swissprot:INSL2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSL2_ECOLI garnier swissprot:INSL2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSL2_ECOLI helixturnhelix swissprot:INSL2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSL2_ECOLI hmoment swissprot:INSL2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSL2_ECOLI iep swissprot:INSL2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSL2_ECOLI inforesidue swissprot:INSL2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSL2_ECOLI octanol swissprot:INSL2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSL2_ECOLI pepcoil swissprot:INSL2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSL2_ECOLI pepdigest swissprot:INSL2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSL2_ECOLI pepinfo swissprot:INSL2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSL2_ECOLI pepnet swissprot:INSL2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSL2_ECOLI pepstats swissprot:INSL2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSL2_ECOLI pepwheel swissprot:INSL2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSL2_ECOLI pepwindow swissprot:INSL2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSL2_ECOLI sigcleave swissprot:INSL2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSL2_ECOLI ## Database ID URL or Descriptions # BioGrid 4262033 8 # CATALYTIC ACTIVITY ADRA_ECOLI 2 GTP = 2 diphosphate + cyclic di-3',5'- guanylate. # CDD cd01949 GGDEF # COFACTOR ADRA_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250}; Note=Binds 1 Mg(2+) ion per monomer. {ECO 0000250}; # EcoGene EG11257 adrA # FUNCTION ADRA_ECOLI A probable diguanylate cyclase. The last member of a cascade of expressed proteins, its expression requires YdaM. AdrA production induces biosynthesis of cellulose in some E.coli isolates, but not in K12 strains. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria. {ECO 0000269|PubMed 19707751}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005525 GTP binding; IEA:UniProtKB-KW. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0052621 diguanylate cyclase activity; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0043167 ion binding # INDUCTION ADRA_ECOLI Expressed at 28 degrees Celsius in late stationary phase, more highly expressed on plates than in liquid medium. Expression is RpoS-, CsgD- and YdaM-dependent. {ECO 0000269|PubMed 17010156, ECO 0000269|PubMed 19332833}. # InterPro IPR000160 GGDEF_dom # InterPro IPR007894 MASE2 # InterPro IPR029787 Nucleotide_cyclase # Organism ADRA_ECOLI Escherichia coli (strain K12) # PATHWAY ADRA_ECOLI Purine metabolism; 3',5'-cyclic di-GMP biosynthesis. # PATRIC 32115911 VBIEscCol129921_0397 # PIR A64767 A64767 # PROSITE PS50887 GGDEF # Pfam PF00990 GGDEF # Pfam PF05230 MASE2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ADRA_ECOLI Probable diguanylate cyclase AdrA # RefSeq NP_414919 NC_000913.3 # RefSeq WP_000484048 NZ_LN832404.1 # SIMILARITY Contains 1 GGDEF domain. {ECO:0000255|PROSITE- ProRule PRU00095}. # SMART SM00267 GGDEF # SUBCELLULAR LOCATION ADRA_ECOLI Cell inner membrane {ECO 0000305}; Multi- pass membrane protein {ECO 0000305}. # SUBUNIT Homodimer. {ECO 0000250}. # SUPFAM SSF55073 SSF55073 # TCDB 9.B.34.1 the kinase/phosphatase/cyclic-gmp synthase/cyclic di-gmp hydrolase (kpsh) family # TIGRFAMs TIGR00254 GGDEF # eggNOG ENOG4105BZU Bacteria # eggNOG ENOG410XNMH LUCA BLAST swissprot:ADRA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ADRA_ECOLI BioCyc ECOL316407:JW0376-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0376-MONOMER BioCyc EcoCyc:EG11257-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11257-MONOMER BioCyc MetaCyc:EG11257-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11257-MONOMER DOI 10.1007/s00253-009-2199-x http://dx.doi.org/10.1007/s00253-009-2199-x DOI 10.1016/0378-1119(86)90050-8 http://dx.doi.org/10.1016/0378-1119(86)90050-8 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2001.02337.x http://dx.doi.org/10.1046/j.1365-2958.2001.02337.x DOI 10.1099/mic.0.024257-0 http://dx.doi.org/10.1099/mic.0.024257-0 DOI 10.1111/j.1365-2958.2006.05440.x http://dx.doi.org/10.1111/j.1365-2958.2006.05440.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.188.6.2027-2037.2006 http://dx.doi.org/10.1128/JB.188.6.2027-2037.2006 EC_number EC:2.7.7.65 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.65 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M13345 http://www.ebi.ac.uk/ena/data/view/M13345 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 ENZYME 2.7.7.65 http://enzyme.expasy.org/EC/2.7.7.65 EchoBASE EB1237 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1237 EcoGene EG11257 http://www.ecogene.org/geneInfo.php?eg_id=EG11257 EnsemblBacteria AAC73488 http://www.ensemblgenomes.org/id/AAC73488 EnsemblBacteria AAC73488 http://www.ensemblgenomes.org/id/AAC73488 EnsemblBacteria BAE76166 http://www.ensemblgenomes.org/id/BAE76166 EnsemblBacteria BAE76166 http://www.ensemblgenomes.org/id/BAE76166 EnsemblBacteria BAE76166 http://www.ensemblgenomes.org/id/BAE76166 EnsemblBacteria b0385 http://www.ensemblgenomes.org/id/b0385 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0052621 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052621 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GeneID 945037 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945037 HOGENOM HOG000117511 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117511&db=HOGENOM6 InParanoid P0AAP1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAP1 IntEnz 2.7.7.65 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.65 InterPro IPR000160 http://www.ebi.ac.uk/interpro/entry/IPR000160 InterPro IPR007894 http://www.ebi.ac.uk/interpro/entry/IPR007894 InterPro IPR029787 http://www.ebi.ac.uk/interpro/entry/IPR029787 KEGG_Gene ecj:JW0376 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0376 KEGG_Gene eco:b0385 http://www.genome.jp/dbget-bin/www_bget?eco:b0385 OMA HGAWKDL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HGAWKDL PROSITE PS50887 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50887 PSORT swissprot:ADRA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ADRA_ECOLI PSORT-B swissprot:ADRA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ADRA_ECOLI PSORT2 swissprot:ADRA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ADRA_ECOLI Pfam PF00990 http://pfam.xfam.org/family/PF00990 Pfam PF05230 http://pfam.xfam.org/family/PF05230 Phobius swissprot:ADRA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ADRA_ECOLI PhylomeDB P0AAP1 http://phylomedb.org/?seqid=P0AAP1 ProteinModelPortal P0AAP1 http://www.proteinmodelportal.org/query/uniprot/P0AAP1 PubMed 11260463 http://www.ncbi.nlm.nih.gov/pubmed/11260463 PubMed 16513732 http://www.ncbi.nlm.nih.gov/pubmed/16513732 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17010156 http://www.ncbi.nlm.nih.gov/pubmed/17010156 PubMed 19332833 http://www.ncbi.nlm.nih.gov/pubmed/19332833 PubMed 19707751 http://www.ncbi.nlm.nih.gov/pubmed/19707751 PubMed 3533724 http://www.ncbi.nlm.nih.gov/pubmed/3533724 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414919 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414919 RefSeq WP_000484048 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000484048 SMART SM00267 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00267 SMR P0AAP1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAP1 STRING 511145.b0385 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0385&targetmode=cogs SUPFAM SSF55073 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55073 TCDB 9.B.34.1 http://www.tcdb.org/search/result.php?tc=9.B.34.1 TIGRFAMs TIGR00254 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00254 UniProtKB ADRA_ECOLI http://www.uniprot.org/uniprot/ADRA_ECOLI UniProtKB-AC P0AAP1 http://www.uniprot.org/uniprot/P0AAP1 charge swissprot:ADRA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ADRA_ECOLI eggNOG ENOG4105BZU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZU eggNOG ENOG410XNMH http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNMH epestfind swissprot:ADRA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ADRA_ECOLI garnier swissprot:ADRA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ADRA_ECOLI helixturnhelix swissprot:ADRA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ADRA_ECOLI hmoment swissprot:ADRA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ADRA_ECOLI iep swissprot:ADRA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ADRA_ECOLI inforesidue swissprot:ADRA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ADRA_ECOLI octanol swissprot:ADRA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ADRA_ECOLI pepcoil swissprot:ADRA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ADRA_ECOLI pepdigest swissprot:ADRA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ADRA_ECOLI pepinfo swissprot:ADRA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ADRA_ECOLI pepnet swissprot:ADRA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ADRA_ECOLI pepstats swissprot:ADRA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ADRA_ECOLI pepwheel swissprot:ADRA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ADRA_ECOLI pepwindow swissprot:ADRA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ADRA_ECOLI sigcleave swissprot:ADRA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ADRA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259183 8 # EcoGene EG14157 mntH # FUNCTION MNTH_ECOLI H(+)-stimulated, divalent metal cation uptake system. Involved in manganese and iron uptake. Can also transport cadmium, cobalt, zinc and to a lesser extent nickel and copper. Involved in response to reactive oxygen. {ECO 0000255|HAMAP-Rule MF_00221, ECO 0000269|PubMed 10712688, ECO 0000269|PubMed 10844693}. # GO_component GO:0005886 plasma membrane; IDA:EcoliWiki. # GO_component GO:0016021 integral component of membrane; IMP:EcoliWiki. # GO_function GO:0005384 manganese ion transmembrane transporter activity; IMP:EcoliWiki. # GO_function GO:0015078 hydrogen ion transmembrane transporter activity; IMP:EcoliWiki. # GO_function GO:0015086 cadmium ion transmembrane transporter activity; IMP:EcoliWiki. # GO_function GO:0015292 uniporter activity; IMP:EcoliWiki. # GO_function GO:0015293 symporter activity; IDA:EcoliWiki. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006824 cobalt ion transport; IMP:EcoliWiki. # GO_process GO:0006826 iron ion transport; IMP:EcoliWiki. # GO_process GO:0006828 manganese ion transport; IMP:EcoCyc. # GO_process GO:0015684 ferrous iron transport; IMP:EcoliWiki. # GO_process GO:0015691 cadmium ion transport; IDA:EcoliWiki. # GO_process GO:0030001 metal ion transport; IMP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # HAMAP MF_00221 NRAMP # InterPro IPR001046 NRAMP_fam # KEGG_Brite ko02000 Transporters # Organism MNTH_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11706 PTHR11706 # PATRIC 32120161 VBIEscCol129921_2489 # PIR E65013 E65013 # PRINTS PR00447 NATRESASSCMP # Pfam PF01566 Nramp # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Divalent metal cation transporter MntH {ECO:0000255|HAMAP-Rule MF_00221} # RefSeq NP_416893 NC_000913.3 # RefSeq WP_000186369 NZ_LN832404.1 # SIMILARITY Belongs to the NRAMP family. {ECO:0000255|HAMAP- Rule MF_00221}. # SUBCELLULAR LOCATION MNTH_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_00221, ECO 0000269|PubMed 14607838}; Multi-pass membrane protein {ECO 0000255|HAMAP-Rule MF_00221, ECO 0000269|PubMed 14607838}. # TCDB 2.A.55.3 the metal ion (mn(2+)-iron) transporter (nramp) family # TIGRFAMs TIGR01197 nramp # eggNOG COG1914 LUCA # eggNOG ENOG4105C56 Bacteria BLAST swissprot:MNTH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MNTH_ECOLI BioCyc ECOL316407:JW2388-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2388-MONOMER BioCyc EcoCyc:YFEP-MONOMER http://biocyc.org/getid?id=EcoCyc:YFEP-MONOMER BioCyc MetaCyc:YFEP-MONOMER http://biocyc.org/getid?id=MetaCyc:YFEP-MONOMER COG COG1914 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1914 DIP DIP-48004N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48004N DOI 10.1007/s00232-004-0711-x http://dx.doi.org/10.1007/s00232-004-0711-x DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2000.01774.x http://dx.doi.org/10.1046/j.1365-2958.2000.01774.x DOI 10.1046/j.1365-2958.2000.01922.x http://dx.doi.org/10.1046/j.1365-2958.2000.01922.x DOI 10.1074/jbc.M309913200 http://dx.doi.org/10.1074/jbc.M309913200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AF161318 http://www.ebi.ac.uk/ena/data/view/AF161318 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3909 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3909 EcoGene EG14157 http://www.ecogene.org/geneInfo.php?eg_id=EG14157 EnsemblBacteria AAC75451 http://www.ensemblgenomes.org/id/AAC75451 EnsemblBacteria AAC75451 http://www.ensemblgenomes.org/id/AAC75451 EnsemblBacteria BAA16262 http://www.ensemblgenomes.org/id/BAA16262 EnsemblBacteria BAA16262 http://www.ensemblgenomes.org/id/BAA16262 EnsemblBacteria BAA16262 http://www.ensemblgenomes.org/id/BAA16262 EnsemblBacteria b2392 http://www.ensemblgenomes.org/id/b2392 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005384 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005384 GO_function GO:0015078 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015078 GO_function GO:0015086 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015086 GO_function GO:0015292 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015292 GO_function GO:0015293 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006824 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006824 GO_process GO:0006826 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006826 GO_process GO:0006828 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006828 GO_process GO:0015684 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015684 GO_process GO:0015691 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015691 GO_process GO:0030001 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030001 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 946899 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946899 HAMAP MF_00221 http://hamap.expasy.org/unirule/MF_00221 HOGENOM HOG000152205 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000152205&db=HOGENOM6 InParanoid P0A769 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A769 IntAct P0A769 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A769* InterPro IPR001046 http://www.ebi.ac.uk/interpro/entry/IPR001046 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2388 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2388 KEGG_Gene eco:b2392 http://www.genome.jp/dbget-bin/www_bget?eco:b2392 KEGG_Orthology KO:K03322 http://www.genome.jp/dbget-bin/www_bget?KO:K03322 OMA ERYSATK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ERYSATK PANTHER PTHR11706 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11706 PRINTS PR00447 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00447 PSORT swissprot:MNTH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MNTH_ECOLI PSORT-B swissprot:MNTH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MNTH_ECOLI PSORT2 swissprot:MNTH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MNTH_ECOLI Pfam PF01566 http://pfam.xfam.org/family/PF01566 Phobius swissprot:MNTH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MNTH_ECOLI PhylomeDB P0A769 http://phylomedb.org/?seqid=P0A769 ProteinModelPortal P0A769 http://www.proteinmodelportal.org/query/uniprot/P0A769 PubMed 10712688 http://www.ncbi.nlm.nih.gov/pubmed/10712688 PubMed 10844693 http://www.ncbi.nlm.nih.gov/pubmed/10844693 PubMed 14607838 http://www.ncbi.nlm.nih.gov/pubmed/14607838 PubMed 15630547 http://www.ncbi.nlm.nih.gov/pubmed/15630547 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416893 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416893 RefSeq WP_000186369 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000186369 STRING 511145.b2392 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2392&targetmode=cogs STRING COG1914 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1914&targetmode=cogs TCDB 2.A.55.3 http://www.tcdb.org/search/result.php?tc=2.A.55.3 TIGRFAMs TIGR01197 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01197 UniProtKB MNTH_ECOLI http://www.uniprot.org/uniprot/MNTH_ECOLI UniProtKB-AC P0A769 http://www.uniprot.org/uniprot/P0A769 charge swissprot:MNTH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MNTH_ECOLI eggNOG COG1914 http://eggnogapi.embl.de/nog_data/html/tree/COG1914 eggNOG ENOG4105C56 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C56 epestfind swissprot:MNTH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MNTH_ECOLI garnier swissprot:MNTH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MNTH_ECOLI helixturnhelix swissprot:MNTH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MNTH_ECOLI hmoment swissprot:MNTH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MNTH_ECOLI iep swissprot:MNTH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MNTH_ECOLI inforesidue swissprot:MNTH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MNTH_ECOLI octanol swissprot:MNTH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MNTH_ECOLI pepcoil swissprot:MNTH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MNTH_ECOLI pepdigest swissprot:MNTH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MNTH_ECOLI pepinfo swissprot:MNTH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MNTH_ECOLI pepnet swissprot:MNTH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MNTH_ECOLI pepstats swissprot:MNTH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MNTH_ECOLI pepwheel swissprot:MNTH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MNTH_ECOLI pepwindow swissprot:MNTH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MNTH_ECOLI sigcleave swissprot:MNTH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MNTH_ECOLI ## Database ID URL or Descriptions # BioGrid 4261029 21 # EcoGene EG10890 rpmF # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0022625 cytosolic large ribosomal subunit; IDA:EcoCyc. # GO_function GO:0003735 structural constituent of ribosome; IEA:InterPro. # GO_process GO:0006412 translation; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_process GO:0006412 translation # HAMAP MF_00340 Ribosomal_L32 # INTERACTION RL32_ECOLI P0A7M2 rpmB; NbExp=2; IntAct=EBI-1112732, EBI-543024; # IntAct P0A7N4 8 # InterPro IPR002677 Ribosomal_L32p # InterPro IPR011332 Ribosomal_zn-bd # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=6315.1; Method=MALDI; Range=2-57; Evidence={ECO:0000269|PubMed 10094780}; # Organism RL32_ECOLI Escherichia coli (strain K12) # PATRIC 32117419 VBIEscCol129921_1132 # PDB 2J28 EM; 8.00 A; 0=2-57 # PDB 2RDO EM; 9.10 A; 0=2-57 # PDB 3BBX EM; 10.00 A; 0=2-57 # PDB 3J5L EM; 6.60 A; 0=2-57 # PDB 3J7Z EM; 3.90 A; 0=1-57 # PDB 3J8G EM; 5.00 A; 3=1-57 # PDB 3J9Y EM; 3.90 A; 0=1-57 # PDB 3J9Z EM; 3.60 A; L1=2-57 # PDB 3JA1 EM; 3.60 A; L3=2-57 # PDB 3JBU EM; 3.64 A; 3=1-57 # PDB 3JBV EM; 3.32 A; 3=1-57 # PDB 3JCD EM; 3.70 A; 0=1-57 # PDB 3JCE EM; 3.20 A; 0=1-57 # PDB 3JCJ EM; 3.70 A; Z=1-57 # PDB 3JCN EM; 4.60 A; 0=1-57 # PDB 4CSU EM; 5.50 A; 3=2-57 # PDB 4U1U X-ray; 2.95 A; B0/D0=2-57 # PDB 4U1V X-ray; 3.00 A; B0/D0=2-57 # PDB 4U20 X-ray; 2.90 A; B0/D0=2-57 # PDB 4U24 X-ray; 2.90 A; B0/D0=2-57 # PDB 4U25 X-ray; 2.90 A; B0/D0=2-57 # PDB 4U26 X-ray; 2.80 A; B0/D0=2-57 # PDB 4U27 X-ray; 2.80 A; B0/D0=2-57 # PDB 4UY8 EM; 3.80 A; 0=2-57 # PDB 4V47 EM; 12.30 A; AZ=2-57 # PDB 4V48 EM; 11.50 A; AZ=2-57 # PDB 4V4H X-ray; 3.46 A; B0/D0=1-57 # PDB 4V4Q X-ray; 3.46 A; B0/D0=2-57 # PDB 4V4V EM; 15.00 A; BZ=28-56 # PDB 4V4W EM; 15.00 A; BZ=28-56 # PDB 4V50 X-ray; 3.22 A; B0/D0=2-57 # PDB 4V52 X-ray; 3.21 A; B0/D0=2-57 # PDB 4V53 X-ray; 3.54 A; B0/D0=2-57 # PDB 4V54 X-ray; 3.30 A; B0/D0=2-57 # PDB 4V55 X-ray; 4.00 A; B0/D0=2-57 # PDB 4V56 X-ray; 3.93 A; B0/D0=2-57 # PDB 4V57 X-ray; 3.50 A; B0/D0=2-57 # PDB 4V5B X-ray; 3.74 A; A0/C0=2-57 # PDB 4V5H EM; 5.80 A; B3=2-57 # PDB 4V5Y X-ray; 4.45 A; B0/D0=2-57 # PDB 4V64 X-ray; 3.50 A; B0/D0=2-57 # PDB 4V65 EM; 9.00 A; BT=1-57 # PDB 4V66 EM; 9.00 A; BT=1-57 # PDB 4V69 EM; 6.70 A; B0=2-57 # PDB 4V6C X-ray; 3.19 A; B0/D0=1-57 # PDB 4V6D X-ray; 3.81 A; B0/D0=1-57 # PDB 4V6E X-ray; 3.71 A; B0/D0=1-57 # PDB 4V6K EM; 8.25 A; Ac=1-57 # PDB 4V6L EM; 13.20 A; Bc=1-57 # PDB 4V6M EM; 7.10 A; B0=2-57 # PDB 4V6N EM; 12.10 A; A3=2-57 # PDB 4V6O EM; 14.70 A; B3=2-57 # PDB 4V6P EM; 13.50 A; B3=2-57 # PDB 4V6Q EM; 11.50 A; B3=2-57 # PDB 4V6R EM; 11.50 A; B3=2-57 # PDB 4V6S EM; 13.10 A; A3=2-57 # PDB 4V6T EM; 8.30 A; B0=2-57 # PDB 4V6V EM; 9.80 A; B5=2-57 # PDB 4V6Y EM; 12.00 A; B0=1-57 # PDB 4V6Z EM; 12.00 A; B0=1-57 # PDB 4V70 EM; 17.00 A; B0=1-57 # PDB 4V71 EM; 20.00 A; B0=1-57 # PDB 4V72 EM; 13.00 A; B0=1-57 # PDB 4V73 EM; 15.00 A; B0=1-57 # PDB 4V74 EM; 17.00 A; B0=1-57 # PDB 4V75 EM; 12.00 A; B0=1-57 # PDB 4V76 EM; 17.00 A; B0=1-57 # PDB 4V77 EM; 17.00 A; B0=1-57 # PDB 4V78 EM; 20.00 A; B0=1-57 # PDB 4V79 EM; 15.00 A; B0=1-57 # PDB 4V7A EM; 9.00 A; B0=1-57 # PDB 4V7B EM; 6.80 A; B0=1-57 # PDB 4V7C EM; 7.60 A; B3=2-57 # PDB 4V7D EM; 7.60 A; A4=2-57 # PDB 4V7I EM; 9.60 A; A0=1-57 # PDB 4V7S X-ray; 3.25 A; B0/D0=2-57 # PDB 4V7T X-ray; 3.19 A; B0/D0=2-57 # PDB 4V7U X-ray; 3.10 A; B0/D0=2-57 # PDB 4V7V X-ray; 3.29 A; B0/D0=2-57 # PDB 4V85 X-ray; 3.20 A; 4=1-57 # PDB 4V89 X-ray; 3.70 A; B4=1-57 # PDB 4V9C X-ray; 3.30 A; B0/D0=1-57 # PDB 4V9D X-ray; 3.00 A; C0/D0=2-57 # PDB 4V9O X-ray; 2.90 A; A0/C0/E0/G0=1-57 # PDB 4V9P X-ray; 2.90 A; A0/C0/E0/G0=1-57 # PDB 4WF1 X-ray; 3.09 A; B0/D0=2-57 # PDB 4WOI X-ray; 3.00 A; B0/C0=1-57 # PDB 4WWW X-ray; 3.10 A; R0/Y0=2-57 # PDB 4YBB X-ray; 2.10 A; C1/D1=2-57 # PDB 5ADY EM; 4.50 A; 0=1-57 # PDB 5AFI EM; 2.90 A; 0=1-57 # PDB 5AKA EM; 5.70 A; 0=2-57 # PDB 5GAD EM; 3.70 A; b=1-57 # PDB 5GAE EM; 3.33 A; b=1-57 # PDB 5GAF EM; 4.30 A; b=2-57 # PDB 5GAG EM; 3.80 A; b=1-57 # PDB 5GAH EM; 3.80 A; b=1-57 # PDB 5IQR EM; 3.00 A; b=1-57 # PDB 5IT8 X-ray; 3.12 A; C1/D1=2-57 # PDB 5J5B X-ray; 2.80 A; C1/D1=2-57 # PDB 5J7L X-ray; 3.00 A; C1/D1=2-57 # PDB 5J88 X-ray; 3.32 A; C1/D1=2-57 # PDB 5J8A X-ray; 3.10 A; C1/D1=2-57 # PDB 5J91 X-ray; 2.96 A; C1/D1=2-57 # PDB 5JC9 X-ray; 3.03 A; C1/D1=2-57 # PDB 5JTE EM; 3.60 A; B0=1-57 # PDB 5JU8 EM; 3.60 A; B0=1-57 # PDB 5KCR EM; 3.60 A; 15=1-57 # PDB 5KCS EM; 3.90 A; 15=1-57 # PDB 5KPS EM; 3.90 A; 2=1-57 # PDB 5KPV EM; 4.10 A; 1=1-57 # PDB 5KPW EM; 3.90 A; 1=1-57 # PDB 5KPX EM; 3.90 A; 1=1-57 # PDB 5L3P EM; 3.70 A; 5=1-57 # PIR JV0048 R5EC32 # Pfam PF01783 Ribosomal_L32p # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RL32_ECOLI 50S ribosomal protein L32 # RefSeq NP_415607 NC_000913.3 # RefSeq WP_000290727 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein L32P family. {ECO 0000305}. # SUBUNIT Part of the 50S ribosomal subunit. Contacts L17 (PubMed:2665813). {ECO 0000269|PubMed:2665813}. # SUPFAM SSF57829 SSF57829 # TIGRFAMs TIGR01031 rpmF_bact # eggNOG COG0333 LUCA BLAST swissprot:RL32_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RL32_ECOLI BioCyc ECOL316407:JW1075-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1075-MONOMER BioCyc EcoCyc:EG10890-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10890-MONOMER BioCyc MetaCyc:EG10890-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10890-MONOMER COG COG0333 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0333 DIP DIP-35782N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35782N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1016/S0092-8674(03)00427-6 http://dx.doi.org/10.1016/S0092-8674(03)00427-6 DOI 10.1016/j.celrep.2014.09.011 http://dx.doi.org/10.1016/j.celrep.2014.09.011 DOI 10.1021/bi00435a071 http://dx.doi.org/10.1021/bi00435a071 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pbio.1001866 http://dx.doi.org/10.1371/journal.pbio.1001866 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M29698 http://www.ebi.ac.uk/ena/data/view/M29698 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0883 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0883 EcoGene EG10890 http://www.ecogene.org/geneInfo.php?eg_id=EG10890 EnsemblBacteria AAC74173 http://www.ensemblgenomes.org/id/AAC74173 EnsemblBacteria AAC74173 http://www.ensemblgenomes.org/id/AAC74173 EnsemblBacteria BAA35897 http://www.ensemblgenomes.org/id/BAA35897 EnsemblBacteria BAA35897 http://www.ensemblgenomes.org/id/BAA35897 EnsemblBacteria BAA35897 http://www.ensemblgenomes.org/id/BAA35897 EnsemblBacteria b1089 http://www.ensemblgenomes.org/id/b1089 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0022625 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022625 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GeneID 945657 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945657 HAMAP MF_00340 http://hamap.expasy.org/unirule/MF_00340 HOGENOM HOG000040269 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000040269&db=HOGENOM6 InParanoid P0A7N4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7N4 IntAct P0A7N4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7N4* InterPro IPR002677 http://www.ebi.ac.uk/interpro/entry/IPR002677 InterPro IPR011332 http://www.ebi.ac.uk/interpro/entry/IPR011332 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW1075 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1075 KEGG_Gene eco:b1089 http://www.genome.jp/dbget-bin/www_bget?eco:b1089 KEGG_Orthology KO:K02911 http://www.genome.jp/dbget-bin/www_bget?KO:K02911 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 OMA HRAHDFL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HRAHDFL PDB 2J28 http://www.ebi.ac.uk/pdbe-srv/view/entry/2J28 PDB 2RDO http://www.ebi.ac.uk/pdbe-srv/view/entry/2RDO PDB 3BBX http://www.ebi.ac.uk/pdbe-srv/view/entry/3BBX PDB 3J5L http://www.ebi.ac.uk/pdbe-srv/view/entry/3J5L PDB 3J7Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J7Z PDB 3J8G http://www.ebi.ac.uk/pdbe-srv/view/entry/3J8G PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 4CSU http://www.ebi.ac.uk/pdbe-srv/view/entry/4CSU PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4UY8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4UY8 PDB 4V47 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V47 PDB 4V48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V48 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5ADY http://www.ebi.ac.uk/pdbe-srv/view/entry/5ADY PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5AKA http://www.ebi.ac.uk/pdbe-srv/view/entry/5AKA PDB 5GAD http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAD PDB 5GAE http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAE PDB 5GAF http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAF PDB 5GAG http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAG PDB 5GAH http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAH PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 2J28 http://www.ebi.ac.uk/pdbsum/2J28 PDBsum 2RDO http://www.ebi.ac.uk/pdbsum/2RDO PDBsum 3BBX http://www.ebi.ac.uk/pdbsum/3BBX PDBsum 3J5L http://www.ebi.ac.uk/pdbsum/3J5L PDBsum 3J7Z http://www.ebi.ac.uk/pdbsum/3J7Z PDBsum 3J8G http://www.ebi.ac.uk/pdbsum/3J8G PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 4CSU http://www.ebi.ac.uk/pdbsum/4CSU PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4UY8 http://www.ebi.ac.uk/pdbsum/4UY8 PDBsum 4V47 http://www.ebi.ac.uk/pdbsum/4V47 PDBsum 4V48 http://www.ebi.ac.uk/pdbsum/4V48 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5ADY http://www.ebi.ac.uk/pdbsum/5ADY PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5AKA http://www.ebi.ac.uk/pdbsum/5AKA PDBsum 5GAD http://www.ebi.ac.uk/pdbsum/5GAD PDBsum 5GAE http://www.ebi.ac.uk/pdbsum/5GAE PDBsum 5GAF http://www.ebi.ac.uk/pdbsum/5GAF PDBsum 5GAG http://www.ebi.ac.uk/pdbsum/5GAG PDBsum 5GAH http://www.ebi.ac.uk/pdbsum/5GAH PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PSORT swissprot:RL32_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RL32_ECOLI PSORT-B swissprot:RL32_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RL32_ECOLI PSORT2 swissprot:RL32_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RL32_ECOLI Pfam PF01783 http://pfam.xfam.org/family/PF01783 Phobius swissprot:RL32_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RL32_ECOLI PhylomeDB P0A7N4 http://phylomedb.org/?seqid=P0A7N4 ProteinModelPortal P0A7N4 http://www.proteinmodelportal.org/query/uniprot/P0A7N4 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 12809609 http://www.ncbi.nlm.nih.gov/pubmed/12809609 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2477362 http://www.ncbi.nlm.nih.gov/pubmed/2477362 PubMed 24844575 http://www.ncbi.nlm.nih.gov/pubmed/24844575 PubMed 25310980 http://www.ncbi.nlm.nih.gov/pubmed/25310980 PubMed 2665813 http://www.ncbi.nlm.nih.gov/pubmed/2665813 PubMed 765258 http://www.ncbi.nlm.nih.gov/pubmed/765258 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_415607 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415607 RefSeq WP_000290727 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000290727 SMR P0A7N4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7N4 STRING 511145.b1089 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1089&targetmode=cogs STRING COG0333 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0333&targetmode=cogs SUPFAM SSF57829 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF57829 TIGRFAMs TIGR01031 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01031 UniProtKB RL32_ECOLI http://www.uniprot.org/uniprot/RL32_ECOLI UniProtKB-AC P0A7N4 http://www.uniprot.org/uniprot/P0A7N4 charge swissprot:RL32_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RL32_ECOLI eggNOG COG0333 http://eggnogapi.embl.de/nog_data/html/tree/COG0333 epestfind swissprot:RL32_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RL32_ECOLI garnier swissprot:RL32_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RL32_ECOLI helixturnhelix swissprot:RL32_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RL32_ECOLI hmoment swissprot:RL32_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RL32_ECOLI iep swissprot:RL32_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RL32_ECOLI inforesidue swissprot:RL32_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RL32_ECOLI octanol swissprot:RL32_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RL32_ECOLI pepcoil swissprot:RL32_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RL32_ECOLI pepdigest swissprot:RL32_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RL32_ECOLI pepinfo swissprot:RL32_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RL32_ECOLI pepnet swissprot:RL32_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RL32_ECOLI pepstats swissprot:RL32_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RL32_ECOLI pepwheel swissprot:RL32_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RL32_ECOLI pepwindow swissprot:RL32_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RL32_ECOLI sigcleave swissprot:RL32_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RL32_ECOLI ## Database ID URL or Descriptions # AltName SRA_ECOLI 30S ribosomal protein S22 # BioGrid 4260209 7 # CAUTION Was originally thought to be a ribosomal protein. {ECO:0000305|PubMed 3553168}. # DISRUPTION PHENOTYPE Not essential, a quadruple raiA-hpf-rmf-sra knockout strain is significantly outcompeted by wild-type after 4 days growth (PubMed:17277072). {ECO 0000269|PubMed:17277072}. # EcoGene EG11508 sra # FUNCTION SRA_ECOLI Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein. {ECO 0000269|PubMed 11292794, ECO 0000269|PubMed 17277072}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0022627 cytosolic small ribosomal subunit; IDA:EcoCyc. # GO_function GO:0003735 structural constituent of ribosome; IEA:InterPro. # GO_process GO:0006412 translation; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_process GO:0006412 translation # INDUCTION SRA_ECOLI Induced upon entry into stationary phase, this is controlled at least in part by the RpoS sigma factor. # InterPro IPR012607 Ribosomal_S22 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=5095.9; Method=MALDI; Range=1-45; Evidence={ECO:0000269|PubMed 10094780}; # Organism SRA_ECOLI Escherichia coli (strain K12) # PATRIC 32118254 VBIEscCol129921_1547 # PIR C64901 C64901 # Pfam PF08136 Ribosomal_S22 # ProDom PD049510 Ribosomal_S22 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SRA_ECOLI Stationary-phase-induced ribosome-associated protein # RefSeq NP_415997 NC_000913.3 # RefSeq WP_000841554 NZ_LN832404.1 # SIMILARITY Belongs to the SRA family. {ECO 0000305}. # SUBCELLULAR LOCATION SRA_ECOLI Cytoplasm {ECO 0000269|PubMed 21903814}. Note=Enriched in the periphery of the cell, excluded from the nucleoid (PubMed 21903814). {ECO 0000269|PubMed 21903814}. # SUBUNIT Associates exclusively with the 30S subunit; there is 0.1 copy per ribosome in the exponential phase and 0.4 copies per ribosome in the stationary phase. This is also true for several other K12 derivatives and strain B/R. {ECO:0000269|PubMed 11292794}. # eggNOG ENOG4107AV5 Bacteria # eggNOG ENOG410XU1Y LUCA BLAST swissprot:SRA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SRA_ECOLI BioCyc ECOL316407:JW5962-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5962-MONOMER BioCyc EcoCyc:EG11508-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11508-MONOMER BioCyc MetaCyc:EG11508-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11508-MONOMER DIP DIP-48175N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48175N DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1204697 http://dx.doi.org/10.1126/science.1204697 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01713-06 http://dx.doi.org/10.1128/JB.01713-06 DOI 10.1128/JB.183.9.2765-2773.2001 http://dx.doi.org/10.1128/JB.183.9.2765-2773.2001 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D13179 http://www.ebi.ac.uk/ena/data/view/D13179 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X55956 http://www.ebi.ac.uk/ena/data/view/X55956 EchoBASE EB1471 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1471 EcoGene EG11508 http://www.ecogene.org/geneInfo.php?eg_id=EG11508 EnsemblBacteria AAC74553 http://www.ensemblgenomes.org/id/AAC74553 EnsemblBacteria AAC74553 http://www.ensemblgenomes.org/id/AAC74553 EnsemblBacteria BAE76452 http://www.ensemblgenomes.org/id/BAE76452 EnsemblBacteria BAE76452 http://www.ensemblgenomes.org/id/BAE76452 EnsemblBacteria BAE76452 http://www.ensemblgenomes.org/id/BAE76452 EnsemblBacteria b1480 http://www.ensemblgenomes.org/id/b1480 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0022627 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022627 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GeneID 946030 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946030 HOGENOM HOG000267917 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267917&db=HOGENOM6 IntAct P68191 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P68191* InterPro IPR012607 http://www.ebi.ac.uk/interpro/entry/IPR012607 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW5962 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5962 KEGG_Gene eco:b1480 http://www.genome.jp/dbget-bin/www_bget?eco:b1480 KEGG_Orthology KO:K02972 http://www.genome.jp/dbget-bin/www_bget?KO:K02972 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 MINT MINT-1322613 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1322613 PSORT swissprot:SRA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SRA_ECOLI PSORT-B swissprot:SRA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SRA_ECOLI PSORT2 swissprot:SRA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SRA_ECOLI Pfam PF08136 http://pfam.xfam.org/family/PF08136 Phobius swissprot:SRA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SRA_ECOLI ProteinModelPortal P68191 http://www.proteinmodelportal.org/query/uniprot/P68191 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 11292794 http://www.ncbi.nlm.nih.gov/pubmed/11292794 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17277072 http://www.ncbi.nlm.nih.gov/pubmed/17277072 PubMed 21903814 http://www.ncbi.nlm.nih.gov/pubmed/21903814 PubMed 2199308 http://www.ncbi.nlm.nih.gov/pubmed/2199308 PubMed 3553168 http://www.ncbi.nlm.nih.gov/pubmed/3553168 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415997 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415997 RefSeq WP_000841554 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000841554 STRING 511145.b1480 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1480&targetmode=cogs UniProtKB SRA_ECOLI http://www.uniprot.org/uniprot/SRA_ECOLI UniProtKB-AC P68191 http://www.uniprot.org/uniprot/P68191 charge swissprot:SRA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SRA_ECOLI eggNOG ENOG4107AV5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107AV5 eggNOG ENOG410XU1Y http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XU1Y epestfind swissprot:SRA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SRA_ECOLI garnier swissprot:SRA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SRA_ECOLI helixturnhelix swissprot:SRA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SRA_ECOLI hmoment swissprot:SRA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SRA_ECOLI iep swissprot:SRA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SRA_ECOLI inforesidue swissprot:SRA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SRA_ECOLI octanol swissprot:SRA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SRA_ECOLI pepcoil swissprot:SRA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SRA_ECOLI pepdigest swissprot:SRA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SRA_ECOLI pepinfo swissprot:SRA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SRA_ECOLI pepnet swissprot:SRA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SRA_ECOLI pepstats swissprot:SRA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SRA_ECOLI pepwheel swissprot:SRA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SRA_ECOLI pepwindow swissprot:SRA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SRA_ECOLI sigcleave swissprot:SRA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SRA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259552 18 # EcoGene EG12703 yccJ # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # IntAct P0AB14 6 # InterPro IPR025600 YccJ # Organism YCCJ_ECOLI Escherichia coli (strain K12) # PATRIC 32117231 VBIEscCol129921_1039 # PIR A64842 A64842 # Pfam PF13993 YccJ # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCCJ_ECOLI Uncharacterized protein YccJ # RefSeq NP_415523 NC_000913.3 # RefSeq WP_001143120 NZ_LN832404.1 # eggNOG ENOG4105XH3 Bacteria # eggNOG ENOG41124QP LUCA BLAST swissprot:YCCJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCCJ_ECOLI BioCyc ECOL316407:JW0988-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0988-MONOMER BioCyc EcoCyc:EG12703-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12703-MONOMER DIP DIP-47912N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47912N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1111/j.1574-6968.1998.tb13343.x http://dx.doi.org/10.1111/j.1574-6968.1998.tb13343.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M33807 http://www.ebi.ac.uk/ena/data/view/M33807 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2565 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2565 EcoGene EG12703 http://www.ecogene.org/geneInfo.php?eg_id=EG12703 EnsemblBacteria AAC74088 http://www.ensemblgenomes.org/id/AAC74088 EnsemblBacteria AAC74088 http://www.ensemblgenomes.org/id/AAC74088 EnsemblBacteria BAA35770 http://www.ensemblgenomes.org/id/BAA35770 EnsemblBacteria BAA35770 http://www.ensemblgenomes.org/id/BAA35770 EnsemblBacteria BAA35770 http://www.ensemblgenomes.org/id/BAA35770 EnsemblBacteria b1003 http://www.ensemblgenomes.org/id/b1003 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GeneID 948930 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948930 HOGENOM HOG000267892 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267892&db=HOGENOM6 IntAct P0AB14 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AB14* InterPro IPR025600 http://www.ebi.ac.uk/interpro/entry/IPR025600 KEGG_Gene ecj:JW0988 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0988 KEGG_Gene eco:b1003 http://www.genome.jp/dbget-bin/www_bget?eco:b1003 OMA QSKAHHV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QSKAHHV PSORT swissprot:YCCJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCCJ_ECOLI PSORT-B swissprot:YCCJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCCJ_ECOLI PSORT2 swissprot:YCCJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCCJ_ECOLI Pfam PF13993 http://pfam.xfam.org/family/PF13993 Phobius swissprot:YCCJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCCJ_ECOLI ProteinModelPortal P0AB14 http://www.proteinmodelportal.org/query/uniprot/P0AB14 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2153660 http://www.ncbi.nlm.nih.gov/pubmed/2153660 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9868784 http://www.ncbi.nlm.nih.gov/pubmed/9868784 RefSeq NP_415523 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415523 RefSeq WP_001143120 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001143120 SMR P0AB14 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AB14 STRING 511145.b1003 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1003&targetmode=cogs UniProtKB YCCJ_ECOLI http://www.uniprot.org/uniprot/YCCJ_ECOLI UniProtKB-AC P0AB14 http://www.uniprot.org/uniprot/P0AB14 charge swissprot:YCCJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCCJ_ECOLI eggNOG ENOG4105XH3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105XH3 eggNOG ENOG41124QP http://eggnogapi.embl.de/nog_data/html/tree/ENOG41124QP epestfind swissprot:YCCJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCCJ_ECOLI garnier swissprot:YCCJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCCJ_ECOLI helixturnhelix swissprot:YCCJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCCJ_ECOLI hmoment swissprot:YCCJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCCJ_ECOLI iep swissprot:YCCJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCCJ_ECOLI inforesidue swissprot:YCCJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCCJ_ECOLI octanol swissprot:YCCJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCCJ_ECOLI pepcoil swissprot:YCCJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCCJ_ECOLI pepdigest swissprot:YCCJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCCJ_ECOLI pepinfo swissprot:YCCJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCCJ_ECOLI pepnet swissprot:YCCJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCCJ_ECOLI pepstats swissprot:YCCJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCCJ_ECOLI pepwheel swissprot:YCCJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCCJ_ECOLI pepwindow swissprot:YCCJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCCJ_ECOLI sigcleave swissprot:YCCJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCCJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4259496 3 # DISRUPTION PHENOTYPE Disruption suppresses an rpoE disruption; in a wild-type background disruption down-regulates extracytoplasmic stress responses and outer membrane vesicle production. {ECO:0000269|PubMed 17172327}. # EcoGene EG13760 hicB # FUNCTION HICB_ECOLI Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin; overexpression prevents HicA-mediated cessation of cell growth and inhibition of cell proliferation. {ECO 0000269|PubMed 19060138}. # GO_function GO:0043565 sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.260.40 -; 1. # INDUCTION Induced by amino acid starvation, carbon starvation and when translation is blocked. Induction no longer occurs in the absence of Lon protease suggesting, by homology to other toxin- antitoxin systems, that Lon may degrade the HicB antitoxin. A member of the hicA-hicB operon. {ECO:0000269|PubMed 19060138}. # InterPro IPR001387 Cro/C1-type_HTH # InterPro IPR010982 Lambda_DNA-bd_dom # InterPro IPR031807 HicB-like # Organism HICB_ECOLI Escherichia coli (strain K12) # PATRIC 32118166 VBIEscCol129921_1503 # PIR A64896 A64896 # PROSITE PS50943 HTH_CROC1 # PTM HICB_ECOLI May be degraded by Lon protease. {ECO 0000250}. # Pfam PF01381 HTH_3 # Pfam PF15919 HicB_lk_antitox # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HICB_ECOLI Antitoxin HicB # RefSeq NP_415955 NC_000913.3 # SEQUENCE CAUTION Sequence=BAE76439.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the HicB antitoxin family. {ECO 0000305}. # SIMILARITY Contains 1 HTH cro/C1-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00257}. # SMART SM00530 HTH_XRE # SUBUNIT Probably forms a complex with the mRNA interferase HicA; when the 2 dissociate the mRNA interferase becomes active. {ECO 0000250}. # SUPFAM SSF47413 SSF47413 # eggNOG COG1598 LUCA # eggNOG ENOG4105PF0 Bacteria BLAST swissprot:HICB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HICB_ECOLI BioCyc ECOL316407:JW1433-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1433-MONOMER BioCyc EcoCyc:G6749-MONOMER http://biocyc.org/getid?id=EcoCyc:G6749-MONOMER DIP DIP-48269N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48269N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/bioinformatics/btl418 http://dx.doi.org/10.1093/bioinformatics/btl418 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01013-08 http://dx.doi.org/10.1128/JB.01013-08 DOI 10.1128/JB.01534-06 http://dx.doi.org/10.1128/JB.01534-06 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3523 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3523 EcoGene EG13760 http://www.ecogene.org/geneInfo.php?eg_id=EG13760 EnsemblBacteria AAC74520 http://www.ensemblgenomes.org/id/AAC74520 EnsemblBacteria AAC74520 http://www.ensemblgenomes.org/id/AAC74520 EnsemblBacteria BAE76439 http://www.ensemblgenomes.org/id/BAE76439 EnsemblBacteria BAE76439 http://www.ensemblgenomes.org/id/BAE76439 EnsemblBacteria BAE76439 http://www.ensemblgenomes.org/id/BAE76439 EnsemblBacteria b1438 http://www.ensemblgenomes.org/id/b1438 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.260.40 http://www.cathdb.info/version/latest/superfamily/1.10.260.40 GeneID 946001 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946001 HOGENOM HOG000219259 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219259&db=HOGENOM6 IntAct P67697 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P67697* InterPro IPR001387 http://www.ebi.ac.uk/interpro/entry/IPR001387 InterPro IPR010982 http://www.ebi.ac.uk/interpro/entry/IPR010982 InterPro IPR031807 http://www.ebi.ac.uk/interpro/entry/IPR031807 KEGG_Gene ecj:JW1433 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1433 KEGG_Gene eco:b1438 http://www.genome.jp/dbget-bin/www_bget?eco:b1438 OMA AMEFYFE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AMEFYFE PROSITE PS50943 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50943 PSORT swissprot:HICB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HICB_ECOLI PSORT-B swissprot:HICB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HICB_ECOLI PSORT2 swissprot:HICB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HICB_ECOLI Pfam PF01381 http://pfam.xfam.org/family/PF01381 Pfam PF15919 http://pfam.xfam.org/family/PF15919 Phobius swissprot:HICB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HICB_ECOLI ProteinModelPortal P67697 http://www.proteinmodelportal.org/query/uniprot/P67697 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16895922 http://www.ncbi.nlm.nih.gov/pubmed/16895922 PubMed 17172327 http://www.ncbi.nlm.nih.gov/pubmed/17172327 PubMed 19060138 http://www.ncbi.nlm.nih.gov/pubmed/19060138 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415955 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415955 SMART SM00530 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00530 STRING 511145.b1438 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1438&targetmode=cogs SUPFAM SSF47413 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47413 UniProtKB HICB_ECOLI http://www.uniprot.org/uniprot/HICB_ECOLI UniProtKB-AC P67697 http://www.uniprot.org/uniprot/P67697 charge swissprot:HICB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HICB_ECOLI eggNOG COG1598 http://eggnogapi.embl.de/nog_data/html/tree/COG1598 eggNOG ENOG4105PF0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105PF0 epestfind swissprot:HICB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HICB_ECOLI garnier swissprot:HICB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HICB_ECOLI helixturnhelix swissprot:HICB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HICB_ECOLI hmoment swissprot:HICB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HICB_ECOLI iep swissprot:HICB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HICB_ECOLI inforesidue swissprot:HICB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HICB_ECOLI octanol swissprot:HICB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HICB_ECOLI pepcoil swissprot:HICB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HICB_ECOLI pepdigest swissprot:HICB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HICB_ECOLI pepinfo swissprot:HICB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HICB_ECOLI pepnet swissprot:HICB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HICB_ECOLI pepstats swissprot:HICB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HICB_ECOLI pepwheel swissprot:HICB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HICB_ECOLI pepwindow swissprot:HICB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HICB_ECOLI sigcleave swissprot:HICB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HICB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260444 239 # CATALYTIC ACTIVITY YEHU_ECOLI ATP + protein L-histidine = ADP + protein N- phospho-L-histidine. # DISRUPTION PHENOTYPE Deletion of yehUT has no obvious phenotypic effect under the conditions tested. {ECO:0000269|PubMed 22685278}. # EcoGene EG12007 yehU # FUNCTION YEHU_ECOLI Member of the two-component regulatory system YehU/YehT, which may be involved in the stationary-phase control network. Activates YehT by phosphorylation. {ECO 0000269|PubMed 15522865, ECO 0000269|PubMed 22685278}. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; ISM:EcoCyc. # GO_function GO:0000155 phosphorelay sensor kinase activity; IEA:InterPro. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0000160 phosphorelay signal transduction system; IMP:EcoCyc. # GO_process GO:0018106 peptidyl-histidine phosphorylation; IMP:EcoCyc. # GO_process GO:0071555 cell wall organization; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005622 intracellular # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 3.30.450.40 -; 1. # Gene3D 3.30.565.10 -; 1. # InterPro IPR003018 GAF # InterPro IPR003594 HATPase_C # InterPro IPR010559 Sig_transdc_His_kin_internal # InterPro IPR011620 Sig_transdc_His_kinase_LytS_TM # InterPro IPR029016 GAF_dom-like # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01001 Protein kinases # KEGG_Brite ko02022 Two-component system # Organism YEHU_ECOLI Escherichia coli (strain K12) # PATRIC 32119589 VBIEscCol129921_2205 # PIR E64980 E64980 # PTM YEHU_ECOLI Autophosphorylated. # Pfam PF06580 His_kinase # Pfam PF07694 5TM-5TMR_LYT # Pfam PF13492 GAF_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEHU_ECOLI Sensor histidine kinase YehU # RefSeq NP_416630 NC_000913.3 # RefSeq WP_001295431 NZ_LN832404.1 # SIMILARITY Contains 1 histidine kinase domain. {ECO 0000305}. # SMART SM00065 GAF # SUBCELLULAR LOCATION YEHU_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # SUPFAM SSF55781 SSF55781 # SUPFAM SSF55874 SSF55874 # eggNOG COG3275 LUCA # eggNOG ENOG4108HRK Bacteria BLAST swissprot:YEHU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEHU_ECOLI BioCyc ECOL316407:JW5353-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5353-MONOMER BioCyc EcoCyc:EG12007-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12007-MONOMER COG COG3275 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3275 DIP DIP-11909N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11909N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M410104200 http://dx.doi.org/10.1074/jbc.M410104200 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00409-12 http://dx.doi.org/10.1128/JB.00409-12 EC_number EC:2.7.13.3 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.13.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.13.3 http://enzyme.expasy.org/EC/2.7.13.3 EchoBASE EB1945 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1945 EcoGene EG12007 http://www.ecogene.org/geneInfo.php?eg_id=EG12007 EnsemblBacteria AAC75187 http://www.ensemblgenomes.org/id/AAC75187 EnsemblBacteria AAC75187 http://www.ensemblgenomes.org/id/AAC75187 EnsemblBacteria BAE76602 http://www.ensemblgenomes.org/id/BAE76602 EnsemblBacteria BAE76602 http://www.ensemblgenomes.org/id/BAE76602 EnsemblBacteria BAE76602 http://www.ensemblgenomes.org/id/BAE76602 EnsemblBacteria b2126 http://www.ensemblgenomes.org/id/b2126 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0000155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000155 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0018106 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018106 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 3.30.450.40 http://www.cathdb.info/version/latest/superfamily/3.30.450.40 Gene3D 3.30.565.10 http://www.cathdb.info/version/latest/superfamily/3.30.565.10 GeneID 949027 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949027 HOGENOM HOG000242219 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000242219&db=HOGENOM6 InParanoid P0AD14 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AD14 IntEnz 2.7.13.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.13.3 InterPro IPR003018 http://www.ebi.ac.uk/interpro/entry/IPR003018 InterPro IPR003594 http://www.ebi.ac.uk/interpro/entry/IPR003594 InterPro IPR010559 http://www.ebi.ac.uk/interpro/entry/IPR010559 InterPro IPR011620 http://www.ebi.ac.uk/interpro/entry/IPR011620 InterPro IPR029016 http://www.ebi.ac.uk/interpro/entry/IPR029016 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01001 http://www.genome.jp/dbget-bin/www_bget?ko01001 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW5353 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5353 KEGG_Gene eco:b2126 http://www.genome.jp/dbget-bin/www_bget?eco:b2126 KEGG_Orthology KO:K02478 http://www.genome.jp/dbget-bin/www_bget?KO:K02478 OMA SHFFRSN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SHFFRSN PSORT swissprot:YEHU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEHU_ECOLI PSORT-B swissprot:YEHU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEHU_ECOLI PSORT2 swissprot:YEHU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEHU_ECOLI Pfam PF06580 http://pfam.xfam.org/family/PF06580 Pfam PF07694 http://pfam.xfam.org/family/PF07694 Pfam PF13492 http://pfam.xfam.org/family/PF13492 Phobius swissprot:YEHU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEHU_ECOLI PhylomeDB P0AD14 http://phylomedb.org/?seqid=P0AD14 ProteinModelPortal P0AD14 http://www.proteinmodelportal.org/query/uniprot/P0AD14 PubMed 15522865 http://www.ncbi.nlm.nih.gov/pubmed/15522865 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22685278 http://www.ncbi.nlm.nih.gov/pubmed/22685278 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416630 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416630 RefSeq WP_001295431 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295431 SMART SM00065 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00065 SMR P0AD14 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AD14 STRING 511145.b2126 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2126&targetmode=cogs STRING COG3275 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3275&targetmode=cogs SUPFAM SSF55781 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55781 SUPFAM SSF55874 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55874 UniProtKB YEHU_ECOLI http://www.uniprot.org/uniprot/YEHU_ECOLI UniProtKB-AC P0AD14 http://www.uniprot.org/uniprot/P0AD14 charge swissprot:YEHU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEHU_ECOLI eggNOG COG3275 http://eggnogapi.embl.de/nog_data/html/tree/COG3275 eggNOG ENOG4108HRK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108HRK epestfind swissprot:YEHU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEHU_ECOLI garnier swissprot:YEHU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEHU_ECOLI helixturnhelix swissprot:YEHU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEHU_ECOLI hmoment swissprot:YEHU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEHU_ECOLI iep swissprot:YEHU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEHU_ECOLI inforesidue swissprot:YEHU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEHU_ECOLI octanol swissprot:YEHU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEHU_ECOLI pepcoil swissprot:YEHU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEHU_ECOLI pepdigest swissprot:YEHU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEHU_ECOLI pepinfo swissprot:YEHU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEHU_ECOLI pepnet swissprot:YEHU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEHU_ECOLI pepstats swissprot:YEHU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEHU_ECOLI pepwheel swissprot:YEHU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEHU_ECOLI pepwindow swissprot:YEHU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEHU_ECOLI sigcleave swissprot:YEHU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEHU_ECOLI ## Database ID URL or Descriptions # AltName ACRD_ECOLI Acriflavine resistance protein D # BioGrid 4260927 486 # EcoGene EG10014 acrD # FUNCTION ACRD_ECOLI Participates in the efflux of aminoglycosides. Confers resistance to a variety of these substances. {ECO 0000269|PubMed 10692383}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function ACRD_ECOLI GO 0015307 drug proton antiporter activity; IDA EcoCyc. # GO_function GO:0015238 drug transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0006855 drug transmembrane transport; IMP:EcoCyc. # GO_process GO:0042493 response to drug; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0055085 transmembrane transport # Gene3D 3.30.2090.10 -; 2. # IntAct P24177 4 # InterPro IPR001036 Acrflvin-R # InterPro IPR004764 HAE1 # InterPro IPR027463 AcrB_DN_DC_subdom # Organism ACRD_ECOLI Escherichia coli (strain K12) # PATRIC 32120323 VBIEscCol129921_2564 # PIR E65022 E65022 # PRINTS PR00702 ACRIFLAVINRP # Pfam PF00873 ACR_tran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ACRD_ECOLI Probable aminoglycoside efflux pump # RefSeq NP_416965 NC_000913.3 # RefSeq WP_001273151 NZ_LN832404.1 # SIMILARITY Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. {ECO 0000305}. # SUBCELLULAR LOCATION ACRD_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # SUPFAM SSF82714 SSF82714; 2 # TCDB 2.A.6.2 the resistance-nodulation-cell division (rnd) superfamily # TIGRFAMs TIGR00915 2A0602 # eggNOG COG0841 LUCA # eggNOG ENOG4105BZS Bacteria BLAST swissprot:ACRD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ACRD_ECOLI BioCyc ECOL316407:JW2454-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2454-MONOMER BioCyc EcoCyc:ACRD-MONOMER http://biocyc.org/getid?id=EcoCyc:ACRD-MONOMER COG COG0841 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0841 DIP DIP-9050N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9050N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.6.1754-1756.2000 http://dx.doi.org/10.1128/JB.182.6.1754-1756.2000 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U10436 http://www.ebi.ac.uk/ena/data/view/U10436 EMBL U12598 http://www.ebi.ac.uk/ena/data/view/U12598 EMBL X57403 http://www.ebi.ac.uk/ena/data/view/X57403 EchoBASE EB0014 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0014 EcoGene EG10014 http://www.ecogene.org/geneInfo.php?eg_id=EG10014 EnsemblBacteria AAC75523 http://www.ensemblgenomes.org/id/AAC75523 EnsemblBacteria AAC75523 http://www.ensemblgenomes.org/id/AAC75523 EnsemblBacteria BAA16344 http://www.ensemblgenomes.org/id/BAA16344 EnsemblBacteria BAA16344 http://www.ensemblgenomes.org/id/BAA16344 EnsemblBacteria BAA16344 http://www.ensemblgenomes.org/id/BAA16344 EnsemblBacteria b2470 http://www.ensemblgenomes.org/id/b2470 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015238 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015238 GO_function GO:0015307 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015307 GO_process GO:0006855 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006855 GO_process GO:0042493 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 3.30.2090.10 http://www.cathdb.info/version/latest/superfamily/3.30.2090.10 GeneID 945464 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945464 HOGENOM HOG000158129 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000158129&db=HOGENOM6 InParanoid P24177 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P24177 IntAct P24177 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P24177* InterPro IPR001036 http://www.ebi.ac.uk/interpro/entry/IPR001036 InterPro IPR004764 http://www.ebi.ac.uk/interpro/entry/IPR004764 InterPro IPR027463 http://www.ebi.ac.uk/interpro/entry/IPR027463 KEGG_Gene ecj:JW2454 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2454 KEGG_Gene eco:b2470 http://www.genome.jp/dbget-bin/www_bget?eco:b2470 KEGG_Orthology KO:K03296 http://www.genome.jp/dbget-bin/www_bget?KO:K03296 MINT MINT-1256458 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1256458 OMA HRSLRWM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HRSLRWM PRINTS PR00702 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00702 PSORT swissprot:ACRD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ACRD_ECOLI PSORT-B swissprot:ACRD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ACRD_ECOLI PSORT2 swissprot:ACRD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ACRD_ECOLI Pfam PF00873 http://pfam.xfam.org/family/PF00873 Phobius swissprot:ACRD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ACRD_ECOLI PhylomeDB P24177 http://phylomedb.org/?seqid=P24177 ProteinModelPortal P24177 http://www.proteinmodelportal.org/query/uniprot/P24177 PubMed 10692383 http://www.ncbi.nlm.nih.gov/pubmed/10692383 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 1644752 http://www.ncbi.nlm.nih.gov/pubmed/1644752 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416965 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416965 RefSeq WP_001273151 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001273151 SMR P24177 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P24177 STRING 511145.b2470 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2470&targetmode=cogs STRING COG0841 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0841&targetmode=cogs SUPFAM SSF82714 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF82714 TCDB 2.A.6.2 http://www.tcdb.org/search/result.php?tc=2.A.6.2 TIGRFAMs TIGR00915 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00915 UniProtKB ACRD_ECOLI http://www.uniprot.org/uniprot/ACRD_ECOLI UniProtKB-AC P24177 http://www.uniprot.org/uniprot/P24177 charge swissprot:ACRD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ACRD_ECOLI eggNOG COG0841 http://eggnogapi.embl.de/nog_data/html/tree/COG0841 eggNOG ENOG4105BZS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZS epestfind swissprot:ACRD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ACRD_ECOLI garnier swissprot:ACRD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ACRD_ECOLI helixturnhelix swissprot:ACRD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ACRD_ECOLI hmoment swissprot:ACRD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ACRD_ECOLI iep swissprot:ACRD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ACRD_ECOLI inforesidue swissprot:ACRD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ACRD_ECOLI octanol swissprot:ACRD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ACRD_ECOLI pepcoil swissprot:ACRD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ACRD_ECOLI pepdigest swissprot:ACRD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ACRD_ECOLI pepinfo swissprot:ACRD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ACRD_ECOLI pepnet swissprot:ACRD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ACRD_ECOLI pepstats swissprot:ACRD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ACRD_ECOLI pepwheel swissprot:ACRD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ACRD_ECOLI pepwindow swissprot:ACRD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ACRD_ECOLI sigcleave swissprot:ACRD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ACRD_ECOLI ## Database ID URL or Descriptions # BioGrid 4263147 12 # DISRUPTION PHENOTYPE Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain. {ECO:0000269|PubMed 20345943}. # EcoGene EG12388 sfmF # FUNCTION SFMF_ECOLI Part of the sfmACDHF fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes. {ECO 0000269|PubMed 20345943}. # GO_component GO:0009289 pilus; IEA:UniProtKB-SubCell. # GO_process GO:0007155 cell adhesion; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0007155 cell adhesion # Gene3D 2.60.40.1090 -; 1. # INDUCTION Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression. {ECO:0000269|PubMed 20345943}. # InterPro IPR000259 Adhesion_dom_fimbrial # InterPro IPR008966 Adhesion_dom # KEGG_Brite ko02035 Bacterial motility proteins # MISCELLANEOUS The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed. {ECO:0000305|PubMed 20345943}. # Organism SFMF_ECOLI Escherichia coli (strain K12) # PATRIC 32116228 VBIEscCol129921_0555 # PIR E64785 E64785 # Pfam PF00419 Fimbrial # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SFMF_ECOLI Uncharacterized fimbrial-like protein SfmF # RefSeq NP_415067 NC_000913.3 # RefSeq WP_001255230 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40732.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the fimbrial protein family. {ECO 0000305}. # SUBCELLULAR LOCATION SFMF_ECOLI Fimbrium {ECO 0000250}. # SUPFAM SSF49401 SSF49401 # eggNOG ENOG4108ZI2 Bacteria # eggNOG ENOG4111SMY LUCA BLAST swissprot:SFMF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SFMF_ECOLI BioCyc ECOL316407:JW5072-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5072-MONOMER BioCyc EcoCyc:EG12388-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12388-MONOMER COG COG3539 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3539 DOI 10.1007/BF00260503 http://dx.doi.org/10.1007/BF00260503 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1111/j.1462-2920.2010.02202.x http://dx.doi.org/10.1111/j.1462-2920.2010.02202.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EMBL X51662 http://www.ebi.ac.uk/ena/data/view/X51662 EchoBASE EB2289 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2289 EcoGene EG12388 http://www.ecogene.org/geneInfo.php?eg_id=EG12388 EnsemblBacteria AAC73636 http://www.ensemblgenomes.org/id/AAC73636 EnsemblBacteria AAC73636 http://www.ensemblgenomes.org/id/AAC73636 EnsemblBacteria BAE76311 http://www.ensemblgenomes.org/id/BAE76311 EnsemblBacteria BAE76311 http://www.ensemblgenomes.org/id/BAE76311 EnsemblBacteria BAE76311 http://www.ensemblgenomes.org/id/BAE76311 EnsemblBacteria b0534 http://www.ensemblgenomes.org/id/b0534 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009289 GO_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 Gene3D 2.60.40.1090 http://www.cathdb.info/version/latest/superfamily/2.60.40.1090 GeneID 944977 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944977 HOGENOM HOG000260127 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260127&db=HOGENOM6 InParanoid P38052 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P38052 InterPro IPR000259 http://www.ebi.ac.uk/interpro/entry/IPR000259 InterPro IPR008966 http://www.ebi.ac.uk/interpro/entry/IPR008966 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW5072 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5072 KEGG_Gene eco:b0534 http://www.genome.jp/dbget-bin/www_bget?eco:b0534 KEGG_Orthology KO:K07355 http://www.genome.jp/dbget-bin/www_bget?KO:K07355 OMA PHYLIRI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PHYLIRI PSORT swissprot:SFMF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SFMF_ECOLI PSORT-B swissprot:SFMF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SFMF_ECOLI PSORT2 swissprot:SFMF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SFMF_ECOLI Pfam PF00419 http://pfam.xfam.org/family/PF00419 Phobius swissprot:SFMF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SFMF_ECOLI PhylomeDB P38052 http://phylomedb.org/?seqid=P38052 ProteinModelPortal P38052 http://www.proteinmodelportal.org/query/uniprot/P38052 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20345943 http://www.ncbi.nlm.nih.gov/pubmed/20345943 PubMed 2183007 http://www.ncbi.nlm.nih.gov/pubmed/2183007 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415067 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415067 RefSeq WP_001255230 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001255230 SMR P38052 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P38052 STRING 511145.b0534 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0534&targetmode=cogs STRING COG3539 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3539&targetmode=cogs SUPFAM SSF49401 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49401 UniProtKB SFMF_ECOLI http://www.uniprot.org/uniprot/SFMF_ECOLI UniProtKB-AC P38052 http://www.uniprot.org/uniprot/P38052 charge swissprot:SFMF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SFMF_ECOLI eggNOG ENOG4108ZI2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZI2 eggNOG ENOG4111SMY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111SMY epestfind swissprot:SFMF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SFMF_ECOLI garnier swissprot:SFMF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SFMF_ECOLI helixturnhelix swissprot:SFMF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SFMF_ECOLI hmoment swissprot:SFMF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SFMF_ECOLI iep swissprot:SFMF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SFMF_ECOLI inforesidue swissprot:SFMF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SFMF_ECOLI octanol swissprot:SFMF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SFMF_ECOLI pepcoil swissprot:SFMF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SFMF_ECOLI pepdigest swissprot:SFMF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SFMF_ECOLI pepinfo swissprot:SFMF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SFMF_ECOLI pepnet swissprot:SFMF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SFMF_ECOLI pepstats swissprot:SFMF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SFMF_ECOLI pepwheel swissprot:SFMF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SFMF_ECOLI pepwindow swissprot:SFMF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SFMF_ECOLI sigcleave swissprot:SFMF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SFMF_ECOLI ## Database ID URL or Descriptions # BioGrid 4261667 268 # EcoGene EG11764 yibH # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0055085 transmembrane transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006950 response to stress # GOslim_process GO:0055085 transmembrane transport # InterPro IPR006143 RND_pump_MFP # InterPro IPR032317 HlyD_D23 # Organism YIBH_ECOLI Escherichia coli (strain K12) # PATRIC 32122677 VBIEscCol129921_3715 # PIR S47818 S47818 # Pfam PF00529 HlyD # Pfam PF16576 HlyD_D23 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIBH_ECOLI Inner membrane protein YibH # RefSeq NP_418054 NC_000913.3 # RefSeq WP_000364939 NZ_CP014272.1 # SIMILARITY Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. {ECO 0000305}. # SUBCELLULAR LOCATION YIBH_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG COG1566 LUCA # eggNOG ENOG4105EFX Bacteria BLAST swissprot:YIBH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIBH_ECOLI BioCyc ECOL316407:JW3571-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3571-MONOMER BioCyc EcoCyc:EG11764-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11764-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19044 http://www.ebi.ac.uk/ena/data/view/L19044 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1714 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1714 EcoGene EG11764 http://www.ecogene.org/geneInfo.php?eg_id=EG11764 EnsemblBacteria AAC76621 http://www.ensemblgenomes.org/id/AAC76621 EnsemblBacteria AAC76621 http://www.ensemblgenomes.org/id/AAC76621 EnsemblBacteria BAE77696 http://www.ensemblgenomes.org/id/BAE77696 EnsemblBacteria BAE77696 http://www.ensemblgenomes.org/id/BAE77696 EnsemblBacteria BAE77696 http://www.ensemblgenomes.org/id/BAE77696 EnsemblBacteria b3597 http://www.ensemblgenomes.org/id/b3597 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 948110 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948110 HOGENOM HOG000279244 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000279244&db=HOGENOM6 InParanoid P0AFV0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFV0 InterPro IPR006143 http://www.ebi.ac.uk/interpro/entry/IPR006143 InterPro IPR032317 http://www.ebi.ac.uk/interpro/entry/IPR032317 KEGG_Gene ecj:JW3571 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3571 KEGG_Gene eco:b3597 http://www.genome.jp/dbget-bin/www_bget?eco:b3597 OMA YTAICIA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YTAICIA PSORT swissprot:YIBH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIBH_ECOLI PSORT-B swissprot:YIBH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIBH_ECOLI PSORT2 swissprot:YIBH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIBH_ECOLI Pfam PF00529 http://pfam.xfam.org/family/PF00529 Pfam PF16576 http://pfam.xfam.org/family/PF16576 Phobius swissprot:YIBH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIBH_ECOLI PhylomeDB P0AFV0 http://phylomedb.org/?seqid=P0AFV0 ProteinModelPortal P0AFV0 http://www.proteinmodelportal.org/query/uniprot/P0AFV0 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 8387990 http://www.ncbi.nlm.nih.gov/pubmed/8387990 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418054 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418054 RefSeq WP_000364939 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000364939 SMR P0AFV0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFV0 STRING 511145.b3597 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3597&targetmode=cogs UniProtKB YIBH_ECOLI http://www.uniprot.org/uniprot/YIBH_ECOLI UniProtKB-AC P0AFV0 http://www.uniprot.org/uniprot/P0AFV0 charge swissprot:YIBH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIBH_ECOLI eggNOG COG1566 http://eggnogapi.embl.de/nog_data/html/tree/COG1566 eggNOG ENOG4105EFX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EFX epestfind swissprot:YIBH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIBH_ECOLI garnier swissprot:YIBH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIBH_ECOLI helixturnhelix swissprot:YIBH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIBH_ECOLI hmoment swissprot:YIBH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIBH_ECOLI iep swissprot:YIBH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIBH_ECOLI inforesidue swissprot:YIBH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIBH_ECOLI octanol swissprot:YIBH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIBH_ECOLI pepcoil swissprot:YIBH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIBH_ECOLI pepdigest swissprot:YIBH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIBH_ECOLI pepinfo swissprot:YIBH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIBH_ECOLI pepnet swissprot:YIBH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIBH_ECOLI pepstats swissprot:YIBH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIBH_ECOLI pepwheel swissprot:YIBH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIBH_ECOLI pepwindow swissprot:YIBH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIBH_ECOLI sigcleave swissprot:YIBH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIBH_ECOLI ## Database ID URL or Descriptions # BioGrid 4263091 115 # EcoGene EG10714 phnD # FUNCTION PHND_ECOLI Phosphonate binding protein that is part of the phosphonate uptake system. Exhibits high affinity for 2- aminoethylphosphonate, and somewhat less affinity to ethylphosphonate, methylphosphonate, phosphonoacetate and phenylphosphonate. {ECO 0000269|PubMed 16751609}. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IEA:InterPro. # GO_function GO:0042917 alkylphosphonate transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0042916 alkylphosphonate transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043234 protein complex # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # IntAct P16682 3 # InterPro IPR005770 PhnD # InterPro IPR017797 Phosphnate-bd # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00223 Phosphonate transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # MISCELLANEOUS PHND_ECOLI The sequence shown is that of strain K12. # Organism PHND_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30043:SF4 PTHR30043:SF4; 3 # PATRIC 32123769 VBIEscCol129921_4233 # PIR S56333 S56333 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PHND_ECOLI Phosphonates-binding periplasmic protein # RefSeq NP_418529 NC_000913.3 # RefSeq WP_000992002 NZ_LN832404.1 # SUBCELLULAR LOCATION PHND_ECOLI Periplasm {ECO 0000305}. # SUBUNIT The complex is composed of two ATP-binding proteins (PhnC), two transmembrane proteins (PhnE) and a solute-binding protein (PhnD). {ECO 0000305}. # TCDB 3.A.1.9 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR01098 3A0109s03R # TIGRFAMs TIGR03431 PhnD # eggNOG COG3221 LUCA # eggNOG ENOG4105EHI Bacteria BLAST swissprot:PHND_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PHND_ECOLI BioCyc ECOL316407:JW4066-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4066-MONOMER BioCyc EcoCyc:PHND-MONOMER http://biocyc.org/getid?id=EcoCyc:PHND-MONOMER BioCyc MetaCyc:PHND-MONOMER http://biocyc.org/getid?id=MetaCyc:PHND-MONOMER COG COG3221 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3221 DIP DIP-10483N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10483N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1110/ps.062135206 http://dx.doi.org/10.1110/ps.062135206 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D90227 http://www.ebi.ac.uk/ena/data/view/D90227 EMBL J05260 http://www.ebi.ac.uk/ena/data/view/J05260 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB0708 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0708 EcoGene EG10714 http://www.ecogene.org/geneInfo.php?eg_id=EG10714 EnsemblBacteria AAC77066 http://www.ensemblgenomes.org/id/AAC77066 EnsemblBacteria AAC77066 http://www.ensemblgenomes.org/id/AAC77066 EnsemblBacteria BAE78107 http://www.ensemblgenomes.org/id/BAE78107 EnsemblBacteria BAE78107 http://www.ensemblgenomes.org/id/BAE78107 EnsemblBacteria BAE78107 http://www.ensemblgenomes.org/id/BAE78107 EnsemblBacteria b4105 http://www.ensemblgenomes.org/id/b4105 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0042917 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042917 GO_process GO:0042916 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042916 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948624 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948624 HOGENOM HOG000284940 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000284940&db=HOGENOM6 InParanoid P16682 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P16682 IntAct P16682 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P16682* InterPro IPR005770 http://www.ebi.ac.uk/interpro/entry/IPR005770 InterPro IPR017797 http://www.ebi.ac.uk/interpro/entry/IPR017797 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW4066 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4066 KEGG_Gene eco:b4105 http://www.genome.jp/dbget-bin/www_bget?eco:b4105 KEGG_Orthology KO:K02044 http://www.genome.jp/dbget-bin/www_bget?KO:K02044 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA SSHEVNA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SSHEVNA PANTHER PTHR30043:SF4 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30043:SF4 PSORT swissprot:PHND_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PHND_ECOLI PSORT-B swissprot:PHND_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PHND_ECOLI PSORT2 swissprot:PHND_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PHND_ECOLI Phobius swissprot:PHND_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PHND_ECOLI PhylomeDB P16682 http://phylomedb.org/?seqid=P16682 ProteinModelPortal P16682 http://www.proteinmodelportal.org/query/uniprot/P16682 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16751609 http://www.ncbi.nlm.nih.gov/pubmed/16751609 PubMed 1840580 http://www.ncbi.nlm.nih.gov/pubmed/1840580 PubMed 2155230 http://www.ncbi.nlm.nih.gov/pubmed/2155230 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418529 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418529 RefSeq WP_000992002 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000992002 STRING 511145.b4105 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4105&targetmode=cogs STRING COG3221 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3221&targetmode=cogs TCDB 3.A.1.9 http://www.tcdb.org/search/result.php?tc=3.A.1.9 TIGRFAMs TIGR01098 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01098 TIGRFAMs TIGR03431 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03431 UniProtKB PHND_ECOLI http://www.uniprot.org/uniprot/PHND_ECOLI UniProtKB-AC P16682 http://www.uniprot.org/uniprot/P16682 charge swissprot:PHND_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PHND_ECOLI eggNOG COG3221 http://eggnogapi.embl.de/nog_data/html/tree/COG3221 eggNOG ENOG4105EHI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EHI epestfind swissprot:PHND_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PHND_ECOLI garnier swissprot:PHND_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PHND_ECOLI helixturnhelix swissprot:PHND_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PHND_ECOLI hmoment swissprot:PHND_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PHND_ECOLI iep swissprot:PHND_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PHND_ECOLI inforesidue swissprot:PHND_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PHND_ECOLI octanol swissprot:PHND_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PHND_ECOLI pepcoil swissprot:PHND_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PHND_ECOLI pepdigest swissprot:PHND_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PHND_ECOLI pepinfo swissprot:PHND_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PHND_ECOLI pepnet swissprot:PHND_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PHND_ECOLI pepstats swissprot:PHND_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PHND_ECOLI pepwheel swissprot:PHND_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PHND_ECOLI pepwindow swissprot:PHND_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PHND_ECOLI sigcleave swissprot:PHND_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PHND_ECOLI ## Database ID URL or Descriptions # BioGrid 4262920 10 # EcoGene EG12214 yhhN # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR012506 YhhN # Organism YHHN_ECOLI Escherichia coli (strain K12) # PATRIC 32122380 VBIEscCol129921_3567 # PIR S47687 S47687 # Pfam PF07947 YhhN # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHHN_ECOLI Uncharacterized membrane protein YhhN # RefSeq NP_417925 NC_000913.3 # RefSeq WP_000964718 NZ_LN832404.1 # SIMILARITY Belongs to the TMEM86 family. {ECO 0000305}. # SUBCELLULAR LOCATION YHHN_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # eggNOG COG3714 LUCA # eggNOG ENOG4107FS9 Bacteria BLAST swissprot:YHHN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHHN_ECOLI BioCyc ECOL316407:JW3433-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3433-MONOMER BioCyc EcoCyc:EG12214-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12214-MONOMER DIP DIP-12351N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12351N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2128 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2128 EcoGene EG12214 http://www.ecogene.org/geneInfo.php?eg_id=EG12214 EnsemblBacteria AAC76493 http://www.ensemblgenomes.org/id/AAC76493 EnsemblBacteria AAC76493 http://www.ensemblgenomes.org/id/AAC76493 EnsemblBacteria BAE77825 http://www.ensemblgenomes.org/id/BAE77825 EnsemblBacteria BAE77825 http://www.ensemblgenomes.org/id/BAE77825 EnsemblBacteria BAE77825 http://www.ensemblgenomes.org/id/BAE77825 EnsemblBacteria b3468 http://www.ensemblgenomes.org/id/b3468 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 947973 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947973 HOGENOM HOG000204432 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000204432&db=HOGENOM6 IntAct P0ADI9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADI9* InterPro IPR012506 http://www.ebi.ac.uk/interpro/entry/IPR012506 KEGG_Gene ecj:JW3433 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3433 KEGG_Gene eco:b3468 http://www.genome.jp/dbget-bin/www_bget?eco:b3468 OMA AMSAFFG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AMSAFFG PSORT swissprot:YHHN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHHN_ECOLI PSORT-B swissprot:YHHN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHHN_ECOLI PSORT2 swissprot:YHHN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHHN_ECOLI Pfam PF07947 http://pfam.xfam.org/family/PF07947 Phobius swissprot:YHHN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHHN_ECOLI ProteinModelPortal P0ADI9 http://www.proteinmodelportal.org/query/uniprot/P0ADI9 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417925 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417925 RefSeq WP_000964718 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000964718 STRING 511145.b3468 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3468&targetmode=cogs UniProtKB YHHN_ECOLI http://www.uniprot.org/uniprot/YHHN_ECOLI UniProtKB-AC P0ADI9 http://www.uniprot.org/uniprot/P0ADI9 charge swissprot:YHHN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHHN_ECOLI eggNOG COG3714 http://eggnogapi.embl.de/nog_data/html/tree/COG3714 eggNOG ENOG4107FS9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107FS9 epestfind swissprot:YHHN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHHN_ECOLI garnier swissprot:YHHN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHHN_ECOLI helixturnhelix swissprot:YHHN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHHN_ECOLI hmoment swissprot:YHHN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHHN_ECOLI iep swissprot:YHHN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHHN_ECOLI inforesidue swissprot:YHHN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHHN_ECOLI octanol swissprot:YHHN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHHN_ECOLI pepcoil swissprot:YHHN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHHN_ECOLI pepdigest swissprot:YHHN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHHN_ECOLI pepinfo swissprot:YHHN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHHN_ECOLI pepnet swissprot:YHHN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHHN_ECOLI pepstats swissprot:YHHN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHHN_ECOLI pepwheel swissprot:YHHN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHHN_ECOLI pepwindow swissprot:YHHN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHHN_ECOLI sigcleave swissprot:YHHN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHHN_ECOLI ## Database ID URL or Descriptions # AltName MDTK_ECOLI Multidrug-efflux transporter # BioGrid 4260264 200 # EcoGene EG12400 mdtK # FUNCTION MDTK_ECOLI Multidrug efflux pump that probably functions as a Na(+)/drug antiporter. Confers resistance to many drugs such as fluoroquinolones (norfloxacin, ciprofloxacin, enoxacin) and tetraphenylphosphonium ion (TPP) (PubMed 9661020, PubMed 11566977). Also to deoxycholate, doxorubicin, trimethoprim, chloramphenicol, fosfomycin, ethidium bromide and benzalkonium (PubMed 11566977). Also able to export peptides; when overexpressed, allows cells deleted for multiple peptidases (pepA, pepB, pepD and pepN) to grow in the presence of dipeptides Ala-Gln or Gly-Tyr which otherwise inhibit growth (PubMed 20067529). Cells overexpressing this protein have decreased intracellular levels of Ala-Gln dipeptide, and in a system that produces the Ala-Gln dipeptide overproduction of this protein increases export of the dipeptide (PubMed 20067529). {ECO 0000269|PubMed 11566977, ECO 0000269|PubMed 12615854, ECO 0000269|PubMed 20067529, ECO 0000269|PubMed 9661020}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005215 transporter activity; IDA:EcoliWiki. # GO_function GO:0015238 drug transmembrane transporter activity; IDA:EcoliWiki. # GO_function GO:0015297 antiporter activity; IEA:UniProtKB-HAMAP. # GO_function GO:0042895 antibiotic transporter activity; IDA:EcoCyc. # GO_function GO:0071916 dipeptide transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0006814 sodium ion transport; IEA:UniProtKB-HAMAP. # GO_process GO:0015031 protein transport; IEA:UniProtKB-KW. # GO_process GO:0034614 cellular response to reactive oxygen species; IMP:EcoCyc. # GO_process GO:0035442 dipeptide transmembrane transport; IMP:EcoCyc. # GO_process GO:0042891 antibiotic transport; IDA:EcoCyc. # GO_process GO:0046677 response to antibiotic; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0055085 transmembrane transport # HAMAP MF_00400 MdtK # InterPro IPR002528 MATE_fam # InterPro IPR022913 Multidrug-R_MdtK # KEGG_Brite ko02001 Solute carrier family # Organism MDTK_ECOLI Escherichia coli (strain K12) # PATRIC 32118632 VBIEscCol129921_1736 # PIR A64924 A64924 # PIRSF PIRSF006603 DinF # Pfam PF01554 MatE; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MDTK_ECOLI Multidrug resistance protein MdtK # RefSeq WP_001174940 NZ_LN832404.1 # RefSeq YP_025307 NC_000913.3 # SIMILARITY Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION MDTK_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000305|PubMed 15919996}. # TCDB 2.A.66.1 the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily # TIGRFAMs TIGR00797 matE # eggNOG COG0534 LUCA # eggNOG ENOG4107QI1 Bacteria BLAST swissprot:MDTK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MDTK_ECOLI BioCyc ECOL316407:JW1655-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1655-MONOMER BioCyc EcoCyc:YDHE-MONOMER http://biocyc.org/getid?id=EcoCyc:YDHE-MONOMER COG COG0534 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0534 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1999.01162.x http://dx.doi.org/10.1046/j.1365-2958.1999.01162.x DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/jac/dkg126 http://dx.doi.org/10.1093/jac/dkg126 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1111/j.1574-6968.2009.01879.x http://dx.doi.org/10.1111/j.1574-6968.2009.01879.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.183.20.5803-5812.2001 http://dx.doi.org/10.1128/JB.183.20.5803-5812.2001 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U68703 http://www.ebi.ac.uk/ena/data/view/U68703 EMBL X69109 http://www.ebi.ac.uk/ena/data/view/X69109 EchoBASE EB2300 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2300 EcoGene EG12400 http://www.ecogene.org/geneInfo.php?eg_id=EG12400 EnsemblBacteria AAT48136 http://www.ensemblgenomes.org/id/AAT48136 EnsemblBacteria AAT48136 http://www.ensemblgenomes.org/id/AAT48136 EnsemblBacteria BAA15430 http://www.ensemblgenomes.org/id/BAA15430 EnsemblBacteria BAA15430 http://www.ensemblgenomes.org/id/BAA15430 EnsemblBacteria BAA15430 http://www.ensemblgenomes.org/id/BAA15430 EnsemblBacteria b1663 http://www.ensemblgenomes.org/id/b1663 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_function GO:0015238 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015238 GO_function GO:0015297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015297 GO_function GO:0042895 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042895 GO_function GO:0071916 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071916 GO_process GO:0006814 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814 GO_process GO:0015031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031 GO_process GO:0034614 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034614 GO_process GO:0035442 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035442 GO_process GO:0042891 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042891 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 945883 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945883 HAMAP MF_00400 http://hamap.expasy.org/unirule/MF_00400 HOGENOM HOG000038538 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000038538&db=HOGENOM6 InParanoid P37340 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37340 InterPro IPR002528 http://www.ebi.ac.uk/interpro/entry/IPR002528 InterPro IPR022913 http://www.ebi.ac.uk/interpro/entry/IPR022913 KEGG_Brite ko02001 http://www.genome.jp/dbget-bin/www_bget?ko02001 KEGG_Gene ecj:JW1655 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1655 KEGG_Gene eco:b1663 http://www.genome.jp/dbget-bin/www_bget?eco:b1663 KEGG_Orthology KO:K03327 http://www.genome.jp/dbget-bin/www_bget?KO:K03327 OMA SIVFMLP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SIVFMLP PSORT swissprot:MDTK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MDTK_ECOLI PSORT-B swissprot:MDTK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MDTK_ECOLI PSORT2 swissprot:MDTK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MDTK_ECOLI Pfam PF01554 http://pfam.xfam.org/family/PF01554 Phobius swissprot:MDTK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MDTK_ECOLI PhylomeDB P37340 http://phylomedb.org/?seqid=P37340 ProteinModelPortal P37340 http://www.proteinmodelportal.org/query/uniprot/P37340 PubMed 11566977 http://www.ncbi.nlm.nih.gov/pubmed/11566977 PubMed 12615854 http://www.ncbi.nlm.nih.gov/pubmed/12615854 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20067529 http://www.ncbi.nlm.nih.gov/pubmed/20067529 PubMed 9023191 http://www.ncbi.nlm.nih.gov/pubmed/9023191 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9661020 http://www.ncbi.nlm.nih.gov/pubmed/9661020 PubMed 9987140 http://www.ncbi.nlm.nih.gov/pubmed/9987140 RefSeq WP_001174940 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001174940 RefSeq YP_025307 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_025307 STRING 511145.b1663 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1663&targetmode=cogs STRING COG0534 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0534&targetmode=cogs TCDB 2.A.66.1 http://www.tcdb.org/search/result.php?tc=2.A.66.1 TIGRFAMs TIGR00797 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00797 UniProtKB MDTK_ECOLI http://www.uniprot.org/uniprot/MDTK_ECOLI UniProtKB-AC P37340 http://www.uniprot.org/uniprot/P37340 charge swissprot:MDTK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MDTK_ECOLI eggNOG COG0534 http://eggnogapi.embl.de/nog_data/html/tree/COG0534 eggNOG ENOG4107QI1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QI1 epestfind swissprot:MDTK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MDTK_ECOLI garnier swissprot:MDTK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MDTK_ECOLI helixturnhelix swissprot:MDTK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MDTK_ECOLI hmoment swissprot:MDTK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MDTK_ECOLI iep swissprot:MDTK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MDTK_ECOLI inforesidue swissprot:MDTK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MDTK_ECOLI octanol swissprot:MDTK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MDTK_ECOLI pepcoil swissprot:MDTK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MDTK_ECOLI pepdigest swissprot:MDTK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MDTK_ECOLI pepinfo swissprot:MDTK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MDTK_ECOLI pepnet swissprot:MDTK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MDTK_ECOLI pepstats swissprot:MDTK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MDTK_ECOLI pepwheel swissprot:MDTK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MDTK_ECOLI pepwindow swissprot:MDTK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MDTK_ECOLI sigcleave swissprot:MDTK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MDTK_ECOLI ## Database ID URL or Descriptions # BioGrid 4261394 17 # DISRUPTION PHENOTYPE HOFQ_ECOLI Mutants show a stationary-phase competition defect during coculture with wild-type cells and an inability to utilize extracellular DNA as the sole source of carbon or energy. {ECO 0000269|PubMed 11591672, ECO 0000269|PubMed 16707682}. # EcoGene EG12113 hofQ # FUNCTION HOFQ_ECOLI Required for the use of extracellular DNA as a nutrient. Could be the porin responsible for transport of DNA across the outer membrane. {ECO 0000269|PubMed 16707682}. # GO_component GO:0009279 cell outer membrane; IEA:UniProtKB-SubCell. # GO_function GO:0003677 DNA binding; IMP:EcoliWiki. # GO_function GO:0008565 protein transporter activity; IEA:InterPro. # GO_process GO:0006810 transport; IMP:EcoliWiki. # GO_process GO:0009297 pilus assembly; IEA:InterPro. # GO_process GO:0009306 protein secretion; IEA:InterPro. # GO_process GO:0015976 carbon utilization; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0008565 protein transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # GOslim_process GO:0022607 cellular component assembly # IntAct P34749 6 # InterPro IPR001775 GspD/PilQ # InterPro IPR004845 T2SS_GspD_CS # InterPro IPR004846 T2SS/T3SS # InterPro IPR005644 NolW-like # InterPro IPR011662 Secretin/TonB_short_N # InterPro IPR013355 Pilus_4_PilQ # KEGG_Brite ko02044 Secretion system # Organism HOFQ_ECOLI Escherichia coli (strain K12) # PATRIC 32122214 VBIEscCol129921_3484 # PIR B65134 B65134 # PRINTS PR00811 BCTERIALGSPD # PROSITE PS00875 T2SP_D # Pfam PF00263 Secretin # Pfam PF03958 Secretin_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HOFQ_ECOLI Putative DNA transport protein HofQ # RefSeq NP_417850 NC_000913.3 # SIMILARITY Belongs to the GSP D family. {ECO 0000305}. # SMART SM00965 STN # SUBCELLULAR LOCATION HOFQ_ECOLI Cell outer membrane {ECO 0000305}. # TIGRFAMs TIGR02515 IV_pilus_PilQ # eggNOG COG4796 LUCA # eggNOG ENOG4105E4G Bacteria BLAST swissprot:HOFQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HOFQ_ECOLI BioCyc ECOL316407:JW3354-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3354-MONOMER BioCyc EcoCyc:EG12113-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12113-MONOMER COG COG1450 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1450 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1993.tb01744.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb01744.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01974-05 http://dx.doi.org/10.1128/JB.01974-05 DOI 10.1128/JB.183.21.6288-6293.2001 http://dx.doi.org/10.1128/JB.183.21.6288-6293.2001 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL Z19601 http://www.ebi.ac.uk/ena/data/view/Z19601 EchoBASE EB2036 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2036 EcoGene EG12113 http://www.ecogene.org/geneInfo.php?eg_id=EG12113 EnsemblBacteria AAC76416 http://www.ensemblgenomes.org/id/AAC76416 EnsemblBacteria AAC76416 http://www.ensemblgenomes.org/id/AAC76416 EnsemblBacteria BAE77900 http://www.ensemblgenomes.org/id/BAE77900 EnsemblBacteria BAE77900 http://www.ensemblgenomes.org/id/BAE77900 EnsemblBacteria BAE77900 http://www.ensemblgenomes.org/id/BAE77900 EnsemblBacteria b3391 http://www.ensemblgenomes.org/id/b3391 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GO_process GO:0009297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009297 GO_process GO:0009306 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009306 GO_process GO:0015976 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015976 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GeneID 947901 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947901 HOGENOM HOG000255072 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000255072&db=HOGENOM6 InParanoid P34749 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P34749 IntAct P34749 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P34749* InterPro IPR001775 http://www.ebi.ac.uk/interpro/entry/IPR001775 InterPro IPR004845 http://www.ebi.ac.uk/interpro/entry/IPR004845 InterPro IPR004846 http://www.ebi.ac.uk/interpro/entry/IPR004846 InterPro IPR005644 http://www.ebi.ac.uk/interpro/entry/IPR005644 InterPro IPR011662 http://www.ebi.ac.uk/interpro/entry/IPR011662 InterPro IPR013355 http://www.ebi.ac.uk/interpro/entry/IPR013355 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW3354 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3354 KEGG_Gene eco:b3391 http://www.genome.jp/dbget-bin/www_bget?eco:b3391 KEGG_Orthology KO:K02507 http://www.genome.jp/dbget-bin/www_bget?KO:K02507 OMA YQVSSGA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YQVSSGA PRINTS PR00811 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00811 PROSITE PS00875 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00875 PSORT swissprot:HOFQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HOFQ_ECOLI PSORT-B swissprot:HOFQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HOFQ_ECOLI PSORT2 swissprot:HOFQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HOFQ_ECOLI Pfam PF00263 http://pfam.xfam.org/family/PF00263 Pfam PF03958 http://pfam.xfam.org/family/PF03958 Phobius swissprot:HOFQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HOFQ_ECOLI PhylomeDB P34749 http://phylomedb.org/?seqid=P34749 ProteinModelPortal P34749 http://www.proteinmodelportal.org/query/uniprot/P34749 PubMed 11591672 http://www.ncbi.nlm.nih.gov/pubmed/11591672 PubMed 1309529 http://www.ncbi.nlm.nih.gov/pubmed/1309529 PubMed 16707682 http://www.ncbi.nlm.nih.gov/pubmed/16707682 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7901733 http://www.ncbi.nlm.nih.gov/pubmed/7901733 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417850 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417850 SMART SM00965 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00965 SMR P34749 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P34749 STRING 511145.b3391 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3391&targetmode=cogs STRING COG1450 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1450&targetmode=cogs TIGRFAMs TIGR02515 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02515 UniProtKB HOFQ_ECOLI http://www.uniprot.org/uniprot/HOFQ_ECOLI UniProtKB-AC P34749 http://www.uniprot.org/uniprot/P34749 charge swissprot:HOFQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HOFQ_ECOLI eggNOG COG4796 http://eggnogapi.embl.de/nog_data/html/tree/COG4796 eggNOG ENOG4105E4G http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E4G epestfind swissprot:HOFQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HOFQ_ECOLI garnier swissprot:HOFQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HOFQ_ECOLI helixturnhelix swissprot:HOFQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HOFQ_ECOLI hmoment swissprot:HOFQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HOFQ_ECOLI iep swissprot:HOFQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HOFQ_ECOLI inforesidue swissprot:HOFQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HOFQ_ECOLI octanol swissprot:HOFQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HOFQ_ECOLI pepcoil swissprot:HOFQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HOFQ_ECOLI pepdigest swissprot:HOFQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HOFQ_ECOLI pepinfo swissprot:HOFQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HOFQ_ECOLI pepnet swissprot:HOFQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HOFQ_ECOLI pepstats swissprot:HOFQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HOFQ_ECOLI pepwheel swissprot:HOFQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HOFQ_ECOLI pepwindow swissprot:HOFQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HOFQ_ECOLI sigcleave swissprot:HOFQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HOFQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4261816 142 # EcoGene EG11056 umuC # FUNCTION UMUC_ECOLI Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template. # GO_component GO:0016021 integral component of membrane; IDA:EcoliWiki. # GO_function GO:0003684 damaged DNA binding; IEA:InterPro. # GO_process GO:0000012 single strand break repair; IMP:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0009432 SOS response; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # Gene3D 3.30.1490.100 -; 1. # INDUCTION Induced 1.5-fold by hydroxyurea. {ECO:0000269|PubMed 20005847}. # IntAct P04152 9 # InterPro IPR001126 UmuC # InterPro IPR017961 DNA_pol_Y-fam_little_finger # InterPro IPR024728 PolY_HhH_motif # InterPro IPR025188 DUF4113 # KEGG_Brite ko03400 DNA repair and recombination proteins # Organism UMUC_ECOLI Escherichia coli (strain K12) # PATRIC 32117614 VBIEscCol129921_1229 # PIR E64864 ZWECC # PROSITE PS50173 UMUC # Pfam PF00817 IMS # Pfam PF11798 IMS_HHH # Pfam PF11799 IMS_C # Pfam PF13438 DUF4113 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UMUC_ECOLI Protein UmuC # RefSeq NP_415702 NC_000913.3 # RefSeq WP_000457616 NZ_LN832404.1 # SIMILARITY Belongs to the DNA polymerase type-Y family. {ECO 0000305}. # SIMILARITY Contains 1 umuC domain. {ECO:0000255|PROSITE- ProRule PRU00216}. # SUPFAM SSF100879 SSF100879 # eggNOG COG0389 LUCA # eggNOG ENOG4105CQ3 Bacteria BLAST swissprot:UMUC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UMUC_ECOLI BioCyc ECOL316407:JW1173-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1173-MONOMER BioCyc EcoCyc:EG11056-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11056-MONOMER BioCyc MetaCyc:EG11056-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11056-MONOMER COG COG0389 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0389 DIP DIP-11090N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11090N DOI 10.1007/BF00265442 http://dx.doi.org/10.1007/BF00265442 DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.82.13.4331 http://dx.doi.org/10.1073/pnas.82.13.4331 DOI 10.1073/pnas.82.13.4336 http://dx.doi.org/10.1073/pnas.82.13.4336 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M10107 http://www.ebi.ac.uk/ena/data/view/M10107 EMBL M13387 http://www.ebi.ac.uk/ena/data/view/M13387 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1049 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1049 EcoGene EG11056 http://www.ecogene.org/geneInfo.php?eg_id=EG11056 EnsemblBacteria AAC74268 http://www.ensemblgenomes.org/id/AAC74268 EnsemblBacteria AAC74268 http://www.ensemblgenomes.org/id/AAC74268 EnsemblBacteria BAA36031 http://www.ensemblgenomes.org/id/BAA36031 EnsemblBacteria BAA36031 http://www.ensemblgenomes.org/id/BAA36031 EnsemblBacteria BAA36031 http://www.ensemblgenomes.org/id/BAA36031 EnsemblBacteria b1184 http://www.ensemblgenomes.org/id/b1184 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0003684 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003684 GO_process GO:0000012 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000012 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0009432 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009432 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.30.1490.100 http://www.cathdb.info/version/latest/superfamily/3.30.1490.100 GeneID 946359 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946359 HOGENOM HOG000252172 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000252172&db=HOGENOM6 InParanoid P04152 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P04152 IntAct P04152 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P04152* InterPro IPR001126 http://www.ebi.ac.uk/interpro/entry/IPR001126 InterPro IPR017961 http://www.ebi.ac.uk/interpro/entry/IPR017961 InterPro IPR024728 http://www.ebi.ac.uk/interpro/entry/IPR024728 InterPro IPR025188 http://www.ebi.ac.uk/interpro/entry/IPR025188 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW1173 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1173 KEGG_Gene eco:b1184 http://www.genome.jp/dbget-bin/www_bget?eco:b1184 KEGG_Orthology KO:K03502 http://www.genome.jp/dbget-bin/www_bget?KO:K03502 MINT MINT-1516814 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1516814 OMA QETCVSR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QETCVSR PROSITE PS50173 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50173 PSORT swissprot:UMUC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UMUC_ECOLI PSORT-B swissprot:UMUC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UMUC_ECOLI PSORT2 swissprot:UMUC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UMUC_ECOLI Pfam PF00817 http://pfam.xfam.org/family/PF00817 Pfam PF11798 http://pfam.xfam.org/family/PF11798 Pfam PF11799 http://pfam.xfam.org/family/PF11799 Pfam PF13438 http://pfam.xfam.org/family/PF13438 Phobius swissprot:UMUC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UMUC_ECOLI PhylomeDB P04152 http://phylomedb.org/?seqid=P04152 ProteinModelPortal P04152 http://www.proteinmodelportal.org/query/uniprot/P04152 PubMed 1320188 http://www.ncbi.nlm.nih.gov/pubmed/1320188 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 2989816 http://www.ncbi.nlm.nih.gov/pubmed/2989816 PubMed 2989817 http://www.ncbi.nlm.nih.gov/pubmed/2989817 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415702 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415702 RefSeq WP_000457616 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000457616 SMR P04152 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P04152 STRING 511145.b1184 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1184&targetmode=cogs STRING COG0389 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0389&targetmode=cogs SUPFAM SSF100879 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF100879 UniProtKB UMUC_ECOLI http://www.uniprot.org/uniprot/UMUC_ECOLI UniProtKB-AC P04152 http://www.uniprot.org/uniprot/P04152 charge swissprot:UMUC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UMUC_ECOLI eggNOG COG0389 http://eggnogapi.embl.de/nog_data/html/tree/COG0389 eggNOG ENOG4105CQ3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CQ3 epestfind swissprot:UMUC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UMUC_ECOLI garnier swissprot:UMUC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UMUC_ECOLI helixturnhelix swissprot:UMUC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UMUC_ECOLI hmoment swissprot:UMUC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UMUC_ECOLI iep swissprot:UMUC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UMUC_ECOLI inforesidue swissprot:UMUC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UMUC_ECOLI octanol swissprot:UMUC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UMUC_ECOLI pepcoil swissprot:UMUC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UMUC_ECOLI pepdigest swissprot:UMUC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UMUC_ECOLI pepinfo swissprot:UMUC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UMUC_ECOLI pepnet swissprot:UMUC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UMUC_ECOLI pepstats swissprot:UMUC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UMUC_ECOLI pepwheel swissprot:UMUC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UMUC_ECOLI pepwindow swissprot:UMUC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UMUC_ECOLI sigcleave swissprot:UMUC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UMUC_ECOLI ## Database ID URL or Descriptions # BioGrid 4262661 4 # CDD cd06261 TM_PBP2 # EcoGene EG10556 malG # FUNCTION MALG_ECOLI Part of the binding-protein-dependent transport system for maltose; probably responsible for the translocation of the substrate across the membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IDA:EcoCyc. # GO_component GO:0055052 ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing; IBA:GO_Central. # GO_component GO:1990060 maltose transport complex; IDA:EcoCyc. # GO_function GO:0015423 maltose-transporting ATPase activity; IDA:EcoCyc. # GO_process GO:0015768 maltose transport; IDA:EcoCyc. # GO_process GO:0042956 maltodextrin transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # Gene3D 1.10.3720.10 -; 1. # IntAct P68183 4 # InterPro IPR000515 MetI-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00194 Maltose/maltodextrin transport system # KEGG_Brite ko02000 M00197 Putative fructooligosaccharide transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # MISCELLANEOUS MALG_ECOLI When MalF EAA loop mutations are made concomitantly with MalG EAA loop mutations, a complete loss of transport and complex formation is observed. This suggests that the MalF-MalG interaction may be important for the proper assembly and also for the correct function of the transporter. # Organism MALG_ECOLI Escherichia coli (strain K12) # PATRIC 32123597 VBIEscCol129921_4147 # PDB 2R6G X-ray; 2.80 A; G=1-296 # PDB 3FH6 X-ray; 4.50 A; G/I=1-296 # PDB 3PUV X-ray; 2.40 A; G=1-296 # PDB 3PUW X-ray; 2.30 A; G=1-296 # PDB 3PUX X-ray; 2.30 A; G=1-296 # PDB 3PUY X-ray; 3.10 A; G=1-296 # PDB 3PUZ X-ray; 2.90 A; G=1-296 # PDB 3PV0 X-ray; 3.10 A; G=1-296 # PDB 3RLF X-ray; 2.20 A; G=1-296 # PDB 4JBW X-ray; 3.91 A; G/I=1-296 # PDB 4KI0 X-ray; 2.38 A; G=1-296 # PIR A24361 MMECMG # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MALG_ECOLI Maltose transport system permease protein MalG # RefSeq NP_418456 NC_000913.3 # RefSeq WP_001252058 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION MALG_ECOLI Cell inner membrane {ECO 0000269|PubMed 18456666, ECO 0000269|PubMed 2233678}; Multi- pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00441, ECO 0000269|PubMed 18456666, ECO 0000269|PubMed 2233678}. # SUBUNIT MALG_ECOLI The complex is composed of two ATP-binding proteins (MalK), two transmembrane proteins (MalG and MalF) and a solute- binding protein (MalE). Protein stability and stable complex formation require YidC. {ECO 0000269|PubMed 10809785, ECO 0000269|PubMed 18456666}. # SUPFAM SSF161098 SSF161098 # TCDB 3.A.1.1 the atp-binding cassette (abc) superfamily # eggNOG COG3833 LUCA # eggNOG ENOG4105EG2 Bacteria BLAST swissprot:MALG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MALG_ECOLI BioCyc ECOL316407:JW3992-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3992-MONOMER BioCyc EcoCyc:MALG-MONOMER http://biocyc.org/getid?id=EcoCyc:MALG-MONOMER BioCyc MetaCyc:MALG-MONOMER http://biocyc.org/getid?id=MetaCyc:MALG-MONOMER COG COG3833 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3833 DIP DIP-59709N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-59709N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.275.20.15526 http://dx.doi.org/10.1074/jbc.275.20.15526 DOI 10.1074/jbc.M801481200 http://dx.doi.org/10.1074/jbc.M801481200 DOI 10.1093/emboj/16.11.3066 http://dx.doi.org/10.1093/emboj/16.11.3066 DOI 10.1093/nar/16.9.4097 http://dx.doi.org/10.1093/nar/16.9.4097 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1111/j.1365-2958.1993.tb01094.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb01094.x DOI 10.1111/j.1365-2958.1993.tb01095.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb01095.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J02812 http://www.ebi.ac.uk/ena/data/view/J02812 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X02871 http://www.ebi.ac.uk/ena/data/view/X02871 EMBL X06663 http://www.ebi.ac.uk/ena/data/view/X06663 EchoBASE EB0551 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0551 EcoGene EG10556 http://www.ecogene.org/geneInfo.php?eg_id=EG10556 EnsemblBacteria AAC77002 http://www.ensemblgenomes.org/id/AAC77002 EnsemblBacteria AAC77002 http://www.ensemblgenomes.org/id/AAC77002 EnsemblBacteria BAE78034 http://www.ensemblgenomes.org/id/BAE78034 EnsemblBacteria BAE78034 http://www.ensemblgenomes.org/id/BAE78034 EnsemblBacteria BAE78034 http://www.ensemblgenomes.org/id/BAE78034 EnsemblBacteria b4032 http://www.ensemblgenomes.org/id/b4032 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_component GO:0055052 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055052 GO_component GO:1990060 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990060 GO_function GO:0015423 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015423 GO_process GO:0015768 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015768 GO_process GO:0042956 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042956 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 948530 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948530 HOGENOM HOG000220526 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220526&db=HOGENOM6 InParanoid P68183 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P68183 IntAct P68183 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P68183* InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3992 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3992 KEGG_Gene eco:b4032 http://www.genome.jp/dbget-bin/www_bget?eco:b4032 KEGG_Orthology KO:K10110 http://www.genome.jp/dbget-bin/www_bget?KO:K10110 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA GIFRYII http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GIFRYII PDB 2R6G http://www.ebi.ac.uk/pdbe-srv/view/entry/2R6G PDB 3FH6 http://www.ebi.ac.uk/pdbe-srv/view/entry/3FH6 PDB 3PUV http://www.ebi.ac.uk/pdbe-srv/view/entry/3PUV PDB 3PUW http://www.ebi.ac.uk/pdbe-srv/view/entry/3PUW PDB 3PUX http://www.ebi.ac.uk/pdbe-srv/view/entry/3PUX PDB 3PUY http://www.ebi.ac.uk/pdbe-srv/view/entry/3PUY PDB 3PUZ http://www.ebi.ac.uk/pdbe-srv/view/entry/3PUZ PDB 3PV0 http://www.ebi.ac.uk/pdbe-srv/view/entry/3PV0 PDB 3RLF http://www.ebi.ac.uk/pdbe-srv/view/entry/3RLF PDB 4JBW http://www.ebi.ac.uk/pdbe-srv/view/entry/4JBW PDB 4KI0 http://www.ebi.ac.uk/pdbe-srv/view/entry/4KI0 PDBsum 2R6G http://www.ebi.ac.uk/pdbsum/2R6G PDBsum 3FH6 http://www.ebi.ac.uk/pdbsum/3FH6 PDBsum 3PUV http://www.ebi.ac.uk/pdbsum/3PUV PDBsum 3PUW http://www.ebi.ac.uk/pdbsum/3PUW PDBsum 3PUX http://www.ebi.ac.uk/pdbsum/3PUX PDBsum 3PUY http://www.ebi.ac.uk/pdbsum/3PUY PDBsum 3PUZ http://www.ebi.ac.uk/pdbsum/3PUZ PDBsum 3PV0 http://www.ebi.ac.uk/pdbsum/3PV0 PDBsum 3RLF http://www.ebi.ac.uk/pdbsum/3RLF PDBsum 4JBW http://www.ebi.ac.uk/pdbsum/4JBW PDBsum 4KI0 http://www.ebi.ac.uk/pdbsum/4KI0 PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:MALG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MALG_ECOLI PSORT-B swissprot:MALG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MALG_ECOLI PSORT2 swissprot:MALG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MALG_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Phobius swissprot:MALG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MALG_ECOLI PhylomeDB P68183 http://phylomedb.org/?seqid=P68183 ProteinModelPortal P68183 http://www.proteinmodelportal.org/query/uniprot/P68183 PubMed 10809785 http://www.ncbi.nlm.nih.gov/pubmed/10809785 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18456666 http://www.ncbi.nlm.nih.gov/pubmed/18456666 PubMed 2233678 http://www.ncbi.nlm.nih.gov/pubmed/2233678 PubMed 2820984 http://www.ncbi.nlm.nih.gov/pubmed/2820984 PubMed 2836810 http://www.ncbi.nlm.nih.gov/pubmed/2836810 PubMed 3000770 http://www.ncbi.nlm.nih.gov/pubmed/3000770 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 8437518 http://www.ncbi.nlm.nih.gov/pubmed/8437518 PubMed 8437519 http://www.ncbi.nlm.nih.gov/pubmed/8437519 PubMed 9214624 http://www.ncbi.nlm.nih.gov/pubmed/9214624 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9529892 http://www.ncbi.nlm.nih.gov/pubmed/9529892 RefSeq NP_418456 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418456 RefSeq WP_001252058 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001252058 SMR P68183 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P68183 STRING 511145.b4032 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4032&targetmode=cogs STRING COG3833 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3833&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.1 http://www.tcdb.org/search/result.php?tc=3.A.1.1 UniProtKB MALG_ECOLI http://www.uniprot.org/uniprot/MALG_ECOLI UniProtKB-AC P68183 http://www.uniprot.org/uniprot/P68183 charge swissprot:MALG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MALG_ECOLI eggNOG COG3833 http://eggnogapi.embl.de/nog_data/html/tree/COG3833 eggNOG ENOG4105EG2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EG2 epestfind swissprot:MALG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MALG_ECOLI garnier swissprot:MALG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MALG_ECOLI helixturnhelix swissprot:MALG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MALG_ECOLI hmoment swissprot:MALG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MALG_ECOLI iep swissprot:MALG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MALG_ECOLI inforesidue swissprot:MALG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MALG_ECOLI octanol swissprot:MALG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MALG_ECOLI pepcoil swissprot:MALG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MALG_ECOLI pepdigest swissprot:MALG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MALG_ECOLI pepinfo swissprot:MALG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MALG_ECOLI pepnet swissprot:MALG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MALG_ECOLI pepstats swissprot:MALG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MALG_ECOLI pepwheel swissprot:MALG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MALG_ECOLI pepwindow swissprot:MALG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MALG_ECOLI sigcleave swissprot:MALG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MALG_ECOLI ## Database ID URL or Descriptions # BioGrid 4262139 6 # EcoGene EG10734 pstS # FUNCTION PSTS_ECOLI Part of the ABC transporter complex PstSACB involved in phosphate import. # GO_component GO:0005886 plasma membrane; IBA:GO_Central. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IEA:InterPro. # GO_function GO:0015415 ATPase-coupled phosphate ion transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0042301 phosphate ion binding; IBA:GO_Central. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0016036 cellular response to phosphate starvation; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # INDUCTION PSTS_ECOLI By phosphate deprivation. Positively regulated by PhoB and negatively regulated by PhoR. # IntAct P0AG82 2 # InterPro IPR005673 ABC_phos-bd_PstS # InterPro IPR024370 PBP_domain # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00222 Phosphate transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # KEGG_Pathway ko02020 Two-component system # KEGG_Pathway ko05152 Tuberculosis # Organism PSTS_ECOLI Escherichia coli (strain K12) # PATRIC 32122953 VBIEscCol129921_3852 # PDB 1A40 X-ray; 1.70 A; A=26-346 # PDB 1A54 X-ray; 1.60 A; A=26-346 # PDB 1A55 X-ray; 2.40 A; A=26-346 # PDB 1IXG X-ray; 1.05 A; A=26-346 # PDB 1IXH X-ray; 0.98 A; A=26-346 # PDB 1IXI X-ray; 1.89 A; A=26-346 # PDB 1OIB X-ray; 2.40 A; A/B=26-346 # PDB 1PBP X-ray; 1.90 A; A=26-346 # PDB 1QUI X-ray; 1.90 A; A=26-346 # PDB 1QUJ X-ray; 1.90 A; A=26-346 # PDB 1QUK X-ray; 1.70 A; A=26-346 # PDB 1QUL X-ray; 1.70 A; A=26-346 # PDB 2ABH X-ray; 1.70 A; A=26-346 # PIR A30277 BYECPR # PIRSF PIRSF002756 PstS # Pfam PF12849 PBP_like_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PSTS_ECOLI Phosphate-binding protein PstS # RefSeq NP_418184 NC_000913.3 # RefSeq WP_000867146 NZ_LN832404.1 # SIMILARITY Belongs to the PstS family. {ECO 0000305}. # SUBCELLULAR LOCATION PSTS_ECOLI Periplasm. # SUBUNIT The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute- binding protein (PstS). {ECO 0000305}. # TCDB 3.A.1.7 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR00975 3a0107s03 # eggNOG COG0226 LUCA # eggNOG ENOG4107QMV Bacteria BLAST swissprot:PSTS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PSTS_ECOLI BioCyc ECOL316407:JW3706-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3706-MONOMER BioCyc EcoCyc:PSTS-MONOMER http://biocyc.org/getid?id=EcoCyc:PSTS-MONOMER BioCyc MetaCyc:PSTS-MONOMER http://biocyc.org/getid?id=MetaCyc:PSTS-MONOMER COG COG0226 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0226 DIP DIP-48241N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48241N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1021/bi980428z http://dx.doi.org/10.1021/bi980428z DOI 10.1038/347402a0 http://dx.doi.org/10.1038/347402a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb0797-519 http://dx.doi.org/10.1038/nsb0797-519 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K01992 http://www.ebi.ac.uk/ena/data/view/K01992 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0727 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0727 EcoGene EG10734 http://www.ecogene.org/geneInfo.php?eg_id=EG10734 EnsemblBacteria AAC76751 http://www.ensemblgenomes.org/id/AAC76751 EnsemblBacteria AAC76751 http://www.ensemblgenomes.org/id/AAC76751 EnsemblBacteria BAE77560 http://www.ensemblgenomes.org/id/BAE77560 EnsemblBacteria BAE77560 http://www.ensemblgenomes.org/id/BAE77560 EnsemblBacteria BAE77560 http://www.ensemblgenomes.org/id/BAE77560 EnsemblBacteria b3728 http://www.ensemblgenomes.org/id/b3728 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0015415 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015415 GO_function GO:0042301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042301 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0016036 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016036 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 948237 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948237 HOGENOM HOG000236794 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000236794&db=HOGENOM6 InParanoid P0AG82 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AG82 IntAct P0AG82 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AG82* InterPro IPR005673 http://www.ebi.ac.uk/interpro/entry/IPR005673 InterPro IPR024370 http://www.ebi.ac.uk/interpro/entry/IPR024370 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3706 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3706 KEGG_Gene eco:b3728 http://www.genome.jp/dbget-bin/www_bget?eco:b3728 KEGG_Orthology KO:K02040 http://www.genome.jp/dbget-bin/www_bget?KO:K02040 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 KEGG_Pathway ko05152 http://www.genome.jp/kegg-bin/show_pathway?ko05152 MINT MINT-1224444 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1224444 OMA GEIEYWD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GEIEYWD PDB 1A40 http://www.ebi.ac.uk/pdbe-srv/view/entry/1A40 PDB 1A54 http://www.ebi.ac.uk/pdbe-srv/view/entry/1A54 PDB 1A55 http://www.ebi.ac.uk/pdbe-srv/view/entry/1A55 PDB 1IXG http://www.ebi.ac.uk/pdbe-srv/view/entry/1IXG PDB 1IXH http://www.ebi.ac.uk/pdbe-srv/view/entry/1IXH PDB 1IXI http://www.ebi.ac.uk/pdbe-srv/view/entry/1IXI PDB 1OIB http://www.ebi.ac.uk/pdbe-srv/view/entry/1OIB PDB 1PBP http://www.ebi.ac.uk/pdbe-srv/view/entry/1PBP PDB 1QUI http://www.ebi.ac.uk/pdbe-srv/view/entry/1QUI PDB 1QUJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1QUJ PDB 1QUK http://www.ebi.ac.uk/pdbe-srv/view/entry/1QUK PDB 1QUL http://www.ebi.ac.uk/pdbe-srv/view/entry/1QUL PDB 2ABH http://www.ebi.ac.uk/pdbe-srv/view/entry/2ABH PDBsum 1A40 http://www.ebi.ac.uk/pdbsum/1A40 PDBsum 1A54 http://www.ebi.ac.uk/pdbsum/1A54 PDBsum 1A55 http://www.ebi.ac.uk/pdbsum/1A55 PDBsum 1IXG http://www.ebi.ac.uk/pdbsum/1IXG PDBsum 1IXH http://www.ebi.ac.uk/pdbsum/1IXH PDBsum 1IXI http://www.ebi.ac.uk/pdbsum/1IXI PDBsum 1OIB http://www.ebi.ac.uk/pdbsum/1OIB PDBsum 1PBP http://www.ebi.ac.uk/pdbsum/1PBP PDBsum 1QUI http://www.ebi.ac.uk/pdbsum/1QUI PDBsum 1QUJ http://www.ebi.ac.uk/pdbsum/1QUJ PDBsum 1QUK http://www.ebi.ac.uk/pdbsum/1QUK PDBsum 1QUL http://www.ebi.ac.uk/pdbsum/1QUL PDBsum 2ABH http://www.ebi.ac.uk/pdbsum/2ABH PSORT swissprot:PSTS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PSTS_ECOLI PSORT-B swissprot:PSTS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PSTS_ECOLI PSORT2 swissprot:PSTS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PSTS_ECOLI Pfam PF12849 http://pfam.xfam.org/family/PF12849 Phobius swissprot:PSTS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PSTS_ECOLI PhylomeDB P0AG82 http://phylomedb.org/?seqid=P0AG82 ProteinModelPortal P0AG82 http://www.proteinmodelportal.org/query/uniprot/P0AG82 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2215649 http://www.ncbi.nlm.nih.gov/pubmed/2215649 PubMed 6321434 http://www.ncbi.nlm.nih.gov/pubmed/6321434 PubMed 6365894 http://www.ncbi.nlm.nih.gov/pubmed/6365894 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9228942 http://www.ncbi.nlm.nih.gov/pubmed/9228942 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9671506 http://www.ncbi.nlm.nih.gov/pubmed/9671506 RefSeq NP_418184 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418184 RefSeq WP_000867146 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000867146 SMR P0AG82 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AG82 STRING 511145.b3728 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3728&targetmode=cogs STRING COG0226 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0226&targetmode=cogs SWISS-2DPAGE P0AG82 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AG82 TCDB 3.A.1.7 http://www.tcdb.org/search/result.php?tc=3.A.1.7 TIGRFAMs TIGR00975 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00975 UniProtKB PSTS_ECOLI http://www.uniprot.org/uniprot/PSTS_ECOLI UniProtKB-AC P0AG82 http://www.uniprot.org/uniprot/P0AG82 charge swissprot:PSTS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PSTS_ECOLI eggNOG COG0226 http://eggnogapi.embl.de/nog_data/html/tree/COG0226 eggNOG ENOG4107QMV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QMV epestfind swissprot:PSTS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PSTS_ECOLI garnier swissprot:PSTS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PSTS_ECOLI helixturnhelix swissprot:PSTS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PSTS_ECOLI hmoment swissprot:PSTS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PSTS_ECOLI iep swissprot:PSTS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PSTS_ECOLI inforesidue swissprot:PSTS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PSTS_ECOLI octanol swissprot:PSTS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PSTS_ECOLI pepcoil swissprot:PSTS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PSTS_ECOLI pepdigest swissprot:PSTS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PSTS_ECOLI pepinfo swissprot:PSTS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PSTS_ECOLI pepnet swissprot:PSTS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PSTS_ECOLI pepstats swissprot:PSTS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PSTS_ECOLI pepwheel swissprot:PSTS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PSTS_ECOLI pepwindow swissprot:PSTS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PSTS_ECOLI sigcleave swissprot:PSTS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PSTS_ECOLI ## Database ID URL or Descriptions # BioGrid 4262159 13 # DISRUPTION PHENOTYPE Cells lacking this gene are only able to grow after a 2-day lag period on D-malate as sole carbon source. {ECO:0000269|PubMed 17088549}. # EcoGene EG20044 dctA # FUNCTION DCTA_ECOLI Responsible for the aerobic transport of the dicarboxylates fumarate, L- and D-malate and to a lesser extent succinate, from the periplasm across the inner membrane. {ECO 0000269|PubMed 17088549}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IDA:EcoCyc. # GO_function DCTA_ECOLI GO 0015366 malate proton symporter activity; IDA EcoCyc. # GO_function GO:0015138 fumarate transmembrane transporter activity; IMP:EcoCyc. # GO_function GO:0015141 succinate transmembrane transporter activity; IMP:EcoCyc. # GO_function GO:0015183 L-aspartate transmembrane transporter activity; IDA:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0015741 fumarate transport; IDA:EcoliWiki. # GO_process GO:0070778 L-aspartate transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0006950 response to stress # Gene3D 1.10.3860.10 -; 1. # HAMAP MF_01300 C4_dicarb_transport # INDUCTION Subject to CRP-mediated catabolite repression. Repressed in the absence of oxygen, induced in the stationary phase and approximately 2-fold by citrate and C4-dicarboxylates. {ECO:0000269|PubMed 17088549}. # InterPro IPR001991 Na-dicarboxylate_symporter # InterPro IPR018107 Na-dicarboxylate_symporter_CS # InterPro IPR023954 C4_dicarb_transport # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko02020 Two-component system # Organism DCTA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11958 PTHR11958 # PATRIC 32122520 VBIEscCol129921_3638 # PIR S47749 S47749 # PRINTS PR00173 EDTRNSPORT # PROSITE PS00713 NA_DICARBOXYL_SYMP_1 # PROSITE PS00714 NA_DICARBOXYL_SYMP_2 # Pfam PF00375 SDF # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DCTA_ECOLI Aerobic C4-dicarboxylate transport protein # RefSeq NP_417985 NC_000913.3 # RefSeq WP_000858214 NZ_LN832404.1 # SIMILARITY Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. {ECO 0000305}. # SUBCELLULAR LOCATION DCTA_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # SUPFAM SSF118215 SSF118215 # TCDB 2.A.23.1:the dicarboxylate/amino acid cation (na(+) or h(+)) symporter (daacs) family # eggNOG COG1301 LUCA # eggNOG ENOG4105CK2 Bacteria BLAST swissprot:DCTA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DCTA_ECOLI BioCyc ECOL316407:JW3496-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3496-MONOMER BioCyc EcoCyc:DCTA-MONOMER http://biocyc.org/getid?id=EcoCyc:DCTA-MONOMER BioCyc MetaCyc:DCTA-MONOMER http://biocyc.org/getid?id=MetaCyc:DCTA-MONOMER COG COG1301 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1301 DIP DIP-47958N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47958N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0603364103 http://dx.doi.org/10.1073/pnas.0603364103 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4140 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4140 EcoGene EG20044 http://www.ecogene.org/geneInfo.php?eg_id=EG20044 EnsemblBacteria AAC76553 http://www.ensemblgenomes.org/id/AAC76553 EnsemblBacteria AAC76553 http://www.ensemblgenomes.org/id/AAC76553 EnsemblBacteria BAE77766 http://www.ensemblgenomes.org/id/BAE77766 EnsemblBacteria BAE77766 http://www.ensemblgenomes.org/id/BAE77766 EnsemblBacteria BAE77766 http://www.ensemblgenomes.org/id/BAE77766 EnsemblBacteria b3528 http://www.ensemblgenomes.org/id/b3528 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015138 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015138 GO_function GO:0015141 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015141 GO_function GO:0015183 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015183 GO_function GO:0015366 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015366 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0015741 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015741 GO_process GO:0070778 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070778 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 1.10.3860.10 http://www.cathdb.info/version/latest/superfamily/1.10.3860.10 GeneID 948039 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948039 HAMAP MF_01300 http://hamap.expasy.org/unirule/MF_01300 HOGENOM HOG000208775 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000208775&db=HOGENOM6 InParanoid P0A830 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A830 IntAct P0A830 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A830* InterPro IPR001991 http://www.ebi.ac.uk/interpro/entry/IPR001991 InterPro IPR018107 http://www.ebi.ac.uk/interpro/entry/IPR018107 InterPro IPR023954 http://www.ebi.ac.uk/interpro/entry/IPR023954 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW3496 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3496 KEGG_Gene eco:b3528 http://www.genome.jp/dbget-bin/www_bget?eco:b3528 KEGG_Orthology KO:K11103 http://www.genome.jp/dbget-bin/www_bget?KO:K11103 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 MINT MINT-1288518 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1288518 OMA IKMERLG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IKMERLG PANTHER PTHR11958 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11958 PRINTS PR00173 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00173 PROSITE PS00713 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00713 PROSITE PS00714 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00714 PSORT swissprot:DCTA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DCTA_ECOLI PSORT-B swissprot:DCTA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DCTA_ECOLI PSORT2 swissprot:DCTA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DCTA_ECOLI Pfam PF00375 http://pfam.xfam.org/family/PF00375 Phobius swissprot:DCTA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DCTA_ECOLI PhylomeDB P0A830 http://phylomedb.org/?seqid=P0A830 ProteinModelPortal P0A830 http://www.proteinmodelportal.org/query/uniprot/P0A830 PubMed 10482502 http://www.ncbi.nlm.nih.gov/pubmed/10482502 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17088549 http://www.ncbi.nlm.nih.gov/pubmed/17088549 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417985 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417985 RefSeq WP_000858214 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000858214 STRING 511145.b3528 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3528&targetmode=cogs STRING COG1301 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1301&targetmode=cogs SUPFAM SSF118215 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF118215 TCDB 2.A.23.1 http://www.tcdb.org/search/result.php?tc=2.A.23.1 UniProtKB DCTA_ECOLI http://www.uniprot.org/uniprot/DCTA_ECOLI UniProtKB-AC P0A830 http://www.uniprot.org/uniprot/P0A830 charge swissprot:DCTA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DCTA_ECOLI eggNOG COG1301 http://eggnogapi.embl.de/nog_data/html/tree/COG1301 eggNOG ENOG4105CK2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CK2 epestfind swissprot:DCTA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DCTA_ECOLI garnier swissprot:DCTA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DCTA_ECOLI helixturnhelix swissprot:DCTA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DCTA_ECOLI hmoment swissprot:DCTA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DCTA_ECOLI iep swissprot:DCTA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DCTA_ECOLI inforesidue swissprot:DCTA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DCTA_ECOLI octanol swissprot:DCTA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DCTA_ECOLI pepcoil swissprot:DCTA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DCTA_ECOLI pepdigest swissprot:DCTA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DCTA_ECOLI pepinfo swissprot:DCTA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DCTA_ECOLI pepnet swissprot:DCTA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DCTA_ECOLI pepstats swissprot:DCTA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DCTA_ECOLI pepwheel swissprot:DCTA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DCTA_ECOLI pepwindow swissprot:DCTA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DCTA_ECOLI sigcleave swissprot:DCTA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DCTA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261635 13 # EcoGene EG12445 eamB # FUNCTION EAMB_ECOLI Exporter of O-acetylserine (OAS) and cysteine. {ECO 0000269|PubMed 12562784}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_function GO:0033229 cysteine transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0033228 cysteine export; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR001123 LysE-type # KEGG_Brite ko02000 Transporters # Organism EAMB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30086 PTHR30086 # PATRIC 32120557 VBIEscCol129921_2681 # PIR A65036 A65036 # Pfam PF01810 LysE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EAMB_ECOLI Cysteine/O-acetylserine efflux protein # RefSeq NP_417073 NC_000913.3 # RefSeq WP_000189207 NZ_LN832404.1 # SIMILARITY Belongs to the rht family. {ECO 0000305}. # SUBCELLULAR LOCATION EAMB_ECOLI Cell inner membrane {ECO 0000269|PubMed 12562784}; Multi-pass membrane protein {ECO 0000269|PubMed 12562784}. # TCDB 2.A.76.1 the resistance to homoserine/threonine (rhtb) family # eggNOG COG1280 LUCA # eggNOG ENOG4108VP3 Bacteria BLAST swissprot:EAMB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EAMB_ECOLI BioCyc ECOL316407:JW2562-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2562-MONOMER BioCyc EcoCyc:EG12445-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12445-MONOMER BioCyc MetaCyc:EG12445-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12445-MONOMER COG COG1280 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1280 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.185.4.1161-1166.2003 http://dx.doi.org/10.1128/JB.185.4.1161-1166.2003 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D13169 http://www.ebi.ac.uk/ena/data/view/D13169 EMBL D64044 http://www.ebi.ac.uk/ena/data/view/D64044 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2339 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2339 EcoGene EG12445 http://www.ecogene.org/geneInfo.php?eg_id=EG12445 EnsemblBacteria AAC75631 http://www.ensemblgenomes.org/id/AAC75631 EnsemblBacteria AAC75631 http://www.ensemblgenomes.org/id/AAC75631 EnsemblBacteria BAA16464 http://www.ensemblgenomes.org/id/BAA16464 EnsemblBacteria BAA16464 http://www.ensemblgenomes.org/id/BAA16464 EnsemblBacteria BAA16464 http://www.ensemblgenomes.org/id/BAA16464 EnsemblBacteria b2578 http://www.ensemblgenomes.org/id/b2578 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0033229 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033229 GO_process GO:0033228 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033228 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 947065 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947065 HOGENOM HOG000122950 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122950&db=HOGENOM6 InParanoid P38101 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P38101 InterPro IPR001123 http://www.ebi.ac.uk/interpro/entry/IPR001123 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2562 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2562 KEGG_Gene eco:b2578 http://www.genome.jp/dbget-bin/www_bget?eco:b2578 KEGG_Orthology KO:K11249 http://www.genome.jp/dbget-bin/www_bget?KO:K11249 OMA WIAWKIA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WIAWKIA PANTHER PTHR30086 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30086 PSORT swissprot:EAMB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EAMB_ECOLI PSORT-B swissprot:EAMB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EAMB_ECOLI PSORT2 swissprot:EAMB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EAMB_ECOLI Pfam PF01810 http://pfam.xfam.org/family/PF01810 Phobius swissprot:EAMB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EAMB_ECOLI PhylomeDB P38101 http://phylomedb.org/?seqid=P38101 ProteinModelPortal P38101 http://www.proteinmodelportal.org/query/uniprot/P38101 PubMed 12562784 http://www.ncbi.nlm.nih.gov/pubmed/12562784 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417073 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417073 RefSeq WP_000189207 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000189207 STRING 511145.b2578 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2578&targetmode=cogs STRING COG1280 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1280&targetmode=cogs TCDB 2.A.76.1 http://www.tcdb.org/search/result.php?tc=2.A.76.1 UniProtKB EAMB_ECOLI http://www.uniprot.org/uniprot/EAMB_ECOLI UniProtKB-AC P38101 http://www.uniprot.org/uniprot/P38101 charge swissprot:EAMB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EAMB_ECOLI eggNOG COG1280 http://eggnogapi.embl.de/nog_data/html/tree/COG1280 eggNOG ENOG4108VP3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108VP3 epestfind swissprot:EAMB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EAMB_ECOLI garnier swissprot:EAMB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EAMB_ECOLI helixturnhelix swissprot:EAMB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EAMB_ECOLI hmoment swissprot:EAMB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EAMB_ECOLI iep swissprot:EAMB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EAMB_ECOLI inforesidue swissprot:EAMB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EAMB_ECOLI octanol swissprot:EAMB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EAMB_ECOLI pepcoil swissprot:EAMB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EAMB_ECOLI pepdigest swissprot:EAMB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EAMB_ECOLI pepinfo swissprot:EAMB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EAMB_ECOLI pepnet swissprot:EAMB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EAMB_ECOLI pepstats swissprot:EAMB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EAMB_ECOLI pepwheel swissprot:EAMB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EAMB_ECOLI pepwindow swissprot:EAMB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EAMB_ECOLI sigcleave swissprot:EAMB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EAMB_ECOLI ## Database ID URL or Descriptions # BioGrid 4262633 7 # EcoGene EG11839 yihM # Gene3D 3.20.20.150 -; 1. # InterPro IPR013022 Xyl_isomerase-like_TIM-brl # Organism YIHM_ECOLI Escherichia coli (strain K12) # PATRIC 32123249 VBIEscCol129921_3985 # PIR S40818 S40818 # Pfam PF01261 AP_endonuc_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIHM_ECOLI Uncharacterized protein YihM # RefSeq NP_418309 NC_000913.3 # RefSeq WP_000256396 NZ_LN832404.1 # SUPFAM SSF51658 SSF51658 # eggNOG ENOG4108KHF Bacteria # eggNOG ENOG410ZVGB LUCA BLAST swissprot:YIHM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIHM_ECOLI BioCyc ECOL316407:JW3844-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3844-MONOMER BioCyc EcoCyc:EG11839-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11839-MONOMER DIP DIP-12494N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12494N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1785 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1785 EcoGene EG11839 http://www.ecogene.org/geneInfo.php?eg_id=EG11839 EnsemblBacteria AAC76870 http://www.ensemblgenomes.org/id/AAC76870 EnsemblBacteria AAC76870 http://www.ensemblgenomes.org/id/AAC76870 EnsemblBacteria BAE77436 http://www.ensemblgenomes.org/id/BAE77436 EnsemblBacteria BAE77436 http://www.ensemblgenomes.org/id/BAE77436 EnsemblBacteria BAE77436 http://www.ensemblgenomes.org/id/BAE77436 EnsemblBacteria b3873 http://www.ensemblgenomes.org/id/b3873 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.20.20.150 http://www.cathdb.info/version/latest/superfamily/3.20.20.150 GeneID 948367 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948367 HOGENOM HOG000009655 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009655&db=HOGENOM6 InParanoid P32134 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32134 IntAct P32134 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32134* InterPro IPR013022 http://www.ebi.ac.uk/interpro/entry/IPR013022 KEGG_Gene ecj:JW3844 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3844 KEGG_Gene eco:b3873 http://www.genome.jp/dbget-bin/www_bget?eco:b3873 MINT MINT-1289780 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1289780 OMA PQVMAYG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PQVMAYG PSORT swissprot:YIHM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIHM_ECOLI PSORT-B swissprot:YIHM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIHM_ECOLI PSORT2 swissprot:YIHM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIHM_ECOLI Pfam PF01261 http://pfam.xfam.org/family/PF01261 Phobius swissprot:YIHM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIHM_ECOLI PhylomeDB P32134 http://phylomedb.org/?seqid=P32134 ProteinModelPortal P32134 http://www.proteinmodelportal.org/query/uniprot/P32134 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418309 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418309 RefSeq WP_000256396 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000256396 SMR P32134 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32134 STRING 511145.b3873 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3873&targetmode=cogs SUPFAM SSF51658 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51658 UniProtKB YIHM_ECOLI http://www.uniprot.org/uniprot/YIHM_ECOLI UniProtKB-AC P32134 http://www.uniprot.org/uniprot/P32134 charge swissprot:YIHM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIHM_ECOLI eggNOG ENOG4108KHF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108KHF eggNOG ENOG410ZVGB http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZVGB epestfind swissprot:YIHM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIHM_ECOLI garnier swissprot:YIHM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIHM_ECOLI helixturnhelix swissprot:YIHM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIHM_ECOLI hmoment swissprot:YIHM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIHM_ECOLI iep swissprot:YIHM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIHM_ECOLI inforesidue swissprot:YIHM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIHM_ECOLI octanol swissprot:YIHM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIHM_ECOLI pepcoil swissprot:YIHM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIHM_ECOLI pepdigest swissprot:YIHM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIHM_ECOLI pepinfo swissprot:YIHM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIHM_ECOLI pepnet swissprot:YIHM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIHM_ECOLI pepstats swissprot:YIHM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIHM_ECOLI pepwheel swissprot:YIHM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIHM_ECOLI pepwindow swissprot:YIHM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIHM_ECOLI sigcleave swissprot:YIHM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIHM_ECOLI ## Database ID URL or Descriptions # BioGrid 4260681 5 # EcoGene EG13336 yafX # InterPro IPR004914 Antirestrict # Organism YAFX_ECOLI Escherichia coli (strain K12) # PATRIC 32115613 VBIEscCol129921_0250 # PIR H64749 H64749 # Pfam PF03230 Antirestrict # ProDom PD012854 Antirestrict # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAFX_ECOLI Uncharacterized protein YafX # RefSeq NP_414782 NC_000913.3 # RefSeq WP_000211838 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB08668.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the antirestriction protein family. {ECO 0000305}. # eggNOG ENOG4106549 Bacteria # eggNOG ENOG41128J2 LUCA BLAST swissprot:YAFX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAFX_ECOLI BioCyc ECOL316407:JW5022-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5022-MONOMER BioCyc EcoCyc:G6123-MONOMER http://biocyc.org/getid?id=EcoCyc:G6123-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EchoBASE EB3120 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3120 EcoGene EG13336 http://www.ecogene.org/geneInfo.php?eg_id=EG13336 EnsemblBacteria AAC73351 http://www.ensemblgenomes.org/id/AAC73351 EnsemblBacteria AAC73351 http://www.ensemblgenomes.org/id/AAC73351 EnsemblBacteria BAA77917 http://www.ensemblgenomes.org/id/BAA77917 EnsemblBacteria BAA77917 http://www.ensemblgenomes.org/id/BAA77917 EnsemblBacteria BAA77917 http://www.ensemblgenomes.org/id/BAA77917 EnsemblBacteria b0248 http://www.ensemblgenomes.org/id/b0248 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 944931 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944931 HOGENOM HOG000124758 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000124758&db=HOGENOM6 InterPro IPR004914 http://www.ebi.ac.uk/interpro/entry/IPR004914 KEGG_Gene ecj:JW5022 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5022 KEGG_Gene eco:b0248 http://www.genome.jp/dbget-bin/www_bget?eco:b0248 OMA YHFLREY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YHFLREY PSORT swissprot:YAFX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAFX_ECOLI PSORT-B swissprot:YAFX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAFX_ECOLI PSORT2 swissprot:YAFX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAFX_ECOLI Pfam PF03230 http://pfam.xfam.org/family/PF03230 Phobius swissprot:YAFX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAFX_ECOLI PhylomeDB P75676 http://phylomedb.org/?seqid=P75676 ProteinModelPortal P75676 http://www.proteinmodelportal.org/query/uniprot/P75676 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414782 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414782 RefSeq WP_000211838 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000211838 SMR P75676 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75676 STRING 511145.b0248 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0248&targetmode=cogs UniProtKB YAFX_ECOLI http://www.uniprot.org/uniprot/YAFX_ECOLI UniProtKB-AC P75676 http://www.uniprot.org/uniprot/P75676 charge swissprot:YAFX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAFX_ECOLI eggNOG ENOG4106549 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106549 eggNOG ENOG41128J2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41128J2 epestfind swissprot:YAFX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAFX_ECOLI garnier swissprot:YAFX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAFX_ECOLI helixturnhelix swissprot:YAFX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAFX_ECOLI hmoment swissprot:YAFX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAFX_ECOLI iep swissprot:YAFX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAFX_ECOLI inforesidue swissprot:YAFX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAFX_ECOLI octanol swissprot:YAFX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAFX_ECOLI pepcoil swissprot:YAFX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAFX_ECOLI pepdigest swissprot:YAFX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAFX_ECOLI pepinfo swissprot:YAFX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAFX_ECOLI pepnet swissprot:YAFX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAFX_ECOLI pepstats swissprot:YAFX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAFX_ECOLI pepwheel swissprot:YAFX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAFX_ECOLI pepwindow swissprot:YAFX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAFX_ECOLI sigcleave swissprot:YAFX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAFX_ECOLI ## Database ID URL or Descriptions # BioGrid 4261521 14 # EcoGene EG13052 ygeV # GO_component GO:0005622 intracellular; IEA:GOC. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0043565 sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0000160 phosphorelay signal transduction system; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; ISS:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_component GO:0005622 intracellular # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.60 -; 1. # Gene3D 3.30.450.40 -; 1. # Gene3D 3.40.50.300 -; 1. # IntAct Q46802 14 # InterPro IPR000014 PAS # InterPro IPR002078 Sigma_54_int # InterPro IPR002197 HTH_Fis # InterPro IPR003593 AAA+_ATPase # InterPro IPR009057 Homeodomain-like # InterPro IPR025662 Sigma_54_int_dom_ATP-bd_1 # InterPro IPR025943 Sigma_54_int_dom_ATP-bd_2 # InterPro IPR025944 Sigma_54_int_dom_CS # InterPro IPR027417 P-loop_NTPase # InterPro IPR029016 GAF_dom-like # Organism YGEV_ECOLI Escherichia coli (strain K12) # PATRIC 32121148 VBIEscCol129921_2962 # PIR E65070 E65070 # PROSITE PS00675 SIGMA54_INTERACT_1 # PROSITE PS00676 SIGMA54_INTERACT_2 # PROSITE PS00688 SIGMA54_INTERACT_3 # PROSITE PS50045 SIGMA54_INTERACT_4 # PROSITE PS50112 PAS # Pfam PF00158 Sigma54_activat # Pfam PF02954 HTH_8 # Pfam PF13188 PAS_8 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGEV_ECOLI Uncharacterized sigma-54-dependent transcriptional regulator YgeV # RefSeq NP_417345 NC_000913.3 # RefSeq WP_000417791 NZ_LN832404.1 # SIMILARITY Contains 1 PAS (PER-ARNT-SIM) domain. {ECO:0000255|PROSITE-ProRule PRU00140}. # SIMILARITY Contains 1 sigma-54 factor interaction domain. {ECO:0000255|PROSITE-ProRule PRU00193}. # SMART SM00091 PAS # SMART SM00382 AAA # SUPFAM SSF46689 SSF46689 # SUPFAM SSF52540 SSF52540 # SUPFAM SSF55785 SSF55785 # eggNOG COG3829 LUCA # eggNOG ENOG4108JUB Bacteria BLAST swissprot:YGEV_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGEV_ECOLI BioCyc ECOL316407:JW2837-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2837-MONOMER BioCyc EcoCyc:G7488-MONOMER http://biocyc.org/getid?id=EcoCyc:G7488-MONOMER DIP DIP-12157N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12157N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 EchoBASE EB2864 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2864 EcoGene EG13052 http://www.ecogene.org/geneInfo.php?eg_id=EG13052 EnsemblBacteria AAC75907 http://www.ensemblgenomes.org/id/AAC75907 EnsemblBacteria AAC75907 http://www.ensemblgenomes.org/id/AAC75907 EnsemblBacteria BAE76935 http://www.ensemblgenomes.org/id/BAE76935 EnsemblBacteria BAE76935 http://www.ensemblgenomes.org/id/BAE76935 EnsemblBacteria BAE76935 http://www.ensemblgenomes.org/id/BAE76935 EnsemblBacteria b2869 http://www.ensemblgenomes.org/id/b2869 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 Gene3D 3.30.450.40 http://www.cathdb.info/version/latest/superfamily/3.30.450.40 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947320 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947320 HOGENOM HOG000058487 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000058487&db=HOGENOM6 InParanoid Q46802 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46802 IntAct Q46802 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46802* InterPro IPR000014 http://www.ebi.ac.uk/interpro/entry/IPR000014 InterPro IPR002078 http://www.ebi.ac.uk/interpro/entry/IPR002078 InterPro IPR002197 http://www.ebi.ac.uk/interpro/entry/IPR002197 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR025662 http://www.ebi.ac.uk/interpro/entry/IPR025662 InterPro IPR025943 http://www.ebi.ac.uk/interpro/entry/IPR025943 InterPro IPR025944 http://www.ebi.ac.uk/interpro/entry/IPR025944 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR029016 http://www.ebi.ac.uk/interpro/entry/IPR029016 KEGG_Gene ecj:JW2837 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2837 KEGG_Gene eco:b2869 http://www.genome.jp/dbget-bin/www_bget?eco:b2869 MINT MINT-1242950 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1242950 OMA MIENMDQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MIENMDQ PROSITE PS00675 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00675 PROSITE PS00676 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00676 PROSITE PS00688 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00688 PROSITE PS50045 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50045 PROSITE PS50112 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50112 PSORT swissprot:YGEV_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGEV_ECOLI PSORT-B swissprot:YGEV_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGEV_ECOLI PSORT2 swissprot:YGEV_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGEV_ECOLI Pfam PF00158 http://pfam.xfam.org/family/PF00158 Pfam PF02954 http://pfam.xfam.org/family/PF02954 Pfam PF13188 http://pfam.xfam.org/family/PF13188 Phobius swissprot:YGEV_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGEV_ECOLI PhylomeDB Q46802 http://phylomedb.org/?seqid=Q46802 ProteinModelPortal Q46802 http://www.proteinmodelportal.org/query/uniprot/Q46802 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417345 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417345 RefSeq WP_000417791 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000417791 SMART SM00091 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00091 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR Q46802 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46802 STRING 511145.b2869 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2869&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SUPFAM SSF55785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55785 UniProtKB YGEV_ECOLI http://www.uniprot.org/uniprot/YGEV_ECOLI UniProtKB-AC Q46802 http://www.uniprot.org/uniprot/Q46802 charge swissprot:YGEV_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGEV_ECOLI eggNOG COG3829 http://eggnogapi.embl.de/nog_data/html/tree/COG3829 eggNOG ENOG4108JUB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108JUB epestfind swissprot:YGEV_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGEV_ECOLI garnier swissprot:YGEV_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGEV_ECOLI helixturnhelix swissprot:YGEV_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGEV_ECOLI hmoment swissprot:YGEV_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGEV_ECOLI iep swissprot:YGEV_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGEV_ECOLI inforesidue swissprot:YGEV_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGEV_ECOLI octanol swissprot:YGEV_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGEV_ECOLI pepcoil swissprot:YGEV_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGEV_ECOLI pepdigest swissprot:YGEV_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGEV_ECOLI pepinfo swissprot:YGEV_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGEV_ECOLI pepnet swissprot:YGEV_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGEV_ECOLI pepstats swissprot:YGEV_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGEV_ECOLI pepwheel swissprot:YGEV_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGEV_ECOLI pepwindow swissprot:YGEV_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGEV_ECOLI sigcleave swissprot:YGEV_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGEV_ECOLI ## Database ID URL or Descriptions # BioGrid 4262845 260 # EcoGene EG13411 csgE # FUNCTION CSGE_ECOLI May be involved in the biogenesis of curli organelles. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0022610 biological adhesion; IMP:EcoCyc. # GO_process GO:0044010 single-species biofilm formation; IMP:EcoCyc. # GO_process GO:0071806 protein transmembrane transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0008150 biological_process # GOslim_process GO:0055085 transmembrane transport # InterPro IPR018900 Curli_CsgE # KEGG_Brite ko02044 Secretion system # Organism CSGE_ECOLI Escherichia coli (strain K12) # PATRIC 32117311 VBIEscCol129921_1078 # PDB 2NA4 NMR; -; A=22-129 # PIR S70785 S70785 # Pfam PF10627 CsgE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CSGE_ECOLI Curli production assembly/transport component CsgE # RefSeq NP_415557 NC_000913.3 # RefSeq WP_000833288 NZ_LN832404.1 # TCDB 1.B.48.1 the curli fiber subunit, csga, porin, csgg (csgg) family # eggNOG ENOG4108XDW Bacteria # eggNOG ENOG4111JH9 LUCA BLAST swissprot:CSGE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CSGE_ECOLI BioCyc ECOL316407:JW1022-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1022-MONOMER BioCyc EcoCyc:G6545-MONOMER http://biocyc.org/getid?id=EcoCyc:G6545-MONOMER DIP DIP-9329N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9329N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1995.mmi_18040661.x http://dx.doi.org/10.1111/j.1365-2958.1995.mmi_18040661.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AF081826 http://www.ebi.ac.uk/ena/data/view/AF081826 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X90754 http://www.ebi.ac.uk/ena/data/view/X90754 EchoBASE EB3187 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3187 EcoGene EG13411 http://www.ecogene.org/geneInfo.php?eg_id=EG13411 EnsemblBacteria AAC74123 http://www.ensemblgenomes.org/id/AAC74123 EnsemblBacteria AAC74123 http://www.ensemblgenomes.org/id/AAC74123 EnsemblBacteria BAA35820 http://www.ensemblgenomes.org/id/BAA35820 EnsemblBacteria BAA35820 http://www.ensemblgenomes.org/id/BAA35820 EnsemblBacteria BAA35820 http://www.ensemblgenomes.org/id/BAA35820 EnsemblBacteria b1039 http://www.ensemblgenomes.org/id/b1039 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0022610 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022610 GO_process GO:0044010 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044010 GO_process GO:0071806 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071806 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 945711 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945711 HOGENOM HOG000118929 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118929&db=HOGENOM6 InterPro IPR018900 http://www.ebi.ac.uk/interpro/entry/IPR018900 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW1022 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1022 KEGG_Gene eco:b1039 http://www.genome.jp/dbget-bin/www_bget?eco:b1039 KEGG_Orthology KO:K04337 http://www.genome.jp/dbget-bin/www_bget?KO:K04337 OMA QSEDAIN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QSEDAIN PDB 2NA4 http://www.ebi.ac.uk/pdbe-srv/view/entry/2NA4 PDBsum 2NA4 http://www.ebi.ac.uk/pdbsum/2NA4 PSORT swissprot:CSGE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CSGE_ECOLI PSORT-B swissprot:CSGE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CSGE_ECOLI PSORT2 swissprot:CSGE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CSGE_ECOLI Pfam PF10627 http://pfam.xfam.org/family/PF10627 Phobius swissprot:CSGE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CSGE_ECOLI ProteinModelPortal P0AE95 http://www.proteinmodelportal.org/query/uniprot/P0AE95 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8817489 http://www.ncbi.nlm.nih.gov/pubmed/8817489 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415557 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415557 RefSeq WP_000833288 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000833288 SMR P0AE95 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AE95 STRING 511145.b1039 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1039&targetmode=cogs TCDB 1.B.48.1 http://www.tcdb.org/search/result.php?tc=1.B.48.1 UniProtKB CSGE_ECOLI http://www.uniprot.org/uniprot/CSGE_ECOLI UniProtKB-AC P0AE95 http://www.uniprot.org/uniprot/P0AE95 charge swissprot:CSGE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CSGE_ECOLI eggNOG ENOG4108XDW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108XDW eggNOG ENOG4111JH9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111JH9 epestfind swissprot:CSGE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CSGE_ECOLI garnier swissprot:CSGE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CSGE_ECOLI helixturnhelix swissprot:CSGE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CSGE_ECOLI hmoment swissprot:CSGE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CSGE_ECOLI iep swissprot:CSGE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CSGE_ECOLI inforesidue swissprot:CSGE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CSGE_ECOLI octanol swissprot:CSGE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CSGE_ECOLI pepcoil swissprot:CSGE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CSGE_ECOLI pepdigest swissprot:CSGE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CSGE_ECOLI pepinfo swissprot:CSGE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CSGE_ECOLI pepnet swissprot:CSGE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CSGE_ECOLI pepstats swissprot:CSGE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CSGE_ECOLI pepwheel swissprot:CSGE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CSGE_ECOLI pepwindow swissprot:CSGE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CSGE_ECOLI sigcleave swissprot:CSGE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CSGE_ECOLI ## Database ID URL or Descriptions # BioGrid 4259866 252 # EcoGene EG11769 ybbC # INDUCTION Repressed by H-NS, induced by LeuO. Part of the rhsD- ybbC operon. {ECO:0000269|PubMed 19429622}. # IntAct P33668 3 # InterPro IPR028921 NTF2_fold_dom # Organism YBBC_ECOLI Escherichia coli (strain K12) # PATRIC 32116155 VBIEscCol129921_0519 # PIR A64781 A64781 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF15631 Imm-NTF2-2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBBC_ECOLI Uncharacterized protein YbbC # RefSeq NP_415031 NC_000913.3 # RefSeq WP_000877768 NZ_LN832404.1 BLAST swissprot:YBBC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBBC_ECOLI BioCyc ECOL316407:JW0487-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0487-MONOMER BioCyc EcoCyc:EG11769-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11769-MONOMER DIP DIP-11316N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11316N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/19.25.7177 http://dx.doi.org/10.1093/nar/19.25.7177 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00108-09 http://dx.doi.org/10.1128/JB.00108-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL X60999 http://www.ebi.ac.uk/ena/data/view/X60999 EchoBASE EB1719 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1719 EcoGene EG11769 http://www.ecogene.org/geneInfo.php?eg_id=EG11769 EnsemblBacteria AAC73600 http://www.ensemblgenomes.org/id/AAC73600 EnsemblBacteria AAC73600 http://www.ensemblgenomes.org/id/AAC73600 EnsemblBacteria BAE76277 http://www.ensemblgenomes.org/id/BAE76277 EnsemblBacteria BAE76277 http://www.ensemblgenomes.org/id/BAE76277 EnsemblBacteria BAE76277 http://www.ensemblgenomes.org/id/BAE76277 EnsemblBacteria b0498 http://www.ensemblgenomes.org/id/b0498 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945115 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945115 IntAct P33668 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33668* InterPro IPR028921 http://www.ebi.ac.uk/interpro/entry/IPR028921 KEGG_Gene ecj:JW0487 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0487 KEGG_Gene eco:b0498 http://www.genome.jp/dbget-bin/www_bget?eco:b0498 PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YBBC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBBC_ECOLI PSORT-B swissprot:YBBC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBBC_ECOLI PSORT2 swissprot:YBBC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBBC_ECOLI Pfam PF15631 http://pfam.xfam.org/family/PF15631 Phobius swissprot:YBBC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBBC_ECOLI ProteinModelPortal P33668 http://www.proteinmodelportal.org/query/uniprot/P33668 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1766878 http://www.ncbi.nlm.nih.gov/pubmed/1766878 PubMed 19429622 http://www.ncbi.nlm.nih.gov/pubmed/19429622 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415031 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415031 RefSeq WP_000877768 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000877768 STRING 511145.b0498 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0498&targetmode=cogs UniProtKB YBBC_ECOLI http://www.uniprot.org/uniprot/YBBC_ECOLI UniProtKB-AC P33668 http://www.uniprot.org/uniprot/P33668 charge swissprot:YBBC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBBC_ECOLI epestfind swissprot:YBBC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBBC_ECOLI garnier swissprot:YBBC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBBC_ECOLI helixturnhelix swissprot:YBBC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBBC_ECOLI hmoment swissprot:YBBC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBBC_ECOLI iep swissprot:YBBC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBBC_ECOLI inforesidue swissprot:YBBC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBBC_ECOLI octanol swissprot:YBBC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBBC_ECOLI pepcoil swissprot:YBBC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBBC_ECOLI pepdigest swissprot:YBBC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBBC_ECOLI pepinfo swissprot:YBBC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBBC_ECOLI pepnet swissprot:YBBC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBBC_ECOLI pepstats swissprot:YBBC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBBC_ECOLI pepwheel swissprot:YBBC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBBC_ECOLI pepwindow swissprot:YBBC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBBC_ECOLI sigcleave swissprot:YBBC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBBC_ECOLI ## Database ID URL or Descriptions # AltName INTQ_ECOLI Putative lambdoid prophage Qin defective integrase # BioGrid 4260817 24 # CAUTION May not be functional, the original sequence is interrupted by an IS2 element. {ECO 0000305}. # EcoGene EG13188 intQ # FUNCTION INTQ_ECOLI Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome (By similarity). {ECO 0000250}. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_process GO:0006310 DNA recombination; IEA:UniProtKB-KW. # GO_process GO:0015074 DNA integration; IEA:UniProtKB-KW. # GO_process GO:0046718 viral entry into host cell; IEA:UniProtKB-KW. # GO_process GO:0075713 establishment of integrated proviral latency; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0044403 symbiosis, encompassing mutualism through parasitism # Gene3D 1.10.150.130 -; 1. # Gene3D 1.10.443.10 -; 1. # INTERACTION INTQ_ECOLI P04994 xseA; NbExp=2; IntAct=EBI-559711, EBI-559703; # IntAct P76168 6 # InterPro IPR002104 Integrase_catalytic # InterPro IPR011010 DNA_brk_join_enz # InterPro IPR013762 Integrase-like_cat # InterPro IPR022000 DUF3596 # InterPro IPR023109 Integrase_recombinase_N # Organism INTQ_ECOLI Escherichia coli (strain K12) # PATRIC 48662472 VBIEscCol107702_1596 # PIR E64913 E64913 # Pfam PF00589 Phage_integrase # Pfam PF12167 DUF3596 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Putative defective protein IntQ {ECO 0000305} # SIMILARITY Belongs to the 'phage' integrase family. {ECO 0000305}. # SUPFAM SSF56349 SSF56349 # eggNOG COG0582 LUCA # eggNOG ENOG4107R08 Bacteria BLAST swissprot:INTQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INTQ_ECOLI BioCyc ECOL316407:JW1571-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1571-MONOMER BioCyc EcoCyc:G6837-MONOMER http://biocyc.org/getid?id=EcoCyc:G6837-MONOMER DIP DIP-10039N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10039N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG13188 http://www.ecogene.org/geneInfo.php?eg_id=EG13188 EnsemblBacteria BAE76475 http://www.ensemblgenomes.org/id/BAE76475 EnsemblBacteria BAE76475 http://www.ensemblgenomes.org/id/BAE76475 EnsemblBacteria BAE76475 http://www.ensemblgenomes.org/id/BAE76475 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0015074 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015074 GO_process GO:0046718 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046718 GO_process GO:0075713 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0075713 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0044403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403 Gene3D 1.10.150.130 http://www.cathdb.info/version/latest/superfamily/1.10.150.130 Gene3D 1.10.443.10 http://www.cathdb.info/version/latest/superfamily/1.10.443.10 HOGENOM HOG000120142 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120142&db=HOGENOM6 InParanoid P76168 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76168 IntAct P76168 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76168* InterPro IPR002104 http://www.ebi.ac.uk/interpro/entry/IPR002104 InterPro IPR011010 http://www.ebi.ac.uk/interpro/entry/IPR011010 InterPro IPR013762 http://www.ebi.ac.uk/interpro/entry/IPR013762 InterPro IPR022000 http://www.ebi.ac.uk/interpro/entry/IPR022000 InterPro IPR023109 http://www.ebi.ac.uk/interpro/entry/IPR023109 KEGG_Gene ecj:JW1571 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1571 OMA KQFPSSH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KQFPSSH PSORT swissprot:INTQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INTQ_ECOLI PSORT-B swissprot:INTQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INTQ_ECOLI PSORT2 swissprot:INTQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INTQ_ECOLI Pfam PF00589 http://pfam.xfam.org/family/PF00589 Pfam PF12167 http://pfam.xfam.org/family/PF12167 Phobius swissprot:INTQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INTQ_ECOLI PhylomeDB P76168 http://phylomedb.org/?seqid=P76168 ProteinModelPortal P76168 http://www.proteinmodelportal.org/query/uniprot/P76168 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SMR P76168 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76168 STRING 316407.85675030 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85675030&targetmode=cogs SUPFAM SSF56349 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56349 UniProtKB INTQ_ECOLI http://www.uniprot.org/uniprot/INTQ_ECOLI UniProtKB-AC P76168 http://www.uniprot.org/uniprot/P76168 charge swissprot:INTQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INTQ_ECOLI eggNOG COG0582 http://eggnogapi.embl.de/nog_data/html/tree/COG0582 eggNOG ENOG4107R08 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107R08 epestfind swissprot:INTQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INTQ_ECOLI garnier swissprot:INTQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INTQ_ECOLI helixturnhelix swissprot:INTQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INTQ_ECOLI hmoment swissprot:INTQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INTQ_ECOLI iep swissprot:INTQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INTQ_ECOLI inforesidue swissprot:INTQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INTQ_ECOLI octanol swissprot:INTQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INTQ_ECOLI pepcoil swissprot:INTQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INTQ_ECOLI pepdigest swissprot:INTQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INTQ_ECOLI pepinfo swissprot:INTQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INTQ_ECOLI pepnet swissprot:INTQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INTQ_ECOLI pepstats swissprot:INTQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INTQ_ECOLI pepwheel swissprot:INTQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INTQ_ECOLI pepwindow swissprot:INTQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INTQ_ECOLI sigcleave swissprot:INTQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INTQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4261346 9 # EcoGene EG12484 yjfI # IntAct P0AF76 10 # InterPro IPR019231 DUF2170 # Organism YJFI_ECOLI Escherichia coli (strain K12) # PATRIC 32123937 VBIEscCol129921_4313 # PIR S56406 S56406 # Pfam PF09938 DUF2170 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJFI_ECOLI Uncharacterized protein YjfI # RefSeq NP_418602 NC_000913.3 # RefSeq WP_000220128 NZ_LN832404.1 # eggNOG COG3789 LUCA # eggNOG ENOG4105FUX Bacteria BLAST swissprot:YJFI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJFI_ECOLI BioCyc ECOL316407:JW4139-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4139-MONOMER BioCyc EcoCyc:G7846-MONOMER http://biocyc.org/getid?id=EcoCyc:G7846-MONOMER COG COG3789 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3789 DIP DIP-48050N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48050N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2377 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2377 EcoGene EG12484 http://www.ecogene.org/geneInfo.php?eg_id=EG12484 EnsemblBacteria AAC77138 http://www.ensemblgenomes.org/id/AAC77138 EnsemblBacteria AAC77138 http://www.ensemblgenomes.org/id/AAC77138 EnsemblBacteria BAE78182 http://www.ensemblgenomes.org/id/BAE78182 EnsemblBacteria BAE78182 http://www.ensemblgenomes.org/id/BAE78182 EnsemblBacteria BAE78182 http://www.ensemblgenomes.org/id/BAE78182 EnsemblBacteria b4181 http://www.ensemblgenomes.org/id/b4181 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 948704 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948704 HOGENOM HOG000127331 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000127331&db=HOGENOM6 InParanoid P0AF76 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AF76 IntAct P0AF76 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AF76* InterPro IPR019231 http://www.ebi.ac.uk/interpro/entry/IPR019231 KEGG_Gene ecj:JW4139 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4139 KEGG_Gene eco:b4181 http://www.genome.jp/dbget-bin/www_bget?eco:b4181 KEGG_Orthology KO:K09980 http://www.genome.jp/dbget-bin/www_bget?KO:K09980 MINT MINT-1322513 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1322513 OMA EEWYELF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EEWYELF PSORT swissprot:YJFI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJFI_ECOLI PSORT-B swissprot:YJFI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJFI_ECOLI PSORT2 swissprot:YJFI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJFI_ECOLI Pfam PF09938 http://pfam.xfam.org/family/PF09938 Phobius swissprot:YJFI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJFI_ECOLI ProteinModelPortal P0AF76 http://www.proteinmodelportal.org/query/uniprot/P0AF76 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418602 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418602 RefSeq WP_000220128 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000220128 STRING 511145.b4181 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4181&targetmode=cogs STRING COG3789 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3789&targetmode=cogs UniProtKB YJFI_ECOLI http://www.uniprot.org/uniprot/YJFI_ECOLI UniProtKB-AC P0AF76 http://www.uniprot.org/uniprot/P0AF76 charge swissprot:YJFI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJFI_ECOLI eggNOG COG3789 http://eggnogapi.embl.de/nog_data/html/tree/COG3789 eggNOG ENOG4105FUX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FUX epestfind swissprot:YJFI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJFI_ECOLI garnier swissprot:YJFI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJFI_ECOLI helixturnhelix swissprot:YJFI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJFI_ECOLI hmoment swissprot:YJFI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJFI_ECOLI iep swissprot:YJFI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJFI_ECOLI inforesidue swissprot:YJFI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJFI_ECOLI octanol swissprot:YJFI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJFI_ECOLI pepcoil swissprot:YJFI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJFI_ECOLI pepdigest swissprot:YJFI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJFI_ECOLI pepinfo swissprot:YJFI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJFI_ECOLI pepnet swissprot:YJFI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJFI_ECOLI pepstats swissprot:YJFI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJFI_ECOLI pepwheel swissprot:YJFI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJFI_ECOLI pepwindow swissprot:YJFI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJFI_ECOLI sigcleave swissprot:YJFI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJFI_ECOLI ## Database ID URL or Descriptions # AltName HEM3_ECOLI Hydroxymethylbilane synthase # AltName HEM3_ECOLI Pre-uroporphyrinogen synthase # CATALYTIC ACTIVITY HEM3_ECOLI 4 porphobilinogen + H(2)O = hydroxymethylbilane + 4 NH(3). # COFACTOR Name=dipyrromethane; Xref=ChEBI:CHEBI 60342; Note=Binds 1 dipyrromethane group covalently.; # EcoGene EG10429 hemC # FUNCTION HEM3_ECOLI Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. {ECO 0000269|PubMed 3529035}. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004418 hydroxymethylbilane synthase activity; IDA:EcoCyc. # GO_process GO:0006782 protoporphyrinogen IX biosynthetic process; IDA:EcoCyc. # GO_process GO:0006783 heme biosynthetic process; IMP:EcoliWiki. # GO_process GO:0018160 peptidyl-pyrromethane cofactor linkage; IDA:EcoliWiki. # GO_process GO:0033014 tetrapyrrole biosynthetic process; IMP:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.30.160.40 -; 1. # HAMAP MF_00260 Porphobil_deam # InterPro IPR000860 HemC # InterPro IPR022417 Porphobilin_deaminase_N # InterPro IPR022418 Porphobilinogen_deaminase_C # InterPro IPR022419 Porphobilin_deaminase_cofac_BS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00860 Porphyrin and chlorophyll metabolism # MISCELLANEOUS HEM3_ECOLI Arginine residues that are closely associated with one another might be involved in substrate binding. # MISCELLANEOUS HEM3_ECOLI The porphobilinogen subunits are added to the dipyrromethane group. # Organism HEM3_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11557 PTHR11557 # PATHWAY Porphyrin-containing compound metabolism; protoporphyrin- IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate step 2/4. # PATRIC 32123109 VBIEscCol129921_3920 # PDB 1AH5 X-ray; 2.40 A; A=1-313 # PDB 1GTK X-ray; 1.66 A; A=1-313 # PDB 1PDA X-ray; 1.76 A; A=1-313 # PDB 1YPN X-ray; 2.30 A; A=1-313 # PDB 2YPN X-ray; 2.30 A; A=1-313 # PIR F65184 IBEC # PIRSF PIRSF001438 4pyrrol_synth_OHMeBilane_synth # PRINTS PR00151 PORPHBDMNASE # PROSITE PS00533 PORPHOBILINOGEN_DEAM # Pfam PF01379 Porphobil_deam # Pfam PF03900 Porphobil_deamC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HEM3_ECOLI Porphobilinogen deaminase # RefSeq WP_001338644 NZ_LN832404.1 # RefSeq YP_026260 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA67601.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the HMBS family. {ECO 0000305}. # SUBUNIT Monomer. {ECO:0000269|PubMed 3529035}. # SUPFAM SSF54782 SSF54782 # TIGRFAMs TIGR00212 hemC # UniPathway UPA00251 UER00319 # eggNOG COG0181 LUCA # eggNOG ENOG4105D6W Bacteria BLAST swissprot:HEM3_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HEM3_ECOLI BioCyc ECOL316407:JW5932-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5932-MONOMER BioCyc EcoCyc:OHMETHYLBILANESYN-MONOMER http://biocyc.org/getid?id=EcoCyc:OHMETHYLBILANESYN-MONOMER BioCyc MetaCyc:OHMETHYLBILANESYN-MONOMER http://biocyc.org/getid?id=MetaCyc:OHMETHYLBILANESYN-MONOMER COG COG0181 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0181 DIP DIP-9879N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9879N DOI 10.1016/0300-9084(96)82192-4 http://dx.doi.org/10.1016/0300-9084(96)82192-4 DOI 10.1038/359033a0 http://dx.doi.org/10.1038/359033a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2540427 http://dx.doi.org/10.1042/bj2540427 DOI 10.1042/bj2540915 http://dx.doi.org/10.1042/bj2540915 DOI 10.1042/bj2620119 http://dx.doi.org/10.1042/bj2620119 DOI 10.1042/bj2710487 http://dx.doi.org/10.1042/bj2710487 DOI 10.1042/bj2750447 http://dx.doi.org/10.1042/bj2750447 DOI 10.1042/bj2800445 http://dx.doi.org/10.1042/bj2800445 DOI 10.1093/nar/14.15.6215 http://dx.doi.org/10.1093/nar/14.15.6215 DOI 10.1093/nar/16.20.9871 http://dx.doi.org/10.1093/nar/16.20.9871 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.5.1.61 http://www.genome.jp/dbget-bin/www_bget?EC:2.5.1.61 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X04242 http://www.ebi.ac.uk/ena/data/view/X04242 EMBL X12614 http://www.ebi.ac.uk/ena/data/view/X12614 EMBL X66782 http://www.ebi.ac.uk/ena/data/view/X66782 ENZYME 2.5.1.61 http://enzyme.expasy.org/EC/2.5.1.61 EchoBASE EB0424 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0424 EcoGene EG10429 http://www.ecogene.org/geneInfo.php?eg_id=EG10429 EnsemblBacteria AAT48218 http://www.ensemblgenomes.org/id/AAT48218 EnsemblBacteria AAT48218 http://www.ensemblgenomes.org/id/AAT48218 EnsemblBacteria BAE77496 http://www.ensemblgenomes.org/id/BAE77496 EnsemblBacteria BAE77496 http://www.ensemblgenomes.org/id/BAE77496 EnsemblBacteria BAE77496 http://www.ensemblgenomes.org/id/BAE77496 EnsemblBacteria b3805 http://www.ensemblgenomes.org/id/b3805 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004418 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004418 GO_process GO:0006782 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006782 GO_process GO:0006783 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006783 GO_process GO:0018160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018160 GO_process GO:0033014 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033014 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016765 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.30.160.40 http://www.cathdb.info/version/latest/superfamily/3.30.160.40 GeneID 947759 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947759 HAMAP MF_00260 http://hamap.expasy.org/unirule/MF_00260 HOGENOM HOG000228588 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000228588&db=HOGENOM6 InParanoid P06983 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P06983 IntAct P06983 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P06983* IntEnz 2.5.1.61 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.5.1.61 InterPro IPR000860 http://www.ebi.ac.uk/interpro/entry/IPR000860 InterPro IPR022417 http://www.ebi.ac.uk/interpro/entry/IPR022417 InterPro IPR022418 http://www.ebi.ac.uk/interpro/entry/IPR022418 InterPro IPR022419 http://www.ebi.ac.uk/interpro/entry/IPR022419 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5932 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5932 KEGG_Gene eco:b3805 http://www.genome.jp/dbget-bin/www_bget?eco:b3805 KEGG_Orthology KO:K01749 http://www.genome.jp/dbget-bin/www_bget?KO:K01749 KEGG_Pathway ko00860 http://www.genome.jp/kegg-bin/show_pathway?ko00860 KEGG_Reaction rn:R00084 http://www.genome.jp/dbget-bin/www_bget?rn:R00084 MINT MINT-1302039 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1302039 OMA GIECRTD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GIECRTD PANTHER PTHR11557 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11557 PDB 1AH5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1AH5 PDB 1GTK http://www.ebi.ac.uk/pdbe-srv/view/entry/1GTK PDB 1PDA http://www.ebi.ac.uk/pdbe-srv/view/entry/1PDA PDB 1YPN http://www.ebi.ac.uk/pdbe-srv/view/entry/1YPN PDB 2YPN http://www.ebi.ac.uk/pdbe-srv/view/entry/2YPN PDBsum 1AH5 http://www.ebi.ac.uk/pdbsum/1AH5 PDBsum 1GTK http://www.ebi.ac.uk/pdbsum/1GTK PDBsum 1PDA http://www.ebi.ac.uk/pdbsum/1PDA PDBsum 1YPN http://www.ebi.ac.uk/pdbsum/1YPN PDBsum 2YPN http://www.ebi.ac.uk/pdbsum/2YPN PRINTS PR00151 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00151 PROSITE PS00533 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00533 PSORT swissprot:HEM3_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HEM3_ECOLI PSORT-B swissprot:HEM3_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HEM3_ECOLI PSORT2 swissprot:HEM3_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HEM3_ECOLI Pfam PF01379 http://pfam.xfam.org/family/PF01379 Pfam PF03900 http://pfam.xfam.org/family/PF03900 Phobius swissprot:HEM3_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HEM3_ECOLI PhylomeDB P06983 http://phylomedb.org/?seqid=P06983 ProteinModelPortal P06983 http://www.proteinmodelportal.org/query/uniprot/P06983 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 1522882 http://www.ncbi.nlm.nih.gov/pubmed/1522882 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1747120 http://www.ncbi.nlm.nih.gov/pubmed/1747120 PubMed 2025226 http://www.ncbi.nlm.nih.gov/pubmed/2025226 PubMed 2122889 http://www.ncbi.nlm.nih.gov/pubmed/2122889 PubMed 2510713 http://www.ncbi.nlm.nih.gov/pubmed/2510713 PubMed 3052434 http://www.ncbi.nlm.nih.gov/pubmed/3052434 PubMed 3054815 http://www.ncbi.nlm.nih.gov/pubmed/3054815 PubMed 3196304 http://www.ncbi.nlm.nih.gov/pubmed/3196304 PubMed 3529035 http://www.ncbi.nlm.nih.gov/pubmed/3529035 PubMed 8874804 http://www.ncbi.nlm.nih.gov/pubmed/8874804 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001338644 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001338644 RefSeq YP_026260 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026260 SMR P06983 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P06983 STRING 511145.b3805 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3805&targetmode=cogs STRING COG0181 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0181&targetmode=cogs SUPFAM SSF54782 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54782 TIGRFAMs TIGR00212 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00212 UniProtKB HEM3_ECOLI http://www.uniprot.org/uniprot/HEM3_ECOLI UniProtKB-AC P06983 http://www.uniprot.org/uniprot/P06983 charge swissprot:HEM3_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HEM3_ECOLI eggNOG COG0181 http://eggnogapi.embl.de/nog_data/html/tree/COG0181 eggNOG ENOG4105D6W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D6W epestfind swissprot:HEM3_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HEM3_ECOLI garnier swissprot:HEM3_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HEM3_ECOLI helixturnhelix swissprot:HEM3_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HEM3_ECOLI hmoment swissprot:HEM3_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HEM3_ECOLI iep swissprot:HEM3_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HEM3_ECOLI inforesidue swissprot:HEM3_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HEM3_ECOLI octanol swissprot:HEM3_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HEM3_ECOLI pepcoil swissprot:HEM3_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HEM3_ECOLI pepdigest swissprot:HEM3_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HEM3_ECOLI pepinfo swissprot:HEM3_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HEM3_ECOLI pepnet swissprot:HEM3_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HEM3_ECOLI pepstats swissprot:HEM3_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HEM3_ECOLI pepwheel swissprot:HEM3_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HEM3_ECOLI pepwindow swissprot:HEM3_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HEM3_ECOLI sigcleave swissprot:HEM3_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HEM3_ECOLI ## Database ID URL or Descriptions # BioGrid 4261347 8 # CATALYTIC ACTIVITY AMP + diphosphate = adenine + 5-phospho-alpha- D-ribose 1-diphosphate. {ECO:0000255|HAMAP-Rule MF_00004}. # CDD cd06223 PRTases_typeI # EcoGene EG10051 apt # FUNCTION APT_ECOLI Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0003999 adenine phosphoribosyltransferase activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0006168 adenine salvage; IDA:EcoCyc. # GO_process GO:0044209 AMP salvage; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.2020 -; 1. # HAMAP MF_00004 Aden_phosphoribosyltr # IntAct P69503 5 # InterPro IPR000836 PRibTrfase_dom # InterPro IPR005764 Ade_phspho_trans # InterPro IPR029057 PRTase-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # Organism APT_ECOLI Escherichia coli (strain K12) # PATHWAY Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1. {ECO 0000255|HAMAP-Rule:MF_00004}. # PATRIC 32116095 VBIEscCol129921_0489 # PDB 2DY0 X-ray; 1.25 A; A/B=1-183 # PIR A25635 RTECA # PROSITE PS00103 PUR_PYR_PR_TRANSFER # Pfam PF00156 Pribosyltran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Adenine phosphoribosyltransferase {ECO:0000255|HAMAP-Rule MF_00004} # RefSeq NP_415002 NC_000913.3 # RefSeq WP_000127356 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40223.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the purine/pyrimidine phosphoribosyltransferase family. {ECO:0000255|HAMAP- Rule MF_00004}. # SUBCELLULAR LOCATION APT_ECOLI Cytoplasm. # SUBUNIT APT_ECOLI Homodimer. # SUPFAM SSF53271 SSF53271 # TIGRFAMs TIGR01090 apt # UniPathway UPA00588 UER00646 # eggNOG COG0503 LUCA # eggNOG ENOG4109003 Bacteria BLAST swissprot:APT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:APT_ECOLI BioCyc ECOL316407:JW0458-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0458-MONOMER BioCyc EcoCyc:ADENPRIBOSYLTRAN-MONOMER http://biocyc.org/getid?id=EcoCyc:ADENPRIBOSYLTRAN-MONOMER BioCyc MetaCyc:ADENPRIBOSYLTRAN-MONOMER http://biocyc.org/getid?id=MetaCyc:ADENPRIBOSYLTRAN-MONOMER COG COG0503 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0503 DIP DIP-36165N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36165N DOI 10.1016/0378-1119(86)90218-0 http://dx.doi.org/10.1016/0378-1119(86)90218-0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/14.20.8091 http://dx.doi.org/10.1093/nar/14.20.8091 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.4.2.7 {ECO:0000255|HAMAP-Rule:MF_00004} http://www.genome.jp/dbget-bin/www_bget?EC:2.4.2.7 {ECO:0000255|HAMAP-Rule:MF_00004} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M14040 http://www.ebi.ac.uk/ena/data/view/M14040 EMBL M38777 http://www.ebi.ac.uk/ena/data/view/M38777 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL X04487 http://www.ebi.ac.uk/ena/data/view/X04487 ENZYME 2.4.2.7 {ECO:0000255|HAMAP-Rule:MF_00004} http://enzyme.expasy.org/EC/2.4.2.7 {ECO:0000255|HAMAP-Rule:MF_00004} EchoBASE EB0049 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0049 EcoGene EG10051 http://www.ecogene.org/geneInfo.php?eg_id=EG10051 EnsemblBacteria AAC73571 http://www.ensemblgenomes.org/id/AAC73571 EnsemblBacteria AAC73571 http://www.ensemblgenomes.org/id/AAC73571 EnsemblBacteria BAE76248 http://www.ensemblgenomes.org/id/BAE76248 EnsemblBacteria BAE76248 http://www.ensemblgenomes.org/id/BAE76248 EnsemblBacteria BAE76248 http://www.ensemblgenomes.org/id/BAE76248 EnsemblBacteria b0469 http://www.ensemblgenomes.org/id/b0469 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0003999 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003999 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0006168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006168 GO_process GO:0044209 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044209 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.2020 http://www.cathdb.info/version/latest/superfamily/3.40.50.2020 GeneID 945113 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945113 HAMAP MF_00004 http://hamap.expasy.org/unirule/MF_00004 HOGENOM HOG000036776 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000036776&db=HOGENOM6 InParanoid P69503 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P69503 IntAct P69503 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69503* IntEnz 2.4.2.7 {ECO:0000255|HAMAP-Rule:MF_00004} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.2.7 {ECO:0000255|HAMAP-Rule:MF_00004} InterPro IPR000836 http://www.ebi.ac.uk/interpro/entry/IPR000836 InterPro IPR005764 http://www.ebi.ac.uk/interpro/entry/IPR005764 InterPro IPR029057 http://www.ebi.ac.uk/interpro/entry/IPR029057 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0458 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0458 KEGG_Gene eco:b0469 http://www.genome.jp/dbget-bin/www_bget?eco:b0469 KEGG_Orthology KO:K00759 http://www.genome.jp/dbget-bin/www_bget?KO:K00759 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Reaction rn:R00190 http://www.genome.jp/dbget-bin/www_bget?rn:R00190 KEGG_Reaction rn:R01229 http://www.genome.jp/dbget-bin/www_bget?rn:R01229 KEGG_Reaction rn:R04378 http://www.genome.jp/dbget-bin/www_bget?rn:R04378 OMA ATVEIHA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ATVEIHA PDB 2DY0 http://www.ebi.ac.uk/pdbe-srv/view/entry/2DY0 PDBsum 2DY0 http://www.ebi.ac.uk/pdbsum/2DY0 PROSITE PS00103 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00103 PSORT swissprot:APT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:APT_ECOLI PSORT-B swissprot:APT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:APT_ECOLI PSORT2 swissprot:APT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:APT_ECOLI Pfam PF00156 http://pfam.xfam.org/family/PF00156 Phobius swissprot:APT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:APT_ECOLI PhylomeDB P69503 http://phylomedb.org/?seqid=P69503 ProteinModelPortal P69503 http://www.proteinmodelportal.org/query/uniprot/P69503 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3527873 http://www.ncbi.nlm.nih.gov/pubmed/3527873 PubMed 3534795 http://www.ncbi.nlm.nih.gov/pubmed/3534795 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9573169 http://www.ncbi.nlm.nih.gov/pubmed/9573169 RefSeq NP_415002 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415002 RefSeq WP_000127356 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000127356 SMR P69503 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69503 STRING 511145.b0469 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0469&targetmode=cogs STRING COG0503 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0503&targetmode=cogs SUPFAM SSF53271 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53271 SWISS-2DPAGE P69503 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P69503 TIGRFAMs TIGR01090 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01090 UniProtKB APT_ECOLI http://www.uniprot.org/uniprot/APT_ECOLI UniProtKB-AC P69503 http://www.uniprot.org/uniprot/P69503 charge swissprot:APT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:APT_ECOLI eggNOG COG0503 http://eggnogapi.embl.de/nog_data/html/tree/COG0503 eggNOG ENOG4109003 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4109003 epestfind swissprot:APT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:APT_ECOLI garnier swissprot:APT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:APT_ECOLI helixturnhelix swissprot:APT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:APT_ECOLI hmoment swissprot:APT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:APT_ECOLI iep swissprot:APT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:APT_ECOLI inforesidue swissprot:APT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:APT_ECOLI octanol swissprot:APT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:APT_ECOLI pepcoil swissprot:APT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:APT_ECOLI pepdigest swissprot:APT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:APT_ECOLI pepinfo swissprot:APT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:APT_ECOLI pepnet swissprot:APT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:APT_ECOLI pepstats swissprot:APT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:APT_ECOLI pepwheel swissprot:APT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:APT_ECOLI pepwindow swissprot:APT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:APT_ECOLI sigcleave swissprot:APT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:APT_ECOLI ## Database ID URL or Descriptions # AltName IMP--aspartate ligase {ECO:0000255|HAMAP-Rule MF_00011} # BRENDA 6.3.4 2026 # BioGrid 4262696 26 # CATALYTIC ACTIVITY GTP + IMP + L-aspartate = GDP + phosphate + N(6)-(1,2-dicarboxyethyl)-AMP. {ECO:0000255|HAMAP-Rule MF_00011}. # CDD cd03108 AdSS # COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI 18420; Note=Binds 1 Mg(2+) ion per subunit.; # EcoGene EG10790 purA # FUNCTION PURA_ECOLI Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. {ECO 0000255|HAMAP-Rule MF_00011}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0004019 adenylosuccinate synthase activity; IDA:EcoCyc. # GO_function GO:0005525 GTP binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006164 purine nucleotide biosynthetic process; IMP:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0015949 nucleobase-containing small molecule interconversion; IDA:EcoliWiki. # GO_process GO:0044208 'de novo' AMP biosynthetic process; IBA:GO_Central. # GO_process GO:0046040 IMP metabolic process; IBA:GO_Central. # GO_process GO:0046086 adenosine biosynthetic process; IMP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # HAMAP MF_00011 Adenylosucc_synth # IntAct P0A7D4 2 # InterPro IPR001114 Adenylosuccinate_synthetase # InterPro IPR018220 Adenylosuccin_syn_GTP-bd # InterPro IPR027417 P-loop_NTPase # InterPro IPR033128 Adenylosuccin_syn_Lys_AS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00250 Alanine, aspartate and glutamate metabolism # Organism PURA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11846 PTHR11846 # PATHWAY Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2. {ECO 0000255|HAMAP-Rule:MF_00011}. # PATRIC 32123927 VBIEscCol129921_4308 # PDB 1ADE X-ray; 2.00 A; A/B=2-432 # PDB 1ADI X-ray; 2.50 A; A/B=2-432 # PDB 1CG0 X-ray; 2.50 A; A=2-432 # PDB 1CG1 X-ray; 2.50 A; A=2-432 # PDB 1CG3 X-ray; 2.50 A; A=2-432 # PDB 1CG4 X-ray; 2.50 A; A=2-432 # PDB 1CH8 X-ray; 2.50 A; A=2-432 # PDB 1CIB X-ray; 2.30 A; A=2-432 # PDB 1GIM X-ray; 2.50 A; A=2-432 # PDB 1GIN X-ray; 2.80 A; A=2-432 # PDB 1HON X-ray; 2.30 A; A/B=2-432 # PDB 1HOO X-ray; 2.30 A; A/B=2-432 # PDB 1HOP X-ray; 2.30 A; A/B=2-432 # PDB 1JUY X-ray; 2.50 A; A=2-432 # PDB 1KJX X-ray; 2.60 A; A=1-432 # PDB 1KKB X-ray; 2.60 A; A=1-432 # PDB 1KKF X-ray; 2.60 A; A=1-432 # PDB 1KSZ X-ray; 2.80 A; A=2-432 # PDB 1NHT X-ray; 2.50 A; A=2-432 # PDB 1QF4 X-ray; 2.20 A; A=2-432 # PDB 1QF5 X-ray; 2.00 A; A=2-432 # PDB 1SON X-ray; 2.55 A; A=2-432 # PDB 1SOO X-ray; 2.60 A; A=2-432 # PDB 2GCQ X-ray; 2.00 A; A=2-432 # PIR S56402 AJECDS # PROSITE PS00513 ADENYLOSUCCIN_SYN_2 # PROSITE PS01266 ADENYLOSUCCIN_SYN_1 # Pfam PF00709 Adenylsucc_synt # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Adenylosuccinate synthetase {ECO:0000255|HAMAP-Rule MF_00011} # RefSeq NP_418598 NC_000913.3 # RefSeq WP_000527955 NZ_LN832404.1 # SIMILARITY Belongs to the adenylosuccinate synthetase family. {ECO:0000255|HAMAP-Rule MF_00011}. # SMART SM00788 Adenylsucc_synt # SUBCELLULAR LOCATION PURA_ECOLI Cytoplasm. # SUBUNIT PURA_ECOLI Homodimer. {ECO 0000255|HAMAP-Rule MF_00011, ECO 0000269|PubMed 10346917, ECO 0000269|PubMed 8961938, ECO 0000269|PubMed 9000627}. # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR00184 purA # UniPathway UPA00075 UER00335 # eggNOG COG0104 LUCA # eggNOG ENOG4105C91 Bacteria BLAST swissprot:PURA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PURA_ECOLI BioCyc ECOL316407:JW4135-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4135-MONOMER BioCyc EcoCyc:ADENYLOSUCCINATE-SYN-MONOMER http://biocyc.org/getid?id=EcoCyc:ADENYLOSUCCINATE-SYN-MONOMER BioCyc MetaCyc:ADENYLOSUCCINATE-SYN-MONOMER http://biocyc.org/getid?id=MetaCyc:ADENYLOSUCCINATE-SYN-MONOMER COG COG0104 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0104 DIP DIP-36219N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36219N DOI 10.1002/(SICI)1521-3773(19991102)38:21<3159::AID-ANIE3159>3.0.CO http://dx.doi.org/10.1002/(SICI)1521-3773(19991102)38:21<3159::AID-ANIE3159>3.0.CO DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1995.0629 http://dx.doi.org/10.1006/jmbi.1995.0629 DOI 10.1006/jmbi.1996.0693 http://dx.doi.org/10.1006/jmbi.1996.0693 DOI 10.1021/bi0607498 http://dx.doi.org/10.1021/bi0607498 DOI 10.1021/bi961758r http://dx.doi.org/10.1021/bi961758r DOI 10.1021/bi990159s http://dx.doi.org/10.1021/bi990159s DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.93.18.9431 http://dx.doi.org/10.1073/pnas.93.18.9431 DOI 10.1074/jbc.271.26.15407 http://dx.doi.org/10.1074/jbc.271.26.15407 DOI 10.1074/jbc.272.24.15200 http://dx.doi.org/10.1074/jbc.272.24.15200 DOI 10.1074/jbc.274.25.17505 http://dx.doi.org/10.1074/jbc.274.25.17505 DOI 10.1074/jbc.M109561200 http://dx.doi.org/10.1074/jbc.M109561200 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.3.4.4 {ECO:0000255|HAMAP-Rule:MF_00011} http://www.genome.jp/dbget-bin/www_bget?EC:6.3.4.4 {ECO:0000255|HAMAP-Rule:MF_00011} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J04199 http://www.ebi.ac.uk/ena/data/view/J04199 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 6.3.4.4 {ECO:0000255|HAMAP-Rule:MF_00011} http://enzyme.expasy.org/EC/6.3.4.4 {ECO:0000255|HAMAP-Rule:MF_00011} EchoBASE EB0783 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0783 EcoGene EG10790 http://www.ecogene.org/geneInfo.php?eg_id=EG10790 EnsemblBacteria AAC77134 http://www.ensemblgenomes.org/id/AAC77134 EnsemblBacteria AAC77134 http://www.ensemblgenomes.org/id/AAC77134 EnsemblBacteria BAE78178 http://www.ensemblgenomes.org/id/BAE78178 EnsemblBacteria BAE78178 http://www.ensemblgenomes.org/id/BAE78178 EnsemblBacteria BAE78178 http://www.ensemblgenomes.org/id/BAE78178 EnsemblBacteria b4177 http://www.ensemblgenomes.org/id/b4177 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0004019 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004019 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_process GO:0006164 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006164 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0015949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015949 GO_process GO:0044208 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044208 GO_process GO:0046040 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046040 GO_process GO:0046086 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046086 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 948695 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948695 HAMAP MF_00011 http://hamap.expasy.org/unirule/MF_00011 HOGENOM HOG000260959 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260959&db=HOGENOM6 InParanoid P0A7D4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7D4 IntAct P0A7D4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7D4* IntEnz 6.3.4.4 {ECO:0000255|HAMAP-Rule:MF_00011} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.4.4 {ECO:0000255|HAMAP-Rule:MF_00011} InterPro IPR001114 http://www.ebi.ac.uk/interpro/entry/IPR001114 InterPro IPR018220 http://www.ebi.ac.uk/interpro/entry/IPR018220 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR033128 http://www.ebi.ac.uk/interpro/entry/IPR033128 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4135 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4135 KEGG_Gene eco:b4177 http://www.genome.jp/dbget-bin/www_bget?eco:b4177 KEGG_Orthology KO:K01939 http://www.genome.jp/dbget-bin/www_bget?KO:K01939 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00250 http://www.genome.jp/kegg-bin/show_pathway?ko00250 KEGG_Reaction rn:R01135 http://www.genome.jp/dbget-bin/www_bget?rn:R01135 MINT MINT-1286548 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1286548 OMA FHHAKPI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FHHAKPI PANTHER PTHR11846 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11846 PDB 1ADE http://www.ebi.ac.uk/pdbe-srv/view/entry/1ADE PDB 1ADI http://www.ebi.ac.uk/pdbe-srv/view/entry/1ADI PDB 1CG0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1CG0 PDB 1CG1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1CG1 PDB 1CG3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1CG3 PDB 1CG4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1CG4 PDB 1CH8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1CH8 PDB 1CIB http://www.ebi.ac.uk/pdbe-srv/view/entry/1CIB PDB 1GIM http://www.ebi.ac.uk/pdbe-srv/view/entry/1GIM PDB 1GIN http://www.ebi.ac.uk/pdbe-srv/view/entry/1GIN PDB 1HON http://www.ebi.ac.uk/pdbe-srv/view/entry/1HON PDB 1HOO http://www.ebi.ac.uk/pdbe-srv/view/entry/1HOO PDB 1HOP http://www.ebi.ac.uk/pdbe-srv/view/entry/1HOP PDB 1JUY http://www.ebi.ac.uk/pdbe-srv/view/entry/1JUY PDB 1KJX http://www.ebi.ac.uk/pdbe-srv/view/entry/1KJX PDB 1KKB http://www.ebi.ac.uk/pdbe-srv/view/entry/1KKB PDB 1KKF http://www.ebi.ac.uk/pdbe-srv/view/entry/1KKF PDB 1KSZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1KSZ PDB 1NHT http://www.ebi.ac.uk/pdbe-srv/view/entry/1NHT PDB 1QF4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1QF4 PDB 1QF5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1QF5 PDB 1SON http://www.ebi.ac.uk/pdbe-srv/view/entry/1SON PDB 1SOO http://www.ebi.ac.uk/pdbe-srv/view/entry/1SOO PDB 2GCQ http://www.ebi.ac.uk/pdbe-srv/view/entry/2GCQ PDBsum 1ADE http://www.ebi.ac.uk/pdbsum/1ADE PDBsum 1ADI http://www.ebi.ac.uk/pdbsum/1ADI PDBsum 1CG0 http://www.ebi.ac.uk/pdbsum/1CG0 PDBsum 1CG1 http://www.ebi.ac.uk/pdbsum/1CG1 PDBsum 1CG3 http://www.ebi.ac.uk/pdbsum/1CG3 PDBsum 1CG4 http://www.ebi.ac.uk/pdbsum/1CG4 PDBsum 1CH8 http://www.ebi.ac.uk/pdbsum/1CH8 PDBsum 1CIB http://www.ebi.ac.uk/pdbsum/1CIB PDBsum 1GIM http://www.ebi.ac.uk/pdbsum/1GIM PDBsum 1GIN http://www.ebi.ac.uk/pdbsum/1GIN PDBsum 1HON http://www.ebi.ac.uk/pdbsum/1HON PDBsum 1HOO http://www.ebi.ac.uk/pdbsum/1HOO PDBsum 1HOP http://www.ebi.ac.uk/pdbsum/1HOP PDBsum 1JUY http://www.ebi.ac.uk/pdbsum/1JUY PDBsum 1KJX http://www.ebi.ac.uk/pdbsum/1KJX PDBsum 1KKB http://www.ebi.ac.uk/pdbsum/1KKB PDBsum 1KKF http://www.ebi.ac.uk/pdbsum/1KKF PDBsum 1KSZ http://www.ebi.ac.uk/pdbsum/1KSZ PDBsum 1NHT http://www.ebi.ac.uk/pdbsum/1NHT PDBsum 1QF4 http://www.ebi.ac.uk/pdbsum/1QF4 PDBsum 1QF5 http://www.ebi.ac.uk/pdbsum/1QF5 PDBsum 1SON http://www.ebi.ac.uk/pdbsum/1SON PDBsum 1SOO http://www.ebi.ac.uk/pdbsum/1SOO PDBsum 2GCQ http://www.ebi.ac.uk/pdbsum/2GCQ PROSITE PS00513 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00513 PROSITE PS01266 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01266 PSORT swissprot:PURA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PURA_ECOLI PSORT-B swissprot:PURA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PURA_ECOLI PSORT2 swissprot:PURA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PURA_ECOLI Pfam PF00709 http://pfam.xfam.org/family/PF00709 Phobius swissprot:PURA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PURA_ECOLI PhylomeDB P0A7D4 http://phylomedb.org/?seqid=P0A7D4 ProteinModelPortal P0A7D4 http://www.proteinmodelportal.org/query/uniprot/P0A7D4 PubMed 10346917 http://www.ncbi.nlm.nih.gov/pubmed/10346917 PubMed 10364182 http://www.ncbi.nlm.nih.gov/pubmed/10364182 PubMed 10556888 http://www.ncbi.nlm.nih.gov/pubmed/10556888 PubMed 11741996 http://www.ncbi.nlm.nih.gov/pubmed/11741996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16981730 http://www.ncbi.nlm.nih.gov/pubmed/16981730 PubMed 1733940 http://www.ncbi.nlm.nih.gov/pubmed/1733940 PubMed 2061308 http://www.ncbi.nlm.nih.gov/pubmed/2061308 PubMed 2108156 http://www.ncbi.nlm.nih.gov/pubmed/2108156 PubMed 3058695 http://www.ncbi.nlm.nih.gov/pubmed/3058695 PubMed 7490761 http://www.ncbi.nlm.nih.gov/pubmed/7490761 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8663109 http://www.ncbi.nlm.nih.gov/pubmed/8663109 PubMed 8790347 http://www.ncbi.nlm.nih.gov/pubmed/8790347 PubMed 8961938 http://www.ncbi.nlm.nih.gov/pubmed/8961938 PubMed 9000627 http://www.ncbi.nlm.nih.gov/pubmed/9000627 PubMed 9182542 http://www.ncbi.nlm.nih.gov/pubmed/9182542 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_418598 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418598 RefSeq WP_000527955 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000527955 SMART SM00788 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00788 SMR P0A7D4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7D4 STRING 511145.b4177 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4177&targetmode=cogs STRING COG0104 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0104&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SWISS-2DPAGE P0A7D4 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A7D4 TIGRFAMs TIGR00184 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00184 UniProtKB PURA_ECOLI http://www.uniprot.org/uniprot/PURA_ECOLI UniProtKB-AC P0A7D4 http://www.uniprot.org/uniprot/P0A7D4 charge swissprot:PURA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PURA_ECOLI eggNOG COG0104 http://eggnogapi.embl.de/nog_data/html/tree/COG0104 eggNOG ENOG4105C91 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C91 epestfind swissprot:PURA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PURA_ECOLI garnier swissprot:PURA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PURA_ECOLI helixturnhelix swissprot:PURA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PURA_ECOLI hmoment swissprot:PURA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PURA_ECOLI iep swissprot:PURA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PURA_ECOLI inforesidue swissprot:PURA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PURA_ECOLI octanol swissprot:PURA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PURA_ECOLI pepcoil swissprot:PURA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PURA_ECOLI pepdigest swissprot:PURA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PURA_ECOLI pepinfo swissprot:PURA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PURA_ECOLI pepnet swissprot:PURA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PURA_ECOLI pepstats swissprot:PURA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PURA_ECOLI pepwheel swissprot:PURA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PURA_ECOLI pepwindow swissprot:PURA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PURA_ECOLI sigcleave swissprot:PURA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PURA_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES ASNB_ECOLI Kinetic parameters KM=17 mM for ammonia {ECO 0000269|PubMed 12706338, ECO 0000269|PubMed 7907328}; KM=0.53 mM for aspartate (when assaying the ammonia-dependent synthetase reaction) {ECO 0000269|PubMed 12706338, ECO 0000269|PubMed 7907328}; KM=0.85 mM for aspartate (when assaying the glutamine-dependent synthetase reaction) {ECO 0000269|PubMed 12706338, ECO 0000269|PubMed 7907328}; KM=0.26 mM for ATP (when assaying the glutamine-dependent synthetase reaction) {ECO 0000269|PubMed 12706338, ECO 0000269|PubMed 7907328}; KM=0.66 mM for glutamine (when assaying the glutamine-dependent synthetase reaction) {ECO 0000269|PubMed 12706338, ECO 0000269|PubMed 7907328}; pH dependence Optimum pH is 6.5-8. {ECO 0000269|PubMed 7907328}; # BRENDA 6.3.5 2026 # BioGrid 4261812 406 # CATALYTIC ACTIVITY ASNB_ECOLI ATP + L-aspartate + L-glutamine + H(2)O = AMP + diphosphate + L-asparagine + L-glutamate. {ECO 0000269|PubMed 20853825, ECO 0000269|PubMed 7907328}. # CDD cd00712 AsnB # CDD cd01991 Asn_Synthase_B_C # ENZYME REGULATION Glutamine-dependent asparagine synthesis activity can be inhibited by aspartic acid analogs (such as a sulfinate derivative and (2S,3R)-2-amino-3-methylsuccinate) in vitro; the inhibition is competitive with respect to aspartate. {ECO:0000269|PubMed 8691431}. # EcoGene EG10092 asnB # FUNCTION ASNB_ECOLI Catalyzes the ATP-dependent conversion of aspartate into asparagine, using glutamine as a source of nitrogen. Can also use ammonia as the nitrogen source in vitro, albeit with lower efficiency. As nucleotide substrates, ATP and dATP are utilized at a similar rate in both the glutamine- and ammonia-dependent reactions, whereas GTP utilization is only 15% that of ATP, and CTP, UTP, ITP and XTP are very poor or not substrates. Also exhibits glutaminase activity. {ECO 0000269|PubMed 20853825, ECO 0000269|PubMed 6102982, ECO 0000269|PubMed 7907328}. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity; IDA:UniProtKB. # GO_function GO:0004071 aspartate-ammonia ligase activity; IDA:UniProtKB. # GO_function GO:0005524 ATP binding; IDA:UniProtKB. # GO_function GO:0016597 amino acid binding; IDA:UniProtKB. # GO_function GO:0042803 protein homodimerization activity; IBA:GO_Central. # GO_process GO:0006529 asparagine biosynthetic process; IDA:UniProtKB. # GO_process GO:0006541 glutamine metabolic process; IMP:EcoliWiki. # GO_process GO:0008652 cellular amino acid biosynthetic process; IMP:EcoliWiki. # GO_process GO:0009063 cellular amino acid catabolic process; IMP:EcoliWiki. # GO_process GO:0070981 L-asparagine biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.50.620 -; 1. # Gene3D 3.60.20.10 -; 1. # INTERACTION ASNB_ECOLI Self; NbExp=3; IntAct=EBI-549123, EBI-549123; # IntAct P22106 7 # InterPro IPR001962 Asn_synthase # InterPro IPR006426 Asn_synth_AEB # InterPro IPR014729 Rossmann-like_a/b/a_fold # InterPro IPR017932 GATase_2_dom # InterPro IPR029055 Ntn_hydrolases_N # InterPro IPR033738 AsnB_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # KEGG_Pathway ko00250 Alanine, aspartate and glutamate metabolism # KEGG_Pathway ko00910 Nitrogen metabolism # Organism ASNB_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-asparagine biosynthesis; L- asparagine from L-aspartate (L-Gln route) step 1/1. # PATRIC 32116529 VBIEscCol129921_0697 # PDB 1CT9 X-ray; 2.00 A; A/B/C/D=2-554 # PIR A36616 AJECN # PROSITE PS51278 GATASE_TYPE_2 # Pfam PF00733 Asn_synthase # Pfam PF13537 GATase_7 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ASNB_ECOLI Asparagine synthetase B [glutamine-hydrolyzing] # RefSeq NP_415200 NC_000913.3 # RefSeq WP_000337077 NZ_LN832404.1 # SIMILARITY Belongs to the asparagine synthetase family. {ECO 0000305}. # SIMILARITY Contains 1 glutamine amidotransferase type-2 domain. {ECO:0000255|PROSITE-ProRule PRU00609}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 10587437}. # SUPFAM SSF56235 SSF56235 # TIGRFAMs TIGR01536 asn_synth_AEB # UniPathway UPA00134 UER00195 # eggNOG COG0367 LUCA # eggNOG ENOG4105CAQ Bacteria BLAST swissprot:ASNB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ASNB_ECOLI BioCyc ECOL316407:JW0660-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0660-MONOMER BioCyc EcoCyc:ASNSYNB-MONOMER http://biocyc.org/getid?id=EcoCyc:ASNSYNB-MONOMER BioCyc MetaCyc:ASNSYNB-MONOMER http://biocyc.org/getid?id=MetaCyc:ASNSYNB-MONOMER COG COG0367 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0367 DIP DIP-9177N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9177N DOI 10.1016/S0003-9861(03)00118-8 http://dx.doi.org/10.1016/S0003-9861(03)00118-8 DOI 10.1021/bi005109y http://dx.doi.org/10.1021/bi005109y DOI 10.1021/bi1010688 http://dx.doi.org/10.1021/bi1010688 DOI 10.1021/bi9915768 http://dx.doi.org/10.1021/bi9915768 DOI 10.1021/jm9601009 http://dx.doi.org/10.1021/jm9601009 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.3.5.4 http://www.genome.jp/dbget-bin/www_bget?EC:6.3.5.4 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J05554 http://www.ebi.ac.uk/ena/data/view/J05554 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 6.3.5.4 http://enzyme.expasy.org/EC/6.3.5.4 EchoBASE EB0090 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0090 EcoGene EG10092 http://www.ecogene.org/geneInfo.php?eg_id=EG10092 EnsemblBacteria AAC73768 http://www.ensemblgenomes.org/id/AAC73768 EnsemblBacteria AAC73768 http://www.ensemblgenomes.org/id/AAC73768 EnsemblBacteria BAA35317 http://www.ensemblgenomes.org/id/BAA35317 EnsemblBacteria BAA35317 http://www.ensemblgenomes.org/id/BAA35317 EnsemblBacteria BAA35317 http://www.ensemblgenomes.org/id/BAA35317 EnsemblBacteria b0674 http://www.ensemblgenomes.org/id/b0674 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004066 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004066 GO_function GO:0004071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004071 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016597 GO_function GO:0042803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803 GO_process GO:0006529 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006529 GO_process GO:0006541 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006541 GO_process GO:0008652 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008652 GO_process GO:0009063 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009063 GO_process GO:0070981 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070981 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 Gene3D 3.60.20.10 http://www.cathdb.info/version/latest/superfamily/3.60.20.10 GeneID 945281 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945281 HOGENOM HOG000027493 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000027493&db=HOGENOM6 InParanoid P22106 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P22106 IntAct P22106 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P22106* IntEnz 6.3.5.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.5.4 InterPro IPR001962 http://www.ebi.ac.uk/interpro/entry/IPR001962 InterPro IPR006426 http://www.ebi.ac.uk/interpro/entry/IPR006426 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 InterPro IPR017932 http://www.ebi.ac.uk/interpro/entry/IPR017932 InterPro IPR029055 http://www.ebi.ac.uk/interpro/entry/IPR029055 InterPro IPR033738 http://www.ebi.ac.uk/interpro/entry/IPR033738 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW0660 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0660 KEGG_Gene eco:b0674 http://www.genome.jp/dbget-bin/www_bget?eco:b0674 KEGG_Orthology KO:K01953 http://www.genome.jp/dbget-bin/www_bget?KO:K01953 KEGG_Pathway ko00250 http://www.genome.jp/kegg-bin/show_pathway?ko00250 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Reaction rn:R00578 http://www.genome.jp/dbget-bin/www_bget?rn:R00578 MINT MINT-1306603 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1306603 OMA DWSGIYS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DWSGIYS PDB 1CT9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1CT9 PDBsum 1CT9 http://www.ebi.ac.uk/pdbsum/1CT9 PROSITE PS51278 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51278 PSORT swissprot:ASNB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ASNB_ECOLI PSORT-B swissprot:ASNB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ASNB_ECOLI PSORT2 swissprot:ASNB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ASNB_ECOLI Pfam PF00733 http://pfam.xfam.org/family/PF00733 Pfam PF13537 http://pfam.xfam.org/family/PF13537 Phobius swissprot:ASNB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ASNB_ECOLI PhylomeDB P22106 http://phylomedb.org/?seqid=P22106 ProteinModelPortal P22106 http://www.proteinmodelportal.org/query/uniprot/P22106 PubMed 10587437 http://www.ncbi.nlm.nih.gov/pubmed/10587437 PubMed 10852734 http://www.ncbi.nlm.nih.gov/pubmed/10852734 PubMed 12706338 http://www.ncbi.nlm.nih.gov/pubmed/12706338 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1973930 http://www.ncbi.nlm.nih.gov/pubmed/1973930 PubMed 20853825 http://www.ncbi.nlm.nih.gov/pubmed/20853825 PubMed 6102982 http://www.ncbi.nlm.nih.gov/pubmed/6102982 PubMed 7907328 http://www.ncbi.nlm.nih.gov/pubmed/7907328 PubMed 8691431 http://www.ncbi.nlm.nih.gov/pubmed/8691431 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415200 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415200 RefSeq WP_000337077 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000337077 SMR P22106 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P22106 STRING 511145.b0674 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0674&targetmode=cogs STRING COG0367 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0367&targetmode=cogs SUPFAM SSF56235 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56235 TIGRFAMs TIGR01536 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01536 UniProtKB ASNB_ECOLI http://www.uniprot.org/uniprot/ASNB_ECOLI UniProtKB-AC P22106 http://www.uniprot.org/uniprot/P22106 charge swissprot:ASNB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ASNB_ECOLI eggNOG COG0367 http://eggnogapi.embl.de/nog_data/html/tree/COG0367 eggNOG ENOG4105CAQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CAQ epestfind swissprot:ASNB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ASNB_ECOLI garnier swissprot:ASNB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ASNB_ECOLI helixturnhelix swissprot:ASNB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ASNB_ECOLI hmoment swissprot:ASNB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ASNB_ECOLI iep swissprot:ASNB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ASNB_ECOLI inforesidue swissprot:ASNB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ASNB_ECOLI octanol swissprot:ASNB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ASNB_ECOLI pepcoil swissprot:ASNB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ASNB_ECOLI pepdigest swissprot:ASNB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ASNB_ECOLI pepinfo swissprot:ASNB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ASNB_ECOLI pepnet swissprot:ASNB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ASNB_ECOLI pepstats swissprot:ASNB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ASNB_ECOLI pepwheel swissprot:ASNB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ASNB_ECOLI pepwindow swissprot:ASNB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ASNB_ECOLI sigcleave swissprot:ASNB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ASNB_ECOLI ## Database ID URL or Descriptions # BioGrid 4262879 13 # DISRUPTION PHENOTYPE Cells lacking this gene may lead to an altered expression of abgT. {ECO:0000269|PubMed 9829935}. # EcoGene EG13353 abgR # FUNCTION ABGR_ECOLI Could be the regulator of the abg operon. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # IntAct P77744 2 # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR005119 LysR_subst-bd # InterPro IPR011991 WHTH_DNA-bd_dom # KEGG_Brite ko03000 Transcription factors # Organism ABGR_ECOLI Escherichia coli (strain K12) # PATRIC 32117956 VBIEscCol129921_1398 # PIR F64883 F64883 # PRINTS PR00039 HTHLYSR # PROSITE PS50931 HTH_LYSR # Pfam PF00126 HTH_1 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ABGR_ECOLI HTH-type transcriptional regulator AbgR # RefSeq NP_415855 NC_000913.3 # RefSeq WP_000885458 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lysR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00253}. # SUPFAM SSF46785 SSF46785 # eggNOG ENOG4106KR7 Bacteria # eggNOG ENOG410XQ2C LUCA BLAST swissprot:ABGR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ABGR_ECOLI BioCyc ECOL316407:JW1333-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1333-MONOMER BioCyc EcoCyc:G6671-MONOMER http://biocyc.org/getid?id=EcoCyc:G6671-MONOMER COG COG0583 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0583 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3136 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3136 EcoGene EG13353 http://www.ecogene.org/geneInfo.php?eg_id=EG13353 EnsemblBacteria AAC74421 http://www.ensemblgenomes.org/id/AAC74421 EnsemblBacteria AAC74421 http://www.ensemblgenomes.org/id/AAC74421 EnsemblBacteria BAA14941 http://www.ensemblgenomes.org/id/BAA14941 EnsemblBacteria BAA14941 http://www.ensemblgenomes.org/id/BAA14941 EnsemblBacteria BAA14941 http://www.ensemblgenomes.org/id/BAA14941 EnsemblBacteria b1339 http://www.ensemblgenomes.org/id/b1339 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 945831 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945831 HOGENOM HOG000233526 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000233526&db=HOGENOM6 InParanoid P77744 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77744 IntAct P77744 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77744* InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW1333 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1333 KEGG_Gene eco:b1339 http://www.genome.jp/dbget-bin/www_bget?eco:b1339 KEGG_Orthology KO:K14057 http://www.genome.jp/dbget-bin/www_bget?KO:K14057 OMA KATYYLI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KATYYLI PRINTS PR00039 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00039 PROSITE PS50931 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50931 PSORT swissprot:ABGR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ABGR_ECOLI PSORT-B swissprot:ABGR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ABGR_ECOLI PSORT2 swissprot:ABGR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ABGR_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:ABGR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ABGR_ECOLI PhylomeDB P77744 http://phylomedb.org/?seqid=P77744 ProteinModelPortal P77744 http://www.proteinmodelportal.org/query/uniprot/P77744 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9829935 http://www.ncbi.nlm.nih.gov/pubmed/9829935 RefSeq NP_415855 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415855 RefSeq WP_000885458 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000885458 SMR P77744 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77744 STRING 511145.b1339 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1339&targetmode=cogs STRING COG0583 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0583&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB ABGR_ECOLI http://www.uniprot.org/uniprot/ABGR_ECOLI UniProtKB-AC P77744 http://www.uniprot.org/uniprot/P77744 charge swissprot:ABGR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ABGR_ECOLI eggNOG ENOG4106KR7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106KR7 eggNOG ENOG410XQ2C http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQ2C epestfind swissprot:ABGR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ABGR_ECOLI garnier swissprot:ABGR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ABGR_ECOLI helixturnhelix swissprot:ABGR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ABGR_ECOLI hmoment swissprot:ABGR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ABGR_ECOLI iep swissprot:ABGR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ABGR_ECOLI inforesidue swissprot:ABGR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ABGR_ECOLI octanol swissprot:ABGR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ABGR_ECOLI pepcoil swissprot:ABGR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ABGR_ECOLI pepdigest swissprot:ABGR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ABGR_ECOLI pepinfo swissprot:ABGR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ABGR_ECOLI pepnet swissprot:ABGR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ABGR_ECOLI pepstats swissprot:ABGR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ABGR_ECOLI pepwheel swissprot:ABGR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ABGR_ECOLI pepwindow swissprot:ABGR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ABGR_ECOLI sigcleave swissprot:ABGR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ABGR_ECOLI ## Database ID URL or Descriptions # BioGrid 4260728 14 # CATALYTIC ACTIVITY MHPA_ECOLI (2E)-3-(3-hydroxyphenyl)prop-2-enoate + NADH + O(2) = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H(2)O + NAD(+). # CATALYTIC ACTIVITY MHPA_ECOLI 3-(3-hydroxyphenyl)propanoate + NADH + O(2) = 3-(2,3-dihydroxyphenyl)propanoate + H(2)O + NAD(+). # COFACTOR Name=FAD; Xref=ChEBI:CHEBI 57692; Evidence={ECO:0000250}; # EcoGene EG20273 mhpA # FUNCTION MHPA_ECOLI Catalyzes the insertion of one atom of molecular oxygen into position 2 of the phenyl ring of 3-(3- hydroxyphenyl)propionate (3-HPP) and hydroxycinnamic acid (3HCI). {ECO 0000269|PubMed 9603882}. # GO_function GO:0004497 monooxygenase activity; IBA:GO_Central. # GO_function GO:0008688 3-(3-hydroxyphenyl)propionate hydroxylase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0071949 FAD binding; IEA:InterPro. # GO_process GO:0019380 3-phenylpropionate catabolic process; IEA:UniProtKB-UniPathway. # GO_process GO:0019622 3-(3-hydroxy)phenylpropionate catabolic process; IEA:UniProtKB-HAMAP. # GO_process GO:0044550 secondary metabolite biosynthetic process; IBA:GO_Central. # GO_process GO:0046271 phenylpropanoid catabolic process; IMP:EcoCyc. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0019748 secondary metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.50.50.60 -; 2. # HAMAP MF_01652 MhpA # IntAct P77397 3 # InterPro IPR002938 FAD-bd # InterPro IPR023753 FAD/NAD-binding_dom # InterPro IPR023786 3-HPP/3HCI_hydroxylase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00360 Phenylalanine metabolism # Organism MHPA_ECOLI Escherichia coli (strain K12) # PATHWAY MHPA_ECOLI Aromatic compound metabolism; 3-phenylpropanoate degradation. # PATRIC 32115827 VBIEscCol129921_0355 # PIR C64762 C64762 # Pfam PF01494 FAD_binding_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MHPA_ECOLI 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase # RefSeq NP_414881 NC_000913.3 # RefSeq WP_001007407 NZ_LN832404.1 # SIMILARITY Belongs to the PheA/TfdB FAD monooxygenase family. {ECO 0000305}. # SUPFAM SSF51905 SSF51905; 2 # eggNOG COG0654 LUCA # eggNOG ENOG4105E2Q Bacteria BLAST swissprot:MHPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MHPA_ECOLI BioCyc ECOL316407:JW0338-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0338-MONOMER BioCyc EcoCyc:MHPHYDROXY-MONOMER http://biocyc.org/getid?id=EcoCyc:MHPHYDROXY-MONOMER BioCyc MetaCyc:MHPHYDROXY-MONOMER http://biocyc.org/getid?id=MetaCyc:MHPHYDROXY-MONOMER COG COG0654 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0654 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.14.13.127 http://www.genome.jp/dbget-bin/www_bget?EC:1.14.13.127 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D86239 http://www.ebi.ac.uk/ena/data/view/D86239 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EMBL Y09555 http://www.ebi.ac.uk/ena/data/view/Y09555 ENZYME 1.14.13.127 http://enzyme.expasy.org/EC/1.14.13.127 EchoBASE EB4166 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4166 EcoGene EG20273 http://www.ecogene.org/geneInfo.php?eg_id=EG20273 EnsemblBacteria AAC73450 http://www.ensemblgenomes.org/id/AAC73450 EnsemblBacteria AAC73450 http://www.ensemblgenomes.org/id/AAC73450 EnsemblBacteria BAE76129 http://www.ensemblgenomes.org/id/BAE76129 EnsemblBacteria BAE76129 http://www.ensemblgenomes.org/id/BAE76129 EnsemblBacteria BAE76129 http://www.ensemblgenomes.org/id/BAE76129 EnsemblBacteria b0347 http://www.ensemblgenomes.org/id/b0347 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004497 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004497 GO_function GO:0008688 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008688 GO_function GO:0071949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071949 GO_process GO:0019380 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019380 GO_process GO:0019622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019622 GO_process GO:0044550 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044550 GO_process GO:0046271 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046271 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0019748 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019748 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 GeneID 945197 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945197 HAMAP MF_01652 http://hamap.expasy.org/unirule/MF_01652 HOGENOM HOG000221401 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000221401&db=HOGENOM6 InParanoid P77397 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77397 IntAct P77397 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77397* IntEnz 1.14.13.127 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.14.13.127 InterPro IPR002938 http://www.ebi.ac.uk/interpro/entry/IPR002938 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 InterPro IPR023786 http://www.ebi.ac.uk/interpro/entry/IPR023786 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0338 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0338 KEGG_Gene eco:b0347 http://www.genome.jp/dbget-bin/www_bget?eco:b0347 KEGG_Orthology KO:K05712 http://www.genome.jp/dbget-bin/www_bget?KO:K05712 KEGG_Pathway ko00360 http://www.genome.jp/kegg-bin/show_pathway?ko00360 KEGG_Reaction rn:R06786 http://www.genome.jp/dbget-bin/www_bget?rn:R06786 KEGG_Reaction rn:R06787 http://www.genome.jp/dbget-bin/www_bget?rn:R06787 OMA RRVYTHH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RRVYTHH PSORT swissprot:MHPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MHPA_ECOLI PSORT-B swissprot:MHPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MHPA_ECOLI PSORT2 swissprot:MHPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MHPA_ECOLI Pfam PF01494 http://pfam.xfam.org/family/PF01494 Phobius swissprot:MHPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MHPA_ECOLI PhylomeDB P77397 http://phylomedb.org/?seqid=P77397 ProteinModelPortal P77397 http://www.proteinmodelportal.org/query/uniprot/P77397 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9098055 http://www.ncbi.nlm.nih.gov/pubmed/9098055 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9603882 http://www.ncbi.nlm.nih.gov/pubmed/9603882 RefSeq NP_414881 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414881 RefSeq WP_001007407 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001007407 STRING 511145.b0347 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0347&targetmode=cogs STRING COG0654 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0654&targetmode=cogs SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 UniProtKB MHPA_ECOLI http://www.uniprot.org/uniprot/MHPA_ECOLI UniProtKB-AC P77397 http://www.uniprot.org/uniprot/P77397 charge swissprot:MHPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MHPA_ECOLI eggNOG COG0654 http://eggnogapi.embl.de/nog_data/html/tree/COG0654 eggNOG ENOG4105E2Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E2Q epestfind swissprot:MHPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MHPA_ECOLI garnier swissprot:MHPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MHPA_ECOLI helixturnhelix swissprot:MHPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MHPA_ECOLI hmoment swissprot:MHPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MHPA_ECOLI iep swissprot:MHPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MHPA_ECOLI inforesidue swissprot:MHPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MHPA_ECOLI octanol swissprot:MHPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MHPA_ECOLI pepcoil swissprot:MHPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MHPA_ECOLI pepdigest swissprot:MHPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MHPA_ECOLI pepinfo swissprot:MHPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MHPA_ECOLI pepnet swissprot:MHPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MHPA_ECOLI pepstats swissprot:MHPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MHPA_ECOLI pepwheel swissprot:MHPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MHPA_ECOLI pepwindow swissprot:MHPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MHPA_ECOLI sigcleave swissprot:MHPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MHPA_ECOLI ## Database ID URL or Descriptions # AltName TAMA_ECOLI Autotransporter assembly factor TamA # BioGrid 4259308 242 # DISRUPTION PHENOTYPE TAMA_ECOLI Not essential, cells grow more slowly than wild-type. No changes in permeability or outer membrane integrity. Loss of localization of an exogenous protein, P1121 (ROD_p1121 of Citrobacter rodentium), to outer membranes, loss of cell aggregation when adhesins are over-expressed in a double tamA-tamB deletion mutant. {ECO 0000269|PubMed 17214547, ECO 0000269|PubMed 22466966}. # DOMAIN TAMA_ECOLI Contains 3 N-terminal periplasmic polypeptide transport- associated (POTRA) domains and a C-terminal transmembrane region. {ECO 0000305}. # EcoGene EG12513 tamA # FUNCTION TAMA_ECOLI Part of the translocation and assembly module (TAM) autotransporter assembly complex, which functions in translocation of autotransporters across the outer membrane. Has anion selective channel-forming ability, but the physiological relevance of this activity is unclear. {ECO 0000269|PubMed 22466966}. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_component GO:0045203 integral component of cell outer membrane; IDA:EcoliWiki. # GO_component GO:0097347 TAM protein secretion complex; IDA:EcoCyc. # GO_process GO:0009306 protein secretion; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043234 protein complex # GOslim_process GO:0006810 transport # IntAct P0ADE4 6 # InterPro IPR000184 Bac_surfAg_D15 # InterPro IPR010827 Surface_Ag_variable_number # Organism TAMA_ECOLI Escherichia coli (strain K12) # PATRIC 32124017 VBIEscCol129921_4353 # PDB 2LY3 NMR; -; 1=22-102 # PDB 4BZA X-ray; 1.84 A; A=22-275 # PDB 4C00 X-ray; 2.25 A; A=22-577 # PIR S56445 S56445 # PROSITE PS51779 POTRA # Pfam PF01103 Bac_surface_Ag # Pfam PF07244 POTRA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TAMA_ECOLI Translocation and assembly module TamA # RefSeq NP_418641 NC_000913.3 # RefSeq WP_001269327 NZ_LN832404.1 # SIMILARITY Belongs to the TamA family. {ECO 0000305}. # SIMILARITY Contains 1 POTRA domain. {ECO:0000255|PROSITE- ProRule PRU01115}. # SUBCELLULAR LOCATION TAMA_ECOLI Cell outer membrane {ECO 0000269|PubMed 17214547, ECO 0000269|PubMed 22466966}. # SUBUNIT Interacts with TamB. {ECO:0000269|PubMed 22466966}. # TCDB 1.B.33.2 the outer membrane protein insertion porin (bam complex) (ompip) family # eggNOG COG0729 LUCA # eggNOG ENOG4105CFU Bacteria BLAST swissprot:TAMA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TAMA_ECOLI BioCyc ECOL316407:JW4179-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4179-MONOMER BioCyc EcoCyc:G7874-MONOMER http://biocyc.org/getid?id=EcoCyc:G7874-MONOMER COG COG0729 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0729 DIP DIP-51058N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-51058N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsmb.2261 http://dx.doi.org/10.1038/nsmb.2261 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1515/BC.2007.004 http://dx.doi.org/10.1515/BC.2007.004 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2406 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2406 EcoGene EG12513 http://www.ecogene.org/geneInfo.php?eg_id=EG12513 EnsemblBacteria AAC77177 http://www.ensemblgenomes.org/id/AAC77177 EnsemblBacteria AAC77177 http://www.ensemblgenomes.org/id/AAC77177 EnsemblBacteria BAE78221 http://www.ensemblgenomes.org/id/BAE78221 EnsemblBacteria BAE78221 http://www.ensemblgenomes.org/id/BAE78221 EnsemblBacteria BAE78221 http://www.ensemblgenomes.org/id/BAE78221 EnsemblBacteria b4220 http://www.ensemblgenomes.org/id/b4220 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0045203 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045203 GO_component GO:0097347 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097347 GO_process GO:0009306 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009306 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948733 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948733 HOGENOM HOG000275353 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275353&db=HOGENOM6 InParanoid P0ADE4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADE4 IntAct P0ADE4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADE4* InterPro IPR000184 http://www.ebi.ac.uk/interpro/entry/IPR000184 InterPro IPR010827 http://www.ebi.ac.uk/interpro/entry/IPR010827 KEGG_Gene ecj:JW4179 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4179 KEGG_Gene eco:b4220 http://www.genome.jp/dbget-bin/www_bget?eco:b4220 KEGG_Orthology KO:K07278 http://www.genome.jp/dbget-bin/www_bget?KO:K07278 OMA WDSSSGW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WDSSSGW PDB 2LY3 http://www.ebi.ac.uk/pdbe-srv/view/entry/2LY3 PDB 4BZA http://www.ebi.ac.uk/pdbe-srv/view/entry/4BZA PDB 4C00 http://www.ebi.ac.uk/pdbe-srv/view/entry/4C00 PDBsum 2LY3 http://www.ebi.ac.uk/pdbsum/2LY3 PDBsum 4BZA http://www.ebi.ac.uk/pdbsum/4BZA PDBsum 4C00 http://www.ebi.ac.uk/pdbsum/4C00 PROSITE PS51779 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51779 PSORT swissprot:TAMA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TAMA_ECOLI PSORT-B swissprot:TAMA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TAMA_ECOLI PSORT2 swissprot:TAMA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TAMA_ECOLI Pfam PF01103 http://pfam.xfam.org/family/PF01103 Pfam PF07244 http://pfam.xfam.org/family/PF07244 Phobius swissprot:TAMA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TAMA_ECOLI PhylomeDB P0ADE4 http://phylomedb.org/?seqid=P0ADE4 ProteinModelPortal P0ADE4 http://www.proteinmodelportal.org/query/uniprot/P0ADE4 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17214547 http://www.ncbi.nlm.nih.gov/pubmed/17214547 PubMed 22466966 http://www.ncbi.nlm.nih.gov/pubmed/22466966 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418641 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418641 RefSeq WP_001269327 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001269327 SMR P0ADE4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADE4 STRING 511145.b4220 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4220&targetmode=cogs STRING COG0729 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0729&targetmode=cogs TCDB 1.B.33.2 http://www.tcdb.org/search/result.php?tc=1.B.33.2 UniProtKB TAMA_ECOLI http://www.uniprot.org/uniprot/TAMA_ECOLI UniProtKB-AC P0ADE4 http://www.uniprot.org/uniprot/P0ADE4 charge swissprot:TAMA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TAMA_ECOLI eggNOG COG0729 http://eggnogapi.embl.de/nog_data/html/tree/COG0729 eggNOG ENOG4105CFU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CFU epestfind swissprot:TAMA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TAMA_ECOLI garnier swissprot:TAMA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TAMA_ECOLI helixturnhelix swissprot:TAMA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TAMA_ECOLI hmoment swissprot:TAMA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TAMA_ECOLI iep swissprot:TAMA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TAMA_ECOLI inforesidue swissprot:TAMA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TAMA_ECOLI octanol swissprot:TAMA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TAMA_ECOLI pepcoil swissprot:TAMA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TAMA_ECOLI pepdigest swissprot:TAMA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TAMA_ECOLI pepinfo swissprot:TAMA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TAMA_ECOLI pepnet swissprot:TAMA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TAMA_ECOLI pepstats swissprot:TAMA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TAMA_ECOLI pepwheel swissprot:TAMA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TAMA_ECOLI pepwindow swissprot:TAMA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TAMA_ECOLI sigcleave swissprot:TAMA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TAMA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262795 116 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG13341 ykfC # InterPro IPR000477 RT_dom # Organism YKFC_ECOLI Escherichia coli (strain K12) # PATRIC 48659714 VBIEscCol107702_0253 # PIR B64751 B64751 # PROSITE PS50878 RT_POL # Pfam PF00078 RVT_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YKFC_ECOLI Putative uncharacterized protein YkfC # SEQUENCE CAUTION Sequence=BAA77927.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Contains 1 reverse transcriptase domain. {ECO:0000255|PROSITE-ProRule PRU00405}. # eggNOG COG3344 LUCA # eggNOG ENOG4105EKQ Bacteria BLAST swissprot:YKFC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YKFC_ECOLI BioCyc ECOL316407:JW5813-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5813-MONOMER BioCyc EcoCyc:G6133-MONOMER http://biocyc.org/getid?id=EcoCyc:G6133-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EchoBASE EB3125 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3125 EcoGene EG13341 http://www.ecogene.org/geneInfo.php?eg_id=EG13341 EnsemblBacteria BAA77927 http://www.ensemblgenomes.org/id/BAA77927 EnsemblBacteria BAA77927 http://www.ensemblgenomes.org/id/BAA77927 EnsemblBacteria BAA77927 http://www.ensemblgenomes.org/id/BAA77927 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv HOGENOM HOG000000651 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000000651&db=HOGENOM6 InParanoid Q47688 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q47688 InterPro IPR000477 http://www.ebi.ac.uk/interpro/entry/IPR000477 KEGG_Gene ecj:JW5813 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5813 OMA IPHVNDG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IPHVNDG PROSITE PS50878 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50878 PSORT swissprot:YKFC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YKFC_ECOLI PSORT-B swissprot:YKFC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YKFC_ECOLI PSORT2 swissprot:YKFC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YKFC_ECOLI Pfam PF00078 http://pfam.xfam.org/family/PF00078 Phobius swissprot:YKFC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YKFC_ECOLI PhylomeDB Q47688 http://phylomedb.org/?seqid=Q47688 ProteinModelPortal Q47688 http://www.proteinmodelportal.org/query/uniprot/Q47688 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 UniProtKB YKFC_ECOLI http://www.uniprot.org/uniprot/YKFC_ECOLI UniProtKB-AC Q47688 http://www.uniprot.org/uniprot/Q47688 charge swissprot:YKFC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YKFC_ECOLI eggNOG COG3344 http://eggnogapi.embl.de/nog_data/html/tree/COG3344 eggNOG ENOG4105EKQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EKQ epestfind swissprot:YKFC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YKFC_ECOLI garnier swissprot:YKFC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YKFC_ECOLI helixturnhelix swissprot:YKFC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YKFC_ECOLI hmoment swissprot:YKFC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YKFC_ECOLI iep swissprot:YKFC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YKFC_ECOLI inforesidue swissprot:YKFC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YKFC_ECOLI octanol swissprot:YKFC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YKFC_ECOLI pepcoil swissprot:YKFC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YKFC_ECOLI pepdigest swissprot:YKFC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YKFC_ECOLI pepinfo swissprot:YKFC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YKFC_ECOLI pepnet swissprot:YKFC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YKFC_ECOLI pepstats swissprot:YKFC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YKFC_ECOLI pepwheel swissprot:YKFC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YKFC_ECOLI pepwindow swissprot:YKFC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YKFC_ECOLI sigcleave swissprot:YKFC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YKFC_ECOLI ## Database ID URL or Descriptions # BioGrid 4259332 5 # EcoGene EG12378 yecD # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0016787 hydrolase activity; IEA:UniProtKB-KW. # GO_process GO:0008152 metabolic process; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.850 -; 1. # InterPro IPR000868 Isochorismatase-like # Organism YECD_ECOLI Escherichia coli (strain K12) # PATRIC 32119057 VBIEscCol129921_1946 # PDB 1J2R X-ray; 1.30 A; A/B/C/D=1-188 # PIR C64949 C64949 # Pfam PF00857 Isochorismatase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YECD_ECOLI Isochorismatase family protein YecD # RefSeq NP_416381 NC_000913.3 # RefSeq WP_000891621 NZ_LN832404.1 # SIMILARITY Belongs to the isochorismatase family. {ECO 0000305}. # SUPFAM SSF52499 SSF52499 # eggNOG COG1335 LUCA # eggNOG ENOG4105D3W Bacteria BLAST swissprot:YECD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YECD_ECOLI BioCyc ECOL316407:JW5307-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5307-MONOMER BioCyc EcoCyc:EG12378-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12378-MONOMER DOI 10.1023/A:1026177202925 http://dx.doi.org/10.1023/A:1026177202925 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/nar/18.23.7109 http://dx.doi.org/10.1093/nar/18.23.7109 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X53863 http://www.ebi.ac.uk/ena/data/view/X53863 ENZYME 3.-.-.- http://enzyme.expasy.org/EC/3.-.-.- EchoBASE EB2280 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2280 EcoGene EG12378 http://www.ecogene.org/geneInfo.php?eg_id=EG12378 EnsemblBacteria AAC74937 http://www.ensemblgenomes.org/id/AAC74937 EnsemblBacteria AAC74937 http://www.ensemblgenomes.org/id/AAC74937 EnsemblBacteria BAA15678 http://www.ensemblgenomes.org/id/BAA15678 EnsemblBacteria BAA15678 http://www.ensemblgenomes.org/id/BAA15678 EnsemblBacteria BAA15678 http://www.ensemblgenomes.org/id/BAA15678 EnsemblBacteria b1867 http://www.ensemblgenomes.org/id/b1867 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0016787 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016787 GO_process GO:0008152 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008152 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.850 http://www.cathdb.info/version/latest/superfamily/3.40.50.850 GeneID 946384 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946384 HOGENOM HOG000078668 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000078668&db=HOGENOM6 InParanoid P0ADI7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADI7 IntEnz 3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3 InterPro IPR000868 http://www.ebi.ac.uk/interpro/entry/IPR000868 KEGG_Gene ecj:JW5307 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5307 KEGG_Gene eco:b1867 http://www.genome.jp/dbget-bin/www_bget?eco:b1867 OMA NNGFIVF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NNGFIVF PDB 1J2R http://www.ebi.ac.uk/pdbe-srv/view/entry/1J2R PDBsum 1J2R http://www.ebi.ac.uk/pdbsum/1J2R PSORT swissprot:YECD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YECD_ECOLI PSORT-B swissprot:YECD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YECD_ECOLI PSORT2 swissprot:YECD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YECD_ECOLI Pfam PF00857 http://pfam.xfam.org/family/PF00857 Phobius swissprot:YECD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YECD_ECOLI PhylomeDB P0ADI7 http://phylomedb.org/?seqid=P0ADI7 ProteinModelPortal P0ADI7 http://www.proteinmodelportal.org/query/uniprot/P0ADI7 PubMed 14649299 http://www.ncbi.nlm.nih.gov/pubmed/14649299 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2129559 http://www.ncbi.nlm.nih.gov/pubmed/2129559 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416381 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416381 RefSeq WP_000891621 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000891621 SMR P0ADI7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADI7 STRING 511145.b1867 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1867&targetmode=cogs SUPFAM SSF52499 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52499 UniProtKB YECD_ECOLI http://www.uniprot.org/uniprot/YECD_ECOLI UniProtKB-AC P0ADI7 http://www.uniprot.org/uniprot/P0ADI7 charge swissprot:YECD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YECD_ECOLI eggNOG COG1335 http://eggnogapi.embl.de/nog_data/html/tree/COG1335 eggNOG ENOG4105D3W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D3W epestfind swissprot:YECD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YECD_ECOLI garnier swissprot:YECD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YECD_ECOLI helixturnhelix swissprot:YECD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YECD_ECOLI hmoment swissprot:YECD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YECD_ECOLI iep swissprot:YECD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YECD_ECOLI inforesidue swissprot:YECD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YECD_ECOLI octanol swissprot:YECD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YECD_ECOLI pepcoil swissprot:YECD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YECD_ECOLI pepdigest swissprot:YECD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YECD_ECOLI pepinfo swissprot:YECD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YECD_ECOLI pepnet swissprot:YECD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YECD_ECOLI pepstats swissprot:YECD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YECD_ECOLI pepwheel swissprot:YECD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YECD_ECOLI pepwindow swissprot:YECD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YECD_ECOLI sigcleave swissprot:YECD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YECD_ECOLI ## Database ID URL or Descriptions # AltName PTS system maltose-specific EIIB component {ECO:0000303|PubMed 1856179} # AltName PTS system maltose-specific EIIC component {ECO:0000303|PubMed 1856179} # AltName PTS system maltose-specific EIIC component {ECO:0000303|PubMed 1856179} # BioGrid 4261128 20 # CATALYTIC ACTIVITY [Protein]-N(pi)-phospho-L-histidine + maltose(Side 1) = [protein]-L-histidine + maltose 6'- phosphate(Side 2). {ECO:0000250|UniProtKB P54715}. # CDD cd00212 PTS_IIB_glc # DOMAIN PTOCB_ECOLI The EIIC domain type-1 forms the PTS system translocation channel and contains the specific substrate-binding site. {ECO 0000255|PROSITE-ProRule PRU00426}. # DOMAIN PTOCB_ECOLI The PTS EIIB type-1 domain is phosphorylated by phospho- EIIA on a cysteinyl residue. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the PTS EIIC type-1 domain. {ECO 0000255|PROSITE- ProRule PRU00421}. # EcoGene EG10563 malX # FUNCTION PTOCB_ECOLI The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in maltose transport. MalX can also recognize and transport glucose even though this sugar may not represent the natural substrate of the system. {ECO 0000269|PubMed 1856179}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0008982 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:InterPro. # GO_function GO:0016301 kinase activity; IEA:UniProtKB-KW. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW. # GO_process GO:0009758 carbohydrate utilization; IGI:CACAO. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # Gene3D 3.30.1360.60 -; 1. # INDUCTION By maltose. Repressed by MalI. {ECO:0000269|PubMed 1856179}. # INTERACTION PTOCB_ECOLI P21599 pykA; NbExp=3; IntAct=EBI-556578, EBI-368956; # InterPro IPR001996 PTS_IIB_1 # InterPro IPR003352 PTS_EIIC # InterPro IPR004719 PTS_maltose/Glc_sub_IIC # InterPro IPR011301 PTS_Mal/Glc-sp_IIBC_component # InterPro IPR013013 PTS_EIIC_1 # InterPro IPR018113 PTrfase_EIIB_Cys # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00266 PTS system, maltose and glucose-specific II component # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko00010 Glycolysis / Gluconeogenesis # KEGG_Pathway ko00500 Starch and sucrose metabolism # KEGG_Pathway ko02060 Phosphotransferase system (PTS) # Organism PTOCB_ECOLI Escherichia coli (strain K12) # PATRIC 32118544 VBIEscCol129921_1692 # PIR G64918 G64918 # PROSITE PS01035 PTS_EIIB_TYPE_1_CYS # PROSITE PS51098 PTS_EIIB_TYPE_1 # PROSITE PS51103 PTS_EIIC_TYPE_1 # Pfam PF00367 PTS_EIIB # Pfam PF02378 PTS_EIIC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Maltose permease IIC component {ECO:0000303|PubMed 1856179} # RecName Maltose-specific phosphotransferase enzyme IIB component {ECO:0000303|PubMed 1856179} # RecName PTS system maltose-specific EIICB component {ECO:0000303|PubMed 1856179} # RecName PTS system maltose-specific EIICB component {ECO:0000303|PubMed 1856179} # RefSeq NP_416138 NC_000913.3 # RefSeq WP_000125583 NZ_LN832404.1 # SIMILARITY Contains 1 PTS EIIB type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00421}. # SIMILARITY Contains 1 PTS EIIC type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00426}. # SUBCELLULAR LOCATION PTOCB_ECOLI Cell inner membrane {ECO 0000255|PROSITE- ProRule PRU00426, ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00426, ECO 0000269|PubMed 15919996}. # SUPFAM SSF55604 SSF55604 # TCDB 4.A.1.1 the pts glucose-glucoside (glc) family # TIGRFAMs TIGR00826 EIIB_glc # TIGRFAMs TIGR00852 pts-Glc # TIGRFAMs TIGR02004 PTS-IIBC-malX # eggNOG COG1263 LUCA # eggNOG COG1264 LUCA # eggNOG ENOG4105CI1 Bacteria BLAST swissprot:PTOCB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTOCB_ECOLI BioCyc ECOL316407:JW1613-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1613-MONOMER BioCyc EcoCyc:MALX-MONOMER http://biocyc.org/getid?id=EcoCyc:MALX-MONOMER BioCyc MetaCyc:MALX-MONOMER http://biocyc.org/getid?id=MetaCyc:MALX-MONOMER COG COG1263 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1263 DIP DIP-10150N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10150N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.208 {ECO:0000250|UniProtKB:P54715} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.208 {ECO:0000250|UniProtKB:P54715} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M28539 http://www.ebi.ac.uk/ena/data/view/M28539 EMBL M60722 http://www.ebi.ac.uk/ena/data/view/M60722 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.208 {ECO:0000250|UniProtKB:P54715} http://enzyme.expasy.org/EC/2.7.1.208 {ECO:0000250|UniProtKB:P54715} EchoBASE EB0558 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0558 EcoGene EG10563 http://www.ecogene.org/geneInfo.php?eg_id=EG10563 EnsemblBacteria AAC74693 http://www.ensemblgenomes.org/id/AAC74693 EnsemblBacteria AAC74693 http://www.ensemblgenomes.org/id/AAC74693 EnsemblBacteria BAA15372 http://www.ensemblgenomes.org/id/BAA15372 EnsemblBacteria BAA15372 http://www.ensemblgenomes.org/id/BAA15372 EnsemblBacteria BAA15372 http://www.ensemblgenomes.org/id/BAA15372 EnsemblBacteria b1621 http://www.ensemblgenomes.org/id/b1621 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008982 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008982 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GO_process GO:0009758 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009758 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.30.1360.60 http://www.cathdb.info/version/latest/superfamily/3.30.1360.60 GeneID 946009 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946009 HOGENOM HOG000250995 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000250995&db=HOGENOM6 InParanoid P19642 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P19642 IntAct P19642 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P19642* IntEnz 2.7.1.208 {ECO:0000250|UniProtKB:P54715} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.208 {ECO:0000250|UniProtKB:P54715} InterPro IPR001996 http://www.ebi.ac.uk/interpro/entry/IPR001996 InterPro IPR003352 http://www.ebi.ac.uk/interpro/entry/IPR003352 InterPro IPR004719 http://www.ebi.ac.uk/interpro/entry/IPR004719 InterPro IPR011301 http://www.ebi.ac.uk/interpro/entry/IPR011301 InterPro IPR013013 http://www.ebi.ac.uk/interpro/entry/IPR013013 InterPro IPR018113 http://www.ebi.ac.uk/interpro/entry/IPR018113 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1613 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1613 KEGG_Gene eco:b1621 http://www.genome.jp/dbget-bin/www_bget?eco:b1621 KEGG_Orthology KO:K02791 http://www.genome.jp/dbget-bin/www_bget?KO:K02791 KEGG_Pathway ko00010 http://www.genome.jp/kegg-bin/show_pathway?ko00010 KEGG_Pathway ko00500 http://www.genome.jp/kegg-bin/show_pathway?ko00500 KEGG_Pathway ko02060 http://www.genome.jp/kegg-bin/show_pathway?ko02060 KEGG_Reaction rn:R04111 http://www.genome.jp/dbget-bin/www_bget?rn:R04111 MINT MINT-1239961 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1239961 OMA GTMDVCG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GTMDVCG PROSITE PS01035 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01035 PROSITE PS51098 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51098 PROSITE PS51103 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51103 PSORT swissprot:PTOCB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTOCB_ECOLI PSORT-B swissprot:PTOCB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTOCB_ECOLI PSORT2 swissprot:PTOCB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTOCB_ECOLI Pfam PF00367 http://pfam.xfam.org/family/PF00367 Pfam PF02378 http://pfam.xfam.org/family/PF02378 Phobius swissprot:PTOCB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTOCB_ECOLI PhylomeDB P19642 http://phylomedb.org/?seqid=P19642 ProteinModelPortal P19642 http://www.proteinmodelportal.org/query/uniprot/P19642 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1856179 http://www.ncbi.nlm.nih.gov/pubmed/1856179 PubMed 2670898 http://www.ncbi.nlm.nih.gov/pubmed/2670898 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416138 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416138 RefSeq WP_000125583 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000125583 SMR P19642 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P19642 STRING 511145.b1621 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1621&targetmode=cogs STRING COG1263 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1263&targetmode=cogs SUPFAM SSF55604 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55604 TCDB 4.A.1.1 http://www.tcdb.org/search/result.php?tc=4.A.1.1 TIGRFAMs TIGR00826 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00826 TIGRFAMs TIGR00852 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00852 TIGRFAMs TIGR02004 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02004 UniProtKB PTOCB_ECOLI http://www.uniprot.org/uniprot/PTOCB_ECOLI UniProtKB-AC P19642 http://www.uniprot.org/uniprot/P19642 charge swissprot:PTOCB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTOCB_ECOLI eggNOG COG1263 http://eggnogapi.embl.de/nog_data/html/tree/COG1263 eggNOG COG1264 http://eggnogapi.embl.de/nog_data/html/tree/COG1264 eggNOG ENOG4105CI1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CI1 epestfind swissprot:PTOCB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTOCB_ECOLI garnier swissprot:PTOCB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTOCB_ECOLI helixturnhelix swissprot:PTOCB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTOCB_ECOLI hmoment swissprot:PTOCB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTOCB_ECOLI iep swissprot:PTOCB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTOCB_ECOLI inforesidue swissprot:PTOCB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTOCB_ECOLI octanol swissprot:PTOCB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTOCB_ECOLI pepcoil swissprot:PTOCB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTOCB_ECOLI pepdigest swissprot:PTOCB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTOCB_ECOLI pepinfo swissprot:PTOCB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTOCB_ECOLI pepnet swissprot:PTOCB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTOCB_ECOLI pepstats swissprot:PTOCB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTOCB_ECOLI pepwheel swissprot:PTOCB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTOCB_ECOLI pepwindow swissprot:PTOCB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTOCB_ECOLI sigcleave swissprot:PTOCB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTOCB_ECOLI ## Database ID URL or Descriptions # BioGrid 4261321 15 # EcoGene EG14241 clpS # FUNCTION CLPS_ECOLI Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation. {ECO 0000255|HAMAP-Rule MF_00302, ECO 0000269|PubMed 11931773}. # GO_function GO:0051087 chaperone binding; IPI:EcoCyc. # GO_process GO:0006508 proteolysis; IEA:UniProtKB-HAMAP. # GO_process GO:0009408 response to heat; IMP:EcoCyc. # GO_process GO:0030163 protein catabolic process; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # Gene3D 3.30.1390.10 -; 1. # HAMAP MF_00302 ClpS # INTERACTION CLPS_ECOLI P0ABH9 clpA; NbExp=10; IntAct=EBI-561456, EBI-546140; P0ABT2 dps; NbExp=5; IntAct=EBI-561456, EBI-549640; # IntAct P0A8Q6 43 # InterPro IPR003769 ClpS_core # InterPro IPR014719 Ribosomal_L7/12_C/ClpS-like # InterPro IPR022935 ClpS # Organism CLPS_ECOLI Escherichia coli (strain K12) # PATRIC 32116971 VBIEscCol129921_0911 # PDB 1LZW X-ray; 2.50 A; A=1-106 # PDB 1MBU X-ray; 2.30 A; C/D=1-106 # PDB 1MBV X-ray; 3.30 A; B=1-106 # PDB 1MBX X-ray; 2.25 A; C/D=1-106 # PDB 1MG9 X-ray; 2.30 A; A=1-106 # PDB 1R6O X-ray; 2.25 A; C/D=1-106 # PDB 1R6Q X-ray; 2.35 A; C/D=1-106 # PDB 2W9R X-ray; 1.70 A; A=1-106 # PDB 2WA8 X-ray; 2.15 A; A/C=1-106 # PDB 2WA9 X-ray; 2.90 A; A/B/C/D/E/F/G=1-106 # PDB 3O1F X-ray; 1.40 A; A/B=26-106 # PDB 3O2B X-ray; 2.05 A; A/C=2-106 # PDB 3O2H X-ray; 1.70 A; A=2-106 # PDB 3O2O X-ray; 2.90 A; A/B/C/D/E/F/G/H=22-106 # PIR A64827 A64827 # Pfam PF02617 ClpS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ATP-dependent Clp protease adapter protein ClpS {ECO:0000255|HAMAP-Rule MF_00302} # RefSeq NP_415402 NC_000913.3 # RefSeq WP_000520781 NZ_LN832404.1 # SIMILARITY Belongs to the ClpS family. {ECO:0000255|HAMAP- Rule MF_00302}. # SUBUNIT CLPS_ECOLI Binds to the N-terminal domain of the chaperone ClpA. {ECO 0000255|HAMAP-Rule MF_00302, ECO 0000269|PubMed 12235156, ECO 0000269|PubMed 12426582}. # SUPFAM SSF54736 SSF54736 # eggNOG COG2127 LUCA # eggNOG ENOG4105KAE Bacteria BLAST swissprot:CLPS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CLPS_ECOLI BioCyc ECOL316407:JW0865-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0865-MONOMER BioCyc EcoCyc:G6463-MONOMER http://biocyc.org/getid?id=EcoCyc:G6463-MONOMER COG COG2127 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2127 DIP DIP-35408N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35408N DOI 10.1016/S1097-2765(02)00485-9 http://dx.doi.org/10.1016/S1097-2765(02)00485-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb869 http://dx.doi.org/10.1038/nsb869 DOI 10.1074/jbc.M208104200 http://dx.doi.org/10.1074/jbc.M208104200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3992 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3992 EcoGene EG14241 http://www.ecogene.org/geneInfo.php?eg_id=EG14241 EnsemblBacteria AAC73968 http://www.ensemblgenomes.org/id/AAC73968 EnsemblBacteria AAC73968 http://www.ensemblgenomes.org/id/AAC73968 EnsemblBacteria BAA35600 http://www.ensemblgenomes.org/id/BAA35600 EnsemblBacteria BAA35600 http://www.ensemblgenomes.org/id/BAA35600 EnsemblBacteria BAA35600 http://www.ensemblgenomes.org/id/BAA35600 EnsemblBacteria b0881 http://www.ensemblgenomes.org/id/b0881 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0051087 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051087 GO_process GO:0006508 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006508 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GO_process GO:0030163 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030163 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 3.30.1390.10 http://www.cathdb.info/version/latest/superfamily/3.30.1390.10 GeneID 948443 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948443 HAMAP MF_00302 http://hamap.expasy.org/unirule/MF_00302 HOGENOM HOG000247049 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000247049&db=HOGENOM6 InParanoid P0A8Q6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8Q6 IntAct P0A8Q6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8Q6* InterPro IPR003769 http://www.ebi.ac.uk/interpro/entry/IPR003769 InterPro IPR014719 http://www.ebi.ac.uk/interpro/entry/IPR014719 InterPro IPR022935 http://www.ebi.ac.uk/interpro/entry/IPR022935 KEGG_Gene ecj:JW0865 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0865 KEGG_Gene eco:b0881 http://www.genome.jp/dbget-bin/www_bget?eco:b0881 KEGG_Orthology KO:K06891 http://www.genome.jp/dbget-bin/www_bget?KO:K06891 MINT MINT-365090 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-365090 OMA RDWLDFD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RDWLDFD PDB 1LZW http://www.ebi.ac.uk/pdbe-srv/view/entry/1LZW PDB 1MBU http://www.ebi.ac.uk/pdbe-srv/view/entry/1MBU PDB 1MBV http://www.ebi.ac.uk/pdbe-srv/view/entry/1MBV PDB 1MBX http://www.ebi.ac.uk/pdbe-srv/view/entry/1MBX PDB 1MG9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1MG9 PDB 1R6O http://www.ebi.ac.uk/pdbe-srv/view/entry/1R6O PDB 1R6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/1R6Q PDB 2W9R http://www.ebi.ac.uk/pdbe-srv/view/entry/2W9R PDB 2WA8 http://www.ebi.ac.uk/pdbe-srv/view/entry/2WA8 PDB 2WA9 http://www.ebi.ac.uk/pdbe-srv/view/entry/2WA9 PDB 3O1F http://www.ebi.ac.uk/pdbe-srv/view/entry/3O1F PDB 3O2B http://www.ebi.ac.uk/pdbe-srv/view/entry/3O2B PDB 3O2H http://www.ebi.ac.uk/pdbe-srv/view/entry/3O2H PDB 3O2O http://www.ebi.ac.uk/pdbe-srv/view/entry/3O2O PDBsum 1LZW http://www.ebi.ac.uk/pdbsum/1LZW PDBsum 1MBU http://www.ebi.ac.uk/pdbsum/1MBU PDBsum 1MBV http://www.ebi.ac.uk/pdbsum/1MBV PDBsum 1MBX http://www.ebi.ac.uk/pdbsum/1MBX PDBsum 1MG9 http://www.ebi.ac.uk/pdbsum/1MG9 PDBsum 1R6O http://www.ebi.ac.uk/pdbsum/1R6O PDBsum 1R6Q http://www.ebi.ac.uk/pdbsum/1R6Q PDBsum 2W9R http://www.ebi.ac.uk/pdbsum/2W9R PDBsum 2WA8 http://www.ebi.ac.uk/pdbsum/2WA8 PDBsum 2WA9 http://www.ebi.ac.uk/pdbsum/2WA9 PDBsum 3O1F http://www.ebi.ac.uk/pdbsum/3O1F PDBsum 3O2B http://www.ebi.ac.uk/pdbsum/3O2B PDBsum 3O2H http://www.ebi.ac.uk/pdbsum/3O2H PDBsum 3O2O http://www.ebi.ac.uk/pdbsum/3O2O PSORT swissprot:CLPS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CLPS_ECOLI PSORT-B swissprot:CLPS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CLPS_ECOLI PSORT2 swissprot:CLPS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CLPS_ECOLI Pfam PF02617 http://pfam.xfam.org/family/PF02617 Phobius swissprot:CLPS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CLPS_ECOLI PhylomeDB P0A8Q6 http://phylomedb.org/?seqid=P0A8Q6 ProteinModelPortal P0A8Q6 http://www.proteinmodelportal.org/query/uniprot/P0A8Q6 PubMed 11931773 http://www.ncbi.nlm.nih.gov/pubmed/11931773 PubMed 12235156 http://www.ncbi.nlm.nih.gov/pubmed/12235156 PubMed 12426582 http://www.ncbi.nlm.nih.gov/pubmed/12426582 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415402 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415402 RefSeq WP_000520781 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000520781 SMR P0A8Q6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8Q6 STRING 511145.b0881 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0881&targetmode=cogs STRING COG2127 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2127&targetmode=cogs SUPFAM SSF54736 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54736 SWISS-2DPAGE P0A8Q6 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A8Q6 UniProtKB CLPS_ECOLI http://www.uniprot.org/uniprot/CLPS_ECOLI UniProtKB-AC P0A8Q6 http://www.uniprot.org/uniprot/P0A8Q6 charge swissprot:CLPS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CLPS_ECOLI eggNOG COG2127 http://eggnogapi.embl.de/nog_data/html/tree/COG2127 eggNOG ENOG4105KAE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KAE epestfind swissprot:CLPS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CLPS_ECOLI garnier swissprot:CLPS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CLPS_ECOLI helixturnhelix swissprot:CLPS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CLPS_ECOLI hmoment swissprot:CLPS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CLPS_ECOLI iep swissprot:CLPS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CLPS_ECOLI inforesidue swissprot:CLPS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CLPS_ECOLI octanol swissprot:CLPS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CLPS_ECOLI pepcoil swissprot:CLPS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CLPS_ECOLI pepdigest swissprot:CLPS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CLPS_ECOLI pepinfo swissprot:CLPS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CLPS_ECOLI pepnet swissprot:CLPS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CLPS_ECOLI pepstats swissprot:CLPS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CLPS_ECOLI pepwheel swissprot:CLPS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CLPS_ECOLI pepwindow swissprot:CLPS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CLPS_ECOLI sigcleave swissprot:CLPS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CLPS_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES SFGH2_ECOLI Kinetic parameters KM=0.43 mM for S-formylglutathione {ECO 0000269|PubMed 16567800}; KM=1.03 mM for alpha-naphthyl acetate {ECO 0000269|PubMed 16567800}; KM=0.45 mM for pNP-acetate {ECO 0000269|PubMed 16567800}; KM=0.70 mM for pNP-butyrate {ECO 0000269|PubMed 16567800}; KM=0.95 mM for pNP-caproate {ECO 0000269|PubMed 16567800}; KM=0.48 mM for pNP-propionate {ECO 0000269|PubMed 16567800}; KM=0.58 mM for S-lactoylglutathione {ECO 0000269|PubMed 16567800}; Vmax=12.6 umol/min/mg enzyme with S-formylglutathione as substrate {ECO 0000269|PubMed 16567800}; Vmax=9.79 umol/min/mg enzyme with alpha-naphthyl acetate as substrate {ECO 0000269|PubMed 16567800}; Vmax=0.50 umol/min/mg enzyme with pNP-acetate as substrate {ECO 0000269|PubMed 16567800}; Vmax=0.70 umol/min/mg enzyme with pNP-butyrate as substrate {ECO 0000269|PubMed 16567800}; Vmax=0.64 umol/min/mg enzyme with pNP-caproate as substrate {ECO 0000269|PubMed 16567800}; Vmax=0.71 umol/min/mg enzyme with pNP-propionate as substrate {ECO 0000269|PubMed 16567800}; Vmax=1.97 umol/min/mg enzyme with S-lactoylglutathione as substrate {ECO 0000269|PubMed 16567800}; # BRENDA 3.1.2 2026 # BioGrid 4260472 8 # CATALYTIC ACTIVITY S-formylglutathione + H(2)O = glutathione + formate. {ECO:0000269|PubMed 16567800}. # ENZYME REGULATION Inhibited by the sulfhydryl inhibitors (N- ethylmaleimide, iodoacetate, ZnCl(2) and CuCl(2)). {ECO:0000269|PubMed 16567800}. # ESTHER ecoli-yeiG A85-EsteraseD-FGH # EcoGene EG12026 yeiG # FUNCTION SFGH2_ECOLI Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate. Shows also esterase activity against alpha-naphthyl acetate, lactoylglutathione, palmitoyl-CoA and several pNP-esters of short chain fatty acids. {ECO 0000269|PubMed 15808744, ECO 0000269|PubMed 16567800}. # GO_function GO:0004416 hydroxyacylglutathione hydrolase activity; IDA:EcoCyc. # GO_function GO:0018738 S-formylglutathione hydrolase activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0052689 carboxylic ester hydrolase activity; IEA:UniProtKB-KW. # GO_process GO:0046294 formaldehyde catabolic process; IMP:EcoCyc. # GO_process GO:0051289 protein homotetramerization; IDA:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.1820 -; 1. # INDUCTION Constitutively expressed. {ECO:0000269|PubMed 16567800}. # IntAct P33018 5 # InterPro IPR000801 Esterase_put # InterPro IPR014186 S-formylglutathione_hydrol # InterPro IPR029058 AB_hydrolase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00680 Methane metabolism # Organism SFGH2_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10061 PTHR10061 # PATRIC 32119655 VBIEscCol129921_2238 # PIR A64984 A64984 # Pfam PF00756 Esterase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SFGH2_ECOLI S-formylglutathione hydrolase YeiG # RefSeq NP_416659 NC_000913.3 # RefSeq WP_000425438 NZ_LN832404.1 # SIMILARITY Belongs to the esterase D family. {ECO 0000305}. # SUBUNIT Homotetramer. {ECO:0000269|PubMed 16567800}. # SUPFAM SSF53474 SSF53474 # TIGRFAMs TIGR02821 fghA_ester_D # eggNOG COG0627 LUCA # eggNOG ENOG4105C4W Bacteria BLAST swissprot:SFGH2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SFGH2_ECOLI BioCyc ECOL316407:JW2141-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2141-MONOMER BioCyc EcoCyc:EG12026-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12026-MONOMER BioCyc MetaCyc:EG12026-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12026-MONOMER COG COG0627 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0627 DIP DIP-11919N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11919N DOI 10.1016/j.fmrre.2004.12.006 http://dx.doi.org/10.1016/j.fmrre.2004.12.006 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M600996200 http://dx.doi.org/10.1074/jbc.M600996200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.2.12 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.2.12 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.2.12 http://enzyme.expasy.org/EC/3.1.2.12 EchoBASE EB1961 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1961 EcoGene EG12026 http://www.ecogene.org/geneInfo.php?eg_id=EG12026 EnsemblBacteria AAC75215 http://www.ensemblgenomes.org/id/AAC75215 EnsemblBacteria AAC75215 http://www.ensemblgenomes.org/id/AAC75215 EnsemblBacteria BAE76631 http://www.ensemblgenomes.org/id/BAE76631 EnsemblBacteria BAE76631 http://www.ensemblgenomes.org/id/BAE76631 EnsemblBacteria BAE76631 http://www.ensemblgenomes.org/id/BAE76631 EnsemblBacteria b2154 http://www.ensemblgenomes.org/id/b2154 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004416 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004416 GO_function GO:0018738 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018738 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0052689 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052689 GO_process GO:0046294 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046294 GO_process GO:0051289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051289 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.1820 http://www.cathdb.info/version/latest/superfamily/3.40.50.1820 GeneID 949045 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949045 HOGENOM HOG000263929 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000263929&db=HOGENOM6 InParanoid P33018 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33018 IntAct P33018 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33018* IntEnz 3.1.2.12 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.2.12 InterPro IPR000801 http://www.ebi.ac.uk/interpro/entry/IPR000801 InterPro IPR014186 http://www.ebi.ac.uk/interpro/entry/IPR014186 InterPro IPR029058 http://www.ebi.ac.uk/interpro/entry/IPR029058 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2141 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2141 KEGG_Gene eco:b2154 http://www.genome.jp/dbget-bin/www_bget?eco:b2154 KEGG_Orthology KO:K01070 http://www.genome.jp/dbget-bin/www_bget?KO:K01070 KEGG_Pathway ko00680 http://www.genome.jp/kegg-bin/show_pathway?ko00680 KEGG_Reaction rn:R00527 http://www.genome.jp/dbget-bin/www_bget?rn:R00527 OMA HIKHHAK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HIKHHAK PANTHER PTHR10061 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10061 PSORT swissprot:SFGH2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SFGH2_ECOLI PSORT-B swissprot:SFGH2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SFGH2_ECOLI PSORT2 swissprot:SFGH2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SFGH2_ECOLI Pfam PF00756 http://pfam.xfam.org/family/PF00756 Phobius swissprot:SFGH2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SFGH2_ECOLI PhylomeDB P33018 http://phylomedb.org/?seqid=P33018 ProteinModelPortal P33018 http://www.proteinmodelportal.org/query/uniprot/P33018 PubMed 15808744 http://www.ncbi.nlm.nih.gov/pubmed/15808744 PubMed 16567800 http://www.ncbi.nlm.nih.gov/pubmed/16567800 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416659 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416659 RefSeq WP_000425438 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000425438 SMR P33018 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33018 STRING 511145.b2154 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2154&targetmode=cogs STRING COG0627 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0627&targetmode=cogs SUPFAM SSF53474 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53474 TIGRFAMs TIGR02821 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02821 UniProtKB SFGH2_ECOLI http://www.uniprot.org/uniprot/SFGH2_ECOLI UniProtKB-AC P33018 http://www.uniprot.org/uniprot/P33018 charge swissprot:SFGH2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SFGH2_ECOLI eggNOG COG0627 http://eggnogapi.embl.de/nog_data/html/tree/COG0627 eggNOG ENOG4105C4W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C4W epestfind swissprot:SFGH2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SFGH2_ECOLI garnier swissprot:SFGH2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SFGH2_ECOLI helixturnhelix swissprot:SFGH2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SFGH2_ECOLI hmoment swissprot:SFGH2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SFGH2_ECOLI iep swissprot:SFGH2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SFGH2_ECOLI inforesidue swissprot:SFGH2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SFGH2_ECOLI octanol swissprot:SFGH2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SFGH2_ECOLI pepcoil swissprot:SFGH2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SFGH2_ECOLI pepdigest swissprot:SFGH2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SFGH2_ECOLI pepinfo swissprot:SFGH2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SFGH2_ECOLI pepnet swissprot:SFGH2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SFGH2_ECOLI pepstats swissprot:SFGH2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SFGH2_ECOLI pepwheel swissprot:SFGH2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SFGH2_ECOLI pepwindow swissprot:SFGH2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SFGH2_ECOLI sigcleave swissprot:SFGH2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SFGH2_ECOLI ## Database ID URL or Descriptions # BioGrid 4261623 17 # EcoGene EG13294 yaiL # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # IntAct P51024 4 # InterPro IPR018636 DUF2058 # Organism YAIL_ECOLI Escherichia coli (strain K12) # PATRIC 32115845 VBIEscCol129921_0364 # PIR B64763 B64763 # Pfam PF09831 DUF2058 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAIL_ECOLI Uncharacterized protein YaiL # RefSeq NP_414888 NC_000913.3 # RefSeq WP_001096705 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18078.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=D85613; Type=Frameshift; Positions=6; Evidence={ECO 0000305}; # eggNOG COG3122 LUCA # eggNOG ENOG4105IUQ Bacteria BLAST swissprot:YAIL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAIL_ECOLI BioCyc ECOL316407:JW0345-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0345-MONOMER BioCyc EcoCyc:G6207-MONOMER http://biocyc.org/getid?id=EcoCyc:G6207-MONOMER COG COG3122 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3122 DIP DIP-11273N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11273N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D85613 http://www.ebi.ac.uk/ena/data/view/D85613 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB3079 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3079 EcoGene EG13294 http://www.ecogene.org/geneInfo.php?eg_id=EG13294 EnsemblBacteria AAC73457 http://www.ensemblgenomes.org/id/AAC73457 EnsemblBacteria AAC73457 http://www.ensemblgenomes.org/id/AAC73457 EnsemblBacteria BAE76136 http://www.ensemblgenomes.org/id/BAE76136 EnsemblBacteria BAE76136 http://www.ensemblgenomes.org/id/BAE76136 EnsemblBacteria BAE76136 http://www.ensemblgenomes.org/id/BAE76136 EnsemblBacteria b0354 http://www.ensemblgenomes.org/id/b0354 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GeneID 944993 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944993 HOGENOM HOG000291627 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000291627&db=HOGENOM6 InParanoid P51024 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P51024 IntAct P51024 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P51024* InterPro IPR018636 http://www.ebi.ac.uk/interpro/entry/IPR018636 KEGG_Gene ecj:JW0345 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0345 KEGG_Gene eco:b0354 http://www.genome.jp/dbget-bin/www_bget?eco:b0354 KEGG_Orthology KO:K09912 http://www.genome.jp/dbget-bin/www_bget?KO:K09912 MINT MINT-1246572 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1246572 OMA EMNRITV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EMNRITV PSORT swissprot:YAIL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAIL_ECOLI PSORT-B swissprot:YAIL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAIL_ECOLI PSORT2 swissprot:YAIL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAIL_ECOLI Pfam PF09831 http://pfam.xfam.org/family/PF09831 Phobius swissprot:YAIL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAIL_ECOLI ProteinModelPortal P51024 http://www.proteinmodelportal.org/query/uniprot/P51024 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414888 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414888 RefSeq WP_001096705 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001096705 STRING 511145.b0354 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0354&targetmode=cogs STRING COG3122 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3122&targetmode=cogs UniProtKB YAIL_ECOLI http://www.uniprot.org/uniprot/YAIL_ECOLI UniProtKB-AC P51024 http://www.uniprot.org/uniprot/P51024 charge swissprot:YAIL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAIL_ECOLI eggNOG COG3122 http://eggnogapi.embl.de/nog_data/html/tree/COG3122 eggNOG ENOG4105IUQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105IUQ epestfind swissprot:YAIL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAIL_ECOLI garnier swissprot:YAIL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAIL_ECOLI helixturnhelix swissprot:YAIL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAIL_ECOLI hmoment swissprot:YAIL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAIL_ECOLI iep swissprot:YAIL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAIL_ECOLI inforesidue swissprot:YAIL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAIL_ECOLI octanol swissprot:YAIL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAIL_ECOLI pepcoil swissprot:YAIL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAIL_ECOLI pepdigest swissprot:YAIL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAIL_ECOLI pepinfo swissprot:YAIL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAIL_ECOLI pepnet swissprot:YAIL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAIL_ECOLI pepstats swissprot:YAIL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAIL_ECOLI pepwheel swissprot:YAIL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAIL_ECOLI pepwindow swissprot:YAIL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAIL_ECOLI sigcleave swissprot:YAIL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAIL_ECOLI ## Database ID URL or Descriptions # BioGrid 4260298 10 # EcoGene EG13980 ydiU # HAMAP MF_00692 UPF0061 # IntAct P77649 7 # InterPro IPR003846 UPF0061 # Organism YDIU_ECOLI Escherichia coli (strain K12) # PATRIC 32118718 VBIEscCol129921_1777 # PIR B64929 B64929 # Pfam PF02696 UPF0061 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDIU_ECOLI UPF0061 protein YdiU # RefSeq NP_416221 NC_000913.3 # RefSeq WP_000175703 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0061 (SELO) family. {ECO 0000305}. # eggNOG COG0397 LUCA # eggNOG ENOG4105CNG Bacteria BLAST swissprot:YDIU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDIU_ECOLI BioCyc ECOL316407:JW1696-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1696-MONOMER BioCyc EcoCyc:G6924-MONOMER http://biocyc.org/getid?id=EcoCyc:G6924-MONOMER COG COG0397 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0397 DIP DIP-11762N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11762N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3737 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3737 EcoGene EG13980 http://www.ecogene.org/geneInfo.php?eg_id=EG13980 EnsemblBacteria AAC74776 http://www.ensemblgenomes.org/id/AAC74776 EnsemblBacteria AAC74776 http://www.ensemblgenomes.org/id/AAC74776 EnsemblBacteria BAA15475 http://www.ensemblgenomes.org/id/BAA15475 EnsemblBacteria BAA15475 http://www.ensemblgenomes.org/id/BAA15475 EnsemblBacteria BAA15475 http://www.ensemblgenomes.org/id/BAA15475 EnsemblBacteria b1706 http://www.ensemblgenomes.org/id/b1706 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946219 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946219 HAMAP MF_00692 http://hamap.expasy.org/unirule/MF_00692 HOGENOM HOG000008335 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000008335&db=HOGENOM6 InParanoid P77649 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77649 IntAct P77649 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77649* InterPro IPR003846 http://www.ebi.ac.uk/interpro/entry/IPR003846 KEGG_Gene ecj:JW1696 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1696 KEGG_Gene eco:b1706 http://www.genome.jp/dbget-bin/www_bget?eco:b1706 KEGG_Orthology KO:K08997 http://www.genome.jp/dbget-bin/www_bget?KO:K08997 OMA QAYGFCH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QAYGFCH PSORT swissprot:YDIU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDIU_ECOLI PSORT-B swissprot:YDIU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDIU_ECOLI PSORT2 swissprot:YDIU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDIU_ECOLI Pfam PF02696 http://pfam.xfam.org/family/PF02696 Phobius swissprot:YDIU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDIU_ECOLI PhylomeDB P77649 http://phylomedb.org/?seqid=P77649 ProteinModelPortal P77649 http://www.proteinmodelportal.org/query/uniprot/P77649 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416221 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416221 RefSeq WP_000175703 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000175703 STRING 511145.b1706 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1706&targetmode=cogs STRING COG0397 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0397&targetmode=cogs UniProtKB YDIU_ECOLI http://www.uniprot.org/uniprot/YDIU_ECOLI UniProtKB-AC P77649 http://www.uniprot.org/uniprot/P77649 charge swissprot:YDIU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDIU_ECOLI eggNOG COG0397 http://eggnogapi.embl.de/nog_data/html/tree/COG0397 eggNOG ENOG4105CNG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CNG epestfind swissprot:YDIU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDIU_ECOLI garnier swissprot:YDIU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDIU_ECOLI helixturnhelix swissprot:YDIU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDIU_ECOLI hmoment swissprot:YDIU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDIU_ECOLI iep swissprot:YDIU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDIU_ECOLI inforesidue swissprot:YDIU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDIU_ECOLI octanol swissprot:YDIU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDIU_ECOLI pepcoil swissprot:YDIU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDIU_ECOLI pepdigest swissprot:YDIU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDIU_ECOLI pepinfo swissprot:YDIU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDIU_ECOLI pepnet swissprot:YDIU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDIU_ECOLI pepstats swissprot:YDIU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDIU_ECOLI pepwheel swissprot:YDIU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDIU_ECOLI pepwindow swissprot:YDIU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDIU_ECOLI sigcleave swissprot:YDIU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDIU_ECOLI ## Database ID URL or Descriptions # BioGrid 4261007 10 # CDD cd07377 WHTH_GntR # EcoGene EG20249 uxuR # FUNCTION UXUR_ECOLI Repressor for the uxuRBA operon. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEP:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # Gene3D 1.20.120.530 -; 1. # IntAct P39161 2 # InterPro IPR000524 Tscrpt_reg_HTH_GntR # InterPro IPR008920 TF_FadR/GntR_C # InterPro IPR011711 GntR_C # InterPro IPR011991 WHTH_DNA-bd_dom # KEGG_Brite ko03000 Transcription factors # Organism UXUR_ECOLI Escherichia coli (strain K12) # PATRIC 32124246 VBIEscCol129921_4466 # PIR S56549 S56549 # PRINTS PR00035 HTHGNTR # PROSITE PS50949 HTH_GNTR # Pfam PF00392 GntR # Pfam PF07729 FCD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UXUR_ECOLI Uxu operon transcriptional regulator # RefSeq NP_418744 NC_000913.3 # RefSeq WP_000833679 NZ_LN832404.1 # SIMILARITY Contains 1 HTH gntR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00307}. # SMART SM00345 HTH_GNTR # SMART SM00895 FCD # SUPFAM SSF46785 SSF46785 # SUPFAM SSF48008 SSF48008 # eggNOG COG2186 LUCA # eggNOG ENOG4105C6F Bacteria BLAST swissprot:UXUR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UXUR_ECOLI BioCyc ECOL316407:JW4287-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4287-MONOMER BioCyc EcoCyc:EG20249-MONOMER http://biocyc.org/getid?id=EcoCyc:EG20249-MONOMER COG COG2186 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2186 DIP DIP-11110N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11110N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D13329 http://www.ebi.ac.uk/ena/data/view/D13329 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB4151 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4151 EcoGene EG20249 http://www.ecogene.org/geneInfo.php?eg_id=EG20249 EnsemblBacteria AAC77280 http://www.ensemblgenomes.org/id/AAC77280 EnsemblBacteria AAC77280 http://www.ensemblgenomes.org/id/AAC77280 EnsemblBacteria BAE78317 http://www.ensemblgenomes.org/id/BAE78317 EnsemblBacteria BAE78317 http://www.ensemblgenomes.org/id/BAE78317 EnsemblBacteria BAE78317 http://www.ensemblgenomes.org/id/BAE78317 EnsemblBacteria b4324 http://www.ensemblgenomes.org/id/b4324 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 1.20.120.530 http://www.cathdb.info/version/latest/superfamily/1.20.120.530 GeneID 948849 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948849 HOGENOM HOG000273991 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000273991&db=HOGENOM6 InParanoid P39161 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39161 IntAct P39161 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39161* InterPro IPR000524 http://www.ebi.ac.uk/interpro/entry/IPR000524 InterPro IPR008920 http://www.ebi.ac.uk/interpro/entry/IPR008920 InterPro IPR011711 http://www.ebi.ac.uk/interpro/entry/IPR011711 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW4287 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4287 KEGG_Gene eco:b4324 http://www.genome.jp/dbget-bin/www_bget?eco:b4324 KEGG_Orthology KO:K13637 http://www.genome.jp/dbget-bin/www_bget?KO:K13637 OMA NSESGDM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NSESGDM PRINTS PR00035 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00035 PROSITE PS50949 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50949 PSORT swissprot:UXUR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UXUR_ECOLI PSORT-B swissprot:UXUR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UXUR_ECOLI PSORT2 swissprot:UXUR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UXUR_ECOLI Pfam PF00392 http://pfam.xfam.org/family/PF00392 Pfam PF07729 http://pfam.xfam.org/family/PF07729 Phobius swissprot:UXUR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UXUR_ECOLI PhylomeDB P39161 http://phylomedb.org/?seqid=P39161 ProteinModelPortal P39161 http://www.proteinmodelportal.org/query/uniprot/P39161 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418744 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418744 RefSeq WP_000833679 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000833679 SMART SM00345 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00345 SMART SM00895 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00895 SMR P39161 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39161 STRING 511145.b4324 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4324&targetmode=cogs STRING COG2186 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2186&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SUPFAM SSF48008 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48008 UniProtKB UXUR_ECOLI http://www.uniprot.org/uniprot/UXUR_ECOLI UniProtKB-AC P39161 http://www.uniprot.org/uniprot/P39161 charge swissprot:UXUR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UXUR_ECOLI eggNOG COG2186 http://eggnogapi.embl.de/nog_data/html/tree/COG2186 eggNOG ENOG4105C6F http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C6F epestfind swissprot:UXUR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UXUR_ECOLI garnier swissprot:UXUR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UXUR_ECOLI helixturnhelix swissprot:UXUR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UXUR_ECOLI hmoment swissprot:UXUR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UXUR_ECOLI iep swissprot:UXUR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UXUR_ECOLI inforesidue swissprot:UXUR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UXUR_ECOLI octanol swissprot:UXUR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UXUR_ECOLI pepcoil swissprot:UXUR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UXUR_ECOLI pepdigest swissprot:UXUR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UXUR_ECOLI pepinfo swissprot:UXUR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UXUR_ECOLI pepnet swissprot:UXUR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UXUR_ECOLI pepstats swissprot:UXUR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UXUR_ECOLI pepwheel swissprot:UXUR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UXUR_ECOLI pepwindow swissprot:UXUR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UXUR_ECOLI sigcleave swissprot:UXUR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UXUR_ECOLI ## Database ID URL or Descriptions # BioGrid 4260291 261 # CATALYTIC ACTIVITY YDIO_ECOLI Acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor. # COFACTOR Name=FAD; Xref=ChEBI:CHEBI 57692; Evidence={ECO:0000250}; # EcoGene EG13974 ydiO # GO_function GO:0000062 fatty-acyl-CoA binding; IBA:GO_Central. # GO_function GO:0003995 acyl-CoA dehydrogenase activity; IBA:GO_Central. # GO_function GO:0009055 electron carrier activity; IBA:GO_Central. # GO_function GO:0050660 flavin adenine dinucleotide binding; IBA:GO_Central. # GO_function GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor; IMP:EcoCyc. # GO_process GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase; IBA:GO_Central. # GO_process GO:0055088 lipid homeostasis; IBA:GO_Central. # GO_process GO:0071271 1-butanol biosynthetic process; IMP:CACAO. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0042592 homeostatic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.540.10 -; 1. # InterPro IPR006089 Acyl-CoA_DH_CS # InterPro IPR006091 Acyl-CoA_Oxase/DH_cen-dom # InterPro IPR009075 AcylCo_DH/oxidase_C # InterPro IPR009100 AcylCoA_DH/oxidase_NM_dom # InterPro IPR013786 AcylCoA_DH/ox_N # Organism YDIO_ECOLI Escherichia coli (strain K12) # PATRIC 32118696 VBIEscCol129921_1766 # PIR G64927 G64927 # PROSITE PS00072 ACYL_COA_DH_1 # PROSITE PS00073 ACYL_COA_DH_2 # Pfam PF00441 Acyl-CoA_dh_1 # Pfam PF02770 Acyl-CoA_dh_M # Pfam PF02771 Acyl-CoA_dh_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDIO_ECOLI Probable acyl-CoA dehydrogenase YdiO # RefSeq NP_416210 NC_000913.3 # RefSeq WP_000347850 NZ_LN832404.1 # SIMILARITY Belongs to the acyl-CoA dehydrogenase family. {ECO 0000305}. # SUPFAM SSF47203 SSF47203 # SUPFAM SSF56645 SSF56645 # eggNOG COG1960 LUCA # eggNOG ENOG4105C1G Bacteria BLAST swissprot:YDIO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDIO_ECOLI BioCyc ECOL316407:JW5275-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5275-MONOMER BioCyc EcoCyc:G6918-MONOMER http://biocyc.org/getid?id=EcoCyc:G6918-MONOMER BioCyc MetaCyc:G6918-MONOMER http://biocyc.org/getid?id=MetaCyc:G6918-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.3.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.3.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.3.-.- http://enzyme.expasy.org/EC/1.3.-.- EchoBASE EB3731 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3731 EcoGene EG13974 http://www.ecogene.org/geneInfo.php?eg_id=EG13974 EnsemblBacteria AAC74765 http://www.ensemblgenomes.org/id/AAC74765 EnsemblBacteria AAC74765 http://www.ensemblgenomes.org/id/AAC74765 EnsemblBacteria BAA15464 http://www.ensemblgenomes.org/id/BAA15464 EnsemblBacteria BAA15464 http://www.ensemblgenomes.org/id/BAA15464 EnsemblBacteria BAA15464 http://www.ensemblgenomes.org/id/BAA15464 EnsemblBacteria b1695 http://www.ensemblgenomes.org/id/b1695 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000062 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000062 GO_function GO:0003995 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003995 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_function GO:0052890 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052890 GO_process GO:0033539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033539 GO_process GO:0055088 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055088 GO_process GO:0071271 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071271 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.540.10 http://www.cathdb.info/version/latest/superfamily/1.10.540.10 GeneID 945626 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945626 HOGENOM HOG000131659 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000131659&db=HOGENOM6 InParanoid P0A9U8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9U8 IntEnz 1.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.3 InterPro IPR006089 http://www.ebi.ac.uk/interpro/entry/IPR006089 InterPro IPR006091 http://www.ebi.ac.uk/interpro/entry/IPR006091 InterPro IPR009075 http://www.ebi.ac.uk/interpro/entry/IPR009075 InterPro IPR009100 http://www.ebi.ac.uk/interpro/entry/IPR009100 InterPro IPR013786 http://www.ebi.ac.uk/interpro/entry/IPR013786 KEGG_Gene ecj:JW5275 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5275 KEGG_Gene eco:b1695 http://www.genome.jp/dbget-bin/www_bget?eco:b1695 OMA FEKAFQY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FEKAFQY PROSITE PS00072 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00072 PROSITE PS00073 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00073 PSORT swissprot:YDIO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDIO_ECOLI PSORT-B swissprot:YDIO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDIO_ECOLI PSORT2 swissprot:YDIO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDIO_ECOLI Pfam PF00441 http://pfam.xfam.org/family/PF00441 Pfam PF02770 http://pfam.xfam.org/family/PF02770 Pfam PF02771 http://pfam.xfam.org/family/PF02771 Phobius swissprot:YDIO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDIO_ECOLI PhylomeDB P0A9U8 http://phylomedb.org/?seqid=P0A9U8 ProteinModelPortal P0A9U8 http://www.proteinmodelportal.org/query/uniprot/P0A9U8 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416210 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416210 RefSeq WP_000347850 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000347850 SMR P0A9U8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9U8 STRING 511145.b1695 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1695&targetmode=cogs SUPFAM SSF47203 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47203 SUPFAM SSF56645 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56645 UniProtKB YDIO_ECOLI http://www.uniprot.org/uniprot/YDIO_ECOLI UniProtKB-AC P0A9U8 http://www.uniprot.org/uniprot/P0A9U8 charge swissprot:YDIO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDIO_ECOLI eggNOG COG1960 http://eggnogapi.embl.de/nog_data/html/tree/COG1960 eggNOG ENOG4105C1G http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C1G epestfind swissprot:YDIO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDIO_ECOLI garnier swissprot:YDIO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDIO_ECOLI helixturnhelix swissprot:YDIO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDIO_ECOLI hmoment swissprot:YDIO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDIO_ECOLI iep swissprot:YDIO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDIO_ECOLI inforesidue swissprot:YDIO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDIO_ECOLI octanol swissprot:YDIO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDIO_ECOLI pepcoil swissprot:YDIO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDIO_ECOLI pepdigest swissprot:YDIO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDIO_ECOLI pepinfo swissprot:YDIO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDIO_ECOLI pepnet swissprot:YDIO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDIO_ECOLI pepstats swissprot:YDIO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDIO_ECOLI pepwheel swissprot:YDIO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDIO_ECOLI pepwindow swissprot:YDIO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDIO_ECOLI sigcleave swissprot:YDIO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDIO_ECOLI ## Database ID URL or Descriptions # BioGrid 4259449 24 # CDD cd06261 TM_PBP2 # EcoGene EG10772 proW # FUNCTION PROW_ECOLI Part of the ProU ABC transporter complex involved in glycine betaine and proline betaine uptake (PubMed 3305496, PubMed 7898450, PubMed 23249124). Probably responsible for the translocation of the substrate across the membrane (Probable). {ECO 0000269|PubMed 23249124, ECO 0000269|PubMed 3305496, ECO 0000269|PubMed 7898450, ECO 0000305}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005215 transporter activity; IDA:EcoCyc. # GO_process GO:0006865 amino acid transport; IEA:UniProtKB-KW. # GO_process GO:0015871 choline transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006810 transport # Gene3D 1.10.3720.10 -; 1. # INTERACTION PROW_ECOLI P14175 proV; NbExp=2; IntAct=EBI-8794761, EBI-546797; # InterPro IPR000515 MetI-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00208 Glycine betaine/proline transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism PROW_ECOLI Escherichia coli (strain K12) # PATRIC 32120746 VBIEscCol129921_2770 # PIR JS0129 MMECPW # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Glycine betaine/proline betaine transport system permease protein ProW {ECO 0000305} # RefSeq NP_417164 NC_000913.3 # RefSeq WP_000774988 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION PROW_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255}. # SUBUNIT The complex is composed of two ATP-binding proteins (ProV), two transmembrane proteins (ProW) and a solute-binding protein (ProX). {ECO:0000269|PubMed 23249124}. # SUPFAM SSF161098 SSF161098 # TCDB 3.A.1.12 the atp-binding cassette (abc) superfamily # eggNOG COG4176 LUCA # eggNOG ENOG4108HQS Bacteria BLAST swissprot:PROW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PROW_ECOLI BioCyc ECOL316407:JW2653-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2653-MONOMER BioCyc EcoCyc:PROW-MONOMER http://biocyc.org/getid?id=EcoCyc:PROW-MONOMER BioCyc MetaCyc:PROW-MONOMER http://biocyc.org/getid?id=MetaCyc:PROW-MONOMER COG COG4176 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4176 DOI 10.1007/BF00290728 http://dx.doi.org/10.1007/BF00290728 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.3109/09687688.2012.754060 http://dx.doi.org/10.3109/09687688.2012.754060 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M24856 http://www.ebi.ac.uk/ena/data/view/M24856 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0765 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0765 EcoGene EG10772 http://www.ecogene.org/geneInfo.php?eg_id=EG10772 EnsemblBacteria AAC75725 http://www.ensemblgenomes.org/id/AAC75725 EnsemblBacteria AAC75725 http://www.ensemblgenomes.org/id/AAC75725 EnsemblBacteria BAA16543 http://www.ensemblgenomes.org/id/BAA16543 EnsemblBacteria BAA16543 http://www.ensemblgenomes.org/id/BAA16543 EnsemblBacteria BAA16543 http://www.ensemblgenomes.org/id/BAA16543 EnsemblBacteria b2678 http://www.ensemblgenomes.org/id/b2678 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_process GO:0006865 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865 GO_process GO:0015871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015871 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 947145 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947145 HOGENOM HOG000279300 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000279300&db=HOGENOM6 InParanoid P14176 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P14176 IntAct P14176 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P14176* InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2653 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2653 KEGG_Gene eco:b2678 http://www.genome.jp/dbget-bin/www_bget?eco:b2678 KEGG_Orthology KO:K02001 http://www.genome.jp/dbget-bin/www_bget?KO:K02001 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA HFNIMDP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HFNIMDP PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:PROW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PROW_ECOLI PSORT-B swissprot:PROW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PROW_ECOLI PSORT2 swissprot:PROW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PROW_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Phobius swissprot:PROW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PROW_ECOLI PhylomeDB P14176 http://phylomedb.org/?seqid=P14176 ProteinModelPortal P14176 http://www.proteinmodelportal.org/query/uniprot/P14176 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 23249124 http://www.ncbi.nlm.nih.gov/pubmed/23249124 PubMed 2649479 http://www.ncbi.nlm.nih.gov/pubmed/2649479 PubMed 3305496 http://www.ncbi.nlm.nih.gov/pubmed/3305496 PubMed 7898450 http://www.ncbi.nlm.nih.gov/pubmed/7898450 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417164 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417164 RefSeq WP_000774988 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000774988 STRING 511145.b2678 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2678&targetmode=cogs STRING COG4176 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4176&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.12 http://www.tcdb.org/search/result.php?tc=3.A.1.12 UniProtKB PROW_ECOLI http://www.uniprot.org/uniprot/PROW_ECOLI UniProtKB-AC P14176 http://www.uniprot.org/uniprot/P14176 charge swissprot:PROW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PROW_ECOLI eggNOG COG4176 http://eggnogapi.embl.de/nog_data/html/tree/COG4176 eggNOG ENOG4108HQS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108HQS epestfind swissprot:PROW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PROW_ECOLI garnier swissprot:PROW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PROW_ECOLI helixturnhelix swissprot:PROW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PROW_ECOLI hmoment swissprot:PROW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PROW_ECOLI iep swissprot:PROW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PROW_ECOLI inforesidue swissprot:PROW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PROW_ECOLI octanol swissprot:PROW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PROW_ECOLI pepcoil swissprot:PROW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PROW_ECOLI pepdigest swissprot:PROW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PROW_ECOLI pepinfo swissprot:PROW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PROW_ECOLI pepnet swissprot:PROW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PROW_ECOLI pepstats swissprot:PROW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PROW_ECOLI pepwheel swissprot:PROW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PROW_ECOLI pepwindow swissprot:PROW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PROW_ECOLI sigcleave swissprot:PROW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PROW_ECOLI ## Database ID URL or Descriptions # AltName DLHH_ECOLI Dienelactone hydrolase # BioGrid 4259478 9 # CATALYTIC ACTIVITY DLHH_ECOLI 4-carboxymethylenebut-2-en-4-olide + H(2)O = 4-oxohex-2-enedioate. # ESTHER ecoli-dlhh Dienelactone_hydrolase # EcoGene EG14321 ysgA # GO_function GO:0008806 carboxymethylenebutenolidase activity; IEA:UniProtKB-EC. # GOslim_function GO:0003674 molecular_function # Gene3D 3.40.50.1820 -; 1. # InterPro IPR002925 Dienelactn_hydro # InterPro IPR029058 AB_hydrolase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00361 Chlorocyclohexane and chlorobenzene degradation # KEGG_Pathway ko00364 Fluorobenzoate degradation # KEGG_Pathway ko00623 Toluene degradation # Organism DLHH_ECOLI Escherichia coli (strain K12) # PATRIC 32123161 VBIEscCol129921_3946 # Pfam PF01738 DLH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DLHH_ECOLI Putative carboxymethylenebutenolidase # RefSeq WP_001336442 NZ_LN832404.1 # RefSeq YP_026268 NC_000913.3 # SIMILARITY Belongs to the dienelactone hydrolase family. {ECO 0000305}. # SUPFAM SSF53474 SSF53474 # eggNOG COG0412 LUCA # eggNOG ENOG4105CDZ Bacteria BLAST swissprot:DLHH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DLHH_ECOLI BioCyc ECOL316407:JW5853-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5853-MONOMER BioCyc EcoCyc:G7804-MONOMER http://biocyc.org/getid?id=EcoCyc:G7804-MONOMER COG COG0412 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0412 DIP DIP-12929N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12929N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.1.45 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.1.45 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.1.45 http://enzyme.expasy.org/EC/3.1.1.45 EchoBASE EB4067 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4067 EcoGene EG14321 http://www.ecogene.org/geneInfo.php?eg_id=EG14321 EnsemblBacteria AAT48226 http://www.ensemblgenomes.org/id/AAT48226 EnsemblBacteria AAT48226 http://www.ensemblgenomes.org/id/AAT48226 EnsemblBacteria BAE77471 http://www.ensemblgenomes.org/id/BAE77471 EnsemblBacteria BAE77471 http://www.ensemblgenomes.org/id/BAE77471 EnsemblBacteria BAE77471 http://www.ensemblgenomes.org/id/BAE77471 EnsemblBacteria b3830 http://www.ensemblgenomes.org/id/b3830 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008806 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008806 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 Gene3D 3.40.50.1820 http://www.cathdb.info/version/latest/superfamily/3.40.50.1820 GeneID 948320 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948320 HOGENOM HOG000157123 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000157123&db=HOGENOM6 InParanoid P56262 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P56262 IntEnz 3.1.1.45 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.1.45 InterPro IPR002925 http://www.ebi.ac.uk/interpro/entry/IPR002925 InterPro IPR029058 http://www.ebi.ac.uk/interpro/entry/IPR029058 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5853 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5853 KEGG_Gene eco:b3830 http://www.genome.jp/dbget-bin/www_bget?eco:b3830 KEGG_Orthology KO:K01061 http://www.genome.jp/dbget-bin/www_bget?KO:K01061 KEGG_Pathway ko00361 http://www.genome.jp/kegg-bin/show_pathway?ko00361 KEGG_Pathway ko00364 http://www.genome.jp/kegg-bin/show_pathway?ko00364 KEGG_Pathway ko00623 http://www.genome.jp/kegg-bin/show_pathway?ko00623 KEGG_Reaction rn:R03893 http://www.genome.jp/dbget-bin/www_bget?rn:R03893 KEGG_Reaction rn:R05510 http://www.genome.jp/dbget-bin/www_bget?rn:R05510 KEGG_Reaction rn:R05511 http://www.genome.jp/dbget-bin/www_bget?rn:R05511 KEGG_Reaction rn:R06835 http://www.genome.jp/dbget-bin/www_bget?rn:R06835 KEGG_Reaction rn:R06838 http://www.genome.jp/dbget-bin/www_bget?rn:R06838 KEGG_Reaction rn:R08120 http://www.genome.jp/dbget-bin/www_bget?rn:R08120 KEGG_Reaction rn:R08121 http://www.genome.jp/dbget-bin/www_bget?rn:R08121 KEGG_Reaction rn:R09136 http://www.genome.jp/dbget-bin/www_bget?rn:R09136 KEGG_Reaction rn:R09220 http://www.genome.jp/dbget-bin/www_bget?rn:R09220 KEGG_Reaction rn:R09222 http://www.genome.jp/dbget-bin/www_bget?rn:R09222 OMA CWGGRIS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CWGGRIS PSORT swissprot:DLHH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DLHH_ECOLI PSORT-B swissprot:DLHH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DLHH_ECOLI PSORT2 swissprot:DLHH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DLHH_ECOLI Pfam PF01738 http://pfam.xfam.org/family/PF01738 Phobius swissprot:DLHH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DLHH_ECOLI PhylomeDB P56262 http://phylomedb.org/?seqid=P56262 ProteinModelPortal P56262 http://www.proteinmodelportal.org/query/uniprot/P56262 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001336442 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001336442 RefSeq YP_026268 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026268 SMR P56262 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P56262 STRING 511145.b3830 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3830&targetmode=cogs STRING COG0412 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0412&targetmode=cogs SUPFAM SSF53474 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53474 UniProtKB DLHH_ECOLI http://www.uniprot.org/uniprot/DLHH_ECOLI UniProtKB-AC P56262 http://www.uniprot.org/uniprot/P56262 charge swissprot:DLHH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DLHH_ECOLI eggNOG COG0412 http://eggnogapi.embl.de/nog_data/html/tree/COG0412 eggNOG ENOG4105CDZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CDZ epestfind swissprot:DLHH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DLHH_ECOLI garnier swissprot:DLHH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DLHH_ECOLI helixturnhelix swissprot:DLHH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DLHH_ECOLI hmoment swissprot:DLHH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DLHH_ECOLI iep swissprot:DLHH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DLHH_ECOLI inforesidue swissprot:DLHH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DLHH_ECOLI octanol swissprot:DLHH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DLHH_ECOLI pepcoil swissprot:DLHH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DLHH_ECOLI pepdigest swissprot:DLHH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DLHH_ECOLI pepinfo swissprot:DLHH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DLHH_ECOLI pepnet swissprot:DLHH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DLHH_ECOLI pepstats swissprot:DLHH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DLHH_ECOLI pepwheel swissprot:DLHH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DLHH_ECOLI pepwindow swissprot:DLHH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DLHH_ECOLI sigcleave swissprot:DLHH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DLHH_ECOLI ## Database ID URL or Descriptions # AltName SLYD_ECOLI Histidine-rich protein # AltName SLYD_ECOLI Metallochaperone SlyD # AltName SLYD_ECOLI Rotamase # AltName SLYD_ECOLI Sensitivity to lysis protein D # AltName SLYD_ECOLI WHP # BioGrid 4260682 10 # CATALYTIC ACTIVITY Peptidylproline (omega=180) = peptidylproline (omega=0). {ECO:0000269|PubMed 16388577}. # DISRUPTION PHENOTYPE Cells undergo an apoptotic-like death upon DNA damage characterized by membrane depolarization. {ECO:0000269|PubMed 22412352}. # DOMAIN SLYD_ECOLI The C-terminal region binds up to 7 nickel ions in a non- cooperative manner. Can also bind zinc with high affinity, and copper or cobalt with lower affinity. No binding detectable for ferrous, ferric, magnesium and calcium ions. Binding of nickel causes conformational rearrangements in the PPIase domain, modulating its isomerase activity. This region is also important for hydrogenase biosynthesis. # DOMAIN SLYD_ECOLI The N-terminal region consists of two globular folded domains that contain prolyl isomerase and chaperone activities. # ENZYME REGULATION SLYD_ECOLI PPIase activity is inhibited by binding of nickel ions to the C-terminal metal-binding region and/or the C- terminal part of the PPIase domain. Folding activity is inhibited by FK506 and by permanently unfolded proteins, irrespective of their proline content. {ECO 0000269|PubMed 16388577, ECO 0000269|PubMed 9188461}. # EcoGene EG11663 slyD # FUNCTION SLYD_ECOLI Also involved in hydrogenase metallocenter assembly, probably by participating in the nickel insertion step. This function in hydrogenase biosynthesis requires chaperone activity and the presence of the metal-binding domain, but not PPIase activity. # FUNCTION SLYD_ECOLI Folding helper with both chaperone and peptidyl-prolyl cis-trans isomerase (PPIase) activities. Chaperone activity prevents aggregation of unfolded or partially folded proteins and promotes their correct folding. PPIases catalyze the cis-trans isomerization of Xaa-Pro bonds of peptides, which accelerates slow steps of protein folding and thus shortens the lifetime of intermediates. Both strategies lower the concentration of intermediates and increase the productivity and yield of the folding reaction. SlyD could be involved in Tat-dependent translocation, by binding to the Tat-type signal of folded proteins. The PPIase substrate specificity, carried out with synthetic peptides of the 'suc-Ala-Xaa-Pro-Phe-4NA' type (where Xaa is the AA tested), was found to be Phe > Ala > Leu. # FUNCTION SLYD_ECOLI Required for lysis of phiX174 infected cells by stabilizing the hydrophobic viral lysis protein E and allowing it to accumulate to the levels required to exert its lytic effect. May act by a chaperone-like mechanism. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003755 peptidyl-prolyl cis-trans isomerase activity; IDA:EcoCyc. # GO_function GO:0005507 copper ion binding; IDA:EcoCyc. # GO_function GO:0005528 FK506 binding; IBA:GO_Central. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_function GO:0016151 nickel cation binding; IDA:EcoCyc. # GO_function GO:0050897 cobalt ion binding; IDA:EcoCyc. # GO_function GO:0051082 unfolded protein binding; IDA:EcoCyc. # GO_process GO:0009408 response to heat; IEP:EcoliWiki. # GO_process GO:0022417 protein maturation by protein folding; IMP:EcoliWiki. # GO_process GO:0042026 protein refolding; IDA:EcoCyc. # GO_process GO:0050821 protein stabilization; IMP:EcoliWiki. # GO_process GO:0051604 protein maturation; IMP:EcoCyc. # GO_process GO:0061077 chaperone-mediated protein folding; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_function GO:0051082 unfolded protein binding # GOslim_process GO:0006457 protein folding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0051604 protein maturation # INTERACTION SLYD_ECOLI P16431 hycE; NbExp=7; IntAct=EBI-369251, EBI-552702; P0AAN3 hypB; NbExp=4; IntAct=EBI-369251, EBI-558261; # IntAct P0A9K9 119 # InterPro IPR001179 PPIase_FKBP_dom # InterPro IPR023566 PPIase_FKBP # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03110 Chaperones and folding catalysts # MISCELLANEOUS SLYD_ECOLI The activity of SlyD is considerably smaller than the one found in other PPIases with the same substrate. # Organism SLYD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10516 PTHR10516; 2 # PATRIC 32122130 VBIEscCol129921_3442 # PDB 2K8I NMR; -; A=1-165 # PDB 2KFW NMR; -; A=1-196 # PIR A49987 A49987 # PROSITE PS50059 FKBP_PPIASE # Pfam PF00254 FKBP_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SLYD_ECOLI FKBP-type peptidyl-prolyl cis-trans isomerase SlyD # RefSeq NP_417808 NC_000913.3 # RefSeq WP_000861334 NZ_LN832404.1 # SIMILARITY Belongs to the FKBP-type PPIase family. {ECO 0000305}. # SIMILARITY Contains 1 PPIase FKBP-type domain. {ECO:0000255|PROSITE-ProRule PRU00277}. # SUBCELLULAR LOCATION SLYD_ECOLI Cytoplasm. # SUBUNIT SLYD_ECOLI Monomer. Binds to a broad range of unrelated Tat signal sequences. Interacts with the hydrogenase nickel incorporation protein HypB. {ECO 0000269|PubMed 15569666, ECO 0000269|PubMed 17215254, ECO 0000269|PubMed 19947632}. # eggNOG COG1047 LUCA # eggNOG ENOG4108YZY Bacteria BLAST swissprot:SLYD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SLYD_ECOLI BioCyc ECOL316407:JW3311-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3311-MONOMER BioCyc EcoCyc:EG11663-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11663-MONOMER BioCyc MetaCyc:EG11663-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11663-MONOMER COG COG1047 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1047 DIP DIP-31853N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31853N DOI 10.1007/BF00404209 http://dx.doi.org/10.1007/BF00404209 DOI 10.1016/j.jmb.2009.01.034 http://dx.doi.org/10.1016/j.jmb.2009.01.034 DOI 10.1021/bi051922n http://dx.doi.org/10.1021/bi051922n DOI 10.1021/ja9081765 http://dx.doi.org/10.1021/ja9081765 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2002.02984.x http://dx.doi.org/10.1046/j.1365-2958.2002.02984.x DOI 10.1074/jbc.272.25.15697 http://dx.doi.org/10.1074/jbc.272.25.15697 DOI 10.1074/jbc.M411799200 http://dx.doi.org/10.1074/jbc.M411799200 DOI 10.1074/jbc.M608235200 http://dx.doi.org/10.1074/jbc.M608235200 DOI 10.1111/j.1742-4658.2009.07159.x http://dx.doi.org/10.1111/j.1742-4658.2009.07159.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00922-07 http://dx.doi.org/10.1128/JB.00922-07 DOI 10.1371/journal.pbio.1001281 http://dx.doi.org/10.1371/journal.pbio.1001281 EC_number EC:5.2.1.8 http://www.genome.jp/dbget-bin/www_bget?EC:5.2.1.8 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L13261 http://www.ebi.ac.uk/ena/data/view/L13261 EMBL L28082 http://www.ebi.ac.uk/ena/data/view/L28082 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL Z21496 http://www.ebi.ac.uk/ena/data/view/Z21496 ENZYME 5.2.1.8 http://enzyme.expasy.org/EC/5.2.1.8 EchoBASE EB1614 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1614 EcoGene EG11663 http://www.ecogene.org/geneInfo.php?eg_id=EG11663 EnsemblBacteria AAC76374 http://www.ensemblgenomes.org/id/AAC76374 EnsemblBacteria AAC76374 http://www.ensemblgenomes.org/id/AAC76374 EnsemblBacteria BAE77942 http://www.ensemblgenomes.org/id/BAE77942 EnsemblBacteria BAE77942 http://www.ensemblgenomes.org/id/BAE77942 EnsemblBacteria BAE77942 http://www.ensemblgenomes.org/id/BAE77942 EnsemblBacteria b3349 http://www.ensemblgenomes.org/id/b3349 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003755 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003755 GO_function GO:0005507 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005507 GO_function GO:0005528 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005528 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0016151 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016151 GO_function GO:0050897 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050897 GO_function GO:0051082 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051082 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GO_process GO:0022417 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022417 GO_process GO:0042026 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042026 GO_process GO:0050821 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050821 GO_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 GO_process GO:0061077 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061077 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_function GO:0051082 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051082 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 GeneID 947859 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947859 HOGENOM HOG000154889 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000154889&db=HOGENOM6 InParanoid P0A9K9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9K9 IntAct P0A9K9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9K9* IntEnz 5.2.1.8 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.2.1.8 InterPro IPR001179 http://www.ebi.ac.uk/interpro/entry/IPR001179 InterPro IPR023566 http://www.ebi.ac.uk/interpro/entry/IPR023566 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW3311 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3311 KEGG_Gene eco:b3349 http://www.genome.jp/dbget-bin/www_bget?eco:b3349 KEGG_Orthology KO:K03775 http://www.genome.jp/dbget-bin/www_bget?KO:K03775 MINT MINT-1223693 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1223693 OMA PKDVFVG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PKDVFVG PANTHER PTHR10516 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10516 PDB 2K8I http://www.ebi.ac.uk/pdbe-srv/view/entry/2K8I PDB 2KFW http://www.ebi.ac.uk/pdbe-srv/view/entry/2KFW PDBsum 2K8I http://www.ebi.ac.uk/pdbsum/2K8I PDBsum 2KFW http://www.ebi.ac.uk/pdbsum/2KFW PROSITE PS50059 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50059 PSORT swissprot:SLYD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SLYD_ECOLI PSORT-B swissprot:SLYD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SLYD_ECOLI PSORT2 swissprot:SLYD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SLYD_ECOLI Pfam PF00254 http://pfam.xfam.org/family/PF00254 Phobius swissprot:SLYD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SLYD_ECOLI PhylomeDB P0A9K9 http://phylomedb.org/?seqid=P0A9K9 ProteinModelPortal P0A9K9 http://www.proteinmodelportal.org/query/uniprot/P0A9K9 PubMed 12100551 http://www.ncbi.nlm.nih.gov/pubmed/12100551 PubMed 15569666 http://www.ncbi.nlm.nih.gov/pubmed/15569666 PubMed 16388577 http://www.ncbi.nlm.nih.gov/pubmed/16388577 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17215254 http://www.ncbi.nlm.nih.gov/pubmed/17215254 PubMed 17720786 http://www.ncbi.nlm.nih.gov/pubmed/17720786 PubMed 19356587 http://www.ncbi.nlm.nih.gov/pubmed/19356587 PubMed 19645725 http://www.ncbi.nlm.nih.gov/pubmed/19645725 PubMed 19947632 http://www.ncbi.nlm.nih.gov/pubmed/19947632 PubMed 22412352 http://www.ncbi.nlm.nih.gov/pubmed/22412352 PubMed 7540828 http://www.ncbi.nlm.nih.gov/pubmed/7540828 PubMed 8300624 http://www.ncbi.nlm.nih.gov/pubmed/8300624 PubMed 8300625 http://www.ncbi.nlm.nih.gov/pubmed/8300625 PubMed 9188461 http://www.ncbi.nlm.nih.gov/pubmed/9188461 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417808 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417808 RefSeq WP_000861334 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000861334 SMR P0A9K9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9K9 STRING 511145.b3349 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3349&targetmode=cogs STRING COG1047 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1047&targetmode=cogs UniProtKB SLYD_ECOLI http://www.uniprot.org/uniprot/SLYD_ECOLI UniProtKB-AC P0A9K9 http://www.uniprot.org/uniprot/P0A9K9 charge swissprot:SLYD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SLYD_ECOLI eggNOG COG1047 http://eggnogapi.embl.de/nog_data/html/tree/COG1047 eggNOG ENOG4108YZY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108YZY epestfind swissprot:SLYD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SLYD_ECOLI garnier swissprot:SLYD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SLYD_ECOLI helixturnhelix swissprot:SLYD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SLYD_ECOLI hmoment swissprot:SLYD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SLYD_ECOLI iep swissprot:SLYD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SLYD_ECOLI inforesidue swissprot:SLYD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SLYD_ECOLI octanol swissprot:SLYD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SLYD_ECOLI pepcoil swissprot:SLYD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SLYD_ECOLI pepdigest swissprot:SLYD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SLYD_ECOLI pepinfo swissprot:SLYD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SLYD_ECOLI pepnet swissprot:SLYD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SLYD_ECOLI pepstats swissprot:SLYD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SLYD_ECOLI pepwheel swissprot:SLYD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SLYD_ECOLI pepwindow swissprot:SLYD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SLYD_ECOLI sigcleave swissprot:SLYD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SLYD_ECOLI ## Database ID URL or Descriptions # BioGrid 4262108 11 # EcoGene EG14055 yegL # Gene3D 3.40.50.410 -; 1. # IntAct P76396 12 # InterPro IPR002035 VWF_A # InterPro IPR011392 Tellurite-R_TerY # Organism YEGL_ECOLI Escherichia coli (strain K12) # PATRIC 32119479 VBIEscCol129921_2150 # PIR H64973 H64973 # PIRSF PIRSF020634 TerY_vWA # PROSITE PS50234 VWFA # Pfam PF00092 VWA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEGL_ECOLI Uncharacterized protein YegL # RefSeq NP_416577 NC_000913.3 # RefSeq WP_000003154 NZ_LN832404.1 # SIMILARITY Contains 1 VWFA domain. {ECO:0000255|PROSITE- ProRule PRU00219}. # SMART SM00327 VWA # SUPFAM SSF53300 SSF53300 # eggNOG COG4245 LUCA # eggNOG ENOG4108M24 Bacteria BLAST swissprot:YEGL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEGL_ECOLI BioCyc ECOL316407:JW2058-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2058-MONOMER BioCyc EcoCyc:G7112-MONOMER http://biocyc.org/getid?id=EcoCyc:G7112-MONOMER DIP DIP-11882N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11882N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3808 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3808 EcoGene EG14055 http://www.ecogene.org/geneInfo.php?eg_id=EG14055 EnsemblBacteria AAC75134 http://www.ensemblgenomes.org/id/AAC75134 EnsemblBacteria AAC75134 http://www.ensemblgenomes.org/id/AAC75134 EnsemblBacteria BAE76580 http://www.ensemblgenomes.org/id/BAE76580 EnsemblBacteria BAE76580 http://www.ensemblgenomes.org/id/BAE76580 EnsemblBacteria BAE76580 http://www.ensemblgenomes.org/id/BAE76580 EnsemblBacteria b2073 http://www.ensemblgenomes.org/id/b2073 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.40.50.410 http://www.cathdb.info/version/latest/superfamily/3.40.50.410 GeneID 946602 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946602 HOGENOM HOG000122042 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122042&db=HOGENOM6 IntAct P76396 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76396* InterPro IPR002035 http://www.ebi.ac.uk/interpro/entry/IPR002035 InterPro IPR011392 http://www.ebi.ac.uk/interpro/entry/IPR011392 KEGG_Gene ecj:JW2058 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2058 KEGG_Gene eco:b2073 http://www.genome.jp/dbget-bin/www_bget?eco:b2073 OMA ENPEQRC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ENPEQRC PROSITE PS50234 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50234 PSORT swissprot:YEGL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEGL_ECOLI PSORT-B swissprot:YEGL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEGL_ECOLI PSORT2 swissprot:YEGL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEGL_ECOLI Pfam PF00092 http://pfam.xfam.org/family/PF00092 Phobius swissprot:YEGL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEGL_ECOLI ProteinModelPortal P76396 http://www.proteinmodelportal.org/query/uniprot/P76396 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416577 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416577 RefSeq WP_000003154 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000003154 SMART SM00327 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00327 SMR P76396 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76396 STRING 511145.b2073 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2073&targetmode=cogs SUPFAM SSF53300 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53300 UniProtKB YEGL_ECOLI http://www.uniprot.org/uniprot/YEGL_ECOLI UniProtKB-AC P76396 http://www.uniprot.org/uniprot/P76396 charge swissprot:YEGL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEGL_ECOLI eggNOG COG4245 http://eggnogapi.embl.de/nog_data/html/tree/COG4245 eggNOG ENOG4108M24 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108M24 epestfind swissprot:YEGL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEGL_ECOLI garnier swissprot:YEGL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEGL_ECOLI helixturnhelix swissprot:YEGL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEGL_ECOLI hmoment swissprot:YEGL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEGL_ECOLI iep swissprot:YEGL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEGL_ECOLI inforesidue swissprot:YEGL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEGL_ECOLI octanol swissprot:YEGL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEGL_ECOLI pepcoil swissprot:YEGL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEGL_ECOLI pepdigest swissprot:YEGL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEGL_ECOLI pepinfo swissprot:YEGL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEGL_ECOLI pepnet swissprot:YEGL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEGL_ECOLI pepstats swissprot:YEGL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEGL_ECOLI pepwheel swissprot:YEGL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEGL_ECOLI pepwindow swissprot:YEGL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEGL_ECOLI sigcleave swissprot:YEGL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEGL_ECOLI ## Database ID URL or Descriptions # BioGrid 4263493 9 # EcoGene EG11750 yhgA # InterPro IPR006842 Transposase_31 # InterPro IPR010106 CHP01784 # Organism YHGA_ECOLI Escherichia coli (strain K12) # PATRIC 32122258 VBIEscCol129921_3506 # PIR F65136 F65136 # Pfam PF04754 Transposase_31 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHGA_ECOLI Uncharacterized protein YhgA # RefSeq NP_417870 NC_000913.3 # RefSeq WP_000039062 NZ_LN832404.1 # SIMILARITY Belongs to the YadD/YfaD/YhgA/YjiP family. {ECO 0000305}. # TIGRFAMs TIGR01784 T_den_put_tspse # eggNOG COG5464 LUCA # eggNOG ENOG4105DNE Bacteria BLAST swissprot:YHGA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHGA_ECOLI BioCyc ECOL316407:JW3374-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3374-MONOMER BioCyc EcoCyc:EG11750-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11750-MONOMER DIP DIP-12335N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12335N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/17.19.8004 http://dx.doi.org/10.1093/nar/17.19.8004 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X15587 http://www.ebi.ac.uk/ena/data/view/X15587 EchoBASE EB1700 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1700 EcoGene EG11750 http://www.ecogene.org/geneInfo.php?eg_id=EG11750 EnsemblBacteria AAC76436 http://www.ensemblgenomes.org/id/AAC76436 EnsemblBacteria AAC76436 http://www.ensemblgenomes.org/id/AAC76436 EnsemblBacteria BAE77880 http://www.ensemblgenomes.org/id/BAE77880 EnsemblBacteria BAE77880 http://www.ensemblgenomes.org/id/BAE77880 EnsemblBacteria BAE77880 http://www.ensemblgenomes.org/id/BAE77880 EnsemblBacteria b3411 http://www.ensemblgenomes.org/id/b3411 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947917 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947917 HOGENOM HOG000116866 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000116866&db=HOGENOM6 InParanoid P31667 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31667 IntAct P31667 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31667* InterPro IPR006842 http://www.ebi.ac.uk/interpro/entry/IPR006842 InterPro IPR010106 http://www.ebi.ac.uk/interpro/entry/IPR010106 KEGG_Gene ecj:JW3374 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3374 KEGG_Gene eco:b3411 http://www.genome.jp/dbget-bin/www_bget?eco:b3411 MINT MINT-1248711 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1248711 OMA IENQSTH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IENQSTH PSORT swissprot:YHGA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHGA_ECOLI PSORT-B swissprot:YHGA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHGA_ECOLI PSORT2 swissprot:YHGA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHGA_ECOLI Pfam PF04754 http://pfam.xfam.org/family/PF04754 Phobius swissprot:YHGA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHGA_ECOLI PhylomeDB P31667 http://phylomedb.org/?seqid=P31667 ProteinModelPortal P31667 http://www.proteinmodelportal.org/query/uniprot/P31667 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2678009 http://www.ncbi.nlm.nih.gov/pubmed/2678009 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417870 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417870 RefSeq WP_000039062 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000039062 STRING 511145.b3411 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3411&targetmode=cogs TIGRFAMs TIGR01784 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01784 UniProtKB YHGA_ECOLI http://www.uniprot.org/uniprot/YHGA_ECOLI UniProtKB-AC P31667 http://www.uniprot.org/uniprot/P31667 charge swissprot:YHGA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHGA_ECOLI eggNOG COG5464 http://eggnogapi.embl.de/nog_data/html/tree/COG5464 eggNOG ENOG4105DNE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DNE epestfind swissprot:YHGA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHGA_ECOLI garnier swissprot:YHGA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHGA_ECOLI helixturnhelix swissprot:YHGA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHGA_ECOLI hmoment swissprot:YHGA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHGA_ECOLI iep swissprot:YHGA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHGA_ECOLI inforesidue swissprot:YHGA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHGA_ECOLI octanol swissprot:YHGA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHGA_ECOLI pepcoil swissprot:YHGA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHGA_ECOLI pepdigest swissprot:YHGA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHGA_ECOLI pepinfo swissprot:YHGA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHGA_ECOLI pepnet swissprot:YHGA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHGA_ECOLI pepstats swissprot:YHGA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHGA_ECOLI pepwheel swissprot:YHGA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHGA_ECOLI pepwindow swissprot:YHGA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHGA_ECOLI sigcleave swissprot:YHGA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHGA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259954 15 # EcoGene EG12421 ybiI # GO_function GO:0008270 zinc ion binding; IEA:InterPro. # GOslim_function GO:0043167 ion binding # IntAct P41039 13 # InterPro IPR000962 Znf_DskA_TraR # InterPro IPR020458 Znf_DskA_TraR_CS # InterPro IPR020460 Znf_C4-type_bac # Organism YBII_ECOLI Escherichia coli (strain K12) # PATRIC 32116809 VBIEscCol129921_0830 # PDB 2KGO NMR; -; A=1-88 # PIR C64817 C64817 # PRINTS PR00618 DKSAZNFINGER # PROSITE PS01102 ZF_DKSA_1 # PROSITE PS51128 ZF_DKSA_2 # Pfam PF01258 zf-dskA_traR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBII_ECOLI Uncharacterized protein YbiI # RefSeq NP_415324 NC_000913.3 # RefSeq WP_000146343 NZ_LN832404.1 # SIMILARITY Contains 1 dksA C4-type zinc finger. {ECO:0000255|PROSITE-ProRule PRU00510}. # eggNOG COG1734 LUCA # eggNOG ENOG4105KSC Bacteria BLAST swissprot:YBII_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBII_ECOLI BioCyc ECOL316407:JW0788-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0788-MONOMER BioCyc EcoCyc:EG12421-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12421-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1266/jjg.69.1 http://dx.doi.org/10.1266/jjg.69.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L02123 http://www.ebi.ac.uk/ena/data/view/L02123 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2320 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2320 EcoGene EG12421 http://www.ecogene.org/geneInfo.php?eg_id=EG12421 EnsemblBacteria AAC73890 http://www.ensemblgenomes.org/id/AAC73890 EnsemblBacteria AAC73890 http://www.ensemblgenomes.org/id/AAC73890 EnsemblBacteria BAA35469 http://www.ensemblgenomes.org/id/BAA35469 EnsemblBacteria BAA35469 http://www.ensemblgenomes.org/id/BAA35469 EnsemblBacteria BAA35469 http://www.ensemblgenomes.org/id/BAA35469 EnsemblBacteria b0803 http://www.ensemblgenomes.org/id/b0803 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GeneID 945434 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945434 HOGENOM HOG000141757 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000141757&db=HOGENOM6 InParanoid P41039 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P41039 IntAct P41039 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P41039* InterPro IPR000962 http://www.ebi.ac.uk/interpro/entry/IPR000962 InterPro IPR020458 http://www.ebi.ac.uk/interpro/entry/IPR020458 InterPro IPR020460 http://www.ebi.ac.uk/interpro/entry/IPR020460 KEGG_Gene ecj:JW0788 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0788 KEGG_Gene eco:b0803 http://www.genome.jp/dbget-bin/www_bget?eco:b0803 OMA MAGGWAR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MAGGWAR PDB 2KGO http://www.ebi.ac.uk/pdbe-srv/view/entry/2KGO PDBsum 2KGO http://www.ebi.ac.uk/pdbsum/2KGO PRINTS PR00618 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00618 PROSITE PS01102 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01102 PROSITE PS51128 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51128 PSORT swissprot:YBII_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBII_ECOLI PSORT-B swissprot:YBII_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBII_ECOLI PSORT2 swissprot:YBII_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBII_ECOLI Pfam PF01258 http://pfam.xfam.org/family/PF01258 Phobius swissprot:YBII_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBII_ECOLI PhylomeDB P41039 http://phylomedb.org/?seqid=P41039 ProteinModelPortal P41039 http://www.proteinmodelportal.org/query/uniprot/P41039 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8037924 http://www.ncbi.nlm.nih.gov/pubmed/8037924 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415324 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415324 RefSeq WP_000146343 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000146343 SMR P41039 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P41039 STRING 511145.b0803 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0803&targetmode=cogs UniProtKB YBII_ECOLI http://www.uniprot.org/uniprot/YBII_ECOLI UniProtKB-AC P41039 http://www.uniprot.org/uniprot/P41039 charge swissprot:YBII_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBII_ECOLI eggNOG COG1734 http://eggnogapi.embl.de/nog_data/html/tree/COG1734 eggNOG ENOG4105KSC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KSC epestfind swissprot:YBII_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBII_ECOLI garnier swissprot:YBII_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBII_ECOLI helixturnhelix swissprot:YBII_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBII_ECOLI hmoment swissprot:YBII_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBII_ECOLI iep swissprot:YBII_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBII_ECOLI inforesidue swissprot:YBII_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBII_ECOLI octanol swissprot:YBII_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBII_ECOLI pepcoil swissprot:YBII_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBII_ECOLI pepdigest swissprot:YBII_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBII_ECOLI pepinfo swissprot:YBII_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBII_ECOLI pepnet swissprot:YBII_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBII_ECOLI pepstats swissprot:YBII_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBII_ECOLI pepwheel swissprot:YBII_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBII_ECOLI pepwindow swissprot:YBII_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBII_ECOLI sigcleave swissprot:YBII_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBII_ECOLI ## Database ID URL or Descriptions # BioGrid 4260884 4 # CDD cd01949 GGDEF # EcoGene EG13814 yneF # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:1902021 regulation of bacterial-type flagellum-dependent cell motility; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0008150 biological_process # InterPro IPR000160 GGDEF_dom # InterPro IPR029787 Nucleotide_cyclase # Organism YNEF_ECOLI Escherichia coli (strain K12) # PATRIC 32118342 VBIEscCol129921_1591 # PIR E64906 E64906 # PROSITE PS50887 GGDEF # Pfam PF00990 GGDEF # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNEF_ECOLI Uncharacterized protein YneF # RefSeq NP_416039 NC_000913.3 # RefSeq WP_000878968 NZ_LN832404.1 # SIMILARITY Contains 1 GGDEF domain. {ECO:0000255|PROSITE- ProRule PRU00095}. # SMART SM00267 GGDEF # SUBCELLULAR LOCATION YNEF_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # SUPFAM SSF55073 SSF55073 # TIGRFAMs TIGR00254 GGDEF # eggNOG ENOG4105BZU Bacteria # eggNOG ENOG410XNMH LUCA BLAST swissprot:YNEF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNEF_ECOLI BioCyc ECOL316407:JW5825-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5825-MONOMER BioCyc EcoCyc:G6808-MONOMER http://biocyc.org/getid?id=EcoCyc:G6808-MONOMER DIP DIP-47997N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47997N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3575 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3575 EcoGene EG13814 http://www.ecogene.org/geneInfo.php?eg_id=EG13814 EnsemblBacteria AAC74595 http://www.ensemblgenomes.org/id/AAC74595 EnsemblBacteria AAC74595 http://www.ensemblgenomes.org/id/AAC74595 EnsemblBacteria BAA15205 http://www.ensemblgenomes.org/id/BAA15205 EnsemblBacteria BAA15205 http://www.ensemblgenomes.org/id/BAA15205 EnsemblBacteria BAA15205 http://www.ensemblgenomes.org/id/BAA15205 EnsemblBacteria b1522 http://www.ensemblgenomes.org/id/b1522 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:1902021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 947422 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947422 HOGENOM HOG000120740 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120740&db=HOGENOM6 InParanoid P76147 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76147 InterPro IPR000160 http://www.ebi.ac.uk/interpro/entry/IPR000160 InterPro IPR029787 http://www.ebi.ac.uk/interpro/entry/IPR029787 KEGG_Gene ecj:JW5825 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5825 KEGG_Gene eco:b1522 http://www.genome.jp/dbget-bin/www_bget?eco:b1522 OMA ATWLAWF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ATWLAWF PROSITE PS50887 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50887 PSORT swissprot:YNEF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNEF_ECOLI PSORT-B swissprot:YNEF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNEF_ECOLI PSORT2 swissprot:YNEF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNEF_ECOLI Pfam PF00990 http://pfam.xfam.org/family/PF00990 Phobius swissprot:YNEF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNEF_ECOLI PhylomeDB P76147 http://phylomedb.org/?seqid=P76147 ProteinModelPortal P76147 http://www.proteinmodelportal.org/query/uniprot/P76147 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416039 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416039 RefSeq WP_000878968 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000878968 SMART SM00267 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00267 SMR P76147 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76147 STRING 511145.b1522 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1522&targetmode=cogs SUPFAM SSF55073 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55073 TIGRFAMs TIGR00254 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00254 UniProtKB YNEF_ECOLI http://www.uniprot.org/uniprot/YNEF_ECOLI UniProtKB-AC P76147 http://www.uniprot.org/uniprot/P76147 charge swissprot:YNEF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNEF_ECOLI eggNOG ENOG4105BZU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZU eggNOG ENOG410XNMH http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNMH epestfind swissprot:YNEF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNEF_ECOLI garnier swissprot:YNEF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNEF_ECOLI helixturnhelix swissprot:YNEF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNEF_ECOLI hmoment swissprot:YNEF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNEF_ECOLI iep swissprot:YNEF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNEF_ECOLI inforesidue swissprot:YNEF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNEF_ECOLI octanol swissprot:YNEF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNEF_ECOLI pepcoil swissprot:YNEF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNEF_ECOLI pepdigest swissprot:YNEF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNEF_ECOLI pepinfo swissprot:YNEF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNEF_ECOLI pepnet swissprot:YNEF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNEF_ECOLI pepstats swissprot:YNEF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNEF_ECOLI pepwheel swissprot:YNEF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNEF_ECOLI pepwindow swissprot:YNEF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNEF_ECOLI sigcleave swissprot:YNEF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNEF_ECOLI ## Database ID URL or Descriptions # BioGrid 4261802 6 # EcoGene EG12531 yjgL # IntAct P39336 8 # Organism YJGL_ECOLI Escherichia coli (strain K12) # PATRIC 32124077 VBIEscCol129921_4383 # PIR S56478 S56478 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJGL_ECOLI Uncharacterized protein YjgL # RefSeq NP_418674 NC_000913.3 # RefSeq WP_000036434 NZ_CP014272.1 # SEQUENCE CAUTION Sequence=AAA97149.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; BLAST swissprot:YJGL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJGL_ECOLI BioCyc ECOL316407:JW5757-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5757-MONOMER BioCyc EcoCyc:G7884-MONOMER http://biocyc.org/getid?id=EcoCyc:G7884-MONOMER DIP DIP-12607N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12607N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2421 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2421 EcoGene EG12531 http://www.ecogene.org/geneInfo.php?eg_id=EG12531 EnsemblBacteria AAC77210 http://www.ensemblgenomes.org/id/AAC77210 EnsemblBacteria AAC77210 http://www.ensemblgenomes.org/id/AAC77210 EnsemblBacteria BAE78250 http://www.ensemblgenomes.org/id/BAE78250 EnsemblBacteria BAE78250 http://www.ensemblgenomes.org/id/BAE78250 EnsemblBacteria BAE78250 http://www.ensemblgenomes.org/id/BAE78250 EnsemblBacteria b4253 http://www.ensemblgenomes.org/id/b4253 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 948776 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948776 HOGENOM HOG000054884 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000054884&db=HOGENOM6 IntAct P39336 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39336* KEGG_Gene ecj:JW5757 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5757 KEGG_Gene eco:b4253 http://www.genome.jp/dbget-bin/www_bget?eco:b4253 MINT MINT-1230236 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1230236 OMA GSEIMNF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GSEIMNF PSORT swissprot:YJGL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJGL_ECOLI PSORT-B swissprot:YJGL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJGL_ECOLI PSORT2 swissprot:YJGL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJGL_ECOLI Phobius swissprot:YJGL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJGL_ECOLI ProteinModelPortal P39336 http://www.proteinmodelportal.org/query/uniprot/P39336 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418674 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418674 RefSeq WP_000036434 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000036434 STRING 511145.b4253 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4253&targetmode=cogs UniProtKB YJGL_ECOLI http://www.uniprot.org/uniprot/YJGL_ECOLI UniProtKB-AC P39336 http://www.uniprot.org/uniprot/P39336 charge swissprot:YJGL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJGL_ECOLI epestfind swissprot:YJGL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJGL_ECOLI garnier swissprot:YJGL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJGL_ECOLI helixturnhelix swissprot:YJGL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJGL_ECOLI hmoment swissprot:YJGL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJGL_ECOLI iep swissprot:YJGL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJGL_ECOLI inforesidue swissprot:YJGL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJGL_ECOLI octanol swissprot:YJGL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJGL_ECOLI pepcoil swissprot:YJGL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJGL_ECOLI pepdigest swissprot:YJGL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJGL_ECOLI pepinfo swissprot:YJGL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJGL_ECOLI pepnet swissprot:YJGL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJGL_ECOLI pepstats swissprot:YJGL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJGL_ECOLI pepwheel swissprot:YJGL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJGL_ECOLI pepwindow swissprot:YJGL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJGL_ECOLI sigcleave swissprot:YJGL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJGL_ECOLI ## Database ID URL or Descriptions # BioGrid 4262117 282 # EcoGene EG14372 ecnA # FUNCTION ECNA_ECOLI Acts as antidote to the effect of entericidin B. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016020 membrane; IDA:EcoCyc. # GO_process GO:0009636 response to toxic substance; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0008150 biological_process # InterPro IPR012556 Entericidin # KEGG_Brite ko02000 Transporters # Organism ECNA_ECOLI Escherichia coli (strain K12) # PATRIC 32123865 VBIEscCol129921_4280 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF08085 Entericidin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ECNA_ECOLI Entericidin A # RefSeq WP_000977757 NZ_LN832404.1 # RefSeq YP_026283 NC_000913.3 # SIMILARITY Belongs to the EcnA/EcnB lipoprotein family. {ECO 0000305}. # SUBCELLULAR LOCATION ECNA_ECOLI Cell membrane; Lipid-anchor. # eggNOG COG5510 LUCA # eggNOG ENOG4107PEH Bacteria BLAST swissprot:ECNA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ECNA_ECOLI BioCyc ECOL316407:JW5737-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5737-MONOMER BioCyc EcoCyc:MONOMER0-1562 http://biocyc.org/getid?id=EcoCyc:MONOMER0-1562 DOI 10.1006/jmbi.1998.1894 http://dx.doi.org/10.1006/jmbi.1998.1894 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL U21726 http://www.ebi.ac.uk/ena/data/view/U21726 EchoBASE EB4115 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4115 EcoGene EG14372 http://www.ecogene.org/geneInfo.php?eg_id=EG14372 EnsemblBacteria AAT48241 http://www.ensemblgenomes.org/id/AAT48241 EnsemblBacteria AAT48241 http://www.ensemblgenomes.org/id/AAT48241 EnsemblBacteria BAE78150 http://www.ensemblgenomes.org/id/BAE78150 EnsemblBacteria BAE78150 http://www.ensemblgenomes.org/id/BAE78150 EnsemblBacteria BAE78150 http://www.ensemblgenomes.org/id/BAE78150 EnsemblBacteria b4410 http://www.ensemblgenomes.org/id/b4410 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_process GO:0009636 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009636 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 2847736 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2847736 HOGENOM HOG000211677 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000211677&db=HOGENOM6 InterPro IPR012556 http://www.ebi.ac.uk/interpro/entry/IPR012556 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5737 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5737 KEGG_Gene eco:b4410 http://www.genome.jp/dbget-bin/www_bget?eco:b4410 KEGG_Orthology KO:K16347 http://www.genome.jp/dbget-bin/www_bget?KO:K16347 PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:ECNA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ECNA_ECOLI PSORT-B swissprot:ECNA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ECNA_ECOLI PSORT2 swissprot:ECNA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ECNA_ECOLI Pfam PF08085 http://pfam.xfam.org/family/PF08085 Phobius swissprot:ECNA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ECNA_ECOLI ProteinModelPortal P0ADB4 http://www.proteinmodelportal.org/query/uniprot/P0ADB4 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9677290 http://www.ncbi.nlm.nih.gov/pubmed/9677290 RefSeq WP_000977757 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000977757 RefSeq YP_026283 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026283 STRING 511145.b4410 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4410&targetmode=cogs UniProtKB ECNA_ECOLI http://www.uniprot.org/uniprot/ECNA_ECOLI UniProtKB-AC P0ADB4 http://www.uniprot.org/uniprot/P0ADB4 charge swissprot:ECNA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ECNA_ECOLI eggNOG COG5510 http://eggnogapi.embl.de/nog_data/html/tree/COG5510 eggNOG ENOG4107PEH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107PEH epestfind swissprot:ECNA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ECNA_ECOLI garnier swissprot:ECNA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ECNA_ECOLI helixturnhelix swissprot:ECNA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ECNA_ECOLI hmoment swissprot:ECNA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ECNA_ECOLI iep swissprot:ECNA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ECNA_ECOLI inforesidue swissprot:ECNA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ECNA_ECOLI octanol swissprot:ECNA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ECNA_ECOLI pepcoil swissprot:ECNA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ECNA_ECOLI pepdigest swissprot:ECNA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ECNA_ECOLI pepinfo swissprot:ECNA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ECNA_ECOLI pepnet swissprot:ECNA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ECNA_ECOLI pepstats swissprot:ECNA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ECNA_ECOLI pepwheel swissprot:ECNA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ECNA_ECOLI pepwindow swissprot:ECNA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ECNA_ECOLI sigcleave swissprot:ECNA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ECNA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262127 215 # CDD cd06261 TM_PBP2 # EcoGene EG14005 ynjC # FUNCTION YNJC_ECOLI Probably part of the binding-protein-dependent transport system YnjCD. Probably responsible for the translocation of the substrate across the membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006810 transport; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006810 transport # Gene3D 1.10.3720.10 -; 2. # InterPro IPR000515 MetI-like # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00192 Putative thiamine transport system # KEGG_Brite ko02000 Transporters # Organism YNJC_ECOLI Escherichia coli (strain K12) # PATRIC 32118821 VBIEscCol129921_1828 # PIR C64935 C64935 # PROSITE PS50928 ABC_TM1; 2 # Pfam PF00528 BPD_transp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNJC_ECOLI Inner membrane ABC transporter permease protein YnjC # RefSeq NP_416269 NC_000913.3 # RefSeq WP_000224958 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA15546.2; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. {ECO 0000305}. # SIMILARITY Contains 2 ABC transmembrane type-1 domains. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION YNJC_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF161098 SSF161098; 2 # eggNOG COG4135 LUCA # eggNOG ENOG4105CXZ Bacteria BLAST swissprot:YNJC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNJC_ECOLI BioCyc ECOL316407:JW5285-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5285-MONOMER BioCyc EcoCyc:YNJC-MONOMER http://biocyc.org/getid?id=EcoCyc:YNJC-MONOMER COG COG4135 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4135 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3761 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3761 EcoGene EG14005 http://www.ecogene.org/geneInfo.php?eg_id=EG14005 EnsemblBacteria AAC74825 http://www.ensemblgenomes.org/id/AAC74825 EnsemblBacteria AAC74825 http://www.ensemblgenomes.org/id/AAC74825 EnsemblBacteria BAA15546 http://www.ensemblgenomes.org/id/BAA15546 EnsemblBacteria BAA15546 http://www.ensemblgenomes.org/id/BAA15546 EnsemblBacteria BAA15546 http://www.ensemblgenomes.org/id/BAA15546 EnsemblBacteria b1755 http://www.ensemblgenomes.org/id/b1755 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 946273 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946273 HOGENOM HOG000275274 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275274&db=HOGENOM6 InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5285 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5285 KEGG_Gene eco:b1755 http://www.genome.jp/dbget-bin/www_bget?eco:b1755 KEGG_Orthology KO:K05778 http://www.genome.jp/dbget-bin/www_bget?KO:K05778 OMA ESAFVLW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ESAFVLW PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:YNJC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNJC_ECOLI PSORT-B swissprot:YNJC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNJC_ECOLI PSORT2 swissprot:YNJC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNJC_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Phobius swissprot:YNJC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNJC_ECOLI ProteinModelPortal P76224 http://www.proteinmodelportal.org/query/uniprot/P76224 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416269 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416269 RefSeq WP_000224958 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000224958 SMR P76224 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76224 STRING 511145.b1755 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1755&targetmode=cogs STRING COG4135 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4135&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 UniProtKB YNJC_ECOLI http://www.uniprot.org/uniprot/YNJC_ECOLI UniProtKB-AC P76224 http://www.uniprot.org/uniprot/P76224 charge swissprot:YNJC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNJC_ECOLI eggNOG COG4135 http://eggnogapi.embl.de/nog_data/html/tree/COG4135 eggNOG ENOG4105CXZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CXZ epestfind swissprot:YNJC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNJC_ECOLI garnier swissprot:YNJC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNJC_ECOLI helixturnhelix swissprot:YNJC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNJC_ECOLI hmoment swissprot:YNJC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNJC_ECOLI iep swissprot:YNJC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNJC_ECOLI inforesidue swissprot:YNJC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNJC_ECOLI octanol swissprot:YNJC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNJC_ECOLI pepcoil swissprot:YNJC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNJC_ECOLI pepdigest swissprot:YNJC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNJC_ECOLI pepinfo swissprot:YNJC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNJC_ECOLI pepnet swissprot:YNJC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNJC_ECOLI pepstats swissprot:YNJC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNJC_ECOLI pepwheel swissprot:YNJC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNJC_ECOLI pepwindow swissprot:YNJC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNJC_ECOLI sigcleave swissprot:YNJC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNJC_ECOLI ## Database ID URL or Descriptions # ALTERNATIVE PRODUCTS MCRB_ECOLI Event=Alternative initiation; Named isoforms=2; Name=51 kDa; IsoId=P15005-1; Sequence=Displayed; Name=33 kDa; IsoId=P15005-2; Sequence=VSP_018868; # AltName MCRB_ECOLI EcoKMcrBC # BioGrid 4262765 160 # EcoGene EG10574 mcrB # FUNCTION MCRB_ECOLI Recognizes N4- and C5-methylcytosine (and 5-hydroxy- methylcytosines) produced by a broad range of DNA methylases and appears to act against 5-methylcytosine preceded by a purine residue. Binds to DNA containing methylated cytosines; also binds to GTP. Isoform 33 kDa is less active than isoform 51 kDa and may play a role in regulating the activity of isoform 51 kDa by competing with it in DNA and protein binding abilities. # GO_function GO:0003677 DNA binding; IDA:EcoliWiki. # GO_function GO:0003924 GTPase activity; IDA:EcoliWiki. # GO_function GO:0005524 ATP binding; IEA:InterPro. # GO_function GO:0005525 GTP binding; IEA:UniProtKB-KW. # GO_function GO:0015666 restriction endodeoxyribonuclease activity; IDA:EcoliWiki. # GO_function GO:0016887 ATPase activity; IEA:InterPro. # GO_process GO:0006308 DNA catabolic process; IDA:EcoliWiki. # GO_process GO:0009307 DNA restriction-modification system; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0003924 GTPase activity # GOslim_function GO:0004518 nuclease activity # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # Gene3D 3.40.50.300 -; 1. # IntAct P15005 3 # InterPro IPR003593 AAA+_ATPase # InterPro IPR011704 ATPase_dyneun-rel_AAA # InterPro IPR021961 DUF3578 # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko01000 Enzymes # Organism MCRB_ECOLI Escherichia coli (strain K12) # PATRIC 32124298 VBIEscCol129921_4492 # PDB 3SSC X-ray; 2.10 A; A/B=1-161 # PDB 3SSD X-ray; 2.20 A; A/B=1-161 # PDB 3SSE X-ray; 2.70 A; A/B=1-161 # PIR A36708 XYECMB # Pfam PF07728 AAA_5 # Pfam PF12102 DUF3578 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # REBASE 2865 EcoKMcrBC # RecName MCRB_ECOLI 5-methylcytosine-specific restriction enzyme B # RefSeq NP_418766 NC_000913.3 # RefSeq WP_000443951 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA24145.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAA97243.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SMART SM00382 AAA # SUPFAM SSF52540 SSF52540 # eggNOG COG1401 LUCA # eggNOG ENOG4105FBQ Bacteria BLAST swissprot:MCRB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MCRB_ECOLI BioCyc ECOL316407:JW5871-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5871-MONOMER BioCyc EcoCyc:EG10574-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10574-MONOMER BioCyc MetaCyc:EG10574-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10574-MONOMER COG COG1401 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1401 DIP DIP-10168N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10168N DOI 10.1016/0378-1119(92)90308-C http://dx.doi.org/10.1016/0378-1119(92)90308-C DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.21.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.21.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M24927 http://www.ebi.ac.uk/ena/data/view/M24927 EMBL M58752 http://www.ebi.ac.uk/ena/data/view/M58752 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 3.1.21.- http://enzyme.expasy.org/EC/3.1.21.- EchoBASE EB0569 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0569 EcoGene EG10574 http://www.ecogene.org/geneInfo.php?eg_id=EG10574 EnsemblBacteria AAC77302 http://www.ensemblgenomes.org/id/AAC77302 EnsemblBacteria AAC77302 http://www.ensemblgenomes.org/id/AAC77302 EnsemblBacteria BAE78336 http://www.ensemblgenomes.org/id/BAE78336 EnsemblBacteria BAE78336 http://www.ensemblgenomes.org/id/BAE78336 EnsemblBacteria BAE78336 http://www.ensemblgenomes.org/id/BAE78336 EnsemblBacteria b4346 http://www.ensemblgenomes.org/id/b4346 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_function GO:0015666 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015666 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_process GO:0006308 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006308 GO_process GO:0009307 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009307 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 949122 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949122 HOGENOM HOG000081315 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000081315&db=HOGENOM6 InParanoid P15005 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P15005 IntAct P15005 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P15005* IntEnz 3.1.21 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.21 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR011704 http://www.ebi.ac.uk/interpro/entry/IPR011704 InterPro IPR021961 http://www.ebi.ac.uk/interpro/entry/IPR021961 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5871 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5871 KEGG_Gene eco:b4346 http://www.genome.jp/dbget-bin/www_bget?eco:b4346 KEGG_Orthology KO:K07452 http://www.genome.jp/dbget-bin/www_bget?KO:K07452 MINT MINT-1286238 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1286238 OMA KAYLMES http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KAYLMES PDB 3SSC http://www.ebi.ac.uk/pdbe-srv/view/entry/3SSC PDB 3SSD http://www.ebi.ac.uk/pdbe-srv/view/entry/3SSD PDB 3SSE http://www.ebi.ac.uk/pdbe-srv/view/entry/3SSE PDBsum 3SSC http://www.ebi.ac.uk/pdbsum/3SSC PDBsum 3SSD http://www.ebi.ac.uk/pdbsum/3SSD PDBsum 3SSE http://www.ebi.ac.uk/pdbsum/3SSE PSORT swissprot:MCRB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MCRB_ECOLI PSORT-B swissprot:MCRB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MCRB_ECOLI PSORT2 swissprot:MCRB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MCRB_ECOLI Pfam PF07728 http://pfam.xfam.org/family/PF07728 Pfam PF12102 http://pfam.xfam.org/family/PF12102 Phobius swissprot:MCRB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MCRB_ECOLI PhylomeDB P15005 http://phylomedb.org/?seqid=P15005 ProteinModelPortal P15005 http://www.proteinmodelportal.org/query/uniprot/P15005 PubMed 1312983 http://www.ncbi.nlm.nih.gov/pubmed/1312983 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2203735 http://www.ncbi.nlm.nih.gov/pubmed/2203735 PubMed 2649480 http://www.ncbi.nlm.nih.gov/pubmed/2649480 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 7781618 http://www.ncbi.nlm.nih.gov/pubmed/7781618 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 REBASE 2865 http://rebase.neb.com/rebase/enz/2865.html RefSeq NP_418766 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418766 RefSeq WP_000443951 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000443951 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P15005 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P15005 STRING 511145.b4346 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4346&targetmode=cogs STRING COG1401 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1401&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB MCRB_ECOLI http://www.uniprot.org/uniprot/MCRB_ECOLI UniProtKB-AC P15005 http://www.uniprot.org/uniprot/P15005 charge swissprot:MCRB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MCRB_ECOLI eggNOG COG1401 http://eggnogapi.embl.de/nog_data/html/tree/COG1401 eggNOG ENOG4105FBQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FBQ epestfind swissprot:MCRB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MCRB_ECOLI garnier swissprot:MCRB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MCRB_ECOLI helixturnhelix swissprot:MCRB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MCRB_ECOLI hmoment swissprot:MCRB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MCRB_ECOLI iep swissprot:MCRB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MCRB_ECOLI inforesidue swissprot:MCRB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MCRB_ECOLI octanol swissprot:MCRB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MCRB_ECOLI pepcoil swissprot:MCRB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MCRB_ECOLI pepdigest swissprot:MCRB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MCRB_ECOLI pepinfo swissprot:MCRB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MCRB_ECOLI pepnet swissprot:MCRB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MCRB_ECOLI pepstats swissprot:MCRB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MCRB_ECOLI pepwheel swissprot:MCRB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MCRB_ECOLI pepwindow swissprot:MCRB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MCRB_ECOLI sigcleave swissprot:MCRB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MCRB_ECOLI ## Database ID URL or Descriptions # BioGrid 4261844 6 # DISRUPTION PHENOTYPE Cells show increased biofilm formation when glucose is present in the medium. In a continuous-flow system with M9C medium supplemented with glucose, the biofilm had a 290-fold greater biomass, a 2700-fold greater thickness and a 31-fold increased surface coverage than the wild-type. {ECO:0000269|PubMed 16597943}. # EcoGene EG13479 bssR # FUNCTION BSSR_ECOLI Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway. {ECO 0000269|PubMed 16597943}. # GO_process GO:0010468 regulation of gene expression; IEP:EcoCyc. # GO_process GO:1900190 regulation of single-species biofilm formation; IMP:EcoCyc. # GOslim_process GO:0008150 biological_process # InterPro IPR020359 Biofilm_regulator_BssR # Organism BSSR_ECOLI Escherichia coli (strain K12) # PATRIC 32116875 VBIEscCol129921_0863 # PIR D64821 D64821 # Pfam PF10799 YliH # ProDom PD079626 Biofilm_regulator_BssR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BSSR_ECOLI Biofilm regulator BssR # RefSeq NP_415357 NC_000913.3 # RefSeq WP_000497137 NZ_LN832404.1 # eggNOG ENOG4105UFT Bacteria # eggNOG ENOG4111WGP LUCA BLAST swissprot:BSSR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BSSR_ECOLI BioCyc ECOL316407:JW0820-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0820-MONOMER BioCyc EcoCyc:G6436-MONOMER http://biocyc.org/getid?id=EcoCyc:G6436-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AEM.72.4.2449-2459.2006 http://dx.doi.org/10.1128/AEM.72.4.2449-2459.2006 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3252 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3252 EcoGene EG13479 http://www.ecogene.org/geneInfo.php?eg_id=EG13479 EnsemblBacteria AAC73923 http://www.ensemblgenomes.org/id/AAC73923 EnsemblBacteria AAC73923 http://www.ensemblgenomes.org/id/AAC73923 EnsemblBacteria BAA35531 http://www.ensemblgenomes.org/id/BAA35531 EnsemblBacteria BAA35531 http://www.ensemblgenomes.org/id/BAA35531 EnsemblBacteria BAA35531 http://www.ensemblgenomes.org/id/BAA35531 EnsemblBacteria b0836 http://www.ensemblgenomes.org/id/b0836 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0010468 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010468 GO_process GO:1900190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1900190 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 945466 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945466 HOGENOM HOG000118194 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118194&db=HOGENOM6 InterPro IPR020359 http://www.ebi.ac.uk/interpro/entry/IPR020359 KEGG_Gene ecj:JW0820 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0820 KEGG_Gene eco:b0836 http://www.genome.jp/dbget-bin/www_bget?eco:b0836 OMA YMSVSEN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YMSVSEN PSORT swissprot:BSSR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BSSR_ECOLI PSORT-B swissprot:BSSR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BSSR_ECOLI PSORT2 swissprot:BSSR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BSSR_ECOLI Pfam PF10799 http://pfam.xfam.org/family/PF10799 Phobius swissprot:BSSR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BSSR_ECOLI ProteinModelPortal P0AAY1 http://www.proteinmodelportal.org/query/uniprot/P0AAY1 PubMed 16597943 http://www.ncbi.nlm.nih.gov/pubmed/16597943 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415357 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415357 RefSeq WP_000497137 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000497137 STRING 511145.b0836 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0836&targetmode=cogs UniProtKB BSSR_ECOLI http://www.uniprot.org/uniprot/BSSR_ECOLI UniProtKB-AC P0AAY1 http://www.uniprot.org/uniprot/P0AAY1 charge swissprot:BSSR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BSSR_ECOLI eggNOG ENOG4105UFT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105UFT eggNOG ENOG4111WGP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111WGP epestfind swissprot:BSSR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BSSR_ECOLI garnier swissprot:BSSR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BSSR_ECOLI helixturnhelix swissprot:BSSR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BSSR_ECOLI hmoment swissprot:BSSR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BSSR_ECOLI iep swissprot:BSSR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BSSR_ECOLI inforesidue swissprot:BSSR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BSSR_ECOLI octanol swissprot:BSSR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BSSR_ECOLI pepcoil swissprot:BSSR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BSSR_ECOLI pepdigest swissprot:BSSR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BSSR_ECOLI pepinfo swissprot:BSSR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BSSR_ECOLI pepnet swissprot:BSSR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BSSR_ECOLI pepstats swissprot:BSSR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BSSR_ECOLI pepwheel swissprot:BSSR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BSSR_ECOLI pepwindow swissprot:BSSR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BSSR_ECOLI sigcleave swissprot:BSSR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BSSR_ECOLI ## Database ID URL or Descriptions # BioGrid 4259238 239 # EcoGene EG11160 mscS # FUNCTION MSCS_ECOLI Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage; as the membrane is depolarized, less tension is required to open the channel and vice versa. The channel is characterized by short bursts of activity that last for a few seconds. # FUNCTION MSCS_ECOLI The channel pore is formed by TM3 and the loop between TM2 and TM3. After a sharp turn at Gly-113, an alpha-helix (residues 114-127) is oriented nearly parallel to the plane of the putative lipid bilayer. On the intracellular side of the channel, the permeation pathway of MscS does not connect directly to the cytoplasm but instead opens to a large chamber that is connected to the cytoplasm. This chamber resembles a molecular filter that could serve to prescreen large molecules before they are allowed passage to the transmembrane pore. The TM1 and TM2 helices appear to be likely candidates for mediating the tension and voltage sensitivities of MscS. Gating requires large rearrangements of at least the C-terminus. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IDA:EcoCyc. # GO_function GO:0008381 mechanically-gated ion channel activity; IDA:EcoCyc. # GO_process GO:0009992 cellular water homeostasis; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0042592 homeostatic process # IntAct P0C0S1 2 # InterPro IPR006685 MscS_channel # InterPro IPR006686 MscS_channel_CS # InterPro IPR008910 TM_helix # InterPro IPR010920 LSM_dom # InterPro IPR011014 MscS_channel_TM-2 # InterPro IPR011066 MscC_channel_C # KEGG_Brite ko02000 Transporters # Organism MSCS_ECOLI Escherichia coli (strain K12) # PATRIC 32121262 VBIEscCol129921_3019 # PDB 2OAU X-ray; 3.70 A; A/B/C/D/E/F/G=1-286 # PDB 2VV5 X-ray; 3.45 A; A/B/C/D/E/F/G=1-286 # PDB 3UDC X-ray; 3.36 A; A/B/C/D/E/F/G=272-286 # PDB 4AGE X-ray; 4.84 A; A/B/C/D/E/F/G=1-286 # PDB 4AGF X-ray; 4.70 A; A/B/C/D/E/F/G=1-286 # PDB 4HWA X-ray; 4.37 A; A/B/C/D/E/F/G=1-286 # PDB 5AJI X-ray; 2.99 A; A/B/C/D/E/F/G=1-286 # PIR S04735 QQEC4A # PROSITE PS01246 UPF0003 # Pfam PF00924 MS_channel # Pfam PF05552 TM_helix # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MSCS_ECOLI Small-conductance mechanosensitive channel # RefSeq NP_417399 NC_000913.3 # RefSeq WP_000389818 NZ_LN832404.1 # SIMILARITY Belongs to the MscS (TC 1.A.23) family. {ECO 0000305}. # SUBCELLULAR LOCATION MSCS_ECOLI Cell inner membrane {ECO 0000269|PubMed 16079137}; Multi-pass membrane protein {ECO 0000269|PubMed 16079137}. # SUBUNIT MSCS_ECOLI Homoheptamer. {ECO 0000269|PubMed 12446901, ECO 0000269|PubMed 12767977, ECO 0000269|PubMed 16079137}. # SUPFAM SSF50182 SSF50182 # SUPFAM SSF82689 SSF82689 # SUPFAM SSF82861 SSF82861 # TCDB 1.A.23.2 the small conductance mechanosensitive ion channel (mscs) family # eggNOG COG0668 LUCA # eggNOG ENOG4105D64 Bacteria BLAST swissprot:MSCS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MSCS_ECOLI BioCyc ECOL316407:JW2891-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2891-MONOMER BioCyc EcoCyc:EG11160-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11160-MONOMER COG COG0668 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0668 DIP DIP-36192N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36192N DOI 10.1007/BF00238414 http://dx.doi.org/10.1007/BF00238414 DOI 10.1016/S0006-3495(02)75169-2 http://dx.doi.org/10.1016/S0006-3495(02)75169-2 DOI 10.1016/j.febslet.2004.07.045 http://dx.doi.org/10.1016/j.febslet.2004.07.045 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsmb895 http://dx.doi.org/10.1038/nsmb895 DOI 10.1073/pnas.84.8.2297 http://dx.doi.org/10.1073/pnas.84.8.2297 DOI 10.1074/jbc.M202497200 http://dx.doi.org/10.1074/jbc.M202497200 DOI 10.1074/jbc.M212073200 http://dx.doi.org/10.1074/jbc.M212073200 DOI 10.1074/jbc.M303188200 http://dx.doi.org/10.1074/jbc.M303188200 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1093/emboj/18.7.1730 http://dx.doi.org/10.1093/emboj/18.7.1730 DOI 10.1111/j.1365-2958.1989.tb00221.x http://dx.doi.org/10.1111/j.1365-2958.1989.tb00221.x DOI 10.1126/science.1077945 http://dx.doi.org/10.1126/science.1077945 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EMBL X14436 http://www.ebi.ac.uk/ena/data/view/X14436 EchoBASE EB1149 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1149 EcoGene EG11160 http://www.ecogene.org/geneInfo.php?eg_id=EG11160 EnsemblBacteria AAC75961 http://www.ensemblgenomes.org/id/AAC75961 EnsemblBacteria AAC75961 http://www.ensemblgenomes.org/id/AAC75961 EnsemblBacteria BAE76988 http://www.ensemblgenomes.org/id/BAE76988 EnsemblBacteria BAE76988 http://www.ensemblgenomes.org/id/BAE76988 EnsemblBacteria BAE76988 http://www.ensemblgenomes.org/id/BAE76988 EnsemblBacteria b2924 http://www.ensemblgenomes.org/id/b2924 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008381 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008381 GO_process GO:0009992 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009992 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GeneID 947416 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947416 HOGENOM HOG000110050 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000110050&db=HOGENOM6 InParanoid P0C0S1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0C0S1 IntAct P0C0S1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0C0S1* InterPro IPR006685 http://www.ebi.ac.uk/interpro/entry/IPR006685 InterPro IPR006686 http://www.ebi.ac.uk/interpro/entry/IPR006686 InterPro IPR008910 http://www.ebi.ac.uk/interpro/entry/IPR008910 InterPro IPR010920 http://www.ebi.ac.uk/interpro/entry/IPR010920 InterPro IPR011014 http://www.ebi.ac.uk/interpro/entry/IPR011014 InterPro IPR011066 http://www.ebi.ac.uk/interpro/entry/IPR011066 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2891 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2891 KEGG_Gene eco:b2924 http://www.genome.jp/dbget-bin/www_bget?eco:b2924 KEGG_Orthology KO:K03442 http://www.genome.jp/dbget-bin/www_bget?KO:K03442 OMA WPVYWDL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WPVYWDL PDB 2OAU http://www.ebi.ac.uk/pdbe-srv/view/entry/2OAU PDB 2VV5 http://www.ebi.ac.uk/pdbe-srv/view/entry/2VV5 PDB 3UDC http://www.ebi.ac.uk/pdbe-srv/view/entry/3UDC PDB 4AGE http://www.ebi.ac.uk/pdbe-srv/view/entry/4AGE PDB 4AGF http://www.ebi.ac.uk/pdbe-srv/view/entry/4AGF PDB 4HWA http://www.ebi.ac.uk/pdbe-srv/view/entry/4HWA PDB 5AJI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AJI PDBsum 2OAU http://www.ebi.ac.uk/pdbsum/2OAU PDBsum 2VV5 http://www.ebi.ac.uk/pdbsum/2VV5 PDBsum 3UDC http://www.ebi.ac.uk/pdbsum/3UDC PDBsum 4AGE http://www.ebi.ac.uk/pdbsum/4AGE PDBsum 4AGF http://www.ebi.ac.uk/pdbsum/4AGF PDBsum 4HWA http://www.ebi.ac.uk/pdbsum/4HWA PDBsum 5AJI http://www.ebi.ac.uk/pdbsum/5AJI PROSITE PS01246 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01246 PSORT swissprot:MSCS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MSCS_ECOLI PSORT-B swissprot:MSCS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MSCS_ECOLI PSORT2 swissprot:MSCS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MSCS_ECOLI Pfam PF00924 http://pfam.xfam.org/family/PF00924 Pfam PF05552 http://pfam.xfam.org/family/PF05552 Phobius swissprot:MSCS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MSCS_ECOLI PhylomeDB P0C0S1 http://phylomedb.org/?seqid=P0C0S1 ProteinModelPortal P0C0S1 http://www.proteinmodelportal.org/query/uniprot/P0C0S1 PubMed 10202137 http://www.ncbi.nlm.nih.gov/pubmed/10202137 PubMed 12015316 http://www.ncbi.nlm.nih.gov/pubmed/12015316 PubMed 12080120 http://www.ncbi.nlm.nih.gov/pubmed/12080120 PubMed 12446901 http://www.ncbi.nlm.nih.gov/pubmed/12446901 PubMed 12551944 http://www.ncbi.nlm.nih.gov/pubmed/12551944 PubMed 12767977 http://www.ncbi.nlm.nih.gov/pubmed/12767977 PubMed 15304354 http://www.ncbi.nlm.nih.gov/pubmed/15304354 PubMed 15665866 http://www.ncbi.nlm.nih.gov/pubmed/15665866 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2436228 http://www.ncbi.nlm.nih.gov/pubmed/2436228 PubMed 2546007 http://www.ncbi.nlm.nih.gov/pubmed/2546007 PubMed 7595939 http://www.ncbi.nlm.nih.gov/pubmed/7595939 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417399 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417399 RefSeq WP_000389818 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000389818 SMR P0C0S1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0C0S1 STRING 511145.b2924 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2924&targetmode=cogs STRING COG0668 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0668&targetmode=cogs SUPFAM SSF50182 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50182 SUPFAM SSF82689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF82689 SUPFAM SSF82861 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF82861 TCDB 1.A.23.2 http://www.tcdb.org/search/result.php?tc=1.A.23.2 UniProtKB MSCS_ECOLI http://www.uniprot.org/uniprot/MSCS_ECOLI UniProtKB-AC P0C0S1 http://www.uniprot.org/uniprot/P0C0S1 charge swissprot:MSCS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MSCS_ECOLI eggNOG COG0668 http://eggnogapi.embl.de/nog_data/html/tree/COG0668 eggNOG ENOG4105D64 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D64 epestfind swissprot:MSCS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MSCS_ECOLI garnier swissprot:MSCS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MSCS_ECOLI helixturnhelix swissprot:MSCS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MSCS_ECOLI hmoment swissprot:MSCS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MSCS_ECOLI iep swissprot:MSCS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MSCS_ECOLI inforesidue swissprot:MSCS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MSCS_ECOLI octanol swissprot:MSCS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MSCS_ECOLI pepcoil swissprot:MSCS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MSCS_ECOLI pepdigest swissprot:MSCS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MSCS_ECOLI pepinfo swissprot:MSCS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MSCS_ECOLI pepnet swissprot:MSCS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MSCS_ECOLI pepstats swissprot:MSCS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MSCS_ECOLI pepwheel swissprot:MSCS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MSCS_ECOLI pepwindow swissprot:MSCS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MSCS_ECOLI sigcleave swissprot:MSCS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MSCS_ECOLI ## Database ID URL or Descriptions # BioGrid 4260929 9 # COFACTOR AEGA_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000250}; Note=Binds 4 [4Fe-4S] clusters. {ECO 0000250}; # EcoGene EG12409 aegA # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0016491 oxidoreductase activity; IBA:GO_Central. # GO_function GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor; IEA:InterPro. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0006537 glutamate biosynthetic process; IEA:InterPro. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.720 -; 2. # IntAct P37127 6 # InterPro IPR006006 Glut_synth_ssu2 # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR017896 4Fe4S_Fe-S-bd # InterPro IPR017900 4Fe4S_Fe_S_CS # InterPro IPR023753 FAD/NAD-binding_dom # InterPro IPR028261 DPD_II # Organism AEGA_ECOLI Escherichia coli (strain K12) # PATRIC 32120319 VBIEscCol129921_2562 # PIR C65022 C65022 # PROSITE PS00198 4FE4S_FER_1 # PROSITE PS51379 4FE4S_FER_2; 5 # Pfam PF07992 Pyr_redox_2 # Pfam PF13247 Fer4_11 # Pfam PF14691 Fer4_20 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AEGA_ECOLI Protein AegA # RefSeq NP_416963 NC_000913.3 # RefSeq WP_001078880 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB46944.1; Type=Frameshift; Positions=602; Evidence={ECO 0000305}; # SIMILARITY Contains 4 4Fe-4S ferredoxin-type domains. {ECO:0000255|PROSITE-ProRule PRU00711}. # TIGRFAMs TIGR01318 gltD_gamma_fam # eggNOG COG0493 LUCA # eggNOG COG1142 LUCA # eggNOG ENOG4105BZ8 Bacteria BLAST swissprot:AEGA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AEGA_ECOLI BioCyc ECOL316407:JW2452-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2452-MONOMER BioCyc EcoCyc:EG12409-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12409-MONOMER DIP DIP-9060N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9060N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L34011 http://www.ebi.ac.uk/ena/data/view/L34011 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2308 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2308 EcoGene EG12409 http://www.ecogene.org/geneInfo.php?eg_id=EG12409 EnsemblBacteria AAC75521 http://www.ensemblgenomes.org/id/AAC75521 EnsemblBacteria AAC75521 http://www.ensemblgenomes.org/id/AAC75521 EnsemblBacteria BAA16342 http://www.ensemblgenomes.org/id/BAA16342 EnsemblBacteria BAA16342 http://www.ensemblgenomes.org/id/BAA16342 EnsemblBacteria BAA16342 http://www.ensemblgenomes.org/id/BAA16342 EnsemblBacteria b2468 http://www.ensemblgenomes.org/id/b2468 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0016639 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016639 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0006537 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006537 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 947383 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947383 HOGENOM HOG000031439 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000031439&db=HOGENOM6 InParanoid P37127 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37127 IntAct P37127 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37127* InterPro IPR006006 http://www.ebi.ac.uk/interpro/entry/IPR006006 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR017896 http://www.ebi.ac.uk/interpro/entry/IPR017896 InterPro IPR017900 http://www.ebi.ac.uk/interpro/entry/IPR017900 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 InterPro IPR028261 http://www.ebi.ac.uk/interpro/entry/IPR028261 KEGG_Gene ecj:JW2452 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2452 KEGG_Gene eco:b2468 http://www.genome.jp/dbget-bin/www_bget?eco:b2468 OMA VESRYRY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VESRYRY PROSITE PS00198 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00198 PROSITE PS51379 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51379 PSORT swissprot:AEGA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AEGA_ECOLI PSORT-B swissprot:AEGA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AEGA_ECOLI PSORT2 swissprot:AEGA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AEGA_ECOLI Pfam PF07992 http://pfam.xfam.org/family/PF07992 Pfam PF13247 http://pfam.xfam.org/family/PF13247 Pfam PF14691 http://pfam.xfam.org/family/PF14691 Phobius swissprot:AEGA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AEGA_ECOLI PhylomeDB P37127 http://phylomedb.org/?seqid=P37127 ProteinModelPortal P37127 http://www.proteinmodelportal.org/query/uniprot/P37127 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8955321 http://www.ncbi.nlm.nih.gov/pubmed/8955321 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416963 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416963 RefSeq WP_001078880 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001078880 SMR P37127 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37127 STRING 511145.b2468 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2468&targetmode=cogs TIGRFAMs TIGR01318 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01318 UniProtKB AEGA_ECOLI http://www.uniprot.org/uniprot/AEGA_ECOLI UniProtKB-AC P37127 http://www.uniprot.org/uniprot/P37127 charge swissprot:AEGA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AEGA_ECOLI eggNOG COG0493 http://eggnogapi.embl.de/nog_data/html/tree/COG0493 eggNOG COG1142 http://eggnogapi.embl.de/nog_data/html/tree/COG1142 eggNOG ENOG4105BZ8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZ8 epestfind swissprot:AEGA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AEGA_ECOLI garnier swissprot:AEGA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AEGA_ECOLI helixturnhelix swissprot:AEGA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AEGA_ECOLI hmoment swissprot:AEGA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AEGA_ECOLI iep swissprot:AEGA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AEGA_ECOLI inforesidue swissprot:AEGA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AEGA_ECOLI octanol swissprot:AEGA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AEGA_ECOLI pepcoil swissprot:AEGA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AEGA_ECOLI pepdigest swissprot:AEGA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AEGA_ECOLI pepinfo swissprot:AEGA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AEGA_ECOLI pepnet swissprot:AEGA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AEGA_ECOLI pepstats swissprot:AEGA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AEGA_ECOLI pepwheel swissprot:AEGA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AEGA_ECOLI pepwindow swissprot:AEGA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AEGA_ECOLI sigcleave swissprot:AEGA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AEGA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261425 11 # EcoGene EG10486 hypD # FUNCTION HYPD_ECOLI Required for the formation of all three hydrogenase isoenzymes. # GO_function GO:0005506 iron ion binding; IDA:EcoCyc. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IDA:EcoCyc. # GO_function GO:0070025 carbon monoxide binding; IDA:EcoCyc. # GO_process GO:0006464 cellular protein modification process; IMP:EcoCyc. # GO_process GO:0051604 protein maturation; IMP:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0051604 protein maturation # INTERACTION HYPD_ECOLI P0AAM7 hybG; NbExp=7; IntAct=EBI-552711, EBI-562426; # IntAct P24192 8 # InterPro IPR002780 Hyd_form_HypD # Organism HYPD_ECOLI Escherichia coli (strain K12) # PATRIC 32120858 VBIEscCol129921_2821 # PIR S15200 S15200 # PIRSF PIRSF005622 Hydrgn_mat_hypD # Pfam PF01924 HypD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HYPD_ECOLI Hydrogenase isoenzymes formation protein HypD # RefSeq NP_417209 NC_000913.3 # RefSeq WP_001212985 NZ_LN832404.1 # SIMILARITY Belongs to the HypD family. {ECO 0000305}. # TIGRFAMs TIGR00075 hypD # eggNOG COG0409 LUCA # eggNOG ENOG4105CQS Bacteria BLAST swissprot:HYPD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HYPD_ECOLI BioCyc ECOL316407:JW2699-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2699-MONOMER BioCyc EcoCyc:EG10486-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10486-MONOMER COG COG0409 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0409 DIP DIP-9998N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9998N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1991.tb01833.x http://dx.doi.org/10.1111/j.1365-2958.1991.tb01833.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EMBL X54543 http://www.ebi.ac.uk/ena/data/view/X54543 EchoBASE EB0481 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0481 EcoGene EG10486 http://www.ecogene.org/geneInfo.php?eg_id=EG10486 EnsemblBacteria AAC75771 http://www.ensemblgenomes.org/id/AAC75771 EnsemblBacteria AAC75771 http://www.ensemblgenomes.org/id/AAC75771 EnsemblBacteria BAE76806 http://www.ensemblgenomes.org/id/BAE76806 EnsemblBacteria BAE76806 http://www.ensemblgenomes.org/id/BAE76806 EnsemblBacteria BAE76806 http://www.ensemblgenomes.org/id/BAE76806 EnsemblBacteria b2729 http://www.ensemblgenomes.org/id/b2729 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_function GO:0070025 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070025 GO_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GO_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 GeneID 947189 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947189 HOGENOM HOG000278766 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278766&db=HOGENOM6 InParanoid P24192 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P24192 IntAct P24192 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P24192* InterPro IPR002780 http://www.ebi.ac.uk/interpro/entry/IPR002780 KEGG_Gene ecj:JW2699 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2699 KEGG_Gene eco:b2729 http://www.genome.jp/dbget-bin/www_bget?eco:b2729 KEGG_Orthology KO:K04654 http://www.genome.jp/dbget-bin/www_bget?KO:K04654 MINT MINT-1239502 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1239502 OMA LFFHINH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LFFHINH PSORT swissprot:HYPD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HYPD_ECOLI PSORT-B swissprot:HYPD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HYPD_ECOLI PSORT2 swissprot:HYPD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HYPD_ECOLI Pfam PF01924 http://pfam.xfam.org/family/PF01924 Phobius swissprot:HYPD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HYPD_ECOLI PhylomeDB P24192 http://phylomedb.org/?seqid=P24192 ProteinModelPortal P24192 http://www.proteinmodelportal.org/query/uniprot/P24192 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1849603 http://www.ncbi.nlm.nih.gov/pubmed/1849603 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417209 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417209 RefSeq WP_001212985 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001212985 SMR P24192 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P24192 STRING 511145.b2729 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2729&targetmode=cogs STRING COG0409 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0409&targetmode=cogs SWISS-2DPAGE P24192 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P24192 TIGRFAMs TIGR00075 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00075 UniProtKB HYPD_ECOLI http://www.uniprot.org/uniprot/HYPD_ECOLI UniProtKB-AC P24192 http://www.uniprot.org/uniprot/P24192 charge swissprot:HYPD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HYPD_ECOLI eggNOG COG0409 http://eggnogapi.embl.de/nog_data/html/tree/COG0409 eggNOG ENOG4105CQS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CQS epestfind swissprot:HYPD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HYPD_ECOLI garnier swissprot:HYPD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HYPD_ECOLI helixturnhelix swissprot:HYPD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HYPD_ECOLI hmoment swissprot:HYPD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HYPD_ECOLI iep swissprot:HYPD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HYPD_ECOLI inforesidue swissprot:HYPD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HYPD_ECOLI octanol swissprot:HYPD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HYPD_ECOLI pepcoil swissprot:HYPD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HYPD_ECOLI pepdigest swissprot:HYPD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HYPD_ECOLI pepinfo swissprot:HYPD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HYPD_ECOLI pepnet swissprot:HYPD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HYPD_ECOLI pepstats swissprot:HYPD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HYPD_ECOLI pepwheel swissprot:HYPD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HYPD_ECOLI pepwindow swissprot:HYPD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HYPD_ECOLI sigcleave swissprot:HYPD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HYPD_ECOLI ## Database ID URL or Descriptions # BioGrid 4260599 11 # CAUTION Was originally suggested to positively regulate sigma-E activity in vitro. {ECO:0000305|PubMed 9159522}. # DISRUPTION PHENOTYPE RSEC_ECOLI No effect on sigma-E (rpoE) activity. {ECO 0000269|PubMed 9159522, ECO 0000269|PubMed 9159523}. # EcoGene EG13178 rseC # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006979 response to oxidative stress; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006950 response to stress # InterPro IPR007359 SigmaE_reg_RseC_MucC # InterPro IPR026268 RseC # MISCELLANEOUS RSEC_ECOLI Part of the rpoE-rseA-rseB-rseC operon. # Organism RSEC_ECOLI Escherichia coli (strain K12) # PATRIC 32120539 VBIEscCol129921_2672 # PIR I83299 I83299 # PIRSF PIRSF004923 RseC # Pfam PF04246 RseC_MucC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RSEC_ECOLI Protein RseC # RefSeq NP_417065 NC_000913.3 # RefSeq WP_000589068 NZ_LN832404.1 # SIMILARITY Belongs to the RseC family. {ECO 0000305}. # SUBCELLULAR LOCATION RSEC_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG COG3086 LUCA # eggNOG ENOG4105WMJ Bacteria BLAST swissprot:RSEC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RSEC_ECOLI BioCyc ECOL316407:JW2554-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2554-MONOMER BioCyc EcoCyc:G7347-MONOMER http://biocyc.org/getid?id=EcoCyc:G7347-MONOMER COG COG3086 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3086 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1997.3601713.x http://dx.doi.org/10.1046/j.1365-2958.1997.3601713.x DOI 10.1046/j.1365-2958.1997.3611718.x http://dx.doi.org/10.1046/j.1365-2958.1997.3611718.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D64044 http://www.ebi.ac.uk/ena/data/view/D64044 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U37089 http://www.ebi.ac.uk/ena/data/view/U37089 EMBL U37455 http://www.ebi.ac.uk/ena/data/view/U37455 EchoBASE EB2970 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2970 EcoGene EG13178 http://www.ecogene.org/geneInfo.php?eg_id=EG13178 EnsemblBacteria AAC75623 http://www.ensemblgenomes.org/id/AAC75623 EnsemblBacteria AAC75623 http://www.ensemblgenomes.org/id/AAC75623 EnsemblBacteria BAE76746 http://www.ensemblgenomes.org/id/BAE76746 EnsemblBacteria BAE76746 http://www.ensemblgenomes.org/id/BAE76746 EnsemblBacteria BAE76746 http://www.ensemblgenomes.org/id/BAE76746 EnsemblBacteria b2570 http://www.ensemblgenomes.org/id/b2570 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 947052 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947052 HOGENOM HOG000272284 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000272284&db=HOGENOM6 InParanoid P46187 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P46187 InterPro IPR007359 http://www.ebi.ac.uk/interpro/entry/IPR007359 InterPro IPR026268 http://www.ebi.ac.uk/interpro/entry/IPR026268 KEGG_Gene ecj:JW2554 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2554 KEGG_Gene eco:b2570 http://www.genome.jp/dbget-bin/www_bget?eco:b2570 KEGG_Orthology KO:K03803 http://www.genome.jp/dbget-bin/www_bget?KO:K03803 OMA GCGSCQA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GCGSCQA PSORT swissprot:RSEC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RSEC_ECOLI PSORT-B swissprot:RSEC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RSEC_ECOLI PSORT2 swissprot:RSEC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RSEC_ECOLI Pfam PF04246 http://pfam.xfam.org/family/PF04246 Phobius swissprot:RSEC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RSEC_ECOLI ProteinModelPortal P46187 http://www.proteinmodelportal.org/query/uniprot/P46187 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7889935 http://www.ncbi.nlm.nih.gov/pubmed/7889935 PubMed 9159522 http://www.ncbi.nlm.nih.gov/pubmed/9159522 PubMed 9159523 http://www.ncbi.nlm.nih.gov/pubmed/9159523 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417065 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417065 RefSeq WP_000589068 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000589068 STRING 511145.b2570 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2570&targetmode=cogs STRING COG3086 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3086&targetmode=cogs UniProtKB RSEC_ECOLI http://www.uniprot.org/uniprot/RSEC_ECOLI UniProtKB-AC P46187 http://www.uniprot.org/uniprot/P46187 charge swissprot:RSEC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RSEC_ECOLI eggNOG COG3086 http://eggnogapi.embl.de/nog_data/html/tree/COG3086 eggNOG ENOG4105WMJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105WMJ epestfind swissprot:RSEC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RSEC_ECOLI garnier swissprot:RSEC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RSEC_ECOLI helixturnhelix swissprot:RSEC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RSEC_ECOLI hmoment swissprot:RSEC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RSEC_ECOLI iep swissprot:RSEC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RSEC_ECOLI inforesidue swissprot:RSEC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RSEC_ECOLI octanol swissprot:RSEC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RSEC_ECOLI pepcoil swissprot:RSEC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RSEC_ECOLI pepdigest swissprot:RSEC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RSEC_ECOLI pepinfo swissprot:RSEC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RSEC_ECOLI pepnet swissprot:RSEC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RSEC_ECOLI pepstats swissprot:RSEC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RSEC_ECOLI pepwheel swissprot:RSEC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RSEC_ECOLI pepwindow swissprot:RSEC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RSEC_ECOLI sigcleave swissprot:RSEC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RSEC_ECOLI ## Database ID URL or Descriptions # DrugBank DB00560 Tigecycline # EcoGene EG10912 rpsM # FUNCTION RS13_ECOLI Contacts the tRNAs in the A and P sites. {ECO 0000269|PubMed 15308780}. # FUNCTION RS13_ECOLI In the E.coli 70S ribosome in the initiation state (PubMed 12809609) was modeled to contact the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; bridge B1a is broken in the model with bound EF-G, while the protein-protein contacts between S13 and L5 in B1b change (PubMed 12809609). The 23S rRNA contact site in bridge B1a is modeled to differ in different ribosomal states (PubMed 16272117), contacting alternately S13 or S19. In the two 3.5 angstroms resolved ribosome structures (PubMed 12859903) the contacts between L5, S13 and S19 bridge B1b are different, confirming the dynamic nature of this interaction. Bridge B1a is not visible in the crystallized ribosomes due to 23S rRNA disorder. {ECO 0000269|PubMed 12809609, ECO 0000269|PubMed 12859903, ECO 0000269|PubMed 15308780, ECO 0000269|PubMed 16272117}. # FUNCTION RS13_ECOLI Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. {ECO 0000269|PubMed 15308780}. # FUNCTION RS13_ECOLI The C-terminal tail plays a role in the affinity of the 30S P site for different tRNAs. {ECO 0000269|PubMed 15308780}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0022627 cytosolic small ribosomal subunit; IDA:EcoliWiki. # GO_function GO:0000049 tRNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0003735 structural constituent of ribosome; IEA:InterPro. # GO_function GO:0019843 rRNA binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006412 translation; IBA:GO_Central. # GO_process GO:0042254 ribosome biogenesis; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_function GO:0019843 rRNA binding # GOslim_process GO:0006412 translation # GOslim_process GO:0042254 ribosome biogenesis # Gene3D 4.10.910.10 -; 1. # HAMAP MF_01315 Ribosomal_S13_S18 # IntAct P0A7S9 101 # InterPro IPR001892 Ribosomal_S13 # InterPro IPR010979 Ribosomal_S13-like_H2TH # InterPro IPR018269 Ribosomal_S13_CS # InterPro IPR019980 Ribosomal_S13_bac-type # InterPro IPR027437 30s_Rbsml_prot_S13_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 M00179 Ribosome, archaea # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=12968.1; Method=MALDI; Range=2-118; Evidence={ECO:0000269|PubMed 10094780}; # Organism RS13_ECOLI Escherichia coli (strain K12) # PATRIC 32122028 VBIEscCol129921_3391 # PDB 1M5G Model; -; M=2-118 # PDB 2YKR EM; 9.80 A; M=2-115 # PDB 3J9Y EM; 3.90 A; m=1-118 # PDB 3J9Z EM; 3.60 A; SM=2-118 # PDB 3JA1 EM; 3.60 A; SM=2-118 # PDB 3JBU EM; 3.64 A; M=1-118 # PDB 3JBV EM; 3.32 A; M=1-118 # PDB 3JCD EM; 3.70 A; m=1-118 # PDB 3JCE EM; 3.20 A; m=1-118 # PDB 3JCJ EM; 3.70 A; s=1-118 # PDB 3JCN EM; 4.60 A; n=1-118 # PDB 4A2I EM; 16.50 A; M=2-115 # PDB 4ADV EM; 13.50 A; M=2-118 # PDB 4U1U X-ray; 2.95 A; AM/CM=2-115 # PDB 4U1V X-ray; 3.00 A; AM/CM=2-115 # PDB 4U20 X-ray; 2.90 A; AM/CM=2-115 # PDB 4U24 X-ray; 2.90 A; AM/CM=2-115 # PDB 4U25 X-ray; 2.90 A; AM/CM=2-115 # PDB 4U26 X-ray; 2.80 A; AM/CM=2-115 # PDB 4U27 X-ray; 2.80 A; AM/CM=2-115 # PDB 4V47 EM; 12.30 A; BM=2-118 # PDB 4V48 EM; 11.50 A; BM=2-118 # PDB 4V4H X-ray; 3.46 A; AM/CM=1-118 # PDB 4V4Q X-ray; 3.46 A; AM/CM=2-118 # PDB 4V4V EM; 15.00 A; AM=2-116 # PDB 4V4W EM; 15.00 A; AM=2-116 # PDB 4V50 X-ray; 3.22 A; AM/CM=2-118 # PDB 4V52 X-ray; 3.21 A; AM/CM=2-118 # PDB 4V53 X-ray; 3.54 A; AM/CM=2-118 # PDB 4V54 X-ray; 3.30 A; AM/CM=2-118 # PDB 4V55 X-ray; 4.00 A; AM/CM=2-118 # PDB 4V56 X-ray; 3.93 A; AM/CM=2-118 # PDB 4V57 X-ray; 3.50 A; AM/CM=2-118 # PDB 4V5B X-ray; 3.74 A; BM/DM=2-118 # PDB 4V5H EM; 5.80 A; AM=2-114 # PDB 4V5Y X-ray; 4.45 A; AM/CM=2-118 # PDB 4V64 X-ray; 3.50 A; AM/CM=2-118 # PDB 4V65 EM; 9.00 A; AF=1-118 # PDB 4V66 EM; 9.00 A; AF=1-118 # PDB 4V69 EM; 6.70 A; AM=2-114 # PDB 4V6C X-ray; 3.19 A; AM/CM=1-118 # PDB 4V6D X-ray; 3.81 A; AM/CM=1-118 # PDB 4V6E X-ray; 3.71 A; AM/CM=1-118 # PDB 4V6K EM; 8.25 A; BQ=1-118 # PDB 4V6L EM; 13.20 A; AQ=1-118 # PDB 4V6N EM; 12.10 A; BP=2-118 # PDB 4V6O EM; 14.70 A; AP=2-118 # PDB 4V6P EM; 13.50 A; AP=2-118 # PDB 4V6Q EM; 11.50 A; AP=2-118 # PDB 4V6R EM; 11.50 A; AP=2-118 # PDB 4V6S EM; 13.10 A; BO=2-118 # PDB 4V6T EM; 8.30 A; AM=2-115 # PDB 4V6V EM; 9.80 A; AM=2-118 # PDB 4V6Y EM; 12.00 A; AM=1-114 # PDB 4V6Z EM; 12.00 A; AM=1-114 # PDB 4V70 EM; 17.00 A; AM=1-114 # PDB 4V71 EM; 20.00 A; AM=1-114 # PDB 4V72 EM; 13.00 A; AM=1-114 # PDB 4V73 EM; 15.00 A; AM=1-114 # PDB 4V74 EM; 17.00 A; AM=1-114 # PDB 4V75 EM; 12.00 A; AM=1-114 # PDB 4V76 EM; 17.00 A; AM=1-114 # PDB 4V77 EM; 17.00 A; AM=1-114 # PDB 4V78 EM; 20.00 A; AM=1-114 # PDB 4V79 EM; 15.00 A; AM=1-114 # PDB 4V7A EM; 9.00 A; AM=1-114 # PDB 4V7B EM; 6.80 A; AM=1-118 # PDB 4V7C EM; 7.60 A; AM=2-118 # PDB 4V7D EM; 7.60 A; BM=2-118 # PDB 4V7I EM; 9.60 A; BM=1-118 # PDB 4V7S X-ray; 3.25 A; AM=2-115, CM=2-114 # PDB 4V7T X-ray; 3.19 A; AM=2-115, CM=2-114 # PDB 4V7U X-ray; 3.10 A; AM/CM=2-115 # PDB 4V7V X-ray; 3.29 A; AM=2-115, CM=2-114 # PDB 4V85 X-ray; 3.20 A; M=1-118 # PDB 4V89 X-ray; 3.70 A; AM=1-118 # PDB 4V9C X-ray; 3.30 A; AM/CM=1-118 # PDB 4V9D X-ray; 3.00 A; AM/BM=2-115 # PDB 4V9O X-ray; 2.90 A; BM/DM/FM/HM=1-118 # PDB 4V9P X-ray; 2.90 A; BM/DM/FM/HM=1-118 # PDB 4WF1 X-ray; 3.09 A; AM/CM=2-115 # PDB 4WOI X-ray; 3.00 A; AM/DM=1-118 # PDB 4WWW X-ray; 3.10 A; QM/XM=2-115 # PDB 4YBB X-ray; 2.10 A; AM/BM=2-115 # PDB 5AFI EM; 2.90 A; m=1-118 # PDB 5IQR EM; 3.00 A; r=1-118 # PDB 5IT8 X-ray; 3.12 A; AM/BM=2-115 # PDB 5J5B X-ray; 2.80 A; AM/BM=2-115 # PDB 5J7L X-ray; 3.00 A; AM/BM=2-115 # PDB 5J88 X-ray; 3.32 A; AM/BM=2-115 # PDB 5J8A X-ray; 3.10 A; AM/BM=2-115 # PDB 5J91 X-ray; 2.96 A; AM/BM=2-115 # PDB 5JC9 X-ray; 3.03 A; AM/BM=2-115 # PDB 5JTE EM; 3.60 A; AM=1-118 # PDB 5JU8 EM; 3.60 A; AM=1-118 # PDB 5KCR EM; 3.60 A; 1m=1-118 # PDB 5KCS EM; 3.90 A; 1m=1-118 # PDB 5KPS EM; 3.90 A; 18=1-118 # PDB 5KPV EM; 4.10 A; 17=1-118 # PDB 5KPW EM; 3.90 A; 17=1-118 # PDB 5KPX EM; 3.90 A; 17=1-118 # PDB 5L3P EM; 3.70 A; m=1-118 # PIR A23807 R3EC13 # PIRSF PIRSF002134 Ribosomal_S13 # PROSITE PS00646 RIBOSOMAL_S13_1 # PROSITE PS50159 RIBOSOMAL_S13_2 # Pfam PF00416 Ribosomal_S13 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RS13_ECOLI 30S ribosomal protein S13 # RefSeq NP_417757 NC_000913.3 # RefSeq WP_000090775 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein S13P family. {ECO 0000305}. # SUBUNIT RS13_ECOLI Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Cross-links to the P site tRNA and weakly to the A site tRNA. Forms two bridges to the 50S subunit in the 70S ribosome, contacting the 16S rRNA and proteins S19 and L5. # SUPFAM SSF46946 SSF46946 # TIGRFAMs TIGR03631 uS13_bact # eggNOG COG0099 LUCA # eggNOG ENOG4108Z04 Bacteria BLAST swissprot:RS13_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RS13_ECOLI BioCyc ECOL316407:JW3260-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3260-MONOMER BioCyc EcoCyc:EG10912-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10912-MONOMER BioCyc MetaCyc:EG10912-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10912-MONOMER COG COG0099 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0099 DIP DIP-35855N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35855N DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1016/0092-8674(81)90185-9 http://dx.doi.org/10.1016/0092-8674(81)90185-9 DOI 10.1016/S0092-8674(03)00427-6 http://dx.doi.org/10.1016/S0092-8674(03)00427-6 DOI 10.1016/S0092-8674(03)00476-8 http://dx.doi.org/10.1016/S0092-8674(03)00476-8 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb841 http://dx.doi.org/10.1038/nsb841 DOI 10.1073/pnas.0405227101 http://dx.doi.org/10.1073/pnas.0405227101 DOI 10.1093/nar/13.11.3891 http://dx.doi.org/10.1093/nar/13.11.3891 DOI 10.1093/nar/23.22.4635 http://dx.doi.org/10.1093/nar/23.22.4635 DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB00560 http://www.drugbank.ca/drugs/DB00560 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M10213 http://www.ebi.ac.uk/ena/data/view/M10213 EMBL M12432 http://www.ebi.ac.uk/ena/data/view/M12432 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X02543 http://www.ebi.ac.uk/ena/data/view/X02543 EchoBASE EB0905 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0905 EcoGene EG10912 http://www.ecogene.org/geneInfo.php?eg_id=EG10912 EnsemblBacteria AAC76323 http://www.ensemblgenomes.org/id/AAC76323 EnsemblBacteria AAC76323 http://www.ensemblgenomes.org/id/AAC76323 EnsemblBacteria BAE77993 http://www.ensemblgenomes.org/id/BAE77993 EnsemblBacteria BAE77993 http://www.ensemblgenomes.org/id/BAE77993 EnsemblBacteria BAE77993 http://www.ensemblgenomes.org/id/BAE77993 EnsemblBacteria b3298 http://www.ensemblgenomes.org/id/b3298 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0022627 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022627 GO_function GO:0000049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000049 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GO_process GO:0042254 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042254 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_process GO:0042254 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042254 Gene3D 4.10.910.10 http://www.cathdb.info/version/latest/superfamily/4.10.910.10 GeneID 947791 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947791 HAMAP MF_01315 http://hamap.expasy.org/unirule/MF_01315 HOGENOM HOG000039879 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000039879&db=HOGENOM6 InParanoid P0A7S9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7S9 IntAct P0A7S9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7S9* InterPro IPR001892 http://www.ebi.ac.uk/interpro/entry/IPR001892 InterPro IPR010979 http://www.ebi.ac.uk/interpro/entry/IPR010979 InterPro IPR018269 http://www.ebi.ac.uk/interpro/entry/IPR018269 InterPro IPR019980 http://www.ebi.ac.uk/interpro/entry/IPR019980 InterPro IPR027437 http://www.ebi.ac.uk/interpro/entry/IPR027437 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW3260 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3260 KEGG_Gene eco:b3298 http://www.genome.jp/dbget-bin/www_bget?eco:b3298 KEGG_Orthology KO:K02952 http://www.genome.jp/dbget-bin/www_bget?KO:K02952 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 MINT MINT-1290225 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1290225 OMA RTKNNSR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RTKNNSR PDB 1M5G http://www.ebi.ac.uk/pdbe-srv/view/entry/1M5G PDB 2YKR http://www.ebi.ac.uk/pdbe-srv/view/entry/2YKR PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 4A2I http://www.ebi.ac.uk/pdbe-srv/view/entry/4A2I PDB 4ADV http://www.ebi.ac.uk/pdbe-srv/view/entry/4ADV PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4V47 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V47 PDB 4V48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V48 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 1M5G http://www.ebi.ac.uk/pdbsum/1M5G PDBsum 2YKR http://www.ebi.ac.uk/pdbsum/2YKR PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 4A2I http://www.ebi.ac.uk/pdbsum/4A2I PDBsum 4ADV http://www.ebi.ac.uk/pdbsum/4ADV PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4V47 http://www.ebi.ac.uk/pdbsum/4V47 PDBsum 4V48 http://www.ebi.ac.uk/pdbsum/4V48 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PROSITE PS00646 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00646 PROSITE PS50159 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50159 PSORT swissprot:RS13_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RS13_ECOLI PSORT-B swissprot:RS13_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RS13_ECOLI PSORT2 swissprot:RS13_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RS13_ECOLI Pfam PF00416 http://pfam.xfam.org/family/PF00416 Phobius swissprot:RS13_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RS13_ECOLI PhylomeDB P0A7S9 http://phylomedb.org/?seqid=P0A7S9 ProteinModelPortal P0A7S9 http://www.proteinmodelportal.org/query/uniprot/P0A7S9 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 12244297 http://www.ncbi.nlm.nih.gov/pubmed/12244297 PubMed 12809609 http://www.ncbi.nlm.nih.gov/pubmed/12809609 PubMed 12859903 http://www.ncbi.nlm.nih.gov/pubmed/12859903 PubMed 15308780 http://www.ncbi.nlm.nih.gov/pubmed/15308780 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2989779 http://www.ncbi.nlm.nih.gov/pubmed/2989779 PubMed 3279034 http://www.ncbi.nlm.nih.gov/pubmed/3279034 PubMed 330375 http://www.ncbi.nlm.nih.gov/pubmed/330375 PubMed 6154696 http://www.ncbi.nlm.nih.gov/pubmed/6154696 PubMed 6793240 http://www.ncbi.nlm.nih.gov/pubmed/6793240 PubMed 8193163 http://www.ncbi.nlm.nih.gov/pubmed/8193163 PubMed 8524654 http://www.ncbi.nlm.nih.gov/pubmed/8524654 PubMed 9226267 http://www.ncbi.nlm.nih.gov/pubmed/9226267 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417757 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417757 RefSeq WP_000090775 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000090775 SMR P0A7S9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7S9 STRING 511145.b3298 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3298&targetmode=cogs STRING COG0099 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0099&targetmode=cogs SUPFAM SSF46946 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46946 TIGRFAMs TIGR03631 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03631 UniProtKB RS13_ECOLI http://www.uniprot.org/uniprot/RS13_ECOLI UniProtKB-AC P0A7S9 http://www.uniprot.org/uniprot/P0A7S9 charge swissprot:RS13_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RS13_ECOLI eggNOG COG0099 http://eggnogapi.embl.de/nog_data/html/tree/COG0099 eggNOG ENOG4108Z04 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Z04 epestfind swissprot:RS13_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RS13_ECOLI garnier swissprot:RS13_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RS13_ECOLI helixturnhelix swissprot:RS13_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RS13_ECOLI hmoment swissprot:RS13_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RS13_ECOLI iep swissprot:RS13_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RS13_ECOLI inforesidue swissprot:RS13_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RS13_ECOLI octanol swissprot:RS13_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RS13_ECOLI pepcoil swissprot:RS13_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RS13_ECOLI pepdigest swissprot:RS13_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RS13_ECOLI pepinfo swissprot:RS13_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RS13_ECOLI pepnet swissprot:RS13_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RS13_ECOLI pepstats swissprot:RS13_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RS13_ECOLI pepwheel swissprot:RS13_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RS13_ECOLI pepwindow swissprot:RS13_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RS13_ECOLI sigcleave swissprot:RS13_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RS13_ECOLI ## Database ID URL or Descriptions # BioGrid 4261313 6 # EcoGene EG13468 yphG # Gene3D 1.25.40.10 -; 3. # InterPro IPR011990 TPR-like_helical_dom # InterPro IPR013026 TPR-contain_dom # InterPro IPR019734 TPR_repeat # InterPro IPR033396 DUF5107 # Organism YPHG_ECOLI Escherichia coli (strain K12) # PATRIC 32120495 VBIEscCol129921_2650 # PIR D65032 D65032 # PROSITE PS50293 TPR_REGION; 2 # Pfam PF13181 TPR_8 # Pfam PF17128 DUF5107 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YPHG_ECOLI Uncharacterized protein YphG # RefSeq NP_417044 NC_000913.3 # RefSeq WP_001333903 NZ_LN832404.1 # SMART SM00028 TPR; 5 # SUPFAM SSF48452 SSF48452; 4 # eggNOG ENOG4107HQ7 Bacteria # eggNOG ENOG410Z39P LUCA BLAST swissprot:YPHG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YPHG_ECOLI BioCyc ECOL316407:JW5405-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5405-MONOMER BioCyc EcoCyc:G7343-MONOMER http://biocyc.org/getid?id=EcoCyc:G7343-MONOMER DIP DIP-12832N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12832N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3241 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3241 EcoGene EG13468 http://www.ecogene.org/geneInfo.php?eg_id=EG13468 EnsemblBacteria AAC75602 http://www.ensemblgenomes.org/id/AAC75602 EnsemblBacteria AAC75602 http://www.ensemblgenomes.org/id/AAC75602 EnsemblBacteria BAE76731 http://www.ensemblgenomes.org/id/BAE76731 EnsemblBacteria BAE76731 http://www.ensemblgenomes.org/id/BAE76731 EnsemblBacteria BAE76731 http://www.ensemblgenomes.org/id/BAE76731 EnsemblBacteria b2549 http://www.ensemblgenomes.org/id/b2549 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 1.25.40.10 http://www.cathdb.info/version/latest/superfamily/1.25.40.10 GeneID 947021 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947021 HOGENOM HOG000123492 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000123492&db=HOGENOM6 InParanoid P76585 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76585 InterPro IPR011990 http://www.ebi.ac.uk/interpro/entry/IPR011990 InterPro IPR013026 http://www.ebi.ac.uk/interpro/entry/IPR013026 InterPro IPR019734 http://www.ebi.ac.uk/interpro/entry/IPR019734 InterPro IPR033396 http://www.ebi.ac.uk/interpro/entry/IPR033396 KEGG_Gene ecj:JW5405 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5405 KEGG_Gene eco:b2549 http://www.genome.jp/dbget-bin/www_bget?eco:b2549 OMA QYRHATY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QYRHATY PROSITE PS50293 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50293 PSORT swissprot:YPHG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YPHG_ECOLI PSORT-B swissprot:YPHG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YPHG_ECOLI PSORT2 swissprot:YPHG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YPHG_ECOLI Pfam PF13181 http://pfam.xfam.org/family/PF13181 Pfam PF17128 http://pfam.xfam.org/family/PF17128 Phobius swissprot:YPHG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YPHG_ECOLI PhylomeDB P76585 http://phylomedb.org/?seqid=P76585 ProteinModelPortal P76585 http://www.proteinmodelportal.org/query/uniprot/P76585 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417044 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417044 RefSeq WP_001333903 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001333903 SMART SM00028 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00028 STRING 511145.b2549 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2549&targetmode=cogs SUPFAM SSF48452 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48452 UniProtKB YPHG_ECOLI http://www.uniprot.org/uniprot/YPHG_ECOLI UniProtKB-AC P76585 http://www.uniprot.org/uniprot/P76585 charge swissprot:YPHG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YPHG_ECOLI eggNOG ENOG4107HQ7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107HQ7 eggNOG ENOG410Z39P http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Z39P epestfind swissprot:YPHG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YPHG_ECOLI garnier swissprot:YPHG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YPHG_ECOLI helixturnhelix swissprot:YPHG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YPHG_ECOLI hmoment swissprot:YPHG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YPHG_ECOLI iep swissprot:YPHG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YPHG_ECOLI inforesidue swissprot:YPHG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YPHG_ECOLI octanol swissprot:YPHG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YPHG_ECOLI pepcoil swissprot:YPHG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YPHG_ECOLI pepdigest swissprot:YPHG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YPHG_ECOLI pepinfo swissprot:YPHG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YPHG_ECOLI pepnet swissprot:YPHG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YPHG_ECOLI pepstats swissprot:YPHG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YPHG_ECOLI pepwheel swissprot:YPHG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YPHG_ECOLI pepwindow swissprot:YPHG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YPHG_ECOLI sigcleave swissprot:YPHG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YPHG_ECOLI ## Database ID URL or Descriptions # AltName DPAL_ECOLI 2,3-diaminopropionate ammonia-lyase # AltName DPAL_ECOLI Alpha,beta-diaminopropionate ammonia-lyase # AltName DPAL_ECOLI Diaminopropionatase # BIOPHYSICOCHEMICAL PROPERTIES DPAL_ECOLI Kinetic parameters KM=0.10 mM for D-DAP {ECO 0000269|PubMed 12596860}; KM=0.048 mM for L-DAP {ECO 0000269|PubMed 12596860}; Vmax=48 umol/min/mg enzyme for D-DAP {ECO 0000269|PubMed 12596860}; Vmax=25 umol/min/mg enzyme for L-DAP {ECO 0000269|PubMed 12596860}; pH dependence Optimum pH is 8.0. {ECO 0000269|PubMed 12596860}; # BioGrid 4262322 13 # CATALYTIC ACTIVITY 2,3-diaminopropionate + H(2)O = pyruvate + 2 NH(3). {ECO:0000269|PubMed 12596860}. # COFACTOR DPAL_ECOLI Name=pyridoxal 5'-phosphate; Xref=ChEBI CHEBI 597326; Evidence={ECO 0000269|PubMed 12821154, ECO 0000269|PubMed 22505717}; Note=Binds 1 pyridoxal phosphate per subunit. {ECO 0000269|PubMed 12821154, ECO 0000269|PubMed 22505717}; # DISRUPTION PHENOTYPE No growth on minimal medium plus DL-DAP; growth can be restored by a mix of 8 amino acids (Arg, Asn, Cys, Glu, Ile, Leu, Met and Thr). {ECO:0000269|PubMed 22904288}. # EcoGene EG13054 ygeX # FUNCTION DPAL_ECOLI Catalyzes the alpha,beta-elimination reaction of both L- and D-alpha,beta-diaminopropionate (DAP) to form pyruvate and ammonia. In vitro the D-isomer of serine is degraded to pyruvate, though very poorly; other amino acids (L-serine, D- and L- threonine, D- and L-beta-Cl-alanine) are not substrates. In vivo allows poor growth on L-DAP or a DL-DAP mixture but not on D-DAP alone, this may be due to a poor promoter. DL-DAP is toxic in the absence of this enzyme, it may inhibit enzymes involved in the synthesis of pyruvate and aspartate, as well as amino acids derived from them. {ECO 0000269|PubMed 12596860, ECO 0000269|PubMed 12821154, ECO 0000269|PubMed 22505717, ECO 0000269|PubMed 22904288}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0008838 diaminopropionate ammonia-lyase activity; IDA:EcoCyc. # GO_function GO:0030170 pyridoxal phosphate binding; IDA:EcoCyc. # GO_process GO:0009063 cellular amino acid catabolic process; ISA:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # INDUCTION Slightly induced by DL-DAP. {ECO:0000269|PubMed 22904288}. # InterPro IPR001926 TrpB-like_PLP-dep # InterPro IPR010081 DiNH2opropionate_NH3_lyase # InterPro IPR019871 DiNH2propionate_NH3-lyase_sub # KEGG_Brite ko01000 Enzymes # Organism DPAL_ECOLI Escherichia coli (strain K12) # PATRIC 32121152 VBIEscCol129921_2964 # PDB 4D9G X-ray; 2.45 A; A/B=1-398 # PDB 4D9I X-ray; 2.00 A; A/B=1-398 # PDB 4D9K X-ray; 2.19 A; A/B/C/D=1-398 # PDB 4D9M X-ray; 2.50 A; A/B=1-398 # PDB 4D9N X-ray; 2.50 A; A/B=1-398 # PIR G65070 G65070 # Pfam PF00291 PALP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DPAL_ECOLI Diaminopropionate ammonia-lyase # RefSeq NP_417347 NC_000913.3 # RefSeq WP_000110493 NZ_LN832404.1 # SIMILARITY Belongs to the diaminopropionate ammonia-lyase family. {ECO 0000305}. # SUBUNIT DPAL_ECOLI Homodimer. {ECO 0000305|PubMed 12596860, ECO 0000305|PubMed 12821154, ECO 0000305|PubMed 22505717}. # SUPFAM SSF53686 SSF53686 # TIGRFAMs TIGR01747 diampropi_NH3ly # TIGRFAMs TIGR03528 2_3_DAP_am_ly # eggNOG COG1171 LUCA # eggNOG ENOG4107RCH Bacteria BLAST swissprot:DPAL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DPAL_ECOLI BioCyc ECOL316407:JW2839-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2839-MONOMER BioCyc EcoCyc:G7490-MONOMER http://biocyc.org/getid?id=EcoCyc:G7490-MONOMER BioCyc MetaCyc:G7490-MONOMER http://biocyc.org/getid?id=MetaCyc:G7490-MONOMER COG COG1171 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1171 DOI 10.1016/S0006-291X(03)01100-8 http://dx.doi.org/10.1016/S0006-291X(03)01100-8 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M112.351809 http://dx.doi.org/10.1074/jbc.M112.351809 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01362-12 http://dx.doi.org/10.1128/JB.01362-12 DOI 10.1271/bbb.66.2639 http://dx.doi.org/10.1271/bbb.66.2639 EC_number EC:4.3.1.15 http://www.genome.jp/dbget-bin/www_bget?EC:4.3.1.15 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 ENZYME 4.3.1.15 http://enzyme.expasy.org/EC/4.3.1.15 EchoBASE EB2866 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2866 EcoGene EG13054 http://www.ecogene.org/geneInfo.php?eg_id=EG13054 EnsemblBacteria AAC75909 http://www.ensemblgenomes.org/id/AAC75909 EnsemblBacteria AAC75909 http://www.ensemblgenomes.org/id/AAC75909 EnsemblBacteria BAE76937 http://www.ensemblgenomes.org/id/BAE76937 EnsemblBacteria BAE76937 http://www.ensemblgenomes.org/id/BAE76937 EnsemblBacteria BAE76937 http://www.ensemblgenomes.org/id/BAE76937 EnsemblBacteria b2871 http://www.ensemblgenomes.org/id/b2871 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0008838 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008838 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_process GO:0009063 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009063 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GeneID 947012 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947012 HOGENOM HOG000220594 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220594&db=HOGENOM6 InParanoid P66899 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P66899 IntAct P66899 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P66899* IntEnz 4.3.1.15 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.3.1.15 InterPro IPR001926 http://www.ebi.ac.uk/interpro/entry/IPR001926 InterPro IPR010081 http://www.ebi.ac.uk/interpro/entry/IPR010081 InterPro IPR019871 http://www.ebi.ac.uk/interpro/entry/IPR019871 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2839 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2839 KEGG_Gene eco:b2871 http://www.genome.jp/dbget-bin/www_bget?eco:b2871 KEGG_Orthology KO:K01751 http://www.genome.jp/dbget-bin/www_bget?KO:K01751 OMA SVVYMPK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SVVYMPK PDB 4D9G http://www.ebi.ac.uk/pdbe-srv/view/entry/4D9G PDB 4D9I http://www.ebi.ac.uk/pdbe-srv/view/entry/4D9I PDB 4D9K http://www.ebi.ac.uk/pdbe-srv/view/entry/4D9K PDB 4D9M http://www.ebi.ac.uk/pdbe-srv/view/entry/4D9M PDB 4D9N http://www.ebi.ac.uk/pdbe-srv/view/entry/4D9N PDBsum 4D9G http://www.ebi.ac.uk/pdbsum/4D9G PDBsum 4D9I http://www.ebi.ac.uk/pdbsum/4D9I PDBsum 4D9K http://www.ebi.ac.uk/pdbsum/4D9K PDBsum 4D9M http://www.ebi.ac.uk/pdbsum/4D9M PDBsum 4D9N http://www.ebi.ac.uk/pdbsum/4D9N PSORT swissprot:DPAL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DPAL_ECOLI PSORT-B swissprot:DPAL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DPAL_ECOLI PSORT2 swissprot:DPAL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DPAL_ECOLI Pfam PF00291 http://pfam.xfam.org/family/PF00291 Phobius swissprot:DPAL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DPAL_ECOLI PhylomeDB P66899 http://phylomedb.org/?seqid=P66899 ProteinModelPortal P66899 http://www.proteinmodelportal.org/query/uniprot/P66899 PubMed 12596860 http://www.ncbi.nlm.nih.gov/pubmed/12596860 PubMed 12821154 http://www.ncbi.nlm.nih.gov/pubmed/12821154 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22505717 http://www.ncbi.nlm.nih.gov/pubmed/22505717 PubMed 22904288 http://www.ncbi.nlm.nih.gov/pubmed/22904288 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417347 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417347 RefSeq WP_000110493 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000110493 SMR P66899 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P66899 STRING 511145.b2871 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2871&targetmode=cogs STRING COG1171 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1171&targetmode=cogs SUPFAM SSF53686 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53686 TIGRFAMs TIGR01747 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01747 TIGRFAMs TIGR03528 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03528 UniProtKB DPAL_ECOLI http://www.uniprot.org/uniprot/DPAL_ECOLI UniProtKB-AC P66899 http://www.uniprot.org/uniprot/P66899 charge swissprot:DPAL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DPAL_ECOLI eggNOG COG1171 http://eggnogapi.embl.de/nog_data/html/tree/COG1171 eggNOG ENOG4107RCH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107RCH epestfind swissprot:DPAL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DPAL_ECOLI garnier swissprot:DPAL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DPAL_ECOLI helixturnhelix swissprot:DPAL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DPAL_ECOLI hmoment swissprot:DPAL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DPAL_ECOLI iep swissprot:DPAL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DPAL_ECOLI inforesidue swissprot:DPAL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DPAL_ECOLI octanol swissprot:DPAL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DPAL_ECOLI pepcoil swissprot:DPAL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DPAL_ECOLI pepdigest swissprot:DPAL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DPAL_ECOLI pepinfo swissprot:DPAL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DPAL_ECOLI pepnet swissprot:DPAL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DPAL_ECOLI pepstats swissprot:DPAL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DPAL_ECOLI pepwheel swissprot:DPAL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DPAL_ECOLI pepwindow swissprot:DPAL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DPAL_ECOLI sigcleave swissprot:DPAL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DPAL_ECOLI ## Database ID URL or Descriptions # AltName ATP GTP 3'-pyrophosphotransferase # AltName RELA_ECOLI (p)ppGpp synthase # AltName RELA_ECOLI ppGpp synthase I # BioGrid 4259226 12 # CATALYTIC ACTIVITY RELA_ECOLI ATP + GTP = AMP + guanosine 3'-diphosphate 5'- triphosphate. # CDD cd01668 TGS_RelA_SpoT # CDD cd05399 NT_Rel-Spo_like # DISRUPTION PHENOTYPE RELA_ECOLI A slight increase in biofilm formation in a csrA-disrupted background; when combined with a spoT disruption (a ppGpp0 mutant) there is a very large increase in biofilm formation (PubMed 19460094). Deletion of relA alone decreases persister cell formation in a hipA7 mutant; the double relA/spoT deletion obviates persister cell formation (PubMed 14622409, PubMed 26051177). {ECO 0000269|PubMed 14622409, ECO 0000269|PubMed 19460094, ECO 0000269|PubMed 26051177}. # EcoGene EG10835 relA # FUNCTION RELA_ECOLI In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp. {ECO 0000269|PubMed 14622409, ECO 0000269|PubMed 19460094, ECO 0000269|PubMed 26051177}. # GO_component GO:0005618 cell wall; IBA:GO_Central. # GO_component GO:0005886 plasma membrane; IBA:GO_Central. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0005525 GTP binding; IEA:UniProtKB-KW. # GO_function GO:0008728 GTP diphosphokinase activity; IDA:EcoCyc. # GO_function GO:0008893 guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity; IBA:GO_Central. # GO_function GO:0016301 kinase activity; IEA:UniProtKB-KW. # GO_function GO:0016597 amino acid binding; IEA:InterPro. # GO_process GO:0015949 nucleobase-containing small molecule interconversion; IDA:EcoCyc. # GO_process GO:0015969 guanosine tetraphosphate metabolic process; IMP:EcoCyc. # GO_process GO:0015970 guanosine tetraphosphate biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0042594 response to starvation; IBA:GO_Central. # GOslim_component GO:0005618 cell wall # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.10.20.30 -; 1. # IntAct P0AG20 15 # InterPro IPR002912 ACT_dom # InterPro IPR003607 HD/PDEase_dom # InterPro IPR004095 TGS # InterPro IPR004811 RelA/Spo_fam # InterPro IPR007685 RelA_SpoT # InterPro IPR012675 Beta-grasp_dom # InterPro IPR012676 TGS-like # InterPro IPR033655 TGS_RelA # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # Organism RELA_ECOLI Escherichia coli (strain K12) # PATHWAY Purine metabolism; ppGpp biosynthesis; ppGpp from GTP step 1/2. # PATRIC 32120984 VBIEscCol129921_2884 # PDB 5IQR EM; 3.00 A; 8=1-744 # PDB 5KPS EM; 3.90 A; A=2-744 # PDB 5KPV EM; 4.10 A; 33=2-744 # PDB 5KPW EM; 3.90 A; 33=2-744 # PDB 5KPX EM; 3.90 A; 33=2-744 # PDB 5L3P EM; 3.70 A; z=1-744 # PIR D65060 KIECG # PROSITE PS51671 ACT # Pfam PF02824 TGS # Pfam PF04607 RelA_SpoT # Pfam PF13291 ACT_4 # Pfam PF13328 HD_4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RELA_ECOLI GTP pyrophosphokinase # RefSeq NP_417264 NC_000913.3 # RefSeq WP_000226815 NZ_LN832404.1 # SIMILARITY Belongs to the RelA/SpoT family. {ECO 0000305}. # SIMILARITY Contains 1 ACT domain. {ECO:0000255|PROSITE- ProRule PRU01007}. # SMART SM00954 RelA_SpoT # SUPFAM SSF81271 SSF81271 # TIGRFAMs TIGR00691 spoT_relA # UniPathway UPA00908 UER00884 # eggNOG COG0317 LUCA # eggNOG ENOG4105CWR Bacteria BLAST swissprot:RELA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RELA_ECOLI BioCyc ECOL316407:JW2755-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2755-MONOMER BioCyc EcoCyc:RELA-MONOMER http://biocyc.org/getid?id=EcoCyc:RELA-MONOMER BioCyc MetaCyc:RELA-MONOMER http://biocyc.org/getid?id=MetaCyc:RELA-MONOMER COG COG0317 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0317 DIP DIP-10658N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10658N DOI 10.1016/j.molcel.2015.05.011 http://dx.doi.org/10.1016/j.molcel.2015.05.011 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2003.03779.x http://dx.doi.org/10.1046/j.1365-2958.2003.03779.x DOI 10.1111/j.1365-2958.2009.06739.x http://dx.doi.org/10.1111/j.1365-2958.2009.06739.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.6.5 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.6.5 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J04039 http://www.ebi.ac.uk/ena/data/view/J04039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29580 http://www.ebi.ac.uk/ena/data/view/U29580 ENZYME 2.7.6.5 http://enzyme.expasy.org/EC/2.7.6.5 EchoBASE EB0828 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0828 EcoGene EG10835 http://www.ecogene.org/geneInfo.php?eg_id=EG10835 EnsemblBacteria AAC75826 http://www.ensemblgenomes.org/id/AAC75826 EnsemblBacteria AAC75826 http://www.ensemblgenomes.org/id/AAC75826 EnsemblBacteria BAE76858 http://www.ensemblgenomes.org/id/BAE76858 EnsemblBacteria BAE76858 http://www.ensemblgenomes.org/id/BAE76858 EnsemblBacteria BAE76858 http://www.ensemblgenomes.org/id/BAE76858 EnsemblBacteria b2784 http://www.ensemblgenomes.org/id/b2784 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005618 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_function GO:0008728 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008728 GO_function GO:0008893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008893 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_function GO:0016597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016597 GO_process GO:0015949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015949 GO_process GO:0015969 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015969 GO_process GO:0015970 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015970 GO_process GO:0042594 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042594 GOslim_component GO:0005618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005618 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.10.20.30 http://www.cathdb.info/version/latest/superfamily/3.10.20.30 GeneID 947244 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947244 HOGENOM HOG000018300 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000018300&db=HOGENOM6 InParanoid P0AG20 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AG20 IntAct P0AG20 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AG20* IntEnz 2.7.6.5 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.6.5 InterPro IPR002912 http://www.ebi.ac.uk/interpro/entry/IPR002912 InterPro IPR003607 http://www.ebi.ac.uk/interpro/entry/IPR003607 InterPro IPR004095 http://www.ebi.ac.uk/interpro/entry/IPR004095 InterPro IPR004811 http://www.ebi.ac.uk/interpro/entry/IPR004811 InterPro IPR007685 http://www.ebi.ac.uk/interpro/entry/IPR007685 InterPro IPR012675 http://www.ebi.ac.uk/interpro/entry/IPR012675 InterPro IPR012676 http://www.ebi.ac.uk/interpro/entry/IPR012676 InterPro IPR033655 http://www.ebi.ac.uk/interpro/entry/IPR033655 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2755 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2755 KEGG_Gene eco:b2784 http://www.genome.jp/dbget-bin/www_bget?eco:b2784 KEGG_Orthology KO:K00951 http://www.genome.jp/dbget-bin/www_bget?KO:K00951 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Reaction rn:R00429 http://www.genome.jp/dbget-bin/www_bget?rn:R00429 OMA TEIGHNC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TEIGHNC PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PROSITE PS51671 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51671 PSORT swissprot:RELA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RELA_ECOLI PSORT-B swissprot:RELA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RELA_ECOLI PSORT2 swissprot:RELA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RELA_ECOLI Pfam PF02824 http://pfam.xfam.org/family/PF02824 Pfam PF04607 http://pfam.xfam.org/family/PF04607 Pfam PF13291 http://pfam.xfam.org/family/PF13291 Pfam PF13328 http://pfam.xfam.org/family/PF13328 Phobius swissprot:RELA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RELA_ECOLI PhylomeDB P0AG20 http://phylomedb.org/?seqid=P0AG20 ProteinModelPortal P0AG20 http://www.proteinmodelportal.org/query/uniprot/P0AG20 PubMed 14622409 http://www.ncbi.nlm.nih.gov/pubmed/14622409 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19460094 http://www.ncbi.nlm.nih.gov/pubmed/19460094 PubMed 26051177 http://www.ncbi.nlm.nih.gov/pubmed/26051177 PubMed 2844820 http://www.ncbi.nlm.nih.gov/pubmed/2844820 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417264 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417264 RefSeq WP_000226815 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000226815 SMART SM00954 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00954 SMR P0AG20 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AG20 STRING 511145.b2784 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2784&targetmode=cogs STRING COG0317 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0317&targetmode=cogs SUPFAM SSF81271 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81271 TIGRFAMs TIGR00691 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00691 UniProtKB RELA_ECOLI http://www.uniprot.org/uniprot/RELA_ECOLI UniProtKB-AC P0AG20 http://www.uniprot.org/uniprot/P0AG20 charge swissprot:RELA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RELA_ECOLI eggNOG COG0317 http://eggnogapi.embl.de/nog_data/html/tree/COG0317 eggNOG ENOG4105CWR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CWR epestfind swissprot:RELA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RELA_ECOLI garnier swissprot:RELA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RELA_ECOLI helixturnhelix swissprot:RELA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RELA_ECOLI hmoment swissprot:RELA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RELA_ECOLI iep swissprot:RELA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RELA_ECOLI inforesidue swissprot:RELA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RELA_ECOLI octanol swissprot:RELA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RELA_ECOLI pepcoil swissprot:RELA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RELA_ECOLI pepdigest swissprot:RELA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RELA_ECOLI pepinfo swissprot:RELA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RELA_ECOLI pepnet swissprot:RELA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RELA_ECOLI pepstats swissprot:RELA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RELA_ECOLI pepwheel swissprot:RELA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RELA_ECOLI pepwindow swissprot:RELA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RELA_ECOLI sigcleave swissprot:RELA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RELA_ECOLI ## Database ID URL or Descriptions # AltName TYRP_ECOLI Tyrosine permease # BioGrid 4262055 7 # EcoGene EG11041 tyrP # FUNCTION TYRP_ECOLI Involved in transporting tyrosine across the cytoplasmic membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoliWiki. # GO_function GO:0015173 aromatic amino acid transmembrane transporter activity; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # INDUCTION TYRP_ECOLI Repressed by tyrosine and induced by phenylalanine under the control of regulatory protein TyrR. # InterPro IPR002091 ArAA_permease # InterPro IPR013059 Trp_tyr_transpt # InterPro IPR013061 Trp/try_permease_CS # InterPro IPR018227 Tryptophan/tyrosine_permease # KEGG_Brite ko02000 Transporters # Organism TYRP_ECOLI Escherichia coli (strain K12) # PATRIC 32119145 VBIEscCol129921_1990 # PIR C64954 GRECY # PRINTS PR00166 AROAAPRMEASE # PROSITE PS00594 AROMATIC_AA_PERMEASE_1 # Pfam PF03222 Trp_Tyr_perm # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TYRP_ECOLI Tyrosine-specific transport protein # RefSeq NP_416420 NC_000913.3 # RefSeq WP_000797560 NZ_LN832404.1 # SIMILARITY Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION TYRP_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.42.1 the hydroxy/aromatic amino acid permease (haaap) family # TIGRFAMs TIGR00837 araaP # eggNOG COG0814 LUCA # eggNOG ENOG4105E0U Bacteria BLAST swissprot:TYRP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TYRP_ECOLI BioCyc ECOL316407:JW1895-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1895-MONOMER BioCyc EcoCyc:TYRP-MONOMER http://biocyc.org/getid?id=EcoCyc:TYRP-MONOMER COG COG0814 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0814 DIP DIP-48105N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48105N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M23240 http://www.ebi.ac.uk/ena/data/view/M23240 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1034 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1034 EcoGene EG11041 http://www.ecogene.org/geneInfo.php?eg_id=EG11041 EnsemblBacteria AAC74977 http://www.ensemblgenomes.org/id/AAC74977 EnsemblBacteria AAC74977 http://www.ensemblgenomes.org/id/AAC74977 EnsemblBacteria BAA15730 http://www.ensemblgenomes.org/id/BAA15730 EnsemblBacteria BAA15730 http://www.ensemblgenomes.org/id/BAA15730 EnsemblBacteria BAA15730 http://www.ensemblgenomes.org/id/BAA15730 EnsemblBacteria b1907 http://www.ensemblgenomes.org/id/b1907 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015173 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015173 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GeneID 946412 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946412 HOGENOM HOG000269673 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000269673&db=HOGENOM6 InParanoid P0AAD4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAD4 IntAct P0AAD4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAD4* InterPro IPR002091 http://www.ebi.ac.uk/interpro/entry/IPR002091 InterPro IPR013059 http://www.ebi.ac.uk/interpro/entry/IPR013059 InterPro IPR013061 http://www.ebi.ac.uk/interpro/entry/IPR013061 InterPro IPR018227 http://www.ebi.ac.uk/interpro/entry/IPR018227 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1895 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1895 KEGG_Gene eco:b1907 http://www.genome.jp/dbget-bin/www_bget?eco:b1907 KEGG_Orthology KO:K03834 http://www.genome.jp/dbget-bin/www_bget?KO:K03834 MINT MINT-1305835 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1305835 OMA ALLMPHI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ALLMPHI PRINTS PR00166 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00166 PROSITE PS00594 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00594 PSORT swissprot:TYRP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TYRP_ECOLI PSORT-B swissprot:TYRP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TYRP_ECOLI PSORT2 swissprot:TYRP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TYRP_ECOLI Pfam PF03222 http://pfam.xfam.org/family/PF03222 Phobius swissprot:TYRP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TYRP_ECOLI PhylomeDB P0AAD4 http://phylomedb.org/?seqid=P0AAD4 ProteinModelPortal P0AAD4 http://www.proteinmodelportal.org/query/uniprot/P0AAD4 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3049553 http://www.ncbi.nlm.nih.gov/pubmed/3049553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416420 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416420 RefSeq WP_000797560 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000797560 STRING 511145.b1907 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1907&targetmode=cogs STRING COG0814 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0814&targetmode=cogs TCDB 2.A.42.1 http://www.tcdb.org/search/result.php?tc=2.A.42.1 TIGRFAMs TIGR00837 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00837 UniProtKB TYRP_ECOLI http://www.uniprot.org/uniprot/TYRP_ECOLI UniProtKB-AC P0AAD4 http://www.uniprot.org/uniprot/P0AAD4 charge swissprot:TYRP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TYRP_ECOLI eggNOG COG0814 http://eggnogapi.embl.de/nog_data/html/tree/COG0814 eggNOG ENOG4105E0U http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E0U epestfind swissprot:TYRP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TYRP_ECOLI garnier swissprot:TYRP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TYRP_ECOLI helixturnhelix swissprot:TYRP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TYRP_ECOLI hmoment swissprot:TYRP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TYRP_ECOLI iep swissprot:TYRP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TYRP_ECOLI inforesidue swissprot:TYRP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TYRP_ECOLI octanol swissprot:TYRP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TYRP_ECOLI pepcoil swissprot:TYRP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TYRP_ECOLI pepdigest swissprot:TYRP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TYRP_ECOLI pepinfo swissprot:TYRP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TYRP_ECOLI pepnet swissprot:TYRP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TYRP_ECOLI pepstats swissprot:TYRP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TYRP_ECOLI pepwheel swissprot:TYRP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TYRP_ECOLI pepwindow swissprot:TYRP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TYRP_ECOLI sigcleave swissprot:TYRP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TYRP_ECOLI ## Database ID URL or Descriptions # BioGrid 4261015 8 # EcoGene EG12510 ytfJ # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GOslim_component GO:0005575 cellular_component # InterPro IPR006513 CHP01626_YtfJ # Organism YTFJ_ECOLI Escherichia coli (strain K12) # PATRIC 32124007 VBIEscCol129921_4348 # PIR S56441 S56441 # Pfam PF09695 YtfJ_HI0045 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YTFJ_ECOLI Uncharacterized protein YtfJ # RefSeq NP_418637 NC_000913.3 # RefSeq WP_000175279 NZ_LN832404.1 # SIMILARITY To H.influenzae HI_0045. {ECO 0000305}. # SUBCELLULAR LOCATION YTFJ_ECOLI Periplasm {ECO 0000305}. # TIGRFAMs TIGR01626 ytfJ_HI0045 # eggNOG COG3054 LUCA # eggNOG ENOG4108UUE Bacteria BLAST swissprot:YTFJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YTFJ_ECOLI BioCyc ECOL316407:JW4175-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4175-MONOMER BioCyc EcoCyc:G7871-MONOMER http://biocyc.org/getid?id=EcoCyc:G7871-MONOMER COG COG3054 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3054 DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1271/bbb.58.117 http://dx.doi.org/10.1271/bbb.58.117 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D21142 http://www.ebi.ac.uk/ena/data/view/D21142 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2403 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2403 EcoGene EG12510 http://www.ecogene.org/geneInfo.php?eg_id=EG12510 EnsemblBacteria AAC77173 http://www.ensemblgenomes.org/id/AAC77173 EnsemblBacteria AAC77173 http://www.ensemblgenomes.org/id/AAC77173 EnsemblBacteria BAE78217 http://www.ensemblgenomes.org/id/BAE78217 EnsemblBacteria BAE78217 http://www.ensemblgenomes.org/id/BAE78217 EnsemblBacteria BAE78217 http://www.ensemblgenomes.org/id/BAE78217 EnsemblBacteria b4216 http://www.ensemblgenomes.org/id/b4216 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GeneID 948737 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948737 HOGENOM HOG000282789 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000282789&db=HOGENOM6 InterPro IPR006513 http://www.ebi.ac.uk/interpro/entry/IPR006513 KEGG_Gene ecj:JW4175 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4175 KEGG_Gene eco:b4216 http://www.genome.jp/dbget-bin/www_bget?eco:b4216 KEGG_Orthology KO:K07109 http://www.genome.jp/dbget-bin/www_bget?KO:K07109 OMA QFSYKNW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QFSYKNW PSORT swissprot:YTFJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YTFJ_ECOLI PSORT-B swissprot:YTFJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YTFJ_ECOLI PSORT2 swissprot:YTFJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YTFJ_ECOLI Pfam PF09695 http://pfam.xfam.org/family/PF09695 Phobius swissprot:YTFJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YTFJ_ECOLI ProteinModelPortal P39187 http://www.proteinmodelportal.org/query/uniprot/P39187 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 7764507 http://www.ncbi.nlm.nih.gov/pubmed/7764507 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_418637 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418637 RefSeq WP_000175279 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000175279 SMR P39187 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39187 STRING 511145.b4216 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4216&targetmode=cogs STRING COG3054 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3054&targetmode=cogs TIGRFAMs TIGR01626 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01626 UniProtKB YTFJ_ECOLI http://www.uniprot.org/uniprot/YTFJ_ECOLI UniProtKB-AC P39187 http://www.uniprot.org/uniprot/P39187 charge swissprot:YTFJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YTFJ_ECOLI eggNOG COG3054 http://eggnogapi.embl.de/nog_data/html/tree/COG3054 eggNOG ENOG4108UUE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UUE epestfind swissprot:YTFJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YTFJ_ECOLI garnier swissprot:YTFJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YTFJ_ECOLI helixturnhelix swissprot:YTFJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YTFJ_ECOLI hmoment swissprot:YTFJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YTFJ_ECOLI iep swissprot:YTFJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YTFJ_ECOLI inforesidue swissprot:YTFJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YTFJ_ECOLI octanol swissprot:YTFJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YTFJ_ECOLI pepcoil swissprot:YTFJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YTFJ_ECOLI pepdigest swissprot:YTFJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YTFJ_ECOLI pepinfo swissprot:YTFJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YTFJ_ECOLI pepnet swissprot:YTFJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YTFJ_ECOLI pepstats swissprot:YTFJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YTFJ_ECOLI pepwheel swissprot:YTFJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YTFJ_ECOLI pepwindow swissprot:YTFJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YTFJ_ECOLI sigcleave swissprot:YTFJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YTFJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4260188 15 # CDD cd07377 WHTH_GntR # EcoGene EG13761 ydcR # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_function GO:0008483 transaminase activity; IEA:UniProtKB-KW. # GO_function GO:0030170 pyridoxal phosphate binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; ISS:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # Gene3D 3.40.640.10 -; 1. # IntAct P77730 3 # InterPro IPR000524 Tscrpt_reg_HTH_GntR # InterPro IPR004839 Aminotransferase_I/II # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR015421 PyrdxlP-dep_Trfase_major_sub1 # InterPro IPR015424 PyrdxlP-dep_Trfase # Organism YDCR_ECOLI Escherichia coli (strain K12) # PATRIC 32118168 VBIEscCol129921_1504 # PIR B64896 B64896 # PROSITE PS50949 HTH_GNTR # Pfam PF00155 Aminotran_1_2 # Pfam PF00392 GntR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDCR_ECOLI Uncharacterized HTH-type transcriptional regulator YdcR # RefSeq NP_415956 NC_000913.3 # RefSeq WP_000760626 NZ_LN832404.1 # SIMILARITY Contains 1 HTH gntR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00307}. # SIMILARITY In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. {ECO 0000305}. # SMART SM00345 HTH_GNTR # SUPFAM SSF46785 SSF46785 # SUPFAM SSF53383 SSF53383 # eggNOG COG1167 LUCA # eggNOG ENOG4105C1I Bacteria BLAST swissprot:YDCR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDCR_ECOLI BioCyc ECOL316407:JW1434-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1434-MONOMER BioCyc EcoCyc:G6750-MONOMER http://biocyc.org/getid?id=EcoCyc:G6750-MONOMER DIP DIP-28077N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-28077N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3524 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3524 EcoGene EG13761 http://www.ecogene.org/geneInfo.php?eg_id=EG13761 EnsemblBacteria AAC74521 http://www.ensemblgenomes.org/id/AAC74521 EnsemblBacteria AAC74521 http://www.ensemblgenomes.org/id/AAC74521 EnsemblBacteria BAA15069 http://www.ensemblgenomes.org/id/BAA15069 EnsemblBacteria BAA15069 http://www.ensemblgenomes.org/id/BAA15069 EnsemblBacteria BAA15069 http://www.ensemblgenomes.org/id/BAA15069 EnsemblBacteria b1439 http://www.ensemblgenomes.org/id/b1439 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0008483 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008483 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 3.40.640.10 http://www.cathdb.info/version/latest/superfamily/3.40.640.10 GeneID 946004 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946004 HOGENOM HOG000133006 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000133006&db=HOGENOM6 InParanoid P77730 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77730 IntAct P77730 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77730* InterPro IPR000524 http://www.ebi.ac.uk/interpro/entry/IPR000524 InterPro IPR004839 http://www.ebi.ac.uk/interpro/entry/IPR004839 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR015421 http://www.ebi.ac.uk/interpro/entry/IPR015421 InterPro IPR015424 http://www.ebi.ac.uk/interpro/entry/IPR015424 KEGG_Gene ecj:JW1434 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1434 KEGG_Gene eco:b1439 http://www.genome.jp/dbget-bin/www_bget?eco:b1439 OMA YFRFNTA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YFRFNTA PROSITE PS50949 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50949 PSORT swissprot:YDCR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDCR_ECOLI PSORT-B swissprot:YDCR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDCR_ECOLI PSORT2 swissprot:YDCR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDCR_ECOLI Pfam PF00155 http://pfam.xfam.org/family/PF00155 Pfam PF00392 http://pfam.xfam.org/family/PF00392 Phobius swissprot:YDCR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDCR_ECOLI PhylomeDB P77730 http://phylomedb.org/?seqid=P77730 ProteinModelPortal P77730 http://www.proteinmodelportal.org/query/uniprot/P77730 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415956 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415956 RefSeq WP_000760626 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000760626 SMART SM00345 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00345 SMR P77730 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77730 STRING 511145.b1439 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1439&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SUPFAM SSF53383 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53383 UniProtKB YDCR_ECOLI http://www.uniprot.org/uniprot/YDCR_ECOLI UniProtKB-AC P77730 http://www.uniprot.org/uniprot/P77730 charge swissprot:YDCR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDCR_ECOLI eggNOG COG1167 http://eggnogapi.embl.de/nog_data/html/tree/COG1167 eggNOG ENOG4105C1I http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C1I epestfind swissprot:YDCR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDCR_ECOLI garnier swissprot:YDCR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDCR_ECOLI helixturnhelix swissprot:YDCR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDCR_ECOLI hmoment swissprot:YDCR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDCR_ECOLI iep swissprot:YDCR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDCR_ECOLI inforesidue swissprot:YDCR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDCR_ECOLI octanol swissprot:YDCR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDCR_ECOLI pepcoil swissprot:YDCR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDCR_ECOLI pepdigest swissprot:YDCR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDCR_ECOLI pepinfo swissprot:YDCR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDCR_ECOLI pepnet swissprot:YDCR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDCR_ECOLI pepstats swissprot:YDCR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDCR_ECOLI pepwheel swissprot:YDCR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDCR_ECOLI pepwindow swissprot:YDCR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDCR_ECOLI sigcleave swissprot:YDCR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDCR_ECOLI ## Database ID URL or Descriptions # AltName 2,3-dihydro-2,3-dihydroxybenzoate synthase {ECO:0000303|PubMed 2139796} # AltName Enterobactin biosynthesis bifunctional protein EntB {ECO:0000303|PubMed 9214294} # AltName Enterochelin synthase B {ECO:0000303|PubMed 2531000} # AltName Enterochelin synthase B {ECO:0000303|PubMed 2531000} # AltName Isochorismate lyase {ECO:0000303|PubMed 2139796} # AltName Isochorismate lyase {ECO:0000303|PubMed 2139796} # BIOPHYSICOCHEMICAL PROPERTIES ENTB_ECOLI Kinetic parameters KM=14.7 uM for isochorismate (at pH 7 and 37 degrees Celsius) {ECO 0000269|PubMed 2139796}; KM=23 uM for 4,5-dihydroisochorismate (at pH 7 and 37 degrees Celsius) {ECO 0000269|PubMed 2139796}; KM=86 uM for 3-[(carboxyethenyl)oxy]-1-cyclohexene-1-carboxylic acid (at pH 7 and 37 degrees Celsius) {ECO 0000269|PubMed 2139796}; KM=120 uM for 3-[(1-carboxylatoethenyl)oxy]-cyclohepta-1,6- diene-1-carboxylate (at pH 7 and 37 degrees Celsius) {ECO 0000269|PubMed 2139796}; KM=280 uM for cis-3-[(carboxyethenyl)oxy]-4-cyclohexene-1- carboxylic acid (at pH 7 and 37 degrees Celsius) {ECO 0000269|PubMed 2139796}; Vmax=18.5 umol/min/mg enzyme (at pH 7 and 37 degrees Celsius) {ECO 0000269|PubMed 2139796}; Note=Kcat is 600 min(-1) for isochorismatase activity with isochorismate as substrate (at pH 7 and 37 degrees Celsius). Kcat is 540 min(-1) for isochorismatase activity with 3-[(1- carboxylatoethenyl)oxy]-cyclohepta-1,6-diene-1-carboxylate as substrate (at pH 7 and 37 degrees Celsius). Kcat is 310 min(-1) for isochorismatase activity with 4,5-dihydroisochorismate as substrate (at pH 7 and 37 degrees Celsius). {ECO 0000269|PubMed 2139796}; pH dependence Optimum pH is between 6.5 and 7.5. At pH 5.5, EntB retains 50% of isochorismatase activity. {ECO 0000269|PubMed 2139796}; # BRENDA 3.3.2 2026 # BRENDA 6.3.2.14 2026 # BioGrid 4260905 198 # CATALYTIC ACTIVITY ENTB_ECOLI 6 ATP + 3 2,3-dihydroxybenzoate + 3 L-serine = enterobactin + 6 AMP + 6 diphosphate. {ECO 0000269|PubMed 16632253, ECO 0000269|PubMed 2139796, ECO 0000269|PubMed 9214294, ECO 0000269|PubMed 9485415}. # CATALYTIC ACTIVITY ENTB_ECOLI Isochorismate + H(2)O = (2S,3S)-2,3-dihydroxy- 2,3-dihydrobenzoate + pyruvate. {ECO 0000269|PubMed 16632253, ECO 0000269|PubMed 2139796, ECO 0000269|PubMed 9214294, ECO 0000269|PubMed 9485415}. # COFACTOR ENTB_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 16632253}; # DISRUPTION PHENOTYPE Cells lacking this gene are hypersensitive to the antimicrobial peptide wrwycr. {ECO:0000269|PubMed 22096151}. # ENZYME REGULATION Inhibited by 3-[(carboxyethenyl)oxy]-6-hydroxy- 1-benzoic acid and 3-[(carboxyethenyl)oxy]benzoic acid. {ECO:0000269|PubMed 2139796}. # EcoGene EG10260 entB # FUNCTION ENTB_ECOLI Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3-dihydroxybenzoyl)-serine. The serine trilactone serves as a scaffolding for the three catechol functionalities that provide hexadentate coordination for the tightly ligated iron(2+) atoms. EntB is a bifunctional protein that serves as an isochorismate lyase and an aryl carrier protein (ArCP). Catalyzes the conversion of isochorismate to 2,3-dihydro-2,3- dihydroxybenzoate (2,3-diDHB), the precursor of 2,3- dihydroxybenzoate (DHB). In the enterobactin assembly, EntB functions as an aryl carrier protein phosphopantetheinylated near the C terminus by EntD to yield holo-EntB, which is then acylated by EntE with 2,3-dihydroxybenzoyl-AMP to form DHB-holo-EntB. Then this product will serve in the formation of the amide bond between 2,3-dihydroxybenzoate (DHB) and L-serine. {ECO 0000269|PubMed 16567620, ECO 0000269|PubMed 16632253, ECO 0000269|PubMed 19699210, ECO 0000269|PubMed 2139796, ECO 0000269|PubMed 2172214, ECO 0000269|PubMed 2531000, ECO 0000269|PubMed 9214294, ECO 0000269|PubMed 9485415}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IDA:UniProtKB. # GO_function GO:0008908 isochorismatase activity; IDA:UniProtKB. # GO_function GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups; IMP:EcoliWiki. # GO_function GO:0031177 phosphopantetheine binding; IDA:UniProtKB. # GO_function GO:0047527 2,3-dihydroxybenzoate-serine ligase activity; IDA:UniProtKB. # GO_process GO:0002047 phenazine biosynthetic process; IBA:GO_Central. # GO_process GO:0009239 enterobactin biosynthetic process; IDA:UniProtKB. # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0019748 secondary metabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 1.10.1200.10 -; 1. # Gene3D 3.40.50.850 -; 1. # INDUCTION Under conditions of iron deficiency and by the fur protein. {ECO:0000269|PubMed 2521621}. # INTERACTION ENTB_ECOLI Self; NbExp=3; IntAct=EBI-547993, EBI-547993; P0A8Y8 entH; NbExp=3; IntAct=EBI-547993, EBI-1118982; # IntAct P0ADI4 29 # InterPro IPR000868 Isochorismatase-like # InterPro IPR009081 PP-bd_ACP # InterPro IPR016291 Isochorismatase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01008 Polyketide biosynthesis proteins # KEGG_Pathway ko01053 Biosynthesis of siderophore group nonribosomal peptides # Organism ENTB_ECOLI Escherichia coli (strain K12) # PATHWAY Siderophore biosynthesis; enterobactin biosynthesis. {ECO:0000305|PubMed 9214294}. # PATRIC 32116366 VBIEscCol129921_0623 # PDB 2FQ1 X-ray; 2.30 A; A/B=1-285 # PDB 3RG2 X-ray; 3.10 A; A/B/C/D/E/F/G/H/I/J=209-285 # PIR C91904 YXECIC # PIRSF PIRSF001111 Isochorismatase # PRINTS PR01398 ISCHRISMTASE # PROSITE PS50075 ACP_DOMAIN # PTM ENTB_ECOLI 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-EntB by EntD. Holo-EntB so formed is then acylated with 2,3-dihydroxybenzoate in a reaction catalyzed by EntE. {ECO 0000269|PubMed 22365602}. # Pfam PF00550 PP-binding # Pfam PF00857 Isochorismatase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Aryl carrier protein {ECO:0000303|PubMed 9214294} # RecName Enterobactin synthase component B {ECO:0000303|PubMed 2531000} # RecName Isochorismatase {ECO:0000303|PubMed 2139796} # RefSeq NP_415127 NC_000913.3 # RefSeq WP_001007138 NZ_LN832404.1 # SIMILARITY Contains 1 acyl carrier domain. {ECO:0000255|PROSITE- ProRule PRU00258}. # SIMILARITY In the N-terminal section; belongs to the isochorismatase family. {ECO 0000305}. # SUBCELLULAR LOCATION ENTB_ECOLI Cytoplasm {ECO 0000269|PubMed 10692387}. # SUBUNIT ENTB_ECOLI Proteins EntB, EntD, EntE, and EntF form a multienzyme complex called enterobactin synthase. Dimer. {ECO 0000269|PubMed 16632253, ECO 0000269|PubMed 2139796, ECO 0000269|PubMed 22365602, ECO 0000269|PubMed 9485415}. # SUPFAM SSF47336 SSF47336 # SUPFAM SSF52499 SSF52499 # eggNOG COG1535 LUCA # eggNOG COG3433 LUCA # eggNOG ENOG4105WQI Bacteria BLAST swissprot:ENTB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ENTB_ECOLI BioCyc ECOL316407:JW0587-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0587-MONOMER BioCyc EcoCyc:ENTB-MONOMER http://biocyc.org/getid?id=EcoCyc:ENTB-MONOMER BioCyc MetaCyc:ENTB-MONOMER http://biocyc.org/getid?id=MetaCyc:ENTB-MONOMER COG COG1535 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1535 COG COG3433 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3433 DIP DIP-9512N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9512N DOI 10.1016/j.chembiol.2006.02.005 http://dx.doi.org/10.1016/j.chembiol.2006.02.005 DOI 10.1016/j.chembiol.2011.11.013 http://dx.doi.org/10.1016/j.chembiol.2011.11.013 DOI 10.1016/j.jmb.2009.08.036 http://dx.doi.org/10.1016/j.jmb.2009.08.036 DOI 10.1021/bi00443a008 http://dx.doi.org/10.1021/bi00443a008 DOI 10.1021/bi00458a013 http://dx.doi.org/10.1021/bi00458a013 DOI 10.1021/bi970453p http://dx.doi.org/10.1021/bi970453p DOI 10.1021/bi9726584 http://dx.doi.org/10.1021/bi9726584 DOI 10.1021/ja063238h http://dx.doi.org/10.1021/ja063238h DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0601038103 http://dx.doi.org/10.1073/pnas.0601038103 DOI 10.1099/mic.0.054361-0 http://dx.doi.org/10.1099/mic.0.054361-0 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.6.1768-1773.2000 http://dx.doi.org/10.1128/JB.182.6.1768-1773.2000 EC_number EC:3.3.2.1 {ECO:0000269|PubMed:16632253, ECO:0000269|PubMed:2139796, ECO:0000269|PubMed:9214294, ECO:0000269|PubMed:9485415} http://www.genome.jp/dbget-bin/www_bget?EC:3.3.2.1 {ECO:0000269|PubMed:16632253, ECO:0000269|PubMed:2139796, ECO:0000269|PubMed:9214294, ECO:0000269|PubMed:9485415} EC_number EC:6.3.2.14 {ECO:0000269|PubMed:16632253, ECO:0000269|PubMed:2139796, ECO:0000269|PubMed:9214294, ECO:0000269|PubMed:9485415} http://www.genome.jp/dbget-bin/www_bget?EC:6.3.2.14 {ECO:0000269|PubMed:16632253, ECO:0000269|PubMed:2139796, ECO:0000269|PubMed:9214294, ECO:0000269|PubMed:9485415} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M24143 http://www.ebi.ac.uk/ena/data/view/M24143 EMBL M24148 http://www.ebi.ac.uk/ena/data/view/M24148 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 ENZYME 3.3.2.1 {ECO:0000269|PubMed:16632253, ECO:0000269|PubMed:2139796, ECO:0000269|PubMed:9214294, ECO:0000269|PubMed:9485415} http://enzyme.expasy.org/EC/3.3.2.1 {ECO:0000269|PubMed:16632253, ECO:0000269|PubMed:2139796, ECO:0000269|PubMed:9214294, ECO:0000269|PubMed:9485415} ENZYME 6.3.2.14 {ECO:0000269|PubMed:16632253, ECO:0000269|PubMed:2139796, ECO:0000269|PubMed:9214294, ECO:0000269|PubMed:9485415} http://enzyme.expasy.org/EC/6.3.2.14 {ECO:0000269|PubMed:16632253, ECO:0000269|PubMed:2139796, ECO:0000269|PubMed:9214294, ECO:0000269|PubMed:9485415} EchoBASE EB0256 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0256 EcoGene EG10260 http://www.ecogene.org/geneInfo.php?eg_id=EG10260 EnsemblBacteria AAC73696 http://www.ensemblgenomes.org/id/AAC73696 EnsemblBacteria AAC73696 http://www.ensemblgenomes.org/id/AAC73696 EnsemblBacteria BAE76350 http://www.ensemblgenomes.org/id/BAE76350 EnsemblBacteria BAE76350 http://www.ensemblgenomes.org/id/BAE76350 EnsemblBacteria BAE76350 http://www.ensemblgenomes.org/id/BAE76350 EnsemblBacteria b0595 http://www.ensemblgenomes.org/id/b0595 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0008908 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008908 GO_function GO:0016765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016765 GO_function GO:0031177 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031177 GO_function GO:0047527 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047527 GO_process GO:0002047 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002047 GO_process GO:0009239 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009239 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016765 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0019748 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019748 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 1.10.1200.10 http://www.cathdb.info/version/latest/superfamily/1.10.1200.10 Gene3D 3.40.50.850 http://www.cathdb.info/version/latest/superfamily/3.40.50.850 GeneID 946178 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946178 HOGENOM HOG000078667 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000078667&db=HOGENOM6 InParanoid P0ADI4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADI4 IntAct P0ADI4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADI4* IntEnz 3.3.2.1 {ECO:0000269|PubMed:16632253, ECO:0000269|PubMed:2139796, ECO:0000269|PubMed:9214294, ECO:0000269|PubMed:9485415} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.3.2.1 {ECO:0000269|PubMed:16632253, ECO:0000269|PubMed:2139796, ECO:0000269|PubMed:9214294, ECO:0000269|PubMed:9485415} IntEnz 6.3.2.14 {ECO:0000269|PubMed:16632253, ECO:0000269|PubMed:2139796, ECO:0000269|PubMed:9214294, ECO:0000269|PubMed:9485415} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.2.14 {ECO:0000269|PubMed:16632253, ECO:0000269|PubMed:2139796, ECO:0000269|PubMed:9214294, ECO:0000269|PubMed:9485415} InterPro IPR000868 http://www.ebi.ac.uk/interpro/entry/IPR000868 InterPro IPR009081 http://www.ebi.ac.uk/interpro/entry/IPR009081 InterPro IPR016291 http://www.ebi.ac.uk/interpro/entry/IPR016291 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01008 http://www.genome.jp/dbget-bin/www_bget?ko01008 KEGG_Gene ecj:JW0587 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0587 KEGG_Gene eco:b0595 http://www.genome.jp/dbget-bin/www_bget?eco:b0595 KEGG_Orthology KO:K01252 http://www.genome.jp/dbget-bin/www_bget?KO:K01252 KEGG_Pathway ko01053 http://www.genome.jp/kegg-bin/show_pathway?ko01053 KEGG_Reaction rn:R03037 http://www.genome.jp/dbget-bin/www_bget?rn:R03037 MINT MINT-1241343 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1241343 OMA RDIKPFF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RDIKPFF PDB 2FQ1 http://www.ebi.ac.uk/pdbe-srv/view/entry/2FQ1 PDB 3RG2 http://www.ebi.ac.uk/pdbe-srv/view/entry/3RG2 PDBsum 2FQ1 http://www.ebi.ac.uk/pdbsum/2FQ1 PDBsum 3RG2 http://www.ebi.ac.uk/pdbsum/3RG2 PRINTS PR01398 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01398 PROSITE PS50075 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50075 PSORT swissprot:ENTB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ENTB_ECOLI PSORT-B swissprot:ENTB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ENTB_ECOLI PSORT2 swissprot:ENTB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ENTB_ECOLI Pfam PF00550 http://pfam.xfam.org/family/PF00550 Pfam PF00857 http://pfam.xfam.org/family/PF00857 Phobius swissprot:ENTB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ENTB_ECOLI PhylomeDB P0ADI4 http://phylomedb.org/?seqid=P0ADI4 ProteinModelPortal P0ADI4 http://www.proteinmodelportal.org/query/uniprot/P0ADI4 PubMed 10692387 http://www.ncbi.nlm.nih.gov/pubmed/10692387 PubMed 16567620 http://www.ncbi.nlm.nih.gov/pubmed/16567620 PubMed 16632253 http://www.ncbi.nlm.nih.gov/pubmed/16632253 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16925399 http://www.ncbi.nlm.nih.gov/pubmed/16925399 PubMed 19699210 http://www.ncbi.nlm.nih.gov/pubmed/19699210 PubMed 2139796 http://www.ncbi.nlm.nih.gov/pubmed/2139796 PubMed 2172214 http://www.ncbi.nlm.nih.gov/pubmed/2172214 PubMed 22096151 http://www.ncbi.nlm.nih.gov/pubmed/22096151 PubMed 22365602 http://www.ncbi.nlm.nih.gov/pubmed/22365602 PubMed 2521621 http://www.ncbi.nlm.nih.gov/pubmed/2521621 PubMed 2521622 http://www.ncbi.nlm.nih.gov/pubmed/2521622 PubMed 2531000 http://www.ncbi.nlm.nih.gov/pubmed/2531000 PubMed 9214294 http://www.ncbi.nlm.nih.gov/pubmed/9214294 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9485415 http://www.ncbi.nlm.nih.gov/pubmed/9485415 RefSeq NP_415127 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415127 RefSeq WP_001007138 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001007138 SMR P0ADI4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADI4 STRING 511145.b0595 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0595&targetmode=cogs STRING COG1535 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1535&targetmode=cogs STRING COG3433 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3433&targetmode=cogs SUPFAM SSF47336 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47336 SUPFAM SSF52499 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52499 SWISS-2DPAGE P0ADI4 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0ADI4 UniProtKB ENTB_ECOLI http://www.uniprot.org/uniprot/ENTB_ECOLI UniProtKB-AC P0ADI4 http://www.uniprot.org/uniprot/P0ADI4 charge swissprot:ENTB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ENTB_ECOLI eggNOG COG1535 http://eggnogapi.embl.de/nog_data/html/tree/COG1535 eggNOG COG3433 http://eggnogapi.embl.de/nog_data/html/tree/COG3433 eggNOG ENOG4105WQI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105WQI epestfind swissprot:ENTB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ENTB_ECOLI garnier swissprot:ENTB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ENTB_ECOLI helixturnhelix swissprot:ENTB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ENTB_ECOLI hmoment swissprot:ENTB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ENTB_ECOLI iep swissprot:ENTB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ENTB_ECOLI inforesidue swissprot:ENTB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ENTB_ECOLI octanol swissprot:ENTB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ENTB_ECOLI pepcoil swissprot:ENTB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ENTB_ECOLI pepdigest swissprot:ENTB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ENTB_ECOLI pepinfo swissprot:ENTB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ENTB_ECOLI pepnet swissprot:ENTB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ENTB_ECOLI pepstats swissprot:ENTB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ENTB_ECOLI pepwheel swissprot:ENTB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ENTB_ECOLI pepwindow swissprot:ENTB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ENTB_ECOLI sigcleave swissprot:ENTB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ENTB_ECOLI ## Database ID URL or Descriptions # AltName MURC_ECOLI UDP-N-acetylmuramoyl-L-alanine synthetase # BIOPHYSICOCHEMICAL PROPERTIES MURC_ECOLI Kinetic parameters KM=100 uM for UDP-N-acetyl-alpha-D-muramate {ECO 0000269|PubMed 7601127}; KM=20 uM for L-alanine {ECO 0000269|PubMed 7601127}; KM=450 uM for ATP {ECO 0000269|PubMed 7601127}; Vmax=17.3 umol/min/mg enzyme {ECO 0000269|PubMed 7601127}; pH dependence Optimum pH is 8.6. {ECO 0000269|PubMed 7601127}; Temperature dependence Optimum temperature is 45 degrees Celsius. {ECO 0000269|PubMed 7601127}; # BRENDA 6.3.2 2026 # BioGrid 4261857 473 # CATALYTIC ACTIVITY ATP + UDP-N-acetyl-alpha-D-muramate + L- alanine = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L- alanine. {ECO:0000269|PubMed 7601127}. # EcoGene EG10619 murC # FUNCTION MURC_ECOLI Cell wall formation. {ECO 0000269|PubMed 7601127}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0000287 magnesium ion binding; IDA:EcoliWiki. # GO_function GO:0005524 ATP binding; IDA:EcoliWiki. # GO_function GO:0008763 UDP-N-acetylmuramate-L-alanine ligase activity; IDA:EcoliWiki. # GO_process GO:0007049 cell cycle; IEA:UniProtKB-KW. # GO_process GO:0008360 regulation of cell shape; IEA:UniProtKB-KW. # GO_process GO:0009252 peptidoglycan biosynthetic process; IMP:EcoCyc. # GO_process GO:0051301 cell division; IEA:UniProtKB-KW. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0007049 cell cycle # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0051301 cell division # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 3.40.1190.10 -; 1. # Gene3D 3.40.50.720 -; 1. # Gene3D 3.90.190.20 -; 1. # HAMAP MF_00046 MurC # INTERACTION MURC_ECOLI P77609 flxA; NbExp=3; IntAct=EBI-554607, EBI-553024; # IntAct P17952 15 # InterPro IPR000713 Mur_ligase_N # InterPro IPR004101 Mur_ligase_C # InterPro IPR005758 UDP-N-AcMur_Ala_ligase_murC # InterPro IPR013221 Mur_ligase_cen # InterPro IPR016040 NAD(P)-bd_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00471 D-Glutamine and D-glutamate metabolism # KEGG_Pathway ko00550 Peptidoglycan biosynthesis # Organism MURC_ECOLI Escherichia coli (strain K12) # PATHWAY MURC_ECOLI Cell wall biogenesis; peptidoglycan biosynthesis. # PATRIC 32115287 VBIEscCol129921_0095 # PDB 1CC9 Model; -; A=1-491 # PDB 2F00 X-ray; 2.50 A; A/B=1-491 # PIR JQ0545 CEECAM # Pfam PF01225 Mur_ligase # Pfam PF02875 Mur_ligase_C # Pfam PF08245 Mur_ligase_M # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MURC_ECOLI UDP-N-acetylmuramate--L-alanine ligase # RefSeq NP_414633 NC_000913.3 # RefSeq WP_001096049 NZ_LN832404.1 # SIMILARITY Belongs to the MurCDEF family. {ECO 0000305}. # SUBCELLULAR LOCATION MURC_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF53244 SSF53244 # SUPFAM SSF53623 SSF53623 # TIGRFAMs TIGR01082 murC # eggNOG COG0773 LUCA # eggNOG ENOG4105DFU Bacteria BLAST swissprot:MURC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MURC_ECOLI BioCyc ECOL316407:JW0089-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0089-MONOMER BioCyc EcoCyc:UDP-NACMUR-ALA-LIG-MONOMER http://biocyc.org/getid?id=EcoCyc:UDP-NACMUR-ALA-LIG-MONOMER BioCyc MetaCyc:UDP-NACMUR-ALA-LIG-MONOMER http://biocyc.org/getid?id=MetaCyc:UDP-NACMUR-ALA-LIG-MONOMER COG COG0773 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0773 DIP DIP-10278N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10278N DOI 10.1021/bi9701078 http://dx.doi.org/10.1021/bi9701078 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/18.13.4014 http://dx.doi.org/10.1093/nar/18.13.4014 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1111/j.1432-1033.1995.0080i.x http://dx.doi.org/10.1111/j.1432-1033.1995.0080i.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.3.2.8 http://www.genome.jp/dbget-bin/www_bget?EC:6.3.2.8 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U67892 http://www.ebi.ac.uk/ena/data/view/U67892 EMBL X52644 http://www.ebi.ac.uk/ena/data/view/X52644 EMBL X55034 http://www.ebi.ac.uk/ena/data/view/X55034 ENZYME 6.3.2.8 http://enzyme.expasy.org/EC/6.3.2.8 EchoBASE EB0614 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0614 EcoGene EG10619 http://www.ecogene.org/geneInfo.php?eg_id=EG10619 EnsemblBacteria AAC73202 http://www.ensemblgenomes.org/id/AAC73202 EnsemblBacteria AAC73202 http://www.ensemblgenomes.org/id/AAC73202 EnsemblBacteria BAB96659 http://www.ensemblgenomes.org/id/BAB96659 EnsemblBacteria BAB96659 http://www.ensemblgenomes.org/id/BAB96659 EnsemblBacteria BAB96659 http://www.ensemblgenomes.org/id/BAB96659 EnsemblBacteria b0091 http://www.ensemblgenomes.org/id/b0091 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008763 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008763 GO_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0009252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009252 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 3.40.1190.10 http://www.cathdb.info/version/latest/superfamily/3.40.1190.10 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 Gene3D 3.90.190.20 http://www.cathdb.info/version/latest/superfamily/3.90.190.20 GeneID 946153 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946153 HAMAP MF_00046 http://hamap.expasy.org/unirule/MF_00046 HOGENOM HOG000256031 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000256031&db=HOGENOM6 InParanoid P17952 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P17952 IntAct P17952 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P17952* IntEnz 6.3.2.8 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.2.8 InterPro IPR000713 http://www.ebi.ac.uk/interpro/entry/IPR000713 InterPro IPR004101 http://www.ebi.ac.uk/interpro/entry/IPR004101 InterPro IPR005758 http://www.ebi.ac.uk/interpro/entry/IPR005758 InterPro IPR013221 http://www.ebi.ac.uk/interpro/entry/IPR013221 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0089 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0089 KEGG_Gene eco:b0091 http://www.genome.jp/dbget-bin/www_bget?eco:b0091 KEGG_Orthology KO:K01924 http://www.genome.jp/dbget-bin/www_bget?KO:K01924 KEGG_Pathway ko00471 http://www.genome.jp/kegg-bin/show_pathway?ko00471 KEGG_Pathway ko00550 http://www.genome.jp/kegg-bin/show_pathway?ko00550 KEGG_Reaction rn:R03193 http://www.genome.jp/dbget-bin/www_bget?rn:R03193 MINT MINT-1222662 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1222662 OMA FHFIGIG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FHFIGIG PDB 1CC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1CC9 PDB 2F00 http://www.ebi.ac.uk/pdbe-srv/view/entry/2F00 PDBsum 1CC9 http://www.ebi.ac.uk/pdbsum/1CC9 PDBsum 2F00 http://www.ebi.ac.uk/pdbsum/2F00 PSORT swissprot:MURC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MURC_ECOLI PSORT-B swissprot:MURC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MURC_ECOLI PSORT2 swissprot:MURC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MURC_ECOLI Pfam PF01225 http://pfam.xfam.org/family/PF01225 Pfam PF02875 http://pfam.xfam.org/family/PF02875 Pfam PF08245 http://pfam.xfam.org/family/PF08245 Phobius swissprot:MURC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MURC_ECOLI PhylomeDB P17952 http://phylomedb.org/?seqid=P17952 ProteinModelPortal P17952 http://www.proteinmodelportal.org/query/uniprot/P17952 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2197603 http://www.ncbi.nlm.nih.gov/pubmed/2197603 PubMed 7601127 http://www.ncbi.nlm.nih.gov/pubmed/7601127 PubMed 9166795 http://www.ncbi.nlm.nih.gov/pubmed/9166795 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414633 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414633 RefSeq WP_001096049 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001096049 SMR P17952 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P17952 STRING 511145.b0091 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0091&targetmode=cogs STRING COG0773 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0773&targetmode=cogs SUPFAM SSF53244 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53244 SUPFAM SSF53623 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53623 TIGRFAMs TIGR01082 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01082 UniProtKB MURC_ECOLI http://www.uniprot.org/uniprot/MURC_ECOLI UniProtKB-AC P17952 http://www.uniprot.org/uniprot/P17952 charge swissprot:MURC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MURC_ECOLI eggNOG COG0773 http://eggnogapi.embl.de/nog_data/html/tree/COG0773 eggNOG ENOG4105DFU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DFU epestfind swissprot:MURC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MURC_ECOLI garnier swissprot:MURC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MURC_ECOLI helixturnhelix swissprot:MURC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MURC_ECOLI hmoment swissprot:MURC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MURC_ECOLI iep swissprot:MURC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MURC_ECOLI inforesidue swissprot:MURC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MURC_ECOLI octanol swissprot:MURC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MURC_ECOLI pepcoil swissprot:MURC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MURC_ECOLI pepdigest swissprot:MURC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MURC_ECOLI pepinfo swissprot:MURC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MURC_ECOLI pepnet swissprot:MURC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MURC_ECOLI pepstats swissprot:MURC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MURC_ECOLI pepwheel swissprot:MURC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MURC_ECOLI pepwindow swissprot:MURC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MURC_ECOLI sigcleave swissprot:MURC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MURC_ECOLI ## Database ID URL or Descriptions # AltName YHHW_ECOLI Pirin-like protein YhhW # BioGrid 4261175 17 # CATALYTIC ACTIVITY Quercetin + O(2) = 2-(3,4- dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO + H(+). {ECO:0000269|PubMed 15951572}. # COFACTOR YHHW_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 15951572}; Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000269|PubMed 15951572}; Name=Fe(2+); Xref=ChEBI CHEBI 29033; Evidence={ECO 0000269|PubMed 15951572}; Note=Binds 1 divalent metal cation, Zn(2+), Co(2+) or Fe(2+). {ECO 0000269|PubMed 15951572}; # DOMAIN YHHW_ECOLI Is composed of two structurally similar domains arranged face to face. {ECO 0000269|PubMed 15951572}. # ENZYME REGULATION Inhibited by kojic acid, sodium diethyldithiocarbamate and 1,10-phenanthroline monohydrochloride. {ECO:0000269|PubMed 15951572}. # EcoGene EG12943 yhhW # FUNCTION YHHW_ECOLI Has quercetin 2,3-dioxygenase activity in vitro. Its physiological role is unknown; however, may provide a mechanism that would avoid inhibition of key cellular proteins, such as DNA gyrase, by quercetin. {ECO 0000269|PubMed 15951572}. # GO_function GO:0008127 quercetin 2,3-dioxygenase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # Gene3D 2.60.120.10 -; 1. # IntAct P46852 9 # InterPro IPR003829 Pirin_N_dom # InterPro IPR011051 RmlC_Cupin # InterPro IPR012093 Pirin # InterPro IPR014710 RmlC-like_jellyroll # MISCELLANEOUS YHHW_ECOLI Quercetin is a flavonoid compound synthesized by a variety of plants, including foods for human consumption. # Organism YHHW_ECOLI Escherichia coli (strain K12) # PANTHER PTHR13903 PTHR13903 # PATHWAY YHHW_ECOLI Flavonoid metabolism; quercetin degradation. # PATRIC 32122318 VBIEscCol129921_3536 # PDB 1TQ5 X-ray; 1.76 A; A=1-231 # PIR B65140 B65140 # PIRSF PIRSF006232 Pirin # Pfam PF02678 Pirin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHHW_ECOLI Quercetin 2,3-dioxygenase # RefSeq NP_417896 NC_000913.3 # RefSeq WP_000639811 NZ_LN832404.1 # SIMILARITY Belongs to the pirin family. {ECO 0000305}. # SUPFAM SSF51182 SSF51182 # eggNOG COG1741 LUCA # eggNOG ENOG4105C2I Bacteria BLAST swissprot:YHHW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHHW_ECOLI BioCyc ECOL316407:JW3402-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3402-MONOMER BioCyc EcoCyc:G7756-MONOMER http://biocyc.org/getid?id=EcoCyc:G7756-MONOMER BioCyc MetaCyc:G7756-MONOMER http://biocyc.org/getid?id=MetaCyc:G7756-MONOMER COG COG1741 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1741 DIP DIP-12356N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12356N DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M501034200 http://dx.doi.org/10.1074/jbc.M501034200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.13.11.24 http://www.genome.jp/dbget-bin/www_bget?EC:1.13.11.24 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 1.13.11.24 http://enzyme.expasy.org/EC/1.13.11.24 EchoBASE EB2777 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2777 EcoGene EG12943 http://www.ecogene.org/geneInfo.php?eg_id=EG12943 EnsemblBacteria AAC76464 http://www.ensemblgenomes.org/id/AAC76464 EnsemblBacteria AAC76464 http://www.ensemblgenomes.org/id/AAC76464 EnsemblBacteria BAE77854 http://www.ensemblgenomes.org/id/BAE77854 EnsemblBacteria BAE77854 http://www.ensemblgenomes.org/id/BAE77854 EnsemblBacteria BAE77854 http://www.ensemblgenomes.org/id/BAE77854 EnsemblBacteria b3439 http://www.ensemblgenomes.org/id/b3439 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008127 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008127 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 2.60.120.10 http://www.cathdb.info/version/latest/superfamily/2.60.120.10 GeneID 947945 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947945 HOGENOM HOG000114205 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000114205&db=HOGENOM6 InParanoid P46852 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P46852 IntAct P46852 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P46852* IntEnz 1.13.11.24 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.13.11.24 InterPro IPR003829 http://www.ebi.ac.uk/interpro/entry/IPR003829 InterPro IPR011051 http://www.ebi.ac.uk/interpro/entry/IPR011051 InterPro IPR012093 http://www.ebi.ac.uk/interpro/entry/IPR012093 InterPro IPR014710 http://www.ebi.ac.uk/interpro/entry/IPR014710 KEGG_Gene ecj:JW3402 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3402 KEGG_Gene eco:b3439 http://www.genome.jp/dbget-bin/www_bget?eco:b3439 KEGG_Orthology KO:K06911 http://www.genome.jp/dbget-bin/www_bget?KO:K06911 OMA GFPTHGH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GFPTHGH PANTHER PTHR13903 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13903 PDB 1TQ5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1TQ5 PDBsum 1TQ5 http://www.ebi.ac.uk/pdbsum/1TQ5 PSORT swissprot:YHHW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHHW_ECOLI PSORT-B swissprot:YHHW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHHW_ECOLI PSORT2 swissprot:YHHW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHHW_ECOLI Pfam PF02678 http://pfam.xfam.org/family/PF02678 Phobius swissprot:YHHW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHHW_ECOLI PhylomeDB P46852 http://phylomedb.org/?seqid=P46852 ProteinModelPortal P46852 http://www.proteinmodelportal.org/query/uniprot/P46852 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 15951572 http://www.ncbi.nlm.nih.gov/pubmed/15951572 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417896 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417896 RefSeq WP_000639811 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000639811 SMR P46852 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P46852 STRING 511145.b3439 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3439&targetmode=cogs STRING COG1741 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1741&targetmode=cogs SUPFAM SSF51182 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51182 UniProtKB YHHW_ECOLI http://www.uniprot.org/uniprot/YHHW_ECOLI UniProtKB-AC P46852 http://www.uniprot.org/uniprot/P46852 charge swissprot:YHHW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHHW_ECOLI eggNOG COG1741 http://eggnogapi.embl.de/nog_data/html/tree/COG1741 eggNOG ENOG4105C2I http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C2I epestfind swissprot:YHHW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHHW_ECOLI garnier swissprot:YHHW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHHW_ECOLI helixturnhelix swissprot:YHHW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHHW_ECOLI hmoment swissprot:YHHW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHHW_ECOLI iep swissprot:YHHW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHHW_ECOLI inforesidue swissprot:YHHW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHHW_ECOLI octanol swissprot:YHHW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHHW_ECOLI pepcoil swissprot:YHHW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHHW_ECOLI pepdigest swissprot:YHHW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHHW_ECOLI pepinfo swissprot:YHHW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHHW_ECOLI pepnet swissprot:YHHW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHHW_ECOLI pepstats swissprot:YHHW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHHW_ECOLI pepwheel swissprot:YHHW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHHW_ECOLI pepwindow swissprot:YHHW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHHW_ECOLI sigcleave swissprot:YHHW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHHW_ECOLI ## Database ID URL or Descriptions # BioGrid 4262293 139 # CDD cd06174 MFS # EcoGene EG13174 yqcE # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0055085 transmembrane transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0055085 transmembrane transport # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # Organism YQCE_ECOLI Escherichia coli (strain K12) # PATRIC 32120960 VBIEscCol129921_2872 # PIR C65059 C65059 # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQCE_ECOLI Inner membrane protein YqcE # RefSeq NP_417255 NC_000913.3 # RefSeq WP_001164544 NZ_LN832404.1 # SIMILARITY To E.coli YihN. {ECO 0000305}. # SUBCELLULAR LOCATION YQCE_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF103473 SSF103473 # eggNOG ENOG4108ITV Bacteria # eggNOG ENOG410Y8F9 LUCA BLAST swissprot:YQCE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQCE_ECOLI BioCyc ECOL316407:JW2746-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2746-MONOMER BioCyc EcoCyc:B2775-MONOMER http://biocyc.org/getid?id=EcoCyc:B2775-MONOMER DIP DIP-12849N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12849N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2966 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2966 EcoGene EG13174 http://www.ecogene.org/geneInfo.php?eg_id=EG13174 EnsemblBacteria AAC75817 http://www.ensemblgenomes.org/id/AAC75817 EnsemblBacteria AAC75817 http://www.ensemblgenomes.org/id/AAC75817 EnsemblBacteria BAA16570 http://www.ensemblgenomes.org/id/BAA16570 EnsemblBacteria BAA16570 http://www.ensemblgenomes.org/id/BAA16570 EnsemblBacteria BAA16570 http://www.ensemblgenomes.org/id/BAA16570 EnsemblBacteria b2775 http://www.ensemblgenomes.org/id/b2775 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 947248 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947248 HOGENOM HOG000124124 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000124124&db=HOGENOM6 IntAct P77031 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77031* InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Gene ecj:JW2746 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2746 KEGG_Gene eco:b2775 http://www.genome.jp/dbget-bin/www_bget?eco:b2775 MINT MINT-1248595 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1248595 OMA NIVPNLH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NIVPNLH PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:YQCE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQCE_ECOLI PSORT-B swissprot:YQCE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQCE_ECOLI PSORT2 swissprot:YQCE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQCE_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:YQCE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQCE_ECOLI PhylomeDB P77031 http://phylomedb.org/?seqid=P77031 ProteinModelPortal P77031 http://www.proteinmodelportal.org/query/uniprot/P77031 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417255 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417255 RefSeq WP_001164544 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001164544 STRING 511145.b2775 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2775&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 UniProtKB YQCE_ECOLI http://www.uniprot.org/uniprot/YQCE_ECOLI UniProtKB-AC P77031 http://www.uniprot.org/uniprot/P77031 charge swissprot:YQCE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQCE_ECOLI eggNOG ENOG4108ITV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ITV eggNOG ENOG410Y8F9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y8F9 epestfind swissprot:YQCE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQCE_ECOLI garnier swissprot:YQCE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQCE_ECOLI helixturnhelix swissprot:YQCE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQCE_ECOLI hmoment swissprot:YQCE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQCE_ECOLI iep swissprot:YQCE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQCE_ECOLI inforesidue swissprot:YQCE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQCE_ECOLI octanol swissprot:YQCE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQCE_ECOLI pepcoil swissprot:YQCE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQCE_ECOLI pepdigest swissprot:YQCE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQCE_ECOLI pepinfo swissprot:YQCE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQCE_ECOLI pepnet swissprot:YQCE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQCE_ECOLI pepstats swissprot:YQCE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQCE_ECOLI pepwheel swissprot:YQCE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQCE_ECOLI pepwindow swissprot:YQCE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQCE_ECOLI sigcleave swissprot:YQCE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQCE_ECOLI ## Database ID URL or Descriptions # BioGrid 4260153 289 # EcoGene EG13906 mpaA # GO_function GO:0004040 amidase activity; IGI:EcoliWiki. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_function GO:0061473 murein tripeptide carboxypeptidase activity; IDA:EcoCyc. # GO_process GO:0009050 glycopeptide catabolic process; IMP:EcoCyc. # GO_process GO:0009253 peptidoglycan catabolic process; IMP:EcoCyc. # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # IntAct P0ACV6 4 # InterPro IPR000834 Peptidase_M14 # Organism MPAA_ECOLI Escherichia coli (strain K12) # PATRIC 32117926 VBIEscCol129921_1383 # PIR A64882 A64882 # Pfam PF00246 Peptidase_M14 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MPAA_ECOLI Protein MpaA # RefSeq NP_415842 NC_000913.3 # RefSeq WP_000219122 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA14908.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # eggNOG COG2866 LUCA # eggNOG ENOG4105KXI Bacteria BLAST swissprot:MPAA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MPAA_ECOLI BioCyc ECOL316407:JW1319-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1319-MONOMER BioCyc EcoCyc:G6662-MONOMER http://biocyc.org/getid?id=EcoCyc:G6662-MONOMER BioCyc MetaCyc:G6662-MONOMER http://biocyc.org/getid?id=MetaCyc:G6662-MONOMER COG COG2866 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2866 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.270.48.28635 http://dx.doi.org/10.1074/jbc.270.48.28635 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U33213 http://www.ebi.ac.uk/ena/data/view/U33213 EchoBASE EB3665 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3665 EcoGene EG13906 http://www.ecogene.org/geneInfo.php?eg_id=EG13906 EnsemblBacteria AAC74408 http://www.ensemblgenomes.org/id/AAC74408 EnsemblBacteria AAC74408 http://www.ensemblgenomes.org/id/AAC74408 EnsemblBacteria BAA14908 http://www.ensemblgenomes.org/id/BAA14908 EnsemblBacteria BAA14908 http://www.ensemblgenomes.org/id/BAA14908 EnsemblBacteria BAA14908 http://www.ensemblgenomes.org/id/BAA14908 EnsemblBacteria b1326 http://www.ensemblgenomes.org/id/b1326 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004040 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004040 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0061473 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061473 GO_process GO:0009050 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009050 GO_process GO:0009253 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009253 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 945969 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945969 HOGENOM HOG000120119 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120119&db=HOGENOM6 IntAct P0ACV6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACV6* InterPro IPR000834 http://www.ebi.ac.uk/interpro/entry/IPR000834 KEGG_Gene ecj:JW1319 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1319 KEGG_Gene eco:b1326 http://www.genome.jp/dbget-bin/www_bget?eco:b1326 KEGG_Orthology KO:K14054 http://www.genome.jp/dbget-bin/www_bget?KO:K14054 PSORT swissprot:MPAA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MPAA_ECOLI PSORT-B swissprot:MPAA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MPAA_ECOLI PSORT2 swissprot:MPAA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MPAA_ECOLI Pfam PF00246 http://pfam.xfam.org/family/PF00246 Phobius swissprot:MPAA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MPAA_ECOLI ProteinModelPortal P0ACV6 http://www.proteinmodelportal.org/query/uniprot/P0ACV6 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7499381 http://www.ncbi.nlm.nih.gov/pubmed/7499381 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415842 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415842 RefSeq WP_000219122 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000219122 SMR P0ACV6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACV6 STRING 511145.b1326 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1326&targetmode=cogs STRING COG2866 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2866&targetmode=cogs UniProtKB MPAA_ECOLI http://www.uniprot.org/uniprot/MPAA_ECOLI UniProtKB-AC P0ACV6 http://www.uniprot.org/uniprot/P0ACV6 charge swissprot:MPAA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MPAA_ECOLI eggNOG COG2866 http://eggnogapi.embl.de/nog_data/html/tree/COG2866 eggNOG ENOG4105KXI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KXI epestfind swissprot:MPAA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MPAA_ECOLI garnier swissprot:MPAA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MPAA_ECOLI helixturnhelix swissprot:MPAA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MPAA_ECOLI hmoment swissprot:MPAA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MPAA_ECOLI iep swissprot:MPAA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MPAA_ECOLI inforesidue swissprot:MPAA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MPAA_ECOLI octanol swissprot:MPAA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MPAA_ECOLI pepcoil swissprot:MPAA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MPAA_ECOLI pepdigest swissprot:MPAA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MPAA_ECOLI pepinfo swissprot:MPAA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MPAA_ECOLI pepnet swissprot:MPAA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MPAA_ECOLI pepstats swissprot:MPAA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MPAA_ECOLI pepwheel swissprot:MPAA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MPAA_ECOLI pepwindow swissprot:MPAA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MPAA_ECOLI sigcleave swissprot:MPAA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MPAA_ECOLI ## Database ID URL or Descriptions # AltName NADH dehydrogenase I subunit A {ECO:0000255|HAMAP-Rule MF_01394} # AltName NDH-1 subunit A {ECO:0000255|HAMAP-Rule MF_01394} # AltName NUO1 {ECO:0000255|HAMAP-Rule MF_01394} # BioGrid 4262974 23 # CATALYTIC ACTIVITY NADH + a quinone = NAD(+) + a quinol. {ECO:0000255|HAMAP-Rule MF_01394}. # EcoGene EG12082 nuoA # FUNCTION NUOA_ECOLI NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0030964 NADH dehydrogenase complex; IDA:EcoliWiki. # GO_component GO:0045272 plasma membrane respiratory chain complex I; IDA:EcoCyc. # GO_function GO:0008137 NADH dehydrogenase (ubiquinone) activity; IMP:EcoCyc. # GO_function GO:0048038 quinone binding; IEA:UniProtKB-KW. # GO_process GO:0006810 transport; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006810 transport # HAMAP MF_01394 NDH1_NuoA # InterPro IPR000440 NADH_UbQ/plastoQ_OxRdtase_su3 # InterPro IPR023043 NAD(P)H_OxRDtase_bac/plastid # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00190 Oxidative phosphorylation # KEGG_Pathway ko00910 Nitrogen metabolism # Organism NUOA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11058 PTHR11058 # PATRIC 32119943 VBIEscCol129921_2381 # PIR F65000 F65000 # Pfam PF00507 Oxidored_q4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NADH-quinone oxidoreductase subunit A {ECO:0000255|HAMAP-Rule MF_01394} # RefSeq NP_416791 NC_000913.3 # RefSeq WP_000062997 NZ_LN832404.1 # SIMILARITY Belongs to the complex I subunit 3 family. {ECO:0000255|HAMAP-Rule MF_01394}. # SUBCELLULAR LOCATION NUOA_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01394, ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255|HAMAP-Rule MF_01394, ECO 0000269|PubMed 15919996}. # SUBUNIT NUOA_ECOLI NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex. # TCDB 3.D.1.1 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family # eggNOG COG0838 LUCA # eggNOG ENOG4105KWU Bacteria BLAST swissprot:NUOA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NUOA_ECOLI BioCyc ECOL316407:JW2283-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2283-MONOMER BioCyc EcoCyc:NUOA-MONOMER http://biocyc.org/getid?id=EcoCyc:NUOA-MONOMER BioCyc MetaCyc:NUOA-MONOMER http://biocyc.org/getid?id=MetaCyc:NUOA-MONOMER COG COG0838 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0838 DIP DIP-59257N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-59257N DOI 10.1006/jmbi.1993.1488 http://dx.doi.org/10.1006/jmbi.1993.1488 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.6.5.11 {ECO:0000255|HAMAP-Rule:MF_01394} http://www.genome.jp/dbget-bin/www_bget?EC:1.6.5.11 {ECO:0000255|HAMAP-Rule:MF_01394} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X68301 http://www.ebi.ac.uk/ena/data/view/X68301 ENZYME 1.6.5.11 {ECO:0000255|HAMAP-Rule:MF_01394} http://enzyme.expasy.org/EC/1.6.5.11 {ECO:0000255|HAMAP-Rule:MF_01394} EchoBASE EB2007 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2007 EcoGene EG12082 http://www.ecogene.org/geneInfo.php?eg_id=EG12082 EnsemblBacteria AAC75348 http://www.ensemblgenomes.org/id/AAC75348 EnsemblBacteria AAC75348 http://www.ensemblgenomes.org/id/AAC75348 EnsemblBacteria BAA16123 http://www.ensemblgenomes.org/id/BAA16123 EnsemblBacteria BAA16123 http://www.ensemblgenomes.org/id/BAA16123 EnsemblBacteria BAA16123 http://www.ensemblgenomes.org/id/BAA16123 EnsemblBacteria b2288 http://www.ensemblgenomes.org/id/b2288 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0030964 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030964 GO_component GO:0045272 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045272 GO_function GO:0008137 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008137 GO_function GO:0048038 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048038 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 946764 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946764 HAMAP MF_01394 http://hamap.expasy.org/unirule/MF_01394 HOGENOM HOG000100121 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000100121&db=HOGENOM6 InParanoid P0AFC3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFC3 IntEnz 1.6.5.11 {ECO:0000255|HAMAP-Rule:MF_01394} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.6.5.11 {ECO:0000255|HAMAP-Rule:MF_01394} InterPro IPR000440 http://www.ebi.ac.uk/interpro/entry/IPR000440 InterPro IPR023043 http://www.ebi.ac.uk/interpro/entry/IPR023043 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2283 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2283 KEGG_Gene eco:b2288 http://www.genome.jp/dbget-bin/www_bget?eco:b2288 KEGG_Orthology KO:K00330 http://www.genome.jp/dbget-bin/www_bget?KO:K00330 KEGG_Pathway ko00190 http://www.genome.jp/kegg-bin/show_pathway?ko00190 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Reaction rn:R02166 http://www.genome.jp/dbget-bin/www_bget?rn:R02166 OMA WVGFIEA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WVGFIEA PANTHER PTHR11058 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11058 PSORT swissprot:NUOA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NUOA_ECOLI PSORT-B swissprot:NUOA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NUOA_ECOLI PSORT2 swissprot:NUOA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NUOA_ECOLI Pfam PF00507 http://pfam.xfam.org/family/PF00507 Phobius swissprot:NUOA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NUOA_ECOLI PhylomeDB P0AFC3 http://phylomedb.org/?seqid=P0AFC3 ProteinModelPortal P0AFC3 http://www.proteinmodelportal.org/query/uniprot/P0AFC3 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7690854 http://www.ncbi.nlm.nih.gov/pubmed/7690854 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416791 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416791 RefSeq WP_000062997 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000062997 SMR P0AFC3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFC3 STRING 511145.b2288 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2288&targetmode=cogs STRING COG0838 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0838&targetmode=cogs TCDB 3.D.1.1 http://www.tcdb.org/search/result.php?tc=3.D.1.1 UniProtKB NUOA_ECOLI http://www.uniprot.org/uniprot/NUOA_ECOLI UniProtKB-AC P0AFC3 http://www.uniprot.org/uniprot/P0AFC3 charge swissprot:NUOA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NUOA_ECOLI eggNOG COG0838 http://eggnogapi.embl.de/nog_data/html/tree/COG0838 eggNOG ENOG4105KWU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KWU epestfind swissprot:NUOA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NUOA_ECOLI garnier swissprot:NUOA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NUOA_ECOLI helixturnhelix swissprot:NUOA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NUOA_ECOLI hmoment swissprot:NUOA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NUOA_ECOLI iep swissprot:NUOA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NUOA_ECOLI inforesidue swissprot:NUOA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NUOA_ECOLI octanol swissprot:NUOA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NUOA_ECOLI pepcoil swissprot:NUOA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NUOA_ECOLI pepdigest swissprot:NUOA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NUOA_ECOLI pepinfo swissprot:NUOA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NUOA_ECOLI pepnet swissprot:NUOA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NUOA_ECOLI pepstats swissprot:NUOA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NUOA_ECOLI pepwheel swissprot:NUOA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NUOA_ECOLI pepwindow swissprot:NUOA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NUOA_ECOLI sigcleave swissprot:NUOA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NUOA_ECOLI ## Database ID URL or Descriptions # AltName PNCA_ECOLI Nicotine deamidase # BioGrid 4262963 17 # CATALYTIC ACTIVITY PNCA_ECOLI Nicotinamide + H(2)O = nicotinate + NH(3). # EcoGene EG11135 pncA # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_component GO:0005829 cytosol; TAS:Reactome. # GO_function GO:0008936 nicotinamidase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006769 nicotinamide metabolic process; IBA:GO_Central. # GO_process GO:0019363 pyridine nucleotide biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0019674 NAD metabolic process; IBA:GO_Central. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.850 -; 1. # IntAct P21369 4 # InterPro IPR000868 Isochorismatase-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00760 Nicotinate and nicotinamide metabolism # Organism PNCA_ECOLI Escherichia coli (strain K12) # PATHWAY Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide step 1/1. # PATRIC 32118847 VBIEscCol129921_1841 # PIR H64936 QQECA5 # Pfam PF00857 Isochorismatase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PNCA_ECOLI Pyrazinamidase/nicotinamidase # RefSeq NP_416282 NC_000913.3 # RefSeq WP_001135066 NZ_LN832404.1 # SIMILARITY Belongs to the PncA family. {ECO 0000305}. # SUPFAM SSF52499 SSF52499 # UniPathway UPA00830 UER00790 # eggNOG COG1335 LUCA # eggNOG ENOG4108RWI Bacteria BLAST swissprot:PNCA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PNCA_ECOLI BioCyc ECOL316407:JW1757-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1757-MONOMER BioCyc EcoCyc:NICOTINAMID-MONOMER http://biocyc.org/getid?id=EcoCyc:NICOTINAMID-MONOMER BioCyc MetaCyc:NICOTINAMID-MONOMER http://biocyc.org/getid?id=MetaCyc:NICOTINAMID-MONOMER COG COG1335 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1335 DIP DIP-10520N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10520N DOI 10.1016/0378-1119(89)90312-0 http://dx.doi.org/10.1016/0378-1119(89)90312-0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.5.1.- http://www.genome.jp/dbget-bin/www_bget?EC:3.5.1.- EC_number EC:3.5.1.19 http://www.genome.jp/dbget-bin/www_bget?EC:3.5.1.19 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M26934 http://www.ebi.ac.uk/ena/data/view/M26934 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.5.1.- http://enzyme.expasy.org/EC/3.5.1.- ENZYME 3.5.1.19 http://enzyme.expasy.org/EC/3.5.1.19 EchoBASE EB1125 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1125 EcoGene EG11135 http://www.ecogene.org/geneInfo.php?eg_id=EG11135 EnsemblBacteria AAC74838 http://www.ensemblgenomes.org/id/AAC74838 EnsemblBacteria AAC74838 http://www.ensemblgenomes.org/id/AAC74838 EnsemblBacteria BAA15559 http://www.ensemblgenomes.org/id/BAA15559 EnsemblBacteria BAA15559 http://www.ensemblgenomes.org/id/BAA15559 EnsemblBacteria BAA15559 http://www.ensemblgenomes.org/id/BAA15559 EnsemblBacteria b1768 http://www.ensemblgenomes.org/id/b1768 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008936 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008936 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006769 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006769 GO_process GO:0019363 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019363 GO_process GO:0019674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019674 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.850 http://www.cathdb.info/version/latest/superfamily/3.40.50.850 GeneID 946276 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946276 HOGENOM HOG000078666 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000078666&db=HOGENOM6 InParanoid P21369 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P21369 IntAct P21369 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P21369* IntEnz 3.5.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.1 IntEnz 3.5.1.19 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.1.19 InterPro IPR000868 http://www.ebi.ac.uk/interpro/entry/IPR000868 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1757 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1757 KEGG_Gene eco:b1768 http://www.genome.jp/dbget-bin/www_bget?eco:b1768 KEGG_Orthology KO:K08281 http://www.genome.jp/dbget-bin/www_bget?KO:K08281 KEGG_Pathway ko00760 http://www.genome.jp/kegg-bin/show_pathway?ko00760 KEGG_Reaction rn:R01268 http://www.genome.jp/dbget-bin/www_bget?rn:R01268 OMA DSWPPHC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DSWPPHC PSORT swissprot:PNCA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PNCA_ECOLI PSORT-B swissprot:PNCA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PNCA_ECOLI PSORT2 swissprot:PNCA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PNCA_ECOLI Pfam PF00857 http://pfam.xfam.org/family/PF00857 Phobius swissprot:PNCA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PNCA_ECOLI PhylomeDB P21369 http://phylomedb.org/?seqid=P21369 ProteinModelPortal P21369 http://www.proteinmodelportal.org/query/uniprot/P21369 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2670682 http://www.ncbi.nlm.nih.gov/pubmed/2670682 PubMed 8726014 http://www.ncbi.nlm.nih.gov/pubmed/8726014 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416282 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416282 RefSeq WP_001135066 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001135066 SMR P21369 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P21369 STRING 511145.b1768 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1768&targetmode=cogs STRING COG1335 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1335&targetmode=cogs SUPFAM SSF52499 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52499 UniProtKB PNCA_ECOLI http://www.uniprot.org/uniprot/PNCA_ECOLI UniProtKB-AC P21369 http://www.uniprot.org/uniprot/P21369 charge swissprot:PNCA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PNCA_ECOLI eggNOG COG1335 http://eggnogapi.embl.de/nog_data/html/tree/COG1335 eggNOG ENOG4108RWI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108RWI epestfind swissprot:PNCA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PNCA_ECOLI garnier swissprot:PNCA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PNCA_ECOLI helixturnhelix swissprot:PNCA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PNCA_ECOLI hmoment swissprot:PNCA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PNCA_ECOLI iep swissprot:PNCA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PNCA_ECOLI inforesidue swissprot:PNCA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PNCA_ECOLI octanol swissprot:PNCA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PNCA_ECOLI pepcoil swissprot:PNCA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PNCA_ECOLI pepdigest swissprot:PNCA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PNCA_ECOLI pepinfo swissprot:PNCA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PNCA_ECOLI pepnet swissprot:PNCA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PNCA_ECOLI pepstats swissprot:PNCA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PNCA_ECOLI pepwheel swissprot:PNCA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PNCA_ECOLI pepwindow swissprot:PNCA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PNCA_ECOLI sigcleave swissprot:PNCA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PNCA_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES GPR_ECOLI Kinetic parameters KM=1.06 mM for 4-nitrobenzaldehyde (at pH 7 and at 25 degrees Celsius) {ECO 0000269|PubMed 16077126}; KM=3.4 mM for methylglyoxal (at pH 7 and at 25 degrees Celsius) {ECO 0000269|PubMed 16077126}; # BioGrid 4261416 9 # CDD cd06660 Aldo_ket_red # DISRUPTION PHENOTYPE GPR_ECOLI Cells lacking this gene show 23% decrease in the amount of acetol. # EcoGene EG13010 gpr # FUNCTION GPR_ECOLI Catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). The physiological role of gpr is the detoxification of L-GAP, which may be formed by non- enzymatic racemization of GAP. Also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. {ECO 0000269|PubMed 12583903, ECO 0000269|PubMed 16077126, ECO 0000269|PubMed 18620424}. # GO_function GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IDA:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0009438 methylglyoxal metabolic process; IDA:EcoCyc. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006950 response to stress # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.100 -; 1. # IntAct Q46851 6 # InterPro IPR001395 Aldo/ket_red/Kv-b # InterPro IPR023210 NADP_OxRdtase_dom # Organism GPR_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11732 PTHR11732 # PATRIC 32121420 VBIEscCol129921_3097 # PDB 3N6Q X-ray; 1.80 A; A/B/C/D/E/F/G/H=1-346 # PDB 4AST X-ray; 2.38 A; A/B/C/D/E/F/G/H=1-346 # PDB 4AUB X-ray; 2.05 A; A/B/C/D/E/F/G/H=1-346 # PIR G65086 G65086 # Pfam PF00248 Aldo_ket_red # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GPR_ECOLI L-glyceraldehyde 3-phosphate reductase # RefSeq NP_417474 NC_000913.3 # RefSeq WP_000262172 NZ_LN832404.1 # SIMILARITY Belongs to the shaker potassium channel beta subunit family. {ECO 0000305}. # SUBUNIT Homotetramer. {ECO:0000269|PubMed 22393408}. # SUPFAM SSF51430 SSF51430 # eggNOG COG0667 LUCA # eggNOG ENOG4105CPC Bacteria BLAST swissprot:GPR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GPR_ECOLI BioCyc ECOL316407:JW2970-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2970-MONOMER BioCyc EcoCyc:G7558-MONOMER http://biocyc.org/getid?id=EcoCyc:G7558-MONOMER BioCyc MetaCyc:G7558-MONOMER http://biocyc.org/getid?id=MetaCyc:G7558-MONOMER DIP DIP-36026N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36026N DOI 10.1021/bi801054v http://dx.doi.org/10.1021/bi801054v DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1574-6968.2003.tb11503.x http://dx.doi.org/10.1111/j.1574-6968.2003.tb11503.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.187.16.5782-5789.2005 http://dx.doi.org/10.1128/JB.187.16.5782-5789.2005 DOI 10.1371/journal.pone.0032498 http://dx.doi.org/10.1371/journal.pone.0032498 EC_number EC:1.1.1.- http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 ENZYME 1.1.1.- http://enzyme.expasy.org/EC/1.1.1.- EchoBASE EB2831 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2831 EcoGene EG13010 http://www.ecogene.org/geneInfo.php?eg_id=EG13010 EnsemblBacteria AAC76037 http://www.ensemblgenomes.org/id/AAC76037 EnsemblBacteria AAC76037 http://www.ensemblgenomes.org/id/AAC76037 EnsemblBacteria BAE77060 http://www.ensemblgenomes.org/id/BAE77060 EnsemblBacteria BAE77060 http://www.ensemblgenomes.org/id/BAE77060 EnsemblBacteria BAE77060 http://www.ensemblgenomes.org/id/BAE77060 EnsemblBacteria b3001 http://www.ensemblgenomes.org/id/b3001 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016616 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016616 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0009438 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009438 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.100 http://www.cathdb.info/version/latest/superfamily/3.20.20.100 GeneID 947480 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947480 HOGENOM HOG000250283 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000250283&db=HOGENOM6 InParanoid Q46851 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46851 IntAct Q46851 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46851* IntEnz 1.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1 InterPro IPR001395 http://www.ebi.ac.uk/interpro/entry/IPR001395 InterPro IPR023210 http://www.ebi.ac.uk/interpro/entry/IPR023210 KEGG_Gene ecj:JW2970 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2970 KEGG_Gene eco:b3001 http://www.genome.jp/dbget-bin/www_bget?eco:b3001 OMA WHSFGHV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WHSFGHV PANTHER PTHR11732 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11732 PDB 3N6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/3N6Q PDB 4AST http://www.ebi.ac.uk/pdbe-srv/view/entry/4AST PDB 4AUB http://www.ebi.ac.uk/pdbe-srv/view/entry/4AUB PDBsum 3N6Q http://www.ebi.ac.uk/pdbsum/3N6Q PDBsum 4AST http://www.ebi.ac.uk/pdbsum/4AST PDBsum 4AUB http://www.ebi.ac.uk/pdbsum/4AUB PSORT swissprot:GPR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GPR_ECOLI PSORT-B swissprot:GPR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GPR_ECOLI PSORT2 swissprot:GPR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GPR_ECOLI Pfam PF00248 http://pfam.xfam.org/family/PF00248 Phobius swissprot:GPR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GPR_ECOLI PhylomeDB Q46851 http://phylomedb.org/?seqid=Q46851 ProteinModelPortal Q46851 http://www.proteinmodelportal.org/query/uniprot/Q46851 PubMed 12583903 http://www.ncbi.nlm.nih.gov/pubmed/12583903 PubMed 16077126 http://www.ncbi.nlm.nih.gov/pubmed/16077126 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18620424 http://www.ncbi.nlm.nih.gov/pubmed/18620424 PubMed 22393408 http://www.ncbi.nlm.nih.gov/pubmed/22393408 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417474 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417474 RefSeq WP_000262172 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000262172 SMR Q46851 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46851 STRING 511145.b3001 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3001&targetmode=cogs SUPFAM SSF51430 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51430 UniProtKB GPR_ECOLI http://www.uniprot.org/uniprot/GPR_ECOLI UniProtKB-AC Q46851 http://www.uniprot.org/uniprot/Q46851 charge swissprot:GPR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GPR_ECOLI eggNOG COG0667 http://eggnogapi.embl.de/nog_data/html/tree/COG0667 eggNOG ENOG4105CPC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CPC epestfind swissprot:GPR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GPR_ECOLI garnier swissprot:GPR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GPR_ECOLI helixturnhelix swissprot:GPR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GPR_ECOLI hmoment swissprot:GPR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GPR_ECOLI iep swissprot:GPR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GPR_ECOLI inforesidue swissprot:GPR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GPR_ECOLI octanol swissprot:GPR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GPR_ECOLI pepcoil swissprot:GPR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GPR_ECOLI pepdigest swissprot:GPR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GPR_ECOLI pepinfo swissprot:GPR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GPR_ECOLI pepnet swissprot:GPR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GPR_ECOLI pepstats swissprot:GPR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GPR_ECOLI pepwheel swissprot:GPR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GPR_ECOLI pepwindow swissprot:GPR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GPR_ECOLI sigcleave swissprot:GPR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GPR_ECOLI ## Database ID URL or Descriptions # EcoGene EG13722 yccT # HAMAP MF_00789 UPF0319 # IntAct P0A8X4 5 # InterPro IPR018635 UPF0319 # Organism YCCT_ECOLI Escherichia coli (strain K12) # PATRIC 32117147 VBIEscCol129921_0998 # PIR C64837 C64837 # Pfam PF09829 DUF2057 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCCT_ECOLI UPF0319 protein YccT # RefSeq NP_415484 NC_000913.3 # RefSeq WP_000847791 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0319 family. {ECO 0000305}. # eggNOG COG3110 LUCA # eggNOG ENOG4108Q67 Bacteria BLAST swissprot:YCCT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCCT_ECOLI BioCyc ECOL316407:JW0947-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0947-MONOMER BioCyc EcoCyc:G6498-MONOMER http://biocyc.org/getid?id=EcoCyc:G6498-MONOMER COG COG3110 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3110 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3486 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3486 EcoGene EG13722 http://www.ecogene.org/geneInfo.php?eg_id=EG13722 EnsemblBacteria AAC74050 http://www.ensemblgenomes.org/id/AAC74050 EnsemblBacteria AAC74050 http://www.ensemblgenomes.org/id/AAC74050 EnsemblBacteria BAA35729 http://www.ensemblgenomes.org/id/BAA35729 EnsemblBacteria BAA35729 http://www.ensemblgenomes.org/id/BAA35729 EnsemblBacteria BAA35729 http://www.ensemblgenomes.org/id/BAA35729 EnsemblBacteria b0964 http://www.ensemblgenomes.org/id/b0964 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945577 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945577 HAMAP MF_00789 http://hamap.expasy.org/unirule/MF_00789 HOGENOM HOG000219325 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219325&db=HOGENOM6 IntAct P0A8X4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8X4* InterPro IPR018635 http://www.ebi.ac.uk/interpro/entry/IPR018635 KEGG_Gene ecj:JW0947 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0947 KEGG_Gene eco:b0964 http://www.genome.jp/dbget-bin/www_bget?eco:b0964 KEGG_Orthology KO:K09909 http://www.genome.jp/dbget-bin/www_bget?KO:K09909 OMA YQQADKE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YQQADKE PSORT swissprot:YCCT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCCT_ECOLI PSORT-B swissprot:YCCT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCCT_ECOLI PSORT2 swissprot:YCCT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCCT_ECOLI Pfam PF09829 http://pfam.xfam.org/family/PF09829 Phobius swissprot:YCCT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCCT_ECOLI ProteinModelPortal P0A8X4 http://www.proteinmodelportal.org/query/uniprot/P0A8X4 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415484 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415484 RefSeq WP_000847791 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000847791 STRING 511145.b0964 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0964&targetmode=cogs STRING COG3110 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3110&targetmode=cogs UniProtKB YCCT_ECOLI http://www.uniprot.org/uniprot/YCCT_ECOLI UniProtKB-AC P0A8X4 http://www.uniprot.org/uniprot/P0A8X4 charge swissprot:YCCT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCCT_ECOLI eggNOG COG3110 http://eggnogapi.embl.de/nog_data/html/tree/COG3110 eggNOG ENOG4108Q67 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Q67 epestfind swissprot:YCCT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCCT_ECOLI garnier swissprot:YCCT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCCT_ECOLI helixturnhelix swissprot:YCCT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCCT_ECOLI hmoment swissprot:YCCT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCCT_ECOLI iep swissprot:YCCT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCCT_ECOLI inforesidue swissprot:YCCT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCCT_ECOLI octanol swissprot:YCCT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCCT_ECOLI pepcoil swissprot:YCCT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCCT_ECOLI pepdigest swissprot:YCCT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCCT_ECOLI pepinfo swissprot:YCCT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCCT_ECOLI pepnet swissprot:YCCT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCCT_ECOLI pepstats swissprot:YCCT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCCT_ECOLI pepwheel swissprot:YCCT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCCT_ECOLI pepwindow swissprot:YCCT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCCT_ECOLI sigcleave swissprot:YCCT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCCT_ECOLI ## Database ID URL or Descriptions # AltName EII-P-Man {ECO:0000303|PubMed 2951378} # AltName EIIC-Man {ECO:0000303|PubMed 2999119} # AltName Mannose permease IIC component {ECO:0000303|PubMed 2999119} # BioGrid 4259145 469 # DOMAIN PTNC_ECOLI The PTS EIIC type-4 domain forms the PTS system translocation channel and contains the specific substrate-binding site. {ECO 0000255|PROSITE-ProRule PRU00429}. # EcoGene EG10568 manY # FUNCTION PTNC_ECOLI The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (PubMed 2951378, PubMed 2999119). The enzyme II ManXYZ PTS system is involved in mannose transport (PubMed 2951378, PubMed 2999119). Also functions as a receptor for bacterial chemotaxis and is required for infection of the cell by bacteriophage lambda where it most likely functions as a pore for penetration of lambda DNA (PubMed 4604906, PubMed 353494). {ECO 0000269|PubMed 2951378, ECO 0000269|PubMed 2999119, ECO 0000269|PubMed 353494, ECO 0000269|PubMed 4604906}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; ISM:CACAO. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0022870 protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity; IDA:EcoCyc. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IDA:EcoCyc. # GO_process GO:0015761 mannose transport; IDA:EcoCyc. # GO_process GO:0061490 glucose import into cell; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR004700 PTS_IIC_man # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00276 PTS system, mannose-specific II component # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko00051 Fructose and mannose metabolism # KEGG_Pathway ko00520 Amino sugar and nucleotide sugar metabolism # KEGG_Pathway ko02060 Phosphotransferase system (PTS) # Organism PTNC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR32502:SF4 PTHR32502:SF4 # PATRIC 32118955 VBIEscCol129921_1895 # PIR A30285 WQECMP # PROSITE PS51106 PTS_EIIC_TYPE_4 # Pfam PF03609 EII-Sor # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PTS system mannose-specific EIIC component {ECO:0000303|PubMed 2999119} # RefSeq NP_416332 NC_000913.3 # RefSeq WP_000406926 NZ_LN832404.1 # SIMILARITY Contains 1 PTS EIIC type-4 domain. {ECO:0000255|PROSITE-ProRule PRU00429}. # SUBCELLULAR LOCATION PTNC_ECOLI Cell inner membrane {ECO 0000255|PROSITE- ProRule PRU00429, ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00429, ECO 0000269|PubMed 15919996}. # TCDB 4.A.6.1 the pts mannose-fructose-sorbose (man) family # TIGRFAMs TIGR00822 EII-Sor # eggNOG COG3715 LUCA # eggNOG ENOG4105ETZ Bacteria BLAST swissprot:PTNC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTNC_ECOLI BioCyc ECOL316407:JW1807-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1807-MONOMER BioCyc EcoCyc:MANY-MONOMER http://biocyc.org/getid?id=EcoCyc:MANY-MONOMER BioCyc MetaCyc:MANY-MONOMER http://biocyc.org/getid?id=MetaCyc:MANY-MONOMER COG COG3715 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3715 DOI 10.1007/BF00266608 http://dx.doi.org/10.1007/BF00266608 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.71.7.2895 http://dx.doi.org/10.1073/pnas.71.7.2895 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1111/j.1432-1033.1996.0810u.x http://dx.doi.org/10.1111/j.1432-1033.1996.0810u.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1515/bchm3.1994.375.8.551 http://dx.doi.org/10.1515/bchm3.1994.375.8.551 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J02699 http://www.ebi.ac.uk/ena/data/view/J02699 EMBL M36404 http://www.ebi.ac.uk/ena/data/view/M36404 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0563 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0563 EcoGene EG10568 http://www.ecogene.org/geneInfo.php?eg_id=EG10568 EnsemblBacteria AAC74888 http://www.ensemblgenomes.org/id/AAC74888 EnsemblBacteria AAC74888 http://www.ensemblgenomes.org/id/AAC74888 EnsemblBacteria BAA15625 http://www.ensemblgenomes.org/id/BAA15625 EnsemblBacteria BAA15625 http://www.ensemblgenomes.org/id/BAA15625 EnsemblBacteria BAA15625 http://www.ensemblgenomes.org/id/BAA15625 EnsemblBacteria b1818 http://www.ensemblgenomes.org/id/b1818 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0022870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022870 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GO_process GO:0015761 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015761 GO_process GO:0061490 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061490 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 946332 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946332 HOGENOM HOG000097554 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000097554&db=HOGENOM6 InParanoid P69801 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P69801 IntAct P69801 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69801* InterPro IPR004700 http://www.ebi.ac.uk/interpro/entry/IPR004700 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1807 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1807 KEGG_Gene eco:b1818 http://www.genome.jp/dbget-bin/www_bget?eco:b1818 KEGG_Orthology KO:K02795 http://www.genome.jp/dbget-bin/www_bget?KO:K02795 KEGG_Pathway ko00051 http://www.genome.jp/kegg-bin/show_pathway?ko00051 KEGG_Pathway ko00520 http://www.genome.jp/kegg-bin/show_pathway?ko00520 KEGG_Pathway ko02060 http://www.genome.jp/kegg-bin/show_pathway?ko02060 KEGG_Reaction rn:R02630 http://www.genome.jp/dbget-bin/www_bget?rn:R02630 OMA ACIAGMD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ACIAGMD PANTHER PTHR32502:SF4 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32502:SF4 PROSITE PS51106 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51106 PSORT swissprot:PTNC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTNC_ECOLI PSORT-B swissprot:PTNC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTNC_ECOLI PSORT2 swissprot:PTNC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTNC_ECOLI Pfam PF03609 http://pfam.xfam.org/family/PF03609 Phobius swissprot:PTNC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTNC_ECOLI PhylomeDB P69801 http://phylomedb.org/?seqid=P69801 ProteinModelPortal P69801 http://www.proteinmodelportal.org/query/uniprot/P69801 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2951378 http://www.ncbi.nlm.nih.gov/pubmed/2951378 PubMed 2999119 http://www.ncbi.nlm.nih.gov/pubmed/2999119 PubMed 353494 http://www.ncbi.nlm.nih.gov/pubmed/353494 PubMed 4604906 http://www.ncbi.nlm.nih.gov/pubmed/4604906 PubMed 7811395 http://www.ncbi.nlm.nih.gov/pubmed/7811395 PubMed 8774730 http://www.ncbi.nlm.nih.gov/pubmed/8774730 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416332 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416332 RefSeq WP_000406926 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000406926 STRING 511145.b1818 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1818&targetmode=cogs STRING COG3715 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3715&targetmode=cogs TCDB 4.A.6.1 http://www.tcdb.org/search/result.php?tc=4.A.6.1 TIGRFAMs TIGR00822 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00822 UniProtKB PTNC_ECOLI http://www.uniprot.org/uniprot/PTNC_ECOLI UniProtKB-AC P69801 http://www.uniprot.org/uniprot/P69801 charge swissprot:PTNC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTNC_ECOLI eggNOG COG3715 http://eggnogapi.embl.de/nog_data/html/tree/COG3715 eggNOG ENOG4105ETZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ETZ epestfind swissprot:PTNC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTNC_ECOLI garnier swissprot:PTNC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTNC_ECOLI helixturnhelix swissprot:PTNC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTNC_ECOLI hmoment swissprot:PTNC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTNC_ECOLI iep swissprot:PTNC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTNC_ECOLI inforesidue swissprot:PTNC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTNC_ECOLI octanol swissprot:PTNC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTNC_ECOLI pepcoil swissprot:PTNC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTNC_ECOLI pepdigest swissprot:PTNC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTNC_ECOLI pepinfo swissprot:PTNC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTNC_ECOLI pepnet swissprot:PTNC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTNC_ECOLI pepstats swissprot:PTNC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTNC_ECOLI pepwheel swissprot:PTNC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTNC_ECOLI pepwindow swissprot:PTNC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTNC_ECOLI sigcleave swissprot:PTNC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTNC_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES TMCA_ECOLI Kinetic parameters KM=2.93 uM for ATP (in the absence of both acetyl-CoA and tRNA(Met)) {ECO 0000269|PubMed 18668122}; KM=4.16 uM for ATP (in the presence of both acetyl-CoA and tRNA(Met)) {ECO 0000269|PubMed 18668122}; KM=117 uM for GTP (in the absence of both acetyl-CoA and tRNA(Met)) {ECO 0000269|PubMed 18668122}; KM=66.6 uM for GTP (in the presence of both acetyl-CoA and tRNA(Met)) {ECO 0000269|PubMed 18668122}; # BRENDA 2.3.1.193 2026 # BioGrid 4259195 17 # CATALYTIC ACTIVITY TMCA_ECOLI (Elongator tRNA(Met))-cytidine(34) + ATP + acetyl-CoA + H(2)O = (elongator tRNA(Met))-N(4)-acetylcytidine(34) + ADP + phosphate + CoA. {ECO 0000255|HAMAP-Rule MF_01886, ECO 0000269|PubMed 18668122, ECO 0000269|PubMed 19322199}. # DISRUPTION PHENOTYPE Mutants lack the ac(4)C modification, but do not show any growth defects. {ECO:0000269|PubMed 18668122}. # ENZYME REGULATION TMCA_ECOLI ATP/GTP hydrolysis is stimulated by the addition of acetyl-CoA and tRNA(Met). Binding of acetyl-CoA to TmcA activates both ATPase and tRNA-binding activities. {ECO 0000269|PubMed 18668122, ECO 0000269|PubMed 19322199}. # EcoGene EG14196 tmcA # FUNCTION TMCA_ECOLI Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP). It recognizes the wobble base of tRNA(Met), thus distinguishing between tRNA(Met) and the structurally similar tRNA(Ile2). {ECO 0000255|HAMAP-Rule MF_01886, ECO 0000269|PubMed 18668122, ECO 0000269|PubMed 19322199}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0000049 tRNA binding; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0051392 tRNA N-acetyltransferase activity; IDA:EcoCyc. # GO_process GO:0002101 tRNA wobble cytosine modification; IMP:EcoCyc. # GO_process GO:0051391 tRNA acetylation; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # Gene3D 3.40.50.300 -; 1. # Gene3D 3.40.630.30 -; 2. # HAMAP MF_01886 tRNA_acetyltr_TmcA # IntAct P76562 8 # InterPro IPR000182 GNAT_dom # InterPro IPR007807 Helicase_dom # InterPro IPR013562 TmcA_N # InterPro IPR016181 Acyl_CoA_acyltransferase # InterPro IPR024914 tRNA_acetyltr_TmcA # InterPro IPR027417 P-loop_NTPase # InterPro IPR032672 TmcA/NAT10/Kre33 # InterPro IPR033442 TmcA_tRNA_bind # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # MISCELLANEOUS Could use an RNA helicase motor driven by ATP hydrolysis to deliver the wobble base of tRNA(Met) to the acetyltransferase domain of TmcA. {ECO:0000305|PubMed 19322199}. # Organism TMCA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10925 PTHR10925 # PATRIC 32120333 VBIEscCol129921_2569 # PDB 2ZPA X-ray; 2.35 A; A/B=1-671 # PIR A65023 A65023 # PROSITE PS51186 GNAT # Pfam PF05127 Helicase_RecD # Pfam PF08351 DUF1726 # Pfam PF13718 GNAT_acetyltr_2 # Pfam PF17176 tRNA_bind_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName tRNA(Met) cytidine acetyltransferase TmcA {ECO:0000255|HAMAP-Rule MF_01886} # RefSeq NP_416969 NC_000913.3 # RefSeq WP_000829360 NZ_LN832404.1 # SIMILARITY Belongs to the RNA cytidine acetyltransferase family. TmcA subfamily. {ECO:0000255|HAMAP-Rule MF_01886}. # SIMILARITY Contains 1 N-acetyltransferase domain. {ECO:0000255|HAMAP-Rule MF_01886}. # SUBCELLULAR LOCATION TMCA_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_01886}. # SUPFAM SSF52540 SSF52540 # SUPFAM SSF55729 SSF55729; 2 # eggNOG COG1444 LUCA # eggNOG ENOG4105E0I Bacteria BLAST swissprot:TMCA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TMCA_ECOLI BioCyc ECOL316407:JW2459-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2459-MONOMER BioCyc EcoCyc:G7297-MONOMER http://biocyc.org/getid?id=EcoCyc:G7297-MONOMER BioCyc MetaCyc:G7297-MONOMER http://biocyc.org/getid?id=MetaCyc:G7297-MONOMER COG COG1444 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1444 DIP DIP-12825N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12825N DOI 10.1038/emboj.2008.154 http://dx.doi.org/10.1038/emboj.2008.154 DOI 10.1038/emboj.2009.69 http://dx.doi.org/10.1038/emboj.2009.69 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.193 {ECO:0000255|HAMAP-Rule:MF_01886} http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.193 {ECO:0000255|HAMAP-Rule:MF_01886} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.3.1.193 {ECO:0000255|HAMAP-Rule:MF_01886} http://enzyme.expasy.org/EC/2.3.1.193 {ECO:0000255|HAMAP-Rule:MF_01886} EchoBASE EB3948 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3948 EcoGene EG14196 http://www.ecogene.org/geneInfo.php?eg_id=EG14196 EnsemblBacteria AAC75527 http://www.ensemblgenomes.org/id/AAC75527 EnsemblBacteria AAC75527 http://www.ensemblgenomes.org/id/AAC75527 EnsemblBacteria BAA16352 http://www.ensemblgenomes.org/id/BAA16352 EnsemblBacteria BAA16352 http://www.ensemblgenomes.org/id/BAA16352 EnsemblBacteria BAA16352 http://www.ensemblgenomes.org/id/BAA16352 EnsemblBacteria b2474 http://www.ensemblgenomes.org/id/b2474 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000049 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0051392 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051392 GO_process GO:0002101 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002101 GO_process GO:0051391 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051391 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 Gene3D 3.40.630.30 http://www.cathdb.info/version/latest/superfamily/3.40.630.30 GeneID 946053 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946053 HAMAP MF_01886 http://hamap.expasy.org/unirule/MF_01886 HOGENOM HOG000283762 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000283762&db=HOGENOM6 InParanoid P76562 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76562 IntAct P76562 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76562* IntEnz 2.3.1.193 {ECO:0000255|HAMAP-Rule:MF_01886} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.193 {ECO:0000255|HAMAP-Rule:MF_01886} InterPro IPR000182 http://www.ebi.ac.uk/interpro/entry/IPR000182 InterPro IPR007807 http://www.ebi.ac.uk/interpro/entry/IPR007807 InterPro IPR013562 http://www.ebi.ac.uk/interpro/entry/IPR013562 InterPro IPR016181 http://www.ebi.ac.uk/interpro/entry/IPR016181 InterPro IPR024914 http://www.ebi.ac.uk/interpro/entry/IPR024914 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR032672 http://www.ebi.ac.uk/interpro/entry/IPR032672 InterPro IPR033442 http://www.ebi.ac.uk/interpro/entry/IPR033442 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW2459 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2459 KEGG_Gene eco:b2474 http://www.genome.jp/dbget-bin/www_bget?eco:b2474 KEGG_Orthology KO:K06957 http://www.genome.jp/dbget-bin/www_bget?KO:K06957 OMA CSAHYRT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CSAHYRT PANTHER PTHR10925 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10925 PDB 2ZPA http://www.ebi.ac.uk/pdbe-srv/view/entry/2ZPA PDBsum 2ZPA http://www.ebi.ac.uk/pdbsum/2ZPA PROSITE PS51186 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51186 PSORT swissprot:TMCA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TMCA_ECOLI PSORT-B swissprot:TMCA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TMCA_ECOLI PSORT2 swissprot:TMCA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TMCA_ECOLI Pfam PF05127 http://pfam.xfam.org/family/PF05127 Pfam PF08351 http://pfam.xfam.org/family/PF08351 Pfam PF13718 http://pfam.xfam.org/family/PF13718 Pfam PF17176 http://pfam.xfam.org/family/PF17176 Phobius swissprot:TMCA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TMCA_ECOLI ProteinModelPortal P76562 http://www.proteinmodelportal.org/query/uniprot/P76562 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18668122 http://www.ncbi.nlm.nih.gov/pubmed/18668122 PubMed 19322199 http://www.ncbi.nlm.nih.gov/pubmed/19322199 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416969 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416969 RefSeq WP_000829360 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000829360 SMR P76562 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76562 STRING 511145.b2474 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2474&targetmode=cogs STRING COG1444 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1444&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SUPFAM SSF55729 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55729 UniProtKB TMCA_ECOLI http://www.uniprot.org/uniprot/TMCA_ECOLI UniProtKB-AC P76562 http://www.uniprot.org/uniprot/P76562 charge swissprot:TMCA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TMCA_ECOLI eggNOG COG1444 http://eggnogapi.embl.de/nog_data/html/tree/COG1444 eggNOG ENOG4105E0I http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E0I epestfind swissprot:TMCA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TMCA_ECOLI garnier swissprot:TMCA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TMCA_ECOLI helixturnhelix swissprot:TMCA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TMCA_ECOLI hmoment swissprot:TMCA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TMCA_ECOLI iep swissprot:TMCA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TMCA_ECOLI inforesidue swissprot:TMCA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TMCA_ECOLI octanol swissprot:TMCA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TMCA_ECOLI pepcoil swissprot:TMCA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TMCA_ECOLI pepdigest swissprot:TMCA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TMCA_ECOLI pepinfo swissprot:TMCA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TMCA_ECOLI pepnet swissprot:TMCA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TMCA_ECOLI pepstats swissprot:TMCA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TMCA_ECOLI pepwheel swissprot:TMCA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TMCA_ECOLI pepwindow swissprot:TMCA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TMCA_ECOLI sigcleave swissprot:TMCA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TMCA_ECOLI ## Database ID URL or Descriptions # AltName PUTP_ECOLI Proline permease # AltName PUTP_ECOLI Propionate transporter # BioGrid 4260051 9 # CDD cd11475 SLC5sbd_PutP # DISRUPTION PHENOTYPE Reduced growth rate when grown on propionate as sole carbon source. {ECO:0000269|PubMed 17088549}. # EcoGene EG10802 putP # FUNCTION PUTP_ECOLI Catalyzes the sodium-dependent uptake of extracellular L-proline. This protein is also capable of using lithium as the transport cation. Also catalyzes the uptake of propionate. {ECO 0000269|PubMed 17088549}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_function GO:0031402 sodium ion binding; IEA:InterPro. # GO_function PUTP_ECOLI GO 0005298 proline sodium symporter activity; IDA EcoCyc. # GO_process GO:0015824 proline transport; IDA:EcoCyc. # GO_process GO:0015912 short-chain fatty acid transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # INDUCTION Up-regulated by propionate. {ECO:0000269|PubMed 17088549}. # IntAct P07117 4 # InterPro IPR001734 Na/solute_symporter # InterPro IPR011851 Na/Pro_symporter # InterPro IPR018212 Na/solute_symporter_CS # Organism PUTP_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11819 PTHR11819 # PANTHER PTHR11819:SF148 PTHR11819:SF148 # PATRIC 32117263 VBIEscCol129921_1055 # PIR A30258 JGECPP # PROSITE PS00456 NA_SOLUT_SYMP_1 # PROSITE PS00457 NA_SOLUT_SYMP_2 # PROSITE PS50283 NA_SOLUT_SYMP_3 # Pfam PF00474 SSF # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PUTP_ECOLI Sodium/proline symporter # RefSeq NP_415535 NC_000913.3 # RefSeq WP_001018479 NZ_LN832404.1 # SIMILARITY Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. {ECO 0000305}. # SUBCELLULAR LOCATION PUTP_ECOLI Cell inner membrane {ECO 0000269|PubMed 16079137}; Multi-pass membrane protein {ECO 0000269|PubMed 16079137}. # SUBUNIT Has been isolated from inner membrane preparations as a homodimer. {ECO:0000269|PubMed 16079137}. # TCDB 2.A.21.2:the solute sodium symporter (sss) family # TIGRFAMs TIGR00813 sss # TIGRFAMs TIGR02121 Na_Pro_sym # eggNOG COG0591 LUCA # eggNOG ENOG4105CK7 Bacteria BLAST swissprot:PUTP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PUTP_ECOLI BioCyc ECOL316407:JW1001-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1001-MONOMER BioCyc EcoCyc:PUTP-MONOMER http://biocyc.org/getid?id=EcoCyc:PUTP-MONOMER BioCyc MetaCyc:PUTP-MONOMER http://biocyc.org/getid?id=MetaCyc:PUTP-MONOMER COG COG0591 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0591 DOI 10.1007/BF00325707 http://dx.doi.org/10.1007/BF00325707 DOI 10.1007/BF00330424 http://dx.doi.org/10.1007/BF00330424 DOI 10.1016/0005-2736(92)90162-F http://dx.doi.org/10.1016/0005-2736(92)90162-F DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0603364103 http://dx.doi.org/10.1073/pnas.0603364103 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L01150 http://www.ebi.ac.uk/ena/data/view/L01150 EMBL L01151 http://www.ebi.ac.uk/ena/data/view/L01151 EMBL M35174 http://www.ebi.ac.uk/ena/data/view/M35174 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X05653 http://www.ebi.ac.uk/ena/data/view/X05653 EchoBASE EB0795 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0795 EcoGene EG10802 http://www.ecogene.org/geneInfo.php?eg_id=EG10802 EnsemblBacteria AAC74100 http://www.ensemblgenomes.org/id/AAC74100 EnsemblBacteria AAC74100 http://www.ensemblgenomes.org/id/AAC74100 EnsemblBacteria BAA35793 http://www.ensemblgenomes.org/id/BAA35793 EnsemblBacteria BAA35793 http://www.ensemblgenomes.org/id/BAA35793 EnsemblBacteria BAA35793 http://www.ensemblgenomes.org/id/BAA35793 EnsemblBacteria b1015 http://www.ensemblgenomes.org/id/b1015 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0005298 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005298 GO_function GO:0031402 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031402 GO_process GO:0015824 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015824 GO_process GO:0015912 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015912 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 945602 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945602 HOGENOM HOG000282935 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000282935&db=HOGENOM6 InParanoid P07117 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P07117 IntAct P07117 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P07117* InterPro IPR001734 http://www.ebi.ac.uk/interpro/entry/IPR001734 InterPro IPR011851 http://www.ebi.ac.uk/interpro/entry/IPR011851 InterPro IPR018212 http://www.ebi.ac.uk/interpro/entry/IPR018212 KEGG_Gene ecj:JW1001 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1001 KEGG_Gene eco:b1015 http://www.genome.jp/dbget-bin/www_bget?eco:b1015 KEGG_Orthology KO:K11928 http://www.genome.jp/dbget-bin/www_bget?KO:K11928 OMA EYSTALW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EYSTALW PANTHER PTHR11819 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11819 PANTHER PTHR11819:SF148 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11819:SF148 PROSITE PS00456 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00456 PROSITE PS00457 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00457 PROSITE PS50283 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50283 PSORT swissprot:PUTP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PUTP_ECOLI PSORT-B swissprot:PUTP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PUTP_ECOLI PSORT2 swissprot:PUTP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PUTP_ECOLI Pfam PF00474 http://pfam.xfam.org/family/PF00474 Phobius swissprot:PUTP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PUTP_ECOLI PhylomeDB P07117 http://phylomedb.org/?seqid=P07117 ProteinModelPortal P07117 http://www.proteinmodelportal.org/query/uniprot/P07117 PubMed 1400239 http://www.ncbi.nlm.nih.gov/pubmed/1400239 PubMed 1567896 http://www.ncbi.nlm.nih.gov/pubmed/1567896 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17088549 http://www.ncbi.nlm.nih.gov/pubmed/17088549 PubMed 3053649 http://www.ncbi.nlm.nih.gov/pubmed/3053649 PubMed 3053687 http://www.ncbi.nlm.nih.gov/pubmed/3053687 PubMed 3302614 http://www.ncbi.nlm.nih.gov/pubmed/3302614 PubMed 3325781 http://www.ncbi.nlm.nih.gov/pubmed/3325781 PubMed 8119910 http://www.ncbi.nlm.nih.gov/pubmed/8119910 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415535 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415535 RefSeq WP_001018479 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001018479 STRING 511145.b1015 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1015&targetmode=cogs STRING COG0591 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0591&targetmode=cogs TCDB 2.A.21.2 http://www.tcdb.org/search/result.php?tc=2.A.21.2 TIGRFAMs TIGR00813 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00813 TIGRFAMs TIGR02121 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02121 UniProtKB PUTP_ECOLI http://www.uniprot.org/uniprot/PUTP_ECOLI UniProtKB-AC P07117 http://www.uniprot.org/uniprot/P07117 charge swissprot:PUTP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PUTP_ECOLI eggNOG COG0591 http://eggnogapi.embl.de/nog_data/html/tree/COG0591 eggNOG ENOG4105CK7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CK7 epestfind swissprot:PUTP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PUTP_ECOLI garnier swissprot:PUTP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PUTP_ECOLI helixturnhelix swissprot:PUTP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PUTP_ECOLI hmoment swissprot:PUTP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PUTP_ECOLI iep swissprot:PUTP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PUTP_ECOLI inforesidue swissprot:PUTP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PUTP_ECOLI octanol swissprot:PUTP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PUTP_ECOLI pepcoil swissprot:PUTP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PUTP_ECOLI pepdigest swissprot:PUTP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PUTP_ECOLI pepinfo swissprot:PUTP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PUTP_ECOLI pepnet swissprot:PUTP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PUTP_ECOLI pepstats swissprot:PUTP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PUTP_ECOLI pepwheel swissprot:PUTP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PUTP_ECOLI pepwindow swissprot:PUTP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PUTP_ECOLI sigcleave swissprot:PUTP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PUTP_ECOLI ## Database ID URL or Descriptions # AltName ILVE_ECOLI Transaminase B # BRENDA 2.6.1.42 2026 # BioGrid 4261272 66 # CATALYTIC ACTIVITY ILVE_ECOLI L-isoleucine + 2-oxoglutarate = (S)-3-methyl- 2-oxopentanoate + L-glutamate. # CATALYTIC ACTIVITY ILVE_ECOLI L-leucine + 2-oxoglutarate = 4-methyl-2- oxopentanoate + L-glutamate. # CATALYTIC ACTIVITY ILVE_ECOLI L-valine + 2-oxoglutarate = 3-methyl-2- oxobutanoate + L-glutamate. # CDD cd01557 BCAT_beta_family # COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI 597326; # EcoGene EG10497 ilvE # FUNCTION ILVE_ECOLI Acts on leucine, isoleucine and valine. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004084 branched-chain-amino-acid transaminase activity; IDA:EcoCyc. # GO_function GO:0030170 pyridoxal phosphate binding; IBA:GO_Central. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0052654 L-leucine transaminase activity; IEA:UniProtKB-EC. # GO_function GO:0052655 L-valine transaminase activity; IEA:UniProtKB-EC. # GO_function GO:0052656 L-isoleucine transaminase activity; IEA:UniProtKB-EC. # GO_process GO:0006532 aspartate biosynthetic process; IGI:EcoliWiki. # GO_process GO:0009097 isoleucine biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0009098 leucine biosynthetic process; IDA:EcoCyc. # GO_process GO:0009099 valine biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # InterPro IPR001544 Aminotrans_IV # InterPro IPR005785 B_amino_transI # InterPro IPR018300 Aminotrans_IV_CS # InterPro IPR033939 BCAT_family # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01007 Amino acid related enzymes # KEGG_Pathway ko00280 Valine, leucine and isoleucine degradation # KEGG_Pathway ko00290 Valine, leucine and isoleucine biosynthesis # KEGG_Pathway ko00770 Pantothenate and CoA biosynthesis # Organism ILVE_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11825 PTHR11825 # PATHWAY Amino-acid biosynthesis; L-isoleucine biosynthesis; L- isoleucine from 2-oxobutanoate step 4/4. # PATHWAY Amino-acid biosynthesis; L-leucine biosynthesis; L- leucine from 3-methyl-2-oxobutanoate step 4/4. # PATHWAY Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate step 4/4. # PATRIC 32123035 VBIEscCol129921_3887 # PDB 1A3G X-ray; 2.50 A; A/B/C=2-309 # PDB 1I1K X-ray; 2.10 A; A/B/C=1-309 # PDB 1I1L X-ray; 2.40 A; A/B/C=1-309 # PDB 1I1M X-ray; 2.40 A; A/B/C=1-309 # PDB 1IYD X-ray; 2.15 A; A/B/C=1-309 # PDB 1IYE X-ray; 1.82 A; A/B/C=1-309 # PIR E65180 XNECV # PROSITE PS00770 AA_TRANSFER_CLASS_4 # Pfam PF01063 Aminotran_4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ILVE_ECOLI Branched-chain-amino-acid aminotransferase # RefSeq WP_000208520 NZ_LN832404.1 # RefSeq YP_026247 NC_000913.3 # SIMILARITY Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. {ECO 0000305}. # SUBUNIT ILVE_ECOLI Homohexamer. # SUPFAM SSF56752 SSF56752 # TIGRFAMs TIGR01122 ilvE_I # UniPathway UPA00047 UER00058 # UniPathway UPA00048 UER00073 # UniPathway UPA00049 UER00062 # eggNOG COG0115 LUCA # eggNOG ENOG4105CM2 Bacteria BLAST swissprot:ILVE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ILVE_ECOLI BioCyc ECOL316407:JW5606-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5606-MONOMER BioCyc EcoCyc:BRANCHED-CHAINAMINOTRANSFER-MONOMER http://biocyc.org/getid?id=EcoCyc:BRANCHED-CHAINAMINOTRANSFER-MONOMER BioCyc MetaCyc:BRANCHED-CHAINAMINOTRANSFER-MONOMER http://biocyc.org/getid?id=MetaCyc:BRANCHED-CHAINAMINOTRANSFER-MONOMER COG COG0115 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0115 DIP DIP-10022N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10022N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0022-2836(92)90460-2 http://dx.doi.org/10.1016/0022-2836(92)90460-2 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/15.5.2137 http://dx.doi.org/10.1093/nar/15.5.2137 DOI 10.1093/nar/7.8.2289 http://dx.doi.org/10.1093/nar/7.8.2289 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1093/oxfordjournals.jbchem.a021633 http://dx.doi.org/10.1093/oxfordjournals.jbchem.a021633 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.6.1.42 http://www.genome.jp/dbget-bin/www_bget?EC:2.6.1.42 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M10313 http://www.ebi.ac.uk/ena/data/view/M10313 EMBL M32253 http://www.ebi.ac.uk/ena/data/view/M32253 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00290 http://www.ebi.ac.uk/ena/data/view/V00290 EMBL X02413 http://www.ebi.ac.uk/ena/data/view/X02413 EMBL X04890 http://www.ebi.ac.uk/ena/data/view/X04890 ENZYME 2.6.1.42 http://enzyme.expasy.org/EC/2.6.1.42 EchoBASE EB0492 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0492 EcoGene EG10497 http://www.ecogene.org/geneInfo.php?eg_id=EG10497 EnsemblBacteria AAT48207 http://www.ensemblgenomes.org/id/AAT48207 EnsemblBacteria AAT48207 http://www.ensemblgenomes.org/id/AAT48207 EnsemblBacteria BAE77527 http://www.ensemblgenomes.org/id/BAE77527 EnsemblBacteria BAE77527 http://www.ensemblgenomes.org/id/BAE77527 EnsemblBacteria BAE77527 http://www.ensemblgenomes.org/id/BAE77527 EnsemblBacteria b3770 http://www.ensemblgenomes.org/id/b3770 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004084 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004084 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0052654 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052654 GO_function GO:0052655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052655 GO_function GO:0052656 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052656 GO_process GO:0006532 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006532 GO_process GO:0009097 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009097 GO_process GO:0009098 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009098 GO_process GO:0009099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009099 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 948278 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948278 HOGENOM HOG000276706 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276706&db=HOGENOM6 InParanoid P0AB80 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AB80 IntEnz 2.6.1.42 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.6.1.42 InterPro IPR001544 http://www.ebi.ac.uk/interpro/entry/IPR001544 InterPro IPR005785 http://www.ebi.ac.uk/interpro/entry/IPR005785 InterPro IPR018300 http://www.ebi.ac.uk/interpro/entry/IPR018300 InterPro IPR033939 http://www.ebi.ac.uk/interpro/entry/IPR033939 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Gene ecj:JW5606 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5606 KEGG_Gene eco:b3770 http://www.genome.jp/dbget-bin/www_bget?eco:b3770 KEGG_Orthology KO:K00826 http://www.genome.jp/dbget-bin/www_bget?KO:K00826 KEGG_Pathway ko00280 http://www.genome.jp/kegg-bin/show_pathway?ko00280 KEGG_Pathway ko00290 http://www.genome.jp/kegg-bin/show_pathway?ko00290 KEGG_Pathway ko00770 http://www.genome.jp/kegg-bin/show_pathway?ko00770 KEGG_Reaction rn:R01090 http://www.genome.jp/dbget-bin/www_bget?rn:R01090 KEGG_Reaction rn:R01214 http://www.genome.jp/dbget-bin/www_bget?rn:R01214 KEGG_Reaction rn:R02199 http://www.genome.jp/dbget-bin/www_bget?rn:R02199 OMA AMISSWN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AMISSWN PANTHER PTHR11825 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11825 PDB 1A3G http://www.ebi.ac.uk/pdbe-srv/view/entry/1A3G PDB 1I1K http://www.ebi.ac.uk/pdbe-srv/view/entry/1I1K PDB 1I1L http://www.ebi.ac.uk/pdbe-srv/view/entry/1I1L PDB 1I1M http://www.ebi.ac.uk/pdbe-srv/view/entry/1I1M PDB 1IYD http://www.ebi.ac.uk/pdbe-srv/view/entry/1IYD PDB 1IYE http://www.ebi.ac.uk/pdbe-srv/view/entry/1IYE PDBsum 1A3G http://www.ebi.ac.uk/pdbsum/1A3G PDBsum 1I1K http://www.ebi.ac.uk/pdbsum/1I1K PDBsum 1I1L http://www.ebi.ac.uk/pdbsum/1I1L PDBsum 1I1M http://www.ebi.ac.uk/pdbsum/1I1M PDBsum 1IYD http://www.ebi.ac.uk/pdbsum/1IYD PDBsum 1IYE http://www.ebi.ac.uk/pdbsum/1IYE PROSITE PS00770 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00770 PSORT swissprot:ILVE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ILVE_ECOLI PSORT-B swissprot:ILVE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ILVE_ECOLI PSORT2 swissprot:ILVE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ILVE_ECOLI Pfam PF01063 http://pfam.xfam.org/family/PF01063 Phobius swissprot:ILVE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ILVE_ECOLI PhylomeDB P0AB80 http://phylomedb.org/?seqid=P0AB80 ProteinModelPortal P0AB80 http://www.proteinmodelportal.org/query/uniprot/P0AB80 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 1569580 http://www.ncbi.nlm.nih.gov/pubmed/1569580 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3069843 http://www.ncbi.nlm.nih.gov/pubmed/3069843 PubMed 3550695 http://www.ncbi.nlm.nih.gov/pubmed/3550695 PubMed 3897211 http://www.ncbi.nlm.nih.gov/pubmed/3897211 PubMed 392469 http://www.ncbi.nlm.nih.gov/pubmed/392469 PubMed 9163511 http://www.ncbi.nlm.nih.gov/pubmed/9163511 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq WP_000208520 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000208520 RefSeq YP_026247 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026247 SMR P0AB80 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AB80 STRING 511145.b3770 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3770&targetmode=cogs STRING COG0115 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0115&targetmode=cogs SUPFAM SSF56752 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56752 SWISS-2DPAGE P0AB80 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AB80 TIGRFAMs TIGR01122 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01122 UniProtKB ILVE_ECOLI http://www.uniprot.org/uniprot/ILVE_ECOLI UniProtKB-AC P0AB80 http://www.uniprot.org/uniprot/P0AB80 charge swissprot:ILVE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ILVE_ECOLI eggNOG COG0115 http://eggnogapi.embl.de/nog_data/html/tree/COG0115 eggNOG ENOG4105CM2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CM2 epestfind swissprot:ILVE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ILVE_ECOLI garnier swissprot:ILVE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ILVE_ECOLI helixturnhelix swissprot:ILVE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ILVE_ECOLI hmoment swissprot:ILVE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ILVE_ECOLI iep swissprot:ILVE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ILVE_ECOLI inforesidue swissprot:ILVE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ILVE_ECOLI octanol swissprot:ILVE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ILVE_ECOLI pepcoil swissprot:ILVE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ILVE_ECOLI pepdigest swissprot:ILVE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ILVE_ECOLI pepinfo swissprot:ILVE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ILVE_ECOLI pepnet swissprot:ILVE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ILVE_ECOLI pepstats swissprot:ILVE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ILVE_ECOLI pepwheel swissprot:ILVE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ILVE_ECOLI pepwindow swissprot:ILVE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ILVE_ECOLI sigcleave swissprot:ILVE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ILVE_ECOLI ## Database ID URL or Descriptions # AltName CCMC_ECOLI Cytochrome c-type biogenesis protein CcmC # BioGrid 4263174 20 # EcoGene EG12057 ccmC # FUNCTION CCMC_ECOLI Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; ISM:EcoCyc. # GO_function GO:0015232 heme transporter activity; IEA:InterPro. # GO_function GO:0020037 heme binding; IEA:InterPro. # GO_process GO:0017004 cytochrome complex assembly; IEA:UniProtKB-KW. # GO_process GO:0055114 oxidation-reduction process; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0008150 biological_process # INTERACTION CCMC_ECOLI P0ABM5 ccmD; NbExp=4; IntAct=EBI-2123469, EBI-3894922; P69490 ccmE; NbExp=6; IntAct=EBI-2123469, EBI-1128007; # IntAct P0ABM1 4 # InterPro IPR002541 Cyt_c_assembly # InterPro IPR003557 Cyt_c_biogenesis_CcmC # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00259 Heme transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism CCMC_ECOLI Escherichia coli (strain K12) # PATRIC 32119757 VBIEscCol129921_2288 # PIR E64989 E64989 # PRINTS PR01386 CCMCBIOGNSIS # Pfam PF01578 Cytochrom_C_asm # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CCMC_ECOLI Heme exporter protein C # RefSeq NP_416703 NC_000913.3 # RefSeq WP_001295447 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA16391.1; Type=Frameshift; Positions=156; Evidence={ECO 0000305}; # SIMILARITY Belongs to the CcmC/CycZ/HelC family. {ECO 0000305}. # SUBCELLULAR LOCATION CCMC_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 9.B.14.2 the putative heme handling protein (hhp) family # TIGRFAMs TIGR01191 ccmC # eggNOG COG0755 LUCA # eggNOG ENOG41060IM Bacteria BLAST swissprot:CCMC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CCMC_ECOLI BioCyc ECOL316407:JW2187-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2187-MONOMER BioCyc EcoCyc:CCMC-MONOMER http://biocyc.org/getid?id=EcoCyc:CCMC-MONOMER BioCyc MetaCyc:CCMC-MONOMER http://biocyc.org/getid?id=MetaCyc:CCMC-MONOMER COG COG0755 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0755 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00008 http://www.ebi.ac.uk/ena/data/view/U00008 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1987 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1987 EcoGene EG12057 http://www.ecogene.org/geneInfo.php?eg_id=EG12057 EnsemblBacteria AAC75259 http://www.ensemblgenomes.org/id/AAC75259 EnsemblBacteria AAC75259 http://www.ensemblgenomes.org/id/AAC75259 EnsemblBacteria BAE76662 http://www.ensemblgenomes.org/id/BAE76662 EnsemblBacteria BAE76662 http://www.ensemblgenomes.org/id/BAE76662 EnsemblBacteria BAE76662 http://www.ensemblgenomes.org/id/BAE76662 EnsemblBacteria b2199 http://www.ensemblgenomes.org/id/b2199 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015232 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015232 GO_function GO:0020037 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0020037 GO_process GO:0017004 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017004 GO_process GO:0055114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 946703 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946703 HOGENOM HOG000274637 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000274637&db=HOGENOM6 InParanoid P0ABM1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABM1 IntAct P0ABM1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABM1* InterPro IPR002541 http://www.ebi.ac.uk/interpro/entry/IPR002541 InterPro IPR003557 http://www.ebi.ac.uk/interpro/entry/IPR003557 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2187 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2187 KEGG_Gene eco:b2199 http://www.genome.jp/dbget-bin/www_bget?eco:b2199 KEGG_Orthology KO:K02195 http://www.genome.jp/dbget-bin/www_bget?KO:K02195 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 MINT MINT-1503327 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1503327 OMA PSIATPM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PSIATPM PRINTS PR01386 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01386 PSORT swissprot:CCMC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CCMC_ECOLI PSORT-B swissprot:CCMC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CCMC_ECOLI PSORT2 swissprot:CCMC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CCMC_ECOLI Pfam PF01578 http://pfam.xfam.org/family/PF01578 Phobius swissprot:CCMC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CCMC_ECOLI PhylomeDB P0ABM1 http://phylomedb.org/?seqid=P0ABM1 ProteinModelPortal P0ABM1 http://www.proteinmodelportal.org/query/uniprot/P0ABM1 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7635817 http://www.ncbi.nlm.nih.gov/pubmed/7635817 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416703 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416703 RefSeq WP_001295447 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295447 STRING 511145.b2199 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2199&targetmode=cogs STRING COG0755 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0755&targetmode=cogs TCDB 9.B.14.2 http://www.tcdb.org/search/result.php?tc=9.B.14.2 TIGRFAMs TIGR01191 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01191 UniProtKB CCMC_ECOLI http://www.uniprot.org/uniprot/CCMC_ECOLI UniProtKB-AC P0ABM1 http://www.uniprot.org/uniprot/P0ABM1 charge swissprot:CCMC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CCMC_ECOLI eggNOG COG0755 http://eggnogapi.embl.de/nog_data/html/tree/COG0755 eggNOG ENOG41060IM http://eggnogapi.embl.de/nog_data/html/tree/ENOG41060IM epestfind swissprot:CCMC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CCMC_ECOLI garnier swissprot:CCMC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CCMC_ECOLI helixturnhelix swissprot:CCMC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CCMC_ECOLI hmoment swissprot:CCMC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CCMC_ECOLI iep swissprot:CCMC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CCMC_ECOLI inforesidue swissprot:CCMC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CCMC_ECOLI octanol swissprot:CCMC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CCMC_ECOLI pepcoil swissprot:CCMC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CCMC_ECOLI pepdigest swissprot:CCMC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CCMC_ECOLI pepinfo swissprot:CCMC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CCMC_ECOLI pepnet swissprot:CCMC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CCMC_ECOLI pepstats swissprot:CCMC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CCMC_ECOLI pepwheel swissprot:CCMC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CCMC_ECOLI pepwindow swissprot:CCMC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CCMC_ECOLI sigcleave swissprot:CCMC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CCMC_ECOLI ## Database ID URL or Descriptions # AltName MURR_ECOLI MurPQ operon repressor # BioGrid 4263047 28 # DISRUPTION PHENOTYPE Cells lacking this gene show an abolition of the extensive lag phase observed when grown on MurNAc and a 20- fold enhancement of murQ transcription. {ECO:0000269|PubMed 18723630}. # EcoGene EG14161 murR # FUNCTION MURR_ECOLI Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator. Also represses its own transcription. {ECO 0000269|PubMed 18723630}. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IDA:EcoCyc. # GO_function GO:0030246 carbohydrate binding; IEA:UniProtKB-HAMAP. # GO_process GO:0005975 carbohydrate metabolic process; IEA:UniProtKB-HAMAP. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-HAMAP. # GO_process GO:0043470 regulation of carbohydrate catabolic process; IEA:UniProtKB-HAMAP. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0097173 N-acetylmuramic acid catabolic process; IEA:UniProtKB-UniPathway. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.10.10 -; 1. # HAMAP MF_02108 HTH_type_MurR # INDUCTION Repressed by itself and by the cAMP receptor protein crp. {ECO:0000269|PubMed 18723630}. # IntAct P77245 12 # InterPro IPR000281 HTH_RpiR # InterPro IPR001347 SIS # InterPro IPR009057 Homeodomain-like # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR022821 Tscrpt_reg_HTH_MurR # KEGG_Brite ko03000 Transcription factors # MISCELLANEOUS MURR_ECOLI Neither GlcNAc-6-P, GlcNAc, anhydroMurNAc, MurNAc, nor muramyl dipeptide have an effect on MurR binding to the operator site. # Organism MURR_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-sugar metabolism; N-acetylmuramate degradation [regulation]. {ECO:0000269|PubMed 18723630}. # PATRIC 32120239 VBIEscCol129921_2522 # PIR B65017 B65017 # PROSITE PS51071 HTH_RPIR # PROSITE PS51464 SIS # Pfam PF01380 SIS # Pfam PF01418 HTH_6 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MURR_ECOLI HTH-type transcriptional regulator MurR # RefSeq NP_416922 NC_000913.3 # RefSeq WP_000966470 NZ_LN832404.1 # SIMILARITY Contains 1 HTH rpiR-type DNA-binding domain. {ECO 0000305}. # SIMILARITY Contains 1 SIS domain. {ECO 0000305}. # SUBUNIT Homotetramer. {ECO:0000305|PubMed 18723630}. # SUPFAM SSF46689 SSF46689 # eggNOG COG1737 LUCA # eggNOG ENOG4108PSC Bacteria BLAST swissprot:MURR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MURR_ECOLI BioCyc ECOL316407:JW2420-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2420-MONOMER BioCyc EcoCyc:G7262-MONOMER http://biocyc.org/getid?id=EcoCyc:G7262-MONOMER COG COG1737 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1737 DIP DIP-12018N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12018N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00642-08 http://dx.doi.org/10.1128/JB.00642-08 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3913 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3913 EcoGene EG14161 http://www.ecogene.org/geneInfo.php?eg_id=EG14161 EnsemblBacteria AAC75480 http://www.ensemblgenomes.org/id/AAC75480 EnsemblBacteria AAC75480 http://www.ensemblgenomes.org/id/AAC75480 EnsemblBacteria BAA16310 http://www.ensemblgenomes.org/id/BAA16310 EnsemblBacteria BAA16310 http://www.ensemblgenomes.org/id/BAA16310 EnsemblBacteria BAA16310 http://www.ensemblgenomes.org/id/BAA16310 EnsemblBacteria b2427 http://www.ensemblgenomes.org/id/b2427 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0030246 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030246 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0043470 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043470 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GO_process GO:0097173 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097173 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 946568 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946568 HAMAP MF_02108 http://hamap.expasy.org/unirule/MF_02108 HOGENOM HOG000027157 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000027157&db=HOGENOM6 InParanoid P77245 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77245 IntAct P77245 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77245* InterPro IPR000281 http://www.ebi.ac.uk/interpro/entry/IPR000281 InterPro IPR001347 http://www.ebi.ac.uk/interpro/entry/IPR001347 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR022821 http://www.ebi.ac.uk/interpro/entry/IPR022821 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW2420 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2420 KEGG_Gene eco:b2427 http://www.genome.jp/dbget-bin/www_bget?eco:b2427 KEGG_Orthology KO:K15835 http://www.genome.jp/dbget-bin/www_bget?KO:K15835 OMA RFRTEAM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RFRTEAM PROSITE PS51071 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51071 PROSITE PS51464 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51464 PSORT swissprot:MURR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MURR_ECOLI PSORT-B swissprot:MURR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MURR_ECOLI PSORT2 swissprot:MURR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MURR_ECOLI Pfam PF01380 http://pfam.xfam.org/family/PF01380 Pfam PF01418 http://pfam.xfam.org/family/PF01418 Phobius swissprot:MURR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MURR_ECOLI PhylomeDB P77245 http://phylomedb.org/?seqid=P77245 ProteinModelPortal P77245 http://www.proteinmodelportal.org/query/uniprot/P77245 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723630 http://www.ncbi.nlm.nih.gov/pubmed/18723630 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416922 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416922 RefSeq WP_000966470 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000966470 SMR P77245 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77245 STRING 511145.b2427 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2427&targetmode=cogs STRING COG1737 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1737&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 UniProtKB MURR_ECOLI http://www.uniprot.org/uniprot/MURR_ECOLI UniProtKB-AC P77245 http://www.uniprot.org/uniprot/P77245 charge swissprot:MURR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MURR_ECOLI eggNOG COG1737 http://eggnogapi.embl.de/nog_data/html/tree/COG1737 eggNOG ENOG4108PSC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108PSC epestfind swissprot:MURR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MURR_ECOLI garnier swissprot:MURR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MURR_ECOLI helixturnhelix swissprot:MURR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MURR_ECOLI hmoment swissprot:MURR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MURR_ECOLI iep swissprot:MURR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MURR_ECOLI inforesidue swissprot:MURR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MURR_ECOLI octanol swissprot:MURR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MURR_ECOLI pepcoil swissprot:MURR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MURR_ECOLI pepdigest swissprot:MURR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MURR_ECOLI pepinfo swissprot:MURR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MURR_ECOLI pepnet swissprot:MURR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MURR_ECOLI pepstats swissprot:MURR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MURR_ECOLI pepwheel swissprot:MURR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MURR_ECOLI pepwindow swissprot:MURR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MURR_ECOLI sigcleave swissprot:MURR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MURR_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES TRKG_ECOLI Kinetic parameters KM=1 mM for K(+) {ECO 0000269|PubMed 7896723}; KM=0.4 mM for Rb(+) {ECO 0000269|PubMed 7896723}; Vmax=300 umol/min/g enzyme with K(+) as substrate {ECO 0000269|PubMed 7896723}; Vmax=17 umol/min/g enzyme with Rb(+) as substrate {ECO 0000269|PubMed 7896723}; # BioGrid 4260161 11 # EcoGene EG11020 trkG # FUNCTION TRKG_ECOLI Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA and requires TrkE for transport activity. Can transport potassium and rubidium. {ECO 0000269|PubMed 2022616, ECO 0000269|PubMed 2674131, ECO 0000269|PubMed 7896723}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_function GO:0005267 potassium channel activity; ISS:UniProtKB. # GO_function GO:0015388 potassium uptake transmembrane transporter activity; IMP:CACAO. # GO_function GO:0022820 potassium ion symporter activity; IEA:InterPro. # GO_function GO:0030955 potassium ion binding; ISS:UniProtKB. # GO_process GO:0071805 potassium ion transmembrane transport; ISS:UniProtKB. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0055085 transmembrane transport # InterPro IPR003445 Cat_transpt # InterPro IPR004772 TrkH # Organism TRKG_ECOLI Escherichia coli (strain K12) # PATRIC 32118004 VBIEscCol129921_1422 # PIR A39408 A39408 # PIRSF PIRSF006247 TrkH # Pfam PF02386 TrkH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TRKG_ECOLI Trk system potassium uptake protein TrkG # RefSeq NP_415881 NC_000913.3 # RefSeq WP_001097895 NZ_CP014272.1 # SIMILARITY Belongs to the TrkH potassium transport family. {ECO 0000305}. # SUBCELLULAR LOCATION TRKG_ECOLI Cell inner membrane {ECO 0000269|PubMed 2022616}; Multi-pass membrane protein {ECO 0000269|PubMed 2022616}. # TCDB 2.A.38.1 the k(+) transporter (trk) family # TIGRFAMs TIGR00933 2a38 # eggNOG COG0168 LUCA # eggNOG ENOG4105D37 Bacteria BLAST swissprot:TRKG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRKG_ECOLI BioCyc ECOL316407:JW1358-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1358-MONOMER BioCyc EcoCyc:TRKG-MONOMER http://biocyc.org/getid?id=EcoCyc:TRKG-MONOMER BioCyc MetaCyc:TRKG-MONOMER http://biocyc.org/getid?id=MetaCyc:TRKG-MONOMER DIP DIP-11029N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11029N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X56783 http://www.ebi.ac.uk/ena/data/view/X56783 EchoBASE EB1013 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1013 EcoGene EG11020 http://www.ecogene.org/geneInfo.php?eg_id=EG11020 EnsemblBacteria AAC74445 http://www.ensemblgenomes.org/id/AAC74445 EnsemblBacteria AAC74445 http://www.ensemblgenomes.org/id/AAC74445 EnsemblBacteria BAA14960 http://www.ensemblgenomes.org/id/BAA14960 EnsemblBacteria BAA14960 http://www.ensemblgenomes.org/id/BAA14960 EnsemblBacteria BAA14960 http://www.ensemblgenomes.org/id/BAA14960 EnsemblBacteria b1363 http://www.ensemblgenomes.org/id/b1363 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0005267 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005267 GO_function GO:0015388 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015388 GO_function GO:0022820 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022820 GO_function GO:0030955 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030955 GO_process GO:0071805 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 945932 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945932 HOGENOM HOG000225541 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000225541&db=HOGENOM6 InParanoid P23849 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23849 InterPro IPR003445 http://www.ebi.ac.uk/interpro/entry/IPR003445 InterPro IPR004772 http://www.ebi.ac.uk/interpro/entry/IPR004772 KEGG_Gene ecj:JW1358 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1358 KEGG_Gene eco:b1363 http://www.genome.jp/dbget-bin/www_bget?eco:b1363 OMA ISMTIMI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ISMTIMI PSORT swissprot:TRKG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRKG_ECOLI PSORT-B swissprot:TRKG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRKG_ECOLI PSORT2 swissprot:TRKG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRKG_ECOLI Pfam PF02386 http://pfam.xfam.org/family/PF02386 Phobius swissprot:TRKG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRKG_ECOLI PhylomeDB P23849 http://phylomedb.org/?seqid=P23849 ProteinModelPortal P23849 http://www.proteinmodelportal.org/query/uniprot/P23849 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2022616 http://www.ncbi.nlm.nih.gov/pubmed/2022616 PubMed 2674131 http://www.ncbi.nlm.nih.gov/pubmed/2674131 PubMed 7896723 http://www.ncbi.nlm.nih.gov/pubmed/7896723 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415881 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415881 RefSeq WP_001097895 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001097895 STRING 511145.b1363 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1363&targetmode=cogs TCDB 2.A.38.1 http://www.tcdb.org/search/result.php?tc=2.A.38.1 TIGRFAMs TIGR00933 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00933 UniProtKB TRKG_ECOLI http://www.uniprot.org/uniprot/TRKG_ECOLI UniProtKB-AC P23849 http://www.uniprot.org/uniprot/P23849 charge swissprot:TRKG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRKG_ECOLI eggNOG COG0168 http://eggnogapi.embl.de/nog_data/html/tree/COG0168 eggNOG ENOG4105D37 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D37 epestfind swissprot:TRKG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRKG_ECOLI garnier swissprot:TRKG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRKG_ECOLI helixturnhelix swissprot:TRKG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRKG_ECOLI hmoment swissprot:TRKG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRKG_ECOLI iep swissprot:TRKG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRKG_ECOLI inforesidue swissprot:TRKG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRKG_ECOLI octanol swissprot:TRKG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRKG_ECOLI pepcoil swissprot:TRKG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRKG_ECOLI pepdigest swissprot:TRKG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRKG_ECOLI pepinfo swissprot:TRKG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRKG_ECOLI pepnet swissprot:TRKG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRKG_ECOLI pepstats swissprot:TRKG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRKG_ECOLI pepwheel swissprot:TRKG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRKG_ECOLI pepwindow swissprot:TRKG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRKG_ECOLI sigcleave swissprot:TRKG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRKG_ECOLI ## Database ID URL or Descriptions # EcoGene EG14404 ldrB # FUNCTION LDRB_ECOLI Toxic peptide whose overexpression causes rapid cell killing and nucleoid condensation of the host cell. {ECO 0000250}. # INDUCTION A type I toxin antitoxin (TA) system, where expression of the proteinaceous toxin is controlled by an antisense sRNA, in this case rdlB. Only a few of these TA systems have been mechanistically characterized; the mechanisms used to control expression of the toxin gene are not necessarily the same (Probable). {ECO 0000305}. # InterPro IPR025253 Toxin_Ldr # Organism LDRB_ECOLI Escherichia coli (strain K12) # PATRIC 32117686 VBIEscCol129921_1265 # Pfam PF13940 Ldr_toxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LDRB_ECOLI Small toxic polypeptide LdrB # RefSeq YP_025298 NC_000913.3 # SIMILARITY Belongs to the toxic peptide ldr family. {ECO 0000305}. BLAST swissprot:LDRB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LDRB_ECOLI BioCyc ECOL316407:JW5958-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5958-MONOMER BioCyc EcoCyc:MONOMER0-1602 http://biocyc.org/getid?id=EcoCyc:MONOMER0-1602 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2002.03042.x http://dx.doi.org/10.1046/j.1365-2958.2002.03042.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14404 http://www.ecogene.org/geneInfo.php?eg_id=EG14404 EnsemblBacteria AAT48127 http://www.ensemblgenomes.org/id/AAT48127 EnsemblBacteria AAT48127 http://www.ensemblgenomes.org/id/AAT48127 EnsemblBacteria BAE76393 http://www.ensemblgenomes.org/id/BAE76393 EnsemblBacteria BAE76393 http://www.ensemblgenomes.org/id/BAE76393 EnsemblBacteria BAE76393 http://www.ensemblgenomes.org/id/BAE76393 EnsemblBacteria b4421 http://www.ensemblgenomes.org/id/b4421 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 2847735 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2847735 HOGENOM HOG000125979 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125979&db=HOGENOM6 InterPro IPR025253 http://www.ebi.ac.uk/interpro/entry/IPR025253 KEGG_Gene ecj:JW5958 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5958 KEGG_Gene eco:b4421 http://www.genome.jp/dbget-bin/www_bget?eco:b4421 PSORT swissprot:LDRB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LDRB_ECOLI PSORT-B swissprot:LDRB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LDRB_ECOLI PSORT2 swissprot:LDRB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LDRB_ECOLI Pfam PF13940 http://pfam.xfam.org/family/PF13940 Phobius swissprot:LDRB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LDRB_ECOLI PhylomeDB Q6BF87 http://phylomedb.org/?seqid=Q6BF87 PubMed 12123448 http://www.ncbi.nlm.nih.gov/pubmed/12123448 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq YP_025298 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_025298 UniProtKB LDRB_ECOLI http://www.uniprot.org/uniprot/LDRB_ECOLI UniProtKB-AC Q6BF87 http://www.uniprot.org/uniprot/Q6BF87 charge swissprot:LDRB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LDRB_ECOLI epestfind swissprot:LDRB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LDRB_ECOLI garnier swissprot:LDRB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LDRB_ECOLI helixturnhelix swissprot:LDRB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LDRB_ECOLI hmoment swissprot:LDRB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LDRB_ECOLI iep swissprot:LDRB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LDRB_ECOLI inforesidue swissprot:LDRB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LDRB_ECOLI octanol swissprot:LDRB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LDRB_ECOLI pepcoil swissprot:LDRB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LDRB_ECOLI pepdigest swissprot:LDRB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LDRB_ECOLI pepinfo swissprot:LDRB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LDRB_ECOLI pepnet swissprot:LDRB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LDRB_ECOLI pepstats swissprot:LDRB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LDRB_ECOLI pepwheel swissprot:LDRB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LDRB_ECOLI pepwindow swissprot:LDRB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LDRB_ECOLI sigcleave swissprot:LDRB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LDRB_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES pH dependence Optimum pH is 6.2-8.0.; # BioGrid 4259757 7 # CATALYTIC ACTIVITY DCLZ_ECOLI L-lysine = cadaverine + CO(2). # CDD cd00615 Orn_deC_like # COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI 597326; # EcoGene EG13219 ldcC # FUNCTION DCLZ_ECOLI LDC is constitutively but weakly expressed under various conditions. # GO_component GO:0005737 cytoplasm; IEA:InterPro. # GO_function GO:0008923 lysine decarboxylase activity; IDA:EcoCyc. # GO_process GO:0006554 lysine catabolic process; IDA:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # Gene3D 3.40.640.10 -; 1. # Gene3D 3.90.100.10 -; 1. # Gene3D 3.90.1150.10 -; 1. # INTERACTION DCLZ_ECOLI P0A9H3 cadA; NbExp=3; IntAct=EBI-545944, EBI-545922; # IntAct P52095 5 # InterPro IPR000310 Orn/Lys/Arg_deCO2ase_major_dom # InterPro IPR005308 OKR_de-COase_N # InterPro IPR008286 Prn/Lys/Arg_de-COase_C # InterPro IPR011193 Orn/lys/arg_de-COase # InterPro IPR015421 PyrdxlP-dep_Trfase_major_sub1 # InterPro IPR015422 PyrdxlP-dep_Trfase_major_sub2 # InterPro IPR015424 PyrdxlP-dep_Trfase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00310 Lysine degradation # KEGG_Pathway ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis # Organism DCLZ_ECOLI Escherichia coli (strain K12) # PATRIC 32115483 VBIEscCol129921_0193 # PDB 5FKZ EM; 5.50 A; E=1-710 # PIR B64743 B64743 # PIRSF PIRSF009393 Orn_decarb # PROSITE PS00703 OKR_DC_1 # Pfam PF01276 OKR_DC_1 # Pfam PF03709 OKR_DC_1_N # Pfam PF03711 OKR_DC_1_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DCLZ_ECOLI Lysine decarboxylase, constitutive # RefSeq NP_414728 NC_000913.3 # RefSeq WP_001020973 NZ_LN832404.1 # SIMILARITY Belongs to the Orn/Lys/Arg decarboxylase class-I family. {ECO 0000305}. # SUBUNIT DCLZ_ECOLI Homodecamer. # SUPFAM SSF53383 SSF53383 # SUPFAM SSF55904 SSF55904 # eggNOG COG1982 LUCA # eggNOG ENOG4105CXN Bacteria BLAST swissprot:DCLZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DCLZ_ECOLI BioCyc ECOL316407:JW0181-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0181-MONOMER BioCyc EcoCyc:LDC2-MONOMER http://biocyc.org/getid?id=EcoCyc:LDC2-MONOMER BioCyc MetaCyc:LDC2-MONOMER http://biocyc.org/getid?id=MetaCyc:LDC2-MONOMER COG COG1982 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1982 DIP DIP-10086N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10086N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1998.00981.x http://dx.doi.org/10.1046/j.1365-2958.1998.00981.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1266/ggs.72.167 http://dx.doi.org/10.1266/ggs.72.167 EC_number EC:4.1.1.18 http://www.genome.jp/dbget-bin/www_bget?EC:4.1.1.18 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D49445 http://www.ebi.ac.uk/ena/data/view/D49445 EMBL D87518 http://www.ebi.ac.uk/ena/data/view/D87518 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EMBL Z50870 http://www.ebi.ac.uk/ena/data/view/Z50870 ENZYME 4.1.1.18 http://enzyme.expasy.org/EC/4.1.1.18 EchoBASE EB3010 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3010 EcoGene EG13219 http://www.ecogene.org/geneInfo.php?eg_id=EG13219 EnsemblBacteria AAC73297 http://www.ensemblgenomes.org/id/AAC73297 EnsemblBacteria AAC73297 http://www.ensemblgenomes.org/id/AAC73297 EnsemblBacteria BAA77861 http://www.ensemblgenomes.org/id/BAA77861 EnsemblBacteria BAA77861 http://www.ensemblgenomes.org/id/BAA77861 EnsemblBacteria BAA77861 http://www.ensemblgenomes.org/id/BAA77861 EnsemblBacteria b0186 http://www.ensemblgenomes.org/id/b0186 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0008923 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008923 GO_process GO:0006554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006554 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 3.40.640.10 http://www.cathdb.info/version/latest/superfamily/3.40.640.10 Gene3D 3.90.100.10 http://www.cathdb.info/version/latest/superfamily/3.90.100.10 Gene3D 3.90.1150.10 http://www.cathdb.info/version/latest/superfamily/3.90.1150.10 GeneID 944887 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944887 HOGENOM HOG000164394 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000164394&db=HOGENOM6 InParanoid P52095 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P52095 IntAct P52095 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P52095* IntEnz 4.1.1.18 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.1.18 InterPro IPR000310 http://www.ebi.ac.uk/interpro/entry/IPR000310 InterPro IPR005308 http://www.ebi.ac.uk/interpro/entry/IPR005308 InterPro IPR008286 http://www.ebi.ac.uk/interpro/entry/IPR008286 InterPro IPR011193 http://www.ebi.ac.uk/interpro/entry/IPR011193 InterPro IPR015421 http://www.ebi.ac.uk/interpro/entry/IPR015421 InterPro IPR015422 http://www.ebi.ac.uk/interpro/entry/IPR015422 InterPro IPR015424 http://www.ebi.ac.uk/interpro/entry/IPR015424 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0181 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0181 KEGG_Gene eco:b0186 http://www.genome.jp/dbget-bin/www_bget?eco:b0186 KEGG_Orthology KO:K01582 http://www.genome.jp/dbget-bin/www_bget?KO:K01582 KEGG_Pathway ko00310 http://www.genome.jp/kegg-bin/show_pathway?ko00310 KEGG_Pathway ko00960 http://www.genome.jp/kegg-bin/show_pathway?ko00960 KEGG_Reaction rn:R00462 http://www.genome.jp/dbget-bin/www_bget?rn:R00462 MINT MINT-1275881 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1275881 OMA FSIWQPP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FSIWQPP PDB 5FKZ http://www.ebi.ac.uk/pdbe-srv/view/entry/5FKZ PDBsum 5FKZ http://www.ebi.ac.uk/pdbsum/5FKZ PROSITE PS00703 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00703 PSORT swissprot:DCLZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DCLZ_ECOLI PSORT-B swissprot:DCLZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DCLZ_ECOLI PSORT2 swissprot:DCLZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DCLZ_ECOLI Pfam PF01276 http://pfam.xfam.org/family/PF01276 Pfam PF03709 http://pfam.xfam.org/family/PF03709 Pfam PF03711 http://pfam.xfam.org/family/PF03711 Phobius swissprot:DCLZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DCLZ_ECOLI PhylomeDB P52095 http://phylomedb.org/?seqid=P52095 ProteinModelPortal P52095 http://www.proteinmodelportal.org/query/uniprot/P52095 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9226257 http://www.ncbi.nlm.nih.gov/pubmed/9226257 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9339543 http://www.ncbi.nlm.nih.gov/pubmed/9339543 PubMed 9723924 http://www.ncbi.nlm.nih.gov/pubmed/9723924 RefSeq NP_414728 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414728 RefSeq WP_001020973 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001020973 SMR P52095 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P52095 STRING 511145.b0186 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0186&targetmode=cogs STRING COG1982 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1982&targetmode=cogs SUPFAM SSF53383 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53383 SUPFAM SSF55904 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55904 UniProtKB DCLZ_ECOLI http://www.uniprot.org/uniprot/DCLZ_ECOLI UniProtKB-AC P52095 http://www.uniprot.org/uniprot/P52095 charge swissprot:DCLZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DCLZ_ECOLI eggNOG COG1982 http://eggnogapi.embl.de/nog_data/html/tree/COG1982 eggNOG ENOG4105CXN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CXN epestfind swissprot:DCLZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DCLZ_ECOLI garnier swissprot:DCLZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DCLZ_ECOLI helixturnhelix swissprot:DCLZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DCLZ_ECOLI hmoment swissprot:DCLZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DCLZ_ECOLI iep swissprot:DCLZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DCLZ_ECOLI inforesidue swissprot:DCLZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DCLZ_ECOLI octanol swissprot:DCLZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DCLZ_ECOLI pepcoil swissprot:DCLZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DCLZ_ECOLI pepdigest swissprot:DCLZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DCLZ_ECOLI pepinfo swissprot:DCLZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DCLZ_ECOLI pepnet swissprot:DCLZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DCLZ_ECOLI pepstats swissprot:DCLZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DCLZ_ECOLI pepwheel swissprot:DCLZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DCLZ_ECOLI pepwindow swissprot:DCLZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DCLZ_ECOLI sigcleave swissprot:DCLZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DCLZ_ECOLI ## Database ID URL or Descriptions # BioGrid 4262507 16 # CATALYTIC ACTIVITY ATP + H(2)O + Ni(2+)(Out) = ADP + phosphate + Ni(2+)(In). {ECO:0000255|HAMAP-Rule MF_01711}. # EcoGene EG12078 nikD # FUNCTION NIKD_ECOLI Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system. {ECO 0000255|HAMAP-Rule MF_01711}. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IEA:UniProtKB-HAMAP. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0015413 nickel-transporting ATPase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0016151 nickel cation binding; IEA:InterPro. # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.300 -; 1. # IntAct P33593 11 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR014138 Nickel_NikD # InterPro IPR015857 ABC_transpr_NikD # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00440 Nickel transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism NIKD_ECOLI Escherichia coli (strain K12) # PATRIC 32122402 VBIEscCol129921_3578 # PIR S47698 S47698 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # PROSITE PS51247 NIKD # Pfam PF00005 ABC_tran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Nickel import ATP-binding protein NikD {ECO:0000255|HAMAP-Rule MF_01711} # RefSeq NP_417936 NC_000913.3 # RefSeq WP_001136229 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family. {ECO:0000255|HAMAP-Rule MF_01711}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|HAMAP- Rule MF_01711}. # SMART SM00382 AAA # SUBCELLULAR LOCATION NIKD_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01711}; Peripheral membrane protein {ECO 0000255|HAMAP- Rule MF_01711}. # SUBUNIT The complex is composed of two ATP-binding proteins (NikD and NikE), two transmembrane proteins (NikB and NikC) and a solute-binding protein (NikA). {ECO:0000255|HAMAP-Rule MF_01711}. # SUPFAM SSF52540 SSF52540 # TCDB 3.A.1.5 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR02770 nickel_nikD # eggNOG COG0444 LUCA # eggNOG ENOG4106665 Bacteria BLAST swissprot:NIKD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NIKD_ECOLI BioCyc ECOL316407:JW3444-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3444-MONOMER BioCyc EcoCyc:NIKD-MONOMER http://biocyc.org/getid?id=EcoCyc:NIKD-MONOMER BioCyc MetaCyc:NIKD-MONOMER http://biocyc.org/getid?id=MetaCyc:NIKD-MONOMER COG COG0444 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0444 DIP DIP-10343N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10343N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1111/j.1365-2958.1993.tb01247.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb01247.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.3.24 {ECO:0000255|HAMAP-Rule:MF_01711} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.24 {ECO:0000255|HAMAP-Rule:MF_01711} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X73143 http://www.ebi.ac.uk/ena/data/view/X73143 ENZYME 3.6.3.24 {ECO:0000255|HAMAP-Rule:MF_01711} http://enzyme.expasy.org/EC/3.6.3.24 {ECO:0000255|HAMAP-Rule:MF_01711} EchoBASE EB2003 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2003 EcoGene EG12078 http://www.ecogene.org/geneInfo.php?eg_id=EG12078 EnsemblBacteria AAC76504 http://www.ensemblgenomes.org/id/AAC76504 EnsemblBacteria AAC76504 http://www.ensemblgenomes.org/id/AAC76504 EnsemblBacteria BAE77814 http://www.ensemblgenomes.org/id/BAE77814 EnsemblBacteria BAE77814 http://www.ensemblgenomes.org/id/BAE77814 EnsemblBacteria BAE77814 http://www.ensemblgenomes.org/id/BAE77814 EnsemblBacteria b3479 http://www.ensemblgenomes.org/id/b3479 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0015413 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015413 GO_function GO:0016151 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016151 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947989 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947989 InParanoid P33593 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33593 IntAct P33593 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33593* IntEnz 3.6.3.24 {ECO:0000255|HAMAP-Rule:MF_01711} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.24 {ECO:0000255|HAMAP-Rule:MF_01711} InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR014138 http://www.ebi.ac.uk/interpro/entry/IPR014138 InterPro IPR015857 http://www.ebi.ac.uk/interpro/entry/IPR015857 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3444 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3444 KEGG_Gene eco:b3479 http://www.genome.jp/dbget-bin/www_bget?eco:b3479 KEGG_Orthology KO:K15587 http://www.genome.jp/dbget-bin/www_bget?KO:K15587 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 MINT MINT-1262144 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1262144 OMA CHLLAND http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CHLLAND PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PROSITE PS51247 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51247 PSORT swissprot:NIKD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NIKD_ECOLI PSORT-B swissprot:NIKD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NIKD_ECOLI PSORT2 swissprot:NIKD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NIKD_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Phobius swissprot:NIKD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NIKD_ECOLI PhylomeDB P33593 http://phylomedb.org/?seqid=P33593 ProteinModelPortal P33593 http://www.proteinmodelportal.org/query/uniprot/P33593 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7934931 http://www.ncbi.nlm.nih.gov/pubmed/7934931 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417936 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417936 RefSeq WP_001136229 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001136229 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P33593 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33593 STRING 511145.b3479 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3479&targetmode=cogs STRING COG0444 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0444&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.5 http://www.tcdb.org/search/result.php?tc=3.A.1.5 TIGRFAMs TIGR02770 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02770 UniProtKB NIKD_ECOLI http://www.uniprot.org/uniprot/NIKD_ECOLI UniProtKB-AC P33593 http://www.uniprot.org/uniprot/P33593 charge swissprot:NIKD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NIKD_ECOLI eggNOG COG0444 http://eggnogapi.embl.de/nog_data/html/tree/COG0444 eggNOG ENOG4106665 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106665 epestfind swissprot:NIKD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NIKD_ECOLI garnier swissprot:NIKD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NIKD_ECOLI helixturnhelix swissprot:NIKD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NIKD_ECOLI hmoment swissprot:NIKD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NIKD_ECOLI iep swissprot:NIKD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NIKD_ECOLI inforesidue swissprot:NIKD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NIKD_ECOLI octanol swissprot:NIKD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NIKD_ECOLI pepcoil swissprot:NIKD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NIKD_ECOLI pepdigest swissprot:NIKD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NIKD_ECOLI pepinfo swissprot:NIKD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NIKD_ECOLI pepnet swissprot:NIKD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NIKD_ECOLI pepstats swissprot:NIKD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NIKD_ECOLI pepwheel swissprot:NIKD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NIKD_ECOLI pepwindow swissprot:NIKD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NIKD_ECOLI sigcleave swissprot:NIKD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NIKD_ECOLI ## Database ID URL or Descriptions # BioGrid 4262527 12 # CATALYTIC ACTIVITY Cyclic di-3',5'-guanylate + H(2)O = 5'- phosphoguanylyl(3'->5')guanosine. {ECO:0000269|PubMed 18765794}. # CDD cd01948 EAL # DISRUPTION PHENOTYPE YHJH_ECOLI Disruption leads to increased expression of adhesive curli fimbriae genes (PubMed 18765794), including CsgD (PubMed 19332833). Also leads to a severe reduction in swarm size and swimming velocity, and 80% reduced concentrations of c-di-GMP. Disruption of ycgR, or concomitant disruption of dosC, yegE, yedQ and yfiN completely restores motility, suggesting these 4 genes, together with this c-di-GMP phosphodiesterase, form a network that regulates cell motility by altering levels of c-di-GMP (PubMed 20303158). Overlapping but different results were seen by another group, where disruption of yeaJ, another probable diguanylate cyclase, partially suppresses the yhjH disruption, full suppression requires concomitant disruption of yeaJ, yedQ and yegE (PubMed 18765794). {ECO 0000269|PubMed 18765794, ECO 0000269|PubMed 19332833, ECO 0000269|PubMed 20303158, ECO 0000269|PubMed 20346719}. # EcoGene EG12252 yhjH # FUNCTION YHJH_ECOLI A bis-(3'-5') cyclic diguanylic acid (c-di-GMP) phosphodiesterase involved in regulating the levels of c-di-GMP that control cell motility (the flagella) and adhesion (adhesive curli fimbriae). The YhjH effect on flagella is controlled via the c-di-GMP-binding flagellar brake protein YcgR, however curli expression is not regulated via YcgR. Forms a network with different diguanylate cyclases (DosC, YeaJ, YedQ, YegE have been identified) to regulate c-di-GMP levels. Flagellar activity is high at low c-di-GMP levels whereas curli fimbria are induced at high c-di-GMP levels. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria. {ECO 0000269|PubMed 11031114}. # GO_function GO:0000166 nucleotide binding; IEA:UniProtKB-KW. # GO_function GO:0071111 cyclic-guanylate-specific phosphodiesterase activity; IDA:EcoCyc. # GO_process GO:0048870 cell motility; IMP:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0048870 cell motility # Gene3D 3.20.20.450 -; 1. # INDUCTION YHJH_ECOLI A class 3 flagellar gene, it is dependent on FliA for expression. Induced in early post-exponential phase at both 28 and 37 degrees Celsius, it shuts down later than class 1 and class 2 operon genes. Expression has to be shut down for adhesive curli fimbriae to be induced, i.e. on solid medium where biofilms form. Repressed by RpoS. {ECO 0000269|PubMed 18765794, ECO 0000269|PubMed 19332833}. # IntAct P37646 2 # InterPro IPR001633 EAL_dom # Organism YHJH_ECOLI Escherichia coli (strain K12) # PATRIC 32122512 VBIEscCol129921_3634 # PIR H65150 H65150 # PROSITE PS50883 EAL # Pfam PF00563 EAL # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHJH_ECOLI Cyclic di-GMP phosphodiesterase YhjH # RefSeq NP_417982 NC_000913.3 # RefSeq WP_001295219 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18502.1; Type=Frameshift; Positions=216; Evidence={ECO 0000305}; # SIMILARITY Contains 1 EAL domain. {ECO:0000255|PROSITE- ProRule PRU00074}. # SMART SM00052 EAL # SUPFAM SSF141868 SSF141868 # eggNOG ENOG4105CMB Bacteria # eggNOG ENOG410Z0RI LUCA BLAST swissprot:YHJH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHJH_ECOLI BioCyc ECOL316407:JW3493-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3493-MONOMER BioCyc EcoCyc:EG12252-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12252-MONOMER BioCyc MetaCyc:EG12252-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12252-MONOMER DOI 10.1006/jmbi.2000.4147 http://dx.doi.org/10.1006/jmbi.2000.4147 DOI 10.1016/j.cell.2010.01.018 http://dx.doi.org/10.1016/j.cell.2010.01.018 DOI 10.1016/j.molcel.2010.03.001 http://dx.doi.org/10.1016/j.molcel.2010.03.001 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1099/mic.0.024257-0 http://dx.doi.org/10.1099/mic.0.024257-0 DOI 10.1101/gad.475808 http://dx.doi.org/10.1101/gad.475808 DOI 10.1101/gad.499409 http://dx.doi.org/10.1101/gad.499409 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.4.52 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.4.52 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.4.52 http://enzyme.expasy.org/EC/3.1.4.52 EchoBASE EB2162 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2162 EcoGene EG12252 http://www.ecogene.org/geneInfo.php?eg_id=EG12252 EnsemblBacteria AAC76550 http://www.ensemblgenomes.org/id/AAC76550 EnsemblBacteria AAC76550 http://www.ensemblgenomes.org/id/AAC76550 EnsemblBacteria BAE77769 http://www.ensemblgenomes.org/id/BAE77769 EnsemblBacteria BAE77769 http://www.ensemblgenomes.org/id/BAE77769 EnsemblBacteria BAE77769 http://www.ensemblgenomes.org/id/BAE77769 EnsemblBacteria b3525 http://www.ensemblgenomes.org/id/b3525 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000166 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000166 GO_function GO:0071111 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071111 GO_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 Gene3D 3.20.20.450 http://www.cathdb.info/version/latest/superfamily/3.20.20.450 GeneID 948042 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948042 HOGENOM HOG000125902 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125902&db=HOGENOM6 InParanoid P37646 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37646 IntAct P37646 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37646* IntEnz 3.1.4.52 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.4.52 InterPro IPR001633 http://www.ebi.ac.uk/interpro/entry/IPR001633 KEGG_Gene ecj:JW3493 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3493 KEGG_Gene eco:b3525 http://www.genome.jp/dbget-bin/www_bget?eco:b3525 OMA ARDLFIM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ARDLFIM PROSITE PS50883 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50883 PSORT swissprot:YHJH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHJH_ECOLI PSORT-B swissprot:YHJH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHJH_ECOLI PSORT2 swissprot:YHJH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHJH_ECOLI Pfam PF00563 http://pfam.xfam.org/family/PF00563 Phobius swissprot:YHJH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHJH_ECOLI PhylomeDB P37646 http://phylomedb.org/?seqid=P37646 ProteinModelPortal P37646 http://www.proteinmodelportal.org/query/uniprot/P37646 PubMed 11031114 http://www.ncbi.nlm.nih.gov/pubmed/11031114 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18765794 http://www.ncbi.nlm.nih.gov/pubmed/18765794 PubMed 19240136 http://www.ncbi.nlm.nih.gov/pubmed/19240136 PubMed 19332833 http://www.ncbi.nlm.nih.gov/pubmed/19332833 PubMed 20303158 http://www.ncbi.nlm.nih.gov/pubmed/20303158 PubMed 20346719 http://www.ncbi.nlm.nih.gov/pubmed/20346719 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417982 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417982 RefSeq WP_001295219 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295219 SMART SM00052 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00052 SMR P37646 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37646 STRING 511145.b3525 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3525&targetmode=cogs SUPFAM SSF141868 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF141868 UniProtKB YHJH_ECOLI http://www.uniprot.org/uniprot/YHJH_ECOLI UniProtKB-AC P37646 http://www.uniprot.org/uniprot/P37646 charge swissprot:YHJH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHJH_ECOLI eggNOG ENOG4105CMB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CMB eggNOG ENOG410Z0RI http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Z0RI epestfind swissprot:YHJH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHJH_ECOLI garnier swissprot:YHJH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHJH_ECOLI helixturnhelix swissprot:YHJH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHJH_ECOLI hmoment swissprot:YHJH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHJH_ECOLI iep swissprot:YHJH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHJH_ECOLI inforesidue swissprot:YHJH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHJH_ECOLI octanol swissprot:YHJH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHJH_ECOLI pepcoil swissprot:YHJH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHJH_ECOLI pepdigest swissprot:YHJH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHJH_ECOLI pepinfo swissprot:YHJH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHJH_ECOLI pepnet swissprot:YHJH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHJH_ECOLI pepstats swissprot:YHJH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHJH_ECOLI pepwheel swissprot:YHJH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHJH_ECOLI pepwindow swissprot:YHJH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHJH_ECOLI sigcleave swissprot:YHJH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHJH_ECOLI ## Database ID URL or Descriptions # BioGrid 4260875 7 # CDD cd06259 YdcF-like # EcoGene EG12728 ygjQ # GO_component GO:0005886 plasma membrane; IBA:GO_Central. # GO_component GO:0016021 integral component of membrane; IBA:GO_Central. # GO_process GO:0042493 response to drug; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.620 -; 1. # IntAct P42598 8 # InterPro IPR003848 DUF218 # InterPro IPR014729 Rossmann-like_a/b/a_fold # Organism YGJQ_ECOLI Escherichia coli (strain K12) # PATRIC 32121590 VBIEscCol129921_3181 # PIR C65097 C65097 # Pfam PF02698 DUF218 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGJQ_ECOLI Uncharacterized protein YgjQ # RefSeq NP_417557 NC_000913.3 # RefSeq WP_000942548 NZ_LN832404.1 # SIMILARITY To E.coli SanA. {ECO 0000305}. # SUBCELLULAR LOCATION YGJQ_ECOLI Membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. # eggNOG COG2949 LUCA # eggNOG ENOG4108UB4 Bacteria BLAST swissprot:YGJQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGJQ_ECOLI BioCyc ECOL316407:JW3057-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3057-MONOMER BioCyc EcoCyc:G7605-MONOMER http://biocyc.org/getid?id=EcoCyc:G7605-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2587 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2587 EcoGene EG12728 http://www.ecogene.org/geneInfo.php?eg_id=EG12728 EnsemblBacteria AAC76121 http://www.ensemblgenomes.org/id/AAC76121 EnsemblBacteria AAC76121 http://www.ensemblgenomes.org/id/AAC76121 EnsemblBacteria BAE77136 http://www.ensemblgenomes.org/id/BAE77136 EnsemblBacteria BAE77136 http://www.ensemblgenomes.org/id/BAE77136 EnsemblBacteria BAE77136 http://www.ensemblgenomes.org/id/BAE77136 EnsemblBacteria b3086 http://www.ensemblgenomes.org/id/b3086 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0042493 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 GeneID 947598 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947598 HOGENOM HOG000031180 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000031180&db=HOGENOM6 InParanoid P42598 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P42598 IntAct P42598 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P42598* InterPro IPR003848 http://www.ebi.ac.uk/interpro/entry/IPR003848 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 KEGG_Gene ecj:JW3057 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3057 KEGG_Gene eco:b3086 http://www.genome.jp/dbget-bin/www_bget?eco:b3086 OMA PHFLGPR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PHFLGPR PSORT swissprot:YGJQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGJQ_ECOLI PSORT-B swissprot:YGJQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGJQ_ECOLI PSORT2 swissprot:YGJQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGJQ_ECOLI Pfam PF02698 http://pfam.xfam.org/family/PF02698 Phobius swissprot:YGJQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGJQ_ECOLI PhylomeDB P42598 http://phylomedb.org/?seqid=P42598 ProteinModelPortal P42598 http://www.proteinmodelportal.org/query/uniprot/P42598 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417557 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417557 RefSeq WP_000942548 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000942548 SMR P42598 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P42598 STRING 511145.b3086 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3086&targetmode=cogs UniProtKB YGJQ_ECOLI http://www.uniprot.org/uniprot/YGJQ_ECOLI UniProtKB-AC P42598 http://www.uniprot.org/uniprot/P42598 charge swissprot:YGJQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGJQ_ECOLI eggNOG COG2949 http://eggnogapi.embl.de/nog_data/html/tree/COG2949 eggNOG ENOG4108UB4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UB4 epestfind swissprot:YGJQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGJQ_ECOLI garnier swissprot:YGJQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGJQ_ECOLI helixturnhelix swissprot:YGJQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGJQ_ECOLI hmoment swissprot:YGJQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGJQ_ECOLI iep swissprot:YGJQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGJQ_ECOLI inforesidue swissprot:YGJQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGJQ_ECOLI octanol swissprot:YGJQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGJQ_ECOLI pepcoil swissprot:YGJQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGJQ_ECOLI pepdigest swissprot:YGJQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGJQ_ECOLI pepinfo swissprot:YGJQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGJQ_ECOLI pepnet swissprot:YGJQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGJQ_ECOLI pepstats swissprot:YGJQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGJQ_ECOLI pepwheel swissprot:YGJQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGJQ_ECOLI pepwindow swissprot:YGJQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGJQ_ECOLI sigcleave swissprot:YGJQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGJQ_ECOLI ## Database ID URL or Descriptions # BRENDA 3.1.4.14 2026 # BioGrid 4261717 13 # CATALYTIC ACTIVITY ACPH_ECOLI Holo-[acyl-carrier-protein] + H(2)O = 4'- phosphopantetheine + apo-[acyl-carrier-protein]. {ECO 0000255|HAMAP-Rule MF_01950, ECO 0000269|PubMed 16107329}. # EcoGene EG11095 acpH # FUNCTION ACPH_ECOLI Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP. {ECO 0000255|HAMAP-Rule MF_01950, ECO 0000269|PubMed 16107329}. # GO_function GO:0008770 [acyl-carrier-protein] phosphodiesterase activity; IDA:EcoCyc. # GO_process GO:0006633 fatty acid biosynthetic process; IDA:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # HAMAP MF_01950 AcpH # IntAct P21515 2 # InterPro IPR007431 ACP_phosphodiesterase # InterPro IPR023491 ACP_phosphodiesterase_gpbac # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00770 Pantothenate and CoA biosynthesis # Organism ACPH_ECOLI Escherichia coli (strain K12) # PATRIC 32115957 VBIEscCol129921_0420 # PIR D64769 D64769 # PIRSF PIRSF011489 DUF479 # Pfam PF04336 DUF479 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Acyl carrier protein phosphodiesterase {ECO:0000255|HAMAP-Rule MF_01950} # RefSeq NP_414938 NC_000913.3 # RefSeq WP_001009885 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA16113.1; Type=Frameshift; Positions=71; Evidence={ECO 0000305}; # SIMILARITY Belongs to the AcpH family. {ECO:0000255|HAMAP- Rule MF_01950}. # eggNOG COG3124 LUCA # eggNOG ENOG4108ZYK Bacteria BLAST swissprot:ACPH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ACPH_ECOLI BioCyc ECOL316407:JW0394-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0394-MONOMER BioCyc EcoCyc:EG11095-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11095-MONOMER BioCyc MetaCyc:EG11095-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11095-MONOMER COG COG3124 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3124 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M505736200 http://dx.doi.org/10.1074/jbc.M505736200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.4.14 {ECO:0000255|HAMAP-Rule:MF_01950} http://www.genome.jp/dbget-bin/www_bget?EC:3.1.4.14 {ECO:0000255|HAMAP-Rule:MF_01950} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M37702 http://www.ebi.ac.uk/ena/data/view/M37702 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 ENZYME 3.1.4.14 {ECO:0000255|HAMAP-Rule:MF_01950} http://enzyme.expasy.org/EC/3.1.4.14 {ECO:0000255|HAMAP-Rule:MF_01950} EchoBASE EB1087 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1087 EcoGene EG11095 http://www.ecogene.org/geneInfo.php?eg_id=EG11095 EnsemblBacteria AAC73507 http://www.ensemblgenomes.org/id/AAC73507 EnsemblBacteria AAC73507 http://www.ensemblgenomes.org/id/AAC73507 EnsemblBacteria BAE76184 http://www.ensemblgenomes.org/id/BAE76184 EnsemblBacteria BAE76184 http://www.ensemblgenomes.org/id/BAE76184 EnsemblBacteria BAE76184 http://www.ensemblgenomes.org/id/BAE76184 EnsemblBacteria b0404 http://www.ensemblgenomes.org/id/b0404 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008770 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008770 GO_process GO:0006633 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006633 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 949132 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949132 HAMAP MF_01950 http://hamap.expasy.org/unirule/MF_01950 HOGENOM HOG000275880 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275880&db=HOGENOM6 InParanoid P21515 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P21515 IntAct P21515 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P21515* IntEnz 3.1.4.14 {ECO:0000255|HAMAP-Rule:MF_01950} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.4.14 {ECO:0000255|HAMAP-Rule:MF_01950} InterPro IPR007431 http://www.ebi.ac.uk/interpro/entry/IPR007431 InterPro IPR023491 http://www.ebi.ac.uk/interpro/entry/IPR023491 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0394 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0394 KEGG_Gene eco:b0404 http://www.genome.jp/dbget-bin/www_bget?eco:b0404 KEGG_Orthology KO:K08682 http://www.genome.jp/dbget-bin/www_bget?KO:K08682 KEGG_Pathway ko00770 http://www.genome.jp/kegg-bin/show_pathway?ko00770 KEGG_Reaction rn:R01623 http://www.genome.jp/dbget-bin/www_bget?rn:R01623 OMA MNFLAHI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MNFLAHI PSORT swissprot:ACPH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ACPH_ECOLI PSORT-B swissprot:ACPH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ACPH_ECOLI PSORT2 swissprot:ACPH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ACPH_ECOLI Pfam PF04336 http://pfam.xfam.org/family/PF04336 Phobius swissprot:ACPH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ACPH_ECOLI PhylomeDB P21515 http://phylomedb.org/?seqid=P21515 ProteinModelPortal P21515 http://www.proteinmodelportal.org/query/uniprot/P21515 PubMed 16107329 http://www.ncbi.nlm.nih.gov/pubmed/16107329 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1706703 http://www.ncbi.nlm.nih.gov/pubmed/1706703 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414938 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414938 RefSeq WP_001009885 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001009885 STRING 511145.b0404 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0404&targetmode=cogs STRING COG3124 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3124&targetmode=cogs UniProtKB ACPH_ECOLI http://www.uniprot.org/uniprot/ACPH_ECOLI UniProtKB-AC P21515 http://www.uniprot.org/uniprot/P21515 charge swissprot:ACPH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ACPH_ECOLI eggNOG COG3124 http://eggnogapi.embl.de/nog_data/html/tree/COG3124 eggNOG ENOG4108ZYK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZYK epestfind swissprot:ACPH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ACPH_ECOLI garnier swissprot:ACPH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ACPH_ECOLI helixturnhelix swissprot:ACPH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ACPH_ECOLI hmoment swissprot:ACPH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ACPH_ECOLI iep swissprot:ACPH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ACPH_ECOLI inforesidue swissprot:ACPH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ACPH_ECOLI octanol swissprot:ACPH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ACPH_ECOLI pepcoil swissprot:ACPH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ACPH_ECOLI pepdigest swissprot:ACPH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ACPH_ECOLI pepinfo swissprot:ACPH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ACPH_ECOLI pepnet swissprot:ACPH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ACPH_ECOLI pepstats swissprot:ACPH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ACPH_ECOLI pepwheel swissprot:ACPH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ACPH_ECOLI pepwindow swissprot:ACPH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ACPH_ECOLI sigcleave swissprot:ACPH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ACPH_ECOLI ## Database ID URL or Descriptions # BioGrid 4260911 9 # EcoGene EG10006 dcuB # FUNCTION DCUB_ECOLI Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015556 C4-dicarboxylate transmembrane transporter activity; IEA:InterPro. # GO_process GO:0015740 C4-dicarboxylate transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR004668 Anaer_Dcu_memb_transpt # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko02020 Two-component system # Organism DCUB_ECOLI Escherichia coli (strain K12) # PATRIC 32123811 VBIEscCol129921_4254 # PIR S56352 S56352 # PIRSF PIRSF004539 C4-dicrbxl_trns # Pfam PF03605 DcuA_DcuB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DCUB_ECOLI Anaerobic C4-dicarboxylate transporter DcuB # RefSeq NP_418547 NC_000913.3 # RefSeq WP_000899522 NZ_LN832404.1 # SIMILARITY Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family. {ECO 0000305}. # SUBCELLULAR LOCATION DCUB_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.13.1 the c4-dicarboxylate uptake (dcu) family # TIGRFAMs TIGR00770 Dcu # eggNOG COG2704 LUCA # eggNOG ENOG4105DS2 Bacteria BLAST swissprot:DCUB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DCUB_ECOLI BioCyc ECOL316407:JW4084-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4084-MONOMER BioCyc EcoCyc:DCUB-MONOMER http://biocyc.org/getid?id=EcoCyc:DCUB-MONOMER BioCyc MetaCyc:DCUB-MONOMER http://biocyc.org/getid?id=MetaCyc:DCUB-MONOMER COG COG2704 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2704 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bst021342s http://dx.doi.org/10.1042/bst021342s DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M27058 http://www.ebi.ac.uk/ena/data/view/M27058 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X79886 http://www.ebi.ac.uk/ena/data/view/X79886 EchoBASE EB0006 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0006 EcoGene EG10006 http://www.ecogene.org/geneInfo.php?eg_id=EG10006 EnsemblBacteria AAC77084 http://www.ensemblgenomes.org/id/AAC77084 EnsemblBacteria AAC77084 http://www.ensemblgenomes.org/id/AAC77084 EnsemblBacteria BAE78125 http://www.ensemblgenomes.org/id/BAE78125 EnsemblBacteria BAE78125 http://www.ensemblgenomes.org/id/BAE78125 EnsemblBacteria BAE78125 http://www.ensemblgenomes.org/id/BAE78125 EnsemblBacteria b4123 http://www.ensemblgenomes.org/id/b4123 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015556 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015556 GO_process GO:0015740 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015740 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948641 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948641 HOGENOM HOG000272417 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000272417&db=HOGENOM6 InParanoid P0ABN9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABN9 InterPro IPR004668 http://www.ebi.ac.uk/interpro/entry/IPR004668 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW4084 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4084 KEGG_Gene eco:b4123 http://www.genome.jp/dbget-bin/www_bget?eco:b4123 KEGG_Orthology KO:K07792 http://www.genome.jp/dbget-bin/www_bget?KO:K07792 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA DKDPEFQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DKDPEFQ PSORT swissprot:DCUB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DCUB_ECOLI PSORT-B swissprot:DCUB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DCUB_ECOLI PSORT2 swissprot:DCUB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DCUB_ECOLI Pfam PF03605 http://pfam.xfam.org/family/PF03605 Phobius swissprot:DCUB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DCUB_ECOLI PhylomeDB P0ABN9 http://phylomedb.org/?seqid=P0ABN9 ProteinModelPortal P0ABN9 http://www.proteinmodelportal.org/query/uniprot/P0ABN9 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2656658 http://www.ncbi.nlm.nih.gov/pubmed/2656658 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 7961398 http://www.ncbi.nlm.nih.gov/pubmed/7961398 PubMed 8131924 http://www.ncbi.nlm.nih.gov/pubmed/8131924 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418547 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418547 RefSeq WP_000899522 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000899522 STRING 511145.b4123 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4123&targetmode=cogs STRING COG2704 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2704&targetmode=cogs TCDB 2.A.13.1 http://www.tcdb.org/search/result.php?tc=2.A.13.1 TIGRFAMs TIGR00770 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00770 UniProtKB DCUB_ECOLI http://www.uniprot.org/uniprot/DCUB_ECOLI UniProtKB-AC P0ABN9 http://www.uniprot.org/uniprot/P0ABN9 charge swissprot:DCUB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DCUB_ECOLI eggNOG COG2704 http://eggnogapi.embl.de/nog_data/html/tree/COG2704 eggNOG ENOG4105DS2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DS2 epestfind swissprot:DCUB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DCUB_ECOLI garnier swissprot:DCUB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DCUB_ECOLI helixturnhelix swissprot:DCUB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DCUB_ECOLI hmoment swissprot:DCUB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DCUB_ECOLI iep swissprot:DCUB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DCUB_ECOLI inforesidue swissprot:DCUB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DCUB_ECOLI octanol swissprot:DCUB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DCUB_ECOLI pepcoil swissprot:DCUB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DCUB_ECOLI pepdigest swissprot:DCUB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DCUB_ECOLI pepinfo swissprot:DCUB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DCUB_ECOLI pepnet swissprot:DCUB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DCUB_ECOLI pepstats swissprot:DCUB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DCUB_ECOLI pepwheel swissprot:DCUB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DCUB_ECOLI pepwindow swissprot:DCUB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DCUB_ECOLI sigcleave swissprot:DCUB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DCUB_ECOLI ## Database ID URL or Descriptions # AltName RLUE_ECOLI rRNA pseudouridylate synthase E # AltName RLUE_ECOLI rRNA-uridine isomerase E # BRENDA 5.4.99.20 2026 # BioGrid 4263127 17 # CATALYTIC ACTIVITY 23S rRNA uridine(2457) = 23S rRNA pseudouridine(2457). {ECO:0000269|PubMed 11720289}. # EcoGene EG13447 rluE # FUNCTION RLUE_ECOLI Responsible for synthesis of pseudouridine from uracil- 2457 in 23S ribosomal RNA. {ECO 0000269|PubMed 11720289}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0003723 RNA binding; IEA:InterPro. # GO_function GO:0009982 pseudouridine synthase activity; IMP:EcoCyc. # GO_process GO:0000455 enzyme-directed rRNA pseudouridine synthesis; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # IntAct P75966 8 # InterPro IPR000748 PsdUridine_synth_RsuA/RluB/E/F # InterPro IPR006145 PsdUridine_synth_RsuA/RluD # InterPro IPR018496 PsdUridine_synth_RsuA/RluB_CS # InterPro IPR020103 PsdUridine_synth_cat_dom # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # Organism RLUE_ECOLI Escherichia coli (strain K12) # PATRIC 32117519 VBIEscCol129921_1182 # PDB 2OLW X-ray; 1.60 A; A/B=1-217 # PDB 2OML X-ray; 1.20 A; A=29-217 # PIR D64858 D64858 # PROSITE PS01149 PSI_RSU # Pfam PF00849 PseudoU_synth_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RLUE_ECOLI Ribosomal large subunit pseudouridine synthase E # RefSeq NP_415653 NC_000913.3 # RefSeq WP_001248691 NZ_LN832404.1 # SIMILARITY Belongs to the pseudouridine synthase RsuA family. {ECO 0000305}. # SUPFAM SSF55120 SSF55120 # TIGRFAMs TIGR00093 TIGR00093 # eggNOG COG1187 LUCA # eggNOG ENOG4108R99 Bacteria BLAST swissprot:RLUE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RLUE_ECOLI BioCyc ECOL316407:JW1121-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1121-MONOMER BioCyc EcoCyc:G6581-MONOMER http://biocyc.org/getid?id=EcoCyc:G6581-MONOMER BioCyc MetaCyc:G6581-MONOMER http://biocyc.org/getid?id=MetaCyc:G6581-MONOMER COG COG1187 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1187 DIP DIP-12716N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12716N DOI 10.1016/j.jmb.2007.01.084 http://dx.doi.org/10.1016/j.jmb.2007.01.084 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.4.99.20 http://www.genome.jp/dbget-bin/www_bget?EC:5.4.99.20 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 5.4.99.20 http://enzyme.expasy.org/EC/5.4.99.20 EchoBASE EB3221 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3221 EcoGene EG13447 http://www.ecogene.org/geneInfo.php?eg_id=EG13447 EnsemblBacteria AAC74219 http://www.ensemblgenomes.org/id/AAC74219 EnsemblBacteria AAC74219 http://www.ensemblgenomes.org/id/AAC74219 EnsemblBacteria BAA35957 http://www.ensemblgenomes.org/id/BAA35957 EnsemblBacteria BAA35957 http://www.ensemblgenomes.org/id/BAA35957 EnsemblBacteria BAA35957 http://www.ensemblgenomes.org/id/BAA35957 EnsemblBacteria b1135 http://www.ensemblgenomes.org/id/b1135 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0009982 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009982 GO_process GO:0000455 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000455 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 945701 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945701 HOGENOM HOG000044955 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000044955&db=HOGENOM6 InParanoid P75966 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75966 IntAct P75966 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75966* IntEnz 5.4.99.20 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.4.99.20 InterPro IPR000748 http://www.ebi.ac.uk/interpro/entry/IPR000748 InterPro IPR006145 http://www.ebi.ac.uk/interpro/entry/IPR006145 InterPro IPR018496 http://www.ebi.ac.uk/interpro/entry/IPR018496 InterPro IPR020103 http://www.ebi.ac.uk/interpro/entry/IPR020103 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW1121 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1121 KEGG_Gene eco:b1135 http://www.genome.jp/dbget-bin/www_bget?eco:b1135 KEGG_Orthology KO:K06181 http://www.genome.jp/dbget-bin/www_bget?KO:K06181 OMA FRKHRVE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FRKHRVE PDB 2OLW http://www.ebi.ac.uk/pdbe-srv/view/entry/2OLW PDB 2OML http://www.ebi.ac.uk/pdbe-srv/view/entry/2OML PDBsum 2OLW http://www.ebi.ac.uk/pdbsum/2OLW PDBsum 2OML http://www.ebi.ac.uk/pdbsum/2OML PROSITE PS01149 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01149 PSORT swissprot:RLUE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RLUE_ECOLI PSORT-B swissprot:RLUE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RLUE_ECOLI PSORT2 swissprot:RLUE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RLUE_ECOLI Pfam PF00849 http://pfam.xfam.org/family/PF00849 Phobius swissprot:RLUE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RLUE_ECOLI PhylomeDB P75966 http://phylomedb.org/?seqid=P75966 ProteinModelPortal P75966 http://www.proteinmodelportal.org/query/uniprot/P75966 PubMed 11720289 http://www.ncbi.nlm.nih.gov/pubmed/11720289 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17320904 http://www.ncbi.nlm.nih.gov/pubmed/17320904 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415653 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415653 RefSeq WP_001248691 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001248691 SMR P75966 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75966 STRING 511145.b1135 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1135&targetmode=cogs STRING COG1187 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1187&targetmode=cogs SUPFAM SSF55120 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55120 TIGRFAMs TIGR00093 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00093 UniProtKB RLUE_ECOLI http://www.uniprot.org/uniprot/RLUE_ECOLI UniProtKB-AC P75966 http://www.uniprot.org/uniprot/P75966 charge swissprot:RLUE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RLUE_ECOLI eggNOG COG1187 http://eggnogapi.embl.de/nog_data/html/tree/COG1187 eggNOG ENOG4108R99 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108R99 epestfind swissprot:RLUE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RLUE_ECOLI garnier swissprot:RLUE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RLUE_ECOLI helixturnhelix swissprot:RLUE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RLUE_ECOLI hmoment swissprot:RLUE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RLUE_ECOLI iep swissprot:RLUE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RLUE_ECOLI inforesidue swissprot:RLUE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RLUE_ECOLI octanol swissprot:RLUE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RLUE_ECOLI pepcoil swissprot:RLUE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RLUE_ECOLI pepdigest swissprot:RLUE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RLUE_ECOLI pepinfo swissprot:RLUE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RLUE_ECOLI pepnet swissprot:RLUE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RLUE_ECOLI pepstats swissprot:RLUE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RLUE_ECOLI pepwheel swissprot:RLUE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RLUE_ECOLI pepwindow swissprot:RLUE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RLUE_ECOLI sigcleave swissprot:RLUE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RLUE_ECOLI ## Database ID URL or Descriptions # BioGrid 4262410 9 # CDD cd07377 WHTH_GntR # EcoGene EG12739 exuR # FUNCTION EXUR_ECOLI Repressor for the exu regulon that encode genes involved in hexuronate utilization. It regulates the ExuT, UxaCA and UxuRAB operons. Binds D-tagaturonate and D-fructuronate as inducers. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IMP:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # Gene3D 1.20.120.530 -; 1. # IntAct P0ACL2 3 # InterPro IPR000524 Tscrpt_reg_HTH_GntR # InterPro IPR008920 TF_FadR/GntR_C # InterPro IPR011711 GntR_C # InterPro IPR011991 WHTH_DNA-bd_dom # Organism EXUR_ECOLI Escherichia coli (strain K12) # PATRIC 32121606 VBIEscCol129921_3189 # PIR C65098 C65098 # PRINTS PR00035 HTHGNTR # PROSITE PS50949 HTH_GNTR # Pfam PF00392 GntR # Pfam PF07729 FCD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EXUR_ECOLI Exu regulon transcriptional regulator # RefSeq NP_417565 NC_000913.3 # RefSeq WP_000406488 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA57898.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Contains 1 HTH gntR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00307}. # SMART SM00345 HTH_GNTR # SMART SM00895 FCD # SUPFAM SSF46785 SSF46785 # SUPFAM SSF48008 SSF48008 # eggNOG COG2186 LUCA # eggNOG ENOG4107YCY Bacteria BLAST swissprot:EXUR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EXUR_ECOLI BioCyc ECOL316407:JW3065-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3065-MONOMER BioCyc EcoCyc:PD03270 http://biocyc.org/getid?id=EcoCyc:PD03270 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D13328 http://www.ebi.ac.uk/ena/data/view/D13328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2595 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2595 EcoGene EG12739 http://www.ecogene.org/geneInfo.php?eg_id=EG12739 EnsemblBacteria AAC76129 http://www.ensemblgenomes.org/id/AAC76129 EnsemblBacteria AAC76129 http://www.ensemblgenomes.org/id/AAC76129 EnsemblBacteria BAE77144 http://www.ensemblgenomes.org/id/BAE77144 EnsemblBacteria BAE77144 http://www.ensemblgenomes.org/id/BAE77144 EnsemblBacteria BAE77144 http://www.ensemblgenomes.org/id/BAE77144 EnsemblBacteria b3094 http://www.ensemblgenomes.org/id/b3094 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 1.20.120.530 http://www.cathdb.info/version/latest/superfamily/1.20.120.530 GeneID 947602 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947602 HOGENOM HOG000273991 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000273991&db=HOGENOM6 InParanoid P0ACL2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACL2 IntAct P0ACL2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACL2* InterPro IPR000524 http://www.ebi.ac.uk/interpro/entry/IPR000524 InterPro IPR008920 http://www.ebi.ac.uk/interpro/entry/IPR008920 InterPro IPR011711 http://www.ebi.ac.uk/interpro/entry/IPR011711 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW3065 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3065 KEGG_Gene eco:b3094 http://www.genome.jp/dbget-bin/www_bget?eco:b3094 OMA YLFADNP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YLFADNP PRINTS PR00035 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00035 PROSITE PS50949 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50949 PSORT swissprot:EXUR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EXUR_ECOLI PSORT-B swissprot:EXUR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EXUR_ECOLI PSORT2 swissprot:EXUR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EXUR_ECOLI Pfam PF00392 http://pfam.xfam.org/family/PF00392 Pfam PF07729 http://pfam.xfam.org/family/PF07729 Phobius swissprot:EXUR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EXUR_ECOLI PhylomeDB P0ACL2 http://phylomedb.org/?seqid=P0ACL2 ProteinModelPortal P0ACL2 http://www.proteinmodelportal.org/query/uniprot/P0ACL2 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417565 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417565 RefSeq WP_000406488 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000406488 SMART SM00345 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00345 SMART SM00895 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00895 SMR P0ACL2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACL2 STRING 511145.b3094 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3094&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SUPFAM SSF48008 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48008 UniProtKB EXUR_ECOLI http://www.uniprot.org/uniprot/EXUR_ECOLI UniProtKB-AC P0ACL2 http://www.uniprot.org/uniprot/P0ACL2 charge swissprot:EXUR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EXUR_ECOLI eggNOG COG2186 http://eggnogapi.embl.de/nog_data/html/tree/COG2186 eggNOG ENOG4107YCY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107YCY epestfind swissprot:EXUR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EXUR_ECOLI garnier swissprot:EXUR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EXUR_ECOLI helixturnhelix swissprot:EXUR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EXUR_ECOLI hmoment swissprot:EXUR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EXUR_ECOLI iep swissprot:EXUR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EXUR_ECOLI inforesidue swissprot:EXUR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EXUR_ECOLI octanol swissprot:EXUR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EXUR_ECOLI pepcoil swissprot:EXUR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EXUR_ECOLI pepdigest swissprot:EXUR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EXUR_ECOLI pepinfo swissprot:EXUR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EXUR_ECOLI pepnet swissprot:EXUR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EXUR_ECOLI pepstats swissprot:EXUR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EXUR_ECOLI pepwheel swissprot:EXUR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EXUR_ECOLI pepwindow swissprot:EXUR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EXUR_ECOLI sigcleave swissprot:EXUR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EXUR_ECOLI ## Database ID URL or Descriptions # AltName OTSA_ECOLI Osmoregulatory trehalose synthesis protein A # AltName OTSA_ECOLI Trehalose-6-phosphate synthase # AltName OTSA_ECOLI UDP-glucose-glucosephosphate glucosyltransferase # BioGrid 4259473 8 # CATALYTIC ACTIVITY OTSA_ECOLI UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate. # CAZy GT20 Glycosyltransferase Family 20 # CDD cd03788 GT1_TPS # DISRUPTION PHENOTYPE Mutants are viable, but osmotically sensitive in minimal media and sensitive to cold shock. {ECO:0000269|PubMed 3131312}. # ENZYME REGULATION Activated by potassium and other monovalent cations at 0.25 M. Partially inhibited at greater concentrations. {ECO:0000269|PubMed 3131312}. # EcoGene EG11751 otsA # FUNCTION OTSA_ECOLI Catalyzes the transfer of glucose from UDP-glucose to glucose-6-phosphate to form alpha,alpha-1,1 trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor. Essential for viability of the cells at low temperatures and at elevated osmotic strength. {ECO 0000269|PubMed 12105274, ECO 0000269|PubMed 1310094, ECO 0000269|PubMed 3131312}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity; IDA:EcoCyc. # GO_function GO:0004805 trehalose-phosphatase activity; IBA:GO_Central. # GO_process GO:0005992 trehalose biosynthetic process; IMP:EcoCyc. # GO_process GO:0006970 response to osmotic stress; IMP:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0070415 trehalose metabolism in response to cold stress; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_function GO:0016791 phosphatase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # INDUCTION OTSA_ECOLI By cold-shock, osmotic-shock and during the transition to stationary phase. Expression is partially dependent on RpoS. {ECO 0000269|PubMed 12105274, ECO 0000269|PubMed 1310094, ECO 0000269|PubMed 1744047, ECO 0000269|PubMed 3131312}. # InterPro IPR001830 Glyco_trans_20 # InterPro IPR012766 Trehalose_OtsA # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01003 Glycosyltransferases # KEGG_Pathway ko00500 Starch and sucrose metabolism # Organism OTSA_ECOLI Escherichia coli (strain K12) # PATHWAY OTSA_ECOLI Glycan biosynthesis; trehalose biosynthesis. # PATRIC 32119119 VBIEscCol129921_1977 # PDB 1GZ5 X-ray; 2.43 A; A/B/C/D=2-457 # PDB 1UQT X-ray; 2.00 A; A/B=2-474 # PDB 1UQU X-ray; 2.00 A; A/B=2-474 # PDB 2WTX X-ray; 2.20 A; A/B/C/D=1-474 # PIR I83402 I83402 # Pfam PF00982 Glyco_transf_20 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName OTSA_ECOLI Alpha,alpha-trehalose-phosphate synthase [UDP-forming] # RefSeq NP_416410 NC_000913.3 # RefSeq WP_001295646 NZ_LN832404.1 # SIMILARITY Belongs to the glycosyltransferase 20 family. {ECO 0000305}. # SUBUNIT Homotetramer. {ECO:0000269|PubMed 12498887}. # TIGRFAMs TIGR02400 trehalose_OtsA # eggNOG COG0380 LUCA # eggNOG ENOG4105C1K Bacteria BLAST swissprot:OTSA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:OTSA_ECOLI BioCyc ECOL316407:JW5312-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5312-MONOMER BioCyc EcoCyc:TREHALOSE6PSYN-MONOMER http://biocyc.org/getid?id=EcoCyc:TREHALOSE6PSYN-MONOMER BioCyc MetaCyc:TREHALOSE6PSYN-MONOMER http://biocyc.org/getid?id=MetaCyc:TREHALOSE6PSYN-MONOMER COG COG0380 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0380 DIP DIP-10417N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10417N DOI 10.1016/0378-1119(94)90316-6 http://dx.doi.org/10.1016/0378-1119(94)90316-6 DOI 10.1016/S1074-5521(02)00292-2 http://dx.doi.org/10.1016/S1074-5521(02)00292-2 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.142314099 http://dx.doi.org/10.1073/pnas.142314099 DOI 10.1074/jbc.M307643200 http://dx.doi.org/10.1074/jbc.M307643200 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.4.1.15 http://www.genome.jp/dbget-bin/www_bget?EC:2.4.1.15 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U27211 http://www.ebi.ac.uk/ena/data/view/U27211 EMBL X69160 http://www.ebi.ac.uk/ena/data/view/X69160 ENZYME 2.4.1.15 http://enzyme.expasy.org/EC/2.4.1.15 EchoBASE EB1701 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1701 EcoGene EG11751 http://www.ecogene.org/geneInfo.php?eg_id=EG11751 EnsemblBacteria AAC74966 http://www.ensemblgenomes.org/id/AAC74966 EnsemblBacteria AAC74966 http://www.ensemblgenomes.org/id/AAC74966 EnsemblBacteria BAA15717 http://www.ensemblgenomes.org/id/BAA15717 EnsemblBacteria BAA15717 http://www.ensemblgenomes.org/id/BAA15717 EnsemblBacteria BAA15717 http://www.ensemblgenomes.org/id/BAA15717 EnsemblBacteria b1896 http://www.ensemblgenomes.org/id/b1896 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003825 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003825 GO_function GO:0004805 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004805 GO_process GO:0005992 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005992 GO_process GO:0006970 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006970 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0070415 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070415 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 946405 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946405 HOGENOM HOG000191478 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000191478&db=HOGENOM6 InParanoid P31677 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31677 IntEnz 2.4.1.15 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.1.15 InterPro IPR001830 http://www.ebi.ac.uk/interpro/entry/IPR001830 InterPro IPR012766 http://www.ebi.ac.uk/interpro/entry/IPR012766 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01003 http://www.genome.jp/dbget-bin/www_bget?ko01003 KEGG_Gene ecj:JW5312 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5312 KEGG_Gene eco:b1896 http://www.genome.jp/dbget-bin/www_bget?eco:b1896 KEGG_Orthology KO:K00697 http://www.genome.jp/dbget-bin/www_bget?KO:K00697 KEGG_Pathway ko00500 http://www.genome.jp/kegg-bin/show_pathway?ko00500 KEGG_Reaction rn:R02737 http://www.genome.jp/dbget-bin/www_bget?rn:R02737 OMA IEFMPIH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IEFMPIH PDB 1GZ5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1GZ5 PDB 1UQT http://www.ebi.ac.uk/pdbe-srv/view/entry/1UQT PDB 1UQU http://www.ebi.ac.uk/pdbe-srv/view/entry/1UQU PDB 2WTX http://www.ebi.ac.uk/pdbe-srv/view/entry/2WTX PDBsum 1GZ5 http://www.ebi.ac.uk/pdbsum/1GZ5 PDBsum 1UQT http://www.ebi.ac.uk/pdbsum/1UQT PDBsum 1UQU http://www.ebi.ac.uk/pdbsum/1UQU PDBsum 2WTX http://www.ebi.ac.uk/pdbsum/2WTX PSORT swissprot:OTSA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:OTSA_ECOLI PSORT-B swissprot:OTSA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:OTSA_ECOLI PSORT2 swissprot:OTSA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:OTSA_ECOLI Pfam PF00982 http://pfam.xfam.org/family/PF00982 Phobius swissprot:OTSA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:OTSA_ECOLI PhylomeDB P31677 http://phylomedb.org/?seqid=P31677 ProteinModelPortal P31677 http://www.proteinmodelportal.org/query/uniprot/P31677 PubMed 12105274 http://www.ncbi.nlm.nih.gov/pubmed/12105274 PubMed 12498887 http://www.ncbi.nlm.nih.gov/pubmed/12498887 PubMed 1310094 http://www.ncbi.nlm.nih.gov/pubmed/1310094 PubMed 14570926 http://www.ncbi.nlm.nih.gov/pubmed/14570926 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1744047 http://www.ncbi.nlm.nih.gov/pubmed/1744047 PubMed 3131312 http://www.ncbi.nlm.nih.gov/pubmed/3131312 PubMed 8045430 http://www.ncbi.nlm.nih.gov/pubmed/8045430 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416410 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416410 RefSeq WP_001295646 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295646 SMR P31677 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31677 STRING 511145.b1896 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1896&targetmode=cogs STRING COG0380 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0380&targetmode=cogs TIGRFAMs TIGR02400 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02400 UniProtKB OTSA_ECOLI http://www.uniprot.org/uniprot/OTSA_ECOLI UniProtKB-AC P31677 http://www.uniprot.org/uniprot/P31677 charge swissprot:OTSA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:OTSA_ECOLI eggNOG COG0380 http://eggnogapi.embl.de/nog_data/html/tree/COG0380 eggNOG ENOG4105C1K http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C1K epestfind swissprot:OTSA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:OTSA_ECOLI garnier swissprot:OTSA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:OTSA_ECOLI helixturnhelix swissprot:OTSA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:OTSA_ECOLI hmoment swissprot:OTSA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:OTSA_ECOLI iep swissprot:OTSA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:OTSA_ECOLI inforesidue swissprot:OTSA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:OTSA_ECOLI octanol swissprot:OTSA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:OTSA_ECOLI pepcoil swissprot:OTSA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:OTSA_ECOLI pepdigest swissprot:OTSA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:OTSA_ECOLI pepinfo swissprot:OTSA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:OTSA_ECOLI pepnet swissprot:OTSA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:OTSA_ECOLI pepstats swissprot:OTSA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:OTSA_ECOLI pepwheel swissprot:OTSA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:OTSA_ECOLI pepwindow swissprot:OTSA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:OTSA_ECOLI sigcleave swissprot:OTSA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:OTSA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259840 527 # EcoGene EG10125 bolA # FUNCTION BOLA_ECOLI Transcriptional regulator that plays an important role in general stress response. Has many effects on cell morphology, cell growth and cell division. Acts by regulating the transcription of many genes, including dacA (PBP-5), dacC (PBP-6), ampC and mreB. Probably involved in the coordination of genes that adapt the cell physiology in order to enhance cell adaptation and survival under stress conditions. Essential for normal cell morphology in stationary phase and under conditions of starvation (PubMed 10361282, PubMed 12354237, PubMed 19111750, PubMed 21464593, PubMed 25691594). Also regulates a complex network of genes encoding proteins related to biofilm development, and negatively modulates flagellar biosynthesis and swimming capacity. Could be a motile/adhesive transcriptional switch, specifically involved in the transition between the planktonic and the attachment stage of biofilm formation (PubMed 25691594). Overexpression produces round cell shape, impairs cell growth rate and induces biofilm development (PubMed 305364, PubMed 15345459, PubMed 21464593). {ECO 0000269|PubMed 10361282, ECO 0000269|PubMed 12354237, ECO 0000269|PubMed 15345459, ECO 0000269|PubMed 19111750, ECO 0000269|PubMed 21464593, ECO 0000269|PubMed 25691594, ECO 0000269|PubMed 305364}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEP:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.30.300.90 -; 1. # INDUCTION BOLA_ECOLI Induced during the transition to the stationary phase, under the control of the sigma factor RpoS (PubMed 2684651). Also induced during early logarithmic growth in response to several forms of stress (heat shock, acidic stress, oxidative stress, carbon-starvation stress and osmotic shock), and this induction can be partially RpoS independent (PubMed 10361282). {ECO 0000269|PubMed 10361282, ECO 0000269|PubMed 2684651}. # INTERACTION BOLA_ECOLI P0AC69 grxD; NbExp=2; IntAct=EBI-545774, EBI-545828; # IntAct P0ABE2 13 # InterPro IPR002634 BolA # MISCELLANEOUS Was predicted, by combining genome sequences, physical interactions and 3D structures analyses, to be a reductase that interacts with a glutaredoxin. {ECO:0000305|PubMed 15670813}. # Organism BOLA_ECOLI Escherichia coli (strain K12) # PATRIC 32116021 VBIEscCol129921_0452 # PDB 2DHM NMR; -; A=1-100 # PIRSF PIRSF003113 BolA # Pfam PF01722 BolA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DNA-binding transcriptional regulator BolA {ECO 0000305} # RefSeq NP_414969 NC_000913.3 # RefSeq WP_000973448 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB28882.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAB40191.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=CAA35633.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; # SIMILARITY Belongs to the BolA/IbaG family. {ECO 0000305}. # SUPFAM SSF82657 SSF82657 # eggNOG COG0271 LUCA # eggNOG ENOG4105M85 Bacteria BLAST swissprot:BOLA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BOLA_ECOLI BioCyc ECOL316407:JW5060-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5060-MONOMER BioCyc EcoCyc:EG10125-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10125-MONOMER COG COG0271 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0271 DIP DIP-47926N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47926N DOI 10.1016/j.febslet.2004.11.111 http://dx.doi.org/10.1016/j.febslet.2004.11.111 DOI 10.1016/j.jmb.2008.12.026 http://dx.doi.org/10.1016/j.jmb.2008.12.026 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1999.01397.x http://dx.doi.org/10.1046/j.1365-2958.1999.01397.x DOI 10.1046/j.1365-2958.2002.03131.x http://dx.doi.org/10.1046/j.1365-2958.2002.03131.x DOI 10.1111/j.1365-2958.1993.tb01731.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb01731.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AEM.70.9.5682-5684.2004 http://dx.doi.org/10.1128/AEM.70.9.5682-5684.2004 DOI 10.1128/mBio.02352-14 http://dx.doi.org/10.1128/mBio.02352-14 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL S67816 http://www.ebi.ac.uk/ena/data/view/S67816 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL X17642 http://www.ebi.ac.uk/ena/data/view/X17642 EchoBASE EB0123 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0123 EcoGene EG10125 http://www.ecogene.org/geneInfo.php?eg_id=EG10125 EnsemblBacteria AAC73538 http://www.ensemblgenomes.org/id/AAC73538 EnsemblBacteria AAC73538 http://www.ensemblgenomes.org/id/AAC73538 EnsemblBacteria BAE76215 http://www.ensemblgenomes.org/id/BAE76215 EnsemblBacteria BAE76215 http://www.ensemblgenomes.org/id/BAE76215 EnsemblBacteria BAE76215 http://www.ensemblgenomes.org/id/BAE76215 EnsemblBacteria b0435 http://www.ensemblgenomes.org/id/b0435 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.30.300.90 http://www.cathdb.info/version/latest/superfamily/3.30.300.90 GeneID 947043 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947043 HOGENOM HOG000255169 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000255169&db=HOGENOM6 InParanoid P0ABE2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABE2 IntAct P0ABE2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABE2* InterPro IPR002634 http://www.ebi.ac.uk/interpro/entry/IPR002634 KEGG_Gene ecj:JW5060 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5060 KEGG_Gene eco:b0435 http://www.genome.jp/dbget-bin/www_bget?eco:b0435 KEGG_Orthology KO:K05527 http://www.genome.jp/dbget-bin/www_bget?KO:K05527 MINT MINT-1238063 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1238063 OMA INESHNH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=INESHNH PDB 2DHM http://www.ebi.ac.uk/pdbe-srv/view/entry/2DHM PDBsum 2DHM http://www.ebi.ac.uk/pdbsum/2DHM PSORT swissprot:BOLA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BOLA_ECOLI PSORT-B swissprot:BOLA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BOLA_ECOLI PSORT2 swissprot:BOLA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BOLA_ECOLI Pfam PF01722 http://pfam.xfam.org/family/PF01722 Phobius swissprot:BOLA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BOLA_ECOLI PhylomeDB P0ABE2 http://phylomedb.org/?seqid=P0ABE2 ProteinModelPortal P0ABE2 http://www.proteinmodelportal.org/query/uniprot/P0ABE2 PubMed 10361282 http://www.ncbi.nlm.nih.gov/pubmed/10361282 PubMed 12354237 http://www.ncbi.nlm.nih.gov/pubmed/12354237 PubMed 15345459 http://www.ncbi.nlm.nih.gov/pubmed/15345459 PubMed 15670813 http://www.ncbi.nlm.nih.gov/pubmed/15670813 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19111750 http://www.ncbi.nlm.nih.gov/pubmed/19111750 PubMed 21464593 http://www.ncbi.nlm.nih.gov/pubmed/21464593 PubMed 25691594 http://www.ncbi.nlm.nih.gov/pubmed/25691594 PubMed 2684651 http://www.ncbi.nlm.nih.gov/pubmed/2684651 PubMed 305364 http://www.ncbi.nlm.nih.gov/pubmed/305364 PubMed 8231804 http://www.ncbi.nlm.nih.gov/pubmed/8231804 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414969 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414969 RefSeq WP_000973448 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000973448 SMR P0ABE2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABE2 STRING 511145.b0435 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0435&targetmode=cogs STRING COG0271 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0271&targetmode=cogs SUPFAM SSF82657 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF82657 UniProtKB BOLA_ECOLI http://www.uniprot.org/uniprot/BOLA_ECOLI UniProtKB-AC P0ABE2 http://www.uniprot.org/uniprot/P0ABE2 charge swissprot:BOLA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BOLA_ECOLI eggNOG COG0271 http://eggnogapi.embl.de/nog_data/html/tree/COG0271 eggNOG ENOG4105M85 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105M85 epestfind swissprot:BOLA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BOLA_ECOLI garnier swissprot:BOLA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BOLA_ECOLI helixturnhelix swissprot:BOLA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BOLA_ECOLI hmoment swissprot:BOLA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BOLA_ECOLI iep swissprot:BOLA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BOLA_ECOLI inforesidue swissprot:BOLA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BOLA_ECOLI octanol swissprot:BOLA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BOLA_ECOLI pepcoil swissprot:BOLA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BOLA_ECOLI pepdigest swissprot:BOLA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BOLA_ECOLI pepinfo swissprot:BOLA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BOLA_ECOLI pepnet swissprot:BOLA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BOLA_ECOLI pepstats swissprot:BOLA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BOLA_ECOLI pepwheel swissprot:BOLA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BOLA_ECOLI pepwindow swissprot:BOLA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BOLA_ECOLI sigcleave swissprot:BOLA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BOLA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260131 14 # CDD cd01038 Endonuclease_DUF559 # EcoGene EG12653 ycjD # GO_function GO:0004519 endonuclease activity; IEA:InterPro. # GO_process GO:0006298 mismatch repair; IEA:InterPro. # GOslim_function GO:0004518 nuclease activity # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # Gene3D 3.40.960.10 -; 1. # InterPro IPR004603 DNA_mismatch_endonuc_vsr # InterPro IPR007569 DUF559 # InterPro IPR011335 Restrct_endonuc-II-like # Organism YCJD_ECOLI Escherichia coli (strain K12) # PATRIC 32117848 VBIEscCol129921_1344 # PIR D64877 D64877 # Pfam PF04480 DUF559 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCJD_ECOLI Uncharacterized protein YcjD # RefSeq NP_415805 NC_000913.3 # SIMILARITY To H.influenzae HI_1162 and to HI_0925. {ECO 0000305}. # SUPFAM SSF52980 SSF52980 # eggNOG COG2852 LUCA # eggNOG ENOG4105WDY Bacteria BLAST swissprot:YCJD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCJD_ECOLI BioCyc ECOL316407:JW1282-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1282-MONOMER BioCyc EcoCyc:G6641-MONOMER http://biocyc.org/getid?id=EcoCyc:G6641-MONOMER DOI 10.1007/BF00028873 http://dx.doi.org/10.1007/BF00028873 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1099/00221287-138-10-2093 http://dx.doi.org/10.1099/00221287-138-10-2093 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M97219 http://www.ebi.ac.uk/ena/data/view/M97219 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U08190 http://www.ebi.ac.uk/ena/data/view/U08190 EMBL X78733 http://www.ebi.ac.uk/ena/data/view/X78733 EMBL X97282 http://www.ebi.ac.uk/ena/data/view/X97282 EchoBASE EB2523 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2523 EcoGene EG12653 http://www.ecogene.org/geneInfo.php?eg_id=EG12653 EnsemblBacteria AAC74371 http://www.ensemblgenomes.org/id/AAC74371 EnsemblBacteria AAC74371 http://www.ensemblgenomes.org/id/AAC74371 EnsemblBacteria BAA14842 http://www.ensemblgenomes.org/id/BAA14842 EnsemblBacteria BAA14842 http://www.ensemblgenomes.org/id/BAA14842 EnsemblBacteria BAA14842 http://www.ensemblgenomes.org/id/BAA14842 EnsemblBacteria b1289 http://www.ensemblgenomes.org/id/b1289 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004519 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004519 GO_process GO:0006298 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006298 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.40.960.10 http://www.cathdb.info/version/latest/superfamily/3.40.960.10 GeneID 945871 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945871 HOGENOM HOG000218764 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218764&db=HOGENOM6 InParanoid P45736 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45736 InterPro IPR004603 http://www.ebi.ac.uk/interpro/entry/IPR004603 InterPro IPR007569 http://www.ebi.ac.uk/interpro/entry/IPR007569 InterPro IPR011335 http://www.ebi.ac.uk/interpro/entry/IPR011335 KEGG_Gene ecj:JW1282 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1282 KEGG_Gene eco:b1289 http://www.genome.jp/dbget-bin/www_bget?eco:b1289 OMA DFACHAK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DFACHAK PSORT swissprot:YCJD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCJD_ECOLI PSORT-B swissprot:YCJD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCJD_ECOLI PSORT2 swissprot:YCJD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCJD_ECOLI Pfam PF04480 http://pfam.xfam.org/family/PF04480 Phobius swissprot:YCJD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCJD_ECOLI PhylomeDB P45736 http://phylomedb.org/?seqid=P45736 ProteinModelPortal P45736 http://www.proteinmodelportal.org/query/uniprot/P45736 PubMed 1364817 http://www.ncbi.nlm.nih.gov/pubmed/1364817 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8075395 http://www.ncbi.nlm.nih.gov/pubmed/8075395 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415805 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415805 SMR P45736 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45736 STRING 511145.b1289 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1289&targetmode=cogs SUPFAM SSF52980 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52980 UniProtKB YCJD_ECOLI http://www.uniprot.org/uniprot/YCJD_ECOLI UniProtKB-AC P45736 http://www.uniprot.org/uniprot/P45736 charge swissprot:YCJD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCJD_ECOLI eggNOG COG2852 http://eggnogapi.embl.de/nog_data/html/tree/COG2852 eggNOG ENOG4105WDY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105WDY epestfind swissprot:YCJD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCJD_ECOLI garnier swissprot:YCJD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCJD_ECOLI helixturnhelix swissprot:YCJD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCJD_ECOLI hmoment swissprot:YCJD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCJD_ECOLI iep swissprot:YCJD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCJD_ECOLI inforesidue swissprot:YCJD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCJD_ECOLI octanol swissprot:YCJD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCJD_ECOLI pepcoil swissprot:YCJD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCJD_ECOLI pepdigest swissprot:YCJD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCJD_ECOLI pepinfo swissprot:YCJD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCJD_ECOLI pepnet swissprot:YCJD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCJD_ECOLI pepstats swissprot:YCJD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCJD_ECOLI pepwheel swissprot:YCJD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCJD_ECOLI pepwindow swissprot:YCJD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCJD_ECOLI sigcleave swissprot:YCJD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCJD_ECOLI ## Database ID URL or Descriptions # AltName FADL_ECOLI Outer membrane FadL protein # AltName FADL_ECOLI Outer membrane flp protein # BioGrid 4260536 111 # EcoGene EG10280 fadL # FUNCTION FADL_ECOLI Involved in translocation of long-chain fatty acids across the outer membrane. It is a receptor for the bacteriophage T2. FadL may form a specific channel. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015483 long-chain fatty acid transporting porin activity; IDA:EcoCyc. # GO_function GO:0022834 ligand-gated channel activity; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0022857 transmembrane transporter activity # INDUCTION FADL_ECOLI By long-chain fatty acids. Expression of fadL is under the control of the FadR repressor. # InterPro IPR005017 OMPP1/FadL/TodX # KEGG_Brite ko02000 Transporters # Organism FADL_ECOLI Escherichia coli (strain K12) # PATRIC 32120061 VBIEscCol129921_2440 # PDB 1T16 X-ray; 2.60 A; A/B=26-446 # PDB 1T1L X-ray; 2.80 A; A/B=26-446 # PDB 2R4L X-ray; 3.30 A; A/B/C=26-446 # PDB 2R4N X-ray; 3.20 A; A/B=26-446 # PDB 2R4O X-ray; 3.60 A; A/B=26-446 # PDB 2R4P X-ray; 2.90 A; A/B=26-446 # PDB 2R88 X-ray; 2.60 A; A/B=26-446 # PDB 2R89 X-ray; 3.40 A; A/B=31-446 # PDB 2R8A X-ray; 3.00 A; A/B=36-446 # PDB 3DWN X-ray; 2.50 A; A/B=26-446 # PDB 3PF1 X-ray; 2.70 A; A/B=26-446 # PDB 3PGR X-ray; 2.60 A; A=26-446 # PDB 3PGS X-ray; 1.90 A; A/B=26-446 # PDB 3PGU X-ray; 1.70 A; A=26-446 # PIR F65007 F65007 # Pfam PF03349 Toluene_X # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FADL_ECOLI Long-chain fatty acid transport protein # RefSeq NP_416846 NC_000913.3 # RefSeq WP_001295701 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA64433.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA16205.1; Type=Erroneous initiation; Evidence={ECO 0000305}; Sequence=CAA68630.1; Type=Erroneous initiation; Evidence={ECO:0000305}; # SIMILARITY Belongs to the OmpP1/FadL family. {ECO 0000305}. # SUBCELLULAR LOCATION FADL_ECOLI Cell outer membrane {ECO 0000269|PubMed 16079137}; Multi-pass membrane protein {ECO 0000269|PubMed 16079137}. # SUBUNIT FADL_ECOLI Has been isolated from outer membrane preparation as a homodimer. # TCDB 1.B.9.1 the fadl outer membrane protein (fadl) family # eggNOG COG2067 LUCA # eggNOG ENOG4105CKF Bacteria BLAST swissprot:FADL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FADL_ECOLI BioCyc ECOL316407:JW2341-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2341-MONOMER BioCyc EcoCyc:EG10280-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10280-MONOMER BioCyc MetaCyc:EG10280-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10280-MONOMER COG COG2067 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2067 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1365-2958.1988.tb00040.x http://dx.doi.org/10.1111/j.1365-2958.1988.tb00040.x DOI 10.1126/science.1097524 http://dx.doi.org/10.1126/science.1097524 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M60607 http://www.ebi.ac.uk/ena/data/view/M60607 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL Y00552 http://www.ebi.ac.uk/ena/data/view/Y00552 EchoBASE EB0276 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0276 EcoGene EG10280 http://www.ecogene.org/geneInfo.php?eg_id=EG10280 EnsemblBacteria AAC75404 http://www.ensemblgenomes.org/id/AAC75404 EnsemblBacteria AAC75404 http://www.ensemblgenomes.org/id/AAC75404 EnsemblBacteria BAA16205 http://www.ensemblgenomes.org/id/BAA16205 EnsemblBacteria BAA16205 http://www.ensemblgenomes.org/id/BAA16205 EnsemblBacteria BAA16205 http://www.ensemblgenomes.org/id/BAA16205 EnsemblBacteria b2344 http://www.ensemblgenomes.org/id/b2344 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015483 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015483 GO_function GO:0022834 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022834 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GeneID 946820 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946820 HOGENOM HOG000277333 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000277333&db=HOGENOM6 InParanoid P10384 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P10384 InterPro IPR005017 http://www.ebi.ac.uk/interpro/entry/IPR005017 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2341 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2341 KEGG_Gene eco:b2344 http://www.genome.jp/dbget-bin/www_bget?eco:b2344 KEGG_Orthology KO:K06076 http://www.genome.jp/dbget-bin/www_bget?KO:K06076 OMA NRYGFTY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NRYGFTY PDB 1T16 http://www.ebi.ac.uk/pdbe-srv/view/entry/1T16 PDB 1T1L http://www.ebi.ac.uk/pdbe-srv/view/entry/1T1L PDB 2R4L http://www.ebi.ac.uk/pdbe-srv/view/entry/2R4L PDB 2R4N http://www.ebi.ac.uk/pdbe-srv/view/entry/2R4N PDB 2R4O http://www.ebi.ac.uk/pdbe-srv/view/entry/2R4O PDB 2R4P http://www.ebi.ac.uk/pdbe-srv/view/entry/2R4P PDB 2R88 http://www.ebi.ac.uk/pdbe-srv/view/entry/2R88 PDB 2R89 http://www.ebi.ac.uk/pdbe-srv/view/entry/2R89 PDB 2R8A http://www.ebi.ac.uk/pdbe-srv/view/entry/2R8A PDB 3DWN http://www.ebi.ac.uk/pdbe-srv/view/entry/3DWN PDB 3PF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3PF1 PDB 3PGR http://www.ebi.ac.uk/pdbe-srv/view/entry/3PGR PDB 3PGS http://www.ebi.ac.uk/pdbe-srv/view/entry/3PGS PDB 3PGU http://www.ebi.ac.uk/pdbe-srv/view/entry/3PGU PDBsum 1T16 http://www.ebi.ac.uk/pdbsum/1T16 PDBsum 1T1L http://www.ebi.ac.uk/pdbsum/1T1L PDBsum 2R4L http://www.ebi.ac.uk/pdbsum/2R4L PDBsum 2R4N http://www.ebi.ac.uk/pdbsum/2R4N PDBsum 2R4O http://www.ebi.ac.uk/pdbsum/2R4O PDBsum 2R4P http://www.ebi.ac.uk/pdbsum/2R4P PDBsum 2R88 http://www.ebi.ac.uk/pdbsum/2R88 PDBsum 2R89 http://www.ebi.ac.uk/pdbsum/2R89 PDBsum 2R8A http://www.ebi.ac.uk/pdbsum/2R8A PDBsum 3DWN http://www.ebi.ac.uk/pdbsum/3DWN PDBsum 3PF1 http://www.ebi.ac.uk/pdbsum/3PF1 PDBsum 3PGR http://www.ebi.ac.uk/pdbsum/3PGR PDBsum 3PGS http://www.ebi.ac.uk/pdbsum/3PGS PDBsum 3PGU http://www.ebi.ac.uk/pdbsum/3PGU PSORT swissprot:FADL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FADL_ECOLI PSORT-B swissprot:FADL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FADL_ECOLI PSORT2 swissprot:FADL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FADL_ECOLI Pfam PF03349 http://pfam.xfam.org/family/PF03349 Phobius swissprot:FADL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FADL_ECOLI PhylomeDB P10384 http://phylomedb.org/?seqid=P10384 ProteinModelPortal P10384 http://www.proteinmodelportal.org/query/uniprot/P10384 PubMed 15178802 http://www.ncbi.nlm.nih.gov/pubmed/15178802 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1987139 http://www.ncbi.nlm.nih.gov/pubmed/1987139 PubMed 2840553 http://www.ncbi.nlm.nih.gov/pubmed/2840553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416846 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416846 RefSeq WP_001295701 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295701 SMR P10384 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P10384 STRING 511145.b2344 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2344&targetmode=cogs STRING COG2067 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2067&targetmode=cogs TCDB 1.B.9.1 http://www.tcdb.org/search/result.php?tc=1.B.9.1 UniProtKB FADL_ECOLI http://www.uniprot.org/uniprot/FADL_ECOLI UniProtKB-AC P10384 http://www.uniprot.org/uniprot/P10384 charge swissprot:FADL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FADL_ECOLI eggNOG COG2067 http://eggnogapi.embl.de/nog_data/html/tree/COG2067 eggNOG ENOG4105CKF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CKF epestfind swissprot:FADL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FADL_ECOLI garnier swissprot:FADL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FADL_ECOLI helixturnhelix swissprot:FADL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FADL_ECOLI hmoment swissprot:FADL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FADL_ECOLI iep swissprot:FADL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FADL_ECOLI inforesidue swissprot:FADL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FADL_ECOLI octanol swissprot:FADL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FADL_ECOLI pepcoil swissprot:FADL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FADL_ECOLI pepdigest swissprot:FADL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FADL_ECOLI pepinfo swissprot:FADL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FADL_ECOLI pepnet swissprot:FADL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FADL_ECOLI pepstats swissprot:FADL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FADL_ECOLI pepwheel swissprot:FADL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FADL_ECOLI pepwindow swissprot:FADL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FADL_ECOLI sigcleave swissprot:FADL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FADL_ECOLI ## Database ID URL or Descriptions # AltName ILVH_ECOLI ALS-III # AltName ILVH_ECOLI Acetohydroxy-acid synthase III small subunit # BioGrid 4259381 5 # CATALYTIC ACTIVITY ILVH_ECOLI 2 pyruvate = 2-acetolactate + CO(2). # ENZYME REGULATION ILVH_ECOLI Sensitive to valine inhibition. # EcoGene EG10499 ilvH # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005948 acetolactate synthase complex; IBA:GO_Central. # GO_function GO:0003984 acetolactate synthase activity; IDA:EcoCyc. # GO_function GO:0016597 amino acid binding; IEA:InterPro. # GO_process GO:0009097 isoleucine biosynthetic process; IDA:EcoCyc. # GO_process GO:0009099 valine biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # InterPro IPR002912 ACT_dom # InterPro IPR004789 Acetalactate_synth_ssu # InterPro IPR019455 Acetolactate_synth_ssu_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00290 Valine, leucine and isoleucine biosynthesis # KEGG_Pathway ko00650 Butanoate metabolism # KEGG_Pathway ko00660 C5-Branched dibasic acid metabolism # KEGG_Pathway ko00770 Pantothenate and CoA biosynthesis # MISCELLANEOUS E.coli contains genes for 3 AHAS isozymes ilvBN, ilvGM and ilvIH. # Organism ILVH_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-isoleucine biosynthesis; L- isoleucine from 2-oxobutanoate step 1/4. # PATHWAY Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate step 1/4. # PATRIC 32115259 VBIEscCol129921_0081 # PDB 2F1F X-ray; 1.75 A; A/B=1-163 # PIR F64729 YCEC3H # PROSITE PS51671 ACT # Pfam PF10369 ALS_ss_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ILVH_ECOLI Acetolactate synthase isozyme 3 small subunit # RefSeq NP_414620 NC_000913.3 # RefSeq WP_001300383 NZ_LN832404.1 # SIMILARITY Belongs to the acetolactate synthase small subunit family. {ECO 0000305}. # SIMILARITY Contains 1 ACT domain. {ECO:0000255|PROSITE- ProRule PRU01007}. # SUBUNIT ILVH_ECOLI Dimer of large and small chains. # TIGRFAMs TIGR00119 acolac_sm # UniPathway UPA00047 UER00055 # UniPathway UPA00049 UER00059 # eggNOG COG0440 LUCA # eggNOG ENOG4108ZP8 Bacteria BLAST swissprot:ILVH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ILVH_ECOLI BioCyc ECOL316407:JW0077-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0077-MONOMER BioCyc EcoCyc:ACETOLACTSYNIII-HCHAIN-MONOMER http://biocyc.org/getid?id=EcoCyc:ACETOLACTSYNIII-HCHAIN-MONOMER BioCyc MetaCyc:ACETOLACTSYNIII-HCHAIN-MONOMER http://biocyc.org/getid?id=MetaCyc:ACETOLACTSYNIII-HCHAIN-MONOMER COG COG0440 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0440 DIP DIP-10024N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10024N DOI 10.1007/BF00273623 http://dx.doi.org/10.1007/BF00273623 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/11.15.5299 http://dx.doi.org/10.1093/nar/11.15.5299 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.2.1.6 http://www.genome.jp/dbget-bin/www_bget?EC:2.2.1.6 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M35034 http://www.ebi.ac.uk/ena/data/view/M35034 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X01609 http://www.ebi.ac.uk/ena/data/view/X01609 EMBL X55034 http://www.ebi.ac.uk/ena/data/view/X55034 EMBL X55457 http://www.ebi.ac.uk/ena/data/view/X55457 ENZYME 2.2.1.6 http://enzyme.expasy.org/EC/2.2.1.6 EchoBASE EB0494 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0494 EcoGene EG10499 http://www.ecogene.org/geneInfo.php?eg_id=EG10499 EnsemblBacteria AAC73189 http://www.ensemblgenomes.org/id/AAC73189 EnsemblBacteria AAC73189 http://www.ensemblgenomes.org/id/AAC73189 EnsemblBacteria BAB96647 http://www.ensemblgenomes.org/id/BAB96647 EnsemblBacteria BAB96647 http://www.ensemblgenomes.org/id/BAB96647 EnsemblBacteria BAB96647 http://www.ensemblgenomes.org/id/BAB96647 EnsemblBacteria b0078 http://www.ensemblgenomes.org/id/b0078 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005948 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005948 GO_function GO:0003984 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003984 GO_function GO:0016597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016597 GO_process GO:0009097 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009097 GO_process GO:0009099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009099 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 947267 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947267 HOGENOM HOG000046747 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000046747&db=HOGENOM6 InParanoid P00894 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00894 IntAct P00894 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00894* IntEnz 2.2.1.6 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.2.1.6 InterPro IPR002912 http://www.ebi.ac.uk/interpro/entry/IPR002912 InterPro IPR004789 http://www.ebi.ac.uk/interpro/entry/IPR004789 InterPro IPR019455 http://www.ebi.ac.uk/interpro/entry/IPR019455 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0077 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0077 KEGG_Gene eco:b0078 http://www.genome.jp/dbget-bin/www_bget?eco:b0078 KEGG_Orthology KO:K01653 http://www.genome.jp/dbget-bin/www_bget?KO:K01653 KEGG_Pathway ko00290 http://www.genome.jp/kegg-bin/show_pathway?ko00290 KEGG_Pathway ko00650 http://www.genome.jp/kegg-bin/show_pathway?ko00650 KEGG_Pathway ko00660 http://www.genome.jp/kegg-bin/show_pathway?ko00660 KEGG_Pathway ko00770 http://www.genome.jp/kegg-bin/show_pathway?ko00770 KEGG_Reaction rn:R00006 http://www.genome.jp/dbget-bin/www_bget?rn:R00006 KEGG_Reaction rn:R00014 http://www.genome.jp/dbget-bin/www_bget?rn:R00014 KEGG_Reaction rn:R00226 http://www.genome.jp/dbget-bin/www_bget?rn:R00226 KEGG_Reaction rn:R03050 http://www.genome.jp/dbget-bin/www_bget?rn:R03050 KEGG_Reaction rn:R04672 http://www.genome.jp/dbget-bin/www_bget?rn:R04672 KEGG_Reaction rn:R04673 http://www.genome.jp/dbget-bin/www_bget?rn:R04673 OMA PYGIREI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PYGIREI PDB 2F1F http://www.ebi.ac.uk/pdbe-srv/view/entry/2F1F PDBsum 2F1F http://www.ebi.ac.uk/pdbsum/2F1F PROSITE PS51671 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51671 PSORT swissprot:ILVH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ILVH_ECOLI PSORT-B swissprot:ILVH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ILVH_ECOLI PSORT2 swissprot:ILVH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ILVH_ECOLI Pfam PF10369 http://pfam.xfam.org/family/PF10369 Phobius swissprot:ILVH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ILVH_ECOLI PhylomeDB P00894 http://phylomedb.org/?seqid=P00894 ProteinModelPortal P00894 http://www.proteinmodelportal.org/query/uniprot/P00894 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1851954 http://www.ncbi.nlm.nih.gov/pubmed/1851954 PubMed 2198273 http://www.ncbi.nlm.nih.gov/pubmed/2198273 PubMed 6308579 http://www.ncbi.nlm.nih.gov/pubmed/6308579 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414620 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414620 RefSeq WP_001300383 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300383 SMR P00894 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00894 STRING 511145.b0078 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0078&targetmode=cogs STRING COG0440 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0440&targetmode=cogs SWISS-2DPAGE P00894 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P00894 TIGRFAMs TIGR00119 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00119 UniProtKB ILVH_ECOLI http://www.uniprot.org/uniprot/ILVH_ECOLI UniProtKB-AC P00894 http://www.uniprot.org/uniprot/P00894 charge swissprot:ILVH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ILVH_ECOLI eggNOG COG0440 http://eggnogapi.embl.de/nog_data/html/tree/COG0440 eggNOG ENOG4108ZP8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZP8 epestfind swissprot:ILVH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ILVH_ECOLI garnier swissprot:ILVH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ILVH_ECOLI helixturnhelix swissprot:ILVH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ILVH_ECOLI hmoment swissprot:ILVH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ILVH_ECOLI iep swissprot:ILVH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ILVH_ECOLI inforesidue swissprot:ILVH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ILVH_ECOLI octanol swissprot:ILVH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ILVH_ECOLI pepcoil swissprot:ILVH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ILVH_ECOLI pepdigest swissprot:ILVH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ILVH_ECOLI pepinfo swissprot:ILVH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ILVH_ECOLI pepnet swissprot:ILVH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ILVH_ECOLI pepstats swissprot:ILVH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ILVH_ECOLI pepwheel swissprot:ILVH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ILVH_ECOLI pepwindow swissprot:ILVH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ILVH_ECOLI sigcleave swissprot:ILVH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ILVH_ECOLI ## Database ID URL or Descriptions # AltName ACRB_ECOLI AcrAB-TolC multidrug efflux pump subunit AcrB # AltName ACRB_ECOLI Acridine resistance protein B # BioGrid 4259859 350 # DISRUPTION PHENOTYPE Loss of susceptibility to contact-dependent growth inhibition (CDI); inhibiting cells still contact the target. {ECO:0000269|PubMed 18761695}. # EcoGene EG11704 acrB # FUNCTION ACRB_ECOLI AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. {ECO 0000269|PubMed 16915237, ECO 0000269|PubMed 16946072, ECO 0000269|PubMed 17194213, ECO 0000269|PubMed 23010927}. # FUNCTION ACRB_ECOLI Involved in contact-dependent growth inhibition (CDI), acts downstream of BamA, the receptor for CDI. Its role in CDI is independent of the AcrA-AcrB-TolC efflux pump complex. {ECO 0000269|PubMed 18761695}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function ACRB_ECOLI GO 0015307 drug proton antiporter activity; IDA EcoCyc. # GO_function GO:0015238 drug transmembrane transporter activity; IMP:EcoCyc. # GO_function GO:0042802 identical protein binding; IPI:IntAct. # GO_process GO:0006855 drug transmembrane transport; IMP:EcoCyc. # GO_process GO:0042493 response to drug; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0055085 transmembrane transport # Gene3D 3.30.2090.10 -; 2. # INDUCTION Positively regulated by MarA, Rob and SoxS transcriptional regulators (at protein level). {ECO:0000269|PubMed 23010927}. # INTERACTION ACRB_ECOLI Self; NbExp=4; IntAct=EBI-551006, EBI-551006; P0AAW9 acrZ; NbExp=4; IntAct=EBI-551006, EBI-6313593; # IntAct P31224 8 # InterPro IPR001036 Acrflvin-R # InterPro IPR004764 HAE1 # InterPro IPR027463 AcrB_DN_DC_subdom # Organism ACRB_ECOLI Escherichia coli (strain K12) # PATRIC 32116077 VBIEscCol129921_0480 # PDB 1IWG X-ray; 3.50 A; A=1-1049 # PDB 1OY6 X-ray; 3.68 A; A=1-1049 # PDB 1OY8 X-ray; 3.63 A; A=1-1049 # PDB 1OY9 X-ray; 3.80 A; A=1-1049 # PDB 1OYD X-ray; 3.80 A; A=1-1049 # PDB 1OYE X-ray; 3.48 A; A=1-1049 # PDB 1T9T X-ray; 3.23 A; A=1-1049 # PDB 1T9U X-ray; 3.11 A; A=1-1049 # PDB 1T9V X-ray; 3.80 A; A=1-1049 # PDB 1T9W X-ray; 3.23 A; A=1-1049 # PDB 1T9X X-ray; 3.08 A; A=1-1049 # PDB 1T9Y X-ray; 3.64 A; A=1-1049 # PDB 2DHH X-ray; 2.80 A; A/B/C=1-1049 # PDB 2DR6 X-ray; 3.30 A; A/B/C=1-1049 # PDB 2DRD X-ray; 3.10 A; A/B/C=1-1049 # PDB 2GIF X-ray; 2.90 A; A/B/C=1-1049 # PDB 2HQC X-ray; 3.56 A; A=1-1049 # PDB 2HQD X-ray; 3.65 A; A=1-1049 # PDB 2HQF X-ray; 3.38 A; A=1-1049 # PDB 2HQG X-ray; 3.38 A; A=1-1049 # PDB 2HRT X-ray; 3.00 A; A/B/C/D/E/F=1-1049 # PDB 2I6W X-ray; 3.10 A; A=1-1049 # PDB 2J8S X-ray; 2.54 A; A/B/C=1-1049 # PDB 2RDD X-ray; 3.50 A; A=1-1036 # PDB 2W1B X-ray; 3.85 A; A=1-1049 # PDB 3AOA X-ray; 3.35 A; A/B/C=1-1049 # PDB 3AOB X-ray; 3.35 A; A/B/C=1-1049 # PDB 3AOC X-ray; 3.34 A; A/B/C=1-1049 # PDB 3AOD X-ray; 3.30 A; A/B/C=1-1049 # PDB 3D9B X-ray; 3.42 A; A=1-1049 # PDB 3NOC X-ray; 2.70 A; A/B/C=1-1049 # PDB 3NOG X-ray; 3.34 A; A/B/C=1-1049 # PDB 3W9H X-ray; 3.05 A; A/B/C=1-1033 # PDB 4C48 X-ray; 3.30 A; A=1-1047 # PDB 4CDI X-ray; 3.70 A; A=1-1049 # PDB 4DX5 X-ray; 1.90 A; A/B/C=1-1049 # PDB 4DX6 X-ray; 2.90 A; A/B/C=1-1049 # PDB 4DX7 X-ray; 2.25 A; A/B/C=1-1049 # PDB 4K7Q X-ray; 3.50 A; A=1-1049 # PDB 4U8V X-ray; 2.30 A; A/B/C=1-1049 # PDB 4U8Y X-ray; 2.10 A; A/B/C=1-1049 # PDB 4U95 X-ray; 2.00 A; A/B/C=1-1049 # PDB 4U96 X-ray; 2.20 A; A/B/C=1-1049 # PDB 4ZIT X-ray; 3.30 A; A/B/C/D/E/F=1-1049 # PDB 4ZIV X-ray; 3.16 A; A/B/C/D/E/F=1-1049 # PDB 4ZIW X-ray; 3.40 A; A/B/C/D/E/F=1-1049 # PDB 4ZJL X-ray; 3.47 A; A/B/C/D/E/F=1-1049 # PDB 4ZJO X-ray; 3.60 A; A/B/C/D/E/F=1-1049 # PDB 4ZJQ X-ray; 3.59 A; A/B/C/D/E/F=1-1049 # PDB 4ZLJ X-ray; 3.26 A; A=1-1049 # PDB 4ZLL X-ray; 3.36 A; A=1-1049 # PDB 4ZLN X-ray; 3.56 A; A=1-1049 # PDB 5EN5 X-ray; 2.30 A; A/B/C=39-329, A/B/C=561-869 # PDB 5ENO X-ray; 2.20 A; A/B/C=39-329, A/B/C=561-869 # PDB 5ENP X-ray; 1.90 A; A/B/C=39-329, A/B/C=561-869 # PDB 5ENQ X-ray; 1.80 A; A/B/C=39-329, A/B/C=561-869 # PDB 5ENR X-ray; 2.30 A; A/B/C=39-329, A/B/C=561-869 # PDB 5ENS X-ray; 2.80 A; A/B/C=39-329, A/B/C=561-869 # PDB 5ENT X-ray; 2.50 A; A/B/C=39-329, A/B/C=561-869 # PIR B36938 B36938 # PRINTS PR00702 ACRIFLAVINRP # Pfam PF00873 ACR_tran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ACRB_ECOLI Multidrug efflux pump subunit AcrB # RefSeq NP_414995 NC_000913.3 # RefSeq WP_001132469 NZ_LN832404.1 # SIMILARITY Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. {ECO 0000305}. # SUBCELLULAR LOCATION ACRB_ECOLI Cell inner membrane {ECO 0000269|PubMed 15228545, ECO 0000269|PubMed 16079137}; Multi- pass membrane protein {ECO 0000269|PubMed 15228545, ECO 0000269|PubMed 16079137}. # SUBUNIT ACRB_ECOLI Homotrimer, with large domains that extend into the periplasm, interacts with AcrA and TolC. AcrA may be required to stably link this protein and TolC. Interacts with AcrZ. Part of the AcrA-AcrB-AcrZ-TolC efflux pump. {ECO 0000269|PubMed 10920254, ECO 0000269|PubMed 12374972, ECO 0000269|PubMed 12738864, ECO 0000269|PubMed 15228545, ECO 0000269|PubMed 16079137, ECO 0000269|PubMed 16915237, ECO 0000269|PubMed 16946072, ECO 0000269|PubMed 17194213, ECO 0000269|PubMed 23010927}. # SUPFAM SSF82714 SSF82714; 2 # TCDB 2.A.6.2 the resistance-nodulation-cell division (rnd) superfamily # TIGRFAMs TIGR00915 2A0602 # eggNOG COG0841 LUCA # eggNOG ENOG4105BZS Bacteria BLAST swissprot:ACRB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ACRB_ECOLI BioCyc ECOL316407:JW0451-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0451-MONOMER BioCyc EcoCyc:ACRB-MONOMER http://biocyc.org/getid?id=EcoCyc:ACRB-MONOMER COG COG0841 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0841 DIP DIP-9049N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9049N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature01050 http://dx.doi.org/10.1038/nature01050 DOI 10.1038/nature05076 http://dx.doi.org/10.1038/nature05076 DOI 10.1073/pnas.1210093109 http://dx.doi.org/10.1073/pnas.1210093109 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1093/oxfordjournals.jbchem.a022741 http://dx.doi.org/10.1093/oxfordjournals.jbchem.a022741 DOI 10.1111/j.1365-2958.1995.tb02390.x http://dx.doi.org/10.1111/j.1365-2958.1995.tb02390.x DOI 10.1111/j.1365-2958.2004.04158.x http://dx.doi.org/10.1111/j.1365-2958.2004.04158.x DOI 10.1111/j.1365-2958.2008.06404.x http://dx.doi.org/10.1111/j.1365-2958.2008.06404.x DOI 10.1126/science.1083137 http://dx.doi.org/10.1126/science.1083137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.1131542 http://dx.doi.org/10.1126/science.1131542 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pbio.0050007 http://dx.doi.org/10.1371/journal.pbio.0050007 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M94248 http://www.ebi.ac.uk/ena/data/view/M94248 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U00734 http://www.ebi.ac.uk/ena/data/view/U00734 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EchoBASE EB1655 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1655 EcoGene EG11704 http://www.ecogene.org/geneInfo.php?eg_id=EG11704 EnsemblBacteria AAC73564 http://www.ensemblgenomes.org/id/AAC73564 EnsemblBacteria AAC73564 http://www.ensemblgenomes.org/id/AAC73564 EnsemblBacteria BAE76241 http://www.ensemblgenomes.org/id/BAE76241 EnsemblBacteria BAE76241 http://www.ensemblgenomes.org/id/BAE76241 EnsemblBacteria BAE76241 http://www.ensemblgenomes.org/id/BAE76241 EnsemblBacteria b0462 http://www.ensemblgenomes.org/id/b0462 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0015238 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015238 GO_function GO:0015307 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015307 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0006855 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006855 GO_process GO:0042493 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 3.30.2090.10 http://www.cathdb.info/version/latest/superfamily/3.30.2090.10 GeneID 945108 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945108 HOGENOM HOG000158129 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000158129&db=HOGENOM6 InParanoid P31224 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31224 IntAct P31224 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31224* InterPro IPR001036 http://www.ebi.ac.uk/interpro/entry/IPR001036 InterPro IPR004764 http://www.ebi.ac.uk/interpro/entry/IPR004764 InterPro IPR027463 http://www.ebi.ac.uk/interpro/entry/IPR027463 KEGG_Gene ecj:JW0451 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0451 KEGG_Gene eco:b0462 http://www.genome.jp/dbget-bin/www_bget?eco:b0462 KEGG_Orthology KO:K03296 http://www.genome.jp/dbget-bin/www_bget?KO:K03296 MINT MINT-1286285 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1286285 OMA KNFLMVI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KNFLMVI PDB 1IWG http://www.ebi.ac.uk/pdbe-srv/view/entry/1IWG PDB 1OY6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1OY6 PDB 1OY8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1OY8 PDB 1OY9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1OY9 PDB 1OYD http://www.ebi.ac.uk/pdbe-srv/view/entry/1OYD PDB 1OYE http://www.ebi.ac.uk/pdbe-srv/view/entry/1OYE PDB 1T9T http://www.ebi.ac.uk/pdbe-srv/view/entry/1T9T PDB 1T9U http://www.ebi.ac.uk/pdbe-srv/view/entry/1T9U PDB 1T9V http://www.ebi.ac.uk/pdbe-srv/view/entry/1T9V PDB 1T9W http://www.ebi.ac.uk/pdbe-srv/view/entry/1T9W PDB 1T9X http://www.ebi.ac.uk/pdbe-srv/view/entry/1T9X PDB 1T9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/1T9Y PDB 2DHH http://www.ebi.ac.uk/pdbe-srv/view/entry/2DHH PDB 2DR6 http://www.ebi.ac.uk/pdbe-srv/view/entry/2DR6 PDB 2DRD http://www.ebi.ac.uk/pdbe-srv/view/entry/2DRD PDB 2GIF http://www.ebi.ac.uk/pdbe-srv/view/entry/2GIF PDB 2HQC http://www.ebi.ac.uk/pdbe-srv/view/entry/2HQC PDB 2HQD http://www.ebi.ac.uk/pdbe-srv/view/entry/2HQD PDB 2HQF http://www.ebi.ac.uk/pdbe-srv/view/entry/2HQF PDB 2HQG http://www.ebi.ac.uk/pdbe-srv/view/entry/2HQG PDB 2HRT http://www.ebi.ac.uk/pdbe-srv/view/entry/2HRT PDB 2I6W http://www.ebi.ac.uk/pdbe-srv/view/entry/2I6W PDB 2J8S http://www.ebi.ac.uk/pdbe-srv/view/entry/2J8S PDB 2RDD http://www.ebi.ac.uk/pdbe-srv/view/entry/2RDD PDB 2W1B http://www.ebi.ac.uk/pdbe-srv/view/entry/2W1B PDB 3AOA http://www.ebi.ac.uk/pdbe-srv/view/entry/3AOA PDB 3AOB http://www.ebi.ac.uk/pdbe-srv/view/entry/3AOB PDB 3AOC http://www.ebi.ac.uk/pdbe-srv/view/entry/3AOC PDB 3AOD http://www.ebi.ac.uk/pdbe-srv/view/entry/3AOD PDB 3D9B http://www.ebi.ac.uk/pdbe-srv/view/entry/3D9B PDB 3NOC http://www.ebi.ac.uk/pdbe-srv/view/entry/3NOC PDB 3NOG http://www.ebi.ac.uk/pdbe-srv/view/entry/3NOG PDB 3W9H http://www.ebi.ac.uk/pdbe-srv/view/entry/3W9H PDB 4C48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4C48 PDB 4CDI http://www.ebi.ac.uk/pdbe-srv/view/entry/4CDI PDB 4DX5 http://www.ebi.ac.uk/pdbe-srv/view/entry/4DX5 PDB 4DX6 http://www.ebi.ac.uk/pdbe-srv/view/entry/4DX6 PDB 4DX7 http://www.ebi.ac.uk/pdbe-srv/view/entry/4DX7 PDB 4K7Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4K7Q PDB 4U8V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U8V PDB 4U8Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4U8Y PDB 4U95 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U95 PDB 4U96 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U96 PDB 4ZIT http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZIT PDB 4ZIV http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZIV PDB 4ZIW http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZIW PDB 4ZJL http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZJL PDB 4ZJO http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZJO PDB 4ZJQ http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZJQ PDB 4ZLJ http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZLJ PDB 4ZLL http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZLL PDB 4ZLN http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZLN PDB 5EN5 http://www.ebi.ac.uk/pdbe-srv/view/entry/5EN5 PDB 5ENO http://www.ebi.ac.uk/pdbe-srv/view/entry/5ENO PDB 5ENP http://www.ebi.ac.uk/pdbe-srv/view/entry/5ENP PDB 5ENQ http://www.ebi.ac.uk/pdbe-srv/view/entry/5ENQ PDB 5ENR http://www.ebi.ac.uk/pdbe-srv/view/entry/5ENR PDB 5ENS http://www.ebi.ac.uk/pdbe-srv/view/entry/5ENS PDB 5ENT http://www.ebi.ac.uk/pdbe-srv/view/entry/5ENT PDBsum 1IWG http://www.ebi.ac.uk/pdbsum/1IWG PDBsum 1OY6 http://www.ebi.ac.uk/pdbsum/1OY6 PDBsum 1OY8 http://www.ebi.ac.uk/pdbsum/1OY8 PDBsum 1OY9 http://www.ebi.ac.uk/pdbsum/1OY9 PDBsum 1OYD http://www.ebi.ac.uk/pdbsum/1OYD PDBsum 1OYE http://www.ebi.ac.uk/pdbsum/1OYE PDBsum 1T9T http://www.ebi.ac.uk/pdbsum/1T9T PDBsum 1T9U http://www.ebi.ac.uk/pdbsum/1T9U PDBsum 1T9V http://www.ebi.ac.uk/pdbsum/1T9V PDBsum 1T9W http://www.ebi.ac.uk/pdbsum/1T9W PDBsum 1T9X http://www.ebi.ac.uk/pdbsum/1T9X PDBsum 1T9Y http://www.ebi.ac.uk/pdbsum/1T9Y PDBsum 2DHH http://www.ebi.ac.uk/pdbsum/2DHH PDBsum 2DR6 http://www.ebi.ac.uk/pdbsum/2DR6 PDBsum 2DRD http://www.ebi.ac.uk/pdbsum/2DRD PDBsum 2GIF http://www.ebi.ac.uk/pdbsum/2GIF PDBsum 2HQC http://www.ebi.ac.uk/pdbsum/2HQC PDBsum 2HQD http://www.ebi.ac.uk/pdbsum/2HQD PDBsum 2HQF http://www.ebi.ac.uk/pdbsum/2HQF PDBsum 2HQG http://www.ebi.ac.uk/pdbsum/2HQG PDBsum 2HRT http://www.ebi.ac.uk/pdbsum/2HRT PDBsum 2I6W http://www.ebi.ac.uk/pdbsum/2I6W PDBsum 2J8S http://www.ebi.ac.uk/pdbsum/2J8S PDBsum 2RDD http://www.ebi.ac.uk/pdbsum/2RDD PDBsum 2W1B http://www.ebi.ac.uk/pdbsum/2W1B PDBsum 3AOA http://www.ebi.ac.uk/pdbsum/3AOA PDBsum 3AOB http://www.ebi.ac.uk/pdbsum/3AOB PDBsum 3AOC http://www.ebi.ac.uk/pdbsum/3AOC PDBsum 3AOD http://www.ebi.ac.uk/pdbsum/3AOD PDBsum 3D9B http://www.ebi.ac.uk/pdbsum/3D9B PDBsum 3NOC http://www.ebi.ac.uk/pdbsum/3NOC PDBsum 3NOG http://www.ebi.ac.uk/pdbsum/3NOG PDBsum 3W9H http://www.ebi.ac.uk/pdbsum/3W9H PDBsum 4C48 http://www.ebi.ac.uk/pdbsum/4C48 PDBsum 4CDI http://www.ebi.ac.uk/pdbsum/4CDI PDBsum 4DX5 http://www.ebi.ac.uk/pdbsum/4DX5 PDBsum 4DX6 http://www.ebi.ac.uk/pdbsum/4DX6 PDBsum 4DX7 http://www.ebi.ac.uk/pdbsum/4DX7 PDBsum 4K7Q http://www.ebi.ac.uk/pdbsum/4K7Q PDBsum 4U8V http://www.ebi.ac.uk/pdbsum/4U8V PDBsum 4U8Y http://www.ebi.ac.uk/pdbsum/4U8Y PDBsum 4U95 http://www.ebi.ac.uk/pdbsum/4U95 PDBsum 4U96 http://www.ebi.ac.uk/pdbsum/4U96 PDBsum 4ZIT http://www.ebi.ac.uk/pdbsum/4ZIT PDBsum 4ZIV http://www.ebi.ac.uk/pdbsum/4ZIV PDBsum 4ZIW http://www.ebi.ac.uk/pdbsum/4ZIW PDBsum 4ZJL http://www.ebi.ac.uk/pdbsum/4ZJL PDBsum 4ZJO http://www.ebi.ac.uk/pdbsum/4ZJO PDBsum 4ZJQ http://www.ebi.ac.uk/pdbsum/4ZJQ PDBsum 4ZLJ http://www.ebi.ac.uk/pdbsum/4ZLJ PDBsum 4ZLL http://www.ebi.ac.uk/pdbsum/4ZLL PDBsum 4ZLN http://www.ebi.ac.uk/pdbsum/4ZLN PDBsum 5EN5 http://www.ebi.ac.uk/pdbsum/5EN5 PDBsum 5ENO http://www.ebi.ac.uk/pdbsum/5ENO PDBsum 5ENP http://www.ebi.ac.uk/pdbsum/5ENP PDBsum 5ENQ http://www.ebi.ac.uk/pdbsum/5ENQ PDBsum 5ENR http://www.ebi.ac.uk/pdbsum/5ENR PDBsum 5ENS http://www.ebi.ac.uk/pdbsum/5ENS PDBsum 5ENT http://www.ebi.ac.uk/pdbsum/5ENT PRINTS PR00702 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00702 PSORT swissprot:ACRB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ACRB_ECOLI PSORT-B swissprot:ACRB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ACRB_ECOLI PSORT2 swissprot:ACRB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ACRB_ECOLI Pfam PF00873 http://pfam.xfam.org/family/PF00873 Phobius swissprot:ACRB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ACRB_ECOLI PhylomeDB P31224 http://phylomedb.org/?seqid=P31224 ProteinModelPortal P31224 http://www.proteinmodelportal.org/query/uniprot/P31224 PubMed 10920254 http://www.ncbi.nlm.nih.gov/pubmed/10920254 PubMed 12374972 http://www.ncbi.nlm.nih.gov/pubmed/12374972 PubMed 12738864 http://www.ncbi.nlm.nih.gov/pubmed/12738864 PubMed 15228545 http://www.ncbi.nlm.nih.gov/pubmed/15228545 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16915237 http://www.ncbi.nlm.nih.gov/pubmed/16915237 PubMed 16946072 http://www.ncbi.nlm.nih.gov/pubmed/16946072 PubMed 17194213 http://www.ncbi.nlm.nih.gov/pubmed/17194213 PubMed 18761695 http://www.ncbi.nlm.nih.gov/pubmed/18761695 PubMed 23010927 http://www.ncbi.nlm.nih.gov/pubmed/23010927 PubMed 7651136 http://www.ncbi.nlm.nih.gov/pubmed/7651136 PubMed 8407802 http://www.ncbi.nlm.nih.gov/pubmed/8407802 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414995 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414995 RefSeq WP_001132469 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001132469 SMR P31224 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31224 STRING 511145.b0462 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0462&targetmode=cogs STRING COG0841 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0841&targetmode=cogs SUPFAM SSF82714 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF82714 TCDB 2.A.6.2 http://www.tcdb.org/search/result.php?tc=2.A.6.2 TIGRFAMs TIGR00915 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00915 UniProtKB ACRB_ECOLI http://www.uniprot.org/uniprot/ACRB_ECOLI UniProtKB-AC P31224 http://www.uniprot.org/uniprot/P31224 charge swissprot:ACRB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ACRB_ECOLI eggNOG COG0841 http://eggnogapi.embl.de/nog_data/html/tree/COG0841 eggNOG ENOG4105BZS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZS epestfind swissprot:ACRB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ACRB_ECOLI garnier swissprot:ACRB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ACRB_ECOLI helixturnhelix swissprot:ACRB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ACRB_ECOLI hmoment swissprot:ACRB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ACRB_ECOLI iep swissprot:ACRB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ACRB_ECOLI inforesidue swissprot:ACRB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ACRB_ECOLI octanol swissprot:ACRB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ACRB_ECOLI pepcoil swissprot:ACRB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ACRB_ECOLI pepdigest swissprot:ACRB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ACRB_ECOLI pepinfo swissprot:ACRB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ACRB_ECOLI pepnet swissprot:ACRB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ACRB_ECOLI pepstats swissprot:ACRB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ACRB_ECOLI pepwheel swissprot:ACRB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ACRB_ECOLI pepwindow swissprot:ACRB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ACRB_ECOLI sigcleave swissprot:ACRB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ACRB_ECOLI ## Database ID URL or Descriptions # BioGrid 4259480 311 # BioGrid 4259820 219 # CAUTION Could be the product of a pseudogene. The gene coding for this protein is interrupted by a IS3B element between amino acids 486 and 487. {ECO 0000305}. # EcoGene EG13605 yaiT # GO_component GO:0019867 outer membrane; IEA:InterPro. # GO_process GO:0007155 cell adhesion; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0007155 cell adhesion # Gene3D 2.40.128.130 -; 1. # InterPro IPR003991 Pertactin_virulence_factor # InterPro IPR004899 Pertactin_central # InterPro IPR005546 Autotransporte_beta # InterPro IPR006315 OM_autotransptr_brl # InterPro IPR011050 Pectin_lyase_fold/virulence # Organism YAIT_ECOLI Escherichia coli (strain K12) # PATRIC 48659944 VBIEscCol107702_0366 # PIR C64765 C64765 # PIR F64765 F64765 # PRINTS PR01484 PRTACTNFAMLY # PROSITE PS51208 AUTOTRANSPORTER # Pfam PF03212 Pertactin # Pfam PF03797 Autotransporter # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAIT_ECOLI Putative uncharacterized protein YaiT # RefSeq WP_000556441 NZ_CP014272.1 # SIMILARITY Contains 1 autotransporter (TC 1.B.12) domain. {ECO:0000255|PROSITE-ProRule PRU00556}. # SMART SM00869 Autotransporter # SUPFAM SSF103515 SSF103515 # SUPFAM SSF51126 SSF51126 # TIGRFAMs TIGR01414 autotrans_barl BLAST swissprot:YAIT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAIT_ECOLI BioCyc ECOL316407:JW0362-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0362-MONOMER BioCyc ECOL316407:JW5051-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5051-MONOMER BioCyc EcoCyc:G6222-MONOMER http://biocyc.org/getid?id=EcoCyc:G6222-MONOMER BioCyc EcoCyc:G6225-MONOMER http://biocyc.org/getid?id=EcoCyc:G6225-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB3373 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3373 EcoGene EG13605 http://www.ecogene.org/geneInfo.php?eg_id=EG13605 EnsemblBacteria BAE76152 http://www.ensemblgenomes.org/id/BAE76152 EnsemblBacteria BAE76152 http://www.ensemblgenomes.org/id/BAE76152 EnsemblBacteria BAE76152 http://www.ensemblgenomes.org/id/BAE76152 EnsemblBacteria BAE76155 http://www.ensemblgenomes.org/id/BAE76155 EnsemblBacteria BAE76155 http://www.ensemblgenomes.org/id/BAE76155 EnsemblBacteria BAE76155 http://www.ensemblgenomes.org/id/BAE76155 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0019867 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019867 GO_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 Gene3D 2.40.128.130 http://www.cathdb.info/version/latest/superfamily/2.40.128.130 HOGENOM HOG000117445 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117445&db=HOGENOM6 IntAct P77199 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77199* InterPro IPR003991 http://www.ebi.ac.uk/interpro/entry/IPR003991 InterPro IPR004899 http://www.ebi.ac.uk/interpro/entry/IPR004899 InterPro IPR005546 http://www.ebi.ac.uk/interpro/entry/IPR005546 InterPro IPR006315 http://www.ebi.ac.uk/interpro/entry/IPR006315 InterPro IPR011050 http://www.ebi.ac.uk/interpro/entry/IPR011050 KEGG_Gene ecj:JW0362 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0362 KEGG_Gene ecj:JW5051 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5051 OMA PYADNAM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PYADNAM PRINTS PR01484 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01484 PROSITE PS51208 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51208 PSORT swissprot:YAIT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAIT_ECOLI PSORT-B swissprot:YAIT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAIT_ECOLI PSORT2 swissprot:YAIT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAIT_ECOLI Pfam PF03212 http://pfam.xfam.org/family/PF03212 Pfam PF03797 http://pfam.xfam.org/family/PF03797 Phobius swissprot:YAIT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAIT_ECOLI PhylomeDB P77199 http://phylomedb.org/?seqid=P77199 ProteinModelPortal P77199 http://www.proteinmodelportal.org/query/uniprot/P77199 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000556441 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000556441 SMART SM00869 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00869 STRING 316407.85674512 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85674512&targetmode=cogs SUPFAM SSF103515 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103515 SUPFAM SSF51126 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51126 TIGRFAMs TIGR01414 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01414 UniProtKB YAIT_ECOLI http://www.uniprot.org/uniprot/YAIT_ECOLI UniProtKB-AC P77199 http://www.uniprot.org/uniprot/P77199 charge swissprot:YAIT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAIT_ECOLI epestfind swissprot:YAIT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAIT_ECOLI garnier swissprot:YAIT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAIT_ECOLI helixturnhelix swissprot:YAIT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAIT_ECOLI hmoment swissprot:YAIT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAIT_ECOLI iep swissprot:YAIT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAIT_ECOLI inforesidue swissprot:YAIT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAIT_ECOLI octanol swissprot:YAIT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAIT_ECOLI pepcoil swissprot:YAIT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAIT_ECOLI pepdigest swissprot:YAIT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAIT_ECOLI pepinfo swissprot:YAIT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAIT_ECOLI pepnet swissprot:YAIT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAIT_ECOLI pepstats swissprot:YAIT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAIT_ECOLI pepwheel swissprot:YAIT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAIT_ECOLI pepwindow swissprot:YAIT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAIT_ECOLI sigcleave swissprot:YAIT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAIT_ECOLI ## Database ID URL or Descriptions # BioGrid 4262389 16 # DISRUPTION PHENOTYPE Deletion of this gene does not affect the ability to synthesize glutathionylspermidine. There is no visible differences between wild-type and mutant strain growth in LB media. {ECO:0000269|PubMed 23097746}. # EcoGene EG11165 ygiC # FUNCTION YGIC_ECOLI May be a ligase forming an amide bond. Shows ATPase activity. Despite its similarity to the C-terminal synthetase domain of Gss, is not a glutathionylspermidine (Gsp) synthetase. Cannot synthesize Gsp, glutathione (GSH), or GSH intermediates, from GSH and spermidine, cysteine and glutamate, gamma- glutamylcysteine and spermidine, and gamma-glutamylcysteine and glycine. Does not bind to Gsp. {ECO 0000269|PubMed 23097746}. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016874 ligase activity; IEA:UniProtKB-KW. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # IntAct P0ADT5 13 # InterPro IPR005494 GSPS_pre-ATP-grasp-like_dom # InterPro IPR016185 PreATP-grasp_dom # Organism YGIC_ECOLI Escherichia coli (strain K12) # PATRIC 32121486 VBIEscCol129921_3130 # PIR S22361 S22361 # Pfam PF03738 GSP_synth # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGIC_ECOLI Putative acid--amine ligase YgiC # RefSeq NP_417510 NC_000913.3 # RefSeq WP_000442860 NZ_LN832404.1 # SIMILARITY Belongs to the glutathionylspermidine synthase preATP- grasp family. {ECO 0000305}. # SUPFAM SSF52440 SSF52440 # eggNOG COG0754 LUCA # eggNOG ENOG4106032 Bacteria BLAST swissprot:YGIC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGIC_ECOLI BioCyc ECOL316407:JW3006-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3006-MONOMER BioCyc EcoCyc:EG11165-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11165-MONOMER DIP DIP-48176N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48176N DOI 10.1016/0167-4781(92)90535-8 http://dx.doi.org/10.1016/0167-4781(92)90535-8 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.3.1.- http://www.genome.jp/dbget-bin/www_bget?EC:6.3.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M77129 http://www.ebi.ac.uk/ena/data/view/M77129 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 ENZYME 6.3.1.- http://enzyme.expasy.org/EC/6.3.1.- EchoBASE EB1153 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1153 EcoGene EG11165 http://www.ecogene.org/geneInfo.php?eg_id=EG11165 EnsemblBacteria AAC76074 http://www.ensemblgenomes.org/id/AAC76074 EnsemblBacteria AAC76074 http://www.ensemblgenomes.org/id/AAC76074 EnsemblBacteria BAE77094 http://www.ensemblgenomes.org/id/BAE77094 EnsemblBacteria BAE77094 http://www.ensemblgenomes.org/id/BAE77094 EnsemblBacteria BAE77094 http://www.ensemblgenomes.org/id/BAE77094 EnsemblBacteria b3038 http://www.ensemblgenomes.org/id/b3038 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GeneID 947249 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947249 HOGENOM HOG000249104 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000249104&db=HOGENOM6 InParanoid P0ADT5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADT5 IntAct P0ADT5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADT5* IntEnz 6.3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.1 InterPro IPR005494 http://www.ebi.ac.uk/interpro/entry/IPR005494 InterPro IPR016185 http://www.ebi.ac.uk/interpro/entry/IPR016185 KEGG_Gene ecj:JW3006 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3006 KEGG_Gene eco:b3038 http://www.genome.jp/dbget-bin/www_bget?eco:b3038 MINT MINT-1290041 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1290041 OMA WSEEAYY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WSEEAYY PSORT swissprot:YGIC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGIC_ECOLI PSORT-B swissprot:YGIC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGIC_ECOLI PSORT2 swissprot:YGIC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGIC_ECOLI Pfam PF03738 http://pfam.xfam.org/family/PF03738 Phobius swissprot:YGIC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGIC_ECOLI PhylomeDB P0ADT5 http://phylomedb.org/?seqid=P0ADT5 ProteinModelPortal P0ADT5 http://www.proteinmodelportal.org/query/uniprot/P0ADT5 PubMed 1314093 http://www.ncbi.nlm.nih.gov/pubmed/1314093 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 23097746 http://www.ncbi.nlm.nih.gov/pubmed/23097746 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417510 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417510 RefSeq WP_000442860 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000442860 STRING 511145.b3038 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3038&targetmode=cogs SUPFAM SSF52440 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52440 UniProtKB YGIC_ECOLI http://www.uniprot.org/uniprot/YGIC_ECOLI UniProtKB-AC P0ADT5 http://www.uniprot.org/uniprot/P0ADT5 charge swissprot:YGIC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGIC_ECOLI eggNOG COG0754 http://eggnogapi.embl.de/nog_data/html/tree/COG0754 eggNOG ENOG4106032 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106032 epestfind swissprot:YGIC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGIC_ECOLI garnier swissprot:YGIC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGIC_ECOLI helixturnhelix swissprot:YGIC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGIC_ECOLI hmoment swissprot:YGIC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGIC_ECOLI iep swissprot:YGIC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGIC_ECOLI inforesidue swissprot:YGIC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGIC_ECOLI octanol swissprot:YGIC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGIC_ECOLI pepcoil swissprot:YGIC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGIC_ECOLI pepdigest swissprot:YGIC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGIC_ECOLI pepinfo swissprot:YGIC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGIC_ECOLI pepnet swissprot:YGIC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGIC_ECOLI pepstats swissprot:YGIC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGIC_ECOLI pepwheel swissprot:YGIC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGIC_ECOLI pepwindow swissprot:YGIC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGIC_ECOLI sigcleave swissprot:YGIC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGIC_ECOLI ## Database ID URL or Descriptions # AltName Phosphotransferase system, enzyme I {ECO:0000303|PubMed 2960675} # BIOPHYSICOCHEMICAL PROPERTIES PT1_ECOLI Kinetic parameters KM=0.11 mM for ZFPEP {ECO 0000269|PubMed 12705838}; KM=0.12 mM for EClPEP {ECO 0000269|PubMed 12705838}; KM=0.14 mM for PEP {ECO 0000269|PubMed 12705838}; KM=0.25 mM for ZClPEP {ECO 0000269|PubMed 12705838}; KM=0.43 mM for ZMePEP {ECO 0000269|PubMed 12705838}; Note=Kcat is 3830 min(-1) with PEP as substrate. Kcat is 370 min(-1) with ZFPEP as substrate. Kcat is 285 min(-1) with ZMePEP as substrate. Kcat is 15.8 min(-1) with ZClPEP as substrate. Kcat is 2.8 min(-1) with EClPEP as substrate. {ECO 0000269|PubMed 12705838}; # BRENDA 2.7.3 2026 # BioGrid 4260570 498 # CATALYTIC ACTIVITY Phosphoenolpyruvate + protein L-histidine = pyruvate + protein N(pi)-phospho-L-histidine. {ECO:0000269|PubMed 12705838}. # COFACTOR PT1_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 17053069}; # DOMAIN PT1_ECOLI The N-terminal domain contains the HPr binding site, the central domain the pyrophosphate/phosphate carrier histidine, and the C-terminal domain the pyruvate binding site. {ECO 0000269|PubMed 17053069}. # ENZYME REGULATION Inhibited by oxalate. {ECO:0000269|PubMed 12705838}. # EcoGene EG10789 ptsI # FUNCTION PT1_ECOLI General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (PubMed 7876255, PubMed 12705838, PubMed 17053069). Can also use (Z)-3-fluoro-PEP (ZFPEP), (Z)-3-methyl-PEP (ZMePEP), (Z)-3-chloro-PEP (ZClPEP) and (E)-3-chloro-PEP (EClPEP) as alternative phosphoryl donors (PubMed 12705838). {ECO 0000269|PubMed 12705838, ECO 0000269|PubMed 17053069, ECO 0000269|PubMed 7876255}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0019197 phosphoenolpyruvate-dependent sugar phosphotransferase complex; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0008965 phosphoenolpyruvate-protein phosphotransferase activity; IDA:EcoCyc. # GO_function GO:0016301 kinase activity; IEA:UniProtKB-KW. # GO_function GO:0046872 metal ion binding; IDA:EcoCyc. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # Gene3D 1.10.274.10 -; 1. # Gene3D 3.20.20.60 -; 1. # Gene3D 3.50.30.10 -; 1. # INTERACTION PT1_ECOLI P11989 bglG; NbExp=3; IntAct=EBI-551533, EBI-545674; P0AA04 ptsH; NbExp=2; IntAct=EBI-551533, EBI-902853; # IntAct P08839 14 # InterPro IPR000121 PEP_util_C # InterPro IPR006318 PTS_EI-like # InterPro IPR008279 PEP-util_enz_mobile_dom # InterPro IPR008731 PTS_EIN # InterPro IPR015813 Pyrv/PenolPyrv_Kinase-like_dom # InterPro IPR018274 PEP_util_AS # InterPro IPR023151 PEP_util_CS # InterPro IPR024692 PTS_EI # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02060 Phosphotransferase system (PTS) # MISCELLANEOUS Enzyme I of the sugar PTS has been shown to phosphorylate NPr of the nitrogen-metabolic PTS, though much less efficiently than it does HPr. This process may link carbon and nitrogen assimilation. {ECO:0000269|PubMed 7876255}. # MISCELLANEOUS The reaction takes place in three steps, mediated by a phosphocarrier histidine residue located on the surface of the central domain. The two first partial reactions are catalyzed at an active site located on the N-terminal domain, and the third partial reaction is catalyzed at an active site located on the C- terminal domain. For catalytic turnover, the central domain swivels from the concave surface of the N-terminal domain to that of the C-terminal domain. {ECO:0000269|PubMed 17053069}. # Organism PT1_ECOLI Escherichia coli (strain K12) # PATRIC 32120215 VBIEscCol129921_2510 # PDB 1EZA NMR; -; A=1-258 # PDB 1EZB NMR; -; A=1-258 # PDB 1EZC NMR; -; A=1-258 # PDB 1EZD NMR; -; A=1-258 # PDB 1ZYM X-ray; 2.50 A; A/B=1-258 # PDB 2EZA NMR; -; A=1-258 # PDB 2EZB NMR; -; A=1-258 # PDB 2EZC NMR; -; A=1-258 # PDB 2HWG X-ray; 2.70 A; A/B=1-575 # PDB 2KX9 Other; -; A/B=1-573 # PDB 2L5H Other; -; A/B=1-573 # PDB 2MP0 NMR; -; A=1-258 # PDB 2N5T Other; -; A/B=1-575 # PDB 2XDF Other; -; A/B=1-573 # PDB 3EZA NMR; -; A=1-249 # PDB 3EZB NMR; -; A=1-258 # PDB 3EZE NMR; -; A=1-258 # PIR B29785 WQECPI # PIRSF PIRSF000732 PTS_enzyme_I # PROSITE PS00370 PEP_ENZYMES_PHOS_SITE # PROSITE PS00742 PEP_ENZYMES_2 # Pfam PF00391 PEP-utilizers # Pfam PF02896 PEP-utilizers_C # Pfam PF05524 PEP-utilisers_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Phosphoenolpyruvate-protein phosphotransferase {ECO:0000303|PubMed 2960675} # RefSeq NP_416911 NC_000913.3 # RefSeq WP_000623140 NZ_LN832404.1 # SIMILARITY Belongs to the PEP-utilizing enzyme family. {ECO 0000305}. # SUBCELLULAR LOCATION PT1_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT PT1_ECOLI Homodimer. {ECO 0000269|PubMed 12705838, ECO 0000269|PubMed 17053069}. # SUPFAM SSF47831 SSF47831 # SUPFAM SSF51621 SSF51621 # SUPFAM SSF52009 SSF52009 # TCDB 8.A.7.1 the phosphotransferase system enzyme i (ei) family # TIGRFAMs TIGR01417 PTS_I_fam # eggNOG COG1080 LUCA # eggNOG ENOG4105BZ3 Bacteria BLAST swissprot:PT1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PT1_ECOLI BioCyc ECOL316407:JW2409-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2409-MONOMER BioCyc EcoCyc:PTSI-MONOMER http://biocyc.org/getid?id=EcoCyc:PTSI-MONOMER COG COG1080 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1080 DIP DIP-10603N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10603N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1002/pro.5560070329 http://dx.doi.org/10.1002/pro.5560070329 DOI 10.1016/0378-1119(85)90172-6 http://dx.doi.org/10.1016/0378-1119(85)90172-6 DOI 10.1016/S0969-2126(96)00092-5 http://dx.doi.org/10.1016/S0969-2126(96)00092-5 DOI 10.1021/bi034007f http://dx.doi.org/10.1021/bi034007f DOI 10.1021/bi962924y http://dx.doi.org/10.1021/bi962924y DOI 10.1038/5854 http://dx.doi.org/10.1038/5854 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0607587103 http://dx.doi.org/10.1073/pnas.0607587103 DOI 10.1074/jbc.270.9.4822 http://dx.doi.org/10.1074/jbc.270.9.4822 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.3.9 {ECO:0000269|PubMed:12705838} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.3.9 {ECO:0000269|PubMed:12705838} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J02796 http://www.ebi.ac.uk/ena/data/view/J02796 EMBL M10425 http://www.ebi.ac.uk/ena/data/view/M10425 EMBL M21451 http://www.ebi.ac.uk/ena/data/view/M21451 EMBL M21994 http://www.ebi.ac.uk/ena/data/view/M21994 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.3.9 {ECO:0000269|PubMed:12705838} http://enzyme.expasy.org/EC/2.7.3.9 {ECO:0000269|PubMed:12705838} EchoBASE EB0782 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0782 EcoGene EG10789 http://www.ecogene.org/geneInfo.php?eg_id=EG10789 EnsemblBacteria AAC75469 http://www.ensemblgenomes.org/id/AAC75469 EnsemblBacteria AAC75469 http://www.ensemblgenomes.org/id/AAC75469 EnsemblBacteria BAA16290 http://www.ensemblgenomes.org/id/BAA16290 EnsemblBacteria BAA16290 http://www.ensemblgenomes.org/id/BAA16290 EnsemblBacteria BAA16290 http://www.ensemblgenomes.org/id/BAA16290 EnsemblBacteria b2416 http://www.ensemblgenomes.org/id/b2416 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0019197 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019197 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0008965 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008965 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 1.10.274.10 http://www.cathdb.info/version/latest/superfamily/1.10.274.10 Gene3D 3.20.20.60 http://www.cathdb.info/version/latest/superfamily/3.20.20.60 Gene3D 3.50.30.10 http://www.cathdb.info/version/latest/superfamily/3.50.30.10 GeneID 946879 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946879 HOGENOM HOG000278513 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278513&db=HOGENOM6 InParanoid P08839 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P08839 IntAct P08839 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P08839* IntEnz 2.7.3.9 {ECO:0000269|PubMed:12705838} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.3.9 {ECO:0000269|PubMed:12705838} InterPro IPR000121 http://www.ebi.ac.uk/interpro/entry/IPR000121 InterPro IPR006318 http://www.ebi.ac.uk/interpro/entry/IPR006318 InterPro IPR008279 http://www.ebi.ac.uk/interpro/entry/IPR008279 InterPro IPR008731 http://www.ebi.ac.uk/interpro/entry/IPR008731 InterPro IPR015813 http://www.ebi.ac.uk/interpro/entry/IPR015813 InterPro IPR018274 http://www.ebi.ac.uk/interpro/entry/IPR018274 InterPro IPR023151 http://www.ebi.ac.uk/interpro/entry/IPR023151 InterPro IPR024692 http://www.ebi.ac.uk/interpro/entry/IPR024692 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2409 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2409 KEGG_Gene eco:b2416 http://www.genome.jp/dbget-bin/www_bget?eco:b2416 KEGG_Orthology KO:K08483 http://www.genome.jp/dbget-bin/www_bget?KO:K08483 KEGG_Pathway ko02060 http://www.genome.jp/kegg-bin/show_pathway?ko02060 MINT MINT-5290328 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5290328 OMA DYVLGFA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DYVLGFA PDB 1EZA http://www.ebi.ac.uk/pdbe-srv/view/entry/1EZA PDB 1EZB http://www.ebi.ac.uk/pdbe-srv/view/entry/1EZB PDB 1EZC http://www.ebi.ac.uk/pdbe-srv/view/entry/1EZC PDB 1EZD http://www.ebi.ac.uk/pdbe-srv/view/entry/1EZD PDB 1ZYM http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZYM PDB 2EZA http://www.ebi.ac.uk/pdbe-srv/view/entry/2EZA PDB 2EZB http://www.ebi.ac.uk/pdbe-srv/view/entry/2EZB PDB 2EZC http://www.ebi.ac.uk/pdbe-srv/view/entry/2EZC PDB 2HWG http://www.ebi.ac.uk/pdbe-srv/view/entry/2HWG PDB 2KX9 http://www.ebi.ac.uk/pdbe-srv/view/entry/2KX9 PDB 2L5H http://www.ebi.ac.uk/pdbe-srv/view/entry/2L5H PDB 2MP0 http://www.ebi.ac.uk/pdbe-srv/view/entry/2MP0 PDB 2N5T http://www.ebi.ac.uk/pdbe-srv/view/entry/2N5T PDB 2XDF http://www.ebi.ac.uk/pdbe-srv/view/entry/2XDF PDB 3EZA http://www.ebi.ac.uk/pdbe-srv/view/entry/3EZA PDB 3EZB http://www.ebi.ac.uk/pdbe-srv/view/entry/3EZB PDB 3EZE http://www.ebi.ac.uk/pdbe-srv/view/entry/3EZE PDBsum 1EZA http://www.ebi.ac.uk/pdbsum/1EZA PDBsum 1EZB http://www.ebi.ac.uk/pdbsum/1EZB PDBsum 1EZC http://www.ebi.ac.uk/pdbsum/1EZC PDBsum 1EZD http://www.ebi.ac.uk/pdbsum/1EZD PDBsum 1ZYM http://www.ebi.ac.uk/pdbsum/1ZYM PDBsum 2EZA http://www.ebi.ac.uk/pdbsum/2EZA PDBsum 2EZB http://www.ebi.ac.uk/pdbsum/2EZB PDBsum 2EZC http://www.ebi.ac.uk/pdbsum/2EZC PDBsum 2HWG http://www.ebi.ac.uk/pdbsum/2HWG PDBsum 2KX9 http://www.ebi.ac.uk/pdbsum/2KX9 PDBsum 2L5H http://www.ebi.ac.uk/pdbsum/2L5H PDBsum 2MP0 http://www.ebi.ac.uk/pdbsum/2MP0 PDBsum 2N5T http://www.ebi.ac.uk/pdbsum/2N5T PDBsum 2XDF http://www.ebi.ac.uk/pdbsum/2XDF PDBsum 3EZA http://www.ebi.ac.uk/pdbsum/3EZA PDBsum 3EZB http://www.ebi.ac.uk/pdbsum/3EZB PDBsum 3EZE http://www.ebi.ac.uk/pdbsum/3EZE PROSITE PS00370 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00370 PROSITE PS00742 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00742 PSORT swissprot:PT1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PT1_ECOLI PSORT-B swissprot:PT1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PT1_ECOLI PSORT2 swissprot:PT1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PT1_ECOLI Pfam PF00391 http://pfam.xfam.org/family/PF00391 Pfam PF02896 http://pfam.xfam.org/family/PF02896 Pfam PF05524 http://pfam.xfam.org/family/PF05524 Phobius swissprot:PT1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PT1_ECOLI PhylomeDB P08839 http://phylomedb.org/?seqid=P08839 ProteinModelPortal P08839 http://www.proteinmodelportal.org/query/uniprot/P08839 PubMed 10048929 http://www.ncbi.nlm.nih.gov/pubmed/10048929 PubMed 12705838 http://www.ncbi.nlm.nih.gov/pubmed/12705838 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17053069 http://www.ncbi.nlm.nih.gov/pubmed/17053069 PubMed 2411636 http://www.ncbi.nlm.nih.gov/pubmed/2411636 PubMed 2457575 http://www.ncbi.nlm.nih.gov/pubmed/2457575 PubMed 2960675 http://www.ncbi.nlm.nih.gov/pubmed/2960675 PubMed 3290198 http://www.ncbi.nlm.nih.gov/pubmed/3290198 PubMed 7876255 http://www.ncbi.nlm.nih.gov/pubmed/7876255 PubMed 8805571 http://www.ncbi.nlm.nih.gov/pubmed/8805571 PubMed 9054557 http://www.ncbi.nlm.nih.gov/pubmed/9054557 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9541412 http://www.ncbi.nlm.nih.gov/pubmed/9541412 RefSeq NP_416911 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416911 RefSeq WP_000623140 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000623140 SMR P08839 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P08839 STRING 511145.b2416 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2416&targetmode=cogs STRING COG1080 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1080&targetmode=cogs SUPFAM SSF47831 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47831 SUPFAM SSF51621 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51621 SUPFAM SSF52009 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52009 SWISS-2DPAGE P08839 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P08839 TCDB 8.A.7.1 http://www.tcdb.org/search/result.php?tc=8.A.7.1 TIGRFAMs TIGR01417 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01417 UniProtKB PT1_ECOLI http://www.uniprot.org/uniprot/PT1_ECOLI UniProtKB-AC P08839 http://www.uniprot.org/uniprot/P08839 charge swissprot:PT1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PT1_ECOLI eggNOG COG1080 http://eggnogapi.embl.de/nog_data/html/tree/COG1080 eggNOG ENOG4105BZ3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZ3 epestfind swissprot:PT1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PT1_ECOLI garnier swissprot:PT1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PT1_ECOLI helixturnhelix swissprot:PT1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PT1_ECOLI hmoment swissprot:PT1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PT1_ECOLI iep swissprot:PT1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PT1_ECOLI inforesidue swissprot:PT1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PT1_ECOLI octanol swissprot:PT1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PT1_ECOLI pepcoil swissprot:PT1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PT1_ECOLI pepdigest swissprot:PT1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PT1_ECOLI pepinfo swissprot:PT1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PT1_ECOLI pepnet swissprot:PT1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PT1_ECOLI pepstats swissprot:PT1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PT1_ECOLI pepwheel swissprot:PT1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PT1_ECOLI pepwindow swissprot:PT1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PT1_ECOLI sigcleave swissprot:PT1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PT1_ECOLI ## Database ID URL or Descriptions # BioGrid 4262953 208 # EcoGene EG11954 mdtN # FUNCTION MDTN_ECOLI Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015546 sulfathiazole transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0006855 drug transmembrane transport; IMP:EcoCyc. # GO_process GO:0015906 sulfathiazole transport; IMP:EcoCyc. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # GOslim_process GO:0055085 transmembrane transport # INDUCTION Induced by LeuO, part of the mdtNO operon. {ECO:0000269|PubMed 19429622}. # IntAct P32716 3 # InterPro IPR005694 Emr # InterPro IPR030196 MdtN # KEGG_Brite ko02000 Transporters # Organism MDTN_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30367:SF1 PTHR30367:SF1 # PATRIC 32123717 VBIEscCol129921_4207 # PIR A65217 A65217 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MDTN_ECOLI Multidrug resistance protein MdtN # RefSeq NP_418506 NC_000913.3 # RefSeq WP_000446378 NZ_LN832404.1 # SIMILARITY Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. {ECO 0000305}. # SUBCELLULAR LOCATION MDTN_ECOLI Cell inner membrane {ECO 0000305}; Single- pass type II membrane protein {ECO 0000305}. # SUBUNIT MDTN_ECOLI Could be part of a tripartite efflux system composed of MdtN, MdtO and MdtP. # TIGRFAMs TIGR00998 8a0101 # eggNOG COG1566 LUCA # eggNOG ENOG4105J12 Bacteria BLAST swissprot:MDTN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MDTN_ECOLI BioCyc ECOL316407:JW4043-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4043-MONOMER BioCyc EcoCyc:EG11954-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11954-MONOMER COG COG1566 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1566 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AAC.45.4.1126-1136.2001 http://dx.doi.org/10.1128/AAC.45.4.1126-1136.2001 DOI 10.1128/JB.00108-09 http://dx.doi.org/10.1128/JB.00108-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1897 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1897 EcoGene EG11954 http://www.ecogene.org/geneInfo.php?eg_id=EG11954 EnsemblBacteria AAD13465 http://www.ensemblgenomes.org/id/AAD13465 EnsemblBacteria AAD13465 http://www.ensemblgenomes.org/id/AAD13465 EnsemblBacteria BAE78084 http://www.ensemblgenomes.org/id/BAE78084 EnsemblBacteria BAE78084 http://www.ensemblgenomes.org/id/BAE78084 EnsemblBacteria BAE78084 http://www.ensemblgenomes.org/id/BAE78084 EnsemblBacteria b4082 http://www.ensemblgenomes.org/id/b4082 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015546 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015546 GO_process GO:0006855 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006855 GO_process GO:0015906 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015906 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 948598 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948598 HOGENOM HOG000112073 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000112073&db=HOGENOM6 InParanoid P32716 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32716 IntAct P32716 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32716* InterPro IPR005694 http://www.ebi.ac.uk/interpro/entry/IPR005694 InterPro IPR030196 http://www.ebi.ac.uk/interpro/entry/IPR030196 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW4043 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4043 KEGG_Gene eco:b4082 http://www.genome.jp/dbget-bin/www_bget?eco:b4082 KEGG_Orthology KO:K15549 http://www.genome.jp/dbget-bin/www_bget?KO:K15549 OMA STMRPIF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=STMRPIF PANTHER PTHR30367:SF1 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30367:SF1 PSORT swissprot:MDTN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MDTN_ECOLI PSORT-B swissprot:MDTN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MDTN_ECOLI PSORT2 swissprot:MDTN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MDTN_ECOLI Phobius swissprot:MDTN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MDTN_ECOLI PhylomeDB P32716 http://phylomedb.org/?seqid=P32716 ProteinModelPortal P32716 http://www.proteinmodelportal.org/query/uniprot/P32716 PubMed 11257026 http://www.ncbi.nlm.nih.gov/pubmed/11257026 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19429622 http://www.ncbi.nlm.nih.gov/pubmed/19429622 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418506 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418506 RefSeq WP_000446378 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000446378 SMR P32716 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32716 STRING 511145.b4082 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4082&targetmode=cogs STRING COG1566 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1566&targetmode=cogs TIGRFAMs TIGR00998 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00998 UniProtKB MDTN_ECOLI http://www.uniprot.org/uniprot/MDTN_ECOLI UniProtKB-AC P32716 http://www.uniprot.org/uniprot/P32716 charge swissprot:MDTN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MDTN_ECOLI eggNOG COG1566 http://eggnogapi.embl.de/nog_data/html/tree/COG1566 eggNOG ENOG4105J12 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105J12 epestfind swissprot:MDTN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MDTN_ECOLI garnier swissprot:MDTN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MDTN_ECOLI helixturnhelix swissprot:MDTN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MDTN_ECOLI hmoment swissprot:MDTN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MDTN_ECOLI iep swissprot:MDTN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MDTN_ECOLI inforesidue swissprot:MDTN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MDTN_ECOLI octanol swissprot:MDTN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MDTN_ECOLI pepcoil swissprot:MDTN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MDTN_ECOLI pepdigest swissprot:MDTN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MDTN_ECOLI pepinfo swissprot:MDTN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MDTN_ECOLI pepnet swissprot:MDTN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MDTN_ECOLI pepstats swissprot:MDTN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MDTN_ECOLI pepwheel swissprot:MDTN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MDTN_ECOLI pepwindow swissprot:MDTN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MDTN_ECOLI sigcleave swissprot:MDTN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MDTN_ECOLI ## Database ID URL or Descriptions # AltName MTFA_ECOLI Mlc titration factor A # BioGrid 4261319 13 # EcoGene EG13377 mtfA # FUNCTION MTFA_ECOLI Involved in the regulation of ptsG expression by binding and inactivating Mlc. {ECO 0000269|PubMed 16855233}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004177 aminopeptidase activity; IDA:EcoCyc. # GO_function GO:0008134 transcription factor binding; IPI:EcoCyc. # GO_function GO:0008237 metallopeptidase activity; IEA:InterPro. # GO_process GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0008134 transcription factor binding # GOslim_function GO:0008233 peptidase activity # GOslim_process GO:0008150 biological_process # Gene3D 3.40.390.10 -; 1. # HAMAP MF_01593 MtfA # INTERACTION MTFA_ECOLI P50456 mlc; NbExp=2; IntAct=EBI-1126682, EBI-1116104; # IntAct P76346 19 # InterPro IPR010384 MtfA_fam # InterPro IPR024079 MetalloPept_cat_dom # Organism MTFA_ECOLI Escherichia coli (strain K12) # PATRIC 32119283 VBIEscCol129921_2055 # Pfam PF06167 Peptidase_M90 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MTFA_ECOLI Protein MtfA # RefSeq NP_416484 NC_000913.3 # RefSeq WP_001302302 NZ_LN832404.1 # SIMILARITY Belongs to the MtfA family. {ECO 0000305}. # SUBCELLULAR LOCATION MTFA_ECOLI Cytoplasm {ECO 0000269|PubMed 16855233}. # SUBUNIT Interacts with Mlc with high affinity. {ECO:0000269|PubMed 16855233}. # eggNOG COG3228 LUCA # eggNOG ENOG4105EXZ Bacteria BLAST swissprot:MTFA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MTFA_ECOLI BioCyc ECOL316407:JW1958-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1958-MONOMER BioCyc EcoCyc:G7063-MONOMER http://biocyc.org/getid?id=EcoCyc:G7063-MONOMER BioCyc MetaCyc:G7063-MONOMER http://biocyc.org/getid?id=MetaCyc:G7063-MONOMER COG COG3228 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3228 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00219-06 http://dx.doi.org/10.1128/JB.00219-06 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3159 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3159 EcoGene EG13377 http://www.ecogene.org/geneInfo.php?eg_id=EG13377 EnsemblBacteria AAC75041 http://www.ensemblgenomes.org/id/AAC75041 EnsemblBacteria AAC75041 http://www.ensemblgenomes.org/id/AAC75041 EnsemblBacteria BAE76562 http://www.ensemblgenomes.org/id/BAE76562 EnsemblBacteria BAE76562 http://www.ensemblgenomes.org/id/BAE76562 EnsemblBacteria BAE76562 http://www.ensemblgenomes.org/id/BAE76562 EnsemblBacteria b1976 http://www.ensemblgenomes.org/id/b1976 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004177 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004177 GO_function GO:0008134 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008134 GO_function GO:0008237 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008237 GO_process GO:0043433 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043433 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0008134 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008134 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.390.10 http://www.cathdb.info/version/latest/superfamily/3.40.390.10 GeneID 946489 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946489 HAMAP MF_01593 http://hamap.expasy.org/unirule/MF_01593 HOGENOM HOG000261077 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261077&db=HOGENOM6 IntAct P76346 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76346* InterPro IPR010384 http://www.ebi.ac.uk/interpro/entry/IPR010384 InterPro IPR024079 http://www.ebi.ac.uk/interpro/entry/IPR024079 KEGG_Gene ecj:JW1958 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1958 KEGG_Gene eco:b1976 http://www.genome.jp/dbget-bin/www_bget?eco:b1976 KEGG_Orthology KO:K09933 http://www.genome.jp/dbget-bin/www_bget?KO:K09933 OMA VLYPGEF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VLYPGEF PSORT swissprot:MTFA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MTFA_ECOLI PSORT-B swissprot:MTFA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MTFA_ECOLI PSORT2 swissprot:MTFA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MTFA_ECOLI Pfam PF06167 http://pfam.xfam.org/family/PF06167 Phobius swissprot:MTFA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MTFA_ECOLI PhylomeDB P76346 http://phylomedb.org/?seqid=P76346 ProteinModelPortal P76346 http://www.proteinmodelportal.org/query/uniprot/P76346 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16855233 http://www.ncbi.nlm.nih.gov/pubmed/16855233 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416484 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416484 RefSeq WP_001302302 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001302302 SMR P76346 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76346 STRING 511145.b1976 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1976&targetmode=cogs STRING COG3228 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3228&targetmode=cogs UniProtKB MTFA_ECOLI http://www.uniprot.org/uniprot/MTFA_ECOLI UniProtKB-AC P76346 http://www.uniprot.org/uniprot/P76346 charge swissprot:MTFA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MTFA_ECOLI eggNOG COG3228 http://eggnogapi.embl.de/nog_data/html/tree/COG3228 eggNOG ENOG4105EXZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EXZ epestfind swissprot:MTFA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MTFA_ECOLI garnier swissprot:MTFA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MTFA_ECOLI helixturnhelix swissprot:MTFA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MTFA_ECOLI hmoment swissprot:MTFA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MTFA_ECOLI iep swissprot:MTFA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MTFA_ECOLI inforesidue swissprot:MTFA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MTFA_ECOLI octanol swissprot:MTFA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MTFA_ECOLI pepcoil swissprot:MTFA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MTFA_ECOLI pepdigest swissprot:MTFA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MTFA_ECOLI pepinfo swissprot:MTFA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MTFA_ECOLI pepnet swissprot:MTFA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MTFA_ECOLI pepstats swissprot:MTFA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MTFA_ECOLI pepwheel swissprot:MTFA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MTFA_ECOLI pepwindow swissprot:MTFA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MTFA_ECOLI sigcleave swissprot:MTFA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MTFA_ECOLI ## Database ID URL or Descriptions # BioGrid 4263012 238 # CATALYTIC ACTIVITY PAAJ_ECOLI 2,3-didehydroadipyl-CoA + acetyl-CoA = CoA + 3-oxo-5,6-didehydrosuberyl-CoA. {ECO 0000269|PubMed 17259607, ECO 0000269|PubMed 20660314}. # CATALYTIC ACTIVITY PAAJ_ECOLI Succinyl-CoA + acetyl-CoA = CoA + 3-oxoadipyl- CoA. {ECO 0000269|PubMed 17259607, ECO 0000269|PubMed 20660314}. # DISRUPTION PHENOTYPE Mutants are unable to use phenylacetate as a carbon source. {ECO:0000269|PubMed 12846838}. # EcoGene EG13744 paaJ # FUNCTION PAAJ_ECOLI Catalyzes the thiolytic cleavage of the beta-keto C8 intermediate 3-oxo-5,6-dehydrosuberyl-CoA with CoA to yield the C6 intermediate 2,3-dehydroadipyl-CoA and acetyl-CoA. Besides it catalyzes also the last step of the pathway, in which 3-oxoadipyl- CoA similarly is cleaved to acetyl-CoA and succinyl-CoA. {ECO 0000269|PubMed 17259607, ECO 0000269|PubMed 20660314, ECO 0000269|PubMed 9748275}. # GO_function GO:0003988 acetyl-CoA C-acyltransferase activity; IBA:GO_Central. # GO_function GO:0016740 transferase activity; IDA:EcoCyc. # GO_function GO:0033812 3-oxoadipyl-CoA thiolase activity; IDA:UniProtKB. # GO_process GO:0006635 fatty acid beta-oxidation; IBA:GO_Central. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0010124 phenylacetate catabolic process; IMP:UniProtKB. # GO_process GO:0019619 3,4-dihydroxybenzoate catabolic process; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.47.10 -; 4. # INDUCTION PAAJ_ECOLI Activated by cAMP receptor protein (CRP), integration host factor (IHF) and by phenylacetyl-coenzyme A (PA-CoA) that prevents PaaX from binding its target sequences. Inhibited by PaaX. {ECO 0000269|PubMed 10766858, ECO 0000269|PubMed 9748275}. # IntAct P0C7L2 5 # InterPro IPR002155 Thiolase # InterPro IPR012793 PcaF # InterPro IPR016039 Thiolase-like # InterPro IPR020610 Thiolase_AS # InterPro IPR020613 Thiolase_CS # InterPro IPR020615 Thiolase_acyl_enz_int_AS # InterPro IPR020616 Thiolase_N # InterPro IPR020617 Thiolase_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00360 Phenylalanine metabolism # Organism PAAJ_ECOLI Escherichia coli (strain K12) # PATHWAY PAAJ_ECOLI Aromatic compound metabolism; phenylacetate degradation. # PATRIC 32118080 VBIEscCol129921_1460 # PIR H64890 H64890 # PIRSF PIRSF000429 Ac-CoA_Ac_transf # PROSITE PS00098 THIOLASE_1 # PROSITE PS00099 THIOLASE_3 # PROSITE PS00737 THIOLASE_2 # Pfam PF00108 Thiolase_N # Pfam PF02803 Thiolase_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PAAJ_ECOLI 3-oxoadipyl-CoA/3-oxo-5,6-dehydrosuberyl-CoA thiolase # RefSeq NP_415915 NC_000913.3 # RefSeq WP_001206197 NZ_LN832404.1 # SIMILARITY Belongs to the thiolase family. {ECO 0000305}. # SUPFAM SSF53901 SSF53901; 2 # TIGRFAMs TIGR01930 AcCoA-C-Actrans # TIGRFAMs TIGR02430 pcaF # eggNOG COG0183 LUCA # eggNOG ENOG4105CHU Bacteria BLAST swissprot:PAAJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PAAJ_ECOLI BioCyc EcoCyc:G6718-MONOMER http://biocyc.org/getid?id=EcoCyc:G6718-MONOMER BioCyc MetaCyc:G6718-MONOMER http://biocyc.org/getid?id=MetaCyc:G6718-MONOMER COG COG0183 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0183 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1432-1033.2003.03683.x http://dx.doi.org/10.1046/j.1432-1033.2003.03683.x DOI 10.1073/pnas.1005399107 http://dx.doi.org/10.1073/pnas.1005399107 DOI 10.1074/jbc.273.40.25974 http://dx.doi.org/10.1074/jbc.273.40.25974 DOI 10.1074/jbc.275.16.12214 http://dx.doi.org/10.1074/jbc.275.16.12214 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1099/mic.0.2006/002444-0 http://dx.doi.org/10.1099/mic.0.2006/002444-0 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.174 {ECO:0000269|PubMed:17259607, ECO:0000269|PubMed:20660314} http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.174 {ECO:0000269|PubMed:17259607, ECO:0000269|PubMed:20660314} EC_number EC:2.3.1.223 {ECO:0000269|PubMed:17259607, ECO:0000269|PubMed:20660314} http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.223 {ECO:0000269|PubMed:17259607, ECO:0000269|PubMed:20660314} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.3.1.174 {ECO:0000269|PubMed:17259607, ECO:0000269|PubMed:20660314} http://enzyme.expasy.org/EC/2.3.1.174 {ECO:0000269|PubMed:17259607, ECO:0000269|PubMed:20660314} ENZYME 2.3.1.223 {ECO:0000269|PubMed:17259607, ECO:0000269|PubMed:20660314} http://enzyme.expasy.org/EC/2.3.1.223 {ECO:0000269|PubMed:17259607, ECO:0000269|PubMed:20660314} EchoBASE EB3507 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3507 EcoGene EG13744 http://www.ecogene.org/geneInfo.php?eg_id=EG13744 EnsemblBacteria AAC74479 http://www.ensemblgenomes.org/id/AAC74479 EnsemblBacteria AAC74479 http://www.ensemblgenomes.org/id/AAC74479 EnsemblBacteria BAA15002 http://www.ensemblgenomes.org/id/BAA15002 EnsemblBacteria BAA15002 http://www.ensemblgenomes.org/id/BAA15002 EnsemblBacteria BAA15002 http://www.ensemblgenomes.org/id/BAA15002 EnsemblBacteria b1397 http://www.ensemblgenomes.org/id/b1397 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003988 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003988 GO_function GO:0016740 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016740 GO_function GO:0033812 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033812 GO_process GO:0006635 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006635 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0010124 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010124 GO_process GO:0019619 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019619 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.47.10 http://www.cathdb.info/version/latest/superfamily/3.40.47.10 GeneID 946121 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946121 HOGENOM HOG000012239 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000012239&db=HOGENOM6 InParanoid P0C7L2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0C7L2 IntAct P0C7L2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0C7L2* IntEnz 2.3.1.174 {ECO:0000269|PubMed:17259607, ECO:0000269|PubMed:20660314} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.174 {ECO:0000269|PubMed:17259607, ECO:0000269|PubMed:20660314} IntEnz 2.3.1.223 {ECO:0000269|PubMed:17259607, ECO:0000269|PubMed:20660314} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.223 {ECO:0000269|PubMed:17259607, ECO:0000269|PubMed:20660314} InterPro IPR002155 http://www.ebi.ac.uk/interpro/entry/IPR002155 InterPro IPR012793 http://www.ebi.ac.uk/interpro/entry/IPR012793 InterPro IPR016039 http://www.ebi.ac.uk/interpro/entry/IPR016039 InterPro IPR020610 http://www.ebi.ac.uk/interpro/entry/IPR020610 InterPro IPR020613 http://www.ebi.ac.uk/interpro/entry/IPR020613 InterPro IPR020615 http://www.ebi.ac.uk/interpro/entry/IPR020615 InterPro IPR020616 http://www.ebi.ac.uk/interpro/entry/IPR020616 InterPro IPR020617 http://www.ebi.ac.uk/interpro/entry/IPR020617 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1392 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1392 KEGG_Gene eco:b1397 http://www.genome.jp/dbget-bin/www_bget?eco:b1397 KEGG_Orthology KO:K02615 http://www.genome.jp/dbget-bin/www_bget?KO:K02615 KEGG_Pathway ko00360 http://www.genome.jp/kegg-bin/show_pathway?ko00360 KEGG_Reaction rn:R00829 http://www.genome.jp/dbget-bin/www_bget?rn:R00829 KEGG_Reaction rn:R09839 http://www.genome.jp/dbget-bin/www_bget?rn:R09839 OMA AVPPRIM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AVPPRIM PROSITE PS00098 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00098 PROSITE PS00099 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00099 PROSITE PS00737 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00737 PSORT swissprot:PAAJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PAAJ_ECOLI PSORT-B swissprot:PAAJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PAAJ_ECOLI PSORT2 swissprot:PAAJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PAAJ_ECOLI Pfam PF00108 http://pfam.xfam.org/family/PF00108 Pfam PF02803 http://pfam.xfam.org/family/PF02803 Phobius swissprot:PAAJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PAAJ_ECOLI PhylomeDB P0C7L2 http://phylomedb.org/?seqid=P0C7L2 ProteinModelPortal P0C7L2 http://www.proteinmodelportal.org/query/uniprot/P0C7L2 PubMed 10766858 http://www.ncbi.nlm.nih.gov/pubmed/10766858 PubMed 12846838 http://www.ncbi.nlm.nih.gov/pubmed/12846838 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17259607 http://www.ncbi.nlm.nih.gov/pubmed/17259607 PubMed 20660314 http://www.ncbi.nlm.nih.gov/pubmed/20660314 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9748275 http://www.ncbi.nlm.nih.gov/pubmed/9748275 RefSeq NP_415915 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415915 RefSeq WP_001206197 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001206197 SMR P0C7L2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0C7L2 STRING 511145.b1397 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1397&targetmode=cogs STRING COG0183 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0183&targetmode=cogs SUPFAM SSF53901 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53901 TIGRFAMs TIGR01930 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01930 TIGRFAMs TIGR02430 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02430 UniProtKB PAAJ_ECOLI http://www.uniprot.org/uniprot/PAAJ_ECOLI UniProtKB-AC P0C7L2 http://www.uniprot.org/uniprot/P0C7L2 charge swissprot:PAAJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PAAJ_ECOLI eggNOG COG0183 http://eggnogapi.embl.de/nog_data/html/tree/COG0183 eggNOG ENOG4105CHU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CHU epestfind swissprot:PAAJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PAAJ_ECOLI garnier swissprot:PAAJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PAAJ_ECOLI helixturnhelix swissprot:PAAJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PAAJ_ECOLI hmoment swissprot:PAAJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PAAJ_ECOLI iep swissprot:PAAJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PAAJ_ECOLI inforesidue swissprot:PAAJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PAAJ_ECOLI octanol swissprot:PAAJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PAAJ_ECOLI pepcoil swissprot:PAAJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PAAJ_ECOLI pepdigest swissprot:PAAJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PAAJ_ECOLI pepinfo swissprot:PAAJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PAAJ_ECOLI pepnet swissprot:PAAJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PAAJ_ECOLI pepstats swissprot:PAAJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PAAJ_ECOLI pepwheel swissprot:PAAJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PAAJ_ECOLI pepwindow swissprot:PAAJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PAAJ_ECOLI sigcleave swissprot:PAAJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PAAJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4262027 210 # EcoGene EG12081 ppdA # FUNCTION PPDA_ECOLI Not yet known. # InterPro IPR012902 N_methyl_site # KEGG_Brite ko02044 Secretion system # Organism PPDA_ECOLI Escherichia coli (strain K12) # PATRIC 32121070 VBIEscCol129921_2924 # PIR C65065 C65065 # PROSITE PS00409 PROKAR_NTER_METHYL # Pfam PF07963 N_methyl # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PPDA_ECOLI Prepilin peptidase-dependent protein A # RefSeq NP_417303 NC_000913.3 # RefSeq WP_000857051 NZ_LN832404.1 # TIGRFAMs TIGR02532 IV_pilin_GFxxxE # eggNOG COG2165 LUCA # eggNOG ENOG4105IPU Bacteria BLAST swissprot:PPDA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PPDA_ECOLI BioCyc ECOL316407:JW2794-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2794-MONOMER BioCyc EcoCyc:EG12081-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12081-MONOMER COG COG2165 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2165 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/14.11.4437 http://dx.doi.org/10.1093/nar/14.11.4437 DOI 10.1111/j.1365-2958.1993.tb01949.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb01949.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 EMBL X03966 http://www.ebi.ac.uk/ena/data/view/X03966 EchoBASE EB2006 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2006 EcoGene EG12081 http://www.ecogene.org/geneInfo.php?eg_id=EG12081 EnsemblBacteria AAC75865 http://www.ensemblgenomes.org/id/AAC75865 EnsemblBacteria AAC75865 http://www.ensemblgenomes.org/id/AAC75865 EnsemblBacteria BAE76895 http://www.ensemblgenomes.org/id/BAE76895 EnsemblBacteria BAE76895 http://www.ensemblgenomes.org/id/BAE76895 EnsemblBacteria BAE76895 http://www.ensemblgenomes.org/id/BAE76895 EnsemblBacteria b2826 http://www.ensemblgenomes.org/id/b2826 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945393 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945393 HOGENOM HOG000124358 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000124358&db=HOGENOM6 InterPro IPR012902 http://www.ebi.ac.uk/interpro/entry/IPR012902 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW2794 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2794 KEGG_Gene eco:b2826 http://www.genome.jp/dbget-bin/www_bget?eco:b2826 KEGG_Orthology KO:K02679 http://www.genome.jp/dbget-bin/www_bget?KO:K02679 OMA HWGRIRL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HWGRIRL PROSITE PS00409 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00409 PSORT swissprot:PPDA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PPDA_ECOLI PSORT-B swissprot:PPDA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PPDA_ECOLI PSORT2 swissprot:PPDA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PPDA_ECOLI Pfam PF07963 http://pfam.xfam.org/family/PF07963 Phobius swissprot:PPDA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PPDA_ECOLI ProteinModelPortal P33554 http://www.proteinmodelportal.org/query/uniprot/P33554 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3520484 http://www.ncbi.nlm.nih.gov/pubmed/3520484 PubMed 7934814 http://www.ncbi.nlm.nih.gov/pubmed/7934814 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417303 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417303 RefSeq WP_000857051 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000857051 SMR P33554 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33554 STRING 511145.b2826 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2826&targetmode=cogs STRING COG2165 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2165&targetmode=cogs TIGRFAMs TIGR02532 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02532 UniProtKB PPDA_ECOLI http://www.uniprot.org/uniprot/PPDA_ECOLI UniProtKB-AC P33554 http://www.uniprot.org/uniprot/P33554 charge swissprot:PPDA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PPDA_ECOLI eggNOG COG2165 http://eggnogapi.embl.de/nog_data/html/tree/COG2165 eggNOG ENOG4105IPU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105IPU epestfind swissprot:PPDA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PPDA_ECOLI garnier swissprot:PPDA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PPDA_ECOLI helixturnhelix swissprot:PPDA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PPDA_ECOLI hmoment swissprot:PPDA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PPDA_ECOLI iep swissprot:PPDA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PPDA_ECOLI inforesidue swissprot:PPDA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PPDA_ECOLI octanol swissprot:PPDA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PPDA_ECOLI pepcoil swissprot:PPDA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PPDA_ECOLI pepdigest swissprot:PPDA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PPDA_ECOLI pepinfo swissprot:PPDA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PPDA_ECOLI pepnet swissprot:PPDA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PPDA_ECOLI pepstats swissprot:PPDA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PPDA_ECOLI pepwheel swissprot:PPDA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PPDA_ECOLI pepwindow swissprot:PPDA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PPDA_ECOLI sigcleave swissprot:PPDA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PPDA_ECOLI ## Database ID URL or Descriptions # FUNCTION TRAJ1_ECOLI This protein is essential for positively regulating the expression of transfer genes that are involved in the conjugal transfer of DNA between bacterial cells. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_process GO:0000746 conjugation; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR016032 Sig_transdc_resp-reg_C-effctor # InterPro IPR016383 TraJ # Organism TRAJ1_ECOLI Escherichia coli (strain K12) # PDB 4KQD X-ray; 1.55 A; A/B/C/D=14-133 # PIR A21874 BVECTJ # PIRSF PIRSF003267 TraJ_F # RecName TRAJ1_ECOLI Protein TraJ # RefSeq NP_061451 NC_002483.1 # RefSeq NP_862917 NC_004998.1 # RefSeq WP_000283385 NZ_CP014273.1 # RefSeq YP_003937615 NC_014615.1 # RefSeq YP_009060158 NC_024956.1 # RefSeq YP_009068353 NC_025139.1 # RefSeq YP_009070618 NC_025175.1 # RefSeq YP_009071228 NC_025179.1 # SUBCELLULAR LOCATION TRAJ1_ECOLI Cytoplasm {ECO 0000250}. # SUPFAM SSF46894 SSF46894 BLAST swissprot:TRAJ1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRAJ1_ECOLI DOI 10.1007/BF00330058 http://dx.doi.org/10.1007/BF00330058 DOI 10.1016/0378-1119(83)90038-0 http://dx.doi.org/10.1016/0378-1119(83)90038-0 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL K01147 http://www.ebi.ac.uk/ena/data/view/K01147 EMBL U01159 http://www.ebi.ac.uk/ena/data/view/U01159 EMBL X00545 http://www.ebi.ac.uk/ena/data/view/X00545 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0000746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000746 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 1263572 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263572 GeneID 1446481 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1446481 GeneID 20466908 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20466908 GeneID 20491483 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20491483 GeneID 20492686 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20492686 GeneID 20493300 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20493300 GeneID 9846155 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9846155 IntAct P06626 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P06626* InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR016032 http://www.ebi.ac.uk/interpro/entry/IPR016032 InterPro IPR016383 http://www.ebi.ac.uk/interpro/entry/IPR016383 OMA FIHYLYE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FIHYLYE PDB 4KQD http://www.ebi.ac.uk/pdbe-srv/view/entry/4KQD PDBsum 4KQD http://www.ebi.ac.uk/pdbsum/4KQD PSORT swissprot:TRAJ1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRAJ1_ECOLI PSORT-B swissprot:TRAJ1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRAJ1_ECOLI PSORT2 swissprot:TRAJ1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRAJ1_ECOLI Phobius swissprot:TRAJ1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRAJ1_ECOLI ProteinModelPortal P06626 http://www.proteinmodelportal.org/query/uniprot/P06626 PubMed 6298579 http://www.ncbi.nlm.nih.gov/pubmed/6298579 PubMed 6368316 http://www.ncbi.nlm.nih.gov/pubmed/6368316 PubMed 7915817 http://www.ncbi.nlm.nih.gov/pubmed/7915817 RefSeq NP_061451 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061451 RefSeq NP_862917 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_862917 RefSeq WP_000283385 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000283385 RefSeq YP_003937615 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_003937615 RefSeq YP_009060158 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009060158 RefSeq YP_009068353 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009068353 RefSeq YP_009070618 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009070618 RefSeq YP_009071228 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009071228 SMR P06626 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P06626 SUPFAM SSF46894 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46894 UniProtKB TRAJ1_ECOLI http://www.uniprot.org/uniprot/TRAJ1_ECOLI UniProtKB-AC P06626 http://www.uniprot.org/uniprot/P06626 charge swissprot:TRAJ1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRAJ1_ECOLI epestfind swissprot:TRAJ1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRAJ1_ECOLI garnier swissprot:TRAJ1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRAJ1_ECOLI helixturnhelix swissprot:TRAJ1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRAJ1_ECOLI hmoment swissprot:TRAJ1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRAJ1_ECOLI iep swissprot:TRAJ1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRAJ1_ECOLI inforesidue swissprot:TRAJ1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRAJ1_ECOLI octanol swissprot:TRAJ1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRAJ1_ECOLI pepcoil swissprot:TRAJ1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRAJ1_ECOLI pepdigest swissprot:TRAJ1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRAJ1_ECOLI pepinfo swissprot:TRAJ1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRAJ1_ECOLI pepnet swissprot:TRAJ1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRAJ1_ECOLI pepstats swissprot:TRAJ1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRAJ1_ECOLI pepwheel swissprot:TRAJ1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRAJ1_ECOLI pepwindow swissprot:TRAJ1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRAJ1_ECOLI sigcleave swissprot:TRAJ1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRAJ1_ECOLI ## Database ID URL or Descriptions # AltName NARH_ECOLI Nitrate reductase A subunit beta # AltName NARH_ECOLI Quinol-nitrate oxidoreductase subunit beta # BRENDA 1.7.5 2026 # BioGrid 4262231 20 # CATALYTIC ACTIVITY NARH_ECOLI Nitrite + acceptor = nitrate + reduced acceptor. # COFACTOR NARH_ECOLI Name=[3Fe-4S] cluster; Xref=ChEBI CHEBI 21137; Evidence={ECO 0000269|PubMed 12910261, ECO 0000269|PubMed 14725769}; Note=Binds 1 [3Fe-4S] cluster per subunit. {ECO 0000269|PubMed 12910261, ECO 0000269|PubMed 14725769}; # COFACTOR NARH_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000269|PubMed 12910261, ECO 0000269|PubMed 14725769}; Note=Binds 3 [4Fe-4S] clusters per subunit. {ECO 0000269|PubMed 12910261, ECO 0000269|PubMed 14725769}; # EcoGene EG10639 narH # FUNCTION NARH_ECOLI The nitrate reductase enzyme complex allows E.coli to use nitrate as an electron acceptor during anaerobic growth. The beta chain is an electron transfer unit containing four cysteine clusters involved in the formation of iron-sulfur centers. Electrons are transferred from the gamma chain to the molybdenum cofactor of the alpha subunit. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_component GO:0031224 intrinsic component of membrane; IDA:EcoCyc. # GO_component GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane; IDA:EcoCyc. # GO_component GO:0044799 NarGHI complex; IDA:EcoCyc. # GO_function GO:0008940 nitrate reductase activity; IMP:EcoCyc. # GO_function GO:0009055 electron carrier activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051538 3 iron, 4 sulfur cluster binding; IDA:EcoCyc. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IDA:EcoCyc. # GO_process GO:0009061 anaerobic respiration; IEP:EcoCyc. # GO_process GO:0042126 nitrate metabolic process; IMP:EcoCyc. # GO_process GO:0042128 nitrate assimilation; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0071941 nitrogen cycle metabolic process # Gene3D 1.10.3650.10 -; 1. # INDUCTION NARH_ECOLI By nitrate. # INTERACTION NARH_ECOLI P09152 narG; NbExp=11; IntAct=EBI-555067, EBI-547248; P19319 narZ; NbExp=4; IntAct=EBI-555067, EBI-547262; # IntAct P11349 13 # InterPro IPR006547 NO3_Rdtase_bsu # InterPro IPR017896 4Fe4S_Fe-S-bd # InterPro IPR029263 Nitr_red_bet_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00910 Nitrogen metabolism # KEGG_Pathway ko02020 Two-component system # Organism NARH_ECOLI Escherichia coli (strain K12) # PATRIC 32117710 VBIEscCol129921_1277 # PDB 1Q16 X-ray; 1.90 A; B=1-512 # PDB 1R27 X-ray; 2.00 A; B/D=1-512 # PDB 1SIW X-ray; 2.20 A; B=1-512 # PDB 1Y4Z X-ray; 2.00 A; B=1-512 # PDB 1Y5I X-ray; 1.90 A; B=1-512 # PDB 1Y5L X-ray; 2.50 A; B=1-512 # PDB 1Y5N X-ray; 2.50 A; B=1-512 # PDB 3EGW X-ray; 1.90 A; B=1-509 # PDB 3IR5 X-ray; 2.30 A; B=1-512 # PDB 3IR6 X-ray; 2.80 A; B=1-512 # PDB 3IR7 X-ray; 2.50 A; B=1-512 # PIR F64869 RDECNB # PROSITE PS51379 4FE4S_FER_2; 3 # Pfam PF13247 Fer4_11 # Pfam PF14711 Nitr_red_bet_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NARH_ECOLI Respiratory nitrate reductase 1 beta chain # RefSeq NP_415743 NC_000913.3 # RefSeq WP_000702650 NZ_LN832404.1 # SIMILARITY Contains 3 4Fe-4S ferredoxin-type domains. {ECO:0000255|PROSITE-ProRule PRU00711}. # SUBCELLULAR LOCATION NARH_ECOLI Cell membrane; Peripheral membrane protein. # SUBUNIT Dimer of heterotrimers each composed of an alpha, a beta and a gamma chain. Alpha and beta are catalytic chains; gamma chains are involved in binding the enzyme complex to the cytoplasmic membrane. {ECO:0000269|PubMed 12910261}. # TCDB 5.A.3.1 the prokaryotic molybdopterin-containing oxidoreductase (pmo) family # TIGRFAMs TIGR01660 narH # WEB RESOURCE NARH_ECOLI Name=Worthington enzyme manual; URL="http //www.worthington-biochem.com/NAR/"; # eggNOG COG1140 LUCA # eggNOG ENOG4108IUE Bacteria BLAST swissprot:NARH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NARH_ECOLI BioCyc ECOL316407:JW1216-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1216-MONOMER BioCyc EcoCyc:NARH-MONOMER http://biocyc.org/getid?id=EcoCyc:NARH-MONOMER BioCyc MetaCyc:NARH-MONOMER http://biocyc.org/getid?id=MetaCyc:NARH-MONOMER COG COG1140 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1140 DIP DIP-10312N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10312N DOI 10.1007/BF00331275 http://dx.doi.org/10.1007/BF00331275 DOI 10.1016/j.str.2003.11.020 http://dx.doi.org/10.1016/j.str.2003.11.020 DOI 10.1021/bi00059a018 http://dx.doi.org/10.1021/bi00059a018 DOI 10.1021/bi00070a018 http://dx.doi.org/10.1021/bi00070a018 DOI 10.1021/bi952459p http://dx.doi.org/10.1021/bi952459p DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb969 http://dx.doi.org/10.1038/nsb969 DOI 10.1074/jbc.273.13.7462 http://dx.doi.org/10.1074/jbc.273.13.7462 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1432-1033.1992.tb17020.x http://dx.doi.org/10.1111/j.1432-1033.1992.tb17020.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.7.99.4 http://www.genome.jp/dbget-bin/www_bget?EC:1.7.99.4 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M20147 http://www.ebi.ac.uk/ena/data/view/M20147 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X16181 http://www.ebi.ac.uk/ena/data/view/X16181 ENZYME 1.7.99.4 http://enzyme.expasy.org/EC/1.7.99.4 EchoBASE EB0633 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0633 EcoGene EG10639 http://www.ecogene.org/geneInfo.php?eg_id=EG10639 EnsemblBacteria AAC74309 http://www.ensemblgenomes.org/id/AAC74309 EnsemblBacteria AAC74309 http://www.ensemblgenomes.org/id/AAC74309 EnsemblBacteria BAA36095 http://www.ensemblgenomes.org/id/BAA36095 EnsemblBacteria BAA36095 http://www.ensemblgenomes.org/id/BAA36095 EnsemblBacteria BAA36095 http://www.ensemblgenomes.org/id/BAA36095 EnsemblBacteria b1225 http://www.ensemblgenomes.org/id/b1225 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0031224 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031224 GO_component GO:0031235 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031235 GO_component GO:0044799 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044799 GO_function GO:0008940 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008940 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051538 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051538 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0009061 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009061 GO_process GO:0042126 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042126 GO_process GO:0042128 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042128 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0071941 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071941 Gene3D 1.10.3650.10 http://www.cathdb.info/version/latest/superfamily/1.10.3650.10 GeneID 945780 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945780 HOGENOM HOG000237353 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000237353&db=HOGENOM6 InParanoid P11349 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P11349 IntAct P11349 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P11349* IntEnz 1.7.99.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.7.99.4 InterPro IPR006547 http://www.ebi.ac.uk/interpro/entry/IPR006547 InterPro IPR017896 http://www.ebi.ac.uk/interpro/entry/IPR017896 InterPro IPR029263 http://www.ebi.ac.uk/interpro/entry/IPR029263 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1216 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1216 KEGG_Gene eco:b1225 http://www.genome.jp/dbget-bin/www_bget?eco:b1225 KEGG_Orthology KO:K00371 http://www.genome.jp/dbget-bin/www_bget?KO:K00371 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 KEGG_Reaction rn:R00798 http://www.genome.jp/dbget-bin/www_bget?rn:R00798 KEGG_Reaction rn:R01106 http://www.genome.jp/dbget-bin/www_bget?rn:R01106 MINT MINT-1260007 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1260007 OMA QSPIYKM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QSPIYKM PDB 1Q16 http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q16 PDB 1R27 http://www.ebi.ac.uk/pdbe-srv/view/entry/1R27 PDB 1SIW http://www.ebi.ac.uk/pdbe-srv/view/entry/1SIW PDB 1Y4Z http://www.ebi.ac.uk/pdbe-srv/view/entry/1Y4Z PDB 1Y5I http://www.ebi.ac.uk/pdbe-srv/view/entry/1Y5I PDB 1Y5L http://www.ebi.ac.uk/pdbe-srv/view/entry/1Y5L PDB 1Y5N http://www.ebi.ac.uk/pdbe-srv/view/entry/1Y5N PDB 3EGW http://www.ebi.ac.uk/pdbe-srv/view/entry/3EGW PDB 3IR5 http://www.ebi.ac.uk/pdbe-srv/view/entry/3IR5 PDB 3IR6 http://www.ebi.ac.uk/pdbe-srv/view/entry/3IR6 PDB 3IR7 http://www.ebi.ac.uk/pdbe-srv/view/entry/3IR7 PDBsum 1Q16 http://www.ebi.ac.uk/pdbsum/1Q16 PDBsum 1R27 http://www.ebi.ac.uk/pdbsum/1R27 PDBsum 1SIW http://www.ebi.ac.uk/pdbsum/1SIW PDBsum 1Y4Z http://www.ebi.ac.uk/pdbsum/1Y4Z PDBsum 1Y5I http://www.ebi.ac.uk/pdbsum/1Y5I PDBsum 1Y5L http://www.ebi.ac.uk/pdbsum/1Y5L PDBsum 1Y5N http://www.ebi.ac.uk/pdbsum/1Y5N PDBsum 3EGW http://www.ebi.ac.uk/pdbsum/3EGW PDBsum 3IR5 http://www.ebi.ac.uk/pdbsum/3IR5 PDBsum 3IR6 http://www.ebi.ac.uk/pdbsum/3IR6 PDBsum 3IR7 http://www.ebi.ac.uk/pdbsum/3IR7 PROSITE PS51379 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51379 PSORT swissprot:NARH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NARH_ECOLI PSORT-B swissprot:NARH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NARH_ECOLI PSORT2 swissprot:NARH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NARH_ECOLI Pfam PF13247 http://pfam.xfam.org/family/PF13247 Pfam PF14711 http://pfam.xfam.org/family/PF14711 Phobius swissprot:NARH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NARH_ECOLI PhylomeDB P11349 http://phylomedb.org/?seqid=P11349 ProteinModelPortal P11349 http://www.proteinmodelportal.org/query/uniprot/P11349 PubMed 12910261 http://www.ncbi.nlm.nih.gov/pubmed/12910261 PubMed 1321049 http://www.ncbi.nlm.nih.gov/pubmed/1321049 PubMed 14725769 http://www.ncbi.nlm.nih.gov/pubmed/14725769 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2674654 http://www.ncbi.nlm.nih.gov/pubmed/2674654 PubMed 2832376 http://www.ncbi.nlm.nih.gov/pubmed/2832376 PubMed 3053688 http://www.ncbi.nlm.nih.gov/pubmed/3053688 PubMed 8383531 http://www.ncbi.nlm.nih.gov/pubmed/8383531 PubMed 8388253 http://www.ncbi.nlm.nih.gov/pubmed/8388253 PubMed 8664273 http://www.ncbi.nlm.nih.gov/pubmed/8664273 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9516445 http://www.ncbi.nlm.nih.gov/pubmed/9516445 RefSeq NP_415743 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415743 RefSeq WP_000702650 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000702650 SMR P11349 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P11349 STRING 511145.b1225 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1225&targetmode=cogs STRING COG1140 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1140&targetmode=cogs TCDB 5.A.3.1 http://www.tcdb.org/search/result.php?tc=5.A.3.1 TIGRFAMs TIGR01660 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01660 UniProtKB NARH_ECOLI http://www.uniprot.org/uniprot/NARH_ECOLI UniProtKB-AC P11349 http://www.uniprot.org/uniprot/P11349 charge swissprot:NARH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NARH_ECOLI eggNOG COG1140 http://eggnogapi.embl.de/nog_data/html/tree/COG1140 eggNOG ENOG4108IUE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108IUE epestfind swissprot:NARH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NARH_ECOLI garnier swissprot:NARH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NARH_ECOLI helixturnhelix swissprot:NARH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NARH_ECOLI hmoment swissprot:NARH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NARH_ECOLI iep swissprot:NARH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NARH_ECOLI inforesidue swissprot:NARH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NARH_ECOLI octanol swissprot:NARH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NARH_ECOLI pepcoil swissprot:NARH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NARH_ECOLI pepdigest swissprot:NARH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NARH_ECOLI pepinfo swissprot:NARH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NARH_ECOLI pepnet swissprot:NARH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NARH_ECOLI pepstats swissprot:NARH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NARH_ECOLI pepwheel swissprot:NARH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NARH_ECOLI pepwindow swissprot:NARH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NARH_ECOLI sigcleave swissprot:NARH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NARH_ECOLI ## Database ID URL or Descriptions # AltName MALQ_ECOLI Amylomaltase # AltName MALQ_ECOLI Disproportionating enzyme # BioGrid 4261216 124 # CATALYTIC ACTIVITY MALQ_ECOLI Transfers a segment of a (1->4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1->4)-alpha-D-glucan. # CAZy GH77 Glycoside Hydrolase Family 77 # EcoGene EG10561 malQ # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004134 4-alpha-glucanotransferase activity; IDA:EcoCyc. # GO_process GO:0000025 maltose catabolic process; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # Gene3D 3.20.20.80 -; 2. # IntAct P15977 6 # InterPro IPR003385 Glyco_hydro_77 # InterPro IPR013781 Glyco_hydro_catalytic_dom # InterPro IPR017853 Glycoside_hydrolase_SF # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00500 Starch and sucrose metabolism # Organism MALQ_ECOLI Escherichia coli (strain K12) # PATRIC 32122270 VBIEscCol129921_3512 # PDB 4S3P X-ray; 2.80 A; A/B=1-688 # PDB 4S3Q X-ray; 2.10 A; A/B/C=1-688 # PDB 4S3R X-ray; 2.10 A; A=1-688 # PIR C65137 C65137 # Pfam PF02446 Glyco_hydro_77 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MALQ_ECOLI 4-alpha-glucanotransferase # RefSeq NP_417875 NC_000913.3 # RefSeq WP_000444342 NZ_LN832404.1 # SIMILARITY Belongs to the disproportionating enzyme family. {ECO 0000305}. # SUBCELLULAR LOCATION MALQ_ECOLI Cytoplasm. # SUPFAM SSF51445 SSF51445; 2 # TIGRFAMs TIGR00217 malQ # eggNOG COG1640 LUCA # eggNOG ENOG4107RTM Bacteria BLAST swissprot:MALQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MALQ_ECOLI BioCyc ECOL316407:JW3379-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3379-MONOMER BioCyc EcoCyc:AMYLOMALT-MONOMER http://biocyc.org/getid?id=EcoCyc:AMYLOMALT-MONOMER BioCyc MetaCyc:AMYLOMALT-MONOMER http://biocyc.org/getid?id=MetaCyc:AMYLOMALT-MONOMER COG COG1640 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1640 DIP DIP-10147N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10147N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1988.tb00053.x http://dx.doi.org/10.1111/j.1365-2958.1988.tb00053.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.4.1.25 http://www.genome.jp/dbget-bin/www_bget?EC:2.4.1.25 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M32793 http://www.ebi.ac.uk/ena/data/view/M32793 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 2.4.1.25 http://enzyme.expasy.org/EC/2.4.1.25 EchoBASE EB0556 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0556 EcoGene EG10561 http://www.ecogene.org/geneInfo.php?eg_id=EG10561 EnsemblBacteria AAC76441 http://www.ensemblgenomes.org/id/AAC76441 EnsemblBacteria AAC76441 http://www.ensemblgenomes.org/id/AAC76441 EnsemblBacteria BAE77875 http://www.ensemblgenomes.org/id/BAE77875 EnsemblBacteria BAE77875 http://www.ensemblgenomes.org/id/BAE77875 EnsemblBacteria BAE77875 http://www.ensemblgenomes.org/id/BAE77875 EnsemblBacteria b3416 http://www.ensemblgenomes.org/id/b3416 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004134 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004134 GO_process GO:0000025 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000025 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 3.20.20.80 http://www.cathdb.info/version/latest/superfamily/3.20.20.80 GeneID 947923 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947923 HOGENOM HOG000245168 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000245168&db=HOGENOM6 InParanoid P15977 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P15977 IntAct P15977 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P15977* IntEnz 2.4.1.25 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.1.25 InterPro IPR003385 http://www.ebi.ac.uk/interpro/entry/IPR003385 InterPro IPR013781 http://www.ebi.ac.uk/interpro/entry/IPR013781 InterPro IPR017853 http://www.ebi.ac.uk/interpro/entry/IPR017853 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3379 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3379 KEGG_Gene eco:b3416 http://www.genome.jp/dbget-bin/www_bget?eco:b3416 KEGG_Orthology KO:K00705 http://www.genome.jp/dbget-bin/www_bget?KO:K00705 KEGG_Pathway ko00500 http://www.genome.jp/kegg-bin/show_pathway?ko00500 KEGG_Reaction rn:R05196 http://www.genome.jp/dbget-bin/www_bget?rn:R05196 MINT MINT-1275716 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1275716 OMA WSRQDEL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WSRQDEL PDB 4S3P http://www.ebi.ac.uk/pdbe-srv/view/entry/4S3P PDB 4S3Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4S3Q PDB 4S3R http://www.ebi.ac.uk/pdbe-srv/view/entry/4S3R PDBsum 4S3P http://www.ebi.ac.uk/pdbsum/4S3P PDBsum 4S3Q http://www.ebi.ac.uk/pdbsum/4S3Q PDBsum 4S3R http://www.ebi.ac.uk/pdbsum/4S3R PSORT swissprot:MALQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MALQ_ECOLI PSORT-B swissprot:MALQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MALQ_ECOLI PSORT2 swissprot:MALQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MALQ_ECOLI Pfam PF02446 http://pfam.xfam.org/family/PF02446 Phobius swissprot:MALQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MALQ_ECOLI PhylomeDB P15977 http://phylomedb.org/?seqid=P15977 ProteinModelPortal P15977 http://www.proteinmodelportal.org/query/uniprot/P15977 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2845225 http://www.ncbi.nlm.nih.gov/pubmed/2845225 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417875 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417875 RefSeq WP_000444342 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000444342 SMR P15977 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P15977 STRING 511145.b3416 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3416&targetmode=cogs STRING COG1640 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1640&targetmode=cogs SUPFAM SSF51445 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51445 TIGRFAMs TIGR00217 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00217 UniProtKB MALQ_ECOLI http://www.uniprot.org/uniprot/MALQ_ECOLI UniProtKB-AC P15977 http://www.uniprot.org/uniprot/P15977 charge swissprot:MALQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MALQ_ECOLI eggNOG COG1640 http://eggnogapi.embl.de/nog_data/html/tree/COG1640 eggNOG ENOG4107RTM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107RTM epestfind swissprot:MALQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MALQ_ECOLI garnier swissprot:MALQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MALQ_ECOLI helixturnhelix swissprot:MALQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MALQ_ECOLI hmoment swissprot:MALQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MALQ_ECOLI iep swissprot:MALQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MALQ_ECOLI inforesidue swissprot:MALQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MALQ_ECOLI octanol swissprot:MALQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MALQ_ECOLI pepcoil swissprot:MALQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MALQ_ECOLI pepdigest swissprot:MALQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MALQ_ECOLI pepinfo swissprot:MALQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MALQ_ECOLI pepnet swissprot:MALQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MALQ_ECOLI pepstats swissprot:MALQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MALQ_ECOLI pepwheel swissprot:MALQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MALQ_ECOLI pepwindow swissprot:MALQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MALQ_ECOLI sigcleave swissprot:MALQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MALQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4260314 18 # CDD cd01949 GGDEF # EcoGene EG13495 yeaI # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:1902201 negative regulation of bacterial-type flagellum-dependent cell motility; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0008150 biological_process # INDUCTION Induced by 0.3M NaCl in an RpoS-dependent fashion. {ECO:0000269|PubMed 17010156}. # IntAct P76236 2 # InterPro IPR000160 GGDEF_dom # InterPro IPR029787 Nucleotide_cyclase # InterPro IPR033424 MASE4 # Organism YEAI_ECOLI Escherichia coli (strain K12) # PATRIC 32118881 VBIEscCol129921_1858 # PIR A64939 A64939 # PROSITE PS50887 GGDEF # Pfam PF00990 GGDEF # Pfam PF17158 MASE4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEAI_ECOLI Inner membrane protein YeaI # RefSeq NP_416299 NC_000913.3 # SIMILARITY Contains 1 GGDEF domain. {ECO:0000255|PROSITE- ProRule PRU00095}. # SMART SM00267 GGDEF # SUBCELLULAR LOCATION YEAI_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF55073 SSF55073 # TIGRFAMs TIGR00254 GGDEF # eggNOG COG2199 LUCA # eggNOG ENOG4106KTS Bacteria BLAST swissprot:YEAI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEAI_ECOLI BioCyc ECOL316407:JW1774-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1774-MONOMER BioCyc EcoCyc:G6971-MONOMER http://biocyc.org/getid?id=EcoCyc:G6971-MONOMER DIP DIP-11788N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11788N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1111/j.1365-2958.2006.05440.x http://dx.doi.org/10.1111/j.1365-2958.2006.05440.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3268 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3268 EcoGene EG13495 http://www.ecogene.org/geneInfo.php?eg_id=EG13495 EnsemblBacteria AAC74855 http://www.ensemblgenomes.org/id/AAC74855 EnsemblBacteria AAC74855 http://www.ensemblgenomes.org/id/AAC74855 EnsemblBacteria BAA15586 http://www.ensemblgenomes.org/id/BAA15586 EnsemblBacteria BAA15586 http://www.ensemblgenomes.org/id/BAA15586 EnsemblBacteria BAA15586 http://www.ensemblgenomes.org/id/BAA15586 EnsemblBacteria b1785 http://www.ensemblgenomes.org/id/b1785 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:1902201 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902201 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 946366 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946366 HOGENOM HOG000118907 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118907&db=HOGENOM6 InParanoid P76236 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76236 IntAct P76236 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76236* InterPro IPR000160 http://www.ebi.ac.uk/interpro/entry/IPR000160 InterPro IPR029787 http://www.ebi.ac.uk/interpro/entry/IPR029787 InterPro IPR033424 http://www.ebi.ac.uk/interpro/entry/IPR033424 KEGG_Gene ecj:JW1774 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1774 KEGG_Gene eco:b1785 http://www.genome.jp/dbget-bin/www_bget?eco:b1785 MINT MINT-1232043 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1232043 OMA SHAYLME http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SHAYLME PROSITE PS50887 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50887 PSORT swissprot:YEAI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEAI_ECOLI PSORT-B swissprot:YEAI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEAI_ECOLI PSORT2 swissprot:YEAI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEAI_ECOLI Pfam PF00990 http://pfam.xfam.org/family/PF00990 Pfam PF17158 http://pfam.xfam.org/family/PF17158 Phobius swissprot:YEAI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEAI_ECOLI ProteinModelPortal P76236 http://www.proteinmodelportal.org/query/uniprot/P76236 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17010156 http://www.ncbi.nlm.nih.gov/pubmed/17010156 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416299 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416299 SMART SM00267 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00267 SMR P76236 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76236 STRING 511145.b1785 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1785&targetmode=cogs SUPFAM SSF55073 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55073 TIGRFAMs TIGR00254 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00254 UniProtKB YEAI_ECOLI http://www.uniprot.org/uniprot/YEAI_ECOLI UniProtKB-AC P76236 http://www.uniprot.org/uniprot/P76236 charge swissprot:YEAI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEAI_ECOLI eggNOG COG2199 http://eggnogapi.embl.de/nog_data/html/tree/COG2199 eggNOG ENOG4106KTS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106KTS epestfind swissprot:YEAI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEAI_ECOLI garnier swissprot:YEAI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEAI_ECOLI helixturnhelix swissprot:YEAI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEAI_ECOLI hmoment swissprot:YEAI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEAI_ECOLI iep swissprot:YEAI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEAI_ECOLI inforesidue swissprot:YEAI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEAI_ECOLI octanol swissprot:YEAI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEAI_ECOLI pepcoil swissprot:YEAI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEAI_ECOLI pepdigest swissprot:YEAI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEAI_ECOLI pepinfo swissprot:YEAI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEAI_ECOLI pepnet swissprot:YEAI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEAI_ECOLI pepstats swissprot:YEAI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEAI_ECOLI pepwheel swissprot:YEAI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEAI_ECOLI pepwindow swissprot:YEAI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEAI_ECOLI sigcleave swissprot:YEAI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEAI_ECOLI ## Database ID URL or Descriptions # AltName SYFA_ECOLI Phenylalanyl-tRNA synthetase alpha subunit # BioGrid 4260287 194 # CATALYTIC ACTIVITY SYFA_ECOLI ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). # COFACTOR SYFA_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250}; Note=Binds 2 magnesium ions per tetramer. {ECO 0000250}; # EcoGene EG10709 pheS # GO_component GO:0005737 cytoplasm; IDA:UniProtKB. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0009328 phenylalanine-tRNA ligase complex; IDA:EcoCyc. # GO_function GO:0000049 tRNA binding; IEA:InterPro. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0004826 phenylalanine-tRNA ligase activity; IBA:GO_Central. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006432 phenylalanyl-tRNA aminoacylation; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0006520 cellular amino acid metabolic process # HAMAP MF_00281 Phe_tRNA_synth_alpha1 # INTERACTION SYFA_ECOLI P0AD99 brnQ; NbExp=3; IntAct=EBI-555676, EBI-555687; P39176 erfK; NbExp=3; IntAct=EBI-555676, EBI-555707; P07395 pheT; NbExp=7; IntAct=EBI-555676, EBI-555713; # IntAct P08312 7 # InterPro IPR002319 Phenylalanyl-tRNA_Synthase # InterPro IPR004188 Phe-tRNA_ligase_II_N # InterPro IPR004529 Phe-tRNA-synth_IIc_asu # InterPro IPR006195 aa-tRNA-synth_II # InterPro IPR010978 tRNA-bd_arm # InterPro IPR022911 Phe_tRNA_ligase_alpha1_bac # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01007 Amino acid related enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # KEGG_Pathway ko00970 Aminoacyl-tRNA biosynthesis # Organism SYFA_ECOLI Escherichia coli (strain K12) # PATRIC 32118734 VBIEscCol129921_1785 # PDB 3PCO X-ray; 3.02 A; A/C=1-327 # PIR B64930 SYECFA # PROSITE PS50862 AA_TRNA_LIGASE_II # Pfam PF01409 tRNA-synt_2d # Pfam PF02912 Phe_tRNA-synt_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SYFA_ECOLI Phenylalanine--tRNA ligase alpha subunit # RefSeq NP_416229 NC_000913.3 # RefSeq WP_000018596 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA23564.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION SYFA_ECOLI Cytoplasm. # SUBUNIT SYFA_ECOLI Tetramer of two alpha and two beta subunits. # SUPFAM SSF46589 SSF46589 # TIGRFAMs TIGR00468 pheS # eggNOG COG0016 LUCA # eggNOG ENOG4105CSS Bacteria BLAST swissprot:SYFA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SYFA_ECOLI BioCyc ECOL316407:JW5277-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5277-MONOMER BioCyc EcoCyc:PHES-MONOMER http://biocyc.org/getid?id=EcoCyc:PHES-MONOMER BioCyc MetaCyc:PHES-MONOMER http://biocyc.org/getid?id=MetaCyc:PHES-MONOMER COG COG0016 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0016 DIP DIP-6878N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-6878N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0014-5793(91)81176-9 http://dx.doi.org/10.1016/0014-5793(91)81176-9 DOI 10.1016/0022-2836(83)90092-X http://dx.doi.org/10.1016/0022-2836(83)90092-X DOI 10.1016/0022-2836(91)90740-W http://dx.doi.org/10.1016/0022-2836(91)90740-W DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.1.1.20 http://www.genome.jp/dbget-bin/www_bget?EC:6.1.1.20 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K02844 http://www.ebi.ac.uk/ena/data/view/K02844 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00291 http://www.ebi.ac.uk/ena/data/view/V00291 ENZYME 6.1.1.20 http://enzyme.expasy.org/EC/6.1.1.20 EchoBASE EB0703 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0703 EcoGene EG10709 http://www.ecogene.org/geneInfo.php?eg_id=EG10709 EnsemblBacteria AAC74784 http://www.ensemblgenomes.org/id/AAC74784 EnsemblBacteria AAC74784 http://www.ensemblgenomes.org/id/AAC74784 EnsemblBacteria BAA15482 http://www.ensemblgenomes.org/id/BAA15482 EnsemblBacteria BAA15482 http://www.ensemblgenomes.org/id/BAA15482 EnsemblBacteria BAA15482 http://www.ensemblgenomes.org/id/BAA15482 EnsemblBacteria b1714 http://www.ensemblgenomes.org/id/b1714 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0009328 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009328 GO_function GO:0000049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000049 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0004826 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004826 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006432 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006432 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GeneID 946223 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946223 HAMAP MF_00281 http://hamap.expasy.org/unirule/MF_00281 HOGENOM HOG000242675 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000242675&db=HOGENOM6 InParanoid P08312 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P08312 IntAct P08312 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P08312* IntEnz 6.1.1.20 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.1.1.20 InterPro IPR002319 http://www.ebi.ac.uk/interpro/entry/IPR002319 InterPro IPR004188 http://www.ebi.ac.uk/interpro/entry/IPR004188 InterPro IPR004529 http://www.ebi.ac.uk/interpro/entry/IPR004529 InterPro IPR006195 http://www.ebi.ac.uk/interpro/entry/IPR006195 InterPro IPR010978 http://www.ebi.ac.uk/interpro/entry/IPR010978 InterPro IPR022911 http://www.ebi.ac.uk/interpro/entry/IPR022911 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW5277 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5277 KEGG_Gene eco:b1714 http://www.genome.jp/dbget-bin/www_bget?eco:b1714 KEGG_Orthology KO:K01889 http://www.genome.jp/dbget-bin/www_bget?KO:K01889 KEGG_Pathway ko00970 http://www.genome.jp/kegg-bin/show_pathway?ko00970 KEGG_Reaction rn:R03660 http://www.genome.jp/dbget-bin/www_bget?rn:R03660 MINT MINT-1229741 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1229741 OMA EYHPARD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EYHPARD PDB 3PCO http://www.ebi.ac.uk/pdbe-srv/view/entry/3PCO PDBsum 3PCO http://www.ebi.ac.uk/pdbsum/3PCO PROSITE PS50862 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50862 PSORT swissprot:SYFA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SYFA_ECOLI PSORT-B swissprot:SYFA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SYFA_ECOLI PSORT2 swissprot:SYFA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SYFA_ECOLI Pfam PF01409 http://pfam.xfam.org/family/PF01409 Pfam PF02912 http://pfam.xfam.org/family/PF02912 Phobius swissprot:SYFA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SYFA_ECOLI PhylomeDB P08312 http://phylomedb.org/?seqid=P08312 ProteinModelPortal P08312 http://www.proteinmodelportal.org/query/uniprot/P08312 PubMed 1537809 http://www.ncbi.nlm.nih.gov/pubmed/1537809 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1942071 http://www.ncbi.nlm.nih.gov/pubmed/1942071 PubMed 1959653 http://www.ncbi.nlm.nih.gov/pubmed/1959653 PubMed 2991205 http://www.ncbi.nlm.nih.gov/pubmed/2991205 PubMed 6317865 http://www.ncbi.nlm.nih.gov/pubmed/6317865 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_416229 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416229 RefSeq WP_000018596 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000018596 SMR P08312 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P08312 STRING 511145.b1714 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1714&targetmode=cogs STRING COG0016 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0016&targetmode=cogs SUPFAM SSF46589 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46589 SWISS-2DPAGE P08312 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P08312 TIGRFAMs TIGR00468 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00468 UniProtKB SYFA_ECOLI http://www.uniprot.org/uniprot/SYFA_ECOLI UniProtKB-AC P08312 http://www.uniprot.org/uniprot/P08312 charge swissprot:SYFA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SYFA_ECOLI eggNOG COG0016 http://eggnogapi.embl.de/nog_data/html/tree/COG0016 eggNOG ENOG4105CSS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CSS epestfind swissprot:SYFA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SYFA_ECOLI garnier swissprot:SYFA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SYFA_ECOLI helixturnhelix swissprot:SYFA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SYFA_ECOLI hmoment swissprot:SYFA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SYFA_ECOLI iep swissprot:SYFA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SYFA_ECOLI inforesidue swissprot:SYFA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SYFA_ECOLI octanol swissprot:SYFA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SYFA_ECOLI pepcoil swissprot:SYFA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SYFA_ECOLI pepdigest swissprot:SYFA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SYFA_ECOLI pepinfo swissprot:SYFA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SYFA_ECOLI pepnet swissprot:SYFA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SYFA_ECOLI pepstats swissprot:SYFA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SYFA_ECOLI pepwheel swissprot:SYFA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SYFA_ECOLI pepwindow swissprot:SYFA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SYFA_ECOLI sigcleave swissprot:SYFA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SYFA_ECOLI ## Database ID URL or Descriptions # AltName MPRA_ECOLI Protein EmrR # BioGrid 4262945 10 # EcoGene EG10603 mprA # FUNCTION MPRA_ECOLI Negative regulator of the multidrug operon emrAB. {ECO 0000269|PubMed 7730261}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IMP:EcoCyc. # GO_process GO:0046677 response to antibiotic; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # INDUCTION MPRA_ECOLI Autoregulated. # IntAct P0ACR9 11 # InterPro IPR000835 HTH_MarR-typ # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR023187 Tscrpt_reg_MarR-type_CS # KEGG_Brite ko03000 Transcription factors # Organism MPRA_ECOLI Escherichia coli (strain K12) # PATRIC 32120760 VBIEscCol129921_2777 # PIR S14473 S14473 # PRINTS PR00598 HTHMARR # PROSITE PS01117 HTH_MARR_1 # PROSITE PS50995 HTH_MARR_2 # Pfam PF01047 MarR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MPRA_ECOLI Transcriptional repressor MprA # RefSeq NP_417169 NC_000913.3 # RefSeq WP_000378442 NZ_LN832404.1 # SIMILARITY Contains 1 HTH marR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00345}. # SMART SM00347 HTH_MARR # SUPFAM SSF46785 SSF46785 # eggNOG COG1846 LUCA # eggNOG ENOG4105NTK Bacteria BLAST swissprot:MPRA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MPRA_ECOLI BioCyc ECOL316407:JW2659-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2659-MONOMER BioCyc EcoCyc:EG10603-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10603-MONOMER COG COG1846 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1846 DIP DIP-10248N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10248N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.89.19.8938 http://dx.doi.org/10.1073/pnas.89.19.8938 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M86657 http://www.ebi.ac.uk/ena/data/view/M86657 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U19993 http://www.ebi.ac.uk/ena/data/view/U19993 EMBL X54151 http://www.ebi.ac.uk/ena/data/view/X54151 EchoBASE EB0598 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0598 EcoGene EG10603 http://www.ecogene.org/geneInfo.php?eg_id=EG10603 EnsemblBacteria AAC75731 http://www.ensemblgenomes.org/id/AAC75731 EnsemblBacteria AAC75731 http://www.ensemblgenomes.org/id/AAC75731 EnsemblBacteria BAA16546 http://www.ensemblgenomes.org/id/BAA16546 EnsemblBacteria BAA16546 http://www.ensemblgenomes.org/id/BAA16546 EnsemblBacteria BAA16546 http://www.ensemblgenomes.org/id/BAA16546 EnsemblBacteria b2684 http://www.ensemblgenomes.org/id/b2684 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 945282 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945282 HOGENOM HOG000117211 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117211&db=HOGENOM6 InParanoid P0ACR9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACR9 IntAct P0ACR9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACR9* InterPro IPR000835 http://www.ebi.ac.uk/interpro/entry/IPR000835 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR023187 http://www.ebi.ac.uk/interpro/entry/IPR023187 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW2659 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2659 KEGG_Gene eco:b2684 http://www.genome.jp/dbget-bin/www_bget?eco:b2684 KEGG_Orthology KO:K15974 http://www.genome.jp/dbget-bin/www_bget?KO:K15974 OMA KMTLTHA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KMTLTHA PRINTS PR00598 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00598 PROSITE PS01117 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01117 PROSITE PS50995 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50995 PSORT swissprot:MPRA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MPRA_ECOLI PSORT-B swissprot:MPRA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MPRA_ECOLI PSORT2 swissprot:MPRA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MPRA_ECOLI Pfam PF01047 http://pfam.xfam.org/family/PF01047 Phobius swissprot:MPRA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MPRA_ECOLI PhylomeDB P0ACR9 http://phylomedb.org/?seqid=P0ACR9 ProteinModelPortal P0ACR9 http://www.proteinmodelportal.org/query/uniprot/P0ACR9 PubMed 1409590 http://www.ncbi.nlm.nih.gov/pubmed/1409590 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1840583 http://www.ncbi.nlm.nih.gov/pubmed/1840583 PubMed 7730261 http://www.ncbi.nlm.nih.gov/pubmed/7730261 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417169 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417169 RefSeq WP_000378442 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000378442 SMART SM00347 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00347 SMR P0ACR9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACR9 STRING 511145.b2684 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2684&targetmode=cogs STRING COG1846 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1846&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB MPRA_ECOLI http://www.uniprot.org/uniprot/MPRA_ECOLI UniProtKB-AC P0ACR9 http://www.uniprot.org/uniprot/P0ACR9 charge swissprot:MPRA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MPRA_ECOLI eggNOG COG1846 http://eggnogapi.embl.de/nog_data/html/tree/COG1846 eggNOG ENOG4105NTK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105NTK epestfind swissprot:MPRA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MPRA_ECOLI garnier swissprot:MPRA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MPRA_ECOLI helixturnhelix swissprot:MPRA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MPRA_ECOLI hmoment swissprot:MPRA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MPRA_ECOLI iep swissprot:MPRA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MPRA_ECOLI inforesidue swissprot:MPRA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MPRA_ECOLI octanol swissprot:MPRA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MPRA_ECOLI pepcoil swissprot:MPRA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MPRA_ECOLI pepdigest swissprot:MPRA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MPRA_ECOLI pepinfo swissprot:MPRA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MPRA_ECOLI pepnet swissprot:MPRA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MPRA_ECOLI pepstats swissprot:MPRA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MPRA_ECOLI pepwheel swissprot:MPRA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MPRA_ECOLI pepwindow swissprot:MPRA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MPRA_ECOLI sigcleave swissprot:MPRA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MPRA_ECOLI ## Database ID URL or Descriptions # EcoGene EG12225 yhiJ # Gene3D 3.60.21.10 -; 1. # IntAct P37627 5 # InterPro IPR025123 DUF4049 # InterPro IPR029052 Metallo-depent_PP-like # Organism YHIJ_ECOLI Escherichia coli (strain K12) # PATRIC 32122422 VBIEscCol129921_3588 # PIR S47708 S47708 # Pfam PF13258 DUF4049 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHIJ_ECOLI Uncharacterized protein YhiJ # RefSeq NP_417945 NC_000913.3 # RefSeq WP_001393583 NZ_LN832404.1 # SUPFAM SSF56300 SSF56300 BLAST swissprot:YHIJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHIJ_ECOLI BioCyc ECOL316407:JW3455-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3455-MONOMER BioCyc EcoCyc:EG12225-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12225-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2138 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2138 EcoGene EG12225 http://www.ecogene.org/geneInfo.php?eg_id=EG12225 EnsemblBacteria AAC76513 http://www.ensemblgenomes.org/id/AAC76513 EnsemblBacteria AAC76513 http://www.ensemblgenomes.org/id/AAC76513 EnsemblBacteria BAE77805 http://www.ensemblgenomes.org/id/BAE77805 EnsemblBacteria BAE77805 http://www.ensemblgenomes.org/id/BAE77805 EnsemblBacteria BAE77805 http://www.ensemblgenomes.org/id/BAE77805 EnsemblBacteria b3488 http://www.ensemblgenomes.org/id/b3488 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.60.21.10 http://www.cathdb.info/version/latest/superfamily/3.60.21.10 GeneID 948001 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948001 HOGENOM HOG000009621 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009621&db=HOGENOM6 IntAct P37627 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37627* InterPro IPR025123 http://www.ebi.ac.uk/interpro/entry/IPR025123 InterPro IPR029052 http://www.ebi.ac.uk/interpro/entry/IPR029052 KEGG_Gene ecj:JW3455 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3455 KEGG_Gene eco:b3488 http://www.genome.jp/dbget-bin/www_bget?eco:b3488 OMA NSYQFIV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NSYQFIV PSORT swissprot:YHIJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHIJ_ECOLI PSORT-B swissprot:YHIJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHIJ_ECOLI PSORT2 swissprot:YHIJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHIJ_ECOLI Pfam PF13258 http://pfam.xfam.org/family/PF13258 Phobius swissprot:YHIJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHIJ_ECOLI ProteinModelPortal P37627 http://www.proteinmodelportal.org/query/uniprot/P37627 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417945 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417945 RefSeq WP_001393583 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001393583 STRING 511145.b3488 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3488&targetmode=cogs SUPFAM SSF56300 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56300 UniProtKB YHIJ_ECOLI http://www.uniprot.org/uniprot/YHIJ_ECOLI UniProtKB-AC P37627 http://www.uniprot.org/uniprot/P37627 charge swissprot:YHIJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHIJ_ECOLI epestfind swissprot:YHIJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHIJ_ECOLI garnier swissprot:YHIJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHIJ_ECOLI helixturnhelix swissprot:YHIJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHIJ_ECOLI hmoment swissprot:YHIJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHIJ_ECOLI iep swissprot:YHIJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHIJ_ECOLI inforesidue swissprot:YHIJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHIJ_ECOLI octanol swissprot:YHIJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHIJ_ECOLI pepcoil swissprot:YHIJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHIJ_ECOLI pepdigest swissprot:YHIJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHIJ_ECOLI pepinfo swissprot:YHIJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHIJ_ECOLI pepnet swissprot:YHIJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHIJ_ECOLI pepstats swissprot:YHIJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHIJ_ECOLI pepwheel swissprot:YHIJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHIJ_ECOLI pepwindow swissprot:YHIJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHIJ_ECOLI sigcleave swissprot:YHIJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHIJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4261565 15 # DISRUPTION PHENOTYPE Essential, it cannot be deleted unless rnlA is also disrupted. {ECO:0000269|PubMed 20980243}. # EcoGene EG13201 rnlB # FUNCTION RNLB_ECOLI Antitoxin component of a toxin-antitoxin (TA) module. A labile antitoxin (half-life of 2.1 minutes) that inhibits the endonuclease activity of cognate toxin RnlA but not that of non- cognate toxin LsoA. {ECO 0000269|PubMed 20980243, ECO 0000269|PubMed 22403819}. # GO_process GO:0060702 negative regulation of endoribonuclease activity; IMP:EcoCyc. # GOslim_process GO:0008150 biological_process # INDUCTION Not repressed by IscR. rnlA-rnlB forms an operon, the downstream rnlB also has its own promoter. {ECO:0000269|PubMed 20421606}. # InterPro IPR031834 RnlB/LsoB_antitoxin # Organism RNLB_ECOLI Escherichia coli (strain K12) # PATRIC 32120653 VBIEscCol129921_2725 # PIR T08643 T08643 # PTM RNLB_ECOLI Probably degraded by CplXP and Lon proteases. # Pfam PF15933 RnlB_antitoxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RNLB_ECOLI Antitoxin RnlB # RefSeq NP_417120 NC_000913.3 # RefSeq WP_000461704 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA79800.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SUBUNIT RNLB_ECOLI Can form a complex with cognate toxin RnlA. # eggNOG ENOG4106BHJ Bacteria # eggNOG ENOG410Y1RN LUCA BLAST swissprot:RNLB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RNLB_ECOLI BioCyc ECOL316407:JW5418-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5418-MONOMER BioCyc EcoCyc:G7366-MONOMER http://biocyc.org/getid?id=EcoCyc:G7366-MONOMER BioCyc MetaCyc:G7366-MONOMER http://biocyc.org/getid?id=MetaCyc:G7366-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2012.07975.x http://dx.doi.org/10.1111/j.1365-2958.2012.07975.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1534/genetics.110.114462 http://dx.doi.org/10.1534/genetics.110.114462 DOI 10.1534/genetics.110.121798 http://dx.doi.org/10.1534/genetics.110.121798 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36840 http://www.ebi.ac.uk/ena/data/view/U36840 EchoBASE EB2993 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2993 EcoGene EG13201 http://www.ecogene.org/geneInfo.php?eg_id=EG13201 EnsemblBacteria AAC75679 http://www.ensemblgenomes.org/id/AAC75679 EnsemblBacteria AAC75679 http://www.ensemblgenomes.org/id/AAC75679 EnsemblBacteria BAE76766 http://www.ensemblgenomes.org/id/BAE76766 EnsemblBacteria BAE76766 http://www.ensemblgenomes.org/id/BAE76766 EnsemblBacteria BAE76766 http://www.ensemblgenomes.org/id/BAE76766 EnsemblBacteria b2631 http://www.ensemblgenomes.org/id/b2631 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0060702 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060702 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 947113 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947113 InterPro IPR031834 http://www.ebi.ac.uk/interpro/entry/IPR031834 KEGG_Gene ecj:JW5418 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5418 KEGG_Gene eco:b2631 http://www.genome.jp/dbget-bin/www_bget?eco:b2631 OMA CSNGFEW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CSNGFEW PSORT swissprot:RNLB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RNLB_ECOLI PSORT-B swissprot:RNLB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RNLB_ECOLI PSORT2 swissprot:RNLB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RNLB_ECOLI Pfam PF15933 http://pfam.xfam.org/family/PF15933 Phobius swissprot:RNLB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RNLB_ECOLI ProteinModelPortal P52130 http://www.proteinmodelportal.org/query/uniprot/P52130 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20421606 http://www.ncbi.nlm.nih.gov/pubmed/20421606 PubMed 20980243 http://www.ncbi.nlm.nih.gov/pubmed/20980243 PubMed 22403819 http://www.ncbi.nlm.nih.gov/pubmed/22403819 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417120 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417120 RefSeq WP_000461704 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000461704 STRING 511145.b2631 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2631&targetmode=cogs UniProtKB RNLB_ECOLI http://www.uniprot.org/uniprot/RNLB_ECOLI UniProtKB-AC P52130 http://www.uniprot.org/uniprot/P52130 charge swissprot:RNLB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RNLB_ECOLI eggNOG ENOG4106BHJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106BHJ eggNOG ENOG410Y1RN http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y1RN epestfind swissprot:RNLB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RNLB_ECOLI garnier swissprot:RNLB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RNLB_ECOLI helixturnhelix swissprot:RNLB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RNLB_ECOLI hmoment swissprot:RNLB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RNLB_ECOLI iep swissprot:RNLB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RNLB_ECOLI inforesidue swissprot:RNLB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RNLB_ECOLI octanol swissprot:RNLB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RNLB_ECOLI pepcoil swissprot:RNLB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RNLB_ECOLI pepdigest swissprot:RNLB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RNLB_ECOLI pepinfo swissprot:RNLB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RNLB_ECOLI pepnet swissprot:RNLB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RNLB_ECOLI pepstats swissprot:RNLB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RNLB_ECOLI pepwheel swissprot:RNLB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RNLB_ECOLI pepwindow swissprot:RNLB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RNLB_ECOLI sigcleave swissprot:RNLB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RNLB_ECOLI ## Database ID URL or Descriptions # BioGrid 4259983 3 # CDD cd06261 TM_PBP2 # EcoGene EG13474 gsiC # FUNCTION GSIC_ECOLI Part of the ABC transporter complex GsiABCD involved in glutathione import. Probably responsible for the translocation of the substrate across the membrane (Probable). {ECO 0000305|PubMed 16109926}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0034634 glutathione transmembrane transporter activity; IDA:EcoCyc. # GO_process GO:0034775 glutathione transmembrane transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0055085 transmembrane transport # Gene3D 1.10.3720.10 -; 1. # InterPro IPR000515 MetI-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00348 Glutathione transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism GSIC_ECOLI Escherichia coli (strain K12) # PATRIC 32116865 VBIEscCol129921_0858 # PIR G64820 G64820 # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GSIC_ECOLI Glutathione transport system permease protein GsiC # RefSeq NP_415352 NC_000913.3 # RefSeq WP_000936043 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION GSIC_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT The complex is composed of two ATP-binding proteins (GsiA), two transmembrane proteins (GsiC and GsiD) and a solute- binding protein (GsiB). {ECO 0000305}. # SUPFAM SSF161098 SSF161098 # TCDB 3.A.1.5.11 the atp-binding cassette (abc) superfamily # eggNOG COG0601 LUCA # eggNOG ENOG4105CJM Bacteria BLAST swissprot:GSIC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GSIC_ECOLI BioCyc ECOL316407:JW0815-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0815-MONOMER BioCyc EcoCyc:YLIC-MONOMER http://biocyc.org/getid?id=EcoCyc:YLIC-MONOMER BioCyc MetaCyc:YLIC-MONOMER http://biocyc.org/getid?id=MetaCyc:YLIC-MONOMER COG COG0601 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0601 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.187.17.5861-5867.2005 http://dx.doi.org/10.1128/JB.187.17.5861-5867.2005 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3247 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3247 EcoGene EG13474 http://www.ecogene.org/geneInfo.php?eg_id=EG13474 EnsemblBacteria AAC73918 http://www.ensemblgenomes.org/id/AAC73918 EnsemblBacteria AAC73918 http://www.ensemblgenomes.org/id/AAC73918 EnsemblBacteria BAA35526 http://www.ensemblgenomes.org/id/BAA35526 EnsemblBacteria BAA35526 http://www.ensemblgenomes.org/id/BAA35526 EnsemblBacteria BAA35526 http://www.ensemblgenomes.org/id/BAA35526 EnsemblBacteria b0831 http://www.ensemblgenomes.org/id/b0831 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0034634 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034634 GO_process GO:0034775 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034775 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 945460 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945460 HOGENOM HOG000170251 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000170251&db=HOGENOM6 InParanoid P75798 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75798 IntAct P75798 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75798* InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0815 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0815 KEGG_Gene eco:b0831 http://www.genome.jp/dbget-bin/www_bget?eco:b0831 KEGG_Orthology KO:K13890 http://www.genome.jp/dbget-bin/www_bget?KO:K13890 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA EVVFQRP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EVVFQRP PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:GSIC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GSIC_ECOLI PSORT-B swissprot:GSIC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GSIC_ECOLI PSORT2 swissprot:GSIC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GSIC_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Phobius swissprot:GSIC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GSIC_ECOLI PhylomeDB P75798 http://phylomedb.org/?seqid=P75798 ProteinModelPortal P75798 http://www.proteinmodelportal.org/query/uniprot/P75798 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16109926 http://www.ncbi.nlm.nih.gov/pubmed/16109926 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415352 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415352 RefSeq WP_000936043 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000936043 SMR P75798 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75798 STRING 511145.b0831 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0831&targetmode=cogs STRING COG0601 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0601&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.5.11 http://www.tcdb.org/search/result.php?tc=3.A.1.5.11 UniProtKB GSIC_ECOLI http://www.uniprot.org/uniprot/GSIC_ECOLI UniProtKB-AC P75798 http://www.uniprot.org/uniprot/P75798 charge swissprot:GSIC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GSIC_ECOLI eggNOG COG0601 http://eggnogapi.embl.de/nog_data/html/tree/COG0601 eggNOG ENOG4105CJM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CJM epestfind swissprot:GSIC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GSIC_ECOLI garnier swissprot:GSIC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GSIC_ECOLI helixturnhelix swissprot:GSIC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GSIC_ECOLI hmoment swissprot:GSIC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GSIC_ECOLI iep swissprot:GSIC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GSIC_ECOLI inforesidue swissprot:GSIC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GSIC_ECOLI octanol swissprot:GSIC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GSIC_ECOLI pepcoil swissprot:GSIC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GSIC_ECOLI pepdigest swissprot:GSIC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GSIC_ECOLI pepinfo swissprot:GSIC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GSIC_ECOLI pepnet swissprot:GSIC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GSIC_ECOLI pepstats swissprot:GSIC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GSIC_ECOLI pepwheel swissprot:GSIC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GSIC_ECOLI pepwindow swissprot:GSIC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GSIC_ECOLI sigcleave swissprot:GSIC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GSIC_ECOLI ## Database ID URL or Descriptions # BioGrid 4261008 46 # EcoGene EG13627 ybcK # GO_function GO:0000150 recombinase activity; IEA:InterPro. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # Gene3D 3.40.50.1390 -; 1. # IntAct P77698 2 # InterPro IPR006119 Resolv_N # InterPro IPR011109 DNA_bind_recombinase_dom # InterPro IPR025827 Zn_ribbon_recom_dom # MISCELLANEOUS YBCK_ECOLI Encoded by the cryptic lambdoid prophage DLP12. # Organism YBCK_ECOLI Escherichia coli (strain K12) # PATRIC 32116252 VBIEscCol129921_0566 # PIR F64786 F64786 # PROSITE PS51736 RECOMBINASES_3 # PROSITE PS51737 RECOMBINASE_DNA_BIND # Pfam PF00239 Resolvase # Pfam PF07508 Recombinase # Pfam PF13408 Zn_ribbon_recom # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBCK_ECOLI Uncharacterized protein YbcK # RefSeq NP_415076 NC_000913.3 # RefSeq WP_000709082 NZ_LN832404.1 # SIMILARITY Contains 1 recombinase DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU01073}. # SIMILARITY Contains 1 resolvase/invertase-type recombinase catalytic domain. {ECO:0000255|PROSITE-ProRule PRU01072}. # SMART SM00857 Resolvase # SUPFAM SSF53041 SSF53041 # eggNOG COG1961 LUCA # eggNOG ENOG4107TII Bacteria BLAST swissprot:YBCK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBCK_ECOLI BioCyc ECOL316407:JW0532-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0532-MONOMER BioCyc EcoCyc:G6300-MONOMER http://biocyc.org/getid?id=EcoCyc:G6300-MONOMER DIP DIP-11332N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11332N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB3392 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3392 EcoGene EG13627 http://www.ecogene.org/geneInfo.php?eg_id=EG13627 EnsemblBacteria AAC73645 http://www.ensemblgenomes.org/id/AAC73645 EnsemblBacteria AAC73645 http://www.ensemblgenomes.org/id/AAC73645 EnsemblBacteria BAE76319 http://www.ensemblgenomes.org/id/BAE76319 EnsemblBacteria BAE76319 http://www.ensemblgenomes.org/id/BAE76319 EnsemblBacteria BAE76319 http://www.ensemblgenomes.org/id/BAE76319 EnsemblBacteria b0544 http://www.ensemblgenomes.org/id/b0544 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000150 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 Gene3D 3.40.50.1390 http://www.cathdb.info/version/latest/superfamily/3.40.50.1390 GeneID 945166 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945166 HOGENOM HOG000054896 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000054896&db=HOGENOM6 IntAct P77698 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77698* InterPro IPR006119 http://www.ebi.ac.uk/interpro/entry/IPR006119 InterPro IPR011109 http://www.ebi.ac.uk/interpro/entry/IPR011109 InterPro IPR025827 http://www.ebi.ac.uk/interpro/entry/IPR025827 KEGG_Gene ecj:JW0532 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0532 KEGG_Gene eco:b0544 http://www.genome.jp/dbget-bin/www_bget?eco:b0544 OMA DRPAIPN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DRPAIPN PROSITE PS51736 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51736 PROSITE PS51737 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51737 PSORT swissprot:YBCK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBCK_ECOLI PSORT-B swissprot:YBCK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBCK_ECOLI PSORT2 swissprot:YBCK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBCK_ECOLI Pfam PF00239 http://pfam.xfam.org/family/PF00239 Pfam PF07508 http://pfam.xfam.org/family/PF07508 Pfam PF13408 http://pfam.xfam.org/family/PF13408 Phobius swissprot:YBCK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBCK_ECOLI ProteinModelPortal P77698 http://www.proteinmodelportal.org/query/uniprot/P77698 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415076 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415076 RefSeq WP_000709082 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000709082 SMART SM00857 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00857 SMR P77698 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77698 STRING 511145.b0544 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0544&targetmode=cogs SUPFAM SSF53041 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53041 UniProtKB YBCK_ECOLI http://www.uniprot.org/uniprot/YBCK_ECOLI UniProtKB-AC P77698 http://www.uniprot.org/uniprot/P77698 charge swissprot:YBCK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBCK_ECOLI eggNOG COG1961 http://eggnogapi.embl.de/nog_data/html/tree/COG1961 eggNOG ENOG4107TII http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107TII epestfind swissprot:YBCK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBCK_ECOLI garnier swissprot:YBCK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBCK_ECOLI helixturnhelix swissprot:YBCK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBCK_ECOLI hmoment swissprot:YBCK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBCK_ECOLI iep swissprot:YBCK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBCK_ECOLI inforesidue swissprot:YBCK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBCK_ECOLI octanol swissprot:YBCK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBCK_ECOLI pepcoil swissprot:YBCK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBCK_ECOLI pepdigest swissprot:YBCK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBCK_ECOLI pepinfo swissprot:YBCK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBCK_ECOLI pepnet swissprot:YBCK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBCK_ECOLI pepstats swissprot:YBCK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBCK_ECOLI pepwheel swissprot:YBCK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBCK_ECOLI pepwindow swissprot:YBCK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBCK_ECOLI sigcleave swissprot:YBCK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBCK_ECOLI ## Database ID URL or Descriptions # AltName PUR9_ECOLI AICAR transformylase # AltName PUR9_ECOLI AICAR transformylase # AltName PUR9_ECOLI ATIC # AltName PUR9_ECOLI IMP synthase # AltName PUR9_ECOLI Inosinicase # BioGrid 4262461 24 # CATALYTIC ACTIVITY PUR9_ECOLI 10-formyltetrahydrofolate + 5-amino-1-(5- phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5- formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. # CATALYTIC ACTIVITY PUR9_ECOLI IMP + H(2)O = 5-formamido-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide. # DOMAIN PUR9_ECOLI The IMP cyclohydrolase activity resides in the N-terminal region. {ECO 0000250}. # EcoGene EG10795 purH # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003937 IMP cyclohydrolase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0004643 phosphoribosylaminoimidazolecarboxamide formyltransferase activity; IEA:UniProtKB-HAMAP. # GO_process GO:0006189 'de novo' IMP biosynthetic process; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.140.20 -; 2. # Gene3D 3.40.50.1380 -; 1. # HAMAP MF_00139 PurH # IntAct P15639 7 # InterPro IPR002695 AICARFT_IMPCHas # InterPro IPR011607 MGS-like_dom # InterPro IPR016193 Cytidine_deaminase-like # InterPro IPR024051 AICAR_Tfase_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00670 One carbon pool by folate # Organism PUR9_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11692 PTHR11692 # PATHWAY Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5- amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route) step 1/1. # PATHWAY Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4- carboxamide step 1/1. # PATRIC 32123537 VBIEscCol129921_4121 # PIR B34193 DTECPH # PIRSF PIRSF000414 AICARFT_IMPCHas # Pfam PF01808 AICARFT_IMPCHas # Pfam PF02142 MGS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PUR9_ECOLI Bifunctional purine biosynthesis protein PurH # RecName PUR9_ECOLI Bifunctional purine biosynthesis protein PurH # RecName PUR9_ECOLI IMP cyclohydrolase # RecName PUR9_ECOLI Phosphoribosylaminoimidazolecarboxamide formyltransferase # RefSeq NP_418434 NC_000913.3 # RefSeq WP_001187559 NZ_LN832404.1 # SIMILARITY Belongs to the PurH family. {ECO 0000305}. # SMART SM00798 AICARFT_IMPCHas # SMART SM00851 MGS # SUPFAM SSF52335 SSF52335 # SUPFAM SSF53927 SSF53927 # TIGRFAMs TIGR00355 purH # UniPathway UPA00074 UER00133 # UniPathway UPA00074 UER00135 # eggNOG COG0138 LUCA # eggNOG ENOG4105DC1 Bacteria BLAST swissprot:PUR9_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PUR9_ECOLI BioCyc ECOL316407:JW3970-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3970-MONOMER BioCyc EcoCyc:AICARTRANSIMPCYCLO-CPLX http://biocyc.org/getid?id=EcoCyc:AICARTRANSIMPCYCLO-CPLX BioCyc MetaCyc:AICARTRANSIMPCYCLO-CPLX http://biocyc.org/getid?id=MetaCyc:AICARTRANSIMPCYCLO-CPLX COG COG0138 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0138 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1111/j.1365-2958.1990.tb00605.x http://dx.doi.org/10.1111/j.1365-2958.1990.tb00605.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.2.3 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.2.3 EC_number EC:3.5.4.10 http://www.genome.jp/dbget-bin/www_bget?EC:3.5.4.10 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J05126 http://www.ebi.ac.uk/ena/data/view/J05126 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X51950 http://www.ebi.ac.uk/ena/data/view/X51950 ENZYME 2.1.2.3 http://enzyme.expasy.org/EC/2.1.2.3 ENZYME 3.5.4.10 http://enzyme.expasy.org/EC/3.5.4.10 EchoBASE EB0788 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0788 EcoGene EG10795 http://www.ecogene.org/geneInfo.php?eg_id=EG10795 EnsemblBacteria AAC76980 http://www.ensemblgenomes.org/id/AAC76980 EnsemblBacteria AAC76980 http://www.ensemblgenomes.org/id/AAC76980 EnsemblBacteria BAE77313 http://www.ensemblgenomes.org/id/BAE77313 EnsemblBacteria BAE77313 http://www.ensemblgenomes.org/id/BAE77313 EnsemblBacteria BAE77313 http://www.ensemblgenomes.org/id/BAE77313 EnsemblBacteria b4006 http://www.ensemblgenomes.org/id/b4006 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003937 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003937 GO_function GO:0004643 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004643 GO_process GO:0006189 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006189 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.140.20 http://www.cathdb.info/version/latest/superfamily/3.40.140.20 Gene3D 3.40.50.1380 http://www.cathdb.info/version/latest/superfamily/3.40.50.1380 GeneID 948503 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948503 HAMAP MF_00139 http://hamap.expasy.org/unirule/MF_00139 HOGENOM HOG000230372 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230372&db=HOGENOM6 InParanoid P15639 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P15639 IntAct P15639 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P15639* IntEnz 2.1.2.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.2.3 IntEnz 3.5.4.10 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.4.10 InterPro IPR002695 http://www.ebi.ac.uk/interpro/entry/IPR002695 InterPro IPR011607 http://www.ebi.ac.uk/interpro/entry/IPR011607 InterPro IPR016193 http://www.ebi.ac.uk/interpro/entry/IPR016193 InterPro IPR024051 http://www.ebi.ac.uk/interpro/entry/IPR024051 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3970 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3970 KEGG_Gene eco:b4006 http://www.genome.jp/dbget-bin/www_bget?eco:b4006 KEGG_Orthology KO:K00602 http://www.genome.jp/dbget-bin/www_bget?KO:K00602 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00670 http://www.genome.jp/kegg-bin/show_pathway?ko00670 KEGG_Reaction rn:R01127 http://www.genome.jp/dbget-bin/www_bget?rn:R01127 KEGG_Reaction rn:R04560 http://www.genome.jp/dbget-bin/www_bget?rn:R04560 OMA PCGVAEG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PCGVAEG PANTHER PTHR11692 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11692 PSORT swissprot:PUR9_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PUR9_ECOLI PSORT-B swissprot:PUR9_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PUR9_ECOLI PSORT2 swissprot:PUR9_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PUR9_ECOLI Pfam PF01808 http://pfam.xfam.org/family/PF01808 Pfam PF02142 http://pfam.xfam.org/family/PF02142 Phobius swissprot:PUR9_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PUR9_ECOLI PhylomeDB P15639 http://phylomedb.org/?seqid=P15639 ProteinModelPortal P15639 http://www.proteinmodelportal.org/query/uniprot/P15639 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 2192230 http://www.ncbi.nlm.nih.gov/pubmed/2192230 PubMed 2687276 http://www.ncbi.nlm.nih.gov/pubmed/2687276 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_418434 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418434 RefSeq WP_001187559 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001187559 SMART SM00798 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00798 SMART SM00851 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00851 SMR P15639 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P15639 STRING 511145.b4006 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4006&targetmode=cogs STRING COG0138 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0138&targetmode=cogs SUPFAM SSF52335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52335 SUPFAM SSF53927 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53927 SWISS-2DPAGE P15639 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P15639 TIGRFAMs TIGR00355 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00355 UniProtKB PUR9_ECOLI http://www.uniprot.org/uniprot/PUR9_ECOLI UniProtKB-AC P15639 http://www.uniprot.org/uniprot/P15639 charge swissprot:PUR9_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PUR9_ECOLI eggNOG COG0138 http://eggnogapi.embl.de/nog_data/html/tree/COG0138 eggNOG ENOG4105DC1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DC1 epestfind swissprot:PUR9_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PUR9_ECOLI garnier swissprot:PUR9_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PUR9_ECOLI helixturnhelix swissprot:PUR9_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PUR9_ECOLI hmoment swissprot:PUR9_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PUR9_ECOLI iep swissprot:PUR9_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PUR9_ECOLI inforesidue swissprot:PUR9_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PUR9_ECOLI octanol swissprot:PUR9_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PUR9_ECOLI pepcoil swissprot:PUR9_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PUR9_ECOLI pepdigest swissprot:PUR9_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PUR9_ECOLI pepinfo swissprot:PUR9_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PUR9_ECOLI pepnet swissprot:PUR9_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PUR9_ECOLI pepstats swissprot:PUR9_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PUR9_ECOLI pepwheel swissprot:PUR9_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PUR9_ECOLI pepwindow swissprot:PUR9_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PUR9_ECOLI sigcleave swissprot:PUR9_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PUR9_ECOLI ## Database ID URL or Descriptions # BioGrid 4261705 8 # EcoGene EG13077 yqfA # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0019835 cytolysis; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0008150 biological_process # InterPro IPR004254 AdipoR/HlyIII-related # InterPro IPR005744 Hy-lIII # KEGG_Brite ko02042 Bacterial toxins # Organism YQFA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR20855 PTHR20855 # PANTHER PTHR20855:SF3 PTHR20855:SF3 # PATRIC 32121212 VBIEscCol129921_2994 # PIR C65074 C65074 # Pfam PF03006 HlyIII # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQFA_ECOLI UPF0073 inner membrane protein YqfA # RefSeq NP_417375 NC_000913.3 # RefSeq WP_000250274 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0073 (Hly-III) family. {ECO 0000305}. # SUBCELLULAR LOCATION YQFA_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 1.C.113.1.10 1.c.113 the hly iii (hly iii) family # TIGRFAMs TIGR01065 hlyIII # eggNOG COG1272 LUCA # eggNOG ENOG4108UT2 Bacteria BLAST swissprot:YQFA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQFA_ECOLI BioCyc ECOL316407:JW2867-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2867-MONOMER BioCyc EcoCyc:G7512-MONOMER http://biocyc.org/getid?id=EcoCyc:G7512-MONOMER COG COG1272 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1272 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 EchoBASE EB2887 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2887 EcoGene EG13077 http://www.ecogene.org/geneInfo.php?eg_id=EG13077 EnsemblBacteria AAC75937 http://www.ensemblgenomes.org/id/AAC75937 EnsemblBacteria AAC75937 http://www.ensemblgenomes.org/id/AAC75937 EnsemblBacteria BAE76964 http://www.ensemblgenomes.org/id/BAE76964 EnsemblBacteria BAE76964 http://www.ensemblgenomes.org/id/BAE76964 EnsemblBacteria BAE76964 http://www.ensemblgenomes.org/id/BAE76964 EnsemblBacteria b2899 http://www.ensemblgenomes.org/id/b2899 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0019835 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019835 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 947381 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947381 HOGENOM HOG000039438 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000039438&db=HOGENOM6 InParanoid P67153 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P67153 InterPro IPR004254 http://www.ebi.ac.uk/interpro/entry/IPR004254 InterPro IPR005744 http://www.ebi.ac.uk/interpro/entry/IPR005744 KEGG_Brite ko02042 http://www.genome.jp/dbget-bin/www_bget?ko02042 KEGG_Gene ecj:JW2867 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2867 KEGG_Gene eco:b2899 http://www.genome.jp/dbget-bin/www_bget?eco:b2899 KEGG_Orthology KO:K11068 http://www.genome.jp/dbget-bin/www_bget?KO:K11068 OMA ASHFWLM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ASHFWLM PANTHER PTHR20855 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20855 PANTHER PTHR20855:SF3 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20855:SF3 PSORT swissprot:YQFA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQFA_ECOLI PSORT-B swissprot:YQFA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQFA_ECOLI PSORT2 swissprot:YQFA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQFA_ECOLI Pfam PF03006 http://pfam.xfam.org/family/PF03006 Phobius swissprot:YQFA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQFA_ECOLI PhylomeDB P67153 http://phylomedb.org/?seqid=P67153 ProteinModelPortal P67153 http://www.proteinmodelportal.org/query/uniprot/P67153 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417375 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417375 RefSeq WP_000250274 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000250274 STRING 511145.b2899 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2899&targetmode=cogs STRING COG1272 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1272&targetmode=cogs TCDB 1.C.113.1.10 http://www.tcdb.org/search/result.php?tc=1.C.113.1.10 TIGRFAMs TIGR01065 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01065 UniProtKB YQFA_ECOLI http://www.uniprot.org/uniprot/YQFA_ECOLI UniProtKB-AC P67153 http://www.uniprot.org/uniprot/P67153 charge swissprot:YQFA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQFA_ECOLI eggNOG COG1272 http://eggnogapi.embl.de/nog_data/html/tree/COG1272 eggNOG ENOG4108UT2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UT2 epestfind swissprot:YQFA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQFA_ECOLI garnier swissprot:YQFA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQFA_ECOLI helixturnhelix swissprot:YQFA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQFA_ECOLI hmoment swissprot:YQFA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQFA_ECOLI iep swissprot:YQFA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQFA_ECOLI inforesidue swissprot:YQFA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQFA_ECOLI octanol swissprot:YQFA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQFA_ECOLI pepcoil swissprot:YQFA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQFA_ECOLI pepdigest swissprot:YQFA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQFA_ECOLI pepinfo swissprot:YQFA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQFA_ECOLI pepnet swissprot:YQFA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQFA_ECOLI pepstats swissprot:YQFA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQFA_ECOLI pepwheel swissprot:YQFA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQFA_ECOLI pepwindow swissprot:YQFA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQFA_ECOLI sigcleave swissprot:YQFA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQFA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261527 145 # EcoGene EG13412 csgF # FUNCTION CSGF_ECOLI May be involved in the biogenesis of curli organelles. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_process GO:0022610 biological adhesion; IMP:EcoCyc. # GO_process GO:0044010 single-species biofilm formation; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0008150 biological_process # InterPro IPR018893 T8SS_CsgF # KEGG_Brite ko02044 Secretion system # Organism CSGF_ECOLI Escherichia coli (strain K12) # PATRIC 32117309 VBIEscCol129921_1077 # PIR S70784 S70784 # Pfam PF10614 CsgF # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CSGF_ECOLI Curli production assembly/transport component CsgF # RefSeq NP_415556 NC_000913.3 # RefSeq WP_001264088 NZ_LN832404.1 # TCDB 1.B.48.1 the curli fiber subunit, csga, porin, csgg (csgg) family # eggNOG ENOG4108WYR Bacteria # eggNOG ENOG4111JSD LUCA BLAST swissprot:CSGF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CSGF_ECOLI BioCyc ECOL316407:JW1021-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1021-MONOMER BioCyc EcoCyc:G6544-MONOMER http://biocyc.org/getid?id=EcoCyc:G6544-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1995.mmi_18040661.x http://dx.doi.org/10.1111/j.1365-2958.1995.mmi_18040661.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AF081826 http://www.ebi.ac.uk/ena/data/view/AF081826 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X90754 http://www.ebi.ac.uk/ena/data/view/X90754 EchoBASE EB3188 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3188 EcoGene EG13412 http://www.ecogene.org/geneInfo.php?eg_id=EG13412 EnsemblBacteria AAC74122 http://www.ensemblgenomes.org/id/AAC74122 EnsemblBacteria AAC74122 http://www.ensemblgenomes.org/id/AAC74122 EnsemblBacteria BAA35819 http://www.ensemblgenomes.org/id/BAA35819 EnsemblBacteria BAA35819 http://www.ensemblgenomes.org/id/BAA35819 EnsemblBacteria BAA35819 http://www.ensemblgenomes.org/id/BAA35819 EnsemblBacteria b1038 http://www.ensemblgenomes.org/id/b1038 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_process GO:0022610 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022610 GO_process GO:0044010 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044010 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 945622 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945622 HOGENOM HOG000295951 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000295951&db=HOGENOM6 InterPro IPR018893 http://www.ebi.ac.uk/interpro/entry/IPR018893 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW1021 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1021 KEGG_Gene eco:b1038 http://www.genome.jp/dbget-bin/www_bget?eco:b1038 KEGG_Orthology KO:K04338 http://www.genome.jp/dbget-bin/www_bget?KO:K04338 OMA PVNPNFG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PVNPNFG PSORT swissprot:CSGF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CSGF_ECOLI PSORT-B swissprot:CSGF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CSGF_ECOLI PSORT2 swissprot:CSGF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CSGF_ECOLI Pfam PF10614 http://pfam.xfam.org/family/PF10614 Phobius swissprot:CSGF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CSGF_ECOLI ProteinModelPortal P0AE98 http://www.proteinmodelportal.org/query/uniprot/P0AE98 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8817489 http://www.ncbi.nlm.nih.gov/pubmed/8817489 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415556 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415556 RefSeq WP_001264088 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001264088 STRING 511145.b1038 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1038&targetmode=cogs TCDB 1.B.48.1 http://www.tcdb.org/search/result.php?tc=1.B.48.1 UniProtKB CSGF_ECOLI http://www.uniprot.org/uniprot/CSGF_ECOLI UniProtKB-AC P0AE98 http://www.uniprot.org/uniprot/P0AE98 charge swissprot:CSGF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CSGF_ECOLI eggNOG ENOG4108WYR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108WYR eggNOG ENOG4111JSD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111JSD epestfind swissprot:CSGF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CSGF_ECOLI garnier swissprot:CSGF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CSGF_ECOLI helixturnhelix swissprot:CSGF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CSGF_ECOLI hmoment swissprot:CSGF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CSGF_ECOLI iep swissprot:CSGF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CSGF_ECOLI inforesidue swissprot:CSGF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CSGF_ECOLI octanol swissprot:CSGF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CSGF_ECOLI pepcoil swissprot:CSGF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CSGF_ECOLI pepdigest swissprot:CSGF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CSGF_ECOLI pepinfo swissprot:CSGF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CSGF_ECOLI pepnet swissprot:CSGF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CSGF_ECOLI pepstats swissprot:CSGF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CSGF_ECOLI pepwheel swissprot:CSGF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CSGF_ECOLI pepwindow swissprot:CSGF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CSGF_ECOLI sigcleave swissprot:CSGF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CSGF_ECOLI ## Database ID URL or Descriptions # BioGrid 4261278 189 # EcoGene EG12474 blc # FUNCTION BLC_ECOLI Involved in the storage or transport of lipids necessary for membrane maintenance under stressful conditions. Displays a binding preference for lysophospholipids. {ECO 0000269|PubMed 15044022}. # GO_component GO:0009279 cell outer membrane; IEA:UniProtKB-SubCell. # GO_function GO:0005215 transporter activity; IEA:InterPro. # GO_function GO:0008289 lipid binding; IEA:UniProtKB-KW. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008289 lipid binding # GOslim_process GO:0006950 response to stress # Gene3D 2.40.128.20 -; 1. # INDUCTION BLC_ECOLI By starvation and high osmolarity. # IntAct P0A901 6 # InterPro IPR000566 Lipocln_cytosolic_FA-bd_dom # InterPro IPR002446 Lipocalin_bac # InterPro IPR011038 Calycin-like # InterPro IPR012674 Calycin # InterPro IPR022271 Lipocalin_ApoD # InterPro IPR022272 Lipocalin_CS # Organism BLC_ECOLI Escherichia coli (strain K12) # PATRIC 32123871 VBIEscCol129921_4283 # PDB 1QWD X-ray; 1.75 A; A/B=23-177 # PDB 2ACO X-ray; 1.80 A; A/B=23-177 # PDB 3MBT X-ray; 2.60 A; A=19-177 # PIR I84534 I84534 # PIRSF PIRSF036893 Lipocalin_ApoD # PRINTS PR01171 BCTLIPOCALIN # PROSITE PS00213 LIPOCALIN # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF08212 Lipocalin_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BLC_ECOLI Outer membrane lipoprotein Blc # RefSeq NP_418573 NC_000913.3 # RefSeq WP_001238378 NZ_LN832404.1 # SIMILARITY Belongs to the calycin superfamily. Lipocalin family. {ECO 0000305}. # SUBCELLULAR LOCATION BLC_ECOLI Cell outer membrane; Lipid-anchor. # SUBUNIT Homodimer. {ECO:0000269|PubMed 16920109}. # SUPFAM SSF50814 SSF50814 # eggNOG COG3040 LUCA # eggNOG ENOG4105QNF Bacteria BLAST swissprot:BLC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BLC_ECOLI BioCyc ECOL316407:JW4110-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4110-MONOMER BioCyc EcoCyc:G7837-MONOMER http://biocyc.org/getid?id=EcoCyc:G7837-MONOMER COG COG3040 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3040 DIP DIP-35862N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35862N DOI 10.1016/S0014-5793(04)00199-1 http://dx.doi.org/10.1016/S0014-5793(04)00199-1 DOI 10.1016/j.febslet.2006.07.086 http://dx.doi.org/10.1016/j.febslet.2006.07.086 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.270.39.23097 http://dx.doi.org/10.1074/jbc.270.39.23097 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL U21726 http://www.ebi.ac.uk/ena/data/view/U21726 EchoBASE EB2367 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2367 EcoGene EG12474 http://www.ecogene.org/geneInfo.php?eg_id=EG12474 EnsemblBacteria AAC77109 http://www.ensemblgenomes.org/id/AAC77109 EnsemblBacteria AAC77109 http://www.ensemblgenomes.org/id/AAC77109 EnsemblBacteria BAE78153 http://www.ensemblgenomes.org/id/BAE78153 EnsemblBacteria BAE78153 http://www.ensemblgenomes.org/id/BAE78153 EnsemblBacteria BAE78153 http://www.ensemblgenomes.org/id/BAE78153 EnsemblBacteria b4149 http://www.ensemblgenomes.org/id/b4149 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_function GO:0008289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 2.40.128.20 http://www.cathdb.info/version/latest/superfamily/2.40.128.20 GeneID 948670 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948670 HOGENOM HOG000061524 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000061524&db=HOGENOM6 InParanoid P0A901 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A901 IntAct P0A901 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A901* InterPro IPR000566 http://www.ebi.ac.uk/interpro/entry/IPR000566 InterPro IPR002446 http://www.ebi.ac.uk/interpro/entry/IPR002446 InterPro IPR011038 http://www.ebi.ac.uk/interpro/entry/IPR011038 InterPro IPR012674 http://www.ebi.ac.uk/interpro/entry/IPR012674 InterPro IPR022271 http://www.ebi.ac.uk/interpro/entry/IPR022271 InterPro IPR022272 http://www.ebi.ac.uk/interpro/entry/IPR022272 KEGG_Gene ecj:JW4110 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4110 KEGG_Gene eco:b4149 http://www.genome.jp/dbget-bin/www_bget?eco:b4149 KEGG_Orthology KO:K03098 http://www.genome.jp/dbget-bin/www_bget?KO:K03098 OMA VINRGFN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VINRGFN PDB 1QWD http://www.ebi.ac.uk/pdbe-srv/view/entry/1QWD PDB 2ACO http://www.ebi.ac.uk/pdbe-srv/view/entry/2ACO PDB 3MBT http://www.ebi.ac.uk/pdbe-srv/view/entry/3MBT PDBsum 1QWD http://www.ebi.ac.uk/pdbsum/1QWD PDBsum 2ACO http://www.ebi.ac.uk/pdbsum/2ACO PDBsum 3MBT http://www.ebi.ac.uk/pdbsum/3MBT PRINTS PR01171 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01171 PROSITE PS00213 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00213 PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:BLC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BLC_ECOLI PSORT-B swissprot:BLC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BLC_ECOLI PSORT2 swissprot:BLC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BLC_ECOLI Pfam PF08212 http://pfam.xfam.org/family/PF08212 Phobius swissprot:BLC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BLC_ECOLI PhylomeDB P0A901 http://phylomedb.org/?seqid=P0A901 ProteinModelPortal P0A901 http://www.proteinmodelportal.org/query/uniprot/P0A901 PubMed 15044022 http://www.ncbi.nlm.nih.gov/pubmed/15044022 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16920109 http://www.ncbi.nlm.nih.gov/pubmed/16920109 PubMed 7559452 http://www.ncbi.nlm.nih.gov/pubmed/7559452 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418573 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418573 RefSeq WP_001238378 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001238378 SMR P0A901 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A901 STRING 511145.b4149 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4149&targetmode=cogs STRING COG3040 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3040&targetmode=cogs SUPFAM SSF50814 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50814 UniProtKB BLC_ECOLI http://www.uniprot.org/uniprot/BLC_ECOLI UniProtKB-AC P0A901 http://www.uniprot.org/uniprot/P0A901 charge swissprot:BLC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BLC_ECOLI eggNOG COG3040 http://eggnogapi.embl.de/nog_data/html/tree/COG3040 eggNOG ENOG4105QNF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105QNF epestfind swissprot:BLC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BLC_ECOLI garnier swissprot:BLC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BLC_ECOLI helixturnhelix swissprot:BLC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BLC_ECOLI hmoment swissprot:BLC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BLC_ECOLI iep swissprot:BLC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BLC_ECOLI inforesidue swissprot:BLC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BLC_ECOLI octanol swissprot:BLC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BLC_ECOLI pepcoil swissprot:BLC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BLC_ECOLI pepdigest swissprot:BLC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BLC_ECOLI pepinfo swissprot:BLC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BLC_ECOLI pepnet swissprot:BLC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BLC_ECOLI pepstats swissprot:BLC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BLC_ECOLI pepwheel swissprot:BLC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BLC_ECOLI pepwindow swissprot:BLC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BLC_ECOLI sigcleave swissprot:BLC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BLC_ECOLI ## Database ID URL or Descriptions # BioGrid 4261241 11 # EcoGene EG11695 yidG # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR003807 DUF202 # InterPro IPR020264 Uncharacterised_YidG # Organism YIDG_ECOLI Escherichia coli (strain K12) # PATRIC 32122841 VBIEscCol129921_3796 # PIR D65169 D65169 # Pfam PF02656 DUF202 # ProDom PD277113 Inner_membrane_protein_yidG # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIDG_ECOLI Inner membrane protein YidG # RefSeq NP_418131 NC_000913.3 # RefSeq WP_001113432 NZ_LN832404.1 # SUBCELLULAR LOCATION YIDG_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG ENOG4105JP4 Bacteria # eggNOG ENOG4111NSM LUCA BLAST swissprot:YIDG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIDG_ECOLI BioCyc ECOL316407:JW3651-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3651-MONOMER BioCyc EcoCyc:EG11695-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11695-MONOMER DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1646 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1646 EcoGene EG11695 http://www.ecogene.org/geneInfo.php?eg_id=EG11695 EnsemblBacteria AAC76698 http://www.ensemblgenomes.org/id/AAC76698 EnsemblBacteria AAC76698 http://www.ensemblgenomes.org/id/AAC76698 EnsemblBacteria BAE77618 http://www.ensemblgenomes.org/id/BAE77618 EnsemblBacteria BAE77618 http://www.ensemblgenomes.org/id/BAE77618 EnsemblBacteria BAE77618 http://www.ensemblgenomes.org/id/BAE77618 EnsemblBacteria b3675 http://www.ensemblgenomes.org/id/b3675 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 948191 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948191 HOGENOM HOG000126304 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126304&db=HOGENOM6 InterPro IPR003807 http://www.ebi.ac.uk/interpro/entry/IPR003807 InterPro IPR020264 http://www.ebi.ac.uk/interpro/entry/IPR020264 KEGG_Gene ecj:JW3651 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3651 KEGG_Gene eco:b3675 http://www.genome.jp/dbget-bin/www_bget?eco:b3675 OMA WRYTRSR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WRYTRSR PSORT swissprot:YIDG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIDG_ECOLI PSORT-B swissprot:YIDG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIDG_ECOLI PSORT2 swissprot:YIDG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIDG_ECOLI Pfam PF02656 http://pfam.xfam.org/family/PF02656 Phobius swissprot:YIDG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIDG_ECOLI ProteinModelPortal P0ADL6 http://www.proteinmodelportal.org/query/uniprot/P0ADL6 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418131 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418131 RefSeq WP_001113432 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001113432 STRING 511145.b3675 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3675&targetmode=cogs UniProtKB YIDG_ECOLI http://www.uniprot.org/uniprot/YIDG_ECOLI UniProtKB-AC P0ADL6 http://www.uniprot.org/uniprot/P0ADL6 charge swissprot:YIDG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIDG_ECOLI eggNOG ENOG4105JP4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105JP4 eggNOG ENOG4111NSM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111NSM epestfind swissprot:YIDG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIDG_ECOLI garnier swissprot:YIDG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIDG_ECOLI helixturnhelix swissprot:YIDG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIDG_ECOLI hmoment swissprot:YIDG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIDG_ECOLI iep swissprot:YIDG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIDG_ECOLI inforesidue swissprot:YIDG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIDG_ECOLI octanol swissprot:YIDG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIDG_ECOLI pepcoil swissprot:YIDG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIDG_ECOLI pepdigest swissprot:YIDG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIDG_ECOLI pepinfo swissprot:YIDG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIDG_ECOLI pepnet swissprot:YIDG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIDG_ECOLI pepstats swissprot:YIDG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIDG_ECOLI pepwheel swissprot:YIDG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIDG_ECOLI pepwindow swissprot:YIDG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIDG_ECOLI sigcleave swissprot:YIDG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIDG_ECOLI ## Database ID URL or Descriptions # AltName LIVG_ECOLI LIV-I protein G # BioGrid 4261119 377 # EcoGene EG10537 livG # FUNCTION LIVG_ECOLI Component of the leucine-specific transport system. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0015658 branched-chain amino acid transmembrane transporter activity; IMP:EcoCyc. # GO_function GO:0016887 ATPase activity; IEA:InterPro. # GO_process GO:0015803 branched-chain amino acid transport; IMP:EcoCyc. # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # Gene3D 3.40.50.300 -; 1. # IntAct P0A9S7 6 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # InterPro IPR032823 BCA_ABC_TP_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00237 Branched-chain amino acid transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism LIVG_ECOLI Escherichia coli (strain K12) # PATRIC 32122352 VBIEscCol129921_3553 # PIR F37074 F37074 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # Pfam PF00005 ABC_tran # Pfam PF12399 BCA_ABC_TP_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LIVG_ECOLI High-affinity branched-chain amino acid transport ATP-binding protein LivG # RefSeq NP_417912 NC_000913.3 # RefSeq WP_000082101 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA # SUPFAM SSF52540 SSF52540 # TCDB 3.A.1.4 the atp-binding cassette (abc) superfamily # eggNOG COG0411 LUCA # eggNOG ENOG4105C0Z Bacteria BLAST swissprot:LIVG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LIVG_ECOLI BioCyc ECOL316407:JW3420-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3420-MONOMER BioCyc EcoCyc:LIVG-MONOMER http://biocyc.org/getid?id=EcoCyc:LIVG-MONOMER BioCyc MetaCyc:LIVG-MONOMER http://biocyc.org/getid?id=MetaCyc:LIVG-MONOMER COG COG0411 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0411 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J05516 http://www.ebi.ac.uk/ena/data/view/J05516 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0532 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0532 EcoGene EG10537 http://www.ecogene.org/geneInfo.php?eg_id=EG10537 EnsemblBacteria AAC76480 http://www.ensemblgenomes.org/id/AAC76480 EnsemblBacteria AAC76480 http://www.ensemblgenomes.org/id/AAC76480 EnsemblBacteria BAE77838 http://www.ensemblgenomes.org/id/BAE77838 EnsemblBacteria BAE77838 http://www.ensemblgenomes.org/id/BAE77838 EnsemblBacteria BAE77838 http://www.ensemblgenomes.org/id/BAE77838 EnsemblBacteria b3455 http://www.ensemblgenomes.org/id/b3455 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0015658 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015658 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_process GO:0015803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015803 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947967 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947967 InParanoid P0A9S7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9S7 IntAct P0A9S7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9S7* InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR032823 http://www.ebi.ac.uk/interpro/entry/IPR032823 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3420 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3420 KEGG_Gene eco:b3455 http://www.genome.jp/dbget-bin/www_bget?eco:b3455 KEGG_Orthology KO:K01995 http://www.genome.jp/dbget-bin/www_bget?KO:K01995 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA AMERAQY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AMERAQY PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:LIVG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LIVG_ECOLI PSORT-B swissprot:LIVG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LIVG_ECOLI PSORT2 swissprot:LIVG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LIVG_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Pfam PF12399 http://pfam.xfam.org/family/PF12399 Phobius swissprot:LIVG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LIVG_ECOLI PhylomeDB P0A9S7 http://phylomedb.org/?seqid=P0A9S7 ProteinModelPortal P0A9S7 http://www.proteinmodelportal.org/query/uniprot/P0A9S7 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2195019 http://www.ncbi.nlm.nih.gov/pubmed/2195019 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417912 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417912 RefSeq WP_000082101 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000082101 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P0A9S7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9S7 STRING 511145.b3455 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3455&targetmode=cogs STRING COG0411 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0411&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.4 http://www.tcdb.org/search/result.php?tc=3.A.1.4 UniProtKB LIVG_ECOLI http://www.uniprot.org/uniprot/LIVG_ECOLI UniProtKB-AC P0A9S7 http://www.uniprot.org/uniprot/P0A9S7 charge swissprot:LIVG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LIVG_ECOLI eggNOG COG0411 http://eggnogapi.embl.de/nog_data/html/tree/COG0411 eggNOG ENOG4105C0Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C0Z epestfind swissprot:LIVG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LIVG_ECOLI garnier swissprot:LIVG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LIVG_ECOLI helixturnhelix swissprot:LIVG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LIVG_ECOLI hmoment swissprot:LIVG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LIVG_ECOLI iep swissprot:LIVG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LIVG_ECOLI inforesidue swissprot:LIVG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LIVG_ECOLI octanol swissprot:LIVG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LIVG_ECOLI pepcoil swissprot:LIVG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LIVG_ECOLI pepdigest swissprot:LIVG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LIVG_ECOLI pepinfo swissprot:LIVG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LIVG_ECOLI pepnet swissprot:LIVG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LIVG_ECOLI pepstats swissprot:LIVG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LIVG_ECOLI pepwheel swissprot:LIVG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LIVG_ECOLI pepwindow swissprot:LIVG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LIVG_ECOLI sigcleave swissprot:LIVG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LIVG_ECOLI ## Database ID URL or Descriptions # AltName BGAL_ECOLI Lactase # BIOPHYSICOCHEMICAL PROPERTIES BGAL_ECOLI Kinetic parameters KM=0.04 mM for p-nitrophenyl beta-D-galactoside {ECO 0000269|PubMed 114210, ECO 0000269|PubMed 12578395, ECO 0000269|PubMed 14621996, ECO 0000269|PubMed 15060622, ECO 0000269|PubMed 8662937, ECO 0000269|PubMed 9665715}; KM=0.12 mM for o-nitrophenyl beta-D-galactoside {ECO 0000269|PubMed 114210, ECO 0000269|PubMed 12578395, ECO 0000269|PubMed 14621996, ECO 0000269|PubMed 15060622, ECO 0000269|PubMed 8662937, ECO 0000269|PubMed 9665715}; KM=0.15 mM for 2,3-dinitrophenyl beta-D-galactopyranoside {ECO 0000269|PubMed 114210, ECO 0000269|PubMed 12578395, ECO 0000269|PubMed 14621996, ECO 0000269|PubMed 15060622, ECO 0000269|PubMed 8662937, ECO 0000269|PubMed 9665715}; KM=0.41 mM for 2,5-dinitrophenyl beta-D-galactopyranoside {ECO 0000269|PubMed 114210, ECO 0000269|PubMed 12578395, ECO 0000269|PubMed 14621996, ECO 0000269|PubMed 15060622, ECO 0000269|PubMed 8662937, ECO 0000269|PubMed 9665715}; KM=11.6 mM for p-nitrophenol-alpha-L-arabinopyranoside {ECO 0000269|PubMed 114210, ECO 0000269|PubMed 12578395, ECO 0000269|PubMed 14621996, ECO 0000269|PubMed 15060622, ECO 0000269|PubMed 8662937, ECO 0000269|PubMed 9665715}; KM=16.9 mM for p-nitrophenol-beta-D-fucopyranoside {ECO 0000269|PubMed 114210, ECO 0000269|PubMed 12578395, ECO 0000269|PubMed 14621996, ECO 0000269|PubMed 15060622, ECO 0000269|PubMed 8662937, ECO 0000269|PubMed 9665715}; KM=34 uM for p-nitrophenyl beta-D-galactoside (with magnesium as cofactor and 30 degrees Celsius) {ECO 0000269|PubMed 114210, ECO 0000269|PubMed 12578395, ECO 0000269|PubMed 14621996, ECO 0000269|PubMed 15060622, ECO 0000269|PubMed 8662937, ECO 0000269|PubMed 9665715}; KM=140 uM for o-nitrophenyl beta-D-galactoside (with magnesium as cofactor and 30 degrees Celsius) {ECO 0000269|PubMed 114210, ECO 0000269|PubMed 12578395, ECO 0000269|PubMed 14621996, ECO 0000269|PubMed 15060622, ECO 0000269|PubMed 8662937, ECO 0000269|PubMed 9665715}; KM=940 uM for allolactose (with magnesium as cofactor and 30 degrees Celsius) {ECO 0000269|PubMed 114210, ECO 0000269|PubMed 12578395, ECO 0000269|PubMed 14621996, ECO 0000269|PubMed 15060622, ECO 0000269|PubMed 8662937, ECO 0000269|PubMed 9665715}; KM=1350 uM for lactose (with magnesium as cofactor and 30 degrees Celsius) {ECO 0000269|PubMed 114210, ECO 0000269|PubMed 12578395, ECO 0000269|PubMed 14621996, ECO 0000269|PubMed 15060622, ECO 0000269|PubMed 8662937, ECO 0000269|PubMed 9665715}; Vmax=30.9 umol/min/mg enzyme with lactose as substrate (with magnesium as cofactor and 30 degrees Celsius) {ECO 0000269|PubMed 114210, ECO 0000269|PubMed 12578395, ECO 0000269|PubMed 14621996, ECO 0000269|PubMed 15060622, ECO 0000269|PubMed 8662937, ECO 0000269|PubMed 9665715}; Vmax=49.7 umol/min/mg enzyme with allolactose as substrate (with magnesium as cofactor and 30 degrees Celsius) {ECO 0000269|PubMed 114210, ECO 0000269|PubMed 12578395, ECO 0000269|PubMed 14621996, ECO 0000269|PubMed 15060622, ECO 0000269|PubMed 8662937, ECO 0000269|PubMed 9665715}; Vmax=59.7 umol/min/mg enzyme with p-nitrophenyl beta-D- galactoside as substrate (with magnesium as cofactor and 30 degrees Celsius) {ECO 0000269|PubMed 114210, ECO 0000269|PubMed 12578395, ECO 0000269|PubMed 14621996, ECO 0000269|PubMed 15060622, ECO 0000269|PubMed 8662937, ECO 0000269|PubMed 9665715}; Vmax=360 umol/min/mg enzyme with o-nitrophenyl beta-D- galactoside as substrate (with magnesium as cofactor and 30 degrees Celsius) {ECO 0000269|PubMed 114210, ECO 0000269|PubMed 12578395, ECO 0000269|PubMed 14621996, ECO 0000269|PubMed 15060622, ECO 0000269|PubMed 8662937, ECO 0000269|PubMed 9665715}; Note=The values for the enzymatic assays using manganese as cofactor are very close.; # BRENDA 3.2.1.23 2026 # CATALYTIC ACTIVITY BGAL_ECOLI Hydrolysis of terminal non-reducing beta-D- galactose residues in beta-D-galactosides. # CAZy GH2 Glycoside Hydrolase Family 2 # COFACTOR BGAL_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Note=Binds 2 magnesium ions per monomer. Can also use manganese.; # COFACTOR Name=Na(+); Xref=ChEBI:CHEBI 29101; Note=Binds 1 sodium ion per monomer.; # DrugBank DB04465 Lactose # ENZYME REGULATION Inhibited by phenylethyl thio-beta-D- galactoside (PETG), isopropyl thio-beta-D-galactoside (IPTG), L- ribose, D-galactonolactone, lactose and 2-amino-D-galactose. {ECO:0000269|PubMed 14621996}. # EcoGene EG10527 lacZ # GO_component GO:0009341 beta-galactosidase complex; IDA:EcoCyc. # GO_component GO:0043231 intracellular membrane-bounded organelle; IBA:GO_Central. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0004565 beta-galactosidase activity; IDA:EcoCyc. # GO_function GO:0030246 carbohydrate binding; IEA:InterPro. # GO_function GO:0031420 alkali metal ion binding; IDA:EcoCyc. # GO_process GO:0005990 lactose catabolic process; IMP:CACAO. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043226 organelle # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # Gene3D 2.60.120.260 -; 1. # Gene3D 2.60.40.320 -; 2. # Gene3D 2.70.98.10 -; 1. # Gene3D 3.20.20.80 -; 1. # HAMAP MF_01687 Beta_gal # INDUCTION By allolactose. {ECO:0000269|PubMed 4562709}. # IntAct P00722 76 # InterPro IPR004199 B-gal_small/dom_5 # InterPro IPR006101 Glyco_hydro_2 # InterPro IPR006102 Glyco_hydro_2_Ig-like # InterPro IPR006103 Glyco_hydro_2_cat # InterPro IPR006104 Glyco_hydro_2_N # InterPro IPR008979 Galactose-bd-like # InterPro IPR011013 Gal_mutarotase_SF_dom # InterPro IPR013781 Glyco_hydro_catalytic_dom # InterPro IPR013812 Glyco_hydro_2/20_Ig-like # InterPro IPR014718 GH-type_carb-bd # InterPro IPR017853 Glycoside_hydrolase_SF # InterPro IPR023230 Glyco_hydro_2_CS # InterPro IPR023232 Glyco_hydro_2_AS # InterPro IPR023933 Glyco_hydro_2_beta_Galsidase # InterPro IPR032312 LacZ_4 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00052 Galactose metabolism # KEGG_Pathway ko00511 Other glycan degradation # KEGG_Pathway ko00600 Sphingolipid metabolism # Organism BGAL_ECOLI Escherichia coli (strain K12) # PATRIC 32115821 VBIEscCol129921_0352 # PDB 1DP0 X-ray; 1.70 A; A/B/C/D=10-1024 # PDB 1F4A X-ray; 2.80 A; A/B/C/D=4-1024 # PDB 1F4H X-ray; 2.80 A; A/B/C/D=4-1024 # PDB 1HN1 X-ray; 3.00 A; A/B/C/D=10-1024 # PDB 1JYN X-ray; 1.80 A; A/B/C/D=10-1024 # PDB 1JYV X-ray; 1.75 A; A/B/C/D=10-1024 # PDB 1JYW X-ray; 1.55 A; A/B/C/D=10-1024 # PDB 1JYX X-ray; 1.75 A; A/B/C/D=10-1024 # PDB 1JZ2 X-ray; 2.10 A; A/B/C/D=2-1024 # PDB 1JZ3 X-ray; 1.75 A; A/B/C/D=10-1024 # PDB 1JZ4 X-ray; 2.10 A; A/B/C/D=10-1024 # PDB 1JZ5 X-ray; 1.80 A; A/B/C/D=10-1024 # PDB 1JZ6 X-ray; 2.10 A; A/B/C/D=10-1024 # PDB 1JZ7 X-ray; 1.50 A; A/B/C/D=10-1024 # PDB 1JZ8 X-ray; 1.50 A; A/B/C/D=10-1024 # PDB 1PX3 X-ray; 1.60 A; A/B/C/D=10-1024 # PDB 1PX4 X-ray; 1.60 A; A/B/C/D=10-1024 # PDB 3CZJ X-ray; 2.05 A; A/B/C/D=10-1024 # PDB 3DYM X-ray; 2.05 A; A/B/C/D=10-1024 # PDB 3DYO X-ray; 1.80 A; A/B/C/D=10-1024 # PDB 3DYP X-ray; 1.75 A; A/B/C/D=10-1024 # PDB 3E1F X-ray; 3.00 A; 1/2/3/4=10-1024 # PDB 3I3B X-ray; 2.20 A; A/B/C/D=10-1024 # PDB 3I3D X-ray; 2.20 A; A/B/C/D=10-1024 # PDB 3I3E X-ray; 2.10 A; A/B/C/D=10-1024 # PDB 3IAP X-ray; 2.00 A; A/B/C/D=10-1024 # PDB 3IAQ X-ray; 2.70 A; A/B/C/D=10-1024 # PDB 3J7H EM; 3.20 A; A/B/C/D=1-1024 # PDB 3MUY X-ray; 2.50 A; 1/2/3/4=10-1024 # PDB 3MUZ X-ray; 1.90 A; 1/2/3/4=10-1024 # PDB 3MV0 X-ray; 2.20 A; 1/2/3/4=10-1024 # PDB 3MV1 X-ray; 2.20 A; 1/2/3/4=10-1024 # PDB 3SEP X-ray; 2.05 A; A/B/C/D=10-1024 # PDB 3T08 X-ray; 2.00 A; A/B/C/D=10-1024 # PDB 3T09 X-ray; 1.75 A; A/B/C/D=10-1024 # PDB 3T0A X-ray; 1.90 A; A/B/C/D=10-1024 # PDB 3T0B X-ray; 2.40 A; A/B/C/D=10-1024 # PDB 3T0D X-ray; 1.93 A; A/B/C/D=10-1024 # PDB 3T2O X-ray; 1.85 A; A/B/C/D=10-1024 # PDB 3T2P X-ray; 2.60 A; A/B/C/D=10-1024 # PDB 3T2Q X-ray; 2.40 A; A/B/C/D=10-1024 # PDB 3VD3 X-ray; 2.80 A; A/B/C/D=10-1024 # PDB 3VD4 X-ray; 2.00 A; A/B/C/D=10-1024 # PDB 3VD5 X-ray; 2.70 A; A/B/C/D=10-1024 # PDB 3VD7 X-ray; 2.87 A; A/B/C/D=10-1024 # PDB 3VD9 X-ray; 2.05 A; A/B/C/D=10-1024 # PDB 3VDA X-ray; 2.50 A; A/B/C/D=10-1024 # PDB 3VDB X-ray; 2.05 A; A/B/C/D=10-1024 # PDB 3VDC X-ray; 2.55 A; A/B/C/D=10-1024 # PDB 4CKD EM; 13.00 A; A/B/C/D=1-1024 # PDB 4DUV X-ray; 2.10 A; A/B/C/D=10-1024 # PDB 4DUW X-ray; 2.20 A; A/B/C/D=10-1024 # PDB 4DUX X-ray; 2.30 A; A/B/C/D=10-1024 # PDB 4TTG X-ray; 1.60 A; A/B/C/D=15-1024 # PDB 4V40 X-ray; 2.50 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P=2-1024 # PDB 4V41 X-ray; 2.50 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P=2-1024 # PDB 4V44 X-ray; 2.70 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P=2-1024 # PDB 4V45 X-ray; 2.60 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P=2-1024 # PDB 5A1A EM; 2.20 A; A/B/C/D=3-1024 # PIR A90981 GBEC # PRINTS PR00132 GLHYDRLASE2 # PROSITE PS00608 GLYCOSYL_HYDROL_F2_2 # PROSITE PS00719 GLYCOSYL_HYDROL_F2_1 # Pfam PF00703 Glyco_hydro_2 # Pfam PF02836 Glyco_hydro_2_C # Pfam PF02837 Glyco_hydro_2_N # Pfam PF02929 Bgal_small_N # Pfam PF16353 DUF4981 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BGAL_ECOLI Beta-galactosidase # RefSeq NP_414878 NC_000913.3 # RefSeq WP_000177906 NZ_LN832404.1 # SIMILARITY Belongs to the glycosyl hydrolase 2 family. {ECO 0000305}. # SMART SM01038 Bgal_small_N # SUBUNIT BGAL_ECOLI Homotetramer. {ECO 0000269|PubMed 11045615, ECO 0000269|PubMed 11732897, ECO 0000269|PubMed 14621996, ECO 0000269|PubMed 8008071}. # SUPFAM SSF49303 SSF49303; 2 # SUPFAM SSF49785 SSF49785 # SUPFAM SSF51445 SSF51445 # SUPFAM SSF74650 SSF74650 # WEB RESOURCE BGAL_ECOLI Name=Worthington enzyme manual; URL="http //www.worthington-biochem.com/BG/"; # eggNOG COG3250 LUCA # eggNOG ENOG4105CNT Bacteria BLAST swissprot:BGAL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BGAL_ECOLI BioCyc ECOL316407:JW0335-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0335-MONOMER BioCyc EcoCyc:BETAGALACTOSID-MONOMER http://biocyc.org/getid?id=EcoCyc:BETAGALACTOSID-MONOMER BioCyc MetaCyc:BETAGALACTOSID-MONOMER http://biocyc.org/getid?id=MetaCyc:BETAGALACTOSID-MONOMER COG COG3250 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3250 DIP DIP-10081N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10081N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0022-2836(72)90253-7 http://dx.doi.org/10.1016/0022-2836(72)90253-7 DOI 10.1016/j.bbrc.2006.11.061 http://dx.doi.org/10.1016/j.bbrc.2006.11.061 DOI 10.1016/j.crvi.2005.03.006 http://dx.doi.org/10.1016/j.crvi.2005.03.006 DOI 10.1021/bi00041a022 http://dx.doi.org/10.1021/bi00041a022 DOI 10.1021/bi00586a005 http://dx.doi.org/10.1021/bi00586a005 DOI 10.1021/bi011727i http://dx.doi.org/10.1021/bi011727i DOI 10.1021/bi0270642 http://dx.doi.org/10.1021/bi0270642 DOI 10.1021/bi035506j http://dx.doi.org/10.1021/bi035506j DOI 10.1021/bi972796t http://dx.doi.org/10.1021/bi972796t DOI 10.1038/283541a0 http://dx.doi.org/10.1038/283541a0 DOI 10.1038/285038a0 http://dx.doi.org/10.1038/285038a0 DOI 10.1038/369761a0 http://dx.doi.org/10.1038/369761a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.271.24.14296 http://dx.doi.org/10.1074/jbc.271.24.14296 DOI 10.1110/ps.9.9.1685 http://dx.doi.org/10.1110/ps.9.9.1685 DOI 10.1111/j.1432-1033.1984.tb07947.x http://dx.doi.org/10.1111/j.1432-1033.1984.tb07947.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1139/o00-101 http://dx.doi.org/10.1139/o00-101 DOI 10.1139/o04-004 http://dx.doi.org/10.1139/o04-004 DrugBank DB04465 http://www.drugbank.ca/drugs/DB04465 EC_number EC:3.2.1.23 http://www.genome.jp/dbget-bin/www_bget?EC:3.2.1.23 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01636 http://www.ebi.ac.uk/ena/data/view/J01636 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EMBL V00295 http://www.ebi.ac.uk/ena/data/view/V00295 EMBL V00296 http://www.ebi.ac.uk/ena/data/view/V00296 ENZYME 3.2.1.23 http://enzyme.expasy.org/EC/3.2.1.23 EchoBASE EB0522 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0522 EcoGene EG10527 http://www.ecogene.org/geneInfo.php?eg_id=EG10527 EnsemblBacteria AAC73447 http://www.ensemblgenomes.org/id/AAC73447 EnsemblBacteria AAC73447 http://www.ensemblgenomes.org/id/AAC73447 EnsemblBacteria BAE76126 http://www.ensemblgenomes.org/id/BAE76126 EnsemblBacteria BAE76126 http://www.ensemblgenomes.org/id/BAE76126 EnsemblBacteria BAE76126 http://www.ensemblgenomes.org/id/BAE76126 EnsemblBacteria b0344 http://www.ensemblgenomes.org/id/b0344 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009341 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009341 GO_component GO:0043231 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0004565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004565 GO_function GO:0030246 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030246 GO_function GO:0031420 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031420 GO_process GO:0005990 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005990 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 2.60.120.260 http://www.cathdb.info/version/latest/superfamily/2.60.120.260 Gene3D 2.60.40.320 http://www.cathdb.info/version/latest/superfamily/2.60.40.320 Gene3D 2.70.98.10 http://www.cathdb.info/version/latest/superfamily/2.70.98.10 Gene3D 3.20.20.80 http://www.cathdb.info/version/latest/superfamily/3.20.20.80 GeneID 945006 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945006 HAMAP MF_01687 http://hamap.expasy.org/unirule/MF_01687 HOGENOM HOG000252443 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000252443&db=HOGENOM6 InParanoid P00722 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00722 IntAct P00722 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00722* IntEnz 3.2.1.23 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.2.1.23 InterPro IPR004199 http://www.ebi.ac.uk/interpro/entry/IPR004199 InterPro IPR006101 http://www.ebi.ac.uk/interpro/entry/IPR006101 InterPro IPR006102 http://www.ebi.ac.uk/interpro/entry/IPR006102 InterPro IPR006103 http://www.ebi.ac.uk/interpro/entry/IPR006103 InterPro IPR006104 http://www.ebi.ac.uk/interpro/entry/IPR006104 InterPro IPR008979 http://www.ebi.ac.uk/interpro/entry/IPR008979 InterPro IPR011013 http://www.ebi.ac.uk/interpro/entry/IPR011013 InterPro IPR013781 http://www.ebi.ac.uk/interpro/entry/IPR013781 InterPro IPR013812 http://www.ebi.ac.uk/interpro/entry/IPR013812 InterPro IPR014718 http://www.ebi.ac.uk/interpro/entry/IPR014718 InterPro IPR017853 http://www.ebi.ac.uk/interpro/entry/IPR017853 InterPro IPR023230 http://www.ebi.ac.uk/interpro/entry/IPR023230 InterPro IPR023232 http://www.ebi.ac.uk/interpro/entry/IPR023232 InterPro IPR023933 http://www.ebi.ac.uk/interpro/entry/IPR023933 InterPro IPR032312 http://www.ebi.ac.uk/interpro/entry/IPR032312 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0335 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0335 KEGG_Gene eco:b0344 http://www.genome.jp/dbget-bin/www_bget?eco:b0344 KEGG_Orthology KO:K01190 http://www.genome.jp/dbget-bin/www_bget?KO:K01190 KEGG_Pathway ko00052 http://www.genome.jp/kegg-bin/show_pathway?ko00052 KEGG_Pathway ko00511 http://www.genome.jp/kegg-bin/show_pathway?ko00511 KEGG_Pathway ko00600 http://www.genome.jp/kegg-bin/show_pathway?ko00600 KEGG_Reaction rn:R01105 http://www.genome.jp/dbget-bin/www_bget?rn:R01105 KEGG_Reaction rn:R01678 http://www.genome.jp/dbget-bin/www_bget?rn:R01678 KEGG_Reaction rn:R03355 http://www.genome.jp/dbget-bin/www_bget?rn:R03355 KEGG_Reaction rn:R04783 http://www.genome.jp/dbget-bin/www_bget?rn:R04783 KEGG_Reaction rn:R06114 http://www.genome.jp/dbget-bin/www_bget?rn:R06114 OMA CLDGLLF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CLDGLLF PDB 1DP0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1DP0 PDB 1F4A http://www.ebi.ac.uk/pdbe-srv/view/entry/1F4A PDB 1F4H http://www.ebi.ac.uk/pdbe-srv/view/entry/1F4H PDB 1HN1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1HN1 PDB 1JYN http://www.ebi.ac.uk/pdbe-srv/view/entry/1JYN PDB 1JYV http://www.ebi.ac.uk/pdbe-srv/view/entry/1JYV PDB 1JYW http://www.ebi.ac.uk/pdbe-srv/view/entry/1JYW PDB 1JYX http://www.ebi.ac.uk/pdbe-srv/view/entry/1JYX PDB 1JZ2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1JZ2 PDB 1JZ3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1JZ3 PDB 1JZ4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1JZ4 PDB 1JZ5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1JZ5 PDB 1JZ6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1JZ6 PDB 1JZ7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1JZ7 PDB 1JZ8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1JZ8 PDB 1PX3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1PX3 PDB 1PX4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1PX4 PDB 3CZJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3CZJ PDB 3DYM http://www.ebi.ac.uk/pdbe-srv/view/entry/3DYM PDB 3DYO http://www.ebi.ac.uk/pdbe-srv/view/entry/3DYO PDB 3DYP http://www.ebi.ac.uk/pdbe-srv/view/entry/3DYP PDB 3E1F http://www.ebi.ac.uk/pdbe-srv/view/entry/3E1F PDB 3I3B http://www.ebi.ac.uk/pdbe-srv/view/entry/3I3B PDB 3I3D http://www.ebi.ac.uk/pdbe-srv/view/entry/3I3D PDB 3I3E http://www.ebi.ac.uk/pdbe-srv/view/entry/3I3E PDB 3IAP http://www.ebi.ac.uk/pdbe-srv/view/entry/3IAP PDB 3IAQ http://www.ebi.ac.uk/pdbe-srv/view/entry/3IAQ PDB 3J7H http://www.ebi.ac.uk/pdbe-srv/view/entry/3J7H PDB 3MUY http://www.ebi.ac.uk/pdbe-srv/view/entry/3MUY PDB 3MUZ http://www.ebi.ac.uk/pdbe-srv/view/entry/3MUZ PDB 3MV0 http://www.ebi.ac.uk/pdbe-srv/view/entry/3MV0 PDB 3MV1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3MV1 PDB 3SEP http://www.ebi.ac.uk/pdbe-srv/view/entry/3SEP PDB 3T08 http://www.ebi.ac.uk/pdbe-srv/view/entry/3T08 PDB 3T09 http://www.ebi.ac.uk/pdbe-srv/view/entry/3T09 PDB 3T0A http://www.ebi.ac.uk/pdbe-srv/view/entry/3T0A PDB 3T0B http://www.ebi.ac.uk/pdbe-srv/view/entry/3T0B PDB 3T0D http://www.ebi.ac.uk/pdbe-srv/view/entry/3T0D PDB 3T2O http://www.ebi.ac.uk/pdbe-srv/view/entry/3T2O PDB 3T2P http://www.ebi.ac.uk/pdbe-srv/view/entry/3T2P PDB 3T2Q http://www.ebi.ac.uk/pdbe-srv/view/entry/3T2Q PDB 3VD3 http://www.ebi.ac.uk/pdbe-srv/view/entry/3VD3 PDB 3VD4 http://www.ebi.ac.uk/pdbe-srv/view/entry/3VD4 PDB 3VD5 http://www.ebi.ac.uk/pdbe-srv/view/entry/3VD5 PDB 3VD7 http://www.ebi.ac.uk/pdbe-srv/view/entry/3VD7 PDB 3VD9 http://www.ebi.ac.uk/pdbe-srv/view/entry/3VD9 PDB 3VDA http://www.ebi.ac.uk/pdbe-srv/view/entry/3VDA PDB 3VDB http://www.ebi.ac.uk/pdbe-srv/view/entry/3VDB PDB 3VDC http://www.ebi.ac.uk/pdbe-srv/view/entry/3VDC PDB 4CKD http://www.ebi.ac.uk/pdbe-srv/view/entry/4CKD PDB 4DUV http://www.ebi.ac.uk/pdbe-srv/view/entry/4DUV PDB 4DUW http://www.ebi.ac.uk/pdbe-srv/view/entry/4DUW PDB 4DUX http://www.ebi.ac.uk/pdbe-srv/view/entry/4DUX PDB 4TTG http://www.ebi.ac.uk/pdbe-srv/view/entry/4TTG PDB 4V40 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V40 PDB 4V41 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V41 PDB 4V44 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V44 PDB 4V45 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V45 PDB 5A1A http://www.ebi.ac.uk/pdbe-srv/view/entry/5A1A PDBsum 1DP0 http://www.ebi.ac.uk/pdbsum/1DP0 PDBsum 1F4A http://www.ebi.ac.uk/pdbsum/1F4A PDBsum 1F4H http://www.ebi.ac.uk/pdbsum/1F4H PDBsum 1HN1 http://www.ebi.ac.uk/pdbsum/1HN1 PDBsum 1JYN http://www.ebi.ac.uk/pdbsum/1JYN PDBsum 1JYV http://www.ebi.ac.uk/pdbsum/1JYV PDBsum 1JYW http://www.ebi.ac.uk/pdbsum/1JYW PDBsum 1JYX http://www.ebi.ac.uk/pdbsum/1JYX PDBsum 1JZ2 http://www.ebi.ac.uk/pdbsum/1JZ2 PDBsum 1JZ3 http://www.ebi.ac.uk/pdbsum/1JZ3 PDBsum 1JZ4 http://www.ebi.ac.uk/pdbsum/1JZ4 PDBsum 1JZ5 http://www.ebi.ac.uk/pdbsum/1JZ5 PDBsum 1JZ6 http://www.ebi.ac.uk/pdbsum/1JZ6 PDBsum 1JZ7 http://www.ebi.ac.uk/pdbsum/1JZ7 PDBsum 1JZ8 http://www.ebi.ac.uk/pdbsum/1JZ8 PDBsum 1PX3 http://www.ebi.ac.uk/pdbsum/1PX3 PDBsum 1PX4 http://www.ebi.ac.uk/pdbsum/1PX4 PDBsum 3CZJ http://www.ebi.ac.uk/pdbsum/3CZJ PDBsum 3DYM http://www.ebi.ac.uk/pdbsum/3DYM PDBsum 3DYO http://www.ebi.ac.uk/pdbsum/3DYO PDBsum 3DYP http://www.ebi.ac.uk/pdbsum/3DYP PDBsum 3E1F http://www.ebi.ac.uk/pdbsum/3E1F PDBsum 3I3B http://www.ebi.ac.uk/pdbsum/3I3B PDBsum 3I3D http://www.ebi.ac.uk/pdbsum/3I3D PDBsum 3I3E http://www.ebi.ac.uk/pdbsum/3I3E PDBsum 3IAP http://www.ebi.ac.uk/pdbsum/3IAP PDBsum 3IAQ http://www.ebi.ac.uk/pdbsum/3IAQ PDBsum 3J7H http://www.ebi.ac.uk/pdbsum/3J7H PDBsum 3MUY http://www.ebi.ac.uk/pdbsum/3MUY PDBsum 3MUZ http://www.ebi.ac.uk/pdbsum/3MUZ PDBsum 3MV0 http://www.ebi.ac.uk/pdbsum/3MV0 PDBsum 3MV1 http://www.ebi.ac.uk/pdbsum/3MV1 PDBsum 3SEP http://www.ebi.ac.uk/pdbsum/3SEP PDBsum 3T08 http://www.ebi.ac.uk/pdbsum/3T08 PDBsum 3T09 http://www.ebi.ac.uk/pdbsum/3T09 PDBsum 3T0A http://www.ebi.ac.uk/pdbsum/3T0A PDBsum 3T0B http://www.ebi.ac.uk/pdbsum/3T0B PDBsum 3T0D http://www.ebi.ac.uk/pdbsum/3T0D PDBsum 3T2O http://www.ebi.ac.uk/pdbsum/3T2O PDBsum 3T2P http://www.ebi.ac.uk/pdbsum/3T2P PDBsum 3T2Q http://www.ebi.ac.uk/pdbsum/3T2Q PDBsum 3VD3 http://www.ebi.ac.uk/pdbsum/3VD3 PDBsum 3VD4 http://www.ebi.ac.uk/pdbsum/3VD4 PDBsum 3VD5 http://www.ebi.ac.uk/pdbsum/3VD5 PDBsum 3VD7 http://www.ebi.ac.uk/pdbsum/3VD7 PDBsum 3VD9 http://www.ebi.ac.uk/pdbsum/3VD9 PDBsum 3VDA http://www.ebi.ac.uk/pdbsum/3VDA PDBsum 3VDB http://www.ebi.ac.uk/pdbsum/3VDB PDBsum 3VDC http://www.ebi.ac.uk/pdbsum/3VDC PDBsum 4CKD http://www.ebi.ac.uk/pdbsum/4CKD PDBsum 4DUV http://www.ebi.ac.uk/pdbsum/4DUV PDBsum 4DUW http://www.ebi.ac.uk/pdbsum/4DUW PDBsum 4DUX http://www.ebi.ac.uk/pdbsum/4DUX PDBsum 4TTG http://www.ebi.ac.uk/pdbsum/4TTG PDBsum 4V40 http://www.ebi.ac.uk/pdbsum/4V40 PDBsum 4V41 http://www.ebi.ac.uk/pdbsum/4V41 PDBsum 4V44 http://www.ebi.ac.uk/pdbsum/4V44 PDBsum 4V45 http://www.ebi.ac.uk/pdbsum/4V45 PDBsum 5A1A http://www.ebi.ac.uk/pdbsum/5A1A PRINTS PR00132 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00132 PROSITE PS00608 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00608 PROSITE PS00719 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00719 PSORT swissprot:BGAL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BGAL_ECOLI PSORT-B swissprot:BGAL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BGAL_ECOLI PSORT2 swissprot:BGAL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BGAL_ECOLI Pfam PF00703 http://pfam.xfam.org/family/PF00703 Pfam PF02836 http://pfam.xfam.org/family/PF02836 Pfam PF02837 http://pfam.xfam.org/family/PF02837 Pfam PF02929 http://pfam.xfam.org/family/PF02929 Pfam PF16353 http://pfam.xfam.org/family/PF16353 Phobius swissprot:BGAL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BGAL_ECOLI PhylomeDB P00722 http://phylomedb.org/?seqid=P00722 ProteinModelPortal P00722 http://www.proteinmodelportal.org/query/uniprot/P00722 PubMed 11045615 http://www.ncbi.nlm.nih.gov/pubmed/11045615 PubMed 11310566 http://www.ncbi.nlm.nih.gov/pubmed/11310566 PubMed 114210 http://www.ncbi.nlm.nih.gov/pubmed/114210 PubMed 11732897 http://www.ncbi.nlm.nih.gov/pubmed/11732897 PubMed 12578395 http://www.ncbi.nlm.nih.gov/pubmed/12578395 PubMed 1350782 http://www.ncbi.nlm.nih.gov/pubmed/1350782 PubMed 14621996 http://www.ncbi.nlm.nih.gov/pubmed/14621996 PubMed 15060622 http://www.ncbi.nlm.nih.gov/pubmed/15060622 PubMed 15950161 http://www.ncbi.nlm.nih.gov/pubmed/15950161 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17126292 http://www.ncbi.nlm.nih.gov/pubmed/17126292 PubMed 4562709 http://www.ncbi.nlm.nih.gov/pubmed/4562709 PubMed 6246435 http://www.ncbi.nlm.nih.gov/pubmed/6246435 PubMed 6313347 http://www.ncbi.nlm.nih.gov/pubmed/6313347 PubMed 6411710 http://www.ncbi.nlm.nih.gov/pubmed/6411710 PubMed 6420154 http://www.ncbi.nlm.nih.gov/pubmed/6420154 PubMed 6444453 http://www.ncbi.nlm.nih.gov/pubmed/6444453 PubMed 7577931 http://www.ncbi.nlm.nih.gov/pubmed/7577931 PubMed 8008071 http://www.ncbi.nlm.nih.gov/pubmed/8008071 PubMed 8662937 http://www.ncbi.nlm.nih.gov/pubmed/8662937 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9665715 http://www.ncbi.nlm.nih.gov/pubmed/9665715 PubMed 97298 http://www.ncbi.nlm.nih.gov/pubmed/97298 RefSeq NP_414878 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414878 RefSeq WP_000177906 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000177906 SMART SM01038 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01038 SMR P00722 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00722 STRING 511145.b0344 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0344&targetmode=cogs STRING COG3250 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3250&targetmode=cogs SUPFAM SSF49303 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49303 SUPFAM SSF49785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49785 SUPFAM SSF51445 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51445 SUPFAM SSF74650 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF74650 UniProtKB BGAL_ECOLI http://www.uniprot.org/uniprot/BGAL_ECOLI UniProtKB-AC P00722 http://www.uniprot.org/uniprot/P00722 charge swissprot:BGAL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BGAL_ECOLI eggNOG COG3250 http://eggnogapi.embl.de/nog_data/html/tree/COG3250 eggNOG ENOG4105CNT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CNT epestfind swissprot:BGAL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BGAL_ECOLI garnier swissprot:BGAL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BGAL_ECOLI helixturnhelix swissprot:BGAL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BGAL_ECOLI hmoment swissprot:BGAL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BGAL_ECOLI iep swissprot:BGAL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BGAL_ECOLI inforesidue swissprot:BGAL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BGAL_ECOLI octanol swissprot:BGAL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BGAL_ECOLI pepcoil swissprot:BGAL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BGAL_ECOLI pepdigest swissprot:BGAL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BGAL_ECOLI pepinfo swissprot:BGAL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BGAL_ECOLI pepnet swissprot:BGAL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BGAL_ECOLI pepstats swissprot:BGAL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BGAL_ECOLI pepwheel swissprot:BGAL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BGAL_ECOLI pepwindow swissprot:BGAL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BGAL_ECOLI sigcleave swissprot:BGAL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BGAL_ECOLI ## Database ID URL or Descriptions # EcoGene EG14488 yqeL # INDUCTION YQEL_ECOLI Constitutively expressed, induced at 45 degrees Celsius (at protein level). {ECO 0000269|PubMed 19121005, ECO 0000269|PubMed 19734316}. # Organism YQEL_ECOLI Escherichia coli (strain K12) # PATRIC 32121116 VBIEscCol129921_2947 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQEL_ECOLI Uncharacterized protein YqeL # RefSeq YP_002791253 NC_000913.3 BLAST swissprot:YQEL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQEL_ECOLI BioCyc EcoCyc:MONOMER0-2877 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2877 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2008.06495.x http://dx.doi.org/10.1111/j.1365-2958.2008.06495.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00872-09 http://dx.doi.org/10.1128/JB.00872-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14488 http://www.ecogene.org/geneInfo.php?eg_id=EG14488 EnsemblBacteria ACO60005 http://www.ensemblgenomes.org/id/ACO60005 EnsemblBacteria ACO60005 http://www.ensemblgenomes.org/id/ACO60005 EnsemblBacteria b4683 http://www.ensemblgenomes.org/id/b4683 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 7751637 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7751637 KEGG_Gene eco:b4683 http://www.genome.jp/dbget-bin/www_bget?eco:b4683 PSORT swissprot:YQEL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQEL_ECOLI PSORT-B swissprot:YQEL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQEL_ECOLI PSORT2 swissprot:YQEL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQEL_ECOLI Phobius swissprot:YQEL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQEL_ECOLI PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19121005 http://www.ncbi.nlm.nih.gov/pubmed/19121005 PubMed 19734316 http://www.ncbi.nlm.nih.gov/pubmed/19734316 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq YP_002791253 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_002791253 UniProtKB YQEL_ECOLI http://www.uniprot.org/uniprot/YQEL_ECOLI UniProtKB-AC C1P613 http://www.uniprot.org/uniprot/C1P613 charge swissprot:YQEL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQEL_ECOLI epestfind swissprot:YQEL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQEL_ECOLI garnier swissprot:YQEL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQEL_ECOLI helixturnhelix swissprot:YQEL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQEL_ECOLI hmoment swissprot:YQEL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQEL_ECOLI iep swissprot:YQEL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQEL_ECOLI inforesidue swissprot:YQEL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQEL_ECOLI octanol swissprot:YQEL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQEL_ECOLI pepcoil swissprot:YQEL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQEL_ECOLI pepdigest swissprot:YQEL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQEL_ECOLI pepinfo swissprot:YQEL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQEL_ECOLI pepnet swissprot:YQEL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQEL_ECOLI pepstats swissprot:YQEL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQEL_ECOLI pepwheel swissprot:YQEL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQEL_ECOLI pepwindow swissprot:YQEL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQEL_ECOLI sigcleave swissprot:YQEL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQEL_ECOLI ## Database ID URL or Descriptions # AltName GSP_ECOLI Glutathionylspermidine amidohydrolase [spermidine-forming] # AltName GSP_ECOLI Glutathionylspermidine amidohydrolase [spermidine-forming] # AltName GSP_ECOLI Gsp synthase # AltName Glutathione spermidine ligase [ADP-forming] # BIOPHYSICOCHEMICAL PROPERTIES GSP_ECOLI Kinetic parameters KM=100 uM for ATP (at pH 6.8) {ECO 0000269|PubMed 17124497, ECO 0000269|PubMed 7775463}; KM=800 uM for glutathione (at pH 6.8) {ECO 0000269|PubMed 17124497, ECO 0000269|PubMed 7775463}; KM=218 uM for glutathione {ECO 0000269|PubMed 17124497, ECO 0000269|PubMed 7775463}; KM=60 uM for spermidine (at pH 6.8) {ECO 0000269|PubMed 17124497, ECO 0000269|PubMed 7775463}; KM=20 uM for spermidine (at pH 7.5) {ECO 0000269|PubMed 17124497, ECO 0000269|PubMed 7775463}; KM=76 uM for spermidine {ECO 0000269|PubMed 17124497, ECO 0000269|PubMed 7775463}; KM=900 uM for glutathionylspermidine (at pH 7.5) {ECO 0000269|PubMed 17124497, ECO 0000269|PubMed 7775463}; Note=kcat is 7 sec(-1) for Gsp synthetase activity at pH 6.8 and 2.1 sec(-1) for Gsp amidase activity at pH 7.5. {ECO 0000269|PubMed 7775463}; pH dependence Optimum pH is around 6.8 for Gsp synthetase activity. {ECO 0000269|PubMed 7775463}; # BRENDA 3.5.1.78 2026 # BRENDA 6.3.1 2026 # BioGrid 4261180 14 # CATALYTIC ACTIVITY GSP_ECOLI Glutathione + spermidine + ATP = glutathionylspermidine + ADP + phosphate. {ECO 0000269|PubMed 20530482, ECO 0000269|PubMed 23097746, ECO 0000269|PubMed 7775463, ECO 0000269|PubMed 8999955}. # CATALYTIC ACTIVITY GSP_ECOLI Glutathionylspermidine + H(2)O = glutathione + spermidine. {ECO 0000269|PubMed 20530482, ECO 0000269|PubMed 23097746, ECO 0000269|PubMed 7775463, ECO 0000269|PubMed 8999955}. # DISRUPTION PHENOTYPE GSP_ECOLI Cells lacking this gene do not produce Gsp under anaerobic conditions. Cells lacking both this gene and glutaredoxin (grxA or grxB) become hypersensitive to H(2)O(2); they are even more susceptible to oxidative damage than the single mutant lacking glutaredoxin only. {ECO 0000269|PubMed 20530482, ECO 0000269|PubMed 23097746}. # DOMAIN GSP_ECOLI The two activities reside in distinct domains (N-terminal amidase and C-terminal synthetase). The two domains expressed independently are folded and functional; liberation of the amidase domain from the synthetase domain highly activates the amidase activity. {ECO 0000269|PubMed 17124497, ECO 0000269|PubMed 8999955}. # ENZYME REGULATION GSP_ECOLI When exposed to oxidative stress, Gsp amidase activity is transiently inhibited in vivo by oxidation of the catalytic Cys-59 thiol to sulfenic acid; this modification does not affect Gsp synthetase activity. Gsp amidase activity is negatively autoregulated by the Gsp synthetase domain, and is activated by the Gsp synthetase substrates, GSH and ATP-Mg(2+); the occupancy of the synthetase active site may initiate communication through the protein as manifest by the release of inhibition of the amidase activity. A tetrahedral phosphonate analog of glutathionylspermidine, designed as a mimic of the proposed tetrahedral intermediate for either reaction, inhibits the synthetase activity (Ki of 10 uM) but does not inhibit the amidase activity. Amidase activity is inhibited by iodoacetamide in vitro. {ECO 0000269|PubMed 20530482, ECO 0000269|PubMed 8999955, ECO 0000269|PubMed 9398217}. # EcoGene EG12882 gss # FUNCTION GSP_ECOLI Catalyzes the formation of an amide bond between glutathione (GSH) and spermidine coupled with hydrolysis of ATP; also catalyzes the opposing reaction, i.e. the hydrolysis of glutathionylspermidine (Gsp) back to glutathione and spermidine. The amidase active site can also hydrolyze Gsp-disulfide (Gsp-S-S- Gsp) to Gsp-SG and Gsp S-thiolated proteins (GspSSPs) to GSH S- thiolated protein (GSSPs). Likely acts synergistically with glutaredoxin to regulate the redox environment of E.coli and defend against oxidative damage. In vitro, the amidase active site also catalyzes hydrolysis of amide and ester derivatives of glutathione (e.g. glutathione ethyl ester and glutathione amide) but lacks activity toward acetylspermidine (N1 and N8) and acetylspermine (N1). {ECO 0000269|PubMed 20530482, ECO 0000269|PubMed 23097746, ECO 0000269|PubMed 7775463, ECO 0000269|PubMed 8999955}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0008884 glutathionylspermidine amidase activity; IDA:EcoCyc. # GO_function GO:0008885 glutathionylspermidine synthase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006749 glutathione metabolic process; IEA:UniProtKB-UniPathway. # GO_process GO:0008216 spermidine metabolic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # INDUCTION GSP_ECOLI Expression level is unaffected by H(2)O(2); however Gsp rapidly accumulates in E.coli in the presence of H(2)O(2). # INTERACTION GSP_ECOLI P31574 fixB; NbExp=2; IntAct=EBI-557080, EBI-554030; P0AG30 rho; NbExp=4; IntAct=EBI-557080, EBI-545468; # IntAct P0AES0 14 # InterPro IPR005494 GSPS_pre-ATP-grasp-like_dom # InterPro IPR007921 CHAP_dom # InterPro IPR016185 PreATP-grasp_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00480 Glutathione metabolism # MISCELLANEOUS GSP_ECOLI Gsp hydrolysis to GSH and spermidine proceeds with formation of a glutathionyl acyl-enzyme intermediate, utilizing a cysteine residue as the catalytic nucleophile (PubMed 9398217). For Gsp synthesis, GSH is likely phosphorylated at one of two GSH- binding sites to form an acylphosphate intermediate that then translocates to the other site for subsequent nucleophilic addition of spermidine (PubMed 17124497). {ECO 0000305|PubMed 17124497, ECO 0000305|PubMed 9398217}. # MISCELLANEOUS Gsp forms mixed disulfides with the thiols of a variety of E.coli proteins. These mixed disulfides represent a previously uncharacterized type of post-translational modification. The level of these proteins is increased by oxidative stress, which implies that Gsp might protect protein thiols against irreversible oxidation (PubMed:20530482). {ECO 0000305|PubMed:20530482}. # MISCELLANEOUS No metal ion is required for the amidase activity. {ECO:0000305|PubMed 8999955}. # Organism GSP_ECOLI Escherichia coli (strain K12) # PATHWAY GSP_ECOLI Amine and polyamine metabolism; spermidine metabolism. # PATHWAY GSP_ECOLI Sulfur metabolism; glutathione metabolism. # PATRIC 32121392 VBIEscCol129921_3083 # PDB 2IO7 X-ray; 2.70 A; A/B=1-619 # PDB 2IO8 X-ray; 2.10 A; A/B=1-619 # PDB 2IO9 X-ray; 2.20 A; A/B=1-619 # PDB 2IOA X-ray; 2.80 A; A/B=1-619 # PDB 2IOB X-ray; 2.20 A; A/B=1-619 # PDB 3A2Y X-ray; 1.95 A; A=1-197 # PDB 3A2Z X-ray; 1.50 A; A=1-197 # PDB 3A30 X-ray; 2.20 A; A=1-197 # PDB 3O98 X-ray; 2.80 A; A/B=1-619 # PIR A57538 A57538 # PROSITE PS50911 CHAP # PTM GSP_ECOLI Oxidation of Cys-59 to sulfenic acid during oxidative stress selectively inhibits the amidase activity which leads to a rapid increase in the amounts of intracellular Gsp and Gsp S-thiolated proteins (GspSSPs). {ECO 0000269|PubMed 20530482}. # Pfam PF03738 GSP_synth # Pfam PF05257 CHAP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GSP_ECOLI Bifunctional glutathionylspermidine synthetase/amidase # RecName GSP_ECOLI Glutathionylspermidine amidase # RecName GSP_ECOLI Glutathionylspermidine synthetase # RefSeq NP_417462 NC_000913.3 # RefSeq WP_001297309 NZ_LN832404.1 # SIMILARITY Contains 1 peptidase C51 domain. {ECO:0000255|PROSITE- ProRule PRU00048}. # SIMILARITY In the C-terminal section; belongs to the glutathionylspermidine synthase preATP-grasp family. {ECO 0000305}. # SUBUNIT GSP_ECOLI Homodimer. {ECO 0000269|PubMed 17124497, ECO 0000269|PubMed 7775463}. # SUPFAM SSF52440 SSF52440 # eggNOG COG0754 LUCA # eggNOG ENOG4106032 Bacteria BLAST swissprot:GSP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GSP_ECOLI BioCyc ECOL316407:JW2956-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2956-MONOMER BioCyc EcoCyc:GSP-MONOMER http://biocyc.org/getid?id=EcoCyc:GSP-MONOMER BioCyc MetaCyc:GSP-MONOMER http://biocyc.org/getid?id=MetaCyc:GSP-MONOMER COG COG0754 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0754 DIP DIP-36018N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36018N DOI 10.1002/pro.589 http://dx.doi.org/10.1002/pro.589 DOI 10.1021/bi9714464 http://dx.doi.org/10.1021/bi9714464 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/sj.emboj.7601440 http://dx.doi.org/10.1038/sj.emboj.7601440 DOI 10.1074/jbc.270.23.14031 http://dx.doi.org/10.1074/jbc.270.23.14031 DOI 10.1074/jbc.272.4.2429 http://dx.doi.org/10.1074/jbc.272.4.2429 DOI 10.1074/jbc.M110.133363 http://dx.doi.org/10.1074/jbc.M110.133363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.5.1.78 {ECO:0000269|PubMed:20530482, ECO:0000269|PubMed:23097746, ECO:0000269|PubMed:7775463, ECO:0000269|PubMed:8999955} http://www.genome.jp/dbget-bin/www_bget?EC:3.5.1.78 {ECO:0000269|PubMed:20530482, ECO:0000269|PubMed:23097746, ECO:0000269|PubMed:7775463, ECO:0000269|PubMed:8999955} EC_number EC:6.3.1.8 {ECO:0000269|PubMed:20530482, ECO:0000269|PubMed:23097746, ECO:0000269|PubMed:7775463, ECO:0000269|PubMed:8999955} http://www.genome.jp/dbget-bin/www_bget?EC:6.3.1.8 {ECO:0000269|PubMed:20530482, ECO:0000269|PubMed:23097746, ECO:0000269|PubMed:7775463, ECO:0000269|PubMed:8999955} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U23148 http://www.ebi.ac.uk/ena/data/view/U23148 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 ENZYME 3.5.1.78 {ECO:0000269|PubMed:20530482, ECO:0000269|PubMed:23097746, ECO:0000269|PubMed:7775463, ECO:0000269|PubMed:8999955} http://enzyme.expasy.org/EC/3.5.1.78 {ECO:0000269|PubMed:20530482, ECO:0000269|PubMed:23097746, ECO:0000269|PubMed:7775463, ECO:0000269|PubMed:8999955} ENZYME 6.3.1.8 {ECO:0000269|PubMed:20530482, ECO:0000269|PubMed:23097746, ECO:0000269|PubMed:7775463, ECO:0000269|PubMed:8999955} http://enzyme.expasy.org/EC/6.3.1.8 {ECO:0000269|PubMed:20530482, ECO:0000269|PubMed:23097746, ECO:0000269|PubMed:7775463, ECO:0000269|PubMed:8999955} EchoBASE EB2720 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2720 EcoGene EG12882 http://www.ecogene.org/geneInfo.php?eg_id=EG12882 EnsemblBacteria AAC76024 http://www.ensemblgenomes.org/id/AAC76024 EnsemblBacteria AAC76024 http://www.ensemblgenomes.org/id/AAC76024 EnsemblBacteria BAE77049 http://www.ensemblgenomes.org/id/BAE77049 EnsemblBacteria BAE77049 http://www.ensemblgenomes.org/id/BAE77049 EnsemblBacteria BAE77049 http://www.ensemblgenomes.org/id/BAE77049 EnsemblBacteria b2988 http://www.ensemblgenomes.org/id/b2988 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008884 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008884 GO_function GO:0008885 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008885 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006749 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006749 GO_process GO:0008216 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008216 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 947474 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947474 HOGENOM HOG000124980 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000124980&db=HOGENOM6 InParanoid P0AES0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AES0 IntAct P0AES0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AES0* IntEnz 3.5.1.78 {ECO:0000269|PubMed:20530482, ECO:0000269|PubMed:23097746, ECO:0000269|PubMed:7775463, ECO:0000269|PubMed:8999955} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.1.78 {ECO:0000269|PubMed:20530482, ECO:0000269|PubMed:23097746, ECO:0000269|PubMed:7775463, ECO:0000269|PubMed:8999955} IntEnz 6.3.1.8 {ECO:0000269|PubMed:20530482, ECO:0000269|PubMed:23097746, ECO:0000269|PubMed:7775463, ECO:0000269|PubMed:8999955} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.1.8 {ECO:0000269|PubMed:20530482, ECO:0000269|PubMed:23097746, ECO:0000269|PubMed:7775463, ECO:0000269|PubMed:8999955} InterPro IPR005494 http://www.ebi.ac.uk/interpro/entry/IPR005494 InterPro IPR007921 http://www.ebi.ac.uk/interpro/entry/IPR007921 InterPro IPR016185 http://www.ebi.ac.uk/interpro/entry/IPR016185 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2956 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2956 KEGG_Gene eco:b2988 http://www.genome.jp/dbget-bin/www_bget?eco:b2988 KEGG_Orthology KO:K01460 http://www.genome.jp/dbget-bin/www_bget?KO:K01460 KEGG_Pathway ko00480 http://www.genome.jp/kegg-bin/show_pathway?ko00480 KEGG_Reaction rn:R01917 http://www.genome.jp/dbget-bin/www_bget?rn:R01917 KEGG_Reaction rn:R01918 http://www.genome.jp/dbget-bin/www_bget?rn:R01918 MINT MINT-1234290 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1234290 OMA PNHRYLL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PNHRYLL PDB 2IO7 http://www.ebi.ac.uk/pdbe-srv/view/entry/2IO7 PDB 2IO8 http://www.ebi.ac.uk/pdbe-srv/view/entry/2IO8 PDB 2IO9 http://www.ebi.ac.uk/pdbe-srv/view/entry/2IO9 PDB 2IOA http://www.ebi.ac.uk/pdbe-srv/view/entry/2IOA PDB 2IOB http://www.ebi.ac.uk/pdbe-srv/view/entry/2IOB PDB 3A2Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3A2Y PDB 3A2Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3A2Z PDB 3A30 http://www.ebi.ac.uk/pdbe-srv/view/entry/3A30 PDB 3O98 http://www.ebi.ac.uk/pdbe-srv/view/entry/3O98 PDBsum 2IO7 http://www.ebi.ac.uk/pdbsum/2IO7 PDBsum 2IO8 http://www.ebi.ac.uk/pdbsum/2IO8 PDBsum 2IO9 http://www.ebi.ac.uk/pdbsum/2IO9 PDBsum 2IOA http://www.ebi.ac.uk/pdbsum/2IOA PDBsum 2IOB http://www.ebi.ac.uk/pdbsum/2IOB PDBsum 3A2Y http://www.ebi.ac.uk/pdbsum/3A2Y PDBsum 3A2Z http://www.ebi.ac.uk/pdbsum/3A2Z PDBsum 3A30 http://www.ebi.ac.uk/pdbsum/3A30 PDBsum 3O98 http://www.ebi.ac.uk/pdbsum/3O98 PROSITE PS50911 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50911 PSORT swissprot:GSP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GSP_ECOLI PSORT-B swissprot:GSP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GSP_ECOLI PSORT2 swissprot:GSP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GSP_ECOLI Pfam PF03738 http://pfam.xfam.org/family/PF03738 Pfam PF05257 http://pfam.xfam.org/family/PF05257 Phobius swissprot:GSP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GSP_ECOLI ProteinModelPortal P0AES0 http://www.proteinmodelportal.org/query/uniprot/P0AES0 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17124497 http://www.ncbi.nlm.nih.gov/pubmed/17124497 PubMed 20530482 http://www.ncbi.nlm.nih.gov/pubmed/20530482 PubMed 21226054 http://www.ncbi.nlm.nih.gov/pubmed/21226054 PubMed 23097746 http://www.ncbi.nlm.nih.gov/pubmed/23097746 PubMed 7775463 http://www.ncbi.nlm.nih.gov/pubmed/7775463 PubMed 8999955 http://www.ncbi.nlm.nih.gov/pubmed/8999955 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9398217 http://www.ncbi.nlm.nih.gov/pubmed/9398217 RefSeq NP_417462 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417462 RefSeq WP_001297309 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001297309 SMR P0AES0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AES0 STRING 511145.b2988 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2988&targetmode=cogs STRING COG0754 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0754&targetmode=cogs SUPFAM SSF52440 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52440 UniProtKB GSP_ECOLI http://www.uniprot.org/uniprot/GSP_ECOLI UniProtKB-AC P0AES0 http://www.uniprot.org/uniprot/P0AES0 charge swissprot:GSP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GSP_ECOLI eggNOG COG0754 http://eggnogapi.embl.de/nog_data/html/tree/COG0754 eggNOG ENOG4106032 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106032 epestfind swissprot:GSP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GSP_ECOLI garnier swissprot:GSP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GSP_ECOLI helixturnhelix swissprot:GSP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GSP_ECOLI hmoment swissprot:GSP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GSP_ECOLI iep swissprot:GSP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GSP_ECOLI inforesidue swissprot:GSP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GSP_ECOLI octanol swissprot:GSP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GSP_ECOLI pepcoil swissprot:GSP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GSP_ECOLI pepdigest swissprot:GSP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GSP_ECOLI pepinfo swissprot:GSP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GSP_ECOLI pepnet swissprot:GSP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GSP_ECOLI pepstats swissprot:GSP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GSP_ECOLI pepwheel swissprot:GSP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GSP_ECOLI pepwindow swissprot:GSP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GSP_ECOLI sigcleave swissprot:GSP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GSP_ECOLI ## Database ID URL or Descriptions # BioGrid 4260016 11 # EcoGene EG13703 ycbK # Gene3D 3.30.1380.10 -; 1. # IntAct P0AB06 9 # InterPro IPR006311 TAT_signal # InterPro IPR009045 Hedgehog_sig/DD-Pept_Zn-bd_dom # InterPro IPR010275 DUF882 # Organism YCBK_ECOLI Escherichia coli (strain K12) # PATRIC 32117065 VBIEscCol129921_0957 # PIR E64832 E64832 # PROSITE PS51318 TAT # PTM YCBK_ECOLI Exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven. # Pfam PF05951 Peptidase_M15_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCBK_ECOLI Uncharacterized protein YcbK # RefSeq NP_415446 NC_000913.3 # RefSeq WP_001295932 NZ_LN832404.1 # SIMILARITY To H.influenzae HI_1666. {ECO 0000305}. # SUPFAM SSF55166 SSF55166 # eggNOG COG3108 LUCA # eggNOG ENOG4105EAQ Bacteria BLAST swissprot:YCBK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCBK_ECOLI BioCyc ECOL316407:JW0909-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0909-MONOMER BioCyc EcoCyc:G6474-MONOMER http://biocyc.org/getid?id=EcoCyc:G6474-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M610507200 http://dx.doi.org/10.1074/jbc.M610507200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3467 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3467 EcoGene EG13703 http://www.ecogene.org/geneInfo.php?eg_id=EG13703 EnsemblBacteria AAC74012 http://www.ensemblgenomes.org/id/AAC74012 EnsemblBacteria AAC74012 http://www.ensemblgenomes.org/id/AAC74012 EnsemblBacteria BAA35672 http://www.ensemblgenomes.org/id/BAA35672 EnsemblBacteria BAA35672 http://www.ensemblgenomes.org/id/BAA35672 EnsemblBacteria BAA35672 http://www.ensemblgenomes.org/id/BAA35672 EnsemblBacteria b0926 http://www.ensemblgenomes.org/id/b0926 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.30.1380.10 http://www.cathdb.info/version/latest/superfamily/3.30.1380.10 GeneID 945538 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945538 HOGENOM HOG000273967 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000273967&db=HOGENOM6 InParanoid P0AB06 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AB06 IntAct P0AB06 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AB06* InterPro IPR006311 http://www.ebi.ac.uk/interpro/entry/IPR006311 InterPro IPR009045 http://www.ebi.ac.uk/interpro/entry/IPR009045 InterPro IPR010275 http://www.ebi.ac.uk/interpro/entry/IPR010275 KEGG_Gene ecj:JW0909 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0909 KEGG_Gene eco:b0926 http://www.genome.jp/dbget-bin/www_bget?eco:b0926 OMA KKSYHMK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KKSYHMK PROSITE PS51318 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51318 PSORT swissprot:YCBK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCBK_ECOLI PSORT-B swissprot:YCBK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCBK_ECOLI PSORT2 swissprot:YCBK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCBK_ECOLI Pfam PF05951 http://pfam.xfam.org/family/PF05951 Phobius swissprot:YCBK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCBK_ECOLI PhylomeDB P0AB06 http://phylomedb.org/?seqid=P0AB06 ProteinModelPortal P0AB06 http://www.proteinmodelportal.org/query/uniprot/P0AB06 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17218314 http://www.ncbi.nlm.nih.gov/pubmed/17218314 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415446 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415446 RefSeq WP_001295932 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295932 STRING 511145.b0926 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0926&targetmode=cogs SUPFAM SSF55166 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55166 UniProtKB YCBK_ECOLI http://www.uniprot.org/uniprot/YCBK_ECOLI UniProtKB-AC P0AB06 http://www.uniprot.org/uniprot/P0AB06 charge swissprot:YCBK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCBK_ECOLI eggNOG COG3108 http://eggnogapi.embl.de/nog_data/html/tree/COG3108 eggNOG ENOG4105EAQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EAQ epestfind swissprot:YCBK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCBK_ECOLI garnier swissprot:YCBK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCBK_ECOLI helixturnhelix swissprot:YCBK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCBK_ECOLI hmoment swissprot:YCBK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCBK_ECOLI iep swissprot:YCBK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCBK_ECOLI inforesidue swissprot:YCBK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCBK_ECOLI octanol swissprot:YCBK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCBK_ECOLI pepcoil swissprot:YCBK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCBK_ECOLI pepdigest swissprot:YCBK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCBK_ECOLI pepinfo swissprot:YCBK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCBK_ECOLI pepnet swissprot:YCBK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCBK_ECOLI pepstats swissprot:YCBK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCBK_ECOLI pepwheel swissprot:YCBK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCBK_ECOLI pepwindow swissprot:YCBK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCBK_ECOLI sigcleave swissprot:YCBK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCBK_ECOLI ## Database ID URL or Descriptions # BioGrid 4260256 115 # EcoGene EG12457 ydgA # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GOslim_component GO:0005886 plasma membrane # INTERACTION YDGA_ECOLI Self; NbExp=2; IntAct=EBI-552466, EBI-552466; # IntAct P77804 11 # InterPro IPR010352 DUF945 # Organism YDGA_ECOLI Escherichia coli (strain K12) # PATRIC 32118530 VBIEscCol129921_1685 # PIR H64917 H64917 # Pfam PF06097 DUF945 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDGA_ECOLI Protein YdgA # RefSeq NP_416131 NC_000913.3 # RefSeq WP_001043339 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA68926.1; Type=Frameshift; Positions=422; Evidence={ECO 0000305}; # SIMILARITY To E.coli YihF and H.influenzae HI_1236. {ECO 0000305}. # SUBCELLULAR LOCATION YDGA_ECOLI Cell inner membrane {ECO 0000269|PubMed 16079137}; Peripheral membrane protein {ECO 0000269|PubMed 16079137}; Periplasmic side {ECO 0000269|PubMed 16079137}. Note=Has been isolated in association with the inner membrane, suggesting it may be tethered to the membrane. # SUBUNIT Homodimer. {ECO:0000269|PubMed 16079137}. # eggNOG COG5339 LUCA # eggNOG ENOG4106J39 Bacteria BLAST swissprot:YDGA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDGA_ECOLI BioCyc ECOL316407:JW1606-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1606-MONOMER BioCyc EcoCyc:G6865-MONOMER http://biocyc.org/getid?id=EcoCyc:G6865-MONOMER DIP DIP-11709N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11709N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M14641 http://www.ebi.ac.uk/ena/data/view/M14641 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2351 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2351 EcoGene EG12457 http://www.ecogene.org/geneInfo.php?eg_id=EG12457 EnsemblBacteria AAC74686 http://www.ensemblgenomes.org/id/AAC74686 EnsemblBacteria AAC74686 http://www.ensemblgenomes.org/id/AAC74686 EnsemblBacteria BAA15362 http://www.ensemblgenomes.org/id/BAA15362 EnsemblBacteria BAA15362 http://www.ensemblgenomes.org/id/BAA15362 EnsemblBacteria BAA15362 http://www.ensemblgenomes.org/id/BAA15362 EnsemblBacteria b1614 http://www.ensemblgenomes.org/id/b1614 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 946172 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946172 HOGENOM HOG000120874 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120874&db=HOGENOM6 IntAct P77804 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77804* InterPro IPR010352 http://www.ebi.ac.uk/interpro/entry/IPR010352 KEGG_Gene ecj:JW1606 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1606 KEGG_Gene eco:b1614 http://www.genome.jp/dbget-bin/www_bget?eco:b1614 MINT MINT-1239915 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1239915 OMA QYANGQV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QYANGQV PSORT swissprot:YDGA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDGA_ECOLI PSORT-B swissprot:YDGA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDGA_ECOLI PSORT2 swissprot:YDGA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDGA_ECOLI Pfam PF06097 http://pfam.xfam.org/family/PF06097 Phobius swissprot:YDGA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDGA_ECOLI ProteinModelPortal P77804 http://www.proteinmodelportal.org/query/uniprot/P77804 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416131 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416131 RefSeq WP_001043339 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001043339 STRING 511145.b1614 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1614&targetmode=cogs UniProtKB YDGA_ECOLI http://www.uniprot.org/uniprot/YDGA_ECOLI UniProtKB-AC P77804 http://www.uniprot.org/uniprot/P77804 charge swissprot:YDGA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDGA_ECOLI eggNOG COG5339 http://eggnogapi.embl.de/nog_data/html/tree/COG5339 eggNOG ENOG4106J39 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106J39 epestfind swissprot:YDGA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDGA_ECOLI garnier swissprot:YDGA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDGA_ECOLI helixturnhelix swissprot:YDGA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDGA_ECOLI hmoment swissprot:YDGA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDGA_ECOLI iep swissprot:YDGA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDGA_ECOLI inforesidue swissprot:YDGA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDGA_ECOLI octanol swissprot:YDGA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDGA_ECOLI pepcoil swissprot:YDGA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDGA_ECOLI pepdigest swissprot:YDGA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDGA_ECOLI pepinfo swissprot:YDGA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDGA_ECOLI pepnet swissprot:YDGA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDGA_ECOLI pepstats swissprot:YDGA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDGA_ECOLI pepwheel swissprot:YDGA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDGA_ECOLI pepwindow swissprot:YDGA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDGA_ECOLI sigcleave swissprot:YDGA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDGA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260200 14 # EcoGene EG13777 yncG # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0004364 glutathione transferase activity; IBA:GO_Central. # GO_process GO:0006749 glutathione metabolic process; IBA:GO_Central. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.20.1050.10 -; 1. # Gene3D 3.40.30.10 -; 1. # IntAct P76117 3 # InterPro IPR004045 Glutathione_S-Trfase_N # InterPro IPR010987 Glutathione-S-Trfase_C-like # InterPro IPR012336 Thioredoxin-like_fold # Organism YNCG_ECOLI Escherichia coli (strain K12) # PATRIC 32118200 VBIEscCol129921_1520 # PIR A64898 A64898 # PROSITE PS50404 GST_NTER # PROSITE PS50405 GST_CTER # Pfam PF13417 GST_N_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNCG_ECOLI Uncharacterized GST-like protein YncG # RefSeq NP_415971 NC_000913.3 # RefSeq WP_000598857 NZ_LN832404.1 # SIMILARITY Belongs to the GST superfamily. Beta family. {ECO 0000305}. # SIMILARITY Contains 1 GST C-terminal domain. {ECO 0000305}. # SIMILARITY Contains 1 GST N-terminal domain. {ECO 0000305}. # SUPFAM SSF47616 SSF47616 # SUPFAM SSF52833 SSF52833 # eggNOG COG0625 LUCA # eggNOG ENOG4108N27 Bacteria BLAST swissprot:YNCG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNCG_ECOLI BioCyc ECOL316407:JW1449-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1449-MONOMER BioCyc EcoCyc:G6765-MONOMER http://biocyc.org/getid?id=EcoCyc:G6765-MONOMER COG COG0625 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0625 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3539 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3539 EcoGene EG13777 http://www.ecogene.org/geneInfo.php?eg_id=EG13777 EnsemblBacteria AAC74536 http://www.ensemblgenomes.org/id/AAC74536 EnsemblBacteria AAC74536 http://www.ensemblgenomes.org/id/AAC74536 EnsemblBacteria BAE76446 http://www.ensemblgenomes.org/id/BAE76446 EnsemblBacteria BAE76446 http://www.ensemblgenomes.org/id/BAE76446 EnsemblBacteria BAE76446 http://www.ensemblgenomes.org/id/BAE76446 EnsemblBacteria b1454 http://www.ensemblgenomes.org/id/b1454 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004364 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004364 GO_process GO:0006749 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006749 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016765 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.20.1050.10 http://www.cathdb.info/version/latest/superfamily/1.20.1050.10 Gene3D 3.40.30.10 http://www.cathdb.info/version/latest/superfamily/3.40.30.10 GeneID 946023 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946023 HOGENOM HOG000125750 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125750&db=HOGENOM6 InParanoid P76117 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76117 IntAct P76117 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76117* InterPro IPR004045 http://www.ebi.ac.uk/interpro/entry/IPR004045 InterPro IPR010987 http://www.ebi.ac.uk/interpro/entry/IPR010987 InterPro IPR012336 http://www.ebi.ac.uk/interpro/entry/IPR012336 KEGG_Gene ecj:JW1449 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1449 KEGG_Gene eco:b1454 http://www.genome.jp/dbget-bin/www_bget?eco:b1454 KEGG_Orthology KO:K11208 http://www.genome.jp/dbget-bin/www_bget?KO:K11208 OMA ISEMMLT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ISEMMLT PROSITE PS50404 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50404 PROSITE PS50405 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50405 PSORT swissprot:YNCG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNCG_ECOLI PSORT-B swissprot:YNCG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNCG_ECOLI PSORT2 swissprot:YNCG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNCG_ECOLI Pfam PF13417 http://pfam.xfam.org/family/PF13417 Phobius swissprot:YNCG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNCG_ECOLI PhylomeDB P76117 http://phylomedb.org/?seqid=P76117 ProteinModelPortal P76117 http://www.proteinmodelportal.org/query/uniprot/P76117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415971 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415971 RefSeq WP_000598857 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000598857 SMR P76117 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76117 STRING 511145.b1454 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1454&targetmode=cogs STRING COG0625 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0625&targetmode=cogs SUPFAM SSF47616 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47616 SUPFAM SSF52833 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52833 UniProtKB YNCG_ECOLI http://www.uniprot.org/uniprot/YNCG_ECOLI UniProtKB-AC P76117 http://www.uniprot.org/uniprot/P76117 charge swissprot:YNCG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNCG_ECOLI eggNOG COG0625 http://eggnogapi.embl.de/nog_data/html/tree/COG0625 eggNOG ENOG4108N27 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108N27 epestfind swissprot:YNCG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNCG_ECOLI garnier swissprot:YNCG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNCG_ECOLI helixturnhelix swissprot:YNCG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNCG_ECOLI hmoment swissprot:YNCG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNCG_ECOLI iep swissprot:YNCG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNCG_ECOLI inforesidue swissprot:YNCG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNCG_ECOLI octanol swissprot:YNCG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNCG_ECOLI pepcoil swissprot:YNCG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNCG_ECOLI pepdigest swissprot:YNCG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNCG_ECOLI pepinfo swissprot:YNCG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNCG_ECOLI pepnet swissprot:YNCG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNCG_ECOLI pepstats swissprot:YNCG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNCG_ECOLI pepwheel swissprot:YNCG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNCG_ECOLI pepwindow swissprot:YNCG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNCG_ECOLI sigcleave swissprot:YNCG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNCG_ECOLI ## Database ID URL or Descriptions # AltName TCDA_ECOLI t(6)A37 dehydratase # BioGrid 4261127 823 # DISRUPTION PHENOTYPE TCDA_ECOLI Cells lacking this gene have a normal growth phenotype, but are unable to survive in a competitive growth situation with the wild-type strain. They display only the t(6)A but not the ct(6)A modification in tRNAs, and have lower decoding efficiency than wild-type. They show no defects in motility or antibiotic sensitivity. In growth competition experiments, a tcdA mutant shows reduced fitness compared to wild-type, but outcompetes a csdA mutant. {ECO 0000269|PubMed 20054882, ECO 0000269|PubMed 23242255}. # EcoGene EG13084 tcdA # FUNCTION TCDA_ECOLI Catalyzes the ATP-dependent dehydration of threonylcarbamoyladenosine at position 37 (t(6)A37) to form cyclic t(6)A37 (ct(6)A37) in tRNAs that read codons beginning with adenine. TcdA is also part of a sulfur transfer pathway; is able to accept sulfur from CsdA directly in vitro, but CsdE might act as the sulfur donor in vivo. {ECO 0000269|PubMed 20054882, ECO 0000269|PubMed 23242255}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0008641 small protein activating enzyme activity; IEA:InterPro. # GO_function GO:0030955 potassium ion binding; IDA:EcoCyc. # GO_function GO:0031402 sodium ion binding; IDA:EcoCyc. # GO_function GO:0061503 tRNA threonylcarbamoyladenosine dehydratase; IDA:EcoCyc. # GO_process GO:0061504 cyclic threonylcarbamoyladenosine biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # Gene3D 3.40.50.720 -; 1. # INTERACTION TCDA_ECOLI P0AGF2 csdE; NbExp=3; IntAct=EBI-1130463, EBI-1130454; # IntAct Q46927 9 # InterPro IPR000594 ThiF_NAD_FAD-bd # InterPro IPR016040 NAD(P)-bd_dom # MISCELLANEOUS ct(6)A is involved in promoting decoding efficiency. It is an unstable modification that can be easily hydrolyzed and converted to t(6)A during nucleoside preparation by conventional methods (PubMed:23242255). This explains why it was descibed as t(6)A37 in earlier studies. {ECO 0000305|PubMed:23242255}. # Organism TCDA_ECOLI Escherichia coli (strain K12) # PATRIC 32121040 VBIEscCol129921_2912 # PDB 4D79 X-ray; 1.77 A; A/B/C/D=1-268 # PDB 4D7A X-ray; 1.80 A; A/B/C/D=1-268 # PDB 4RDH X-ray; 2.10 A; A/B/C/D=1-268 # PDB 4RDI X-ray; 1.95 A; A/B/C/D=1-268 # PDB 4YED X-ray; 1.90 A; A/B/C/D=1-268 # PIR H65063 H65063 # Pfam PF00899 ThiF # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TCDA_ECOLI tRNA threonylcarbamoyladenosine dehydratase # RefSeq NP_417292 NC_000913.3 # RefSeq WP_000117728 NZ_LN832404.1 # SIMILARITY Belongs to the HesA/MoeB/ThiF family. {ECO 0000305}. # SUBCELLULAR LOCATION TCDA_ECOLI Membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. # SUBUNIT Interacts with CsdE. {ECO:0000269|PubMed 20054882}. # SUPFAM SSF69572 SSF69572 # eggNOG COG1179 LUCA # eggNOG ENOG4105CUZ Bacteria BLAST swissprot:TCDA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TCDA_ECOLI BioCyc ECOL316407:JW2783-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2783-MONOMER BioCyc EcoCyc:G7456-MONOMER http://biocyc.org/getid?id=EcoCyc:G7456-MONOMER BioCyc MetaCyc:G7456-MONOMER http://biocyc.org/getid?id=MetaCyc:G7456-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nchembio.1137 http://dx.doi.org/10.1038/nchembio.1137 DOI 10.1111/j.1365-2958.2009.06954.x http://dx.doi.org/10.1111/j.1365-2958.2009.06954.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.1.-.- http://www.genome.jp/dbget-bin/www_bget?EC:6.1.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 ENZYME 6.1.-.- http://enzyme.expasy.org/EC/6.1.-.- EchoBASE EB2893 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2893 EcoGene EG13084 http://www.ecogene.org/geneInfo.php?eg_id=EG13084 EnsemblBacteria AAC75854 http://www.ensemblgenomes.org/id/AAC75854 EnsemblBacteria AAC75854 http://www.ensemblgenomes.org/id/AAC75854 EnsemblBacteria BAE76884 http://www.ensemblgenomes.org/id/BAE76884 EnsemblBacteria BAE76884 http://www.ensemblgenomes.org/id/BAE76884 EnsemblBacteria BAE76884 http://www.ensemblgenomes.org/id/BAE76884 EnsemblBacteria b2812 http://www.ensemblgenomes.org/id/b2812 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008641 GO_function GO:0030955 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030955 GO_function GO:0031402 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031402 GO_function GO:0061503 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061503 GO_process GO:0061504 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061504 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 947291 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947291 HOGENOM HOG000263839 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000263839&db=HOGENOM6 InParanoid Q46927 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46927 IntAct Q46927 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46927* IntEnz 6.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.1 InterPro IPR000594 http://www.ebi.ac.uk/interpro/entry/IPR000594 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 KEGG_Gene ecj:JW2783 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2783 KEGG_Gene eco:b2812 http://www.genome.jp/dbget-bin/www_bget?eco:b2812 OMA DMDDICV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DMDDICV PDB 4D79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4D79 PDB 4D7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4D7A PDB 4RDH http://www.ebi.ac.uk/pdbe-srv/view/entry/4RDH PDB 4RDI http://www.ebi.ac.uk/pdbe-srv/view/entry/4RDI PDB 4YED http://www.ebi.ac.uk/pdbe-srv/view/entry/4YED PDBsum 4D79 http://www.ebi.ac.uk/pdbsum/4D79 PDBsum 4D7A http://www.ebi.ac.uk/pdbsum/4D7A PDBsum 4RDH http://www.ebi.ac.uk/pdbsum/4RDH PDBsum 4RDI http://www.ebi.ac.uk/pdbsum/4RDI PDBsum 4YED http://www.ebi.ac.uk/pdbsum/4YED PSORT swissprot:TCDA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TCDA_ECOLI PSORT-B swissprot:TCDA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TCDA_ECOLI PSORT2 swissprot:TCDA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TCDA_ECOLI Pfam PF00899 http://pfam.xfam.org/family/PF00899 Phobius swissprot:TCDA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TCDA_ECOLI PhylomeDB Q46927 http://phylomedb.org/?seqid=Q46927 ProteinModelPortal Q46927 http://www.proteinmodelportal.org/query/uniprot/Q46927 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20054882 http://www.ncbi.nlm.nih.gov/pubmed/20054882 PubMed 23242255 http://www.ncbi.nlm.nih.gov/pubmed/23242255 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417292 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417292 RefSeq WP_000117728 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000117728 SMR Q46927 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46927 STRING 511145.b2812 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2812&targetmode=cogs SUPFAM SSF69572 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF69572 UniProtKB TCDA_ECOLI http://www.uniprot.org/uniprot/TCDA_ECOLI UniProtKB-AC Q46927 http://www.uniprot.org/uniprot/Q46927 charge swissprot:TCDA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TCDA_ECOLI eggNOG COG1179 http://eggnogapi.embl.de/nog_data/html/tree/COG1179 eggNOG ENOG4105CUZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CUZ epestfind swissprot:TCDA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TCDA_ECOLI garnier swissprot:TCDA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TCDA_ECOLI helixturnhelix swissprot:TCDA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TCDA_ECOLI hmoment swissprot:TCDA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TCDA_ECOLI iep swissprot:TCDA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TCDA_ECOLI inforesidue swissprot:TCDA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TCDA_ECOLI octanol swissprot:TCDA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TCDA_ECOLI pepcoil swissprot:TCDA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TCDA_ECOLI pepdigest swissprot:TCDA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TCDA_ECOLI pepinfo swissprot:TCDA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TCDA_ECOLI pepnet swissprot:TCDA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TCDA_ECOLI pepstats swissprot:TCDA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TCDA_ECOLI pepwheel swissprot:TCDA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TCDA_ECOLI pepwindow swissprot:TCDA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TCDA_ECOLI sigcleave swissprot:TCDA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TCDA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260187 10 # EcoGene EG14300 yncJ # InterPro IPR020117 Uncharacterised_YncJ # Organism YNCJ_ECOLI Escherichia coli (strain K12) # PATRIC 32118162 VBIEscCol129921_1501 # PIR G64895 G64895 # Pfam PF10829 DUF2554 # ProDom PD057831 Uncharacterised_YncJ # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNCJ_ECOLI Uncharacterized protein YncJ # RefSeq NP_415953 NC_000913.3 # eggNOG ENOG4105RR0 Bacteria # eggNOG ENOG41120CN LUCA BLAST swissprot:YNCJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNCJ_ECOLI BioCyc ECOL316407:JW1432-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1432-MONOMER BioCyc EcoCyc:G6747-MONOMER http://biocyc.org/getid?id=EcoCyc:G6747-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4047 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4047 EcoGene EG14300 http://www.ecogene.org/geneInfo.php?eg_id=EG14300 EnsemblBacteria AAC74518 http://www.ensemblgenomes.org/id/AAC74518 EnsemblBacteria AAC74518 http://www.ensemblgenomes.org/id/AAC74518 EnsemblBacteria BAE76437 http://www.ensemblgenomes.org/id/BAE76437 EnsemblBacteria BAE76437 http://www.ensemblgenomes.org/id/BAE76437 EnsemblBacteria BAE76437 http://www.ensemblgenomes.org/id/BAE76437 EnsemblBacteria b1436 http://www.ensemblgenomes.org/id/b1436 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945990 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945990 HOGENOM HOG000267915 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267915&db=HOGENOM6 InterPro IPR020117 http://www.ebi.ac.uk/interpro/entry/IPR020117 KEGG_Gene ecj:JW1432 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1432 KEGG_Gene eco:b1436 http://www.genome.jp/dbget-bin/www_bget?eco:b1436 OMA LWVKNVD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LWVKNVD PSORT swissprot:YNCJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNCJ_ECOLI PSORT-B swissprot:YNCJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNCJ_ECOLI PSORT2 swissprot:YNCJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNCJ_ECOLI Pfam PF10829 http://pfam.xfam.org/family/PF10829 Phobius swissprot:YNCJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNCJ_ECOLI ProteinModelPortal P64459 http://www.proteinmodelportal.org/query/uniprot/P64459 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415953 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415953 SMR P64459 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P64459 STRING 511145.b1436 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1436&targetmode=cogs UniProtKB YNCJ_ECOLI http://www.uniprot.org/uniprot/YNCJ_ECOLI UniProtKB-AC P64459 http://www.uniprot.org/uniprot/P64459 charge swissprot:YNCJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNCJ_ECOLI eggNOG ENOG4105RR0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105RR0 eggNOG ENOG41120CN http://eggnogapi.embl.de/nog_data/html/tree/ENOG41120CN epestfind swissprot:YNCJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNCJ_ECOLI garnier swissprot:YNCJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNCJ_ECOLI helixturnhelix swissprot:YNCJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNCJ_ECOLI hmoment swissprot:YNCJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNCJ_ECOLI iep swissprot:YNCJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNCJ_ECOLI inforesidue swissprot:YNCJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNCJ_ECOLI octanol swissprot:YNCJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNCJ_ECOLI pepcoil swissprot:YNCJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNCJ_ECOLI pepdigest swissprot:YNCJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNCJ_ECOLI pepinfo swissprot:YNCJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNCJ_ECOLI pepnet swissprot:YNCJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNCJ_ECOLI pepstats swissprot:YNCJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNCJ_ECOLI pepwheel swissprot:YNCJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNCJ_ECOLI pepwindow swissprot:YNCJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNCJ_ECOLI sigcleave swissprot:YNCJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNCJ_ECOLI ## Database ID URL or Descriptions # AltName RIHA_ECOLI Cytidine/uridine-specific hydrolase # BioGrid 4261645 12 # ENZYME REGULATION RIHA_ECOLI Subject to catabolite repression. # EcoGene EG12701 rihA # FUNCTION RIHA_ECOLI Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0005509 calcium ion binding; IDA:EcoliWiki. # GO_function GO:0008477 purine nucleosidase activity; IBA:GO_Central. # GO_function GO:0045437 uridine nucleosidase activity; IDA:EcoCyc. # GO_function GO:0047405 pyrimidine-5'-nucleotide nucleosidase activity; IDA:EcoliWiki. # GO_process GO:0006152 purine nucleoside catabolic process; IBA:GO_Central. # GO_process GO:0006206 pyrimidine nucleobase metabolic process; IEA:UniProtKB-HAMAP. # GO_process GO:0015949 nucleobase-containing small molecule interconversion; IEA:InterPro. # GO_process GO:0046133 pyrimidine ribonucleoside catabolic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.90.245.10 -; 1. # HAMAP MF_01431 Pyrim_hydro_RihA # IntAct P41409 15 # InterPro IPR001910 Inosine/uridine_hydrolase_dom # InterPro IPR015910 I/U_nuclsd_hydro_CS # InterPro IPR022975 Pyrim_hydro_RihA # InterPro IPR023186 Inosine/uridine_hydrolase # KEGG_Brite ko01000 Enzymes # MISCELLANEOUS RIHA_ECOLI Strictly specific for ribonucleosides. # Organism RIHA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR12304 PTHR12304 # PATRIC 32116485 VBIEscCol129921_0682 # PDB 1YOE X-ray; 1.78 A; A=2-311 # PDB 3G5I X-ray; 2.10 A; A/B/C/D=2-311 # PIR A64800 A64800 # PROSITE PS01247 IUNH # Pfam PF01156 IU_nuc_hydro # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RIHA_ECOLI Pyrimidine-specific ribonucleoside hydrolase RihA # RefSeq NP_415184 NC_000913.3 # RefSeq WP_001207520 NZ_LN832404.1 # SIMILARITY Belongs to the IUNH family. RihA subfamily. {ECO 0000305}. # SUPFAM SSF53590 SSF53590 # eggNOG COG1957 LUCA # eggNOG ENOG4105DU0 Bacteria BLAST swissprot:RIHA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RIHA_ECOLI BioCyc ECOL316407:JW0646-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0646-MONOMER BioCyc EcoCyc:G6358-MONOMER http://biocyc.org/getid?id=EcoCyc:G6358-MONOMER BioCyc MetaCyc:G6358-MONOMER http://biocyc.org/getid?id=MetaCyc:G6358-MONOMER COG COG1957 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1957 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M008300200 http://dx.doi.org/10.1074/jbc.M008300200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.2.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.2.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U10981 http://www.ebi.ac.uk/ena/data/view/U10981 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 ENZYME 3.2.-.- http://enzyme.expasy.org/EC/3.2.-.- EchoBASE EB2563 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2563 EcoGene EG12701 http://www.ecogene.org/geneInfo.php?eg_id=EG12701 EnsemblBacteria AAC73752 http://www.ensemblgenomes.org/id/AAC73752 EnsemblBacteria AAC73752 http://www.ensemblgenomes.org/id/AAC73752 EnsemblBacteria BAA35303 http://www.ensemblgenomes.org/id/BAA35303 EnsemblBacteria BAA35303 http://www.ensemblgenomes.org/id/BAA35303 EnsemblBacteria BAA35303 http://www.ensemblgenomes.org/id/BAA35303 EnsemblBacteria b0651 http://www.ensemblgenomes.org/id/b0651 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0005509 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509 GO_function GO:0008477 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008477 GO_function GO:0045437 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045437 GO_function GO:0047405 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047405 GO_process GO:0006152 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006152 GO_process GO:0006206 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006206 GO_process GO:0015949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015949 GO_process GO:0046133 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046133 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.90.245.10 http://www.cathdb.info/version/latest/superfamily/3.90.245.10 GeneID 945503 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945503 HAMAP MF_01431 http://hamap.expasy.org/unirule/MF_01431 HOGENOM HOG000218839 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218839&db=HOGENOM6 InParanoid P41409 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P41409 IntAct P41409 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P41409* IntEnz 3.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.2 InterPro IPR001910 http://www.ebi.ac.uk/interpro/entry/IPR001910 InterPro IPR015910 http://www.ebi.ac.uk/interpro/entry/IPR015910 InterPro IPR022975 http://www.ebi.ac.uk/interpro/entry/IPR022975 InterPro IPR023186 http://www.ebi.ac.uk/interpro/entry/IPR023186 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0646 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0646 KEGG_Gene eco:b0651 http://www.genome.jp/dbget-bin/www_bget?eco:b0651 KEGG_Orthology KO:K01250 http://www.genome.jp/dbget-bin/www_bget?KO:K01250 OMA FLGRHIN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FLGRHIN PANTHER PTHR12304 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12304 PDB 1YOE http://www.ebi.ac.uk/pdbe-srv/view/entry/1YOE PDB 3G5I http://www.ebi.ac.uk/pdbe-srv/view/entry/3G5I PDBsum 1YOE http://www.ebi.ac.uk/pdbsum/1YOE PDBsum 3G5I http://www.ebi.ac.uk/pdbsum/3G5I PROSITE PS01247 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01247 PSORT swissprot:RIHA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RIHA_ECOLI PSORT-B swissprot:RIHA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RIHA_ECOLI PSORT2 swissprot:RIHA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RIHA_ECOLI Pfam PF01156 http://pfam.xfam.org/family/PF01156 Phobius swissprot:RIHA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RIHA_ECOLI PhylomeDB P41409 http://phylomedb.org/?seqid=P41409 ProteinModelPortal P41409 http://www.proteinmodelportal.org/query/uniprot/P41409 PubMed 11027694 http://www.ncbi.nlm.nih.gov/pubmed/11027694 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415184 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415184 RefSeq WP_001207520 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001207520 SMR P41409 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P41409 STRING 511145.b0651 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0651&targetmode=cogs STRING COG1957 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1957&targetmode=cogs SUPFAM SSF53590 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53590 UniProtKB RIHA_ECOLI http://www.uniprot.org/uniprot/RIHA_ECOLI UniProtKB-AC P41409 http://www.uniprot.org/uniprot/P41409 charge swissprot:RIHA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RIHA_ECOLI eggNOG COG1957 http://eggnogapi.embl.de/nog_data/html/tree/COG1957 eggNOG ENOG4105DU0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DU0 epestfind swissprot:RIHA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RIHA_ECOLI garnier swissprot:RIHA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RIHA_ECOLI helixturnhelix swissprot:RIHA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RIHA_ECOLI hmoment swissprot:RIHA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RIHA_ECOLI iep swissprot:RIHA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RIHA_ECOLI inforesidue swissprot:RIHA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RIHA_ECOLI octanol swissprot:RIHA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RIHA_ECOLI pepcoil swissprot:RIHA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RIHA_ECOLI pepdigest swissprot:RIHA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RIHA_ECOLI pepinfo swissprot:RIHA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RIHA_ECOLI pepnet swissprot:RIHA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RIHA_ECOLI pepstats swissprot:RIHA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RIHA_ECOLI pepwheel swissprot:RIHA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RIHA_ECOLI pepwindow swissprot:RIHA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RIHA_ECOLI sigcleave swissprot:RIHA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RIHA_ECOLI ## Database ID URL or Descriptions # AltName THTM_ECOLI Rhodanese-like protein # BRENDA 2.8.1 2026 # BioGrid 4260592 12 # CATALYTIC ACTIVITY THTM_ECOLI 3-mercaptopyruvate + cyanide = pyruvate + thiocyanate. # DOMAIN THTM_ECOLI Contains two rhodanese domains with different primary structures but with near identical secondary structure conformations suggesting a common evolutionary origin. Only the C- terminal rhodanese domain contains the catalytic cysteine residue (By similarity). {ECO 0000250}. # DOMAIN THTM_ECOLI The N-terminal region is the non-catalytic domain; the C- terminus contains the active-site cysteine residue and the CGSGVTA motif probably responsible for substrate specificity. # EcoGene EG11600 sseA # FUNCTION THTM_ECOLI Transfers a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity (130-fold lower). Its participation in detoxification of cyanide may be small. May be involved in the enhancement of serine sensitivity. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004792 thiosulfate sulfurtransferase activity; IDA:EcoCyc. # GO_function GO:0016784 3-mercaptopyruvate sulfurtransferase activity; IDA:EcoCyc. # GO_process GO:0046677 response to antibiotic; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0008150 biological_process # Gene3D 3.40.250.10 -; 2. # InterPro IPR001307 Thiosulphate_STrfase_CS # InterPro IPR001763 Rhodanese-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00270 Cysteine and methionine metabolism # KEGG_Pathway ko04122 Sulfur relay system # Organism THTM_ECOLI Escherichia coli (strain K12) # PATRIC 32120435 VBIEscCol129921_2620 # PDB 1URH X-ray; 2.80 A; A/B=2-281 # PIR H65028 H65028 # PROSITE PS00380 RHODANESE_1 # PROSITE PS00683 RHODANESE_2 # PROSITE PS50206 RHODANESE_3; 2 # Pfam PF00581 Rhodanese; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName THTM_ECOLI 3-mercaptopyruvate sulfurtransferase # RefSeq NP_417016 NC_000913.3 # RefSeq WP_000108626 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA01382.1; Type=Frameshift; Positions=59; Evidence={ECO 0000305}; # SIMILARITY Contains 2 rhodanese domains. {ECO:0000255|PROSITE- ProRule PRU00173}. # SMART SM00450 RHOD; 2 # SUBCELLULAR LOCATION THTM_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Monomer. {ECO:0000269|PubMed 14672665}. # SUPFAM SSF52821 SSF52821; 2 # eggNOG COG2897 LUCA # eggNOG ENOG4105KHC Bacteria BLAST swissprot:THTM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:THTM_ECOLI BioCyc ECOL316407:JW2505-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2505-MONOMER BioCyc EcoCyc:EG11600-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11600-MONOMER BioCyc MetaCyc:EG11600-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11600-MONOMER COG COG2897 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2897 DIP DIP-10921N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10921N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1016/S0014-5793(01)02610-2 http://dx.doi.org/10.1016/S0014-5793(01)02610-2 DOI 10.1016/j.jmb.2003.10.072 http://dx.doi.org/10.1016/j.jmb.2003.10.072 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.8.1.2 http://www.genome.jp/dbget-bin/www_bget?EC:2.8.1.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D10496 http://www.ebi.ac.uk/ena/data/view/D10496 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.8.1.2 http://enzyme.expasy.org/EC/2.8.1.2 EchoBASE EB1557 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1557 EcoGene EG11600 http://www.ecogene.org/geneInfo.php?eg_id=EG11600 EnsemblBacteria AAC75574 http://www.ensemblgenomes.org/id/AAC75574 EnsemblBacteria AAC75574 http://www.ensemblgenomes.org/id/AAC75574 EnsemblBacteria BAA16411 http://www.ensemblgenomes.org/id/BAA16411 EnsemblBacteria BAA16411 http://www.ensemblgenomes.org/id/BAA16411 EnsemblBacteria BAA16411 http://www.ensemblgenomes.org/id/BAA16411 EnsemblBacteria b2521 http://www.ensemblgenomes.org/id/b2521 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004792 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004792 GO_function GO:0016784 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016784 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.250.10 http://www.cathdb.info/version/latest/superfamily/3.40.250.10 GeneID 946993 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946993 HOGENOM HOG000157237 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000157237&db=HOGENOM6 InParanoid P31142 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31142 IntAct P31142 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31142* IntEnz 2.8.1.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.8.1.2 InterPro IPR001307 http://www.ebi.ac.uk/interpro/entry/IPR001307 InterPro IPR001763 http://www.ebi.ac.uk/interpro/entry/IPR001763 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2505 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2505 KEGG_Gene eco:b2521 http://www.genome.jp/dbget-bin/www_bget?eco:b2521 KEGG_Orthology KO:K01011 http://www.genome.jp/dbget-bin/www_bget?KO:K01011 KEGG_Pathway ko00270 http://www.genome.jp/kegg-bin/show_pathway?ko00270 KEGG_Pathway ko04122 http://www.genome.jp/kegg-bin/show_pathway?ko04122 KEGG_Reaction rn:R01931 http://www.genome.jp/dbget-bin/www_bget?rn:R01931 KEGG_Reaction rn:R03105 http://www.genome.jp/dbget-bin/www_bget?rn:R03105 KEGG_Reaction rn:R03106 http://www.genome.jp/dbget-bin/www_bget?rn:R03106 MINT MINT-1289054 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1289054 OMA SWGEWGS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SWGEWGS PDB 1URH http://www.ebi.ac.uk/pdbe-srv/view/entry/1URH PDBsum 1URH http://www.ebi.ac.uk/pdbsum/1URH PROSITE PS00380 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00380 PROSITE PS00683 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00683 PROSITE PS50206 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50206 PSORT swissprot:THTM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:THTM_ECOLI PSORT-B swissprot:THTM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:THTM_ECOLI PSORT2 swissprot:THTM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:THTM_ECOLI Pfam PF00581 http://pfam.xfam.org/family/PF00581 Phobius swissprot:THTM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:THTM_ECOLI PhylomeDB P31142 http://phylomedb.org/?seqid=P31142 ProteinModelPortal P31142 http://www.proteinmodelportal.org/query/uniprot/P31142 PubMed 11445076 http://www.ncbi.nlm.nih.gov/pubmed/11445076 PubMed 14672665 http://www.ncbi.nlm.nih.gov/pubmed/14672665 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7982894 http://www.ncbi.nlm.nih.gov/pubmed/7982894 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_417016 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417016 RefSeq WP_000108626 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000108626 SMART SM00450 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00450 SMR P31142 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31142 STRING 511145.b2521 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2521&targetmode=cogs STRING COG2897 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2897&targetmode=cogs SUPFAM SSF52821 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52821 UniProtKB THTM_ECOLI http://www.uniprot.org/uniprot/THTM_ECOLI UniProtKB-AC P31142 http://www.uniprot.org/uniprot/P31142 charge swissprot:THTM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:THTM_ECOLI eggNOG COG2897 http://eggnogapi.embl.de/nog_data/html/tree/COG2897 eggNOG ENOG4105KHC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KHC epestfind swissprot:THTM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:THTM_ECOLI garnier swissprot:THTM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:THTM_ECOLI helixturnhelix swissprot:THTM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:THTM_ECOLI hmoment swissprot:THTM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:THTM_ECOLI iep swissprot:THTM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:THTM_ECOLI inforesidue swissprot:THTM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:THTM_ECOLI octanol swissprot:THTM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:THTM_ECOLI pepcoil swissprot:THTM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:THTM_ECOLI pepdigest swissprot:THTM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:THTM_ECOLI pepinfo swissprot:THTM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:THTM_ECOLI pepnet swissprot:THTM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:THTM_ECOLI pepstats swissprot:THTM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:THTM_ECOLI pepwheel swissprot:THTM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:THTM_ECOLI pepwindow swissprot:THTM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:THTM_ECOLI sigcleave swissprot:THTM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:THTM_ECOLI ## Database ID URL or Descriptions # AltName ATMA_ECOLI Mg(2+) transport ATPase, P-type 1 # BioGrid 4261853 9 # CATALYTIC ACTIVITY ATMA_ECOLI ATP + H(2)O + Mg(2+)(Out) = ADP + phosphate + Mg(2+)(In). # EcoGene EG12525 mgtA # FUNCTION ATMA_ECOLI Mediates magnesium influx to the cytosol. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_component GO:0043231 intracellular membrane-bounded organelle; IBA:GO_Central. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0015444 magnesium-importing ATPase activity; IEA:UniProtKB-EC. # GO_function GO:0019829 cation-transporting ATPase activity; IBA:GO_Central. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0015693 magnesium ion transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043226 organelle # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # Gene3D 1.20.1110.10 -; 2. # Gene3D 2.70.150.10 -; 2. # Gene3D 3.40.1110.10 -; 1. # INDUCTION Induced by low levels of proline and by osmotic shock. The leader of mgtA mRNA functions as a riboswitch, favoring transcription under low Mg(2+) conditions. Under limiting proline levels the MgtL peptide encoded within the mgtA leader cannot be translated, thereby favoring the transcription of the mgtA ORF. Induction by osmotic shock also depends on translational regulation by MgtL (Probable). Induced by low extracellular levels of Mg(2+) via the PhoQ/PhoP two-component regulatory system. {ECO:0000269|PubMed 12813061, ECO:0000305}. # IntAct P0ABB8 2 # InterPro IPR001757 P_typ_ATPase # InterPro IPR004014 ATPase_P-typ_cation-transptr_N # InterPro IPR006068 ATPase_P-typ_cation-transptr_C # InterPro IPR006415 P-type_ATPase_IIIB # InterPro IPR008250 ATPase_P-typ_transduc_dom_A # InterPro IPR018303 ATPase_P-typ_P_site # InterPro IPR023214 HAD-like_dom # InterPro IPR023298 ATPase_P-typ_TM_dom # InterPro IPR023299 ATPase_P-typ_cyto_domN # KEGG_Brite ko01000 Enzymes # Organism ATMA_ECOLI Escherichia coli (strain K12) # PATRIC 32124059 VBIEscCol129921_4374 # PDB 3GWI X-ray; 1.60 A; A=383-545 # PIR E65236 E65236 # PRINTS PR01836 MGATPASE # PROSITE PS00154 ATPASE_E1_E2 # Pfam PF00122 E1-E2_ATPase # Pfam PF00689 Cation_ATPase_C # Pfam PF00690 Cation_ATPase_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ATMA_ECOLI Magnesium-transporting ATPase, P-type 1 # RefSeq NP_418663 NC_000913.3 # RefSeq WP_000471889 NZ_LN832404.1 # SIMILARITY Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily. {ECO 0000305}. # SMART SM00831 Cation_ATPase_N # SUBCELLULAR LOCATION ATMA_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # SUPFAM SSF56784 SSF56784 # SUPFAM SSF81660 SSF81660 # TIGRFAMs TIGR01494 ATPase_P-type; 2 # TIGRFAMs TIGR01524 ATPase-IIIB_Mg # eggNOG COG0474 LUCA # eggNOG ENOG4105C52 Bacteria BLAST swissprot:ATMA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ATMA_ECOLI BioCyc ECOL316407:JW4201-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4201-MONOMER BioCyc EcoCyc:MGTA-MONOMER http://biocyc.org/getid?id=EcoCyc:MGTA-MONOMER COG COG0474 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0474 DIP DIP-48092N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48092N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1107/S090744490903306X http://dx.doi.org/10.1107/S090744490903306X DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.185.13.3696-3702.2003 http://dx.doi.org/10.1128/JB.185.13.3696-3702.2003 EC_number EC:3.6.3.2 http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 3.6.3.2 http://enzyme.expasy.org/EC/3.6.3.2 EchoBASE EB2416 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2416 EcoGene EG12525 http://www.ecogene.org/geneInfo.php?eg_id=EG12525 EnsemblBacteria AAC77199 http://www.ensemblgenomes.org/id/AAC77199 EnsemblBacteria AAC77199 http://www.ensemblgenomes.org/id/AAC77199 EnsemblBacteria BAE78241 http://www.ensemblgenomes.org/id/BAE78241 EnsemblBacteria BAE78241 http://www.ensemblgenomes.org/id/BAE78241 EnsemblBacteria BAE78241 http://www.ensemblgenomes.org/id/BAE78241 EnsemblBacteria b4242 http://www.ensemblgenomes.org/id/b4242 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0043231 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0015444 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015444 GO_function GO:0019829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019829 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0015693 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015693 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 1.20.1110.10 http://www.cathdb.info/version/latest/superfamily/1.20.1110.10 Gene3D 2.70.150.10 http://www.cathdb.info/version/latest/superfamily/2.70.150.10 Gene3D 3.40.1110.10 http://www.cathdb.info/version/latest/superfamily/3.40.1110.10 GeneID 948778 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948778 HOGENOM HOG000265624 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000265624&db=HOGENOM6 InParanoid P0ABB8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABB8 IntAct P0ABB8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABB8* IntEnz 3.6.3.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.2 InterPro IPR001757 http://www.ebi.ac.uk/interpro/entry/IPR001757 InterPro IPR004014 http://www.ebi.ac.uk/interpro/entry/IPR004014 InterPro IPR006068 http://www.ebi.ac.uk/interpro/entry/IPR006068 InterPro IPR006415 http://www.ebi.ac.uk/interpro/entry/IPR006415 InterPro IPR008250 http://www.ebi.ac.uk/interpro/entry/IPR008250 InterPro IPR018303 http://www.ebi.ac.uk/interpro/entry/IPR018303 InterPro IPR023214 http://www.ebi.ac.uk/interpro/entry/IPR023214 InterPro IPR023298 http://www.ebi.ac.uk/interpro/entry/IPR023298 InterPro IPR023299 http://www.ebi.ac.uk/interpro/entry/IPR023299 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4201 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4201 KEGG_Gene eco:b4242 http://www.genome.jp/dbget-bin/www_bget?eco:b4242 KEGG_Orthology KO:K01531 http://www.genome.jp/dbget-bin/www_bget?KO:K01531 MINT MINT-1285807 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1285807 OMA PFDFQRR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PFDFQRR PDB 3GWI http://www.ebi.ac.uk/pdbe-srv/view/entry/3GWI PDBsum 3GWI http://www.ebi.ac.uk/pdbsum/3GWI PRINTS PR01836 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01836 PROSITE PS00154 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00154 PSORT swissprot:ATMA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ATMA_ECOLI PSORT-B swissprot:ATMA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ATMA_ECOLI PSORT2 swissprot:ATMA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ATMA_ECOLI Pfam PF00122 http://pfam.xfam.org/family/PF00122 Pfam PF00689 http://pfam.xfam.org/family/PF00689 Pfam PF00690 http://pfam.xfam.org/family/PF00690 Phobius swissprot:ATMA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ATMA_ECOLI PhylomeDB P0ABB8 http://phylomedb.org/?seqid=P0ABB8 ProteinModelPortal P0ABB8 http://www.proteinmodelportal.org/query/uniprot/P0ABB8 PubMed 12813061 http://www.ncbi.nlm.nih.gov/pubmed/12813061 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19923713 http://www.ncbi.nlm.nih.gov/pubmed/19923713 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418663 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418663 RefSeq WP_000471889 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000471889 SMART SM00831 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00831 SMR P0ABB8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABB8 STRING 511145.b4242 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4242&targetmode=cogs STRING COG0474 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0474&targetmode=cogs SUPFAM SSF56784 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784 SUPFAM SSF81660 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81660 TIGRFAMs TIGR01494 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01494 TIGRFAMs TIGR01524 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01524 UniProtKB ATMA_ECOLI http://www.uniprot.org/uniprot/ATMA_ECOLI UniProtKB-AC P0ABB8 http://www.uniprot.org/uniprot/P0ABB8 charge swissprot:ATMA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ATMA_ECOLI eggNOG COG0474 http://eggnogapi.embl.de/nog_data/html/tree/COG0474 eggNOG ENOG4105C52 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C52 epestfind swissprot:ATMA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ATMA_ECOLI garnier swissprot:ATMA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ATMA_ECOLI helixturnhelix swissprot:ATMA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ATMA_ECOLI hmoment swissprot:ATMA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ATMA_ECOLI iep swissprot:ATMA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ATMA_ECOLI inforesidue swissprot:ATMA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ATMA_ECOLI octanol swissprot:ATMA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ATMA_ECOLI pepcoil swissprot:ATMA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ATMA_ECOLI pepdigest swissprot:ATMA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ATMA_ECOLI pepinfo swissprot:ATMA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ATMA_ECOLI pepnet swissprot:ATMA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ATMA_ECOLI pepstats swissprot:ATMA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ATMA_ECOLI pepwheel swissprot:ATMA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ATMA_ECOLI pepwindow swissprot:ATMA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ATMA_ECOLI sigcleave swissprot:ATMA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ATMA_ECOLI ## Database ID URL or Descriptions # BRENDA 3.4.23.B20 2026 # BioGrid 4262374 10 # COFACTOR Name=Ni(2+); Xref=ChEBI:CHEBI 49786; # EcoGene EG11802 hybD # FUNCTION HYBD_ECOLI Protease involved in the C-terminal processing of HybC, the large subunit of hydrogenase 2. Specifically cleaves off a 15 amino acid peptide from the C-terminus of the precursor of HybC. # GO_function GO:0004175 endopeptidase activity; IBA:GO_Central. # GO_function GO:0004190 aspartic-type endopeptidase activity; IEA:UniProtKB-KW. # GO_function GO:0008047 enzyme activator activity; IEA:InterPro. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006464 cellular protein modification process; IBA:GO_Central. # GO_process GO:0016485 protein processing; ISS:EcoCyc. # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0030234 enzyme regulator activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0051604 protein maturation # Gene3D 3.40.50.1450 -; 1. # IntAct P37182 6 # InterPro IPR000671 Peptidase_A31 # InterPro IPR004419 Pept_A31_hyd_express # InterPro IPR023430 Pept_HybD-like_dom # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # Organism HYBD_ECOLI Escherichia coli (strain K12) # PATRIC 32121402 VBIEscCol129921_3088 # PDB 1CFZ X-ray; 2.20 A; A/B/C/D/E/F=1-159 # PIR G65085 G65085 # PRINTS PR00446 HYDRGNUPTAKE # Pfam PF01750 HycI # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HYBD_ECOLI Hydrogenase 2 maturation protease # RefSeq NP_417467 NC_000913.3 # RefSeq WP_001221939 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase A31 family. {ECO 0000305}. # SUPFAM SSF53163 SSF53163 # TIGRFAMs TIGR00072 hydrog_prot # TIGRFAMs TIGR00140 hupD # eggNOG COG0680 LUCA # eggNOG ENOG4108USZ Bacteria BLAST swissprot:HYBD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HYBD_ECOLI BioCyc ECOL316407:JW2961-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2961-MONOMER BioCyc EcoCyc:EG11802-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11802-MONOMER COG COG0680 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0680 DIP DIP-9967N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9967N DOI 10.1006/jmbi.1999.2719 http://dx.doi.org/10.1006/jmbi.1999.2719 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.23.- http://www.genome.jp/dbget-bin/www_bget?EC:3.4.23.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U09177 http://www.ebi.ac.uk/ena/data/view/U09177 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 ENZYME 3.4.23.- http://enzyme.expasy.org/EC/3.4.23.- EchoBASE EB1750 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1750 EcoGene EG11802 http://www.ecogene.org/geneInfo.php?eg_id=EG11802 EnsemblBacteria AAC76029 http://www.ensemblgenomes.org/id/AAC76029 EnsemblBacteria AAC76029 http://www.ensemblgenomes.org/id/AAC76029 EnsemblBacteria BAE77054 http://www.ensemblgenomes.org/id/BAE77054 EnsemblBacteria BAE77054 http://www.ensemblgenomes.org/id/BAE77054 EnsemblBacteria BAE77054 http://www.ensemblgenomes.org/id/BAE77054 EnsemblBacteria b2993 http://www.ensemblgenomes.org/id/b2993 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004175 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004175 GO_function GO:0004190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004190 GO_function GO:0008047 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008047 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GO_process GO:0016485 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016485 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 Gene3D 3.40.50.1450 http://www.cathdb.info/version/latest/superfamily/3.40.50.1450 GeneID 948982 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948982 HOGENOM HOG000278719 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278719&db=HOGENOM6 InParanoid P37182 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37182 IntAct P37182 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37182* IntEnz 3.4.23 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.23 InterPro IPR000671 http://www.ebi.ac.uk/interpro/entry/IPR000671 InterPro IPR004419 http://www.ebi.ac.uk/interpro/entry/IPR004419 InterPro IPR023430 http://www.ebi.ac.uk/interpro/entry/IPR023430 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW2961 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2961 KEGG_Gene eco:b2993 http://www.genome.jp/dbget-bin/www_bget?eco:b2993 KEGG_Orthology KO:K08567 http://www.genome.jp/dbget-bin/www_bget?KO:K08567 OMA PHQLGLC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PHQLGLC PDB 1CFZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1CFZ PDBsum 1CFZ http://www.ebi.ac.uk/pdbsum/1CFZ PRINTS PR00446 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00446 PSORT swissprot:HYBD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HYBD_ECOLI PSORT-B swissprot:HYBD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HYBD_ECOLI PSORT2 swissprot:HYBD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HYBD_ECOLI Pfam PF01750 http://pfam.xfam.org/family/PF01750 Phobius swissprot:HYBD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HYBD_ECOLI PhylomeDB P37182 http://phylomedb.org/?seqid=P37182 ProteinModelPortal P37182 http://www.proteinmodelportal.org/query/uniprot/P37182 PubMed 10331925 http://www.ncbi.nlm.nih.gov/pubmed/10331925 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8021226 http://www.ncbi.nlm.nih.gov/pubmed/8021226 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417467 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417467 RefSeq WP_001221939 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001221939 SMR P37182 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37182 STRING 511145.b2993 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2993&targetmode=cogs STRING COG0680 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0680&targetmode=cogs SUPFAM SSF53163 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53163 TIGRFAMs TIGR00072 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00072 TIGRFAMs TIGR00140 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00140 UniProtKB HYBD_ECOLI http://www.uniprot.org/uniprot/HYBD_ECOLI UniProtKB-AC P37182 http://www.uniprot.org/uniprot/P37182 charge swissprot:HYBD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HYBD_ECOLI eggNOG COG0680 http://eggnogapi.embl.de/nog_data/html/tree/COG0680 eggNOG ENOG4108USZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108USZ epestfind swissprot:HYBD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HYBD_ECOLI garnier swissprot:HYBD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HYBD_ECOLI helixturnhelix swissprot:HYBD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HYBD_ECOLI hmoment swissprot:HYBD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HYBD_ECOLI iep swissprot:HYBD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HYBD_ECOLI inforesidue swissprot:HYBD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HYBD_ECOLI octanol swissprot:HYBD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HYBD_ECOLI pepcoil swissprot:HYBD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HYBD_ECOLI pepdigest swissprot:HYBD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HYBD_ECOLI pepinfo swissprot:HYBD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HYBD_ECOLI pepnet swissprot:HYBD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HYBD_ECOLI pepstats swissprot:HYBD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HYBD_ECOLI pepwheel swissprot:HYBD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HYBD_ECOLI pepwindow swissprot:HYBD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HYBD_ECOLI sigcleave swissprot:HYBD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HYBD_ECOLI ## Database ID URL or Descriptions # AltName Gamma-glutamyl kinase {ECO:0000255|HAMAP-Rule MF_00456} # BIOPHYSICOCHEMICAL PROPERTIES pH dependence: Optimum pH is 6.5-7.0. {ECO 0000269|PubMed:6319365}; # BRENDA 2.7.2.11 2026 # BioGrid 4259767 2 # CATALYTIC ACTIVITY PROB_ECOLI ATP + L-glutamate = ADP + L-glutamate 5- phosphate. {ECO 0000255|HAMAP-Rule MF_00456, ECO 0000269|PubMed 6319365}. # DOMAIN PROB_ECOLI Contains an N-terminal amino acid kinase (AAK) domain and a C-terminal PUA domain. The AAK domain is responsible for catalyzing the reaction and for proline and ADP inhibition. The PUA domain modulates the catalytic and regulatory functions of the AAK domain. {ECO 0000269|PubMed 16337196}. # ENZYME REGULATION PROB_ECOLI Interaction with gamma-glutamyl phosphate reductase (proA) seems necessary for kinase activity. Requires free Mg(2+). Inhibited by proline and ADP. {ECO 0000269|PubMed 16337196, ECO 0000269|PubMed 6319365}. # EcoGene EG10768 proB # FUNCTION PROB_ECOLI Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. {ECO 0000255|HAMAP-Rule MF_00456, ECO 0000269|PubMed 6319365}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0003723 RNA binding; IEA:InterPro. # GO_function GO:0004349 glutamate 5-kinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0006561 proline biosynthetic process; IMP:EcoCyc. # GO_process GO:0055129 L-proline biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 2.30.130.10 -; 1. # Gene3D 3.40.1160.10 -; 1. # HAMAP MF_00456 ProB # IntAct P0A7B5 2 # InterPro IPR001048 Asp/Glu/Uridylate_kinase # InterPro IPR001057 Glu/AcGlu_kinase # InterPro IPR002478 PUA # InterPro IPR005715 Glu_5kinase/COase_Synthase # InterPro IPR011529 Glu_5kinase # InterPro IPR015947 PUA-like_domain # InterPro IPR019797 Glutamate_5-kinase_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00330 Arginine and proline metabolism # Organism PROB_ECOLI Escherichia coli (strain K12) # PATHWAY PROB_ECOLI Amino-acid biosynthesis; L-proline biosynthesis; L- glutamate 5-semialdehyde from L-glutamate step 1/2. {ECO 0000255|HAMAP-Rule MF_00456, ECO 0000269|PubMed 6319365}. # PATRIC 32115599 VBIEscCol129921_0244 # PDB 2J5T X-ray; 2.90 A; A/B/C/D/E/F/G/H=1-367 # PDB 2J5V X-ray; 2.50 A; A/B=1-367 # PDB 2W21 X-ray; 2.95 A; A=1-259 # PIR C64749 KIECEG # PIRSF PIRSF000729 GK # PRINTS PR00474 GLU5KINASE # PROSITE PS00902 GLUTAMATE_5_KINASE # PROSITE PS50890 PUA # Pfam PF00696 AA_kinase # Pfam PF01472 PUA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Glutamate 5-kinase {ECO:0000255|HAMAP-Rule MF_00456} # RefSeq NP_414777 NC_000913.3 # RefSeq WP_001285288 NZ_LN832404.1 # SIMILARITY Belongs to the glutamate 5-kinase family. {ECO:0000255|HAMAP-Rule MF_00456}. # SIMILARITY Contains 1 PUA domain. {ECO:0000255|HAMAP- Rule MF_00456}. # SMART SM00359 PUA # SUBCELLULAR LOCATION PROB_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00456}. # SUBUNIT PROB_ECOLI Homotetramer. Dimer of dimers. May form a complex with gamma-glutamyl phosphate reductase (proA). {ECO 0000269|PubMed 16337196, ECO 0000269|PubMed 17321544, ECO 0000269|PubMed 6319365}. # SUPFAM SSF53633 SSF53633 # SUPFAM SSF88697 SSF88697 # TIGRFAMs TIGR01027 proB # UniPathway UPA00098 UER00359 # eggNOG COG0263 LUCA # eggNOG ENOG4105CGT Bacteria BLAST swissprot:PROB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PROB_ECOLI BioCyc ECOL316407:JW0232-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0232-MONOMER BioCyc EcoCyc:GLUTKIN-MONOMER http://biocyc.org/getid?id=EcoCyc:GLUTKIN-MONOMER BioCyc MetaCyc:GLUTKIN-MONOMER http://biocyc.org/getid?id=MetaCyc:GLUTKIN-MONOMER COG COG0263 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0263 DOI 10.1016/0022-2836(83)90110-9 http://dx.doi.org/10.1016/0022-2836(83)90110-9 DOI 10.1016/j.febslet.2005.11.037 http://dx.doi.org/10.1016/j.febslet.2005.11.037 DOI 10.1016/j.jmb.2007.01.073 http://dx.doi.org/10.1016/j.jmb.2007.01.073 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/12.15.6337 http://dx.doi.org/10.1093/nar/12.15.6337 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.2.11 {ECO:0000255|HAMAP-Rule:MF_00456} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.2.11 {ECO:0000255|HAMAP-Rule:MF_00456} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EMBL V00316 http://www.ebi.ac.uk/ena/data/view/V00316 EMBL X00786 http://www.ebi.ac.uk/ena/data/view/X00786 ENZYME 2.7.2.11 {ECO:0000255|HAMAP-Rule:MF_00456} http://enzyme.expasy.org/EC/2.7.2.11 {ECO:0000255|HAMAP-Rule:MF_00456} EchoBASE EB0761 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0761 EcoGene EG10768 http://www.ecogene.org/geneInfo.php?eg_id=EG10768 EnsemblBacteria AAC73346 http://www.ensemblgenomes.org/id/AAC73346 EnsemblBacteria AAC73346 http://www.ensemblgenomes.org/id/AAC73346 EnsemblBacteria BAA77911 http://www.ensemblgenomes.org/id/BAA77911 EnsemblBacteria BAA77911 http://www.ensemblgenomes.org/id/BAA77911 EnsemblBacteria BAA77911 http://www.ensemblgenomes.org/id/BAA77911 EnsemblBacteria b0242 http://www.ensemblgenomes.org/id/b0242 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0004349 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004349 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006561 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006561 GO_process GO:0055129 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055129 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 2.30.130.10 http://www.cathdb.info/version/latest/superfamily/2.30.130.10 Gene3D 3.40.1160.10 http://www.cathdb.info/version/latest/superfamily/3.40.1160.10 GeneID 946425 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946425 HAMAP MF_00456 http://hamap.expasy.org/unirule/MF_00456 HOGENOM HOG000246369 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000246369&db=HOGENOM6 InParanoid P0A7B5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7B5 IntAct P0A7B5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7B5* IntEnz 2.7.2.11 {ECO:0000255|HAMAP-Rule:MF_00456} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.2.11 {ECO:0000255|HAMAP-Rule:MF_00456} InterPro IPR001048 http://www.ebi.ac.uk/interpro/entry/IPR001048 InterPro IPR001057 http://www.ebi.ac.uk/interpro/entry/IPR001057 InterPro IPR002478 http://www.ebi.ac.uk/interpro/entry/IPR002478 InterPro IPR005715 http://www.ebi.ac.uk/interpro/entry/IPR005715 InterPro IPR011529 http://www.ebi.ac.uk/interpro/entry/IPR011529 InterPro IPR015947 http://www.ebi.ac.uk/interpro/entry/IPR015947 InterPro IPR019797 http://www.ebi.ac.uk/interpro/entry/IPR019797 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0232 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0232 KEGG_Gene eco:b0242 http://www.genome.jp/dbget-bin/www_bget?eco:b0242 KEGG_Orthology KO:K00931 http://www.genome.jp/dbget-bin/www_bget?KO:K00931 KEGG_Pathway ko00330 http://www.genome.jp/kegg-bin/show_pathway?ko00330 KEGG_Reaction rn:R00239 http://www.genome.jp/dbget-bin/www_bget?rn:R00239 OMA VIHRDHW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VIHRDHW PDB 2J5T http://www.ebi.ac.uk/pdbe-srv/view/entry/2J5T PDB 2J5V http://www.ebi.ac.uk/pdbe-srv/view/entry/2J5V PDB 2W21 http://www.ebi.ac.uk/pdbe-srv/view/entry/2W21 PDBsum 2J5T http://www.ebi.ac.uk/pdbsum/2J5T PDBsum 2J5V http://www.ebi.ac.uk/pdbsum/2J5V PDBsum 2W21 http://www.ebi.ac.uk/pdbsum/2W21 PRINTS PR00474 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00474 PROSITE PS00902 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00902 PROSITE PS50890 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50890 PSORT swissprot:PROB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PROB_ECOLI PSORT-B swissprot:PROB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PROB_ECOLI PSORT2 swissprot:PROB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PROB_ECOLI Pfam PF00696 http://pfam.xfam.org/family/PF00696 Pfam PF01472 http://pfam.xfam.org/family/PF01472 Phobius swissprot:PROB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PROB_ECOLI PhylomeDB P0A7B5 http://phylomedb.org/?seqid=P0A7B5 ProteinModelPortal P0A7B5 http://www.proteinmodelportal.org/query/uniprot/P0A7B5 PubMed 16337196 http://www.ncbi.nlm.nih.gov/pubmed/16337196 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17321544 http://www.ncbi.nlm.nih.gov/pubmed/17321544 PubMed 6089111 http://www.ncbi.nlm.nih.gov/pubmed/6089111 PubMed 6319365 http://www.ncbi.nlm.nih.gov/pubmed/6319365 PubMed 6341601 http://www.ncbi.nlm.nih.gov/pubmed/6341601 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414777 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414777 RefSeq WP_001285288 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001285288 SMART SM00359 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00359 SMR P0A7B5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7B5 STRING 511145.b0242 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0242&targetmode=cogs STRING COG0263 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0263&targetmode=cogs SUPFAM SSF53633 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53633 SUPFAM SSF88697 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF88697 TIGRFAMs TIGR01027 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01027 UniProtKB PROB_ECOLI http://www.uniprot.org/uniprot/PROB_ECOLI UniProtKB-AC P0A7B5 http://www.uniprot.org/uniprot/P0A7B5 charge swissprot:PROB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PROB_ECOLI eggNOG COG0263 http://eggnogapi.embl.de/nog_data/html/tree/COG0263 eggNOG ENOG4105CGT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CGT epestfind swissprot:PROB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PROB_ECOLI garnier swissprot:PROB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PROB_ECOLI helixturnhelix swissprot:PROB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PROB_ECOLI hmoment swissprot:PROB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PROB_ECOLI iep swissprot:PROB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PROB_ECOLI inforesidue swissprot:PROB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PROB_ECOLI octanol swissprot:PROB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PROB_ECOLI pepcoil swissprot:PROB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PROB_ECOLI pepdigest swissprot:PROB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PROB_ECOLI pepinfo swissprot:PROB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PROB_ECOLI pepnet swissprot:PROB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PROB_ECOLI pepstats swissprot:PROB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PROB_ECOLI pepwheel swissprot:PROB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PROB_ECOLI pepwindow swissprot:PROB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PROB_ECOLI sigcleave swissprot:PROB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PROB_ECOLI ## Database ID URL or Descriptions # AltName DSDC_ECOLI D-serine deaminase activator # BioGrid 4260553 4 # EcoGene EG13161 dsdC # FUNCTION DSDC_ECOLI Regulates the expression of the dsd operon for D-serine deaminase (dsdA). {ECO 0000269|PubMed 7592420}. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0043565 sequence-specific DNA binding; IBA:GO_Central. # GO_process GO:0006351 transcription, DNA-templated; IBA:GO_Central. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # IntAct P46068 5 # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR005119 LysR_subst-bd # InterPro IPR011781 DsdC # InterPro IPR011991 WHTH_DNA-bd_dom # KEGG_Brite ko03000 Transcription factors # Organism DSDC_ECOLI Escherichia coli (strain K12) # PATRIC 32120107 VBIEscCol129921_2462 # PIR A65010 A65010 # PRINTS PR00039 HTHLYSR # PROSITE PS50931 HTH_LYSR # Pfam PF00126 HTH_1 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DSDC_ECOLI HTH-type transcriptional regulator DsdC # RefSeq NP_416865 NC_000913.3 # RefSeq WP_001326971 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lysR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00253}. # SUPFAM SSF46785 SSF46785 # TIGRFAMs TIGR02036 dsdC # eggNOG COG0583 LUCA # eggNOG ENOG4105W8I Bacteria BLAST swissprot:DSDC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DSDC_ECOLI BioCyc ECOL316407:JW2361-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2361-MONOMER BioCyc EcoCyc:PD00297 http://biocyc.org/getid?id=EcoCyc:PD00297 COG COG0583 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0583 DIP DIP-9480N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9480N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X86379 http://www.ebi.ac.uk/ena/data/view/X86379 EMBL X91821 http://www.ebi.ac.uk/ena/data/view/X91821 EchoBASE EB2953 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2953 EcoGene EG13161 http://www.ecogene.org/geneInfo.php?eg_id=EG13161 EnsemblBacteria AAC75423 http://www.ensemblgenomes.org/id/AAC75423 EnsemblBacteria AAC75423 http://www.ensemblgenomes.org/id/AAC75423 EnsemblBacteria BAA16224 http://www.ensemblgenomes.org/id/BAA16224 EnsemblBacteria BAA16224 http://www.ensemblgenomes.org/id/BAA16224 EnsemblBacteria BAA16224 http://www.ensemblgenomes.org/id/BAA16224 EnsemblBacteria b2364 http://www.ensemblgenomes.org/id/b2364 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 948828 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948828 HOGENOM HOG000233528 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000233528&db=HOGENOM6 InParanoid P46068 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P46068 IntAct P46068 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P46068* InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 InterPro IPR011781 http://www.ebi.ac.uk/interpro/entry/IPR011781 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW2361 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2361 KEGG_Gene eco:b2364 http://www.genome.jp/dbget-bin/www_bget?eco:b2364 KEGG_Orthology KO:K13636 http://www.genome.jp/dbget-bin/www_bget?KO:K13636 OMA NHVGVAM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NHVGVAM PRINTS PR00039 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00039 PROSITE PS50931 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50931 PSORT swissprot:DSDC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DSDC_ECOLI PSORT-B swissprot:DSDC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DSDC_ECOLI PSORT2 swissprot:DSDC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DSDC_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:DSDC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DSDC_ECOLI PhylomeDB P46068 http://phylomedb.org/?seqid=P46068 ProteinModelPortal P46068 http://www.proteinmodelportal.org/query/uniprot/P46068 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7592420 http://www.ncbi.nlm.nih.gov/pubmed/7592420 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416865 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416865 RefSeq WP_001326971 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001326971 SMR P46068 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P46068 STRING 511145.b2364 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2364&targetmode=cogs STRING COG0583 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0583&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 TIGRFAMs TIGR02036 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02036 UniProtKB DSDC_ECOLI http://www.uniprot.org/uniprot/DSDC_ECOLI UniProtKB-AC P46068 http://www.uniprot.org/uniprot/P46068 charge swissprot:DSDC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DSDC_ECOLI eggNOG COG0583 http://eggnogapi.embl.de/nog_data/html/tree/COG0583 eggNOG ENOG4105W8I http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105W8I epestfind swissprot:DSDC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DSDC_ECOLI garnier swissprot:DSDC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DSDC_ECOLI helixturnhelix swissprot:DSDC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DSDC_ECOLI hmoment swissprot:DSDC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DSDC_ECOLI iep swissprot:DSDC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DSDC_ECOLI inforesidue swissprot:DSDC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DSDC_ECOLI octanol swissprot:DSDC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DSDC_ECOLI pepcoil swissprot:DSDC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DSDC_ECOLI pepdigest swissprot:DSDC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DSDC_ECOLI pepinfo swissprot:DSDC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DSDC_ECOLI pepnet swissprot:DSDC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DSDC_ECOLI pepstats swissprot:DSDC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DSDC_ECOLI pepwheel swissprot:DSDC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DSDC_ECOLI pepwindow swissprot:DSDC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DSDC_ECOLI sigcleave swissprot:DSDC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DSDC_ECOLI ## Database ID URL or Descriptions # BioGrid 4260985 5 # EcoGene EG10167 cstA # FUNCTION CSTA_ECOLI Peptide utilization during carbon starvation. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_process GO:0009267 cellular response to starvation; IEP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006950 response to stress # INDUCTION CSTA_ECOLI By carbon starvation. # InterPro IPR003706 CstA_N # InterPro IPR025299 CstA_C # Organism CSTA_ECOLI Escherichia coli (strain K12) # PATRIC 32116372 VBIEscCol129921_0626 # PIR D64793 Q0ECNA # Pfam PF02554 CstA # Pfam PF13722 CstA_5TM # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CSTA_ECOLI Carbon starvation protein A # RefSeq NP_415130 NC_000913.3 # RefSeq WP_001043156 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA37087.1; Type=Frameshift; Positions=543; Evidence={ECO 0000305}; # SIMILARITY Belongs to the CstA family. {ECO 0000305}. # SUBCELLULAR LOCATION CSTA_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.114.1 the putative peptide transporter carbon starvation csta (csta) family # eggNOG COG1966 LUCA # eggNOG ENOG4105D22 Bacteria BLAST swissprot:CSTA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CSTA_ECOLI BioCyc ECOL316407:JW0590-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0590-MONOMER BioCyc EcoCyc:EG10167-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10167-MONOMER COG COG1966 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1966 DOI 10.1016/0022-2836(91)90879-B http://dx.doi.org/10.1016/0022-2836(91)90879-B DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M24148 http://www.ebi.ac.uk/ena/data/view/M24148 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EMBL X52904 http://www.ebi.ac.uk/ena/data/view/X52904 EMBL X52904 http://www.ebi.ac.uk/ena/data/view/X52904 EchoBASE EB0165 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0165 EcoGene EG10167 http://www.ecogene.org/geneInfo.php?eg_id=EG10167 EnsemblBacteria AAC73699 http://www.ensemblgenomes.org/id/AAC73699 EnsemblBacteria AAC73699 http://www.ensemblgenomes.org/id/AAC73699 EnsemblBacteria BAA35227 http://www.ensemblgenomes.org/id/BAA35227 EnsemblBacteria BAA35227 http://www.ensemblgenomes.org/id/BAA35227 EnsemblBacteria BAA35227 http://www.ensemblgenomes.org/id/BAA35227 EnsemblBacteria b0598 http://www.ensemblgenomes.org/id/b0598 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_process GO:0009267 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009267 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 945213 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945213 HOGENOM HOG000220271 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220271&db=HOGENOM6 InParanoid P15078 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P15078 InterPro IPR003706 http://www.ebi.ac.uk/interpro/entry/IPR003706 InterPro IPR025299 http://www.ebi.ac.uk/interpro/entry/IPR025299 KEGG_Gene ecj:JW0590 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0590 KEGG_Gene eco:b0598 http://www.genome.jp/dbget-bin/www_bget?eco:b0598 KEGG_Orthology KO:K06200 http://www.genome.jp/dbget-bin/www_bget?KO:K06200 OMA WGFSISA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WGFSISA PSORT swissprot:CSTA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CSTA_ECOLI PSORT-B swissprot:CSTA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CSTA_ECOLI PSORT2 swissprot:CSTA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CSTA_ECOLI Pfam PF02554 http://pfam.xfam.org/family/PF02554 Pfam PF13722 http://pfam.xfam.org/family/PF13722 Phobius swissprot:CSTA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CSTA_ECOLI PhylomeDB P15078 http://phylomedb.org/?seqid=P15078 ProteinModelPortal P15078 http://www.proteinmodelportal.org/query/uniprot/P15078 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1848300 http://www.ncbi.nlm.nih.gov/pubmed/1848300 PubMed 2521622 http://www.ncbi.nlm.nih.gov/pubmed/2521622 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415130 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415130 RefSeq WP_001043156 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001043156 SMR P15078 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P15078 STRING 511145.b0598 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0598&targetmode=cogs STRING COG1966 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1966&targetmode=cogs TCDB 2.A.114.1 http://www.tcdb.org/search/result.php?tc=2.A.114.1 UniProtKB CSTA_ECOLI http://www.uniprot.org/uniprot/CSTA_ECOLI UniProtKB-AC P15078 http://www.uniprot.org/uniprot/P15078 charge swissprot:CSTA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CSTA_ECOLI eggNOG COG1966 http://eggnogapi.embl.de/nog_data/html/tree/COG1966 eggNOG ENOG4105D22 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D22 epestfind swissprot:CSTA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CSTA_ECOLI garnier swissprot:CSTA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CSTA_ECOLI helixturnhelix swissprot:CSTA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CSTA_ECOLI hmoment swissprot:CSTA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CSTA_ECOLI iep swissprot:CSTA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CSTA_ECOLI inforesidue swissprot:CSTA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CSTA_ECOLI octanol swissprot:CSTA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CSTA_ECOLI pepcoil swissprot:CSTA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CSTA_ECOLI pepdigest swissprot:CSTA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CSTA_ECOLI pepinfo swissprot:CSTA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CSTA_ECOLI pepnet swissprot:CSTA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CSTA_ECOLI pepstats swissprot:CSTA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CSTA_ECOLI pepwheel swissprot:CSTA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CSTA_ECOLI pepwindow swissprot:CSTA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CSTA_ECOLI sigcleave swissprot:CSTA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CSTA_ECOLI ## Database ID URL or Descriptions # EcoGene EG12980 yggT # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # IntAct P64564 3 # InterPro IPR003425 CCB3/YggT # KEGG_Brite ko02044 Secretion system # Organism YGGT_ECOLI Escherichia coli (strain K12) # PATRIC 32121316 VBIEscCol129921_3046 # PIR G65080 G65080 # Pfam PF02325 YGGT; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGGT_ECOLI Uncharacterized protein YggT # RefSeq NP_417427 NC_000913.3 # RefSeq WP_001094831 NZ_LN832404.1 # SIMILARITY Belongs to the YggT family. {ECO 0000305}. # SUBCELLULAR LOCATION YGGT_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # eggNOG COG0762 LUCA # eggNOG ENOG4108VIA Bacteria BLAST swissprot:YGGT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGGT_ECOLI BioCyc ECOL316407:JW2919-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2919-MONOMER BioCyc EcoCyc:G7528-MONOMER http://biocyc.org/getid?id=EcoCyc:G7528-MONOMER COG COG0762 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0762 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2805 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2805 EcoGene EG12980 http://www.ecogene.org/geneInfo.php?eg_id=EG12980 EnsemblBacteria AAC75989 http://www.ensemblgenomes.org/id/AAC75989 EnsemblBacteria AAC75989 http://www.ensemblgenomes.org/id/AAC75989 EnsemblBacteria BAE77015 http://www.ensemblgenomes.org/id/BAE77015 EnsemblBacteria BAE77015 http://www.ensemblgenomes.org/id/BAE77015 EnsemblBacteria BAE77015 http://www.ensemblgenomes.org/id/BAE77015 EnsemblBacteria b2952 http://www.ensemblgenomes.org/id/b2952 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 947421 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947421 HOGENOM HOG000257384 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000257384&db=HOGENOM6 InParanoid P64564 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P64564 IntAct P64564 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P64564* InterPro IPR003425 http://www.ebi.ac.uk/interpro/entry/IPR003425 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW2919 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2919 KEGG_Gene eco:b2952 http://www.genome.jp/dbget-bin/www_bget?eco:b2952 KEGG_Orthology KO:K02221 http://www.genome.jp/dbget-bin/www_bget?KO:K02221 OMA IRSLMSW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IRSLMSW PSORT swissprot:YGGT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGGT_ECOLI PSORT-B swissprot:YGGT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGGT_ECOLI PSORT2 swissprot:YGGT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGGT_ECOLI Pfam PF02325 http://pfam.xfam.org/family/PF02325 Phobius swissprot:YGGT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGGT_ECOLI ProteinModelPortal P64564 http://www.proteinmodelportal.org/query/uniprot/P64564 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417427 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417427 RefSeq WP_001094831 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001094831 STRING 511145.b2952 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2952&targetmode=cogs STRING COG0762 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0762&targetmode=cogs UniProtKB YGGT_ECOLI http://www.uniprot.org/uniprot/YGGT_ECOLI UniProtKB-AC P64564 http://www.uniprot.org/uniprot/P64564 charge swissprot:YGGT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGGT_ECOLI eggNOG COG0762 http://eggnogapi.embl.de/nog_data/html/tree/COG0762 eggNOG ENOG4108VIA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108VIA epestfind swissprot:YGGT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGGT_ECOLI garnier swissprot:YGGT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGGT_ECOLI helixturnhelix swissprot:YGGT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGGT_ECOLI hmoment swissprot:YGGT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGGT_ECOLI iep swissprot:YGGT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGGT_ECOLI inforesidue swissprot:YGGT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGGT_ECOLI octanol swissprot:YGGT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGGT_ECOLI pepcoil swissprot:YGGT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGGT_ECOLI pepdigest swissprot:YGGT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGGT_ECOLI pepinfo swissprot:YGGT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGGT_ECOLI pepnet swissprot:YGGT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGGT_ECOLI pepstats swissprot:YGGT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGGT_ECOLI pepwheel swissprot:YGGT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGGT_ECOLI pepwindow swissprot:YGGT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGGT_ECOLI sigcleave swissprot:YGGT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGGT_ECOLI ## Database ID URL or Descriptions # AltName GLTB_ECOLI Glutamate synthase subunit alpha # AltName GLTB_ECOLI NADPH-GOGAT # BRENDA 1.4.1.13 2026 # BioGrid 4263210 332 # CATALYTIC ACTIVITY GLTB_ECOLI 2 L-glutamate + NADP(+) = L-glutamine + 2- oxoglutarate + NADPH. # CDD cd02808 GltS_FMN # COFACTOR Name=FAD; Xref=ChEBI:CHEBI 57692; # COFACTOR Name=FMN; Xref=ChEBI:CHEBI 58210; # COFACTOR Name=[3Fe-4S] cluster; Xref=ChEBI:CHEBI 21137; Note=Binds 1 [3Fe-4S] cluster.; # EcoGene EG10403 gltB # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004355 glutamate synthase (NADPH) activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051538 3 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0006537 glutamate biosynthetic process; IDA:EcoCyc. # GO_process GO:0008652 cellular amino acid biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0019676 ammonia assimilation cycle; IBA:GO_Central. # GO_process GO:0097054 L-glutamate biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 2.160.20.60 -; 1. # Gene3D 3.20.20.70 -; 2. # Gene3D 3.60.20.10 -; 1. # INTERACTION GLTB_ECOLI P09832 gltD; NbExp=2; IntAct=EBI-551179, EBI-544293; # IntAct P09831 8 # InterPro IPR002489 Glu_synth_asu_C # InterPro IPR002932 Glu_synthdom # InterPro IPR006982 Glu_synth_centr_N # InterPro IPR013785 Aldolase_TIM # InterPro IPR017932 GATase_2_dom # InterPro IPR029055 Ntn_hydrolases_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00250 Alanine, aspartate and glutamate metabolism # KEGG_Pathway ko00910 Nitrogen metabolism # MISCELLANEOUS GLTB_ECOLI Glutamine binds to the large subunit and transfers the amido group to 2-oxo-glutamate that apparently binds to the small subunit. # Organism GLTB_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-glutamate biosynthesis via GLT pathway; L-glutamate from 2-oxoglutarate and L-glutamine (NADP(+) route) step 1/1. # PATHWAY GLTB_ECOLI Energy metabolism; nitrogen metabolism. # PATRIC 32121846 VBIEscCol129921_3307 # PIR F65112 F65112 # PROSITE PS51278 GATASE_TYPE_2 # Pfam PF00310 GATase_2 # Pfam PF01493 GXGXG # Pfam PF01645 Glu_synthase # Pfam PF04898 Glu_syn_central # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLTB_ECOLI Glutamate synthase [NADPH] large chain # RefSeq NP_417679 NC_000913.3 # RefSeq WP_001300352 NZ_LN832404.1 # SEQUENCE CAUTION GLTB_ECOLI Sequence=AAA23904.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=AAA23906.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=AAA58014.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=BAE77256.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the glutamate synthase family. {ECO 0000305}. # SIMILARITY Contains 1 glutamine amidotransferase type-2 domain. {ECO:0000255|PROSITE-ProRule PRU00609}. # SUBUNIT GLTB_ECOLI Aggregate of 4 catalytic active heterodimers, consisting of a large and a small subunit. # SUPFAM SSF56235 SSF56235 # SUPFAM SSF69336 SSF69336 # UniPathway UPA00634 UER00689 # eggNOG COG0067 LUCA # eggNOG COG0069 LUCA # eggNOG COG0070 LUCA # eggNOG ENOG4105CBC Bacteria BLAST swissprot:GLTB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLTB_ECOLI BioCyc ECOL316407:JW3179-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3179-MONOMER BioCyc EcoCyc:GLUSYNLARGE-MONOMER http://biocyc.org/getid?id=EcoCyc:GLUSYNLARGE-MONOMER BioCyc MetaCyc:GLUSYNLARGE-MONOMER http://biocyc.org/getid?id=MetaCyc:GLUSYNLARGE-MONOMER COG COG0067 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0067 COG COG0069 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0069 COG COG0070 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0070 DIP DIP-9802N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9802N DOI 10.1016/0378-1119(87)90207-1 http://dx.doi.org/10.1016/0378-1119(87)90207-1 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.4.1.13 http://www.genome.jp/dbget-bin/www_bget?EC:1.4.1.13 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M18747 http://www.ebi.ac.uk/ena/data/view/M18747 EMBL M68876 http://www.ebi.ac.uk/ena/data/view/M68876 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 1.4.1.13 http://enzyme.expasy.org/EC/1.4.1.13 EchoBASE EB0398 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0398 EcoGene EG10403 http://www.ecogene.org/geneInfo.php?eg_id=EG10403 EnsemblBacteria AAC76244 http://www.ensemblgenomes.org/id/AAC76244 EnsemblBacteria AAC76244 http://www.ensemblgenomes.org/id/AAC76244 EnsemblBacteria BAE77256 http://www.ensemblgenomes.org/id/BAE77256 EnsemblBacteria BAE77256 http://www.ensemblgenomes.org/id/BAE77256 EnsemblBacteria BAE77256 http://www.ensemblgenomes.org/id/BAE77256 EnsemblBacteria b3212 http://www.ensemblgenomes.org/id/b3212 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004355 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051538 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051538 GO_process GO:0006537 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006537 GO_process GO:0008652 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008652 GO_process GO:0019676 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019676 GO_process GO:0097054 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097054 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 2.160.20.60 http://www.cathdb.info/version/latest/superfamily/2.160.20.60 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 Gene3D 3.60.20.10 http://www.cathdb.info/version/latest/superfamily/3.60.20.10 GeneID 947724 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947724 HOGENOM HOG000031558 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000031558&db=HOGENOM6 InParanoid P09831 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P09831 IntAct P09831 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P09831* IntEnz 1.4.1.13 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.4.1.13 InterPro IPR002489 http://www.ebi.ac.uk/interpro/entry/IPR002489 InterPro IPR002932 http://www.ebi.ac.uk/interpro/entry/IPR002932 InterPro IPR006982 http://www.ebi.ac.uk/interpro/entry/IPR006982 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR017932 http://www.ebi.ac.uk/interpro/entry/IPR017932 InterPro IPR029055 http://www.ebi.ac.uk/interpro/entry/IPR029055 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3179 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3179 KEGG_Gene eco:b3212 http://www.genome.jp/dbget-bin/www_bget?eco:b3212 KEGG_Orthology KO:K00265 http://www.genome.jp/dbget-bin/www_bget?KO:K00265 KEGG_Pathway ko00250 http://www.genome.jp/kegg-bin/show_pathway?ko00250 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Reaction rn:R00093 http://www.genome.jp/dbget-bin/www_bget?rn:R00093 KEGG_Reaction rn:R00114 http://www.genome.jp/dbget-bin/www_bget?rn:R00114 KEGG_Reaction rn:R00248 http://www.genome.jp/dbget-bin/www_bget?rn:R00248 MINT MINT-1248755 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1248755 PROSITE PS51278 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51278 PSORT swissprot:GLTB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLTB_ECOLI PSORT-B swissprot:GLTB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLTB_ECOLI PSORT2 swissprot:GLTB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLTB_ECOLI Pfam PF00310 http://pfam.xfam.org/family/PF00310 Pfam PF01493 http://pfam.xfam.org/family/PF01493 Pfam PF01645 http://pfam.xfam.org/family/PF01645 Pfam PF04898 http://pfam.xfam.org/family/PF04898 Phobius swissprot:GLTB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLTB_ECOLI PhylomeDB P09831 http://phylomedb.org/?seqid=P09831 ProteinModelPortal P09831 http://www.proteinmodelportal.org/query/uniprot/P09831 PubMed 1673677 http://www.ncbi.nlm.nih.gov/pubmed/1673677 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2643092 http://www.ncbi.nlm.nih.gov/pubmed/2643092 PubMed 3326786 http://www.ncbi.nlm.nih.gov/pubmed/3326786 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417679 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417679 RefSeq WP_001300352 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300352 SMR P09831 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P09831 STRING 511145.b3212 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3212&targetmode=cogs STRING COG0067 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0067&targetmode=cogs STRING COG0069 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0069&targetmode=cogs STRING COG0070 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0070&targetmode=cogs SUPFAM SSF56235 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56235 SUPFAM SSF69336 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF69336 UniProtKB GLTB_ECOLI http://www.uniprot.org/uniprot/GLTB_ECOLI UniProtKB-AC P09831 http://www.uniprot.org/uniprot/P09831 charge swissprot:GLTB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLTB_ECOLI eggNOG COG0067 http://eggnogapi.embl.de/nog_data/html/tree/COG0067 eggNOG COG0069 http://eggnogapi.embl.de/nog_data/html/tree/COG0069 eggNOG COG0070 http://eggnogapi.embl.de/nog_data/html/tree/COG0070 eggNOG ENOG4105CBC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CBC epestfind swissprot:GLTB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLTB_ECOLI garnier swissprot:GLTB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLTB_ECOLI helixturnhelix swissprot:GLTB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLTB_ECOLI hmoment swissprot:GLTB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLTB_ECOLI iep swissprot:GLTB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLTB_ECOLI inforesidue swissprot:GLTB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLTB_ECOLI octanol swissprot:GLTB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLTB_ECOLI pepcoil swissprot:GLTB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLTB_ECOLI pepdigest swissprot:GLTB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLTB_ECOLI pepinfo swissprot:GLTB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLTB_ECOLI pepnet swissprot:GLTB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLTB_ECOLI pepstats swissprot:GLTB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLTB_ECOLI pepwheel swissprot:GLTB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLTB_ECOLI pepwindow swissprot:GLTB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLTB_ECOLI sigcleave swissprot:GLTB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLTB_ECOLI ## Database ID URL or Descriptions # BioGrid 4262289 15 # COFACTOR Name=FAD; Xref=ChEBI:CHEBI 57692; Evidence={ECO:0000305}; # EcoGene EG13121 ygcN # FUNCTION YGCN_ECOLI Probably accepts electrons from YgcQ/YgcR and reduces a quinone. # GO_function GO:0016491 oxidoreductase activity; IEA:UniProtKB-KW. # GOslim_function GO:0016491 oxidoreductase activity # Gene3D 3.50.50.60 -; 1. # IntAct Q46904 3 # InterPro IPR023753 FAD/NAD-binding_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00910 Nitrogen metabolism # Organism YGCN_ECOLI Escherichia coli (strain K12) # PATRIC 32120944 VBIEscCol129921_2864 # PIR B65058 B65058 # Pfam PF12831 FAD_oxidored # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGCN_ECOLI Probable electron transfer flavoprotein-quinone oxidoreductase YgcN # RefSeq NP_417246 NC_000913.3 # RefSeq WP_001301334 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA69276.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ETF-QO/FixC family. {ECO 0000305}. # SUPFAM SSF51905 SSF51905; 2 # eggNOG COG0644 LUCA # eggNOG ENOG4105DWH Bacteria BLAST swissprot:YGCN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGCN_ECOLI BioCyc ECOL316407:JW2736-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2736-MONOMER BioCyc EcoCyc:G7432-MONOMER http://biocyc.org/getid?id=EcoCyc:G7432-MONOMER COG COG0644 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0644 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.5.5.- http://www.genome.jp/dbget-bin/www_bget?EC:1.5.5.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 ENZYME 1.5.5.- http://enzyme.expasy.org/EC/1.5.5.- EchoBASE EB2922 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2922 EcoGene EG13121 http://www.ecogene.org/geneInfo.php?eg_id=EG13121 EnsemblBacteria AAC75808 http://www.ensemblgenomes.org/id/AAC75808 EnsemblBacteria AAC75808 http://www.ensemblgenomes.org/id/AAC75808 EnsemblBacteria BAE76843 http://www.ensemblgenomes.org/id/BAE76843 EnsemblBacteria BAE76843 http://www.ensemblgenomes.org/id/BAE76843 EnsemblBacteria BAE76843 http://www.ensemblgenomes.org/id/BAE76843 EnsemblBacteria b2766 http://www.ensemblgenomes.org/id/b2766 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 GeneID 946114 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946114 HOGENOM HOG000018936 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000018936&db=HOGENOM6 InParanoid Q46904 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46904 IntAct Q46904 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46904* IntEnz 1.5.5 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.5.5 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2736 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2736 KEGG_Gene eco:b2766 http://www.genome.jp/dbget-bin/www_bget?eco:b2766 KEGG_Orthology KO:K00313 http://www.genome.jp/dbget-bin/www_bget?KO:K00313 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 OMA RTLIKNT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RTLIKNT PSORT swissprot:YGCN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGCN_ECOLI PSORT-B swissprot:YGCN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGCN_ECOLI PSORT2 swissprot:YGCN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGCN_ECOLI Pfam PF12831 http://pfam.xfam.org/family/PF12831 Phobius swissprot:YGCN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGCN_ECOLI PhylomeDB Q46904 http://phylomedb.org/?seqid=Q46904 ProteinModelPortal Q46904 http://www.proteinmodelportal.org/query/uniprot/Q46904 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417246 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417246 RefSeq WP_001301334 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001301334 SMR Q46904 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46904 STRING 511145.b2766 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2766&targetmode=cogs STRING COG0644 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0644&targetmode=cogs SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 UniProtKB YGCN_ECOLI http://www.uniprot.org/uniprot/YGCN_ECOLI UniProtKB-AC Q46904 http://www.uniprot.org/uniprot/Q46904 charge swissprot:YGCN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGCN_ECOLI eggNOG COG0644 http://eggnogapi.embl.de/nog_data/html/tree/COG0644 eggNOG ENOG4105DWH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DWH epestfind swissprot:YGCN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGCN_ECOLI garnier swissprot:YGCN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGCN_ECOLI helixturnhelix swissprot:YGCN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGCN_ECOLI hmoment swissprot:YGCN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGCN_ECOLI iep swissprot:YGCN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGCN_ECOLI inforesidue swissprot:YGCN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGCN_ECOLI octanol swissprot:YGCN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGCN_ECOLI pepcoil swissprot:YGCN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGCN_ECOLI pepdigest swissprot:YGCN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGCN_ECOLI pepinfo swissprot:YGCN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGCN_ECOLI pepnet swissprot:YGCN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGCN_ECOLI pepstats swissprot:YGCN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGCN_ECOLI pepwheel swissprot:YGCN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGCN_ECOLI pepwindow swissprot:YGCN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGCN_ECOLI sigcleave swissprot:YGCN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGCN_ECOLI ## Database ID URL or Descriptions # BioGrid 4260746 7 # CDD cd06261 TM_PBP2 # EcoGene EG10198 cysW # FUNCTION CYSW_ECOLI Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015419 ATPase-coupled sulfate transmembrane transporter activity; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # Gene3D 1.10.3720.10 -; 1. # InterPro IPR000515 MetI-like # InterPro IPR005667 Sulph_transpt2 # InterPro IPR011866 CysW_permease # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00185 Sulfate transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism CYSW_ECOLI Escherichia coli (strain K12) # PATRIC 32120231 VBIEscCol129921_2518 # PIR F65016 QRECSW # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CYSW_ECOLI Sulfate transport system permease protein CysW # RefSeq WP_000852686 NZ_LN832404.1 # RefSeq YP_026168 NC_000913.3 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION CYSW_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute- binding protein (CysP). {ECO 0000305}. # SUPFAM SSF161098 SSF161098 # TCDB 3.A.1.6 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR00969 3a0106s02 # TIGRFAMs TIGR02140 permease_CysW # eggNOG COG4208 LUCA # eggNOG ENOG4105ECW Bacteria BLAST swissprot:CYSW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CYSW_ECOLI BioCyc ECOL316407:JW2416-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2416-MONOMER BioCyc EcoCyc:CYSW-MONOMER http://biocyc.org/getid?id=EcoCyc:CYSW-MONOMER BioCyc MetaCyc:CYSW-MONOMER http://biocyc.org/getid?id=MetaCyc:CYSW-MONOMER COG COG0555 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0555 DIP DIP-9388N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9388N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M32101 http://www.ebi.ac.uk/ena/data/view/M32101 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0195 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0195 EcoGene EG10198 http://www.ecogene.org/geneInfo.php?eg_id=EG10198 EnsemblBacteria AAC75476 http://www.ensemblgenomes.org/id/AAC75476 EnsemblBacteria AAC75476 http://www.ensemblgenomes.org/id/AAC75476 EnsemblBacteria BAA16297 http://www.ensemblgenomes.org/id/BAA16297 EnsemblBacteria BAA16297 http://www.ensemblgenomes.org/id/BAA16297 EnsemblBacteria BAA16297 http://www.ensemblgenomes.org/id/BAA16297 EnsemblBacteria b2423 http://www.ensemblgenomes.org/id/b2423 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015419 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015419 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 2847743 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2847743 HOGENOM HOG000263697 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000263697&db=HOGENOM6 InParanoid P0AEB0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEB0 IntAct P0AEB0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEB0* InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 InterPro IPR005667 http://www.ebi.ac.uk/interpro/entry/IPR005667 InterPro IPR011866 http://www.ebi.ac.uk/interpro/entry/IPR011866 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2416 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2416 KEGG_Gene eco:b2423 http://www.genome.jp/dbget-bin/www_bget?eco:b2423 KEGG_Orthology KO:K02047 http://www.genome.jp/dbget-bin/www_bget?KO:K02047 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 MINT MINT-1250777 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1250777 OMA YQFSAAF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YQFSAAF PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:CYSW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CYSW_ECOLI PSORT-B swissprot:CYSW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CYSW_ECOLI PSORT2 swissprot:CYSW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CYSW_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Phobius swissprot:CYSW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CYSW_ECOLI PhylomeDB P0AEB0 http://phylomedb.org/?seqid=P0AEB0 ProteinModelPortal P0AEB0 http://www.proteinmodelportal.org/query/uniprot/P0AEB0 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2188958 http://www.ncbi.nlm.nih.gov/pubmed/2188958 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000852686 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000852686 RefSeq YP_026168 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026168 SMR P0AEB0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEB0 STRING 511145.b2423 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2423&targetmode=cogs STRING COG0555 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0555&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.6 http://www.tcdb.org/search/result.php?tc=3.A.1.6 TIGRFAMs TIGR00969 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00969 TIGRFAMs TIGR02140 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02140 UniProtKB CYSW_ECOLI http://www.uniprot.org/uniprot/CYSW_ECOLI UniProtKB-AC P0AEB0 http://www.uniprot.org/uniprot/P0AEB0 charge swissprot:CYSW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CYSW_ECOLI eggNOG COG4208 http://eggnogapi.embl.de/nog_data/html/tree/COG4208 eggNOG ENOG4105ECW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ECW epestfind swissprot:CYSW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CYSW_ECOLI garnier swissprot:CYSW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CYSW_ECOLI helixturnhelix swissprot:CYSW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CYSW_ECOLI hmoment swissprot:CYSW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CYSW_ECOLI iep swissprot:CYSW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CYSW_ECOLI inforesidue swissprot:CYSW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CYSW_ECOLI octanol swissprot:CYSW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CYSW_ECOLI pepcoil swissprot:CYSW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CYSW_ECOLI pepdigest swissprot:CYSW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CYSW_ECOLI pepinfo swissprot:CYSW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CYSW_ECOLI pepnet swissprot:CYSW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CYSW_ECOLI pepstats swissprot:CYSW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CYSW_ECOLI pepwheel swissprot:CYSW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CYSW_ECOLI pepwindow swissprot:CYSW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CYSW_ECOLI sigcleave swissprot:CYSW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CYSW_ECOLI ## Database ID URL or Descriptions # AltName ARGC_ECOLI N-acetyl-glutamate semialdehyde dehydrogenase # BRENDA 1.2.1.38 2026 # BioGrid 4262190 6 # CATALYTIC ACTIVITY ARGC_ECOLI N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. # EcoGene EG10065 argC # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003942 N-acetyl-gamma-glutamyl-phosphate reductase activity; IDA:EcoCyc. # GO_function GO:0051287 NAD binding; IEA:InterPro. # GO_process GO:0006526 arginine biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.720 -; 1. # HAMAP MF_00150 ArgC_type1 # InterPro IPR000534 Semialdehyde_DH_NAD-bd # InterPro IPR000706 AGPR_type-1 # InterPro IPR012280 Semialdhyde_DH_dimer_dom # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR023013 AGPR_AS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00330 Arginine and proline metabolism # Organism ARGC_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-arginine biosynthesis; N(2)- acetyl-L-ornithine from L-glutamate step 3/4. # PATRIC 32123437 VBIEscCol129921_4079 # PIR JT0332 RDECEP # PROSITE PS01224 ARGC # Pfam PF01118 Semialdhyde_dh # Pfam PF02774 Semialdhyde_dhC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ARGC_ECOLI N-acetyl-gamma-glutamyl-phosphate reductase # RefSeq NP_418393 NC_000913.3 # RefSeq WP_000935370 NZ_LN832404.1 # SIMILARITY Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. {ECO 0000305}. # SMART SM00859 Semialdhyde_dh # SUBCELLULAR LOCATION ARGC_ECOLI Cytoplasm {ECO 0000250}. # SUPFAM SSF51735 SSF51735 # TIGRFAMs TIGR01850 argC # UniPathway UPA00068 UER00108 # eggNOG COG0002 LUCA # eggNOG ENOG4105C0N Bacteria BLAST swissprot:ARGC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARGC_ECOLI BioCyc ECOL316407:JW3930-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3930-MONOMER BioCyc EcoCyc:N-ACETYLGLUTPREDUCT-MONOMER http://biocyc.org/getid?id=EcoCyc:N-ACETYLGLUTPREDUCT-MONOMER BioCyc MetaCyc:N-ACETYLGLUTPREDUCT-MONOMER http://biocyc.org/getid?id=MetaCyc:N-ACETYLGLUTPREDUCT-MONOMER COG COG0002 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0002 DOI 10.1016/0378-1119(88)90030-3 http://dx.doi.org/10.1016/0378-1119(88)90030-3 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/10.24.8031 http://dx.doi.org/10.1093/nar/10.24.8031 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.2.1.38 http://www.genome.jp/dbget-bin/www_bget?EC:1.2.1.38 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01587 http://www.ebi.ac.uk/ena/data/view/J01587 EMBL M21446 http://www.ebi.ac.uk/ena/data/view/M21446 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X55417 http://www.ebi.ac.uk/ena/data/view/X55417 ENZYME 1.2.1.38 http://enzyme.expasy.org/EC/1.2.1.38 EchoBASE EB0063 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0063 EcoGene EG10065 http://www.ecogene.org/geneInfo.php?eg_id=EG10065 EnsemblBacteria AAC76940 http://www.ensemblgenomes.org/id/AAC76940 EnsemblBacteria AAC76940 http://www.ensemblgenomes.org/id/AAC76940 EnsemblBacteria BAE77353 http://www.ensemblgenomes.org/id/BAE77353 EnsemblBacteria BAE77353 http://www.ensemblgenomes.org/id/BAE77353 EnsemblBacteria BAE77353 http://www.ensemblgenomes.org/id/BAE77353 EnsemblBacteria b3958 http://www.ensemblgenomes.org/id/b3958 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003942 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003942 GO_function GO:0051287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051287 GO_process GO:0006526 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006526 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 948455 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948455 HAMAP MF_00150 http://hamap.expasy.org/unirule/MF_00150 HOGENOM HOG000254902 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000254902&db=HOGENOM6 InParanoid P11446 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P11446 IntAct P11446 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P11446* IntEnz 1.2.1.38 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.2.1.38 InterPro IPR000534 http://www.ebi.ac.uk/interpro/entry/IPR000534 InterPro IPR000706 http://www.ebi.ac.uk/interpro/entry/IPR000706 InterPro IPR012280 http://www.ebi.ac.uk/interpro/entry/IPR012280 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR023013 http://www.ebi.ac.uk/interpro/entry/IPR023013 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3930 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3930 KEGG_Gene eco:b3958 http://www.genome.jp/dbget-bin/www_bget?eco:b3958 KEGG_Orthology KO:K00145 http://www.genome.jp/dbget-bin/www_bget?KO:K00145 KEGG_Pathway ko00330 http://www.genome.jp/kegg-bin/show_pathway?ko00330 KEGG_Reaction rn:R03443 http://www.genome.jp/dbget-bin/www_bget?rn:R03443 OMA TFVPHLT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TFVPHLT PROSITE PS01224 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01224 PSORT swissprot:ARGC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARGC_ECOLI PSORT-B swissprot:ARGC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARGC_ECOLI PSORT2 swissprot:ARGC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARGC_ECOLI Pfam PF01118 http://pfam.xfam.org/family/PF01118 Pfam PF02774 http://pfam.xfam.org/family/PF02774 Phobius swissprot:ARGC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARGC_ECOLI PhylomeDB P11446 http://phylomedb.org/?seqid=P11446 ProteinModelPortal P11446 http://www.proteinmodelportal.org/query/uniprot/P11446 PubMed 1551850 http://www.ncbi.nlm.nih.gov/pubmed/1551850 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2851495 http://www.ncbi.nlm.nih.gov/pubmed/2851495 PubMed 6761650 http://www.ncbi.nlm.nih.gov/pubmed/6761650 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418393 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418393 RefSeq WP_000935370 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000935370 SMART SM00859 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00859 SMR P11446 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P11446 STRING 511145.b3958 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3958&targetmode=cogs STRING COG0002 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0002&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 TIGRFAMs TIGR01850 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01850 UniProtKB ARGC_ECOLI http://www.uniprot.org/uniprot/ARGC_ECOLI UniProtKB-AC P11446 http://www.uniprot.org/uniprot/P11446 charge swissprot:ARGC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARGC_ECOLI eggNOG COG0002 http://eggnogapi.embl.de/nog_data/html/tree/COG0002 eggNOG ENOG4105C0N http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C0N epestfind swissprot:ARGC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARGC_ECOLI garnier swissprot:ARGC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARGC_ECOLI helixturnhelix swissprot:ARGC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARGC_ECOLI hmoment swissprot:ARGC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARGC_ECOLI iep swissprot:ARGC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARGC_ECOLI inforesidue swissprot:ARGC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARGC_ECOLI octanol swissprot:ARGC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARGC_ECOLI pepcoil swissprot:ARGC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARGC_ECOLI pepdigest swissprot:ARGC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARGC_ECOLI pepinfo swissprot:ARGC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARGC_ECOLI pepnet swissprot:ARGC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARGC_ECOLI pepstats swissprot:ARGC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARGC_ECOLI pepwheel swissprot:ARGC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARGC_ECOLI pepwindow swissprot:ARGC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARGC_ECOLI sigcleave swissprot:ARGC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARGC_ECOLI ## Database ID URL or Descriptions # AltName NUOE_ECOLI NADH dehydrogenase I subunit E # AltName NUOE_ECOLI NDH-1 subunit E # AltName NUOE_ECOLI NUO5 # BioGrid 4262977 15 # CATALYTIC ACTIVITY NUOE_ECOLI NADH + a quinone = NAD(+) + a quinol. # COFACTOR NUOE_ECOLI Name=[2Fe-2S] cluster; Xref=ChEBI CHEBI 49601; Evidence={ECO 0000305}; Note=Binds 1 [2Fe-2S] cluster. {ECO 0000305}; # EcoGene EG12086 nuoE # FUNCTION NUOE_ECOLI NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. # GO_component GO:0005886 plasma membrane; IDA:EcoliWiki. # GO_component GO:0030964 NADH dehydrogenase complex; IDA:EcoliWiki. # GO_component GO:0045272 plasma membrane respiratory chain complex I; IDA:EcoCyc. # GO_function GO:0008137 NADH dehydrogenase (ubiquinone) activity; IBA:GO_Central. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0048038 quinone binding; IEA:UniProtKB-KW. # GO_function GO:0051537 2 iron, 2 sulfur cluster binding; ISS:EcoCyc. # GO_process GO:0022904 respiratory electron transport chain; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # Gene3D 3.40.30.10 -; 1. # INTERACTION NUOE_ECOLI P33602 nuoG; NbExp=4; IntAct=EBI-1117136, EBI-559737; # IntAct P0AFD1 31 # InterPro IPR002023 NuoE-like # InterPro IPR012336 Thioredoxin-like_fold # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00190 Oxidative phosphorylation # KEGG_Pathway ko00910 Nitrogen metabolism # Organism NUOE_ECOLI Escherichia coli (strain K12) # PATRIC 32119937 VBIEscCol129921_2378 # PIR C65000 C65000 # PIRSF PIRSF000216 NADH_DH_24kDa # PROSITE PS01099 COMPLEX1_24K # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NUOE_ECOLI NADH-quinone oxidoreductase subunit E # RefSeq NP_416788 NC_000913.3 # RefSeq WP_000545042 NZ_LN832404.1 # SIMILARITY Belongs to the complex I 24 kDa subunit family. {ECO 0000305}. # SUBUNIT NUOE_ECOLI Composed of 13 different subunits. Subunits NuoCD, E, F, and G constitute the peripheral sector of the complex. # SUPFAM SSF52833 SSF52833 # TCDB 3.D.1.1 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family # TIGRFAMs TIGR01958 nuoE_fam # eggNOG COG1905 LUCA # eggNOG ENOG4105GKE Bacteria BLAST swissprot:NUOE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NUOE_ECOLI BioCyc ECOL316407:JW2280-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2280-MONOMER BioCyc EcoCyc:NUOE-MONOMER http://biocyc.org/getid?id=EcoCyc:NUOE-MONOMER BioCyc MetaCyc:NUOE-MONOMER http://biocyc.org/getid?id=MetaCyc:NUOE-MONOMER COG COG1905 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1905 DIP DIP-35917N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35917N DOI 10.1006/jmbi.1993.1488 http://dx.doi.org/10.1006/jmbi.1993.1488 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1432-1033.1995.tb20594.x http://dx.doi.org/10.1111/j.1432-1033.1995.tb20594.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.6.5.11 http://www.genome.jp/dbget-bin/www_bget?EC:1.6.5.11 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L25055 http://www.ebi.ac.uk/ena/data/view/L25055 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X68301 http://www.ebi.ac.uk/ena/data/view/X68301 ENZYME 1.6.5.11 http://enzyme.expasy.org/EC/1.6.5.11 EchoBASE EB2010 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2010 EcoGene EG12086 http://www.ecogene.org/geneInfo.php?eg_id=EG12086 EnsemblBacteria AAC75345 http://www.ensemblgenomes.org/id/AAC75345 EnsemblBacteria AAC75345 http://www.ensemblgenomes.org/id/AAC75345 EnsemblBacteria BAA16114 http://www.ensemblgenomes.org/id/BAA16114 EnsemblBacteria BAA16114 http://www.ensemblgenomes.org/id/BAA16114 EnsemblBacteria BAA16114 http://www.ensemblgenomes.org/id/BAA16114 EnsemblBacteria b2285 http://www.ensemblgenomes.org/id/b2285 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0030964 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030964 GO_component GO:0045272 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045272 GO_function GO:0008137 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008137 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0048038 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048038 GO_function GO:0051537 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051537 GO_process GO:0022904 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022904 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 Gene3D 3.40.30.10 http://www.cathdb.info/version/latest/superfamily/3.40.30.10 GeneID 946746 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946746 HOGENOM HOG000257749 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000257749&db=HOGENOM6 InParanoid P0AFD1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFD1 IntAct P0AFD1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFD1* IntEnz 1.6.5.11 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.6.5.11 InterPro IPR002023 http://www.ebi.ac.uk/interpro/entry/IPR002023 InterPro IPR012336 http://www.ebi.ac.uk/interpro/entry/IPR012336 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2280 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2280 KEGG_Gene eco:b2285 http://www.genome.jp/dbget-bin/www_bget?eco:b2285 KEGG_Orthology KO:K00334 http://www.genome.jp/dbget-bin/www_bget?KO:K00334 KEGG_Pathway ko00190 http://www.genome.jp/kegg-bin/show_pathway?ko00190 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Reaction rn:R02166 http://www.genome.jp/dbget-bin/www_bget?rn:R02166 OMA CDKGPSM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CDKGPSM PROSITE PS01099 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01099 PSORT swissprot:NUOE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NUOE_ECOLI PSORT-B swissprot:NUOE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NUOE_ECOLI PSORT2 swissprot:NUOE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NUOE_ECOLI Phobius swissprot:NUOE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NUOE_ECOLI PhylomeDB P0AFD1 http://phylomedb.org/?seqid=P0AFD1 ProteinModelPortal P0AFD1 http://www.proteinmodelportal.org/query/uniprot/P0AFD1 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7607227 http://www.ncbi.nlm.nih.gov/pubmed/7607227 PubMed 7690854 http://www.ncbi.nlm.nih.gov/pubmed/7690854 PubMed 8157582 http://www.ncbi.nlm.nih.gov/pubmed/8157582 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416788 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416788 RefSeq WP_000545042 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000545042 SMR P0AFD1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFD1 STRING 511145.b2285 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2285&targetmode=cogs STRING COG1905 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1905&targetmode=cogs SUPFAM SSF52833 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52833 TCDB 3.D.1.1 http://www.tcdb.org/search/result.php?tc=3.D.1.1 TIGRFAMs TIGR01958 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01958 UniProtKB NUOE_ECOLI http://www.uniprot.org/uniprot/NUOE_ECOLI UniProtKB-AC P0AFD1 http://www.uniprot.org/uniprot/P0AFD1 charge swissprot:NUOE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NUOE_ECOLI eggNOG COG1905 http://eggnogapi.embl.de/nog_data/html/tree/COG1905 eggNOG ENOG4105GKE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105GKE epestfind swissprot:NUOE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NUOE_ECOLI garnier swissprot:NUOE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NUOE_ECOLI helixturnhelix swissprot:NUOE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NUOE_ECOLI hmoment swissprot:NUOE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NUOE_ECOLI iep swissprot:NUOE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NUOE_ECOLI inforesidue swissprot:NUOE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NUOE_ECOLI octanol swissprot:NUOE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NUOE_ECOLI pepcoil swissprot:NUOE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NUOE_ECOLI pepdigest swissprot:NUOE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NUOE_ECOLI pepinfo swissprot:NUOE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NUOE_ECOLI pepnet swissprot:NUOE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NUOE_ECOLI pepstats swissprot:NUOE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NUOE_ECOLI pepwheel swissprot:NUOE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NUOE_ECOLI pepwindow swissprot:NUOE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NUOE_ECOLI sigcleave swissprot:NUOE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NUOE_ECOLI ## Database ID URL or Descriptions # AltName MQO_ECOLI MQO # AltName MQO_ECOLI Malate dehydrogenase [quinone] # CATALYTIC ACTIVITY MQO_ECOLI (S)-malate + a quinone = oxaloacetate + reduced quinone. # COFACTOR Name=FAD; Xref=ChEBI:CHEBI 57692; Evidence={ECO:0000250}; # EcoGene EG12069 mqo # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0009898 cytoplasmic side of plasma membrane; IDA:EcoCyc. # GO_function GO:0008924 malate dehydrogenase (quinone) activity; IDA:EcoCyc. # GO_function GO:0050660 flavin adenine dinucleotide binding; IDA:EcoCyc. # GO_function GO:0052589 malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC. # GO_process GO:0006099 tricarboxylic acid cycle; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.50.50.60 -; 2. # HAMAP MF_00212 MQO # IntAct P33940 18 # InterPro IPR006231 MQO # InterPro IPR023753 FAD/NAD-binding_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00620 Pyruvate metabolism # Organism MQO_ECOLI Escherichia coli (strain K12) # PATHWAY Carbohydrate metabolism; tricarboxylic acid cycle; oxaloacetate from (S)-malate (quinone route) step 1/1. # PATRIC 32119779 VBIEscCol129921_2299 # PIR H64990 H64990 # Pfam PF06039 Mqo # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Malate quinone oxidoreductase # RefSeq NP_416714 NC_000913.3 # RefSeq WP_000758077 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA16402.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the MQO family. {ECO 0000305}. # SUPFAM SSF51905 SSF51905; 2 # TIGRFAMs TIGR01320 mal_quin_oxido # UniPathway UPA00223 UER01008 # eggNOG COG0579 LUCA # eggNOG ENOG4105DWT Bacteria BLAST swissprot:MQO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MQO_ECOLI BioCyc ECOL316407:JW2198-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2198-MONOMER BioCyc EcoCyc:EG12069-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12069-MONOMER BioCyc MetaCyc:EG12069-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12069-MONOMER COG COG0579 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0579 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.11.3204-3209.2000 http://dx.doi.org/10.1128/JB.182.11.3204-3209.2000 EC_number EC:1.1.5.4 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.5.4 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00008 http://www.ebi.ac.uk/ena/data/view/U00008 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.1.5.4 http://enzyme.expasy.org/EC/1.1.5.4 EchoBASE EB1996 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1996 EcoGene EG12069 http://www.ecogene.org/geneInfo.php?eg_id=EG12069 EnsemblBacteria AAC75270 http://www.ensemblgenomes.org/id/AAC75270 EnsemblBacteria AAC75270 http://www.ensemblgenomes.org/id/AAC75270 EnsemblBacteria BAA15993 http://www.ensemblgenomes.org/id/BAA15993 EnsemblBacteria BAA15993 http://www.ensemblgenomes.org/id/BAA15993 EnsemblBacteria BAA15993 http://www.ensemblgenomes.org/id/BAA15993 EnsemblBacteria b2210 http://www.ensemblgenomes.org/id/b2210 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0009898 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009898 GO_function GO:0008924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008924 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_function GO:0052589 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052589 GO_process GO:0006099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006099 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 GeneID 946702 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946702 HAMAP MF_00212 http://hamap.expasy.org/unirule/MF_00212 HOGENOM HOG000109379 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000109379&db=HOGENOM6 InParanoid P33940 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33940 IntAct P33940 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33940* IntEnz 1.1.5.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.5.4 InterPro IPR006231 http://www.ebi.ac.uk/interpro/entry/IPR006231 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2198 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2198 KEGG_Gene eco:b2210 http://www.genome.jp/dbget-bin/www_bget?eco:b2210 KEGG_Orthology KO:K00116 http://www.genome.jp/dbget-bin/www_bget?KO:K00116 KEGG_Pathway ko00620 http://www.genome.jp/kegg-bin/show_pathway?ko00620 KEGG_Reaction rn:R01257 http://www.genome.jp/dbget-bin/www_bget?rn:R01257 OMA EPIAATK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EPIAATK PSORT swissprot:MQO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MQO_ECOLI PSORT-B swissprot:MQO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MQO_ECOLI PSORT2 swissprot:MQO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MQO_ECOLI Pfam PF06039 http://pfam.xfam.org/family/PF06039 Phobius swissprot:MQO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MQO_ECOLI PhylomeDB P33940 http://phylomedb.org/?seqid=P33940 ProteinModelPortal P33940 http://www.proteinmodelportal.org/query/uniprot/P33940 PubMed 10809701 http://www.ncbi.nlm.nih.gov/pubmed/10809701 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416714 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416714 RefSeq WP_000758077 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000758077 STRING 511145.b2210 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2210&targetmode=cogs STRING COG0579 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0579&targetmode=cogs SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 TIGRFAMs TIGR01320 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01320 UniProtKB MQO_ECOLI http://www.uniprot.org/uniprot/MQO_ECOLI UniProtKB-AC P33940 http://www.uniprot.org/uniprot/P33940 charge swissprot:MQO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MQO_ECOLI eggNOG COG0579 http://eggnogapi.embl.de/nog_data/html/tree/COG0579 eggNOG ENOG4105DWT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DWT epestfind swissprot:MQO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MQO_ECOLI garnier swissprot:MQO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MQO_ECOLI helixturnhelix swissprot:MQO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MQO_ECOLI hmoment swissprot:MQO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MQO_ECOLI iep swissprot:MQO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MQO_ECOLI inforesidue swissprot:MQO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MQO_ECOLI octanol swissprot:MQO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MQO_ECOLI pepcoil swissprot:MQO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MQO_ECOLI pepdigest swissprot:MQO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MQO_ECOLI pepinfo swissprot:MQO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MQO_ECOLI pepnet swissprot:MQO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MQO_ECOLI pepstats swissprot:MQO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MQO_ECOLI pepwheel swissprot:MQO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MQO_ECOLI pepwindow swissprot:MQO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MQO_ECOLI sigcleave swissprot:MQO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MQO_ECOLI ## Database ID URL or Descriptions # AltName IDNO_ECOLI 5-keto-D-gluconate 5-reductase # BioGrid 4262730 6 # CATALYTIC ACTIVITY IDNO_ECOLI D-gluconate + NAD(P)(+) = 5-dehydro-D- gluconate + NAD(P)H. # EcoGene EG12540 idnO # FUNCTION IDNO_ECOLI Catalyzes a reversible reduction of 5-ketoglutanate to form D-gluconate. Dependent on NADP, almost inactive with NAD. {ECO 0000269|PubMed 9658018}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0008874 gluconate 5-dehydrogenase activity; IDA:EcoCyc. # GO_process GO:0019521 D-gluconate metabolic process; IEA:UniProtKB-KW. # GO_process GO:0046183 L-idonate catabolic process; IEP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.720 -; 1. # IntAct P0A9P9 7 # InterPro IPR002347 SDR_fam # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR020904 Sc_DH/Rdtase_CS # KEGG_Brite ko01000 Enzymes # Organism IDNO_ECOLI Escherichia coli (strain K12) # PANTHER PTHR24322 PTHR24322; 2 # PATHWAY IDNO_ECOLI Carbohydrate acid metabolism; L-idonate degradation. # PATRIC 32124105 VBIEscCol129921_4397 # PIR S56492 S56492 # PRINTS PR00080 SDRFAMILY # PRINTS PR00081 GDHRDH # PROSITE PS00061 ADH_SHORT # Pfam PF00106 adh_short # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName IDNO_ECOLI Gluconate 5-dehydrogenase # RefSeq NP_418687 NC_000913.3 # RefSeq WP_000998695 NZ_LN832404.1 # SIMILARITY Belongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO 0000305}. # SUBCELLULAR LOCATION IDNO_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF51735 SSF51735 # eggNOG ENOG4105CHR Bacteria # eggNOG ENOG410XNW1 LUCA BLAST swissprot:IDNO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:IDNO_ECOLI BioCyc ECOL316407:JW4223-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4223-MONOMER BioCyc EcoCyc:GLUCONREDUCT-MONOMER http://biocyc.org/getid?id=EcoCyc:GLUCONREDUCT-MONOMER BioCyc MetaCyc:GLUCONREDUCT-MONOMER http://biocyc.org/getid?id=MetaCyc:GLUCONREDUCT-MONOMER COG COG1028 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1028 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.69 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.69 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 1.1.1.69 http://enzyme.expasy.org/EC/1.1.1.69 EchoBASE EB2429 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2429 EcoGene EG12540 http://www.ecogene.org/geneInfo.php?eg_id=EG12540 EnsemblBacteria AAC77223 http://www.ensemblgenomes.org/id/AAC77223 EnsemblBacteria AAC77223 http://www.ensemblgenomes.org/id/AAC77223 EnsemblBacteria BAE78263 http://www.ensemblgenomes.org/id/BAE78263 EnsemblBacteria BAE78263 http://www.ensemblgenomes.org/id/BAE78263 EnsemblBacteria BAE78263 http://www.ensemblgenomes.org/id/BAE78263 EnsemblBacteria b4266 http://www.ensemblgenomes.org/id/b4266 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0008874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008874 GO_process GO:0019521 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019521 GO_process GO:0046183 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046183 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 947109 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947109 InParanoid P0A9P9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9P9 IntAct P0A9P9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9P9* IntEnz 1.1.1.69 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.69 InterPro IPR002347 http://www.ebi.ac.uk/interpro/entry/IPR002347 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR020904 http://www.ebi.ac.uk/interpro/entry/IPR020904 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4223 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4223 KEGG_Gene eco:b4266 http://www.genome.jp/dbget-bin/www_bget?eco:b4266 KEGG_Orthology KO:K00046 http://www.genome.jp/dbget-bin/www_bget?KO:K00046 MINT MINT-1231433 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1231433 OMA AFHELDV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AFHELDV PANTHER PTHR24322 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24322 PRINTS PR00080 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00080 PRINTS PR00081 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00081 PROSITE PS00061 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00061 PSORT swissprot:IDNO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:IDNO_ECOLI PSORT-B swissprot:IDNO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:IDNO_ECOLI PSORT2 swissprot:IDNO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:IDNO_ECOLI Pfam PF00106 http://pfam.xfam.org/family/PF00106 Phobius swissprot:IDNO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:IDNO_ECOLI PhylomeDB P0A9P9 http://phylomedb.org/?seqid=P0A9P9 ProteinModelPortal P0A9P9 http://www.proteinmodelportal.org/query/uniprot/P0A9P9 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9658018 http://www.ncbi.nlm.nih.gov/pubmed/9658018 RefSeq NP_418687 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418687 RefSeq WP_000998695 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000998695 SMR P0A9P9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9P9 STRING 511145.b4266 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4266&targetmode=cogs STRING COG1028 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1028&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB IDNO_ECOLI http://www.uniprot.org/uniprot/IDNO_ECOLI UniProtKB-AC P0A9P9 http://www.uniprot.org/uniprot/P0A9P9 charge swissprot:IDNO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:IDNO_ECOLI eggNOG ENOG4105CHR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CHR eggNOG ENOG410XNW1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNW1 epestfind swissprot:IDNO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:IDNO_ECOLI garnier swissprot:IDNO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:IDNO_ECOLI helixturnhelix swissprot:IDNO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:IDNO_ECOLI hmoment swissprot:IDNO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:IDNO_ECOLI iep swissprot:IDNO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:IDNO_ECOLI inforesidue swissprot:IDNO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:IDNO_ECOLI octanol swissprot:IDNO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:IDNO_ECOLI pepcoil swissprot:IDNO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:IDNO_ECOLI pepdigest swissprot:IDNO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:IDNO_ECOLI pepinfo swissprot:IDNO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:IDNO_ECOLI pepnet swissprot:IDNO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:IDNO_ECOLI pepstats swissprot:IDNO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:IDNO_ECOLI pepwheel swissprot:IDNO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:IDNO_ECOLI pepwindow swissprot:IDNO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:IDNO_ECOLI sigcleave swissprot:IDNO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:IDNO_ECOLI ## Database ID URL or Descriptions # BioGrid 4262175 7 # EcoGene EG12023 yohJ # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # HAMAP MF_01144 UPF0299 # InterPro IPR005538 LrgA/CidA # InterPro IPR022957 Uncharacterised_UPF0299 # KEGG_Brite ko02000 Transporters # Organism YOHJ_ECOLI Escherichia coli (strain K12) # PATRIC 32119625 VBIEscCol129921_2223 # PIR D64982 D64982 # Pfam PF03788 LrgA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YOHJ_ECOLI UPF0299 membrane protein YohJ # RefSeq NP_416646 NC_000913.3 # RefSeq WP_001295452 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0299 family. {ECO 0000305}. # SUBCELLULAR LOCATION YOHJ_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG COG1380 LUCA # eggNOG ENOG4105VAW Bacteria BLAST swissprot:YOHJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YOHJ_ECOLI BioCyc ECOL316407:JW2129-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2129-MONOMER BioCyc EcoCyc:EG12023-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12023-MONOMER COG COG1380 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1380 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1958 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1958 EcoGene EG12023 http://www.ecogene.org/geneInfo.php?eg_id=EG12023 EnsemblBacteria AAC75202 http://www.ensemblgenomes.org/id/AAC75202 EnsemblBacteria AAC75202 http://www.ensemblgenomes.org/id/AAC75202 EnsemblBacteria BAE76618 http://www.ensemblgenomes.org/id/BAE76618 EnsemblBacteria BAE76618 http://www.ensemblgenomes.org/id/BAE76618 EnsemblBacteria BAE76618 http://www.ensemblgenomes.org/id/BAE76618 EnsemblBacteria b2141 http://www.ensemblgenomes.org/id/b2141 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 949127 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949127 HAMAP MF_01144 http://hamap.expasy.org/unirule/MF_01144 HOGENOM HOG000253615 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000253615&db=HOGENOM6 InParanoid P60632 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P60632 IntAct P60632 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P60632* InterPro IPR005538 http://www.ebi.ac.uk/interpro/entry/IPR005538 InterPro IPR022957 http://www.ebi.ac.uk/interpro/entry/IPR022957 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2129 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2129 KEGG_Gene eco:b2141 http://www.genome.jp/dbget-bin/www_bget?eco:b2141 KEGG_Orthology KO:K06518 http://www.genome.jp/dbget-bin/www_bget?KO:K06518 OMA GIPSSIW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GIPSSIW PSORT swissprot:YOHJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YOHJ_ECOLI PSORT-B swissprot:YOHJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YOHJ_ECOLI PSORT2 swissprot:YOHJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YOHJ_ECOLI Pfam PF03788 http://pfam.xfam.org/family/PF03788 Phobius swissprot:YOHJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YOHJ_ECOLI PhylomeDB P60632 http://phylomedb.org/?seqid=P60632 ProteinModelPortal P60632 http://www.proteinmodelportal.org/query/uniprot/P60632 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416646 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416646 RefSeq WP_001295452 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295452 STRING 511145.b2141 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2141&targetmode=cogs STRING COG1380 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1380&targetmode=cogs UniProtKB YOHJ_ECOLI http://www.uniprot.org/uniprot/YOHJ_ECOLI UniProtKB-AC P60632 http://www.uniprot.org/uniprot/P60632 charge swissprot:YOHJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YOHJ_ECOLI eggNOG COG1380 http://eggnogapi.embl.de/nog_data/html/tree/COG1380 eggNOG ENOG4105VAW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VAW epestfind swissprot:YOHJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YOHJ_ECOLI garnier swissprot:YOHJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YOHJ_ECOLI helixturnhelix swissprot:YOHJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YOHJ_ECOLI hmoment swissprot:YOHJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YOHJ_ECOLI iep swissprot:YOHJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YOHJ_ECOLI inforesidue swissprot:YOHJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YOHJ_ECOLI octanol swissprot:YOHJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YOHJ_ECOLI pepcoil swissprot:YOHJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YOHJ_ECOLI pepdigest swissprot:YOHJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YOHJ_ECOLI pepinfo swissprot:YOHJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YOHJ_ECOLI pepnet swissprot:YOHJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YOHJ_ECOLI pepstats swissprot:YOHJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YOHJ_ECOLI pepwheel swissprot:YOHJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YOHJ_ECOLI pepwindow swissprot:YOHJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YOHJ_ECOLI sigcleave swissprot:YOHJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YOHJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4262473 7 # ESTHER ecoli-yhet abh_upf0017 # EcoGene EG12904 yheT # GO_function GO:0050526 poly(3-hydroxybutyrate) depolymerase activity; ISM:EcoliWiki. # GOslim_function GO:0003674 molecular_function # Gene3D 3.40.50.1820 -; 2. # IntAct P45524 2 # InterPro IPR000073 AB_hydrolase_1 # InterPro IPR000952 AB_hydrolase_4_CS # InterPro IPR012020 ABHD4 # InterPro IPR029058 AB_hydrolase # Organism YHET_ECOLI Escherichia coli (strain K12) # PATRIC 32122140 VBIEscCol129921_3447 # PIR D65129 D65129 # PIRSF PIRSF005211 Ab_hydro_YheT # PROSITE PS01133 UPF0017 # Pfam PF00561 Abhydrolase_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHET_ECOLI Putative esterase YheT # RefSeq NP_417812 NC_000913.3 # RefSeq WP_000057356 NZ_LN832404.1 # SIMILARITY Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. {ECO 0000305}. # SIMILARITY Contains 1 AB hydrolase-1 (Alpha/Beta hydrolase fold 1) domain. {ECO 0000255}. # SUPFAM SSF53474 SSF53474 # eggNOG COG0429 LUCA # eggNOG ENOG4105DNZ Bacteria BLAST swissprot:YHET_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHET_ECOLI BioCyc ECOL316407:JW3316-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3316-MONOMER BioCyc EcoCyc:G7718-MONOMER http://biocyc.org/getid?id=EcoCyc:G7718-MONOMER COG COG0429 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0429 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.1.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 3.1.1.- http://enzyme.expasy.org/EC/3.1.1.- EchoBASE EB2741 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2741 EcoGene EG12904 http://www.ecogene.org/geneInfo.php?eg_id=EG12904 EnsemblBacteria AAC76378 http://www.ensemblgenomes.org/id/AAC76378 EnsemblBacteria AAC76378 http://www.ensemblgenomes.org/id/AAC76378 EnsemblBacteria BAE77937 http://www.ensemblgenomes.org/id/BAE77937 EnsemblBacteria BAE77937 http://www.ensemblgenomes.org/id/BAE77937 EnsemblBacteria BAE77937 http://www.ensemblgenomes.org/id/BAE77937 EnsemblBacteria b3353 http://www.ensemblgenomes.org/id/b3353 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0050526 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050526 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 Gene3D 3.40.50.1820 http://www.cathdb.info/version/latest/superfamily/3.40.50.1820 GeneID 947855 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947855 HOGENOM HOG000264008 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000264008&db=HOGENOM6 InParanoid P45524 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45524 IntAct P45524 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45524* IntEnz 3.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.1 InterPro IPR000073 http://www.ebi.ac.uk/interpro/entry/IPR000073 InterPro IPR000952 http://www.ebi.ac.uk/interpro/entry/IPR000952 InterPro IPR012020 http://www.ebi.ac.uk/interpro/entry/IPR012020 InterPro IPR029058 http://www.ebi.ac.uk/interpro/entry/IPR029058 KEGG_Gene ecj:JW3316 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3316 KEGG_Gene eco:b3353 http://www.genome.jp/dbget-bin/www_bget?eco:b3353 KEGG_Orthology KO:K07019 http://www.genome.jp/dbget-bin/www_bget?KO:K07019 OMA HLQTLWG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HLQTLWG PROSITE PS01133 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01133 PSORT swissprot:YHET_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHET_ECOLI PSORT-B swissprot:YHET_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHET_ECOLI PSORT2 swissprot:YHET_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHET_ECOLI Pfam PF00561 http://pfam.xfam.org/family/PF00561 Phobius swissprot:YHET_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHET_ECOLI PhylomeDB P45524 http://phylomedb.org/?seqid=P45524 ProteinModelPortal P45524 http://www.proteinmodelportal.org/query/uniprot/P45524 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417812 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417812 RefSeq WP_000057356 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000057356 STRING 511145.b3353 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3353&targetmode=cogs STRING COG0429 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0429&targetmode=cogs SUPFAM SSF53474 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53474 UniProtKB YHET_ECOLI http://www.uniprot.org/uniprot/YHET_ECOLI UniProtKB-AC P45524 http://www.uniprot.org/uniprot/P45524 charge swissprot:YHET_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHET_ECOLI eggNOG COG0429 http://eggnogapi.embl.de/nog_data/html/tree/COG0429 eggNOG ENOG4105DNZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DNZ epestfind swissprot:YHET_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHET_ECOLI garnier swissprot:YHET_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHET_ECOLI helixturnhelix swissprot:YHET_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHET_ECOLI hmoment swissprot:YHET_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHET_ECOLI iep swissprot:YHET_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHET_ECOLI inforesidue swissprot:YHET_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHET_ECOLI octanol swissprot:YHET_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHET_ECOLI pepcoil swissprot:YHET_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHET_ECOLI pepdigest swissprot:YHET_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHET_ECOLI pepinfo swissprot:YHET_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHET_ECOLI pepnet swissprot:YHET_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHET_ECOLI pepstats swissprot:YHET_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHET_ECOLI pepwheel swissprot:YHET_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHET_ECOLI pepwindow swissprot:YHET_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHET_ECOLI sigcleave swissprot:YHET_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHET_ECOLI ## Database ID URL or Descriptions # BioGrid 4261620 10 # CDD cd07377 WHTH_GntR # EcoGene EG12579 yjiR # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_function GO:0008483 transaminase activity; IEA:UniProtKB-KW. # GO_function GO:0030170 pyridoxal phosphate binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; ISS:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # Gene3D 3.40.640.10 -; 1. # Gene3D 3.90.1150.10 -; 1. # IntAct P39389 4 # InterPro IPR000524 Tscrpt_reg_HTH_GntR # InterPro IPR004839 Aminotransferase_I/II # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR015421 PyrdxlP-dep_Trfase_major_sub1 # InterPro IPR015422 PyrdxlP-dep_Trfase_major_sub2 # InterPro IPR015424 PyrdxlP-dep_Trfase # Organism YJIR_ECOLI Escherichia coli (strain K12) # PATRIC 32124288 VBIEscCol129921_4487 # PIR S56565 S56565 # PROSITE PS50949 HTH_GNTR # Pfam PF00155 Aminotran_1_2 # Pfam PF00392 GntR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJIR_ECOLI Uncharacterized HTH-type transcriptional regulator YjiR # RefSeq NP_418760 NC_000913.3 # RefSeq WP_000199300 NZ_LN832404.1 # SIMILARITY Contains 1 HTH gntR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00307}. # SIMILARITY In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. {ECO 0000305}. # SMART SM00345 HTH_GNTR # SUPFAM SSF46785 SSF46785 # SUPFAM SSF53383 SSF53383 # eggNOG COG1167 LUCA # eggNOG ENOG4105C1I Bacteria BLAST swissprot:YJIR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJIR_ECOLI BioCyc ECOL316407:JW4303-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4303-MONOMER BioCyc EcoCyc:G7936-MONOMER http://biocyc.org/getid?id=EcoCyc:G7936-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2466 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2466 EcoGene EG12579 http://www.ecogene.org/geneInfo.php?eg_id=EG12579 EnsemblBacteria AAC77296 http://www.ensemblgenomes.org/id/AAC77296 EnsemblBacteria AAC77296 http://www.ensemblgenomes.org/id/AAC77296 EnsemblBacteria BAE78332 http://www.ensemblgenomes.org/id/BAE78332 EnsemblBacteria BAE78332 http://www.ensemblgenomes.org/id/BAE78332 EnsemblBacteria BAE78332 http://www.ensemblgenomes.org/id/BAE78332 EnsemblBacteria b4340 http://www.ensemblgenomes.org/id/b4340 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0008483 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008483 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 3.40.640.10 http://www.cathdb.info/version/latest/superfamily/3.40.640.10 Gene3D 3.90.1150.10 http://www.cathdb.info/version/latest/superfamily/3.90.1150.10 GeneID 949089 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949089 HOGENOM HOG000133006 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000133006&db=HOGENOM6 InParanoid P39389 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39389 IntAct P39389 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39389* InterPro IPR000524 http://www.ebi.ac.uk/interpro/entry/IPR000524 InterPro IPR004839 http://www.ebi.ac.uk/interpro/entry/IPR004839 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR015421 http://www.ebi.ac.uk/interpro/entry/IPR015421 InterPro IPR015422 http://www.ebi.ac.uk/interpro/entry/IPR015422 InterPro IPR015424 http://www.ebi.ac.uk/interpro/entry/IPR015424 KEGG_Gene ecj:JW4303 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4303 KEGG_Gene eco:b4340 http://www.genome.jp/dbget-bin/www_bget?eco:b4340 OMA DMPGLYY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DMPGLYY PROSITE PS50949 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50949 PSORT swissprot:YJIR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJIR_ECOLI PSORT-B swissprot:YJIR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJIR_ECOLI PSORT2 swissprot:YJIR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJIR_ECOLI Pfam PF00155 http://pfam.xfam.org/family/PF00155 Pfam PF00392 http://pfam.xfam.org/family/PF00392 Phobius swissprot:YJIR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJIR_ECOLI PhylomeDB P39389 http://phylomedb.org/?seqid=P39389 ProteinModelPortal P39389 http://www.proteinmodelportal.org/query/uniprot/P39389 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418760 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418760 RefSeq WP_000199300 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000199300 SMART SM00345 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00345 SMR P39389 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39389 STRING 511145.b4340 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4340&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SUPFAM SSF53383 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53383 UniProtKB YJIR_ECOLI http://www.uniprot.org/uniprot/YJIR_ECOLI UniProtKB-AC P39389 http://www.uniprot.org/uniprot/P39389 charge swissprot:YJIR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJIR_ECOLI eggNOG COG1167 http://eggnogapi.embl.de/nog_data/html/tree/COG1167 eggNOG ENOG4105C1I http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C1I epestfind swissprot:YJIR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJIR_ECOLI garnier swissprot:YJIR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJIR_ECOLI helixturnhelix swissprot:YJIR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJIR_ECOLI hmoment swissprot:YJIR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJIR_ECOLI iep swissprot:YJIR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJIR_ECOLI inforesidue swissprot:YJIR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJIR_ECOLI octanol swissprot:YJIR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJIR_ECOLI pepcoil swissprot:YJIR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJIR_ECOLI pepdigest swissprot:YJIR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJIR_ECOLI pepinfo swissprot:YJIR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJIR_ECOLI pepnet swissprot:YJIR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJIR_ECOLI pepstats swissprot:YJIR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJIR_ECOLI pepwheel swissprot:YJIR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJIR_ECOLI pepwindow swissprot:YJIR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJIR_ECOLI sigcleave swissprot:YJIR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJIR_ECOLI ## Database ID URL or Descriptions # EcoGene EG11346 fliE # GO_component GO:0009425 bacterial-type flagellum basal body; IEA:UniProtKB-SubCell. # GO_function GO:0003774 motor activity; IEA:InterPro. # GO_function GO:0005198 structural molecule activity; IEA:InterPro. # GO_process GO:0071973 bacterial-type flagellum-dependent cell motility; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0005198 structural molecule activity # GOslim_process GO:0048870 cell motility # HAMAP MF_00724 FliE # IntAct P0A8T5 2 # InterPro IPR001624 FliE # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Pathway ko02040 Flagellar assembly # Organism FLIE_ECOLI Escherichia coli (strain K12) # PATRIC 32119203 VBIEscCol129921_2016 # PIR A42376 A42376 # PRINTS PR01006 FLGHOOKFLIE # Pfam PF02049 FliE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FLIE_ECOLI Flagellar hook-basal body complex protein FliE # RefSeq NP_416447 NC_000913.3 # RefSeq WP_001274299 NZ_LN832404.1 # SIMILARITY Belongs to the FliE family. {ECO 0000305}. # SUBCELLULAR LOCATION FLIE_ECOLI Bacterial flagellum basal body {ECO 0000250}. # TIGRFAMs TIGR00205 fliE # eggNOG COG1677 LUCA # eggNOG ENOG4105VQ0 Bacteria BLAST swissprot:FLIE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLIE_ECOLI BioCyc ECOL316407:JW1921-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1921-MONOMER BioCyc EcoCyc:EG11346-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11346-MONOMER COG COG1677 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1677 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1099/00221287-139-7-1401 http://dx.doi.org/10.1099/00221287-139-7-1401 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L13279 http://www.ebi.ac.uk/ena/data/view/L13279 EMBL M84992 http://www.ebi.ac.uk/ena/data/view/M84992 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1322 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1322 EcoGene EG11346 http://www.ecogene.org/geneInfo.php?eg_id=EG11346 EnsemblBacteria AAC75004 http://www.ensemblgenomes.org/id/AAC75004 EnsemblBacteria AAC75004 http://www.ensemblgenomes.org/id/AAC75004 EnsemblBacteria BAA15760 http://www.ensemblgenomes.org/id/BAA15760 EnsemblBacteria BAA15760 http://www.ensemblgenomes.org/id/BAA15760 EnsemblBacteria BAA15760 http://www.ensemblgenomes.org/id/BAA15760 EnsemblBacteria b1937 http://www.ensemblgenomes.org/id/b1937 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009425 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009425 GO_function GO:0003774 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003774 GO_function GO:0005198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005198 GO_process GO:0071973 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071973 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0005198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005198 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 GeneID 946446 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946446 HAMAP MF_00724 http://hamap.expasy.org/unirule/MF_00724 HOGENOM HOG000265837 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000265837&db=HOGENOM6 InParanoid P0A8T5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8T5 IntAct P0A8T5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8T5* InterPro IPR001624 http://www.ebi.ac.uk/interpro/entry/IPR001624 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW1921 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1921 KEGG_Gene eco:b1937 http://www.genome.jp/dbget-bin/www_bget?eco:b1937 KEGG_Orthology KO:K02408 http://www.genome.jp/dbget-bin/www_bget?KO:K02408 KEGG_Pathway ko02040 http://www.genome.jp/kegg-bin/show_pathway?ko02040 OMA SLEETMI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SLEETMI PRINTS PR01006 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01006 PSORT swissprot:FLIE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLIE_ECOLI PSORT-B swissprot:FLIE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLIE_ECOLI PSORT2 swissprot:FLIE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLIE_ECOLI Pfam PF02049 http://pfam.xfam.org/family/PF02049 Phobius swissprot:FLIE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLIE_ECOLI PhylomeDB P0A8T5 http://phylomedb.org/?seqid=P0A8T5 ProteinModelPortal P0A8T5 http://www.proteinmodelportal.org/query/uniprot/P0A8T5 PubMed 1551848 http://www.ncbi.nlm.nih.gov/pubmed/1551848 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8371104 http://www.ncbi.nlm.nih.gov/pubmed/8371104 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416447 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416447 RefSeq WP_001274299 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001274299 STRING 511145.b1937 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1937&targetmode=cogs STRING COG1677 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1677&targetmode=cogs TIGRFAMs TIGR00205 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00205 UniProtKB FLIE_ECOLI http://www.uniprot.org/uniprot/FLIE_ECOLI UniProtKB-AC P0A8T5 http://www.uniprot.org/uniprot/P0A8T5 charge swissprot:FLIE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLIE_ECOLI eggNOG COG1677 http://eggnogapi.embl.de/nog_data/html/tree/COG1677 eggNOG ENOG4105VQ0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VQ0 epestfind swissprot:FLIE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLIE_ECOLI garnier swissprot:FLIE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLIE_ECOLI helixturnhelix swissprot:FLIE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLIE_ECOLI hmoment swissprot:FLIE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLIE_ECOLI iep swissprot:FLIE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLIE_ECOLI inforesidue swissprot:FLIE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLIE_ECOLI octanol swissprot:FLIE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLIE_ECOLI pepcoil swissprot:FLIE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLIE_ECOLI pepdigest swissprot:FLIE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLIE_ECOLI pepinfo swissprot:FLIE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLIE_ECOLI pepnet swissprot:FLIE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLIE_ECOLI pepstats swissprot:FLIE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLIE_ECOLI pepwheel swissprot:FLIE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLIE_ECOLI pepwindow swissprot:FLIE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLIE_ECOLI sigcleave swissprot:FLIE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLIE_ECOLI ## Database ID URL or Descriptions # BioGrid 4260378 19 # EcoGene EG14035 flhB # FUNCTION FLHB_ECOLI Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0009306 protein secretion; IEA:InterPro. # GO_process GO:0044780 bacterial-type flagellum assembly; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006810 transport # GOslim_process GO:0022607 cellular component assembly # Gene3D 3.40.1690.10 -; 1. # IntAct P76299 3 # InterPro IPR006135 T3SS_substrate_exporter # InterPro IPR006136 FlhB # InterPro IPR029025 T3SS_substrate_exporter_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko02040 Flagellar assembly # Organism FLHB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30531 PTHR30531 # PATRIC 32119085 VBIEscCol129921_1960 # PIR H64950 H64950 # PRINTS PR00950 TYPE3IMSPROT # Pfam PF01312 Bac_export_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FLHB_ECOLI Flagellar biosynthetic protein FlhB # RefSeq NP_416394 NC_000913.3 # RefSeq WP_001278954 NZ_LN832404.1 # SIMILARITY Belongs to the type III secretion exporter family. {ECO 0000305}. # SUBCELLULAR LOCATION FLHB_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF160544 SSF160544 # TIGRFAMs TIGR00328 flhB # eggNOG COG1377 LUCA # eggNOG ENOG4105D00 Bacteria BLAST swissprot:FLHB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLHB_ECOLI BioCyc ECOL316407:JW1869-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1869-MONOMER BioCyc EcoCyc:G7028-MONOMER http://biocyc.org/getid?id=EcoCyc:G7028-MONOMER COG COG1377 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1377 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U88319 http://www.ebi.ac.uk/ena/data/view/U88319 EchoBASE EB3789 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3789 EcoGene EG14035 http://www.ecogene.org/geneInfo.php?eg_id=EG14035 EnsemblBacteria AAC74950 http://www.ensemblgenomes.org/id/AAC74950 EnsemblBacteria AAC74950 http://www.ensemblgenomes.org/id/AAC74950 EnsemblBacteria BAA15696 http://www.ensemblgenomes.org/id/BAA15696 EnsemblBacteria BAA15696 http://www.ensemblgenomes.org/id/BAA15696 EnsemblBacteria BAA15696 http://www.ensemblgenomes.org/id/BAA15696 EnsemblBacteria b1880 http://www.ensemblgenomes.org/id/b1880 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0009306 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009306 GO_process GO:0044780 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044780 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 Gene3D 3.40.1690.10 http://www.cathdb.info/version/latest/superfamily/3.40.1690.10 GeneID 946391 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946391 HOGENOM HOG000253899 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000253899&db=HOGENOM6 InParanoid P76299 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76299 IntAct P76299 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76299* InterPro IPR006135 http://www.ebi.ac.uk/interpro/entry/IPR006135 InterPro IPR006136 http://www.ebi.ac.uk/interpro/entry/IPR006136 InterPro IPR029025 http://www.ebi.ac.uk/interpro/entry/IPR029025 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW1869 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1869 KEGG_Gene eco:b1880 http://www.genome.jp/dbget-bin/www_bget?eco:b1880 KEGG_Orthology KO:K02401 http://www.genome.jp/dbget-bin/www_bget?KO:K02401 KEGG_Pathway ko02040 http://www.genome.jp/kegg-bin/show_pathway?ko02040 OMA NLKMSKQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NLKMSKQ PANTHER PTHR30531 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30531 PRINTS PR00950 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00950 PSORT swissprot:FLHB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLHB_ECOLI PSORT-B swissprot:FLHB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLHB_ECOLI PSORT2 swissprot:FLHB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLHB_ECOLI Pfam PF01312 http://pfam.xfam.org/family/PF01312 Phobius swissprot:FLHB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLHB_ECOLI PhylomeDB P76299 http://phylomedb.org/?seqid=P76299 ProteinModelPortal P76299 http://www.proteinmodelportal.org/query/uniprot/P76299 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416394 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416394 RefSeq WP_001278954 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001278954 SMR P76299 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76299 STRING 511145.b1880 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1880&targetmode=cogs STRING COG1377 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1377&targetmode=cogs SUPFAM SSF160544 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF160544 TIGRFAMs TIGR00328 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00328 UniProtKB FLHB_ECOLI http://www.uniprot.org/uniprot/FLHB_ECOLI UniProtKB-AC P76299 http://www.uniprot.org/uniprot/P76299 charge swissprot:FLHB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLHB_ECOLI eggNOG COG1377 http://eggnogapi.embl.de/nog_data/html/tree/COG1377 eggNOG ENOG4105D00 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D00 epestfind swissprot:FLHB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLHB_ECOLI garnier swissprot:FLHB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLHB_ECOLI helixturnhelix swissprot:FLHB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLHB_ECOLI hmoment swissprot:FLHB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLHB_ECOLI iep swissprot:FLHB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLHB_ECOLI inforesidue swissprot:FLHB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLHB_ECOLI octanol swissprot:FLHB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLHB_ECOLI pepcoil swissprot:FLHB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLHB_ECOLI pepdigest swissprot:FLHB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLHB_ECOLI pepinfo swissprot:FLHB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLHB_ECOLI pepnet swissprot:FLHB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLHB_ECOLI pepstats swissprot:FLHB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLHB_ECOLI pepwheel swissprot:FLHB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLHB_ECOLI pepwindow swissprot:FLHB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLHB_ECOLI sigcleave swissprot:FLHB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLHB_ECOLI ## Database ID URL or Descriptions # AltName DGOK_ECOLI 2-keto-3-deoxy-galactonokinase # AltName DGOK_ECOLI 2-oxo-3-deoxygalactonate kinase # BioGrid 4263413 153 # CATALYTIC ACTIVITY DGOK_ECOLI ATP + 2-dehydro-3-deoxy-D-galactonate = ADP + 2-dehydro-3-deoxy-D-galactonate 6-phosphate. # EcoGene EG11717 dgoK # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0008671 2-dehydro-3-deoxygalactonokinase activity; IDA:EcoCyc. # GO_process GO:0034194 D-galactonate catabolic process; IMP:EcoCyc. # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # IntAct P31459 3 # InterPro IPR007729 DGOK # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00052 Galactose metabolism # Organism DGOK_ECOLI Escherichia coli (strain K12) # PATHWAY Carbohydrate acid metabolism; D-galactonate degradation; D-glyceraldehyde 3-phosphate and pyruvate from D-galactonate step 2/3. # PATRIC 32122883 VBIEscCol129921_3817 # PIR F65171 F65171 # Pfam PF05035 DGOK # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DGOK_ECOLI 2-dehydro-3-deoxygalactonokinase # RefSeq NP_418148 NC_000913.3 # RefSeq WP_000127091 NZ_LN832404.1 # SIMILARITY Belongs to the DgoK family. {ECO 0000305}. # UniPathway UPA00081 UER00519 # eggNOG COG3734 LUCA # eggNOG ENOG4105EI3 Bacteria BLAST swissprot:DGOK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DGOK_ECOLI BioCyc ECOL316407:JW3670-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3670-MONOMER BioCyc EcoCyc:DEHYDDEOXGALACTKIN-MONOMER http://biocyc.org/getid?id=EcoCyc:DEHYDDEOXGALACTKIN-MONOMER BioCyc MetaCyc:DEHYDDEOXGALACTKIN-MONOMER http://biocyc.org/getid?id=MetaCyc:DEHYDDEOXGALACTKIN-MONOMER COG COG3734 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3734 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.58 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.58 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.58 http://enzyme.expasy.org/EC/2.7.1.58 EchoBASE EB1668 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1668 EcoGene EG11717 http://www.ecogene.org/geneInfo.php?eg_id=EG11717 EnsemblBacteria AAC76716 http://www.ensemblgenomes.org/id/AAC76716 EnsemblBacteria AAC76716 http://www.ensemblgenomes.org/id/AAC76716 EnsemblBacteria BAE77600 http://www.ensemblgenomes.org/id/BAE77600 EnsemblBacteria BAE77600 http://www.ensemblgenomes.org/id/BAE77600 EnsemblBacteria BAE77600 http://www.ensemblgenomes.org/id/BAE77600 EnsemblBacteria b3693 http://www.ensemblgenomes.org/id/b3693 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008671 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008671 GO_process GO:0034194 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034194 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 948207 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948207 HOGENOM HOG000256078 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000256078&db=HOGENOM6 InParanoid P31459 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31459 IntAct P31459 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31459* IntEnz 2.7.1.58 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.58 InterPro IPR007729 http://www.ebi.ac.uk/interpro/entry/IPR007729 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3670 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3670 KEGG_Gene eco:b3693 http://www.genome.jp/dbget-bin/www_bget?eco:b3693 KEGG_Orthology KO:K00883 http://www.genome.jp/dbget-bin/www_bget?KO:K00883 KEGG_Pathway ko00052 http://www.genome.jp/kegg-bin/show_pathway?ko00052 KEGG_Reaction rn:R03387 http://www.genome.jp/dbget-bin/www_bget?rn:R03387 OMA VGWKIAP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VGWKIAP PSORT swissprot:DGOK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DGOK_ECOLI PSORT-B swissprot:DGOK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DGOK_ECOLI PSORT2 swissprot:DGOK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DGOK_ECOLI Pfam PF05035 http://pfam.xfam.org/family/PF05035 Phobius swissprot:DGOK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DGOK_ECOLI PhylomeDB P31459 http://phylomedb.org/?seqid=P31459 ProteinModelPortal P31459 http://www.proteinmodelportal.org/query/uniprot/P31459 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418148 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418148 RefSeq WP_000127091 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000127091 SMR P31459 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31459 STRING 511145.b3693 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3693&targetmode=cogs STRING COG3734 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3734&targetmode=cogs UniProtKB DGOK_ECOLI http://www.uniprot.org/uniprot/DGOK_ECOLI UniProtKB-AC P31459 http://www.uniprot.org/uniprot/P31459 charge swissprot:DGOK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DGOK_ECOLI eggNOG COG3734 http://eggnogapi.embl.de/nog_data/html/tree/COG3734 eggNOG ENOG4105EI3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EI3 epestfind swissprot:DGOK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DGOK_ECOLI garnier swissprot:DGOK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DGOK_ECOLI helixturnhelix swissprot:DGOK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DGOK_ECOLI hmoment swissprot:DGOK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DGOK_ECOLI iep swissprot:DGOK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DGOK_ECOLI inforesidue swissprot:DGOK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DGOK_ECOLI octanol swissprot:DGOK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DGOK_ECOLI pepcoil swissprot:DGOK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DGOK_ECOLI pepdigest swissprot:DGOK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DGOK_ECOLI pepinfo swissprot:DGOK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DGOK_ECOLI pepnet swissprot:DGOK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DGOK_ECOLI pepstats swissprot:DGOK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DGOK_ECOLI pepwheel swissprot:DGOK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DGOK_ECOLI pepwindow swissprot:DGOK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DGOK_ECOLI sigcleave swissprot:DGOK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DGOK_ECOLI ## Database ID URL or Descriptions # AltName MAT {ECO:0000255|HAMAP-Rule MF_00086} # AltName Methionine adenosyltransferase {ECO:0000255|HAMAP-Rule MF_00086} # BIOPHYSICOCHEMICAL PROPERTIES METK_ECOLI Kinetic parameters KM=3.0 mM for Mg(2+) {ECO 0000269|PubMed 7629147}; KM=0.11 mM for ATP {ECO 0000269|PubMed 7629147}; KM=0.08 mM for L-methionine {ECO 0000269|PubMed 7629147}; # BRENDA 2.5.1 2026 # BioGrid 4260657 210 # CATALYTIC ACTIVITY METK_ECOLI ATP + L-methionine + H(2)O = phosphate + diphosphate + S-adenosyl-L-methionine. {ECO 0000255|HAMAP- Rule MF_00086, ECO 0000269|PubMed 10551856, ECO 0000269|PubMed 10660564, ECO 0000269|PubMed 6251075, ECO 0000269|PubMed 7629147, ECO 0000269|PubMed 7629176, ECO 0000269|PubMed 9753435}. # CAUTION Was originally thought to differ from MetX, which was assigned as a second AdoMet synthase before being shown to be identical to MetK. {ECO:0000305|PubMed 8231813}. # COFACTOR METK_ECOLI Name=K(+); Xref=ChEBI CHEBI 29103; Evidence={ECO 0000255|HAMAP-Rule MF_00086, ECO 0000269|PubMed 14967023, ECO 0000269|PubMed 6251075, ECO 0000269|PubMed 7629147, ECO 0000269|PubMed 8550549, ECO 0000269|PubMed 8611562}; Note=Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate. {ECO 0000244|PDB 1P7L, ECO 0000244|PDB 1RG9, ECO 0000269|PubMed 14967023, ECO 0000269|PubMed 7629147, ECO 0000269|PubMed 8550549, ECO 0000269|PubMed 8611562}; # COFACTOR METK_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_00086, ECO 0000269|PubMed 10551856, ECO 0000269|PubMed 14967023, ECO 0000269|PubMed 6251075, ECO 0000269|PubMed 8550549, ECO 0000269|PubMed 8611562}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 6251075}; Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000269|PubMed 6251075}; Note=Binds 2 divalent ions per subunit. The ions interact primarily with the substrate. {ECO 0000244|PDB 1P7L, ECO 0000244|PDB 1RG9, ECO 0000269|PubMed 14967023, ECO 0000269|PubMed 8550549, ECO 0000269|PubMed 8611562, ECO 0000305|PubMed 10551856}; # DISRUPTION PHENOTYPE Cells are resistant to methionine-analogs, such as DL-ethionine(Et). {ECO:0000269|PubMed 8231813}. # EcoGene EG10589 metK # FUNCTION METK_ECOLI Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme (PubMed 6251075, PubMed 7629147, PubMed 7629176, PubMed 9753435, PubMed 10551856, PubMed 10660564). Is essential for growth (PubMed 11952912). {ECO 0000269|PubMed 10551856, ECO 0000269|PubMed 10660564, ECO 0000269|PubMed 11952912, ECO 0000269|PubMed 6251075, ECO 0000269|PubMed 7629147, ECO 0000269|PubMed 7629176, ECO 0000269|PubMed 9753435}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0004478 methionine adenosyltransferase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0030955 potassium ion binding; IDA:EcoCyc. # GO_process GO:0006556 S-adenosylmethionine biosynthetic process; IMP:EcoCyc. # GO_process GO:0006730 one-carbon metabolic process; IEA:UniProtKB-HAMAP. # GO_process GO:0033353 S-adenosylmethionine cycle; IMP:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # HAMAP MF_00086 S_AdoMet_synth1 # INDUCTION METK_ECOLI AdoMet activates the tripolyphosphatase reaction. # INTERACTION METK_ECOLI Self; NbExp=2; IntAct=EBI-546295, EBI-546295; P0A6F5 groL; NbExp=2; IntAct=EBI-546295, EBI-543750; # IntAct P0A817 38 # InterPro IPR002133 S-AdoMet_synthetase # InterPro IPR022628 S-AdoMet_synt_N # InterPro IPR022629 S-AdoMet_synt_central # InterPro IPR022630 S-AdoMet_synt_C # InterPro IPR022631 ADOMET_SYNTHASE_CS # InterPro IPR022636 S-AdoMet_synthetase_sfam # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00270 Cysteine and methionine metabolism # MASS SPECTROMETRY Mass=41843; Mass_error=10.5; Method=Electrospray; Range=2-384; Evidence={ECO:0000269|PubMed 8550549}; # Organism METK_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11964 PTHR11964 # PATHWAY METK_ECOLI Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine step 1/1. {ECO 0000255|HAMAP-Rule MF_00086, ECO 0000269|PubMed 10551856, ECO 0000269|PubMed 10660564, ECO 0000269|PubMed 6251075, ECO 0000269|PubMed 7629147, ECO 0000269|PubMed 7629176, ECO 0000269|PubMed 9753435}. # PATRIC 32121294 VBIEscCol129921_3035 # PDB 1FUG X-ray; 3.20 A; A/B=2-384 # PDB 1MXA X-ray; 2.80 A; A=2-384 # PDB 1MXB X-ray; 2.80 A; A=2-384 # PDB 1MXC X-ray; 3.00 A; A=2-384 # PDB 1P7L X-ray; 2.50 A; A/B/C/D=2-384 # PDB 1RG9 X-ray; 2.50 A; A/B/C/D=2-384 # PDB 1XRA X-ray; 3.00 A; A=2-384 # PDB 1XRB X-ray; 3.00 A; A=2-384 # PDB 1XRC X-ray; 3.00 A; A=2-384 # PIR E65079 SYECSM # PIRSF PIRSF000497 MAT # PROSITE PS00376 ADOMET_SYNTHASE_1 # PROSITE PS00377 ADOMET_SYNTHASE_2 # Pfam PF00438 S-AdoMet_synt_N # Pfam PF02772 S-AdoMet_synt_M # Pfam PF02773 S-AdoMet_synt_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName S-adenosylmethionine synthase {ECO:0000255|HAMAP-Rule MF_00086} # RefSeq NP_417417 NC_000913.3 # RefSeq WP_001062128 NZ_LN832404.1 # SIMILARITY Belongs to the AdoMet synthase family. {ECO:0000255|HAMAP-Rule MF_00086}. # SUBCELLULAR LOCATION METK_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00086}. # SUBUNIT METK_ECOLI Homotetramer; dimer of dimers (PubMed 6251075, PubMed 7629147, PubMed 7629176, PubMed 10660564, PubMed 8550549, PubMed 8611562, PubMed 8723769, PubMed 14967023). The active sites are at the interface between subunits; each dimer has two active sites (PubMed 8550549, PubMed 8611562, PubMed 8723769, PubMed 14967023). {ECO 0000269|PubMed 10660564, ECO 0000269|PubMed 14967023, ECO 0000269|PubMed 6251075, ECO 0000269|PubMed 7629176, ECO 0000269|PubMed 8550549, ECO 0000269|PubMed 8611562, ECO 0000269|PubMed 8723769}. # SUPFAM SSF55973 SSF55973; 3 # TIGRFAMs TIGR01034 metK # UniPathway UPA00315 UER00080 # eggNOG COG0192 LUCA # eggNOG ENOG4105CPH Bacteria BLAST swissprot:METK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:METK_ECOLI BioCyc ECOL316407:JW2909-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2909-MONOMER BioCyc EcoCyc:S-ADENMETSYN-MONOMER http://biocyc.org/getid?id=EcoCyc:S-ADENMETSYN-MONOMER BioCyc MetaCyc:S-ADENMETSYN-MONOMER http://biocyc.org/getid?id=MetaCyc:S-ADENMETSYN-MONOMER COG COG0192 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0192 COG COG1812 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1812 DIP DIP-35672N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35672N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1021/bi035611t http://dx.doi.org/10.1021/bi035611t DOI 10.1021/bi952604z http://dx.doi.org/10.1021/bi952604z DOI 10.1021/bi9811011 http://dx.doi.org/10.1021/bi9811011 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2002.02856.x http://dx.doi.org/10.1046/j.1365-2958.2002.02856.x DOI 10.1074/jbc.270.31.18277 http://dx.doi.org/10.1074/jbc.270.31.18277 DOI 10.1074/jbc.270.31.18484 http://dx.doi.org/10.1074/jbc.270.31.18484 DOI 10.1074/jbc.271.1.136 http://dx.doi.org/10.1074/jbc.271.1.136 DOI 10.1074/jbc.274.46.32909 http://dx.doi.org/10.1074/jbc.274.46.32909 DOI 10.1074/jbc.275.6.4060 http://dx.doi.org/10.1074/jbc.275.6.4060 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1080/07391102.1996.10508887 http://dx.doi.org/10.1080/07391102.1996.10508887 DOI 10.1111/j.1365-2958.1993.tb01742.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb01742.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.5.1.6 {ECO:0000255|HAMAP-Rule:MF_00086, ECO:0000269|PubMed:10551856, ECO:0000269|PubMed:10660564, ECO:0000269|PubMed:6251075, ECO:0000269|PubMed:7629147, ECO:0000269|PubMed:7629176, ECO:0000269|PubMed:9753435} http://www.genome.jp/dbget-bin/www_bget?EC:2.5.1.6 {ECO:0000255|HAMAP-Rule:MF_00086, ECO:0000269|PubMed:10551856, ECO:0000269|PubMed:10660564, ECO:0000269|PubMed:6251075, ECO:0000269|PubMed:7629147, ECO:0000269|PubMed:7629176, ECO:0000269|PubMed:9753435} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K02129 http://www.ebi.ac.uk/ena/data/view/K02129 EMBL M31770 http://www.ebi.ac.uk/ena/data/view/M31770 EMBL M98266 http://www.ebi.ac.uk/ena/data/view/M98266 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 ENZYME 2.5.1.6 {ECO:0000255|HAMAP-Rule:MF_00086, ECO:0000269|PubMed:10551856, ECO:0000269|PubMed:10660564, ECO:0000269|PubMed:6251075, ECO:0000269|PubMed:7629147, ECO:0000269|PubMed:7629176, ECO:0000269|PubMed:9753435} http://enzyme.expasy.org/EC/2.5.1.6 {ECO:0000255|HAMAP-Rule:MF_00086, ECO:0000269|PubMed:10551856, ECO:0000269|PubMed:10660564, ECO:0000269|PubMed:6251075, ECO:0000269|PubMed:7629147, ECO:0000269|PubMed:7629176, ECO:0000269|PubMed:9753435} EchoBASE EB0584 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0584 EcoGene EG10589 http://www.ecogene.org/geneInfo.php?eg_id=EG10589 EnsemblBacteria AAC75979 http://www.ensemblgenomes.org/id/AAC75979 EnsemblBacteria AAC75979 http://www.ensemblgenomes.org/id/AAC75979 EnsemblBacteria BAE77005 http://www.ensemblgenomes.org/id/BAE77005 EnsemblBacteria BAE77005 http://www.ensemblgenomes.org/id/BAE77005 EnsemblBacteria BAE77005 http://www.ensemblgenomes.org/id/BAE77005 EnsemblBacteria b2942 http://www.ensemblgenomes.org/id/b2942 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0004478 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004478 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0030955 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030955 GO_process GO:0006556 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006556 GO_process GO:0006730 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006730 GO_process GO:0033353 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033353 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016765 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GeneID 945389 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945389 HAMAP MF_00086 http://hamap.expasy.org/unirule/MF_00086 HOGENOM HOG000245710 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000245710&db=HOGENOM6 InParanoid P0A817 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A817 IntAct P0A817 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A817* IntEnz 2.5.1.6 {ECO:0000255|HAMAP-Rule:MF_00086, ECO:0000269|PubMed:10551856, ECO:0000269|PubMed:10660564, ECO:0000269|PubMed:6251075, ECO:0000269|PubMed:7629147, ECO:0000269|PubMed:7629176, ECO:0000269|PubMed:9753435} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.5.1.6 {ECO:0000255|HAMAP-Rule:MF_00086, ECO:0000269|PubMed:10551856, ECO:0000269|PubMed:10660564, ECO:0000269|PubMed:6251075, ECO:0000269|PubMed:7629147, ECO:0000269|PubMed:7629176, ECO:0000269|PubMed:9753435} InterPro IPR002133 http://www.ebi.ac.uk/interpro/entry/IPR002133 InterPro IPR022628 http://www.ebi.ac.uk/interpro/entry/IPR022628 InterPro IPR022629 http://www.ebi.ac.uk/interpro/entry/IPR022629 InterPro IPR022630 http://www.ebi.ac.uk/interpro/entry/IPR022630 InterPro IPR022631 http://www.ebi.ac.uk/interpro/entry/IPR022631 InterPro IPR022636 http://www.ebi.ac.uk/interpro/entry/IPR022636 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2909 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2909 KEGG_Gene eco:b2942 http://www.genome.jp/dbget-bin/www_bget?eco:b2942 KEGG_Orthology KO:K00789 http://www.genome.jp/dbget-bin/www_bget?KO:K00789 KEGG_Pathway ko00270 http://www.genome.jp/kegg-bin/show_pathway?ko00270 KEGG_Reaction rn:R00177 http://www.genome.jp/dbget-bin/www_bget?rn:R00177 KEGG_Reaction rn:R04771 http://www.genome.jp/dbget-bin/www_bget?rn:R04771 MINT MINT-1233798 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1233798 OMA DNFLAFD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DNFLAFD PANTHER PTHR11964 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11964 PDB 1FUG http://www.ebi.ac.uk/pdbe-srv/view/entry/1FUG PDB 1MXA http://www.ebi.ac.uk/pdbe-srv/view/entry/1MXA PDB 1MXB http://www.ebi.ac.uk/pdbe-srv/view/entry/1MXB PDB 1MXC http://www.ebi.ac.uk/pdbe-srv/view/entry/1MXC PDB 1P7L http://www.ebi.ac.uk/pdbe-srv/view/entry/1P7L PDB 1RG9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1RG9 PDB 1XRA http://www.ebi.ac.uk/pdbe-srv/view/entry/1XRA PDB 1XRB http://www.ebi.ac.uk/pdbe-srv/view/entry/1XRB PDB 1XRC http://www.ebi.ac.uk/pdbe-srv/view/entry/1XRC PDBsum 1FUG http://www.ebi.ac.uk/pdbsum/1FUG PDBsum 1MXA http://www.ebi.ac.uk/pdbsum/1MXA PDBsum 1MXB http://www.ebi.ac.uk/pdbsum/1MXB PDBsum 1MXC http://www.ebi.ac.uk/pdbsum/1MXC PDBsum 1P7L http://www.ebi.ac.uk/pdbsum/1P7L PDBsum 1RG9 http://www.ebi.ac.uk/pdbsum/1RG9 PDBsum 1XRA http://www.ebi.ac.uk/pdbsum/1XRA PDBsum 1XRB http://www.ebi.ac.uk/pdbsum/1XRB PDBsum 1XRC http://www.ebi.ac.uk/pdbsum/1XRC PROSITE PS00376 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00376 PROSITE PS00377 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00377 PSORT swissprot:METK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:METK_ECOLI PSORT-B swissprot:METK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:METK_ECOLI PSORT2 swissprot:METK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:METK_ECOLI Pfam PF00438 http://pfam.xfam.org/family/PF00438 Pfam PF02772 http://pfam.xfam.org/family/PF02772 Pfam PF02773 http://pfam.xfam.org/family/PF02773 Phobius swissprot:METK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:METK_ECOLI PhylomeDB P0A817 http://phylomedb.org/?seqid=P0A817 ProteinModelPortal P0A817 http://www.proteinmodelportal.org/query/uniprot/P0A817 PubMed 10551856 http://www.ncbi.nlm.nih.gov/pubmed/10551856 PubMed 10660564 http://www.ncbi.nlm.nih.gov/pubmed/10660564 PubMed 11952912 http://www.ncbi.nlm.nih.gov/pubmed/11952912 PubMed 14967023 http://www.ncbi.nlm.nih.gov/pubmed/14967023 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 2198270 http://www.ncbi.nlm.nih.gov/pubmed/2198270 PubMed 6094561 http://www.ncbi.nlm.nih.gov/pubmed/6094561 PubMed 6251075 http://www.ncbi.nlm.nih.gov/pubmed/6251075 PubMed 7629147 http://www.ncbi.nlm.nih.gov/pubmed/7629147 PubMed 7629176 http://www.ncbi.nlm.nih.gov/pubmed/7629176 PubMed 8231813 http://www.ncbi.nlm.nih.gov/pubmed/8231813 PubMed 8550549 http://www.ncbi.nlm.nih.gov/pubmed/8550549 PubMed 8611562 http://www.ncbi.nlm.nih.gov/pubmed/8611562 PubMed 8723769 http://www.ncbi.nlm.nih.gov/pubmed/8723769 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9753435 http://www.ncbi.nlm.nih.gov/pubmed/9753435 RefSeq NP_417417 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417417 RefSeq WP_001062128 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001062128 SMR P0A817 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A817 STRING 511145.b2942 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2942&targetmode=cogs STRING COG0192 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0192&targetmode=cogs STRING COG1812 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1812&targetmode=cogs SUPFAM SSF55973 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55973 SWISS-2DPAGE P0A817 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A817 TIGRFAMs TIGR01034 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01034 UniProtKB METK_ECOLI http://www.uniprot.org/uniprot/METK_ECOLI UniProtKB-AC P0A817 http://www.uniprot.org/uniprot/P0A817 charge swissprot:METK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:METK_ECOLI eggNOG COG0192 http://eggnogapi.embl.de/nog_data/html/tree/COG0192 eggNOG ENOG4105CPH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CPH epestfind swissprot:METK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:METK_ECOLI garnier swissprot:METK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:METK_ECOLI helixturnhelix swissprot:METK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:METK_ECOLI hmoment swissprot:METK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:METK_ECOLI iep swissprot:METK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:METK_ECOLI inforesidue swissprot:METK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:METK_ECOLI octanol swissprot:METK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:METK_ECOLI pepcoil swissprot:METK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:METK_ECOLI pepdigest swissprot:METK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:METK_ECOLI pepinfo swissprot:METK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:METK_ECOLI pepnet swissprot:METK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:METK_ECOLI pepstats swissprot:METK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:METK_ECOLI pepwheel swissprot:METK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:METK_ECOLI pepwindow swissprot:METK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:METK_ECOLI sigcleave swissprot:METK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:METK_ECOLI ## Database ID URL or Descriptions # BioGrid 4260336 198 # DISRUPTION PHENOTYPE Deletion of yeaV has no effect on the aerobic growth with D-malate as the sole carbon source. {ECO:0000269|PubMed 20233924}. # EcoGene EG13508 yeaV # FUNCTION YEAV_ECOLI Probable transporter whose substrate is unknown. Is not involved in aerobic D-malate transport. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015077 monovalent inorganic cation transmembrane transporter activity; IBA:GO_Central. # GO_process GO:0071705 nitrogen compound transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR000060 BCCT_transptr # InterPro IPR018093 BCCT_CS # Organism YEAV_ECOLI Escherichia coli (strain K12) # PATRIC 32118919 VBIEscCol129921_1877 # PIR A64941 A64941 # PROSITE PS01303 BCCT # Pfam PF02028 BCCT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEAV_ECOLI Uncharacterized transporter YeaV # RefSeq NP_416315 NC_000913.3 # SIMILARITY Belongs to the BCCT transporter (TC 2.A.15) family. {ECO 0000305}. # SUBCELLULAR LOCATION YEAV_ECOLI Cell inner membrane {ECO 0000305}; Multi- pass membrane protein {ECO 0000305}. # TIGRFAMs TIGR00842 bcct # eggNOG COG1292 LUCA # eggNOG ENOG4105C94 Bacteria BLAST swissprot:YEAV_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEAV_ECOLI BioCyc ECOL316407:JW5293-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5293-MONOMER BioCyc EcoCyc:YEAV-MONOMER http://biocyc.org/getid?id=EcoCyc:YEAV-MONOMER COG COG1292 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1292 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01665-09 http://dx.doi.org/10.1128/JB.01665-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3281 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3281 EcoGene EG13508 http://www.ecogene.org/geneInfo.php?eg_id=EG13508 EnsemblBacteria AAC74871 http://www.ensemblgenomes.org/id/AAC74871 EnsemblBacteria AAC74871 http://www.ensemblgenomes.org/id/AAC74871 EnsemblBacteria BAA15596 http://www.ensemblgenomes.org/id/BAA15596 EnsemblBacteria BAA15596 http://www.ensemblgenomes.org/id/BAA15596 EnsemblBacteria BAA15596 http://www.ensemblgenomes.org/id/BAA15596 EnsemblBacteria b1801 http://www.ensemblgenomes.org/id/b1801 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015077 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015077 GO_process GO:0071705 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071705 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 947326 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947326 HOGENOM HOG000053240 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000053240&db=HOGENOM6 InParanoid P0ABD1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABD1 InterPro IPR000060 http://www.ebi.ac.uk/interpro/entry/IPR000060 InterPro IPR018093 http://www.ebi.ac.uk/interpro/entry/IPR018093 KEGG_Gene ecj:JW5293 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5293 KEGG_Gene eco:b1801 http://www.genome.jp/dbget-bin/www_bget?eco:b1801 KEGG_Orthology KO:K03451 http://www.genome.jp/dbget-bin/www_bget?KO:K03451 OMA GFIRWIK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GFIRWIK PROSITE PS01303 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01303 PSORT swissprot:YEAV_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEAV_ECOLI PSORT-B swissprot:YEAV_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEAV_ECOLI PSORT2 swissprot:YEAV_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEAV_ECOLI Pfam PF02028 http://pfam.xfam.org/family/PF02028 Phobius swissprot:YEAV_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEAV_ECOLI PhylomeDB P0ABD1 http://phylomedb.org/?seqid=P0ABD1 ProteinModelPortal P0ABD1 http://www.proteinmodelportal.org/query/uniprot/P0ABD1 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20233924 http://www.ncbi.nlm.nih.gov/pubmed/20233924 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416315 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416315 SMR P0ABD1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABD1 STRING 511145.b1801 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1801&targetmode=cogs STRING COG1292 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1292&targetmode=cogs TIGRFAMs TIGR00842 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00842 UniProtKB YEAV_ECOLI http://www.uniprot.org/uniprot/YEAV_ECOLI UniProtKB-AC P0ABD1 http://www.uniprot.org/uniprot/P0ABD1 charge swissprot:YEAV_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEAV_ECOLI eggNOG COG1292 http://eggnogapi.embl.de/nog_data/html/tree/COG1292 eggNOG ENOG4105C94 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C94 epestfind swissprot:YEAV_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEAV_ECOLI garnier swissprot:YEAV_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEAV_ECOLI helixturnhelix swissprot:YEAV_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEAV_ECOLI hmoment swissprot:YEAV_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEAV_ECOLI iep swissprot:YEAV_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEAV_ECOLI inforesidue swissprot:YEAV_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEAV_ECOLI octanol swissprot:YEAV_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEAV_ECOLI pepcoil swissprot:YEAV_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEAV_ECOLI pepdigest swissprot:YEAV_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEAV_ECOLI pepinfo swissprot:YEAV_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEAV_ECOLI pepnet swissprot:YEAV_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEAV_ECOLI pepstats swissprot:YEAV_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEAV_ECOLI pepwheel swissprot:YEAV_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEAV_ECOLI pepwindow swissprot:YEAV_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEAV_ECOLI sigcleave swissprot:YEAV_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEAV_ECOLI ## Database ID URL or Descriptions # BioGrid 4262319 6 # CATALYTIC ACTIVITY XDHA_ECOLI Hypoxanthine + NAD(+) + H(2)O = xanthine + NADH. # CATALYTIC ACTIVITY XDHA_ECOLI Xanthine + NAD(+) + H(2)O = urate + NADH. # COFACTOR XDHA_ECOLI Name=Mo-molybdopterin; Xref=ChEBI CHEBI 71302; Evidence={ECO 0000250}; Note=Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit. {ECO 0000250}; # EcoGene EG13049 xdhA # FUNCTION XDHA_ECOLI Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism). Deletion results in increased adenine sensitivity, suggesting that this protein contributes to the conversion of adenine to guanine nucleotides during purine salvage. {ECO 0000269|PubMed 10986234}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0004854 xanthine dehydrogenase activity; IEA:UniProtKB-EC. # GO_function GO:0016491 oxidoreductase activity; IMP:EcoliWiki. # GO_function GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors; IBA:GO_Central. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0050660 flavin adenine dinucleotide binding; IBA:GO_Central. # GO_process GO:0006166 purine ribonucleoside salvage; IEA:UniProtKB-KW. # GO_process GO:0009114 hypoxanthine catabolic process; IEA:UniProtKB-UniPathway. # GO_process GO:0009115 xanthine catabolic process; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.30.365.10 -; 6. # Gene3D 3.90.1170.50 -; 1. # INDUCTION XDHA_ECOLI Is not solely regulated by nitrogen limitation. # InterPro IPR000674 Ald_Oxase/Xan_DH_a/b # InterPro IPR008274 AldOxase/xan_DH_Mopterin-bd # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # Organism XDHA_ECOLI Escherichia coli (strain K12) # PATHWAY Purine metabolism; hypoxanthine degradation; urate from hypoxanthine step 1/2. # PATHWAY Purine metabolism; hypoxanthine degradation; urate from hypoxanthine step 2/2. # PATRIC 32121142 VBIEscCol129921_2959 # PIR B65070 B65070 # Pfam PF01315 Ald_Xan_dh_C # Pfam PF02738 Ald_Xan_dh_C2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName XDHA_ECOLI Xanthine dehydrogenase molybdenum-binding subunit # RefSeq NP_417342 NC_000913.3 # SIMILARITY Belongs to the xanthine dehydrogenase family. {ECO 0000305}. # SMART SM01008 Ald_Xan_dh_C # SUBUNIT Heterotrimer of XdhA, XdhB and XdhC. {ECO 0000305}. # SUPFAM SSF54665 SSF54665 # SUPFAM SSF56003 SSF56003 # UniPathway UPA00604 UER00661 # UniPathway UPA00604 UER00662 # eggNOG COG1529 LUCA # eggNOG ENOG4105C7W Bacteria BLAST swissprot:XDHA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:XDHA_ECOLI BioCyc ECOL316407:JW5462-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5462-MONOMER BioCyc EcoCyc:G7485-MONOMER http://biocyc.org/getid?id=EcoCyc:G7485-MONOMER BioCyc MetaCyc:G7485-MONOMER http://biocyc.org/getid?id=MetaCyc:G7485-MONOMER COG COG1529 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1529 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.19.5332-5341.2000 http://dx.doi.org/10.1128/JB.182.19.5332-5341.2000 EC_number EC:1.17.1.4 http://www.genome.jp/dbget-bin/www_bget?EC:1.17.1.4 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 ENZYME 1.17.1.4 http://enzyme.expasy.org/EC/1.17.1.4 EchoBASE EB2861 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2861 EcoGene EG13049 http://www.ecogene.org/geneInfo.php?eg_id=EG13049 EnsemblBacteria AAC75904 http://www.ensemblgenomes.org/id/AAC75904 EnsemblBacteria AAC75904 http://www.ensemblgenomes.org/id/AAC75904 EnsemblBacteria BAE76932 http://www.ensemblgenomes.org/id/BAE76932 EnsemblBacteria BAE76932 http://www.ensemblgenomes.org/id/BAE76932 EnsemblBacteria BAE76932 http://www.ensemblgenomes.org/id/BAE76932 EnsemblBacteria b2866 http://www.ensemblgenomes.org/id/b2866 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004854 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004854 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0016903 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016903 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_process GO:0006166 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006166 GO_process GO:0009114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009114 GO_process GO:0009115 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009115 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.30.365.10 http://www.cathdb.info/version/latest/superfamily/3.30.365.10 Gene3D 3.90.1170.50 http://www.cathdb.info/version/latest/superfamily/3.90.1170.50 GeneID 947116 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947116 HOGENOM HOG000244715 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000244715&db=HOGENOM6 InParanoid Q46799 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46799 IntAct Q46799 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46799* IntEnz 1.17.1.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.17.1.4 InterPro IPR000674 http://www.ebi.ac.uk/interpro/entry/IPR000674 InterPro IPR008274 http://www.ebi.ac.uk/interpro/entry/IPR008274 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5462 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5462 KEGG_Gene eco:b2866 http://www.genome.jp/dbget-bin/www_bget?eco:b2866 KEGG_Orthology KO:K00087 http://www.genome.jp/dbget-bin/www_bget?KO:K00087 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Reaction rn:R01768 http://www.genome.jp/dbget-bin/www_bget?rn:R01768 KEGG_Reaction rn:R02103 http://www.genome.jp/dbget-bin/www_bget?rn:R02103 OMA AYVSHGH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AYVSHGH PSORT swissprot:XDHA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:XDHA_ECOLI PSORT-B swissprot:XDHA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:XDHA_ECOLI PSORT2 swissprot:XDHA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:XDHA_ECOLI Pfam PF01315 http://pfam.xfam.org/family/PF01315 Pfam PF02738 http://pfam.xfam.org/family/PF02738 Phobius swissprot:XDHA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:XDHA_ECOLI PhylomeDB Q46799 http://phylomedb.org/?seqid=Q46799 ProteinModelPortal Q46799 http://www.proteinmodelportal.org/query/uniprot/Q46799 PubMed 10986234 http://www.ncbi.nlm.nih.gov/pubmed/10986234 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417342 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417342 SMART SM01008 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01008 SMR Q46799 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46799 STRING 511145.b2866 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2866&targetmode=cogs STRING COG1529 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1529&targetmode=cogs SUPFAM SSF54665 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54665 SUPFAM SSF56003 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56003 UniProtKB XDHA_ECOLI http://www.uniprot.org/uniprot/XDHA_ECOLI UniProtKB-AC Q46799 http://www.uniprot.org/uniprot/Q46799 charge swissprot:XDHA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:XDHA_ECOLI eggNOG COG1529 http://eggnogapi.embl.de/nog_data/html/tree/COG1529 eggNOG ENOG4105C7W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C7W epestfind swissprot:XDHA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:XDHA_ECOLI garnier swissprot:XDHA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:XDHA_ECOLI helixturnhelix swissprot:XDHA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:XDHA_ECOLI hmoment swissprot:XDHA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:XDHA_ECOLI iep swissprot:XDHA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:XDHA_ECOLI inforesidue swissprot:XDHA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:XDHA_ECOLI octanol swissprot:XDHA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:XDHA_ECOLI pepcoil swissprot:XDHA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:XDHA_ECOLI pepdigest swissprot:XDHA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:XDHA_ECOLI pepinfo swissprot:XDHA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:XDHA_ECOLI pepnet swissprot:XDHA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:XDHA_ECOLI pepstats swissprot:XDHA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:XDHA_ECOLI pepwheel swissprot:XDHA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:XDHA_ECOLI pepwindow swissprot:XDHA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:XDHA_ECOLI sigcleave swissprot:XDHA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:XDHA_ECOLI ## Database ID URL or Descriptions # AltName Isochorismate hydroxymutase {ECO:0000303|PubMed 8549818} # AltName Isochorismate mutase {ECO:0000255|HAMAP-Rule MF_01935} # BIOPHYSICOCHEMICAL PROPERTIES MENF_ECOLI Kinetic parameters KM=119 uM for isochorismate (at pH 7.5 and 37 degrees Celsius) {ECO 0000269|PubMed 9795253}; KM=166.9 uM for chorismate (at pH 7.5 and 37 degrees Celsius) {ECO 0000269|PubMed 9795253}; KM=192 uM for chorismate {ECO 0000269|PubMed 17240978}; KM=195 uM for chorismate {ECO 0000269|PubMed 9150206}; KM=770 uM for magnesium {ECO 0000269|PubMed 17240978}; Vmax=91.7 pmol/sec/mg enzyme with chorismate as substrate (at pH 7.5 and 37 degrees Celsius) {ECO 0000269|PubMed 9795253}; Vmax=2.4 pmol/sec/mg enzyme with isochorismate as substrate (at pH 7.5 and 37 degrees Celsius) {ECO 0000269|PubMed 9795253}; Note=kcat is 213 min(-1) for mutase activity with chorismate. kcat is 176 min(-1) for mutase activity with chorismate in the presence of 30 mM of beta-mercaptoethanol (BME). kcat is 144.9 min(-1) for mutase activity with chorismate (at pH 7.5 and 37 degrees Celsius). kcat is 80 min(-1) for mutase activity with chorismate in the absence of 30 mM of beta-mercaptoethanol (BME). kcat is 3.8 min(-1) for mutase activity with isochorismate (at pH 7.5 and 37 degrees Celsius. {ECO 0000269|PubMed 17240978, ECO 0000269|PubMed 9150206, ECO 0000269|PubMed 9795253}; pH dependence Optimum pH is between 7.5 and 8. The mutase activity decreases sharply at pH 6.5 and 9 to about 20% of that observed at the optimum pH. {ECO 0000269|PubMed 9150206, ECO 0000269|PubMed 9795253}; Temperature dependence Optimum temperature is 37 degrees Celsius. At 60 degrees Celsius the mutase activity is completely lost. {ECO 0000269|PubMed 9150206, ECO 0000269|PubMed 9795253}; # BRENDA 5.4.4 2026 # BioGrid 4262080 6 # CATALYTIC ACTIVITY MENF_ECOLI Chorismate = isochorismate. {ECO 0000255|HAMAP-Rule MF_01935, ECO 0000269|PubMed 17240978, ECO 0000269|PubMed 8764478, ECO 0000269|PubMed 9150206, ECO 0000269|PubMed 9795253}. # COFACTOR MENF_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_01935, ECO 0000269|PubMed 17240978, ECO 0000269|PubMed 18453696, ECO 0000269|PubMed 9150206, ECO 0000269|PubMed 9795253}; Note=Binds more tightly in the presence of chorismate. {ECO 0000269|PubMed 17240978}; # DISRUPTION PHENOTYPE Mutant produces only a trace of menaquinone. {ECO:0000269|PubMed 9795253}. # EcoGene EG12362 menF # FUNCTION MENF_ECOLI Catalyzes the conversion of chorismate to isochorismate. Can also catalyze the reverse reaction, but with a lower efficiency. {ECO 0000269|PubMed 17240978, ECO 0000269|PubMed 8764478, ECO 0000269|PubMed 9150206, ECO 0000269|PubMed 9795253}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0008909 isochorismate synthase activity; IDA:EcoCyc. # GO_process GO:0009234 menaquinone biosynthetic process; IMP:EcoCyc. # GO_process GO:0009697 salicylic acid biosynthetic process; IBA:GO_Central. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.60.120.10 -; 1. # HAMAP MF_01935 MenF # IntAct P38051 7 # InterPro IPR004561 IsoChor_synthase # InterPro IPR005801 ADC_synthase # InterPro IPR015890 Chorismate_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00130 Ubiquinone and other terpenoid-quinone biosynthesis # KEGG_Pathway ko01053 Biosynthesis of siderophore group nonribosomal peptides # Organism MENF_ECOLI Escherichia coli (strain K12) # PATHWAY MENF_ECOLI Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate step 1/7. {ECO 0000255|HAMAP-Rule MF_01935, ECO 0000269|PubMed 8549818, ECO 0000269|PubMed 9795253}. # PATHWAY MENF_ECOLI Quinol/quinone metabolism; menaquinone biosynthesis. {ECO 0000255|HAMAP-Rule MF_01935, ECO 0000269|PubMed 9795253}. # PATRIC 32119897 VBIEscCol129921_2358 # PDB 2EUA X-ray; 2.50 A; A/B=1-431 # PDB 3BZM X-ray; 1.95 A; A=1-431 # PDB 3BZN X-ray; 2.00 A; A=1-431 # PIR G64997 G64997 # Pfam PF00425 Chorismate_bind # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MENF_ECOLI Isochorismate synthase MenF {ECO 0000255|HAMAP-Rule MF_01935, ECO 0000303|PubMed 8764478} # RefSeq NP_416768 NC_000913.3 # RefSeq WP_001191419 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=M21787; Type=Frameshift; Positions=270, 310, 341; Evidence={ECO 0000305}; # SIMILARITY Belongs to the isochorismate synthase family. {ECO:0000255|HAMAP-Rule MF_01935, ECO:0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 9150206}. # SUPFAM SSF56322 SSF56322 # TIGRFAMs TIGR00543 isochor_syn # UniPathway UPA01057 UER00163 # eggNOG COG1169 LUCA # eggNOG ENOG4105E4F Bacteria BLAST swissprot:MENF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MENF_ECOLI BioCyc ECOL316407:JW2260-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2260-MONOMER BioCyc EcoCyc:MENF-MONOMER http://biocyc.org/getid?id=EcoCyc:MENF-MONOMER BioCyc MetaCyc:MENF-MONOMER http://biocyc.org/getid?id=MetaCyc:MENF-MONOMER COG COG1169 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1169 DIP DIP-10187N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10187N DOI 10.1016/0014-5793(95)01436-5 http://dx.doi.org/10.1016/0014-5793(95)01436-5 DOI 10.1016/0378-1097(96)00173-5 http://dx.doi.org/10.1016/0378-1097(96)00173-5 DOI 10.1016/S0304-4165(98)00089-0 http://dx.doi.org/10.1016/S0304-4165(98)00089-0 DOI 10.1021/bi0608515 http://dx.doi.org/10.1021/bi0608515 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1107/S0907444908005477 http://dx.doi.org/10.1107/S0907444908005477 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.4.4.2 {ECO:0000255|HAMAP-Rule:MF_01935, ECO:0000269|PubMed:17240978, ECO:0000269|PubMed:8764478, ECO:0000269|PubMed:9150206, ECO:0000269|PubMed:9795253} http://www.genome.jp/dbget-bin/www_bget?EC:5.4.4.2 {ECO:0000255|HAMAP-Rule:MF_01935, ECO:0000269|PubMed:17240978, ECO:0000269|PubMed:8764478, ECO:0000269|PubMed:9150206, ECO:0000269|PubMed:9795253} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M21787 http://www.ebi.ac.uk/ena/data/view/M21787 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U54790 http://www.ebi.ac.uk/ena/data/view/U54790 EMBL U58768 http://www.ebi.ac.uk/ena/data/view/U58768 EMBL Z50849 http://www.ebi.ac.uk/ena/data/view/Z50849 ENZYME 5.4.4.2 {ECO:0000255|HAMAP-Rule:MF_01935, ECO:0000269|PubMed:17240978, ECO:0000269|PubMed:8764478, ECO:0000269|PubMed:9150206, ECO:0000269|PubMed:9795253} http://enzyme.expasy.org/EC/5.4.4.2 {ECO:0000255|HAMAP-Rule:MF_01935, ECO:0000269|PubMed:17240978, ECO:0000269|PubMed:8764478, ECO:0000269|PubMed:9150206, ECO:0000269|PubMed:9795253} EchoBASE EB2265 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2265 EcoGene EG12362 http://www.ecogene.org/geneInfo.php?eg_id=EG12362 EnsemblBacteria AAC75325 http://www.ensemblgenomes.org/id/AAC75325 EnsemblBacteria AAC75325 http://www.ensemblgenomes.org/id/AAC75325 EnsemblBacteria BAA16092 http://www.ensemblgenomes.org/id/BAA16092 EnsemblBacteria BAA16092 http://www.ensemblgenomes.org/id/BAA16092 EnsemblBacteria BAA16092 http://www.ensemblgenomes.org/id/BAA16092 EnsemblBacteria b2265 http://www.ensemblgenomes.org/id/b2265 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0008909 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008909 GO_process GO:0009234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009234 GO_process GO:0009697 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009697 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.60.120.10 http://www.cathdb.info/version/latest/superfamily/3.60.120.10 GeneID 946712 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946712 HAMAP MF_01935 http://hamap.expasy.org/unirule/MF_01935 HOGENOM HOG000028186 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000028186&db=HOGENOM6 InParanoid P38051 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P38051 IntAct P38051 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P38051* IntEnz 5.4.4.2 {ECO:0000255|HAMAP-Rule:MF_01935, ECO:0000269|PubMed:17240978, ECO:0000269|PubMed:8764478, ECO:0000269|PubMed:9150206, ECO:0000269|PubMed:9795253} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.4.4.2 {ECO:0000255|HAMAP-Rule:MF_01935, ECO:0000269|PubMed:17240978, ECO:0000269|PubMed:8764478, ECO:0000269|PubMed:9150206, ECO:0000269|PubMed:9795253} InterPro IPR004561 http://www.ebi.ac.uk/interpro/entry/IPR004561 InterPro IPR005801 http://www.ebi.ac.uk/interpro/entry/IPR005801 InterPro IPR015890 http://www.ebi.ac.uk/interpro/entry/IPR015890 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2260 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2260 KEGG_Gene eco:b2265 http://www.genome.jp/dbget-bin/www_bget?eco:b2265 KEGG_Orthology KO:K02552 http://www.genome.jp/dbget-bin/www_bget?KO:K02552 KEGG_Pathway ko00130 http://www.genome.jp/kegg-bin/show_pathway?ko00130 KEGG_Pathway ko01053 http://www.genome.jp/kegg-bin/show_pathway?ko01053 KEGG_Reaction rn:R01717 http://www.genome.jp/dbget-bin/www_bget?rn:R01717 MINT MINT-1275996 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1275996 OMA RCIWTEL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RCIWTEL PDB 2EUA http://www.ebi.ac.uk/pdbe-srv/view/entry/2EUA PDB 3BZM http://www.ebi.ac.uk/pdbe-srv/view/entry/3BZM PDB 3BZN http://www.ebi.ac.uk/pdbe-srv/view/entry/3BZN PDBsum 2EUA http://www.ebi.ac.uk/pdbsum/2EUA PDBsum 3BZM http://www.ebi.ac.uk/pdbsum/3BZM PDBsum 3BZN http://www.ebi.ac.uk/pdbsum/3BZN PSORT swissprot:MENF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MENF_ECOLI PSORT-B swissprot:MENF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MENF_ECOLI PSORT2 swissprot:MENF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MENF_ECOLI Pfam PF00425 http://pfam.xfam.org/family/PF00425 Phobius swissprot:MENF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MENF_ECOLI PhylomeDB P38051 http://phylomedb.org/?seqid=P38051 ProteinModelPortal P38051 http://www.proteinmodelportal.org/query/uniprot/P38051 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17240978 http://www.ncbi.nlm.nih.gov/pubmed/17240978 PubMed 18453696 http://www.ncbi.nlm.nih.gov/pubmed/18453696 PubMed 2666397 http://www.ncbi.nlm.nih.gov/pubmed/2666397 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 8549818 http://www.ncbi.nlm.nih.gov/pubmed/8549818 PubMed 8764478 http://www.ncbi.nlm.nih.gov/pubmed/8764478 PubMed 9150206 http://www.ncbi.nlm.nih.gov/pubmed/9150206 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9795253 http://www.ncbi.nlm.nih.gov/pubmed/9795253 RefSeq NP_416768 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416768 RefSeq WP_001191419 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001191419 SMR P38051 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P38051 STRING 511145.b2265 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2265&targetmode=cogs STRING COG1169 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1169&targetmode=cogs SUPFAM SSF56322 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56322 TIGRFAMs TIGR00543 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00543 UniProtKB MENF_ECOLI http://www.uniprot.org/uniprot/MENF_ECOLI UniProtKB-AC P38051 http://www.uniprot.org/uniprot/P38051 charge swissprot:MENF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MENF_ECOLI eggNOG COG1169 http://eggnogapi.embl.de/nog_data/html/tree/COG1169 eggNOG ENOG4105E4F http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E4F epestfind swissprot:MENF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MENF_ECOLI garnier swissprot:MENF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MENF_ECOLI helixturnhelix swissprot:MENF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MENF_ECOLI hmoment swissprot:MENF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MENF_ECOLI iep swissprot:MENF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MENF_ECOLI inforesidue swissprot:MENF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MENF_ECOLI octanol swissprot:MENF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MENF_ECOLI pepcoil swissprot:MENF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MENF_ECOLI pepdigest swissprot:MENF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MENF_ECOLI pepinfo swissprot:MENF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MENF_ECOLI pepnet swissprot:MENF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MENF_ECOLI pepstats swissprot:MENF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MENF_ECOLI pepwheel swissprot:MENF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MENF_ECOLI pepwindow swissprot:MENF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MENF_ECOLI sigcleave swissprot:MENF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MENF_ECOLI ## Database ID URL or Descriptions # AltName RIR2_ECOLI Protein B2 # AltName RIR2_ECOLI Protein R2 # AltName RIR2_ECOLI Ribonucleotide reductase 1 # BRENDA 1.17.4 2026 # BioGrid 4260492 50 # CATALYTIC ACTIVITY 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H(2)O = ribonucleoside diphosphate + thioredoxin. {ECO:0000255|PROSITE-ProRule PRU10014}. # CDD cd01049 RNRR2 # COFACTOR Name=Fe cation; Xref=ChEBI:CHEBI 24875; Note=Binds 2 iron ions per subunit.; # ENZYME REGULATION Inhibited by hydroxyurea, leads to dNTP depletion, replication fork arrest and genomic instability. {ECO:0000305|PubMed 20005847}. # EcoGene EG10661 nrdB # FUNCTION RIR2_ECOLI Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R2 contains the tyrosyl radical required for catalysis. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0005971 ribonucleoside-diphosphate reductase complex; IDA:EcoliWiki. # GO_function GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IEA:UniProtKB-EC. # GO_function GO:0005506 iron ion binding; IDA:EcoCyc. # GO_process GO:0006260 DNA replication; IEA:UniProtKB-UniPathway. # GO_process GO:0009263 deoxyribonucleotide biosynthetic process; IDA:EcoliWiki. # GO_process GO:0015949 nucleobase-containing small molecule interconversion; IDA:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.620.20 -; 1. # INDUCTION Induced 4.2-fold by hydroxyurea (at protein level). {ECO:0000269|PubMed 20005847}. # INTERACTION RIR2_ECOLI Self; NbExp=2; IntAct=EBI-555196, EBI-555196; # IntAct P69924 12 # InterPro IPR000358 RNR_small_fam # InterPro IPR009078 Ferritin-like_SF # InterPro IPR012348 RNR-rel # InterPro IPR030475 RNR_small_AS # InterPro IPR033909 RNR_small # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00240 Pyrimidine metabolism # MISCELLANEOUS RIR2_ECOLI A substrate-binding catalytic site, located on R1, is formed only in the presence of the second subunit R2. # MISCELLANEOUS RIR2_ECOLI E.coli produces two separate class I enzymes. This one is the functional enzyme during growth. # Organism RIR2_ECOLI Escherichia coli (strain K12) # PANTHER PTHR23409 PTHR23409; 2 # PATHWAY RIR2_ECOLI Genetic information processing; DNA replication. # PATRIC 32119829 VBIEscCol129921_2324 # PDB 1AV8 X-ray; 2.80 A; A/B=2-341 # PDB 1BIQ X-ray; 2.05 A; A/B=2-376 # PDB 1JPR X-ray; 1.88 A; A/B=2-376 # PDB 1JQC X-ray; 1.61 A; A/B=2-376 # PDB 1MRR X-ray; 2.50 A; A/B=2-376 # PDB 1MXR X-ray; 1.42 A; A/B=2-376 # PDB 1PFR X-ray; 2.20 A; A/B=2-341 # PDB 1PIM X-ray; 2.00 A; A/B=2-376 # PDB 1PIU X-ray; 2.20 A; A/B=2-376 # PDB 1PIY X-ray; 1.68 A; A/B=2-376 # PDB 1PIZ X-ray; 1.90 A; A/B=2-376 # PDB 1PJ0 X-ray; 1.90 A; A/B=2-376 # PDB 1PJ1 X-ray; 1.95 A; A/B=2-376 # PDB 1PM2 X-ray; 1.80 A; A/B=2-340 # PDB 1R1R X-ray; 2.90 A; D/E/F/P=357-376 # PDB 1R65 X-ray; 1.95 A; A/B=2-376 # PDB 1RIB X-ray; 2.20 A; A/B=2-376 # PDB 1RNR X-ray; 2.50 A; A/B=2-376 # PDB 1RSR X-ray; 2.00 A; A/B=2-376 # PDB 1RSV X-ray; 2.20 A; A/B=2-376 # PDB 1XIK X-ray; 1.70 A; A/B=2-376 # PDB 1YFD X-ray; 1.90 A; A/B=2-376 # PDB 2ALX X-ray; 2.60 A; A=1-340 # PDB 2AV8 X-ray; 2.46 A; A/B=2-341 # PDB 2R1R X-ray; 3.00 A; D/E/F/P=357-376 # PDB 2X0X X-ray; 2.30 A; D/E/F/P=357-376 # PDB 2XAK X-ray; 2.80 A; D/E/F/P=357-376 # PDB 2XAP X-ray; 2.10 A; D/E/F/P=357-376 # PDB 2XAV X-ray; 2.80 A; D/E/F/P=357-376 # PDB 2XAW X-ray; 3.10 A; D/E/F/P=357-376 # PDB 2XAX X-ray; 2.75 A; D/E/F/P=357-376 # PDB 2XAY X-ray; 2.65 A; D/E/F/P=357-376 # PDB 2XAZ X-ray; 2.60 A; D/E/F/P=357-376 # PDB 2XO4 X-ray; 2.50 A; D/E/F/P=357-376 # PDB 2XO5 X-ray; 2.70 A; D/E/F/P=357-376 # PDB 2XOF X-ray; 2.20 A; A/B=2-376 # PDB 3R1R X-ray; 3.00 A; D/E/F/P=357-376 # PDB 3UUS X-ray; 5.65 A; E/F/G/H=2-376 # PDB 4ERM X-ray; 3.95 A; E/F/G/H=2-376 # PDB 4ERP X-ray; 4.45 A; E/F/G/H=2-376 # PDB 4R1R X-ray; 3.20 A; D/E/F/P=357-376 # PDB 5CI2 X-ray; 2.25 A; A=2-376 # PDB 5CI3 X-ray; 2.40 A; A=2-376 # PDB 5CNS X-ray; 2.98 A; E/F/G/H=2-376 # PDB 5CNT X-ray; 3.25 A; E/F/G/H=2-376 # PDB 5CNU X-ray; 3.40 A; E/F/G/H=2-376 # PDB 5CNV X-ray; 3.20 A; E/F/G/H=2-376 # PDB 5R1R X-ray; 3.10 A; D/E/F/P=357-376 # PDB 6R1R X-ray; 3.10 A; D/E/F/P=357-376 # PDB 7R1R X-ray; 3.10 A; D/E/F/P=357-376 # PIR A00527 RDEC2R # PROSITE PS00368 RIBORED_SMALL # Pfam PF00268 Ribonuc_red_sm # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RIR2_ECOLI Ribonucleoside-diphosphate reductase 1 subunit beta # RefSeq NP_416738 NC_000913.3 # RefSeq WP_000332037 NZ_LN832404.1 # SIMILARITY Belongs to the ribonucleoside diphosphate reductase small chain family. {ECO 0000305}. # SUBUNIT RIR2_ECOLI Tetramer of two alpha (R1) and two beta (R2) subunits. The B1 protein is a dimer of alpha subunits. A radical transfer pathway occurs between Tyr-123 of R2 and R1. # SUPFAM SSF47240 SSF47240 # eggNOG COG0208 LUCA # eggNOG ENOG4105E05 Bacteria BLAST swissprot:RIR2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RIR2_ECOLI BioCyc ECOL316407:JW2229-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2229-MONOMER BioCyc EcoCyc:NRDB-MONOMER http://biocyc.org/getid?id=EcoCyc:NRDB-MONOMER BioCyc MetaCyc:NRDB-MONOMER http://biocyc.org/getid?id=MetaCyc:NRDB-MONOMER COG COG0208 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0208 DIP DIP-36213N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36213N DOI 10.1006/jmbi.1993.1374 http://dx.doi.org/10.1006/jmbi.1993.1374 DOI 10.1007/s007750000205 http://dx.doi.org/10.1007/s007750000205 DOI 10.1016/S0969-2126(96)00112-8 http://dx.doi.org/10.1016/S0969-2126(96)00112-8 DOI 10.1016/S0969-2126(97)00259-1 http://dx.doi.org/10.1016/S0969-2126(97)00259-1 DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1021/bi9728811 http://dx.doi.org/10.1021/bi9728811 DOI 10.1021/bi9806403 http://dx.doi.org/10.1021/bi9806403 DOI 10.1038/345593a0 http://dx.doi.org/10.1038/345593a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.81.14.4294 http://dx.doi.org/10.1073/pnas.81.14.4294 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DisProt DP00107 http://www.disprot.org/protein.php?id=DP00107 EC_number EC:1.17.4.1 http://www.genome.jp/dbget-bin/www_bget?EC:1.17.4.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K02672 http://www.ebi.ac.uk/ena/data/view/K02672 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.17.4.1 http://enzyme.expasy.org/EC/1.17.4.1 EchoBASE EB0655 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0655 EcoGene EG10661 http://www.ecogene.org/geneInfo.php?eg_id=EG10661 EnsemblBacteria AAC75295 http://www.ensemblgenomes.org/id/AAC75295 EnsemblBacteria AAC75295 http://www.ensemblgenomes.org/id/AAC75295 EnsemblBacteria BAA16054 http://www.ensemblgenomes.org/id/BAA16054 EnsemblBacteria BAA16054 http://www.ensemblgenomes.org/id/BAA16054 EnsemblBacteria BAA16054 http://www.ensemblgenomes.org/id/BAA16054 EnsemblBacteria b2235 http://www.ensemblgenomes.org/id/b2235 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005971 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005971 GO_function GO:0004748 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004748 GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_process GO:0006260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260 GO_process GO:0009263 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009263 GO_process GO:0015949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015949 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.620.20 http://www.cathdb.info/version/latest/superfamily/1.10.620.20 GeneID 946732 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946732 HOGENOM HOG000278087 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278087&db=HOGENOM6 InParanoid P69924 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P69924 IntAct P69924 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69924* IntEnz 1.17.4.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.17.4.1 InterPro IPR000358 http://www.ebi.ac.uk/interpro/entry/IPR000358 InterPro IPR009078 http://www.ebi.ac.uk/interpro/entry/IPR009078 InterPro IPR012348 http://www.ebi.ac.uk/interpro/entry/IPR012348 InterPro IPR030475 http://www.ebi.ac.uk/interpro/entry/IPR030475 InterPro IPR033909 http://www.ebi.ac.uk/interpro/entry/IPR033909 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW2229 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2229 KEGG_Gene eco:b2235 http://www.genome.jp/dbget-bin/www_bget?eco:b2235 KEGG_Orthology KO:K00526 http://www.genome.jp/dbget-bin/www_bget?KO:K00526 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Reaction rn:R02017 http://www.genome.jp/dbget-bin/www_bget?rn:R02017 KEGG_Reaction rn:R02018 http://www.genome.jp/dbget-bin/www_bget?rn:R02018 KEGG_Reaction rn:R02019 http://www.genome.jp/dbget-bin/www_bget?rn:R02019 KEGG_Reaction rn:R02024 http://www.genome.jp/dbget-bin/www_bget?rn:R02024 MINT MINT-1269534 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1269534 OMA LEPMFLG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LEPMFLG PANTHER PTHR23409 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23409 PDB 1AV8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1AV8 PDB 1BIQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1BIQ PDB 1JPR http://www.ebi.ac.uk/pdbe-srv/view/entry/1JPR PDB 1JQC http://www.ebi.ac.uk/pdbe-srv/view/entry/1JQC PDB 1MRR http://www.ebi.ac.uk/pdbe-srv/view/entry/1MRR PDB 1MXR http://www.ebi.ac.uk/pdbe-srv/view/entry/1MXR PDB 1PFR http://www.ebi.ac.uk/pdbe-srv/view/entry/1PFR PDB 1PIM http://www.ebi.ac.uk/pdbe-srv/view/entry/1PIM PDB 1PIU http://www.ebi.ac.uk/pdbe-srv/view/entry/1PIU PDB 1PIY http://www.ebi.ac.uk/pdbe-srv/view/entry/1PIY PDB 1PIZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1PIZ PDB 1PJ0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1PJ0 PDB 1PJ1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1PJ1 PDB 1PM2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1PM2 PDB 1R1R http://www.ebi.ac.uk/pdbe-srv/view/entry/1R1R PDB 1R65 http://www.ebi.ac.uk/pdbe-srv/view/entry/1R65 PDB 1RIB http://www.ebi.ac.uk/pdbe-srv/view/entry/1RIB PDB 1RNR http://www.ebi.ac.uk/pdbe-srv/view/entry/1RNR PDB 1RSR http://www.ebi.ac.uk/pdbe-srv/view/entry/1RSR PDB 1RSV http://www.ebi.ac.uk/pdbe-srv/view/entry/1RSV PDB 1XIK http://www.ebi.ac.uk/pdbe-srv/view/entry/1XIK PDB 1YFD http://www.ebi.ac.uk/pdbe-srv/view/entry/1YFD PDB 2ALX http://www.ebi.ac.uk/pdbe-srv/view/entry/2ALX PDB 2AV8 http://www.ebi.ac.uk/pdbe-srv/view/entry/2AV8 PDB 2R1R http://www.ebi.ac.uk/pdbe-srv/view/entry/2R1R PDB 2X0X http://www.ebi.ac.uk/pdbe-srv/view/entry/2X0X PDB 2XAK http://www.ebi.ac.uk/pdbe-srv/view/entry/2XAK PDB 2XAP http://www.ebi.ac.uk/pdbe-srv/view/entry/2XAP PDB 2XAV http://www.ebi.ac.uk/pdbe-srv/view/entry/2XAV PDB 2XAW http://www.ebi.ac.uk/pdbe-srv/view/entry/2XAW PDB 2XAX http://www.ebi.ac.uk/pdbe-srv/view/entry/2XAX PDB 2XAY http://www.ebi.ac.uk/pdbe-srv/view/entry/2XAY PDB 2XAZ http://www.ebi.ac.uk/pdbe-srv/view/entry/2XAZ PDB 2XO4 http://www.ebi.ac.uk/pdbe-srv/view/entry/2XO4 PDB 2XO5 http://www.ebi.ac.uk/pdbe-srv/view/entry/2XO5 PDB 2XOF http://www.ebi.ac.uk/pdbe-srv/view/entry/2XOF PDB 3R1R http://www.ebi.ac.uk/pdbe-srv/view/entry/3R1R PDB 3UUS http://www.ebi.ac.uk/pdbe-srv/view/entry/3UUS PDB 4ERM http://www.ebi.ac.uk/pdbe-srv/view/entry/4ERM PDB 4ERP http://www.ebi.ac.uk/pdbe-srv/view/entry/4ERP PDB 4R1R http://www.ebi.ac.uk/pdbe-srv/view/entry/4R1R PDB 5CI2 http://www.ebi.ac.uk/pdbe-srv/view/entry/5CI2 PDB 5CI3 http://www.ebi.ac.uk/pdbe-srv/view/entry/5CI3 PDB 5CNS http://www.ebi.ac.uk/pdbe-srv/view/entry/5CNS PDB 5CNT http://www.ebi.ac.uk/pdbe-srv/view/entry/5CNT PDB 5CNU http://www.ebi.ac.uk/pdbe-srv/view/entry/5CNU PDB 5CNV http://www.ebi.ac.uk/pdbe-srv/view/entry/5CNV PDB 5R1R http://www.ebi.ac.uk/pdbe-srv/view/entry/5R1R PDB 6R1R http://www.ebi.ac.uk/pdbe-srv/view/entry/6R1R PDB 7R1R http://www.ebi.ac.uk/pdbe-srv/view/entry/7R1R PDBsum 1AV8 http://www.ebi.ac.uk/pdbsum/1AV8 PDBsum 1BIQ http://www.ebi.ac.uk/pdbsum/1BIQ PDBsum 1JPR http://www.ebi.ac.uk/pdbsum/1JPR PDBsum 1JQC http://www.ebi.ac.uk/pdbsum/1JQC PDBsum 1MRR http://www.ebi.ac.uk/pdbsum/1MRR PDBsum 1MXR http://www.ebi.ac.uk/pdbsum/1MXR PDBsum 1PFR http://www.ebi.ac.uk/pdbsum/1PFR PDBsum 1PIM http://www.ebi.ac.uk/pdbsum/1PIM PDBsum 1PIU http://www.ebi.ac.uk/pdbsum/1PIU PDBsum 1PIY http://www.ebi.ac.uk/pdbsum/1PIY PDBsum 1PIZ http://www.ebi.ac.uk/pdbsum/1PIZ PDBsum 1PJ0 http://www.ebi.ac.uk/pdbsum/1PJ0 PDBsum 1PJ1 http://www.ebi.ac.uk/pdbsum/1PJ1 PDBsum 1PM2 http://www.ebi.ac.uk/pdbsum/1PM2 PDBsum 1R1R http://www.ebi.ac.uk/pdbsum/1R1R PDBsum 1R65 http://www.ebi.ac.uk/pdbsum/1R65 PDBsum 1RIB http://www.ebi.ac.uk/pdbsum/1RIB PDBsum 1RNR http://www.ebi.ac.uk/pdbsum/1RNR PDBsum 1RSR http://www.ebi.ac.uk/pdbsum/1RSR PDBsum 1RSV http://www.ebi.ac.uk/pdbsum/1RSV PDBsum 1XIK http://www.ebi.ac.uk/pdbsum/1XIK PDBsum 1YFD http://www.ebi.ac.uk/pdbsum/1YFD PDBsum 2ALX http://www.ebi.ac.uk/pdbsum/2ALX PDBsum 2AV8 http://www.ebi.ac.uk/pdbsum/2AV8 PDBsum 2R1R http://www.ebi.ac.uk/pdbsum/2R1R PDBsum 2X0X http://www.ebi.ac.uk/pdbsum/2X0X PDBsum 2XAK http://www.ebi.ac.uk/pdbsum/2XAK PDBsum 2XAP http://www.ebi.ac.uk/pdbsum/2XAP PDBsum 2XAV http://www.ebi.ac.uk/pdbsum/2XAV PDBsum 2XAW http://www.ebi.ac.uk/pdbsum/2XAW PDBsum 2XAX http://www.ebi.ac.uk/pdbsum/2XAX PDBsum 2XAY http://www.ebi.ac.uk/pdbsum/2XAY PDBsum 2XAZ http://www.ebi.ac.uk/pdbsum/2XAZ PDBsum 2XO4 http://www.ebi.ac.uk/pdbsum/2XO4 PDBsum 2XO5 http://www.ebi.ac.uk/pdbsum/2XO5 PDBsum 2XOF http://www.ebi.ac.uk/pdbsum/2XOF PDBsum 3R1R http://www.ebi.ac.uk/pdbsum/3R1R PDBsum 3UUS http://www.ebi.ac.uk/pdbsum/3UUS PDBsum 4ERM http://www.ebi.ac.uk/pdbsum/4ERM PDBsum 4ERP http://www.ebi.ac.uk/pdbsum/4ERP PDBsum 4R1R http://www.ebi.ac.uk/pdbsum/4R1R PDBsum 5CI2 http://www.ebi.ac.uk/pdbsum/5CI2 PDBsum 5CI3 http://www.ebi.ac.uk/pdbsum/5CI3 PDBsum 5CNS http://www.ebi.ac.uk/pdbsum/5CNS PDBsum 5CNT http://www.ebi.ac.uk/pdbsum/5CNT PDBsum 5CNU http://www.ebi.ac.uk/pdbsum/5CNU PDBsum 5CNV http://www.ebi.ac.uk/pdbsum/5CNV PDBsum 5R1R http://www.ebi.ac.uk/pdbsum/5R1R PDBsum 6R1R http://www.ebi.ac.uk/pdbsum/6R1R PDBsum 7R1R http://www.ebi.ac.uk/pdbsum/7R1R PROSITE PS00368 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00368 PSORT swissprot:RIR2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RIR2_ECOLI PSORT-B swissprot:RIR2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RIR2_ECOLI PSORT2 swissprot:RIR2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RIR2_ECOLI Pfam PF00268 http://pfam.xfam.org/family/PF00268 Phobius swissprot:RIR2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RIR2_ECOLI PhylomeDB P69924 http://phylomedb.org/?seqid=P69924 ProteinModelPortal P69924 http://www.proteinmodelportal.org/query/uniprot/P69924 PubMed 11315567 http://www.ncbi.nlm.nih.gov/pubmed/11315567 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 2190093 http://www.ncbi.nlm.nih.gov/pubmed/2190093 PubMed 3511029 http://www.ncbi.nlm.nih.gov/pubmed/3511029 PubMed 6087316 http://www.ncbi.nlm.nih.gov/pubmed/6087316 PubMed 8331655 http://www.ncbi.nlm.nih.gov/pubmed/8331655 PubMed 8805591 http://www.ncbi.nlm.nih.gov/pubmed/8805591 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9309223 http://www.ncbi.nlm.nih.gov/pubmed/9309223 PubMed 9558317 http://www.ncbi.nlm.nih.gov/pubmed/9558317 PubMed 9692970 http://www.ncbi.nlm.nih.gov/pubmed/9692970 RefSeq NP_416738 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416738 RefSeq WP_000332037 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000332037 SMR P69924 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69924 STRING 511145.b2235 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2235&targetmode=cogs STRING COG0208 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0208&targetmode=cogs SUPFAM SSF47240 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47240 UniProtKB RIR2_ECOLI http://www.uniprot.org/uniprot/RIR2_ECOLI UniProtKB-AC P69924 http://www.uniprot.org/uniprot/P69924 charge swissprot:RIR2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RIR2_ECOLI eggNOG COG0208 http://eggnogapi.embl.de/nog_data/html/tree/COG0208 eggNOG ENOG4105E05 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E05 epestfind swissprot:RIR2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RIR2_ECOLI garnier swissprot:RIR2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RIR2_ECOLI helixturnhelix swissprot:RIR2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RIR2_ECOLI hmoment swissprot:RIR2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RIR2_ECOLI iep swissprot:RIR2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RIR2_ECOLI inforesidue swissprot:RIR2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RIR2_ECOLI octanol swissprot:RIR2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RIR2_ECOLI pepcoil swissprot:RIR2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RIR2_ECOLI pepdigest swissprot:RIR2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RIR2_ECOLI pepinfo swissprot:RIR2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RIR2_ECOLI pepnet swissprot:RIR2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RIR2_ECOLI pepstats swissprot:RIR2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RIR2_ECOLI pepwheel swissprot:RIR2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RIR2_ECOLI pepwindow swissprot:RIR2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RIR2_ECOLI sigcleave swissprot:RIR2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RIR2_ECOLI ## Database ID URL or Descriptions # BRENDA 2.7.10 2026 # BioGrid 4262960 334 # CATALYTIC ACTIVITY WZC_ECOLI ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. # ENZYME REGULATION WZC_ECOLI Dephosphorylated and activated by wzb. # EcoGene EG13568 wzc # FUNCTION WZC_ECOLI Required for the extracellular polysaccharide colanic acid synthesis. The autophosphorylated form is inactive. Probably involved in the export of colanic acid from the cell to medium. Phosphorylates udg. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:EcoCyc. # GO_function GO:0004713 protein tyrosine kinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016887 ATPase activity; IDA:EcoCyc. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IEA:InterPro. # GO_process GO:0009242 colanic acid biosynthetic process; IMP:EcoCyc. # GO_process GO:0018108 peptidyl-tyrosine phosphorylation; IDA:EcoCyc. # GO_process GO:0038083 peptidyl-tyrosine autophosphorylation; IDA:EcoCyc. # GO_process GO:0045226 extracellular polysaccharide biosynthetic process; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.300 -; 1. # IntAct P76387 4 # InterPro IPR003856 LipoPS_biosynth # InterPro IPR005702 EPS_synthesis # InterPro IPR025669 AAA_dom # InterPro IPR027417 P-loop_NTPase # InterPro IPR032807 GNVR # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01001 Protein kinases # MISCELLANEOUS WZC_ECOLI Additional site-directed mutagenesis experiments indicated that the tyrosine residues at positions 708, 710, 711, 713 and 715 are phosphorylation sites, whereas tyrosine at position 705 is not. # Organism WZC_ECOLI Escherichia coli (strain K12) # PATHWAY WZC_ECOLI Glycan metabolism; exopolysaccharide biosynthesis. # PATRIC 32119453 VBIEscCol129921_2137 # PDB 3LA6 X-ray; 3.20 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P=447-720 # PIR C64972 C64972 # PTM WZC_ECOLI Autophosphorylated. Seems to be phosphorylated through a cooperative two-step mechanism. First, Tyr-569 is phosphorylated in an intramolecular reaction that generates a significant increase of protein kinase activity. Then Tyr-708, Tyr-710, Tyr- 711, Tyr-713 and Tyr-715 are phosphorylated in an intermolecular Tyr-569-dependent reaction. {ECO 0000269|PubMed 12851388}. # Pfam PF02706 Wzz # Pfam PF13614 AAA_31 # Pfam PF13807 GNVR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName WZC_ECOLI Tyrosine-protein kinase wzc # RefSeq NP_416564 NC_000913.3 # RefSeq WP_000137196 NZ_LN832404.1 # SIMILARITY Belongs to the etk/wzc family. {ECO 0000305}. # SUBCELLULAR LOCATION WZC_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF52540 SSF52540 # TCDB 8.A.3.3 the cytoplasmic membrane-periplasmic auxiliary-1 (mpa1) protein with cytoplasmic (c) domain (mpa1-c or mpa1+c) family # TIGRFAMs TIGR01007 eps_fam # eggNOG COG0489 LUCA # eggNOG COG3206 LUCA # eggNOG ENOG4105D75 Bacteria BLAST swissprot:WZC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:WZC_ECOLI BioCyc ECOL316407:JW2045-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2045-MONOMER BioCyc EcoCyc:G7105-MONOMER http://biocyc.org/getid?id=EcoCyc:G7105-MONOMER BioCyc MetaCyc:G7105-MONOMER http://biocyc.org/getid?id=MetaCyc:G7105-MONOMER COG COG0489 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0489 COG COG3206 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3206 DIP DIP-28075N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-28075N DOI 10.1006/jmbi.2000.4217 http://dx.doi.org/10.1006/jmbi.2000.4217 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M110880200 http://dx.doi.org/10.1074/jbc.M110880200 DOI 10.1074/jbc.M305134200 http://dx.doi.org/10.1074/jbc.M305134200 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.10.- http://www.genome.jp/dbget-bin/www_bget?EC:2.7.10.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U38473 http://www.ebi.ac.uk/ena/data/view/U38473 ENZYME 2.7.10.- http://enzyme.expasy.org/EC/2.7.10.- EchoBASE EB3338 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3338 EcoGene EG13568 http://www.ecogene.org/geneInfo.php?eg_id=EG13568 EnsemblBacteria AAC75121 http://www.ensemblgenomes.org/id/AAC75121 EnsemblBacteria AAC75121 http://www.ensemblgenomes.org/id/AAC75121 EnsemblBacteria BAA15913 http://www.ensemblgenomes.org/id/BAA15913 EnsemblBacteria BAA15913 http://www.ensemblgenomes.org/id/BAA15913 EnsemblBacteria BAA15913 http://www.ensemblgenomes.org/id/BAA15913 EnsemblBacteria b2060 http://www.ensemblgenomes.org/id/b2060 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0004713 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004713 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GO_process GO:0009242 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009242 GO_process GO:0018108 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018108 GO_process GO:0038083 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0038083 GO_process GO:0045226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045226 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 946567 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946567 HOGENOM HOG000153997 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000153997&db=HOGENOM6 InParanoid P76387 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76387 IntAct P76387 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76387* IntEnz 2.7.10 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.10 InterPro IPR003856 http://www.ebi.ac.uk/interpro/entry/IPR003856 InterPro IPR005702 http://www.ebi.ac.uk/interpro/entry/IPR005702 InterPro IPR025669 http://www.ebi.ac.uk/interpro/entry/IPR025669 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR032807 http://www.ebi.ac.uk/interpro/entry/IPR032807 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01001 http://www.genome.jp/dbget-bin/www_bget?ko01001 KEGG_Gene ecj:JW2045 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2045 KEGG_Gene eco:b2060 http://www.genome.jp/dbget-bin/www_bget?eco:b2060 KEGG_Orthology KO:K16692 http://www.genome.jp/dbget-bin/www_bget?KO:K16692 MINT MINT-8293229 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8293229 OMA TKDHPAY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TKDHPAY PDB 3LA6 http://www.ebi.ac.uk/pdbe-srv/view/entry/3LA6 PDBsum 3LA6 http://www.ebi.ac.uk/pdbsum/3LA6 PSORT swissprot:WZC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:WZC_ECOLI PSORT-B swissprot:WZC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:WZC_ECOLI PSORT2 swissprot:WZC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:WZC_ECOLI Pfam PF02706 http://pfam.xfam.org/family/PF02706 Pfam PF13614 http://pfam.xfam.org/family/PF13614 Pfam PF13807 http://pfam.xfam.org/family/PF13807 Phobius swissprot:WZC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:WZC_ECOLI PhylomeDB P76387 http://phylomedb.org/?seqid=P76387 ProteinModelPortal P76387 http://www.proteinmodelportal.org/query/uniprot/P76387 PubMed 10348860 http://www.ncbi.nlm.nih.gov/pubmed/10348860 PubMed 11090276 http://www.ncbi.nlm.nih.gov/pubmed/11090276 PubMed 11751920 http://www.ncbi.nlm.nih.gov/pubmed/11751920 PubMed 12851388 http://www.ncbi.nlm.nih.gov/pubmed/12851388 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8759852 http://www.ncbi.nlm.nih.gov/pubmed/8759852 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416564 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416564 RefSeq WP_000137196 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000137196 SMR P76387 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76387 STRING 511145.b2060 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2060&targetmode=cogs STRING COG0489 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0489&targetmode=cogs STRING COG3206 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3206&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 8.A.3.3 http://www.tcdb.org/search/result.php?tc=8.A.3.3 TIGRFAMs TIGR01007 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01007 UniProtKB WZC_ECOLI http://www.uniprot.org/uniprot/WZC_ECOLI UniProtKB-AC P76387 http://www.uniprot.org/uniprot/P76387 charge swissprot:WZC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:WZC_ECOLI eggNOG COG0489 http://eggnogapi.embl.de/nog_data/html/tree/COG0489 eggNOG COG3206 http://eggnogapi.embl.de/nog_data/html/tree/COG3206 eggNOG ENOG4105D75 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D75 epestfind swissprot:WZC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:WZC_ECOLI garnier swissprot:WZC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:WZC_ECOLI helixturnhelix swissprot:WZC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:WZC_ECOLI hmoment swissprot:WZC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:WZC_ECOLI iep swissprot:WZC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:WZC_ECOLI inforesidue swissprot:WZC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:WZC_ECOLI octanol swissprot:WZC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:WZC_ECOLI pepcoil swissprot:WZC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:WZC_ECOLI pepdigest swissprot:WZC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:WZC_ECOLI pepinfo swissprot:WZC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:WZC_ECOLI pepnet swissprot:WZC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:WZC_ECOLI pepstats swissprot:WZC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:WZC_ECOLI pepwheel swissprot:WZC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:WZC_ECOLI pepwindow swissprot:WZC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:WZC_ECOLI sigcleave swissprot:WZC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:WZC_ECOLI ## Database ID URL or Descriptions # AltName ISPD_ECOLI 4-diphosphocytidyl-2C-methyl-D-erythritol synthase # AltName ISPD_ECOLI CDP-ME synthase # AltName ISPD_ECOLI MEP cytidylyltransferase # BIOPHYSICOCHEMICAL PROPERTIES pH dependence Optimum pH is 8.3.; # BRENDA 2.7.7.60 2026 # BioGrid 4262280 173 # CATALYTIC ACTIVITY ISPD_ECOLI CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. # CDD cd02516 CDP-ME_synthetase # COFACTOR ISPD_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Name=Co(2+); Xref=ChEBI CHEBI 48828; # EcoGene EG13110 ispD # FUNCTION ISPD_ECOLI Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP). # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0050518 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity; IDA:EcoCyc. # GO_process GO:0016114 terpenoid biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0019288 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.90.550.10 -; 1. # HAMAP MF_00108 IspD # IntAct Q46893 2 # InterPro IPR001228 IspD # InterPro IPR018294 ISPD_synthase_CS # InterPro IPR029044 Nucleotide-diphossugar_trans # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00900 Terpenoid backbone biosynthesis # MISCELLANEOUS ISPD_ECOLI There are no coordination bonds that occur between IspD and magnesium in any of the complexes examined to date. # Organism ISPD_ECOLI Escherichia coli (strain K12) # PATHWAY Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1- deoxy-D-xylulose 5-phosphate step 2/6. # PATRIC 32120900 VBIEscCol129921_2842 # PDB 1H3M X-ray; 2.40 A; A/B=2-236 # PDB 1I52 X-ray; 1.50 A; A=1-236 # PDB 1INI X-ray; 1.82 A; A=1-236 # PDB 1INJ X-ray; 1.55 A; A=1-236 # PDB 1VGT X-ray; 1.80 A; A/B=2-236 # PDB 1VGU X-ray; 2.80 A; A/B=2-236 # PDB 3N9W X-ray; 1.90 A; A/B=2-236 # PIR G65055 G65055 # PROSITE PS01295 ISPD # Pfam PF01128 IspD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ISPD_ECOLI 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase # RefSeq NP_417227 NC_000913.3 # RefSeq WP_000246138 NZ_LN832404.1 # SIMILARITY Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 11427897}. # SUPFAM SSF53448 SSF53448 # TIGRFAMs TIGR00453 ispD # UniPathway UPA00056 UER00093 # eggNOG COG1211 LUCA # eggNOG ENOG4105CE5 Bacteria BLAST swissprot:ISPD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ISPD_ECOLI BioCyc ECOL316407:JW2717-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2717-MONOMER BioCyc EcoCyc:G7423-MONOMER http://biocyc.org/getid?id=EcoCyc:G7423-MONOMER BioCyc MetaCyc:G7423-MONOMER http://biocyc.org/getid?id=MetaCyc:G7423-MONOMER COG COG1211 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1211 DOI 10.1016/S0006-291X(03)01211-7 http://dx.doi.org/10.1016/S0006-291X(03)01211-7 DOI 10.1038/89691 http://dx.doi.org/10.1038/89691 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.96.21.11758 http://dx.doi.org/10.1073/pnas.96.21.11758 DOI 10.1107/S0907444901010137 http://dx.doi.org/10.1107/S0907444901010137 DOI 10.1107/S090744490202365X http://dx.doi.org/10.1107/S090744490202365X DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.7.60 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.60 EMBL AB037143 http://www.ebi.ac.uk/ena/data/view/AB037143 EMBL AF230736 http://www.ebi.ac.uk/ena/data/view/AF230736 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 ENZYME 2.7.7.60 http://enzyme.expasy.org/EC/2.7.7.60 EchoBASE EB2913 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2913 EcoGene EG13110 http://www.ecogene.org/geneInfo.php?eg_id=EG13110 EnsemblBacteria AAC75789 http://www.ensemblgenomes.org/id/AAC75789 EnsemblBacteria AAC75789 http://www.ensemblgenomes.org/id/AAC75789 EnsemblBacteria BAE76824 http://www.ensemblgenomes.org/id/BAE76824 EnsemblBacteria BAE76824 http://www.ensemblgenomes.org/id/BAE76824 EnsemblBacteria BAE76824 http://www.ensemblgenomes.org/id/BAE76824 EnsemblBacteria b2747 http://www.ensemblgenomes.org/id/b2747 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0050518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050518 GO_process GO:0016114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016114 GO_process GO:0019288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019288 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.90.550.10 http://www.cathdb.info/version/latest/superfamily/3.90.550.10 GeneID 948269 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948269 HAMAP MF_00108 http://hamap.expasy.org/unirule/MF_00108 HOGENOM HOG000218564 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218564&db=HOGENOM6 InParanoid Q46893 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46893 IntAct Q46893 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46893* IntEnz 2.7.7.60 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.60 InterPro IPR001228 http://www.ebi.ac.uk/interpro/entry/IPR001228 InterPro IPR018294 http://www.ebi.ac.uk/interpro/entry/IPR018294 InterPro IPR029044 http://www.ebi.ac.uk/interpro/entry/IPR029044 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2717 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2717 KEGG_Gene eco:b2747 http://www.genome.jp/dbget-bin/www_bget?eco:b2747 KEGG_Orthology KO:K00991 http://www.genome.jp/dbget-bin/www_bget?KO:K00991 KEGG_Pathway ko00900 http://www.genome.jp/kegg-bin/show_pathway?ko00900 KEGG_Reaction rn:R05633 http://www.genome.jp/dbget-bin/www_bget?rn:R05633 OMA QAYTPQM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QAYTPQM PDB 1H3M http://www.ebi.ac.uk/pdbe-srv/view/entry/1H3M PDB 1I52 http://www.ebi.ac.uk/pdbe-srv/view/entry/1I52 PDB 1INI http://www.ebi.ac.uk/pdbe-srv/view/entry/1INI PDB 1INJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1INJ PDB 1VGT http://www.ebi.ac.uk/pdbe-srv/view/entry/1VGT PDB 1VGU http://www.ebi.ac.uk/pdbe-srv/view/entry/1VGU PDB 3N9W http://www.ebi.ac.uk/pdbe-srv/view/entry/3N9W PDBsum 1H3M http://www.ebi.ac.uk/pdbsum/1H3M PDBsum 1I52 http://www.ebi.ac.uk/pdbsum/1I52 PDBsum 1INI http://www.ebi.ac.uk/pdbsum/1INI PDBsum 1INJ http://www.ebi.ac.uk/pdbsum/1INJ PDBsum 1VGT http://www.ebi.ac.uk/pdbsum/1VGT PDBsum 1VGU http://www.ebi.ac.uk/pdbsum/1VGU PDBsum 3N9W http://www.ebi.ac.uk/pdbsum/3N9W PROSITE PS01295 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01295 PSORT swissprot:ISPD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ISPD_ECOLI PSORT-B swissprot:ISPD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ISPD_ECOLI PSORT2 swissprot:ISPD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ISPD_ECOLI Pfam PF01128 http://pfam.xfam.org/family/PF01128 Phobius swissprot:ISPD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ISPD_ECOLI PhylomeDB Q46893 http://phylomedb.org/?seqid=Q46893 ProteinModelPortal Q46893 http://www.proteinmodelportal.org/query/uniprot/Q46893 PubMed 10518523 http://www.ncbi.nlm.nih.gov/pubmed/10518523 PubMed 11427897 http://www.ncbi.nlm.nih.gov/pubmed/11427897 PubMed 11468415 http://www.ncbi.nlm.nih.gov/pubmed/11468415 PubMed 12595740 http://www.ncbi.nlm.nih.gov/pubmed/12595740 PubMed 12859972 http://www.ncbi.nlm.nih.gov/pubmed/12859972 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417227 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417227 RefSeq WP_000246138 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000246138 SMR Q46893 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46893 STRING 511145.b2747 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2747&targetmode=cogs STRING COG1211 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1211&targetmode=cogs SUPFAM SSF53448 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53448 TIGRFAMs TIGR00453 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00453 UniProtKB ISPD_ECOLI http://www.uniprot.org/uniprot/ISPD_ECOLI UniProtKB-AC Q46893 http://www.uniprot.org/uniprot/Q46893 charge swissprot:ISPD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ISPD_ECOLI eggNOG COG1211 http://eggnogapi.embl.de/nog_data/html/tree/COG1211 eggNOG ENOG4105CE5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CE5 epestfind swissprot:ISPD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ISPD_ECOLI garnier swissprot:ISPD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ISPD_ECOLI helixturnhelix swissprot:ISPD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ISPD_ECOLI hmoment swissprot:ISPD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ISPD_ECOLI iep swissprot:ISPD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ISPD_ECOLI inforesidue swissprot:ISPD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ISPD_ECOLI octanol swissprot:ISPD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ISPD_ECOLI pepcoil swissprot:ISPD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ISPD_ECOLI pepdigest swissprot:ISPD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ISPD_ECOLI pepinfo swissprot:ISPD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ISPD_ECOLI pepnet swissprot:ISPD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ISPD_ECOLI pepstats swissprot:ISPD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ISPD_ECOLI pepwheel swissprot:ISPD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ISPD_ECOLI pepwindow swissprot:ISPD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ISPD_ECOLI sigcleave swissprot:ISPD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ISPD_ECOLI ## Database ID URL or Descriptions # BioGrid 4263078 9 # EcoGene EG12952 glcG # InterPro IPR005624 Haem_degrading # Organism GLCG_ECOLI Escherichia coli (strain K12) # PATRIC 32121368 VBIEscCol129921_3071 # PIR G65083 G65083 # Pfam PF03928 Haem_degrading # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLCG_ECOLI Protein GlcG # RefSeq NP_417451 NC_000913.3 # RefSeq WP_000853256 NZ_LN832404.1 # SIMILARITY Belongs to the GlcG family. {ECO 0000305}. # eggNOG COG3193 LUCA # eggNOG ENOG4108ZJF Bacteria BLAST swissprot:GLCG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLCG_ECOLI BioCyc ECOL316407:JW2944-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2944-MONOMER BioCyc EcoCyc:G7543-MONOMER http://biocyc.org/getid?id=EcoCyc:G7543-MONOMER COG COG3193 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3193 DIP DIP-9766N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9766N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1432-1033.1994.00541.x http://dx.doi.org/10.1111/j.1432-1033.1994.00541.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L43490 http://www.ebi.ac.uk/ena/data/view/L43490 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EMBL X74547 http://www.ebi.ac.uk/ena/data/view/X74547 EchoBASE EB2786 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2786 EcoGene EG12952 http://www.ecogene.org/geneInfo.php?eg_id=EG12952 EnsemblBacteria AAC76013 http://www.ensemblgenomes.org/id/AAC76013 EnsemblBacteria AAC76013 http://www.ensemblgenomes.org/id/AAC76013 EnsemblBacteria BAE77037 http://www.ensemblgenomes.org/id/BAE77037 EnsemblBacteria BAE77037 http://www.ensemblgenomes.org/id/BAE77037 EnsemblBacteria BAE77037 http://www.ensemblgenomes.org/id/BAE77037 EnsemblBacteria b2977 http://www.ensemblgenomes.org/id/b2977 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947473 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947473 HOGENOM HOG000195937 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000195937&db=HOGENOM6 InParanoid P0AEQ1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEQ1 InterPro IPR005624 http://www.ebi.ac.uk/interpro/entry/IPR005624 KEGG_Gene ecj:JW2944 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2944 KEGG_Gene eco:b2977 http://www.genome.jp/dbget-bin/www_bget?eco:b2977 KEGG_Orthology KO:K11477 http://www.genome.jp/dbget-bin/www_bget?KO:K11477 OMA EDMINNG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EDMINNG PSORT swissprot:GLCG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLCG_ECOLI PSORT-B swissprot:GLCG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLCG_ECOLI PSORT2 swissprot:GLCG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLCG_ECOLI Pfam PF03928 http://pfam.xfam.org/family/PF03928 Phobius swissprot:GLCG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLCG_ECOLI PhylomeDB P0AEQ1 http://phylomedb.org/?seqid=P0AEQ1 ProteinModelPortal P0AEQ1 http://www.proteinmodelportal.org/query/uniprot/P0AEQ1 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7925370 http://www.ncbi.nlm.nih.gov/pubmed/7925370 PubMed 8606183 http://www.ncbi.nlm.nih.gov/pubmed/8606183 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417451 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417451 RefSeq WP_000853256 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000853256 SMR P0AEQ1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEQ1 STRING 511145.b2977 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2977&targetmode=cogs STRING COG3193 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3193&targetmode=cogs UniProtKB GLCG_ECOLI http://www.uniprot.org/uniprot/GLCG_ECOLI UniProtKB-AC P0AEQ1 http://www.uniprot.org/uniprot/P0AEQ1 charge swissprot:GLCG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLCG_ECOLI eggNOG COG3193 http://eggnogapi.embl.de/nog_data/html/tree/COG3193 eggNOG ENOG4108ZJF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZJF epestfind swissprot:GLCG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLCG_ECOLI garnier swissprot:GLCG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLCG_ECOLI helixturnhelix swissprot:GLCG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLCG_ECOLI hmoment swissprot:GLCG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLCG_ECOLI iep swissprot:GLCG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLCG_ECOLI inforesidue swissprot:GLCG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLCG_ECOLI octanol swissprot:GLCG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLCG_ECOLI pepcoil swissprot:GLCG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLCG_ECOLI pepdigest swissprot:GLCG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLCG_ECOLI pepinfo swissprot:GLCG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLCG_ECOLI pepnet swissprot:GLCG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLCG_ECOLI pepstats swissprot:GLCG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLCG_ECOLI pepwheel swissprot:GLCG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLCG_ECOLI pepwindow swissprot:GLCG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLCG_ECOLI sigcleave swissprot:GLCG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLCG_ECOLI ## Database ID URL or Descriptions # AltName RLUD_ECOLI 23S rRNA pseudouridine(1911/1915/1917) synthase # AltName RLUD_ECOLI rRNA pseudouridylate synthase D # AltName RLUD_ECOLI rRNA-uridine isomerase D # BRENDA 5.4.99.23 2026 # BioGrid 4263197 29 # CATALYTIC ACTIVITY RLUD_ECOLI 23S rRNA uridine(1911)/uridine(1915)/uridine(1917) = 23S rRNA pseudouridine(1911)/pseudouridine(1915)/pseudouridine(1917). {ECO 0000269|PubMed 11087118, ECO 0000269|PubMed 17937767}. # EcoGene EG12098 rluD # FUNCTION RLUD_ECOLI Responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA. Isomerization occurs as a late step during the assembly of the large ribosomal subunit. {ECO 0000269|PubMed 11087118, ECO 0000269|PubMed 17937767}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003723 RNA binding; IEA:UniProtKB-KW. # GO_function GO:0009982 pseudouridine synthase activity; IDA:EcoCyc. # GO_process GO:0000027 ribosomal large subunit assembly; IMP:EcoCyc. # GO_process GO:0000455 enzyme-directed rRNA pseudouridine synthesis; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0022618 ribonucleoprotein complex assembly # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.10.290.10 -; 1. # INTERACTION RLUD_ECOLI P0A8A4 ppsR; NbExp=2; IntAct=EBI-558026, EBI-548302; # IntAct P33643 18 # InterPro IPR002942 S4_RNA-bd # InterPro IPR006145 PsdUridine_synth_RsuA/RluD # InterPro IPR006224 PsdUridine_synth_RluC/D_CS # InterPro IPR006225 PsdUridine_synth_RluC/D # InterPro IPR020103 PsdUridine_synth_cat_dom # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # Organism RLUD_ECOLI Escherichia coli (strain K12) # PATRIC 32120591 VBIEscCol129921_2694 # PDB 1PRZ X-ray; 1.80 A; A=75-326 # PDB 1QYU X-ray; 2.00 A; A=2-326 # PDB 1V9F X-ray; 1.70 A; A=2-326 # PDB 2IST X-ray; 1.86 A; A=2-326 # PIR E65037 E65037 # PROSITE PS01129 PSI_RLU # PROSITE PS50889 S4 # Pfam PF00849 PseudoU_synth_2 # Pfam PF01479 S4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RLUD_ECOLI Ribosomal large subunit pseudouridine synthase D # RefSeq NP_417085 NC_000913.3 # RefSeq WP_000079100 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=X57620; Type=Frameshift; Positions=134; Evidence={ECO 0000305}; # SIMILARITY Belongs to the pseudouridine synthase RluA family. {ECO 0000305}. # SIMILARITY Contains 1 S4 RNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00182}. # SMART SM00363 S4 # SUPFAM SSF55120 SSF55120 # TIGRFAMs TIGR00005 rluA_subfam # eggNOG COG0564 LUCA # eggNOG ENOG4105C34 Bacteria BLAST swissprot:RLUD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RLUD_ECOLI BioCyc ECOL316407:JW2576-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2576-MONOMER BioCyc EcoCyc:EG12098-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12098-MONOMER BioCyc MetaCyc:EG12098-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12098-MONOMER COG COG0564 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0564 DIP DIP-10721N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10721N DOI 10.1017/S1355838201000243 http://dx.doi.org/10.1017/S1355838201000243 DOI 10.1017/S1355838298981146 http://dx.doi.org/10.1017/S1355838298981146 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1080/15216540050176566 http://dx.doi.org/10.1080/15216540050176566 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1742-4658.2007.06101.x http://dx.doi.org/10.1111/j.1742-4658.2007.06101.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.4.99.23 http://www.genome.jp/dbget-bin/www_bget?EC:5.4.99.23 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U50134 http://www.ebi.ac.uk/ena/data/view/U50134 EMBL X57620 http://www.ebi.ac.uk/ena/data/view/X57620 ENZYME 5.4.99.23 http://enzyme.expasy.org/EC/5.4.99.23 EchoBASE EB2022 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2022 EcoGene EG12098 http://www.ecogene.org/geneInfo.php?eg_id=EG12098 EnsemblBacteria AAC75643 http://www.ensemblgenomes.org/id/AAC75643 EnsemblBacteria AAC75643 http://www.ensemblgenomes.org/id/AAC75643 EnsemblBacteria BAA16479 http://www.ensemblgenomes.org/id/BAA16479 EnsemblBacteria BAA16479 http://www.ensemblgenomes.org/id/BAA16479 EnsemblBacteria BAA16479 http://www.ensemblgenomes.org/id/BAA16479 EnsemblBacteria b2594 http://www.ensemblgenomes.org/id/b2594 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0009982 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009982 GO_process GO:0000027 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000027 GO_process GO:0000455 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000455 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0022618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022618 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.10.290.10 http://www.cathdb.info/version/latest/superfamily/3.10.290.10 GeneID 947087 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947087 HOGENOM HOG000275919 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275919&db=HOGENOM6 InParanoid P33643 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33643 IntAct P33643 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33643* IntEnz 5.4.99.23 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.4.99.23 InterPro IPR002942 http://www.ebi.ac.uk/interpro/entry/IPR002942 InterPro IPR006145 http://www.ebi.ac.uk/interpro/entry/IPR006145 InterPro IPR006224 http://www.ebi.ac.uk/interpro/entry/IPR006224 InterPro IPR006225 http://www.ebi.ac.uk/interpro/entry/IPR006225 InterPro IPR020103 http://www.ebi.ac.uk/interpro/entry/IPR020103 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW2576 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2576 KEGG_Gene eco:b2594 http://www.genome.jp/dbget-bin/www_bget?eco:b2594 KEGG_Orthology KO:K06180 http://www.genome.jp/dbget-bin/www_bget?KO:K06180 OMA SRIYECI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SRIYECI PDB 1PRZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1PRZ PDB 1QYU http://www.ebi.ac.uk/pdbe-srv/view/entry/1QYU PDB 1V9F http://www.ebi.ac.uk/pdbe-srv/view/entry/1V9F PDB 2IST http://www.ebi.ac.uk/pdbe-srv/view/entry/2IST PDBsum 1PRZ http://www.ebi.ac.uk/pdbsum/1PRZ PDBsum 1QYU http://www.ebi.ac.uk/pdbsum/1QYU PDBsum 1V9F http://www.ebi.ac.uk/pdbsum/1V9F PDBsum 2IST http://www.ebi.ac.uk/pdbsum/2IST PROSITE PS01129 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01129 PROSITE PS50889 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50889 PSORT swissprot:RLUD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RLUD_ECOLI PSORT-B swissprot:RLUD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RLUD_ECOLI PSORT2 swissprot:RLUD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RLUD_ECOLI Pfam PF00849 http://pfam.xfam.org/family/PF00849 Pfam PF01479 http://pfam.xfam.org/family/PF01479 Phobius swissprot:RLUD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RLUD_ECOLI PhylomeDB P33643 http://phylomedb.org/?seqid=P33643 ProteinModelPortal P33643 http://www.proteinmodelportal.org/query/uniprot/P33643 PubMed 11087118 http://www.ncbi.nlm.nih.gov/pubmed/11087118 PubMed 11453071 http://www.ncbi.nlm.nih.gov/pubmed/11453071 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17937767 http://www.ncbi.nlm.nih.gov/pubmed/17937767 PubMed 1906060 http://www.ncbi.nlm.nih.gov/pubmed/1906060 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9814761 http://www.ncbi.nlm.nih.gov/pubmed/9814761 RefSeq NP_417085 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417085 RefSeq WP_000079100 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000079100 SMART SM00363 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00363 SMR P33643 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33643 STRING 511145.b2594 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2594&targetmode=cogs STRING COG0564 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0564&targetmode=cogs SUPFAM SSF55120 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55120 TIGRFAMs TIGR00005 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00005 UniProtKB RLUD_ECOLI http://www.uniprot.org/uniprot/RLUD_ECOLI UniProtKB-AC P33643 http://www.uniprot.org/uniprot/P33643 charge swissprot:RLUD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RLUD_ECOLI eggNOG COG0564 http://eggnogapi.embl.de/nog_data/html/tree/COG0564 eggNOG ENOG4105C34 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C34 epestfind swissprot:RLUD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RLUD_ECOLI garnier swissprot:RLUD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RLUD_ECOLI helixturnhelix swissprot:RLUD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RLUD_ECOLI hmoment swissprot:RLUD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RLUD_ECOLI iep swissprot:RLUD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RLUD_ECOLI inforesidue swissprot:RLUD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RLUD_ECOLI octanol swissprot:RLUD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RLUD_ECOLI pepcoil swissprot:RLUD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RLUD_ECOLI pepdigest swissprot:RLUD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RLUD_ECOLI pepinfo swissprot:RLUD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RLUD_ECOLI pepnet swissprot:RLUD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RLUD_ECOLI pepstats swissprot:RLUD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RLUD_ECOLI pepwheel swissprot:RLUD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RLUD_ECOLI pepwindow swissprot:RLUD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RLUD_ECOLI sigcleave swissprot:RLUD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RLUD_ECOLI ## Database ID URL or Descriptions # AltName NARJ_ECOLI Redox enzyme maturation protein NarJ # BRENDA 1.7.5 2026 # BioGrid 4262232 7 # EcoGene EG10641 narJ # FUNCTION NARJ_ECOLI Chaperone required for proper molybdenum cofactor insertion and final assembly of the membrane-bound respiratory nitrate reductase 1. Required for the insertion of the molybdenum into the apo-NarG subunit, maybe by keeping NarG in an appropriate competent-open conformation for the molybdenum cofactor insertion to occur. NarJ maintains the apoNarGH complex in a soluble state. Upon insertion of the molybdenum cofactor, NarJ seems to dissociate from the activated soluble NarGH complex, before its association with the NarI subunit on the membrane. {ECO 0000269|PubMed 16286471, ECO 0000269|PubMed 1732220, ECO 0000269|PubMed 9305880, ECO 0000269|PubMed 9632249}. # GO_component GO:0005737 cytoplasm; IDA:UniProtKB. # GO_function GO:0016530 metallochaperone activity; IMP:EcoCyc. # GO_process GO:0042128 nitrate assimilation; IDA:UniProtKB. # GO_process GO:0051131 chaperone-mediated protein complex assembly; IDA:UniProtKB. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0071941 nitrogen cycle metabolic process # Gene3D 1.10.3480.10 -; 1. # INTERACTION NARJ_ECOLI P09152 narG; NbExp=16; IntAct=EBI-555043, EBI-547248; P19319 narZ; NbExp=3; IntAct=EBI-555043, EBI-547262; # IntAct P0AF26 11 # InterPro IPR003765 NO3_reductase_chaperone_NarJ # InterPro IPR020945 DMSO/NO3_reduct_chaperone # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Pathway ko00910 Nitrogen metabolism # KEGG_Pathway ko02020 Two-component system # Organism NARJ_ECOLI Escherichia coli (strain K12) # PATRIC 32117712 VBIEscCol129921_1278 # PIR B27737 BVECJ # Pfam PF02613 Nitrate_red_del # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NARJ_ECOLI Nitrate reductase molybdenum cofactor assembly chaperone NarJ # RefSeq NP_415744 NC_000913.3 # RefSeq WP_000571681 NZ_LN832404.1 # SIMILARITY Belongs to the NarJ/NarW family. {ECO 0000305}. # SUBCELLULAR LOCATION NARJ_ECOLI Cytoplasm {ECO 0000269|PubMed 9305880}. # SUBUNIT NARJ_ECOLI Binds specifically to the NarG subunit of the apoenzyme complex at two distinct sites, one interfering with membrane anchoring and another being involved in molybdenum insertion. {ECO 0000269|PubMed 16286471, ECO 0000269|PubMed 9305880, ECO 0000269|PubMed 9632249}. # SUPFAM SSF89155 SSF89155 # TIGRFAMs TIGR00684 narJ # eggNOG COG2180 LUCA # eggNOG ENOG4105R3A Bacteria BLAST swissprot:NARJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NARJ_ECOLI BioCyc ECOL316407:JW1217-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1217-MONOMER BioCyc EcoCyc:NARJ-MONOMER http://biocyc.org/getid?id=EcoCyc:NARJ-MONOMER COG COG2180 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2180 DIP DIP-35943N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35943N DOI 10.1007/BF00331275 http://dx.doi.org/10.1007/BF00331275 DOI 10.1016/j.bbrc.2006.02.133 http://dx.doi.org/10.1016/j.bbrc.2006.02.133 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1998.00795.x http://dx.doi.org/10.1046/j.1365-2958.1998.00795.x DOI 10.1074/jbc.272.39.24266 http://dx.doi.org/10.1074/jbc.272.39.24266 DOI 10.1074/jbc.M505902200 http://dx.doi.org/10.1074/jbc.M505902200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1742-4658.2010.07611.x http://dx.doi.org/10.1111/j.1742-4658.2010.07611.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M20147 http://www.ebi.ac.uk/ena/data/view/M20147 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X16181 http://www.ebi.ac.uk/ena/data/view/X16181 EchoBASE EB0635 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0635 EcoGene EG10641 http://www.ecogene.org/geneInfo.php?eg_id=EG10641 EnsemblBacteria AAC74310 http://www.ensemblgenomes.org/id/AAC74310 EnsemblBacteria AAC74310 http://www.ensemblgenomes.org/id/AAC74310 EnsemblBacteria BAA36096 http://www.ensemblgenomes.org/id/BAA36096 EnsemblBacteria BAA36096 http://www.ensemblgenomes.org/id/BAA36096 EnsemblBacteria BAA36096 http://www.ensemblgenomes.org/id/BAA36096 EnsemblBacteria b1226 http://www.ensemblgenomes.org/id/b1226 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0016530 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016530 GO_process GO:0042128 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042128 GO_process GO:0051131 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051131 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0071941 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071941 Gene3D 1.10.3480.10 http://www.cathdb.info/version/latest/superfamily/1.10.3480.10 GeneID 945807 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945807 HOGENOM HOG000237365 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000237365&db=HOGENOM6 InParanoid P0AF26 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AF26 IntAct P0AF26 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AF26* InterPro IPR003765 http://www.ebi.ac.uk/interpro/entry/IPR003765 InterPro IPR020945 http://www.ebi.ac.uk/interpro/entry/IPR020945 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Gene ecj:JW1217 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1217 KEGG_Gene eco:b1226 http://www.genome.jp/dbget-bin/www_bget?eco:b1226 KEGG_Orthology KO:K00373 http://www.genome.jp/dbget-bin/www_bget?KO:K00373 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 KEGG_Reaction rn:R00798 http://www.genome.jp/dbget-bin/www_bget?rn:R00798 KEGG_Reaction rn:R01106 http://www.genome.jp/dbget-bin/www_bget?rn:R01106 MINT MINT-1243008 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1243008 OMA CELFDRG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CELFDRG PSORT swissprot:NARJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NARJ_ECOLI PSORT-B swissprot:NARJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NARJ_ECOLI PSORT2 swissprot:NARJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NARJ_ECOLI Pfam PF02613 http://pfam.xfam.org/family/PF02613 Phobius swissprot:NARJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NARJ_ECOLI PhylomeDB P0AF26 http://phylomedb.org/?seqid=P0AF26 ProteinModelPortal P0AF26 http://www.proteinmodelportal.org/query/uniprot/P0AF26 PubMed 16286471 http://www.ncbi.nlm.nih.gov/pubmed/16286471 PubMed 16540088 http://www.ncbi.nlm.nih.gov/pubmed/16540088 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1732220 http://www.ncbi.nlm.nih.gov/pubmed/1732220 PubMed 20236317 http://www.ncbi.nlm.nih.gov/pubmed/20236317 PubMed 2674654 http://www.ncbi.nlm.nih.gov/pubmed/2674654 PubMed 2832376 http://www.ncbi.nlm.nih.gov/pubmed/2832376 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9305880 http://www.ncbi.nlm.nih.gov/pubmed/9305880 PubMed 9632249 http://www.ncbi.nlm.nih.gov/pubmed/9632249 RefSeq NP_415744 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415744 RefSeq WP_000571681 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000571681 STRING 511145.b1226 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1226&targetmode=cogs STRING COG2180 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2180&targetmode=cogs SUPFAM SSF89155 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF89155 TIGRFAMs TIGR00684 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00684 UniProtKB NARJ_ECOLI http://www.uniprot.org/uniprot/NARJ_ECOLI UniProtKB-AC P0AF26 http://www.uniprot.org/uniprot/P0AF26 charge swissprot:NARJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NARJ_ECOLI eggNOG COG2180 http://eggnogapi.embl.de/nog_data/html/tree/COG2180 eggNOG ENOG4105R3A http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105R3A epestfind swissprot:NARJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NARJ_ECOLI garnier swissprot:NARJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NARJ_ECOLI helixturnhelix swissprot:NARJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NARJ_ECOLI hmoment swissprot:NARJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NARJ_ECOLI iep swissprot:NARJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NARJ_ECOLI inforesidue swissprot:NARJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NARJ_ECOLI octanol swissprot:NARJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NARJ_ECOLI pepcoil swissprot:NARJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NARJ_ECOLI pepdigest swissprot:NARJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NARJ_ECOLI pepinfo swissprot:NARJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NARJ_ECOLI pepnet swissprot:NARJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NARJ_ECOLI pepstats swissprot:NARJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NARJ_ECOLI pepwheel swissprot:NARJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NARJ_ECOLI pepwindow swissprot:NARJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NARJ_ECOLI sigcleave swissprot:NARJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NARJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4261885 277 # EcoGene EG11087 secM # FUNCTION SECM_ECOLI Regulates secA expression by translational coupling of the secM secA operon. Ribosomes translating the C-terminal region of secM can disrupt an RNA repressor helix that normally blocks secA translation initiation, derepressing the expression of secA. Translational pausing of secM at Pro-166 under secretion-limiting conditions increases the duration of the disruption and thus increases secA expression. This is controlled by interaction of the secM signal peptide with secA and the translocon, possibly by secA pulling the paused secM out of the ribosome. The arrest sequence (150-FXXXXWIXXXXGIRAGP-166) is sufficient to cause arrest of unrelated proteins. Elongation arrest can be alleviated by mutations in the 23S rRNA or in ribosomal protein L22. # GO_component GO:0005829 cytosol; IEA:UniProtKB-SubCell. # GO_component GO:0042597 periplasmic space; IDA:EcoCyc. # GO_function GO:0045182 translation regulator activity; IDA:EcoCyc. # GO_process GO:0006417 regulation of translation; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0008150 biological_process # HAMAP MF_01332 SecM # InterPro IPR009502 SecM # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02044 M00335 Sec (secretion) system # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko03060 Protein export # KEGG_Pathway ko03070 Bacterial secretion system # Organism SECM_ECOLI Escherichia coli (strain K12) # PATRIC 32115299 VBIEscCol129921_0101 # PDB 2N62 NMR; -; L=150-166 # PDB 3JBV EM; 3.32 A; z=150-166 # PIR A64732 QQECAA # PIRSF PIRSF004572 SecM # Pfam PF06558 SecM # ProDom PD089227 SecM # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SECM_ECOLI Secretion monitor # RefSeq NP_414639 NC_000913.3 # RefSeq WP_000014321 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA24618.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAA83850.1; Type=Erroneous initiation; Evidence={ECO 0000305}; Sequence=CAA38874.1; Type=Erroneous initiation; Evidence={ECO:0000305}; # SIMILARITY Belongs to the SecM family. {ECO 0000305}. # SUBCELLULAR LOCATION SECM_ECOLI Cytoplasm, cytosol {ECO 0000269|PubMed 1834634}. Periplasm {ECO 0000269|PubMed 1834634}. Note=The active form is cytosolic, while the periplasmic form is rapidly degraded, mainly by the tail-specific protease. # eggNOG ENOG4108SR7 Bacteria # eggNOG ENOG4111GJA LUCA BLAST swissprot:SECM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SECM_ECOLI BioCyc ECOL316407:JW5007-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5007-MONOMER BioCyc EcoCyc:EG11087-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11087-MONOMER DOI 10.1016/S0092-8674(02)00649-9 http://dx.doi.org/10.1016/S0092-8674(02)00649-9 DOI 10.1016/S1097-2765(01)00166-6 http://dx.doi.org/10.1016/S1097-2765(01)00166-6 DOI 10.1016/j.mib.2004.01.001 http://dx.doi.org/10.1016/j.mib.2004.01.001 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.19.5592-5595.2000 http://dx.doi.org/10.1128/JB.182.19.5592-5595.2000 DOI 10.1128/JB.184.9.2360-2369.2002 http://dx.doi.org/10.1128/JB.184.9.2360-2369.2002 DOI 10.1128/JB.185.22.6719-6722.2003 http://dx.doi.org/10.1128/JB.185.22.6719-6722.2003 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M19211 http://www.ebi.ac.uk/ena/data/view/M19211 EMBL M20791 http://www.ebi.ac.uk/ena/data/view/M20791 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X55034 http://www.ebi.ac.uk/ena/data/view/X55034 EchoBASE EB1079 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1079 EcoGene EG11087 http://www.ecogene.org/geneInfo.php?eg_id=EG11087 EnsemblBacteria AAC73208 http://www.ensemblgenomes.org/id/AAC73208 EnsemblBacteria AAC73208 http://www.ensemblgenomes.org/id/AAC73208 EnsemblBacteria BAB96665 http://www.ensemblgenomes.org/id/BAB96665 EnsemblBacteria BAB96665 http://www.ensemblgenomes.org/id/BAB96665 EnsemblBacteria BAB96665 http://www.ensemblgenomes.org/id/BAB96665 EnsemblBacteria b0097 http://www.ensemblgenomes.org/id/b0097 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0045182 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045182 GO_process GO:0006417 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006417 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 944831 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944831 HAMAP MF_01332 http://hamap.expasy.org/unirule/MF_01332 HOGENOM HOG000267813 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267813&db=HOGENOM6 IntAct P62395 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P62395* InterPro IPR009502 http://www.ebi.ac.uk/interpro/entry/IPR009502 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW5007 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5007 KEGG_Gene eco:b0097 http://www.genome.jp/dbget-bin/www_bget?eco:b0097 KEGG_Orthology KO:K13301 http://www.genome.jp/dbget-bin/www_bget?KO:K13301 KEGG_Pathway ko03060 http://www.genome.jp/kegg-bin/show_pathway?ko03060 KEGG_Pathway ko03070 http://www.genome.jp/kegg-bin/show_pathway?ko03070 OMA SAWISQV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SAWISQV PDB 2N62 http://www.ebi.ac.uk/pdbe-srv/view/entry/2N62 PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDBsum 2N62 http://www.ebi.ac.uk/pdbsum/2N62 PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PSORT swissprot:SECM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SECM_ECOLI PSORT-B swissprot:SECM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SECM_ECOLI PSORT2 swissprot:SECM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SECM_ECOLI Pfam PF06558 http://pfam.xfam.org/family/PF06558 Phobius swissprot:SECM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SECM_ECOLI ProteinModelPortal P62395 http://www.proteinmodelportal.org/query/uniprot/P62395 PubMed 10986266 http://www.ncbi.nlm.nih.gov/pubmed/10986266 PubMed 11172723 http://www.ncbi.nlm.nih.gov/pubmed/11172723 PubMed 11893334 http://www.ncbi.nlm.nih.gov/pubmed/11893334 PubMed 11948148 http://www.ncbi.nlm.nih.gov/pubmed/11948148 PubMed 14594848 http://www.ncbi.nlm.nih.gov/pubmed/14594848 PubMed 15063851 http://www.ncbi.nlm.nih.gov/pubmed/15063851 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1834634 http://www.ncbi.nlm.nih.gov/pubmed/1834634 PubMed 2824434 http://www.ncbi.nlm.nih.gov/pubmed/2824434 PubMed 2841285 http://www.ncbi.nlm.nih.gov/pubmed/2841285 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9748461 http://www.ncbi.nlm.nih.gov/pubmed/9748461 RefSeq NP_414639 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414639 RefSeq WP_000014321 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000014321 SMR P62395 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P62395 STRING 511145.b0097 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0097&targetmode=cogs UniProtKB SECM_ECOLI http://www.uniprot.org/uniprot/SECM_ECOLI UniProtKB-AC P62395 http://www.uniprot.org/uniprot/P62395 charge swissprot:SECM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SECM_ECOLI eggNOG ENOG4108SR7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108SR7 eggNOG ENOG4111GJA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111GJA epestfind swissprot:SECM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SECM_ECOLI garnier swissprot:SECM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SECM_ECOLI helixturnhelix swissprot:SECM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SECM_ECOLI hmoment swissprot:SECM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SECM_ECOLI iep swissprot:SECM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SECM_ECOLI inforesidue swissprot:SECM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SECM_ECOLI octanol swissprot:SECM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SECM_ECOLI pepcoil swissprot:SECM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SECM_ECOLI pepdigest swissprot:SECM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SECM_ECOLI pepinfo swissprot:SECM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SECM_ECOLI pepnet swissprot:SECM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SECM_ECOLI pepstats swissprot:SECM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SECM_ECOLI pepwheel swissprot:SECM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SECM_ECOLI pepwindow swissprot:SECM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SECM_ECOLI sigcleave swissprot:SECM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SECM_ECOLI ## Database ID URL or Descriptions # BioGrid 4261103 85 # DISRUPTION PHENOTYPE Deletion increases the sensitivity to cystine. {ECO:0000269|PubMed 25346166}. # EcoGene EG11902 yijE # FUNCTION YIJE_ECOLI Involved in response to cystine. Overexpression confers tolerance to excess cystine. {ECO 0000269|PubMed 25346166}. # GO_component GO:0005887 integral component of plasma membrane; ISM:EcoCyc. # GO_function GO:0000099 sulfur amino acid transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0000101 sulfur amino acid transport; IEP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # INDUCTION Up-regulated by cystine. {ECO:0000269|PubMed 25346166}. # InterPro IPR000620 EamA_dom # Organism YIJE_ECOLI Escherichia coli (strain K12) # PATRIC 32123407 VBIEscCol129921_4064 # PIR I78664 I78664 # Pfam PF00892 EamA; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Probable cystine transporter YijE {ECO 0000305} # RefSeq NP_418378 NC_000913.3 # RefSeq WP_001271242 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAC43049.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the EamA transporter family. {ECO 0000305}. # SIMILARITY Contains 2 EamA domains. {ECO 0000255}. # SUBCELLULAR LOCATION YIJE_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255}. # eggNOG ENOG4108Q5Y Bacteria # eggNOG ENOG410Y0KE LUCA BLAST swissprot:YIJE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIJE_ECOLI BioCyc ECOL316407:JW5557-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5557-MONOMER BioCyc EcoCyc:EG11902-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11902-MONOMER BioCyc MetaCyc:EG11902-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11902-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1080/09168451.2014.972328 http://dx.doi.org/10.1080/09168451.2014.972328 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1847 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1847 EcoGene EG11902 http://www.ecogene.org/geneInfo.php?eg_id=EG11902 EnsemblBacteria AAC76925 http://www.ensemblgenomes.org/id/AAC76925 EnsemblBacteria AAC76925 http://www.ensemblgenomes.org/id/AAC76925 EnsemblBacteria BAE77367 http://www.ensemblgenomes.org/id/BAE77367 EnsemblBacteria BAE77367 http://www.ensemblgenomes.org/id/BAE77367 EnsemblBacteria BAE77367 http://www.ensemblgenomes.org/id/BAE77367 EnsemblBacteria b3943 http://www.ensemblgenomes.org/id/b3943 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0000099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000099 GO_process GO:0000101 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000101 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948445 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948445 HOGENOM HOG000277404 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000277404&db=HOGENOM6 InParanoid P0ABT8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABT8 InterPro IPR000620 http://www.ebi.ac.uk/interpro/entry/IPR000620 KEGG_Gene ecj:JW5557 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5557 KEGG_Gene eco:b3943 http://www.genome.jp/dbget-bin/www_bget?eco:b3943 OMA WIVMLIR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WIVMLIR PSORT swissprot:YIJE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIJE_ECOLI PSORT-B swissprot:YIJE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIJE_ECOLI PSORT2 swissprot:YIJE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIJE_ECOLI Pfam PF00892 http://pfam.xfam.org/family/PF00892 Phobius swissprot:YIJE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIJE_ECOLI PhylomeDB P0ABT8 http://phylomedb.org/?seqid=P0ABT8 ProteinModelPortal P0ABT8 http://www.proteinmodelportal.org/query/uniprot/P0ABT8 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 25346166 http://www.ncbi.nlm.nih.gov/pubmed/25346166 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418378 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418378 RefSeq WP_001271242 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001271242 STRING 511145.b3943 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3943&targetmode=cogs UniProtKB YIJE_ECOLI http://www.uniprot.org/uniprot/YIJE_ECOLI UniProtKB-AC P0ABT8 http://www.uniprot.org/uniprot/P0ABT8 charge swissprot:YIJE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIJE_ECOLI eggNOG ENOG4108Q5Y http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Q5Y eggNOG ENOG410Y0KE http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y0KE epestfind swissprot:YIJE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIJE_ECOLI garnier swissprot:YIJE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIJE_ECOLI helixturnhelix swissprot:YIJE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIJE_ECOLI hmoment swissprot:YIJE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIJE_ECOLI iep swissprot:YIJE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIJE_ECOLI inforesidue swissprot:YIJE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIJE_ECOLI octanol swissprot:YIJE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIJE_ECOLI pepcoil swissprot:YIJE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIJE_ECOLI pepdigest swissprot:YIJE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIJE_ECOLI pepinfo swissprot:YIJE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIJE_ECOLI pepnet swissprot:YIJE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIJE_ECOLI pepstats swissprot:YIJE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIJE_ECOLI pepwheel swissprot:YIJE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIJE_ECOLI pepwindow swissprot:YIJE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIJE_ECOLI sigcleave swissprot:YIJE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIJE_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES GARD_ECOLI Kinetic parameters KM=800 uM for galactarate {ECO 0000269|PubMed 9772162}; Note=kcat is 22 sec(-1). {ECO 0000269|PubMed 9772162}; # BioGrid 4259485 17 # CATALYTIC ACTIVITY GARD_ECOLI Galactarate = (2R,3S)-2,3-dihydroxy-5- oxohexanedioate + H(2)O. {ECO 0000255|HAMAP-Rule MF_02031, ECO 0000269|PubMed 9772162}. # EcoGene EG12522 garD # FUNCTION GARD_ECOLI Catalyzes the dehydration of galactarate to form 5- dehydro-4-deoxy-D-glucarate. {ECO 0000255|HAMAP-Rule MF_02031, ECO 0000269|PubMed 9772162}. # GO_function GO:0008867 galactarate dehydratase activity; IDA:EcoCyc. # GO_process GO:0046392 galactarate catabolic process; IDA:EcoCyc. # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # HAMAP MF_02031 Galactar_dehydrat # INDUCTION Induced by galactarate, D-glucarate and D-glycerate. {ECO:0000269|PubMed 10762278}. # IntAct P39829 5 # InterPro IPR007392 Gal/Altron_deHydtase_C # InterPro IPR013974 SAF # InterPro IPR017654 GarD-like # InterPro IPR032893 GarD_Enterobacteriaceae # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00053 Ascorbate and aldarate metabolism # Organism GARD_ECOLI Escherichia coli (strain K12) # PATHWAY GARD_ECOLI Carbohydrate acid metabolism; galactarate degradation; D- glycerate from galactarate step 1/3. {ECO 0000255|HAMAP- Rule MF_02031, ECO 0000269|PubMed 9772162}. # PATRIC 32121672 VBIEscCol129921_3222 # PDB 3LAZ X-ray; 1.92 A; A/B=6-96 # PIR D65102 D65102 # Pfam PF04295 GD_AH_C # Pfam PF08666 SAF # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GARD_ECOLI Galactarate dehydratase (L-threo-forming) {ECO 0000255|HAMAP-Rule MF_02031, ECO 0000303|PubMed 9772162} # RefSeq NP_417597 NC_000913.3 # RefSeq WP_001273753 NZ_CP014272.1 # SIMILARITY Belongs to the UxaA family. {ECO:0000255|HAMAP- Rule MF_02031, ECO:0000305}. # SMART SM00858 SAF # TIGRFAMs TIGR03248 galactar-dH20 # UniPathway UPA00565 UER00629 # eggNOG COG2721 LUCA # eggNOG ENOG4105CTX Bacteria BLAST swissprot:GARD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GARD_ECOLI BioCyc ECOL316407:JW3097-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3097-MONOMER BioCyc EcoCyc:GALACTARDEHYDRA-MONOMER http://biocyc.org/getid?id=EcoCyc:GALACTARDEHYDRA-MONOMER BioCyc MetaCyc:GALACTARDEHYDRA-MONOMER http://biocyc.org/getid?id=MetaCyc:GALACTARDEHYDRA-MONOMER COG COG2721 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2721 DOI 10.1021/bi981124f http://dx.doi.org/10.1021/bi981124f DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.9.2672-2674.2000 http://dx.doi.org/10.1128/JB.182.9.2672-2674.2000 EC_number EC:4.2.1.42 {ECO:0000255|HAMAP-Rule:MF_02031, ECO:0000269|PubMed:9772162} http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.42 {ECO:0000255|HAMAP-Rule:MF_02031, ECO:0000269|PubMed:9772162} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M30178 http://www.ebi.ac.uk/ena/data/view/M30178 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 4.2.1.42 {ECO:0000255|HAMAP-Rule:MF_02031, ECO:0000269|PubMed:9772162} http://enzyme.expasy.org/EC/4.2.1.42 {ECO:0000255|HAMAP-Rule:MF_02031, ECO:0000269|PubMed:9772162} EchoBASE EB2413 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2413 EcoGene EG12522 http://www.ecogene.org/geneInfo.php?eg_id=EG12522 EnsemblBacteria AAC76162 http://www.ensemblgenomes.org/id/AAC76162 EnsemblBacteria AAC76162 http://www.ensemblgenomes.org/id/AAC76162 EnsemblBacteria BAE77175 http://www.ensemblgenomes.org/id/BAE77175 EnsemblBacteria BAE77175 http://www.ensemblgenomes.org/id/BAE77175 EnsemblBacteria BAE77175 http://www.ensemblgenomes.org/id/BAE77175 EnsemblBacteria b3128 http://www.ensemblgenomes.org/id/b3128 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008867 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008867 GO_process GO:0046392 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046392 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 947641 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947641 HAMAP MF_02031 http://hamap.expasy.org/unirule/MF_02031 HOGENOM HOG000219063 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219063&db=HOGENOM6 InParanoid P39829 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39829 IntAct P39829 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39829* IntEnz 4.2.1.42 {ECO:0000255|HAMAP-Rule:MF_02031, ECO:0000269|PubMed:9772162} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.42 {ECO:0000255|HAMAP-Rule:MF_02031, ECO:0000269|PubMed:9772162} InterPro IPR007392 http://www.ebi.ac.uk/interpro/entry/IPR007392 InterPro IPR013974 http://www.ebi.ac.uk/interpro/entry/IPR013974 InterPro IPR017654 http://www.ebi.ac.uk/interpro/entry/IPR017654 InterPro IPR032893 http://www.ebi.ac.uk/interpro/entry/IPR032893 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3097 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3097 KEGG_Gene eco:b3128 http://www.genome.jp/dbget-bin/www_bget?eco:b3128 KEGG_Orthology KO:K01708 http://www.genome.jp/dbget-bin/www_bget?KO:K01708 KEGG_Pathway ko00053 http://www.genome.jp/kegg-bin/show_pathway?ko00053 KEGG_Reaction rn:R05608 http://www.genome.jp/dbget-bin/www_bget?rn:R05608 OMA HSYGCGV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HSYGCGV PDB 3LAZ http://www.ebi.ac.uk/pdbe-srv/view/entry/3LAZ PDBsum 3LAZ http://www.ebi.ac.uk/pdbsum/3LAZ PSORT swissprot:GARD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GARD_ECOLI PSORT-B swissprot:GARD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GARD_ECOLI PSORT2 swissprot:GARD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GARD_ECOLI Pfam PF04295 http://pfam.xfam.org/family/PF04295 Pfam PF08666 http://pfam.xfam.org/family/PF08666 Phobius swissprot:GARD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GARD_ECOLI PhylomeDB P39829 http://phylomedb.org/?seqid=P39829 ProteinModelPortal P39829 http://www.proteinmodelportal.org/query/uniprot/P39829 PubMed 10762278 http://www.ncbi.nlm.nih.gov/pubmed/10762278 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2407727 http://www.ncbi.nlm.nih.gov/pubmed/2407727 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9772162 http://www.ncbi.nlm.nih.gov/pubmed/9772162 RefSeq NP_417597 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417597 RefSeq WP_001273753 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001273753 SMART SM00858 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00858 SMR P39829 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39829 STRING 511145.b3128 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3128&targetmode=cogs STRING COG2721 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2721&targetmode=cogs TIGRFAMs TIGR03248 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03248 UniProtKB GARD_ECOLI http://www.uniprot.org/uniprot/GARD_ECOLI UniProtKB-AC P39829 http://www.uniprot.org/uniprot/P39829 charge swissprot:GARD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GARD_ECOLI eggNOG COG2721 http://eggnogapi.embl.de/nog_data/html/tree/COG2721 eggNOG ENOG4105CTX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CTX epestfind swissprot:GARD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GARD_ECOLI garnier swissprot:GARD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GARD_ECOLI helixturnhelix swissprot:GARD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GARD_ECOLI hmoment swissprot:GARD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GARD_ECOLI iep swissprot:GARD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GARD_ECOLI inforesidue swissprot:GARD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GARD_ECOLI octanol swissprot:GARD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GARD_ECOLI pepcoil swissprot:GARD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GARD_ECOLI pepdigest swissprot:GARD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GARD_ECOLI pepinfo swissprot:GARD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GARD_ECOLI pepnet swissprot:GARD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GARD_ECOLI pepstats swissprot:GARD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GARD_ECOLI pepwheel swissprot:GARD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GARD_ECOLI pepwindow swissprot:GARD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GARD_ECOLI sigcleave swissprot:GARD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GARD_ECOLI ## Database ID URL or Descriptions # AltName GLRX4_ECOLI Monothiol glutaredoxin # BioGrid 4260269 433 # CDD cd03028 GRX_PICOT_like # EcoGene EG12181 grxD # FUNCTION GLRX4_ECOLI Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. {ECO 0000305}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0009055 electron carrier activity; IEA:InterPro. # GO_function GO:0015035 protein disulfide oxidoreductase activity; IEA:InterPro. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051537 2 iron, 2 sulfur cluster binding; IDA:EcoCyc. # GO_process GO:0045454 cell redox homeostasis; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0042592 homeostatic process # Gene3D 3.40.30.10 -; 1. # INTERACTION GLRX4_ECOLI P0ABE2 bolA; NbExp=2; IntAct=EBI-545828, EBI-545774; # IntAct P0AC69 18 # InterPro IPR002109 Glutaredoxin # InterPro IPR004480 Monothiol_GRX-rel # InterPro IPR012336 Thioredoxin-like_fold # InterPro IPR014434 Monothiol_GRX # InterPro IPR033658 GRX_PICOT-like # KEGG_Brite ko03110 Chaperones and folding catalysts # Organism GLRX4_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10293 PTHR10293 # PATRIC 32118610 VBIEscCol129921_1725 # PDB 1YKA NMR; -; A=1-115 # PDB 2WCI X-ray; 1.90 A; A/B=1-115 # PIR H64922 H64922 # PIRSF PIRSF005894 Monothiol_GRX # PROSITE PS51354 GLUTAREDOXIN_2 # Pfam PF00462 Glutaredoxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLRX4_ECOLI Glutaredoxin-4 # RefSeq NP_416171 NC_000913.3 # RefSeq WP_000108172 NZ_LN832404.1 # SIMILARITY Belongs to the glutaredoxin family. Monothiol subfamily. {ECO 0000305}. # SIMILARITY Contains 1 glutaredoxin domain. {ECO:0000255|PROSITE- ProRule PRU00686}. # SUBCELLULAR LOCATION GLRX4_ECOLI Cytoplasm {ECO 0000269|PubMed 15833738}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 19505088}. # SUPFAM SSF52833 SSF52833 # TIGRFAMs TIGR00365 TIGR00365 # eggNOG COG0278 LUCA # eggNOG ENOG4105M2J Bacteria BLAST swissprot:GLRX4_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLRX4_ECOLI BioCyc ECOL316407:JW1646-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1646-MONOMER BioCyc EcoCyc:EG12181-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12181-MONOMER COG COG0278 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0278 DIP DIP-11729N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11729N DOI 10.1021/bi900440m http://dx.doi.org/10.1021/bi900440m DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M500678200 http://dx.doi.org/10.1074/jbc.M500678200 DOI 10.1074/jbc.M500679200 http://dx.doi.org/10.1074/jbc.M500679200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L01622 http://www.ebi.ac.uk/ena/data/view/L01622 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2098 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2098 EcoGene EG12181 http://www.ecogene.org/geneInfo.php?eg_id=EG12181 EnsemblBacteria AAC74726 http://www.ensemblgenomes.org/id/AAC74726 EnsemblBacteria AAC74726 http://www.ensemblgenomes.org/id/AAC74726 EnsemblBacteria BAA15420 http://www.ensemblgenomes.org/id/BAA15420 EnsemblBacteria BAA15420 http://www.ensemblgenomes.org/id/BAA15420 EnsemblBacteria BAA15420 http://www.ensemblgenomes.org/id/BAA15420 EnsemblBacteria b1654 http://www.ensemblgenomes.org/id/b1654 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0015035 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015035 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051537 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051537 GO_process GO:0045454 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045454 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 Gene3D 3.40.30.10 http://www.cathdb.info/version/latest/superfamily/3.40.30.10 GeneID 946169 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946169 HOGENOM HOG000095211 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000095211&db=HOGENOM6 InParanoid P0AC69 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AC69 IntAct P0AC69 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AC69* InterPro IPR002109 http://www.ebi.ac.uk/interpro/entry/IPR002109 InterPro IPR004480 http://www.ebi.ac.uk/interpro/entry/IPR004480 InterPro IPR012336 http://www.ebi.ac.uk/interpro/entry/IPR012336 InterPro IPR014434 http://www.ebi.ac.uk/interpro/entry/IPR014434 InterPro IPR033658 http://www.ebi.ac.uk/interpro/entry/IPR033658 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW1646 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1646 KEGG_Gene eco:b1654 http://www.genome.jp/dbget-bin/www_bget?eco:b1654 KEGG_Orthology KO:K07390 http://www.genome.jp/dbget-bin/www_bget?KO:K07390 MINT MINT-1258030 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1258030 OMA HEFIDNE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HEFIDNE PANTHER PTHR10293 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10293 PDB 1YKA http://www.ebi.ac.uk/pdbe-srv/view/entry/1YKA PDB 2WCI http://www.ebi.ac.uk/pdbe-srv/view/entry/2WCI PDBsum 1YKA http://www.ebi.ac.uk/pdbsum/1YKA PDBsum 2WCI http://www.ebi.ac.uk/pdbsum/2WCI PROSITE PS51354 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51354 PSORT swissprot:GLRX4_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLRX4_ECOLI PSORT-B swissprot:GLRX4_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLRX4_ECOLI PSORT2 swissprot:GLRX4_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLRX4_ECOLI Pfam PF00462 http://pfam.xfam.org/family/PF00462 Phobius swissprot:GLRX4_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLRX4_ECOLI PhylomeDB P0AC69 http://phylomedb.org/?seqid=P0AC69 ProteinModelPortal P0AC69 http://www.proteinmodelportal.org/query/uniprot/P0AC69 PubMed 15833738 http://www.ncbi.nlm.nih.gov/pubmed/15833738 PubMed 15840565 http://www.ncbi.nlm.nih.gov/pubmed/15840565 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19505088 http://www.ncbi.nlm.nih.gov/pubmed/19505088 PubMed 7559321 http://www.ncbi.nlm.nih.gov/pubmed/7559321 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416171 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416171 RefSeq WP_000108172 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000108172 SMR P0AC69 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AC69 STRING 511145.b1654 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1654&targetmode=cogs STRING COG0278 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0278&targetmode=cogs SUPFAM SSF52833 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52833 SWISS-2DPAGE P0AC69 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AC69 TIGRFAMs TIGR00365 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00365 UniProtKB GLRX4_ECOLI http://www.uniprot.org/uniprot/GLRX4_ECOLI UniProtKB-AC P0AC69 http://www.uniprot.org/uniprot/P0AC69 charge swissprot:GLRX4_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLRX4_ECOLI eggNOG COG0278 http://eggnogapi.embl.de/nog_data/html/tree/COG0278 eggNOG ENOG4105M2J http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105M2J epestfind swissprot:GLRX4_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLRX4_ECOLI garnier swissprot:GLRX4_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLRX4_ECOLI helixturnhelix swissprot:GLRX4_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLRX4_ECOLI hmoment swissprot:GLRX4_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLRX4_ECOLI iep swissprot:GLRX4_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLRX4_ECOLI inforesidue swissprot:GLRX4_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLRX4_ECOLI octanol swissprot:GLRX4_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLRX4_ECOLI pepcoil swissprot:GLRX4_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLRX4_ECOLI pepdigest swissprot:GLRX4_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLRX4_ECOLI pepinfo swissprot:GLRX4_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLRX4_ECOLI pepnet swissprot:GLRX4_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLRX4_ECOLI pepstats swissprot:GLRX4_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLRX4_ECOLI pepwheel swissprot:GLRX4_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLRX4_ECOLI pepwindow swissprot:GLRX4_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLRX4_ECOLI sigcleave swissprot:GLRX4_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLRX4_ECOLI ## Database ID URL or Descriptions # BioGrid 4259667 7 # EcoGene EG13663 ybgS # InterPro IPR020363 Uncharacterised_YbgS # Organism YBGS_ECOLI Escherichia coli (strain K12) # PATRIC 32116705 VBIEscCol129921_0778 # PIR A64811 A64811 # Pfam PF13985 YbgS # ProDom PD079292 Uncharacterised_YbgS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBGS_ECOLI Uncharacterized protein YbgS # RefSeq NP_415274 NC_000913.3 # RefSeq WP_000784351 NZ_LN832404.1 # eggNOG ENOG4105JND Bacteria # eggNOG ENOG4111NF4 LUCA BLAST swissprot:YBGS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBGS_ECOLI BioCyc ECOL316407:JW0736-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0736-MONOMER BioCyc EcoCyc:G6394-MONOMER http://biocyc.org/getid?id=EcoCyc:G6394-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3427 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3427 EcoGene EG13663 http://www.ecogene.org/geneInfo.php?eg_id=EG13663 EnsemblBacteria AAC73840 http://www.ensemblgenomes.org/id/AAC73840 EnsemblBacteria AAC73840 http://www.ensemblgenomes.org/id/AAC73840 EnsemblBacteria BAA35415 http://www.ensemblgenomes.org/id/BAA35415 EnsemblBacteria BAA35415 http://www.ensemblgenomes.org/id/BAA35415 EnsemblBacteria BAA35415 http://www.ensemblgenomes.org/id/BAA35415 EnsemblBacteria b0753 http://www.ensemblgenomes.org/id/b0753 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945356 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945356 HOGENOM HOG000118035 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118035&db=HOGENOM6 InParanoid P0AAV6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAV6 InterPro IPR020363 http://www.ebi.ac.uk/interpro/entry/IPR020363 KEGG_Gene ecj:JW0736 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0736 KEGG_Gene eco:b0753 http://www.genome.jp/dbget-bin/www_bget?eco:b0753 OMA TMLHPNG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TMLHPNG PSORT swissprot:YBGS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBGS_ECOLI PSORT-B swissprot:YBGS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBGS_ECOLI PSORT2 swissprot:YBGS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBGS_ECOLI Pfam PF13985 http://pfam.xfam.org/family/PF13985 Phobius swissprot:YBGS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBGS_ECOLI ProteinModelPortal P0AAV6 http://www.proteinmodelportal.org/query/uniprot/P0AAV6 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415274 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415274 RefSeq WP_000784351 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000784351 STRING 511145.b0753 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0753&targetmode=cogs UniProtKB YBGS_ECOLI http://www.uniprot.org/uniprot/YBGS_ECOLI UniProtKB-AC P0AAV6 http://www.uniprot.org/uniprot/P0AAV6 charge swissprot:YBGS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBGS_ECOLI eggNOG ENOG4105JND http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105JND eggNOG ENOG4111NF4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111NF4 epestfind swissprot:YBGS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBGS_ECOLI garnier swissprot:YBGS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBGS_ECOLI helixturnhelix swissprot:YBGS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBGS_ECOLI hmoment swissprot:YBGS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBGS_ECOLI iep swissprot:YBGS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBGS_ECOLI inforesidue swissprot:YBGS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBGS_ECOLI octanol swissprot:YBGS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBGS_ECOLI pepcoil swissprot:YBGS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBGS_ECOLI pepdigest swissprot:YBGS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBGS_ECOLI pepinfo swissprot:YBGS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBGS_ECOLI pepnet swissprot:YBGS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBGS_ECOLI pepstats swissprot:YBGS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBGS_ECOLI pepwheel swissprot:YBGS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBGS_ECOLI pepwindow swissprot:YBGS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBGS_ECOLI sigcleave swissprot:YBGS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBGS_ECOLI ## Database ID URL or Descriptions # AltName BCR_ECOLI Sulfonamide resistance protein # BioGrid 4260471 144 # CDD cd06174 MFS # EcoGene EG11419 bcr # FUNCTION BCR_ECOLI Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance (PubMed 2694948). Probable membrane translocase. A transporter able to export peptides. When overexpressed, allows cells deleted for multiple peptidases (pepA, pepB, pepD and pepN) to grow in the presence of dipeptides Ala-Gln or Gly-Tyr which otherwise inhibit growth (PubMed 20067529). Cells overexpressing this protein have decreased intracellular levels of Ala-Gln dipeptide, and in a system that produces the Ala-Gln dipeptide overproduction of this protein increases export of the dipeptide (PubMed 20067529). {ECO 0000269|PubMed 2694948}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015238 drug transmembrane transporter activity; IEA:InterPro. # GO_function GO:0071916 dipeptide transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0015031 protein transport; IEA:UniProtKB-KW. # GO_process GO:0035442 dipeptide transmembrane transport; IMP:EcoCyc. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # GOslim_process GO:0055085 transmembrane transport # InterPro IPR004734 Multidrug-R # InterPro IPR004812 Efflux_drug-R_Bcr/CmlA # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # KEGG_Brite ko02000 Transporters # Organism BCR_ECOLI Escherichia coli (strain K12) # PATRIC 32119719 VBIEscCol129921_2270 # PIR E64987 E64987 # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BCR_ECOLI Bicyclomycin resistance protein # RefSeq NP_416687 NC_000913.3 # RefSeq WP_000213361 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA16406.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA45230.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the major facilitator superfamily. Bcr/CmlA family. {ECO 0000305}. # SUBCELLULAR LOCATION BCR_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000305|PubMed 15919996}. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.2 the major facilitator superfamily (mfs) # TIGRFAMs TIGR00710 efflux_Bcr_CflA # TIGRFAMs TIGR00880 2_A_01_02 # eggNOG ENOG4105C2C Bacteria # eggNOG ENOG410XNNX LUCA BLAST swissprot:BCR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BCR_ECOLI BioCyc ECOL316407:JW5363-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5363-MONOMER BioCyc EcoCyc:BCR-MONOMER http://biocyc.org/getid?id=EcoCyc:BCR-MONOMER COG COG0477 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0477 DOI 10.1016/0378-1119(93)90625-D http://dx.doi.org/10.1016/0378-1119(93)90625-D DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1574-6968.2009.01879.x http://dx.doi.org/10.1111/j.1574-6968.2009.01879.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AAC.33.12.2042 http://dx.doi.org/10.1128/AAC.33.12.2042 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00008 http://www.ebi.ac.uk/ena/data/view/U00008 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X63703 http://www.ebi.ac.uk/ena/data/view/X63703 EchoBASE EB1390 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1390 EcoGene EG11419 http://www.ecogene.org/geneInfo.php?eg_id=EG11419 EnsemblBacteria AAC75243 http://www.ensemblgenomes.org/id/AAC75243 EnsemblBacteria AAC75243 http://www.ensemblgenomes.org/id/AAC75243 EnsemblBacteria BAE76647 http://www.ensemblgenomes.org/id/BAE76647 EnsemblBacteria BAE76647 http://www.ensemblgenomes.org/id/BAE76647 EnsemblBacteria BAE76647 http://www.ensemblgenomes.org/id/BAE76647 EnsemblBacteria b2182 http://www.ensemblgenomes.org/id/b2182 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015238 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015238 GO_function GO:0071916 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071916 GO_process GO:0015031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031 GO_process GO:0035442 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035442 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 944808 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944808 HOGENOM HOG000143171 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000143171&db=HOGENOM6 InParanoid P28246 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P28246 InterPro IPR004734 http://www.ebi.ac.uk/interpro/entry/IPR004734 InterPro IPR004812 http://www.ebi.ac.uk/interpro/entry/IPR004812 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5363 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5363 KEGG_Gene eco:b2182 http://www.genome.jp/dbget-bin/www_bget?eco:b2182 KEGG_Orthology KO:K07552 http://www.genome.jp/dbget-bin/www_bget?KO:K07552 OMA ITHARKG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ITHARKG PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:BCR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BCR_ECOLI PSORT-B swissprot:BCR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BCR_ECOLI PSORT2 swissprot:BCR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BCR_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:BCR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BCR_ECOLI PhylomeDB P28246 http://phylomedb.org/?seqid=P28246 ProteinModelPortal P28246 http://www.proteinmodelportal.org/query/uniprot/P28246 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20067529 http://www.ncbi.nlm.nih.gov/pubmed/20067529 PubMed 2694948 http://www.ncbi.nlm.nih.gov/pubmed/2694948 PubMed 8486276 http://www.ncbi.nlm.nih.gov/pubmed/8486276 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416687 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416687 RefSeq WP_000213361 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000213361 STRING 511145.b2182 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2182&targetmode=cogs STRING COG0477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0477&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.2 http://www.tcdb.org/search/result.php?tc=2.A.1.2 TIGRFAMs TIGR00710 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00710 TIGRFAMs TIGR00880 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00880 UniProtKB BCR_ECOLI http://www.uniprot.org/uniprot/BCR_ECOLI UniProtKB-AC P28246 http://www.uniprot.org/uniprot/P28246 charge swissprot:BCR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BCR_ECOLI eggNOG ENOG4105C2C http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C2C eggNOG ENOG410XNNX http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNNX epestfind swissprot:BCR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BCR_ECOLI garnier swissprot:BCR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BCR_ECOLI helixturnhelix swissprot:BCR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BCR_ECOLI hmoment swissprot:BCR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BCR_ECOLI iep swissprot:BCR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BCR_ECOLI inforesidue swissprot:BCR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BCR_ECOLI octanol swissprot:BCR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BCR_ECOLI pepcoil swissprot:BCR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BCR_ECOLI pepdigest swissprot:BCR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BCR_ECOLI pepinfo swissprot:BCR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BCR_ECOLI pepnet swissprot:BCR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BCR_ECOLI pepstats swissprot:BCR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BCR_ECOLI pepwheel swissprot:BCR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BCR_ECOLI pepwindow swissprot:BCR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BCR_ECOLI sigcleave swissprot:BCR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BCR_ECOLI ## Database ID URL or Descriptions # BioGrid 4260498 201 # CATALYTIC ACTIVITY ARND_ECOLI 4-deoxy-4-formamido-beta-L-arabinose di- trans,poly-cis-undecaprenyl phosphate + H(2)O = 4-amino-4-deoxy- alpha-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + formate. {ECO 0000255|HAMAP-Rule MF_01870, ECO 0000269|PubMed 15695810}. # EcoGene EG14092 arnD # FUNCTION ARND_ECOLI Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (Probable). {ECO 0000305|PubMed 15695810}. # GO_function GO:0008418 protein-N-terminal asparagine amidohydrolase activity; IEA:UniProtKB-EC. # GO_function GO:0008759 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity; IEA:UniProtKB-EC. # GO_function GO:0018748 iprodione amidohydrolase activity; IEA:UniProtKB-EC. # GO_function GO:0018749 (3,5-dichlorophenylurea)acetate amidohydrolase activity; IEA:UniProtKB-EC. # GO_function GO:0034571 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity; IEA:UniProtKB-EC. # GO_function GO:0034573 didemethylisoproturon amidohydrolase activity; IEA:UniProtKB-EC. # GO_function GO:0034576 N-isopropylacetanilide amidohydrolase activity; IEA:UniProtKB-EC. # GO_function GO:0034781 N-cyclohexylformamide amidohydrolase activity; IEA:UniProtKB-EC. # GO_function GO:0034876 isonicotinic acid hydrazide hydrolase activity; IEA:UniProtKB-EC. # GO_function GO:0034882 cis-aconitamide amidase activity; IEA:UniProtKB-EC. # GO_function GO:0034885 gamma-N-formylaminovinylacetate hydrolase activity; IEA:UniProtKB-EC. # GO_function GO:0043747 N2-acetyl-L-lysine deacetylase activity; IEA:UniProtKB-EC. # GO_function GO:0043748 O-succinylbenzoate synthase activity; IEA:UniProtKB-EC. # GO_function GO:0043864 indoleacetamide hydrolase activity; IEA:UniProtKB-EC. # GO_function GO:0043909 N-acetylcitrulline deacetylase activity; IEA:UniProtKB-EC. # GO_function GO:0047419 N-acetylgalactosamine-6-phosphate deacetylase activity; IEA:UniProtKB-EC. # GO_function GO:0052773 diacetylchitobiose deacetylase activity; IEA:UniProtKB-EC. # GO_function GO:0052790 chitooligosaccharide deacetylase activity; IEA:UniProtKB-EC. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0009245 lipid A biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0010041 response to iron(III) ion; IGI:EcoCyc. # GO_process GO:0036108 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.20.20.370 -; 2. # HAMAP MF_01870 ArnD # INDUCTION Induced by BasR. {ECO 0000250}. # InterPro IPR002509 NODB_dom # InterPro IPR011330 Glyco_hydro/deAcase_b/a-brl # InterPro IPR023557 ArnD # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # Organism ARND_ECOLI Escherichia coli (strain K12) # PATHWAY ARND_ECOLI Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. {ECO 0000255|HAMAP-Rule MF_01870, ECO 0000269|PubMed 17928292}. # PATHWAY ARND_ECOLI Glycolipid biosynthesis; 4-amino-4-deoxy-alpha-L- arabinose undecaprenyl phosphate biosynthesis; 4-amino-4-deoxy- alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4- formamido-beta-L-arabinose and undecaprenyl phosphate step 2/2. {ECO 0000255|HAMAP-Rule MF_01870, ECO 0000269|PubMed 17928292}. # PATRIC 32119877 VBIEscCol129921_2348 # PIR F64996 F64996 # PROSITE PS51677 NODB # Pfam PF01522 Polysacc_deac_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD {ECO:0000255|HAMAP-Rule MF_01870} # RefSeq NP_416759 NC_000913.3 # RefSeq WP_000169728 NZ_LN832404.1 # SIMILARITY Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily. {ECO:0000255|HAMAP-Rule MF_01870}. # SIMILARITY Contains 1 NodB homology domain. {ECO:0000255|HAMAP- Rule MF_01870}. # SUPFAM SSF88713 SSF88713; 2 # UniPathway UPA00036 UER00496 # eggNOG COG0726 LUCA # eggNOG ENOG4105F73 Bacteria BLAST swissprot:ARND_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARND_ECOLI BioCyc ECOL316407:JW2250-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2250-MONOMER BioCyc EcoCyc:G7169-MONOMER http://biocyc.org/getid?id=EcoCyc:G7169-MONOMER COG COG0726 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0726 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M414265200 http://dx.doi.org/10.1074/jbc.M414265200 DOI 10.1074/jbc.M706172200 http://dx.doi.org/10.1074/jbc.M706172200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.5.1.n3 {ECO:0000255|HAMAP-Rule:MF_01870} http://www.genome.jp/dbget-bin/www_bget?EC:3.5.1.n3 {ECO:0000255|HAMAP-Rule:MF_01870} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.5.1.n3 {ECO:0000255|HAMAP-Rule:MF_01870} http://enzyme.expasy.org/EC/3.5.1.n3 {ECO:0000255|HAMAP-Rule:MF_01870} EchoBASE EB3845 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3845 EcoGene EG14092 http://www.ecogene.org/geneInfo.php?eg_id=EG14092 EnsemblBacteria AAC75316 http://www.ensemblgenomes.org/id/AAC75316 EnsemblBacteria AAC75316 http://www.ensemblgenomes.org/id/AAC75316 EnsemblBacteria BAE76673 http://www.ensemblgenomes.org/id/BAE76673 EnsemblBacteria BAE76673 http://www.ensemblgenomes.org/id/BAE76673 EnsemblBacteria BAE76673 http://www.ensemblgenomes.org/id/BAE76673 EnsemblBacteria b2256 http://www.ensemblgenomes.org/id/b2256 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008418 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008418 GO_function GO:0008759 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008759 GO_function GO:0018748 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018748 GO_function GO:0018749 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018749 GO_function GO:0034571 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034571 GO_function GO:0034573 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034573 GO_function GO:0034576 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034576 GO_function GO:0034781 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034781 GO_function GO:0034876 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034876 GO_function GO:0034882 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034882 GO_function GO:0034885 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034885 GO_function GO:0043747 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043747 GO_function GO:0043748 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043748 GO_function GO:0043864 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043864 GO_function GO:0043909 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043909 GO_function GO:0047419 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047419 GO_function GO:0052773 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052773 GO_function GO:0052790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052790 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GO_process GO:0009245 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009245 GO_process GO:0010041 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010041 GO_process GO:0036108 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036108 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.20.20.370 http://www.cathdb.info/version/latest/superfamily/3.20.20.370 GeneID 945334 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945334 HAMAP MF_01870 http://hamap.expasy.org/unirule/MF_01870 HOGENOM HOG000261199 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261199&db=HOGENOM6 InParanoid P76472 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76472 IntAct P76472 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76472* IntEnz 3.5.1.n3 {ECO:0000255|HAMAP-Rule:MF_01870} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.1.n3 {ECO:0000255|HAMAP-Rule:MF_01870} InterPro IPR002509 http://www.ebi.ac.uk/interpro/entry/IPR002509 InterPro IPR011330 http://www.ebi.ac.uk/interpro/entry/IPR011330 InterPro IPR023557 http://www.ebi.ac.uk/interpro/entry/IPR023557 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Gene ecj:JW2250 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2250 KEGG_Gene eco:b2256 http://www.genome.jp/dbget-bin/www_bget?eco:b2256 KEGG_Orthology KO:K13014 http://www.genome.jp/dbget-bin/www_bget?KO:K13014 OMA KFLWKML http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KFLWKML PROSITE PS51677 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51677 PSORT swissprot:ARND_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARND_ECOLI PSORT-B swissprot:ARND_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARND_ECOLI PSORT2 swissprot:ARND_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARND_ECOLI Pfam PF01522 http://pfam.xfam.org/family/PF01522 Phobius swissprot:ARND_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARND_ECOLI PhylomeDB P76472 http://phylomedb.org/?seqid=P76472 ProteinModelPortal P76472 http://www.proteinmodelportal.org/query/uniprot/P76472 PubMed 15695810 http://www.ncbi.nlm.nih.gov/pubmed/15695810 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17928292 http://www.ncbi.nlm.nih.gov/pubmed/17928292 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416759 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416759 RefSeq WP_000169728 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000169728 STRING 511145.b2256 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2256&targetmode=cogs STRING COG0726 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0726&targetmode=cogs SUPFAM SSF88713 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF88713 UniProtKB ARND_ECOLI http://www.uniprot.org/uniprot/ARND_ECOLI UniProtKB-AC P76472 http://www.uniprot.org/uniprot/P76472 charge swissprot:ARND_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARND_ECOLI eggNOG COG0726 http://eggnogapi.embl.de/nog_data/html/tree/COG0726 eggNOG ENOG4105F73 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F73 epestfind swissprot:ARND_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARND_ECOLI garnier swissprot:ARND_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARND_ECOLI helixturnhelix swissprot:ARND_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARND_ECOLI hmoment swissprot:ARND_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARND_ECOLI iep swissprot:ARND_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARND_ECOLI inforesidue swissprot:ARND_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARND_ECOLI octanol swissprot:ARND_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARND_ECOLI pepcoil swissprot:ARND_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARND_ECOLI pepdigest swissprot:ARND_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARND_ECOLI pepinfo swissprot:ARND_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARND_ECOLI pepnet swissprot:ARND_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARND_ECOLI pepstats swissprot:ARND_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARND_ECOLI pepwheel swissprot:ARND_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARND_ECOLI pepwindow swissprot:ARND_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARND_ECOLI sigcleave swissprot:ARND_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARND_ECOLI ## Database ID URL or Descriptions # BioGrid 4259879 2 # EcoGene EG10708 pheP # FUNCTION PHEP_ECOLI Permease that is involved in the transport across the cytoplasmic membrane of phenylalanine. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0015179 L-amino acid transmembrane transporter activity; IBA:GO_Central. # GO_function GO:0015297 antiporter activity; IBA:GO_Central. # GO_process GO:0015823 phenylalanine transport; IGI:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR002293 AA/rel_permease1 # InterPro IPR004840 Amoino_acid_permease_CS # InterPro IPR004841 AA-permease/SLC12A_dom # KEGG_Brite ko02000 Transporters # Organism PHEP_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11785 PTHR11785 # PATRIC 32116320 VBIEscCol129921_0600 # PIR A39431 A39431 # PIRSF PIRSF006060 AA_transporter # PROSITE PS00218 AMINO_ACID_PERMEASE_1 # Pfam PF00324 AA_permease # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PHEP_ECOLI Phenylalanine-specific permease # RefSeq NP_415108 NC_000913.3 # RefSeq WP_000786319 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40774.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family. {ECO 0000305}. # SUBCELLULAR LOCATION PHEP_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.3.1 the amino acid-polyamine-organocation (apc) family # eggNOG COG1113 LUCA # eggNOG ENOG4105C85 Bacteria BLAST swissprot:PHEP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PHEP_ECOLI BioCyc ECOL316407:JW0565-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0565-MONOMER BioCyc EcoCyc:PHEP-MONOMER http://biocyc.org/getid?id=EcoCyc:PHEP-MONOMER BioCyc MetaCyc:PHEP-MONOMER http://biocyc.org/getid?id=MetaCyc:PHEP-MONOMER COG COG1113 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1113 DIP DIP-10479N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10479N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M58000 http://www.ebi.ac.uk/ena/data/view/M58000 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB0702 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0702 EcoGene EG10708 http://www.ecogene.org/geneInfo.php?eg_id=EG10708 EnsemblBacteria AAC73677 http://www.ensemblgenomes.org/id/AAC73677 EnsemblBacteria AAC73677 http://www.ensemblgenomes.org/id/AAC73677 EnsemblBacteria BAA35216 http://www.ensemblgenomes.org/id/BAA35216 EnsemblBacteria BAA35216 http://www.ensemblgenomes.org/id/BAA35216 EnsemblBacteria BAA35216 http://www.ensemblgenomes.org/id/BAA35216 EnsemblBacteria b0576 http://www.ensemblgenomes.org/id/b0576 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015179 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015179 GO_function GO:0015297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015297 GO_process GO:0015823 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015823 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 945199 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945199 HOGENOM HOG000261849 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261849&db=HOGENOM6 InParanoid P24207 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P24207 IntAct P24207 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P24207* InterPro IPR002293 http://www.ebi.ac.uk/interpro/entry/IPR002293 InterPro IPR004840 http://www.ebi.ac.uk/interpro/entry/IPR004840 InterPro IPR004841 http://www.ebi.ac.uk/interpro/entry/IPR004841 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0565 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0565 KEGG_Gene eco:b0576 http://www.genome.jp/dbget-bin/www_bget?eco:b0576 KEGG_Orthology KO:K11732 http://www.genome.jp/dbget-bin/www_bget?KO:K11732 OMA VIMIISP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VIMIISP PANTHER PTHR11785 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11785 PROSITE PS00218 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00218 PSORT swissprot:PHEP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PHEP_ECOLI PSORT-B swissprot:PHEP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PHEP_ECOLI PSORT2 swissprot:PHEP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PHEP_ECOLI Pfam PF00324 http://pfam.xfam.org/family/PF00324 Phobius swissprot:PHEP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PHEP_ECOLI PhylomeDB P24207 http://phylomedb.org/?seqid=P24207 ProteinModelPortal P24207 http://www.proteinmodelportal.org/query/uniprot/P24207 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1711024 http://www.ncbi.nlm.nih.gov/pubmed/1711024 PubMed 8626334 http://www.ncbi.nlm.nih.gov/pubmed/8626334 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415108 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415108 RefSeq WP_000786319 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000786319 STRING 511145.b0576 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0576&targetmode=cogs STRING COG1113 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1113&targetmode=cogs TCDB 2.A.3.1 http://www.tcdb.org/search/result.php?tc=2.A.3.1 UniProtKB PHEP_ECOLI http://www.uniprot.org/uniprot/PHEP_ECOLI UniProtKB-AC P24207 http://www.uniprot.org/uniprot/P24207 charge swissprot:PHEP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PHEP_ECOLI eggNOG COG1113 http://eggnogapi.embl.de/nog_data/html/tree/COG1113 eggNOG ENOG4105C85 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C85 epestfind swissprot:PHEP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PHEP_ECOLI garnier swissprot:PHEP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PHEP_ECOLI helixturnhelix swissprot:PHEP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PHEP_ECOLI hmoment swissprot:PHEP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PHEP_ECOLI iep swissprot:PHEP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PHEP_ECOLI inforesidue swissprot:PHEP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PHEP_ECOLI octanol swissprot:PHEP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PHEP_ECOLI pepcoil swissprot:PHEP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PHEP_ECOLI pepdigest swissprot:PHEP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PHEP_ECOLI pepinfo swissprot:PHEP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PHEP_ECOLI pepnet swissprot:PHEP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PHEP_ECOLI pepstats swissprot:PHEP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PHEP_ECOLI pepwheel swissprot:PHEP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PHEP_ECOLI pepwindow swissprot:PHEP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PHEP_ECOLI sigcleave swissprot:PHEP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PHEP_ECOLI ## Database ID URL or Descriptions # AltName PTXC_ECOLI PTS system EIIC component # BioGrid 4260807 9 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # DOMAIN PTXC_ECOLI The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site. # EcoGene EG11710 glvC # FUNCTION PTXC_ECOLI The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. {ECO 0000250}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0008982 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:InterPro. # GO_process GO:0008643 carbohydrate transport; TAS:EcoliWiki. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR003352 PTS_EIIC # InterPro IPR004719 PTS_maltose/Glc_sub_IIC # InterPro IPR010975 PTS_IIBC_a_glc # InterPro IPR013013 PTS_EIIC_1 # Organism PTXC_ECOLI Escherichia coli (strain K12) # PATRIC 48666694 VBIEscCol107702_3617 # PIR D65170 D65170 # PROSITE PS51103 PTS_EIIC_TYPE_1 # Pfam PF02378 PTS_EIIC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PTXC_ECOLI Putative permease IIC component GlvC # RefSeq WP_000952140 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA62035.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Contains 1 PTS EIIC type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00426}. # SUBCELLULAR LOCATION PTXC_ECOLI Cell inner membrane; Multi-pass membrane protein. Note=When overexpressed. # TIGRFAMs TIGR00852 pts-Glc # TIGRFAMs TIGR02005 PTS-IIBC-alpha # eggNOG COG1263 LUCA BLAST swissprot:PTXC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTXC_ECOLI BioCyc ECOL316407:JW3660-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3660-MONOMER BioCyc EcoCyc:GLVC-MONOMER http://biocyc.org/getid?id=EcoCyc:GLVC-MONOMER DOI 10.1002/pro.5560030309 http://dx.doi.org/10.1002/pro.5560030309 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1661 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1661 EcoGene EG11710 http://www.ecogene.org/geneInfo.php?eg_id=EG11710 EnsemblBacteria BAE77611 http://www.ensemblgenomes.org/id/BAE77611 EnsemblBacteria BAE77611 http://www.ensemblgenomes.org/id/BAE77611 EnsemblBacteria BAE77611 http://www.ensemblgenomes.org/id/BAE77611 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008982 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008982 GO_process GO:0008643 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008643 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 HOGENOM HOG000250994 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000250994&db=HOGENOM6 InParanoid P31452 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31452 InterPro IPR003352 http://www.ebi.ac.uk/interpro/entry/IPR003352 InterPro IPR004719 http://www.ebi.ac.uk/interpro/entry/IPR004719 InterPro IPR010975 http://www.ebi.ac.uk/interpro/entry/IPR010975 InterPro IPR013013 http://www.ebi.ac.uk/interpro/entry/IPR013013 KEGG_Gene ecj:JW3660 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3660 OMA KQNARAS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KQNARAS PROSITE PS51103 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51103 PSORT swissprot:PTXC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTXC_ECOLI PSORT-B swissprot:PTXC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTXC_ECOLI PSORT2 swissprot:PTXC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTXC_ECOLI Pfam PF02378 http://pfam.xfam.org/family/PF02378 Phobius swissprot:PTXC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTXC_ECOLI PhylomeDB P31452 http://phylomedb.org/?seqid=P31452 ProteinModelPortal P31452 http://www.proteinmodelportal.org/query/uniprot/P31452 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 8019415 http://www.ncbi.nlm.nih.gov/pubmed/8019415 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000952140 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000952140 STRING 316407.85676361 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85676361&targetmode=cogs TIGRFAMs TIGR00852 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00852 TIGRFAMs TIGR02005 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02005 UniProtKB PTXC_ECOLI http://www.uniprot.org/uniprot/PTXC_ECOLI UniProtKB-AC P31452 http://www.uniprot.org/uniprot/P31452 charge swissprot:PTXC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTXC_ECOLI eggNOG COG1263 http://eggnogapi.embl.de/nog_data/html/tree/COG1263 epestfind swissprot:PTXC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTXC_ECOLI garnier swissprot:PTXC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTXC_ECOLI helixturnhelix swissprot:PTXC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTXC_ECOLI hmoment swissprot:PTXC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTXC_ECOLI iep swissprot:PTXC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTXC_ECOLI inforesidue swissprot:PTXC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTXC_ECOLI octanol swissprot:PTXC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTXC_ECOLI pepcoil swissprot:PTXC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTXC_ECOLI pepdigest swissprot:PTXC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTXC_ECOLI pepinfo swissprot:PTXC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTXC_ECOLI pepnet swissprot:PTXC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTXC_ECOLI pepstats swissprot:PTXC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTXC_ECOLI pepwheel swissprot:PTXC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTXC_ECOLI pepwindow swissprot:PTXC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTXC_ECOLI sigcleave swissprot:PTXC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTXC_ECOLI ## Database ID URL or Descriptions # BioGrid 4261610 243 # CAZy GT73 Glycosyltransferase Family 73 # EcoGene EG11426 rfaZ # GO_process GO:0009244 lipopolysaccharide core region biosynthetic process; IMP:EcoCyc. # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # IntAct P27241 7 # InterPro IPR031026 WaaZ_KDO_III # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01003 Glycosyltransferases # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # Organism RFAZ_ECOLI Escherichia coli (strain K12) # PATHWAY RFAZ_ECOLI Bacterial outer membrane biogenesis; LPS core biosynthesis. # PATRIC 32122735 VBIEscCol129921_3744 # PIR S47845 S47845 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RFAZ_ECOLI Lipopolysaccharide core biosynthesis protein RfaZ # RefSeq NP_418081 NC_000913.3 # RefSeq WP_000790279 NZ_LN832404.1 # TIGRFAMs TIGR04437 WaaZ_KDO_III # eggNOG ENOG4108QD8 Bacteria # eggNOG ENOG410XR3T LUCA BLAST swissprot:RFAZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RFAZ_ECOLI BioCyc ECOL316407:JW3599-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3599-MONOMER BioCyc EcoCyc:EG11426-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11426-MONOMER BioCyc MetaCyc:EG11426-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11426-MONOMER COG CAZy: http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=CAZy: COG GT73 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=GT73 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M95398 http://www.ebi.ac.uk/ena/data/view/M95398 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1396 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1396 EcoGene EG11426 http://www.ecogene.org/geneInfo.php?eg_id=EG11426 EnsemblBacteria AAC76648 http://www.ensemblgenomes.org/id/AAC76648 EnsemblBacteria AAC76648 http://www.ensemblgenomes.org/id/AAC76648 EnsemblBacteria BAE77668 http://www.ensemblgenomes.org/id/BAE77668 EnsemblBacteria BAE77668 http://www.ensemblgenomes.org/id/BAE77668 EnsemblBacteria BAE77668 http://www.ensemblgenomes.org/id/BAE77668 EnsemblBacteria b3624 http://www.ensemblgenomes.org/id/b3624 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0009244 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009244 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 948146 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948146 HOGENOM HOG000028345 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000028345&db=HOGENOM6 IntAct P27241 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P27241* InterPro IPR031026 http://www.ebi.ac.uk/interpro/entry/IPR031026 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01003 http://www.genome.jp/dbget-bin/www_bget?ko01003 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Gene ecj:JW3599 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3599 KEGG_Gene eco:b3624 http://www.genome.jp/dbget-bin/www_bget?eco:b3624 KEGG_Orthology KO:K12981 http://www.genome.jp/dbget-bin/www_bget?KO:K12981 OMA LSHNIVP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LSHNIVP PSORT swissprot:RFAZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RFAZ_ECOLI PSORT-B swissprot:RFAZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RFAZ_ECOLI PSORT2 swissprot:RFAZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RFAZ_ECOLI Phobius swissprot:RFAZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RFAZ_ECOLI ProteinModelPortal P27241 http://www.proteinmodelportal.org/query/uniprot/P27241 PubMed 1624462 http://www.ncbi.nlm.nih.gov/pubmed/1624462 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418081 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418081 RefSeq WP_000790279 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000790279 STRING 511145.b3624 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3624&targetmode=cogs STRING CAZy: http://string-db.org/newstring_cgi/show_network_section.pl?identifier=CAZy:&targetmode=cogs STRING GT73 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=GT73&targetmode=cogs TIGRFAMs TIGR04437 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR04437 UniProtKB RFAZ_ECOLI http://www.uniprot.org/uniprot/RFAZ_ECOLI UniProtKB-AC P27241 http://www.uniprot.org/uniprot/P27241 charge swissprot:RFAZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RFAZ_ECOLI eggNOG ENOG4108QD8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108QD8 eggNOG ENOG410XR3T http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XR3T epestfind swissprot:RFAZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RFAZ_ECOLI garnier swissprot:RFAZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RFAZ_ECOLI helixturnhelix swissprot:RFAZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RFAZ_ECOLI hmoment swissprot:RFAZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RFAZ_ECOLI iep swissprot:RFAZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RFAZ_ECOLI inforesidue swissprot:RFAZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RFAZ_ECOLI octanol swissprot:RFAZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RFAZ_ECOLI pepcoil swissprot:RFAZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RFAZ_ECOLI pepdigest swissprot:RFAZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RFAZ_ECOLI pepinfo swissprot:RFAZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RFAZ_ECOLI pepnet swissprot:RFAZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RFAZ_ECOLI pepstats swissprot:RFAZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RFAZ_ECOLI pepwheel swissprot:RFAZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RFAZ_ECOLI pepwindow swissprot:RFAZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RFAZ_ECOLI sigcleave swissprot:RFAZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RFAZ_ECOLI ## Database ID URL or Descriptions # BioGrid 4261730 284 # EcoGene EG12874 yajI # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GOslim_component GO:0005886 plasma membrane # Gene3D 2.60.40.1620 -; 1. # InterPro IPR021658 DUF3251 # Organism YAJI_ECOLI Escherichia coli (strain K12) # PATRIC 32115973 VBIEscCol129921_0428 # PDB 2JWY NMR; -; A=21-179 # PIR D64770 D64770 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF11622 DUF3251 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAJI_ECOLI Uncharacterized lipoprotein YajI # RefSeq NP_414946 NC_000913.3 # RefSeq WP_001326929 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA74983.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAB40168.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SUBCELLULAR LOCATION YAJI_ECOLI Cell membrane {ECO 0000305}; Lipid-anchor {ECO 0000305}. # eggNOG ENOG4108KIC Bacteria # eggNOG ENOG410XTE8 LUCA BLAST swissprot:YAJI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAJI_ECOLI BioCyc ECOL316407:JW5056-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5056-MONOMER BioCyc EcoCyc:EG12874-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12874-MONOMER DOI 10.1007/BF00538702 http://dx.doi.org/10.1007/BF00538702 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U31810 http://www.ebi.ac.uk/ena/data/view/U31810 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL X64395 http://www.ebi.ac.uk/ena/data/view/X64395 EchoBASE EB2712 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2712 EcoGene EG12874 http://www.ecogene.org/geneInfo.php?eg_id=EG12874 EnsemblBacteria AAC73515 http://www.ensemblgenomes.org/id/AAC73515 EnsemblBacteria AAC73515 http://www.ensemblgenomes.org/id/AAC73515 EnsemblBacteria BAE76192 http://www.ensemblgenomes.org/id/BAE76192 EnsemblBacteria BAE76192 http://www.ensemblgenomes.org/id/BAE76192 EnsemblBacteria BAE76192 http://www.ensemblgenomes.org/id/BAE76192 EnsemblBacteria b0412 http://www.ensemblgenomes.org/id/b0412 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 Gene3D 2.60.40.1620 http://www.cathdb.info/version/latest/superfamily/2.60.40.1620 GeneID 947233 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947233 HOGENOM HOG000117555 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117555&db=HOGENOM6 InterPro IPR021658 http://www.ebi.ac.uk/interpro/entry/IPR021658 KEGG_Gene ecj:JW5056 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5056 KEGG_Gene eco:b0412 http://www.genome.jp/dbget-bin/www_bget?eco:b0412 OMA QEVNVQN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QEVNVQN PDB 2JWY http://www.ebi.ac.uk/pdbe-srv/view/entry/2JWY PDBsum 2JWY http://www.ebi.ac.uk/pdbsum/2JWY PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YAJI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAJI_ECOLI PSORT-B swissprot:YAJI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAJI_ECOLI PSORT2 swissprot:YAJI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAJI_ECOLI Pfam PF11622 http://pfam.xfam.org/family/PF11622 Phobius swissprot:YAJI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAJI_ECOLI ProteinModelPortal P46122 http://www.proteinmodelportal.org/query/uniprot/P46122 PubMed 1406588 http://www.ncbi.nlm.nih.gov/pubmed/1406588 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414946 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414946 RefSeq WP_001326929 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001326929 SMR P46122 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P46122 STRING 511145.b0412 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0412&targetmode=cogs UniProtKB YAJI_ECOLI http://www.uniprot.org/uniprot/YAJI_ECOLI UniProtKB-AC P46122 http://www.uniprot.org/uniprot/P46122 charge swissprot:YAJI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAJI_ECOLI eggNOG ENOG4108KIC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108KIC eggNOG ENOG410XTE8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XTE8 epestfind swissprot:YAJI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAJI_ECOLI garnier swissprot:YAJI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAJI_ECOLI helixturnhelix swissprot:YAJI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAJI_ECOLI hmoment swissprot:YAJI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAJI_ECOLI iep swissprot:YAJI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAJI_ECOLI inforesidue swissprot:YAJI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAJI_ECOLI octanol swissprot:YAJI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAJI_ECOLI pepcoil swissprot:YAJI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAJI_ECOLI pepdigest swissprot:YAJI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAJI_ECOLI pepinfo swissprot:YAJI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAJI_ECOLI pepnet swissprot:YAJI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAJI_ECOLI pepstats swissprot:YAJI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAJI_ECOLI pepwheel swissprot:YAJI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAJI_ECOLI pepwindow swissprot:YAJI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAJI_ECOLI sigcleave swissprot:YAJI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAJI_ECOLI ## Database ID URL or Descriptions # BioGrid 4261657 298 # COFACTOR ERPA_ECOLI Name=iron-sulfur cluster; Xref=ChEBI CHEBI 30408; Evidence={ECO 0000269|PubMed 17698959}; Note=Binds 1 iron-sulfur cluster per subunit. A study found 40-50% as [2Fe-2S] clusters, 15-25% as [4Fe-4S] clusters and the rest as paramagnetic iron. {ECO 0000269|PubMed 17698959}; # DISRUPTION PHENOTYPE Reduced amounts of quinones. {ECO:0000269|PubMed 17698959}. # EcoGene EG12332 erpA # FUNCTION ERPA_ECOLI Probably involved in the insertion of Fe-S clusters into apoproteins in vivo including IspG and/or IspH. Essential for growth under aerobic conditions and for anaerobic respiration but not for fermentation. In vitro it binds Fe-S clusters and transfers them to apo-IspG, which is involved in quinone biosynthesis among many other cell components. Experiments indicate that it is probably also involved in the insertion of other Fe-S clusters than IspG/IspH. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0005198 structural molecule activity; IEA:InterPro. # GO_function GO:0005506 iron ion binding; IBA:GO_Central. # GO_function GO:0008198 ferrous iron binding; IBA:GO_Central. # GO_function GO:0051537 2 iron, 2 sulfur cluster binding; IDA:EcoCyc. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IDA:EcoCyc. # GO_process GO:0006790 sulfur compound metabolic process; IBA:GO_Central. # GO_process GO:0009060 aerobic respiration; IMP:EcoCyc. # GO_process GO:0009061 anaerobic respiration; IMP:EcoCyc. # GO_process GO:0016226 iron-sulfur cluster assembly; IDA:EcoCyc. # GO_process GO:0051604 protein maturation; IDA:EcoCyc. # GO_process GO:0097428 protein maturation by iron-sulfur cluster transfer; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0005198 structural molecule activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0051186 cofactor metabolic process # GOslim_process GO:0051604 protein maturation # Gene3D 2.60.300.12 -; 1. # HAMAP MF_01380 Fe_S_insert_ErpA # IntAct P0ACC3 8 # InterPro IPR000361 FeS_biogenesis # InterPro IPR016092 FeS_cluster_insertion # InterPro IPR017870 FeS_cluster_insertion_CS # InterPro IPR023063 FeS_cluster_insertion_RrpA # Organism ERPA_ECOLI Escherichia coli (strain K12) # PATRIC 32115421 VBIEscCol129921_0162 # PIR S45225 S45225 # PROSITE PS01152 HESB # Pfam PF01521 Fe-S_biosyn # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ERPA_ECOLI Iron-sulfur cluster insertion protein ErpA # RefSeq NP_414698 NC_000913.3 # RefSeq WP_001295564 NZ_LN832404.1 # SIMILARITY Belongs to the HesB/IscA family. {ECO 0000305}. # SUBUNIT Homodimer. {ECO 0000305}. # SUPFAM SSF89360 SSF89360 # TIGRFAMs TIGR00049 TIGR00049 # eggNOG COG0316 LUCA # eggNOG ENOG4108YX9 Bacteria BLAST swissprot:ERPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ERPA_ECOLI BioCyc ECOL316407:JW0152-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0152-MONOMER BioCyc EcoCyc:EG12332-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12332-MONOMER COG COG0316 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0316 DIP DIP-48196N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48196N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0705829104 http://dx.doi.org/10.1073/pnas.0705829104 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EchoBASE EB2236 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2236 EcoGene EG12332 http://www.ecogene.org/geneInfo.php?eg_id=EG12332 EnsemblBacteria AAC73267 http://www.ensemblgenomes.org/id/AAC73267 EnsemblBacteria AAC73267 http://www.ensemblgenomes.org/id/AAC73267 EnsemblBacteria BAB96733 http://www.ensemblgenomes.org/id/BAB96733 EnsemblBacteria BAB96733 http://www.ensemblgenomes.org/id/BAB96733 EnsemblBacteria BAB96733 http://www.ensemblgenomes.org/id/BAB96733 EnsemblBacteria b0156 http://www.ensemblgenomes.org/id/b0156 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0005198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005198 GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0008198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008198 GO_function GO:0051537 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051537 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GO_process GO:0009060 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009060 GO_process GO:0009061 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009061 GO_process GO:0016226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016226 GO_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 GO_process GO:0097428 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097428 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0005198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005198 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GOslim_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 Gene3D 2.60.300.12 http://www.cathdb.info/version/latest/superfamily/2.60.300.12 GeneID 944857 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944857 HAMAP MF_01380 http://hamap.expasy.org/unirule/MF_01380 HOGENOM HOG000228313 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000228313&db=HOGENOM6 InParanoid P0ACC3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACC3 IntAct P0ACC3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACC3* InterPro IPR000361 http://www.ebi.ac.uk/interpro/entry/IPR000361 InterPro IPR016092 http://www.ebi.ac.uk/interpro/entry/IPR016092 InterPro IPR017870 http://www.ebi.ac.uk/interpro/entry/IPR017870 InterPro IPR023063 http://www.ebi.ac.uk/interpro/entry/IPR023063 KEGG_Gene ecj:JW0152 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0152 KEGG_Gene eco:b0156 http://www.genome.jp/dbget-bin/www_bget?eco:b0156 KEGG_Orthology KO:K15724 http://www.genome.jp/dbget-bin/www_bget?KO:K15724 OMA FQYKFDV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FQYKFDV PROSITE PS01152 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01152 PSORT swissprot:ERPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ERPA_ECOLI PSORT-B swissprot:ERPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ERPA_ECOLI PSORT2 swissprot:ERPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ERPA_ECOLI Pfam PF01521 http://pfam.xfam.org/family/PF01521 Phobius swissprot:ERPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ERPA_ECOLI PhylomeDB P0ACC3 http://phylomedb.org/?seqid=P0ACC3 ProteinModelPortal P0ACC3 http://www.proteinmodelportal.org/query/uniprot/P0ACC3 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17698959 http://www.ncbi.nlm.nih.gov/pubmed/17698959 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414698 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414698 RefSeq WP_001295564 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295564 STRING 511145.b0156 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0156&targetmode=cogs STRING COG0316 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0316&targetmode=cogs SUPFAM SSF89360 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF89360 TIGRFAMs TIGR00049 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00049 UniProtKB ERPA_ECOLI http://www.uniprot.org/uniprot/ERPA_ECOLI UniProtKB-AC P0ACC3 http://www.uniprot.org/uniprot/P0ACC3 charge swissprot:ERPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ERPA_ECOLI eggNOG COG0316 http://eggnogapi.embl.de/nog_data/html/tree/COG0316 eggNOG ENOG4108YX9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108YX9 epestfind swissprot:ERPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ERPA_ECOLI garnier swissprot:ERPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ERPA_ECOLI helixturnhelix swissprot:ERPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ERPA_ECOLI hmoment swissprot:ERPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ERPA_ECOLI iep swissprot:ERPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ERPA_ECOLI inforesidue swissprot:ERPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ERPA_ECOLI octanol swissprot:ERPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ERPA_ECOLI pepcoil swissprot:ERPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ERPA_ECOLI pepdigest swissprot:ERPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ERPA_ECOLI pepinfo swissprot:ERPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ERPA_ECOLI pepnet swissprot:ERPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ERPA_ECOLI pepstats swissprot:ERPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ERPA_ECOLI pepwheel swissprot:ERPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ERPA_ECOLI pepwindow swissprot:ERPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ERPA_ECOLI sigcleave swissprot:ERPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ERPA_ECOLI ## Database ID URL or Descriptions # AltName Protein C5 {ECO:0000255|HAMAP-Rule MF_00227} # BioGrid 4261766 14 # CATALYTIC ACTIVITY RNPA_ECOLI Endonucleolytic cleavage of RNA, removing 5'- extranucleotides from tRNA precursor. {ECO 0000255|HAMAP- Rule MF_00227, ECO 0000269|PubMed 22298511}. # EcoGene EG10862 rnpA # FUNCTION RNPA_ECOLI RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. {ECO 0000255|HAMAP-Rule MF_00227, ECO 0000269|PubMed 22298511}. # GO_function GO:0000049 tRNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0004526 ribonuclease P activity; IDA:EcoCyc. # GO_process GO:0001682 tRNA 5'-leader removal; IDA:EcoliWiki. # GO_process GO:0006396 RNA processing; IDA:EcoliWiki. # GO_process GO:0008033 tRNA processing; IMP:EcoCyc. # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0004518 nuclease activity # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.30.230.10 -; 1. # HAMAP MF_00227 RNase_P # IntAct P0A7Y8 56 # InterPro IPR000100 RNase_P # InterPro IPR014721 Ribosomal_S5_D2-typ_fold_subgr # InterPro IPR020539 RNase_P_CS # InterPro IPR020568 Ribosomal_S5_D2-typ_fold # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # Organism RNPA_ECOLI Escherichia coli (strain K12) # PATRIC 32122905 VBIEscCol129921_3828 # PDB 2LJP NMR; -; A=1-119 # PIR A00794 NRECP # PROSITE PS00648 RIBONUCLEASE_P # Pfam PF00825 Ribonuclease_P # ProDom PD003629 Ribonuclease_P # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Ribonuclease P protein component {ECO:0000255|HAMAP-Rule MF_00227} # RefSeq NP_418159 NC_000913.3 # RefSeq WP_000239730 NZ_LN832404.1 # SIMILARITY Belongs to the RnpA family. {ECO:0000255|HAMAP- Rule MF_00227}. # SUBUNIT RNPA_ECOLI Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit. {ECO 0000255|HAMAP-Rule MF_00227, ECO 0000269|PubMed 22298511}. # SUPFAM SSF54211 SSF54211 # TIGRFAMs TIGR00188 rnpA # eggNOG COG0594 LUCA # eggNOG ENOG4105NVJ Bacteria BLAST swissprot:RNPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RNPA_ECOLI BioCyc ECOL316407:JW3681-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3681-MONOMER BioCyc EcoCyc:EG10862-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10862-MONOMER BioCyc MetaCyc:EG10862-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10862-MONOMER COG COG0594 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0594 DIP DIP-36039N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36039N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1016/0378-1119(85)90206-9 http://dx.doi.org/10.1016/0378-1119(85)90206-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gks013 http://dx.doi.org/10.1093/nar/gks013 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.26.5 {ECO:0000255|HAMAP-Rule:MF_00227} http://www.genome.jp/dbget-bin/www_bget?EC:3.1.26.5 {ECO:0000255|HAMAP-Rule:MF_00227} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M11056 http://www.ebi.ac.uk/ena/data/view/M11056 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X01861 http://www.ebi.ac.uk/ena/data/view/X01861 ENZYME 3.1.26.5 {ECO:0000255|HAMAP-Rule:MF_00227} http://enzyme.expasy.org/EC/3.1.26.5 {ECO:0000255|HAMAP-Rule:MF_00227} EchoBASE EB0855 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0855 EcoGene EG10862 http://www.ecogene.org/geneInfo.php?eg_id=EG10862 EnsemblBacteria AAC76727 http://www.ensemblgenomes.org/id/AAC76727 EnsemblBacteria AAC76727 http://www.ensemblgenomes.org/id/AAC76727 EnsemblBacteria BAE77590 http://www.ensemblgenomes.org/id/BAE77590 EnsemblBacteria BAE77590 http://www.ensemblgenomes.org/id/BAE77590 EnsemblBacteria BAE77590 http://www.ensemblgenomes.org/id/BAE77590 EnsemblBacteria b3704 http://www.ensemblgenomes.org/id/b3704 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000049 GO_function GO:0004526 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004526 GO_process GO:0001682 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001682 GO_process GO:0006396 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006396 GO_process GO:0008033 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008033 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.30.230.10 http://www.cathdb.info/version/latest/superfamily/3.30.230.10 GeneID 948215 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948215 HAMAP MF_00227 http://hamap.expasy.org/unirule/MF_00227 HOGENOM HOG000266301 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000266301&db=HOGENOM6 InParanoid P0A7Y8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7Y8 IntAct P0A7Y8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7Y8* IntEnz 3.1.26.5 {ECO:0000255|HAMAP-Rule:MF_00227} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.26.5 {ECO:0000255|HAMAP-Rule:MF_00227} InterPro IPR000100 http://www.ebi.ac.uk/interpro/entry/IPR000100 InterPro IPR014721 http://www.ebi.ac.uk/interpro/entry/IPR014721 InterPro IPR020539 http://www.ebi.ac.uk/interpro/entry/IPR020539 InterPro IPR020568 http://www.ebi.ac.uk/interpro/entry/IPR020568 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW3681 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3681 KEGG_Gene eco:b3704 http://www.genome.jp/dbget-bin/www_bget?eco:b3704 KEGG_Orthology KO:K03536 http://www.genome.jp/dbget-bin/www_bget?KO:K03536 MINT MINT-1218365 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1218365 OMA PPMDFVV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PPMDFVV PDB 2LJP http://www.ebi.ac.uk/pdbe-srv/view/entry/2LJP PDBsum 2LJP http://www.ebi.ac.uk/pdbsum/2LJP PROSITE PS00648 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00648 PSORT swissprot:RNPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RNPA_ECOLI PSORT-B swissprot:RNPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RNPA_ECOLI PSORT2 swissprot:RNPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RNPA_ECOLI Pfam PF00825 http://pfam.xfam.org/family/PF00825 Phobius swissprot:RNPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RNPA_ECOLI PhylomeDB P0A7Y8 http://phylomedb.org/?seqid=P0A7Y8 ProteinModelPortal P0A7Y8 http://www.proteinmodelportal.org/query/uniprot/P0A7Y8 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22298511 http://www.ncbi.nlm.nih.gov/pubmed/22298511 PubMed 2415431 http://www.ncbi.nlm.nih.gov/pubmed/2415431 PubMed 6329723 http://www.ncbi.nlm.nih.gov/pubmed/6329723 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418159 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418159 RefSeq WP_000239730 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000239730 SMR P0A7Y8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7Y8 STRING 511145.b3704 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3704&targetmode=cogs STRING COG0594 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0594&targetmode=cogs SUPFAM SSF54211 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54211 TIGRFAMs TIGR00188 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00188 UniProtKB RNPA_ECOLI http://www.uniprot.org/uniprot/RNPA_ECOLI UniProtKB-AC P0A7Y8 http://www.uniprot.org/uniprot/P0A7Y8 charge swissprot:RNPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RNPA_ECOLI eggNOG COG0594 http://eggnogapi.embl.de/nog_data/html/tree/COG0594 eggNOG ENOG4105NVJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105NVJ epestfind swissprot:RNPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RNPA_ECOLI garnier swissprot:RNPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RNPA_ECOLI helixturnhelix swissprot:RNPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RNPA_ECOLI hmoment swissprot:RNPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RNPA_ECOLI iep swissprot:RNPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RNPA_ECOLI inforesidue swissprot:RNPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RNPA_ECOLI octanol swissprot:RNPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RNPA_ECOLI pepcoil swissprot:RNPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RNPA_ECOLI pepdigest swissprot:RNPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RNPA_ECOLI pepinfo swissprot:RNPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RNPA_ECOLI pepnet swissprot:RNPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RNPA_ECOLI pepstats swissprot:RNPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RNPA_ECOLI pepwheel swissprot:RNPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RNPA_ECOLI pepwindow swissprot:RNPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RNPA_ECOLI sigcleave swissprot:RNPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RNPA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260560 22 # EcoGene EG14149 ypdB # FUNCTION YPDB_ECOLI Member of the two-component regulatory system YpdA/YpdB involved in carbon control network. Regulates expression of yhjX by binding to its promoter region. {ECO 0000269|PubMed 23222720}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_process GO:0000160 phosphorelay signal transduction system; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # InterPro IPR001789 Sig_transdc_resp-reg_receiver # InterPro IPR007492 LytTR_DNA-bd_dom # InterPro IPR011006 CheY-like_superfamily # KEGG_Brite ko02022 Two-component system # Organism YPDB_ECOLI Escherichia coli (strain K12) # PATRIC 32120141 VBIEscCol129921_2479 # PIR B65012 B65012 # PROSITE PS50110 RESPONSE_REGULATORY # PROSITE PS50930 HTH_LYTTR # PTM YPDB_ECOLI Phosphorylated by YpdA. {ECO 0000250}. # Pfam PF00072 Response_reg # Pfam PF04397 LytTR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YPDB_ECOLI Transcriptional regulatory protein YpdB # RefSeq NP_416882 NC_000913.3 # RefSeq WP_001295458 NZ_LN832404.1 # SIMILARITY Contains 1 HTH LytTR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00112}. # SIMILARITY Contains 1 response regulatory domain. {ECO:0000255|PROSITE-ProRule PRU00169}. # SMART SM00448 REC # SMART SM00850 LytTR # SUBCELLULAR LOCATION YPDB_ECOLI Cytoplasm {ECO 0000250}. # SUPFAM SSF52172 SSF52172 # eggNOG COG3279 LUCA # eggNOG ENOG4105DY9 Bacteria BLAST swissprot:YPDB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YPDB_ECOLI BioCyc ECOL316407:JW2378-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2378-MONOMER BioCyc EcoCyc:G7244-MONOMER http://biocyc.org/getid?id=EcoCyc:G7244-MONOMER COG COG3279 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3279 DIP DIP-48228N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48228N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.02051-12 http://dx.doi.org/10.1128/JB.02051-12 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3901 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3901 EcoGene EG14149 http://www.ecogene.org/geneInfo.php?eg_id=EG14149 EnsemblBacteria AAC75440 http://www.ensemblgenomes.org/id/AAC75440 EnsemblBacteria AAC75440 http://www.ensemblgenomes.org/id/AAC75440 EnsemblBacteria BAA16251 http://www.ensemblgenomes.org/id/BAA16251 EnsemblBacteria BAA16251 http://www.ensemblgenomes.org/id/BAA16251 EnsemblBacteria BAA16251 http://www.ensemblgenomes.org/id/BAA16251 EnsemblBacteria b2381 http://www.ensemblgenomes.org/id/b2381 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 947395 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947395 HOGENOM HOG000242207 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000242207&db=HOGENOM6 InParanoid P0AE39 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AE39 IntAct P0AE39 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AE39* InterPro IPR001789 http://www.ebi.ac.uk/interpro/entry/IPR001789 InterPro IPR007492 http://www.ebi.ac.uk/interpro/entry/IPR007492 InterPro IPR011006 http://www.ebi.ac.uk/interpro/entry/IPR011006 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW2378 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2378 KEGG_Gene eco:b2381 http://www.genome.jp/dbget-bin/www_bget?eco:b2381 KEGG_Orthology KO:K02477 http://www.genome.jp/dbget-bin/www_bget?KO:K02477 OMA SYLIRVP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SYLIRVP PROSITE PS50110 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50110 PROSITE PS50930 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50930 PSORT swissprot:YPDB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YPDB_ECOLI PSORT-B swissprot:YPDB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YPDB_ECOLI PSORT2 swissprot:YPDB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YPDB_ECOLI Pfam PF00072 http://pfam.xfam.org/family/PF00072 Pfam PF04397 http://pfam.xfam.org/family/PF04397 Phobius swissprot:YPDB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YPDB_ECOLI PhylomeDB P0AE39 http://phylomedb.org/?seqid=P0AE39 ProteinModelPortal P0AE39 http://www.proteinmodelportal.org/query/uniprot/P0AE39 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 23222720 http://www.ncbi.nlm.nih.gov/pubmed/23222720 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416882 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416882 RefSeq WP_001295458 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295458 SMART SM00448 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00448 SMART SM00850 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00850 STRING 511145.b2381 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2381&targetmode=cogs STRING COG3279 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3279&targetmode=cogs SUPFAM SSF52172 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52172 UniProtKB YPDB_ECOLI http://www.uniprot.org/uniprot/YPDB_ECOLI UniProtKB-AC P0AE39 http://www.uniprot.org/uniprot/P0AE39 charge swissprot:YPDB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YPDB_ECOLI eggNOG COG3279 http://eggnogapi.embl.de/nog_data/html/tree/COG3279 eggNOG ENOG4105DY9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DY9 epestfind swissprot:YPDB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YPDB_ECOLI garnier swissprot:YPDB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YPDB_ECOLI helixturnhelix swissprot:YPDB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YPDB_ECOLI hmoment swissprot:YPDB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YPDB_ECOLI iep swissprot:YPDB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YPDB_ECOLI inforesidue swissprot:YPDB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YPDB_ECOLI octanol swissprot:YPDB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YPDB_ECOLI pepcoil swissprot:YPDB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YPDB_ECOLI pepdigest swissprot:YPDB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YPDB_ECOLI pepinfo swissprot:YPDB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YPDB_ECOLI pepnet swissprot:YPDB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YPDB_ECOLI pepstats swissprot:YPDB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YPDB_ECOLI pepwheel swissprot:YPDB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YPDB_ECOLI pepwindow swissprot:YPDB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YPDB_ECOLI sigcleave swissprot:YPDB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YPDB_ECOLI ## Database ID URL or Descriptions # AltName ALLA_ECOLI Ureidoglycolate hydrolase # AltName Ureidoglycolatase {ECO:0000255|HAMAP-Rule MF_00616} # BioGrid 4259861 14 # CATALYTIC ACTIVITY ALLA_ECOLI (S)-ureidoglycolate = glyoxylate + urea. {ECO 0000255|HAMAP-Rule MF_00616, ECO 0000269|PubMed 24107613}. # COFACTOR ALLA_ECOLI Name=Ni(2+); Xref=ChEBI CHEBI 49786; Evidence={ECO 0000255|HAMAP-Rule MF_00616, ECO 0000269|PubMed 24107613}; # EcoGene EG13615 allA # FUNCTION ALLA_ECOLI Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the anaerobic utilization of allantoin as sole nitrogen source. Reinforces the induction of genes involved in the degradation of allantoin and glyoxylate by producing glyoxylate. {ECO 0000255|HAMAP-Rule MF_00616, ECO 0000269|PubMed 10601204, ECO 0000269|PubMed 24107613}. # GO_function GO:0004848 ureidoglycolate hydrolase activity; IEA:InterPro. # GO_function GO:0050385 ureidoglycolate lyase activity; IDA:EcoCyc. # GO_process GO:0000256 allantoin catabolic process; IEA:UniProtKB-HAMAP. # GO_process GO:0006145 purine nucleobase catabolic process; IEA:UniProtKB-HAMAP. # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 2.60.120.480 -; 1. # HAMAP MF_00616 Ureidogly_lyase # INDUCTION ALLA_ECOLI By glyoxylate and allantoin under anaerobic conditions and by glyoxylate under aerobic conditions. # IntAct P77731 4 # InterPro IPR007247 Ureidogly_lyase # InterPro IPR011051 RmlC_Cupin # InterPro IPR023525 Ureidogly_lyase_bac # InterPro IPR024060 Ureidoglycolate_lyase_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # Organism ALLA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21221 PTHR21221 # PATHWAY Nitrogen metabolism; (S)-allantoin degradation. {ECO:0000255|HAMAP-Rule MF_00616}. # PATRIC 32116169 VBIEscCol129921_0526 # PDB 1XSQ X-ray; 1.60 A; A/B=1-160 # PIR H64781 H64781 # PIRSF PIRSF017306 Ureidogly_hydro # Pfam PF04115 Ureidogly_lyase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Ureidoglycolate lyase {ECO:0000255|HAMAP-Rule MF_00616} # RefSeq NP_415038 NC_000913.3 # RefSeq WP_000776377 NZ_LN832404.1 # SIMILARITY Belongs to the ureidoglycolate lyase family. {ECO:0000255|HAMAP-Rule MF_00616}. # SUBUNIT Homodimer. {ECO:0000255|HAMAP-Rule MF_00616, ECO:0000269|Ref.6}. # SUPFAM SSF51182 SSF51182 # eggNOG COG3194 LUCA # eggNOG ENOG4108Z2U Bacteria BLAST swissprot:ALLA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ALLA_ECOLI BioCyc ECOL316407:JW0493-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0493-MONOMER BioCyc EcoCyc:G6275-MONOMER http://biocyc.org/getid?id=EcoCyc:G6275-MONOMER BioCyc MetaCyc:G6275-MONOMER http://biocyc.org/getid?id=MetaCyc:G6275-MONOMER COG COG3194 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3194 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/database/bat071 http://dx.doi.org/10.1093/database/bat071 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.3.2.3 {ECO:0000255|HAMAP-Rule:MF_00616} http://www.genome.jp/dbget-bin/www_bget?EC:4.3.2.3 {ECO:0000255|HAMAP-Rule:MF_00616} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL U89024 http://www.ebi.ac.uk/ena/data/view/U89024 ENZYME 4.3.2.3 {ECO:0000255|HAMAP-Rule:MF_00616} http://enzyme.expasy.org/EC/4.3.2.3 {ECO:0000255|HAMAP-Rule:MF_00616} EchoBASE EB3381 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3381 EcoGene EG13615 http://www.ecogene.org/geneInfo.php?eg_id=EG13615 EnsemblBacteria AAC73607 http://www.ensemblgenomes.org/id/AAC73607 EnsemblBacteria AAC73607 http://www.ensemblgenomes.org/id/AAC73607 EnsemblBacteria BAE76283 http://www.ensemblgenomes.org/id/BAE76283 EnsemblBacteria BAE76283 http://www.ensemblgenomes.org/id/BAE76283 EnsemblBacteria BAE76283 http://www.ensemblgenomes.org/id/BAE76283 EnsemblBacteria b0505 http://www.ensemblgenomes.org/id/b0505 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004848 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004848 GO_function GO:0050385 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050385 GO_process GO:0000256 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000256 GO_process GO:0006145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006145 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 2.60.120.480 http://www.cathdb.info/version/latest/superfamily/2.60.120.480 GeneID 945141 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945141 HAMAP MF_00616 http://hamap.expasy.org/unirule/MF_00616 HOGENOM HOG000256169 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000256169&db=HOGENOM6 InParanoid P77731 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77731 IntAct P77731 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77731* IntEnz 4.3.2.3 {ECO:0000255|HAMAP-Rule:MF_00616} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.3.2.3 {ECO:0000255|HAMAP-Rule:MF_00616} InterPro IPR007247 http://www.ebi.ac.uk/interpro/entry/IPR007247 InterPro IPR011051 http://www.ebi.ac.uk/interpro/entry/IPR011051 InterPro IPR023525 http://www.ebi.ac.uk/interpro/entry/IPR023525 InterPro IPR024060 http://www.ebi.ac.uk/interpro/entry/IPR024060 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0493 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0493 KEGG_Gene eco:b0505 http://www.genome.jp/dbget-bin/www_bget?eco:b0505 KEGG_Orthology KO:K01483 http://www.genome.jp/dbget-bin/www_bget?KO:K01483 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Reaction rn:R00469 http://www.genome.jp/dbget-bin/www_bget?rn:R00469 OMA EMMERHP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EMMERHP PANTHER PTHR21221 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21221 PDB 1XSQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1XSQ PDBsum 1XSQ http://www.ebi.ac.uk/pdbsum/1XSQ PSORT swissprot:ALLA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ALLA_ECOLI PSORT-B swissprot:ALLA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ALLA_ECOLI PSORT2 swissprot:ALLA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ALLA_ECOLI Pfam PF04115 http://pfam.xfam.org/family/PF04115 Phobius swissprot:ALLA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ALLA_ECOLI PhylomeDB P77731 http://phylomedb.org/?seqid=P77731 ProteinModelPortal P77731 http://www.proteinmodelportal.org/query/uniprot/P77731 PubMed 10601204 http://www.ncbi.nlm.nih.gov/pubmed/10601204 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 24107613 http://www.ncbi.nlm.nih.gov/pubmed/24107613 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415038 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415038 RefSeq WP_000776377 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000776377 SMR P77731 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77731 STRING 511145.b0505 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0505&targetmode=cogs STRING COG3194 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3194&targetmode=cogs SUPFAM SSF51182 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51182 UniProtKB ALLA_ECOLI http://www.uniprot.org/uniprot/ALLA_ECOLI UniProtKB-AC P77731 http://www.uniprot.org/uniprot/P77731 charge swissprot:ALLA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ALLA_ECOLI eggNOG COG3194 http://eggnogapi.embl.de/nog_data/html/tree/COG3194 eggNOG ENOG4108Z2U http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Z2U epestfind swissprot:ALLA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ALLA_ECOLI garnier swissprot:ALLA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ALLA_ECOLI helixturnhelix swissprot:ALLA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ALLA_ECOLI hmoment swissprot:ALLA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ALLA_ECOLI iep swissprot:ALLA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ALLA_ECOLI inforesidue swissprot:ALLA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ALLA_ECOLI octanol swissprot:ALLA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ALLA_ECOLI pepcoil swissprot:ALLA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ALLA_ECOLI pepdigest swissprot:ALLA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ALLA_ECOLI pepinfo swissprot:ALLA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ALLA_ECOLI pepnet swissprot:ALLA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ALLA_ECOLI pepstats swissprot:ALLA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ALLA_ECOLI pepwheel swissprot:ALLA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ALLA_ECOLI pepwindow swissprot:ALLA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ALLA_ECOLI sigcleave swissprot:ALLA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ALLA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262728 224 # EcoGene EG12536 lptG # FUNCTION LPTG_ECOLI Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. {ECO 0000269|PubMed 18375759}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IDA:EcoCyc. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IDA:EcoCyc. # GO_process GO:0015920 lipopolysaccharide transport; IMP:EcoCyc. # GO_process GO:0055085 transmembrane transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # InterPro IPR005495 LptG/LptF_permease # InterPro IPR030923 LptG # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00320 Lipopolysaccharide export system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism LPTG_ECOLI Escherichia coli (strain K12) # PATRIC 32124097 VBIEscCol129921_4393 # Pfam PF03739 YjgP_YjgQ # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LPTG_ECOLI Lipopolysaccharide export system permease protein LptG # RefSeq NP_418683 NC_000913.3 # RefSeq WP_001295681 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97159.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the LptF/LptG family. {ECO 0000305}. # SUBCELLULAR LOCATION LPTG_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT Component of the lipopolysaccharide transport and assembly complex. The LptBFG transporter is composed of two ATP- binding proteins (LptB) and two transmembrane proteins (LptF and LptG). {ECO:0000269|PubMed 19500581}. # TCDB 1.B.42.1 the outer membrane lipopolysaccharide export porin (lps-ep) family # TIGRFAMs TIGR04408 LptG_lptG # eggNOG COG0795 LUCA # eggNOG ENOG4108K5H Bacteria BLAST swissprot:LPTG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LPTG_ECOLI BioCyc ECOL316407:JW5760-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5760-MONOMER BioCyc EcoCyc:G7889-MONOMER http://biocyc.org/getid?id=EcoCyc:G7889-MONOMER BioCyc MetaCyc:G7889-MONOMER http://biocyc.org/getid?id=MetaCyc:G7889-MONOMER COG COG0795 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0795 DOI 10.1016/j.febslet.2009.05.051 http://dx.doi.org/10.1016/j.febslet.2009.05.051 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0801196105 http://dx.doi.org/10.1073/pnas.0801196105 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2425 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2425 EcoGene EG12536 http://www.ecogene.org/geneInfo.php?eg_id=EG12536 EnsemblBacteria AAC77219 http://www.ensemblgenomes.org/id/AAC77219 EnsemblBacteria AAC77219 http://www.ensemblgenomes.org/id/AAC77219 EnsemblBacteria BAE78259 http://www.ensemblgenomes.org/id/BAE78259 EnsemblBacteria BAE78259 http://www.ensemblgenomes.org/id/BAE78259 EnsemblBacteria BAE78259 http://www.ensemblgenomes.org/id/BAE78259 EnsemblBacteria b4262 http://www.ensemblgenomes.org/id/b4262 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_process GO:0015920 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015920 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 945324 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945324 HOGENOM HOG000263593 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000263593&db=HOGENOM6 InParanoid P0ADC6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADC6 IntAct P0ADC6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADC6* InterPro IPR005495 http://www.ebi.ac.uk/interpro/entry/IPR005495 InterPro IPR030923 http://www.ebi.ac.uk/interpro/entry/IPR030923 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5760 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5760 KEGG_Gene eco:b4262 http://www.genome.jp/dbget-bin/www_bget?eco:b4262 KEGG_Orthology KO:K11720 http://www.genome.jp/dbget-bin/www_bget?KO:K11720 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 MINT MINT-7137015 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-7137015 OMA FAYLHAR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FAYLHAR PSORT swissprot:LPTG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LPTG_ECOLI PSORT-B swissprot:LPTG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LPTG_ECOLI PSORT2 swissprot:LPTG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LPTG_ECOLI Pfam PF03739 http://pfam.xfam.org/family/PF03739 Phobius swissprot:LPTG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LPTG_ECOLI PhylomeDB P0ADC6 http://phylomedb.org/?seqid=P0ADC6 ProteinModelPortal P0ADC6 http://www.proteinmodelportal.org/query/uniprot/P0ADC6 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18375759 http://www.ncbi.nlm.nih.gov/pubmed/18375759 PubMed 19500581 http://www.ncbi.nlm.nih.gov/pubmed/19500581 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418683 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418683 RefSeq WP_001295681 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295681 STRING 511145.b4262 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4262&targetmode=cogs STRING COG0795 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0795&targetmode=cogs TCDB 1.B.42.1 http://www.tcdb.org/search/result.php?tc=1.B.42.1 TIGRFAMs TIGR04408 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR04408 UniProtKB LPTG_ECOLI http://www.uniprot.org/uniprot/LPTG_ECOLI UniProtKB-AC P0ADC6 http://www.uniprot.org/uniprot/P0ADC6 charge swissprot:LPTG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LPTG_ECOLI eggNOG COG0795 http://eggnogapi.embl.de/nog_data/html/tree/COG0795 eggNOG ENOG4108K5H http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108K5H epestfind swissprot:LPTG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LPTG_ECOLI garnier swissprot:LPTG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LPTG_ECOLI helixturnhelix swissprot:LPTG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LPTG_ECOLI hmoment swissprot:LPTG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LPTG_ECOLI iep swissprot:LPTG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LPTG_ECOLI inforesidue swissprot:LPTG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LPTG_ECOLI octanol swissprot:LPTG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LPTG_ECOLI pepcoil swissprot:LPTG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LPTG_ECOLI pepdigest swissprot:LPTG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LPTG_ECOLI pepinfo swissprot:LPTG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LPTG_ECOLI pepnet swissprot:LPTG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LPTG_ECOLI pepstats swissprot:LPTG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LPTG_ECOLI pepwheel swissprot:LPTG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LPTG_ECOLI pepwindow swissprot:LPTG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LPTG_ECOLI sigcleave swissprot:LPTG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LPTG_ECOLI ## Database ID URL or Descriptions # BioGrid 4259143 11 # CDD cd06660 Aldo_ket_red # EcoGene EG13483 ydjG # GO_function GO:0004033 aldo-keto reductase (NADP) activity; IDA:EcoCyc. # GOslim_function GO:0016491 oxidoreductase activity # Gene3D 3.20.20.100 -; 1. # IntAct P77256 3 # InterPro IPR001395 Aldo/ket_red/Kv-b # InterPro IPR020471 Aldo/keto_reductase # InterPro IPR023210 NADP_OxRdtase_dom # Organism YDJG_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11732 PTHR11732 # PATRIC 32118853 VBIEscCol129921_1844 # PIR C64937 C64937 # PRINTS PR00069 ALDKETRDTASE # Pfam PF00248 Aldo_ket_red # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDJG_ECOLI Uncharacterized oxidoreductase YdjG # RefSeq NP_416285 NC_000913.3 # RefSeq WP_000723710 NZ_LN832404.1 # SIMILARITY Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily. {ECO 0000305}. # SUPFAM SSF51430 SSF51430 # eggNOG COG0667 LUCA # eggNOG ENOG4105CPC Bacteria BLAST swissprot:YDJG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDJG_ECOLI BioCyc ECOL316407:JW1760-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1760-MONOMER BioCyc EcoCyc:G6958-MONOMER http://biocyc.org/getid?id=EcoCyc:G6958-MONOMER BioCyc MetaCyc:G6958-MONOMER http://biocyc.org/getid?id=MetaCyc:G6958-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- EchoBASE EB3256 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3256 EcoGene EG13483 http://www.ecogene.org/geneInfo.php?eg_id=EG13483 EnsemblBacteria AAC74841 http://www.ensemblgenomes.org/id/AAC74841 EnsemblBacteria AAC74841 http://www.ensemblgenomes.org/id/AAC74841 EnsemblBacteria BAA15562 http://www.ensemblgenomes.org/id/BAA15562 EnsemblBacteria BAA15562 http://www.ensemblgenomes.org/id/BAA15562 EnsemblBacteria BAA15562 http://www.ensemblgenomes.org/id/BAA15562 EnsemblBacteria b1771 http://www.ensemblgenomes.org/id/b1771 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004033 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004033 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 Gene3D 3.20.20.100 http://www.cathdb.info/version/latest/superfamily/3.20.20.100 GeneID 946283 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946283 HOGENOM HOG000250284 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000250284&db=HOGENOM6 InParanoid P77256 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77256 IntAct P77256 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77256* IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR001395 http://www.ebi.ac.uk/interpro/entry/IPR001395 InterPro IPR020471 http://www.ebi.ac.uk/interpro/entry/IPR020471 InterPro IPR023210 http://www.ebi.ac.uk/interpro/entry/IPR023210 KEGG_Gene ecj:JW1760 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1760 KEGG_Gene eco:b1771 http://www.genome.jp/dbget-bin/www_bget?eco:b1771 OMA ARDIECE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ARDIECE PANTHER PTHR11732 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11732 PRINTS PR00069 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00069 PSORT swissprot:YDJG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDJG_ECOLI PSORT-B swissprot:YDJG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDJG_ECOLI PSORT2 swissprot:YDJG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDJG_ECOLI Pfam PF00248 http://pfam.xfam.org/family/PF00248 Phobius swissprot:YDJG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDJG_ECOLI PhylomeDB P77256 http://phylomedb.org/?seqid=P77256 ProteinModelPortal P77256 http://www.proteinmodelportal.org/query/uniprot/P77256 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416285 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416285 RefSeq WP_000723710 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000723710 SMR P77256 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77256 STRING 511145.b1771 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1771&targetmode=cogs SUPFAM SSF51430 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51430 UniProtKB YDJG_ECOLI http://www.uniprot.org/uniprot/YDJG_ECOLI UniProtKB-AC P77256 http://www.uniprot.org/uniprot/P77256 charge swissprot:YDJG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDJG_ECOLI eggNOG COG0667 http://eggnogapi.embl.de/nog_data/html/tree/COG0667 eggNOG ENOG4105CPC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CPC epestfind swissprot:YDJG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDJG_ECOLI garnier swissprot:YDJG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDJG_ECOLI helixturnhelix swissprot:YDJG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDJG_ECOLI hmoment swissprot:YDJG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDJG_ECOLI iep swissprot:YDJG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDJG_ECOLI inforesidue swissprot:YDJG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDJG_ECOLI octanol swissprot:YDJG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDJG_ECOLI pepcoil swissprot:YDJG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDJG_ECOLI pepdigest swissprot:YDJG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDJG_ECOLI pepinfo swissprot:YDJG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDJG_ECOLI pepnet swissprot:YDJG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDJG_ECOLI pepstats swissprot:YDJG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDJG_ECOLI pepwheel swissprot:YDJG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDJG_ECOLI pepwindow swissprot:YDJG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDJG_ECOLI sigcleave swissprot:YDJG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDJG_ECOLI ## Database ID URL or Descriptions # AltName COBT_ECOLI N(1)-alpha-phosphoribosyltransferase # BioGrid 4262028 15 # CATALYTIC ACTIVITY COBT_ECOLI Beta-nicotinate D-ribonucleotide + 5,6- dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate. # CDD cd02439 DMB-PRT_CobT # EcoGene EG12151 cobT # FUNCTION COBT_ECOLI Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB). # GO_function GO:0008939 nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0015420 cobalamin-transporting ATPase activity; IEA:UniProtKB-HAMAP. # GO_process GO:0009163 nucleoside biosynthetic process; IEA:InterPro. # GO_process GO:0009236 cobalamin biosynthetic process; IMP:EcoliWiki. # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.1610.10 -; 1. # HAMAP MF_00230 CobT # IntAct P36562 5 # InterPro IPR003200 Nict_dMeBzImd_PRibTrfase-like # InterPro IPR017846 Nict_dMeBzImd_PRibTrfase_pro # InterPro IPR023195 Nict_dMeBzImd_PRibTrfase_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00860 Porphyrin and chlorophyll metabolism # Organism COBT_ECOLI Escherichia coli (strain K12) # PATHWAY Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole step 1/2. # PATRIC 32119313 VBIEscCol129921_2066 # PIR F64963 F64963 # Pfam PF02277 DBI_PRT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName COBT_ECOLI Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase # RefSeq NP_416495 NC_000913.3 # RefSeq WP_001166160 NZ_LN832404.1 # SIMILARITY Belongs to the CobT family. {ECO 0000305}. # SUBUNIT Homodimer. {ECO 0000250}. # SUPFAM SSF52733 SSF52733 # TIGRFAMs TIGR03160 cobT_DBIPRT # UniPathway UPA00061 UER00516 # eggNOG COG2038 LUCA # eggNOG ENOG4105CUP Bacteria BLAST swissprot:COBT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:COBT_ECOLI BioCyc ECOL316407:JW1969-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1969-MONOMER BioCyc EcoCyc:DMBPPRIBOSYLTRANS-MONOMER http://biocyc.org/getid?id=EcoCyc:DMBPPRIBOSYLTRANS-MONOMER COG COG2038 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2038 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.4.2.21 http://www.genome.jp/dbget-bin/www_bget?EC:2.4.2.21 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L25054 http://www.ebi.ac.uk/ena/data/view/L25054 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U33333 http://www.ebi.ac.uk/ena/data/view/U33333 ENZYME 2.4.2.21 http://enzyme.expasy.org/EC/2.4.2.21 EchoBASE EB2071 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2071 EcoGene EG12151 http://www.ecogene.org/geneInfo.php?eg_id=EG12151 EnsemblBacteria AAC75052 http://www.ensemblgenomes.org/id/AAC75052 EnsemblBacteria AAC75052 http://www.ensemblgenomes.org/id/AAC75052 EnsemblBacteria BAA15808 http://www.ensemblgenomes.org/id/BAA15808 EnsemblBacteria BAA15808 http://www.ensemblgenomes.org/id/BAA15808 EnsemblBacteria BAA15808 http://www.ensemblgenomes.org/id/BAA15808 EnsemblBacteria b1991 http://www.ensemblgenomes.org/id/b1991 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008939 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008939 GO_function GO:0015420 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015420 GO_process GO:0009163 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009163 GO_process GO:0009236 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009236 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.1610.10 http://www.cathdb.info/version/latest/superfamily/1.10.1610.10 GeneID 946517 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946517 HAMAP MF_00230 http://hamap.expasy.org/unirule/MF_00230 HOGENOM HOG000263499 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000263499&db=HOGENOM6 InParanoid P36562 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P36562 IntAct P36562 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P36562* IntEnz 2.4.2.21 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.2.21 InterPro IPR003200 http://www.ebi.ac.uk/interpro/entry/IPR003200 InterPro IPR017846 http://www.ebi.ac.uk/interpro/entry/IPR017846 InterPro IPR023195 http://www.ebi.ac.uk/interpro/entry/IPR023195 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1969 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1969 KEGG_Gene eco:b1991 http://www.genome.jp/dbget-bin/www_bget?eco:b1991 KEGG_Orthology KO:K00768 http://www.genome.jp/dbget-bin/www_bget?KO:K00768 KEGG_Pathway ko00860 http://www.genome.jp/kegg-bin/show_pathway?ko00860 KEGG_Reaction rn:R04148 http://www.genome.jp/dbget-bin/www_bget?rn:R04148 OMA MNNMATF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MNNMATF PSORT swissprot:COBT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:COBT_ECOLI PSORT-B swissprot:COBT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:COBT_ECOLI PSORT2 swissprot:COBT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:COBT_ECOLI Pfam PF02277 http://pfam.xfam.org/family/PF02277 Phobius swissprot:COBT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:COBT_ECOLI PhylomeDB P36562 http://phylomedb.org/?seqid=P36562 ProteinModelPortal P36562 http://www.proteinmodelportal.org/query/uniprot/P36562 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7592411 http://www.ncbi.nlm.nih.gov/pubmed/7592411 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416495 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416495 RefSeq WP_001166160 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001166160 SMR P36562 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P36562 STRING 511145.b1991 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1991&targetmode=cogs STRING COG2038 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2038&targetmode=cogs SUPFAM SSF52733 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52733 TIGRFAMs TIGR03160 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03160 UniProtKB COBT_ECOLI http://www.uniprot.org/uniprot/COBT_ECOLI UniProtKB-AC P36562 http://www.uniprot.org/uniprot/P36562 charge swissprot:COBT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:COBT_ECOLI eggNOG COG2038 http://eggnogapi.embl.de/nog_data/html/tree/COG2038 eggNOG ENOG4105CUP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CUP epestfind swissprot:COBT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:COBT_ECOLI garnier swissprot:COBT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:COBT_ECOLI helixturnhelix swissprot:COBT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:COBT_ECOLI hmoment swissprot:COBT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:COBT_ECOLI iep swissprot:COBT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:COBT_ECOLI inforesidue swissprot:COBT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:COBT_ECOLI octanol swissprot:COBT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:COBT_ECOLI pepcoil swissprot:COBT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:COBT_ECOLI pepdigest swissprot:COBT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:COBT_ECOLI pepinfo swissprot:COBT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:COBT_ECOLI pepnet swissprot:COBT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:COBT_ECOLI pepstats swissprot:COBT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:COBT_ECOLI pepwheel swissprot:COBT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:COBT_ECOLI pepwindow swissprot:COBT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:COBT_ECOLI sigcleave swissprot:COBT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:COBT_ECOLI ## Database ID URL or Descriptions # AltName YDDB_ECOLI CDS103 # BioGrid 4260786 154 # EcoGene EG11743 yddB # GO_component GO:0016020 membrane; IEA:InterPro. # GO_function GO:0004872 receptor activity; IEA:InterPro. # GO_process GO:0006810 transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006810 transport # Gene3D 2.170.130.10 -; 1. # Gene3D 2.40.170.20 -; 2. # InterPro IPR000531 TonB-dep_rcpt_b-brl # InterPro IPR012910 Plug_dom # Organism YDDB_ECOLI Escherichia coli (strain K12) # PATRIC 32118284 VBIEscCol129921_1562 # PIR B64903 B64903 # Pfam PF00593 TonB_dep_Rec # Pfam PF07715 Plug # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDDB_ECOLI Uncharacterized protein YddB # RefSeq NP_416012 NC_000913.3 # RefSeq WP_000832437 NZ_LN832404.1 # SIMILARITY To H.influenzae HI_1369. {ECO 0000305}. # eggNOG ENOG4105PE1 Bacteria # eggNOG ENOG410XSVA LUCA BLAST swissprot:YDDB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDDB_ECOLI BioCyc ECOL316407:JW1490-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1490-MONOMER BioCyc EcoCyc:EG11743-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11743-MONOMER DIP DIP-11661N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11661N DOI 10.1016/S0300-9084(97)84334-9 http://dx.doi.org/10.1016/S0300-9084(97)84334-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X71917 http://www.ebi.ac.uk/ena/data/view/X71917 EchoBASE EB1694 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1694 EcoGene EG11743 http://www.ecogene.org/geneInfo.php?eg_id=EG11743 EnsemblBacteria AAC74568 http://www.ensemblgenomes.org/id/AAC74568 EnsemblBacteria AAC74568 http://www.ensemblgenomes.org/id/AAC74568 EnsemblBacteria BAA15166 http://www.ensemblgenomes.org/id/BAA15166 EnsemblBacteria BAA15166 http://www.ensemblgenomes.org/id/BAA15166 EnsemblBacteria BAA15166 http://www.ensemblgenomes.org/id/BAA15166 EnsemblBacteria b1495 http://www.ensemblgenomes.org/id/b1495 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0004872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004872 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 2.170.130.10 http://www.cathdb.info/version/latest/superfamily/2.170.130.10 Gene3D 2.40.170.20 http://www.cathdb.info/version/latest/superfamily/2.40.170.20 GeneID 945961 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945961 HOGENOM HOG000120697 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120697&db=HOGENOM6 IntAct P31827 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31827* InterPro IPR000531 http://www.ebi.ac.uk/interpro/entry/IPR000531 InterPro IPR012910 http://www.ebi.ac.uk/interpro/entry/IPR012910 KEGG_Gene ecj:JW1490 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1490 KEGG_Gene eco:b1495 http://www.genome.jp/dbget-bin/www_bget?eco:b1495 OMA NRYYGRS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NRYYGRS PSORT swissprot:YDDB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDDB_ECOLI PSORT-B swissprot:YDDB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDDB_ECOLI PSORT2 swissprot:YDDB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDDB_ECOLI Pfam PF00593 http://pfam.xfam.org/family/PF00593 Pfam PF07715 http://pfam.xfam.org/family/PF07715 Phobius swissprot:YDDB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDDB_ECOLI ProteinModelPortal P31827 http://www.proteinmodelportal.org/query/uniprot/P31827 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9116051 http://www.ncbi.nlm.nih.gov/pubmed/9116051 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416012 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416012 RefSeq WP_000832437 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000832437 STRING 511145.b1495 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1495&targetmode=cogs UniProtKB YDDB_ECOLI http://www.uniprot.org/uniprot/YDDB_ECOLI UniProtKB-AC P31827 http://www.uniprot.org/uniprot/P31827 charge swissprot:YDDB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDDB_ECOLI eggNOG ENOG4105PE1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105PE1 eggNOG ENOG410XSVA http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XSVA epestfind swissprot:YDDB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDDB_ECOLI garnier swissprot:YDDB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDDB_ECOLI helixturnhelix swissprot:YDDB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDDB_ECOLI hmoment swissprot:YDDB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDDB_ECOLI iep swissprot:YDDB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDDB_ECOLI inforesidue swissprot:YDDB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDDB_ECOLI octanol swissprot:YDDB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDDB_ECOLI pepcoil swissprot:YDDB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDDB_ECOLI pepdigest swissprot:YDDB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDDB_ECOLI pepinfo swissprot:YDDB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDDB_ECOLI pepnet swissprot:YDDB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDDB_ECOLI pepstats swissprot:YDDB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDDB_ECOLI pepwheel swissprot:YDDB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDDB_ECOLI pepwindow swissprot:YDDB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDDB_ECOLI sigcleave swissprot:YDDB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDDB_ECOLI ## Database ID URL or Descriptions # AltName MURE_ECOLI Meso-A2pm-adding enzyme # AltName MURE_ECOLI Meso-diaminopimelate-adding enzyme # AltName MURE_ECOLI UDP-MurNAc-tripeptide synthetase # AltName MURE_ECOLI UDP-N-acetylmuramyl-tripeptide synthetase # AltName UDP-MurNAc-L-Ala-D-Glu meso-diaminopimelate ligase # BIOPHYSICOCHEMICAL PROPERTIES MURE_ECOLI Kinetic parameters KM=76 uM for UDP-N-acetylmuramoyl-L-Ala-D-Glu {ECO 0000269|PubMed 2269304, ECO 0000269|PubMed 8021219}; KM=36 uM for meso-diaminopimelate {ECO 0000269|PubMed 2269304, ECO 0000269|PubMed 8021219}; KM=1500 uM for meso-lanthionine {ECO 0000269|PubMed 2269304, ECO 0000269|PubMed 8021219}; KM=3900 uM for L-allo-cystathionine {ECO 0000269|PubMed 2269304, ECO 0000269|PubMed 8021219}; KM=10000 uM for D-allo-cystathionine {ECO 0000269|PubMed 2269304, ECO 0000269|PubMed 8021219}; KM=620 uM for ATP {ECO 0000269|PubMed 2269304, ECO 0000269|PubMed 8021219}; Vmax=32 nmol/min/mg enzyme with meso-diaminopimelate as substrate {ECO 0000269|PubMed 2269304, ECO 0000269|PubMed 8021219}; Vmax=23 nmol/min/mg enzyme with meso-lanthionine as substrate {ECO 0000269|PubMed 2269304, ECO 0000269|PubMed 8021219}; Vmax=19 nmol/min/mg enzyme with L-allo-cystathionine as substrate {ECO 0000269|PubMed 2269304, ECO 0000269|PubMed 8021219}; Vmax=23 nmol/min/mg enzyme with L-allo-cystathionine as substrate {ECO 0000269|PubMed 2269304, ECO 0000269|PubMed 8021219}; pH dependence Optimum pH is about 8. {ECO 0000269|PubMed 2269304}; # BRENDA 6.3.2.13 2026 # BioGrid 4261641 527 # CATALYTIC ACTIVITY MURE_ECOLI ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl- D-glutamate + meso-2,6-diaminoheptanedioate = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6- diaminoheptanedioate. {ECO 0000269|PubMed 11124264, ECO 0000269|PubMed 2269304}. # COFACTOR MURE_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_00208}; # ENZYME REGULATION Activated by potassium phosphate. {ECO:0000269|PubMed 2269304}. # EcoGene EG10621 murE # FUNCTION MURE_ECOLI Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Is also able to use many meso-diaminopimelate analogs as substrates, although much less efficiently, but not L-lysine. {ECO 0000269|PubMed 11124264, ECO 0000269|PubMed 2269304, ECO 0000269|PubMed 3905407}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008765 UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity; IDA:EcoCyc. # GO_process GO:0007049 cell cycle; IEA:UniProtKB-KW. # GO_process GO:0008360 regulation of cell shape; IEA:UniProtKB-KW. # GO_process GO:0009252 peptidoglycan biosynthetic process; IMP:EcoCyc. # GO_process GO:0051301 cell division; IEA:UniProtKB-KW. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0007049 cell cycle # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0051301 cell division # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 3.40.1190.10 -; 1. # Gene3D 3.40.1390.10 -; 1. # Gene3D 3.90.190.20 -; 1. # HAMAP MF_00208 MurE # IntAct P22188 20 # InterPro IPR000713 Mur_ligase_N # InterPro IPR004101 Mur_ligase_C # InterPro IPR005761 UDP-N-AcMur-Glu-dNH2Pim_ligase # InterPro IPR013221 Mur_ligase_cen # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00300 Lysine biosynthesis # KEGG_Pathway ko00550 Peptidoglycan biosynthesis # Organism MURE_ECOLI Escherichia coli (strain K12) # PATHWAY MURE_ECOLI Cell wall biogenesis; peptidoglycan biosynthesis. # PATRIC 32115275 VBIEscCol129921_0089 # PDB 1E8C X-ray; 2.00 A; A/B=2-495 # PIR S14384 S14384 # PTM MURE_ECOLI Carbamoylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP. {ECO 0000269|PubMed 11124264}. # Pfam PF01225 Mur_ligase # Pfam PF02875 Mur_ligase_C # Pfam PF08245 Mur_ligase_M # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MURE_ECOLI UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase # RefSeq NP_414627 NC_000913.3 # RefSeq WP_000775093 NZ_LN832404.1 # SIMILARITY Belongs to the MurCDEF family. MurE subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION MURE_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF53244 SSF53244 # SUPFAM SSF53623 SSF53623 # SUPFAM SSF63418 SSF63418 # TIGRFAMs TIGR01085 murE # eggNOG COG0769 LUCA # eggNOG ENOG4107EEN Bacteria BLAST swissprot:MURE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MURE_ECOLI BioCyc ECOL316407:JW0083-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0083-MONOMER BioCyc EcoCyc:UDP-NACMURALGLDAPLIG-MONOMER http://biocyc.org/getid?id=EcoCyc:UDP-NACMURALGLDAPLIG-MONOMER BioCyc MetaCyc:UDP-NACMURALGLDAPLIG-MONOMER http://biocyc.org/getid?id=MetaCyc:UDP-NACMURALGLDAPLIG-MONOMER COG COG0769 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0769 DIP DIP-10280N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10280N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1021/bi9701078 http://dx.doi.org/10.1021/bi9701078 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2690277 http://dx.doi.org/10.1042/bj2690277 DOI 10.1074/jbc.M009835200 http://dx.doi.org/10.1074/jbc.M009835200 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1111/j.1432-1033.1985.tb09269.x http://dx.doi.org/10.1111/j.1432-1033.1985.tb09269.x DOI 10.1111/j.1432-1033.1990.tb19479.x http://dx.doi.org/10.1111/j.1432-1033.1990.tb19479.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.3.2.13 {ECO:0000269|PubMed:11124264, ECO:0000269|PubMed:2269304} http://www.genome.jp/dbget-bin/www_bget?EC:6.3.2.13 {ECO:0000269|PubMed:11124264, ECO:0000269|PubMed:2269304} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U67894 http://www.ebi.ac.uk/ena/data/view/U67894 EMBL X55034 http://www.ebi.ac.uk/ena/data/view/X55034 EMBL X55814 http://www.ebi.ac.uk/ena/data/view/X55814 ENZYME 6.3.2.13 {ECO:0000269|PubMed:11124264, ECO:0000269|PubMed:2269304} http://enzyme.expasy.org/EC/6.3.2.13 {ECO:0000269|PubMed:11124264, ECO:0000269|PubMed:2269304} EchoBASE EB0616 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0616 EcoGene EG10621 http://www.ecogene.org/geneInfo.php?eg_id=EG10621 EnsemblBacteria AAC73196 http://www.ensemblgenomes.org/id/AAC73196 EnsemblBacteria AAC73196 http://www.ensemblgenomes.org/id/AAC73196 EnsemblBacteria BAB96653 http://www.ensemblgenomes.org/id/BAB96653 EnsemblBacteria BAB96653 http://www.ensemblgenomes.org/id/BAB96653 EnsemblBacteria BAB96653 http://www.ensemblgenomes.org/id/BAB96653 EnsemblBacteria b0085 http://www.ensemblgenomes.org/id/b0085 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008765 GO_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0009252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009252 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 3.40.1190.10 http://www.cathdb.info/version/latest/superfamily/3.40.1190.10 Gene3D 3.40.1390.10 http://www.cathdb.info/version/latest/superfamily/3.40.1390.10 Gene3D 3.90.190.20 http://www.cathdb.info/version/latest/superfamily/3.90.190.20 GeneID 944791 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944791 HAMAP MF_00208 http://hamap.expasy.org/unirule/MF_00208 HOGENOM HOG000268118 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000268118&db=HOGENOM6 InParanoid P22188 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P22188 IntAct P22188 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P22188* IntEnz 6.3.2.13 {ECO:0000269|PubMed:11124264, ECO:0000269|PubMed:2269304} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.2.13 {ECO:0000269|PubMed:11124264, ECO:0000269|PubMed:2269304} InterPro IPR000713 http://www.ebi.ac.uk/interpro/entry/IPR000713 InterPro IPR004101 http://www.ebi.ac.uk/interpro/entry/IPR004101 InterPro IPR005761 http://www.ebi.ac.uk/interpro/entry/IPR005761 InterPro IPR013221 http://www.ebi.ac.uk/interpro/entry/IPR013221 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0083 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0083 KEGG_Gene eco:b0085 http://www.genome.jp/dbget-bin/www_bget?eco:b0085 KEGG_Orthology KO:K01928 http://www.genome.jp/dbget-bin/www_bget?KO:K01928 KEGG_Pathway ko00300 http://www.genome.jp/kegg-bin/show_pathway?ko00300 KEGG_Pathway ko00550 http://www.genome.jp/kegg-bin/show_pathway?ko00550 KEGG_Reaction rn:R02788 http://www.genome.jp/dbget-bin/www_bget?rn:R02788 MINT MINT-1230964 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1230964 OMA HNHNIKF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HNHNIKF PDB 1E8C http://www.ebi.ac.uk/pdbe-srv/view/entry/1E8C PDBsum 1E8C http://www.ebi.ac.uk/pdbsum/1E8C PSORT swissprot:MURE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MURE_ECOLI PSORT-B swissprot:MURE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MURE_ECOLI PSORT2 swissprot:MURE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MURE_ECOLI Pfam PF01225 http://pfam.xfam.org/family/PF01225 Pfam PF02875 http://pfam.xfam.org/family/PF02875 Pfam PF08245 http://pfam.xfam.org/family/PF08245 Phobius swissprot:MURE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MURE_ECOLI PhylomeDB P22188 http://phylomedb.org/?seqid=P22188 ProteinModelPortal P22188 http://www.proteinmodelportal.org/query/uniprot/P22188 PubMed 11124264 http://www.ncbi.nlm.nih.gov/pubmed/11124264 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2198024 http://www.ncbi.nlm.nih.gov/pubmed/2198024 PubMed 2269304 http://www.ncbi.nlm.nih.gov/pubmed/2269304 PubMed 2692800 http://www.ncbi.nlm.nih.gov/pubmed/2692800 PubMed 3905407 http://www.ncbi.nlm.nih.gov/pubmed/3905407 PubMed 8021219 http://www.ncbi.nlm.nih.gov/pubmed/8021219 PubMed 9166795 http://www.ncbi.nlm.nih.gov/pubmed/9166795 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_414627 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414627 RefSeq WP_000775093 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000775093 SMR P22188 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P22188 STRING 511145.b0085 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0085&targetmode=cogs STRING COG0769 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0769&targetmode=cogs SUPFAM SSF53244 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53244 SUPFAM SSF53623 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53623 SUPFAM SSF63418 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63418 SWISS-2DPAGE P22188 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P22188 TIGRFAMs TIGR01085 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01085 UniProtKB MURE_ECOLI http://www.uniprot.org/uniprot/MURE_ECOLI UniProtKB-AC P22188 http://www.uniprot.org/uniprot/P22188 charge swissprot:MURE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MURE_ECOLI eggNOG COG0769 http://eggnogapi.embl.de/nog_data/html/tree/COG0769 eggNOG ENOG4107EEN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107EEN epestfind swissprot:MURE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MURE_ECOLI garnier swissprot:MURE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MURE_ECOLI helixturnhelix swissprot:MURE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MURE_ECOLI hmoment swissprot:MURE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MURE_ECOLI iep swissprot:MURE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MURE_ECOLI inforesidue swissprot:MURE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MURE_ECOLI octanol swissprot:MURE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MURE_ECOLI pepcoil swissprot:MURE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MURE_ECOLI pepdigest swissprot:MURE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MURE_ECOLI pepinfo swissprot:MURE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MURE_ECOLI pepnet swissprot:MURE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MURE_ECOLI pepstats swissprot:MURE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MURE_ECOLI pepwheel swissprot:MURE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MURE_ECOLI pepwindow swissprot:MURE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MURE_ECOLI sigcleave swissprot:MURE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MURE_ECOLI ## Database ID URL or Descriptions # BioGrid 4262717 7 # EcoGene EG12499 yjfY # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GOslim_component GO:0005575 cellular_component # Gene3D 3.30.1660.10 -; 1. # InterPro IPR010854 DUF1471 # InterPro IPR025543 Dodecin-like # Organism YJFY_ECOLI Escherichia coli (strain K12) # PATRIC 32123973 VBIEscCol129921_4331 # PIR S56424 S56424 # Pfam PF07338 DUF1471 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJFY_ECOLI Uncharacterized protein YjfY # RefSeq NP_418620 NC_000913.3 # RefSeq WP_000492914 NZ_LN832404.1 # SIMILARITY Belongs to the BhsA/McbA family. {ECO 0000305}. # SUBCELLULAR LOCATION YJFY_ECOLI Periplasm {ECO 0000305}. # SUPFAM SSF159871 SSF159871 # eggNOG ENOG4105KIT Bacteria # eggNOG ENOG41120AN LUCA BLAST swissprot:YJFY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJFY_ECOLI BioCyc ECOL316407:JW4157-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4157-MONOMER BioCyc EcoCyc:G7861-MONOMER http://biocyc.org/getid?id=EcoCyc:G7861-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2392 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2392 EcoGene EG12499 http://www.ecogene.org/geneInfo.php?eg_id=EG12499 EnsemblBacteria AAC77156 http://www.ensemblgenomes.org/id/AAC77156 EnsemblBacteria AAC77156 http://www.ensemblgenomes.org/id/AAC77156 EnsemblBacteria BAE78200 http://www.ensemblgenomes.org/id/BAE78200 EnsemblBacteria BAE78200 http://www.ensemblgenomes.org/id/BAE78200 EnsemblBacteria BAE78200 http://www.ensemblgenomes.org/id/BAE78200 EnsemblBacteria b4199 http://www.ensemblgenomes.org/id/b4199 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 Gene3D 3.30.1660.10 http://www.cathdb.info/version/latest/superfamily/3.30.1660.10 GeneID 948713 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948713 HOGENOM HOG000117400 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117400&db=HOGENOM6 InterPro IPR010854 http://www.ebi.ac.uk/interpro/entry/IPR010854 InterPro IPR025543 http://www.ebi.ac.uk/interpro/entry/IPR025543 KEGG_Gene ecj:JW4157 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4157 KEGG_Gene eco:b4199 http://www.genome.jp/dbget-bin/www_bget?eco:b4199 OMA VIYINHH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VIYINHH PSORT swissprot:YJFY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJFY_ECOLI PSORT-B swissprot:YJFY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJFY_ECOLI PSORT2 swissprot:YJFY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJFY_ECOLI Pfam PF07338 http://pfam.xfam.org/family/PF07338 Phobius swissprot:YJFY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJFY_ECOLI ProteinModelPortal P0AF86 http://www.proteinmodelportal.org/query/uniprot/P0AF86 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418620 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418620 RefSeq WP_000492914 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000492914 STRING 511145.b4199 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4199&targetmode=cogs SUPFAM SSF159871 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF159871 UniProtKB YJFY_ECOLI http://www.uniprot.org/uniprot/YJFY_ECOLI UniProtKB-AC P0AF86 http://www.uniprot.org/uniprot/P0AF86 charge swissprot:YJFY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJFY_ECOLI eggNOG ENOG4105KIT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KIT eggNOG ENOG41120AN http://eggnogapi.embl.de/nog_data/html/tree/ENOG41120AN epestfind swissprot:YJFY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJFY_ECOLI garnier swissprot:YJFY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJFY_ECOLI helixturnhelix swissprot:YJFY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJFY_ECOLI hmoment swissprot:YJFY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJFY_ECOLI iep swissprot:YJFY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJFY_ECOLI inforesidue swissprot:YJFY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJFY_ECOLI octanol swissprot:YJFY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJFY_ECOLI pepcoil swissprot:YJFY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJFY_ECOLI pepdigest swissprot:YJFY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJFY_ECOLI pepinfo swissprot:YJFY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJFY_ECOLI pepnet swissprot:YJFY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJFY_ECOLI pepstats swissprot:YJFY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJFY_ECOLI pepwheel swissprot:YJFY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJFY_ECOLI pepwindow swissprot:YJFY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJFY_ECOLI sigcleave swissprot:YJFY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJFY_ECOLI ## Database ID URL or Descriptions # AltName MQSR_ECOLI Endoribonuclease MqsR # AltName MQSR_ECOLI Toxin MqsR # AltName Motility quorum-sensing regulator MqsR {ECO:0000303|PubMed 16352847} # BIOPHYSICOCHEMICAL PROPERTIES Temperature dependence: The MqsR-MqsA complex is exceptionally thermostable with a Tm of 83.4 degress Celsius versus 48.1 degress Celsius for MqsR and 61.1 degress Celsius for MqsA. {ECO 0000269|PubMed:23172222}; # BioGrid 4260831 22 # DISRUPTION PHENOTYPE MQSR_ECOLI No loss of ability to form persister cells in MG1655, represses persister cell formation in BW25113. Deletion decreases biofilm formation in LB medium (PubMed 16352847). Deletion has also been shown to increase biofilm formation (PubMed 20105222). Deletion at 48h, in flow cells, leads to a reduction in biomass, substratum coverage and changes the biofilm architecture from a 54 micron thick film with microcolonies to one with nearly no biomass and only a few colonies remaining. Deletion abolishes motility. A double mqsR-mqsA deletion leads to increased rpoS mRNA levels, resulting in increased cyclic-di-GMP levels, increasing stress resistance, increased biofilm formation (PubMed 21516113). The double mutant has increased metabolism and respiration in the presence of the bile acid deoxycholate and consequently grows less well. Decreases cell survival in the presence of 20% deoxycholate (PubMed 25534751). {ECO 0000269|PubMed 16352847, ECO 0000269|PubMed 16768798, ECO 0000269|PubMed 19909729, ECO 0000269|PubMed 20105222, ECO 0000269|PubMed 21516113, ECO 0000269|PubMed 25534751}. # EcoGene EG13023 mqsR # FUNCTION MQSR_ECOLI Initially reported to act as a cotranscription factor with MqsA (PubMed 19690171, PubMed 20105222). Following further experiments, the MqsR-MqsA complex does not bind DNA and all reported data are actually due to a small fraction of free MqsA alone binding DNA. Addition of MqsR to a preformed MqsA-promoter DNA complex causes dissociation of the MqsA-DNA complex, probably causing derepression of MqsA-repressed transcripts. Does not bind DNA in the presence or absence of MqsA (PubMed 23172222). {ECO 0000269|PubMed 19690171, ECO 0000269|PubMed 20105222, ECO 0000269|PubMed 23172222}. # FUNCTION MQSR_ECOLI Toxic component of a type II toxin-antitoxin (TA) module. Plays a significant role in the control of biofilm formation and induction of persister cells in the presence of antibiotics. An mRNA interferase which has been reported to be translation-independent (PubMed 19690171, PubMed 19943910, PubMed 23289863). It has also been reported to be translation- dependent (PubMed 20041169). Cleavage has been reported to occur on either side of G in the sequence GCU (PubMed 19690171). Also reported to cleave after C in GC(A/U) sequences (PubMed 19943910). There are only 14 genes in E.coli W3110 (and probably also MG1655) that do not have a GCU sequence and thus are resistant to the mRNA interferase activity; among these is the gene for toxin GhoT. Overexpression of MqsR causes cessation of cell growth and inhibits cell proliferation via inhibition of translation as well as increasing persister cell formation; these effects are overcome by concomitant or subsequent expression of antitoxin MqsA. Cross- talk can occur between different TA modules. Ectopic expression of this toxin induces transcription of the relBEF TA module operon with specific cleavage of the relBEF mRNA produced (PubMed 23432955). Regulates the expression of GhoT/GhoS, a type V TA module (PubMed 23289863). Persistence depends on toxin GhoT activity, which MqsR controls at the post-transcriptional level by selectively degrading the antitoxin ghoS segment of the ghoST mRNA (PubMed 23289863). Persister cells exhibit antibiotic tolerance without genetic change. Overexpression leads to a dramatic increase in tolerance to the antibiotic ofloxacin. This TA system mediates cell growth during bile acid deoxycholate stress by degrading mRNA for probable deoxycholate-binding protein YgiS; bile acid detergents such as deoxycholate are important for host defense against bacterial growth in the gall bladder and duodenum (PubMed 25534751). {ECO 0000269|PubMed 19690171, ECO 0000269|PubMed 19943910, ECO 0000269|PubMed 20041169, ECO 0000269|PubMed 23289863, ECO 0000269|PubMed 23432955, ECO 0000269|PubMed 25534751}. # GO_function GO:0004521 endoribonuclease activity; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0009372 quorum sensing; IEA:UniProtKB-KW. # GO_process GO:0017148 negative regulation of translation; IDA:EcoCyc. # GO_process GO:0043488 regulation of mRNA stability; IDA:EcoCyc. # GO_process GO:0044010 single-species biofilm formation; IMP:EcoCyc. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IMP:CACAO. # GO_process GO:2000145 regulation of cell motility; IMP:CACAO. # GOslim_function GO:0004518 nuclease activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0042592 homeostatic process # INDUCTION MQSR_ECOLI Induced by amino acid starvation, glucose starvation and when translation is blocked. Also induced by nalidixic acid, azolocillin and H(2)O(2) (PubMed 23289863). It has been suggested that MqsA represses its own operon (PubMed 19690171). Induction is decreased in the absence of the Lon protease suggesting, by homology to other toxin-antitoxin systems, that Lon may degrade the MqsA antitoxin. Transcription is activated by MqsA (PubMed 20105222). A member of the mqsRA operon. Most highly induced gene in persister cells (PubMed 16768798). Degrades its own transcript (PubMed 23172222). This operon induced by ectopic expression of toxins RelE, HicA and YafQ but not by MazF or HicA (PubMed 23432955). {ECO 0000269|PubMed 16768798, ECO 0000269|PubMed 20105222, ECO 0000269|PubMed 23172222, ECO 0000269|PubMed 23289863, ECO 0000269|PubMed 23432955, ECO 0000303|PubMed 19690171}. # IntAct Q46865 10 # InterPro IPR031451 MqsR_toxin # Organism MQSR_ECOLI Escherichia coli (strain K12) # PDB 3HI2 X-ray; 2.00 A; B/D=1-98 # PIR D65089 D65089 # Pfam PF15723 MqsR_toxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName mRNA interferase MqsR {ECO:0000303|PubMed 19690171} # RefSeq NP_417494 NC_000913.3 # RefSeq WP_000415584 NZ_LN832404.1 # SUBUNIT MQSR_ECOLI Might be a dimer (PubMed 19690171). Also reported to be a monomer (PubMed 23172222). Crystallizes as a heterotetramer with MqsA, MqsR-MqsA(2)-MqsR (PubMed 20041169). Purifies as a possible heterohexamer of 2 MqsR dimers and 1 MqsA dimer (PubMed 19690171). When the 2 dissociate the MsqR mRNA interferase becomes active. {ECO 0000269|PubMed 19690171, ECO 0000269|PubMed 20041169, ECO 0000269|PubMed 23172222}. # eggNOG ENOG4105RT5 Bacteria # eggNOG ENOG4111YYW LUCA BLAST swissprot:MQSR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MQSR_ECOLI BioCyc ECOL316407:JW2990-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2990-MONOMER BioCyc EcoCyc:G7572-MONOMER http://biocyc.org/getid?id=EcoCyc:G7572-MONOMER BioCyc MetaCyc:G7572-MONOMER http://biocyc.org/getid?id=MetaCyc:G7572-MONOMER DOI 10.1016/j.bbrc.2009.11.033 http://dx.doi.org/10.1016/j.bbrc.2009.11.033 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nchembio.560 http://dx.doi.org/10.1038/nchembio.560 DOI 10.1074/jbc.M109.032904 http://dx.doi.org/10.1074/jbc.M109.032904 DOI 10.1074/jbc.M112.421008 http://dx.doi.org/10.1074/jbc.M112.421008 DOI 10.1111/1462-2920.12063 http://dx.doi.org/10.1111/1462-2920.12063 DOI 10.1111/1462-2920.12749 http://dx.doi.org/10.1111/1462-2920.12749 DOI 10.1111/j.1365-2958.2009.06969.x http://dx.doi.org/10.1111/j.1365-2958.2009.06969.x DOI 10.1111/j.1462-2920.2009.02147.x http://dx.doi.org/10.1111/j.1462-2920.2009.02147.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.188.1.305-316.2006 http://dx.doi.org/10.1128/JB.188.1.305-316.2006 DOI 10.1186/1471-2180-13-45 http://dx.doi.org/10.1186/1471-2180-13-45 DOI 10.1186/1471-2180-6-53 http://dx.doi.org/10.1186/1471-2180-6-53 DOI 10.1371/journal.ppat.1000706 http://dx.doi.org/10.1371/journal.ppat.1000706 EC_number EC:3.1.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 ENZYME 3.1.-.- http://enzyme.expasy.org/EC/3.1.-.- EchoBASE EB2841 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2841 EcoGene EG13023 http://www.ecogene.org/geneInfo.php?eg_id=EG13023 EnsemblBacteria AAC76058 http://www.ensemblgenomes.org/id/AAC76058 EnsemblBacteria AAC76058 http://www.ensemblgenomes.org/id/AAC76058 EnsemblBacteria BAE77078 http://www.ensemblgenomes.org/id/BAE77078 EnsemblBacteria BAE77078 http://www.ensemblgenomes.org/id/BAE77078 EnsemblBacteria BAE77078 http://www.ensemblgenomes.org/id/BAE77078 EnsemblBacteria b3022 http://www.ensemblgenomes.org/id/b3022 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004521 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004521 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0009372 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009372 GO_process GO:0017148 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017148 GO_process GO:0043488 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043488 GO_process GO:0044010 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044010 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GO_process GO:2000145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000145 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GeneID 947500 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947500 HOGENOM HOG000229187 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000229187&db=HOGENOM6 IntAct Q46865 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46865* IntEnz 3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1 InterPro IPR031451 http://www.ebi.ac.uk/interpro/entry/IPR031451 KEGG_Gene ecj:JW2990 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2990 KEGG_Gene eco:b3022 http://www.genome.jp/dbget-bin/www_bget?eco:b3022 KEGG_Orthology KO:K13651 http://www.genome.jp/dbget-bin/www_bget?KO:K13651 OMA MEKGTPH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MEKGTPH PDB 3HI2 http://www.ebi.ac.uk/pdbe-srv/view/entry/3HI2 PDBsum 3HI2 http://www.ebi.ac.uk/pdbsum/3HI2 PSORT swissprot:MQSR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MQSR_ECOLI PSORT-B swissprot:MQSR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MQSR_ECOLI PSORT2 swissprot:MQSR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MQSR_ECOLI Pfam PF15723 http://pfam.xfam.org/family/PF15723 Phobius swissprot:MQSR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MQSR_ECOLI ProteinModelPortal Q46865 http://www.proteinmodelportal.org/query/uniprot/Q46865 PubMed 16352847 http://www.ncbi.nlm.nih.gov/pubmed/16352847 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16768798 http://www.ncbi.nlm.nih.gov/pubmed/16768798 PubMed 19690171 http://www.ncbi.nlm.nih.gov/pubmed/19690171 PubMed 19909729 http://www.ncbi.nlm.nih.gov/pubmed/19909729 PubMed 19943910 http://www.ncbi.nlm.nih.gov/pubmed/19943910 PubMed 20041169 http://www.ncbi.nlm.nih.gov/pubmed/20041169 PubMed 20105222 http://www.ncbi.nlm.nih.gov/pubmed/20105222 PubMed 21516113 http://www.ncbi.nlm.nih.gov/pubmed/21516113 PubMed 23172222 http://www.ncbi.nlm.nih.gov/pubmed/23172222 PubMed 23289863 http://www.ncbi.nlm.nih.gov/pubmed/23289863 PubMed 23432955 http://www.ncbi.nlm.nih.gov/pubmed/23432955 PubMed 25534751 http://www.ncbi.nlm.nih.gov/pubmed/25534751 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417494 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417494 RefSeq WP_000415584 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000415584 SMR Q46865 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46865 STRING 511145.b3022 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3022&targetmode=cogs UniProtKB MQSR_ECOLI http://www.uniprot.org/uniprot/MQSR_ECOLI UniProtKB-AC Q46865 http://www.uniprot.org/uniprot/Q46865 charge swissprot:MQSR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MQSR_ECOLI eggNOG ENOG4105RT5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105RT5 eggNOG ENOG4111YYW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111YYW epestfind swissprot:MQSR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MQSR_ECOLI garnier swissprot:MQSR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MQSR_ECOLI helixturnhelix swissprot:MQSR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MQSR_ECOLI hmoment swissprot:MQSR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MQSR_ECOLI iep swissprot:MQSR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MQSR_ECOLI inforesidue swissprot:MQSR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MQSR_ECOLI octanol swissprot:MQSR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MQSR_ECOLI pepcoil swissprot:MQSR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MQSR_ECOLI pepdigest swissprot:MQSR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MQSR_ECOLI pepinfo swissprot:MQSR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MQSR_ECOLI pepnet swissprot:MQSR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MQSR_ECOLI pepstats swissprot:MQSR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MQSR_ECOLI pepwheel swissprot:MQSR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MQSR_ECOLI pepwindow swissprot:MQSR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MQSR_ECOLI sigcleave swissprot:MQSR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MQSR_ECOLI ## Database ID URL or Descriptions # AltName SELD_ECOLI Selenium donor protein # AltName SELD_ECOLI Selenophosphate synthase # BRENDA 2.7.9 2026 # BioGrid 4259138 16 # CATALYTIC ACTIVITY SELD_ECOLI ATP + selenide + H(2)O = AMP + selenophosphate + phosphate. # COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI 18420; # EcoGene EG10943 selD # FUNCTION SELD_ECOLI Synthesizes selenophosphate from selenide and ATP. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0004756 selenide, water dikinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_process GO:0016260 selenocysteine biosynthetic process; IMP:EcoCyc. # GO_process GO:0070329 tRNA seleno-modification; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.30.1330.10 -; 1. # Gene3D 3.90.650.10 -; 1. # HAMAP MF_00625 SelD # IntAct P16456 11 # InterPro IPR004536 SPS/SelD # InterPro IPR010918 AIR_synth_C_dom # InterPro IPR016188 PurM-like_N # InterPro IPR023061 SelD_I # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # KEGG_Pathway ko00450 Selenocompound metabolism # Organism SELD_ECOLI Escherichia coli (strain K12) # PATRIC 32118839 VBIEscCol129921_1837 # PDB 3U0O X-ray; 2.25 A; A/B=1-347 # PIR JW0033 JW0033 # PIRSF PIRSF036407 Selenphspht_syn # Pfam PF00586 AIRS # Pfam PF02769 AIRS_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SELD_ECOLI Selenide, water dikinase # RefSeq NP_416278 NC_000913.3 # RefSeq WP_001295485 NZ_LN832404.1 # SIMILARITY Belongs to the selenophosphate synthase 1 family. Class I subfamily. {ECO 0000305}. # SUBUNIT Monomer. {ECO 0000305}. # SUPFAM SSF56042 SSF56042 # TIGRFAMs TIGR00476 selD # eggNOG COG0709 LUCA # eggNOG ENOG4105D4F Bacteria BLAST swissprot:SELD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SELD_ECOLI BioCyc ECOL316407:JW1753-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1753-MONOMER BioCyc EcoCyc:EG10943-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10943-MONOMER BioCyc MetaCyc:EG10943-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10943-MONOMER COG COG0709 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0709 DIP DIP-10849N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10849N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.87.2.543 http://dx.doi.org/10.1073/pnas.87.2.543 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.9.3 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.9.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J05076 http://www.ebi.ac.uk/ena/data/view/J05076 EMBL M30184 http://www.ebi.ac.uk/ena/data/view/M30184 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.9.3 http://enzyme.expasy.org/EC/2.7.9.3 EchoBASE EB0936 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0936 EcoGene EG10943 http://www.ecogene.org/geneInfo.php?eg_id=EG10943 EnsemblBacteria AAC74834 http://www.ensemblgenomes.org/id/AAC74834 EnsemblBacteria AAC74834 http://www.ensemblgenomes.org/id/AAC74834 EnsemblBacteria BAA15552 http://www.ensemblgenomes.org/id/BAA15552 EnsemblBacteria BAA15552 http://www.ensemblgenomes.org/id/BAA15552 EnsemblBacteria BAA15552 http://www.ensemblgenomes.org/id/BAA15552 EnsemblBacteria b1764 http://www.ensemblgenomes.org/id/b1764 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0004756 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004756 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0016260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016260 GO_process GO:0070329 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070329 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.30.1330.10 http://www.cathdb.info/version/latest/superfamily/3.30.1330.10 Gene3D 3.90.650.10 http://www.cathdb.info/version/latest/superfamily/3.90.650.10 GeneID 946768 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946768 HAMAP MF_00625 http://hamap.expasy.org/unirule/MF_00625 HOGENOM HOG000219300 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219300&db=HOGENOM6 InParanoid P16456 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P16456 IntAct P16456 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P16456* IntEnz 2.7.9.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.9.3 InterPro IPR004536 http://www.ebi.ac.uk/interpro/entry/IPR004536 InterPro IPR010918 http://www.ebi.ac.uk/interpro/entry/IPR010918 InterPro IPR016188 http://www.ebi.ac.uk/interpro/entry/IPR016188 InterPro IPR023061 http://www.ebi.ac.uk/interpro/entry/IPR023061 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW1753 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1753 KEGG_Gene eco:b1764 http://www.genome.jp/dbget-bin/www_bget?eco:b1764 KEGG_Orthology KO:K01008 http://www.genome.jp/dbget-bin/www_bget?KO:K01008 KEGG_Pathway ko00450 http://www.genome.jp/kegg-bin/show_pathway?ko00450 KEGG_Reaction rn:R03595 http://www.genome.jp/dbget-bin/www_bget?rn:R03595 MINT MINT-1256873 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1256873 OMA CTLNKPG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CTLNKPG PDB 3U0O http://www.ebi.ac.uk/pdbe-srv/view/entry/3U0O PDBsum 3U0O http://www.ebi.ac.uk/pdbsum/3U0O PSORT swissprot:SELD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SELD_ECOLI PSORT-B swissprot:SELD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SELD_ECOLI PSORT2 swissprot:SELD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SELD_ECOLI Pfam PF00586 http://pfam.xfam.org/family/PF00586 Pfam PF02769 http://pfam.xfam.org/family/PF02769 Phobius swissprot:SELD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SELD_ECOLI PhylomeDB P16456 http://phylomedb.org/?seqid=P16456 ProteinModelPortal P16456 http://www.proteinmodelportal.org/query/uniprot/P16456 PubMed 1527085 http://www.ncbi.nlm.nih.gov/pubmed/1527085 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2405383 http://www.ncbi.nlm.nih.gov/pubmed/2405383 PubMed 2553698 http://www.ncbi.nlm.nih.gov/pubmed/2553698 PubMed 8262938 http://www.ncbi.nlm.nih.gov/pubmed/8262938 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416278 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416278 RefSeq WP_001295485 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295485 SMR P16456 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P16456 STRING 511145.b1764 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1764&targetmode=cogs STRING COG0709 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0709&targetmode=cogs SUPFAM SSF56042 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56042 TIGRFAMs TIGR00476 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00476 UniProtKB SELD_ECOLI http://www.uniprot.org/uniprot/SELD_ECOLI UniProtKB-AC P16456 http://www.uniprot.org/uniprot/P16456 charge swissprot:SELD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SELD_ECOLI eggNOG COG0709 http://eggnogapi.embl.de/nog_data/html/tree/COG0709 eggNOG ENOG4105D4F http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D4F epestfind swissprot:SELD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SELD_ECOLI garnier swissprot:SELD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SELD_ECOLI helixturnhelix swissprot:SELD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SELD_ECOLI hmoment swissprot:SELD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SELD_ECOLI iep swissprot:SELD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SELD_ECOLI inforesidue swissprot:SELD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SELD_ECOLI octanol swissprot:SELD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SELD_ECOLI pepcoil swissprot:SELD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SELD_ECOLI pepdigest swissprot:SELD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SELD_ECOLI pepinfo swissprot:SELD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SELD_ECOLI pepnet swissprot:SELD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SELD_ECOLI pepstats swissprot:SELD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SELD_ECOLI pepwheel swissprot:SELD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SELD_ECOLI pepwindow swissprot:SELD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SELD_ECOLI sigcleave swissprot:SELD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SELD_ECOLI ## Database ID URL or Descriptions # AltName Undecaprenyl-phosphate GlcNAc-1-phosphate transferase {ECO:0000255|HAMAP-Rule MF_02030} # AltName WECA_ECOLI UDP-GlcNAc undecaprenyl-phosphate GlcNAc-1-phosphate transferase {ECO 0000255|HAMAP-Rule MF_02030, ECO 0000303|PubMed 1730666} # BIOPHYSICOCHEMICAL PROPERTIES WECA_ECOLI Kinetic parameters KM=5.6 uM for UDP-GlcNAc {ECO 0000269|PubMed 9134438}; KM=0.12 uM for UDP-GlcNAc (in the presence of Mg(2+)) {ECO 0000269|PubMed 17237164}; KM=0.19 uM for UDP-GlcNAc (in the presence of Mn(2+)) {ECO 0000269|PubMed 17237164}; KM=1.7 mM for Mg(2+) {ECO 0000269|PubMed 17237164}; KM=0.3 mM for Mn(2+) {ECO 0000269|PubMed 17237164}; Vmax=57 pmol/min/mg enzyme (in the presence of Mg(2+)) {ECO 0000269|PubMed 17237164}; Vmax=56 pmol/min/mg enzyme (in the presence of Mn(2+)) {ECO 0000269|PubMed 17237164}; # BRENDA 2.7.8.33 2026 # BioGrid 4263322 310 # CATALYTIC ACTIVITY WECA_ECOLI UDP-N-acetyl-alpha-D-glucosamine + ditrans,octacis-undecaprenyl phosphate = UMP + N-acetyl-alpha-D- glucosaminyl-diphospho-ditrans,octacis-undecaprenol. {ECO 0000255|HAMAP-Rule MF_02030, ECO 0000269|PubMed 17237164, ECO 0000269|PubMed 9134438}. # COFACTOR WECA_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_02030, ECO 0000269|PubMed 17237164}; # COFACTOR WECA_ECOLI Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000255|HAMAP-Rule MF_02030, ECO 0000269|PubMed 17237164}; # ENZYME REGULATION WECA_ECOLI Inhibited by tunicamycin. # EcoGene EG10840 wecA # FUNCTION WECA_ECOLI Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP- C55). It is the first lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis, and an acceptor for the addition of subsequent sugars to complete the biosynthesis of O-antigen lipopolysaccharide (LPS) in many E.coli O types. The apparent affinity of WecA for the polyisoprenyl phosphate substrates increases with the polyisoprenyl chain length. WecA is unable to utilize dolichyl phosphate (Dol-P). {ECO 0000269|PubMed 11700352, ECO 0000269|PubMed 17237164, ECO 0000269|PubMed 1730666, ECO 0000269|PubMed 9134438}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IMP:UniProtKB. # GO_component GO:0009276 Gram-negative-bacterium-type cell wall; IDA:UniProtKB. # GO_component GO:0016020 membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IDA:EcoliWiki. # GO_function GO:0000287 magnesium ion binding; IDA:UniProtKB. # GO_function GO:0008144 drug binding; IDA:EcoliWiki. # GO_function GO:0008963 phospho-N-acetylmuramoyl-pentapeptide-transferase activity; IDA:EcoliWiki. # GO_function GO:0016757 transferase activity, transferring glycosyl groups; IEA:UniProtKB-KW. # GO_function GO:0016780 phosphotransferase activity, for other substituted phosphate groups; IDA:UniProtKB. # GO_function GO:0030145 manganese ion binding; IDA:UniProtKB. # GO_function GO:0036380 UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IDA:UniProtKB. # GO_process GO:0009243 O antigen biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0009246 enterobacterial common antigen biosynthetic process; IMP:EcoCyc. # GO_process GO:0044038 cell wall macromolecule biosynthetic process; IDA:UniProtKB. # GO_process GO:0071555 cell wall organization; IDA:UniProtKB. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005618 cell wall # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0071554 cell wall organization or biogenesis # HAMAP MF_02030 WecA_Gammaproteo # InterPro IPR000715 Glycosyl_transferase_4 # InterPro IPR012750 ECA_WecA-rel # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01003 Glycosyltransferases # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # Organism WECA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR22926 PTHR22926 # PATHWAY WECA_ECOLI Bacterial outer membrane biogenesis; LPS O-antigen biosynthesis. {ECO 0000255|HAMAP-Rule MF_02030, ECO 0000269|PubMed 11700352}. # PATHWAY WECA_ECOLI Bacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis. {ECO 0000255|HAMAP-Rule MF_02030, ECO 0000269|PubMed 1730666}. # PATRIC 32123061 VBIEscCol129921_3900 # PIR C65182 C65182 # Pfam PF00953 Glycos_transf_4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase {ECO:0000255|HAMAP-Rule MF_02030, ECO:0000305} # RefSeq NP_418231 NC_000913.3 # RefSeq WP_001050960 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA24526.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAB20842.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the glycosyltransferase 4 family. WecA subfamily. {ECO:0000255|HAMAP-Rule MF_02030, ECO:0000305}. # SUBCELLULAR LOCATION WECA_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_02030, ECO 0000269|PubMed 11700352, ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 17237164}; Multi- pass membrane protein {ECO 0000255|HAMAP-Rule MF_02030}. Note=Localizes to discrete regions in the plasma membrane. {ECO 0000269|PubMed 17237164}. # TCDB 9.B.146.1 the putative undecaprenyl-phosphate n-acetylglucosaminyl transferase (murg) family # TIGRFAMs TIGR02380 ECA_wecA # eggNOG COG0472 LUCA # eggNOG ENOG4105ESV Bacteria BLAST swissprot:WECA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:WECA_ECOLI BioCyc ECOL316407:JW3758-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3758-MONOMER BioCyc EcoCyc:GLCNACPTRANS-MONOMER http://biocyc.org/getid?id=EcoCyc:GLCNACPTRANS-MONOMER BioCyc MetaCyc:GLCNACPTRANS-MONOMER http://biocyc.org/getid?id=MetaCyc:GLCNACPTRANS-MONOMER COG COG0472 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0472 DIP DIP-48083N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48083N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/glycob/7.2.315 http://dx.doi.org/10.1093/glycob/7.2.315 DOI 10.1111/j.1365-2958.1991.tb00809.x http://dx.doi.org/10.1111/j.1365-2958.1991.tb00809.x DOI 10.1111/j.1574-6968.2000.tb09335.x http://dx.doi.org/10.1111/j.1574-6968.2000.tb09335.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01905-06 http://dx.doi.org/10.1128/JB.01905-06 DOI 10.1128/JB.182.2.498-503.2000 http://dx.doi.org/10.1128/JB.182.2.498-503.2000 EC_number EC:2.7.8.33 {ECO:0000255|HAMAP-Rule:MF_02030, ECO:0000269|PubMed:17237164, ECO:0000269|PubMed:9134438} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.8.33 {ECO:0000255|HAMAP-Rule:MF_02030, ECO:0000269|PubMed:17237164, ECO:0000269|PubMed:9134438} EMBL AF248031 http://www.ebi.ac.uk/ena/data/view/AF248031 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M76129 http://www.ebi.ac.uk/ena/data/view/M76129 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL S75640 http://www.ebi.ac.uk/ena/data/view/S75640 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.8.33 {ECO:0000255|HAMAP-Rule:MF_02030, ECO:0000269|PubMed:17237164, ECO:0000269|PubMed:9134438} http://enzyme.expasy.org/EC/2.7.8.33 {ECO:0000255|HAMAP-Rule:MF_02030, ECO:0000269|PubMed:17237164, ECO:0000269|PubMed:9134438} EchoBASE EB0833 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0833 EcoGene EG10840 http://www.ecogene.org/geneInfo.php?eg_id=EG10840 EnsemblBacteria AAC76789 http://www.ensemblgenomes.org/id/AAC76789 EnsemblBacteria AAC76789 http://www.ensemblgenomes.org/id/AAC76789 EnsemblBacteria BAE77514 http://www.ensemblgenomes.org/id/BAE77514 EnsemblBacteria BAE77514 http://www.ensemblgenomes.org/id/BAE77514 EnsemblBacteria BAE77514 http://www.ensemblgenomes.org/id/BAE77514 EnsemblBacteria b3784 http://www.ensemblgenomes.org/id/b3784 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0009276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009276 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0008144 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008144 GO_function GO:0008963 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008963 GO_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GO_function GO:0016780 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016780 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_function GO:0036380 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036380 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GO_process GO:0009243 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009243 GO_process GO:0009246 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009246 GO_process GO:0044038 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044038 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005618 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 GeneID 948789 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948789 HAMAP MF_02030 http://hamap.expasy.org/unirule/MF_02030 HOGENOM HOG000275125 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275125&db=HOGENOM6 InParanoid P0AC78 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AC78 IntAct P0AC78 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AC78* IntEnz 2.7.8.33 {ECO:0000255|HAMAP-Rule:MF_02030, ECO:0000269|PubMed:17237164, ECO:0000269|PubMed:9134438} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.8.33 {ECO:0000255|HAMAP-Rule:MF_02030, ECO:0000269|PubMed:17237164, ECO:0000269|PubMed:9134438} InterPro IPR000715 http://www.ebi.ac.uk/interpro/entry/IPR000715 InterPro IPR012750 http://www.ebi.ac.uk/interpro/entry/IPR012750 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01003 http://www.genome.jp/dbget-bin/www_bget?ko01003 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Gene ecj:JW3758 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3758 KEGG_Gene eco:b3784 http://www.genome.jp/dbget-bin/www_bget?eco:b3784 KEGG_Orthology KO:K02851 http://www.genome.jp/dbget-bin/www_bget?KO:K02851 KEGG_Reaction rn:R08856 http://www.genome.jp/dbget-bin/www_bget?rn:R08856 OMA LPHNFQP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LPHNFQP PANTHER PTHR22926 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22926 PSORT swissprot:WECA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:WECA_ECOLI PSORT-B swissprot:WECA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:WECA_ECOLI PSORT2 swissprot:WECA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:WECA_ECOLI Pfam PF00953 http://pfam.xfam.org/family/PF00953 Phobius swissprot:WECA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:WECA_ECOLI PhylomeDB P0AC78 http://phylomedb.org/?seqid=P0AC78 ProteinModelPortal P0AC78 http://www.proteinmodelportal.org/query/uniprot/P0AC78 PubMed 10629198 http://www.ncbi.nlm.nih.gov/pubmed/10629198 PubMed 11024259 http://www.ncbi.nlm.nih.gov/pubmed/11024259 PubMed 11700352 http://www.ncbi.nlm.nih.gov/pubmed/11700352 PubMed 11832520 http://www.ncbi.nlm.nih.gov/pubmed/11832520 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1722555 http://www.ncbi.nlm.nih.gov/pubmed/1722555 PubMed 17237164 http://www.ncbi.nlm.nih.gov/pubmed/17237164 PubMed 1730666 http://www.ncbi.nlm.nih.gov/pubmed/1730666 PubMed 9134438 http://www.ncbi.nlm.nih.gov/pubmed/9134438 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418231 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418231 RefSeq WP_001050960 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001050960 STRING 511145.b3784 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3784&targetmode=cogs STRING COG0472 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0472&targetmode=cogs TCDB 9.B.146.1 http://www.tcdb.org/search/result.php?tc=9.B.146.1 TIGRFAMs TIGR02380 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02380 UniProtKB WECA_ECOLI http://www.uniprot.org/uniprot/WECA_ECOLI UniProtKB-AC P0AC78 http://www.uniprot.org/uniprot/P0AC78 charge swissprot:WECA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:WECA_ECOLI eggNOG COG0472 http://eggnogapi.embl.de/nog_data/html/tree/COG0472 eggNOG ENOG4105ESV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ESV epestfind swissprot:WECA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:WECA_ECOLI garnier swissprot:WECA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:WECA_ECOLI helixturnhelix swissprot:WECA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:WECA_ECOLI hmoment swissprot:WECA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:WECA_ECOLI iep swissprot:WECA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:WECA_ECOLI inforesidue swissprot:WECA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:WECA_ECOLI octanol swissprot:WECA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:WECA_ECOLI pepcoil swissprot:WECA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:WECA_ECOLI pepdigest swissprot:WECA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:WECA_ECOLI pepinfo swissprot:WECA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:WECA_ECOLI pepnet swissprot:WECA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:WECA_ECOLI pepstats swissprot:WECA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:WECA_ECOLI pepwheel swissprot:WECA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:WECA_ECOLI pepwindow swissprot:WECA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:WECA_ECOLI sigcleave swissprot:WECA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:WECA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259415 104 # CDD cd06174 MFS # EcoGene EG13487 ydjK # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IBA:GO_Central. # GO_function GO:0022891 substrate-specific transmembrane transporter activity; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # InterPro IPR005828 MFS_sugar_transport-like # InterPro IPR020846 MFS_dom # KEGG_Brite ko02000 Transporters # Organism YDJK_ECOLI Escherichia coli (strain K12) # PATRIC 32118861 VBIEscCol129921_1848 # PIR G64937 G64937 # PROSITE PS50850 MFS # Pfam PF00083 Sugar_tr # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDJK_ECOLI Putative metabolite transport protein YdjK # RefSeq NP_416289 NC_000913.3 # RefSeq WP_000435292 NZ_LN832404.1 # SIMILARITY Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. {ECO 0000305}. # SUBCELLULAR LOCATION YDJK_ECOLI Cell inner membrane {ECO 0000305}; Multi- pass membrane protein {ECO 0000305}. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.1.115 the major facilitator superfamily (mfs) # eggNOG ENOG4107TE1 Bacteria # eggNOG ENOG410ZVY1 LUCA BLAST swissprot:YDJK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDJK_ECOLI BioCyc ECOL316407:JW5290-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5290-MONOMER BioCyc EcoCyc:B1775-MONOMER http://biocyc.org/getid?id=EcoCyc:B1775-MONOMER COG COG0477 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0477 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3260 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3260 EcoGene EG13487 http://www.ecogene.org/geneInfo.php?eg_id=EG13487 EnsemblBacteria AAC74845 http://www.ensemblgenomes.org/id/AAC74845 EnsemblBacteria AAC74845 http://www.ensemblgenomes.org/id/AAC74845 EnsemblBacteria BAA15573 http://www.ensemblgenomes.org/id/BAA15573 EnsemblBacteria BAA15573 http://www.ensemblgenomes.org/id/BAA15573 EnsemblBacteria BAA15573 http://www.ensemblgenomes.org/id/BAA15573 EnsemblBacteria b1775 http://www.ensemblgenomes.org/id/b1775 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0022891 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022891 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GeneID 946293 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946293 HOGENOM HOG000114540 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000114540&db=HOGENOM6 InParanoid P76230 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76230 InterPro IPR005828 http://www.ebi.ac.uk/interpro/entry/IPR005828 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5290 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5290 KEGG_Gene eco:b1775 http://www.genome.jp/dbget-bin/www_bget?eco:b1775 KEGG_Orthology KO:K08369 http://www.genome.jp/dbget-bin/www_bget?KO:K08369 OMA DICTADH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DICTADH PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:YDJK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDJK_ECOLI PSORT-B swissprot:YDJK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDJK_ECOLI PSORT2 swissprot:YDJK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDJK_ECOLI Pfam PF00083 http://pfam.xfam.org/family/PF00083 Phobius swissprot:YDJK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDJK_ECOLI PhylomeDB P76230 http://phylomedb.org/?seqid=P76230 ProteinModelPortal P76230 http://www.proteinmodelportal.org/query/uniprot/P76230 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416289 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416289 RefSeq WP_000435292 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000435292 STRING 511145.b1775 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1775&targetmode=cogs STRING COG0477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0477&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.1.115 http://www.tcdb.org/search/result.php?tc=2.A.1.1.115 UniProtKB YDJK_ECOLI http://www.uniprot.org/uniprot/YDJK_ECOLI UniProtKB-AC P76230 http://www.uniprot.org/uniprot/P76230 charge swissprot:YDJK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDJK_ECOLI eggNOG ENOG4107TE1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107TE1 eggNOG ENOG410ZVY1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZVY1 epestfind swissprot:YDJK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDJK_ECOLI garnier swissprot:YDJK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDJK_ECOLI helixturnhelix swissprot:YDJK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDJK_ECOLI hmoment swissprot:YDJK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDJK_ECOLI iep swissprot:YDJK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDJK_ECOLI inforesidue swissprot:YDJK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDJK_ECOLI octanol swissprot:YDJK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDJK_ECOLI pepcoil swissprot:YDJK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDJK_ECOLI pepdigest swissprot:YDJK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDJK_ECOLI pepinfo swissprot:YDJK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDJK_ECOLI pepnet swissprot:YDJK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDJK_ECOLI pepstats swissprot:YDJK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDJK_ECOLI pepwheel swissprot:YDJK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDJK_ECOLI pepwindow swissprot:YDJK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDJK_ECOLI sigcleave swissprot:YDJK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDJK_ECOLI ## Database ID URL or Descriptions # AltName YGHD_ECOLI Putative extracytoplasmic function protein C # AltName YGHD_ECOLI Putative general secretion pathway M-type protein YghD # BioGrid 4262353 1187 # EcoGene EG12988 yghD # FUNCTION YGHD_ECOLI Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. {ECO 0000250}. # GO_component GO:0005576 extracellular region; IEA:GOC. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006858 extracellular transport; IEA:InterPro. # GO_process GO:0015031 protein transport; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005576 extracellular region # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006810 transport # Gene3D 3.30.1360.100 -; 1. # InterPro IPR007690 T2SS_M # InterPro IPR023229 T2SS_M_periplasmic # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02044 M00331 Type II general secretion system # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko03070 Bacterial secretion system # Organism YGHD_ECOLI Escherichia coli (strain K12) # PATRIC 32121352 VBIEscCol129921_3063 # PIR F65082 F65082 # PIRSF PIRSF006291 GspM # Pfam PF04612 T2SSM # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGHD_ECOLI Putative type II secretion system M-type protein YghD # RefSeq NP_417442 NC_000913.3 # RefSeq WP_000942785 NZ_LN832404.1 # SIMILARITY Belongs to the GSP M family. {ECO 0000305}. # SUBCELLULAR LOCATION YGHD_ECOLI Cell inner membrane {ECO 0000305}; Single- pass membrane protein {ECO 0000305}. # SUPFAM SSF103054 SSF103054 # eggNOG COG3149 LUCA # eggNOG ENOG4105U1E Bacteria BLAST swissprot:YGHD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGHD_ECOLI BioCyc ECOL316407:JW2935-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2935-MONOMER BioCyc EcoCyc:G7535-MONOMER http://biocyc.org/getid?id=EcoCyc:G7535-MONOMER COG COG3149 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3149 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2812 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2812 EcoGene EG12988 http://www.ecogene.org/geneInfo.php?eg_id=EG12988 EnsemblBacteria AAC76004 http://www.ensemblgenomes.org/id/AAC76004 EnsemblBacteria AAC76004 http://www.ensemblgenomes.org/id/AAC76004 EnsemblBacteria BAE77030 http://www.ensemblgenomes.org/id/BAE77030 EnsemblBacteria BAE77030 http://www.ensemblgenomes.org/id/BAE77030 EnsemblBacteria BAE77030 http://www.ensemblgenomes.org/id/BAE77030 EnsemblBacteria b2968 http://www.ensemblgenomes.org/id/b2968 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005576 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006858 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006858 GO_process GO:0015031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005576 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.30.1360.100 http://www.cathdb.info/version/latest/superfamily/3.30.1360.100 GeneID 947025 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947025 HOGENOM HOG000124859 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000124859&db=HOGENOM6 InParanoid Q46832 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46832 InterPro IPR007690 http://www.ebi.ac.uk/interpro/entry/IPR007690 InterPro IPR023229 http://www.ebi.ac.uk/interpro/entry/IPR023229 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW2935 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2935 KEGG_Gene eco:b2968 http://www.genome.jp/dbget-bin/www_bget?eco:b2968 KEGG_Orthology KO:K02462 http://www.genome.jp/dbget-bin/www_bget?KO:K02462 KEGG_Pathway ko03070 http://www.genome.jp/kegg-bin/show_pathway?ko03070 OMA PQGNKIQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PQGNKIQ PSORT swissprot:YGHD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGHD_ECOLI PSORT-B swissprot:YGHD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGHD_ECOLI PSORT2 swissprot:YGHD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGHD_ECOLI Pfam PF04612 http://pfam.xfam.org/family/PF04612 Phobius swissprot:YGHD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGHD_ECOLI ProteinModelPortal Q46832 http://www.proteinmodelportal.org/query/uniprot/Q46832 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417442 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417442 RefSeq WP_000942785 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000942785 SMR Q46832 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46832 STRING 511145.b2968 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2968&targetmode=cogs STRING COG3149 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3149&targetmode=cogs SUPFAM SSF103054 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103054 UniProtKB YGHD_ECOLI http://www.uniprot.org/uniprot/YGHD_ECOLI UniProtKB-AC Q46832 http://www.uniprot.org/uniprot/Q46832 charge swissprot:YGHD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGHD_ECOLI eggNOG COG3149 http://eggnogapi.embl.de/nog_data/html/tree/COG3149 eggNOG ENOG4105U1E http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105U1E epestfind swissprot:YGHD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGHD_ECOLI garnier swissprot:YGHD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGHD_ECOLI helixturnhelix swissprot:YGHD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGHD_ECOLI hmoment swissprot:YGHD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGHD_ECOLI iep swissprot:YGHD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGHD_ECOLI inforesidue swissprot:YGHD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGHD_ECOLI octanol swissprot:YGHD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGHD_ECOLI pepcoil swissprot:YGHD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGHD_ECOLI pepdigest swissprot:YGHD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGHD_ECOLI pepinfo swissprot:YGHD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGHD_ECOLI pepnet swissprot:YGHD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGHD_ECOLI pepstats swissprot:YGHD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGHD_ECOLI pepwheel swissprot:YGHD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGHD_ECOLI pepwindow swissprot:YGHD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGHD_ECOLI sigcleave swissprot:YGHD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGHD_ECOLI ## Database ID URL or Descriptions # AltName IRAM_ECOLI Enhancing lycopene biosynthesis protein 1 # BioGrid 4262861 12 # EcoGene EG13885 elbA # FUNCTION IRAM_ECOLI Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during magnesium starvation. May also be involved in the early steps of isoprenoid biosynthesis, possibly through its role as RssB regulator. {ECO 0000269|PubMed 18383615}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0043856 anti-sigma factor antagonist activity; IDA:EcoCyc. # GO_process GO:0010350 cellular response to magnesium starvation; IMP:EcoCyc. # GO_process GO:0042177 negative regulation of protein catabolic process; IDA:EcoCyc. # GO_process GO:0071468 cellular response to acidic pH; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0000988 transcription factor activity, protein binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # HAMAP MF_01199 Anti_adapt_IraM # INDUCTION By magnesium and calcium starvation, via the transcriptional regulator PhoP. {ECO:0000269|PubMed 18383615}. # InterPro IPR014448 Anti-adapter_IraM # Organism IRAM_ECOLI Escherichia coli (strain K12) # PIR E64861 E64861 # PIRSF PIRSF007036 Elb1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName IRAM_ECOLI Anti-adapter protein IraM # RefSeq NP_415678 NC_000913.3 # RefSeq WP_001295666 NZ_LN832404.1 # SIMILARITY Belongs to the IraM/RssC family. {ECO 0000305}. # SUBCELLULAR LOCATION IRAM_ECOLI Cytoplasm {ECO 0000305}. # eggNOG ENOG41066T8 Bacteria # eggNOG ENOG41125KS LUCA BLAST swissprot:IRAM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:IRAM_ECOLI BioCyc ECOL316407:JW1147-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1147-MONOMER BioCyc EcoCyc:G6600-MONOMER http://biocyc.org/getid?id=EcoCyc:G6600-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/oxfordjournals.jbchem.a022047 http://dx.doi.org/10.1093/oxfordjournals.jbchem.a022047 DOI 10.1111/j.1365-2958.2004.04125.x http://dx.doi.org/10.1111/j.1365-2958.2004.04125.x DOI 10.1111/j.1365-2958.2008.06146.x http://dx.doi.org/10.1111/j.1365-2958.2008.06146.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3644 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3644 EcoGene EG13885 http://www.ecogene.org/geneInfo.php?eg_id=EG13885 EnsemblBacteria AAC74244 http://www.ensemblgenomes.org/id/AAC74244 EnsemblBacteria AAC74244 http://www.ensemblgenomes.org/id/AAC74244 EnsemblBacteria BAE76383 http://www.ensemblgenomes.org/id/BAE76383 EnsemblBacteria BAE76383 http://www.ensemblgenomes.org/id/BAE76383 EnsemblBacteria BAE76383 http://www.ensemblgenomes.org/id/BAE76383 EnsemblBacteria b1160 http://www.ensemblgenomes.org/id/b1160 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0043856 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043856 GO_process GO:0010350 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010350 GO_process GO:0042177 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042177 GO_process GO:0071468 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071468 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0000988 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000988 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 945729 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945729 HAMAP MF_01199 http://hamap.expasy.org/unirule/MF_01199 HOGENOM HOG000050886 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000050886&db=HOGENOM6 IntAct P75987 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75987* InterPro IPR014448 http://www.ebi.ac.uk/interpro/entry/IPR014448 KEGG_Gene ecj:JW1147 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1147 KEGG_Gene eco:b1160 http://www.genome.jp/dbget-bin/www_bget?eco:b1160 OMA FSAIWGD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FSAIWGD PSORT swissprot:IRAM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:IRAM_ECOLI PSORT-B swissprot:IRAM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:IRAM_ECOLI PSORT2 swissprot:IRAM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:IRAM_ECOLI Phobius swissprot:IRAM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:IRAM_ECOLI ProteinModelPortal P75987 http://www.proteinmodelportal.org/query/uniprot/P75987 PubMed 15225322 http://www.ncbi.nlm.nih.gov/pubmed/15225322 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18383615 http://www.ncbi.nlm.nih.gov/pubmed/18383615 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9603997 http://www.ncbi.nlm.nih.gov/pubmed/9603997 RefSeq NP_415678 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415678 RefSeq WP_001295666 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295666 STRING 511145.b1160 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1160&targetmode=cogs UniProtKB IRAM_ECOLI http://www.uniprot.org/uniprot/IRAM_ECOLI UniProtKB-AC P75987 http://www.uniprot.org/uniprot/P75987 charge swissprot:IRAM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:IRAM_ECOLI eggNOG ENOG41066T8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41066T8 eggNOG ENOG41125KS http://eggnogapi.embl.de/nog_data/html/tree/ENOG41125KS epestfind swissprot:IRAM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:IRAM_ECOLI garnier swissprot:IRAM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:IRAM_ECOLI helixturnhelix swissprot:IRAM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:IRAM_ECOLI hmoment swissprot:IRAM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:IRAM_ECOLI iep swissprot:IRAM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:IRAM_ECOLI inforesidue swissprot:IRAM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:IRAM_ECOLI octanol swissprot:IRAM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:IRAM_ECOLI pepcoil swissprot:IRAM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:IRAM_ECOLI pepdigest swissprot:IRAM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:IRAM_ECOLI pepinfo swissprot:IRAM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:IRAM_ECOLI pepnet swissprot:IRAM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:IRAM_ECOLI pepstats swissprot:IRAM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:IRAM_ECOLI pepwheel swissprot:IRAM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:IRAM_ECOLI pepwindow swissprot:IRAM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:IRAM_ECOLI sigcleave swissprot:IRAM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:IRAM_ECOLI ## Database ID URL or Descriptions # BioGrid 4260619 639 # EcoGene EG12097 yfiH # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0005507 copper ion binding; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0043167 ion binding # Gene3D 3.60.140.10 -; 1. # IntAct P33644 8 # InterPro IPR003730 Cu_polyphenol_OxRdtase_Laccase # InterPro IPR011324 Cytotoxic_necrot_fac-like_cat # Organism YFIH_ECOLI Escherichia coli (strain K12) # PATRIC 32120589 VBIEscCol129921_2693 # PDB 1Z9T X-ray; 1.54 A; A=1-243 # PIR D65037 D65037 # Pfam PF02578 Cu-oxidase_4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFIH_ECOLI Laccase domain protein YfiH # RefSeq NP_417084 NC_000913.3 # RefSeq WP_000040169 NZ_LN832404.1 # SIMILARITY Belongs to the LACC1 family. {ECO 0000305}. # SUPFAM SSF64438 SSF64438 # TIGRFAMs TIGR00726 TIGR00726 # eggNOG COG1496 LUCA # eggNOG ENOG4105DBW Bacteria BLAST swissprot:YFIH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFIH_ECOLI BioCyc ECOL316407:JW2575-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2575-MONOMER BioCyc EcoCyc:EG12097-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12097-MONOMER BioCyc MetaCyc:EG12097-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12097-MONOMER COG COG1496 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1496 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M29364 http://www.ebi.ac.uk/ena/data/view/M29364 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U50134 http://www.ebi.ac.uk/ena/data/view/U50134 EMBL X57620 http://www.ebi.ac.uk/ena/data/view/X57620 EchoBASE EB2021 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2021 EcoGene EG12097 http://www.ecogene.org/geneInfo.php?eg_id=EG12097 EnsemblBacteria AAC75642 http://www.ensemblgenomes.org/id/AAC75642 EnsemblBacteria AAC75642 http://www.ensemblgenomes.org/id/AAC75642 EnsemblBacteria BAA16477 http://www.ensemblgenomes.org/id/BAA16477 EnsemblBacteria BAA16477 http://www.ensemblgenomes.org/id/BAA16477 EnsemblBacteria BAA16477 http://www.ensemblgenomes.org/id/BAA16477 EnsemblBacteria b2593 http://www.ensemblgenomes.org/id/b2593 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0005507 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005507 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.60.140.10 http://www.cathdb.info/version/latest/superfamily/3.60.140.10 GeneID 947089 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947089 HOGENOM HOG000242994 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000242994&db=HOGENOM6 InParanoid P33644 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33644 IntAct P33644 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33644* InterPro IPR003730 http://www.ebi.ac.uk/interpro/entry/IPR003730 InterPro IPR011324 http://www.ebi.ac.uk/interpro/entry/IPR011324 KEGG_Gene ecj:JW2575 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2575 KEGG_Gene eco:b2593 http://www.genome.jp/dbget-bin/www_bget?eco:b2593 KEGG_Orthology KO:K05810 http://www.genome.jp/dbget-bin/www_bget?KO:K05810 OMA VVMTADC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VVMTADC PDB 1Z9T http://www.ebi.ac.uk/pdbe-srv/view/entry/1Z9T PDBsum 1Z9T http://www.ebi.ac.uk/pdbsum/1Z9T PSORT swissprot:YFIH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFIH_ECOLI PSORT-B swissprot:YFIH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFIH_ECOLI PSORT2 swissprot:YFIH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFIH_ECOLI Pfam PF02578 http://pfam.xfam.org/family/PF02578 Phobius swissprot:YFIH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFIH_ECOLI PhylomeDB P33644 http://phylomedb.org/?seqid=P33644 ProteinModelPortal P33644 http://www.proteinmodelportal.org/query/uniprot/P33644 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1906060 http://www.ncbi.nlm.nih.gov/pubmed/1906060 PubMed 2066329 http://www.ncbi.nlm.nih.gov/pubmed/2066329 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417084 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417084 RefSeq WP_000040169 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000040169 SMR P33644 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33644 STRING 511145.b2593 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2593&targetmode=cogs STRING COG1496 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1496&targetmode=cogs SUPFAM SSF64438 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF64438 TIGRFAMs TIGR00726 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00726 UniProtKB YFIH_ECOLI http://www.uniprot.org/uniprot/YFIH_ECOLI UniProtKB-AC P33644 http://www.uniprot.org/uniprot/P33644 charge swissprot:YFIH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFIH_ECOLI eggNOG COG1496 http://eggnogapi.embl.de/nog_data/html/tree/COG1496 eggNOG ENOG4105DBW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DBW epestfind swissprot:YFIH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFIH_ECOLI garnier swissprot:YFIH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFIH_ECOLI helixturnhelix swissprot:YFIH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFIH_ECOLI hmoment swissprot:YFIH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFIH_ECOLI iep swissprot:YFIH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFIH_ECOLI inforesidue swissprot:YFIH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFIH_ECOLI octanol swissprot:YFIH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFIH_ECOLI pepcoil swissprot:YFIH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFIH_ECOLI pepdigest swissprot:YFIH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFIH_ECOLI pepinfo swissprot:YFIH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFIH_ECOLI pepnet swissprot:YFIH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFIH_ECOLI pepstats swissprot:YFIH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFIH_ECOLI pepwheel swissprot:YFIH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFIH_ECOLI pepwindow swissprot:YFIH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFIH_ECOLI sigcleave swissprot:YFIH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFIH_ECOLI ## Database ID URL or Descriptions # BioGrid 4261244 129 # EcoGene EG13399 fdrA # FUNCTION FDRA_ECOLI Not known; multicopy suppressor of dominant negative ftsH mutations. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0009361 succinate-CoA ligase complex (ADP-forming); IBA:GO_Central. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0004775 succinate-CoA ligase (ADP-forming) activity; IBA:GO_Central. # GO_function GO:0048037 cofactor binding; IEA:InterPro. # GO_process GO:0006099 tricarboxylic acid cycle; IBA:GO_Central. # GO_process GO:0006104 succinyl-CoA metabolic process; IBA:GO_Central. # GO_process GO:0006105 succinate metabolic process; IBA:GO_Central. # GO_process GO:0009142 nucleoside triphosphate biosynthetic process; IBA:GO_Central. # GO_process GO:0071973 bacterial-type flagellum-dependent cell motility; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016874 ligase activity # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0048870 cell motility # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.261 -; 1. # IntAct Q47208 3 # InterPro IPR003781 CoA-bd # InterPro IPR005811 CoA_ligase # InterPro IPR016102 Succinyl-CoA_synth-like # Organism FDRA_ECOLI Escherichia coli (strain K12) # PATRIC 32116193 VBIEscCol129921_0538 # PDB 3DMY X-ray; 2.07 A; A/B=82-555 # PIR S60201 S60201 # Pfam PF00549 Ligase_CoA # Pfam PF02629 CoA_binding # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FDRA_ECOLI Protein FdrA # RefSeq NP_415051 NC_000913.3 # RefSeq WP_000580829 NZ_LN832404.1 # SIMILARITY To E.coli YahF and some, to bacterial SucD. {ECO 0000305}. # SUBCELLULAR LOCATION FDRA_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # SUPFAM SSF52210 SSF52210; 2 # eggNOG COG0074 LUCA # eggNOG ENOG4107R1Q Bacteria BLAST swissprot:FDRA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FDRA_ECOLI BioCyc ECOL316407:JW0506-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0506-MONOMER BioCyc EcoCyc:G6287-MONOMER http://biocyc.org/getid?id=EcoCyc:G6287-MONOMER COG COG0074 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0074 DOI 10.1007/BF00290367 http://dx.doi.org/10.1007/BF00290367 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/15.17.6827 http://dx.doi.org/10.1093/nar/15.17.6827 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D42020 http://www.ebi.ac.uk/ena/data/view/D42020 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL X05968 http://www.ebi.ac.uk/ena/data/view/X05968 EchoBASE EB3180 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3180 EcoGene EG13399 http://www.ecogene.org/geneInfo.php?eg_id=EG13399 EnsemblBacteria AAC73620 http://www.ensemblgenomes.org/id/AAC73620 EnsemblBacteria AAC73620 http://www.ensemblgenomes.org/id/AAC73620 EnsemblBacteria BAE76296 http://www.ensemblgenomes.org/id/BAE76296 EnsemblBacteria BAE76296 http://www.ensemblgenomes.org/id/BAE76296 EnsemblBacteria BAE76296 http://www.ensemblgenomes.org/id/BAE76296 EnsemblBacteria b0518 http://www.ensemblgenomes.org/id/b0518 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0009361 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009361 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0004775 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004775 GO_function GO:0048037 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048037 GO_process GO:0006099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006099 GO_process GO:0006104 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006104 GO_process GO:0006105 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006105 GO_process GO:0009142 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009142 GO_process GO:0071973 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071973 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.261 http://www.cathdb.info/version/latest/superfamily/3.40.50.261 GeneID 946298 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946298 HOGENOM HOG000117378 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117378&db=HOGENOM6 IntAct Q47208 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q47208* InterPro IPR003781 http://www.ebi.ac.uk/interpro/entry/IPR003781 InterPro IPR005811 http://www.ebi.ac.uk/interpro/entry/IPR005811 InterPro IPR016102 http://www.ebi.ac.uk/interpro/entry/IPR016102 KEGG_Gene ecj:JW0506 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0506 KEGG_Gene eco:b0518 http://www.genome.jp/dbget-bin/www_bget?eco:b0518 KEGG_Orthology KO:K02381 http://www.genome.jp/dbget-bin/www_bget?KO:K02381 OMA SIMMGTP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SIMMGTP PDB 3DMY http://www.ebi.ac.uk/pdbe-srv/view/entry/3DMY PDBsum 3DMY http://www.ebi.ac.uk/pdbsum/3DMY PSORT swissprot:FDRA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FDRA_ECOLI PSORT-B swissprot:FDRA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FDRA_ECOLI PSORT2 swissprot:FDRA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FDRA_ECOLI Pfam PF00549 http://pfam.xfam.org/family/PF00549 Pfam PF02629 http://pfam.xfam.org/family/PF02629 Phobius swissprot:FDRA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FDRA_ECOLI ProteinModelPortal Q47208 http://www.proteinmodelportal.org/query/uniprot/Q47208 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3309887 http://www.ncbi.nlm.nih.gov/pubmed/3309887 PubMed 7500942 http://www.ncbi.nlm.nih.gov/pubmed/7500942 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415051 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415051 RefSeq WP_000580829 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000580829 SMR Q47208 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q47208 STRING 511145.b0518 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0518&targetmode=cogs STRING COG0074 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0074&targetmode=cogs SUPFAM SSF52210 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52210 UniProtKB FDRA_ECOLI http://www.uniprot.org/uniprot/FDRA_ECOLI UniProtKB-AC Q47208 http://www.uniprot.org/uniprot/Q47208 charge swissprot:FDRA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FDRA_ECOLI eggNOG COG0074 http://eggnogapi.embl.de/nog_data/html/tree/COG0074 eggNOG ENOG4107R1Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107R1Q epestfind swissprot:FDRA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FDRA_ECOLI garnier swissprot:FDRA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FDRA_ECOLI helixturnhelix swissprot:FDRA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FDRA_ECOLI hmoment swissprot:FDRA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FDRA_ECOLI iep swissprot:FDRA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FDRA_ECOLI inforesidue swissprot:FDRA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FDRA_ECOLI octanol swissprot:FDRA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FDRA_ECOLI pepcoil swissprot:FDRA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FDRA_ECOLI pepdigest swissprot:FDRA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FDRA_ECOLI pepinfo swissprot:FDRA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FDRA_ECOLI pepnet swissprot:FDRA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FDRA_ECOLI pepstats swissprot:FDRA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FDRA_ECOLI pepwheel swissprot:FDRA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FDRA_ECOLI pepwindow swissprot:FDRA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FDRA_ECOLI sigcleave swissprot:FDRA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FDRA_ECOLI ## Database ID URL or Descriptions # BRENDA 2.7.13 2026 # CATALYTIC ACTIVITY CUSS_ECOLI ATP + protein L-histidine = ADP + protein N- phospho-L-histidine. # CDD cd06225 HAMP # EcoGene EG13642 cusS # FUNCTION CUSS_ECOLI Member of the two-component regulatory system CusS/CusR. Copper ion sensor. Could also be a silver ion sensor. Activates CusR by phosphorylation. {ECO 0000269|PubMed 11004187, ECO 0000269|PubMed 11399769, ECO 0000269|PubMed 15522865}. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016020 membrane; NAS:EcoliWiki. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0000155 phosphorelay sensor kinase activity; IDA:EcoliWiki. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0009927 histidine phosphotransfer kinase activity; IDA:EcoCyc. # GO_process GO:0000160 phosphorelay signal transduction system; IDA:EcoCyc. # GO_process GO:0010628 positive regulation of gene expression; IMP:EcoCyc. # GO_process GO:0016310 phosphorylation; IDA:EcoliWiki. # GO_process GO:0046688 response to copper ion; IMP:EcoCyc. # GO_process GO:0071280 cellular response to copper ion; IMP:EcoCyc. # GO_process GO:0071292 cellular response to silver ion; IEP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005622 intracellular # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # Gene3D 1.10.287.130 -; 1. # Gene3D 3.30.565.10 -; 1. # IntAct P77485 2 # InterPro IPR003594 HATPase_C # InterPro IPR003660 HAMP_dom # InterPro IPR003661 HisK_dim/P # InterPro IPR004358 Sig_transdc_His_kin-like_C # InterPro IPR005467 His_kinase_dom # InterPro IPR006290 CztS_silS_copS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01001 Protein kinases # KEGG_Brite ko02022 M00452 CusS-CusR (copper tolerance) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # MISCELLANEOUS CUSS_ECOLI The cus system plays an important role in copper tolerance under anaerobic growth and, under extreme copper stress, in aerobic growth. # Organism CUSS_ECOLI Escherichia coli (strain K12) # PATRIC 32116308 VBIEscCol129921_0594 # PDB 5KU5 X-ray; 2.15 A; A/B/C/D=39-187 # PIR H64789 H64789 # PRINTS PR00344 BCTRLSENSOR # PROSITE PS50109 HIS_KIN # PROSITE PS50885 HAMP # PTM CUSS_ECOLI Autophosphorylated. # Pfam PF00512 HisKA # Pfam PF00672 HAMP # Pfam PF02518 HATPase_c # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CUSS_ECOLI Sensor kinase CusS # RefSeq NP_415102 NC_000913.3 # RefSeq WP_000253839 NZ_LN832404.1 # SIMILARITY Contains 1 HAMP domain. {ECO:0000255|PROSITE- ProRule PRU00102}. # SIMILARITY Contains 1 histidine kinase domain. {ECO:0000255|PROSITE-ProRule PRU00107}. # SMART SM00304 HAMP # SMART SM00387 HATPase_c # SMART SM00388 HisKA # SUBCELLULAR LOCATION CUSS_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF47384 SSF47384 # SUPFAM SSF55874 SSF55874 # TIGRFAMs TIGR01386 cztS_silS_copS # eggNOG COG0642 LUCA # eggNOG ENOG4105GR3 Bacteria BLAST swissprot:CUSS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CUSS_ECOLI BioCyc ECOL316407:JW5082-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5082-MONOMER BioCyc EcoCyc:G6318-MONOMER http://biocyc.org/getid?id=EcoCyc:G6318-MONOMER COG COG0642 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0642 DIP DIP-9349N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9349N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M104122200 http://dx.doi.org/10.1074/jbc.M104122200 DOI 10.1074/jbc.M410104200 http://dx.doi.org/10.1074/jbc.M410104200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.20.5864-5871.2000 http://dx.doi.org/10.1128/JB.182.20.5864-5871.2000 EC_number EC:2.7.13.3 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.13.3 EMBL AF245661 http://www.ebi.ac.uk/ena/data/view/AF245661 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 ENZYME 2.7.13.3 http://enzyme.expasy.org/EC/2.7.13.3 EchoBASE EB3406 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3406 EcoGene EG13642 http://www.ecogene.org/geneInfo.php?eg_id=EG13642 EnsemblBacteria AAC73671 http://www.ensemblgenomes.org/id/AAC73671 EnsemblBacteria AAC73671 http://www.ensemblgenomes.org/id/AAC73671 EnsemblBacteria BAA35204 http://www.ensemblgenomes.org/id/BAA35204 EnsemblBacteria BAA35204 http://www.ensemblgenomes.org/id/BAA35204 EnsemblBacteria BAA35204 http://www.ensemblgenomes.org/id/BAA35204 EnsemblBacteria b0570 http://www.ensemblgenomes.org/id/b0570 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0000155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000155 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0009927 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009927 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0010628 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010628 GO_process GO:0016310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016310 GO_process GO:0046688 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046688 GO_process GO:0071280 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071280 GO_process GO:0071292 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071292 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.10.287.130 http://www.cathdb.info/version/latest/superfamily/1.10.287.130 Gene3D 3.30.565.10 http://www.cathdb.info/version/latest/superfamily/3.30.565.10 GeneID 945978 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945978 HOGENOM HOG000126763 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126763&db=HOGENOM6 InParanoid P77485 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77485 IntAct P77485 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77485* IntEnz 2.7.13.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.13.3 InterPro IPR003594 http://www.ebi.ac.uk/interpro/entry/IPR003594 InterPro IPR003660 http://www.ebi.ac.uk/interpro/entry/IPR003660 InterPro IPR003661 http://www.ebi.ac.uk/interpro/entry/IPR003661 InterPro IPR004358 http://www.ebi.ac.uk/interpro/entry/IPR004358 InterPro IPR005467 http://www.ebi.ac.uk/interpro/entry/IPR005467 InterPro IPR006290 http://www.ebi.ac.uk/interpro/entry/IPR006290 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01001 http://www.genome.jp/dbget-bin/www_bget?ko01001 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW5082 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5082 KEGG_Gene eco:b0570 http://www.genome.jp/dbget-bin/www_bget?eco:b0570 KEGG_Orthology KO:K07644 http://www.genome.jp/dbget-bin/www_bget?KO:K07644 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA FVGDKRQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FVGDKRQ PDB 5KU5 http://www.ebi.ac.uk/pdbe-srv/view/entry/5KU5 PDBsum 5KU5 http://www.ebi.ac.uk/pdbsum/5KU5 PRINTS PR00344 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00344 PROSITE PS50109 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50109 PROSITE PS50885 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50885 PSORT swissprot:CUSS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CUSS_ECOLI PSORT-B swissprot:CUSS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CUSS_ECOLI PSORT2 swissprot:CUSS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CUSS_ECOLI Pfam PF00512 http://pfam.xfam.org/family/PF00512 Pfam PF00672 http://pfam.xfam.org/family/PF00672 Pfam PF02518 http://pfam.xfam.org/family/PF02518 Phobius swissprot:CUSS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CUSS_ECOLI PhylomeDB P77485 http://phylomedb.org/?seqid=P77485 ProteinModelPortal P77485 http://www.proteinmodelportal.org/query/uniprot/P77485 PubMed 11004187 http://www.ncbi.nlm.nih.gov/pubmed/11004187 PubMed 11283292 http://www.ncbi.nlm.nih.gov/pubmed/11283292 PubMed 11399769 http://www.ncbi.nlm.nih.gov/pubmed/11399769 PubMed 15522865 http://www.ncbi.nlm.nih.gov/pubmed/15522865 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415102 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415102 RefSeq WP_000253839 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000253839 SMART SM00304 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00304 SMART SM00387 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00387 SMART SM00388 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00388 SMR P77485 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77485 STRING 511145.b0570 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0570&targetmode=cogs STRING COG0642 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0642&targetmode=cogs SUPFAM SSF47384 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47384 SUPFAM SSF55874 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55874 TIGRFAMs TIGR01386 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01386 UniProtKB CUSS_ECOLI http://www.uniprot.org/uniprot/CUSS_ECOLI UniProtKB-AC P77485 http://www.uniprot.org/uniprot/P77485 charge swissprot:CUSS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CUSS_ECOLI eggNOG COG0642 http://eggnogapi.embl.de/nog_data/html/tree/COG0642 eggNOG ENOG4105GR3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105GR3 epestfind swissprot:CUSS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CUSS_ECOLI garnier swissprot:CUSS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CUSS_ECOLI helixturnhelix swissprot:CUSS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CUSS_ECOLI hmoment swissprot:CUSS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CUSS_ECOLI iep swissprot:CUSS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CUSS_ECOLI inforesidue swissprot:CUSS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CUSS_ECOLI octanol swissprot:CUSS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CUSS_ECOLI pepcoil swissprot:CUSS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CUSS_ECOLI pepdigest swissprot:CUSS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CUSS_ECOLI pepinfo swissprot:CUSS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CUSS_ECOLI pepnet swissprot:CUSS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CUSS_ECOLI pepstats swissprot:CUSS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CUSS_ECOLI pepwheel swissprot:CUSS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CUSS_ECOLI pepwindow swissprot:CUSS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CUSS_ECOLI sigcleave swissprot:CUSS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CUSS_ECOLI ## Database ID URL or Descriptions # BioGrid 4262522 8 # EcoGene EG12242 gadW # FUNCTION GADW_ECOLI Depending on the conditions (growth phase and medium), acts as a positive or negative regulator of gadA and gadBC. Repression occurs directly or via the repression of the expression of gadX. Activation occurs directly by the binding of GadW to the gadA and gadBC promoters. {ECO 0000269|PubMed 12446650, ECO 0000269|PubMed 12730179, ECO 0000269|PubMed 14617649}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0000987 core promoter proximal region sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IMP:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IMP:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.60 -; 1. # INDUCTION Expression can be repressed by GadX, depending on the conditions. {ECO:0000269|PubMed 14617649}. # IntAct P63201 6 # InterPro IPR009057 Homeodomain-like # InterPro IPR018060 HTH_AraC # InterPro IPR018062 HTH_AraC-typ_CS # InterPro IPR020449 Tscrpt_reg_HTH_AraC-type # MISCELLANEOUS GADW_ECOLI GadX and GadW are part of a complex system required for acid resistance via the regulation of gadA and gadBC. Many of the described circuits use mutants missing one of the network components. In the wild-type situation, however, many of the scenarios are not easily observed. # Organism GADW_ECOLI Escherichia coli (strain K12) # PATRIC 32122490 VBIEscCol129921_3623 # PIR S47735 S47735 # PRINTS PR00032 HTHARAC # PROSITE PS00041 HTH_ARAC_FAMILY_1 # PROSITE PS01124 HTH_ARAC_FAMILY_2 # Pfam PF12833 HTH_18 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GADW_ECOLI HTH-type transcriptional regulator GadW # RefSeq NP_417972 NC_000913.3 # RefSeq WP_000149999 NZ_LN832404.1 # SIMILARITY Contains 1 HTH araC/xylS-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00593}. # SMART SM00342 HTH_ARAC # SUBUNIT Homodimer. {ECO:0000269|PubMed 12446650}. # SUPFAM SSF46689 SSF46689 BLAST swissprot:GADW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GADW_ECOLI BioCyc ECOL316407:JW3483-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3483-MONOMER BioCyc EcoCyc:EG12242-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12242-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.24.7001-7012.2002 http://dx.doi.org/10.1128/JB.184.24.7001-7012.2002 DOI 10.1128/JB.185.10.3190-3201.2003 http://dx.doi.org/10.1128/JB.185.10.3190-3201.2003 DOI 10.1128/JB.185.23.6852-6859.2003 http://dx.doi.org/10.1128/JB.185.23.6852-6859.2003 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2153 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2153 EcoGene EG12242 http://www.ecogene.org/geneInfo.php?eg_id=EG12242 EnsemblBacteria AAC76540 http://www.ensemblgenomes.org/id/AAC76540 EnsemblBacteria AAC76540 http://www.ensemblgenomes.org/id/AAC76540 EnsemblBacteria BAE77779 http://www.ensemblgenomes.org/id/BAE77779 EnsemblBacteria BAE77779 http://www.ensemblgenomes.org/id/BAE77779 EnsemblBacteria BAE77779 http://www.ensemblgenomes.org/id/BAE77779 EnsemblBacteria b3515 http://www.ensemblgenomes.org/id/b3515 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000987 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000987 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 GeneID 948029 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948029 HOGENOM HOG000120708 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120708&db=HOGENOM6 InParanoid P63201 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P63201 IntAct P63201 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P63201* InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR018060 http://www.ebi.ac.uk/interpro/entry/IPR018060 InterPro IPR018062 http://www.ebi.ac.uk/interpro/entry/IPR018062 InterPro IPR020449 http://www.ebi.ac.uk/interpro/entry/IPR020449 KEGG_Gene ecj:JW3483 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3483 KEGG_Gene eco:b3515 http://www.genome.jp/dbget-bin/www_bget?eco:b3515 PRINTS PR00032 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00032 PROSITE PS00041 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00041 PROSITE PS01124 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01124 PSORT swissprot:GADW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GADW_ECOLI PSORT-B swissprot:GADW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GADW_ECOLI PSORT2 swissprot:GADW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GADW_ECOLI Pfam PF12833 http://pfam.xfam.org/family/PF12833 Phobius swissprot:GADW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GADW_ECOLI PhylomeDB P63201 http://phylomedb.org/?seqid=P63201 ProteinModelPortal P63201 http://www.proteinmodelportal.org/query/uniprot/P63201 PubMed 12446650 http://www.ncbi.nlm.nih.gov/pubmed/12446650 PubMed 12730179 http://www.ncbi.nlm.nih.gov/pubmed/12730179 PubMed 14617649 http://www.ncbi.nlm.nih.gov/pubmed/14617649 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417972 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417972 RefSeq WP_000149999 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000149999 SMART SM00342 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00342 SMR P63201 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P63201 STRING 511145.b3515 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3515&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 UniProtKB GADW_ECOLI http://www.uniprot.org/uniprot/GADW_ECOLI UniProtKB-AC P63201 http://www.uniprot.org/uniprot/P63201 charge swissprot:GADW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GADW_ECOLI epestfind swissprot:GADW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GADW_ECOLI garnier swissprot:GADW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GADW_ECOLI helixturnhelix swissprot:GADW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GADW_ECOLI hmoment swissprot:GADW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GADW_ECOLI iep swissprot:GADW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GADW_ECOLI inforesidue swissprot:GADW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GADW_ECOLI octanol swissprot:GADW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GADW_ECOLI pepcoil swissprot:GADW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GADW_ECOLI pepdigest swissprot:GADW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GADW_ECOLI pepinfo swissprot:GADW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GADW_ECOLI pepnet swissprot:GADW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GADW_ECOLI pepstats swissprot:GADW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GADW_ECOLI pepwheel swissprot:GADW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GADW_ECOLI pepwindow swissprot:GADW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GADW_ECOLI sigcleave swissprot:GADW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GADW_ECOLI ## Database ID URL or Descriptions # AltName CSRD_ECOLI Regulator of CsrB and CsrC decay CsrD # BioGrid 4261943 8 # CAUTION Although this protein contains both EAL and GGDEF domains it is unlikely to have either c-di-GMP phosphodiesterase or diguanylate cyclase activities as amino acids known to be important to these activities are not conserved. {ECO 0000305}. # CDD cd01948 EAL # CDD cd01949 GGDEF # DISRUPTION PHENOTYPE CSRD_ECOLI Dramatically stabilizes CsrB and CsrC RNAs, small RNAs that sequester the global carbon storage regulator CsrA; also decreased transcription of CsrB/C (PubMed 16980588). Decreased biofilm formation, decreased expression of AdrA, a probable diguanylate cyclase and of the curli regulator CsgD. Decreased expression of the curlin subunit CsgB, decreased curli expression at 28 degrees Celsius (PubMed 19332833). {ECO 0000269|PubMed 16980588, ECO 0000269|PubMed 17064377, ECO 0000269|PubMed 19332833}. # DOMAIN CSRD_ECOLI Removal of the transmembrane regions (residues 1-156) has no effect on csrB translation, however removal of either the HAMP- like region, EAL or GGDEF domains obviates the activity of CsrD. {ECO 0000269|PubMed 16980588}. # EcoGene EG10018 csrD # FUNCTION CSRD_ECOLI Serves as a specificity factor required for RNase E- mediated decay of the small global regulatory RNAs CsrB and CsrC, it is probably not a nuclease. Nor does its activity involve c-di- GMP, despite its domain composition. Positively modulates motility gene expression, is also required for curli expression. {ECO 0000269|PubMed 16980588, ECO 0000269|PubMed 17064377, ECO 0000269|PubMed 19332833}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0034661 ncRNA catabolic process; IMP:EcoCyc. # GO_process GO:0051252 regulation of RNA metabolic process; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0008150 biological_process # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # Gene3D 3.20.20.450 -; 1. # INDUCTION Expressed at low levels at both 28 and 37 degrees Celsius. {ECO:0000269|PubMed 19332833}. # InterPro IPR000160 GGDEF_dom # InterPro IPR001633 EAL_dom # InterPro IPR029787 Nucleotide_cyclase # InterPro IPR033423 GAPES4 # Organism CSRD_ECOLI Escherichia coli (strain K12) # PATRIC 32121930 VBIEscCol129921_3349 # PIR F65117 QQECE5 # PROSITE PS50883 EAL # PROSITE PS50887 GGDEF # Pfam PF00563 EAL # Pfam PF00990 GGDEF # Pfam PF17157 GAPES4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CSRD_ECOLI RNase E specificity factor CsrD # RefSeq NP_417718 NC_000913.3 # RefSeq WP_001241469 NZ_LN832404.1 # SIMILARITY Contains 1 EAL domain. {ECO:0000255|PROSITE- ProRule PRU00074}. # SIMILARITY Contains 1 GGDEF domain. {ECO:0000255|PROSITE- ProRule PRU00095}. # SMART SM00052 EAL # SMART SM00267 GGDEF # SUBCELLULAR LOCATION CSRD_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # SUPFAM SSF141868 SSF141868 # SUPFAM SSF55073 SSF55073 # TIGRFAMs TIGR00254 GGDEF # eggNOG ENOG41062P1 Bacteria # eggNOG ENOG410XSQH LUCA BLAST swissprot:CSRD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CSRD_ECOLI BioCyc ECOL316407:JW3221-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3221-MONOMER BioCyc EcoCyc:EG10018-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10018-MONOMER DIP DIP-12292N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12292N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1099/mic.0.024257-0 http://dx.doi.org/10.1099/mic.0.024257-0 DOI 10.1101/gad.1461606 http://dx.doi.org/10.1101/gad.1461606 DOI 10.1111/j.1574-6968.2006.00457.x http://dx.doi.org/10.1111/j.1574-6968.2006.00457.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M22055 http://www.ebi.ac.uk/ena/data/view/M22055 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB0018 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0018 EcoGene EG10018 http://www.ecogene.org/geneInfo.php?eg_id=EG10018 EnsemblBacteria AAC76284 http://www.ensemblgenomes.org/id/AAC76284 EnsemblBacteria AAC76284 http://www.ensemblgenomes.org/id/AAC76284 EnsemblBacteria BAE77294 http://www.ensemblgenomes.org/id/BAE77294 EnsemblBacteria BAE77294 http://www.ensemblgenomes.org/id/BAE77294 EnsemblBacteria BAE77294 http://www.ensemblgenomes.org/id/BAE77294 EnsemblBacteria b3252 http://www.ensemblgenomes.org/id/b3252 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0034661 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034661 GO_process GO:0051252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051252 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 Gene3D 3.20.20.450 http://www.cathdb.info/version/latest/superfamily/3.20.20.450 GeneID 947702 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947702 HOGENOM HOG000270419 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000270419&db=HOGENOM6 InParanoid P13518 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P13518 IntAct P13518 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P13518* InterPro IPR000160 http://www.ebi.ac.uk/interpro/entry/IPR000160 InterPro IPR001633 http://www.ebi.ac.uk/interpro/entry/IPR001633 InterPro IPR029787 http://www.ebi.ac.uk/interpro/entry/IPR029787 InterPro IPR033423 http://www.ebi.ac.uk/interpro/entry/IPR033423 KEGG_Gene ecj:JW3221 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3221 KEGG_Gene eco:b3252 http://www.genome.jp/dbget-bin/www_bget?eco:b3252 MINT MINT-1286606 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1286606 OMA TFVMRYP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TFVMRYP PROSITE PS50883 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50883 PROSITE PS50887 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50887 PSORT swissprot:CSRD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CSRD_ECOLI PSORT-B swissprot:CSRD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CSRD_ECOLI PSORT2 swissprot:CSRD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CSRD_ECOLI Pfam PF00563 http://pfam.xfam.org/family/PF00563 Pfam PF00990 http://pfam.xfam.org/family/PF00990 Pfam PF17157 http://pfam.xfam.org/family/PF17157 Phobius swissprot:CSRD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CSRD_ECOLI PhylomeDB P13518 http://phylomedb.org/?seqid=P13518 ProteinModelPortal P13518 http://www.proteinmodelportal.org/query/uniprot/P13518 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16980588 http://www.ncbi.nlm.nih.gov/pubmed/16980588 PubMed 17064377 http://www.ncbi.nlm.nih.gov/pubmed/17064377 PubMed 19332833 http://www.ncbi.nlm.nih.gov/pubmed/19332833 PubMed 3049542 http://www.ncbi.nlm.nih.gov/pubmed/3049542 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417718 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417718 RefSeq WP_001241469 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001241469 SMART SM00052 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00052 SMART SM00267 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00267 SMR P13518 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P13518 STRING 511145.b3252 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3252&targetmode=cogs SUPFAM SSF141868 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF141868 SUPFAM SSF55073 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55073 TIGRFAMs TIGR00254 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00254 UniProtKB CSRD_ECOLI http://www.uniprot.org/uniprot/CSRD_ECOLI UniProtKB-AC P13518 http://www.uniprot.org/uniprot/P13518 charge swissprot:CSRD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CSRD_ECOLI eggNOG ENOG41062P1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41062P1 eggNOG ENOG410XSQH http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XSQH epestfind swissprot:CSRD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CSRD_ECOLI garnier swissprot:CSRD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CSRD_ECOLI helixturnhelix swissprot:CSRD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CSRD_ECOLI hmoment swissprot:CSRD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CSRD_ECOLI iep swissprot:CSRD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CSRD_ECOLI inforesidue swissprot:CSRD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CSRD_ECOLI octanol swissprot:CSRD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CSRD_ECOLI pepcoil swissprot:CSRD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CSRD_ECOLI pepdigest swissprot:CSRD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CSRD_ECOLI pepinfo swissprot:CSRD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CSRD_ECOLI pepnet swissprot:CSRD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CSRD_ECOLI pepstats swissprot:CSRD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CSRD_ECOLI pepwheel swissprot:CSRD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CSRD_ECOLI pepwindow swissprot:CSRD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CSRD_ECOLI sigcleave swissprot:CSRD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CSRD_ECOLI ## Database ID URL or Descriptions # BioGrid 4259628 13 # CDD cd06174 MFS # EcoGene EG11687 setC # FUNCTION SETC_ECOLI Involved in the efflux of sugars. The physiological role may be the detoxification of non-metabolizable sugar analogs. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015542 sugar efflux transmembrane transporter activity; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # InterPro IPR004750 Sugar_efflux # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # KEGG_Brite ko02000 Transporters # Organism SETC_ECOLI Escherichia coli (strain K12) # PATRIC 32122807 VBIEscCol129921_3779 # PIR D65167 D65167 # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SETC_ECOLI Sugar efflux transporter C # RefSeq NP_418115 NC_000913.3 # RefSeq WP_001172878 NZ_LN832404.1 # SIMILARITY Belongs to the major facilitator superfamily. Set transporter family. {ECO 0000305}. # SUBCELLULAR LOCATION SETC_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.20 the major facilitator superfamily (mfs) # TIGRFAMs TIGR00899 2A0120 # eggNOG ENOG4105S8Q Bacteria # eggNOG ENOG410XTE9 LUCA BLAST swissprot:SETC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SETC_ECOLI BioCyc ECOL316407:JW3633-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3633-MONOMER BioCyc EcoCyc:B3659-MONOMER http://biocyc.org/getid?id=EcoCyc:B3659-MONOMER COG COG0477 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0477 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1999.01321.x http://dx.doi.org/10.1046/j.1365-2958.1999.01321.x DOI 10.1074/jbc.274.33.22977 http://dx.doi.org/10.1074/jbc.274.33.22977 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1638 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1638 EcoGene EG11687 http://www.ecogene.org/geneInfo.php?eg_id=EG11687 EnsemblBacteria AAC76682 http://www.ensemblgenomes.org/id/AAC76682 EnsemblBacteria AAC76682 http://www.ensemblgenomes.org/id/AAC76682 EnsemblBacteria BAE77635 http://www.ensemblgenomes.org/id/BAE77635 EnsemblBacteria BAE77635 http://www.ensemblgenomes.org/id/BAE77635 EnsemblBacteria BAE77635 http://www.ensemblgenomes.org/id/BAE77635 EnsemblBacteria b3659 http://www.ensemblgenomes.org/id/b3659 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015542 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015542 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GeneID 948177 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948177 HOGENOM HOG000281090 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000281090&db=HOGENOM6 InParanoid P31436 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31436 InterPro IPR004750 http://www.ebi.ac.uk/interpro/entry/IPR004750 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3633 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3633 KEGG_Gene eco:b3659 http://www.genome.jp/dbget-bin/www_bget?eco:b3659 KEGG_Orthology KO:K03291 http://www.genome.jp/dbget-bin/www_bget?KO:K03291 OMA EMGGRHA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EMGGRHA PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:SETC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SETC_ECOLI PSORT-B swissprot:SETC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SETC_ECOLI PSORT2 swissprot:SETC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SETC_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:SETC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SETC_ECOLI PhylomeDB P31436 http://phylomedb.org/?seqid=P31436 ProteinModelPortal P31436 http://www.proteinmodelportal.org/query/uniprot/P31436 PubMed 10209755 http://www.ncbi.nlm.nih.gov/pubmed/10209755 PubMed 10438463 http://www.ncbi.nlm.nih.gov/pubmed/10438463 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418115 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418115 RefSeq WP_001172878 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001172878 STRING 511145.b3659 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3659&targetmode=cogs STRING COG0477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0477&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.20 http://www.tcdb.org/search/result.php?tc=2.A.1.20 TIGRFAMs TIGR00899 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00899 UniProtKB SETC_ECOLI http://www.uniprot.org/uniprot/SETC_ECOLI UniProtKB-AC P31436 http://www.uniprot.org/uniprot/P31436 charge swissprot:SETC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SETC_ECOLI eggNOG ENOG4105S8Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105S8Q eggNOG ENOG410XTE9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XTE9 epestfind swissprot:SETC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SETC_ECOLI garnier swissprot:SETC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SETC_ECOLI helixturnhelix swissprot:SETC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SETC_ECOLI hmoment swissprot:SETC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SETC_ECOLI iep swissprot:SETC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SETC_ECOLI inforesidue swissprot:SETC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SETC_ECOLI octanol swissprot:SETC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SETC_ECOLI pepcoil swissprot:SETC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SETC_ECOLI pepdigest swissprot:SETC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SETC_ECOLI pepinfo swissprot:SETC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SETC_ECOLI pepnet swissprot:SETC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SETC_ECOLI pepstats swissprot:SETC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SETC_ECOLI pepwheel swissprot:SETC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SETC_ECOLI pepwindow swissprot:SETC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SETC_ECOLI sigcleave swissprot:SETC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SETC_ECOLI ## Database ID URL or Descriptions # AltName Glutamate permease {ECO:0000303|PubMed 2017136} # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: Vmax=5.2 nmol/min/mg enzyme {ECO 0000269|PubMed:2537813}; # BioGrid 4262574 14 # ENZYME REGULATION Inhibited by the uncoupler carbonylcyanide m- chlorophenylhydrazone (CCCP) and the ionophore monensin. {ECO:0000269|PubMed 2537813}. # EcoGene EG10406 gltS # FUNCTION GLTS_ECOLI Catalyzes the sodium-dependent, binding-protein- independent transport of glutamate. {ECO 0000255|HAMAP- Rule MF_02062, ECO 0000269|PubMed 2537813, ECO 0000269|PubMed 336628, ECO 0000269|PubMed 8596452}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GLTS_ECOLI GO 0015501 glutamate sodium symporter activity; IDA EcoCyc. # GO_function GO:0015293 symporter activity; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # HAMAP MF_02062 GltS # InterPro IPR004445 GltS # KEGG_Brite ko02000 Transporters # Organism GLTS_ECOLI Escherichia coli (strain K12) # PANTHER PTHR36178:SF1 PTHR36178:SF1 # PATRIC 32122793 VBIEscCol129921_3773 # PIR G65166 YOECNQ # Pfam PF03616 Glt_symporter # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Sodium/glutamate symporter {ECO:0000255|HAMAP-Rule MF_02062, ECO:0000305} # RefSeq NP_418110 NC_000913.3 # RefSeq WP_000468833 NZ_LN832404.1 # SIMILARITY GLTS_ECOLI Belongs to the glutamate Na(+) symporter (ESS) (TC 2.A.27) family. {ECO 0000255|HAMAP-Rule MF_02062, ECO 0000305}. # SUBCELLULAR LOCATION GLTS_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_02062, ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 17269795, ECO 0000269|PubMed 17662058, ECO 0000269|PubMed 2537813}; Multi-pass membrane protein {ECO 0000255|HAMAP-Rule MF_02062, ECO 0000269|PubMed 17269795, ECO 0000269|PubMed 17662058}. # TCDB 2.A.27.1:the glutamate na(+) symporter (ess) family # TIGRFAMs TIGR00210 gltS # eggNOG COG0786 LUCA # eggNOG ENOG4105D6U Bacteria BLAST swissprot:GLTS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLTS_ECOLI BioCyc ECOL316407:JW3628-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3628-MONOMER BioCyc EcoCyc:GLTS-MONOMER http://biocyc.org/getid?id=EcoCyc:GLTS-MONOMER BioCyc MetaCyc:GLTS-MONOMER http://biocyc.org/getid?id=MetaCyc:GLTS-MONOMER COG COG0786 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0786 DIP DIP-48023N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48023N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1007/BF00261677 http://dx.doi.org/10.1007/BF00261677 DOI 10.1016/0378-1119(92)90449-Y http://dx.doi.org/10.1016/0378-1119(92)90449-Y DOI 10.1021/bi062275i http://dx.doi.org/10.1021/bi062275i DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1995.mmi_18010123.x http://dx.doi.org/10.1111/j.1365-2958.1995.mmi_18010123.x DOI 10.1111/j.1574-6968.2007.00863.x http://dx.doi.org/10.1111/j.1574-6968.2007.00863.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D00626 http://www.ebi.ac.uk/ena/data/view/D00626 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M64367 http://www.ebi.ac.uk/ena/data/view/M64367 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X17499 http://www.ebi.ac.uk/ena/data/view/X17499 EchoBASE EB0401 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0401 EcoGene EG10406 http://www.ecogene.org/geneInfo.php?eg_id=EG10406 EnsemblBacteria AAC76677 http://www.ensemblgenomes.org/id/AAC76677 EnsemblBacteria AAC76677 http://www.ensemblgenomes.org/id/AAC76677 EnsemblBacteria BAE77640 http://www.ensemblgenomes.org/id/BAE77640 EnsemblBacteria BAE77640 http://www.ensemblgenomes.org/id/BAE77640 EnsemblBacteria BAE77640 http://www.ensemblgenomes.org/id/BAE77640 EnsemblBacteria b3653 http://www.ensemblgenomes.org/id/b3653 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015293 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293 GO_function GO:0015501 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015501 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GeneID 948166 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948166 HAMAP MF_02062 http://hamap.expasy.org/unirule/MF_02062 HOGENOM HOG000282013 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000282013&db=HOGENOM6 InParanoid P0AER8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AER8 IntAct P0AER8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AER8* InterPro IPR004445 http://www.ebi.ac.uk/interpro/entry/IPR004445 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3628 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3628 KEGG_Gene eco:b3653 http://www.genome.jp/dbget-bin/www_bget?eco:b3653 KEGG_Orthology KO:K03312 http://www.genome.jp/dbget-bin/www_bget?KO:K03312 OMA PTAMVNM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PTAMVNM PANTHER PTHR36178:SF1 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR36178:SF1 PSORT swissprot:GLTS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLTS_ECOLI PSORT-B swissprot:GLTS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLTS_ECOLI PSORT2 swissprot:GLTS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLTS_ECOLI Pfam PF03616 http://pfam.xfam.org/family/PF03616 Phobius swissprot:GLTS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLTS_ECOLI PhylomeDB P0AER8 http://phylomedb.org/?seqid=P0AER8 ProteinModelPortal P0AER8 http://www.proteinmodelportal.org/query/uniprot/P0AER8 PubMed 1544582 http://www.ncbi.nlm.nih.gov/pubmed/1544582 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17269795 http://www.ncbi.nlm.nih.gov/pubmed/17269795 PubMed 17662058 http://www.ncbi.nlm.nih.gov/pubmed/17662058 PubMed 2017136 http://www.ncbi.nlm.nih.gov/pubmed/2017136 PubMed 2254324 http://www.ncbi.nlm.nih.gov/pubmed/2254324 PubMed 2537813 http://www.ncbi.nlm.nih.gov/pubmed/2537813 PubMed 336628 http://www.ncbi.nlm.nih.gov/pubmed/336628 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 8596452 http://www.ncbi.nlm.nih.gov/pubmed/8596452 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418110 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418110 RefSeq WP_000468833 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000468833 STRING 511145.b3653 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3653&targetmode=cogs STRING COG0786 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0786&targetmode=cogs TCDB 2.A.27.1 http://www.tcdb.org/search/result.php?tc=2.A.27.1 TIGRFAMs TIGR00210 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00210 UniProtKB GLTS_ECOLI http://www.uniprot.org/uniprot/GLTS_ECOLI UniProtKB-AC P0AER8 http://www.uniprot.org/uniprot/P0AER8 charge swissprot:GLTS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLTS_ECOLI eggNOG COG0786 http://eggnogapi.embl.de/nog_data/html/tree/COG0786 eggNOG ENOG4105D6U http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D6U epestfind swissprot:GLTS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLTS_ECOLI garnier swissprot:GLTS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLTS_ECOLI helixturnhelix swissprot:GLTS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLTS_ECOLI hmoment swissprot:GLTS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLTS_ECOLI iep swissprot:GLTS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLTS_ECOLI inforesidue swissprot:GLTS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLTS_ECOLI octanol swissprot:GLTS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLTS_ECOLI pepcoil swissprot:GLTS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLTS_ECOLI pepdigest swissprot:GLTS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLTS_ECOLI pepinfo swissprot:GLTS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLTS_ECOLI pepnet swissprot:GLTS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLTS_ECOLI pepstats swissprot:GLTS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLTS_ECOLI pepwheel swissprot:GLTS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLTS_ECOLI pepwindow swissprot:GLTS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLTS_ECOLI sigcleave swissprot:GLTS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLTS_ECOLI ## Database ID URL or Descriptions # BioGrid 4260953 7 # EcoGene EG14275 ycgY # IntAct P76012 10 # Organism YCGY_ECOLI Escherichia coli (strain K12) # PATRIC 32117640 VBIEscCol129921_1242 # PIR A64866 A64866 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCGY_ECOLI Uncharacterized protein YcgY # RefSeq NP_415714 NC_000913.3 # RefSeq WP_000615067 NZ_LN832404.1 BLAST swissprot:YCGY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCGY_ECOLI BioCyc ECOL316407:JW1185-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1185-MONOMER BioCyc EcoCyc:G6625-MONOMER http://biocyc.org/getid?id=EcoCyc:G6625-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4023 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4023 EcoGene EG14275 http://www.ecogene.org/geneInfo.php?eg_id=EG14275 EnsemblBacteria AAC74280 http://www.ensemblgenomes.org/id/AAC74280 EnsemblBacteria AAC74280 http://www.ensemblgenomes.org/id/AAC74280 EnsemblBacteria BAE76391 http://www.ensemblgenomes.org/id/BAE76391 EnsemblBacteria BAE76391 http://www.ensemblgenomes.org/id/BAE76391 EnsemblBacteria BAE76391 http://www.ensemblgenomes.org/id/BAE76391 EnsemblBacteria b1196 http://www.ensemblgenomes.org/id/b1196 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945761 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945761 HOGENOM HOG000009434 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009434&db=HOGENOM6 IntAct P76012 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76012* KEGG_Gene ecj:JW1185 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1185 KEGG_Gene eco:b1196 http://www.genome.jp/dbget-bin/www_bget?eco:b1196 OMA QRRCKSP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QRRCKSP PSORT swissprot:YCGY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCGY_ECOLI PSORT-B swissprot:YCGY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCGY_ECOLI PSORT2 swissprot:YCGY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCGY_ECOLI Phobius swissprot:YCGY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCGY_ECOLI ProteinModelPortal P76012 http://www.proteinmodelportal.org/query/uniprot/P76012 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415714 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415714 RefSeq WP_000615067 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000615067 STRING 511145.b1196 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1196&targetmode=cogs UniProtKB YCGY_ECOLI http://www.uniprot.org/uniprot/YCGY_ECOLI UniProtKB-AC P76012 http://www.uniprot.org/uniprot/P76012 charge swissprot:YCGY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCGY_ECOLI epestfind swissprot:YCGY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCGY_ECOLI garnier swissprot:YCGY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCGY_ECOLI helixturnhelix swissprot:YCGY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCGY_ECOLI hmoment swissprot:YCGY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCGY_ECOLI iep swissprot:YCGY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCGY_ECOLI inforesidue swissprot:YCGY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCGY_ECOLI octanol swissprot:YCGY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCGY_ECOLI pepcoil swissprot:YCGY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCGY_ECOLI pepdigest swissprot:YCGY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCGY_ECOLI pepinfo swissprot:YCGY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCGY_ECOLI pepnet swissprot:YCGY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCGY_ECOLI pepstats swissprot:YCGY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCGY_ECOLI pepwheel swissprot:YCGY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCGY_ECOLI pepwindow swissprot:YCGY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCGY_ECOLI sigcleave swissprot:YCGY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCGY_ECOLI ## Database ID URL or Descriptions # EcoGene EG14016 ynhF # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016020 membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0071456 cellular response to hypoxia; IEP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006950 response to stress # INDUCTION YNHF_ECOLI Constitutively expressed (PubMed 19121005), repressed on shift from glucose minimal to glycerol minimal medium, induced in low oxygen (PubMed 19121005) (at protein level). {ECO 0000269|PubMed 19121005, ECO 0000269|PubMed 19734316}. # MASS SPECTROMETRY Mass=3023.740; Method=Electrospray; Range=1-29; Note=Includes N-formyl-Met.; Evidence={ECO:0000269|PubMed 21050835}; # Organism YNHF_ECOLI Escherichia coli (strain K12) # PATRIC 32118620 VBIEscCol129921_1730 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNHF_ECOLI Uncharacterized protein YnhF # RefSeq WP_000102278 NZ_LN832404.1 # RefSeq YP_001165321 NC_000913.3 # SUBCELLULAR LOCATION YNHF_ECOLI Cell inner membrane {ECO 0000305|PubMed 19121005, ECO 0000305|PubMed 21778229}; Single-pass membrane protein {ECO 0000269|PubMed 19121005, ECO 0000269|PubMed 21778229}. Note=May be able to insert into the membrane in both orientations. BLAST swissprot:YNHF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNHF_ECOLI BioCyc EcoCyc:MONOMER0-2822 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2822 DOI 10.1016/j.ab.2010.10.035 http://dx.doi.org/10.1016/j.ab.2010.10.035 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M111.245696 http://dx.doi.org/10.1074/jbc.M111.245696 DOI 10.1111/j.1365-2958.2008.06495.x http://dx.doi.org/10.1111/j.1365-2958.2008.06495.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00872-09 http://dx.doi.org/10.1128/JB.00872-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14016 http://www.ecogene.org/geneInfo.php?eg_id=EG14016 EnsemblBacteria ABP93447 http://www.ensemblgenomes.org/id/ABP93447 EnsemblBacteria ABP93447 http://www.ensemblgenomes.org/id/ABP93447 EnsemblBacteria b4602 http://www.ensemblgenomes.org/id/b4602 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0071456 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071456 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 5061505 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5061505 KEGG_Gene eco:b4602 http://www.genome.jp/dbget-bin/www_bget?eco:b4602 PSORT swissprot:YNHF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNHF_ECOLI PSORT-B swissprot:YNHF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNHF_ECOLI PSORT2 swissprot:YNHF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNHF_ECOLI Phobius swissprot:YNHF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNHF_ECOLI PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19121005 http://www.ncbi.nlm.nih.gov/pubmed/19121005 PubMed 19734316 http://www.ncbi.nlm.nih.gov/pubmed/19734316 PubMed 21050835 http://www.ncbi.nlm.nih.gov/pubmed/21050835 PubMed 21778229 http://www.ncbi.nlm.nih.gov/pubmed/21778229 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000102278 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000102278 RefSeq YP_001165321 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001165321 STRING 511145.b4602 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4602&targetmode=cogs UniProtKB YNHF_ECOLI http://www.uniprot.org/uniprot/YNHF_ECOLI UniProtKB-AC A5A618 http://www.uniprot.org/uniprot/A5A618 charge swissprot:YNHF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNHF_ECOLI epestfind swissprot:YNHF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNHF_ECOLI garnier swissprot:YNHF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNHF_ECOLI helixturnhelix swissprot:YNHF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNHF_ECOLI hmoment swissprot:YNHF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNHF_ECOLI iep swissprot:YNHF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNHF_ECOLI inforesidue swissprot:YNHF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNHF_ECOLI octanol swissprot:YNHF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNHF_ECOLI pepcoil swissprot:YNHF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNHF_ECOLI pepdigest swissprot:YNHF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNHF_ECOLI pepinfo swissprot:YNHF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNHF_ECOLI pepnet swissprot:YNHF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNHF_ECOLI pepstats swissprot:YNHF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNHF_ECOLI pepwheel swissprot:YNHF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNHF_ECOLI pepwindow swissprot:YNHF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNHF_ECOLI sigcleave swissprot:YNHF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNHF_ECOLI ## Database ID URL or Descriptions # BioGrid 4261862 12 # EcoGene EG13647 ybeQ # GO_process GO:0006979 response to oxidative stress; IMP:EcoCyc. # GOslim_process GO:0006950 response to stress # Gene3D 1.25.40.10 -; 2. # IntAct P77234 6 # InterPro IPR006597 Sel1-like # InterPro IPR011990 TPR-like_helical_dom # Organism YBEQ_ECOLI Escherichia coli (strain K12) # PATRIC 32116471 VBIEscCol129921_0675 # PIR B64799 B64799 # Pfam PF08238 Sel1; 8 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBEQ_ECOLI Uncharacterized protein YbeQ # RefSeq NP_415177 NC_000913.3 # RefSeq WP_000578178 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40845.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY To E.coli YbeT. {ECO 0000305}. # SMART SM00671 SEL1; 8 # eggNOG COG0790 LUCA # eggNOG ENOG4105EUU Bacteria BLAST swissprot:YBEQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBEQ_ECOLI BioCyc ECOL316407:JW5091-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5091-MONOMER BioCyc EcoCyc:G6351-MONOMER http://biocyc.org/getid?id=EcoCyc:G6351-MONOMER COG COG0790 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0790 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB3411 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3411 EcoGene EG13647 http://www.ecogene.org/geneInfo.php?eg_id=EG13647 EnsemblBacteria AAC73745 http://www.ensemblgenomes.org/id/AAC73745 EnsemblBacteria AAC73745 http://www.ensemblgenomes.org/id/AAC73745 EnsemblBacteria BAA35291 http://www.ensemblgenomes.org/id/BAA35291 EnsemblBacteria BAA35291 http://www.ensemblgenomes.org/id/BAA35291 EnsemblBacteria BAA35291 http://www.ensemblgenomes.org/id/BAA35291 EnsemblBacteria b0644 http://www.ensemblgenomes.org/id/b0644 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 1.25.40.10 http://www.cathdb.info/version/latest/superfamily/1.25.40.10 GeneID 945251 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945251 HOGENOM HOG000003584 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000003584&db=HOGENOM6 InParanoid P77234 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77234 IntAct P77234 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77234* InterPro IPR006597 http://www.ebi.ac.uk/interpro/entry/IPR006597 InterPro IPR011990 http://www.ebi.ac.uk/interpro/entry/IPR011990 KEGG_Gene ecj:JW5091 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5091 KEGG_Gene eco:b0644 http://www.genome.jp/dbget-bin/www_bget?eco:b0644 KEGG_Orthology KO:K07126 http://www.genome.jp/dbget-bin/www_bget?KO:K07126 OMA GYGTAQD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GYGTAQD PSORT swissprot:YBEQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBEQ_ECOLI PSORT-B swissprot:YBEQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBEQ_ECOLI PSORT2 swissprot:YBEQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBEQ_ECOLI Pfam PF08238 http://pfam.xfam.org/family/PF08238 Phobius swissprot:YBEQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBEQ_ECOLI PhylomeDB P77234 http://phylomedb.org/?seqid=P77234 ProteinModelPortal P77234 http://www.proteinmodelportal.org/query/uniprot/P77234 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415177 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415177 RefSeq WP_000578178 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000578178 SMART SM00671 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00671 SMR P77234 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77234 STRING 511145.b0644 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0644&targetmode=cogs STRING COG0790 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0790&targetmode=cogs UniProtKB YBEQ_ECOLI http://www.uniprot.org/uniprot/YBEQ_ECOLI UniProtKB-AC P77234 http://www.uniprot.org/uniprot/P77234 charge swissprot:YBEQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBEQ_ECOLI eggNOG COG0790 http://eggnogapi.embl.de/nog_data/html/tree/COG0790 eggNOG ENOG4105EUU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EUU epestfind swissprot:YBEQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBEQ_ECOLI garnier swissprot:YBEQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBEQ_ECOLI helixturnhelix swissprot:YBEQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBEQ_ECOLI hmoment swissprot:YBEQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBEQ_ECOLI iep swissprot:YBEQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBEQ_ECOLI inforesidue swissprot:YBEQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBEQ_ECOLI octanol swissprot:YBEQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBEQ_ECOLI pepcoil swissprot:YBEQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBEQ_ECOLI pepdigest swissprot:YBEQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBEQ_ECOLI pepinfo swissprot:YBEQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBEQ_ECOLI pepnet swissprot:YBEQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBEQ_ECOLI pepstats swissprot:YBEQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBEQ_ECOLI pepwheel swissprot:YBEQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBEQ_ECOLI pepwindow swissprot:YBEQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBEQ_ECOLI sigcleave swissprot:YBEQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBEQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4261612 15 # EcoGene EG13038 ygeH # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0000160 phosphorelay signal transduction system; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # Gene3D 1.25.40.10 -; 2. # IntAct P76639 2 # InterPro IPR001867 OmpR/PhoB-type_DNA-bd # InterPro IPR011990 TPR-like_helical_dom # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR013026 TPR-contain_dom # InterPro IPR016032 Sig_transdc_resp-reg_C-effctor # InterPro IPR019734 TPR_repeat # Organism YGEH_ECOLI Escherichia coli (strain K12) # PATRIC 32121120 VBIEscCol129921_2949 # PIR E65068 E65068 # PROSITE PS50005 TPR # PROSITE PS50293 TPR_REGION # PROSITE PS51755 OMPR_PHOB # Pfam PF00486 Trans_reg_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGEH_ECOLI Uncharacterized protein YgeH # RefSeq NP_417329 NC_000913.3 # RefSeq WP_000362702 NZ_LN832404.1 # SIMILARITY Contains 1 OmpR/PhoB-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU01091}. # SIMILARITY Contains 1 TPR repeat. {ECO:0000255|PROSITE- ProRule PRU00339}. # SMART SM00028 TPR # SMART SM00862 Trans_reg_C # SUPFAM SSF46894 SSF46894 # SUPFAM SSF48452 SSF48452 # eggNOG COG0457 LUCA # eggNOG COG3710 LUCA # eggNOG ENOG4108YAB Bacteria BLAST swissprot:YGEH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGEH_ECOLI BioCyc ECOL316407:JW2820-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2820-MONOMER BioCyc EcoCyc:G7472-MONOMER http://biocyc.org/getid?id=EcoCyc:G7472-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 EchoBASE EB2853 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2853 EcoGene EG13038 http://www.ecogene.org/geneInfo.php?eg_id=EG13038 EnsemblBacteria AAC75891 http://www.ensemblgenomes.org/id/AAC75891 EnsemblBacteria AAC75891 http://www.ensemblgenomes.org/id/AAC75891 EnsemblBacteria BAE76921 http://www.ensemblgenomes.org/id/BAE76921 EnsemblBacteria BAE76921 http://www.ensemblgenomes.org/id/BAE76921 EnsemblBacteria BAE76921 http://www.ensemblgenomes.org/id/BAE76921 EnsemblBacteria b2852 http://www.ensemblgenomes.org/id/b2852 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 1.25.40.10 http://www.cathdb.info/version/latest/superfamily/1.25.40.10 GeneID 946265 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946265 HOGENOM HOG000009549 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009549&db=HOGENOM6 IntAct P76639 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76639* InterPro IPR001867 http://www.ebi.ac.uk/interpro/entry/IPR001867 InterPro IPR011990 http://www.ebi.ac.uk/interpro/entry/IPR011990 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR013026 http://www.ebi.ac.uk/interpro/entry/IPR013026 InterPro IPR016032 http://www.ebi.ac.uk/interpro/entry/IPR016032 InterPro IPR019734 http://www.ebi.ac.uk/interpro/entry/IPR019734 KEGG_Gene ecj:JW2820 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2820 KEGG_Gene eco:b2852 http://www.genome.jp/dbget-bin/www_bget?eco:b2852 OMA NFHNERI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NFHNERI PROSITE PS50005 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50005 PROSITE PS50293 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50293 PROSITE PS51755 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51755 PSORT swissprot:YGEH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGEH_ECOLI PSORT-B swissprot:YGEH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGEH_ECOLI PSORT2 swissprot:YGEH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGEH_ECOLI Pfam PF00486 http://pfam.xfam.org/family/PF00486 Phobius swissprot:YGEH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGEH_ECOLI ProteinModelPortal P76639 http://www.proteinmodelportal.org/query/uniprot/P76639 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417329 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417329 RefSeq WP_000362702 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000362702 SMART SM00028 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00028 SMART SM00862 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00862 SMR P76639 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76639 STRING 511145.b2852 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2852&targetmode=cogs SUPFAM SSF46894 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46894 SUPFAM SSF48452 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48452 UniProtKB YGEH_ECOLI http://www.uniprot.org/uniprot/YGEH_ECOLI UniProtKB-AC P76639 http://www.uniprot.org/uniprot/P76639 charge swissprot:YGEH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGEH_ECOLI eggNOG COG0457 http://eggnogapi.embl.de/nog_data/html/tree/COG0457 eggNOG COG3710 http://eggnogapi.embl.de/nog_data/html/tree/COG3710 eggNOG ENOG4108YAB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108YAB epestfind swissprot:YGEH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGEH_ECOLI garnier swissprot:YGEH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGEH_ECOLI helixturnhelix swissprot:YGEH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGEH_ECOLI hmoment swissprot:YGEH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGEH_ECOLI iep swissprot:YGEH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGEH_ECOLI inforesidue swissprot:YGEH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGEH_ECOLI octanol swissprot:YGEH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGEH_ECOLI pepcoil swissprot:YGEH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGEH_ECOLI pepdigest swissprot:YGEH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGEH_ECOLI pepinfo swissprot:YGEH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGEH_ECOLI pepnet swissprot:YGEH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGEH_ECOLI pepstats swissprot:YGEH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGEH_ECOLI pepwheel swissprot:YGEH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGEH_ECOLI pepwindow swissprot:YGEH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGEH_ECOLI sigcleave swissprot:YGEH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGEH_ECOLI ## Database ID URL or Descriptions # AltName FADI_ECOLI ACSs # AltName FADI_ECOLI Acetyl-CoA acyltransferase # AltName FADI_ECOLI Acyl-CoA ligase # AltName FADI_ECOLI Beta-ketothiolase # AltName FADI_ECOLI Fatty acid oxidation complex subunit beta # BioGrid 4260534 173 # CATALYTIC ACTIVITY FADI_ECOLI Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA. # EcoGene EG14128 fadI # FUNCTION FADI_ECOLI Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. Strongly involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate and weakly involved in the aerobic degradation of long- chain fatty acids. {ECO 0000269|PubMed 12270828, ECO 0000269|PubMed 12535077}. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity; IDA:EcoliWiki. # GO_function GO:0003988 acetyl-CoA C-acyltransferase activity; IDA:EcoliWiki. # GO_function GO:0004300 enoyl-CoA hydratase activity; IDA:EcoliWiki. # GO_process GO:0033542 fatty acid beta-oxidation, unsaturated, even number; IMP:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.47.10 -; 4. # HAMAP MF_01618 FadI # INDUCTION FADI_ECOLI Unlike the aerobic pathway, the anaerobic pathway is not strongly repressed by FadR regulatory protein. # IntAct P76503 12 # InterPro IPR002155 Thiolase # InterPro IPR012806 Ac-CoA_C-AcTrfase_FadI # InterPro IPR016039 Thiolase-like # InterPro IPR020610 Thiolase_AS # InterPro IPR020613 Thiolase_CS # InterPro IPR020615 Thiolase_acyl_enz_int_AS # InterPro IPR020616 Thiolase_N # InterPro IPR020617 Thiolase_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00071 Fatty acid metabolism # KEGG_Pathway ko00280 Valine, leucine and isoleucine degradation # KEGG_Pathway ko00281 Geraniol degradation # KEGG_Pathway ko00362 Benzoate degradation # KEGG_Pathway ko00592 alpha-Linolenic acid metabolism # KEGG_Pathway ko00642 Ethylbenzene degradation # Organism FADI_ECOLI Escherichia coli (strain K12) # PATHWAY FADI_ECOLI Lipid metabolism; fatty acid beta-oxidation. # PATRIC 32120057 VBIEscCol129921_2438 # PIR D65007 D65007 # PIRSF PIRSF000429 Ac-CoA_Ac_transf # PROSITE PS00098 THIOLASE_1 # PROSITE PS00099 THIOLASE_3 # PROSITE PS00737 THIOLASE_2 # Pfam PF00108 Thiolase_N # Pfam PF02803 Thiolase_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FADI_ECOLI 3-ketoacyl-CoA thiolase # RefSeq NP_416844 NC_000913.3 # RefSeq WP_000531952 NZ_LN832404.1 # SIMILARITY Belongs to the thiolase family. {ECO 0000305}. # SUBCELLULAR LOCATION FADI_ECOLI Cytoplasm {ECO 0000250}. # SUBUNIT Heterotetramer of two alpha chains (FadJ) and two beta chains (FadI). {ECO 0000250}. # SUPFAM SSF53901 SSF53901; 2 # TIGRFAMs TIGR01930 AcCoA-C-Actrans # TIGRFAMs TIGR02446 FadI # eggNOG COG0183 LUCA # eggNOG ENOG4105CHU Bacteria BLAST swissprot:FADI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FADI_ECOLI BioCyc ECOL316407:JW2339-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2339-MONOMER BioCyc EcoCyc:G7213-MONOMER http://biocyc.org/getid?id=EcoCyc:G7213-MONOMER BioCyc MetaCyc:G7213-MONOMER http://biocyc.org/getid?id=MetaCyc:G7213-MONOMER COG COG0183 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0183 DIP DIP-11991N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11991N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2003.03341.x http://dx.doi.org/10.1046/j.1365-2958.2003.03341.x DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.20.5696-5705.2002 http://dx.doi.org/10.1128/JB.184.20.5696-5705.2002 EC_number EC:2.3.1.16 http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.16 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.3.1.16 http://enzyme.expasy.org/EC/2.3.1.16 EchoBASE EB3880 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3880 EcoGene EG14128 http://www.ecogene.org/geneInfo.php?eg_id=EG14128 EnsemblBacteria AAC75402 http://www.ensemblgenomes.org/id/AAC75402 EnsemblBacteria AAC75402 http://www.ensemblgenomes.org/id/AAC75402 EnsemblBacteria BAA16197 http://www.ensemblgenomes.org/id/BAA16197 EnsemblBacteria BAA16197 http://www.ensemblgenomes.org/id/BAA16197 EnsemblBacteria BAA16197 http://www.ensemblgenomes.org/id/BAA16197 EnsemblBacteria b2342 http://www.ensemblgenomes.org/id/b2342 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003857 GO_function GO:0003988 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003988 GO_function GO:0004300 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004300 GO_process GO:0033542 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033542 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.47.10 http://www.cathdb.info/version/latest/superfamily/3.40.47.10 GeneID 948823 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948823 HAMAP MF_01618 http://hamap.expasy.org/unirule/MF_01618 HOGENOM HOG000012240 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000012240&db=HOGENOM6 InParanoid P76503 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76503 IntAct P76503 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76503* IntEnz 2.3.1.16 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.16 InterPro IPR002155 http://www.ebi.ac.uk/interpro/entry/IPR002155 InterPro IPR012806 http://www.ebi.ac.uk/interpro/entry/IPR012806 InterPro IPR016039 http://www.ebi.ac.uk/interpro/entry/IPR016039 InterPro IPR020610 http://www.ebi.ac.uk/interpro/entry/IPR020610 InterPro IPR020613 http://www.ebi.ac.uk/interpro/entry/IPR020613 InterPro IPR020615 http://www.ebi.ac.uk/interpro/entry/IPR020615 InterPro IPR020616 http://www.ebi.ac.uk/interpro/entry/IPR020616 InterPro IPR020617 http://www.ebi.ac.uk/interpro/entry/IPR020617 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2339 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2339 KEGG_Gene eco:b2342 http://www.genome.jp/dbget-bin/www_bget?eco:b2342 KEGG_Orthology KO:K00632 http://www.genome.jp/dbget-bin/www_bget?KO:K00632 KEGG_Pathway ko00071 http://www.genome.jp/kegg-bin/show_pathway?ko00071 KEGG_Pathway ko00280 http://www.genome.jp/kegg-bin/show_pathway?ko00280 KEGG_Pathway ko00281 http://www.genome.jp/kegg-bin/show_pathway?ko00281 KEGG_Pathway ko00362 http://www.genome.jp/kegg-bin/show_pathway?ko00362 KEGG_Pathway ko00592 http://www.genome.jp/kegg-bin/show_pathway?ko00592 KEGG_Pathway ko00642 http://www.genome.jp/kegg-bin/show_pathway?ko00642 KEGG_Reaction rn:R00829 http://www.genome.jp/dbget-bin/www_bget?rn:R00829 KEGG_Reaction rn:R00927 http://www.genome.jp/dbget-bin/www_bget?rn:R00927 KEGG_Reaction rn:R01177 http://www.genome.jp/dbget-bin/www_bget?rn:R01177 KEGG_Reaction rn:R03778 http://www.genome.jp/dbget-bin/www_bget?rn:R03778 KEGG_Reaction rn:R03858 http://www.genome.jp/dbget-bin/www_bget?rn:R03858 KEGG_Reaction rn:R03991 http://www.genome.jp/dbget-bin/www_bget?rn:R03991 KEGG_Reaction rn:R04546 http://www.genome.jp/dbget-bin/www_bget?rn:R04546 KEGG_Reaction rn:R04742 http://www.genome.jp/dbget-bin/www_bget?rn:R04742 KEGG_Reaction rn:R04747 http://www.genome.jp/dbget-bin/www_bget?rn:R04747 KEGG_Reaction rn:R05506 http://www.genome.jp/dbget-bin/www_bget?rn:R05506 KEGG_Reaction rn:R07891 http://www.genome.jp/dbget-bin/www_bget?rn:R07891 KEGG_Reaction rn:R07895 http://www.genome.jp/dbget-bin/www_bget?rn:R07895 KEGG_Reaction rn:R07899 http://www.genome.jp/dbget-bin/www_bget?rn:R07899 KEGG_Reaction rn:R08091 http://www.genome.jp/dbget-bin/www_bget?rn:R08091 KEGG_Reaction rn:R08095 http://www.genome.jp/dbget-bin/www_bget?rn:R08095 OMA MTAFPEP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MTAFPEP PROSITE PS00098 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00098 PROSITE PS00099 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00099 PROSITE PS00737 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00737 PSORT swissprot:FADI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FADI_ECOLI PSORT-B swissprot:FADI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FADI_ECOLI PSORT2 swissprot:FADI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FADI_ECOLI Pfam PF00108 http://pfam.xfam.org/family/PF00108 Pfam PF02803 http://pfam.xfam.org/family/PF02803 Phobius swissprot:FADI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FADI_ECOLI PhylomeDB P76503 http://phylomedb.org/?seqid=P76503 ProteinModelPortal P76503 http://www.proteinmodelportal.org/query/uniprot/P76503 PubMed 12270828 http://www.ncbi.nlm.nih.gov/pubmed/12270828 PubMed 12535077 http://www.ncbi.nlm.nih.gov/pubmed/12535077 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416844 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416844 RefSeq WP_000531952 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000531952 SMR P76503 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76503 STRING 511145.b2342 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2342&targetmode=cogs STRING COG0183 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0183&targetmode=cogs SUPFAM SSF53901 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53901 TIGRFAMs TIGR01930 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01930 TIGRFAMs TIGR02446 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02446 UniProtKB FADI_ECOLI http://www.uniprot.org/uniprot/FADI_ECOLI UniProtKB-AC P76503 http://www.uniprot.org/uniprot/P76503 charge swissprot:FADI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FADI_ECOLI eggNOG COG0183 http://eggnogapi.embl.de/nog_data/html/tree/COG0183 eggNOG ENOG4105CHU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CHU epestfind swissprot:FADI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FADI_ECOLI garnier swissprot:FADI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FADI_ECOLI helixturnhelix swissprot:FADI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FADI_ECOLI hmoment swissprot:FADI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FADI_ECOLI iep swissprot:FADI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FADI_ECOLI inforesidue swissprot:FADI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FADI_ECOLI octanol swissprot:FADI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FADI_ECOLI pepcoil swissprot:FADI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FADI_ECOLI pepdigest swissprot:FADI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FADI_ECOLI pepinfo swissprot:FADI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FADI_ECOLI pepnet swissprot:FADI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FADI_ECOLI pepstats swissprot:FADI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FADI_ECOLI pepwheel swissprot:FADI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FADI_ECOLI pepwindow swissprot:FADI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FADI_ECOLI sigcleave swissprot:FADI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FADI_ECOLI ## Database ID URL or Descriptions # BioGrid 4259769 14 # EcoGene EG13153 yafP # GO_function GO:0008080 N-acetyltransferase activity; IEA:InterPro. # GO_process GO:0006281 DNA repair; IEA:UniProtKB-KW. # GO_process GO:0009432 SOS response; IEA:UniProtKB-KW. # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # Gene3D 3.40.630.30 -; 1. # INDUCTION By SOS response. A member of the dinB-yafNOP operon. {ECO:0000269|PubMed 12813093}. # IntAct Q47158 6 # InterPro IPR000182 GNAT_dom # InterPro IPR016181 Acyl_CoA_acyltransferase # KEGG_Brite ko01000 Enzymes # Organism YAFP_ECOLI Escherichia coli (strain K12) # PATRIC 32115583 VBIEscCol129921_0236 # PIR C64748 C64748 # PROSITE PS51186 GNAT # Pfam PF13673 Acetyltransf_10 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAFP_ECOLI Uncharacterized N-acetyltransferase YafP # RefSeq NP_414769 NC_000913.3 # RefSeq WP_001059892 NZ_LN832404.1 # SIMILARITY Belongs to the acetyltransferase family. {ECO 0000305}. # SIMILARITY Contains 1 N-acetyltransferase domain. {ECO:0000255|PROSITE-ProRule PRU00532}. # SUPFAM SSF55729 SSF55729 # eggNOG COG0454 LUCA # eggNOG ENOG4108HYG Bacteria BLAST swissprot:YAFP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAFP_ECOLI BioCyc ECOL316407:JW0224-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0224-MONOMER BioCyc EcoCyc:G6118-MONOMER http://biocyc.org/getid?id=EcoCyc:G6118-MONOMER COG COG0454 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0454 DOI 10.1016/0165-7992(95)90024-1 http://dx.doi.org/10.1016/0165-7992(95)90024-1 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.185.13.3972-3977.2003 http://dx.doi.org/10.1128/JB.185.13.3972-3977.2003 EC_number EC:2.3.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D38582 http://www.ebi.ac.uk/ena/data/view/D38582 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 ENZYME 2.3.1.- http://enzyme.expasy.org/EC/2.3.1.- EchoBASE EB2947 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2947 EcoGene EG13153 http://www.ecogene.org/geneInfo.php?eg_id=EG13153 EnsemblBacteria AAC73338 http://www.ensemblgenomes.org/id/AAC73338 EnsemblBacteria AAC73338 http://www.ensemblgenomes.org/id/AAC73338 EnsemblBacteria BAA77903 http://www.ensemblgenomes.org/id/BAA77903 EnsemblBacteria BAA77903 http://www.ensemblgenomes.org/id/BAA77903 EnsemblBacteria BAA77903 http://www.ensemblgenomes.org/id/BAA77903 EnsemblBacteria b0234 http://www.ensemblgenomes.org/id/b0234 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008080 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008080 GO_process GO:0006281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006281 GO_process GO:0009432 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009432 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.40.630.30 http://www.cathdb.info/version/latest/superfamily/3.40.630.30 GeneID 944912 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944912 HOGENOM HOG000279010 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000279010&db=HOGENOM6 InParanoid Q47158 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q47158 IntAct Q47158 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q47158* IntEnz 2.3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1 InterPro IPR000182 http://www.ebi.ac.uk/interpro/entry/IPR000182 InterPro IPR016181 http://www.ebi.ac.uk/interpro/entry/IPR016181 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0224 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0224 KEGG_Gene eco:b0234 http://www.genome.jp/dbget-bin/www_bget?eco:b0234 KEGG_Orthology KO:K03830 http://www.genome.jp/dbget-bin/www_bget?KO:K03830 OMA FFCHHEY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FFCHHEY PROSITE PS51186 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51186 PSORT swissprot:YAFP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAFP_ECOLI PSORT-B swissprot:YAFP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAFP_ECOLI PSORT2 swissprot:YAFP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAFP_ECOLI Pfam PF13673 http://pfam.xfam.org/family/PF13673 Phobius swissprot:YAFP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAFP_ECOLI PhylomeDB Q47158 http://phylomedb.org/?seqid=Q47158 ProteinModelPortal Q47158 http://www.proteinmodelportal.org/query/uniprot/Q47158 PubMed 12813093 http://www.ncbi.nlm.nih.gov/pubmed/12813093 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7596361 http://www.ncbi.nlm.nih.gov/pubmed/7596361 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414769 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414769 RefSeq WP_001059892 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001059892 SMR Q47158 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q47158 STRING 511145.b0234 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0234&targetmode=cogs STRING COG0454 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0454&targetmode=cogs SUPFAM SSF55729 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55729 UniProtKB YAFP_ECOLI http://www.uniprot.org/uniprot/YAFP_ECOLI UniProtKB-AC Q47158 http://www.uniprot.org/uniprot/Q47158 charge swissprot:YAFP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAFP_ECOLI eggNOG COG0454 http://eggnogapi.embl.de/nog_data/html/tree/COG0454 eggNOG ENOG4108HYG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108HYG epestfind swissprot:YAFP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAFP_ECOLI garnier swissprot:YAFP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAFP_ECOLI helixturnhelix swissprot:YAFP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAFP_ECOLI hmoment swissprot:YAFP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAFP_ECOLI iep swissprot:YAFP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAFP_ECOLI inforesidue swissprot:YAFP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAFP_ECOLI octanol swissprot:YAFP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAFP_ECOLI pepcoil swissprot:YAFP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAFP_ECOLI pepdigest swissprot:YAFP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAFP_ECOLI pepinfo swissprot:YAFP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAFP_ECOLI pepnet swissprot:YAFP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAFP_ECOLI pepstats swissprot:YAFP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAFP_ECOLI pepwheel swissprot:YAFP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAFP_ECOLI pepwindow swissprot:YAFP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAFP_ECOLI sigcleave swissprot:YAFP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAFP_ECOLI ## Database ID URL or Descriptions # BioGrid 4259555 9 # EcoGene EG11869 kdgT # FUNCTION KDGT_ECOLI The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IDA:EcoCyc. # GO_function KDGT_ECOLI GO 0005351 sugar proton symporter activity; IEA UniProtKB-HAMAP. # GO_function KDGT_ECOLI GO 0015649 2-keto-3-deoxygluconate proton symporter activity; IDA EcoCyc. # GO_process GO:0035429 gluconate transmembrane transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0055085 transmembrane transport # HAMAP MF_00070 KdgT # InterPro IPR004684 2keto-3dGluconate_permease # InterPro IPR018395 2keto-3dGluconate_permease_sub # Organism KDGT_ECOLI Escherichia coli (strain K12) # PATRIC 32123331 VBIEscCol129921_4026 # PIR S40853 S40853 # Pfam PF03812 KdgT # ProDom PD024513 2keto-3dGluconate_permease # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName KDGT_ECOLI 2-keto-3-deoxygluconate permease # RefSeq NP_418345 NC_000913.3 # RefSeq WP_001166063 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB03042.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the KdgT transporter family. {ECO 0000305}. # SUBCELLULAR LOCATION KDGT_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.10.1 the 2-keto-3-deoxygluconate transporter (kdgt) family # TIGRFAMs TIGR00793 kdgT # eggNOG ENOG4105CAX Bacteria # eggNOG ENOG410XNUJ LUCA BLAST swissprot:KDGT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:KDGT_ECOLI BioCyc ECOL316407:JW5560-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5560-MONOMER BioCyc EcoCyc:KDGT-MONOMER http://biocyc.org/getid?id=EcoCyc:KDGT-MONOMER BioCyc MetaCyc:KDGT-MONOMER http://biocyc.org/getid?id=MetaCyc:KDGT-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1815 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1815 EcoGene EG11869 http://www.ecogene.org/geneInfo.php?eg_id=EG11869 EnsemblBacteria AAC76891 http://www.ensemblgenomes.org/id/AAC76891 EnsemblBacteria AAC76891 http://www.ensemblgenomes.org/id/AAC76891 EnsemblBacteria BAE77400 http://www.ensemblgenomes.org/id/BAE77400 EnsemblBacteria BAE77400 http://www.ensemblgenomes.org/id/BAE77400 EnsemblBacteria BAE77400 http://www.ensemblgenomes.org/id/BAE77400 EnsemblBacteria b3909 http://www.ensemblgenomes.org/id/b3909 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005351 GO_function GO:0015649 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015649 GO_process GO:0035429 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035429 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 948407 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948407 HAMAP MF_00070 http://hamap.expasy.org/unirule/MF_00070 HOGENOM HOG000221851 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000221851&db=HOGENOM6 InParanoid P0A712 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A712 InterPro IPR004684 http://www.ebi.ac.uk/interpro/entry/IPR004684 InterPro IPR018395 http://www.ebi.ac.uk/interpro/entry/IPR018395 KEGG_Gene ecj:JW5560 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5560 KEGG_Gene eco:b3909 http://www.genome.jp/dbget-bin/www_bget?eco:b3909 KEGG_Orthology KO:K02526 http://www.genome.jp/dbget-bin/www_bget?KO:K02526 OMA ESGPFMT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ESGPFMT PSORT swissprot:KDGT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:KDGT_ECOLI PSORT-B swissprot:KDGT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:KDGT_ECOLI PSORT2 swissprot:KDGT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:KDGT_ECOLI Pfam PF03812 http://pfam.xfam.org/family/PF03812 Phobius swissprot:KDGT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:KDGT_ECOLI ProteinModelPortal P0A712 http://www.proteinmodelportal.org/query/uniprot/P0A712 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418345 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418345 RefSeq WP_001166063 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001166063 STRING 511145.b3909 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3909&targetmode=cogs TCDB 2.A.10.1 http://www.tcdb.org/search/result.php?tc=2.A.10.1 TIGRFAMs TIGR00793 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00793 UniProtKB KDGT_ECOLI http://www.uniprot.org/uniprot/KDGT_ECOLI UniProtKB-AC P0A712 http://www.uniprot.org/uniprot/P0A712 charge swissprot:KDGT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:KDGT_ECOLI eggNOG ENOG4105CAX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CAX eggNOG ENOG410XNUJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNUJ epestfind swissprot:KDGT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:KDGT_ECOLI garnier swissprot:KDGT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:KDGT_ECOLI helixturnhelix swissprot:KDGT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:KDGT_ECOLI hmoment swissprot:KDGT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:KDGT_ECOLI iep swissprot:KDGT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:KDGT_ECOLI inforesidue swissprot:KDGT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:KDGT_ECOLI octanol swissprot:KDGT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:KDGT_ECOLI pepcoil swissprot:KDGT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:KDGT_ECOLI pepdigest swissprot:KDGT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:KDGT_ECOLI pepinfo swissprot:KDGT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:KDGT_ECOLI pepnet swissprot:KDGT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:KDGT_ECOLI pepstats swissprot:KDGT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:KDGT_ECOLI pepwheel swissprot:KDGT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:KDGT_ECOLI pepwindow swissprot:KDGT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:KDGT_ECOLI sigcleave swissprot:KDGT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:KDGT_ECOLI ## Database ID URL or Descriptions # EcoGene EG14176 yffO # Organism YFFO_ECOLI Escherichia coli (strain K12) # PATRIC 32120273 VBIEscCol129921_2539 # PIR E65019 E65019 # Proteomes UP000000625 Chromosome # RecName YFFO_ECOLI Uncharacterized protein YffO # RefSeq NP_416941 NC_000913.3 # RefSeq WP_000398186 NZ_CP014272.1 BLAST swissprot:YFFO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFFO_ECOLI BioCyc EcoCyc:G7276-MONOMER http://biocyc.org/getid?id=EcoCyc:G7276-MONOMER DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3928 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3928 EcoGene EG14176 http://www.ecogene.org/geneInfo.php?eg_id=EG14176 EnsemblBacteria AAC75499 http://www.ensemblgenomes.org/id/AAC75499 EnsemblBacteria AAC75499 http://www.ensemblgenomes.org/id/AAC75499 EnsemblBacteria b2446 http://www.ensemblgenomes.org/id/b2446 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946929 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946929 KEGG_Gene eco:b2446 http://www.genome.jp/dbget-bin/www_bget?eco:b2446 PSORT swissprot:YFFO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFFO_ECOLI PSORT-B swissprot:YFFO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFFO_ECOLI PSORT2 swissprot:YFFO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFFO_ECOLI Phobius swissprot:YFFO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFFO_ECOLI ProteinModelPortal P76546 http://www.proteinmodelportal.org/query/uniprot/P76546 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416941 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416941 RefSeq WP_000398186 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000398186 SMR P76546 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76546 STRING 511145.b2446 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2446&targetmode=cogs UniProtKB YFFO_ECOLI http://www.uniprot.org/uniprot/YFFO_ECOLI UniProtKB-AC P76546 http://www.uniprot.org/uniprot/P76546 charge swissprot:YFFO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFFO_ECOLI epestfind swissprot:YFFO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFFO_ECOLI garnier swissprot:YFFO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFFO_ECOLI helixturnhelix swissprot:YFFO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFFO_ECOLI hmoment swissprot:YFFO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFFO_ECOLI iep swissprot:YFFO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFFO_ECOLI inforesidue swissprot:YFFO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFFO_ECOLI octanol swissprot:YFFO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFFO_ECOLI pepcoil swissprot:YFFO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFFO_ECOLI pepdigest swissprot:YFFO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFFO_ECOLI pepinfo swissprot:YFFO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFFO_ECOLI pepnet swissprot:YFFO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFFO_ECOLI pepstats swissprot:YFFO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFFO_ECOLI pepwheel swissprot:YFFO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFFO_ECOLI pepwindow swissprot:YFFO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFFO_ECOLI sigcleave swissprot:YFFO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFFO_ECOLI ## Database ID URL or Descriptions # AltName Pyruvate, water dikinase regulatory protein {ECO:0000255|HAMAP-Rule MF_01062} # BioGrid 4260288 13 # CATALYTIC ACTIVITY PSRP_ECOLI ADP + [pyruvate, water dikinase] = AMP + [pyruvate, water dikinase] phosphate. {ECO 0000255|HAMAP- Rule MF_01062, ECO 0000269|PubMed 20044937}. # CATALYTIC ACTIVITY PSRP_ECOLI [Pyruvate, water dikinase] phosphate + phosphate = [pyruvate, water dikinase] + diphosphate. {ECO 0000255|HAMAP-Rule MF_01062, ECO 0000269|PubMed 20044937}. # EcoGene EG11132 ppsR # FUNCTION PSRP_ECOLI Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation. {ECO 0000255|HAMAP-Rule MF_01062, ECO 0000269|PubMed 20044937}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004674 protein serine/threonine kinase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0005524 ATP binding; IEA:InterPro. # GO_function GO:0016776 phosphotransferase activity, phosphate group as acceptor; IEA:UniProtKB-HAMAP. # GO_function GO:0030234 enzyme regulator activity; IDA:EcoCyc. # GO_function GO:0043531 ADP binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006470 protein dephosphorylation; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0030234 enzyme regulator activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # HAMAP MF_01062 PSRP # INTERACTION PSRP_ECOLI P33643 rluD; NbExp=2; IntAct=EBI-548302, EBI-558026; # IntAct P0A8A4 13 # InterPro IPR005177 Kinase-pyrophosphorylase # InterPro IPR026530 PSRP # Organism PSRP_ECOLI Escherichia coli (strain K12) # PATRIC 32118712 VBIEscCol129921_1774 # PIR G64928 QQECAD # Pfam PF03618 Kinase-PPPase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Phosphoenolpyruvate synthase regulatory protein {ECO:0000255|HAMAP-Rule MF_01062} # RefSeq NP_416218 NC_000913.3 # RefSeq WP_000368046 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=M69116; Type=Frameshift; Positions=64, 90; Evidence={ECO 0000305}; # SIMILARITY Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily. {ECO:0000255|HAMAP- Rule MF_01062}. # SUBUNIT Homotetramer. {ECO:0000269|PubMed 20044937}. # eggNOG COG1806 LUCA # eggNOG ENOG4105CF9 Bacteria BLAST swissprot:PSRP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PSRP_ECOLI BioCyc ECOL316407:JW1693-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1693-MONOMER BioCyc EcoCyc:EG11132-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11132-MONOMER COG COG1806 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1806 DIP DIP-47885N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47885N DOI 10.1016/0022-2836(81)90334-X http://dx.doi.org/10.1016/0022-2836(81)90334-X DOI 10.1016/0378-1119(91)90544-L http://dx.doi.org/10.1016/0378-1119(91)90544-L DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1186/1471-2091-11-1 http://dx.doi.org/10.1186/1471-2091-11-1 EC_number EC:2.7.11.33 {ECO:0000255|HAMAP-Rule:MF_01062} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.11.33 {ECO:0000255|HAMAP-Rule:MF_01062} EC_number EC:2.7.4.28 {ECO:0000255|HAMAP-Rule:MF_01062} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.4.28 {ECO:0000255|HAMAP-Rule:MF_01062} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M38266 http://www.ebi.ac.uk/ena/data/view/M38266 EMBL M69116 http://www.ebi.ac.uk/ena/data/view/M69116 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00261 http://www.ebi.ac.uk/ena/data/view/V00261 ENZYME 2.7.11.33 {ECO:0000255|HAMAP-Rule:MF_01062} http://enzyme.expasy.org/EC/2.7.11.33 {ECO:0000255|HAMAP-Rule:MF_01062} ENZYME 2.7.4.28 {ECO:0000255|HAMAP-Rule:MF_01062} http://enzyme.expasy.org/EC/2.7.4.28 {ECO:0000255|HAMAP-Rule:MF_01062} EchoBASE EB1122 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1122 EcoGene EG11132 http://www.ecogene.org/geneInfo.php?eg_id=EG11132 EnsemblBacteria AAC74773 http://www.ensemblgenomes.org/id/AAC74773 EnsemblBacteria AAC74773 http://www.ensemblgenomes.org/id/AAC74773 EnsemblBacteria BAA15472 http://www.ensemblgenomes.org/id/BAA15472 EnsemblBacteria BAA15472 http://www.ensemblgenomes.org/id/BAA15472 EnsemblBacteria BAA15472 http://www.ensemblgenomes.org/id/BAA15472 EnsemblBacteria b1703 http://www.ensemblgenomes.org/id/b1703 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004674 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016776 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016776 GO_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 GO_function GO:0043531 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043531 GO_process GO:0006470 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006470 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GeneID 946207 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946207 HAMAP MF_01062 http://hamap.expasy.org/unirule/MF_01062 HOGENOM HOG000218053 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218053&db=HOGENOM6 InParanoid P0A8A4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8A4 IntAct P0A8A4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8A4* IntEnz 2.7.11.33 {ECO:0000255|HAMAP-Rule:MF_01062} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.11.33 {ECO:0000255|HAMAP-Rule:MF_01062} IntEnz 2.7.4.28 {ECO:0000255|HAMAP-Rule:MF_01062} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.4.28 {ECO:0000255|HAMAP-Rule:MF_01062} InterPro IPR005177 http://www.ebi.ac.uk/interpro/entry/IPR005177 InterPro IPR026530 http://www.ebi.ac.uk/interpro/entry/IPR026530 KEGG_Gene ecj:JW1693 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1693 KEGG_Gene eco:b1703 http://www.genome.jp/dbget-bin/www_bget?eco:b1703 KEGG_Orthology KO:K09773 http://www.genome.jp/dbget-bin/www_bget?KO:K09773 MINT MINT-1236315 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1236315 OMA YAQCEFE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YAQCEFE PSORT swissprot:PSRP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PSRP_ECOLI PSORT-B swissprot:PSRP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PSRP_ECOLI PSORT2 swissprot:PSRP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PSRP_ECOLI Pfam PF03618 http://pfam.xfam.org/family/PF03618 Phobius swissprot:PSRP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PSRP_ECOLI PhylomeDB P0A8A4 http://phylomedb.org/?seqid=P0A8A4 ProteinModelPortal P0A8A4 http://www.proteinmodelportal.org/query/uniprot/P0A8A4 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1677907 http://www.ncbi.nlm.nih.gov/pubmed/1677907 PubMed 20044937 http://www.ncbi.nlm.nih.gov/pubmed/20044937 PubMed 6167722 http://www.ncbi.nlm.nih.gov/pubmed/6167722 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416218 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416218 RefSeq WP_000368046 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000368046 SMR P0A8A4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8A4 STRING 511145.b1703 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1703&targetmode=cogs STRING COG1806 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1806&targetmode=cogs UniProtKB PSRP_ECOLI http://www.uniprot.org/uniprot/PSRP_ECOLI UniProtKB-AC P0A8A4 http://www.uniprot.org/uniprot/P0A8A4 charge swissprot:PSRP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PSRP_ECOLI eggNOG COG1806 http://eggnogapi.embl.de/nog_data/html/tree/COG1806 eggNOG ENOG4105CF9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CF9 epestfind swissprot:PSRP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PSRP_ECOLI garnier swissprot:PSRP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PSRP_ECOLI helixturnhelix swissprot:PSRP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PSRP_ECOLI hmoment swissprot:PSRP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PSRP_ECOLI iep swissprot:PSRP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PSRP_ECOLI inforesidue swissprot:PSRP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PSRP_ECOLI octanol swissprot:PSRP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PSRP_ECOLI pepcoil swissprot:PSRP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PSRP_ECOLI pepdigest swissprot:PSRP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PSRP_ECOLI pepinfo swissprot:PSRP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PSRP_ECOLI pepnet swissprot:PSRP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PSRP_ECOLI pepstats swissprot:PSRP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PSRP_ECOLI pepwheel swissprot:PSRP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PSRP_ECOLI pepwindow swissprot:PSRP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PSRP_ECOLI sigcleave swissprot:PSRP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PSRP_ECOLI ## Database ID URL or Descriptions # BioGrid 4262352 14 # COFACTOR YGGW_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000250, ECO 0000305}; Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. {ECO 0000250, ECO 0000305}; # EcoGene EG12983 yggW # FUNCTION YGGW_ECOLI Involved in the biosynthesis of porphyrin-containing compound. {ECO 0000250}. # GO_component GO:0005737 cytoplasm; ISS:UniProtKB. # GO_function GO:0004109 coproporphyrinogen oxidase activity; IEA:InterPro. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; ISS:UniProtKB. # GO_process GO:0006779 porphyrin-containing compound biosynthetic process; ISS:UniProtKB. # GO_process GO:0006782 protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.80.30.20 -; 1. # IntAct P52062 15 # InterPro IPR004559 Coprogen_oxidase_HemN-rel # InterPro IPR006638 Elp3/MiaB/NifB # InterPro IPR007197 rSAM # InterPro IPR010723 HemN_C # InterPro IPR023404 rSAM_horseshoe # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00860 Porphyrin and chlorophyll metabolism # Organism YGGW_ECOLI Escherichia coli (strain K12) # PATHWAY YGGW_ECOLI Porphyrin-containing compound metabolism; protoporphyrin- IX biosynthesis. # PATRIC 32121322 VBIEscCol129921_3049 # PIR B65081 B65081 # Pfam PF04055 Radical_SAM # Pfam PF06969 HemN_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGGW_ECOLI Oxygen-independent coproporphyrinogen-III oxidase-like protein YggW # RefSeq NP_417430 NC_000913.3 # RefSeq WP_000239943 NZ_LN832404.1 # SIMILARITY Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemN-like subfamily. {ECO 0000305}. # SMART SM00729 Elp3 # TIGRFAMs TIGR00539 hemN_rel # eggNOG COG0635 LUCA # eggNOG ENOG4105CSA Bacteria BLAST swissprot:YGGW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGGW_ECOLI BioCyc ECOL316407:JW2922-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2922-MONOMER BioCyc EcoCyc:G7531-MONOMER http://biocyc.org/getid?id=EcoCyc:G7531-MONOMER COG COG0635 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0635 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.3.99.- http://www.genome.jp/dbget-bin/www_bget?EC:1.3.99.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 ENZYME 1.3.99.- http://enzyme.expasy.org/EC/1.3.99.- EchoBASE EB2808 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2808 EcoGene EG12983 http://www.ecogene.org/geneInfo.php?eg_id=EG12983 EnsemblBacteria AAC75992 http://www.ensemblgenomes.org/id/AAC75992 EnsemblBacteria AAC75992 http://www.ensemblgenomes.org/id/AAC75992 EnsemblBacteria BAE77018 http://www.ensemblgenomes.org/id/BAE77018 EnsemblBacteria BAE77018 http://www.ensemblgenomes.org/id/BAE77018 EnsemblBacteria BAE77018 http://www.ensemblgenomes.org/id/BAE77018 EnsemblBacteria b2955 http://www.ensemblgenomes.org/id/b2955 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004109 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004109 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0006779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006779 GO_process GO:0006782 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006782 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.80.30.20 http://www.cathdb.info/version/latest/superfamily/3.80.30.20 GeneID 947446 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947446 HOGENOM HOG000015379 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000015379&db=HOGENOM6 InParanoid P52062 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P52062 IntAct P52062 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P52062* IntEnz 1.3.99 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.3.99 InterPro IPR004559 http://www.ebi.ac.uk/interpro/entry/IPR004559 InterPro IPR006638 http://www.ebi.ac.uk/interpro/entry/IPR006638 InterPro IPR007197 http://www.ebi.ac.uk/interpro/entry/IPR007197 InterPro IPR010723 http://www.ebi.ac.uk/interpro/entry/IPR010723 InterPro IPR023404 http://www.ebi.ac.uk/interpro/entry/IPR023404 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2922 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2922 KEGG_Gene eco:b2955 http://www.genome.jp/dbget-bin/www_bget?eco:b2955 KEGG_Orthology KO:K02495 http://www.genome.jp/dbget-bin/www_bget?KO:K02495 KEGG_Pathway ko00860 http://www.genome.jp/kegg-bin/show_pathway?ko00860 KEGG_Reaction rn:R06895 http://www.genome.jp/dbget-bin/www_bget?rn:R06895 MINT MINT-1261070 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1261070 OMA RTAKTRH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RTAKTRH PSORT swissprot:YGGW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGGW_ECOLI PSORT-B swissprot:YGGW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGGW_ECOLI PSORT2 swissprot:YGGW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGGW_ECOLI Pfam PF04055 http://pfam.xfam.org/family/PF04055 Pfam PF06969 http://pfam.xfam.org/family/PF06969 Phobius swissprot:YGGW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGGW_ECOLI PhylomeDB P52062 http://phylomedb.org/?seqid=P52062 ProteinModelPortal P52062 http://www.proteinmodelportal.org/query/uniprot/P52062 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417430 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417430 RefSeq WP_000239943 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000239943 SMART SM00729 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00729 SMR P52062 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P52062 STRING 511145.b2955 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2955&targetmode=cogs STRING COG0635 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0635&targetmode=cogs TIGRFAMs TIGR00539 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00539 UniProtKB YGGW_ECOLI http://www.uniprot.org/uniprot/YGGW_ECOLI UniProtKB-AC P52062 http://www.uniprot.org/uniprot/P52062 charge swissprot:YGGW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGGW_ECOLI eggNOG COG0635 http://eggnogapi.embl.de/nog_data/html/tree/COG0635 eggNOG ENOG4105CSA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CSA epestfind swissprot:YGGW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGGW_ECOLI garnier swissprot:YGGW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGGW_ECOLI helixturnhelix swissprot:YGGW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGGW_ECOLI hmoment swissprot:YGGW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGGW_ECOLI iep swissprot:YGGW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGGW_ECOLI inforesidue swissprot:YGGW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGGW_ECOLI octanol swissprot:YGGW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGGW_ECOLI pepcoil swissprot:YGGW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGGW_ECOLI pepdigest swissprot:YGGW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGGW_ECOLI pepinfo swissprot:YGGW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGGW_ECOLI pepnet swissprot:YGGW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGGW_ECOLI pepstats swissprot:YGGW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGGW_ECOLI pepwheel swissprot:YGGW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGGW_ECOLI pepwindow swissprot:YGGW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGGW_ECOLI sigcleave swissprot:YGGW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGGW_ECOLI ## Database ID URL or Descriptions # AltName AMPD_ECOLI N-acetylmuramoyl-L-alanine amidase # BioGrid 4261895 176 # CATALYTIC ACTIVITY AMPD_ECOLI Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. # CDD cd06583 PGRP # COFACTOR AMPD_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000250}; Note=Zn(2+) is required for amidase activity. {ECO 0000250}; # EcoGene EG10041 ampD # FUNCTION AMPD_ECOLI Involved in both cell wall peptidoglycans recycling and beta-lactamase induction. Specifically cleaves the amide bond between the lactyl group of N-acetylmuramic acid and the alpha- amino group of the L-alanine in degradation products containing an anhydro N-acetylmuramyl moiety (By similarity). {ECO 0000250}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0008745 N-acetylmuramoyl-L-alanine amidase activity; IBA:GO_Central. # GO_function GO:0009392 N-acetyl-anhydromuramoyl-L-alanine amidase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0009253 peptidoglycan catabolic process; IBA:GO_Central. # GO_process GO:0009254 peptidoglycan turnover; IMP:EcoCyc. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 3.40.80.10 -; 1. # INDUCTION AMPD_ECOLI Inactivation of AmpD results in AmpR-dependent hyperinduction and AmpD affects beta-lactam susceptibility in the absence of cloned C.freundii amp genes suggesting a linkage between AmpD and peptidoglycan synthesis. # InterPro IPR002502 Amidase_domain # Organism AMPD_ECOLI Escherichia coli (strain K12) # PATRIC 32115321 VBIEscCol129921_0112 # PIR S05569 S05569 # Pfam PF01510 Amidase_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AMPD_ECOLI 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD # RefSeq NP_414652 NC_000913.3 # RefSeq WP_000923721 NZ_LN832404.1 # SIMILARITY Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. {ECO 0000305}. # SMART SM00644 Ami_2 # SUBCELLULAR LOCATION AMPD_ECOLI Cytoplasm. # SUPFAM SSF55846 SSF55846 # eggNOG COG3023 LUCA # eggNOG ENOG4108VBV Bacteria BLAST swissprot:AMPD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AMPD_ECOLI BioCyc ECOL316407:JW0106-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0106-MONOMER BioCyc EcoCyc:EG10041-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10041-MONOMER BioCyc MetaCyc:EG10041-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10041-MONOMER COG COG3023 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3023 DOI 10.1016/0378-1119(94)90851-6 http://dx.doi.org/10.1016/0378-1119(94)90851-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1989.tb00259.x http://dx.doi.org/10.1111/j.1365-2958.1989.tb00259.x DOI 10.1111/j.1365-2958.1989.tb00262.x http://dx.doi.org/10.1111/j.1365-2958.1989.tb00262.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.5.1.28 http://www.genome.jp/dbget-bin/www_bget?EC:3.5.1.28 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L28105 http://www.ebi.ac.uk/ena/data/view/L28105 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X15237 http://www.ebi.ac.uk/ena/data/view/X15237 ENZYME 3.5.1.28 http://enzyme.expasy.org/EC/3.5.1.28 EchoBASE EB0039 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0039 EcoGene EG10041 http://www.ecogene.org/geneInfo.php?eg_id=EG10041 EnsemblBacteria AAC73221 http://www.ensemblgenomes.org/id/AAC73221 EnsemblBacteria AAC73221 http://www.ensemblgenomes.org/id/AAC73221 EnsemblBacteria BAB96679 http://www.ensemblgenomes.org/id/BAB96679 EnsemblBacteria BAB96679 http://www.ensemblgenomes.org/id/BAB96679 EnsemblBacteria BAB96679 http://www.ensemblgenomes.org/id/BAB96679 EnsemblBacteria b0110 http://www.ensemblgenomes.org/id/b0110 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0008745 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008745 GO_function GO:0009392 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009392 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0009253 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009253 GO_process GO:0009254 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009254 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 3.40.80.10 http://www.cathdb.info/version/latest/superfamily/3.40.80.10 GeneID 948877 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948877 HOGENOM HOG000255963 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000255963&db=HOGENOM6 InParanoid P13016 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P13016 IntEnz 3.5.1.28 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.1.28 InterPro IPR002502 http://www.ebi.ac.uk/interpro/entry/IPR002502 KEGG_Gene ecj:JW0106 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0106 KEGG_Gene eco:b0110 http://www.genome.jp/dbget-bin/www_bget?eco:b0110 KEGG_Orthology KO:K03806 http://www.genome.jp/dbget-bin/www_bget?KO:K03806 OMA NAHPFFA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NAHPFFA PSORT swissprot:AMPD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AMPD_ECOLI PSORT-B swissprot:AMPD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AMPD_ECOLI PSORT2 swissprot:AMPD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AMPD_ECOLI Pfam PF01510 http://pfam.xfam.org/family/PF01510 Phobius swissprot:AMPD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AMPD_ECOLI PhylomeDB P13016 http://phylomedb.org/?seqid=P13016 ProteinModelPortal P13016 http://www.proteinmodelportal.org/query/uniprot/P13016 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2607970 http://www.ncbi.nlm.nih.gov/pubmed/2607970 PubMed 2691840 http://www.ncbi.nlm.nih.gov/pubmed/2691840 PubMed 7959070 http://www.ncbi.nlm.nih.gov/pubmed/7959070 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414652 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414652 RefSeq WP_000923721 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000923721 SMART SM00644 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00644 STRING 511145.b0110 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0110&targetmode=cogs STRING COG3023 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3023&targetmode=cogs SUPFAM SSF55846 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55846 UniProtKB AMPD_ECOLI http://www.uniprot.org/uniprot/AMPD_ECOLI UniProtKB-AC P13016 http://www.uniprot.org/uniprot/P13016 charge swissprot:AMPD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AMPD_ECOLI eggNOG COG3023 http://eggnogapi.embl.de/nog_data/html/tree/COG3023 eggNOG ENOG4108VBV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108VBV epestfind swissprot:AMPD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AMPD_ECOLI garnier swissprot:AMPD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AMPD_ECOLI helixturnhelix swissprot:AMPD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AMPD_ECOLI hmoment swissprot:AMPD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AMPD_ECOLI iep swissprot:AMPD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AMPD_ECOLI inforesidue swissprot:AMPD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AMPD_ECOLI octanol swissprot:AMPD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AMPD_ECOLI pepcoil swissprot:AMPD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AMPD_ECOLI pepdigest swissprot:AMPD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AMPD_ECOLI pepinfo swissprot:AMPD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AMPD_ECOLI pepnet swissprot:AMPD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AMPD_ECOLI pepstats swissprot:AMPD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AMPD_ECOLI pepwheel swissprot:AMPD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AMPD_ECOLI pepwindow swissprot:AMPD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AMPD_ECOLI sigcleave swissprot:AMPD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AMPD_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES PLSB_ECOLI Kinetic parameters KM=49 uM for glycerol-3-phosphate {ECO 0000269|PubMed 10231527, ECO 0000269|PubMed 7026564}; Vmax=13.1 nmol/min/mg enzyme with glycerol-3-phosphate as substrate {ECO 0000269|PubMed 10231527, ECO 0000269|PubMed 7026564}; pH dependence Optimum pH is 8.5. {ECO 0000269|PubMed 10231527, ECO 0000269|PubMed 7026564}; # BioGrid 4261720 245 # CATALYTIC ACTIVITY PLSB_ECOLI Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1- acyl-sn-glycerol 3-phosphate. # DOMAIN PLSB_ECOLI The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. # EcoGene EG10740 plsB # FUNCTION PLSB_ECOLI Catalyzes the transfer of an acyl group from acyl-ACP to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme can utilize either acyl-CoA or acyl-ACP as the fatty acyl donor. {ECO 0000269|PubMed 17645809, ECO 0000269|PubMed 6997313}. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoliWiki. # GO_function GO:0004366 glycerol-3-phosphate O-acyltransferase activity; IMP:EcoliWiki. # GO_process GO:0006631 fatty acid metabolic process; IMP:EcoliWiki. # GO_process GO:0008654 phospholipid biosynthetic process; IMP:EcoliWiki. # GO_process GO:0016024 CDP-diacylglycerol biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # HAMAP MF_00393 Glyc3P_acyltrans # INTERACTION PLSB_ECOLI P0A6A8 acpP; NbExp=3; IntAct=EBI-542961, EBI-542566; # IntAct P0A7A7 36 # InterPro IPR002123 Plipid/glycerol_acylTrfase # InterPro IPR022284 GPAT/DHAPAT # InterPro IPR028354 GPAT_PlsB # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01004 Lipid biosynthesis proteins # KEGG_Pathway ko00561 Glycerolipid metabolism # KEGG_Pathway ko00564 Glycerophospholipid metabolism # Organism PLSB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR12563 PTHR12563; 2 # PATHWAY Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate step 1/3. # PATRIC 32123619 VBIEscCol129921_4158 # PIR A00565 XUECAG # PIRSF PIRSF000437 GPAT_DHAPAT # PIRSF PIRSF500064 GPAT # Pfam PF01553 Acyltransferase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PLSB_ECOLI Glycerol-3-phosphate acyltransferase # RefSeq NP_418465 NC_000913.3 # RefSeq WP_000017354 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAC43135.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the GPAT/DAPAT family. {ECO 0000305}. # SMART SM00563 PlsC # SUBCELLULAR LOCATION PLSB_ECOLI Cell inner membrane {ECO 0000269|PubMed 16294310, ECO 0000269|PubMed 4943977}; Peripheral membrane protein {ECO 0000269|PubMed 16294310, ECO 0000269|PubMed 4943977}; Cytoplasmic side {ECO 0000269|PubMed 16294310, ECO 0000269|PubMed 4943977}. # SUBUNIT Interacts with ACP, YbgC and PssA, forming altogether a complex at the inner membrane. {ECO:0000269|PubMed 16294310}. # TIGRFAMs TIGR03703 plsB # UniPathway UPA00557 UER00612 # eggNOG COG2937 LUCA # eggNOG ENOG4105E55 Bacteria BLAST swissprot:PLSB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PLSB_ECOLI BioCyc ECOL316407:JW4001-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4001-MONOMER BioCyc EcoCyc:GLYCEROL-3-P-ACYLTRANSFER-MONOMER http://biocyc.org/getid?id=EcoCyc:GLYCEROL-3-P-ACYLTRANSFER-MONOMER BioCyc MetaCyc:GLYCEROL-3-P-ACYLTRANSFER-MONOMER http://biocyc.org/getid?id=MetaCyc:GLYCEROL-3-P-ACYLTRANSFER-MONOMER COG COG2937 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2937 DIP DIP-29380N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-29380N DOI 10.1002/pmic.200500115 http://dx.doi.org/10.1002/pmic.200500115 DOI 10.1016/0005-2736(71)90145-3 http://dx.doi.org/10.1016/0005-2736(71)90145-3 DOI 10.1021/bi982805d http://dx.doi.org/10.1021/bi982805d DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1186/1471-2180-7-69 http://dx.doi.org/10.1186/1471-2180-7-69 EC_number EC:2.3.1.15 http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.15 EMBL AF106625 http://www.ebi.ac.uk/ena/data/view/AF106625 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K00127 http://www.ebi.ac.uk/ena/data/view/K00127 EMBL M93136 http://www.ebi.ac.uk/ena/data/view/M93136 EMBL M93413 http://www.ebi.ac.uk/ena/data/view/M93413 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.3.1.15 http://enzyme.expasy.org/EC/2.3.1.15 EchoBASE EB0733 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0733 EcoGene EG10740 http://www.ecogene.org/geneInfo.php?eg_id=EG10740 EnsemblBacteria AAC77011 http://www.ensemblgenomes.org/id/AAC77011 EnsemblBacteria AAC77011 http://www.ensemblgenomes.org/id/AAC77011 EnsemblBacteria BAE78043 http://www.ensemblgenomes.org/id/BAE78043 EnsemblBacteria BAE78043 http://www.ensemblgenomes.org/id/BAE78043 EnsemblBacteria BAE78043 http://www.ensemblgenomes.org/id/BAE78043 EnsemblBacteria b4041 http://www.ensemblgenomes.org/id/b4041 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0004366 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004366 GO_process GO:0006631 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006631 GO_process GO:0008654 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008654 GO_process GO:0016024 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016024 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 948541 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948541 HAMAP MF_00393 http://hamap.expasy.org/unirule/MF_00393 HOGENOM HOG000218231 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218231&db=HOGENOM6 InParanoid P0A7A7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7A7 IntAct P0A7A7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7A7* IntEnz 2.3.1.15 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.15 InterPro IPR002123 http://www.ebi.ac.uk/interpro/entry/IPR002123 InterPro IPR022284 http://www.ebi.ac.uk/interpro/entry/IPR022284 InterPro IPR028354 http://www.ebi.ac.uk/interpro/entry/IPR028354 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01004 http://www.genome.jp/dbget-bin/www_bget?ko01004 KEGG_Gene ecj:JW4001 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4001 KEGG_Gene eco:b4041 http://www.genome.jp/dbget-bin/www_bget?eco:b4041 KEGG_Orthology KO:K00631 http://www.genome.jp/dbget-bin/www_bget?KO:K00631 KEGG_Pathway ko00561 http://www.genome.jp/kegg-bin/show_pathway?ko00561 KEGG_Pathway ko00564 http://www.genome.jp/kegg-bin/show_pathway?ko00564 KEGG_Reaction rn:R00851 http://www.genome.jp/dbget-bin/www_bget?rn:R00851 KEGG_Reaction rn:R09380 http://www.genome.jp/dbget-bin/www_bget?rn:R09380 MINT MINT-1221841 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1221841 OMA EVIYVPC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EVIYVPC PANTHER PTHR12563 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12563 PSORT swissprot:PLSB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PLSB_ECOLI PSORT-B swissprot:PLSB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PLSB_ECOLI PSORT2 swissprot:PLSB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PLSB_ECOLI Pfam PF01553 http://pfam.xfam.org/family/PF01553 Phobius swissprot:PLSB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PLSB_ECOLI PhylomeDB P0A7A7 http://phylomedb.org/?seqid=P0A7A7 ProteinModelPortal P0A7A7 http://www.proteinmodelportal.org/query/uniprot/P0A7A7 PubMed 10074094 http://www.ncbi.nlm.nih.gov/pubmed/10074094 PubMed 10231527 http://www.ncbi.nlm.nih.gov/pubmed/10231527 PubMed 16294310 http://www.ncbi.nlm.nih.gov/pubmed/16294310 PubMed 1644758 http://www.ncbi.nlm.nih.gov/pubmed/1644758 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17645809 http://www.ncbi.nlm.nih.gov/pubmed/17645809 PubMed 4943977 http://www.ncbi.nlm.nih.gov/pubmed/4943977 PubMed 6251087 http://www.ncbi.nlm.nih.gov/pubmed/6251087 PubMed 6309817 http://www.ncbi.nlm.nih.gov/pubmed/6309817 PubMed 6350296 http://www.ncbi.nlm.nih.gov/pubmed/6350296 PubMed 6997313 http://www.ncbi.nlm.nih.gov/pubmed/6997313 PubMed 7026564 http://www.ncbi.nlm.nih.gov/pubmed/7026564 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9515909 http://www.ncbi.nlm.nih.gov/pubmed/9515909 RefSeq NP_418465 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418465 RefSeq WP_000017354 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000017354 SMART SM00563 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00563 SMR P0A7A7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7A7 STRING 511145.b4041 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4041&targetmode=cogs STRING COG2937 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2937&targetmode=cogs TIGRFAMs TIGR03703 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03703 UniProtKB PLSB_ECOLI http://www.uniprot.org/uniprot/PLSB_ECOLI UniProtKB-AC P0A7A7 http://www.uniprot.org/uniprot/P0A7A7 charge swissprot:PLSB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PLSB_ECOLI eggNOG COG2937 http://eggnogapi.embl.de/nog_data/html/tree/COG2937 eggNOG ENOG4105E55 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E55 epestfind swissprot:PLSB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PLSB_ECOLI garnier swissprot:PLSB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PLSB_ECOLI helixturnhelix swissprot:PLSB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PLSB_ECOLI hmoment swissprot:PLSB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PLSB_ECOLI iep swissprot:PLSB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PLSB_ECOLI inforesidue swissprot:PLSB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PLSB_ECOLI octanol swissprot:PLSB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PLSB_ECOLI pepcoil swissprot:PLSB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PLSB_ECOLI pepdigest swissprot:PLSB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PLSB_ECOLI pepinfo swissprot:PLSB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PLSB_ECOLI pepnet swissprot:PLSB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PLSB_ECOLI pepstats swissprot:PLSB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PLSB_ECOLI pepwheel swissprot:PLSB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PLSB_ECOLI pepwindow swissprot:PLSB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PLSB_ECOLI sigcleave swissprot:PLSB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PLSB_ECOLI ## Database ID URL or Descriptions # AltName INTZ_ECOLI Putative prophage CPZ-55 integrase # EcoGene EG14172 intZ # FUNCTION INTZ_ECOLI Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome. # GO_function GO:0008979 prophage integrase activity; IBA:GO_Central. # GO_function GO:0043565 sequence-specific DNA binding; IBA:GO_Central. # GO_process GO:0006310 DNA recombination; IEA:UniProtKB-KW. # GO_process GO:0032359 provirus excision; IBA:GO_Central. # GO_process GO:0046718 viral entry into host cell; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0044403 symbiosis, encompassing mutualism through parasitism # Gene3D 1.10.150.130 -; 1. # Gene3D 1.10.443.10 -; 1. # InterPro IPR002104 Integrase_catalytic # InterPro IPR011010 DNA_brk_join_enz # InterPro IPR013762 Integrase-like_cat # InterPro IPR023109 Integrase_recombinase_N # InterPro IPR025166 DUF4102 # Organism INTZ_ECOLI Escherichia coli (strain K12) # PATRIC 32120269 VBIEscCol129921_2537 # PIR A65019 A65019 # Pfam PF00589 Phage_integrase # Pfam PF13356 DUF4102 # Proteomes UP000000625 Chromosome # RecName Prophage integrase IntZ {ECO 0000305} # RefSeq NP_416937 NC_000913.3 # RefSeq WP_000047773 NZ_CP014272.1 # SIMILARITY Belongs to the 'phage' integrase family. {ECO 0000305}. # SUPFAM SSF56349 SSF56349 # eggNOG COG0582 LUCA # eggNOG ENOG4105DFP Bacteria BLAST swissprot:INTZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INTZ_ECOLI BioCyc EcoCyc:G7272-MONOMER http://biocyc.org/getid?id=EcoCyc:G7272-MONOMER DIP DIP-10042N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10042N DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3924 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3924 EcoGene EG14172 http://www.ecogene.org/geneInfo.php?eg_id=EG14172 EnsemblBacteria AAC75495 http://www.ensemblgenomes.org/id/AAC75495 EnsemblBacteria AAC75495 http://www.ensemblgenomes.org/id/AAC75495 EnsemblBacteria b2442 http://www.ensemblgenomes.org/id/b2442 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008979 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0032359 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032359 GO_process GO:0046718 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046718 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0044403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403 Gene3D 1.10.150.130 http://www.cathdb.info/version/latest/superfamily/1.10.150.130 Gene3D 1.10.443.10 http://www.cathdb.info/version/latest/superfamily/1.10.443.10 GeneID 946923 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946923 HOGENOM HOG000263105 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000263105&db=HOGENOM6 InParanoid P76542 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76542 InterPro IPR002104 http://www.ebi.ac.uk/interpro/entry/IPR002104 InterPro IPR011010 http://www.ebi.ac.uk/interpro/entry/IPR011010 InterPro IPR013762 http://www.ebi.ac.uk/interpro/entry/IPR013762 InterPro IPR023109 http://www.ebi.ac.uk/interpro/entry/IPR023109 InterPro IPR025166 http://www.ebi.ac.uk/interpro/entry/IPR025166 KEGG_Gene eco:b2442 http://www.genome.jp/dbget-bin/www_bget?eco:b2442 OMA ACRINEV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ACRINEV PSORT swissprot:INTZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INTZ_ECOLI PSORT-B swissprot:INTZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INTZ_ECOLI PSORT2 swissprot:INTZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INTZ_ECOLI Pfam PF00589 http://pfam.xfam.org/family/PF00589 Pfam PF13356 http://pfam.xfam.org/family/PF13356 Phobius swissprot:INTZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INTZ_ECOLI PhylomeDB P76542 http://phylomedb.org/?seqid=P76542 ProteinModelPortal P76542 http://www.proteinmodelportal.org/query/uniprot/P76542 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416937 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416937 RefSeq WP_000047773 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000047773 SMR P76542 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76542 STRING 511145.b2442 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2442&targetmode=cogs SUPFAM SSF56349 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56349 UniProtKB INTZ_ECOLI http://www.uniprot.org/uniprot/INTZ_ECOLI UniProtKB-AC P76542 http://www.uniprot.org/uniprot/P76542 charge swissprot:INTZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INTZ_ECOLI eggNOG COG0582 http://eggnogapi.embl.de/nog_data/html/tree/COG0582 eggNOG ENOG4105DFP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DFP epestfind swissprot:INTZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INTZ_ECOLI garnier swissprot:INTZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INTZ_ECOLI helixturnhelix swissprot:INTZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INTZ_ECOLI hmoment swissprot:INTZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INTZ_ECOLI iep swissprot:INTZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INTZ_ECOLI inforesidue swissprot:INTZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INTZ_ECOLI octanol swissprot:INTZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INTZ_ECOLI pepcoil swissprot:INTZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INTZ_ECOLI pepdigest swissprot:INTZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INTZ_ECOLI pepinfo swissprot:INTZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INTZ_ECOLI pepnet swissprot:INTZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INTZ_ECOLI pepstats swissprot:INTZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INTZ_ECOLI pepwheel swissprot:INTZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INTZ_ECOLI pepwindow swissprot:INTZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INTZ_ECOLI sigcleave swissprot:INTZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INTZ_ECOLI ## Database ID URL or Descriptions # AltName NADB_ECOLI Quinolinate synthase B # BRENDA 1.4.3.16 2026 # BioGrid 4263282 13 # CATALYTIC ACTIVITY NADB_ECOLI L-aspartate + O(2) = iminosuccinate + H(2)O(2). # COFACTOR Name=FAD; Xref=ChEBI:CHEBI 57692; # DrugBank DB03147 Flavin adenine dinucleotide # EcoGene EG10631 nadB # FUNCTION NADB_ECOLI Catalyzes the oxidation of L-aspartate to iminoaspartate. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008734 L-aspartate oxidase activity; IDA:EcoCyc. # GO_function GO:0009055 electron carrier activity; IBA:GO_Central. # GO_function GO:0050660 flavin adenine dinucleotide binding; IDA:EcoCyc. # GO_function NADB_ECOLI GO 0044318 L-aspartate fumarate oxidoreductase activity; IDA EcoCyc. # GO_process GO:0009061 anaerobic respiration; IBA:GO_Central. # GO_process GO:0034628 'de novo' NAD biosynthetic process from aspartate; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 1.20.58.100 -; 1. # Gene3D 3.50.50.60 -; 2. # Gene3D 3.90.700.10 -; 1. # IntAct P10902 7 # InterPro IPR003953 FAD-binding_2 # InterPro IPR005288 NadB # InterPro IPR015939 Fum_Rdtase/Succ_DH_flav-like_C # InterPro IPR023753 FAD/NAD-binding_dom # InterPro IPR027477 Succ_DH/fumarate_Rdtase_cat # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00250 Alanine, aspartate and glutamate metabolism # KEGG_Pathway ko00760 Nicotinate and nicotinamide metabolism # Organism NADB_ECOLI Escherichia coli (strain K12) # PATHWAY Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (oxidase route) step 1/1. # PATRIC 32120547 VBIEscCol129921_2676 # PDB 1CHU X-ray; 2.20 A; A=1-540 # PDB 1KNP X-ray; 2.60 A; A=1-540 # PDB 1KNR X-ray; 2.50 A; A=1-540 # PIR E65035 OXECLD # PTM NADB_ECOLI Contains two disulfide bonds. # Pfam PF00890 FAD_binding_2 # Pfam PF02910 Succ_DH_flav_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NADB_ECOLI L-aspartate oxidase # RefSeq NP_417069 NC_000913.3 # RefSeq WP_001094491 NZ_LN832404.1 # SIMILARITY Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION NADB_ECOLI Cytoplasm. # SUBUNIT NADB_ECOLI Monomer. # SUPFAM SSF46977 SSF46977 # SUPFAM SSF51905 SSF51905; 2 # SUPFAM SSF56425 SSF56425 # TIGRFAMs TIGR00551 nadB # UniPathway UPA00253 UER00326 # eggNOG COG0029 LUCA # eggNOG ENOG4108IYU Bacteria BLAST swissprot:NADB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NADB_ECOLI BioCyc ECOL316407:JW2558-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2558-MONOMER BioCyc EcoCyc:L-ASPARTATE-OXID-MONOMER http://biocyc.org/getid?id=EcoCyc:L-ASPARTATE-OXID-MONOMER BioCyc MetaCyc:L-ASPARTATE-OXID-MONOMER http://biocyc.org/getid?id=MetaCyc:L-ASPARTATE-OXID-MONOMER COG COG0029 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0029 DIP DIP-556N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-556N DOI 10.1016/S0969-2126(99)80099-9 http://dx.doi.org/10.1016/S0969-2126(99)80099-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1432-1033.1988.tb14187.x http://dx.doi.org/10.1111/j.1432-1033.1988.tb14187.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB03147 http://www.drugbank.ca/drugs/DB03147 EC_number EC:1.4.3.16 http://www.genome.jp/dbget-bin/www_bget?EC:1.4.3.16 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D13169 http://www.ebi.ac.uk/ena/data/view/D13169 EMBL D64044 http://www.ebi.ac.uk/ena/data/view/D64044 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X12714 http://www.ebi.ac.uk/ena/data/view/X12714 ENZYME 1.4.3.16 http://enzyme.expasy.org/EC/1.4.3.16 EchoBASE EB0625 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0625 EcoGene EG10631 http://www.ecogene.org/geneInfo.php?eg_id=EG10631 EnsemblBacteria AAC75627 http://www.ensemblgenomes.org/id/AAC75627 EnsemblBacteria AAC75627 http://www.ensemblgenomes.org/id/AAC75627 EnsemblBacteria BAE76750 http://www.ensemblgenomes.org/id/BAE76750 EnsemblBacteria BAE76750 http://www.ensemblgenomes.org/id/BAE76750 EnsemblBacteria BAE76750 http://www.ensemblgenomes.org/id/BAE76750 EnsemblBacteria b2574 http://www.ensemblgenomes.org/id/b2574 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008734 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008734 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0044318 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044318 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_process GO:0009061 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009061 GO_process GO:0034628 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034628 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 1.20.58.100 http://www.cathdb.info/version/latest/superfamily/1.20.58.100 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 Gene3D 3.90.700.10 http://www.cathdb.info/version/latest/superfamily/3.90.700.10 GeneID 947049 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947049 HOGENOM HOG000160476 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000160476&db=HOGENOM6 InParanoid P10902 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P10902 IntAct P10902 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P10902* IntEnz 1.4.3.16 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.4.3.16 InterPro IPR003953 http://www.ebi.ac.uk/interpro/entry/IPR003953 InterPro IPR005288 http://www.ebi.ac.uk/interpro/entry/IPR005288 InterPro IPR015939 http://www.ebi.ac.uk/interpro/entry/IPR015939 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 InterPro IPR027477 http://www.ebi.ac.uk/interpro/entry/IPR027477 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2558 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2558 KEGG_Gene eco:b2574 http://www.genome.jp/dbget-bin/www_bget?eco:b2574 KEGG_Orthology KO:K00278 http://www.genome.jp/dbget-bin/www_bget?KO:K00278 KEGG_Pathway ko00250 http://www.genome.jp/kegg-bin/show_pathway?ko00250 KEGG_Pathway ko00760 http://www.genome.jp/kegg-bin/show_pathway?ko00760 KEGG_Reaction rn:R00357 http://www.genome.jp/dbget-bin/www_bget?rn:R00357 KEGG_Reaction rn:R00481 http://www.genome.jp/dbget-bin/www_bget?rn:R00481 OMA HCVQWLI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HCVQWLI PDB 1CHU http://www.ebi.ac.uk/pdbe-srv/view/entry/1CHU PDB 1KNP http://www.ebi.ac.uk/pdbe-srv/view/entry/1KNP PDB 1KNR http://www.ebi.ac.uk/pdbe-srv/view/entry/1KNR PDBsum 1CHU http://www.ebi.ac.uk/pdbsum/1CHU PDBsum 1KNP http://www.ebi.ac.uk/pdbsum/1KNP PDBsum 1KNR http://www.ebi.ac.uk/pdbsum/1KNR PSORT swissprot:NADB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NADB_ECOLI PSORT-B swissprot:NADB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NADB_ECOLI PSORT2 swissprot:NADB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NADB_ECOLI Pfam PF00890 http://pfam.xfam.org/family/PF00890 Pfam PF02910 http://pfam.xfam.org/family/PF02910 Phobius swissprot:NADB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NADB_ECOLI PhylomeDB P10902 http://phylomedb.org/?seqid=P10902 ProteinModelPortal P10902 http://www.proteinmodelportal.org/query/uniprot/P10902 PubMed 10425677 http://www.ncbi.nlm.nih.gov/pubmed/10425677 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2187483 http://www.ncbi.nlm.nih.gov/pubmed/2187483 PubMed 2841129 http://www.ncbi.nlm.nih.gov/pubmed/2841129 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417069 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417069 RefSeq WP_001094491 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001094491 SMR P10902 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P10902 STRING 511145.b2574 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2574&targetmode=cogs STRING COG0029 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0029&targetmode=cogs SUPFAM SSF46977 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46977 SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 SUPFAM SSF56425 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56425 TIGRFAMs TIGR00551 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00551 UniProtKB NADB_ECOLI http://www.uniprot.org/uniprot/NADB_ECOLI UniProtKB-AC P10902 http://www.uniprot.org/uniprot/P10902 charge swissprot:NADB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NADB_ECOLI eggNOG COG0029 http://eggnogapi.embl.de/nog_data/html/tree/COG0029 eggNOG ENOG4108IYU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108IYU epestfind swissprot:NADB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NADB_ECOLI garnier swissprot:NADB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NADB_ECOLI helixturnhelix swissprot:NADB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NADB_ECOLI hmoment swissprot:NADB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NADB_ECOLI iep swissprot:NADB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NADB_ECOLI inforesidue swissprot:NADB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NADB_ECOLI octanol swissprot:NADB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NADB_ECOLI pepcoil swissprot:NADB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NADB_ECOLI pepdigest swissprot:NADB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NADB_ECOLI pepinfo swissprot:NADB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NADB_ECOLI pepnet swissprot:NADB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NADB_ECOLI pepstats swissprot:NADB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NADB_ECOLI pepwheel swissprot:NADB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NADB_ECOLI pepwindow swissprot:NADB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NADB_ECOLI sigcleave swissprot:NADB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NADB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260738 182 # EcoGene EG10679 osmB # FUNCTION OSMB_ECOLI Provides resistance to osmotic stress. May be important for stationary-phase survival. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0019867 outer membrane; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # INDUCTION OSMB_ECOLI By elevated osmotic pressure in the growth medium. # InterPro IPR008816 Gly_zipper_2TM_dom # Organism OSMB_ECOLI Escherichia coli (strain K12) # PATRIC 32117830 VBIEscCol129921_1335 # PIR A32255 LPECOB # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF05433 Rick_17kDa_Anti # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName OSMB_ECOLI Osmotically-inducible lipoprotein B # RefSeq NP_415799 NC_000913.3 # RefSeq WP_000498253 NZ_LN832404.1 # SUBCELLULAR LOCATION OSMB_ECOLI Cell membrane {ECO 0000305}; Lipid-anchor {ECO 0000305}. BLAST swissprot:OSMB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:OSMB_ECOLI BioCyc ECOL316407:JW1275-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1275-MONOMER BioCyc EcoCyc:EG10679-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10679-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M22859 http://www.ebi.ac.uk/ena/data/view/M22859 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0673 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0673 EcoGene EG10679 http://www.ecogene.org/geneInfo.php?eg_id=EG10679 EnsemblBacteria AAC74365 http://www.ensemblgenomes.org/id/AAC74365 EnsemblBacteria AAC74365 http://www.ensemblgenomes.org/id/AAC74365 EnsemblBacteria BAA14837 http://www.ensemblgenomes.org/id/BAA14837 EnsemblBacteria BAA14837 http://www.ensemblgenomes.org/id/BAA14837 EnsemblBacteria BAA14837 http://www.ensemblgenomes.org/id/BAA14837 EnsemblBacteria b1283 http://www.ensemblgenomes.org/id/b1283 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0019867 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019867 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 945866 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945866 HOGENOM HOG000258374 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000258374&db=HOGENOM6 InParanoid P0ADA7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADA7 InterPro IPR008816 http://www.ebi.ac.uk/interpro/entry/IPR008816 KEGG_Gene ecj:JW1275 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1275 KEGG_Gene eco:b1283 http://www.genome.jp/dbget-bin/www_bget?eco:b1283 KEGG_Orthology KO:K04062 http://www.genome.jp/dbget-bin/www_bget?KO:K04062 OMA SHRQKST http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SHRQKST PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:OSMB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:OSMB_ECOLI PSORT-B swissprot:OSMB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:OSMB_ECOLI PSORT2 swissprot:OSMB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:OSMB_ECOLI Pfam PF05433 http://pfam.xfam.org/family/PF05433 Phobius swissprot:OSMB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:OSMB_ECOLI ProteinModelPortal P0ADA7 http://www.proteinmodelportal.org/query/uniprot/P0ADA7 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2644204 http://www.ncbi.nlm.nih.gov/pubmed/2644204 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415799 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415799 RefSeq WP_000498253 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000498253 STRING 511145.b1283 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1283&targetmode=cogs UniProtKB OSMB_ECOLI http://www.uniprot.org/uniprot/OSMB_ECOLI UniProtKB-AC P0ADA7 http://www.uniprot.org/uniprot/P0ADA7 charge swissprot:OSMB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:OSMB_ECOLI epestfind swissprot:OSMB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:OSMB_ECOLI garnier swissprot:OSMB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:OSMB_ECOLI helixturnhelix swissprot:OSMB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:OSMB_ECOLI hmoment swissprot:OSMB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:OSMB_ECOLI iep swissprot:OSMB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:OSMB_ECOLI inforesidue swissprot:OSMB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:OSMB_ECOLI octanol swissprot:OSMB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:OSMB_ECOLI pepcoil swissprot:OSMB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:OSMB_ECOLI pepdigest swissprot:OSMB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:OSMB_ECOLI pepinfo swissprot:OSMB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:OSMB_ECOLI pepnet swissprot:OSMB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:OSMB_ECOLI pepstats swissprot:OSMB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:OSMB_ECOLI pepwheel swissprot:OSMB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:OSMB_ECOLI pepwindow swissprot:OSMB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:OSMB_ECOLI sigcleave swissprot:OSMB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:OSMB_ECOLI ## Database ID URL or Descriptions # AltName HYCB_ECOLI Hydrogenase-3 component B # BioGrid 4262103 6 # COFACTOR HYCB_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000250}; Note=Binds 4 [4Fe-4S] clusters. {ECO 0000250}; # EcoGene EG10475 hycB # FUNCTION HYCB_ECOLI Probable electron transfer protein for hydrogenase 3. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0055114 oxidation-reduction process; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # IntAct P0AAK1 4 # InterPro IPR017896 4Fe4S_Fe-S-bd # InterPro IPR017900 4Fe4S_Fe_S_CS # Organism HYCB_ECOLI Escherichia coli (strain K12) # PATRIC 32120848 VBIEscCol129921_2816 # PIR H65052 H65052 # PROSITE PS00198 4FE4S_FER_1 # PROSITE PS51379 4FE4S_FER_2; 4 # Pfam PF13247 Fer4_11 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HYCB_ECOLI Formate hydrogenlyase subunit 2 # RefSeq NP_417204 NC_000913.3 # RefSeq WP_001079186 NZ_LN832404.1 # SIMILARITY Contains 4 4Fe-4S ferredoxin-type domains. {ECO:0000255|PROSITE-ProRule PRU00711}. # SUBUNIT HYCB_ECOLI FHL comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (isoenzyme 3). In this non- energy conserving pathway, molecular hydrogen and carbodioxide are released from formate. # eggNOG COG1142 LUCA # eggNOG ENOG4108MFN Bacteria BLAST swissprot:HYCB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HYCB_ECOLI BioCyc ECOL316407:JW2694-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2694-MONOMER BioCyc EcoCyc:HYCBSMALL-MONOMER http://biocyc.org/getid?id=EcoCyc:HYCBSMALL-MONOMER BioCyc MetaCyc:HYCBSMALL-MONOMER http://biocyc.org/getid?id=MetaCyc:HYCBSMALL-MONOMER COG COG1142 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1142 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1990.tb00590.x http://dx.doi.org/10.1111/j.1365-2958.1990.tb00590.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EMBL X17506 http://www.ebi.ac.uk/ena/data/view/X17506 EchoBASE EB0470 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0470 EcoGene EG10475 http://www.ecogene.org/geneInfo.php?eg_id=EG10475 EnsemblBacteria AAC75766 http://www.ensemblgenomes.org/id/AAC75766 EnsemblBacteria AAC75766 http://www.ensemblgenomes.org/id/AAC75766 EnsemblBacteria BAE76801 http://www.ensemblgenomes.org/id/BAE76801 EnsemblBacteria BAE76801 http://www.ensemblgenomes.org/id/BAE76801 EnsemblBacteria BAE76801 http://www.ensemblgenomes.org/id/BAE76801 EnsemblBacteria b2724 http://www.ensemblgenomes.org/id/b2724 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0055114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 948002 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948002 HOGENOM HOG000163385 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000163385&db=HOGENOM6 InParanoid P0AAK1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAK1 IntAct P0AAK1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAK1* InterPro IPR017896 http://www.ebi.ac.uk/interpro/entry/IPR017896 InterPro IPR017900 http://www.ebi.ac.uk/interpro/entry/IPR017900 KEGG_Gene ecj:JW2694 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2694 KEGG_Gene eco:b2724 http://www.genome.jp/dbget-bin/www_bget?eco:b2724 KEGG_Orthology KO:K15827 http://www.genome.jp/dbget-bin/www_bget?KO:K15827 OMA RTCPTKA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RTCPTKA PROSITE PS00198 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00198 PROSITE PS51379 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51379 PSORT swissprot:HYCB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HYCB_ECOLI PSORT-B swissprot:HYCB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HYCB_ECOLI PSORT2 swissprot:HYCB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HYCB_ECOLI Pfam PF13247 http://pfam.xfam.org/family/PF13247 Phobius swissprot:HYCB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HYCB_ECOLI PhylomeDB P0AAK1 http://phylomedb.org/?seqid=P0AAK1 ProteinModelPortal P0AAK1 http://www.proteinmodelportal.org/query/uniprot/P0AAK1 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2187144 http://www.ncbi.nlm.nih.gov/pubmed/2187144 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417204 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417204 RefSeq WP_001079186 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001079186 STRING 511145.b2724 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2724&targetmode=cogs STRING COG1142 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1142&targetmode=cogs UniProtKB HYCB_ECOLI http://www.uniprot.org/uniprot/HYCB_ECOLI UniProtKB-AC P0AAK1 http://www.uniprot.org/uniprot/P0AAK1 charge swissprot:HYCB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HYCB_ECOLI eggNOG COG1142 http://eggnogapi.embl.de/nog_data/html/tree/COG1142 eggNOG ENOG4108MFN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MFN epestfind swissprot:HYCB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HYCB_ECOLI garnier swissprot:HYCB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HYCB_ECOLI helixturnhelix swissprot:HYCB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HYCB_ECOLI hmoment swissprot:HYCB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HYCB_ECOLI iep swissprot:HYCB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HYCB_ECOLI inforesidue swissprot:HYCB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HYCB_ECOLI octanol swissprot:HYCB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HYCB_ECOLI pepcoil swissprot:HYCB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HYCB_ECOLI pepdigest swissprot:HYCB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HYCB_ECOLI pepinfo swissprot:HYCB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HYCB_ECOLI pepnet swissprot:HYCB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HYCB_ECOLI pepstats swissprot:HYCB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HYCB_ECOLI pepwheel swissprot:HYCB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HYCB_ECOLI pepwindow swissprot:HYCB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HYCB_ECOLI sigcleave swissprot:HYCB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HYCB_ECOLI ## Database ID URL or Descriptions # AltName OTSB_ECOLI Osmoregulatory trehalose synthesis protein B # AltName OTSB_ECOLI Trehalose 6-phosphate phosphatase # AltName OTSB_ECOLI Trehalose-phosphatase # BIOPHYSICOCHEMICAL PROPERTIES OTSB_ECOLI Kinetic parameters KM=0.61 mM for Tre6P (with magnesium ions as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; pH dependence Optimum pH is between 6 and 7.5. {ECO 0000269|PubMed 16990279}; # BioGrid 4262243 10 # CATALYTIC ACTIVITY OTSB_ECOLI Trehalose 6-phosphate + H(2)O = trehalose + phosphate. # COFACTOR OTSB_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 16990279}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 16990279}; Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000269|PubMed 16990279}; Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 16990279}; Note=Magnesium. Can also use other divalent metal cations as manganese, cobalt or zinc. {ECO 0000269|PubMed 16990279}; # EcoGene EG11752 otsB # FUNCTION OTSB_ECOLI Removes the phosphate from trehalose 6-phosphate (Tre6P) to produce free trehalose. Also catalyzes the dephosphorylation of glucose-6-phosphate (Glu6P) and 2-deoxyglucose-6-phosphate (2dGlu6P). {ECO 0000269|PubMed 1310094, ECO 0000269|PubMed 16990279}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0000287 magnesium ion binding; IDA:UniProtKB. # GO_function GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity; IBA:GO_Central. # GO_function GO:0004805 trehalose-phosphatase activity; IDA:EcoCyc. # GO_process GO:0005992 trehalose biosynthetic process; IMP:EcoCyc. # GO_process GO:0006970 response to osmotic stress; IEP:EcoCyc. # GO_process GO:0070415 trehalose metabolism in response to cold stress; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.1000 -; 2. # INDUCTION OTSB_ECOLI By cold-shock, osmotic-shock and during the transition to stationary phase. Expression is partially dependent on RpoS. {ECO 0000269|PubMed 12105274, ECO 0000269|PubMed 1310094, ECO 0000269|PubMed 17015655, ECO 0000269|PubMed 1744047, ECO 0000269|PubMed 3131312}. # IntAct P31678 15 # InterPro IPR003337 Trehalose_PPase # InterPro IPR006379 HAD-SF_hydro_IIB # InterPro IPR023214 HAD-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00500 Starch and sucrose metabolism # Organism OTSB_ECOLI Escherichia coli (strain K12) # PATHWAY OTSB_ECOLI Glycan biosynthesis; trehalose biosynthesis. # PATRIC 32119121 VBIEscCol129921_1978 # PIR I83401 I83401 # Pfam PF02358 Trehalose_PPase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName OTSB_ECOLI Trehalose-6-phosphate phosphatase # RefSeq NP_416411 NC_000913.3 # RefSeq WP_001295645 NZ_LN832404.1 # SIMILARITY Belongs to the trehalose phosphatase family. {ECO 0000305}. # SUPFAM SSF56784 SSF56784 # TIGRFAMs TIGR00685 T6PP # TIGRFAMs TIGR01484 HAD-SF-IIB # eggNOG COG1877 LUCA # eggNOG ENOG4108K4C Bacteria BLAST swissprot:OTSB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:OTSB_ECOLI BioCyc ECOL316407:JW1886-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1886-MONOMER BioCyc EcoCyc:TREHALOSEPHOSPHASYN-MONOMER http://biocyc.org/getid?id=EcoCyc:TREHALOSEPHOSPHASYN-MONOMER BioCyc MetaCyc:TREHALOSEPHOSPHASYN-MONOMER http://biocyc.org/getid?id=MetaCyc:TREHALOSEPHOSPHASYN-MONOMER COG COG1877 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1877 DOI 10.1016/0378-1119(94)90316-6 http://dx.doi.org/10.1016/0378-1119(94)90316-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.142314099 http://dx.doi.org/10.1073/pnas.142314099 DOI 10.1074/jbc.M605449200 http://dx.doi.org/10.1074/jbc.M605449200 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00508-06 http://dx.doi.org/10.1128/JB.00508-06 EC_number EC:3.1.3.12 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.12 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X69160 http://www.ebi.ac.uk/ena/data/view/X69160 ENZYME 3.1.3.12 http://enzyme.expasy.org/EC/3.1.3.12 EchoBASE EB1702 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1702 EcoGene EG11752 http://www.ecogene.org/geneInfo.php?eg_id=EG11752 EnsemblBacteria AAC74967 http://www.ensemblgenomes.org/id/AAC74967 EnsemblBacteria AAC74967 http://www.ensemblgenomes.org/id/AAC74967 EnsemblBacteria BAA15718 http://www.ensemblgenomes.org/id/BAA15718 EnsemblBacteria BAA15718 http://www.ensemblgenomes.org/id/BAA15718 EnsemblBacteria BAA15718 http://www.ensemblgenomes.org/id/BAA15718 EnsemblBacteria b1897 http://www.ensemblgenomes.org/id/b1897 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0003825 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003825 GO_function GO:0004805 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004805 GO_process GO:0005992 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005992 GO_process GO:0006970 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006970 GO_process GO:0070415 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070415 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.1000 http://www.cathdb.info/version/latest/superfamily/3.40.50.1000 GeneID 946406 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946406 HOGENOM HOG000239290 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000239290&db=HOGENOM6 InParanoid P31678 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31678 IntAct P31678 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31678* IntEnz 3.1.3.12 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.12 InterPro IPR003337 http://www.ebi.ac.uk/interpro/entry/IPR003337 InterPro IPR006379 http://www.ebi.ac.uk/interpro/entry/IPR006379 InterPro IPR023214 http://www.ebi.ac.uk/interpro/entry/IPR023214 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1886 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1886 KEGG_Gene eco:b1897 http://www.genome.jp/dbget-bin/www_bget?eco:b1897 KEGG_Orthology KO:K01087 http://www.genome.jp/dbget-bin/www_bget?KO:K01087 KEGG_Pathway ko00500 http://www.genome.jp/kegg-bin/show_pathway?ko00500 KEGG_Reaction rn:R02778 http://www.genome.jp/dbget-bin/www_bget?rn:R02778 OMA WAMFLDI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WAMFLDI PSORT swissprot:OTSB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:OTSB_ECOLI PSORT-B swissprot:OTSB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:OTSB_ECOLI PSORT2 swissprot:OTSB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:OTSB_ECOLI Pfam PF02358 http://pfam.xfam.org/family/PF02358 Phobius swissprot:OTSB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:OTSB_ECOLI PhylomeDB P31678 http://phylomedb.org/?seqid=P31678 ProteinModelPortal P31678 http://www.proteinmodelportal.org/query/uniprot/P31678 PubMed 12105274 http://www.ncbi.nlm.nih.gov/pubmed/12105274 PubMed 1310094 http://www.ncbi.nlm.nih.gov/pubmed/1310094 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16990279 http://www.ncbi.nlm.nih.gov/pubmed/16990279 PubMed 17015655 http://www.ncbi.nlm.nih.gov/pubmed/17015655 PubMed 1744047 http://www.ncbi.nlm.nih.gov/pubmed/1744047 PubMed 3131312 http://www.ncbi.nlm.nih.gov/pubmed/3131312 PubMed 8045430 http://www.ncbi.nlm.nih.gov/pubmed/8045430 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416411 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416411 RefSeq WP_001295645 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295645 SMR P31678 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31678 STRING 511145.b1897 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1897&targetmode=cogs STRING COG1877 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1877&targetmode=cogs SUPFAM SSF56784 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784 SWISS-2DPAGE P31678 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P31678 TIGRFAMs TIGR00685 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00685 TIGRFAMs TIGR01484 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01484 UniProtKB OTSB_ECOLI http://www.uniprot.org/uniprot/OTSB_ECOLI UniProtKB-AC P31678 http://www.uniprot.org/uniprot/P31678 charge swissprot:OTSB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:OTSB_ECOLI eggNOG COG1877 http://eggnogapi.embl.de/nog_data/html/tree/COG1877 eggNOG ENOG4108K4C http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108K4C epestfind swissprot:OTSB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:OTSB_ECOLI garnier swissprot:OTSB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:OTSB_ECOLI helixturnhelix swissprot:OTSB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:OTSB_ECOLI hmoment swissprot:OTSB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:OTSB_ECOLI iep swissprot:OTSB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:OTSB_ECOLI inforesidue swissprot:OTSB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:OTSB_ECOLI octanol swissprot:OTSB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:OTSB_ECOLI pepcoil swissprot:OTSB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:OTSB_ECOLI pepdigest swissprot:OTSB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:OTSB_ECOLI pepinfo swissprot:OTSB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:OTSB_ECOLI pepnet swissprot:OTSB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:OTSB_ECOLI pepstats swissprot:OTSB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:OTSB_ECOLI pepwheel swissprot:OTSB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:OTSB_ECOLI pepwindow swissprot:OTSB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:OTSB_ECOLI sigcleave swissprot:OTSB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:OTSB_ECOLI ## Database ID URL or Descriptions # AltName FDNI_ECOLI Anaerobic formate dehydrogenase cytochrome b556 subunit # AltName FDNI_ECOLI Formate dehydrogenase-N subunit gamma # BRENDA 1.1.5 2026 # BioGrid 4262903 6 # COFACTOR FDNI_ECOLI Name=heme; Xref=ChEBI CHEBI 30413; Evidence={ECO 0000269|PubMed 11884747}; Note=Binds 2 heme groups per subunit. Heme 1 is located at the cytoplasmic interface, heme 2 is located at the periplasmic interface. Electrons are transferred from the periplasmic to the cytoplasmic heme. {ECO 0000269|PubMed 11884747}; # EcoGene EG11229 fdnI # FUNCTION FDNI_ECOLI Formate dehydrogenase allows E.coli to use formate as major electron donor during anaerobic respiration, when nitrate is used as electron acceptor. Subunit gamma is the cytochrome b556 component of the formate dehydrogenase-N, and also contains a menaquinone reduction site that receives electrons from the beta subunit (FdnH), through its hemes. Formate dehydrogenase-N is part of a system that generates proton motive force, together with the dissimilatory nitrate reductase (Nar). {ECO 0000269|PubMed 11884747}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0009326 formate dehydrogenase complex; IDA:EcoCyc. # GO_function GO:0008863 formate dehydrogenase (NAD+) activity; IEA:InterPro. # GO_function GO:0009055 electron carrier activity; IDA:EcoCyc. # GO_function GO:0020037 heme binding; IDA:EcoCyc. # GO_function GO:0036397 formate dehydrogenase (quinone) activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0009061 anaerobic respiration; IEP:EcoCyc. # GO_process GO:0015944 formate oxidation; IDA:EcoCyc. # GO_process GO:0022904 respiratory electron transport chain; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0044281 small molecule metabolic process # INDUCTION By nitrate under anaerobic conditions. {ECO:0000269|PubMed 2168848}. # InterPro IPR006471 Formate_DH_gsu # InterPro IPR011577 Cyt_b561_bac/Ni-Hgenase # InterPro IPR016174 Di-haem_cyt_TM # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Pathway ko00630 Glyoxylate and dicarboxylate metabolism # KEGG_Pathway ko00680 Methane metabolism # KEGG_Pathway ko02020 Two-component system # Organism FDNI_ECOLI Escherichia coli (strain K12) # PATRIC 32118244 VBIEscCol129921_1542 # PDB 1KQF X-ray; 1.60 A; C=1-217 # PDB 1KQG X-ray; 2.80 A; C=1-217 # PIR G64900 JS0630 # Pfam PF01292 Ni_hydr_CYTB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FDNI_ECOLI Formate dehydrogenase, nitrate-inducible, cytochrome b556(Fdn) subunit # RefSeq NP_415993 NC_000913.3 # RefSeq WP_000045648 NZ_LN832404.1 # SIMILARITY Belongs to the formate dehydrogenase gamma subunit family. {ECO 0000305}. # SUBCELLULAR LOCATION FDNI_ECOLI Cell inner membrane {ECO 0000269|PubMed 11884747}; Multi-pass membrane protein {ECO 0000269|PubMed 11884747}. # SUBUNIT Trimer of heterotrimers, consisting of subunits alpha, beta and gamma. {ECO:0000269|PubMed 11884747}. # SUPFAM SSF81342 SSF81342 # TCDB 5.A.3.2 the prokaryotic molybdopterin-containing oxidoreductase (pmo) family # TIGRFAMs TIGR01583 formate-DH-gamm # eggNOG COG2864 LUCA # eggNOG ENOG4108MG3 Bacteria BLAST swissprot:FDNI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FDNI_ECOLI BioCyc ECOL316407:JW1472-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1472-MONOMER BioCyc EcoCyc:FDNI-MONOMER http://biocyc.org/getid?id=EcoCyc:FDNI-MONOMER BioCyc MetaCyc:FDNI-MONOMER http://biocyc.org/getid?id=MetaCyc:FDNI-MONOMER COG COG2864 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2864 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1068186 http://dx.doi.org/10.1126/science.1068186 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M75029 http://www.ebi.ac.uk/ena/data/view/M75029 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1211 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1211 EcoGene EG11229 http://www.ecogene.org/geneInfo.php?eg_id=EG11229 EnsemblBacteria AAD13440 http://www.ensemblgenomes.org/id/AAD13440 EnsemblBacteria AAD13440 http://www.ensemblgenomes.org/id/AAD13440 EnsemblBacteria BAA15125 http://www.ensemblgenomes.org/id/BAA15125 EnsemblBacteria BAA15125 http://www.ensemblgenomes.org/id/BAA15125 EnsemblBacteria BAA15125 http://www.ensemblgenomes.org/id/BAA15125 EnsemblBacteria b1476 http://www.ensemblgenomes.org/id/b1476 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0009326 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009326 GO_function GO:0008863 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008863 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0020037 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0020037 GO_function GO:0036397 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036397 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0009061 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009061 GO_process GO:0015944 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015944 GO_process GO:0022904 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022904 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 946038 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946038 HOGENOM HOG000163500 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000163500&db=HOGENOM6 InParanoid P0AEK7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEK7 IntAct P0AEK7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEK7* InterPro IPR006471 http://www.ebi.ac.uk/interpro/entry/IPR006471 InterPro IPR011577 http://www.ebi.ac.uk/interpro/entry/IPR011577 InterPro IPR016174 http://www.ebi.ac.uk/interpro/entry/IPR016174 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Gene ecj:JW1472 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1472 KEGG_Gene eco:b1476 http://www.genome.jp/dbget-bin/www_bget?eco:b1476 KEGG_Orthology KO:K08350 http://www.genome.jp/dbget-bin/www_bget?KO:K08350 KEGG_Pathway ko00630 http://www.genome.jp/kegg-bin/show_pathway?ko00630 KEGG_Pathway ko00680 http://www.genome.jp/kegg-bin/show_pathway?ko00680 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 KEGG_Reaction rn:R00519 http://www.genome.jp/dbget-bin/www_bget?rn:R00519 OMA KQDIPWL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KQDIPWL PDB 1KQF http://www.ebi.ac.uk/pdbe-srv/view/entry/1KQF PDB 1KQG http://www.ebi.ac.uk/pdbe-srv/view/entry/1KQG PDBsum 1KQF http://www.ebi.ac.uk/pdbsum/1KQF PDBsum 1KQG http://www.ebi.ac.uk/pdbsum/1KQG PSORT swissprot:FDNI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FDNI_ECOLI PSORT-B swissprot:FDNI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FDNI_ECOLI PSORT2 swissprot:FDNI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FDNI_ECOLI Pfam PF01292 http://pfam.xfam.org/family/PF01292 Phobius swissprot:FDNI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FDNI_ECOLI PhylomeDB P0AEK7 http://phylomedb.org/?seqid=P0AEK7 ProteinModelPortal P0AEK7 http://www.proteinmodelportal.org/query/uniprot/P0AEK7 PubMed 11884747 http://www.ncbi.nlm.nih.gov/pubmed/11884747 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1834669 http://www.ncbi.nlm.nih.gov/pubmed/1834669 PubMed 2168848 http://www.ncbi.nlm.nih.gov/pubmed/2168848 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415993 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415993 RefSeq WP_000045648 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000045648 SMR P0AEK7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEK7 STRING 511145.b1476 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1476&targetmode=cogs STRING COG2864 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2864&targetmode=cogs SUPFAM SSF81342 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81342 TCDB 5.A.3.2 http://www.tcdb.org/search/result.php?tc=5.A.3.2 TIGRFAMs TIGR01583 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01583 UniProtKB FDNI_ECOLI http://www.uniprot.org/uniprot/FDNI_ECOLI UniProtKB-AC P0AEK7 http://www.uniprot.org/uniprot/P0AEK7 charge swissprot:FDNI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FDNI_ECOLI eggNOG COG2864 http://eggnogapi.embl.de/nog_data/html/tree/COG2864 eggNOG ENOG4108MG3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MG3 epestfind swissprot:FDNI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FDNI_ECOLI garnier swissprot:FDNI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FDNI_ECOLI helixturnhelix swissprot:FDNI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FDNI_ECOLI hmoment swissprot:FDNI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FDNI_ECOLI iep swissprot:FDNI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FDNI_ECOLI inforesidue swissprot:FDNI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FDNI_ECOLI octanol swissprot:FDNI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FDNI_ECOLI pepcoil swissprot:FDNI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FDNI_ECOLI pepdigest swissprot:FDNI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FDNI_ECOLI pepinfo swissprot:FDNI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FDNI_ECOLI pepnet swissprot:FDNI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FDNI_ECOLI pepstats swissprot:FDNI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FDNI_ECOLI pepwheel swissprot:FDNI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FDNI_ECOLI pepwindow swissprot:FDNI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FDNI_ECOLI sigcleave swissprot:FDNI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FDNI_ECOLI ## Database ID URL or Descriptions # BioGrid 4260339 164 # EcoGene EG13511 yeaY # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0019867 outer membrane; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # IntAct P0AA91 4 # InterPro IPR004658 OMP_Slp # Organism YEAY_ECOLI Escherichia coli (strain K12) # PATRIC 32118929 VBIEscCol129921_1882 # PIR F64941 F64941 # PIRSF PIRSF004982 SlP # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF03843 Slp # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEAY_ECOLI Uncharacterized lipoprotein YeaY # RefSeq NP_416320 NC_000913.3 # RefSeq WP_000290576 NZ_LN832404.1 # SUBCELLULAR LOCATION YEAY_ECOLI Cell membrane {ECO 0000255|PROSITE- ProRule PRU00303}; Lipid-anchor {ECO 0000255|PROSITE- ProRule PRU00303}. # TIGRFAMs TIGR00752 slp # eggNOG COG3065 LUCA # eggNOG ENOG4105Y4Z Bacteria BLAST swissprot:YEAY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEAY_ECOLI BioCyc ECOL316407:JW1795-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1795-MONOMER BioCyc EcoCyc:G6990-MONOMER http://biocyc.org/getid?id=EcoCyc:G6990-MONOMER COG COG3065 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3065 DIP DIP-28087N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-28087N DOI 10.1007/BF00280412 http://dx.doi.org/10.1007/BF00280412 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3284 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3284 EcoGene EG13511 http://www.ecogene.org/geneInfo.php?eg_id=EG13511 EnsemblBacteria AAC74876 http://www.ensemblgenomes.org/id/AAC74876 EnsemblBacteria AAC74876 http://www.ensemblgenomes.org/id/AAC74876 EnsemblBacteria BAA15610 http://www.ensemblgenomes.org/id/BAA15610 EnsemblBacteria BAA15610 http://www.ensemblgenomes.org/id/BAA15610 EnsemblBacteria BAA15610 http://www.ensemblgenomes.org/id/BAA15610 EnsemblBacteria b1806 http://www.ensemblgenomes.org/id/b1806 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0019867 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019867 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 946312 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946312 HOGENOM HOG000277549 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000277549&db=HOGENOM6 InParanoid P0AA91 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AA91 IntAct P0AA91 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AA91* InterPro IPR004658 http://www.ebi.ac.uk/interpro/entry/IPR004658 KEGG_Gene ecj:JW1795 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1795 KEGG_Gene eco:b1806 http://www.genome.jp/dbget-bin/www_bget?eco:b1806 KEGG_Orthology KO:K07285 http://www.genome.jp/dbget-bin/www_bget?KO:K07285 OMA NEAHRTR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NEAHRTR PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YEAY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEAY_ECOLI PSORT-B swissprot:YEAY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEAY_ECOLI PSORT2 swissprot:YEAY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEAY_ECOLI Pfam PF03843 http://pfam.xfam.org/family/PF03843 Phobius swissprot:YEAY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEAY_ECOLI PhylomeDB P0AA91 http://phylomedb.org/?seqid=P0AA91 ProteinModelPortal P0AA91 http://www.proteinmodelportal.org/query/uniprot/P0AA91 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8107670 http://www.ncbi.nlm.nih.gov/pubmed/8107670 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416320 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416320 RefSeq WP_000290576 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000290576 STRING 511145.b1806 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1806&targetmode=cogs STRING COG3065 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3065&targetmode=cogs TIGRFAMs TIGR00752 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00752 UniProtKB YEAY_ECOLI http://www.uniprot.org/uniprot/YEAY_ECOLI UniProtKB-AC P0AA91 http://www.uniprot.org/uniprot/P0AA91 charge swissprot:YEAY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEAY_ECOLI eggNOG COG3065 http://eggnogapi.embl.de/nog_data/html/tree/COG3065 eggNOG ENOG4105Y4Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105Y4Z epestfind swissprot:YEAY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEAY_ECOLI garnier swissprot:YEAY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEAY_ECOLI helixturnhelix swissprot:YEAY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEAY_ECOLI hmoment swissprot:YEAY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEAY_ECOLI iep swissprot:YEAY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEAY_ECOLI inforesidue swissprot:YEAY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEAY_ECOLI octanol swissprot:YEAY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEAY_ECOLI pepcoil swissprot:YEAY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEAY_ECOLI pepdigest swissprot:YEAY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEAY_ECOLI pepinfo swissprot:YEAY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEAY_ECOLI pepnet swissprot:YEAY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEAY_ECOLI pepstats swissprot:YEAY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEAY_ECOLI pepwheel swissprot:YEAY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEAY_ECOLI pepwindow swissprot:YEAY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEAY_ECOLI sigcleave swissprot:YEAY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEAY_ECOLI ## Database ID URL or Descriptions # BioGrid 4263375 4 # EcoGene EG12521 yjfN # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GOslim_component GO:0005575 cellular_component # Gene3D 3.30.1660.10 -; 1. # IntAct P0AF82 5 # InterPro IPR010854 DUF1471 # InterPro IPR025543 Dodecin-like # Organism YJFN_ECOLI Escherichia coli (strain K12) # PATRIC 32123951 VBIEscCol129921_4320 # PIR S56413 S56413 # Pfam PF07338 DUF1471 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJFN_ECOLI Uncharacterized protein YjfN # RefSeq NP_418609 NC_000913.3 # RefSeq WP_000811566 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97084.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the BhsA/McbA family. {ECO 0000305}. # SUBCELLULAR LOCATION YJFN_ECOLI Periplasm {ECO 0000305}. # SUPFAM SSF159871 SSF159871 # eggNOG ENOG4105S17 Bacteria # eggNOG ENOG4111X9K LUCA BLAST swissprot:YJFN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJFN_ECOLI BioCyc ECOL316407:JW5742-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5742-MONOMER BioCyc EcoCyc:G7851-MONOMER http://biocyc.org/getid?id=EcoCyc:G7851-MONOMER DIP DIP-48101N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48101N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2412 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2412 EcoGene EG12521 http://www.ecogene.org/geneInfo.php?eg_id=EG12521 EnsemblBacteria AAC77145 http://www.ensemblgenomes.org/id/AAC77145 EnsemblBacteria AAC77145 http://www.ensemblgenomes.org/id/AAC77145 EnsemblBacteria BAE78189 http://www.ensemblgenomes.org/id/BAE78189 EnsemblBacteria BAE78189 http://www.ensemblgenomes.org/id/BAE78189 EnsemblBacteria BAE78189 http://www.ensemblgenomes.org/id/BAE78189 EnsemblBacteria b4188 http://www.ensemblgenomes.org/id/b4188 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 Gene3D 3.30.1660.10 http://www.cathdb.info/version/latest/superfamily/3.30.1660.10 GeneID 948709 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948709 HOGENOM HOG000117400 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117400&db=HOGENOM6 IntAct P0AF82 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AF82* InterPro IPR010854 http://www.ebi.ac.uk/interpro/entry/IPR010854 InterPro IPR025543 http://www.ebi.ac.uk/interpro/entry/IPR025543 KEGG_Gene ecj:JW5742 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5742 KEGG_Gene eco:b4188 http://www.genome.jp/dbget-bin/www_bget?eco:b4188 MINT MINT-1292789 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1292789 OMA EQQPDNW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EQQPDNW PSORT swissprot:YJFN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJFN_ECOLI PSORT-B swissprot:YJFN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJFN_ECOLI PSORT2 swissprot:YJFN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJFN_ECOLI Pfam PF07338 http://pfam.xfam.org/family/PF07338 Phobius swissprot:YJFN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJFN_ECOLI ProteinModelPortal P0AF82 http://www.proteinmodelportal.org/query/uniprot/P0AF82 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418609 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418609 RefSeq WP_000811566 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000811566 STRING 511145.b4188 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4188&targetmode=cogs SUPFAM SSF159871 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF159871 UniProtKB YJFN_ECOLI http://www.uniprot.org/uniprot/YJFN_ECOLI UniProtKB-AC P0AF82 http://www.uniprot.org/uniprot/P0AF82 charge swissprot:YJFN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJFN_ECOLI eggNOG ENOG4105S17 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105S17 eggNOG ENOG4111X9K http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111X9K epestfind swissprot:YJFN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJFN_ECOLI garnier swissprot:YJFN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJFN_ECOLI helixturnhelix swissprot:YJFN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJFN_ECOLI hmoment swissprot:YJFN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJFN_ECOLI iep swissprot:YJFN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJFN_ECOLI inforesidue swissprot:YJFN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJFN_ECOLI octanol swissprot:YJFN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJFN_ECOLI pepcoil swissprot:YJFN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJFN_ECOLI pepdigest swissprot:YJFN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJFN_ECOLI pepinfo swissprot:YJFN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJFN_ECOLI pepnet swissprot:YJFN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJFN_ECOLI pepstats swissprot:YJFN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJFN_ECOLI pepwheel swissprot:YJFN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJFN_ECOLI pepwindow swissprot:YJFN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJFN_ECOLI sigcleave swissprot:YJFN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJFN_ECOLI ## Database ID URL or Descriptions # BioGrid 4260137 9 # EcoGene EG11125 yciE # GO_process GO:0006974 cellular response to DNA damage stimulus; IBA:GO_Central. # GOslim_process GO:0006950 response to stress # Gene3D 1.20.1260.10 -; 1. # IntAct P21363 4 # InterPro IPR009078 Ferritin-like_SF # InterPro IPR010287 DUF892 # InterPro IPR012347 Ferritin-rel # Organism YCIE_ECOLI Escherichia coli (strain K12) # PATRIC 32117774 VBIEscCol129921_1307 # PIR S07796 S07796 # Pfam PF05974 DUF892 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCIE_ECOLI Protein YciE # RefSeq NP_415773 NC_000913.3 # RefSeq WP_001079505 NZ_LN832404.1 # SUPFAM SSF47240 SSF47240 # eggNOG COG3685 LUCA # eggNOG ENOG4108N8X Bacteria BLAST swissprot:YCIE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCIE_ECOLI BioCyc ECOL316407:JW1249-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1249-MONOMER BioCyc EcoCyc:EG11125-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11125-MONOMER DIP DIP-11579N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11579N DOI 10.1007/BF00282791 http://dx.doi.org/10.1007/BF00282791 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U23489 http://www.ebi.ac.uk/ena/data/view/U23489 EMBL U23490 http://www.ebi.ac.uk/ena/data/view/U23490 EMBL U23491 http://www.ebi.ac.uk/ena/data/view/U23491 EMBL U23492 http://www.ebi.ac.uk/ena/data/view/U23492 EMBL U25417 http://www.ebi.ac.uk/ena/data/view/U25417 EMBL U25418 http://www.ebi.ac.uk/ena/data/view/U25418 EMBL U25419 http://www.ebi.ac.uk/ena/data/view/U25419 EMBL U25420 http://www.ebi.ac.uk/ena/data/view/U25420 EMBL U25422 http://www.ebi.ac.uk/ena/data/view/U25422 EMBL X13583 http://www.ebi.ac.uk/ena/data/view/X13583 EchoBASE EB1115 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1115 EcoGene EG11125 http://www.ecogene.org/geneInfo.php?eg_id=EG11125 EnsemblBacteria AAC74339 http://www.ensemblgenomes.org/id/AAC74339 EnsemblBacteria AAC74339 http://www.ensemblgenomes.org/id/AAC74339 EnsemblBacteria BAA14789 http://www.ensemblgenomes.org/id/BAA14789 EnsemblBacteria BAA14789 http://www.ensemblgenomes.org/id/BAA14789 EnsemblBacteria BAA14789 http://www.ensemblgenomes.org/id/BAA14789 EnsemblBacteria b1257 http://www.ensemblgenomes.org/id/b1257 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 1.20.1260.10 http://www.cathdb.info/version/latest/superfamily/1.20.1260.10 GeneID 946871 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946871 HOGENOM HOG000268354 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000268354&db=HOGENOM6 InParanoid P21363 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P21363 IntAct P21363 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P21363* InterPro IPR009078 http://www.ebi.ac.uk/interpro/entry/IPR009078 InterPro IPR010287 http://www.ebi.ac.uk/interpro/entry/IPR010287 InterPro IPR012347 http://www.ebi.ac.uk/interpro/entry/IPR012347 KEGG_Gene ecj:JW1249 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1249 KEGG_Gene eco:b1257 http://www.genome.jp/dbget-bin/www_bget?eco:b1257 OMA QHITETQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QHITETQ PSORT swissprot:YCIE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCIE_ECOLI PSORT-B swissprot:YCIE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCIE_ECOLI PSORT2 swissprot:YCIE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCIE_ECOLI Pfam PF05974 http://pfam.xfam.org/family/PF05974 Phobius swissprot:YCIE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCIE_ECOLI ProteinModelPortal P21363 http://www.proteinmodelportal.org/query/uniprot/P21363 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3058546 http://www.ncbi.nlm.nih.gov/pubmed/3058546 PubMed 8455549 http://www.ncbi.nlm.nih.gov/pubmed/8455549 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415773 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415773 RefSeq WP_001079505 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001079505 SMR P21363 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P21363 STRING 511145.b1257 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1257&targetmode=cogs SUPFAM SSF47240 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47240 UniProtKB YCIE_ECOLI http://www.uniprot.org/uniprot/YCIE_ECOLI UniProtKB-AC P21363 http://www.uniprot.org/uniprot/P21363 charge swissprot:YCIE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCIE_ECOLI eggNOG COG3685 http://eggnogapi.embl.de/nog_data/html/tree/COG3685 eggNOG ENOG4108N8X http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108N8X epestfind swissprot:YCIE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCIE_ECOLI garnier swissprot:YCIE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCIE_ECOLI helixturnhelix swissprot:YCIE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCIE_ECOLI hmoment swissprot:YCIE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCIE_ECOLI iep swissprot:YCIE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCIE_ECOLI inforesidue swissprot:YCIE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCIE_ECOLI octanol swissprot:YCIE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCIE_ECOLI pepcoil swissprot:YCIE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCIE_ECOLI pepdigest swissprot:YCIE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCIE_ECOLI pepinfo swissprot:YCIE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCIE_ECOLI pepnet swissprot:YCIE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCIE_ECOLI pepstats swissprot:YCIE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCIE_ECOLI pepwheel swissprot:YCIE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCIE_ECOLI pepwindow swissprot:YCIE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCIE_ECOLI sigcleave swissprot:YCIE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCIE_ECOLI ## Database ID URL or Descriptions # AltName DUSA_ECOLI U20-specific dihydrouridine synthase {ECO 0000255|HAMAP-Rule MF_02041, ECO 0000303|PubMed 25902496} # AltName DUSA_ECOLI tRNA-dihydrouridine synthase A {ECO 0000255|HAMAP-Rule MF_02041, ECO 0000303|PubMed 11983710} # BioGrid 4259608 5 # CATALYTIC ACTIVITY DUSA_ECOLI 5,6-dihydrouracil(20) in tRNA + NAD(P)(+) = uracil(20) in tRNA + NAD(P)H. {ECO 0000255|HAMAP-Rule MF_02041, ECO 0000305|PubMed 11983710, ECO 0000305|PubMed 22123979}. # CATALYTIC ACTIVITY DUSA_ECOLI 5,6-dihydrouracil(20a) in tRNA + NAD(P)(+) = uracil(20a) in tRNA + NAD(P)H. {ECO 0000255|HAMAP-Rule MF_02041, ECO 0000305|PubMed 22123979}. # CAUTION The U21 position mentioned in PubMed:11983710 corresponds in fact to U20 with the conventional numbering. {ECO 0000305}. # COFACTOR DUSA_ECOLI Name=FMN; Xref=ChEBI CHEBI 58210; Evidence={ECO 0000255|HAMAP-Rule MF_02041}; # DISRUPTION PHENOTYPE DUSA_ECOLI A dusA dusB dusC triple mutant exhibits a complete lack of 5,6-dihydrouridine modification in cellular tRNA, whereas each single mutant exhibits a partial reduction, compared to wild type (PubMed 11983710). Cells lacking this gene can introduce D modification at neither 20 or 20a in tRNA (PubMed 22123979). {ECO 0000269|PubMed 11983710, ECO 0000269|PubMed 22123979}. # EcoGene EG11932 dusA # FUNCTION DUSA_ECOLI Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs. {ECO 0000255|HAMAP-Rule MF_02041, ECO 0000269|PubMed 11983710, ECO 0000269|PubMed 22123979, ECO 0000305|PubMed 25902496}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000049 tRNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0010181 FMN binding; IEA:UniProtKB-HAMAP. # GO_function GO:0017150 tRNA dihydrouridine synthase activity; IMP:EcoCyc. # GO_function GO:0050660 flavin adenine dinucleotide binding; IEA:InterPro. # GO_function GO:0102264 tRNA-dihydrouridine20 synthase activity; IEA:UniProtKB-EC. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # Gene3D 3.20.20.70 -; 1. # HAMAP MF_02041 DusA_subfam # InterPro IPR001269 tRNA_hU_synthase # InterPro IPR004653 DusA # InterPro IPR013785 Aldolase_TIM # InterPro IPR018517 tRNA_hU_synthase_CS # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # MISCELLANEOUS DusB and DusC together account for about half of the 5,6-dihydrouridine modification observed in wild-type cellular tRNA, and DusA accounts for the other half. These three enzymes seem to act site-specifically on the tRNA D-loop and contain nonredundant catalytic functions in vivo. {ECO:0000269|PubMed 11983710}. # Organism DUSA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11082 PTHR11082 # PATRIC 32123637 VBIEscCol129921_4167 # PIRSF PIRSF006621 Dus # PROSITE PS01136 UPF0034 # Pfam PF01207 Dus # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DUSA_ECOLI tRNA-dihydrouridine(20/20a) synthase {ECO 0000255|HAMAP-Rule MF_02041, ECO 0000305|PubMed 22123979} # RefSeq NP_418473 NC_000913.3 # SIMILARITY Belongs to the Dus family. DusA subfamily. {ECO:0000255|HAMAP-Rule MF_02041}. # TIGRFAMs TIGR00742 yjbN # eggNOG COG0042 LUCA # eggNOG ENOG4105CEH Bacteria BLAST swissprot:DUSA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DUSA_ECOLI BioCyc ECOL316407:JW5950-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5950-MONOMER BioCyc EcoCyc:EG11932-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11932-MONOMER BioCyc MetaCyc:EG11932-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11932-MONOMER COG COG0042 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0042 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.1112352108 http://dx.doi.org/10.1073/pnas.1112352108 DOI 10.1073/pnas.1500161112 http://dx.doi.org/10.1073/pnas.1500161112 DOI 10.1074/jbc.M203208200 http://dx.doi.org/10.1074/jbc.M203208200 DOI 10.1074/mcp.M113.029165 http://dx.doi.org/10.1074/mcp.M113.029165 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.3.1.- {ECO:0000255|HAMAP-Rule:MF_02041, ECO:0000305|PubMed:22123979} http://www.genome.jp/dbget-bin/www_bget?EC:1.3.1.- {ECO:0000255|HAMAP-Rule:MF_02041, ECO:0000305|PubMed:22123979} EC_number EC:1.3.1.91 {ECO:0000255|HAMAP-Rule:MF_02041, ECO:0000305|PubMed:11983710, ECO:0000305|PubMed:22123979} http://www.genome.jp/dbget-bin/www_bget?EC:1.3.1.91 {ECO:0000255|HAMAP-Rule:MF_02041, ECO:0000305|PubMed:11983710, ECO:0000305|PubMed:22123979} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.3.1.- {ECO:0000255|HAMAP-Rule:MF_02041, ECO:0000305|PubMed:22123979} http://enzyme.expasy.org/EC/1.3.1.- {ECO:0000255|HAMAP-Rule:MF_02041, ECO:0000305|PubMed:22123979} ENZYME 1.3.1.91 {ECO:0000255|HAMAP-Rule:MF_02041, ECO:0000305|PubMed:11983710, ECO:0000305|PubMed:22123979} http://enzyme.expasy.org/EC/1.3.1.91 {ECO:0000255|HAMAP-Rule:MF_02041, ECO:0000305|PubMed:11983710, ECO:0000305|PubMed:22123979} EchoBASE EB1876 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1876 EcoGene EG11932 http://www.ecogene.org/geneInfo.php?eg_id=EG11932 EnsemblBacteria AAC77019 http://www.ensemblgenomes.org/id/AAC77019 EnsemblBacteria AAC77019 http://www.ensemblgenomes.org/id/AAC77019 EnsemblBacteria BAE78051 http://www.ensemblgenomes.org/id/BAE78051 EnsemblBacteria BAE78051 http://www.ensemblgenomes.org/id/BAE78051 EnsemblBacteria BAE78051 http://www.ensemblgenomes.org/id/BAE78051 EnsemblBacteria b4049 http://www.ensemblgenomes.org/id/b4049 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000049 GO_function GO:0010181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010181 GO_function GO:0017150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017150 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_function GO:0102264 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0102264 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 948558 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948558 HAMAP MF_02041 http://hamap.expasy.org/unirule/MF_02041 HOGENOM HOG000259834 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000259834&db=HOGENOM6 InParanoid P32695 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32695 IntEnz 1.3.1.- {ECO:0000255|HAMAP-Rule:MF_02041, ECO:0000305|PubMed:22123979} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.3.1.- {ECO:0000255|HAMAP-Rule:MF_02041, ECO:0000305|PubMed:22123979} IntEnz 1.3.1.91 {ECO:0000255|HAMAP-Rule:MF_02041, ECO:0000305|PubMed:11983710, ECO:0000305|PubMed:22123979} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.3.1.91 {ECO:0000255|HAMAP-Rule:MF_02041, ECO:0000305|PubMed:11983710, ECO:0000305|PubMed:22123979} InterPro IPR001269 http://www.ebi.ac.uk/interpro/entry/IPR001269 InterPro IPR004653 http://www.ebi.ac.uk/interpro/entry/IPR004653 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR018517 http://www.ebi.ac.uk/interpro/entry/IPR018517 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW5950 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5950 KEGG_Gene eco:b4049 http://www.genome.jp/dbget-bin/www_bget?eco:b4049 KEGG_Orthology KO:K05539 http://www.genome.jp/dbget-bin/www_bget?KO:K05539 PANTHER PTHR11082 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11082 PROSITE PS01136 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01136 PSORT swissprot:DUSA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DUSA_ECOLI PSORT-B swissprot:DUSA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DUSA_ECOLI PSORT2 swissprot:DUSA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DUSA_ECOLI Pfam PF01207 http://pfam.xfam.org/family/PF01207 Phobius swissprot:DUSA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DUSA_ECOLI ProteinModelPortal P32695 http://www.proteinmodelportal.org/query/uniprot/P32695 PubMed 11983710 http://www.ncbi.nlm.nih.gov/pubmed/11983710 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22123979 http://www.ncbi.nlm.nih.gov/pubmed/22123979 PubMed 23908556 http://www.ncbi.nlm.nih.gov/pubmed/23908556 PubMed 25902496 http://www.ncbi.nlm.nih.gov/pubmed/25902496 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418473 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418473 SMR P32695 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32695 STRING 511145.b4049 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4049&targetmode=cogs STRING COG0042 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0042&targetmode=cogs TIGRFAMs TIGR00742 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00742 UniProtKB DUSA_ECOLI http://www.uniprot.org/uniprot/DUSA_ECOLI UniProtKB-AC P32695 http://www.uniprot.org/uniprot/P32695 charge swissprot:DUSA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DUSA_ECOLI eggNOG COG0042 http://eggnogapi.embl.de/nog_data/html/tree/COG0042 eggNOG ENOG4105CEH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CEH epestfind swissprot:DUSA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DUSA_ECOLI garnier swissprot:DUSA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DUSA_ECOLI helixturnhelix swissprot:DUSA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DUSA_ECOLI hmoment swissprot:DUSA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DUSA_ECOLI iep swissprot:DUSA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DUSA_ECOLI inforesidue swissprot:DUSA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DUSA_ECOLI octanol swissprot:DUSA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DUSA_ECOLI pepcoil swissprot:DUSA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DUSA_ECOLI pepdigest swissprot:DUSA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DUSA_ECOLI pepinfo swissprot:DUSA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DUSA_ECOLI pepnet swissprot:DUSA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DUSA_ECOLI pepstats swissprot:DUSA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DUSA_ECOLI pepwheel swissprot:DUSA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DUSA_ECOLI pepwindow swissprot:DUSA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DUSA_ECOLI sigcleave swissprot:DUSA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DUSA_ECOLI ## Database ID URL or Descriptions # AltName LSRA_ECOLI EGO10A # BioGrid 4260226 15 # EcoGene EG13806 lsrA # FUNCTION LSRA_ECOLI Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Responsible for energy coupling to the transport system (Probable). This protein is essential for aerobic growth. {ECO 0000269|PubMed 15601708, ECO 0000305}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:InterPro. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0042626 ATPase activity, coupled to transmembrane movement of substances; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.300 -; 2. # INDUCTION LSRA_ECOLI In the absence of AI-2, repressed by LsrR. Induced by AI-2, via release of the LsrR repressor. In the absence of glucose, induced by cAMP-CRP by direct binding to the upstream region of the lsr promoter. {ECO 0000269|PubMed 15601708, ECO 0000269|PubMed 15743955}. # IntAct P77257 3 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # InterPro IPR030281 LsrA # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00219 AI-2 transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism LSRA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR24220:SF555 PTHR24220:SF555 # PATRIC 32118322 VBIEscCol129921_1581 # PIR D64905 D64905 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2; 2 # Pfam PF00005 ABC_tran; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LSRA_ECOLI Autoinducer 2 import ATP-binding protein LsrA # RefSeq NP_416030 NC_000913.3 # RefSeq WP_001194860 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. AI-2 autoinducer porter (TC 3.A.1.2.8) family. {ECO 0000305}. # SIMILARITY Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA; 2 # SUBCELLULAR LOCATION LSRA_ECOLI Cell inner membrane {ECO 0000305}; Peripheral membrane protein {ECO 0000305}. # SUBUNIT The complex is composed of two ATP-binding proteins (LsrA), two transmembrane proteins (LsrC and LsrD) and a solute- binding protein (LsrB). {ECO 0000305}. # SUPFAM SSF52540 SSF52540; 2 # TCDB 3.A.1.2 the atp-binding cassette (abc) superfamily # eggNOG COG1129 LUCA # eggNOG ENOG4105C2J Bacteria BLAST swissprot:LSRA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LSRA_ECOLI BioCyc ECOL316407:JW1506-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1506-MONOMER BioCyc EcoCyc:YDEX-MONOMER http://biocyc.org/getid?id=EcoCyc:YDEX-MONOMER BioCyc MetaCyc:YDEX-MONOMER http://biocyc.org/getid?id=MetaCyc:YDEX-MONOMER COG COG1129 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1129 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.187.1.238-248.2005 http://dx.doi.org/10.1128/JB.187.1.238-248.2005 DOI 10.1128/JB.187.6.2066-2076.2005 http://dx.doi.org/10.1128/JB.187.6.2066-2076.2005 EC_number EC:3.6.3.- http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.- EMBL AF089855 http://www.ebi.ac.uk/ena/data/view/AF089855 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.6.3.- http://enzyme.expasy.org/EC/3.6.3.- EchoBASE EB3567 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3567 EcoGene EG13806 http://www.ecogene.org/geneInfo.php?eg_id=EG13806 EnsemblBacteria AAC74586 http://www.ensemblgenomes.org/id/AAC74586 EnsemblBacteria AAC74586 http://www.ensemblgenomes.org/id/AAC74586 EnsemblBacteria BAA15200 http://www.ensemblgenomes.org/id/BAA15200 EnsemblBacteria BAA15200 http://www.ensemblgenomes.org/id/BAA15200 EnsemblBacteria BAA15200 http://www.ensemblgenomes.org/id/BAA15200 EnsemblBacteria b1513 http://www.ensemblgenomes.org/id/b1513 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0042626 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042626 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945680 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945680 InParanoid P77257 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77257 IntAct P77257 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77257* IntEnz 3.6.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3 InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR030281 http://www.ebi.ac.uk/interpro/entry/IPR030281 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1506 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1506 KEGG_Gene eco:b1513 http://www.genome.jp/dbget-bin/www_bget?eco:b1513 KEGG_Orthology KO:K10558 http://www.genome.jp/dbget-bin/www_bget?KO:K10558 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA QEPMLFP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QEPMLFP PANTHER PTHR24220:SF555 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24220:SF555 PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:LSRA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LSRA_ECOLI PSORT-B swissprot:LSRA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LSRA_ECOLI PSORT2 swissprot:LSRA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LSRA_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Phobius swissprot:LSRA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LSRA_ECOLI PhylomeDB P77257 http://phylomedb.org/?seqid=P77257 ProteinModelPortal P77257 http://www.proteinmodelportal.org/query/uniprot/P77257 PubMed 15601708 http://www.ncbi.nlm.nih.gov/pubmed/15601708 PubMed 15743955 http://www.ncbi.nlm.nih.gov/pubmed/15743955 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416030 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416030 RefSeq WP_001194860 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001194860 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P77257 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77257 STRING 511145.b1513 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1513&targetmode=cogs STRING COG1129 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1129&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.2 http://www.tcdb.org/search/result.php?tc=3.A.1.2 UniProtKB LSRA_ECOLI http://www.uniprot.org/uniprot/LSRA_ECOLI UniProtKB-AC P77257 http://www.uniprot.org/uniprot/P77257 charge swissprot:LSRA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LSRA_ECOLI eggNOG COG1129 http://eggnogapi.embl.de/nog_data/html/tree/COG1129 eggNOG ENOG4105C2J http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C2J epestfind swissprot:LSRA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LSRA_ECOLI garnier swissprot:LSRA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LSRA_ECOLI helixturnhelix swissprot:LSRA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LSRA_ECOLI hmoment swissprot:LSRA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LSRA_ECOLI iep swissprot:LSRA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LSRA_ECOLI inforesidue swissprot:LSRA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LSRA_ECOLI octanol swissprot:LSRA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LSRA_ECOLI pepcoil swissprot:LSRA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LSRA_ECOLI pepdigest swissprot:LSRA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LSRA_ECOLI pepinfo swissprot:LSRA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LSRA_ECOLI pepnet swissprot:LSRA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LSRA_ECOLI pepstats swissprot:LSRA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LSRA_ECOLI pepwheel swissprot:LSRA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LSRA_ECOLI pepwindow swissprot:LSRA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LSRA_ECOLI sigcleave swissprot:LSRA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LSRA_ECOLI ## Database ID URL or Descriptions # AltName GYRB_ECOLI Type IIA topoisomerase subunit GyrB # BRENDA 5.99.1 2026 # BioGrid 4259537 154 # CATALYTIC ACTIVITY GYRB_ECOLI ATP-dependent breakage, passage and rejoining of double-stranded DNA. {ECO 0000255|HAMAP-Rule MF_01898, ECO 0000269|PubMed 12051842, ECO 0000269|PubMed 12051843, ECO 0000269|PubMed 18642932, ECO 0000269|PubMed 186775, ECO 0000269|PubMed 19965760, ECO 0000269|PubMed 20675723, ECO 0000269|PubMed 22731783}. # COFACTOR GYRB_ECOLI Name=K(+); Xref=ChEBI CHEBI 29103; Evidence={ECO 0000269|PubMed 25849408}; Note=Binds one K(+) per subunit which interacts with the alpha- phosphate of ATP analog and stimulates ATPase activity of the N- terminal fragment; Na(+) or water bind less well (PubMed 25849408). {ECO 0000269|PubMed 25849408}; # COFACTOR GYRB_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_01898, ECO 0000269|PubMed 12051843, ECO 0000269|PubMed 18642932}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000255|HAMAP-Rule MF_01898, ECO 0000269|PubMed 12051843, ECO 0000269|PubMed 18642932}; Name=Ca(2+); Xref=ChEBI CHEBI 29108; Evidence={ECO 0000255|HAMAP-Rule MF_01898, ECO 0000269|PubMed 12051843, ECO 0000269|PubMed 18642932}; Note=Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+) (PubMed 12051843, PubMed 18642932). {ECO 0000255|HAMAP-Rule MF_01898, ECO 0000269|PubMed 12051843, ECO 0000269|PubMed 18642932}; # COFACTOR GYRB_ECOLI Name=Na(+); Xref=ChEBI CHEBI 29101; Evidence={ECO 0000269|PubMed 25849408}; Note=Binds one Na(+) per subunit, with 4 ligands provided by water; may be able to bind K(+), the functional significance of this ion is unclear (PubMed 25849408). {ECO 0000269|PubMed 25849408}; # DOMAIN GYRB_ECOLI Consists of 3 domains; the ATPase domain (residues 1-220), the transducer domain (221-392) and the toprim domain (393-804) (PubMed 1646964, PubMed 10734094). ATP-binding is cooperative, and both subunits must be wild-type at residue 103 for supercoiling to occur (PubMed 8621650). Non-hydrolyzable ATP analogs (and ATP- binding) induce dimerization and enhance ATPase activity (PubMed 10734094, PubMed 9657678). ATP hydrolysis induces domain shifts that are probably part of the mechanism of DNA cleavage and rejoining (PubMed 25202966). {ECO 0000269|PubMed 10734094, ECO 0000269|PubMed 1646964, ECO 0000269|PubMed 8621650, ECO 0000305|PubMed 25202966, ECO 0000305|PubMed 9657678}. # DrugBank DB00817 Rosoxacin # ENZYME REGULATION GYRB_ECOLI Gyrase is the target of many classes of inhibitors, including coumarins, cyclothialidines, pyrrolopyrimidines, pyrazolthiazoles and (fluoro)quinolones. Coumarins bind to GyrB and are competitive inhibitors of its ATPase activity (PubMed 7811004). Cyclothialidines also bind GyrB and are ATPase competitive inhibitors; they seem to act differently from coumarins (PubMed 7811004, PubMed 8635474). Pyrrolopyrimidines inhibit both GyrB and its paralog in topoisomerase 4 (parE) (PubMed 23294697, PubMed 23352267, PubMed 24386374). Pyrazolthiazoles also inhibit the ATPase activity of GyrB (PubMed 20356737). Quinolones bind GyrA when the enzyme is complexed with DNA and trap the enzyme in a covalent reaction intermediate with DNA (PubMed 3031051, PubMed 12051842, PubMed 337300). Acriflavine inhibits DNA supercoiling and DNA- stimulated ATPase activity (PubMed 9148951). DNA supercoiling activity is protected from fluoroquinolone inhibition by QnrB4; QnrB4 has no effect on supercoiling activity alone (PubMed 19060136). {ECO 0000269|PubMed 19060136, ECO 0000269|PubMed 20356737, ECO 0000269|PubMed 23294697, ECO 0000269|PubMed 23352267, ECO 0000269|PubMed 24386374, ECO 0000269|PubMed 3031051, ECO 0000269|PubMed 337300, ECO 0000269|PubMed 7811004, ECO 0000269|PubMed 8635474, ECO 0000269|PubMed 9148951, ECO 0000305|PubMed 12051842}. # EcoGene EG10424 gyrB # FUNCTION GYRB_ECOLI DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner to maintain chromosomes in an underwound state (PubMed 186775, PubMed 3031051, PubMed 1323022, PubMed 8248233, PubMed 7811004, PubMed 8621650, PubMed 9657678, PubMed 12051842, PubMed 12051843, PubMed 18642932, PubMed 19060136, PubMed 19965760, PubMed 22457353, PubMed 23294697, PubMed 20356737, PubMed 20675723, PubMed 23352267, PubMed 24386374, PubMed 25202966, PubMed 25849408). This makes better substrates for topoisomerase 4 (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli (PubMed 9334322). Gyrase catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes (PubMed 22457352). Relaxes negatively supercoiled DNA in an ATP-independent manner (PubMed 337300). E.coli gyrase has higher supercoiling activity than other characterized bacterial gyrases; at comparable concentrations E.coli gyrase introduces more supercoils faster than M.tuberculosis gyrase, while M.tuberculosis gyrase has higher decatenation than supercoiling activity compared to E.coli (PubMed 22457352). E.coli makes 15% more negative supercoils in pBR322 plasmid DNA than S.typhimurium; the S.typhimurium GyrB subunit is toxic in E.coli, while the E.coli copy can be expressed in S.typhimurium even though the 2 subunits have 777/804 residues identical (PubMed 17400739). The enzymatic differences between E.coli gyrase and topoisomerase IV are largely due to the GyrA C- terminal domain (approximately residues 524-841) and specifically the GyrA-box (PubMed 8962066, PubMed 16332690). {ECO 0000269|PubMed 12051842, ECO 0000269|PubMed 12051843, ECO 0000269|PubMed 1323022, ECO 0000269|PubMed 16332690, ECO 0000269|PubMed 17400739, ECO 0000269|PubMed 18642932, ECO 0000269|PubMed 186775, ECO 0000269|PubMed 19060136, ECO 0000269|PubMed 19965760, ECO 0000269|PubMed 20356737, ECO 0000269|PubMed 20675723, ECO 0000269|PubMed 22457352, ECO 0000269|PubMed 22457353, ECO 0000269|PubMed 23294697, ECO 0000269|PubMed 23352267, ECO 0000269|PubMed 24386374, ECO 0000269|PubMed 25202966, ECO 0000269|PubMed 25849408, ECO 0000269|PubMed 3031051, ECO 0000269|PubMed 337300, ECO 0000269|PubMed 7811004, ECO 0000269|PubMed 8248233, ECO 0000269|PubMed 8621650, ECO 0000269|PubMed 8962066, ECO 0000269|PubMed 9148951, ECO 0000269|PubMed 9334322, ECO 0000269|PubMed 9657678}. # GO_component GO:0005694 chromosome; IEA:InterPro. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0009295 nucleoid; IBA:GO_Central. # GO_component GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing); IDA:EcoliWiki. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0003677 DNA binding; IDA:EcoliWiki. # GO_function GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity; IDA:EcoliWiki. # GO_function GO:0005524 ATP binding; IDA:EcoliWiki. # GO_function GO:0008094 DNA-dependent ATPase activity; IDA:EcoliWiki. # GO_function GO:0034335 DNA supercoiling activity; IDA:UniProtKB. # GO_process GO:0006265 DNA topological change; IMP:EcoliWiki. # GO_process GO:0006268 DNA unwinding involved in DNA replication; IBA:GO_Central. # GO_process GO:0006351 transcription, DNA-templated; IMP:EcoliWiki. # GO_process GO:0007059 chromosome segregation; IBA:GO_Central. # GO_process GO:0042493 response to drug; IDA:EcoliWiki. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005694 chromosome # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0007059 chromosome segregation # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0051276 chromosome organization # Gene3D 3.30.230.10 -; 1. # Gene3D 3.30.565.10 -; 1. # Gene3D 3.40.50.670 -; 2. # HAMAP MF_01898 GyrB # INTERACTION GYRB_ECOLI P0AES4 gyrA; NbExp=5; IntAct=EBI-541911, EBI-547129; # IntAct P0AES6 18 # InterPro IPR001241 Topo_IIA # InterPro IPR002288 DNA_gyrase_B_C # InterPro IPR003594 HATPase_C # InterPro IPR006171 Toprim_domain # InterPro IPR011557 GyrB # InterPro IPR013506 Topo_IIA_bsu_dom2 # InterPro IPR013759 Topo_IIA_cen_dom # InterPro IPR013760 Topo_IIA-like_dom # InterPro IPR014721 Ribosomal_S5_D2-typ_fold_subgr # InterPro IPR018522 TopoIIA_CS # InterPro IPR020568 Ribosomal_S5_D2-typ_fold # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03032 DNA replication proteins # KEGG_Brite ko03400 DNA repair and recombination proteins # MISCELLANEOUS GYRB_ECOLI When the enzyme transiently cleaves DNA a phosphotyrosine bond is formed between GyrA and DNA in an ATP- independent manner (PubMed 3031051). In the presence of quinolones this intermediate can be trapped and is used as an indicator of drug toxicity (PubMed 12051842). {ECO 0000269|PubMed 3031051, ECO 0000305|PubMed 12051842}. # Organism GYRB_ECOLI Escherichia coli (strain K12) # PATRIC 32122895 VBIEscCol129921_3823 # PDB 1AJ6 X-ray; 2.30 A; A=2-220 # PDB 1EI1 X-ray; 2.30 A; A/B=2-392 # PDB 1KZN X-ray; 2.30 A; A=15-219 # PDB 3G7E X-ray; 2.20 A; A=15-217 # PDB 3NUH X-ray; 3.10 A; B=389-804 # PDB 4DUH X-ray; 1.50 A; A/B=1-220 # PDB 4HYP X-ray; 2.60 A; A/B/C/D=15-220 # PDB 4KFG X-ray; 1.60 A; A/B=15-220 # PDB 4PRV X-ray; 2.00 A; A=2-392 # PDB 4PRX X-ray; 1.80 A; A=2-392 # PDB 4PU9 X-ray; 2.40 A; A=2-392 # PDB 4WUB X-ray; 1.75 A; A=2-393 # PDB 4WUC X-ray; 1.90 A; A=2-393 # PDB 4WUD X-ray; 1.95 A; A=2-393 # PDB 4XTJ X-ray; 1.92 A; A=2-392 # PDB 4ZVI X-ray; 2.20 A; A=16-392 # PDB 5L3J X-ray; 2.83 A; A=15-392 # PIR D65172 ISECTB # PRINTS PR00418 TPI2FAMILY # PROSITE PS00177 TOPOISOMERASE_II # PROSITE PS50880 TOPRIM # Pfam PF00204 DNA_gyraseB # Pfam PF00986 DNA_gyraseB_C # Pfam PF01751 Toprim # Pfam PF02518 HATPase_c # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DNA gyrase subunit B {ECO:0000255|HAMAP-Rule MF_01898} # RefSeq WP_000072067 NZ_LN832404.1 # RefSeq YP_026241 NC_000913.3 # SIMILARITY Belongs to the type II topoisomerase family. {ECO:0000255|HAMAP-Rule MF_01898}. # SIMILARITY Contains 1 Toprim domain. {ECO:0000255|HAMAP- Rule MF_01898}. # SMART SM00387 HATPase_c # SMART SM00433 TOP2c # SUBCELLULAR LOCATION GYRB_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_01898}. # SUBUNIT GYRB_ECOLI Heterotetramer, composed of two GyrA and two GyrB chains (PubMed 9148951, PubMed 12051842). In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with the DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis (PubMed 12051843, PubMed 18642932, PubMed 20675723, PubMed 19965760). {ECO 0000255|HAMAP- Rule MF_01898, ECO 0000269|PubMed 12051842, ECO 0000269|PubMed 12051843, ECO 0000269|PubMed 18642932, ECO 0000269|PubMed 19965760, ECO 0000269|PubMed 20675723, ECO 0000269|PubMed 9148951}. # SUPFAM SSF54211 SSF54211 # SUPFAM SSF55874 SSF55874 # SUPFAM SSF56719 SSF56719; 2 # TIGRFAMs TIGR01059 gyrB # eggNOG COG0187 LUCA # eggNOG ENOG4105C7D Bacteria BLAST swissprot:GYRB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GYRB_ECOLI BioCyc ECOL316407:JW5625-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5625-MONOMER BioCyc EcoCyc:EG10424-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10424-MONOMER BioCyc MetaCyc:EG10424-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10424-MONOMER COG COG0187 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0187 DIP DIP-48005N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48005N DOI 10.1002/(SICI)1097-0134(199705)28:1<41::AID-PROT4>3.3.CO http://dx.doi.org/10.1002/(SICI)1097-0134(199705)28:1<41::AID-PROT4>3.3.CO DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1007/BF00331012 http://dx.doi.org/10.1007/BF00331012 DOI 10.1016/S0022-2836(02)00048-7 http://dx.doi.org/10.1016/S0022-2836(02)00048-7 DOI 10.1016/S0022-2836(02)00049-9 http://dx.doi.org/10.1016/S0022-2836(02)00049-9 DOI 10.1016/j.bmcl.2010.03.052 http://dx.doi.org/10.1016/j.bmcl.2010.03.052 DOI 10.1016/j.bmcl.2012.11.032 http://dx.doi.org/10.1016/j.bmcl.2012.11.032 DOI 10.1016/j.bmcl.2012.11.073 http://dx.doi.org/10.1016/j.bmcl.2012.11.073 DOI 10.1021/bi0159837 http://dx.doi.org/10.1021/bi0159837 DOI 10.1021/bi800480j http://dx.doi.org/10.1021/bi800480j DOI 10.1021/bi970294+ http://dx.doi.org/10.1021/bi970294+ DOI 10.1021/bi9801309 http://dx.doi.org/10.1021/bi9801309 DOI 10.1021/jm300395d http://dx.doi.org/10.1021/jm300395d DOI 10.1038/351624a0 http://dx.doi.org/10.1038/351624a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.73.11.3872 http://dx.doi.org/10.1073/pnas.73.11.3872 DOI 10.1073/pnas.74.11.4772 http://dx.doi.org/10.1073/pnas.74.11.4772 DOI 10.1073/pnas.90.23.11232 http://dx.doi.org/10.1073/pnas.90.23.11232 DOI 10.1073/pnas.93.25.14416 http://dx.doi.org/10.1073/pnas.93.25.14416 DOI 10.1074/jbc.271.16.9723 http://dx.doi.org/10.1074/jbc.271.16.9723 DOI 10.1074/jbc.272.20.13302 http://dx.doi.org/10.1074/jbc.272.20.13302 DOI 10.1074/jbc.275.13.9468 http://dx.doi.org/10.1074/jbc.275.13.9468 DOI 10.1074/jbc.M112.345678 http://dx.doi.org/10.1074/jbc.M112.345678 DOI 10.1074/jbc.M112.345736 http://dx.doi.org/10.1074/jbc.M112.345736 DOI 10.1074/jbc.M511160200 http://dx.doi.org/10.1074/jbc.M511160200 DOI 10.1093/nar/12.16.6389 http://dx.doi.org/10.1093/nar/12.16.6389 DOI 10.1093/nar/15.2.771 http://dx.doi.org/10.1093/nar/15.2.771 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1093/nar/gkq665 http://dx.doi.org/10.1093/nar/gkq665 DOI 10.1101/gad.11.19.2580 http://dx.doi.org/10.1101/gad.11.19.2580 DOI 10.1107/S1399004715002916 http://dx.doi.org/10.1107/S1399004715002916 DOI 10.1111/j.1365-2958.1992.tb00886.x http://dx.doi.org/10.1111/j.1365-2958.1992.tb00886.x DOI 10.1126/science.1179123 http://dx.doi.org/10.1126/science.1179123 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AAC.35.8.1647 http://dx.doi.org/10.1128/AAC.35.8.1647 DOI 10.1128/AAC.38.9.1966 http://dx.doi.org/10.1128/AAC.38.9.1966 DOI 10.1128/JB.00083-07 http://dx.doi.org/10.1128/JB.00083-07 DOI 10.1128/JB.01205-08 http://dx.doi.org/10.1128/JB.01205-08 DOI 10.1371/journal.pone.0084409 http://dx.doi.org/10.1371/journal.pone.0084409 DOI 10.1371/journal.pone.0107289 http://dx.doi.org/10.1371/journal.pone.0107289 DrugBank DB00817 http://www.drugbank.ca/drugs/DB00817 EC_number EC:5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_01898, ECO:0000269|PubMed:12051842, ECO:0000269|PubMed:12051843, ECO:0000269|PubMed:18642932, ECO:0000269|PubMed:186775, ECO:0000269|PubMed:19965760} http://www.genome.jp/dbget-bin/www_bget?EC:5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_01898, ECO:0000269|PubMed:12051842, ECO:0000269|PubMed:12051843, ECO:0000269|PubMed:18642932, ECO:0000269|PubMed:186775, ECO:0000269|PubMed:19965760} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D87842 http://www.ebi.ac.uk/ena/data/view/D87842 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M15548 http://www.ebi.ac.uk/ena/data/view/M15548 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X04341 http://www.ebi.ac.uk/ena/data/view/X04341 ENZYME 5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_01898, ECO:0000269|PubMed:12051842, ECO:0000269|PubMed:12051843, ECO:0000269|PubMed:18642932, ECO:0000269|PubMed:186775, ECO:0000269|PubMed:19965760} http://enzyme.expasy.org/EC/5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_01898, ECO:0000269|PubMed:12051842, ECO:0000269|PubMed:12051843, ECO:0000269|PubMed:18642932, ECO:0000269|PubMed:186775, ECO:0000269|PubMed:19965760} EchoBASE EB0419 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0419 EcoGene EG10424 http://www.ecogene.org/geneInfo.php?eg_id=EG10424 EnsemblBacteria AAT48201 http://www.ensemblgenomes.org/id/AAT48201 EnsemblBacteria AAT48201 http://www.ensemblgenomes.org/id/AAT48201 EnsemblBacteria BAE77595 http://www.ensemblgenomes.org/id/BAE77595 EnsemblBacteria BAE77595 http://www.ensemblgenomes.org/id/BAE77595 EnsemblBacteria BAE77595 http://www.ensemblgenomes.org/id/BAE77595 EnsemblBacteria b3699 http://www.ensemblgenomes.org/id/b3699 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005694 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005694 GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0009295 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009295 GO_component GO:0009330 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009330 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003918 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003918 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008094 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008094 GO_function GO:0034335 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034335 GO_process GO:0006265 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006265 GO_process GO:0006268 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006268 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0007059 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007059 GO_process GO:0042493 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005694 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005694 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0007059 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007059 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0051276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051276 Gene3D 3.30.230.10 http://www.cathdb.info/version/latest/superfamily/3.30.230.10 Gene3D 3.30.565.10 http://www.cathdb.info/version/latest/superfamily/3.30.565.10 Gene3D 3.40.50.670 http://www.cathdb.info/version/latest/superfamily/3.40.50.670 GeneID 948211 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948211 HAMAP MF_01898 http://hamap.expasy.org/unirule/MF_01898 HOGENOM HOG000075155 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000075155&db=HOGENOM6 InParanoid P0AES6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AES6 IntAct P0AES6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AES6* IntEnz 5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_01898, ECO:0000269|PubMed:12051842, ECO:0000269|PubMed:12051843, ECO:0000269|PubMed:18642932, ECO:0000269|PubMed:186775, ECO:0000269|PubMed:19965760} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_01898, ECO:0000269|PubMed:12051842, ECO:0000269|PubMed:12051843, ECO:0000269|PubMed:18642932, ECO:0000269|PubMed:186775, ECO:0000269|PubMed:19965760} InterPro IPR001241 http://www.ebi.ac.uk/interpro/entry/IPR001241 InterPro IPR002288 http://www.ebi.ac.uk/interpro/entry/IPR002288 InterPro IPR003594 http://www.ebi.ac.uk/interpro/entry/IPR003594 InterPro IPR006171 http://www.ebi.ac.uk/interpro/entry/IPR006171 InterPro IPR011557 http://www.ebi.ac.uk/interpro/entry/IPR011557 InterPro IPR013506 http://www.ebi.ac.uk/interpro/entry/IPR013506 InterPro IPR013759 http://www.ebi.ac.uk/interpro/entry/IPR013759 InterPro IPR013760 http://www.ebi.ac.uk/interpro/entry/IPR013760 InterPro IPR014721 http://www.ebi.ac.uk/interpro/entry/IPR014721 InterPro IPR018522 http://www.ebi.ac.uk/interpro/entry/IPR018522 InterPro IPR020568 http://www.ebi.ac.uk/interpro/entry/IPR020568 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03032 http://www.genome.jp/dbget-bin/www_bget?ko03032 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW5625 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5625 KEGG_Gene eco:b3699 http://www.genome.jp/dbget-bin/www_bget?eco:b3699 KEGG_Orthology KO:K02470 http://www.genome.jp/dbget-bin/www_bget?KO:K02470 OMA IKNMITA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IKNMITA PDB 1AJ6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1AJ6 PDB 1EI1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1EI1 PDB 1KZN http://www.ebi.ac.uk/pdbe-srv/view/entry/1KZN PDB 3G7E http://www.ebi.ac.uk/pdbe-srv/view/entry/3G7E PDB 3NUH http://www.ebi.ac.uk/pdbe-srv/view/entry/3NUH PDB 4DUH http://www.ebi.ac.uk/pdbe-srv/view/entry/4DUH PDB 4HYP http://www.ebi.ac.uk/pdbe-srv/view/entry/4HYP PDB 4KFG http://www.ebi.ac.uk/pdbe-srv/view/entry/4KFG PDB 4PRV http://www.ebi.ac.uk/pdbe-srv/view/entry/4PRV PDB 4PRX http://www.ebi.ac.uk/pdbe-srv/view/entry/4PRX PDB 4PU9 http://www.ebi.ac.uk/pdbe-srv/view/entry/4PU9 PDB 4WUB http://www.ebi.ac.uk/pdbe-srv/view/entry/4WUB PDB 4WUC http://www.ebi.ac.uk/pdbe-srv/view/entry/4WUC PDB 4WUD http://www.ebi.ac.uk/pdbe-srv/view/entry/4WUD PDB 4XTJ http://www.ebi.ac.uk/pdbe-srv/view/entry/4XTJ PDB 4ZVI http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZVI PDB 5L3J http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3J PDBsum 1AJ6 http://www.ebi.ac.uk/pdbsum/1AJ6 PDBsum 1EI1 http://www.ebi.ac.uk/pdbsum/1EI1 PDBsum 1KZN http://www.ebi.ac.uk/pdbsum/1KZN PDBsum 3G7E http://www.ebi.ac.uk/pdbsum/3G7E PDBsum 3NUH http://www.ebi.ac.uk/pdbsum/3NUH PDBsum 4DUH http://www.ebi.ac.uk/pdbsum/4DUH PDBsum 4HYP http://www.ebi.ac.uk/pdbsum/4HYP PDBsum 4KFG http://www.ebi.ac.uk/pdbsum/4KFG PDBsum 4PRV http://www.ebi.ac.uk/pdbsum/4PRV PDBsum 4PRX http://www.ebi.ac.uk/pdbsum/4PRX PDBsum 4PU9 http://www.ebi.ac.uk/pdbsum/4PU9 PDBsum 4WUB http://www.ebi.ac.uk/pdbsum/4WUB PDBsum 4WUC http://www.ebi.ac.uk/pdbsum/4WUC PDBsum 4WUD http://www.ebi.ac.uk/pdbsum/4WUD PDBsum 4XTJ http://www.ebi.ac.uk/pdbsum/4XTJ PDBsum 4ZVI http://www.ebi.ac.uk/pdbsum/4ZVI PDBsum 5L3J http://www.ebi.ac.uk/pdbsum/5L3J PRINTS PR00418 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00418 PROSITE PS00177 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00177 PROSITE PS50880 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50880 PSORT swissprot:GYRB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GYRB_ECOLI PSORT-B swissprot:GYRB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GYRB_ECOLI PSORT2 swissprot:GYRB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GYRB_ECOLI Pfam PF00204 http://pfam.xfam.org/family/PF00204 Pfam PF00986 http://pfam.xfam.org/family/PF00986 Pfam PF01751 http://pfam.xfam.org/family/PF01751 Pfam PF02518 http://pfam.xfam.org/family/PF02518 Phobius swissprot:GYRB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GYRB_ECOLI PhylomeDB P0AES6 http://phylomedb.org/?seqid=P0AES6 ProteinModelPortal P0AES6 http://www.proteinmodelportal.org/query/uniprot/P0AES6 PubMed 10734094 http://www.ncbi.nlm.nih.gov/pubmed/10734094 PubMed 12044152 http://www.ncbi.nlm.nih.gov/pubmed/12044152 PubMed 12051842 http://www.ncbi.nlm.nih.gov/pubmed/12051842 PubMed 12051843 http://www.ncbi.nlm.nih.gov/pubmed/12051843 PubMed 1323022 http://www.ncbi.nlm.nih.gov/pubmed/1323022 PubMed 16332690 http://www.ncbi.nlm.nih.gov/pubmed/16332690 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 1646964 http://www.ncbi.nlm.nih.gov/pubmed/1646964 PubMed 1656869 http://www.ncbi.nlm.nih.gov/pubmed/1656869 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17400739 http://www.ncbi.nlm.nih.gov/pubmed/17400739 PubMed 1846808 http://www.ncbi.nlm.nih.gov/pubmed/1846808 PubMed 18642932 http://www.ncbi.nlm.nih.gov/pubmed/18642932 PubMed 186775 http://www.ncbi.nlm.nih.gov/pubmed/186775 PubMed 19060136 http://www.ncbi.nlm.nih.gov/pubmed/19060136 PubMed 19965760 http://www.ncbi.nlm.nih.gov/pubmed/19965760 PubMed 20356737 http://www.ncbi.nlm.nih.gov/pubmed/20356737 PubMed 20675723 http://www.ncbi.nlm.nih.gov/pubmed/20675723 PubMed 2174443 http://www.ncbi.nlm.nih.gov/pubmed/2174443 PubMed 22457352 http://www.ncbi.nlm.nih.gov/pubmed/22457352 PubMed 22457353 http://www.ncbi.nlm.nih.gov/pubmed/22457353 PubMed 22731783 http://www.ncbi.nlm.nih.gov/pubmed/22731783 PubMed 23294697 http://www.ncbi.nlm.nih.gov/pubmed/23294697 PubMed 23352267 http://www.ncbi.nlm.nih.gov/pubmed/23352267 PubMed 24386374 http://www.ncbi.nlm.nih.gov/pubmed/24386374 PubMed 25202966 http://www.ncbi.nlm.nih.gov/pubmed/25202966 PubMed 25849408 http://www.ncbi.nlm.nih.gov/pubmed/25849408 PubMed 3020376 http://www.ncbi.nlm.nih.gov/pubmed/3020376 PubMed 3029031 http://www.ncbi.nlm.nih.gov/pubmed/3029031 PubMed 3029692 http://www.ncbi.nlm.nih.gov/pubmed/3029692 PubMed 3031051 http://www.ncbi.nlm.nih.gov/pubmed/3031051 PubMed 337300 http://www.ncbi.nlm.nih.gov/pubmed/337300 PubMed 6089112 http://www.ncbi.nlm.nih.gov/pubmed/6089112 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 7811004 http://www.ncbi.nlm.nih.gov/pubmed/7811004 PubMed 8248233 http://www.ncbi.nlm.nih.gov/pubmed/8248233 PubMed 8621650 http://www.ncbi.nlm.nih.gov/pubmed/8621650 PubMed 8635474 http://www.ncbi.nlm.nih.gov/pubmed/8635474 PubMed 8962066 http://www.ncbi.nlm.nih.gov/pubmed/8962066 PubMed 9144789 http://www.ncbi.nlm.nih.gov/pubmed/9144789 PubMed 9148951 http://www.ncbi.nlm.nih.gov/pubmed/9148951 PubMed 9245398 http://www.ncbi.nlm.nih.gov/pubmed/9245398 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9334322 http://www.ncbi.nlm.nih.gov/pubmed/9334322 PubMed 9657678 http://www.ncbi.nlm.nih.gov/pubmed/9657678 RefSeq WP_000072067 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000072067 RefSeq YP_026241 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026241 SMART SM00387 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00387 SMART SM00433 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00433 SMR P0AES6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AES6 STRING 511145.b3699 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3699&targetmode=cogs STRING COG0187 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0187&targetmode=cogs SUPFAM SSF54211 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54211 SUPFAM SSF55874 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55874 SUPFAM SSF56719 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56719 TIGRFAMs TIGR01059 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01059 UniProtKB GYRB_ECOLI http://www.uniprot.org/uniprot/GYRB_ECOLI UniProtKB-AC P0AES6 http://www.uniprot.org/uniprot/P0AES6 charge swissprot:GYRB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GYRB_ECOLI eggNOG COG0187 http://eggnogapi.embl.de/nog_data/html/tree/COG0187 eggNOG ENOG4105C7D http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C7D epestfind swissprot:GYRB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GYRB_ECOLI garnier swissprot:GYRB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GYRB_ECOLI helixturnhelix swissprot:GYRB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GYRB_ECOLI hmoment swissprot:GYRB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GYRB_ECOLI iep swissprot:GYRB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GYRB_ECOLI inforesidue swissprot:GYRB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GYRB_ECOLI octanol swissprot:GYRB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GYRB_ECOLI pepcoil swissprot:GYRB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GYRB_ECOLI pepdigest swissprot:GYRB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GYRB_ECOLI pepinfo swissprot:GYRB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GYRB_ECOLI pepnet swissprot:GYRB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GYRB_ECOLI pepstats swissprot:GYRB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GYRB_ECOLI pepwheel swissprot:GYRB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GYRB_ECOLI pepwindow swissprot:GYRB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GYRB_ECOLI sigcleave swissprot:GYRB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GYRB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260077 188 # DISRUPTION PHENOTYPE Cells show increased biofilm formation when glucose is present in the medium. In a continuous-flow system with M9C medium supplemented with glucose, the biofilm had a 240-fold greater biomass, a 2800 fold-greater average thickness and a 16- fold increased surface coverage than the wild-type. {ECO:0000269|PubMed 16597943}. # EcoGene EG14335 bssS # FUNCTION BSSS_ECOLI Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway. {ECO 0000269|PubMed 16597943}. # GO_process GO:1900190 regulation of single-species biofilm formation; IMP:EcoCyc. # GOslim_process GO:0008150 biological_process # INDUCTION After 3 hrs of cold shock. {ECO:0000269|PubMed 14527658}. # IntAct P0AB33 3 # InterPro IPR025730 Biofilm_BssS # Organism BSSS_ECOLI Escherichia coli (strain K12) # PATRIC 32117359 VBIEscCol129921_1102 # PIR A64849 A64849 # Pfam PF13991 BssS # ProDom PD060858 Biofilm_regulator_BssS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BSSS_ECOLI Biofilm regulator BssS # RefSeq NP_415578 NC_000913.3 # RefSeq WP_000414438 NZ_LN832404.1 # eggNOG ENOG4105PVA Bacteria # eggNOG ENOG4111V92 LUCA BLAST swissprot:BSSS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BSSS_ECOLI BioCyc ECOL316407:JW5152-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5152-MONOMER BioCyc EcoCyc:G6557-MONOMER http://biocyc.org/getid?id=EcoCyc:G6557-MONOMER DOI 10.1016/S0923-2508(03)00167-0 http://dx.doi.org/10.1016/S0923-2508(03)00167-0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AEM.72.4.2449-2459.2006 http://dx.doi.org/10.1128/AEM.72.4.2449-2459.2006 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4081 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4081 EcoGene EG14335 http://www.ecogene.org/geneInfo.php?eg_id=EG14335 EnsemblBacteria AAC74144 http://www.ensemblgenomes.org/id/AAC74144 EnsemblBacteria AAC74144 http://www.ensemblgenomes.org/id/AAC74144 EnsemblBacteria BAA35857 http://www.ensemblgenomes.org/id/BAA35857 EnsemblBacteria BAA35857 http://www.ensemblgenomes.org/id/BAA35857 EnsemblBacteria BAA35857 http://www.ensemblgenomes.org/id/BAA35857 EnsemblBacteria b1060 http://www.ensemblgenomes.org/id/b1060 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:1900190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1900190 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 946104 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946104 HOGENOM HOG000119007 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000119007&db=HOGENOM6 IntAct P0AB33 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AB33* InterPro IPR025730 http://www.ebi.ac.uk/interpro/entry/IPR025730 KEGG_Gene ecj:JW5152 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5152 KEGG_Gene eco:b1060 http://www.genome.jp/dbget-bin/www_bget?eco:b1060 KEGG_Orthology KO:K12148 http://www.genome.jp/dbget-bin/www_bget?KO:K12148 OMA YILQAGI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YILQAGI PSORT swissprot:BSSS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BSSS_ECOLI PSORT-B swissprot:BSSS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BSSS_ECOLI PSORT2 swissprot:BSSS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BSSS_ECOLI Pfam PF13991 http://pfam.xfam.org/family/PF13991 Phobius swissprot:BSSS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BSSS_ECOLI ProteinModelPortal P0AB33 http://www.proteinmodelportal.org/query/uniprot/P0AB33 PubMed 14527658 http://www.ncbi.nlm.nih.gov/pubmed/14527658 PubMed 16597943 http://www.ncbi.nlm.nih.gov/pubmed/16597943 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415578 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415578 RefSeq WP_000414438 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000414438 STRING 511145.b1060 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1060&targetmode=cogs UniProtKB BSSS_ECOLI http://www.uniprot.org/uniprot/BSSS_ECOLI UniProtKB-AC P0AB33 http://www.uniprot.org/uniprot/P0AB33 charge swissprot:BSSS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BSSS_ECOLI eggNOG ENOG4105PVA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105PVA eggNOG ENOG4111V92 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111V92 epestfind swissprot:BSSS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BSSS_ECOLI garnier swissprot:BSSS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BSSS_ECOLI helixturnhelix swissprot:BSSS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BSSS_ECOLI hmoment swissprot:BSSS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BSSS_ECOLI iep swissprot:BSSS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BSSS_ECOLI inforesidue swissprot:BSSS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BSSS_ECOLI octanol swissprot:BSSS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BSSS_ECOLI pepcoil swissprot:BSSS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BSSS_ECOLI pepdigest swissprot:BSSS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BSSS_ECOLI pepinfo swissprot:BSSS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BSSS_ECOLI pepnet swissprot:BSSS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BSSS_ECOLI pepstats swissprot:BSSS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BSSS_ECOLI pepwheel swissprot:BSSS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BSSS_ECOLI pepwindow swissprot:BSSS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BSSS_ECOLI sigcleave swissprot:BSSS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BSSS_ECOLI ## Database ID URL or Descriptions # AltName EX1_ECOLI DNA deoxyribophosphodiesterase # BRENDA 3.1.11 2026 # BioGrid 4260414 101 # CATALYTIC ACTIVITY EX1_ECOLI Exonucleolytic cleavage in the 3'- to 5'- direction to yield nucleoside 5'-phosphates. {ECO 0000269|PubMed 18591666, ECO 0000269|PubMed 20018747, ECO 0000269|PubMed 23609540}. # COFACTOR EX1_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 18219121, ECO 0000269|PubMed 18591666, ECO 0000269|PubMed 20018747, ECO 0000269|PubMed 23609540}; Note=Binds 2 Mg(2+) ions per monomer. {ECO 0000269|PubMed 18591666}; # DOMAIN EX1_ECOLI The N-terminal exonuclease domain and the exonuclease C- terminal domain form a central positively charged groove which binds the DNA. {ECO 0000269|PubMed 18591666, ECO 0000269|PubMed 23609540, ECO 0000305|PubMed 11101894, ECO 0000305|PubMed 18219121}. # ENZYME REGULATION Inhibited by 10 mM EDTA. {ECO:0000269|PubMed 23609540}. # EcoGene EG10926 sbcB # FUNCTION EX1_ECOLI Degrades single-stranded DNA (ssDNA) in a highly processive manner (PubMed 23609540). Also functions as a DNA deoxyribophosphodiesterase that releases deoxyribose-phosphate moieties following the cleavage of DNA at an apurinic/apyrimidinic (AP) site by either an AP endonuclease or AP lyase (PubMed 1329027). {ECO 0000269|PubMed 1329027, ECO 0000269|PubMed 23609540}. # GO_function GO:0000175 3'-5'-exoribonuclease activity; IBA:GO_Central. # GO_function GO:0000287 magnesium ion binding; IDA:UniProtKB. # GO_function GO:0003697 single-stranded DNA binding; IDA:UniProtKB. # GO_function GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity; IDA:UniProtKB. # GO_function GO:0008852 exodeoxyribonuclease I activity; IDA:EcoCyc. # GO_function GO:0051575 5'-deoxyribose-5-phosphate lyase activity; IDA:UniProtKB. # GO_process GO:0000738 DNA catabolic process, exonucleolytic; IDA:UniProtKB. # GO_process GO:0006281 DNA repair; IEA:UniProtKB-KW. # GO_process GO:0006308 DNA catabolic process; IDA:EcoCyc. # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004518 nuclease activity # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # Gene3D 3.30.420.10 -; 1. # IntAct P04995 6 # InterPro IPR012337 RNaseH-like_dom # InterPro IPR013520 Exonuclease_RNaseT/DNA_pol3 # InterPro IPR013620 Exonuc_X-T_C # InterPro IPR023607 Exodeoxyribonuclease_I # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko03430 Mismatch repair # Organism EX1_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11046:SF2 PTHR11046:SF2 # PATRIC 32119357 VBIEscCol129921_2088 # PDB 1FXX X-ray; 2.40 A; A=1-475 # PDB 2QXF X-ray; 1.50 A; A=1-475 # PDB 3C94 X-ray; 2.70 A; A=1-475 # PDB 3C95 X-ray; 1.70 A; A=1-475 # PDB 3HL8 X-ray; 1.55 A; A=1-475 # PDB 3HP9 X-ray; 1.60 A; A=1-475 # PDB 4HCB X-ray; 2.00 A; A/B=1-475 # PDB 4HCC X-ray; 2.96 A; A/B=1-475 # PDB 4JRP X-ray; 1.95 A; A/B=1-475 # PDB 4JRQ X-ray; 3.00 A; A/B=1-475 # PDB 4JS4 X-ray; 3.10 A; A/B=1-475 # PDB 4JS5 X-ray; 3.50 A; A/B=1-475 # PIR B64966 NCECX1 # PIRSF PIRSF000977 Exodeoxyribonuclease_I # PROSITE PS51784 EXOI_SH3 # PROSITE PS51785 EXOI_C # Pfam PF00929 RNase_T # Pfam PF08411 Exonuc_X-T_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EX1_ECOLI Exodeoxyribonuclease I # RefSeq NP_416515 NC_000913.3 # SIMILARITY Contains 1 ExoI C-terminal domain. {ECO:0000255|PROSITE-ProRule PRU01121}. # SIMILARITY Contains 1 ExoI SH3-like domain. {ECO:0000255|PROSITE- ProRule PRU01120}. # SIMILARITY Contains 1 exonuclease domain. {ECO 0000255}. # SMART SM00479 EXOIII # SUBUNIT EX1_ECOLI Monomer (PubMed 23609540). Interacts with ssb (via C- terminus); this interaction stimulates the exonuclease activity by recruiting the enzyme to its substrate (PubMed 18591666, PubMed 20018747). {ECO 0000269|PubMed 18591666, ECO 0000269|PubMed 20018747, ECO 0000269|PubMed 23609540}. # SUPFAM SSF53098 SSF53098 # eggNOG COG2925 LUCA # eggNOG ENOG4105CJB Bacteria BLAST swissprot:EX1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EX1_ECOLI BioCyc ECOL316407:JW1993-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1993-MONOMER BioCyc EcoCyc:EG10926-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10926-MONOMER BioCyc MetaCyc:EG10926-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10926-MONOMER COG COG2925 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2925 DIP DIP-10827N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10827N DOI 10.1038/81978 http://dx.doi.org/10.1038/81978 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0800741105 http://dx.doi.org/10.1073/pnas.0800741105 DOI 10.1073/pnas.0909191107 http://dx.doi.org/10.1073/pnas.0909191107 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/nar/20.18.4699 http://dx.doi.org/10.1093/nar/20.18.4699 DOI 10.1093/nar/gkt278 http://dx.doi.org/10.1093/nar/gkt278 DOI 10.1107/S090744490706012X http://dx.doi.org/10.1107/S090744490706012X DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.11.1 {ECO:0000269|PubMed:18591666, ECO:0000269|PubMed:20018747, ECO:0000269|PubMed:23609540} http://www.genome.jp/dbget-bin/www_bget?EC:3.1.11.1 {ECO:0000269|PubMed:18591666, ECO:0000269|PubMed:20018747, ECO:0000269|PubMed:23609540} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J02641 http://www.ebi.ac.uk/ena/data/view/J02641 EMBL U00009 http://www.ebi.ac.uk/ena/data/view/U00009 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.11.1 {ECO:0000269|PubMed:18591666, ECO:0000269|PubMed:20018747, ECO:0000269|PubMed:23609540} http://enzyme.expasy.org/EC/3.1.11.1 {ECO:0000269|PubMed:18591666, ECO:0000269|PubMed:20018747, ECO:0000269|PubMed:23609540} EchoBASE EB0919 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0919 EcoGene EG10926 http://www.ecogene.org/geneInfo.php?eg_id=EG10926 EnsemblBacteria AAC75072 http://www.ensemblgenomes.org/id/AAC75072 EnsemblBacteria AAC75072 http://www.ensemblgenomes.org/id/AAC75072 EnsemblBacteria BAA15839 http://www.ensemblgenomes.org/id/BAA15839 EnsemblBacteria BAA15839 http://www.ensemblgenomes.org/id/BAA15839 EnsemblBacteria BAA15839 http://www.ensemblgenomes.org/id/BAA15839 EnsemblBacteria b2011 http://www.ensemblgenomes.org/id/b2011 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000175 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000175 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0003697 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003697 GO_function GO:0008310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008310 GO_function GO:0008852 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008852 GO_function GO:0051575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051575 GO_process GO:0000738 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000738 GO_process GO:0006281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006281 GO_process GO:0006308 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006308 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 Gene3D 3.30.420.10 http://www.cathdb.info/version/latest/superfamily/3.30.420.10 GeneID 946529 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946529 HOGENOM HOG000276591 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276591&db=HOGENOM6 InParanoid P04995 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P04995 IntAct P04995 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P04995* IntEnz 3.1.11.1 {ECO:0000269|PubMed:18591666, ECO:0000269|PubMed:20018747, ECO:0000269|PubMed:23609540} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.11.1 {ECO:0000269|PubMed:18591666, ECO:0000269|PubMed:20018747, ECO:0000269|PubMed:23609540} InterPro IPR012337 http://www.ebi.ac.uk/interpro/entry/IPR012337 InterPro IPR013520 http://www.ebi.ac.uk/interpro/entry/IPR013520 InterPro IPR013620 http://www.ebi.ac.uk/interpro/entry/IPR013620 InterPro IPR023607 http://www.ebi.ac.uk/interpro/entry/IPR023607 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW1993 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1993 KEGG_Gene eco:b2011 http://www.genome.jp/dbget-bin/www_bget?eco:b2011 KEGG_Orthology KO:K01141 http://www.genome.jp/dbget-bin/www_bget?KO:K01141 KEGG_Pathway ko03430 http://www.genome.jp/kegg-bin/show_pathway?ko03430 MINT MINT-1241098 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1241098 OMA RDRPAQF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RDRPAQF PANTHER PTHR11046:SF2 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11046:SF2 PDB 1FXX http://www.ebi.ac.uk/pdbe-srv/view/entry/1FXX PDB 2QXF http://www.ebi.ac.uk/pdbe-srv/view/entry/2QXF PDB 3C94 http://www.ebi.ac.uk/pdbe-srv/view/entry/3C94 PDB 3C95 http://www.ebi.ac.uk/pdbe-srv/view/entry/3C95 PDB 3HL8 http://www.ebi.ac.uk/pdbe-srv/view/entry/3HL8 PDB 3HP9 http://www.ebi.ac.uk/pdbe-srv/view/entry/3HP9 PDB 4HCB http://www.ebi.ac.uk/pdbe-srv/view/entry/4HCB PDB 4HCC http://www.ebi.ac.uk/pdbe-srv/view/entry/4HCC PDB 4JRP http://www.ebi.ac.uk/pdbe-srv/view/entry/4JRP PDB 4JRQ http://www.ebi.ac.uk/pdbe-srv/view/entry/4JRQ PDB 4JS4 http://www.ebi.ac.uk/pdbe-srv/view/entry/4JS4 PDB 4JS5 http://www.ebi.ac.uk/pdbe-srv/view/entry/4JS5 PDBsum 1FXX http://www.ebi.ac.uk/pdbsum/1FXX PDBsum 2QXF http://www.ebi.ac.uk/pdbsum/2QXF PDBsum 3C94 http://www.ebi.ac.uk/pdbsum/3C94 PDBsum 3C95 http://www.ebi.ac.uk/pdbsum/3C95 PDBsum 3HL8 http://www.ebi.ac.uk/pdbsum/3HL8 PDBsum 3HP9 http://www.ebi.ac.uk/pdbsum/3HP9 PDBsum 4HCB http://www.ebi.ac.uk/pdbsum/4HCB PDBsum 4HCC http://www.ebi.ac.uk/pdbsum/4HCC PDBsum 4JRP http://www.ebi.ac.uk/pdbsum/4JRP PDBsum 4JRQ http://www.ebi.ac.uk/pdbsum/4JRQ PDBsum 4JS4 http://www.ebi.ac.uk/pdbsum/4JS4 PDBsum 4JS5 http://www.ebi.ac.uk/pdbsum/4JS5 PROSITE PS51784 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51784 PROSITE PS51785 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51785 PSORT swissprot:EX1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EX1_ECOLI PSORT-B swissprot:EX1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EX1_ECOLI PSORT2 swissprot:EX1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EX1_ECOLI Pfam PF00929 http://pfam.xfam.org/family/PF00929 Pfam PF08411 http://pfam.xfam.org/family/PF08411 Phobius swissprot:EX1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EX1_ECOLI PhylomeDB P04995 http://phylomedb.org/?seqid=P04995 ProteinModelPortal P04995 http://www.proteinmodelportal.org/query/uniprot/P04995 PubMed 11101894 http://www.ncbi.nlm.nih.gov/pubmed/11101894 PubMed 1329027 http://www.ncbi.nlm.nih.gov/pubmed/1329027 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18219121 http://www.ncbi.nlm.nih.gov/pubmed/18219121 PubMed 18591666 http://www.ncbi.nlm.nih.gov/pubmed/18591666 PubMed 20018747 http://www.ncbi.nlm.nih.gov/pubmed/20018747 PubMed 23609540 http://www.ncbi.nlm.nih.gov/pubmed/23609540 PubMed 3539937 http://www.ncbi.nlm.nih.gov/pubmed/3539937 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416515 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416515 SMART SM00479 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00479 SMR P04995 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P04995 STRING 511145.b2011 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2011&targetmode=cogs STRING COG2925 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2925&targetmode=cogs SUPFAM SSF53098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098 UniProtKB EX1_ECOLI http://www.uniprot.org/uniprot/EX1_ECOLI UniProtKB-AC P04995 http://www.uniprot.org/uniprot/P04995 charge swissprot:EX1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EX1_ECOLI eggNOG COG2925 http://eggnogapi.embl.de/nog_data/html/tree/COG2925 eggNOG ENOG4105CJB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CJB epestfind swissprot:EX1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EX1_ECOLI garnier swissprot:EX1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EX1_ECOLI helixturnhelix swissprot:EX1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EX1_ECOLI hmoment swissprot:EX1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EX1_ECOLI iep swissprot:EX1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EX1_ECOLI inforesidue swissprot:EX1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EX1_ECOLI octanol swissprot:EX1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EX1_ECOLI pepcoil swissprot:EX1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EX1_ECOLI pepdigest swissprot:EX1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EX1_ECOLI pepinfo swissprot:EX1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EX1_ECOLI pepnet swissprot:EX1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EX1_ECOLI pepstats swissprot:EX1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EX1_ECOLI pepwheel swissprot:EX1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EX1_ECOLI pepwindow swissprot:EX1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EX1_ECOLI sigcleave swissprot:EX1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EX1_ECOLI ## Database ID URL or Descriptions # BioGrid 4260465 100 # CDD cd06174 MFS # EcoGene EG12034 setB # FUNCTION SETB_ECOLI Involved in the efflux of sugars. The physiological role may be the detoxification of non-metabolizable sugar analogs. Can transport lactose and glucose. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:EcoliWiki. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015542 sugar efflux transmembrane transporter activity; IDA:EcoliWiki. # GO_process GO:0007059 chromosome segregation; IMP:EcoliWiki. # GO_process GO:0015758 glucose transport; IDA:EcoliWiki. # GO_process GO:0015767 lactose transport; IDA:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0007059 chromosome segregation # InterPro IPR004750 Sugar_efflux # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # KEGG_Brite ko02000 Transporters # Organism SETB_ECOLI Escherichia coli (strain K12) # PATRIC 32119691 VBIEscCol129921_2256 # PIR A64986 A64986 # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SETB_ECOLI Sugar efflux transporter B # RefSeq NP_416675 NC_000913.3 # RefSeq WP_000551980 NZ_LN832404.1 # SIMILARITY Belongs to the major facilitator superfamily. Set transporter family. {ECO 0000305}. # SUBCELLULAR LOCATION SETB_ECOLI Cell inner membrane {ECO 0000305}; Multi- pass membrane protein {ECO 0000305}. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.20 the major facilitator superfamily (mfs) # TIGRFAMs TIGR00899 2A0120 # eggNOG ENOG4105S8Q Bacteria # eggNOG ENOG410XTE9 LUCA BLAST swissprot:SETB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SETB_ECOLI BioCyc ECOL316407:JW2157-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2157-MONOMER BioCyc EcoCyc:B2170-MONOMER http://biocyc.org/getid?id=EcoCyc:B2170-MONOMER BioCyc MetaCyc:B2170-MONOMER http://biocyc.org/getid?id=MetaCyc:B2170-MONOMER COG COG0477 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0477 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1999.01321.x http://dx.doi.org/10.1046/j.1365-2958.1999.01321.x DOI 10.1074/jbc.274.33.22977 http://dx.doi.org/10.1074/jbc.274.33.22977 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1969 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1969 EcoGene EG12034 http://www.ecogene.org/geneInfo.php?eg_id=EG12034 EnsemblBacteria AAC75231 http://www.ensemblgenomes.org/id/AAC75231 EnsemblBacteria AAC75231 http://www.ensemblgenomes.org/id/AAC75231 EnsemblBacteria BAA15979 http://www.ensemblgenomes.org/id/BAA15979 EnsemblBacteria BAA15979 http://www.ensemblgenomes.org/id/BAA15979 EnsemblBacteria BAA15979 http://www.ensemblgenomes.org/id/BAA15979 EnsemblBacteria b2170 http://www.ensemblgenomes.org/id/b2170 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015542 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015542 GO_process GO:0007059 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007059 GO_process GO:0015758 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015758 GO_process GO:0015767 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015767 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0007059 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007059 GeneID 946673 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946673 HOGENOM HOG000281090 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000281090&db=HOGENOM6 InParanoid P33026 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33026 InterPro IPR004750 http://www.ebi.ac.uk/interpro/entry/IPR004750 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2157 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2157 KEGG_Gene eco:b2170 http://www.genome.jp/dbget-bin/www_bget?eco:b2170 KEGG_Orthology KO:K03291 http://www.genome.jp/dbget-bin/www_bget?KO:K03291 OMA FGFTVMY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FGFTVMY PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:SETB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SETB_ECOLI PSORT-B swissprot:SETB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SETB_ECOLI PSORT2 swissprot:SETB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SETB_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:SETB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SETB_ECOLI PhylomeDB P33026 http://phylomedb.org/?seqid=P33026 ProteinModelPortal P33026 http://www.proteinmodelportal.org/query/uniprot/P33026 PubMed 10209755 http://www.ncbi.nlm.nih.gov/pubmed/10209755 PubMed 10438463 http://www.ncbi.nlm.nih.gov/pubmed/10438463 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416675 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416675 RefSeq WP_000551980 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000551980 STRING 511145.b2170 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2170&targetmode=cogs STRING COG0477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0477&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.20 http://www.tcdb.org/search/result.php?tc=2.A.1.20 TIGRFAMs TIGR00899 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00899 UniProtKB SETB_ECOLI http://www.uniprot.org/uniprot/SETB_ECOLI UniProtKB-AC P33026 http://www.uniprot.org/uniprot/P33026 charge swissprot:SETB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SETB_ECOLI eggNOG ENOG4105S8Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105S8Q eggNOG ENOG410XTE9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XTE9 epestfind swissprot:SETB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SETB_ECOLI garnier swissprot:SETB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SETB_ECOLI helixturnhelix swissprot:SETB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SETB_ECOLI hmoment swissprot:SETB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SETB_ECOLI iep swissprot:SETB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SETB_ECOLI inforesidue swissprot:SETB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SETB_ECOLI octanol swissprot:SETB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SETB_ECOLI pepcoil swissprot:SETB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SETB_ECOLI pepdigest swissprot:SETB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SETB_ECOLI pepinfo swissprot:SETB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SETB_ECOLI pepnet swissprot:SETB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SETB_ECOLI pepstats swissprot:SETB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SETB_ECOLI pepwheel swissprot:SETB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SETB_ECOLI pepwindow swissprot:SETB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SETB_ECOLI sigcleave swissprot:SETB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SETB_ECOLI ## Database ID URL or Descriptions # AltName ACRR_ECOLI Potential acrAB operon repressor # BioGrid 4260988 9 # EcoGene EG12116 acrR # FUNCTION ACRR_ECOLI Potential regulator protein for the acrAB genes. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IDA:EcoCyc. # GO_function GO:0008144 drug binding; IDA:EcoCyc. # GO_function GO:0043565 sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0042493 response to drug; IDA:EcoCyc. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.60 -; 2. # Gene3D 1.10.357.10 -; 1. # INTERACTION ACRR_ECOLI P76215 astE; NbExp=3; IntAct=EBI-1117360, EBI-1121806; # IntAct P0ACS9 19 # InterPro IPR001647 HTH_TetR # InterPro IPR009057 Homeodomain-like # InterPro IPR011075 Tet_transcr_reg_TetR-rel_C # InterPro IPR013572 Tscrpt_reg_MAATS_C # InterPro IPR015893 Tet_transcr_reg_TetR-like_C # InterPro IPR023772 DNA-bd_HTH_TetR-type_CS # KEGG_Brite ko03000 Transcription factors # Organism ACRR_ECOLI Escherichia coli (strain K12) # PATRIC 32116081 VBIEscCol129921_0482 # PDB 2QOP X-ray; 2.55 A; A=1-215 # PDB 3BCG X-ray; 2.48 A; A/B=1-215 # PIR G64776 G64776 # PRINTS PR00455 HTHTETR # PROSITE PS01081 HTH_TETR_1 # PROSITE PS50977 HTH_TETR_2 # Pfam PF00440 TetR_N # Pfam PF08361 TetR_C_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ACRR_ECOLI HTH-type transcriptional regulator AcrR # RefSeq NP_414997 NC_000913.3 # RefSeq WP_000101737 NZ_LN832404.1 # SIMILARITY Contains 1 HTH tetR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00335}. # SUPFAM SSF46689 SSF46689 # SUPFAM SSF48498 SSF48498 # eggNOG COG1309 LUCA # eggNOG ENOG4107XI7 Bacteria BLAST swissprot:ACRR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ACRR_ECOLI BioCyc ECOL316407:JW0453-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0453-MONOMER BioCyc EcoCyc:EG12116-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12116-MONOMER COG COG1309 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1309 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U00734 http://www.ebi.ac.uk/ena/data/view/U00734 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EchoBASE EB2039 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2039 EcoGene EG12116 http://www.ecogene.org/geneInfo.php?eg_id=EG12116 EnsemblBacteria AAC73566 http://www.ensemblgenomes.org/id/AAC73566 EnsemblBacteria AAC73566 http://www.ensemblgenomes.org/id/AAC73566 EnsemblBacteria BAE76243 http://www.ensemblgenomes.org/id/BAE76243 EnsemblBacteria BAE76243 http://www.ensemblgenomes.org/id/BAE76243 EnsemblBacteria BAE76243 http://www.ensemblgenomes.org/id/BAE76243 EnsemblBacteria b0464 http://www.ensemblgenomes.org/id/b0464 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0008144 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008144 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0042493 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 Gene3D 1.10.357.10 http://www.cathdb.info/version/latest/superfamily/1.10.357.10 GeneID 945516 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945516 HOGENOM HOG000260115 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260115&db=HOGENOM6 InParanoid P0ACS9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACS9 IntAct P0ACS9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACS9* InterPro IPR001647 http://www.ebi.ac.uk/interpro/entry/IPR001647 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR011075 http://www.ebi.ac.uk/interpro/entry/IPR011075 InterPro IPR013572 http://www.ebi.ac.uk/interpro/entry/IPR013572 InterPro IPR015893 http://www.ebi.ac.uk/interpro/entry/IPR015893 InterPro IPR023772 http://www.ebi.ac.uk/interpro/entry/IPR023772 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW0453 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0453 KEGG_Gene eco:b0464 http://www.genome.jp/dbget-bin/www_bget?eco:b0464 KEGG_Orthology KO:K03577 http://www.genome.jp/dbget-bin/www_bget?KO:K03577 OMA MMEIIFH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MMEIIFH PDB 2QOP http://www.ebi.ac.uk/pdbe-srv/view/entry/2QOP PDB 3BCG http://www.ebi.ac.uk/pdbe-srv/view/entry/3BCG PDBsum 2QOP http://www.ebi.ac.uk/pdbsum/2QOP PDBsum 3BCG http://www.ebi.ac.uk/pdbsum/3BCG PRINTS PR00455 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00455 PROSITE PS01081 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01081 PROSITE PS50977 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50977 PSORT swissprot:ACRR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ACRR_ECOLI PSORT-B swissprot:ACRR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ACRR_ECOLI PSORT2 swissprot:ACRR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ACRR_ECOLI Pfam PF00440 http://pfam.xfam.org/family/PF00440 Pfam PF08361 http://pfam.xfam.org/family/PF08361 Phobius swissprot:ACRR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ACRR_ECOLI PhylomeDB P0ACS9 http://phylomedb.org/?seqid=P0ACS9 ProteinModelPortal P0ACS9 http://www.proteinmodelportal.org/query/uniprot/P0ACS9 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8407802 http://www.ncbi.nlm.nih.gov/pubmed/8407802 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414997 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414997 RefSeq WP_000101737 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000101737 SMR P0ACS9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACS9 STRING 511145.b0464 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0464&targetmode=cogs STRING COG1309 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1309&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF48498 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48498 UniProtKB ACRR_ECOLI http://www.uniprot.org/uniprot/ACRR_ECOLI UniProtKB-AC P0ACS9 http://www.uniprot.org/uniprot/P0ACS9 charge swissprot:ACRR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ACRR_ECOLI eggNOG COG1309 http://eggnogapi.embl.de/nog_data/html/tree/COG1309 eggNOG ENOG4107XI7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107XI7 epestfind swissprot:ACRR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ACRR_ECOLI garnier swissprot:ACRR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ACRR_ECOLI helixturnhelix swissprot:ACRR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ACRR_ECOLI hmoment swissprot:ACRR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ACRR_ECOLI iep swissprot:ACRR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ACRR_ECOLI inforesidue swissprot:ACRR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ACRR_ECOLI octanol swissprot:ACRR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ACRR_ECOLI pepcoil swissprot:ACRR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ACRR_ECOLI pepdigest swissprot:ACRR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ACRR_ECOLI pepinfo swissprot:ACRR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ACRR_ECOLI pepnet swissprot:ACRR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ACRR_ECOLI pepstats swissprot:ACRR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ACRR_ECOLI pepwheel swissprot:ACRR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ACRR_ECOLI pepwindow swissprot:ACRR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ACRR_ECOLI sigcleave swissprot:ACRR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ACRR_ECOLI ## Database ID URL or Descriptions # CDD cd06261 TM_PBP2 # EcoGene EG12040 yejE # FUNCTION YEJE_ECOLI Probably part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; ISS:EcoCyc. # GO_function GO:0043492 ATPase activity, coupled to movement of substances; ISS:EcoCyc. # GO_process GO:0042884 microcin transport; IMP:EcoCyc. # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016887 ATPase activity # GOslim_process GO:0006810 transport # Gene3D 1.10.3720.10 -; 1. # InterPro IPR000515 MetI-like # InterPro IPR025966 OppC_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00349 Microcin C transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism YEJE_ECOLI Escherichia coli (strain K12) # PATRIC 32119713 VBIEscCol129921_2267 # PIR B64987 B64987 # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Pfam PF12911 OppC_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEJE_ECOLI Inner membrane ABC transporter permease protein YejE # RefSeq NP_416684 NC_000913.3 # RefSeq WP_000088923 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION YEJE_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF161098 SSF161098 # TCDB 3.A.1.5.21 the atp-binding cassette (abc) superfamily # eggNOG COG4239 LUCA # eggNOG ENOG4108IYQ Bacteria BLAST swissprot:YEJE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEJE_ECOLI BioCyc ECOL316407:JW2167-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2167-MONOMER BioCyc EcoCyc:YEJE-MONOMER http://biocyc.org/getid?id=EcoCyc:YEJE-MONOMER COG COG4239 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4239 DIP DIP-11935N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11935N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00008 http://www.ebi.ac.uk/ena/data/view/U00008 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1974 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1974 EcoGene EG12040 http://www.ecogene.org/geneInfo.php?eg_id=EG12040 EnsemblBacteria AAC75240 http://www.ensemblgenomes.org/id/AAC75240 EnsemblBacteria AAC75240 http://www.ensemblgenomes.org/id/AAC75240 EnsemblBacteria BAA15987 http://www.ensemblgenomes.org/id/BAA15987 EnsemblBacteria BAA15987 http://www.ensemblgenomes.org/id/BAA15987 EnsemblBacteria BAA15987 http://www.ensemblgenomes.org/id/BAA15987 EnsemblBacteria b2179 http://www.ensemblgenomes.org/id/b2179 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0043492 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043492 GO_process GO:0042884 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042884 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 946683 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946683 HOGENOM HOG000171366 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000171366&db=HOGENOM6 InParanoid P33915 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33915 IntAct P33915 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33915* InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 InterPro IPR025966 http://www.ebi.ac.uk/interpro/entry/IPR025966 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2167 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2167 KEGG_Gene eco:b2179 http://www.genome.jp/dbget-bin/www_bget?eco:b2179 KEGG_Orthology KO:K13895 http://www.genome.jp/dbget-bin/www_bget?KO:K13895 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA PSPPTWM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PSPPTWM PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:YEJE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEJE_ECOLI PSORT-B swissprot:YEJE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEJE_ECOLI PSORT2 swissprot:YEJE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEJE_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Pfam PF12911 http://pfam.xfam.org/family/PF12911 Phobius swissprot:YEJE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEJE_ECOLI PhylomeDB P33915 http://phylomedb.org/?seqid=P33915 ProteinModelPortal P33915 http://www.proteinmodelportal.org/query/uniprot/P33915 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416684 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416684 RefSeq WP_000088923 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000088923 SMR P33915 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33915 STRING 511145.b2179 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2179&targetmode=cogs STRING COG4239 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4239&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.5.21 http://www.tcdb.org/search/result.php?tc=3.A.1.5.21 UniProtKB YEJE_ECOLI http://www.uniprot.org/uniprot/YEJE_ECOLI UniProtKB-AC P33915 http://www.uniprot.org/uniprot/P33915 charge swissprot:YEJE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEJE_ECOLI eggNOG COG4239 http://eggnogapi.embl.de/nog_data/html/tree/COG4239 eggNOG ENOG4108IYQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108IYQ epestfind swissprot:YEJE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEJE_ECOLI garnier swissprot:YEJE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEJE_ECOLI helixturnhelix swissprot:YEJE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEJE_ECOLI hmoment swissprot:YEJE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEJE_ECOLI iep swissprot:YEJE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEJE_ECOLI inforesidue swissprot:YEJE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEJE_ECOLI octanol swissprot:YEJE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEJE_ECOLI pepcoil swissprot:YEJE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEJE_ECOLI pepdigest swissprot:YEJE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEJE_ECOLI pepinfo swissprot:YEJE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEJE_ECOLI pepnet swissprot:YEJE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEJE_ECOLI pepstats swissprot:YEJE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEJE_ECOLI pepwheel swissprot:YEJE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEJE_ECOLI pepwindow swissprot:YEJE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEJE_ECOLI sigcleave swissprot:YEJE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEJE_ECOLI ## Database ID URL or Descriptions # AltName Short-chain acyl-CoA acetate CoA-transferase # BioGrid 4260290 15 # CATALYTIC ACTIVITY YDIF_ECOLI Acyl-CoA + acetate = a fatty acid anion + acetyl-CoA. # EcoGene EG12432 ydiF # FUNCTION YDIF_ECOLI CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons. May play a role in short-chain fatty acid metabolism in E.coli (By similarity). {ECO 0000250}. # GO_function GO:0008775 acetate CoA-transferase activity; ISS:UniProtKB. # GO_process GO:0046459 short-chain fatty acid metabolic process; ISS:UniProtKB. # GO_process GO:0046952 ketone body catabolic process; IEA:InterPro. # GO_process GO:0051289 protein homotetramerization; ISS:UniProtKB. # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # IntAct P37766 2 # InterPro IPR004165 CoA_trans_fam_I # InterPro IPR014388 3-oxoacid_CoA-transferase # MISCELLANEOUS Formation of the covalent enzyme-CoA thioester intermediate proceeds via an unstable anhydride species formed between the carboxylate group of the catalytic glutamate of the enzyme and the carbonyl carbon of the thioester linkage of the substrate. {ECO 0000250}. # Organism YDIF_ECOLI Escherichia coli (strain K12) # PANTHER PTHR13707 PTHR13707 # PATRIC 32118694 VBIEscCol129921_1765 # PIR F64927 F64927 # PIRSF PIRSF000858 SCOT-t # Pfam PF01144 CoA_trans # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDIF_ECOLI Acetate CoA-transferase YdiF # RefSeq NP_416209 NC_000913.3 # RefSeq WP_000805700 NZ_CP011343.2 # SIMILARITY Belongs to the 3-oxoacid CoA-transferase family. {ECO 0000305}. # SMART SM00882 CoA_trans # SUBUNIT Homotetramer; dimer of dimers. {ECO 0000250}. # eggNOG COG4670 LUCA # eggNOG ENOG4107R0K Bacteria BLAST swissprot:YDIF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDIF_ECOLI BioCyc ECOL316407:JW1684-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1684-MONOMER BioCyc EcoCyc:EG12432-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12432-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2380475 http://dx.doi.org/10.1042/bj2380475 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.8.3.8 http://www.genome.jp/dbget-bin/www_bget?EC:2.8.3.8 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X04306 http://www.ebi.ac.uk/ena/data/view/X04306 ENZYME 2.8.3.8 http://enzyme.expasy.org/EC/2.8.3.8 EchoBASE EB2328 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2328 EcoGene EG12432 http://www.ecogene.org/geneInfo.php?eg_id=EG12432 EnsemblBacteria AAC74764 http://www.ensemblgenomes.org/id/AAC74764 EnsemblBacteria AAC74764 http://www.ensemblgenomes.org/id/AAC74764 EnsemblBacteria BAA15447 http://www.ensemblgenomes.org/id/BAA15447 EnsemblBacteria BAA15447 http://www.ensemblgenomes.org/id/BAA15447 EnsemblBacteria BAA15447 http://www.ensemblgenomes.org/id/BAA15447 EnsemblBacteria b1694 http://www.ensemblgenomes.org/id/b1694 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008775 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008775 GO_process GO:0046459 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046459 GO_process GO:0046952 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046952 GO_process GO:0051289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051289 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 946211 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946211 HOGENOM HOG000058376 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000058376&db=HOGENOM6 InParanoid P37766 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37766 IntAct P37766 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37766* IntEnz 2.8.3.8 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.8.3.8 InterPro IPR004165 http://www.ebi.ac.uk/interpro/entry/IPR004165 InterPro IPR014388 http://www.ebi.ac.uk/interpro/entry/IPR014388 KEGG_Gene ecj:JW1684 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1684 KEGG_Gene eco:b1694 http://www.genome.jp/dbget-bin/www_bget?eco:b1694 OMA ASDLKVM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ASDLKVM PANTHER PTHR13707 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13707 PSORT swissprot:YDIF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDIF_ECOLI PSORT-B swissprot:YDIF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDIF_ECOLI PSORT2 swissprot:YDIF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDIF_ECOLI Pfam PF01144 http://pfam.xfam.org/family/PF01144 Phobius swissprot:YDIF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDIF_ECOLI PhylomeDB P37766 http://phylomedb.org/?seqid=P37766 ProteinModelPortal P37766 http://www.proteinmodelportal.org/query/uniprot/P37766 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3541912 http://www.ncbi.nlm.nih.gov/pubmed/3541912 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416209 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416209 RefSeq WP_000805700 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000805700 SMART SM00882 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00882 SMR P37766 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37766 STRING 511145.b1694 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1694&targetmode=cogs UniProtKB YDIF_ECOLI http://www.uniprot.org/uniprot/YDIF_ECOLI UniProtKB-AC P37766 http://www.uniprot.org/uniprot/P37766 charge swissprot:YDIF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDIF_ECOLI eggNOG COG4670 http://eggnogapi.embl.de/nog_data/html/tree/COG4670 eggNOG ENOG4107R0K http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107R0K epestfind swissprot:YDIF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDIF_ECOLI garnier swissprot:YDIF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDIF_ECOLI helixturnhelix swissprot:YDIF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDIF_ECOLI hmoment swissprot:YDIF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDIF_ECOLI iep swissprot:YDIF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDIF_ECOLI inforesidue swissprot:YDIF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDIF_ECOLI octanol swissprot:YDIF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDIF_ECOLI pepcoil swissprot:YDIF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDIF_ECOLI pepdigest swissprot:YDIF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDIF_ECOLI pepinfo swissprot:YDIF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDIF_ECOLI pepnet swissprot:YDIF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDIF_ECOLI pepstats swissprot:YDIF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDIF_ECOLI pepwheel swissprot:YDIF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDIF_ECOLI pepwindow swissprot:YDIF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDIF_ECOLI sigcleave swissprot:YDIF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDIF_ECOLI ## Database ID URL or Descriptions # BioGrid 4261444 20 # EcoGene EG13105 ygbK # IntAct Q46889 3 # InterPro IPR010737 DUF1537 # InterPro IPR031475 DUF1537_C # Organism YGBK_ECOLI Escherichia coli (strain K12) # PATRIC 32120876 VBIEscCol129921_2830 # PIR E65054 E65054 # Pfam PF07005 DUF1537 # Pfam PF17042 DUF1357_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGBK_ECOLI Uncharacterized protein YgbK # RefSeq NP_417217 NC_000913.3 # RefSeq WP_001393459 NZ_LN832404.1 # SIMILARITY To H.influenzae HI_1011. {ECO 0000305}. # eggNOG COG3395 LUCA # eggNOG ENOG4105G63 Bacteria BLAST swissprot:YGBK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGBK_ECOLI BioCyc ECOL316407:JW2707-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2707-MONOMER BioCyc EcoCyc:G7418-MONOMER http://biocyc.org/getid?id=EcoCyc:G7418-MONOMER DIP DIP-12112N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12112N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EchoBASE EB2908 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2908 EcoGene EG13105 http://www.ecogene.org/geneInfo.php?eg_id=EG13105 EnsemblBacteria AAC75779 http://www.ensemblgenomes.org/id/AAC75779 EnsemblBacteria AAC75779 http://www.ensemblgenomes.org/id/AAC75779 EnsemblBacteria BAE76814 http://www.ensemblgenomes.org/id/BAE76814 EnsemblBacteria BAE76814 http://www.ensemblgenomes.org/id/BAE76814 EnsemblBacteria BAE76814 http://www.ensemblgenomes.org/id/BAE76814 EnsemblBacteria b2737 http://www.ensemblgenomes.org/id/b2737 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947199 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947199 HOGENOM HOG000218170 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218170&db=HOGENOM6 InParanoid Q46889 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46889 IntAct Q46889 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46889* InterPro IPR010737 http://www.ebi.ac.uk/interpro/entry/IPR010737 InterPro IPR031475 http://www.ebi.ac.uk/interpro/entry/IPR031475 KEGG_Gene ecj:JW2707 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2707 KEGG_Gene eco:b2737 http://www.genome.jp/dbget-bin/www_bget?eco:b2737 OMA HPLTPMR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HPLTPMR PSORT swissprot:YGBK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGBK_ECOLI PSORT-B swissprot:YGBK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGBK_ECOLI PSORT2 swissprot:YGBK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGBK_ECOLI Pfam PF07005 http://pfam.xfam.org/family/PF07005 Pfam PF17042 http://pfam.xfam.org/family/PF17042 Phobius swissprot:YGBK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGBK_ECOLI PhylomeDB Q46889 http://phylomedb.org/?seqid=Q46889 ProteinModelPortal Q46889 http://www.proteinmodelportal.org/query/uniprot/Q46889 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417217 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417217 RefSeq WP_001393459 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001393459 SMR Q46889 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46889 STRING 511145.b2737 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2737&targetmode=cogs UniProtKB YGBK_ECOLI http://www.uniprot.org/uniprot/YGBK_ECOLI UniProtKB-AC Q46889 http://www.uniprot.org/uniprot/Q46889 charge swissprot:YGBK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGBK_ECOLI eggNOG COG3395 http://eggnogapi.embl.de/nog_data/html/tree/COG3395 eggNOG ENOG4105G63 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105G63 epestfind swissprot:YGBK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGBK_ECOLI garnier swissprot:YGBK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGBK_ECOLI helixturnhelix swissprot:YGBK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGBK_ECOLI hmoment swissprot:YGBK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGBK_ECOLI iep swissprot:YGBK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGBK_ECOLI inforesidue swissprot:YGBK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGBK_ECOLI octanol swissprot:YGBK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGBK_ECOLI pepcoil swissprot:YGBK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGBK_ECOLI pepdigest swissprot:YGBK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGBK_ECOLI pepinfo swissprot:YGBK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGBK_ECOLI pepnet swissprot:YGBK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGBK_ECOLI pepstats swissprot:YGBK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGBK_ECOLI pepwheel swissprot:YGBK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGBK_ECOLI pepwindow swissprot:YGBK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGBK_ECOLI sigcleave swissprot:YGBK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGBK_ECOLI ## Database ID URL or Descriptions # AltName Aspartate-beta-semialdehyde dehydrogenase {ECO:0000255|HAMAP-Rule MF_02121} # BIOPHYSICOCHEMICAL PROPERTIES DHAS_ECOLI Kinetic parameters KM=22 uM for L-4-aspartyl phosphate {ECO 0000269|PubMed 11368768}; KM=29 uM for NADPH {ECO 0000269|PubMed 11368768}; KM=110 uM for L-aspartate 4-semialdehyde {ECO 0000269|PubMed 11368768}; KM=144 uM for NADP(+) {ECO 0000269|PubMed 11368768}; KM=10.2 mM for phosphate {ECO 0000269|PubMed 11368768}; # BRENDA 1.2.1.11 2026 # CATALYTIC ACTIVITY DHAS_ECOLI L-aspartate 4-semialdehyde + phosphate + NADP(+) = L-4-aspartyl phosphate + NADPH. {ECO 0000269|PubMed 11368768, ECO 0000269|PubMed 6102909}. # DOMAIN DHAS_ECOLI Consists of two domains, an N-terminal nucleotide-binding domain and a C-terminal dimerization domain. {ECO 0000269|PubMed 10369777}. # ENZYME REGULATION Is inhibited by L- and D-cystine, and by other cystine derivatives, via the formation of a covalently bound cysteine at the active site Cys-135. {ECO:0000269|PubMed 14726201}. # EcoGene EG10088 asd # FUNCTION DHAS_ECOLI Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate. {ECO 0000269|PubMed 11368768, ECO 0000269|PubMed 6102909}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003942 N-acetyl-gamma-glutamyl-phosphate reductase activity; IEA:InterPro. # GO_function GO:0004073 aspartate-semialdehyde dehydrogenase activity; IDA:EcoCyc. # GO_function GO:0050661 NADP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0051287 NAD binding; IEA:InterPro. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0009088 threonine biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0009089 lysine biosynthetic process via diaminopimelate; IDA:EcoCyc. # GO_process GO:0009090 homoserine biosynthetic process; IDA:EcoCyc. # GO_process GO:0009097 isoleucine biosynthetic process; IEA:InterPro. # GO_process GO:0019877 diaminopimelate biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0071266 'de novo' L-methionine biosynthetic process; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.720 -; 1. # HAMAP MF_02121 ASADH # InterPro IPR000319 Asp-semialdehyde_DH_CS # InterPro IPR000534 Semialdehyde_DH_NAD-bd # InterPro IPR011534 Asp_ADH_gamma-type # InterPro IPR012080 Asp_semialdehyde_DH # InterPro IPR012280 Semialdhyde_DH_dimer_dom # InterPro IPR016040 NAD(P)-bd_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00260 Glycine, serine and threonine metabolism # KEGG_Pathway ko00270 Cysteine and methionine metabolism # KEGG_Pathway ko00300 Lysine biosynthesis # Organism DHAS_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4. {ECO 0000255|HAMAP-Rule:MF_02121}. # PATHWAY Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3. {ECO 0000255|HAMAP-Rule:MF_02121}. # PATHWAY Amino-acid biosynthesis; L-threonine biosynthesis; L- threonine from L-aspartate: step 2/5. {ECO 0000255|HAMAP- Rule:MF_02121}. # PATRIC 32122306 VBIEscCol129921_3530 # PDB 1BRM X-ray; 2.50 A; A/B/C=1-367 # PDB 1GL3 X-ray; 2.60 A; A/B=1-367 # PDB 1T4B X-ray; 1.60 A; A/B=1-367 # PDB 1T4D X-ray; 1.95 A; A/B/C=1-367 # PIR A00364 DEECDA # PIRSF PIRSF000148 ASA_dh # PROSITE PS01103 ASD # Pfam PF01118 Semialdhyde_dh # Pfam PF02774 Semialdhyde_dhC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Aspartate-semialdehyde dehydrogenase {ECO:0000255|HAMAP-Rule MF_02121} # RefSeq NP_417891 NC_000913.3 # RefSeq WP_000799956 NZ_LN832404.1 # SIMILARITY Belongs to the aspartate-semialdehyde dehydrogenase family. {ECO:0000255|HAMAP-Rule MF_02121}. # SMART SM00859 Semialdhyde_dh # SUBUNIT DHAS_ECOLI Homodimer. {ECO 0000269|PubMed 11724560, ECO 0000269|PubMed 6102909}. # SUPFAM SSF51735 SSF51735 # TIGRFAMs TIGR01745 asd_gamma # UniPathway UPA00034 UER00016 # UniPathway UPA00050 UER00463 # UniPathway UPA00051 UER00464 # eggNOG COG0136 LUCA # eggNOG ENOG4105CM3 Bacteria BLAST swissprot:DHAS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DHAS_ECOLI BioCyc ECOL316407:JW3396-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3396-MONOMER BioCyc EcoCyc:ASP-SEMIALDEHYDE-DEHYDROGENASE-MONOMER http://biocyc.org/getid?id=EcoCyc:ASP-SEMIALDEHYDE-DEHYDROGENASE-MONOMER BioCyc MetaCyc:ASP-SEMIALDEHYDE-DEHYDROGENASE-MONOMER http://biocyc.org/getid?id=MetaCyc:ASP-SEMIALDEHYDE-DEHYDROGENASE-MONOMER COG COG0136 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0136 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1999.2828 http://dx.doi.org/10.1006/jmbi.1999.2828 DOI 10.1016/0167-4838(92)90360-P http://dx.doi.org/10.1016/0167-4838(92)90360-P DOI 10.1016/j.bbapap.2003.09.002 http://dx.doi.org/10.1016/j.bbapap.2003.09.002 DOI 10.1016/j.jmb.2004.05.073 http://dx.doi.org/10.1016/j.jmb.2004.05.073 DOI 10.1021/bi015713o http://dx.doi.org/10.1021/bi015713o DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/0264-6021:3560415 http://dx.doi.org/10.1042/0264-6021:3560415 DOI 10.1111/j.1432-1033.1980.tb04398.x http://dx.doi.org/10.1111/j.1432-1033.1980.tb04398.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.2.1.11 {ECO:0000269|PubMed:11368768, ECO:0000269|PubMed:6102909} http://www.genome.jp/dbget-bin/www_bget?EC:1.2.1.11 {ECO:0000269|PubMed:11368768, ECO:0000269|PubMed:6102909} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL V00262 http://www.ebi.ac.uk/ena/data/view/V00262 ENZYME 1.2.1.11 {ECO:0000269|PubMed:11368768, ECO:0000269|PubMed:6102909} http://enzyme.expasy.org/EC/1.2.1.11 {ECO:0000269|PubMed:11368768, ECO:0000269|PubMed:6102909} EchoBASE EB0086 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0086 EcoGene EG10088 http://www.ecogene.org/geneInfo.php?eg_id=EG10088 EnsemblBacteria AAC76458 http://www.ensemblgenomes.org/id/AAC76458 EnsemblBacteria AAC76458 http://www.ensemblgenomes.org/id/AAC76458 EnsemblBacteria BAE77859 http://www.ensemblgenomes.org/id/BAE77859 EnsemblBacteria BAE77859 http://www.ensemblgenomes.org/id/BAE77859 EnsemblBacteria BAE77859 http://www.ensemblgenomes.org/id/BAE77859 EnsemblBacteria b3433 http://www.ensemblgenomes.org/id/b3433 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003942 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003942 GO_function GO:0004073 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004073 GO_function GO:0050661 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050661 GO_function GO:0051287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051287 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0009088 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009088 GO_process GO:0009089 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009089 GO_process GO:0009090 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009090 GO_process GO:0009097 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009097 GO_process GO:0019877 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019877 GO_process GO:0071266 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071266 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 947939 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947939 HAMAP MF_02121 http://hamap.expasy.org/unirule/MF_02121 HOGENOM HOG000161376 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000161376&db=HOGENOM6 InParanoid P0A9Q9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9Q9 IntAct P0A9Q9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9Q9* IntEnz 1.2.1.11 {ECO:0000269|PubMed:11368768, ECO:0000269|PubMed:6102909} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.2.1.11 {ECO:0000269|PubMed:11368768, ECO:0000269|PubMed:6102909} InterPro IPR000319 http://www.ebi.ac.uk/interpro/entry/IPR000319 InterPro IPR000534 http://www.ebi.ac.uk/interpro/entry/IPR000534 InterPro IPR011534 http://www.ebi.ac.uk/interpro/entry/IPR011534 InterPro IPR012080 http://www.ebi.ac.uk/interpro/entry/IPR012080 InterPro IPR012280 http://www.ebi.ac.uk/interpro/entry/IPR012280 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3396 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3396 KEGG_Gene eco:b3433 http://www.genome.jp/dbget-bin/www_bget?eco:b3433 KEGG_Orthology KO:K00133 http://www.genome.jp/dbget-bin/www_bget?KO:K00133 KEGG_Pathway ko00260 http://www.genome.jp/kegg-bin/show_pathway?ko00260 KEGG_Pathway ko00270 http://www.genome.jp/kegg-bin/show_pathway?ko00270 KEGG_Pathway ko00300 http://www.genome.jp/kegg-bin/show_pathway?ko00300 KEGG_Reaction rn:R02291 http://www.genome.jp/dbget-bin/www_bget?rn:R02291 OMA SCQGGDY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SCQGGDY PDB 1BRM http://www.ebi.ac.uk/pdbe-srv/view/entry/1BRM PDB 1GL3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1GL3 PDB 1T4B http://www.ebi.ac.uk/pdbe-srv/view/entry/1T4B PDB 1T4D http://www.ebi.ac.uk/pdbe-srv/view/entry/1T4D PDBsum 1BRM http://www.ebi.ac.uk/pdbsum/1BRM PDBsum 1GL3 http://www.ebi.ac.uk/pdbsum/1GL3 PDBsum 1T4B http://www.ebi.ac.uk/pdbsum/1T4B PDBsum 1T4D http://www.ebi.ac.uk/pdbsum/1T4D PROSITE PS01103 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01103 PSORT swissprot:DHAS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DHAS_ECOLI PSORT-B swissprot:DHAS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DHAS_ECOLI PSORT2 swissprot:DHAS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DHAS_ECOLI Pfam PF01118 http://pfam.xfam.org/family/PF01118 Pfam PF02774 http://pfam.xfam.org/family/PF02774 Phobius swissprot:DHAS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DHAS_ECOLI PhylomeDB P0A9Q9 http://phylomedb.org/?seqid=P0A9Q9 ProteinModelPortal P0A9Q9 http://www.proteinmodelportal.org/query/uniprot/P0A9Q9 PubMed 10369777 http://www.ncbi.nlm.nih.gov/pubmed/10369777 PubMed 11368768 http://www.ncbi.nlm.nih.gov/pubmed/11368768 PubMed 11724560 http://www.ncbi.nlm.nih.gov/pubmed/11724560 PubMed 1350921 http://www.ncbi.nlm.nih.gov/pubmed/1350921 PubMed 14726201 http://www.ncbi.nlm.nih.gov/pubmed/14726201 PubMed 15288787 http://www.ncbi.nlm.nih.gov/pubmed/15288787 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6102909 http://www.ncbi.nlm.nih.gov/pubmed/6102909 PubMed 6143662 http://www.ncbi.nlm.nih.gov/pubmed/6143662 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_417891 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417891 RefSeq WP_000799956 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000799956 SMART SM00859 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00859 SMR P0A9Q9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9Q9 STRING 511145.b3433 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3433&targetmode=cogs STRING COG0136 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0136&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 SWISS-2DPAGE P0A9Q9 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A9Q9 TIGRFAMs TIGR01745 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01745 UniProtKB DHAS_ECOLI http://www.uniprot.org/uniprot/DHAS_ECOLI UniProtKB-AC P0A9Q9 http://www.uniprot.org/uniprot/P0A9Q9 charge swissprot:DHAS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DHAS_ECOLI eggNOG COG0136 http://eggnogapi.embl.de/nog_data/html/tree/COG0136 eggNOG ENOG4105CM3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CM3 epestfind swissprot:DHAS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DHAS_ECOLI garnier swissprot:DHAS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DHAS_ECOLI helixturnhelix swissprot:DHAS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DHAS_ECOLI hmoment swissprot:DHAS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DHAS_ECOLI iep swissprot:DHAS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DHAS_ECOLI inforesidue swissprot:DHAS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DHAS_ECOLI octanol swissprot:DHAS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DHAS_ECOLI pepcoil swissprot:DHAS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DHAS_ECOLI pepdigest swissprot:DHAS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DHAS_ECOLI pepinfo swissprot:DHAS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DHAS_ECOLI pepnet swissprot:DHAS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DHAS_ECOLI pepstats swissprot:DHAS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DHAS_ECOLI pepwheel swissprot:DHAS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DHAS_ECOLI pepwindow swissprot:DHAS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DHAS_ECOLI sigcleave swissprot:DHAS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DHAS_ECOLI ## Database ID URL or Descriptions # AltName URAA_ECOLI Uracil transporter # BioGrid 4261437 8 # EcoGene EG12129 uraA # FUNCTION URAA_ECOLI Transport of uracil in the cell. {ECO 0000269|PubMed 21423164, ECO 0000269|PubMed 7721693}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IDA:UniProtKB. # GO_function GO:0015210 uracil transmembrane transporter activity; IDA:EcoCyc. # GO_process GO:0015857 uracil transport; IDA:UniProtKB. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR006042 Xan_ur_permease # InterPro IPR006043 Xant/urac/vitC # KEGG_Brite ko02000 Transporters # Organism URAA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11119 PTHR11119 # PATRIC 32120381 VBIEscCol129921_2593 # PDB 3QE7 X-ray; 2.78 A; A=1-429 # PIR A56265 A56265 # PROSITE PS01116 XANTH_URACIL_PERMASE # Pfam PF00860 Xan_ur_permease # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName URAA_ECOLI Uracil permease # RefSeq NP_416992 NC_000913.3 # RefSeq WP_000198328 NZ_LN832404.1 # SIMILARITY Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION URAA_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # TCDB 2.A.40.1:the nucleobase/ascorbate transporter (nat) or nucleobase cation symporter-2 (ncs2) family # TIGRFAMs TIGR00801 ncs2 # eggNOG COG2233 LUCA # eggNOG ENOG4105C2W Bacteria BLAST swissprot:URAA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:URAA_ECOLI BioCyc ECOL316407:JW2482-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2482-MONOMER BioCyc EcoCyc:URAA-MONOMER http://biocyc.org/getid?id=EcoCyc:URAA-MONOMER BioCyc MetaCyc:URAA-MONOMER http://biocyc.org/getid?id=MetaCyc:URAA-MONOMER COG COG2233 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2233 DIP DIP-11094N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11094N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature09885 http://dx.doi.org/10.1038/nature09885 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X73586 http://www.ebi.ac.uk/ena/data/view/X73586 EchoBASE EB2050 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2050 EcoGene EG12129 http://www.ecogene.org/geneInfo.php?eg_id=EG12129 EnsemblBacteria AAC75550 http://www.ensemblgenomes.org/id/AAC75550 EnsemblBacteria AAC75550 http://www.ensemblgenomes.org/id/AAC75550 EnsemblBacteria BAA16385 http://www.ensemblgenomes.org/id/BAA16385 EnsemblBacteria BAA16385 http://www.ensemblgenomes.org/id/BAA16385 EnsemblBacteria BAA16385 http://www.ensemblgenomes.org/id/BAA16385 EnsemblBacteria b2497 http://www.ensemblgenomes.org/id/b2497 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015210 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015210 GO_process GO:0015857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015857 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 946978 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946978 HOGENOM HOG000038200 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000038200&db=HOGENOM6 InParanoid P0AGM7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGM7 IntAct P0AGM7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AGM7* InterPro IPR006042 http://www.ebi.ac.uk/interpro/entry/IPR006042 InterPro IPR006043 http://www.ebi.ac.uk/interpro/entry/IPR006043 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2482 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2482 KEGG_Gene eco:b2497 http://www.genome.jp/dbget-bin/www_bget?eco:b2497 KEGG_Orthology KO:K02824 http://www.genome.jp/dbget-bin/www_bget?KO:K02824 MINT MINT-1238837 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1238837 OMA NIEFEGM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NIEFEGM PANTHER PTHR11119 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11119 PDB 3QE7 http://www.ebi.ac.uk/pdbe-srv/view/entry/3QE7 PDBsum 3QE7 http://www.ebi.ac.uk/pdbsum/3QE7 PROSITE PS01116 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01116 PSORT swissprot:URAA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:URAA_ECOLI PSORT-B swissprot:URAA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:URAA_ECOLI PSORT2 swissprot:URAA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:URAA_ECOLI Pfam PF00860 http://pfam.xfam.org/family/PF00860 Phobius swissprot:URAA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:URAA_ECOLI PhylomeDB P0AGM7 http://phylomedb.org/?seqid=P0AGM7 ProteinModelPortal P0AGM7 http://www.proteinmodelportal.org/query/uniprot/P0AGM7 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21423164 http://www.ncbi.nlm.nih.gov/pubmed/21423164 PubMed 7721693 http://www.ncbi.nlm.nih.gov/pubmed/7721693 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416992 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416992 RefSeq WP_000198328 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000198328 SMR P0AGM7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AGM7 STRING 511145.b2497 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2497&targetmode=cogs STRING COG2233 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2233&targetmode=cogs TCDB 2.A.40.1 http://www.tcdb.org/search/result.php?tc=2.A.40.1 TIGRFAMs TIGR00801 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00801 UniProtKB URAA_ECOLI http://www.uniprot.org/uniprot/URAA_ECOLI UniProtKB-AC P0AGM7 http://www.uniprot.org/uniprot/P0AGM7 charge swissprot:URAA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:URAA_ECOLI eggNOG COG2233 http://eggnogapi.embl.de/nog_data/html/tree/COG2233 eggNOG ENOG4105C2W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C2W epestfind swissprot:URAA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:URAA_ECOLI garnier swissprot:URAA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:URAA_ECOLI helixturnhelix swissprot:URAA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:URAA_ECOLI hmoment swissprot:URAA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:URAA_ECOLI iep swissprot:URAA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:URAA_ECOLI inforesidue swissprot:URAA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:URAA_ECOLI octanol swissprot:URAA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:URAA_ECOLI pepcoil swissprot:URAA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:URAA_ECOLI pepdigest swissprot:URAA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:URAA_ECOLI pepinfo swissprot:URAA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:URAA_ECOLI pepnet swissprot:URAA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:URAA_ECOLI pepstats swissprot:URAA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:URAA_ECOLI pepwheel swissprot:URAA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:URAA_ECOLI pepwindow swissprot:URAA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:URAA_ECOLI sigcleave swissprot:URAA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:URAA_ECOLI ## Database ID URL or Descriptions # AltName YCEH_ECOLI G20.3 # BioGrid 4260078 9 # EcoGene EG11537 yceH # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # Gene3D 1.10.10.10 -; 2. # HAMAP MF_01584 UPF0502 # IntAct P29217 3 # InterPro IPR007432 DUF480 # InterPro IPR011991 WHTH_DNA-bd_dom # Organism YCEH_ECOLI Escherichia coli (strain K12) # PATRIC 32117373 VBIEscCol129921_1109 # PIR H64849 H64849 # Pfam PF04337 DUF480 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UPF0502 protein YceH {ECO:0000255|HAMAP-Rule MF_01584} # RefSeq NP_415585 NC_000913.3 # RefSeq WP_000877107 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA24550.1; Type=Frameshift; Positions=110, 211; Evidence={ECO:0000305}; Sequence=X06118; Type=Frameshift; Positions=110, 118; Evidence={ECO 0000305}; # SIMILARITY Belongs to the UPF0502 family. {ECO:0000255|HAMAP- Rule MF_01584}. # SUPFAM SSF46785 SSF46785; 2 # eggNOG COG3132 LUCA # eggNOG ENOG4108YXG Bacteria BLAST swissprot:YCEH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCEH_ECOLI BioCyc ECOL316407:JW1054-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1054-MONOMER BioCyc EcoCyc:EG11537-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11537-MONOMER COG COG3132 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3132 DIP DIP-11527N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11527N DOI 10.1007/BF00331153 http://dx.doi.org/10.1007/BF00331153 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M99278 http://www.ebi.ac.uk/ena/data/view/M99278 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X06118 http://www.ebi.ac.uk/ena/data/view/X06118 EchoBASE EB1499 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1499 EcoGene EG11537 http://www.ecogene.org/geneInfo.php?eg_id=EG11537 EnsemblBacteria AAC74151 http://www.ensemblgenomes.org/id/AAC74151 EnsemblBacteria AAC74151 http://www.ensemblgenomes.org/id/AAC74151 EnsemblBacteria BAA35875 http://www.ensemblgenomes.org/id/BAA35875 EnsemblBacteria BAA35875 http://www.ensemblgenomes.org/id/BAA35875 EnsemblBacteria BAA35875 http://www.ensemblgenomes.org/id/BAA35875 EnsemblBacteria b1067 http://www.ensemblgenomes.org/id/b1067 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 945633 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945633 HAMAP MF_01584 http://hamap.expasy.org/unirule/MF_01584 HOGENOM HOG000217964 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000217964&db=HOGENOM6 InParanoid P29217 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P29217 IntAct P29217 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P29217* InterPro IPR007432 http://www.ebi.ac.uk/interpro/entry/IPR007432 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW1054 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1054 KEGG_Gene eco:b1067 http://www.genome.jp/dbget-bin/www_bget?eco:b1067 KEGG_Orthology KO:K09915 http://www.genome.jp/dbget-bin/www_bget?KO:K09915 MINT MINT-1235937 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1235937 OMA TSREPVM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TSREPVM PSORT swissprot:YCEH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCEH_ECOLI PSORT-B swissprot:YCEH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCEH_ECOLI PSORT2 swissprot:YCEH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCEH_ECOLI Pfam PF04337 http://pfam.xfam.org/family/PF04337 Phobius swissprot:YCEH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCEH_ECOLI PhylomeDB P29217 http://phylomedb.org/?seqid=P29217 ProteinModelPortal P29217 http://www.proteinmodelportal.org/query/uniprot/P29217 PubMed 1356970 http://www.ncbi.nlm.nih.gov/pubmed/1356970 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 2828880 http://www.ncbi.nlm.nih.gov/pubmed/2828880 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415585 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415585 RefSeq WP_000877107 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000877107 SMR P29217 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P29217 STRING 511145.b1067 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1067&targetmode=cogs STRING COG3132 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3132&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB YCEH_ECOLI http://www.uniprot.org/uniprot/YCEH_ECOLI UniProtKB-AC P29217 http://www.uniprot.org/uniprot/P29217 charge swissprot:YCEH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCEH_ECOLI eggNOG COG3132 http://eggnogapi.embl.de/nog_data/html/tree/COG3132 eggNOG ENOG4108YXG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108YXG epestfind swissprot:YCEH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCEH_ECOLI garnier swissprot:YCEH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCEH_ECOLI helixturnhelix swissprot:YCEH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCEH_ECOLI hmoment swissprot:YCEH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCEH_ECOLI iep swissprot:YCEH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCEH_ECOLI inforesidue swissprot:YCEH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCEH_ECOLI octanol swissprot:YCEH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCEH_ECOLI pepcoil swissprot:YCEH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCEH_ECOLI pepdigest swissprot:YCEH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCEH_ECOLI pepinfo swissprot:YCEH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCEH_ECOLI pepnet swissprot:YCEH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCEH_ECOLI pepstats swissprot:YCEH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCEH_ECOLI pepwheel swissprot:YCEH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCEH_ECOLI pepwindow swissprot:YCEH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCEH_ECOLI sigcleave swissprot:YCEH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCEH_ECOLI ## Database ID URL or Descriptions # AltName Restriction alleviation and modification enhancement protein {ECO:0000303|PubMed 7476171} # AltName Toxin RalR {ECO:0000303|PubMed 24748661} # BioGrid 4261586 121 # COFACTOR RALR_ECOLI Name=Ca(2+); Xref=ChEBI CHEBI 29108; Evidence={ECO 0000269|PubMed 24748661}; # COFACTOR RALR_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 24748661}; # DISRUPTION PHENOTYPE The single ralR and double ralR-ralA mutant have increased sensitivity to the antibiotic fosfomycin. {ECO:0000269|PubMed 24748661}. # ENZYME REGULATION Inhibited by EDTA. {ECO:0000269|PubMed 24748661}. # EcoGene EG11900 ralR # FUNCTION RALR_ECOLI Toxic component of a type I toxin-antitoxin (TA) module. Upon overexpression inhibits growth and reduces colony-forming units in both the presence and absence of the Rac prophage, cells become filamentous. Has deoxyribonuclease activity (probably endonucleolytic), does not digest RNA. Its toxic effects are neutralized by sRNA antitoxin RalA, which is encoded in trans on the opposite DNA strand (PubMed 24748661). Has RAL-like activity (PubMed 7476171). {ECO 0000269|PubMed 24748661, ECO 0000269|PubMed 7476171}. # GO_function GO:1990238 double-stranded DNA endodeoxyribonuclease activity; IDA:EcoCyc. # GO_process GO:0009307 DNA restriction-modification system; IEA:UniProtKB-KW. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GOslim_function GO:0004518 nuclease activity # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # INDUCTION The sRNA antitoxin RalA probably works by inhibiting translation of the RalR mRNA. The ability of RalA to block the toxicity of RalR relies on a 16-nt sequence which is complementary to a section of the RalR coding region; in the presence of RalA sRNA decreased amounts of RalR protein accumulate with no significant changes in the level of RalR RNA. {ECO:0000269|PubMed 24748661}. # InterPro IPR019908 Restrct_alleviation_prot_Lar # MISCELLANEOUS This protein is encoded on the Rac prophage. {ECO:0000303|PubMed 8244937}. # Organism RALR_ECOLI Escherichia coli (strain K12) # PIR G64884 G64884 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Endodeoxyribonuclease RalR {ECO:0000303|PubMed 24748661} # RefSeq NP_415864 NC_000913.3 # RefSeq WP_001317028 NZ_CP014272.1 # SEQUENCE CAUTION Sequence=AAA16180.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # TIGRFAMs TIGR03655 anti_R_Lar # eggNOG ENOG4106YAH Bacteria # eggNOG ENOG410YU07 LUCA BLAST swissprot:RALR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RALR_ECOLI BioCyc ECOL316407:JW5208-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5208-MONOMER BioCyc EcoCyc:EG11900-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11900-MONOMER BioCyc MetaCyc:EG11900-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11900-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/gku279 http://dx.doi.org/10.1093/nar/gku279 DOI 10.1111/j.1365-2958.1995.tb02438.x http://dx.doi.org/10.1111/j.1365-2958.1995.tb02438.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L23927 http://www.ebi.ac.uk/ena/data/view/L23927 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.-.- http://enzyme.expasy.org/EC/3.1.-.- EchoBASE EB1845 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1845 EcoGene EG11900 http://www.ecogene.org/geneInfo.php?eg_id=EG11900 EnsemblBacteria AAC74430 http://www.ensemblgenomes.org/id/AAC74430 EnsemblBacteria AAC74430 http://www.ensemblgenomes.org/id/AAC74430 EnsemblBacteria BAA14948 http://www.ensemblgenomes.org/id/BAA14948 EnsemblBacteria BAA14948 http://www.ensemblgenomes.org/id/BAA14948 EnsemblBacteria BAA14948 http://www.ensemblgenomes.org/id/BAA14948 EnsemblBacteria b1348 http://www.ensemblgenomes.org/id/b1348 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:1990238 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990238 GO_process GO:0009307 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009307 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 945914 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945914 HOGENOM HOG000054869 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000054869&db=HOGENOM6 IntEnz 3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1 InterPro IPR019908 http://www.ebi.ac.uk/interpro/entry/IPR019908 KEGG_Gene ecj:JW5208 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5208 KEGG_Gene eco:b1348 http://www.genome.jp/dbget-bin/www_bget?eco:b1348 OMA KIMRYDN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KIMRYDN PSORT swissprot:RALR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RALR_ECOLI PSORT-B swissprot:RALR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RALR_ECOLI PSORT2 swissprot:RALR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RALR_ECOLI Phobius swissprot:RALR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RALR_ECOLI ProteinModelPortal P33229 http://www.proteinmodelportal.org/query/uniprot/P33229 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 24748661 http://www.ncbi.nlm.nih.gov/pubmed/24748661 PubMed 7476171 http://www.ncbi.nlm.nih.gov/pubmed/7476171 PubMed 8244937 http://www.ncbi.nlm.nih.gov/pubmed/8244937 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415864 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415864 RefSeq WP_001317028 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001317028 STRING 511145.b1348 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1348&targetmode=cogs TIGRFAMs TIGR03655 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03655 UniProtKB RALR_ECOLI http://www.uniprot.org/uniprot/RALR_ECOLI UniProtKB-AC P33229 http://www.uniprot.org/uniprot/P33229 charge swissprot:RALR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RALR_ECOLI eggNOG ENOG4106YAH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106YAH eggNOG ENOG410YU07 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YU07 epestfind swissprot:RALR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RALR_ECOLI garnier swissprot:RALR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RALR_ECOLI helixturnhelix swissprot:RALR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RALR_ECOLI hmoment swissprot:RALR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RALR_ECOLI iep swissprot:RALR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RALR_ECOLI inforesidue swissprot:RALR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RALR_ECOLI octanol swissprot:RALR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RALR_ECOLI pepcoil swissprot:RALR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RALR_ECOLI pepdigest swissprot:RALR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RALR_ECOLI pepinfo swissprot:RALR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RALR_ECOLI pepnet swissprot:RALR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RALR_ECOLI pepstats swissprot:RALR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RALR_ECOLI pepwheel swissprot:RALR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RALR_ECOLI pepwindow swissprot:RALR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RALR_ECOLI sigcleave swissprot:RALR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RALR_ECOLI ## Database ID URL or Descriptions # AltName RHAR_ECOLI L-rhamnose operon transcriptional activator RhaR # BioGrid 4263058 8 # EcoGene EG10842 rhaR # FUNCTION RHAR_ECOLI Activates expression of the rhaSR operon in response to L-rhamnose. {ECO 0000269|PubMed 8230210, ECO 0000269|PubMed 8757746}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0000987 core promoter proximal region sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0043565 sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IBA:GO_Central. # GO_process GO:0019299 rhamnose metabolic process; IEA:UniProtKB-HAMAP. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.10.60 -; 2. # Gene3D 2.60.120.280 -; 1. # HAMAP MF_01533 HTH_type_RhaR # INDUCTION Autoregulated. Binding of the cAMP receptor protein (CRP) is required for full expression. {ECO:0000269|PubMed 8230210}. # IntAct P09378 9 # InterPro IPR003313 AraC-bd # InterPro IPR009057 Homeodomain-like # InterPro IPR011051 RmlC_Cupin # InterPro IPR018060 HTH_AraC # InterPro IPR018062 HTH_AraC-typ_CS # InterPro IPR020449 Tscrpt_reg_HTH_AraC-type # InterPro IPR023699 Tscrpt_act_RhaR # KEGG_Brite ko03000 Transcription factors # MISCELLANEOUS RHAR_ECOLI Its activity is regulated by L-rhamnose. When this sugar becomes available to the cell, basal-level RhaR binds L- rhamnose and becomes activated. # Organism RHAR_ECOLI Escherichia coli (strain K12) # PATRIC 32123323 VBIEscCol129921_4022 # PIR S40850 S40850 # PRINTS PR00032 HTHARAC # PROSITE PS00041 HTH_ARAC_FAMILY_1 # PROSITE PS01124 HTH_ARAC_FAMILY_2 # Pfam PF02311 AraC_binding # Pfam PF12833 HTH_18 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RHAR_ECOLI HTH-type transcriptional activator RhaR # RefSeq NP_418342 NC_000913.3 # RefSeq WP_001336056 NZ_LN832404.1 # SEQUENCE CAUTION RHAR_ECOLI Sequence=AAA24530.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO 0000305}; Sequence=AAB03039.1; Type=Erroneous initiation; Evidence={ECO 0000305}; Sequence=BAE77403.1; Type=Erroneous initiation; Evidence={ECO 0000305}; Sequence=CAA29453.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Contains 2 HTH araC/xylS-type DNA-binding domains. {ECO 0000305}. # SMART SM00342 HTH_ARAC # SUBCELLULAR LOCATION RHAR_ECOLI Cytoplasm. # SUBUNIT Binds DNA as a dimer. {ECO 0000305}. # SUPFAM SSF46689 SSF46689; 2 # SUPFAM SSF51182 SSF51182 # eggNOG ENOG4108BRW Bacteria # eggNOG ENOG410XYX0 LUCA BLAST swissprot:RHAR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RHAR_ECOLI BioCyc ECOL316407:JW3877-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3877-MONOMER BioCyc EcoCyc:PD00222 http://biocyc.org/getid?id=EcoCyc:PD00222 COG COG2207 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2207 DIP DIP-10693N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10693N DOI 10.1006/jmbi.1993.1565 http://dx.doi.org/10.1006/jmbi.1993.1565 DOI 10.1016/0022-2836(87)90405-0 http://dx.doi.org/10.1016/0022-2836(87)90405-0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1099/00221287-138-6-1109 http://dx.doi.org/10.1099/00221287-138-6-1109 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.23.6774-6782.2000 http://dx.doi.org/10.1128/JB.182.23.6774-6782.2000 DOI 10.1128/JB.186.18.6277-6285.2004 http://dx.doi.org/10.1128/JB.186.18.6277-6285.2004 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL M85158 http://www.ebi.ac.uk/ena/data/view/M85158 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X06058 http://www.ebi.ac.uk/ena/data/view/X06058 EMBL X60699 http://www.ebi.ac.uk/ena/data/view/X60699 EchoBASE EB0835 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0835 EcoGene EG10842 http://www.ecogene.org/geneInfo.php?eg_id=EG10842 EnsemblBacteria AAC76888 http://www.ensemblgenomes.org/id/AAC76888 EnsemblBacteria AAC76888 http://www.ensemblgenomes.org/id/AAC76888 EnsemblBacteria BAE77403 http://www.ensemblgenomes.org/id/BAE77403 EnsemblBacteria BAE77403 http://www.ensemblgenomes.org/id/BAE77403 EnsemblBacteria BAE77403 http://www.ensemblgenomes.org/id/BAE77403 EnsemblBacteria b3906 http://www.ensemblgenomes.org/id/b3906 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000987 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000987 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0019299 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019299 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 Gene3D 2.60.120.280 http://www.cathdb.info/version/latest/superfamily/2.60.120.280 GeneID 948396 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948396 HAMAP MF_01533 http://hamap.expasy.org/unirule/MF_01533 HOGENOM HOG000290513 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000290513&db=HOGENOM6 InParanoid P09378 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P09378 IntAct P09378 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P09378* InterPro IPR003313 http://www.ebi.ac.uk/interpro/entry/IPR003313 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR011051 http://www.ebi.ac.uk/interpro/entry/IPR011051 InterPro IPR018060 http://www.ebi.ac.uk/interpro/entry/IPR018060 InterPro IPR018062 http://www.ebi.ac.uk/interpro/entry/IPR018062 InterPro IPR020449 http://www.ebi.ac.uk/interpro/entry/IPR020449 InterPro IPR023699 http://www.ebi.ac.uk/interpro/entry/IPR023699 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW3877 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3877 KEGG_Gene eco:b3906 http://www.genome.jp/dbget-bin/www_bget?eco:b3906 KEGG_Orthology KO:K02854 http://www.genome.jp/dbget-bin/www_bget?KO:K02854 OMA FALDEFC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FALDEFC PRINTS PR00032 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00032 PROSITE PS00041 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00041 PROSITE PS01124 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01124 PSORT swissprot:RHAR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RHAR_ECOLI PSORT-B swissprot:RHAR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RHAR_ECOLI PSORT2 swissprot:RHAR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RHAR_ECOLI Pfam PF02311 http://pfam.xfam.org/family/PF02311 Pfam PF12833 http://pfam.xfam.org/family/PF12833 Phobius swissprot:RHAR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RHAR_ECOLI PhylomeDB P09378 http://phylomedb.org/?seqid=P09378 ProteinModelPortal P09378 http://www.proteinmodelportal.org/query/uniprot/P09378 PubMed 11073923 http://www.ncbi.nlm.nih.gov/pubmed/11073923 PubMed 1339463 http://www.ncbi.nlm.nih.gov/pubmed/1339463 PubMed 15342598 http://www.ncbi.nlm.nih.gov/pubmed/15342598 PubMed 1551902 http://www.ncbi.nlm.nih.gov/pubmed/1551902 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3316663 http://www.ncbi.nlm.nih.gov/pubmed/3316663 PubMed 8230210 http://www.ncbi.nlm.nih.gov/pubmed/8230210 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 8757746 http://www.ncbi.nlm.nih.gov/pubmed/8757746 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418342 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418342 RefSeq WP_001336056 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001336056 SMART SM00342 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00342 SMR P09378 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P09378 STRING 511145.b3906 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3906&targetmode=cogs STRING COG2207 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2207&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF51182 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51182 UniProtKB RHAR_ECOLI http://www.uniprot.org/uniprot/RHAR_ECOLI UniProtKB-AC P09378 http://www.uniprot.org/uniprot/P09378 charge swissprot:RHAR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RHAR_ECOLI eggNOG ENOG4108BRW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108BRW eggNOG ENOG410XYX0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XYX0 epestfind swissprot:RHAR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RHAR_ECOLI garnier swissprot:RHAR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RHAR_ECOLI helixturnhelix swissprot:RHAR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RHAR_ECOLI hmoment swissprot:RHAR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RHAR_ECOLI iep swissprot:RHAR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RHAR_ECOLI inforesidue swissprot:RHAR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RHAR_ECOLI octanol swissprot:RHAR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RHAR_ECOLI pepcoil swissprot:RHAR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RHAR_ECOLI pepdigest swissprot:RHAR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RHAR_ECOLI pepinfo swissprot:RHAR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RHAR_ECOLI pepnet swissprot:RHAR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RHAR_ECOLI pepstats swissprot:RHAR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RHAR_ECOLI pepwheel swissprot:RHAR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RHAR_ECOLI pepwindow swissprot:RHAR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RHAR_ECOLI sigcleave swissprot:RHAR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RHAR_ECOLI ## Database ID URL or Descriptions # BioGrid 4259472 9 # EcoGene EG12862 uspC # FUNCTION USPC_ECOLI Required for resistance to DNA-damaging agents. {ECO 0000269|PubMed 11849540}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0032947 protein complex scaffold; IDA:EcoCyc. # GO_process GO:0009651 response to salt stress; IMP:CACAO. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0005198 structural molecule activity # GOslim_process GO:0006950 response to stress # Gene3D 3.40.50.620 -; 1. # INDUCTION During growth inhibition caused by the exhaustion of any of a variety of nutrients (carbon, nitrogen, phosphate, sulfate, required amino acid) or by the presence of a variety of toxic agents. Positively regulated by guanosine 3',5'-bisphosphate (ppGpp) and by a RecA/FtsK-dependent regulatory pathway. {ECO:0000269|PubMed 11849540}. # IntAct P46888 11 # InterPro IPR006015 Universal_stress_UspA # InterPro IPR006016 UspA # InterPro IPR014729 Rossmann-like_a/b/a_fold # Organism USPC_ECOLI Escherichia coli (strain K12) # PATRIC 32119117 VBIEscCol129921_1976 # PIR G64952 G64952 # PIRSF PIRSF006276 UspA # Pfam PF00582 Usp # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName USPC_ECOLI Universal stress protein C # RefSeq NP_416409 NC_000913.3 # RefSeq WP_000122416 NZ_LN832404.1 # SIMILARITY Belongs to the universal stress protein A family. {ECO 0000305}. # SUBCELLULAR LOCATION USPC_ECOLI Cytoplasm {ECO 0000250}. # eggNOG COG0589 LUCA # eggNOG ENOG4108VA4 Bacteria BLAST swissprot:USPC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:USPC_ECOLI BioCyc ECOL316407:JW1884-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1884-MONOMER BioCyc EcoCyc:G7031-MONOMER http://biocyc.org/getid?id=EcoCyc:G7031-MONOMER COG COG0589 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0589 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2002.02720.x http://dx.doi.org/10.1046/j.1365-2958.2002.02720.x DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U27211 http://www.ebi.ac.uk/ena/data/view/U27211 EchoBASE EB2704 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2704 EcoGene EG12862 http://www.ecogene.org/geneInfo.php?eg_id=EG12862 EnsemblBacteria AAC74965 http://www.ensemblgenomes.org/id/AAC74965 EnsemblBacteria AAC74965 http://www.ensemblgenomes.org/id/AAC74965 EnsemblBacteria BAA15716 http://www.ensemblgenomes.org/id/BAA15716 EnsemblBacteria BAA15716 http://www.ensemblgenomes.org/id/BAA15716 EnsemblBacteria BAA15716 http://www.ensemblgenomes.org/id/BAA15716 EnsemblBacteria b1895 http://www.ensemblgenomes.org/id/b1895 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0032947 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032947 GO_process GO:0009651 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009651 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0005198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005198 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 GeneID 946404 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946404 HOGENOM HOG000238899 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000238899&db=HOGENOM6 InParanoid P46888 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P46888 IntAct P46888 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P46888* InterPro IPR006015 http://www.ebi.ac.uk/interpro/entry/IPR006015 InterPro IPR006016 http://www.ebi.ac.uk/interpro/entry/IPR006016 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 KEGG_Gene ecj:JW1884 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1884 KEGG_Gene eco:b1895 http://www.genome.jp/dbget-bin/www_bget?eco:b1895 KEGG_Orthology KO:K14064 http://www.genome.jp/dbget-bin/www_bget?KO:K14064 OMA CGNHNQS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CGNHNQS PSORT swissprot:USPC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:USPC_ECOLI PSORT-B swissprot:USPC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:USPC_ECOLI PSORT2 swissprot:USPC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:USPC_ECOLI Pfam PF00582 http://pfam.xfam.org/family/PF00582 Phobius swissprot:USPC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:USPC_ECOLI PhylomeDB P46888 http://phylomedb.org/?seqid=P46888 ProteinModelPortal P46888 http://www.proteinmodelportal.org/query/uniprot/P46888 PubMed 11849540 http://www.ncbi.nlm.nih.gov/pubmed/11849540 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416409 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416409 RefSeq WP_000122416 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000122416 SMR P46888 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P46888 STRING 511145.b1895 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1895&targetmode=cogs STRING COG0589 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0589&targetmode=cogs UniProtKB USPC_ECOLI http://www.uniprot.org/uniprot/USPC_ECOLI UniProtKB-AC P46888 http://www.uniprot.org/uniprot/P46888 charge swissprot:USPC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:USPC_ECOLI eggNOG COG0589 http://eggnogapi.embl.de/nog_data/html/tree/COG0589 eggNOG ENOG4108VA4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108VA4 epestfind swissprot:USPC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:USPC_ECOLI garnier swissprot:USPC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:USPC_ECOLI helixturnhelix swissprot:USPC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:USPC_ECOLI hmoment swissprot:USPC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:USPC_ECOLI iep swissprot:USPC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:USPC_ECOLI inforesidue swissprot:USPC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:USPC_ECOLI octanol swissprot:USPC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:USPC_ECOLI pepcoil swissprot:USPC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:USPC_ECOLI pepdigest swissprot:USPC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:USPC_ECOLI pepinfo swissprot:USPC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:USPC_ECOLI pepnet swissprot:USPC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:USPC_ECOLI pepstats swissprot:USPC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:USPC_ECOLI pepwheel swissprot:USPC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:USPC_ECOLI pepwindow swissprot:USPC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:USPC_ECOLI sigcleave swissprot:USPC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:USPC_ECOLI ## Database ID URL or Descriptions # AltName YMGE_ECOLI Transglycosylase-associated gene protein # BioGrid 4262916 114 # EcoGene EG14338 ymgE # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR007341 Transgly_assoc # Organism YMGE_ECOLI Escherichia coli (strain K12) # PATRIC 32117638 VBIEscCol129921_1241 # PIR H64865 H64865 # Pfam PF04226 Transgly_assoc # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YMGE_ECOLI UPF0410 protein ymge # RefSeq NP_415713 NC_000913.3 # RefSeq WP_001310727 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0410 family. {ECO 0000305}. # SUBCELLULAR LOCATION YMGE_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # eggNOG COG2261 LUCA # eggNOG ENOG4105Y3U Bacteria BLAST swissprot:YMGE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YMGE_ECOLI BioCyc ECOL316407:JW1184-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1184-MONOMER BioCyc EcoCyc:G6624-MONOMER http://biocyc.org/getid?id=EcoCyc:G6624-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4084 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4084 EcoGene EG14338 http://www.ecogene.org/geneInfo.php?eg_id=EG14338 EnsemblBacteria AAC74279 http://www.ensemblgenomes.org/id/AAC74279 EnsemblBacteria AAC74279 http://www.ensemblgenomes.org/id/AAC74279 EnsemblBacteria BAA36053 http://www.ensemblgenomes.org/id/BAA36053 EnsemblBacteria BAA36053 http://www.ensemblgenomes.org/id/BAA36053 EnsemblBacteria BAA36053 http://www.ensemblgenomes.org/id/BAA36053 EnsemblBacteria b1195 http://www.ensemblgenomes.org/id/b1195 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 945760 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945760 HOGENOM HOG000281220 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000281220&db=HOGENOM6 InParanoid P76011 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76011 InterPro IPR007341 http://www.ebi.ac.uk/interpro/entry/IPR007341 KEGG_Gene ecj:JW1184 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1184 KEGG_Gene eco:b1195 http://www.genome.jp/dbget-bin/www_bget?eco:b1195 OMA FFQTCIL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FFQTCIL PSORT swissprot:YMGE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YMGE_ECOLI PSORT-B swissprot:YMGE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YMGE_ECOLI PSORT2 swissprot:YMGE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YMGE_ECOLI Pfam PF04226 http://pfam.xfam.org/family/PF04226 Phobius swissprot:YMGE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YMGE_ECOLI PhylomeDB P76011 http://phylomedb.org/?seqid=P76011 ProteinModelPortal P76011 http://www.proteinmodelportal.org/query/uniprot/P76011 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415713 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415713 RefSeq WP_001310727 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001310727 STRING 511145.b1195 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1195&targetmode=cogs UniProtKB YMGE_ECOLI http://www.uniprot.org/uniprot/YMGE_ECOLI UniProtKB-AC P76011 http://www.uniprot.org/uniprot/P76011 charge swissprot:YMGE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YMGE_ECOLI eggNOG COG2261 http://eggnogapi.embl.de/nog_data/html/tree/COG2261 eggNOG ENOG4105Y3U http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105Y3U epestfind swissprot:YMGE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YMGE_ECOLI garnier swissprot:YMGE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YMGE_ECOLI helixturnhelix swissprot:YMGE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YMGE_ECOLI hmoment swissprot:YMGE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YMGE_ECOLI iep swissprot:YMGE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YMGE_ECOLI inforesidue swissprot:YMGE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YMGE_ECOLI octanol swissprot:YMGE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YMGE_ECOLI pepcoil swissprot:YMGE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YMGE_ECOLI pepdigest swissprot:YMGE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YMGE_ECOLI pepinfo swissprot:YMGE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YMGE_ECOLI pepnet swissprot:YMGE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YMGE_ECOLI pepstats swissprot:YMGE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YMGE_ECOLI pepwheel swissprot:YMGE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YMGE_ECOLI pepwindow swissprot:YMGE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YMGE_ECOLI sigcleave swissprot:YMGE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YMGE_ECOLI ## Database ID URL or Descriptions # BioGrid 4262944 4 # EcoGene EG12527 yjgH # Gene3D 3.30.1330.40 -; 1. # InterPro IPR006175 YjgF/YER057c/UK114 # InterPro IPR013813 Endoribo_LPSP/chorism_mut-like # Organism YJGH_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11803 PTHR11803 # PATRIC 32124069 VBIEscCol129921_4379 # PDB 1PF5 X-ray; 2.50 A; A=1-131 # PIR S56474 S56474 # Pfam PF01042 Ribonuc_L-PSP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJGH_ECOLI RutC family protein YjgH # RefSeq NP_418669 NC_000913.3 # RefSeq WP_000230281 NZ_LN832404.1 # SIMILARITY Belongs to the RutC family. {ECO 0000305}. # SUPFAM SSF55298 SSF55298 # eggNOG COG0251 LUCA # eggNOG ENOG4108UQ8 Bacteria BLAST swissprot:YJGH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJGH_ECOLI BioCyc ECOL316407:JW4206-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4206-MONOMER BioCyc EcoCyc:G7879-MONOMER http://biocyc.org/getid?id=EcoCyc:G7879-MONOMER DIP DIP-12603N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12603N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2417 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2417 EcoGene EG12527 http://www.ecogene.org/geneInfo.php?eg_id=EG12527 EnsemblBacteria AAC77205 http://www.ensemblgenomes.org/id/AAC77205 EnsemblBacteria AAC77205 http://www.ensemblgenomes.org/id/AAC77205 EnsemblBacteria BAE78246 http://www.ensemblgenomes.org/id/BAE78246 EnsemblBacteria BAE78246 http://www.ensemblgenomes.org/id/BAE78246 EnsemblBacteria BAE78246 http://www.ensemblgenomes.org/id/BAE78246 EnsemblBacteria b4248 http://www.ensemblgenomes.org/id/b4248 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.30.1330.40 http://www.cathdb.info/version/latest/superfamily/3.30.1330.40 GeneID 948769 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948769 HOGENOM HOG000267215 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267215&db=HOGENOM6 InParanoid P39332 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39332 IntAct P39332 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39332* InterPro IPR006175 http://www.ebi.ac.uk/interpro/entry/IPR006175 InterPro IPR013813 http://www.ebi.ac.uk/interpro/entry/IPR013813 KEGG_Gene ecj:JW4206 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4206 KEGG_Gene eco:b4248 http://www.genome.jp/dbget-bin/www_bget?eco:b4248 MINT MINT-1305302 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1305302 OMA VGVNWLA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VGVNWLA PANTHER PTHR11803 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11803 PDB 1PF5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1PF5 PDBsum 1PF5 http://www.ebi.ac.uk/pdbsum/1PF5 PSORT swissprot:YJGH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJGH_ECOLI PSORT-B swissprot:YJGH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJGH_ECOLI PSORT2 swissprot:YJGH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJGH_ECOLI Pfam PF01042 http://pfam.xfam.org/family/PF01042 Phobius swissprot:YJGH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJGH_ECOLI PhylomeDB P39332 http://phylomedb.org/?seqid=P39332 ProteinModelPortal P39332 http://www.proteinmodelportal.org/query/uniprot/P39332 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418669 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418669 RefSeq WP_000230281 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000230281 SMR P39332 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39332 STRING 511145.b4248 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4248&targetmode=cogs SUPFAM SSF55298 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55298 UniProtKB YJGH_ECOLI http://www.uniprot.org/uniprot/YJGH_ECOLI UniProtKB-AC P39332 http://www.uniprot.org/uniprot/P39332 charge swissprot:YJGH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJGH_ECOLI eggNOG COG0251 http://eggnogapi.embl.de/nog_data/html/tree/COG0251 eggNOG ENOG4108UQ8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UQ8 epestfind swissprot:YJGH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJGH_ECOLI garnier swissprot:YJGH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJGH_ECOLI helixturnhelix swissprot:YJGH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJGH_ECOLI hmoment swissprot:YJGH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJGH_ECOLI iep swissprot:YJGH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJGH_ECOLI inforesidue swissprot:YJGH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJGH_ECOLI octanol swissprot:YJGH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJGH_ECOLI pepcoil swissprot:YJGH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJGH_ECOLI pepdigest swissprot:YJGH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJGH_ECOLI pepinfo swissprot:YJGH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJGH_ECOLI pepnet swissprot:YJGH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJGH_ECOLI pepstats swissprot:YJGH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJGH_ECOLI pepwheel swissprot:YJGH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJGH_ECOLI pepwindow swissprot:YJGH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJGH_ECOLI sigcleave swissprot:YJGH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJGH_ECOLI ## Database ID URL or Descriptions # AltName RZOD_ECOLI Outer membrane lipoprotein Rz1 from lambdoid prophage DLP12 # AltName RZOD_ECOLI Spanin from lambdoid prophage DLP12, outer membrane subunit # BioGrid 4259886 8 # EcoGene EG14380 rzoD # FUNCTION RZOD_ECOLI Component of the spanin complex that disrupts the outer membrane and causes cell lysis during virus exit. The spanin complex conducts the final step in cell lysis by disrupting the outer membrane after holin and endolysin action have permeabilized the inner membrane and degraded the host peptidoglycans (By similarity). {ECO 0000250}. # GO_component GO:0009279 cell outer membrane; IEA:UniProtKB-SubCell. # GO_process GO:0019076 viral release from host cell; IEA:UniProtKB-KW. # GO_process GO:0019835 cytolysis; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0008150 biological_process # GOslim_process GO:0040011 locomotion # GOslim_process GO:0044403 symbiosis, encompassing mutualism through parasitism # InterPro IPR010346 o-spanin # MISCELLANEOUS RZOD_ECOLI Encoded by the cryptic lambdoid prophage DLP12. # Organism RZOD_ECOLI Escherichia coli (strain K12) # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF06085 Rz1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Prophage outer membrane lipoprotein RzoD {ECO 0000305} # RefSeq YP_588440 NC_000913.3 # SIMILARITY Belongs to the lambdalikevirus o-spanin family. {ECO 0000305}. # SUBCELLULAR LOCATION RZOD_ECOLI Cell outer membrane {ECO 0000250}; Lipid- anchor {ECO 0000255|PROSITE-ProRule PRU00303}; Periplasmic side {ECO 0000250}. # SUBUNIT Homodimer; disulfide-linked. Interacts (via C-terminus) with RZ (via C-terminus). Part of the spanin complex which spans the entire periplasmic space. The spanin complex is composed of spanin, inner membrane subunit and spanin, outer membrane subunit (By similarity). {ECO 0000250}. BLAST swissprot:RZOD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RZOD_ECOLI BioCyc ECOL316407:JW5080-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5080-MONOMER BioCyc EcoCyc:MONOMER0-2658 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2658 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14380 http://www.ecogene.org/geneInfo.php?eg_id=EG14380 EnsemblBacteria ABD18640 http://www.ensemblgenomes.org/id/ABD18640 EnsemblBacteria ABD18640 http://www.ensemblgenomes.org/id/ABD18640 EnsemblBacteria BAE76332 http://www.ensemblgenomes.org/id/BAE76332 EnsemblBacteria BAE76332 http://www.ensemblgenomes.org/id/BAE76332 EnsemblBacteria BAE76332 http://www.ensemblgenomes.org/id/BAE76332 EnsemblBacteria b4510 http://www.ensemblgenomes.org/id/b4510 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_process GO:0019076 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019076 GO_process GO:0019835 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019835 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0040011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011 GOslim_process GO:0044403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403 GeneID 1450242 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1450242 HOGENOM HOG000054872 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000054872&db=HOGENOM6 InterPro IPR010346 http://www.ebi.ac.uk/interpro/entry/IPR010346 KEGG_Gene ecj:JW5080 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5080 KEGG_Gene eco:b4510 http://www.genome.jp/dbget-bin/www_bget?eco:b4510 OMA PVQVPCV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PVQVPCV PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:RZOD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RZOD_ECOLI PSORT-B swissprot:RZOD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RZOD_ECOLI PSORT2 swissprot:RZOD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RZOD_ECOLI Pfam PF06085 http://pfam.xfam.org/family/PF06085 Phobius swissprot:RZOD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RZOD_ECOLI ProteinModelPortal P58041 http://www.proteinmodelportal.org/query/uniprot/P58041 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq YP_588440 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_588440 STRING 511145.b4510 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4510&targetmode=cogs UniProtKB RZOD_ECOLI http://www.uniprot.org/uniprot/RZOD_ECOLI UniProtKB-AC P58041 http://www.uniprot.org/uniprot/P58041 charge swissprot:RZOD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RZOD_ECOLI epestfind swissprot:RZOD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RZOD_ECOLI garnier swissprot:RZOD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RZOD_ECOLI helixturnhelix swissprot:RZOD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RZOD_ECOLI hmoment swissprot:RZOD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RZOD_ECOLI iep swissprot:RZOD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RZOD_ECOLI inforesidue swissprot:RZOD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RZOD_ECOLI octanol swissprot:RZOD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RZOD_ECOLI pepcoil swissprot:RZOD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RZOD_ECOLI pepdigest swissprot:RZOD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RZOD_ECOLI pepinfo swissprot:RZOD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RZOD_ECOLI pepnet swissprot:RZOD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RZOD_ECOLI pepstats swissprot:RZOD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RZOD_ECOLI pepwheel swissprot:RZOD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RZOD_ECOLI pepwindow swissprot:RZOD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RZOD_ECOLI sigcleave swissprot:RZOD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RZOD_ECOLI ## Database ID URL or Descriptions # AltName PHR_ECOLI DNA photolyase # AltName PHR_ECOLI Photoreactivating enzyme # BIOPHYSICOCHEMICAL PROPERTIES Absorption Abs(max)=384 nm; # BRENDA 4.1.99 2026 # BioGrid 4259920 163 # CATALYTIC ACTIVITY PHR_ECOLI Cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). # COFACTOR Name=5,10-methylenetetrahydrofolate; Xref=ChEBI:CHEBI 12071; Note=Binds 1 5,10-methenyltetrahydrofolate non-covalently per subunit.; # COFACTOR Name=FAD; Xref=ChEBI:CHEBI 57692; Note=Binds 1 FAD per subunit.; # DrugBank DB03147 Flavin adenine dinucleotide # EcoGene EG10736 phrB # FUNCTION PHR_ECOLI Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation. # GO_function GO:0000166 nucleotide binding; IEA:UniProtKB-KW. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003904 deoxyribodipyrimidine photo-lyase activity; IDA:EcoCyc. # GO_process GO:0006281 DNA repair; IEA:UniProtKB-KW. # GO_process GO:0018298 protein-chromophore linkage; IDA:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0006950 response to stress # Gene3D 3.40.50.620 -; 1. # IntAct P00914 11 # InterPro IPR002081 Cryptochrome/DNA_photolyase_1 # InterPro IPR005101 Cryptochr/Photolyase_FAD-bd # InterPro IPR006050 DNA_photolyase_N # InterPro IPR014729 Rossmann-like_a/b/a_fold # InterPro IPR018394 DNA_photolyase_1_CS_C # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # MISCELLANEOUS PHR_ECOLI There are only 10-20 molecules of photolyase per E.coli cell. # MISCELLANEOUS PHR_ECOLI Upon absorption of visible light electrons are transferred from Trp-307 through Trp-360 to Trp 383, and from there to FADH, giving rise to the fully reduced catalytic FADH(-). # Organism PHR_ECOLI Escherichia coli (strain K12) # PATRIC 32116611 VBIEscCol129921_0738 # PDB 1DNP X-ray; 2.30 A; A/B=2-472 # PIR A01137 WZECD # PRINTS PR00147 DNAPHOTLYASE # PROSITE PS00394 DNA_PHOTOLYASES_1_1 # PROSITE PS00691 DNA_PHOTOLYASES_1_2 # PROSITE PS51645 PHR_CRY_ALPHA_BETA # Pfam PF00875 DNA_photolyase # Pfam PF03441 FAD_binding_7 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PHR_ECOLI Deoxyribodipyrimidine photo-lyase # RefSeq NP_415236 NC_000913.3 # RefSeq WP_000207142 NZ_LN832404.1 # SIMILARITY Belongs to the DNA photolyase class-1 family. {ECO 0000305}. # SIMILARITY Contains 1 photolyase/cryptochrome alpha/beta domain. {ECO 0000305}. # SUBUNIT Monomer. {ECO:0000269|PubMed 7604260}. # SUPFAM SSF48173 SSF48173 # SUPFAM SSF52425 SSF52425 # eggNOG COG0415 LUCA # eggNOG ENOG4105CVP Bacteria BLAST swissprot:PHR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PHR_ECOLI BioCyc ECOL316407:JW0698-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0698-MONOMER BioCyc EcoCyc:EG10736-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10736-MONOMER BioCyc MetaCyc:EG10736-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10736-MONOMER COG COG0415 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0415 DIP DIP-10505N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10505N DOI 10.1016/j.bbabio.2004.02.010 http://dx.doi.org/10.1016/j.bbabio.2004.02.010 DOI 10.1021/bi00476a009 http://dx.doi.org/10.1021/bi00476a009 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.1531645100 http://dx.doi.org/10.1073/pnas.1531645100 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1126/science.7604260 http://dx.doi.org/10.1126/science.7604260 DrugBank DB03147 http://www.drugbank.ca/drugs/DB03147 EC_number EC:4.1.99.3 http://www.genome.jp/dbget-bin/www_bget?EC:4.1.99.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K01299 http://www.ebi.ac.uk/ena/data/view/K01299 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X57399 http://www.ebi.ac.uk/ena/data/view/X57399 ENZYME 4.1.99.3 http://enzyme.expasy.org/EC/4.1.99.3 EchoBASE EB0729 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0729 EcoGene EG10736 http://www.ecogene.org/geneInfo.php?eg_id=EG10736 EnsemblBacteria AAC73802 http://www.ensemblgenomes.org/id/AAC73802 EnsemblBacteria AAC73802 http://www.ensemblgenomes.org/id/AAC73802 EnsemblBacteria BAA35367 http://www.ensemblgenomes.org/id/BAA35367 EnsemblBacteria BAA35367 http://www.ensemblgenomes.org/id/BAA35367 EnsemblBacteria BAA35367 http://www.ensemblgenomes.org/id/BAA35367 EnsemblBacteria b0708 http://www.ensemblgenomes.org/id/b0708 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000166 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000166 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003904 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003904 GO_process GO:0006281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006281 GO_process GO:0018298 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018298 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 GeneID 947005 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947005 HOGENOM HOG000245621 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000245621&db=HOGENOM6 InParanoid P00914 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00914 IntAct P00914 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00914* IntEnz 4.1.99.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.99.3 InterPro IPR002081 http://www.ebi.ac.uk/interpro/entry/IPR002081 InterPro IPR005101 http://www.ebi.ac.uk/interpro/entry/IPR005101 InterPro IPR006050 http://www.ebi.ac.uk/interpro/entry/IPR006050 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 InterPro IPR018394 http://www.ebi.ac.uk/interpro/entry/IPR018394 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW0698 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0698 KEGG_Gene eco:b0708 http://www.genome.jp/dbget-bin/www_bget?eco:b0708 KEGG_Orthology KO:K01669 http://www.genome.jp/dbget-bin/www_bget?KO:K01669 MINT MINT-1302006 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1302006 OMA WGERYFR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WGERYFR PDB 1DNP http://www.ebi.ac.uk/pdbe-srv/view/entry/1DNP PDBsum 1DNP http://www.ebi.ac.uk/pdbsum/1DNP PRINTS PR00147 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00147 PROSITE PS00394 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00394 PROSITE PS00691 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00691 PROSITE PS51645 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51645 PSORT swissprot:PHR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PHR_ECOLI PSORT-B swissprot:PHR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PHR_ECOLI PSORT2 swissprot:PHR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PHR_ECOLI Pfam PF00875 http://pfam.xfam.org/family/PF00875 Pfam PF03441 http://pfam.xfam.org/family/PF03441 Phobius swissprot:PHR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PHR_ECOLI PhylomeDB P00914 http://phylomedb.org/?seqid=P00914 ProteinModelPortal P00914 http://www.proteinmodelportal.org/query/uniprot/P00914 PubMed 12835419 http://www.ncbi.nlm.nih.gov/pubmed/12835419 PubMed 15721603 http://www.ncbi.nlm.nih.gov/pubmed/15721603 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2200511 http://www.ncbi.nlm.nih.gov/pubmed/2200511 PubMed 6325460 http://www.ncbi.nlm.nih.gov/pubmed/6325460 PubMed 7604260 http://www.ncbi.nlm.nih.gov/pubmed/7604260 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415236 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415236 RefSeq WP_000207142 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000207142 SMR P00914 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00914 STRING 511145.b0708 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0708&targetmode=cogs STRING COG0415 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0415&targetmode=cogs SUPFAM SSF48173 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48173 SUPFAM SSF52425 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52425 UniProtKB PHR_ECOLI http://www.uniprot.org/uniprot/PHR_ECOLI UniProtKB-AC P00914 http://www.uniprot.org/uniprot/P00914 charge swissprot:PHR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PHR_ECOLI eggNOG COG0415 http://eggnogapi.embl.de/nog_data/html/tree/COG0415 eggNOG ENOG4105CVP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CVP epestfind swissprot:PHR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PHR_ECOLI garnier swissprot:PHR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PHR_ECOLI helixturnhelix swissprot:PHR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PHR_ECOLI hmoment swissprot:PHR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PHR_ECOLI iep swissprot:PHR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PHR_ECOLI inforesidue swissprot:PHR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PHR_ECOLI octanol swissprot:PHR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PHR_ECOLI pepcoil swissprot:PHR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PHR_ECOLI pepdigest swissprot:PHR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PHR_ECOLI pepinfo swissprot:PHR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PHR_ECOLI pepnet swissprot:PHR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PHR_ECOLI pepstats swissprot:PHR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PHR_ECOLI pepwheel swissprot:PHR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PHR_ECOLI pepwindow swissprot:PHR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PHR_ECOLI sigcleave swissprot:PHR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PHR_ECOLI ## Database ID URL or Descriptions # BioGrid 4262757 5 # EcoGene EG12574 yjiM # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_process GO:0006950 response to stress # InterPro IPR010327 FldB/FldC_alpha/beta # Organism YJIM_ECOLI Escherichia coli (strain K12) # PATRIC 32124276 VBIEscCol129921_4481 # PIR S56560 S56560 # Pfam PF06050 HGD-D # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJIM_ECOLI Uncharacterized protein YjiM # RefSeq NP_418755 NC_000913.3 # RefSeq WP_001300012 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97231.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the FldB/FldC dehydratase beta subunit family. {ECO 0000305}. # eggNOG COG1775 LUCA # eggNOG ENOG4105DCU Bacteria BLAST swissprot:YJIM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJIM_ECOLI BioCyc ECOL316407:JW5786-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5786-MONOMER BioCyc EcoCyc:G7932-MONOMER http://biocyc.org/getid?id=EcoCyc:G7932-MONOMER DIP DIP-12639N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12639N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2462 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2462 EcoGene EG12574 http://www.ecogene.org/geneInfo.php?eg_id=EG12574 EnsemblBacteria AAC77291 http://www.ensemblgenomes.org/id/AAC77291 EnsemblBacteria AAC77291 http://www.ensemblgenomes.org/id/AAC77291 EnsemblBacteria BAE78328 http://www.ensemblgenomes.org/id/BAE78328 EnsemblBacteria BAE78328 http://www.ensemblgenomes.org/id/BAE78328 EnsemblBacteria BAE78328 http://www.ensemblgenomes.org/id/BAE78328 EnsemblBacteria b4335 http://www.ensemblgenomes.org/id/b4335 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 945789 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945789 HOGENOM HOG000282745 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000282745&db=HOGENOM6 InParanoid P39384 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39384 IntAct P39384 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39384* InterPro IPR010327 http://www.ebi.ac.uk/interpro/entry/IPR010327 KEGG_Gene ecj:JW5786 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5786 KEGG_Gene eco:b4335 http://www.genome.jp/dbget-bin/www_bget?eco:b4335 OMA CPYMYFS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CPYMYFS PSORT swissprot:YJIM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJIM_ECOLI PSORT-B swissprot:YJIM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJIM_ECOLI PSORT2 swissprot:YJIM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJIM_ECOLI Pfam PF06050 http://pfam.xfam.org/family/PF06050 Phobius swissprot:YJIM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJIM_ECOLI PhylomeDB P39384 http://phylomedb.org/?seqid=P39384 ProteinModelPortal P39384 http://www.proteinmodelportal.org/query/uniprot/P39384 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418755 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418755 RefSeq WP_001300012 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300012 SMR P39384 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39384 STRING 511145.b4335 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4335&targetmode=cogs UniProtKB YJIM_ECOLI http://www.uniprot.org/uniprot/YJIM_ECOLI UniProtKB-AC P39384 http://www.uniprot.org/uniprot/P39384 charge swissprot:YJIM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJIM_ECOLI eggNOG COG1775 http://eggnogapi.embl.de/nog_data/html/tree/COG1775 eggNOG ENOG4105DCU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DCU epestfind swissprot:YJIM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJIM_ECOLI garnier swissprot:YJIM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJIM_ECOLI helixturnhelix swissprot:YJIM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJIM_ECOLI hmoment swissprot:YJIM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJIM_ECOLI iep swissprot:YJIM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJIM_ECOLI inforesidue swissprot:YJIM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJIM_ECOLI octanol swissprot:YJIM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJIM_ECOLI pepcoil swissprot:YJIM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJIM_ECOLI pepdigest swissprot:YJIM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJIM_ECOLI pepinfo swissprot:YJIM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJIM_ECOLI pepnet swissprot:YJIM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJIM_ECOLI pepstats swissprot:YJIM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJIM_ECOLI pepwheel swissprot:YJIM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJIM_ECOLI pepwindow swissprot:YJIM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJIM_ECOLI sigcleave swissprot:YJIM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJIM_ECOLI ## Database ID URL or Descriptions # AltName PTPB2_ECOLI EIIB-Aga' # AltName PTPB2_ECOLI PTS system N-acetylgalactosamine-specific EIIB component 2 # BioGrid 4261156 10 # CATALYTIC ACTIVITY Protein EIIB N(pi)-phospho-L- histidine/cysteine + sugar = protein EIIB + sugar phosphate. {ECO:0000255|PROSITE-ProRule PRU00424}. # CDD cd00001 PTS_IIB_man # DOMAIN PTPB2_ECOLI The EIIB domain is phosphorylated by phospho-EIIA on a cysteinyl or histidyl residue, depending on the transported sugar. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the EIIC domain. # EcoGene EG12764 agaV # FUNCTION PTPB2_ECOLI The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylgalactosamine transport. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0008982 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:InterPro. # GO_function GO:0016301 kinase activity; IEA:UniProtKB-KW. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # Gene3D 3.40.35.10 -; 1. # IntAct P42904 2 # InterPro IPR004720 PTS_IIB_sorbose-sp # InterPro IPR018455 PTS_IIB_sorbose-sp_subgr # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00277 PTS system, N-acetylgalactosamine-specific II component # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko00052 Galactose metabolism # KEGG_Pathway ko02060 Phosphotransferase system (PTS) # Organism PTPB2_ECOLI Escherichia coli (strain K12) # PATRIC 32121682 VBIEscCol129921_3227 # PROSITE PS51101 PTS_EIIB_TYPE_4 # Pfam PF03830 PTSIIB_sorb # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PTPB2_ECOLI N-acetylgalactosamine-specific phosphotransferase enzyme IIB component 2 # RefSeq NP_417602 NC_000913.3 # RefSeq WP_001336162 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA57936.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Contains 1 PTS EIIB type-4 domain. {ECO:0000255|PROSITE-ProRule PRU00424}. # SUBCELLULAR LOCATION PTPB2_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF52728 SSF52728 # TIGRFAMs TIGR00854 pts-sorbose # eggNOG COG3444 LUCA # eggNOG ENOG4108RG5 Bacteria BLAST swissprot:PTPB2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTPB2_ECOLI BioCyc ECOL316407:JW3102-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3102-MONOMER BioCyc EcoCyc:G7632-MONOMER http://biocyc.org/getid?id=EcoCyc:G7632-MONOMER COG COG3444 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3444 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1099/13500872-142-2-231 http://dx.doi.org/10.1099/13500872-142-2-231 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 2.7.1.- http://enzyme.expasy.org/EC/2.7.1.- EchoBASE EB2617 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2617 EcoGene EG12764 http://www.ecogene.org/geneInfo.php?eg_id=EG12764 EnsemblBacteria AAC76167 http://www.ensemblgenomes.org/id/AAC76167 EnsemblBacteria AAC76167 http://www.ensemblgenomes.org/id/AAC76167 EnsemblBacteria BAE77180 http://www.ensemblgenomes.org/id/BAE77180 EnsemblBacteria BAE77180 http://www.ensemblgenomes.org/id/BAE77180 EnsemblBacteria BAE77180 http://www.ensemblgenomes.org/id/BAE77180 EnsemblBacteria b3133 http://www.ensemblgenomes.org/id/b3133 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0008982 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008982 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.40.35.10 http://www.cathdb.info/version/latest/superfamily/3.40.35.10 GeneID 947648 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947648 HOGENOM HOG000096437 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000096437&db=HOGENOM6 InParanoid P42904 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P42904 IntAct P42904 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P42904* IntEnz 2.7.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1 InterPro IPR004720 http://www.ebi.ac.uk/interpro/entry/IPR004720 InterPro IPR018455 http://www.ebi.ac.uk/interpro/entry/IPR018455 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3102 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3102 KEGG_Gene eco:b3133 http://www.genome.jp/dbget-bin/www_bget?eco:b3133 KEGG_Orthology KO:K02745 http://www.genome.jp/dbget-bin/www_bget?KO:K02745 KEGG_Pathway ko00052 http://www.genome.jp/kegg-bin/show_pathway?ko00052 KEGG_Pathway ko02060 http://www.genome.jp/kegg-bin/show_pathway?ko02060 KEGG_Reaction rn:R08366 http://www.genome.jp/dbget-bin/www_bget?rn:R08366 OMA LVCKSPA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LVCKSPA PROSITE PS51101 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51101 PSORT swissprot:PTPB2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTPB2_ECOLI PSORT-B swissprot:PTPB2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTPB2_ECOLI PSORT2 swissprot:PTPB2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTPB2_ECOLI Pfam PF03830 http://pfam.xfam.org/family/PF03830 Phobius swissprot:PTPB2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTPB2_ECOLI PhylomeDB P42904 http://phylomedb.org/?seqid=P42904 ProteinModelPortal P42904 http://www.proteinmodelportal.org/query/uniprot/P42904 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8932697 http://www.ncbi.nlm.nih.gov/pubmed/8932697 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417602 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417602 RefSeq WP_001336162 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001336162 SMR P42904 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P42904 STRING 511145.b3133 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3133&targetmode=cogs STRING COG3444 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3444&targetmode=cogs SUPFAM SSF52728 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52728 TIGRFAMs TIGR00854 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00854 UniProtKB PTPB2_ECOLI http://www.uniprot.org/uniprot/PTPB2_ECOLI UniProtKB-AC P42904 http://www.uniprot.org/uniprot/P42904 charge swissprot:PTPB2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTPB2_ECOLI eggNOG COG3444 http://eggnogapi.embl.de/nog_data/html/tree/COG3444 eggNOG ENOG4108RG5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108RG5 epestfind swissprot:PTPB2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTPB2_ECOLI garnier swissprot:PTPB2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTPB2_ECOLI helixturnhelix swissprot:PTPB2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTPB2_ECOLI hmoment swissprot:PTPB2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTPB2_ECOLI iep swissprot:PTPB2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTPB2_ECOLI inforesidue swissprot:PTPB2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTPB2_ECOLI octanol swissprot:PTPB2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTPB2_ECOLI pepcoil swissprot:PTPB2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTPB2_ECOLI pepdigest swissprot:PTPB2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTPB2_ECOLI pepinfo swissprot:PTPB2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTPB2_ECOLI pepnet swissprot:PTPB2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTPB2_ECOLI pepstats swissprot:PTPB2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTPB2_ECOLI pepwheel swissprot:PTPB2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTPB2_ECOLI pepwindow swissprot:PTPB2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTPB2_ECOLI sigcleave swissprot:PTPB2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTPB2_ECOLI ## Database ID URL or Descriptions # AltName YGHF_ECOLI Putative general secretion pathway C-type protein YghF # BioGrid 4261896 12 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG12990 yghF # FUNCTION YGHF_ECOLI Might be involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. {ECO 0000305}. # GO_component GO:0015627 type II protein secretion system complex; IEA:InterPro. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_function GO:0008565 protein transporter activity; IEA:InterPro. # GO_process GO:0015628 protein secretion by the type II secretion system; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043234 protein complex # GOslim_function GO:0008565 protein transporter activity # GOslim_process GO:0055085 transmembrane transport # Gene3D 2.30.42.10 -; 1. # InterPro IPR001478 PDZ # InterPro IPR001639 T2SS_protein-C # InterPro IPR024961 T2SSC_N # Organism YGHF_ECOLI Escherichia coli (strain K12) # PATRIC 48665382 VBIEscCol107702_3000 # PIR H65082 H65082 # PROSITE PS01141 T2SP_C # Pfam PF11356 T2SSC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGHF_ECOLI Putative type II secretion system C-type protein YghF # SIMILARITY Belongs to the GSP C family. {ECO 0000305}. # SUBCELLULAR LOCATION YGHF_ECOLI Periplasm {ECO 0000305}. # SUPFAM SSF50156 SSF50156 # TIGRFAMs TIGR01713 typeII_sec_gspC # eggNOG COG3031 LUCA # eggNOG ENOG4108XKW Bacteria BLAST swissprot:YGHF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGHF_ECOLI BioCyc ECOL316407:JW5484-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5484-MONOMER BioCyc EcoCyc:G7537-MONOMER http://biocyc.org/getid?id=EcoCyc:G7537-MONOMER DIP DIP-12204N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12204N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2814 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2814 EcoGene EG12990 http://www.ecogene.org/geneInfo.php?eg_id=EG12990 EnsemblBacteria BAE77031 http://www.ensemblgenomes.org/id/BAE77031 EnsemblBacteria BAE77031 http://www.ensemblgenomes.org/id/BAE77031 EnsemblBacteria BAE77031 http://www.ensemblgenomes.org/id/BAE77031 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0015627 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015627 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GO_process GO:0015628 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015628 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 2.30.42.10 http://www.cathdb.info/version/latest/superfamily/2.30.42.10 HOGENOM HOG000124892 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000124892&db=HOGENOM6 InParanoid Q46834 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46834 IntAct Q46834 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46834* InterPro IPR001478 http://www.ebi.ac.uk/interpro/entry/IPR001478 InterPro IPR001639 http://www.ebi.ac.uk/interpro/entry/IPR001639 InterPro IPR024961 http://www.ebi.ac.uk/interpro/entry/IPR024961 KEGG_Gene ecj:JW5484 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5484 OMA IANRGKQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IANRGKQ PROSITE PS01141 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01141 PSORT swissprot:YGHF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGHF_ECOLI PSORT-B swissprot:YGHF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGHF_ECOLI PSORT2 swissprot:YGHF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGHF_ECOLI Pfam PF11356 http://pfam.xfam.org/family/PF11356 Phobius swissprot:YGHF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGHF_ECOLI ProteinModelPortal Q46834 http://www.proteinmodelportal.org/query/uniprot/Q46834 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SMR Q46834 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46834 STRING 316407.85675778 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85675778&targetmode=cogs SUPFAM SSF50156 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50156 TIGRFAMs TIGR01713 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01713 UniProtKB YGHF_ECOLI http://www.uniprot.org/uniprot/YGHF_ECOLI UniProtKB-AC Q46834 http://www.uniprot.org/uniprot/Q46834 charge swissprot:YGHF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGHF_ECOLI eggNOG COG3031 http://eggnogapi.embl.de/nog_data/html/tree/COG3031 eggNOG ENOG4108XKW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108XKW epestfind swissprot:YGHF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGHF_ECOLI garnier swissprot:YGHF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGHF_ECOLI helixturnhelix swissprot:YGHF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGHF_ECOLI hmoment swissprot:YGHF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGHF_ECOLI iep swissprot:YGHF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGHF_ECOLI inforesidue swissprot:YGHF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGHF_ECOLI octanol swissprot:YGHF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGHF_ECOLI pepcoil swissprot:YGHF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGHF_ECOLI pepdigest swissprot:YGHF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGHF_ECOLI pepinfo swissprot:YGHF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGHF_ECOLI pepnet swissprot:YGHF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGHF_ECOLI pepstats swissprot:YGHF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGHF_ECOLI pepwheel swissprot:YGHF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGHF_ECOLI pepwindow swissprot:YGHF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGHF_ECOLI sigcleave swissprot:YGHF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGHF_ECOLI ## Database ID URL or Descriptions # AltName JAYE_ECOLI Putative protein JayE from lambdoid prophage e14 region # BioGrid 4262854 5 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG14254 jayE # InterPro IPR006949 Baseplate_J-like # Organism JAYE_ECOLI Escherichia coli (strain K12) # PATRIC 48661565 VBIEscCol107702_1151 # PIR E64860 E64860 # Pfam PF04865 Baseplate_J # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Putative protein JayE {ECO 0000305} # RefSeq WP_001350503 NZ_CP010440.1 # SEQUENCE CAUTION Sequence=BAA35978.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the Mu gp47/PBSX XkdT family. {ECO 0000305}. # eggNOG COG3299 LUCA # eggNOG ENOG4108T86 Bacteria BLAST swissprot:JAYE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:JAYE_ECOLI BioCyc ECOL316407:JW5170-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5170-MONOMER BioCyc EcoCyc:G6596-MONOMER http://biocyc.org/getid?id=EcoCyc:G6596-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4002 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4002 EcoGene EG14254 http://www.ecogene.org/geneInfo.php?eg_id=EG14254 EnsemblBacteria BAA35978 http://www.ensemblgenomes.org/id/BAA35978 EnsemblBacteria BAA35978 http://www.ensemblgenomes.org/id/BAA35978 EnsemblBacteria BAA35978 http://www.ensemblgenomes.org/id/BAA35978 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv HOGENOM HOG000123647 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000123647&db=HOGENOM6 InParanoid P75981 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75981 InterPro IPR006949 http://www.ebi.ac.uk/interpro/entry/IPR006949 KEGG_Gene ecj:JW5170 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5170 OMA WIAEQIL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WIAEQIL PSORT swissprot:JAYE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:JAYE_ECOLI PSORT-B swissprot:JAYE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:JAYE_ECOLI PSORT2 swissprot:JAYE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:JAYE_ECOLI Pfam PF04865 http://pfam.xfam.org/family/PF04865 Phobius swissprot:JAYE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:JAYE_ECOLI PhylomeDB P75981 http://phylomedb.org/?seqid=P75981 ProteinModelPortal P75981 http://www.proteinmodelportal.org/query/uniprot/P75981 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001350503 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001350503 STRING 316407.85674851 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85674851&targetmode=cogs UniProtKB JAYE_ECOLI http://www.uniprot.org/uniprot/JAYE_ECOLI UniProtKB-AC P75981 http://www.uniprot.org/uniprot/P75981 charge swissprot:JAYE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:JAYE_ECOLI eggNOG COG3299 http://eggnogapi.embl.de/nog_data/html/tree/COG3299 eggNOG ENOG4108T86 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108T86 epestfind swissprot:JAYE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:JAYE_ECOLI garnier swissprot:JAYE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:JAYE_ECOLI helixturnhelix swissprot:JAYE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:JAYE_ECOLI hmoment swissprot:JAYE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:JAYE_ECOLI iep swissprot:JAYE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:JAYE_ECOLI inforesidue swissprot:JAYE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:JAYE_ECOLI octanol swissprot:JAYE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:JAYE_ECOLI pepcoil swissprot:JAYE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:JAYE_ECOLI pepdigest swissprot:JAYE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:JAYE_ECOLI pepinfo swissprot:JAYE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:JAYE_ECOLI pepnet swissprot:JAYE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:JAYE_ECOLI pepstats swissprot:JAYE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:JAYE_ECOLI pepwheel swissprot:JAYE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:JAYE_ECOLI pepwindow swissprot:JAYE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:JAYE_ECOLI sigcleave swissprot:JAYE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:JAYE_ECOLI ## Database ID URL or Descriptions # AltName OTC1_ECOLI OTCase-1 # BIOPHYSICOCHEMICAL PROPERTIES OTC1_ECOLI Kinetic parameters KM=50 uM for carbamoyl phosphate {ECO 0000269|PubMed 3072022, ECO 0000269|PubMed 789338, ECO 0000269|PubMed 8845761}; KM=0.18 mM for L-ornithine {ECO 0000269|PubMed 3072022, ECO 0000269|PubMed 789338, ECO 0000269|PubMed 8845761}; KM=0.32 mM for L-ornithine {ECO 0000269|PubMed 3072022, ECO 0000269|PubMed 789338, ECO 0000269|PubMed 8845761}; Vmax=0.29 umol/min/ug enzyme {ECO 0000269|PubMed 3072022, ECO 0000269|PubMed 789338, ECO 0000269|PubMed 8845761}; # BRENDA 2.1.3 2026 # BioGrid 4262723 6 # CATALYTIC ACTIVITY OTC1_ECOLI Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. # ENZYME REGULATION OTC1_ECOLI Reversely inhibited by N-(N- Sulfodiaminophosphinyl)-L-ornithine. Zinc is an allosteric regulator of the substrate-bound enzyme and a competitive inhibitor of the free euzyme. {ECO 0000269|PubMed 10747936, ECO 0000269|PubMed 2105398, ECO 0000269|PubMed 2405164, ECO 0000269|PubMed 7048313}. # EcoGene EG10069 argI # FUNCTION OTC1_ECOLI Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline, which is a substrate for argininosuccinate synthetase, the enzyme involved in the final step in arginine biosynthesis. {ECO 0000269|PubMed 3072022, ECO 0000269|PubMed 789338}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0004585 ornithine carbamoyltransferase activity; IDA:EcoCyc. # GO_function GO:0016597 amino acid binding; IEA:InterPro. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0000050 urea cycle; IBA:GO_Central. # GO_process GO:0042450 arginine biosynthetic process via ornithine; IBA:GO_Central. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0071941 nitrogen cycle metabolic process # Gene3D 3.40.50.1370 -; 2. # HAMAP MF_01109 OTCase # IntAct P04391 7 # InterPro IPR002292 Orn/put_carbamltrans # InterPro IPR006130 Asp/Orn_carbamoylTrfase # InterPro IPR006131 Asp_carbamoyltransf_Asp/Orn-bd # InterPro IPR006132 Asp/Orn_carbamoyltranf_P-bd # InterPro IPR024904 OTCase_ArgI # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00330 Arginine and proline metabolism # Organism OTC1_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-arginine biosynthesis; L- arginine from L-ornithine and carbamoyl phosphate step 1/3. # PATRIC 32124079 VBIEscCol129921_4384 # PDB 1AKM X-ray; 2.80 A; A/B/C=2-334 # PDB 1DUV X-ray; 1.70 A; G/H/I=2-334 # PDB 2OTC X-ray; 2.80 A; A/B/C/D/E/F/G/H/I=2-334 # PIR A31314 OWECI # PRINTS PR00100 AOTCASE # PRINTS PR00102 OTCASE # PROSITE PS00097 CARBAMOYLTRANSFERASE # Pfam PF00185 OTCace # Pfam PF02729 OTCace_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName OTC1_ECOLI Ornithine carbamoyltransferase chain I # RefSeq NP_418675 NC_000913.3 # RefSeq WP_000012931 NZ_LN832404.1 # SIMILARITY Belongs to the ATCase/OTCase family. {ECO 0000305}. # SUBCELLULAR LOCATION OTC1_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT OTC1_ECOLI In E.coli strain K12, trimer of identical or non- identical chains are composed of ArgI (I) and/or ArgF (F). The trimer has the following composition FFI, FFF, FII, III. E.coli strains B and W, which are known to contain only ArgI, produce only a trimer of identical chains (III). {ECO 0000269|PubMed 10747936, ECO 0000269|PubMed 4558857, ECO 0000269|PubMed 789338, ECO 0000269|PubMed 9253409, ECO 0000269|PubMed 9275160}. # SUPFAM SSF53671 SSF53671 # TIGRFAMs TIGR00658 orni_carb_tr # UniPathway UPA00068 UER00112 # eggNOG COG0078 LUCA # eggNOG ENOG4105DBV Bacteria BLAST swissprot:OTC1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:OTC1_ECOLI BioCyc ECOL316407:JW4211-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4211-MONOMER BioCyc EcoCyc:CHAINI-MONOMER http://biocyc.org/getid?id=EcoCyc:CHAINI-MONOMER BioCyc MetaCyc:CHAINI-MONOMER http://biocyc.org/getid?id=MetaCyc:CHAINI-MONOMER COG COG0078 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0078 DIP DIP-9143N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9143N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1002/pro.5560050416 http://dx.doi.org/10.1002/pro.5560050416 DOI 10.1016/0022-2836(90)90025-H http://dx.doi.org/10.1016/0022-2836(90)90025-H DOI 10.1016/0022-2836(90)90026-I http://dx.doi.org/10.1016/0022-2836(90)90026-I DOI 10.1021/bi00424a021 http://dx.doi.org/10.1021/bi00424a021 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb0897-622 http://dx.doi.org/10.1038/nsb0897-622 DOI 10.1073/pnas.79.7.2250 http://dx.doi.org/10.1073/pnas.79.7.2250 DOI 10.1073/pnas.94.18.9550 http://dx.doi.org/10.1073/pnas.94.18.9550 DOI 10.1074/jbc.M000585200 http://dx.doi.org/10.1074/jbc.M000585200 DOI 10.1093/nar/11.23.8509 http://dx.doi.org/10.1093/nar/11.23.8509 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1111/j.1432-1033.1972.tb01814.x http://dx.doi.org/10.1111/j.1432-1033.1972.tb01814.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.3.3 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.3.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J02842 http://www.ebi.ac.uk/ena/data/view/J02842 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X00210 http://www.ebi.ac.uk/ena/data/view/X00210 ENZYME 2.1.3.3 http://enzyme.expasy.org/EC/2.1.3.3 EchoBASE EB0067 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0067 EcoGene EG10069 http://www.ecogene.org/geneInfo.php?eg_id=EG10069 EnsemblBacteria AAC77211 http://www.ensemblgenomes.org/id/AAC77211 EnsemblBacteria AAC77211 http://www.ensemblgenomes.org/id/AAC77211 EnsemblBacteria BAE78251 http://www.ensemblgenomes.org/id/BAE78251 EnsemblBacteria BAE78251 http://www.ensemblgenomes.org/id/BAE78251 EnsemblBacteria BAE78251 http://www.ensemblgenomes.org/id/BAE78251 EnsemblBacteria b4254 http://www.ensemblgenomes.org/id/b4254 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004585 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004585 GO_function GO:0016597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016597 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0000050 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000050 GO_process GO:0042450 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042450 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0071941 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071941 Gene3D 3.40.50.1370 http://www.cathdb.info/version/latest/superfamily/3.40.50.1370 GeneID 948774 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948774 HAMAP MF_01109 http://hamap.expasy.org/unirule/MF_01109 HOGENOM HOG000022686 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000022686&db=HOGENOM6 InParanoid P04391 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P04391 IntAct P04391 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P04391* IntEnz 2.1.3.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.3.3 InterPro IPR002292 http://www.ebi.ac.uk/interpro/entry/IPR002292 InterPro IPR006130 http://www.ebi.ac.uk/interpro/entry/IPR006130 InterPro IPR006131 http://www.ebi.ac.uk/interpro/entry/IPR006131 InterPro IPR006132 http://www.ebi.ac.uk/interpro/entry/IPR006132 InterPro IPR024904 http://www.ebi.ac.uk/interpro/entry/IPR024904 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4211 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4211 KEGG_Gene eco:b4254 http://www.genome.jp/dbget-bin/www_bget?eco:b4254 KEGG_Orthology KO:K00611 http://www.genome.jp/dbget-bin/www_bget?KO:K00611 KEGG_Pathway ko00330 http://www.genome.jp/kegg-bin/show_pathway?ko00330 KEGG_Reaction rn:R01398 http://www.genome.jp/dbget-bin/www_bget?rn:R01398 OMA SACWPEA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SACWPEA PDB 1AKM http://www.ebi.ac.uk/pdbe-srv/view/entry/1AKM PDB 1DUV http://www.ebi.ac.uk/pdbe-srv/view/entry/1DUV PDB 2OTC http://www.ebi.ac.uk/pdbe-srv/view/entry/2OTC PDBsum 1AKM http://www.ebi.ac.uk/pdbsum/1AKM PDBsum 1DUV http://www.ebi.ac.uk/pdbsum/1DUV PDBsum 2OTC http://www.ebi.ac.uk/pdbsum/2OTC PRINTS PR00100 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00100 PRINTS PR00102 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00102 PROSITE PS00097 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00097 PSORT swissprot:OTC1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:OTC1_ECOLI PSORT-B swissprot:OTC1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:OTC1_ECOLI PSORT2 swissprot:OTC1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:OTC1_ECOLI Pfam PF00185 http://pfam.xfam.org/family/PF00185 Pfam PF02729 http://pfam.xfam.org/family/PF02729 Phobius swissprot:OTC1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:OTC1_ECOLI PhylomeDB P04391 http://phylomedb.org/?seqid=P04391 ProteinModelPortal P04391 http://www.proteinmodelportal.org/query/uniprot/P04391 PubMed 10747936 http://www.ncbi.nlm.nih.gov/pubmed/10747936 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2105398 http://www.ncbi.nlm.nih.gov/pubmed/2105398 PubMed 2405164 http://www.ncbi.nlm.nih.gov/pubmed/2405164 PubMed 2674127 http://www.ncbi.nlm.nih.gov/pubmed/2674127 PubMed 3072022 http://www.ncbi.nlm.nih.gov/pubmed/3072022 PubMed 4558857 http://www.ncbi.nlm.nih.gov/pubmed/4558857 PubMed 6369246 http://www.ncbi.nlm.nih.gov/pubmed/6369246 PubMed 7048313 http://www.ncbi.nlm.nih.gov/pubmed/7048313 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 789338 http://www.ncbi.nlm.nih.gov/pubmed/789338 PubMed 8845761 http://www.ncbi.nlm.nih.gov/pubmed/8845761 PubMed 9253409 http://www.ncbi.nlm.nih.gov/pubmed/9253409 PubMed 9275160 http://www.ncbi.nlm.nih.gov/pubmed/9275160 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_418675 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418675 RefSeq WP_000012931 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000012931 SMR P04391 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P04391 STRING 511145.b4254 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4254&targetmode=cogs STRING COG0078 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0078&targetmode=cogs SUPFAM SSF53671 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53671 SWISS-2DPAGE P04391 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P04391 TIGRFAMs TIGR00658 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00658 UniProtKB OTC1_ECOLI http://www.uniprot.org/uniprot/OTC1_ECOLI UniProtKB-AC P04391 http://www.uniprot.org/uniprot/P04391 charge swissprot:OTC1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:OTC1_ECOLI eggNOG COG0078 http://eggnogapi.embl.de/nog_data/html/tree/COG0078 eggNOG ENOG4105DBV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DBV epestfind swissprot:OTC1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:OTC1_ECOLI garnier swissprot:OTC1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:OTC1_ECOLI helixturnhelix swissprot:OTC1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:OTC1_ECOLI hmoment swissprot:OTC1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:OTC1_ECOLI iep swissprot:OTC1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:OTC1_ECOLI inforesidue swissprot:OTC1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:OTC1_ECOLI octanol swissprot:OTC1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:OTC1_ECOLI pepcoil swissprot:OTC1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:OTC1_ECOLI pepdigest swissprot:OTC1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:OTC1_ECOLI pepinfo swissprot:OTC1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:OTC1_ECOLI pepnet swissprot:OTC1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:OTC1_ECOLI pepstats swissprot:OTC1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:OTC1_ECOLI pepwheel swissprot:OTC1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:OTC1_ECOLI pepwindow swissprot:OTC1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:OTC1_ECOLI sigcleave swissprot:OTC1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:OTC1_ECOLI ## Database ID URL or Descriptions # AltName MURQ_ECOLI N-acetylmuramic acid 6-phosphate hydrolase # AltName MURQ_ECOLI N-acetylmuramic acid 6-phosphate lyase # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=1.20 mM for N-acetylmuramic acid 6-phosphate {ECO 0000269|PubMed:18837509}; Note=kcat is 5.7 s(-1).; # BioGrid 4260569 7 # CATALYTIC ACTIVITY (R)-lactate + N-acetyl-D-glucosamine 6- phosphate = N-acetylmuramate 6-phosphate + H(2)O. {ECO:0000269|PubMed 15983044}. # CDD cd05007 SIS_Etherase # EcoGene EG14162 murQ # FUNCTION MURQ_ECOLI Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate. Is required for growth on MurNAc as the sole source of carbon and energy. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. {ECO 0000269|PubMed 15983044, ECO 0000269|PubMed 16452451}. # GO_function GO:0016803 ether hydrolase activity; IDA:EcoliWiki. # GO_function GO:0016835 carbon-oxygen lyase activity; IDA:EcoCyc. # GO_function GO:0030246 carbohydrate binding; IEA:UniProtKB-HAMAP. # GO_process GO:0005975 carbohydrate metabolic process; IEA:UniProtKB-HAMAP. # GO_process GO:0009254 peptidoglycan turnover; IMP:EcoCyc. # GO_process GO:0046348 amino sugar catabolic process; IMP:EcoCyc. # GO_process GO:0097173 N-acetylmuramic acid catabolic process; IEA:UniProtKB-UniPathway. # GO_process GO:0097175 1,6-anhydro-N-acetyl-beta-muramic acid catabolic process; IEA:UniProtKB-UniPathway. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # HAMAP MF_00068 MurQ # INDUCTION Induced by MurNAc 6-phosphate that releases the repressor MurR from the DNA. Also up-regulated by the cAMP receptor protein crp via the binding of crp-cAMP to a class I site upstream of the murQ promoter. Repressed by MurR in the absence of MurNAc 6-phosphate. {ECO:0000269|PubMed 18723630}. # IntAct P76535 6 # InterPro IPR001347 SIS # InterPro IPR005486 Glucokinase_regulatory_CS # InterPro IPR005488 Etherase_MurQ # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00520 Amino sugar and nucleotide sugar metabolism # MISCELLANEOUS MURQ_ECOLI A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6- phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product. # Organism MURQ_ECOLI Escherichia coli (strain K12) # PATHWAY MURQ_ECOLI Amino-sugar metabolism; 1,6-anhydro-N-acetylmuramate degradation. # PATHWAY MURQ_ECOLI Amino-sugar metabolism; N-acetylmuramate degradation. # PATHWAY MURQ_ECOLI Cell wall biogenesis; peptidoglycan recycling. # PATRIC 32120241 VBIEscCol129921_2523 # PIR C65017 C65017 # PROSITE PS01272 GCKR # PROSITE PS51464 SIS # Pfam PF01380 SIS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MURQ_ECOLI N-acetylmuramic acid 6-phosphate etherase # RefSeq NP_416923 NC_000913.3 # RefSeq WP_001159160 NZ_LN832404.1 # SIMILARITY Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily. {ECO 0000305}. # SIMILARITY Contains 1 SIS domain. {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 18837509}. # TIGRFAMs TIGR00274 TIGR00274 # eggNOG COG2103 LUCA # eggNOG ENOG4105E15 Bacteria BLAST swissprot:MURQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MURQ_ECOLI BioCyc ECOL316407:JW2421-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2421-MONOMER BioCyc EcoCyc:G7263-MONOMER http://biocyc.org/getid?id=EcoCyc:G7263-MONOMER BioCyc MetaCyc:G7263-MONOMER http://biocyc.org/getid?id=MetaCyc:G7263-MONOMER COG COG2103 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2103 DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1021/bi8014532 http://dx.doi.org/10.1021/bi8014532 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M502208200 http://dx.doi.org/10.1074/jbc.M502208200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00642-08 http://dx.doi.org/10.1128/JB.00642-08 DOI 10.1128/JB.188.4.1660-1662.2006 http://dx.doi.org/10.1128/JB.188.4.1660-1662.2006 EC_number EC:4.2.1.126 http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.126 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 4.2.1.126 http://enzyme.expasy.org/EC/4.2.1.126 EchoBASE EB3914 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3914 EcoGene EG14162 http://www.ecogene.org/geneInfo.php?eg_id=EG14162 EnsemblBacteria AAC75481 http://www.ensemblgenomes.org/id/AAC75481 EnsemblBacteria AAC75481 http://www.ensemblgenomes.org/id/AAC75481 EnsemblBacteria BAA16312 http://www.ensemblgenomes.org/id/BAA16312 EnsemblBacteria BAA16312 http://www.ensemblgenomes.org/id/BAA16312 EnsemblBacteria BAA16312 http://www.ensemblgenomes.org/id/BAA16312 EnsemblBacteria b2428 http://www.ensemblgenomes.org/id/b2428 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016803 GO_function GO:0016835 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016835 GO_function GO:0030246 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030246 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GO_process GO:0009254 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009254 GO_process GO:0046348 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046348 GO_process GO:0097173 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097173 GO_process GO:0097175 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097175 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 946893 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946893 HAMAP MF_00068 http://hamap.expasy.org/unirule/MF_00068 HOGENOM HOG000084045 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000084045&db=HOGENOM6 InParanoid P76535 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76535 IntAct P76535 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76535* IntEnz 4.2.1.126 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.126 InterPro IPR001347 http://www.ebi.ac.uk/interpro/entry/IPR001347 InterPro IPR005486 http://www.ebi.ac.uk/interpro/entry/IPR005486 InterPro IPR005488 http://www.ebi.ac.uk/interpro/entry/IPR005488 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2421 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2421 KEGG_Gene eco:b2428 http://www.genome.jp/dbget-bin/www_bget?eco:b2428 KEGG_Orthology KO:K07106 http://www.genome.jp/dbget-bin/www_bget?KO:K07106 KEGG_Pathway ko00520 http://www.genome.jp/kegg-bin/show_pathway?ko00520 KEGG_Reaction rn:R08555 http://www.genome.jp/dbget-bin/www_bget?rn:R08555 OMA QHQGFIR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QHQGFIR PROSITE PS01272 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01272 PROSITE PS51464 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51464 PSORT swissprot:MURQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MURQ_ECOLI PSORT-B swissprot:MURQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MURQ_ECOLI PSORT2 swissprot:MURQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MURQ_ECOLI Pfam PF01380 http://pfam.xfam.org/family/PF01380 Phobius swissprot:MURQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MURQ_ECOLI PhylomeDB P76535 http://phylomedb.org/?seqid=P76535 ProteinModelPortal P76535 http://www.proteinmodelportal.org/query/uniprot/P76535 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 15983044 http://www.ncbi.nlm.nih.gov/pubmed/15983044 PubMed 16452451 http://www.ncbi.nlm.nih.gov/pubmed/16452451 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723630 http://www.ncbi.nlm.nih.gov/pubmed/18723630 PubMed 18837509 http://www.ncbi.nlm.nih.gov/pubmed/18837509 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416923 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416923 RefSeq WP_001159160 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001159160 SMR P76535 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76535 STRING 511145.b2428 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2428&targetmode=cogs STRING COG2103 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2103&targetmode=cogs TIGRFAMs TIGR00274 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00274 UniProtKB MURQ_ECOLI http://www.uniprot.org/uniprot/MURQ_ECOLI UniProtKB-AC P76535 http://www.uniprot.org/uniprot/P76535 charge swissprot:MURQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MURQ_ECOLI eggNOG COG2103 http://eggnogapi.embl.de/nog_data/html/tree/COG2103 eggNOG ENOG4105E15 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E15 epestfind swissprot:MURQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MURQ_ECOLI garnier swissprot:MURQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MURQ_ECOLI helixturnhelix swissprot:MURQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MURQ_ECOLI hmoment swissprot:MURQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MURQ_ECOLI iep swissprot:MURQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MURQ_ECOLI inforesidue swissprot:MURQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MURQ_ECOLI octanol swissprot:MURQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MURQ_ECOLI pepcoil swissprot:MURQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MURQ_ECOLI pepdigest swissprot:MURQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MURQ_ECOLI pepinfo swissprot:MURQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MURQ_ECOLI pepnet swissprot:MURQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MURQ_ECOLI pepstats swissprot:MURQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MURQ_ECOLI pepwheel swissprot:MURQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MURQ_ECOLI pepwindow swissprot:MURQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MURQ_ECOLI sigcleave swissprot:MURQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MURQ_ECOLI ## Database ID URL or Descriptions # AltName SLMA_ECOLI Protein Ttk # AltName SLMA_ECOLI Synthetically lethal with a defective Min system protein A # BioGrid 4259414 339 # EcoGene EG11191 slmA # FUNCTION SLMA_ECOLI Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. {ECO 0000255|HAMAP-Rule MF_01839, ECO 0000269|PubMed 15916962, ECO 0000269|PubMed 21113127, ECO 0000269|PubMed 21321206}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_component GO:0043590 bacterial nucleoid; IDA:EcoCyc. # GO_function GO:0000976 transcription regulatory region sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0003677 DNA binding; IDA:EcoliWiki. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0043565 sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0000918 barrier septum site selection; IMP:EcoliWiki. # GO_process GO:0006355 regulation of transcription, DNA-templated; IBA:GO_Central. # GO_process GO:0010974 negative regulation of barrier septum assembly; IDA:EcoliWiki. # GO_process GO:0032272 negative regulation of protein polymerization; IDA:EcoCyc. # GO_process GO:0043547 positive regulation of GTPase activity; IDA:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_component GO:0043226 organelle # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # Gene3D 1.10.357.10 -; 1. # HAMAP MF_01839 NO_factor_SlmA # INTERACTION SLMA_ECOLI Self; NbExp=2; IntAct=EBI-8520580, EBI-8520580; # InterPro IPR001647 HTH_TetR # InterPro IPR009057 Homeodomain-like # InterPro IPR011075 Tet_transcr_reg_TetR-rel_C # InterPro IPR015893 Tet_transcr_reg_TetR-like_C # InterPro IPR023769 NO_SlmA # InterPro IPR023772 DNA-bd_HTH_TetR-type_CS # KEGG_Brite ko03000 Transcription factors # KEGG_Brite ko03036 Chromosome # MISCELLANEOUS SLMA_ECOLI Inhibitory activity is enhanced by sequence- specific DNA binding. # Organism SLMA_ECOLI Escherichia coli (strain K12) # PATRIC 32122769 VBIEscCol129921_3761 # PDB 3NXC X-ray; 2.50 A; A=1-198 # PDB 5HBU X-ray; 2.60 A; A/B/C/D/E/F/G/H=7-198 # PDB 5K58 X-ray; 2.77 A; A/B/E/F=9-198 # PROSITE PS01081 HTH_TETR_1 # PROSITE PS50977 HTH_TETR_2 # Pfam PF00440 TetR_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Nucleoid occlusion factor SlmA {ECO:0000255|HAMAP-Rule MF_01839} # RefSeq NP_418098 NC_000913.3 # RefSeq WP_000818601 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA61994.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the nucleoid occlusion factor SlmA family. {ECO:0000255|HAMAP-Rule MF_01839}. # SIMILARITY Contains 1 HTH tetR-type DNA-binding domain. {ECO:0000255|HAMAP-Rule MF_01839}. # SUBCELLULAR LOCATION SLMA_ECOLI Cytoplasm, nucleoid {ECO 0000255|HAMAP- Rule MF_01839, ECO 0000269|PubMed 15916962}. # SUBUNIT SLMA_ECOLI Homodimer. Interacts with FtsZ. {ECO 0000255|HAMAP- Rule MF_01839, ECO 0000269|PubMed 15916962, ECO 0000269|PubMed 21113127, ECO 0000269|PubMed 21321206}. # SUPFAM SSF46689 SSF46689 # SUPFAM SSF48498 SSF48498 # eggNOG ENOG4108ENE Bacteria # eggNOG ENOG410XQXX LUCA BLAST swissprot:SLMA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SLMA_ECOLI BioCyc ECOL316407:JW5641-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5641-MONOMER BioCyc EcoCyc:EG11191-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11191-MONOMER COG COG1309 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1309 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1016/j.molcel.2005.04.012 http://dx.doi.org/10.1016/j.molcel.2005.04.012 DOI 10.1038/emboj.2010.288 http://dx.doi.org/10.1038/emboj.2010.288 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.1018674108 http://dx.doi.org/10.1073/pnas.1018674108 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V01498 http://www.ebi.ac.uk/ena/data/view/V01498 EMBL V01578 http://www.ebi.ac.uk/ena/data/view/V01578 EMBL X01714 http://www.ebi.ac.uk/ena/data/view/X01714 EchoBASE EB1177 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1177 EcoGene EG11191 http://www.ecogene.org/geneInfo.php?eg_id=EG11191 EnsemblBacteria AAC76665 http://www.ensemblgenomes.org/id/AAC76665 EnsemblBacteria AAC76665 http://www.ensemblgenomes.org/id/AAC76665 EnsemblBacteria BAE77651 http://www.ensemblgenomes.org/id/BAE77651 EnsemblBacteria BAE77651 http://www.ensemblgenomes.org/id/BAE77651 EnsemblBacteria BAE77651 http://www.ensemblgenomes.org/id/BAE77651 EnsemblBacteria b3641 http://www.ensemblgenomes.org/id/b3641 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0043590 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043590 GO_function GO:0000976 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000976 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0000918 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000918 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0010974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010974 GO_process GO:0032272 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032272 GO_process GO:0043547 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043547 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0043226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.10.357.10 http://www.cathdb.info/version/latest/superfamily/1.10.357.10 GeneID 948158 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948158 HAMAP MF_01839 http://hamap.expasy.org/unirule/MF_01839 HOGENOM HOG000266053 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000266053&db=HOGENOM6 InParanoid P0C093 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0C093 IntAct P0C093 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0C093* InterPro IPR001647 http://www.ebi.ac.uk/interpro/entry/IPR001647 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR011075 http://www.ebi.ac.uk/interpro/entry/IPR011075 InterPro IPR015893 http://www.ebi.ac.uk/interpro/entry/IPR015893 InterPro IPR023769 http://www.ebi.ac.uk/interpro/entry/IPR023769 InterPro IPR023772 http://www.ebi.ac.uk/interpro/entry/IPR023772 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene ecj:JW5641 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5641 KEGG_Gene eco:b3641 http://www.genome.jp/dbget-bin/www_bget?eco:b3641 KEGG_Orthology KO:K05501 http://www.genome.jp/dbget-bin/www_bget?KO:K05501 MINT MINT-8092383 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8092383 OMA RNPGITR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RNPGITR PDB 3NXC http://www.ebi.ac.uk/pdbe-srv/view/entry/3NXC PDB 5HBU http://www.ebi.ac.uk/pdbe-srv/view/entry/5HBU PDB 5K58 http://www.ebi.ac.uk/pdbe-srv/view/entry/5K58 PDBsum 3NXC http://www.ebi.ac.uk/pdbsum/3NXC PDBsum 5HBU http://www.ebi.ac.uk/pdbsum/5HBU PDBsum 5K58 http://www.ebi.ac.uk/pdbsum/5K58 PROSITE PS01081 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01081 PROSITE PS50977 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50977 PSORT swissprot:SLMA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SLMA_ECOLI PSORT-B swissprot:SLMA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SLMA_ECOLI PSORT2 swissprot:SLMA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SLMA_ECOLI Pfam PF00440 http://pfam.xfam.org/family/PF00440 Phobius swissprot:SLMA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SLMA_ECOLI PhylomeDB P0C093 http://phylomedb.org/?seqid=P0C093 ProteinModelPortal P0C093 http://www.proteinmodelportal.org/query/uniprot/P0C093 PubMed 15916962 http://www.ncbi.nlm.nih.gov/pubmed/15916962 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21113127 http://www.ncbi.nlm.nih.gov/pubmed/21113127 PubMed 21321206 http://www.ncbi.nlm.nih.gov/pubmed/21321206 PubMed 2830228 http://www.ncbi.nlm.nih.gov/pubmed/2830228 PubMed 6139280 http://www.ncbi.nlm.nih.gov/pubmed/6139280 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418098 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418098 RefSeq WP_000818601 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000818601 SMR P0C093 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0C093 STRING 511145.b3641 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3641&targetmode=cogs STRING COG1309 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1309&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF48498 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48498 UniProtKB SLMA_ECOLI http://www.uniprot.org/uniprot/SLMA_ECOLI UniProtKB-AC P0C093 http://www.uniprot.org/uniprot/P0C093 charge swissprot:SLMA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SLMA_ECOLI eggNOG ENOG4108ENE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ENE eggNOG ENOG410XQXX http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQXX epestfind swissprot:SLMA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SLMA_ECOLI garnier swissprot:SLMA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SLMA_ECOLI helixturnhelix swissprot:SLMA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SLMA_ECOLI hmoment swissprot:SLMA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SLMA_ECOLI iep swissprot:SLMA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SLMA_ECOLI inforesidue swissprot:SLMA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SLMA_ECOLI octanol swissprot:SLMA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SLMA_ECOLI pepcoil swissprot:SLMA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SLMA_ECOLI pepdigest swissprot:SLMA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SLMA_ECOLI pepinfo swissprot:SLMA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SLMA_ECOLI pepnet swissprot:SLMA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SLMA_ECOLI pepstats swissprot:SLMA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SLMA_ECOLI pepwheel swissprot:SLMA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SLMA_ECOLI pepwindow swissprot:SLMA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SLMA_ECOLI sigcleave swissprot:SLMA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SLMA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261919 151 # DISRUPTION PHENOTYPE Disruption increases sensitivity of cells to microcin J25. {ECO:0000269|PubMed 15866933}. # EcoGene EG12070 yojI # FUNCTION YOJI_ECOLI Mediates resistance to the antibacterial peptide microcin J25, when expressed from a multicopy vector. Functions as an efflux pump for microcin J25, with the help of the outer membrane channel TolC. {ECO 0000269|PubMed 15866933}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0015197 peptide transporter activity; IMP:EcoCyc. # GO_function GO:0042626 ATPase activity, coupled to transmembrane movement of substances; IEA:InterPro. # GO_process GO:0042884 microcin transport; IMP:EcoliWiki. # GO_process GO:0046677 response to antibiotic; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.300 -; 1. # IntAct P33941 5 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR005898 Cyc_pep_transpt # InterPro IPR011527 ABC1_TM_dom # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism YOJI_ECOLI Escherichia coli (strain K12) # PATRIC 32119781 VBIEscCol129921_2300 # PIR A64991 A64991 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # PROSITE PS50929 ABC_TM1F # Pfam PF00005 ABC_tran # Pfam PF00664 ABC_membrane # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ABC transporter ATP-binding/permease protein YojI {ECO 0000305} # RefSeq NP_416715 NC_000913.3 # RefSeq WP_000422182 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA # SUBCELLULAR LOCATION YOJI_ECOLI Cell inner membrane {ECO 0000305}; Multi- pass membrane protein {ECO 0000255}. # SUPFAM SSF52540 SSF52540 # SUPFAM SSF90123 SSF90123 # TCDB 3.A.1.113 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR01194 cyc_pep_trnsptr # eggNOG COG4615 LUCA # eggNOG ENOG4105IBP Bacteria BLAST swissprot:YOJI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YOJI_ECOLI BioCyc ECOL316407:JW2199-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2199-MONOMER BioCyc EcoCyc:YOJI-MONOMER http://biocyc.org/getid?id=EcoCyc:YOJI-MONOMER COG COG4615 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4615 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.187.10.3465-3470.2005 http://dx.doi.org/10.1128/JB.187.10.3465-3470.2005 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00008 http://www.ebi.ac.uk/ena/data/view/U00008 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1997 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1997 EcoGene EG12070 http://www.ecogene.org/geneInfo.php?eg_id=EG12070 EnsemblBacteria AAC75271 http://www.ensemblgenomes.org/id/AAC75271 EnsemblBacteria AAC75271 http://www.ensemblgenomes.org/id/AAC75271 EnsemblBacteria BAA15994 http://www.ensemblgenomes.org/id/BAA15994 EnsemblBacteria BAA15994 http://www.ensemblgenomes.org/id/BAA15994 EnsemblBacteria BAA15994 http://www.ensemblgenomes.org/id/BAA15994 EnsemblBacteria b2211 http://www.ensemblgenomes.org/id/b2211 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0015197 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015197 GO_function GO:0042626 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042626 GO_process GO:0042884 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042884 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 946705 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946705 HOGENOM HOG000260219 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260219&db=HOGENOM6 InParanoid P33941 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33941 IntAct P33941 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33941* InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR005898 http://www.ebi.ac.uk/interpro/entry/IPR005898 InterPro IPR011527 http://www.ebi.ac.uk/interpro/entry/IPR011527 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2199 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2199 KEGG_Gene eco:b2211 http://www.genome.jp/dbget-bin/www_bget?eco:b2211 KEGG_Orthology KO:K06159 http://www.genome.jp/dbget-bin/www_bget?KO:K06159 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA IAFINLR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IAFINLR PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PROSITE PS50929 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50929 PSORT swissprot:YOJI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YOJI_ECOLI PSORT-B swissprot:YOJI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YOJI_ECOLI PSORT2 swissprot:YOJI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YOJI_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Pfam PF00664 http://pfam.xfam.org/family/PF00664 Phobius swissprot:YOJI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YOJI_ECOLI PhylomeDB P33941 http://phylomedb.org/?seqid=P33941 ProteinModelPortal P33941 http://www.proteinmodelportal.org/query/uniprot/P33941 PubMed 15866933 http://www.ncbi.nlm.nih.gov/pubmed/15866933 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416715 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416715 RefSeq WP_000422182 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000422182 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 STRING 511145.b2211 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2211&targetmode=cogs STRING COG4615 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4615&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SUPFAM SSF90123 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90123 TCDB 3.A.1.113 http://www.tcdb.org/search/result.php?tc=3.A.1.113 TIGRFAMs TIGR01194 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01194 UniProtKB YOJI_ECOLI http://www.uniprot.org/uniprot/YOJI_ECOLI UniProtKB-AC P33941 http://www.uniprot.org/uniprot/P33941 charge swissprot:YOJI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YOJI_ECOLI eggNOG COG4615 http://eggnogapi.embl.de/nog_data/html/tree/COG4615 eggNOG ENOG4105IBP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105IBP epestfind swissprot:YOJI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YOJI_ECOLI garnier swissprot:YOJI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YOJI_ECOLI helixturnhelix swissprot:YOJI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YOJI_ECOLI hmoment swissprot:YOJI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YOJI_ECOLI iep swissprot:YOJI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YOJI_ECOLI inforesidue swissprot:YOJI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YOJI_ECOLI octanol swissprot:YOJI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YOJI_ECOLI pepcoil swissprot:YOJI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YOJI_ECOLI pepdigest swissprot:YOJI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YOJI_ECOLI pepinfo swissprot:YOJI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YOJI_ECOLI pepnet swissprot:YOJI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YOJI_ECOLI pepstats swissprot:YOJI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YOJI_ECOLI pepwheel swissprot:YOJI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YOJI_ECOLI pepwindow swissprot:YOJI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YOJI_ECOLI sigcleave swissprot:YOJI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YOJI_ECOLI ## Database ID URL or Descriptions # BioGrid 4261062 85 # EcoGene EG10227 dicB # FUNCTION DICB_ECOLI Involved in cell division inhibition; this function can be repressed by DicA and DicC proteins as well as antitoxin CbeA (yeeU). {ECO 0000269|PubMed 22515815}. # GO_process GO:0007049 cell cycle; IEA:UniProtKB-KW. # GO_process GO:0051301 cell division; IEA:UniProtKB-KW. # GO_process GO:0051302 regulation of cell division; IMP:EcoliWiki. # GOslim_process GO:0007049 cell cycle # GOslim_process GO:0008150 biological_process # GOslim_process GO:0051301 cell division # IntAct P09557 6 # InterPro IPR008022 DicB # Organism DICB_ECOLI Escherichia coli (strain K12) # PATRIC 32118452 VBIEscCol129921_1646 # PIR A64913 CEECDB # Pfam PF05358 DicB # ProDom PD053043 DicB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DICB_ECOLI Division inhibition protein DicB # RefSeq NP_416092 NC_000913.3 # RefSeq WP_000854559 NZ_LN832404.1 BLAST swissprot:DICB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DICB_ECOLI BioCyc ECOL316407:JW1566-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1566-MONOMER BioCyc EcoCyc:EG10227-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10227-MONOMER DIP DIP-9440N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9440N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/16.14.6327 http://dx.doi.org/10.1093/nar/16.14.6327 DOI 10.1111/j.1365-2958.2012.08068.x http://dx.doi.org/10.1111/j.1365-2958.2012.08068.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X07465 http://www.ebi.ac.uk/ena/data/view/X07465 EchoBASE EB0223 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0223 EcoGene EG10227 http://www.ecogene.org/geneInfo.php?eg_id=EG10227 EnsemblBacteria AAC74647 http://www.ensemblgenomes.org/id/AAC74647 EnsemblBacteria AAC74647 http://www.ensemblgenomes.org/id/AAC74647 EnsemblBacteria BAA15279 http://www.ensemblgenomes.org/id/BAA15279 EnsemblBacteria BAA15279 http://www.ensemblgenomes.org/id/BAA15279 EnsemblBacteria BAA15279 http://www.ensemblgenomes.org/id/BAA15279 EnsemblBacteria b1575 http://www.ensemblgenomes.org/id/b1575 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GO_process GO:0051302 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051302 GOslim_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GeneID 946110 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946110 HOGENOM HOG000050182 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000050182&db=HOGENOM6 IntAct P09557 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P09557* InterPro IPR008022 http://www.ebi.ac.uk/interpro/entry/IPR008022 KEGG_Gene ecj:JW1566 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1566 KEGG_Gene eco:b1575 http://www.genome.jp/dbget-bin/www_bget?eco:b1575 OMA LNQICIV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LNQICIV PSORT swissprot:DICB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DICB_ECOLI PSORT-B swissprot:DICB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DICB_ECOLI PSORT2 swissprot:DICB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DICB_ECOLI Pfam PF05358 http://pfam.xfam.org/family/PF05358 Phobius swissprot:DICB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DICB_ECOLI ProteinModelPortal P09557 http://www.proteinmodelportal.org/query/uniprot/P09557 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22515815 http://www.ncbi.nlm.nih.gov/pubmed/22515815 PubMed 3041373 http://www.ncbi.nlm.nih.gov/pubmed/3041373 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416092 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416092 RefSeq WP_000854559 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000854559 STRING 511145.b1575 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1575&targetmode=cogs UniProtKB DICB_ECOLI http://www.uniprot.org/uniprot/DICB_ECOLI UniProtKB-AC P09557 http://www.uniprot.org/uniprot/P09557 charge swissprot:DICB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DICB_ECOLI epestfind swissprot:DICB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DICB_ECOLI garnier swissprot:DICB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DICB_ECOLI helixturnhelix swissprot:DICB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DICB_ECOLI hmoment swissprot:DICB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DICB_ECOLI iep swissprot:DICB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DICB_ECOLI inforesidue swissprot:DICB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DICB_ECOLI octanol swissprot:DICB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DICB_ECOLI pepcoil swissprot:DICB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DICB_ECOLI pepdigest swissprot:DICB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DICB_ECOLI pepinfo swissprot:DICB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DICB_ECOLI pepnet swissprot:DICB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DICB_ECOLI pepstats swissprot:DICB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DICB_ECOLI pepwheel swissprot:DICB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DICB_ECOLI pepwindow swissprot:DICB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DICB_ECOLI sigcleave swissprot:DICB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DICB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260008 15 # EcoGene EG12702 ycaK # GO_function GO:0010181 FMN binding; IDA:EcoCyc. # GO_function GO:0016491 oxidoreductase activity; IEA:UniProtKB-KW. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.360 -; 1. # IntAct P43340 4 # InterPro IPR003680 Flavodoxin_fold # InterPro IPR029039 Flavoprotein-like_dom # KEGG_Brite ko01000 Enzymes # Organism YCAK_ECOLI Escherichia coli (strain K12) # PATRIC 32117015 VBIEscCol129921_0932 # PIR D64829 D64829 # Pfam PF02525 Flavodoxin_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCAK_ECOLI Uncharacterized NAD(P)H oxidoreductase YcaK # RefSeq NP_415421 NC_000913.3 # RefSeq WP_001190363 NZ_LN832404.1 # SIMILARITY Belongs to the NAD(P)H dehydrogenase (quinone) family. {ECO 0000305}. # SUPFAM SSF52218 SSF52218 # eggNOG COG2249 LUCA # eggNOG ENOG4108X0B Bacteria BLAST swissprot:YCAK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCAK_ECOLI BioCyc ECOL316407:JW0884-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0884-MONOMER BioCyc EcoCyc:EG12702-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12702-MONOMER COG COG2249 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2249 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1111/j.1432-1033.1988.tb14356.x http://dx.doi.org/10.1111/j.1432-1033.1988.tb14356.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.6.99.- http://www.genome.jp/dbget-bin/www_bget?EC:1.6.99.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X08035 http://www.ebi.ac.uk/ena/data/view/X08035 ENZYME 1.6.99.- http://enzyme.expasy.org/EC/1.6.99.- EchoBASE EB2564 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2564 EcoGene EG12702 http://www.ecogene.org/geneInfo.php?eg_id=EG12702 EnsemblBacteria AAC73987 http://www.ensemblgenomes.org/id/AAC73987 EnsemblBacteria AAC73987 http://www.ensemblgenomes.org/id/AAC73987 EnsemblBacteria BAA35636 http://www.ensemblgenomes.org/id/BAA35636 EnsemblBacteria BAA35636 http://www.ensemblgenomes.org/id/BAA35636 EnsemblBacteria BAA35636 http://www.ensemblgenomes.org/id/BAA35636 EnsemblBacteria b0901 http://www.ensemblgenomes.org/id/b0901 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0010181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010181 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.360 http://www.cathdb.info/version/latest/superfamily/3.40.50.360 GeneID 945520 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945520 HOGENOM HOG000149971 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000149971&db=HOGENOM6 InParanoid P43340 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P43340 IntAct P43340 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P43340* IntEnz 1.6.99 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.6.99 InterPro IPR003680 http://www.ebi.ac.uk/interpro/entry/IPR003680 InterPro IPR029039 http://www.ebi.ac.uk/interpro/entry/IPR029039 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0884 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0884 KEGG_Gene eco:b0901 http://www.genome.jp/dbget-bin/www_bget?eco:b0901 KEGG_Orthology KO:K00358 http://www.genome.jp/dbget-bin/www_bget?KO:K00358 OMA YCGITDI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YCGITDI PSORT swissprot:YCAK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCAK_ECOLI PSORT-B swissprot:YCAK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCAK_ECOLI PSORT2 swissprot:YCAK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCAK_ECOLI Pfam PF02525 http://pfam.xfam.org/family/PF02525 Phobius swissprot:YCAK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCAK_ECOLI PhylomeDB P43340 http://phylomedb.org/?seqid=P43340 ProteinModelPortal P43340 http://www.proteinmodelportal.org/query/uniprot/P43340 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3053170 http://www.ncbi.nlm.nih.gov/pubmed/3053170 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415421 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415421 RefSeq WP_001190363 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001190363 SMR P43340 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P43340 STRING 511145.b0901 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0901&targetmode=cogs STRING COG2249 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2249&targetmode=cogs SUPFAM SSF52218 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52218 UniProtKB YCAK_ECOLI http://www.uniprot.org/uniprot/YCAK_ECOLI UniProtKB-AC P43340 http://www.uniprot.org/uniprot/P43340 charge swissprot:YCAK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCAK_ECOLI eggNOG COG2249 http://eggnogapi.embl.de/nog_data/html/tree/COG2249 eggNOG ENOG4108X0B http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108X0B epestfind swissprot:YCAK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCAK_ECOLI garnier swissprot:YCAK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCAK_ECOLI helixturnhelix swissprot:YCAK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCAK_ECOLI hmoment swissprot:YCAK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCAK_ECOLI iep swissprot:YCAK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCAK_ECOLI inforesidue swissprot:YCAK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCAK_ECOLI octanol swissprot:YCAK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCAK_ECOLI pepcoil swissprot:YCAK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCAK_ECOLI pepdigest swissprot:YCAK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCAK_ECOLI pepinfo swissprot:YCAK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCAK_ECOLI pepnet swissprot:YCAK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCAK_ECOLI pepstats swissprot:YCAK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCAK_ECOLI pepwheel swissprot:YCAK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCAK_ECOLI pepwindow swissprot:YCAK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCAK_ECOLI sigcleave swissprot:YCAK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCAK_ECOLI ## Database ID URL or Descriptions # BioGrid 4261798 146 # EcoGene EG12027 yeiH # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR004630 UPF0324_bac # InterPro IPR018383 UPF0324_pro # Organism YEIH_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30106 PTHR30106 # PATRIC 32119665 VBIEscCol129921_2243 # PIR E64984 E64984 # Pfam PF03601 Cons_hypoth698 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEIH_ECOLI UPF0324 inner membrane protein YeiH # RefSeq NP_416663 NC_000913.3 # RefSeq WP_000182053 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0324 family. {ECO 0000305}. # SUBCELLULAR LOCATION YEIH_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.98.1 the putative sulfate exporter (pse) family # TIGRFAMs TIGR00698 TIGR00698 # eggNOG COG2855 LUCA # eggNOG ENOG4105HMI Bacteria BLAST swissprot:YEIH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEIH_ECOLI BioCyc ECOL316407:JW2145-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2145-MONOMER BioCyc EcoCyc:EG12027-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12027-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1962 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1962 EcoGene EG12027 http://www.ecogene.org/geneInfo.php?eg_id=EG12027 EnsemblBacteria AAC75219 http://www.ensemblgenomes.org/id/AAC75219 EnsemblBacteria AAC75219 http://www.ensemblgenomes.org/id/AAC75219 EnsemblBacteria BAE76635 http://www.ensemblgenomes.org/id/BAE76635 EnsemblBacteria BAE76635 http://www.ensemblgenomes.org/id/BAE76635 EnsemblBacteria BAE76635 http://www.ensemblgenomes.org/id/BAE76635 EnsemblBacteria b2158 http://www.ensemblgenomes.org/id/b2158 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 946668 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946668 HOGENOM HOG000056253 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000056253&db=HOGENOM6 InParanoid P62723 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P62723 InterPro IPR004630 http://www.ebi.ac.uk/interpro/entry/IPR004630 InterPro IPR018383 http://www.ebi.ac.uk/interpro/entry/IPR018383 KEGG_Gene ecj:JW2145 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2145 KEGG_Gene eco:b2158 http://www.genome.jp/dbget-bin/www_bget?eco:b2158 OMA FTIFVVY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FTIFVVY PANTHER PTHR30106 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30106 PSORT swissprot:YEIH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEIH_ECOLI PSORT-B swissprot:YEIH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEIH_ECOLI PSORT2 swissprot:YEIH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEIH_ECOLI Pfam PF03601 http://pfam.xfam.org/family/PF03601 Phobius swissprot:YEIH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEIH_ECOLI PhylomeDB P62723 http://phylomedb.org/?seqid=P62723 ProteinModelPortal P62723 http://www.proteinmodelportal.org/query/uniprot/P62723 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416663 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416663 RefSeq WP_000182053 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000182053 STRING 511145.b2158 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2158&targetmode=cogs TCDB 2.A.98.1 http://www.tcdb.org/search/result.php?tc=2.A.98.1 TIGRFAMs TIGR00698 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00698 UniProtKB YEIH_ECOLI http://www.uniprot.org/uniprot/YEIH_ECOLI UniProtKB-AC P62723 http://www.uniprot.org/uniprot/P62723 charge swissprot:YEIH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEIH_ECOLI eggNOG COG2855 http://eggnogapi.embl.de/nog_data/html/tree/COG2855 eggNOG ENOG4105HMI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105HMI epestfind swissprot:YEIH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEIH_ECOLI garnier swissprot:YEIH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEIH_ECOLI helixturnhelix swissprot:YEIH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEIH_ECOLI hmoment swissprot:YEIH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEIH_ECOLI iep swissprot:YEIH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEIH_ECOLI inforesidue swissprot:YEIH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEIH_ECOLI octanol swissprot:YEIH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEIH_ECOLI pepcoil swissprot:YEIH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEIH_ECOLI pepdigest swissprot:YEIH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEIH_ECOLI pepinfo swissprot:YEIH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEIH_ECOLI pepnet swissprot:YEIH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEIH_ECOLI pepstats swissprot:YEIH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEIH_ECOLI pepwheel swissprot:YEIH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEIH_ECOLI pepwindow swissprot:YEIH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEIH_ECOLI sigcleave swissprot:YEIH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEIH_ECOLI ## Database ID URL or Descriptions # AltName D-tyrosyl-tRNA(Tyr) deacylase {ECO:0000303|PubMed 10383414} # BRENDA 3.1.1.96 2026 # BioGrid 4262640 2 # CATALYTIC ACTIVITY DTD_ECOLI A D-aminoacyl-tRNA + H(2)O = a D-amino acid + tRNA. {ECO 0000255|HAMAP-Rule MF_00518, ECO 0000269|PubMed 10918062}. # CDD cd00563 Dtyr_deacylase # EcoGene EG11852 dtd # FUNCTION DTD_ECOLI D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo. Catalyzes the hydrolysis of D-tyrosyl-tRNA(Tyr), D-aspartyl- tRNA(Asp) and D-tryptophanyl-tRNA(Trp). {ECO 0000269|PubMed 10918062}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0002161 aminoacyl-tRNA editing activity; IDA:EcoCyc. # GO_function GO:0051500 D-tyrosyl-tRNA(Tyr) deacylase activity; IDA:EcoCyc. # GO_process GO:0006399 tRNA metabolic process; IMP:EcoCyc. # GO_process GO:0009408 response to heat; IMP:EcoCyc. # GO_process GO:0019478 D-amino acid catabolic process; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009056 catabolic process # Gene3D 3.50.80.10 -; 1. # HAMAP MF_00518 Deacylase_Dtd # IntAct P0A6M4 9 # InterPro IPR003732 Daa-tRNA_deacyls_DTD # InterPro IPR023509 DTD-like_dom # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # Organism DTD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10472 PTHR10472 # PATRIC 32123277 VBIEscCol129921_3999 # PDB 1JKE X-ray; 1.55 A; A/B/C/D=1-145 # PIR S40831 S40831 # Pfam PF02580 Tyr_Deacylase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DTD_ECOLI D-aminoacyl-tRNA deacylase {ECO 0000255|HAMAP-Rule MF_00518, ECO 0000303|PubMed 10918062} # RefSeq NP_418323 NC_000913.3 # RefSeq WP_000560983 NZ_LN832404.1 # SIMILARITY Belongs to the DTD family. {ECO:0000255|HAMAP- Rule MF_00518, ECO:0000305}. # SUBCELLULAR LOCATION DTD_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00518, ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 11568181}. # SUPFAM SSF69500 SSF69500 # TIGRFAMs TIGR00256 TIGR00256 # eggNOG COG1490 LUCA # eggNOG ENOG4108YYA Bacteria BLAST swissprot:DTD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DTD_ECOLI BioCyc ECOL316407:JW3858-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3858-MONOMER BioCyc EcoCyc:EG11852-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11852-MONOMER BioCyc MetaCyc:EG11852-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11852-MONOMER COG COG1490 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1490 DIP DIP-47962N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47962N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.274.27.19109 http://dx.doi.org/10.1074/jbc.274.27.19109 DOI 10.1074/jbc.M005166200 http://dx.doi.org/10.1074/jbc.M005166200 DOI 10.1074/jbc.M106550200 http://dx.doi.org/10.1074/jbc.M106550200 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.1.96 {ECO:0000255|HAMAP-Rule:MF_00518, ECO:0000269|PubMed:10918062} http://www.genome.jp/dbget-bin/www_bget?EC:3.1.1.96 {ECO:0000255|HAMAP-Rule:MF_00518, ECO:0000269|PubMed:10918062} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.1.96 {ECO:0000255|HAMAP-Rule:MF_00518, ECO:0000269|PubMed:10918062} http://enzyme.expasy.org/EC/3.1.1.96 {ECO:0000255|HAMAP-Rule:MF_00518, ECO:0000269|PubMed:10918062} EchoBASE EB1798 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1798 EcoGene EG11852 http://www.ecogene.org/geneInfo.php?eg_id=EG11852 EnsemblBacteria AAD13449 http://www.ensemblgenomes.org/id/AAD13449 EnsemblBacteria AAD13449 http://www.ensemblgenomes.org/id/AAD13449 EnsemblBacteria BAE77422 http://www.ensemblgenomes.org/id/BAE77422 EnsemblBacteria BAE77422 http://www.ensemblgenomes.org/id/BAE77422 EnsemblBacteria BAE77422 http://www.ensemblgenomes.org/id/BAE77422 EnsemblBacteria b3887 http://www.ensemblgenomes.org/id/b3887 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0002161 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002161 GO_function GO:0051500 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051500 GO_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GO_process GO:0019478 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019478 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 3.50.80.10 http://www.cathdb.info/version/latest/superfamily/3.50.80.10 GeneID 948378 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948378 HAMAP MF_00518 http://hamap.expasy.org/unirule/MF_00518 HOGENOM HOG000113982 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000113982&db=HOGENOM6 InParanoid P0A6M4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6M4 IntAct P0A6M4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6M4* IntEnz 3.1.1.96 {ECO:0000255|HAMAP-Rule:MF_00518, ECO:0000269|PubMed:10918062} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.1.96 {ECO:0000255|HAMAP-Rule:MF_00518, ECO:0000269|PubMed:10918062} InterPro IPR003732 http://www.ebi.ac.uk/interpro/entry/IPR003732 InterPro IPR023509 http://www.ebi.ac.uk/interpro/entry/IPR023509 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW3858 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3858 KEGG_Gene eco:b3887 http://www.genome.jp/dbget-bin/www_bget?eco:b3887 KEGG_Orthology KO:K07560 http://www.genome.jp/dbget-bin/www_bget?KO:K07560 OMA DGPVTIW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DGPVTIW PANTHER PTHR10472 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10472 PDB 1JKE http://www.ebi.ac.uk/pdbe-srv/view/entry/1JKE PDBsum 1JKE http://www.ebi.ac.uk/pdbsum/1JKE PSORT swissprot:DTD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DTD_ECOLI PSORT-B swissprot:DTD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DTD_ECOLI PSORT2 swissprot:DTD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DTD_ECOLI Pfam PF02580 http://pfam.xfam.org/family/PF02580 Phobius swissprot:DTD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DTD_ECOLI PhylomeDB P0A6M4 http://phylomedb.org/?seqid=P0A6M4 ProteinModelPortal P0A6M4 http://www.proteinmodelportal.org/query/uniprot/P0A6M4 PubMed 10383414 http://www.ncbi.nlm.nih.gov/pubmed/10383414 PubMed 10918062 http://www.ncbi.nlm.nih.gov/pubmed/10918062 PubMed 11568181 http://www.ncbi.nlm.nih.gov/pubmed/11568181 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418323 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418323 RefSeq WP_000560983 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000560983 SMR P0A6M4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6M4 STRING 511145.b3887 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3887&targetmode=cogs STRING COG1490 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1490&targetmode=cogs SUPFAM SSF69500 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF69500 TIGRFAMs TIGR00256 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00256 UniProtKB DTD_ECOLI http://www.uniprot.org/uniprot/DTD_ECOLI UniProtKB-AC P0A6M4 http://www.uniprot.org/uniprot/P0A6M4 charge swissprot:DTD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DTD_ECOLI eggNOG COG1490 http://eggnogapi.embl.de/nog_data/html/tree/COG1490 eggNOG ENOG4108YYA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108YYA epestfind swissprot:DTD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DTD_ECOLI garnier swissprot:DTD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DTD_ECOLI helixturnhelix swissprot:DTD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DTD_ECOLI hmoment swissprot:DTD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DTD_ECOLI iep swissprot:DTD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DTD_ECOLI inforesidue swissprot:DTD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DTD_ECOLI octanol swissprot:DTD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DTD_ECOLI pepcoil swissprot:DTD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DTD_ECOLI pepdigest swissprot:DTD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DTD_ECOLI pepinfo swissprot:DTD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DTD_ECOLI pepnet swissprot:DTD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DTD_ECOLI pepstats swissprot:DTD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DTD_ECOLI pepwheel swissprot:DTD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DTD_ECOLI pepwindow swissprot:DTD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DTD_ECOLI sigcleave swissprot:DTD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DTD_ECOLI ## Database ID URL or Descriptions # BioGrid 4259519 6 # EcoGene EG11513 yaaI # HAMAP MF_01372 UPF0412 # InterPro IPR020240 UPF0412_YaaI # Organism YAAI_ECOLI Escherichia coli (strain K12) # PATRIC 32115119 VBIEscCol129921_0011 # PIR C56688 C56688 # Pfam PF10807 DUF2541 # ProDom PD082838 UPF0412_protein_YaaI # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UPF0412 protein YaaI {ECO:0000255|HAMAP-Rule MF_01372} # RefSeq NP_414554 NC_000913.3 # RefSeq WP_000843565 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0412 family. {ECO:0000255|HAMAP- Rule MF_01372}. # eggNOG ENOG4108WTA Bacteria # eggNOG ENOG4111IQ3 LUCA BLAST swissprot:YAAI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAAI_ECOLI BioCyc ECOL316407:JW0012-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0012-MONOMER BioCyc EcoCyc:G8202-MONOMER http://biocyc.org/getid?id=EcoCyc:G8202-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X67700 http://www.ebi.ac.uk/ena/data/view/X67700 EchoBASE EB1475 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1475 EcoGene EG11513 http://www.ecogene.org/geneInfo.php?eg_id=EG11513 EnsemblBacteria AAC73124 http://www.ensemblgenomes.org/id/AAC73124 EnsemblBacteria AAC73124 http://www.ensemblgenomes.org/id/AAC73124 EnsemblBacteria BAE76029 http://www.ensemblgenomes.org/id/BAE76029 EnsemblBacteria BAE76029 http://www.ensemblgenomes.org/id/BAE76029 EnsemblBacteria BAE76029 http://www.ensemblgenomes.org/id/BAE76029 EnsemblBacteria b0013 http://www.ensemblgenomes.org/id/b0013 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 944751 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944751 HAMAP MF_01372 http://hamap.expasy.org/unirule/MF_01372 HOGENOM HOG000294394 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000294394&db=HOGENOM6 IntAct P28696 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P28696* InterPro IPR020240 http://www.ebi.ac.uk/interpro/entry/IPR020240 KEGG_Gene ecj:JW0012 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0012 KEGG_Gene eco:b0013 http://www.genome.jp/dbget-bin/www_bget?eco:b0013 OMA CVKKIAF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CVKKIAF PSORT swissprot:YAAI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAAI_ECOLI PSORT-B swissprot:YAAI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAAI_ECOLI PSORT2 swissprot:YAAI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAAI_ECOLI Pfam PF10807 http://pfam.xfam.org/family/PF10807 Phobius swissprot:YAAI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAAI_ECOLI ProteinModelPortal P28696 http://www.proteinmodelportal.org/query/uniprot/P28696 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8400364 http://www.ncbi.nlm.nih.gov/pubmed/8400364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414554 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414554 RefSeq WP_000843565 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000843565 STRING 511145.b0013 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0013&targetmode=cogs UniProtKB YAAI_ECOLI http://www.uniprot.org/uniprot/YAAI_ECOLI UniProtKB-AC P28696 http://www.uniprot.org/uniprot/P28696 charge swissprot:YAAI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAAI_ECOLI eggNOG ENOG4108WTA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108WTA eggNOG ENOG4111IQ3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111IQ3 epestfind swissprot:YAAI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAAI_ECOLI garnier swissprot:YAAI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAAI_ECOLI helixturnhelix swissprot:YAAI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAAI_ECOLI hmoment swissprot:YAAI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAAI_ECOLI iep swissprot:YAAI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAAI_ECOLI inforesidue swissprot:YAAI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAAI_ECOLI octanol swissprot:YAAI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAAI_ECOLI pepcoil swissprot:YAAI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAAI_ECOLI pepdigest swissprot:YAAI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAAI_ECOLI pepinfo swissprot:YAAI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAAI_ECOLI pepnet swissprot:YAAI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAAI_ECOLI pepstats swissprot:YAAI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAAI_ECOLI pepwheel swissprot:YAAI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAAI_ECOLI pepwindow swissprot:YAAI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAAI_ECOLI sigcleave swissprot:YAAI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAAI_ECOLI ## Database ID URL or Descriptions # FUNCTION TRAC_ECOLI Required for the assembly of mature F-pilin subunits into extended F pili. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_process GO:0000746 conjugation; IEA:UniProtKB-KW. # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.300 -; 2. # InterPro IPR002789 HerA_central # InterPro IPR014117 TraC-F-type # InterPro IPR025955 TraC/Conjuga_ATPase # InterPro IPR027417 P-loop_NTPase # Organism TRAC_ECOLI Escherichia coli (strain K12) # PIR JQ0813 S27572 # Pfam PF01935 DUF87 # Pfam PF11130 TraC_F_IV # RecName TRAC_ECOLI Protein TraC # RefSeq NP_061463 NC_002483.1 # RefSeq WP_001064243 NZ_CP014273.1 # SUBCELLULAR LOCATION TRAC_ECOLI Cell inner membrane; Peripheral membrane protein. # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR02746 TraC-F-type BLAST swissprot:TRAC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRAC_ECOLI DOI 10.1016/0378-1119(90)90354-T http://dx.doi.org/10.1016/0378-1119(90)90354-T EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL M30936 http://www.ebi.ac.uk/ena/data/view/M30936 EMBL M93106 http://www.ebi.ac.uk/ena/data/view/M93106 EMBL U01159 http://www.ebi.ac.uk/ena/data/view/U01159 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_process GO:0000746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000746 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 1263568 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263568 InterPro IPR002789 http://www.ebi.ac.uk/interpro/entry/IPR002789 InterPro IPR014117 http://www.ebi.ac.uk/interpro/entry/IPR014117 InterPro IPR025955 http://www.ebi.ac.uk/interpro/entry/IPR025955 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 OMA YAESPTI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YAESPTI PSORT swissprot:TRAC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRAC_ECOLI PSORT-B swissprot:TRAC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRAC_ECOLI PSORT2 swissprot:TRAC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRAC_ECOLI Pfam PF01935 http://pfam.xfam.org/family/PF01935 Pfam PF11130 http://pfam.xfam.org/family/PF11130 Phobius swissprot:TRAC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRAC_ECOLI ProteinModelPortal P18004 http://www.proteinmodelportal.org/query/uniprot/P18004 PubMed 1355084 http://www.ncbi.nlm.nih.gov/pubmed/1355084 PubMed 2265751 http://www.ncbi.nlm.nih.gov/pubmed/2265751 PubMed 7915817 http://www.ncbi.nlm.nih.gov/pubmed/7915817 RefSeq NP_061463 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061463 RefSeq WP_001064243 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001064243 SMR P18004 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P18004 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR02746 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02746 UniProtKB TRAC_ECOLI http://www.uniprot.org/uniprot/TRAC_ECOLI UniProtKB-AC P18004 http://www.uniprot.org/uniprot/P18004 charge swissprot:TRAC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRAC_ECOLI epestfind swissprot:TRAC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRAC_ECOLI garnier swissprot:TRAC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRAC_ECOLI helixturnhelix swissprot:TRAC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRAC_ECOLI hmoment swissprot:TRAC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRAC_ECOLI iep swissprot:TRAC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRAC_ECOLI inforesidue swissprot:TRAC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRAC_ECOLI octanol swissprot:TRAC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRAC_ECOLI pepcoil swissprot:TRAC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRAC_ECOLI pepdigest swissprot:TRAC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRAC_ECOLI pepinfo swissprot:TRAC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRAC_ECOLI pepnet swissprot:TRAC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRAC_ECOLI pepstats swissprot:TRAC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRAC_ECOLI pepwheel swissprot:TRAC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRAC_ECOLI pepwindow swissprot:TRAC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRAC_ECOLI sigcleave swissprot:TRAC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRAC_ECOLI ## Database ID URL or Descriptions # BioGrid 4261543 44 # EcoGene EG12338 yagA # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_process GO:0015074 DNA integration; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # Gene3D 1.10.10.60 -; 1. # Gene3D 3.30.420.10 -; 1. # IntAct P37007 6 # InterPro IPR001584 Integrase_cat-core # InterPro IPR009057 Homeodomain-like # InterPro IPR012337 RNaseH-like_dom # Organism YAGA_ECOLI Escherichia coli (strain K12) # PATRIC 32115655 VBIEscCol129921_0271 # PIR C64752 C64752 # PROSITE PS50994 INTEGRASE # Pfam PF00665 rve # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAGA_ECOLI Uncharacterized protein YagA # RefSeq NP_414801 NC_000913.3 # SEQUENCE CAUTION Sequence=L20943; Type=Frameshift; Positions=257; Evidence={ECO 0000305}; # SIMILARITY Contains 1 integrase catalytic domain. {ECO:0000255|PROSITE-ProRule PRU00457}. # SUPFAM SSF46689 SSF46689 # SUPFAM SSF53098 SSF53098 # eggNOG ENOG4108KQ5 Bacteria # eggNOG ENOG410XTHD LUCA BLAST swissprot:YAGA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAGA_ECOLI BioCyc ECOL316407:JW0260-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0260-MONOMER BioCyc EcoCyc:EG12338-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12338-MONOMER DIP DIP-11230N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11230N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L20943 http://www.ebi.ac.uk/ena/data/view/L20943 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EchoBASE EB2242 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2242 EcoGene EG12338 http://www.ecogene.org/geneInfo.php?eg_id=EG12338 EnsemblBacteria AAC73370 http://www.ensemblgenomes.org/id/AAC73370 EnsemblBacteria AAC73370 http://www.ensemblgenomes.org/id/AAC73370 EnsemblBacteria BAA77933 http://www.ensemblgenomes.org/id/BAA77933 EnsemblBacteria BAA77933 http://www.ensemblgenomes.org/id/BAA77933 EnsemblBacteria BAA77933 http://www.ensemblgenomes.org/id/BAA77933 EnsemblBacteria b0267 http://www.ensemblgenomes.org/id/b0267 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0015074 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015074 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 Gene3D 3.30.420.10 http://www.cathdb.info/version/latest/superfamily/3.30.420.10 GeneID 944937 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944937 HOGENOM HOG000267831 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267831&db=HOGENOM6 InParanoid P37007 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37007 IntAct P37007 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37007* InterPro IPR001584 http://www.ebi.ac.uk/interpro/entry/IPR001584 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR012337 http://www.ebi.ac.uk/interpro/entry/IPR012337 KEGG_Gene ecj:JW0260 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0260 KEGG_Gene eco:b0267 http://www.genome.jp/dbget-bin/www_bget?eco:b0267 MINT MINT-1304831 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1304831 OMA PWREVSV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PWREVSV PROSITE PS50994 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50994 PSORT swissprot:YAGA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAGA_ECOLI PSORT-B swissprot:YAGA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAGA_ECOLI PSORT2 swissprot:YAGA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAGA_ECOLI Pfam PF00665 http://pfam.xfam.org/family/PF00665 Phobius swissprot:YAGA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAGA_ECOLI PhylomeDB P37007 http://phylomedb.org/?seqid=P37007 ProteinModelPortal P37007 http://www.proteinmodelportal.org/query/uniprot/P37007 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8113168 http://www.ncbi.nlm.nih.gov/pubmed/8113168 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414801 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414801 SMR P37007 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37007 STRING 511145.b0267 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0267&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF53098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098 UniProtKB YAGA_ECOLI http://www.uniprot.org/uniprot/YAGA_ECOLI UniProtKB-AC P37007 http://www.uniprot.org/uniprot/P37007 charge swissprot:YAGA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAGA_ECOLI eggNOG ENOG4108KQ5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108KQ5 eggNOG ENOG410XTHD http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XTHD epestfind swissprot:YAGA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAGA_ECOLI garnier swissprot:YAGA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAGA_ECOLI helixturnhelix swissprot:YAGA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAGA_ECOLI hmoment swissprot:YAGA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAGA_ECOLI iep swissprot:YAGA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAGA_ECOLI inforesidue swissprot:YAGA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAGA_ECOLI octanol swissprot:YAGA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAGA_ECOLI pepcoil swissprot:YAGA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAGA_ECOLI pepdigest swissprot:YAGA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAGA_ECOLI pepinfo swissprot:YAGA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAGA_ECOLI pepnet swissprot:YAGA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAGA_ECOLI pepstats swissprot:YAGA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAGA_ECOLI pepwheel swissprot:YAGA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAGA_ECOLI pepwindow swissprot:YAGA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAGA_ECOLI sigcleave swissprot:YAGA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAGA_ECOLI ## Database ID URL or Descriptions # InterPro IPR009811 DUF1380 # Organism YUBF_ECOLI Escherichia coli (strain K12) # Pfam PF07128 DUF1380 # RecName YUBF_ECOLI Uncharacterized protein YubF # RefSeq NP_061433 NC_002483.1 # RefSeq WP_000274477 NZ_CP014273.1 BLAST swissprot:YUBF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YUBF_ECOLI DOI 10.1006/plas.1999.1390 http://dx.doi.org/10.1006/plas.1999.1390 EMBL AF106329 http://www.ebi.ac.uk/ena/data/view/AF106329 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1263532 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263532 InterPro IPR009811 http://www.ebi.ac.uk/interpro/entry/IPR009811 OMA AQYPGDT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AQYPGDT PSORT swissprot:YUBF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YUBF_ECOLI PSORT-B swissprot:YUBF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YUBF_ECOLI PSORT2 swissprot:YUBF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YUBF_ECOLI Pfam PF07128 http://pfam.xfam.org/family/PF07128 Phobius swissprot:YUBF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YUBF_ECOLI ProteinModelPortal Q9S4X0 http://www.proteinmodelportal.org/query/uniprot/Q9S4X0 PubMed 10366527 http://www.ncbi.nlm.nih.gov/pubmed/10366527 RefSeq NP_061433 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061433 RefSeq WP_000274477 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000274477 UniProtKB YUBF_ECOLI http://www.uniprot.org/uniprot/YUBF_ECOLI UniProtKB-AC Q9S4X0 http://www.uniprot.org/uniprot/Q9S4X0 charge swissprot:YUBF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YUBF_ECOLI epestfind swissprot:YUBF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YUBF_ECOLI garnier swissprot:YUBF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YUBF_ECOLI helixturnhelix swissprot:YUBF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YUBF_ECOLI hmoment swissprot:YUBF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YUBF_ECOLI iep swissprot:YUBF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YUBF_ECOLI inforesidue swissprot:YUBF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YUBF_ECOLI octanol swissprot:YUBF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YUBF_ECOLI pepcoil swissprot:YUBF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YUBF_ECOLI pepdigest swissprot:YUBF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YUBF_ECOLI pepinfo swissprot:YUBF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YUBF_ECOLI pepnet swissprot:YUBF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YUBF_ECOLI pepstats swissprot:YUBF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YUBF_ECOLI pepwheel swissprot:YUBF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YUBF_ECOLI pepwindow swissprot:YUBF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YUBF_ECOLI sigcleave swissprot:YUBF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YUBF_ECOLI ## Database ID URL or Descriptions # CATALYTIC ACTIVITY GLRK_ECOLI ATP + protein L-histidine = ADP + protein N- phospho-L-histidine. # DISRUPTION PHENOTYPE Mutants show decreased amounts of glmY. {ECO:0000269|PubMed 19843219}. # EcoGene EG13461 glrK # FUNCTION GLRK_ECOLI Member of the two-component regulatory system GlrR/GlrK that up-regulates transcription of the glmY sRNA when cells enter the stationary growth phase. Activates GlrR by phosphorylation. {ECO 0000269|PubMed 15522865, ECO 0000269|PubMed 19843219}. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0000155 phosphorelay sensor kinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0000160 phosphorelay signal transduction system; IDA:EcoCyc. # GO_process GO:0046777 protein autophosphorylation; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005622 intracellular # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0007165 signal transduction # Gene3D 1.10.287.130 -; 1. # Gene3D 3.30.565.10 -; 1. # InterPro IPR003594 HATPase_C # InterPro IPR003660 HAMP_dom # InterPro IPR003661 HisK_dim/P # InterPro IPR004358 Sig_transdc_His_kin-like_C # InterPro IPR005467 His_kinase_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01001 Protein kinases # KEGG_Brite ko02022 M00502 GlrK-GlrR (amino sugar metabolism) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # MISCELLANEOUS GLRK_ECOLI Not required for the regulation of the glmY-glmZ- glmS regulatory cascade by glucosamine-6-phosphate depletion. # Organism GLRK_ECOLI Escherichia coli (strain K12) # PATRIC 32120511 VBIEscCol129921_2658 # PIR C65033 C65033 # PRINTS PR00344 BCTRLSENSOR # PROSITE PS50109 HIS_KIN # PTM GLRK_ECOLI Autophosphorylated. # Pfam PF00512 HisKA # Pfam PF00672 HAMP # Pfam PF02518 HATPase_c # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLRK_ECOLI Sensor histidine kinase GlrK # RefSeq NP_417051 NC_000913.3 # RefSeq WP_001311037 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA79818.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Contains 1 histidine kinase domain. {ECO:0000255|PROSITE-ProRule PRU00107}. # SMART SM00387 HATPase_c # SMART SM00388 HisKA # SUBCELLULAR LOCATION GLRK_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF47384 SSF47384 # SUPFAM SSF55874 SSF55874 # eggNOG ENOG4107WP9 Bacteria # eggNOG ENOG410Y4CW LUCA BLAST swissprot:GLRK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLRK_ECOLI BioCyc ECOL316407:JW5407-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5407-MONOMER BioCyc EcoCyc:G7345-MONOMER http://biocyc.org/getid?id=EcoCyc:G7345-MONOMER COG COG0642 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0642 DIP DIP-12052N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12052N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M410104200 http://dx.doi.org/10.1074/jbc.M410104200 DOI 10.1111/j.1365-2958.2009.06918.x http://dx.doi.org/10.1111/j.1365-2958.2009.06918.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.13.3 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.13.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36841 http://www.ebi.ac.uk/ena/data/view/U36841 ENZYME 2.7.13.3 http://enzyme.expasy.org/EC/2.7.13.3 EchoBASE EB3234 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3234 EcoGene EG13461 http://www.ecogene.org/geneInfo.php?eg_id=EG13461 EnsemblBacteria AAC75609 http://www.ensemblgenomes.org/id/AAC75609 EnsemblBacteria AAC75609 http://www.ensemblgenomes.org/id/AAC75609 EnsemblBacteria BAE76732 http://www.ensemblgenomes.org/id/BAE76732 EnsemblBacteria BAE76732 http://www.ensemblgenomes.org/id/BAE76732 EnsemblBacteria BAE76732 http://www.ensemblgenomes.org/id/BAE76732 EnsemblBacteria b2556 http://www.ensemblgenomes.org/id/b2556 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0000155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000155 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0046777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046777 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 Gene3D 1.10.287.130 http://www.cathdb.info/version/latest/superfamily/1.10.287.130 Gene3D 3.30.565.10 http://www.cathdb.info/version/latest/superfamily/3.30.565.10 GeneID 947013 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947013 HOGENOM HOG000284457 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000284457&db=HOGENOM6 InParanoid P52101 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P52101 IntEnz 2.7.13.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.13.3 InterPro IPR003594 http://www.ebi.ac.uk/interpro/entry/IPR003594 InterPro IPR003660 http://www.ebi.ac.uk/interpro/entry/IPR003660 InterPro IPR003661 http://www.ebi.ac.uk/interpro/entry/IPR003661 InterPro IPR004358 http://www.ebi.ac.uk/interpro/entry/IPR004358 InterPro IPR005467 http://www.ebi.ac.uk/interpro/entry/IPR005467 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01001 http://www.genome.jp/dbget-bin/www_bget?ko01001 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW5407 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5407 KEGG_Gene eco:b2556 http://www.genome.jp/dbget-bin/www_bget?eco:b2556 KEGG_Orthology KO:K07711 http://www.genome.jp/dbget-bin/www_bget?KO:K07711 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA INFSHET http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=INFSHET PRINTS PR00344 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00344 PROSITE PS50109 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50109 PSORT swissprot:GLRK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLRK_ECOLI PSORT-B swissprot:GLRK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLRK_ECOLI PSORT2 swissprot:GLRK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLRK_ECOLI Pfam PF00512 http://pfam.xfam.org/family/PF00512 Pfam PF00672 http://pfam.xfam.org/family/PF00672 Pfam PF02518 http://pfam.xfam.org/family/PF02518 Phobius swissprot:GLRK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLRK_ECOLI PhylomeDB P52101 http://phylomedb.org/?seqid=P52101 ProteinModelPortal P52101 http://www.proteinmodelportal.org/query/uniprot/P52101 PubMed 15522865 http://www.ncbi.nlm.nih.gov/pubmed/15522865 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19843219 http://www.ncbi.nlm.nih.gov/pubmed/19843219 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417051 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417051 RefSeq WP_001311037 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001311037 SMART SM00387 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00387 SMART SM00388 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00388 SMR P52101 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P52101 STRING 511145.b2556 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2556&targetmode=cogs STRING COG0642 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0642&targetmode=cogs SUPFAM SSF47384 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47384 SUPFAM SSF55874 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55874 UniProtKB GLRK_ECOLI http://www.uniprot.org/uniprot/GLRK_ECOLI UniProtKB-AC P52101 http://www.uniprot.org/uniprot/P52101 charge swissprot:GLRK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLRK_ECOLI eggNOG ENOG4107WP9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107WP9 eggNOG ENOG410Y4CW http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y4CW epestfind swissprot:GLRK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLRK_ECOLI garnier swissprot:GLRK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLRK_ECOLI helixturnhelix swissprot:GLRK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLRK_ECOLI hmoment swissprot:GLRK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLRK_ECOLI iep swissprot:GLRK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLRK_ECOLI inforesidue swissprot:GLRK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLRK_ECOLI octanol swissprot:GLRK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLRK_ECOLI pepcoil swissprot:GLRK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLRK_ECOLI pepdigest swissprot:GLRK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLRK_ECOLI pepinfo swissprot:GLRK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLRK_ECOLI pepnet swissprot:GLRK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLRK_ECOLI pepstats swissprot:GLRK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLRK_ECOLI pepwheel swissprot:GLRK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLRK_ECOLI pepwindow swissprot:GLRK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLRK_ECOLI sigcleave swissprot:GLRK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLRK_ECOLI ## Database ID URL or Descriptions # ALTERNATIVE PRODUCTS CLPB_ECOLI Event=Alternative initiation; Named isoforms=2; Name=ClpB; IsoId=P63284-1; Sequence=Displayed; Name=ClpB-3; IsoId=P63284-2; Sequence=VSP_018703, VSP_018987; Note=ClpB-3 ATPase activity is not activated by proteins, as it is in ClpB.; # AltName CLPB_ECOLI Heat shock protein F84.1 # BioGrid 4260618 194 # BioGrid 851414 30 # DOMAIN CLPB_ECOLI The N-terminal domain probably functions as a substrate- discriminating domain, recruiting aggregated proteins to the ClpB hexamer and/or stabilizing bound proteins. The NBD2 domain is responsible for oligomerization, whereas the NBD1 domain stabilizes the hexamer probably in an ATP-dependent manner. The movement of the coiled-coil domain is essential for ClpB ability to rescue proteins from an aggregated state, probably by pulling apart large aggregated proteins, which are bound between the coiled-coils motifs of adjacent ClpB subunits in the functional hexamer. # EcoGene EG10157 clpB # FUNCTION CLPB_ECOLI Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK. {ECO 0000269|PubMed 10982797, ECO 0000269|PubMed 12624113, ECO 0000269|PubMed 14640692}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0042623 ATPase activity, coupled; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0006986 response to unfolded protein; IDA:EcoCyc. # GO_process GO:0009408 response to heat; IMP:EcoCyc. # GO_process GO:0016485 protein processing; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0051604 protein maturation # Gene3D 1.10.1780.10 -; 1. # Gene3D 3.40.50.300 -; 2. # INDUCTION CLPB_ECOLI By heat shock and other environmental stresses. # INTERACTION CLPB_ECOLI Self; NbExp=2; IntAct=EBI-546182, EBI-546182; P33014 yeeD; NbExp=3; IntAct=EBI-546182, EBI-9130839; # IntAct P63284 77 # InterPro IPR001270 ClpA/B # InterPro IPR003593 AAA+_ATPase # InterPro IPR003959 ATPase_AAA_core # InterPro IPR004176 Clp_N # InterPro IPR017730 Chaperonin_ClpB # InterPro IPR018368 ClpA/B_CS1 # InterPro IPR019489 Clp_ATPase_C # InterPro IPR027417 P-loop_NTPase # InterPro IPR028299 ClpA/B_CS2 # KEGG_Brite ko03110 Chaperones and folding catalysts # MISCELLANEOUS CLPB_ECOLI One peptide binds per ClpB hexamer; the binding site is formed only upon ATP-driven oligomerization. # Organism CLPB_ECOLI Escherichia coli (strain K12) # PATRIC 32120587 VBIEscCol129921_2692 # PDB 1JBK X-ray; 1.80 A; A=159-351 # PDB 1KHY X-ray; 1.95 A; A/B/C/D=1-148 # PDB 4CIU X-ray; 3.50 A; A=143-857 # PDB 4D2Q EM; 18.00 A; A/B/C/D/E/F=1-857 # PDB 4D2U EM; 17.00 A; A/B/C/D/E/F=1-857 # PDB 4D2X EM; 20.00 A; A/B/C/D/E/F=1-857 # PIR C65037 D35905 # PRINTS PR00300 CLPPROTEASEA # PROSITE PS00870 CLPAB_1 # PROSITE PS00871 CLPAB_2 # Pfam PF00004 AAA # Pfam PF02861 Clp_N; 2 # Pfam PF07724 AAA_2 # Pfam PF10431 ClpB_D2-small # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CLPB_ECOLI Chaperone protein ClpB # RefSeq NP_417083 NC_000913.3 # RefSeq WP_001235102 NZ_LN832404.1 # SIMILARITY Belongs to the ClpA/ClpB family. {ECO 0000305}. # SMART SM00382 AAA; 2 # SMART SM01086 ClpB_D2-small # SUBCELLULAR LOCATION CLPB_ECOLI Cytoplasm {ECO 0000269|PubMed 8376377}. # SUBUNIT Homohexamer. The oligomerization is ATP-dependent. {ECO:0000269|PubMed 11061966}. # SUPFAM SSF52540 SSF52540; 2 # SUPFAM SSF81923 SSF81923 # TIGRFAMs TIGR03346 chaperone_ClpB # eggNOG COG0542 LUCA # eggNOG ENOG4105C2Z Bacteria BLAST swissprot:CLPB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CLPB_ECOLI BioCyc ECOL316407:JW2573-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2573-MONOMER BioCyc EcoCyc:EG10157-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10157-MONOMER COG COG0542 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0542 DIP DIP-35844N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35844N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/jmbi.2000.4165 http://dx.doi.org/10.1006/jmbi.2000.4165 DOI 10.1016/S0006-291X(05)81326-9 http://dx.doi.org/10.1016/S0006-291X(05)81326-9 DOI 10.1016/S0022-2836(02)00188-2 http://dx.doi.org/10.1016/S0022-2836(02)00188-2 DOI 10.1016/S0022-2836(02)00591-0 http://dx.doi.org/10.1016/S0022-2836(02)00591-0 DOI 10.1016/S0969-2126(03)00030-3 http://dx.doi.org/10.1016/S0969-2126(03)00030-3 DOI 10.1021/bi026161s http://dx.doi.org/10.1021/bi026161s DOI 10.1021/bi035573d http://dx.doi.org/10.1021/bi035573d DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsmb787 http://dx.doi.org/10.1038/nsmb787 DOI 10.1073/pnas.87.9.3513 http://dx.doi.org/10.1073/pnas.87.9.3513 DOI 10.1074/jbc.M005211200 http://dx.doi.org/10.1074/jbc.M005211200 DOI 10.1074/jbc.M209686200 http://dx.doi.org/10.1074/jbc.M209686200 DOI 10.1074/jbc.M303653200 http://dx.doi.org/10.1074/jbc.M303653200 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/nar/10.10.3303 http://dx.doi.org/10.1093/nar/10.10.3303 DOI 10.1107/S0907444901017322 http://dx.doi.org/10.1107/S0907444901017322 DOI 10.1107/S0907444902006327 http://dx.doi.org/10.1107/S0907444902006327 DOI 10.1110/ps.03422604 http://dx.doi.org/10.1110/ps.03422604 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M29364 http://www.ebi.ac.uk/ena/data/view/M29364 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U50134 http://www.ebi.ac.uk/ena/data/view/U50134 EMBL V00350 http://www.ebi.ac.uk/ena/data/view/V00350 EMBL X57620 http://www.ebi.ac.uk/ena/data/view/X57620 EchoBASE EB0155 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0155 EcoGene EG10157 http://www.ecogene.org/geneInfo.php?eg_id=EG10157 EnsemblBacteria AAC75641 http://www.ensemblgenomes.org/id/AAC75641 EnsemblBacteria AAC75641 http://www.ensemblgenomes.org/id/AAC75641 EnsemblBacteria BAA16476 http://www.ensemblgenomes.org/id/BAA16476 EnsemblBacteria BAA16476 http://www.ensemblgenomes.org/id/BAA16476 EnsemblBacteria BAA16476 http://www.ensemblgenomes.org/id/BAA16476 EnsemblBacteria b2592 http://www.ensemblgenomes.org/id/b2592 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0042623 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042623 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0006986 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006986 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GO_process GO:0016485 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016485 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 Gene3D 1.10.1780.10 http://www.cathdb.info/version/latest/superfamily/1.10.1780.10 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947077 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947077 HOGENOM HOG000218211 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218211&db=HOGENOM6 InParanoid P63284 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P63284 IntAct P63284 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P63284* InterPro IPR001270 http://www.ebi.ac.uk/interpro/entry/IPR001270 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR003959 http://www.ebi.ac.uk/interpro/entry/IPR003959 InterPro IPR004176 http://www.ebi.ac.uk/interpro/entry/IPR004176 InterPro IPR017730 http://www.ebi.ac.uk/interpro/entry/IPR017730 InterPro IPR018368 http://www.ebi.ac.uk/interpro/entry/IPR018368 InterPro IPR019489 http://www.ebi.ac.uk/interpro/entry/IPR019489 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR028299 http://www.ebi.ac.uk/interpro/entry/IPR028299 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW2573 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2573 KEGG_Gene eco:b2592 http://www.genome.jp/dbget-bin/www_bget?eco:b2592 KEGG_Orthology KO:K03695 http://www.genome.jp/dbget-bin/www_bget?KO:K03695 MINT MINT-1222117 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1222117 OMA PVERILM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PVERILM PDB 1JBK http://www.ebi.ac.uk/pdbe-srv/view/entry/1JBK PDB 1KHY http://www.ebi.ac.uk/pdbe-srv/view/entry/1KHY PDB 4CIU http://www.ebi.ac.uk/pdbe-srv/view/entry/4CIU PDB 4D2Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4D2Q PDB 4D2U http://www.ebi.ac.uk/pdbe-srv/view/entry/4D2U PDB 4D2X http://www.ebi.ac.uk/pdbe-srv/view/entry/4D2X PDBsum 1JBK http://www.ebi.ac.uk/pdbsum/1JBK PDBsum 1KHY http://www.ebi.ac.uk/pdbsum/1KHY PDBsum 4CIU http://www.ebi.ac.uk/pdbsum/4CIU PDBsum 4D2Q http://www.ebi.ac.uk/pdbsum/4D2Q PDBsum 4D2U http://www.ebi.ac.uk/pdbsum/4D2U PDBsum 4D2X http://www.ebi.ac.uk/pdbsum/4D2X PRINTS PR00300 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00300 PROSITE PS00870 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00870 PROSITE PS00871 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00871 PSORT swissprot:CLPB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CLPB_ECOLI PSORT-B swissprot:CLPB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CLPB_ECOLI PSORT2 swissprot:CLPB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CLPB_ECOLI Pfam PF00004 http://pfam.xfam.org/family/PF00004 Pfam PF02861 http://pfam.xfam.org/family/PF02861 Pfam PF07724 http://pfam.xfam.org/family/PF07724 Pfam PF10431 http://pfam.xfam.org/family/PF10431 Phobius swissprot:CLPB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CLPB_ECOLI PhylomeDB P63284 http://phylomedb.org/?seqid=P63284 ProteinModelPortal P63284 http://www.proteinmodelportal.org/query/uniprot/P63284 PubMed 10982797 http://www.ncbi.nlm.nih.gov/pubmed/10982797 PubMed 11061966 http://www.ncbi.nlm.nih.gov/pubmed/11061966 PubMed 11717522 http://www.ncbi.nlm.nih.gov/pubmed/11717522 PubMed 12037306 http://www.ncbi.nlm.nih.gov/pubmed/12037306 PubMed 12054807 http://www.ncbi.nlm.nih.gov/pubmed/12054807 PubMed 12139937 http://www.ncbi.nlm.nih.gov/pubmed/12139937 PubMed 12220194 http://www.ncbi.nlm.nih.gov/pubmed/12220194 PubMed 12623019 http://www.ncbi.nlm.nih.gov/pubmed/12623019 PubMed 12624113 http://www.ncbi.nlm.nih.gov/pubmed/12624113 PubMed 12805357 http://www.ncbi.nlm.nih.gov/pubmed/12805357 PubMed 14640692 http://www.ncbi.nlm.nih.gov/pubmed/14640692 PubMed 14978298 http://www.ncbi.nlm.nih.gov/pubmed/14978298 PubMed 15208691 http://www.ncbi.nlm.nih.gov/pubmed/15208691 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 1906060 http://www.ncbi.nlm.nih.gov/pubmed/1906060 PubMed 1953774 http://www.ncbi.nlm.nih.gov/pubmed/1953774 PubMed 2066329 http://www.ncbi.nlm.nih.gov/pubmed/2066329 PubMed 2185473 http://www.ncbi.nlm.nih.gov/pubmed/2185473 PubMed 6285294 http://www.ncbi.nlm.nih.gov/pubmed/6285294 PubMed 8376377 http://www.ncbi.nlm.nih.gov/pubmed/8376377 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417083 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417083 RefSeq WP_001235102 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001235102 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMART SM01086 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01086 SMR P63284 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P63284 STRING 511145.b2592 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2592&targetmode=cogs STRING COG0542 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0542&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SUPFAM SSF81923 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81923 SWISS-2DPAGE P63284 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P63284 TIGRFAMs TIGR03346 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03346 UniProtKB CLPB_ECOLI http://www.uniprot.org/uniprot/CLPB_ECOLI UniProtKB-AC P63284 http://www.uniprot.org/uniprot/P63284 charge swissprot:CLPB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CLPB_ECOLI eggNOG COG0542 http://eggnogapi.embl.de/nog_data/html/tree/COG0542 eggNOG ENOG4105C2Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C2Z epestfind swissprot:CLPB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CLPB_ECOLI garnier swissprot:CLPB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CLPB_ECOLI helixturnhelix swissprot:CLPB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CLPB_ECOLI hmoment swissprot:CLPB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CLPB_ECOLI iep swissprot:CLPB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CLPB_ECOLI inforesidue swissprot:CLPB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CLPB_ECOLI octanol swissprot:CLPB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CLPB_ECOLI pepcoil swissprot:CLPB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CLPB_ECOLI pepdigest swissprot:CLPB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CLPB_ECOLI pepinfo swissprot:CLPB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CLPB_ECOLI pepnet swissprot:CLPB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CLPB_ECOLI pepstats swissprot:CLPB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CLPB_ECOLI pepwheel swissprot:CLPB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CLPB_ECOLI pepwindow swissprot:CLPB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CLPB_ECOLI sigcleave swissprot:CLPB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CLPB_ECOLI ## Database ID URL or Descriptions # BioGrid 4262677 7 # EcoGene EG11948 nrfE # FUNCTION NRFE_ECOLI May be required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015232 heme transporter activity; IEA:InterPro. # GO_function GO:0020037 heme binding; IEA:InterPro. # GO_process GO:0018378 cytochrome c-heme linkage via heme-L-cysteine; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0006464 cellular protein modification process # InterPro IPR002541 Cyt_c_assembly # InterPro IPR003567 Cyt_c_biogenesis # InterPro IPR003568 Cyt_c_biogenesis_CcmF # InterPro IPR003570 Cyt_c_biogenesis_NrfE # InterPro IPR032523 CcmF_C # Organism NRFE_ECOLI Escherichia coli (strain K12) # PATRIC 32123697 VBIEscCol129921_4197 # PIR A65216 E57987 # PRINTS PR01410 CCBIOGENESIS # PRINTS PR01413 NRFEBIOGNSIS # Pfam PF01578 Cytochrom_C_asm # Pfam PF16327 CcmF_C; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NRFE_ECOLI Cytochrome c-type biogenesis protein NrfE # RefSeq NP_418498 NC_000913.3 # SIMILARITY Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family. {ECO 0000305}. # SUBCELLULAR LOCATION NRFE_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # TIGRFAMs TIGR00353 nrfE # eggNOG COG1138 LUCA # eggNOG ENOG4108QKW Bacteria BLAST swissprot:NRFE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NRFE_ECOLI BioCyc ECOL316407:JW4035-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4035-MONOMER BioCyc EcoCyc:EG11948-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11948-MONOMER COG COG1138 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1138 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1111/j.1365-2958.1994.tb01004.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb01004.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X72298 http://www.ebi.ac.uk/ena/data/view/X72298 EchoBASE EB1891 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1891 EcoGene EG11948 http://www.ecogene.org/geneInfo.php?eg_id=EG11948 EnsemblBacteria AAD13457 http://www.ensemblgenomes.org/id/AAD13457 EnsemblBacteria AAD13457 http://www.ensemblgenomes.org/id/AAD13457 EnsemblBacteria BAE78076 http://www.ensemblgenomes.org/id/BAE78076 EnsemblBacteria BAE78076 http://www.ensemblgenomes.org/id/BAE78076 EnsemblBacteria BAE78076 http://www.ensemblgenomes.org/id/BAE78076 EnsemblBacteria b4074 http://www.ensemblgenomes.org/id/b4074 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015232 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015232 GO_function GO:0020037 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0020037 GO_process GO:0018378 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018378 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GeneID 948579 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948579 HOGENOM HOG000274659 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000274659&db=HOGENOM6 InParanoid P32710 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32710 InterPro IPR002541 http://www.ebi.ac.uk/interpro/entry/IPR002541 InterPro IPR003567 http://www.ebi.ac.uk/interpro/entry/IPR003567 InterPro IPR003568 http://www.ebi.ac.uk/interpro/entry/IPR003568 InterPro IPR003570 http://www.ebi.ac.uk/interpro/entry/IPR003570 InterPro IPR032523 http://www.ebi.ac.uk/interpro/entry/IPR032523 KEGG_Gene ecj:JW4035 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4035 KEGG_Gene eco:b4074 http://www.genome.jp/dbget-bin/www_bget?eco:b4074 KEGG_Orthology KO:K04016 http://www.genome.jp/dbget-bin/www_bget?KO:K04016 KEGG_Reaction rn:R05712 http://www.genome.jp/dbget-bin/www_bget?rn:R05712 OMA IPERRYY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IPERRYY PRINTS PR01410 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01410 PRINTS PR01413 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01413 PSORT swissprot:NRFE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NRFE_ECOLI PSORT-B swissprot:NRFE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NRFE_ECOLI PSORT2 swissprot:NRFE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NRFE_ECOLI Pfam PF01578 http://pfam.xfam.org/family/PF01578 Pfam PF16327 http://pfam.xfam.org/family/PF16327 Phobius swissprot:NRFE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NRFE_ECOLI PhylomeDB P32710 http://phylomedb.org/?seqid=P32710 ProteinModelPortal P32710 http://www.proteinmodelportal.org/query/uniprot/P32710 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8057835 http://www.ncbi.nlm.nih.gov/pubmed/8057835 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418498 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418498 STRING 511145.b4074 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4074&targetmode=cogs STRING COG1138 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1138&targetmode=cogs TIGRFAMs TIGR00353 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00353 UniProtKB NRFE_ECOLI http://www.uniprot.org/uniprot/NRFE_ECOLI UniProtKB-AC P32710 http://www.uniprot.org/uniprot/P32710 charge swissprot:NRFE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NRFE_ECOLI eggNOG COG1138 http://eggnogapi.embl.de/nog_data/html/tree/COG1138 eggNOG ENOG4108QKW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108QKW epestfind swissprot:NRFE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NRFE_ECOLI garnier swissprot:NRFE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NRFE_ECOLI helixturnhelix swissprot:NRFE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NRFE_ECOLI hmoment swissprot:NRFE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NRFE_ECOLI iep swissprot:NRFE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NRFE_ECOLI inforesidue swissprot:NRFE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NRFE_ECOLI octanol swissprot:NRFE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NRFE_ECOLI pepcoil swissprot:NRFE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NRFE_ECOLI pepdigest swissprot:NRFE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NRFE_ECOLI pepinfo swissprot:NRFE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NRFE_ECOLI pepnet swissprot:NRFE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NRFE_ECOLI pepstats swissprot:NRFE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NRFE_ECOLI pepwheel swissprot:NRFE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NRFE_ECOLI pepwindow swissprot:NRFE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NRFE_ECOLI sigcleave swissprot:NRFE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NRFE_ECOLI ## Database ID URL or Descriptions # AltName NHAR_ECOLI Na(+)/H(+) antiporter regulatory protein # BioGrid 4259724 3 # EcoGene EG11078 nhaR # FUNCTION NHAR_ECOLI Plays a role in the positive regulation of NhaA. {ECO 0000269|PubMed 1316901}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # IntAct P0A9G2 2 # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR005119 LysR_subst-bd # InterPro IPR011991 WHTH_DNA-bd_dom # KEGG_Brite ko03000 Transcription factors # Organism NHAR_ECOLI Escherichia coli (strain K12) # PATRIC 32115131 VBIEscCol129921_0017 # PROSITE PS50931 HTH_LYSR # Pfam PF00126 HTH_1 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NHAR_ECOLI Transcriptional activator protein NhaR # RefSeq NP_414561 NC_000913.3 # SIMILARITY Contains 1 HTH lysR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00253}. # SUBCELLULAR LOCATION NHAR_ECOLI Cytoplasm. # SUPFAM SSF46785 SSF46785 # eggNOG COG0583 LUCA # eggNOG ENOG41063Z6 Bacteria BLAST swissprot:NHAR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NHAR_ECOLI BioCyc ECOL316407:JW0019-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0019-MONOMER BioCyc EcoCyc:PD00474 http://biocyc.org/getid?id=EcoCyc:PD00474 COG COG0583 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0583 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.85.18.6602 http://dx.doi.org/10.1073/pnas.85.18.6602 DOI 10.1093/nar/14.17.6965 http://dx.doi.org/10.1093/nar/14.17.6965 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L24072 http://www.ebi.ac.uk/ena/data/view/L24072 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X04382 http://www.ebi.ac.uk/ena/data/view/X04382 EchoBASE EB1070 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1070 EcoGene EG11078 http://www.ecogene.org/geneInfo.php?eg_id=EG11078 EnsemblBacteria AAC73131 http://www.ensemblgenomes.org/id/AAC73131 EnsemblBacteria AAC73131 http://www.ensemblgenomes.org/id/AAC73131 EnsemblBacteria BAE76032 http://www.ensemblgenomes.org/id/BAE76032 EnsemblBacteria BAE76032 http://www.ensemblgenomes.org/id/BAE76032 EnsemblBacteria BAE76032 http://www.ensemblgenomes.org/id/BAE76032 EnsemblBacteria b0020 http://www.ensemblgenomes.org/id/b0020 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 944757 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944757 HOGENOM HOG000233515 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000233515&db=HOGENOM6 InParanoid P0A9G2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9G2 IntAct P0A9G2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9G2* InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW0019 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0019 KEGG_Gene eco:b0020 http://www.genome.jp/dbget-bin/www_bget?eco:b0020 KEGG_Orthology KO:K03717 http://www.genome.jp/dbget-bin/www_bget?KO:K03717 OMA YYFWHVC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YYFWHVC PROSITE PS50931 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50931 PSORT swissprot:NHAR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NHAR_ECOLI PSORT-B swissprot:NHAR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NHAR_ECOLI PSORT2 swissprot:NHAR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NHAR_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:NHAR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NHAR_ECOLI PhylomeDB P0A9G2 http://phylomedb.org/?seqid=P0A9G2 ProteinModelPortal P0A9G2 http://www.proteinmodelportal.org/query/uniprot/P0A9G2 PubMed 1316901 http://www.ncbi.nlm.nih.gov/pubmed/1316901 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2429258 http://www.ncbi.nlm.nih.gov/pubmed/2429258 PubMed 3413113 http://www.ncbi.nlm.nih.gov/pubmed/3413113 PubMed 8168494 http://www.ncbi.nlm.nih.gov/pubmed/8168494 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414561 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414561 SMR P0A9G2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9G2 STRING 511145.b0020 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0020&targetmode=cogs STRING COG0583 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0583&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB NHAR_ECOLI http://www.uniprot.org/uniprot/NHAR_ECOLI UniProtKB-AC P0A9G2 http://www.uniprot.org/uniprot/P0A9G2 charge swissprot:NHAR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NHAR_ECOLI eggNOG COG0583 http://eggnogapi.embl.de/nog_data/html/tree/COG0583 eggNOG ENOG41063Z6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41063Z6 epestfind swissprot:NHAR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NHAR_ECOLI garnier swissprot:NHAR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NHAR_ECOLI helixturnhelix swissprot:NHAR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NHAR_ECOLI hmoment swissprot:NHAR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NHAR_ECOLI iep swissprot:NHAR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NHAR_ECOLI inforesidue swissprot:NHAR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NHAR_ECOLI octanol swissprot:NHAR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NHAR_ECOLI pepcoil swissprot:NHAR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NHAR_ECOLI pepdigest swissprot:NHAR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NHAR_ECOLI pepinfo swissprot:NHAR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NHAR_ECOLI pepnet swissprot:NHAR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NHAR_ECOLI pepstats swissprot:NHAR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NHAR_ECOLI pepwheel swissprot:NHAR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NHAR_ECOLI pepwindow swissprot:NHAR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NHAR_ECOLI sigcleave swissprot:NHAR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NHAR_ECOLI ## Database ID URL or Descriptions # BioGrid 4262872 11 # EcoGene EG13894 ycgM # GO_function GO:0003824 catalytic activity; IEA:InterPro. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0008152 metabolic process; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # Gene3D 3.90.850.10 -; 1. # IntAct P76004 3 # InterPro IPR011234 Fumarylacetoacetase_C-rel # Organism YCGM_ECOLI Escherichia coli (strain K12) # PATRIC 32117606 VBIEscCol129921_1225 # PDB 1NR9 X-ray; 2.70 A; A/B/C/D=1-219 # PIR A64864 A64864 # Pfam PF01557 FAA_hydrolase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCGM_ECOLI Uncharacterized protein YcgM # RefSeq NP_415698 NC_000913.3 # RefSeq WP_000284280 NZ_LN832404.1 # SIMILARITY Belongs to the FAH family. {ECO 0000305}. # SUPFAM SSF56529 SSF56529 # eggNOG COG0179 LUCA # eggNOG ENOG4105FBJ Bacteria BLAST swissprot:YCGM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCGM_ECOLI BioCyc ECOL316407:JW1169-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1169-MONOMER BioCyc EcoCyc:G6617-MONOMER http://biocyc.org/getid?id=EcoCyc:G6617-MONOMER DIP DIP-11558N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11558N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1432-1327.2000.01296.x http://dx.doi.org/10.1046/j.1432-1327.2000.01296.x DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3653 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3653 EcoGene EG13894 http://www.ecogene.org/geneInfo.php?eg_id=EG13894 EnsemblBacteria AAC74264 http://www.ensemblgenomes.org/id/AAC74264 EnsemblBacteria AAC74264 http://www.ensemblgenomes.org/id/AAC74264 EnsemblBacteria BAA36014 http://www.ensemblgenomes.org/id/BAA36014 EnsemblBacteria BAA36014 http://www.ensemblgenomes.org/id/BAA36014 EnsemblBacteria BAA36014 http://www.ensemblgenomes.org/id/BAA36014 EnsemblBacteria b1180 http://www.ensemblgenomes.org/id/b1180 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003824 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003824 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0008152 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008152 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.90.850.10 http://www.cathdb.info/version/latest/superfamily/3.90.850.10 GeneID 946115 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946115 HOGENOM HOG000063753 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000063753&db=HOGENOM6 InParanoid P76004 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76004 IntAct P76004 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76004* InterPro IPR011234 http://www.ebi.ac.uk/interpro/entry/IPR011234 KEGG_Gene ecj:JW1169 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1169 KEGG_Gene eco:b1180 http://www.genome.jp/dbget-bin/www_bget?eco:b1180 OMA LHAPIPK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LHAPIPK PDB 1NR9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1NR9 PDBsum 1NR9 http://www.ebi.ac.uk/pdbsum/1NR9 PSORT swissprot:YCGM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCGM_ECOLI PSORT-B swissprot:YCGM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCGM_ECOLI PSORT2 swissprot:YCGM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCGM_ECOLI Pfam PF01557 http://pfam.xfam.org/family/PF01557 Phobius swissprot:YCGM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCGM_ECOLI PhylomeDB P76004 http://phylomedb.org/?seqid=P76004 ProteinModelPortal P76004 http://www.proteinmodelportal.org/query/uniprot/P76004 PubMed 10806384 http://www.ncbi.nlm.nih.gov/pubmed/10806384 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415698 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415698 RefSeq WP_000284280 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000284280 SMR P76004 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76004 STRING 511145.b1180 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1180&targetmode=cogs SUPFAM SSF56529 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56529 UniProtKB YCGM_ECOLI http://www.uniprot.org/uniprot/YCGM_ECOLI UniProtKB-AC P76004 http://www.uniprot.org/uniprot/P76004 charge swissprot:YCGM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCGM_ECOLI eggNOG COG0179 http://eggnogapi.embl.de/nog_data/html/tree/COG0179 eggNOG ENOG4105FBJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FBJ epestfind swissprot:YCGM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCGM_ECOLI garnier swissprot:YCGM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCGM_ECOLI helixturnhelix swissprot:YCGM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCGM_ECOLI hmoment swissprot:YCGM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCGM_ECOLI iep swissprot:YCGM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCGM_ECOLI inforesidue swissprot:YCGM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCGM_ECOLI octanol swissprot:YCGM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCGM_ECOLI pepcoil swissprot:YCGM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCGM_ECOLI pepdigest swissprot:YCGM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCGM_ECOLI pepinfo swissprot:YCGM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCGM_ECOLI pepnet swissprot:YCGM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCGM_ECOLI pepstats swissprot:YCGM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCGM_ECOLI pepwheel swissprot:YCGM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCGM_ECOLI pepwindow swissprot:YCGM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCGM_ECOLI sigcleave swissprot:YCGM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCGM_ECOLI ## Database ID URL or Descriptions # BioGrid 4259787 6 # EcoGene EG13560 yagU # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0010447 response to acidic pH; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0008150 biological_process # InterPro IPR009898 DUF1440 # Organism YAGU_ECOLI Escherichia coli (strain K12) # PATRIC 32115697 VBIEscCol129921_0291 # PIR G64754 G64754 # Pfam PF07274 DUF1440 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAGU_ECOLI Inner membrane protein YagU # RefSeq NP_414821 NC_000913.3 # RefSeq WP_001019920 NZ_LN832404.1 # SUBCELLULAR LOCATION YAGU_ECOLI Cell inner membrane {ECO 0000269|PubMed 16079137}; Multi-pass membrane protein {ECO 0000269|PubMed 16079137}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 16079137}. # eggNOG COG3477 LUCA # eggNOG ENOG4105R3P Bacteria BLAST swissprot:YAGU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAGU_ECOLI BioCyc ECOL316407:JW0281-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0281-MONOMER BioCyc EcoCyc:G6158-MONOMER http://biocyc.org/getid?id=EcoCyc:G6158-MONOMER COG COG3477 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3477 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB3330 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3330 EcoGene EG13560 http://www.ecogene.org/geneInfo.php?eg_id=EG13560 EnsemblBacteria AAC73390 http://www.ensemblgenomes.org/id/AAC73390 EnsemblBacteria AAC73390 http://www.ensemblgenomes.org/id/AAC73390 EnsemblBacteria BAE76071 http://www.ensemblgenomes.org/id/BAE76071 EnsemblBacteria BAE76071 http://www.ensemblgenomes.org/id/BAE76071 EnsemblBacteria BAE76071 http://www.ensemblgenomes.org/id/BAE76071 EnsemblBacteria b0287 http://www.ensemblgenomes.org/id/b0287 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0010447 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010447 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 945677 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945677 HOGENOM HOG000117233 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117233&db=HOGENOM6 InterPro IPR009898 http://www.ebi.ac.uk/interpro/entry/IPR009898 KEGG_Gene ecj:JW0281 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0281 KEGG_Gene eco:b0287 http://www.genome.jp/dbget-bin/www_bget?eco:b0287 KEGG_Orthology KO:K08996 http://www.genome.jp/dbget-bin/www_bget?KO:K08996 OMA EIPFPPR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EIPFPPR PSORT swissprot:YAGU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAGU_ECOLI PSORT-B swissprot:YAGU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAGU_ECOLI PSORT2 swissprot:YAGU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAGU_ECOLI Pfam PF07274 http://pfam.xfam.org/family/PF07274 Phobius swissprot:YAGU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAGU_ECOLI ProteinModelPortal P0AAA1 http://www.proteinmodelportal.org/query/uniprot/P0AAA1 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414821 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414821 RefSeq WP_001019920 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001019920 STRING 511145.b0287 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0287&targetmode=cogs STRING COG3477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3477&targetmode=cogs UniProtKB YAGU_ECOLI http://www.uniprot.org/uniprot/YAGU_ECOLI UniProtKB-AC P0AAA1 http://www.uniprot.org/uniprot/P0AAA1 charge swissprot:YAGU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAGU_ECOLI eggNOG COG3477 http://eggnogapi.embl.de/nog_data/html/tree/COG3477 eggNOG ENOG4105R3P http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105R3P epestfind swissprot:YAGU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAGU_ECOLI garnier swissprot:YAGU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAGU_ECOLI helixturnhelix swissprot:YAGU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAGU_ECOLI hmoment swissprot:YAGU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAGU_ECOLI iep swissprot:YAGU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAGU_ECOLI inforesidue swissprot:YAGU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAGU_ECOLI octanol swissprot:YAGU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAGU_ECOLI pepcoil swissprot:YAGU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAGU_ECOLI pepdigest swissprot:YAGU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAGU_ECOLI pepinfo swissprot:YAGU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAGU_ECOLI pepnet swissprot:YAGU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAGU_ECOLI pepstats swissprot:YAGU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAGU_ECOLI pepwheel swissprot:YAGU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAGU_ECOLI pepwindow swissprot:YAGU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAGU_ECOLI sigcleave swissprot:YAGU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAGU_ECOLI ## Database ID URL or Descriptions # BioGrid 4263096 226 # DISRUPTION PHENOTYPE Disruption of both secD and SecF confers cold-sensitive growth (strain secD1(Cs)). {ECO:0000269|PubMed 2170107}. # EcoGene EG10938 secD # FUNCTION SECD_ECOLI Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. The large periplasmic domain is thought to have a base and head domain joined by a hinge; movement of the hinge may be coupled to both proton transport and protein export, with the head domain capturing substrate, and a conformational change preventing backward movement and driving forward movement. Expression of V.alginolyticus SecD and SecF in E.coli confers Na(+)-dependent protein export, strongly suggesting SecDF functions via cation-coupled protein translocation. {ECO 0000269|PubMed 21562494}. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity; IEA:InterPro. # GO_process GO:0006605 protein targeting; IEA:UniProtKB-HAMAP. # GO_process GO:0015031 protein transport; IMP:EcoliWiki. # GO_process GO:0043952 protein transport by the Sec complex; IEA:UniProtKB-HAMAP. # GO_process GO:0065002 intracellular protein transmembrane transport; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005622 intracellular # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0008565 protein transporter activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006605 protein targeting # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # HAMAP MF_01463_B SecD_B # INTERACTION SECD_ECOLI P07395 pheT; NbExp=3; IntAct=EBI-555724, EBI-555713; # IntAct P0AG90 10 # InterPro IPR005791 SecD # InterPro IPR022645 SecD/SecF_bac # InterPro IPR022646 SecD/SecF_CS # InterPro IPR022813 SecD/SecF_arch_bac # InterPro IPR027398 SecD-TM # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02044 M00335 Sec (secretion) system # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko03060 Protein export # KEGG_Pathway ko03070 Bacterial secretion system # Organism SECD_ECOLI Escherichia coli (strain K12) # PATRIC 32115965 VBIEscCol129921_0424 # PIR H64769 H64769 # Pfam PF02355 SecD_SecF # Pfam PF07549 Sec_GG # Pfam PF13721 SecD-TM1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SECD_ECOLI Protein translocase subunit SecD # RefSeq NP_414942 NC_000913.3 # RefSeq WP_000934822 NZ_LN832404.1 # SIMILARITY Belongs to the SecD/SecF family. SecD subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION SECD_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 16079137}; Multi- pass membrane protein {ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 16079137}. # SUBUNIT SECD_ECOLI Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC. # TCDB 2.A.6.4 the resistance-nodulation-cell division (rnd) superfamily # TIGRFAMs TIGR00916 2A0604s01 # TIGRFAMs TIGR01129 secD # eggNOG COG0342 LUCA # eggNOG ENOG4107QN8 Bacteria BLAST swissprot:SECD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SECD_ECOLI BioCyc ECOL316407:JW0398-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0398-MONOMER BioCyc EcoCyc:SECD http://biocyc.org/getid?id=EcoCyc:SECD COG COG0342 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0342 DIP DIP-35837N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35837N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature09980 http://dx.doi.org/10.1038/nature09980 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL S68715 http://www.ebi.ac.uk/ena/data/view/S68715 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL X56175 http://www.ebi.ac.uk/ena/data/view/X56175 EchoBASE EB0931 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0931 EcoGene EG10938 http://www.ecogene.org/geneInfo.php?eg_id=EG10938 EnsemblBacteria AAC73511 http://www.ensemblgenomes.org/id/AAC73511 EnsemblBacteria AAC73511 http://www.ensemblgenomes.org/id/AAC73511 EnsemblBacteria BAE76188 http://www.ensemblgenomes.org/id/BAE76188 EnsemblBacteria BAE76188 http://www.ensemblgenomes.org/id/BAE76188 EnsemblBacteria BAE76188 http://www.ensemblgenomes.org/id/BAE76188 EnsemblBacteria b0408 http://www.ensemblgenomes.org/id/b0408 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015450 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015450 GO_process GO:0006605 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006605 GO_process GO:0015031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031 GO_process GO:0043952 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043952 GO_process GO:0065002 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0065002 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006605 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006605 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 949133 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949133 HAMAP MF_01463_B http://hamap.expasy.org/unirule/MF_01463_B HOGENOM HOG000018637 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000018637&db=HOGENOM6 InParanoid P0AG90 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AG90 IntAct P0AG90 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AG90* InterPro IPR005791 http://www.ebi.ac.uk/interpro/entry/IPR005791 InterPro IPR022645 http://www.ebi.ac.uk/interpro/entry/IPR022645 InterPro IPR022646 http://www.ebi.ac.uk/interpro/entry/IPR022646 InterPro IPR022813 http://www.ebi.ac.uk/interpro/entry/IPR022813 InterPro IPR027398 http://www.ebi.ac.uk/interpro/entry/IPR027398 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW0398 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0398 KEGG_Gene eco:b0408 http://www.genome.jp/dbget-bin/www_bget?eco:b0408 KEGG_Orthology KO:K03072 http://www.genome.jp/dbget-bin/www_bget?KO:K03072 KEGG_Pathway ko03060 http://www.genome.jp/kegg-bin/show_pathway?ko03060 KEGG_Pathway ko03070 http://www.genome.jp/kegg-bin/show_pathway?ko03070 MINT MINT-1309074 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1309074 OMA AAPMEII http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AAPMEII PSORT swissprot:SECD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SECD_ECOLI PSORT-B swissprot:SECD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SECD_ECOLI PSORT2 swissprot:SECD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SECD_ECOLI Pfam PF02355 http://pfam.xfam.org/family/PF02355 Pfam PF07549 http://pfam.xfam.org/family/PF07549 Pfam PF13721 http://pfam.xfam.org/family/PF13721 Phobius swissprot:SECD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SECD_ECOLI PhylomeDB P0AG90 http://phylomedb.org/?seqid=P0AG90 ProteinModelPortal P0AG90 http://www.proteinmodelportal.org/query/uniprot/P0AG90 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21562494 http://www.ncbi.nlm.nih.gov/pubmed/21562494 PubMed 2170107 http://www.ncbi.nlm.nih.gov/pubmed/2170107 PubMed 2249673 http://www.ncbi.nlm.nih.gov/pubmed/2249673 PubMed 7507921 http://www.ncbi.nlm.nih.gov/pubmed/7507921 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414942 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414942 RefSeq WP_000934822 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000934822 STRING 511145.b0408 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0408&targetmode=cogs STRING COG0342 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0342&targetmode=cogs TCDB 2.A.6.4 http://www.tcdb.org/search/result.php?tc=2.A.6.4 TIGRFAMs TIGR00916 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00916 TIGRFAMs TIGR01129 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01129 UniProtKB SECD_ECOLI http://www.uniprot.org/uniprot/SECD_ECOLI UniProtKB-AC P0AG90 http://www.uniprot.org/uniprot/P0AG90 charge swissprot:SECD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SECD_ECOLI eggNOG COG0342 http://eggnogapi.embl.de/nog_data/html/tree/COG0342 eggNOG ENOG4107QN8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QN8 epestfind swissprot:SECD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SECD_ECOLI garnier swissprot:SECD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SECD_ECOLI helixturnhelix swissprot:SECD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SECD_ECOLI hmoment swissprot:SECD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SECD_ECOLI iep swissprot:SECD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SECD_ECOLI inforesidue swissprot:SECD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SECD_ECOLI octanol swissprot:SECD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SECD_ECOLI pepcoil swissprot:SECD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SECD_ECOLI pepdigest swissprot:SECD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SECD_ECOLI pepinfo swissprot:SECD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SECD_ECOLI pepnet swissprot:SECD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SECD_ECOLI pepstats swissprot:SECD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SECD_ECOLI pepwheel swissprot:SECD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SECD_ECOLI pepwindow swissprot:SECD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SECD_ECOLI sigcleave swissprot:SECD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SECD_ECOLI ## Database ID URL or Descriptions # AltName FLGF_ECOLI Putative proximal rod protein # BioGrid 4261897 5 # EcoGene EG14270 flgF # GO_component GO:0009424 bacterial-type flagellum hook; IBA:GO_Central. # GO_component GO:0009425 bacterial-type flagellum basal body; IEA:UniProtKB-SubCell. # GO_process GO:0071973 bacterial-type flagellum-dependent cell motility; IMP:EcoCyc. # GO_process GO:0071978 bacterial-type flagellum-dependent swarming motility; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0048870 cell motility # IntAct P75938 8 # InterPro IPR001444 Flag_bb_rod_N # InterPro IPR010930 Flg_bb/hook_C_dom # InterPro IPR019776 Flagellar_basal_body_rod_CS # InterPro IPR020013 Flagellar_FlgE/F/G # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Pathway ko02040 Flagellar assembly # Organism FLGF_ECOLI Escherichia coli (strain K12) # PATRIC 32117395 VBIEscCol129921_1120 # PIR B64851 B64851 # PROSITE PS00588 FLAGELLA_BB_ROD # Pfam PF00460 Flg_bb_rod # Pfam PF06429 Flg_bbr_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FLGF_ECOLI Flagellar basal-body rod protein FlgF # RefSeq NP_415595 NC_000913.3 # RefSeq WP_000349316 NZ_LN832404.1 # SIMILARITY Belongs to the flagella basal body rod proteins family. {ECO 0000305}. # SUBCELLULAR LOCATION FLGF_ECOLI Bacterial flagellum basal body. # SUBUNIT FLGF_ECOLI The basal body constitutes a major portion of the flagellar organelle and consists of five rings (E,L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each. # TIGRFAMs TIGR03506 FlgEFG_subfam # eggNOG COG4787 LUCA # eggNOG ENOG4108KPB Bacteria BLAST swissprot:FLGF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLGF_ECOLI BioCyc ECOL316407:JW1064-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1064-MONOMER BioCyc EcoCyc:FLGF-FLAGELLAR-MOTOR-ROD-PROTEIN http://biocyc.org/getid?id=EcoCyc:FLGF-FLAGELLAR-MOTOR-ROD-PROTEIN COG COG1749 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1749 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4018 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4018 EcoGene EG14270 http://www.ecogene.org/geneInfo.php?eg_id=EG14270 EnsemblBacteria AAC74161 http://www.ensemblgenomes.org/id/AAC74161 EnsemblBacteria AAC74161 http://www.ensemblgenomes.org/id/AAC74161 EnsemblBacteria BAA35886 http://www.ensemblgenomes.org/id/BAA35886 EnsemblBacteria BAA35886 http://www.ensemblgenomes.org/id/BAA35886 EnsemblBacteria BAA35886 http://www.ensemblgenomes.org/id/BAA35886 EnsemblBacteria b1077 http://www.ensemblgenomes.org/id/b1077 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009424 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009424 GO_component GO:0009425 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009425 GO_process GO:0071973 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071973 GO_process GO:0071978 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071978 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 GeneID 945639 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945639 HOGENOM HOG000254241 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000254241&db=HOGENOM6 InParanoid P75938 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75938 IntAct P75938 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75938* InterPro IPR001444 http://www.ebi.ac.uk/interpro/entry/IPR001444 InterPro IPR010930 http://www.ebi.ac.uk/interpro/entry/IPR010930 InterPro IPR019776 http://www.ebi.ac.uk/interpro/entry/IPR019776 InterPro IPR020013 http://www.ebi.ac.uk/interpro/entry/IPR020013 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW1064 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1064 KEGG_Gene eco:b1077 http://www.genome.jp/dbget-bin/www_bget?eco:b1077 KEGG_Orthology KO:K02391 http://www.genome.jp/dbget-bin/www_bget?KO:K02391 KEGG_Pathway ko02040 http://www.genome.jp/kegg-bin/show_pathway?ko02040 OMA VEPDSNP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VEPDSNP PROSITE PS00588 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00588 PSORT swissprot:FLGF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLGF_ECOLI PSORT-B swissprot:FLGF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLGF_ECOLI PSORT2 swissprot:FLGF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLGF_ECOLI Pfam PF00460 http://pfam.xfam.org/family/PF00460 Pfam PF06429 http://pfam.xfam.org/family/PF06429 Phobius swissprot:FLGF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLGF_ECOLI PhylomeDB P75938 http://phylomedb.org/?seqid=P75938 ProteinModelPortal P75938 http://www.proteinmodelportal.org/query/uniprot/P75938 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415595 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415595 RefSeq WP_000349316 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000349316 SMR P75938 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75938 STRING 511145.b1077 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1077&targetmode=cogs STRING COG1749 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1749&targetmode=cogs TIGRFAMs TIGR03506 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03506 UniProtKB FLGF_ECOLI http://www.uniprot.org/uniprot/FLGF_ECOLI UniProtKB-AC P75938 http://www.uniprot.org/uniprot/P75938 charge swissprot:FLGF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLGF_ECOLI eggNOG COG4787 http://eggnogapi.embl.de/nog_data/html/tree/COG4787 eggNOG ENOG4108KPB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108KPB epestfind swissprot:FLGF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLGF_ECOLI garnier swissprot:FLGF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLGF_ECOLI helixturnhelix swissprot:FLGF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLGF_ECOLI hmoment swissprot:FLGF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLGF_ECOLI iep swissprot:FLGF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLGF_ECOLI inforesidue swissprot:FLGF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLGF_ECOLI octanol swissprot:FLGF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLGF_ECOLI pepcoil swissprot:FLGF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLGF_ECOLI pepdigest swissprot:FLGF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLGF_ECOLI pepinfo swissprot:FLGF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLGF_ECOLI pepnet swissprot:FLGF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLGF_ECOLI pepstats swissprot:FLGF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLGF_ECOLI pepwheel swissprot:FLGF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLGF_ECOLI pepwindow swissprot:FLGF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLGF_ECOLI sigcleave swissprot:FLGF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLGF_ECOLI ## Database ID URL or Descriptions # BioGrid 4262030 13 # EcoGene EG12605 yacL # HAMAP MF_01053 UPF0231 # INTERACTION YACL_ECOLI P0ACJ8 crp; NbExp=3; IntAct=EBI-554965, EBI-547513; # IntAct P0A8E5 55 # InterPro IPR008249 UPF0231 # Organism YACL_ECOLI Escherichia coli (strain K12) # PATRIC 32115339 VBIEscCol129921_0121 # PIR G64734 G64734 # PIRSF PIRSF006287 UCP006287 # Pfam PF06062 UPF0231 # ProDom PD020773 UCP006287 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YACL_ECOLI UPF0231 protein YacL # RefSeq NP_414661 NC_000913.3 # RefSeq WP_000384306 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0231 family. {ECO 0000305}. # eggNOG COG3112 LUCA # eggNOG ENOG4108ZIG Bacteria BLAST swissprot:YACL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YACL_ECOLI BioCyc ECOL316407:JW0115-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0115-MONOMER BioCyc EcoCyc:EG12605-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12605-MONOMER COG COG3112 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3112 DIP DIP-47876N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47876N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J02804 http://www.ebi.ac.uk/ena/data/view/J02804 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2489 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2489 EcoGene EG12605 http://www.ecogene.org/geneInfo.php?eg_id=EG12605 EnsemblBacteria AAC73230 http://www.ensemblgenomes.org/id/AAC73230 EnsemblBacteria AAC73230 http://www.ensemblgenomes.org/id/AAC73230 EnsemblBacteria BAB96693 http://www.ensemblgenomes.org/id/BAB96693 EnsemblBacteria BAB96693 http://www.ensemblgenomes.org/id/BAB96693 EnsemblBacteria BAB96693 http://www.ensemblgenomes.org/id/BAB96693 EnsemblBacteria b0119 http://www.ensemblgenomes.org/id/b0119 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 944809 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944809 HAMAP MF_01053 http://hamap.expasy.org/unirule/MF_01053 HOGENOM HOG000271784 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000271784&db=HOGENOM6 IntAct P0A8E5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8E5* InterPro IPR008249 http://www.ebi.ac.uk/interpro/entry/IPR008249 KEGG_Gene ecj:JW0115 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0115 KEGG_Gene eco:b0119 http://www.genome.jp/dbget-bin/www_bget?eco:b0119 KEGG_Orthology KO:K09910 http://www.genome.jp/dbget-bin/www_bget?KO:K09910 MINT MINT-1220984 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1220984 OMA HEYTLLM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HEYTLLM PSORT swissprot:YACL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YACL_ECOLI PSORT-B swissprot:YACL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YACL_ECOLI PSORT2 swissprot:YACL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YACL_ECOLI Pfam PF06062 http://pfam.xfam.org/family/PF06062 Phobius swissprot:YACL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YACL_ECOLI ProteinModelPortal P0A8E5 http://www.proteinmodelportal.org/query/uniprot/P0A8E5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2666401 http://www.ncbi.nlm.nih.gov/pubmed/2666401 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414661 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414661 RefSeq WP_000384306 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000384306 STRING 511145.b0119 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0119&targetmode=cogs STRING COG3112 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3112&targetmode=cogs UniProtKB YACL_ECOLI http://www.uniprot.org/uniprot/YACL_ECOLI UniProtKB-AC P0A8E5 http://www.uniprot.org/uniprot/P0A8E5 charge swissprot:YACL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YACL_ECOLI eggNOG COG3112 http://eggnogapi.embl.de/nog_data/html/tree/COG3112 eggNOG ENOG4108ZIG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZIG epestfind swissprot:YACL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YACL_ECOLI garnier swissprot:YACL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YACL_ECOLI helixturnhelix swissprot:YACL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YACL_ECOLI hmoment swissprot:YACL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YACL_ECOLI iep swissprot:YACL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YACL_ECOLI inforesidue swissprot:YACL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YACL_ECOLI octanol swissprot:YACL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YACL_ECOLI pepcoil swissprot:YACL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YACL_ECOLI pepdigest swissprot:YACL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YACL_ECOLI pepinfo swissprot:YACL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YACL_ECOLI pepnet swissprot:YACL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YACL_ECOLI pepstats swissprot:YACL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YACL_ECOLI pepwheel swissprot:YACL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YACL_ECOLI pepwindow swissprot:YACL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YACL_ECOLI sigcleave swissprot:YACL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YACL_ECOLI ## Database ID URL or Descriptions # BioGrid 4262157 9 # EcoGene EG12247 yhjC # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0043565 sequence-specific DNA binding; IBA:GO_Central. # GO_process GO:0006351 transcription, DNA-templated; ISS:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # IntAct P37641 2 # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR005119 LysR_subst-bd # InterPro IPR011991 WHTH_DNA-bd_dom # Organism YHJC_ECOLI Escherichia coli (strain K12) # PATRIC 32122504 VBIEscCol129921_3630 # PIR S47741 S47741 # PROSITE PS50931 HTH_LYSR # Pfam PF00126 HTH_1 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHJC_ECOLI Uncharacterized HTH-type transcriptional regulator YhjC # RefSeq NP_417978 NC_000913.3 # RefSeq WP_000357790 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18497.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAE77773.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Contains 1 HTH lysR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00253}. # SUPFAM SSF46785 SSF46785 # eggNOG ENOG4105CBN Bacteria # eggNOG ENOG410XNVB LUCA BLAST swissprot:YHJC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHJC_ECOLI BioCyc ECOL316407:JW3489-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3489-MONOMER BioCyc EcoCyc:EG12247-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12247-MONOMER DIP DIP-12378N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12378N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2158 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2158 EcoGene EG12247 http://www.ecogene.org/geneInfo.php?eg_id=EG12247 EnsemblBacteria AAC76546 http://www.ensemblgenomes.org/id/AAC76546 EnsemblBacteria AAC76546 http://www.ensemblgenomes.org/id/AAC76546 EnsemblBacteria BAE77773 http://www.ensemblgenomes.org/id/BAE77773 EnsemblBacteria BAE77773 http://www.ensemblgenomes.org/id/BAE77773 EnsemblBacteria BAE77773 http://www.ensemblgenomes.org/id/BAE77773 EnsemblBacteria b3521 http://www.ensemblgenomes.org/id/b3521 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 948035 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948035 HOGENOM HOG000233519 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000233519&db=HOGENOM6 InParanoid P37641 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37641 IntAct P37641 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37641* InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW3489 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3489 KEGG_Gene eco:b3521 http://www.genome.jp/dbget-bin/www_bget?eco:b3521 OMA VNFRASH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VNFRASH PROSITE PS50931 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50931 PSORT swissprot:YHJC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHJC_ECOLI PSORT-B swissprot:YHJC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHJC_ECOLI PSORT2 swissprot:YHJC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHJC_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:YHJC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHJC_ECOLI PhylomeDB P37641 http://phylomedb.org/?seqid=P37641 ProteinModelPortal P37641 http://www.proteinmodelportal.org/query/uniprot/P37641 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417978 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417978 RefSeq WP_000357790 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000357790 SMR P37641 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37641 STRING 511145.b3521 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3521&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB YHJC_ECOLI http://www.uniprot.org/uniprot/YHJC_ECOLI UniProtKB-AC P37641 http://www.uniprot.org/uniprot/P37641 charge swissprot:YHJC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHJC_ECOLI eggNOG ENOG4105CBN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CBN eggNOG ENOG410XNVB http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNVB epestfind swissprot:YHJC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHJC_ECOLI garnier swissprot:YHJC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHJC_ECOLI helixturnhelix swissprot:YHJC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHJC_ECOLI hmoment swissprot:YHJC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHJC_ECOLI iep swissprot:YHJC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHJC_ECOLI inforesidue swissprot:YHJC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHJC_ECOLI octanol swissprot:YHJC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHJC_ECOLI pepcoil swissprot:YHJC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHJC_ECOLI pepdigest swissprot:YHJC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHJC_ECOLI pepinfo swissprot:YHJC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHJC_ECOLI pepnet swissprot:YHJC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHJC_ECOLI pepstats swissprot:YHJC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHJC_ECOLI pepwheel swissprot:YHJC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHJC_ECOLI pepwindow swissprot:YHJC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHJC_ECOLI sigcleave swissprot:YHJC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHJC_ECOLI ## Database ID URL or Descriptions # BioGrid 4262203 10 # EcoGene EG11565 fixX # FUNCTION FIXX_ECOLI Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster- containing protein. # GO_function GO:0005506 iron ion binding; IEA:InterPro. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0055114 oxidation-reduction process; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # INTERACTION FIXX_ECOLI P07639 aroB; NbExp=2; IntAct=EBI-1113234, EBI-550843; P0ABH9 clpA; NbExp=2; IntAct=EBI-1113234, EBI-546140; P77806 ybdL; NbExp=3; IntAct=EBI-1113234, EBI-543661; # IntAct P68646 51 # InterPro IPR012206 Fd_FixX # Organism FIXX_ECOLI Escherichia coli (strain K12) # PATRIC 32115187 VBIEscCol129921_0045 # PIR D64725 D64725 # PIRSF PIRSF036548 Fdx_FixX # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FIXX_ECOLI Ferredoxin-like protein FixX # RefSeq NP_414586 NC_000913.3 # RefSeq WP_000203741 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial-type ferredoxin family. FixX subfamily. {ECO 0000305}. # eggNOG COG2440 LUCA # eggNOG ENOG4105IBM Bacteria BLAST swissprot:FIXX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FIXX_ECOLI BioCyc ECOL316407:JW0043-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0043-MONOMER BioCyc EcoCyc:EG11565-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11565-MONOMER COG COG2440 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2440 DOI 10.1002/jobm.3620350404 http://dx.doi.org/10.1002/jobm.3620350404 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.14.4044-4047.2002 http://dx.doi.org/10.1128/JB.184.14.4044-4047.2002 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1526 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1526 EcoGene EG11565 http://www.ecogene.org/geneInfo.php?eg_id=EG11565 EnsemblBacteria AAC73155 http://www.ensemblgenomes.org/id/AAC73155 EnsemblBacteria AAC73155 http://www.ensemblgenomes.org/id/AAC73155 EnsemblBacteria BAB96612 http://www.ensemblgenomes.org/id/BAB96612 EnsemblBacteria BAB96612 http://www.ensemblgenomes.org/id/BAB96612 EnsemblBacteria BAB96612 http://www.ensemblgenomes.org/id/BAB96612 EnsemblBacteria b0044 http://www.ensemblgenomes.org/id/b0044 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0055114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 948590 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948590 HOGENOM HOG000018925 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000018925&db=HOGENOM6 InParanoid P68646 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P68646 IntAct P68646 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P68646* InterPro IPR012206 http://www.ebi.ac.uk/interpro/entry/IPR012206 KEGG_Gene ecj:JW0043 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0043 KEGG_Gene eco:b0044 http://www.genome.jp/dbget-bin/www_bget?eco:b0044 KEGG_Orthology KO:K03855 http://www.genome.jp/dbget-bin/www_bget?KO:K03855 OMA PARCYEL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PARCYEL PSORT swissprot:FIXX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FIXX_ECOLI PSORT-B swissprot:FIXX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FIXX_ECOLI PSORT2 swissprot:FIXX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FIXX_ECOLI Phobius swissprot:FIXX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FIXX_ECOLI PhylomeDB P68646 http://phylomedb.org/?seqid=P68646 ProteinModelPortal P68646 http://www.proteinmodelportal.org/query/uniprot/P68646 PubMed 12081978 http://www.ncbi.nlm.nih.gov/pubmed/12081978 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7473063 http://www.ncbi.nlm.nih.gov/pubmed/7473063 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414586 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414586 RefSeq WP_000203741 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000203741 STRING 511145.b0044 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0044&targetmode=cogs STRING COG2440 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2440&targetmode=cogs UniProtKB FIXX_ECOLI http://www.uniprot.org/uniprot/FIXX_ECOLI UniProtKB-AC P68646 http://www.uniprot.org/uniprot/P68646 charge swissprot:FIXX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FIXX_ECOLI eggNOG COG2440 http://eggnogapi.embl.de/nog_data/html/tree/COG2440 eggNOG ENOG4105IBM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105IBM epestfind swissprot:FIXX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FIXX_ECOLI garnier swissprot:FIXX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FIXX_ECOLI helixturnhelix swissprot:FIXX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FIXX_ECOLI hmoment swissprot:FIXX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FIXX_ECOLI iep swissprot:FIXX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FIXX_ECOLI inforesidue swissprot:FIXX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FIXX_ECOLI octanol swissprot:FIXX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FIXX_ECOLI pepcoil swissprot:FIXX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FIXX_ECOLI pepdigest swissprot:FIXX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FIXX_ECOLI pepinfo swissprot:FIXX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FIXX_ECOLI pepnet swissprot:FIXX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FIXX_ECOLI pepstats swissprot:FIXX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FIXX_ECOLI pepwheel swissprot:FIXX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FIXX_ECOLI pepwindow swissprot:FIXX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FIXX_ECOLI sigcleave swissprot:FIXX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FIXX_ECOLI ## Database ID URL or Descriptions # BioGrid 4262762 6 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG12581 yjiT # IntAct P39391 15 # Organism YJIT_ECOLI Escherichia coli (strain K12) # PATRIC 48668284 VBIEscCol107702_4392 # PIR S56567 S56567 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJIT_ECOLI Putative uncharacterized protein YjiT # RefSeq WP_000964362 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAE78334.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # eggNOG ENOG4108YUH Bacteria # eggNOG ENOG4111M9Y LUCA BLAST swissprot:YJIT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJIT_ECOLI BioCyc ECOL316407:JW5787-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5787-MONOMER BioCyc EcoCyc:G7938-MONOMER http://biocyc.org/getid?id=EcoCyc:G7938-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2468 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2468 EcoGene EG12581 http://www.ecogene.org/geneInfo.php?eg_id=EG12581 EnsemblBacteria BAE78334 http://www.ensemblgenomes.org/id/BAE78334 EnsemblBacteria BAE78334 http://www.ensemblgenomes.org/id/BAE78334 EnsemblBacteria BAE78334 http://www.ensemblgenomes.org/id/BAE78334 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv HOGENOM HOG000202517 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000202517&db=HOGENOM6 IntAct P39391 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39391* KEGG_Gene ecj:JW5787 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5787 OMA IDVTRYT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IDVTRYT PSORT swissprot:YJIT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJIT_ECOLI PSORT-B swissprot:YJIT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJIT_ECOLI PSORT2 swissprot:YJIT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJIT_ECOLI Phobius swissprot:YJIT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJIT_ECOLI ProteinModelPortal P39391 http://www.proteinmodelportal.org/query/uniprot/P39391 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000964362 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000964362 STRING 316407.85677084 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85677084&targetmode=cogs UniProtKB YJIT_ECOLI http://www.uniprot.org/uniprot/YJIT_ECOLI UniProtKB-AC P39391 http://www.uniprot.org/uniprot/P39391 charge swissprot:YJIT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJIT_ECOLI eggNOG ENOG4108YUH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108YUH eggNOG ENOG4111M9Y http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111M9Y epestfind swissprot:YJIT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJIT_ECOLI garnier swissprot:YJIT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJIT_ECOLI helixturnhelix swissprot:YJIT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJIT_ECOLI hmoment swissprot:YJIT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJIT_ECOLI iep swissprot:YJIT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJIT_ECOLI inforesidue swissprot:YJIT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJIT_ECOLI octanol swissprot:YJIT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJIT_ECOLI pepcoil swissprot:YJIT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJIT_ECOLI pepdigest swissprot:YJIT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJIT_ECOLI pepinfo swissprot:YJIT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJIT_ECOLI pepnet swissprot:YJIT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJIT_ECOLI pepstats swissprot:YJIT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJIT_ECOLI pepwheel swissprot:YJIT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJIT_ECOLI pepwindow swissprot:YJIT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJIT_ECOLI sigcleave swissprot:YJIT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJIT_ECOLI ## Database ID URL or Descriptions # BioGrid 4259240 6 # EcoGene EG13289 yqgE # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # HAMAP MF_00758 UPF0301 # IntAct P0A8W5 9 # InterPro IPR003774 UPF0301 # KEGG_Brite ko03000 Transcription factors # Organism YQGE_ECOLI Escherichia coli (strain K12) # PATRIC 32121306 VBIEscCol129921_3041 # Pfam PF02622 DUF179 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQGE_ECOLI UPF0301 protein YqgE # RefSeq NP_417423 NC_000913.3 # RefSeq WP_001053178 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA69115.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the UPF0301 (AlgH) family. {ECO 0000305}. # eggNOG COG1678 LUCA # eggNOG ENOG4108UJU Bacteria BLAST swissprot:YQGE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQGE_ECOLI BioCyc ECOL316407:JW2915-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2915-MONOMER BioCyc EcoCyc:G7524-MONOMER http://biocyc.org/getid?id=EcoCyc:G7524-MONOMER COG COG1678 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1678 DIP DIP-36005N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36005N DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB3074 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3074 EcoGene EG13289 http://www.ecogene.org/geneInfo.php?eg_id=EG13289 EnsemblBacteria AAC75985 http://www.ensemblgenomes.org/id/AAC75985 EnsemblBacteria AAC75985 http://www.ensemblgenomes.org/id/AAC75985 EnsemblBacteria BAE77011 http://www.ensemblgenomes.org/id/BAE77011 EnsemblBacteria BAE77011 http://www.ensemblgenomes.org/id/BAE77011 EnsemblBacteria BAE77011 http://www.ensemblgenomes.org/id/BAE77011 EnsemblBacteria b2948 http://www.ensemblgenomes.org/id/b2948 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GeneID 947442 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947442 HAMAP MF_00758 http://hamap.expasy.org/unirule/MF_00758 HOGENOM HOG000281193 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000281193&db=HOGENOM6 InParanoid P0A8W5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8W5 IntAct P0A8W5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8W5* InterPro IPR003774 http://www.ebi.ac.uk/interpro/entry/IPR003774 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW2915 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2915 KEGG_Gene eco:b2948 http://www.genome.jp/dbget-bin/www_bget?eco:b2948 KEGG_Orthology KO:K07735 http://www.genome.jp/dbget-bin/www_bget?KO:K07735 OMA IYICAHS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IYICAHS PSORT swissprot:YQGE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQGE_ECOLI PSORT-B swissprot:YQGE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQGE_ECOLI PSORT2 swissprot:YQGE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQGE_ECOLI Pfam PF02622 http://pfam.xfam.org/family/PF02622 Phobius swissprot:YQGE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQGE_ECOLI PhylomeDB P0A8W5 http://phylomedb.org/?seqid=P0A8W5 ProteinModelPortal P0A8W5 http://www.proteinmodelportal.org/query/uniprot/P0A8W5 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417423 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417423 RefSeq WP_001053178 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001053178 SMR P0A8W5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8W5 STRING 511145.b2948 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2948&targetmode=cogs STRING COG1678 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1678&targetmode=cogs UniProtKB YQGE_ECOLI http://www.uniprot.org/uniprot/YQGE_ECOLI UniProtKB-AC P0A8W5 http://www.uniprot.org/uniprot/P0A8W5 charge swissprot:YQGE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQGE_ECOLI eggNOG COG1678 http://eggnogapi.embl.de/nog_data/html/tree/COG1678 eggNOG ENOG4108UJU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UJU epestfind swissprot:YQGE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQGE_ECOLI garnier swissprot:YQGE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQGE_ECOLI helixturnhelix swissprot:YQGE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQGE_ECOLI hmoment swissprot:YQGE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQGE_ECOLI iep swissprot:YQGE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQGE_ECOLI inforesidue swissprot:YQGE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQGE_ECOLI octanol swissprot:YQGE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQGE_ECOLI pepcoil swissprot:YQGE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQGE_ECOLI pepdigest swissprot:YQGE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQGE_ECOLI pepinfo swissprot:YQGE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQGE_ECOLI pepnet swissprot:YQGE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQGE_ECOLI pepstats swissprot:YQGE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQGE_ECOLI pepwheel swissprot:YQGE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQGE_ECOLI pepwindow swissprot:YQGE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQGE_ECOLI sigcleave swissprot:YQGE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQGE_ECOLI ## Database ID URL or Descriptions # BioGrid 4260259 13 # EcoGene EG13943 ydhI # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR012451 DUF1656 # Organism YDHI_ECOLI Escherichia coli (strain K12) # PATRIC 32118588 VBIEscCol129921_1714 # PIR E64921 E64921 # Pfam PF07869 DUF1656 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDHI_ECOLI Uncharacterized protein YdhI # RefSeq NP_416160 NC_000913.3 # RefSeq WP_000670998 NZ_CP011343.2 # SUBCELLULAR LOCATION YDHI_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. BLAST swissprot:YDHI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDHI_ECOLI BioCyc ECOL316407:JW1635-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1635-MONOMER BioCyc EcoCyc:G6883-MONOMER http://biocyc.org/getid?id=EcoCyc:G6883-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3701 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3701 EcoGene EG13943 http://www.ecogene.org/geneInfo.php?eg_id=EG13943 EnsemblBacteria AAC74715 http://www.ensemblgenomes.org/id/AAC74715 EnsemblBacteria AAC74715 http://www.ensemblgenomes.org/id/AAC74715 EnsemblBacteria BAE76488 http://www.ensemblgenomes.org/id/BAE76488 EnsemblBacteria BAE76488 http://www.ensemblgenomes.org/id/BAE76488 EnsemblBacteria BAE76488 http://www.ensemblgenomes.org/id/BAE76488 EnsemblBacteria b1643 http://www.ensemblgenomes.org/id/b1643 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 947559 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947559 HOGENOM HOG000283451 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000283451&db=HOGENOM6 InterPro IPR012451 http://www.ebi.ac.uk/interpro/entry/IPR012451 KEGG_Gene ecj:JW1635 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1635 KEGG_Gene eco:b1643 http://www.genome.jp/dbget-bin/www_bget?eco:b1643 OMA DIWHPTL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DIWHPTL PSORT swissprot:YDHI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDHI_ECOLI PSORT-B swissprot:YDHI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDHI_ECOLI PSORT2 swissprot:YDHI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDHI_ECOLI Pfam PF07869 http://pfam.xfam.org/family/PF07869 Phobius swissprot:YDHI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDHI_ECOLI ProteinModelPortal P64471 http://www.proteinmodelportal.org/query/uniprot/P64471 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416160 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416160 RefSeq WP_000670998 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000670998 STRING 511145.b1643 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1643&targetmode=cogs UniProtKB YDHI_ECOLI http://www.uniprot.org/uniprot/YDHI_ECOLI UniProtKB-AC P64471 http://www.uniprot.org/uniprot/P64471 charge swissprot:YDHI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDHI_ECOLI epestfind swissprot:YDHI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDHI_ECOLI garnier swissprot:YDHI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDHI_ECOLI helixturnhelix swissprot:YDHI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDHI_ECOLI hmoment swissprot:YDHI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDHI_ECOLI iep swissprot:YDHI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDHI_ECOLI inforesidue swissprot:YDHI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDHI_ECOLI octanol swissprot:YDHI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDHI_ECOLI pepcoil swissprot:YDHI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDHI_ECOLI pepdigest swissprot:YDHI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDHI_ECOLI pepinfo swissprot:YDHI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDHI_ECOLI pepnet swissprot:YDHI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDHI_ECOLI pepstats swissprot:YDHI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDHI_ECOLI pepwheel swissprot:YDHI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDHI_ECOLI pepwindow swissprot:YDHI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDHI_ECOLI sigcleave swissprot:YDHI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDHI_ECOLI ## Database ID URL or Descriptions # BioGrid 4259853 2 # EcoGene EG13261 ybbN # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0015035 protein disulfide oxidoreductase activity; IDA:EcoCyc. # GO_function GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor; IBA:GO_Central. # GO_process GO:0000103 sulfate assimilation; IBA:GO_Central. # GO_process GO:0006662 glycerol ether metabolic process; IEA:InterPro. # GO_process GO:0034599 cellular response to oxidative stress; IBA:GO_Central. # GO_process GO:0045454 cell redox homeostasis; IBA:GO_Central. # GO_process GO:0061077 chaperone-mediated protein folding; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006457 protein folding # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0042592 homeostatic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.25.40.10 -; 2. # Gene3D 3.40.30.10 -; 1. # IntAct P77395 7 # InterPro IPR005746 Thioredoxin # InterPro IPR011990 TPR-like_helical_dom # InterPro IPR012336 Thioredoxin-like_fold # InterPro IPR013766 Thioredoxin_domain # KEGG_Brite ko03110 Chaperones and folding catalysts # Organism YBBN_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10438 PTHR10438 # PATRIC 32116143 VBIEscCol129921_0513 # PDB 3QOU X-ray; 1.80 A; A=1-284 # PIR C64780 C64780 # PROSITE PS51352 THIOREDOXIN_2 # Pfam PF00085 Thioredoxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBBN_ECOLI Uncharacterized protein YbbN # RefSeq NP_415025 NC_000913.3 # RefSeq WP_001300573 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40246.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Contains 1 thioredoxin domain. {ECO:0000255|PROSITE- ProRule PRU00691}. # SUPFAM SSF48452 SSF48452 # SUPFAM SSF52833 SSF52833 # eggNOG COG3118 LUCA # eggNOG ENOG4107QR8 Bacteria BLAST swissprot:YBBN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBBN_ECOLI BioCyc ECOL316407:JW5067-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5067-MONOMER BioCyc EcoCyc:G6268-MONOMER http://biocyc.org/getid?id=EcoCyc:G6268-MONOMER COG COG3118 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3118 DIP DIP-11322N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11322N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EchoBASE EB3049 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3049 EcoGene EG13261 http://www.ecogene.org/geneInfo.php?eg_id=EG13261 EnsemblBacteria AAC73594 http://www.ensemblgenomes.org/id/AAC73594 EnsemblBacteria AAC73594 http://www.ensemblgenomes.org/id/AAC73594 EnsemblBacteria BAE76271 http://www.ensemblgenomes.org/id/BAE76271 EnsemblBacteria BAE76271 http://www.ensemblgenomes.org/id/BAE76271 EnsemblBacteria BAE76271 http://www.ensemblgenomes.org/id/BAE76271 EnsemblBacteria b0492 http://www.ensemblgenomes.org/id/b0492 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0015035 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015035 GO_function GO:0016671 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016671 GO_process GO:0000103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000103 GO_process GO:0006662 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006662 GO_process GO:0034599 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034599 GO_process GO:0045454 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045454 GO_process GO:0061077 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061077 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.25.40.10 http://www.cathdb.info/version/latest/superfamily/1.25.40.10 Gene3D 3.40.30.10 http://www.cathdb.info/version/latest/superfamily/3.40.30.10 GeneID 947119 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947119 HOGENOM HOG000247095 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000247095&db=HOGENOM6 InParanoid P77395 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77395 IntAct P77395 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77395* InterPro IPR005746 http://www.ebi.ac.uk/interpro/entry/IPR005746 InterPro IPR011990 http://www.ebi.ac.uk/interpro/entry/IPR011990 InterPro IPR012336 http://www.ebi.ac.uk/interpro/entry/IPR012336 InterPro IPR013766 http://www.ebi.ac.uk/interpro/entry/IPR013766 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW5067 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5067 KEGG_Gene eco:b0492 http://www.genome.jp/dbget-bin/www_bget?eco:b0492 KEGG_Orthology KO:K05838 http://www.genome.jp/dbget-bin/www_bget?KO:K05838 MINT MINT-1222054 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1222054 OMA HVIAFAD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HVIAFAD PANTHER PTHR10438 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10438 PDB 3QOU http://www.ebi.ac.uk/pdbe-srv/view/entry/3QOU PDBsum 3QOU http://www.ebi.ac.uk/pdbsum/3QOU PROSITE PS51352 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51352 PSORT swissprot:YBBN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBBN_ECOLI PSORT-B swissprot:YBBN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBBN_ECOLI PSORT2 swissprot:YBBN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBBN_ECOLI Pfam PF00085 http://pfam.xfam.org/family/PF00085 Phobius swissprot:YBBN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBBN_ECOLI PhylomeDB P77395 http://phylomedb.org/?seqid=P77395 ProteinModelPortal P77395 http://www.proteinmodelportal.org/query/uniprot/P77395 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415025 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415025 RefSeq WP_001300573 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300573 SMR P77395 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77395 STRING 511145.b0492 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0492&targetmode=cogs STRING COG3118 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3118&targetmode=cogs SUPFAM SSF48452 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48452 SUPFAM SSF52833 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52833 SWISS-2DPAGE P77395 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P77395 UniProtKB YBBN_ECOLI http://www.uniprot.org/uniprot/YBBN_ECOLI UniProtKB-AC P77395 http://www.uniprot.org/uniprot/P77395 charge swissprot:YBBN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBBN_ECOLI eggNOG COG3118 http://eggnogapi.embl.de/nog_data/html/tree/COG3118 eggNOG ENOG4107QR8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QR8 epestfind swissprot:YBBN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBBN_ECOLI garnier swissprot:YBBN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBBN_ECOLI helixturnhelix swissprot:YBBN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBBN_ECOLI hmoment swissprot:YBBN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBBN_ECOLI iep swissprot:YBBN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBBN_ECOLI inforesidue swissprot:YBBN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBBN_ECOLI octanol swissprot:YBBN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBBN_ECOLI pepcoil swissprot:YBBN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBBN_ECOLI pepdigest swissprot:YBBN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBBN_ECOLI pepinfo swissprot:YBBN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBBN_ECOLI pepnet swissprot:YBBN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBBN_ECOLI pepstats swissprot:YBBN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBBN_ECOLI pepwheel swissprot:YBBN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBBN_ECOLI pepwindow swissprot:YBBN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBBN_ECOLI sigcleave swissprot:YBBN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBBN_ECOLI ## Database ID URL or Descriptions # BRENDA 2.4.2 2026 # BioGrid 4263299 4 # CATALYTIC ACTIVITY UDP_ECOLI Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate. # EcoGene EG11045 udp # FUNCTION UDP_ECOLI Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0004850 uridine phosphorylase activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0009166 nucleotide catabolic process; IEA:InterPro. # GO_process GO:0044206 UMP salvage; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.1580 -; 1. # IntAct P12758 4 # InterPro IPR000845 Nucleoside_phosphorylase_d # InterPro IPR010058 Uridine_phosphorylase # InterPro IPR018016 Nucleoside_phosphorylase_CS # InterPro IPR018017 Nucleoside_phosphorylase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00240 Pyrimidine metabolism # KEGG_Pathway ko00983 Drug metabolism - other enzymes # Organism UDP_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21234 PTHR21234 # PATHWAY Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route) step 1/1. # PATRIC 32123163 VBIEscCol129921_3947 # PDB 1K3F X-ray; 2.50 A; A/B/C/D/E/F=1-253 # PDB 1LX7 X-ray; 2.00 A; A/B=1-253 # PDB 1RXC X-ray; 2.35 A; A/B/C/D/E/F/G/H/I/J/K/L=1-253 # PDB 1RXS X-ray; 2.80 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/a/b/c/d/e/h/i/j/k/l/m/o=1-253 # PDB 1RXU X-ray; 3.10 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R=1-253 # PDB 1RXY X-ray; 1.70 A; A/B=1-253 # PDB 1T0U X-ray; 2.20 A; A/B=1-253 # PDB 1TGV X-ray; 2.20 A; A/B=1-253 # PDB 1TGY X-ray; 2.20 A; A/B=1-253 # PDB 1U1C X-ray; 2.20 A; A/B/C/D/E/F=2-253 # PDB 1U1D X-ray; 2.00 A; A/B/C/D/E/F=2-253 # PDB 1U1E X-ray; 2.00 A; A/B/C/D/E/F=2-253 # PDB 1U1F X-ray; 2.30 A; A/B/C/D/E/F=2-253 # PDB 1U1G X-ray; 1.95 A; A/B/C/D/E/F=2-253 # PDB 3KVV X-ray; 1.80 A; A/B/C/D/E/F=1-253 # PIR S05491 S05491 # PROSITE PS01232 PNP_UDP_1 # Pfam PF01048 PNP_UDP_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UDP_ECOLI Uridine phosphorylase # RefSeq NP_418275 NC_000913.3 # RefSeq WP_000045177 NZ_LN832404.1 # SIMILARITY Belongs to the PNP/UDP phosphorylase family. {ECO 0000305}. # SUBCELLULAR LOCATION UDP_ECOLI Cytoplasm. # SUBUNIT UDP_ECOLI Homohexamer. The homohexamer shows 4-fold, 6-fold or 8- fold symmetry. # SUPFAM SSF53167 SSF53167 # TIGRFAMs TIGR01718 Uridine-psphlse # UniPathway UPA00574 UER00633 # eggNOG COG2820 LUCA # eggNOG ENOG4108I5U Bacteria BLAST swissprot:UDP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UDP_ECOLI BioCyc ECOL316407:JW3808-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3808-MONOMER BioCyc EcoCyc:URPHOS-MONOMER http://biocyc.org/getid?id=EcoCyc:URPHOS-MONOMER BioCyc MetaCyc:URPHOS-MONOMER http://biocyc.org/getid?id=MetaCyc:URPHOS-MONOMER COG COG2820 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2820 DIP DIP-11075N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11075N DOI 10.1016/0014-5793(95)00489-V http://dx.doi.org/10.1016/0014-5793(95)00489-V DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.90.11.5011 http://dx.doi.org/10.1073/pnas.90.11.5011 DOI 10.1093/nar/17.16.6741 http://dx.doi.org/10.1093/nar/17.16.6741 DOI 10.1111/j.1365-2958.1996.tb02652.x http://dx.doi.org/10.1111/j.1365-2958.1996.tb02652.x DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.4.2.3 http://www.genome.jp/dbget-bin/www_bget?EC:2.4.2.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X15689 http://www.ebi.ac.uk/ena/data/view/X15689 ENZYME 2.4.2.3 http://enzyme.expasy.org/EC/2.4.2.3 EchoBASE EB1038 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1038 EcoGene EG11045 http://www.ecogene.org/geneInfo.php?eg_id=EG11045 EnsemblBacteria AAC76834 http://www.ensemblgenomes.org/id/AAC76834 EnsemblBacteria AAC76834 http://www.ensemblgenomes.org/id/AAC76834 EnsemblBacteria BAE77470 http://www.ensemblgenomes.org/id/BAE77470 EnsemblBacteria BAE77470 http://www.ensemblgenomes.org/id/BAE77470 EnsemblBacteria BAE77470 http://www.ensemblgenomes.org/id/BAE77470 EnsemblBacteria b3831 http://www.ensemblgenomes.org/id/b3831 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0004850 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004850 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0009166 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009166 GO_process GO:0044206 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044206 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.1580 http://www.cathdb.info/version/latest/superfamily/3.40.50.1580 GeneID 948987 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948987 HOGENOM HOG000274897 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000274897&db=HOGENOM6 InParanoid P12758 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P12758 IntAct P12758 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P12758* IntEnz 2.4.2.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.2.3 InterPro IPR000845 http://www.ebi.ac.uk/interpro/entry/IPR000845 InterPro IPR010058 http://www.ebi.ac.uk/interpro/entry/IPR010058 InterPro IPR018016 http://www.ebi.ac.uk/interpro/entry/IPR018016 InterPro IPR018017 http://www.ebi.ac.uk/interpro/entry/IPR018017 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3808 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3808 KEGG_Gene eco:b3831 http://www.genome.jp/dbget-bin/www_bget?eco:b3831 KEGG_Orthology KO:K00757 http://www.genome.jp/dbget-bin/www_bget?KO:K00757 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Pathway ko00983 http://www.genome.jp/kegg-bin/show_pathway?ko00983 KEGG_Reaction rn:R01876 http://www.genome.jp/dbget-bin/www_bget?rn:R01876 KEGG_Reaction rn:R08229 http://www.genome.jp/dbget-bin/www_bget?rn:R08229 MINT MINT-6478293 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-6478293 OMA PHIGITA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PHIGITA PANTHER PTHR21234 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21234 PDB 1K3F http://www.ebi.ac.uk/pdbe-srv/view/entry/1K3F PDB 1LX7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1LX7 PDB 1RXC http://www.ebi.ac.uk/pdbe-srv/view/entry/1RXC PDB 1RXS http://www.ebi.ac.uk/pdbe-srv/view/entry/1RXS PDB 1RXU http://www.ebi.ac.uk/pdbe-srv/view/entry/1RXU PDB 1RXY http://www.ebi.ac.uk/pdbe-srv/view/entry/1RXY PDB 1T0U http://www.ebi.ac.uk/pdbe-srv/view/entry/1T0U PDB 1TGV http://www.ebi.ac.uk/pdbe-srv/view/entry/1TGV PDB 1TGY http://www.ebi.ac.uk/pdbe-srv/view/entry/1TGY PDB 1U1C http://www.ebi.ac.uk/pdbe-srv/view/entry/1U1C PDB 1U1D http://www.ebi.ac.uk/pdbe-srv/view/entry/1U1D PDB 1U1E http://www.ebi.ac.uk/pdbe-srv/view/entry/1U1E PDB 1U1F http://www.ebi.ac.uk/pdbe-srv/view/entry/1U1F PDB 1U1G http://www.ebi.ac.uk/pdbe-srv/view/entry/1U1G PDB 3KVV http://www.ebi.ac.uk/pdbe-srv/view/entry/3KVV PDBsum 1K3F http://www.ebi.ac.uk/pdbsum/1K3F PDBsum 1LX7 http://www.ebi.ac.uk/pdbsum/1LX7 PDBsum 1RXC http://www.ebi.ac.uk/pdbsum/1RXC PDBsum 1RXS http://www.ebi.ac.uk/pdbsum/1RXS PDBsum 1RXU http://www.ebi.ac.uk/pdbsum/1RXU PDBsum 1RXY http://www.ebi.ac.uk/pdbsum/1RXY PDBsum 1T0U http://www.ebi.ac.uk/pdbsum/1T0U PDBsum 1TGV http://www.ebi.ac.uk/pdbsum/1TGV PDBsum 1TGY http://www.ebi.ac.uk/pdbsum/1TGY PDBsum 1U1C http://www.ebi.ac.uk/pdbsum/1U1C PDBsum 1U1D http://www.ebi.ac.uk/pdbsum/1U1D PDBsum 1U1E http://www.ebi.ac.uk/pdbsum/1U1E PDBsum 1U1F http://www.ebi.ac.uk/pdbsum/1U1F PDBsum 1U1G http://www.ebi.ac.uk/pdbsum/1U1G PDBsum 3KVV http://www.ebi.ac.uk/pdbsum/3KVV PROSITE PS01232 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01232 PSORT swissprot:UDP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UDP_ECOLI PSORT-B swissprot:UDP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UDP_ECOLI PSORT2 swissprot:UDP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UDP_ECOLI Pfam PF01048 http://pfam.xfam.org/family/PF01048 Phobius swissprot:UDP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UDP_ECOLI PhylomeDB P12758 http://phylomedb.org/?seqid=P12758 ProteinModelPortal P12758 http://www.proteinmodelportal.org/query/uniprot/P12758 PubMed 12499542 http://www.ncbi.nlm.nih.gov/pubmed/12499542 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2674901 http://www.ncbi.nlm.nih.gov/pubmed/2674901 PubMed 7796917 http://www.ncbi.nlm.nih.gov/pubmed/7796917 PubMed 8506346 http://www.ncbi.nlm.nih.gov/pubmed/8506346 PubMed 8899705 http://www.ncbi.nlm.nih.gov/pubmed/8899705 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9661793 http://www.ncbi.nlm.nih.gov/pubmed/9661793 RefSeq NP_418275 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418275 RefSeq WP_000045177 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000045177 SMR P12758 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P12758 STRING 511145.b3831 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3831&targetmode=cogs STRING COG2820 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2820&targetmode=cogs SUPFAM SSF53167 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53167 SWISS-2DPAGE P12758 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P12758 TIGRFAMs TIGR01718 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01718 UniProtKB UDP_ECOLI http://www.uniprot.org/uniprot/UDP_ECOLI UniProtKB-AC P12758 http://www.uniprot.org/uniprot/P12758 charge swissprot:UDP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UDP_ECOLI eggNOG COG2820 http://eggnogapi.embl.de/nog_data/html/tree/COG2820 eggNOG ENOG4108I5U http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108I5U epestfind swissprot:UDP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UDP_ECOLI garnier swissprot:UDP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UDP_ECOLI helixturnhelix swissprot:UDP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UDP_ECOLI hmoment swissprot:UDP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UDP_ECOLI iep swissprot:UDP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UDP_ECOLI inforesidue swissprot:UDP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UDP_ECOLI octanol swissprot:UDP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UDP_ECOLI pepcoil swissprot:UDP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UDP_ECOLI pepdigest swissprot:UDP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UDP_ECOLI pepinfo swissprot:UDP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UDP_ECOLI pepnet swissprot:UDP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UDP_ECOLI pepstats swissprot:UDP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UDP_ECOLI pepwheel swissprot:UDP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UDP_ECOLI pepwindow swissprot:UDP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UDP_ECOLI sigcleave swissprot:UDP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UDP_ECOLI ## Database ID URL or Descriptions # BioGrid 4260667 12 # EcoGene EG20276 mhpR # FUNCTION MHPR_ECOLI Activator of the mhpABCDFE operon coding for components of the 3-hydroxyphenylpropionate degradation pathway. {ECO 0000269|PubMed 9098055}. # GO_function GO:0003677 DNA binding; IBA:GO_Central. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IBA:GO_Central. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0019439 aromatic compound catabolic process; IEA:UniProtKB-KW. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IBA:GO_Central. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # Gene3D 3.30.450.40 -; 1. # IntAct P77569 4 # InterPro IPR005471 Tscrpt_reg_IclR_N # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR014757 Tscrpt_reg_IclR_C # InterPro IPR029016 GAF_dom-like # KEGG_Brite ko03000 Transcription factors # Organism MHPR_ECOLI Escherichia coli (strain K12) # PATRIC 32115825 VBIEscCol129921_0354 # PIR B64762 B64762 # PROSITE PS51077 HTH_ICLR # PROSITE PS51078 ICLR_ED # Pfam PF01614 IclR # Pfam PF09339 HTH_IclR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MHPR_ECOLI Mhp operon transcriptional activator # RefSeq NP_414880 NC_000913.3 # RefSeq WP_001301325 NZ_LN832404.1 # SEQUENCE CAUTION MHPR_ECOLI Sequence=AAB18070.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=BAA13051.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=BAE76128.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=CAA70746.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Contains 1 HTH iclR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00393}. # SIMILARITY Contains 1 iclR-ED (iclR effector binding) domain. {ECO:0000255|PROSITE-ProRule PRU00394}. # SMART SM00346 HTH_ICLR # SUPFAM SSF46785 SSF46785 # SUPFAM SSF55781 SSF55781 # eggNOG COG1414 LUCA # eggNOG ENOG4108K2P Bacteria BLAST swissprot:MHPR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MHPR_ECOLI BioCyc ECOL316407:JW0337-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0337-MONOMER BioCyc EcoCyc:G6201-MONOMER http://biocyc.org/getid?id=EcoCyc:G6201-MONOMER COG COG1414 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1414 DIP DIP-10211N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10211N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D86239 http://www.ebi.ac.uk/ena/data/view/D86239 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EMBL Y09555 http://www.ebi.ac.uk/ena/data/view/Y09555 EchoBASE EB4169 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4169 EcoGene EG20276 http://www.ecogene.org/geneInfo.php?eg_id=EG20276 EnsemblBacteria AAC73449 http://www.ensemblgenomes.org/id/AAC73449 EnsemblBacteria AAC73449 http://www.ensemblgenomes.org/id/AAC73449 EnsemblBacteria BAE76128 http://www.ensemblgenomes.org/id/BAE76128 EnsemblBacteria BAE76128 http://www.ensemblgenomes.org/id/BAE76128 EnsemblBacteria BAE76128 http://www.ensemblgenomes.org/id/BAE76128 EnsemblBacteria b0346 http://www.ensemblgenomes.org/id/b0346 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0019439 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019439 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 3.30.450.40 http://www.cathdb.info/version/latest/superfamily/3.30.450.40 GeneID 945938 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945938 HOGENOM HOG000230079 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230079&db=HOGENOM6 InParanoid P77569 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77569 IntAct P77569 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77569* InterPro IPR005471 http://www.ebi.ac.uk/interpro/entry/IPR005471 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR014757 http://www.ebi.ac.uk/interpro/entry/IPR014757 InterPro IPR029016 http://www.ebi.ac.uk/interpro/entry/IPR029016 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW0337 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0337 KEGG_Gene eco:b0346 http://www.genome.jp/dbget-bin/www_bget?eco:b0346 KEGG_Orthology KO:K05818 http://www.genome.jp/dbget-bin/www_bget?KO:K05818 OMA IIRETTH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IIRETTH PROSITE PS51077 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51077 PROSITE PS51078 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51078 PSORT swissprot:MHPR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MHPR_ECOLI PSORT-B swissprot:MHPR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MHPR_ECOLI PSORT2 swissprot:MHPR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MHPR_ECOLI Pfam PF01614 http://pfam.xfam.org/family/PF01614 Pfam PF09339 http://pfam.xfam.org/family/PF09339 Phobius swissprot:MHPR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MHPR_ECOLI PhylomeDB P77569 http://phylomedb.org/?seqid=P77569 ProteinModelPortal P77569 http://www.proteinmodelportal.org/query/uniprot/P77569 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9098055 http://www.ncbi.nlm.nih.gov/pubmed/9098055 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414880 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414880 RefSeq WP_001301325 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001301325 SMART SM00346 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00346 SMR P77569 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77569 STRING 511145.b0346 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0346&targetmode=cogs STRING COG1414 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1414&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SUPFAM SSF55781 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55781 UniProtKB MHPR_ECOLI http://www.uniprot.org/uniprot/MHPR_ECOLI UniProtKB-AC P77569 http://www.uniprot.org/uniprot/P77569 charge swissprot:MHPR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MHPR_ECOLI eggNOG COG1414 http://eggnogapi.embl.de/nog_data/html/tree/COG1414 eggNOG ENOG4108K2P http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108K2P epestfind swissprot:MHPR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MHPR_ECOLI garnier swissprot:MHPR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MHPR_ECOLI helixturnhelix swissprot:MHPR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MHPR_ECOLI hmoment swissprot:MHPR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MHPR_ECOLI iep swissprot:MHPR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MHPR_ECOLI inforesidue swissprot:MHPR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MHPR_ECOLI octanol swissprot:MHPR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MHPR_ECOLI pepcoil swissprot:MHPR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MHPR_ECOLI pepdigest swissprot:MHPR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MHPR_ECOLI pepinfo swissprot:MHPR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MHPR_ECOLI pepnet swissprot:MHPR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MHPR_ECOLI pepstats swissprot:MHPR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MHPR_ECOLI pepwheel swissprot:MHPR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MHPR_ECOLI pepwindow swissprot:MHPR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MHPR_ECOLI sigcleave swissprot:MHPR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MHPR_ECOLI ## Database ID URL or Descriptions # BioGrid 4261274 41 # EcoGene EG14332 ykfH # InterPro IPR009329 DUF987 # Organism YKFH_ECOLI Escherichia coli (strain K12) # PATRIC 32115609 VBIEscCol129921_0248 # Pfam PF06174 DUF987 # ProDom PD056719 DUF987 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YKFH_ECOLI Uncharacterized protein YkfH # RefSeq YP_588435 NC_000913.3 # SIMILARITY Belongs to the YeeT/YkfH/YpjJ family. {ECO 0000305}. # eggNOG ENOG4105ZS6 Bacteria # eggNOG ENOG4112BCS LUCA BLAST swissprot:YKFH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YKFH_ECOLI BioCyc ECOL316407:JW5956-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5956-MONOMER BioCyc EcoCyc:MONOMER0-2654 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2654 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14332 http://www.ecogene.org/geneInfo.php?eg_id=EG14332 EnsemblBacteria ABD18634 http://www.ensemblgenomes.org/id/ABD18634 EnsemblBacteria ABD18634 http://www.ensemblgenomes.org/id/ABD18634 EnsemblBacteria BAA77915 http://www.ensemblgenomes.org/id/BAA77915 EnsemblBacteria BAA77915 http://www.ensemblgenomes.org/id/BAA77915 EnsemblBacteria BAA77915 http://www.ensemblgenomes.org/id/BAA77915 EnsemblBacteria b4504 http://www.ensemblgenomes.org/id/b4504 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1450236 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1450236 HOGENOM HOG000267802 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267802&db=HOGENOM6 InterPro IPR009329 http://www.ebi.ac.uk/interpro/entry/IPR009329 KEGG_Gene ecj:JW5956 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5956 KEGG_Gene eco:b4504 http://www.genome.jp/dbget-bin/www_bget?eco:b4504 OMA RNGPYAC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RNGPYAC PSORT swissprot:YKFH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YKFH_ECOLI PSORT-B swissprot:YKFH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YKFH_ECOLI PSORT2 swissprot:YKFH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YKFH_ECOLI Pfam PF06174 http://pfam.xfam.org/family/PF06174 Phobius swissprot:YKFH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YKFH_ECOLI PhylomeDB Q9XB42 http://phylomedb.org/?seqid=Q9XB42 ProteinModelPortal Q9XB42 http://www.proteinmodelportal.org/query/uniprot/Q9XB42 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq YP_588435 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_588435 STRING 511145.b4504 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4504&targetmode=cogs UniProtKB YKFH_ECOLI http://www.uniprot.org/uniprot/YKFH_ECOLI UniProtKB-AC Q9XB42 http://www.uniprot.org/uniprot/Q9XB42 charge swissprot:YKFH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YKFH_ECOLI eggNOG ENOG4105ZS6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ZS6 eggNOG ENOG4112BCS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4112BCS epestfind swissprot:YKFH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YKFH_ECOLI garnier swissprot:YKFH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YKFH_ECOLI helixturnhelix swissprot:YKFH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YKFH_ECOLI hmoment swissprot:YKFH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YKFH_ECOLI iep swissprot:YKFH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YKFH_ECOLI inforesidue swissprot:YKFH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YKFH_ECOLI octanol swissprot:YKFH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YKFH_ECOLI pepcoil swissprot:YKFH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YKFH_ECOLI pepdigest swissprot:YKFH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YKFH_ECOLI pepinfo swissprot:YKFH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YKFH_ECOLI pepnet swissprot:YKFH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YKFH_ECOLI pepstats swissprot:YKFH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YKFH_ECOLI pepwheel swissprot:YKFH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YKFH_ECOLI pepwindow swissprot:YKFH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YKFH_ECOLI sigcleave swissprot:YKFH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YKFH_ECOLI ## Database ID URL or Descriptions # BioGrid 4259549 206 # EcoGene EG14144 yfdV # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0055085 transmembrane transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0055085 transmembrane transport # InterPro IPR004776 Mem_trans # Organism YFDV_ECOLI Escherichia coli (strain K12) # PATRIC 32120123 VBIEscCol129921_2470 # PIR A65011 A65011 # Pfam PF03547 Mem_trans; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFDV_ECOLI Uncharacterized transporter YfdV # RefSeq NP_416873 NC_000913.3 # RefSeq WP_000955028 NZ_LN832404.1 # SIMILARITY Belongs to the auxin efflux carrier (TC 2.A.69) family. {ECO 0000305}. # SUBCELLULAR LOCATION YFDV_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # eggNOG COG0679 LUCA # eggNOG ENOG4108N2Y Bacteria BLAST swissprot:YFDV_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFDV_ECOLI BioCyc ECOL316407:JW2369-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2369-MONOMER BioCyc EcoCyc:B2372-MONOMER http://biocyc.org/getid?id=EcoCyc:B2372-MONOMER COG COG0679 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0679 DIP DIP-28062N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-28062N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3896 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3896 EcoGene EG14144 http://www.ecogene.org/geneInfo.php?eg_id=EG14144 EnsemblBacteria AAC75431 http://www.ensemblgenomes.org/id/AAC75431 EnsemblBacteria AAC75431 http://www.ensemblgenomes.org/id/AAC75431 EnsemblBacteria BAA16243 http://www.ensemblgenomes.org/id/BAA16243 EnsemblBacteria BAA16243 http://www.ensemblgenomes.org/id/BAA16243 EnsemblBacteria BAA16243 http://www.ensemblgenomes.org/id/BAA16243 EnsemblBacteria b2372 http://www.ensemblgenomes.org/id/b2372 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 949110 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949110 HOGENOM HOG000122890 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122890&db=HOGENOM6 InParanoid P0AA49 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AA49 IntAct P0AA49 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AA49* InterPro IPR004776 http://www.ebi.ac.uk/interpro/entry/IPR004776 KEGG_Gene ecj:JW2369 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2369 KEGG_Gene eco:b2372 http://www.genome.jp/dbget-bin/www_bget?eco:b2372 KEGG_Orthology KO:K07088 http://www.genome.jp/dbget-bin/www_bget?KO:K07088 OMA FKKSPQD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FKKSPQD PSORT swissprot:YFDV_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFDV_ECOLI PSORT-B swissprot:YFDV_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFDV_ECOLI PSORT2 swissprot:YFDV_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFDV_ECOLI Pfam PF03547 http://pfam.xfam.org/family/PF03547 Phobius swissprot:YFDV_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFDV_ECOLI PhylomeDB P0AA49 http://phylomedb.org/?seqid=P0AA49 ProteinModelPortal P0AA49 http://www.proteinmodelportal.org/query/uniprot/P0AA49 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416873 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416873 RefSeq WP_000955028 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000955028 STRING 511145.b2372 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2372&targetmode=cogs STRING COG0679 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0679&targetmode=cogs UniProtKB YFDV_ECOLI http://www.uniprot.org/uniprot/YFDV_ECOLI UniProtKB-AC P0AA49 http://www.uniprot.org/uniprot/P0AA49 charge swissprot:YFDV_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFDV_ECOLI eggNOG COG0679 http://eggnogapi.embl.de/nog_data/html/tree/COG0679 eggNOG ENOG4108N2Y http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108N2Y epestfind swissprot:YFDV_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFDV_ECOLI garnier swissprot:YFDV_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFDV_ECOLI helixturnhelix swissprot:YFDV_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFDV_ECOLI hmoment swissprot:YFDV_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFDV_ECOLI iep swissprot:YFDV_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFDV_ECOLI inforesidue swissprot:YFDV_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFDV_ECOLI octanol swissprot:YFDV_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFDV_ECOLI pepcoil swissprot:YFDV_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFDV_ECOLI pepdigest swissprot:YFDV_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFDV_ECOLI pepinfo swissprot:YFDV_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFDV_ECOLI pepnet swissprot:YFDV_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFDV_ECOLI pepstats swissprot:YFDV_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFDV_ECOLI pepwheel swissprot:YFDV_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFDV_ECOLI pepwindow swissprot:YFDV_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFDV_ECOLI sigcleave swissprot:YFDV_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFDV_ECOLI ## Database ID URL or Descriptions # BioGrid 4262155 14 # EcoGene EG12251 yhjG # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0090313 regulation of protein targeting to membrane; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0008150 biological_process # IntAct P37645 2 # InterPro IPR007844 AsmA # Organism YHJG_ECOLI Escherichia coli (strain K12) # PATRIC 32122510 VBIEscCol129921_3633 # PIR G65150 G65150 # Pfam PF05170 AsmA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHJG_ECOLI Uncharacterized protein YhjG # RefSeq NP_417981 NC_000913.3 # RefSeq WP_001296794 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18501.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAB18501.1; Type=Frameshift; Positions=155, 673; Evidence={ECO 0000305}; Sequence=BAE77770.1; Type=Erroneous initiation; Evidence={ECO:0000305}; # SUBCELLULAR LOCATION YHJG_ECOLI Cell membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. # TCDB 9.B.121.1 the asma (asma) family # eggNOG COG2982 LUCA # eggNOG ENOG41066T0 Bacteria BLAST swissprot:YHJG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHJG_ECOLI BioCyc ECOL316407:JW3492-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3492-MONOMER BioCyc EcoCyc:EG12251-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12251-MONOMER COG COG2982 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2982 DIP DIP-12381N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12381N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2161 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2161 EcoGene EG12251 http://www.ecogene.org/geneInfo.php?eg_id=EG12251 EnsemblBacteria AAC76549 http://www.ensemblgenomes.org/id/AAC76549 EnsemblBacteria AAC76549 http://www.ensemblgenomes.org/id/AAC76549 EnsemblBacteria BAE77770 http://www.ensemblgenomes.org/id/BAE77770 EnsemblBacteria BAE77770 http://www.ensemblgenomes.org/id/BAE77770 EnsemblBacteria BAE77770 http://www.ensemblgenomes.org/id/BAE77770 EnsemblBacteria b3524 http://www.ensemblgenomes.org/id/b3524 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0090313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090313 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 948043 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948043 HOGENOM HOG000260819 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260819&db=HOGENOM6 InParanoid P37645 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37645 IntAct P37645 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37645* InterPro IPR007844 http://www.ebi.ac.uk/interpro/entry/IPR007844 KEGG_Gene ecj:JW3492 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3492 KEGG_Gene eco:b3524 http://www.genome.jp/dbget-bin/www_bget?eco:b3524 KEGG_Orthology KO:K07290 http://www.genome.jp/dbget-bin/www_bget?KO:K07290 PSORT swissprot:YHJG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHJG_ECOLI PSORT-B swissprot:YHJG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHJG_ECOLI PSORT2 swissprot:YHJG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHJG_ECOLI Pfam PF05170 http://pfam.xfam.org/family/PF05170 Phobius swissprot:YHJG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHJG_ECOLI ProteinModelPortal P37645 http://www.proteinmodelportal.org/query/uniprot/P37645 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417981 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417981 RefSeq WP_001296794 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001296794 STRING 511145.b3524 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3524&targetmode=cogs STRING COG2982 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2982&targetmode=cogs TCDB 9.B.121.1 http://www.tcdb.org/search/result.php?tc=9.B.121.1 UniProtKB YHJG_ECOLI http://www.uniprot.org/uniprot/YHJG_ECOLI UniProtKB-AC P37645 http://www.uniprot.org/uniprot/P37645 charge swissprot:YHJG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHJG_ECOLI eggNOG COG2982 http://eggnogapi.embl.de/nog_data/html/tree/COG2982 eggNOG ENOG41066T0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41066T0 epestfind swissprot:YHJG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHJG_ECOLI garnier swissprot:YHJG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHJG_ECOLI helixturnhelix swissprot:YHJG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHJG_ECOLI hmoment swissprot:YHJG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHJG_ECOLI iep swissprot:YHJG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHJG_ECOLI inforesidue swissprot:YHJG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHJG_ECOLI octanol swissprot:YHJG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHJG_ECOLI pepcoil swissprot:YHJG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHJG_ECOLI pepdigest swissprot:YHJG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHJG_ECOLI pepinfo swissprot:YHJG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHJG_ECOLI pepnet swissprot:YHJG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHJG_ECOLI pepstats swissprot:YHJG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHJG_ECOLI pepwheel swissprot:YHJG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHJG_ECOLI pepwindow swissprot:YHJG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHJG_ECOLI sigcleave swissprot:YHJG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHJG_ECOLI ## Database ID URL or Descriptions # BioGrid 4261086 9 # CDD cd06174 MFS # EcoGene EG11262 tsgA # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_function GO:0022891 substrate-specific transmembrane transporter activity; IBA:GO_Central. # GO_process GO:0072714 response to selenite ion; IEP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0008150 biological_process # HAMAP MF_01044 MFS_TsgA # INDUCTION By selenite or tellurite. Maximal expression was detected at concentrations of 10.0 and 0.5 micrograms/ml for sodium selenite and sodium tellurite, respectively. {ECO:0000269|PubMed 11055951}. # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # InterPro IPR023528 MFS_TsgA # KEGG_Brite ko02000 Transporters # Organism TSGA_ECOLI Escherichia coli (strain K12) # PATRIC 32122162 VBIEscCol129921_3458 # PIR G65130 G65130 # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TSGA_ECOLI Protein TsgA # RefSeq NP_417823 NC_000913.3 # RefSeq WP_000185247 NZ_LN832404.1 # SIMILARITY Belongs to the major facilitator superfamily. TsgA family. {ECO 0000305}. # SUBCELLULAR LOCATION TSGA_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.7.14 the major facilitator superfamily (mfs) # eggNOG COG0477 LUCA # eggNOG ENOG4106DTQ Bacteria BLAST swissprot:TSGA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TSGA_ECOLI BioCyc ECOL316407:JW3327-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3327-MONOMER BioCyc EcoCyc:YHFC-MONOMER http://biocyc.org/getid?id=EcoCyc:YHFC-MONOMER COG COG0477 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0477 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/17.10.3865 http://dx.doi.org/10.1093/nar/17.10.3865 DOI 10.1111/j.1432-1033.1990.tb19125.x http://dx.doi.org/10.1111/j.1432-1033.1990.tb19125.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AEM.66.11.4972-4978.2000 http://dx.doi.org/10.1128/AEM.66.11.4972-4978.2000 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M28363 http://www.ebi.ac.uk/ena/data/view/M28363 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X14202 http://www.ebi.ac.uk/ena/data/view/X14202 EchoBASE EB1242 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1242 EcoGene EG11262 http://www.ecogene.org/geneInfo.php?eg_id=EG11262 EnsemblBacteria AAC76389 http://www.ensemblgenomes.org/id/AAC76389 EnsemblBacteria AAC76389 http://www.ensemblgenomes.org/id/AAC76389 EnsemblBacteria BAE77926 http://www.ensemblgenomes.org/id/BAE77926 EnsemblBacteria BAE77926 http://www.ensemblgenomes.org/id/BAE77926 EnsemblBacteria BAE77926 http://www.ensemblgenomes.org/id/BAE77926 EnsemblBacteria b3364 http://www.ensemblgenomes.org/id/b3364 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0022891 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022891 GO_process GO:0072714 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072714 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 947869 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947869 HAMAP MF_01044 http://hamap.expasy.org/unirule/MF_01044 HOGENOM HOG000290517 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000290517&db=HOGENOM6 InParanoid P60778 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P60778 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 InterPro IPR023528 http://www.ebi.ac.uk/interpro/entry/IPR023528 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3327 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3327 KEGG_Gene eco:b3364 http://www.genome.jp/dbget-bin/www_bget?eco:b3364 KEGG_Orthology KO:K06141 http://www.genome.jp/dbget-bin/www_bget?KO:K06141 OMA RFGFVLM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RFGFVLM PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:TSGA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TSGA_ECOLI PSORT-B swissprot:TSGA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TSGA_ECOLI PSORT2 swissprot:TSGA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TSGA_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:TSGA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TSGA_ECOLI PhylomeDB P60778 http://phylomedb.org/?seqid=P60778 ProteinModelPortal P60778 http://www.proteinmodelportal.org/query/uniprot/P60778 PubMed 11055951 http://www.ncbi.nlm.nih.gov/pubmed/11055951 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2200672 http://www.ncbi.nlm.nih.gov/pubmed/2200672 PubMed 2543955 http://www.ncbi.nlm.nih.gov/pubmed/2543955 PubMed 2546924 http://www.ncbi.nlm.nih.gov/pubmed/2546924 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417823 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417823 RefSeq WP_000185247 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000185247 STRING 511145.b3364 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3364&targetmode=cogs STRING COG0477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0477&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.7.14 http://www.tcdb.org/search/result.php?tc=2.A.1.7.14 UniProtKB TSGA_ECOLI http://www.uniprot.org/uniprot/TSGA_ECOLI UniProtKB-AC P60778 http://www.uniprot.org/uniprot/P60778 charge swissprot:TSGA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TSGA_ECOLI eggNOG COG0477 http://eggnogapi.embl.de/nog_data/html/tree/COG0477 eggNOG ENOG4106DTQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106DTQ epestfind swissprot:TSGA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TSGA_ECOLI garnier swissprot:TSGA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TSGA_ECOLI helixturnhelix swissprot:TSGA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TSGA_ECOLI hmoment swissprot:TSGA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TSGA_ECOLI iep swissprot:TSGA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TSGA_ECOLI inforesidue swissprot:TSGA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TSGA_ECOLI octanol swissprot:TSGA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TSGA_ECOLI pepcoil swissprot:TSGA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TSGA_ECOLI pepdigest swissprot:TSGA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TSGA_ECOLI pepinfo swissprot:TSGA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TSGA_ECOLI pepnet swissprot:TSGA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TSGA_ECOLI pepstats swissprot:TSGA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TSGA_ECOLI pepwheel swissprot:TSGA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TSGA_ECOLI pepwindow swissprot:TSGA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TSGA_ECOLI sigcleave swissprot:TSGA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TSGA_ECOLI ## Database ID URL or Descriptions # BRENDA 1.1.1.61 2026 # BioGrid 4260959 7 # CATALYTIC ACTIVITY SQUU_ECOLI 2,3-dihydroxypropane-1-sulfonate + NAD(+) = 2- hydroxy-3-oxopropane-1-sulfonate + NADH. {ECO 0000255|HAMAP- Rule MF_01913, ECO 0000269|PubMed 24463506}. # EcoGene EG11847 yihU # FUNCTION SQUU_ECOLI Reduces 3-sulfolactaldehyde (SLA) to 2,3- dihydroxypropane 1-sulfonate (DHPS). {ECO 0000255|HAMAP- Rule MF_01913, ECO 0000269|PubMed 24463506}. # GO_function GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity; IEA:InterPro. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0047577 4-hydroxybutyrate dehydrogenase activity; IDA:EcoCyc. # GO_function GO:0051287 NAD binding; IEA:InterPro. # GO_function GO:0061596 3-sulfolactaldehyde reductase activity; IDA:EcoCyc. # GO_process GO:0009407 toxin catabolic process; IMP:EcoCyc. # GO_process GO:1902777 6-sulfoquinovose(1-) catabolic process; IEP:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0019748 secondary metabolic process # Gene3D 1.10.1040.10 -; 1. # Gene3D 3.40.50.720 -; 1. # HAMAP MF_01913 SLA_reductase # INDUCTION Induced during growth with sulfoquinovose. {ECO:0000269|PubMed 24463506}. # IntAct P0A9V8 7 # InterPro IPR002204 3-OH-isobutyrate_DH-rel_CS # InterPro IPR006115 6PGDH_NADP-bd # InterPro IPR008927 6-PGluconate_DH_C-like # InterPro IPR013328 6PGD_dom_2 # InterPro IPR015815 HIBADH-related # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR029154 NADP-bd # InterPro IPR030876 SLA_reductase # KEGG_Brite ko01000 Enzymes # Organism SQUU_ECOLI Escherichia coli (strain K12) # PATRIC 32123267 VBIEscCol129921_3994 # PIR S40826 S40826 # PIRSF PIRSF000103 HIBADH # PROSITE PS00895 3_HYDROXYISOBUT_DH # Pfam PF03446 NAD_binding_2 # Pfam PF14833 NAD_binding_11 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 3-sulfolactaldehyde reductase {ECO:0000255|HAMAP-Rule MF_01913} # RefSeq NP_418318 NC_000913.3 # RefSeq WP_000718893 NZ_LN832404.1 # SIMILARITY Belongs to the 3-hydroxyisobutyrate dehydrogenase family. {ECO:0000255|HAMAP-Rule MF_01913}. # SUPFAM SSF48179 SSF48179 # SUPFAM SSF51735 SSF51735 # eggNOG COG2084 LUCA # eggNOG ENOG4105CF3 Bacteria BLAST swissprot:SQUU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SQUU_ECOLI BioCyc ECOL316407:JW3853-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3853-MONOMER BioCyc EcoCyc:EG11847-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11847-MONOMER BioCyc MetaCyc:EG11847-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11847-MONOMER COG COG2084 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2084 DIP DIP-48142N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48142N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature12947 http://dx.doi.org/10.1038/nature12947 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.373 {ECO:0000255|HAMAP-Rule:MF_01913} http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.373 {ECO:0000255|HAMAP-Rule:MF_01913} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.1.1.373 {ECO:0000255|HAMAP-Rule:MF_01913} http://enzyme.expasy.org/EC/1.1.1.373 {ECO:0000255|HAMAP-Rule:MF_01913} EchoBASE EB1793 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1793 EcoGene EG11847 http://www.ecogene.org/geneInfo.php?eg_id=EG11847 EnsemblBacteria AAD13444 http://www.ensemblgenomes.org/id/AAD13444 EnsemblBacteria AAD13444 http://www.ensemblgenomes.org/id/AAD13444 EnsemblBacteria BAE77427 http://www.ensemblgenomes.org/id/BAE77427 EnsemblBacteria BAE77427 http://www.ensemblgenomes.org/id/BAE77427 EnsemblBacteria BAE77427 http://www.ensemblgenomes.org/id/BAE77427 EnsemblBacteria b3882 http://www.ensemblgenomes.org/id/b3882 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004616 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004616 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0047577 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047577 GO_function GO:0051287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051287 GO_function GO:0061596 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061596 GO_process GO:0009407 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009407 GO_process GO:1902777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902777 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0019748 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019748 Gene3D 1.10.1040.10 http://www.cathdb.info/version/latest/superfamily/1.10.1040.10 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 948372 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948372 HAMAP MF_01913 http://hamap.expasy.org/unirule/MF_01913 HOGENOM HOG000219610 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219610&db=HOGENOM6 InParanoid P0A9V8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9V8 IntAct P0A9V8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9V8* IntEnz 1.1.1.373 {ECO:0000255|HAMAP-Rule:MF_01913} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.373 {ECO:0000255|HAMAP-Rule:MF_01913} InterPro IPR002204 http://www.ebi.ac.uk/interpro/entry/IPR002204 InterPro IPR006115 http://www.ebi.ac.uk/interpro/entry/IPR006115 InterPro IPR008927 http://www.ebi.ac.uk/interpro/entry/IPR008927 InterPro IPR013328 http://www.ebi.ac.uk/interpro/entry/IPR013328 InterPro IPR015815 http://www.ebi.ac.uk/interpro/entry/IPR015815 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR029154 http://www.ebi.ac.uk/interpro/entry/IPR029154 InterPro IPR030876 http://www.ebi.ac.uk/interpro/entry/IPR030876 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3853 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3853 KEGG_Gene eco:b3882 http://www.genome.jp/dbget-bin/www_bget?eco:b3882 KEGG_Orthology KO:K08318 http://www.genome.jp/dbget-bin/www_bget?KO:K08318 MINT MINT-1289833 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1289833 OMA PAGQHVE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PAGQHVE PROSITE PS00895 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00895 PSORT swissprot:SQUU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SQUU_ECOLI PSORT-B swissprot:SQUU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SQUU_ECOLI PSORT2 swissprot:SQUU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SQUU_ECOLI Pfam PF03446 http://pfam.xfam.org/family/PF03446 Pfam PF14833 http://pfam.xfam.org/family/PF14833 Phobius swissprot:SQUU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SQUU_ECOLI PhylomeDB P0A9V8 http://phylomedb.org/?seqid=P0A9V8 ProteinModelPortal P0A9V8 http://www.proteinmodelportal.org/query/uniprot/P0A9V8 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 24463506 http://www.ncbi.nlm.nih.gov/pubmed/24463506 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418318 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418318 RefSeq WP_000718893 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000718893 SMR P0A9V8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9V8 STRING 511145.b3882 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3882&targetmode=cogs STRING COG2084 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2084&targetmode=cogs SUPFAM SSF48179 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48179 SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB SQUU_ECOLI http://www.uniprot.org/uniprot/SQUU_ECOLI UniProtKB-AC P0A9V8 http://www.uniprot.org/uniprot/P0A9V8 charge swissprot:SQUU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SQUU_ECOLI eggNOG COG2084 http://eggnogapi.embl.de/nog_data/html/tree/COG2084 eggNOG ENOG4105CF3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CF3 epestfind swissprot:SQUU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SQUU_ECOLI garnier swissprot:SQUU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SQUU_ECOLI helixturnhelix swissprot:SQUU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SQUU_ECOLI hmoment swissprot:SQUU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SQUU_ECOLI iep swissprot:SQUU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SQUU_ECOLI inforesidue swissprot:SQUU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SQUU_ECOLI octanol swissprot:SQUU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SQUU_ECOLI pepcoil swissprot:SQUU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SQUU_ECOLI pepdigest swissprot:SQUU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SQUU_ECOLI pepinfo swissprot:SQUU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SQUU_ECOLI pepnet swissprot:SQUU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SQUU_ECOLI pepstats swissprot:SQUU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SQUU_ECOLI pepwheel swissprot:SQUU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SQUU_ECOLI pepwindow swissprot:SQUU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SQUU_ECOLI sigcleave swissprot:SQUU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SQUU_ECOLI ## Database ID URL or Descriptions # AltName CRP_ECOLI Catabolite activator protein # AltName CRP_ECOLI Catabolite gene activator # AltName CRP_ECOLI cAMP receptor protein # AltName CRP_ECOLI cAMP regulatory protein # DISRUPTION PHENOTYPE CRP_ECOLI Not essential (on rich medium), greatly increased levels of cAMP. Eliminates the NaCl sensitivity of an rnlA deletion mutant. {ECO 0000269|PubMed 15520470, ECO 0000269|PubMed 164435, ECO 0000269|PubMed 19019153}. # DOMAIN CRP_ECOLI The N-terminal domain binds cAMP and is responsible for homodimerization, while the C-terminal domain binds DNA when cAMP is bound. {ECO 0000269|PubMed 2828639, ECO 0000269|PubMed 6286624}. # ENZYME REGULATION CRP_ECOLI In the apo-form the DNA-binding helices form a rigid body in which their DNA recognitions helices are buried. cAMP binding causes a coil-to helix transition, stabilizing the active DNA binding conformation by reorienting and elongating these helices, which precludes a return to the inactive state. {ECO 0000269|PubMed 19359484, ECO 0000269|PubMed 19805344}. # EcoGene EG10164 crp # FUNCTION CRP_ECOLI A global transcription regulator. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding (to consensus sequence 5'-AAATGTGATCTAGATCACATTT-3') to directly regulate the transcription of about 300 genes in about 200 operons and indirectly regulate the expression of about half the genome. There are 3 classes of CRP promoters; class I promoters have a single CRP-binding site upstream of the RNA polymerase (RNAP)- binding site, whereas in class II promoters the single CRP- and RNAP-binding site overlap, CRP making multiple contacts with RNAP. Class III promoters require multiple activator molecules, including at least one CRP dimer. It can act as an activator, repressor, coactivator or corepressor. Induces a severe bend in DNA (about 87 degrees), bringing upstream promoter elements into contact with RNAP. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP. High levels of active CRP are detrimental to growth (PubMed 16260780). Plays a major role in carbon catabolite repression (CCR). CCR involves cAMP, adenylate cyclase (cyaA), CRP and the EIIA-Glc component of the PTS (crr). In the presence of glucose EIIA-Glc is dephosphorylated, and does not activate adenylate cyclase, leading to reduced cAMP and thus decreased CRP activity. Also plays a role in many other processes (see PubMed 22573269). {ECO 0000269|PubMed 10860739, ECO 0000269|PubMed 10860740, ECO 0000269|PubMed 15520470, ECO 0000269|PubMed 16260780, ECO 0000269|PubMed 16301522, ECO 0000269|PubMed 1646077, ECO 0000269|PubMed 2982847, ECO 0000269|PubMed 7966284, ECO 0000269|PubMed 8392187, ECO 0000269|PubMed 8978616}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_function GO:0030552 cAMP binding; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0045013 carbon catabolite repression of transcription; IMP:EcoCyc. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IDA:EcoliWiki. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IDA:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # Gene3D 2.60.120.10 -; 1. # INDUCTION CRP_ECOLI Constitutively expressed, levels decrease in stationary phase; more strongly induced in an rnlA deletion mutant, levels remain high even in stationary phase (at protein level). Both positively (PubMed 1328816) and negatively autoregulated (PubMed 6297782). {ECO 0000269|PubMed 1328816, ECO 0000269|PubMed 19019153, ECO 0000269|PubMed 6297782}. # INTERACTION CRP_ECOLI P0AFG0 nusG; NbExp=2; IntAct=EBI-547513, EBI-369628; P23862 priC; NbExp=2; IntAct=EBI-547513, EBI-1117383; P0A8E5 yacL; NbExp=3; IntAct=EBI-547513, EBI-554965; # IntAct P0ACJ8 39 # InterPro IPR000595 cNMP-bd_dom # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR012318 HTH_CRP # InterPro IPR014710 RmlC-like_jellyroll # InterPro IPR018335 Tscrpt_reg_HTH_Crp-type_CS # InterPro IPR018488 cNMP-bd_CS # InterPro IPR018490 cNMP-bd-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko03000 Transcription factors # KEGG_Pathway ko02020 Two-component system # KEGG_Pathway ko05111 Vibrio cholerae pathogenic cycle # MISCELLANEOUS Binds 2 cAMP; cAMP 1 is in the anti conformation, while cAMP 2 is in the syn conformation. {ECO:0000305|PubMed 9096308}. # Organism CRP_ECOLI Escherichia coli (strain K12) # PATRIC 32122148 VBIEscCol129921_3451 # PDB 1CGP X-ray; 3.00 A; A/B=2-206 # PDB 1G6N X-ray; 2.10 A; A/B=1-210 # PDB 1HW5 X-ray; 1.82 A; A/B=1-210 # PDB 1I5Z X-ray; 1.90 A; A/B=2-210 # PDB 1I6X X-ray; 2.20 A; A/B=2-210 # PDB 1J59 X-ray; 2.50 A; A/B=2-210 # PDB 1LB2 X-ray; 3.10 A; A=2-210 # PDB 1O3Q X-ray; 3.00 A; A=9-208 # PDB 1O3R X-ray; 3.00 A; A=9-208 # PDB 1O3S X-ray; 3.00 A; A=9-208 # PDB 1O3T X-ray; 2.80 A; A/B=9-208 # PDB 1RUN X-ray; 2.70 A; A/B=2-210 # PDB 1RUO X-ray; 2.70 A; A/B=2-210 # PDB 1ZRC X-ray; 2.80 A; A/B=2-210 # PDB 1ZRD X-ray; 2.80 A; A/B=2-210 # PDB 1ZRE X-ray; 2.80 A; A/B=2-210 # PDB 1ZRF X-ray; 2.10 A; A/B=2-210 # PDB 2CGP X-ray; 2.20 A; A=1-210 # PDB 2GAP Model; -; A/B=2-209 # PDB 2GZW X-ray; 2.21 A; A/B/C/D=2-210 # PDB 2WC2 NMR; -; A/B=2-210 # PDB 3FWE X-ray; 2.30 A; A/B=1-210 # PDB 3HIF X-ray; 3.59 A; A/B/C/D/E/F=1-210 # PDB 3IYD EM; -; G/H=2-210 # PDB 3KCC X-ray; 1.66 A; A/B=1-210 # PDB 3N4M X-ray; 2.99 A; A=2-210 # PDB 3QOP X-ray; 1.96 A; A/B=1-210 # PDB 3RDI X-ray; 2.95 A; A/B=1-210 # PDB 3ROU X-ray; 2.10 A; A/B=1-210 # PDB 3RPQ X-ray; 2.61 A; A/B=1-210 # PDB 3RYP X-ray; 1.60 A; A/B=1-210 # PDB 3RYR X-ray; 2.70 A; A/B=1-210 # PDB 4BH9 NMR; -; A=2-210 # PDB 4BHP NMR; -; A=2-210 # PDB 4FT8 X-ray; 1.97 A; A/B=2-210 # PDB 4HZF X-ray; 1.48 A; A/B=1-210 # PDB 4I01 X-ray; 2.30 A; A/B=1-210 # PDB 4I02 X-ray; 1.75 A; A/B/C/D/E/F=1-210 # PDB 4I09 X-ray; 2.05 A; A/B=1-210 # PDB 4I0A X-ray; 2.20 A; A/B=1-210 # PDB 4I0B X-ray; 1.50 A; A/B=1-210 # PDB 4R8H X-ray; 1.46 A; A/B=1-210 # PDB 5CIZ X-ray; 5.01 A; A=2-210 # PIR A93416 QRECC # PRINTS PR00034 HTHCRP # PROSITE PS00042 HTH_CRP_1 # PROSITE PS00888 CNMP_BINDING_1 # PROSITE PS00889 CNMP_BINDING_2 # PROSITE PS50042 CNMP_BINDING_3 # PROSITE PS51063 HTH_CRP_2 # Pfam PF00027 cNMP_binding # Pfam PF00325 Crp # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CRP_ECOLI cAMP-activated global transcriptional regulator CRP # RefSeq NP_417816 NC_000913.3 # RefSeq WP_000242755 NZ_CP014272.1 # SIMILARITY Contains 1 HTH crp-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00387}. # SIMILARITY Contains 1 cyclic nucleotide-binding domain. {ECO:0000255|PROSITE-ProRule PRU00060}. # SMART SM00100 cNMP # SMART SM00419 HTH_CRP # SUBUNIT CRP_ECOLI Homodimer, which upon binding cAMP is able to bind DNA. AR1 of the upstream subunit binds to the C-terminus of RNAP subunit RpoA, AR2 of the downstream subunit binds to the N- terminus of RpoA while AR3 binds to sigma-70 (RpoD). {ECO 0000269|PubMed 11124031, ECO 0000269|PubMed 12202833, ECO 0000269|PubMed 1646077, ECO 0000269|PubMed 1653449, ECO 0000269|PubMed 19359484, ECO 0000269|PubMed 19805344, ECO 0000269|PubMed 19903881, ECO 0000269|PubMed 2828639, ECO 0000269|PubMed 2839152, ECO 0000269|PubMed 6286624, ECO 0000269|PubMed 8757802, ECO 0000269|PubMed 8978616, ECO 0000269|PubMed 9096308, ECO 0000269|Ref.41}. # SUPFAM SSF46785 SSF46785 # SUPFAM SSF51206 SSF51206 # eggNOG COG0664 LUCA BLAST swissprot:CRP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CRP_ECOLI BioCyc ECOL316407:JW5702-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5702-MONOMER BioCyc EcoCyc:PD00257 http://biocyc.org/getid?id=EcoCyc:PD00257 COG COG0664 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0664 DIP DIP-29232N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-29232N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/jmbi.1996.0409 http://dx.doi.org/10.1006/jmbi.1996.0409 DOI 10.1006/jmbi.1999.3161 http://dx.doi.org/10.1006/jmbi.1999.3161 DOI 10.1006/jmbi.2000.3736 http://dx.doi.org/10.1006/jmbi.2000.3736 DOI 10.1006/jmbi.2000.3737 http://dx.doi.org/10.1006/jmbi.2000.3737 DOI 10.1006/jmbi.2000.4231 http://dx.doi.org/10.1006/jmbi.2000.4231 DOI 10.1007/s00253-012-4101-5 http://dx.doi.org/10.1007/s00253-012-4101-5 DOI 10.1016/0022-2836(87)90315-9 http://dx.doi.org/10.1016/0022-2836(87)90315-9 DOI 10.1016/0022-2836(94)90034-5 http://dx.doi.org/10.1016/0022-2836(94)90034-5 DOI 10.1016/0092-8674(83)90504-4 http://dx.doi.org/10.1016/0092-8674(83)90504-4 DOI 10.1016/0092-8674(91)90553-B http://dx.doi.org/10.1016/0092-8674(91)90553-B DOI 10.1016/S0092-8674(00)81806-1 http://dx.doi.org/10.1016/S0092-8674(00)81806-1 DOI 10.1016/j.bbapap.2009.04.015 http://dx.doi.org/10.1016/j.bbapap.2009.04.015 DOI 10.1021/bi0362166 http://dx.doi.org/10.1021/bi0362166 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nchembio.1250 http://dx.doi.org/10.1038/nchembio.1250 DOI 10.1042/bj2500897 http://dx.doi.org/10.1042/bj2500897 DOI 10.1042/bj2530801 http://dx.doi.org/10.1042/bj2530801 DOI 10.1073/pnas.0506687102 http://dx.doi.org/10.1073/pnas.0506687102 DOI 10.1073/pnas.0900595106 http://dx.doi.org/10.1073/pnas.0900595106 DOI 10.1073/pnas.0908380106 http://dx.doi.org/10.1073/pnas.0908380106 DOI 10.1073/pnas.0908782106 http://dx.doi.org/10.1073/pnas.0908782106 DOI 10.1073/pnas.90.1.75 http://dx.doi.org/10.1073/pnas.90.1.75 DOI 10.1073/pnas.90.13.6081 http://dx.doi.org/10.1073/pnas.90.13.6081 DOI 10.1073/pnas.94.7.2843 http://dx.doi.org/10.1073/pnas.94.7.2843 DOI 10.1074/jbc.M509421200 http://dx.doi.org/10.1074/jbc.M509421200 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/nar/10.4.1345 http://dx.doi.org/10.1093/nar/10.4.1345 DOI 10.1093/nar/10.4.1363 http://dx.doi.org/10.1093/nar/10.4.1363 DOI 10.1093/nar/gkh908 http://dx.doi.org/10.1093/nar/gkh908 DOI 10.1093/protein/1.3.201 http://dx.doi.org/10.1093/protein/1.3.201 DOI 10.1111/j.1365-2958.2008.06504.x http://dx.doi.org/10.1111/j.1365-2958.2008.06504.x DOI 10.1126/science.1076376 http://dx.doi.org/10.1126/science.1076376 DOI 10.1126/science.1653449 http://dx.doi.org/10.1126/science.1653449 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1146/annurev.bi.62.070193.003533 http://dx.doi.org/10.1146/annurev.bi.62.070193.003533 DOI 10.1266/ggs.82.291 http://dx.doi.org/10.1266/ggs.82.291 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01598 http://www.ebi.ac.uk/ena/data/view/J01598 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB0162 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0162 EcoGene EG10164 http://www.ecogene.org/geneInfo.php?eg_id=EG10164 EnsemblBacteria AAC76382 http://www.ensemblgenomes.org/id/AAC76382 EnsemblBacteria AAC76382 http://www.ensemblgenomes.org/id/AAC76382 EnsemblBacteria BAE77933 http://www.ensemblgenomes.org/id/BAE77933 EnsemblBacteria BAE77933 http://www.ensemblgenomes.org/id/BAE77933 EnsemblBacteria BAE77933 http://www.ensemblgenomes.org/id/BAE77933 EnsemblBacteria b3357 http://www.ensemblgenomes.org/id/b3357 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0030552 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030552 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045013 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045013 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 2.60.120.10 http://www.cathdb.info/version/latest/superfamily/2.60.120.10 GeneID 947867 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947867 HOGENOM HOG000250565 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000250565&db=HOGENOM6 InParanoid P0ACJ8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACJ8 IntAct P0ACJ8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACJ8* InterPro IPR000595 http://www.ebi.ac.uk/interpro/entry/IPR000595 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR012318 http://www.ebi.ac.uk/interpro/entry/IPR012318 InterPro IPR014710 http://www.ebi.ac.uk/interpro/entry/IPR014710 InterPro IPR018335 http://www.ebi.ac.uk/interpro/entry/IPR018335 InterPro IPR018488 http://www.ebi.ac.uk/interpro/entry/IPR018488 InterPro IPR018490 http://www.ebi.ac.uk/interpro/entry/IPR018490 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW5702 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5702 KEGG_Gene eco:b3357 http://www.genome.jp/dbget-bin/www_bget?eco:b3357 KEGG_Orthology KO:K10914 http://www.genome.jp/dbget-bin/www_bget?KO:K10914 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 KEGG_Pathway ko05111 http://www.genome.jp/kegg-bin/show_pathway?ko05111 MINT MINT-1249660 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1249660 OMA KTMVVYG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KTMVVYG PDB 1CGP http://www.ebi.ac.uk/pdbe-srv/view/entry/1CGP PDB 1G6N http://www.ebi.ac.uk/pdbe-srv/view/entry/1G6N PDB 1HW5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1HW5 PDB 1I5Z http://www.ebi.ac.uk/pdbe-srv/view/entry/1I5Z PDB 1I6X http://www.ebi.ac.uk/pdbe-srv/view/entry/1I6X PDB 1J59 http://www.ebi.ac.uk/pdbe-srv/view/entry/1J59 PDB 1LB2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1LB2 PDB 1O3Q http://www.ebi.ac.uk/pdbe-srv/view/entry/1O3Q PDB 1O3R http://www.ebi.ac.uk/pdbe-srv/view/entry/1O3R PDB 1O3S http://www.ebi.ac.uk/pdbe-srv/view/entry/1O3S PDB 1O3T http://www.ebi.ac.uk/pdbe-srv/view/entry/1O3T PDB 1RUN http://www.ebi.ac.uk/pdbe-srv/view/entry/1RUN PDB 1RUO http://www.ebi.ac.uk/pdbe-srv/view/entry/1RUO PDB 1ZRC http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZRC PDB 1ZRD http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZRD PDB 1ZRE http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZRE PDB 1ZRF http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZRF PDB 2CGP http://www.ebi.ac.uk/pdbe-srv/view/entry/2CGP PDB 2GAP http://www.ebi.ac.uk/pdbe-srv/view/entry/2GAP PDB 2GZW http://www.ebi.ac.uk/pdbe-srv/view/entry/2GZW PDB 2WC2 http://www.ebi.ac.uk/pdbe-srv/view/entry/2WC2 PDB 3FWE http://www.ebi.ac.uk/pdbe-srv/view/entry/3FWE PDB 3HIF http://www.ebi.ac.uk/pdbe-srv/view/entry/3HIF PDB 3IYD http://www.ebi.ac.uk/pdbe-srv/view/entry/3IYD PDB 3KCC http://www.ebi.ac.uk/pdbe-srv/view/entry/3KCC PDB 3N4M http://www.ebi.ac.uk/pdbe-srv/view/entry/3N4M PDB 3QOP http://www.ebi.ac.uk/pdbe-srv/view/entry/3QOP PDB 3RDI http://www.ebi.ac.uk/pdbe-srv/view/entry/3RDI PDB 3ROU http://www.ebi.ac.uk/pdbe-srv/view/entry/3ROU PDB 3RPQ http://www.ebi.ac.uk/pdbe-srv/view/entry/3RPQ PDB 3RYP http://www.ebi.ac.uk/pdbe-srv/view/entry/3RYP PDB 3RYR http://www.ebi.ac.uk/pdbe-srv/view/entry/3RYR PDB 4BH9 http://www.ebi.ac.uk/pdbe-srv/view/entry/4BH9 PDB 4BHP http://www.ebi.ac.uk/pdbe-srv/view/entry/4BHP PDB 4FT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4FT8 PDB 4HZF http://www.ebi.ac.uk/pdbe-srv/view/entry/4HZF PDB 4I01 http://www.ebi.ac.uk/pdbe-srv/view/entry/4I01 PDB 4I02 http://www.ebi.ac.uk/pdbe-srv/view/entry/4I02 PDB 4I09 http://www.ebi.ac.uk/pdbe-srv/view/entry/4I09 PDB 4I0A http://www.ebi.ac.uk/pdbe-srv/view/entry/4I0A PDB 4I0B http://www.ebi.ac.uk/pdbe-srv/view/entry/4I0B PDB 4R8H http://www.ebi.ac.uk/pdbe-srv/view/entry/4R8H PDB 5CIZ http://www.ebi.ac.uk/pdbe-srv/view/entry/5CIZ PDBsum 1CGP http://www.ebi.ac.uk/pdbsum/1CGP PDBsum 1G6N http://www.ebi.ac.uk/pdbsum/1G6N PDBsum 1HW5 http://www.ebi.ac.uk/pdbsum/1HW5 PDBsum 1I5Z http://www.ebi.ac.uk/pdbsum/1I5Z PDBsum 1I6X http://www.ebi.ac.uk/pdbsum/1I6X PDBsum 1J59 http://www.ebi.ac.uk/pdbsum/1J59 PDBsum 1LB2 http://www.ebi.ac.uk/pdbsum/1LB2 PDBsum 1O3Q http://www.ebi.ac.uk/pdbsum/1O3Q PDBsum 1O3R http://www.ebi.ac.uk/pdbsum/1O3R PDBsum 1O3S http://www.ebi.ac.uk/pdbsum/1O3S PDBsum 1O3T http://www.ebi.ac.uk/pdbsum/1O3T PDBsum 1RUN http://www.ebi.ac.uk/pdbsum/1RUN PDBsum 1RUO http://www.ebi.ac.uk/pdbsum/1RUO PDBsum 1ZRC http://www.ebi.ac.uk/pdbsum/1ZRC PDBsum 1ZRD http://www.ebi.ac.uk/pdbsum/1ZRD PDBsum 1ZRE http://www.ebi.ac.uk/pdbsum/1ZRE PDBsum 1ZRF http://www.ebi.ac.uk/pdbsum/1ZRF PDBsum 2CGP http://www.ebi.ac.uk/pdbsum/2CGP PDBsum 2GAP http://www.ebi.ac.uk/pdbsum/2GAP PDBsum 2GZW http://www.ebi.ac.uk/pdbsum/2GZW PDBsum 2WC2 http://www.ebi.ac.uk/pdbsum/2WC2 PDBsum 3FWE http://www.ebi.ac.uk/pdbsum/3FWE PDBsum 3HIF http://www.ebi.ac.uk/pdbsum/3HIF PDBsum 3IYD http://www.ebi.ac.uk/pdbsum/3IYD PDBsum 3KCC http://www.ebi.ac.uk/pdbsum/3KCC PDBsum 3N4M http://www.ebi.ac.uk/pdbsum/3N4M PDBsum 3QOP http://www.ebi.ac.uk/pdbsum/3QOP PDBsum 3RDI http://www.ebi.ac.uk/pdbsum/3RDI PDBsum 3ROU http://www.ebi.ac.uk/pdbsum/3ROU PDBsum 3RPQ http://www.ebi.ac.uk/pdbsum/3RPQ PDBsum 3RYP http://www.ebi.ac.uk/pdbsum/3RYP PDBsum 3RYR http://www.ebi.ac.uk/pdbsum/3RYR PDBsum 4BH9 http://www.ebi.ac.uk/pdbsum/4BH9 PDBsum 4BHP http://www.ebi.ac.uk/pdbsum/4BHP PDBsum 4FT8 http://www.ebi.ac.uk/pdbsum/4FT8 PDBsum 4HZF http://www.ebi.ac.uk/pdbsum/4HZF PDBsum 4I01 http://www.ebi.ac.uk/pdbsum/4I01 PDBsum 4I02 http://www.ebi.ac.uk/pdbsum/4I02 PDBsum 4I09 http://www.ebi.ac.uk/pdbsum/4I09 PDBsum 4I0A http://www.ebi.ac.uk/pdbsum/4I0A PDBsum 4I0B http://www.ebi.ac.uk/pdbsum/4I0B PDBsum 4R8H http://www.ebi.ac.uk/pdbsum/4R8H PDBsum 5CIZ http://www.ebi.ac.uk/pdbsum/5CIZ PRINTS PR00034 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00034 PROSITE PS00042 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00042 PROSITE PS00888 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00888 PROSITE PS00889 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00889 PROSITE PS50042 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50042 PROSITE PS51063 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51063 PSORT swissprot:CRP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CRP_ECOLI PSORT-B swissprot:CRP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CRP_ECOLI PSORT2 swissprot:CRP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CRP_ECOLI Pfam PF00027 http://pfam.xfam.org/family/PF00027 Pfam PF00325 http://pfam.xfam.org/family/PF00325 Phobius swissprot:CRP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CRP_ECOLI PhylomeDB P0ACJ8 http://phylomedb.org/?seqid=P0ACJ8 ProteinModelPortal P0ACJ8 http://www.proteinmodelportal.org/query/uniprot/P0ACJ8 PubMed 10550204 http://www.ncbi.nlm.nih.gov/pubmed/10550204 PubMed 10860739 http://www.ncbi.nlm.nih.gov/pubmed/10860739 PubMed 10860740 http://www.ncbi.nlm.nih.gov/pubmed/10860740 PubMed 11124031 http://www.ncbi.nlm.nih.gov/pubmed/11124031 PubMed 12202833 http://www.ncbi.nlm.nih.gov/pubmed/12202833 PubMed 1328816 http://www.ncbi.nlm.nih.gov/pubmed/1328816 PubMed 15096034 http://www.ncbi.nlm.nih.gov/pubmed/15096034 PubMed 15520470 http://www.ncbi.nlm.nih.gov/pubmed/15520470 PubMed 16260780 http://www.ncbi.nlm.nih.gov/pubmed/16260780 PubMed 16301522 http://www.ncbi.nlm.nih.gov/pubmed/16301522 PubMed 164435 http://www.ncbi.nlm.nih.gov/pubmed/164435 PubMed 1646077 http://www.ncbi.nlm.nih.gov/pubmed/1646077 PubMed 1653449 http://www.ncbi.nlm.nih.gov/pubmed/1653449 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17895580 http://www.ncbi.nlm.nih.gov/pubmed/17895580 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 19019153 http://www.ncbi.nlm.nih.gov/pubmed/19019153 PubMed 19359484 http://www.ncbi.nlm.nih.gov/pubmed/19359484 PubMed 19439203 http://www.ncbi.nlm.nih.gov/pubmed/19439203 PubMed 19805344 http://www.ncbi.nlm.nih.gov/pubmed/19805344 PubMed 19903881 http://www.ncbi.nlm.nih.gov/pubmed/19903881 PubMed 22573269 http://www.ncbi.nlm.nih.gov/pubmed/22573269 PubMed 23644478 http://www.ncbi.nlm.nih.gov/pubmed/23644478 PubMed 2828639 http://www.ncbi.nlm.nih.gov/pubmed/2828639 PubMed 2839152 http://www.ncbi.nlm.nih.gov/pubmed/2839152 PubMed 2845936 http://www.ncbi.nlm.nih.gov/pubmed/2845936 PubMed 2982847 http://www.ncbi.nlm.nih.gov/pubmed/2982847 PubMed 3333845 http://www.ncbi.nlm.nih.gov/pubmed/3333845 PubMed 6280140 http://www.ncbi.nlm.nih.gov/pubmed/6280140 PubMed 6280141 http://www.ncbi.nlm.nih.gov/pubmed/6280141 PubMed 6286624 http://www.ncbi.nlm.nih.gov/pubmed/6286624 PubMed 6297782 http://www.ncbi.nlm.nih.gov/pubmed/6297782 PubMed 7966284 http://www.ncbi.nlm.nih.gov/pubmed/7966284 PubMed 8380500 http://www.ncbi.nlm.nih.gov/pubmed/8380500 PubMed 8392187 http://www.ncbi.nlm.nih.gov/pubmed/8392187 PubMed 8394684 http://www.ncbi.nlm.nih.gov/pubmed/8394684 PubMed 8757802 http://www.ncbi.nlm.nih.gov/pubmed/8757802 PubMed 8978616 http://www.ncbi.nlm.nih.gov/pubmed/8978616 PubMed 9096308 http://www.ncbi.nlm.nih.gov/pubmed/9096308 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417816 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417816 RefSeq WP_000242755 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000242755 SMART SM00100 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00100 SMART SM00419 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00419 SMR P0ACJ8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACJ8 STRING 511145.b3357 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3357&targetmode=cogs STRING COG0664 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0664&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SUPFAM SSF51206 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51206 UniProtKB CRP_ECOLI http://www.uniprot.org/uniprot/CRP_ECOLI UniProtKB-AC P0ACJ8 http://www.uniprot.org/uniprot/P0ACJ8 charge swissprot:CRP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CRP_ECOLI eggNOG COG0664 http://eggnogapi.embl.de/nog_data/html/tree/COG0664 epestfind swissprot:CRP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CRP_ECOLI garnier swissprot:CRP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CRP_ECOLI helixturnhelix swissprot:CRP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CRP_ECOLI hmoment swissprot:CRP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CRP_ECOLI iep swissprot:CRP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CRP_ECOLI inforesidue swissprot:CRP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CRP_ECOLI octanol swissprot:CRP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CRP_ECOLI pepcoil swissprot:CRP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CRP_ECOLI pepdigest swissprot:CRP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CRP_ECOLI pepinfo swissprot:CRP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CRP_ECOLI pepnet swissprot:CRP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CRP_ECOLI pepstats swissprot:CRP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CRP_ECOLI pepwheel swissprot:CRP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CRP_ECOLI pepwindow swissprot:CRP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CRP_ECOLI sigcleave swissprot:CRP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CRP_ECOLI ## Database ID URL or Descriptions # BioGrid 4259410 279 # EcoGene EG11749 yadE # GO_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; IEA:InterPro. # GO_process GO:0005975 carbohydrate metabolic process; IEA:InterPro. # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_process GO:0005975 carbohydrate metabolic process # Gene3D 3.20.20.370 -; 1. # IntAct P31666 2 # InterPro IPR002509 NODB_dom # InterPro IPR011330 Glyco_hydro/deAcase_b/a-brl # Organism YADE_ECOLI Escherichia coli (strain K12) # PATRIC 32115363 VBIEscCol129921_0133 # PIR B64736 B64736 # PROSITE PS51677 NODB # Pfam PF01522 Polysacc_deac_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YADE_ECOLI Uncharacterized protein YadE # RefSeq NP_414672 NC_000913.3 # RefSeq WP_000277917 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA24275.1; Type=Frameshift; Positions=170; Evidence={ECO 0000305}; # SIMILARITY Contains 1 NodB homology domain. {ECO:0000255|PROSITE- ProRule PRU01014}. # SUPFAM SSF88713 SSF88713 # eggNOG COG0726 LUCA # eggNOG ENOG4107BJW Bacteria BLAST swissprot:YADE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YADE_ECOLI BioCyc ECOL316407:JW0126-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0126-MONOMER BioCyc EcoCyc:EG11749-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11749-MONOMER DIP DIP-11183N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11183N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L17086 http://www.ebi.ac.uk/ena/data/view/L17086 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1699 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1699 EcoGene EG11749 http://www.ecogene.org/geneInfo.php?eg_id=EG11749 EnsemblBacteria AAC73241 http://www.ensemblgenomes.org/id/AAC73241 EnsemblBacteria AAC73241 http://www.ensemblgenomes.org/id/AAC73241 EnsemblBacteria BAB96707 http://www.ensemblgenomes.org/id/BAB96707 EnsemblBacteria BAB96707 http://www.ensemblgenomes.org/id/BAB96707 EnsemblBacteria BAB96707 http://www.ensemblgenomes.org/id/BAB96707 EnsemblBacteria b0130 http://www.ensemblgenomes.org/id/b0130 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 Gene3D 3.20.20.370 http://www.cathdb.info/version/latest/superfamily/3.20.20.370 GeneID 946536 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946536 HOGENOM HOG000116855 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000116855&db=HOGENOM6 InParanoid P31666 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31666 IntAct P31666 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31666* InterPro IPR002509 http://www.ebi.ac.uk/interpro/entry/IPR002509 InterPro IPR011330 http://www.ebi.ac.uk/interpro/entry/IPR011330 KEGG_Gene ecj:JW0126 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0126 KEGG_Gene eco:b0130 http://www.genome.jp/dbget-bin/www_bget?eco:b0130 OMA LQFMSIS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LQFMSIS PROSITE PS51677 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51677 PSORT swissprot:YADE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YADE_ECOLI PSORT-B swissprot:YADE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YADE_ECOLI PSORT2 swissprot:YADE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YADE_ECOLI Pfam PF01522 http://pfam.xfam.org/family/PF01522 Phobius swissprot:YADE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YADE_ECOLI PhylomeDB P31666 http://phylomedb.org/?seqid=P31666 ProteinModelPortal P31666 http://www.proteinmodelportal.org/query/uniprot/P31666 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414672 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414672 RefSeq WP_000277917 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000277917 STRING 511145.b0130 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0130&targetmode=cogs SUPFAM SSF88713 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF88713 UniProtKB YADE_ECOLI http://www.uniprot.org/uniprot/YADE_ECOLI UniProtKB-AC P31666 http://www.uniprot.org/uniprot/P31666 charge swissprot:YADE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YADE_ECOLI eggNOG COG0726 http://eggnogapi.embl.de/nog_data/html/tree/COG0726 eggNOG ENOG4107BJW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107BJW epestfind swissprot:YADE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YADE_ECOLI garnier swissprot:YADE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YADE_ECOLI helixturnhelix swissprot:YADE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YADE_ECOLI hmoment swissprot:YADE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YADE_ECOLI iep swissprot:YADE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YADE_ECOLI inforesidue swissprot:YADE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YADE_ECOLI octanol swissprot:YADE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YADE_ECOLI pepcoil swissprot:YADE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YADE_ECOLI pepdigest swissprot:YADE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YADE_ECOLI pepinfo swissprot:YADE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YADE_ECOLI pepnet swissprot:YADE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YADE_ECOLI pepstats swissprot:YADE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YADE_ECOLI pepwheel swissprot:YADE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YADE_ECOLI pepwindow swissprot:YADE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YADE_ECOLI sigcleave swissprot:YADE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YADE_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES GHXP_ECOLI Kinetic parameters KM=1.6 uM for guanine {ECO 0000269|PubMed 24214977}; KM=11.2 uM for hypoxanthine {ECO 0000269|PubMed 24214977}; Vmax=4.0 nmol/min/mg enzyme with guanine as substrate {ECO 0000269|PubMed 24214977}; Vmax=2.7 nmol/min/mg enzyme with hypoxanthine as substrate {ECO 0000269|PubMed 24214977}; # BioGrid 4262672 290 # EcoGene EG11939 ghxP # FUNCTION GHXP_ECOLI High-affinity transporter for guanine and hypoxanthine. {ECO 0000269|PubMed 24214977}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015208 guanine transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0035344 hypoxanthine transport; IMP:EcoCyc. # GO_process GO:0061489 guanine import into cell; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR006043 Xant/urac/vitC # KEGG_Brite ko02000 Transporters # Organism GHXP_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11119 PTHR11119 # PATRIC 32123675 VBIEscCol129921_4186 # PIR G65214 G65214 # Pfam PF00860 Xan_ur_permease # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GHXP_ECOLI Guanine/hypoxanthine permease GhxP # RefSeq NP_418488 NC_000913.3 # RefSeq WP_000106882 NZ_LN832404.1 # SIMILARITY Belongs to the xanthine/uracil permease family. AzgA purine transporter (TC 2.A.1.40) subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION GHXP_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 24214977}; Multi- pass membrane protein {ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 24214977}. # TCDB 2.A.40.7:the nucleobase/ascorbate transporter (nat) or nucleobase cation symporter-2 (ncs2) family # eggNOG COG2252 LUCA # eggNOG ENOG4105C7N Bacteria BLAST swissprot:GHXP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GHXP_ECOLI BioCyc ECOL316407:JW4025-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4025-MONOMER BioCyc EcoCyc:EG11939-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11939-MONOMER BioCyc MetaCyc:EG11939-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11939-MONOMER COG COG2252 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2252 DIP DIP-48113N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48113N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M113.523340 http://dx.doi.org/10.1074/jbc.M113.523340 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1883 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1883 EcoGene EG11939 http://www.ecogene.org/geneInfo.php?eg_id=EG11939 EnsemblBacteria AAC77034 http://www.ensemblgenomes.org/id/AAC77034 EnsemblBacteria AAC77034 http://www.ensemblgenomes.org/id/AAC77034 EnsemblBacteria BAE78066 http://www.ensemblgenomes.org/id/BAE78066 EnsemblBacteria BAE78066 http://www.ensemblgenomes.org/id/BAE78066 EnsemblBacteria BAE78066 http://www.ensemblgenomes.org/id/BAE78066 EnsemblBacteria b4064 http://www.ensemblgenomes.org/id/b4064 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015208 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015208 GO_process GO:0035344 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035344 GO_process GO:0061489 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061489 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948565 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948565 HOGENOM HOG000244363 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000244363&db=HOGENOM6 InParanoid P0AF52 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AF52 IntAct P0AF52 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AF52* InterPro IPR006043 http://www.ebi.ac.uk/interpro/entry/IPR006043 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW4025 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4025 KEGG_Gene eco:b4064 http://www.genome.jp/dbget-bin/www_bget?eco:b4064 KEGG_Orthology KO:K06901 http://www.genome.jp/dbget-bin/www_bget?KO:K06901 MINT MINT-1260311 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1260311 OMA LFKFEER http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LFKFEER PANTHER PTHR11119 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11119 PSORT swissprot:GHXP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GHXP_ECOLI PSORT-B swissprot:GHXP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GHXP_ECOLI PSORT2 swissprot:GHXP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GHXP_ECOLI Pfam PF00860 http://pfam.xfam.org/family/PF00860 Phobius swissprot:GHXP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GHXP_ECOLI PhylomeDB P0AF52 http://phylomedb.org/?seqid=P0AF52 ProteinModelPortal P0AF52 http://www.proteinmodelportal.org/query/uniprot/P0AF52 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 24214977 http://www.ncbi.nlm.nih.gov/pubmed/24214977 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418488 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418488 RefSeq WP_000106882 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000106882 STRING 511145.b4064 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4064&targetmode=cogs STRING COG2252 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2252&targetmode=cogs TCDB 2.A.40.7 http://www.tcdb.org/search/result.php?tc=2.A.40.7 UniProtKB GHXP_ECOLI http://www.uniprot.org/uniprot/GHXP_ECOLI UniProtKB-AC P0AF52 http://www.uniprot.org/uniprot/P0AF52 charge swissprot:GHXP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GHXP_ECOLI eggNOG COG2252 http://eggnogapi.embl.de/nog_data/html/tree/COG2252 eggNOG ENOG4105C7N http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C7N epestfind swissprot:GHXP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GHXP_ECOLI garnier swissprot:GHXP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GHXP_ECOLI helixturnhelix swissprot:GHXP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GHXP_ECOLI hmoment swissprot:GHXP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GHXP_ECOLI iep swissprot:GHXP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GHXP_ECOLI inforesidue swissprot:GHXP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GHXP_ECOLI octanol swissprot:GHXP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GHXP_ECOLI pepcoil swissprot:GHXP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GHXP_ECOLI pepdigest swissprot:GHXP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GHXP_ECOLI pepinfo swissprot:GHXP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GHXP_ECOLI pepnet swissprot:GHXP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GHXP_ECOLI pepstats swissprot:GHXP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GHXP_ECOLI pepwheel swissprot:GHXP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GHXP_ECOLI pepwindow swissprot:GHXP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GHXP_ECOLI sigcleave swissprot:GHXP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GHXP_ECOLI ## Database ID URL or Descriptions # BioGrid 4260829 6 # EcoGene EG12700 gltI # FUNCTION GLTI_ECOLI Part of the ABC transporter complex GltIJKL involved in glutamate and aspartate uptake. Binds to both glutamate and aspartate. {ECO 0000269|PubMed 1091635, ECO 0000269|PubMed 1091636, ECO 0000269|PubMed 336628, ECO 0000305|PubMed 9593292}. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_process GO:0006865 amino acid transport; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0006810 transport # InterPro IPR001638 Solute-binding_3/MltF_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00230 Glutamate/aspartate transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism GLTI_ECOLI Escherichia coli (strain K12) # PATRIC 32116493 VBIEscCol129921_0686 # PIR E64800 E64800 # Pfam PF00497 SBP_bac_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Glutamate/aspartate import solute-binding protein {ECO 0000305} # RefSeq NP_415188 NC_000913.3 # RefSeq WP_001177086 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial solute-binding protein 3 family. {ECO 0000305}. # SMART SM00062 PBPb # SUBCELLULAR LOCATION GLTI_ECOLI Periplasm {ECO 0000269|PubMed 1091635}. # SUBUNIT The complex is composed of two ATP-binding proteins (GltL), two transmembrane proteins (GltJ and GltK) and a solute- binding protein (GltI). {ECO:0000305|PubMed 9593292}. # TCDB 3.A.1.3 the atp-binding cassette (abc) superfamily # eggNOG COG0834 LUCA # eggNOG ENOG4107RP9 Bacteria BLAST swissprot:GLTI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLTI_ECOLI BioCyc ECOL316407:JW5092-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5092-MONOMER BioCyc EcoCyc:G6359-MONOMER http://biocyc.org/getid?id=EcoCyc:G6359-MONOMER BioCyc MetaCyc:G6359-MONOMER http://biocyc.org/getid?id=MetaCyc:G6359-MONOMER COG COG0834 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0834 DIP DIP-11361N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11361N DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1998.00764.x http://dx.doi.org/10.1046/j.1365-2958.1998.00764.x DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U10981 http://www.ebi.ac.uk/ena/data/view/U10981 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB2562 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2562 EcoGene EG12700 http://www.ecogene.org/geneInfo.php?eg_id=EG12700 EnsemblBacteria AAC73756 http://www.ensemblgenomes.org/id/AAC73756 EnsemblBacteria AAC73756 http://www.ensemblgenomes.org/id/AAC73756 EnsemblBacteria BAA35307 http://www.ensemblgenomes.org/id/BAA35307 EnsemblBacteria BAA35307 http://www.ensemblgenomes.org/id/BAA35307 EnsemblBacteria BAA35307 http://www.ensemblgenomes.org/id/BAA35307 EnsemblBacteria b0655 http://www.ensemblgenomes.org/id/b0655 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_process GO:0006865 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 946938 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946938 HOGENOM HOG000031898 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000031898&db=HOGENOM6 InParanoid P37902 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37902 IntAct P37902 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37902* InterPro IPR001638 http://www.ebi.ac.uk/interpro/entry/IPR001638 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5092 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5092 KEGG_Gene eco:b0655 http://www.genome.jp/dbget-bin/www_bget?eco:b0655 KEGG_Orthology KO:K10001 http://www.genome.jp/dbget-bin/www_bget?KO:K10001 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA AMNADKQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AMNADKQ PSORT swissprot:GLTI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLTI_ECOLI PSORT-B swissprot:GLTI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLTI_ECOLI PSORT2 swissprot:GLTI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLTI_ECOLI Pfam PF00497 http://pfam.xfam.org/family/PF00497 Phobius swissprot:GLTI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLTI_ECOLI PhylomeDB P37902 http://phylomedb.org/?seqid=P37902 ProteinModelPortal P37902 http://www.proteinmodelportal.org/query/uniprot/P37902 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 1091635 http://www.ncbi.nlm.nih.gov/pubmed/1091635 PubMed 1091636 http://www.ncbi.nlm.nih.gov/pubmed/1091636 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 336628 http://www.ncbi.nlm.nih.gov/pubmed/336628 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9593292 http://www.ncbi.nlm.nih.gov/pubmed/9593292 RefSeq NP_415188 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415188 RefSeq WP_001177086 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001177086 SMART SM00062 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00062 SMR P37902 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37902 STRING 511145.b0655 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0655&targetmode=cogs STRING COG0834 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0834&targetmode=cogs SWISS-2DPAGE P37902 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P37902 TCDB 3.A.1.3 http://www.tcdb.org/search/result.php?tc=3.A.1.3 UniProtKB GLTI_ECOLI http://www.uniprot.org/uniprot/GLTI_ECOLI UniProtKB-AC P37902 http://www.uniprot.org/uniprot/P37902 charge swissprot:GLTI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLTI_ECOLI eggNOG COG0834 http://eggnogapi.embl.de/nog_data/html/tree/COG0834 eggNOG ENOG4107RP9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107RP9 epestfind swissprot:GLTI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLTI_ECOLI garnier swissprot:GLTI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLTI_ECOLI helixturnhelix swissprot:GLTI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLTI_ECOLI hmoment swissprot:GLTI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLTI_ECOLI iep swissprot:GLTI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLTI_ECOLI inforesidue swissprot:GLTI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLTI_ECOLI octanol swissprot:GLTI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLTI_ECOLI pepcoil swissprot:GLTI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLTI_ECOLI pepdigest swissprot:GLTI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLTI_ECOLI pepinfo swissprot:GLTI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLTI_ECOLI pepnet swissprot:GLTI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLTI_ECOLI pepstats swissprot:GLTI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLTI_ECOLI pepwheel swissprot:GLTI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLTI_ECOLI pepwindow swissprot:GLTI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLTI_ECOLI sigcleave swissprot:GLTI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLTI_ECOLI ## Database ID URL or Descriptions # AltName BGLB_ECOLI Phospho-beta-glucosidase B # BioGrid 4261195 13 # CATALYTIC ACTIVITY BGLB_ECOLI 6-phospho-beta-D-glucosyl-(1,4)-D-glucose + H(2)O = D-glucose + D-glucose 6-phosphate. # CAZy GH1 Glycoside Hydrolase Family 1 # EcoGene EG10114 bglB # FUNCTION BGLB_ECOLI Catalyzes the hydrolysis of phosphorylated beta- glucosides into glucose-6-phosphate (G-6-P) and aglycone. It has a high affinity for phosphorylated aromatic beta-glucosides (p- nitrophenyl-beta-glucoside, phenyl beta-glucoside, arbutin and phosphorylated salicin), and a low affinity for phosphorylated beta-methyl-glucoside. {ECO 0000269|PubMed 4576407}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds; ISS:UniProtKB. # GO_function GO:0008422 beta-glucosidase activity; IBA:GO_Central. # GO_function GO:0008706 6-phospho-beta-glucosidase activity; ISS:UniProtKB. # GO_process GO:0044724 single-organism carbohydrate catabolic process; IBA:GO_Central. # GO_process GO:1901657 glycosyl compound metabolic process; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # Gene3D 3.20.20.80 -; 1. # IntAct P11988 3 # InterPro IPR001360 Glyco_hydro_1 # InterPro IPR013781 Glyco_hydro_catalytic_dom # InterPro IPR017853 Glycoside_hydrolase_SF # InterPro IPR018120 Glyco_hydro_1_AS # InterPro IPR033132 Glyco_hydro_1_N_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00010 Glycolysis / Gluconeogenesis # MISCELLANEOUS BGLB_ECOLI Part of the cryptic bglGFBH operon. # Organism BGLB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10353 PTHR10353 # PATRIC 32122937 VBIEscCol129921_3844 # PIR B65175 B65175 # PRINTS PR00131 GLHYDRLASE1 # PROSITE PS00572 GLYCOSYL_HYDROL_F1_1 # PROSITE PS00653 GLYCOSYL_HYDROL_F1_2 # Pfam PF00232 Glyco_hydro_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BGLB_ECOLI 6-phospho-beta-glucosidase BglB # RefSeq NP_418177 NC_000913.3 # RefSeq WP_000643228 NZ_LN832404.1 # SIMILARITY Belongs to the glycosyl hydrolase 1 family. {ECO 0000305}. # SUPFAM SSF51445 SSF51445 # eggNOG COG2723 LUCA # eggNOG ENOG4105CS2 Bacteria BLAST swissprot:BGLB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BGLB_ECOLI BioCyc ECOL316407:JW3699-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3699-MONOMER BioCyc EcoCyc:EG10114-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10114-MONOMER BioCyc MetaCyc:EG10114-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10114-MONOMER COG COG2723 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2723 DIP DIP-9214N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9214N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1099/00221287-133-3-563 http://dx.doi.org/10.1099/00221287-133-3-563 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.2.1.86 http://www.genome.jp/dbget-bin/www_bget?EC:3.2.1.86 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M15746 http://www.ebi.ac.uk/ena/data/view/M15746 EMBL M16487 http://www.ebi.ac.uk/ena/data/view/M16487 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.2.1.86 http://enzyme.expasy.org/EC/3.2.1.86 EchoBASE EB0112 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0112 EcoGene EG10114 http://www.ecogene.org/geneInfo.php?eg_id=EG10114 EnsemblBacteria AAC76744 http://www.ensemblgenomes.org/id/AAC76744 EnsemblBacteria AAC76744 http://www.ensemblgenomes.org/id/AAC76744 EnsemblBacteria BAE77567 http://www.ensemblgenomes.org/id/BAE77567 EnsemblBacteria BAE77567 http://www.ensemblgenomes.org/id/BAE77567 EnsemblBacteria BAE77567 http://www.ensemblgenomes.org/id/BAE77567 EnsemblBacteria b3721 http://www.ensemblgenomes.org/id/b3721 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004553 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004553 GO_function GO:0008422 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008422 GO_function GO:0008706 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008706 GO_process GO:0044724 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044724 GO_process GO:1901657 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901657 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 3.20.20.80 http://www.cathdb.info/version/latest/superfamily/3.20.20.80 GeneID 948234 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948234 HOGENOM HOG000088631 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000088631&db=HOGENOM6 InParanoid P11988 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P11988 IntAct P11988 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P11988* IntEnz 3.2.1.86 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.2.1.86 InterPro IPR001360 http://www.ebi.ac.uk/interpro/entry/IPR001360 InterPro IPR013781 http://www.ebi.ac.uk/interpro/entry/IPR013781 InterPro IPR017853 http://www.ebi.ac.uk/interpro/entry/IPR017853 InterPro IPR018120 http://www.ebi.ac.uk/interpro/entry/IPR018120 InterPro IPR033132 http://www.ebi.ac.uk/interpro/entry/IPR033132 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3699 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3699 KEGG_Gene eco:b3721 http://www.genome.jp/dbget-bin/www_bget?eco:b3721 KEGG_Orthology KO:K01223 http://www.genome.jp/dbget-bin/www_bget?KO:K01223 KEGG_Pathway ko00010 http://www.genome.jp/kegg-bin/show_pathway?ko00010 KEGG_Reaction rn:R05134 http://www.genome.jp/dbget-bin/www_bget?rn:R05134 OMA TIDCFER http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TIDCFER PANTHER PTHR10353 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10353 PRINTS PR00131 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00131 PROSITE PS00572 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00572 PROSITE PS00653 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00653 PSORT swissprot:BGLB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BGLB_ECOLI PSORT-B swissprot:BGLB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BGLB_ECOLI PSORT2 swissprot:BGLB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BGLB_ECOLI Pfam PF00232 http://pfam.xfam.org/family/PF00232 Phobius swissprot:BGLB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BGLB_ECOLI PhylomeDB P11988 http://phylomedb.org/?seqid=P11988 ProteinModelPortal P11988 http://www.proteinmodelportal.org/query/uniprot/P11988 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3034860 http://www.ncbi.nlm.nih.gov/pubmed/3034860 PubMed 3309161 http://www.ncbi.nlm.nih.gov/pubmed/3309161 PubMed 4576407 http://www.ncbi.nlm.nih.gov/pubmed/4576407 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418177 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418177 RefSeq WP_000643228 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000643228 SMR P11988 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P11988 STRING 511145.b3721 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3721&targetmode=cogs STRING COG2723 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2723&targetmode=cogs SUPFAM SSF51445 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51445 UniProtKB BGLB_ECOLI http://www.uniprot.org/uniprot/BGLB_ECOLI UniProtKB-AC P11988 http://www.uniprot.org/uniprot/P11988 charge swissprot:BGLB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BGLB_ECOLI eggNOG COG2723 http://eggnogapi.embl.de/nog_data/html/tree/COG2723 eggNOG ENOG4105CS2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CS2 epestfind swissprot:BGLB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BGLB_ECOLI garnier swissprot:BGLB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BGLB_ECOLI helixturnhelix swissprot:BGLB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BGLB_ECOLI hmoment swissprot:BGLB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BGLB_ECOLI iep swissprot:BGLB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BGLB_ECOLI inforesidue swissprot:BGLB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BGLB_ECOLI octanol swissprot:BGLB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BGLB_ECOLI pepcoil swissprot:BGLB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BGLB_ECOLI pepdigest swissprot:BGLB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BGLB_ECOLI pepinfo swissprot:BGLB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BGLB_ECOLI pepnet swissprot:BGLB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BGLB_ECOLI pepstats swissprot:BGLB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BGLB_ECOLI pepwheel swissprot:BGLB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BGLB_ECOLI pepwindow swissprot:BGLB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BGLB_ECOLI sigcleave swissprot:BGLB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BGLB_ECOLI ## Database ID URL or Descriptions # BioGrid 4259122 16 # EcoGene EG12149 asr # FUNCTION ASR_ECOLI Required for growth and/or survival at acidic conditions (pH 4.5). Needed for the adaptation process at pH 4.5 that enables cells to survive at extremely low pH (pH 2.0). {ECO 0000269|PubMed 12670971}. # GO_component GO:0042597 periplasmic space; IDA:EcoCyc. # GO_process GO:0010043 response to zinc ion; IEP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0008150 biological_process # HAMAP MF_00546 Asr # INDUCTION ASR_ECOLI By high environmental acidity. # IntAct P36560 5 # InterPro IPR023497 Acid_shock # Organism ASR_ECOLI Escherichia coli (strain K12) # PATRIC 32118496 VBIEscCol129921_1668 # PIR G64915 G64915 # PTM ASR_ECOLI Proteolytic processing gives rise to the active protein. {ECO 0000269|PubMed 12670971}. # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ASR_ECOLI Acid shock protein # RefSeq NP_416114 NC_000913.3 # SIMILARITY Belongs to the Asr family. {ECO 0000305}. # SUBCELLULAR LOCATION ASR_ECOLI Periplasm. BLAST swissprot:ASR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ASR_ECOLI BioCyc ECOL316407:JW5826-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5826-MONOMER BioCyc EcoCyc:G6855-MONOMER http://biocyc.org/getid?id=EcoCyc:G6855-MONOMER DIP DIP-9183N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9183N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.185.8.2475-2484.2003 http://dx.doi.org/10.1128/JB.185.8.2475-2484.2003 EMBL AF405541 http://www.ebi.ac.uk/ena/data/view/AF405541 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2069 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2069 EcoGene EG12149 http://www.ecogene.org/geneInfo.php?eg_id=EG12149 EnsemblBacteria AAC74669 http://www.ensemblgenomes.org/id/AAC74669 EnsemblBacteria AAC74669 http://www.ensemblgenomes.org/id/AAC74669 EnsemblBacteria BAA15331 http://www.ensemblgenomes.org/id/BAA15331 EnsemblBacteria BAA15331 http://www.ensemblgenomes.org/id/BAA15331 EnsemblBacteria BAA15331 http://www.ensemblgenomes.org/id/BAA15331 EnsemblBacteria b1597 http://www.ensemblgenomes.org/id/b1597 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_process GO:0010043 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010043 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 945103 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945103 HAMAP MF_00546 http://hamap.expasy.org/unirule/MF_00546 IntAct P36560 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P36560* InterPro IPR023497 http://www.ebi.ac.uk/interpro/entry/IPR023497 KEGG_Gene ecj:JW5826 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5826 KEGG_Gene eco:b1597 http://www.genome.jp/dbget-bin/www_bget?eco:b1597 MINT MINT-1320044 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1320044 OMA TTHVKKH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TTHVKKH PSORT swissprot:ASR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ASR_ECOLI PSORT-B swissprot:ASR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ASR_ECOLI PSORT2 swissprot:ASR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ASR_ECOLI Phobius swissprot:ASR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ASR_ECOLI ProteinModelPortal P36560 http://www.proteinmodelportal.org/query/uniprot/P36560 PubMed 10094685 http://www.ncbi.nlm.nih.gov/pubmed/10094685 PubMed 12670971 http://www.ncbi.nlm.nih.gov/pubmed/12670971 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416114 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416114 STRING 511145.b1597 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1597&targetmode=cogs UniProtKB ASR_ECOLI http://www.uniprot.org/uniprot/ASR_ECOLI UniProtKB-AC P36560 http://www.uniprot.org/uniprot/P36560 charge swissprot:ASR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ASR_ECOLI epestfind swissprot:ASR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ASR_ECOLI garnier swissprot:ASR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ASR_ECOLI helixturnhelix swissprot:ASR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ASR_ECOLI hmoment swissprot:ASR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ASR_ECOLI iep swissprot:ASR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ASR_ECOLI inforesidue swissprot:ASR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ASR_ECOLI octanol swissprot:ASR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ASR_ECOLI pepcoil swissprot:ASR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ASR_ECOLI pepdigest swissprot:ASR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ASR_ECOLI pepinfo swissprot:ASR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ASR_ECOLI pepnet swissprot:ASR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ASR_ECOLI pepstats swissprot:ASR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ASR_ECOLI pepwheel swissprot:ASR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ASR_ECOLI pepwindow swissprot:ASR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ASR_ECOLI sigcleave swissprot:ASR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ASR_ECOLI ## Database ID URL or Descriptions # CAUTION There is no equivalent of this gene in strain K12 / MG1655. {ECO 0000305}. # FUNCTION INH18_ECOLI Involved in the transposition of the insertion sequence IS5. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # InterPro IPR002559 Transposase_11 # InterPro IPR008490 Transposase_InsH_N # Organism INH18_ECOLI Escherichia coli (strain K12) # Pfam PF01609 DDE_Tnp_1 # Pfam PF05598 DUF772 # RecName INH18_ECOLI Transposase InsH for insertion sequence element IS5-18 # RefSeq WP_000019403 NZ_LN832404.1 # SIMILARITY Belongs to the transposase 11 family. {ECO 0000305}. # eggNOG COG3039 LUCA # eggNOG ENOG4105F2I Bacteria BLAST swissprot:INH18_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INH18_ECOLI DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EnsemblBacteria BAE78086 http://www.ensemblgenomes.org/id/BAE78086 EnsemblBacteria BAE78086 http://www.ensemblgenomes.org/id/BAE78086 EnsemblBacteria BAE78086 http://www.ensemblgenomes.org/id/BAE78086 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 InterPro IPR002559 http://www.ebi.ac.uk/interpro/entry/IPR002559 InterPro IPR008490 http://www.ebi.ac.uk/interpro/entry/IPR008490 KEGG_Gene ecj:JW5951 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5951 PSORT swissprot:INH18_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INH18_ECOLI PSORT-B swissprot:INH18_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INH18_ECOLI PSORT2 swissprot:INH18_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INH18_ECOLI Pfam PF01609 http://pfam.xfam.org/family/PF01609 Pfam PF05598 http://pfam.xfam.org/family/PF05598 Phobius swissprot:INH18_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INH18_ECOLI PhylomeDB P0CE65 http://phylomedb.org/?seqid=P0CE65 ProteinModelPortal P0CE65 http://www.proteinmodelportal.org/query/uniprot/P0CE65 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 RefSeq WP_000019403 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000019403 SMR P0CE65 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0CE65 STRING 511145.b3505 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3505&targetmode=cogs UniProtKB INH18_ECOLI http://www.uniprot.org/uniprot/INH18_ECOLI UniProtKB-AC P0CE65 http://www.uniprot.org/uniprot/P0CE65 charge swissprot:INH18_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INH18_ECOLI eggNOG COG3039 http://eggnogapi.embl.de/nog_data/html/tree/COG3039 eggNOG ENOG4105F2I http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F2I epestfind swissprot:INH18_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INH18_ECOLI garnier swissprot:INH18_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INH18_ECOLI helixturnhelix swissprot:INH18_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INH18_ECOLI hmoment swissprot:INH18_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INH18_ECOLI iep swissprot:INH18_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INH18_ECOLI inforesidue swissprot:INH18_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INH18_ECOLI octanol swissprot:INH18_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INH18_ECOLI pepcoil swissprot:INH18_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INH18_ECOLI pepdigest swissprot:INH18_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INH18_ECOLI pepinfo swissprot:INH18_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INH18_ECOLI pepnet swissprot:INH18_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INH18_ECOLI pepstats swissprot:INH18_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INH18_ECOLI pepwheel swissprot:INH18_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INH18_ECOLI pepwindow swissprot:INH18_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INH18_ECOLI sigcleave swissprot:INH18_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INH18_ECOLI ## Database ID URL or Descriptions # AltName RPOE_ECOLI RNA polymerase sigma-E factor # AltName RPOE_ECOLI Sigma-24 # BioGrid 4263046 221 # DISRUPTION PHENOTYPE RPOE_ECOLI Reduced viability at 37 degrees Celsius, death at 42 degrees Celsius (PubMed 7889935). Loss of transcription from rpoE-dependent promoters (PubMed 7889935). Increased sensitivity to outer membrane disruption (PubMed 7889934). {ECO 0000269|PubMed 7889934, ECO 0000269|PubMed 7889935}. # DOMAIN RPOE_ECOLI The sigma-70 factor domain-2 mediates sequence-specific interaction with the -10 element in promoter DNA, and plays an important role in melting the double-stranded DNA and the formation of the transcription bubble. The sigma-70 factor domain- 2 mediates interaction with the RNA polymerase subunits RpoB and RpoC. {ECO 0000269|PubMed 12016219}. # DOMAIN RPOE_ECOLI The sigma-70 factor domain-4 contains a helix-turn-helix (H-T-H) motif that mediates interaction with the -35 element in promoter DNA. The domain also mediates interaction with the RNA polymerase subunit RpoA. Interactions between sigma-70 factor domain-4 and anti-sigma factors prevents interaction of sigma factors with the RNA polymerase catalytic core. {ECO 0000269|PubMed 12016219, ECO 0000269|PubMed 16903784}. # ENZYME REGULATION RPOE_ECOLI ECF sigma-E is held in an inactive form by its cognate anti-sigma factor (RseA) until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal (periplasmic stress and excess LPS) triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The anti-sigma factor RseA is an inner membrane protein, binding sigma-E in the cytoplasm and RseB in the periplasm. RseA is first cut extracytoplasmically (site-1 protease, S1P, by DegS), then within the membrane itself (site-2 protease, S2P, by RseP), while cytoplasmic proteases (predominantly ClpX-ClpP) finish degrading the regulatory protein, liberating sigma-E (PubMed 15371343). Degradation of RseA requires 2 signals to activate DegS; an outer membrane protein (OMP) signal activates DegS, while an LPS signal causes release of RseB from RseA, freeing RseA to be cleaved (PubMed 23687042). The rate- limiting step in this protease cascade is the first signal-sensing cleavage (half-life about 1 minute) (PubMed 17210793). {ECO 0000269|PubMed 15371343, ECO 0000269|PubMed 17210793, ECO 0000269|PubMed 23687042, ECO 0000269|PubMed 9159522}. # EcoGene EG11897 rpoE # FUNCTION RPOE_ECOLI Sigma factors are initiation factors that promote the attachment of RNA polymerase (RNAP) to specific initiation sites and are then released (PubMed 7889935, PubMed 2691330, PubMed 9159522, PubMed 9159523). Extracytoplasmic function (ECF) sigma-E controls the envelope stress response, responding to periplasmic protein stress, increased levels of periplasmic lipopolysaccharide (LPS) as well as heat shock (PubMed 7889935) and oxidative stress; it controls protein processing in the extracytoplasmic compartment. The 90 member regulon consists of the genes necessary for the synthesis and maintenance of both proteins and LPS of the outer membrane (PubMed 7889934, PubMed 11274153, PubMed 16336047). {ECO 0000269|PubMed 11274153, ECO 0000269|PubMed 16336047, ECO 0000269|PubMed 2691330, ECO 0000269|PubMed 7889934, ECO 0000269|PubMed 7889935, ECO 0000269|PubMed 9159522, ECO 0000269|PubMed 9159523}. # GO_component GO:0005737 cytoplasm; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_function GO:0016987 sigma factor activity; IEA:UniProtKB-KW. # GO_process GO:0006352 DNA-templated transcription, initiation; IEA:InterPro. # GO_process GO:0006355 regulation of transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0006970 response to osmotic stress; IDA:EcoCyc. # GO_process GO:0009266 response to temperature stimulus; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0000988 transcription factor activity, protein binding # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # INDUCTION RPOE_ECOLI Induced after shifting to 50 degrees Celsius (PubMed 2691330) (at protein level), when the level of outer membrane proteins (OMP) increases (PubMed 8276244) (at protein level, PubMed 10500101), as periplasmic levels of LPS levels increase (PubMed 23687042) and by some misfolded periplasmic proteins (PubMed 9351822). Positively autoregulated (via promoter P2) (PubMed 7889935), slightly induced by elevated temperatures (PubMed 7889934). Transiently induced by cold shock in a PNPase- dependent fashion (PubMed 14527658). Part of the rpoE-rseA-rseB- rseC operon (PubMed 9159522, PubMed 9159523). {ECO 0000269|PubMed 10500101, ECO 0000269|PubMed 14527658, ECO 0000269|PubMed 23687042, ECO 0000269|PubMed 2691330, ECO 0000269|PubMed 7889934, ECO 0000269|PubMed 7889935, ECO 0000269|PubMed 8276244, ECO 0000269|PubMed 9159522, ECO 0000269|PubMed 9159523, ECO 0000269|PubMed 9351822}. # INTERACTION RPOE_ECOLI Q46864 mqsA; NbExp=2; IntAct=EBI-1129580, EBI-1120353; # IntAct P0AGB6 30 # InterPro IPR000838 RNA_pol_sigma70_ECF_CS # InterPro IPR007627 RNA_pol_sigma70_r2 # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR013249 RNA_pol_sigma70_r4_t2 # InterPro IPR013324 RNA_pol_sigma_r3_r4 # InterPro IPR013325 RNA_pol_sigma_r2 # InterPro IPR014284 RNA_pol_sigma-70_dom # InterPro IPR014286 RNA_pol_sigma70_RpoE # KEGG_Brite ko03021 Transcription machinery # Organism RPOE_ECOLI Escherichia coli (strain K12) # PATRIC 32120545 VBIEscCol129921_2675 # PDB 1OR7 X-ray; 2.00 A; A/B=1-191 # PDB 2H27 X-ray; 2.30 A; A/D=122-191 # PIR I60227 I60227 # PROSITE PS01063 SIGMA70_ECF # Pfam PF04542 Sigma70_r2 # Pfam PF08281 Sigma70_r4_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RPOE_ECOLI ECF RNA polymerase sigma-E factor # RefSeq NP_417068 NC_000913.3 # RefSeq WP_001295364 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA10920.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the sigma-70 factor family. ECF subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION RPOE_ECOLI Cytoplasm {ECO 0000269|PubMed 11777003, ECO 0000269|PubMed 9159522}. Note=Associates with the inner membrane via RseA (PubMed 9159522, PubMed 11777003). {ECO 0000269|PubMed 11777003}. # SUBUNIT RPOE_ECOLI Interacts transiently with the RNAP catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNAP holoenzyme that can initiate transcription (PubMed 12016219, PubMed 12718891, PubMed 7889935, PubMed 2691330). Interacts 1 1 with anti-sigma-E factor RseA which prevents binding to RNAP catalytic core (PubMed 9159522, PubMed 9159523, PubMed 11777003, PubMed 12016219, PubMed 15371343, PubMed 12718891). An N-terminal (residues 1-108) RseA sigma-E complex also interacts with SspB. {ECO 0000269|PubMed 11777003, ECO 0000269|PubMed 12016219, ECO 0000269|PubMed 12718891, ECO 0000269|PubMed 15371343, ECO 0000269|PubMed 16903784, ECO 0000269|PubMed 2691330, ECO 0000269|PubMed 9159522, ECO 0000269|PubMed 9159523}. # SUPFAM SSF88659 SSF88659 # SUPFAM SSF88946 SSF88946 # TIGRFAMs TIGR02937 sigma70-ECF # TIGRFAMs TIGR02939 RpoE_Sigma70 # eggNOG COG1595 LUCA # eggNOG ENOG4105EMN Bacteria BLAST swissprot:RPOE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RPOE_ECOLI BioCyc ECOL316407:JW2557-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2557-MONOMER BioCyc EcoCyc:RPOE-MONOMER http://biocyc.org/getid?id=EcoCyc:RPOE-MONOMER BioCyc MetaCyc:RPOE-MONOMER http://biocyc.org/getid?id=MetaCyc:RPOE-MONOMER COG COG1595 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1595 DIP DIP-10774N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10774N DOI 10.1016/S0923-2508(03)00167-0 http://dx.doi.org/10.1016/S0923-2508(03)00167-0 DOI 10.1016/S1097-2765(03)00148-5 http://dx.doi.org/10.1016/S1097-2765(03)00148-5 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1997.3601713.x http://dx.doi.org/10.1046/j.1365-2958.1997.3601713.x DOI 10.1046/j.1365-2958.1997.3611718.x http://dx.doi.org/10.1046/j.1365-2958.1997.3611718.x DOI 10.1073/pnas.91.16.7573 http://dx.doi.org/10.1073/pnas.91.16.7573 DOI 10.1074/jbc.M006214200 http://dx.doi.org/10.1074/jbc.M006214200 DOI 10.1074/jbc.M100464200 http://dx.doi.org/10.1074/jbc.M100464200 DOI 10.1074/jbc.M202881200 http://dx.doi.org/10.1074/jbc.M202881200 DOI 10.1093/emboj/16.21.6394 http://dx.doi.org/10.1093/emboj/16.21.6394 DOI 10.1101/gad.1240104 http://dx.doi.org/10.1101/gad.1240104 DOI 10.1101/gad.13.18.2449 http://dx.doi.org/10.1101/gad.13.18.2449 DOI 10.1101/gad.1496707 http://dx.doi.org/10.1101/gad.1496707 DOI 10.1101/gad.3.9.1462 http://dx.doi.org/10.1101/gad.3.9.1462 DOI 10.1101/gad.7.12b.2618 http://dx.doi.org/10.1101/gad.7.12b.2618 DOI 10.1126/science.1235358 http://dx.doi.org/10.1126/science.1235358 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pbio.0040002 http://dx.doi.org/10.1371/journal.pbio.0040002 DOI 10.1371/journal.pbio.0040269 http://dx.doi.org/10.1371/journal.pbio.0040269 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D13169 http://www.ebi.ac.uk/ena/data/view/D13169 EMBL D64044 http://www.ebi.ac.uk/ena/data/view/D64044 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U10148 http://www.ebi.ac.uk/ena/data/view/U10148 EMBL U37089 http://www.ebi.ac.uk/ena/data/view/U37089 EchoBASE EB1843 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1843 EcoGene EG11897 http://www.ecogene.org/geneInfo.php?eg_id=EG11897 EnsemblBacteria AAC75626 http://www.ensemblgenomes.org/id/AAC75626 EnsemblBacteria AAC75626 http://www.ensemblgenomes.org/id/AAC75626 EnsemblBacteria BAE76749 http://www.ensemblgenomes.org/id/BAE76749 EnsemblBacteria BAE76749 http://www.ensemblgenomes.org/id/BAE76749 EnsemblBacteria BAE76749 http://www.ensemblgenomes.org/id/BAE76749 EnsemblBacteria b2573 http://www.ensemblgenomes.org/id/b2573 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0016987 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016987 GO_process GO:0006352 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006352 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0006970 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006970 GO_process GO:0009266 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009266 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0000988 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000988 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 947050 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947050 HOGENOM HOG000094755 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000094755&db=HOGENOM6 InParanoid P0AGB6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGB6 IntAct P0AGB6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AGB6* InterPro IPR000838 http://www.ebi.ac.uk/interpro/entry/IPR000838 InterPro IPR007627 http://www.ebi.ac.uk/interpro/entry/IPR007627 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR013249 http://www.ebi.ac.uk/interpro/entry/IPR013249 InterPro IPR013324 http://www.ebi.ac.uk/interpro/entry/IPR013324 InterPro IPR013325 http://www.ebi.ac.uk/interpro/entry/IPR013325 InterPro IPR014284 http://www.ebi.ac.uk/interpro/entry/IPR014284 InterPro IPR014286 http://www.ebi.ac.uk/interpro/entry/IPR014286 KEGG_Brite ko03021 http://www.genome.jp/dbget-bin/www_bget?ko03021 KEGG_Gene ecj:JW2557 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2557 KEGG_Gene eco:b2573 http://www.genome.jp/dbget-bin/www_bget?eco:b2573 KEGG_Orthology KO:K03088 http://www.genome.jp/dbget-bin/www_bget?KO:K03088 OMA KYQHKVA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KYQHKVA PDB 1OR7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1OR7 PDB 2H27 http://www.ebi.ac.uk/pdbe-srv/view/entry/2H27 PDBsum 1OR7 http://www.ebi.ac.uk/pdbsum/1OR7 PDBsum 2H27 http://www.ebi.ac.uk/pdbsum/2H27 PROSITE PS01063 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01063 PSORT swissprot:RPOE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RPOE_ECOLI PSORT-B swissprot:RPOE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RPOE_ECOLI PSORT2 swissprot:RPOE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RPOE_ECOLI Pfam PF04542 http://pfam.xfam.org/family/PF04542 Pfam PF08281 http://pfam.xfam.org/family/PF08281 Phobius swissprot:RPOE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RPOE_ECOLI PhylomeDB P0AGB6 http://phylomedb.org/?seqid=P0AGB6 ProteinModelPortal P0AGB6 http://www.proteinmodelportal.org/query/uniprot/P0AGB6 PubMed 10500101 http://www.ncbi.nlm.nih.gov/pubmed/10500101 PubMed 11274153 http://www.ncbi.nlm.nih.gov/pubmed/11274153 PubMed 11777003 http://www.ncbi.nlm.nih.gov/pubmed/11777003 PubMed 12016219 http://www.ncbi.nlm.nih.gov/pubmed/12016219 PubMed 12718891 http://www.ncbi.nlm.nih.gov/pubmed/12718891 PubMed 14527658 http://www.ncbi.nlm.nih.gov/pubmed/14527658 PubMed 15371343 http://www.ncbi.nlm.nih.gov/pubmed/15371343 PubMed 16336047 http://www.ncbi.nlm.nih.gov/pubmed/16336047 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16903784 http://www.ncbi.nlm.nih.gov/pubmed/16903784 PubMed 17210793 http://www.ncbi.nlm.nih.gov/pubmed/17210793 PubMed 23687042 http://www.ncbi.nlm.nih.gov/pubmed/23687042 PubMed 2691330 http://www.ncbi.nlm.nih.gov/pubmed/2691330 PubMed 7768826 http://www.ncbi.nlm.nih.gov/pubmed/7768826 PubMed 7889934 http://www.ncbi.nlm.nih.gov/pubmed/7889934 PubMed 7889935 http://www.ncbi.nlm.nih.gov/pubmed/7889935 PubMed 7961422 http://www.ncbi.nlm.nih.gov/pubmed/7961422 PubMed 8052622 http://www.ncbi.nlm.nih.gov/pubmed/8052622 PubMed 8276244 http://www.ncbi.nlm.nih.gov/pubmed/8276244 PubMed 9159522 http://www.ncbi.nlm.nih.gov/pubmed/9159522 PubMed 9159523 http://www.ncbi.nlm.nih.gov/pubmed/9159523 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9351822 http://www.ncbi.nlm.nih.gov/pubmed/9351822 RefSeq NP_417068 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417068 RefSeq WP_001295364 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295364 SMR P0AGB6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AGB6 STRING 511145.b2573 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2573&targetmode=cogs STRING COG1595 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1595&targetmode=cogs SUPFAM SSF88659 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF88659 SUPFAM SSF88946 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF88946 TIGRFAMs TIGR02937 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02937 TIGRFAMs TIGR02939 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02939 UniProtKB RPOE_ECOLI http://www.uniprot.org/uniprot/RPOE_ECOLI UniProtKB-AC P0AGB6 http://www.uniprot.org/uniprot/P0AGB6 charge swissprot:RPOE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RPOE_ECOLI eggNOG COG1595 http://eggnogapi.embl.de/nog_data/html/tree/COG1595 eggNOG ENOG4105EMN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EMN epestfind swissprot:RPOE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RPOE_ECOLI garnier swissprot:RPOE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RPOE_ECOLI helixturnhelix swissprot:RPOE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RPOE_ECOLI hmoment swissprot:RPOE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RPOE_ECOLI iep swissprot:RPOE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RPOE_ECOLI inforesidue swissprot:RPOE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RPOE_ECOLI octanol swissprot:RPOE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RPOE_ECOLI pepcoil swissprot:RPOE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RPOE_ECOLI pepdigest swissprot:RPOE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RPOE_ECOLI pepinfo swissprot:RPOE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RPOE_ECOLI pepnet swissprot:RPOE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RPOE_ECOLI pepstats swissprot:RPOE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RPOE_ECOLI pepwheel swissprot:RPOE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RPOE_ECOLI pepwindow swissprot:RPOE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RPOE_ECOLI sigcleave swissprot:RPOE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RPOE_ECOLI ## Database ID URL or Descriptions # FUNCTION INSF7_ECOLI Involved in the transposition of the insertion sequence IS3. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006310 DNA recombination; IEA:UniProtKB-KW. # GO_process GO:0015074 DNA integration; IEA:InterPro. # GO_process GO:0032196 transposition; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 3.30.420.10 -; 1. # InterPro IPR001584 Integrase_cat-core # InterPro IPR012337 RNaseH-like_dom # InterPro IPR025948 HTH-like_dom # Organism INSF7_ECOLI Escherichia coli (strain K12) # PROSITE PS50994 INTEGRASE # Pfam PF00665 rve # Pfam PF13276 HTH_21 # RecName INSF7_ECOLI Transposase InsF for insertion sequence IS3fB # RefSeq NP_061396 NC_002483.1 # RefSeq WP_001443048 NZ_CP014273.1 # SIMILARITY Belongs to the transposase IS3/IS150/IS904 family. {ECO 0000305}. # SIMILARITY Contains 1 integrase catalytic domain. {ECO:0000255|PROSITE-ProRule PRU00457}. # SUPFAM SSF53098 SSF53098 # eggNOG COG2801 LUCA BLAST swissprot:INSF7_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSF7_ECOLI EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0015074 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015074 GO_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 3.30.420.10 http://www.cathdb.info/version/latest/superfamily/3.30.420.10 GeneID 1263538 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263538 InterPro IPR001584 http://www.ebi.ac.uk/interpro/entry/IPR001584 InterPro IPR012337 http://www.ebi.ac.uk/interpro/entry/IPR012337 InterPro IPR025948 http://www.ebi.ac.uk/interpro/entry/IPR025948 OMA WSMDTRM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WSMDTRM PROSITE PS50994 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50994 PSORT swissprot:INSF7_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSF7_ECOLI PSORT-B swissprot:INSF7_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSF7_ECOLI PSORT2 swissprot:INSF7_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSF7_ECOLI Pfam PF00665 http://pfam.xfam.org/family/PF00665 Pfam PF13276 http://pfam.xfam.org/family/PF13276 Phobius swissprot:INSF7_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSF7_ECOLI PhylomeDB Q9JMT3 http://phylomedb.org/?seqid=Q9JMT3 ProteinModelPortal Q9JMT3 http://www.proteinmodelportal.org/query/uniprot/Q9JMT3 RefSeq NP_061396 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061396 RefSeq WP_001443048 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001443048 SMR Q9JMT3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9JMT3 STRING 511145.b2089 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2089&targetmode=cogs SUPFAM SSF53098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098 UniProtKB INSF7_ECOLI http://www.uniprot.org/uniprot/INSF7_ECOLI UniProtKB-AC Q9JMT3 http://www.uniprot.org/uniprot/Q9JMT3 charge swissprot:INSF7_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSF7_ECOLI eggNOG COG2801 http://eggnogapi.embl.de/nog_data/html/tree/COG2801 epestfind swissprot:INSF7_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSF7_ECOLI garnier swissprot:INSF7_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSF7_ECOLI helixturnhelix swissprot:INSF7_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSF7_ECOLI hmoment swissprot:INSF7_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSF7_ECOLI iep swissprot:INSF7_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSF7_ECOLI inforesidue swissprot:INSF7_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSF7_ECOLI octanol swissprot:INSF7_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSF7_ECOLI pepcoil swissprot:INSF7_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSF7_ECOLI pepdigest swissprot:INSF7_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSF7_ECOLI pepinfo swissprot:INSF7_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSF7_ECOLI pepnet swissprot:INSF7_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSF7_ECOLI pepstats swissprot:INSF7_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSF7_ECOLI pepwheel swissprot:INSF7_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSF7_ECOLI pepwindow swissprot:INSF7_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSF7_ECOLI sigcleave swissprot:INSF7_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSF7_ECOLI ## Database ID URL or Descriptions # AltName FUCM_ECOLI Fucose 1-epimerase # AltName FUCM_ECOLI Type-2 mutarotase # BRENDA 5.1.3.29 2026 # BioGrid 4262305 16 # CATALYTIC ACTIVITY FUCM_ECOLI Alpha-L-fucose = beta-L-fucose. # EcoGene EG10355 fucU # FUNCTION FUCM_ECOLI Involved in the anomeric conversion of L-fucose. It also exhibits a pyranase activity for D-ribose. {ECO 0000269|PubMed 15060078}. # GO_component GO:0005737 cytoplasm; ISS:EcoCyc. # GO_function GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives; IDA:EcoCyc. # GO_function GO:0042806 fucose binding; IDA:MGI. # GO_process GO:0042354 L-fucose metabolic process; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.1650.10 -; 1. # HAMAP MF_01662 L_fucose_rotase # IntAct P0AEN8 5 # InterPro IPR007721 RbsD_FucU # InterPro IPR023750 RbsD-like # InterPro IPR023751 L-fucose_mutarotase # KEGG_Brite ko01000 Enzymes # Organism FUCM_ECOLI Escherichia coli (strain K12) # PATHWAY FUCM_ECOLI Carbohydrate metabolism; L-fucose metabolism. # PATRIC 32121024 VBIEscCol129921_2904 # PDB 2WCV X-ray; 1.90 A; A/B/C/D/E/F/G/H/I/J=1-140 # PIR H65062 Q4ECKR # Pfam PF05025 RbsD_FucU # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FUCM_ECOLI L-fucose mutarotase # RefSeq NP_417284 NC_000913.3 # RefSeq WP_000920840 NZ_LN832404.1 # SIMILARITY Belongs to the RbsD / FucU family. FucU mutarotase subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION FUCM_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Homodecamer. {ECO:0000269|PubMed 12738765}. # SUPFAM SSF102546 SSF102546 # eggNOG COG4154 LUCA # eggNOG ENOG4105NWF Bacteria BLAST swissprot:FUCM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FUCM_ECOLI BioCyc ECOL316407:JW2775-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2775-MONOMER BioCyc EcoCyc:EG10355-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10355-MONOMER BioCyc MetaCyc:EG10355-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10355-MONOMER COG COG1869 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1869 DIP DIP-47990N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47990N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M304523200 http://dx.doi.org/10.1074/jbc.M304523200 DOI 10.1074/jbc.M402016200 http://dx.doi.org/10.1074/jbc.M402016200 DOI 10.1093/nar/17.12.4883 http://dx.doi.org/10.1093/nar/17.12.4883 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.1.3.29 http://www.genome.jp/dbget-bin/www_bget?EC:5.1.3.29 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 EMBL X15025 http://www.ebi.ac.uk/ena/data/view/X15025 ENZYME 5.1.3.29 http://enzyme.expasy.org/EC/5.1.3.29 EchoBASE EB0350 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0350 EcoGene EG10355 http://www.ecogene.org/geneInfo.php?eg_id=EG10355 EnsemblBacteria AAC75846 http://www.ensemblgenomes.org/id/AAC75846 EnsemblBacteria AAC75846 http://www.ensemblgenomes.org/id/AAC75846 EnsemblBacteria BAE76876 http://www.ensemblgenomes.org/id/BAE76876 EnsemblBacteria BAE76876 http://www.ensemblgenomes.org/id/BAE76876 EnsemblBacteria BAE76876 http://www.ensemblgenomes.org/id/BAE76876 EnsemblBacteria b2804 http://www.ensemblgenomes.org/id/b2804 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0016857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016857 GO_function GO:0042806 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042806 GO_process GO:0042354 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042354 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.1650.10 http://www.cathdb.info/version/latest/superfamily/3.40.1650.10 GeneID 945842 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945842 HAMAP MF_01662 http://hamap.expasy.org/unirule/MF_01662 HOGENOM HOG000219041 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219041&db=HOGENOM6 InParanoid P0AEN8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEN8 IntAct P0AEN8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEN8* IntEnz 5.1.3.29 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.1.3.29 InterPro IPR007721 http://www.ebi.ac.uk/interpro/entry/IPR007721 InterPro IPR023750 http://www.ebi.ac.uk/interpro/entry/IPR023750 InterPro IPR023751 http://www.ebi.ac.uk/interpro/entry/IPR023751 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2775 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2775 KEGG_Gene eco:b2804 http://www.genome.jp/dbget-bin/www_bget?eco:b2804 KEGG_Orthology KO:K02431 http://www.genome.jp/dbget-bin/www_bget?KO:K02431 MINT MINT-1243432 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1243432 OMA ADLNFPA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ADLNFPA PDB 2WCV http://www.ebi.ac.uk/pdbe-srv/view/entry/2WCV PDBsum 2WCV http://www.ebi.ac.uk/pdbsum/2WCV PSORT swissprot:FUCM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FUCM_ECOLI PSORT-B swissprot:FUCM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FUCM_ECOLI PSORT2 swissprot:FUCM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FUCM_ECOLI Pfam PF05025 http://pfam.xfam.org/family/PF05025 Phobius swissprot:FUCM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FUCM_ECOLI PhylomeDB P0AEN8 http://phylomedb.org/?seqid=P0AEN8 ProteinModelPortal P0AEN8 http://www.proteinmodelportal.org/query/uniprot/P0AEN8 PubMed 12738765 http://www.ncbi.nlm.nih.gov/pubmed/12738765 PubMed 15060078 http://www.ncbi.nlm.nih.gov/pubmed/15060078 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2664711 http://www.ncbi.nlm.nih.gov/pubmed/2664711 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417284 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417284 RefSeq WP_000920840 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000920840 SMR P0AEN8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEN8 STRING 511145.b2804 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2804&targetmode=cogs STRING COG1869 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1869&targetmode=cogs SUPFAM SSF102546 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF102546 UniProtKB FUCM_ECOLI http://www.uniprot.org/uniprot/FUCM_ECOLI UniProtKB-AC P0AEN8 http://www.uniprot.org/uniprot/P0AEN8 charge swissprot:FUCM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FUCM_ECOLI eggNOG COG4154 http://eggnogapi.embl.de/nog_data/html/tree/COG4154 eggNOG ENOG4105NWF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105NWF epestfind swissprot:FUCM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FUCM_ECOLI garnier swissprot:FUCM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FUCM_ECOLI helixturnhelix swissprot:FUCM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FUCM_ECOLI hmoment swissprot:FUCM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FUCM_ECOLI iep swissprot:FUCM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FUCM_ECOLI inforesidue swissprot:FUCM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FUCM_ECOLI octanol swissprot:FUCM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FUCM_ECOLI pepcoil swissprot:FUCM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FUCM_ECOLI pepdigest swissprot:FUCM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FUCM_ECOLI pepinfo swissprot:FUCM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FUCM_ECOLI pepnet swissprot:FUCM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FUCM_ECOLI pepstats swissprot:FUCM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FUCM_ECOLI pepwheel swissprot:FUCM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FUCM_ECOLI pepwindow swissprot:FUCM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FUCM_ECOLI sigcleave swissprot:FUCM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FUCM_ECOLI ## Database ID URL or Descriptions # BRENDA 1.8.1 2026 # BioGrid 4261715 36 # CATALYTIC ACTIVITY TRXB_ECOLI Thioredoxin + NADP(+) = thioredoxin disulfide + NADPH. # COFACTOR TRXB_ECOLI Name=FAD; Xref=ChEBI CHEBI 57692; Evidence={ECO 0000269|PubMed 8114095}; Note=Binds 1 FAD per subunit. {ECO 0000269|PubMed 8114095}; # DrugBank DB03147 Flavin adenine dinucleotide # EcoGene EG11032 trxB # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004791 thioredoxin-disulfide reductase activity; IDA:CACAO. # GO_function GO:0050660 flavin adenine dinucleotide binding; IDA:EcoCyc. # GO_process GO:0019430 removal of superoxide radicals; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # Gene3D 3.50.50.60 -; 2. # INTERACTION TRXB_ECOLI P0AA25 trxA; NbExp=2; IntAct=EBI-1029826, EBI-368542; # IntAct P0A9P4 15 # InterPro IPR000103 Pyridine_nuc-diS_OxRdtase_2 # InterPro IPR005982 Thioredox_Rdtase # InterPro IPR008255 Pyr_nucl-diS_OxRdtase_2_AS # InterPro IPR023753 FAD/NAD-binding_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00240 Pyrimidine metabolism # KEGG_Pathway ko00450 Selenocompound metabolism # MISCELLANEOUS TRXB_ECOLI The active site is a redox-active disulfide bond. # Organism TRXB_ECOLI Escherichia coli (strain K12) # PATRIC 32116985 VBIEscCol129921_0917 # PDB 1CL0 X-ray; 2.50 A; A=2-321 # PDB 1F6M X-ray; 2.95 A; A/B/E/F=2-321 # PDB 1TDE X-ray; 2.10 A; A=2-317 # PDB 1TDF X-ray; 2.30 A; A=2-317 # PDB 1TRB X-ray; 2.00 A; A=2-321 # PIR A28074 RDECT # PRINTS PR00469 PNDRDTASEII # PROSITE PS00573 PYRIDINE_REDOX_2 # Pfam PF07992 Pyr_redox_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TRXB_ECOLI Thioredoxin reductase # RefSeq NP_415408 NC_000913.3 # RefSeq WP_000537418 NZ_LN832404.1 # SIMILARITY Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family. {ECO 0000305}. # SUBCELLULAR LOCATION TRXB_ECOLI Cytoplasm. # SUBUNIT Homodimer. {ECO:0000269|PubMed 10947986}. # SUPFAM SSF51905 SSF51905 # TIGRFAMs TIGR01292 TRX_reduct # eggNOG COG0492 LUCA # eggNOG ENOG4105C3M Bacteria BLAST swissprot:TRXB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRXB_ECOLI BioCyc ECOL316407:JW0871-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0871-MONOMER BioCyc EcoCyc:THIOREDOXIN-REDUCT-NADPH-MONOMER http://biocyc.org/getid?id=EcoCyc:THIOREDOXIN-REDUCT-NADPH-MONOMER BioCyc MetaCyc:THIOREDOXIN-REDUCT-NADPH-MONOMER http://biocyc.org/getid?id=MetaCyc:THIOREDOXIN-REDUCT-NADPH-MONOMER COG COG0492 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0492 DIP DIP-6168N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-6168N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/jmbi.1994.1190 http://dx.doi.org/10.1006/jmbi.1994.1190 DOI 10.1016/0006-291X(92)90636-Y http://dx.doi.org/10.1016/0006-291X(92)90636-Y DOI 10.1038/352172a0 http://dx.doi.org/10.1038/352172a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1110/ps.8.11.2366 http://dx.doi.org/10.1110/ps.8.11.2366 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1126/science.289.5482.1190 http://dx.doi.org/10.1126/science.289.5482.1190 DrugBank DB03147 http://www.drugbank.ca/drugs/DB03147 EC_number EC:1.8.1.9 http://www.genome.jp/dbget-bin/www_bget?EC:1.8.1.9 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J03762 http://www.ebi.ac.uk/ena/data/view/J03762 EMBL L21749 http://www.ebi.ac.uk/ena/data/view/L21749 EMBL M95935 http://www.ebi.ac.uk/ena/data/view/M95935 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.8.1.9 http://enzyme.expasy.org/EC/1.8.1.9 EchoBASE EB1025 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1025 EcoGene EG11032 http://www.ecogene.org/geneInfo.php?eg_id=EG11032 EnsemblBacteria AAC73974 http://www.ensemblgenomes.org/id/AAC73974 EnsemblBacteria AAC73974 http://www.ensemblgenomes.org/id/AAC73974 EnsemblBacteria BAA35613 http://www.ensemblgenomes.org/id/BAA35613 EnsemblBacteria BAA35613 http://www.ensemblgenomes.org/id/BAA35613 EnsemblBacteria BAA35613 http://www.ensemblgenomes.org/id/BAA35613 EnsemblBacteria b0888 http://www.ensemblgenomes.org/id/b0888 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004791 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_process GO:0019430 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019430 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 GeneID 949054 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949054 HOGENOM HOG000072912 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000072912&db=HOGENOM6 InParanoid P0A9P4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9P4 IntAct P0A9P4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9P4* IntEnz 1.8.1.9 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.8.1.9 InterPro IPR000103 http://www.ebi.ac.uk/interpro/entry/IPR000103 InterPro IPR005982 http://www.ebi.ac.uk/interpro/entry/IPR005982 InterPro IPR008255 http://www.ebi.ac.uk/interpro/entry/IPR008255 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0871 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0871 KEGG_Gene eco:b0888 http://www.genome.jp/dbget-bin/www_bget?eco:b0888 KEGG_Orthology KO:K00384 http://www.genome.jp/dbget-bin/www_bget?KO:K00384 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Pathway ko00450 http://www.genome.jp/kegg-bin/show_pathway?ko00450 KEGG_Reaction rn:R02016 http://www.genome.jp/dbget-bin/www_bget?rn:R02016 KEGG_Reaction rn:R03596 http://www.genome.jp/dbget-bin/www_bget?rn:R03596 KEGG_Reaction rn:R09372 http://www.genome.jp/dbget-bin/www_bget?rn:R09372 OMA GQLEMNN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GQLEMNN PDB 1CL0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1CL0 PDB 1F6M http://www.ebi.ac.uk/pdbe-srv/view/entry/1F6M PDB 1TDE http://www.ebi.ac.uk/pdbe-srv/view/entry/1TDE PDB 1TDF http://www.ebi.ac.uk/pdbe-srv/view/entry/1TDF PDB 1TRB http://www.ebi.ac.uk/pdbe-srv/view/entry/1TRB PDBsum 1CL0 http://www.ebi.ac.uk/pdbsum/1CL0 PDBsum 1F6M http://www.ebi.ac.uk/pdbsum/1F6M PDBsum 1TDE http://www.ebi.ac.uk/pdbsum/1TDE PDBsum 1TDF http://www.ebi.ac.uk/pdbsum/1TDF PDBsum 1TRB http://www.ebi.ac.uk/pdbsum/1TRB PRINTS PR00469 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00469 PROSITE PS00573 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00573 PSORT swissprot:TRXB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRXB_ECOLI PSORT-B swissprot:TRXB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRXB_ECOLI PSORT2 swissprot:TRXB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRXB_ECOLI Pfam PF07992 http://pfam.xfam.org/family/PF07992 Phobius swissprot:TRXB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRXB_ECOLI PhylomeDB P0A9P4 http://phylomedb.org/?seqid=P0A9P4 ProteinModelPortal P0A9P4 http://www.proteinmodelportal.org/query/uniprot/P0A9P4 PubMed 10595539 http://www.ncbi.nlm.nih.gov/pubmed/10595539 PubMed 10947986 http://www.ncbi.nlm.nih.gov/pubmed/10947986 PubMed 1575737 http://www.ncbi.nlm.nih.gov/pubmed/1575737 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2067578 http://www.ncbi.nlm.nih.gov/pubmed/2067578 PubMed 3288628 http://www.ncbi.nlm.nih.gov/pubmed/3288628 PubMed 7934832 http://www.ncbi.nlm.nih.gov/pubmed/7934832 PubMed 8114095 http://www.ncbi.nlm.nih.gov/pubmed/8114095 PubMed 8380150 http://www.ncbi.nlm.nih.gov/pubmed/8380150 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_415408 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415408 RefSeq WP_000537418 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000537418 SMR P0A9P4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9P4 STRING 511145.b0888 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0888&targetmode=cogs STRING COG0492 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0492&targetmode=cogs SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 SWISS-2DPAGE P0A9P4 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A9P4 TIGRFAMs TIGR01292 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01292 UniProtKB TRXB_ECOLI http://www.uniprot.org/uniprot/TRXB_ECOLI UniProtKB-AC P0A9P4 http://www.uniprot.org/uniprot/P0A9P4 charge swissprot:TRXB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRXB_ECOLI eggNOG COG0492 http://eggnogapi.embl.de/nog_data/html/tree/COG0492 eggNOG ENOG4105C3M http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C3M epestfind swissprot:TRXB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRXB_ECOLI garnier swissprot:TRXB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRXB_ECOLI helixturnhelix swissprot:TRXB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRXB_ECOLI hmoment swissprot:TRXB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRXB_ECOLI iep swissprot:TRXB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRXB_ECOLI inforesidue swissprot:TRXB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRXB_ECOLI octanol swissprot:TRXB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRXB_ECOLI pepcoil swissprot:TRXB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRXB_ECOLI pepdigest swissprot:TRXB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRXB_ECOLI pepinfo swissprot:TRXB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRXB_ECOLI pepnet swissprot:TRXB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRXB_ECOLI pepstats swissprot:TRXB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRXB_ECOLI pepwheel swissprot:TRXB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRXB_ECOLI pepwindow swissprot:TRXB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRXB_ECOLI sigcleave swissprot:TRXB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRXB_ECOLI ## Database ID URL or Descriptions # BioGrid 4262823 17 # EcoGene EG13638 ybcV # Gene3D 3.30.1810.10 -; 1. # InterPro IPR009833 DUF1398 # MISCELLANEOUS YBCV_ECOLI Encoded by the cryptic lambdoid prophage DLP12. # Organism YBCV_ECOLI Escherichia coli (strain K12) # PATRIC 32116282 VBIEscCol129921_0581 # PIR D64788 D64788 # Pfam PF07166 DUF1398 # ProDom PD021249 DUF1398 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBCV_ECOLI Uncharacterized protein YbcV # RefSeq NP_415090 NC_000913.3 # RefSeq WP_000079503 NZ_CP014272.1 # SEQUENCE CAUTION Sequence=AAB40754.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY To E.coli YcgX and YdfO. {ECO 0000305}. # SUPFAM SSF160419 SSF160419 # eggNOG COG5562 LUCA BLAST swissprot:YBCV_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBCV_ECOLI BioCyc ECOL316407:JW5081-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5081-MONOMER BioCyc EcoCyc:G6313-MONOMER http://biocyc.org/getid?id=EcoCyc:G6313-MONOMER DIP DIP-11339N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11339N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB3402 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3402 EcoGene EG13638 http://www.ecogene.org/geneInfo.php?eg_id=EG13638 EnsemblBacteria AAC73659 http://www.ensemblgenomes.org/id/AAC73659 EnsemblBacteria AAC73659 http://www.ensemblgenomes.org/id/AAC73659 EnsemblBacteria BAE76334 http://www.ensemblgenomes.org/id/BAE76334 EnsemblBacteria BAE76334 http://www.ensemblgenomes.org/id/BAE76334 EnsemblBacteria BAE76334 http://www.ensemblgenomes.org/id/BAE76334 EnsemblBacteria b0558 http://www.ensemblgenomes.org/id/b0558 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.30.1810.10 http://www.cathdb.info/version/latest/superfamily/3.30.1810.10 GeneID 945178 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945178 HOGENOM HOG000119635 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000119635&db=HOGENOM6 InterPro IPR009833 http://www.ebi.ac.uk/interpro/entry/IPR009833 KEGG_Gene ecj:JW5081 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5081 KEGG_Gene eco:b0558 http://www.genome.jp/dbget-bin/www_bget?eco:b0558 OMA LIETSYN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LIETSYN PSORT swissprot:YBCV_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBCV_ECOLI PSORT-B swissprot:YBCV_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBCV_ECOLI PSORT2 swissprot:YBCV_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBCV_ECOLI Pfam PF07166 http://pfam.xfam.org/family/PF07166 Phobius swissprot:YBCV_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBCV_ECOLI PhylomeDB P77598 http://phylomedb.org/?seqid=P77598 ProteinModelPortal P77598 http://www.proteinmodelportal.org/query/uniprot/P77598 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415090 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415090 RefSeq WP_000079503 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000079503 SMR P77598 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77598 STRING 511145.b0558 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0558&targetmode=cogs SUPFAM SSF160419 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF160419 UniProtKB YBCV_ECOLI http://www.uniprot.org/uniprot/YBCV_ECOLI UniProtKB-AC P77598 http://www.uniprot.org/uniprot/P77598 charge swissprot:YBCV_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBCV_ECOLI eggNOG COG5562 http://eggnogapi.embl.de/nog_data/html/tree/COG5562 epestfind swissprot:YBCV_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBCV_ECOLI garnier swissprot:YBCV_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBCV_ECOLI helixturnhelix swissprot:YBCV_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBCV_ECOLI hmoment swissprot:YBCV_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBCV_ECOLI iep swissprot:YBCV_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBCV_ECOLI inforesidue swissprot:YBCV_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBCV_ECOLI octanol swissprot:YBCV_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBCV_ECOLI pepcoil swissprot:YBCV_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBCV_ECOLI pepdigest swissprot:YBCV_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBCV_ECOLI pepinfo swissprot:YBCV_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBCV_ECOLI pepnet swissprot:YBCV_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBCV_ECOLI pepstats swissprot:YBCV_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBCV_ECOLI pepwheel swissprot:YBCV_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBCV_ECOLI pepwindow swissprot:YBCV_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBCV_ECOLI sigcleave swissprot:YBCV_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBCV_ECOLI ## Database ID URL or Descriptions # BioGrid 4260579 13 # EcoGene EG14181 eutA # FUNCTION EUTA_ECOLI May protect the EutBC lyase from inhibition. {ECO 0000250}. # GO_function GO:0030234 enzyme regulator activity; IDA:EcoCyc. # GO_process GO:0030091 protein repair; IDA:EcoCyc. # GO_process GO:0046336 ethanolamine catabolic process; IEA:UniProtKB-UniPathway. # GO_process GO:0051349 positive regulation of lyase activity; IDA:EcoCyc. # GOslim_function GO:0030234 enzyme regulator activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # IntAct P76551 4 # InterPro IPR009377 Ethanolamine_utilisation_EutA # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko00564 Glycerophospholipid metabolism # Organism EUTA_ECOLI Escherichia coli (strain K12) # PATHWAY EUTA_ECOLI Amine and polyamine degradation; ethanolamine degradation. # PATRIC 32120285 VBIEscCol129921_2545 # PIR B65020 B65020 # PIRSF PIRSF012293 EutA # Pfam PF06277 EutA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EUTA_ECOLI Ethanolamine utilization protein EutA # RefSeq NP_416946 NC_000913.3 # RefSeq WP_001097542 NZ_LN832404.1 # eggNOG COG4819 LUCA # eggNOG ENOG4105DYY Bacteria BLAST swissprot:EUTA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EUTA_ECOLI BioCyc ECOL316407:JW2435-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2435-MONOMER BioCyc EcoCyc:G7281-MONOMER http://biocyc.org/getid?id=EcoCyc:G7281-MONOMER DIP DIP-9527N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9527N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3933 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3933 EcoGene EG14181 http://www.ecogene.org/geneInfo.php?eg_id=EG14181 EnsemblBacteria AAC75504 http://www.ensemblgenomes.org/id/AAC75504 EnsemblBacteria AAC75504 http://www.ensemblgenomes.org/id/AAC75504 EnsemblBacteria BAE76716 http://www.ensemblgenomes.org/id/BAE76716 EnsemblBacteria BAE76716 http://www.ensemblgenomes.org/id/BAE76716 EnsemblBacteria BAE76716 http://www.ensemblgenomes.org/id/BAE76716 EnsemblBacteria b2451 http://www.ensemblgenomes.org/id/b2451 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 GO_process GO:0030091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030091 GO_process GO:0046336 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046336 GO_process GO:0051349 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051349 GOslim_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 946937 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946937 HOGENOM HOG000288847 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000288847&db=HOGENOM6 InParanoid P76551 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76551 IntAct P76551 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76551* InterPro IPR009377 http://www.ebi.ac.uk/interpro/entry/IPR009377 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW2435 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2435 KEGG_Gene eco:b2451 http://www.genome.jp/dbget-bin/www_bget?eco:b2451 KEGG_Orthology KO:K04019 http://www.genome.jp/dbget-bin/www_bget?KO:K04019 KEGG_Pathway ko00564 http://www.genome.jp/kegg-bin/show_pathway?ko00564 KEGG_Reaction rn:R00749 http://www.genome.jp/dbget-bin/www_bget?rn:R00749 OMA QQVTEYA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QQVTEYA PSORT swissprot:EUTA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EUTA_ECOLI PSORT-B swissprot:EUTA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EUTA_ECOLI PSORT2 swissprot:EUTA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EUTA_ECOLI Pfam PF06277 http://pfam.xfam.org/family/PF06277 Phobius swissprot:EUTA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EUTA_ECOLI ProteinModelPortal P76551 http://www.proteinmodelportal.org/query/uniprot/P76551 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416946 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416946 RefSeq WP_001097542 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001097542 STRING 511145.b2451 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2451&targetmode=cogs UniProtKB EUTA_ECOLI http://www.uniprot.org/uniprot/EUTA_ECOLI UniProtKB-AC P76551 http://www.uniprot.org/uniprot/P76551 charge swissprot:EUTA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EUTA_ECOLI eggNOG COG4819 http://eggnogapi.embl.de/nog_data/html/tree/COG4819 eggNOG ENOG4105DYY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DYY epestfind swissprot:EUTA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EUTA_ECOLI garnier swissprot:EUTA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EUTA_ECOLI helixturnhelix swissprot:EUTA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EUTA_ECOLI hmoment swissprot:EUTA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EUTA_ECOLI iep swissprot:EUTA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EUTA_ECOLI inforesidue swissprot:EUTA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EUTA_ECOLI octanol swissprot:EUTA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EUTA_ECOLI pepcoil swissprot:EUTA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EUTA_ECOLI pepdigest swissprot:EUTA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EUTA_ECOLI pepinfo swissprot:EUTA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EUTA_ECOLI pepnet swissprot:EUTA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EUTA_ECOLI pepstats swissprot:EUTA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EUTA_ECOLI pepwheel swissprot:EUTA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EUTA_ECOLI pepwindow swissprot:EUTA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EUTA_ECOLI sigcleave swissprot:EUTA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EUTA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261634 107 # EcoGene EG12257 bcsC # FUNCTION BCSC_ECOLI Required for maximal bacterial cellulose synthesis. {ECO 0000250}. # GO_component GO:0019867 outer membrane; IEA:InterPro. # GO_process GO:0030244 cellulose biosynthetic process; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 1.25.40.10 -; 4. # InterPro IPR008410 BCSC_C # InterPro IPR011990 TPR-like_helical_dom # InterPro IPR013026 TPR-contain_dom # InterPro IPR019734 TPR_repeat # MISCELLANEOUS BCSC_ECOLI The genes bscA, bcsB, bcsZ and bcsC are constitutively transcribed but cellulose synthesis occurs only when AdrA, a putative transmembrane protein regulated by AgfD, is expressed. Cellulose production is abolished in E.coli K12. # Organism BCSC_ECOLI Escherichia coli (strain K12) # PATHWAY BCSC_ECOLI Glycan metabolism; bacterial cellulose biosynthesis. # PATRIC 32122526 VBIEscCol129921_3641 # PROSITE PS50005 TPR; 6 # PROSITE PS50293 TPR_REGION; 2 # Pfam PF05420 BCSC_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BCSC_ECOLI Cellulose synthase operon protein C # RefSeq WP_001225124 NZ_LN832404.1 # RefSeq YP_026226 NC_000913.3 # SEQUENCE CAUTION Sequence=AAB18507.1; Type=Frameshift; Positions=11; Evidence={ECO 0000305}; # SIMILARITY Belongs to the AcsC/BcsC family. {ECO 0000305}. # SIMILARITY Contains 9 TPR repeats. {ECO:0000255|PROSITE- ProRule PRU00339}. # SMART SM00028 TPR; 6 # SUPFAM SSF48452 SSF48452; 6 # TCDB 1.B.55.3 the poly acetyl glucosamine porin (pgaa) family # eggNOG COG0457 LUCA # eggNOG ENOG4105EJG Bacteria BLAST swissprot:BCSC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BCSC_ECOLI BioCyc ECOL316407:JW5942-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5942-MONOMER BioCyc EcoCyc:EG12257-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12257-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2001.02337.x http://dx.doi.org/10.1046/j.1365-2958.2001.02337.x DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2166 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2166 EcoGene EG12257 http://www.ecogene.org/geneInfo.php?eg_id=EG12257 EnsemblBacteria AAT48188 http://www.ensemblgenomes.org/id/AAT48188 EnsemblBacteria AAT48188 http://www.ensemblgenomes.org/id/AAT48188 EnsemblBacteria BAE77764 http://www.ensemblgenomes.org/id/BAE77764 EnsemblBacteria BAE77764 http://www.ensemblgenomes.org/id/BAE77764 EnsemblBacteria BAE77764 http://www.ensemblgenomes.org/id/BAE77764 EnsemblBacteria b3530 http://www.ensemblgenomes.org/id/b3530 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0019867 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019867 GO_process GO:0030244 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030244 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 1.25.40.10 http://www.cathdb.info/version/latest/superfamily/1.25.40.10 GeneID 948047 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948047 HOGENOM HOG000125935 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125935&db=HOGENOM6 InParanoid P37650 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37650 InterPro IPR008410 http://www.ebi.ac.uk/interpro/entry/IPR008410 InterPro IPR011990 http://www.ebi.ac.uk/interpro/entry/IPR011990 InterPro IPR013026 http://www.ebi.ac.uk/interpro/entry/IPR013026 InterPro IPR019734 http://www.ebi.ac.uk/interpro/entry/IPR019734 KEGG_Gene ecj:JW5942 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5942 KEGG_Gene eco:b3530 http://www.genome.jp/dbget-bin/www_bget?eco:b3530 PROSITE PS50005 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50005 PROSITE PS50293 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50293 PSORT swissprot:BCSC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BCSC_ECOLI PSORT-B swissprot:BCSC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BCSC_ECOLI PSORT2 swissprot:BCSC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BCSC_ECOLI Pfam PF05420 http://pfam.xfam.org/family/PF05420 Phobius swissprot:BCSC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BCSC_ECOLI ProteinModelPortal P37650 http://www.proteinmodelportal.org/query/uniprot/P37650 PubMed 11260463 http://www.ncbi.nlm.nih.gov/pubmed/11260463 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001225124 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001225124 RefSeq YP_026226 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026226 SMART SM00028 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00028 STRING 511145.b3530 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3530&targetmode=cogs SUPFAM SSF48452 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48452 TCDB 1.B.55.3 http://www.tcdb.org/search/result.php?tc=1.B.55.3 UniProtKB BCSC_ECOLI http://www.uniprot.org/uniprot/BCSC_ECOLI UniProtKB-AC P37650 http://www.uniprot.org/uniprot/P37650 charge swissprot:BCSC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BCSC_ECOLI eggNOG COG0457 http://eggnogapi.embl.de/nog_data/html/tree/COG0457 eggNOG ENOG4105EJG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EJG epestfind swissprot:BCSC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BCSC_ECOLI garnier swissprot:BCSC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BCSC_ECOLI helixturnhelix swissprot:BCSC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BCSC_ECOLI hmoment swissprot:BCSC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BCSC_ECOLI iep swissprot:BCSC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BCSC_ECOLI inforesidue swissprot:BCSC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BCSC_ECOLI octanol swissprot:BCSC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BCSC_ECOLI pepcoil swissprot:BCSC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BCSC_ECOLI pepdigest swissprot:BCSC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BCSC_ECOLI pepinfo swissprot:BCSC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BCSC_ECOLI pepnet swissprot:BCSC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BCSC_ECOLI pepstats swissprot:BCSC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BCSC_ECOLI pepwheel swissprot:BCSC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BCSC_ECOLI pepwindow swissprot:BCSC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BCSC_ECOLI sigcleave swissprot:BCSC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BCSC_ECOLI ## Database ID URL or Descriptions # BioGrid 4259245 156 # EcoGene EG13017 yqhG # InterPro IPR024289 DUF3828 # Organism YQHG_ECOLI Escherichia coli (strain K12) # PATRIC 32121442 VBIEscCol129921_3108 # PIR C65088 C65088 # Pfam PF12883 DUF3828; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQHG_ECOLI Uncharacterized protein YqhG # RefSeq WP_000691619 NZ_LN832404.1 # RefSeq YP_026195 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA69180.1; Type=Frameshift; Positions=98; Evidence={ECO:0000305}; Sequence=AAA69181.1; Type=Frameshift; Positions=98; Evidence={ECO 0000305}; # eggNOG ENOG4105ZKC Bacteria # eggNOG ENOG411283I LUCA BLAST swissprot:YQHG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQHG_ECOLI BioCyc ECOL316407:JW5500-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5500-MONOMER BioCyc EcoCyc:G7566-MONOMER http://biocyc.org/getid?id=EcoCyc:G7566-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2836 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2836 EcoGene EG13017 http://www.ecogene.org/geneInfo.php?eg_id=EG13017 EnsemblBacteria AAT48160 http://www.ensemblgenomes.org/id/AAT48160 EnsemblBacteria AAT48160 http://www.ensemblgenomes.org/id/AAT48160 EnsemblBacteria BAE77070 http://www.ensemblgenomes.org/id/BAE77070 EnsemblBacteria BAE77070 http://www.ensemblgenomes.org/id/BAE77070 EnsemblBacteria BAE77070 http://www.ensemblgenomes.org/id/BAE77070 EnsemblBacteria b3013 http://www.ensemblgenomes.org/id/b3013 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945919 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945919 HOGENOM HOG000125002 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125002&db=HOGENOM6 InterPro IPR024289 http://www.ebi.ac.uk/interpro/entry/IPR024289 KEGG_Gene ecj:JW5500 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5500 KEGG_Gene eco:b3013 http://www.genome.jp/dbget-bin/www_bget?eco:b3013 OMA WKIADFI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WKIADFI PSORT swissprot:YQHG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQHG_ECOLI PSORT-B swissprot:YQHG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQHG_ECOLI PSORT2 swissprot:YQHG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQHG_ECOLI Pfam PF12883 http://pfam.xfam.org/family/PF12883 Phobius swissprot:YQHG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQHG_ECOLI ProteinModelPortal Q46858 http://www.proteinmodelportal.org/query/uniprot/Q46858 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000691619 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000691619 RefSeq YP_026195 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026195 STRING 511145.b3013 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3013&targetmode=cogs UniProtKB YQHG_ECOLI http://www.uniprot.org/uniprot/YQHG_ECOLI UniProtKB-AC Q46858 http://www.uniprot.org/uniprot/Q46858 charge swissprot:YQHG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQHG_ECOLI eggNOG ENOG4105ZKC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ZKC eggNOG ENOG411283I http://eggnogapi.embl.de/nog_data/html/tree/ENOG411283I epestfind swissprot:YQHG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQHG_ECOLI garnier swissprot:YQHG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQHG_ECOLI helixturnhelix swissprot:YQHG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQHG_ECOLI hmoment swissprot:YQHG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQHG_ECOLI iep swissprot:YQHG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQHG_ECOLI inforesidue swissprot:YQHG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQHG_ECOLI octanol swissprot:YQHG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQHG_ECOLI pepcoil swissprot:YQHG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQHG_ECOLI pepdigest swissprot:YQHG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQHG_ECOLI pepinfo swissprot:YQHG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQHG_ECOLI pepnet swissprot:YQHG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQHG_ECOLI pepstats swissprot:YQHG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQHG_ECOLI pepwheel swissprot:YQHG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQHG_ECOLI pepwindow swissprot:YQHG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQHG_ECOLI sigcleave swissprot:YQHG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQHG_ECOLI ## Database ID URL or Descriptions # BioGrid 4263333 230 # EcoGene EG12288 yiaT # GO_component GO:0009279 cell outer membrane; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # InterPro IPR010583 MipA # Organism YIAT_ECOLI Escherichia coli (strain K12) # PATRIC 32122644 VBIEscCol129921_3699 # PIR S47805 S47805 # Pfam PF06629 MipA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIAT_ECOLI Putative outer membrane protein YiaT # RefSeq NP_418041 NC_000913.3 # RefSeq WP_000906819 NZ_LN832404.1 # SIMILARITY Belongs to the MipA/OmpV family. {ECO 0000305}. # SUBCELLULAR LOCATION YIAT_ECOLI Cell outer membrane {ECO 0000305}; Peripheral membrane protein {ECO 0000305}. # TCDB 9.B.99.1 the mipa-interacting protein (mipa) family # eggNOG COG3713 LUCA # eggNOG ENOG4105GNX Bacteria BLAST swissprot:YIAT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIAT_ECOLI BioCyc ECOL316407:JW3556-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3556-MONOMER BioCyc EcoCyc:EG12288-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12288-MONOMER COG COG3713 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3713 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2196 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2196 EcoGene EG12288 http://www.ecogene.org/geneInfo.php?eg_id=EG12288 EnsemblBacteria AAC76608 http://www.ensemblgenomes.org/id/AAC76608 EnsemblBacteria AAC76608 http://www.ensemblgenomes.org/id/AAC76608 EnsemblBacteria BAE77709 http://www.ensemblgenomes.org/id/BAE77709 EnsemblBacteria BAE77709 http://www.ensemblgenomes.org/id/BAE77709 EnsemblBacteria BAE77709 http://www.ensemblgenomes.org/id/BAE77709 EnsemblBacteria b3584 http://www.ensemblgenomes.org/id/b3584 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GeneID 948097 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948097 HOGENOM HOG000121141 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000121141&db=HOGENOM6 InParanoid P37681 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37681 InterPro IPR010583 http://www.ebi.ac.uk/interpro/entry/IPR010583 KEGG_Gene ecj:JW3556 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3556 KEGG_Gene eco:b3584 http://www.genome.jp/dbget-bin/www_bget?eco:b3584 KEGG_Orthology KO:K07274 http://www.genome.jp/dbget-bin/www_bget?KO:K07274 OMA HYHADAG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HYHADAG PSORT swissprot:YIAT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIAT_ECOLI PSORT-B swissprot:YIAT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIAT_ECOLI PSORT2 swissprot:YIAT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIAT_ECOLI Pfam PF06629 http://pfam.xfam.org/family/PF06629 Phobius swissprot:YIAT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIAT_ECOLI PhylomeDB P37681 http://phylomedb.org/?seqid=P37681 ProteinModelPortal P37681 http://www.proteinmodelportal.org/query/uniprot/P37681 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418041 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418041 RefSeq WP_000906819 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000906819 STRING 511145.b3584 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3584&targetmode=cogs STRING COG3713 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3713&targetmode=cogs TCDB 9.B.99.1 http://www.tcdb.org/search/result.php?tc=9.B.99.1 UniProtKB YIAT_ECOLI http://www.uniprot.org/uniprot/YIAT_ECOLI UniProtKB-AC P37681 http://www.uniprot.org/uniprot/P37681 charge swissprot:YIAT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIAT_ECOLI eggNOG COG3713 http://eggnogapi.embl.de/nog_data/html/tree/COG3713 eggNOG ENOG4105GNX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105GNX epestfind swissprot:YIAT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIAT_ECOLI garnier swissprot:YIAT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIAT_ECOLI helixturnhelix swissprot:YIAT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIAT_ECOLI hmoment swissprot:YIAT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIAT_ECOLI iep swissprot:YIAT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIAT_ECOLI inforesidue swissprot:YIAT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIAT_ECOLI octanol swissprot:YIAT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIAT_ECOLI pepcoil swissprot:YIAT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIAT_ECOLI pepdigest swissprot:YIAT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIAT_ECOLI pepinfo swissprot:YIAT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIAT_ECOLI pepnet swissprot:YIAT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIAT_ECOLI pepstats swissprot:YIAT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIAT_ECOLI pepwheel swissprot:YIAT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIAT_ECOLI pepwindow swissprot:YIAT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIAT_ECOLI sigcleave swissprot:YIAT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIAT_ECOLI ## Database ID URL or Descriptions # AltName HYI_ECOLI Glyoxylate-induced protein # BIOPHYSICOCHEMICAL PROPERTIES HYI_ECOLI Kinetic parameters KM=12.5 mM for hydroxypyruvate (at 37 degrees Celsius and pH 7.0) {ECO 0000269|PubMed 10561547}; Vmax=14.3 umol/min/mg enzyme (at 37 degrees Celsius and pH 7.0) {ECO 0000269|PubMed 10561547}; pH dependence Optimum pH is 6.8-7.2. {ECO 0000269|PubMed 10561547}; # BioGrid 4259863 8 # CATALYTIC ACTIVITY Hydroxypyruvate = 2-hydroxy-3-oxopropanoate. {ECO:0000269|PubMed 10561547}. # DISRUPTION PHENOTYPE Does not affect growth on glycolate or glyoxylate. {ECO:0000269|PubMed 8440684}. # ENZYME REGULATION Not stimulated by addition of pyridoxal 5'- phosphate (0.1 mM), FAD, NAD(+), NADP(+) or ATP (1 mM each). EDTA (10 mM) and metal ions (1 mM) such as Ca(2+), Co(2+), Mg(2+), Ni(2+), Zn(2+) do not affect the enzyme activity. {ECO:0000269|PubMed 10561547}. # EcoGene EG11584 hyi # FUNCTION HYI_ECOLI Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde). Does not catalyze the isomerization of D-fructose to D-glucose or that of D-xylulose to D-xylose. Also does not catalyze racemization of serine, alanine, glycerate or lactate. {ECO 0000269|PubMed 10561547}. # GO_function GO:0008903 hydroxypyruvate isomerase activity; IDA:FlyBase. # GO_function GO:0042803 protein homodimerization activity; IDA:FlyBase. # GO_process GO:0046487 glyoxylate metabolic process; IDA:FlyBase. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.150 -; 1. # INDUCTION HYI_ECOLI By glyoxylate. # IntAct P30147 12 # InterPro IPR013022 Xyl_isomerase-like_TIM-brl # InterPro IPR017643 Hydroxypyruvate_isomerase # InterPro IPR026040 HyI-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00630 Glyoxylate and dicarboxylate metabolism # Organism HYI_ECOLI Escherichia coli (strain K12) # PATRIC 32116175 VBIEscCol129921_0529 # PIR JT0746 JT0746 # PIRSF PIRSF006241 HyI # Pfam PF01261 AP_endonuc_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HYI_ECOLI Hydroxypyruvate isomerase # RefSeq NP_415041 NC_000913.3 # RefSeq WP_000943544 NZ_LN832404.1 # SIMILARITY Belongs to the hyi family. {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 10561547}. # SUPFAM SSF51658 SSF51658 # TIGRFAMs TIGR03234 OH-pyruv-isom # eggNOG COG3622 LUCA # eggNOG ENOG4105QG4 Bacteria BLAST swissprot:HYI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HYI_ECOLI BioCyc ECOL316407:JW0496-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0496-MONOMER BioCyc EcoCyc:G6277-MONOMER http://biocyc.org/getid?id=EcoCyc:G6277-MONOMER BioCyc MetaCyc:G6277-MONOMER http://biocyc.org/getid?id=MetaCyc:G6277-MONOMER COG COG3622 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3622 DIP DIP-9994N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9994N DOI 10.1016/S0167-4838(99)00216-2 http://dx.doi.org/10.1016/S0167-4838(99)00216-2 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.3.1.22 http://www.genome.jp/dbget-bin/www_bget?EC:5.3.1.22 EMBL AB028043 http://www.ebi.ac.uk/ena/data/view/AB028043 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L03845 http://www.ebi.ac.uk/ena/data/view/L03845 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 ENZYME 5.3.1.22 http://enzyme.expasy.org/EC/5.3.1.22 EchoBASE EB1543 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1543 EcoGene EG11584 http://www.ecogene.org/geneInfo.php?eg_id=EG11584 EnsemblBacteria AAC73610 http://www.ensemblgenomes.org/id/AAC73610 EnsemblBacteria AAC73610 http://www.ensemblgenomes.org/id/AAC73610 EnsemblBacteria BAE76286 http://www.ensemblgenomes.org/id/BAE76286 EnsemblBacteria BAE76286 http://www.ensemblgenomes.org/id/BAE76286 EnsemblBacteria BAE76286 http://www.ensemblgenomes.org/id/BAE76286 EnsemblBacteria b0508 http://www.ensemblgenomes.org/id/b0508 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008903 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008903 GO_function GO:0042803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803 GO_process GO:0046487 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046487 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.150 http://www.cathdb.info/version/latest/superfamily/3.20.20.150 GeneID 946186 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946186 HOGENOM HOG000218197 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218197&db=HOGENOM6 InParanoid P30147 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30147 IntAct P30147 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P30147* IntEnz 5.3.1.22 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.3.1.22 InterPro IPR013022 http://www.ebi.ac.uk/interpro/entry/IPR013022 InterPro IPR017643 http://www.ebi.ac.uk/interpro/entry/IPR017643 InterPro IPR026040 http://www.ebi.ac.uk/interpro/entry/IPR026040 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0496 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0496 KEGG_Gene eco:b0508 http://www.genome.jp/dbget-bin/www_bget?eco:b0508 KEGG_Orthology KO:K01816 http://www.genome.jp/dbget-bin/www_bget?KO:K01816 KEGG_Pathway ko00630 http://www.genome.jp/kegg-bin/show_pathway?ko00630 KEGG_Reaction rn:R01394 http://www.genome.jp/dbget-bin/www_bget?rn:R01394 OMA PDRVSEF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PDRVSEF PSORT swissprot:HYI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HYI_ECOLI PSORT-B swissprot:HYI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HYI_ECOLI PSORT2 swissprot:HYI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HYI_ECOLI Pfam PF01261 http://pfam.xfam.org/family/PF01261 Phobius swissprot:HYI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HYI_ECOLI PhylomeDB P30147 http://phylomedb.org/?seqid=P30147 ProteinModelPortal P30147 http://www.proteinmodelportal.org/query/uniprot/P30147 PubMed 10561547 http://www.ncbi.nlm.nih.gov/pubmed/10561547 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8440684 http://www.ncbi.nlm.nih.gov/pubmed/8440684 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415041 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415041 RefSeq WP_000943544 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000943544 SMR P30147 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P30147 STRING 511145.b0508 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0508&targetmode=cogs STRING COG3622 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3622&targetmode=cogs SUPFAM SSF51658 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51658 TIGRFAMs TIGR03234 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03234 UniProtKB HYI_ECOLI http://www.uniprot.org/uniprot/HYI_ECOLI UniProtKB-AC P30147 http://www.uniprot.org/uniprot/P30147 charge swissprot:HYI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HYI_ECOLI eggNOG COG3622 http://eggnogapi.embl.de/nog_data/html/tree/COG3622 eggNOG ENOG4105QG4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105QG4 epestfind swissprot:HYI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HYI_ECOLI garnier swissprot:HYI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HYI_ECOLI helixturnhelix swissprot:HYI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HYI_ECOLI hmoment swissprot:HYI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HYI_ECOLI iep swissprot:HYI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HYI_ECOLI inforesidue swissprot:HYI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HYI_ECOLI octanol swissprot:HYI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HYI_ECOLI pepcoil swissprot:HYI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HYI_ECOLI pepdigest swissprot:HYI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HYI_ECOLI pepinfo swissprot:HYI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HYI_ECOLI pepnet swissprot:HYI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HYI_ECOLI pepstats swissprot:HYI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HYI_ECOLI pepwheel swissprot:HYI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HYI_ECOLI pepwindow swissprot:HYI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HYI_ECOLI sigcleave swissprot:HYI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HYI_ECOLI ## Database ID URL or Descriptions # AltName 3-oxoacyl-[acyl-carrier-protein] synthase III {ECO:0000255|HAMAP-Rule MF_01815} # AltName Beta-ketoacyl-ACP synthase III {ECO:0000255|HAMAP-Rule MF_01815} # AltName FABH_ECOLI EcFabH # BRENDA 2.3.1.180 2026 # BioGrid 4261031 458 # CATALYTIC ACTIVITY Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO(2). {ECO:0000255|HAMAP-Rule MF_01815}. # DOMAIN FABH_ECOLI The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH. {ECO 0000255|HAMAP-Rule MF_01815, ECO 0000269|PubMed 11078736}. # DrugBank DB01034 Cerulenin # ENZYME REGULATION Negatively regulated by acyl-ACP, possibly by binding to either the free enzyme or the acyl-enzyme intermediate. {ECO:0000269|PubMed 8631920}. # EcoGene EG10277 fabH # FUNCTION FABH_ECOLI Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Has some substrate specificity for acetyl-CoA. Its substrate specificity determines the biosynthesis of straight-chain of fatty acids instead of branched-chain. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro. # GO_function GO:0033818 beta-ketoacyl-acyl-carrier-protein synthase III activity; IDA:EcoCyc. # GO_process GO:0006631 fatty acid metabolic process; IMP:CACAO. # GO_process GO:0006633 fatty acid biosynthetic process; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.47.10 -; 2. # HAMAP MF_01815 FabH # IntAct P0A6R0 5 # InterPro IPR004655 FabH_synth # InterPro IPR013747 ACP_syn_III_C # InterPro IPR013751 ACP_syn_III # InterPro IPR016039 Thiolase-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01004 Lipid biosynthesis proteins # KEGG_Pathway ko00061 Fatty acid biosynthesis # MISCELLANEOUS FABH_ECOLI Inhibited by the SB418011 antibiotic. Not inhibited by cerulenin and thiolactomycin. # Organism FABH_ECOLI Escherichia coli (strain K12) # PATHWAY Lipid metabolism; fatty acid biosynthesis. {ECO:0000255|HAMAP-Rule MF_01815}. # PATRIC 32117423 VBIEscCol129921_1134 # PDB 1EBL X-ray; 1.80 A; A/B=1-317 # PDB 1HN9 X-ray; 2.00 A; A/B=1-317 # PDB 1HND X-ray; 1.60 A; A=1-317 # PDB 1HNH X-ray; 1.90 A; A=1-317 # PDB 1HNJ X-ray; 1.46 A; A=1-317 # PDB 1HNK X-ray; 1.90 A; A=1-317 # PDB 1MZS X-ray; 2.10 A; A=1-317 # PDB 2EFT X-ray; 2.00 A; A/B=1-317 # PDB 2GYO X-ray; 2.00 A; A/B=1-317 # PDB 3IL9 X-ray; 1.85 A; A/B=1-317 # PDB 4Z8D X-ray; 2.00 A; A/B=1-317 # PDB 5BNM X-ray; 1.70 A; A/B=1-317 # PDB 5BNR X-ray; 1.89 A; A=1-317 # PDB 5BNS X-ray; 2.20 A; A/B=1-317 # PIR A42431 A42431 # Pfam PF08541 ACP_syn_III_C # Pfam PF08545 ACP_syn_III # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 3-oxoacyl-[acyl-carrier-protein] synthase 3 {ECO:0000255|HAMAP-Rule MF_01815} # RefSeq NP_415609 NC_000913.3 # RefSeq WP_000288132 NZ_LN832404.1 # SIMILARITY Belongs to the FabH family. {ECO:0000255|HAMAP- Rule MF_01815, ECO:0000305}. # SUBCELLULAR LOCATION FABH_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_01815}. # SUBUNIT Homodimer. {ECO:0000255|HAMAP-Rule MF_01815}. # SUPFAM SSF53901 SSF53901 # TIGRFAMs TIGR00747 fabH # eggNOG COG0332 LUCA # eggNOG ENOG4105CCZ Bacteria BLAST swissprot:FABH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FABH_ECOLI BioCyc ECOL316407:JW1077-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1077-MONOMER BioCyc EcoCyc:FABH-MONOMER http://biocyc.org/getid?id=EcoCyc:FABH-MONOMER BioCyc MetaCyc:FABH-MONOMER http://biocyc.org/getid?id=MetaCyc:FABH-MONOMER COG COG0332 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0332 DIP DIP-48255N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48255N DOI 10.1006/jmbi.2000.4457 http://dx.doi.org/10.1006/jmbi.2000.4457 DOI 10.1016/0014-5793(92)80128-4 http://dx.doi.org/10.1016/0014-5793(92)80128-4 DOI 10.1016/S0969-2126(00)00094-0 http://dx.doi.org/10.1016/S0969-2126(00)00094-0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.271.18.10996 http://dx.doi.org/10.1074/jbc.271.18.10996 DOI 10.1074/jbc.274.51.36465 http://dx.doi.org/10.1074/jbc.274.51.36465 DOI 10.1074/jbc.M008042200 http://dx.doi.org/10.1074/jbc.M008042200 DOI 10.1074/jbc.M101769200 http://dx.doi.org/10.1074/jbc.M101769200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB01034 http://www.drugbank.ca/drugs/DB01034 EC_number EC:2.3.1.180 {ECO:0000255|HAMAP-Rule:MF_01815} http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.180 {ECO:0000255|HAMAP-Rule:MF_01815} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M77744 http://www.ebi.ac.uk/ena/data/view/M77744 EMBL M87040 http://www.ebi.ac.uk/ena/data/view/M87040 EMBL M96793 http://www.ebi.ac.uk/ena/data/view/M96793 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL Z11565 http://www.ebi.ac.uk/ena/data/view/Z11565 ENZYME 2.3.1.180 {ECO:0000255|HAMAP-Rule:MF_01815} http://enzyme.expasy.org/EC/2.3.1.180 {ECO:0000255|HAMAP-Rule:MF_01815} EchoBASE EB0273 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0273 EcoGene EG10277 http://www.ecogene.org/geneInfo.php?eg_id=EG10277 EnsemblBacteria AAC74175 http://www.ensemblgenomes.org/id/AAC74175 EnsemblBacteria AAC74175 http://www.ensemblgenomes.org/id/AAC74175 EnsemblBacteria BAA35899 http://www.ensemblgenomes.org/id/BAA35899 EnsemblBacteria BAA35899 http://www.ensemblgenomes.org/id/BAA35899 EnsemblBacteria BAA35899 http://www.ensemblgenomes.org/id/BAA35899 EnsemblBacteria b1091 http://www.ensemblgenomes.org/id/b1091 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004315 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004315 GO_function GO:0033818 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033818 GO_process GO:0006631 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006631 GO_process GO:0006633 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006633 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.47.10 http://www.cathdb.info/version/latest/superfamily/3.40.47.10 GeneID 946003 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946003 HAMAP MF_01815 http://hamap.expasy.org/unirule/MF_01815 HOGENOM HOG000246674 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000246674&db=HOGENOM6 InParanoid P0A6R0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6R0 IntAct P0A6R0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6R0* IntEnz 2.3.1.180 {ECO:0000255|HAMAP-Rule:MF_01815} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.180 {ECO:0000255|HAMAP-Rule:MF_01815} InterPro IPR004655 http://www.ebi.ac.uk/interpro/entry/IPR004655 InterPro IPR013747 http://www.ebi.ac.uk/interpro/entry/IPR013747 InterPro IPR013751 http://www.ebi.ac.uk/interpro/entry/IPR013751 InterPro IPR016039 http://www.ebi.ac.uk/interpro/entry/IPR016039 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01004 http://www.genome.jp/dbget-bin/www_bget?ko01004 KEGG_Gene ecj:JW1077 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1077 KEGG_Gene eco:b1091 http://www.genome.jp/dbget-bin/www_bget?eco:b1091 KEGG_Orthology KO:K00648 http://www.genome.jp/dbget-bin/www_bget?KO:K00648 KEGG_Pathway ko00061 http://www.genome.jp/kegg-bin/show_pathway?ko00061 KEGG_Reaction rn:R01624 http://www.genome.jp/dbget-bin/www_bget?rn:R01624 KEGG_Reaction rn:R04355 http://www.genome.jp/dbget-bin/www_bget?rn:R04355 MINT MINT-1263292 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1263292 OMA ESGMYEN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ESGMYEN PDB 1EBL http://www.ebi.ac.uk/pdbe-srv/view/entry/1EBL PDB 1HN9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1HN9 PDB 1HND http://www.ebi.ac.uk/pdbe-srv/view/entry/1HND PDB 1HNH http://www.ebi.ac.uk/pdbe-srv/view/entry/1HNH PDB 1HNJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1HNJ PDB 1HNK http://www.ebi.ac.uk/pdbe-srv/view/entry/1HNK PDB 1MZS http://www.ebi.ac.uk/pdbe-srv/view/entry/1MZS PDB 2EFT http://www.ebi.ac.uk/pdbe-srv/view/entry/2EFT PDB 2GYO http://www.ebi.ac.uk/pdbe-srv/view/entry/2GYO PDB 3IL9 http://www.ebi.ac.uk/pdbe-srv/view/entry/3IL9 PDB 4Z8D http://www.ebi.ac.uk/pdbe-srv/view/entry/4Z8D PDB 5BNM http://www.ebi.ac.uk/pdbe-srv/view/entry/5BNM PDB 5BNR http://www.ebi.ac.uk/pdbe-srv/view/entry/5BNR PDB 5BNS http://www.ebi.ac.uk/pdbe-srv/view/entry/5BNS PDBsum 1EBL http://www.ebi.ac.uk/pdbsum/1EBL PDBsum 1HN9 http://www.ebi.ac.uk/pdbsum/1HN9 PDBsum 1HND http://www.ebi.ac.uk/pdbsum/1HND PDBsum 1HNH http://www.ebi.ac.uk/pdbsum/1HNH PDBsum 1HNJ http://www.ebi.ac.uk/pdbsum/1HNJ PDBsum 1HNK http://www.ebi.ac.uk/pdbsum/1HNK PDBsum 1MZS http://www.ebi.ac.uk/pdbsum/1MZS PDBsum 2EFT http://www.ebi.ac.uk/pdbsum/2EFT PDBsum 2GYO http://www.ebi.ac.uk/pdbsum/2GYO PDBsum 3IL9 http://www.ebi.ac.uk/pdbsum/3IL9 PDBsum 4Z8D http://www.ebi.ac.uk/pdbsum/4Z8D PDBsum 5BNM http://www.ebi.ac.uk/pdbsum/5BNM PDBsum 5BNR http://www.ebi.ac.uk/pdbsum/5BNR PDBsum 5BNS http://www.ebi.ac.uk/pdbsum/5BNS PSORT swissprot:FABH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FABH_ECOLI PSORT-B swissprot:FABH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FABH_ECOLI PSORT2 swissprot:FABH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FABH_ECOLI Pfam PF08541 http://pfam.xfam.org/family/PF08541 Pfam PF08545 http://pfam.xfam.org/family/PF08545 Phobius swissprot:FABH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FABH_ECOLI PhylomeDB P0A6R0 http://phylomedb.org/?seqid=P0A6R0 ProteinModelPortal P0A6R0 http://www.proteinmodelportal.org/query/uniprot/P0A6R0 PubMed 10593943 http://www.ncbi.nlm.nih.gov/pubmed/10593943 PubMed 10673437 http://www.ncbi.nlm.nih.gov/pubmed/10673437 PubMed 11078736 http://www.ncbi.nlm.nih.gov/pubmed/11078736 PubMed 11243824 http://www.ncbi.nlm.nih.gov/pubmed/11243824 PubMed 11375394 http://www.ncbi.nlm.nih.gov/pubmed/11375394 PubMed 1314802 http://www.ncbi.nlm.nih.gov/pubmed/1314802 PubMed 1339356 http://www.ncbi.nlm.nih.gov/pubmed/1339356 PubMed 1447160 http://www.ncbi.nlm.nih.gov/pubmed/1447160 PubMed 1551888 http://www.ncbi.nlm.nih.gov/pubmed/1551888 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8631920 http://www.ncbi.nlm.nih.gov/pubmed/8631920 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415609 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415609 RefSeq WP_000288132 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000288132 SMR P0A6R0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6R0 STRING 511145.b1091 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1091&targetmode=cogs STRING COG0332 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0332&targetmode=cogs SUPFAM SSF53901 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53901 TIGRFAMs TIGR00747 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00747 UniProtKB FABH_ECOLI http://www.uniprot.org/uniprot/FABH_ECOLI UniProtKB-AC P0A6R0 http://www.uniprot.org/uniprot/P0A6R0 charge swissprot:FABH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FABH_ECOLI eggNOG COG0332 http://eggnogapi.embl.de/nog_data/html/tree/COG0332 eggNOG ENOG4105CCZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CCZ epestfind swissprot:FABH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FABH_ECOLI garnier swissprot:FABH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FABH_ECOLI helixturnhelix swissprot:FABH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FABH_ECOLI hmoment swissprot:FABH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FABH_ECOLI iep swissprot:FABH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FABH_ECOLI inforesidue swissprot:FABH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FABH_ECOLI octanol swissprot:FABH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FABH_ECOLI pepcoil swissprot:FABH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FABH_ECOLI pepdigest swissprot:FABH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FABH_ECOLI pepinfo swissprot:FABH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FABH_ECOLI pepnet swissprot:FABH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FABH_ECOLI pepstats swissprot:FABH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FABH_ECOLI pepwheel swissprot:FABH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FABH_ECOLI pepwindow swissprot:FABH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FABH_ECOLI sigcleave swissprot:FABH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FABH_ECOLI ## Database ID URL or Descriptions # AltName RMLD_ECOLI dTDP-4-keto-L-rhamnose reductase # AltName RMLD_ECOLI dTDP-6-deoxy-L-lyxo-4-hexulose reductase # AltName RMLD_ECOLI dTDP-6-deoxy-L-mannose dehydrogenase # AltName RMLD_ECOLI dTDP-L-rhamnose synthase # BioGrid 4261549 162 # CATALYTIC ACTIVITY RMLD_ECOLI dTDP-beta-L-rhamnose + NADP(+) = dTDP-4- dehydro-beta-L-rhamnose + NADPH. # COFACTOR RMLD_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250}; Note=Binds 1 Mg(2+) ion per monomer. {ECO 0000250}; # EcoGene EG12411 rfbD # FUNCTION RMLD_ECOLI Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. RmlD uses NADH and NADPH nearly equally well (By similarity). {ECO 0000250}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008831 dTDP-4-dehydrorhamnose reductase activity; ISS:UniProtKB. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; ISS:UniProtKB. # GO_process GO:0009243 O antigen biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0019305 dTDP-rhamnose biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0045226 extracellular polysaccharide biosynthetic process; ISS:UniProtKB. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.50.720 -; 1. # IntAct P37760 5 # InterPro IPR005913 dTDP_dehydrorham_reduct # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR029903 RmlD-like-bd # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00521 Streptomycin biosynthesis # KEGG_Pathway ko00523 Polyketide sugar unit biosynthesis # Organism RMLD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10491 PTHR10491 # PATHWAY RMLD_ECOLI Bacterial outer membrane biogenesis; LPS O-antigen biosynthesis. # PATHWAY RMLD_ECOLI Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis. # PATRIC 32119413 VBIEscCol129921_2117 # PIR G64969 G64969 # Pfam PF04321 RmlD_sub_bind # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RMLD_ECOLI dTDP-4-dehydrorhamnose reductase # RefSeq NP_416544 NC_000913.3 # RefSeq WP_001023610 NZ_LN832404.1 # SIMILARITY Belongs to the dTDP-4-dehydrorhamnose reductase family. {ECO 0000305}. # SUBUNIT Homodimer. {ECO 0000250}. # SUPFAM SSF51735 SSF51735 # TIGRFAMs TIGR01214 rmlD # eggNOG COG1091 LUCA # eggNOG ENOG4105DBZ Bacteria BLAST swissprot:RMLD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RMLD_ECOLI BioCyc ECOL316407:JW2025-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2025-MONOMER BioCyc EcoCyc:DTDPDEHYRHAMREDUCT-MONOMER http://biocyc.org/getid?id=EcoCyc:DTDPDEHYRHAMREDUCT-MONOMER BioCyc MetaCyc:DTDPDEHYRHAMREDUCT-MONOMER http://biocyc.org/getid?id=MetaCyc:DTDPDEHYRHAMREDUCT-MONOMER COG COG1091 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1091 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.133 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.133 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U09876 http://www.ebi.ac.uk/ena/data/view/U09876 ENZYME 1.1.1.133 http://enzyme.expasy.org/EC/1.1.1.133 EchoBASE EB2310 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2310 EcoGene EG12411 http://www.ecogene.org/geneInfo.php?eg_id=EG12411 EnsemblBacteria AAC75101 http://www.ensemblgenomes.org/id/AAC75101 EnsemblBacteria AAC75101 http://www.ensemblgenomes.org/id/AAC75101 EnsemblBacteria BAA15882 http://www.ensemblgenomes.org/id/BAA15882 EnsemblBacteria BAA15882 http://www.ensemblgenomes.org/id/BAA15882 EnsemblBacteria BAA15882 http://www.ensemblgenomes.org/id/BAA15882 EnsemblBacteria b2040 http://www.ensemblgenomes.org/id/b2040 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008831 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008831 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GO_process GO:0009243 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009243 GO_process GO:0019305 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019305 GO_process GO:0045226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045226 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 947117 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947117 HOGENOM HOG000227712 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000227712&db=HOGENOM6 InParanoid P37760 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37760 IntAct P37760 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37760* IntEnz 1.1.1.133 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.133 InterPro IPR005913 http://www.ebi.ac.uk/interpro/entry/IPR005913 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR029903 http://www.ebi.ac.uk/interpro/entry/IPR029903 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2025 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2025 KEGG_Gene eco:b2040 http://www.genome.jp/dbget-bin/www_bget?eco:b2040 KEGG_Orthology KO:K00067 http://www.genome.jp/dbget-bin/www_bget?KO:K00067 KEGG_Pathway ko00521 http://www.genome.jp/kegg-bin/show_pathway?ko00521 KEGG_Pathway ko00523 http://www.genome.jp/kegg-bin/show_pathway?ko00523 KEGG_Reaction rn:R02777 http://www.genome.jp/dbget-bin/www_bget?rn:R02777 OMA GYASRYE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GYASRYE PANTHER PTHR10491 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10491 PSORT swissprot:RMLD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RMLD_ECOLI PSORT-B swissprot:RMLD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RMLD_ECOLI PSORT2 swissprot:RMLD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RMLD_ECOLI Pfam PF04321 http://pfam.xfam.org/family/PF04321 Phobius swissprot:RMLD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RMLD_ECOLI PhylomeDB P37760 http://phylomedb.org/?seqid=P37760 ProteinModelPortal P37760 http://www.proteinmodelportal.org/query/uniprot/P37760 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7517391 http://www.ncbi.nlm.nih.gov/pubmed/7517391 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416544 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416544 RefSeq WP_001023610 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001023610 SMR P37760 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37760 STRING 511145.b2040 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2040&targetmode=cogs STRING COG1091 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1091&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 TIGRFAMs TIGR01214 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01214 UniProtKB RMLD_ECOLI http://www.uniprot.org/uniprot/RMLD_ECOLI UniProtKB-AC P37760 http://www.uniprot.org/uniprot/P37760 charge swissprot:RMLD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RMLD_ECOLI eggNOG COG1091 http://eggnogapi.embl.de/nog_data/html/tree/COG1091 eggNOG ENOG4105DBZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DBZ epestfind swissprot:RMLD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RMLD_ECOLI garnier swissprot:RMLD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RMLD_ECOLI helixturnhelix swissprot:RMLD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RMLD_ECOLI hmoment swissprot:RMLD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RMLD_ECOLI iep swissprot:RMLD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RMLD_ECOLI inforesidue swissprot:RMLD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RMLD_ECOLI octanol swissprot:RMLD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RMLD_ECOLI pepcoil swissprot:RMLD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RMLD_ECOLI pepdigest swissprot:RMLD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RMLD_ECOLI pepinfo swissprot:RMLD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RMLD_ECOLI pepnet swissprot:RMLD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RMLD_ECOLI pepstats swissprot:RMLD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RMLD_ECOLI pepwheel swissprot:RMLD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RMLD_ECOLI pepwindow swissprot:RMLD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RMLD_ECOLI sigcleave swissprot:RMLD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RMLD_ECOLI ## Database ID URL or Descriptions # AltName 3MG2_ECOLI 3-methyladenine-DNA glycosylase II, inducible # AltName 3MG2_ECOLI DNA-3-methyladenine glycosidase II # AltName 3MG2_ECOLI DNA-3-methyladenine glycosylase II # BRENDA 3.2.2.21 2026 # BioGrid 4259681 55 # CATALYTIC ACTIVITY 3MG2_ECOLI Hydrolysis of alkylated DNA, releasing 3- methyladenine, 3-methylguanine, 7-methylguanine and 7- methyladenine. # CDD cd00056 ENDO3c # EcoGene EG11222 alkA # FUNCTION 3MG2_ECOLI Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, 3-methylguanine, 7-methylguanine, O2- methylthymine, and O2-methylcytosine from the damaged DNA polymer formed by alkylation lesions. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0032993 protein-DNA complex; IBA:GO_Central. # GO_function GO:0003905 alkylbase DNA N-glycosylase activity; IDA:EcoliWiki. # GO_function GO:0008725 DNA-3-methyladenine glycosylase activity; IBA:GO_Central. # GO_function GO:0032131 alkylated DNA binding; IBA:GO_Central. # GO_function GO:0043916 DNA-7-methylguanine glycosylase activity; IBA:GO_Central. # GO_function GO:0052821 DNA-7-methyladenine glycosylase activity; IEA:UniProtKB-EC. # GO_function GO:0052822 DNA-3-methylguanine glycosylase activity; IEA:UniProtKB-EC. # GO_process GO:0006281 DNA repair; IDA:EcoliWiki. # GO_process GO:0006284 base-excision repair; IDA:EcoliWiki. # GO_process GO:0006285 base-excision repair, AP site formation; IBA:GO_Central. # GO_process GO:0006307 DNA dealkylation involved in DNA repair; IMP:EcoliWiki. # GO_process GO:0006974 cellular response to DNA damage stimulus; IMP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # Gene3D 1.10.1670.10 -; 1. # Gene3D 1.10.340.30 -; 1. # Gene3D 3.30.310.20 -; 1. # INDUCTION 3MG2_ECOLI Up-regulated by methylated Ada in response to the exposure to alkylating agents. # IntAct P04395 19 # InterPro IPR000035 Alkylbase_DNA_glycsylse_CS # InterPro IPR003265 HhH-GPD_domain # InterPro IPR010316 AlkA_N # InterPro IPR011257 DNA_glycosylase # InterPro IPR023170 HTH_base_excis_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko03410 Base excision repair # Organism 3MG2_ECOLI Escherichia coli (strain K12) # PATRIC 32119469 VBIEscCol129921_2145 # PDB 1DIZ X-ray; 2.50 A; A/B=1-282 # PDB 1MPG X-ray; 1.80 A; A/B=1-282 # PDB 1PVS X-ray; 2.40 A; A/B=1-282 # PDB 3CVS X-ray; 2.40 A; A/B/C/D=1-282 # PDB 3CVT X-ray; 2.50 A; A/B/C/D=1-282 # PDB 3CW7 X-ray; 2.30 A; A/B/C/D=1-282 # PDB 3CWA X-ray; 2.40 A; A/B/C/D=1-282 # PDB 3CWS X-ray; 2.30 A; A/B/C/D=1-282 # PDB 3CWT X-ray; 2.30 A; A/B/C/D=1-282 # PDB 3CWU X-ray; 2.80 A; A/B/C/D=1-282 # PDB 3D4V X-ray; 2.90 A; A/B/C/D=1-282 # PDB 3OGD X-ray; 2.80 A; A=2-282 # PDB 3OH6 X-ray; 2.89 A; A=2-282 # PDB 3OH9 X-ray; 2.80 A; A=2-282 # PIR A00904 DGECMA # PROSITE PS00516 ALKYLBASE_DNA_GLYCOS # Pfam PF00730 HhH-GPD # Pfam PF06029 AlkA_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 3MG2_ECOLI DNA-3-methyladenine glycosylase 2 # RefSeq NP_416572 NC_000913.3 # RefSeq WP_000288420 NZ_LN832404.1 # SIMILARITY Belongs to the alkylbase DNA glycosidase AlkA family. {ECO 0000305}. # SMART SM00478 ENDO3c # SMART SM01009 AlkA_N # SUBUNIT 3MG2_ECOLI Monomer. # SUPFAM SSF48150 SSF48150 # eggNOG COG0122 LUCA # eggNOG ENOG4105D03 Bacteria BLAST swissprot:3MG2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:3MG2_ECOLI BioCyc ECOL316407:JW2053-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2053-MONOMER BioCyc EcoCyc:EG11222-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11222-MONOMER BioCyc MetaCyc:EG11222-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11222-MONOMER COG COG0122 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0122 DIP DIP-9084N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9084N DOI 10.1016/S0092-8674(00)80102-6 http://dx.doi.org/10.1016/S0092-8674(00)80102-6 DOI 10.1016/S0092-8674(00)80103-8 http://dx.doi.org/10.1016/S0092-8674(00)80103-8 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.83.17.6297 http://dx.doi.org/10.1073/pnas.83.17.6297 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.2.2.21 http://www.genome.jp/dbget-bin/www_bget?EC:3.2.2.21 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K02498 http://www.ebi.ac.uk/ena/data/view/K02498 EMBL M13827 http://www.ebi.ac.uk/ena/data/view/M13827 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.2.2.21 http://enzyme.expasy.org/EC/3.2.2.21 EchoBASE EB1204 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1204 EcoGene EG11222 http://www.ecogene.org/geneInfo.php?eg_id=EG11222 EnsemblBacteria AAC75129 http://www.ensemblgenomes.org/id/AAC75129 EnsemblBacteria AAC75129 http://www.ensemblgenomes.org/id/AAC75129 EnsemblBacteria BAA15926 http://www.ensemblgenomes.org/id/BAA15926 EnsemblBacteria BAA15926 http://www.ensemblgenomes.org/id/BAA15926 EnsemblBacteria BAA15926 http://www.ensemblgenomes.org/id/BAA15926 EnsemblBacteria b2068 http://www.ensemblgenomes.org/id/b2068 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0032993 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032993 GO_function GO:0003905 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003905 GO_function GO:0008725 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008725 GO_function GO:0032131 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032131 GO_function GO:0043916 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043916 GO_function GO:0052821 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052821 GO_function GO:0052822 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052822 GO_process GO:0006281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006281 GO_process GO:0006284 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006284 GO_process GO:0006285 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006285 GO_process GO:0006307 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006307 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 1.10.1670.10 http://www.cathdb.info/version/latest/superfamily/1.10.1670.10 Gene3D 1.10.340.30 http://www.cathdb.info/version/latest/superfamily/1.10.340.30 Gene3D 3.30.310.20 http://www.cathdb.info/version/latest/superfamily/3.30.310.20 GeneID 947371 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947371 HOGENOM HOG000221908 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000221908&db=HOGENOM6 InParanoid P04395 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P04395 IntAct P04395 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P04395* IntEnz 3.2.2.21 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.2.2.21 InterPro IPR000035 http://www.ebi.ac.uk/interpro/entry/IPR000035 InterPro IPR003265 http://www.ebi.ac.uk/interpro/entry/IPR003265 InterPro IPR010316 http://www.ebi.ac.uk/interpro/entry/IPR010316 InterPro IPR011257 http://www.ebi.ac.uk/interpro/entry/IPR011257 InterPro IPR023170 http://www.ebi.ac.uk/interpro/entry/IPR023170 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW2053 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2053 KEGG_Gene eco:b2068 http://www.genome.jp/dbget-bin/www_bget?eco:b2068 KEGG_Orthology KO:K01247 http://www.genome.jp/dbget-bin/www_bget?KO:K01247 KEGG_Pathway ko03410 http://www.genome.jp/kegg-bin/show_pathway?ko03410 MINT MINT-1227621 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1227621 OMA LHIWYTD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LHIWYTD PDB 1DIZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1DIZ PDB 1MPG http://www.ebi.ac.uk/pdbe-srv/view/entry/1MPG PDB 1PVS http://www.ebi.ac.uk/pdbe-srv/view/entry/1PVS PDB 3CVS http://www.ebi.ac.uk/pdbe-srv/view/entry/3CVS PDB 3CVT http://www.ebi.ac.uk/pdbe-srv/view/entry/3CVT PDB 3CW7 http://www.ebi.ac.uk/pdbe-srv/view/entry/3CW7 PDB 3CWA http://www.ebi.ac.uk/pdbe-srv/view/entry/3CWA PDB 3CWS http://www.ebi.ac.uk/pdbe-srv/view/entry/3CWS PDB 3CWT http://www.ebi.ac.uk/pdbe-srv/view/entry/3CWT PDB 3CWU http://www.ebi.ac.uk/pdbe-srv/view/entry/3CWU PDB 3D4V http://www.ebi.ac.uk/pdbe-srv/view/entry/3D4V PDB 3OGD http://www.ebi.ac.uk/pdbe-srv/view/entry/3OGD PDB 3OH6 http://www.ebi.ac.uk/pdbe-srv/view/entry/3OH6 PDB 3OH9 http://www.ebi.ac.uk/pdbe-srv/view/entry/3OH9 PDBsum 1DIZ http://www.ebi.ac.uk/pdbsum/1DIZ PDBsum 1MPG http://www.ebi.ac.uk/pdbsum/1MPG PDBsum 1PVS http://www.ebi.ac.uk/pdbsum/1PVS PDBsum 3CVS http://www.ebi.ac.uk/pdbsum/3CVS PDBsum 3CVT http://www.ebi.ac.uk/pdbsum/3CVT PDBsum 3CW7 http://www.ebi.ac.uk/pdbsum/3CW7 PDBsum 3CWA http://www.ebi.ac.uk/pdbsum/3CWA PDBsum 3CWS http://www.ebi.ac.uk/pdbsum/3CWS PDBsum 3CWT http://www.ebi.ac.uk/pdbsum/3CWT PDBsum 3CWU http://www.ebi.ac.uk/pdbsum/3CWU PDBsum 3D4V http://www.ebi.ac.uk/pdbsum/3D4V PDBsum 3OGD http://www.ebi.ac.uk/pdbsum/3OGD PDBsum 3OH6 http://www.ebi.ac.uk/pdbsum/3OH6 PDBsum 3OH9 http://www.ebi.ac.uk/pdbsum/3OH9 PROSITE PS00516 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00516 PSORT swissprot:3MG2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:3MG2_ECOLI PSORT-B swissprot:3MG2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:3MG2_ECOLI PSORT2 swissprot:3MG2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:3MG2_ECOLI Pfam PF00730 http://pfam.xfam.org/family/PF00730 Pfam PF06029 http://pfam.xfam.org/family/PF06029 Phobius swissprot:3MG2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:3MG2_ECOLI PhylomeDB P04395 http://phylomedb.org/?seqid=P04395 ProteinModelPortal P04395 http://www.proteinmodelportal.org/query/uniprot/P04395 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3529081 http://www.ncbi.nlm.nih.gov/pubmed/3529081 PubMed 6094528 http://www.ncbi.nlm.nih.gov/pubmed/6094528 PubMed 6389535 http://www.ncbi.nlm.nih.gov/pubmed/6389535 PubMed 8706135 http://www.ncbi.nlm.nih.gov/pubmed/8706135 PubMed 8706136 http://www.ncbi.nlm.nih.gov/pubmed/8706136 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416572 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416572 RefSeq WP_000288420 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000288420 SMART SM00478 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00478 SMART SM01009 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01009 SMR P04395 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P04395 STRING 511145.b2068 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2068&targetmode=cogs STRING COG0122 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0122&targetmode=cogs SUPFAM SSF48150 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48150 UniProtKB 3MG2_ECOLI http://www.uniprot.org/uniprot/3MG2_ECOLI UniProtKB-AC P04395 http://www.uniprot.org/uniprot/P04395 charge swissprot:3MG2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:3MG2_ECOLI eggNOG COG0122 http://eggnogapi.embl.de/nog_data/html/tree/COG0122 eggNOG ENOG4105D03 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D03 epestfind swissprot:3MG2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:3MG2_ECOLI garnier swissprot:3MG2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:3MG2_ECOLI helixturnhelix swissprot:3MG2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:3MG2_ECOLI hmoment swissprot:3MG2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:3MG2_ECOLI iep swissprot:3MG2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:3MG2_ECOLI inforesidue swissprot:3MG2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:3MG2_ECOLI octanol swissprot:3MG2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:3MG2_ECOLI pepcoil swissprot:3MG2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:3MG2_ECOLI pepdigest swissprot:3MG2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:3MG2_ECOLI pepinfo swissprot:3MG2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:3MG2_ECOLI pepnet swissprot:3MG2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:3MG2_ECOLI pepstats swissprot:3MG2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:3MG2_ECOLI pepwheel swissprot:3MG2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:3MG2_ECOLI pepwindow swissprot:3MG2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:3MG2_ECOLI sigcleave swissprot:3MG2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:3MG2_ECOLI ## Database ID URL or Descriptions # BRENDA 6.3.4.21 2026 # BioGrid 4261881 11 # CATALYTIC ACTIVITY PNCB_ECOLI Nicotinate + 5-phospho-alpha-D-ribose 1- diphosphate + ATP + H(2)O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate. {ECO 0000255|HAMAP-Rule MF_00570, ECO 0000269|PubMed 2211655}. # EcoGene EG10742 pncB # FUNCTION PNCB_ECOLI Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP. {ECO 0000255|HAMAP-Rule MF_00570, ECO 0000269|PubMed 2211655}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity; IEA:InterPro. # GO_function GO:0004516 nicotinate phosphoribosyltransferase activity; IDA:EcoCyc. # GO_function GO:0016879 ligase activity, forming carbon-nitrogen bonds; IDA:UniProtKB. # GO_process GO:0009408 response to heat; IMP:EcoCyc. # GO_process GO:0009435 NAD biosynthetic process; IDA:UniProtKB. # GO_process GO:0019357 nicotinate nucleotide biosynthetic process; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_function GO:0016874 ligase activity # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # HAMAP MF_00570 NAPRTase # IntAct P18133 19 # InterPro IPR002638 Quinolinate_PRibosylTrfase_C # InterPro IPR006406 Nic_PRibTrfase # InterPro IPR007229 Nic_PRibTrfase-Fam # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00760 Nicotinate and nicotinamide metabolism # Organism PNCB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11098 PTHR11098 # PATHWAY Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D- ribonucleotide from nicotinate: step 1/1. {ECO 0000255|HAMAP- Rule:MF_00570}. # PATRIC 32117079 VBIEscCol129921_0964 # PIR JQ0756 JQ0756 # PIRSF PIRSF000484 NAPRT # Pfam PF04095 NAPRTase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Nicotinate phosphoribosyltransferase {ECO:0000255|HAMAP-Rule MF_00570} # RefSeq NP_415451 NC_000913.3 # RefSeq WP_001307697 NZ_LN832404.1 # SIMILARITY Belongs to the NAPRTase family. {ECO:0000255|HAMAP- Rule MF_00570}. # SUPFAM SSF51690 SSF51690 # TIGRFAMs TIGR01514 NAPRTase # UniPathway UPA00253 UER00457 # eggNOG COG1488 LUCA # eggNOG ENOG4107RH7 Bacteria BLAST swissprot:PNCB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PNCB_ECOLI BioCyc ECOL316407:JW0914-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0914-MONOMER BioCyc EcoCyc:NICOTINATEPRIBOSYLTRANS-MONOMER http://biocyc.org/getid?id=EcoCyc:NICOTINATEPRIBOSYLTRANS-MONOMER BioCyc MetaCyc:NICOTINATEPRIBOSYLTRANS-MONOMER http://biocyc.org/getid?id=MetaCyc:NICOTINATEPRIBOSYLTRANS-MONOMER COG COG1488 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1488 DIP DIP-10521N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10521N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.3.4.21 {ECO:0000255|HAMAP-Rule:MF_00570} http://www.genome.jp/dbget-bin/www_bget?EC:6.3.4.21 {ECO:0000255|HAMAP-Rule:MF_00570} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J05568 http://www.ebi.ac.uk/ena/data/view/J05568 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 6.3.4.21 {ECO:0000255|HAMAP-Rule:MF_00570} http://enzyme.expasy.org/EC/6.3.4.21 {ECO:0000255|HAMAP-Rule:MF_00570} EchoBASE EB0735 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0735 EcoGene EG10742 http://www.ecogene.org/geneInfo.php?eg_id=EG10742 EnsemblBacteria AAC74017 http://www.ensemblgenomes.org/id/AAC74017 EnsemblBacteria AAC74017 http://www.ensemblgenomes.org/id/AAC74017 EnsemblBacteria BAA35683 http://www.ensemblgenomes.org/id/BAA35683 EnsemblBacteria BAA35683 http://www.ensemblgenomes.org/id/BAA35683 EnsemblBacteria BAA35683 http://www.ensemblgenomes.org/id/BAA35683 EnsemblBacteria b0931 http://www.ensemblgenomes.org/id/b0931 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004514 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004514 GO_function GO:0004516 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004516 GO_function GO:0016879 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016879 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GO_process GO:0009435 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009435 GO_process GO:0019357 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019357 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GeneID 946648 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946648 HAMAP MF_00570 http://hamap.expasy.org/unirule/MF_00570 HOGENOM HOG000284928 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000284928&db=HOGENOM6 InParanoid P18133 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P18133 IntAct P18133 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P18133* IntEnz 6.3.4.21 {ECO:0000255|HAMAP-Rule:MF_00570} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.4.21 {ECO:0000255|HAMAP-Rule:MF_00570} InterPro IPR002638 http://www.ebi.ac.uk/interpro/entry/IPR002638 InterPro IPR006406 http://www.ebi.ac.uk/interpro/entry/IPR006406 InterPro IPR007229 http://www.ebi.ac.uk/interpro/entry/IPR007229 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0914 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0914 KEGG_Gene eco:b0931 http://www.genome.jp/dbget-bin/www_bget?eco:b0931 KEGG_Orthology KO:K00763 http://www.genome.jp/dbget-bin/www_bget?KO:K00763 KEGG_Pathway ko00760 http://www.genome.jp/kegg-bin/show_pathway?ko00760 KEGG_Reaction rn:R01724 http://www.genome.jp/dbget-bin/www_bget?rn:R01724 MINT MINT-1246310 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1246310 OMA KLTMQCA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KLTMQCA PANTHER PTHR11098 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11098 PSORT swissprot:PNCB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PNCB_ECOLI PSORT-B swissprot:PNCB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PNCB_ECOLI PSORT2 swissprot:PNCB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PNCB_ECOLI Pfam PF04095 http://pfam.xfam.org/family/PF04095 Phobius swissprot:PNCB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PNCB_ECOLI PhylomeDB P18133 http://phylomedb.org/?seqid=P18133 ProteinModelPortal P18133 http://www.proteinmodelportal.org/query/uniprot/P18133 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2211655 http://www.ncbi.nlm.nih.gov/pubmed/2211655 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415451 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415451 RefSeq WP_001307697 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001307697 SMR P18133 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P18133 STRING 511145.b0931 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0931&targetmode=cogs STRING COG1488 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1488&targetmode=cogs SUPFAM SSF51690 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51690 TIGRFAMs TIGR01514 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01514 UniProtKB PNCB_ECOLI http://www.uniprot.org/uniprot/PNCB_ECOLI UniProtKB-AC P18133 http://www.uniprot.org/uniprot/P18133 charge swissprot:PNCB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PNCB_ECOLI eggNOG COG1488 http://eggnogapi.embl.de/nog_data/html/tree/COG1488 eggNOG ENOG4107RH7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107RH7 epestfind swissprot:PNCB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PNCB_ECOLI garnier swissprot:PNCB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PNCB_ECOLI helixturnhelix swissprot:PNCB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PNCB_ECOLI hmoment swissprot:PNCB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PNCB_ECOLI iep swissprot:PNCB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PNCB_ECOLI inforesidue swissprot:PNCB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PNCB_ECOLI octanol swissprot:PNCB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PNCB_ECOLI pepcoil swissprot:PNCB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PNCB_ECOLI pepdigest swissprot:PNCB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PNCB_ECOLI pepinfo swissprot:PNCB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PNCB_ECOLI pepnet swissprot:PNCB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PNCB_ECOLI pepstats swissprot:PNCB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PNCB_ECOLI pepwheel swissprot:PNCB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PNCB_ECOLI pepwindow swissprot:PNCB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PNCB_ECOLI sigcleave swissprot:PNCB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PNCB_ECOLI ## Database ID URL or Descriptions # AltName NARK_ECOLI Nitrite extrusion protein 1 # AltName NARK_ECOLI Nitrite facilitator 1 # BioGrid 4261633 13 # EcoGene EG10642 narK # FUNCTION NARK_ECOLI Catalyzes nitrate uptake, nitrite uptake and nitrite export across the cytoplasmic membrane. Functions as a nitrate/nitrite exchanger, and protons are probably not co- transported with the substrate. {ECO 0000269|PubMed 11967075, ECO 0000269|PubMed 15667293, ECO 0000269|PubMed 16804183, ECO 0000269|PubMed 23665960, ECO 0000269|PubMed 2668029}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_function GO:0005452 inorganic anion exchanger activity; IDA:EcoCyc. # GO_function GO:0015112 nitrate transmembrane transporter activity; IEA:InterPro. # GO_function GO:0015113 nitrite transmembrane transporter activity; IEA:InterPro. # GO_process GO:0042128 nitrate assimilation; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0071941 nitrogen cycle metabolic process # INDUCTION NARK_ECOLI Highly expressed during anaerobic growth in the presence of nitrate. {ECO 0000269|PubMed 16804183, ECO 0000269|PubMed 2668029}. # InterPro IPR004737 NO3_transporter # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # KEGG_Brite ko02000 Transporters # Organism NARK_ECOLI Escherichia coli (strain K12) # PATRIC 32117706 VBIEscCol129921_1275 # PDB 4JR9 X-ray; 2.60 A; A=1-463 # PDB 4JRE X-ray; 2.80 A; A/D=1-463 # PDB 4U4T X-ray; 2.40 A; A=1-463 # PDB 4U4V X-ray; 2.35 A; A=1-463 # PDB 4U4W X-ray; 2.40 A; A/B=1-463 # PIR S05239 GRECNK # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NARK_ECOLI Nitrate/nitrite transporter NarK # RefSeq NP_415741 NC_000913.3 # RefSeq WP_000019827 NZ_LN832404.1 # SIMILARITY Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family. {ECO 0000305}. # SUBCELLULAR LOCATION NARK_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.8 the major facilitator superfamily (mfs) # TIGRFAMs TIGR00886 2A0108 # eggNOG COG2223 LUCA # eggNOG ENOG4105DQQ Bacteria BLAST swissprot:NARK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NARK_ECOLI BioCyc ECOL316407:JW1214-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1214-MONOMER BioCyc EcoCyc:NARK-MONOMER http://biocyc.org/getid?id=EcoCyc:NARK-MONOMER BioCyc MetaCyc:NARK-MONOMER http://biocyc.org/getid?id=MetaCyc:NARK-MONOMER COG COG2223 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2223 DOI 10.1016/0014-5793(89)80906-8 http://dx.doi.org/10.1016/0014-5793(89)80906-8 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature12139 http://dx.doi.org/10.1038/nature12139 DOI 10.1042/BJ20080746 http://dx.doi.org/10.1042/BJ20080746 DOI 10.1042/BST0330159 http://dx.doi.org/10.1042/BST0330159 DOI 10.1046/j.1365-2958.2002.02858.x http://dx.doi.org/10.1046/j.1365-2958.2002.02858.x DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/17.8.2947 http://dx.doi.org/10.1093/nar/17.8.2947 DOI 10.1099/mic.0.28688-0 http://dx.doi.org/10.1099/mic.0.28688-0 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X13360 http://www.ebi.ac.uk/ena/data/view/X13360 EMBL X15996 http://www.ebi.ac.uk/ena/data/view/X15996 EMBL X69189 http://www.ebi.ac.uk/ena/data/view/X69189 EchoBASE EB0636 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0636 EcoGene EG10642 http://www.ecogene.org/geneInfo.php?eg_id=EG10642 EnsemblBacteria AAC74307 http://www.ensemblgenomes.org/id/AAC74307 EnsemblBacteria AAC74307 http://www.ensemblgenomes.org/id/AAC74307 EnsemblBacteria BAA36091 http://www.ensemblgenomes.org/id/BAA36091 EnsemblBacteria BAA36091 http://www.ensemblgenomes.org/id/BAA36091 EnsemblBacteria BAA36091 http://www.ensemblgenomes.org/id/BAA36091 EnsemblBacteria b1223 http://www.ensemblgenomes.org/id/b1223 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0005452 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005452 GO_function GO:0015112 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015112 GO_function GO:0015113 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015113 GO_process GO:0042128 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042128 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0071941 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071941 GeneID 945783 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945783 HOGENOM HOG000241722 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000241722&db=HOGENOM6 InParanoid P10903 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P10903 InterPro IPR004737 http://www.ebi.ac.uk/interpro/entry/IPR004737 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1214 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1214 KEGG_Gene eco:b1223 http://www.genome.jp/dbget-bin/www_bget?eco:b1223 KEGG_Orthology KO:K02575 http://www.genome.jp/dbget-bin/www_bget?KO:K02575 OMA FAFFGPF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FAFFGPF PDB 4JR9 http://www.ebi.ac.uk/pdbe-srv/view/entry/4JR9 PDB 4JRE http://www.ebi.ac.uk/pdbe-srv/view/entry/4JRE PDB 4U4T http://www.ebi.ac.uk/pdbe-srv/view/entry/4U4T PDB 4U4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U4V PDB 4U4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4U4W PDBsum 4JR9 http://www.ebi.ac.uk/pdbsum/4JR9 PDBsum 4JRE http://www.ebi.ac.uk/pdbsum/4JRE PDBsum 4U4T http://www.ebi.ac.uk/pdbsum/4U4T PDBsum 4U4V http://www.ebi.ac.uk/pdbsum/4U4V PDBsum 4U4W http://www.ebi.ac.uk/pdbsum/4U4W PSORT swissprot:NARK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NARK_ECOLI PSORT-B swissprot:NARK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NARK_ECOLI PSORT2 swissprot:NARK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NARK_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:NARK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NARK_ECOLI PhylomeDB P10903 http://phylomedb.org/?seqid=P10903 ProteinModelPortal P10903 http://www.proteinmodelportal.org/query/uniprot/P10903 PubMed 11967075 http://www.ncbi.nlm.nih.gov/pubmed/11967075 PubMed 15667293 http://www.ncbi.nlm.nih.gov/pubmed/15667293 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16804183 http://www.ncbi.nlm.nih.gov/pubmed/16804183 PubMed 18691156 http://www.ncbi.nlm.nih.gov/pubmed/18691156 PubMed 23665960 http://www.ncbi.nlm.nih.gov/pubmed/23665960 PubMed 2657652 http://www.ncbi.nlm.nih.gov/pubmed/2657652 PubMed 2668029 http://www.ncbi.nlm.nih.gov/pubmed/2668029 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415741 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415741 RefSeq WP_000019827 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000019827 SMR P10903 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P10903 STRING 511145.b1223 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1223&targetmode=cogs STRING COG2223 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2223&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.8 http://www.tcdb.org/search/result.php?tc=2.A.1.8 TIGRFAMs TIGR00886 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00886 UniProtKB NARK_ECOLI http://www.uniprot.org/uniprot/NARK_ECOLI UniProtKB-AC P10903 http://www.uniprot.org/uniprot/P10903 charge swissprot:NARK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NARK_ECOLI eggNOG COG2223 http://eggnogapi.embl.de/nog_data/html/tree/COG2223 eggNOG ENOG4105DQQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DQQ epestfind swissprot:NARK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NARK_ECOLI garnier swissprot:NARK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NARK_ECOLI helixturnhelix swissprot:NARK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NARK_ECOLI hmoment swissprot:NARK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NARK_ECOLI iep swissprot:NARK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NARK_ECOLI inforesidue swissprot:NARK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NARK_ECOLI octanol swissprot:NARK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NARK_ECOLI pepcoil swissprot:NARK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NARK_ECOLI pepdigest swissprot:NARK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NARK_ECOLI pepinfo swissprot:NARK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NARK_ECOLI pepnet swissprot:NARK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NARK_ECOLI pepstats swissprot:NARK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NARK_ECOLI pepwheel swissprot:NARK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NARK_ECOLI pepwindow swissprot:NARK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NARK_ECOLI sigcleave swissprot:NARK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NARK_ECOLI ## Database ID URL or Descriptions # BioGrid 4260693 11 # EcoGene EG13286 nrdH # FUNCTION NRDH_ECOLI Electron transport system for the ribonucleotide reductase system NrdEF. # GO_component GO:0005623 cell; IEA:GOC. # GO_function GO:0009055 electron carrier activity; IDA:EcoCyc. # GO_function GO:0015035 protein disulfide oxidoreductase activity; IEA:InterPro. # GO_process GO:0045454 cell redox homeostasis; IDA:EcoCyc. # GO_process GO:0051353 positive regulation of oxidoreductase activity; IMP:EcoCyc. # GOslim_component GO:0005623 cell # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0042592 homeostatic process # Gene3D 3.40.30.10 -; 1. # INDUCTION Induced 2-fold by hydroxyurea. {ECO:0000269|PubMed 20005847}. # IntAct P0AC65 7 # InterPro IPR002109 Glutaredoxin # InterPro IPR011909 GlrX_NrdH # InterPro IPR012336 Thioredoxin-like_fold # Organism NRDH_ECOLI Escherichia coli (strain K12) # PATRIC 32120736 VBIEscCol129921_2765 # PDB 1H75 X-ray; 1.70 A; A=1-81 # PIR S70891 S70891 # PROSITE PS51354 GLUTAREDOXIN_2 # Pfam PF00462 Glutaredoxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NRDH_ECOLI Glutaredoxin-like protein NrdH # RefSeq NP_417159 NC_000913.3 # RefSeq WP_001223227 NZ_LN832404.1 # SIMILARITY Belongs to the glutaredoxin family. {ECO 0000305}. # SIMILARITY Contains 1 glutaredoxin domain. {ECO:0000255|PROSITE- ProRule PRU00686}. # SUPFAM SSF52833 SSF52833 # TIGRFAMs TIGR02194 GlrX_NrdH # eggNOG COG0695 LUCA # eggNOG ENOG4105WAZ Bacteria BLAST swissprot:NRDH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NRDH_ECOLI BioCyc ECOL316407:JW2648-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2648-MONOMER BioCyc EcoCyc:G7401-MONOMER http://biocyc.org/getid?id=EcoCyc:G7401-MONOMER COG COG0695 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0695 DIP DIP-48164N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48164N DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1996.424950.x http://dx.doi.org/10.1046/j.1365-2958.1996.424950.x DOI 10.1074/jbc.M105094200 http://dx.doi.org/10.1074/jbc.M105094200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X79787 http://www.ebi.ac.uk/ena/data/view/X79787 EchoBASE EB3071 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3071 EcoGene EG13286 http://www.ecogene.org/geneInfo.php?eg_id=EG13286 EnsemblBacteria AAC75720 http://www.ensemblgenomes.org/id/AAC75720 EnsemblBacteria AAC75720 http://www.ensemblgenomes.org/id/AAC75720 EnsemblBacteria BAE76782 http://www.ensemblgenomes.org/id/BAE76782 EnsemblBacteria BAE76782 http://www.ensemblgenomes.org/id/BAE76782 EnsemblBacteria BAE76782 http://www.ensemblgenomes.org/id/BAE76782 EnsemblBacteria b2673 http://www.ensemblgenomes.org/id/b2673 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005623 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005623 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0015035 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015035 GO_process GO:0045454 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045454 GO_process GO:0051353 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051353 GOslim_component GO:0005623 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005623 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 Gene3D 3.40.30.10 http://www.cathdb.info/version/latest/superfamily/3.40.30.10 GeneID 947161 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947161 HOGENOM HOG000095206 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000095206&db=HOGENOM6 InParanoid P0AC65 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AC65 IntAct P0AC65 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AC65* InterPro IPR002109 http://www.ebi.ac.uk/interpro/entry/IPR002109 InterPro IPR011909 http://www.ebi.ac.uk/interpro/entry/IPR011909 InterPro IPR012336 http://www.ebi.ac.uk/interpro/entry/IPR012336 KEGG_Gene ecj:JW2648 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2648 KEGG_Gene eco:b2673 http://www.genome.jp/dbget-bin/www_bget?eco:b2673 KEGG_Orthology KO:K06191 http://www.genome.jp/dbget-bin/www_bget?KO:K06191 OMA EQHWAGF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EQHWAGF PDB 1H75 http://www.ebi.ac.uk/pdbe-srv/view/entry/1H75 PDBsum 1H75 http://www.ebi.ac.uk/pdbsum/1H75 PROSITE PS51354 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51354 PSORT swissprot:NRDH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NRDH_ECOLI PSORT-B swissprot:NRDH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NRDH_ECOLI PSORT2 swissprot:NRDH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NRDH_ECOLI Pfam PF00462 http://pfam.xfam.org/family/PF00462 Phobius swissprot:NRDH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NRDH_ECOLI PhylomeDB P0AC65 http://phylomedb.org/?seqid=P0AC65 ProteinModelPortal P0AC65 http://www.proteinmodelportal.org/query/uniprot/P0AC65 PubMed 11441020 http://www.ncbi.nlm.nih.gov/pubmed/11441020 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 8820648 http://www.ncbi.nlm.nih.gov/pubmed/8820648 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417159 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417159 RefSeq WP_001223227 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001223227 SMR P0AC65 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AC65 STRING 511145.b2673 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2673&targetmode=cogs STRING COG0695 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0695&targetmode=cogs SUPFAM SSF52833 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52833 TIGRFAMs TIGR02194 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02194 UniProtKB NRDH_ECOLI http://www.uniprot.org/uniprot/NRDH_ECOLI UniProtKB-AC P0AC65 http://www.uniprot.org/uniprot/P0AC65 charge swissprot:NRDH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NRDH_ECOLI eggNOG COG0695 http://eggnogapi.embl.de/nog_data/html/tree/COG0695 eggNOG ENOG4105WAZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105WAZ epestfind swissprot:NRDH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NRDH_ECOLI garnier swissprot:NRDH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NRDH_ECOLI helixturnhelix swissprot:NRDH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NRDH_ECOLI hmoment swissprot:NRDH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NRDH_ECOLI iep swissprot:NRDH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NRDH_ECOLI inforesidue swissprot:NRDH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NRDH_ECOLI octanol swissprot:NRDH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NRDH_ECOLI pepcoil swissprot:NRDH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NRDH_ECOLI pepdigest swissprot:NRDH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NRDH_ECOLI pepinfo swissprot:NRDH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NRDH_ECOLI pepnet swissprot:NRDH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NRDH_ECOLI pepstats swissprot:NRDH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NRDH_ECOLI pepwheel swissprot:NRDH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NRDH_ECOLI pepwindow swissprot:NRDH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NRDH_ECOLI sigcleave swissprot:NRDH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NRDH_ECOLI ## Database ID URL or Descriptions # BioGrid 4261658 9 # DISRUPTION PHENOTYPE Cell viability is dramatically reduced in stationary phase, cells have a 10 hour growth block upon transition from rich to poor medium. Protein translation in stationary phase is derepressed. {ECO:0000269|PubMed 22829778}. # EcoGene EG11255 rsfS # FUNCTION IOJAP_ECOLI Functions as a ribosomal silencing factor. Addition to isolated ribosomal subunits partially inhibits their association, preventing translation. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8, preventing association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. {ECO 0000269|PubMed 22829778}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0043023 ribosomal large subunit binding; IDA:EcoCyc. # GO_process GO:0017148 negative regulation of translation; IDA:UniProtKB. # GO_process GO:0042256 mature ribosome assembly; IEA:UniProtKB-HAMAP. # GO_process GO:0090071 negative regulation of ribosome biogenesis; IDA:UniProtKB. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0008150 biological_process # GOslim_process GO:0022618 ribonucleoprotein complex assembly # HAMAP MF_01477 Iojap_RsfS # IntAct P0AAT6 10 # InterPro IPR004394 Iojap/RsfS/C7orf30 # KEGG_Brite ko03009 Ribosome biogenesis # Organism IOJAP_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21043 PTHR21043 # PATRIC 32116457 VBIEscCol129921_0668 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName IOJAP_ECOLI Ribosomal silencing factor RsfS # RefSeq NP_415170 NC_000913.3 # RefSeq WP_001161664 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA28199.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the Iojap/RsfS family. {ECO 0000305}. # SUBCELLULAR LOCATION IOJAP_ECOLI Cytoplasm {ECO 0000269|PubMed 16980477}. Note=Comigrates with the 50S ribosomal subunit in sucrose gradients, specifically with ribosomal protein L14 (rplN). # SUBUNIT Interacts with ribosomal protein L14 (rplN). {ECO:0000269|PubMed 22829778}. # TIGRFAMs TIGR00090 rsfS_iojap_ybeB # eggNOG COG0799 LUCA # eggNOG ENOG4105KEM Bacteria BLAST swissprot:IOJAP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:IOJAP_ECOLI BioCyc ECOL316407:JW5090-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5090-MONOMER BioCyc EcoCyc:EG11255-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11255-MONOMER COG COG0799 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0799 DIP DIP-48141N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48141N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1432-1033.1986.tb09961.x http://dx.doi.org/10.1111/j.1432-1033.1986.tb09961.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00444-06 http://dx.doi.org/10.1128/JB.00444-06 DOI 10.1371/journal.pgen.1002815 http://dx.doi.org/10.1371/journal.pgen.1002815 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EMBL X04516 http://www.ebi.ac.uk/ena/data/view/X04516 EchoBASE EB1235 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1235 EcoGene EG11255 http://www.ecogene.org/geneInfo.php?eg_id=EG11255 EnsemblBacteria AAC73738 http://www.ensemblgenomes.org/id/AAC73738 EnsemblBacteria AAC73738 http://www.ensemblgenomes.org/id/AAC73738 EnsemblBacteria BAA35284 http://www.ensemblgenomes.org/id/BAA35284 EnsemblBacteria BAA35284 http://www.ensemblgenomes.org/id/BAA35284 EnsemblBacteria BAA35284 http://www.ensemblgenomes.org/id/BAA35284 EnsemblBacteria b0637 http://www.ensemblgenomes.org/id/b0637 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0043023 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043023 GO_process GO:0017148 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017148 GO_process GO:0042256 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042256 GO_process GO:0090071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090071 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0022618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022618 GeneID 945237 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945237 HAMAP MF_01477 http://hamap.expasy.org/unirule/MF_01477 HOGENOM HOG000016051 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000016051&db=HOGENOM6 InParanoid P0AAT6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAT6 IntAct P0AAT6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAT6* InterPro IPR004394 http://www.ebi.ac.uk/interpro/entry/IPR004394 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW5090 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5090 KEGG_Gene eco:b0637 http://www.genome.jp/dbget-bin/www_bget?eco:b0637 KEGG_Orthology KO:K09710 http://www.genome.jp/dbget-bin/www_bget?KO:K09710 MINT MINT-1226369 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1226369 OMA HGNSDTQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HGNSDTQ PANTHER PTHR21043 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21043 PSORT swissprot:IOJAP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:IOJAP_ECOLI PSORT-B swissprot:IOJAP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:IOJAP_ECOLI PSORT2 swissprot:IOJAP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:IOJAP_ECOLI Phobius swissprot:IOJAP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:IOJAP_ECOLI PhylomeDB P0AAT6 http://phylomedb.org/?seqid=P0AAT6 ProteinModelPortal P0AAT6 http://www.proteinmodelportal.org/query/uniprot/P0AAT6 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16980477 http://www.ncbi.nlm.nih.gov/pubmed/16980477 PubMed 22829778 http://www.ncbi.nlm.nih.gov/pubmed/22829778 PubMed 3533535 http://www.ncbi.nlm.nih.gov/pubmed/3533535 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415170 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415170 RefSeq WP_001161664 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001161664 SMR P0AAT6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAT6 STRING 511145.b0637 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0637&targetmode=cogs STRING COG0799 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0799&targetmode=cogs TIGRFAMs TIGR00090 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00090 UniProtKB IOJAP_ECOLI http://www.uniprot.org/uniprot/IOJAP_ECOLI UniProtKB-AC P0AAT6 http://www.uniprot.org/uniprot/P0AAT6 charge swissprot:IOJAP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:IOJAP_ECOLI eggNOG COG0799 http://eggnogapi.embl.de/nog_data/html/tree/COG0799 eggNOG ENOG4105KEM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KEM epestfind swissprot:IOJAP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:IOJAP_ECOLI garnier swissprot:IOJAP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:IOJAP_ECOLI helixturnhelix swissprot:IOJAP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:IOJAP_ECOLI hmoment swissprot:IOJAP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:IOJAP_ECOLI iep swissprot:IOJAP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:IOJAP_ECOLI inforesidue swissprot:IOJAP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:IOJAP_ECOLI octanol swissprot:IOJAP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:IOJAP_ECOLI pepcoil swissprot:IOJAP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:IOJAP_ECOLI pepdigest swissprot:IOJAP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:IOJAP_ECOLI pepinfo swissprot:IOJAP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:IOJAP_ECOLI pepnet swissprot:IOJAP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:IOJAP_ECOLI pepstats swissprot:IOJAP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:IOJAP_ECOLI pepwheel swissprot:IOJAP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:IOJAP_ECOLI pepwindow swissprot:IOJAP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:IOJAP_ECOLI sigcleave swissprot:IOJAP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:IOJAP_ECOLI ## Database ID URL or Descriptions # BioGrid 4261042 373 # EcoGene EG10324 fliN # FUNCTION FLIN_ECOLI FliN is one of three proteins (FliG, FliN, FliM) that form a switch complex that is proposed to be located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0009425 bacterial-type flagellum basal body; IEA:UniProtKB-SubCell. # GO_function GO:0003774 motor activity; IEA:InterPro. # GO_process GO:0006935 chemotaxis; IEA:UniProtKB-KW. # GO_process GO:0071973 bacterial-type flagellum-dependent cell motility; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0040011 locomotion # GOslim_process GO:0048870 cell motility # INTERACTION FLIN_ECOLI P06974 fliM; NbExp=7; IntAct=EBI-2011987, EBI-560439; # IntAct P15070 10 # InterPro IPR001172 FliN_T3SS_HrcQb # InterPro IPR001543 SpoA # InterPro IPR012826 FliN # InterPro IPR031576 FliN_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko02030 Bacterial chemotaxis # KEGG_Pathway ko02040 Flagellar assembly # Organism FLIN_ECOLI Escherichia coli (strain K12) # PATRIC 32119221 VBIEscCol129921_2025 # PIR JS0111 XMECII # PRINTS PR00956 FLGMOTORFLIN # Pfam PF01052 FliMN_C # Pfam PF16973 FliN_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FLIN_ECOLI Flagellar motor switch protein FliN # RefSeq NP_416456 NC_000913.3 # RefSeq WP_001282101 NZ_LN832404.1 # SIMILARITY Belongs to the FliN/MopA/SpaO family. {ECO 0000305}. # SUBCELLULAR LOCATION FLIN_ECOLI Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Bacterial flagellum basal body. # SUPFAM SSF101801 SSF101801 # TIGRFAMs TIGR02480 fliN # eggNOG COG1886 LUCA # eggNOG ENOG4105DD5 Bacteria BLAST swissprot:FLIN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLIN_ECOLI BioCyc ECOL316407:JW1930-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1930-MONOMER BioCyc EcoCyc:FLIN-FLAGELLAR-C-RING-SWITCH http://biocyc.org/getid?id=EcoCyc:FLIN-FLAGELLAR-C-RING-SWITCH COG COG1886 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1886 DIP DIP-1101N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-1101N DOI 10.1016/S1937-6448(08)01402-0 http://dx.doi.org/10.1016/S1937-6448(08)01402-0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M26294 http://www.ebi.ac.uk/ena/data/view/M26294 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0320 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0320 EcoGene EG10324 http://www.ecogene.org/geneInfo.php?eg_id=EG10324 EnsemblBacteria AAC75013 http://www.ensemblgenomes.org/id/AAC75013 EnsemblBacteria AAC75013 http://www.ensemblgenomes.org/id/AAC75013 EnsemblBacteria BAA15771 http://www.ensemblgenomes.org/id/BAA15771 EnsemblBacteria BAA15771 http://www.ensemblgenomes.org/id/BAA15771 EnsemblBacteria BAA15771 http://www.ensemblgenomes.org/id/BAA15771 EnsemblBacteria b1946 http://www.ensemblgenomes.org/id/b1946 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0009425 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009425 GO_function GO:0003774 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003774 GO_process GO:0006935 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006935 GO_process GO:0071973 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071973 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0040011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 GeneID 946423 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946423 HOGENOM HOG000253569 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000253569&db=HOGENOM6 InParanoid P15070 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P15070 IntAct P15070 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P15070* InterPro IPR001172 http://www.ebi.ac.uk/interpro/entry/IPR001172 InterPro IPR001543 http://www.ebi.ac.uk/interpro/entry/IPR001543 InterPro IPR012826 http://www.ebi.ac.uk/interpro/entry/IPR012826 InterPro IPR031576 http://www.ebi.ac.uk/interpro/entry/IPR031576 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW1930 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1930 KEGG_Gene eco:b1946 http://www.genome.jp/dbget-bin/www_bget?eco:b1946 KEGG_Orthology KO:K02417 http://www.genome.jp/dbget-bin/www_bget?KO:K02417 KEGG_Pathway ko02030 http://www.genome.jp/kegg-bin/show_pathway?ko02030 KEGG_Pathway ko02040 http://www.genome.jp/kegg-bin/show_pathway?ko02040 OMA MWADAMS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MWADAMS PRINTS PR00956 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00956 PSORT swissprot:FLIN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLIN_ECOLI PSORT-B swissprot:FLIN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLIN_ECOLI PSORT2 swissprot:FLIN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLIN_ECOLI Pfam PF01052 http://pfam.xfam.org/family/PF01052 Pfam PF16973 http://pfam.xfam.org/family/PF16973 Phobius swissprot:FLIN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLIN_ECOLI PhylomeDB P15070 http://phylomedb.org/?seqid=P15070 ProteinModelPortal P15070 http://www.proteinmodelportal.org/query/uniprot/P15070 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19081534 http://www.ncbi.nlm.nih.gov/pubmed/19081534 PubMed 2651416 http://www.ncbi.nlm.nih.gov/pubmed/2651416 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416456 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416456 RefSeq WP_001282101 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001282101 SMR P15070 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P15070 STRING 511145.b1946 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1946&targetmode=cogs STRING COG1886 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1886&targetmode=cogs SUPFAM SSF101801 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF101801 TIGRFAMs TIGR02480 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02480 UniProtKB FLIN_ECOLI http://www.uniprot.org/uniprot/FLIN_ECOLI UniProtKB-AC P15070 http://www.uniprot.org/uniprot/P15070 charge swissprot:FLIN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLIN_ECOLI eggNOG COG1886 http://eggnogapi.embl.de/nog_data/html/tree/COG1886 eggNOG ENOG4105DD5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DD5 epestfind swissprot:FLIN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLIN_ECOLI garnier swissprot:FLIN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLIN_ECOLI helixturnhelix swissprot:FLIN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLIN_ECOLI hmoment swissprot:FLIN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLIN_ECOLI iep swissprot:FLIN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLIN_ECOLI inforesidue swissprot:FLIN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLIN_ECOLI octanol swissprot:FLIN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLIN_ECOLI pepcoil swissprot:FLIN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLIN_ECOLI pepdigest swissprot:FLIN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLIN_ECOLI pepinfo swissprot:FLIN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLIN_ECOLI pepnet swissprot:FLIN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLIN_ECOLI pepstats swissprot:FLIN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLIN_ECOLI pepwheel swissprot:FLIN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLIN_ECOLI pepwindow swissprot:FLIN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLIN_ECOLI sigcleave swissprot:FLIN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLIN_ECOLI ## Database ID URL or Descriptions # AltName NFRB_ECOLI Bacteriophage N4 adsorption protein B # BioGrid 4262937 95 # EcoGene EG11739 nfrB # FUNCTION NFRB_ECOLI Required for bacteriophage N4 adsorption. May be a component of the phage receptor. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005524 ATP binding; IEA:InterPro. # GO_process GO:0006810 transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # IntAct P0AFA5 2 # InterPro IPR001173 Glyco_trans_2-like # InterPro IPR007831 GSPII_E_N # InterPro IPR029044 Nucleotide-diphossugar_trans # Organism NFRB_ECOLI Escherichia coli (strain K12) # PATRIC 32116306 VBIEscCol129921_0593 # PIR A49351 A49351 # Pfam PF05157 T2SSE_N # Pfam PF13632 Glyco_trans_2_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Bacteriophage adsorption protein B {ECO 0000305} # RefSeq NP_415101 NC_000913.3 # RefSeq WP_000383932 NZ_LN832404.1 # SUBCELLULAR LOCATION NFRB_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # SUPFAM SSF53448 SSF53448 # eggNOG ENOG410802X Bacteria # eggNOG ENOG410YBKS LUCA BLAST swissprot:NFRB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NFRB_ECOLI BioCyc ECOL316407:JW0558-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0558-MONOMER BioCyc EcoCyc:EG11739-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11739-MONOMER DIP DIP-10333N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10333N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L16945 http://www.ebi.ac.uk/ena/data/view/L16945 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB1690 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1690 EcoGene EG11739 http://www.ecogene.org/geneInfo.php?eg_id=EG11739 EnsemblBacteria AAC73670 http://www.ensemblgenomes.org/id/AAC73670 EnsemblBacteria AAC73670 http://www.ensemblgenomes.org/id/AAC73670 EnsemblBacteria BAA35203 http://www.ensemblgenomes.org/id/BAA35203 EnsemblBacteria BAA35203 http://www.ensemblgenomes.org/id/BAA35203 EnsemblBacteria BAA35203 http://www.ensemblgenomes.org/id/BAA35203 EnsemblBacteria b0569 http://www.ensemblgenomes.org/id/b0569 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 945849 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945849 HOGENOM HOG000117834 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117834&db=HOGENOM6 IntAct P0AFA5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFA5* InterPro IPR001173 http://www.ebi.ac.uk/interpro/entry/IPR001173 InterPro IPR007831 http://www.ebi.ac.uk/interpro/entry/IPR007831 InterPro IPR029044 http://www.ebi.ac.uk/interpro/entry/IPR029044 KEGG_Gene ecj:JW0558 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0558 KEGG_Gene eco:b0569 http://www.genome.jp/dbget-bin/www_bget?eco:b0569 KEGG_Orthology KO:K11740 http://www.genome.jp/dbget-bin/www_bget?KO:K11740 MINT MINT-1320212 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1320212 OMA KTMHDFP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KTMHDFP PSORT swissprot:NFRB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NFRB_ECOLI PSORT-B swissprot:NFRB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NFRB_ECOLI PSORT2 swissprot:NFRB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NFRB_ECOLI Pfam PF05157 http://pfam.xfam.org/family/PF05157 Pfam PF13632 http://pfam.xfam.org/family/PF13632 Phobius swissprot:NFRB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NFRB_ECOLI ProteinModelPortal P0AFA5 http://www.proteinmodelportal.org/query/uniprot/P0AFA5 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8226649 http://www.ncbi.nlm.nih.gov/pubmed/8226649 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415101 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415101 RefSeq WP_000383932 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000383932 STRING 511145.b0569 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0569&targetmode=cogs SUPFAM SSF53448 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53448 UniProtKB NFRB_ECOLI http://www.uniprot.org/uniprot/NFRB_ECOLI UniProtKB-AC P0AFA5 http://www.uniprot.org/uniprot/P0AFA5 charge swissprot:NFRB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NFRB_ECOLI eggNOG ENOG410802X http://eggnogapi.embl.de/nog_data/html/tree/ENOG410802X eggNOG ENOG410YBKS http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YBKS epestfind swissprot:NFRB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NFRB_ECOLI garnier swissprot:NFRB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NFRB_ECOLI helixturnhelix swissprot:NFRB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NFRB_ECOLI hmoment swissprot:NFRB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NFRB_ECOLI iep swissprot:NFRB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NFRB_ECOLI inforesidue swissprot:NFRB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NFRB_ECOLI octanol swissprot:NFRB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NFRB_ECOLI pepcoil swissprot:NFRB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NFRB_ECOLI pepdigest swissprot:NFRB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NFRB_ECOLI pepinfo swissprot:NFRB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NFRB_ECOLI pepnet swissprot:NFRB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NFRB_ECOLI pepstats swissprot:NFRB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NFRB_ECOLI pepwheel swissprot:NFRB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NFRB_ECOLI pepwindow swissprot:NFRB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NFRB_ECOLI sigcleave swissprot:NFRB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NFRB_ECOLI ## Database ID URL or Descriptions # BioGrid 4263329 5 # CATALYTIC ACTIVITY ILVD_ECOLI 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2- oxobutanoate + H(2)O. {ECO 0000255|HAMAP-Rule MF_00012, ECO 0000269|PubMed 7771772, ECO 0000269|PubMed 8325851}. # COFACTOR ILVD_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000255|HAMAP-Rule MF_00012, ECO 0000269|PubMed 7771772, ECO 0000269|PubMed 8325851}; Note=Binds 1 [4Fe-4S] cluster. {ECO 0000255|HAMAP-Rule MF_00012, ECO 0000269|PubMed 7771772, ECO 0000269|PubMed 8325851}; # EcoGene EG10496 ilvD # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004160 dihydroxy-acid dehydratase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051536 iron-sulfur cluster binding; IDA:EcoCyc. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IDA:EcoCyc. # GO_process GO:0009097 isoleucine biosynthetic process; IDA:EcoCyc. # GO_process GO:0009099 valine biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # HAMAP MF_00012 IlvD # InterPro IPR000581 DiOHA_6PGluconate_deHydtase # InterPro IPR004404 DihydroxyA_deHydtase # InterPro IPR015928 Aconitase/3IPM_dehydase_swvl # InterPro IPR020558 DiOHA_6PGluconate_deHydtase_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00290 Valine, leucine and isoleucine biosynthesis # KEGG_Pathway ko00770 Pantothenate and CoA biosynthesis # Organism ILVD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21000 PTHR21000; 2 # PATHWAY ILVD_ECOLI Amino-acid biosynthesis; L-isoleucine biosynthesis; L- isoleucine from 2-oxobutanoate step 3/4. {ECO 0000255|HAMAP- Rule MF_00012, ECO 0000269|PubMed 3550695}. # PATHWAY ILVD_ECOLI Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate step 3/4. {ECO 0000255|HAMAP-Rule MF_00012, ECO 0000269|PubMed 3550695}. # PATRIC 32123037 VBIEscCol129921_3888 # PIR A27310 DWECDA # PROSITE PS00886 ILVD_EDD_1 # PROSITE PS00887 ILVD_EDD_2 # Pfam PF00920 ILVD_EDD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Dihydroxy-acid dehydratase {ECO:0000255|HAMAP-Rule MF_00012} # RefSeq WP_001127399 NZ_LN832404.1 # RefSeq YP_026248 NC_000913.3 # SIMILARITY Belongs to the IlvD/Edd family. {ECO:0000255|HAMAP- Rule MF_00012}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 8325851}. # SUPFAM SSF52016 SSF52016 # TIGRFAMs TIGR00110 ilvD # UniPathway UPA00047 UER00057 # UniPathway UPA00049 UER00061 # eggNOG COG0129 LUCA # eggNOG ENOG4105C01 Bacteria BLAST swissprot:ILVD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ILVD_ECOLI BioCyc ECOL316407:JW5605-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5605-MONOMER BioCyc EcoCyc:DIHYDROXYACIDDEHYDRAT-MONOMER http://biocyc.org/getid?id=EcoCyc:DIHYDROXYACIDDEHYDRAT-MONOMER BioCyc MetaCyc:DIHYDROXYACIDDEHYDRAT-MONOMER http://biocyc.org/getid?id=MetaCyc:DIHYDROXYACIDDEHYDRAT-MONOMER COG COG0129 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0129 DIP DIP-10021N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10021N DOI 10.1006/abbi.1995.1262 http://dx.doi.org/10.1006/abbi.1995.1262 DOI 10.1016/0378-1119(87)90136-3 http://dx.doi.org/10.1016/0378-1119(87)90136-3 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/15.5.2137 http://dx.doi.org/10.1093/nar/15.5.2137 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.1.9 {ECO:0000255|HAMAP-Rule:MF_00012} http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.9 {ECO:0000255|HAMAP-Rule:MF_00012} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K03503 http://www.ebi.ac.uk/ena/data/view/K03503 EMBL M10313 http://www.ebi.ac.uk/ena/data/view/M10313 EMBL M32253 http://www.ebi.ac.uk/ena/data/view/M32253 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X02413 http://www.ebi.ac.uk/ena/data/view/X02413 EMBL X04890 http://www.ebi.ac.uk/ena/data/view/X04890 ENZYME 4.2.1.9 {ECO:0000255|HAMAP-Rule:MF_00012} http://enzyme.expasy.org/EC/4.2.1.9 {ECO:0000255|HAMAP-Rule:MF_00012} EchoBASE EB0491 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0491 EcoGene EG10496 http://www.ecogene.org/geneInfo.php?eg_id=EG10496 EnsemblBacteria AAT48208 http://www.ensemblgenomes.org/id/AAT48208 EnsemblBacteria AAT48208 http://www.ensemblgenomes.org/id/AAT48208 EnsemblBacteria BAE77526 http://www.ensemblgenomes.org/id/BAE77526 EnsemblBacteria BAE77526 http://www.ensemblgenomes.org/id/BAE77526 EnsemblBacteria BAE77526 http://www.ensemblgenomes.org/id/BAE77526 EnsemblBacteria b3771 http://www.ensemblgenomes.org/id/b3771 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004160 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051536 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051536 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0009097 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009097 GO_process GO:0009099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009099 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 948277 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948277 HAMAP MF_00012 http://hamap.expasy.org/unirule/MF_00012 HOGENOM HOG000173155 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000173155&db=HOGENOM6 InParanoid P05791 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P05791 IntAct P05791 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P05791* IntEnz 4.2.1.9 {ECO:0000255|HAMAP-Rule:MF_00012} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.9 {ECO:0000255|HAMAP-Rule:MF_00012} InterPro IPR000581 http://www.ebi.ac.uk/interpro/entry/IPR000581 InterPro IPR004404 http://www.ebi.ac.uk/interpro/entry/IPR004404 InterPro IPR015928 http://www.ebi.ac.uk/interpro/entry/IPR015928 InterPro IPR020558 http://www.ebi.ac.uk/interpro/entry/IPR020558 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5605 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5605 KEGG_Gene eco:b3771 http://www.genome.jp/dbget-bin/www_bget?eco:b3771 KEGG_Orthology KO:K01687 http://www.genome.jp/dbget-bin/www_bget?KO:K01687 KEGG_Pathway ko00290 http://www.genome.jp/kegg-bin/show_pathway?ko00290 KEGG_Pathway ko00770 http://www.genome.jp/kegg-bin/show_pathway?ko00770 KEGG_Reaction rn:R01209 http://www.genome.jp/dbget-bin/www_bget?rn:R01209 KEGG_Reaction rn:R04441 http://www.genome.jp/dbget-bin/www_bget?rn:R04441 KEGG_Reaction rn:R05070 http://www.genome.jp/dbget-bin/www_bget?rn:R05070 MINT MINT-1302071 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1302071 OMA QGRNMAG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QGRNMAG PANTHER PTHR21000 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21000 PROSITE PS00886 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00886 PROSITE PS00887 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00887 PSORT swissprot:ILVD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ILVD_ECOLI PSORT-B swissprot:ILVD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ILVD_ECOLI PSORT2 swissprot:ILVD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ILVD_ECOLI Pfam PF00920 http://pfam.xfam.org/family/PF00920 Phobius swissprot:ILVD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ILVD_ECOLI PhylomeDB P05791 http://phylomedb.org/?seqid=P05791 ProteinModelPortal P05791 http://www.proteinmodelportal.org/query/uniprot/P05791 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3315862 http://www.ncbi.nlm.nih.gov/pubmed/3315862 PubMed 3550695 http://www.ncbi.nlm.nih.gov/pubmed/3550695 PubMed 3897211 http://www.ncbi.nlm.nih.gov/pubmed/3897211 PubMed 7771772 http://www.ncbi.nlm.nih.gov/pubmed/7771772 PubMed 8325851 http://www.ncbi.nlm.nih.gov/pubmed/8325851 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001127399 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001127399 RefSeq YP_026248 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026248 STRING 511145.b3771 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3771&targetmode=cogs STRING COG0129 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0129&targetmode=cogs SUPFAM SSF52016 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52016 SWISS-2DPAGE P05791 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P05791 TIGRFAMs TIGR00110 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00110 UniProtKB ILVD_ECOLI http://www.uniprot.org/uniprot/ILVD_ECOLI UniProtKB-AC P05791 http://www.uniprot.org/uniprot/P05791 charge swissprot:ILVD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ILVD_ECOLI eggNOG COG0129 http://eggnogapi.embl.de/nog_data/html/tree/COG0129 eggNOG ENOG4105C01 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C01 epestfind swissprot:ILVD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ILVD_ECOLI garnier swissprot:ILVD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ILVD_ECOLI helixturnhelix swissprot:ILVD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ILVD_ECOLI hmoment swissprot:ILVD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ILVD_ECOLI iep swissprot:ILVD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ILVD_ECOLI inforesidue swissprot:ILVD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ILVD_ECOLI octanol swissprot:ILVD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ILVD_ECOLI pepcoil swissprot:ILVD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ILVD_ECOLI pepdigest swissprot:ILVD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ILVD_ECOLI pepinfo swissprot:ILVD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ILVD_ECOLI pepnet swissprot:ILVD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ILVD_ECOLI pepstats swissprot:ILVD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ILVD_ECOLI pepwheel swissprot:ILVD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ILVD_ECOLI pepwindow swissprot:ILVD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ILVD_ECOLI sigcleave swissprot:ILVD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ILVD_ECOLI ## Database ID URL or Descriptions # BioGrid 4263353 10 # EcoGene EG13759 ydcP # GO_function GO:0008233 peptidase activity; IEA:UniProtKB-KW. # GOslim_function GO:0008233 peptidase activity # INTERACTION YDCP_ECOLI P05824 recN; NbExp=2; IntAct=EBI-556974, EBI-548098; # IntAct P76104 50 # InterPro IPR001539 Peptidase_U32 # InterPro IPR020988 Pept_U32_collagenase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # KEGG_Pathway ko05120 Epithelial cell signaling in Helicobacter pylori infection # Organism YDCP_ECOLI Escherichia coli (strain K12) # PATRIC 32118160 VBIEscCol129921_1500 # PROSITE PS01276 PEPTIDASE_U32 # Pfam PF01136 Peptidase_U32 # Pfam PF12392 DUF3656 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDCP_ECOLI Uncharacterized protease YdcP # RefSeq NP_415952 NC_000913.3 # RefSeq WP_001303492 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase U32 family. {ECO 0000305}. # eggNOG COG0826 LUCA # eggNOG ENOG4105CFP Bacteria BLAST swissprot:YDCP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDCP_ECOLI BioCyc ECOL316407:JW1431-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1431-MONOMER BioCyc EcoCyc:G6746-MONOMER http://biocyc.org/getid?id=EcoCyc:G6746-MONOMER COG COG0826 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0826 DIP DIP-11650N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11650N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.4.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.4.-.- http://enzyme.expasy.org/EC/3.4.-.- EchoBASE EB3522 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3522 EcoGene EG13759 http://www.ecogene.org/geneInfo.php?eg_id=EG13759 EnsemblBacteria AAC74517 http://www.ensemblgenomes.org/id/AAC74517 EnsemblBacteria AAC74517 http://www.ensemblgenomes.org/id/AAC74517 EnsemblBacteria BAA15068 http://www.ensemblgenomes.org/id/BAA15068 EnsemblBacteria BAA15068 http://www.ensemblgenomes.org/id/BAA15068 EnsemblBacteria BAA15068 http://www.ensemblgenomes.org/id/BAA15068 EnsemblBacteria b1435 http://www.ensemblgenomes.org/id/b1435 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GeneID 945993 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945993 HOGENOM HOG000273229 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000273229&db=HOGENOM6 InParanoid P76104 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76104 IntAct P76104 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76104* IntEnz 3.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4 InterPro IPR001539 http://www.ebi.ac.uk/interpro/entry/IPR001539 InterPro IPR020988 http://www.ebi.ac.uk/interpro/entry/IPR020988 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW1431 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1431 KEGG_Gene eco:b1435 http://www.genome.jp/dbget-bin/www_bget?eco:b1435 KEGG_Orthology KO:K08303 http://www.genome.jp/dbget-bin/www_bget?KO:K08303 KEGG_Pathway ko05120 http://www.genome.jp/kegg-bin/show_pathway?ko05120 MINT MINT-1229370 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1229370 OMA SGQCNIS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SGQCNIS PROSITE PS01276 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01276 PSORT swissprot:YDCP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDCP_ECOLI PSORT-B swissprot:YDCP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDCP_ECOLI PSORT2 swissprot:YDCP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDCP_ECOLI Pfam PF01136 http://pfam.xfam.org/family/PF01136 Pfam PF12392 http://pfam.xfam.org/family/PF12392 Phobius swissprot:YDCP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDCP_ECOLI PhylomeDB P76104 http://phylomedb.org/?seqid=P76104 ProteinModelPortal P76104 http://www.proteinmodelportal.org/query/uniprot/P76104 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415952 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415952 RefSeq WP_001303492 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001303492 SMR P76104 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76104 STRING 511145.b1435 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1435&targetmode=cogs STRING COG0826 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0826&targetmode=cogs UniProtKB YDCP_ECOLI http://www.uniprot.org/uniprot/YDCP_ECOLI UniProtKB-AC P76104 http://www.uniprot.org/uniprot/P76104 charge swissprot:YDCP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDCP_ECOLI eggNOG COG0826 http://eggnogapi.embl.de/nog_data/html/tree/COG0826 eggNOG ENOG4105CFP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CFP epestfind swissprot:YDCP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDCP_ECOLI garnier swissprot:YDCP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDCP_ECOLI helixturnhelix swissprot:YDCP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDCP_ECOLI hmoment swissprot:YDCP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDCP_ECOLI iep swissprot:YDCP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDCP_ECOLI inforesidue swissprot:YDCP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDCP_ECOLI octanol swissprot:YDCP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDCP_ECOLI pepcoil swissprot:YDCP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDCP_ECOLI pepdigest swissprot:YDCP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDCP_ECOLI pepinfo swissprot:YDCP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDCP_ECOLI pepnet swissprot:YDCP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDCP_ECOLI pepstats swissprot:YDCP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDCP_ECOLI pepwheel swissprot:YDCP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDCP_ECOLI pepwindow swissprot:YDCP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDCP_ECOLI sigcleave swissprot:YDCP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDCP_ECOLI ## Database ID URL or Descriptions # BioGrid 4259159 39 # EcoGene EG13382 yeeN # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.200 -; 1. # Gene3D 3.30.1270.10 -; 2. # Gene3D 3.30.70.980 -; 1. # HAMAP MF_00693 Transcrip_reg_TACO1 # HAMAP MF_00918 Transcrip_reg_TACO1_YeeN # IntAct P0A8A2 22 # InterPro IPR002876 Transcrip_reg_TACO1-like # InterPro IPR017856 Integrase_Zn-bd_dom-like_N # InterPro IPR026562 Transcrip_reg_TACO1_YeeN # InterPro IPR026563 Transcrip_reg_TACO1-like_dom2 # InterPro IPR026564 Transcrip_reg_TACO1-like_dom3 # InterPro IPR029072 YebC-like # Organism YEEN_ECOLI Escherichia coli (strain K12) # PANTHER PTHR12532 PTHR12532 # PATRIC 32119297 VBIEscCol129921_2061 # PIR A64963 A64963 # Pfam PF01709 Transcrip_reg # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Probable transcriptional regulatory protein YeeN {ECO:0000255|HAMAP-Rule MF_00918} # RefSeq NP_416490 NC_000913.3 # RefSeq WP_000532923 NZ_LN832404.1 # SIMILARITY Belongs to the TACO1 family. YeeN subfamily. {ECO:0000255|HAMAP-Rule MF_00918}. # SUBCELLULAR LOCATION YEEN_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00918}. # SUPFAM SSF75625 SSF75625 # TIGRFAMs TIGR01033 TIGR01033 # eggNOG COG0217 LUCA # eggNOG ENOG4105CDY Bacteria BLAST swissprot:YEEN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEEN_ECOLI BioCyc ECOL316407:JW1964-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1964-MONOMER BioCyc EcoCyc:G7068-MONOMER http://biocyc.org/getid?id=EcoCyc:G7068-MONOMER DIP DIP-36184N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36184N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3163 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3163 EcoGene EG13382 http://www.ecogene.org/geneInfo.php?eg_id=EG13382 EnsemblBacteria AAC75047 http://www.ensemblgenomes.org/id/AAC75047 EnsemblBacteria AAC75047 http://www.ensemblgenomes.org/id/AAC75047 EnsemblBacteria BAA15803 http://www.ensemblgenomes.org/id/BAA15803 EnsemblBacteria BAA15803 http://www.ensemblgenomes.org/id/BAA15803 EnsemblBacteria BAA15803 http://www.ensemblgenomes.org/id/BAA15803 EnsemblBacteria b1983 http://www.ensemblgenomes.org/id/b1983 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.200 http://www.cathdb.info/version/latest/superfamily/1.10.10.200 Gene3D 3.30.1270.10 http://www.cathdb.info/version/latest/superfamily/3.30.1270.10 Gene3D 3.30.70.980 http://www.cathdb.info/version/latest/superfamily/3.30.70.980 GeneID 946493 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946493 HAMAP MF_00693 http://hamap.expasy.org/unirule/MF_00693 HAMAP MF_00918 http://hamap.expasy.org/unirule/MF_00918 HOGENOM HOG000228371 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000228371&db=HOGENOM6 InParanoid P0A8A2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8A2 IntAct P0A8A2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8A2* InterPro IPR002876 http://www.ebi.ac.uk/interpro/entry/IPR002876 InterPro IPR017856 http://www.ebi.ac.uk/interpro/entry/IPR017856 InterPro IPR026562 http://www.ebi.ac.uk/interpro/entry/IPR026562 InterPro IPR026563 http://www.ebi.ac.uk/interpro/entry/IPR026563 InterPro IPR026564 http://www.ebi.ac.uk/interpro/entry/IPR026564 InterPro IPR029072 http://www.ebi.ac.uk/interpro/entry/IPR029072 KEGG_Gene ecj:JW1964 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1964 KEGG_Gene eco:b1983 http://www.genome.jp/dbget-bin/www_bget?eco:b1983 OMA MKRWGNM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MKRWGNM PANTHER PTHR12532 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12532 PSORT swissprot:YEEN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEEN_ECOLI PSORT-B swissprot:YEEN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEEN_ECOLI PSORT2 swissprot:YEEN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEEN_ECOLI Pfam PF01709 http://pfam.xfam.org/family/PF01709 Phobius swissprot:YEEN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEEN_ECOLI PhylomeDB P0A8A2 http://phylomedb.org/?seqid=P0A8A2 ProteinModelPortal P0A8A2 http://www.proteinmodelportal.org/query/uniprot/P0A8A2 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416490 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416490 RefSeq WP_000532923 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000532923 SMR P0A8A2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8A2 STRING 511145.b1983 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1983&targetmode=cogs SUPFAM SSF75625 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF75625 TIGRFAMs TIGR01033 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01033 UniProtKB YEEN_ECOLI http://www.uniprot.org/uniprot/YEEN_ECOLI UniProtKB-AC P0A8A2 http://www.uniprot.org/uniprot/P0A8A2 charge swissprot:YEEN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEEN_ECOLI eggNOG COG0217 http://eggnogapi.embl.de/nog_data/html/tree/COG0217 eggNOG ENOG4105CDY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CDY epestfind swissprot:YEEN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEEN_ECOLI garnier swissprot:YEEN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEEN_ECOLI helixturnhelix swissprot:YEEN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEEN_ECOLI hmoment swissprot:YEEN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEEN_ECOLI iep swissprot:YEEN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEEN_ECOLI inforesidue swissprot:YEEN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEEN_ECOLI octanol swissprot:YEEN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEEN_ECOLI pepcoil swissprot:YEEN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEEN_ECOLI pepdigest swissprot:YEEN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEEN_ECOLI pepinfo swissprot:YEEN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEEN_ECOLI pepnet swissprot:YEEN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEEN_ECOLI pepstats swissprot:YEEN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEEN_ECOLI pepwheel swissprot:YEEN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEEN_ECOLI pepwindow swissprot:YEEN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEEN_ECOLI sigcleave swissprot:YEEN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEEN_ECOLI ## Database ID URL or Descriptions # BioGrid 4261677 138 # CATALYTIC ACTIVITY MDLA_ECOLI ATP + H(2)O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out). # EcoGene EG11622 mdlA # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0008559 xenobiotic-transporting ATPase activity; IEA:UniProtKB-EC. # GO_function GO:0034040 lipid-transporting ATPase activity; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.300 -; 1. # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR011527 ABC1_TM_dom # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko02000 Transporters # Organism MDLA_ECOLI Escherichia coli (strain K12) # PATRIC 32116049 VBIEscCol129921_0466 # PIR H64774 H64774 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # PROSITE PS50929 ABC_TM1F # Pfam PF00005 ABC_tran # Pfam PF00664 ABC_membrane # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MDLA_ECOLI Multidrug resistance-like ATP-binding protein MdlA # RefSeq NP_414982 NC_000913.3 # RefSeq WP_001235649 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAC36870.1; Type=Frameshift; Positions=546; Note=Fuses together mdlA and mdlB.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ABC transporter superfamily. Drug exporter-2 (TC 3.A.1.117) family. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA # SUBCELLULAR LOCATION MDLA_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00441, ECO 0000269|PubMed 15919996}. # SUPFAM SSF52540 SSF52540 # SUPFAM SSF90123 SSF90123 # TCDB 3.A.1.106.13 the atp-binding cassette (abc) superfamily # eggNOG COG1132 LUCA # eggNOG ENOG4105BZ1 Bacteria BLAST swissprot:MDLA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MDLA_ECOLI BioCyc ECOL316407:JW0438-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0438-MONOMER BioCyc EcoCyc:MDLA-MONOMER http://biocyc.org/getid?id=EcoCyc:MDLA-MONOMER COG COG1132 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1132 COG COG2274 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2274 COG COG5265 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG5265 DIP DIP-10173N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10173N DOI 10.1016/0378-1119(93)90470-N http://dx.doi.org/10.1016/0378-1119(93)90470-N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.3.44 http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.44 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L08627 http://www.ebi.ac.uk/ena/data/view/L08627 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 ENZYME 3.6.3.44 http://enzyme.expasy.org/EC/3.6.3.44 EchoBASE EB1579 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1579 EcoGene EG11622 http://www.ecogene.org/geneInfo.php?eg_id=EG11622 EnsemblBacteria AAC73551 http://www.ensemblgenomes.org/id/AAC73551 EnsemblBacteria AAC73551 http://www.ensemblgenomes.org/id/AAC73551 EnsemblBacteria BAE76228 http://www.ensemblgenomes.org/id/BAE76228 EnsemblBacteria BAE76228 http://www.ensemblgenomes.org/id/BAE76228 EnsemblBacteria BAE76228 http://www.ensemblgenomes.org/id/BAE76228 EnsemblBacteria b0448 http://www.ensemblgenomes.org/id/b0448 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008559 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008559 GO_function GO:0034040 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034040 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945092 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945092 InParanoid P77265 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77265 IntAct P77265 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77265* IntEnz 3.6.3.44 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.44 InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR011527 http://www.ebi.ac.uk/interpro/entry/IPR011527 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0438 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0438 KEGG_Gene eco:b0448 http://www.genome.jp/dbget-bin/www_bget?eco:b0448 KEGG_Orthology KO:K06147 http://www.genome.jp/dbget-bin/www_bget?KO:K06147 OMA SWRYTLG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SWRYTLG PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PROSITE PS50929 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50929 PSORT swissprot:MDLA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MDLA_ECOLI PSORT-B swissprot:MDLA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MDLA_ECOLI PSORT2 swissprot:MDLA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MDLA_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Pfam PF00664 http://pfam.xfam.org/family/PF00664 Phobius swissprot:MDLA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MDLA_ECOLI PhylomeDB P77265 http://phylomedb.org/?seqid=P77265 ProteinModelPortal P77265 http://www.proteinmodelportal.org/query/uniprot/P77265 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7904973 http://www.ncbi.nlm.nih.gov/pubmed/7904973 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414982 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414982 RefSeq WP_001235649 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001235649 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P77265 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77265 STRING 511145.b0448 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0448&targetmode=cogs STRING COG1132 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1132&targetmode=cogs STRING COG2274 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2274&targetmode=cogs STRING COG5265 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG5265&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SUPFAM SSF90123 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90123 TCDB 3.A.1.106.13 http://www.tcdb.org/search/result.php?tc=3.A.1.106.13 UniProtKB MDLA_ECOLI http://www.uniprot.org/uniprot/MDLA_ECOLI UniProtKB-AC P77265 http://www.uniprot.org/uniprot/P77265 charge swissprot:MDLA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MDLA_ECOLI eggNOG COG1132 http://eggnogapi.embl.de/nog_data/html/tree/COG1132 eggNOG ENOG4105BZ1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZ1 epestfind swissprot:MDLA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MDLA_ECOLI garnier swissprot:MDLA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MDLA_ECOLI helixturnhelix swissprot:MDLA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MDLA_ECOLI hmoment swissprot:MDLA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MDLA_ECOLI iep swissprot:MDLA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MDLA_ECOLI inforesidue swissprot:MDLA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MDLA_ECOLI octanol swissprot:MDLA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MDLA_ECOLI pepcoil swissprot:MDLA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MDLA_ECOLI pepdigest swissprot:MDLA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MDLA_ECOLI pepinfo swissprot:MDLA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MDLA_ECOLI pepnet swissprot:MDLA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MDLA_ECOLI pepstats swissprot:MDLA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MDLA_ECOLI pepwheel swissprot:MDLA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MDLA_ECOLI pepwindow swissprot:MDLA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MDLA_ECOLI sigcleave swissprot:MDLA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MDLA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261558 234 # EcoGene EG10296 fepD # FUNCTION FEPD_ECOLI Part of the binding-protein-dependent transport system for ferric enterobactin. Probably responsible for the translocation of the substrate across the membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; NAS:EcoCyc. # GO_function GO:0015620 ferric-enterobactin transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0015685 ferric-enterobactin transport; IMP:EcoCyc. # GO_process GO:0055072 iron ion homeostasis; IEA:UniProtKB-KW. # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0042592 homeostatic process # Gene3D 1.10.3470.10 -; 1. # INDUCTION Controlled in part by the amount of available iron. Induced by hydroxyurea (PubMed:20005847). {ECO 0000269|PubMed:20005847}. # InterPro IPR000522 ABC_transptr_FecCD # InterPro IPR029022 ABC_BtuC-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00240 Iron complex transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism FEPD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30472 PTHR30472 # PATRIC 32116356 VBIEscCol129921_0618 # PIR S16296 S16296 # Pfam PF01032 FecCD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FEPD_ECOLI Ferric enterobactin transport system permease protein FepD # RefSeq NP_415122 NC_000913.3 # RefSeq WP_000016947 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40789.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION FEPD_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF81345 SSF81345 # TCDB 3.A.1.14 the atp-binding cassette (abc) superfamily # eggNOG COG0609 LUCA # eggNOG ENOG4105DQ5 Bacteria BLAST swissprot:FEPD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FEPD_ECOLI BioCyc ECOL316407:JW0582-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0582-MONOMER BioCyc EcoCyc:FEPD-MONOMER http://biocyc.org/getid?id=EcoCyc:FEPD-MONOMER BioCyc MetaCyc:FEPD-MONOMER http://biocyc.org/getid?id=MetaCyc:FEPD-MONOMER COG COG0609 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0609 DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1991.tb00787.x http://dx.doi.org/10.1111/j.1365-2958.1991.tb00787.x DOI 10.1111/j.1365-2958.1991.tb00788.x http://dx.doi.org/10.1111/j.1365-2958.1991.tb00788.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EMBL X57471 http://www.ebi.ac.uk/ena/data/view/X57471 EMBL X59402 http://www.ebi.ac.uk/ena/data/view/X59402 EchoBASE EB0292 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0292 EcoGene EG10296 http://www.ecogene.org/geneInfo.php?eg_id=EG10296 EnsemblBacteria AAC73691 http://www.ensemblgenomes.org/id/AAC73691 EnsemblBacteria AAC73691 http://www.ensemblgenomes.org/id/AAC73691 EnsemblBacteria BAE76345 http://www.ensemblgenomes.org/id/BAE76345 EnsemblBacteria BAE76345 http://www.ensemblgenomes.org/id/BAE76345 EnsemblBacteria BAE76345 http://www.ensemblgenomes.org/id/BAE76345 EnsemblBacteria b0590 http://www.ensemblgenomes.org/id/b0590 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0015620 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015620 GO_process GO:0015685 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015685 GO_process GO:0055072 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055072 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 Gene3D 1.10.3470.10 http://www.cathdb.info/version/latest/superfamily/1.10.3470.10 GeneID 945214 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945214 HOGENOM HOG000045410 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000045410&db=HOGENOM6 InParanoid P23876 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23876 InterPro IPR000522 http://www.ebi.ac.uk/interpro/entry/IPR000522 InterPro IPR029022 http://www.ebi.ac.uk/interpro/entry/IPR029022 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0582 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0582 KEGG_Gene eco:b0590 http://www.genome.jp/dbget-bin/www_bget?eco:b0590 KEGG_Orthology KO:K02015 http://www.genome.jp/dbget-bin/www_bget?KO:K02015 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA HIIRILI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HIIRILI PANTHER PTHR30472 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30472 PSORT swissprot:FEPD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FEPD_ECOLI PSORT-B swissprot:FEPD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FEPD_ECOLI PSORT2 swissprot:FEPD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FEPD_ECOLI Pfam PF01032 http://pfam.xfam.org/family/PF01032 Phobius swissprot:FEPD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FEPD_ECOLI PhylomeDB P23876 http://phylomedb.org/?seqid=P23876 ProteinModelPortal P23876 http://www.proteinmodelportal.org/query/uniprot/P23876 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1787794 http://www.ncbi.nlm.nih.gov/pubmed/1787794 PubMed 1838574 http://www.ncbi.nlm.nih.gov/pubmed/1838574 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415122 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415122 RefSeq WP_000016947 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000016947 STRING 511145.b0590 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0590&targetmode=cogs STRING COG0609 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0609&targetmode=cogs SUPFAM SSF81345 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81345 TCDB 3.A.1.14 http://www.tcdb.org/search/result.php?tc=3.A.1.14 UniProtKB FEPD_ECOLI http://www.uniprot.org/uniprot/FEPD_ECOLI UniProtKB-AC P23876 http://www.uniprot.org/uniprot/P23876 charge swissprot:FEPD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FEPD_ECOLI eggNOG COG0609 http://eggnogapi.embl.de/nog_data/html/tree/COG0609 eggNOG ENOG4105DQ5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DQ5 epestfind swissprot:FEPD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FEPD_ECOLI garnier swissprot:FEPD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FEPD_ECOLI helixturnhelix swissprot:FEPD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FEPD_ECOLI hmoment swissprot:FEPD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FEPD_ECOLI iep swissprot:FEPD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FEPD_ECOLI inforesidue swissprot:FEPD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FEPD_ECOLI octanol swissprot:FEPD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FEPD_ECOLI pepcoil swissprot:FEPD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FEPD_ECOLI pepdigest swissprot:FEPD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FEPD_ECOLI pepinfo swissprot:FEPD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FEPD_ECOLI pepnet swissprot:FEPD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FEPD_ECOLI pepstats swissprot:FEPD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FEPD_ECOLI pepwheel swissprot:FEPD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FEPD_ECOLI pepwindow swissprot:FEPD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FEPD_ECOLI sigcleave swissprot:FEPD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FEPD_ECOLI ## Database ID URL or Descriptions # BioGrid 4259754 4 # CDD cd06261 TM_PBP2 # EcoGene EG11737 metI # FUNCTION METI_ECOLI Part of the binding-protein-dependent transport system for D-methionine and the toxic methionine analog alpha-methyl- methionine. Probably responsible for the translocation of the substrate across the membrane. {ECO 0000269|PubMed 12169620}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006865 amino acid transport; IEA:UniProtKB-KW. # GO_process GO:0048473 D-methionine transport; IMP:CACAO. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006810 transport # Gene3D 1.10.3720.10 -; 1. # INTERACTION METI_ECOLI P30750 metN; NbExp=2; IntAct=EBI-8769561, EBI-541886; # InterPro IPR000515 MetI-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00238 D-Methionine transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism METI_ECOLI Escherichia coli (strain K12) # PATRIC 32115509 VBIEscCol129921_0206 # PDB 3DHW X-ray; 3.70 A; A/B/E/F=1-217 # PDB 3TUI X-ray; 2.90 A; A/B/E/F=1-217 # PDB 3TUJ X-ray; 4.00 A; A/B=1-217 # PDB 3TUZ X-ray; 3.40 A; A/B/E/F=1-217 # PIR F64744 F64744 # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName METI_ECOLI D-methionine transport system permease protein MetI # RefSeq NP_414740 NC_000913.3 # RefSeq WP_001294600 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA03658.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION METI_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF161098 SSF161098 # TCDB 3.A.1.24 the atp-binding cassette (abc) superfamily # eggNOG COG2011 LUCA # eggNOG ENOG4108UMI Bacteria BLAST swissprot:METI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:METI_ECOLI BioCyc ECOL316407:JW0194-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0194-MONOMER BioCyc EcoCyc:METI-MONOMER http://biocyc.org/getid?id=EcoCyc:METI-MONOMER BioCyc MetaCyc:METI-MONOMER http://biocyc.org/getid?id=MetaCyc:METI-MONOMER COG COG2011 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2011 DIP DIP-11198N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11198N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.17.4930-4932.2002 http://dx.doi.org/10.1128/JB.184.17.4930-4932.2002 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D15061 http://www.ebi.ac.uk/ena/data/view/D15061 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EchoBASE EB1688 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1688 EcoGene EG11737 http://www.ecogene.org/geneInfo.php?eg_id=EG11737 EnsemblBacteria AAC73309 http://www.ensemblgenomes.org/id/AAC73309 EnsemblBacteria AAC73309 http://www.ensemblgenomes.org/id/AAC73309 EnsemblBacteria BAA77875 http://www.ensemblgenomes.org/id/BAA77875 EnsemblBacteria BAA77875 http://www.ensemblgenomes.org/id/BAA77875 EnsemblBacteria BAA77875 http://www.ensemblgenomes.org/id/BAA77875 EnsemblBacteria b0198 http://www.ensemblgenomes.org/id/b0198 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006865 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865 GO_process GO:0048473 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048473 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 944894 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944894 HOGENOM HOG000222815 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000222815&db=HOGENOM6 InParanoid P31547 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31547 IntAct P31547 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31547* InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0194 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0194 KEGG_Gene eco:b0198 http://www.genome.jp/dbget-bin/www_bget?eco:b0198 KEGG_Orthology KO:K02072 http://www.genome.jp/dbget-bin/www_bget?KO:K02072 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA QRYITEV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QRYITEV PDB 3DHW http://www.ebi.ac.uk/pdbe-srv/view/entry/3DHW PDB 3TUI http://www.ebi.ac.uk/pdbe-srv/view/entry/3TUI PDB 3TUJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3TUJ PDB 3TUZ http://www.ebi.ac.uk/pdbe-srv/view/entry/3TUZ PDBsum 3DHW http://www.ebi.ac.uk/pdbsum/3DHW PDBsum 3TUI http://www.ebi.ac.uk/pdbsum/3TUI PDBsum 3TUJ http://www.ebi.ac.uk/pdbsum/3TUJ PDBsum 3TUZ http://www.ebi.ac.uk/pdbsum/3TUZ PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:METI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:METI_ECOLI PSORT-B swissprot:METI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:METI_ECOLI PSORT2 swissprot:METI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:METI_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Phobius swissprot:METI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:METI_ECOLI PhylomeDB P31547 http://phylomedb.org/?seqid=P31547 ProteinModelPortal P31547 http://www.proteinmodelportal.org/query/uniprot/P31547 PubMed 12169620 http://www.ncbi.nlm.nih.gov/pubmed/12169620 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414740 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414740 RefSeq WP_001294600 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001294600 SMR P31547 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31547 STRING 511145.b0198 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0198&targetmode=cogs STRING COG2011 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2011&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.24 http://www.tcdb.org/search/result.php?tc=3.A.1.24 UniProtKB METI_ECOLI http://www.uniprot.org/uniprot/METI_ECOLI UniProtKB-AC P31547 http://www.uniprot.org/uniprot/P31547 charge swissprot:METI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:METI_ECOLI eggNOG COG2011 http://eggnogapi.embl.de/nog_data/html/tree/COG2011 eggNOG ENOG4108UMI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UMI epestfind swissprot:METI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:METI_ECOLI garnier swissprot:METI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:METI_ECOLI helixturnhelix swissprot:METI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:METI_ECOLI hmoment swissprot:METI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:METI_ECOLI iep swissprot:METI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:METI_ECOLI inforesidue swissprot:METI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:METI_ECOLI octanol swissprot:METI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:METI_ECOLI pepcoil swissprot:METI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:METI_ECOLI pepdigest swissprot:METI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:METI_ECOLI pepinfo swissprot:METI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:METI_ECOLI pepnet swissprot:METI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:METI_ECOLI pepstats swissprot:METI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:METI_ECOLI pepwheel swissprot:METI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:METI_ECOLI pepwindow swissprot:METI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:METI_ECOLI sigcleave swissprot:METI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:METI_ECOLI ## Database ID URL or Descriptions # BRENDA 2.7.13 2026 # CATALYTIC ACTIVITY BAES_ECOLI ATP + protein L-histidine = ADP + protein N- phospho-L-histidine. # CDD cd06225 HAMP # DISRUPTION PHENOTYPE Loss of induction of the CRISPR-Cas casABCDE-ygbT-ygbF operon (PubMed:21255106). {ECO 0000269|PubMed:21255106}. # EcoGene EG11617 baeS # FUNCTION BAES_ECOLI Member of the two-component regulatory system BaeS/BaeR which responds to envelope stress (PubMed 12354228, PubMed 21317898). Activates expression of periplasmic chaperone spy in response to spheroplast formation, indole and P pili protein PapG overexpression (PubMed 12354228). Activates BaeR by phosphorylation which then activates the mdtABCD (PubMed 12107134) and probably the CRISPR-Cas casABCDE-ygbT-ygbF operons (PubMed 21255106). {ECO 0000269|PubMed 12354228, ECO 0000269|PubMed 15522865, ECO 0000269|PubMed 21255106, ECO 0000269|PubMed 21317898}. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0000155 phosphorelay sensor kinase activity; IEA:InterPro. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0000160 phosphorelay signal transduction system; IMP:EcoCyc. # GO_process GO:0046777 protein autophosphorylation; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005622 intracellular # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0007165 signal transduction # Gene3D 1.10.287.130 -; 1. # Gene3D 3.30.565.10 -; 1. # IntAct P30847 3 # InterPro IPR003594 HATPase_C # InterPro IPR003660 HAMP_dom # InterPro IPR003661 HisK_dim/P # InterPro IPR004358 Sig_transdc_His_kin-like_C # InterPro IPR005467 His_kinase_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01001 Protein kinases # KEGG_Brite ko02022 M00450 BaeS-BaeR (envelope stress response) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # Organism BAES_ECOLI Escherichia coli (strain K12) # PATRIC 32119489 VBIEscCol129921_2155 # PIR E64974 E64974 # PRINTS PR00344 BCTRLSENSOR # PROSITE PS50109 HIS_KIN # PROSITE PS50885 HAMP # PTM BAES_ECOLI Autophosphorylated. {ECO 0000269|PubMed 15522865}. # Pfam PF00512 HisKA # Pfam PF00672 HAMP # Pfam PF02518 HATPase_c # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BAES_ECOLI Signal transduction histidine-protein kinase BaeS # RefSeq NP_416582 NC_000913.3 # RefSeq WP_000675150 NZ_LN832404.1 # SIMILARITY Contains 1 HAMP domain. {ECO:0000255|PROSITE- ProRule PRU00102}. # SIMILARITY Contains 1 histidine kinase domain. {ECO:0000255|PROSITE-ProRule PRU00107}. # SMART SM00304 HAMP # SMART SM00387 HATPase_c # SMART SM00388 HisKA # SUBCELLULAR LOCATION BAES_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # SUPFAM SSF47384 SSF47384 # SUPFAM SSF55874 SSF55874 # eggNOG COG0642 LUCA # eggNOG ENOG4105EB3 Bacteria BLAST swissprot:BAES_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BAES_ECOLI BioCyc ECOL316407:JW2063-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2063-MONOMER BioCyc EcoCyc:BAES-MONOMER http://biocyc.org/getid?id=EcoCyc:BAES-MONOMER COG COG0642 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0642 DIP DIP-9199N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9199N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsmb.2016 http://dx.doi.org/10.1038/nsmb.2016 DOI 10.1046/j.1365-2958.2002.03112.x http://dx.doi.org/10.1046/j.1365-2958.2002.03112.x DOI 10.1074/jbc.M410104200 http://dx.doi.org/10.1074/jbc.M410104200 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1111/j.1365-2958.2010.07482.x http://dx.doi.org/10.1111/j.1365-2958.2010.07482.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.15.4168-4176.2002 http://dx.doi.org/10.1128/JB.184.15.4168-4176.2002 EC_number EC:2.7.13.3 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.13.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D14054 http://www.ebi.ac.uk/ena/data/view/D14054 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.13.3 http://enzyme.expasy.org/EC/2.7.13.3 EchoBASE EB1574 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1574 EcoGene EG11617 http://www.ecogene.org/geneInfo.php?eg_id=EG11617 EnsemblBacteria AAC75139 http://www.ensemblgenomes.org/id/AAC75139 EnsemblBacteria AAC75139 http://www.ensemblgenomes.org/id/AAC75139 EnsemblBacteria BAA15934 http://www.ensemblgenomes.org/id/BAA15934 EnsemblBacteria BAA15934 http://www.ensemblgenomes.org/id/BAA15934 EnsemblBacteria BAA15934 http://www.ensemblgenomes.org/id/BAA15934 EnsemblBacteria b2078 http://www.ensemblgenomes.org/id/b2078 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0000155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000155 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0046777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046777 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 Gene3D 1.10.287.130 http://www.cathdb.info/version/latest/superfamily/1.10.287.130 Gene3D 3.30.565.10 http://www.cathdb.info/version/latest/superfamily/3.30.565.10 GeneID 946611 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946611 HOGENOM HOG000223179 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000223179&db=HOGENOM6 InParanoid P30847 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30847 IntAct P30847 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P30847* IntEnz 2.7.13.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.13.3 InterPro IPR003594 http://www.ebi.ac.uk/interpro/entry/IPR003594 InterPro IPR003660 http://www.ebi.ac.uk/interpro/entry/IPR003660 InterPro IPR003661 http://www.ebi.ac.uk/interpro/entry/IPR003661 InterPro IPR004358 http://www.ebi.ac.uk/interpro/entry/IPR004358 InterPro IPR005467 http://www.ebi.ac.uk/interpro/entry/IPR005467 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01001 http://www.genome.jp/dbget-bin/www_bget?ko01001 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW2063 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2063 KEGG_Gene eco:b2078 http://www.genome.jp/dbget-bin/www_bget?eco:b2078 KEGG_Orthology KO:K07642 http://www.genome.jp/dbget-bin/www_bget?KO:K07642 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA SNEQRIN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SNEQRIN PRINTS PR00344 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00344 PROSITE PS50109 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50109 PROSITE PS50885 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50885 PSORT swissprot:BAES_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BAES_ECOLI PSORT-B swissprot:BAES_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BAES_ECOLI PSORT2 swissprot:BAES_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BAES_ECOLI Pfam PF00512 http://pfam.xfam.org/family/PF00512 Pfam PF00672 http://pfam.xfam.org/family/PF00672 Pfam PF02518 http://pfam.xfam.org/family/PF02518 Phobius swissprot:BAES_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BAES_ECOLI PhylomeDB P30847 http://phylomedb.org/?seqid=P30847 ProteinModelPortal P30847 http://www.proteinmodelportal.org/query/uniprot/P30847 PubMed 12107134 http://www.ncbi.nlm.nih.gov/pubmed/12107134 PubMed 12354228 http://www.ncbi.nlm.nih.gov/pubmed/12354228 PubMed 15522865 http://www.ncbi.nlm.nih.gov/pubmed/15522865 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21255106 http://www.ncbi.nlm.nih.gov/pubmed/21255106 PubMed 21317898 http://www.ncbi.nlm.nih.gov/pubmed/21317898 PubMed 8282725 http://www.ncbi.nlm.nih.gov/pubmed/8282725 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416582 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416582 RefSeq WP_000675150 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000675150 SMART SM00304 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00304 SMART SM00387 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00387 SMART SM00388 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00388 SMR P30847 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P30847 STRING 511145.b2078 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2078&targetmode=cogs STRING COG0642 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0642&targetmode=cogs SUPFAM SSF47384 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47384 SUPFAM SSF55874 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55874 UniProtKB BAES_ECOLI http://www.uniprot.org/uniprot/BAES_ECOLI UniProtKB-AC P30847 http://www.uniprot.org/uniprot/P30847 charge swissprot:BAES_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BAES_ECOLI eggNOG COG0642 http://eggnogapi.embl.de/nog_data/html/tree/COG0642 eggNOG ENOG4105EB3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EB3 epestfind swissprot:BAES_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BAES_ECOLI garnier swissprot:BAES_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BAES_ECOLI helixturnhelix swissprot:BAES_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BAES_ECOLI hmoment swissprot:BAES_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BAES_ECOLI iep swissprot:BAES_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BAES_ECOLI inforesidue swissprot:BAES_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BAES_ECOLI octanol swissprot:BAES_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BAES_ECOLI pepcoil swissprot:BAES_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BAES_ECOLI pepdigest swissprot:BAES_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BAES_ECOLI pepinfo swissprot:BAES_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BAES_ECOLI pepnet swissprot:BAES_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BAES_ECOLI pepstats swissprot:BAES_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BAES_ECOLI pepwheel swissprot:BAES_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BAES_ECOLI pepwindow swissprot:BAES_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BAES_ECOLI sigcleave swissprot:BAES_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BAES_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES DAPA_ECOLI Kinetic parameters KM=0.26 mM for pyruvate {ECO 0000269|PubMed 14580236, ECO 0000269|PubMed 15066435}; KM=0.11 mM for L-aspartate-4-semialdehyde {ECO 0000269|PubMed 14580236, ECO 0000269|PubMed 15066435}; Vmax=0.58 umol/sec/mg enzyme {ECO 0000269|PubMed 14580236, ECO 0000269|PubMed 15066435}; Note=kcat is 124 sec(-1).; # BRENDA 4.3.3 2026 # CATALYTIC ACTIVITY DAPA_ECOLI Pyruvate + L-aspartate-4-semialdehyde = (4S)- 4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinate + H(2)O. {ECO 0000255|HAMAP-Rule MF_00418, ECO 0000269|PubMed 20503968, ECO 0000269|PubMed 8993314}. # CAUTION DAPA_ECOLI Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate- beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy- 2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB (PubMed 8993314, PubMed 20503968). {ECO 0000305|PubMed 20503968, ECO 0000305|PubMed 8993314}. # CDD cd00950 DHDPS # ENZYME REGULATION DAPA_ECOLI Is allosterically regulated by the feedback inhibitor (S)-lysine. Is inhibited by pyruvate analogs such as 3- fluoropyruvate, 2-ketobutyrate, glyoxylate, and beta- hydroxypyruvate. Is not inhibited by its substrate, (S)-ASA. {ECO 0000269|PubMed 14580236, ECO 0000269|PubMed 18787203, ECO 0000269|PubMed 9048556}. # EcoGene EG10205 dapA # FUNCTION DAPA_ECOLI Catalyzes the condensation of (S)-aspartate-beta- semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA). {ECO 0000255|HAMAP-Rule MF_00418, ECO 0000269|PubMed 20503968, ECO 0000269|PubMed 8993314}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0008840 4-hydroxy-tetrahydrodipicolinate synthase; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0009089 lysine biosynthetic process via diaminopimelate; IEA:UniProtKB-UniPathway. # GO_process GO:0019877 diaminopimelate biosynthetic process; IDA:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.20.20.70 -; 1. # HAMAP MF_00418 DapA # INTERACTION DAPA_ECOLI Self; NbExp=2; IntAct=EBI-907527, EBI-907527; # IntAct P0A6L2 3 # InterPro IPR002220 DapA-like # InterPro IPR005263 DapA # InterPro IPR013785 Aldolase_TIM # InterPro IPR020624 Schiff_base-form_aldolases_CS # InterPro IPR020625 Schiff_base-form_aldolases_AS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00300 Lysine biosynthesis # MASS SPECTROMETRY Mass=31270; Method=Electrospray; Range=1-292; Evidence={ECO:0000269|PubMed 18787203}; # MASS SPECTROMETRY Mass=31272; Mass_error=1; Method=Electrospray; Range=1-292; Evidence={ECO:0000269|PubMed 14580236}; # Organism DAPA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR12128 PTHR12128 # PATHWAY Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4. {ECO 0000255|HAMAP-Rule:MF_00418}. # PATRIC 32120343 VBIEscCol129921_2574 # PDB 1DHP X-ray; 2.30 A; A/B=1-292 # PDB 1S5T X-ray; 2.30 A; A/B=1-292 # PDB 1S5V X-ray; 2.35 A; A/B=1-292 # PDB 1S5W X-ray; 2.32 A; A/B=1-292 # PDB 1YXC X-ray; 1.90 A; A/B=1-292 # PDB 1YXD X-ray; 2.00 A; A/B=1-292 # PDB 2A6L X-ray; 2.05 A; A/B=1-292 # PDB 2A6N X-ray; 1.94 A; A/B=1-292 # PDB 2ATS X-ray; 1.90 A; A/B=1-292 # PDB 2OJP X-ray; 1.70 A; A/B=1-292 # PDB 2PUR X-ray; 1.70 A; A/B=1-292 # PDB 3C0J X-ray; 2.40 A; A/B=1-292 # PDB 3DEN X-ray; 2.20 A; A/B=1-292 # PDB 3DU0 X-ray; 2.00 A; A/B=1-292 # PDB 3I7Q X-ray; 2.00 A; A/B=1-292 # PDB 3I7R X-ray; 2.10 A; A/B=1-292 # PDB 3I7S X-ray; 2.30 A; A/B=1-292 # PDB 4EOU X-ray; 2.30 A; A/B=1-292 # PDB 5T26 X-ray; 2.10 A; A/B=1-292 # PIR E65023 SYECDP # PIRSF PIRSF001365 DHDPS # PRINTS PR00146 DHPICSNTHASE # PROSITE PS00665 DHDPS_1 # PROSITE PS00666 DHDPS_2 # Pfam PF00701 DHDPS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 4-hydroxy-tetrahydrodipicolinate synthase {ECO:0000255|HAMAP-Rule MF_00418} # RefSeq NP_416973 NC_000913.3 # RefSeq WP_001311023 NZ_LN832404.1 # SIMILARITY Belongs to the DapA family. {ECO:0000255|HAMAP- Rule MF_00418}. # SMART SM01130 DHDPS # SUBCELLULAR LOCATION DAPA_ECOLI Cytoplasm. # SUBUNIT DAPA_ECOLI Homotetramer; dimer of dimers. {ECO 0000255|HAMAP- Rule MF_00418, ECO 0000269|PubMed 16041077, ECO 0000269|PubMed 18556019, ECO 0000269|PubMed 18937497, ECO 0000269|PubMed 20353808, ECO 0000269|PubMed 22552955, ECO 0000269|Ref.22}. # TIGRFAMs TIGR00674 dapA # UniPathway UPA00034 UER00017 # eggNOG COG0329 LUCA # eggNOG ENOG4105CDP Bacteria BLAST swissprot:DAPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DAPA_ECOLI BioCyc ECOL316407:JW2463-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2463-MONOMER BioCyc EcoCyc:DIHYDRODIPICSYN-MONOMER http://biocyc.org/getid?id=EcoCyc:DIHYDRODIPICSYN-MONOMER BioCyc MetaCyc:DIHYDRODIPICSYN-MONOMER http://biocyc.org/getid?id=MetaCyc:DIHYDRODIPICSYN-MONOMER COG COG0329 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0329 DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1002/prot.24106 http://dx.doi.org/10.1002/prot.24106 DOI 10.1006/jmbi.1994.0078 http://dx.doi.org/10.1006/jmbi.1994.0078 DOI 10.1006/jmbi.1998.1726 http://dx.doi.org/10.1006/jmbi.1998.1726 DOI 10.1016/j.biochi.2009.05.013 http://dx.doi.org/10.1016/j.biochi.2009.05.013 DOI 10.1016/j.biochi.2010.03.004 http://dx.doi.org/10.1016/j.biochi.2010.03.004 DOI 10.1016/j.bmc.2008.10.026 http://dx.doi.org/10.1016/j.bmc.2008.10.026 DOI 10.1016/j.bmc.2012.01.045 http://dx.doi.org/10.1016/j.bmc.2012.01.045 DOI 10.1016/j.jmb.2004.02.060 http://dx.doi.org/10.1016/j.jmb.2004.02.060 DOI 10.1016/j.jmb.2008.05.038 http://dx.doi.org/10.1016/j.jmb.2008.05.038 DOI 10.1021/bi051281w http://dx.doi.org/10.1021/bi051281w DOI 10.1021/bi801094t http://dx.doi.org/10.1021/bi801094t DOI 10.1021/bi962264x http://dx.doi.org/10.1021/bi962264x DOI 10.1021/bi962272d http://dx.doi.org/10.1021/bi962272d DOI 10.1021/jm100349s http://dx.doi.org/10.1021/jm100349s DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/BJ20031389 http://dx.doi.org/10.1042/BJ20031389 DOI 10.1042/bj2880691 http://dx.doi.org/10.1042/bj2880691 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1107/S0907444905016318 http://dx.doi.org/10.1107/S0907444905016318 DOI 10.1107/S1744309108033654 http://dx.doi.org/10.1107/S1744309108033654 DOI 10.1110/ps.037440.108 http://dx.doi.org/10.1110/ps.037440.108 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.3.3.7 {ECO:0000255|HAMAP-Rule:MF_00418} http://www.genome.jp/dbget-bin/www_bget?EC:4.3.3.7 {ECO:0000255|HAMAP-Rule:MF_00418} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M12844 http://www.ebi.ac.uk/ena/data/view/M12844 EMBL M33928 http://www.ebi.ac.uk/ena/data/view/M33928 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X57402 http://www.ebi.ac.uk/ena/data/view/X57402 ENZYME 4.3.3.7 {ECO:0000255|HAMAP-Rule:MF_00418} http://enzyme.expasy.org/EC/4.3.3.7 {ECO:0000255|HAMAP-Rule:MF_00418} EchoBASE EB0201 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0201 EcoGene EG10205 http://www.ecogene.org/geneInfo.php?eg_id=EG10205 EnsemblBacteria AAC75531 http://www.ensemblgenomes.org/id/AAC75531 EnsemblBacteria AAC75531 http://www.ensemblgenomes.org/id/AAC75531 EnsemblBacteria BAA16355 http://www.ensemblgenomes.org/id/BAA16355 EnsemblBacteria BAA16355 http://www.ensemblgenomes.org/id/BAA16355 EnsemblBacteria BAA16355 http://www.ensemblgenomes.org/id/BAA16355 EnsemblBacteria b2478 http://www.ensemblgenomes.org/id/b2478 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008840 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008840 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0009089 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009089 GO_process GO:0019877 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019877 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 946952 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946952 HAMAP MF_00418 http://hamap.expasy.org/unirule/MF_00418 HOGENOM HOG000173604 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000173604&db=HOGENOM6 InParanoid P0A6L2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6L2 IntAct P0A6L2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6L2* IntEnz 4.3.3.7 {ECO:0000255|HAMAP-Rule:MF_00418} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.3.3.7 {ECO:0000255|HAMAP-Rule:MF_00418} InterPro IPR002220 http://www.ebi.ac.uk/interpro/entry/IPR002220 InterPro IPR005263 http://www.ebi.ac.uk/interpro/entry/IPR005263 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR020624 http://www.ebi.ac.uk/interpro/entry/IPR020624 InterPro IPR020625 http://www.ebi.ac.uk/interpro/entry/IPR020625 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2463 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2463 KEGG_Gene eco:b2478 http://www.genome.jp/dbget-bin/www_bget?eco:b2478 KEGG_Orthology KO:K01714 http://www.genome.jp/dbget-bin/www_bget?KO:K01714 KEGG_Pathway ko00300 http://www.genome.jp/kegg-bin/show_pathway?ko00300 KEGG_Reaction rn:R10147 http://www.genome.jp/dbget-bin/www_bget?rn:R10147 OMA GMDACVP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GMDACVP PANTHER PTHR12128 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12128 PDB 1DHP http://www.ebi.ac.uk/pdbe-srv/view/entry/1DHP PDB 1S5T http://www.ebi.ac.uk/pdbe-srv/view/entry/1S5T PDB 1S5V http://www.ebi.ac.uk/pdbe-srv/view/entry/1S5V PDB 1S5W http://www.ebi.ac.uk/pdbe-srv/view/entry/1S5W PDB 1YXC http://www.ebi.ac.uk/pdbe-srv/view/entry/1YXC PDB 1YXD http://www.ebi.ac.uk/pdbe-srv/view/entry/1YXD PDB 2A6L http://www.ebi.ac.uk/pdbe-srv/view/entry/2A6L PDB 2A6N http://www.ebi.ac.uk/pdbe-srv/view/entry/2A6N PDB 2ATS http://www.ebi.ac.uk/pdbe-srv/view/entry/2ATS PDB 2OJP http://www.ebi.ac.uk/pdbe-srv/view/entry/2OJP PDB 2PUR http://www.ebi.ac.uk/pdbe-srv/view/entry/2PUR PDB 3C0J http://www.ebi.ac.uk/pdbe-srv/view/entry/3C0J PDB 3DEN http://www.ebi.ac.uk/pdbe-srv/view/entry/3DEN PDB 3DU0 http://www.ebi.ac.uk/pdbe-srv/view/entry/3DU0 PDB 3I7Q http://www.ebi.ac.uk/pdbe-srv/view/entry/3I7Q PDB 3I7R http://www.ebi.ac.uk/pdbe-srv/view/entry/3I7R PDB 3I7S http://www.ebi.ac.uk/pdbe-srv/view/entry/3I7S PDB 4EOU http://www.ebi.ac.uk/pdbe-srv/view/entry/4EOU PDB 5T26 http://www.ebi.ac.uk/pdbe-srv/view/entry/5T26 PDBsum 1DHP http://www.ebi.ac.uk/pdbsum/1DHP PDBsum 1S5T http://www.ebi.ac.uk/pdbsum/1S5T PDBsum 1S5V http://www.ebi.ac.uk/pdbsum/1S5V PDBsum 1S5W http://www.ebi.ac.uk/pdbsum/1S5W PDBsum 1YXC http://www.ebi.ac.uk/pdbsum/1YXC PDBsum 1YXD http://www.ebi.ac.uk/pdbsum/1YXD PDBsum 2A6L http://www.ebi.ac.uk/pdbsum/2A6L PDBsum 2A6N http://www.ebi.ac.uk/pdbsum/2A6N PDBsum 2ATS http://www.ebi.ac.uk/pdbsum/2ATS PDBsum 2OJP http://www.ebi.ac.uk/pdbsum/2OJP PDBsum 2PUR http://www.ebi.ac.uk/pdbsum/2PUR PDBsum 3C0J http://www.ebi.ac.uk/pdbsum/3C0J PDBsum 3DEN http://www.ebi.ac.uk/pdbsum/3DEN PDBsum 3DU0 http://www.ebi.ac.uk/pdbsum/3DU0 PDBsum 3I7Q http://www.ebi.ac.uk/pdbsum/3I7Q PDBsum 3I7R http://www.ebi.ac.uk/pdbsum/3I7R PDBsum 3I7S http://www.ebi.ac.uk/pdbsum/3I7S PDBsum 4EOU http://www.ebi.ac.uk/pdbsum/4EOU PDBsum 5T26 http://www.ebi.ac.uk/pdbsum/5T26 PRINTS PR00146 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00146 PROSITE PS00665 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00665 PROSITE PS00666 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00666 PSORT swissprot:DAPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DAPA_ECOLI PSORT-B swissprot:DAPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DAPA_ECOLI PSORT2 swissprot:DAPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DAPA_ECOLI Pfam PF00701 http://pfam.xfam.org/family/PF00701 Phobius swissprot:DAPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DAPA_ECOLI PhylomeDB P0A6L2 http://phylomedb.org/?seqid=P0A6L2 ProteinModelPortal P0A6L2 http://www.proteinmodelportal.org/query/uniprot/P0A6L2 PubMed 14580236 http://www.ncbi.nlm.nih.gov/pubmed/14580236 PubMed 1463470 http://www.ncbi.nlm.nih.gov/pubmed/1463470 PubMed 15066435 http://www.ncbi.nlm.nih.gov/pubmed/15066435 PubMed 16041077 http://www.ncbi.nlm.nih.gov/pubmed/16041077 PubMed 16185069 http://www.ncbi.nlm.nih.gov/pubmed/16185069 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18556019 http://www.ncbi.nlm.nih.gov/pubmed/18556019 PubMed 18787203 http://www.ncbi.nlm.nih.gov/pubmed/18787203 PubMed 1885529 http://www.ncbi.nlm.nih.gov/pubmed/1885529 PubMed 18937497 http://www.ncbi.nlm.nih.gov/pubmed/18937497 PubMed 18977662 http://www.ncbi.nlm.nih.gov/pubmed/18977662 PubMed 19052357 http://www.ncbi.nlm.nih.gov/pubmed/19052357 PubMed 19505526 http://www.ncbi.nlm.nih.gov/pubmed/19505526 PubMed 20353808 http://www.ncbi.nlm.nih.gov/pubmed/20353808 PubMed 20503968 http://www.ncbi.nlm.nih.gov/pubmed/20503968 PubMed 2120198 http://www.ncbi.nlm.nih.gov/pubmed/2120198 PubMed 22386717 http://www.ncbi.nlm.nih.gov/pubmed/22386717 PubMed 22552955 http://www.ncbi.nlm.nih.gov/pubmed/22552955 PubMed 3514578 http://www.ncbi.nlm.nih.gov/pubmed/3514578 PubMed 7853400 http://www.ncbi.nlm.nih.gov/pubmed/7853400 PubMed 8993314 http://www.ncbi.nlm.nih.gov/pubmed/8993314 PubMed 9048556 http://www.ncbi.nlm.nih.gov/pubmed/9048556 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 RefSeq NP_416973 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416973 RefSeq WP_001311023 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001311023 SMART SM01130 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01130 SMR P0A6L2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6L2 STRING 511145.b2478 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2478&targetmode=cogs STRING COG0329 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0329&targetmode=cogs SWISS-2DPAGE P0A6L2 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A6L2 TIGRFAMs TIGR00674 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00674 UniProtKB DAPA_ECOLI http://www.uniprot.org/uniprot/DAPA_ECOLI UniProtKB-AC P0A6L2 http://www.uniprot.org/uniprot/P0A6L2 charge swissprot:DAPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DAPA_ECOLI eggNOG COG0329 http://eggnogapi.embl.de/nog_data/html/tree/COG0329 eggNOG ENOG4105CDP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CDP epestfind swissprot:DAPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DAPA_ECOLI garnier swissprot:DAPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DAPA_ECOLI helixturnhelix swissprot:DAPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DAPA_ECOLI hmoment swissprot:DAPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DAPA_ECOLI iep swissprot:DAPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DAPA_ECOLI inforesidue swissprot:DAPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DAPA_ECOLI octanol swissprot:DAPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DAPA_ECOLI pepcoil swissprot:DAPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DAPA_ECOLI pepdigest swissprot:DAPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DAPA_ECOLI pepinfo swissprot:DAPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DAPA_ECOLI pepnet swissprot:DAPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DAPA_ECOLI pepstats swissprot:DAPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DAPA_ECOLI pepwheel swissprot:DAPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DAPA_ECOLI pepwindow swissprot:DAPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DAPA_ECOLI sigcleave swissprot:DAPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DAPA_ECOLI ## Database ID URL or Descriptions # AltName LPL_ECOLI Leu operon attenuator peptide # EcoGene EG11280 leuL # FUNCTION LPL_ECOLI Involved in control of the biosynthesis of leucine. # GO_process GO:0009082 branched-chain amino acid biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0009098 leucine biosynthetic process; IEA:UniProtKB-KW. # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # InterPro IPR012570 Leu_leader # Organism LPL_ECOLI Escherichia coli (strain K12) # PIR A30376 LFECL # Pfam PF08054 Leu_leader # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LPL_ECOLI Leu operon leader peptide # RefSeq NP_414617 NC_000913.3 # RefSeq WP_001300467 NZ_LN832404.1 BLAST swissprot:LPL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LPL_ECOLI BioCyc ECOL316407:JW0074-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0074-MONOMER BioCyc EcoCyc:EG11280-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11280-MONOMER DOI 10.1016/0022-2836(81)90348-X http://dx.doi.org/10.1016/0022-2836(81)90348-X DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01642 http://www.ebi.ac.uk/ena/data/view/J01642 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X55034 http://www.ebi.ac.uk/ena/data/view/X55034 EchoBASE EB1257 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1257 EcoGene EG11280 http://www.ecogene.org/geneInfo.php?eg_id=EG11280 EnsemblBacteria AAC73186 http://www.ensemblgenomes.org/id/AAC73186 EnsemblBacteria AAC73186 http://www.ensemblgenomes.org/id/AAC73186 EnsemblBacteria BAB96644 http://www.ensemblgenomes.org/id/BAB96644 EnsemblBacteria BAB96644 http://www.ensemblgenomes.org/id/BAB96644 EnsemblBacteria BAB96644 http://www.ensemblgenomes.org/id/BAB96644 EnsemblBacteria b0075 http://www.ensemblgenomes.org/id/b0075 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0009082 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009082 GO_process GO:0009098 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009098 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 946072 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946072 InterPro IPR012570 http://www.ebi.ac.uk/interpro/entry/IPR012570 KEGG_Gene ecj:JW0074 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0074 KEGG_Gene eco:b0075 http://www.genome.jp/dbget-bin/www_bget?eco:b0075 KEGG_Orthology KO:K05806 http://www.genome.jp/dbget-bin/www_bget?KO:K05806 PSORT swissprot:LPL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LPL_ECOLI PSORT-B swissprot:LPL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LPL_ECOLI PSORT2 swissprot:LPL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LPL_ECOLI Pfam PF08054 http://pfam.xfam.org/family/PF08054 Phobius swissprot:LPL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LPL_ECOLI PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6171647 http://www.ncbi.nlm.nih.gov/pubmed/6171647 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414617 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414617 RefSeq WP_001300467 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300467 STRING 511145.b0075 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0075&targetmode=cogs UniProtKB LPL_ECOLI http://www.uniprot.org/uniprot/LPL_ECOLI UniProtKB-AC P0AD79 http://www.uniprot.org/uniprot/P0AD79 charge swissprot:LPL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LPL_ECOLI epestfind swissprot:LPL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LPL_ECOLI garnier swissprot:LPL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LPL_ECOLI helixturnhelix swissprot:LPL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LPL_ECOLI hmoment swissprot:LPL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LPL_ECOLI iep swissprot:LPL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LPL_ECOLI inforesidue swissprot:LPL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LPL_ECOLI octanol swissprot:LPL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LPL_ECOLI pepcoil swissprot:LPL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LPL_ECOLI pepdigest swissprot:LPL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LPL_ECOLI pepinfo swissprot:LPL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LPL_ECOLI pepnet swissprot:LPL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LPL_ECOLI pepstats swissprot:LPL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LPL_ECOLI pepwheel swissprot:LPL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LPL_ECOLI pepwindow swissprot:LPL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LPL_ECOLI sigcleave swissprot:LPL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LPL_ECOLI ## Database ID URL or Descriptions # BioGrid 4262865 8 # EcoGene EG14337 ymfS # InterPro IPR003458 Phage_T4_Gp38_tail_assem # Organism YMFS_ECOLI Escherichia coli (strain K12) # PATRIC 32117547 VBIEscCol129921_1196 # PIR H64860 H64860 # PIR S07957 S07957 # Pfam PF02413 Caudo_TAP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YMFS_ECOLI Uncharacterized protein YmfS # RefSeq NP_415673 NC_000913.3 # RefSeq WP_010723096 NZ_CP010440.1 # SEQUENCE CAUTION Sequence=CAA25947.1; Type=Frameshift; Positions=18, 131; Evidence={ECO 0000305}; # SIMILARITY To E.coli YfdK. {ECO 0000305}. BLAST swissprot:YMFS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YMFS_ECOLI BioCyc ECOL316407:JW5171-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5171-MONOMER BioCyc EcoCyc:G6598-MONOMER http://biocyc.org/getid?id=EcoCyc:G6598-MONOMER DIP DIP-12729N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12729N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X01805 http://www.ebi.ac.uk/ena/data/view/X01805 EchoBASE EB4083 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4083 EcoGene EG14337 http://www.ecogene.org/geneInfo.php?eg_id=EG14337 EnsemblBacteria AAC74239 http://www.ensemblgenomes.org/id/AAC74239 EnsemblBacteria AAC74239 http://www.ensemblgenomes.org/id/AAC74239 EnsemblBacteria BAE76381 http://www.ensemblgenomes.org/id/BAE76381 EnsemblBacteria BAE76381 http://www.ensemblgenomes.org/id/BAE76381 EnsemblBacteria BAE76381 http://www.ensemblgenomes.org/id/BAE76381 EnsemblBacteria b1155 http://www.ensemblgenomes.org/id/b1155 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945724 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945724 HOGENOM HOG000118672 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118672&db=HOGENOM6 InterPro IPR003458 http://www.ebi.ac.uk/interpro/entry/IPR003458 KEGG_Gene ecj:JW5171 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5171 KEGG_Gene eco:b1155 http://www.genome.jp/dbget-bin/www_bget?eco:b1155 OMA EVIRTHD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EVIRTHD PSORT swissprot:YMFS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YMFS_ECOLI PSORT-B swissprot:YMFS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YMFS_ECOLI PSORT2 swissprot:YMFS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YMFS_ECOLI Pfam PF02413 http://pfam.xfam.org/family/PF02413 Phobius swissprot:YMFS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YMFS_ECOLI ProteinModelPortal P09154 http://www.proteinmodelportal.org/query/uniprot/P09154 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3894006 http://www.ncbi.nlm.nih.gov/pubmed/3894006 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415673 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415673 RefSeq WP_010723096 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_010723096 STRING 511145.b1155 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1155&targetmode=cogs UniProtKB YMFS_ECOLI http://www.uniprot.org/uniprot/YMFS_ECOLI UniProtKB-AC P09154 http://www.uniprot.org/uniprot/P09154 charge swissprot:YMFS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YMFS_ECOLI epestfind swissprot:YMFS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YMFS_ECOLI garnier swissprot:YMFS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YMFS_ECOLI helixturnhelix swissprot:YMFS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YMFS_ECOLI hmoment swissprot:YMFS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YMFS_ECOLI iep swissprot:YMFS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YMFS_ECOLI inforesidue swissprot:YMFS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YMFS_ECOLI octanol swissprot:YMFS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YMFS_ECOLI pepcoil swissprot:YMFS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YMFS_ECOLI pepdigest swissprot:YMFS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YMFS_ECOLI pepinfo swissprot:YMFS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YMFS_ECOLI pepnet swissprot:YMFS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YMFS_ECOLI pepstats swissprot:YMFS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YMFS_ECOLI pepwheel swissprot:YMFS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YMFS_ECOLI pepwindow swissprot:YMFS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YMFS_ECOLI sigcleave swissprot:YMFS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YMFS_ECOLI ## Database ID URL or Descriptions # BioGrid 4263172 18 # CDD cd06174 MFS # EcoGene EG10060 araJ # FUNCTION ARAJ_ECOLI May be involved in either the transport or processing of arabinose polymers. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0055085 transmembrane transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0055085 transmembrane transport # INDUCTION ARAJ_ECOLI By arabinose. # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # KEGG_Brite ko02000 Transporters # Organism ARAJ_ECOLI Escherichia coli (strain K12) # PATRIC 32115935 VBIEscCol129921_0409 # PIR B43750 B43750 # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ARAJ_ECOLI Protein AraJ # RefSeq NP_414930 NC_000913.3 # RefSeq WP_001326926 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18120.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the major facilitator superfamily. {ECO 0000305}. # SUBCELLULAR LOCATION ARAJ_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.2.14 the major facilitator superfamily (mfs) # eggNOG COG2814 LUCA # eggNOG ENOG4105F27 Bacteria BLAST swissprot:ARAJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARAJ_ECOLI BioCyc ECOL316407:JW0386-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0386-MONOMER BioCyc EcoCyc:ARAJ-MONOMER http://biocyc.org/getid?id=EcoCyc:ARAJ-MONOMER COG COG2814 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2814 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M64787 http://www.ebi.ac.uk/ena/data/view/M64787 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB0058 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0058 EcoGene EG10060 http://www.ecogene.org/geneInfo.php?eg_id=EG10060 EnsemblBacteria AAC73499 http://www.ensemblgenomes.org/id/AAC73499 EnsemblBacteria AAC73499 http://www.ensemblgenomes.org/id/AAC73499 EnsemblBacteria BAE76176 http://www.ensemblgenomes.org/id/BAE76176 EnsemblBacteria BAE76176 http://www.ensemblgenomes.org/id/BAE76176 EnsemblBacteria BAE76176 http://www.ensemblgenomes.org/id/BAE76176 EnsemblBacteria b0396 http://www.ensemblgenomes.org/id/b0396 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 949077 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949077 HOGENOM HOG000136927 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000136927&db=HOGENOM6 InParanoid P23910 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23910 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0386 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0386 KEGG_Gene eco:b0396 http://www.genome.jp/dbget-bin/www_bget?eco:b0396 KEGG_Orthology KO:K08156 http://www.genome.jp/dbget-bin/www_bget?KO:K08156 OMA MCISNSL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MCISNSL PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:ARAJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARAJ_ECOLI PSORT-B swissprot:ARAJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARAJ_ECOLI PSORT2 swissprot:ARAJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARAJ_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:ARAJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARAJ_ECOLI PhylomeDB P23910 http://phylomedb.org/?seqid=P23910 ProteinModelPortal P23910 http://www.proteinmodelportal.org/query/uniprot/P23910 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1744033 http://www.ncbi.nlm.nih.gov/pubmed/1744033 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414930 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414930 RefSeq WP_001326926 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001326926 STRING 511145.b0396 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0396&targetmode=cogs STRING COG2814 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2814&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.2.14 http://www.tcdb.org/search/result.php?tc=2.A.1.2.14 UniProtKB ARAJ_ECOLI http://www.uniprot.org/uniprot/ARAJ_ECOLI UniProtKB-AC P23910 http://www.uniprot.org/uniprot/P23910 charge swissprot:ARAJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARAJ_ECOLI eggNOG COG2814 http://eggnogapi.embl.de/nog_data/html/tree/COG2814 eggNOG ENOG4105F27 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F27 epestfind swissprot:ARAJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARAJ_ECOLI garnier swissprot:ARAJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARAJ_ECOLI helixturnhelix swissprot:ARAJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARAJ_ECOLI hmoment swissprot:ARAJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARAJ_ECOLI iep swissprot:ARAJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARAJ_ECOLI inforesidue swissprot:ARAJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARAJ_ECOLI octanol swissprot:ARAJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARAJ_ECOLI pepcoil swissprot:ARAJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARAJ_ECOLI pepdigest swissprot:ARAJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARAJ_ECOLI pepinfo swissprot:ARAJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARAJ_ECOLI pepnet swissprot:ARAJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARAJ_ECOLI pepstats swissprot:ARAJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARAJ_ECOLI pepwheel swissprot:ARAJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARAJ_ECOLI pepwindow swissprot:ARAJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARAJ_ECOLI sigcleave swissprot:ARAJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARAJ_ECOLI ## Database ID URL or Descriptions # AltName 6-O-methylguanine-DNA methyltransferase {ECO:0000255|HAMAP-Rule MF_00772} # AltName O-6-methylguanine-DNA-alkyltransferase {ECO:0000255|HAMAP-Rule MF_00772} # BioGrid 4262876 110 # CATALYTIC ACTIVITY DNA (containing 6-O-methylguanine) + protein L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L- cysteine. {ECO:0000255|HAMAP-Rule MF_00772}. # CDD cd06445 ATase # EcoGene EG10668 ogt # FUNCTION OGT_ECOLI Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated. Can also repair O-4-methylthymine. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003684 damaged DNA binding; IBA:GO_Central. # GO_function GO:0003908 methylated-DNA-[protein]-cysteine S-methyltransferase activity; IDA:EcoCyc. # GO_process GO:0006281 DNA repair; IDA:EcoCyc. # GO_process GO:0006307 DNA dealkylation involved in DNA repair; IBA:GO_Central. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # Gene3D 1.10.10.10 -; 1. # HAMAP MF_00772 OGT # IntAct P0AFH0 6 # InterPro IPR001497 MethylDNA_cys_MeTrfase_AS # InterPro IPR008332 MethylG_MeTrfase_N # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR014048 MethylDNA_cys_MeTrfase_DNA-bd # InterPro IPR023546 MGMT # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # MISCELLANEOUS OGT_ECOLI This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles. # Organism OGT_ECOLI Escherichia coli (strain K12) # PATRIC 32117946 VBIEscCol129921_1393 # PIR B64883 XUECAD # PROSITE PS00374 MGMT # Pfam PF01035 DNA_binding_1 # Pfam PF02870 Methyltransf_1N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Methylated-DNA--protein-cysteine methyltransferase {ECO:0000255|HAMAP-Rule MF_00772} # RefSeq NP_415851 NC_000913.3 # RefSeq WP_000945011 NZ_LN832404.1 # SIMILARITY Belongs to the MGMT family. {ECO:0000255|HAMAP- Rule MF_00772}. # SUBCELLULAR LOCATION OGT_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00772}. # SUPFAM SSF46767 SSF46767 # SUPFAM SSF53155 SSF53155 # TIGRFAMs TIGR00589 ogt # eggNOG COG0350 LUCA # eggNOG ENOG4105K85 Bacteria BLAST swissprot:OGT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:OGT_ECOLI BioCyc ECOL316407:JW1329-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1329-MONOMER BioCyc EcoCyc:EG10668-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10668-MONOMER BioCyc MetaCyc:EG10668-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10668-MONOMER COG COG0350 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0350 DIP DIP-48073N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48073N DOI 10.1016/S0006-291X(05)81510-4 http://dx.doi.org/10.1016/S0006-291X(05)81510-4 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/15.22.9177 http://dx.doi.org/10.1093/nar/15.22.9177 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.1.63 {ECO:0000255|HAMAP-Rule:MF_00772} http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.63 {ECO:0000255|HAMAP-Rule:MF_00772} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL Y00495 http://www.ebi.ac.uk/ena/data/view/Y00495 ENZYME 2.1.1.63 {ECO:0000255|HAMAP-Rule:MF_00772} http://enzyme.expasy.org/EC/2.1.1.63 {ECO:0000255|HAMAP-Rule:MF_00772} EchoBASE EB0662 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0662 EcoGene EG10668 http://www.ecogene.org/geneInfo.php?eg_id=EG10668 EnsemblBacteria AAC74417 http://www.ensemblgenomes.org/id/AAC74417 EnsemblBacteria AAC74417 http://www.ensemblgenomes.org/id/AAC74417 EnsemblBacteria BAA14928 http://www.ensemblgenomes.org/id/BAA14928 EnsemblBacteria BAA14928 http://www.ensemblgenomes.org/id/BAA14928 EnsemblBacteria BAA14928 http://www.ensemblgenomes.org/id/BAA14928 EnsemblBacteria b1335 http://www.ensemblgenomes.org/id/b1335 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003684 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003684 GO_function GO:0003908 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003908 GO_process GO:0006281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006281 GO_process GO:0006307 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006307 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 945853 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945853 HAMAP MF_00772 http://hamap.expasy.org/unirule/MF_00772 HOGENOM HOG000244137 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000244137&db=HOGENOM6 InParanoid P0AFH0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFH0 IntAct P0AFH0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFH0* IntEnz 2.1.1.63 {ECO:0000255|HAMAP-Rule:MF_00772} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.63 {ECO:0000255|HAMAP-Rule:MF_00772} InterPro IPR001497 http://www.ebi.ac.uk/interpro/entry/IPR001497 InterPro IPR008332 http://www.ebi.ac.uk/interpro/entry/IPR008332 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR014048 http://www.ebi.ac.uk/interpro/entry/IPR014048 InterPro IPR023546 http://www.ebi.ac.uk/interpro/entry/IPR023546 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW1329 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1329 KEGG_Gene eco:b1335 http://www.genome.jp/dbget-bin/www_bget?eco:b1335 KEGG_Orthology KO:K00567 http://www.genome.jp/dbget-bin/www_bget?KO:K00567 MINT MINT-1243838 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1243838 OMA EDKIATP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EDKIATP PROSITE PS00374 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00374 PSORT swissprot:OGT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:OGT_ECOLI PSORT-B swissprot:OGT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:OGT_ECOLI PSORT2 swissprot:OGT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:OGT_ECOLI Pfam PF01035 http://pfam.xfam.org/family/PF01035 Pfam PF02870 http://pfam.xfam.org/family/PF02870 Phobius swissprot:OGT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:OGT_ECOLI PhylomeDB P0AFH0 http://phylomedb.org/?seqid=P0AFH0 ProteinModelPortal P0AFH0 http://www.proteinmodelportal.org/query/uniprot/P0AFH0 PubMed 1520330 http://www.ncbi.nlm.nih.gov/pubmed/1520330 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2825131 http://www.ncbi.nlm.nih.gov/pubmed/2825131 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415851 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415851 RefSeq WP_000945011 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000945011 SMR P0AFH0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFH0 STRING 511145.b1335 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1335&targetmode=cogs STRING COG0350 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0350&targetmode=cogs SUPFAM SSF46767 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46767 SUPFAM SSF53155 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53155 TIGRFAMs TIGR00589 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00589 UniProtKB OGT_ECOLI http://www.uniprot.org/uniprot/OGT_ECOLI UniProtKB-AC P0AFH0 http://www.uniprot.org/uniprot/P0AFH0 charge swissprot:OGT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:OGT_ECOLI eggNOG COG0350 http://eggnogapi.embl.de/nog_data/html/tree/COG0350 eggNOG ENOG4105K85 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K85 epestfind swissprot:OGT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:OGT_ECOLI garnier swissprot:OGT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:OGT_ECOLI helixturnhelix swissprot:OGT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:OGT_ECOLI hmoment swissprot:OGT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:OGT_ECOLI iep swissprot:OGT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:OGT_ECOLI inforesidue swissprot:OGT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:OGT_ECOLI octanol swissprot:OGT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:OGT_ECOLI pepcoil swissprot:OGT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:OGT_ECOLI pepdigest swissprot:OGT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:OGT_ECOLI pepinfo swissprot:OGT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:OGT_ECOLI pepnet swissprot:OGT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:OGT_ECOLI pepstats swissprot:OGT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:OGT_ECOLI pepwheel swissprot:OGT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:OGT_ECOLI pepwindow swissprot:OGT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:OGT_ECOLI sigcleave swissprot:OGT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:OGT_ECOLI ## Database ID URL or Descriptions # InterPro IPR009913 TraP # Organism TRAP_ECOLI Escherichia coli (strain K12) # Pfam PF07296 TraP # RecName TRAP_ECOLI Protein TraP # RefSeq NP_061458 NC_002483.1 # RefSeq NP_862924 NC_004998.1 # RefSeq WP_000002792 NZ_CP014273.1 # RefSeq YP_009060151 NC_024956.1 # RefSeq YP_009068346 NC_025139.1 # RefSeq YP_009070611 NC_025175.1 BLAST swissprot:TRAP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRAP_ECOLI EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL U01159 http://www.ebi.ac.uk/ena/data/view/U01159 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1263570 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263570 GeneID 1446488 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1446488 GeneID 20467920 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20467920 GeneID 20491476 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20491476 GeneID 20492679 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20492679 InterPro IPR009913 http://www.ebi.ac.uk/interpro/entry/IPR009913 OMA YMSFAAG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YMSFAAG PSORT swissprot:TRAP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRAP_ECOLI PSORT-B swissprot:TRAP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRAP_ECOLI PSORT2 swissprot:TRAP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRAP_ECOLI Pfam PF07296 http://pfam.xfam.org/family/PF07296 Phobius swissprot:TRAP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRAP_ECOLI ProteinModelPortal P41068 http://www.proteinmodelportal.org/query/uniprot/P41068 PubMed 7915817 http://www.ncbi.nlm.nih.gov/pubmed/7915817 RefSeq NP_061458 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061458 RefSeq NP_862924 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_862924 RefSeq WP_000002792 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000002792 RefSeq YP_009060151 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009060151 RefSeq YP_009068346 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009068346 RefSeq YP_009070611 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009070611 UniProtKB TRAP_ECOLI http://www.uniprot.org/uniprot/TRAP_ECOLI UniProtKB-AC P41068 http://www.uniprot.org/uniprot/P41068 charge swissprot:TRAP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRAP_ECOLI epestfind swissprot:TRAP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRAP_ECOLI garnier swissprot:TRAP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRAP_ECOLI helixturnhelix swissprot:TRAP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRAP_ECOLI hmoment swissprot:TRAP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRAP_ECOLI iep swissprot:TRAP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRAP_ECOLI inforesidue swissprot:TRAP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRAP_ECOLI octanol swissprot:TRAP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRAP_ECOLI pepcoil swissprot:TRAP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRAP_ECOLI pepdigest swissprot:TRAP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRAP_ECOLI pepinfo swissprot:TRAP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRAP_ECOLI pepnet swissprot:TRAP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRAP_ECOLI pepstats swissprot:TRAP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRAP_ECOLI pepwheel swissprot:TRAP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRAP_ECOLI pepwindow swissprot:TRAP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRAP_ECOLI sigcleave swissprot:TRAP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRAP_ECOLI ## Database ID URL or Descriptions # DISRUPTION PHENOTYPE Cells lacking this gene are not able to produce enough enterobactin for efficient growth. {ECO:0000269|PubMed 20845982}. # EcoGene EG14353 ybdZ # FUNCTION YBDZ_ECOLI Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3-dihydroxybenzoyl)-serine. Plays a role in the catalytic function of EntF. It is required for adenylation of amino acids in non-ribosomal peptide biosynthesis. {ECO 0000269|PubMed 20845982}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_process GO:0009239 enterobactin biosynthetic process; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0019748 secondary metabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0051186 cofactor metabolic process # InterPro IPR005153 MbtH # Organism YBDZ_ECOLI Escherichia coli (strain K12) # PATRIC 32116344 VBIEscCol129921_0612 # PDB 5JA1 X-ray; 3.00 A; B=1-72 # PIR B31958 Q3ECFS # Pfam PF03621 MbtH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Enterobactin biosynthesis protein YbdZ {ECO:0000305|PubMed 20845982} # RefSeq WP_000885798 NZ_LN832404.1 # RefSeq YP_588441 NC_000913.3 # SIMILARITY Belongs to the MbtH-like family. {ECO 0000305}. # SMART SM00923 MbtH # eggNOG COG3251 LUCA # eggNOG ENOG41085A6 Bacteria BLAST swissprot:YBDZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBDZ_ECOLI BioCyc ECOL316407:JW0577-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0577-MONOMER BioCyc EcoCyc:MONOMER0-2659 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2659 DOI 10.1021/bi00225a027 http://dx.doi.org/10.1021/bi00225a027 DOI 10.1021/bi1012854 http://dx.doi.org/10.1021/bi1012854 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J04216 http://www.ebi.ac.uk/ena/data/view/J04216 EMBL M60177 http://www.ebi.ac.uk/ena/data/view/M60177 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4099 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4099 EcoGene EG14353 http://www.ecogene.org/geneInfo.php?eg_id=EG14353 EnsemblBacteria ABD18641 http://www.ensemblgenomes.org/id/ABD18641 EnsemblBacteria ABD18641 http://www.ensemblgenomes.org/id/ABD18641 EnsemblBacteria BAE76340 http://www.ensemblgenomes.org/id/BAE76340 EnsemblBacteria BAE76340 http://www.ensemblgenomes.org/id/BAE76340 EnsemblBacteria BAE76340 http://www.ensemblgenomes.org/id/BAE76340 EnsemblBacteria b4511 http://www.ensemblgenomes.org/id/b4511 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_process GO:0009239 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009239 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0019748 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019748 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GeneID 1450243 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1450243 HOGENOM HOG000249284 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000249284&db=HOGENOM6 InParanoid P18393 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P18393 IntAct P18393 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P18393* InterPro IPR005153 http://www.ebi.ac.uk/interpro/entry/IPR005153 KEGG_Gene ecj:JW0577 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0577 KEGG_Gene eco:b4511 http://www.genome.jp/dbget-bin/www_bget?eco:b4511 OMA HWQDMRP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HWQDMRP PDB 5JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JA1 PDBsum 5JA1 http://www.ebi.ac.uk/pdbsum/5JA1 PSORT swissprot:YBDZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBDZ_ECOLI PSORT-B swissprot:YBDZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBDZ_ECOLI PSORT2 swissprot:YBDZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBDZ_ECOLI Pfam PF03621 http://pfam.xfam.org/family/PF03621 Phobius swissprot:YBDZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBDZ_ECOLI PhylomeDB P18393 http://phylomedb.org/?seqid=P18393 ProteinModelPortal P18393 http://www.proteinmodelportal.org/query/uniprot/P18393 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1826089 http://www.ncbi.nlm.nih.gov/pubmed/1826089 PubMed 20845982 http://www.ncbi.nlm.nih.gov/pubmed/20845982 PubMed 2974033 http://www.ncbi.nlm.nih.gov/pubmed/2974033 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000885798 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000885798 RefSeq YP_588441 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_588441 SMART SM00923 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00923 SMR P18393 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P18393 STRING 511145.b4511 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4511&targetmode=cogs UniProtKB YBDZ_ECOLI http://www.uniprot.org/uniprot/YBDZ_ECOLI UniProtKB-AC P18393 http://www.uniprot.org/uniprot/P18393 charge swissprot:YBDZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBDZ_ECOLI eggNOG COG3251 http://eggnogapi.embl.de/nog_data/html/tree/COG3251 eggNOG ENOG41085A6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41085A6 epestfind swissprot:YBDZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBDZ_ECOLI garnier swissprot:YBDZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBDZ_ECOLI helixturnhelix swissprot:YBDZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBDZ_ECOLI hmoment swissprot:YBDZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBDZ_ECOLI iep swissprot:YBDZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBDZ_ECOLI inforesidue swissprot:YBDZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBDZ_ECOLI octanol swissprot:YBDZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBDZ_ECOLI pepcoil swissprot:YBDZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBDZ_ECOLI pepdigest swissprot:YBDZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBDZ_ECOLI pepinfo swissprot:YBDZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBDZ_ECOLI pepnet swissprot:YBDZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBDZ_ECOLI pepstats swissprot:YBDZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBDZ_ECOLI pepwheel swissprot:YBDZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBDZ_ECOLI pepwindow swissprot:YBDZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBDZ_ECOLI sigcleave swissprot:YBDZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBDZ_ECOLI ## Database ID URL or Descriptions # EcoGene EG14179 yffR # Organism YFFR_ECOLI Escherichia coli (strain K12) # PATRIC 32120279 VBIEscCol129921_2542 # PIR H65019 H65019 # Proteomes UP000000625 Chromosome # RecName YFFR_ECOLI Uncharacterized protein YffR # RefSeq NP_416944 NC_000913.3 # RefSeq WP_000865921 NZ_CP014272.1 BLAST swissprot:YFFR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFFR_ECOLI BioCyc EcoCyc:G7279-MONOMER http://biocyc.org/getid?id=EcoCyc:G7279-MONOMER DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3931 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3931 EcoGene EG14179 http://www.ecogene.org/geneInfo.php?eg_id=EG14179 EnsemblBacteria AAC75502 http://www.ensemblgenomes.org/id/AAC75502 EnsemblBacteria AAC75502 http://www.ensemblgenomes.org/id/AAC75502 EnsemblBacteria b2449 http://www.ensemblgenomes.org/id/b2449 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946931 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946931 KEGG_Gene eco:b2449 http://www.genome.jp/dbget-bin/www_bget?eco:b2449 PSORT swissprot:YFFR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFFR_ECOLI PSORT-B swissprot:YFFR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFFR_ECOLI PSORT2 swissprot:YFFR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFFR_ECOLI Phobius swissprot:YFFR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFFR_ECOLI ProteinModelPortal P76549 http://www.proteinmodelportal.org/query/uniprot/P76549 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416944 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416944 RefSeq WP_000865921 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000865921 STRING 511145.b2449 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2449&targetmode=cogs UniProtKB YFFR_ECOLI http://www.uniprot.org/uniprot/YFFR_ECOLI UniProtKB-AC P76549 http://www.uniprot.org/uniprot/P76549 charge swissprot:YFFR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFFR_ECOLI epestfind swissprot:YFFR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFFR_ECOLI garnier swissprot:YFFR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFFR_ECOLI helixturnhelix swissprot:YFFR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFFR_ECOLI hmoment swissprot:YFFR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFFR_ECOLI iep swissprot:YFFR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFFR_ECOLI inforesidue swissprot:YFFR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFFR_ECOLI octanol swissprot:YFFR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFFR_ECOLI pepcoil swissprot:YFFR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFFR_ECOLI pepdigest swissprot:YFFR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFFR_ECOLI pepinfo swissprot:YFFR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFFR_ECOLI pepnet swissprot:YFFR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFFR_ECOLI pepstats swissprot:YFFR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFFR_ECOLI pepwheel swissprot:YFFR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFFR_ECOLI pepwindow swissprot:YFFR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFFR_ECOLI sigcleave swissprot:YFFR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFFR_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=339 uM for CDP-ME2P (at pH 7.4) {ECO 0000269|PubMed:22839733}; Note=kcat is 61 min(-1) for CDP-ME2P (at pH 7.4).; # BRENDA 4.6.1.12 2026 # BioGrid 4262279 275 # CATALYTIC ACTIVITY ISPF_ECOLI 2-phospho-4-(cytidine 5'-diphospho)-2-C- methyl-D-erythritol = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + CMP. {ECO 0000269|PubMed 10694574, ECO 0000269|PubMed 22839733}. # CDD cd00554 MECDP_synthase # COFACTOR ISPF_ECOLI Name=a divalent metal cation; Xref=ChEBI CHEBI 60240; Evidence={ECO 0000269|PubMed 10694574, ECO 0000269|PubMed 11786530, ECO 0000269|PubMed 11829504, ECO 0000269|PubMed 11997478, ECO 0000269|PubMed 15608374, ECO 0000269|PubMed 16392111, ECO 0000269|PubMed 16511114, ECO 0000269|PubMed 19320487}; Note=Binds 1 divalent metal cation per subunit. {ECO 0000269|PubMed 10694574, ECO 0000269|PubMed 11786530, ECO 0000269|PubMed 11829504, ECO 0000269|PubMed 11997478, ECO 0000269|PubMed 15608374, ECO 0000269|PubMed 16392111, ECO 0000269|PubMed 16511114, ECO 0000269|PubMed 19320487}; # DISRUPTION PHENOTYPE Cells lacking this gene reveal a filamentous phenotype. {ECO:0000269|PubMed 12270818}. # ENZYME REGULATION Activated by 2C-methyl-D-erythritol 4-phosphate (MEP). {ECO:0000269|PubMed 22839733}. # EcoGene EG11816 ispF # FUNCTION ISPF_ECOLI Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). Also converts 4-diphosphocytidyl-2-C-methyl-D-erythritol into 2-C- methyl-D-erythritol 3,4-cyclophosphate and CMP. {ECO 0000269|PubMed 10694574, ECO 0000269|PubMed 22839733}. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_function GO:0008685 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity; IDA:EcoCyc. # GO_function GO:0030145 manganese ion binding; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IDA:EcoCyc. # GO_process GO:0006744 ubiquinone biosynthetic process; IDA:EcoCyc. # GO_process GO:0016114 terpenoid biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0019288 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway; IEA:UniProtKB-UniPathway. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.30.1330.50 -; 1. # HAMAP MF_00107 IspF # IntAct P62617 7 # InterPro IPR003526 MECDP_synthase # InterPro IPR020555 MECDP_synthase_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00900 Terpenoid backbone biosynthesis # Organism ISPF_ECOLI Escherichia coli (strain K12) # PATHWAY Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1- deoxy-D-xylulose 5-phosphate step 4/6. # PATRIC 32120898 VBIEscCol129921_2841 # PDB 1GX1 X-ray; 1.80 A; A/B/C=1-159 # PDB 1H47 X-ray; 2.00 A; A/B/C/D/E/F=1-159 # PDB 1H48 X-ray; 2.30 A; A/B/C/D/E/F=1-159 # PDB 1JY8 X-ray; 2.50 A; A=1-159 # PDB 1KNJ X-ray; 2.80 A; A=1-159 # PDB 1KNK X-ray; 2.80 A; A=1-159 # PDB 1U3L X-ray; 2.50 A; A=1-159 # PDB 1U3P X-ray; 2.85 A; A=1-159 # PDB 1U40 X-ray; 2.80 A; A=1-159 # PDB 1U43 X-ray; 3.20 A; A=1-159 # PDB 1YQN X-ray; 3.11 A; A=1-159 # PDB 2AMT X-ray; 2.30 A; A/B/C/D/E/F=1-159 # PDB 2GZL X-ray; 2.50 A; A=1-157 # PDB 3ELC X-ray; 2.50 A; A/B/C=1-159 # PDB 3EOR X-ray; 2.90 A; A=1-159 # PDB 3ERN X-ray; 2.10 A; A/B/C/D/E/F=1-159 # PDB 3ESJ X-ray; 2.70 A; A=1-159 # PDB 3FBA X-ray; 3.10 A; A=1-159 # PIR I55083 I55083 # PROSITE PS01350 ISPF # Pfam PF02542 YgbB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ISPF_ECOLI 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase # RefSeq NP_417226 NC_000913.3 # RefSeq WP_001219242 NZ_LN832404.1 # SIMILARITY Belongs to the IspF family. {ECO 0000305}. # SUBUNIT ISPF_ECOLI Homotrimer. {ECO 0000269|PubMed 11786530, ECO 0000269|PubMed 11829504, ECO 0000269|PubMed 11997478, ECO 0000269|PubMed 15608374, ECO 0000269|PubMed 16392111, ECO 0000269|PubMed 16511114, ECO 0000269|PubMed 19320487}. # SUPFAM SSF69765 SSF69765 # TIGRFAMs TIGR00151 ispF # UniPathway UPA00056 UER00095 # eggNOG COG0245 LUCA # eggNOG ENOG4108UH8 Bacteria BLAST swissprot:ISPF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ISPF_ECOLI BioCyc ECOL316407:JW2716-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2716-MONOMER BioCyc EcoCyc:EG11816-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11816-MONOMER BioCyc MetaCyc:EG11816-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11816-MONOMER COG COG0245 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0245 DIP DIP-48029N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48029N DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1002/anie.200503003 http://dx.doi.org/10.1002/anie.200503003 DOI 10.1006/jmbi.2001.5341 http://dx.doi.org/10.1006/jmbi.2001.5341 DOI 10.1021/cb300243w http://dx.doi.org/10.1021/cb300243w DOI 10.1021/jm801475n http://dx.doi.org/10.1021/jm801475n DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.040554697 http://dx.doi.org/10.1073/pnas.040554697 DOI 10.1073/pnas.102679799 http://dx.doi.org/10.1073/pnas.102679799 DOI 10.1074/jbc.C100739200 http://dx.doi.org/10.1074/jbc.C100739200 DOI 10.1107/S0907444904025971 http://dx.doi.org/10.1107/S0907444904025971 DOI 10.1107/S1744309105018762 http://dx.doi.org/10.1107/S1744309105018762 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.20.5609-5618.2002 http://dx.doi.org/10.1128/JB.184.20.5609-5618.2002 EC_number EC:4.6.1.12 http://www.genome.jp/dbget-bin/www_bget?EC:4.6.1.12 EMBL AB038256 http://www.ebi.ac.uk/ena/data/view/AB038256 EMBL AF230738 http://www.ebi.ac.uk/ena/data/view/AF230738 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L07942 http://www.ebi.ac.uk/ena/data/view/L07942 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 ENZYME 4.6.1.12 http://enzyme.expasy.org/EC/4.6.1.12 EchoBASE EB1763 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1763 EcoGene EG11816 http://www.ecogene.org/geneInfo.php?eg_id=EG11816 EnsemblBacteria AAC75788 http://www.ensemblgenomes.org/id/AAC75788 EnsemblBacteria AAC75788 http://www.ensemblgenomes.org/id/AAC75788 EnsemblBacteria BAE76823 http://www.ensemblgenomes.org/id/BAE76823 EnsemblBacteria BAE76823 http://www.ensemblgenomes.org/id/BAE76823 EnsemblBacteria BAE76823 http://www.ensemblgenomes.org/id/BAE76823 EnsemblBacteria b2746 http://www.ensemblgenomes.org/id/b2746 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0008685 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008685 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006744 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006744 GO_process GO:0016114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016114 GO_process GO:0019288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019288 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.30.1330.50 http://www.cathdb.info/version/latest/superfamily/3.30.1330.50 GeneID 945057 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945057 HAMAP MF_00107 http://hamap.expasy.org/unirule/MF_00107 HOGENOM HOG000239175 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000239175&db=HOGENOM6 InParanoid P62617 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P62617 IntAct P62617 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P62617* IntEnz 4.6.1.12 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.6.1.12 InterPro IPR003526 http://www.ebi.ac.uk/interpro/entry/IPR003526 InterPro IPR020555 http://www.ebi.ac.uk/interpro/entry/IPR020555 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2716 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2716 KEGG_Gene eco:b2746 http://www.genome.jp/dbget-bin/www_bget?eco:b2746 KEGG_Orthology KO:K01770 http://www.genome.jp/dbget-bin/www_bget?KO:K01770 KEGG_Pathway ko00900 http://www.genome.jp/kegg-bin/show_pathway?ko00900 KEGG_Reaction rn:R05637 http://www.genome.jp/dbget-bin/www_bget?rn:R05637 OMA IRIGNGY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IRIGNGY PDB 1GX1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1GX1 PDB 1H47 http://www.ebi.ac.uk/pdbe-srv/view/entry/1H47 PDB 1H48 http://www.ebi.ac.uk/pdbe-srv/view/entry/1H48 PDB 1JY8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1JY8 PDB 1KNJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1KNJ PDB 1KNK http://www.ebi.ac.uk/pdbe-srv/view/entry/1KNK PDB 1U3L http://www.ebi.ac.uk/pdbe-srv/view/entry/1U3L PDB 1U3P http://www.ebi.ac.uk/pdbe-srv/view/entry/1U3P PDB 1U40 http://www.ebi.ac.uk/pdbe-srv/view/entry/1U40 PDB 1U43 http://www.ebi.ac.uk/pdbe-srv/view/entry/1U43 PDB 1YQN http://www.ebi.ac.uk/pdbe-srv/view/entry/1YQN PDB 2AMT http://www.ebi.ac.uk/pdbe-srv/view/entry/2AMT PDB 2GZL http://www.ebi.ac.uk/pdbe-srv/view/entry/2GZL PDB 3ELC http://www.ebi.ac.uk/pdbe-srv/view/entry/3ELC PDB 3EOR http://www.ebi.ac.uk/pdbe-srv/view/entry/3EOR PDB 3ERN http://www.ebi.ac.uk/pdbe-srv/view/entry/3ERN PDB 3ESJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3ESJ PDB 3FBA http://www.ebi.ac.uk/pdbe-srv/view/entry/3FBA PDBsum 1GX1 http://www.ebi.ac.uk/pdbsum/1GX1 PDBsum 1H47 http://www.ebi.ac.uk/pdbsum/1H47 PDBsum 1H48 http://www.ebi.ac.uk/pdbsum/1H48 PDBsum 1JY8 http://www.ebi.ac.uk/pdbsum/1JY8 PDBsum 1KNJ http://www.ebi.ac.uk/pdbsum/1KNJ PDBsum 1KNK http://www.ebi.ac.uk/pdbsum/1KNK PDBsum 1U3L http://www.ebi.ac.uk/pdbsum/1U3L PDBsum 1U3P http://www.ebi.ac.uk/pdbsum/1U3P PDBsum 1U40 http://www.ebi.ac.uk/pdbsum/1U40 PDBsum 1U43 http://www.ebi.ac.uk/pdbsum/1U43 PDBsum 1YQN http://www.ebi.ac.uk/pdbsum/1YQN PDBsum 2AMT http://www.ebi.ac.uk/pdbsum/2AMT PDBsum 2GZL http://www.ebi.ac.uk/pdbsum/2GZL PDBsum 3ELC http://www.ebi.ac.uk/pdbsum/3ELC PDBsum 3EOR http://www.ebi.ac.uk/pdbsum/3EOR PDBsum 3ERN http://www.ebi.ac.uk/pdbsum/3ERN PDBsum 3ESJ http://www.ebi.ac.uk/pdbsum/3ESJ PDBsum 3FBA http://www.ebi.ac.uk/pdbsum/3FBA PROSITE PS01350 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01350 PSORT swissprot:ISPF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ISPF_ECOLI PSORT-B swissprot:ISPF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ISPF_ECOLI PSORT2 swissprot:ISPF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ISPF_ECOLI Pfam PF02542 http://pfam.xfam.org/family/PF02542 Phobius swissprot:ISPF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ISPF_ECOLI PhylomeDB P62617 http://phylomedb.org/?seqid=P62617 ProteinModelPortal P62617 http://www.proteinmodelportal.org/query/uniprot/P62617 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 10694574 http://www.ncbi.nlm.nih.gov/pubmed/10694574 PubMed 11786530 http://www.ncbi.nlm.nih.gov/pubmed/11786530 PubMed 11829504 http://www.ncbi.nlm.nih.gov/pubmed/11829504 PubMed 11997478 http://www.ncbi.nlm.nih.gov/pubmed/11997478 PubMed 12270818 http://www.ncbi.nlm.nih.gov/pubmed/12270818 PubMed 15608374 http://www.ncbi.nlm.nih.gov/pubmed/15608374 PubMed 16392111 http://www.ncbi.nlm.nih.gov/pubmed/16392111 PubMed 16511114 http://www.ncbi.nlm.nih.gov/pubmed/16511114 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19320487 http://www.ncbi.nlm.nih.gov/pubmed/19320487 PubMed 22839733 http://www.ncbi.nlm.nih.gov/pubmed/22839733 PubMed 7928962 http://www.ncbi.nlm.nih.gov/pubmed/7928962 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417226 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417226 RefSeq WP_001219242 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001219242 SMR P62617 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P62617 STRING 511145.b2746 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2746&targetmode=cogs STRING COG0245 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0245&targetmode=cogs SUPFAM SSF69765 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF69765 TIGRFAMs TIGR00151 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00151 UniProtKB ISPF_ECOLI http://www.uniprot.org/uniprot/ISPF_ECOLI UniProtKB-AC P62617 http://www.uniprot.org/uniprot/P62617 charge swissprot:ISPF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ISPF_ECOLI eggNOG COG0245 http://eggnogapi.embl.de/nog_data/html/tree/COG0245 eggNOG ENOG4108UH8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UH8 epestfind swissprot:ISPF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ISPF_ECOLI garnier swissprot:ISPF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ISPF_ECOLI helixturnhelix swissprot:ISPF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ISPF_ECOLI hmoment swissprot:ISPF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ISPF_ECOLI iep swissprot:ISPF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ISPF_ECOLI inforesidue swissprot:ISPF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ISPF_ECOLI octanol swissprot:ISPF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ISPF_ECOLI pepcoil swissprot:ISPF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ISPF_ECOLI pepdigest swissprot:ISPF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ISPF_ECOLI pepinfo swissprot:ISPF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ISPF_ECOLI pepnet swissprot:ISPF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ISPF_ECOLI pepstats swissprot:ISPF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ISPF_ECOLI pepwheel swissprot:ISPF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ISPF_ECOLI pepwindow swissprot:ISPF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ISPF_ECOLI sigcleave swissprot:ISPF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ISPF_ECOLI ## Database ID URL or Descriptions # BioGrid 4263134 122 # EcoGene EG13685 ybjP # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GOslim_component GO:0005886 plasma membrane # IntAct P75818 2 # InterPro IPR024289 DUF3828 # Organism YBJP_ECOLI Escherichia coli (strain K12) # PATRIC 32116937 VBIEscCol129921_0894 # PIR A64825 A64825 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF12883 DUF3828 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBJP_ECOLI Uncharacterized lipoprotein YbjP # RefSeq NP_415386 NC_000913.3 # RefSeq WP_001270734 NZ_LN832404.1 # SUBCELLULAR LOCATION YBJP_ECOLI Cell membrane {ECO 0000305}; Lipid-anchor {ECO 0000305}. # eggNOG ENOG41064MM Bacteria # eggNOG ENOG410XZFI LUCA BLAST swissprot:YBJP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBJP_ECOLI BioCyc ECOL316407:JW0849-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0849-MONOMER BioCyc EcoCyc:G6450-MONOMER http://biocyc.org/getid?id=EcoCyc:G6450-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1432-1327.2000.01296.x http://dx.doi.org/10.1046/j.1432-1327.2000.01296.x DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3449 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3449 EcoGene EG13685 http://www.ecogene.org/geneInfo.php?eg_id=EG13685 EnsemblBacteria AAC73952 http://www.ensemblgenomes.org/id/AAC73952 EnsemblBacteria AAC73952 http://www.ensemblgenomes.org/id/AAC73952 EnsemblBacteria BAA35579 http://www.ensemblgenomes.org/id/BAA35579 EnsemblBacteria BAA35579 http://www.ensemblgenomes.org/id/BAA35579 EnsemblBacteria BAA35579 http://www.ensemblgenomes.org/id/BAA35579 EnsemblBacteria b0865 http://www.ensemblgenomes.org/id/b0865 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 945491 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945491 HOGENOM HOG000118261 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118261&db=HOGENOM6 IntAct P75818 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75818* InterPro IPR024289 http://www.ebi.ac.uk/interpro/entry/IPR024289 KEGG_Gene ecj:JW0849 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0849 KEGG_Gene eco:b0865 http://www.genome.jp/dbget-bin/www_bget?eco:b0865 OMA SACTTVE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SACTTVE PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YBJP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBJP_ECOLI PSORT-B swissprot:YBJP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBJP_ECOLI PSORT2 swissprot:YBJP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBJP_ECOLI Pfam PF12883 http://pfam.xfam.org/family/PF12883 Phobius swissprot:YBJP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBJP_ECOLI ProteinModelPortal P75818 http://www.proteinmodelportal.org/query/uniprot/P75818 PubMed 10806384 http://www.ncbi.nlm.nih.gov/pubmed/10806384 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415386 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415386 RefSeq WP_001270734 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001270734 SMR P75818 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75818 STRING 511145.b0865 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0865&targetmode=cogs UniProtKB YBJP_ECOLI http://www.uniprot.org/uniprot/YBJP_ECOLI UniProtKB-AC P75818 http://www.uniprot.org/uniprot/P75818 charge swissprot:YBJP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBJP_ECOLI eggNOG ENOG41064MM http://eggnogapi.embl.de/nog_data/html/tree/ENOG41064MM eggNOG ENOG410XZFI http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XZFI epestfind swissprot:YBJP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBJP_ECOLI garnier swissprot:YBJP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBJP_ECOLI helixturnhelix swissprot:YBJP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBJP_ECOLI hmoment swissprot:YBJP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBJP_ECOLI iep swissprot:YBJP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBJP_ECOLI inforesidue swissprot:YBJP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBJP_ECOLI octanol swissprot:YBJP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBJP_ECOLI pepcoil swissprot:YBJP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBJP_ECOLI pepdigest swissprot:YBJP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBJP_ECOLI pepinfo swissprot:YBJP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBJP_ECOLI pepnet swissprot:YBJP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBJP_ECOLI pepstats swissprot:YBJP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBJP_ECOLI pepwheel swissprot:YBJP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBJP_ECOLI pepwindow swissprot:YBJP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBJP_ECOLI sigcleave swissprot:YBJP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBJP_ECOLI ## Database ID URL or Descriptions # BioGrid 4259513 7 # CDD cd11740 YajQ_like # EcoGene EG13613 yajQ # FUNCTION YAJQ_ECOLI Binds nucleotides, may bind tRNA. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000049 tRNA binding; IDA:EcoliWiki. # GO_function GO:0005524 ATP binding; IDA:EcoliWiki. # GO_function GO:0005525 GTP binding; IDA:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # HAMAP MF_00632 UPF0234 # INTERACTION YAJQ_ECOLI P0A9I5 napD; NbExp=2; IntAct=EBI-370752, EBI-554985; # IntAct P0A8E7 5 # InterPro IPR007551 DUF520 # Organism YAJQ_ECOLI Escherichia coli (strain K12) # PATRIC 32116003 VBIEscCol129921_0443 # PIR B64772 B64772 # Pfam PF04461 DUF520 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAJQ_ECOLI UPF0234 protein YajQ # RefSeq NP_414960 NC_000913.3 # RefSeq WP_001138904 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40182.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the UPF0234 family. {ECO 0000305}. # SUBUNIT Monomer. {ECO:0000269|PubMed 12381839}. # SUPFAM SSF89963 SSF89963; 2 # eggNOG COG1666 LUCA # eggNOG ENOG4108VPT Bacteria BLAST swissprot:YAJQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAJQ_ECOLI BioCyc ECOL316407:JW5058-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5058-MONOMER BioCyc EcoCyc:G6240-MONOMER http://biocyc.org/getid?id=EcoCyc:G6240-MONOMER COG COG1666 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1666 DIP DIP-31840N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31840N DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1110/ps.0217502 http://dx.doi.org/10.1110/ps.0217502 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EchoBASE EB3379 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3379 EcoGene EG13613 http://www.ecogene.org/geneInfo.php?eg_id=EG13613 EnsemblBacteria AAC73529 http://www.ensemblgenomes.org/id/AAC73529 EnsemblBacteria AAC73529 http://www.ensemblgenomes.org/id/AAC73529 EnsemblBacteria BAE76206 http://www.ensemblgenomes.org/id/BAE76206 EnsemblBacteria BAE76206 http://www.ensemblgenomes.org/id/BAE76206 EnsemblBacteria BAE76206 http://www.ensemblgenomes.org/id/BAE76206 EnsemblBacteria b0426 http://www.ensemblgenomes.org/id/b0426 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000049 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 945063 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945063 HAMAP MF_00632 http://hamap.expasy.org/unirule/MF_00632 HOGENOM HOG000249184 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000249184&db=HOGENOM6 InParanoid P0A8E7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8E7 IntAct P0A8E7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8E7* InterPro IPR007551 http://www.ebi.ac.uk/interpro/entry/IPR007551 KEGG_Gene ecj:JW5058 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5058 KEGG_Gene eco:b0426 http://www.genome.jp/dbget-bin/www_bget?eco:b0426 KEGG_Orthology KO:K09767 http://www.genome.jp/dbget-bin/www_bget?KO:K09767 MINT MINT-1226917 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1226917 OMA SDFDRQE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SDFDRQE PSORT swissprot:YAJQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAJQ_ECOLI PSORT-B swissprot:YAJQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAJQ_ECOLI PSORT2 swissprot:YAJQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAJQ_ECOLI Pfam PF04461 http://pfam.xfam.org/family/PF04461 Phobius swissprot:YAJQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAJQ_ECOLI PhylomeDB P0A8E7 http://phylomedb.org/?seqid=P0A8E7 ProteinModelPortal P0A8E7 http://www.proteinmodelportal.org/query/uniprot/P0A8E7 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 12381839 http://www.ncbi.nlm.nih.gov/pubmed/12381839 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414960 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414960 RefSeq WP_001138904 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001138904 SMR P0A8E7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8E7 STRING 511145.b0426 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0426&targetmode=cogs STRING COG1666 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1666&targetmode=cogs SUPFAM SSF89963 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF89963 UniProtKB YAJQ_ECOLI http://www.uniprot.org/uniprot/YAJQ_ECOLI UniProtKB-AC P0A8E7 http://www.uniprot.org/uniprot/P0A8E7 charge swissprot:YAJQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAJQ_ECOLI eggNOG COG1666 http://eggnogapi.embl.de/nog_data/html/tree/COG1666 eggNOG ENOG4108VPT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108VPT epestfind swissprot:YAJQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAJQ_ECOLI garnier swissprot:YAJQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAJQ_ECOLI helixturnhelix swissprot:YAJQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAJQ_ECOLI hmoment swissprot:YAJQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAJQ_ECOLI iep swissprot:YAJQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAJQ_ECOLI inforesidue swissprot:YAJQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAJQ_ECOLI octanol swissprot:YAJQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAJQ_ECOLI pepcoil swissprot:YAJQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAJQ_ECOLI pepdigest swissprot:YAJQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAJQ_ECOLI pepinfo swissprot:YAJQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAJQ_ECOLI pepnet swissprot:YAJQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAJQ_ECOLI pepstats swissprot:YAJQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAJQ_ECOLI pepwheel swissprot:YAJQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAJQ_ECOLI pepwindow swissprot:YAJQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAJQ_ECOLI sigcleave swissprot:YAJQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAJQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4260996 17 # EcoGene EG12114 prfC # FUNCTION RF3_ECOLI Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003924 GTPase activity; IDA:EcoCyc. # GO_function GO:0005525 GTP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0016149 translation release factor activity, codon specific; IEA:UniProtKB-HAMAP. # GO_function GO:0016150 translation release factor activity, codon nonspecific; IDA:EcoCyc. # GO_function GO:0019003 GDP binding; IDA:EcoCyc. # GO_process GO:0006415 translational termination; IDA:EcoCyc. # GO_process GO:0006449 regulation of translational termination; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003924 GTPase activity # GOslim_function GO:0008135 translation factor activity, RNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.300 -; 1. # HAMAP MF_00072 Rel_fac_3 # IntAct P0A7I4 5 # InterPro IPR000795 TF_GTP-bd_dom # InterPro IPR004161 EFTu-like_2 # InterPro IPR004548 PrfC # InterPro IPR005225 Small_GTP-bd_dom # InterPro IPR009000 Transl_B-barrel # InterPro IPR009022 EFG_III-V # InterPro IPR027417 P-loop_NTPase # InterPro IPR031157 G_TR_CS # InterPro IPR032090 RF3_C # KEGG_Brite ko03012 Translation factors # Organism RF3_ECOLI Escherichia coli (strain K12) # PATRIC 32124360 VBIEscCol129921_4520 # PDB 2H5E X-ray; 2.80 A; A/B=1-529 # PDB 2O0F EM; 15.50 A; A=1-529 # PDB 4V85 X-ray; 3.20 A; AW=1-529 # PDB 4V89 X-ray; 3.70 A; AW=1-529 # PDB 4V8O X-ray; 3.80 A; AY=1-529 # PIR I59305 I59305 # PRINTS PR00315 ELONGATNFCT # PROSITE PS00301 G_TR_1 # PROSITE PS51722 G_TR_2 # Pfam PF03144 GTP_EFTU_D2 # Pfam PF16658 RF3_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RF3_ECOLI Peptide chain release factor 3 # RefSeq NP_418792 NC_000913.3 # RefSeq WP_000175940 NZ_LN832404.1 # SIMILARITY Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily. {ECO 0000305}. # SIMILARITY Contains 1 tr-type G (guanine nucleotide-binding) domain. {ECO 0000305}. # SUBCELLULAR LOCATION RF3_ECOLI Cytoplasm. # SUPFAM SSF50447 SSF50447 # SUPFAM SSF52540 SSF52540 # SUPFAM SSF54980 SSF54980 # TIGRFAMs TIGR00231 small_GTP # TIGRFAMs TIGR00503 prfC # eggNOG COG4108 LUCA # eggNOG ENOG4105C8A Bacteria BLAST swissprot:RF3_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RF3_ECOLI BioCyc ECOL316407:JW5873-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5873-MONOMER BioCyc EcoCyc:EG12114-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12114-MONOMER COG COG0480 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0480 DIP DIP-39402N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-39402N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.91.13.5798 http://dx.doi.org/10.1073/pnas.91.13.5798 DOI 10.1073/pnas.91.13.5848 http://dx.doi.org/10.1073/pnas.91.13.5848 DOI 10.1074/jbc.270.18.10595 http://dx.doi.org/10.1074/jbc.270.18.10595 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1111/j.1432-1033.1995.732_a.x http://dx.doi.org/10.1111/j.1432-1033.1995.732_a.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D17724 http://www.ebi.ac.uk/ena/data/view/D17724 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL Z26313 http://www.ebi.ac.uk/ena/data/view/Z26313 EchoBASE EB2037 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2037 EcoGene EG12114 http://www.ecogene.org/geneInfo.php?eg_id=EG12114 EnsemblBacteria AAC77328 http://www.ensemblgenomes.org/id/AAC77328 EnsemblBacteria AAC77328 http://www.ensemblgenomes.org/id/AAC77328 EnsemblBacteria BAE78363 http://www.ensemblgenomes.org/id/BAE78363 EnsemblBacteria BAE78363 http://www.ensemblgenomes.org/id/BAE78363 EnsemblBacteria BAE78363 http://www.ensemblgenomes.org/id/BAE78363 EnsemblBacteria b4375 http://www.ensemblgenomes.org/id/b4375 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_function GO:0016149 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016149 GO_function GO:0016150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016150 GO_function GO:0019003 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019003 GO_process GO:0006415 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006415 GO_process GO:0006449 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006449 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GOslim_function GO:0008135 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008135 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948897 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948897 HAMAP MF_00072 http://hamap.expasy.org/unirule/MF_00072 HOGENOM HOG000236725 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000236725&db=HOGENOM6 InParanoid P0A7I4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7I4 IntAct P0A7I4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7I4* InterPro IPR000795 http://www.ebi.ac.uk/interpro/entry/IPR000795 InterPro IPR004161 http://www.ebi.ac.uk/interpro/entry/IPR004161 InterPro IPR004548 http://www.ebi.ac.uk/interpro/entry/IPR004548 InterPro IPR005225 http://www.ebi.ac.uk/interpro/entry/IPR005225 InterPro IPR009000 http://www.ebi.ac.uk/interpro/entry/IPR009000 InterPro IPR009022 http://www.ebi.ac.uk/interpro/entry/IPR009022 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR031157 http://www.ebi.ac.uk/interpro/entry/IPR031157 InterPro IPR032090 http://www.ebi.ac.uk/interpro/entry/IPR032090 KEGG_Brite ko03012 http://www.genome.jp/dbget-bin/www_bget?ko03012 KEGG_Gene ecj:JW5873 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5873 KEGG_Gene eco:b4375 http://www.genome.jp/dbget-bin/www_bget?eco:b4375 KEGG_Orthology KO:K02837 http://www.genome.jp/dbget-bin/www_bget?KO:K02837 MINT MINT-1229875 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1229875 OMA VIQYRLE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VIQYRLE PDB 2H5E http://www.ebi.ac.uk/pdbe-srv/view/entry/2H5E PDB 2O0F http://www.ebi.ac.uk/pdbe-srv/view/entry/2O0F PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V8O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V8O PDBsum 2H5E http://www.ebi.ac.uk/pdbsum/2H5E PDBsum 2O0F http://www.ebi.ac.uk/pdbsum/2O0F PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V8O http://www.ebi.ac.uk/pdbsum/4V8O PRINTS PR00315 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00315 PROSITE PS00301 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00301 PROSITE PS51722 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51722 PSORT swissprot:RF3_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RF3_ECOLI PSORT-B swissprot:RF3_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RF3_ECOLI PSORT2 swissprot:RF3_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RF3_ECOLI Pfam PF03144 http://pfam.xfam.org/family/PF03144 Pfam PF16658 http://pfam.xfam.org/family/PF16658 Phobius swissprot:RF3_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RF3_ECOLI PhylomeDB P0A7I4 http://phylomedb.org/?seqid=P0A7I4 ProteinModelPortal P0A7I4 http://www.proteinmodelportal.org/query/uniprot/P0A7I4 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 7737996 http://www.ncbi.nlm.nih.gov/pubmed/7737996 PubMed 8016068 http://www.ncbi.nlm.nih.gov/pubmed/8016068 PubMed 8016077 http://www.ncbi.nlm.nih.gov/pubmed/8016077 PubMed 8575429 http://www.ncbi.nlm.nih.gov/pubmed/8575429 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418792 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418792 RefSeq WP_000175940 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000175940 SMR P0A7I4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7I4 STRING 511145.b4375 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4375&targetmode=cogs STRING COG0480 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0480&targetmode=cogs SUPFAM SSF50447 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50447 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SUPFAM SSF54980 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54980 TIGRFAMs TIGR00231 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00231 TIGRFAMs TIGR00503 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00503 UniProtKB RF3_ECOLI http://www.uniprot.org/uniprot/RF3_ECOLI UniProtKB-AC P0A7I4 http://www.uniprot.org/uniprot/P0A7I4 charge swissprot:RF3_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RF3_ECOLI eggNOG COG4108 http://eggnogapi.embl.de/nog_data/html/tree/COG4108 eggNOG ENOG4105C8A http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C8A epestfind swissprot:RF3_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RF3_ECOLI garnier swissprot:RF3_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RF3_ECOLI helixturnhelix swissprot:RF3_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RF3_ECOLI hmoment swissprot:RF3_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RF3_ECOLI iep swissprot:RF3_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RF3_ECOLI inforesidue swissprot:RF3_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RF3_ECOLI octanol swissprot:RF3_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RF3_ECOLI pepcoil swissprot:RF3_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RF3_ECOLI pepdigest swissprot:RF3_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RF3_ECOLI pepinfo swissprot:RF3_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RF3_ECOLI pepnet swissprot:RF3_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RF3_ECOLI pepstats swissprot:RF3_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RF3_ECOLI pepwheel swissprot:RF3_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RF3_ECOLI pepwindow swissprot:RF3_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RF3_ECOLI sigcleave swissprot:RF3_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RF3_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES E4PD_ECOLI Kinetic parameters KM=74 uM for NAD (at 37 degrees Celsius and pH 8.6) {ECO 0000269|PubMed 7751290, ECO 0000269|PubMed 9182530}; KM=510 uM for D-erythrose 4-phosphate (at 25 degrees Celsius and pH 8.9) {ECO 0000269|PubMed 7751290, ECO 0000269|PubMed 9182530}; KM=960 uM for D-erythrose 4-phosphate (at 37 degrees Celsius and pH 8.6) {ECO 0000269|PubMed 7751290, ECO 0000269|PubMed 9182530}; KM=1100 uM for glyceraldehyde 3-phosphate (at 25 degrees Celsius and pH 8.9) {ECO 0000269|PubMed 7751290, ECO 0000269|PubMed 9182530}; Vmax=91.2 umol/min/mg enzyme toward D-erythrose 4-phosphate (at 37 degrees Celsius and pH 8.6) {ECO 0000269|PubMed 7751290, ECO 0000269|PubMed 9182530}; Vmax=77.2 umol/min/mg enzyme toward NAD (at 37 degrees Celsius and pH 8.6) {ECO 0000269|PubMed 7751290, ECO 0000269|PubMed 9182530}; pH dependence Optimum pH is about 8.6. {ECO 0000269|PubMed 7751290, ECO 0000269|PubMed 9182530}; Temperature dependence Optimum temperature is 50 degrees Celsius at pH 8.6. Relatively thermostable. Activity begins to decrease significantly when E4PDH is incubated at 50 degrees Celsius for 5 min. {ECO 0000269|PubMed 7751290, ECO 0000269|PubMed 9182530}; # BRENDA 1.2.1.72 2026 # BioGrid 4262067 5 # CATALYTIC ACTIVITY D-erythrose 4-phosphate + NAD(+) + H(2)O = 4- phosphoerythronate + NADH. {ECO:0000269|PubMed 7751290}. # CAUTION E4PD_ECOLI Was originally (PubMed 2546007 and PubMed 2124629) thought to be a glyceraldehyde 3-phosphate dehydrogenase, but glyceraldehyde 3-phosphate is not an efficient substrate (PubMed 7751290 and PubMed 9182530). {ECO 0000305}. # EcoGene EG10368 epd # FUNCTION E4PD_ECOLI Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate. {ECO 0000269|PubMed 9182530, ECO 0000269|PubMed 9696782}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity; IDA:EcoCyc. # GO_function GO:0048001 erythrose-4-phosphate dehydrogenase activity; IDA:EcoCyc. # GO_function GO:0051287 NAD binding; IDA:EcoCyc. # GO_process GO:0006006 glucose metabolic process; IDA:EcoCyc. # GO_process GO:0008615 pyridoxine biosynthetic process; IMP:EcoCyc. # GO_process GO:0042823 pyridoxal phosphate biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.720 -; 1. # HAMAP MF_01640 E4P_dehydrog # IntAct P0A9B6 2 # InterPro IPR006422 E4P_DH_bac # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR020828 GlycerAld_3-P_DH_NAD(P)-bd # InterPro IPR020829 GlycerAld_3-P_DH_cat # InterPro IPR020830 GlycerAld_3-P_DH_AS # InterPro IPR020831 GlycerAld/Erythrose_P_DH # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00750 Vitamin B6 metabolism # MASS SPECTROMETRY Mass=37170; Method=Unknown; Range=2-339; Evidence={ECO:0000269|PubMed 9182530}; # Organism E4PD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10836 PTHR10836 # PATHWAY Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4- phosphate step 1/5. # PATRIC 32121268 VBIEscCol129921_3022 # PDB 2X5J X-ray; 2.30 A; O/P/Q/R=1-339 # PDB 2X5K X-ray; 2.37 A; O/P/Q/R=1-339 # PDB 2XF8 X-ray; 2.95 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P=2-339 # PIR S04732 DEECGB # PIRSF PIRSF000149 GAP_DH # PRINTS PR00078 G3PDHDRGNASE # PROSITE PS00071 GAPDH # Pfam PF00044 Gp_dh_N # Pfam PF02800 Gp_dh_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName E4PD_ECOLI D-erythrose-4-phosphate dehydrogenase # RefSeq NP_417402 NC_000913.3 # RefSeq WP_000218480 NZ_LN832404.1 # SIMILARITY Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily. {ECO 0000305}. # SMART SM00846 Gp_dh_N # SUBCELLULAR LOCATION E4PD_ECOLI Cytoplasm. # SUBUNIT Homotetramer. {ECO:0000269|PubMed 7751290}. # SUPFAM SSF51735 SSF51735 # TIGRFAMs TIGR01532 E4PD_g-proteo # UniPathway UPA00244 UER00309 # eggNOG COG0057 LUCA # eggNOG ENOG4105C17 Bacteria BLAST swissprot:E4PD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:E4PD_ECOLI BioCyc ECOL316407:JW2894-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2894-MONOMER BioCyc EcoCyc:ERYTH4PDEHYDROG-MONOMER http://biocyc.org/getid?id=EcoCyc:ERYTH4PDEHYDROG-MONOMER BioCyc MetaCyc:ERYTH4PDEHYDROG-MONOMER http://biocyc.org/getid?id=MetaCyc:ERYTH4PDEHYDROG-MONOMER COG COG0057 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0057 DIP DIP-9520N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9520N DOI 10.1007/BF02106053 http://dx.doi.org/10.1007/BF02106053 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.272.24.15106 http://dx.doi.org/10.1074/jbc.272.24.15106 DOI 10.1111/j.1365-2958.1989.tb00221.x http://dx.doi.org/10.1111/j.1365-2958.1989.tb00221.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.2.1.72 http://www.genome.jp/dbget-bin/www_bget?EC:1.2.1.72 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EMBL X14436 http://www.ebi.ac.uk/ena/data/view/X14436 ENZYME 1.2.1.72 http://enzyme.expasy.org/EC/1.2.1.72 EchoBASE EB0363 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0363 EcoGene EG10368 http://www.ecogene.org/geneInfo.php?eg_id=EG10368 EnsemblBacteria AAC75964 http://www.ensemblgenomes.org/id/AAC75964 EnsemblBacteria AAC75964 http://www.ensemblgenomes.org/id/AAC75964 EnsemblBacteria BAE76991 http://www.ensemblgenomes.org/id/BAE76991 EnsemblBacteria BAE76991 http://www.ensemblgenomes.org/id/BAE76991 EnsemblBacteria BAE76991 http://www.ensemblgenomes.org/id/BAE76991 EnsemblBacteria b2927 http://www.ensemblgenomes.org/id/b2927 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004365 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004365 GO_function GO:0048001 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048001 GO_function GO:0051287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051287 GO_process GO:0006006 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006006 GO_process GO:0008615 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008615 GO_process GO:0042823 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042823 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 947413 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947413 HAMAP MF_01640 http://hamap.expasy.org/unirule/MF_01640 HOGENOM HOG000071679 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000071679&db=HOGENOM6 InParanoid P0A9B6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9B6 IntAct P0A9B6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9B6* IntEnz 1.2.1.72 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.2.1.72 InterPro IPR006422 http://www.ebi.ac.uk/interpro/entry/IPR006422 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR020828 http://www.ebi.ac.uk/interpro/entry/IPR020828 InterPro IPR020829 http://www.ebi.ac.uk/interpro/entry/IPR020829 InterPro IPR020830 http://www.ebi.ac.uk/interpro/entry/IPR020830 InterPro IPR020831 http://www.ebi.ac.uk/interpro/entry/IPR020831 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2894 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2894 KEGG_Gene eco:b2927 http://www.genome.jp/dbget-bin/www_bget?eco:b2927 KEGG_Orthology KO:K03472 http://www.genome.jp/dbget-bin/www_bget?KO:K03472 KEGG_Pathway ko00750 http://www.genome.jp/kegg-bin/show_pathway?ko00750 KEGG_Reaction rn:R01825 http://www.genome.jp/dbget-bin/www_bget?rn:R01825 OMA YLEYTEL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YLEYTEL PANTHER PTHR10836 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10836 PDB 2X5J http://www.ebi.ac.uk/pdbe-srv/view/entry/2X5J PDB 2X5K http://www.ebi.ac.uk/pdbe-srv/view/entry/2X5K PDB 2XF8 http://www.ebi.ac.uk/pdbe-srv/view/entry/2XF8 PDBsum 2X5J http://www.ebi.ac.uk/pdbsum/2X5J PDBsum 2X5K http://www.ebi.ac.uk/pdbsum/2X5K PDBsum 2XF8 http://www.ebi.ac.uk/pdbsum/2XF8 PRINTS PR00078 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00078 PROSITE PS00071 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00071 PSORT swissprot:E4PD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:E4PD_ECOLI PSORT-B swissprot:E4PD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:E4PD_ECOLI PSORT2 swissprot:E4PD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:E4PD_ECOLI Pfam PF00044 http://pfam.xfam.org/family/PF00044 Pfam PF02800 http://pfam.xfam.org/family/PF02800 Phobius swissprot:E4PD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:E4PD_ECOLI PhylomeDB P0A9B6 http://phylomedb.org/?seqid=P0A9B6 ProteinModelPortal P0A9B6 http://www.proteinmodelportal.org/query/uniprot/P0A9B6 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2124629 http://www.ncbi.nlm.nih.gov/pubmed/2124629 PubMed 2546007 http://www.ncbi.nlm.nih.gov/pubmed/2546007 PubMed 7751290 http://www.ncbi.nlm.nih.gov/pubmed/7751290 PubMed 9182530 http://www.ncbi.nlm.nih.gov/pubmed/9182530 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9696782 http://www.ncbi.nlm.nih.gov/pubmed/9696782 RefSeq NP_417402 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417402 RefSeq WP_000218480 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000218480 SMART SM00846 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00846 SMR P0A9B6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9B6 STRING 511145.b2927 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2927&targetmode=cogs STRING COG0057 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0057&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 TIGRFAMs TIGR01532 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01532 UniProtKB E4PD_ECOLI http://www.uniprot.org/uniprot/E4PD_ECOLI UniProtKB-AC P0A9B6 http://www.uniprot.org/uniprot/P0A9B6 charge swissprot:E4PD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:E4PD_ECOLI eggNOG COG0057 http://eggnogapi.embl.de/nog_data/html/tree/COG0057 eggNOG ENOG4105C17 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C17 epestfind swissprot:E4PD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:E4PD_ECOLI garnier swissprot:E4PD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:E4PD_ECOLI helixturnhelix swissprot:E4PD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:E4PD_ECOLI hmoment swissprot:E4PD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:E4PD_ECOLI iep swissprot:E4PD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:E4PD_ECOLI inforesidue swissprot:E4PD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:E4PD_ECOLI octanol swissprot:E4PD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:E4PD_ECOLI pepcoil swissprot:E4PD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:E4PD_ECOLI pepdigest swissprot:E4PD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:E4PD_ECOLI pepinfo swissprot:E4PD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:E4PD_ECOLI pepnet swissprot:E4PD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:E4PD_ECOLI pepstats swissprot:E4PD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:E4PD_ECOLI pepwheel swissprot:E4PD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:E4PD_ECOLI pepwindow swissprot:E4PD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:E4PD_ECOLI sigcleave swissprot:E4PD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:E4PD_ECOLI ## Database ID URL or Descriptions # BioGrid 4259142 243 # CDD cd06174 MFS # EcoGene EG12369 ydjE # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IBA:GO_Central. # GO_function GO:0022891 substrate-specific transmembrane transporter activity; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # InterPro IPR005828 MFS_sugar_transport-like # InterPro IPR020846 MFS_dom # KEGG_Brite ko02000 Transporters # Organism YDJE_ECOLI Escherichia coli (strain K12) # PATRIC 32118849 VBIEscCol129921_1842 # PIR A64937 A64937 # PROSITE PS50850 MFS # Pfam PF00083 Sugar_tr # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDJE_ECOLI Inner membrane metabolite transport protein YdjE # RefSeq NP_416283 NC_000913.3 # RefSeq WP_000438807 NZ_LN832404.1 # SIMILARITY Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. {ECO 0000305}. # SUBCELLULAR LOCATION YDJE_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.1.92 the major facilitator superfamily (mfs) # eggNOG ENOG4108KUU Bacteria # eggNOG ENOG410XQKC LUCA BLAST swissprot:YDJE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDJE_ECOLI BioCyc ECOL316407:JW1758-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1758-MONOMER BioCyc EcoCyc:YDJE-MONOMER http://biocyc.org/getid?id=EcoCyc:YDJE-MONOMER COG COG0477 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0477 DOI 10.1016/0378-1119(89)90312-0 http://dx.doi.org/10.1016/0378-1119(89)90312-0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M26934 http://www.ebi.ac.uk/ena/data/view/M26934 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2272 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2272 EcoGene EG12369 http://www.ecogene.org/geneInfo.php?eg_id=EG12369 EnsemblBacteria AAC74839 http://www.ensemblgenomes.org/id/AAC74839 EnsemblBacteria AAC74839 http://www.ensemblgenomes.org/id/AAC74839 EnsemblBacteria BAA15560 http://www.ensemblgenomes.org/id/BAA15560 EnsemblBacteria BAA15560 http://www.ensemblgenomes.org/id/BAA15560 EnsemblBacteria BAA15560 http://www.ensemblgenomes.org/id/BAA15560 EnsemblBacteria b1769 http://www.ensemblgenomes.org/id/b1769 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0022891 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022891 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GeneID 946274 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946274 HOGENOM HOG000114540 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000114540&db=HOGENOM6 InParanoid P38055 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P38055 InterPro IPR005828 http://www.ebi.ac.uk/interpro/entry/IPR005828 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1758 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1758 KEGG_Gene eco:b1769 http://www.genome.jp/dbget-bin/www_bget?eco:b1769 KEGG_Orthology KO:K08369 http://www.genome.jp/dbget-bin/www_bget?KO:K08369 OMA VINGTFW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VINGTFW PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:YDJE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDJE_ECOLI PSORT-B swissprot:YDJE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDJE_ECOLI PSORT2 swissprot:YDJE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDJE_ECOLI Pfam PF00083 http://pfam.xfam.org/family/PF00083 Phobius swissprot:YDJE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDJE_ECOLI PhylomeDB P38055 http://phylomedb.org/?seqid=P38055 ProteinModelPortal P38055 http://www.proteinmodelportal.org/query/uniprot/P38055 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2670682 http://www.ncbi.nlm.nih.gov/pubmed/2670682 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416283 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416283 RefSeq WP_000438807 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000438807 STRING 511145.b1769 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1769&targetmode=cogs STRING COG0477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0477&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.1.92 http://www.tcdb.org/search/result.php?tc=2.A.1.1.92 UniProtKB YDJE_ECOLI http://www.uniprot.org/uniprot/YDJE_ECOLI UniProtKB-AC P38055 http://www.uniprot.org/uniprot/P38055 charge swissprot:YDJE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDJE_ECOLI eggNOG ENOG4108KUU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108KUU eggNOG ENOG410XQKC http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQKC epestfind swissprot:YDJE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDJE_ECOLI garnier swissprot:YDJE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDJE_ECOLI helixturnhelix swissprot:YDJE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDJE_ECOLI hmoment swissprot:YDJE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDJE_ECOLI iep swissprot:YDJE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDJE_ECOLI inforesidue swissprot:YDJE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDJE_ECOLI octanol swissprot:YDJE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDJE_ECOLI pepcoil swissprot:YDJE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDJE_ECOLI pepdigest swissprot:YDJE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDJE_ECOLI pepinfo swissprot:YDJE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDJE_ECOLI pepnet swissprot:YDJE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDJE_ECOLI pepstats swissprot:YDJE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDJE_ECOLI pepwheel swissprot:YDJE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDJE_ECOLI pepwindow swissprot:YDJE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDJE_ECOLI sigcleave swissprot:YDJE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDJE_ECOLI ## Database ID URL or Descriptions # BioGrid 4260411 14 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG14425 yoeF # GO_function GO:0005524 ATP binding; IEA:InterPro. # GO_process GO:0006576 cellular biogenic amine metabolic process; IEA:InterPro. # GOslim_function GO:0043167 ion binding # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.50.300 -; 1. # InterPro IPR012381 EutP_PduV # InterPro IPR027417 P-loop_NTPase # Organism YOEF_ECOLI Escherichia coli (strain K12) # Pfam PF10662 PduV-EutP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YOEF_ECOLI Putative uncharacterized protein YoeF # SUPFAM SSF52540 SSF52540 # eggNOG COG4917 LUCA BLAST swissprot:YOEF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YOEF_ECOLI BioCyc ECOL316407:JW5328-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5328-MONOMER BioCyc EcoCyc:MONOMER0-2678 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2678 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14425 http://www.ecogene.org/geneInfo.php?eg_id=EG14425 EnsemblBacteria BAE76567 http://www.ensemblgenomes.org/id/BAE76567 EnsemblBacteria BAE76567 http://www.ensemblgenomes.org/id/BAE76567 EnsemblBacteria BAE76567 http://www.ensemblgenomes.org/id/BAE76567 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006576 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006576 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 IntAct Q2EES3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q2EES3* InterPro IPR012381 http://www.ebi.ac.uk/interpro/entry/IPR012381 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Gene ecj:JW5328 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5328 OMA LASMEQT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LASMEQT PSORT swissprot:YOEF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YOEF_ECOLI PSORT-B swissprot:YOEF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YOEF_ECOLI PSORT2 swissprot:YOEF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YOEF_ECOLI Pfam PF10662 http://pfam.xfam.org/family/PF10662 Phobius swissprot:YOEF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YOEF_ECOLI ProteinModelPortal Q2EES3 http://www.proteinmodelportal.org/query/uniprot/Q2EES3 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB YOEF_ECOLI http://www.uniprot.org/uniprot/YOEF_ECOLI UniProtKB-AC Q2EES3 http://www.uniprot.org/uniprot/Q2EES3 charge swissprot:YOEF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YOEF_ECOLI eggNOG COG4917 http://eggnogapi.embl.de/nog_data/html/tree/COG4917 epestfind swissprot:YOEF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YOEF_ECOLI garnier swissprot:YOEF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YOEF_ECOLI helixturnhelix swissprot:YOEF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YOEF_ECOLI hmoment swissprot:YOEF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YOEF_ECOLI iep swissprot:YOEF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YOEF_ECOLI inforesidue swissprot:YOEF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YOEF_ECOLI octanol swissprot:YOEF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YOEF_ECOLI pepcoil swissprot:YOEF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YOEF_ECOLI pepdigest swissprot:YOEF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YOEF_ECOLI pepinfo swissprot:YOEF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YOEF_ECOLI pepnet swissprot:YOEF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YOEF_ECOLI pepstats swissprot:YOEF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YOEF_ECOLI pepwheel swissprot:YOEF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YOEF_ECOLI pepwindow swissprot:YOEF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YOEF_ECOLI sigcleave swissprot:YOEF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YOEF_ECOLI ## Database ID URL or Descriptions # BioGrid 4263351 15 # EcoGene EG14268 flgD # FUNCTION FLGD_ECOLI Required for flagellar hook formation. May act as a scaffolding protein. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0009424 bacterial-type flagellum hook; IBA:GO_Central. # GO_process GO:0044781 bacterial-type flagellum organization; IEA:UniProtKB-KW. # GO_process GO:0071978 bacterial-type flagellum-dependent swarming motility; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_process GO:0008150 biological_process # GOslim_process GO:0048870 cell motility # IntAct P75936 3 # InterPro IPR005648 FlgD # InterPro IPR025963 FLgD_Tudor # InterPro IPR025965 FlgD_Ig # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Pathway ko02040 Flagellar assembly # Organism FLGD_ECOLI Escherichia coli (strain K12) # PATRIC 32117391 VBIEscCol129921_1118 # PIR H64850 H64850 # Pfam PF03963 FlgD # Pfam PF13860 FlgD_ig # Pfam PF13861 FLgD_tudor # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FLGD_ECOLI Basal-body rod modification protein FlgD # RefSeq NP_415593 NC_000913.3 # RefSeq WP_000020486 NZ_LN832404.1 # SIMILARITY Belongs to the FlgD family. {ECO 0000305}. # eggNOG COG1843 LUCA # eggNOG ENOG4105W00 Bacteria BLAST swissprot:FLGD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLGD_ECOLI BioCyc ECOL316407:JW1062-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1062-MONOMER BioCyc EcoCyc:G360-MONOMER http://biocyc.org/getid?id=EcoCyc:G360-MONOMER COG COG1843 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1843 DIP DIP-9632N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9632N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4016 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4016 EcoGene EG14268 http://www.ecogene.org/geneInfo.php?eg_id=EG14268 EnsemblBacteria AAC74159 http://www.ensemblgenomes.org/id/AAC74159 EnsemblBacteria AAC74159 http://www.ensemblgenomes.org/id/AAC74159 EnsemblBacteria BAA35883 http://www.ensemblgenomes.org/id/BAA35883 EnsemblBacteria BAA35883 http://www.ensemblgenomes.org/id/BAA35883 EnsemblBacteria BAA35883 http://www.ensemblgenomes.org/id/BAA35883 EnsemblBacteria b1075 http://www.ensemblgenomes.org/id/b1075 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0009424 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009424 GO_process GO:0044781 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044781 GO_process GO:0071978 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071978 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 GeneID 945813 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945813 HOGENOM HOG000265647 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000265647&db=HOGENOM6 InParanoid P75936 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75936 IntAct P75936 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75936* InterPro IPR005648 http://www.ebi.ac.uk/interpro/entry/IPR005648 InterPro IPR025963 http://www.ebi.ac.uk/interpro/entry/IPR025963 InterPro IPR025965 http://www.ebi.ac.uk/interpro/entry/IPR025965 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW1062 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1062 KEGG_Gene eco:b1075 http://www.genome.jp/dbget-bin/www_bget?eco:b1075 KEGG_Orthology KO:K02389 http://www.genome.jp/dbget-bin/www_bget?KO:K02389 KEGG_Pathway ko02040 http://www.genome.jp/kegg-bin/show_pathway?ko02040 OMA YTWNGKD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YTWNGKD PSORT swissprot:FLGD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLGD_ECOLI PSORT-B swissprot:FLGD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLGD_ECOLI PSORT2 swissprot:FLGD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLGD_ECOLI Pfam PF03963 http://pfam.xfam.org/family/PF03963 Pfam PF13860 http://pfam.xfam.org/family/PF13860 Pfam PF13861 http://pfam.xfam.org/family/PF13861 Phobius swissprot:FLGD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLGD_ECOLI PhylomeDB P75936 http://phylomedb.org/?seqid=P75936 ProteinModelPortal P75936 http://www.proteinmodelportal.org/query/uniprot/P75936 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415593 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415593 RefSeq WP_000020486 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000020486 SMR P75936 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75936 STRING 511145.b1075 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1075&targetmode=cogs STRING COG1843 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1843&targetmode=cogs UniProtKB FLGD_ECOLI http://www.uniprot.org/uniprot/FLGD_ECOLI UniProtKB-AC P75936 http://www.uniprot.org/uniprot/P75936 charge swissprot:FLGD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLGD_ECOLI eggNOG COG1843 http://eggnogapi.embl.de/nog_data/html/tree/COG1843 eggNOG ENOG4105W00 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105W00 epestfind swissprot:FLGD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLGD_ECOLI garnier swissprot:FLGD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLGD_ECOLI helixturnhelix swissprot:FLGD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLGD_ECOLI hmoment swissprot:FLGD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLGD_ECOLI iep swissprot:FLGD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLGD_ECOLI inforesidue swissprot:FLGD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLGD_ECOLI octanol swissprot:FLGD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLGD_ECOLI pepcoil swissprot:FLGD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLGD_ECOLI pepdigest swissprot:FLGD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLGD_ECOLI pepinfo swissprot:FLGD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLGD_ECOLI pepnet swissprot:FLGD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLGD_ECOLI pepstats swissprot:FLGD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLGD_ECOLI pepwheel swissprot:FLGD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLGD_ECOLI pepwindow swissprot:FLGD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLGD_ECOLI sigcleave swissprot:FLGD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLGD_ECOLI ## Database ID URL or Descriptions # AltName EII-M-Man {ECO:0000303|PubMed 2951378} # AltName EIID-Man {ECO:0000303|PubMed 2999119} # AltName Mannose permease IID component {ECO:0000303|PubMed 2999119} # BioGrid 4259146 324 # DOMAIN PTND_ECOLI The EIID domain, with its homologous EIIC domain, forms the PTS system translocation channel and contains part of its specific substrate-binding site. {ECO 0000255|PROSITE- ProRule PRU00431}. # EcoGene EG10569 manZ # FUNCTION PTND_ECOLI The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (PubMed 2951378, PubMed 2999119). The enzyme II ManXYZ PTS system is involved in mannose transport (PubMed 2951378, PubMed 2999119). Also functions as a receptor for bacterial chemotaxis and is required for infection of the cell by bacteriophage lambda where it most likely functions as a pore for penetration of lambda DNA (PubMed 4604906, PubMed 353494). {ECO 0000269|PubMed 2951378, ECO 0000269|PubMed 2999119, ECO 0000269|PubMed 353494, ECO 0000269|PubMed 4604906}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; ISM:CACAO. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0022870 protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity; IDA:EcoCyc. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IDA:EcoCyc. # GO_process GO:0015761 mannose transport; IDA:EcoCyc. # GO_process GO:0061490 glucose import into cell; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR004704 PTS_IID_man # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00276 PTS system, mannose-specific II component # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko00051 Fructose and mannose metabolism # KEGG_Pathway ko00520 Amino sugar and nucleotide sugar metabolism # KEGG_Pathway ko02060 Phosphotransferase system (PTS) # Organism PTND_ECOLI Escherichia coli (strain K12) # PATRIC 32118957 VBIEscCol129921_1896 # PIR A30288 WQECMM # PROSITE PS51108 PTS_EIID # Pfam PF03613 EIID-AGA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PTS system mannose-specific EIID component {ECO:0000303|PubMed 2999119} # RefSeq NP_416333 NC_000913.3 # RefSeq WP_000228655 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA24445.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA15631.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Contains 1 PTS EIID domain. {ECO:0000255|PROSITE- ProRule PRU00431}. # SUBCELLULAR LOCATION PTND_ECOLI Cell inner membrane {ECO 0000305|PubMed 8774730}; Single-pass membrane protein {ECO 0000305|PubMed 8774730}. # TCDB 4.A.6.1 the pts mannose-fructose-sorbose (man) family # TIGRFAMs TIGR00828 EIID-AGA # eggNOG COG3716 LUCA # eggNOG ENOG4105F3R Bacteria BLAST swissprot:PTND_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTND_ECOLI BioCyc ECOL316407:JW1808-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1808-MONOMER BioCyc EcoCyc:MANZ-MONOMER http://biocyc.org/getid?id=EcoCyc:MANZ-MONOMER BioCyc MetaCyc:MANZ-MONOMER http://biocyc.org/getid?id=MetaCyc:MANZ-MONOMER COG COG3716 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3716 DOI 10.1007/BF00266608 http://dx.doi.org/10.1007/BF00266608 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.71.7.2895 http://dx.doi.org/10.1073/pnas.71.7.2895 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1111/j.1432-1033.1996.0810u.x http://dx.doi.org/10.1111/j.1432-1033.1996.0810u.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1515/bchm3.1994.375.8.551 http://dx.doi.org/10.1515/bchm3.1994.375.8.551 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J02699 http://www.ebi.ac.uk/ena/data/view/J02699 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0564 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0564 EcoGene EG10569 http://www.ecogene.org/geneInfo.php?eg_id=EG10569 EnsemblBacteria AAC74889 http://www.ensemblgenomes.org/id/AAC74889 EnsemblBacteria AAC74889 http://www.ensemblgenomes.org/id/AAC74889 EnsemblBacteria BAA15631 http://www.ensemblgenomes.org/id/BAA15631 EnsemblBacteria BAA15631 http://www.ensemblgenomes.org/id/BAA15631 EnsemblBacteria BAA15631 http://www.ensemblgenomes.org/id/BAA15631 EnsemblBacteria b1819 http://www.ensemblgenomes.org/id/b1819 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0022870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022870 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GO_process GO:0015761 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015761 GO_process GO:0061490 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061490 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 946342 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946342 HOGENOM HOG000098670 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000098670&db=HOGENOM6 InParanoid P69805 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P69805 IntAct P69805 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69805* InterPro IPR004704 http://www.ebi.ac.uk/interpro/entry/IPR004704 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1808 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1808 KEGG_Gene eco:b1819 http://www.genome.jp/dbget-bin/www_bget?eco:b1819 KEGG_Orthology KO:K02796 http://www.genome.jp/dbget-bin/www_bget?KO:K02796 KEGG_Pathway ko00051 http://www.genome.jp/kegg-bin/show_pathway?ko00051 KEGG_Pathway ko00520 http://www.genome.jp/kegg-bin/show_pathway?ko00520 KEGG_Pathway ko02060 http://www.genome.jp/kegg-bin/show_pathway?ko02060 KEGG_Reaction rn:R02630 http://www.genome.jp/dbget-bin/www_bget?rn:R02630 PROSITE PS51108 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51108 PSORT swissprot:PTND_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTND_ECOLI PSORT-B swissprot:PTND_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTND_ECOLI PSORT2 swissprot:PTND_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTND_ECOLI Pfam PF03613 http://pfam.xfam.org/family/PF03613 Phobius swissprot:PTND_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTND_ECOLI ProteinModelPortal P69805 http://www.proteinmodelportal.org/query/uniprot/P69805 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2951378 http://www.ncbi.nlm.nih.gov/pubmed/2951378 PubMed 2999119 http://www.ncbi.nlm.nih.gov/pubmed/2999119 PubMed 353494 http://www.ncbi.nlm.nih.gov/pubmed/353494 PubMed 4604906 http://www.ncbi.nlm.nih.gov/pubmed/4604906 PubMed 7811395 http://www.ncbi.nlm.nih.gov/pubmed/7811395 PubMed 8774730 http://www.ncbi.nlm.nih.gov/pubmed/8774730 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416333 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416333 RefSeq WP_000228655 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000228655 STRING 511145.b1819 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1819&targetmode=cogs STRING COG3716 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3716&targetmode=cogs TCDB 4.A.6.1 http://www.tcdb.org/search/result.php?tc=4.A.6.1 TIGRFAMs TIGR00828 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00828 UniProtKB PTND_ECOLI http://www.uniprot.org/uniprot/PTND_ECOLI UniProtKB-AC P69805 http://www.uniprot.org/uniprot/P69805 charge swissprot:PTND_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTND_ECOLI eggNOG COG3716 http://eggnogapi.embl.de/nog_data/html/tree/COG3716 eggNOG ENOG4105F3R http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F3R epestfind swissprot:PTND_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTND_ECOLI garnier swissprot:PTND_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTND_ECOLI helixturnhelix swissprot:PTND_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTND_ECOLI hmoment swissprot:PTND_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTND_ECOLI iep swissprot:PTND_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTND_ECOLI inforesidue swissprot:PTND_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTND_ECOLI octanol swissprot:PTND_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTND_ECOLI pepcoil swissprot:PTND_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTND_ECOLI pepdigest swissprot:PTND_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTND_ECOLI pepinfo swissprot:PTND_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTND_ECOLI pepnet swissprot:PTND_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTND_ECOLI pepstats swissprot:PTND_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTND_ECOLI pepwheel swissprot:PTND_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTND_ECOLI pepwindow swissprot:PTND_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTND_ECOLI sigcleave swissprot:PTND_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTND_ECOLI ## Database ID URL or Descriptions # AltName PGPC_ECOLI Phosphatidylglycerolphosphate phosphatase C # BioGrid 4261368 6 # CATALYTIC ACTIVITY Phosphatidylglycerophosphate + H(2)O = phosphatidylglycerol + phosphate. {ECO:0000269|PubMed 21148555}. # COFACTOR PGPC_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 21148555}; # DISRUPTION PHENOTYPE No visible phenotype. Simultaneous deletion of pgpC and pgpA increases phosphatidylglycerophosphate (PGP) levels almost hundredfold relative to wild-type. In constrast, simultaneous deletion of pgpC and pgpB leads to a twofold increase of PGP levels. Lethal when combined with deletion of both pgpA and pgpB. {ECO:0000269|PubMed 21148555}. # EcoGene EG11371 yfhB # FUNCTION PGPC_ECOLI Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). {ECO 0000269|PubMed 21148555}. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_function GO:0008962 phosphatidylglycerophosphatase activity; IMP:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006655 phosphatidylglycerol biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0009395 phospholipid catabolic process; IEA:UniProtKB-KW. # GO_process GO:0046474 glycerophospholipid biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.1000 -; 2. # InterPro IPR006435 HAD-SF_hydro_IF_YfhB # InterPro IPR023214 HAD-like_dom # Organism PGPC_ECOLI Escherichia coli (strain K12) # PATHWAY Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol step 2/2. # PATRIC 32120519 VBIEscCol129921_2662 # PIR S20973 S20973 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PGPC_ECOLI Phosphatidylglycerophosphatase C # RefSeq NP_417055 NC_000913.3 # RefSeq WP_000190655 NZ_CP014272.1 # SEQUENCE CAUTION Sequence=AAA79822.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA10910.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=CAA51063.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; # SUBCELLULAR LOCATION PGPC_ECOLI Cell inner membrane {ECO 0000269|PubMed 21148555}; Single-pass membrane protein {ECO 0000269|PubMed 21148555}. # SUPFAM SSF56784 SSF56784 # TIGRFAMs TIGR01545 YfhB_g-proteo # UniPathway UPA00084 UER00504 # eggNOG COG0560 LUCA # eggNOG ENOG4105HYY Bacteria BLAST swissprot:PGPC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PGPC_ECOLI BioCyc ECOL316407:JW5408-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5408-MONOMER BioCyc EcoCyc:EG11371-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11371-MONOMER BioCyc MetaCyc:EG11371-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11371-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M110.199265 http://dx.doi.org/10.1074/jbc.M110.199265 DOI 10.1111/j.1365-2958.1992.tb01540.x http://dx.doi.org/10.1111/j.1365-2958.1992.tb01540.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.3.27 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.27 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D64044 http://www.ebi.ac.uk/ena/data/view/D64044 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36841 http://www.ebi.ac.uk/ena/data/view/U36841 EMBL X72336 http://www.ebi.ac.uk/ena/data/view/X72336 ENZYME 3.1.3.27 http://enzyme.expasy.org/EC/3.1.3.27 EchoBASE EB1345 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1345 EcoGene EG11371 http://www.ecogene.org/geneInfo.php?eg_id=EG11371 EnsemblBacteria AAC75613 http://www.ensemblgenomes.org/id/AAC75613 EnsemblBacteria AAC75613 http://www.ensemblgenomes.org/id/AAC75613 EnsemblBacteria BAE76736 http://www.ensemblgenomes.org/id/BAE76736 EnsemblBacteria BAE76736 http://www.ensemblgenomes.org/id/BAE76736 EnsemblBacteria BAE76736 http://www.ensemblgenomes.org/id/BAE76736 EnsemblBacteria b2560 http://www.ensemblgenomes.org/id/b2560 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0008962 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008962 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006655 GO_process GO:0009395 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009395 GO_process GO:0046474 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046474 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.1000 http://www.cathdb.info/version/latest/superfamily/3.40.50.1000 GeneID 947026 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947026 HOGENOM HOG000219236 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219236&db=HOGENOM6 IntEnz 3.1.3.27 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.27 InterPro IPR006435 http://www.ebi.ac.uk/interpro/entry/IPR006435 InterPro IPR023214 http://www.ebi.ac.uk/interpro/entry/IPR023214 KEGG_Gene ecj:JW5408 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5408 KEGG_Gene eco:b2560 http://www.genome.jp/dbget-bin/www_bget?eco:b2560 OMA GTFMRYL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GTFMRYL PSORT swissprot:PGPC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PGPC_ECOLI PSORT-B swissprot:PGPC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PGPC_ECOLI PSORT2 swissprot:PGPC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PGPC_ECOLI Phobius swissprot:PGPC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PGPC_ECOLI ProteinModelPortal P0AD42 http://www.proteinmodelportal.org/query/uniprot/P0AD42 PubMed 1602968 http://www.ncbi.nlm.nih.gov/pubmed/1602968 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21148555 http://www.ncbi.nlm.nih.gov/pubmed/21148555 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417055 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417055 RefSeq WP_000190655 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000190655 STRING 511145.b2560 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2560&targetmode=cogs SUPFAM SSF56784 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784 TIGRFAMs TIGR01545 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01545 UniProtKB PGPC_ECOLI http://www.uniprot.org/uniprot/PGPC_ECOLI UniProtKB-AC P0AD42 http://www.uniprot.org/uniprot/P0AD42 charge swissprot:PGPC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PGPC_ECOLI eggNOG COG0560 http://eggnogapi.embl.de/nog_data/html/tree/COG0560 eggNOG ENOG4105HYY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105HYY epestfind swissprot:PGPC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PGPC_ECOLI garnier swissprot:PGPC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PGPC_ECOLI helixturnhelix swissprot:PGPC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PGPC_ECOLI hmoment swissprot:PGPC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PGPC_ECOLI iep swissprot:PGPC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PGPC_ECOLI inforesidue swissprot:PGPC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PGPC_ECOLI octanol swissprot:PGPC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PGPC_ECOLI pepcoil swissprot:PGPC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PGPC_ECOLI pepdigest swissprot:PGPC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PGPC_ECOLI pepinfo swissprot:PGPC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PGPC_ECOLI pepnet swissprot:PGPC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PGPC_ECOLI pepstats swissprot:PGPC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PGPC_ECOLI pepwheel swissprot:PGPC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PGPC_ECOLI pepwindow swissprot:PGPC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PGPC_ECOLI sigcleave swissprot:PGPC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PGPC_ECOLI ## Database ID URL or Descriptions # BioGrid 4261769 13 # EcoGene EG12467 yjdJ # Gene3D 3.40.630.30 -; 1. # IntAct P39274 3 # InterPro IPR016181 Acyl_CoA_acyltransferase # InterPro IPR031165 GNAT_YJDJ # Organism YJDJ_ECOLI Escherichia coli (strain K12) # PATRIC 32123819 VBIEscCol129921_4258 # PDB 5I0C X-ray; 1.92 A; A=1-90 # PIR S56356 S56356 # PROSITE PS51729 GNAT_YJDJ # Pfam PF14542 Acetyltransf_CG # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJDJ_ECOLI Uncharacterized protein YjdJ # RefSeq NP_418551 NC_000913.3 # RefSeq WP_000405651 NZ_LN832404.1 # SIMILARITY Contains 1 N-acetyltransferase domain. {ECO:0000255|PROSITE-ProRule PRU00532}. # SUPFAM SSF55729 SSF55729 # eggNOG COG2388 LUCA # eggNOG ENOG410830R Bacteria BLAST swissprot:YJDJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJDJ_ECOLI BioCyc ECOL316407:JW4088-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4088-MONOMER BioCyc EcoCyc:G7829-MONOMER http://biocyc.org/getid?id=EcoCyc:G7829-MONOMER COG COG2388 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2388 DIP DIP-12566N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12566N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2360 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2360 EcoGene EG12467 http://www.ecogene.org/geneInfo.php?eg_id=EG12467 EnsemblBacteria AAC77088 http://www.ensemblgenomes.org/id/AAC77088 EnsemblBacteria AAC77088 http://www.ensemblgenomes.org/id/AAC77088 EnsemblBacteria BAE78129 http://www.ensemblgenomes.org/id/BAE78129 EnsemblBacteria BAE78129 http://www.ensemblgenomes.org/id/BAE78129 EnsemblBacteria BAE78129 http://www.ensemblgenomes.org/id/BAE78129 EnsemblBacteria b4127 http://www.ensemblgenomes.org/id/b4127 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.40.630.30 http://www.cathdb.info/version/latest/superfamily/3.40.630.30 GeneID 948647 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948647 HOGENOM HOG000167986 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000167986&db=HOGENOM6 InParanoid P39274 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39274 IntAct P39274 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39274* InterPro IPR016181 http://www.ebi.ac.uk/interpro/entry/IPR016181 InterPro IPR031165 http://www.ebi.ac.uk/interpro/entry/IPR031165 KEGG_Gene ecj:JW4088 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4088 KEGG_Gene eco:b4127 http://www.genome.jp/dbget-bin/www_bget?eco:b4127 KEGG_Orthology KO:K06975 http://www.genome.jp/dbget-bin/www_bget?KO:K06975 OMA NRKIIPL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NRKIIPL PDB 5I0C http://www.ebi.ac.uk/pdbe-srv/view/entry/5I0C PDBsum 5I0C http://www.ebi.ac.uk/pdbsum/5I0C PROSITE PS51729 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51729 PSORT swissprot:YJDJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJDJ_ECOLI PSORT-B swissprot:YJDJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJDJ_ECOLI PSORT2 swissprot:YJDJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJDJ_ECOLI Pfam PF14542 http://pfam.xfam.org/family/PF14542 Phobius swissprot:YJDJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJDJ_ECOLI PhylomeDB P39274 http://phylomedb.org/?seqid=P39274 ProteinModelPortal P39274 http://www.proteinmodelportal.org/query/uniprot/P39274 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418551 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418551 RefSeq WP_000405651 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000405651 SMR P39274 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39274 STRING 511145.b4127 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4127&targetmode=cogs STRING COG2388 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2388&targetmode=cogs SUPFAM SSF55729 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55729 UniProtKB YJDJ_ECOLI http://www.uniprot.org/uniprot/YJDJ_ECOLI UniProtKB-AC P39274 http://www.uniprot.org/uniprot/P39274 charge swissprot:YJDJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJDJ_ECOLI eggNOG COG2388 http://eggnogapi.embl.de/nog_data/html/tree/COG2388 eggNOG ENOG410830R http://eggnogapi.embl.de/nog_data/html/tree/ENOG410830R epestfind swissprot:YJDJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJDJ_ECOLI garnier swissprot:YJDJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJDJ_ECOLI helixturnhelix swissprot:YJDJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJDJ_ECOLI hmoment swissprot:YJDJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJDJ_ECOLI iep swissprot:YJDJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJDJ_ECOLI inforesidue swissprot:YJDJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJDJ_ECOLI octanol swissprot:YJDJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJDJ_ECOLI pepcoil swissprot:YJDJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJDJ_ECOLI pepdigest swissprot:YJDJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJDJ_ECOLI pepinfo swissprot:YJDJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJDJ_ECOLI pepnet swissprot:YJDJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJDJ_ECOLI pepstats swissprot:YJDJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJDJ_ECOLI pepwheel swissprot:YJDJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJDJ_ECOLI pepwindow swissprot:YJDJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJDJ_ECOLI sigcleave swissprot:YJDJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJDJ_ECOLI ## Database ID URL or Descriptions # AltName TFAR_ECOLI Tail fiber assembly protein homolog from lambdoid prophage Rac # BioGrid 4263523 91 # EcoGene EG13371 tfaR # InterPro IPR003458 Phage_T4_Gp38_tail_assem # Organism TFAR_ECOLI Escherichia coli (strain K12) # PATRIC 32118028 VBIEscCol129921_1434 # PIR H64887 H64887 # Pfam PF02413 Caudo_TAP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Prophage tail fiber assembly protein homolog TfaR {ECO 0000305} # RefSeq NP_415891 NC_000913.3 # RefSeq WP_001698950 NZ_CP014272.1 # SIMILARITY Belongs to the tfa family. {ECO 0000305}. # eggNOG ENOG4105UZW Bacteria # eggNOG ENOG4111ZCI LUCA BLAST swissprot:TFAR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TFAR_ECOLI BioCyc ECOL316407:JW1367-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1367-MONOMER BioCyc EcoCyc:G6696-MONOMER http://biocyc.org/getid?id=EcoCyc:G6696-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3153 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3153 EcoGene EG13371 http://www.ecogene.org/geneInfo.php?eg_id=EG13371 EnsemblBacteria AAC74455 http://www.ensemblgenomes.org/id/AAC74455 EnsemblBacteria AAC74455 http://www.ensemblgenomes.org/id/AAC74455 EnsemblBacteria BAA14978 http://www.ensemblgenomes.org/id/BAA14978 EnsemblBacteria BAA14978 http://www.ensemblgenomes.org/id/BAA14978 EnsemblBacteria BAA14978 http://www.ensemblgenomes.org/id/BAA14978 EnsemblBacteria b1373 http://www.ensemblgenomes.org/id/b1373 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946062 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946062 HOGENOM HOG000118670 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118670&db=HOGENOM6 InterPro IPR003458 http://www.ebi.ac.uk/interpro/entry/IPR003458 KEGG_Gene ecj:JW1367 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1367 KEGG_Gene eco:b1373 http://www.genome.jp/dbget-bin/www_bget?eco:b1373 OMA MAFIMSE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MAFIMSE PSORT swissprot:TFAR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TFAR_ECOLI PSORT-B swissprot:TFAR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TFAR_ECOLI PSORT2 swissprot:TFAR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TFAR_ECOLI Pfam PF02413 http://pfam.xfam.org/family/PF02413 Phobius swissprot:TFAR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TFAR_ECOLI PhylomeDB P77163 http://phylomedb.org/?seqid=P77163 ProteinModelPortal P77163 http://www.proteinmodelportal.org/query/uniprot/P77163 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415891 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415891 RefSeq WP_001698950 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001698950 STRING 511145.b1373 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1373&targetmode=cogs UniProtKB TFAR_ECOLI http://www.uniprot.org/uniprot/TFAR_ECOLI UniProtKB-AC P77163 http://www.uniprot.org/uniprot/P77163 charge swissprot:TFAR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TFAR_ECOLI eggNOG ENOG4105UZW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105UZW eggNOG ENOG4111ZCI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111ZCI epestfind swissprot:TFAR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TFAR_ECOLI garnier swissprot:TFAR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TFAR_ECOLI helixturnhelix swissprot:TFAR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TFAR_ECOLI hmoment swissprot:TFAR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TFAR_ECOLI iep swissprot:TFAR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TFAR_ECOLI inforesidue swissprot:TFAR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TFAR_ECOLI octanol swissprot:TFAR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TFAR_ECOLI pepcoil swissprot:TFAR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TFAR_ECOLI pepdigest swissprot:TFAR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TFAR_ECOLI pepinfo swissprot:TFAR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TFAR_ECOLI pepnet swissprot:TFAR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TFAR_ECOLI pepstats swissprot:TFAR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TFAR_ECOLI pepwheel swissprot:TFAR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TFAR_ECOLI pepwindow swissprot:TFAR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TFAR_ECOLI sigcleave swissprot:TFAR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TFAR_ECOLI ## Database ID URL or Descriptions # AltName FECE_ECOLI Iron(III) dicitrate transport ATP-binding protein FecE # BioGrid 4262739 249 # EcoGene EG10290 fecE # FUNCTION FECE_ECOLI Part of the binding-protein-dependent transport system for citrate-dependent Fe(3+). Probably responsible for energy coupling to the transport system. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016887 ATPase activity; IEA:InterPro. # GO_process GO:0006811 ion transport; IEA:UniProtKB-KW. # GO_process GO:0055072 iron ion homeostasis; IEA:UniProtKB-KW. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # GOslim_process GO:0042592 homeostatic process # Gene3D 3.40.50.300 -; 1. # INDUCTION Induced 1.6-fold by hydroxyurea. {ECO:0000269|PubMed 20005847}. # IntAct P15031 2 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00240 Iron complex transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism FECE_ECOLI Escherichia coli (strain K12) # PATRIC 32124151 VBIEscCol129921_4419 # PIR JS0115 QRECM3 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # Pfam PF00005 ABC_tran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FECE_ECOLI Fe(3+) dicitrate transport ATP-binding protein FecE # RefSeq NP_418707 NC_000913.3 # RefSeq WP_000175457 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA # SUBCELLULAR LOCATION FECE_ECOLI Cell inner membrane; Peripheral membrane protein. # SUPFAM SSF52540 SSF52540 # TCDB 3.A.1.14 the atp-binding cassette (abc) superfamily # eggNOG COG1120 LUCA # eggNOG ENOG4105E0A Bacteria BLAST swissprot:FECE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FECE_ECOLI BioCyc ECOL316407:JW4247-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4247-MONOMER BioCyc EcoCyc:FECE-MONOMER http://biocyc.org/getid?id=EcoCyc:FECE-MONOMER BioCyc MetaCyc:FECE-MONOMER http://biocyc.org/getid?id=MetaCyc:FECE-MONOMER COG COG1120 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1120 DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M26397 http://www.ebi.ac.uk/ena/data/view/M26397 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB0286 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0286 EcoGene EG10290 http://www.ecogene.org/geneInfo.php?eg_id=EG10290 EnsemblBacteria AAC77243 http://www.ensemblgenomes.org/id/AAC77243 EnsemblBacteria AAC77243 http://www.ensemblgenomes.org/id/AAC77243 EnsemblBacteria BAE78278 http://www.ensemblgenomes.org/id/BAE78278 EnsemblBacteria BAE78278 http://www.ensemblgenomes.org/id/BAE78278 EnsemblBacteria BAE78278 http://www.ensemblgenomes.org/id/BAE78278 EnsemblBacteria b4287 http://www.ensemblgenomes.org/id/b4287 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_process GO:0006811 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811 GO_process GO:0055072 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055072 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948819 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948819 InParanoid P15031 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P15031 IntAct P15031 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P15031* InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW4247 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4247 KEGG_Gene eco:b4287 http://www.genome.jp/dbget-bin/www_bget?eco:b4287 KEGG_Orthology KO:K02013 http://www.genome.jp/dbget-bin/www_bget?KO:K02013 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA AYSSREL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AYSSREL PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:FECE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FECE_ECOLI PSORT-B swissprot:FECE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FECE_ECOLI PSORT2 swissprot:FECE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FECE_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Phobius swissprot:FECE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FECE_ECOLI PhylomeDB P15031 http://phylomedb.org/?seqid=P15031 ProteinModelPortal P15031 http://www.proteinmodelportal.org/query/uniprot/P15031 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 2651410 http://www.ncbi.nlm.nih.gov/pubmed/2651410 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418707 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418707 RefSeq WP_000175457 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000175457 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P15031 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P15031 STRING 511145.b4287 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4287&targetmode=cogs STRING COG1120 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1120&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.14 http://www.tcdb.org/search/result.php?tc=3.A.1.14 UniProtKB FECE_ECOLI http://www.uniprot.org/uniprot/FECE_ECOLI UniProtKB-AC P15031 http://www.uniprot.org/uniprot/P15031 charge swissprot:FECE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FECE_ECOLI eggNOG COG1120 http://eggnogapi.embl.de/nog_data/html/tree/COG1120 eggNOG ENOG4105E0A http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E0A epestfind swissprot:FECE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FECE_ECOLI garnier swissprot:FECE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FECE_ECOLI helixturnhelix swissprot:FECE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FECE_ECOLI hmoment swissprot:FECE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FECE_ECOLI iep swissprot:FECE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FECE_ECOLI inforesidue swissprot:FECE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FECE_ECOLI octanol swissprot:FECE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FECE_ECOLI pepcoil swissprot:FECE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FECE_ECOLI pepdigest swissprot:FECE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FECE_ECOLI pepinfo swissprot:FECE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FECE_ECOLI pepnet swissprot:FECE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FECE_ECOLI pepstats swissprot:FECE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FECE_ECOLI pepwheel swissprot:FECE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FECE_ECOLI pepwindow swissprot:FECE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FECE_ECOLI sigcleave swissprot:FECE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FECE_ECOLI ## Database ID URL or Descriptions # BioGrid 4261619 170 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG13365 ydaW # Gene3D 1.10.10.10 -; 1. # INTERACTION YDAW_ECOLI P61949 fldA; NbExp=2; IntAct=EBI-9142914, EBI-550021; # IntAct P76066 3 # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR012432 DUF1627 # MISCELLANEOUS This protein could be 17 residues longer at the N- terminus, but this makes a 9 residue overlap with upstream protein YdaV and consequently the longer version has not been annotated. {ECO 0000305}. # Organism YDAW_ECOLI Escherichia coli (strain K12) # PATRIC 48662015 VBIEscCol107702_1371 # PIR D64886 D64886 # Pfam PF07789 DUF1627 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDAW_ECOLI Putative uncharacterized protein YdaW # SUPFAM SSF46785 SSF46785 BLAST swissprot:YDAW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDAW_ECOLI BioCyc ECOL316407:JW5211-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5211-MONOMER BioCyc EcoCyc:G6685-MONOMER http://biocyc.org/getid?id=EcoCyc:G6685-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3148 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3148 EcoGene EG13365 http://www.ecogene.org/geneInfo.php?eg_id=EG13365 EnsemblBacteria BAE76415 http://www.ensemblgenomes.org/id/BAE76415 EnsemblBacteria BAE76415 http://www.ensemblgenomes.org/id/BAE76415 EnsemblBacteria BAE76415 http://www.ensemblgenomes.org/id/BAE76415 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 HOGENOM HOG000120231 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120231&db=HOGENOM6 IntAct P76066 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76066* InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR012432 http://www.ebi.ac.uk/interpro/entry/IPR012432 KEGG_Gene ecj:JW5211 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5211 OMA KNSATKM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KNSATKM PSORT swissprot:YDAW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDAW_ECOLI PSORT-B swissprot:YDAW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDAW_ECOLI PSORT2 swissprot:YDAW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDAW_ECOLI Pfam PF07789 http://pfam.xfam.org/family/PF07789 Phobius swissprot:YDAW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDAW_ECOLI ProteinModelPortal P76066 http://www.proteinmodelportal.org/query/uniprot/P76066 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SMR P76066 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76066 STRING 316407.85674925 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85674925&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB YDAW_ECOLI http://www.uniprot.org/uniprot/YDAW_ECOLI UniProtKB-AC P76066 http://www.uniprot.org/uniprot/P76066 charge swissprot:YDAW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDAW_ECOLI epestfind swissprot:YDAW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDAW_ECOLI garnier swissprot:YDAW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDAW_ECOLI helixturnhelix swissprot:YDAW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDAW_ECOLI hmoment swissprot:YDAW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDAW_ECOLI iep swissprot:YDAW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDAW_ECOLI inforesidue swissprot:YDAW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDAW_ECOLI octanol swissprot:YDAW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDAW_ECOLI pepcoil swissprot:YDAW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDAW_ECOLI pepdigest swissprot:YDAW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDAW_ECOLI pepinfo swissprot:YDAW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDAW_ECOLI pepnet swissprot:YDAW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDAW_ECOLI pepstats swissprot:YDAW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDAW_ECOLI pepwheel swissprot:YDAW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDAW_ECOLI pepwindow swissprot:YDAW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDAW_ECOLI sigcleave swissprot:YDAW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDAW_ECOLI ## Database ID URL or Descriptions # BioGrid 4262725 156 # CATALYTIC ACTIVITY HOLC_ECOLI Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). # EcoGene EG11413 holC # FUNCTION HOLC_ECOLI DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. # GO_component GO:0043847 DNA polymerase III, clamp loader chi/psi subcomplex; IPI:EcoliWiki. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_function GO:0003887 DNA-directed DNA polymerase activity; IEA:UniProtKB-KW. # GO_process GO:0006260 DNA replication; IEA:UniProtKB-KW. # GO_process GO:0032298 positive regulation of DNA-dependent DNA replication initiation; IDA:EcoliWiki. # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.10110 -; 1. # INTERACTION HOLC_ECOLI P06710 dnaX; NbExp=13; IntAct=EBI-549169, EBI-549140; P28631 holB; NbExp=5; IntAct=EBI-549169, EBI-549161; P28632 holD; NbExp=22; IntAct=EBI-549169, EBI-549176; P0AGE0 ssb; NbExp=9; IntAct=EBI-549169, EBI-1118620; # IntAct P28905 41 # InterPro IPR007459 DNA_pol3_chi # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03032 DNA replication proteins # KEGG_Brite ko03032 M00260 DNA polymerase III complex, bacteria # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Brite ko03400 M00260 DNA polymerase III complex, bacteria # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00240 Pyrimidine metabolism # KEGG_Pathway ko03030 DNA replication # KEGG_Pathway ko03430 Mismatch repair # KEGG_Pathway ko03440 Homologous recombination # Organism HOLC_ECOLI Escherichia coli (strain K12) # PATRIC 32124089 VBIEscCol129921_4389 # PDB 1EM8 X-ray; 2.10 A; A/C=1-147 # PDB 3SXU X-ray; 1.85 A; A=1-147 # PIR A46739 A46739 # Pfam PF04364 DNA_pol3_chi # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HOLC_ECOLI DNA polymerase III subunit chi # RefSeq NP_418680 NC_000913.3 # RefSeq WP_000786400 NZ_LN832404.1 # SUBUNIT The DNA polymerase holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential subassemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core (subunits alpha,epsilon and theta) contains the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork. This complex contains delta, delta', psi and chi, and copies of either or both of two different DnaX proteins, gamma and tau. The composition of the holoenzyme is, therefore (alpha,epsilon,theta)[2]-(gamma/tau)[3]-delta,delta', psi,chi- beta[4]. # SUPFAM SSF102400 SSF102400 # eggNOG COG2927 LUCA # eggNOG ENOG4105MYG Bacteria BLAST swissprot:HOLC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HOLC_ECOLI BioCyc ECOL316407:JW4216-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4216-MONOMER BioCyc EcoCyc:EG11413-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11413-MONOMER BioCyc MetaCyc:EG11413-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11413-MONOMER COG COG2927 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2927 DIP DIP-9933N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9933N DOI 10.1002/bies.950140206 http://dx.doi.org/10.1002/bies.950140206 DOI 10.1007/BF00284693 http://dx.doi.org/10.1007/BF00284693 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.7.7 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.7 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L04574 http://www.ebi.ac.uk/ena/data/view/L04574 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X15130 http://www.ebi.ac.uk/ena/data/view/X15130 EMBL Z14155 http://www.ebi.ac.uk/ena/data/view/Z14155 ENZYME 2.7.7.7 http://enzyme.expasy.org/EC/2.7.7.7 EchoBASE EB1385 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1385 EcoGene EG11413 http://www.ecogene.org/geneInfo.php?eg_id=EG11413 EnsemblBacteria AAC77216 http://www.ensemblgenomes.org/id/AAC77216 EnsemblBacteria AAC77216 http://www.ensemblgenomes.org/id/AAC77216 EnsemblBacteria BAE78256 http://www.ensemblgenomes.org/id/BAE78256 EnsemblBacteria BAE78256 http://www.ensemblgenomes.org/id/BAE78256 EnsemblBacteria BAE78256 http://www.ensemblgenomes.org/id/BAE78256 EnsemblBacteria b4259 http://www.ensemblgenomes.org/id/b4259 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0043847 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043847 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003887 GO_process GO:0006260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260 GO_process GO:0032298 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032298 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.10110 http://www.cathdb.info/version/latest/superfamily/3.40.50.10110 GeneID 948787 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948787 HOGENOM HOG000263567 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000263567&db=HOGENOM6 InParanoid P28905 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P28905 IntAct P28905 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P28905* IntEnz 2.7.7.7 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.7 InterPro IPR007459 http://www.ebi.ac.uk/interpro/entry/IPR007459 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03032 http://www.genome.jp/dbget-bin/www_bget?ko03032 KEGG_Brite ko03032 http://www.genome.jp/dbget-bin/www_bget?ko03032 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW4216 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4216 KEGG_Gene eco:b4259 http://www.genome.jp/dbget-bin/www_bget?eco:b4259 KEGG_Orthology KO:K02339 http://www.genome.jp/dbget-bin/www_bget?KO:K02339 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Pathway ko03030 http://www.genome.jp/kegg-bin/show_pathway?ko03030 KEGG_Pathway ko03430 http://www.genome.jp/kegg-bin/show_pathway?ko03430 KEGG_Pathway ko03440 http://www.genome.jp/kegg-bin/show_pathway?ko03440 KEGG_Reaction rn:R00375 http://www.genome.jp/dbget-bin/www_bget?rn:R00375 KEGG_Reaction rn:R00376 http://www.genome.jp/dbget-bin/www_bget?rn:R00376 KEGG_Reaction rn:R00377 http://www.genome.jp/dbget-bin/www_bget?rn:R00377 KEGG_Reaction rn:R00378 http://www.genome.jp/dbget-bin/www_bget?rn:R00378 MINT MINT-1224072 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1224072 OMA WQFEPSA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WQFEPSA PDB 1EM8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1EM8 PDB 3SXU http://www.ebi.ac.uk/pdbe-srv/view/entry/3SXU PDBsum 1EM8 http://www.ebi.ac.uk/pdbsum/1EM8 PDBsum 3SXU http://www.ebi.ac.uk/pdbsum/3SXU PSORT swissprot:HOLC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HOLC_ECOLI PSORT-B swissprot:HOLC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HOLC_ECOLI PSORT2 swissprot:HOLC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HOLC_ECOLI Pfam PF04364 http://pfam.xfam.org/family/PF04364 Phobius swissprot:HOLC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HOLC_ECOLI ProteinModelPortal P28905 http://www.proteinmodelportal.org/query/uniprot/P28905 PubMed 1575709 http://www.ncbi.nlm.nih.gov/pubmed/1575709 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2670557 http://www.ncbi.nlm.nih.gov/pubmed/2670557 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8246893 http://www.ncbi.nlm.nih.gov/pubmed/8246893 PubMed 8389364 http://www.ncbi.nlm.nih.gov/pubmed/8389364 PubMed 8505305 http://www.ncbi.nlm.nih.gov/pubmed/8505305 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418680 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418680 RefSeq WP_000786400 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000786400 SMR P28905 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P28905 STRING 511145.b4259 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4259&targetmode=cogs STRING COG2927 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2927&targetmode=cogs SUPFAM SSF102400 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF102400 UniProtKB HOLC_ECOLI http://www.uniprot.org/uniprot/HOLC_ECOLI UniProtKB-AC P28905 http://www.uniprot.org/uniprot/P28905 charge swissprot:HOLC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HOLC_ECOLI eggNOG COG2927 http://eggnogapi.embl.de/nog_data/html/tree/COG2927 eggNOG ENOG4105MYG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105MYG epestfind swissprot:HOLC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HOLC_ECOLI garnier swissprot:HOLC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HOLC_ECOLI helixturnhelix swissprot:HOLC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HOLC_ECOLI hmoment swissprot:HOLC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HOLC_ECOLI iep swissprot:HOLC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HOLC_ECOLI inforesidue swissprot:HOLC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HOLC_ECOLI octanol swissprot:HOLC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HOLC_ECOLI pepcoil swissprot:HOLC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HOLC_ECOLI pepdigest swissprot:HOLC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HOLC_ECOLI pepinfo swissprot:HOLC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HOLC_ECOLI pepnet swissprot:HOLC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HOLC_ECOLI pepstats swissprot:HOLC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HOLC_ECOLI pepwheel swissprot:HOLC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HOLC_ECOLI pepwindow swissprot:HOLC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HOLC_ECOLI sigcleave swissprot:HOLC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HOLC_ECOLI ## Database ID URL or Descriptions # AltName PUR5_ECOLI AIR synthase # AltName PUR5_ECOLI AIRS # AltName PUR5_ECOLI Phosphoribosyl-aminoimidazole synthetase # BRENDA 6.3.3 2026 # BioGrid 4261439 18 # CATALYTIC ACTIVITY PUR5_ECOLI ATP + 2-(formamido)-N(1)-(5-phospho-D- ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D- ribosyl)imidazole. # CDD cd02196 PurM # EcoGene EG10798 purM # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004641 phosphoribosylformylglycinamidine cyclo-ligase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0006189 'de novo' IMP biosynthetic process; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.30.1330.10 -; 1. # Gene3D 3.90.650.10 -; 1. # HAMAP MF_00741 AIRS # IntAct P08178 4 # InterPro IPR004733 PurM_cligase # InterPro IPR010918 AIR_synth_C_dom # InterPro IPR016188 PurM-like_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # Organism PUR5_ECOLI Escherichia coli (strain K12) # PATHWAY Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5- phospho-D-ribosyl)glycinamide step 2/2. # PATRIC 32120387 VBIEscCol129921_2596 # PDB 1CLI X-ray; 2.50 A; A/B/C/D=2-345 # PIR A25955 AJECPC # Pfam PF00586 AIRS # Pfam PF02769 AIRS_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PUR5_ECOLI Phosphoribosylformylglycinamidine cyclo-ligase # RefSeq NP_416994 NC_000913.3 # RefSeq WP_001336050 NZ_LN832404.1 # SIMILARITY Belongs to the AIR synthase family. {ECO 0000305}. # SUBCELLULAR LOCATION PUR5_ECOLI Cytoplasm. # SUBUNIT PUR5_ECOLI Homodimer. # SUPFAM SSF56042 SSF56042 # TIGRFAMs TIGR00878 purM # UniPathway UPA00074 UER00129 # eggNOG COG0150 LUCA # eggNOG ENOG4105CXB Bacteria BLAST swissprot:PUR5_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PUR5_ECOLI BioCyc ECOL316407:JW2484-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2484-MONOMER BioCyc EcoCyc:AIRS-MONOMER http://biocyc.org/getid?id=EcoCyc:AIRS-MONOMER BioCyc MetaCyc:AIRS-MONOMER http://biocyc.org/getid?id=MetaCyc:AIRS-MONOMER COG COG0150 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0150 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1016/S0969-2126(99)80182-8 http://dx.doi.org/10.1016/S0969-2126(99)80182-8 DOI 10.1021/bi00363a028 http://dx.doi.org/10.1021/bi00363a028 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.3.3.1 http://www.genome.jp/dbget-bin/www_bget?EC:6.3.3.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M13747 http://www.ebi.ac.uk/ena/data/view/M13747 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 6.3.3.1 http://enzyme.expasy.org/EC/6.3.3.1 EchoBASE EB0791 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0791 EcoGene EG10798 http://www.ecogene.org/geneInfo.php?eg_id=EG10798 EnsemblBacteria AAC75552 http://www.ensemblgenomes.org/id/AAC75552 EnsemblBacteria AAC75552 http://www.ensemblgenomes.org/id/AAC75552 EnsemblBacteria BAA16387 http://www.ensemblgenomes.org/id/BAA16387 EnsemblBacteria BAA16387 http://www.ensemblgenomes.org/id/BAA16387 EnsemblBacteria BAA16387 http://www.ensemblgenomes.org/id/BAA16387 EnsemblBacteria b2499 http://www.ensemblgenomes.org/id/b2499 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004641 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006189 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006189 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.30.1330.10 http://www.cathdb.info/version/latest/superfamily/3.30.1330.10 Gene3D 3.90.650.10 http://www.cathdb.info/version/latest/superfamily/3.90.650.10 GeneID 946975 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946975 HAMAP MF_00741 http://hamap.expasy.org/unirule/MF_00741 HOGENOM HOG000229091 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000229091&db=HOGENOM6 InParanoid P08178 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P08178 IntAct P08178 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P08178* IntEnz 6.3.3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.3.1 InterPro IPR004733 http://www.ebi.ac.uk/interpro/entry/IPR004733 InterPro IPR010918 http://www.ebi.ac.uk/interpro/entry/IPR010918 InterPro IPR016188 http://www.ebi.ac.uk/interpro/entry/IPR016188 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2484 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2484 KEGG_Gene eco:b2499 http://www.genome.jp/dbget-bin/www_bget?eco:b2499 KEGG_Orthology KO:K01933 http://www.genome.jp/dbget-bin/www_bget?KO:K01933 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Reaction rn:R04208 http://www.genome.jp/dbget-bin/www_bget?rn:R04208 OMA LNRHDTV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LNRHDTV PDB 1CLI http://www.ebi.ac.uk/pdbe-srv/view/entry/1CLI PDBsum 1CLI http://www.ebi.ac.uk/pdbsum/1CLI PSORT swissprot:PUR5_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PUR5_ECOLI PSORT-B swissprot:PUR5_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PUR5_ECOLI PSORT2 swissprot:PUR5_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PUR5_ECOLI Pfam PF00586 http://pfam.xfam.org/family/PF00586 Pfam PF02769 http://pfam.xfam.org/family/PF02769 Phobius swissprot:PUR5_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PUR5_ECOLI PhylomeDB P08178 http://phylomedb.org/?seqid=P08178 ProteinModelPortal P08178 http://www.proteinmodelportal.org/query/uniprot/P08178 PubMed 10508786 http://www.ncbi.nlm.nih.gov/pubmed/10508786 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3015935 http://www.ncbi.nlm.nih.gov/pubmed/3015935 PubMed 3530323 http://www.ncbi.nlm.nih.gov/pubmed/3530323 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_416994 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416994 RefSeq WP_001336050 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001336050 SMR P08178 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P08178 STRING 511145.b2499 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2499&targetmode=cogs STRING COG0150 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0150&targetmode=cogs SUPFAM SSF56042 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56042 TIGRFAMs TIGR00878 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00878 UniProtKB PUR5_ECOLI http://www.uniprot.org/uniprot/PUR5_ECOLI UniProtKB-AC P08178 http://www.uniprot.org/uniprot/P08178 charge swissprot:PUR5_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PUR5_ECOLI eggNOG COG0150 http://eggnogapi.embl.de/nog_data/html/tree/COG0150 eggNOG ENOG4105CXB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CXB epestfind swissprot:PUR5_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PUR5_ECOLI garnier swissprot:PUR5_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PUR5_ECOLI helixturnhelix swissprot:PUR5_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PUR5_ECOLI hmoment swissprot:PUR5_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PUR5_ECOLI iep swissprot:PUR5_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PUR5_ECOLI inforesidue swissprot:PUR5_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PUR5_ECOLI octanol swissprot:PUR5_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PUR5_ECOLI pepcoil swissprot:PUR5_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PUR5_ECOLI pepdigest swissprot:PUR5_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PUR5_ECOLI pepinfo swissprot:PUR5_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PUR5_ECOLI pepnet swissprot:PUR5_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PUR5_ECOLI pepstats swissprot:PUR5_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PUR5_ECOLI pepwheel swissprot:PUR5_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PUR5_ECOLI pepwindow swissprot:PUR5_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PUR5_ECOLI sigcleave swissprot:PUR5_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PUR5_ECOLI ## Database ID URL or Descriptions # AltName LPOA_ECOLI Lipoprotein activator of PBP from the outer membrane A # BioGrid 4261989 55 # DISRUPTION PHENOTYPE Absence of both LpoA and LpoB leads to a decrease in peptide cross-linking and to cell lysis. {ECO:0000269|PubMed 21183074}. # EcoGene EG12778 lpoA # FUNCTION LPOA_ECOLI Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a). Stimulates transpeptidase activity of PBP1a in vitro. {ECO 0000269|PubMed 21183073, ECO 0000269|PubMed 21183074}. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_component GO:0031241 periplasmic side of cell outer membrane; IDA:UniProtKB. # GO_component GO:0042597 periplasmic space; IEA:InterPro. # GO_function GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro. # GO_function GO:0030234 enzyme regulator activity; IDA:UniProtKB. # GO_process GO:0008360 regulation of cell shape; IEA:UniProtKB-KW. # GO_process GO:0009252 peptidoglycan biosynthetic process; IDA:UniProtKB. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_function GO:0030234 enzyme regulator activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # Gene3D 1.25.40.10 -; 1. # HAMAP MF_01890 LpoA # INTERACTION LPOA_ECOLI P02918 mrcA; NbExp=4; IntAct=EBI-557795, EBI-1126191; # IntAct P45464 4 # InterPro IPR007443 LpoA # InterPro IPR011990 TPR-like_helical_dom # InterPro IPR016026 Lytic_TGlyclase_suprhlx_U/L # InterPro IPR028082 Peripla_BP_I # Organism LPOA_ECOLI Escherichia coli (strain K12) # PATRIC 32121712 VBIEscCol129921_3242 # PDB 2MHK NMR; -; A=28-256 # PIR G65104 G65104 # Pfam PF04348 LppC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LPOA_ECOLI Penicillin-binding protein activator LpoA # RefSeq NP_417616 NC_000913.3 # RefSeq WP_000249104 NZ_LN832404.1 # SIMILARITY Belongs to the LpoA family. {ECO 0000305}. # SUBCELLULAR LOCATION LPOA_ECOLI Cell outer membrane {ECO 0000269|PubMed 21183073, ECO 0000269|PubMed 21183074}; Lipid- anchor {ECO 0000269|PubMed 21183073, ECO 0000269|PubMed 21183074}; Periplasmic side {ECO 0000269|PubMed 21183073, ECO 0000269|PubMed 21183074}. Note=Localizes at the sidewall of elongating cells. # SUBUNIT LPOA_ECOLI Interacts with PBP1a. {ECO 0000269|PubMed 21183073, ECO 0000269|PubMed 21183074}. # SUPFAM SSF48435 SSF48435 # SUPFAM SSF53822 SSF53822; 3 # eggNOG COG3107 LUCA # eggNOG ENOG4105E1C Bacteria BLAST swissprot:LPOA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LPOA_ECOLI BioCyc ECOL316407:JW3116-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3116-MONOMER BioCyc EcoCyc:G7642-MONOMER http://biocyc.org/getid?id=EcoCyc:G7642-MONOMER BioCyc MetaCyc:G7642-MONOMER http://biocyc.org/getid?id=MetaCyc:G7642-MONOMER COG COG3107 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3107 DIP DIP-12897N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12897N DOI 10.1016/j.cell.2010.11.037 http://dx.doi.org/10.1016/j.cell.2010.11.037 DOI 10.1016/j.cell.2010.11.038 http://dx.doi.org/10.1016/j.cell.2010.11.038 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2631 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2631 EcoGene EG12778 http://www.ecogene.org/geneInfo.php?eg_id=EG12778 EnsemblBacteria AAC76181 http://www.ensemblgenomes.org/id/AAC76181 EnsemblBacteria AAC76181 http://www.ensemblgenomes.org/id/AAC76181 EnsemblBacteria BAE77193 http://www.ensemblgenomes.org/id/BAE77193 EnsemblBacteria BAE77193 http://www.ensemblgenomes.org/id/BAE77193 EnsemblBacteria BAE77193 http://www.ensemblgenomes.org/id/BAE77193 EnsemblBacteria b3147 http://www.ensemblgenomes.org/id/b3147 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0031241 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031241 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0004553 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004553 GO_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0009252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009252 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 1.25.40.10 http://www.cathdb.info/version/latest/superfamily/1.25.40.10 GeneID 947663 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947663 HAMAP MF_01890 http://hamap.expasy.org/unirule/MF_01890 HOGENOM HOG000125217 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125217&db=HOGENOM6 InParanoid P45464 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45464 IntAct P45464 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45464* InterPro IPR007443 http://www.ebi.ac.uk/interpro/entry/IPR007443 InterPro IPR011990 http://www.ebi.ac.uk/interpro/entry/IPR011990 InterPro IPR016026 http://www.ebi.ac.uk/interpro/entry/IPR016026 InterPro IPR028082 http://www.ebi.ac.uk/interpro/entry/IPR028082 KEGG_Gene ecj:JW3116 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3116 KEGG_Gene eco:b3147 http://www.genome.jp/dbget-bin/www_bget?eco:b3147 KEGG_Orthology KO:K07121 http://www.genome.jp/dbget-bin/www_bget?KO:K07121 MINT MINT-1258091 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1258091 OMA FCETPWL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FCETPWL PDB 2MHK http://www.ebi.ac.uk/pdbe-srv/view/entry/2MHK PDBsum 2MHK http://www.ebi.ac.uk/pdbsum/2MHK PSORT swissprot:LPOA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LPOA_ECOLI PSORT-B swissprot:LPOA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LPOA_ECOLI PSORT2 swissprot:LPOA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LPOA_ECOLI Pfam PF04348 http://pfam.xfam.org/family/PF04348 Phobius swissprot:LPOA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LPOA_ECOLI ProteinModelPortal P45464 http://www.proteinmodelportal.org/query/uniprot/P45464 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21183073 http://www.ncbi.nlm.nih.gov/pubmed/21183073 PubMed 21183074 http://www.ncbi.nlm.nih.gov/pubmed/21183074 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417616 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417616 RefSeq WP_000249104 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000249104 SMR P45464 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45464 STRING 511145.b3147 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3147&targetmode=cogs STRING COG3107 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3107&targetmode=cogs SUPFAM SSF48435 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48435 SUPFAM SSF53822 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822 UniProtKB LPOA_ECOLI http://www.uniprot.org/uniprot/LPOA_ECOLI UniProtKB-AC P45464 http://www.uniprot.org/uniprot/P45464 charge swissprot:LPOA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LPOA_ECOLI eggNOG COG3107 http://eggnogapi.embl.de/nog_data/html/tree/COG3107 eggNOG ENOG4105E1C http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E1C epestfind swissprot:LPOA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LPOA_ECOLI garnier swissprot:LPOA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LPOA_ECOLI helixturnhelix swissprot:LPOA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LPOA_ECOLI hmoment swissprot:LPOA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LPOA_ECOLI iep swissprot:LPOA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LPOA_ECOLI inforesidue swissprot:LPOA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LPOA_ECOLI octanol swissprot:LPOA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LPOA_ECOLI pepcoil swissprot:LPOA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LPOA_ECOLI pepdigest swissprot:LPOA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LPOA_ECOLI pepinfo swissprot:LPOA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LPOA_ECOLI pepnet swissprot:LPOA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LPOA_ECOLI pepstats swissprot:LPOA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LPOA_ECOLI pepwheel swissprot:LPOA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LPOA_ECOLI pepwindow swissprot:LPOA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LPOA_ECOLI sigcleave swissprot:LPOA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LPOA_ECOLI ## Database ID URL or Descriptions # AltName PMBA_ECOLI Protein TldE # BioGrid 4262248 11 # EcoGene EG10741 pmbA # FUNCTION PMBA_ECOLI Metalloprotease involved in CcdA degradation. Suppresses the inhibitory activity of the carbon storage regulator (CsrA). {ECO 0000269|PubMed 12029038}. # GO_component GO:0005737 cytoplasm; IDA:EcoCyc. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008237 metallopeptidase activity; IBA:GO_Central. # GO_function GO:0008270 zinc ion binding; IBA:GO_Central. # GO_process GO:0006508 proteolysis; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # IntAct P0AFK0 6 # InterPro IPR002510 TldD/PmbA # KEGG_Brite ko01002 Peptidases # MISCELLANEOUS In strains containing the pMccB17 plasmid, required for the maturation and secretion of the antibiotic bacteriocin microcin B17 (MccB17). {ECO:0000305|PubMed 12029038}. # Organism PMBA_ECOLI Escherichia coli (strain K12) # PATRIC 32124043 VBIEscCol129921_4366 # PIR S13730 S13730 # Pfam PF01523 PmbA_TldD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PMBA_ECOLI Metalloprotease PmbA # RefSeq NP_418656 NC_000913.3 # RefSeq WP_001162171 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase U62 family. {ECO 0000305}. # SUBCELLULAR LOCATION PMBA_ECOLI Cytoplasm. # eggNOG COG0312 LUCA # eggNOG ENOG4105CMS Bacteria BLAST swissprot:PMBA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PMBA_ECOLI BioCyc ECOL316407:JW4194-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4194-MONOMER BioCyc EcoCyc:EG10741-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10741-MONOMER COG COG0312 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0312 DIP DIP-47844N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47844N DOI 10.1006/jmbi.1996.0103 http://dx.doi.org/10.1006/jmbi.1996.0103 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1111/j.1365-2958.1990.tb02041.x http://dx.doi.org/10.1111/j.1365-2958.1990.tb02041.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.12.3224-3231.2002 http://dx.doi.org/10.1128/JB.184.12.3224-3231.2002 EC_number EC:3.4.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.4.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D44452 http://www.ebi.ac.uk/ena/data/view/D44452 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X54152 http://www.ebi.ac.uk/ena/data/view/X54152 ENZYME 3.4.-.- http://enzyme.expasy.org/EC/3.4.-.- EchoBASE EB0734 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0734 EcoGene EG10741 http://www.ecogene.org/geneInfo.php?eg_id=EG10741 EnsemblBacteria AAC77192 http://www.ensemblgenomes.org/id/AAC77192 EnsemblBacteria AAC77192 http://www.ensemblgenomes.org/id/AAC77192 EnsemblBacteria BAE78235 http://www.ensemblgenomes.org/id/BAE78235 EnsemblBacteria BAE78235 http://www.ensemblgenomes.org/id/BAE78235 EnsemblBacteria BAE78235 http://www.ensemblgenomes.org/id/BAE78235 EnsemblBacteria b4235 http://www.ensemblgenomes.org/id/b4235 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008237 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008237 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_process GO:0006508 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006508 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 948750 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948750 HOGENOM HOG000224928 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000224928&db=HOGENOM6 InParanoid P0AFK0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFK0 IntAct P0AFK0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFK0* IntEnz 3.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4 InterPro IPR002510 http://www.ebi.ac.uk/interpro/entry/IPR002510 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW4194 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4194 KEGG_Gene eco:b4235 http://www.genome.jp/dbget-bin/www_bget?eco:b4235 KEGG_Orthology KO:K03592 http://www.genome.jp/dbget-bin/www_bget?KO:K03592 OMA ETVEFNK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ETVEFNK PSORT swissprot:PMBA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PMBA_ECOLI PSORT-B swissprot:PMBA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PMBA_ECOLI PSORT2 swissprot:PMBA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PMBA_ECOLI Pfam PF01523 http://pfam.xfam.org/family/PF01523 Phobius swissprot:PMBA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PMBA_ECOLI PhylomeDB P0AFK0 http://phylomedb.org/?seqid=P0AFK0 ProteinModelPortal P0AFK0 http://www.proteinmodelportal.org/query/uniprot/P0AFK0 PubMed 12029038 http://www.ncbi.nlm.nih.gov/pubmed/12029038 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2082149 http://www.ncbi.nlm.nih.gov/pubmed/2082149 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8604133 http://www.ncbi.nlm.nih.gov/pubmed/8604133 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418656 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418656 RefSeq WP_001162171 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001162171 SMR P0AFK0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFK0 STRING 511145.b4235 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4235&targetmode=cogs STRING COG0312 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0312&targetmode=cogs UniProtKB PMBA_ECOLI http://www.uniprot.org/uniprot/PMBA_ECOLI UniProtKB-AC P0AFK0 http://www.uniprot.org/uniprot/P0AFK0 charge swissprot:PMBA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PMBA_ECOLI eggNOG COG0312 http://eggnogapi.embl.de/nog_data/html/tree/COG0312 eggNOG ENOG4105CMS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CMS epestfind swissprot:PMBA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PMBA_ECOLI garnier swissprot:PMBA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PMBA_ECOLI helixturnhelix swissprot:PMBA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PMBA_ECOLI hmoment swissprot:PMBA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PMBA_ECOLI iep swissprot:PMBA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PMBA_ECOLI inforesidue swissprot:PMBA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PMBA_ECOLI octanol swissprot:PMBA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PMBA_ECOLI pepcoil swissprot:PMBA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PMBA_ECOLI pepdigest swissprot:PMBA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PMBA_ECOLI pepinfo swissprot:PMBA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PMBA_ECOLI pepnet swissprot:PMBA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PMBA_ECOLI pepstats swissprot:PMBA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PMBA_ECOLI pepwheel swissprot:PMBA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PMBA_ECOLI pepwindow swissprot:PMBA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PMBA_ECOLI sigcleave swissprot:PMBA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PMBA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259994 13 # EcoGene EG11629 potF # FUNCTION POTF_ECOLI Required for the activity of the bacterial periplasmic transport system of putrescine. Polyamine binding protein. {ECO 0000269|PubMed 8416922}. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0015594 putrescine-importing ATPase activity; IMP:EcoCyc. # GO_function GO:0019808 polyamine binding; IEA:InterPro. # GO_process GO:0015847 putrescine transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # IntAct P31133 2 # InterPro IPR001188 Sperm_putr-bd # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00300 Putrescine transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism POTF_ECOLI Escherichia coli (strain K12) # PATRIC 32116913 VBIEscCol129921_0882 # PDB 1A99 X-ray; 2.20 A; A/B/C/D=27-370 # PDB 4JDF X-ray; 1.69 A; A=27-370 # PIR F64823 F64823 # PIRSF PIRSF019574 Periplasmic_polyamine_BP # PRINTS PR00909 SPERMDNBNDNG # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName POTF_ECOLI Putrescine-binding periplasmic protein # RefSeq NP_415375 NC_000913.3 # RefSeq WP_000126072 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial solute-binding protein PotD/PotF family. {ECO 0000305}. # SUBCELLULAR LOCATION POTF_ECOLI Periplasm {ECO 0000269|PubMed 8416922}. # TCDB 3.A.1.11 the atp-binding cassette (abc) superfamily # eggNOG COG0687 LUCA # eggNOG ENOG4107RUE Bacteria BLAST swissprot:POTF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:POTF_ECOLI BioCyc ECOL316407:JW0838-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0838-MONOMER BioCyc EcoCyc:POTF-MONOMER http://biocyc.org/getid?id=EcoCyc:POTF-MONOMER BioCyc MetaCyc:POTF-MONOMER http://biocyc.org/getid?id=MetaCyc:POTF-MONOMER COG COG0687 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0687 DIP DIP-10531N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10531N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.273.28.17604 http://dx.doi.org/10.1074/jbc.273.28.17604 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1107/S0907444997009049 http://dx.doi.org/10.1107/S0907444997009049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M93239 http://www.ebi.ac.uk/ena/data/view/M93239 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1586 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1586 EcoGene EG11629 http://www.ecogene.org/geneInfo.php?eg_id=EG11629 EnsemblBacteria AAC73941 http://www.ensemblgenomes.org/id/AAC73941 EnsemblBacteria AAC73941 http://www.ensemblgenomes.org/id/AAC73941 EnsemblBacteria BAA35565 http://www.ensemblgenomes.org/id/BAA35565 EnsemblBacteria BAA35565 http://www.ensemblgenomes.org/id/BAA35565 EnsemblBacteria BAA35565 http://www.ensemblgenomes.org/id/BAA35565 EnsemblBacteria b0854 http://www.ensemblgenomes.org/id/b0854 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0015594 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015594 GO_function GO:0019808 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019808 GO_process GO:0015847 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015847 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 945480 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945480 HOGENOM HOG000263815 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000263815&db=HOGENOM6 InParanoid P31133 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31133 IntAct P31133 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31133* InterPro IPR001188 http://www.ebi.ac.uk/interpro/entry/IPR001188 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0838 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0838 KEGG_Gene eco:b0854 http://www.genome.jp/dbget-bin/www_bget?eco:b0854 KEGG_Orthology KO:K11073 http://www.genome.jp/dbget-bin/www_bget?KO:K11073 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA VEYYIPK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VEYYIPK PDB 1A99 http://www.ebi.ac.uk/pdbe-srv/view/entry/1A99 PDB 4JDF http://www.ebi.ac.uk/pdbe-srv/view/entry/4JDF PDBsum 1A99 http://www.ebi.ac.uk/pdbsum/1A99 PDBsum 4JDF http://www.ebi.ac.uk/pdbsum/4JDF PRINTS PR00909 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00909 PSORT swissprot:POTF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:POTF_ECOLI PSORT-B swissprot:POTF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:POTF_ECOLI PSORT2 swissprot:POTF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:POTF_ECOLI Phobius swissprot:POTF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:POTF_ECOLI PhylomeDB P31133 http://phylomedb.org/?seqid=P31133 ProteinModelPortal P31133 http://www.proteinmodelportal.org/query/uniprot/P31133 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8416922 http://www.ncbi.nlm.nih.gov/pubmed/8416922 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9651355 http://www.ncbi.nlm.nih.gov/pubmed/9651355 PubMed 9761835 http://www.ncbi.nlm.nih.gov/pubmed/9761835 RefSeq NP_415375 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415375 RefSeq WP_000126072 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000126072 SMR P31133 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31133 STRING 511145.b0854 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0854&targetmode=cogs STRING COG0687 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0687&targetmode=cogs SWISS-2DPAGE P31133 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P31133 TCDB 3.A.1.11 http://www.tcdb.org/search/result.php?tc=3.A.1.11 UniProtKB POTF_ECOLI http://www.uniprot.org/uniprot/POTF_ECOLI UniProtKB-AC P31133 http://www.uniprot.org/uniprot/P31133 charge swissprot:POTF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:POTF_ECOLI eggNOG COG0687 http://eggnogapi.embl.de/nog_data/html/tree/COG0687 eggNOG ENOG4107RUE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107RUE epestfind swissprot:POTF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:POTF_ECOLI garnier swissprot:POTF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:POTF_ECOLI helixturnhelix swissprot:POTF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:POTF_ECOLI hmoment swissprot:POTF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:POTF_ECOLI iep swissprot:POTF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:POTF_ECOLI inforesidue swissprot:POTF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:POTF_ECOLI octanol swissprot:POTF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:POTF_ECOLI pepcoil swissprot:POTF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:POTF_ECOLI pepdigest swissprot:POTF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:POTF_ECOLI pepinfo swissprot:POTF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:POTF_ECOLI pepnet swissprot:POTF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:POTF_ECOLI pepstats swissprot:POTF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:POTF_ECOLI pepwheel swissprot:POTF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:POTF_ECOLI pepwindow swissprot:POTF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:POTF_ECOLI sigcleave swissprot:POTF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:POTF_ECOLI ## Database ID URL or Descriptions # BioGrid 4263137 618 # CDD cd04458 CSP_CDS # DISRUPTION PHENOTYPE Deletion represses the production of persister cells. {ECO:0000269|PubMed 19909729}. # EcoGene EG11111 cspD # FUNCTION CSPD_ECOLI Inhibits DNA replication at both initiation and elongation steps, most probably by binding to the opened, single- stranded regions at replication forks. Plays a regulatory role in chromosomal replication in nutrient-depleted cells. # FUNCTION CSPD_ECOLI Involved in persister cell formation, acting downstream of mRNA interferase (toxin) MqsR. Overproduction is toxic. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003697 single-stranded DNA binding; IDA:EcoCyc. # GO_function GO:0003723 RNA binding; IDA:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:InterPro. # GO_process GO:0008156 negative regulation of DNA replication; IDA:EcoCyc. # GO_process GO:0042594 response to starvation; IDA:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0003723 RNA binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # INDUCTION Not induced by cold-shock. Stationary-phase and starvation inducible, as well as by oxidative stress (30 mM H(2)O(2)). Repressed by MqsA and MqsRA toxin-antitoxin system. {ECO:0000269|PubMed 20105222}. # IntAct P0A968 39 # InterPro IPR002059 CSP_DNA-bd # InterPro IPR011129 Cold_shock_prot # InterPro IPR012156 Cold_shock_CspA # InterPro IPR012340 NA-bd_OB-fold # InterPro IPR012751 CspD # InterPro IPR019844 Cold-shock_CS # KEGG_Brite ko03000 Transcription factors # MISCELLANEOUS CSPD_ECOLI Binds single-stranded DNA and RNA, but not double- stranded DNA, through hydrophobic interactions without sequence specificity, resulting in a packed structure. # Organism CSPD_ECOLI Escherichia coli (strain K12) # PATRIC 32116969 VBIEscCol129921_0910 # PIR H64826 H64826 # PIRSF PIRSF002599 Cold_shock_A # PRINTS PR00050 COLDSHOCK # PROSITE PS00352 COLD_SHOCK # Pfam PF00313 CSD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CSPD_ECOLI Cold shock-like protein CspD # RefSeq NP_415401 NC_000913.3 # RefSeq WP_000410785 NZ_LN832404.1 # SIMILARITY Contains 1 CSD (cold-shock) domain. {ECO 0000305}. # SMART SM00357 CSP # SUBCELLULAR LOCATION CSPD_ECOLI Cytoplasm. # SUBUNIT CSPD_ECOLI Homodimer. # SUPFAM SSF50249 SSF50249 # TIGRFAMs TIGR02381 cspD # eggNOG COG1278 LUCA # eggNOG ENOG4105VEQ Bacteria BLAST swissprot:CSPD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CSPD_ECOLI BioCyc ECOL316407:JW0864-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0864-MONOMER BioCyc EcoCyc:EG11111-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11111-MONOMER COG COG1278 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1278 DIP DIP-47833N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47833N DOI 10.1016/j.bbrc.2009.11.033 http://dx.doi.org/10.1016/j.bbrc.2009.11.033 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2001.02345.x http://dx.doi.org/10.1046/j.1365-2958.2001.02345.x DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1462-2920.2009.02147.x http://dx.doi.org/10.1111/j.1462-2920.2009.02147.x DOI 10.1111/j.1574-6968.1998.tb13343.x http://dx.doi.org/10.1111/j.1574-6968.1998.tb13343.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M31045 http://www.ebi.ac.uk/ena/data/view/M31045 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1102 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1102 EcoGene EG11111 http://www.ecogene.org/geneInfo.php?eg_id=EG11111 EnsemblBacteria AAC73967 http://www.ensemblgenomes.org/id/AAC73967 EnsemblBacteria AAC73967 http://www.ensemblgenomes.org/id/AAC73967 EnsemblBacteria BAA35599 http://www.ensemblgenomes.org/id/BAA35599 EnsemblBacteria BAA35599 http://www.ensemblgenomes.org/id/BAA35599 EnsemblBacteria BAA35599 http://www.ensemblgenomes.org/id/BAA35599 EnsemblBacteria b0880 http://www.ensemblgenomes.org/id/b0880 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003697 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003697 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0008156 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008156 GO_process GO:0042594 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042594 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 945669 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945669 HOGENOM HOG000070674 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000070674&db=HOGENOM6 InParanoid P0A968 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A968 IntAct P0A968 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A968* InterPro IPR002059 http://www.ebi.ac.uk/interpro/entry/IPR002059 InterPro IPR011129 http://www.ebi.ac.uk/interpro/entry/IPR011129 InterPro IPR012156 http://www.ebi.ac.uk/interpro/entry/IPR012156 InterPro IPR012340 http://www.ebi.ac.uk/interpro/entry/IPR012340 InterPro IPR012751 http://www.ebi.ac.uk/interpro/entry/IPR012751 InterPro IPR019844 http://www.ebi.ac.uk/interpro/entry/IPR019844 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW0864 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0864 KEGG_Gene eco:b0880 http://www.genome.jp/dbget-bin/www_bget?eco:b0880 KEGG_Orthology KO:K03704 http://www.genome.jp/dbget-bin/www_bget?KO:K03704 MINT MINT-1219798 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1219798 OMA TSCSHIP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TSCSHIP PRINTS PR00050 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00050 PROSITE PS00352 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00352 PSORT swissprot:CSPD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CSPD_ECOLI PSORT-B swissprot:CSPD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CSPD_ECOLI PSORT2 swissprot:CSPD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CSPD_ECOLI Pfam PF00313 http://pfam.xfam.org/family/PF00313 Phobius swissprot:CSPD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CSPD_ECOLI PhylomeDB P0A968 http://phylomedb.org/?seqid=P0A968 ProteinModelPortal P0A968 http://www.proteinmodelportal.org/query/uniprot/P0A968 PubMed 11260474 http://www.ncbi.nlm.nih.gov/pubmed/11260474 PubMed 1622933 http://www.ncbi.nlm.nih.gov/pubmed/1622933 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19909729 http://www.ncbi.nlm.nih.gov/pubmed/19909729 PubMed 20105222 http://www.ncbi.nlm.nih.gov/pubmed/20105222 PubMed 2186030 http://www.ncbi.nlm.nih.gov/pubmed/2186030 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9868784 http://www.ncbi.nlm.nih.gov/pubmed/9868784 RefSeq NP_415401 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415401 RefSeq WP_000410785 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000410785 SMART SM00357 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00357 SMR P0A968 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A968 STRING 511145.b0880 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0880&targetmode=cogs STRING COG1278 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1278&targetmode=cogs SUPFAM SSF50249 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50249 TIGRFAMs TIGR02381 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02381 UniProtKB CSPD_ECOLI http://www.uniprot.org/uniprot/CSPD_ECOLI UniProtKB-AC P0A968 http://www.uniprot.org/uniprot/P0A968 charge swissprot:CSPD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CSPD_ECOLI eggNOG COG1278 http://eggnogapi.embl.de/nog_data/html/tree/COG1278 eggNOG ENOG4105VEQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VEQ epestfind swissprot:CSPD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CSPD_ECOLI garnier swissprot:CSPD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CSPD_ECOLI helixturnhelix swissprot:CSPD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CSPD_ECOLI hmoment swissprot:CSPD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CSPD_ECOLI iep swissprot:CSPD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CSPD_ECOLI inforesidue swissprot:CSPD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CSPD_ECOLI octanol swissprot:CSPD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CSPD_ECOLI pepcoil swissprot:CSPD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CSPD_ECOLI pepdigest swissprot:CSPD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CSPD_ECOLI pepinfo swissprot:CSPD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CSPD_ECOLI pepnet swissprot:CSPD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CSPD_ECOLI pepstats swissprot:CSPD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CSPD_ECOLI pepwheel swissprot:CSPD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CSPD_ECOLI pepwindow swissprot:CSPD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CSPD_ECOLI sigcleave swissprot:CSPD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CSPD_ECOLI ## Database ID URL or Descriptions # Organism YUAW_ECOLI Escherichia coli (strain K12) # RecName YUAW_ECOLI Uncharacterized protein YuaW # RefSeq NP_061416 NC_002483.1 # RefSeq WP_010892534 NC_002483.1 BLAST swissprot:YUAW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YUAW_ECOLI EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1263506 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263506 OMA DIANYCT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DIANYCT PSORT swissprot:YUAW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YUAW_ECOLI PSORT-B swissprot:YUAW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YUAW_ECOLI PSORT2 swissprot:YUAW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YUAW_ECOLI Phobius swissprot:YUAW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YUAW_ECOLI ProteinModelPortal Q9JMR8 http://www.proteinmodelportal.org/query/uniprot/Q9JMR8 RefSeq NP_061416 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061416 RefSeq WP_010892534 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_010892534 SMR Q9JMR8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9JMR8 UniProtKB YUAW_ECOLI http://www.uniprot.org/uniprot/YUAW_ECOLI UniProtKB-AC Q9JMR8 http://www.uniprot.org/uniprot/Q9JMR8 charge swissprot:YUAW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YUAW_ECOLI epestfind swissprot:YUAW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YUAW_ECOLI garnier swissprot:YUAW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YUAW_ECOLI helixturnhelix swissprot:YUAW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YUAW_ECOLI hmoment swissprot:YUAW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YUAW_ECOLI iep swissprot:YUAW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YUAW_ECOLI inforesidue swissprot:YUAW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YUAW_ECOLI octanol swissprot:YUAW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YUAW_ECOLI pepcoil swissprot:YUAW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YUAW_ECOLI pepdigest swissprot:YUAW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YUAW_ECOLI pepinfo swissprot:YUAW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YUAW_ECOLI pepnet swissprot:YUAW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YUAW_ECOLI pepstats swissprot:YUAW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YUAW_ECOLI pepwheel swissprot:YUAW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YUAW_ECOLI pepwindow swissprot:YUAW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YUAW_ECOLI sigcleave swissprot:YUAW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YUAW_ECOLI ## Database ID URL or Descriptions # BioGrid 4259128 77 # EcoGene EG13833 ydfU # IntAct P76162 2 # InterPro IPR003615 HNH_nuc # InterPro IPR010373 DUF968 # Organism YDFU_ECOLI Escherichia coli (strain K12) # PATRIC 32118422 VBIEscCol129921_1631 # PIR C64911 C64911 # Pfam PF06147 DUF968 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDFU_ECOLI Uncharacterized protein YdfU # RefSeq NP_416078 NC_000913.3 # SMART SM00507 HNHc # eggNOG ENOG4108MXB Bacteria # eggNOG ENOG410ZRYP LUCA BLAST swissprot:YDFU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDFU_ECOLI BioCyc ECOL316407:JW5909-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5909-MONOMER BioCyc EcoCyc:G6831-MONOMER http://biocyc.org/getid?id=EcoCyc:G6831-MONOMER DIP DIP-48000N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48000N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3594 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3594 EcoGene EG13833 http://www.ecogene.org/geneInfo.php?eg_id=EG13833 EnsemblBacteria AAC74633 http://www.ensemblgenomes.org/id/AAC74633 EnsemblBacteria AAC74633 http://www.ensemblgenomes.org/id/AAC74633 EnsemblBacteria BAA15259 http://www.ensemblgenomes.org/id/BAA15259 EnsemblBacteria BAA15259 http://www.ensemblgenomes.org/id/BAA15259 EnsemblBacteria BAA15259 http://www.ensemblgenomes.org/id/BAA15259 EnsemblBacteria b1560 http://www.ensemblgenomes.org/id/b1560 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946108 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946108 HOGENOM HOG000119975 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000119975&db=HOGENOM6 IntAct P76162 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76162* InterPro IPR003615 http://www.ebi.ac.uk/interpro/entry/IPR003615 InterPro IPR010373 http://www.ebi.ac.uk/interpro/entry/IPR010373 KEGG_Gene ecj:JW5909 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5909 KEGG_Gene eco:b1560 http://www.genome.jp/dbget-bin/www_bget?eco:b1560 PSORT swissprot:YDFU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDFU_ECOLI PSORT-B swissprot:YDFU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDFU_ECOLI PSORT2 swissprot:YDFU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDFU_ECOLI Pfam PF06147 http://pfam.xfam.org/family/PF06147 Phobius swissprot:YDFU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDFU_ECOLI ProteinModelPortal P76162 http://www.proteinmodelportal.org/query/uniprot/P76162 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416078 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416078 SMART SM00507 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00507 STRING 511145.b1560 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1560&targetmode=cogs UniProtKB YDFU_ECOLI http://www.uniprot.org/uniprot/YDFU_ECOLI UniProtKB-AC P76162 http://www.uniprot.org/uniprot/P76162 charge swissprot:YDFU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDFU_ECOLI eggNOG ENOG4108MXB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MXB eggNOG ENOG410ZRYP http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZRYP epestfind swissprot:YDFU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDFU_ECOLI garnier swissprot:YDFU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDFU_ECOLI helixturnhelix swissprot:YDFU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDFU_ECOLI hmoment swissprot:YDFU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDFU_ECOLI iep swissprot:YDFU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDFU_ECOLI inforesidue swissprot:YDFU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDFU_ECOLI octanol swissprot:YDFU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDFU_ECOLI pepcoil swissprot:YDFU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDFU_ECOLI pepdigest swissprot:YDFU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDFU_ECOLI pepinfo swissprot:YDFU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDFU_ECOLI pepnet swissprot:YDFU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDFU_ECOLI pepstats swissprot:YDFU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDFU_ECOLI pepwheel swissprot:YDFU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDFU_ECOLI pepwindow swissprot:YDFU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDFU_ECOLI sigcleave swissprot:YDFU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDFU_ECOLI ## Database ID URL or Descriptions # BioGrid 4262396 61 # EcoGene EG12185 yqiB # IntAct P0ADU7 7 # InterPro IPR009659 DUF1249 # Organism YQIB_ECOLI Escherichia coli (strain K12) # PATRIC 32121476 VBIEscCol129921_3125 # PIR G65090 G65090 # Pfam PF06853 DUF1249 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQIB_ECOLI Uncharacterized protein YqiB # RefSeq NP_417505 NC_000913.3 # RefSeq WP_000833393 NZ_LN832404.1 # eggNOG COG3151 LUCA # eggNOG ENOG4108SX3 Bacteria BLAST swissprot:YQIB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQIB_ECOLI BioCyc ECOL316407:JW3001-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3001-MONOMER BioCyc EcoCyc:G7580-MONOMER http://biocyc.org/getid?id=EcoCyc:G7580-MONOMER COG COG3151 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3151 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.271.41.25423 http://dx.doi.org/10.1074/jbc.271.41.25423 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D16557 http://www.ebi.ac.uk/ena/data/view/D16557 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2102 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2102 EcoGene EG12185 http://www.ecogene.org/geneInfo.php?eg_id=EG12185 EnsemblBacteria AAC76069 http://www.ensemblgenomes.org/id/AAC76069 EnsemblBacteria AAC76069 http://www.ensemblgenomes.org/id/AAC76069 EnsemblBacteria BAE77089 http://www.ensemblgenomes.org/id/BAE77089 EnsemblBacteria BAE77089 http://www.ensemblgenomes.org/id/BAE77089 EnsemblBacteria BAE77089 http://www.ensemblgenomes.org/id/BAE77089 EnsemblBacteria b3033 http://www.ensemblgenomes.org/id/b3033 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947518 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947518 HOGENOM HOG000283494 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000283494&db=HOGENOM6 InParanoid P0ADU7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADU7 IntAct P0ADU7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADU7* InterPro IPR009659 http://www.ebi.ac.uk/interpro/entry/IPR009659 KEGG_Gene ecj:JW3001 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3001 KEGG_Gene eco:b3033 http://www.genome.jp/dbget-bin/www_bget?eco:b3033 KEGG_Orthology KO:K09920 http://www.genome.jp/dbget-bin/www_bget?KO:K09920 OMA NAAMHQP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NAAMHQP PSORT swissprot:YQIB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQIB_ECOLI PSORT-B swissprot:YQIB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQIB_ECOLI PSORT2 swissprot:YQIB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQIB_ECOLI Pfam PF06853 http://pfam.xfam.org/family/PF06853 Phobius swissprot:YQIB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQIB_ECOLI ProteinModelPortal P0ADU7 http://www.proteinmodelportal.org/query/uniprot/P0ADU7 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8810311 http://www.ncbi.nlm.nih.gov/pubmed/8810311 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417505 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417505 RefSeq WP_000833393 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000833393 STRING 511145.b3033 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3033&targetmode=cogs STRING COG3151 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3151&targetmode=cogs UniProtKB YQIB_ECOLI http://www.uniprot.org/uniprot/YQIB_ECOLI UniProtKB-AC P0ADU7 http://www.uniprot.org/uniprot/P0ADU7 charge swissprot:YQIB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQIB_ECOLI eggNOG COG3151 http://eggnogapi.embl.de/nog_data/html/tree/COG3151 eggNOG ENOG4108SX3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108SX3 epestfind swissprot:YQIB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQIB_ECOLI garnier swissprot:YQIB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQIB_ECOLI helixturnhelix swissprot:YQIB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQIB_ECOLI hmoment swissprot:YQIB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQIB_ECOLI iep swissprot:YQIB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQIB_ECOLI inforesidue swissprot:YQIB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQIB_ECOLI octanol swissprot:YQIB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQIB_ECOLI pepcoil swissprot:YQIB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQIB_ECOLI pepdigest swissprot:YQIB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQIB_ECOLI pepinfo swissprot:YQIB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQIB_ECOLI pepnet swissprot:YQIB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQIB_ECOLI pepstats swissprot:YQIB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQIB_ECOLI pepwheel swissprot:YQIB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQIB_ECOLI pepwindow swissprot:YQIB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQIB_ECOLI sigcleave swissprot:YQIB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQIB_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES ALR1_ECOLI Kinetic parameters KM=0.31 mM for D-alanine {ECO 0000269|PubMed 18434499}; KM=1.00 mM for L-alanine {ECO 0000269|PubMed 18434499}; # BRENDA 5.1.1 2026 # BioGrid 4260823 598 # CATALYTIC ACTIVITY L-alanine = D-alanine. {ECO:0000269|PubMed 18434499}. # COFACTOR ALR1_ECOLI Name=pyridoxal 5'-phosphate; Xref=ChEBI CHEBI 597326; Evidence={ECO 0000269|PubMed 18434499}; # EcoGene EG10001 alr # FUNCTION ALR1_ECOLI Catalyzes the interconversion of L-alanine and D- alanine. Provides the D-alanine required for cell wall biosynthesis. {ECO 0000269|PubMed 18434499}. # GO_function GO:0008784 alanine racemase activity; IDA:EcoCyc. # GO_function GO:0030170 pyridoxal phosphate binding; IDA:EcoCyc. # GO_process GO:0008360 regulation of cell shape; IEA:UniProtKB-KW. # GO_process GO:0009252 peptidoglycan biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0030632 D-alanine biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 2.40.37.10 -; 1. # Gene3D 3.20.20.10 -; 1. # HAMAP MF_01201 Ala_racemase # IntAct P0A6B4 6 # InterPro IPR000821 Ala_racemase # InterPro IPR001608 Ala_racemase_N # InterPro IPR009006 Ala_racemase/Decarboxylase_C # InterPro IPR011079 Ala_racemase_C # InterPro IPR020622 Ala_racemase_pyridoxalP-BS # InterPro IPR029066 PLP-binding_barrel # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00473 D-Alanine metabolism # Organism ALR1_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; D-alanine biosynthesis; D- alanine from L-alanine: step 1/1. {ECO 0000269|PubMed:18434499}. # PATHWAY Cell wall biogenesis; peptidoglycan biosynthesis. {ECO:0000305|PubMed 18434499}. # PATRIC 32123645 VBIEscCol129921_4171 # PDB 2RJG X-ray; 2.40 A; A/B/C/D=1-359 # PDB 2RJH X-ray; 2.40 A; A/B/C/D=1-359 # PDB 3B8T X-ray; 3.00 A; A/B/C/D=1-359 # PDB 3B8U X-ray; 3.00 A; A/B/C/D=1-359 # PDB 3B8V X-ray; 2.60 A; A/B/C/D=1-359 # PDB 3B8W X-ray; 2.70 A; A/B/C/D=1-359 # PDB 4WR3 X-ray; 1.90 A; A/B/C/D=1-359 # PDB 4XBJ X-ray; 2.25 A; A/B/C/D=1-359 # PIR D65213 PC1296 # PRINTS PR00992 ALARACEMASE # PROSITE PS00395 ALANINE_RACEMASE # Pfam PF00842 Ala_racemase_C # Pfam PF01168 Ala_racemase_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Alanine racemase, biosynthetic {ECO:0000305|PubMed 18434499} # RefSeq NP_418477 NC_000913.3 # RefSeq WP_001147328 NZ_LN832404.1 # SIMILARITY Belongs to the alanine racemase family. {ECO:0000255|HAMAP-Rule MF_01201}. # SMART SM01005 Ala_racemase_C # SUBUNIT Homodimer. {ECO:0000269|PubMed 18434499}. # SUPFAM SSF50621 SSF50621 # SUPFAM SSF51419 SSF51419 # TIGRFAMs TIGR00492 alr # UniPathway UPA00042 UER00497 # eggNOG COG0787 LUCA # eggNOG ENOG4105CJ4 Bacteria BLAST swissprot:ALR1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ALR1_ECOLI BioCyc ECOL316407:JW4013-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4013-MONOMER BioCyc EcoCyc:ALARACEBIOSYN-MONOMER http://biocyc.org/getid?id=EcoCyc:ALARACEBIOSYN-MONOMER BioCyc MetaCyc:ALARACEBIOSYN-MONOMER http://biocyc.org/getid?id=MetaCyc:ALARACEBIOSYN-MONOMER COG COG0787 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0787 DOI 10.1016/0006-291X(85)91851-0 http://dx.doi.org/10.1016/0006-291X(85)91851-0 DOI 10.1016/0378-1119(93)90690-5 http://dx.doi.org/10.1016/0378-1119(93)90690-5 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1110/ps.083495908 http://dx.doi.org/10.1110/ps.083495908 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.1.1.1 {ECO:0000269|PubMed:18434499} http://www.genome.jp/dbget-bin/www_bget?EC:5.1.1.1 {ECO:0000269|PubMed:18434499} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K01174 http://www.ebi.ac.uk/ena/data/view/K01174 EMBL M12047 http://www.ebi.ac.uk/ena/data/view/M12047 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 5.1.1.1 {ECO:0000269|PubMed:18434499} http://enzyme.expasy.org/EC/5.1.1.1 {ECO:0000269|PubMed:18434499} EchoBASE EB0001 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0001 EcoGene EG10001 http://www.ecogene.org/geneInfo.php?eg_id=EG10001 EnsemblBacteria AAC77023 http://www.ensemblgenomes.org/id/AAC77023 EnsemblBacteria AAC77023 http://www.ensemblgenomes.org/id/AAC77023 EnsemblBacteria BAE78055 http://www.ensemblgenomes.org/id/BAE78055 EnsemblBacteria BAE78055 http://www.ensemblgenomes.org/id/BAE78055 EnsemblBacteria BAE78055 http://www.ensemblgenomes.org/id/BAE78055 EnsemblBacteria b4053 http://www.ensemblgenomes.org/id/b4053 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008784 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008784 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0009252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009252 GO_process GO:0030632 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030632 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 2.40.37.10 http://www.cathdb.info/version/latest/superfamily/2.40.37.10 Gene3D 3.20.20.10 http://www.cathdb.info/version/latest/superfamily/3.20.20.10 GeneID 948564 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948564 HAMAP MF_01201 http://hamap.expasy.org/unirule/MF_01201 HOGENOM HOG000031446 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000031446&db=HOGENOM6 InParanoid P0A6B4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6B4 IntAct P0A6B4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6B4* IntEnz 5.1.1.1 {ECO:0000269|PubMed:18434499} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.1.1.1 {ECO:0000269|PubMed:18434499} InterPro IPR000821 http://www.ebi.ac.uk/interpro/entry/IPR000821 InterPro IPR001608 http://www.ebi.ac.uk/interpro/entry/IPR001608 InterPro IPR009006 http://www.ebi.ac.uk/interpro/entry/IPR009006 InterPro IPR011079 http://www.ebi.ac.uk/interpro/entry/IPR011079 InterPro IPR020622 http://www.ebi.ac.uk/interpro/entry/IPR020622 InterPro IPR029066 http://www.ebi.ac.uk/interpro/entry/IPR029066 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4013 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4013 KEGG_Gene eco:b4053 http://www.genome.jp/dbget-bin/www_bget?eco:b4053 KEGG_Orthology KO:K01775 http://www.genome.jp/dbget-bin/www_bget?KO:K01775 KEGG_Pathway ko00473 http://www.genome.jp/kegg-bin/show_pathway?ko00473 KEGG_Reaction rn:R00401 http://www.genome.jp/dbget-bin/www_bget?rn:R00401 OMA THAKNQM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=THAKNQM PDB 2RJG http://www.ebi.ac.uk/pdbe-srv/view/entry/2RJG PDB 2RJH http://www.ebi.ac.uk/pdbe-srv/view/entry/2RJH PDB 3B8T http://www.ebi.ac.uk/pdbe-srv/view/entry/3B8T PDB 3B8U http://www.ebi.ac.uk/pdbe-srv/view/entry/3B8U PDB 3B8V http://www.ebi.ac.uk/pdbe-srv/view/entry/3B8V PDB 3B8W http://www.ebi.ac.uk/pdbe-srv/view/entry/3B8W PDB 4WR3 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WR3 PDB 4XBJ http://www.ebi.ac.uk/pdbe-srv/view/entry/4XBJ PDBsum 2RJG http://www.ebi.ac.uk/pdbsum/2RJG PDBsum 2RJH http://www.ebi.ac.uk/pdbsum/2RJH PDBsum 3B8T http://www.ebi.ac.uk/pdbsum/3B8T PDBsum 3B8U http://www.ebi.ac.uk/pdbsum/3B8U PDBsum 3B8V http://www.ebi.ac.uk/pdbsum/3B8V PDBsum 3B8W http://www.ebi.ac.uk/pdbsum/3B8W PDBsum 4WR3 http://www.ebi.ac.uk/pdbsum/4WR3 PDBsum 4XBJ http://www.ebi.ac.uk/pdbsum/4XBJ PRINTS PR00992 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00992 PROSITE PS00395 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00395 PSORT swissprot:ALR1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ALR1_ECOLI PSORT-B swissprot:ALR1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ALR1_ECOLI PSORT2 swissprot:ALR1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ALR1_ECOLI Pfam PF00842 http://pfam.xfam.org/family/PF00842 Pfam PF01168 http://pfam.xfam.org/family/PF01168 Phobius swissprot:ALR1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ALR1_ECOLI PhylomeDB P0A6B4 http://phylomedb.org/?seqid=P0A6B4 ProteinModelPortal P0A6B4 http://www.proteinmodelportal.org/query/uniprot/P0A6B4 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18434499 http://www.ncbi.nlm.nih.gov/pubmed/18434499 PubMed 3907634 http://www.ncbi.nlm.nih.gov/pubmed/3907634 PubMed 6323420 http://www.ncbi.nlm.nih.gov/pubmed/6323420 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 8335265 http://www.ncbi.nlm.nih.gov/pubmed/8335265 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418477 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418477 RefSeq WP_001147328 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001147328 SMART SM01005 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01005 SMR P0A6B4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6B4 STRING 511145.b4053 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4053&targetmode=cogs STRING COG0787 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0787&targetmode=cogs SUPFAM SSF50621 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50621 SUPFAM SSF51419 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51419 TIGRFAMs TIGR00492 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00492 UniProtKB ALR1_ECOLI http://www.uniprot.org/uniprot/ALR1_ECOLI UniProtKB-AC P0A6B4 http://www.uniprot.org/uniprot/P0A6B4 charge swissprot:ALR1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ALR1_ECOLI eggNOG COG0787 http://eggnogapi.embl.de/nog_data/html/tree/COG0787 eggNOG ENOG4105CJ4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CJ4 epestfind swissprot:ALR1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ALR1_ECOLI garnier swissprot:ALR1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ALR1_ECOLI helixturnhelix swissprot:ALR1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ALR1_ECOLI hmoment swissprot:ALR1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ALR1_ECOLI iep swissprot:ALR1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ALR1_ECOLI inforesidue swissprot:ALR1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ALR1_ECOLI octanol swissprot:ALR1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ALR1_ECOLI pepcoil swissprot:ALR1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ALR1_ECOLI pepdigest swissprot:ALR1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ALR1_ECOLI pepinfo swissprot:ALR1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ALR1_ECOLI pepnet swissprot:ALR1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ALR1_ECOLI pepstats swissprot:ALR1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ALR1_ECOLI pepwheel swissprot:ALR1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ALR1_ECOLI pepwindow swissprot:ALR1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ALR1_ECOLI sigcleave swissprot:ALR1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ALR1_ECOLI ## Database ID URL or Descriptions # CAUTION There is no equivalent of this gene in strain K12 / MG1655. {ECO 0000305}. # FUNCTION INH16_ECOLI Involved in the transposition of the insertion sequence IS5. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # InterPro IPR002559 Transposase_11 # InterPro IPR008490 Transposase_InsH_N # Organism INH16_ECOLI Escherichia coli (strain K12) # Pfam PF01609 DDE_Tnp_1 # Pfam PF05598 DUF772 # RecName INH16_ECOLI Transposase InsH for insertion sequence element IS5-16 # RefSeq WP_000019403 NZ_LN832404.1 # SIMILARITY Belongs to the transposase 11 family. {ECO 0000305}. # eggNOG COG3039 LUCA # eggNOG ENOG4105F2I Bacteria BLAST swissprot:INH16_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INH16_ECOLI DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EnsemblBacteria BAE77582 http://www.ensemblgenomes.org/id/BAE77582 EnsemblBacteria BAE77582 http://www.ensemblgenomes.org/id/BAE77582 EnsemblBacteria BAE77582 http://www.ensemblgenomes.org/id/BAE77582 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 InterPro IPR002559 http://www.ebi.ac.uk/interpro/entry/IPR002559 InterPro IPR008490 http://www.ebi.ac.uk/interpro/entry/IPR008490 KEGG_Gene ecj:JW5935 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5935 PSORT swissprot:INH16_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INH16_ECOLI PSORT-B swissprot:INH16_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INH16_ECOLI PSORT2 swissprot:INH16_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INH16_ECOLI Pfam PF01609 http://pfam.xfam.org/family/PF01609 Pfam PF05598 http://pfam.xfam.org/family/PF05598 Phobius swissprot:INH16_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INH16_ECOLI PhylomeDB P0CE63 http://phylomedb.org/?seqid=P0CE63 ProteinModelPortal P0CE63 http://www.proteinmodelportal.org/query/uniprot/P0CE63 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 RefSeq WP_000019403 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000019403 SMR P0CE63 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0CE63 STRING 511145.b3505 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3505&targetmode=cogs UniProtKB INH16_ECOLI http://www.uniprot.org/uniprot/INH16_ECOLI UniProtKB-AC P0CE63 http://www.uniprot.org/uniprot/P0CE63 charge swissprot:INH16_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INH16_ECOLI eggNOG COG3039 http://eggnogapi.embl.de/nog_data/html/tree/COG3039 eggNOG ENOG4105F2I http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F2I epestfind swissprot:INH16_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INH16_ECOLI garnier swissprot:INH16_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INH16_ECOLI helixturnhelix swissprot:INH16_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INH16_ECOLI hmoment swissprot:INH16_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INH16_ECOLI iep swissprot:INH16_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INH16_ECOLI inforesidue swissprot:INH16_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INH16_ECOLI octanol swissprot:INH16_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INH16_ECOLI pepcoil swissprot:INH16_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INH16_ECOLI pepdigest swissprot:INH16_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INH16_ECOLI pepinfo swissprot:INH16_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INH16_ECOLI pepnet swissprot:INH16_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INH16_ECOLI pepstats swissprot:INH16_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INH16_ECOLI pepwheel swissprot:INH16_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INH16_ECOLI pepwindow swissprot:INH16_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INH16_ECOLI sigcleave swissprot:INH16_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INH16_ECOLI ## Database ID URL or Descriptions # BioGrid 4260467 7 # EcoGene EG12036 yeiQ # GO_function GO:0016491 oxidoreductase activity; IBA:GO_Central. # GO_function GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IBA:GO_Central. # GO_function GO:0050662 coenzyme binding; IEA:InterPro. # GO_process GO:0019594 mannitol metabolic process; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.1040.10 -; 1. # Gene3D 3.40.50.720 -; 1. # InterPro IPR000669 Mannitol_DH # InterPro IPR008927 6-PGluconate_DH_C-like # InterPro IPR013118 Mannitol_DH_C # InterPro IPR013131 Mannitol_DH_N # InterPro IPR013328 6PGD_dom_2 # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR023027 Mannitol_DH_CS # KEGG_Brite ko01000 Enzymes # Organism YEIQ_ECOLI Escherichia coli (strain K12) # PATRIC 32119699 VBIEscCol129921_2260 # PIR C64986 C64986 # PRINTS PR00084 MTLDHDRGNASE # PROSITE PS00974 MANNITOL_DHGENASE # Pfam PF01232 Mannitol_dh # Pfam PF08125 Mannitol_dh_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEIQ_ECOLI Uncharacterized oxidoreductase YeiQ # RefSeq NP_416677 NC_000913.3 # RefSeq WP_001091940 NZ_LN832404.1 # SIMILARITY Belongs to the mannitol dehydrogenase family. UxuB subfamily. {ECO 0000305}. # SUPFAM SSF48179 SSF48179 # SUPFAM SSF51735 SSF51735 # eggNOG COG0246 LUCA # eggNOG ENOG4105DEI Bacteria BLAST swissprot:YEIQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEIQ_ECOLI BioCyc ECOL316407:JW2160-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2160-MONOMER BioCyc EcoCyc:EG12036-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12036-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- EchoBASE EB1971 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1971 EcoGene EG12036 http://www.ecogene.org/geneInfo.php?eg_id=EG12036 EnsemblBacteria AAC75233 http://www.ensemblgenomes.org/id/AAC75233 EnsemblBacteria AAC75233 http://www.ensemblgenomes.org/id/AAC75233 EnsemblBacteria BAA15981 http://www.ensemblgenomes.org/id/BAA15981 EnsemblBacteria BAA15981 http://www.ensemblgenomes.org/id/BAA15981 EnsemblBacteria BAA15981 http://www.ensemblgenomes.org/id/BAA15981 EnsemblBacteria b2172 http://www.ensemblgenomes.org/id/b2172 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0016616 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016616 GO_function GO:0050662 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050662 GO_process GO:0019594 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019594 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.1040.10 http://www.cathdb.info/version/latest/superfamily/1.10.1040.10 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 946688 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946688 HOGENOM HOG000202982 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000202982&db=HOGENOM6 InParanoid P33029 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33029 IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR000669 http://www.ebi.ac.uk/interpro/entry/IPR000669 InterPro IPR008927 http://www.ebi.ac.uk/interpro/entry/IPR008927 InterPro IPR013118 http://www.ebi.ac.uk/interpro/entry/IPR013118 InterPro IPR013131 http://www.ebi.ac.uk/interpro/entry/IPR013131 InterPro IPR013328 http://www.ebi.ac.uk/interpro/entry/IPR013328 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR023027 http://www.ebi.ac.uk/interpro/entry/IPR023027 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2160 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2160 KEGG_Gene eco:b2172 http://www.genome.jp/dbget-bin/www_bget?eco:b2172 KEGG_Orthology KO:K00540 http://www.genome.jp/dbget-bin/www_bget?KO:K00540 OMA GIVHIGP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GIVHIGP PRINTS PR00084 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00084 PROSITE PS00974 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00974 PSORT swissprot:YEIQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEIQ_ECOLI PSORT-B swissprot:YEIQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEIQ_ECOLI PSORT2 swissprot:YEIQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEIQ_ECOLI Pfam PF01232 http://pfam.xfam.org/family/PF01232 Pfam PF08125 http://pfam.xfam.org/family/PF08125 Phobius swissprot:YEIQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEIQ_ECOLI PhylomeDB P33029 http://phylomedb.org/?seqid=P33029 ProteinModelPortal P33029 http://www.proteinmodelportal.org/query/uniprot/P33029 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416677 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416677 RefSeq WP_001091940 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001091940 SMR P33029 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33029 STRING 511145.b2172 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2172&targetmode=cogs SUPFAM SSF48179 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48179 SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB YEIQ_ECOLI http://www.uniprot.org/uniprot/YEIQ_ECOLI UniProtKB-AC P33029 http://www.uniprot.org/uniprot/P33029 charge swissprot:YEIQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEIQ_ECOLI eggNOG COG0246 http://eggnogapi.embl.de/nog_data/html/tree/COG0246 eggNOG ENOG4105DEI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DEI epestfind swissprot:YEIQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEIQ_ECOLI garnier swissprot:YEIQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEIQ_ECOLI helixturnhelix swissprot:YEIQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEIQ_ECOLI hmoment swissprot:YEIQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEIQ_ECOLI iep swissprot:YEIQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEIQ_ECOLI inforesidue swissprot:YEIQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEIQ_ECOLI octanol swissprot:YEIQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEIQ_ECOLI pepcoil swissprot:YEIQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEIQ_ECOLI pepdigest swissprot:YEIQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEIQ_ECOLI pepinfo swissprot:YEIQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEIQ_ECOLI pepnet swissprot:YEIQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEIQ_ECOLI pepstats swissprot:YEIQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEIQ_ECOLI pepwheel swissprot:YEIQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEIQ_ECOLI pepwindow swissprot:YEIQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEIQ_ECOLI sigcleave swissprot:YEIQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEIQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4259797 12 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG13381 ykgA # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_function GO:0019172 glyoxalase III activity; IBA:GO_Central. # GO_function GO:0043565 sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; ISS:EcoCyc. # GO_process GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione; IBA:GO_Central. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.10.60 -; 2. # Gene3D 3.20.80.10 -; 1. # InterPro IPR009057 Homeodomain-like # InterPro IPR011256 Reg_factor_effector_dom # InterPro IPR018060 HTH_AraC # InterPro IPR020449 Tscrpt_reg_HTH_AraC-type # Organism YKGA_ECOLI Escherichia coli (strain K12) # PATRIC 48659806 VBIEscCol107702_0298 # PIR D64756 D64756 # PRINTS PR00032 HTHARAC # PROSITE PS01124 HTH_ARAC_FAMILY_2 # Pfam PF12833 HTH_18 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YKGA_ECOLI Putative HTH-type transcriptional regulator YkgA # SEQUENCE CAUTION Sequence=BAE76085.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Contains 1 HTH araC/xylS-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00593}. # SMART SM00342 HTH_ARAC # SUPFAM SSF46689 SSF46689; 2 # SUPFAM SSF55136 SSF55136 BLAST swissprot:YKGA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YKGA_ECOLI BioCyc ECOL316407:JW5037-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5037-MONOMER BioCyc EcoCyc:G6170-MONOMER http://biocyc.org/getid?id=EcoCyc:G6170-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB3162 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3162 EcoGene EG13381 http://www.ecogene.org/geneInfo.php?eg_id=EG13381 EnsemblBacteria BAE76085 http://www.ensemblgenomes.org/id/BAE76085 EnsemblBacteria BAE76085 http://www.ensemblgenomes.org/id/BAE76085 EnsemblBacteria BAE76085 http://www.ensemblgenomes.org/id/BAE76085 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0019172 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019172 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0019243 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019243 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 Gene3D 3.20.80.10 http://www.cathdb.info/version/latest/superfamily/3.20.80.10 HOGENOM HOG000117268 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117268&db=HOGENOM6 InParanoid P77601 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77601 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR011256 http://www.ebi.ac.uk/interpro/entry/IPR011256 InterPro IPR018060 http://www.ebi.ac.uk/interpro/entry/IPR018060 InterPro IPR020449 http://www.ebi.ac.uk/interpro/entry/IPR020449 KEGG_Gene ecj:JW5037 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5037 OMA DSCIVER http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DSCIVER PRINTS PR00032 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00032 PROSITE PS01124 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01124 PSORT swissprot:YKGA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YKGA_ECOLI PSORT-B swissprot:YKGA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YKGA_ECOLI PSORT2 swissprot:YKGA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YKGA_ECOLI Pfam PF12833 http://pfam.xfam.org/family/PF12833 Phobius swissprot:YKGA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YKGA_ECOLI PhylomeDB P77601 http://phylomedb.org/?seqid=P77601 ProteinModelPortal P77601 http://www.proteinmodelportal.org/query/uniprot/P77601 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SMART SM00342 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00342 SMR P77601 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77601 STRING 316407.85674445 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85674445&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF55136 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55136 UniProtKB YKGA_ECOLI http://www.uniprot.org/uniprot/YKGA_ECOLI UniProtKB-AC P77601 http://www.uniprot.org/uniprot/P77601 charge swissprot:YKGA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YKGA_ECOLI epestfind swissprot:YKGA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YKGA_ECOLI garnier swissprot:YKGA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YKGA_ECOLI helixturnhelix swissprot:YKGA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YKGA_ECOLI hmoment swissprot:YKGA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YKGA_ECOLI iep swissprot:YKGA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YKGA_ECOLI inforesidue swissprot:YKGA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YKGA_ECOLI octanol swissprot:YKGA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YKGA_ECOLI pepcoil swissprot:YKGA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YKGA_ECOLI pepdigest swissprot:YKGA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YKGA_ECOLI pepinfo swissprot:YKGA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YKGA_ECOLI pepnet swissprot:YKGA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YKGA_ECOLI pepstats swissprot:YKGA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YKGA_ECOLI pepwheel swissprot:YKGA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YKGA_ECOLI pepwindow swissprot:YKGA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YKGA_ECOLI sigcleave swissprot:YKGA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YKGA_ECOLI ## Database ID URL or Descriptions # AltName SYA_ECOLI Alanyl-tRNA synthetase # BRENDA 6.1.1 2026 # CATALYTIC ACTIVITY SYA_ECOLI ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala). # COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI 29105; Note=Binds 1 zinc ion per subunit; it is not clear where this binding occurs.; # DOMAIN SYA_ECOLI Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs. # DOMAIN SYA_ECOLI The C-terminal C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs. This C-Ala domain can be replaced in vitro by the corresponding domain of Aquifex aeolicus or man. Recognition of tRNA(Ala) by the 2 domains is independent, that is one enzyme recognizes the same tRNA(Ala) in 2 different manners. {ECO 0000305}. # DOMAIN SYA_ECOLI The editing domain removes incorrectly charged amino acids, i.e. Ser-tRNA(Ala) or Gly-tRNA(Ala) become uncharged tRNA(Ala) and the amino acid. It is specific for the acceptor stem of tRNA(Ala). # EcoGene EG10034 alaS # FUNCTION SYA_ECOLI Attaches Ala to transfer-messenger RNA (tmRNA, also known as 10Sa RNA, the product of the ssrA gene). tmRNA plays a major role in rescue of stalled ribosomes via trans-translation. {ECO 0000269|PubMed 7524073}. # FUNCTION SYA_ECOLI Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). AlaRS also incorrectly activates the sterically smaller than alanine amino acid glycine as well as the sterically larger amino acid serine. These incorrectly charged amino acids occur because the of inherent physicochemical limitations on discrimination between closely related amino acids (glycine and serine) in the charging step. # FUNCTION SYA_ECOLI Edits incorrectly charged Ser-tRNA(Ala) and Gly- tRNA(Ala) but not incorrectly charged Ser-tRNA(Thr). # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0000049 tRNA binding; IBA:GO_Central. # GO_function GO:0001141 transcriptional repressor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding; IDA:EcoCyc. # GO_function GO:0002161 aminoacyl-tRNA editing activity; IDA:UniProtKB. # GO_function GO:0004813 alanine-tRNA ligase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_function GO:0016597 amino acid binding; IBA:GO_Central. # GO_process GO:0006400 tRNA modification; IBA:GO_Central. # GO_process GO:0006419 alanyl-tRNA aminoacylation; IDA:EcoCyc. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0008150 biological_process # HAMAP MF_00036_B Ala_tRNA_synth_B # INTERACTION SYA_ECOLI Self; NbExp=2; IntAct=EBI-544061, EBI-544061; # IntAct P00957 19 # InterPro IPR002318 Ala-tRNA-lgiase_IIc # InterPro IPR003156 DHHA1_dom # InterPro IPR009000 Transl_B-barrel # InterPro IPR012947 tRNA_SAD # InterPro IPR018162 Ala-tRNA-ligase_IIc_anticod-bd # InterPro IPR018163 Thr/Ala-tRNA-synth_IIc_edit # InterPro IPR018164 Ala-tRNA-synth_IIc_N # InterPro IPR018165 Ala-tRNA-synth_IIc_core # InterPro IPR023033 Ala_tRNA_ligase_euk/bac # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01007 Amino acid related enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # KEGG_Pathway ko00970 Aminoacyl-tRNA biosynthesis # Organism SYA_ECOLI Escherichia coli (strain K12) # PATRIC 32120790 VBIEscCol129921_2787 # PDB 3HXU X-ray; 2.10 A; A=2-442 # PDB 3HXV X-ray; 1.93 A; A=2-442 # PDB 3HXW X-ray; 1.93 A; A=2-442 # PDB 3HXX X-ray; 2.11 A; A=2-442 # PDB 3HXY X-ray; 2.27 A; A=2-442 # PDB 3HXZ X-ray; 1.99 A; A/B/C/D=2-442 # PDB 3HY0 X-ray; 1.90 A; A/B=2-442 # PDB 3HY1 X-ray; 2.79 A; A/B=2-442 # PIR E65049 SYECAT # PRINTS PR00980 TRNASYNTHALA # PROSITE PS50860 AA_TRNA_LIGASE_II_ALA # Pfam PF01411 tRNA-synt_2c # Pfam PF02272 DHHA1 # Pfam PF07973 tRNA_SAD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SYA_ECOLI Alanine--tRNA ligase # RefSeq NP_417177 NC_000913.3 # RefSeq WP_000047184 NZ_LN832404.1 # SIMILARITY Belongs to the class-II aminoacyl-tRNA synthetase family. {ECO 0000305}. # SMART SM00863 tRNA_SAD # SUBCELLULAR LOCATION SYA_ECOLI Cytoplasm. # SUBUNIT Homotetramer. {ECO:0000269|PubMed 7005211}. # SUPFAM SSF101353 SSF101353 # SUPFAM SSF50447 SSF50447 # SUPFAM SSF55186 SSF55186 # TIGRFAMs TIGR00344 alaS # eggNOG COG0013 LUCA # eggNOG ENOG4105CIM Bacteria BLAST swissprot:SYA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SYA_ECOLI BioCyc ECOL316407:JW2667-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2667-MONOMER BioCyc EcoCyc:ALAS-MONOMER http://biocyc.org/getid?id=EcoCyc:ALAS-MONOMER BioCyc MetaCyc:ALAS-MONOMER http://biocyc.org/getid?id=MetaCyc:ALAS-MONOMER COG COG0013 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0013 DIP DIP-9080N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9080N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/jmbi.1996.0103 http://dx.doi.org/10.1006/jmbi.1996.0103 DOI 10.1021/bi00169a019 http://dx.doi.org/10.1021/bi00169a019 DOI 10.1021/bi00242a023 http://dx.doi.org/10.1021/bi00242a023 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature06454 http://dx.doi.org/10.1038/nature06454 DOI 10.1038/nature08612 http://dx.doi.org/10.1038/nature08612 DOI 10.1073/pnas.77.11.6531 http://dx.doi.org/10.1073/pnas.77.11.6531 DOI 10.1073/pnas.91.20.9223 http://dx.doi.org/10.1073/pnas.91.20.9223 DOI 10.1074/jbc.M805943200 http://dx.doi.org/10.1074/jbc.M805943200 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/emboj/cdg065 http://dx.doi.org/10.1093/emboj/cdg065 DOI 10.1126/science.1174343 http://dx.doi.org/10.1126/science.1174343 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1126/science.7025207 http://dx.doi.org/10.1126/science.7025207 EC_number EC:6.1.1.7 http://www.genome.jp/dbget-bin/www_bget?EC:6.1.1.7 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D44453 http://www.ebi.ac.uk/ena/data/view/D44453 EMBL J01581 http://www.ebi.ac.uk/ena/data/view/J01581 EMBL L07596 http://www.ebi.ac.uk/ena/data/view/L07596 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL Z28405 http://www.ebi.ac.uk/ena/data/view/Z28405 ENZYME 6.1.1.7 http://enzyme.expasy.org/EC/6.1.1.7 EchoBASE EB0033 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0033 EcoGene EG10034 http://www.ecogene.org/geneInfo.php?eg_id=EG10034 EnsemblBacteria AAC75739 http://www.ensemblgenomes.org/id/AAC75739 EnsemblBacteria AAC75739 http://www.ensemblgenomes.org/id/AAC75739 EnsemblBacteria BAA16559 http://www.ensemblgenomes.org/id/BAA16559 EnsemblBacteria BAA16559 http://www.ensemblgenomes.org/id/BAA16559 EnsemblBacteria BAA16559 http://www.ensemblgenomes.org/id/BAA16559 EnsemblBacteria b2697 http://www.ensemblgenomes.org/id/b2697 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0000049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000049 GO_function GO:0001141 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001141 GO_function GO:0002161 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002161 GO_function GO:0004813 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004813 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0016597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016597 GO_process GO:0006400 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006400 GO_process GO:0006419 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006419 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 947175 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947175 HAMAP MF_00036_B http://hamap.expasy.org/unirule/MF_00036_B HOGENOM HOG000156964 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000156964&db=HOGENOM6 InParanoid P00957 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00957 IntAct P00957 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00957* IntEnz 6.1.1.7 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.1.1.7 InterPro IPR002318 http://www.ebi.ac.uk/interpro/entry/IPR002318 InterPro IPR003156 http://www.ebi.ac.uk/interpro/entry/IPR003156 InterPro IPR009000 http://www.ebi.ac.uk/interpro/entry/IPR009000 InterPro IPR012947 http://www.ebi.ac.uk/interpro/entry/IPR012947 InterPro IPR018162 http://www.ebi.ac.uk/interpro/entry/IPR018162 InterPro IPR018163 http://www.ebi.ac.uk/interpro/entry/IPR018163 InterPro IPR018164 http://www.ebi.ac.uk/interpro/entry/IPR018164 InterPro IPR018165 http://www.ebi.ac.uk/interpro/entry/IPR018165 InterPro IPR023033 http://www.ebi.ac.uk/interpro/entry/IPR023033 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW2667 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2667 KEGG_Gene eco:b2697 http://www.genome.jp/dbget-bin/www_bget?eco:b2697 KEGG_Orthology KO:K01872 http://www.genome.jp/dbget-bin/www_bget?KO:K01872 KEGG_Pathway ko00970 http://www.genome.jp/kegg-bin/show_pathway?ko00970 KEGG_Reaction rn:R03038 http://www.genome.jp/dbget-bin/www_bget?rn:R03038 MINT MINT-1266342 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1266342 OMA FDFNCPR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FDFNCPR PDB 3HXU http://www.ebi.ac.uk/pdbe-srv/view/entry/3HXU PDB 3HXV http://www.ebi.ac.uk/pdbe-srv/view/entry/3HXV PDB 3HXW http://www.ebi.ac.uk/pdbe-srv/view/entry/3HXW PDB 3HXX http://www.ebi.ac.uk/pdbe-srv/view/entry/3HXX PDB 3HXY http://www.ebi.ac.uk/pdbe-srv/view/entry/3HXY PDB 3HXZ http://www.ebi.ac.uk/pdbe-srv/view/entry/3HXZ PDB 3HY0 http://www.ebi.ac.uk/pdbe-srv/view/entry/3HY0 PDB 3HY1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3HY1 PDBsum 3HXU http://www.ebi.ac.uk/pdbsum/3HXU PDBsum 3HXV http://www.ebi.ac.uk/pdbsum/3HXV PDBsum 3HXW http://www.ebi.ac.uk/pdbsum/3HXW PDBsum 3HXX http://www.ebi.ac.uk/pdbsum/3HXX PDBsum 3HXY http://www.ebi.ac.uk/pdbsum/3HXY PDBsum 3HXZ http://www.ebi.ac.uk/pdbsum/3HXZ PDBsum 3HY0 http://www.ebi.ac.uk/pdbsum/3HY0 PDBsum 3HY1 http://www.ebi.ac.uk/pdbsum/3HY1 PRINTS PR00980 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00980 PROSITE PS50860 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50860 PSORT swissprot:SYA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SYA_ECOLI PSORT-B swissprot:SYA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SYA_ECOLI PSORT2 swissprot:SYA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SYA_ECOLI Pfam PF01411 http://pfam.xfam.org/family/PF01411 Pfam PF02272 http://pfam.xfam.org/family/PF02272 Pfam PF07973 http://pfam.xfam.org/family/PF07973 Phobius swissprot:SYA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SYA_ECOLI PhylomeDB P00957 http://phylomedb.org/?seqid=P00957 ProteinModelPortal P00957 http://www.proteinmodelportal.org/query/uniprot/P00957 PubMed 12554667 http://www.ncbi.nlm.nih.gov/pubmed/12554667 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1712632 http://www.ncbi.nlm.nih.gov/pubmed/1712632 PubMed 18172502 http://www.ncbi.nlm.nih.gov/pubmed/18172502 PubMed 18723508 http://www.ncbi.nlm.nih.gov/pubmed/18723508 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 19661429 http://www.ncbi.nlm.nih.gov/pubmed/19661429 PubMed 20010690 http://www.ncbi.nlm.nih.gov/pubmed/20010690 PubMed 6256345 http://www.ncbi.nlm.nih.gov/pubmed/6256345 PubMed 7005211 http://www.ncbi.nlm.nih.gov/pubmed/7005211 PubMed 7005898 http://www.ncbi.nlm.nih.gov/pubmed/7005898 PubMed 7025207 http://www.ncbi.nlm.nih.gov/pubmed/7025207 PubMed 7524073 http://www.ncbi.nlm.nih.gov/pubmed/7524073 PubMed 8292605 http://www.ncbi.nlm.nih.gov/pubmed/8292605 PubMed 8393005 http://www.ncbi.nlm.nih.gov/pubmed/8393005 PubMed 8604133 http://www.ncbi.nlm.nih.gov/pubmed/8604133 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417177 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417177 RefSeq WP_000047184 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000047184 SMART SM00863 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00863 SMR P00957 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00957 STRING 511145.b2697 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2697&targetmode=cogs STRING COG0013 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0013&targetmode=cogs SUPFAM SSF101353 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF101353 SUPFAM SSF50447 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50447 SUPFAM SSF55186 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55186 SWISS-2DPAGE P00957 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P00957 TIGRFAMs TIGR00344 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00344 UniProtKB SYA_ECOLI http://www.uniprot.org/uniprot/SYA_ECOLI UniProtKB-AC P00957 http://www.uniprot.org/uniprot/P00957 charge swissprot:SYA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SYA_ECOLI eggNOG COG0013 http://eggnogapi.embl.de/nog_data/html/tree/COG0013 eggNOG ENOG4105CIM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CIM epestfind swissprot:SYA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SYA_ECOLI garnier swissprot:SYA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SYA_ECOLI helixturnhelix swissprot:SYA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SYA_ECOLI hmoment swissprot:SYA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SYA_ECOLI iep swissprot:SYA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SYA_ECOLI inforesidue swissprot:SYA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SYA_ECOLI octanol swissprot:SYA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SYA_ECOLI pepcoil swissprot:SYA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SYA_ECOLI pepdigest swissprot:SYA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SYA_ECOLI pepinfo swissprot:SYA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SYA_ECOLI pepnet swissprot:SYA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SYA_ECOLI pepstats swissprot:SYA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SYA_ECOLI pepwheel swissprot:SYA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SYA_ECOLI pepwindow swissprot:SYA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SYA_ECOLI sigcleave swissprot:SYA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SYA_ECOLI ## Database ID URL or Descriptions # AltName HEMN_ECOLI Coproporphyrinogen III dehydrogenase # BRENDA 1.3.99.22 2026 # BioGrid 4262627 11 # CATALYTIC ACTIVITY Coproporphyrinogen III + 2 S-adenosyl-L- methionine = protoporphyrinogen IX + 2 CO(2) + 2 L-methionine + 2 5'-deoxyadenosine. {ECO:0000269|PubMed 12114526}. # COFACTOR HEMN_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000269|PubMed 12114526, ECO 0000269|PubMed 14633981}; Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. {ECO 0000269|PubMed 12114526, ECO 0000269|PubMed 14633981}; # ENZYME REGULATION Inhibited by EDTA. {ECO:0000269|PubMed 12114526}. # EcoGene EG11836 hemN # FUNCTION HEMN_ECOLI Involved in the heme biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen III to yield the vinyl groups in protoporphyrinogen IX. It can use NAD or NADP, but NAD is preferred. {ECO 0000269|PubMed 12114526, ECO 0000269|PubMed 7768836}. # GO_component GO:0005737 cytoplasm; IDA:UniProtKB. # GO_function GO:0004109 coproporphyrinogen oxidase activity; IEA:InterPro. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IDA:EcoCyc. # GO_function GO:0051989 coproporphyrinogen dehydrogenase activity; IDA:EcoCyc. # GO_process GO:0006782 protoporphyrinogen IX biosynthetic process; IDA:UniProtKB. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 1.10.10.10 -; 1. # Gene3D 3.80.30.20 -; 1. # IntAct P32131 7 # InterPro IPR004558 Coprogen_oxidase_HemN # InterPro IPR006638 Elp3/MiaB/NifB # InterPro IPR007197 rSAM # InterPro IPR010723 HemN_C # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR023404 rSAM_horseshoe # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00860 Porphyrin and chlorophyll metabolism # MISCELLANEOUS The structure carries two S-adenosyl-L-methionine binding sites with only one binding to iron-cluster. {ECO:0000305|PubMed 14633981}. # Organism HEMN_ECOLI Escherichia coli (strain K12) # PATHWAY Porphyrin-containing compound metabolism; protoporphyrin- IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (AdoMet route) step 1/1. # PATRIC 32123235 VBIEscCol129921_3978 # PDB 1OLT X-ray; 2.07 A; A=1-457 # PIRSF PIRSF000167 HemN # Pfam PF04055 Radical_SAM # Pfam PF06969 HemN_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HEMN_ECOLI Oxygen-independent coproporphyrinogen III oxidase # RefSeq NP_418303 NC_000913.3 # RefSeq WP_000116090 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB03001.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the anaerobic coproporphyrinogen-III oxidase family. {ECO 0000305}. # SMART SM00729 Elp3 # SUBCELLULAR LOCATION HEMN_ECOLI Cytoplasm {ECO 0000269|PubMed 12114526}. # SUBUNIT HEMN_ECOLI Monomer. {ECO 0000269|PubMed 12114526, ECO 0000269|PubMed 14633981}. # TIGRFAMs TIGR00538 hemN # UniPathway UPA00251 UER00323 # eggNOG COG0635 LUCA # eggNOG ENOG4105D4P Bacteria BLAST swissprot:HEMN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HEMN_ECOLI BioCyc ECOL316407:JW3838-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3838-MONOMER BioCyc EcoCyc:HEMN-MONOMER http://biocyc.org/getid?id=EcoCyc:HEMN-MONOMER BioCyc MetaCyc:HEMN-MONOMER http://biocyc.org/getid?id=MetaCyc:HEMN-MONOMER COG COG0635 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0635 DIP DIP-9887N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9887N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M205247200 http://dx.doi.org/10.1074/jbc.M205247200 DOI 10.1074/jbc.M501275200 http://dx.doi.org/10.1074/jbc.M501275200 DOI 10.1074/jbc.M512628200 http://dx.doi.org/10.1074/jbc.M512628200 DOI 10.1093/emboj/cdg598 http://dx.doi.org/10.1093/emboj/cdg598 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.3.98.3 {ECO:0000269|PubMed:12114526} http://www.genome.jp/dbget-bin/www_bget?EC:1.3.98.3 {ECO:0000269|PubMed:12114526} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D16509 http://www.ebi.ac.uk/ena/data/view/D16509 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X82073 http://www.ebi.ac.uk/ena/data/view/X82073 ENZYME 1.3.98.3 {ECO:0000269|PubMed:12114526} http://enzyme.expasy.org/EC/1.3.98.3 {ECO:0000269|PubMed:12114526} EchoBASE EB1782 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1782 EcoGene EG11836 http://www.ecogene.org/geneInfo.php?eg_id=EG11836 EnsemblBacteria AAC76864 http://www.ensemblgenomes.org/id/AAC76864 EnsemblBacteria AAC76864 http://www.ensemblgenomes.org/id/AAC76864 EnsemblBacteria BAE77442 http://www.ensemblgenomes.org/id/BAE77442 EnsemblBacteria BAE77442 http://www.ensemblgenomes.org/id/BAE77442 EnsemblBacteria BAE77442 http://www.ensemblgenomes.org/id/BAE77442 EnsemblBacteria b3867 http://www.ensemblgenomes.org/id/b3867 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004109 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004109 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_function GO:0051989 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051989 GO_process GO:0006782 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006782 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 3.80.30.20 http://www.cathdb.info/version/latest/superfamily/3.80.30.20 GeneID 948362 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948362 HOGENOM HOG000257214 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000257214&db=HOGENOM6 InParanoid P32131 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32131 IntAct P32131 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32131* IntEnz 1.3.98.3 {ECO:0000269|PubMed:12114526} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.3.98.3 {ECO:0000269|PubMed:12114526} InterPro IPR004558 http://www.ebi.ac.uk/interpro/entry/IPR004558 InterPro IPR006638 http://www.ebi.ac.uk/interpro/entry/IPR006638 InterPro IPR007197 http://www.ebi.ac.uk/interpro/entry/IPR007197 InterPro IPR010723 http://www.ebi.ac.uk/interpro/entry/IPR010723 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR023404 http://www.ebi.ac.uk/interpro/entry/IPR023404 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3838 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3838 KEGG_Gene eco:b3867 http://www.genome.jp/dbget-bin/www_bget?eco:b3867 KEGG_Orthology KO:K02495 http://www.genome.jp/dbget-bin/www_bget?KO:K02495 KEGG_Pathway ko00860 http://www.genome.jp/kegg-bin/show_pathway?ko00860 KEGG_Reaction rn:R06895 http://www.genome.jp/dbget-bin/www_bget?rn:R06895 OMA CEIDPRH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CEIDPRH PDB 1OLT http://www.ebi.ac.uk/pdbe-srv/view/entry/1OLT PDBsum 1OLT http://www.ebi.ac.uk/pdbsum/1OLT PSORT swissprot:HEMN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HEMN_ECOLI PSORT-B swissprot:HEMN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HEMN_ECOLI PSORT2 swissprot:HEMN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HEMN_ECOLI Pfam PF04055 http://pfam.xfam.org/family/PF04055 Pfam PF06969 http://pfam.xfam.org/family/PF06969 Phobius swissprot:HEMN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HEMN_ECOLI PhylomeDB P32131 http://phylomedb.org/?seqid=P32131 ProteinModelPortal P32131 http://www.proteinmodelportal.org/query/uniprot/P32131 PubMed 12114526 http://www.ncbi.nlm.nih.gov/pubmed/12114526 PubMed 14633981 http://www.ncbi.nlm.nih.gov/pubmed/14633981 PubMed 15967800 http://www.ncbi.nlm.nih.gov/pubmed/15967800 PubMed 16606627 http://www.ncbi.nlm.nih.gov/pubmed/16606627 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7768836 http://www.ncbi.nlm.nih.gov/pubmed/7768836 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418303 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418303 RefSeq WP_000116090 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000116090 SMART SM00729 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00729 SMR P32131 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32131 STRING 511145.b3867 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3867&targetmode=cogs STRING COG0635 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0635&targetmode=cogs TIGRFAMs TIGR00538 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00538 UniProtKB HEMN_ECOLI http://www.uniprot.org/uniprot/HEMN_ECOLI UniProtKB-AC P32131 http://www.uniprot.org/uniprot/P32131 charge swissprot:HEMN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HEMN_ECOLI eggNOG COG0635 http://eggnogapi.embl.de/nog_data/html/tree/COG0635 eggNOG ENOG4105D4P http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D4P epestfind swissprot:HEMN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HEMN_ECOLI garnier swissprot:HEMN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HEMN_ECOLI helixturnhelix swissprot:HEMN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HEMN_ECOLI hmoment swissprot:HEMN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HEMN_ECOLI iep swissprot:HEMN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HEMN_ECOLI inforesidue swissprot:HEMN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HEMN_ECOLI octanol swissprot:HEMN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HEMN_ECOLI pepcoil swissprot:HEMN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HEMN_ECOLI pepdigest swissprot:HEMN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HEMN_ECOLI pepinfo swissprot:HEMN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HEMN_ECOLI pepnet swissprot:HEMN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HEMN_ECOLI pepstats swissprot:HEMN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HEMN_ECOLI pepwheel swissprot:HEMN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HEMN_ECOLI pepwindow swissprot:HEMN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HEMN_ECOLI sigcleave swissprot:HEMN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HEMN_ECOLI ## Database ID URL or Descriptions # AltName INSJ_ECOLI ORFA # EcoGene EG40010 insJ # GO_function GO:0043565 sequence-specific DNA binding; IEA:InterPro. # GOslim_function GO:0003677 DNA binding # Gene3D 1.10.10.60 -; 2. # InterPro IPR009057 Homeodomain-like # InterPro IPR010921 Trp_repressor/repl_initiator # Organism INSJ_ECOLI Escherichia coli (strain K12) # PATRIC 32122588 VBIEscCol129921_3671 # PIR S47778 S47778 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSJ_ECOLI Insertion element IS150 uncharacterized 19.7 kDa protein # RefSeq NP_065293 NC_002525.1 # RefSeq NP_418014 NC_000913.3 # RefSeq WP_000042691 NZ_LN832404.1 # SIMILARITY Belongs to the IS150/IS1296 orfA family. {ECO 0000305}. # SUPFAM SSF48295 SSF48295; 2 # eggNOG ENOG410698F Bacteria # eggNOG ENOG4111QWX LUCA BLAST swissprot:INSJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSJ_ECOLI BioCyc ECOL316407:JW3527-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3527-MONOMER BioCyc EcoCyc:G7776-MONOMER http://biocyc.org/getid?id=EcoCyc:G7776-MONOMER COG COG2963 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2963 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/16.14.6789 http://dx.doi.org/10.1093/nar/16.14.6789 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X07037 http://www.ebi.ac.uk/ena/data/view/X07037 EchoBASE EB4746 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4746 EcoGene EG40010 http://www.ecogene.org/geneInfo.php?eg_id=EG40010 EnsemblBacteria AAC76581 http://www.ensemblgenomes.org/id/AAC76581 EnsemblBacteria AAC76581 http://www.ensemblgenomes.org/id/AAC76581 EnsemblBacteria BAE77737 http://www.ensemblgenomes.org/id/BAE77737 EnsemblBacteria BAE77737 http://www.ensemblgenomes.org/id/BAE77737 EnsemblBacteria BAE77737 http://www.ensemblgenomes.org/id/BAE77737 EnsemblBacteria b3557 http://www.ensemblgenomes.org/id/b3557 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 GeneID 1238726 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1238726 GeneID 948082 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948082 HOGENOM HOG000266651 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000266651&db=HOGENOM6 InParanoid P19768 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P19768 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR010921 http://www.ebi.ac.uk/interpro/entry/IPR010921 KEGG_Gene ecj:JW3527 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3527 KEGG_Gene eco:b3557 http://www.genome.jp/dbget-bin/www_bget?eco:b3557 KEGG_Orthology KO:K07483 http://www.genome.jp/dbget-bin/www_bget?KO:K07483 OMA HYFATDE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HYFATDE PSORT swissprot:INSJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSJ_ECOLI PSORT-B swissprot:INSJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSJ_ECOLI PSORT2 swissprot:INSJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSJ_ECOLI Phobius swissprot:INSJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSJ_ECOLI PhylomeDB P19768 http://phylomedb.org/?seqid=P19768 ProteinModelPortal P19768 http://www.proteinmodelportal.org/query/uniprot/P19768 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2541046 http://www.ncbi.nlm.nih.gov/pubmed/2541046 PubMed 2841644 http://www.ncbi.nlm.nih.gov/pubmed/2841644 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_065293 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_065293 RefSeq NP_418014 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418014 RefSeq WP_000042691 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000042691 SMR P19768 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P19768 STRING 511145.b3557 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3557&targetmode=cogs STRING COG2963 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2963&targetmode=cogs SUPFAM SSF48295 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48295 UniProtKB INSJ_ECOLI http://www.uniprot.org/uniprot/INSJ_ECOLI UniProtKB-AC P19768 http://www.uniprot.org/uniprot/P19768 charge swissprot:INSJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSJ_ECOLI eggNOG ENOG410698F http://eggnogapi.embl.de/nog_data/html/tree/ENOG410698F eggNOG ENOG4111QWX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111QWX epestfind swissprot:INSJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSJ_ECOLI garnier swissprot:INSJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSJ_ECOLI helixturnhelix swissprot:INSJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSJ_ECOLI hmoment swissprot:INSJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSJ_ECOLI iep swissprot:INSJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSJ_ECOLI inforesidue swissprot:INSJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSJ_ECOLI octanol swissprot:INSJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSJ_ECOLI pepcoil swissprot:INSJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSJ_ECOLI pepdigest swissprot:INSJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSJ_ECOLI pepinfo swissprot:INSJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSJ_ECOLI pepnet swissprot:INSJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSJ_ECOLI pepstats swissprot:INSJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSJ_ECOLI pepwheel swissprot:INSJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSJ_ECOLI pepwindow swissprot:INSJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSJ_ECOLI sigcleave swissprot:INSJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSJ_ECOLI ## Database ID URL or Descriptions # AltName PGPB_ECOLI Diacylglycerol pyrophosphate phosphatase # AltName PGPB_ECOLI Phosphatidate phosphatase # AltName PGPB_ECOLI Undecaprenyl pyrophosphate phosphatase # AltName PGPB_ECOLI Undecaprenyl-diphosphatase # BIOPHYSICOCHEMICAL PROPERTIES PGPB_ECOLI Kinetic parameters KM=530 uM for undecaprenyl pyrophosphate {ECO 0000269|PubMed 18411271, ECO 0000269|PubMed 8940025}; KM=96 uM for farnesyl pyrophosphate {ECO 0000269|PubMed 18411271, ECO 0000269|PubMed 8940025}; KM=80 uM for diacylglycerol pyrophosphate {ECO 0000269|PubMed 18411271, ECO 0000269|PubMed 8940025}; KM=1700 uM for phosphatidate {ECO 0000269|PubMed 18411271, ECO 0000269|PubMed 8940025}; Vmax=2167 nmol/min/mg enzyme with diacylglycerol pyrophosphate as substrate {ECO 0000269|PubMed 18411271, ECO 0000269|PubMed 8940025}; Vmax=313 nmol/min/mg enzyme with phosphatidate as substrate {ECO 0000269|PubMed 18411271, ECO 0000269|PubMed 8940025}; pH dependence Optimum pH is 6.5 for DGPP phosphatase activity and 6.5-7.5 for undecaprenyl pyrophosphate phosphatase activity. {ECO 0000269|PubMed 18411271, ECO 0000269|PubMed 8940025}; # BioGrid 4262195 212 # CATALYTIC ACTIVITY PGPB_ECOLI 1,2-diacyl-sn-glycerol 3-diphosphate + H(2)O = 1,2-diacyl-sn-glycerol 3-phosphate + phosphate. # CATALYTIC ACTIVITY PGPB_ECOLI A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate. # CATALYTIC ACTIVITY PGPB_ECOLI Ditrans,octacis-undecaprenyl diphosphate + H(2)O = ditrans,octacis-undecaprenyl phosphate + phosphate. # CATALYTIC ACTIVITY PGPB_ECOLI Phosphatidylglycerophosphate + H(2)O = phosphatidylglycerol + phosphate. # ENZYME REGULATION PGPB_ECOLI Inhibited by Mn(2+) ions. # EcoGene EG10705 pgpB # FUNCTION PGPB_ECOLI Catalyzes the dephosphorylation of diacylglycerol diphosphate (DGPP) to phosphatidate (PA) and the subsequent dephosphorylation of PA to diacylglycerol (DAG). Also has undecaprenyl pyrophosphate phosphatase activity, required for the biosynthesis of the lipid carrier undecaprenyl phosphate. Can also use lysophosphatidic acid (LPA) and phosphatidylglycerophosphate as substrates. The pattern of activities varies according to subcellular location, PGP phosphatase activity is higher in the cytoplasmic membrane, whereas PA and LPA phosphatase activities are higher in the outer membrane. Activity is independent of a divalent cation ion and insensitive to inhibition by N- ethylmaleimide. {ECO 0000269|PubMed 15778224, ECO 0000269|PubMed 18411271, ECO 0000269|PubMed 21148555, ECO 0000269|PubMed 8940025}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0009279 cell outer membrane; IMP:EcoCyc. # GO_function GO:0000810 diacylglycerol diphosphate phosphatase activity; IEA:UniProtKB-EC. # GO_function GO:0008195 phosphatidate phosphatase activity; IEA:UniProtKB-EC. # GO_function GO:0008962 phosphatidylglycerophosphatase activity; IMP:EcoCyc. # GO_function GO:0050380 undecaprenyl-diphosphatase activity; IDA:EcoCyc. # GO_process GO:0006655 phosphatidylglycerol biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0009252 peptidoglycan biosynthetic process; IMP:EcoCyc. # GO_process GO:0009395 phospholipid catabolic process; IEA:UniProtKB-KW. # GO_process GO:0046474 glycerophospholipid biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016791 phosphatase activity # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 1.20.144.10 -; 2. # InterPro IPR000326 P_Acid_Pase_2/haloperoxidase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00564 Glycerophospholipid metabolism # MASS SPECTROMETRY Mass=30151; Method=MALDI; Range=2-254; Note=Reported mass includes mass of a C-terminal His6 tag.; Evidence={ECO:0000269|PubMed 18411271}; # Organism PGPB_ECOLI Escherichia coli (strain K12) # PATHWAY Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol step 2/2. # PATRIC 32117818 VBIEscCol129921_1329 # PDB 5JWY X-ray; 3.20 A; A=1-254 # PIR A30193 PAECGB # PTM PGPB_ECOLI The N-terminus is blocked. # Pfam PF01569 PAP2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PGPB_ECOLI Phosphatidylglycerophosphatase B # RefSeq NP_415794 NC_000913.3 # RefSeq WP_001256538 NZ_LN832404.1 # SIMILARITY Belongs to the PA-phosphatase related phosphoesterase family. {ECO 0000305}. # SMART SM00014 acidPPc # SUBCELLULAR LOCATION PGPB_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. Cell outer membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # SUPFAM SSF48317 SSF48317; 2 # UniPathway UPA00084 UER00504 # eggNOG COG0671 LUCA # eggNOG ENOG4105EYK Bacteria BLAST swissprot:PGPB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PGPB_ECOLI BioCyc ECOL316407:JW1270-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1270-MONOMER BioCyc EcoCyc:PGPPHOSPHAB-MONOMER http://biocyc.org/getid?id=EcoCyc:PGPPHOSPHAB-MONOMER BioCyc MetaCyc:PGPPHOSPHAB-MONOMER http://biocyc.org/getid?id=MetaCyc:PGPPHOSPHAB-MONOMER COG COG0671 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0671 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.271.48.30548 http://dx.doi.org/10.1074/jbc.271.48.30548 DOI 10.1074/jbc.M110.199265 http://dx.doi.org/10.1074/jbc.M110.199265 DOI 10.1074/jbc.M412277200 http://dx.doi.org/10.1074/jbc.M412277200 DOI 10.1074/jbc.M800394200 http://dx.doi.org/10.1074/jbc.M800394200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.3.27 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.27 EC_number EC:3.1.3.4 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.4 EC_number EC:3.1.3.81 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.81 EC_number EC:3.6.1.27 http://www.genome.jp/dbget-bin/www_bget?EC:3.6.1.27 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M23628 http://www.ebi.ac.uk/ena/data/view/M23628 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.3.27 http://enzyme.expasy.org/EC/3.1.3.27 ENZYME 3.1.3.4 http://enzyme.expasy.org/EC/3.1.3.4 ENZYME 3.1.3.81 http://enzyme.expasy.org/EC/3.1.3.81 ENZYME 3.6.1.27 http://enzyme.expasy.org/EC/3.6.1.27 EchoBASE EB0699 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0699 EcoGene EG10705 http://www.ecogene.org/geneInfo.php?eg_id=EG10705 EnsemblBacteria AAC74360 http://www.ensemblgenomes.org/id/AAC74360 EnsemblBacteria AAC74360 http://www.ensemblgenomes.org/id/AAC74360 EnsemblBacteria BAA14832 http://www.ensemblgenomes.org/id/BAA14832 EnsemblBacteria BAA14832 http://www.ensemblgenomes.org/id/BAA14832 EnsemblBacteria BAA14832 http://www.ensemblgenomes.org/id/BAA14832 EnsemblBacteria b1278 http://www.ensemblgenomes.org/id/b1278 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_function GO:0000810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000810 GO_function GO:0008195 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008195 GO_function GO:0008962 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008962 GO_function GO:0050380 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050380 GO_process GO:0006655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006655 GO_process GO:0009252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009252 GO_process GO:0009395 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009395 GO_process GO:0046474 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046474 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 1.20.144.10 http://www.cathdb.info/version/latest/superfamily/1.20.144.10 GeneID 945863 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945863 HOGENOM HOG000286191 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000286191&db=HOGENOM6 InParanoid P0A924 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A924 IntAct P0A924 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A924* IntEnz 3.1.3.27 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.27 IntEnz 3.1.3.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.4 IntEnz 3.1.3.81 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.81 IntEnz 3.6.1.27 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.1.27 InterPro IPR000326 http://www.ebi.ac.uk/interpro/entry/IPR000326 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1270 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1270 KEGG_Gene eco:b1278 http://www.genome.jp/dbget-bin/www_bget?eco:b1278 KEGG_Orthology KO:K01096 http://www.genome.jp/dbget-bin/www_bget?KO:K01096 KEGG_Pathway ko00564 http://www.genome.jp/kegg-bin/show_pathway?ko00564 KEGG_Reaction rn:R02029 http://www.genome.jp/dbget-bin/www_bget?rn:R02029 OMA AQRLCGP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AQRLCGP PDB 5JWY http://www.ebi.ac.uk/pdbe-srv/view/entry/5JWY PDBsum 5JWY http://www.ebi.ac.uk/pdbsum/5JWY PSORT swissprot:PGPB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PGPB_ECOLI PSORT-B swissprot:PGPB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PGPB_ECOLI PSORT2 swissprot:PGPB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PGPB_ECOLI Pfam PF01569 http://pfam.xfam.org/family/PF01569 Phobius swissprot:PGPB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PGPB_ECOLI ProteinModelPortal P0A924 http://www.proteinmodelportal.org/query/uniprot/P0A924 PubMed 15778224 http://www.ncbi.nlm.nih.gov/pubmed/15778224 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18411271 http://www.ncbi.nlm.nih.gov/pubmed/18411271 PubMed 21148555 http://www.ncbi.nlm.nih.gov/pubmed/21148555 PubMed 2846511 http://www.ncbi.nlm.nih.gov/pubmed/2846511 PubMed 8940025 http://www.ncbi.nlm.nih.gov/pubmed/8940025 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415794 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415794 RefSeq WP_001256538 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001256538 SMART SM00014 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00014 SMR P0A924 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A924 STRING 511145.b1278 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1278&targetmode=cogs STRING COG0671 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0671&targetmode=cogs SUPFAM SSF48317 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48317 UniProtKB PGPB_ECOLI http://www.uniprot.org/uniprot/PGPB_ECOLI UniProtKB-AC P0A924 http://www.uniprot.org/uniprot/P0A924 charge swissprot:PGPB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PGPB_ECOLI eggNOG COG0671 http://eggnogapi.embl.de/nog_data/html/tree/COG0671 eggNOG ENOG4105EYK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EYK epestfind swissprot:PGPB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PGPB_ECOLI garnier swissprot:PGPB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PGPB_ECOLI helixturnhelix swissprot:PGPB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PGPB_ECOLI hmoment swissprot:PGPB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PGPB_ECOLI iep swissprot:PGPB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PGPB_ECOLI inforesidue swissprot:PGPB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PGPB_ECOLI octanol swissprot:PGPB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PGPB_ECOLI pepcoil swissprot:PGPB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PGPB_ECOLI pepdigest swissprot:PGPB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PGPB_ECOLI pepinfo swissprot:PGPB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PGPB_ECOLI pepnet swissprot:PGPB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PGPB_ECOLI pepstats swissprot:PGPB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PGPB_ECOLI pepwheel swissprot:PGPB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PGPB_ECOLI pepwindow swissprot:PGPB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PGPB_ECOLI sigcleave swissprot:PGPB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PGPB_ECOLI ## Database ID URL or Descriptions # BioGrid 4262807 13 # EcoGene EG13589 yahE # IntAct P77297 6 # InterPro IPR021530 DUF2877 # Organism YAHE_ECOLI Escherichia coli (strain K12) # PATRIC 32115767 VBIEscCol129921_0326 # PIR G64758 G64758 # Pfam PF11392 DUF2877 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAHE_ECOLI Uncharacterized protein YahE # RefSeq NP_414853 NC_000913.3 # RefSeq WP_001310582 NZ_LN832404.1 # eggNOG ENOG4105N16 Bacteria # eggNOG ENOG4111W16 LUCA BLAST swissprot:YAHE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAHE_ECOLI BioCyc ECOL316407:JW0311-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0311-MONOMER BioCyc EcoCyc:G6184-MONOMER http://biocyc.org/getid?id=EcoCyc:G6184-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB3359 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3359 EcoGene EG13589 http://www.ecogene.org/geneInfo.php?eg_id=EG13589 EnsemblBacteria AAC73422 http://www.ensemblgenomes.org/id/AAC73422 EnsemblBacteria AAC73422 http://www.ensemblgenomes.org/id/AAC73422 EnsemblBacteria BAE76102 http://www.ensemblgenomes.org/id/BAE76102 EnsemblBacteria BAE76102 http://www.ensemblgenomes.org/id/BAE76102 EnsemblBacteria BAE76102 http://www.ensemblgenomes.org/id/BAE76102 EnsemblBacteria b0319 http://www.ensemblgenomes.org/id/b0319 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947134 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947134 HOGENOM HOG000117356 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117356&db=HOGENOM6 IntAct P77297 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77297* InterPro IPR021530 http://www.ebi.ac.uk/interpro/entry/IPR021530 KEGG_Gene ecj:JW0311 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0311 KEGG_Gene eco:b0319 http://www.genome.jp/dbget-bin/www_bget?eco:b0319 OMA THFDGLF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=THFDGLF PSORT swissprot:YAHE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAHE_ECOLI PSORT-B swissprot:YAHE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAHE_ECOLI PSORT2 swissprot:YAHE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAHE_ECOLI Pfam PF11392 http://pfam.xfam.org/family/PF11392 Phobius swissprot:YAHE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAHE_ECOLI ProteinModelPortal P77297 http://www.proteinmodelportal.org/query/uniprot/P77297 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414853 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414853 RefSeq WP_001310582 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001310582 STRING 511145.b0319 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0319&targetmode=cogs UniProtKB YAHE_ECOLI http://www.uniprot.org/uniprot/YAHE_ECOLI UniProtKB-AC P77297 http://www.uniprot.org/uniprot/P77297 charge swissprot:YAHE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAHE_ECOLI eggNOG ENOG4105N16 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105N16 eggNOG ENOG4111W16 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111W16 epestfind swissprot:YAHE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAHE_ECOLI garnier swissprot:YAHE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAHE_ECOLI helixturnhelix swissprot:YAHE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAHE_ECOLI hmoment swissprot:YAHE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAHE_ECOLI iep swissprot:YAHE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAHE_ECOLI inforesidue swissprot:YAHE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAHE_ECOLI octanol swissprot:YAHE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAHE_ECOLI pepcoil swissprot:YAHE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAHE_ECOLI pepdigest swissprot:YAHE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAHE_ECOLI pepinfo swissprot:YAHE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAHE_ECOLI pepnet swissprot:YAHE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAHE_ECOLI pepstats swissprot:YAHE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAHE_ECOLI pepwheel swissprot:YAHE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAHE_ECOLI pepwindow swissprot:YAHE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAHE_ECOLI sigcleave swissprot:YAHE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAHE_ECOLI ## Database ID URL or Descriptions # AltName HOKD_ECOLI Protein RelF # BioGrid 4260242 117 # EcoGene EG11130 hokD # FUNCTION HOKD_ECOLI Overexpression of relF results in collapse of the transmembrane potential and concomitant arrest of oxygen consumption. # FUNCTION HOKD_ECOLI When overexpressed kills the cells from the inside by interfering with a vital function in the cell membrane. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR000021 Hok/gef_toxin # InterPro IPR018084 Hok/gef_toxin_CS # Organism HOKD_ECOLI Escherichia coli (strain K12) # PATRIC 32118430 VBIEscCol129921_1635 # PIR E64911 QQECR5 # PRINTS PR00281 HOKGEFTOXIC # PROSITE PS00556 HOK_GEF # Pfam PF01848 HOK_GEF # ProDom PD005979 Hok/gef_toxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HOKD_ECOLI Protein HokD # RefSeq NP_416080 NC_000913.3 # RefSeq WP_000813254 NZ_LN832404.1 # SIMILARITY Belongs to the hok/gef family. {ECO 0000305}. # SUBCELLULAR LOCATION HOKD_ECOLI Cell membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. BLAST swissprot:HOKD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HOKD_ECOLI BioCyc ECOL316407:JW1554-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1554-MONOMER BioCyc EcoCyc:EG11130-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11130-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1999.01431.x http://dx.doi.org/10.1046/j.1365-2958.1999.01431.x DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X02405 http://www.ebi.ac.uk/ena/data/view/X02405 EchoBASE EB1120 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1120 EcoGene EG11130 http://www.ecogene.org/geneInfo.php?eg_id=EG11130 EnsemblBacteria AAC74635 http://www.ensemblgenomes.org/id/AAC74635 EnsemblBacteria AAC74635 http://www.ensemblgenomes.org/id/AAC74635 EnsemblBacteria BAA15261 http://www.ensemblgenomes.org/id/BAA15261 EnsemblBacteria BAA15261 http://www.ensemblgenomes.org/id/BAA15261 EnsemblBacteria BAA15261 http://www.ensemblgenomes.org/id/BAA15261 EnsemblBacteria b1562 http://www.ensemblgenomes.org/id/b1562 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 948616 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948616 HOGENOM HOG000041219 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000041219&db=HOGENOM6 InterPro IPR000021 http://www.ebi.ac.uk/interpro/entry/IPR000021 InterPro IPR018084 http://www.ebi.ac.uk/interpro/entry/IPR018084 KEGG_Gene ecj:JW1554 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1554 KEGG_Gene eco:b1562 http://www.genome.jp/dbget-bin/www_bget?eco:b1562 OMA CEVRIRS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CEVRIRS PRINTS PR00281 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00281 PROSITE PS00556 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00556 PSORT swissprot:HOKD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HOKD_ECOLI PSORT-B swissprot:HOKD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HOKD_ECOLI PSORT2 swissprot:HOKD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HOKD_ECOLI Pfam PF01848 http://pfam.xfam.org/family/PF01848 Phobius swissprot:HOKD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HOKD_ECOLI PhylomeDB P0ACG6 http://phylomedb.org/?seqid=P0ACG6 ProteinModelPortal P0ACG6 http://www.proteinmodelportal.org/query/uniprot/P0ACG6 PubMed 10361310 http://www.ncbi.nlm.nih.gov/pubmed/10361310 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2990907 http://www.ncbi.nlm.nih.gov/pubmed/2990907 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416080 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416080 RefSeq WP_000813254 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000813254 STRING 511145.b1562 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1562&targetmode=cogs UniProtKB HOKD_ECOLI http://www.uniprot.org/uniprot/HOKD_ECOLI UniProtKB-AC P0ACG6 http://www.uniprot.org/uniprot/P0ACG6 charge swissprot:HOKD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HOKD_ECOLI epestfind swissprot:HOKD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HOKD_ECOLI garnier swissprot:HOKD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HOKD_ECOLI helixturnhelix swissprot:HOKD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HOKD_ECOLI hmoment swissprot:HOKD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HOKD_ECOLI iep swissprot:HOKD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HOKD_ECOLI inforesidue swissprot:HOKD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HOKD_ECOLI octanol swissprot:HOKD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HOKD_ECOLI pepcoil swissprot:HOKD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HOKD_ECOLI pepdigest swissprot:HOKD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HOKD_ECOLI pepinfo swissprot:HOKD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HOKD_ECOLI pepnet swissprot:HOKD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HOKD_ECOLI pepstats swissprot:HOKD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HOKD_ECOLI pepwheel swissprot:HOKD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HOKD_ECOLI pepwindow swissprot:HOKD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HOKD_ECOLI sigcleave swissprot:HOKD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HOKD_ECOLI ## Database ID URL or Descriptions # EcoGene EG14393 yciY # Organism YCIY_ECOLI Escherichia coli (strain K12) # Proteomes UP000000625 Chromosome # RecName YCIY_ECOLI Uncharacterized protein YciY # RefSeq YP_001165316 NC_000913.3 # SIMILARITY Belongs to the YciY family. {ECO 0000305}. # eggNOG ENOG410694M Bacteria # eggNOG ENOG410Y1RZ LUCA BLAST swissprot:YCIY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCIY_ECOLI BioCyc EcoCyc:MONOMER0-765 http://biocyc.org/getid?id=EcoCyc:MONOMER0-765 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14393 http://www.ecogene.org/geneInfo.php?eg_id=EG14393 EnsemblBacteria ABP93442 http://www.ensemblgenomes.org/id/ABP93442 EnsemblBacteria ABP93442 http://www.ensemblgenomes.org/id/ABP93442 EnsemblBacteria b4595 http://www.ensemblgenomes.org/id/b4595 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 5061502 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5061502 HOGENOM HOG000267954 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267954&db=HOGENOM6 KEGG_Gene eco:b4595 http://www.genome.jp/dbget-bin/www_bget?eco:b4595 OMA IRIHAIR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IRIHAIR PSORT swissprot:YCIY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCIY_ECOLI PSORT-B swissprot:YCIY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCIY_ECOLI PSORT2 swissprot:YCIY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCIY_ECOLI Phobius swissprot:YCIY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCIY_ECOLI ProteinModelPortal A5A613 http://www.proteinmodelportal.org/query/uniprot/A5A613 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq YP_001165316 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001165316 STRING 511145.b4595 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4595&targetmode=cogs UniProtKB YCIY_ECOLI http://www.uniprot.org/uniprot/YCIY_ECOLI UniProtKB-AC A5A613 http://www.uniprot.org/uniprot/A5A613 charge swissprot:YCIY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCIY_ECOLI eggNOG ENOG410694M http://eggnogapi.embl.de/nog_data/html/tree/ENOG410694M eggNOG ENOG410Y1RZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y1RZ epestfind swissprot:YCIY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCIY_ECOLI garnier swissprot:YCIY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCIY_ECOLI helixturnhelix swissprot:YCIY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCIY_ECOLI hmoment swissprot:YCIY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCIY_ECOLI iep swissprot:YCIY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCIY_ECOLI inforesidue swissprot:YCIY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCIY_ECOLI octanol swissprot:YCIY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCIY_ECOLI pepcoil swissprot:YCIY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCIY_ECOLI pepdigest swissprot:YCIY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCIY_ECOLI pepinfo swissprot:YCIY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCIY_ECOLI pepnet swissprot:YCIY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCIY_ECOLI pepstats swissprot:YCIY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCIY_ECOLI pepwheel swissprot:YCIY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCIY_ECOLI pepwindow swissprot:YCIY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCIY_ECOLI sigcleave swissprot:YCIY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCIY_ECOLI ## Database ID URL or Descriptions # BioGrid 4262962 62 # EcoGene EG12363 ygiL # GO_component GO:0009289 pilus; IEA:UniProtKB-SubCell. # GO_process GO:0007155 cell adhesion; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0007155 cell adhesion # Gene3D 2.60.40.1090 -; 1. # IntAct P39834 25 # InterPro IPR000259 Adhesion_dom_fimbrial # InterPro IPR008966 Adhesion_dom # Organism YGIL_ECOLI Escherichia coli (strain K12) # PATRIC 32121498 VBIEscCol129921_3136 # PIR A65092 A65092 # Pfam PF00419 Fimbrial # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGIL_ECOLI Uncharacterized fimbrial-like protein YgiL # RefSeq NP_417515 NC_000913.3 # RefSeq WP_001272145 NZ_LN832404.1 # SIMILARITY Belongs to the fimbrial protein family. {ECO 0000305}. # SUBCELLULAR LOCATION YGIL_ECOLI Fimbrium {ECO 0000305}. # SUPFAM SSF49401 SSF49401 # eggNOG ENOG4105H8W Bacteria # eggNOG ENOG4111SNU LUCA BLAST swissprot:YGIL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGIL_ECOLI BioCyc ECOL316407:JW3011-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3011-MONOMER BioCyc EcoCyc:EG12363-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12363-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M64472 http://www.ebi.ac.uk/ena/data/view/M64472 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2266 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2266 EcoGene EG12363 http://www.ecogene.org/geneInfo.php?eg_id=EG12363 EnsemblBacteria AAC76079 http://www.ensemblgenomes.org/id/AAC76079 EnsemblBacteria AAC76079 http://www.ensemblgenomes.org/id/AAC76079 EnsemblBacteria BAE77099 http://www.ensemblgenomes.org/id/BAE77099 EnsemblBacteria BAE77099 http://www.ensemblgenomes.org/id/BAE77099 EnsemblBacteria BAE77099 http://www.ensemblgenomes.org/id/BAE77099 EnsemblBacteria b3043 http://www.ensemblgenomes.org/id/b3043 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009289 GO_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 Gene3D 2.60.40.1090 http://www.cathdb.info/version/latest/superfamily/2.60.40.1090 GeneID 947522 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947522 HOGENOM HOG000260127 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260127&db=HOGENOM6 InParanoid P39834 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39834 IntAct P39834 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39834* InterPro IPR000259 http://www.ebi.ac.uk/interpro/entry/IPR000259 InterPro IPR008966 http://www.ebi.ac.uk/interpro/entry/IPR008966 KEGG_Gene ecj:JW3011 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3011 KEGG_Gene eco:b3043 http://www.genome.jp/dbget-bin/www_bget?eco:b3043 OMA EDINVNM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EDINVNM PSORT swissprot:YGIL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGIL_ECOLI PSORT-B swissprot:YGIL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGIL_ECOLI PSORT2 swissprot:YGIL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGIL_ECOLI Pfam PF00419 http://pfam.xfam.org/family/PF00419 Phobius swissprot:YGIL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGIL_ECOLI PhylomeDB P39834 http://phylomedb.org/?seqid=P39834 ProteinModelPortal P39834 http://www.proteinmodelportal.org/query/uniprot/P39834 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1917833 http://www.ncbi.nlm.nih.gov/pubmed/1917833 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417515 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417515 RefSeq WP_001272145 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001272145 STRING 511145.b3043 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3043&targetmode=cogs SUPFAM SSF49401 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49401 UniProtKB YGIL_ECOLI http://www.uniprot.org/uniprot/YGIL_ECOLI UniProtKB-AC P39834 http://www.uniprot.org/uniprot/P39834 charge swissprot:YGIL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGIL_ECOLI eggNOG ENOG4105H8W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105H8W eggNOG ENOG4111SNU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111SNU epestfind swissprot:YGIL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGIL_ECOLI garnier swissprot:YGIL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGIL_ECOLI helixturnhelix swissprot:YGIL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGIL_ECOLI hmoment swissprot:YGIL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGIL_ECOLI iep swissprot:YGIL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGIL_ECOLI inforesidue swissprot:YGIL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGIL_ECOLI octanol swissprot:YGIL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGIL_ECOLI pepcoil swissprot:YGIL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGIL_ECOLI pepdigest swissprot:YGIL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGIL_ECOLI pepinfo swissprot:YGIL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGIL_ECOLI pepnet swissprot:YGIL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGIL_ECOLI pepstats swissprot:YGIL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGIL_ECOLI pepwheel swissprot:YGIL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGIL_ECOLI pepwindow swissprot:YGIL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGIL_ECOLI sigcleave swissprot:YGIL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGIL_ECOLI ## Database ID URL or Descriptions # BioGrid 4261254 236 # EcoGene EG13566 wza # FUNCTION WZA_ECOLI Probably involved in the export of the extracellular polysaccharide colanic acid from the cell to medium. # GO_component GO:0009279 cell outer membrane; IEA:UniProtKB-SubCell. # GO_component GO:0046930 pore complex; IEA:UniProtKB-KW. # GO_function GO:0015159 polysaccharide transmembrane transporter activity; IEA:InterPro. # GO_function GO:0015288 porin activity; IEA:UniProtKB-KW. # GO_process GO:0000271 polysaccharide biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0006811 ion transport; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043234 protein complex # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006810 transport # GOslim_process GO:0009058 biosynthetic process # InterPro IPR003715 Poly_export # InterPro IPR019554 Soluble_ligand-bd # KEGG_Brite ko02000 Transporters # Organism WZA_ECOLI Escherichia coli (strain K12) # PATHWAY WZA_ECOLI Glycan metabolism; exopolysaccharide biosynthesis. # PATRIC 32119457 VBIEscCol129921_2139 # PIR E64972 E64972 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF02563 Poly_export # Pfam PF10531 SLBB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName WZA_ECOLI Putative polysaccharide export protein wza # RefSeq NP_416566 NC_000913.3 # RefSeq WP_000978094 NZ_LN832404.1 # SIMILARITY Belongs to the BexD/CtrA/VexA family. {ECO 0000305}. # SUBCELLULAR LOCATION WZA_ECOLI Cell outer membrane {ECO 0000250}; Multi- pass membrane protein {ECO 0000250}. # TCDB 1.B.18.3 the outer membrane auxiliary (oma) protein family # eggNOG COG1596 LUCA # eggNOG ENOG4105DAY Bacteria BLAST swissprot:WZA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:WZA_ECOLI BioCyc ECOL316407:JW2047-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2047-MONOMER BioCyc EcoCyc:G7107-MONOMER http://biocyc.org/getid?id=EcoCyc:G7107-MONOMER BioCyc MetaCyc:G7107-MONOMER http://biocyc.org/getid?id=MetaCyc:G7107-MONOMER COG COG1596 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1596 DIP DIP-11134N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11134N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U38473 http://www.ebi.ac.uk/ena/data/view/U38473 EMBL U52666 http://www.ebi.ac.uk/ena/data/view/U52666 EchoBASE EB3336 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3336 EcoGene EG13566 http://www.ecogene.org/geneInfo.php?eg_id=EG13566 EnsemblBacteria AAC75123 http://www.ensemblgenomes.org/id/AAC75123 EnsemblBacteria AAC75123 http://www.ensemblgenomes.org/id/AAC75123 EnsemblBacteria BAE76576 http://www.ensemblgenomes.org/id/BAE76576 EnsemblBacteria BAE76576 http://www.ensemblgenomes.org/id/BAE76576 EnsemblBacteria BAE76576 http://www.ensemblgenomes.org/id/BAE76576 EnsemblBacteria b2062 http://www.ensemblgenomes.org/id/b2062 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0046930 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046930 GO_function GO:0015159 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015159 GO_function GO:0015288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015288 GO_process GO:0000271 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000271 GO_process GO:0006811 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 946558 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946558 HOGENOM HOG000153886 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000153886&db=HOGENOM6 InParanoid P0A930 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A930 IntAct P0A930 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A930* InterPro IPR003715 http://www.ebi.ac.uk/interpro/entry/IPR003715 InterPro IPR019554 http://www.ebi.ac.uk/interpro/entry/IPR019554 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2047 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2047 KEGG_Gene eco:b2062 http://www.genome.jp/dbget-bin/www_bget?eco:b2062 KEGG_Orthology KO:K01991 http://www.genome.jp/dbget-bin/www_bget?KO:K01991 OMA PAGTYRT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PAGTYRT PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:WZA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:WZA_ECOLI PSORT-B swissprot:WZA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:WZA_ECOLI PSORT2 swissprot:WZA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:WZA_ECOLI Pfam PF02563 http://pfam.xfam.org/family/PF02563 Pfam PF10531 http://pfam.xfam.org/family/PF10531 Phobius swissprot:WZA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:WZA_ECOLI PhylomeDB P0A930 http://phylomedb.org/?seqid=P0A930 ProteinModelPortal P0A930 http://www.proteinmodelportal.org/query/uniprot/P0A930 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8759852 http://www.ncbi.nlm.nih.gov/pubmed/8759852 PubMed 8763957 http://www.ncbi.nlm.nih.gov/pubmed/8763957 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416566 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416566 RefSeq WP_000978094 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000978094 SMR P0A930 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A930 STRING 511145.b2062 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2062&targetmode=cogs STRING COG1596 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1596&targetmode=cogs TCDB 1.B.18.3 http://www.tcdb.org/search/result.php?tc=1.B.18.3 UniProtKB WZA_ECOLI http://www.uniprot.org/uniprot/WZA_ECOLI UniProtKB-AC P0A930 http://www.uniprot.org/uniprot/P0A930 charge swissprot:WZA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:WZA_ECOLI eggNOG COG1596 http://eggnogapi.embl.de/nog_data/html/tree/COG1596 eggNOG ENOG4105DAY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DAY epestfind swissprot:WZA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:WZA_ECOLI garnier swissprot:WZA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:WZA_ECOLI helixturnhelix swissprot:WZA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:WZA_ECOLI hmoment swissprot:WZA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:WZA_ECOLI iep swissprot:WZA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:WZA_ECOLI inforesidue swissprot:WZA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:WZA_ECOLI octanol swissprot:WZA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:WZA_ECOLI pepcoil swissprot:WZA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:WZA_ECOLI pepdigest swissprot:WZA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:WZA_ECOLI pepinfo swissprot:WZA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:WZA_ECOLI pepnet swissprot:WZA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:WZA_ECOLI pepstats swissprot:WZA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:WZA_ECOLI pepwheel swissprot:WZA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:WZA_ECOLI pepwindow swissprot:WZA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:WZA_ECOLI sigcleave swissprot:WZA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:WZA_ECOLI ## Database ID URL or Descriptions # AltName NAD-dependent glyceraldehyde-3-phosphate dehydrogenase {ECO:0000303|PubMed 2659073} # BIOPHYSICOCHEMICAL PROPERTIES G3P1_ECOLI Kinetic parameters KM=15 uM for BPG {ECO 0000269|PubMed 2659073}; KM=42 uM for NAD {ECO 0000269|PubMed 2659073}; KM=1500 uM for G3P {ECO 0000269|PubMed 2659073}; Note=Kcat is 1056 sec(-1) for dehydrogenase activity.; # BRENDA 1.2.1.12 2026 # BioGrid 4260308 24 # CATALYTIC ACTIVITY D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH. {ECO:0000269|PubMed 2659073}. # EcoGene EG10367 gapA # FUNCTION G3P1_ECOLI Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG. {ECO 0000269|PubMed 2659073}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity; IDA:UniProtKB. # GO_function GO:0050661 NADP binding; IEA:InterPro. # GO_function GO:0051287 NAD binding; IDA:UniProtKB. # GO_process GO:0006006 glucose metabolic process; IEA:InterPro. # GO_process GO:0006096 glycolytic process; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.720 -; 1. # IntAct P0A9B2 25 # InterPro IPR006424 Glyceraldehyde-3-P_DH_1 # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR020828 GlycerAld_3-P_DH_NAD(P)-bd # InterPro IPR020829 GlycerAld_3-P_DH_cat # InterPro IPR020830 GlycerAld_3-P_DH_AS # InterPro IPR020831 GlycerAld/Erythrose_P_DH # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00010 Glycolysis / Gluconeogenesis # KEGG_Pathway ko04066 HIF-1 signaling pathway # KEGG_Pathway ko05010 Alzheimer's disease # Organism G3P1_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10836 PTHR10836 # PATHWAY Carbohydrate degradation; glycolysis; pyruvate from D- glyceraldehyde 3-phosphate: step 1/5. {ECO 0000305}. # PATRIC 32118869 VBIEscCol129921_1852 # PDB 1DC3 X-ray; 2.50 A; A/B=2-331 # PDB 1DC4 X-ray; 2.50 A; A/B=2-331 # PDB 1DC5 X-ray; 2.00 A; A/B=2-331 # PDB 1DC6 X-ray; 2.00 A; A/B=2-331 # PDB 1GAD X-ray; 1.80 A; O/P=2-331 # PDB 1GAE X-ray; 2.17 A; O/P=2-331 # PDB 1S7C X-ray; 2.04 A; A=1-331 # PDB 2VYN X-ray; 2.20 A; A/B/C=1-331 # PDB 2VYV X-ray; 2.38 A; A/B/C=1-331 # PIR A25209 DEECG3 # PIRSF PIRSF000149 GAP_DH # PRINTS PR00078 G3PDHDRGNASE # PROSITE PS00071 GAPDH # Pfam PF00044 Gp_dh_N # Pfam PF02800 Gp_dh_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Glyceraldehyde-3-phosphate dehydrogenase A {ECO:0000303|PubMed 2659073} # RefSeq NP_416293 NC_000913.3 # RefSeq WP_000153502 NZ_LN832404.1 # SIMILARITY Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. {ECO 0000305}. # SMART SM00846 Gp_dh_N # SUBCELLULAR LOCATION G3P1_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT G3P1_ECOLI Homotetramer. {ECO 0000269|PubMed 10978154, ECO 0000269|PubMed 19542219, ECO 0000269|PubMed 8636984}. # SUPFAM SSF51735 SSF51735 # TIGRFAMs TIGR01534 GAPDH-I # UniPathway UPA00109 UER00184 # eggNOG COG0057 LUCA # eggNOG ENOG4105C17 Bacteria BLAST swissprot:G3P1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:G3P1_ECOLI BioCyc ECOL316407:JW1768-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1768-MONOMER BioCyc EcoCyc:GAPDH-A-MONOMER http://biocyc.org/getid?id=EcoCyc:GAPDH-A-MONOMER BioCyc MetaCyc:GAPDH-A-MONOMER http://biocyc.org/getid?id=MetaCyc:GAPDH-A-MONOMER COG COG0057 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0057 DIP DIP-31848N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31848N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1996.0204 http://dx.doi.org/10.1006/jmbi.1996.0204 DOI 10.1007/BF02106053 http://dx.doi.org/10.1007/BF02106053 DOI 10.1021/bi00432a036 http://dx.doi.org/10.1021/bi00432a036 DOI 10.1021/bi9927080 http://dx.doi.org/10.1021/bi9927080 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nchembio.495 http://dx.doi.org/10.1038/nchembio.495 DOI 10.1073/pnas.88.15.6667 http://dx.doi.org/10.1073/pnas.88.15.6667 DOI 10.1074/jbc.M109.004648 http://dx.doi.org/10.1074/jbc.M109.004648 DOI 10.1074/mcp.M111.012658 http://dx.doi.org/10.1074/mcp.M111.012658 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1111/j.1432-1033.1985.tb08988.x http://dx.doi.org/10.1111/j.1432-1033.1985.tb08988.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.2.1.12 {ECO:0000269|PubMed:2659073} http://www.genome.jp/dbget-bin/www_bget?EC:1.2.1.12 {ECO:0000269|PubMed:2659073} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M66870 http://www.ebi.ac.uk/ena/data/view/M66870 EMBL M66871 http://www.ebi.ac.uk/ena/data/view/M66871 EMBL M66872 http://www.ebi.ac.uk/ena/data/view/M66872 EMBL M66873 http://www.ebi.ac.uk/ena/data/view/M66873 EMBL M66874 http://www.ebi.ac.uk/ena/data/view/M66874 EMBL M66875 http://www.ebi.ac.uk/ena/data/view/M66875 EMBL M66876 http://www.ebi.ac.uk/ena/data/view/M66876 EMBL M66877 http://www.ebi.ac.uk/ena/data/view/M66877 EMBL M66878 http://www.ebi.ac.uk/ena/data/view/M66878 EMBL M66879 http://www.ebi.ac.uk/ena/data/view/M66879 EMBL M66880 http://www.ebi.ac.uk/ena/data/view/M66880 EMBL M66881 http://www.ebi.ac.uk/ena/data/view/M66881 EMBL M66882 http://www.ebi.ac.uk/ena/data/view/M66882 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U07750 http://www.ebi.ac.uk/ena/data/view/U07750 EMBL U07751 http://www.ebi.ac.uk/ena/data/view/U07751 EMBL U07752 http://www.ebi.ac.uk/ena/data/view/U07752 EMBL U07754 http://www.ebi.ac.uk/ena/data/view/U07754 EMBL U07765 http://www.ebi.ac.uk/ena/data/view/U07765 EMBL U07768 http://www.ebi.ac.uk/ena/data/view/U07768 EMBL U07769 http://www.ebi.ac.uk/ena/data/view/U07769 EMBL U07770 http://www.ebi.ac.uk/ena/data/view/U07770 EMBL U07771 http://www.ebi.ac.uk/ena/data/view/U07771 EMBL U07772 http://www.ebi.ac.uk/ena/data/view/U07772 EMBL U07773 http://www.ebi.ac.uk/ena/data/view/U07773 EMBL X02662 http://www.ebi.ac.uk/ena/data/view/X02662 ENZYME 1.2.1.12 {ECO:0000269|PubMed:2659073} http://enzyme.expasy.org/EC/1.2.1.12 {ECO:0000269|PubMed:2659073} EchoBASE EB0362 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0362 EcoGene EG10367 http://www.ecogene.org/geneInfo.php?eg_id=EG10367 EnsemblBacteria AAC74849 http://www.ensemblgenomes.org/id/AAC74849 EnsemblBacteria AAC74849 http://www.ensemblgenomes.org/id/AAC74849 EnsemblBacteria BAA15576 http://www.ensemblgenomes.org/id/BAA15576 EnsemblBacteria BAA15576 http://www.ensemblgenomes.org/id/BAA15576 EnsemblBacteria BAA15576 http://www.ensemblgenomes.org/id/BAA15576 EnsemblBacteria b1779 http://www.ensemblgenomes.org/id/b1779 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0004365 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004365 GO_function GO:0050661 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050661 GO_function GO:0051287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051287 GO_process GO:0006006 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006006 GO_process GO:0006096 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006096 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 947679 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947679 HOGENOM HOG000071678 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000071678&db=HOGENOM6 InParanoid P0A9B2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9B2 IntAct P0A9B2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9B2* IntEnz 1.2.1.12 {ECO:0000269|PubMed:2659073} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.2.1.12 {ECO:0000269|PubMed:2659073} InterPro IPR006424 http://www.ebi.ac.uk/interpro/entry/IPR006424 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR020828 http://www.ebi.ac.uk/interpro/entry/IPR020828 InterPro IPR020829 http://www.ebi.ac.uk/interpro/entry/IPR020829 InterPro IPR020830 http://www.ebi.ac.uk/interpro/entry/IPR020830 InterPro IPR020831 http://www.ebi.ac.uk/interpro/entry/IPR020831 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1768 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1768 KEGG_Gene eco:b1779 http://www.genome.jp/dbget-bin/www_bget?eco:b1779 KEGG_Orthology KO:K00134 http://www.genome.jp/dbget-bin/www_bget?KO:K00134 KEGG_Pathway ko00010 http://www.genome.jp/kegg-bin/show_pathway?ko00010 KEGG_Pathway ko04066 http://www.genome.jp/kegg-bin/show_pathway?ko04066 KEGG_Pathway ko05010 http://www.genome.jp/kegg-bin/show_pathway?ko05010 KEGG_Reaction rn:R01061 http://www.genome.jp/dbget-bin/www_bget?rn:R01061 MINT MINT-1255410 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1255410 OMA KWGEVGA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KWGEVGA PANTHER PTHR10836 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10836 PDB 1DC3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1DC3 PDB 1DC4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1DC4 PDB 1DC5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1DC5 PDB 1DC6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1DC6 PDB 1GAD http://www.ebi.ac.uk/pdbe-srv/view/entry/1GAD PDB 1GAE http://www.ebi.ac.uk/pdbe-srv/view/entry/1GAE PDB 1S7C http://www.ebi.ac.uk/pdbe-srv/view/entry/1S7C PDB 2VYN http://www.ebi.ac.uk/pdbe-srv/view/entry/2VYN PDB 2VYV http://www.ebi.ac.uk/pdbe-srv/view/entry/2VYV PDBsum 1DC3 http://www.ebi.ac.uk/pdbsum/1DC3 PDBsum 1DC4 http://www.ebi.ac.uk/pdbsum/1DC4 PDBsum 1DC5 http://www.ebi.ac.uk/pdbsum/1DC5 PDBsum 1DC6 http://www.ebi.ac.uk/pdbsum/1DC6 PDBsum 1GAD http://www.ebi.ac.uk/pdbsum/1GAD PDBsum 1GAE http://www.ebi.ac.uk/pdbsum/1GAE PDBsum 1S7C http://www.ebi.ac.uk/pdbsum/1S7C PDBsum 2VYN http://www.ebi.ac.uk/pdbsum/2VYN PDBsum 2VYV http://www.ebi.ac.uk/pdbsum/2VYV PRINTS PR00078 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00078 PROSITE PS00071 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00071 PSORT swissprot:G3P1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:G3P1_ECOLI PSORT-B swissprot:G3P1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:G3P1_ECOLI PSORT2 swissprot:G3P1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:G3P1_ECOLI Pfam PF00044 http://pfam.xfam.org/family/PF00044 Pfam PF02800 http://pfam.xfam.org/family/PF02800 Phobius swissprot:G3P1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:G3P1_ECOLI PhylomeDB P0A9B2 http://phylomedb.org/?seqid=P0A9B2 ProteinModelPortal P0A9B2 http://www.proteinmodelportal.org/query/uniprot/P0A9B2 PubMed 10978154 http://www.ncbi.nlm.nih.gov/pubmed/10978154 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1862091 http://www.ncbi.nlm.nih.gov/pubmed/1862091 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 19542219 http://www.ncbi.nlm.nih.gov/pubmed/19542219 PubMed 21151122 http://www.ncbi.nlm.nih.gov/pubmed/21151122 PubMed 2124629 http://www.ncbi.nlm.nih.gov/pubmed/2124629 PubMed 21908771 http://www.ncbi.nlm.nih.gov/pubmed/21908771 PubMed 2659073 http://www.ncbi.nlm.nih.gov/pubmed/2659073 PubMed 2990926 http://www.ncbi.nlm.nih.gov/pubmed/2990926 PubMed 7896119 http://www.ncbi.nlm.nih.gov/pubmed/7896119 PubMed 8636984 http://www.ncbi.nlm.nih.gov/pubmed/8636984 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_416293 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416293 RefSeq WP_000153502 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000153502 SMART SM00846 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00846 SMR P0A9B2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9B2 STRING 511145.b1779 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1779&targetmode=cogs STRING COG0057 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0057&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 SWISS-2DPAGE P0A9B2 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A9B2 TIGRFAMs TIGR01534 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01534 UniProtKB G3P1_ECOLI http://www.uniprot.org/uniprot/G3P1_ECOLI UniProtKB-AC P0A9B2 http://www.uniprot.org/uniprot/P0A9B2 charge swissprot:G3P1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:G3P1_ECOLI eggNOG COG0057 http://eggnogapi.embl.de/nog_data/html/tree/COG0057 eggNOG ENOG4105C17 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C17 epestfind swissprot:G3P1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:G3P1_ECOLI garnier swissprot:G3P1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:G3P1_ECOLI helixturnhelix swissprot:G3P1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:G3P1_ECOLI hmoment swissprot:G3P1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:G3P1_ECOLI iep swissprot:G3P1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:G3P1_ECOLI inforesidue swissprot:G3P1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:G3P1_ECOLI octanol swissprot:G3P1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:G3P1_ECOLI pepcoil swissprot:G3P1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:G3P1_ECOLI pepdigest swissprot:G3P1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:G3P1_ECOLI pepinfo swissprot:G3P1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:G3P1_ECOLI pepnet swissprot:G3P1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:G3P1_ECOLI pepstats swissprot:G3P1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:G3P1_ECOLI pepwheel swissprot:G3P1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:G3P1_ECOLI pepwindow swissprot:G3P1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:G3P1_ECOLI sigcleave swissprot:G3P1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:G3P1_ECOLI ## Database ID URL or Descriptions # AltName GSPM_ECOLI Putative general secretion pathway protein M # AltName GSPM_ECOLI Transport protein PshM # BioGrid 4262464 145 # EcoGene EG12173 gspM # FUNCTION GSPM_ECOLI Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. {ECO 0000305}. # GO_component GO:0005576 extracellular region; IEA:GOC. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006858 extracellular transport; IEA:InterPro. # GO_process GO:0015031 protein transport; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005576 extracellular region # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006810 transport # INDUCTION Silenced by the DNA-binding protein H-NS under standard growth conditions. {ECO:0000269|PubMed 11118204}. # InterPro IPR007690 T2SS_M # InterPro IPR023229 T2SS_M_periplasmic # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02044 M00331 Type II general secretion system # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko03070 Bacterial secretion system # MISCELLANEOUS GSPM_ECOLI Part of a cryptic operon that encodes proteins involved in type II secretion machinery in other organisms, but is not expressed in strain K12. # Organism GSPM_ECOLI Escherichia coli (strain K12) # PATRIC 32122100 VBIEscCol129921_3427 # PIR A65127 A65127 # Pfam PF04612 T2SSM # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GSPM_ECOLI Putative type II secretion system protein M # RefSeq NP_417793 NC_000913.3 # RefSeq WP_001295161 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA58131.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAC36927.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the GSP M family. {ECO 0000305}. # SUBCELLULAR LOCATION GSPM_ECOLI Cell inner membrane {ECO 0000305}; Single- pass membrane protein {ECO 0000305}. # SUPFAM SSF103054 SSF103054 # eggNOG ENOG410ZA7S LUCA BLAST swissprot:GSPM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GSPM_ECOLI BioCyc ECOL316407:JW5704-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5704-MONOMER BioCyc EcoCyc:EG12173-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12173-MONOMER BioCyc MetaCyc:EG12173-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12173-MONOMER COG COG3149 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3149 DOI 10.1016/0378-1119(94)90851-6 http://dx.doi.org/10.1016/0378-1119(94)90851-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/emboj/19.24.6697 http://dx.doi.org/10.1093/emboj/19.24.6697 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L28106 http://www.ebi.ac.uk/ena/data/view/L28106 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2091 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2091 EcoGene EG12173 http://www.ecogene.org/geneInfo.php?eg_id=EG12173 EnsemblBacteria AAC76359 http://www.ensemblgenomes.org/id/AAC76359 EnsemblBacteria AAC76359 http://www.ensemblgenomes.org/id/AAC76359 EnsemblBacteria BAE77957 http://www.ensemblgenomes.org/id/BAE77957 EnsemblBacteria BAE77957 http://www.ensemblgenomes.org/id/BAE77957 EnsemblBacteria BAE77957 http://www.ensemblgenomes.org/id/BAE77957 EnsemblBacteria b3334 http://www.ensemblgenomes.org/id/b3334 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005576 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006858 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006858 GO_process GO:0015031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005576 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 947841 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947841 HOGENOM HOG000125397 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125397&db=HOGENOM6 InterPro IPR007690 http://www.ebi.ac.uk/interpro/entry/IPR007690 InterPro IPR023229 http://www.ebi.ac.uk/interpro/entry/IPR023229 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW5704 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5704 KEGG_Gene eco:b3334 http://www.genome.jp/dbget-bin/www_bget?eco:b3334 KEGG_Orthology KO:K02462 http://www.genome.jp/dbget-bin/www_bget?KO:K02462 KEGG_Pathway ko03070 http://www.genome.jp/kegg-bin/show_pathway?ko03070 OMA KCHERCN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KCHERCN PSORT swissprot:GSPM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GSPM_ECOLI PSORT-B swissprot:GSPM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GSPM_ECOLI PSORT2 swissprot:GSPM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GSPM_ECOLI Pfam PF04612 http://pfam.xfam.org/family/PF04612 Phobius swissprot:GSPM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GSPM_ECOLI ProteinModelPortal P36678 http://www.proteinmodelportal.org/query/uniprot/P36678 PubMed 11118204 http://www.ncbi.nlm.nih.gov/pubmed/11118204 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7959070 http://www.ncbi.nlm.nih.gov/pubmed/7959070 PubMed 8655552 http://www.ncbi.nlm.nih.gov/pubmed/8655552 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417793 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417793 RefSeq WP_001295161 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295161 STRING 511145.b3334 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3334&targetmode=cogs STRING COG3149 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3149&targetmode=cogs SUPFAM SSF103054 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103054 UniProtKB GSPM_ECOLI http://www.uniprot.org/uniprot/GSPM_ECOLI UniProtKB-AC P36678 http://www.uniprot.org/uniprot/P36678 charge swissprot:GSPM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GSPM_ECOLI eggNOG ENOG410ZA7S http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZA7S epestfind swissprot:GSPM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GSPM_ECOLI garnier swissprot:GSPM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GSPM_ECOLI helixturnhelix swissprot:GSPM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GSPM_ECOLI hmoment swissprot:GSPM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GSPM_ECOLI iep swissprot:GSPM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GSPM_ECOLI inforesidue swissprot:GSPM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GSPM_ECOLI octanol swissprot:GSPM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GSPM_ECOLI pepcoil swissprot:GSPM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GSPM_ECOLI pepdigest swissprot:GSPM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GSPM_ECOLI pepinfo swissprot:GSPM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GSPM_ECOLI pepnet swissprot:GSPM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GSPM_ECOLI pepstats swissprot:GSPM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GSPM_ECOLI pepwheel swissprot:GSPM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GSPM_ECOLI pepwindow swissprot:GSPM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GSPM_ECOLI sigcleave swissprot:GSPM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GSPM_ECOLI ## Database ID URL or Descriptions # BioGrid 4261723 7 # CDD cd07153 Fur_like # EcoGene EG11929 zur # FUNCTION ZUR_ECOLI Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes (znuACB). # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IDA:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # InterPro IPR002481 FUR # InterPro IPR011991 WHTH_DNA-bd_dom # KEGG_Brite ko03000 Transcription factors # Organism ZUR_ECOLI Escherichia coli (strain K12) # PATRIC 32123629 VBIEscCol129921_4163 # PDB 4MTD X-ray; 2.50 A; A/B/C/D=1-171 # PDB 4MTE X-ray; 2.50 A; A/B/C/D=1-171 # PIR E65212 E65212 # Pfam PF01475 FUR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ZUR_ECOLI Zinc uptake regulation protein # RefSeq NP_418470 NC_000913.3 # RefSeq WP_001295691 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAC43140.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the Fur family. {ECO 0000305}. # SUPFAM SSF46785 SSF46785 # eggNOG COG0735 LUCA # eggNOG ENOG4105MYN Bacteria BLAST swissprot:ZUR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ZUR_ECOLI BioCyc ECOL316407:JW5714-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5714-MONOMER BioCyc EcoCyc:EG11929-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11929-MONOMER COG COG0735 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0735 DIP DIP-12953N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12953N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1998.00883.x http://dx.doi.org/10.1046/j.1365-2958.1998.00883.x DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1873 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1873 EcoGene EG11929 http://www.ecogene.org/geneInfo.php?eg_id=EG11929 EnsemblBacteria AAC77016 http://www.ensemblgenomes.org/id/AAC77016 EnsemblBacteria AAC77016 http://www.ensemblgenomes.org/id/AAC77016 EnsemblBacteria BAE78048 http://www.ensemblgenomes.org/id/BAE78048 EnsemblBacteria BAE78048 http://www.ensemblgenomes.org/id/BAE78048 EnsemblBacteria BAE78048 http://www.ensemblgenomes.org/id/BAE78048 EnsemblBacteria b4046 http://www.ensemblgenomes.org/id/b4046 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 948552 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948552 HOGENOM HOG000014146 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000014146&db=HOGENOM6 InParanoid P0AC51 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AC51 InterPro IPR002481 http://www.ebi.ac.uk/interpro/entry/IPR002481 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW5714 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5714 KEGG_Gene eco:b4046 http://www.genome.jp/dbget-bin/www_bget?eco:b4046 KEGG_Orthology KO:K09823 http://www.genome.jp/dbget-bin/www_bget?KO:K09823 OMA DHSHCVH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DHSHCVH PDB 4MTD http://www.ebi.ac.uk/pdbe-srv/view/entry/4MTD PDB 4MTE http://www.ebi.ac.uk/pdbe-srv/view/entry/4MTE PDBsum 4MTD http://www.ebi.ac.uk/pdbsum/4MTD PDBsum 4MTE http://www.ebi.ac.uk/pdbsum/4MTE PSORT swissprot:ZUR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ZUR_ECOLI PSORT-B swissprot:ZUR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ZUR_ECOLI PSORT2 swissprot:ZUR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ZUR_ECOLI Pfam PF01475 http://pfam.xfam.org/family/PF01475 Phobius swissprot:ZUR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ZUR_ECOLI PhylomeDB P0AC51 http://phylomedb.org/?seqid=P0AC51 ProteinModelPortal P0AC51 http://www.proteinmodelportal.org/query/uniprot/P0AC51 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9680209 http://www.ncbi.nlm.nih.gov/pubmed/9680209 RefSeq NP_418470 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418470 RefSeq WP_001295691 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295691 SMR P0AC51 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AC51 STRING 511145.b4046 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4046&targetmode=cogs STRING COG0735 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0735&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB ZUR_ECOLI http://www.uniprot.org/uniprot/ZUR_ECOLI UniProtKB-AC P0AC51 http://www.uniprot.org/uniprot/P0AC51 charge swissprot:ZUR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ZUR_ECOLI eggNOG COG0735 http://eggnogapi.embl.de/nog_data/html/tree/COG0735 eggNOG ENOG4105MYN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105MYN epestfind swissprot:ZUR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ZUR_ECOLI garnier swissprot:ZUR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ZUR_ECOLI helixturnhelix swissprot:ZUR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ZUR_ECOLI hmoment swissprot:ZUR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ZUR_ECOLI iep swissprot:ZUR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ZUR_ECOLI inforesidue swissprot:ZUR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ZUR_ECOLI octanol swissprot:ZUR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ZUR_ECOLI pepcoil swissprot:ZUR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ZUR_ECOLI pepdigest swissprot:ZUR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ZUR_ECOLI pepinfo swissprot:ZUR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ZUR_ECOLI pepnet swissprot:ZUR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ZUR_ECOLI pepstats swissprot:ZUR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ZUR_ECOLI pepwheel swissprot:ZUR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ZUR_ECOLI pepwindow swissprot:ZUR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ZUR_ECOLI sigcleave swissprot:ZUR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ZUR_ECOLI ## Database ID URL or Descriptions # BioGrid 4260361 41 # CATALYTIC ACTIVITY HOLE_ECOLI Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). # EcoGene EG11505 holE # FUNCTION HOLE_ECOLI DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. # FUNCTION HOLE_ECOLI The exact function of the theta subunit is unknown. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0044776 DNA polymerase III, core complex; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_function GO:0003887 DNA-directed DNA polymerase activity; IEA:UniProtKB-KW. # GO_process GO:0006260 DNA replication; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 1.10.1110.10 -; 1. # INTERACTION HOLE_ECOLI P03007 dnaQ; NbExp=11; IntAct=EBI-549182, EBI-549131; # IntAct P0ABS8 28 # InterPro IPR009052 DNA_pol_III_theta_bac # InterPro IPR011325 DNA_pol_III_theta_core_bac # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03032 DNA replication proteins # KEGG_Brite ko03032 M00260 DNA polymerase III complex, bacteria # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Brite ko03400 M00260 DNA polymerase III complex, bacteria # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00240 Pyrimidine metabolism # KEGG_Pathway ko03030 DNA replication # KEGG_Pathway ko03430 Mismatch repair # KEGG_Pathway ko03440 Homologous recombination # Organism HOLE_ECOLI Escherichia coli (strain K12) # PATRIC 32119005 VBIEscCol129921_1920 # PDB 1DU2 NMR; -; A=1-76 # PDB 2AE9 NMR; -; A=1-76 # PDB 2AXD NMR; -; S=1-76 # PDB 2XY8 NMR; -; B=1-76 # PIR S34951 S34951 # Pfam PF06440 DNA_pol3_theta # ProDom PD057609 DNA_pol_III_theta_bac # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HOLE_ECOLI DNA polymerase III subunit theta # RefSeq NP_416356 NC_000913.3 # RefSeq WP_000916763 NZ_LN832404.1 # SUBUNIT The DNA polymerase holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential subassemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core (subunits alpha,epsilon and theta) contains the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork. This complex contains delta, delta', psi and chi, and copies of either or both of two different DnaX proteins, gamma and tau. The composition of the holoenzyme is, therefore (alpha,epsilon,theta)[2]-(gamma/tau)[3]-delta,delta', psi,chi- beta[4]. # SUPFAM SSF46575 SSF46575 # eggNOG ENOG4105MPK Bacteria # eggNOG ENOG4111UZC LUCA BLAST swissprot:HOLE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HOLE_ECOLI BioCyc ECOL316407:JW1831-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1831-MONOMER BioCyc EcoCyc:EG11505-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11505-MONOMER BioCyc MetaCyc:EG11505-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11505-MONOMER DIP DIP-39982N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-39982N DOI 10.1002/bies.950140206 http://dx.doi.org/10.1002/bies.950140206 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/nar/21.14.3281 http://dx.doi.org/10.1093/nar/21.14.3281 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.7.7 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.7 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L04572 http://www.ebi.ac.uk/ena/data/view/L04572 EMBL L05381 http://www.ebi.ac.uk/ena/data/view/L05381 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.7.7 http://enzyme.expasy.org/EC/2.7.7.7 EchoBASE EB1468 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1468 EcoGene EG11505 http://www.ecogene.org/geneInfo.php?eg_id=EG11505 EnsemblBacteria AAC74912 http://www.ensemblgenomes.org/id/AAC74912 EnsemblBacteria AAC74912 http://www.ensemblgenomes.org/id/AAC74912 EnsemblBacteria BAA15650 http://www.ensemblgenomes.org/id/BAA15650 EnsemblBacteria BAA15650 http://www.ensemblgenomes.org/id/BAA15650 EnsemblBacteria BAA15650 http://www.ensemblgenomes.org/id/BAA15650 EnsemblBacteria b1842 http://www.ensemblgenomes.org/id/b1842 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0044776 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044776 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003887 GO_process GO:0006260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 1.10.1110.10 http://www.cathdb.info/version/latest/superfamily/1.10.1110.10 GeneID 947471 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947471 HOGENOM HOG000219272 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219272&db=HOGENOM6 IntAct P0ABS8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABS8* IntEnz 2.7.7.7 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.7 InterPro IPR009052 http://www.ebi.ac.uk/interpro/entry/IPR009052 InterPro IPR011325 http://www.ebi.ac.uk/interpro/entry/IPR011325 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03032 http://www.genome.jp/dbget-bin/www_bget?ko03032 KEGG_Brite ko03032 http://www.genome.jp/dbget-bin/www_bget?ko03032 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW1831 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1831 KEGG_Gene eco:b1842 http://www.genome.jp/dbget-bin/www_bget?eco:b1842 KEGG_Orthology KO:K02345 http://www.genome.jp/dbget-bin/www_bget?KO:K02345 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Pathway ko03030 http://www.genome.jp/kegg-bin/show_pathway?ko03030 KEGG_Pathway ko03430 http://www.genome.jp/kegg-bin/show_pathway?ko03430 KEGG_Pathway ko03440 http://www.genome.jp/kegg-bin/show_pathway?ko03440 KEGG_Reaction rn:R00375 http://www.genome.jp/dbget-bin/www_bget?rn:R00375 KEGG_Reaction rn:R00376 http://www.genome.jp/dbget-bin/www_bget?rn:R00376 KEGG_Reaction rn:R00377 http://www.genome.jp/dbget-bin/www_bget?rn:R00377 KEGG_Reaction rn:R00378 http://www.genome.jp/dbget-bin/www_bget?rn:R00378 MINT MINT-1223798 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1223798 OMA FRERYNM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FRERYNM PDB 1DU2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1DU2 PDB 2AE9 http://www.ebi.ac.uk/pdbe-srv/view/entry/2AE9 PDB 2AXD http://www.ebi.ac.uk/pdbe-srv/view/entry/2AXD PDB 2XY8 http://www.ebi.ac.uk/pdbe-srv/view/entry/2XY8 PDBsum 1DU2 http://www.ebi.ac.uk/pdbsum/1DU2 PDBsum 2AE9 http://www.ebi.ac.uk/pdbsum/2AE9 PDBsum 2AXD http://www.ebi.ac.uk/pdbsum/2AXD PDBsum 2XY8 http://www.ebi.ac.uk/pdbsum/2XY8 PSORT swissprot:HOLE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HOLE_ECOLI PSORT-B swissprot:HOLE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HOLE_ECOLI PSORT2 swissprot:HOLE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HOLE_ECOLI Pfam PF06440 http://pfam.xfam.org/family/PF06440 Phobius swissprot:HOLE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HOLE_ECOLI ProteinModelPortal P0ABS8 http://www.proteinmodelportal.org/query/uniprot/P0ABS8 PubMed 1575709 http://www.ncbi.nlm.nih.gov/pubmed/1575709 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8341603 http://www.ncbi.nlm.nih.gov/pubmed/8341603 PubMed 8505306 http://www.ncbi.nlm.nih.gov/pubmed/8505306 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416356 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416356 RefSeq WP_000916763 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000916763 SMR P0ABS8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABS8 STRING 511145.b1842 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1842&targetmode=cogs SUPFAM SSF46575 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46575 UniProtKB HOLE_ECOLI http://www.uniprot.org/uniprot/HOLE_ECOLI UniProtKB-AC P0ABS8 http://www.uniprot.org/uniprot/P0ABS8 charge swissprot:HOLE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HOLE_ECOLI eggNOG ENOG4105MPK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105MPK eggNOG ENOG4111UZC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111UZC epestfind swissprot:HOLE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HOLE_ECOLI garnier swissprot:HOLE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HOLE_ECOLI helixturnhelix swissprot:HOLE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HOLE_ECOLI hmoment swissprot:HOLE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HOLE_ECOLI iep swissprot:HOLE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HOLE_ECOLI inforesidue swissprot:HOLE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HOLE_ECOLI octanol swissprot:HOLE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HOLE_ECOLI pepcoil swissprot:HOLE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HOLE_ECOLI pepdigest swissprot:HOLE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HOLE_ECOLI pepinfo swissprot:HOLE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HOLE_ECOLI pepnet swissprot:HOLE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HOLE_ECOLI pepstats swissprot:HOLE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HOLE_ECOLI pepwheel swissprot:HOLE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HOLE_ECOLI pepwindow swissprot:HOLE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HOLE_ECOLI sigcleave swissprot:HOLE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HOLE_ECOLI ## Database ID URL or Descriptions # BioGrid 4259891 18 # CDD cd00383 trans_reg_C # EcoGene EG13851 cusR # FUNCTION CUSR_ECOLI Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA and plasmid pRJ1004 gene pcoE in response to increasing levels of copper ions, and probably silver ions. Can also increase the basal-level expression of copper resistance gene operon pcoABCD. {ECO 0000269|PubMed 11004187, ECO 0000269|PubMed 11399769}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_process GO:0000160 phosphorelay signal transduction system; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IMP:EcoCyc. # GO_process GO:0010628 positive regulation of gene expression; IMP:EcoCyc. # GO_process GO:0046688 response to copper ion; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # INTERACTION CUSR_ECOLI Self; NbExp=2; IntAct=EBI-1118807, EBI-1118807; # IntAct P0ACZ8 9 # InterPro IPR001789 Sig_transdc_resp-reg_receiver # InterPro IPR001867 OmpR/PhoB-type_DNA-bd # InterPro IPR006291 PcoR # InterPro IPR011006 CheY-like_superfamily # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR016032 Sig_transdc_resp-reg_C-effctor # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02022 M00452 CusS-CusR (copper tolerance) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # MISCELLANEOUS CUSR_ECOLI The cus system plays an important role in copper tolerance under anaerobic growth and, under extreme copper stress, in aerobic growth. # Organism CUSR_ECOLI Escherichia coli (strain K12) # PATRIC 32116310 VBIEscCol129921_0595 # PIR A64790 A64790 # PROSITE PS50110 RESPONSE_REGULATORY # PROSITE PS51755 OMPR_PHOB # PTM CUSR_ECOLI Phosphorylated by CusS. {ECO 0000269|PubMed 15522865}. # Pfam PF00072 Response_reg # Pfam PF00486 Trans_reg_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CUSR_ECOLI Transcriptional regulatory protein CusR # RefSeq NP_415103 NC_000913.3 # RefSeq WP_000770953 NZ_LN832404.1 # SIMILARITY Contains 1 OmpR/PhoB-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU01091}. # SIMILARITY Contains 1 response regulatory domain. {ECO:0000255|PROSITE-ProRule PRU00169}. # SMART SM00448 REC # SMART SM00862 Trans_reg_C # SUBCELLULAR LOCATION CUSR_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF46894 SSF46894 # SUPFAM SSF52172 SSF52172 # TIGRFAMs TIGR01387 cztR_silR_copR # eggNOG COG0745 LUCA # eggNOG ENOG4105CK6 Bacteria BLAST swissprot:CUSR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CUSR_ECOLI BioCyc ECOL316407:JW0560-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0560-MONOMER BioCyc EcoCyc:G6319-MONOMER http://biocyc.org/getid?id=EcoCyc:G6319-MONOMER COG COG0745 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0745 DIP DIP-9348N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9348N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M104122200 http://dx.doi.org/10.1074/jbc.M104122200 DOI 10.1074/jbc.M410104200 http://dx.doi.org/10.1074/jbc.M410104200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.20.5864-5871.2000 http://dx.doi.org/10.1128/JB.182.20.5864-5871.2000 EMBL AF245661 http://www.ebi.ac.uk/ena/data/view/AF245661 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82579 http://www.ebi.ac.uk/ena/data/view/U82579 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB3612 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3612 EcoGene EG13851 http://www.ecogene.org/geneInfo.php?eg_id=EG13851 EnsemblBacteria AAC73672 http://www.ensemblgenomes.org/id/AAC73672 EnsemblBacteria AAC73672 http://www.ensemblgenomes.org/id/AAC73672 EnsemblBacteria BAA35205 http://www.ensemblgenomes.org/id/BAA35205 EnsemblBacteria BAA35205 http://www.ensemblgenomes.org/id/BAA35205 EnsemblBacteria BAA35205 http://www.ensemblgenomes.org/id/BAA35205 EnsemblBacteria b0571 http://www.ensemblgenomes.org/id/b0571 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0010628 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010628 GO_process GO:0046688 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046688 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 945003 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945003 HOGENOM HOG000034815 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000034815&db=HOGENOM6 InParanoid P0ACZ8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACZ8 IntAct P0ACZ8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACZ8* InterPro IPR001789 http://www.ebi.ac.uk/interpro/entry/IPR001789 InterPro IPR001867 http://www.ebi.ac.uk/interpro/entry/IPR001867 InterPro IPR006291 http://www.ebi.ac.uk/interpro/entry/IPR006291 InterPro IPR011006 http://www.ebi.ac.uk/interpro/entry/IPR011006 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR016032 http://www.ebi.ac.uk/interpro/entry/IPR016032 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW0560 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0560 KEGG_Gene eco:b0571 http://www.genome.jp/dbget-bin/www_bget?eco:b0571 KEGG_Orthology KO:K07665 http://www.genome.jp/dbget-bin/www_bget?KO:K07665 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA DKVTGFN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DKVTGFN PROSITE PS50110 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50110 PROSITE PS51755 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51755 PSORT swissprot:CUSR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CUSR_ECOLI PSORT-B swissprot:CUSR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CUSR_ECOLI PSORT2 swissprot:CUSR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CUSR_ECOLI Pfam PF00072 http://pfam.xfam.org/family/PF00072 Pfam PF00486 http://pfam.xfam.org/family/PF00486 Phobius swissprot:CUSR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CUSR_ECOLI PhylomeDB P0ACZ8 http://phylomedb.org/?seqid=P0ACZ8 ProteinModelPortal P0ACZ8 http://www.proteinmodelportal.org/query/uniprot/P0ACZ8 PubMed 11004187 http://www.ncbi.nlm.nih.gov/pubmed/11004187 PubMed 11283292 http://www.ncbi.nlm.nih.gov/pubmed/11283292 PubMed 11399769 http://www.ncbi.nlm.nih.gov/pubmed/11399769 PubMed 15522865 http://www.ncbi.nlm.nih.gov/pubmed/15522865 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415103 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415103 RefSeq WP_000770953 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000770953 SMART SM00448 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00448 SMART SM00862 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00862 SMR P0ACZ8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACZ8 STRING 511145.b0571 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0571&targetmode=cogs STRING COG0745 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0745&targetmode=cogs SUPFAM SSF46894 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46894 SUPFAM SSF52172 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52172 TIGRFAMs TIGR01387 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01387 UniProtKB CUSR_ECOLI http://www.uniprot.org/uniprot/CUSR_ECOLI UniProtKB-AC P0ACZ8 http://www.uniprot.org/uniprot/P0ACZ8 charge swissprot:CUSR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CUSR_ECOLI eggNOG COG0745 http://eggnogapi.embl.de/nog_data/html/tree/COG0745 eggNOG ENOG4105CK6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CK6 epestfind swissprot:CUSR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CUSR_ECOLI garnier swissprot:CUSR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CUSR_ECOLI helixturnhelix swissprot:CUSR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CUSR_ECOLI hmoment swissprot:CUSR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CUSR_ECOLI iep swissprot:CUSR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CUSR_ECOLI inforesidue swissprot:CUSR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CUSR_ECOLI octanol swissprot:CUSR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CUSR_ECOLI pepcoil swissprot:CUSR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CUSR_ECOLI pepdigest swissprot:CUSR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CUSR_ECOLI pepinfo swissprot:CUSR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CUSR_ECOLI pepnet swissprot:CUSR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CUSR_ECOLI pepstats swissprot:CUSR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CUSR_ECOLI pepwheel swissprot:CUSR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CUSR_ECOLI pepwindow swissprot:CUSR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CUSR_ECOLI sigcleave swissprot:CUSR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CUSR_ECOLI ## Database ID URL or Descriptions # AltName BISC_ECOLI L-methionine-(S)-sulfoxide reductase # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=17 uM for L-methionine (S)-S-oxide {ECO 0000269|PubMed:15601707}; Note=kcat is 3.2 min(-1) for the reduction of Met-S-SO using benzyl viologen as an artificial electron donor.; # BioGrid 4261247 8 # CATALYTIC ACTIVITY L-methionine + thioredoxin disulfide + H(2)O = L-methionine (S)-S-oxide + thioredoxin. {ECO:0000269|PubMed 15601707}. # COFACTOR BISC_ECOLI Name=Mo-bis(molybdopterin guanine dinucleotide); Xref=ChEBI CHEBI 60539; Evidence={ECO 0000305|PubMed 15601707, ECO 0000305|PubMed 6460021}; Note=Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit. {ECO 0000305|PubMed 15601707, ECO 0000305|PubMed 6460021}; # DISRUPTION PHENOTYPE Cells lacking this gene together with metB1, msrA and msrB are unable to use Met-S-SO for growth but retain the ability to use the enantiomer Met-R-SO, while a metB1/msrA/msrB deletion mutant is able to use both compounds. {ECO:0000269|PubMed 15601707}. # DOMAIN BISC_ECOLI The N-terminal 39 residues are essential for activity. {ECO 0000269|PubMed 15601707}. # EcoGene EG10124 bisC # FUNCTION BISC_ECOLI This enzyme may serve as a scavenger, allowing the cell to utilize biotin sulfoxide as a biotin source. It reduces a spontaneous oxidation product of biotin, D-biotin D-sulfoxide (BSO or BDS), back to biotin. Also exhibits methionine-(S)-sulfoxide (Met-S-SO) reductase activity, acting specifically on the (S) enantiomer in the free, but not the protein-bound form. It thus plays a role in assimilation of oxidized methionines. {ECO 0000269|PubMed 15601707, ECO 0000269|PubMed 2180922}. # GO_function BISC_ECOLI GO 0033744 L-methionine thioredoxin-disulfide S-oxidoreductase activity; IDA EcoCyc. # GO_function GO:0009055 electron carrier activity; IEA:InterPro. # GO_function GO:0030151 molybdenum ion binding; IMP:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # InterPro IPR006655 Mopterin_OxRdtase_prok_CS # InterPro IPR006656 Mopterin_OxRdtase # InterPro IPR006657 MoPterin_dinucl-bd_dom # InterPro IPR006658 BisC # InterPro IPR009010 Asp_de-COase-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko00780 Biotin metabolism # MISCELLANEOUS BISC_ECOLI Requires a small thioredoxin-like protein for activity. # Organism BISC_ECOLI Escherichia coli (strain K12) # PATRIC 32122574 VBIEscCol129921_3664 # PIR S47772 S47772 # PROSITE PS00490 MOLYBDOPTERIN_PROK_2 # PROSITE PS00932 MOLYBDOPTERIN_PROK_3 # Pfam PF00384 Molybdopterin # Pfam PF01568 Molydop_binding # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BISC_ECOLI Biotin sulfoxide reductase # RefSeq NP_418007 NC_000913.3 # SEQUENCE CAUTION Sequence=AAB18528.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAE77744.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. {ECO 0000305}. # SUPFAM SSF50692 SSF50692 # TCDB 5.A.3.4 the prokaryotic molybdopterin-containing oxidoreductase (pmo) family # TIGRFAMs TIGR00509 bisC_fam # eggNOG COG0243 LUCA # eggNOG ENOG4107QY8 Bacteria BLAST swissprot:BISC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BISC_ECOLI BioCyc ECOL316407:JW5940-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5940-MONOMER BioCyc EcoCyc:EG10124-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10124-MONOMER BioCyc MetaCyc:EG10124-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10124-MONOMER COG COG0243 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0243 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.187.1.231-237.2005 http://dx.doi.org/10.1128/JB.187.1.231-237.2005 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EC_number EC:1.8.4.13 http://www.genome.jp/dbget-bin/www_bget?EC:1.8.4.13 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M34827 http://www.ebi.ac.uk/ena/data/view/M34827 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- ENZYME 1.8.4.13 http://enzyme.expasy.org/EC/1.8.4.13 EchoBASE EB0122 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0122 EcoGene EG10124 http://www.ecogene.org/geneInfo.php?eg_id=EG10124 EnsemblBacteria AAC76575 http://www.ensemblgenomes.org/id/AAC76575 EnsemblBacteria AAC76575 http://www.ensemblgenomes.org/id/AAC76575 EnsemblBacteria BAE77744 http://www.ensemblgenomes.org/id/BAE77744 EnsemblBacteria BAE77744 http://www.ensemblgenomes.org/id/BAE77744 EnsemblBacteria BAE77744 http://www.ensemblgenomes.org/id/BAE77744 EnsemblBacteria b3551 http://www.ensemblgenomes.org/id/b3551 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0030151 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030151 GO_function GO:0033744 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033744 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GeneID 946915 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946915 HOGENOM HOG000284391 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000284391&db=HOGENOM6 InParanoid P20099 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P20099 IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 IntEnz 1.8.4.13 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.8.4.13 InterPro IPR006655 http://www.ebi.ac.uk/interpro/entry/IPR006655 InterPro IPR006656 http://www.ebi.ac.uk/interpro/entry/IPR006656 InterPro IPR006657 http://www.ebi.ac.uk/interpro/entry/IPR006657 InterPro IPR006658 http://www.ebi.ac.uk/interpro/entry/IPR006658 InterPro IPR009010 http://www.ebi.ac.uk/interpro/entry/IPR009010 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5940 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5940 KEGG_Gene eco:b3551 http://www.genome.jp/dbget-bin/www_bget?eco:b3551 KEGG_Orthology KO:K08351 http://www.genome.jp/dbget-bin/www_bget?KO:K08351 KEGG_Pathway ko00780 http://www.genome.jp/kegg-bin/show_pathway?ko00780 KEGG_Reaction rn:R10127 http://www.genome.jp/dbget-bin/www_bget?rn:R10127 OMA LEPDEWH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LEPDEWH PROSITE PS00490 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00490 PROSITE PS00932 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00932 PSORT swissprot:BISC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BISC_ECOLI PSORT-B swissprot:BISC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BISC_ECOLI PSORT2 swissprot:BISC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BISC_ECOLI Pfam PF00384 http://pfam.xfam.org/family/PF00384 Pfam PF01568 http://pfam.xfam.org/family/PF01568 Phobius swissprot:BISC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BISC_ECOLI PhylomeDB P20099 http://phylomedb.org/?seqid=P20099 ProteinModelPortal P20099 http://www.proteinmodelportal.org/query/uniprot/P20099 PubMed 15601707 http://www.ncbi.nlm.nih.gov/pubmed/15601707 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2180922 http://www.ncbi.nlm.nih.gov/pubmed/2180922 PubMed 6460021 http://www.ncbi.nlm.nih.gov/pubmed/6460021 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418007 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418007 SMR P20099 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P20099 STRING 511145.b3551 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3551&targetmode=cogs STRING COG0243 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0243&targetmode=cogs SUPFAM SSF50692 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50692 TCDB 5.A.3.4 http://www.tcdb.org/search/result.php?tc=5.A.3.4 TIGRFAMs TIGR00509 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00509 UniProtKB BISC_ECOLI http://www.uniprot.org/uniprot/BISC_ECOLI UniProtKB-AC P20099 http://www.uniprot.org/uniprot/P20099 charge swissprot:BISC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BISC_ECOLI eggNOG COG0243 http://eggnogapi.embl.de/nog_data/html/tree/COG0243 eggNOG ENOG4107QY8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QY8 epestfind swissprot:BISC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BISC_ECOLI garnier swissprot:BISC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BISC_ECOLI helixturnhelix swissprot:BISC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BISC_ECOLI hmoment swissprot:BISC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BISC_ECOLI iep swissprot:BISC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BISC_ECOLI inforesidue swissprot:BISC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BISC_ECOLI octanol swissprot:BISC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BISC_ECOLI pepcoil swissprot:BISC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BISC_ECOLI pepdigest swissprot:BISC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BISC_ECOLI pepinfo swissprot:BISC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BISC_ECOLI pepnet swissprot:BISC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BISC_ECOLI pepstats swissprot:BISC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BISC_ECOLI pepwheel swissprot:BISC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BISC_ECOLI pepwindow swissprot:BISC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BISC_ECOLI sigcleave swissprot:BISC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BISC_ECOLI ## Database ID URL or Descriptions # AltName METC_ECOLI Beta-cystathionase # AltName METC_ECOLI Cysteine lyase # BRENDA 4.4.1 2026 # BioGrid 4261419 33 # CATALYTIC ACTIVITY METC_ECOLI L-cystathionine + H(2)O = L-homocysteine + NH(3) + pyruvate. # CDD cd00614 CGS_like # COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI 597326; # EcoGene EG10583 metC # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0004121 cystathionine beta-lyase activity; IDA:EcoCyc. # GO_function GO:0030170 pyridoxal phosphate binding; IDA:EcoCyc. # GO_function GO:0080146 L-cysteine desulfhydrase activity; IMP:EcoCyc. # GO_process GO:0006790 sulfur compound metabolic process; IBA:GO_Central. # GO_process GO:0019343 cysteine biosynthetic process via cystathionine; IBA:GO_Central. # GO_process GO:0019346 transsulfuration; IBA:GO_Central. # GO_process GO:0019450 L-cysteine catabolic process to pyruvate; IBA:GO_Central. # GO_process GO:0071266 'de novo' L-methionine biosynthetic process; IBA:GO_Central. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.640.10 -; 1. # Gene3D 3.90.1150.10 -; 1. # IntAct P06721 6 # InterPro IPR000277 Cys/Met-Metab_PyrdxlP-dep_enz # InterPro IPR006233 Cys_b_lyase_bac # InterPro IPR015421 PyrdxlP-dep_Trfase_major_sub1 # InterPro IPR015422 PyrdxlP-dep_Trfase_major_sub2 # InterPro IPR015424 PyrdxlP-dep_Trfase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00270 Cysteine and methionine metabolism # KEGG_Pathway ko00450 Selenocompound metabolism # KEGG_Pathway ko00920 Sulfur metabolism # Organism METC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11808 PTHR11808 # PATHWAY Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from L-cystathionine step 1/1. # PATRIC 32121430 VBIEscCol129921_3102 # PDB 1CL1 X-ray; 1.83 A; A/B=1-395 # PDB 1CL2 X-ray; 2.20 A; A/B=1-395 # PDB 2FQ6 X-ray; 1.78 A; A/B=1-395 # PDB 2GQN X-ray; 1.80 A; A/B=1-395 # PDB 4ITG X-ray; 1.74 A; A/B=1-395 # PDB 4ITX X-ray; 1.61 A; A/B=1-395 # PIR A25153 WZECCB # PIRSF PIRSF001434 CGS # PROSITE PS00868 CYS_MET_METAB_PP # Pfam PF01053 Cys_Met_Meta_PP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName METC_ECOLI Cystathionine beta-lyase MetC # RefSeq NP_417481 NC_000913.3 # RefSeq WP_001301079 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA69175.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the trans-sulfuration enzymes family. {ECO 0000305}. # SUBCELLULAR LOCATION METC_ECOLI Cytoplasm. # SUBUNIT Homotetramer. {ECO:0000269|PubMed 8831789}. # SUPFAM SSF53383 SSF53383 # TIGRFAMs TIGR01324 cysta_beta_ly_B # UniPathway UPA00051 UER00078 # eggNOG COG0626 LUCA # eggNOG ENOG4105C28 Bacteria BLAST swissprot:METC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:METC_ECOLI BioCyc ECOL316407:JW2975-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2975-MONOMER BioCyc EcoCyc:CYSTATHIONINE-BETA-LYASE-MONOMER http://biocyc.org/getid?id=EcoCyc:CYSTATHIONINE-BETA-LYASE-MONOMER BioCyc MetaCyc:CYSTATHIONINE-BETA-LYASE-MONOMER http://biocyc.org/getid?id=MetaCyc:CYSTATHIONINE-BETA-LYASE-MONOMER COG COG0626 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0626 DIP DIP-10193N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10193N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/jmbi.1996.0508 http://dx.doi.org/10.1006/jmbi.1996.0508 DOI 10.1016/0006-291X(87)90968-5 http://dx.doi.org/10.1016/0006-291X(87)90968-5 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.83.4.867 http://dx.doi.org/10.1073/pnas.83.4.867 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.4.1.8 http://www.genome.jp/dbget-bin/www_bget?EC:4.4.1.8 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M12858 http://www.ebi.ac.uk/ena/data/view/M12858 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 ENZYME 4.4.1.8 http://enzyme.expasy.org/EC/4.4.1.8 EchoBASE EB0578 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0578 EcoGene EG10583 http://www.ecogene.org/geneInfo.php?eg_id=EG10583 EnsemblBacteria AAC76044 http://www.ensemblgenomes.org/id/AAC76044 EnsemblBacteria AAC76044 http://www.ensemblgenomes.org/id/AAC76044 EnsemblBacteria BAE77065 http://www.ensemblgenomes.org/id/BAE77065 EnsemblBacteria BAE77065 http://www.ensemblgenomes.org/id/BAE77065 EnsemblBacteria BAE77065 http://www.ensemblgenomes.org/id/BAE77065 EnsemblBacteria b3008 http://www.ensemblgenomes.org/id/b3008 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004121 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004121 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_function GO:0080146 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0080146 GO_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GO_process GO:0019343 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019343 GO_process GO:0019346 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019346 GO_process GO:0019450 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019450 GO_process GO:0071266 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071266 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.640.10 http://www.cathdb.info/version/latest/superfamily/3.40.640.10 Gene3D 3.90.1150.10 http://www.cathdb.info/version/latest/superfamily/3.90.1150.10 GeneID 946240 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946240 HOGENOM HOG000246416 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000246416&db=HOGENOM6 InParanoid P06721 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P06721 IntAct P06721 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P06721* IntEnz 4.4.1.8 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.4.1.8 InterPro IPR000277 http://www.ebi.ac.uk/interpro/entry/IPR000277 InterPro IPR006233 http://www.ebi.ac.uk/interpro/entry/IPR006233 InterPro IPR015421 http://www.ebi.ac.uk/interpro/entry/IPR015421 InterPro IPR015422 http://www.ebi.ac.uk/interpro/entry/IPR015422 InterPro IPR015424 http://www.ebi.ac.uk/interpro/entry/IPR015424 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2975 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2975 KEGG_Gene eco:b3008 http://www.genome.jp/dbget-bin/www_bget?eco:b3008 KEGG_Orthology KO:K01760 http://www.genome.jp/dbget-bin/www_bget?KO:K01760 KEGG_Pathway ko00270 http://www.genome.jp/kegg-bin/show_pathway?ko00270 KEGG_Pathway ko00450 http://www.genome.jp/kegg-bin/show_pathway?ko00450 KEGG_Pathway ko00920 http://www.genome.jp/kegg-bin/show_pathway?ko00920 KEGG_Reaction rn:R00782 http://www.genome.jp/dbget-bin/www_bget?rn:R00782 KEGG_Reaction rn:R01285 http://www.genome.jp/dbget-bin/www_bget?rn:R01285 KEGG_Reaction rn:R01286 http://www.genome.jp/dbget-bin/www_bget?rn:R01286 KEGG_Reaction rn:R02408 http://www.genome.jp/dbget-bin/www_bget?rn:R02408 KEGG_Reaction rn:R04941 http://www.genome.jp/dbget-bin/www_bget?rn:R04941 OMA PTHFAFQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PTHFAFQ PANTHER PTHR11808 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11808 PDB 1CL1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1CL1 PDB 1CL2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1CL2 PDB 2FQ6 http://www.ebi.ac.uk/pdbe-srv/view/entry/2FQ6 PDB 2GQN http://www.ebi.ac.uk/pdbe-srv/view/entry/2GQN PDB 4ITG http://www.ebi.ac.uk/pdbe-srv/view/entry/4ITG PDB 4ITX http://www.ebi.ac.uk/pdbe-srv/view/entry/4ITX PDBsum 1CL1 http://www.ebi.ac.uk/pdbsum/1CL1 PDBsum 1CL2 http://www.ebi.ac.uk/pdbsum/1CL2 PDBsum 2FQ6 http://www.ebi.ac.uk/pdbsum/2FQ6 PDBsum 2GQN http://www.ebi.ac.uk/pdbsum/2GQN PDBsum 4ITG http://www.ebi.ac.uk/pdbsum/4ITG PDBsum 4ITX http://www.ebi.ac.uk/pdbsum/4ITX PROSITE PS00868 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00868 PSORT swissprot:METC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:METC_ECOLI PSORT-B swissprot:METC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:METC_ECOLI PSORT2 swissprot:METC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:METC_ECOLI Pfam PF01053 http://pfam.xfam.org/family/PF01053 Phobius swissprot:METC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:METC_ECOLI PhylomeDB P06721 http://phylomedb.org/?seqid=P06721 ProteinModelPortal P06721 http://www.proteinmodelportal.org/query/uniprot/P06721 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3307782 http://www.ncbi.nlm.nih.gov/pubmed/3307782 PubMed 3513164 http://www.ncbi.nlm.nih.gov/pubmed/3513164 PubMed 8831789 http://www.ncbi.nlm.nih.gov/pubmed/8831789 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417481 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417481 RefSeq WP_001301079 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001301079 SMR P06721 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P06721 STRING 511145.b3008 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3008&targetmode=cogs STRING COG0626 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0626&targetmode=cogs SUPFAM SSF53383 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53383 TIGRFAMs TIGR01324 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01324 UniProtKB METC_ECOLI http://www.uniprot.org/uniprot/METC_ECOLI UniProtKB-AC P06721 http://www.uniprot.org/uniprot/P06721 charge swissprot:METC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:METC_ECOLI eggNOG COG0626 http://eggnogapi.embl.de/nog_data/html/tree/COG0626 eggNOG ENOG4105C28 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C28 epestfind swissprot:METC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:METC_ECOLI garnier swissprot:METC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:METC_ECOLI helixturnhelix swissprot:METC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:METC_ECOLI hmoment swissprot:METC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:METC_ECOLI iep swissprot:METC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:METC_ECOLI inforesidue swissprot:METC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:METC_ECOLI octanol swissprot:METC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:METC_ECOLI pepcoil swissprot:METC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:METC_ECOLI pepdigest swissprot:METC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:METC_ECOLI pepinfo swissprot:METC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:METC_ECOLI pepnet swissprot:METC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:METC_ECOLI pepstats swissprot:METC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:METC_ECOLI pepwheel swissprot:METC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:METC_ECOLI pepwindow swissprot:METC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:METC_ECOLI sigcleave swissprot:METC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:METC_ECOLI ## Database ID URL or Descriptions # BioGrid 4260425 166 # CDD cd06174 MFS # EcoGene EG12136 mdtD # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IEA:UniProtKB-HAMAP. # GO_process GO:0055085 transmembrane transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0055085 transmembrane transport # HAMAP MF_01577 MFS_MdtD # INDUCTION MDTD_ECOLI Transcriptionally regulated by BaeR. {ECO 0000269|PubMed 12107133, ECO 0000269|PubMed 12107134}. # InterPro IPR004638 Drug-R_transpt_efflux_EmrB # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # InterPro IPR023721 Multi-R_MdtD_put # Organism MDTD_ECOLI Escherichia coli (strain K12) # PATRIC 32119487 VBIEscCol129921_2154 # PIR D64974 D64974 # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MDTD_ECOLI Putative multidrug resistance protein MdtD # RefSeq NP_416581 NC_000913.3 # RefSeq WP_000130850 NZ_LN832404.1 # SIMILARITY Belongs to the major facilitator superfamily. TCR/Tet family. {ECO 0000305}. # SUBCELLULAR LOCATION MDTD_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF103473 SSF103473; 2 # TCDB 2.A.1.3.26 the major facilitator superfamily (mfs) # TIGRFAMs TIGR00711 efflux_EmrB # eggNOG ENOG4105C0R Bacteria # eggNOG ENOG410XNN3 LUCA BLAST swissprot:MDTD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MDTD_ECOLI BioCyc ECOL316407:JW2062-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2062-MONOMER BioCyc EcoCyc:B2077-MONOMER http://biocyc.org/getid?id=EcoCyc:B2077-MONOMER DIP DIP-11876N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11876N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.15.4161-4167.2002 http://dx.doi.org/10.1128/JB.184.15.4161-4167.2002 DOI 10.1128/JB.184.15.4168-4176.2002 http://dx.doi.org/10.1128/JB.184.15.4168-4176.2002 EMBL AB089190 http://www.ebi.ac.uk/ena/data/view/AB089190 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D14054 http://www.ebi.ac.uk/ena/data/view/D14054 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2057 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2057 EcoGene EG12136 http://www.ecogene.org/geneInfo.php?eg_id=EG12136 EnsemblBacteria AAC75138 http://www.ensemblgenomes.org/id/AAC75138 EnsemblBacteria AAC75138 http://www.ensemblgenomes.org/id/AAC75138 EnsemblBacteria BAA15933 http://www.ensemblgenomes.org/id/BAA15933 EnsemblBacteria BAA15933 http://www.ensemblgenomes.org/id/BAA15933 EnsemblBacteria BAA15933 http://www.ensemblgenomes.org/id/BAA15933 EnsemblBacteria b2077 http://www.ensemblgenomes.org/id/b2077 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 946601 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946601 HAMAP MF_01577 http://hamap.expasy.org/unirule/MF_01577 HOGENOM HOG000193484 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000193484&db=HOGENOM6 InParanoid P36554 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P36554 IntAct P36554 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P36554* InterPro IPR004638 http://www.ebi.ac.uk/interpro/entry/IPR004638 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 InterPro IPR023721 http://www.ebi.ac.uk/interpro/entry/IPR023721 KEGG_Gene ecj:JW2062 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2062 KEGG_Gene eco:b2077 http://www.genome.jp/dbget-bin/www_bget?eco:b2077 MINT MINT-1320504 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1320504 OMA ALGFFMQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ALGFFMQ PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:MDTD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MDTD_ECOLI PSORT-B swissprot:MDTD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MDTD_ECOLI PSORT2 swissprot:MDTD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MDTD_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:MDTD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MDTD_ECOLI PhylomeDB P36554 http://phylomedb.org/?seqid=P36554 ProteinModelPortal P36554 http://www.proteinmodelportal.org/query/uniprot/P36554 PubMed 12107133 http://www.ncbi.nlm.nih.gov/pubmed/12107133 PubMed 12107134 http://www.ncbi.nlm.nih.gov/pubmed/12107134 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8282725 http://www.ncbi.nlm.nih.gov/pubmed/8282725 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416581 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416581 RefSeq WP_000130850 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000130850 STRING 511145.b2077 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2077&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.3.26 http://www.tcdb.org/search/result.php?tc=2.A.1.3.26 TIGRFAMs TIGR00711 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00711 UniProtKB MDTD_ECOLI http://www.uniprot.org/uniprot/MDTD_ECOLI UniProtKB-AC P36554 http://www.uniprot.org/uniprot/P36554 charge swissprot:MDTD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MDTD_ECOLI eggNOG ENOG4105C0R http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C0R eggNOG ENOG410XNN3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNN3 epestfind swissprot:MDTD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MDTD_ECOLI garnier swissprot:MDTD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MDTD_ECOLI helixturnhelix swissprot:MDTD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MDTD_ECOLI hmoment swissprot:MDTD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MDTD_ECOLI iep swissprot:MDTD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MDTD_ECOLI inforesidue swissprot:MDTD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MDTD_ECOLI octanol swissprot:MDTD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MDTD_ECOLI pepcoil swissprot:MDTD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MDTD_ECOLI pepdigest swissprot:MDTD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MDTD_ECOLI pepinfo swissprot:MDTD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MDTD_ECOLI pepnet swissprot:MDTD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MDTD_ECOLI pepstats swissprot:MDTD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MDTD_ECOLI pepwheel swissprot:MDTD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MDTD_ECOLI pepwindow swissprot:MDTD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MDTD_ECOLI sigcleave swissprot:MDTD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MDTD_ECOLI ## Database ID URL or Descriptions # EcoGene EG10876 rplO # FUNCTION RL15_ECOLI This protein binds the 5S rRNA. It is required for the late stages of subunit assembly, and is essential for 5S rRNA assembly onto the ribosome. {ECO 0000269|PubMed 3298242}. # GO_component GO:0022625 cytosolic large ribosomal subunit; IDA:EcoCyc. # GO_function GO:0003735 structural constituent of ribosome; IBA:GO_Central. # GO_function GO:0019843 rRNA binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006412 translation; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_function GO:0019843 rRNA binding # GOslim_process GO:0006412 translation # HAMAP MF_01341 Ribosomal_L15 # INTERACTION RL15_ECOLI P36979 rlmN; NbExp=3; IntAct=EBI-543017, EBI-559071; # IntAct P02413 78 # InterPro IPR001196 Ribosomal_L15_CS # InterPro IPR005749 Ribosomal_L15_bac-type # InterPro IPR021131 Ribosomal_L18e/L15P # InterPro IPR030878 Ribosomal_L15 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 M00179 Ribosome, archaea # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=14980.1; Method=MALDI; Range=1-144; Evidence={ECO:0000269|PubMed 10094780}; # Organism RL15_ECOLI Escherichia coli (strain K12) # PANTHER PTHR12934 PTHR12934 # PATRIC 32122034 VBIEscCol129921_3394 # PDB 1ML5 EM; 14.00 A; o=2-144 # PDB 2J28 EM; 8.00 A; L=1-144 # PDB 2RDO EM; 9.10 A; L=1-144 # PDB 3BBX EM; 10.00 A; L=1-144 # PDB 3IY9 EM; 14.10 A; L=2-144 # PDB 3J5L EM; 6.60 A; L=2-144 # PDB 3J7Z EM; 3.90 A; L=1-144 # PDB 3J8G EM; 5.00 A; L=1-144 # PDB 3J9Y EM; 3.90 A; L=1-144 # PDB 3J9Z EM; 3.60 A; LH=1-144 # PDB 3JA1 EM; 3.60 A; LN=1-144 # PDB 3JBU EM; 3.64 A; l=1-144 # PDB 3JBV EM; 3.32 A; l=1-144 # PDB 3JCD EM; 3.70 A; L=1-144 # PDB 3JCE EM; 3.20 A; L=1-144 # PDB 3JCJ EM; 3.70 A; K=1-144 # PDB 3JCN EM; 4.60 A; L=1-144 # PDB 4CSU EM; 5.50 A; L=2-144 # PDB 4U1U X-ray; 2.95 A; BL/DL=2-144 # PDB 4U1V X-ray; 3.00 A; BL/DL=2-144 # PDB 4U20 X-ray; 2.90 A; BL/DL=2-144 # PDB 4U24 X-ray; 2.90 A; BL/DL=2-144 # PDB 4U25 X-ray; 2.90 A; BL/DL=2-144 # PDB 4U26 X-ray; 2.80 A; BL/DL=2-144 # PDB 4U27 X-ray; 2.80 A; BL/DL=2-144 # PDB 4UY8 EM; 3.80 A; L=2-144 # PDB 4V47 EM; 12.30 A; AJ=1-144 # PDB 4V48 EM; 11.50 A; AJ=1-144 # PDB 4V4H X-ray; 3.46 A; BL/DL=1-144 # PDB 4V4Q X-ray; 3.46 A; BL/DL=1-144 # PDB 4V4V EM; 15.00 A; BJ=4-143 # PDB 4V4W EM; 15.00 A; BJ=4-143 # PDB 4V50 X-ray; 3.22 A; BL/DL=1-144 # PDB 4V52 X-ray; 3.21 A; BL/DL=1-144 # PDB 4V53 X-ray; 3.54 A; BL/DL=1-144 # PDB 4V54 X-ray; 3.30 A; BL/DL=1-144 # PDB 4V55 X-ray; 4.00 A; BL/DL=1-144 # PDB 4V56 X-ray; 3.93 A; BL/DL=1-144 # PDB 4V57 X-ray; 3.50 A; BL/DL=1-144 # PDB 4V5B X-ray; 3.74 A; AL/CL=1-144 # PDB 4V5H EM; 5.80 A; BL=2-144 # PDB 4V5Y X-ray; 4.45 A; BL/DL=1-144 # PDB 4V64 X-ray; 3.50 A; BL/DL=1-144 # PDB 4V65 EM; 9.00 A; BE=1-144 # PDB 4V66 EM; 9.00 A; BE=1-144 # PDB 4V69 EM; 6.70 A; BL=2-144 # PDB 4V6C X-ray; 3.19 A; BL/DL=1-144 # PDB 4V6D X-ray; 3.81 A; BL/DL=1-144 # PDB 4V6E X-ray; 3.71 A; BL/DL=1-144 # PDB 4V6K EM; 8.25 A; AM=1-144 # PDB 4V6L EM; 13.20 A; BM=1-144 # PDB 4V6M EM; 7.10 A; BL=1-144 # PDB 4V6N EM; 12.10 A; AN=1-144 # PDB 4V6O EM; 14.70 A; BN=1-144 # PDB 4V6P EM; 13.50 A; BN=1-144 # PDB 4V6Q EM; 11.50 A; BN=1-144 # PDB 4V6R EM; 11.50 A; BN=1-144 # PDB 4V6S EM; 13.10 A; AN=1-144 # PDB 4V6T EM; 8.30 A; BL=2-144 # PDB 4V6V EM; 9.80 A; BP=1-144 # PDB 4V6Y EM; 12.00 A; BL=1-144 # PDB 4V6Z EM; 12.00 A; BL=1-144 # PDB 4V70 EM; 17.00 A; BL=1-144 # PDB 4V71 EM; 20.00 A; BL=1-144 # PDB 4V72 EM; 13.00 A; BL=1-144 # PDB 4V73 EM; 15.00 A; BL=1-144 # PDB 4V74 EM; 17.00 A; BL=1-144 # PDB 4V75 EM; 12.00 A; BL=1-144 # PDB 4V76 EM; 17.00 A; BL=1-144 # PDB 4V77 EM; 17.00 A; BL=1-144 # PDB 4V78 EM; 20.00 A; BL=1-144 # PDB 4V79 EM; 15.00 A; BL=1-144 # PDB 4V7A EM; 9.00 A; BL=1-144 # PDB 4V7B EM; 6.80 A; BL=1-144 # PDB 4V7C EM; 7.60 A; BN=1-144 # PDB 4V7D EM; 7.60 A; AO=1-144 # PDB 4V7I EM; 9.60 A; AL=1-144 # PDB 4V7S X-ray; 3.25 A; BL/DL=2-144 # PDB 4V7T X-ray; 3.19 A; BL/DL=2-144 # PDB 4V7U X-ray; 3.10 A; BL/DL=2-144 # PDB 4V7V X-ray; 3.29 A; BL/DL=2-144 # PDB 4V85 X-ray; 3.20 A; P=1-144 # PDB 4V89 X-ray; 3.70 A; BP=1-144 # PDB 4V9C X-ray; 3.30 A; BL/DL=1-144 # PDB 4V9D X-ray; 3.00 A; CL/DL=2-144 # PDB 4V9O X-ray; 2.90 A; AL/CL/EL/GL=1-144 # PDB 4V9P X-ray; 2.90 A; AL/CL/EL/GL=1-144 # PDB 4WF1 X-ray; 3.09 A; BL/DL=2-144 # PDB 4WOI X-ray; 3.00 A; BL/CL=1-144 # PDB 4WWW X-ray; 3.10 A; RL/YL=2-144 # PDB 4YBB X-ray; 2.10 A; CM/DM=1-144 # PDB 5ADY EM; 4.50 A; L=1-144 # PDB 5AFI EM; 2.90 A; L=1-144 # PDB 5AKA EM; 5.70 A; L=1-144 # PDB 5GAD EM; 3.70 A; M=1-144 # PDB 5GAE EM; 3.33 A; M=1-144 # PDB 5GAF EM; 4.30 A; M=1-144 # PDB 5GAG EM; 3.80 A; M=1-144 # PDB 5GAH EM; 3.80 A; M=1-144 # PDB 5IQR EM; 3.00 A; L=1-144 # PDB 5IT8 X-ray; 3.12 A; CM/DM=1-144 # PDB 5J5B X-ray; 2.80 A; CM/DM=1-144 # PDB 5J7L X-ray; 3.00 A; CM/DM=1-144 # PDB 5J88 X-ray; 3.32 A; CM/DM=1-144 # PDB 5J8A X-ray; 3.10 A; CM/DM=1-144 # PDB 5J91 X-ray; 2.96 A; CM/DM=1-144 # PDB 5JC9 X-ray; 3.03 A; CM/DM=1-144 # PDB 5JTE EM; 3.60 A; BL=1-144 # PDB 5JU8 EM; 3.60 A; BL=1-144 # PDB 5KCR EM; 3.60 A; 1P=1-144 # PDB 5KCS EM; 3.90 A; 1P=1-144 # PDB 5KPS EM; 3.90 A; L=1-144 # PDB 5KPV EM; 4.10 A; K=1-144 # PDB 5KPW EM; 3.90 A; K=1-144 # PDB 5KPX EM; 3.90 A; K=1-144 # PDB 5L3P EM; 3.70 A; P=1-144 # PIR A02794 R5EC15 # PROSITE PS00475 RIBOSOMAL_L15 # Pfam PF00828 Ribosomal_L27A # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RL15_ECOLI 50S ribosomal protein L15 # RefSeq NP_417760 NC_000913.3 # RefSeq WP_001238914 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein L15P family. {ECO 0000305}. # SUBUNIT Part of the 50S ribosomal subunit. Contacts the 5S rRNA. {ECO:0000269|PubMed 3298242}. # SUPFAM SSF52080 SSF52080 # TIGRFAMs TIGR01071 rplO_bact # eggNOG COG0200 LUCA # eggNOG ENOG4108UZ0 Bacteria BLAST swissprot:RL15_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RL15_ECOLI BioCyc ECOL316407:JW3263-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3263-MONOMER BioCyc EcoCyc:EG10876-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10876-MONOMER BioCyc MetaCyc:EG10876-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10876-MONOMER COG COG0200 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0200 DIP DIP-10752N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10752N DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1016/0014-5793(77)80722-9 http://dx.doi.org/10.1016/0014-5793(77)80722-9 DOI 10.1016/S0092-8674(03)00427-6 http://dx.doi.org/10.1016/S0092-8674(03)00427-6 DOI 10.1016/j.celrep.2014.09.011 http://dx.doi.org/10.1016/j.celrep.2014.09.011 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/11.9.2599 http://dx.doi.org/10.1093/nar/11.9.2599 DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pbio.1001866 http://dx.doi.org/10.1371/journal.pbio.1001866 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X01563 http://www.ebi.ac.uk/ena/data/view/X01563 EchoBASE EB0869 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0869 EcoGene EG10876 http://www.ecogene.org/geneInfo.php?eg_id=EG10876 EnsemblBacteria AAC76326 http://www.ensemblgenomes.org/id/AAC76326 EnsemblBacteria AAC76326 http://www.ensemblgenomes.org/id/AAC76326 EnsemblBacteria BAE77990 http://www.ensemblgenomes.org/id/BAE77990 EnsemblBacteria BAE77990 http://www.ensemblgenomes.org/id/BAE77990 EnsemblBacteria BAE77990 http://www.ensemblgenomes.org/id/BAE77990 EnsemblBacteria b3301 http://www.ensemblgenomes.org/id/b3301 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0022625 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022625 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GeneID 947798 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947798 HAMAP MF_01341 http://hamap.expasy.org/unirule/MF_01341 HOGENOM HOG000231262 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231262&db=HOGENOM6 InParanoid P02413 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P02413 IntAct P02413 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P02413* InterPro IPR001196 http://www.ebi.ac.uk/interpro/entry/IPR001196 InterPro IPR005749 http://www.ebi.ac.uk/interpro/entry/IPR005749 InterPro IPR021131 http://www.ebi.ac.uk/interpro/entry/IPR021131 InterPro IPR030878 http://www.ebi.ac.uk/interpro/entry/IPR030878 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW3263 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3263 KEGG_Gene eco:b3301 http://www.genome.jp/dbget-bin/www_bget?eco:b3301 KEGG_Orthology KO:K02876 http://www.genome.jp/dbget-bin/www_bget?KO:K02876 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 MINT MINT-1260355 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1260355 OMA RGHKGLK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RGHKGLK PANTHER PTHR12934 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12934 PDB 1ML5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ML5 PDB 2J28 http://www.ebi.ac.uk/pdbe-srv/view/entry/2J28 PDB 2RDO http://www.ebi.ac.uk/pdbe-srv/view/entry/2RDO PDB 3BBX http://www.ebi.ac.uk/pdbe-srv/view/entry/3BBX PDB 3IY9 http://www.ebi.ac.uk/pdbe-srv/view/entry/3IY9 PDB 3J5L http://www.ebi.ac.uk/pdbe-srv/view/entry/3J5L PDB 3J7Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J7Z PDB 3J8G http://www.ebi.ac.uk/pdbe-srv/view/entry/3J8G PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 4CSU http://www.ebi.ac.uk/pdbe-srv/view/entry/4CSU PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4UY8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4UY8 PDB 4V47 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V47 PDB 4V48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V48 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5ADY http://www.ebi.ac.uk/pdbe-srv/view/entry/5ADY PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5AKA http://www.ebi.ac.uk/pdbe-srv/view/entry/5AKA PDB 5GAD http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAD PDB 5GAE http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAE PDB 5GAF http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAF PDB 5GAG http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAG PDB 5GAH http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAH PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 1ML5 http://www.ebi.ac.uk/pdbsum/1ML5 PDBsum 2J28 http://www.ebi.ac.uk/pdbsum/2J28 PDBsum 2RDO http://www.ebi.ac.uk/pdbsum/2RDO PDBsum 3BBX http://www.ebi.ac.uk/pdbsum/3BBX PDBsum 3IY9 http://www.ebi.ac.uk/pdbsum/3IY9 PDBsum 3J5L http://www.ebi.ac.uk/pdbsum/3J5L PDBsum 3J7Z http://www.ebi.ac.uk/pdbsum/3J7Z PDBsum 3J8G http://www.ebi.ac.uk/pdbsum/3J8G PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 4CSU http://www.ebi.ac.uk/pdbsum/4CSU PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4UY8 http://www.ebi.ac.uk/pdbsum/4UY8 PDBsum 4V47 http://www.ebi.ac.uk/pdbsum/4V47 PDBsum 4V48 http://www.ebi.ac.uk/pdbsum/4V48 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5ADY http://www.ebi.ac.uk/pdbsum/5ADY PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5AKA http://www.ebi.ac.uk/pdbsum/5AKA PDBsum 5GAD http://www.ebi.ac.uk/pdbsum/5GAD PDBsum 5GAE http://www.ebi.ac.uk/pdbsum/5GAE PDBsum 5GAF http://www.ebi.ac.uk/pdbsum/5GAF PDBsum 5GAG http://www.ebi.ac.uk/pdbsum/5GAG PDBsum 5GAH http://www.ebi.ac.uk/pdbsum/5GAH PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PROSITE PS00475 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00475 PSORT swissprot:RL15_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RL15_ECOLI PSORT-B swissprot:RL15_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RL15_ECOLI PSORT2 swissprot:RL15_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RL15_ECOLI Pfam PF00828 http://pfam.xfam.org/family/PF00828 Phobius swissprot:RL15_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RL15_ECOLI PhylomeDB P02413 http://phylomedb.org/?seqid=P02413 ProteinModelPortal P02413 http://www.proteinmodelportal.org/query/uniprot/P02413 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 12809609 http://www.ncbi.nlm.nih.gov/pubmed/12809609 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 24844575 http://www.ncbi.nlm.nih.gov/pubmed/24844575 PubMed 25310980 http://www.ncbi.nlm.nih.gov/pubmed/25310980 PubMed 3298242 http://www.ncbi.nlm.nih.gov/pubmed/3298242 PubMed 340263 http://www.ncbi.nlm.nih.gov/pubmed/340263 PubMed 6222285 http://www.ncbi.nlm.nih.gov/pubmed/6222285 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417760 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417760 RefSeq WP_001238914 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001238914 SMR P02413 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P02413 STRING 511145.b3301 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3301&targetmode=cogs STRING COG0200 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0200&targetmode=cogs SUPFAM SSF52080 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52080 TIGRFAMs TIGR01071 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01071 UniProtKB RL15_ECOLI http://www.uniprot.org/uniprot/RL15_ECOLI UniProtKB-AC P02413 http://www.uniprot.org/uniprot/P02413 charge swissprot:RL15_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RL15_ECOLI eggNOG COG0200 http://eggnogapi.embl.de/nog_data/html/tree/COG0200 eggNOG ENOG4108UZ0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UZ0 epestfind swissprot:RL15_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RL15_ECOLI garnier swissprot:RL15_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RL15_ECOLI helixturnhelix swissprot:RL15_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RL15_ECOLI hmoment swissprot:RL15_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RL15_ECOLI iep swissprot:RL15_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RL15_ECOLI inforesidue swissprot:RL15_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RL15_ECOLI octanol swissprot:RL15_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RL15_ECOLI pepcoil swissprot:RL15_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RL15_ECOLI pepdigest swissprot:RL15_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RL15_ECOLI pepinfo swissprot:RL15_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RL15_ECOLI pepnet swissprot:RL15_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RL15_ECOLI pepstats swissprot:RL15_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RL15_ECOLI pepwheel swissprot:RL15_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RL15_ECOLI pepwindow swissprot:RL15_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RL15_ECOLI sigcleave swissprot:RL15_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RL15_ECOLI ## Database ID URL or Descriptions # BioGrid 4262531 218 # EcoGene EG12266 yhjV # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0003333 amino acid transmembrane transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0055085 transmembrane transport # InterPro IPR018227 Tryptophan/tyrosine_permease # Organism YHJV_ECOLI Escherichia coli (strain K12) # PATRIC 32122546 VBIEscCol129921_3651 # PIR S47761 S47761 # Pfam PF03222 Trp_Tyr_perm # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHJV_ECOLI Inner membrane transport protein YhjV # RefSeq NP_417996 NC_000913.3 # RefSeq WP_001295225 NZ_LN832404.1 # SIMILARITY Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION YHJV_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.42.2 the hydroxy/aromatic amino acid permease (haaap) family # eggNOG COG0814 LUCA # eggNOG ENOG4105C44 Bacteria BLAST swissprot:YHJV_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHJV_ECOLI BioCyc ECOL316407:JW3508-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3508-MONOMER BioCyc EcoCyc:YHJV-MONOMER http://biocyc.org/getid?id=EcoCyc:YHJV-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2175 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2175 EcoGene EG12266 http://www.ecogene.org/geneInfo.php?eg_id=EG12266 EnsemblBacteria AAC76564 http://www.ensemblgenomes.org/id/AAC76564 EnsemblBacteria AAC76564 http://www.ensemblgenomes.org/id/AAC76564 EnsemblBacteria BAE77755 http://www.ensemblgenomes.org/id/BAE77755 EnsemblBacteria BAE77755 http://www.ensemblgenomes.org/id/BAE77755 EnsemblBacteria BAE77755 http://www.ensemblgenomes.org/id/BAE77755 EnsemblBacteria b3539 http://www.ensemblgenomes.org/id/b3539 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0003333 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003333 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 948057 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948057 HOGENOM HOG000275613 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275613&db=HOGENOM6 InterPro IPR018227 http://www.ebi.ac.uk/interpro/entry/IPR018227 KEGG_Gene ecj:JW3508 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3508 KEGG_Gene eco:b3539 http://www.genome.jp/dbget-bin/www_bget?eco:b3539 OMA YSFLRGR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YSFLRGR PSORT swissprot:YHJV_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHJV_ECOLI PSORT-B swissprot:YHJV_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHJV_ECOLI PSORT2 swissprot:YHJV_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHJV_ECOLI Pfam PF03222 http://pfam.xfam.org/family/PF03222 Phobius swissprot:YHJV_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHJV_ECOLI PhylomeDB P37660 http://phylomedb.org/?seqid=P37660 ProteinModelPortal P37660 http://www.proteinmodelportal.org/query/uniprot/P37660 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417996 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417996 RefSeq WP_001295225 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295225 STRING 511145.b3539 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3539&targetmode=cogs TCDB 2.A.42.2 http://www.tcdb.org/search/result.php?tc=2.A.42.2 UniProtKB YHJV_ECOLI http://www.uniprot.org/uniprot/YHJV_ECOLI UniProtKB-AC P37660 http://www.uniprot.org/uniprot/P37660 charge swissprot:YHJV_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHJV_ECOLI eggNOG COG0814 http://eggnogapi.embl.de/nog_data/html/tree/COG0814 eggNOG ENOG4105C44 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C44 epestfind swissprot:YHJV_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHJV_ECOLI garnier swissprot:YHJV_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHJV_ECOLI helixturnhelix swissprot:YHJV_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHJV_ECOLI hmoment swissprot:YHJV_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHJV_ECOLI iep swissprot:YHJV_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHJV_ECOLI inforesidue swissprot:YHJV_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHJV_ECOLI octanol swissprot:YHJV_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHJV_ECOLI pepcoil swissprot:YHJV_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHJV_ECOLI pepdigest swissprot:YHJV_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHJV_ECOLI pepinfo swissprot:YHJV_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHJV_ECOLI pepnet swissprot:YHJV_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHJV_ECOLI pepstats swissprot:YHJV_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHJV_ECOLI pepwheel swissprot:YHJV_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHJV_ECOLI pepwindow swissprot:YHJV_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHJV_ECOLI sigcleave swissprot:YHJV_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHJV_ECOLI ## Database ID URL or Descriptions # AltName tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmL {ECO:0000255|HAMAP-Rule MF_01885} # BRENDA 2.1.1.207 2026 # BioGrid 4262552 10 # CATALYTIC ACTIVITY TRML_ECOLI S-adenosyl-L-methionine + 5- carboxymethylaminomethyluridine(34) in tRNA(Leu) = S-adenosyl-L- homocysteine + 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu). {ECO 0000255|HAMAP-Rule MF_01885, ECO 0000269|PubMed 20855540}. # CATALYTIC ACTIVITY TRML_ECOLI S-adenosyl-L-methionine + cytidine(34) in tRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine(34) in tRNA. {ECO 0000255|HAMAP-Rule MF_01885, ECO 0000269|PubMed 20855540}. # CAUTION Possibly identical to GltE. {ECO 0000305}. # EcoGene EG11888 trmL # FUNCTION TRML_ECOLI Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide. Recognition of the target requires a pyridine at position 34 and N(6)-(isopentenyl)-2-methylthioadenosine at position 37. {ECO 0000255|HAMAP-Rule MF_01885, ECO 0000269|PubMed 20855540}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003723 RNA binding; IBA:GO_Central. # GO_function GO:0052665 tRNA (uracil-2'-O-)-methyltransferase activity; IDA:EcoCyc. # GO_function GO:0052666 tRNA (cytosine-2'-O-)-methyltransferase activity; IDA:EcoCyc. # GO_process GO:0002131 wobble position cytosine ribose methylation; IMP:EcoCyc. # GO_process GO:0002132 wobble position uridine ribose methylation; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0006399 tRNA metabolic process # Gene3D 3.40.1280.10 -; 1. # HAMAP MF_01885 tRNA_methyltr_TrmL # IntAct P0AGJ7 7 # InterPro IPR001537 SpoU_MeTrfase # InterPro IPR016914 tRNA_cyt/urid_MeTfrase # InterPro IPR029026 tRNA_m1G_MTases_N # InterPro IPR029028 Alpha/beta_knot_MTases # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # Organism TRML_ECOLI Escherichia coli (strain K12) # PATRIC 32122697 VBIEscCol129921_3725 # PDB 4JAK X-ray; 2.00 A; A/B=2-157 # PDB 4JAL X-ray; 2.00 A; A/B=2-157 # PIR S47827 S47827 # PIRSF PIRSF029256 SpoU_TrmH_prd # Pfam PF00588 SpoU_methylase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName tRNA (cytidine(34)-2'-O)-methyltransferase {ECO:0000255|HAMAP-Rule MF_01885} # RefSeq NP_418063 NC_000913.3 # RefSeq WP_000932347 NZ_LN832404.1 # SIMILARITY Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily. {ECO:0000255|HAMAP-Rule MF_01885}. # SUBCELLULAR LOCATION TRML_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_01885}. # SUBUNIT TRML_ECOLI Homodimer. {ECO 0000255|HAMAP-Rule MF_01885, ECO 0000269|PubMed 20855540}. # SUPFAM SSF75217 SSF75217 # TIGRFAMs TIGR00185 tRNA_yibK_trmL # eggNOG COG0219 LUCA # eggNOG ENOG4108UIQ Bacteria BLAST swissprot:TRML_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRML_ECOLI BioCyc ECOL316407:JW3581-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3581-MONOMER BioCyc EcoCyc:EG11888-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11888-MONOMER BioCyc MetaCyc:EG11888-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11888-MONOMER COG COG0219 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0219 DOI 10.1016/0006-291X(90)90615-T http://dx.doi.org/10.1016/0006-291X(90)90615-T DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5519 http://dx.doi.org/10.1093/nar/21.23.5519 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1261/rna.2245910 http://dx.doi.org/10.1261/rna.2245910 EC_number EC:2.1.1.207 {ECO:0000255|HAMAP-Rule:MF_01885} http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.207 {ECO:0000255|HAMAP-Rule:MF_01885} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L13970 http://www.ebi.ac.uk/ena/data/view/L13970 EMBL M34333 http://www.ebi.ac.uk/ena/data/view/M34333 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.1.1.207 {ECO:0000255|HAMAP-Rule:MF_01885} http://enzyme.expasy.org/EC/2.1.1.207 {ECO:0000255|HAMAP-Rule:MF_01885} EchoBASE EB1834 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1834 EcoGene EG11888 http://www.ecogene.org/geneInfo.php?eg_id=EG11888 EnsemblBacteria AAC76630 http://www.ensemblgenomes.org/id/AAC76630 EnsemblBacteria AAC76630 http://www.ensemblgenomes.org/id/AAC76630 EnsemblBacteria BAE77686 http://www.ensemblgenomes.org/id/BAE77686 EnsemblBacteria BAE77686 http://www.ensemblgenomes.org/id/BAE77686 EnsemblBacteria BAE77686 http://www.ensemblgenomes.org/id/BAE77686 EnsemblBacteria b3606 http://www.ensemblgenomes.org/id/b3606 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0052665 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052665 GO_function GO:0052666 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052666 GO_process GO:0002131 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002131 GO_process GO:0002132 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002132 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 Gene3D 3.40.1280.10 http://www.cathdb.info/version/latest/superfamily/3.40.1280.10 GeneID 948119 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948119 HAMAP MF_01885 http://hamap.expasy.org/unirule/MF_01885 HOGENOM HOG000272757 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000272757&db=HOGENOM6 InParanoid P0AGJ7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGJ7 IntAct P0AGJ7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AGJ7* IntEnz 2.1.1.207 {ECO:0000255|HAMAP-Rule:MF_01885} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.207 {ECO:0000255|HAMAP-Rule:MF_01885} InterPro IPR001537 http://www.ebi.ac.uk/interpro/entry/IPR001537 InterPro IPR016914 http://www.ebi.ac.uk/interpro/entry/IPR016914 InterPro IPR029026 http://www.ebi.ac.uk/interpro/entry/IPR029026 InterPro IPR029028 http://www.ebi.ac.uk/interpro/entry/IPR029028 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW3581 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3581 KEGG_Gene eco:b3606 http://www.genome.jp/dbget-bin/www_bget?eco:b3606 KEGG_Orthology KO:K03216 http://www.genome.jp/dbget-bin/www_bget?KO:K03216 MINT MINT-1308881 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1308881 OMA AGLDYWH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AGLDYWH PDB 4JAK http://www.ebi.ac.uk/pdbe-srv/view/entry/4JAK PDB 4JAL http://www.ebi.ac.uk/pdbe-srv/view/entry/4JAL PDBsum 4JAK http://www.ebi.ac.uk/pdbsum/4JAK PDBsum 4JAL http://www.ebi.ac.uk/pdbsum/4JAL PSORT swissprot:TRML_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRML_ECOLI PSORT-B swissprot:TRML_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRML_ECOLI PSORT2 swissprot:TRML_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRML_ECOLI Pfam PF00588 http://pfam.xfam.org/family/PF00588 Phobius swissprot:TRML_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRML_ECOLI PhylomeDB P0AGJ7 http://phylomedb.org/?seqid=P0AGJ7 ProteinModelPortal P0AGJ7 http://www.proteinmodelportal.org/query/uniprot/P0AGJ7 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20855540 http://www.ncbi.nlm.nih.gov/pubmed/20855540 PubMed 2108679 http://www.ncbi.nlm.nih.gov/pubmed/2108679 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 8265370 http://www.ncbi.nlm.nih.gov/pubmed/8265370 PubMed 8407843 http://www.ncbi.nlm.nih.gov/pubmed/8407843 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418063 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418063 RefSeq WP_000932347 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000932347 SMR P0AGJ7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AGJ7 STRING 511145.b3606 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3606&targetmode=cogs STRING COG0219 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0219&targetmode=cogs SUPFAM SSF75217 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF75217 TIGRFAMs TIGR00185 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00185 UniProtKB TRML_ECOLI http://www.uniprot.org/uniprot/TRML_ECOLI UniProtKB-AC P0AGJ7 http://www.uniprot.org/uniprot/P0AGJ7 charge swissprot:TRML_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRML_ECOLI eggNOG COG0219 http://eggnogapi.embl.de/nog_data/html/tree/COG0219 eggNOG ENOG4108UIQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UIQ epestfind swissprot:TRML_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRML_ECOLI garnier swissprot:TRML_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRML_ECOLI helixturnhelix swissprot:TRML_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRML_ECOLI hmoment swissprot:TRML_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRML_ECOLI iep swissprot:TRML_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRML_ECOLI inforesidue swissprot:TRML_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRML_ECOLI octanol swissprot:TRML_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRML_ECOLI pepcoil swissprot:TRML_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRML_ECOLI pepdigest swissprot:TRML_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRML_ECOLI pepinfo swissprot:TRML_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRML_ECOLI pepnet swissprot:TRML_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRML_ECOLI pepstats swissprot:TRML_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRML_ECOLI pepwheel swissprot:TRML_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRML_ECOLI pepwindow swissprot:TRML_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRML_ECOLI sigcleave swissprot:TRML_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRML_ECOLI ## Database ID URL or Descriptions # AltName PNTB_ECOLI Nicotinamide nucleotide transhydrogenase subunit beta # AltName PNTB_ECOLI Pyridine nucleotide transhydrogenase subunit beta # BioGrid 4259125 16 # CATALYTIC ACTIVITY PNTB_ECOLI NADPH + NAD(+) = NADP(+) + NADH. # EcoGene EG10745 pntB # FUNCTION PNTB_ECOLI The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_function GO:0008746 NAD(P)+ transhydrogenase activity; IDA:EcoCyc. # GO_function GO:0008750 NAD(P)+ transhydrogenase (AB-specific) activity; IDA:EcoCyc. # GO_function GO:0050661 NADP binding; IDA:EcoCyc. # GO_process GO:0006740 NADPH regeneration; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.1220 -; 1. # InterPro IPR012136 NADH_DH_b # InterPro IPR029035 DHS-like_NAD/FAD-binding_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00760 Nicotinate and nicotinamide metabolism # Organism PNTB_ECOLI Escherichia coli (strain K12) # PATRIC 32118506 VBIEscCol129921_1673 # PDB 2BRU NMR; -; C=286-462 # PIR S24381 DEECXB # PIRSF PIRSF000204 PNTB # Pfam PF02233 PNTB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PNTB_ECOLI NAD(P) transhydrogenase subunit beta # RefSeq NP_416119 NC_000913.3 # RefSeq WP_000014036 NZ_LN832404.1 # SIMILARITY Belongs to the PNT beta subunit family. {ECO 0000305}. # SUBCELLULAR LOCATION PNTB_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT PNTB_ECOLI Heterodimer of an alpha and a beta chain. # SUPFAM SSF52467 SSF52467 # TCDB 3.D.2.1 the proton-translocating transhydrogenase (pth) family # eggNOG COG1282 LUCA # eggNOG ENOG4105C15 Bacteria BLAST swissprot:PNTB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PNTB_ECOLI BioCyc ECOL316407:JW1594-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1594-MONOMER BioCyc EcoCyc:PNTB-MONOMER http://biocyc.org/getid?id=EcoCyc:PNTB-MONOMER BioCyc MetaCyc:PNTB-MONOMER http://biocyc.org/getid?id=MetaCyc:PNTB-MONOMER COG COG1282 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1282 DIP DIP-367N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-367N DOI 10.1016/0167-4838(91)90106-A http://dx.doi.org/10.1016/0167-4838(91)90106-A DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1111/j.1432-1033.1986.tb09802.x http://dx.doi.org/10.1111/j.1432-1033.1986.tb09802.x DOI 10.1111/j.1432-1033.1992.tb17103.x http://dx.doi.org/10.1111/j.1432-1033.1992.tb17103.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.6.1.2 http://www.genome.jp/dbget-bin/www_bget?EC:1.6.1.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X04195 http://www.ebi.ac.uk/ena/data/view/X04195 EMBL X66086 http://www.ebi.ac.uk/ena/data/view/X66086 ENZYME 1.6.1.2 http://enzyme.expasy.org/EC/1.6.1.2 EchoBASE EB0738 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0738 EcoGene EG10745 http://www.ecogene.org/geneInfo.php?eg_id=EG10745 EnsemblBacteria AAC74674 http://www.ensemblgenomes.org/id/AAC74674 EnsemblBacteria AAC74674 http://www.ensemblgenomes.org/id/AAC74674 EnsemblBacteria BAA15336 http://www.ensemblgenomes.org/id/BAA15336 EnsemblBacteria BAA15336 http://www.ensemblgenomes.org/id/BAA15336 EnsemblBacteria BAA15336 http://www.ensemblgenomes.org/id/BAA15336 EnsemblBacteria b1602 http://www.ensemblgenomes.org/id/b1602 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0008746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008746 GO_function GO:0008750 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008750 GO_function GO:0050661 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050661 GO_process GO:0006740 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006740 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.1220 http://www.cathdb.info/version/latest/superfamily/3.40.50.1220 GeneID 946144 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946144 HOGENOM HOG000243958 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000243958&db=HOGENOM6 InParanoid P0AB67 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AB67 IntEnz 1.6.1.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.6.1.2 InterPro IPR012136 http://www.ebi.ac.uk/interpro/entry/IPR012136 InterPro IPR029035 http://www.ebi.ac.uk/interpro/entry/IPR029035 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1594 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1594 KEGG_Gene eco:b1602 http://www.genome.jp/dbget-bin/www_bget?eco:b1602 KEGG_Orthology KO:K00325 http://www.genome.jp/dbget-bin/www_bget?KO:K00325 KEGG_Pathway ko00760 http://www.genome.jp/kegg-bin/show_pathway?ko00760 KEGG_Reaction rn:R00112 http://www.genome.jp/dbget-bin/www_bget?rn:R00112 OMA HHAEVFI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HHAEVFI PDB 2BRU http://www.ebi.ac.uk/pdbe-srv/view/entry/2BRU PDBsum 2BRU http://www.ebi.ac.uk/pdbsum/2BRU PSORT swissprot:PNTB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PNTB_ECOLI PSORT-B swissprot:PNTB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PNTB_ECOLI PSORT2 swissprot:PNTB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PNTB_ECOLI Pfam PF02233 http://pfam.xfam.org/family/PF02233 Phobius swissprot:PNTB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PNTB_ECOLI PhylomeDB P0AB67 http://phylomedb.org/?seqid=P0AB67 ProteinModelPortal P0AB67 http://www.proteinmodelportal.org/query/uniprot/P0AB67 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 1633824 http://www.ncbi.nlm.nih.gov/pubmed/1633824 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1932078 http://www.ncbi.nlm.nih.gov/pubmed/1932078 PubMed 3525165 http://www.ncbi.nlm.nih.gov/pubmed/3525165 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416119 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416119 RefSeq WP_000014036 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000014036 SMR P0AB67 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AB67 STRING 511145.b1602 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1602&targetmode=cogs STRING COG1282 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1282&targetmode=cogs SUPFAM SSF52467 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52467 TCDB 3.D.2.1 http://www.tcdb.org/search/result.php?tc=3.D.2.1 UniProtKB PNTB_ECOLI http://www.uniprot.org/uniprot/PNTB_ECOLI UniProtKB-AC P0AB67 http://www.uniprot.org/uniprot/P0AB67 charge swissprot:PNTB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PNTB_ECOLI eggNOG COG1282 http://eggnogapi.embl.de/nog_data/html/tree/COG1282 eggNOG ENOG4105C15 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C15 epestfind swissprot:PNTB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PNTB_ECOLI garnier swissprot:PNTB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PNTB_ECOLI helixturnhelix swissprot:PNTB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PNTB_ECOLI hmoment swissprot:PNTB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PNTB_ECOLI iep swissprot:PNTB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PNTB_ECOLI inforesidue swissprot:PNTB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PNTB_ECOLI octanol swissprot:PNTB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PNTB_ECOLI pepcoil swissprot:PNTB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PNTB_ECOLI pepdigest swissprot:PNTB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PNTB_ECOLI pepinfo swissprot:PNTB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PNTB_ECOLI pepnet swissprot:PNTB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PNTB_ECOLI pepstats swissprot:PNTB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PNTB_ECOLI pepwheel swissprot:PNTB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PNTB_ECOLI pepwindow swissprot:PNTB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PNTB_ECOLI sigcleave swissprot:PNTB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PNTB_ECOLI ## Database ID URL or Descriptions # BRENDA 3.1.2 2026 # BioGrid 4259532 2 # ESTHER ecoli-ypfh LYsophospholipase_carboxylesterase # EcoGene EG14195 ypfH # FUNCTION YPFH_ECOLI Displays esterase activity toward palmitoyl-CoA and pNP- butyrate. {ECO 0000269|PubMed 15808744}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0008474 palmitoyl-(protein) hydrolase activity; IBA:GO_Central. # GO_function GO:0016788 hydrolase activity, acting on ester bonds; IDA:EcoliWiki. # GO_function GO:0052689 carboxylic ester hydrolase activity; IDA:EcoCyc. # GO_process GO:0002084 protein depalmitoylation; IBA:GO_Central. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0009056 catabolic process # Gene3D 3.40.50.1820 -; 1. # InterPro IPR003140 PLipase/COase/thioEstase # InterPro IPR029058 AB_hydrolase # Organism YPFH_ECOLI Escherichia coli (strain K12) # PATRIC 32120331 VBIEscCol129921_2568 # PIR H65022 H65022 # Pfam PF02230 Abhydrolase_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YPFH_ECOLI Esterase YpfH # RefSeq NP_416968 NC_000913.3 # RefSeq WP_000679799 NZ_LN832404.1 # SIMILARITY Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. {ECO 0000305}. # SUPFAM SSF53474 SSF53474 # eggNOG COG0400 LUCA # eggNOG ENOG4106KED Bacteria BLAST swissprot:YPFH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YPFH_ECOLI BioCyc ECOL316407:JW5396-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5396-MONOMER BioCyc EcoCyc:G7296-MONOMER http://biocyc.org/getid?id=EcoCyc:G7296-MONOMER COG COG0400 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0400 DOI 10.1016/j.fmrre.2004.12.006 http://dx.doi.org/10.1016/j.fmrre.2004.12.006 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.-.- http://enzyme.expasy.org/EC/3.1.-.- EchoBASE EB3947 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3947 EcoGene EG14195 http://www.ecogene.org/geneInfo.php?eg_id=EG14195 EnsemblBacteria AAC75526 http://www.ensemblgenomes.org/id/AAC75526 EnsemblBacteria AAC75526 http://www.ensemblgenomes.org/id/AAC75526 EnsemblBacteria BAE76722 http://www.ensemblgenomes.org/id/BAE76722 EnsemblBacteria BAE76722 http://www.ensemblgenomes.org/id/BAE76722 EnsemblBacteria BAE76722 http://www.ensemblgenomes.org/id/BAE76722 EnsemblBacteria b2473 http://www.ensemblgenomes.org/id/b2473 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0008474 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008474 GO_function GO:0016788 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016788 GO_function GO:0052689 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052689 GO_process GO:0002084 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002084 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 3.40.50.1820 http://www.cathdb.info/version/latest/superfamily/3.40.50.1820 GeneID 947571 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947571 HOGENOM HOG000260141 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260141&db=HOGENOM6 InParanoid P76561 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76561 IntAct P76561 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76561* IntEnz 3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1 InterPro IPR003140 http://www.ebi.ac.uk/interpro/entry/IPR003140 InterPro IPR029058 http://www.ebi.ac.uk/interpro/entry/IPR029058 KEGG_Gene ecj:JW5396 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5396 KEGG_Gene eco:b2473 http://www.genome.jp/dbget-bin/www_bget?eco:b2473 KEGG_Orthology KO:K06999 http://www.genome.jp/dbget-bin/www_bget?KO:K06999 OMA VPKHYFD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VPKHYFD PSORT swissprot:YPFH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YPFH_ECOLI PSORT-B swissprot:YPFH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YPFH_ECOLI PSORT2 swissprot:YPFH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YPFH_ECOLI Pfam PF02230 http://pfam.xfam.org/family/PF02230 Phobius swissprot:YPFH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YPFH_ECOLI PhylomeDB P76561 http://phylomedb.org/?seqid=P76561 ProteinModelPortal P76561 http://www.proteinmodelportal.org/query/uniprot/P76561 PubMed 15808744 http://www.ncbi.nlm.nih.gov/pubmed/15808744 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416968 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416968 RefSeq WP_000679799 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000679799 SMR P76561 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76561 STRING 511145.b2473 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2473&targetmode=cogs STRING COG0400 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0400&targetmode=cogs SUPFAM SSF53474 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53474 UniProtKB YPFH_ECOLI http://www.uniprot.org/uniprot/YPFH_ECOLI UniProtKB-AC P76561 http://www.uniprot.org/uniprot/P76561 charge swissprot:YPFH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YPFH_ECOLI eggNOG COG0400 http://eggnogapi.embl.de/nog_data/html/tree/COG0400 eggNOG ENOG4106KED http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106KED epestfind swissprot:YPFH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YPFH_ECOLI garnier swissprot:YPFH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YPFH_ECOLI helixturnhelix swissprot:YPFH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YPFH_ECOLI hmoment swissprot:YPFH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YPFH_ECOLI iep swissprot:YPFH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YPFH_ECOLI inforesidue swissprot:YPFH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YPFH_ECOLI octanol swissprot:YPFH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YPFH_ECOLI pepcoil swissprot:YPFH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YPFH_ECOLI pepdigest swissprot:YPFH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YPFH_ECOLI pepinfo swissprot:YPFH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YPFH_ECOLI pepnet swissprot:YPFH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YPFH_ECOLI pepstats swissprot:YPFH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YPFH_ECOLI pepwheel swissprot:YPFH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YPFH_ECOLI pepwindow swissprot:YPFH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YPFH_ECOLI sigcleave swissprot:YPFH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YPFH_ECOLI ## Database ID URL or Descriptions # AltName PREA_ECOLI Dihydrothymine dehydrogenase # AltName PREA_ECOLI Dihydrouracil dehydrogenase # BIOPHYSICOCHEMICAL PROPERTIES PREA_ECOLI Kinetic parameters KM=38 uM for uracil (at pH 6 and 30 degrees Celsius) {ECO 0000269|PubMed 21169495}; KM=87 uM for thymidine (at pH 6 and 30 degrees Celsius) {ECO 0000269|PubMed 21169495}; KM=130 uM for DHT (at pH 11 and 30 degrees Celsius) {ECO 0000269|PubMed 21169495}; KM=160 uM for DHU (at pH 11 and 30 degrees Celsius) {ECO 0000269|PubMed 21169495}; Vmax=0.18 umol/min/mg enzyme toward DHT (at pH 11 and 30 degrees Celsius) {ECO 0000269|PubMed 21169495}; Vmax=0.26 umol/min/mg enzyme toward thymidine (at pH 6 and 30 degrees Celsius) {ECO 0000269|PubMed 21169495}; Vmax=0.43 umol/min/mg enzyme toward uracil (at pH 6 and 30 degrees Celsius) {ECO 0000269|PubMed 21169495}; Vmax=0.44 umol/min/mg enzyme toward DHU (at pH 11 and 30 degrees Celsius) {ECO 0000269|PubMed 21169495}; Vmax=0.67 umol/min/mg enzyme toward fluorouracil (at pH 6 and 30 degrees Celsius) {ECO 0000269|PubMed 21169495}; # BioGrid 4259170 9 # CATALYTIC ACTIVITY 5,6-dihydrothymine + NAD(+) = thymine + NADH. {ECO:0000269|PubMed 21169495}. # CATALYTIC ACTIVITY 5,6-dihydrouracil + NAD(+) = uracil + NADH. {ECO:0000269|PubMed 21169495}. # COFACTOR PREA_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000305}; Note=Binds 2 [4Fe-4S] clusters. {ECO 0000305}; # EcoGene EG11289 preA # FUNCTION PREA_ECOLI Involved in pyrimidine base degradation. Catalyzes physiologically the reduction of uracil to 5,6-dihydrouracil (DHU) by using NADH as a specific cosubstrate. It also catalyzes the reverse reaction and the reduction of thymine to 5,6- dihydrothymine (DHT). {ECO 0000269|PubMed 18482579, ECO 0000269|PubMed 21169495}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0003954 NADH dehydrogenase activity; IDA:UniProtKB. # GO_function GO:0004152 dihydroorotate dehydrogenase activity; IBA:GO_Central. # GO_function GO:0004159 dihydrouracil dehydrogenase (NAD+) activity; IEA:UniProtKB-EC. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051536 iron-sulfur cluster binding; IDA:EcoCyc. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process; IBA:GO_Central. # GO_process GO:0006208 pyrimidine nucleobase catabolic process; IDA:UniProtKB. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.70 -; 1. # INDUCTION Transcriptionally regulated by IscS. {ECO:0000269|PubMed 18482579}. # IntAct P25889 2 # InterPro IPR005720 Dihydroorotate_DH # InterPro IPR013785 Aldolase_TIM # InterPro IPR017896 4Fe4S_Fe-S-bd # InterPro IPR017900 4Fe4S_Fe_S_CS # Organism PREA_ECOLI Escherichia coli (strain K12) # PATRIC 32119637 VBIEscCol129921_2229 # PROSITE PS00198 4FE4S_FER_1 # PROSITE PS51379 4FE4S_FER_2; 2 # Pfam PF01180 DHO_dh # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PREA_ECOLI NAD-dependent dihydropyrimidine dehydrogenase subunit PreA # RefSeq NP_416652 NC_000913.3 # RefSeq WP_000956071 NZ_LN832404.1 # SIMILARITY Belongs to the dihydropyrimidine dehydrogenase family. {ECO 0000305}. # SIMILARITY Contains 2 4Fe-4S ferredoxin-type domains. {ECO:0000255|PROSITE-ProRule PRU00711}. # SUBUNIT Heterotetramer of 2 PreA and 2 PreT subunits. {ECO:0000269|PubMed 21169495}. # TIGRFAMs TIGR01037 pyrD_sub1_fam # eggNOG COG0167 LUCA # eggNOG COG1146 LUCA # eggNOG ENOG4107SJI Bacteria BLAST swissprot:PREA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PREA_ECOLI BioCyc ECOL316407:JW2134-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2134-MONOMER BioCyc EcoCyc:EG11289-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11289-MONOMER BioCyc MetaCyc:EG11289-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11289-MONOMER DIP DIP-11915N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11915N DOI 10.1007/BF00267469 http://dx.doi.org/10.1007/BF00267469 DOI 10.1016/j.bbrc.2008.05.019 http://dx.doi.org/10.1016/j.bbrc.2008.05.019 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01178-10 http://dx.doi.org/10.1128/JB.01178-10 EC_number EC:1.3.1.1 http://www.genome.jp/dbget-bin/www_bget?EC:1.3.1.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M59444 http://www.ebi.ac.uk/ena/data/view/M59444 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.3.1.1 http://enzyme.expasy.org/EC/1.3.1.1 EchoBASE EB1266 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1266 EcoGene EG11289 http://www.ecogene.org/geneInfo.php?eg_id=EG11289 EnsemblBacteria AAC75208 http://www.ensemblgenomes.org/id/AAC75208 EnsemblBacteria AAC75208 http://www.ensemblgenomes.org/id/AAC75208 EnsemblBacteria BAE76624 http://www.ensemblgenomes.org/id/BAE76624 EnsemblBacteria BAE76624 http://www.ensemblgenomes.org/id/BAE76624 EnsemblBacteria BAE76624 http://www.ensemblgenomes.org/id/BAE76624 EnsemblBacteria b2147 http://www.ensemblgenomes.org/id/b2147 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003954 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003954 GO_function GO:0004152 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004152 GO_function GO:0004159 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004159 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051536 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051536 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0006207 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006207 GO_process GO:0006208 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006208 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 949037 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949037 HOGENOM HOG000225106 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000225106&db=HOGENOM6 InParanoid P25889 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P25889 IntAct P25889 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P25889* IntEnz 1.3.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.3.1.1 InterPro IPR005720 http://www.ebi.ac.uk/interpro/entry/IPR005720 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR017896 http://www.ebi.ac.uk/interpro/entry/IPR017896 InterPro IPR017900 http://www.ebi.ac.uk/interpro/entry/IPR017900 KEGG_Gene ecj:JW2134 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2134 KEGG_Gene eco:b2147 http://www.genome.jp/dbget-bin/www_bget?eco:b2147 OMA MVPCVEE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MVPCVEE PROSITE PS00198 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00198 PROSITE PS51379 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51379 PSORT swissprot:PREA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PREA_ECOLI PSORT-B swissprot:PREA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PREA_ECOLI PSORT2 swissprot:PREA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PREA_ECOLI Pfam PF01180 http://pfam.xfam.org/family/PF01180 Phobius swissprot:PREA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PREA_ECOLI PhylomeDB P25889 http://phylomedb.org/?seqid=P25889 ProteinModelPortal P25889 http://www.proteinmodelportal.org/query/uniprot/P25889 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1719366 http://www.ncbi.nlm.nih.gov/pubmed/1719366 PubMed 18482579 http://www.ncbi.nlm.nih.gov/pubmed/18482579 PubMed 21169495 http://www.ncbi.nlm.nih.gov/pubmed/21169495 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416652 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416652 RefSeq WP_000956071 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000956071 SMR P25889 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P25889 STRING 511145.b2147 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2147&targetmode=cogs TIGRFAMs TIGR01037 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01037 UniProtKB PREA_ECOLI http://www.uniprot.org/uniprot/PREA_ECOLI UniProtKB-AC P25889 http://www.uniprot.org/uniprot/P25889 charge swissprot:PREA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PREA_ECOLI eggNOG COG0167 http://eggnogapi.embl.de/nog_data/html/tree/COG0167 eggNOG COG1146 http://eggnogapi.embl.de/nog_data/html/tree/COG1146 eggNOG ENOG4107SJI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107SJI epestfind swissprot:PREA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PREA_ECOLI garnier swissprot:PREA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PREA_ECOLI helixturnhelix swissprot:PREA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PREA_ECOLI hmoment swissprot:PREA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PREA_ECOLI iep swissprot:PREA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PREA_ECOLI inforesidue swissprot:PREA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PREA_ECOLI octanol swissprot:PREA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PREA_ECOLI pepcoil swissprot:PREA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PREA_ECOLI pepdigest swissprot:PREA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PREA_ECOLI pepinfo swissprot:PREA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PREA_ECOLI pepnet swissprot:PREA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PREA_ECOLI pepstats swissprot:PREA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PREA_ECOLI pepwheel swissprot:PREA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PREA_ECOLI pepwindow swissprot:PREA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PREA_ECOLI sigcleave swissprot:PREA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PREA_ECOLI ## Database ID URL or Descriptions # AltName DCUS_ECOLI Fumarate sensor # BRENDA 2.7.13 2026 # BioGrid 4261981 12 # CATALYTIC ACTIVITY DCUS_ECOLI ATP + protein L-histidine = ADP + protein N- phospho-L-histidine. # DOMAIN DCUS_ECOLI The periplasmic domain is involved in C4-dicarboxylate binding and sensing. The structural disorder in the cytoplasmic PAS domain has an important role in signal transduction to the kinase domain and may be the decisive structural feature that characterizes the activated kinase. {ECO 0000269|PubMed 12907689, ECO 0000269|PubMed 18701447, ECO 0000269|PubMed 18820688}. # ENZYME REGULATION DCUS_ECOLI Autophosphorylation is stimulated by the presence of C4-dicarboxylates such as fumarate, succinate, malate, and tartrate. # EcoGene EG12465 dcuS # FUNCTION DCUS_ECOLI Member of the two-component regulatory system DcuR/DcuS. Involved in the C4-dicarboxylate-stimulated regulation of the genes encoding the anaerobic fumarate respiratory system (frdABCD; nuoAN; dcuB; dcuC; sdhCDAB; etc.). Weakly regulates the aerobic C4-dicarboxylate transporter dctA. Activates DcuR by phosphorylation. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_component GO:0005886 plasma membrane; IDA:EcoliWiki. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; ISS:EcoliWiki. # GO_function GO:0000155 phosphorelay sensor kinase activity; IMP:EcoliWiki. # GO_function GO:0004673 protein histidine kinase activity; IDA:EcoliWiki. # GO_function GO:0004871 signal transducer activity; IDA:EcoliWiki. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0042802 identical protein binding; IPI:IntAct. # GO_process GO:0000160 phosphorelay signal transduction system; IDA:EcoliWiki. # GO_process GO:0006355 regulation of transcription, DNA-templated; IDA:EcoliWiki. # GO_process GO:0006468 protein phosphorylation; IDA:EcoliWiki. # GO_process GO:0051260 protein homooligomerization; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005622 intracellular # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # Gene3D 1.10.287.130 -; 1. # Gene3D 3.30.565.10 -; 1. # INTERACTION DCUS_ECOLI Self; NbExp=8; IntAct=EBI-1134683, EBI-1134683; # IntAct P0AEC8 3 # InterPro IPR000014 PAS # InterPro IPR003594 HATPase_C # InterPro IPR003661 HisK_dim/P # InterPro IPR004358 Sig_transdc_His_kin-like_C # InterPro IPR005467 His_kinase_dom # InterPro IPR013767 PAS_fold # InterPro IPR016120 Sig_transdc_His_kin_SpoOB # InterPro IPR029151 Sensor-like # InterPro IPR033463 sCache_3 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01001 Protein kinases # KEGG_Brite ko02022 M00488 DcuS-DcuR (aerobic C4-dicarboxylate metabolism) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # MISCELLANEOUS DCUS_ECOLI The region encompassing approximately residues 42 to 181 has been shown to be periplasmic, however exactly which residues are periplasmic is not clear. # Organism DCUS_ECOLI Escherichia coli (strain K12) # PATRIC 32123815 VBIEscCol129921_4256 # PDB 1OJG NMR; -; A=45-180 # PDB 2W0N NMR; -; A=211-325 # PDB 3BY8 X-ray; 1.45 A; A=42-181 # PIR D65222 D65222 # PRINTS PR00344 BCTRLSENSOR # PROSITE PS50109 HIS_KIN # PROSITE PS50112 PAS # PTM DCUS_ECOLI Autophosphorylated. The phosphoryl group is rapidly transferred to DcuR. # Pfam PF00989 PAS # Pfam PF02518 HATPase_c # Pfam PF17203 sCache_3_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DCUS_ECOLI Sensor histidine kinase DcuS # RefSeq NP_418549 NC_000913.3 # RefSeq WP_001216477 NZ_LN832404.1 # SIMILARITY Contains 1 PAS (PER-ARNT-SIM) domain. {ECO:0000255|PROSITE-ProRule PRU00140}. # SIMILARITY Contains 1 histidine kinase domain. {ECO:0000255|PROSITE-ProRule PRU00107}. # SMART SM00091 PAS # SMART SM00387 HATPase_c # SUBCELLULAR LOCATION DCUS_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT DCUS_ECOLI Homodimer. {ECO 0000305|PubMed 18701447, ECO 0000305|PubMed 18820688}. # SUPFAM SSF103190 SSF103190 # SUPFAM SSF55785 SSF55785 # SUPFAM SSF55874 SSF55874 # SUPFAM SSF55890 SSF55890 # eggNOG COG3290 LUCA # eggNOG ENOG4105CEQ Bacteria BLAST swissprot:DCUS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DCUS_ECOLI BioCyc ECOL316407:JW4086-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4086-MONOMER BioCyc EcoCyc:DCUS-MONOMER http://biocyc.org/getid?id=EcoCyc:DCUS-MONOMER COG COG3290 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3290 DIP DIP-9414N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9414N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsmb.1493 http://dx.doi.org/10.1038/nsmb.1493 DOI 10.1074/jbc.C300344200 http://dx.doi.org/10.1074/jbc.C300344200 DOI 10.1074/jbc.M204482200 http://dx.doi.org/10.1074/jbc.M204482200 DOI 10.1074/jbc.M805253200 http://dx.doi.org/10.1074/jbc.M805253200 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.13.3 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.13.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 2.7.13.3 http://enzyme.expasy.org/EC/2.7.13.3 EchoBASE EB2358 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2358 EcoGene EG12465 http://www.ecogene.org/geneInfo.php?eg_id=EG12465 EnsemblBacteria AAC77086 http://www.ensemblgenomes.org/id/AAC77086 EnsemblBacteria AAC77086 http://www.ensemblgenomes.org/id/AAC77086 EnsemblBacteria BAE78127 http://www.ensemblgenomes.org/id/BAE78127 EnsemblBacteria BAE78127 http://www.ensemblgenomes.org/id/BAE78127 EnsemblBacteria BAE78127 http://www.ensemblgenomes.org/id/BAE78127 EnsemblBacteria b4125 http://www.ensemblgenomes.org/id/b4125 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0000155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000155 GO_function GO:0004673 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004673 GO_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0006468 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006468 GO_process GO:0051260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.10.287.130 http://www.cathdb.info/version/latest/superfamily/1.10.287.130 Gene3D 3.30.565.10 http://www.cathdb.info/version/latest/superfamily/3.30.565.10 GeneID 948639 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948639 HOGENOM HOG000241936 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000241936&db=HOGENOM6 InParanoid P0AEC8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEC8 IntAct P0AEC8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEC8* IntEnz 2.7.13.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.13.3 InterPro IPR000014 http://www.ebi.ac.uk/interpro/entry/IPR000014 InterPro IPR003594 http://www.ebi.ac.uk/interpro/entry/IPR003594 InterPro IPR003661 http://www.ebi.ac.uk/interpro/entry/IPR003661 InterPro IPR004358 http://www.ebi.ac.uk/interpro/entry/IPR004358 InterPro IPR005467 http://www.ebi.ac.uk/interpro/entry/IPR005467 InterPro IPR013767 http://www.ebi.ac.uk/interpro/entry/IPR013767 InterPro IPR016120 http://www.ebi.ac.uk/interpro/entry/IPR016120 InterPro IPR029151 http://www.ebi.ac.uk/interpro/entry/IPR029151 InterPro IPR033463 http://www.ebi.ac.uk/interpro/entry/IPR033463 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01001 http://www.genome.jp/dbget-bin/www_bget?ko01001 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW4086 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4086 KEGG_Gene eco:b4125 http://www.genome.jp/dbget-bin/www_bget?eco:b4125 KEGG_Orthology KO:K07701 http://www.genome.jp/dbget-bin/www_bget?KO:K07701 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA HYQNGWL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HYQNGWL PDB 1OJG http://www.ebi.ac.uk/pdbe-srv/view/entry/1OJG PDB 2W0N http://www.ebi.ac.uk/pdbe-srv/view/entry/2W0N PDB 3BY8 http://www.ebi.ac.uk/pdbe-srv/view/entry/3BY8 PDBsum 1OJG http://www.ebi.ac.uk/pdbsum/1OJG PDBsum 2W0N http://www.ebi.ac.uk/pdbsum/2W0N PDBsum 3BY8 http://www.ebi.ac.uk/pdbsum/3BY8 PRINTS PR00344 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00344 PROSITE PS50109 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50109 PROSITE PS50112 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50112 PSORT swissprot:DCUS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DCUS_ECOLI PSORT-B swissprot:DCUS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DCUS_ECOLI PSORT2 swissprot:DCUS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DCUS_ECOLI Pfam PF00989 http://pfam.xfam.org/family/PF00989 Pfam PF02518 http://pfam.xfam.org/family/PF02518 Pfam PF17203 http://pfam.xfam.org/family/PF17203 Phobius swissprot:DCUS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DCUS_ECOLI PhylomeDB P0AEC8 http://phylomedb.org/?seqid=P0AEC8 ProteinModelPortal P0AEC8 http://www.proteinmodelportal.org/query/uniprot/P0AEC8 PubMed 12167640 http://www.ncbi.nlm.nih.gov/pubmed/12167640 PubMed 12907689 http://www.ncbi.nlm.nih.gov/pubmed/12907689 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18701447 http://www.ncbi.nlm.nih.gov/pubmed/18701447 PubMed 18820688 http://www.ncbi.nlm.nih.gov/pubmed/18820688 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9765574 http://www.ncbi.nlm.nih.gov/pubmed/9765574 PubMed 9973351 http://www.ncbi.nlm.nih.gov/pubmed/9973351 RefSeq NP_418549 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418549 RefSeq WP_001216477 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001216477 SMART SM00091 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00091 SMART SM00387 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00387 SMR P0AEC8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEC8 STRING 511145.b4125 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4125&targetmode=cogs STRING COG3290 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3290&targetmode=cogs SUPFAM SSF103190 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103190 SUPFAM SSF55785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55785 SUPFAM SSF55874 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55874 SUPFAM SSF55890 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55890 UniProtKB DCUS_ECOLI http://www.uniprot.org/uniprot/DCUS_ECOLI UniProtKB-AC P0AEC8 http://www.uniprot.org/uniprot/P0AEC8 charge swissprot:DCUS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DCUS_ECOLI eggNOG COG3290 http://eggnogapi.embl.de/nog_data/html/tree/COG3290 eggNOG ENOG4105CEQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CEQ epestfind swissprot:DCUS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DCUS_ECOLI garnier swissprot:DCUS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DCUS_ECOLI helixturnhelix swissprot:DCUS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DCUS_ECOLI hmoment swissprot:DCUS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DCUS_ECOLI iep swissprot:DCUS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DCUS_ECOLI inforesidue swissprot:DCUS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DCUS_ECOLI octanol swissprot:DCUS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DCUS_ECOLI pepcoil swissprot:DCUS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DCUS_ECOLI pepdigest swissprot:DCUS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DCUS_ECOLI pepinfo swissprot:DCUS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DCUS_ECOLI pepnet swissprot:DCUS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DCUS_ECOLI pepstats swissprot:DCUS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DCUS_ECOLI pepwheel swissprot:DCUS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DCUS_ECOLI pepwindow swissprot:DCUS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DCUS_ECOLI sigcleave swissprot:DCUS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DCUS_ECOLI ## Database ID URL or Descriptions # BioGrid 4260366 5 # ENZYME REGULATION The FliY-YecC-YecS system is inhibited by L- cystine, L-cysteine, DL-2,6-diaminopimelic acid and L- cystathionine, and is stimulated by D-cysteine. {ECO:0000269|PubMed 25139244}. # EcoGene EG12347 yecC # FUNCTION YECC_ECOLI Part of the ABC transporter complex FliY-YecC-YecS involved in L-cystine transport. The system can probably also transport L-cysteine, and it mediates accumulation of the toxic compounds L-selenaproline (SCA) and L-selenocystine (SeCys) (PubMed 25139244). Probably responsible for energy coupling to the transport system (Probable). {ECO 0000269|PubMed 25139244, ECO 0000305}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0015184 L-cystine transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0015424 amino acid-transporting ATPase activity; IEA:InterPro. # GO_function GO:0033229 cysteine transmembrane transporter activity; IDA:EcoCyc. # GO_process GO:0015811 L-cystine transport; IDA:EcoCyc. # GO_process GO:0042883 cysteine transport; IDA:EcoCyc. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # Gene3D 3.40.50.300 -; 1. # IntAct P37774 5 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # InterPro IPR030679 ABC_ATPase_HisP-typ # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00234 Cystine transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism YECC_ECOLI Escherichia coli (strain K12) # PATRIC 32119169 VBIEscCol129921_1999 # PIR B64955 B64955 # PIRSF PIRSF039085 ABC_ATPase_HisP # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # Pfam PF00005 ABC_tran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName L-cystine transport system ATP-binding protein YecC {ECO 0000305} # RefSeq NP_416427 NC_000913.3 # RefSeq WP_001272991 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA # SUBCELLULAR LOCATION YECC_ECOLI Cell inner membrane {ECO 0000305}; Peripheral membrane protein {ECO 0000305}. # SUBUNIT The complex is composed of two ATP-binding proteins (YecC), two transmembrane proteins (YecS) and a solute-binding protein (FliY). {ECO 0000305}. # SUPFAM SSF52540 SSF52540 # TCDB 3.A.1.3.10 the atp-binding cassette (abc) superfamily # eggNOG COG1126 LUCA # eggNOG ENOG4105CDA Bacteria BLAST swissprot:YECC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YECC_ECOLI BioCyc ECOL316407:JW1902-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1902-MONOMER BioCyc EcoCyc:EG12347-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12347-MONOMER BioCyc MetaCyc:EG12347-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12347-MONOMER COG COG1126 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1126 DIP DIP-11822N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11822N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/nar/14.5.2301 http://dx.doi.org/10.1093/nar/14.5.2301 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1111/jam.12623 http://dx.doi.org/10.1111/jam.12623 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.3.- {ECO:0000305} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.- {ECO:0000305} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X03691 http://www.ebi.ac.uk/ena/data/view/X03691 ENZYME 3.6.3.- {ECO:0000305} http://enzyme.expasy.org/EC/3.6.3.- {ECO:0000305} EchoBASE EB2251 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2251 EcoGene EG12347 http://www.ecogene.org/geneInfo.php?eg_id=EG12347 EnsemblBacteria AAC74984 http://www.ensemblgenomes.org/id/AAC74984 EnsemblBacteria AAC74984 http://www.ensemblgenomes.org/id/AAC74984 EnsemblBacteria BAA15737 http://www.ensemblgenomes.org/id/BAA15737 EnsemblBacteria BAA15737 http://www.ensemblgenomes.org/id/BAA15737 EnsemblBacteria BAA15737 http://www.ensemblgenomes.org/id/BAA15737 EnsemblBacteria b1917 http://www.ensemblgenomes.org/id/b1917 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0015184 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015184 GO_function GO:0015424 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015424 GO_function GO:0033229 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033229 GO_process GO:0015811 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015811 GO_process GO:0042883 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042883 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 946422 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946422 InParanoid P37774 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37774 IntAct P37774 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37774* IntEnz 3.6.3.- {ECO:0000305} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.- {ECO:0000305} InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR030679 http://www.ebi.ac.uk/interpro/entry/IPR030679 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1902 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1902 KEGG_Gene eco:b1917 http://www.genome.jp/dbget-bin/www_bget?eco:b1917 KEGG_Orthology KO:K10010 http://www.genome.jp/dbget-bin/www_bget?KO:K10010 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 MINT MINT-1262709 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1262709 OMA EVIFMDQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EVIFMDQ PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:YECC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YECC_ECOLI PSORT-B swissprot:YECC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YECC_ECOLI PSORT2 swissprot:YECC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YECC_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Phobius swissprot:YECC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YECC_ECOLI PhylomeDB P37774 http://phylomedb.org/?seqid=P37774 ProteinModelPortal P37774 http://www.proteinmodelportal.org/query/uniprot/P37774 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 25139244 http://www.ncbi.nlm.nih.gov/pubmed/25139244 PubMed 3515318 http://www.ncbi.nlm.nih.gov/pubmed/3515318 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416427 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416427 RefSeq WP_001272991 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001272991 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P37774 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37774 STRING 511145.b1917 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1917&targetmode=cogs STRING COG1126 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1126&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.3.10 http://www.tcdb.org/search/result.php?tc=3.A.1.3.10 UniProtKB YECC_ECOLI http://www.uniprot.org/uniprot/YECC_ECOLI UniProtKB-AC P37774 http://www.uniprot.org/uniprot/P37774 charge swissprot:YECC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YECC_ECOLI eggNOG COG1126 http://eggnogapi.embl.de/nog_data/html/tree/COG1126 eggNOG ENOG4105CDA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CDA epestfind swissprot:YECC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YECC_ECOLI garnier swissprot:YECC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YECC_ECOLI helixturnhelix swissprot:YECC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YECC_ECOLI hmoment swissprot:YECC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YECC_ECOLI iep swissprot:YECC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YECC_ECOLI inforesidue swissprot:YECC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YECC_ECOLI octanol swissprot:YECC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YECC_ECOLI pepcoil swissprot:YECC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YECC_ECOLI pepdigest swissprot:YECC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YECC_ECOLI pepinfo swissprot:YECC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YECC_ECOLI pepnet swissprot:YECC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YECC_ECOLI pepstats swissprot:YECC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YECC_ECOLI pepwheel swissprot:YECC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YECC_ECOLI pepwindow swissprot:YECC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YECC_ECOLI sigcleave swissprot:YECC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YECC_ECOLI ## Database ID URL or Descriptions # AltName GLPG_ECOLI Intramembrane serine protease # BRENDA 3.4.21.105 2026 # BioGrid 4262105 13 # CATALYTIC ACTIVITY GLPG_ECOLI Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains. # CAUTION Was originally identified as a repressor of the glycerol- 3-phosphate regulon. {ECO:0000305|PubMed 8955387}. # DOMAIN GLPG_ECOLI The loop between transmembrane domains 5 and 6 is flexible and may readily open to the extracellular side to allow water entry into the active site cavity. {ECO 0000269|PubMed 17099694}. # EcoGene EG10397 glpG # FUNCTION GLPG_ECOLI Rhomboid-type serine protease that catalyzes intramembrane proteolysis. {ECO 0000269|PubMed 16216077, ECO 0000269|PubMed 17099694}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_function GO:0004175 endopeptidase activity; IDA:EcoCyc. # GO_function GO:0004252 serine-type endopeptidase activity; IMP:EcoCyc. # GO_process GO:0006508 proteolysis; IDA:EcoCyc. # GO_process GO:0016485 protein processing; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0008233 peptidase activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0051604 protein maturation # Gene3D 1.20.1540.10 -; 1. # HAMAP MF_01594 Rhomboid_GlpG # IntAct P09391 2 # InterPro IPR002610 Peptidase_S54_rhomboid # InterPro IPR022732 Peptidase_S54_GlpG_N # InterPro IPR022764 Peptidase_S54_rhomboid_dom # InterPro IPR023662 Rhomboid_protease_GlpG # Organism GLPG_ECOLI Escherichia coli (strain K12) # PANTHER PTHR22936 PTHR22936 # PATRIC 32122284 VBIEscCol129921_3519 # PDB 2IC8 X-ray; 2.10 A; A=91-272 # PDB 2IRV X-ray; 2.30 A; A/B=92-273 # PDB 2LEP NMR; -; A=1-61 # PDB 2NRF X-ray; 2.60 A; A/B=91-272 # PDB 2O7L X-ray; 2.50 A; A=93-272 # PDB 2XOV X-ray; 1.65 A; A=91-271 # PDB 2XOW X-ray; 2.09 A; A=92-270 # PDB 2XTU X-ray; 1.85 A; A=91-271 # PDB 2XTV X-ray; 1.70 A; A=93-272 # PDB 3B44 X-ray; 1.70 A; A=91-270 # PDB 3B45 X-ray; 1.90 A; A=91-270 # PDB 3TXT X-ray; 2.30 A; A=92-270 # PDB 3UBB X-ray; 2.60 A; A=91-272 # PDB 3ZEB X-ray; 2.20 A; A=92-270 # PDB 3ZMH X-ray; 2.30 A; A=91-270 # PDB 3ZMI X-ray; 2.20 A; A=92-270 # PDB 3ZMJ X-ray; 2.30 A; A=92-270 # PDB 3ZOT X-ray; 2.40 A; A=92-271 # PDB 4H1D X-ray; 2.90 A; A=92-270 # PDB 4HDD X-ray; 1.35 A; A=2-74 # PDB 4NJN X-ray; 2.40 A; A=87-276 # PDB 4NJP X-ray; 2.40 A; A=87-276 # PDB 5F5B X-ray; 2.30 A; A=87-276 # PDB 5F5D X-ray; 2.50 A; A=87-276 # PDB 5F5G X-ray; 2.30 A; A=87-276 # PDB 5F5J X-ray; 2.40 A; A=87-276 # PDB 5F5K X-ray; 2.40 A; A=87-276 # PIR C65138 BVECGG # Pfam PF01694 Rhomboid # Pfam PF12122 Rhomboid_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLPG_ECOLI Rhomboid protease GlpG # RefSeq WP_000928723 NZ_LN832404.1 # RefSeq YP_026220 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA58222.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the peptidase S54 family. {ECO 0000305}. # SUBCELLULAR LOCATION GLPG_ECOLI Cell inner membrane {ECO 0000269|PubMed 16216077}; Multi-pass membrane protein {ECO 0000269|PubMed 16216077}. # TCDB 9.B.104.1 the rhomboid protease (rhomboid) family # TIGRFAMs TIGR04239 rhombo_GlpG # eggNOG COG0705 LUCA # eggNOG ENOG4105EBW Bacteria BLAST swissprot:GLPG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLPG_ECOLI BioCyc ECOL316407:JW5687-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5687-MONOMER BioCyc EcoCyc:EG10397-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10397-MONOMER BioCyc MetaCyc:EG10397-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10397-MONOMER COG COG0705 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0705 DIP DIP-9796N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9796N DOI 10.1021/bi051363k http://dx.doi.org/10.1021/bi051363k DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature05255 http://dx.doi.org/10.1038/nature05255 DOI 10.1038/nsmb1179 http://dx.doi.org/10.1038/nsmb1179 DOI 10.1073/pnas.0609773104 http://dx.doi.org/10.1073/pnas.0609773104 DOI 10.1073/pnas.0611080104 http://dx.doi.org/10.1073/pnas.0611080104 DOI 10.1093/nar/16.15.7732 http://dx.doi.org/10.1093/nar/16.15.7732 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1111/j.1365-2958.2007.05679.x http://dx.doi.org/10.1111/j.1365-2958.2007.05679.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.188.9.3415-3419.2006 http://dx.doi.org/10.1128/JB.188.9.3415-3419.2006 EC_number EC:3.4.21.105 http://www.genome.jp/dbget-bin/www_bget?EC:3.4.21.105 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M54940 http://www.ebi.ac.uk/ena/data/view/M54940 EMBL M96795 http://www.ebi.ac.uk/ena/data/view/M96795 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X07520 http://www.ebi.ac.uk/ena/data/view/X07520 ENZYME 3.4.21.105 http://enzyme.expasy.org/EC/3.4.21.105 EchoBASE EB0392 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0392 EcoGene EG10397 http://www.ecogene.org/geneInfo.php?eg_id=EG10397 EnsemblBacteria AAT48182 http://www.ensemblgenomes.org/id/AAT48182 EnsemblBacteria AAT48182 http://www.ensemblgenomes.org/id/AAT48182 EnsemblBacteria BAE77868 http://www.ensemblgenomes.org/id/BAE77868 EnsemblBacteria BAE77868 http://www.ensemblgenomes.org/id/BAE77868 EnsemblBacteria BAE77868 http://www.ensemblgenomes.org/id/BAE77868 EnsemblBacteria b3424 http://www.ensemblgenomes.org/id/b3424 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0004175 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004175 GO_function GO:0004252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004252 GO_process GO:0006508 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006508 GO_process GO:0016485 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016485 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 Gene3D 1.20.1540.10 http://www.cathdb.info/version/latest/superfamily/1.20.1540.10 GeneID 947936 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947936 HAMAP MF_01594 http://hamap.expasy.org/unirule/MF_01594 HOGENOM HOG000269640 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000269640&db=HOGENOM6 InParanoid P09391 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P09391 IntAct P09391 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P09391* IntEnz 3.4.21.105 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.21.105 InterPro IPR002610 http://www.ebi.ac.uk/interpro/entry/IPR002610 InterPro IPR022732 http://www.ebi.ac.uk/interpro/entry/IPR022732 InterPro IPR022764 http://www.ebi.ac.uk/interpro/entry/IPR022764 InterPro IPR023662 http://www.ebi.ac.uk/interpro/entry/IPR023662 KEGG_Gene ecj:JW5687 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5687 KEGG_Gene eco:b3424 http://www.genome.jp/dbget-bin/www_bget?eco:b3424 KEGG_Orthology KO:K02441 http://www.genome.jp/dbget-bin/www_bget?KO:K02441 OMA HFSAMHI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HFSAMHI PANTHER PTHR22936 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22936 PDB 2IC8 http://www.ebi.ac.uk/pdbe-srv/view/entry/2IC8 PDB 2IRV http://www.ebi.ac.uk/pdbe-srv/view/entry/2IRV PDB 2LEP http://www.ebi.ac.uk/pdbe-srv/view/entry/2LEP PDB 2NRF http://www.ebi.ac.uk/pdbe-srv/view/entry/2NRF PDB 2O7L http://www.ebi.ac.uk/pdbe-srv/view/entry/2O7L PDB 2XOV http://www.ebi.ac.uk/pdbe-srv/view/entry/2XOV PDB 2XOW http://www.ebi.ac.uk/pdbe-srv/view/entry/2XOW PDB 2XTU http://www.ebi.ac.uk/pdbe-srv/view/entry/2XTU PDB 2XTV http://www.ebi.ac.uk/pdbe-srv/view/entry/2XTV PDB 3B44 http://www.ebi.ac.uk/pdbe-srv/view/entry/3B44 PDB 3B45 http://www.ebi.ac.uk/pdbe-srv/view/entry/3B45 PDB 3TXT http://www.ebi.ac.uk/pdbe-srv/view/entry/3TXT PDB 3UBB http://www.ebi.ac.uk/pdbe-srv/view/entry/3UBB PDB 3ZEB http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZEB PDB 3ZMH http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZMH PDB 3ZMI http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZMI PDB 3ZMJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZMJ PDB 3ZOT http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZOT PDB 4H1D http://www.ebi.ac.uk/pdbe-srv/view/entry/4H1D PDB 4HDD http://www.ebi.ac.uk/pdbe-srv/view/entry/4HDD PDB 4NJN http://www.ebi.ac.uk/pdbe-srv/view/entry/4NJN PDB 4NJP http://www.ebi.ac.uk/pdbe-srv/view/entry/4NJP PDB 5F5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5F5B PDB 5F5D http://www.ebi.ac.uk/pdbe-srv/view/entry/5F5D PDB 5F5G http://www.ebi.ac.uk/pdbe-srv/view/entry/5F5G PDB 5F5J http://www.ebi.ac.uk/pdbe-srv/view/entry/5F5J PDB 5F5K http://www.ebi.ac.uk/pdbe-srv/view/entry/5F5K PDBsum 2IC8 http://www.ebi.ac.uk/pdbsum/2IC8 PDBsum 2IRV http://www.ebi.ac.uk/pdbsum/2IRV PDBsum 2LEP http://www.ebi.ac.uk/pdbsum/2LEP PDBsum 2NRF http://www.ebi.ac.uk/pdbsum/2NRF PDBsum 2O7L http://www.ebi.ac.uk/pdbsum/2O7L PDBsum 2XOV http://www.ebi.ac.uk/pdbsum/2XOV PDBsum 2XOW http://www.ebi.ac.uk/pdbsum/2XOW PDBsum 2XTU http://www.ebi.ac.uk/pdbsum/2XTU PDBsum 2XTV http://www.ebi.ac.uk/pdbsum/2XTV PDBsum 3B44 http://www.ebi.ac.uk/pdbsum/3B44 PDBsum 3B45 http://www.ebi.ac.uk/pdbsum/3B45 PDBsum 3TXT http://www.ebi.ac.uk/pdbsum/3TXT PDBsum 3UBB http://www.ebi.ac.uk/pdbsum/3UBB PDBsum 3ZEB http://www.ebi.ac.uk/pdbsum/3ZEB PDBsum 3ZMH http://www.ebi.ac.uk/pdbsum/3ZMH PDBsum 3ZMI http://www.ebi.ac.uk/pdbsum/3ZMI PDBsum 3ZMJ http://www.ebi.ac.uk/pdbsum/3ZMJ PDBsum 3ZOT http://www.ebi.ac.uk/pdbsum/3ZOT PDBsum 4H1D http://www.ebi.ac.uk/pdbsum/4H1D PDBsum 4HDD http://www.ebi.ac.uk/pdbsum/4HDD PDBsum 4NJN http://www.ebi.ac.uk/pdbsum/4NJN PDBsum 4NJP http://www.ebi.ac.uk/pdbsum/4NJP PDBsum 5F5B http://www.ebi.ac.uk/pdbsum/5F5B PDBsum 5F5D http://www.ebi.ac.uk/pdbsum/5F5D PDBsum 5F5G http://www.ebi.ac.uk/pdbsum/5F5G PDBsum 5F5J http://www.ebi.ac.uk/pdbsum/5F5J PDBsum 5F5K http://www.ebi.ac.uk/pdbsum/5F5K PSORT swissprot:GLPG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLPG_ECOLI PSORT-B swissprot:GLPG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLPG_ECOLI PSORT2 swissprot:GLPG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLPG_ECOLI Pfam PF01694 http://pfam.xfam.org/family/PF01694 Pfam PF12122 http://pfam.xfam.org/family/PF12122 Phobius swissprot:GLPG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLPG_ECOLI PhylomeDB P09391 http://phylomedb.org/?seqid=P09391 ProteinModelPortal P09391 http://www.proteinmodelportal.org/query/uniprot/P09391 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16216077 http://www.ncbi.nlm.nih.gov/pubmed/16216077 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16621838 http://www.ncbi.nlm.nih.gov/pubmed/16621838 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17051161 http://www.ncbi.nlm.nih.gov/pubmed/17051161 PubMed 17099694 http://www.ncbi.nlm.nih.gov/pubmed/17099694 PubMed 17190827 http://www.ncbi.nlm.nih.gov/pubmed/17190827 PubMed 17277078 http://www.ncbi.nlm.nih.gov/pubmed/17277078 PubMed 17493126 http://www.ncbi.nlm.nih.gov/pubmed/17493126 PubMed 3045764 http://www.ncbi.nlm.nih.gov/pubmed/3045764 PubMed 8955387 http://www.ncbi.nlm.nih.gov/pubmed/8955387 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000928723 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000928723 RefSeq YP_026220 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026220 SMR P09391 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P09391 STRING 511145.b3424 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3424&targetmode=cogs STRING COG0705 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0705&targetmode=cogs TCDB 9.B.104.1 http://www.tcdb.org/search/result.php?tc=9.B.104.1 TIGRFAMs TIGR04239 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR04239 UniProtKB GLPG_ECOLI http://www.uniprot.org/uniprot/GLPG_ECOLI UniProtKB-AC P09391 http://www.uniprot.org/uniprot/P09391 charge swissprot:GLPG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLPG_ECOLI eggNOG COG0705 http://eggnogapi.embl.de/nog_data/html/tree/COG0705 eggNOG ENOG4105EBW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EBW epestfind swissprot:GLPG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLPG_ECOLI garnier swissprot:GLPG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLPG_ECOLI helixturnhelix swissprot:GLPG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLPG_ECOLI hmoment swissprot:GLPG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLPG_ECOLI iep swissprot:GLPG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLPG_ECOLI inforesidue swissprot:GLPG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLPG_ECOLI octanol swissprot:GLPG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLPG_ECOLI pepcoil swissprot:GLPG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLPG_ECOLI pepdigest swissprot:GLPG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLPG_ECOLI pepinfo swissprot:GLPG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLPG_ECOLI pepnet swissprot:GLPG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLPG_ECOLI pepstats swissprot:GLPG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLPG_ECOLI pepwheel swissprot:GLPG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLPG_ECOLI pepwindow swissprot:GLPG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLPG_ECOLI sigcleave swissprot:GLPG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLPG_ECOLI ## Database ID URL or Descriptions # BioGrid 4262018 126 # EcoGene EG10958 soxS # FUNCTION SOXS_ECOLI Transcriptional activator of the superoxide response regulon of E.coli that includes at least 10 genes such as sodA, nfo, zwf and micF. Binds the DNA sequence 5'-GCACN(7)CAA-3'. It also facilitates the subsequent binding of RNA polymerase to the micF and the nfo promoters. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0000986 bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding; IDA:EcoCyc. # GO_function GO:0001108 bacterial-type RNA polymerase holo enzyme binding; IDA:EcoCyc. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IBA:GO_Central. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.60 -; 2. # INDUCTION SOXS_ECOLI By paraquat. # IntAct P0A9E2 10 # InterPro IPR009057 Homeodomain-like # InterPro IPR018060 HTH_AraC # InterPro IPR018062 HTH_AraC-typ_CS # InterPro IPR020449 Tscrpt_reg_HTH_AraC-type # KEGG_Brite ko03000 Transcription factors # Organism SOXS_ECOLI Escherichia coli (strain K12) # PATRIC 32123669 VBIEscCol129921_4183 # PIR JS0578 JS0578 # PRINTS PR00032 HTHARAC # PROSITE PS00041 HTH_ARAC_FAMILY_1 # PROSITE PS01124 HTH_ARAC_FAMILY_2 # Pfam PF12833 HTH_18 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SOXS_ECOLI Regulatory protein SoxS # RefSeq NP_418486 NC_000913.3 # RefSeq WP_000019358 NZ_LN832404.1 # SIMILARITY Contains 1 HTH araC/xylS-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00593}. # SMART SM00342 HTH_ARAC # SUBCELLULAR LOCATION SOXS_ECOLI Cytoplasm. # SUPFAM SSF46689 SSF46689; 2 # eggNOG ENOG4108W3Q Bacteria # eggNOG ENOG4111IXA LUCA BLAST swissprot:SOXS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SOXS_ECOLI BioCyc ECOL316407:JW4023-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4023-MONOMER BioCyc EcoCyc:PD00406 http://biocyc.org/getid?id=EcoCyc:PD00406 COG COG2207 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2207 DIP DIP-10904N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10904N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/19.16.4479 http://dx.doi.org/10.1093/nar/19.16.4479 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M60111 http://www.ebi.ac.uk/ena/data/view/M60111 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X59593 http://www.ebi.ac.uk/ena/data/view/X59593 EchoBASE EB0951 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0951 EcoGene EG10958 http://www.ecogene.org/geneInfo.php?eg_id=EG10958 EnsemblBacteria AAC77032 http://www.ensemblgenomes.org/id/AAC77032 EnsemblBacteria AAC77032 http://www.ensemblgenomes.org/id/AAC77032 EnsemblBacteria BAE78064 http://www.ensemblgenomes.org/id/BAE78064 EnsemblBacteria BAE78064 http://www.ensemblgenomes.org/id/BAE78064 EnsemblBacteria BAE78064 http://www.ensemblgenomes.org/id/BAE78064 EnsemblBacteria b4062 http://www.ensemblgenomes.org/id/b4062 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000986 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000986 GO_function GO:0001108 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001108 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 GeneID 948567 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948567 HOGENOM HOG000120762 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120762&db=HOGENOM6 InParanoid P0A9E2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9E2 IntAct P0A9E2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9E2* InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR018060 http://www.ebi.ac.uk/interpro/entry/IPR018060 InterPro IPR018062 http://www.ebi.ac.uk/interpro/entry/IPR018062 InterPro IPR020449 http://www.ebi.ac.uk/interpro/entry/IPR020449 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW4023 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4023 KEGG_Gene eco:b4062 http://www.genome.jp/dbget-bin/www_bget?eco:b4062 KEGG_Orthology KO:K13631 http://www.genome.jp/dbget-bin/www_bget?KO:K13631 OMA LTHWIDQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LTHWIDQ PRINTS PR00032 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00032 PROSITE PS00041 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00041 PROSITE PS01124 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01124 PSORT swissprot:SOXS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SOXS_ECOLI PSORT-B swissprot:SOXS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SOXS_ECOLI PSORT2 swissprot:SOXS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SOXS_ECOLI Pfam PF12833 http://pfam.xfam.org/family/PF12833 Phobius swissprot:SOXS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SOXS_ECOLI PhylomeDB P0A9E2 http://phylomedb.org/?seqid=P0A9E2 ProteinModelPortal P0A9E2 http://www.proteinmodelportal.org/query/uniprot/P0A9E2 PubMed 1653416 http://www.ncbi.nlm.nih.gov/pubmed/1653416 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1708380 http://www.ncbi.nlm.nih.gov/pubmed/1708380 PubMed 8034583 http://www.ncbi.nlm.nih.gov/pubmed/8034583 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418486 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418486 RefSeq WP_000019358 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000019358 SMART SM00342 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00342 SMR P0A9E2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9E2 STRING 511145.b4062 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4062&targetmode=cogs STRING COG2207 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2207&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 UniProtKB SOXS_ECOLI http://www.uniprot.org/uniprot/SOXS_ECOLI UniProtKB-AC P0A9E2 http://www.uniprot.org/uniprot/P0A9E2 charge swissprot:SOXS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SOXS_ECOLI eggNOG ENOG4108W3Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108W3Q eggNOG ENOG4111IXA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111IXA epestfind swissprot:SOXS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SOXS_ECOLI garnier swissprot:SOXS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SOXS_ECOLI helixturnhelix swissprot:SOXS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SOXS_ECOLI hmoment swissprot:SOXS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SOXS_ECOLI iep swissprot:SOXS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SOXS_ECOLI inforesidue swissprot:SOXS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SOXS_ECOLI octanol swissprot:SOXS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SOXS_ECOLI pepcoil swissprot:SOXS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SOXS_ECOLI pepdigest swissprot:SOXS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SOXS_ECOLI pepinfo swissprot:SOXS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SOXS_ECOLI pepnet swissprot:SOXS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SOXS_ECOLI pepstats swissprot:SOXS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SOXS_ECOLI pepwheel swissprot:SOXS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SOXS_ECOLI pepwindow swissprot:SOXS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SOXS_ECOLI sigcleave swissprot:SOXS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SOXS_ECOLI ## Database ID URL or Descriptions # BioGrid 4260473 90 # EcoGene EG10155 cirA # FUNCTION CIRA_ECOLI Not yet known. Postulated to participate in iron transport. Outer membrane receptor for colicins IA and IB. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0004872 receptor activity; IEA:InterPro. # GO_function GO:0015343 siderophore transmembrane transporter activity; IMP:EcoCyc. # GO_function GO:0042912 colicin transmembrane transporter activity; IDA:EcoCyc. # GO_process GO:0033212 iron assimilation; IEP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008565 protein transporter activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0042592 homeostatic process # Gene3D 2.170.130.10 -; 1. # Gene3D 2.40.170.20 -; 1. # INDUCTION CIRA_ECOLI By iron and by a cAMP/cAMP receptor protein complex. # IntAct P17315 7 # InterPro IPR000531 TonB-dep_rcpt_b-brl # InterPro IPR010916 TonB_box_CS # InterPro IPR010917 TonB_rcpt_CS # InterPro IPR012910 Plug_dom # KEGG_Brite ko02000 Transporters # Organism CIRA_ECOLI Escherichia coli (strain K12) # PATRIC 32119657 VBIEscCol129921_2239 # PDB 2HDF X-ray; 2.65 A; A=26-663 # PDB 2HDI X-ray; 2.50 A; A=26-663 # PIR B64984 QRECIC # PROSITE PS00430 TONB_DEPENDENT_REC_1 # PROSITE PS01156 TONB_DEPENDENT_REC_2 # Pfam PF00593 TonB_dep_Rec # Pfam PF07715 Plug # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CIRA_ECOLI Colicin I receptor # RefSeq NP_416660 NC_000913.3 # RefSeq WP_000489247 NZ_LN832404.1 # SIMILARITY Belongs to the TonB-dependent receptor family. {ECO 0000305}. # SUBCELLULAR LOCATION CIRA_ECOLI Cell outer membrane. # TCDB 1.B.14.1 the outer membrane receptor (omr) family # eggNOG COG4771 LUCA # eggNOG ENOG4105D05 Bacteria BLAST swissprot:CIRA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CIRA_ECOLI BioCyc ECOL316407:JW2142-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2142-MONOMER BioCyc EcoCyc:EG10155-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10155-MONOMER BioCyc MetaCyc:EG10155-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10155-MONOMER COG COG4771 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4771 DIP DIP-9282N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9282N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J04229 http://www.ebi.ac.uk/ena/data/view/J04229 EMBL M19295 http://www.ebi.ac.uk/ena/data/view/M19295 EMBL M89774 http://www.ebi.ac.uk/ena/data/view/M89774 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0153 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0153 EcoGene EG10155 http://www.ecogene.org/geneInfo.php?eg_id=EG10155 EnsemblBacteria AAC75216 http://www.ensemblgenomes.org/id/AAC75216 EnsemblBacteria AAC75216 http://www.ensemblgenomes.org/id/AAC75216 EnsemblBacteria BAE76632 http://www.ensemblgenomes.org/id/BAE76632 EnsemblBacteria BAE76632 http://www.ensemblgenomes.org/id/BAE76632 EnsemblBacteria BAE76632 http://www.ensemblgenomes.org/id/BAE76632 EnsemblBacteria b2155 http://www.ensemblgenomes.org/id/b2155 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0004872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004872 GO_function GO:0015343 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015343 GO_function GO:0042912 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042912 GO_process GO:0033212 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033212 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 Gene3D 2.170.130.10 http://www.cathdb.info/version/latest/superfamily/2.170.130.10 Gene3D 2.40.170.20 http://www.cathdb.info/version/latest/superfamily/2.40.170.20 GeneID 949042 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949042 HOGENOM HOG000276828 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276828&db=HOGENOM6 InParanoid P17315 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P17315 IntAct P17315 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P17315* InterPro IPR000531 http://www.ebi.ac.uk/interpro/entry/IPR000531 InterPro IPR010916 http://www.ebi.ac.uk/interpro/entry/IPR010916 InterPro IPR010917 http://www.ebi.ac.uk/interpro/entry/IPR010917 InterPro IPR012910 http://www.ebi.ac.uk/interpro/entry/IPR012910 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2142 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2142 KEGG_Gene eco:b2155 http://www.genome.jp/dbget-bin/www_bget?eco:b2155 KEGG_Orthology KO:K16089 http://www.genome.jp/dbget-bin/www_bget?KO:K16089 MINT MINT-4794244 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-4794244 OMA FQNNVDD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FQNNVDD PDB 2HDF http://www.ebi.ac.uk/pdbe-srv/view/entry/2HDF PDB 2HDI http://www.ebi.ac.uk/pdbe-srv/view/entry/2HDI PDBsum 2HDF http://www.ebi.ac.uk/pdbsum/2HDF PDBsum 2HDI http://www.ebi.ac.uk/pdbsum/2HDI PROSITE PS00430 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00430 PROSITE PS01156 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01156 PSORT swissprot:CIRA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CIRA_ECOLI PSORT-B swissprot:CIRA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CIRA_ECOLI PSORT2 swissprot:CIRA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CIRA_ECOLI Pfam PF00593 http://pfam.xfam.org/family/PF00593 Pfam PF07715 http://pfam.xfam.org/family/PF07715 Phobius swissprot:CIRA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CIRA_ECOLI PhylomeDB P17315 http://phylomedb.org/?seqid=P17315 ProteinModelPortal P17315 http://www.proteinmodelportal.org/query/uniprot/P17315 PubMed 1315732 http://www.ncbi.nlm.nih.gov/pubmed/1315732 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2160948 http://www.ncbi.nlm.nih.gov/pubmed/2160948 PubMed 2644220 http://www.ncbi.nlm.nih.gov/pubmed/2644220 PubMed 3316180 http://www.ncbi.nlm.nih.gov/pubmed/3316180 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_416660 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416660 RefSeq WP_000489247 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000489247 SMR P17315 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P17315 STRING 511145.b2155 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2155&targetmode=cogs STRING COG4771 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4771&targetmode=cogs SWISS-2DPAGE P17315 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P17315 TCDB 1.B.14.1 http://www.tcdb.org/search/result.php?tc=1.B.14.1 UniProtKB CIRA_ECOLI http://www.uniprot.org/uniprot/CIRA_ECOLI UniProtKB-AC P17315 http://www.uniprot.org/uniprot/P17315 charge swissprot:CIRA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CIRA_ECOLI eggNOG COG4771 http://eggnogapi.embl.de/nog_data/html/tree/COG4771 eggNOG ENOG4105D05 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D05 epestfind swissprot:CIRA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CIRA_ECOLI garnier swissprot:CIRA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CIRA_ECOLI helixturnhelix swissprot:CIRA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CIRA_ECOLI hmoment swissprot:CIRA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CIRA_ECOLI iep swissprot:CIRA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CIRA_ECOLI inforesidue swissprot:CIRA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CIRA_ECOLI octanol swissprot:CIRA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CIRA_ECOLI pepcoil swissprot:CIRA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CIRA_ECOLI pepdigest swissprot:CIRA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CIRA_ECOLI pepinfo swissprot:CIRA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CIRA_ECOLI pepnet swissprot:CIRA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CIRA_ECOLI pepstats swissprot:CIRA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CIRA_ECOLI pepwheel swissprot:CIRA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CIRA_ECOLI pepwindow swissprot:CIRA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CIRA_ECOLI sigcleave swissprot:CIRA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CIRA_ECOLI ## Database ID URL or Descriptions # AltName FECC_ECOLI Iron(III) dicitrate transport system permease protein FecC # BioGrid 4262741 354 # EcoGene EG10288 fecC # FUNCTION FECC_ECOLI Part of the binding-protein-dependent transport system for citrate-dependent Fe(3+). Probably responsible for the translocation of the substrate across the membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005215 transporter activity; IEA:InterPro. # GO_process GO:0006811 ion transport; IEA:UniProtKB-KW. # GO_process GO:0055072 iron ion homeostasis; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006810 transport # GOslim_process GO:0042592 homeostatic process # Gene3D 1.10.3470.10 -; 1. # INDUCTION Induced 1.8-fold by hydroxyurea. {ECO:0000269|PubMed 20005847}. # InterPro IPR000522 ABC_transptr_FecCD # InterPro IPR029022 ABC_BtuC-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00240 Iron complex transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism FECC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30472 PTHR30472 # PATRIC 32124157 VBIEscCol129921_4422 # PIR S56514 QRECD1 # Pfam PF01032 FecCD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FECC_ECOLI Fe(3+) dicitrate transport system permease protein FecC # RefSeq NP_418709 NC_000913.3 # RefSeq WP_000125187 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION FECC_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF81345 SSF81345 # TCDB 3.A.1.14 the atp-binding cassette (abc) superfamily # eggNOG COG0609 LUCA # eggNOG ENOG4105DQ5 Bacteria BLAST swissprot:FECC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FECC_ECOLI BioCyc ECOL316407:JW4249-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4249-MONOMER BioCyc EcoCyc:FECC-MONOMER http://biocyc.org/getid?id=EcoCyc:FECC-MONOMER BioCyc MetaCyc:FECC-MONOMER http://biocyc.org/getid?id=MetaCyc:FECC-MONOMER COG COG0609 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0609 DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M26397 http://www.ebi.ac.uk/ena/data/view/M26397 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB0284 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0284 EcoGene EG10288 http://www.ecogene.org/geneInfo.php?eg_id=EG10288 EnsemblBacteria AAC77245 http://www.ensemblgenomes.org/id/AAC77245 EnsemblBacteria AAC77245 http://www.ensemblgenomes.org/id/AAC77245 EnsemblBacteria BAE78280 http://www.ensemblgenomes.org/id/BAE78280 EnsemblBacteria BAE78280 http://www.ensemblgenomes.org/id/BAE78280 EnsemblBacteria BAE78280 http://www.ensemblgenomes.org/id/BAE78280 EnsemblBacteria b4289 http://www.ensemblgenomes.org/id/b4289 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_process GO:0006811 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811 GO_process GO:0055072 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055072 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 Gene3D 1.10.3470.10 http://www.cathdb.info/version/latest/superfamily/1.10.3470.10 GeneID 948826 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948826 HOGENOM HOG000045410 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000045410&db=HOGENOM6 InParanoid P15030 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P15030 InterPro IPR000522 http://www.ebi.ac.uk/interpro/entry/IPR000522 InterPro IPR029022 http://www.ebi.ac.uk/interpro/entry/IPR029022 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW4249 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4249 KEGG_Gene eco:b4289 http://www.genome.jp/dbget-bin/www_bget?eco:b4289 KEGG_Orthology KO:K02015 http://www.genome.jp/dbget-bin/www_bget?KO:K02015 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA MAHVRAL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MAHVRAL PANTHER PTHR30472 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30472 PSORT swissprot:FECC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FECC_ECOLI PSORT-B swissprot:FECC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FECC_ECOLI PSORT2 swissprot:FECC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FECC_ECOLI Pfam PF01032 http://pfam.xfam.org/family/PF01032 Phobius swissprot:FECC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FECC_ECOLI PhylomeDB P15030 http://phylomedb.org/?seqid=P15030 ProteinModelPortal P15030 http://www.proteinmodelportal.org/query/uniprot/P15030 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 2651410 http://www.ncbi.nlm.nih.gov/pubmed/2651410 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418709 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418709 RefSeq WP_000125187 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000125187 STRING 511145.b4289 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4289&targetmode=cogs STRING COG0609 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0609&targetmode=cogs SUPFAM SSF81345 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81345 TCDB 3.A.1.14 http://www.tcdb.org/search/result.php?tc=3.A.1.14 UniProtKB FECC_ECOLI http://www.uniprot.org/uniprot/FECC_ECOLI UniProtKB-AC P15030 http://www.uniprot.org/uniprot/P15030 charge swissprot:FECC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FECC_ECOLI eggNOG COG0609 http://eggnogapi.embl.de/nog_data/html/tree/COG0609 eggNOG ENOG4105DQ5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DQ5 epestfind swissprot:FECC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FECC_ECOLI garnier swissprot:FECC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FECC_ECOLI helixturnhelix swissprot:FECC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FECC_ECOLI hmoment swissprot:FECC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FECC_ECOLI iep swissprot:FECC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FECC_ECOLI inforesidue swissprot:FECC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FECC_ECOLI octanol swissprot:FECC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FECC_ECOLI pepcoil swissprot:FECC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FECC_ECOLI pepdigest swissprot:FECC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FECC_ECOLI pepinfo swissprot:FECC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FECC_ECOLI pepnet swissprot:FECC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FECC_ECOLI pepstats swissprot:FECC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FECC_ECOLI pepwheel swissprot:FECC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FECC_ECOLI pepwindow swissprot:FECC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FECC_ECOLI sigcleave swissprot:FECC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FECC_ECOLI ## Database ID URL or Descriptions # AltName GNTR_ECOLI Gluconate utilization system GNT-I transcriptional repressor # BioGrid 4259299 13 # CDD cd01392 HTH_LacI # EcoGene EG12630 gntR # FUNCTION GNTR_ECOLI Negative regulator for the gluconate utilization system GNT-I, the gntUKR operon. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0046177 D-gluconate catabolic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.260.40 -; 1. # InterPro IPR000843 HTH_LacI # InterPro IPR001761 Peripla_BP/Lac1_sug-bd_dom # InterPro IPR010982 Lambda_DNA-bd_dom # InterPro IPR028082 Peripla_BP_I # KEGG_Brite ko03000 Transcription factors # Organism GNTR_ECOLI Escherichia coli (strain K12) # PATHWAY GNTR_ECOLI Carbohydrate acid metabolism; D-gluconate degradation [regulation]. # PATRIC 32122314 VBIEscCol129921_3534 # PIR A65140 A65140 # PROSITE PS00356 HTH_LACI_1 # PROSITE PS50932 HTH_LACI_2 # Pfam PF00356 LacI # Pfam PF00532 Peripla_BP_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GNTR_ECOLI HTH-type transcriptional regulator GntR # RefSeq WP_000730252 NZ_LN832404.1 # RefSeq YP_026222 NC_000913.3 # SIMILARITY Contains 1 HTH lacI-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00111}. # SMART SM00354 HTH_LACI # SUPFAM SSF47413 SSF47413 # SUPFAM SSF53822 SSF53822 # eggNOG ENOG4105DIQ Bacteria # eggNOG ENOG410XPSF LUCA BLAST swissprot:GNTR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GNTR_ECOLI BioCyc ECOL316407:JW5946-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5946-MONOMER BioCyc EcoCyc:PD03585 http://biocyc.org/getid?id=EcoCyc:PD03585 COG COG1609 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1609 DIP DIP-9822N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9822N DOI 10.1006/jmbi.1996.0913 http://dx.doi.org/10.1006/jmbi.1996.0913 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D84362 http://www.ebi.ac.uk/ena/data/view/D84362 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2514 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2514 EcoGene EG12630 http://www.ecogene.org/geneInfo.php?eg_id=EG12630 EnsemblBacteria AAT48184 http://www.ensemblgenomes.org/id/AAT48184 EnsemblBacteria AAT48184 http://www.ensemblgenomes.org/id/AAT48184 EnsemblBacteria BAE77855 http://www.ensemblgenomes.org/id/BAE77855 EnsemblBacteria BAE77855 http://www.ensemblgenomes.org/id/BAE77855 EnsemblBacteria BAE77855 http://www.ensemblgenomes.org/id/BAE77855 EnsemblBacteria b3438 http://www.ensemblgenomes.org/id/b3438 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GO_process GO:0046177 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046177 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.260.40 http://www.cathdb.info/version/latest/superfamily/1.10.260.40 GeneID 947946 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947946 HOGENOM HOG000220181 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220181&db=HOGENOM6 InParanoid P0ACP5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACP5 InterPro IPR000843 http://www.ebi.ac.uk/interpro/entry/IPR000843 InterPro IPR001761 http://www.ebi.ac.uk/interpro/entry/IPR001761 InterPro IPR010982 http://www.ebi.ac.uk/interpro/entry/IPR010982 InterPro IPR028082 http://www.ebi.ac.uk/interpro/entry/IPR028082 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW5946 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5946 KEGG_Gene eco:b3438 http://www.genome.jp/dbget-bin/www_bget?eco:b3438 KEGG_Orthology KO:K06145 http://www.genome.jp/dbget-bin/www_bget?KO:K06145 OMA MESIVAH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MESIVAH PROSITE PS00356 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00356 PROSITE PS50932 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50932 PSORT swissprot:GNTR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GNTR_ECOLI PSORT-B swissprot:GNTR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GNTR_ECOLI PSORT2 swissprot:GNTR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GNTR_ECOLI Pfam PF00356 http://pfam.xfam.org/family/PF00356 Pfam PF00532 http://pfam.xfam.org/family/PF00532 Phobius swissprot:GNTR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GNTR_ECOLI PhylomeDB P0ACP5 http://phylomedb.org/?seqid=P0ACP5 ProteinModelPortal P0ACP5 http://www.proteinmodelportal.org/query/uniprot/P0ACP5 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8655507 http://www.ncbi.nlm.nih.gov/pubmed/8655507 PubMed 9135111 http://www.ncbi.nlm.nih.gov/pubmed/9135111 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000730252 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000730252 RefSeq YP_026222 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026222 SMART SM00354 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00354 SMR P0ACP5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACP5 STRING 511145.b3438 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3438&targetmode=cogs STRING COG1609 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1609&targetmode=cogs SUPFAM SSF47413 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47413 SUPFAM SSF53822 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822 UniProtKB GNTR_ECOLI http://www.uniprot.org/uniprot/GNTR_ECOLI UniProtKB-AC P0ACP5 http://www.uniprot.org/uniprot/P0ACP5 charge swissprot:GNTR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GNTR_ECOLI eggNOG ENOG4105DIQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DIQ eggNOG ENOG410XPSF http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPSF epestfind swissprot:GNTR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GNTR_ECOLI garnier swissprot:GNTR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GNTR_ECOLI helixturnhelix swissprot:GNTR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GNTR_ECOLI hmoment swissprot:GNTR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GNTR_ECOLI iep swissprot:GNTR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GNTR_ECOLI inforesidue swissprot:GNTR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GNTR_ECOLI octanol swissprot:GNTR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GNTR_ECOLI pepcoil swissprot:GNTR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GNTR_ECOLI pepdigest swissprot:GNTR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GNTR_ECOLI pepinfo swissprot:GNTR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GNTR_ECOLI pepnet swissprot:GNTR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GNTR_ECOLI pepstats swissprot:GNTR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GNTR_ECOLI pepwheel swissprot:GNTR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GNTR_ECOLI pepwindow swissprot:GNTR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GNTR_ECOLI sigcleave swissprot:GNTR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GNTR_ECOLI ## Database ID URL or Descriptions # AltName YIGL_ECOLI PLP phosphatase # AltName YIGL_ECOLI Sugar phosphatase # BIOPHYSICOCHEMICAL PROPERTIES YIGL_ECOLI Kinetic parameters KM=1.5 mM for PLP (in the presence of magnesium ion as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; KM=5.9 mM for bGlu6P (in the presence of magnesium ion as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; KM=7.5 mM for 2bGLU6P (in the presence of magnesium ion as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; pH dependence Optimum pH is between 6 and 7.5. {ECO 0000269|PubMed 16990279}; # BioGrid 4259609 11 # CATALYTIC ACTIVITY Pyridoxal 5'-phosphate + H(2)O = pyridoxal + phosphate. {ECO:0000269|PubMed 16990279}. # CATALYTIC ACTIVITY Sugar phosphate + H(2)O = sugar + phosphate. {ECO:0000269|PubMed 16990279}. # COFACTOR YIGL_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 16990279}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 16990279}; Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000269|PubMed 16990279}; Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 16990279}; Note=Magnesium. Can also use other divalent metal cations as manganese, cobalt or zinc. {ECO 0000269|PubMed 16990279}; # EcoGene EG11470 yigL # FUNCTION YIGL_ECOLI Catalyzes Strongly the dephosphorylation of pyridoxal- phosphate (PLP) and moderately the dephosphorylation of 2- deoxyglucose 6-phosphate (2bGLU6P) and beta-glucose 6-phosphate (bGlu6P). Also hydrolyzes both purines (GMP and IMP) and pyrimidines as secondary substrates. {ECO 0000269|PubMed 16990279}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IDA:UniProtKB. # GO_function GO:0016791 phosphatase activity; IDA:EcoliWiki. # GO_function GO:0033883 pyridoxal phosphatase activity; IDA:EcoliWiki. # GO_function GO:0046872 metal ion binding; IDA:EcoliWiki. # GO_function GO:0050308 sugar-phosphatase activity; IDA:EcoliWiki. # GO_process GO:0044283 small molecule biosynthetic process; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.1000 -; 2. # IntAct P27848 2 # InterPro IPR000150 Hypothet_cof # InterPro IPR006379 HAD-SF_hydro_IIB # InterPro IPR023214 HAD-like_dom # Organism YIGL_ECOLI Escherichia coli (strain K12) # PATRIC 32123153 VBIEscCol129921_3942 # PROSITE PS01228 COF_1 # PROSITE PS01229 COF_2 # Pfam PF08282 Hydrolase_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIGL_ECOLI Pyridoxal phosphate phosphatase YigL # RefSeq WP_000285362 NZ_LN832404.1 # RefSeq YP_026267 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA67622.1; Type=Frameshift; Positions=Several; Evidence={ECO 0000305}; # SIMILARITY Belongs to the HAD-like hydrolase superfamily. Cof family. {ECO 0000305}. # SUPFAM SSF56784 SSF56784 # TIGRFAMs TIGR00099 Cof-subfamily # TIGRFAMs TIGR01484 HAD-SF-IIB # eggNOG COG0561 LUCA # eggNOG ENOG4105DQF Bacteria BLAST swissprot:YIGL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIGL_ECOLI BioCyc ECOL316407:JW5854-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5854-MONOMER BioCyc EcoCyc:EG11470-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11470-MONOMER BioCyc MetaCyc:EG11470-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11470-MONOMER COG COG0561 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0561 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M605449200 http://dx.doi.org/10.1074/jbc.M605449200 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.3.23 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.23 EC_number EC:3.1.3.74 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.74 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X03155 http://www.ebi.ac.uk/ena/data/view/X03155 ENZYME 3.1.3.23 http://enzyme.expasy.org/EC/3.1.3.23 ENZYME 3.1.3.74 http://enzyme.expasy.org/EC/3.1.3.74 EchoBASE EB1438 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1438 EcoGene EG11470 http://www.ecogene.org/geneInfo.php?eg_id=EG11470 EnsemblBacteria AAT48225 http://www.ensemblgenomes.org/id/AAT48225 EnsemblBacteria AAT48225 http://www.ensemblgenomes.org/id/AAT48225 EnsemblBacteria BAE77475 http://www.ensemblgenomes.org/id/BAE77475 EnsemblBacteria BAE77475 http://www.ensemblgenomes.org/id/BAE77475 EnsemblBacteria BAE77475 http://www.ensemblgenomes.org/id/BAE77475 EnsemblBacteria b3826 http://www.ensemblgenomes.org/id/b3826 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GO_function GO:0033883 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033883 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0050308 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050308 GO_process GO:0044283 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044283 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.1000 http://www.cathdb.info/version/latest/superfamily/3.40.50.1000 GeneID 2847768 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2847768 HOGENOM HOG000184784 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000184784&db=HOGENOM6 InParanoid P27848 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P27848 IntAct P27848 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P27848* IntEnz 3.1.3.23 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.23 IntEnz 3.1.3.74 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.74 InterPro IPR000150 http://www.ebi.ac.uk/interpro/entry/IPR000150 InterPro IPR006379 http://www.ebi.ac.uk/interpro/entry/IPR006379 InterPro IPR023214 http://www.ebi.ac.uk/interpro/entry/IPR023214 KEGG_Gene ecj:JW5854 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5854 KEGG_Gene eco:b3826 http://www.genome.jp/dbget-bin/www_bget?eco:b3826 KEGG_Orthology KO:K07024 http://www.genome.jp/dbget-bin/www_bget?KO:K07024 OMA RHHVDVA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RHHVDVA PROSITE PS01228 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01228 PROSITE PS01229 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01229 PSORT swissprot:YIGL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIGL_ECOLI PSORT-B swissprot:YIGL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIGL_ECOLI PSORT2 swissprot:YIGL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIGL_ECOLI Pfam PF08282 http://pfam.xfam.org/family/PF08282 Phobius swissprot:YIGL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIGL_ECOLI PhylomeDB P27848 http://phylomedb.org/?seqid=P27848 ProteinModelPortal P27848 http://www.proteinmodelportal.org/query/uniprot/P27848 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16990279 http://www.ncbi.nlm.nih.gov/pubmed/16990279 PubMed 3908445 http://www.ncbi.nlm.nih.gov/pubmed/3908445 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000285362 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000285362 RefSeq YP_026267 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026267 SMR P27848 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P27848 STRING 511145.b3826 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3826&targetmode=cogs STRING COG0561 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0561&targetmode=cogs SUPFAM SSF56784 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784 TIGRFAMs TIGR00099 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00099 TIGRFAMs TIGR01484 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01484 UniProtKB YIGL_ECOLI http://www.uniprot.org/uniprot/YIGL_ECOLI UniProtKB-AC P27848 http://www.uniprot.org/uniprot/P27848 charge swissprot:YIGL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIGL_ECOLI eggNOG COG0561 http://eggnogapi.embl.de/nog_data/html/tree/COG0561 eggNOG ENOG4105DQF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DQF epestfind swissprot:YIGL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIGL_ECOLI garnier swissprot:YIGL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIGL_ECOLI helixturnhelix swissprot:YIGL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIGL_ECOLI hmoment swissprot:YIGL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIGL_ECOLI iep swissprot:YIGL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIGL_ECOLI inforesidue swissprot:YIGL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIGL_ECOLI octanol swissprot:YIGL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIGL_ECOLI pepcoil swissprot:YIGL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIGL_ECOLI pepdigest swissprot:YIGL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIGL_ECOLI pepinfo swissprot:YIGL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIGL_ECOLI pepnet swissprot:YIGL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIGL_ECOLI pepstats swissprot:YIGL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIGL_ECOLI pepwheel swissprot:YIGL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIGL_ECOLI pepwindow swissprot:YIGL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIGL_ECOLI sigcleave swissprot:YIGL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIGL_ECOLI ## Database ID URL or Descriptions # AltName RLMF_ECOLI 23S rRNA mA1618 methyltransferase # AltName RLMF_ECOLI rRNA adenine N-6-methyltransferase # BRENDA 2.1.1.181 2026 # BioGrid 4259969 7 # CATALYTIC ACTIVITY RLMF_ECOLI S-adenosyl-L-methionine + adenine(1618) in 23S rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)- methyladenine(1618) in 23S rRNA. # EcoGene EG13319 rlmF # FUNCTION RLMF_ECOLI Specifically methylates the adenine in position 1618 of 23S rRNA. {ECO 0000269|PubMed 18021804}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0052907 23S rRNA (adenine(1618)-N(6))-methyltransferase activity; IDA:EcoCyc. # GO_process GO:0070475 rRNA base methylation; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.50.150 -; 1. # HAMAP MF_01848 23SrRNA_methyltr_F # InterPro IPR010286 rRNA_lsu_MeTfrase_F-like # InterPro IPR016909 rRNA_lsu_MeTfrase_F # InterPro IPR029063 SAM-dependent_MTases # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # MISCELLANEOUS RLMF_ECOLI Recombinant protein is able to methylate partially deproteinized 50S ribosomal subunit, but neither the completely assembled 50S subunits nor completely deproteinized 23S rRNA. # Organism RLMF_ECOLI Escherichia coli (strain K12) # PANTHER PTHR13393 PTHR13393 # PATRIC 32116817 VBIEscCol129921_0834 # PIR G64817 G64817 # PIRSF PIRSF029038 Mtase_YbiN_prd # Pfam PF05971 Methyltransf_10 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RLMF_ECOLI Ribosomal RNA large subunit methyltransferase F # RefSeq NP_415328 NC_000913.3 # RefSeq WP_001295299 NZ_LN832404.1 # SIMILARITY Belongs to the methyltransferase superfamily. METTL16/RlmF family. {ECO 0000305}. # SUBCELLULAR LOCATION RLMF_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF53335 SSF53335 # eggNOG COG3129 LUCA # eggNOG ENOG4105EBA Bacteria BLAST swissprot:RLMF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RLMF_ECOLI BioCyc ECOL316407:JW5107-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5107-MONOMER BioCyc EcoCyc:G6416-MONOMER http://biocyc.org/getid?id=EcoCyc:G6416-MONOMER BioCyc MetaCyc:G6416-MONOMER http://biocyc.org/getid?id=MetaCyc:G6416-MONOMER COG COG3129 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3129 DIP DIP-11434N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11434N DOI 10.1016/j.jmb.2007.10.051 http://dx.doi.org/10.1016/j.jmb.2007.10.051 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.1.181 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.181 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.1.1.181 http://enzyme.expasy.org/EC/2.1.1.181 EchoBASE EB3103 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3103 EcoGene EG13319 http://www.ecogene.org/geneInfo.php?eg_id=EG13319 EnsemblBacteria AAC73894 http://www.ensemblgenomes.org/id/AAC73894 EnsemblBacteria AAC73894 http://www.ensemblgenomes.org/id/AAC73894 EnsemblBacteria BAA35473 http://www.ensemblgenomes.org/id/BAA35473 EnsemblBacteria BAA35473 http://www.ensemblgenomes.org/id/BAA35473 EnsemblBacteria BAA35473 http://www.ensemblgenomes.org/id/BAA35473 EnsemblBacteria b0807 http://www.ensemblgenomes.org/id/b0807 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0052907 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052907 GO_process GO:0070475 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070475 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 GeneID 944938 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944938 HAMAP MF_01848 http://hamap.expasy.org/unirule/MF_01848 HOGENOM HOG000218605 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218605&db=HOGENOM6 InParanoid P75782 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75782 IntAct P75782 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75782* IntEnz 2.1.1.181 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.181 InterPro IPR010286 http://www.ebi.ac.uk/interpro/entry/IPR010286 InterPro IPR016909 http://www.ebi.ac.uk/interpro/entry/IPR016909 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW5107 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5107 KEGG_Gene eco:b0807 http://www.genome.jp/dbget-bin/www_bget?eco:b0807 KEGG_Orthology KO:K06970 http://www.genome.jp/dbget-bin/www_bget?KO:K06970 KEGG_Reaction rn:R07232 http://www.genome.jp/dbget-bin/www_bget?rn:R07232 MINT MINT-1267834 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1267834 OMA TEFHQGH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TEFHQGH PANTHER PTHR13393 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13393 PSORT swissprot:RLMF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RLMF_ECOLI PSORT-B swissprot:RLMF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RLMF_ECOLI PSORT2 swissprot:RLMF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RLMF_ECOLI Pfam PF05971 http://pfam.xfam.org/family/PF05971 Phobius swissprot:RLMF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RLMF_ECOLI PhylomeDB P75782 http://phylomedb.org/?seqid=P75782 ProteinModelPortal P75782 http://www.proteinmodelportal.org/query/uniprot/P75782 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18021804 http://www.ncbi.nlm.nih.gov/pubmed/18021804 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415328 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415328 RefSeq WP_001295299 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295299 SMR P75782 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75782 STRING 511145.b0807 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0807&targetmode=cogs STRING COG3129 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3129&targetmode=cogs SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 UniProtKB RLMF_ECOLI http://www.uniprot.org/uniprot/RLMF_ECOLI UniProtKB-AC P75782 http://www.uniprot.org/uniprot/P75782 charge swissprot:RLMF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RLMF_ECOLI eggNOG COG3129 http://eggnogapi.embl.de/nog_data/html/tree/COG3129 eggNOG ENOG4105EBA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EBA epestfind swissprot:RLMF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RLMF_ECOLI garnier swissprot:RLMF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RLMF_ECOLI helixturnhelix swissprot:RLMF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RLMF_ECOLI hmoment swissprot:RLMF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RLMF_ECOLI iep swissprot:RLMF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RLMF_ECOLI inforesidue swissprot:RLMF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RLMF_ECOLI octanol swissprot:RLMF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RLMF_ECOLI pepcoil swissprot:RLMF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RLMF_ECOLI pepdigest swissprot:RLMF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RLMF_ECOLI pepinfo swissprot:RLMF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RLMF_ECOLI pepnet swissprot:RLMF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RLMF_ECOLI pepstats swissprot:RLMF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RLMF_ECOLI pepwheel swissprot:RLMF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RLMF_ECOLI pepwindow swissprot:RLMF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RLMF_ECOLI sigcleave swissprot:RLMF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RLMF_ECOLI ## Database ID URL or Descriptions # BioGrid 4259786 3 # CDD cd00207 fer2 # EcoGene EG13559 yagT # FUNCTION YAGT_ECOLI Iron-sulfur subunit of the xanthine dehydrogenase complex. {ECO 0000250}. # GO_component GO:0042597 periplasmic space; IDA:EcoCyc. # GO_function GO:0009055 electron carrier activity; IEA:InterPro. # GO_function GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051537 2 iron, 2 sulfur cluster binding; IDA:EcoCyc. # GO_process GO:0006144 purine nucleobase metabolic process; IEA:UniProtKB-KW. # GO_process GO:0006166 purine ribonucleoside salvage; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.150.120 -; 1. # Gene3D 3.10.20.30 -; 1. # INTERACTION YAGT_ECOLI P0AFM2 proX; NbExp=2; IntAct=EBI-1115563, EBI-1129961; # IntAct P77165 10 # InterPro IPR001041 2Fe-2S_ferredoxin-type # InterPro IPR002888 2Fe-2S-bd # InterPro IPR006058 2Fe2S_fd_BS # InterPro IPR006311 TAT_signal # InterPro IPR012675 Beta-grasp_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Pathway ko00230 Purine metabolism # Organism YAGT_ECOLI Escherichia coli (strain K12) # PATRIC 32115695 VBIEscCol129921_0290 # PDB 5G5G X-ray; 1.70 A; A=1-229 # PDB 5G5H X-ray; 2.30 A; A=1-229 # PIR F64754 F64754 # PROSITE PS00197 2FE2S_FER_1 # PROSITE PS51085 2FE2S_FER_2 # PROSITE PS51318 TAT # PTM YAGT_ECOLI Exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven. # Pfam PF00111 Fer2 # Pfam PF01799 Fer2_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAGT_ECOLI Putative xanthine dehydrogenase YagT iron-sulfur-binding subunit # RefSeq NP_414820 NC_000913.3 # RefSeq WP_000070700 NZ_LN832404.1 # SIMILARITY Contains 1 2Fe-2S ferredoxin-type domain. {ECO:0000255|PROSITE-ProRule PRU00465}. # SUBUNIT Heterotrimer of YagR, YagS and YagT. {ECO 0000305}. # SUPFAM SSF47741 SSF47741 # SUPFAM SSF54292 SSF54292 # eggNOG COG2080 LUCA # eggNOG ENOG4107XKX Bacteria BLAST swissprot:YAGT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAGT_ECOLI BioCyc ECOL316407:JW0280-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0280-MONOMER BioCyc EcoCyc:G6157-MONOMER http://biocyc.org/getid?id=EcoCyc:G6157-MONOMER BioCyc MetaCyc:G6157-MONOMER http://biocyc.org/getid?id=MetaCyc:G6157-MONOMER COG COG2080 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2080 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M610507200 http://dx.doi.org/10.1074/jbc.M610507200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB3329 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3329 EcoGene EG13559 http://www.ecogene.org/geneInfo.php?eg_id=EG13559 EnsemblBacteria AAC73389 http://www.ensemblgenomes.org/id/AAC73389 EnsemblBacteria AAC73389 http://www.ensemblgenomes.org/id/AAC73389 EnsemblBacteria BAE76070 http://www.ensemblgenomes.org/id/BAE76070 EnsemblBacteria BAE76070 http://www.ensemblgenomes.org/id/BAE76070 EnsemblBacteria BAE76070 http://www.ensemblgenomes.org/id/BAE76070 EnsemblBacteria b0286 http://www.ensemblgenomes.org/id/b0286 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0016903 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016903 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051537 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051537 GO_process GO:0006144 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006144 GO_process GO:0006166 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006166 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.150.120 http://www.cathdb.info/version/latest/superfamily/1.10.150.120 Gene3D 3.10.20.30 http://www.cathdb.info/version/latest/superfamily/3.10.20.30 GeneID 945330 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945330 HOGENOM HOG000166647 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000166647&db=HOGENOM6 InParanoid P77165 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77165 IntAct P77165 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77165* InterPro IPR001041 http://www.ebi.ac.uk/interpro/entry/IPR001041 InterPro IPR002888 http://www.ebi.ac.uk/interpro/entry/IPR002888 InterPro IPR006058 http://www.ebi.ac.uk/interpro/entry/IPR006058 InterPro IPR006311 http://www.ebi.ac.uk/interpro/entry/IPR006311 InterPro IPR012675 http://www.ebi.ac.uk/interpro/entry/IPR012675 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Gene ecj:JW0280 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0280 KEGG_Gene eco:b0286 http://www.genome.jp/dbget-bin/www_bget?eco:b0286 KEGG_Orthology KO:K13483 http://www.genome.jp/dbget-bin/www_bget?KO:K13483 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Reaction rn:R01768 http://www.genome.jp/dbget-bin/www_bget?rn:R01768 KEGG_Reaction rn:R02103 http://www.genome.jp/dbget-bin/www_bget?rn:R02103 OMA LDGYQCG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LDGYQCG PDB 5G5G http://www.ebi.ac.uk/pdbe-srv/view/entry/5G5G PDB 5G5H http://www.ebi.ac.uk/pdbe-srv/view/entry/5G5H PDBsum 5G5G http://www.ebi.ac.uk/pdbsum/5G5G PDBsum 5G5H http://www.ebi.ac.uk/pdbsum/5G5H PROSITE PS00197 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00197 PROSITE PS51085 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51085 PROSITE PS51318 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51318 PSORT swissprot:YAGT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAGT_ECOLI PSORT-B swissprot:YAGT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAGT_ECOLI PSORT2 swissprot:YAGT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAGT_ECOLI Pfam PF00111 http://pfam.xfam.org/family/PF00111 Pfam PF01799 http://pfam.xfam.org/family/PF01799 Phobius swissprot:YAGT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAGT_ECOLI PhylomeDB P77165 http://phylomedb.org/?seqid=P77165 ProteinModelPortal P77165 http://www.proteinmodelportal.org/query/uniprot/P77165 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17218314 http://www.ncbi.nlm.nih.gov/pubmed/17218314 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414820 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414820 RefSeq WP_000070700 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000070700 SMR P77165 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77165 STRING 511145.b0286 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0286&targetmode=cogs STRING COG2080 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2080&targetmode=cogs SUPFAM SSF47741 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47741 SUPFAM SSF54292 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54292 UniProtKB YAGT_ECOLI http://www.uniprot.org/uniprot/YAGT_ECOLI UniProtKB-AC P77165 http://www.uniprot.org/uniprot/P77165 charge swissprot:YAGT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAGT_ECOLI eggNOG COG2080 http://eggnogapi.embl.de/nog_data/html/tree/COG2080 eggNOG ENOG4107XKX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107XKX epestfind swissprot:YAGT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAGT_ECOLI garnier swissprot:YAGT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAGT_ECOLI helixturnhelix swissprot:YAGT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAGT_ECOLI hmoment swissprot:YAGT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAGT_ECOLI iep swissprot:YAGT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAGT_ECOLI inforesidue swissprot:YAGT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAGT_ECOLI octanol swissprot:YAGT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAGT_ECOLI pepcoil swissprot:YAGT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAGT_ECOLI pepdigest swissprot:YAGT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAGT_ECOLI pepinfo swissprot:YAGT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAGT_ECOLI pepnet swissprot:YAGT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAGT_ECOLI pepstats swissprot:YAGT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAGT_ECOLI pepwheel swissprot:YAGT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAGT_ECOLI pepwindow swissprot:YAGT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAGT_ECOLI sigcleave swissprot:YAGT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAGT_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES DMSA_ECOLI Kinetic parameters KM=0.043 mM for 2-chloropyridine N-oxide (at pH 5 and at 30 degrees Celsius, PubMed 8969520) {ECO 0000269|PubMed 3280546, ECO 0000269|PubMed 8969520}; KM=0.045 mM for 3-amidopyridine N-oxide (at pH 5 and at 30 degrees Celsius, PubMed 8969520) {ECO 0000269|PubMed 3280546, ECO 0000269|PubMed 8969520}; KM=0.06 mM for tertramethylene sulfoxide (at pH 5 and at 30 degrees Celsius, PubMed 8969520) {ECO 0000269|PubMed 3280546, ECO 0000269|PubMed 8969520}; KM=0.09 mM for methionine sulfoxide (at pH 5 and at 30 degrees Celsius, PubMed 8969520) {ECO 0000269|PubMed 3280546, ECO 0000269|PubMed 8969520}; KM=0.246 mM for 4-phenylpyridine N-oxide (at pH 5 and at 30 degrees Celsius, PubMed 8969520) {ECO 0000269|PubMed 3280546, ECO 0000269|PubMed 8969520}; KM=0.830 mM for dimethyldodecylamin N-oxide (at pH 5 and at 30 degrees Celsius, PubMed 8969520) {ECO 0000269|PubMed 3280546, ECO 0000269|PubMed 8969520}; KM=0.18 mM for DMSO (at pH 6.8 and at 23 degrees Celsius, PubMed 3280546) {ECO 0000269|PubMed 3280546, ECO 0000269|PubMed 8969520}; KM=0.47 mM for L-methionine sulfoxide (at pH 6.8 and at 23 degrees Celsius, PubMed 3280546) {ECO 0000269|PubMed 3280546, ECO 0000269|PubMed 8969520}; KM=0.5 mM for nicotinamide N-oxide (at pH 6.8 and at 23 degrees Celsius, PubMed 3280546) {ECO 0000269|PubMed 3280546, ECO 0000269|PubMed 8969520}; KM=0.6 mM for TMAO (at pH 6.8 and at 23 degrees Celsius, PubMed 3280546) {ECO 0000269|PubMed 3280546, ECO 0000269|PubMed 8969520}; KM=1.0 mM for 4-picoline N-oxide (at pH 6.8 and at 23 degrees Celsius, PubMed 3280546) {ECO 0000269|PubMed 3280546, ECO 0000269|PubMed 8969520}; KM=20.2 mM for TMAO (at pH 5 and at 30 degrees Celsius, PubMed 8969520) {ECO 0000269|PubMed 3280546, ECO 0000269|PubMed 8969520}; # BRENDA 1.8.5 2026 # BioGrid 4261945 15 # CATALYTIC ACTIVITY DMSA_ECOLI Dimethylsulfide + menaquinone + H(2)O = dimethylsulfoxide + menaquinol. # COFACTOR DMSA_ECOLI Name=Mo-bis(molybdopterin guanine dinucleotide); Xref=ChEBI CHEBI 60539; Evidence={ECO 0000269|PubMed 10224050, ECO 0000269|PubMed 3280546, ECO 0000269|PubMed 7721698}; Note=Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit. {ECO 0000269|PubMed 10224050, ECO 0000269|PubMed 3280546, ECO 0000269|PubMed 7721698}; # COFACTOR DMSA_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000305}; Note=Binds 1 [4Fe-4S] cluster. {ECO 0000305}; # ENZYME REGULATION DMSA_ECOLI Inhibited by dithionite, sodium hydrogensulfite and tungstate. {ECO 0000269|PubMed 7721698, ECO 0000269|PubMed 8969520}. # EcoGene EG10232 dmsA # FUNCTION DMSA_ECOLI Catalyzes the reduction of dimethyl sulfoxide (DMSO) to dimethyl sulfide (DMS). DMSO reductase serves as the terminal reductase under anaerobic conditions, with DMSO being the terminal electron acceptor. Terminal reductase during anaerobic growth on various sulfoxides and N-oxide compounds. Allows E.coli to grow anaerobically on DMSO as respiratory oxidant. {ECO 0000269|PubMed 3062312}. # GO_component GO:0009390 dimethyl sulfoxide reductase complex; IDA:EcoCyc. # GO_component GO:0031237 intrinsic component of periplasmic side of plasma membrane; IDA:EcoCyc. # GO_function GO:0009055 electron carrier activity; IMP:EcoCyc. # GO_function GO:0009389 dimethyl sulfoxide reductase activity; IEA:InterPro. # GO_function GO:0030151 molybdenum ion binding; IEA:InterPro. # GO_function GO:0048037 cofactor binding; IMP:EcoCyc. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IMP:EcoCyc. # GO_process GO:0009061 anaerobic respiration; IEP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # INTERACTION DMSA_ECOLI P18776 dmsB; NbExp=2; IntAct=EBI-4411104, EBI-1120825; P69853 dmsD; NbExp=7; IntAct=EBI-4411104, EBI-4406374; # IntAct P18775 8 # InterPro IPR006311 TAT_signal # InterPro IPR006655 Mopterin_OxRdtase_prok_CS # InterPro IPR006656 Mopterin_OxRdtase # InterPro IPR006657 MoPterin_dinucl-bd_dom # InterPro IPR006963 Mopterin_OxRdtase_4Fe-4S_dom # InterPro IPR009010 Asp_de-COase-like_dom # InterPro IPR011888 Anaer_DMSO_reductase # InterPro IPR019546 TAT_signal_bac_arc # InterPro IPR027467 MopterinOxRdtase_cofactor_BS # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 Transporters # MISCELLANEOUS DMSA_ECOLI The Tat signal sequence is essential for the expression of dmsA, the stability of the DmsAB dimer and membrane targeting. Despite the presence of a signal sequence, DmsA is not exported to the periplasm. # Organism DMSA_ECOLI Escherichia coli (strain K12) # PATRIC 32116999 VBIEscCol129921_0924 # PIR S03785 S03785 # PROSITE PS00490 MOLYBDOPTERIN_PROK_2 # PROSITE PS00551 MOLYBDOPTERIN_PROK_1 # PROSITE PS00932 MOLYBDOPTERIN_PROK_3 # PROSITE PS51318 TAT # PROSITE PS51669 4FE4S_MOW_BIS_MGD # PTM DMSA_ECOLI Exported by the Tat system. The position of the signal peptide cleavage has been experimentally proven. Can also be exported by the Sec system. # Pfam PF00384 Molybdopterin # Pfam PF01568 Molydop_binding # Pfam PF04879 Molybdop_Fe4S4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DMSA_ECOLI Dimethyl sulfoxide reductase DmsA # RefSeq NP_415414 NC_000913.3 # RefSeq WP_000850303 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA83843.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. {ECO 0000305}. # SIMILARITY Contains 1 4Fe-4S Mo/W bis-MGD-type domain. {ECO:0000255|PROSITE-ProRule PRU01004}. # SMART SM00926 Molybdop_Fe4S4 # SUBCELLULAR LOCATION DMSA_ECOLI Cell membrane {ECO 0000269|PubMed 2170332, ECO 0000269|PubMed 3280546}; Peripheral membrane protein {ECO 0000269|PubMed 2170332, ECO 0000269|PubMed 3280546}; Cytoplasmic side {ECO 0000269|PubMed 2170332, ECO 0000269|PubMed 3280546}. # SUBUNIT Heterotrimeric enzyme composed of a catalytic heterodimer (DmsAB) and a membrane anchor protein (DmsC). {ECO:0000269|PubMed 3280546}. # SUPFAM SSF50692 SSF50692 # TCDB 5.A.3.3 the prokaryotic molybdopterin-containing oxidoreductase (pmo) family # TIGRFAMs TIGR01409 TAT_signal_seq # TIGRFAMs TIGR02166 dmsA_ynfE # eggNOG COG0243 LUCA # eggNOG ENOG4107QY8 Bacteria BLAST swissprot:DMSA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DMSA_ECOLI BioCyc ECOL316407:JW5118-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5118-MONOMER BioCyc EcoCyc:DMSA-MONOMER http://biocyc.org/getid?id=EcoCyc:DMSA-MONOMER BioCyc MetaCyc:DMSA-MONOMER http://biocyc.org/getid?id=MetaCyc:DMSA-MONOMER COG COG0243 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0243 DIP DIP-9452N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9452N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.274.19.13002 http://dx.doi.org/10.1074/jbc.274.19.13002 DOI 10.1074/jbc.M610507200 http://dx.doi.org/10.1074/jbc.M610507200 DOI 10.1074/jbc.M909289199 http://dx.doi.org/10.1074/jbc.M909289199 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1099/13500872-142-11-3231 http://dx.doi.org/10.1099/13500872-142-11-3231 DOI 10.1111/j.1365-2958.1988.tb00090.x http://dx.doi.org/10.1111/j.1365-2958.1988.tb00090.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pone.0009225 http://dx.doi.org/10.1371/journal.pone.0009225 EC_number EC:1.8.5.3 http://www.genome.jp/dbget-bin/www_bget?EC:1.8.5.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J03412 http://www.ebi.ac.uk/ena/data/view/J03412 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.8.5.3 http://enzyme.expasy.org/EC/1.8.5.3 EchoBASE EB0228 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0228 EcoGene EG10232 http://www.ecogene.org/geneInfo.php?eg_id=EG10232 EnsemblBacteria AAC73980 http://www.ensemblgenomes.org/id/AAC73980 EnsemblBacteria AAC73980 http://www.ensemblgenomes.org/id/AAC73980 EnsemblBacteria BAA35626 http://www.ensemblgenomes.org/id/BAA35626 EnsemblBacteria BAA35626 http://www.ensemblgenomes.org/id/BAA35626 EnsemblBacteria BAA35626 http://www.ensemblgenomes.org/id/BAA35626 EnsemblBacteria b0894 http://www.ensemblgenomes.org/id/b0894 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009390 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009390 GO_component GO:0031237 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031237 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0009389 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009389 GO_function GO:0030151 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030151 GO_function GO:0048037 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048037 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0009061 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009061 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GeneID 945508 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945508 HOGENOM HOG000284390 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000284390&db=HOGENOM6 InParanoid P18775 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P18775 IntAct P18775 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P18775* IntEnz 1.8.5.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.8.5.3 InterPro IPR006311 http://www.ebi.ac.uk/interpro/entry/IPR006311 InterPro IPR006655 http://www.ebi.ac.uk/interpro/entry/IPR006655 InterPro IPR006656 http://www.ebi.ac.uk/interpro/entry/IPR006656 InterPro IPR006657 http://www.ebi.ac.uk/interpro/entry/IPR006657 InterPro IPR006963 http://www.ebi.ac.uk/interpro/entry/IPR006963 InterPro IPR009010 http://www.ebi.ac.uk/interpro/entry/IPR009010 InterPro IPR011888 http://www.ebi.ac.uk/interpro/entry/IPR011888 InterPro IPR019546 http://www.ebi.ac.uk/interpro/entry/IPR019546 InterPro IPR027467 http://www.ebi.ac.uk/interpro/entry/IPR027467 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5118 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5118 KEGG_Gene eco:b0894 http://www.genome.jp/dbget-bin/www_bget?eco:b0894 KEGG_Orthology KO:K07306 http://www.genome.jp/dbget-bin/www_bget?KO:K07306 MINT MINT-8046334 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8046334 OMA FRQQGIF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FRQQGIF PROSITE PS00490 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00490 PROSITE PS00551 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00551 PROSITE PS00932 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00932 PROSITE PS51318 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51318 PROSITE PS51669 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51669 PSORT swissprot:DMSA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DMSA_ECOLI PSORT-B swissprot:DMSA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DMSA_ECOLI PSORT2 swissprot:DMSA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DMSA_ECOLI Pfam PF00384 http://pfam.xfam.org/family/PF00384 Pfam PF01568 http://pfam.xfam.org/family/PF01568 Pfam PF04879 http://pfam.xfam.org/family/PF04879 Phobius swissprot:DMSA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DMSA_ECOLI PhylomeDB P18775 http://phylomedb.org/?seqid=P18775 ProteinModelPortal P18775 http://www.proteinmodelportal.org/query/uniprot/P18775 PubMed 10224050 http://www.ncbi.nlm.nih.gov/pubmed/10224050 PubMed 10801884 http://www.ncbi.nlm.nih.gov/pubmed/10801884 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17218314 http://www.ncbi.nlm.nih.gov/pubmed/17218314 PubMed 20169075 http://www.ncbi.nlm.nih.gov/pubmed/20169075 PubMed 2170332 http://www.ncbi.nlm.nih.gov/pubmed/2170332 PubMed 3062312 http://www.ncbi.nlm.nih.gov/pubmed/3062312 PubMed 3280546 http://www.ncbi.nlm.nih.gov/pubmed/3280546 PubMed 7721698 http://www.ncbi.nlm.nih.gov/pubmed/7721698 PubMed 8125918 http://www.ncbi.nlm.nih.gov/pubmed/8125918 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 8969520 http://www.ncbi.nlm.nih.gov/pubmed/8969520 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415414 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415414 RefSeq WP_000850303 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000850303 SMART SM00926 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00926 SMR P18775 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P18775 STRING 511145.b0894 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0894&targetmode=cogs STRING COG0243 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0243&targetmode=cogs SUPFAM SSF50692 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50692 TCDB 5.A.3.3 http://www.tcdb.org/search/result.php?tc=5.A.3.3 TIGRFAMs TIGR01409 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01409 TIGRFAMs TIGR02166 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02166 UniProtKB DMSA_ECOLI http://www.uniprot.org/uniprot/DMSA_ECOLI UniProtKB-AC P18775 http://www.uniprot.org/uniprot/P18775 charge swissprot:DMSA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DMSA_ECOLI eggNOG COG0243 http://eggnogapi.embl.de/nog_data/html/tree/COG0243 eggNOG ENOG4107QY8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QY8 epestfind swissprot:DMSA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DMSA_ECOLI garnier swissprot:DMSA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DMSA_ECOLI helixturnhelix swissprot:DMSA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DMSA_ECOLI hmoment swissprot:DMSA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DMSA_ECOLI iep swissprot:DMSA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DMSA_ECOLI inforesidue swissprot:DMSA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DMSA_ECOLI octanol swissprot:DMSA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DMSA_ECOLI pepcoil swissprot:DMSA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DMSA_ECOLI pepdigest swissprot:DMSA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DMSA_ECOLI pepinfo swissprot:DMSA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DMSA_ECOLI pepnet swissprot:DMSA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DMSA_ECOLI pepstats swissprot:DMSA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DMSA_ECOLI pepwheel swissprot:DMSA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DMSA_ECOLI pepwindow swissprot:DMSA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DMSA_ECOLI sigcleave swissprot:DMSA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DMSA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262325 19 # EcoGene EG13061 ygfK # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0005506 iron ion binding; IDA:EcoCyc. # GO_function GO:0016491 oxidoreductase activity; TAS:EcoCyc. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # Gene3D 3.20.20.70 -; 3. # Gene3D 3.50.50.60 -; 3. # IntAct Q46811 2 # InterPro IPR009051 Helical_ferredxn # InterPro IPR013785 Aldolase_TIM # InterPro IPR017701 Se_rdtase_YgfK # InterPro IPR017896 4Fe4S_Fe-S-bd # InterPro IPR017900 4Fe4S_Fe_S_CS # InterPro IPR023753 FAD/NAD-binding_dom # InterPro IPR028261 DPD_II # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00450 Selenocompound metabolism # Organism YGFK_ECOLI Escherichia coli (strain K12) # PATRIC 32121166 VBIEscCol129921_2971 # PIR F65071 F65071 # PROSITE PS00198 4FE4S_FER_1 # PROSITE PS51379 4FE4S_FER_2 # Pfam PF07992 Pyr_redox_2 # Pfam PF14691 Fer4_20 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGFK_ECOLI Uncharacterized protein YgfK # RefSeq NP_417354 NC_000913.3 # RefSeq WP_000502395 NZ_LN832404.1 # SIMILARITY Contains 1 4Fe-4S ferredoxin-type domain. {ECO:0000255|PROSITE-ProRule PRU00711}. # SUPFAM SSF46548 SSF46548; 2 # TIGRFAMs TIGR03315 Se_ygfK # eggNOG COG0493 LUCA # eggNOG ENOG4105BZ8 Bacteria BLAST swissprot:YGFK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGFK_ECOLI BioCyc ECOL316407:JW5923-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5923-MONOMER BioCyc EcoCyc:G7497-MONOMER http://biocyc.org/getid?id=EcoCyc:G7497-MONOMER DIP DIP-28091N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-28091N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 EchoBASE EB2873 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2873 EcoGene EG13061 http://www.ecogene.org/geneInfo.php?eg_id=EG13061 EnsemblBacteria AAC75916 http://www.ensemblgenomes.org/id/AAC75916 EnsemblBacteria AAC75916 http://www.ensemblgenomes.org/id/AAC75916 EnsemblBacteria BAE76944 http://www.ensemblgenomes.org/id/BAE76944 EnsemblBacteria BAE76944 http://www.ensemblgenomes.org/id/BAE76944 EnsemblBacteria BAE76944 http://www.ensemblgenomes.org/id/BAE76944 EnsemblBacteria b2878 http://www.ensemblgenomes.org/id/b2878 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 GeneID 949068 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949068 HOGENOM HOG000277437 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000277437&db=HOGENOM6 IntAct Q46811 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46811* InterPro IPR009051 http://www.ebi.ac.uk/interpro/entry/IPR009051 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR017701 http://www.ebi.ac.uk/interpro/entry/IPR017701 InterPro IPR017896 http://www.ebi.ac.uk/interpro/entry/IPR017896 InterPro IPR017900 http://www.ebi.ac.uk/interpro/entry/IPR017900 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 InterPro IPR028261 http://www.ebi.ac.uk/interpro/entry/IPR028261 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5923 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5923 KEGG_Gene eco:b2878 http://www.genome.jp/dbget-bin/www_bget?eco:b2878 KEGG_Orthology KO:K12527 http://www.genome.jp/dbget-bin/www_bget?KO:K12527 KEGG_Pathway ko00450 http://www.genome.jp/kegg-bin/show_pathway?ko00450 OMA EVCPNRA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EVCPNRA PROSITE PS00198 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00198 PROSITE PS51379 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51379 PSORT swissprot:YGFK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGFK_ECOLI PSORT-B swissprot:YGFK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGFK_ECOLI PSORT2 swissprot:YGFK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGFK_ECOLI Pfam PF07992 http://pfam.xfam.org/family/PF07992 Pfam PF14691 http://pfam.xfam.org/family/PF14691 Phobius swissprot:YGFK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGFK_ECOLI ProteinModelPortal Q46811 http://www.proteinmodelportal.org/query/uniprot/Q46811 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417354 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417354 RefSeq WP_000502395 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000502395 SMR Q46811 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46811 STRING 511145.b2878 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2878&targetmode=cogs SUPFAM SSF46548 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46548 TIGRFAMs TIGR03315 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03315 UniProtKB YGFK_ECOLI http://www.uniprot.org/uniprot/YGFK_ECOLI UniProtKB-AC Q46811 http://www.uniprot.org/uniprot/Q46811 charge swissprot:YGFK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGFK_ECOLI eggNOG COG0493 http://eggnogapi.embl.de/nog_data/html/tree/COG0493 eggNOG ENOG4105BZ8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZ8 epestfind swissprot:YGFK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGFK_ECOLI garnier swissprot:YGFK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGFK_ECOLI helixturnhelix swissprot:YGFK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGFK_ECOLI hmoment swissprot:YGFK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGFK_ECOLI iep swissprot:YGFK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGFK_ECOLI inforesidue swissprot:YGFK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGFK_ECOLI octanol swissprot:YGFK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGFK_ECOLI pepcoil swissprot:YGFK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGFK_ECOLI pepdigest swissprot:YGFK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGFK_ECOLI pepinfo swissprot:YGFK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGFK_ECOLI pepnet swissprot:YGFK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGFK_ECOLI pepstats swissprot:YGFK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGFK_ECOLI pepwheel swissprot:YGFK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGFK_ECOLI pepwindow swissprot:YGFK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGFK_ECOLI sigcleave swissprot:YGFK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGFK_ECOLI ## Database ID URL or Descriptions # AltName FIU_ECOLI Ferric iron uptake protein # AltName FIU_ECOLI TonB-dependent receptor Fiu # BioGrid 4259972 121 # EcoGene EG13317 fiu # FUNCTION FIU_ECOLI Involved in the active transport across the outer membrane of iron complexed with catecholate siderophores such as dihydroxybenzoylserine and dihydroxybenzoate. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB. Can also transport catechol-substituted cephalosporins. Receptor for microcins M, H47 and E492. {ECO 0000269|PubMed 12949180, ECO 0000269|PubMed 16718603, ECO 0000269|PubMed 2139424, ECO 0000269|PubMed 2407721, ECO 0000269|PubMed 3072926}. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0004872 receptor activity; IEA:InterPro. # GO_function GO:0005506 iron ion binding; IEA:InterPro. # GO_function GO:0015344 siderophore uptake transmembrane transporter activity; IBA:GO_Central. # GO_process GO:0015891 siderophore transport; IMP:EcoliWiki. # GO_process GO:0042884 microcin transport; IMP:EcoliWiki. # GO_process GO:0055072 iron ion homeostasis; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # GOslim_process GO:0042592 homeostatic process # Gene3D 2.170.130.10 -; 1. # Gene3D 2.40.170.20 -; 1. # INDUCTION FIU_ECOLI Repressed by iron. {ECO 0000269|PubMed 10411720, ECO 0000269|PubMed 1804764, ECO 0000269|PubMed 3072926}. # IntAct P75780 3 # InterPro IPR000531 TonB-dep_rcpt_b-brl # InterPro IPR010105 TonB_sidphr_rcpt # InterPro IPR010916 TonB_box_CS # InterPro IPR012910 Plug_dom # InterPro IPR030148 Fiu # KEGG_Brite ko02000 Transporters # Organism FIU_ECOLI Escherichia coli (strain K12) # PANTHER PTHR32552:SF8 PTHR32552:SF8; 2 # PATRIC 32116813 VBIEscCol129921_0832 # PIR E64817 E64817 # PROSITE PS00430 TONB_DEPENDENT_REC_1 # Pfam PF00593 TonB_dep_Rec # Pfam PF07715 Plug # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FIU_ECOLI Catecholate siderophore receptor Fiu # RefSeq NP_415326 NC_000913.3 # RefSeq WP_000430057 NZ_LN832404.1 # SIMILARITY Belongs to the TonB-dependent receptor family. {ECO 0000305}. # SUBCELLULAR LOCATION FIU_ECOLI Cell outer membrane. # TCDB 1.B.14.1 the outer membrane receptor (omr) family # TIGRFAMs TIGR01783 TonB-siderophor # eggNOG COG4774 LUCA # eggNOG ENOG4108IU3 Bacteria BLAST swissprot:FIU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FIU_ECOLI BioCyc ECOL316407:JW0790-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0790-MONOMER BioCyc EcoCyc:G6414-MONOMER http://biocyc.org/getid?id=EcoCyc:G6414-MONOMER COG COG4774 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4774 DIP DIP-11432N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11432N DOI 10.1007/s10534-005-4452-9 http://dx.doi.org/10.1007/s10534-005-4452-9 DOI 10.1016/0378-1097(90)90158-M http://dx.doi.org/10.1016/0378-1097(90)90158-M DOI 10.1016/0378-1097(91)90376-L http://dx.doi.org/10.1016/0378-1097(91)90376-L DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1999.01423.x http://dx.doi.org/10.1046/j.1365-2958.1999.01423.x DOI 10.1046/j.1432-1327.2000.01296.x http://dx.doi.org/10.1046/j.1432-1327.2000.01296.x DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1099/mic.0.26396-0 http://dx.doi.org/10.1099/mic.0.26396-0 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AAC.32.12.1879 http://dx.doi.org/10.1128/AAC.32.12.1879 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3101 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3101 EcoGene EG13317 http://www.ecogene.org/geneInfo.php?eg_id=EG13317 EnsemblBacteria AAC73892 http://www.ensemblgenomes.org/id/AAC73892 EnsemblBacteria AAC73892 http://www.ensemblgenomes.org/id/AAC73892 EnsemblBacteria BAA35471 http://www.ensemblgenomes.org/id/BAA35471 EnsemblBacteria BAA35471 http://www.ensemblgenomes.org/id/BAA35471 EnsemblBacteria BAA35471 http://www.ensemblgenomes.org/id/BAA35471 EnsemblBacteria b0805 http://www.ensemblgenomes.org/id/b0805 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0004872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004872 GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0015344 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015344 GO_process GO:0015891 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015891 GO_process GO:0042884 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042884 GO_process GO:0055072 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055072 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 Gene3D 2.170.130.10 http://www.cathdb.info/version/latest/superfamily/2.170.130.10 Gene3D 2.40.170.20 http://www.cathdb.info/version/latest/superfamily/2.40.170.20 GeneID 946246 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946246 HOGENOM HOG000130432 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000130432&db=HOGENOM6 InParanoid P75780 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75780 IntAct P75780 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75780* InterPro IPR000531 http://www.ebi.ac.uk/interpro/entry/IPR000531 InterPro IPR010105 http://www.ebi.ac.uk/interpro/entry/IPR010105 InterPro IPR010916 http://www.ebi.ac.uk/interpro/entry/IPR010916 InterPro IPR012910 http://www.ebi.ac.uk/interpro/entry/IPR012910 InterPro IPR030148 http://www.ebi.ac.uk/interpro/entry/IPR030148 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0790 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0790 KEGG_Gene eco:b0805 http://www.genome.jp/dbget-bin/www_bget?eco:b0805 KEGG_Orthology KO:K16090 http://www.genome.jp/dbget-bin/www_bget?KO:K16090 OMA QQVIKDT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QQVIKDT PANTHER PTHR32552:SF8 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32552:SF8 PROSITE PS00430 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00430 PSORT swissprot:FIU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FIU_ECOLI PSORT-B swissprot:FIU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FIU_ECOLI PSORT2 swissprot:FIU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FIU_ECOLI Pfam PF00593 http://pfam.xfam.org/family/PF00593 Pfam PF07715 http://pfam.xfam.org/family/PF07715 Phobius swissprot:FIU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FIU_ECOLI PhylomeDB P75780 http://phylomedb.org/?seqid=P75780 ProteinModelPortal P75780 http://www.proteinmodelportal.org/query/uniprot/P75780 PubMed 10411720 http://www.ncbi.nlm.nih.gov/pubmed/10411720 PubMed 10806384 http://www.ncbi.nlm.nih.gov/pubmed/10806384 PubMed 12949180 http://www.ncbi.nlm.nih.gov/pubmed/12949180 PubMed 16718603 http://www.ncbi.nlm.nih.gov/pubmed/16718603 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1804764 http://www.ncbi.nlm.nih.gov/pubmed/1804764 PubMed 2139424 http://www.ncbi.nlm.nih.gov/pubmed/2139424 PubMed 2407721 http://www.ncbi.nlm.nih.gov/pubmed/2407721 PubMed 3072926 http://www.ncbi.nlm.nih.gov/pubmed/3072926 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415326 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415326 RefSeq WP_000430057 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000430057 STRING 511145.b0805 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0805&targetmode=cogs STRING COG4774 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4774&targetmode=cogs TCDB 1.B.14.1 http://www.tcdb.org/search/result.php?tc=1.B.14.1 TIGRFAMs TIGR01783 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01783 UniProtKB FIU_ECOLI http://www.uniprot.org/uniprot/FIU_ECOLI UniProtKB-AC P75780 http://www.uniprot.org/uniprot/P75780 charge swissprot:FIU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FIU_ECOLI eggNOG COG4774 http://eggnogapi.embl.de/nog_data/html/tree/COG4774 eggNOG ENOG4108IU3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108IU3 epestfind swissprot:FIU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FIU_ECOLI garnier swissprot:FIU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FIU_ECOLI helixturnhelix swissprot:FIU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FIU_ECOLI hmoment swissprot:FIU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FIU_ECOLI iep swissprot:FIU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FIU_ECOLI inforesidue swissprot:FIU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FIU_ECOLI octanol swissprot:FIU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FIU_ECOLI pepcoil swissprot:FIU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FIU_ECOLI pepdigest swissprot:FIU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FIU_ECOLI pepinfo swissprot:FIU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FIU_ECOLI pepnet swissprot:FIU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FIU_ECOLI pepstats swissprot:FIU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FIU_ECOLI pepwheel swissprot:FIU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FIU_ECOLI pepwindow swissprot:FIU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FIU_ECOLI sigcleave swissprot:FIU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FIU_ECOLI ## Database ID URL or Descriptions # FUNCTION TRAY1_ECOLI Conjugative DNA transfer (CDT) is the unidirectional transfer of ssDNA plasmid from a donor to a recipient cell. It is the central mechanism by which antibiotic resistance and virulence factors are propagated in bacterial populations. Part of the relaxosome, which facilitates a site- and strand-specific cut in the origin of transfer by TraI, at the nic site. Relaxosome formation requires binding of IHF and TraY to the oriT region, which then faciliates binding of TraI. Upon binding to the oriT region TraY bends DNA 50 to 55 degrees. Also positively regulates tra gene expression. {ECO 0000269|PubMed 17238924, ECO 0000269|PubMed 7499339, ECO 0000269|PubMed 8152370, ECO 0000269|PubMed 8824627}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0000746 conjugation; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # InterPro IPR008876 TraY # Organism TRAY1_ECOLI Escherichia coli (strain K12) # PIR B21874 BVECTY # Pfam PF05509 TraY; 2 # RecName TRAY1_ECOLI Relaxosome protein TraY # RefSeq NP_061452 NC_002483.1 # RefSeq NP_862918 NC_004998.1 # RefSeq WP_001309237 NZ_CP014273.1 # RefSeq YP_009068352 NC_025139.1 # RefSeq YP_009070617 NC_025175.1 # SIMILARITY Belongs to the TraY family. {ECO 0000305}. # SUBCELLULAR LOCATION TRAY1_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT TRAY1_ECOLI Part of the relaxosome, a complex composed of plasmid encoded TraI, TraM, TraY and host-encoded IHF bound to the F plasmid origin of transfer (oriT). Interacts with TraM, probably through its C-terminus. {ECO 0000269|PubMed 17238924, ECO 0000269|PubMed 8152370}. BLAST swissprot:TRAY1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRAY1_ECOLI DOI 10.1016/0378-1119(83)90038-0 http://dx.doi.org/10.1016/0378-1119(83)90038-0 DOI 10.1074/jbc.270.47.28374 http://dx.doi.org/10.1074/jbc.270.47.28374 DOI 10.1074/jbc.270.47.28381 http://dx.doi.org/10.1074/jbc.270.47.28381 DOI 10.1111/j.1365-2958.1994.tb00327.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb00327.x DOI 10.1111/j.1365-2958.2006.05576.x http://dx.doi.org/10.1111/j.1365-2958.2006.05576.x EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL K01147 http://www.ebi.ac.uk/ena/data/view/K01147 EMBL U01159 http://www.ebi.ac.uk/ena/data/view/U01159 EMBL U50662 http://www.ebi.ac.uk/ena/data/view/U50662 EMBL U50663 http://www.ebi.ac.uk/ena/data/view/U50663 EMBL U50664 http://www.ebi.ac.uk/ena/data/view/U50664 EMBL U50666 http://www.ebi.ac.uk/ena/data/view/U50666 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0000746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000746 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 1263531 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263531 GeneID 1446482 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1446482 GeneID 20491482 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20491482 GeneID 20492685 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20492685 InterPro IPR008876 http://www.ebi.ac.uk/interpro/entry/IPR008876 OMA NRSKSHE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NRSKSHE PSORT swissprot:TRAY1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRAY1_ECOLI PSORT-B swissprot:TRAY1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRAY1_ECOLI PSORT2 swissprot:TRAY1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRAY1_ECOLI Pfam PF05509 http://pfam.xfam.org/family/PF05509 Phobius swissprot:TRAY1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRAY1_ECOLI ProteinModelPortal P06627 http://www.proteinmodelportal.org/query/uniprot/P06627 PubMed 17238924 http://www.ncbi.nlm.nih.gov/pubmed/17238924 PubMed 6368316 http://www.ncbi.nlm.nih.gov/pubmed/6368316 PubMed 7499339 http://www.ncbi.nlm.nih.gov/pubmed/7499339 PubMed 7499340 http://www.ncbi.nlm.nih.gov/pubmed/7499340 PubMed 7915817 http://www.ncbi.nlm.nih.gov/pubmed/7915817 PubMed 8152370 http://www.ncbi.nlm.nih.gov/pubmed/8152370 PubMed 8807284 http://www.ncbi.nlm.nih.gov/pubmed/8807284 PubMed 8824627 http://www.ncbi.nlm.nih.gov/pubmed/8824627 RefSeq NP_061452 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061452 RefSeq NP_862918 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_862918 RefSeq WP_001309237 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001309237 RefSeq YP_009068352 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009068352 RefSeq YP_009070617 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009070617 UniProtKB TRAY1_ECOLI http://www.uniprot.org/uniprot/TRAY1_ECOLI UniProtKB-AC P06627 http://www.uniprot.org/uniprot/P06627 charge swissprot:TRAY1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRAY1_ECOLI epestfind swissprot:TRAY1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRAY1_ECOLI garnier swissprot:TRAY1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRAY1_ECOLI helixturnhelix swissprot:TRAY1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRAY1_ECOLI hmoment swissprot:TRAY1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRAY1_ECOLI iep swissprot:TRAY1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRAY1_ECOLI inforesidue swissprot:TRAY1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRAY1_ECOLI octanol swissprot:TRAY1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRAY1_ECOLI pepcoil swissprot:TRAY1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRAY1_ECOLI pepdigest swissprot:TRAY1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRAY1_ECOLI pepinfo swissprot:TRAY1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRAY1_ECOLI pepnet swissprot:TRAY1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRAY1_ECOLI pepstats swissprot:TRAY1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRAY1_ECOLI pepwheel swissprot:TRAY1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRAY1_ECOLI pepwindow swissprot:TRAY1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRAY1_ECOLI sigcleave swissprot:TRAY1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRAY1_ECOLI ## Database ID URL or Descriptions # BioGrid 4262744 109 # EcoGene EG12558 yjhP # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0008757 S-adenosylmethionine-dependent methyltransferase activity; IBA:GO_Central. # GO_process GO:0032259 methylation; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.150 -; 1. # IntAct P39367 3 # InterPro IPR017031 Pre_MeTrfase_YjhP # InterPro IPR025714 Methyltranfer_dom # InterPro IPR029063 SAM-dependent_MTases # Organism YJHP_ECOLI Escherichia coli (strain K12) # PATRIC 32124200 VBIEscCol129921_4443 # PDB 1NKV X-ray; 2.90 A; A/B/C=1-248 # PIR S56531 S56531 # PIRSF PIRSF034653 Mtase_yjhp_prd # Pfam PF13847 Methyltransf_31 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJHP_ECOLI Uncharacterized protein YjhP # RefSeq NP_418726 NC_000913.3 # RefSeq WP_000354251 NZ_LN832404.1 # SUBCELLULAR LOCATION YJHP_ECOLI Membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. # SUPFAM SSF53335 SSF53335 # eggNOG ENOG4105DTA Bacteria # eggNOG ENOG410XQ9J LUCA BLAST swissprot:YJHP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJHP_ECOLI BioCyc ECOL316407:JW4268-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4268-MONOMER BioCyc EcoCyc:G7916-MONOMER http://biocyc.org/getid?id=EcoCyc:G7916-MONOMER DIP DIP-12624N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12624N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2446 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2446 EcoGene EG12558 http://www.ecogene.org/geneInfo.php?eg_id=EG12558 EnsemblBacteria AAC77262 http://www.ensemblgenomes.org/id/AAC77262 EnsemblBacteria AAC77262 http://www.ensemblgenomes.org/id/AAC77262 EnsemblBacteria BAE78298 http://www.ensemblgenomes.org/id/BAE78298 EnsemblBacteria BAE78298 http://www.ensemblgenomes.org/id/BAE78298 EnsemblBacteria BAE78298 http://www.ensemblgenomes.org/id/BAE78298 EnsemblBacteria b4306 http://www.ensemblgenomes.org/id/b4306 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008757 GO_process GO:0032259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032259 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 GeneID 946851 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946851 HOGENOM HOG000015884 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000015884&db=HOGENOM6 InParanoid P39367 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39367 IntAct P39367 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39367* InterPro IPR017031 http://www.ebi.ac.uk/interpro/entry/IPR017031 InterPro IPR025714 http://www.ebi.ac.uk/interpro/entry/IPR025714 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 KEGG_Gene ecj:JW4268 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4268 KEGG_Gene eco:b4306 http://www.genome.jp/dbget-bin/www_bget?eco:b4306 OMA ESAHRIH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ESAHRIH PDB 1NKV http://www.ebi.ac.uk/pdbe-srv/view/entry/1NKV PDBsum 1NKV http://www.ebi.ac.uk/pdbsum/1NKV PSORT swissprot:YJHP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJHP_ECOLI PSORT-B swissprot:YJHP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJHP_ECOLI PSORT2 swissprot:YJHP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJHP_ECOLI Pfam PF13847 http://pfam.xfam.org/family/PF13847 Phobius swissprot:YJHP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJHP_ECOLI PhylomeDB P39367 http://phylomedb.org/?seqid=P39367 ProteinModelPortal P39367 http://www.proteinmodelportal.org/query/uniprot/P39367 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418726 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418726 RefSeq WP_000354251 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000354251 SMR P39367 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39367 STRING 511145.b4306 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4306&targetmode=cogs SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 UniProtKB YJHP_ECOLI http://www.uniprot.org/uniprot/YJHP_ECOLI UniProtKB-AC P39367 http://www.uniprot.org/uniprot/P39367 charge swissprot:YJHP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJHP_ECOLI eggNOG ENOG4105DTA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DTA eggNOG ENOG410XQ9J http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQ9J epestfind swissprot:YJHP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJHP_ECOLI garnier swissprot:YJHP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJHP_ECOLI helixturnhelix swissprot:YJHP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJHP_ECOLI hmoment swissprot:YJHP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJHP_ECOLI iep swissprot:YJHP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJHP_ECOLI inforesidue swissprot:YJHP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJHP_ECOLI octanol swissprot:YJHP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJHP_ECOLI pepcoil swissprot:YJHP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJHP_ECOLI pepdigest swissprot:YJHP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJHP_ECOLI pepinfo swissprot:YJHP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJHP_ECOLI pepnet swissprot:YJHP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJHP_ECOLI pepstats swissprot:YJHP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJHP_ECOLI pepwheel swissprot:YJHP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJHP_ECOLI pepwindow swissprot:YJHP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJHP_ECOLI sigcleave swissprot:YJHP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJHP_ECOLI ## Database ID URL or Descriptions # AltName INSA7_ECOLI IS1f # EcoGene EG40001 insA7 # FUNCTION INSA7_ECOLI Absolutely required for transposition of IS1. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # InterPro IPR003220 InsA_N_dom # InterPro IPR024431 InsA_HTH_dom # Organism INSA7_ECOLI Escherichia coli (strain K12) # PATRIC 32124167 VBIEscCol129921_4427 # PIR E90800 E90800 # PIR JN0140 JN0140 # Pfam PF03811 Zn_Tnp_IS1 # Pfam PF12759 HTH_Tnp_IS1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSA7_ECOLI Insertion element IS1 7 protein InsA # RefSeq NP_418714 NC_000913.3 # SIMILARITY Belongs to the IS1 elements InsA family. {ECO 0000305}. # eggNOG COG3677 LUCA BLAST swissprot:INSA7_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSA7_ECOLI BioCyc ECOL316407:JW4254-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4254-MONOMER BioCyc EcoCyc:G7908-MONOMER http://biocyc.org/getid?id=EcoCyc:G7908-MONOMER DOI 10.1016/0378-1119(91)90096-T http://dx.doi.org/10.1016/0378-1119(91)90096-T DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X52538 http://www.ebi.ac.uk/ena/data/view/X52538 EchoBASE EB4743 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4743 EcoGene EG40001 http://www.ecogene.org/geneInfo.php?eg_id=EG40001 EnsemblBacteria AAC77250 http://www.ensemblgenomes.org/id/AAC77250 EnsemblBacteria AAC77250 http://www.ensemblgenomes.org/id/AAC77250 EnsemblBacteria BAE78285 http://www.ensemblgenomes.org/id/BAE78285 EnsemblBacteria BAE78285 http://www.ensemblgenomes.org/id/BAE78285 EnsemblBacteria BAE78285 http://www.ensemblgenomes.org/id/BAE78285 EnsemblBacteria b4294 http://www.ensemblgenomes.org/id/b4294 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GeneID 948830 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948830 HOGENOM HOG000007613 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000007613&db=HOGENOM6 InParanoid P19767 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P19767 IntAct P19767 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P19767* InterPro IPR003220 http://www.ebi.ac.uk/interpro/entry/IPR003220 InterPro IPR024431 http://www.ebi.ac.uk/interpro/entry/IPR024431 KEGG_Gene ecj:JW4254 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4254 KEGG_Gene eco:b4294 http://www.genome.jp/dbget-bin/www_bget?eco:b4294 OMA DMAMNGM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DMAMNGM PSORT swissprot:INSA7_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSA7_ECOLI PSORT-B swissprot:INSA7_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSA7_ECOLI PSORT2 swissprot:INSA7_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSA7_ECOLI Pfam PF03811 http://pfam.xfam.org/family/PF03811 Pfam PF12759 http://pfam.xfam.org/family/PF12759 Phobius swissprot:INSA7_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSA7_ECOLI PhylomeDB P19767 http://phylomedb.org/?seqid=P19767 ProteinModelPortal P19767 http://www.proteinmodelportal.org/query/uniprot/P19767 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1849492 http://www.ncbi.nlm.nih.gov/pubmed/1849492 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418714 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418714 STRING 511145.b4294 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4294&targetmode=cogs UniProtKB INSA7_ECOLI http://www.uniprot.org/uniprot/INSA7_ECOLI UniProtKB-AC P19767 http://www.uniprot.org/uniprot/P19767 charge swissprot:INSA7_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSA7_ECOLI eggNOG COG3677 http://eggnogapi.embl.de/nog_data/html/tree/COG3677 epestfind swissprot:INSA7_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSA7_ECOLI garnier swissprot:INSA7_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSA7_ECOLI helixturnhelix swissprot:INSA7_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSA7_ECOLI hmoment swissprot:INSA7_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSA7_ECOLI iep swissprot:INSA7_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSA7_ECOLI inforesidue swissprot:INSA7_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSA7_ECOLI octanol swissprot:INSA7_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSA7_ECOLI pepcoil swissprot:INSA7_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSA7_ECOLI pepdigest swissprot:INSA7_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSA7_ECOLI pepinfo swissprot:INSA7_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSA7_ECOLI pepnet swissprot:INSA7_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSA7_ECOLI pepstats swissprot:INSA7_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSA7_ECOLI pepwheel swissprot:INSA7_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSA7_ECOLI pepwindow swissprot:INSA7_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSA7_ECOLI sigcleave swissprot:INSA7_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSA7_ECOLI ## Database ID URL or Descriptions # AltName YHHA_ECOLI ORFQ # BioGrid 4261663 118 # EcoGene EG11184 yhhA # IntAct P0ADX7 3 # InterPro IPR020158 DUF2756 # Organism YHHA_ECOLI Escherichia coli (strain K12) # PATRIC 32122336 VBIEscCol129921_3545 # PIR S47667 S47667 # Pfam PF10956 DUF2756 # ProDom PD059127 Uncharacterised_YhhA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHHA_ECOLI Uncharacterized protein YhhA # RefSeq NP_417905 NC_000913.3 # RefSeq WP_000825996 NZ_LN832404.1 # eggNOG ENOG4105WC8 Bacteria # eggNOG ENOG411273Y LUCA BLAST swissprot:YHHA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHHA_ECOLI BioCyc ECOL316407:JW3413-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3413-MONOMER BioCyc EcoCyc:EG11184-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11184-MONOMER DIP DIP-47985N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47985N DOI 10.1007/BF00273621 http://dx.doi.org/10.1007/BF00273621 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X56908 http://www.ebi.ac.uk/ena/data/view/X56908 EchoBASE EB1171 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1171 EcoGene EG11184 http://www.ecogene.org/geneInfo.php?eg_id=EG11184 EnsemblBacteria AAC76473 http://www.ensemblgenomes.org/id/AAC76473 EnsemblBacteria AAC76473 http://www.ensemblgenomes.org/id/AAC76473 EnsemblBacteria BAE77845 http://www.ensemblgenomes.org/id/BAE77845 EnsemblBacteria BAE77845 http://www.ensemblgenomes.org/id/BAE77845 EnsemblBacteria BAE77845 http://www.ensemblgenomes.org/id/BAE77845 EnsemblBacteria b3448 http://www.ensemblgenomes.org/id/b3448 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947956 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947956 HOGENOM HOG000125675 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125675&db=HOGENOM6 IntAct P0ADX7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADX7* InterPro IPR020158 http://www.ebi.ac.uk/interpro/entry/IPR020158 KEGG_Gene ecj:JW3413 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3413 KEGG_Gene eco:b3448 http://www.genome.jp/dbget-bin/www_bget?eco:b3448 MINT MINT-1322710 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1322710 OMA AQPLNTM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AQPLNTM PSORT swissprot:YHHA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHHA_ECOLI PSORT-B swissprot:YHHA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHHA_ECOLI PSORT2 swissprot:YHHA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHHA_ECOLI Pfam PF10956 http://pfam.xfam.org/family/PF10956 Phobius swissprot:YHHA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHHA_ECOLI ProteinModelPortal P0ADX7 http://www.proteinmodelportal.org/query/uniprot/P0ADX7 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1851953 http://www.ncbi.nlm.nih.gov/pubmed/1851953 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417905 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417905 RefSeq WP_000825996 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000825996 STRING 511145.b3448 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3448&targetmode=cogs UniProtKB YHHA_ECOLI http://www.uniprot.org/uniprot/YHHA_ECOLI UniProtKB-AC P0ADX7 http://www.uniprot.org/uniprot/P0ADX7 charge swissprot:YHHA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHHA_ECOLI eggNOG ENOG4105WC8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105WC8 eggNOG ENOG411273Y http://eggnogapi.embl.de/nog_data/html/tree/ENOG411273Y epestfind swissprot:YHHA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHHA_ECOLI garnier swissprot:YHHA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHHA_ECOLI helixturnhelix swissprot:YHHA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHHA_ECOLI hmoment swissprot:YHHA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHHA_ECOLI iep swissprot:YHHA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHHA_ECOLI inforesidue swissprot:YHHA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHHA_ECOLI octanol swissprot:YHHA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHHA_ECOLI pepcoil swissprot:YHHA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHHA_ECOLI pepdigest swissprot:YHHA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHHA_ECOLI pepinfo swissprot:YHHA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHHA_ECOLI pepnet swissprot:YHHA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHHA_ECOLI pepstats swissprot:YHHA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHHA_ECOLI pepwheel swissprot:YHHA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHHA_ECOLI pepwindow swissprot:YHHA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHHA_ECOLI sigcleave swissprot:YHHA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHHA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261517 5 # EcoGene EG11338 msyB # FUNCTION MSYB_ECOLI Could participate in the normal pathway of protein export. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # IntAct P25738 9 # InterPro IPR025729 MsyB # Organism MSYB_ECOLI Escherichia coli (strain K12) # PATRIC 32117341 VBIEscCol129921_1093 # Pfam PF13984 MsyB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MSYB_ECOLI Acidic protein MsyB # RefSeq NP_415569 NC_000913.3 # RefSeq WP_000180056 NZ_LN832404.1 # eggNOG ENOG4108W47 Bacteria # eggNOG ENOG4111J86 LUCA BLAST swissprot:MSYB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MSYB_ECOLI BioCyc ECOL316407:JW1039-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1039-MONOMER BioCyc EcoCyc:EG11338-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11338-MONOMER DIP DIP-10265N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10265N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X59939 http://www.ebi.ac.uk/ena/data/view/X59939 EchoBASE EB1314 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1314 EcoGene EG11338 http://www.ecogene.org/geneInfo.php?eg_id=EG11338 EnsemblBacteria AAC74135 http://www.ensemblgenomes.org/id/AAC74135 EnsemblBacteria AAC74135 http://www.ensemblgenomes.org/id/AAC74135 EnsemblBacteria BAA35850 http://www.ensemblgenomes.org/id/BAA35850 EnsemblBacteria BAA35850 http://www.ensemblgenomes.org/id/BAA35850 EnsemblBacteria BAA35850 http://www.ensemblgenomes.org/id/BAA35850 EnsemblBacteria b1051 http://www.ensemblgenomes.org/id/b1051 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GeneID 945612 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945612 HOGENOM HOG000118996 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118996&db=HOGENOM6 IntAct P25738 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P25738* InterPro IPR025729 http://www.ebi.ac.uk/interpro/entry/IPR025729 KEGG_Gene ecj:JW1039 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1039 KEGG_Gene eco:b1051 http://www.genome.jp/dbget-bin/www_bget?eco:b1051 KEGG_Orthology KO:K12147 http://www.genome.jp/dbget-bin/www_bget?KO:K12147 OMA GDEGECL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GDEGECL PSORT swissprot:MSYB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MSYB_ECOLI PSORT-B swissprot:MSYB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MSYB_ECOLI PSORT2 swissprot:MSYB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MSYB_ECOLI Pfam PF13984 http://pfam.xfam.org/family/PF13984 Phobius swissprot:MSYB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MSYB_ECOLI ProteinModelPortal P25738 http://www.proteinmodelportal.org/query/uniprot/P25738 PubMed 1537791 http://www.ncbi.nlm.nih.gov/pubmed/1537791 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415569 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415569 RefSeq WP_000180056 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000180056 STRING 511145.b1051 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1051&targetmode=cogs UniProtKB MSYB_ECOLI http://www.uniprot.org/uniprot/MSYB_ECOLI UniProtKB-AC P25738 http://www.uniprot.org/uniprot/P25738 charge swissprot:MSYB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MSYB_ECOLI eggNOG ENOG4108W47 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108W47 eggNOG ENOG4111J86 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111J86 epestfind swissprot:MSYB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MSYB_ECOLI garnier swissprot:MSYB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MSYB_ECOLI helixturnhelix swissprot:MSYB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MSYB_ECOLI hmoment swissprot:MSYB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MSYB_ECOLI iep swissprot:MSYB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MSYB_ECOLI inforesidue swissprot:MSYB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MSYB_ECOLI octanol swissprot:MSYB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MSYB_ECOLI pepcoil swissprot:MSYB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MSYB_ECOLI pepdigest swissprot:MSYB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MSYB_ECOLI pepinfo swissprot:MSYB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MSYB_ECOLI pepnet swissprot:MSYB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MSYB_ECOLI pepstats swissprot:MSYB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MSYB_ECOLI pepwheel swissprot:MSYB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MSYB_ECOLI pepwindow swissprot:MSYB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MSYB_ECOLI sigcleave swissprot:MSYB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MSYB_ECOLI ## Database ID URL or Descriptions # BioGrid 4262829 8 # EcoGene EG13677 ybjH # Organism YBJH_ECOLI Escherichia coli (strain K12) # PATRIC 32116891 VBIEscCol129921_0871 # PIR C64822 C64822 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBJH_ECOLI Uncharacterized protein YbjH # RefSeq NP_415364 NC_000913.3 BLAST swissprot:YBJH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBJH_ECOLI BioCyc ECOL316407:JW0827-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0827-MONOMER BioCyc EcoCyc:G6441-MONOMER http://biocyc.org/getid?id=EcoCyc:G6441-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3441 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3441 EcoGene EG13677 http://www.ecogene.org/geneInfo.php?eg_id=EG13677 EnsemblBacteria AAC73930 http://www.ensemblgenomes.org/id/AAC73930 EnsemblBacteria AAC73930 http://www.ensemblgenomes.org/id/AAC73930 EnsemblBacteria BAA35547 http://www.ensemblgenomes.org/id/BAA35547 EnsemblBacteria BAA35547 http://www.ensemblgenomes.org/id/BAA35547 EnsemblBacteria BAA35547 http://www.ensemblgenomes.org/id/BAA35547 EnsemblBacteria b0843 http://www.ensemblgenomes.org/id/b0843 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945447 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945447 HOGENOM HOG000118216 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118216&db=HOGENOM6 KEGG_Gene ecj:JW0827 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0827 KEGG_Gene eco:b0843 http://www.genome.jp/dbget-bin/www_bget?eco:b0843 OMA VYHPRAR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VYHPRAR PSORT swissprot:YBJH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBJH_ECOLI PSORT-B swissprot:YBJH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBJH_ECOLI PSORT2 swissprot:YBJH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBJH_ECOLI Phobius swissprot:YBJH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBJH_ECOLI ProteinModelPortal P0AAY4 http://www.proteinmodelportal.org/query/uniprot/P0AAY4 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415364 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415364 STRING 511145.b0843 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0843&targetmode=cogs UniProtKB YBJH_ECOLI http://www.uniprot.org/uniprot/YBJH_ECOLI UniProtKB-AC P0AAY4 http://www.uniprot.org/uniprot/P0AAY4 charge swissprot:YBJH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBJH_ECOLI epestfind swissprot:YBJH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBJH_ECOLI garnier swissprot:YBJH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBJH_ECOLI helixturnhelix swissprot:YBJH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBJH_ECOLI hmoment swissprot:YBJH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBJH_ECOLI iep swissprot:YBJH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBJH_ECOLI inforesidue swissprot:YBJH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBJH_ECOLI octanol swissprot:YBJH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBJH_ECOLI pepcoil swissprot:YBJH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBJH_ECOLI pepdigest swissprot:YBJH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBJH_ECOLI pepinfo swissprot:YBJH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBJH_ECOLI pepnet swissprot:YBJH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBJH_ECOLI pepstats swissprot:YBJH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBJH_ECOLI pepwheel swissprot:YBJH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBJH_ECOLI pepwindow swissprot:YBJH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBJH_ECOLI sigcleave swissprot:YBJH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBJH_ECOLI ## Database ID URL or Descriptions # AltName AES_ECOLI EcE # BIOPHYSICOCHEMICAL PROPERTIES AES_ECOLI Kinetic parameters KM=1.5 mM for p-nitrophenylacetate (at pH 7.1 and 25 degrees Celsius) {ECO 0000269|PubMed 9576853}; KM=0.7 mM for p-nitrophenylpropionate (at pH 7.1 and 25 degrees Celsius) {ECO 0000269|PubMed 9576853}; KM=0.5 mM for p-nitrophenylbutyrate (at pH 7.1 and 25 degrees Celsius) {ECO 0000269|PubMed 9576853}; KM=0.26 mM for p-nitrophenylvalerate (at pH 7.1 and 25 degrees Celsius) {ECO 0000269|PubMed 9576853}; KM=0.22 mM for p-nitrophenylhexanoate (at pH 7.1 and 25 degrees Celsius) {ECO 0000269|PubMed 9576853}; KM=0.16 mM for p-nitrophenyloctanoate (at pH 7.1 and 25 degrees Celsius) {ECO 0000269|PubMed 9576853}; Vmax=34.2 umol/min/mg enzyme toward p-nitrophenylbutyrate (at pH 5.6 and 30 degrees Celsius) {ECO 0000269|PubMed 9576853}; Vmax=3.67 umol/min/mg enzyme toward tributyrylglycerol (at pH 5.6 and 30 degrees Celsius) {ECO 0000269|PubMed 9576853}; Vmax=0.22 umol/min/mg enzyme toward trioleylglycerol (at pH 5.6 and 30 degrees Celsius) {ECO 0000269|PubMed 9576853}; pH dependence Optimum pH is 9.0. {ECO 0000269|PubMed 9576853}; # BRENDA 3.1.1 2026 # BioGrid 4263164 3 # ESTHER ecoli-Aes Hormone-sensitive_lipase_like_1 # EcoGene EG11101 aes # FUNCTION AES_ECOLI Displays esterase activity towards short chain fatty esters (acyl chain length of up to 8 carbons). Able to hydrolyze triacetylglycerol (triacetin) and tributyrylglycerol (tributyrin), but not trioleylglycerol (triolein) or cholesterol oleate. Negatively regulates MalT activity by antagonizing maltotriose binding. Inhibits MelA galactosidase activity. {ECO 0000269|PubMed 11867639, ECO 0000269|PubMed 12374803, ECO 0000269|PubMed 9576853}. # GO_component GO:0005737 cytoplasm; NAS:EcoliWiki. # GO_function GO:0008126 acetylesterase activity; IDA:EcoCyc. # GO_function GO:0016787 hydrolase activity; IDA:EcoliWiki. # GO_function GO:0034338 short-chain carboxylesterase activity; IDA:EcoliWiki. # GO_process GO:0009056 catabolic process; IBA:GO_Central. # GO_process GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity; IDA:EcoCyc. # GO_process GO:0051346 negative regulation of hydrolase activity; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # Gene3D 3.40.50.1820 -; 1. # HAMAP MF_01958 Acetyl_esterase # IntAct P23872 8 # InterPro IPR002168 Lipase_GDXG_HIS_AS # InterPro IPR013094 AB_hydrolase_3 # InterPro IPR023508 Acetyl_esterase # InterPro IPR029058 AB_hydrolase # InterPro IPR033140 Lipase_GDXG_put_SER_AS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00363 Bisphenol degradation # KEGG_Pathway ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis # MISCELLANEOUS AES_ECOLI Not essential for cell growth. # Organism AES_ECOLI Escherichia coli (strain K12) # PATRIC 32116109 VBIEscCol129921_0496 # PDB 4KRX X-ray; 1.80 A; A/B/C=1-319 # PDB 4KRY X-ray; 2.30 A; A/B/C/D/E/F=1-319 # PIR C64778 C64778 # PROSITE PS01173 LIPASE_GDXG_HIS # PROSITE PS01174 LIPASE_GDXG_SER # Pfam PF07859 Abhydrolase_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AES_ECOLI Acetyl esterase # RefSeq NP_415009 NC_000913.3 # RefSeq WP_000801813 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=L35149; Type=Frameshift; Positions=37; Evidence={ECO 0000305}; # SIMILARITY Belongs to the 'GDXG' lipolytic enzyme family. {ECO 0000305}. # SUBCELLULAR LOCATION AES_ECOLI Cytoplasm {ECO 0000269|PubMed 9576853}. # SUBUNIT AES_ECOLI Homodimer. Interacts with MalT and MelA. {ECO 0000269|PubMed 11867639, ECO 0000269|PubMed 12374803}. # SUPFAM SSF53474 SSF53474 # eggNOG COG0657 LUCA # eggNOG ENOG4105F2M Bacteria BLAST swissprot:AES_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AES_ECOLI BioCyc ECOL316407:JW0465-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0465-MONOMER BioCyc EcoCyc:EG11101-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11101-MONOMER BioCyc MetaCyc:EG11101-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11101-MONOMER COG COG0657 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0657 DIP DIP-9062N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9062N DOI 10.1016/0022-2836(91)90180-E http://dx.doi.org/10.1016/0022-2836(91)90180-E DOI 10.1016/S0014-5793(99)00813-3 http://dx.doi.org/10.1016/S0014-5793(99)00813-3 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj3320075 http://dx.doi.org/10.1042/bj3320075 DOI 10.1074/jbc.M200991200 http://dx.doi.org/10.1074/jbc.M200991200 DOI 10.1074/jbc.M207398200 http://dx.doi.org/10.1074/jbc.M207398200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.1.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D00798 http://www.ebi.ac.uk/ena/data/view/D00798 EMBL D90259 http://www.ebi.ac.uk/ena/data/view/D90259 EMBL L35149 http://www.ebi.ac.uk/ena/data/view/L35149 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 ENZYME 3.1.1.- http://enzyme.expasy.org/EC/3.1.1.- EchoBASE EB1093 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1093 EcoGene EG11101 http://www.ecogene.org/geneInfo.php?eg_id=EG11101 EnsemblBacteria AAC73578 http://www.ensemblgenomes.org/id/AAC73578 EnsemblBacteria AAC73578 http://www.ensemblgenomes.org/id/AAC73578 EnsemblBacteria BAE76255 http://www.ensemblgenomes.org/id/BAE76255 EnsemblBacteria BAE76255 http://www.ensemblgenomes.org/id/BAE76255 EnsemblBacteria BAE76255 http://www.ensemblgenomes.org/id/BAE76255 EnsemblBacteria b0476 http://www.ensemblgenomes.org/id/b0476 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0008126 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008126 GO_function GO:0016787 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016787 GO_function GO:0034338 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034338 GO_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GO_process GO:0043433 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043433 GO_process GO:0051346 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051346 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 3.40.50.1820 http://www.cathdb.info/version/latest/superfamily/3.40.50.1820 GeneID 947514 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947514 HAMAP MF_01958 http://hamap.expasy.org/unirule/MF_01958 HOGENOM HOG000117644 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117644&db=HOGENOM6 InParanoid P23872 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23872 IntAct P23872 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P23872* IntEnz 3.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.1 InterPro IPR002168 http://www.ebi.ac.uk/interpro/entry/IPR002168 InterPro IPR013094 http://www.ebi.ac.uk/interpro/entry/IPR013094 InterPro IPR023508 http://www.ebi.ac.uk/interpro/entry/IPR023508 InterPro IPR029058 http://www.ebi.ac.uk/interpro/entry/IPR029058 InterPro IPR033140 http://www.ebi.ac.uk/interpro/entry/IPR033140 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0465 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0465 KEGG_Gene eco:b0476 http://www.genome.jp/dbget-bin/www_bget?eco:b0476 KEGG_Orthology KO:K01066 http://www.genome.jp/dbget-bin/www_bget?KO:K01066 KEGG_Pathway ko00363 http://www.genome.jp/kegg-bin/show_pathway?ko00363 KEGG_Pathway ko00960 http://www.genome.jp/kegg-bin/show_pathway?ko00960 KEGG_Reaction rn:R05420 http://www.genome.jp/dbget-bin/www_bget?rn:R05420 KEGG_Reaction rn:R06729 http://www.genome.jp/dbget-bin/www_bget?rn:R06729 KEGG_Reaction rn:R09105 http://www.genome.jp/dbget-bin/www_bget?rn:R09105 OMA RMMESAD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RMMESAD PDB 4KRX http://www.ebi.ac.uk/pdbe-srv/view/entry/4KRX PDB 4KRY http://www.ebi.ac.uk/pdbe-srv/view/entry/4KRY PDBsum 4KRX http://www.ebi.ac.uk/pdbsum/4KRX PDBsum 4KRY http://www.ebi.ac.uk/pdbsum/4KRY PROSITE PS01173 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01173 PROSITE PS01174 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01174 PSORT swissprot:AES_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AES_ECOLI PSORT-B swissprot:AES_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AES_ECOLI PSORT2 swissprot:AES_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AES_ECOLI Pfam PF07859 http://pfam.xfam.org/family/PF07859 Phobius swissprot:AES_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AES_ECOLI PhylomeDB P23872 http://phylomedb.org/?seqid=P23872 ProteinModelPortal P23872 http://www.proteinmodelportal.org/query/uniprot/P23872 PubMed 10431819 http://www.ncbi.nlm.nih.gov/pubmed/10431819 PubMed 11867639 http://www.ncbi.nlm.nih.gov/pubmed/11867639 PubMed 12374803 http://www.ncbi.nlm.nih.gov/pubmed/12374803 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2051480 http://www.ncbi.nlm.nih.gov/pubmed/2051480 PubMed 7721718 http://www.ncbi.nlm.nih.gov/pubmed/7721718 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9401025 http://www.ncbi.nlm.nih.gov/pubmed/9401025 PubMed 9576853 http://www.ncbi.nlm.nih.gov/pubmed/9576853 RefSeq NP_415009 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415009 RefSeq WP_000801813 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000801813 SMR P23872 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P23872 STRING 511145.b0476 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0476&targetmode=cogs STRING COG0657 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0657&targetmode=cogs SUPFAM SSF53474 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53474 UniProtKB AES_ECOLI http://www.uniprot.org/uniprot/AES_ECOLI UniProtKB-AC P23872 http://www.uniprot.org/uniprot/P23872 charge swissprot:AES_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AES_ECOLI eggNOG COG0657 http://eggnogapi.embl.de/nog_data/html/tree/COG0657 eggNOG ENOG4105F2M http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F2M epestfind swissprot:AES_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AES_ECOLI garnier swissprot:AES_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AES_ECOLI helixturnhelix swissprot:AES_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AES_ECOLI hmoment swissprot:AES_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AES_ECOLI iep swissprot:AES_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AES_ECOLI inforesidue swissprot:AES_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AES_ECOLI octanol swissprot:AES_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AES_ECOLI pepcoil swissprot:AES_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AES_ECOLI pepdigest swissprot:AES_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AES_ECOLI pepinfo swissprot:AES_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AES_ECOLI pepnet swissprot:AES_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AES_ECOLI pepstats swissprot:AES_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AES_ECOLI pepwheel swissprot:AES_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AES_ECOLI pepwindow swissprot:AES_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AES_ECOLI sigcleave swissprot:AES_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AES_ECOLI ## Database ID URL or Descriptions # EcoGene EG40012 insL3 # FUNCTION INSL3_ECOLI Involved in the transposition of the insertion sequence IS186. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 3.90.350.10 -; 1. # InterPro IPR002559 Transposase_11 # InterPro IPR012337 RNaseH-like_dom # InterPro IPR014736 Transposase_Tn5-like_core # Organism INSL3_ECOLI Escherichia coli (strain K12) # PIR G65013 QQEC47 # Pfam PF01609 DDE_Tnp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSL3_ECOLI Putative transposase InsL for insertion sequence element IS186C # RefSeq NP_414557 NC_000913.3 # RefSeq NP_415114 NC_000913.3 # RefSeq NP_416895 NC_000913.3 # RefSeq WP_001300563 NZ_LN832404.1 # SIMILARITY Belongs to the transposase 11 family. {ECO 0000305}. # SUPFAM SSF53098 SSF53098 # eggNOG COG3385 LUCA # eggNOG ENOG4108SER Bacteria BLAST swissprot:INSL3_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSL3_ECOLI BioCyc EcoCyc:G7255-MONOMER http://biocyc.org/getid?id=EcoCyc:G7255-MONOMER DIP DIP-28060N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-28060N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4758 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4758 EcoGene EG40012 http://www.ecogene.org/geneInfo.php?eg_id=EG40012 EnsemblBacteria AAC75453 http://www.ensemblgenomes.org/id/AAC75453 EnsemblBacteria AAC75453 http://www.ensemblgenomes.org/id/AAC75453 EnsemblBacteria BAA16264 http://www.ensemblgenomes.org/id/BAA16264 EnsemblBacteria BAA16264 http://www.ensemblgenomes.org/id/BAA16264 EnsemblBacteria BAA16264 http://www.ensemblgenomes.org/id/BAA16264 EnsemblBacteria b2394 http://www.ensemblgenomes.org/id/b2394 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 3.90.350.10 http://www.cathdb.info/version/latest/superfamily/3.90.350.10 GeneID 944754 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944754 GeneID 945200 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945200 GeneID 946896 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946896 InParanoid P0CF93 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CF93 InterPro IPR002559 http://www.ebi.ac.uk/interpro/entry/IPR002559 InterPro IPR012337 http://www.ebi.ac.uk/interpro/entry/IPR012337 InterPro IPR014736 http://www.ebi.ac.uk/interpro/entry/IPR014736 KEGG_Gene ecj:JW5390 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5390 KEGG_Gene eco:b0016 http://www.genome.jp/dbget-bin/www_bget?eco:b0016 KEGG_Gene eco:b0582 http://www.genome.jp/dbget-bin/www_bget?eco:b0582 KEGG_Gene eco:b2394 http://www.genome.jp/dbget-bin/www_bget?eco:b2394 PSORT swissprot:INSL3_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSL3_ECOLI PSORT-B swissprot:INSL3_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSL3_ECOLI PSORT2 swissprot:INSL3_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSL3_ECOLI Pfam PF01609 http://pfam.xfam.org/family/PF01609 Phobius swissprot:INSL3_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSL3_ECOLI ProteinModelPortal P0CF93 http://www.proteinmodelportal.org/query/uniprot/P0CF93 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414557 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414557 RefSeq NP_415114 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415114 RefSeq NP_416895 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416895 RefSeq WP_001300563 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300563 STRING 511145.b2394 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2394&targetmode=cogs SUPFAM SSF53098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098 UniProtKB INSL3_ECOLI http://www.uniprot.org/uniprot/INSL3_ECOLI UniProtKB-AC P0CF93 http://www.uniprot.org/uniprot/P0CF93 charge swissprot:INSL3_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSL3_ECOLI eggNOG COG3385 http://eggnogapi.embl.de/nog_data/html/tree/COG3385 eggNOG ENOG4108SER http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108SER epestfind swissprot:INSL3_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSL3_ECOLI garnier swissprot:INSL3_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSL3_ECOLI helixturnhelix swissprot:INSL3_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSL3_ECOLI hmoment swissprot:INSL3_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSL3_ECOLI iep swissprot:INSL3_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSL3_ECOLI inforesidue swissprot:INSL3_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSL3_ECOLI octanol swissprot:INSL3_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSL3_ECOLI pepcoil swissprot:INSL3_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSL3_ECOLI pepdigest swissprot:INSL3_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSL3_ECOLI pepinfo swissprot:INSL3_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSL3_ECOLI pepnet swissprot:INSL3_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSL3_ECOLI pepstats swissprot:INSL3_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSL3_ECOLI pepwheel swissprot:INSL3_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSL3_ECOLI pepwindow swissprot:INSL3_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSL3_ECOLI sigcleave swissprot:INSL3_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSL3_ECOLI ## Database ID URL or Descriptions # FUNCTION TRAH1_ECOLI Involved in pilus assembly. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_process GO:0000746 conjugation; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0008150 biological_process # InterPro IPR010927 T4SS_TraH # Organism TRAH1_ECOLI Escherichia coli (strain K12) # PIR S20479 BVECTH # Pfam PF06122 TraH # RecName TRAH1_ECOLI Protein TraH # RefSeq NP_061477 NC_002483.1 # RefSeq NP_862943 NC_004998.1 # RefSeq WP_000982831 NZ_CP014273.1 # RefSeq YP_009060136 NC_024956.1 # RefSeq YP_009068325 NC_025139.1 # RefSeq YP_009070590 NC_025175.1 # SUBCELLULAR LOCATION TRAH1_ECOLI Periplasm. BLAST swissprot:TRAH1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRAH1_ECOLI DIP DIP-28105N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-28105N DOI 10.1007/BF00299147 http://dx.doi.org/10.1007/BF00299147 DOI 10.1016/0378-1119(89)90392-2 http://dx.doi.org/10.1016/0378-1119(89)90392-2 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL M24492 http://www.ebi.ac.uk/ena/data/view/M24492 EMBL M59763 http://www.ebi.ac.uk/ena/data/view/M59763 EMBL U01159 http://www.ebi.ac.uk/ena/data/view/U01159 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_process GO:0000746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000746 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 1263523 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263523 GeneID 1446506 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1446506 GeneID 20467940 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20467940 GeneID 20491455 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20491455 GeneID 20492658 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20492658 InterPro IPR010927 http://www.ebi.ac.uk/interpro/entry/IPR010927 OMA CANTECT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CANTECT PSORT swissprot:TRAH1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRAH1_ECOLI PSORT-B swissprot:TRAH1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRAH1_ECOLI PSORT2 swissprot:TRAH1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRAH1_ECOLI Pfam PF06122 http://pfam.xfam.org/family/PF06122 Phobius swissprot:TRAH1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRAH1_ECOLI ProteinModelPortal P15069 http://www.proteinmodelportal.org/query/uniprot/P15069 PubMed 1348105 http://www.ncbi.nlm.nih.gov/pubmed/1348105 PubMed 2656408 http://www.ncbi.nlm.nih.gov/pubmed/2656408 PubMed 7915817 http://www.ncbi.nlm.nih.gov/pubmed/7915817 RefSeq NP_061477 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061477 RefSeq NP_862943 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_862943 RefSeq WP_000982831 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000982831 RefSeq YP_009060136 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009060136 RefSeq YP_009068325 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009068325 RefSeq YP_009070590 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009070590 SMR P15069 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P15069 UniProtKB TRAH1_ECOLI http://www.uniprot.org/uniprot/TRAH1_ECOLI UniProtKB-AC P15069 http://www.uniprot.org/uniprot/P15069 charge swissprot:TRAH1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRAH1_ECOLI epestfind swissprot:TRAH1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRAH1_ECOLI garnier swissprot:TRAH1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRAH1_ECOLI helixturnhelix swissprot:TRAH1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRAH1_ECOLI hmoment swissprot:TRAH1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRAH1_ECOLI iep swissprot:TRAH1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRAH1_ECOLI inforesidue swissprot:TRAH1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRAH1_ECOLI octanol swissprot:TRAH1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRAH1_ECOLI pepcoil swissprot:TRAH1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRAH1_ECOLI pepdigest swissprot:TRAH1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRAH1_ECOLI pepinfo swissprot:TRAH1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRAH1_ECOLI pepnet swissprot:TRAH1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRAH1_ECOLI pepstats swissprot:TRAH1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRAH1_ECOLI pepwheel swissprot:TRAH1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRAH1_ECOLI pepwindow swissprot:TRAH1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRAH1_ECOLI sigcleave swissprot:TRAH1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRAH1_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES pH dependence: Optimum pH is 6.5-7.0.; Temperature dependence Optimum temperature is 60 degrees Celsius.; # BioGrid 4262580 9 # CATALYTIC ACTIVITY ADEC_ECOLI Adenine + H(2)O = hypoxanthine + NH(3). {ECO 0000269|PubMed 11440125, ECO 0000269|PubMed 12077137}. # CDD cd01295 AdeC # COFACTOR ADEC_ECOLI Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 11440125, ECO 0000269|PubMed 12077137}; # EcoGene EG11692 ade # GO_function GO:0000034 adenine deaminase activity; IDA:EcoCyc. # GO_function GO:0004096 catalase activity; IDA:EcoCyc. # GO_function GO:0008198 ferrous iron binding; IDA:EcoCyc. # GO_function GO:0030145 manganese ion binding; IDA:EcoCyc. # GO_process GO:0006146 adenine catabolic process; IMP:EcoliWiki. # GO_process GO:0046101 hypoxanthine biosynthetic process; IMP:EcoliWiki. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 2.30.40.10 -; 1. # HAMAP MF_01518 Adenine_deamin # INDUCTION Repressed by H-NS. Activated by insertion of a variety of IS elements into a region extending from -145 to +13 relative to the transcription start site. IS elements essentially eliminate the H-NS-mediated silencing, but also stimulate ade expression 2-3 fold independently of the H-NS protein. {ECO:0000269|PubMed 12077137}. # IntAct P31441 11 # InterPro IPR006679 Adenine_deam # InterPro IPR006680 Amidohydro-rel # InterPro IPR011059 Metal-dep_hydrolase_composite # InterPro IPR026912 Adenine_deam_C # InterPro IPR032466 Metal_Hydrolase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # MISCELLANEOUS ADEC_ECOLI Ade is a cryptic gene in wild-type strains. The physiological conditions that lead to its activation are unknown. # Organism ADEC_ECOLI Escherichia coli (strain K12) # PATRIC 32122823 VBIEscCol129921_3787 # PIR B65168 B65168 # Pfam PF01979 Amidohydro_1 # Pfam PF13382 Adenine_deam_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ADEC_ECOLI Adenine deaminase # RefSeq NP_418121 NC_000913.3 # RefSeq WP_001065718 NZ_LN832404.1 # SIMILARITY Belongs to the adenine deaminase family. {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 11440125}. # SUPFAM SSF51338 SSF51338; 2 # SUPFAM SSF51556 SSF51556 # TIGRFAMs TIGR01178 ade # eggNOG COG1001 LUCA # eggNOG ENOG4105CPN Bacteria BLAST swissprot:ADEC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ADEC_ECOLI BioCyc ECOL316407:JW3640-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3640-MONOMER BioCyc EcoCyc:EG11692-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11692-MONOMER BioCyc MetaCyc:EG11692-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11692-MONOMER COG COG1001 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1001 DIP DIP-12439N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12439N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M204268200 http://dx.doi.org/10.1074/jbc.M204268200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1271/bbb.65.1112 http://dx.doi.org/10.1271/bbb.65.1112 EC_number EC:3.5.4.2 http://www.genome.jp/dbget-bin/www_bget?EC:3.5.4.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.5.4.2 http://enzyme.expasy.org/EC/3.5.4.2 EchoBASE EB1643 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1643 EcoGene EG11692 http://www.ecogene.org/geneInfo.php?eg_id=EG11692 EnsemblBacteria AAC76688 http://www.ensemblgenomes.org/id/AAC76688 EnsemblBacteria AAC76688 http://www.ensemblgenomes.org/id/AAC76688 EnsemblBacteria BAE77628 http://www.ensemblgenomes.org/id/BAE77628 EnsemblBacteria BAE77628 http://www.ensemblgenomes.org/id/BAE77628 EnsemblBacteria BAE77628 http://www.ensemblgenomes.org/id/BAE77628 EnsemblBacteria b3665 http://www.ensemblgenomes.org/id/b3665 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000034 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000034 GO_function GO:0004096 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004096 GO_function GO:0008198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008198 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_process GO:0006146 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006146 GO_process GO:0046101 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046101 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 2.30.40.10 http://www.cathdb.info/version/latest/superfamily/2.30.40.10 GeneID 948210 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948210 HAMAP MF_01518 http://hamap.expasy.org/unirule/MF_01518 HOGENOM HOG000276949 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276949&db=HOGENOM6 InParanoid P31441 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31441 IntAct P31441 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31441* IntEnz 3.5.4.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.4.2 InterPro IPR006679 http://www.ebi.ac.uk/interpro/entry/IPR006679 InterPro IPR006680 http://www.ebi.ac.uk/interpro/entry/IPR006680 InterPro IPR011059 http://www.ebi.ac.uk/interpro/entry/IPR011059 InterPro IPR026912 http://www.ebi.ac.uk/interpro/entry/IPR026912 InterPro IPR032466 http://www.ebi.ac.uk/interpro/entry/IPR032466 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3640 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3640 KEGG_Gene eco:b3665 http://www.genome.jp/dbget-bin/www_bget?eco:b3665 KEGG_Orthology KO:K01486 http://www.genome.jp/dbget-bin/www_bget?KO:K01486 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Reaction rn:R01244 http://www.genome.jp/dbget-bin/www_bget?rn:R01244 MINT MINT-1285289 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1285289 OMA CTDDKHL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CTDDKHL PSORT swissprot:ADEC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ADEC_ECOLI PSORT-B swissprot:ADEC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ADEC_ECOLI PSORT2 swissprot:ADEC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ADEC_ECOLI Pfam PF01979 http://pfam.xfam.org/family/PF01979 Pfam PF13382 http://pfam.xfam.org/family/PF13382 Phobius swissprot:ADEC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ADEC_ECOLI PhylomeDB P31441 http://phylomedb.org/?seqid=P31441 ProteinModelPortal P31441 http://www.proteinmodelportal.org/query/uniprot/P31441 PubMed 11440125 http://www.ncbi.nlm.nih.gov/pubmed/11440125 PubMed 12077137 http://www.ncbi.nlm.nih.gov/pubmed/12077137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418121 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418121 RefSeq WP_001065718 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001065718 SMR P31441 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31441 STRING 511145.b3665 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3665&targetmode=cogs STRING COG1001 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1001&targetmode=cogs SUPFAM SSF51338 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51338 SUPFAM SSF51556 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51556 SWISS-2DPAGE P31441 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P31441 TIGRFAMs TIGR01178 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01178 UniProtKB ADEC_ECOLI http://www.uniprot.org/uniprot/ADEC_ECOLI UniProtKB-AC P31441 http://www.uniprot.org/uniprot/P31441 charge swissprot:ADEC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ADEC_ECOLI eggNOG COG1001 http://eggnogapi.embl.de/nog_data/html/tree/COG1001 eggNOG ENOG4105CPN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CPN epestfind swissprot:ADEC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ADEC_ECOLI garnier swissprot:ADEC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ADEC_ECOLI helixturnhelix swissprot:ADEC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ADEC_ECOLI hmoment swissprot:ADEC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ADEC_ECOLI iep swissprot:ADEC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ADEC_ECOLI inforesidue swissprot:ADEC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ADEC_ECOLI octanol swissprot:ADEC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ADEC_ECOLI pepcoil swissprot:ADEC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ADEC_ECOLI pepdigest swissprot:ADEC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ADEC_ECOLI pepinfo swissprot:ADEC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ADEC_ECOLI pepnet swissprot:ADEC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ADEC_ECOLI pepstats swissprot:ADEC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ADEC_ECOLI pepwheel swissprot:ADEC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ADEC_ECOLI pepwindow swissprot:ADEC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ADEC_ECOLI sigcleave swissprot:ADEC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ADEC_ECOLI ## Database ID URL or Descriptions # AltName MSRB_ECOLI Peptide-methionine (R)-S-oxide reductase # BRENDA 1.8.4.12 2026 # BioGrid 4260307 13 # CATALYTIC ACTIVITY Peptide-L-methionine + thioredoxin disulfide + H(2)O = peptide-L-methionine (R)-S-oxide + thioredoxin. {ECO:0000269|PubMed 16251365}. # COFACTOR MSRB_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 16251365}; Note=Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein. {ECO 0000269|PubMed 16251365}; # EcoGene EG12394 msrB # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0005506 iron ion binding; IDA:EcoliWiki. # GO_function GO:0008270 zinc ion binding; IDA:EcoliWiki. # GO_function GO:0033743 peptide-methionine (R)-S-oxide reductase activity; IDA:EcoliWiki. # GO_process GO:0006979 response to oxidative stress; IEA:UniProtKB-HAMAP. # GO_process GO:0030091 protein repair; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # Gene3D 2.170.150.20 -; 1. # HAMAP MF_01400 MsrB # IntAct P0A746 3 # InterPro IPR002579 Met_Sox_Rdtase_MsrB # InterPro IPR011057 Mss4-like # InterPro IPR028427 Met_Sox_Rdtase # KEGG_Brite ko01000 Enzymes # MASS SPECTROMETRY Mass=15319; Mass_error=1; Method=Electrospray; Range=2-137; Evidence={ECO:0000269|PubMed 16251365}; # Organism MSRB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10173 PTHR10173 # PATRIC 32118867 VBIEscCol129921_1851 # PIR B64938 B64938 # PROSITE PS51790 MSRB # Pfam PF01641 SelR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MSRB_ECOLI Peptide methionine sulfoxide reductase MsrB # RefSeq NP_416292 NC_000913.3 # RefSeq WP_001284618 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=X02662; Type=Frameshift; Positions=5; Evidence={ECO 0000305}; # SIMILARITY Belongs to the MsrB Met sulfoxide reductase family. {ECO 0000305}. # SIMILARITY Contains 1 MsrB (methionine-R-sulfoxide reductase) domain. {ECO:0000255|PROSITE-ProRule PRU01126}. # SUPFAM SSF51316 SSF51316 # TIGRFAMs TIGR00357 TIGR00357 # eggNOG COG0229 LUCA # eggNOG ENOG4105E0X Bacteria BLAST swissprot:MSRB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MSRB_ECOLI BioCyc ECOL316407:JW1767-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1767-MONOMER BioCyc EcoCyc:EG12394-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12394-MONOMER BioCyc MetaCyc:EG12394-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12394-MONOMER COG COG0229 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0229 DIP DIP-48167N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48167N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M105509200 http://dx.doi.org/10.1074/jbc.M105509200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1110/ps.051711105 http://dx.doi.org/10.1110/ps.051711105 DOI 10.1111/j.1432-1033.1985.tb08988.x http://dx.doi.org/10.1111/j.1432-1033.1985.tb08988.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.8.4.12 http://www.genome.jp/dbget-bin/www_bget?EC:1.8.4.12 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X02662 http://www.ebi.ac.uk/ena/data/view/X02662 ENZYME 1.8.4.12 http://enzyme.expasy.org/EC/1.8.4.12 EchoBASE EB2295 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2295 EcoGene EG12394 http://www.ecogene.org/geneInfo.php?eg_id=EG12394 EnsemblBacteria AAC74848 http://www.ensemblgenomes.org/id/AAC74848 EnsemblBacteria AAC74848 http://www.ensemblgenomes.org/id/AAC74848 EnsemblBacteria BAA15575 http://www.ensemblgenomes.org/id/BAA15575 EnsemblBacteria BAA15575 http://www.ensemblgenomes.org/id/BAA15575 EnsemblBacteria BAA15575 http://www.ensemblgenomes.org/id/BAA15575 EnsemblBacteria b1778 http://www.ensemblgenomes.org/id/b1778 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0033743 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033743 GO_process GO:0006979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979 GO_process GO:0030091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030091 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 2.170.150.20 http://www.cathdb.info/version/latest/superfamily/2.170.150.20 GeneID 947188 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947188 HAMAP MF_01400 http://hamap.expasy.org/unirule/MF_01400 HOGENOM HOG000243425 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000243425&db=HOGENOM6 InParanoid P0A746 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A746 IntAct P0A746 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A746* IntEnz 1.8.4.12 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.8.4.12 InterPro IPR002579 http://www.ebi.ac.uk/interpro/entry/IPR002579 InterPro IPR011057 http://www.ebi.ac.uk/interpro/entry/IPR011057 InterPro IPR028427 http://www.ebi.ac.uk/interpro/entry/IPR028427 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1767 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1767 KEGG_Gene eco:b1778 http://www.genome.jp/dbget-bin/www_bget?eco:b1778 KEGG_Orthology KO:K07305 http://www.genome.jp/dbget-bin/www_bget?KO:K07305 OMA RIEVQCK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RIEVQCK PANTHER PTHR10173 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10173 PROSITE PS51790 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51790 PSORT swissprot:MSRB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MSRB_ECOLI PSORT-B swissprot:MSRB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MSRB_ECOLI PSORT2 swissprot:MSRB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MSRB_ECOLI Pfam PF01641 http://pfam.xfam.org/family/PF01641 Phobius swissprot:MSRB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MSRB_ECOLI PhylomeDB P0A746 http://phylomedb.org/?seqid=P0A746 ProteinModelPortal P0A746 http://www.proteinmodelportal.org/query/uniprot/P0A746 PubMed 11677230 http://www.ncbi.nlm.nih.gov/pubmed/11677230 PubMed 16251365 http://www.ncbi.nlm.nih.gov/pubmed/16251365 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2990926 http://www.ncbi.nlm.nih.gov/pubmed/2990926 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416292 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416292 RefSeq WP_001284618 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001284618 STRING 511145.b1778 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1778&targetmode=cogs STRING COG0229 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0229&targetmode=cogs SUPFAM SSF51316 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51316 TIGRFAMs TIGR00357 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00357 UniProtKB MSRB_ECOLI http://www.uniprot.org/uniprot/MSRB_ECOLI UniProtKB-AC P0A746 http://www.uniprot.org/uniprot/P0A746 charge swissprot:MSRB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MSRB_ECOLI eggNOG COG0229 http://eggnogapi.embl.de/nog_data/html/tree/COG0229 eggNOG ENOG4105E0X http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E0X epestfind swissprot:MSRB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MSRB_ECOLI garnier swissprot:MSRB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MSRB_ECOLI helixturnhelix swissprot:MSRB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MSRB_ECOLI hmoment swissprot:MSRB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MSRB_ECOLI iep swissprot:MSRB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MSRB_ECOLI inforesidue swissprot:MSRB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MSRB_ECOLI octanol swissprot:MSRB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MSRB_ECOLI pepcoil swissprot:MSRB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MSRB_ECOLI pepdigest swissprot:MSRB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MSRB_ECOLI pepinfo swissprot:MSRB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MSRB_ECOLI pepnet swissprot:MSRB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MSRB_ECOLI pepstats swissprot:MSRB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MSRB_ECOLI pepwheel swissprot:MSRB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MSRB_ECOLI pepwindow swissprot:MSRB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MSRB_ECOLI sigcleave swissprot:MSRB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MSRB_ECOLI ## Database ID URL or Descriptions # BioGrid 4261226 16 # EcoGene EG12814 yhcH # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_process GO:0006950 response to stress # Gene3D 2.60.120.370 -; 1. # InterPro IPR004375 YhcH/YjgK/YiaL # Organism YHCH_ECOLI Escherichia coli (strain K12) # PATRIC 32121866 VBIEscCol129921_3317 # PIR G65113 G65113 # Pfam PF04074 DUF386 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHCH_ECOLI Uncharacterized protein YhcH # RefSeq NP_417688 NC_000913.3 # RefSeq WP_000979882 NZ_LN832404.1 # SIMILARITY Belongs to the TabA/YhcH/YiaL family. {ECO 0000305}. # TIGRFAMs TIGR00022 TIGR00022 # eggNOG COG2731 LUCA # eggNOG ENOG4108R66 Bacteria BLAST swissprot:YHCH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHCH_ECOLI BioCyc ECOL316407:JW3190-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3190-MONOMER BioCyc EcoCyc:G7675-MONOMER http://biocyc.org/getid?id=EcoCyc:G7675-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2665 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2665 EcoGene EG12814 http://www.ecogene.org/geneInfo.php?eg_id=EG12814 EnsemblBacteria AAC76253 http://www.ensemblgenomes.org/id/AAC76253 EnsemblBacteria AAC76253 http://www.ensemblgenomes.org/id/AAC76253 EnsemblBacteria BAE77264 http://www.ensemblgenomes.org/id/BAE77264 EnsemblBacteria BAE77264 http://www.ensemblgenomes.org/id/BAE77264 EnsemblBacteria BAE77264 http://www.ensemblgenomes.org/id/BAE77264 EnsemblBacteria b3221 http://www.ensemblgenomes.org/id/b3221 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 2.60.120.370 http://www.cathdb.info/version/latest/superfamily/2.60.120.370 GeneID 947750 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947750 HOGENOM HOG000282946 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000282946&db=HOGENOM6 InParanoid P45424 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45424 IntAct P45424 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45424* InterPro IPR004375 http://www.ebi.ac.uk/interpro/entry/IPR004375 KEGG_Gene ecj:JW3190 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3190 KEGG_Gene eco:b3221 http://www.genome.jp/dbget-bin/www_bget?eco:b3221 OMA FMNVMEF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FMNVMEF PSORT swissprot:YHCH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHCH_ECOLI PSORT-B swissprot:YHCH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHCH_ECOLI PSORT2 swissprot:YHCH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHCH_ECOLI Pfam PF04074 http://pfam.xfam.org/family/PF04074 Phobius swissprot:YHCH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHCH_ECOLI PhylomeDB P45424 http://phylomedb.org/?seqid=P45424 ProteinModelPortal P45424 http://www.proteinmodelportal.org/query/uniprot/P45424 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417688 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417688 RefSeq WP_000979882 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000979882 SMR P45424 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45424 STRING 511145.b3221 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3221&targetmode=cogs TIGRFAMs TIGR00022 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00022 UniProtKB YHCH_ECOLI http://www.uniprot.org/uniprot/YHCH_ECOLI UniProtKB-AC P45424 http://www.uniprot.org/uniprot/P45424 charge swissprot:YHCH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHCH_ECOLI eggNOG COG2731 http://eggnogapi.embl.de/nog_data/html/tree/COG2731 eggNOG ENOG4108R66 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108R66 epestfind swissprot:YHCH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHCH_ECOLI garnier swissprot:YHCH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHCH_ECOLI helixturnhelix swissprot:YHCH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHCH_ECOLI hmoment swissprot:YHCH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHCH_ECOLI iep swissprot:YHCH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHCH_ECOLI inforesidue swissprot:YHCH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHCH_ECOLI octanol swissprot:YHCH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHCH_ECOLI pepcoil swissprot:YHCH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHCH_ECOLI pepdigest swissprot:YHCH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHCH_ECOLI pepinfo swissprot:YHCH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHCH_ECOLI pepnet swissprot:YHCH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHCH_ECOLI pepstats swissprot:YHCH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHCH_ECOLI pepwheel swissprot:YHCH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHCH_ECOLI pepwindow swissprot:YHCH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHCH_ECOLI sigcleave swissprot:YHCH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHCH_ECOLI ## Database ID URL or Descriptions # AltName RSEA_ECOLI Regulator of SigE # AltName RSEA_ECOLI Sigma-E anti-sigma factor RseA # AltName RSEA_ECOLI Sigma-E factor negative regulatory protein # CAUTION PubMed:9159522 mis-identifies Trp-33 as residue 32. {ECO 0000305}. # CAUTION RSEA_ECOLI In vitro (PubMed 19706448) and in vivo (PubMed 23016873) results on the importance of the identity of residue 148 for cleavage by RseP differ. {ECO 0000305|PubMed 19706448, ECO 0000305|PubMed 23016873}. # DISRUPTION PHENOTYPE RSEA_ECOLI About 10-fold increased sigma-E activity. Neither sigma-E nor RseB associate with the inner membrane. {ECO 0000269|PubMed 11777003, ECO 0000269|PubMed 9159522, ECO 0000269|PubMed 9159523}. # DOMAIN RSEA_ECOLI The C-terminal periplasmic domain (residues 169-186) interacts with RseB and is also the target for DegS; RseB and DegS binding sites do not appreciably overlap. Gln-rich regions (residues 162-169, Q1, and 190-200, Q2) contribute to preventing RseP from acting before DegS. Insertion of 8 consecutive Gln residues into a protein lacking Q1 and Q2 restores DegS- depenedence of RseP cleavage. # DOMAIN RSEA_ECOLI The N-terminal cytosolic domain interacts with sigma-E, and upon overexpression leads to temperature sensitivity above 37 degrees Celsius and cell lysis in stationary phase. After degradation by RseP residues 77-108 bind to SspB, targeting RseA for degradation by the ClpX-ClpP protease. # EcoGene EG12341 rseA # FUNCTION RSEA_ECOLI An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E. Overexpression of RseA blocks sigma-E from acting, results in cell lysis in stationary phase and temperature- sensitivity above 37 degrees Celsius. {ECO 0000269|PubMed 23687042, ECO 0000269|PubMed 9159522, ECO 0000269|PubMed 9159523}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0016989 sigma factor antagonist activity; IMP:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006950 response to stress; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0000988 transcription factor activity, protein binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # INDUCTION RSEA_ECOLI Transiently induced by cold shock in a PNPase-dependent fashion. Upon stress induction (OMPs or heat shock) decreases in under 3 minutes (at protein level). Part of the rpoE-rseA-rseB- rseC operon. {ECO 0000269|PubMed 10500101, ECO 0000269|PubMed 14527658}. # INTERACTION RSEA_ECOLI P0AEE3 degS; NbExp=4; IntAct=EBI-1117560, EBI-1132101; P0AFX9 rseB; NbExp=6; IntAct=EBI-1117560, EBI-1135231; # IntAct P0AFX7 5 # InterPro IPR005572 Anti-sigma_E_RseA_N # InterPro IPR005573 Anti-sigma_E_RseA_C # InterPro IPR026279 RseA # Organism RSEA_ECOLI Escherichia coli (strain K12) # PATRIC 32120543 VBIEscCol129921_2674 # PDB 1OR7 X-ray; 2.00 A; C/F=1-90 # PDB 1YFN X-ray; 1.80 A; E/F/G/H=77-108 # PDB 3M4W X-ray; 2.30 A; E/F/G/H=121-216 # PIR B57255 B57255 # PIRSF PIRSF016938 RseA # PTM RSEA_ECOLI Sequentially cleaved by DegS (a site-1 protease) in its periplasmic domain between Val-148 and Ser-149, then by RseP (a site-2 protease) between positions Ala-108 and Cys-109. The N- terminal fragment is then degraded by primarily ClpX-ClpP in an ATP-dependent fashion. Sequential cleavage by DegS, RseP and ClpX- ClpP frees RpoE from RseA. {ECO 0000269|PubMed 12183368, ECO 0000269|PubMed 12183369, ECO 0000269|PubMed 12679035, ECO 0000269|PubMed 14633997, ECO 0000269|PubMed 15371343, ECO 0000269|PubMed 15496982, ECO 0000269|PubMed 18268014, ECO 0000269|PubMed 18945679, ECO 0000269|PubMed 19706448, ECO 0000269|PubMed 23687042}. # Pfam PF03872 RseA_N # Pfam PF03873 RseA_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RSEA_ECOLI Anti-sigma-E factor RseA # RefSeq NP_417067 NC_000913.3 # RefSeq WP_001168459 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=D13169; Type=Frameshift; Positions=75; Evidence={ECO 0000305}; # SIMILARITY Belongs to the RseA family. {ECO 0000305}. # SUBCELLULAR LOCATION RSEA_ECOLI Cell inner membrane {ECO 0000269|PubMed 11777003, ECO 0000269|PubMed 12183369, ECO 0000269|PubMed 9159522, ECO 0000269|PubMed 9159523}; Single- pass type II membrane protein {ECO 0000269|PubMed 11777003, ECO 0000269|PubMed 12183369, ECO 0000269|PubMed 9159522, ECO 0000269|PubMed 9159523}. Note=Following cleavage by DegS the large fragment of the protein is still in the inner membrane and retains its anti-sigma-E activity. # SUBUNIT RSEA_ECOLI Interacts 1 1 with ECF RNA polymerase sigma-E (RpoE); this inhibits the interaction of sigma-E with the RNA polymerase catalytic core and leads to a decreased expression of sigma-E- regulated genes. Interacts with RseB with 1 1 stoichiometry. The liberated N-terminus (residues 1-108) forms a complex with SspB and RpoE; binding to SspB is competitively inhibited by ssrA-tags, although the 2 proteins bind in opposite directions in SspB's peptide-binding groove. {ECO 0000269|PubMed 11777003, ECO 0000269|PubMed 12016219, ECO 0000269|PubMed 12718891, ECO 0000269|PubMed 14633997, ECO 0000269|PubMed 15371343, ECO 0000269|PubMed 15880122, ECO 0000269|PubMed 17360428, ECO 0000269|PubMed 17692869, ECO 0000269|PubMed 18268014, ECO 0000269|PubMed 18421143, ECO 0000269|PubMed 20512978, ECO 0000269|PubMed 23687042, ECO 0000269|PubMed 9159522, ECO 0000269|PubMed 9159523}. # SUPFAM SSF89069 SSF89069 # eggNOG COG3073 LUCA # eggNOG ENOG41069PW Bacteria BLAST swissprot:RSEA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RSEA_ECOLI BioCyc ECOL316407:JW2556-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2556-MONOMER BioCyc EcoCyc:EG12341-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12341-MONOMER COG COG3073 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3073 DIP DIP-39581N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-39581N DOI 10.1002/pro.393 http://dx.doi.org/10.1002/pro.393 DOI 10.1016/S0092-8674(03)00203-4 http://dx.doi.org/10.1016/S0092-8674(03)00203-4 DOI 10.1016/S0923-2508(03)00167-0 http://dx.doi.org/10.1016/S0923-2508(03)00167-0 DOI 10.1016/S1097-2765(03)00148-5 http://dx.doi.org/10.1016/S1097-2765(03)00148-5 DOI 10.1016/j.jmb.2007.06.039 http://dx.doi.org/10.1016/j.jmb.2007.06.039 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsmb934 http://dx.doi.org/10.1038/nsmb934 DOI 10.1038/sj.emboj.7600449 http://dx.doi.org/10.1038/sj.emboj.7600449 DOI 10.1046/j.1365-2958.1997.3601713.x http://dx.doi.org/10.1046/j.1365-2958.1997.3601713.x DOI 10.1046/j.1365-2958.1997.3611718.x http://dx.doi.org/10.1046/j.1365-2958.1997.3611718.x DOI 10.1073/pnas.0611567104 http://dx.doi.org/10.1073/pnas.0611567104 DOI 10.1073/pnas.0703117104 http://dx.doi.org/10.1073/pnas.0703117104 DOI 10.1073/pnas.0903289106 http://dx.doi.org/10.1073/pnas.0903289106 DOI 10.1074/jbc.M006214200 http://dx.doi.org/10.1074/jbc.M006214200 DOI 10.1074/jbc.M202881200 http://dx.doi.org/10.1074/jbc.M202881200 DOI 10.1074/jbc.M709984200 http://dx.doi.org/10.1074/jbc.M709984200 DOI 10.1074/jbc.M806603200 http://dx.doi.org/10.1074/jbc.M806603200 DOI 10.1093/emboj/cdg602 http://dx.doi.org/10.1093/emboj/cdg602 DOI 10.1101/gad.1002302 http://dx.doi.org/10.1101/gad.1002302 DOI 10.1101/gad.1008902 http://dx.doi.org/10.1101/gad.1008902 DOI 10.1101/gad.1240104 http://dx.doi.org/10.1101/gad.1240104 DOI 10.1101/gad.13.18.2449 http://dx.doi.org/10.1101/gad.13.18.2449 DOI 10.1101/gad.1496707 http://dx.doi.org/10.1101/gad.1496707 DOI 10.1107/S0909049507066319 http://dx.doi.org/10.1107/S0909049507066319 DOI 10.1111/mmi.12053 http://dx.doi.org/10.1111/mmi.12053 DOI 10.1126/science.1235358 http://dx.doi.org/10.1126/science.1235358 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DisProt DP00552 http://www.disprot.org/protein.php?id=DP00552 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D13169 http://www.ebi.ac.uk/ena/data/view/D13169 EMBL D64044 http://www.ebi.ac.uk/ena/data/view/D64044 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U10148 http://www.ebi.ac.uk/ena/data/view/U10148 EMBL U37089 http://www.ebi.ac.uk/ena/data/view/U37089 EMBL U37455 http://www.ebi.ac.uk/ena/data/view/U37455 EchoBASE EB2245 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2245 EcoGene EG12341 http://www.ecogene.org/geneInfo.php?eg_id=EG12341 EnsemblBacteria AAC75625 http://www.ensemblgenomes.org/id/AAC75625 EnsemblBacteria AAC75625 http://www.ensemblgenomes.org/id/AAC75625 EnsemblBacteria BAE76748 http://www.ensemblgenomes.org/id/BAE76748 EnsemblBacteria BAE76748 http://www.ensemblgenomes.org/id/BAE76748 EnsemblBacteria BAE76748 http://www.ensemblgenomes.org/id/BAE76748 EnsemblBacteria b2572 http://www.ensemblgenomes.org/id/b2572 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0016989 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016989 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0000988 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000988 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 947053 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947053 HOGENOM HOG000272262 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000272262&db=HOGENOM6 InParanoid P0AFX7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFX7 IntAct P0AFX7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFX7* InterPro IPR005572 http://www.ebi.ac.uk/interpro/entry/IPR005572 InterPro IPR005573 http://www.ebi.ac.uk/interpro/entry/IPR005573 InterPro IPR026279 http://www.ebi.ac.uk/interpro/entry/IPR026279 KEGG_Gene ecj:JW2556 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2556 KEGG_Gene eco:b2572 http://www.genome.jp/dbget-bin/www_bget?eco:b2572 KEGG_Orthology KO:K03597 http://www.genome.jp/dbget-bin/www_bget?KO:K03597 OMA GVQHYNQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GVQHYNQ PDB 1OR7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1OR7 PDB 1YFN http://www.ebi.ac.uk/pdbe-srv/view/entry/1YFN PDB 3M4W http://www.ebi.ac.uk/pdbe-srv/view/entry/3M4W PDBsum 1OR7 http://www.ebi.ac.uk/pdbsum/1OR7 PDBsum 1YFN http://www.ebi.ac.uk/pdbsum/1YFN PDBsum 3M4W http://www.ebi.ac.uk/pdbsum/3M4W PSORT swissprot:RSEA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RSEA_ECOLI PSORT-B swissprot:RSEA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RSEA_ECOLI PSORT2 swissprot:RSEA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RSEA_ECOLI Pfam PF03872 http://pfam.xfam.org/family/PF03872 Pfam PF03873 http://pfam.xfam.org/family/PF03873 Phobius swissprot:RSEA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RSEA_ECOLI ProteinModelPortal P0AFX7 http://www.proteinmodelportal.org/query/uniprot/P0AFX7 PubMed 10500101 http://www.ncbi.nlm.nih.gov/pubmed/10500101 PubMed 11777003 http://www.ncbi.nlm.nih.gov/pubmed/11777003 PubMed 12016219 http://www.ncbi.nlm.nih.gov/pubmed/12016219 PubMed 12183368 http://www.ncbi.nlm.nih.gov/pubmed/12183368 PubMed 12183369 http://www.ncbi.nlm.nih.gov/pubmed/12183369 PubMed 12679035 http://www.ncbi.nlm.nih.gov/pubmed/12679035 PubMed 12718891 http://www.ncbi.nlm.nih.gov/pubmed/12718891 PubMed 14527658 http://www.ncbi.nlm.nih.gov/pubmed/14527658 PubMed 14633997 http://www.ncbi.nlm.nih.gov/pubmed/14633997 PubMed 15371343 http://www.ncbi.nlm.nih.gov/pubmed/15371343 PubMed 15496982 http://www.ncbi.nlm.nih.gov/pubmed/15496982 PubMed 15880122 http://www.ncbi.nlm.nih.gov/pubmed/15880122 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17210793 http://www.ncbi.nlm.nih.gov/pubmed/17210793 PubMed 17360428 http://www.ncbi.nlm.nih.gov/pubmed/17360428 PubMed 17496148 http://www.ncbi.nlm.nih.gov/pubmed/17496148 PubMed 17692869 http://www.ncbi.nlm.nih.gov/pubmed/17692869 PubMed 18268014 http://www.ncbi.nlm.nih.gov/pubmed/18268014 PubMed 18421143 http://www.ncbi.nlm.nih.gov/pubmed/18421143 PubMed 18945679 http://www.ncbi.nlm.nih.gov/pubmed/18945679 PubMed 19706448 http://www.ncbi.nlm.nih.gov/pubmed/19706448 PubMed 20512978 http://www.ncbi.nlm.nih.gov/pubmed/20512978 PubMed 23016873 http://www.ncbi.nlm.nih.gov/pubmed/23016873 PubMed 23687042 http://www.ncbi.nlm.nih.gov/pubmed/23687042 PubMed 7768826 http://www.ncbi.nlm.nih.gov/pubmed/7768826 PubMed 7889935 http://www.ncbi.nlm.nih.gov/pubmed/7889935 PubMed 9159522 http://www.ncbi.nlm.nih.gov/pubmed/9159522 PubMed 9159523 http://www.ncbi.nlm.nih.gov/pubmed/9159523 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417067 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417067 RefSeq WP_001168459 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001168459 SMR P0AFX7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFX7 STRING 511145.b2572 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2572&targetmode=cogs STRING COG3073 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3073&targetmode=cogs SUPFAM SSF89069 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF89069 UniProtKB RSEA_ECOLI http://www.uniprot.org/uniprot/RSEA_ECOLI UniProtKB-AC P0AFX7 http://www.uniprot.org/uniprot/P0AFX7 charge swissprot:RSEA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RSEA_ECOLI eggNOG COG3073 http://eggnogapi.embl.de/nog_data/html/tree/COG3073 eggNOG ENOG41069PW http://eggnogapi.embl.de/nog_data/html/tree/ENOG41069PW epestfind swissprot:RSEA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RSEA_ECOLI garnier swissprot:RSEA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RSEA_ECOLI helixturnhelix swissprot:RSEA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RSEA_ECOLI hmoment swissprot:RSEA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RSEA_ECOLI iep swissprot:RSEA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RSEA_ECOLI inforesidue swissprot:RSEA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RSEA_ECOLI octanol swissprot:RSEA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RSEA_ECOLI pepcoil swissprot:RSEA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RSEA_ECOLI pepdigest swissprot:RSEA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RSEA_ECOLI pepinfo swissprot:RSEA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RSEA_ECOLI pepnet swissprot:RSEA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RSEA_ECOLI pepstats swissprot:RSEA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RSEA_ECOLI pepwheel swissprot:RSEA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RSEA_ECOLI pepwindow swissprot:RSEA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RSEA_ECOLI sigcleave swissprot:RSEA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RSEA_ECOLI ## Database ID URL or Descriptions # BioGrid 4263320 48 # CATALYTIC ACTIVITY RHLB_ECOLI ATP + H(2)O = ADP + phosphate. {ECO 0000255|HAMAP-Rule MF_00661, ECO 0000269|PubMed 8610017, ECO 0000269|PubMed 9732274}. # ENZYME REGULATION ATPase activity is stimulated by interaction with RNase E. {ECO:0000269|PubMed 9732274}. # EcoGene EG10844 rhlB # FUNCTION RHLB_ECOLI DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA. {ECO 0000255|HAMAP-Rule MF_00661, ECO 0000269|PubMed 12181321, ECO 0000269|PubMed 8610017, ECO 0000269|PubMed 9732274}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003723 RNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0004004 ATP-dependent RNA helicase activity; IBA:GO_Central. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008026 ATP-dependent helicase activity; IDA:EcoCyc. # GO_process GO:0006401 RNA catabolic process; IDA:EcoCyc. # GO_process GO:0010501 RNA secondary structure unwinding; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0004386 helicase activity # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # Gene3D 3.40.50.300 -; 2. # HAMAP MF_00661 DEAD_helicase_RhlB # INTERACTION RHLB_ECOLI P05055 pnp; NbExp=6; IntAct=EBI-555806, EBI-548080; P21513 rne; NbExp=16; IntAct=EBI-555806, EBI-549958; Q1ZS71 rne (xeno); NbExp=4; IntAct=EBI-555806, EBI-8525650; # IntAct P0A8J8 32 # InterPro IPR000629 RNA-helicase_DEAD-box_CS # InterPro IPR001650 Helicase_C # InterPro IPR011545 DEAD/DEAH_box_helicase_dom # InterPro IPR014001 Helicase_ATP-bd # InterPro IPR014014 RNA_helicase_DEAD_Q_motif # InterPro IPR023554 RNA_helicase_ATP-dep_RhlB # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko03018 RNA degradation # Organism RHLB_ECOLI Escherichia coli (strain K12) # PATRIC 32123051 VBIEscCol129921_3895 # PIR G65181 G65181 # PROSITE PS00039 DEAD_ATP_HELICASE # PROSITE PS51192 HELICASE_ATP_BIND_1 # PROSITE PS51194 HELICASE_CTER # PROSITE PS51195 Q_MOTIF # Pfam PF00270 DEAD # Pfam PF00271 Helicase_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ATP-dependent RNA helicase RhlB {ECO:0000255|HAMAP-Rule MF_00661} # RefSeq NP_418227 NC_000913.3 # RefSeq WP_000047499 NZ_LN832404.1 # SIMILARITY Belongs to the DEAD box helicase family. RhlB subfamily. {ECO:0000255|HAMAP-Rule MF_00661}. # SIMILARITY Contains 1 helicase ATP-binding domain. {ECO:0000255|HAMAP-Rule MF_00661}. # SIMILARITY Contains 1 helicase C-terminal domain. {ECO:0000255|HAMAP-Rule MF_00661}. # SMART SM00487 DEXDc # SMART SM00490 HELICc # SUBCELLULAR LOCATION RHLB_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00661, ECO 0000269|PubMed 18337249}. Note=Forms a cytoskeletal-like coiled structure that extends along the length of the cell. Formation of this structure does not require the presence of RNase E, MinD and/or MreB. # SUBUNIT RHLB_ECOLI Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation. Binds to RNase E (rne) and PNPase (pnp). Forms multimers. {ECO 0000255|HAMAP-Rule MF_00661, ECO 0000269|PubMed 10521403, ECO 0000269|PubMed 18337249, ECO 0000269|PubMed 8610017, ECO 0000269|PubMed 9732274}. # SUPFAM SSF52540 SSF52540 # eggNOG COG0513 LUCA # eggNOG ENOG4105C1J Bacteria BLAST swissprot:RHLB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RHLB_ECOLI BioCyc ECOL316407:JW3753-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3753-MONOMER BioCyc EcoCyc:EG10844-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10844-MONOMER BioCyc MetaCyc:EG10844-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10844-MONOMER COG COG0513 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0513 DIP DIP-35644N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35644N DOI 10.1038/381169a0 http://dx.doi.org/10.1038/381169a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M206618200 http://dx.doi.org/10.1074/jbc.M206618200 DOI 10.1074/jbc.M709118200 http://dx.doi.org/10.1074/jbc.M709118200 DOI 10.1101/gad.12.17.2770 http://dx.doi.org/10.1101/gad.12.17.2770 DOI 10.1101/gad.13.19.2594 http://dx.doi.org/10.1101/gad.13.19.2594 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.4.13 {ECO:0000255|HAMAP-Rule:MF_00661} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.4.13 {ECO:0000255|HAMAP-Rule:MF_00661} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M83316 http://www.ebi.ac.uk/ena/data/view/M83316 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X56310 http://www.ebi.ac.uk/ena/data/view/X56310 ENZYME 3.6.4.13 {ECO:0000255|HAMAP-Rule:MF_00661} http://enzyme.expasy.org/EC/3.6.4.13 {ECO:0000255|HAMAP-Rule:MF_00661} EchoBASE EB0837 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0837 EcoGene EG10844 http://www.ecogene.org/geneInfo.php?eg_id=EG10844 EnsemblBacteria AAC76785 http://www.ensemblgenomes.org/id/AAC76785 EnsemblBacteria AAC76785 http://www.ensemblgenomes.org/id/AAC76785 EnsemblBacteria BAE77518 http://www.ensemblgenomes.org/id/BAE77518 EnsemblBacteria BAE77518 http://www.ensemblgenomes.org/id/BAE77518 EnsemblBacteria BAE77518 http://www.ensemblgenomes.org/id/BAE77518 EnsemblBacteria b3780 http://www.ensemblgenomes.org/id/b3780 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0004004 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004004 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008026 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008026 GO_process GO:0006401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006401 GO_process GO:0010501 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010501 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0004386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004386 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948290 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948290 HAMAP MF_00661 http://hamap.expasy.org/unirule/MF_00661 HOGENOM HOG000268807 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000268807&db=HOGENOM6 InParanoid P0A8J8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8J8 IntAct P0A8J8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8J8* IntEnz 3.6.4.13 {ECO:0000255|HAMAP-Rule:MF_00661} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.4.13 {ECO:0000255|HAMAP-Rule:MF_00661} InterPro IPR000629 http://www.ebi.ac.uk/interpro/entry/IPR000629 InterPro IPR001650 http://www.ebi.ac.uk/interpro/entry/IPR001650 InterPro IPR011545 http://www.ebi.ac.uk/interpro/entry/IPR011545 InterPro IPR014001 http://www.ebi.ac.uk/interpro/entry/IPR014001 InterPro IPR014014 http://www.ebi.ac.uk/interpro/entry/IPR014014 InterPro IPR023554 http://www.ebi.ac.uk/interpro/entry/IPR023554 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3753 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3753 KEGG_Gene eco:b3780 http://www.genome.jp/dbget-bin/www_bget?eco:b3780 KEGG_Orthology KO:K03732 http://www.genome.jp/dbget-bin/www_bget?KO:K03732 KEGG_Pathway ko03018 http://www.genome.jp/kegg-bin/show_pathway?ko03018 MINT MINT-8049290 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8049290 OMA FIRDIRY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FIRDIRY PROSITE PS00039 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00039 PROSITE PS51192 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51192 PROSITE PS51194 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51194 PROSITE PS51195 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51195 PSORT swissprot:RHLB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RHLB_ECOLI PSORT-B swissprot:RHLB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RHLB_ECOLI PSORT2 swissprot:RHLB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RHLB_ECOLI Pfam PF00270 http://pfam.xfam.org/family/PF00270 Pfam PF00271 http://pfam.xfam.org/family/PF00271 Phobius swissprot:RHLB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RHLB_ECOLI PhylomeDB P0A8J8 http://phylomedb.org/?seqid=P0A8J8 ProteinModelPortal P0A8J8 http://www.proteinmodelportal.org/query/uniprot/P0A8J8 PubMed 10521403 http://www.ncbi.nlm.nih.gov/pubmed/10521403 PubMed 12181321 http://www.ncbi.nlm.nih.gov/pubmed/12181321 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18337249 http://www.ncbi.nlm.nih.gov/pubmed/18337249 PubMed 1931833 http://www.ncbi.nlm.nih.gov/pubmed/1931833 PubMed 8610017 http://www.ncbi.nlm.nih.gov/pubmed/8610017 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9732274 http://www.ncbi.nlm.nih.gov/pubmed/9732274 RefSeq NP_418227 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418227 RefSeq WP_000047499 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000047499 SMART SM00487 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00487 SMART SM00490 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00490 SMR P0A8J8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8J8 STRING 511145.b3780 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3780&targetmode=cogs STRING COG0513 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0513&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB RHLB_ECOLI http://www.uniprot.org/uniprot/RHLB_ECOLI UniProtKB-AC P0A8J8 http://www.uniprot.org/uniprot/P0A8J8 charge swissprot:RHLB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RHLB_ECOLI eggNOG COG0513 http://eggnogapi.embl.de/nog_data/html/tree/COG0513 eggNOG ENOG4105C1J http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C1J epestfind swissprot:RHLB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RHLB_ECOLI garnier swissprot:RHLB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RHLB_ECOLI helixturnhelix swissprot:RHLB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RHLB_ECOLI hmoment swissprot:RHLB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RHLB_ECOLI iep swissprot:RHLB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RHLB_ECOLI inforesidue swissprot:RHLB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RHLB_ECOLI octanol swissprot:RHLB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RHLB_ECOLI pepcoil swissprot:RHLB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RHLB_ECOLI pepdigest swissprot:RHLB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RHLB_ECOLI pepinfo swissprot:RHLB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RHLB_ECOLI pepnet swissprot:RHLB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RHLB_ECOLI pepstats swissprot:RHLB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RHLB_ECOLI pepwheel swissprot:RHLB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RHLB_ECOLI pepwindow swissprot:RHLB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RHLB_ECOLI sigcleave swissprot:RHLB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RHLB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260278 38 # EcoGene EG13961 sufE # FUNCTION SUFE_ECOLI Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process. Together with the SufBCD complex, it thereby enhances up to 50- fold, the cysteine desulfurase activity of SufS. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Does not affect the selenocysteine lyase activity of SufS. {ECO 0000269|PubMed 12876288, ECO 0000269|PubMed 12941942, ECO 0000269|PubMed 14644425}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0008047 enzyme activator activity; IDA:EcoCyc. # GO_function GO:0097163 sulfur carrier activity; IDA:EcoCyc. # GO_process GO:0006979 response to oxidative stress; IMP:EcoCyc. # GO_process GO:0016226 iron-sulfur cluster assembly; IEA:InterPro. # GO_process GO:0031162 sulfur incorporation into metallo-sulfur cluster; IDA:EcoCyc. # GO_process GO:0043085 positive regulation of catalytic activity; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0030234 enzyme regulator activity # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0051186 cofactor metabolic process # HAMAP MF_01832 SufE # INDUCTION SUFE_ECOLI Suf operon is under both the Fe-dependent Fur repressor and the oxidative stress dependent OxyR activator. # INTERACTION SUFE_ECOLI P77444 sufS; NbExp=3; IntAct=EBI-1124973, EBI-1124981; # IntAct P76194 8 # InterPro IPR003808 Fe-S_metab-assoc_dom # InterPro IPR023939 Cysteine_desulfuration_SufE # Organism SUFE_ECOLI Escherichia coli (strain K12) # PATHWAY SUFE_ECOLI Cofactor biosynthesis; iron-sulfur cluster biosynthesis. # PATRIC 32118664 VBIEscCol129921_1750 # PDB 1MZG X-ray; 2.00 A; A/B=1-138 # PIR G64925 G64925 # Pfam PF02657 SufE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SUFE_ECOLI Cysteine desulfuration protein SufE # RefSeq NP_416194 NC_000913.3 # RefSeq WP_001196530 NZ_LN832404.1 # SIMILARITY Belongs to the SufE family. {ECO 0000305}. # SUBCELLULAR LOCATION SUFE_ECOLI Cytoplasm {ECO 0000250}. # SUBUNIT SUFE_ECOLI Homodimer. Interacts with SufS. {ECO 0000269|PubMed 12876288, ECO 0000269|PubMed 12941942, ECO 0000269|PubMed 14644425}. # eggNOG COG2166 LUCA # eggNOG ENOG4105P9C Bacteria BLAST swissprot:SUFE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SUFE_ECOLI BioCyc ECOL316407:JW1669-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1669-MONOMER BioCyc EcoCyc:G6905-MONOMER http://biocyc.org/getid?id=EcoCyc:G6905-MONOMER COG COG2166 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2166 DIP DIP-10941N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10941N DOI 10.1016/S0014-5793(03)01244-4 http://dx.doi.org/10.1016/S0014-5793(03)01244-4 DOI 10.1016/j.jmb.2004.08.074 http://dx.doi.org/10.1016/j.jmb.2004.08.074 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M305953200 http://dx.doi.org/10.1074/jbc.M305953200 DOI 10.1074/jbc.M308004200 http://dx.doi.org/10.1074/jbc.M308004200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3719 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3719 EcoGene EG13961 http://www.ecogene.org/geneInfo.php?eg_id=EG13961 EnsemblBacteria AAC74749 http://www.ensemblgenomes.org/id/AAC74749 EnsemblBacteria AAC74749 http://www.ensemblgenomes.org/id/AAC74749 EnsemblBacteria BAE76500 http://www.ensemblgenomes.org/id/BAE76500 EnsemblBacteria BAE76500 http://www.ensemblgenomes.org/id/BAE76500 EnsemblBacteria BAE76500 http://www.ensemblgenomes.org/id/BAE76500 EnsemblBacteria b1679 http://www.ensemblgenomes.org/id/b1679 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0008047 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008047 GO_function GO:0097163 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097163 GO_process GO:0006979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979 GO_process GO:0016226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016226 GO_process GO:0031162 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031162 GO_process GO:0043085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043085 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GeneID 946173 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946173 HAMAP MF_01832 http://hamap.expasy.org/unirule/MF_01832 HOGENOM HOG000285040 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000285040&db=HOGENOM6 InParanoid P76194 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76194 IntAct P76194 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76194* InterPro IPR003808 http://www.ebi.ac.uk/interpro/entry/IPR003808 InterPro IPR023939 http://www.ebi.ac.uk/interpro/entry/IPR023939 KEGG_Gene ecj:JW1669 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1669 KEGG_Gene eco:b1679 http://www.genome.jp/dbget-bin/www_bget?eco:b1679 KEGG_Orthology KO:K02426 http://www.genome.jp/dbget-bin/www_bget?KO:K02426 OMA NIIQGCQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NIIQGCQ PDB 1MZG http://www.ebi.ac.uk/pdbe-srv/view/entry/1MZG PDBsum 1MZG http://www.ebi.ac.uk/pdbsum/1MZG PSORT swissprot:SUFE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SUFE_ECOLI PSORT-B swissprot:SUFE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SUFE_ECOLI PSORT2 swissprot:SUFE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SUFE_ECOLI Pfam PF02657 http://pfam.xfam.org/family/PF02657 Phobius swissprot:SUFE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SUFE_ECOLI PhylomeDB P76194 http://phylomedb.org/?seqid=P76194 ProteinModelPortal P76194 http://www.proteinmodelportal.org/query/uniprot/P76194 PubMed 10322040 http://www.ncbi.nlm.nih.gov/pubmed/10322040 PubMed 12876288 http://www.ncbi.nlm.nih.gov/pubmed/12876288 PubMed 12941942 http://www.ncbi.nlm.nih.gov/pubmed/12941942 PubMed 14644425 http://www.ncbi.nlm.nih.gov/pubmed/14644425 PubMed 15522304 http://www.ncbi.nlm.nih.gov/pubmed/15522304 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416194 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416194 RefSeq WP_001196530 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001196530 SMR P76194 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76194 STRING 511145.b1679 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1679&targetmode=cogs STRING COG2166 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2166&targetmode=cogs UniProtKB SUFE_ECOLI http://www.uniprot.org/uniprot/SUFE_ECOLI UniProtKB-AC P76194 http://www.uniprot.org/uniprot/P76194 charge swissprot:SUFE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SUFE_ECOLI eggNOG COG2166 http://eggnogapi.embl.de/nog_data/html/tree/COG2166 eggNOG ENOG4105P9C http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105P9C epestfind swissprot:SUFE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SUFE_ECOLI garnier swissprot:SUFE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SUFE_ECOLI helixturnhelix swissprot:SUFE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SUFE_ECOLI hmoment swissprot:SUFE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SUFE_ECOLI iep swissprot:SUFE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SUFE_ECOLI inforesidue swissprot:SUFE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SUFE_ECOLI octanol swissprot:SUFE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SUFE_ECOLI pepcoil swissprot:SUFE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SUFE_ECOLI pepdigest swissprot:SUFE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SUFE_ECOLI pepinfo swissprot:SUFE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SUFE_ECOLI pepnet swissprot:SUFE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SUFE_ECOLI pepstats swissprot:SUFE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SUFE_ECOLI pepwheel swissprot:SUFE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SUFE_ECOLI pepwindow swissprot:SUFE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SUFE_ECOLI sigcleave swissprot:SUFE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SUFE_ECOLI ## Database ID URL or Descriptions # BioGrid 4259343 5 # EcoGene EG12107 ppdD # FUNCTION PPDD_ECOLI Not yet known. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_component GO:0009986 cell surface; IBA:GO_Central. # GO_component GO:0044096 type IV pilus; IBA:GO_Central. # GO_process GO:0043107 type IV pilus-dependent motility; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_process GO:0048870 cell motility # InterPro IPR012902 N_methyl_site # KEGG_Brite ko02044 Secretion system # Organism PPDD_ECOLI Escherichia coli (strain K12) # PATRIC 32115317 VBIEscCol129921_0110 # PIR D64733 D64733 # PROSITE PS00409 PROKAR_NTER_METHYL # Pfam PF07963 N_methyl # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PPDD_ECOLI Prepilin peptidase-dependent protein D # RefSeq NP_414650 NC_000913.3 # RefSeq WP_000360904 NZ_LN832404.1 # SIMILARITY Belongs to the N-Me-Phe pilin family. {ECO 0000305}. # SUBCELLULAR LOCATION PPDD_ECOLI Fimbrium. # TIGRFAMs TIGR02532 IV_pilin_GFxxxE # eggNOG COG4969 LUCA # eggNOG ENOG4108ZUW Bacteria BLAST swissprot:PPDD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PPDD_ECOLI BioCyc ECOL316407:JW0104-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0104-MONOMER BioCyc EcoCyc:EG12107-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12107-MONOMER COG COG2165 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2165 DOI 10.1016/0378-1119(94)90851-6 http://dx.doi.org/10.1016/0378-1119(94)90851-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L20834 http://www.ebi.ac.uk/ena/data/view/L20834 EMBL L28105 http://www.ebi.ac.uk/ena/data/view/L28105 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2031 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2031 EcoGene EG12107 http://www.ecogene.org/geneInfo.php?eg_id=EG12107 EnsemblBacteria AAC73219 http://www.ensemblgenomes.org/id/AAC73219 EnsemblBacteria AAC73219 http://www.ensemblgenomes.org/id/AAC73219 EnsemblBacteria BAB96678 http://www.ensemblgenomes.org/id/BAB96678 EnsemblBacteria BAB96678 http://www.ensemblgenomes.org/id/BAB96678 EnsemblBacteria BAB96678 http://www.ensemblgenomes.org/id/BAB96678 EnsemblBacteria b0108 http://www.ensemblgenomes.org/id/b0108 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0009986 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986 GO_component GO:0044096 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044096 GO_process GO:0043107 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043107 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 GeneID 945817 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945817 HOGENOM HOG000008197 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000008197&db=HOGENOM6 InParanoid P36647 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P36647 InterPro IPR012902 http://www.ebi.ac.uk/interpro/entry/IPR012902 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW0104 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0104 KEGG_Gene eco:b0108 http://www.genome.jp/dbget-bin/www_bget?eco:b0108 KEGG_Orthology KO:K02682 http://www.genome.jp/dbget-bin/www_bget?KO:K02682 OMA IPAYQGY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IPAYQGY PROSITE PS00409 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00409 PSORT swissprot:PPDD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PPDD_ECOLI PSORT-B swissprot:PPDD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PPDD_ECOLI PSORT2 swissprot:PPDD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PPDD_ECOLI Pfam PF07963 http://pfam.xfam.org/family/PF07963 Phobius swissprot:PPDD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PPDD_ECOLI ProteinModelPortal P36647 http://www.proteinmodelportal.org/query/uniprot/P36647 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7959070 http://www.ncbi.nlm.nih.gov/pubmed/7959070 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414650 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414650 RefSeq WP_000360904 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000360904 SMR P36647 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P36647 STRING 511145.b0108 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0108&targetmode=cogs STRING COG2165 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2165&targetmode=cogs TIGRFAMs TIGR02532 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02532 UniProtKB PPDD_ECOLI http://www.uniprot.org/uniprot/PPDD_ECOLI UniProtKB-AC P36647 http://www.uniprot.org/uniprot/P36647 charge swissprot:PPDD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PPDD_ECOLI eggNOG COG4969 http://eggnogapi.embl.de/nog_data/html/tree/COG4969 eggNOG ENOG4108ZUW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZUW epestfind swissprot:PPDD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PPDD_ECOLI garnier swissprot:PPDD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PPDD_ECOLI helixturnhelix swissprot:PPDD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PPDD_ECOLI hmoment swissprot:PPDD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PPDD_ECOLI iep swissprot:PPDD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PPDD_ECOLI inforesidue swissprot:PPDD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PPDD_ECOLI octanol swissprot:PPDD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PPDD_ECOLI pepcoil swissprot:PPDD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PPDD_ECOLI pepdigest swissprot:PPDD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PPDD_ECOLI pepinfo swissprot:PPDD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PPDD_ECOLI pepnet swissprot:PPDD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PPDD_ECOLI pepstats swissprot:PPDD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PPDD_ECOLI pepwheel swissprot:PPDD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PPDD_ECOLI pepwindow swissprot:PPDD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PPDD_ECOLI sigcleave swissprot:PPDD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PPDD_ECOLI ## Database ID URL or Descriptions # AltName Diphosphoryl transfer protein {ECO:0000303|PubMed 8013873} # AltName EIIA-Fru {ECO:0000250|UniProtKB P17127} # AltName EIII-Fru {ECO:0000250|UniProtKB P17127} # AltName Fructose-specific phosphotransferase enzyme IIA component {ECO:0000303|PubMed 8013873} # AltName Phosphotransferase FPr protein {ECO:0000250|UniProtKB P17127} # AltName Pseudo-HPr {ECO:0000250|UniProtKB P17127} # AltName Pseudo-HPr {ECO:0000250|UniProtKB P17127} # BioGrid 4260464 13 # CATALYTIC ACTIVITY PTFAH_ECOLI [Protein]-N(pi)-phospho-L-histidine + D- fructose(Side 1) = [protein]-L-histidine + D-fructose 1- phosphate(Side 2). {ECO 0000250|UniProtKB P20966, ECO 0000305|PubMed 3510127}. # CDD cd00367 PTS-HPr_like # DOMAIN PTFAH_ECOLI In contrast to classical PTS systems, the fructose- specific PTS has no requirement for HPr; FruB combines a IIA domain with a HPr domain. {ECO 0000305|PubMed 3510127}. # DOMAIN PTFAH_ECOLI The PTS EIIA type-2 domain is phosphorylated by phospho- HPr on a histidyl residue. Then, it transfers the phosphoryl group to the PTS EIIB type-2 domain. {ECO 0000255|PROSITE- ProRule PRU00417}. # EcoGene EG10005 fruB # FUNCTION PTFAH_ECOLI The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FruAB PTS system is involved in fructose transport. {ECO 0000269|PubMed 3510127, ECO 0000305|PubMed 8013873}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_component GO:0019897 extrinsic component of plasma membrane; IDA:EcoCyc. # GO_function GO:0016301 kinase activity; IEA:UniProtKB-KW. # GO_function GO:0022877 protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity; IDA:EcoCyc. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IDA:EcoCyc. # GO_process GO:0032445 fructose import; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # Gene3D 3.30.1340.10 -; 1. # Gene3D 3.40.930.10 -; 2. # INDUCTION Induced by fructose and repressed by FruR. {ECO:0000250|UniProtKB P17127}. # IntAct P69811 7 # InterPro IPR000032 HPr-like # InterPro IPR001020 PTS_HPr_His_P_site # InterPro IPR002114 PTS_HPr_Ser_P_site # InterPro IPR002178 PTS_EIIA_type-2_dom # InterPro IPR016152 PTrfase/Anion_transptr # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02060 Phosphotransferase system (PTS) # Organism PTFAH_ECOLI Escherichia coli (strain K12) # PATRIC 32119687 VBIEscCol129921_2254 # PIR I53564 I53564 # PRINTS PR00107 PHOSPHOCPHPR # PROSITE PS00369 PTS_HPR_HIS # PROSITE PS00372 PTS_EIIA_TYPE_2_HIS # PROSITE PS00589 PTS_HPR_SER # PROSITE PS51094 PTS_EIIA_TYPE_2 # PROSITE PS51350 PTS_HPR_DOM # Pfam PF00359 PTS_EIIA_2 # Pfam PF00381 PTS-HPr # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Multiphosphoryl transfer protein {ECO:0000250|UniProtKB P44715} # RecName PTS system fructose-specific EIIA component {ECO:0000303|PubMed 8013873} # RecName Phosphocarrier protein HPr {ECO:0000250|UniProtKB P17127} # RefSeq NP_416674 NC_000913.3 # RefSeq WP_000487246 NZ_LN832404.1 # SIMILARITY Contains 1 HPr domain. {ECO:0000255|PROSITE- ProRule PRU00681}. # SIMILARITY Contains 1 PTS EIIA type-2 domain. {ECO:0000255|PROSITE-ProRule PRU00417}. # SUBCELLULAR LOCATION PTFAH_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF55594 SSF55594 # SUPFAM SSF55804 SSF55804; 2 # TCDB 4.A.2.1 the pts fructose-mannitol (fru) family # TIGRFAMs TIGR01003 PTS_HPr_family # eggNOG COG1925 LUCA # eggNOG COG4668 LUCA # eggNOG ENOG4105DTZ Bacteria BLAST swissprot:PTFAH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTFAH_ECOLI BioCyc ECOL316407:JW2156-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2156-MONOMER BioCyc EcoCyc:FRUB-MONOMER http://biocyc.org/getid?id=EcoCyc:FRUB-MONOMER BioCyc MetaCyc:FRUB-MONOMER http://biocyc.org/getid?id=MetaCyc:FRUB-MONOMER COG COG1925 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1925 DIP DIP-48096N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48096N DOI 10.1016/0014-5793(86)80042-4 http://dx.doi.org/10.1016/0014-5793(86)80042-4 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1098/rspb.1990.0108 http://dx.doi.org/10.1098/rspb.1990.0108 DOI 10.1111/j.1574-6968.1994.tb06819.x http://dx.doi.org/10.1111/j.1574-6968.1994.tb06819.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.202 {ECO:0000250|UniProtKB:P20966, ECO:0000305|PubMed:3510127} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.202 {ECO:0000250|UniProtKB:P20966, ECO:0000305|PubMed:3510127} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL S72443 http://www.ebi.ac.uk/ena/data/view/S72443 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X53948 http://www.ebi.ac.uk/ena/data/view/X53948 ENZYME 2.7.1.202 {ECO:0000250|UniProtKB:P20966, ECO:0000305|PubMed:3510127} http://enzyme.expasy.org/EC/2.7.1.202 {ECO:0000250|UniProtKB:P20966, ECO:0000305|PubMed:3510127} EchoBASE EB0005 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0005 EcoGene EG10005 http://www.ecogene.org/geneInfo.php?eg_id=EG10005 EnsemblBacteria AAC75230 http://www.ensemblgenomes.org/id/AAC75230 EnsemblBacteria AAC75230 http://www.ensemblgenomes.org/id/AAC75230 EnsemblBacteria BAA15978 http://www.ensemblgenomes.org/id/BAA15978 EnsemblBacteria BAA15978 http://www.ensemblgenomes.org/id/BAA15978 EnsemblBacteria BAA15978 http://www.ensemblgenomes.org/id/BAA15978 EnsemblBacteria b2169 http://www.ensemblgenomes.org/id/b2169 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0019897 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019897 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_function GO:0022877 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022877 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GO_process GO:0032445 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032445 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.30.1340.10 http://www.cathdb.info/version/latest/superfamily/3.30.1340.10 Gene3D 3.40.930.10 http://www.cathdb.info/version/latest/superfamily/3.40.930.10 GeneID 946677 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946677 HOGENOM HOG000278131 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278131&db=HOGENOM6 IntAct P69811 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69811* IntEnz 2.7.1.202 {ECO:0000250|UniProtKB:P20966, ECO:0000305|PubMed:3510127} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.202 {ECO:0000250|UniProtKB:P20966, ECO:0000305|PubMed:3510127} InterPro IPR000032 http://www.ebi.ac.uk/interpro/entry/IPR000032 InterPro IPR001020 http://www.ebi.ac.uk/interpro/entry/IPR001020 InterPro IPR002114 http://www.ebi.ac.uk/interpro/entry/IPR002114 InterPro IPR002178 http://www.ebi.ac.uk/interpro/entry/IPR002178 InterPro IPR016152 http://www.ebi.ac.uk/interpro/entry/IPR016152 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2156 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2156 KEGG_Gene eco:b2169 http://www.genome.jp/dbget-bin/www_bget?eco:b2169 KEGG_Orthology KO:K11183 http://www.genome.jp/dbget-bin/www_bget?KO:K11183 KEGG_Pathway ko02060 http://www.genome.jp/kegg-bin/show_pathway?ko02060 MINT MINT-1263101 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1263101 OMA QGIEWGE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QGIEWGE PRINTS PR00107 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00107 PROSITE PS00369 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00369 PROSITE PS00372 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00372 PROSITE PS00589 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00589 PROSITE PS51094 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51094 PROSITE PS51350 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51350 PSORT swissprot:PTFAH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTFAH_ECOLI PSORT-B swissprot:PTFAH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTFAH_ECOLI PSORT2 swissprot:PTFAH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTFAH_ECOLI Pfam PF00359 http://pfam.xfam.org/family/PF00359 Pfam PF00381 http://pfam.xfam.org/family/PF00381 Phobius swissprot:PTFAH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTFAH_ECOLI ProteinModelPortal P69811 http://www.proteinmodelportal.org/query/uniprot/P69811 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1981619 http://www.ncbi.nlm.nih.gov/pubmed/1981619 PubMed 3510127 http://www.ncbi.nlm.nih.gov/pubmed/3510127 PubMed 8013873 http://www.ncbi.nlm.nih.gov/pubmed/8013873 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416674 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416674 RefSeq WP_000487246 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000487246 SMR P69811 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69811 STRING 511145.b2169 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2169&targetmode=cogs STRING COG1925 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1925&targetmode=cogs SUPFAM SSF55594 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55594 SUPFAM SSF55804 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55804 SWISS-2DPAGE P69811 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P69811 TCDB 4.A.2.1 http://www.tcdb.org/search/result.php?tc=4.A.2.1 TIGRFAMs TIGR01003 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01003 UniProtKB PTFAH_ECOLI http://www.uniprot.org/uniprot/PTFAH_ECOLI UniProtKB-AC P69811 http://www.uniprot.org/uniprot/P69811 charge swissprot:PTFAH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTFAH_ECOLI eggNOG COG1925 http://eggnogapi.embl.de/nog_data/html/tree/COG1925 eggNOG COG4668 http://eggnogapi.embl.de/nog_data/html/tree/COG4668 eggNOG ENOG4105DTZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DTZ epestfind swissprot:PTFAH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTFAH_ECOLI garnier swissprot:PTFAH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTFAH_ECOLI helixturnhelix swissprot:PTFAH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTFAH_ECOLI hmoment swissprot:PTFAH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTFAH_ECOLI iep swissprot:PTFAH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTFAH_ECOLI inforesidue swissprot:PTFAH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTFAH_ECOLI octanol swissprot:PTFAH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTFAH_ECOLI pepcoil swissprot:PTFAH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTFAH_ECOLI pepdigest swissprot:PTFAH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTFAH_ECOLI pepinfo swissprot:PTFAH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTFAH_ECOLI pepnet swissprot:PTFAH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTFAH_ECOLI pepstats swissprot:PTFAH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTFAH_ECOLI pepwheel swissprot:PTFAH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTFAH_ECOLI pepwindow swissprot:PTFAH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTFAH_ECOLI sigcleave swissprot:PTFAH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTFAH_ECOLI ## Database ID URL or Descriptions # BioGrid 4263155 284 # EcoGene EG13721 yccS # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR010019 Integral_membrane_YccS # InterPro IPR010020 Integral_membrane_YCCS_YHJK # InterPro IPR032692 YccS_N # Organism YCCS_ECOLI Escherichia coli (strain K12) # PATRIC 32117139 VBIEscCol129921_0994 # PIR G64836 G64836 # Pfam PF12805 FUSC-like # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCCS_ECOLI Inner membrane protein YccS # RefSeq NP_415480 NC_000913.3 # RefSeq WP_001382153 NZ_LN832404.1 # SIMILARITY Belongs to the YccS/YhfK family. {ECO 0000305}. # SUBCELLULAR LOCATION YCCS_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.85.1 the aromatic acid exporter (arae) family # TIGRFAMs TIGR01666 YCCS # TIGRFAMs TIGR01667 YCCS_YHJK # eggNOG COG1289 LUCA # eggNOG ENOG4105EM2 Bacteria BLAST swissprot:YCCS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCCS_ECOLI BioCyc ECOL316407:JW5128-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5128-MONOMER BioCyc EcoCyc:G6495-MONOMER http://biocyc.org/getid?id=EcoCyc:G6495-MONOMER DIP DIP-11498N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11498N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3485 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3485 EcoGene EG13721 http://www.ecogene.org/geneInfo.php?eg_id=EG13721 EnsemblBacteria AAC74046 http://www.ensemblgenomes.org/id/AAC74046 EnsemblBacteria AAC74046 http://www.ensemblgenomes.org/id/AAC74046 EnsemblBacteria BAA35718 http://www.ensemblgenomes.org/id/BAA35718 EnsemblBacteria BAA35718 http://www.ensemblgenomes.org/id/BAA35718 EnsemblBacteria BAA35718 http://www.ensemblgenomes.org/id/BAA35718 EnsemblBacteria b0960 http://www.ensemblgenomes.org/id/b0960 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 947001 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947001 HOGENOM HOG000279479 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000279479&db=HOGENOM6 InParanoid P75870 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75870 IntAct P75870 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75870* InterPro IPR010019 http://www.ebi.ac.uk/interpro/entry/IPR010019 InterPro IPR010020 http://www.ebi.ac.uk/interpro/entry/IPR010020 InterPro IPR032692 http://www.ebi.ac.uk/interpro/entry/IPR032692 KEGG_Gene ecj:JW5128 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5128 KEGG_Gene eco:b0960 http://www.genome.jp/dbget-bin/www_bget?eco:b0960 OMA YSTIAFG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YSTIAFG PSORT swissprot:YCCS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCCS_ECOLI PSORT-B swissprot:YCCS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCCS_ECOLI PSORT2 swissprot:YCCS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCCS_ECOLI Pfam PF12805 http://pfam.xfam.org/family/PF12805 Phobius swissprot:YCCS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCCS_ECOLI PhylomeDB P75870 http://phylomedb.org/?seqid=P75870 ProteinModelPortal P75870 http://www.proteinmodelportal.org/query/uniprot/P75870 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415480 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415480 RefSeq WP_001382153 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001382153 SMR P75870 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75870 STRING 511145.b0960 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0960&targetmode=cogs TCDB 2.A.85.1 http://www.tcdb.org/search/result.php?tc=2.A.85.1 TIGRFAMs TIGR01666 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01666 TIGRFAMs TIGR01667 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01667 UniProtKB YCCS_ECOLI http://www.uniprot.org/uniprot/YCCS_ECOLI UniProtKB-AC P75870 http://www.uniprot.org/uniprot/P75870 charge swissprot:YCCS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCCS_ECOLI eggNOG COG1289 http://eggnogapi.embl.de/nog_data/html/tree/COG1289 eggNOG ENOG4105EM2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EM2 epestfind swissprot:YCCS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCCS_ECOLI garnier swissprot:YCCS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCCS_ECOLI helixturnhelix swissprot:YCCS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCCS_ECOLI hmoment swissprot:YCCS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCCS_ECOLI iep swissprot:YCCS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCCS_ECOLI inforesidue swissprot:YCCS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCCS_ECOLI octanol swissprot:YCCS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCCS_ECOLI pepcoil swissprot:YCCS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCCS_ECOLI pepdigest swissprot:YCCS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCCS_ECOLI pepinfo swissprot:YCCS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCCS_ECOLI pepnet swissprot:YCCS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCCS_ECOLI pepstats swissprot:YCCS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCCS_ECOLI pepwheel swissprot:YCCS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCCS_ECOLI pepwindow swissprot:YCCS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCCS_ECOLI sigcleave swissprot:YCCS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCCS_ECOLI ## Database ID URL or Descriptions # AltName APPC_ECOLI Cytochrome bd-II oxidase subunit I # BioGrid 4260039 178 # CATALYTIC ACTIVITY APPC_ECOLI 2 ubiquinol + O(2) + n H(+)(Side 1) = 2 ubiquinone + 2 H(2)O + n H(+)(Side 2). # CAUTION Was originally thought not to translocate protons. {ECO:0000305|PubMed 19542282}. # COFACTOR APPC_ECOLI Name=heme; Xref=ChEBI CHEBI 30413; Evidence={ECO 0000305}; Note=May bind up to 3 heme groups per complex. {ECO 0000305}; # DISRUPTION PHENOTYPE APPC_ECOLI 3-fold decreased ubiquinone levels but no change in redox levels of the ubiquinone pool (in aerobically grown minimal medium with glucose). {ECO 0000269|PubMed 19542282, ECO 0000269|PubMed 21987791, ECO 0000269|PubMed 22843529}. # ENZYME REGULATION Inhibited by cyanide; is more sensitive to cyanide than cytochrome bd-I oxidase. {ECO:0000269|PubMed 8626304}. # EcoGene EG11380 appC # FUNCTION APPC_ECOLI A terminal oxidase that catalyzes quinol-dependent, Na(+)-independent oxygen uptake. Prefers menadiol over other quinols although ubiquinol was not tested (PubMed 8626304). Generates a proton motive force using protons and electrons from opposite sides of the membrane to generate H(2)O, transferring 1 proton/electron. {ECO 0000269|PubMed 19542282, ECO 0000269|PubMed 21987791, ECO 0000269|PubMed 22843529, ECO 0000269|PubMed 8626304}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_component GO:0070069 cytochrome complex; IDA:EcoCyc. # GO_function GO:0009055 electron carrier activity; IDA:EcoCyc. # GO_function GO:0016682 oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006119 oxidative phosphorylation; IEA:UniProtKB-UniPathway. # GO_process GO:0019646 aerobic electron transport chain; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # INDUCTION Induced when bacterial cultures reach stationary phase; synthesis is triggered by phosphate starvation or a shift from aerobic to anaerobic conditions. {ECO:0000269|PubMed 1658595}. # IntAct P26459 2 # InterPro IPR002585 Cyt-d_ubiquinol_oxidase_su_1 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00190 Oxidative phosphorylation # KEGG_Pathway ko02020 Two-component system # Organism APPC_ECOLI Escherichia coli (strain K12) # PATHWAY APPC_ECOLI Energy metabolism; oxidative phosphorylation. # PATRIC 32117177 VBIEscCol129921_1012 # PIR S17958 S17958 # PTM APPC_ECOLI The N-terminus is blocked. # Pfam PF01654 Cyt_bd_oxida_I # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName APPC_ECOLI Cytochrome bd-II ubiquinol oxidase subunit 1 # RefSeq NP_415497 NC_000913.3 # RefSeq WP_000263582 NZ_LN832404.1 # SIMILARITY Belongs to the cytochrome ubiquinol oxidase subunit 1 family. {ECO 0000305}. # SUBCELLULAR LOCATION APPC_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # SUBUNIT Heterodimer of subunits I and II. {ECO:0000305|PubMed 8626304}. # eggNOG COG1271 LUCA # eggNOG ENOG4105C4M Bacteria BLAST swissprot:APPC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:APPC_ECOLI BioCyc ECOL316407:JW0960-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0960-MONOMER BioCyc EcoCyc:APPC-MONOMER http://biocyc.org/getid?id=EcoCyc:APPC-MONOMER BioCyc MetaCyc:APPC-MONOMER http://biocyc.org/getid?id=MetaCyc:APPC-MONOMER COG COG1271 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1271 DIP DIP-9119N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9119N DOI 10.1007/BF00267454 http://dx.doi.org/10.1007/BF00267454 DOI 10.1016/j.bbabio.2011.06.016 http://dx.doi.org/10.1016/j.bbabio.2011.06.016 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.1108217108 http://dx.doi.org/10.1073/pnas.1108217108 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AEM.01507-12 http://dx.doi.org/10.1128/AEM.01507-12 DOI 10.1128/JB.00562-09 http://dx.doi.org/10.1128/JB.00562-09 EC_number EC:1.10.3.10 http://www.genome.jp/dbget-bin/www_bget?EC:1.10.3.10 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL S63811 http://www.ebi.ac.uk/ena/data/view/S63811 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.10.3.10 http://enzyme.expasy.org/EC/1.10.3.10 EchoBASE EB1354 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1354 EcoGene EG11380 http://www.ecogene.org/geneInfo.php?eg_id=EG11380 EnsemblBacteria AAC74063 http://www.ensemblgenomes.org/id/AAC74063 EnsemblBacteria AAC74063 http://www.ensemblgenomes.org/id/AAC74063 EnsemblBacteria BAA35743 http://www.ensemblgenomes.org/id/BAA35743 EnsemblBacteria BAA35743 http://www.ensemblgenomes.org/id/BAA35743 EnsemblBacteria BAA35743 http://www.ensemblgenomes.org/id/BAA35743 EnsemblBacteria b0978 http://www.ensemblgenomes.org/id/b0978 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0070069 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070069 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0016682 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016682 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006119 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006119 GO_process GO:0019646 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019646 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 945585 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945585 HOGENOM HOG000084938 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000084938&db=HOGENOM6 InParanoid P26459 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P26459 IntAct P26459 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P26459* IntEnz 1.10.3.10 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.10.3.10 InterPro IPR002585 http://www.ebi.ac.uk/interpro/entry/IPR002585 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0960 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0960 KEGG_Gene eco:b0978 http://www.genome.jp/dbget-bin/www_bget?eco:b0978 KEGG_Orthology KO:K00425 http://www.genome.jp/dbget-bin/www_bget?KO:K00425 KEGG_Pathway ko00190 http://www.genome.jp/kegg-bin/show_pathway?ko00190 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA WGRLPKL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WGRLPKL PSORT swissprot:APPC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:APPC_ECOLI PSORT-B swissprot:APPC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:APPC_ECOLI PSORT2 swissprot:APPC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:APPC_ECOLI Pfam PF01654 http://pfam.xfam.org/family/PF01654 Phobius swissprot:APPC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:APPC_ECOLI PhylomeDB P26459 http://phylomedb.org/?seqid=P26459 ProteinModelPortal P26459 http://www.proteinmodelportal.org/query/uniprot/P26459 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 1658595 http://www.ncbi.nlm.nih.gov/pubmed/1658595 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19542282 http://www.ncbi.nlm.nih.gov/pubmed/19542282 PubMed 21756872 http://www.ncbi.nlm.nih.gov/pubmed/21756872 PubMed 21987791 http://www.ncbi.nlm.nih.gov/pubmed/21987791 PubMed 22843529 http://www.ncbi.nlm.nih.gov/pubmed/22843529 PubMed 8626304 http://www.ncbi.nlm.nih.gov/pubmed/8626304 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415497 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415497 RefSeq WP_000263582 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000263582 STRING 511145.b0978 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0978&targetmode=cogs STRING COG1271 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1271&targetmode=cogs UniProtKB APPC_ECOLI http://www.uniprot.org/uniprot/APPC_ECOLI UniProtKB-AC P26459 http://www.uniprot.org/uniprot/P26459 charge swissprot:APPC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:APPC_ECOLI eggNOG COG1271 http://eggnogapi.embl.de/nog_data/html/tree/COG1271 eggNOG ENOG4105C4M http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C4M epestfind swissprot:APPC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:APPC_ECOLI garnier swissprot:APPC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:APPC_ECOLI helixturnhelix swissprot:APPC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:APPC_ECOLI hmoment swissprot:APPC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:APPC_ECOLI iep swissprot:APPC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:APPC_ECOLI inforesidue swissprot:APPC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:APPC_ECOLI octanol swissprot:APPC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:APPC_ECOLI pepcoil swissprot:APPC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:APPC_ECOLI pepdigest swissprot:APPC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:APPC_ECOLI pepinfo swissprot:APPC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:APPC_ECOLI pepnet swissprot:APPC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:APPC_ECOLI pepstats swissprot:APPC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:APPC_ECOLI pepwheel swissprot:APPC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:APPC_ECOLI pepwindow swissprot:APPC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:APPC_ECOLI sigcleave swissprot:APPC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:APPC_ECOLI ## Database ID URL or Descriptions # BioGrid 4261732 6 # DISRUPTION PHENOTYPE Induction of genes regulated by PhoP, not suppressed by a dsbA deletion or 50 uM CuSO(4). {ECO:0000269|PubMed 20041203}. # EcoGene EG14383 mgrB # FUNCTION MGRB_ECOLI Represses PhoP/PhoQ signaling, possibly by binding to the periplasmic domain of PhoQ, altering its activity and that of downstream effector PhoP. PhoP-regulated transcription is redox- sensitive, being activated when the periplasm becomes more reducing (deletion of dsbA/dsbB, treatment with dithiothreitol). MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway; the 2 periplasmic Cys residues of MgrB are required for its action on PhoQ, and thus PhoP. {ECO 0000269|PubMed 20041203, ECO 0000269|PubMed 22267510}. # GO_component GO:0005886 plasma membrane; IDA:UniProtKB. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0010447 response to acidic pH; IMP:EcoCyc. # GO_process GO:0044092 negative regulation of molecular function; IMP:EcoCyc. # GO_process GO:0070298 negative regulation of phosphorelay signal transduction system; IDA:UniProtKB. # GO_process GO:0071286 cellular response to magnesium ion; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # HAMAP MF_01596 MgrB # INDUCTION MGRB_ECOLI Induced by low extracellular levels of Mg(2+) via the PhoP/PhoQ two-component regulatory system (PubMed 10464230) (Probable). In exponential phase (at protein level) (PubMed 19121005). By dithiothreitol (PubMed 22267510). {ECO 0000269|PubMed 10464230, ECO 0000269|PubMed 12813061, ECO 0000269|PubMed 17909183, ECO 0000269|PubMed 19121005, ECO 0000269|PubMed 19734316, ECO 0000269|PubMed 22267510, ECO 0000305}. # InterPro IPR020907 MgrB # Organism MGRB_ECOLI Escherichia coli (strain K12) # PATRIC 32118971 VBIEscCol129921_1903 # PIR B64944 B64944 # Pfam PF13998 MgrB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PhoP/PhoQ regulator MgrB {ECO:0000255|HAMAP-Rule MF_01596} # RefSeq NP_416340 NC_000913.3 # RefSeq WP_000714550 NZ_LN832404.1 # SIMILARITY Belongs to the MgrB family. {ECO:0000255|HAMAP- Rule MF_01596}. # SUBCELLULAR LOCATION MGRB_ECOLI Cell inner membrane {ECO 0000305|PubMed 20041203}; Single-pass membrane protein {ECO 0000305|PubMed 20041203}. # SUBUNIT MGRB_ECOLI May form homooligomers. Probably interacts with the periplasmic domain of PhoQ. {ECO 0000255|HAMAP-Rule MF_01596, ECO 0000269|PubMed 20041203}. # eggNOG ENOG410XW9Z LUCA BLAST swissprot:MGRB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MGRB_ECOLI BioCyc ECOL316407:JW1815-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1815-MONOMER BioCyc EcoCyc:G7002-MONOMER http://biocyc.org/getid?id=EcoCyc:G7002-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0700025104 http://dx.doi.org/10.1073/pnas.0700025104 DOI 10.1111/j.1365-2958.2008.06495.x http://dx.doi.org/10.1111/j.1365-2958.2008.06495.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00872-09 http://dx.doi.org/10.1128/JB.00872-09 DOI 10.1128/JB.06055-11 http://dx.doi.org/10.1128/JB.06055-11 DOI 10.1128/JB.185.13.3696-3702.2003 http://dx.doi.org/10.1128/JB.185.13.3696-3702.2003 DOI 10.1371/journal.pgen.1000788 http://dx.doi.org/10.1371/journal.pgen.1000788 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4126 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4126 EcoGene EG14383 http://www.ecogene.org/geneInfo.php?eg_id=EG14383 EnsemblBacteria AAC74896 http://www.ensemblgenomes.org/id/AAC74896 EnsemblBacteria AAC74896 http://www.ensemblgenomes.org/id/AAC74896 EnsemblBacteria BAE76539 http://www.ensemblgenomes.org/id/BAE76539 EnsemblBacteria BAE76539 http://www.ensemblgenomes.org/id/BAE76539 EnsemblBacteria BAE76539 http://www.ensemblgenomes.org/id/BAE76539 EnsemblBacteria b1826 http://www.ensemblgenomes.org/id/b1826 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0010447 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010447 GO_process GO:0044092 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044092 GO_process GO:0070298 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070298 GO_process GO:0071286 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071286 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 946351 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946351 HAMAP MF_01596 http://hamap.expasy.org/unirule/MF_01596 HOGENOM HOG000059286 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000059286&db=HOGENOM6 InterPro IPR020907 http://www.ebi.ac.uk/interpro/entry/IPR020907 KEGG_Gene ecj:JW1815 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1815 KEGG_Gene eco:b1826 http://www.genome.jp/dbget-bin/www_bget?eco:b1826 PSORT swissprot:MGRB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MGRB_ECOLI PSORT-B swissprot:MGRB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MGRB_ECOLI PSORT2 swissprot:MGRB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MGRB_ECOLI Pfam PF13998 http://pfam.xfam.org/family/PF13998 Phobius swissprot:MGRB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MGRB_ECOLI ProteinModelPortal P64512 http://www.proteinmodelportal.org/query/uniprot/P64512 PubMed 10464230 http://www.ncbi.nlm.nih.gov/pubmed/10464230 PubMed 12813061 http://www.ncbi.nlm.nih.gov/pubmed/12813061 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17909183 http://www.ncbi.nlm.nih.gov/pubmed/17909183 PubMed 19121005 http://www.ncbi.nlm.nih.gov/pubmed/19121005 PubMed 19734316 http://www.ncbi.nlm.nih.gov/pubmed/19734316 PubMed 20041203 http://www.ncbi.nlm.nih.gov/pubmed/20041203 PubMed 22267510 http://www.ncbi.nlm.nih.gov/pubmed/22267510 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416340 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416340 RefSeq WP_000714550 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000714550 STRING 511145.b1826 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1826&targetmode=cogs UniProtKB MGRB_ECOLI http://www.uniprot.org/uniprot/MGRB_ECOLI UniProtKB-AC P64512 http://www.uniprot.org/uniprot/P64512 charge swissprot:MGRB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MGRB_ECOLI eggNOG ENOG410XW9Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XW9Z epestfind swissprot:MGRB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MGRB_ECOLI garnier swissprot:MGRB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MGRB_ECOLI helixturnhelix swissprot:MGRB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MGRB_ECOLI hmoment swissprot:MGRB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MGRB_ECOLI iep swissprot:MGRB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MGRB_ECOLI inforesidue swissprot:MGRB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MGRB_ECOLI octanol swissprot:MGRB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MGRB_ECOLI pepcoil swissprot:MGRB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MGRB_ECOLI pepdigest swissprot:MGRB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MGRB_ECOLI pepinfo swissprot:MGRB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MGRB_ECOLI pepnet swissprot:MGRB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MGRB_ECOLI pepstats swissprot:MGRB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MGRB_ECOLI pepwheel swissprot:MGRB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MGRB_ECOLI pepwindow swissprot:MGRB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MGRB_ECOLI sigcleave swissprot:MGRB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MGRB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260274 5 # COFACTOR YDHV_ECOLI Name=Mo-molybdopterin; Xref=ChEBI CHEBI 71302; Evidence={ECO 0000250}; Name=tungstopterin; Xref=ChEBI CHEBI 30402; Evidence={ECO 0000250}; Note=Binds 1 Mo-molybdopterin (Mo-MPT) or 1 tungstopterin cofactor per subunit. {ECO 0000250}; # COFACTOR YDHV_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000250}; Note=Binds 1 [4Fe-4S] cluster per subunit. {ECO 0000250}; # EcoGene EG13956 ydhV # GO_function GO:0009055 electron carrier activity; IEA:InterPro. # GO_function GO:0016625 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor; IEA:InterPro. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # Gene3D 1.10.569.10 -; 1. # Gene3D 1.10.599.10 -; 1. # Gene3D 3.60.9.10 -; 1. # INDUCTION Up-regulated by the oxygen-responsive transcription factor FNR under anaerobic conditions. Repressed in the presence of nitrate or nitrite via the two-component systems NarXL and NarPQ, respectively. {ECO:0000269|PubMed 18227264}. # InterPro IPR001203 OxRdtase_Ald_Fedxn_C # InterPro IPR013983 Ald_Fedxn_OxRdtase_N # InterPro IPR013984 Ald_Fedxn_OxRdtase_2 # InterPro IPR013985 Ald_Fedxn_OxRdtase_3 # Organism YDHV_ECOLI Escherichia coli (strain K12) # PATRIC 32118652 VBIEscCol129921_1744 # PIR A64925 A64925 # Pfam PF01314 AFOR_C # Pfam PF02730 AFOR_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDHV_ECOLI Uncharacterized oxidoreductase YdhV # RefSeq NP_416188 NC_000913.3 # RefSeq WP_001273527 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB47949.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the AOR/FOR family. {ECO 0000305}. # SMART SM00790 AFOR_N # SUPFAM SSF48310 SSF48310 # SUPFAM SSF56228 SSF56228 # eggNOG COG2414 LUCA # eggNOG ENOG4105WE2 Bacteria BLAST swissprot:YDHV_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDHV_ECOLI BioCyc ECOL316407:JW5272-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5272-MONOMER BioCyc EcoCyc:G6901-MONOMER http://biocyc.org/getid?id=EcoCyc:G6901-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1099/mic.0.2007/012146-0 http://dx.doi.org/10.1099/mic.0.2007/012146-0 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U68703 http://www.ebi.ac.uk/ena/data/view/U68703 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- EchoBASE EB3714 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3714 EcoGene EG13956 http://www.ecogene.org/geneInfo.php?eg_id=EG13956 EnsemblBacteria AAC74743 http://www.ensemblgenomes.org/id/AAC74743 EnsemblBacteria AAC74743 http://www.ensemblgenomes.org/id/AAC74743 EnsemblBacteria BAE76498 http://www.ensemblgenomes.org/id/BAE76498 EnsemblBacteria BAE76498 http://www.ensemblgenomes.org/id/BAE76498 EnsemblBacteria BAE76498 http://www.ensemblgenomes.org/id/BAE76498 EnsemblBacteria b1673 http://www.ensemblgenomes.org/id/b1673 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0016625 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016625 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 1.10.569.10 http://www.cathdb.info/version/latest/superfamily/1.10.569.10 Gene3D 1.10.599.10 http://www.cathdb.info/version/latest/superfamily/1.10.599.10 Gene3D 3.60.9.10 http://www.cathdb.info/version/latest/superfamily/3.60.9.10 GeneID 948756 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948756 HOGENOM HOG000012376 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000012376&db=HOGENOM6 InParanoid P76192 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76192 IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR001203 http://www.ebi.ac.uk/interpro/entry/IPR001203 InterPro IPR013983 http://www.ebi.ac.uk/interpro/entry/IPR013983 InterPro IPR013984 http://www.ebi.ac.uk/interpro/entry/IPR013984 InterPro IPR013985 http://www.ebi.ac.uk/interpro/entry/IPR013985 KEGG_Gene ecj:JW5272 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5272 KEGG_Gene eco:b1673 http://www.genome.jp/dbget-bin/www_bget?eco:b1673 OMA EYNSIPW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EYNSIPW PSORT swissprot:YDHV_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDHV_ECOLI PSORT-B swissprot:YDHV_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDHV_ECOLI PSORT2 swissprot:YDHV_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDHV_ECOLI Pfam PF01314 http://pfam.xfam.org/family/PF01314 Pfam PF02730 http://pfam.xfam.org/family/PF02730 Phobius swissprot:YDHV_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDHV_ECOLI PhylomeDB P76192 http://phylomedb.org/?seqid=P76192 ProteinModelPortal P76192 http://www.proteinmodelportal.org/query/uniprot/P76192 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18227264 http://www.ncbi.nlm.nih.gov/pubmed/18227264 PubMed 9023191 http://www.ncbi.nlm.nih.gov/pubmed/9023191 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416188 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416188 RefSeq WP_001273527 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001273527 SMART SM00790 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00790 SMR P76192 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76192 STRING 511145.b1673 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1673&targetmode=cogs SUPFAM SSF48310 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48310 SUPFAM SSF56228 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56228 UniProtKB YDHV_ECOLI http://www.uniprot.org/uniprot/YDHV_ECOLI UniProtKB-AC P76192 http://www.uniprot.org/uniprot/P76192 charge swissprot:YDHV_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDHV_ECOLI eggNOG COG2414 http://eggnogapi.embl.de/nog_data/html/tree/COG2414 eggNOG ENOG4105WE2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105WE2 epestfind swissprot:YDHV_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDHV_ECOLI garnier swissprot:YDHV_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDHV_ECOLI helixturnhelix swissprot:YDHV_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDHV_ECOLI hmoment swissprot:YDHV_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDHV_ECOLI iep swissprot:YDHV_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDHV_ECOLI inforesidue swissprot:YDHV_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDHV_ECOLI octanol swissprot:YDHV_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDHV_ECOLI pepcoil swissprot:YDHV_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDHV_ECOLI pepdigest swissprot:YDHV_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDHV_ECOLI pepinfo swissprot:YDHV_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDHV_ECOLI pepnet swissprot:YDHV_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDHV_ECOLI pepstats swissprot:YDHV_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDHV_ECOLI pepwheel swissprot:YDHV_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDHV_ECOLI pepwindow swissprot:YDHV_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDHV_ECOLI sigcleave swissprot:YDHV_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDHV_ECOLI ## Database ID URL or Descriptions # AltName BORD_ECOLI Lipoprotein Bor homolog from lambdoid prophage DLP12 # BioGrid 4263499 8 # EcoGene EG13637 borD # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0009279 cell outer membrane; IEA:InterPro. # GO_process GO:0071286 cellular response to magnesium ion; IEP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0008150 biological_process # InterPro IPR010438 Lambda_Bor # MISCELLANEOUS BORD_ECOLI Encoded by the cryptic lambdoid prophage DLP12. # Organism BORD_ECOLI Escherichia coli (strain K12) # PATRIC 32116280 VBIEscCol129921_0580 # PIR C64788 C64788 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF06291 Lambda_Bor # ProDom PD020173 Lambda_Bor # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Prophage lipoprotein Bor homolog {ECO 0000305} # RefSeq NP_415089 NC_000913.3 # RefSeq WP_000738500 NZ_CP014272.1 # SIMILARITY Belongs to the lambda phage bor family. {ECO 0000305}. # SUBCELLULAR LOCATION BORD_ECOLI Cell membrane {ECO 0000305}; Lipid-anchor {ECO 0000305}. # eggNOG ENOG4105QYK Bacteria # eggNOG ENOG4111UF1 LUCA BLAST swissprot:BORD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BORD_ECOLI BioCyc ECOL316407:JW0546-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0546-MONOMER BioCyc EcoCyc:G6312-MONOMER http://biocyc.org/getid?id=EcoCyc:G6312-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB3401 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3401 EcoGene EG13637 http://www.ecogene.org/geneInfo.php?eg_id=EG13637 EnsemblBacteria AAC73658 http://www.ensemblgenomes.org/id/AAC73658 EnsemblBacteria AAC73658 http://www.ensemblgenomes.org/id/AAC73658 EnsemblBacteria BAE76333 http://www.ensemblgenomes.org/id/BAE76333 EnsemblBacteria BAE76333 http://www.ensemblgenomes.org/id/BAE76333 EnsemblBacteria BAE76333 http://www.ensemblgenomes.org/id/BAE76333 EnsemblBacteria b0557 http://www.ensemblgenomes.org/id/b0557 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_process GO:0071286 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071286 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 948980 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948980 HOGENOM HOG000119353 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000119353&db=HOGENOM6 InParanoid P77330 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77330 InterPro IPR010438 http://www.ebi.ac.uk/interpro/entry/IPR010438 KEGG_Gene ecj:JW0546 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0546 KEGG_Gene eco:b0557 http://www.genome.jp/dbget-bin/www_bget?eco:b0557 PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:BORD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BORD_ECOLI PSORT-B swissprot:BORD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BORD_ECOLI PSORT2 swissprot:BORD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BORD_ECOLI Pfam PF06291 http://pfam.xfam.org/family/PF06291 Phobius swissprot:BORD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BORD_ECOLI ProteinModelPortal P77330 http://www.proteinmodelportal.org/query/uniprot/P77330 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415089 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415089 RefSeq WP_000738500 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000738500 STRING 511145.b0557 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0557&targetmode=cogs UniProtKB BORD_ECOLI http://www.uniprot.org/uniprot/BORD_ECOLI UniProtKB-AC P77330 http://www.uniprot.org/uniprot/P77330 charge swissprot:BORD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BORD_ECOLI eggNOG ENOG4105QYK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105QYK eggNOG ENOG4111UF1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111UF1 epestfind swissprot:BORD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BORD_ECOLI garnier swissprot:BORD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BORD_ECOLI helixturnhelix swissprot:BORD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BORD_ECOLI hmoment swissprot:BORD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BORD_ECOLI iep swissprot:BORD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BORD_ECOLI inforesidue swissprot:BORD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BORD_ECOLI octanol swissprot:BORD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BORD_ECOLI pepcoil swissprot:BORD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BORD_ECOLI pepdigest swissprot:BORD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BORD_ECOLI pepinfo swissprot:BORD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BORD_ECOLI pepnet swissprot:BORD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BORD_ECOLI pepstats swissprot:BORD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BORD_ECOLI pepwheel swissprot:BORD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BORD_ECOLI pepwindow swissprot:BORD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BORD_ECOLI sigcleave swissprot:BORD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BORD_ECOLI ## Database ID URL or Descriptions # BioGrid 4259832 17 # EcoGene EG11093 yaiA # IntAct P0AAN5 13 # InterPro IPR032303 YaiA # Organism YAIA_ECOLI Escherichia coli (strain K12) # PATRIC 32115919 VBIEscCol129921_0401 # PDB 2KVT NMR; -; A=1-63 # PIR B25197 QQECLM # Pfam PF16362 YaiA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAIA_ECOLI Uncharacterized protein YaiA # RefSeq NP_414923 NC_000913.3 # RefSeq WP_001142439 NZ_LN832404.1 # eggNOG ENOG4105SS3 Bacteria # eggNOG ENOG41121PA LUCA BLAST swissprot:YAIA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAIA_ECOLI BioCyc ECOL316407:JW0380-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0380-MONOMER BioCyc EcoCyc:EG11093-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11093-MONOMER DIP DIP-48130N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48130N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M13045 http://www.ebi.ac.uk/ena/data/view/M13045 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB1085 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1085 EcoGene EG11093 http://www.ecogene.org/geneInfo.php?eg_id=EG11093 EnsemblBacteria AAC73492 http://www.ensemblgenomes.org/id/AAC73492 EnsemblBacteria AAC73492 http://www.ensemblgenomes.org/id/AAC73492 EnsemblBacteria BAE76170 http://www.ensemblgenomes.org/id/BAE76170 EnsemblBacteria BAE76170 http://www.ensemblgenomes.org/id/BAE76170 EnsemblBacteria BAE76170 http://www.ensemblgenomes.org/id/BAE76170 EnsemblBacteria b0389 http://www.ensemblgenomes.org/id/b0389 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945043 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945043 HOGENOM HOG000267832 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267832&db=HOGENOM6 IntAct P0AAN5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAN5* InterPro IPR032303 http://www.ebi.ac.uk/interpro/entry/IPR032303 KEGG_Gene ecj:JW0380 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0380 KEGG_Gene eco:b0389 http://www.genome.jp/dbget-bin/www_bget?eco:b0389 OMA SEHETEQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SEHETEQ PDB 2KVT http://www.ebi.ac.uk/pdbe-srv/view/entry/2KVT PDBsum 2KVT http://www.ebi.ac.uk/pdbsum/2KVT PSORT swissprot:YAIA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAIA_ECOLI PSORT-B swissprot:YAIA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAIA_ECOLI PSORT2 swissprot:YAIA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAIA_ECOLI Pfam PF16362 http://pfam.xfam.org/family/PF16362 Phobius swissprot:YAIA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAIA_ECOLI ProteinModelPortal P0AAN5 http://www.proteinmodelportal.org/query/uniprot/P0AAN5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3001025 http://www.ncbi.nlm.nih.gov/pubmed/3001025 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414923 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414923 RefSeq WP_001142439 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001142439 SMR P0AAN5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAN5 STRING 511145.b0389 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0389&targetmode=cogs UniProtKB YAIA_ECOLI http://www.uniprot.org/uniprot/YAIA_ECOLI UniProtKB-AC P0AAN5 http://www.uniprot.org/uniprot/P0AAN5 charge swissprot:YAIA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAIA_ECOLI eggNOG ENOG4105SS3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105SS3 eggNOG ENOG41121PA http://eggnogapi.embl.de/nog_data/html/tree/ENOG41121PA epestfind swissprot:YAIA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAIA_ECOLI garnier swissprot:YAIA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAIA_ECOLI helixturnhelix swissprot:YAIA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAIA_ECOLI hmoment swissprot:YAIA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAIA_ECOLI iep swissprot:YAIA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAIA_ECOLI inforesidue swissprot:YAIA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAIA_ECOLI octanol swissprot:YAIA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAIA_ECOLI pepcoil swissprot:YAIA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAIA_ECOLI pepdigest swissprot:YAIA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAIA_ECOLI pepinfo swissprot:YAIA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAIA_ECOLI pepnet swissprot:YAIA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAIA_ECOLI pepstats swissprot:YAIA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAIA_ECOLI pepwheel swissprot:YAIA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAIA_ECOLI pepwindow swissprot:YAIA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAIA_ECOLI sigcleave swissprot:YAIA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAIA_ECOLI ## Database ID URL or Descriptions # EcoGene EG10292 fecR # FUNCTION FECR_ECOLI Regulation of iron dicitrate transport. In the absence of citrate FecR inactivates fecI. FecR is probably a sensor that recognizes iron dicitrate in the periplasm. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_process GO:0006811 ion transport; IEA:UniProtKB-KW. # GO_process GO:0050896 response to stimulus; IEA:UniProtKB-KW. # GO_process GO:0055072 iron ion homeostasis; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # GOslim_process GO:0042592 homeostatic process # INDUCTION Induced by hydroxyurea. {ECO:0000269|PubMed 20005847}. # IntAct P23485 3 # InterPro IPR006860 FecR # InterPro IPR012373 Ferrdict_sens_TM # InterPro IPR032508 FecR_C # InterPro IPR032623 FecR_N # Organism FECR_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30273 PTHR30273 # PATRIC 32124163 VBIEscCol129921_4425 # PIR B37804 B37804 # PIRSF PIRSF018266 FecR # Pfam PF04773 FecR # Pfam PF16220 DUF4880 # Pfam PF16344 DUF4974 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FECR_ECOLI Protein FecR # RefSeq NP_418712 NC_000913.3 # RefSeq WP_001068910 NZ_LN832404.1 # SUBCELLULAR LOCATION FECR_ECOLI Periplasm. # eggNOG COG3712 LUCA # eggNOG ENOG4108S3W Bacteria BLAST swissprot:FECR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FECR_ECOLI BioCyc ECOL316407:JW4252-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4252-MONOMER BioCyc EcoCyc:EG10292-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10292-MONOMER COG COG3712 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3712 DIP DIP-9589N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9589N DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M63115 http://www.ebi.ac.uk/ena/data/view/M63115 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB0288 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0288 EcoGene EG10292 http://www.ecogene.org/geneInfo.php?eg_id=EG10292 EnsemblBacteria AAC77248 http://www.ensemblgenomes.org/id/AAC77248 EnsemblBacteria AAC77248 http://www.ensemblgenomes.org/id/AAC77248 EnsemblBacteria BAE78283 http://www.ensemblgenomes.org/id/BAE78283 EnsemblBacteria BAE78283 http://www.ensemblgenomes.org/id/BAE78283 EnsemblBacteria BAE78283 http://www.ensemblgenomes.org/id/BAE78283 EnsemblBacteria b4292 http://www.ensemblgenomes.org/id/b4292 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_process GO:0006811 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811 GO_process GO:0050896 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050896 GO_process GO:0055072 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055072 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GeneID 949104 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949104 HOGENOM HOG000258943 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000258943&db=HOGENOM6 InParanoid P23485 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23485 IntAct P23485 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P23485* InterPro IPR006860 http://www.ebi.ac.uk/interpro/entry/IPR006860 InterPro IPR012373 http://www.ebi.ac.uk/interpro/entry/IPR012373 InterPro IPR032508 http://www.ebi.ac.uk/interpro/entry/IPR032508 InterPro IPR032623 http://www.ebi.ac.uk/interpro/entry/IPR032623 KEGG_Gene ecj:JW4252 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4252 KEGG_Gene eco:b4292 http://www.genome.jp/dbget-bin/www_bget?eco:b4292 KEGG_Orthology KO:K07165 http://www.genome.jp/dbget-bin/www_bget?KO:K07165 MINT MINT-119295 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-119295 OMA AWERTCK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AWERTCK PANTHER PTHR30273 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30273 PSORT swissprot:FECR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FECR_ECOLI PSORT-B swissprot:FECR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FECR_ECOLI PSORT2 swissprot:FECR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FECR_ECOLI Pfam PF04773 http://pfam.xfam.org/family/PF04773 Pfam PF16220 http://pfam.xfam.org/family/PF16220 Pfam PF16344 http://pfam.xfam.org/family/PF16344 Phobius swissprot:FECR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FECR_ECOLI PhylomeDB P23485 http://phylomedb.org/?seqid=P23485 ProteinModelPortal P23485 http://www.proteinmodelportal.org/query/uniprot/P23485 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 2254251 http://www.ncbi.nlm.nih.gov/pubmed/2254251 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418712 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418712 RefSeq WP_001068910 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001068910 STRING 511145.b4292 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4292&targetmode=cogs STRING COG3712 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3712&targetmode=cogs UniProtKB FECR_ECOLI http://www.uniprot.org/uniprot/FECR_ECOLI UniProtKB-AC P23485 http://www.uniprot.org/uniprot/P23485 charge swissprot:FECR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FECR_ECOLI eggNOG COG3712 http://eggnogapi.embl.de/nog_data/html/tree/COG3712 eggNOG ENOG4108S3W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108S3W epestfind swissprot:FECR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FECR_ECOLI garnier swissprot:FECR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FECR_ECOLI helixturnhelix swissprot:FECR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FECR_ECOLI hmoment swissprot:FECR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FECR_ECOLI iep swissprot:FECR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FECR_ECOLI inforesidue swissprot:FECR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FECR_ECOLI octanol swissprot:FECR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FECR_ECOLI pepcoil swissprot:FECR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FECR_ECOLI pepdigest swissprot:FECR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FECR_ECOLI pepinfo swissprot:FECR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FECR_ECOLI pepnet swissprot:FECR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FECR_ECOLI pepstats swissprot:FECR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FECR_ECOLI pepwheel swissprot:FECR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FECR_ECOLI pepwindow swissprot:FECR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FECR_ECOLI sigcleave swissprot:FECR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FECR_ECOLI ## Database ID URL or Descriptions # AltName AZOR_ECOLI Azo-dye reductase # AltName AZOR_ECOLI FMN-dependent NADH-azo compound oxidoreductase # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters KM=17.9 uM for methyl red; KM=31.6 uM for NADH; # BRENDA 1.7.1 2026 # BioGrid 4261518 6 # CAUTION Was originally thought to be an ACP phosphodiesterase. {ECO:0000305|PubMed 2168383}. # COFACTOR AZOR_ECOLI Name=FMN; Xref=ChEBI CHEBI 58210; Evidence={ECO 0000269|PubMed 11583992}; Note=Binds 1 FMN per subunit. {ECO 0000269|PubMed 11583992}; # DrugBank DB02325 Isopropyl Alcohol # EcoGene EG12695 azoR # FUNCTION AZOR_ECOLI Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity. The enzyme can reduce ethyl red and methyl red, but is not able to convert sulfonated azo dyes. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008752 FMN reductase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0009055 electron carrier activity; IEA:UniProtKB-HAMAP. # GO_function GO:0010181 FMN binding; IDA:EcoCyc. # GO_function GO:0016652 oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor; IEA:UniProtKB-HAMAP. # GO_function GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; IDA:EcoCyc. # GO_function GO:0050446 azobenzene reductase activity; IDA:EcoCyc. # GO_process GO:0006979 response to oxidative stress; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # Gene3D 3.40.50.360 -; 1. # HAMAP MF_01216 Azoreductase_type1 # InterPro IPR003680 Flavodoxin_fold # InterPro IPR023048 NADH-azoreductase_FMN-depdnt # InterPro IPR029039 Flavoprotein-like_dom # KEGG_Brite ko01000 Enzymes # MISCELLANEOUS AZOR_ECOLI The stoichiometry implies that 2 cycles of the ping-pong mechanism are required for the cleavage. # Organism AZOR_ECOLI Escherichia coli (strain K12) # PATRIC 32118110 VBIEscCol129921_1475 # PDB 1TIK X-ray; 2.30 A; A=2-201 # PDB 1V4B X-ray; 1.80 A; A=2-201 # PDB 2D5I X-ray; 2.20 A; A=2-201 # PDB 2Z98 X-ray; 1.40 A; A=2-201 # PDB 2Z9B X-ray; 1.70 A; A=2-201 # PDB 2Z9C X-ray; 2.30 A; A=2-201 # PDB 2Z9D X-ray; 2.10 A; A/B=2-201 # PIR G64892 G64892 # Pfam PF02525 Flavodoxin_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AZOR_ECOLI FMN-dependent NADH-azoreductase # RefSeq NP_415930 NC_000913.3 # RefSeq WP_000048950 NZ_LN832404.1 # SIMILARITY Belongs to the azoreductase type 1 family. {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 11583992, ECO:0000269|Ref.10}. # SUPFAM SSF52218 SSF52218 # eggNOG COG1182 LUCA # eggNOG ENOG4108V3G Bacteria BLAST swissprot:AZOR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AZOR_ECOLI BioCyc ECOL316407:JW1409-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1409-MONOMER BioCyc EcoCyc:G6731-MONOMER http://biocyc.org/getid?id=EcoCyc:G6731-MONOMER BioCyc MetaCyc:G6731-MONOMER http://biocyc.org/getid?id=MetaCyc:G6731-MONOMER COG COG1182 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1182 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M104483200 http://dx.doi.org/10.1074/jbc.M104483200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/23.4.595 http://dx.doi.org/10.1093/nar/23.4.595 DOI 10.1107/S1744309105007918 http://dx.doi.org/10.1107/S1744309105007918 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB02325 http://www.drugbank.ca/drugs/DB02325 EC_number EC:1.7.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.7.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D42105 http://www.ebi.ac.uk/ena/data/view/D42105 EMBL D85081 http://www.ebi.ac.uk/ena/data/view/D85081 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.7.-.- http://enzyme.expasy.org/EC/1.7.-.- EchoBASE EB2558 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2558 EcoGene EG12695 http://www.ecogene.org/geneInfo.php?eg_id=EG12695 EnsemblBacteria AAC74494 http://www.ensemblgenomes.org/id/AAC74494 EnsemblBacteria AAC74494 http://www.ensemblgenomes.org/id/AAC74494 EnsemblBacteria BAA15024 http://www.ensemblgenomes.org/id/BAA15024 EnsemblBacteria BAA15024 http://www.ensemblgenomes.org/id/BAA15024 EnsemblBacteria BAA15024 http://www.ensemblgenomes.org/id/BAA15024 EnsemblBacteria b1412 http://www.ensemblgenomes.org/id/b1412 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008752 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008752 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0010181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010181 GO_function GO:0016652 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016652 GO_function GO:0016655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016655 GO_function GO:0050446 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050446 GO_process GO:0006979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.40.50.360 http://www.cathdb.info/version/latest/superfamily/3.40.50.360 GeneID 947569 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947569 HAMAP MF_01216 http://hamap.expasy.org/unirule/MF_01216 HOGENOM HOG000247892 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000247892&db=HOGENOM6 InParanoid P41407 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P41407 IntEnz 1.7 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.7 InterPro IPR003680 http://www.ebi.ac.uk/interpro/entry/IPR003680 InterPro IPR023048 http://www.ebi.ac.uk/interpro/entry/IPR023048 InterPro IPR029039 http://www.ebi.ac.uk/interpro/entry/IPR029039 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1409 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1409 KEGG_Gene eco:b1412 http://www.genome.jp/dbget-bin/www_bget?eco:b1412 KEGG_Orthology KO:K01118 http://www.genome.jp/dbget-bin/www_bget?KO:K01118 OMA WMKPEEQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WMKPEEQ PDB 1TIK http://www.ebi.ac.uk/pdbe-srv/view/entry/1TIK PDB 1V4B http://www.ebi.ac.uk/pdbe-srv/view/entry/1V4B PDB 2D5I http://www.ebi.ac.uk/pdbe-srv/view/entry/2D5I PDB 2Z98 http://www.ebi.ac.uk/pdbe-srv/view/entry/2Z98 PDB 2Z9B http://www.ebi.ac.uk/pdbe-srv/view/entry/2Z9B PDB 2Z9C http://www.ebi.ac.uk/pdbe-srv/view/entry/2Z9C PDB 2Z9D http://www.ebi.ac.uk/pdbe-srv/view/entry/2Z9D PDBsum 1TIK http://www.ebi.ac.uk/pdbsum/1TIK PDBsum 1V4B http://www.ebi.ac.uk/pdbsum/1V4B PDBsum 2D5I http://www.ebi.ac.uk/pdbsum/2D5I PDBsum 2Z98 http://www.ebi.ac.uk/pdbsum/2Z98 PDBsum 2Z9B http://www.ebi.ac.uk/pdbsum/2Z9B PDBsum 2Z9C http://www.ebi.ac.uk/pdbsum/2Z9C PDBsum 2Z9D http://www.ebi.ac.uk/pdbsum/2Z9D PSORT swissprot:AZOR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AZOR_ECOLI PSORT-B swissprot:AZOR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AZOR_ECOLI PSORT2 swissprot:AZOR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AZOR_ECOLI Pfam PF02525 http://pfam.xfam.org/family/PF02525 Phobius swissprot:AZOR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AZOR_ECOLI PhylomeDB P41407 http://phylomedb.org/?seqid=P41407 ProteinModelPortal P41407 http://www.proteinmodelportal.org/query/uniprot/P41407 PubMed 11583992 http://www.ncbi.nlm.nih.gov/pubmed/11583992 PubMed 16511052 http://www.ncbi.nlm.nih.gov/pubmed/16511052 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2168383 http://www.ncbi.nlm.nih.gov/pubmed/2168383 PubMed 7899078 http://www.ncbi.nlm.nih.gov/pubmed/7899078 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415930 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415930 RefSeq WP_000048950 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000048950 SMR P41407 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P41407 STRING 511145.b1412 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1412&targetmode=cogs STRING COG1182 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1182&targetmode=cogs SUPFAM SSF52218 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52218 UniProtKB AZOR_ECOLI http://www.uniprot.org/uniprot/AZOR_ECOLI UniProtKB-AC P41407 http://www.uniprot.org/uniprot/P41407 charge swissprot:AZOR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AZOR_ECOLI eggNOG COG1182 http://eggnogapi.embl.de/nog_data/html/tree/COG1182 eggNOG ENOG4108V3G http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108V3G epestfind swissprot:AZOR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AZOR_ECOLI garnier swissprot:AZOR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AZOR_ECOLI helixturnhelix swissprot:AZOR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AZOR_ECOLI hmoment swissprot:AZOR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AZOR_ECOLI iep swissprot:AZOR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AZOR_ECOLI inforesidue swissprot:AZOR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AZOR_ECOLI octanol swissprot:AZOR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AZOR_ECOLI pepcoil swissprot:AZOR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AZOR_ECOLI pepdigest swissprot:AZOR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AZOR_ECOLI pepinfo swissprot:AZOR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AZOR_ECOLI pepnet swissprot:AZOR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AZOR_ECOLI pepstats swissprot:AZOR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AZOR_ECOLI pepwheel swissprot:AZOR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AZOR_ECOLI pepwindow swissprot:AZOR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AZOR_ECOLI sigcleave swissprot:AZOR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AZOR_ECOLI ## Database ID URL or Descriptions # AltName Dihydrofolate reductase {ECO:0000303|PubMed 14617668} # BIOPHYSICOCHEMICAL PROPERTIES FOLM_ECOLI Kinetic parameters KM=9.5 uM for 7,8-dihydrofolate (at pH 6.0) {ECO 0000269|PubMed 14617668}; KM=147 uM for 7,8-dihydromonapterin (at pH 6.0) {ECO 0000269|PubMed 19897652}; KM=1.9 uM for NADPH (at pH 6.0) {ECO 0000269|PubMed 14617668}; Vmax=0.083 umol/min/mg enzyme with 7,8-dihydrofolate as substrate {ECO 0000269|PubMed 14617668}; Vmax=5.99 umol/min/mg enzyme with 7,8-dihydromoapterin as substrate {ECO 0000269|PubMed 19897652}; pH dependence Optimum pH is 4.7. {ECO 0000269|PubMed 14617668}; # BioGrid 4262123 119 # CATALYTIC ACTIVITY 5,6,7,8-tetrahydrofolate + NADP(+) = 7,8- dihydrofolate + NADPH. {ECO:0000269|PubMed 14617668}. # CATALYTIC ACTIVITY 5,6,7,8-tetrahydromonapterin + NADP(+) = 7,8- dihydromonapterin + NADPH. {ECO:0000269|PubMed 19897652}. # ENZYME REGULATION Inhibited by methotrexate. {ECO:0000269|PubMed 14617668}. # EcoGene EG13189 folM # FUNCTION FOLM_ECOLI Catalyzes the reduction of dihydromonapterin to tetrahydromonapterin. Also has lower activity with dihydrofolate. {ECO 0000269|PubMed 19897652}. # GO_function GO:0004146 dihydrofolate reductase activity; IEA:UniProtKB-EC. # GO_function GO:0071172 dihydromonapterin reductase activity; IDA:EcoCyc. # GO_process GO:0006730 one-carbon metabolic process; IEA:UniProtKB-KW. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.720 -; 1. # IntAct P0AFS3 5 # InterPro IPR002347 SDR_fam # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR020904 Sc_DH/Rdtase_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00670 One carbon pool by folate # KEGG_Pathway ko00790 Folate biosynthesis # Organism FOLM_ECOLI Escherichia coli (strain K12) # PANTHER PTHR24322 PTHR24322; 2 # PATRIC 32118514 VBIEscCol129921_1677 # PIR H64916 H64916 # PRINTS PR00081 GDHRDH # PROSITE PS00061 ADH_SHORT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Dihydromonapterin reductase {ECO:0000303|PubMed 19897652} # RefSeq NP_416123 NC_000913.3 # RefSeq WP_000520804 NZ_LN832404.1 # SIMILARITY Belongs to the short-chain dehydrogenases/reductases (SDR) family. FolM subfamily. {ECO 0000305}. # SUPFAM SSF51735 SSF51735 # eggNOG COG1028 LUCA # eggNOG ENOG410642E Bacteria BLAST swissprot:FOLM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FOLM_ECOLI BioCyc ECOL316407:JW1598-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1598-MONOMER BioCyc EcoCyc:G6862-MONOMER http://biocyc.org/getid?id=EcoCyc:G6862-MONOMER BioCyc MetaCyc:G6862-MONOMER http://biocyc.org/getid?id=MetaCyc:G6862-MONOMER COG COG1028 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1028 DIP DIP-47981N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47981N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01198-09 http://dx.doi.org/10.1128/JB.01198-09 DOI 10.1128/JB.185.23.7015-7018.2003 http://dx.doi.org/10.1128/JB.185.23.7015-7018.2003 EC_number EC:1.5.1.- {ECO:0000269|PubMed:19897652} http://www.genome.jp/dbget-bin/www_bget?EC:1.5.1.- {ECO:0000269|PubMed:19897652} EC_number EC:1.5.1.3 {ECO:0000269|PubMed:14617668} http://www.genome.jp/dbget-bin/www_bget?EC:1.5.1.3 {ECO:0000269|PubMed:14617668} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U41101 http://www.ebi.ac.uk/ena/data/view/U41101 ENZYME 1.5.1.- {ECO:0000269|PubMed:19897652} http://enzyme.expasy.org/EC/1.5.1.- {ECO:0000269|PubMed:19897652} ENZYME 1.5.1.3 {ECO:0000269|PubMed:14617668} http://enzyme.expasy.org/EC/1.5.1.3 {ECO:0000269|PubMed:14617668} EchoBASE EB2981 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2981 EcoGene EG13189 http://www.ecogene.org/geneInfo.php?eg_id=EG13189 EnsemblBacteria AAC74678 http://www.ensemblgenomes.org/id/AAC74678 EnsemblBacteria AAC74678 http://www.ensemblgenomes.org/id/AAC74678 EnsemblBacteria BAA15344 http://www.ensemblgenomes.org/id/BAA15344 EnsemblBacteria BAA15344 http://www.ensemblgenomes.org/id/BAA15344 EnsemblBacteria BAA15344 http://www.ensemblgenomes.org/id/BAA15344 EnsemblBacteria b1606 http://www.ensemblgenomes.org/id/b1606 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004146 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004146 GO_function GO:0071172 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071172 GO_process GO:0006730 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006730 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 949096 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949096 InParanoid P0AFS3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFS3 IntAct P0AFS3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFS3* IntEnz 1.5.1.- {ECO:0000269|PubMed:19897652} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.5.1.- {ECO:0000269|PubMed:19897652} IntEnz 1.5.1.3 {ECO:0000269|PubMed:14617668} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.5.1.3 {ECO:0000269|PubMed:14617668} InterPro IPR002347 http://www.ebi.ac.uk/interpro/entry/IPR002347 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR020904 http://www.ebi.ac.uk/interpro/entry/IPR020904 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1598 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1598 KEGG_Gene eco:b1606 http://www.genome.jp/dbget-bin/www_bget?eco:b1606 KEGG_Orthology KO:K13938 http://www.genome.jp/dbget-bin/www_bget?KO:K13938 KEGG_Pathway ko00670 http://www.genome.jp/kegg-bin/show_pathway?ko00670 KEGG_Pathway ko00790 http://www.genome.jp/kegg-bin/show_pathway?ko00790 KEGG_Reaction rn:R00936 http://www.genome.jp/dbget-bin/www_bget?rn:R00936 KEGG_Reaction rn:R00939 http://www.genome.jp/dbget-bin/www_bget?rn:R00939 OMA PALLMFN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PALLMFN PANTHER PTHR24322 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24322 PRINTS PR00081 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00081 PROSITE PS00061 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00061 PSORT swissprot:FOLM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FOLM_ECOLI PSORT-B swissprot:FOLM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FOLM_ECOLI PSORT2 swissprot:FOLM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FOLM_ECOLI Phobius swissprot:FOLM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FOLM_ECOLI PhylomeDB P0AFS3 http://phylomedb.org/?seqid=P0AFS3 ProteinModelPortal P0AFS3 http://www.proteinmodelportal.org/query/uniprot/P0AFS3 PubMed 14617668 http://www.ncbi.nlm.nih.gov/pubmed/14617668 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19897652 http://www.ncbi.nlm.nih.gov/pubmed/19897652 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416123 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416123 RefSeq WP_000520804 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000520804 SMR P0AFS3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFS3 STRING 511145.b1606 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1606&targetmode=cogs STRING COG1028 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1028&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB FOLM_ECOLI http://www.uniprot.org/uniprot/FOLM_ECOLI UniProtKB-AC P0AFS3 http://www.uniprot.org/uniprot/P0AFS3 charge swissprot:FOLM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FOLM_ECOLI eggNOG COG1028 http://eggnogapi.embl.de/nog_data/html/tree/COG1028 eggNOG ENOG410642E http://eggnogapi.embl.de/nog_data/html/tree/ENOG410642E epestfind swissprot:FOLM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FOLM_ECOLI garnier swissprot:FOLM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FOLM_ECOLI helixturnhelix swissprot:FOLM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FOLM_ECOLI hmoment swissprot:FOLM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FOLM_ECOLI iep swissprot:FOLM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FOLM_ECOLI inforesidue swissprot:FOLM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FOLM_ECOLI octanol swissprot:FOLM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FOLM_ECOLI pepcoil swissprot:FOLM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FOLM_ECOLI pepdigest swissprot:FOLM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FOLM_ECOLI pepinfo swissprot:FOLM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FOLM_ECOLI pepnet swissprot:FOLM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FOLM_ECOLI pepstats swissprot:FOLM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FOLM_ECOLI pepwheel swissprot:FOLM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FOLM_ECOLI pepwindow swissprot:FOLM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FOLM_ECOLI sigcleave swissprot:FOLM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FOLM_ECOLI ## Database ID URL or Descriptions # CDD cd06174 MFS # EcoGene EG11754 setA # FUNCTION SETA_ECOLI Involved in the efflux of sugars. The physiological role may be the detoxification of non-metabolizable sugar analogs. Can transport IPTG, lactose and glucose. Has broad substrate specificity, with preferences for glucosides or galactosides with alkyl or aryl substituents. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:EcoliWiki. # GO_component GO:0016021 integral component of membrane; IDA:EcoCyc. # GO_function GO:0015542 sugar efflux transmembrane transporter activity; IDA:EcoliWiki. # GO_process GO:0015758 glucose transport; IDA:EcoliWiki. # GO_process GO:0015767 lactose transport; IDA:EcoliWiki. # GO_process GO:0036448 cellular response to glucose-phosphate stress; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0006950 response to stress # InterPro IPR004750 Sugar_efflux # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # KEGG_Brite ko02000 Transporters # Organism SETA_ECOLI Escherichia coli (strain K12) # PATRIC 32115243 VBIEscCol129921_0073 # PIR F64728 F64728 # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SETA_ECOLI Sugar efflux transporter A # RefSeq WP_000637847 NZ_LN832404.1 # RefSeq YP_025293 NC_000913.3 # SIMILARITY Belongs to the major facilitator superfamily. Set transporter family. {ECO 0000305}. # SUBCELLULAR LOCATION SETA_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.20 the major facilitator superfamily (mfs) # TIGRFAMs TIGR00899 2A0120 # eggNOG ENOG4105S8Q Bacteria # eggNOG ENOG410XTE9 LUCA BLAST swissprot:SETA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SETA_ECOLI BioCyc ECOL316407:JW0069-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0069-MONOMER BioCyc EcoCyc:B0070-MONOMER http://biocyc.org/getid?id=EcoCyc:B0070-MONOMER BioCyc MetaCyc:B0070-MONOMER http://biocyc.org/getid?id=MetaCyc:B0070-MONOMER COG COG0477 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0477 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1999.01321.x http://dx.doi.org/10.1046/j.1365-2958.1999.01321.x DOI 10.1074/jbc.274.33.22977 http://dx.doi.org/10.1074/jbc.274.33.22977 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1704 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1704 EcoGene EG11754 http://www.ecogene.org/geneInfo.php?eg_id=EG11754 EnsemblBacteria AAT48123 http://www.ensemblgenomes.org/id/AAT48123 EnsemblBacteria AAT48123 http://www.ensemblgenomes.org/id/AAT48123 EnsemblBacteria BAB96639 http://www.ensemblgenomes.org/id/BAB96639 EnsemblBacteria BAB96639 http://www.ensemblgenomes.org/id/BAB96639 EnsemblBacteria BAB96639 http://www.ensemblgenomes.org/id/BAB96639 EnsemblBacteria b0070 http://www.ensemblgenomes.org/id/b0070 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015542 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015542 GO_process GO:0015758 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015758 GO_process GO:0015767 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015767 GO_process GO:0036448 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036448 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 944793 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944793 HOGENOM HOG000281090 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000281090&db=HOGENOM6 InParanoid P31675 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31675 InterPro IPR004750 http://www.ebi.ac.uk/interpro/entry/IPR004750 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0069 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0069 KEGG_Gene eco:b0070 http://www.genome.jp/dbget-bin/www_bget?eco:b0070 KEGG_Orthology KO:K03291 http://www.genome.jp/dbget-bin/www_bget?KO:K03291 OMA QPFWVGL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QPFWVGL PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:SETA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SETA_ECOLI PSORT-B swissprot:SETA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SETA_ECOLI PSORT2 swissprot:SETA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SETA_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:SETA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SETA_ECOLI PhylomeDB P31675 http://phylomedb.org/?seqid=P31675 ProteinModelPortal P31675 http://www.proteinmodelportal.org/query/uniprot/P31675 PubMed 10209755 http://www.ncbi.nlm.nih.gov/pubmed/10209755 PubMed 10438463 http://www.ncbi.nlm.nih.gov/pubmed/10438463 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000637847 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000637847 RefSeq YP_025293 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_025293 STRING 511145.b0070 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0070&targetmode=cogs STRING COG0477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0477&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.20 http://www.tcdb.org/search/result.php?tc=2.A.1.20 TIGRFAMs TIGR00899 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00899 UniProtKB SETA_ECOLI http://www.uniprot.org/uniprot/SETA_ECOLI UniProtKB-AC P31675 http://www.uniprot.org/uniprot/P31675 charge swissprot:SETA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SETA_ECOLI eggNOG ENOG4105S8Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105S8Q eggNOG ENOG410XTE9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XTE9 epestfind swissprot:SETA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SETA_ECOLI garnier swissprot:SETA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SETA_ECOLI helixturnhelix swissprot:SETA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SETA_ECOLI hmoment swissprot:SETA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SETA_ECOLI iep swissprot:SETA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SETA_ECOLI inforesidue swissprot:SETA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SETA_ECOLI octanol swissprot:SETA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SETA_ECOLI pepcoil swissprot:SETA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SETA_ECOLI pepdigest swissprot:SETA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SETA_ECOLI pepinfo swissprot:SETA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SETA_ECOLI pepnet swissprot:SETA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SETA_ECOLI pepstats swissprot:SETA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SETA_ECOLI pepwheel swissprot:SETA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SETA_ECOLI pepwindow swissprot:SETA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SETA_ECOLI sigcleave swissprot:SETA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SETA_ECOLI ## Database ID URL or Descriptions # AltName Acetokinase {ECO:0000255|HAMAP-Rule MF_00020} # BioGrid 4261690 452 # CATALYTIC ACTIVITY ATP + acetate = ADP + acetyl phosphate. {ECO:0000255|HAMAP-Rule MF_00020}. # COFACTOR ACKA_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_00020}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000255|HAMAP-Rule MF_00020}; Note=Mg(2+). Can also accept Mn(2+). {ECO 0000255|HAMAP- Rule MF_00020}; # EcoGene EG10027 ackA # FUNCTION ACKA_ECOLI Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction. During anaerobic growth of the organism, this enzyme is also involved in the synthesis of most of the ATP formed catabolically. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0008270 zinc ion binding; IDA:EcoliWiki. # GO_function GO:0008776 acetate kinase activity; IDA:EcoliWiki. # GO_process GO:0006083 acetate metabolic process; IMP:CACAO. # GO_process GO:0006085 acetyl-CoA biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0019413 acetate biosynthetic process; IGI:EcoliWiki. # GO_process GO:0019542 propionate biosynthetic process; IGI:EcoliWiki. # GO_process GO:0044011 single-species biofilm formation on inanimate substrate; IMP:CACAO. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # HAMAP MF_00020 Acetate_kinase # IntAct P0A6A3 12 # InterPro IPR000890 Aliphatic_acid_kin_short-chain # InterPro IPR004372 Ac/propionate_kinase # InterPro IPR023865 Aliphatic_acid_kinase_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00430 Taurine and hypotaurine metabolism # KEGG_Pathway ko00620 Pyruvate metabolism # KEGG_Pathway ko00640 Propanoate metabolism # KEGG_Pathway ko00680 Methane metabolism # KEGG_Pathway ko00720 Carbon fixation pathways in prokaryotes # Organism ACKA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21060 PTHR21060 # PATHWAY Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. {ECO 0000255|HAMAP-Rule:MF_00020}. # PATRIC 32119963 VBIEscCol129921_2391 # PDB 1LRG Model; -; A=1-400 # PIR JT0498 KIECAA # PIRSF PIRSF000722 Acetate_prop_kin # PRINTS PR00471 ACETATEKNASE # PROSITE PS01075 ACETATE_KINASE_1 # PROSITE PS01076 ACETATE_KINASE_2 # Pfam PF00871 Acetate_kinase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Acetate kinase {ECO:0000255|HAMAP-Rule MF_00020} # RefSeq NP_416799 NC_000913.3 # RefSeq WP_000095707 NZ_LN832404.1 # SIMILARITY Belongs to the acetokinase family. {ECO:0000255|HAMAP- Rule MF_00020}. # SUBCELLULAR LOCATION ACKA_ECOLI Cytoplasm. # SUBUNIT ACKA_ECOLI Homodimer. # TIGRFAMs TIGR00016 ackA # UniPathway UPA00340 UER00458 # eggNOG COG0282 LUCA # eggNOG ENOG4105C6H Bacteria BLAST swissprot:ACKA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ACKA_ECOLI BioCyc ECOL316407:JW2293-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2293-MONOMER BioCyc EcoCyc:ACETATEKINA-MONOMER http://biocyc.org/getid?id=EcoCyc:ACETATEKINA-MONOMER BioCyc MetaCyc:ACETATEKINA-MONOMER http://biocyc.org/getid?id=MetaCyc:ACETATEKINA-MONOMER COG COG0282 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0282 DIP DIP-9042N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9042N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.2.1 {ECO:0000255|HAMAP-Rule:MF_00020} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.2.1 {ECO:0000255|HAMAP-Rule:MF_00020} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D17576 http://www.ebi.ac.uk/ena/data/view/D17576 EMBL M22956 http://www.ebi.ac.uk/ena/data/view/M22956 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.2.1 {ECO:0000255|HAMAP-Rule:MF_00020} http://enzyme.expasy.org/EC/2.7.2.1 {ECO:0000255|HAMAP-Rule:MF_00020} EchoBASE EB0026 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0026 EcoGene EG10027 http://www.ecogene.org/geneInfo.php?eg_id=EG10027 EnsemblBacteria AAC75356 http://www.ensemblgenomes.org/id/AAC75356 EnsemblBacteria AAC75356 http://www.ensemblgenomes.org/id/AAC75356 EnsemblBacteria BAA16135 http://www.ensemblgenomes.org/id/BAA16135 EnsemblBacteria BAA16135 http://www.ensemblgenomes.org/id/BAA16135 EnsemblBacteria BAA16135 http://www.ensemblgenomes.org/id/BAA16135 EnsemblBacteria b2296 http://www.ensemblgenomes.org/id/b2296 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0008776 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008776 GO_process GO:0006083 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006083 GO_process GO:0006085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006085 GO_process GO:0019413 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019413 GO_process GO:0019542 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019542 GO_process GO:0044011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044011 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GeneID 946775 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946775 HAMAP MF_00020 http://hamap.expasy.org/unirule/MF_00020 HOGENOM HOG000288398 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000288398&db=HOGENOM6 InParanoid P0A6A3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6A3 IntAct P0A6A3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6A3* IntEnz 2.7.2.1 {ECO:0000255|HAMAP-Rule:MF_00020} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.2.1 {ECO:0000255|HAMAP-Rule:MF_00020} InterPro IPR000890 http://www.ebi.ac.uk/interpro/entry/IPR000890 InterPro IPR004372 http://www.ebi.ac.uk/interpro/entry/IPR004372 InterPro IPR023865 http://www.ebi.ac.uk/interpro/entry/IPR023865 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2293 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2293 KEGG_Gene eco:b2296 http://www.genome.jp/dbget-bin/www_bget?eco:b2296 KEGG_Orthology KO:K00925 http://www.genome.jp/dbget-bin/www_bget?KO:K00925 KEGG_Pathway ko00430 http://www.genome.jp/kegg-bin/show_pathway?ko00430 KEGG_Pathway ko00620 http://www.genome.jp/kegg-bin/show_pathway?ko00620 KEGG_Pathway ko00640 http://www.genome.jp/kegg-bin/show_pathway?ko00640 KEGG_Pathway ko00680 http://www.genome.jp/kegg-bin/show_pathway?ko00680 KEGG_Pathway ko00720 http://www.genome.jp/kegg-bin/show_pathway?ko00720 KEGG_Reaction rn:R00315 http://www.genome.jp/dbget-bin/www_bget?rn:R00315 KEGG_Reaction rn:R01353 http://www.genome.jp/dbget-bin/www_bget?rn:R01353 OMA HRLKKYI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HRLKKYI PANTHER PTHR21060 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21060 PDB 1LRG http://www.ebi.ac.uk/pdbe-srv/view/entry/1LRG PDBsum 1LRG http://www.ebi.ac.uk/pdbsum/1LRG PRINTS PR00471 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00471 PROSITE PS01075 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01075 PROSITE PS01076 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01076 PSORT swissprot:ACKA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ACKA_ECOLI PSORT-B swissprot:ACKA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ACKA_ECOLI PSORT2 swissprot:ACKA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ACKA_ECOLI Pfam PF00871 http://pfam.xfam.org/family/PF00871 Phobius swissprot:ACKA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ACKA_ECOLI PhylomeDB P0A6A3 http://phylomedb.org/?seqid=P0A6A3 ProteinModelPortal P0A6A3 http://www.proteinmodelportal.org/query/uniprot/P0A6A3 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2536666 http://www.ncbi.nlm.nih.gov/pubmed/2536666 PubMed 7883769 http://www.ncbi.nlm.nih.gov/pubmed/7883769 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_416799 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416799 RefSeq WP_000095707 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000095707 SMR P0A6A3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6A3 STRING 511145.b2296 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2296&targetmode=cogs STRING COG0282 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0282&targetmode=cogs SWISS-2DPAGE P0A6A3 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A6A3 TIGRFAMs TIGR00016 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00016 UniProtKB ACKA_ECOLI http://www.uniprot.org/uniprot/ACKA_ECOLI UniProtKB-AC P0A6A3 http://www.uniprot.org/uniprot/P0A6A3 charge swissprot:ACKA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ACKA_ECOLI eggNOG COG0282 http://eggnogapi.embl.de/nog_data/html/tree/COG0282 eggNOG ENOG4105C6H http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C6H epestfind swissprot:ACKA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ACKA_ECOLI garnier swissprot:ACKA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ACKA_ECOLI helixturnhelix swissprot:ACKA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ACKA_ECOLI hmoment swissprot:ACKA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ACKA_ECOLI iep swissprot:ACKA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ACKA_ECOLI inforesidue swissprot:ACKA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ACKA_ECOLI octanol swissprot:ACKA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ACKA_ECOLI pepcoil swissprot:ACKA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ACKA_ECOLI pepdigest swissprot:ACKA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ACKA_ECOLI pepinfo swissprot:ACKA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ACKA_ECOLI pepnet swissprot:ACKA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ACKA_ECOLI pepstats swissprot:ACKA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ACKA_ECOLI pepwheel swissprot:ACKA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ACKA_ECOLI pepwindow swissprot:ACKA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ACKA_ECOLI sigcleave swissprot:ACKA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ACKA_ECOLI ## Database ID URL or Descriptions # AltName PPID_ECOLI Rotamase D # BioGrid 4260732 116 # CATALYTIC ACTIVITY PPID_ECOLI Peptidylproline (omega=180) = peptidylproline (omega=0). # EcoGene EG13249 ppiD # FUNCTION PPID_ECOLI PPIases accelerate the folding of proteins. Seems to be involved in the folding of outer membrane proteins. Its preference at the P1 position of the peptide substrate is Glu > Leu > Ala > His > Val > Phe > Ile > Gly > Lys > Thr. # GO_component GO:0071575 integral component of external side of plasma membrane; IDA:EcoCyc. # GO_function GO:0003755 peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW. # GO_process GO:0015031 protein transport; IEA:InterPro. # GO_process GO:0061077 chaperone-mediated protein folding; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0006457 protein folding # GOslim_process GO:0006810 transport # Gene3D 1.10.3120.10 -; 1. # INDUCTION PPID_ECOLI By heat shock. # INTERACTION PPID_ECOLI Self; NbExp=2; IntAct=EBI-562001, EBI-562001; # IntAct P0ADY1 8 # InterPro IPR000297 PPIase_PpiC # InterPro IPR008880 Trigger_fac_C # InterPro IPR023058 PPIase_PpiC_CS # InterPro IPR027304 Trigger_fact/SurA_dom # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03110 Chaperones and folding catalysts # Organism PPID_ECOLI Escherichia coli (strain K12) # PATRIC 32116035 VBIEscCol129921_0459 # PDB 2KGJ NMR; -; A=264-357 # PIR A64774 A64774 # PROSITE PS01096 PPIC_PPIASE_1 # PROSITE PS50198 PPIC_PPIASE_2 # Pfam PF13145 Rotamase_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PPID_ECOLI Peptidyl-prolyl cis-trans isomerase D # RefSeq NP_414975 NC_000913.3 # RefSeq WP_000969372 NZ_LN832404.1 # SIMILARITY Contains 1 PpiC domain. {ECO:0000255|PROSITE- ProRule PRU00278}. # SUBCELLULAR LOCATION PPID_ECOLI Cell inner membrane {ECO 0000269|PubMed 16079137}; Single-pass type II membrane protein {ECO 0000269|PubMed 16079137}; Periplasmic side {ECO 0000269|PubMed 16079137}. # SUBUNIT Has been isolated as a homodimer and homotrimer from inner membrane preparations. {ECO:0000269|PubMed 16079137}. # SUPFAM SSF109998 SSF109998; 2 # eggNOG COG0760 LUCA # eggNOG ENOG4105EIN Bacteria BLAST swissprot:PPID_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PPID_ECOLI BioCyc ECOL316407:JW0431-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0431-MONOMER BioCyc EcoCyc:G6242-MONOMER http://biocyc.org/getid?id=EcoCyc:G6242-MONOMER COG COG0760 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0760 DIP DIP-39902N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-39902N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1093/emboj/17.14.3968 http://dx.doi.org/10.1093/emboj/17.14.3968 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.2.1.8 http://www.genome.jp/dbget-bin/www_bget?EC:5.2.1.8 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D82943 http://www.ebi.ac.uk/ena/data/view/D82943 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 ENZYME 5.2.1.8 http://enzyme.expasy.org/EC/5.2.1.8 EchoBASE EB3038 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3038 EcoGene EG13249 http://www.ecogene.org/geneInfo.php?eg_id=EG13249 EnsemblBacteria AAC73544 http://www.ensemblgenomes.org/id/AAC73544 EnsemblBacteria AAC73544 http://www.ensemblgenomes.org/id/AAC73544 EnsemblBacteria BAE76221 http://www.ensemblgenomes.org/id/BAE76221 EnsemblBacteria BAE76221 http://www.ensemblgenomes.org/id/BAE76221 EnsemblBacteria BAE76221 http://www.ensemblgenomes.org/id/BAE76221 EnsemblBacteria b0441 http://www.ensemblgenomes.org/id/b0441 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0071575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071575 GO_function GO:0003755 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003755 GO_process GO:0015031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031 GO_process GO:0061077 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061077 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 1.10.3120.10 http://www.cathdb.info/version/latest/superfamily/1.10.3120.10 GeneID 946056 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946056 HOGENOM HOG000276975 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276975&db=HOGENOM6 InParanoid P0ADY1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADY1 IntAct P0ADY1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADY1* IntEnz 5.2.1.8 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.2.1.8 InterPro IPR000297 http://www.ebi.ac.uk/interpro/entry/IPR000297 InterPro IPR008880 http://www.ebi.ac.uk/interpro/entry/IPR008880 InterPro IPR023058 http://www.ebi.ac.uk/interpro/entry/IPR023058 InterPro IPR027304 http://www.ebi.ac.uk/interpro/entry/IPR027304 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW0431 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0431 KEGG_Gene eco:b0441 http://www.genome.jp/dbget-bin/www_bget?eco:b0441 KEGG_Orthology KO:K03770 http://www.genome.jp/dbget-bin/www_bget?KO:K03770 OMA DQVIRQM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DQVIRQM PDB 2KGJ http://www.ebi.ac.uk/pdbe-srv/view/entry/2KGJ PDBsum 2KGJ http://www.ebi.ac.uk/pdbsum/2KGJ PROSITE PS01096 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01096 PROSITE PS50198 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50198 PSORT swissprot:PPID_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PPID_ECOLI PSORT-B swissprot:PPID_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PPID_ECOLI PSORT2 swissprot:PPID_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PPID_ECOLI Pfam PF13145 http://pfam.xfam.org/family/PF13145 Phobius swissprot:PPID_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PPID_ECOLI PhylomeDB P0ADY1 http://phylomedb.org/?seqid=P0ADY1 ProteinModelPortal P0ADY1 http://www.proteinmodelportal.org/query/uniprot/P0ADY1 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9670013 http://www.ncbi.nlm.nih.gov/pubmed/9670013 RefSeq NP_414975 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414975 RefSeq WP_000969372 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000969372 SMR P0ADY1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADY1 STRING 511145.b0441 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0441&targetmode=cogs STRING COG0760 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0760&targetmode=cogs SUPFAM SSF109998 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF109998 UniProtKB PPID_ECOLI http://www.uniprot.org/uniprot/PPID_ECOLI UniProtKB-AC P0ADY1 http://www.uniprot.org/uniprot/P0ADY1 charge swissprot:PPID_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PPID_ECOLI eggNOG COG0760 http://eggnogapi.embl.de/nog_data/html/tree/COG0760 eggNOG ENOG4105EIN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EIN epestfind swissprot:PPID_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PPID_ECOLI garnier swissprot:PPID_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PPID_ECOLI helixturnhelix swissprot:PPID_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PPID_ECOLI hmoment swissprot:PPID_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PPID_ECOLI iep swissprot:PPID_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PPID_ECOLI inforesidue swissprot:PPID_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PPID_ECOLI octanol swissprot:PPID_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PPID_ECOLI pepcoil swissprot:PPID_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PPID_ECOLI pepdigest swissprot:PPID_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PPID_ECOLI pepinfo swissprot:PPID_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PPID_ECOLI pepnet swissprot:PPID_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PPID_ECOLI pepstats swissprot:PPID_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PPID_ECOLI pepwheel swissprot:PPID_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PPID_ECOLI pepwindow swissprot:PPID_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PPID_ECOLI sigcleave swissprot:PPID_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PPID_ECOLI ## Database ID URL or Descriptions # BioGrid 4263021 20 # EcoGene EG13748 ynbA # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0016780 phosphotransferase activity, for other substituted phosphate groups; IEA:InterPro. # GO_process GO:0008654 phospholipid biosynthetic process; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # InterPro IPR000462 CDP-OH_P_trans # Organism YNBA_ECOLI Escherichia coli (strain K12) # PATRIC 32118102 VBIEscCol129921_1471 # PIR C64892 C64892 # Pfam PF01066 CDP-OH_P_transf # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNBA_ECOLI Inner membrane protein YnbA # RefSeq NP_415926 NC_000913.3 # RefSeq WP_000177515 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA25405.1; Type=Frameshift; Positions=5; Evidence={ECO 0000305}; # SUBCELLULAR LOCATION YNBA_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG COG0558 LUCA # eggNOG ENOG4108UMZ Bacteria BLAST swissprot:YNBA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNBA_ECOLI BioCyc ECOL316407:JW1405-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1405-MONOMER BioCyc EcoCyc:G6727-MONOMER http://biocyc.org/getid?id=EcoCyc:G6727-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D85081 http://www.ebi.ac.uk/ena/data/view/D85081 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3511 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3511 EcoGene EG13748 http://www.ecogene.org/geneInfo.php?eg_id=EG13748 EnsemblBacteria AAC74490 http://www.ensemblgenomes.org/id/AAC74490 EnsemblBacteria AAC74490 http://www.ensemblgenomes.org/id/AAC74490 EnsemblBacteria BAE76430 http://www.ensemblgenomes.org/id/BAE76430 EnsemblBacteria BAE76430 http://www.ensemblgenomes.org/id/BAE76430 EnsemblBacteria BAE76430 http://www.ensemblgenomes.org/id/BAE76430 EnsemblBacteria b1408 http://www.ensemblgenomes.org/id/b1408 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0016780 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016780 GO_process GO:0008654 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008654 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 945973 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945973 HOGENOM HOG000259022 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000259022&db=HOGENOM6 InParanoid P76090 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76090 InterPro IPR000462 http://www.ebi.ac.uk/interpro/entry/IPR000462 KEGG_Gene ecj:JW1405 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1405 KEGG_Gene eco:b1408 http://www.genome.jp/dbget-bin/www_bget?eco:b1408 OMA QLKPRFQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QLKPRFQ PSORT swissprot:YNBA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNBA_ECOLI PSORT-B swissprot:YNBA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNBA_ECOLI PSORT2 swissprot:YNBA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNBA_ECOLI Pfam PF01066 http://pfam.xfam.org/family/PF01066 Phobius swissprot:YNBA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNBA_ECOLI PhylomeDB P76090 http://phylomedb.org/?seqid=P76090 ProteinModelPortal P76090 http://www.proteinmodelportal.org/query/uniprot/P76090 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415926 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415926 RefSeq WP_000177515 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000177515 STRING 511145.b1408 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1408&targetmode=cogs UniProtKB YNBA_ECOLI http://www.uniprot.org/uniprot/YNBA_ECOLI UniProtKB-AC P76090 http://www.uniprot.org/uniprot/P76090 charge swissprot:YNBA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNBA_ECOLI eggNOG COG0558 http://eggnogapi.embl.de/nog_data/html/tree/COG0558 eggNOG ENOG4108UMZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UMZ epestfind swissprot:YNBA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNBA_ECOLI garnier swissprot:YNBA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNBA_ECOLI helixturnhelix swissprot:YNBA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNBA_ECOLI hmoment swissprot:YNBA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNBA_ECOLI iep swissprot:YNBA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNBA_ECOLI inforesidue swissprot:YNBA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNBA_ECOLI octanol swissprot:YNBA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNBA_ECOLI pepcoil swissprot:YNBA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNBA_ECOLI pepdigest swissprot:YNBA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNBA_ECOLI pepinfo swissprot:YNBA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNBA_ECOLI pepnet swissprot:YNBA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNBA_ECOLI pepstats swissprot:YNBA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNBA_ECOLI pepwheel swissprot:YNBA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNBA_ECOLI pepwindow swissprot:YNBA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNBA_ECOLI sigcleave swissprot:YNBA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNBA_ECOLI ## Database ID URL or Descriptions # AltName TOLC_ECOLI Multidrug efflux pump subunit TolC # AltName TOLC_ECOLI Outer membrane factor TolC # BioGrid 4263248 380 # DISRUPTION PHENOTYPE Cannot grow on efflux substrates novobiocin or fusidic acid. {ECO:0000269|PubMed 15228545}. # DOMAIN TOLC_ECOLI Forms a continuous, solvent-accessible conduit a 'channel-tunnel' over 140 Angstroms long that spans both the outer membrane and periplasmic space. The periplasmic or proximal end of the tunnel is sealed by sets of coiled helices. {ECO 0000269|PubMed 10879525}. # ENZYME REGULATION In vitro, inhibited by hexaamminecobalt(3+). {ECO:0000269|PubMed 15342230}. # EcoGene EG11009 tolC # FUNCTION TOLC_ECOLI Outer membrane channel, which is required for the function of several efflux systems such as AcrAB-TolC, AcrEF-TolC, EmrAB-TolC and MacAB-TolC. These systems are involved in export of antibiotics and other toxic compounds from the cell. TolC is also involved in import of colicin E1 into the cells. {ECO 0000269|PubMed 11274125, ECO 0000269|PubMed 15228545, ECO 0000269|PubMed 18955484, ECO 0000269|PubMed 23176499, ECO 0000269|PubMed 6337123}. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015288 porin activity; IDA:EcoCyc. # GO_function GO:0015562 efflux transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0014070 response to organic cyclic compound; IMP:EcoliWiki. # GO_process GO:0042930 enterobactin transport; IGI:EcoliWiki. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # INTERACTION TOLC_ECOLI Self; NbExp=2; IntAct=EBI-875614, EBI-875614; # IntAct P02930 5 # InterPro IPR003423 OMP_efflux # InterPro IPR010130 T1SS_OMP_TolC # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00325 alpha-Hemolysin/cyclolysin transport system # KEGG_Brite ko02000 Transporters # KEGG_Brite ko02044 M00326 RTX toxin transport system # KEGG_Brite ko02044 M00339 RaxAB-RaxC type I secretion system # KEGG_Brite ko02044 M00571 AlgE-type Mannuronan C-5-Epimerase transport system # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko03070 Bacterial secretion system # KEGG_Pathway ko04626 Plant-pathogen interaction # KEGG_Pathway ko05133 Pertussis # Organism TOLC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30026:SF3 PTHR30026:SF3 # PATRIC 32121480 VBIEscCol129921_3127 # PDB 1EK9 X-ray; 2.10 A; A/B/C=23-450 # PDB 1TQQ X-ray; 2.75 A; A/B/C=23-493 # PDB 2VDD X-ray; 3.30 A; A/B/C=1-450 # PDB 2VDE X-ray; 3.20 A; A/B/C=1-450 # PDB 2WMZ X-ray; 2.90 A; A/B/C=23-450 # PDB 2XMN X-ray; 2.85 A; A/B/C=23-450 # PIR A65091 MMECTC # Pfam PF02321 OEP; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TOLC_ECOLI Outer membrane protein TolC # RefSeq NP_417507 NC_000913.3 # RefSeq WP_000735278 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA69203.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA24751.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=CAA37982.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; # SIMILARITY Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. {ECO 0000305}. # SUBCELLULAR LOCATION TOLC_ECOLI Cell outer membrane {ECO 0000269|PubMed 15228545, ECO 0000269|PubMed 16079137, ECO 0000269|PubMed 21778229, ECO 0000269|PubMed 6337123, ECO 0000269|PubMed 9044294}; Multi-pass membrane protein {ECO 0000269|PubMed 15228545, ECO 0000269|PubMed 16079137, ECO 0000269|PubMed 21778229, ECO 0000269|PubMed 6337123, ECO 0000269|PubMed 9044294}. # SUBUNIT TOLC_ECOLI Homotrimer. Part of tripartite efflux systems, which are composed of an inner membrane transporter, a periplasmic membrane fusion protein, and an outer membrane component, TolC. The complexes form a large protein conduit and can translocate molecules across both the inner and outer membranes. TolC interacts with the membrane fusion proteins AcrA, EmrA and MacA. {ECO 0000269|PubMed 15228545, ECO 0000269|PubMed 15342230, ECO 0000269|PubMed 16079137, ECO 0000269|PubMed 18955484, ECO 0000269|PubMed 19342493, ECO 0000269|PubMed 19805313, ECO 0000269|PubMed 21325274, ECO 0000269|PubMed 9044294}. # TCDB 1.B.17.1 the outer membrane factor (omf) family # TIGRFAMs TIGR01844 type_I_sec_TolC # eggNOG COG1538 LUCA # eggNOG ENOG4105DFG Bacteria BLAST swissprot:TOLC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TOLC_ECOLI BioCyc ECOL316407:JW5503-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5503-MONOMER BioCyc EcoCyc:EG11009-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11009-MONOMER BioCyc MetaCyc:EG11009-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11009-MONOMER COG COG1538 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1538 DIP DIP-11007N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11007N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1002/elps.1150190539 http://dx.doi.org/10.1002/elps.1150190539 DOI 10.1016/0014-5793(83)80518-3 http://dx.doi.org/10.1016/0014-5793(83)80518-3 DOI 10.1016/j.jmb.2004.07.088 http://dx.doi.org/10.1016/j.jmb.2004.07.088 DOI 10.1016/j.molcel.2008.02.015 http://dx.doi.org/10.1016/j.molcel.2008.02.015 DOI 10.1038/35016007 http://dx.doi.org/10.1038/35016007 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/BST20120211 http://dx.doi.org/10.1042/BST20120211 DOI 10.1046/j.1365-2958.1997.d01-1880.x http://dx.doi.org/10.1046/j.1365-2958.1997.d01-1880.x DOI 10.1073/pnas.0900693106 http://dx.doi.org/10.1073/pnas.0900693106 DOI 10.1073/pnas.0906601106 http://dx.doi.org/10.1073/pnas.0906601106 DOI 10.1073/pnas.1012588108 http://dx.doi.org/10.1073/pnas.1012588108 DOI 10.1074/jbc.M110.202598 http://dx.doi.org/10.1074/jbc.M110.202598 DOI 10.1074/jbc.M111.245696 http://dx.doi.org/10.1074/jbc.M111.245696 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1074/jbc.M806964200 http://dx.doi.org/10.1074/jbc.M806964200 DOI 10.1093/nar/11.18.6487 http://dx.doi.org/10.1093/nar/11.18.6487 DOI 10.1093/nar/18.18.5547 http://dx.doi.org/10.1093/nar/18.18.5547 DOI 10.1111/j.1365-2958.2004.04158.x http://dx.doi.org/10.1111/j.1365-2958.2004.04158.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.183.8.2646-2653.2001 http://dx.doi.org/10.1128/JB.183.8.2646-2653.2001 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EMBL V01505 http://www.ebi.ac.uk/ena/data/view/V01505 EMBL X00016 http://www.ebi.ac.uk/ena/data/view/X00016 EMBL X54049 http://www.ebi.ac.uk/ena/data/view/X54049 EchoBASE EB1002 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1002 EcoGene EG11009 http://www.ecogene.org/geneInfo.php?eg_id=EG11009 EnsemblBacteria AAC76071 http://www.ensemblgenomes.org/id/AAC76071 EnsemblBacteria AAC76071 http://www.ensemblgenomes.org/id/AAC76071 EnsemblBacteria BAE77091 http://www.ensemblgenomes.org/id/BAE77091 EnsemblBacteria BAE77091 http://www.ensemblgenomes.org/id/BAE77091 EnsemblBacteria BAE77091 http://www.ensemblgenomes.org/id/BAE77091 EnsemblBacteria b3035 http://www.ensemblgenomes.org/id/b3035 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015288 GO_function GO:0015562 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015562 GO_process GO:0014070 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0014070 GO_process GO:0042930 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042930 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 947521 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947521 HOGENOM HOG000283506 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000283506&db=HOGENOM6 InParanoid P02930 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P02930 IntAct P02930 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P02930* InterPro IPR003423 http://www.ebi.ac.uk/interpro/entry/IPR003423 InterPro IPR010130 http://www.ebi.ac.uk/interpro/entry/IPR010130 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW5503 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5503 KEGG_Gene eco:b3035 http://www.genome.jp/dbget-bin/www_bget?eco:b3035 KEGG_Orthology KO:K12340 http://www.genome.jp/dbget-bin/www_bget?KO:K12340 KEGG_Pathway ko03070 http://www.genome.jp/kegg-bin/show_pathway?ko03070 KEGG_Pathway ko04626 http://www.genome.jp/kegg-bin/show_pathway?ko04626 KEGG_Pathway ko05133 http://www.genome.jp/kegg-bin/show_pathway?ko05133 OMA AMSQAEN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AMSQAEN PANTHER PTHR30026:SF3 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30026:SF3 PDB 1EK9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1EK9 PDB 1TQQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1TQQ PDB 2VDD http://www.ebi.ac.uk/pdbe-srv/view/entry/2VDD PDB 2VDE http://www.ebi.ac.uk/pdbe-srv/view/entry/2VDE PDB 2WMZ http://www.ebi.ac.uk/pdbe-srv/view/entry/2WMZ PDB 2XMN http://www.ebi.ac.uk/pdbe-srv/view/entry/2XMN PDBsum 1EK9 http://www.ebi.ac.uk/pdbsum/1EK9 PDBsum 1TQQ http://www.ebi.ac.uk/pdbsum/1TQQ PDBsum 2VDD http://www.ebi.ac.uk/pdbsum/2VDD PDBsum 2VDE http://www.ebi.ac.uk/pdbsum/2VDE PDBsum 2WMZ http://www.ebi.ac.uk/pdbsum/2WMZ PDBsum 2XMN http://www.ebi.ac.uk/pdbsum/2XMN PSORT swissprot:TOLC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TOLC_ECOLI PSORT-B swissprot:TOLC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TOLC_ECOLI PSORT2 swissprot:TOLC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TOLC_ECOLI Pfam PF02321 http://pfam.xfam.org/family/PF02321 Phobius swissprot:TOLC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TOLC_ECOLI PhylomeDB P02930 http://phylomedb.org/?seqid=P02930 ProteinModelPortal P02930 http://www.proteinmodelportal.org/query/uniprot/P02930 PubMed 10879525 http://www.ncbi.nlm.nih.gov/pubmed/10879525 PubMed 11274125 http://www.ncbi.nlm.nih.gov/pubmed/11274125 PubMed 15228545 http://www.ncbi.nlm.nih.gov/pubmed/15228545 PubMed 15342230 http://www.ncbi.nlm.nih.gov/pubmed/15342230 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18406332 http://www.ncbi.nlm.nih.gov/pubmed/18406332 PubMed 18955484 http://www.ncbi.nlm.nih.gov/pubmed/18955484 PubMed 19342493 http://www.ncbi.nlm.nih.gov/pubmed/19342493 PubMed 19805313 http://www.ncbi.nlm.nih.gov/pubmed/19805313 PubMed 21245342 http://www.ncbi.nlm.nih.gov/pubmed/21245342 PubMed 21325274 http://www.ncbi.nlm.nih.gov/pubmed/21325274 PubMed 21778229 http://www.ncbi.nlm.nih.gov/pubmed/21778229 PubMed 2216730 http://www.ncbi.nlm.nih.gov/pubmed/2216730 PubMed 23176499 http://www.ncbi.nlm.nih.gov/pubmed/23176499 PubMed 6303857 http://www.ncbi.nlm.nih.gov/pubmed/6303857 PubMed 6312426 http://www.ncbi.nlm.nih.gov/pubmed/6312426 PubMed 6337123 http://www.ncbi.nlm.nih.gov/pubmed/6337123 PubMed 9044294 http://www.ncbi.nlm.nih.gov/pubmed/9044294 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9629924 http://www.ncbi.nlm.nih.gov/pubmed/9629924 RefSeq NP_417507 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417507 RefSeq WP_000735278 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000735278 SMR P02930 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P02930 STRING 511145.b3035 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3035&targetmode=cogs STRING COG1538 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1538&targetmode=cogs SWISS-2DPAGE P02930 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P02930 TCDB 1.B.17.1 http://www.tcdb.org/search/result.php?tc=1.B.17.1 TIGRFAMs TIGR01844 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01844 UniProtKB TOLC_ECOLI http://www.uniprot.org/uniprot/TOLC_ECOLI UniProtKB-AC P02930 http://www.uniprot.org/uniprot/P02930 charge swissprot:TOLC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TOLC_ECOLI eggNOG COG1538 http://eggnogapi.embl.de/nog_data/html/tree/COG1538 eggNOG ENOG4105DFG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DFG epestfind swissprot:TOLC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TOLC_ECOLI garnier swissprot:TOLC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TOLC_ECOLI helixturnhelix swissprot:TOLC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TOLC_ECOLI hmoment swissprot:TOLC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TOLC_ECOLI iep swissprot:TOLC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TOLC_ECOLI inforesidue swissprot:TOLC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TOLC_ECOLI octanol swissprot:TOLC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TOLC_ECOLI pepcoil swissprot:TOLC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TOLC_ECOLI pepdigest swissprot:TOLC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TOLC_ECOLI pepinfo swissprot:TOLC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TOLC_ECOLI pepnet swissprot:TOLC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TOLC_ECOLI pepstats swissprot:TOLC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TOLC_ECOLI pepwheel swissprot:TOLC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TOLC_ECOLI pepwindow swissprot:TOLC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TOLC_ECOLI sigcleave swissprot:TOLC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TOLC_ECOLI ## Database ID URL or Descriptions # BioGrid 4262161 576 # EcoGene EG12248 yhjD # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_function GO:0005215 transporter activity; IMP:EcoCyc. # GO_function GO:0015221 lipopolysaccharide transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0006810 transport; IMP:EcoCyc. # GO_process GO:0015920 lipopolysaccharide transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR005274 IM_pro_YhjD # InterPro IPR017039 Virul_fac_BrkB # Organism YHJD_ECOLI Escherichia coli (strain K12) # PATRIC 32122506 VBIEscCol129921_3631 # PIR S47742 S47742 # PIRSF PIRSF035875 RNase_BN # Pfam PF03631 Virul_fac_BrkB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHJD_ECOLI Inner membrane protein YhjD # RefSeq NP_417979 NC_000913.3 # RefSeq WP_000191237 NZ_LN832404.1 # SUBCELLULAR LOCATION YHJD_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 9.B.126.1 the putative lipid iv exporter (yhjd) family # TIGRFAMs TIGR00766 TIGR00766 # eggNOG COG1295 LUCA # eggNOG ENOG4107H3J Bacteria BLAST swissprot:YHJD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHJD_ECOLI BioCyc ECOL316407:JW3490-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3490-MONOMER BioCyc EcoCyc:EG12248-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12248-MONOMER COG COG1295 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1295 DIP DIP-12379N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12379N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2159 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2159 EcoGene EG12248 http://www.ecogene.org/geneInfo.php?eg_id=EG12248 EnsemblBacteria AAC76547 http://www.ensemblgenomes.org/id/AAC76547 EnsemblBacteria AAC76547 http://www.ensemblgenomes.org/id/AAC76547 EnsemblBacteria BAE77772 http://www.ensemblgenomes.org/id/BAE77772 EnsemblBacteria BAE77772 http://www.ensemblgenomes.org/id/BAE77772 EnsemblBacteria BAE77772 http://www.ensemblgenomes.org/id/BAE77772 EnsemblBacteria b3522 http://www.ensemblgenomes.org/id/b3522 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_function GO:0015221 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015221 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GO_process GO:0015920 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015920 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948033 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948033 HOGENOM HOG000045666 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000045666&db=HOGENOM6 InParanoid P37642 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37642 IntAct P37642 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37642* InterPro IPR005274 http://www.ebi.ac.uk/interpro/entry/IPR005274 InterPro IPR017039 http://www.ebi.ac.uk/interpro/entry/IPR017039 KEGG_Gene ecj:JW3490 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3490 KEGG_Gene eco:b3522 http://www.genome.jp/dbget-bin/www_bget?eco:b3522 KEGG_Orthology KO:K07058 http://www.genome.jp/dbget-bin/www_bget?KO:K07058 MINT MINT-1272164 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1272164 OMA MGNQFGA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MGNQFGA PSORT swissprot:YHJD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHJD_ECOLI PSORT-B swissprot:YHJD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHJD_ECOLI PSORT2 swissprot:YHJD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHJD_ECOLI Pfam PF03631 http://pfam.xfam.org/family/PF03631 Phobius swissprot:YHJD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHJD_ECOLI PhylomeDB P37642 http://phylomedb.org/?seqid=P37642 ProteinModelPortal P37642 http://www.proteinmodelportal.org/query/uniprot/P37642 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417979 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417979 RefSeq WP_000191237 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000191237 STRING 511145.b3522 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3522&targetmode=cogs STRING COG1295 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1295&targetmode=cogs TCDB 9.B.126.1 http://www.tcdb.org/search/result.php?tc=9.B.126.1 TIGRFAMs TIGR00766 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00766 UniProtKB YHJD_ECOLI http://www.uniprot.org/uniprot/YHJD_ECOLI UniProtKB-AC P37642 http://www.uniprot.org/uniprot/P37642 charge swissprot:YHJD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHJD_ECOLI eggNOG COG1295 http://eggnogapi.embl.de/nog_data/html/tree/COG1295 eggNOG ENOG4107H3J http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107H3J epestfind swissprot:YHJD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHJD_ECOLI garnier swissprot:YHJD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHJD_ECOLI helixturnhelix swissprot:YHJD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHJD_ECOLI hmoment swissprot:YHJD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHJD_ECOLI iep swissprot:YHJD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHJD_ECOLI inforesidue swissprot:YHJD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHJD_ECOLI octanol swissprot:YHJD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHJD_ECOLI pepcoil swissprot:YHJD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHJD_ECOLI pepdigest swissprot:YHJD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHJD_ECOLI pepinfo swissprot:YHJD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHJD_ECOLI pepnet swissprot:YHJD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHJD_ECOLI pepstats swissprot:YHJD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHJD_ECOLI pepwheel swissprot:YHJD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHJD_ECOLI pepwindow swissprot:YHJD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHJD_ECOLI sigcleave swissprot:YHJD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHJD_ECOLI ## Database ID URL or Descriptions # BioGrid 4260031 9 # DISRUPTION PHENOTYPE Mutants grown in rich medium show severe defects in chromosome segregation and cell division. {ECO:0000269|PubMed 18984159}. # EcoGene EG12855 matP # FUNCTION MATP_ECOLI Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain. {ECO 0000255|HAMAP-Rule MF_01073, ECO 0000269|PubMed 18984159}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_component GO:0097047 DNA replication termination region; IDA:EcoCyc. # GO_function GO:0043565 sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0007049 cell cycle; IEA:UniProtKB-KW. # GO_process GO:0007059 chromosome segregation; IMP:EcoCyc. # GO_process GO:0051276 chromosome organization; IDA:EcoCyc. # GO_process GO:0051301 cell division; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0007049 cell cycle # GOslim_process GO:0007059 chromosome segregation # GOslim_process GO:0051276 chromosome organization # GOslim_process GO:0051301 cell division # HAMAP MF_01073 MatP # IntAct P0A8N0 24 # InterPro IPR009390 MatP # Organism MATP_ECOLI Escherichia coli (strain K12) # PATRIC 32117131 VBIEscCol129921_0990 # PDB 4D8J X-ray; 3.55 A; A/B/C/D/G/H/K/L=1-150 # PIR C64836 C64836 # Pfam PF06303 MatP # ProDom PD033720 DUF1047 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Macrodomain Ter protein {ECO:0000255|HAMAP-Rule MF_01073} # RefSeq NP_415476 NC_000913.3 # RefSeq WP_000877161 NZ_LN832404.1 # SIMILARITY Belongs to the MatP family. {ECO:0000255|HAMAP- Rule MF_01073}. # SUBCELLULAR LOCATION MATP_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_01073, ECO 0000269|PubMed 18984159}. Note=Accumulates in the cell as a discrete focus that colocalizes with the Ter macrodomain. # SUBUNIT MATP_ECOLI Homodimer. {ECO 0000255|HAMAP-Rule MF_01073, ECO 0000269|PubMed 18984159}. # eggNOG COG3120 LUCA # eggNOG ENOG4108R9Q Bacteria BLAST swissprot:MATP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MATP_ECOLI BioCyc ECOL316407:JW0939-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0939-MONOMER BioCyc EcoCyc:EG12855-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12855-MONOMER COG COG3120 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3120 DOI 10.1016/j.cell.2008.08.031 http://dx.doi.org/10.1016/j.cell.2008.08.031 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1093/nar/8.13.3011 http://dx.doi.org/10.1093/nar/8.13.3011 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00307 http://www.ebi.ac.uk/ena/data/view/V00307 EchoBASE EB2699 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2699 EcoGene EG12855 http://www.ecogene.org/geneInfo.php?eg_id=EG12855 EnsemblBacteria AAC74042 http://www.ensemblgenomes.org/id/AAC74042 EnsemblBacteria AAC74042 http://www.ensemblgenomes.org/id/AAC74042 EnsemblBacteria BAA35714 http://www.ensemblgenomes.org/id/BAA35714 EnsemblBacteria BAA35714 http://www.ensemblgenomes.org/id/BAA35714 EnsemblBacteria BAA35714 http://www.ensemblgenomes.org/id/BAA35714 EnsemblBacteria b0956 http://www.ensemblgenomes.org/id/b0956 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0097047 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097047 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GO_process GO:0007059 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007059 GO_process GO:0051276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051276 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GOslim_process GO:0007059 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007059 GOslim_process GO:0051276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051276 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GeneID 945570 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945570 HAMAP MF_01073 http://hamap.expasy.org/unirule/MF_01073 HOGENOM HOG000218369 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218369&db=HOGENOM6 IntAct P0A8N0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8N0* InterPro IPR009390 http://www.ebi.ac.uk/interpro/entry/IPR009390 KEGG_Gene ecj:JW0939 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0939 KEGG_Gene eco:b0956 http://www.genome.jp/dbget-bin/www_bget?eco:b0956 KEGG_Orthology KO:K09911 http://www.genome.jp/dbget-bin/www_bget?KO:K09911 OMA MSTLKQD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MSTLKQD PDB 4D8J http://www.ebi.ac.uk/pdbe-srv/view/entry/4D8J PDBsum 4D8J http://www.ebi.ac.uk/pdbsum/4D8J PSORT swissprot:MATP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MATP_ECOLI PSORT-B swissprot:MATP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MATP_ECOLI PSORT2 swissprot:MATP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MATP_ECOLI Pfam PF06303 http://pfam.xfam.org/family/PF06303 Phobius swissprot:MATP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MATP_ECOLI ProteinModelPortal P0A8N0 http://www.proteinmodelportal.org/query/uniprot/P0A8N0 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18984159 http://www.ncbi.nlm.nih.gov/pubmed/18984159 PubMed 6253901 http://www.ncbi.nlm.nih.gov/pubmed/6253901 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415476 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415476 RefSeq WP_000877161 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000877161 SMR P0A8N0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8N0 STRING 511145.b0956 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0956&targetmode=cogs STRING COG3120 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3120&targetmode=cogs UniProtKB MATP_ECOLI http://www.uniprot.org/uniprot/MATP_ECOLI UniProtKB-AC P0A8N0 http://www.uniprot.org/uniprot/P0A8N0 charge swissprot:MATP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MATP_ECOLI eggNOG COG3120 http://eggnogapi.embl.de/nog_data/html/tree/COG3120 eggNOG ENOG4108R9Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108R9Q epestfind swissprot:MATP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MATP_ECOLI garnier swissprot:MATP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MATP_ECOLI helixturnhelix swissprot:MATP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MATP_ECOLI hmoment swissprot:MATP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MATP_ECOLI iep swissprot:MATP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MATP_ECOLI inforesidue swissprot:MATP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MATP_ECOLI octanol swissprot:MATP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MATP_ECOLI pepcoil swissprot:MATP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MATP_ECOLI pepdigest swissprot:MATP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MATP_ECOLI pepinfo swissprot:MATP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MATP_ECOLI pepnet swissprot:MATP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MATP_ECOLI pepstats swissprot:MATP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MATP_ECOLI pepwheel swissprot:MATP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MATP_ECOLI pepwindow swissprot:MATP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MATP_ECOLI sigcleave swissprot:MATP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MATP_ECOLI ## Database ID URL or Descriptions # BioGrid 4259503 25 # EcoGene EG14141 yfdS # GO_process GO:0006979 response to oxidative stress; IMP:EcoCyc. # GOslim_process GO:0006950 response to stress # IntAct P76515 13 # Organism YFDS_ECOLI Escherichia coli (strain K12) # PATRIC 32120101 VBIEscCol129921_2459 # PIR G65009 G65009 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFDS_ECOLI Uncharacterized protein YfdS # RefSeq NP_416863 NC_000913.3 # RefSeq WP_001242717 NZ_LN832404.1 # SIMILARITY To the N-terminal region of phage HK97/HK620 Gp37/hpaH. {ECO 0000305}. # eggNOG ENOG41077V0 Bacteria # eggNOG ENOG410Z64A LUCA BLAST swissprot:YFDS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFDS_ECOLI BioCyc ECOL316407:JW2359-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2359-MONOMER BioCyc EcoCyc:G7231-MONOMER http://biocyc.org/getid?id=EcoCyc:G7231-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3893 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3893 EcoGene EG14141 http://www.ecogene.org/geneInfo.php?eg_id=EG14141 EnsemblBacteria AAC75421 http://www.ensemblgenomes.org/id/AAC75421 EnsemblBacteria AAC75421 http://www.ensemblgenomes.org/id/AAC75421 EnsemblBacteria BAE76701 http://www.ensemblgenomes.org/id/BAE76701 EnsemblBacteria BAE76701 http://www.ensemblgenomes.org/id/BAE76701 EnsemblBacteria BAE76701 http://www.ensemblgenomes.org/id/BAE76701 EnsemblBacteria b2362 http://www.ensemblgenomes.org/id/b2362 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 946426 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946426 HOGENOM HOG000127664 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000127664&db=HOGENOM6 IntAct P76515 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76515* KEGG_Gene ecj:JW2359 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2359 KEGG_Gene eco:b2362 http://www.genome.jp/dbget-bin/www_bget?eco:b2362 OMA FNITHWA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FNITHWA PSORT swissprot:YFDS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFDS_ECOLI PSORT-B swissprot:YFDS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFDS_ECOLI PSORT2 swissprot:YFDS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFDS_ECOLI Phobius swissprot:YFDS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFDS_ECOLI ProteinModelPortal P76515 http://www.proteinmodelportal.org/query/uniprot/P76515 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416863 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416863 RefSeq WP_001242717 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001242717 STRING 511145.b2362 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2362&targetmode=cogs UniProtKB YFDS_ECOLI http://www.uniprot.org/uniprot/YFDS_ECOLI UniProtKB-AC P76515 http://www.uniprot.org/uniprot/P76515 charge swissprot:YFDS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFDS_ECOLI eggNOG ENOG41077V0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41077V0 eggNOG ENOG410Z64A http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Z64A epestfind swissprot:YFDS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFDS_ECOLI garnier swissprot:YFDS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFDS_ECOLI helixturnhelix swissprot:YFDS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFDS_ECOLI hmoment swissprot:YFDS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFDS_ECOLI iep swissprot:YFDS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFDS_ECOLI inforesidue swissprot:YFDS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFDS_ECOLI octanol swissprot:YFDS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFDS_ECOLI pepcoil swissprot:YFDS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFDS_ECOLI pepdigest swissprot:YFDS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFDS_ECOLI pepinfo swissprot:YFDS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFDS_ECOLI pepnet swissprot:YFDS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFDS_ECOLI pepstats swissprot:YFDS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFDS_ECOLI pepwheel swissprot:YFDS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFDS_ECOLI pepwindow swissprot:YFDS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFDS_ECOLI sigcleave swissprot:YFDS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFDS_ECOLI ## Database ID URL or Descriptions # BioGrid 4261039 9 # EcoGene EG13278 yedK # GO_function GO:0008233 peptidase activity; IEA:UniProtKB-KW. # GOslim_function GO:0008233 peptidase activity # Gene3D 3.90.1680.10 -; 1. # IntAct P76318 14 # InterPro IPR003738 SRAP # Organism YEDK_ECOLI Escherichia coli (strain K12) # PANTHER PTHR13604 PTHR13604 # PATRIC 32119197 VBIEscCol129921_2013 # PDB 2ICU X-ray; 1.60 A; A/B=1-222 # PIR H64956 H64956 # Pfam PF02586 SRAP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEDK_ECOLI Putative SOS response-associated peptidase YedK # RefSeq WP_000334583 NZ_LN832404.1 # RefSeq YP_025310 NC_000913.3 # SIMILARITY Belongs to the SOS response-associated peptidase family. {ECO 0000305}. # SUPFAM SSF143081 SSF143081 # eggNOG COG2135 LUCA # eggNOG ENOG4108RAV Bacteria BLAST swissprot:YEDK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEDK_ECOLI BioCyc ECOL316407:JW1916-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1916-MONOMER BioCyc EcoCyc:EG11662-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11662-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1099/00221287-139-7-1401 http://dx.doi.org/10.1099/00221287-139-7-1401 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1186/1745-6150-8-20 http://dx.doi.org/10.1186/1745-6150-8-20 EC_number EC:3.4.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.4.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L13279 http://www.ebi.ac.uk/ena/data/view/L13279 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.4.-.- http://enzyme.expasy.org/EC/3.4.-.- EchoBASE EB3063 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3063 EcoGene EG13278 http://www.ecogene.org/geneInfo.php?eg_id=EG13278 EnsemblBacteria AAT48139 http://www.ensemblgenomes.org/id/AAT48139 EnsemblBacteria AAT48139 http://www.ensemblgenomes.org/id/AAT48139 EnsemblBacteria BAE76551 http://www.ensemblgenomes.org/id/BAE76551 EnsemblBacteria BAE76551 http://www.ensemblgenomes.org/id/BAE76551 EnsemblBacteria BAE76551 http://www.ensemblgenomes.org/id/BAE76551 EnsemblBacteria b1931 http://www.ensemblgenomes.org/id/b1931 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 Gene3D 3.90.1680.10 http://www.cathdb.info/version/latest/superfamily/3.90.1680.10 GeneID 946435 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946435 HOGENOM HOG000104694 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000104694&db=HOGENOM6 InParanoid P76318 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76318 IntAct P76318 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76318* IntEnz 3.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4 InterPro IPR003738 http://www.ebi.ac.uk/interpro/entry/IPR003738 KEGG_Gene ecj:JW1916 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1916 KEGG_Gene eco:b1931 http://www.genome.jp/dbget-bin/www_bget?eco:b1931 OMA CGRFVIT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CGRFVIT PANTHER PTHR13604 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13604 PDB 2ICU http://www.ebi.ac.uk/pdbe-srv/view/entry/2ICU PDBsum 2ICU http://www.ebi.ac.uk/pdbsum/2ICU PSORT swissprot:YEDK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEDK_ECOLI PSORT-B swissprot:YEDK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEDK_ECOLI PSORT2 swissprot:YEDK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEDK_ECOLI Pfam PF02586 http://pfam.xfam.org/family/PF02586 Phobius swissprot:YEDK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEDK_ECOLI PhylomeDB P76318 http://phylomedb.org/?seqid=P76318 ProteinModelPortal P76318 http://www.proteinmodelportal.org/query/uniprot/P76318 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 23945014 http://www.ncbi.nlm.nih.gov/pubmed/23945014 PubMed 8371104 http://www.ncbi.nlm.nih.gov/pubmed/8371104 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000334583 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000334583 RefSeq YP_025310 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_025310 SMR P76318 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76318 STRING 511145.b1931 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1931&targetmode=cogs SUPFAM SSF143081 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF143081 UniProtKB YEDK_ECOLI http://www.uniprot.org/uniprot/YEDK_ECOLI UniProtKB-AC P76318 http://www.uniprot.org/uniprot/P76318 charge swissprot:YEDK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEDK_ECOLI eggNOG COG2135 http://eggnogapi.embl.de/nog_data/html/tree/COG2135 eggNOG ENOG4108RAV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108RAV epestfind swissprot:YEDK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEDK_ECOLI garnier swissprot:YEDK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEDK_ECOLI helixturnhelix swissprot:YEDK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEDK_ECOLI hmoment swissprot:YEDK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEDK_ECOLI iep swissprot:YEDK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEDK_ECOLI inforesidue swissprot:YEDK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEDK_ECOLI octanol swissprot:YEDK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEDK_ECOLI pepcoil swissprot:YEDK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEDK_ECOLI pepdigest swissprot:YEDK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEDK_ECOLI pepinfo swissprot:YEDK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEDK_ECOLI pepnet swissprot:YEDK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEDK_ECOLI pepstats swissprot:YEDK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEDK_ECOLI pepwheel swissprot:YEDK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEDK_ECOLI pepwindow swissprot:YEDK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEDK_ECOLI sigcleave swissprot:YEDK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEDK_ECOLI ## Database ID URL or Descriptions # AltName GLPX2_ECOLI D-fructose-1,6-bisphosphate 1-phosphohydrolase 2 class 2 # BIOPHYSICOCHEMICAL PROPERTIES GLPX2_ECOLI Kinetic parameters KM=100 uM for fructose 1,6-bisphosphate {ECO 0000269|PubMed 19073594}; KM=1 mM for Mn(2+) {ECO 0000269|PubMed 19073594}; Vmax=4.0 umol/min/mg enzyme {ECO 0000269|PubMed 19073594}; Note=The catalytic efficiency of YggF is 3-fold lower than that of GlpX, the other FBPase class 2 in E.coli.; pH dependence Optimum pH is 7.5-8. {ECO 0000269|PubMed 19073594}; # BRENDA 3.1.3.11 2026 # BioGrid 4262334 128 # CATALYTIC ACTIVITY D-fructose 1,6-bisphosphate + H(2)O = D- fructose 6-phosphate + phosphate. {ECO:0000269|PubMed 19073594}. # CDD cd01516 FBPase_glpX # COFACTOR GLPX2_ECOLI Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 19073594}; Note=Manganese. Mg(2+), Co(2+), Ni(2+), Ca(2+), Cu(2+) and Zn(2+) cannot support activity. {ECO 0000269|PubMed 19073594}; # ENZYME REGULATION Competitively inhibited by low concentrations of phosphate (IC50 of 1.2 mM) and is also sensitive to Li(+) (IC50 of 15.8 mM). Also inhibited by 1 mM ATP or 50 mM KCl (60% and 20% residual activity, respectively). Slightly activated (40-50%) by the addition of 1 mM dithiothreitol in vitro. {ECO:0000269|PubMed 19073594}. # EcoGene EG11245 yggF # FUNCTION GLPX2_ECOLI Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate. Also displays a low activity toward glucose 1,6-bisphosphate, and no activity against ribulose 1,5- bisphosphate, fructose 2,6-bisphosphate, or fructose 1-phosphate. {ECO 0000269|PubMed 19073594}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0030145 manganese ion binding; IDA:EcoCyc. # GO_function GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity; IDA:EcoCyc. # GO_process GO:0006071 glycerol metabolic process; IEA:InterPro. # GO_process GO:0006094 gluconeogenesis; IBA:GO_Central. # GO_process GO:0030388 fructose 1,6-bisphosphate metabolic process; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # IntAct P21437 6 # InterPro IPR004464 FBPase_class-2/SBPase # MISCELLANEOUS GLPX2_ECOLI E.coli K12 also possesses a FBPase class 1 (Fbp), which is the primary FBPase in E.coli and probably represents the main gluconeogenic FBPase. # Organism GLPX2_ECOLI Escherichia coli (strain K12) # PATRIC 32121274 VBIEscCol129921_3025 # PIR A65078 QQEC15 # PIRSF PIRSF004532 GlpX # Pfam PF03320 FBPase_glpX # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLPX2_ECOLI Fructose-1,6-bisphosphatase 2 class 2 # RefSeq NP_417405 NC_000913.3 # RefSeq WP_000987283 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA32600.1; Type=Frameshift; Positions=219; Evidence={ECO 0000305}; # SIMILARITY Belongs to the FBPase class 2 family. {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 19073594}. # TIGRFAMs TIGR00330 glpX # eggNOG COG1494 LUCA # eggNOG ENOG4108Q8A Bacteria BLAST swissprot:GLPX2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLPX2_ECOLI BioCyc ECOL316407:JW2897-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2897-MONOMER BioCyc EcoCyc:EG11245-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11245-MONOMER BioCyc MetaCyc:EG11245-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11245-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M808186200 http://dx.doi.org/10.1074/jbc.M808186200 DOI 10.1111/j.1365-2958.1989.tb00221.x http://dx.doi.org/10.1111/j.1365-2958.1989.tb00221.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.3.11 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.11 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EMBL X14436 http://www.ebi.ac.uk/ena/data/view/X14436 ENZYME 3.1.3.11 http://enzyme.expasy.org/EC/3.1.3.11 EchoBASE EB1226 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1226 EcoGene EG11245 http://www.ecogene.org/geneInfo.php?eg_id=EG11245 EnsemblBacteria AAC75967 http://www.ensemblgenomes.org/id/AAC75967 EnsemblBacteria AAC75967 http://www.ensemblgenomes.org/id/AAC75967 EnsemblBacteria BAE76994 http://www.ensemblgenomes.org/id/BAE76994 EnsemblBacteria BAE76994 http://www.ensemblgenomes.org/id/BAE76994 EnsemblBacteria BAE76994 http://www.ensemblgenomes.org/id/BAE76994 EnsemblBacteria b2930 http://www.ensemblgenomes.org/id/b2930 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_function GO:0042132 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042132 GO_process GO:0006071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006071 GO_process GO:0006094 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006094 GO_process GO:0030388 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030388 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 947410 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947410 HOGENOM HOG000241252 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000241252&db=HOGENOM6 InParanoid P21437 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P21437 IntAct P21437 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P21437* IntEnz 3.1.3.11 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.11 InterPro IPR004464 http://www.ebi.ac.uk/interpro/entry/IPR004464 KEGG_Gene ecj:JW2897 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2897 KEGG_Gene eco:b2930 http://www.genome.jp/dbget-bin/www_bget?eco:b2930 OMA RTCNIID http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RTCNIID PSORT swissprot:GLPX2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLPX2_ECOLI PSORT-B swissprot:GLPX2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLPX2_ECOLI PSORT2 swissprot:GLPX2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLPX2_ECOLI Pfam PF03320 http://pfam.xfam.org/family/PF03320 Phobius swissprot:GLPX2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLPX2_ECOLI PhylomeDB P21437 http://phylomedb.org/?seqid=P21437 ProteinModelPortal P21437 http://www.proteinmodelportal.org/query/uniprot/P21437 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19073594 http://www.ncbi.nlm.nih.gov/pubmed/19073594 PubMed 2546007 http://www.ncbi.nlm.nih.gov/pubmed/2546007 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417405 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417405 RefSeq WP_000987283 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000987283 SMR P21437 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P21437 STRING 511145.b2930 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2930&targetmode=cogs TIGRFAMs TIGR00330 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00330 UniProtKB GLPX2_ECOLI http://www.uniprot.org/uniprot/GLPX2_ECOLI UniProtKB-AC P21437 http://www.uniprot.org/uniprot/P21437 charge swissprot:GLPX2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLPX2_ECOLI eggNOG COG1494 http://eggnogapi.embl.de/nog_data/html/tree/COG1494 eggNOG ENOG4108Q8A http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Q8A epestfind swissprot:GLPX2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLPX2_ECOLI garnier swissprot:GLPX2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLPX2_ECOLI helixturnhelix swissprot:GLPX2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLPX2_ECOLI hmoment swissprot:GLPX2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLPX2_ECOLI iep swissprot:GLPX2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLPX2_ECOLI inforesidue swissprot:GLPX2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLPX2_ECOLI octanol swissprot:GLPX2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLPX2_ECOLI pepcoil swissprot:GLPX2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLPX2_ECOLI pepdigest swissprot:GLPX2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLPX2_ECOLI pepinfo swissprot:GLPX2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLPX2_ECOLI pepnet swissprot:GLPX2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLPX2_ECOLI pepstats swissprot:GLPX2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLPX2_ECOLI pepwheel swissprot:GLPX2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLPX2_ECOLI pepwindow swissprot:GLPX2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLPX2_ECOLI sigcleave swissprot:GLPX2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLPX2_ECOLI ## Database ID URL or Descriptions # AltName AK3_ECOLI Aspartate kinase III # AltName AK3_ECOLI Lysine-sensitive aspartokinase III # BioGrid 4261955 8 # CATALYTIC ACTIVITY AK3_ECOLI ATP + L-aspartate = ADP + 4-phospho-L- aspartate. # ENZYME REGULATION Synthesis and activity are sensitive to the allosteric inhibitor lysine, one of the end metabolites of the aspartic acid family branched pathway. {ECO:0000269|PubMed 16905770}. # EcoGene EG10550 lysC # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004072 aspartate kinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016597 amino acid binding; IEA:InterPro. # GO_process GO:0009089 lysine biosynthetic process via diaminopimelate; IDA:EcoCyc. # GO_process GO:0009090 homoserine biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.1160.10 -; 2. # InterPro IPR001048 Asp/Glu/Uridylate_kinase # InterPro IPR001341 Asp_kinase_dom # InterPro IPR002912 ACT_dom # InterPro IPR005260 Asp_kin_monofn # InterPro IPR018042 Aspartate_kinase_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00260 Glycine, serine and threonine metabolism # KEGG_Pathway ko00270 Cysteine and methionine metabolism # KEGG_Pathway ko00300 Lysine biosynthesis # MISCELLANEOUS AK3_ECOLI Aspartokinases I and II also catalyze the same reaction(s). # Organism AK3_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate step 1/4. # PATRIC 32123577 VBIEscCol129921_4137 # PDB 2J0W X-ray; 2.50 A; A=1-449 # PDB 2J0X X-ray; 2.80 A; A/B=1-449 # PIR G65209 KIECD3 # PIRSF PIRSF000726 Asp_kin # PROSITE PS00324 ASPARTOKINASE # PROSITE PS51671 ACT # Pfam PF00696 AA_kinase # Pfam PF01842 ACT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AK3_ECOLI Lysine-sensitive aspartokinase 3 # RefSeq NP_418448 NC_000913.3 # RefSeq WP_001290310 NZ_LN832404.1 # SIMILARITY Belongs to the aspartokinase family. {ECO 0000305}. # SIMILARITY Contains 1 ACT domain. {ECO:0000255|PROSITE- ProRule PRU01007}. # SUBUNIT AK3_ECOLI Homodimer. In the inactive form a homotetramer is formed. {ECO 0000269|PubMed 14623187, ECO 0000269|PubMed 16905770}. # SUPFAM SSF53633 SSF53633 # TIGRFAMs TIGR00656 asp_kin_monofn # TIGRFAMs TIGR00657 asp_kinases # UniPathway UPA00034 UER00015 # eggNOG COG0527 LUCA # eggNOG ENOG4105CFH Bacteria BLAST swissprot:AK3_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AK3_ECOLI BioCyc ECOL316407:JW3984-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3984-MONOMER BioCyc EcoCyc:ASPKINIII-MONOMER http://biocyc.org/getid?id=EcoCyc:ASPKINIII-MONOMER BioCyc MetaCyc:ASPKINIII-MONOMER http://biocyc.org/getid?id=MetaCyc:ASPKINIII-MONOMER COG COG0527 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0527 DOI 10.1016/j.jmb.2003.09.038 http://dx.doi.org/10.1016/j.jmb.2003.09.038 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M605886200 http://dx.doi.org/10.1074/jbc.M605886200 DOI 10.1093/nar/11.18.6157 http://dx.doi.org/10.1093/nar/11.18.6157 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.2.4 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.2.4 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M11812 http://www.ebi.ac.uk/ena/data/view/M11812 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X00008 http://www.ebi.ac.uk/ena/data/view/X00008 ENZYME 2.7.2.4 http://enzyme.expasy.org/EC/2.7.2.4 EchoBASE EB0545 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0545 EcoGene EG10550 http://www.ecogene.org/geneInfo.php?eg_id=EG10550 EnsemblBacteria AAC76994 http://www.ensemblgenomes.org/id/AAC76994 EnsemblBacteria AAC76994 http://www.ensemblgenomes.org/id/AAC76994 EnsemblBacteria BAE78026 http://www.ensemblgenomes.org/id/BAE78026 EnsemblBacteria BAE78026 http://www.ensemblgenomes.org/id/BAE78026 EnsemblBacteria BAE78026 http://www.ensemblgenomes.org/id/BAE78026 EnsemblBacteria b4024 http://www.ensemblgenomes.org/id/b4024 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004072 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004072 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016597 GO_process GO:0009089 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009089 GO_process GO:0009090 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009090 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.1160.10 http://www.cathdb.info/version/latest/superfamily/3.40.1160.10 GeneID 948531 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948531 HOGENOM HOG000293094 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000293094&db=HOGENOM6 InParanoid P08660 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P08660 IntEnz 2.7.2.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.2.4 InterPro IPR001048 http://www.ebi.ac.uk/interpro/entry/IPR001048 InterPro IPR001341 http://www.ebi.ac.uk/interpro/entry/IPR001341 InterPro IPR002912 http://www.ebi.ac.uk/interpro/entry/IPR002912 InterPro IPR005260 http://www.ebi.ac.uk/interpro/entry/IPR005260 InterPro IPR018042 http://www.ebi.ac.uk/interpro/entry/IPR018042 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3984 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3984 KEGG_Gene eco:b4024 http://www.genome.jp/dbget-bin/www_bget?eco:b4024 KEGG_Orthology KO:K00928 http://www.genome.jp/dbget-bin/www_bget?KO:K00928 KEGG_Pathway ko00260 http://www.genome.jp/kegg-bin/show_pathway?ko00260 KEGG_Pathway ko00270 http://www.genome.jp/kegg-bin/show_pathway?ko00270 KEGG_Pathway ko00300 http://www.genome.jp/kegg-bin/show_pathway?ko00300 KEGG_Reaction rn:R00480 http://www.genome.jp/dbget-bin/www_bget?rn:R00480 OMA MICFGAN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MICFGAN PDB 2J0W http://www.ebi.ac.uk/pdbe-srv/view/entry/2J0W PDB 2J0X http://www.ebi.ac.uk/pdbe-srv/view/entry/2J0X PDBsum 2J0W http://www.ebi.ac.uk/pdbsum/2J0W PDBsum 2J0X http://www.ebi.ac.uk/pdbsum/2J0X PROSITE PS00324 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00324 PROSITE PS51671 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51671 PSORT swissprot:AK3_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AK3_ECOLI PSORT-B swissprot:AK3_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AK3_ECOLI PSORT2 swissprot:AK3_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AK3_ECOLI Pfam PF00696 http://pfam.xfam.org/family/PF00696 Pfam PF01842 http://pfam.xfam.org/family/PF01842 Phobius swissprot:AK3_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AK3_ECOLI PhylomeDB P08660 http://phylomedb.org/?seqid=P08660 ProteinModelPortal P08660 http://www.proteinmodelportal.org/query/uniprot/P08660 PubMed 14623187 http://www.ncbi.nlm.nih.gov/pubmed/14623187 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16905770 http://www.ncbi.nlm.nih.gov/pubmed/16905770 PubMed 3003049 http://www.ncbi.nlm.nih.gov/pubmed/3003049 PubMed 6312411 http://www.ncbi.nlm.nih.gov/pubmed/6312411 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418448 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418448 RefSeq WP_001290310 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001290310 SMR P08660 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P08660 STRING 511145.b4024 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4024&targetmode=cogs STRING COG0527 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0527&targetmode=cogs SUPFAM SSF53633 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53633 TIGRFAMs TIGR00656 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00656 TIGRFAMs TIGR00657 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00657 UniProtKB AK3_ECOLI http://www.uniprot.org/uniprot/AK3_ECOLI UniProtKB-AC P08660 http://www.uniprot.org/uniprot/P08660 charge swissprot:AK3_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AK3_ECOLI eggNOG COG0527 http://eggnogapi.embl.de/nog_data/html/tree/COG0527 eggNOG ENOG4105CFH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CFH epestfind swissprot:AK3_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AK3_ECOLI garnier swissprot:AK3_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AK3_ECOLI helixturnhelix swissprot:AK3_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AK3_ECOLI hmoment swissprot:AK3_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AK3_ECOLI iep swissprot:AK3_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AK3_ECOLI inforesidue swissprot:AK3_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AK3_ECOLI octanol swissprot:AK3_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AK3_ECOLI pepcoil swissprot:AK3_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AK3_ECOLI pepdigest swissprot:AK3_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AK3_ECOLI pepinfo swissprot:AK3_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AK3_ECOLI pepnet swissprot:AK3_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AK3_ECOLI pepstats swissprot:AK3_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AK3_ECOLI pepwheel swissprot:AK3_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AK3_ECOLI pepwindow swissprot:AK3_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AK3_ECOLI sigcleave swissprot:AK3_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AK3_ECOLI ## Database ID URL or Descriptions # BioGrid 4261589 13 # EcoGene EG11690 yicN # InterPro IPR009587 DUF1198 # Organism YICN_ECOLI Escherichia coli (strain K12) # PATRIC 32122819 VBIEscCol129921_3785 # PIR H65167 H65167 # Pfam PF06711 DUF1198 # ProDom PD093913 DUF1198 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YICN_ECOLI Uncharacterized protein YicN # RefSeq NP_418119 NC_000913.3 # RefSeq WP_001295241 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA62015.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # eggNOG ENOG4108SAJ Bacteria # eggNOG ENOG4111H7S LUCA BLAST swissprot:YICN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YICN_ECOLI BioCyc ECOL316407:JW5637-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5637-MONOMER BioCyc EcoCyc:EG11690-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11690-MONOMER DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1641 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1641 EcoGene EG11690 http://www.ecogene.org/geneInfo.php?eg_id=EG11690 EnsemblBacteria AAC76686 http://www.ensemblgenomes.org/id/AAC76686 EnsemblBacteria AAC76686 http://www.ensemblgenomes.org/id/AAC76686 EnsemblBacteria BAE77630 http://www.ensemblgenomes.org/id/BAE77630 EnsemblBacteria BAE77630 http://www.ensemblgenomes.org/id/BAE77630 EnsemblBacteria BAE77630 http://www.ensemblgenomes.org/id/BAE77630 EnsemblBacteria b3663 http://www.ensemblgenomes.org/id/b3663 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 948173 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948173 HOGENOM HOG000126282 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126282&db=HOGENOM6 InterPro IPR009587 http://www.ebi.ac.uk/interpro/entry/IPR009587 KEGG_Gene ecj:JW5637 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5637 KEGG_Gene eco:b3663 http://www.genome.jp/dbget-bin/www_bget?eco:b3663 OMA LESMIDQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LESMIDQ PSORT swissprot:YICN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YICN_ECOLI PSORT-B swissprot:YICN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YICN_ECOLI PSORT2 swissprot:YICN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YICN_ECOLI Pfam PF06711 http://pfam.xfam.org/family/PF06711 Phobius swissprot:YICN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YICN_ECOLI ProteinModelPortal P0ADL3 http://www.proteinmodelportal.org/query/uniprot/P0ADL3 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418119 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418119 RefSeq WP_001295241 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295241 STRING 511145.b3663 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3663&targetmode=cogs UniProtKB YICN_ECOLI http://www.uniprot.org/uniprot/YICN_ECOLI UniProtKB-AC P0ADL3 http://www.uniprot.org/uniprot/P0ADL3 charge swissprot:YICN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YICN_ECOLI eggNOG ENOG4108SAJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108SAJ eggNOG ENOG4111H7S http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111H7S epestfind swissprot:YICN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YICN_ECOLI garnier swissprot:YICN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YICN_ECOLI helixturnhelix swissprot:YICN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YICN_ECOLI hmoment swissprot:YICN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YICN_ECOLI iep swissprot:YICN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YICN_ECOLI inforesidue swissprot:YICN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YICN_ECOLI octanol swissprot:YICN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YICN_ECOLI pepcoil swissprot:YICN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YICN_ECOLI pepdigest swissprot:YICN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YICN_ECOLI pepinfo swissprot:YICN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YICN_ECOLI pepnet swissprot:YICN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YICN_ECOLI pepstats swissprot:YICN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YICN_ECOLI pepwheel swissprot:YICN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YICN_ECOLI pepwindow swissprot:YICN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YICN_ECOLI sigcleave swissprot:YICN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YICN_ECOLI ## Database ID URL or Descriptions # BioGrid 4261592 197 # DISRUPTION PHENOTYPE FTSN_ECOLI Depletion does not affect localization of FtsZ, FtsA, ZipA, FtsQ, FtsL and FtsI to the division site (PubMed 11703663). Cells containing low levels of FtsN stop dividing while their mean cell length increases (PubMed 20345660). Absence of FtsN is followed by an inverse sequential disassembly of already assembled divisome compounds (PubMed 20345660). {ECO 0000269|PubMed 11703663, ECO 0000269|PubMed 20345660}. # DOMAIN FTSN_ECOLI The cytoplasmic region is required for interaction with FtsA (PubMed 24750258). The periplasmic region is composed of a membrane-proximal region containing three short partially formed helices (H1, H2 and H3), followed by an unstructured glutamine- rich linker, and a C-terminal globular SPOR domain (PubMed 15101973, PubMed 19684127). Essential function of FtsN is accomplished by a small region of at most 35 residues that is centered about the H2 helix (PubMed 19684127). The SPOR domain, which exhibits a ribonucleoprotein (RNP) fold, binds peptidoglycan and is a strong septal localization determinant, but it seems not essential for cell division (PubMed 15466024, PubMed 19684127, PubMed 24056104). {ECO 0000269|PubMed 15101973, ECO 0000269|PubMed 15466024, ECO 0000269|PubMed 19684127, ECO 0000269|PubMed 24056104, ECO 0000269|PubMed 24750258}. # EcoGene EG11529 ftsN # FUNCTION FTSN_ECOLI Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases (Probable) (PubMed 25496160). Required for full FtsI activity (PubMed 25496160). Required for recruitment of AmiC to the septal ring (PubMed 12787347). {ECO 0000269|PubMed 12787347, ECO 0000269|PubMed 25496160, ECO 0000305|PubMed 25496050, ECO 0000305|PubMed 25571948}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IEA:UniProtKB-HAMAP. # GO_component GO:0030428 cell septum; IDA:EcoCyc. # GO_component GO:0032153 cell division site; IEA:UniProtKB-HAMAP. # GO_function GO:0042834 peptidoglycan binding; IEA:InterPro. # GO_process GO:0000917 barrier septum assembly; IMP:EcoCyc. # GO_process GO:0043093 FtsZ-dependent cytokinesis; IEA:UniProtKB-HAMAP. # GO_process GO:0051301 cell division; IDA:CACAO. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0008150 biological_process # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0051301 cell division # Gene3D 3.30.70.1070 -; 1. # HAMAP MF_02039 FtsN_entero # INTERACTION FTSN_ECOLI P56976 blr; NbExp=3; IntAct=EBI-1134233, EBI-6419495; P0ABH0 ftsA; NbExp=7; IntAct=EBI-1134233, EBI-550562; P0AD68 ftsI; NbExp=3; IntAct=EBI-1134233, EBI-548564; P06136 ftsQ; NbExp=7; IntAct=EBI-1134233, EBI-1130157; P0ABG4 ftsW; NbExp=3; IntAct=EBI-1134233, EBI-1214767; P02919 mrcB; NbExp=6; IntAct=EBI-1134233, EBI-909769; # IntAct P29131 24 # InterPro IPR007730 SPOR_dom # InterPro IPR011930 FtsN # KEGG_Brite ko03036 Chromosome # Organism FTSN_ECOLI Escherichia coli (strain K12) # PATRIC 32123381 VBIEscCol129921_4051 # PDB 1UTA NMR; -; A=243-319 # PIR S40876 S40876 # PROSITE PS51724 SPOR # Pfam PF05036 SPOR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Cell division protein FtsN {ECO:0000255|HAMAP-Rule MF_02039, ECO:0000305} # RefSeq NP_418368 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA23935.1; Type=Frameshift; Positions=Several; Evidence={ECO 0000305}; # SIMILARITY Belongs to the FtsN family. {ECO:0000255|HAMAP- Rule MF_02039, ECO:0000305}. # SIMILARITY Contains 1 SPOR domain. {ECO:0000255|HAMAP- Rule MF_02039}. # SUBCELLULAR LOCATION FTSN_ECOLI Cell inner membrane {ECO 0000269|PubMed 8631709}; Single-pass type II membrane protein {ECO 0000269|PubMed 8631709}. Note=Localizes to the septum (PubMed 9282742, PubMed 19684127, PubMed 24750258). Localizes to the midcell via interaction with the early cell division protein FtsA and via the periplasmic SPOR domain (PubMed 9282742, PubMed 19684127, PubMed 24750258). FtsA-dependent localization precedes SPOR-dependent localization, and both are needed for efficient localization (PubMed 24750258). Localization depends upon FtsZ, FtsA, ZipA, FtsQ and FtsI (PubMed 9282742, PubMed 11948172). {ECO 0000269|PubMed 11948172, ECO 0000269|PubMed 19684127, ECO 0000269|PubMed 24750258, ECO 0000269|PubMed 9282742}. # SUBUNIT FTSN_ECOLI Interacts with FtsA via its N-terminal cytoplasmic domain (PubMed 22328664, PubMed 24750258, PubMed 25496160, PubMed 25496259). Interacts with ZapA, FtsQ, FtsW and FtsI (PubMed 17185541, PubMed 20497333). {ECO 0000269|PubMed 17185541, ECO 0000269|PubMed 20497333, ECO 0000269|PubMed 22328664, ECO 0000269|PubMed 24750258, ECO 0000269|PubMed 25496160, ECO 0000269|PubMed 25496259}. # SUPFAM SSF110997 SSF110997 # TIGRFAMs TIGR02223 ftsN # eggNOG COG3087 LUCA # eggNOG ENOG41063M6 Bacteria BLAST swissprot:FTSN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FTSN_ECOLI BioCyc ECOL316407:JW3904-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3904-MONOMER BioCyc EcoCyc:EG11529-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11529-MONOMER BioCyc MetaCyc:EG11529-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11529-MONOMER COG COG3087 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3087 DIP DIP-9705N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9705N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1997.4641833.x http://dx.doi.org/10.1046/j.1365-2958.1997.4641833.x DOI 10.1046/j.1365-2958.2001.02640.x http://dx.doi.org/10.1046/j.1365-2958.2001.02640.x DOI 10.1046/j.1365-2958.2003.03511.x http://dx.doi.org/10.1046/j.1365-2958.2003.03511.x DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1099/mic.0.2006/000265-0 http://dx.doi.org/10.1099/mic.0.2006/000265-0 DOI 10.1111/j.1365-2958.2004.03991.x http://dx.doi.org/10.1111/j.1365-2958.2004.03991.x DOI 10.1111/j.1365-2958.2010.07134.x http://dx.doi.org/10.1111/j.1365-2958.2010.07134.x DOI 10.1111/j.1365-2958.2010.07211.x http://dx.doi.org/10.1111/j.1365-2958.2010.07211.x DOI 10.1111/mmi.12623 http://dx.doi.org/10.1111/mmi.12623 DOI 10.1111/mmi.12905 http://dx.doi.org/10.1111/mmi.12905 DOI 10.1111/mmi.12906 http://dx.doi.org/10.1111/mmi.12906 DOI 10.1111/mmi.12907 http://dx.doi.org/10.1111/mmi.12907 DOI 10.1111/mmi.12925 http://dx.doi.org/10.1111/mmi.12925 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00811-09 http://dx.doi.org/10.1128/JB.00811-09 DOI 10.1128/JB.00911-13 http://dx.doi.org/10.1128/JB.00911-13 DOI 10.1128/JB.06683-11 http://dx.doi.org/10.1128/JB.06683-11 DOI 10.1128/JB.184.9.2552-2556.2002 http://dx.doi.org/10.1128/JB.184.9.2552-2556.2002 DOI 10.1128/JB.186.20.6728-6737.2004 http://dx.doi.org/10.1128/JB.186.20.6728-6737.2004 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L06547 http://www.ebi.ac.uk/ena/data/view/L06547 EMBL L14281 http://www.ebi.ac.uk/ena/data/view/L14281 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1491 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1491 EcoGene EG11529 http://www.ecogene.org/geneInfo.php?eg_id=EG11529 EnsemblBacteria AAC76915 http://www.ensemblgenomes.org/id/AAC76915 EnsemblBacteria AAC76915 http://www.ensemblgenomes.org/id/AAC76915 EnsemblBacteria BAE77377 http://www.ensemblgenomes.org/id/BAE77377 EnsemblBacteria BAE77377 http://www.ensemblgenomes.org/id/BAE77377 EnsemblBacteria BAE77377 http://www.ensemblgenomes.org/id/BAE77377 EnsemblBacteria b3933 http://www.ensemblgenomes.org/id/b3933 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0030428 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030428 GO_component GO:0032153 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032153 GO_function GO:0042834 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042834 GO_process GO:0000917 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000917 GO_process GO:0043093 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043093 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 Gene3D 3.30.70.1070 http://www.cathdb.info/version/latest/superfamily/3.30.70.1070 GeneID 948428 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948428 HAMAP MF_02039 http://hamap.expasy.org/unirule/MF_02039 HOGENOM HOG000126695 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126695&db=HOGENOM6 InParanoid P29131 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P29131 IntAct P29131 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P29131* InterPro IPR007730 http://www.ebi.ac.uk/interpro/entry/IPR007730 InterPro IPR011930 http://www.ebi.ac.uk/interpro/entry/IPR011930 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene ecj:JW3904 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3904 KEGG_Gene eco:b3933 http://www.genome.jp/dbget-bin/www_bget?eco:b3933 KEGG_Orthology KO:K03591 http://www.genome.jp/dbget-bin/www_bget?KO:K03591 OMA LYFIAHN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LYFIAHN PDB 1UTA http://www.ebi.ac.uk/pdbe-srv/view/entry/1UTA PDBsum 1UTA http://www.ebi.ac.uk/pdbsum/1UTA PROSITE PS51724 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51724 PSORT swissprot:FTSN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FTSN_ECOLI PSORT-B swissprot:FTSN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FTSN_ECOLI PSORT2 swissprot:FTSN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FTSN_ECOLI Pfam PF05036 http://pfam.xfam.org/family/PF05036 Phobius swissprot:FTSN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FTSN_ECOLI ProteinModelPortal P29131 http://www.proteinmodelportal.org/query/uniprot/P29131 PubMed 11703663 http://www.ncbi.nlm.nih.gov/pubmed/11703663 PubMed 11948172 http://www.ncbi.nlm.nih.gov/pubmed/11948172 PubMed 12787347 http://www.ncbi.nlm.nih.gov/pubmed/12787347 PubMed 15101973 http://www.ncbi.nlm.nih.gov/pubmed/15101973 PubMed 15466024 http://www.ncbi.nlm.nih.gov/pubmed/15466024 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17185541 http://www.ncbi.nlm.nih.gov/pubmed/17185541 PubMed 19684127 http://www.ncbi.nlm.nih.gov/pubmed/19684127 PubMed 20345660 http://www.ncbi.nlm.nih.gov/pubmed/20345660 PubMed 20497333 http://www.ncbi.nlm.nih.gov/pubmed/20497333 PubMed 22328664 http://www.ncbi.nlm.nih.gov/pubmed/22328664 PubMed 24056104 http://www.ncbi.nlm.nih.gov/pubmed/24056104 PubMed 24750258 http://www.ncbi.nlm.nih.gov/pubmed/24750258 PubMed 25496050 http://www.ncbi.nlm.nih.gov/pubmed/25496050 PubMed 25496160 http://www.ncbi.nlm.nih.gov/pubmed/25496160 PubMed 25496259 http://www.ncbi.nlm.nih.gov/pubmed/25496259 PubMed 25571948 http://www.ncbi.nlm.nih.gov/pubmed/25571948 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 8509333 http://www.ncbi.nlm.nih.gov/pubmed/8509333 PubMed 8631709 http://www.ncbi.nlm.nih.gov/pubmed/8631709 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9282742 http://www.ncbi.nlm.nih.gov/pubmed/9282742 RefSeq NP_418368 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418368 SMR P29131 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P29131 STRING 511145.b3933 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3933&targetmode=cogs STRING COG3087 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3087&targetmode=cogs SUPFAM SSF110997 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF110997 TIGRFAMs TIGR02223 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02223 UniProtKB FTSN_ECOLI http://www.uniprot.org/uniprot/FTSN_ECOLI UniProtKB-AC P29131 http://www.uniprot.org/uniprot/P29131 charge swissprot:FTSN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FTSN_ECOLI eggNOG COG3087 http://eggnogapi.embl.de/nog_data/html/tree/COG3087 eggNOG ENOG41063M6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41063M6 epestfind swissprot:FTSN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FTSN_ECOLI garnier swissprot:FTSN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FTSN_ECOLI helixturnhelix swissprot:FTSN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FTSN_ECOLI hmoment swissprot:FTSN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FTSN_ECOLI iep swissprot:FTSN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FTSN_ECOLI inforesidue swissprot:FTSN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FTSN_ECOLI octanol swissprot:FTSN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FTSN_ECOLI pepcoil swissprot:FTSN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FTSN_ECOLI pepdigest swissprot:FTSN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FTSN_ECOLI pepinfo swissprot:FTSN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FTSN_ECOLI pepnet swissprot:FTSN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FTSN_ECOLI pepstats swissprot:FTSN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FTSN_ECOLI pepwheel swissprot:FTSN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FTSN_ECOLI pepwindow swissprot:FTSN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FTSN_ECOLI sigcleave swissprot:FTSN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FTSN_ECOLI ## Database ID URL or Descriptions # BioGrid 4259507 170 # EcoGene EG11991 yehE # InterPro IPR020386 Uncharacterised_YehE # Organism YEHE_ECOLI Escherichia coli (strain K12) # PATRIC 32119557 VBIEscCol129921_2189 # PIR G64978 G64978 # Pfam PF10836 DUF2574 # ProDom PD064930 Uncharacterised_YehE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEHE_ECOLI Uncharacterized protein YehE # RefSeq NP_416615 NC_000913.3 # RefSeq WP_001324851 NZ_LN832404.1 # eggNOG ENOG41067AK Bacteria # eggNOG ENOG4112CU3 LUCA BLAST swissprot:YEHE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEHE_ECOLI BioCyc ECOL316407:JW2099-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2099-MONOMER BioCyc EcoCyc:EG11991-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11991-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1934 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1934 EcoGene EG11991 http://www.ecogene.org/geneInfo.php?eg_id=EG11991 EnsemblBacteria AAC75173 http://www.ensemblgenomes.org/id/AAC75173 EnsemblBacteria AAC75173 http://www.ensemblgenomes.org/id/AAC75173 EnsemblBacteria BAE76590 http://www.ensemblgenomes.org/id/BAE76590 EnsemblBacteria BAE76590 http://www.ensemblgenomes.org/id/BAE76590 EnsemblBacteria BAE76590 http://www.ensemblgenomes.org/id/BAE76590 EnsemblBacteria b2112 http://www.ensemblgenomes.org/id/b2112 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946615 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946615 HOGENOM HOG000122143 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122143&db=HOGENOM6 InterPro IPR020386 http://www.ebi.ac.uk/interpro/entry/IPR020386 KEGG_Gene ecj:JW2099 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2099 KEGG_Gene eco:b2112 http://www.genome.jp/dbget-bin/www_bget?eco:b2112 OMA SETCSTD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SETCSTD PSORT swissprot:YEHE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEHE_ECOLI PSORT-B swissprot:YEHE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEHE_ECOLI PSORT2 swissprot:YEHE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEHE_ECOLI Pfam PF10836 http://pfam.xfam.org/family/PF10836 Phobius swissprot:YEHE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEHE_ECOLI ProteinModelPortal P33344 http://www.proteinmodelportal.org/query/uniprot/P33344 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416615 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416615 RefSeq WP_001324851 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001324851 STRING 511145.b2112 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2112&targetmode=cogs UniProtKB YEHE_ECOLI http://www.uniprot.org/uniprot/YEHE_ECOLI UniProtKB-AC P33344 http://www.uniprot.org/uniprot/P33344 charge swissprot:YEHE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEHE_ECOLI eggNOG ENOG41067AK http://eggnogapi.embl.de/nog_data/html/tree/ENOG41067AK eggNOG ENOG4112CU3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4112CU3 epestfind swissprot:YEHE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEHE_ECOLI garnier swissprot:YEHE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEHE_ECOLI helixturnhelix swissprot:YEHE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEHE_ECOLI hmoment swissprot:YEHE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEHE_ECOLI iep swissprot:YEHE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEHE_ECOLI inforesidue swissprot:YEHE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEHE_ECOLI octanol swissprot:YEHE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEHE_ECOLI pepcoil swissprot:YEHE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEHE_ECOLI pepdigest swissprot:YEHE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEHE_ECOLI pepinfo swissprot:YEHE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEHE_ECOLI pepnet swissprot:YEHE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEHE_ECOLI pepstats swissprot:YEHE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEHE_ECOLI pepwheel swissprot:YEHE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEHE_ECOLI pepwindow swissprot:YEHE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEHE_ECOLI sigcleave swissprot:YEHE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEHE_ECOLI ## Database ID URL or Descriptions # BioGrid 4262948 16 # EcoGene EG13528 ygaZ # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005304 L-valine transmembrane transporter activity; IMP:EcoCyc. # GO_function GO:0015562 efflux transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0015829 valine transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR011606 Brnchd-chn_aa_trnsp_permease # Organism YGAZ_ECOLI Escherichia coli (strain K12) # PATRIC 32120756 VBIEscCol129921_2775 # PIR C65048 C65048 # Pfam PF03591 AzlC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGAZ_ECOLI Inner membrane protein YgaZ # RefSeq NP_417167 NC_000913.3 # RefSeq WP_000445651 NZ_LN832404.1 # SIMILARITY Belongs to the AzlC family. {ECO 0000305}. # SUBCELLULAR LOCATION YGAZ_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.78.1 the branched chain amino acid exporter (liv-e) family # eggNOG COG1296 LUCA # eggNOG ENOG4108UMN Bacteria BLAST swissprot:YGAZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGAZ_ECOLI BioCyc ECOL316407:JW2657-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2657-MONOMER BioCyc EcoCyc:G7405-MONOMER http://biocyc.org/getid?id=EcoCyc:G7405-MONOMER BioCyc MetaCyc:G7405-MONOMER http://biocyc.org/getid?id=MetaCyc:G7405-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3299 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3299 EcoGene EG13528 http://www.ecogene.org/geneInfo.php?eg_id=EG13528 EnsemblBacteria AAC75729 http://www.ensemblgenomes.org/id/AAC75729 EnsemblBacteria AAC75729 http://www.ensemblgenomes.org/id/AAC75729 EnsemblBacteria BAE76784 http://www.ensemblgenomes.org/id/BAE76784 EnsemblBacteria BAE76784 http://www.ensemblgenomes.org/id/BAE76784 EnsemblBacteria BAE76784 http://www.ensemblgenomes.org/id/BAE76784 EnsemblBacteria b2682 http://www.ensemblgenomes.org/id/b2682 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005304 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005304 GO_function GO:0015562 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015562 GO_process GO:0015829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015829 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 945093 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945093 HOGENOM HOG000013807 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000013807&db=HOGENOM6 InParanoid P76630 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76630 InterPro IPR011606 http://www.ebi.ac.uk/interpro/entry/IPR011606 KEGG_Gene ecj:JW2657 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2657 KEGG_Gene eco:b2682 http://www.genome.jp/dbget-bin/www_bget?eco:b2682 OMA VELSFYD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VELSFYD PSORT swissprot:YGAZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGAZ_ECOLI PSORT-B swissprot:YGAZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGAZ_ECOLI PSORT2 swissprot:YGAZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGAZ_ECOLI Pfam PF03591 http://pfam.xfam.org/family/PF03591 Phobius swissprot:YGAZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGAZ_ECOLI PhylomeDB P76630 http://phylomedb.org/?seqid=P76630 ProteinModelPortal P76630 http://www.proteinmodelportal.org/query/uniprot/P76630 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417167 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417167 RefSeq WP_000445651 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000445651 STRING 511145.b2682 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2682&targetmode=cogs TCDB 2.A.78.1 http://www.tcdb.org/search/result.php?tc=2.A.78.1 UniProtKB YGAZ_ECOLI http://www.uniprot.org/uniprot/YGAZ_ECOLI UniProtKB-AC P76630 http://www.uniprot.org/uniprot/P76630 charge swissprot:YGAZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGAZ_ECOLI eggNOG COG1296 http://eggnogapi.embl.de/nog_data/html/tree/COG1296 eggNOG ENOG4108UMN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UMN epestfind swissprot:YGAZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGAZ_ECOLI garnier swissprot:YGAZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGAZ_ECOLI helixturnhelix swissprot:YGAZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGAZ_ECOLI hmoment swissprot:YGAZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGAZ_ECOLI iep swissprot:YGAZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGAZ_ECOLI inforesidue swissprot:YGAZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGAZ_ECOLI octanol swissprot:YGAZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGAZ_ECOLI pepcoil swissprot:YGAZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGAZ_ECOLI pepdigest swissprot:YGAZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGAZ_ECOLI pepinfo swissprot:YGAZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGAZ_ECOLI pepnet swissprot:YGAZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGAZ_ECOLI pepstats swissprot:YGAZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGAZ_ECOLI pepwheel swissprot:YGAZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGAZ_ECOLI pepwindow swissprot:YGAZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGAZ_ECOLI sigcleave swissprot:YGAZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGAZ_ECOLI ## Database ID URL or Descriptions # BioGrid 4263358 12 # CDD cd06261 TM_PBP2; 2 # EcoGene EG11573 thiP # FUNCTION THIP_ECOLI Part of the ABC transporter complex ThiBPQ involved in thiamine import. Probably responsible for the translocation of the substrate across the membrane. {ECO 0000269|PubMed 9535878}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005215 transporter activity; IEA:InterPro. # GO_process GO:0015888 thiamine transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006810 transport # Gene3D 1.10.3720.10 -; 2. # InterPro IPR000515 MetI-like # InterPro IPR005947 ThiP_ABC_transpt # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00191 Thiamine transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism THIP_ECOLI Escherichia coli (strain K12) # PATRIC 32115235 VBIEscCol129921_0069 # PIR C64728 C64728 # PROSITE PS50928 ABC_TM1; 2 # Pfam PF00528 BPD_transp_1; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName THIP_ECOLI Thiamine transport system permease protein ThiP # RefSeq NP_414609 NC_000913.3 # RefSeq WP_000235721 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. {ECO 0000305}. # SIMILARITY Contains 2 ABC transmembrane type-1 domains. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION THIP_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00441, ECO 0000269|PubMed 15919996}. # SUBUNIT The complex is composed of two ATP-binding proteins (ThiQ), two transmembrane proteins (ThiP) and a solute-binding protein (ThiB). {ECO 0000305}. # SUPFAM SSF161098 SSF161098; 2 # TCDB 3.A.1.19 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR01253 thiP # eggNOG COG1178 LUCA # eggNOG ENOG4106SMU Bacteria BLAST swissprot:THIP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:THIP_ECOLI BioCyc ECOL316407:JW0066-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0066-MONOMER BioCyc EcoCyc:SFUB-MONOMER http://biocyc.org/getid?id=EcoCyc:SFUB-MONOMER COG COG1178 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1178 DIP DIP-10989N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10989N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.273.15.8946 http://dx.doi.org/10.1074/jbc.273.15.8946 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1533 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1533 EcoGene EG11573 http://www.ecogene.org/geneInfo.php?eg_id=EG11573 EnsemblBacteria AAC73178 http://www.ensemblgenomes.org/id/AAC73178 EnsemblBacteria AAC73178 http://www.ensemblgenomes.org/id/AAC73178 EnsemblBacteria BAB96636 http://www.ensemblgenomes.org/id/BAB96636 EnsemblBacteria BAB96636 http://www.ensemblgenomes.org/id/BAB96636 EnsemblBacteria BAB96636 http://www.ensemblgenomes.org/id/BAB96636 EnsemblBacteria b0067 http://www.ensemblgenomes.org/id/b0067 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_process GO:0015888 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015888 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 944784 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944784 HOGENOM HOG000272487 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000272487&db=HOGENOM6 InParanoid P31549 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31549 IntAct P31549 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31549* InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 InterPro IPR005947 http://www.ebi.ac.uk/interpro/entry/IPR005947 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0066 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0066 KEGG_Gene eco:b0067 http://www.genome.jp/dbget-bin/www_bget?eco:b0067 KEGG_Orthology KO:K02063 http://www.genome.jp/dbget-bin/www_bget?KO:K02063 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA WTVRRRE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WTVRRRE PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:THIP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:THIP_ECOLI PSORT-B swissprot:THIP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:THIP_ECOLI PSORT2 swissprot:THIP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:THIP_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Phobius swissprot:THIP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:THIP_ECOLI PhylomeDB P31549 http://phylomedb.org/?seqid=P31549 ProteinModelPortal P31549 http://www.proteinmodelportal.org/query/uniprot/P31549 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9535878 http://www.ncbi.nlm.nih.gov/pubmed/9535878 RefSeq NP_414609 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414609 RefSeq WP_000235721 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000235721 SMR P31549 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31549 STRING 511145.b0067 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0067&targetmode=cogs STRING COG1178 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1178&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.19 http://www.tcdb.org/search/result.php?tc=3.A.1.19 TIGRFAMs TIGR01253 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01253 UniProtKB THIP_ECOLI http://www.uniprot.org/uniprot/THIP_ECOLI UniProtKB-AC P31549 http://www.uniprot.org/uniprot/P31549 charge swissprot:THIP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:THIP_ECOLI eggNOG COG1178 http://eggnogapi.embl.de/nog_data/html/tree/COG1178 eggNOG ENOG4106SMU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106SMU epestfind swissprot:THIP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:THIP_ECOLI garnier swissprot:THIP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:THIP_ECOLI helixturnhelix swissprot:THIP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:THIP_ECOLI hmoment swissprot:THIP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:THIP_ECOLI iep swissprot:THIP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:THIP_ECOLI inforesidue swissprot:THIP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:THIP_ECOLI octanol swissprot:THIP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:THIP_ECOLI pepcoil swissprot:THIP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:THIP_ECOLI pepdigest swissprot:THIP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:THIP_ECOLI pepinfo swissprot:THIP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:THIP_ECOLI pepnet swissprot:THIP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:THIP_ECOLI pepstats swissprot:THIP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:THIP_ECOLI pepwheel swissprot:THIP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:THIP_ECOLI pepwindow swissprot:THIP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:THIP_ECOLI sigcleave swissprot:THIP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:THIP_ECOLI ## Database ID URL or Descriptions # BioGrid 4260098 282 # DISRUPTION PHENOTYPE In a minCDE operon disruption (minC-minD- minE), cells divide not only at midpoint but also at their poles, yielding small minicells and long rods. Loss of polar localization of several polar-localized proteins including GroEL-GroES, TnaA and YqjD. {ECO:0000269|PubMed 22380631}. # EcoGene EG10596 minC # FUNCTION MINC_ECOLI Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization. {ECO 0000269|PubMed 22380631}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0060187 cell pole; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0000902 cell morphogenesis; IEA:InterPro. # GO_process GO:0032955 regulation of barrier septum assembly; IMP:EcoCyc. # GO_process GO:0051301 cell division; EXP:EcoliWiki. # GO_process GO:0051302 regulation of cell division; EXP:EcoliWiki. # GO_process GO:0090529 cell septum assembly; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0000902 cell morphogenesis # GOslim_process GO:0008150 biological_process # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0051301 cell division # Gene3D 2.160.20.70 -; 1. # HAMAP MF_00267 MinC # INTERACTION MINC_ECOLI P0AEJ8 eutN; NbExp=3; IntAct=EBI-554060, EBI-8767793; P00946 manA; NbExp=3; IntAct=EBI-554060, EBI-554045; P0AEZ3 minD; NbExp=6; IntAct=EBI-554060, EBI-554545; P39409 yjjW; NbExp=2; IntAct=EBI-554060, EBI-9132384; # IntAct P18196 32 # InterPro IPR005526 Septum_form_inhib_MinC_C # InterPro IPR007874 MinC_N # InterPro IPR013033 MinC # InterPro IPR016098 CAP/MinC_C # KEGG_Brite ko03036 Chromosome # Organism MINC_ECOLI Escherichia coli (strain K12) # PATRIC 32117596 VBIEscCol129921_1220 # PIR A31877 CEECIC # Pfam PF03775 MinC_C # Pfam PF05209 MinC_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MINC_ECOLI Septum site-determining protein MinC # RefSeq NP_415694 NC_000913.3 # RefSeq WP_001301105 NZ_LN832404.1 # SIMILARITY Belongs to the MinC family. {ECO 0000305}. # SUBUNIT MINC_ECOLI Interacts with MinD and FtsZ; homodimer. # SUPFAM SSF63848 SSF63848 # TIGRFAMs TIGR01222 minC # eggNOG COG0850 LUCA # eggNOG ENOG4105K7U Bacteria BLAST swissprot:MINC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MINC_ECOLI BioCyc ECOL316407:JW1165-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1165-MONOMER BioCyc EcoCyc:EG10596-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10596-MONOMER COG COG0850 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0850 DIP DIP-10214N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10214N DOI 10.1016/0092-8674(89)90586-2 http://dx.doi.org/10.1016/0092-8674(89)90586-2 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.96.26.14819 http://dx.doi.org/10.1073/pnas.96.26.14819 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.2012.08021.x http://dx.doi.org/10.1111/j.1365-2958.2012.08021.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.14.3965-3971.2000 http://dx.doi.org/10.1128/JB.182.14.3965-3971.2000 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J03153 http://www.ebi.ac.uk/ena/data/view/J03153 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0591 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0591 EcoGene EG10596 http://www.ecogene.org/geneInfo.php?eg_id=EG10596 EnsemblBacteria AAC74260 http://www.ensemblgenomes.org/id/AAC74260 EnsemblBacteria AAC74260 http://www.ensemblgenomes.org/id/AAC74260 EnsemblBacteria BAA36010 http://www.ensemblgenomes.org/id/BAA36010 EnsemblBacteria BAA36010 http://www.ensemblgenomes.org/id/BAA36010 EnsemblBacteria BAA36010 http://www.ensemblgenomes.org/id/BAA36010 EnsemblBacteria b1176 http://www.ensemblgenomes.org/id/b1176 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0060187 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060187 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0000902 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000902 GO_process GO:0032955 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032955 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GO_process GO:0051302 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051302 GO_process GO:0090529 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090529 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0000902 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000902 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 Gene3D 2.160.20.70 http://www.cathdb.info/version/latest/superfamily/2.160.20.70 GeneID 945744 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945744 HAMAP MF_00267 http://hamap.expasy.org/unirule/MF_00267 HOGENOM HOG000062060 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000062060&db=HOGENOM6 InParanoid P18196 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P18196 IntAct P18196 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P18196* InterPro IPR005526 http://www.ebi.ac.uk/interpro/entry/IPR005526 InterPro IPR007874 http://www.ebi.ac.uk/interpro/entry/IPR007874 InterPro IPR013033 http://www.ebi.ac.uk/interpro/entry/IPR013033 InterPro IPR016098 http://www.ebi.ac.uk/interpro/entry/IPR016098 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene ecj:JW1165 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1165 KEGG_Gene eco:b1176 http://www.genome.jp/dbget-bin/www_bget?eco:b1176 KEGG_Orthology KO:K03610 http://www.genome.jp/dbget-bin/www_bget?KO:K03610 MINT MINT-113907 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-113907 OMA RIYAPNC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RIYAPNC PSORT swissprot:MINC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MINC_ECOLI PSORT-B swissprot:MINC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MINC_ECOLI PSORT2 swissprot:MINC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MINC_ECOLI Pfam PF03775 http://pfam.xfam.org/family/PF03775 Pfam PF05209 http://pfam.xfam.org/family/PF05209 Phobius swissprot:MINC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MINC_ECOLI PhylomeDB P18196 http://phylomedb.org/?seqid=P18196 ProteinModelPortal P18196 http://www.proteinmodelportal.org/query/uniprot/P18196 PubMed 10611296 http://www.ncbi.nlm.nih.gov/pubmed/10611296 PubMed 10869074 http://www.ncbi.nlm.nih.gov/pubmed/10869074 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22380631 http://www.ncbi.nlm.nih.gov/pubmed/22380631 PubMed 2645057 http://www.ncbi.nlm.nih.gov/pubmed/2645057 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415694 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415694 RefSeq WP_001301105 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001301105 SMR P18196 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P18196 STRING 511145.b1176 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1176&targetmode=cogs STRING COG0850 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0850&targetmode=cogs SUPFAM SSF63848 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63848 TIGRFAMs TIGR01222 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01222 UniProtKB MINC_ECOLI http://www.uniprot.org/uniprot/MINC_ECOLI UniProtKB-AC P18196 http://www.uniprot.org/uniprot/P18196 charge swissprot:MINC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MINC_ECOLI eggNOG COG0850 http://eggnogapi.embl.de/nog_data/html/tree/COG0850 eggNOG ENOG4105K7U http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K7U epestfind swissprot:MINC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MINC_ECOLI garnier swissprot:MINC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MINC_ECOLI helixturnhelix swissprot:MINC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MINC_ECOLI hmoment swissprot:MINC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MINC_ECOLI iep swissprot:MINC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MINC_ECOLI inforesidue swissprot:MINC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MINC_ECOLI octanol swissprot:MINC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MINC_ECOLI pepcoil swissprot:MINC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MINC_ECOLI pepdigest swissprot:MINC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MINC_ECOLI pepinfo swissprot:MINC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MINC_ECOLI pepnet swissprot:MINC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MINC_ECOLI pepstats swissprot:MINC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MINC_ECOLI pepwheel swissprot:MINC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MINC_ECOLI pepwindow swissprot:MINC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MINC_ECOLI sigcleave swissprot:MINC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MINC_ECOLI ## Database ID URL or Descriptions # BioGrid 4261743 5 # EcoGene EG14291 ymgC # GO_process GO:0044010 single-species biofilm formation; IMP:EcoCyc. # GOslim_process GO:0008150 biological_process # INDUCTION YMGC_ECOLI Strongly induced at 16 degrees. Expression is repressed by YcgE. At 16 degrees Celsius with blue light irradiation, expression of this operon is absolutely dependent on YcgF for relief of YcgE repression. Part of the ycgZ-ymgA-ariR-ymgC operon. {ECO 0000269|PubMed 18174134, ECO 0000269|PubMed 19240136}. # IntAct P75994 5 # Organism YMGC_ECOLI Escherichia coli (strain K12) # PATRIC 32117569 VBIEscCol129921_1207 # PIR D64862 D64862 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YMGC_ECOLI Uncharacterized protein YmgC # RefSeq NP_415685 NC_000913.3 # RefSeq WP_001065752 NZ_LN832404.1 # eggNOG ENOG410738I Bacteria # eggNOG ENOG410Z8YD LUCA BLAST swissprot:YMGC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YMGC_ECOLI BioCyc ECOL316407:JW1154-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1154-MONOMER BioCyc EcoCyc:G6607-MONOMER http://biocyc.org/getid?id=EcoCyc:G6607-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1099/mic.0.2007/012021-0 http://dx.doi.org/10.1099/mic.0.2007/012021-0 DOI 10.1101/gad.499409 http://dx.doi.org/10.1101/gad.499409 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4039 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4039 EcoGene EG14291 http://www.ecogene.org/geneInfo.php?eg_id=EG14291 EnsemblBacteria AAC74251 http://www.ensemblgenomes.org/id/AAC74251 EnsemblBacteria AAC74251 http://www.ensemblgenomes.org/id/AAC74251 EnsemblBacteria BAA35999 http://www.ensemblgenomes.org/id/BAA35999 EnsemblBacteria BAA35999 http://www.ensemblgenomes.org/id/BAA35999 EnsemblBacteria BAA35999 http://www.ensemblgenomes.org/id/BAA35999 EnsemblBacteria b1167 http://www.ensemblgenomes.org/id/b1167 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0044010 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044010 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 945090 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945090 HOGENOM HOG000009426 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009426&db=HOGENOM6 IntAct P75994 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75994* KEGG_Gene ecj:JW1154 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1154 KEGG_Gene eco:b1167 http://www.genome.jp/dbget-bin/www_bget?eco:b1167 OMA YIIDQAL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YIIDQAL PSORT swissprot:YMGC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YMGC_ECOLI PSORT-B swissprot:YMGC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YMGC_ECOLI PSORT2 swissprot:YMGC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YMGC_ECOLI Phobius swissprot:YMGC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YMGC_ECOLI ProteinModelPortal P75994 http://www.proteinmodelportal.org/query/uniprot/P75994 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18174134 http://www.ncbi.nlm.nih.gov/pubmed/18174134 PubMed 19240136 http://www.ncbi.nlm.nih.gov/pubmed/19240136 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415685 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415685 RefSeq WP_001065752 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001065752 STRING 511145.b1167 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1167&targetmode=cogs UniProtKB YMGC_ECOLI http://www.uniprot.org/uniprot/YMGC_ECOLI UniProtKB-AC P75994 http://www.uniprot.org/uniprot/P75994 charge swissprot:YMGC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YMGC_ECOLI eggNOG ENOG410738I http://eggnogapi.embl.de/nog_data/html/tree/ENOG410738I eggNOG ENOG410Z8YD http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Z8YD epestfind swissprot:YMGC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YMGC_ECOLI garnier swissprot:YMGC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YMGC_ECOLI helixturnhelix swissprot:YMGC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YMGC_ECOLI hmoment swissprot:YMGC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YMGC_ECOLI iep swissprot:YMGC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YMGC_ECOLI inforesidue swissprot:YMGC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YMGC_ECOLI octanol swissprot:YMGC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YMGC_ECOLI pepcoil swissprot:YMGC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YMGC_ECOLI pepdigest swissprot:YMGC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YMGC_ECOLI pepinfo swissprot:YMGC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YMGC_ECOLI pepnet swissprot:YMGC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YMGC_ECOLI pepstats swissprot:YMGC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YMGC_ECOLI pepwheel swissprot:YMGC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YMGC_ECOLI pepwindow swissprot:YMGC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YMGC_ECOLI sigcleave swissprot:YMGC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YMGC_ECOLI ## Database ID URL or Descriptions # AltName Cytidine aminohydrolase {ECO:0000255|HAMAP-Rule MF_01558} # BRENDA 3.5.4 2026 # BioGrid 4263038 9 # CATALYTIC ACTIVITY 2'deoxycytidine + H(2)O = 2'-deoxyuridine + NH(3). {ECO:0000255|HAMAP-Rule MF_01558}. # CATALYTIC ACTIVITY Cytidine + H(2)O = uridine + NH(3). {ECO:0000255|HAMAP-Rule MF_01558}. # COFACTOR CDD_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 8289286, ECO 0000269|PubMed 8634261, ECO 0000269|PubMed 9125497}; Note=Binds 1 zinc ion. {ECO 0000269|PubMed 8289286, ECO 0000269|PubMed 8634261, ECO 0000269|PubMed 9125497}; # DOMAIN CDD_ECOLI Each monomer is composed of a small N-terminal alpha- helical domain and two larger core domains that have nearly identical tertiary structures and are related by approximate two- fold symmetry, but lack homology. # EcoGene EG10137 cdd # FUNCTION CDD_ECOLI This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0001884 pyrimidine nucleoside binding; IDA:EcoliWiki. # GO_function GO:0004126 cytidine deaminase activity; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_function GO:0047844 deoxycytidine deaminase activity; IDA:EcoCyc. # GO_process GO:0006217 deoxycytidine catabolic process; IDA:EcoCyc. # GO_process GO:0009972 cytidine deamination; IMP:EcoCyc. # GO_process GO:0015949 nucleobase-containing small molecule interconversion; IDA:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # GOslim_process GO:0044281 small molecule metabolic process # HAMAP MF_01558 Cyt_deam # INTERACTION CDD_ECOLI Self; NbExp=2; IntAct=EBI-550703, EBI-550703; # IntAct P0ABF6 2 # InterPro IPR002125 CMP_dCMP_Zn-bd # InterPro IPR006263 Cyt_deam_dimer # InterPro IPR013171 Cyd/dCyd_deaminase_Zn-bd # InterPro IPR016192 APOBEC/CMP_deaminase_Zn-bd # InterPro IPR016193 Cytidine_deaminase-like # InterPro IPR020797 Cytidine_deaminase_bacteria # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00240 Pyrimidine metabolism # KEGG_Pathway ko00983 Drug metabolism - other enzymes # Organism CDD_ECOLI Escherichia coli (strain K12) # PATRIC 32119629 VBIEscCol129921_2225 # PDB 1AF2 X-ray; 2.30 A; A=1-294 # PDB 1ALN X-ray; 2.30 A; A=1-294 # PDB 1CTT X-ray; 2.20 A; A=1-294 # PDB 1CTU X-ray; 2.30 A; A=1-294 # PIR F64982 F64982 # PIRSF PIRSF006334 Cdd_plus_pseudo # PROSITE PS00903 CYT_DCMP_DEAMINASES_1 # PROSITE PS51747 CYT_DCMP_DEAMINASES_2; 2 # Pfam PF00383 dCMP_cyt_deam_1 # Pfam PF08211 dCMP_cyt_deam_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Cytidine deaminase {ECO:0000255|HAMAP-Rule MF_01558} # RefSeq NP_416648 NC_000913.3 # RefSeq WP_000553555 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA44849.1; Type=Frameshift; Positions=255; Evidence={ECO 0000305}; # SIMILARITY Belongs to the cytidine and deoxycytidylate deaminase family. {ECO:0000255|HAMAP-Rule MF_01558}. # SIMILARITY Contains 2 CMP/dCMP-type deaminase domains. {ECO:0000255|PROSITE-ProRule PRU01083}. # SUBUNIT CDD_ECOLI Homodimer. {ECO 0000255|HAMAP-Rule MF_01558, ECO 0000269|PubMed 8289286, ECO 0000269|PubMed 8634261, ECO 0000269|PubMed 9125497}. # SUPFAM SSF53927 SSF53927; 2 # TIGRFAMs TIGR01355 cyt_deam_dimer # eggNOG COG0295 LUCA # eggNOG ENOG4107T42 Bacteria BLAST swissprot:CDD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CDD_ECOLI BioCyc ECOL316407:JW2131-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2131-MONOMER BioCyc EcoCyc:CYTIDEAM-MONOMER http://biocyc.org/getid?id=EcoCyc:CYTIDEAM-MONOMER BioCyc MetaCyc:CYTIDEAM-MONOMER http://biocyc.org/getid?id=MetaCyc:CYTIDEAM-MONOMER COG COG0295 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0295 DIP DIP-36169N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36169N DOI 10.1006/jmbi.1994.1018 http://dx.doi.org/10.1006/jmbi.1994.1018 DOI 10.1021/bi00132a003 http://dx.doi.org/10.1021/bi00132a003 DOI 10.1021/bi00450a027 http://dx.doi.org/10.1021/bi00450a027 DOI 10.1021/bi9525583 http://dx.doi.org/10.1021/bi9525583 DOI 10.1021/bi963091e http://dx.doi.org/10.1021/bi963091e DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.90.11.5011 http://dx.doi.org/10.1073/pnas.90.11.5011 DOI 10.1111/j.1365-2958.1989.tb00120.x http://dx.doi.org/10.1111/j.1365-2958.1989.tb00120.x DOI 10.1111/j.1365-2958.1996.tb02652.x http://dx.doi.org/10.1111/j.1365-2958.1996.tb02652.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.5.4.5 {ECO:0000255|HAMAP-Rule:MF_01558} http://www.genome.jp/dbget-bin/www_bget?EC:3.5.4.5 {ECO:0000255|HAMAP-Rule:MF_01558} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M60916 http://www.ebi.ac.uk/ena/data/view/M60916 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X16419 http://www.ebi.ac.uk/ena/data/view/X16419 EMBL X63144 http://www.ebi.ac.uk/ena/data/view/X63144 EMBL Z47804 http://www.ebi.ac.uk/ena/data/view/Z47804 ENZYME 3.5.4.5 {ECO:0000255|HAMAP-Rule:MF_01558} http://enzyme.expasy.org/EC/3.5.4.5 {ECO:0000255|HAMAP-Rule:MF_01558} EchoBASE EB0135 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0135 EcoGene EG10137 http://www.ecogene.org/geneInfo.php?eg_id=EG10137 EnsemblBacteria AAC75204 http://www.ensemblgenomes.org/id/AAC75204 EnsemblBacteria AAC75204 http://www.ensemblgenomes.org/id/AAC75204 EnsemblBacteria BAE76620 http://www.ensemblgenomes.org/id/BAE76620 EnsemblBacteria BAE76620 http://www.ensemblgenomes.org/id/BAE76620 EnsemblBacteria BAE76620 http://www.ensemblgenomes.org/id/BAE76620 EnsemblBacteria b2143 http://www.ensemblgenomes.org/id/b2143 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0001884 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001884 GO_function GO:0004126 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004126 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0047844 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047844 GO_process GO:0006217 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006217 GO_process GO:0009972 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009972 GO_process GO:0015949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015949 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 946663 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946663 HAMAP MF_01558 http://hamap.expasy.org/unirule/MF_01558 HOGENOM HOG000218617 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218617&db=HOGENOM6 InParanoid P0ABF6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABF6 IntAct P0ABF6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABF6* IntEnz 3.5.4.5 {ECO:0000255|HAMAP-Rule:MF_01558} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.4.5 {ECO:0000255|HAMAP-Rule:MF_01558} InterPro IPR002125 http://www.ebi.ac.uk/interpro/entry/IPR002125 InterPro IPR006263 http://www.ebi.ac.uk/interpro/entry/IPR006263 InterPro IPR013171 http://www.ebi.ac.uk/interpro/entry/IPR013171 InterPro IPR016192 http://www.ebi.ac.uk/interpro/entry/IPR016192 InterPro IPR016193 http://www.ebi.ac.uk/interpro/entry/IPR016193 InterPro IPR020797 http://www.ebi.ac.uk/interpro/entry/IPR020797 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2131 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2131 KEGG_Gene eco:b2143 http://www.genome.jp/dbget-bin/www_bget?eco:b2143 KEGG_Orthology KO:K01489 http://www.genome.jp/dbget-bin/www_bget?KO:K01489 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Pathway ko00983 http://www.genome.jp/kegg-bin/show_pathway?ko00983 KEGG_Reaction rn:R01878 http://www.genome.jp/dbget-bin/www_bget?rn:R01878 KEGG_Reaction rn:R02485 http://www.genome.jp/dbget-bin/www_bget?rn:R02485 KEGG_Reaction rn:R08221 http://www.genome.jp/dbget-bin/www_bget?rn:R08221 MINT MINT-1283574 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1283574 OMA NQSHAPY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NQSHAPY PDB 1AF2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1AF2 PDB 1ALN http://www.ebi.ac.uk/pdbe-srv/view/entry/1ALN PDB 1CTT http://www.ebi.ac.uk/pdbe-srv/view/entry/1CTT PDB 1CTU http://www.ebi.ac.uk/pdbe-srv/view/entry/1CTU PDBsum 1AF2 http://www.ebi.ac.uk/pdbsum/1AF2 PDBsum 1ALN http://www.ebi.ac.uk/pdbsum/1ALN PDBsum 1CTT http://www.ebi.ac.uk/pdbsum/1CTT PDBsum 1CTU http://www.ebi.ac.uk/pdbsum/1CTU PROSITE PS00903 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00903 PROSITE PS51747 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51747 PSORT swissprot:CDD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CDD_ECOLI PSORT-B swissprot:CDD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CDD_ECOLI PSORT2 swissprot:CDD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CDD_ECOLI Pfam PF00383 http://pfam.xfam.org/family/PF00383 Pfam PF08211 http://pfam.xfam.org/family/PF08211 Phobius swissprot:CDD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CDD_ECOLI PhylomeDB P0ABF6 http://phylomedb.org/?seqid=P0ABF6 ProteinModelPortal P0ABF6 http://www.proteinmodelportal.org/query/uniprot/P0ABF6 PubMed 1567863 http://www.ncbi.nlm.nih.gov/pubmed/1567863 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2575702 http://www.ncbi.nlm.nih.gov/pubmed/2575702 PubMed 2692708 http://www.ncbi.nlm.nih.gov/pubmed/2692708 PubMed 8289286 http://www.ncbi.nlm.nih.gov/pubmed/8289286 PubMed 8506346 http://www.ncbi.nlm.nih.gov/pubmed/8506346 PubMed 8550448 http://www.ncbi.nlm.nih.gov/pubmed/8550448 PubMed 8634261 http://www.ncbi.nlm.nih.gov/pubmed/8634261 PubMed 8899705 http://www.ncbi.nlm.nih.gov/pubmed/8899705 PubMed 9125497 http://www.ncbi.nlm.nih.gov/pubmed/9125497 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416648 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416648 RefSeq WP_000553555 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000553555 SMR P0ABF6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABF6 STRING 511145.b2143 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2143&targetmode=cogs STRING COG0295 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0295&targetmode=cogs SUPFAM SSF53927 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53927 SWISS-2DPAGE P0ABF6 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0ABF6 TIGRFAMs TIGR01355 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01355 UniProtKB CDD_ECOLI http://www.uniprot.org/uniprot/CDD_ECOLI UniProtKB-AC P0ABF6 http://www.uniprot.org/uniprot/P0ABF6 charge swissprot:CDD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CDD_ECOLI eggNOG COG0295 http://eggnogapi.embl.de/nog_data/html/tree/COG0295 eggNOG ENOG4107T42 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107T42 epestfind swissprot:CDD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CDD_ECOLI garnier swissprot:CDD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CDD_ECOLI helixturnhelix swissprot:CDD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CDD_ECOLI hmoment swissprot:CDD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CDD_ECOLI iep swissprot:CDD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CDD_ECOLI inforesidue swissprot:CDD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CDD_ECOLI octanol swissprot:CDD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CDD_ECOLI pepcoil swissprot:CDD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CDD_ECOLI pepdigest swissprot:CDD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CDD_ECOLI pepinfo swissprot:CDD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CDD_ECOLI pepnet swissprot:CDD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CDD_ECOLI pepstats swissprot:CDD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CDD_ECOLI pepwheel swissprot:CDD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CDD_ECOLI pepwindow swissprot:CDD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CDD_ECOLI sigcleave swissprot:CDD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CDD_ECOLI ## Database ID URL or Descriptions # BioGrid 4261412 969 # EcoGene EG10271 exbB # FUNCTION EXBB_ECOLI Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates. Protects ExbD from proteolytic degradation and functionally stabilizes TonB. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0008565 protein transporter activity; IEA:InterPro. # GO_function GO:0022891 substrate-specific transmembrane transporter activity; IBA:GO_Central. # GO_function GO:0031992 energy transducer activity; IMP:EcoCyc. # GO_process GO:0043213 bacteriocin transport; IEA:UniProtKB-KW. # GO_process GO:0050821 protein stabilization; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008565 protein transporter activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # INDUCTION Induced 2.4-fold by hydroxyurea. {ECO:0000269|PubMed 20005847}. # INTERACTION EXBB_ECOLI P0ABV2 exbD; NbExp=2; IntAct=EBI-6399986, EBI-6417016; P02929 tonB; NbExp=2; IntAct=EBI-6399986, EBI-6399993; # IntAct P0ABU7 3 # InterPro IPR002898 MotA_ExbB_proton_chnl # InterPro IPR014164 TonB_ExbB_1 # KEGG_Brite ko02000 Transporters # Organism EXBB_ECOLI Escherichia coli (strain K12) # PATRIC 32121428 VBIEscCol129921_3101 # PDB 5SV0 X-ray; 2.60 A; A/B/C/D/E/F/G/H/I/J=1-244 # PDB 5SV1 X-ray; 3.50 A; A/B/C/D/E/F/G/H/I/J=1-244 # PIR D65087 BVECXB # Pfam PF01618 MotA_ExbB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EXBB_ECOLI Biopolymer transport protein ExbB # RefSeq NP_417479 NC_000913.3 # RefSeq WP_000527844 NZ_LN832404.1 # SIMILARITY Belongs to the ExbB/TolQ family. {ECO 0000305}. # SUBCELLULAR LOCATION EXBB_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT EXBB_ECOLI The accessory proteins ExbB and ExbD seem to form a complex with TonB. # TCDB 1.A.30.2 the h(+)- or na(+)-translocating bacterial flagellar motor/exbbd outer membrane transport energizer (mot/exb) superfamily # TIGRFAMs TIGR02797 exbB # eggNOG COG0811 LUCA # eggNOG ENOG4105CWK Bacteria BLAST swissprot:EXBB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EXBB_ECOLI BioCyc ECOL316407:JW2974-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2974-MONOMER BioCyc EcoCyc:EG10271-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10271-MONOMER BioCyc MetaCyc:EG10271-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10271-MONOMER COG COG0811 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0811 DIP DIP-47841N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47841N DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M28819 http://www.ebi.ac.uk/ena/data/view/M28819 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB0267 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0267 EcoGene EG10271 http://www.ecogene.org/geneInfo.php?eg_id=EG10271 EnsemblBacteria AAC76042 http://www.ensemblgenomes.org/id/AAC76042 EnsemblBacteria AAC76042 http://www.ensemblgenomes.org/id/AAC76042 EnsemblBacteria BAE77064 http://www.ensemblgenomes.org/id/BAE77064 EnsemblBacteria BAE77064 http://www.ensemblgenomes.org/id/BAE77064 EnsemblBacteria BAE77064 http://www.ensemblgenomes.org/id/BAE77064 EnsemblBacteria b3006 http://www.ensemblgenomes.org/id/b3006 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GO_function GO:0022891 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022891 GO_function GO:0031992 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031992 GO_process GO:0043213 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043213 GO_process GO:0050821 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050821 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 945420 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945420 HOGENOM HOG000134793 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000134793&db=HOGENOM6 InParanoid P0ABU7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABU7 IntAct P0ABU7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABU7* InterPro IPR002898 http://www.ebi.ac.uk/interpro/entry/IPR002898 InterPro IPR014164 http://www.ebi.ac.uk/interpro/entry/IPR014164 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2974 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2974 KEGG_Gene eco:b3006 http://www.genome.jp/dbget-bin/www_bget?eco:b3006 KEGG_Orthology KO:K03561 http://www.genome.jp/dbget-bin/www_bget?KO:K03561 OMA MAHDLSP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MAHDLSP PDB 5SV0 http://www.ebi.ac.uk/pdbe-srv/view/entry/5SV0 PDB 5SV1 http://www.ebi.ac.uk/pdbe-srv/view/entry/5SV1 PDBsum 5SV0 http://www.ebi.ac.uk/pdbsum/5SV0 PDBsum 5SV1 http://www.ebi.ac.uk/pdbsum/5SV1 PSORT swissprot:EXBB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EXBB_ECOLI PSORT-B swissprot:EXBB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EXBB_ECOLI PSORT2 swissprot:EXBB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EXBB_ECOLI Pfam PF01618 http://pfam.xfam.org/family/PF01618 Phobius swissprot:EXBB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EXBB_ECOLI PhylomeDB P0ABU7 http://phylomedb.org/?seqid=P0ABU7 ProteinModelPortal P0ABU7 http://www.proteinmodelportal.org/query/uniprot/P0ABU7 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 2670903 http://www.ncbi.nlm.nih.gov/pubmed/2670903 PubMed 8449962 http://www.ncbi.nlm.nih.gov/pubmed/8449962 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417479 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417479 RefSeq WP_000527844 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000527844 STRING 511145.b3006 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3006&targetmode=cogs STRING COG0811 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0811&targetmode=cogs TCDB 1.A.30.2 http://www.tcdb.org/search/result.php?tc=1.A.30.2 TIGRFAMs TIGR02797 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02797 UniProtKB EXBB_ECOLI http://www.uniprot.org/uniprot/EXBB_ECOLI UniProtKB-AC P0ABU7 http://www.uniprot.org/uniprot/P0ABU7 charge swissprot:EXBB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EXBB_ECOLI eggNOG COG0811 http://eggnogapi.embl.de/nog_data/html/tree/COG0811 eggNOG ENOG4105CWK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CWK epestfind swissprot:EXBB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EXBB_ECOLI garnier swissprot:EXBB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EXBB_ECOLI helixturnhelix swissprot:EXBB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EXBB_ECOLI hmoment swissprot:EXBB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EXBB_ECOLI iep swissprot:EXBB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EXBB_ECOLI inforesidue swissprot:EXBB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EXBB_ECOLI octanol swissprot:EXBB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EXBB_ECOLI pepcoil swissprot:EXBB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EXBB_ECOLI pepdigest swissprot:EXBB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EXBB_ECOLI pepinfo swissprot:EXBB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EXBB_ECOLI pepnet swissprot:EXBB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EXBB_ECOLI pepstats swissprot:EXBB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EXBB_ECOLI pepwheel swissprot:EXBB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EXBB_ECOLI pepwindow swissprot:EXBB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EXBB_ECOLI sigcleave swissprot:EXBB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EXBB_ECOLI ## Database ID URL or Descriptions # BioGrid 4262378 169 # DISRUPTION PHENOTYPE YGHB_ECOLI Double mutants lacking both yghB and yqjA show incomplete cell division, temperature sensitivity and altered phospholipid levels. They are also hypersensitive to several compounds known to be exported by other drug efflux proteins, including ethidium bromide, methyl viologen, acriflavine and beta- lactam antibiotics. Expression of either yghB or yqjA can restore the wild-type phenotype, suggesting that these proteins have redundant functions. Both individual null mutant strains grow normally at all temperatures. {ECO 0000269|PubMed 18456815, ECO 0000269|PubMed 19880597, ECO 0000269|PubMed 24277026}. # EcoGene EG11824 yghB # FUNCTION YGHB_ECOLI May be a membrane transporter required for proton motive force (PMF)-dependent drug efflux. Required, with YqjA, for the proper export of certain periplasmic amidases and, possibly, other Tat substrates. May play a role in determining membrane lipid composition. {ECO 0000269|PubMed 18456815, ECO 0000269|PubMed 19880597, ECO 0000269|PubMed 24277026}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_function GO:0022857 transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0043093 FtsZ-dependent cytokinesis; IGI:EcoCyc. # GO_process GO:0055085 transmembrane transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0055085 transmembrane transport # InterPro IPR032816 SNARE_assoc # InterPro IPR032818 DedA # Organism YGHB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30353 PTHR30353 # PATRIC 32121432 VBIEscCol129921_3103 # PIR G65087 G65087 # Pfam PF09335 SNARE_assoc # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGHB_ECOLI Inner membrane protein YghB # RefSeq NP_417482 NC_000913.3 # RefSeq WP_000268419 NZ_LN832404.1 # SIMILARITY Belongs to the DedA family. {ECO 0000305}. # SUBCELLULAR LOCATION YGHB_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 9.B.27.2 the deda or ydjx-z (deda) family # eggNOG COG0586 LUCA # eggNOG ENOG4108K81 Bacteria BLAST swissprot:YGHB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGHB_ECOLI BioCyc ECOL316407:JW2976-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2976-MONOMER BioCyc EcoCyc:EG11824-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11824-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.83.4.867 http://dx.doi.org/10.1073/pnas.83.4.867 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AAC.02238-13 http://dx.doi.org/10.1128/AAC.02238-13 DOI 10.1128/JB.00414-08 http://dx.doi.org/10.1128/JB.00414-08 DOI 10.1128/JB.00716-09 http://dx.doi.org/10.1128/JB.00716-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M12858 http://www.ebi.ac.uk/ena/data/view/M12858 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB1771 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1771 EcoGene EG11824 http://www.ecogene.org/geneInfo.php?eg_id=EG11824 EnsemblBacteria AAC76045 http://www.ensemblgenomes.org/id/AAC76045 EnsemblBacteria AAC76045 http://www.ensemblgenomes.org/id/AAC76045 EnsemblBacteria BAE77066 http://www.ensemblgenomes.org/id/BAE77066 EnsemblBacteria BAE77066 http://www.ensemblgenomes.org/id/BAE77066 EnsemblBacteria BAE77066 http://www.ensemblgenomes.org/id/BAE77066 EnsemblBacteria b3009 http://www.ensemblgenomes.org/id/b3009 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GO_process GO:0043093 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043093 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 947490 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947490 HOGENOM HOG000105367 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000105367&db=HOGENOM6 InParanoid P0AA60 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AA60 InterPro IPR032816 http://www.ebi.ac.uk/interpro/entry/IPR032816 InterPro IPR032818 http://www.ebi.ac.uk/interpro/entry/IPR032818 KEGG_Gene ecj:JW2976 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2976 KEGG_Gene eco:b3009 http://www.genome.jp/dbget-bin/www_bget?eco:b3009 OMA ASLLMYW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ASLLMYW PANTHER PTHR30353 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30353 PSORT swissprot:YGHB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGHB_ECOLI PSORT-B swissprot:YGHB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGHB_ECOLI PSORT2 swissprot:YGHB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGHB_ECOLI Pfam PF09335 http://pfam.xfam.org/family/PF09335 Phobius swissprot:YGHB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGHB_ECOLI PhylomeDB P0AA60 http://phylomedb.org/?seqid=P0AA60 ProteinModelPortal P0AA60 http://www.proteinmodelportal.org/query/uniprot/P0AA60 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18456815 http://www.ncbi.nlm.nih.gov/pubmed/18456815 PubMed 19880597 http://www.ncbi.nlm.nih.gov/pubmed/19880597 PubMed 24277026 http://www.ncbi.nlm.nih.gov/pubmed/24277026 PubMed 3513164 http://www.ncbi.nlm.nih.gov/pubmed/3513164 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417482 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417482 RefSeq WP_000268419 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000268419 STRING 511145.b3009 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3009&targetmode=cogs TCDB 9.B.27.2 http://www.tcdb.org/search/result.php?tc=9.B.27.2 UniProtKB YGHB_ECOLI http://www.uniprot.org/uniprot/YGHB_ECOLI UniProtKB-AC P0AA60 http://www.uniprot.org/uniprot/P0AA60 charge swissprot:YGHB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGHB_ECOLI eggNOG COG0586 http://eggnogapi.embl.de/nog_data/html/tree/COG0586 eggNOG ENOG4108K81 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108K81 epestfind swissprot:YGHB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGHB_ECOLI garnier swissprot:YGHB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGHB_ECOLI helixturnhelix swissprot:YGHB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGHB_ECOLI hmoment swissprot:YGHB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGHB_ECOLI iep swissprot:YGHB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGHB_ECOLI inforesidue swissprot:YGHB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGHB_ECOLI octanol swissprot:YGHB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGHB_ECOLI pepcoil swissprot:YGHB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGHB_ECOLI pepdigest swissprot:YGHB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGHB_ECOLI pepinfo swissprot:YGHB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGHB_ECOLI pepnet swissprot:YGHB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGHB_ECOLI pepstats swissprot:YGHB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGHB_ECOLI pepwheel swissprot:YGHB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGHB_ECOLI pepwindow swissprot:YGHB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGHB_ECOLI sigcleave swissprot:YGHB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGHB_ECOLI ## Database ID URL or Descriptions # AltName FRVR_ECOLI Putative PTS system EIIA component # BioGrid 4263326 6 # DOMAIN FRVR_ECOLI The PTS EIIA type-2 domain may serve a regulatory function, through its phosphorylation activity. # EcoGene EG11861 frvR # FUNCTION FRVR_ECOLI Could be involved in the regulation of the transcription of the FRV operon. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0005215 transporter activity; IEA:InterPro. # GO_function GO:0016301 kinase activity; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; ISS:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016301 kinase activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # Gene3D 3.40.930.10 -; 1. # InterPro IPR002178 PTS_EIIA_type-2_dom # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR013196 HTH_11 # InterPro IPR016152 PTrfase/Anion_transptr # Organism FRVR_ECOLI Escherichia coli (strain K12) # PATRIC 32123303 VBIEscCol129921_4012 # PIR S40841 S40841 # PROSITE PS51094 PTS_EIIA_TYPE_2 # Pfam PF00359 PTS_EIIA_2 # Pfam PF08279 HTH_11 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FRVR_ECOLI Putative frv operon regulatory protein # RecName FRVR_ECOLI Putative frv operon regulatory protein # RecName FRVR_ECOLI Putative phosphotransferase EIIA component # RefSeq NP_418333 NC_000913.3 # RefSeq WP_000931299 NZ_LN832404.1 # SIMILARITY Contains 1 PTS EIIA type-2 domain. {ECO:0000255|PROSITE-ProRule PRU00417}. # SUPFAM SSF46785 SSF46785 # SUPFAM SSF55804 SSF55804 # eggNOG COG1762 LUCA # eggNOG COG3711 LUCA # eggNOG ENOG4106C3V Bacteria BLAST swissprot:FRVR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FRVR_ECOLI BioCyc ECOL316407:JW3868-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3868-MONOMER BioCyc EcoCyc:EG11861-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11861-MONOMER DOI 10.1002/pro.5560030309 http://dx.doi.org/10.1002/pro.5560030309 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.- http://enzyme.expasy.org/EC/2.7.1.- EchoBASE EB1807 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1807 EcoGene EG11861 http://www.ecogene.org/geneInfo.php?eg_id=EG11861 EnsemblBacteria AAC76879 http://www.ensemblgenomes.org/id/AAC76879 EnsemblBacteria AAC76879 http://www.ensemblgenomes.org/id/AAC76879 EnsemblBacteria BAE77412 http://www.ensemblgenomes.org/id/BAE77412 EnsemblBacteria BAE77412 http://www.ensemblgenomes.org/id/BAE77412 EnsemblBacteria BAE77412 http://www.ensemblgenomes.org/id/BAE77412 EnsemblBacteria b3897 http://www.ensemblgenomes.org/id/b3897 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 3.40.930.10 http://www.cathdb.info/version/latest/superfamily/3.40.930.10 GeneID 948389 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948389 HOGENOM HOG000009657 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009657&db=HOGENOM6 InParanoid P32152 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32152 IntAct P32152 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32152* IntEnz 2.7.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1 InterPro IPR002178 http://www.ebi.ac.uk/interpro/entry/IPR002178 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR013196 http://www.ebi.ac.uk/interpro/entry/IPR013196 InterPro IPR016152 http://www.ebi.ac.uk/interpro/entry/IPR016152 KEGG_Gene ecj:JW3868 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3868 KEGG_Gene eco:b3897 http://www.genome.jp/dbget-bin/www_bget?eco:b3897 OMA EIINHVL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EIINHVL PROSITE PS51094 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51094 PSORT swissprot:FRVR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FRVR_ECOLI PSORT-B swissprot:FRVR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FRVR_ECOLI PSORT2 swissprot:FRVR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FRVR_ECOLI Pfam PF00359 http://pfam.xfam.org/family/PF00359 Pfam PF08279 http://pfam.xfam.org/family/PF08279 Phobius swissprot:FRVR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FRVR_ECOLI PhylomeDB P32152 http://phylomedb.org/?seqid=P32152 ProteinModelPortal P32152 http://www.proteinmodelportal.org/query/uniprot/P32152 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8019415 http://www.ncbi.nlm.nih.gov/pubmed/8019415 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418333 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418333 RefSeq WP_000931299 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000931299 SMR P32152 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32152 STRING 511145.b3897 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3897&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SUPFAM SSF55804 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55804 UniProtKB FRVR_ECOLI http://www.uniprot.org/uniprot/FRVR_ECOLI UniProtKB-AC P32152 http://www.uniprot.org/uniprot/P32152 charge swissprot:FRVR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FRVR_ECOLI eggNOG COG1762 http://eggnogapi.embl.de/nog_data/html/tree/COG1762 eggNOG COG3711 http://eggnogapi.embl.de/nog_data/html/tree/COG3711 eggNOG ENOG4106C3V http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106C3V epestfind swissprot:FRVR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FRVR_ECOLI garnier swissprot:FRVR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FRVR_ECOLI helixturnhelix swissprot:FRVR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FRVR_ECOLI hmoment swissprot:FRVR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FRVR_ECOLI iep swissprot:FRVR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FRVR_ECOLI inforesidue swissprot:FRVR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FRVR_ECOLI octanol swissprot:FRVR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FRVR_ECOLI pepcoil swissprot:FRVR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FRVR_ECOLI pepdigest swissprot:FRVR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FRVR_ECOLI pepinfo swissprot:FRVR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FRVR_ECOLI pepnet swissprot:FRVR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FRVR_ECOLI pepstats swissprot:FRVR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FRVR_ECOLI pepwheel swissprot:FRVR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FRVR_ECOLI pepwindow swissprot:FRVR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FRVR_ECOLI sigcleave swissprot:FRVR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FRVR_ECOLI ## Database ID URL or Descriptions # BioGrid 4260754 13 # EcoGene EG14166 yfeY # InterPro IPR010938 DUF1131 # Organism YFEY_ECOLI Escherichia coli (strain K12) # PATRIC 32120249 VBIEscCol129921_2527 # PDB 2QZB X-ray; 2.10 A; A/B=28-191 # PIR G65017 G65017 # Pfam PF06572 DUF1131 # ProDom PD105195 DUF1131 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFEY_ECOLI Uncharacterized protein YfeY # RefSeq NP_416927 NC_000913.3 # RefSeq WP_000838944 NZ_LN832404.1 # eggNOG ENOG4105E7K Bacteria # eggNOG ENOG410XXK0 LUCA BLAST swissprot:YFEY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFEY_ECOLI BioCyc ECOL316407:JW2425-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2425-MONOMER BioCyc EcoCyc:G7267-MONOMER http://biocyc.org/getid?id=EcoCyc:G7267-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1271/bbb.58.117 http://dx.doi.org/10.1271/bbb.58.117 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D21150 http://www.ebi.ac.uk/ena/data/view/D21150 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3918 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3918 EcoGene EG14166 http://www.ecogene.org/geneInfo.php?eg_id=EG14166 EnsemblBacteria AAC75485 http://www.ensemblgenomes.org/id/AAC75485 EnsemblBacteria AAC75485 http://www.ensemblgenomes.org/id/AAC75485 EnsemblBacteria BAE76712 http://www.ensemblgenomes.org/id/BAE76712 EnsemblBacteria BAE76712 http://www.ensemblgenomes.org/id/BAE76712 EnsemblBacteria BAE76712 http://www.ensemblgenomes.org/id/BAE76712 EnsemblBacteria b2432 http://www.ensemblgenomes.org/id/b2432 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946919 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946919 HOGENOM HOG000123007 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000123007&db=HOGENOM6 InterPro IPR010938 http://www.ebi.ac.uk/interpro/entry/IPR010938 KEGG_Gene ecj:JW2425 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2425 KEGG_Gene eco:b2432 http://www.genome.jp/dbget-bin/www_bget?eco:b2432 OMA NWFGSSL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NWFGSSL PDB 2QZB http://www.ebi.ac.uk/pdbe-srv/view/entry/2QZB PDBsum 2QZB http://www.ebi.ac.uk/pdbsum/2QZB PSORT swissprot:YFEY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFEY_ECOLI PSORT-B swissprot:YFEY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFEY_ECOLI PSORT2 swissprot:YFEY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFEY_ECOLI Pfam PF06572 http://pfam.xfam.org/family/PF06572 Phobius swissprot:YFEY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFEY_ECOLI ProteinModelPortal P76537 http://www.proteinmodelportal.org/query/uniprot/P76537 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7764507 http://www.ncbi.nlm.nih.gov/pubmed/7764507 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416927 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416927 RefSeq WP_000838944 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000838944 SMR P76537 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76537 STRING 511145.b2432 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2432&targetmode=cogs UniProtKB YFEY_ECOLI http://www.uniprot.org/uniprot/YFEY_ECOLI UniProtKB-AC P76537 http://www.uniprot.org/uniprot/P76537 charge swissprot:YFEY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFEY_ECOLI eggNOG ENOG4105E7K http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E7K eggNOG ENOG410XXK0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XXK0 epestfind swissprot:YFEY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFEY_ECOLI garnier swissprot:YFEY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFEY_ECOLI helixturnhelix swissprot:YFEY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFEY_ECOLI hmoment swissprot:YFEY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFEY_ECOLI iep swissprot:YFEY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFEY_ECOLI inforesidue swissprot:YFEY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFEY_ECOLI octanol swissprot:YFEY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFEY_ECOLI pepcoil swissprot:YFEY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFEY_ECOLI pepdigest swissprot:YFEY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFEY_ECOLI pepinfo swissprot:YFEY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFEY_ECOLI pepnet swissprot:YFEY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFEY_ECOLI pepstats swissprot:YFEY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFEY_ECOLI pepwheel swissprot:YFEY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFEY_ECOLI pepwindow swissprot:YFEY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFEY_ECOLI sigcleave swissprot:YFEY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFEY_ECOLI ## Database ID URL or Descriptions # BioGrid 4261573 58 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG14137 yfdO # GO_process GO:0006979 response to oxidative stress; IMP:EcoCyc. # GOslim_process GO:0006950 response to stress # IntAct P0AD35 2 # Organism YFDO_ECOLI Escherichia coli (strain K12) # PATRIC 48664118 VBIEscCol107702_2399 # PIR C65009 C65009 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFDO_ECOLI Putative uncharacterized protein YfdO # SIMILARITY Belongs to the phage O protein family. {ECO 0000305}. BLAST swissprot:YFDO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFDO_ECOLI BioCyc ECOL316407:JW2355-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2355-MONOMER BioCyc EcoCyc:G7227-MONOMER http://biocyc.org/getid?id=EcoCyc:G7227-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3889 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3889 EcoGene EG14137 http://www.ecogene.org/geneInfo.php?eg_id=EG14137 EnsemblBacteria BAA16223 http://www.ensemblgenomes.org/id/BAA16223 EnsemblBacteria BAA16223 http://www.ensemblgenomes.org/id/BAA16223 EnsemblBacteria BAA16223 http://www.ensemblgenomes.org/id/BAA16223 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 HOGENOM HOG000123869 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000123869&db=HOGENOM6 IntAct P0AD35 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AD35* KEGG_Gene ecj:JW2355 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2355 OMA KNIMSPX http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KNIMSPX PSORT swissprot:YFDO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFDO_ECOLI PSORT-B swissprot:YFDO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFDO_ECOLI PSORT2 swissprot:YFDO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFDO_ECOLI Phobius swissprot:YFDO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFDO_ECOLI ProteinModelPortal P0AD35 http://www.proteinmodelportal.org/query/uniprot/P0AD35 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SMR P0AD35 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AD35 STRING 316407.85675372 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85675372&targetmode=cogs UniProtKB YFDO_ECOLI http://www.uniprot.org/uniprot/YFDO_ECOLI UniProtKB-AC P0AD35 http://www.uniprot.org/uniprot/P0AD35 charge swissprot:YFDO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFDO_ECOLI epestfind swissprot:YFDO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFDO_ECOLI garnier swissprot:YFDO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFDO_ECOLI helixturnhelix swissprot:YFDO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFDO_ECOLI hmoment swissprot:YFDO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFDO_ECOLI iep swissprot:YFDO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFDO_ECOLI inforesidue swissprot:YFDO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFDO_ECOLI octanol swissprot:YFDO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFDO_ECOLI pepcoil swissprot:YFDO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFDO_ECOLI pepdigest swissprot:YFDO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFDO_ECOLI pepinfo swissprot:YFDO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFDO_ECOLI pepnet swissprot:YFDO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFDO_ECOLI pepstats swissprot:YFDO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFDO_ECOLI pepwheel swissprot:YFDO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFDO_ECOLI pepwindow swissprot:YFDO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFDO_ECOLI sigcleave swissprot:YFDO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFDO_ECOLI ## Database ID URL or Descriptions # AltName MTLR_ECOLI Mannitol repressor protein # BioGrid 4263545 10 # EcoGene EG11965 mtlR # FUNCTION MTLR_ECOLI Acts as a repressor of the mtlAD operon. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IMP:EcoCyc. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # IntAct P0AF10 11 # InterPro IPR007761 MtlR # KEGG_Brite ko03000 Transcription factors # Organism MTLR_ECOLI Escherichia coli (strain K12) # PATRIC 32122685 VBIEscCol129921_3719 # PIR B36970 B36970 # Pfam PF05068 MtlR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MTLR_ECOLI Mannitol operon repressor # RefSeq NP_418058 NC_000913.3 # SIMILARITY To E.coli YggD. {ECO 0000305}. # eggNOG COG3722 LUCA # eggNOG ENOG4105E61 Bacteria BLAST swissprot:MTLR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MTLR_ECOLI BioCyc ECOL316407:JW3575-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3575-MONOMER BioCyc EcoCyc:PD00369 http://biocyc.org/getid?id=EcoCyc:PD00369 COG COG3722 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3722 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1111/j.1365-2958.1990.tb02050.x http://dx.doi.org/10.1111/j.1365-2958.1990.tb02050.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U03845 http://www.ebi.ac.uk/ena/data/view/U03845 EMBL X51359 http://www.ebi.ac.uk/ena/data/view/X51359 EchoBASE EB1908 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1908 EcoGene EG11965 http://www.ecogene.org/geneInfo.php?eg_id=EG11965 EnsemblBacteria AAC76625 http://www.ensemblgenomes.org/id/AAC76625 EnsemblBacteria AAC76625 http://www.ensemblgenomes.org/id/AAC76625 EnsemblBacteria BAE77692 http://www.ensemblgenomes.org/id/BAE77692 EnsemblBacteria BAE77692 http://www.ensemblgenomes.org/id/BAE77692 EnsemblBacteria BAE77692 http://www.ensemblgenomes.org/id/BAE77692 EnsemblBacteria b3601 http://www.ensemblgenomes.org/id/b3601 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 948116 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948116 HOGENOM HOG000271380 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000271380&db=HOGENOM6 IntAct P0AF10 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AF10* InterPro IPR007761 http://www.ebi.ac.uk/interpro/entry/IPR007761 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW3575 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3575 KEGG_Gene eco:b3601 http://www.genome.jp/dbget-bin/www_bget?eco:b3601 KEGG_Orthology KO:K02562 http://www.genome.jp/dbget-bin/www_bget?KO:K02562 OMA NFAVQSV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NFAVQSV PSORT swissprot:MTLR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MTLR_ECOLI PSORT-B swissprot:MTLR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MTLR_ECOLI PSORT2 swissprot:MTLR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MTLR_ECOLI Pfam PF05068 http://pfam.xfam.org/family/PF05068 Phobius swissprot:MTLR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MTLR_ECOLI ProteinModelPortal P0AF10 http://www.proteinmodelportal.org/query/uniprot/P0AF10 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1964486 http://www.ncbi.nlm.nih.gov/pubmed/1964486 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 8300537 http://www.ncbi.nlm.nih.gov/pubmed/8300537 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418058 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418058 SMR P0AF10 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AF10 STRING 511145.b3601 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3601&targetmode=cogs STRING COG3722 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3722&targetmode=cogs UniProtKB MTLR_ECOLI http://www.uniprot.org/uniprot/MTLR_ECOLI UniProtKB-AC P0AF10 http://www.uniprot.org/uniprot/P0AF10 charge swissprot:MTLR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MTLR_ECOLI eggNOG COG3722 http://eggnogapi.embl.de/nog_data/html/tree/COG3722 eggNOG ENOG4105E61 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E61 epestfind swissprot:MTLR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MTLR_ECOLI garnier swissprot:MTLR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MTLR_ECOLI helixturnhelix swissprot:MTLR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MTLR_ECOLI hmoment swissprot:MTLR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MTLR_ECOLI iep swissprot:MTLR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MTLR_ECOLI inforesidue swissprot:MTLR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MTLR_ECOLI octanol swissprot:MTLR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MTLR_ECOLI pepcoil swissprot:MTLR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MTLR_ECOLI pepdigest swissprot:MTLR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MTLR_ECOLI pepinfo swissprot:MTLR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MTLR_ECOLI pepnet swissprot:MTLR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MTLR_ECOLI pepstats swissprot:MTLR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MTLR_ECOLI pepwheel swissprot:MTLR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MTLR_ECOLI pepwindow swissprot:MTLR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MTLR_ECOLI sigcleave swissprot:MTLR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MTLR_ECOLI ## Database ID URL or Descriptions # BioGrid 4261836 11 # EcoGene EG13314 ybhF # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016887 ATPase activity; IEA:InterPro. # GO_process GO:0006810 transport; IEA:UniProtKB-KW. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # Gene3D 3.40.50.300 -; 2. # INTERACTION YBHF_ECOLI P0AFG8 aceE; NbExp=2; IntAct=EBI-547696, EBI-542683; P60566 fixA; NbExp=3; IntAct=EBI-547696, EBI-1113126; # IntAct P0A9U1 7 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00254 ABC-2 type transport system # KEGG_Brite ko02000 Transporters # Organism YBHF_ECOLI Escherichia coli (strain K12) # PATRIC 32116789 VBIEscCol129921_0820 # PIR B64816 B64816 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2; 2 # Pfam PF00005 ABC_tran; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBHF_ECOLI Uncharacterized ABC transporter ATP-binding protein YbhF # RefSeq NP_415315 NC_000913.3 # RefSeq WP_000996107 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. {ECO 0000305}. # SIMILARITY Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA; 2 # SUPFAM SSF52540 SSF52540; 2 # TCDB 3.A.1.105.15 the atp-binding cassette (abc) superfamily # eggNOG COG1131 LUCA # eggNOG ENOG4105CJ1 Bacteria BLAST swissprot:YBHF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBHF_ECOLI BioCyc ECOL316407:JW5104-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5104-MONOMER BioCyc EcoCyc:YBHF-MONOMER http://biocyc.org/getid?id=EcoCyc:YBHF-MONOMER COG COG1131 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1131 COG COG1134 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1134 DIP DIP-48149N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48149N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3098 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3098 EcoGene EG13314 http://www.ecogene.org/geneInfo.php?eg_id=EG13314 EnsemblBacteria AAC73881 http://www.ensemblgenomes.org/id/AAC73881 EnsemblBacteria AAC73881 http://www.ensemblgenomes.org/id/AAC73881 EnsemblBacteria BAA35454 http://www.ensemblgenomes.org/id/BAA35454 EnsemblBacteria BAA35454 http://www.ensemblgenomes.org/id/BAA35454 EnsemblBacteria BAA35454 http://www.ensemblgenomes.org/id/BAA35454 EnsemblBacteria b0794 http://www.ensemblgenomes.org/id/b0794 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945413 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945413 HOGENOM HOG000014887 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000014887&db=HOGENOM6 InParanoid P0A9U1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9U1 IntAct P0A9U1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9U1* InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5104 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5104 KEGG_Gene eco:b0794 http://www.genome.jp/dbget-bin/www_bget?eco:b0794 KEGG_Orthology KO:K01990 http://www.genome.jp/dbget-bin/www_bget?KO:K01990 MINT MINT-1249856 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1249856 OMA GLVYHGK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GLVYHGK PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:YBHF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBHF_ECOLI PSORT-B swissprot:YBHF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBHF_ECOLI PSORT2 swissprot:YBHF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBHF_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Phobius swissprot:YBHF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBHF_ECOLI PhylomeDB P0A9U1 http://phylomedb.org/?seqid=P0A9U1 ProteinModelPortal P0A9U1 http://www.proteinmodelportal.org/query/uniprot/P0A9U1 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415315 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415315 RefSeq WP_000996107 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000996107 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P0A9U1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9U1 STRING 511145.b0794 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0794&targetmode=cogs STRING COG1131 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1131&targetmode=cogs STRING COG1134 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1134&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.105.15 http://www.tcdb.org/search/result.php?tc=3.A.1.105.15 UniProtKB YBHF_ECOLI http://www.uniprot.org/uniprot/YBHF_ECOLI UniProtKB-AC P0A9U1 http://www.uniprot.org/uniprot/P0A9U1 charge swissprot:YBHF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBHF_ECOLI eggNOG COG1131 http://eggnogapi.embl.de/nog_data/html/tree/COG1131 eggNOG ENOG4105CJ1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CJ1 epestfind swissprot:YBHF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBHF_ECOLI garnier swissprot:YBHF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBHF_ECOLI helixturnhelix swissprot:YBHF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBHF_ECOLI hmoment swissprot:YBHF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBHF_ECOLI iep swissprot:YBHF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBHF_ECOLI inforesidue swissprot:YBHF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBHF_ECOLI octanol swissprot:YBHF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBHF_ECOLI pepcoil swissprot:YBHF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBHF_ECOLI pepdigest swissprot:YBHF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBHF_ECOLI pepinfo swissprot:YBHF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBHF_ECOLI pepnet swissprot:YBHF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBHF_ECOLI pepstats swissprot:YBHF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBHF_ECOLI pepwheel swissprot:YBHF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBHF_ECOLI pepwindow swissprot:YBHF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBHF_ECOLI sigcleave swissprot:YBHF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBHF_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES SQUS_ECOLI Kinetic parameters KM=108 mM for D-mannose {ECO 0000269|PubMed 18328504}; KM=276 mM for D-fructose {ECO 0000269|PubMed 18328504}; KM=405 mM for D-lyxose {ECO 0000269|PubMed 18328504}; KM=163 mM for D-xylulose {ECO 0000269|PubMed 18328504}; Note=kcat is 25.3 sec(-1) for D-mannose. kcat is 22.2 sec(-1) for D-fructose. kcat is 13.5 sec(-1) for D-lyxose. kcat is 10.3 sec(-1) for D-xylulose.; pH dependence Optimum pH is 7. {ECO 0000269|PubMed 18328504}; Temperature dependence Optimum temperature is 47 degrees Celsius. {ECO 0000269|PubMed 18328504}; # BioGrid 4262638 4 # CATALYTIC ACTIVITY SQUS_ECOLI Sulfoquinovose = 6-deoxy-6-sulfo-D-fructose. {ECO 0000255|HAMAP-Rule MF_00998, ECO 0000269|PubMed 24463506}. # DISRUPTION PHENOTYPE Mutant fails to grow on sulfoquinovose as a sole carbon source. {ECO:0000269|PubMed 24463506}. # ENZYME REGULATION Significantly inhibited by Cu(2+), Fe(3+) and Co(2+). Partially inhibited by Mg(2+), Ca(2+) and Mn(2+). Also inhibited by ATP, ADP, dATP, TTP and GTP. {ECO:0000269|PubMed 18328504}. # EcoGene EG11845 yihS # FUNCTION SQUS_ECOLI Catalyzes the isomerization of sulfoquinovose (SQ) to 6- deoxy-6-sulfo-D-fructose (SF). In vitro, can also catalyze the interconversion of mannose, fructose and glucose, or lyxose and xylulose, but has extremely low activity with glucose. {ECO 0000255|HAMAP-Rule MF_00998, ECO 0000269|PubMed 18328504, ECO 0000269|PubMed 24463506}. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0050089 mannose isomerase activity; IDA:EcoCyc. # GO_function GO:0061593 sulfoquinovose isomerase activity; IDA:EcoCyc. # GO_process GO:1902777 6-sulfoquinovose(1-) catabolic process; IMP:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009056 catabolic process # Gene3D 1.50.10.10 -; 1. # HAMAP MF_00998 SQ_isomerase # INDUCTION Induced during growth with sulfoquinovose. {ECO:0000269|PubMed 24463506}. # InterPro IPR008928 6-hairpin_glycosidase-like # InterPro IPR012341 6hp_glycosidase # InterPro IPR030875 SQ_isomerase # Organism SQUS_ECOLI Escherichia coli (strain K12) # PATRIC 32123263 VBIEscCol129921_3992 # PDB 2RGK X-ray; 2.50 A; A/B/C/D/E/F=1-413 # PIR S40824 S40824 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Sulfoquinovose isomerase {ECO:0000255|HAMAP-Rule MF_00998} # RefSeq NP_418316 NC_000913.3 # RefSeq WP_000870916 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB03013.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the N-acylglucosamine 2-epimerase family. {ECO:0000255|HAMAP-Rule MF_00998}. # SUBUNIT SQUS_ECOLI Homohexamer. {ECO 0000255|HAMAP-Rule MF_00998, ECO 0000269|PubMed 18328504}. # SUPFAM SSF48208 SSF48208 # eggNOG COG2942 LUCA # eggNOG ENOG4107QKS Bacteria BLAST swissprot:SQUS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SQUS_ECOLI BioCyc ECOL316407:JW5569-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5569-MONOMER BioCyc EcoCyc:EG11845-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11845-MONOMER BioCyc MetaCyc:EG11845-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11845-MONOMER DOI 10.1016/j.jmb.2008.01.090 http://dx.doi.org/10.1016/j.jmb.2008.01.090 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature12947 http://dx.doi.org/10.1038/nature12947 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.3.1.31 {ECO:0000255|HAMAP-Rule:MF_00998} http://www.genome.jp/dbget-bin/www_bget?EC:5.3.1.31 {ECO:0000255|HAMAP-Rule:MF_00998} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 5.3.1.31 {ECO:0000255|HAMAP-Rule:MF_00998} http://enzyme.expasy.org/EC/5.3.1.31 {ECO:0000255|HAMAP-Rule:MF_00998} EchoBASE EB1791 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1791 EcoGene EG11845 http://www.ecogene.org/geneInfo.php?eg_id=EG11845 EnsemblBacteria AAD13442 http://www.ensemblgenomes.org/id/AAD13442 EnsemblBacteria AAD13442 http://www.ensemblgenomes.org/id/AAD13442 EnsemblBacteria BAE77429 http://www.ensemblgenomes.org/id/BAE77429 EnsemblBacteria BAE77429 http://www.ensemblgenomes.org/id/BAE77429 EnsemblBacteria BAE77429 http://www.ensemblgenomes.org/id/BAE77429 EnsemblBacteria b3880 http://www.ensemblgenomes.org/id/b3880 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0050089 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050089 GO_function GO:0061593 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061593 GO_process GO:1902777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902777 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 1.50.10.10 http://www.cathdb.info/version/latest/superfamily/1.50.10.10 GeneID 948374 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948374 HAMAP MF_00998 http://hamap.expasy.org/unirule/MF_00998 HOGENOM HOG000244284 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000244284&db=HOGENOM6 InParanoid P32140 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32140 IntEnz 5.3.1.31 {ECO:0000255|HAMAP-Rule:MF_00998} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.3.1.31 {ECO:0000255|HAMAP-Rule:MF_00998} InterPro IPR008928 http://www.ebi.ac.uk/interpro/entry/IPR008928 InterPro IPR012341 http://www.ebi.ac.uk/interpro/entry/IPR012341 InterPro IPR030875 http://www.ebi.ac.uk/interpro/entry/IPR030875 KEGG_Gene ecj:JW5569 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5569 KEGG_Gene eco:b3880 http://www.genome.jp/dbget-bin/www_bget?eco:b3880 OMA ANMHMTE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ANMHMTE PDB 2RGK http://www.ebi.ac.uk/pdbe-srv/view/entry/2RGK PDBsum 2RGK http://www.ebi.ac.uk/pdbsum/2RGK PSORT swissprot:SQUS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SQUS_ECOLI PSORT-B swissprot:SQUS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SQUS_ECOLI PSORT2 swissprot:SQUS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SQUS_ECOLI Phobius swissprot:SQUS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SQUS_ECOLI ProteinModelPortal P32140 http://www.proteinmodelportal.org/query/uniprot/P32140 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18328504 http://www.ncbi.nlm.nih.gov/pubmed/18328504 PubMed 24463506 http://www.ncbi.nlm.nih.gov/pubmed/24463506 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418316 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418316 RefSeq WP_000870916 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000870916 SMR P32140 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32140 STRING 511145.b3880 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3880&targetmode=cogs SUPFAM SSF48208 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48208 UniProtKB SQUS_ECOLI http://www.uniprot.org/uniprot/SQUS_ECOLI UniProtKB-AC P32140 http://www.uniprot.org/uniprot/P32140 charge swissprot:SQUS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SQUS_ECOLI eggNOG COG2942 http://eggnogapi.embl.de/nog_data/html/tree/COG2942 eggNOG ENOG4107QKS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QKS epestfind swissprot:SQUS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SQUS_ECOLI garnier swissprot:SQUS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SQUS_ECOLI helixturnhelix swissprot:SQUS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SQUS_ECOLI hmoment swissprot:SQUS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SQUS_ECOLI iep swissprot:SQUS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SQUS_ECOLI inforesidue swissprot:SQUS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SQUS_ECOLI octanol swissprot:SQUS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SQUS_ECOLI pepcoil swissprot:SQUS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SQUS_ECOLI pepdigest swissprot:SQUS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SQUS_ECOLI pepinfo swissprot:SQUS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SQUS_ECOLI pepnet swissprot:SQUS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SQUS_ECOLI pepstats swissprot:SQUS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SQUS_ECOLI pepwheel swissprot:SQUS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SQUS_ECOLI pepwindow swissprot:SQUS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SQUS_ECOLI sigcleave swissprot:SQUS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SQUS_ECOLI ## Database ID URL or Descriptions # BioGrid 4263438 8 # DOMAIN TRKA_ECOLI The RCK N-terminal domain binds NAD and possibly other effectors. This is expected to cause a conformation change that regulates potassium transport (By similarity). {ECO 0000250}. # EcoGene EG11019 trkA # FUNCTION TRKA_ECOLI Part of the constitutive potassium transport systems TrkG and TrkH. May regulate the transport activity of TrkG and TrkH systems. Binds to NAD(+) and NADH. {ECO 0000269|PubMed 2674131, ECO 0000269|PubMed 8412700}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016020 membrane; IDA:EcoCyc. # GO_function GO:0004497 monooxygenase activity; IBA:GO_Central. # GO_function GO:0008324 cation transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0015079 potassium ion transmembrane transporter activity; IEA:InterPro. # GO_process GO:0006813 potassium ion transport; IDA:EcoCyc. # GO_process GO:0044550 secondary metabolite biosynthetic process; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0019748 secondary metabolic process # Gene3D 3.40.50.720 -; 2. # IntAct P0AGI8 4 # InterPro IPR003148 RCK_N # InterPro IPR006036 K_uptake_TrkA # InterPro IPR006037 RCK_C # InterPro IPR016040 NAD(P)-bd_dom # Organism TRKA_ECOLI Escherichia coli (strain K12) # PATRIC 32122012 VBIEscCol129921_3383 # PIR S36252 S36252 # PRINTS PR00335 KUPTAKETRKA # PROSITE PS51201 RCK_N; 2 # PROSITE PS51202 RCK_C; 2 # Pfam PF02080 TrkA_C; 2 # Pfam PF02254 TrkA_N; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TRKA_ECOLI Trk system potassium uptake protein TrkA # RefSeq NP_417748 NC_000913.3 # RefSeq WP_000691382 NZ_LN832404.1 # SIMILARITY Contains 2 RCK C-terminal domains. {ECO:0000255|PROSITE-ProRule PRU00544}. # SIMILARITY Contains 2 RCK N-terminal domains. {ECO:0000255|PROSITE-ProRule PRU00543}. # SUBCELLULAR LOCATION TRKA_ECOLI Cell inner membrane {ECO 0000269|PubMed 2674131}; Peripheral membrane protein {ECO 0000269|PubMed 2674131}; Cytoplasmic side {ECO 0000269|PubMed 2674131}. Note=Peripherally bound to the inner side of the inner membrane via the TrkG and TrkH proteins. # SUPFAM SSF116726 SSF116726; 2 # SUPFAM SSF51735 SSF51735; 2 # TCDB 2.A.38.1 the k(+) transporter (trk) family # eggNOG COG0569 LUCA # eggNOG ENOG4105C1A Bacteria BLAST swissprot:TRKA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRKA_ECOLI BioCyc ECOL316407:JW3251-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3251-MONOMER BioCyc EcoCyc:TRKA-MONOMER http://biocyc.org/getid?id=EcoCyc:TRKA-MONOMER COG COG0569 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0569 DIP DIP-35971N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35971N DOI 10.1006/jmbi.1996.0835 http://dx.doi.org/10.1006/jmbi.1996.0835 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1993.tb01714.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb01714.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X52114 http://www.ebi.ac.uk/ena/data/view/X52114 EMBL X77091 http://www.ebi.ac.uk/ena/data/view/X77091 EMBL Y10307 http://www.ebi.ac.uk/ena/data/view/Y10307 EchoBASE EB1012 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1012 EcoGene EG11019 http://www.ecogene.org/geneInfo.php?eg_id=EG11019 EnsemblBacteria AAC76315 http://www.ensemblgenomes.org/id/AAC76315 EnsemblBacteria AAC76315 http://www.ensemblgenomes.org/id/AAC76315 EnsemblBacteria BAE78002 http://www.ensemblgenomes.org/id/BAE78002 EnsemblBacteria BAE78002 http://www.ensemblgenomes.org/id/BAE78002 EnsemblBacteria BAE78002 http://www.ensemblgenomes.org/id/BAE78002 EnsemblBacteria b3290 http://www.ensemblgenomes.org/id/b3290 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0004497 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004497 GO_function GO:0008324 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008324 GO_function GO:0015079 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015079 GO_process GO:0006813 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813 GO_process GO:0044550 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044550 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0019748 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019748 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 947788 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947788 HOGENOM HOG000227130 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000227130&db=HOGENOM6 InParanoid P0AGI8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGI8 IntAct P0AGI8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AGI8* InterPro IPR003148 http://www.ebi.ac.uk/interpro/entry/IPR003148 InterPro IPR006036 http://www.ebi.ac.uk/interpro/entry/IPR006036 InterPro IPR006037 http://www.ebi.ac.uk/interpro/entry/IPR006037 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 KEGG_Gene ecj:JW3251 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3251 KEGG_Gene eco:b3290 http://www.genome.jp/dbget-bin/www_bget?eco:b3290 KEGG_Orthology KO:K03499 http://www.genome.jp/dbget-bin/www_bget?KO:K03499 OMA IACQVAY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IACQVAY PRINTS PR00335 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00335 PROSITE PS51201 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51201 PROSITE PS51202 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51202 PSORT swissprot:TRKA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRKA_ECOLI PSORT-B swissprot:TRKA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRKA_ECOLI PSORT2 swissprot:TRKA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRKA_ECOLI Pfam PF02080 http://pfam.xfam.org/family/PF02080 Pfam PF02254 http://pfam.xfam.org/family/PF02254 Phobius swissprot:TRKA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRKA_ECOLI PhylomeDB P0AGI8 http://phylomedb.org/?seqid=P0AGI8 ProteinModelPortal P0AGI8 http://www.proteinmodelportal.org/query/uniprot/P0AGI8 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2674131 http://www.ncbi.nlm.nih.gov/pubmed/2674131 PubMed 7961514 http://www.ncbi.nlm.nih.gov/pubmed/7961514 PubMed 8412700 http://www.ncbi.nlm.nih.gov/pubmed/8412700 PubMed 9086272 http://www.ncbi.nlm.nih.gov/pubmed/9086272 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417748 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417748 RefSeq WP_000691382 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000691382 SMR P0AGI8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AGI8 STRING 511145.b3290 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3290&targetmode=cogs STRING COG0569 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0569&targetmode=cogs SUPFAM SSF116726 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF116726 SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 TCDB 2.A.38.1 http://www.tcdb.org/search/result.php?tc=2.A.38.1 UniProtKB TRKA_ECOLI http://www.uniprot.org/uniprot/TRKA_ECOLI UniProtKB-AC P0AGI8 http://www.uniprot.org/uniprot/P0AGI8 charge swissprot:TRKA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRKA_ECOLI eggNOG COG0569 http://eggnogapi.embl.de/nog_data/html/tree/COG0569 eggNOG ENOG4105C1A http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C1A epestfind swissprot:TRKA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRKA_ECOLI garnier swissprot:TRKA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRKA_ECOLI helixturnhelix swissprot:TRKA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRKA_ECOLI hmoment swissprot:TRKA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRKA_ECOLI iep swissprot:TRKA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRKA_ECOLI inforesidue swissprot:TRKA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRKA_ECOLI octanol swissprot:TRKA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRKA_ECOLI pepcoil swissprot:TRKA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRKA_ECOLI pepdigest swissprot:TRKA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRKA_ECOLI pepinfo swissprot:TRKA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRKA_ECOLI pepnet swissprot:TRKA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRKA_ECOLI pepstats swissprot:TRKA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRKA_ECOLI pepwheel swissprot:TRKA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRKA_ECOLI pepwindow swissprot:TRKA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRKA_ECOLI sigcleave swissprot:TRKA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRKA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260975 12 # EcoGene EG12604 yjhU # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_function GO:0016987 sigma factor activity; IEA:InterPro. # GO_function GO:0030246 carbohydrate binding; IEA:InterPro. # GO_process GO:0006352 DNA-templated transcription, initiation; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0000988 transcription factor activity, protein binding # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # InterPro IPR007324 Sugar-bd_dom_put # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR013324 RNA_pol_sigma_r3_r4 # Organism YJHU_ECOLI Escherichia coli (strain K12) # PATRIC 32124174 VBIEscCol129921_4430 # PIR S56520 S56520 # Pfam PF04198 Sugar-bind # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJHU_ECOLI Uncharacterized transcriptional regulator YjhU # RefSeq NP_418715 NC_000913.3 # RefSeq WP_000373366 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97191.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the SorC transcriptional regulatory family. {ECO 0000305}. # SUPFAM SSF88659 SSF88659 # eggNOG COG2390 LUCA # eggNOG ENOG4105DKT Bacteria BLAST swissprot:YJHU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJHU_ECOLI BioCyc ECOL316407:JW5952-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5952-MONOMER BioCyc EcoCyc:G7909-MONOMER http://biocyc.org/getid?id=EcoCyc:G7909-MONOMER DIP DIP-12629N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12629N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2488 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2488 EcoGene EG12604 http://www.ecogene.org/geneInfo.php?eg_id=EG12604 EnsemblBacteria AAC77251 http://www.ensemblgenomes.org/id/AAC77251 EnsemblBacteria AAC77251 http://www.ensemblgenomes.org/id/AAC77251 EnsemblBacteria BAE78286 http://www.ensemblgenomes.org/id/BAE78286 EnsemblBacteria BAE78286 http://www.ensemblgenomes.org/id/BAE78286 EnsemblBacteria BAE78286 http://www.ensemblgenomes.org/id/BAE78286 EnsemblBacteria b4295 http://www.ensemblgenomes.org/id/b4295 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0016987 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016987 GO_function GO:0030246 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030246 GO_process GO:0006352 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006352 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0000988 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000988 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 948827 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948827 HOGENOM HOG000054887 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000054887&db=HOGENOM6 InParanoid P39356 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39356 InterPro IPR007324 http://www.ebi.ac.uk/interpro/entry/IPR007324 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR013324 http://www.ebi.ac.uk/interpro/entry/IPR013324 KEGG_Gene ecj:JW5952 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5952 KEGG_Gene eco:b4295 http://www.genome.jp/dbget-bin/www_bget?eco:b4295 OMA MYYLQDL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MYYLQDL PSORT swissprot:YJHU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJHU_ECOLI PSORT-B swissprot:YJHU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJHU_ECOLI PSORT2 swissprot:YJHU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJHU_ECOLI Pfam PF04198 http://pfam.xfam.org/family/PF04198 Phobius swissprot:YJHU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJHU_ECOLI PhylomeDB P39356 http://phylomedb.org/?seqid=P39356 ProteinModelPortal P39356 http://www.proteinmodelportal.org/query/uniprot/P39356 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418715 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418715 RefSeq WP_000373366 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000373366 SMR P39356 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39356 STRING 511145.b4295 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4295&targetmode=cogs SUPFAM SSF88659 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF88659 UniProtKB YJHU_ECOLI http://www.uniprot.org/uniprot/YJHU_ECOLI UniProtKB-AC P39356 http://www.uniprot.org/uniprot/P39356 charge swissprot:YJHU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJHU_ECOLI eggNOG COG2390 http://eggnogapi.embl.de/nog_data/html/tree/COG2390 eggNOG ENOG4105DKT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DKT epestfind swissprot:YJHU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJHU_ECOLI garnier swissprot:YJHU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJHU_ECOLI helixturnhelix swissprot:YJHU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJHU_ECOLI hmoment swissprot:YJHU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJHU_ECOLI iep swissprot:YJHU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJHU_ECOLI inforesidue swissprot:YJHU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJHU_ECOLI octanol swissprot:YJHU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJHU_ECOLI pepcoil swissprot:YJHU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJHU_ECOLI pepdigest swissprot:YJHU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJHU_ECOLI pepinfo swissprot:YJHU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJHU_ECOLI pepnet swissprot:YJHU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJHU_ECOLI pepstats swissprot:YJHU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJHU_ECOLI pepwheel swissprot:YJHU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJHU_ECOLI pepwindow swissprot:YJHU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJHU_ECOLI sigcleave swissprot:YJHU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJHU_ECOLI ## Database ID URL or Descriptions # BioGrid 4259510 11 # DOMAIN NUSG_ECOLI The N-terminal domain interacts with RNAP and the C- terminal domain binds either to Rho or to RpsJ (NusE). These domains are separated by a flexible linker. {ECO 0000269|PubMed 20413501}. # EcoGene EG10667 nusG # FUNCTION NUSG_ECOLI Participates in transcription elongation, termination and antitermination. In the absence of Rho, increases the rate of transcription elongation by the RNA polymerase (RNAP), probably by partially suppressing pausing. In the presence of Rho, modulates most Rho-dependent termination events by interacting with the RNAP to render the complex more susceptible to the termination activity of Rho. May be required to overcome a kinetic limitation of Rho to function at certain terminators. Also involved in ribosomal RNA and phage lambda N-mediated transcriptional antitermination. {ECO 0000255|HAMAP-Rule MF_00948, ECO 0000269|PubMed 10383769, ECO 0000269|PubMed 10820031, ECO 0000269|PubMed 14973028, ECO 0000269|PubMed 1532577, ECO 0000269|PubMed 1547498, ECO 0000269|PubMed 7505669, ECO 0000269|PubMed 7761393, ECO 0000269|PubMed 7868616, ECO 0000269|PubMed 8422985}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_process GO:0006353 DNA-templated transcription, termination; IDA:EcoCyc. # GO_process GO:0006354 DNA-templated transcription, elongation; IEA:UniProtKB-HAMAP. # GO_process GO:0031564 transcription antitermination; IDA:EcoCyc. # GO_process GO:0032784 regulation of DNA-templated transcription, elongation; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 2.30.30.30 -; 1. # Gene3D 3.30.70.940 -; 1. # HAMAP MF_00948 NusG # INTERACTION NUSG_ECOLI P0ACJ8 crp; NbExp=2; IntAct=EBI-369628, EBI-547513; P0AG30 rho; NbExp=6; IntAct=EBI-369628, EBI-545468; # IntAct P0AFG0 54 # InterPro IPR001062 Transcrpt_antiterm_NusG # InterPro IPR005824 KOW # InterPro IPR006645 NGN_dom # InterPro IPR008991 Translation_prot_SH3-like # InterPro IPR014722 Rib_L2_dom2 # InterPro IPR015869 Transcrpt_antiterm_NusG_bac_CS # KEGG_Brite ko03009 Ribosome biogenesis # KEGG_Brite ko03021 Transcription machinery # Organism NUSG_ECOLI Escherichia coli (strain K12) # PATRIC 32123485 VBIEscCol129921_4095 # PDB 2JVV NMR; -; A=1-181 # PDB 2K06 NMR; -; A=1-123 # PDB 2KVQ NMR; -; G=123-181 # PIR B35139 TWECNG # PRINTS PR00338 NUSGTNSCPFCT # PROSITE PS01014 NUSG # Pfam PF00467 KOW # Pfam PF02357 NusG # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Transcription termination/antitermination protein NusG {ECO:0000255|HAMAP-Rule MF_00948} # RefSeq NP_418409 NC_000913.3 # RefSeq WP_001287516 NZ_LN832404.1 # SIMILARITY Belongs to the NusG family. {ECO:0000255|HAMAP- Rule MF_00948}. # SIMILARITY Contains 1 KOW domain. {ECO:0000255|HAMAP- Rule MF_00948}. # SMART SM00738 NGN # SMART SM00739 KOW # SUBUNIT NUSG_ECOLI Monomer. Interacts with the transcription termination factor Rho and with RNA polymerase. One NusG monomer forms a stable complex with a Rho hexamer. Binds directly, but weakly, to the core enzyme of RNAP. Also interacts with RpsJ (NusE). {ECO 0000255|HAMAP-Rule MF_00948, ECO 0000269|PubMed 10820031, ECO 0000269|PubMed 1532577, ECO 0000269|PubMed 20413501, ECO 0000269|PubMed 8422985}. # SUPFAM SSF50104 SSF50104 # SUPFAM SSF82679 SSF82679 # TIGRFAMs TIGR00922 nusG # eggNOG COG0250 LUCA # eggNOG ENOG4105E5V Bacteria BLAST swissprot:NUSG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NUSG_ECOLI BioCyc ECOL316407:JW3945-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3945-MONOMER BioCyc EcoCyc:EG10667-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10667-MONOMER COG COG0250 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0250 DIP DIP-31860N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31860N DOI 10.1006/jmbi.1998.1726 http://dx.doi.org/10.1006/jmbi.1998.1726 DOI 10.1016/0092-8674(92)90041-A http://dx.doi.org/10.1016/0092-8674(92)90041-A DOI 10.1021/bi992658z http://dx.doi.org/10.1021/bi992658z DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1999.01442.x http://dx.doi.org/10.1046/j.1365-2958.1999.01442.x DOI 10.1073/pnas.92.11.4738 http://dx.doi.org/10.1073/pnas.92.11.4738 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1101/gad.7.1.161 http://dx.doi.org/10.1101/gad.7.1.161 DOI 10.1126/science.1184953 http://dx.doi.org/10.1126/science.1184953 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.186.5.1304-1310.2004 http://dx.doi.org/10.1128/JB.186.5.1304-1310.2004 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M30610 http://www.ebi.ac.uk/ena/data/view/M30610 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0661 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0661 EcoGene EG10667 http://www.ecogene.org/geneInfo.php?eg_id=EG10667 EnsemblBacteria AAC76956 http://www.ensemblgenomes.org/id/AAC76956 EnsemblBacteria AAC76956 http://www.ensemblgenomes.org/id/AAC76956 EnsemblBacteria BAE77338 http://www.ensemblgenomes.org/id/BAE77338 EnsemblBacteria BAE77338 http://www.ensemblgenomes.org/id/BAE77338 EnsemblBacteria BAE77338 http://www.ensemblgenomes.org/id/BAE77338 EnsemblBacteria b3982 http://www.ensemblgenomes.org/id/b3982 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_process GO:0006353 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006353 GO_process GO:0006354 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006354 GO_process GO:0031564 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031564 GO_process GO:0032784 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032784 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 2.30.30.30 http://www.cathdb.info/version/latest/superfamily/2.30.30.30 Gene3D 3.30.70.940 http://www.cathdb.info/version/latest/superfamily/3.30.70.940 GeneID 948485 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948485 HAMAP MF_00948 http://hamap.expasy.org/unirule/MF_00948 HOGENOM HOG000219264 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219264&db=HOGENOM6 InParanoid P0AFG0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFG0 IntAct P0AFG0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFG0* InterPro IPR001062 http://www.ebi.ac.uk/interpro/entry/IPR001062 InterPro IPR005824 http://www.ebi.ac.uk/interpro/entry/IPR005824 InterPro IPR006645 http://www.ebi.ac.uk/interpro/entry/IPR006645 InterPro IPR008991 http://www.ebi.ac.uk/interpro/entry/IPR008991 InterPro IPR014722 http://www.ebi.ac.uk/interpro/entry/IPR014722 InterPro IPR015869 http://www.ebi.ac.uk/interpro/entry/IPR015869 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Brite ko03021 http://www.genome.jp/dbget-bin/www_bget?ko03021 KEGG_Gene ecj:JW3945 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3945 KEGG_Gene eco:b3982 http://www.genome.jp/dbget-bin/www_bget?eco:b3982 KEGG_Orthology KO:K02601 http://www.genome.jp/dbget-bin/www_bget?KO:K02601 MINT MINT-1218205 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1218205 OMA AVHTYVG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AVHTYVG PDB 2JVV http://www.ebi.ac.uk/pdbe-srv/view/entry/2JVV PDB 2K06 http://www.ebi.ac.uk/pdbe-srv/view/entry/2K06 PDB 2KVQ http://www.ebi.ac.uk/pdbe-srv/view/entry/2KVQ PDBsum 2JVV http://www.ebi.ac.uk/pdbsum/2JVV PDBsum 2K06 http://www.ebi.ac.uk/pdbsum/2K06 PDBsum 2KVQ http://www.ebi.ac.uk/pdbsum/2KVQ PRINTS PR00338 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00338 PROSITE PS01014 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01014 PSORT swissprot:NUSG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NUSG_ECOLI PSORT-B swissprot:NUSG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NUSG_ECOLI PSORT2 swissprot:NUSG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NUSG_ECOLI Pfam PF00467 http://pfam.xfam.org/family/PF00467 Pfam PF02357 http://pfam.xfam.org/family/PF02357 Phobius swissprot:NUSG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NUSG_ECOLI PhylomeDB P0AFG0 http://phylomedb.org/?seqid=P0AFG0 ProteinModelPortal P0AFG0 http://www.proteinmodelportal.org/query/uniprot/P0AFG0 PubMed 10383769 http://www.ncbi.nlm.nih.gov/pubmed/10383769 PubMed 10820031 http://www.ncbi.nlm.nih.gov/pubmed/10820031 PubMed 14973028 http://www.ncbi.nlm.nih.gov/pubmed/14973028 PubMed 1532577 http://www.ncbi.nlm.nih.gov/pubmed/1532577 PubMed 1547498 http://www.ncbi.nlm.nih.gov/pubmed/1547498 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20413501 http://www.ncbi.nlm.nih.gov/pubmed/20413501 PubMed 2137819 http://www.ncbi.nlm.nih.gov/pubmed/2137819 PubMed 7505669 http://www.ncbi.nlm.nih.gov/pubmed/7505669 PubMed 7761393 http://www.ncbi.nlm.nih.gov/pubmed/7761393 PubMed 7868616 http://www.ncbi.nlm.nih.gov/pubmed/7868616 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 8422985 http://www.ncbi.nlm.nih.gov/pubmed/8422985 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 RefSeq NP_418409 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418409 RefSeq WP_001287516 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001287516 SMART SM00738 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00738 SMART SM00739 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00739 SMR P0AFG0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFG0 STRING 511145.b3982 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3982&targetmode=cogs STRING COG0250 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0250&targetmode=cogs SUPFAM SSF50104 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50104 SUPFAM SSF82679 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF82679 SWISS-2DPAGE P0AFG0 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AFG0 TIGRFAMs TIGR00922 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00922 UniProtKB NUSG_ECOLI http://www.uniprot.org/uniprot/NUSG_ECOLI UniProtKB-AC P0AFG0 http://www.uniprot.org/uniprot/P0AFG0 charge swissprot:NUSG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NUSG_ECOLI eggNOG COG0250 http://eggnogapi.embl.de/nog_data/html/tree/COG0250 eggNOG ENOG4105E5V http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E5V epestfind swissprot:NUSG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NUSG_ECOLI garnier swissprot:NUSG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NUSG_ECOLI helixturnhelix swissprot:NUSG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NUSG_ECOLI hmoment swissprot:NUSG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NUSG_ECOLI iep swissprot:NUSG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NUSG_ECOLI inforesidue swissprot:NUSG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NUSG_ECOLI octanol swissprot:NUSG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NUSG_ECOLI pepcoil swissprot:NUSG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NUSG_ECOLI pepdigest swissprot:NUSG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NUSG_ECOLI pepinfo swissprot:NUSG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NUSG_ECOLI pepnet swissprot:NUSG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NUSG_ECOLI pepstats swissprot:NUSG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NUSG_ECOLI pepwheel swissprot:NUSG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NUSG_ECOLI pepwindow swissprot:NUSG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NUSG_ECOLI sigcleave swissprot:NUSG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NUSG_ECOLI ## Database ID URL or Descriptions # BioGrid 4259573 6 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # IntAct P75971 2 # Organism Y1142_ECOLI Escherichia coli (strain K12) # PIR C64859 C64859 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Y1142_ECOLI Putative uncharacterized protein b1142 # SUBCELLULAR LOCATION Y1142_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. BLAST swissprot:Y1142_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:Y1142_ECOLI BioCyc ECOL316407:JW1128-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1128-MONOMER BioCyc EcoCyc:G6586-MONOMER http://biocyc.org/getid?id=EcoCyc:G6586-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EnsemblBacteria BAE76377 http://www.ensemblgenomes.org/id/BAE76377 EnsemblBacteria BAE76377 http://www.ensemblgenomes.org/id/BAE76377 EnsemblBacteria BAE76377 http://www.ensemblgenomes.org/id/BAE76377 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 IntAct P75971 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75971* KEGG_Gene ecj:JW1128 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1128 PSORT swissprot:Y1142_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:Y1142_ECOLI PSORT-B swissprot:Y1142_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:Y1142_ECOLI PSORT2 swissprot:Y1142_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:Y1142_ECOLI Phobius swissprot:Y1142_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:Y1142_ECOLI ProteinModelPortal P75971 http://www.proteinmodelportal.org/query/uniprot/P75971 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 STRING 316407.85674846 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85674846&targetmode=cogs UniProtKB Y1142_ECOLI http://www.uniprot.org/uniprot/Y1142_ECOLI UniProtKB-AC P75971 http://www.uniprot.org/uniprot/P75971 charge swissprot:Y1142_ECOLI http://rest.g-language.org/emboss/charge/swissprot:Y1142_ECOLI epestfind swissprot:Y1142_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:Y1142_ECOLI garnier swissprot:Y1142_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:Y1142_ECOLI helixturnhelix swissprot:Y1142_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:Y1142_ECOLI hmoment swissprot:Y1142_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:Y1142_ECOLI iep swissprot:Y1142_ECOLI http://rest.g-language.org/emboss/iep/swissprot:Y1142_ECOLI inforesidue swissprot:Y1142_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:Y1142_ECOLI octanol swissprot:Y1142_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:Y1142_ECOLI pepcoil swissprot:Y1142_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:Y1142_ECOLI pepdigest swissprot:Y1142_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:Y1142_ECOLI pepinfo swissprot:Y1142_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:Y1142_ECOLI pepnet swissprot:Y1142_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:Y1142_ECOLI pepstats swissprot:Y1142_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:Y1142_ECOLI pepwheel swissprot:Y1142_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:Y1142_ECOLI pepwindow swissprot:Y1142_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:Y1142_ECOLI sigcleave swissprot:Y1142_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:Y1142_ECOLI ## Database ID URL or Descriptions # BioGrid 4259585 137 # DISRUPTION PHENOTYPE Loss of plasmid silencing (PubMed:21255106). {ECO 0000269|PubMed:21255106}. # DOMAIN CAS2_ECOLI Substrate DNA-binding induces large structural changes that generate a surface for DNA-binding across the Cas2 dimer and formation of an optimal catalytic site (PubMed 26478180). {ECO 0000269|PubMed 26478180}. # EcoGene EG12845 ygbF # FUNCTION CAS2_ECOLI CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids) (PubMed 21255106, PubMed 24920831, PubMed 24793649). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). The Cas1-Cas2 complex is involved in CRISPR adaptation, the first stage of CRISPR immunity, being required for the addition/removal of CRISPR spacers at the leader end of the CRISPR locus (PubMed 24920831, PubMed 25707795, PubMed 24793649). The Cas1-Cas2 complex introduces staggered nicks into both strands of the CRISPR array near the leader repeat and joins the 5'-ends of the repeat strands with the 3'-ends of the new spacer sequence (PubMed 24920831). Spacer DNA integration requires supercoiled target DNA and 3'-OH ends on the inserted (spacer) DNA and probably initiates with a nucleophilic attack of the C 3'-OH end of the protospacer on the minus strand of the first repeat sequence (PubMed 25707795). Expression of Cas1-Cas2 in a strain lacking both genes permits spacer acquisition (PubMed 24793649, PubMed 24920831). Cas2 not seen to bind DNA alone; the Cas1-Cas2 complex preferentially binds CRISPR-locus DNA (PubMed 24793649). Highest binding is seen to a dual forked DNA complex with 3'-overhangs and a protospacer-adjacent motif- complement specifically positioned (PubMed 26478180). The protospacer DNA lies across a flat surface extending from 1 Cas1 dimer, across the Cas2 dimer and contacting the other Cas1 dimer; the 23 bp-long ds section of the DNA is bracketed by 1 Tyr-22 from each of the Cas1 dimers (PubMed 26478180, PubMed 26503043). Cas1 cuts within the 3'-overhang, to generate a 33-nucleotide DNA that is probably incorporated into the CRISPR leader by a cut-and-paste mechanism (PubMed 26478180). This subunit's probable nuclease activity is not required for spacer acquisition (PubMed 24793649). {ECO 0000269|PubMed 21255106, ECO 0000269|PubMed 24793649, ECO 0000269|PubMed 24920831, ECO 0000269|PubMed 26478180}. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004519 endonuclease activity; IEA:UniProtKB-KW. # GO_process GO:0043571 maintenance of CRISPR repeat elements; IMP:EcoCyc. # GO_process GO:0051607 defense response to virus; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004518 nuclease activity # GOslim_process GO:0002376 immune system process # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0044403 symbiosis, encompassing mutualism through parasitism # GOslim_process GO:0051276 chromosome organization # INDUCTION CAS2_ECOLI Repressed by H-NS (PubMed 20132443). Activated by LeuO (PubMed 19429622). Activated by the BaeSR two-component regulatory system, possibly due to envelope stress (PubMed 21255106). Part of the casABCDE-ygbT-ygbF operon (PubMed 19429622). {ECO 0000269|PubMed 19429622, ECO 0000269|PubMed 20132443, ECO 0000269|PubMed 21255106}. # IntAct P45956 2 # InterPro IPR010152 CRISPR-assoc_prot_Cas2_sub # Organism CAS2_ECOLI Escherichia coli (strain K12) # PATRIC 32120918 VBIEscCol129921_2851 # PDB 4MAK X-ray; 1.10 A; A/B=1-94 # PDB 4P6I X-ray; 2.30 A; A/B=1-94 # PDB 4QDL X-ray; 2.70 A; E/F=1-94 # PDB 5DLJ X-ray; 2.60 A; E/F=1-78 # PDB 5DQT X-ray; 3.10 A; E/F/M/N=1-94 # PDB 5DQU X-ray; 4.50 A; E/F=1-94 # PDB 5DQZ X-ray; 2.70 A; E/F=1-94 # PDB 5DS4 X-ray; 3.20 A; E/F=1-94 # PDB 5DS5 X-ray; 2.95 A; E/F=1-94 # PDB 5DS6 X-ray; 3.35 A; E/F=1-94 # PIR F65056 F65056 # Pfam PF09707 Cas_Cas2CT1978 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CAS2_ECOLI CRISPR-associated endoribonuclease Cas2 # RefSeq NP_417234 NC_000913.3 # RefSeq WP_001381369 NZ_LN832404.1 # SIMILARITY Belongs to the CRISPR-associated endoribonuclease Cas2 protein family. E.coli-subtype subfamily. {ECO 0000305}. # SUBUNIT CAS2_ECOLI Homodimer (Ref.10). Part of the Cas1-Cas2 complex (PubMed 24920831, PubMed 24793649, PubMed 25707795, Ref.12, PubMed 26478180, PubMed 26503043). Forms a hexamer with 2 Cas1 dimers sandwiching a Cas2 dimer (PubMed 24793649). The DNA lies across a flat surface extending from 1 Cas1 dimer, across the Cas2 dimer and contacting the other Cas1 dimer. Only 1 Cas1 protein from each dimer is catalytic, the other interacts with the Cas2 dimer and possibly target DNA (PubMed 26478180, PubMed 26503043). {ECO 0000269|PubMed 24793649, ECO 0000269|PubMed 24920831, ECO 0000269|PubMed 25707795, ECO 0000269|PubMed 26478180, ECO 0000269|PubMed 26503043, ECO 0000305|Ref.10, ECO 0000305|Ref.12}. # TIGRFAMs TIGR01873 cas_CT1978 # eggNOG ENOG4105PWE Bacteria # eggNOG ENOG4111VHR LUCA BLAST swissprot:CAS2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CAS2_ECOLI BioCyc ECOL316407:JW5438-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5438-MONOMER BioCyc EcoCyc:EG12845-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12845-MONOMER DIP DIP-12109N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12109N DOI 10.1016/j.cell.2015.10.008 http://dx.doi.org/10.1016/j.cell.2015.10.008 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature14237 http://dx.doi.org/10.1038/nature14237 DOI 10.1038/nature15760 http://dx.doi.org/10.1038/nature15760 DOI 10.1038/nsmb.2820 http://dx.doi.org/10.1038/nsmb.2820 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1093/nar/gku510 http://dx.doi.org/10.1093/nar/gku510 DOI 10.1111/j.1365-2958.2010.07073.x http://dx.doi.org/10.1111/j.1365-2958.2010.07073.x DOI 10.1111/j.1365-2958.2010.07482.x http://dx.doi.org/10.1111/j.1365-2958.2010.07482.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00108-09 http://dx.doi.org/10.1128/JB.00108-09 EC_number EC:3.1.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M27059 http://www.ebi.ac.uk/ena/data/view/M27059 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 ENZYME 3.1.-.- http://enzyme.expasy.org/EC/3.1.-.- EchoBASE EB2694 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2694 EcoGene EG12845 http://www.ecogene.org/geneInfo.php?eg_id=EG12845 EnsemblBacteria AAC75796 http://www.ensemblgenomes.org/id/AAC75796 EnsemblBacteria AAC75796 http://www.ensemblgenomes.org/id/AAC75796 EnsemblBacteria BAE76831 http://www.ensemblgenomes.org/id/BAE76831 EnsemblBacteria BAE76831 http://www.ensemblgenomes.org/id/BAE76831 EnsemblBacteria BAE76831 http://www.ensemblgenomes.org/id/BAE76831 EnsemblBacteria b2754 http://www.ensemblgenomes.org/id/b2754 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004519 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004519 GO_process GO:0043571 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043571 GO_process GO:0051607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051607 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_process GO:0002376 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0044403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403 GOslim_process GO:0051276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051276 GeneID 947213 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947213 HOGENOM HOG000015873 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000015873&db=HOGENOM6 InParanoid P45956 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45956 IntAct P45956 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45956* IntEnz 3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1 InterPro IPR010152 http://www.ebi.ac.uk/interpro/entry/IPR010152 KEGG_Gene ecj:JW5438 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5438 KEGG_Gene eco:b2754 http://www.genome.jp/dbget-bin/www_bget?eco:b2754 OMA GENRRMP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GENRRMP PDB 4MAK http://www.ebi.ac.uk/pdbe-srv/view/entry/4MAK PDB 4P6I http://www.ebi.ac.uk/pdbe-srv/view/entry/4P6I PDB 4QDL http://www.ebi.ac.uk/pdbe-srv/view/entry/4QDL PDB 5DLJ http://www.ebi.ac.uk/pdbe-srv/view/entry/5DLJ PDB 5DQT http://www.ebi.ac.uk/pdbe-srv/view/entry/5DQT PDB 5DQU http://www.ebi.ac.uk/pdbe-srv/view/entry/5DQU PDB 5DQZ http://www.ebi.ac.uk/pdbe-srv/view/entry/5DQZ PDB 5DS4 http://www.ebi.ac.uk/pdbe-srv/view/entry/5DS4 PDB 5DS5 http://www.ebi.ac.uk/pdbe-srv/view/entry/5DS5 PDB 5DS6 http://www.ebi.ac.uk/pdbe-srv/view/entry/5DS6 PDBsum 4MAK http://www.ebi.ac.uk/pdbsum/4MAK PDBsum 4P6I http://www.ebi.ac.uk/pdbsum/4P6I PDBsum 4QDL http://www.ebi.ac.uk/pdbsum/4QDL PDBsum 5DLJ http://www.ebi.ac.uk/pdbsum/5DLJ PDBsum 5DQT http://www.ebi.ac.uk/pdbsum/5DQT PDBsum 5DQU http://www.ebi.ac.uk/pdbsum/5DQU PDBsum 5DQZ http://www.ebi.ac.uk/pdbsum/5DQZ PDBsum 5DS4 http://www.ebi.ac.uk/pdbsum/5DS4 PDBsum 5DS5 http://www.ebi.ac.uk/pdbsum/5DS5 PDBsum 5DS6 http://www.ebi.ac.uk/pdbsum/5DS6 PSORT swissprot:CAS2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CAS2_ECOLI PSORT-B swissprot:CAS2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CAS2_ECOLI PSORT2 swissprot:CAS2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CAS2_ECOLI Pfam PF09707 http://pfam.xfam.org/family/PF09707 Phobius swissprot:CAS2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CAS2_ECOLI ProteinModelPortal P45956 http://www.proteinmodelportal.org/query/uniprot/P45956 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19429622 http://www.ncbi.nlm.nih.gov/pubmed/19429622 PubMed 20132443 http://www.ncbi.nlm.nih.gov/pubmed/20132443 PubMed 21255106 http://www.ncbi.nlm.nih.gov/pubmed/21255106 PubMed 24793649 http://www.ncbi.nlm.nih.gov/pubmed/24793649 PubMed 24920831 http://www.ncbi.nlm.nih.gov/pubmed/24920831 PubMed 25707795 http://www.ncbi.nlm.nih.gov/pubmed/25707795 PubMed 26478180 http://www.ncbi.nlm.nih.gov/pubmed/26478180 PubMed 26503043 http://www.ncbi.nlm.nih.gov/pubmed/26503043 PubMed 2656660 http://www.ncbi.nlm.nih.gov/pubmed/2656660 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417234 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417234 RefSeq WP_001381369 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001381369 SMR P45956 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45956 STRING 511145.b2754 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2754&targetmode=cogs TIGRFAMs TIGR01873 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01873 UniProtKB CAS2_ECOLI http://www.uniprot.org/uniprot/CAS2_ECOLI UniProtKB-AC P45956 http://www.uniprot.org/uniprot/P45956 charge swissprot:CAS2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CAS2_ECOLI eggNOG ENOG4105PWE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105PWE eggNOG ENOG4111VHR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111VHR epestfind swissprot:CAS2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CAS2_ECOLI garnier swissprot:CAS2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CAS2_ECOLI helixturnhelix swissprot:CAS2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CAS2_ECOLI hmoment swissprot:CAS2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CAS2_ECOLI iep swissprot:CAS2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CAS2_ECOLI inforesidue swissprot:CAS2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CAS2_ECOLI octanol swissprot:CAS2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CAS2_ECOLI pepcoil swissprot:CAS2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CAS2_ECOLI pepdigest swissprot:CAS2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CAS2_ECOLI pepinfo swissprot:CAS2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CAS2_ECOLI pepnet swissprot:CAS2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CAS2_ECOLI pepstats swissprot:CAS2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CAS2_ECOLI pepwheel swissprot:CAS2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CAS2_ECOLI pepwindow swissprot:CAS2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CAS2_ECOLI sigcleave swissprot:CAS2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CAS2_ECOLI ## Database ID URL or Descriptions # CDD cd00392 Ribosomal_L13 # EcoGene EG10874 rplM # FUNCTION RL13_ECOLI This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. {ECO 0000269|PubMed 3298242}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0022625 cytosolic large ribosomal subunit; IDA:EcoCyc. # GO_function GO:0003729 mRNA binding; IBA:GO_Central. # GO_function GO:0003735 structural constituent of ribosome; IBA:GO_Central. # GO_function GO:0008270 zinc ion binding; IDA:EcoliWiki. # GO_process GO:0006412 translation; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003729 mRNA binding # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006412 translation # Gene3D 3.90.1180.10 -; 1. # HAMAP MF_01366 Ribosomal_L13 # IntAct P0AA10 112 # InterPro IPR005822 Ribosomal_L13 # InterPro IPR005823 Ribosomal_L13_bac-type # InterPro IPR023563 Ribosomal_L13_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 M00179 Ribosome, archaea # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=16018.0; Method=MALDI; Range=1-142; Evidence={ECO:0000269|PubMed 10094780}; # Organism RL13_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11545 PTHR11545 # PATRIC 32121888 VBIEscCol129921_3328 # PDB 1ML5 EM; 14.00 A; m=1-142 # PDB 2J28 EM; 8.00 A; J=1-140 # PDB 2RDO EM; 9.10 A; J=1-142 # PDB 3BBX EM; 10.00 A; J=1-142 # PDB 3IY9 EM; 14.10 A; J=1-140 # PDB 3J5L EM; 6.60 A; J=1-142 # PDB 3J7Z EM; 3.90 A; J=1-142 # PDB 3J8G EM; 5.00 A; J=1-142 # PDB 3J9Y EM; 3.90 A; J=1-142 # PDB 3J9Z EM; 3.60 A; LF=1-142 # PDB 3JA1 EM; 3.60 A; LL=1-142 # PDB 3JBU EM; 3.64 A; j=1-142 # PDB 3JBV EM; 3.32 A; j=1-142 # PDB 3JCD EM; 3.70 A; J=1-142 # PDB 3JCE EM; 3.20 A; J=1-142 # PDB 3JCJ EM; 3.70 A; I=1-142 # PDB 3JCN EM; 4.60 A; J=1-142 # PDB 4CSU EM; 5.50 A; J=1-142 # PDB 4U1U X-ray; 2.95 A; BJ/DJ=1-142 # PDB 4U1V X-ray; 3.00 A; BJ/DJ=1-142 # PDB 4U20 X-ray; 2.90 A; BJ/DJ=1-142 # PDB 4U24 X-ray; 2.90 A; BJ/DJ=1-142 # PDB 4U25 X-ray; 2.90 A; BJ/DJ=1-142 # PDB 4U26 X-ray; 2.80 A; BJ/DJ=1-142 # PDB 4U27 X-ray; 2.80 A; BJ/DJ=1-142 # PDB 4UY8 EM; 3.80 A; J=1-142 # PDB 4V47 EM; 12.30 A; AH=1-142 # PDB 4V48 EM; 11.50 A; AH=1-142 # PDB 4V4H X-ray; 3.46 A; BJ/DJ=1-142 # PDB 4V4Q X-ray; 3.46 A; BJ/DJ=1-142 # PDB 4V4V EM; 15.00 A; BH=1-142 # PDB 4V4W EM; 15.00 A; BH=1-142 # PDB 4V50 X-ray; 3.22 A; BJ/DJ=1-142 # PDB 4V52 X-ray; 3.21 A; BJ/DJ=1-142 # PDB 4V53 X-ray; 3.54 A; BJ/DJ=1-142 # PDB 4V54 X-ray; 3.30 A; BJ/DJ=1-142 # PDB 4V55 X-ray; 4.00 A; BJ/DJ=1-142 # PDB 4V56 X-ray; 3.93 A; BJ/DJ=1-142 # PDB 4V57 X-ray; 3.50 A; BJ/DJ=1-142 # PDB 4V5B X-ray; 3.74 A; AJ/CJ=1-142 # PDB 4V5H EM; 5.80 A; BJ=1-142 # PDB 4V5Y X-ray; 4.45 A; BJ/DJ=1-142 # PDB 4V64 X-ray; 3.50 A; BJ/DJ=1-142 # PDB 4V65 EM; 9.00 A; B6=1-140 # PDB 4V66 EM; 9.00 A; B6=1-140 # PDB 4V69 EM; 6.70 A; BJ=1-142 # PDB 4V6C X-ray; 3.19 A; BJ/DJ=1-142 # PDB 4V6D X-ray; 3.81 A; BJ/DJ=1-142 # PDB 4V6E X-ray; 3.71 A; BJ/DJ=1-142 # PDB 4V6K EM; 8.25 A; AK=1-142 # PDB 4V6L EM; 13.20 A; BK=1-142 # PDB 4V6M EM; 7.10 A; BJ=1-142 # PDB 4V6N EM; 12.10 A; AL=1-142 # PDB 4V6O EM; 14.70 A; BL=1-142 # PDB 4V6P EM; 13.50 A; BL=1-142 # PDB 4V6Q EM; 11.50 A; BL=1-142 # PDB 4V6R EM; 11.50 A; BL=1-142 # PDB 4V6S EM; 13.10 A; AL=1-142 # PDB 4V6T EM; 8.30 A; BJ=1-142 # PDB 4V6V EM; 9.80 A; BN=1-142 # PDB 4V6Y EM; 12.00 A; BJ=1-142 # PDB 4V6Z EM; 12.00 A; BJ=1-142 # PDB 4V70 EM; 17.00 A; BJ=1-142 # PDB 4V71 EM; 20.00 A; BJ=1-142 # PDB 4V72 EM; 13.00 A; BJ=1-142 # PDB 4V73 EM; 15.00 A; BJ=1-142 # PDB 4V74 EM; 17.00 A; BJ=1-142 # PDB 4V75 EM; 12.00 A; BJ=1-142 # PDB 4V76 EM; 17.00 A; BJ=1-142 # PDB 4V77 EM; 17.00 A; BJ=1-142 # PDB 4V78 EM; 20.00 A; BJ=1-142 # PDB 4V79 EM; 15.00 A; BJ=1-142 # PDB 4V7A EM; 9.00 A; BJ=1-142 # PDB 4V7B EM; 6.80 A; BJ=1-142 # PDB 4V7C EM; 7.60 A; BL=1-142 # PDB 4V7D EM; 7.60 A; AM=1-142 # PDB 4V7I EM; 9.60 A; AJ=1-142 # PDB 4V7S X-ray; 3.25 A; BJ/DJ=1-142 # PDB 4V7T X-ray; 3.19 A; BJ/DJ=1-142 # PDB 4V7U X-ray; 3.10 A; BJ/DJ=1-142 # PDB 4V7V X-ray; 3.29 A; BJ/DJ=1-142 # PDB 4V85 X-ray; 3.20 A; N=1-142 # PDB 4V89 X-ray; 3.70 A; BN=1-142 # PDB 4V9C X-ray; 3.30 A; BJ/DJ=1-142 # PDB 4V9D X-ray; 3.00 A; CJ/DJ=1-142 # PDB 4V9O X-ray; 2.90 A; AJ/CJ/EJ/GJ=1-142 # PDB 4V9P X-ray; 2.90 A; AJ/CJ/EJ/GJ=1-142 # PDB 4WF1 X-ray; 3.09 A; BJ/DJ=1-142 # PDB 4WOI X-ray; 3.00 A; BJ/CJ=1-142 # PDB 4WWW X-ray; 3.10 A; RJ/YJ=1-142 # PDB 4YBB X-ray; 2.10 A; CK/DK=1-142 # PDB 5ADY EM; 4.50 A; J=1-142 # PDB 5AFI EM; 2.90 A; J=1-142 # PDB 5AKA EM; 5.70 A; J=1-142 # PDB 5GAD EM; 3.70 A; K=1-142 # PDB 5GAE EM; 3.33 A; K=1-142 # PDB 5GAF EM; 4.30 A; K=1-142 # PDB 5GAG EM; 3.80 A; K=1-142 # PDB 5GAH EM; 3.80 A; K=1-142 # PDB 5IQR EM; 3.00 A; J=1-142 # PDB 5IT8 X-ray; 3.12 A; CK/DK=1-142 # PDB 5J5B X-ray; 2.80 A; CK/DK=1-142 # PDB 5J7L X-ray; 3.00 A; CK/DK=1-142 # PDB 5J88 X-ray; 3.32 A; CK/DK=1-142 # PDB 5J8A X-ray; 3.10 A; CK/DK=1-142 # PDB 5J91 X-ray; 2.96 A; CK/DK=1-142 # PDB 5JC9 X-ray; 3.03 A; CK/DK=1-142 # PDB 5JTE EM; 3.60 A; BJ=1-142 # PDB 5JU8 EM; 3.60 A; BJ=1-142 # PDB 5KCR EM; 3.60 A; 1N=1-142 # PDB 5KCS EM; 3.90 A; 1N=1-142 # PDB 5KPS EM; 3.90 A; J=1-142 # PDB 5KPV EM; 4.10 A; I=1-142 # PDB 5KPW EM; 3.90 A; I=1-142 # PDB 5KPX EM; 3.90 A; I=1-142 # PDB 5L3P EM; 3.70 A; N=1-142 # PIR A02787 R5EC13 # PIRSF PIRSF002181 Ribosomal_L13 # PROSITE PS00783 RIBOSOMAL_L13 # Pfam PF00572 Ribosomal_L13 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 50S ribosomal protein L13 {ECO:0000255|HAMAP-Rule MF_01366} # RefSeq NP_417698 NC_000913.3 # RefSeq WP_000847559 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein L13P family. {ECO:0000255|HAMAP-Rule MF_01366}. # SUBUNIT RL13_ECOLI Part of the 50S ribosomal subunit. # SUPFAM SSF52161 SSF52161 # TIGRFAMs TIGR01066 rplM_bact # eggNOG COG0102 LUCA BLAST swissprot:RL13_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RL13_ECOLI BioCyc ECOL316407:JW3200-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3200-MONOMER BioCyc EcoCyc:EG10874-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10874-MONOMER BioCyc MetaCyc:EG10874-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10874-MONOMER COG COG0102 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0102 DIP DIP-47837N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47837N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1007/BF00383007 http://dx.doi.org/10.1007/BF00383007 DOI 10.1016/0014-5793(78)80425-6 http://dx.doi.org/10.1016/0014-5793(78)80425-6 DOI 10.1016/S0092-8674(03)00427-6 http://dx.doi.org/10.1016/S0092-8674(03)00427-6 DOI 10.1016/j.celrep.2014.09.011 http://dx.doi.org/10.1016/j.celrep.2014.09.011 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pbio.1001866 http://dx.doi.org/10.1371/journal.pbio.1001866 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X02130 http://www.ebi.ac.uk/ena/data/view/X02130 EchoBASE EB0867 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0867 EcoGene EG10874 http://www.ecogene.org/geneInfo.php?eg_id=EG10874 EnsemblBacteria AAC76263 http://www.ensemblgenomes.org/id/AAC76263 EnsemblBacteria AAC76263 http://www.ensemblgenomes.org/id/AAC76263 EnsemblBacteria BAE77274 http://www.ensemblgenomes.org/id/BAE77274 EnsemblBacteria BAE77274 http://www.ensemblgenomes.org/id/BAE77274 EnsemblBacteria BAE77274 http://www.ensemblgenomes.org/id/BAE77274 EnsemblBacteria b3231 http://www.ensemblgenomes.org/id/b3231 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0022625 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022625 GO_function GO:0003729 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003729 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003729 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003729 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 Gene3D 3.90.1180.10 http://www.cathdb.info/version/latest/superfamily/3.90.1180.10 GeneID 947828 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947828 HAMAP MF_01366 http://hamap.expasy.org/unirule/MF_01366 HOGENOM HOG000225286 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000225286&db=HOGENOM6 InParanoid P0AA10 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AA10 IntAct P0AA10 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AA10* InterPro IPR005822 http://www.ebi.ac.uk/interpro/entry/IPR005822 InterPro IPR005823 http://www.ebi.ac.uk/interpro/entry/IPR005823 InterPro IPR023563 http://www.ebi.ac.uk/interpro/entry/IPR023563 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW3200 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3200 KEGG_Gene eco:b3231 http://www.genome.jp/dbget-bin/www_bget?eco:b3231 KEGG_Orthology KO:K02871 http://www.genome.jp/dbget-bin/www_bget?KO:K02871 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 MINT MINT-1269598 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1269598 OMA MLPRNAL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MLPRNAL PANTHER PTHR11545 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11545 PDB 1ML5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ML5 PDB 2J28 http://www.ebi.ac.uk/pdbe-srv/view/entry/2J28 PDB 2RDO http://www.ebi.ac.uk/pdbe-srv/view/entry/2RDO PDB 3BBX http://www.ebi.ac.uk/pdbe-srv/view/entry/3BBX PDB 3IY9 http://www.ebi.ac.uk/pdbe-srv/view/entry/3IY9 PDB 3J5L http://www.ebi.ac.uk/pdbe-srv/view/entry/3J5L PDB 3J7Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J7Z PDB 3J8G http://www.ebi.ac.uk/pdbe-srv/view/entry/3J8G PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 4CSU http://www.ebi.ac.uk/pdbe-srv/view/entry/4CSU PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4UY8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4UY8 PDB 4V47 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V47 PDB 4V48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V48 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5ADY http://www.ebi.ac.uk/pdbe-srv/view/entry/5ADY PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5AKA http://www.ebi.ac.uk/pdbe-srv/view/entry/5AKA PDB 5GAD http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAD PDB 5GAE http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAE PDB 5GAF http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAF PDB 5GAG http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAG PDB 5GAH http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAH PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 1ML5 http://www.ebi.ac.uk/pdbsum/1ML5 PDBsum 2J28 http://www.ebi.ac.uk/pdbsum/2J28 PDBsum 2RDO http://www.ebi.ac.uk/pdbsum/2RDO PDBsum 3BBX http://www.ebi.ac.uk/pdbsum/3BBX PDBsum 3IY9 http://www.ebi.ac.uk/pdbsum/3IY9 PDBsum 3J5L http://www.ebi.ac.uk/pdbsum/3J5L PDBsum 3J7Z http://www.ebi.ac.uk/pdbsum/3J7Z PDBsum 3J8G http://www.ebi.ac.uk/pdbsum/3J8G PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 4CSU http://www.ebi.ac.uk/pdbsum/4CSU PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4UY8 http://www.ebi.ac.uk/pdbsum/4UY8 PDBsum 4V47 http://www.ebi.ac.uk/pdbsum/4V47 PDBsum 4V48 http://www.ebi.ac.uk/pdbsum/4V48 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5ADY http://www.ebi.ac.uk/pdbsum/5ADY PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5AKA http://www.ebi.ac.uk/pdbsum/5AKA PDBsum 5GAD http://www.ebi.ac.uk/pdbsum/5GAD PDBsum 5GAE http://www.ebi.ac.uk/pdbsum/5GAE PDBsum 5GAF http://www.ebi.ac.uk/pdbsum/5GAF PDBsum 5GAG http://www.ebi.ac.uk/pdbsum/5GAG PDBsum 5GAH http://www.ebi.ac.uk/pdbsum/5GAH PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PROSITE PS00783 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00783 PSORT swissprot:RL13_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RL13_ECOLI PSORT-B swissprot:RL13_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RL13_ECOLI PSORT2 swissprot:RL13_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RL13_ECOLI Pfam PF00572 http://pfam.xfam.org/family/PF00572 Phobius swissprot:RL13_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RL13_ECOLI PhylomeDB P0AA10 http://phylomedb.org/?seqid=P0AA10 ProteinModelPortal P0AA10 http://www.proteinmodelportal.org/query/uniprot/P0AA10 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 12809609 http://www.ncbi.nlm.nih.gov/pubmed/12809609 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 24844575 http://www.ncbi.nlm.nih.gov/pubmed/24844575 PubMed 25310980 http://www.ncbi.nlm.nih.gov/pubmed/25310980 PubMed 3298242 http://www.ncbi.nlm.nih.gov/pubmed/3298242 PubMed 365580 http://www.ncbi.nlm.nih.gov/pubmed/365580 PubMed 3884974 http://www.ncbi.nlm.nih.gov/pubmed/3884974 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_417698 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417698 RefSeq WP_000847559 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000847559 SMR P0AA10 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AA10 STRING 511145.b3231 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3231&targetmode=cogs STRING COG0102 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0102&targetmode=cogs SUPFAM SSF52161 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52161 TIGRFAMs TIGR01066 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01066 UniProtKB RL13_ECOLI http://www.uniprot.org/uniprot/RL13_ECOLI UniProtKB-AC P0AA10 http://www.uniprot.org/uniprot/P0AA10 charge swissprot:RL13_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RL13_ECOLI eggNOG COG0102 http://eggnogapi.embl.de/nog_data/html/tree/COG0102 epestfind swissprot:RL13_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RL13_ECOLI garnier swissprot:RL13_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RL13_ECOLI helixturnhelix swissprot:RL13_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RL13_ECOLI hmoment swissprot:RL13_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RL13_ECOLI iep swissprot:RL13_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RL13_ECOLI inforesidue swissprot:RL13_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RL13_ECOLI octanol swissprot:RL13_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RL13_ECOLI pepcoil swissprot:RL13_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RL13_ECOLI pepdigest swissprot:RL13_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RL13_ECOLI pepinfo swissprot:RL13_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RL13_ECOLI pepnet swissprot:RL13_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RL13_ECOLI pepstats swissprot:RL13_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RL13_ECOLI pepwheel swissprot:RL13_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RL13_ECOLI pepwindow swissprot:RL13_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RL13_ECOLI sigcleave swissprot:RL13_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RL13_ECOLI ## Database ID URL or Descriptions # AltName MCP4_ECOLI Dipeptide chemoreceptor protein # BioGrid 4262072 163 # CDD cd00181 Tar_Tsr_LBD # CDD cd06225 HAMP # EcoGene EG10987 tap # FUNCTION MCP4_ECOLI Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. Attractants increase the level of methylation while repellents decrease the level of methylation, the methyl groups are added by the methyltransferase CheR and removed by the methylesterase CheB. # FUNCTION MCP4_ECOLI Mediates taxis toward dipeptides via an interaction with the periplasmic dipeptide-binding protein. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0004871 signal transducer activity; IMP:EcoCyc. # GO_function GO:0004888 transmembrane signaling receptor activity; IMP:EcoCyc. # GO_process GO:0006935 chemotaxis; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0004871 signal transducer activity # GOslim_process GO:0040011 locomotion # Gene3D 1.20.120.30 -; 1. # IntAct P07018 2 # InterPro IPR003122 Chemotax_Me-accpt_rcpt_lig-bd # InterPro IPR003660 HAMP_dom # InterPro IPR004089 MCPsignal_dom # InterPro IPR004090 Chemotax_Me-accpt_rcpt # InterPro IPR004091 Chemotax_Me-accpt_rcpt_Me-site # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Pathway ko02020 Two-component system # KEGG_Pathway ko02030 Bacterial chemotaxis # Organism MCP4_ECOLI Escherichia coli (strain K12) # PATRIC 32119097 VBIEscCol129921_1966 # PIR E64951 QRECM2 # PRINTS PR00260 CHEMTRNSDUCR # PROSITE PS00538 CHEMOTAXIS_TRANSDUC_1 # PROSITE PS50111 CHEMOTAXIS_TRANSDUC_2 # PROSITE PS50885 HAMP # Pfam PF00015 MCPsignal # Pfam PF00672 HAMP # Pfam PF02203 TarH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MCP4_ECOLI Methyl-accepting chemotaxis protein IV # RefSeq NP_416399 NC_000913.3 # RefSeq WP_000483239 NZ_LN832404.1 # SIMILARITY Contains 1 HAMP domain. {ECO:0000255|PROSITE- ProRule PRU00102}. # SIMILARITY Contains 1 methyl-accepting transducer domain. {ECO:0000255|PROSITE-ProRule PRU00284}. # SMART SM00283 MA # SMART SM00304 HAMP # SMART SM00319 TarH # SUBCELLULAR LOCATION MCP4_ECOLI Cell inner membrane {ECO 0000269|PubMed 22380631}; Multi-pass membrane protein {ECO 0000269|PubMed 22380631}. Note=Found predominantly at cell poles. # SUPFAM SSF47170 SSF47170 # eggNOG COG0840 LUCA # eggNOG ENOG4105C8Q Bacteria BLAST swissprot:MCP4_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MCP4_ECOLI BioCyc ECOL316407:JW1874-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1874-MONOMER BioCyc EcoCyc:TAP-MONOMER http://biocyc.org/getid?id=EcoCyc:TAP-MONOMER COG COG0840 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0840 DIP DIP-10955N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10955N DOI 10.1016/0092-8674(83)90442-7 http://dx.doi.org/10.1016/0092-8674(83)90442-7 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1111/j.1365-2958.2012.08021.x http://dx.doi.org/10.1111/j.1365-2958.2012.08021.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01705 http://www.ebi.ac.uk/ena/data/view/J01705 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0980 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0980 EcoGene EG10987 http://www.ecogene.org/geneInfo.php?eg_id=EG10987 EnsemblBacteria AAC74955 http://www.ensemblgenomes.org/id/AAC74955 EnsemblBacteria AAC74955 http://www.ensemblgenomes.org/id/AAC74955 EnsemblBacteria BAA15701 http://www.ensemblgenomes.org/id/BAA15701 EnsemblBacteria BAA15701 http://www.ensemblgenomes.org/id/BAA15701 EnsemblBacteria BAA15701 http://www.ensemblgenomes.org/id/BAA15701 EnsemblBacteria b1885 http://www.ensemblgenomes.org/id/b1885 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GO_function GO:0004888 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004888 GO_process GO:0006935 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006935 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_process GO:0040011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011 Gene3D 1.20.120.30 http://www.cathdb.info/version/latest/superfamily/1.20.120.30 GeneID 946397 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946397 HOGENOM HOG000148074 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000148074&db=HOGENOM6 InParanoid P07018 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P07018 IntAct P07018 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P07018* InterPro IPR003122 http://www.ebi.ac.uk/interpro/entry/IPR003122 InterPro IPR003660 http://www.ebi.ac.uk/interpro/entry/IPR003660 InterPro IPR004089 http://www.ebi.ac.uk/interpro/entry/IPR004089 InterPro IPR004090 http://www.ebi.ac.uk/interpro/entry/IPR004090 InterPro IPR004091 http://www.ebi.ac.uk/interpro/entry/IPR004091 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW1874 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1874 KEGG_Gene eco:b1885 http://www.genome.jp/dbget-bin/www_bget?eco:b1885 KEGG_Orthology KO:K05877 http://www.genome.jp/dbget-bin/www_bget?KO:K05877 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 KEGG_Pathway ko02030 http://www.genome.jp/kegg-bin/show_pathway?ko02030 MINT MINT-1309514 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1309514 OMA YQISTLV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YQISTLV PRINTS PR00260 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00260 PROSITE PS00538 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00538 PROSITE PS50111 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50111 PROSITE PS50885 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50885 PSORT swissprot:MCP4_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MCP4_ECOLI PSORT-B swissprot:MCP4_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MCP4_ECOLI PSORT2 swissprot:MCP4_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MCP4_ECOLI Pfam PF00015 http://pfam.xfam.org/family/PF00015 Pfam PF00672 http://pfam.xfam.org/family/PF00672 Pfam PF02203 http://pfam.xfam.org/family/PF02203 Phobius swissprot:MCP4_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MCP4_ECOLI PhylomeDB P07018 http://phylomedb.org/?seqid=P07018 ProteinModelPortal P07018 http://www.proteinmodelportal.org/query/uniprot/P07018 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22380631 http://www.ncbi.nlm.nih.gov/pubmed/22380631 PubMed 6305515 http://www.ncbi.nlm.nih.gov/pubmed/6305515 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416399 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416399 RefSeq WP_000483239 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000483239 SMART SM00283 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00283 SMART SM00304 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00304 SMART SM00319 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00319 SMR P07018 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P07018 STRING 511145.b1885 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1885&targetmode=cogs STRING COG0840 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0840&targetmode=cogs SUPFAM SSF47170 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47170 UniProtKB MCP4_ECOLI http://www.uniprot.org/uniprot/MCP4_ECOLI UniProtKB-AC P07018 http://www.uniprot.org/uniprot/P07018 charge swissprot:MCP4_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MCP4_ECOLI eggNOG COG0840 http://eggnogapi.embl.de/nog_data/html/tree/COG0840 eggNOG ENOG4105C8Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C8Q epestfind swissprot:MCP4_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MCP4_ECOLI garnier swissprot:MCP4_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MCP4_ECOLI helixturnhelix swissprot:MCP4_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MCP4_ECOLI hmoment swissprot:MCP4_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MCP4_ECOLI iep swissprot:MCP4_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MCP4_ECOLI inforesidue swissprot:MCP4_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MCP4_ECOLI octanol swissprot:MCP4_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MCP4_ECOLI pepcoil swissprot:MCP4_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MCP4_ECOLI pepdigest swissprot:MCP4_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MCP4_ECOLI pepinfo swissprot:MCP4_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MCP4_ECOLI pepnet swissprot:MCP4_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MCP4_ECOLI pepstats swissprot:MCP4_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MCP4_ECOLI pepwheel swissprot:MCP4_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MCP4_ECOLI pepwindow swissprot:MCP4_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MCP4_ECOLI sigcleave swissprot:MCP4_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MCP4_ECOLI ## Database ID URL or Descriptions # BioGrid 4260304 400 # EcoGene EG13992 cedA # FUNCTION CEDA_ECOLI Activates the cell division inhibited by chromosomal DNA over-replication. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-HAMAP. # GO_process GO:0007049 cell cycle; IEA:UniProtKB-KW. # GO_process GO:0051301 cell division; IEA:UniProtKB-HAMAP. # GO_process GO:0051302 regulation of cell division; IGI:EcoCyc. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0007049 cell cycle # GOslim_process GO:0008150 biological_process # GOslim_process GO:0051301 cell division # HAMAP MF_01580 CedA # IntAct P0AE60 14 # InterPro IPR019666 Cell_div_activator_CedA # MISCELLANEOUS CEDA_ECOLI In vitro, binds double-stranded DNA, but not single-stranded DNA. # Organism CEDA_ECOLI Escherichia coli (strain K12) # PATRIC 32118769 VBIEscCol129921_1802 # PDB 2BN8 NMR; -; A=1-80 # PDB 2D35 NMR; -; A=19-80 # PIR C64932 C64932 # Pfam PF10729 CedA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CEDA_ECOLI Cell division activator CedA # RefSeq NP_416245 NC_000913.3 # RefSeq WP_001295480 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAE76513.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the CedA family. {ECO 0000305}. # eggNOG ENOG4105R8J Bacteria # eggNOG ENOG4111YYN LUCA BLAST swissprot:CEDA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CEDA_ECOLI BioCyc ECOL316407:JW1720-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1720-MONOMER BioCyc EcoCyc:G6936-MONOMER http://biocyc.org/getid?id=EcoCyc:G6936-MONOMER DIP DIP-47928N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47928N DOI 10.1021/bi0500269 http://dx.doi.org/10.1021/bi0500269 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1997.5941967.x http://dx.doi.org/10.1046/j.1365-2958.1997.5941967.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3748 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3748 EcoGene EG13992 http://www.ecogene.org/geneInfo.php?eg_id=EG13992 EnsemblBacteria AAC74801 http://www.ensemblgenomes.org/id/AAC74801 EnsemblBacteria AAC74801 http://www.ensemblgenomes.org/id/AAC74801 EnsemblBacteria BAE76513 http://www.ensemblgenomes.org/id/BAE76513 EnsemblBacteria BAE76513 http://www.ensemblgenomes.org/id/BAE76513 EnsemblBacteria BAE76513 http://www.ensemblgenomes.org/id/BAE76513 EnsemblBacteria b1731 http://www.ensemblgenomes.org/id/b1731 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GO_process GO:0051302 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051302 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GeneID 946235 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946235 HAMAP MF_01580 http://hamap.expasy.org/unirule/MF_01580 HOGENOM HOG000267901 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267901&db=HOGENOM6 IntAct P0AE60 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AE60* InterPro IPR019666 http://www.ebi.ac.uk/interpro/entry/IPR019666 KEGG_Gene ecj:JW1720 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1720 KEGG_Gene eco:b1731 http://www.genome.jp/dbget-bin/www_bget?eco:b1731 KEGG_Orthology KO:K15722 http://www.genome.jp/dbget-bin/www_bget?KO:K15722 OMA QNRPVIS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QNRPVIS PDB 2BN8 http://www.ebi.ac.uk/pdbe-srv/view/entry/2BN8 PDB 2D35 http://www.ebi.ac.uk/pdbe-srv/view/entry/2D35 PDBsum 2BN8 http://www.ebi.ac.uk/pdbsum/2BN8 PDBsum 2D35 http://www.ebi.ac.uk/pdbsum/2D35 PSORT swissprot:CEDA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CEDA_ECOLI PSORT-B swissprot:CEDA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CEDA_ECOLI PSORT2 swissprot:CEDA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CEDA_ECOLI Pfam PF10729 http://pfam.xfam.org/family/PF10729 Phobius swissprot:CEDA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CEDA_ECOLI ProteinModelPortal P0AE60 http://www.proteinmodelportal.org/query/uniprot/P0AE60 PubMed 15865419 http://www.ncbi.nlm.nih.gov/pubmed/15865419 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9427399 http://www.ncbi.nlm.nih.gov/pubmed/9427399 RefSeq NP_416245 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416245 RefSeq WP_001295480 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295480 SMR P0AE60 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AE60 STRING 511145.b1731 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1731&targetmode=cogs UniProtKB CEDA_ECOLI http://www.uniprot.org/uniprot/CEDA_ECOLI UniProtKB-AC P0AE60 http://www.uniprot.org/uniprot/P0AE60 charge swissprot:CEDA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CEDA_ECOLI eggNOG ENOG4105R8J http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105R8J eggNOG ENOG4111YYN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111YYN epestfind swissprot:CEDA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CEDA_ECOLI garnier swissprot:CEDA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CEDA_ECOLI helixturnhelix swissprot:CEDA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CEDA_ECOLI hmoment swissprot:CEDA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CEDA_ECOLI iep swissprot:CEDA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CEDA_ECOLI inforesidue swissprot:CEDA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CEDA_ECOLI octanol swissprot:CEDA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CEDA_ECOLI pepcoil swissprot:CEDA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CEDA_ECOLI pepdigest swissprot:CEDA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CEDA_ECOLI pepinfo swissprot:CEDA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CEDA_ECOLI pepnet swissprot:CEDA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CEDA_ECOLI pepstats swissprot:CEDA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CEDA_ECOLI pepwheel swissprot:CEDA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CEDA_ECOLI pepwindow swissprot:CEDA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CEDA_ECOLI sigcleave swissprot:CEDA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CEDA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259564 52 # EcoGene EG12839 yrdB # Gene3D 3.30.160.140 -; 1. # InterPro IPR009962 DUF1488 # Organism YRDB_ECOLI Escherichia coli (strain K12) # PATRIC 32121994 VBIEscCol129921_3374 # PIR C65120 C65120 # Pfam PF07369 DUF1488 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YRDB_ECOLI Uncharacterized protein YrdB # RefSeq NP_417739 NC_000913.3 # RefSeq WP_001070563 NZ_LN832404.1 # SUPFAM SSF160272 SSF160272 # eggNOG ENOG4105SG3 Bacteria # eggNOG ENOG4111VAC LUCA BLAST swissprot:YRDB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YRDB_ECOLI BioCyc ECOL316407:JW3241-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3241-MONOMER BioCyc EcoCyc:G7697-MONOMER http://biocyc.org/getid?id=EcoCyc:G7697-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2688 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2688 EcoGene EG12839 http://www.ecogene.org/geneInfo.php?eg_id=EG12839 EnsemblBacteria AAC76305 http://www.ensemblgenomes.org/id/AAC76305 EnsemblBacteria AAC76305 http://www.ensemblgenomes.org/id/AAC76305 EnsemblBacteria BAE78011 http://www.ensemblgenomes.org/id/BAE78011 EnsemblBacteria BAE78011 http://www.ensemblgenomes.org/id/BAE78011 EnsemblBacteria BAE78011 http://www.ensemblgenomes.org/id/BAE78011 EnsemblBacteria b3280 http://www.ensemblgenomes.org/id/b3280 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.30.160.140 http://www.cathdb.info/version/latest/superfamily/3.30.160.140 GeneID 947774 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947774 HOGENOM HOG000270089 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000270089&db=HOGENOM6 InterPro IPR009962 http://www.ebi.ac.uk/interpro/entry/IPR009962 KEGG_Gene ecj:JW3241 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3241 KEGG_Gene eco:b3280 http://www.genome.jp/dbget-bin/www_bget?eco:b3280 OMA MNQSIQF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MNQSIQF PSORT swissprot:YRDB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YRDB_ECOLI PSORT-B swissprot:YRDB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YRDB_ECOLI PSORT2 swissprot:YRDB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YRDB_ECOLI Pfam PF07369 http://pfam.xfam.org/family/PF07369 Phobius swissprot:YRDB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YRDB_ECOLI ProteinModelPortal P45795 http://www.proteinmodelportal.org/query/uniprot/P45795 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417739 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417739 RefSeq WP_001070563 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001070563 SMR P45795 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45795 STRING 511145.b3280 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3280&targetmode=cogs SUPFAM SSF160272 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF160272 UniProtKB YRDB_ECOLI http://www.uniprot.org/uniprot/YRDB_ECOLI UniProtKB-AC P45795 http://www.uniprot.org/uniprot/P45795 charge swissprot:YRDB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YRDB_ECOLI eggNOG ENOG4105SG3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105SG3 eggNOG ENOG4111VAC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111VAC epestfind swissprot:YRDB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YRDB_ECOLI garnier swissprot:YRDB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YRDB_ECOLI helixturnhelix swissprot:YRDB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YRDB_ECOLI hmoment swissprot:YRDB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YRDB_ECOLI iep swissprot:YRDB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YRDB_ECOLI inforesidue swissprot:YRDB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YRDB_ECOLI octanol swissprot:YRDB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YRDB_ECOLI pepcoil swissprot:YRDB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YRDB_ECOLI pepdigest swissprot:YRDB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YRDB_ECOLI pepinfo swissprot:YRDB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YRDB_ECOLI pepnet swissprot:YRDB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YRDB_ECOLI pepstats swissprot:YRDB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YRDB_ECOLI pepwheel swissprot:YRDB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YRDB_ECOLI pepwindow swissprot:YRDB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YRDB_ECOLI sigcleave swissprot:YRDB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YRDB_ECOLI ## Database ID URL or Descriptions # AltName D-tartrate dehydratase {ECO:0000303|PubMed 23405168} # AltName Fumarase B {ECO:0000303|PubMed 23405168} # BIOPHYSICOCHEMICAL PROPERTIES FUMB_ECOLI Kinetic parameters KM=300 uM for (S)-malate {ECO 0000269|PubMed 23405168}; KM=320 uM for fumarate {ECO 0000269|PubMed 23405168}; KM=800 uM for D-tartrate {ECO 0000269|PubMed 23405168}; Vmax=490 umol/min/mg enzyme for (S)-malate dehydration {ECO 0000269|PubMed 23405168}; Vmax=1430 umol/min/mg enzyme for fumarate hydration {ECO 0000269|PubMed 23405168}; Vmax=9.2 umol/min/mg enzyme for D-tartrate dehydration {ECO 0000269|PubMed 23405168}; # BioGrid 4262150 8 # CATALYTIC ACTIVITY (S)-malate = fumarate + H(2)O. {ECO:0000269|PubMed 23405168}. # CATALYTIC ACTIVITY (S,S)-tartrate = oxaloacetate + H(2)O. {ECO:0000269|PubMed 23405168}. # COFACTOR FUMB_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000269|PubMed 23405168}; Note=Binds 1 [4Fe-4S] cluster. {ECO 0000269|PubMed 23405168}; # DISRUPTION PHENOTYPE Disruption of this gene seriously impairs growth under anaerobic conditions on D-tartrate when glycerol is supplied as an electron donor (D-tartrate fermentation). Cells lacking this gene also lose most (about 79%) of D-tartrate dehydratase activity. {ECO:0000269|PubMed 17643228}. # EcoGene EG10357 fumB # FUNCTION FUMB_ECOLI Catalyzes the reversible hydration of fumarate to (S)- malate. Functions in the generation of fumarate for use as an anaerobic electron acceptor. To a lesser extent, also displays D- tartrate dehydratase activity, but is not able to convert (R)- malate, L-tartrate or meso-tartrate. Is required for anaerobic growth on D-tartrate. {ECO 0000269|PubMed 17643228, ECO 0000269|PubMed 23405168, ECO 0000269|PubMed 3282546, ECO 0000269|Ref.6}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0004333 fumarate hydratase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0047808 D(-)-tartrate dehydratase activity; IDA:EcoCyc. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IDA:EcoCyc. # GO_process GO:0006099 tricarboxylic acid cycle; IGI:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0044010 single-species biofilm formation; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.130.10 -; 1. # INDUCTION Is mainly expressed during anaerobic growth. Is under the control of the Fnr transcriptional regulator. {ECO 0000269|Ref.6}. # IntAct P14407 6 # InterPro IPR004646 Fe-S_hydro-lyase_TtdA-typ_cat # InterPro IPR004647 Fe-S_hydro-lyase_TtdB-typ_cat # InterPro IPR011167 Fe_dep_fumarate_hydratase # InterPro IPR020557 Fumarate_lyase_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00020 Citrate cycle (TCA cycle) # KEGG_Pathway ko00720 Carbon fixation pathways in prokaryotes # Organism FUMB_ECOLI Escherichia coli (strain K12) # PATRIC 32123809 VBIEscCol129921_4253 # PIR A65222 B44511 # PIRSF PIRSF001394 Fe_dep_fumar_hy # PROSITE PS00163 FUMARATE_LYASES # Pfam PF05681 Fumerase # Pfam PF05683 Fumerase_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Fumarate hydratase class I, anaerobic {ECO:0000303|PubMed 3282546} # RefSeq NP_418546 NC_000913.3 # RefSeq WP_000066707 NZ_LN832404.1 # SIMILARITY Belongs to the class-I fumarase family. {ECO 0000305}. # SUBUNIT FUMB_ECOLI Homodimer. {ECO 0000269|PubMed 23405168, ECO 0000269|PubMed 3282546}. # SUPFAM SSF117457 SSF117457 # TIGRFAMs TIGR00722 ttdA_fumA_fumB # TIGRFAMs TIGR00723 ttdB_fumA_fumB # eggNOG COG1838 LUCA # eggNOG COG1951 LUCA # eggNOG ENOG4107GFK Bacteria BLAST swissprot:FUMB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FUMB_ECOLI BioCyc ECOL316407:JW4083-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4083-MONOMER BioCyc EcoCyc:FUMB-MONOMER http://biocyc.org/getid?id=EcoCyc:FUMB-MONOMER BioCyc MetaCyc:FUMB-MONOMER http://biocyc.org/getid?id=MetaCyc:FUMB-MONOMER COG COG1838 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1838 COG COG1951 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1951 DOI 10.1007/s00203-007-0279-9 http://dx.doi.org/10.1007/s00203-007-0279-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1099/00221287-131-11-2971 http://dx.doi.org/10.1099/00221287-131-11-2971 DOI 10.1111/j.1574-6968.1987.tb02545.x http://dx.doi.org/10.1111/j.1574-6968.1987.tb02545.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pone.0055549 http://dx.doi.org/10.1371/journal.pone.0055549 EC_number EC:4.2.1.2 {ECO:0000269|PubMed:23405168} http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.2 {ECO:0000269|PubMed:23405168} EC_number EC:4.2.1.81 {ECO:0000269|PubMed:23405168} http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.81 {ECO:0000269|PubMed:23405168} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M27058 http://www.ebi.ac.uk/ena/data/view/M27058 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 4.2.1.2 {ECO:0000269|PubMed:23405168} http://enzyme.expasy.org/EC/4.2.1.2 {ECO:0000269|PubMed:23405168} ENZYME 4.2.1.81 {ECO:0000269|PubMed:23405168} http://enzyme.expasy.org/EC/4.2.1.81 {ECO:0000269|PubMed:23405168} EchoBASE EB0352 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0352 EcoGene EG10357 http://www.ecogene.org/geneInfo.php?eg_id=EG10357 EnsemblBacteria AAC77083 http://www.ensemblgenomes.org/id/AAC77083 EnsemblBacteria AAC77083 http://www.ensemblgenomes.org/id/AAC77083 EnsemblBacteria BAE78124 http://www.ensemblgenomes.org/id/BAE78124 EnsemblBacteria BAE78124 http://www.ensemblgenomes.org/id/BAE78124 EnsemblBacteria BAE78124 http://www.ensemblgenomes.org/id/BAE78124 EnsemblBacteria b4122 http://www.ensemblgenomes.org/id/b4122 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004333 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004333 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0047808 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047808 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0006099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006099 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0044010 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044010 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.130.10 http://www.cathdb.info/version/latest/superfamily/3.20.130.10 GeneID 948642 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948642 HOGENOM HOG000009338 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009338&db=HOGENOM6 InParanoid P14407 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P14407 IntAct P14407 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P14407* IntEnz 4.2.1.2 {ECO:0000269|PubMed:23405168} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.2 {ECO:0000269|PubMed:23405168} IntEnz 4.2.1.81 {ECO:0000269|PubMed:23405168} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.81 {ECO:0000269|PubMed:23405168} InterPro IPR004646 http://www.ebi.ac.uk/interpro/entry/IPR004646 InterPro IPR004647 http://www.ebi.ac.uk/interpro/entry/IPR004647 InterPro IPR011167 http://www.ebi.ac.uk/interpro/entry/IPR011167 InterPro IPR020557 http://www.ebi.ac.uk/interpro/entry/IPR020557 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4083 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4083 KEGG_Gene eco:b4122 http://www.genome.jp/dbget-bin/www_bget?eco:b4122 KEGG_Orthology KO:K01676 http://www.genome.jp/dbget-bin/www_bget?KO:K01676 KEGG_Pathway ko00020 http://www.genome.jp/kegg-bin/show_pathway?ko00020 KEGG_Pathway ko00720 http://www.genome.jp/kegg-bin/show_pathway?ko00720 KEGG_Reaction rn:R01082 http://www.genome.jp/dbget-bin/www_bget?rn:R01082 OMA WAPNTET http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WAPNTET PROSITE PS00163 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00163 PSORT swissprot:FUMB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FUMB_ECOLI PSORT-B swissprot:FUMB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FUMB_ECOLI PSORT2 swissprot:FUMB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FUMB_ECOLI Pfam PF05681 http://pfam.xfam.org/family/PF05681 Pfam PF05683 http://pfam.xfam.org/family/PF05683 Phobius swissprot:FUMB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FUMB_ECOLI PhylomeDB P14407 http://phylomedb.org/?seqid=P14407 ProteinModelPortal P14407 http://www.proteinmodelportal.org/query/uniprot/P14407 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17643228 http://www.ncbi.nlm.nih.gov/pubmed/17643228 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 23405168 http://www.ncbi.nlm.nih.gov/pubmed/23405168 PubMed 2656658 http://www.ncbi.nlm.nih.gov/pubmed/2656658 PubMed 3005475 http://www.ncbi.nlm.nih.gov/pubmed/3005475 PubMed 3282546 http://www.ncbi.nlm.nih.gov/pubmed/3282546 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418546 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418546 RefSeq WP_000066707 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000066707 SMR P14407 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P14407 STRING 511145.b4122 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4122&targetmode=cogs STRING COG1838 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1838&targetmode=cogs STRING COG1951 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1951&targetmode=cogs SUPFAM SSF117457 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF117457 TIGRFAMs TIGR00722 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00722 TIGRFAMs TIGR00723 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00723 UniProtKB FUMB_ECOLI http://www.uniprot.org/uniprot/FUMB_ECOLI UniProtKB-AC P14407 http://www.uniprot.org/uniprot/P14407 charge swissprot:FUMB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FUMB_ECOLI eggNOG COG1838 http://eggnogapi.embl.de/nog_data/html/tree/COG1838 eggNOG COG1951 http://eggnogapi.embl.de/nog_data/html/tree/COG1951 eggNOG ENOG4107GFK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107GFK epestfind swissprot:FUMB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FUMB_ECOLI garnier swissprot:FUMB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FUMB_ECOLI helixturnhelix swissprot:FUMB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FUMB_ECOLI hmoment swissprot:FUMB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FUMB_ECOLI iep swissprot:FUMB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FUMB_ECOLI inforesidue swissprot:FUMB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FUMB_ECOLI octanol swissprot:FUMB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FUMB_ECOLI pepcoil swissprot:FUMB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FUMB_ECOLI pepdigest swissprot:FUMB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FUMB_ECOLI pepinfo swissprot:FUMB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FUMB_ECOLI pepnet swissprot:FUMB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FUMB_ECOLI pepstats swissprot:FUMB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FUMB_ECOLI pepwheel swissprot:FUMB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FUMB_ECOLI pepwindow swissprot:FUMB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FUMB_ECOLI sigcleave swissprot:FUMB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FUMB_ECOLI ## Database ID URL or Descriptions # BioGrid 4263033 89 # EcoGene EG12833 yhdV # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # Organism YHDV_ECOLI Escherichia coli (strain K12) # PATRIC 32121964 VBIEscCol129921_3366 # PIR E65119 E65119 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHDV_ECOLI Uncharacterized protein YhdV # RefSeq NP_417733 NC_000913.3 # RefSeq WP_000825639 NZ_LN832404.1 # SUBCELLULAR LOCATION YHDV_ECOLI Cell membrane {ECO 0000255|PROSITE- ProRule PRU00303}; Multi-pass membrane protein {ECO 0000305}. # eggNOG ENOG4105XCM Bacteria # eggNOG ENOG41124RN LUCA BLAST swissprot:YHDV_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHDV_ECOLI BioCyc ECOL316407:JW3235-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3235-MONOMER BioCyc EcoCyc:G7695-MONOMER http://biocyc.org/getid?id=EcoCyc:G7695-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2682 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2682 EcoGene EG12833 http://www.ecogene.org/geneInfo.php?eg_id=EG12833 EnsemblBacteria AAC76299 http://www.ensemblgenomes.org/id/AAC76299 EnsemblBacteria AAC76299 http://www.ensemblgenomes.org/id/AAC76299 EnsemblBacteria BAE77308 http://www.ensemblgenomes.org/id/BAE77308 EnsemblBacteria BAE77308 http://www.ensemblgenomes.org/id/BAE77308 EnsemblBacteria BAE77308 http://www.ensemblgenomes.org/id/BAE77308 EnsemblBacteria b3267 http://www.ensemblgenomes.org/id/b3267 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 947767 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947767 HOGENOM HOG000268028 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000268028&db=HOGENOM6 KEGG_Gene ecj:JW3235 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3235 KEGG_Gene eco:b3267 http://www.genome.jp/dbget-bin/www_bget?eco:b3267 OMA VHTNTCV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VHTNTCV PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YHDV_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHDV_ECOLI PSORT-B swissprot:YHDV_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHDV_ECOLI PSORT2 swissprot:YHDV_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHDV_ECOLI Phobius swissprot:YHDV_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHDV_ECOLI ProteinModelPortal P64622 http://www.proteinmodelportal.org/query/uniprot/P64622 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417733 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417733 RefSeq WP_000825639 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000825639 SMR P64622 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P64622 STRING 511145.b3267 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3267&targetmode=cogs UniProtKB YHDV_ECOLI http://www.uniprot.org/uniprot/YHDV_ECOLI UniProtKB-AC P64622 http://www.uniprot.org/uniprot/P64622 charge swissprot:YHDV_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHDV_ECOLI eggNOG ENOG4105XCM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105XCM eggNOG ENOG41124RN http://eggnogapi.embl.de/nog_data/html/tree/ENOG41124RN epestfind swissprot:YHDV_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHDV_ECOLI garnier swissprot:YHDV_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHDV_ECOLI helixturnhelix swissprot:YHDV_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHDV_ECOLI hmoment swissprot:YHDV_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHDV_ECOLI iep swissprot:YHDV_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHDV_ECOLI inforesidue swissprot:YHDV_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHDV_ECOLI octanol swissprot:YHDV_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHDV_ECOLI pepcoil swissprot:YHDV_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHDV_ECOLI pepdigest swissprot:YHDV_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHDV_ECOLI pepinfo swissprot:YHDV_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHDV_ECOLI pepnet swissprot:YHDV_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHDV_ECOLI pepstats swissprot:YHDV_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHDV_ECOLI pepwheel swissprot:YHDV_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHDV_ECOLI pepwindow swissprot:YHDV_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHDV_ECOLI sigcleave swissprot:YHDV_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHDV_ECOLI ## Database ID URL or Descriptions # BioGrid 4262802 218 # EcoGene EG10112 betT # FUNCTION BETT_ECOLI High-affinity uptake of choline driven by a proton- motive force. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; ISM:EcoCyc. # GO_function GO:0005215 transporter activity; IEA:InterPro. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0019285 glycine betaine biosynthetic process from choline; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # INDUCTION BETT_ECOLI By osmotic stress. Choline is required for full expression. # InterPro IPR000060 BCCT_transptr # InterPro IPR018093 BCCT_CS # KEGG_Brite ko02000 Transporters # Organism BETT_ECOLI Escherichia coli (strain K12) # PATHWAY BETT_ECOLI Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway. # PATRIC 32115757 VBIEscCol129921_0321 # PIR S15179 S15179 # PROSITE PS01303 BCCT # Pfam PF02028 BCCT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BETT_ECOLI High-affinity choline transport protein # RefSeq NP_414848 NC_000913.3 # RefSeq WP_000131044 NZ_LN832404.1 # SIMILARITY Belongs to the BCCT transporter (TC 2.A.15) family. {ECO 0000305}. # SUBCELLULAR LOCATION BETT_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # TCDB 2.A.15.1 the betaine/carnitine/choline transporter (bcct) family # TIGRFAMs TIGR00842 bcct # eggNOG COG1292 LUCA # eggNOG ENOG4105C94 Bacteria BLAST swissprot:BETT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BETT_ECOLI BioCyc ECOL316407:JW0306-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0306-MONOMER BioCyc EcoCyc:BETT-MONOMER http://biocyc.org/getid?id=EcoCyc:BETT-MONOMER BioCyc MetaCyc:BETT-MONOMER http://biocyc.org/getid?id=MetaCyc:BETT-MONOMER COG COG1292 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1292 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1991.tb01877.x http://dx.doi.org/10.1111/j.1365-2958.1991.tb01877.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EMBL X52905 http://www.ebi.ac.uk/ena/data/view/X52905 EchoBASE EB0110 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0110 EcoGene EG10112 http://www.ecogene.org/geneInfo.php?eg_id=EG10112 EnsemblBacteria AAC73417 http://www.ensemblgenomes.org/id/AAC73417 EnsemblBacteria AAC73417 http://www.ensemblgenomes.org/id/AAC73417 EnsemblBacteria BAE76097 http://www.ensemblgenomes.org/id/BAE76097 EnsemblBacteria BAE76097 http://www.ensemblgenomes.org/id/BAE76097 EnsemblBacteria BAE76097 http://www.ensemblgenomes.org/id/BAE76097 EnsemblBacteria b0314 http://www.ensemblgenomes.org/id/b0314 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0019285 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019285 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 945079 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945079 HOGENOM HOG000053241 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000053241&db=HOGENOM6 InParanoid P0ABC9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABC9 InterPro IPR000060 http://www.ebi.ac.uk/interpro/entry/IPR000060 InterPro IPR018093 http://www.ebi.ac.uk/interpro/entry/IPR018093 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0306 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0306 KEGG_Gene eco:b0314 http://www.genome.jp/dbget-bin/www_bget?eco:b0314 KEGG_Orthology KO:K02168 http://www.genome.jp/dbget-bin/www_bget?KO:K02168 OMA GWAMYAL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GWAMYAL PROSITE PS01303 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01303 PSORT swissprot:BETT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BETT_ECOLI PSORT-B swissprot:BETT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BETT_ECOLI PSORT2 swissprot:BETT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BETT_ECOLI Pfam PF02028 http://pfam.xfam.org/family/PF02028 Phobius swissprot:BETT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BETT_ECOLI PhylomeDB P0ABC9 http://phylomedb.org/?seqid=P0ABC9 ProteinModelPortal P0ABC9 http://www.proteinmodelportal.org/query/uniprot/P0ABC9 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1956285 http://www.ncbi.nlm.nih.gov/pubmed/1956285 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414848 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414848 RefSeq WP_000131044 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000131044 STRING 511145.b0314 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0314&targetmode=cogs STRING COG1292 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1292&targetmode=cogs TCDB 2.A.15.1 http://www.tcdb.org/search/result.php?tc=2.A.15.1 TIGRFAMs TIGR00842 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00842 UniProtKB BETT_ECOLI http://www.uniprot.org/uniprot/BETT_ECOLI UniProtKB-AC P0ABC9 http://www.uniprot.org/uniprot/P0ABC9 charge swissprot:BETT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BETT_ECOLI eggNOG COG1292 http://eggnogapi.embl.de/nog_data/html/tree/COG1292 eggNOG ENOG4105C94 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C94 epestfind swissprot:BETT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BETT_ECOLI garnier swissprot:BETT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BETT_ECOLI helixturnhelix swissprot:BETT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BETT_ECOLI hmoment swissprot:BETT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BETT_ECOLI iep swissprot:BETT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BETT_ECOLI inforesidue swissprot:BETT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BETT_ECOLI octanol swissprot:BETT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BETT_ECOLI pepcoil swissprot:BETT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BETT_ECOLI pepdigest swissprot:BETT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BETT_ECOLI pepinfo swissprot:BETT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BETT_ECOLI pepnet swissprot:BETT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BETT_ECOLI pepstats swissprot:BETT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BETT_ECOLI pepwheel swissprot:BETT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BETT_ECOLI pepwindow swissprot:BETT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BETT_ECOLI sigcleave swissprot:BETT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BETT_ECOLI ## Database ID URL or Descriptions # AltName PTXB_ECOLI PTS system EIIB component # CATALYTIC ACTIVITY Protein EIIB N(pi)-phospho-L- histidine/cysteine + sugar = protein EIIB + sugar phosphate. {ECO:0000255|PROSITE-ProRule PRU00421}. # CDD cd00212 PTS_IIB_glc # DOMAIN PTXB_ECOLI The EIIB domain is phosphorylated by phospho-EIIA on a cysteinyl or histidyl residue, depending on the transported sugar. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the EIIC domain. # EcoGene EG11709 glvB # FUNCTION PTXB_ECOLI The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. {ECO 0000250}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0008982 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:InterPro. # GO_function GO:0016301 kinase activity; IEA:UniProtKB-KW. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # Gene3D 3.30.1360.60 -; 1. # IntAct P69789 2 # InterPro IPR001996 PTS_IIB_1 # InterPro IPR018113 PTrfase_EIIB_Cys # Organism PTXB_ECOLI Escherichia coli (strain K12) # PATRIC 48666696 VBIEscCol107702_3618 # PIR C65170 C65170 # PROSITE PS01035 PTS_EIIB_TYPE_1_CYS # PROSITE PS51098 PTS_EIIB_TYPE_1 # Pfam PF00367 PTS_EIIB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PTXB_ECOLI Phosphotransferase enzyme IIB component GlvB # RefSeq WP_000492410 NZ_LN832404.1 # SIMILARITY Contains 1 PTS EIIB type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00421}. # SUBCELLULAR LOCATION PTXB_ECOLI Cell membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. # SUPFAM SSF55604 SSF55604 # TIGRFAMs TIGR00826 EIIB_glc # eggNOG COG1263 LUCA # eggNOG COG1264 LUCA BLAST swissprot:PTXB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTXB_ECOLI BioCyc ECOL316407:JW3659-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3659-MONOMER BioCyc EcoCyc:GLVB-MONOMER http://biocyc.org/getid?id=EcoCyc:GLVB-MONOMER BioCyc MetaCyc:GLVB-MONOMER http://biocyc.org/getid?id=MetaCyc:GLVB-MONOMER DOI 10.1002/pro.5560030309 http://dx.doi.org/10.1002/pro.5560030309 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.- http://enzyme.expasy.org/EC/2.7.1.- EchoBASE EB1660 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1660 EcoGene EG11709 http://www.ecogene.org/geneInfo.php?eg_id=EG11709 EnsemblBacteria BAE77612 http://www.ensemblgenomes.org/id/BAE77612 EnsemblBacteria BAE77612 http://www.ensemblgenomes.org/id/BAE77612 EnsemblBacteria BAE77612 http://www.ensemblgenomes.org/id/BAE77612 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008982 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008982 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.30.1360.60 http://www.cathdb.info/version/latest/superfamily/3.30.1360.60 IntAct P69789 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69789* IntEnz 2.7.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1 InterPro IPR001996 http://www.ebi.ac.uk/interpro/entry/IPR001996 InterPro IPR018113 http://www.ebi.ac.uk/interpro/entry/IPR018113 KEGG_Gene ecj:JW3659 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3659 OMA MNTDGNV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MNTDGNV PROSITE PS01035 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01035 PROSITE PS51098 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51098 PSORT swissprot:PTXB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTXB_ECOLI PSORT-B swissprot:PTXB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTXB_ECOLI PSORT2 swissprot:PTXB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTXB_ECOLI Pfam PF00367 http://pfam.xfam.org/family/PF00367 Phobius swissprot:PTXB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTXB_ECOLI PhylomeDB P69789 http://phylomedb.org/?seqid=P69789 ProteinModelPortal P69789 http://www.proteinmodelportal.org/query/uniprot/P69789 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 8019415 http://www.ncbi.nlm.nih.gov/pubmed/8019415 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000492410 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000492410 SMR P69789 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69789 STRING 316407.85676362 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85676362&targetmode=cogs SUPFAM SSF55604 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55604 TIGRFAMs TIGR00826 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00826 UniProtKB PTXB_ECOLI http://www.uniprot.org/uniprot/PTXB_ECOLI UniProtKB-AC P69789 http://www.uniprot.org/uniprot/P69789 charge swissprot:PTXB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTXB_ECOLI eggNOG COG1263 http://eggnogapi.embl.de/nog_data/html/tree/COG1263 eggNOG COG1264 http://eggnogapi.embl.de/nog_data/html/tree/COG1264 epestfind swissprot:PTXB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTXB_ECOLI garnier swissprot:PTXB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTXB_ECOLI helixturnhelix swissprot:PTXB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTXB_ECOLI hmoment swissprot:PTXB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTXB_ECOLI iep swissprot:PTXB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTXB_ECOLI inforesidue swissprot:PTXB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTXB_ECOLI octanol swissprot:PTXB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTXB_ECOLI pepcoil swissprot:PTXB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTXB_ECOLI pepdigest swissprot:PTXB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTXB_ECOLI pepinfo swissprot:PTXB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTXB_ECOLI pepnet swissprot:PTXB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTXB_ECOLI pepstats swissprot:PTXB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTXB_ECOLI pepwheel swissprot:PTXB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTXB_ECOLI pepwindow swissprot:PTXB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTXB_ECOLI sigcleave swissprot:PTXB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTXB_ECOLI ## Database ID URL or Descriptions # EcoGene EG10910 rpsK # FUNCTION RS11_ECOLI Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity). {ECO 0000250}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0022627 cytosolic small ribosomal subunit; IDA:EcoliWiki. # GO_function GO:0003735 structural constituent of ribosome; IDA:EcoliWiki. # GO_function GO:0048027 mRNA 5'-UTR binding; IBA:GO_Central. # GO_function GO:0070181 small ribosomal subunit rRNA binding; IDA:EcoliWiki. # GO_process GO:0000028 ribosomal small subunit assembly; IBA:GO_Central. # GO_process GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central. # GO_process GO:0006412 translation; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003729 mRNA binding # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_function GO:0019843 rRNA binding # GOslim_process GO:0006412 translation # GOslim_process GO:0022618 ribonucleoprotein complex assembly # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.30.420.80 -; 1. # HAMAP MF_01310 Ribosomal_S11 # IntAct P0A7R9 14 # InterPro IPR001971 Ribosomal_S11 # InterPro IPR018102 Ribosomal_S11_CS # InterPro IPR019981 Ribosomal_S11_bac-type # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 M00179 Ribosome, archaea # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=13727.7; Method=MALDI; Range=2-129; Evidence={ECO:0000269|PubMed 10094780}; # MISCELLANEOUS Has been predicted to contact the N-terminal domain of IF-3 based on footprint studies; exactly how IF-3 interacts with the 30S subunit is controversial. {ECO:0000305|PubMed 11684020}. # Organism RS11_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11759 PTHR11759 # PATRIC 32122026 VBIEscCol129921_3390 # PDB 1M5G Model; -; K=13-129 # PDB 2YKR EM; 9.80 A; K=13-129 # PDB 3J9Y EM; 3.90 A; k=1-129 # PDB 3J9Z EM; 3.60 A; SK=2-129 # PDB 3JA1 EM; 3.60 A; SK=2-129 # PDB 3JBU EM; 3.64 A; K=1-129 # PDB 3JBV EM; 3.32 A; K=1-129 # PDB 3JCD EM; 3.70 A; k=1-129 # PDB 3JCE EM; 3.20 A; k=1-129 # PDB 3JCJ EM; 3.70 A; q=1-129 # PDB 3JCN EM; 4.60 A; l=1-129 # PDB 4A2I EM; 16.50 A; K=13-129 # PDB 4ADV EM; 13.50 A; K=2-129 # PDB 4U1U X-ray; 2.95 A; AK/CK=13-129 # PDB 4U1V X-ray; 3.00 A; AK/CK=13-129 # PDB 4U20 X-ray; 2.90 A; AK/CK=13-129 # PDB 4U24 X-ray; 2.90 A; AK/CK=13-129 # PDB 4U25 X-ray; 2.90 A; AK/CK=13-129 # PDB 4U26 X-ray; 2.80 A; AK/CK=13-129 # PDB 4U27 X-ray; 2.80 A; AK/CK=13-129 # PDB 4V47 EM; 12.30 A; BK=2-129 # PDB 4V48 EM; 11.50 A; BK=2-129 # PDB 4V4H X-ray; 3.46 A; AK/CK=1-129 # PDB 4V4Q X-ray; 3.46 A; AK/CK=2-129 # PDB 4V4V EM; 15.00 A; AK=13-128 # PDB 4V4W EM; 15.00 A; AK=13-128 # PDB 4V50 X-ray; 3.22 A; AK/CK=2-129 # PDB 4V52 X-ray; 3.21 A; AK/CK=2-129 # PDB 4V53 X-ray; 3.54 A; AK/CK=2-129 # PDB 4V54 X-ray; 3.30 A; AK/CK=2-129 # PDB 4V55 X-ray; 4.00 A; AK/CK=2-129 # PDB 4V56 X-ray; 3.93 A; AK/CK=2-129 # PDB 4V57 X-ray; 3.50 A; AK/CK=2-129 # PDB 4V5B X-ray; 3.74 A; BK/DK=2-129 # PDB 4V5H EM; 5.80 A; AK=13-129 # PDB 4V5Y X-ray; 4.45 A; AK/CK=2-129 # PDB 4V64 X-ray; 3.50 A; AK/CK=2-129 # PDB 4V65 EM; 9.00 A; AC=1-129 # PDB 4V66 EM; 9.00 A; AC=1-129 # PDB 4V69 EM; 6.70 A; AK=13-129 # PDB 4V6C X-ray; 3.19 A; AK/CK=1-129 # PDB 4V6D X-ray; 3.81 A; AK/CK=1-129 # PDB 4V6E X-ray; 3.71 A; AK/CK=1-129 # PDB 4V6K EM; 8.25 A; BO=1-129 # PDB 4V6L EM; 13.20 A; AO=1-129 # PDB 4V6M EM; 7.10 A; AK=2-129 # PDB 4V6N EM; 12.10 A; BN=2-129 # PDB 4V6O EM; 14.70 A; AN=2-129 # PDB 4V6P EM; 13.50 A; AN=2-129 # PDB 4V6Q EM; 11.50 A; AN=2-129 # PDB 4V6R EM; 11.50 A; AN=2-129 # PDB 4V6S EM; 13.10 A; BM=2-129 # PDB 4V6T EM; 8.30 A; AK=13-129 # PDB 4V6V EM; 9.80 A; AK=2-129 # PDB 4V6Y EM; 12.00 A; AK=13-129 # PDB 4V6Z EM; 12.00 A; AK=13-129 # PDB 4V70 EM; 17.00 A; AK=13-129 # PDB 4V71 EM; 20.00 A; AK=13-129 # PDB 4V72 EM; 13.00 A; AK=13-129 # PDB 4V73 EM; 15.00 A; AK=13-129 # PDB 4V74 EM; 17.00 A; AK=13-129 # PDB 4V75 EM; 12.00 A; AK=13-129 # PDB 4V76 EM; 17.00 A; AK=13-129 # PDB 4V77 EM; 17.00 A; AK=13-129 # PDB 4V78 EM; 20.00 A; AK=13-129 # PDB 4V79 EM; 15.00 A; AK=13-129 # PDB 4V7A EM; 9.00 A; AK=13-129 # PDB 4V7B EM; 6.80 A; AK=1-129 # PDB 4V7C EM; 7.60 A; AK=2-129 # PDB 4V7D EM; 7.60 A; BK=2-129 # PDB 4V7I EM; 9.60 A; BK=1-129 # PDB 4V7S X-ray; 3.25 A; AK/CK=13-129 # PDB 4V7T X-ray; 3.19 A; AK/CK=13-129 # PDB 4V7U X-ray; 3.10 A; AK/CK=13-129 # PDB 4V7V X-ray; 3.29 A; AK/CK=13-129 # PDB 4V85 X-ray; 3.20 A; AK=1-129 # PDB 4V89 X-ray; 3.70 A; AK=1-129 # PDB 4V9C X-ray; 3.30 A; AK/CK=1-129 # PDB 4V9D X-ray; 3.00 A; AK/BK=13-129 # PDB 4V9O X-ray; 2.90 A; BK/DK/FK/HK=1-129 # PDB 4V9P X-ray; 2.90 A; BK/DK/FK/HK=1-129 # PDB 4WF1 X-ray; 3.09 A; AK/CK=13-129 # PDB 4WOI X-ray; 3.00 A; AK/DK=1-129 # PDB 4WWW X-ray; 3.10 A; QK/XK=13-129 # PDB 4YBB X-ray; 2.10 A; AK/BK=13-129 # PDB 5AFI EM; 2.90 A; k=1-129 # PDB 5IQR EM; 3.00 A; p=1-129 # PDB 5IT8 X-ray; 3.12 A; AK/BK=13-129 # PDB 5J5B X-ray; 2.80 A; AK/BK=13-129 # PDB 5J7L X-ray; 3.00 A; AK/BK=13-129 # PDB 5J88 X-ray; 3.32 A; AK/BK=1-129 # PDB 5J8A X-ray; 3.10 A; AK/BK=13-129 # PDB 5J91 X-ray; 2.96 A; AK/BK=13-129 # PDB 5JC9 X-ray; 3.03 A; AK/BK=13-129 # PDB 5JTE EM; 3.60 A; AK=1-129 # PDB 5JU8 EM; 3.60 A; AK=1-129 # PDB 5KCR EM; 3.60 A; 1k=1-129 # PDB 5KCS EM; 3.90 A; 1k=1-129 # PDB 5KPS EM; 3.90 A; 16=1-129 # PDB 5KPV EM; 4.10 A; 15=1-129 # PDB 5KPW EM; 3.90 A; 15=1-129 # PDB 5KPX EM; 3.90 A; 15=1-129 # PDB 5L3P EM; 3.70 A; k=1-129 # PIR B23807 R3EC11 # PIRSF PIRSF002131 Ribosomal_S11 # PROSITE PS00054 RIBOSOMAL_S11 # Pfam PF00411 Ribosomal_S11 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RS11_ECOLI 30S ribosomal protein S11 # RefSeq NP_417756 NC_000913.3 # RefSeq WP_001029684 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein S11P family. {ECO 0000305}. # SUBUNIT Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18 (By similarity). Cross-links to IF-3. {ECO 0000250}. # TIGRFAMs TIGR03632 uS11_bact # eggNOG COG0100 LUCA BLAST swissprot:RS11_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RS11_ECOLI BioCyc ECOL316407:JW3259-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3259-MONOMER BioCyc EcoCyc:EG10910-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10910-MONOMER BioCyc MetaCyc:EG10910-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10910-MONOMER COG COG0100 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0100 DIP DIP-47838N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47838N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1016/0003-9861(81)90544-0 http://dx.doi.org/10.1016/0003-9861(81)90544-0 DOI 10.1016/0014-5793(80)81278-6 http://dx.doi.org/10.1016/0014-5793(80)81278-6 DOI 10.1016/S0092-8674(03)00427-6 http://dx.doi.org/10.1016/S0092-8674(03)00427-6 DOI 10.1016/S1097-2765(01)00356-2 http://dx.doi.org/10.1016/S1097-2765(01)00356-2 DOI 10.1021/bi00282a020 http://dx.doi.org/10.1021/bi00282a020 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb841 http://dx.doi.org/10.1038/nsb841 DOI 10.1093/nar/13.11.3891 http://dx.doi.org/10.1093/nar/13.11.3891 DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X02543 http://www.ebi.ac.uk/ena/data/view/X02543 EchoBASE EB0903 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0903 EcoGene EG10910 http://www.ecogene.org/geneInfo.php?eg_id=EG10910 EnsemblBacteria AAC76322 http://www.ensemblgenomes.org/id/AAC76322 EnsemblBacteria AAC76322 http://www.ensemblgenomes.org/id/AAC76322 EnsemblBacteria BAE77994 http://www.ensemblgenomes.org/id/BAE77994 EnsemblBacteria BAE77994 http://www.ensemblgenomes.org/id/BAE77994 EnsemblBacteria BAE77994 http://www.ensemblgenomes.org/id/BAE77994 EnsemblBacteria b3297 http://www.ensemblgenomes.org/id/b3297 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0022627 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022627 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_function GO:0048027 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048027 GO_function GO:0070181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070181 GO_process GO:0000028 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000028 GO_process GO:0000462 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000462 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003729 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003729 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_process GO:0022618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022618 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.30.420.80 http://www.cathdb.info/version/latest/superfamily/3.30.420.80 GeneID 24908374 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24908374 GeneID 947792 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947792 HAMAP MF_01310 http://hamap.expasy.org/unirule/MF_01310 HOGENOM HOG000111598 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000111598&db=HOGENOM6 InParanoid P0A7R9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7R9 IntAct P0A7R9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7R9* InterPro IPR001971 http://www.ebi.ac.uk/interpro/entry/IPR001971 InterPro IPR018102 http://www.ebi.ac.uk/interpro/entry/IPR018102 InterPro IPR019981 http://www.ebi.ac.uk/interpro/entry/IPR019981 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW3259 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3259 KEGG_Gene eco:b3297 http://www.genome.jp/dbget-bin/www_bget?eco:b3297 KEGG_Orthology KO:K02948 http://www.genome.jp/dbget-bin/www_bget?KO:K02948 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 MINT MINT-1232137 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1232137 OMA NTPYASQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NTPYASQ PANTHER PTHR11759 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11759 PDB 1M5G http://www.ebi.ac.uk/pdbe-srv/view/entry/1M5G PDB 2YKR http://www.ebi.ac.uk/pdbe-srv/view/entry/2YKR PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 4A2I http://www.ebi.ac.uk/pdbe-srv/view/entry/4A2I PDB 4ADV http://www.ebi.ac.uk/pdbe-srv/view/entry/4ADV PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4V47 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V47 PDB 4V48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V48 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 1M5G http://www.ebi.ac.uk/pdbsum/1M5G PDBsum 2YKR http://www.ebi.ac.uk/pdbsum/2YKR PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 4A2I http://www.ebi.ac.uk/pdbsum/4A2I PDBsum 4ADV http://www.ebi.ac.uk/pdbsum/4ADV PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4V47 http://www.ebi.ac.uk/pdbsum/4V47 PDBsum 4V48 http://www.ebi.ac.uk/pdbsum/4V48 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PROSITE PS00054 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00054 PSORT swissprot:RS11_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RS11_ECOLI PSORT-B swissprot:RS11_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RS11_ECOLI PSORT2 swissprot:RS11_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RS11_ECOLI Pfam PF00411 http://pfam.xfam.org/family/PF00411 Phobius swissprot:RS11_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RS11_ECOLI PhylomeDB P0A7R9 http://phylomedb.org/?seqid=P0A7R9 ProteinModelPortal P0A7R9 http://www.proteinmodelportal.org/query/uniprot/P0A7R9 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 11684020 http://www.ncbi.nlm.nih.gov/pubmed/11684020 PubMed 12244297 http://www.ncbi.nlm.nih.gov/pubmed/12244297 PubMed 12809609 http://www.ncbi.nlm.nih.gov/pubmed/12809609 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2989779 http://www.ncbi.nlm.nih.gov/pubmed/2989779 PubMed 6349681 http://www.ncbi.nlm.nih.gov/pubmed/6349681 PubMed 7000779 http://www.ncbi.nlm.nih.gov/pubmed/7000779 PubMed 7007074 http://www.ncbi.nlm.nih.gov/pubmed/7007074 PubMed 7020604 http://www.ncbi.nlm.nih.gov/pubmed/7020604 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417756 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417756 RefSeq WP_001029684 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001029684 SMR P0A7R9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7R9 STRING 511145.b3297 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3297&targetmode=cogs STRING COG0100 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0100&targetmode=cogs TIGRFAMs TIGR03632 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03632 UniProtKB RS11_ECOLI http://www.uniprot.org/uniprot/RS11_ECOLI UniProtKB-AC P0A7R9 http://www.uniprot.org/uniprot/P0A7R9 charge swissprot:RS11_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RS11_ECOLI eggNOG COG0100 http://eggnogapi.embl.de/nog_data/html/tree/COG0100 epestfind swissprot:RS11_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RS11_ECOLI garnier swissprot:RS11_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RS11_ECOLI helixturnhelix swissprot:RS11_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RS11_ECOLI hmoment swissprot:RS11_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RS11_ECOLI iep swissprot:RS11_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RS11_ECOLI inforesidue swissprot:RS11_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RS11_ECOLI octanol swissprot:RS11_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RS11_ECOLI pepcoil swissprot:RS11_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RS11_ECOLI pepdigest swissprot:RS11_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RS11_ECOLI pepinfo swissprot:RS11_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RS11_ECOLI pepnet swissprot:RS11_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RS11_ECOLI pepstats swissprot:RS11_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RS11_ECOLI pepwheel swissprot:RS11_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RS11_ECOLI pepwindow swissprot:RS11_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RS11_ECOLI sigcleave swissprot:RS11_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RS11_ECOLI ## Database ID URL or Descriptions # AltName OMPN_ECOLI Porin OmpN # BioGrid 4260172 280 # CDD cd00342 gram_neg_porins # EcoGene EG13375 ompN # FUNCTION OMPN_ECOLI Forms pores that allow passive diffusion of small molecules across the outer membrane (By similarity). Non-specific porin. {ECO 0000250}. # GO_component GO:0009279 cell outer membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016020 membrane; IDA:EcoCyc. # GO_component GO:0046930 pore complex; IEA:UniProtKB-KW. # GO_function GO:0015288 porin activity; IDA:EcoCyc. # GO_process GO:0006811 ion transport; IEA:UniProtKB-KW. # GO_process GO:0034219 carbohydrate transmembrane transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043234 protein complex # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # Gene3D 2.40.160.10 -; 1. # InterPro IPR001702 Porin_Gram-ve # InterPro IPR001897 Porin_gammaproteobac # InterPro IPR023614 Porin_dom # InterPro IPR033900 Gram_neg_porin_domain # KEGG_Brite ko02000 Transporters # Organism OMPN_ECOLI Escherichia coli (strain K12) # PATRIC 32118038 VBIEscCol129921_1439 # PIR D64888 D64888 # PRINTS PR00182 ECOLNEIPORIN # PRINTS PR00183 ECOLIPORIN # Pfam PF00267 Porin_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName OMPN_ECOLI Outer membrane protein N # RefSeq NP_415895 NC_000913.3 # RefSeq WP_000837921 NZ_LN832404.1 # SIMILARITY Belongs to the Gram-negative porin family. {ECO 0000305}. # SUBCELLULAR LOCATION OMPN_ECOLI Cell outer membrane; Multi-pass membrane protein. # SUBUNIT OMPN_ECOLI Homotrimer. # TCDB 1.B.1.1.21 the general bacterial porin (gbp) family # eggNOG COG3203 LUCA # eggNOG ENOG4105FCK Bacteria BLAST swissprot:OMPN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:OMPN_ECOLI BioCyc ECOL316407:JW1371-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1371-MONOMER BioCyc EcoCyc:G6700-MONOMER http://biocyc.org/getid?id=EcoCyc:G6700-MONOMER COG COG3203 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3203 DIP DIP-10400N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10400N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3157 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3157 EcoGene EG13375 http://www.ecogene.org/geneInfo.php?eg_id=EG13375 EnsemblBacteria AAC74459 http://www.ensemblgenomes.org/id/AAC74459 EnsemblBacteria AAC74459 http://www.ensemblgenomes.org/id/AAC74459 EnsemblBacteria BAA14981 http://www.ensemblgenomes.org/id/BAA14981 EnsemblBacteria BAA14981 http://www.ensemblgenomes.org/id/BAA14981 EnsemblBacteria BAA14981 http://www.ensemblgenomes.org/id/BAA14981 EnsemblBacteria b1377 http://www.ensemblgenomes.org/id/b1377 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0046930 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046930 GO_function GO:0015288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015288 GO_process GO:0006811 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811 GO_process GO:0034219 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034219 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 2.40.160.10 http://www.cathdb.info/version/latest/superfamily/2.40.160.10 GeneID 946313 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946313 HOGENOM HOG000272406 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000272406&db=HOGENOM6 InParanoid P77747 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77747 InterPro IPR001702 http://www.ebi.ac.uk/interpro/entry/IPR001702 InterPro IPR001897 http://www.ebi.ac.uk/interpro/entry/IPR001897 InterPro IPR023614 http://www.ebi.ac.uk/interpro/entry/IPR023614 InterPro IPR033900 http://www.ebi.ac.uk/interpro/entry/IPR033900 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1371 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1371 KEGG_Gene eco:b1377 http://www.genome.jp/dbget-bin/www_bget?eco:b1377 KEGG_Orthology KO:K14062 http://www.genome.jp/dbget-bin/www_bget?KO:K14062 OMA NGRDIRH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NGRDIRH PRINTS PR00182 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00182 PRINTS PR00183 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00183 PSORT swissprot:OMPN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:OMPN_ECOLI PSORT-B swissprot:OMPN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:OMPN_ECOLI PSORT2 swissprot:OMPN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:OMPN_ECOLI Pfam PF00267 http://pfam.xfam.org/family/PF00267 Phobius swissprot:OMPN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:OMPN_ECOLI PhylomeDB P77747 http://phylomedb.org/?seqid=P77747 ProteinModelPortal P77747 http://www.proteinmodelportal.org/query/uniprot/P77747 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9642192 http://www.ncbi.nlm.nih.gov/pubmed/9642192 RefSeq NP_415895 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415895 RefSeq WP_000837921 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000837921 SMR P77747 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77747 STRING 511145.b1377 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1377&targetmode=cogs STRING COG3203 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3203&targetmode=cogs TCDB 1.B.1.1.21 http://www.tcdb.org/search/result.php?tc=1.B.1.1.21 UniProtKB OMPN_ECOLI http://www.uniprot.org/uniprot/OMPN_ECOLI UniProtKB-AC P77747 http://www.uniprot.org/uniprot/P77747 charge swissprot:OMPN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:OMPN_ECOLI eggNOG COG3203 http://eggnogapi.embl.de/nog_data/html/tree/COG3203 eggNOG ENOG4105FCK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FCK epestfind swissprot:OMPN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:OMPN_ECOLI garnier swissprot:OMPN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:OMPN_ECOLI helixturnhelix swissprot:OMPN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:OMPN_ECOLI hmoment swissprot:OMPN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:OMPN_ECOLI iep swissprot:OMPN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:OMPN_ECOLI inforesidue swissprot:OMPN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:OMPN_ECOLI octanol swissprot:OMPN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:OMPN_ECOLI pepcoil swissprot:OMPN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:OMPN_ECOLI pepdigest swissprot:OMPN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:OMPN_ECOLI pepinfo swissprot:OMPN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:OMPN_ECOLI pepnet swissprot:OMPN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:OMPN_ECOLI pepstats swissprot:OMPN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:OMPN_ECOLI pepwheel swissprot:OMPN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:OMPN_ECOLI pepwindow swissprot:OMPN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:OMPN_ECOLI sigcleave swissprot:OMPN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:OMPN_ECOLI ## Database ID URL or Descriptions # BioGrid 4259778 11 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG13549 yagJ # IntAct P77169 7 # Organism YAGJ_ECOLI Escherichia coli (strain K12) # PATRIC 48659756 VBIEscCol107702_0273 # PIR D64753 D64753 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAGJ_ECOLI Putative uncharacterized protein YagJ # RefSeq WP_000388269 NZ_LN832404.1 BLAST swissprot:YAGJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAGJ_ECOLI BioCyc ECOL316407:JW0270-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0270-MONOMER BioCyc EcoCyc:G6147-MONOMER http://biocyc.org/getid?id=EcoCyc:G6147-MONOMER DIP DIP-11237N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11237N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EchoBASE EB3319 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3319 EcoGene EG13549 http://www.ecogene.org/geneInfo.php?eg_id=EG13549 EnsemblBacteria BAE76060 http://www.ensemblgenomes.org/id/BAE76060 EnsemblBacteria BAE76060 http://www.ensemblgenomes.org/id/BAE76060 EnsemblBacteria BAE76060 http://www.ensemblgenomes.org/id/BAE76060 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv HOGENOM HOG000054876 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000054876&db=HOGENOM6 IntAct P77169 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77169* KEGG_Gene ecj:JW0270 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0270 MINT MINT-1320960 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1320960 PSORT swissprot:YAGJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAGJ_ECOLI PSORT-B swissprot:YAGJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAGJ_ECOLI PSORT2 swissprot:YAGJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAGJ_ECOLI Phobius swissprot:YAGJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAGJ_ECOLI ProteinModelPortal P77169 http://www.proteinmodelportal.org/query/uniprot/P77169 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000388269 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000388269 STRING 316407.85674420 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85674420&targetmode=cogs UniProtKB YAGJ_ECOLI http://www.uniprot.org/uniprot/YAGJ_ECOLI UniProtKB-AC P77169 http://www.uniprot.org/uniprot/P77169 charge swissprot:YAGJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAGJ_ECOLI epestfind swissprot:YAGJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAGJ_ECOLI garnier swissprot:YAGJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAGJ_ECOLI helixturnhelix swissprot:YAGJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAGJ_ECOLI hmoment swissprot:YAGJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAGJ_ECOLI iep swissprot:YAGJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAGJ_ECOLI inforesidue swissprot:YAGJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAGJ_ECOLI octanol swissprot:YAGJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAGJ_ECOLI pepcoil swissprot:YAGJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAGJ_ECOLI pepdigest swissprot:YAGJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAGJ_ECOLI pepinfo swissprot:YAGJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAGJ_ECOLI pepnet swissprot:YAGJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAGJ_ECOLI pepstats swissprot:YAGJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAGJ_ECOLI pepwheel swissprot:YAGJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAGJ_ECOLI pepwindow swissprot:YAGJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAGJ_ECOLI sigcleave swissprot:YAGJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAGJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4262286 16 # CATALYTIC ACTIVITY BARA_ECOLI ATP + protein L-histidine = ADP + protein N- phospho-L-histidine. # CDD cd06225 HAMP # EcoGene EG11367 barA # FUNCTION BARA_ECOLI Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0000155 phosphorelay sensor kinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0009927 histidine phosphotransfer kinase activity; IDA:EcoliWiki. # GO_process GO:0000160 phosphorelay signal transduction system; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006468 protein phosphorylation; IDA:EcoliWiki. # GO_process GO:0042542 response to hydrogen peroxide; IMP:EcoliWiki. # GO_process GO:0046777 protein autophosphorylation; IDA:EcoliWiki. # GO_process GO:0071310 cellular response to organic substance; IEP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005622 intracellular # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.287.130 -; 1. # Gene3D 1.20.120.160 -; 1. # Gene3D 3.30.565.10 -; 1. # IntAct P0AEC5 4 # InterPro IPR001789 Sig_transdc_resp-reg_receiver # InterPro IPR003594 HATPase_C # InterPro IPR003660 HAMP_dom # InterPro IPR003661 HisK_dim/P # InterPro IPR004358 Sig_transdc_His_kin-like_C # InterPro IPR005467 His_kinase_dom # InterPro IPR008207 Sig_transdc_His_kin_Hpt_dom # InterPro IPR011006 CheY-like_superfamily # InterPro IPR019247 Histidine_kinase_BarA_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01001 Protein kinases # KEGG_Brite ko02022 M00475 BarA-UvrY (central carbon metabolism) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # Organism BARA_ECOLI Escherichia coli (strain K12) # PATRIC 32120988 VBIEscCol129921_2886 # PIR S20550 S20550 # PRINTS PR00344 BCTRLSENSOR # PROSITE PS50109 HIS_KIN # PROSITE PS50110 RESPONSE_REGULATORY # PROSITE PS50885 HAMP # PROSITE PS50894 HPT # PTM BARA_ECOLI Activation requires a sequential transfer of a phosphate group from a His in the primary transmitter domain, to an Asp in the receiver domain and to a His in the secondary transmitter domain. {ECO 0000250}. # Pfam PF00072 Response_reg # Pfam PF00512 HisKA # Pfam PF00672 HAMP # Pfam PF01627 Hpt # Pfam PF02518 HATPase_c # Pfam PF09984 DUF2222 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BARA_ECOLI Signal transduction histidine-protein kinase BarA # RefSeq NP_417266 NC_000913.3 # RefSeq WP_000186450 NZ_LN832404.1 # SIMILARITY Contains 1 HAMP domain. {ECO:0000255|PROSITE- ProRule PRU00102}. # SIMILARITY Contains 1 HPt domain. {ECO:0000255|PROSITE- ProRule PRU00110}. # SIMILARITY Contains 1 histidine kinase domain. {ECO:0000255|PROSITE-ProRule PRU00107}. # SIMILARITY Contains 1 response regulatory domain. {ECO:0000255|PROSITE-ProRule PRU00169}. # SMART SM00073 HPT # SMART SM00304 HAMP # SMART SM00387 HATPase_c # SMART SM00388 HisKA # SMART SM00448 REC # SUBCELLULAR LOCATION BARA_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # SUPFAM SSF47226 SSF47226; 2 # SUPFAM SSF47384 SSF47384 # SUPFAM SSF52172 SSF52172 # SUPFAM SSF55874 SSF55874 # eggNOG COG0784 LUCA # eggNOG COG2198 LUCA # eggNOG COG4999 LUCA # eggNOG ENOG4105BZU Bacteria BLAST swissprot:BARA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BARA_ECOLI BioCyc ECOL316407:JW2757-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2757-MONOMER BioCyc EcoCyc:BARA-MONOMER http://biocyc.org/getid?id=EcoCyc:BARA-MONOMER DIP DIP-47932N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47932N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M001550200 http://dx.doi.org/10.1074/jbc.M001550200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1365-2958.1992.tb01530.x http://dx.doi.org/10.1111/j.1365-2958.1992.tb01530.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.18.5130-5140.2002 http://dx.doi.org/10.1128/JB.184.18.5130-5140.2002 DOI 10.1128/JB.185.3.843-853.2003 http://dx.doi.org/10.1128/JB.185.3.843-853.2003 EC_number EC:2.7.13.3 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.13.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D10888 http://www.ebi.ac.uk/ena/data/view/D10888 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29580 http://www.ebi.ac.uk/ena/data/view/U29580 ENZYME 2.7.13.3 http://enzyme.expasy.org/EC/2.7.13.3 EchoBASE EB1341 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1341 EcoGene EG11367 http://www.ecogene.org/geneInfo.php?eg_id=EG11367 EnsemblBacteria AAC75828 http://www.ensemblgenomes.org/id/AAC75828 EnsemblBacteria AAC75828 http://www.ensemblgenomes.org/id/AAC75828 EnsemblBacteria BAA16571 http://www.ensemblgenomes.org/id/BAA16571 EnsemblBacteria BAA16571 http://www.ensemblgenomes.org/id/BAA16571 EnsemblBacteria BAA16571 http://www.ensemblgenomes.org/id/BAA16571 EnsemblBacteria b2786 http://www.ensemblgenomes.org/id/b2786 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0000155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000155 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0009927 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009927 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0006468 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006468 GO_process GO:0042542 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042542 GO_process GO:0046777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046777 GO_process GO:0071310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071310 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.287.130 http://www.cathdb.info/version/latest/superfamily/1.10.287.130 Gene3D 1.20.120.160 http://www.cathdb.info/version/latest/superfamily/1.20.120.160 Gene3D 3.30.565.10 http://www.cathdb.info/version/latest/superfamily/3.30.565.10 GeneID 947255 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947255 HOGENOM HOG000272329 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000272329&db=HOGENOM6 InParanoid P0AEC5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEC5 IntAct P0AEC5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEC5* IntEnz 2.7.13.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.13.3 InterPro IPR001789 http://www.ebi.ac.uk/interpro/entry/IPR001789 InterPro IPR003594 http://www.ebi.ac.uk/interpro/entry/IPR003594 InterPro IPR003660 http://www.ebi.ac.uk/interpro/entry/IPR003660 InterPro IPR003661 http://www.ebi.ac.uk/interpro/entry/IPR003661 InterPro IPR004358 http://www.ebi.ac.uk/interpro/entry/IPR004358 InterPro IPR005467 http://www.ebi.ac.uk/interpro/entry/IPR005467 InterPro IPR008207 http://www.ebi.ac.uk/interpro/entry/IPR008207 InterPro IPR011006 http://www.ebi.ac.uk/interpro/entry/IPR011006 InterPro IPR019247 http://www.ebi.ac.uk/interpro/entry/IPR019247 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01001 http://www.genome.jp/dbget-bin/www_bget?ko01001 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW2757 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2757 KEGG_Gene eco:b2786 http://www.genome.jp/dbget-bin/www_bget?eco:b2786 KEGG_Orthology KO:K07678 http://www.genome.jp/dbget-bin/www_bget?KO:K07678 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 MINT MINT-1307958 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1307958 OMA ISHMVSV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ISHMVSV PRINTS PR00344 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00344 PROSITE PS50109 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50109 PROSITE PS50110 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50110 PROSITE PS50885 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50885 PROSITE PS50894 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50894 PSORT swissprot:BARA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BARA_ECOLI PSORT-B swissprot:BARA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BARA_ECOLI PSORT2 swissprot:BARA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BARA_ECOLI Pfam PF00072 http://pfam.xfam.org/family/PF00072 Pfam PF00512 http://pfam.xfam.org/family/PF00512 Pfam PF00672 http://pfam.xfam.org/family/PF00672 Pfam PF01627 http://pfam.xfam.org/family/PF01627 Pfam PF02518 http://pfam.xfam.org/family/PF02518 Pfam PF09984 http://pfam.xfam.org/family/PF09984 Phobius swissprot:BARA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BARA_ECOLI PhylomeDB P0AEC5 http://phylomedb.org/?seqid=P0AEC5 ProteinModelPortal P0AEC5 http://www.proteinmodelportal.org/query/uniprot/P0AEC5 PubMed 11022030 http://www.ncbi.nlm.nih.gov/pubmed/11022030 PubMed 12193630 http://www.ncbi.nlm.nih.gov/pubmed/12193630 PubMed 12533459 http://www.ncbi.nlm.nih.gov/pubmed/12533459 PubMed 1574005 http://www.ncbi.nlm.nih.gov/pubmed/1574005 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417266 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417266 RefSeq WP_000186450 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000186450 SMART SM00073 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00073 SMART SM00304 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00304 SMART SM00387 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00387 SMART SM00388 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00388 SMART SM00448 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00448 SMR P0AEC5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEC5 STRING 511145.b2786 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2786&targetmode=cogs SUPFAM SSF47226 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47226 SUPFAM SSF47384 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47384 SUPFAM SSF52172 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52172 SUPFAM SSF55874 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55874 UniProtKB BARA_ECOLI http://www.uniprot.org/uniprot/BARA_ECOLI UniProtKB-AC P0AEC5 http://www.uniprot.org/uniprot/P0AEC5 charge swissprot:BARA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BARA_ECOLI eggNOG COG0784 http://eggnogapi.embl.de/nog_data/html/tree/COG0784 eggNOG COG2198 http://eggnogapi.embl.de/nog_data/html/tree/COG2198 eggNOG COG4999 http://eggnogapi.embl.de/nog_data/html/tree/COG4999 eggNOG ENOG4105BZU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZU epestfind swissprot:BARA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BARA_ECOLI garnier swissprot:BARA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BARA_ECOLI helixturnhelix swissprot:BARA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BARA_ECOLI hmoment swissprot:BARA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BARA_ECOLI iep swissprot:BARA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BARA_ECOLI inforesidue swissprot:BARA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BARA_ECOLI octanol swissprot:BARA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BARA_ECOLI pepcoil swissprot:BARA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BARA_ECOLI pepdigest swissprot:BARA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BARA_ECOLI pepinfo swissprot:BARA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BARA_ECOLI pepnet swissprot:BARA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BARA_ECOLI pepstats swissprot:BARA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BARA_ECOLI pepwheel swissprot:BARA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BARA_ECOLI pepwindow swissprot:BARA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BARA_ECOLI sigcleave swissprot:BARA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BARA_ECOLI ## Database ID URL or Descriptions # AltName YHAV_ECOLI Ribonuclease YhaV # BioGrid 4262413 9 # EcoGene EG12761 yhaV # FUNCTION YHAV_ECOLI Toxic component of a toxin-antitoxin (TA) module. Has RNase activity in vitro. Overexpression leads to growth arrest after 30 minutes; these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV/PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression. {ECO 0000269|PubMed 17706670}. # GO_function GO:0004519 endonuclease activity; IEA:UniProtKB-KW. # GO_function GO:0004540 ribonuclease activity; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0030308 negative regulation of cell growth; IMP:EcoCyc. # GO_process GO:0090501 RNA phosphodiester bond hydrolysis; IDA:EcoCyc. # GOslim_function GO:0004518 nuclease activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # InterPro IPR021679 Toxin_endonuclease_YhaV # Organism YHAV_ECOLI Escherichia coli (strain K12) # PATRIC 32121676 VBIEscCol129921_3224 # PIR F65102 F65102 # Pfam PF11663 Toxin_YhaV # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHAV_ECOLI Toxin YhaV # RefSeq NP_417599 NC_000913.3 # RefSeq WP_000347273 NZ_LN832404.1 # SUBUNIT Homohexamer; forms a complex with PrlF (SohA) with stoichiometry PrlF(2)-YhaV(4), possibly as a YhaV(2)-PrlF(2)- YhaV(2) complex like the MazFE complex. This complex is seen to dimerize in solution. {ECO:0000269|PubMed 17706670}. # eggNOG ENOG4108R8Z Bacteria # eggNOG ENOG4111FPC LUCA BLAST swissprot:YHAV_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHAV_ECOLI BioCyc ECOL316407:JW3099-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3099-MONOMER BioCyc EcoCyc:G7629-MONOMER http://biocyc.org/getid?id=EcoCyc:G7629-MONOMER BioCyc MetaCyc:G7629-MONOMER http://biocyc.org/getid?id=MetaCyc:G7629-MONOMER DOI 10.1016/S0079-6603(08)00812-X http://dx.doi.org/10.1016/S0079-6603(08)00812-X DOI 10.1016/j.jmb.2007.07.016 http://dx.doi.org/10.1016/j.jmb.2007.07.016 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 3.1.-.- http://enzyme.expasy.org/EC/3.1.-.- EchoBASE EB2614 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2614 EcoGene EG12761 http://www.ecogene.org/geneInfo.php?eg_id=EG12761 EnsemblBacteria AAC76164 http://www.ensemblgenomes.org/id/AAC76164 EnsemblBacteria AAC76164 http://www.ensemblgenomes.org/id/AAC76164 EnsemblBacteria BAE77177 http://www.ensemblgenomes.org/id/BAE77177 EnsemblBacteria BAE77177 http://www.ensemblgenomes.org/id/BAE77177 EnsemblBacteria BAE77177 http://www.ensemblgenomes.org/id/BAE77177 EnsemblBacteria b3130 http://www.ensemblgenomes.org/id/b3130 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004519 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004519 GO_function GO:0004540 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004540 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0030308 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030308 GO_process GO:0090501 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090501 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 947638 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947638 HOGENOM HOG000229556 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000229556&db=HOGENOM6 InParanoid P64594 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P64594 IntEnz 3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1 InterPro IPR021679 http://www.ebi.ac.uk/interpro/entry/IPR021679 KEGG_Gene ecj:JW3099 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3099 KEGG_Gene eco:b3130 http://www.genome.jp/dbget-bin/www_bget?eco:b3130 OMA AWVNDET http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AWVNDET PSORT swissprot:YHAV_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHAV_ECOLI PSORT-B swissprot:YHAV_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHAV_ECOLI PSORT2 swissprot:YHAV_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHAV_ECOLI Pfam PF11663 http://pfam.xfam.org/family/PF11663 Phobius swissprot:YHAV_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHAV_ECOLI PhylomeDB P64594 http://phylomedb.org/?seqid=P64594 ProteinModelPortal P64594 http://www.proteinmodelportal.org/query/uniprot/P64594 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17706670 http://www.ncbi.nlm.nih.gov/pubmed/17706670 PubMed 19215780 http://www.ncbi.nlm.nih.gov/pubmed/19215780 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417599 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417599 RefSeq WP_000347273 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000347273 STRING 511145.b3130 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3130&targetmode=cogs UniProtKB YHAV_ECOLI http://www.uniprot.org/uniprot/YHAV_ECOLI UniProtKB-AC P64594 http://www.uniprot.org/uniprot/P64594 charge swissprot:YHAV_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHAV_ECOLI eggNOG ENOG4108R8Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108R8Z eggNOG ENOG4111FPC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111FPC epestfind swissprot:YHAV_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHAV_ECOLI garnier swissprot:YHAV_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHAV_ECOLI helixturnhelix swissprot:YHAV_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHAV_ECOLI hmoment swissprot:YHAV_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHAV_ECOLI iep swissprot:YHAV_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHAV_ECOLI inforesidue swissprot:YHAV_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHAV_ECOLI octanol swissprot:YHAV_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHAV_ECOLI pepcoil swissprot:YHAV_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHAV_ECOLI pepdigest swissprot:YHAV_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHAV_ECOLI pepinfo swissprot:YHAV_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHAV_ECOLI pepnet swissprot:YHAV_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHAV_ECOLI pepstats swissprot:YHAV_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHAV_ECOLI pepwheel swissprot:YHAV_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHAV_ECOLI pepwindow swissprot:YHAV_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHAV_ECOLI sigcleave swissprot:YHAV_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHAV_ECOLI ## Database ID URL or Descriptions # AltName COAA_ECOLI Pantothenic acid kinase # AltName COAA_ECOLI Rts protein # BRENDA 2.7.1.33 2026 # CATALYTIC ACTIVITY COAA_ECOLI ATP + (R)-pantothenate = ADP + (R)-4'- phosphopantothenate. # CDD cd02025 PanK # ENZYME REGULATION COAA_ECOLI Regulated by feedback inhibition by CoA and its thioesters. # EcoGene EG10922 coaA # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0004594 pantothenate kinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IDA:EcoCyc. # GO_process GO:0015937 coenzyme A biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.300 -; 1. # HAMAP MF_00215 Pantothen_kinase_1 # IntAct P0A6I3 2 # InterPro IPR004566 PanK_bact # InterPro IPR006083 PRK/URK # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00770 Pantothenate and CoA biosynthesis # Organism COAA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10285:SF7 PTHR10285:SF7; 2 # PATHWAY Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate step 1/5. # PATRIC 32123469 VBIEscCol129921_4091 # PDB 1ESM X-ray; 2.50 A; A/B/C/D=1-316 # PDB 1ESN X-ray; 2.60 A; A/B/C/D=1-316 # PDB 1SQ5 X-ray; 2.20 A; A/B/C/D=9-316 # PIR A45727 BVECRS # PIRSF PIRSF000545 Pantothenate_kin # Pfam PF00485 PRK # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName COAA_ECOLI Pantothenate kinase # RefSeq NP_418405 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA23591.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAA76838.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the prokaryotic pantothenate kinase family. {ECO 0000305}. # SUBCELLULAR LOCATION COAA_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR00554 panK_bact # UniPathway UPA00241 UER00352 # eggNOG COG1072 LUCA # eggNOG ENOG4105CS9 Bacteria BLAST swissprot:COAA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:COAA_ECOLI BioCyc ECOL316407:JW3942-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3942-MONOMER BioCyc EcoCyc:PANTOTHENATE-KIN-MONOMER http://biocyc.org/getid?id=EcoCyc:PANTOTHENATE-KIN-MONOMER BioCyc MetaCyc:PANTOTHENATE-KIN-MONOMER http://biocyc.org/getid?id=MetaCyc:PANTOTHENATE-KIN-MONOMER COG COG1072 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1072 DOI 10.1016/0378-1119(88)90189-8 http://dx.doi.org/10.1016/0378-1119(88)90189-8 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.33 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.33 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M36321 http://www.ebi.ac.uk/ena/data/view/M36321 EMBL M90071 http://www.ebi.ac.uk/ena/data/view/M90071 EMBL M90071 http://www.ebi.ac.uk/ena/data/view/M90071 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.33 http://enzyme.expasy.org/EC/2.7.1.33 EchoBASE EB0915 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0915 EcoGene EG10922 http://www.ecogene.org/geneInfo.php?eg_id=EG10922 EnsemblBacteria AAC76952 http://www.ensemblgenomes.org/id/AAC76952 EnsemblBacteria AAC76952 http://www.ensemblgenomes.org/id/AAC76952 EnsemblBacteria BAE77341 http://www.ensemblgenomes.org/id/BAE77341 EnsemblBacteria BAE77341 http://www.ensemblgenomes.org/id/BAE77341 EnsemblBacteria BAE77341 http://www.ensemblgenomes.org/id/BAE77341 EnsemblBacteria b3974 http://www.ensemblgenomes.org/id/b3974 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004594 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004594 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0015937 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015937 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948479 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948479 HAMAP MF_00215 http://hamap.expasy.org/unirule/MF_00215 HOGENOM HOG000248571 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000248571&db=HOGENOM6 InParanoid P0A6I3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6I3 IntAct P0A6I3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6I3* IntEnz 2.7.1.33 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.33 InterPro IPR004566 http://www.ebi.ac.uk/interpro/entry/IPR004566 InterPro IPR006083 http://www.ebi.ac.uk/interpro/entry/IPR006083 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3942 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3942 KEGG_Gene eco:b3974 http://www.genome.jp/dbget-bin/www_bget?eco:b3974 KEGG_Orthology KO:K00867 http://www.genome.jp/dbget-bin/www_bget?KO:K00867 KEGG_Pathway ko00770 http://www.genome.jp/kegg-bin/show_pathway?ko00770 KEGG_Reaction rn:R02971 http://www.genome.jp/dbget-bin/www_bget?rn:R02971 KEGG_Reaction rn:R03018 http://www.genome.jp/dbget-bin/www_bget?rn:R03018 KEGG_Reaction rn:R04391 http://www.genome.jp/dbget-bin/www_bget?rn:R04391 OMA LMQRKGF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LMQRKGF PANTHER PTHR10285:SF7 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10285:SF7 PDB 1ESM http://www.ebi.ac.uk/pdbe-srv/view/entry/1ESM PDB 1ESN http://www.ebi.ac.uk/pdbe-srv/view/entry/1ESN PDB 1SQ5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1SQ5 PDBsum 1ESM http://www.ebi.ac.uk/pdbsum/1ESM PDBsum 1ESN http://www.ebi.ac.uk/pdbsum/1ESN PDBsum 1SQ5 http://www.ebi.ac.uk/pdbsum/1SQ5 PSORT swissprot:COAA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:COAA_ECOLI PSORT-B swissprot:COAA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:COAA_ECOLI PSORT2 swissprot:COAA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:COAA_ECOLI Pfam PF00485 http://pfam.xfam.org/family/PF00485 Phobius swissprot:COAA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:COAA_ECOLI PhylomeDB P0A6I3 http://phylomedb.org/?seqid=P0A6I3 ProteinModelPortal P0A6I3 http://www.proteinmodelportal.org/query/uniprot/P0A6I3 PubMed 1311303 http://www.ncbi.nlm.nih.gov/pubmed/1311303 PubMed 1328157 http://www.ncbi.nlm.nih.gov/pubmed/1328157 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3073109 http://www.ncbi.nlm.nih.gov/pubmed/3073109 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418405 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418405 SMR P0A6I3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6I3 STRING 511145.b3974 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3974&targetmode=cogs STRING COG1072 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1072&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR00554 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00554 UniProtKB COAA_ECOLI http://www.uniprot.org/uniprot/COAA_ECOLI UniProtKB-AC P0A6I3 http://www.uniprot.org/uniprot/P0A6I3 charge swissprot:COAA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:COAA_ECOLI eggNOG COG1072 http://eggnogapi.embl.de/nog_data/html/tree/COG1072 eggNOG ENOG4105CS9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CS9 epestfind swissprot:COAA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:COAA_ECOLI garnier swissprot:COAA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:COAA_ECOLI helixturnhelix swissprot:COAA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:COAA_ECOLI hmoment swissprot:COAA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:COAA_ECOLI iep swissprot:COAA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:COAA_ECOLI inforesidue swissprot:COAA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:COAA_ECOLI octanol swissprot:COAA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:COAA_ECOLI pepcoil swissprot:COAA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:COAA_ECOLI pepdigest swissprot:COAA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:COAA_ECOLI pepinfo swissprot:COAA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:COAA_ECOLI pepnet swissprot:COAA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:COAA_ECOLI pepstats swissprot:COAA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:COAA_ECOLI pepwheel swissprot:COAA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:COAA_ECOLI pepwindow swissprot:COAA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:COAA_ECOLI sigcleave swissprot:COAA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:COAA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260822 234 # EcoGene EG10891 rpmG # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0022625 cytosolic large ribosomal subunit; IDA:EcoCyc. # GO_function GO:0000049 tRNA binding; IEA:UniProtKB-KW. # GO_function GO:0003735 structural constituent of ribosome; IBA:GO_Central. # GO_process GO:0006412 translation; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_process GO:0006412 translation # HAMAP MF_00294 Ribosomal_L33 # IntAct P0A7N9 53 # InterPro IPR001705 Ribosomal_L33 # InterPro IPR011332 Ribosomal_zn-bd # InterPro IPR018264 Ribosomal_L33_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=6254.1; Method=MALDI; Range=2-55; Evidence={ECO:0000269|PubMed 10094780}; # MISCELLANEOUS RL33_ECOLI Surface exposed on the 50S subunit. # Organism RL33_ECOLI Escherichia coli (strain K12) # PATRIC 32122759 VBIEscCol129921_3756 # PDB 2J28 EM; 8.00 A; 1=2-55 # PDB 2RDO EM; 9.10 A; 1=2-55 # PDB 3BBX EM; 10.00 A; 1=2-55 # PDB 3J5L EM; 6.60 A; 1=4-53 # PDB 3J5S EM; 7.50 A; H=4-53 # PDB 3J7Z EM; 3.90 A; 1=1-55 # PDB 3J9Y EM; 3.90 A; 1=1-55 # PDB 3J9Z EM; 3.60 A; L2=2-55 # PDB 3JA1 EM; 3.60 A; L4=2-55 # PDB 3JBU EM; 3.64 A; 4=1-55 # PDB 3JBV EM; 3.32 A; 4=1-55 # PDB 3JCD EM; 3.70 A; 1=1-55 # PDB 3JCE EM; 3.20 A; 1=1-55 # PDB 3JCJ EM; 3.70 A; a=1-55 # PDB 3JCN EM; 4.60 A; 1=1-55 # PDB 4CSU EM; 5.50 A; 4=2-55 # PDB 4U1U X-ray; 2.95 A; B1/D1=4-53 # PDB 4U1V X-ray; 3.00 A; B1/D1=4-53 # PDB 4U20 X-ray; 2.90 A; B1/D1=4-53 # PDB 4U24 X-ray; 2.90 A; B1/D1=4-53 # PDB 4U25 X-ray; 2.90 A; B1/D1=4-53 # PDB 4U26 X-ray; 2.80 A; B1/D1=4-53 # PDB 4U27 X-ray; 2.80 A; B1/D1=4-53 # PDB 4UY8 EM; 3.80 A; 1=4-53 # PDB 4V47 EM; 12.30 A; A1=2-55 # PDB 4V48 EM; 11.50 A; A1=2-55 # PDB 4V4H X-ray; 3.46 A; B1/D1=1-55 # PDB 4V4Q X-ray; 3.46 A; B1/D1=2-55 # PDB 4V4V EM; 15.00 A; B1=2-53 # PDB 4V4W EM; 15.00 A; B1=2-53 # PDB 4V50 X-ray; 3.22 A; B1/D1=2-55 # PDB 4V52 X-ray; 3.21 A; B1/D1=2-55 # PDB 4V53 X-ray; 3.54 A; B1/D1=2-55 # PDB 4V54 X-ray; 3.30 A; B1/D1=2-55 # PDB 4V55 X-ray; 4.00 A; B1/D1=2-55 # PDB 4V56 X-ray; 3.93 A; B1/D1=2-55 # PDB 4V57 X-ray; 3.50 A; B1/D1=2-55 # PDB 4V5B X-ray; 3.74 A; A1/C1=2-55 # PDB 4V5H EM; 5.80 A; B4=4-53 # PDB 4V5Y X-ray; 4.45 A; B1/D1=2-55 # PDB 4V64 X-ray; 3.50 A; B1/D1=2-55 # PDB 4V65 EM; 9.00 A; BU=2-55 # PDB 4V66 EM; 9.00 A; BU=2-55 # PDB 4V69 EM; 6.70 A; B1=4-53 # PDB 4V6C X-ray; 3.19 A; B1/D1=1-55 # PDB 4V6D X-ray; 3.81 A; B1/D1=1-55 # PDB 4V6E X-ray; 3.71 A; B1/D1=1-55 # PDB 4V6K EM; 8.25 A; Ad=1-55 # PDB 4V6L EM; 13.20 A; Bd=1-55 # PDB 4V6M EM; 7.10 A; B1=2-55 # PDB 4V6N EM; 12.10 A; A4=2-55 # PDB 4V6O EM; 14.70 A; B4=2-55 # PDB 4V6P EM; 13.50 A; B4=2-55 # PDB 4V6Q EM; 11.50 A; B4=2-55 # PDB 4V6R EM; 11.50 A; B4=2-55 # PDB 4V6S EM; 13.10 A; A4=2-55 # PDB 4V6T EM; 8.30 A; B1=4-53 # PDB 4V6V EM; 9.80 A; B6=2-55 # PDB 4V6Y EM; 12.00 A; B1=4-53 # PDB 4V6Z EM; 12.00 A; B1=4-53 # PDB 4V70 EM; 17.00 A; B1=4-53 # PDB 4V71 EM; 20.00 A; B1=4-53 # PDB 4V72 EM; 13.00 A; B1=4-53 # PDB 4V73 EM; 15.00 A; B1=4-53 # PDB 4V74 EM; 17.00 A; B1=4-53 # PDB 4V75 EM; 12.00 A; B1=4-53 # PDB 4V76 EM; 17.00 A; B1=4-53 # PDB 4V77 EM; 17.00 A; B1=4-53 # PDB 4V78 EM; 20.00 A; B1=4-53 # PDB 4V79 EM; 15.00 A; B1=4-53 # PDB 4V7A EM; 9.00 A; B1=4-53 # PDB 4V7B EM; 6.80 A; B1=1-55 # PDB 4V7C EM; 7.60 A; B4=2-55 # PDB 4V7D EM; 7.60 A; A5=2-55 # PDB 4V7I EM; 9.60 A; A1=1-55 # PDB 4V7S X-ray; 3.25 A; B1/D1=4-53 # PDB 4V7T X-ray; 3.19 A; B1/D1=4-53 # PDB 4V7U X-ray; 3.10 A; B1/D1=4-53 # PDB 4V7V X-ray; 3.29 A; B1/D1=4-53 # PDB 4V85 X-ray; 3.20 A; 5=1-55 # PDB 4V89 X-ray; 3.70 A; B5=1-55 # PDB 4V9C X-ray; 3.30 A; B1/D1=1-55 # PDB 4V9D X-ray; 3.00 A; C1/D1=4-53 # PDB 4V9O X-ray; 2.90 A; A1/C1/E1/G1=1-55 # PDB 4V9P X-ray; 2.90 A; A1/C1/E1/G1=1-55 # PDB 4WF1 X-ray; 3.09 A; B1/D1=4-53 # PDB 4WOI X-ray; 3.00 A; B1/C1=1-55 # PDB 4WWW X-ray; 3.10 A; R1/Y1=4-53 # PDB 4YBB X-ray; 2.10 A; C2/D2=4-54 # PDB 5ADY EM; 4.50 A; 1=1-55 # PDB 5AFI EM; 2.90 A; 1=1-55 # PDB 5AKA EM; 5.70 A; 1=2-55 # PDB 5GAD EM; 3.70 A; c=1-55 # PDB 5GAE EM; 3.33 A; c=1-55 # PDB 5GAF EM; 4.30 A; c=4-54 # PDB 5GAG EM; 3.80 A; c=1-55 # PDB 5GAH EM; 3.80 A; c=1-55 # PDB 5IQR EM; 3.00 A; c=1-55 # PDB 5IT8 X-ray; 3.12 A; C2/D2=4-54 # PDB 5J5B X-ray; 2.80 A; C2/D2=4-54 # PDB 5J7L X-ray; 3.00 A; C2/D2=4-54 # PDB 5J88 X-ray; 3.32 A; C2/D2=4-54 # PDB 5J8A X-ray; 3.10 A; C2/D2=4-54 # PDB 5J91 X-ray; 2.96 A; C2/D2=4-54 # PDB 5JC9 X-ray; 3.03 A; C2/D2=4-54 # PDB 5JTE EM; 3.60 A; B1=1-55 # PDB 5JU8 EM; 3.60 A; B1=1-55 # PDB 5KCR EM; 3.60 A; 16=1-55 # PDB 5KCS EM; 3.90 A; 16=1-55 # PDB 5KPS EM; 3.90 A; 3=1-55 # PDB 5KPV EM; 4.10 A; 2=1-55 # PDB 5KPW EM; 3.90 A; 2=1-55 # PDB 5KPX EM; 3.90 A; 2=1-55 # PDB 5L3P EM; 3.70 A; 6=1-55 # PIR S42444 R5EC33 # PROSITE PS00582 RIBOSOMAL_L33 # Pfam PF00471 Ribosomal_L33 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RL33_ECOLI 50S ribosomal protein L33 # RefSeq NP_418093 NC_000913.3 # RefSeq WP_001051798 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein L33P family. {ECO 0000305}. # SUBUNIT Part of the 50S ribosomal subunit. Cross-links to the P and E site tRNAs. {ECO:0000269|PubMed 8524654}. # SUPFAM SSF57829 SSF57829 # TIGRFAMs TIGR01023 rpmG_bact # eggNOG COG0267 LUCA BLAST swissprot:RL33_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RL33_ECOLI BioCyc ECOL316407:JW3611-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3611-MONOMER BioCyc EcoCyc:EG10891-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10891-MONOMER BioCyc MetaCyc:EG10891-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10891-MONOMER COG COG0267 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0267 DIP DIP-35968N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35968N DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1016/0014-5793(76)80417-6 http://dx.doi.org/10.1016/0014-5793(76)80417-6 DOI 10.1016/S0092-8674(03)00427-6 http://dx.doi.org/10.1016/S0092-8674(03)00427-6 DOI 10.1016/j.celrep.2014.09.011 http://dx.doi.org/10.1016/j.celrep.2014.09.011 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.22.4635 http://dx.doi.org/10.1093/nar/23.22.4635 DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pbio.1001866 http://dx.doi.org/10.1371/journal.pbio.1001866 DisProt DP00143 http://www.disprot.org/protein.php?id=DP00143 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01677 http://www.ebi.ac.uk/ena/data/view/J01677 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0884 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0884 EcoGene EG10891 http://www.ecogene.org/geneInfo.php?eg_id=EG10891 EnsemblBacteria AAC76660 http://www.ensemblgenomes.org/id/AAC76660 EnsemblBacteria AAC76660 http://www.ensemblgenomes.org/id/AAC76660 EnsemblBacteria BAE77656 http://www.ensemblgenomes.org/id/BAE77656 EnsemblBacteria BAE77656 http://www.ensemblgenomes.org/id/BAE77656 EnsemblBacteria BAE77656 http://www.ensemblgenomes.org/id/BAE77656 EnsemblBacteria b3636 http://www.ensemblgenomes.org/id/b3636 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0022625 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022625 GO_function GO:0000049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000049 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GeneID 8913847 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8913847 GeneID 946318 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946318 HAMAP MF_00294 http://hamap.expasy.org/unirule/MF_00294 HOGENOM HOG000004839 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000004839&db=HOGENOM6 InParanoid P0A7N9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7N9 IntAct P0A7N9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7N9* InterPro IPR001705 http://www.ebi.ac.uk/interpro/entry/IPR001705 InterPro IPR011332 http://www.ebi.ac.uk/interpro/entry/IPR011332 InterPro IPR018264 http://www.ebi.ac.uk/interpro/entry/IPR018264 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW3611 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3611 KEGG_Gene eco:b3636 http://www.genome.jp/dbget-bin/www_bget?eco:b3636 KEGG_Orthology KO:K02913 http://www.genome.jp/dbget-bin/www_bget?KO:K02913 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 MINT MINT-1234559 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1234559 OMA ARKHVLY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ARKHVLY PDB 2J28 http://www.ebi.ac.uk/pdbe-srv/view/entry/2J28 PDB 2RDO http://www.ebi.ac.uk/pdbe-srv/view/entry/2RDO PDB 3BBX http://www.ebi.ac.uk/pdbe-srv/view/entry/3BBX PDB 3J5L http://www.ebi.ac.uk/pdbe-srv/view/entry/3J5L PDB 3J5S http://www.ebi.ac.uk/pdbe-srv/view/entry/3J5S PDB 3J7Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J7Z PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 4CSU http://www.ebi.ac.uk/pdbe-srv/view/entry/4CSU PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4UY8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4UY8 PDB 4V47 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V47 PDB 4V48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V48 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5ADY http://www.ebi.ac.uk/pdbe-srv/view/entry/5ADY PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5AKA http://www.ebi.ac.uk/pdbe-srv/view/entry/5AKA PDB 5GAD http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAD PDB 5GAE http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAE PDB 5GAF http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAF PDB 5GAG http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAG PDB 5GAH http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAH PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 2J28 http://www.ebi.ac.uk/pdbsum/2J28 PDBsum 2RDO http://www.ebi.ac.uk/pdbsum/2RDO PDBsum 3BBX http://www.ebi.ac.uk/pdbsum/3BBX PDBsum 3J5L http://www.ebi.ac.uk/pdbsum/3J5L PDBsum 3J5S http://www.ebi.ac.uk/pdbsum/3J5S PDBsum 3J7Z http://www.ebi.ac.uk/pdbsum/3J7Z PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 4CSU http://www.ebi.ac.uk/pdbsum/4CSU PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4UY8 http://www.ebi.ac.uk/pdbsum/4UY8 PDBsum 4V47 http://www.ebi.ac.uk/pdbsum/4V47 PDBsum 4V48 http://www.ebi.ac.uk/pdbsum/4V48 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5ADY http://www.ebi.ac.uk/pdbsum/5ADY PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5AKA http://www.ebi.ac.uk/pdbsum/5AKA PDBsum 5GAD http://www.ebi.ac.uk/pdbsum/5GAD PDBsum 5GAE http://www.ebi.ac.uk/pdbsum/5GAE PDBsum 5GAF http://www.ebi.ac.uk/pdbsum/5GAF PDBsum 5GAG http://www.ebi.ac.uk/pdbsum/5GAG PDBsum 5GAH http://www.ebi.ac.uk/pdbsum/5GAH PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PROSITE PS00582 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00582 PSORT swissprot:RL33_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RL33_ECOLI PSORT-B swissprot:RL33_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RL33_ECOLI PSORT2 swissprot:RL33_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RL33_ECOLI Pfam PF00471 http://pfam.xfam.org/family/PF00471 Phobius swissprot:RL33_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RL33_ECOLI PhylomeDB P0A7N9 http://phylomedb.org/?seqid=P0A7N9 ProteinModelPortal P0A7N9 http://www.proteinmodelportal.org/query/uniprot/P0A7N9 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 12809609 http://www.ncbi.nlm.nih.gov/pubmed/12809609 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 24844575 http://www.ncbi.nlm.nih.gov/pubmed/24844575 PubMed 25310980 http://www.ncbi.nlm.nih.gov/pubmed/25310980 PubMed 7035835 http://www.ncbi.nlm.nih.gov/pubmed/7035835 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 786732 http://www.ncbi.nlm.nih.gov/pubmed/786732 PubMed 8524654 http://www.ncbi.nlm.nih.gov/pubmed/8524654 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418093 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418093 RefSeq WP_001051798 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001051798 SMR P0A7N9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7N9 STRING 511145.b3636 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3636&targetmode=cogs STRING COG0267 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0267&targetmode=cogs SUPFAM SSF57829 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF57829 TIGRFAMs TIGR01023 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01023 UniProtKB RL33_ECOLI http://www.uniprot.org/uniprot/RL33_ECOLI UniProtKB-AC P0A7N9 http://www.uniprot.org/uniprot/P0A7N9 charge swissprot:RL33_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RL33_ECOLI eggNOG COG0267 http://eggnogapi.embl.de/nog_data/html/tree/COG0267 epestfind swissprot:RL33_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RL33_ECOLI garnier swissprot:RL33_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RL33_ECOLI helixturnhelix swissprot:RL33_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RL33_ECOLI hmoment swissprot:RL33_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RL33_ECOLI iep swissprot:RL33_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RL33_ECOLI inforesidue swissprot:RL33_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RL33_ECOLI octanol swissprot:RL33_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RL33_ECOLI pepcoil swissprot:RL33_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RL33_ECOLI pepdigest swissprot:RL33_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RL33_ECOLI pepinfo swissprot:RL33_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RL33_ECOLI pepnet swissprot:RL33_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RL33_ECOLI pepstats swissprot:RL33_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RL33_ECOLI pepwheel swissprot:RL33_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RL33_ECOLI pepwindow swissprot:RL33_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RL33_ECOLI sigcleave swissprot:RL33_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RL33_ECOLI ## Database ID URL or Descriptions # AltName INSB1_ECOLI IS1a # EcoGene EG40002 insB1 # FUNCTION INSB1_ECOLI Absolutely required for transposition of IS1. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # InterPro IPR005063 Transposase_27 # Organism INSB1_ECOLI Escherichia coli (strain K12) # PIR JN0135 JN0135 # Pfam PF03400 DDE_Tnp_IS1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSB1_ECOLI Insertion element IS1 1 protein InsB # RefSeq NP_414562 NC_000913.3 # RefSeq NP_416407 NC_000913.3 # RefSeq NP_417902 NC_000913.3 # RefSeq WP_001119362 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA96229.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the transposase 27 family. {ECO 0000305}. # eggNOG COG1662 LUCA BLAST swissprot:INSB1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSB1_ECOLI BioCyc EcoCyc:G7762-MONOMER http://biocyc.org/getid?id=EcoCyc:G7762-MONOMER COG COG1662 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1662 DOI 10.1007/BF00271673 http://dx.doi.org/10.1007/BF00271673 DOI 10.1016/0378-1119(91)90096-T http://dx.doi.org/10.1016/0378-1119(91)90096-T DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01729 http://www.ebi.ac.uk/ena/data/view/J01729 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X52534 http://www.ebi.ac.uk/ena/data/view/X52534 EchoBASE EB4700 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4700 EcoGene EG40002 http://www.ecogene.org/geneInfo.php?eg_id=EG40002 EnsemblBacteria AAC73132 http://www.ensemblgenomes.org/id/AAC73132 EnsemblBacteria AAC73132 http://www.ensemblgenomes.org/id/AAC73132 EnsemblBacteria BAE76033 http://www.ensemblgenomes.org/id/BAE76033 EnsemblBacteria BAE76033 http://www.ensemblgenomes.org/id/BAE76033 EnsemblBacteria BAE76033 http://www.ensemblgenomes.org/id/BAE76033 EnsemblBacteria b0021 http://www.ensemblgenomes.org/id/b0021 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GeneID 24944608 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24944608 GeneID 944743 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944743 GeneID 945867 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945867 GeneID 947949 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947949 HOGENOM HOG000036821 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000036821&db=HOGENOM6 InParanoid P0CF25 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CF25 InterPro IPR005063 http://www.ebi.ac.uk/interpro/entry/IPR005063 KEGG_Gene ecj:JW0020 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0020 KEGG_Gene eco:b0021 http://www.genome.jp/dbget-bin/www_bget?eco:b0021 KEGG_Gene eco:b1893 http://www.genome.jp/dbget-bin/www_bget?eco:b1893 KEGG_Gene eco:b3445 http://www.genome.jp/dbget-bin/www_bget?eco:b3445 KEGG_Orthology KO:K07480 http://www.genome.jp/dbget-bin/www_bget?KO:K07480 PSORT swissprot:INSB1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSB1_ECOLI PSORT-B swissprot:INSB1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSB1_ECOLI PSORT2 swissprot:INSB1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSB1_ECOLI Pfam PF03400 http://pfam.xfam.org/family/PF03400 Phobius swissprot:INSB1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSB1_ECOLI PhylomeDB P0CF25 http://phylomedb.org/?seqid=P0CF25 ProteinModelPortal P0CF25 http://www.proteinmodelportal.org/query/uniprot/P0CF25 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1849492 http://www.ncbi.nlm.nih.gov/pubmed/1849492 PubMed 375010 http://www.ncbi.nlm.nih.gov/pubmed/375010 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414562 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414562 RefSeq NP_416407 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416407 RefSeq NP_417902 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417902 RefSeq WP_001119362 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001119362 STRING 511145.b3445 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3445&targetmode=cogs STRING COG1662 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1662&targetmode=cogs UniProtKB INSB1_ECOLI http://www.uniprot.org/uniprot/INSB1_ECOLI UniProtKB-AC P0CF25 http://www.uniprot.org/uniprot/P0CF25 charge swissprot:INSB1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSB1_ECOLI eggNOG COG1662 http://eggnogapi.embl.de/nog_data/html/tree/COG1662 epestfind swissprot:INSB1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSB1_ECOLI garnier swissprot:INSB1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSB1_ECOLI helixturnhelix swissprot:INSB1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSB1_ECOLI hmoment swissprot:INSB1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSB1_ECOLI iep swissprot:INSB1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSB1_ECOLI inforesidue swissprot:INSB1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSB1_ECOLI octanol swissprot:INSB1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSB1_ECOLI pepcoil swissprot:INSB1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSB1_ECOLI pepdigest swissprot:INSB1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSB1_ECOLI pepinfo swissprot:INSB1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSB1_ECOLI pepnet swissprot:INSB1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSB1_ECOLI pepstats swissprot:INSB1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSB1_ECOLI pepwheel swissprot:INSB1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSB1_ECOLI pepwindow swissprot:INSB1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSB1_ECOLI sigcleave swissprot:INSB1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSB1_ECOLI ## Database ID URL or Descriptions # BioGrid 4261204 137 # EcoGene EG13323 ybiR # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IBA:GO_Central. # GO_function GO:0005215 transporter activity; IBA:GO_Central. # GO_process GO:0098656 anion transmembrane transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0055085 transmembrane transport # InterPro IPR004680 Cit_transptr-like_dom # Organism YBIR_ECOLI Escherichia coli (strain K12) # PATRIC 32116839 VBIEscCol129921_0845 # PIR B64819 B64819 # Pfam PF03600 CitMHS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBIR_ECOLI Inner membrane protein YbiR # RefSeq NP_415339 NC_000913.3 # RefSeq WP_000056457 NZ_LN832404.1 # SIMILARITY Belongs to the CitM (TC 2.A.11) transporter family. {ECO 0000305}. # SUBCELLULAR LOCATION YBIR_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.45.2 the arsenite-antimonite (arsb) efflux family # eggNOG COG0471 LUCA # eggNOG ENOG4105F4P Bacteria BLAST swissprot:YBIR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBIR_ECOLI BioCyc ECOL316407:JW0802-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0802-MONOMER BioCyc EcoCyc:G6421-MONOMER http://biocyc.org/getid?id=EcoCyc:G6421-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3107 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3107 EcoGene EG13323 http://www.ecogene.org/geneInfo.php?eg_id=EG13323 EnsemblBacteria AAC73905 http://www.ensemblgenomes.org/id/AAC73905 EnsemblBacteria AAC73905 http://www.ensemblgenomes.org/id/AAC73905 EnsemblBacteria BAA35499 http://www.ensemblgenomes.org/id/BAA35499 EnsemblBacteria BAA35499 http://www.ensemblgenomes.org/id/BAA35499 EnsemblBacteria BAA35499 http://www.ensemblgenomes.org/id/BAA35499 EnsemblBacteria b0818 http://www.ensemblgenomes.org/id/b0818 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_process GO:0098656 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098656 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 945438 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945438 HOGENOM HOG000253850 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000253850&db=HOGENOM6 InParanoid P75788 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75788 InterPro IPR004680 http://www.ebi.ac.uk/interpro/entry/IPR004680 KEGG_Gene ecj:JW0802 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0802 KEGG_Gene eco:b0818 http://www.genome.jp/dbget-bin/www_bget?eco:b0818 OMA DAIDWHT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DAIDWHT PSORT swissprot:YBIR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBIR_ECOLI PSORT-B swissprot:YBIR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBIR_ECOLI PSORT2 swissprot:YBIR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBIR_ECOLI Pfam PF03600 http://pfam.xfam.org/family/PF03600 Phobius swissprot:YBIR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBIR_ECOLI PhylomeDB P75788 http://phylomedb.org/?seqid=P75788 ProteinModelPortal P75788 http://www.proteinmodelportal.org/query/uniprot/P75788 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415339 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415339 RefSeq WP_000056457 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000056457 STRING 511145.b0818 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0818&targetmode=cogs TCDB 2.A.45.2 http://www.tcdb.org/search/result.php?tc=2.A.45.2 UniProtKB YBIR_ECOLI http://www.uniprot.org/uniprot/YBIR_ECOLI UniProtKB-AC P75788 http://www.uniprot.org/uniprot/P75788 charge swissprot:YBIR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBIR_ECOLI eggNOG COG0471 http://eggnogapi.embl.de/nog_data/html/tree/COG0471 eggNOG ENOG4105F4P http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F4P epestfind swissprot:YBIR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBIR_ECOLI garnier swissprot:YBIR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBIR_ECOLI helixturnhelix swissprot:YBIR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBIR_ECOLI hmoment swissprot:YBIR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBIR_ECOLI iep swissprot:YBIR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBIR_ECOLI inforesidue swissprot:YBIR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBIR_ECOLI octanol swissprot:YBIR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBIR_ECOLI pepcoil swissprot:YBIR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBIR_ECOLI pepdigest swissprot:YBIR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBIR_ECOLI pepinfo swissprot:YBIR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBIR_ECOLI pepnet swissprot:YBIR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBIR_ECOLI pepstats swissprot:YBIR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBIR_ECOLI pepwheel swissprot:YBIR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBIR_ECOLI pepwindow swissprot:YBIR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBIR_ECOLI sigcleave swissprot:YBIR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBIR_ECOLI ## Database ID URL or Descriptions # AltName Murein lyase F {ECO:0000255|HAMAP-Rule MF_02016} # BIOPHYSICOCHEMICAL PROPERTIES pH dependence: Optimum pH is 6.5-7.0. {ECO 0000269|PubMed:18234673}; # BioGrid 4259207 7 # CATALYTIC ACTIVITY Exolytic cleavage of the (1->4)-beta- glycosidic linkage between N-acetylmuramic acid (MurNAc) and N- acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue. {ECO:0000255|HAMAP-Rule MF_02016}. # DOMAIN MLTF_ECOLI The N-terminal domain does not have lytic activity and probably modulates enzymatic activity. The C-terminal domain is the catalytic active domain. # EcoGene EG11373 yfhD # FUNCTION MLTF_ECOLI Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_function GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds; IDA:EcoCyc. # GO_function GO:0008933 lytic transglycosylase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0052762 gellan lyase activity; IEA:UniProtKB-EC. # GO_function GO:0052764 exo-oligoalginate lyase activity; IEA:UniProtKB-EC. # GO_process GO:0009254 peptidoglycan turnover; IDA:EcoCyc. # GO_process GO:0016998 cell wall macromolecule catabolic process; IEA:UniProtKB-HAMAP. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0071554 cell wall organization or biogenesis # HAMAP MF_02016 MltF # InterPro IPR000189 Transglyc_AS # InterPro IPR001638 Solute-binding_3/MltF_N # InterPro IPR008258 Transglycosylase_SLT_dom_1 # InterPro IPR023346 Lysozyme-like_dom # InterPro IPR023703 MltF # Organism MLTF_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21666:SF215 PTHR21666:SF215 # PATRIC 32120515 VBIEscCol129921_2660 # PIR E65033 E65033 # PROSITE PS00922 TRANSGLYCOSYLASE # Pfam PF00497 SBP_bac_3 # Pfam PF01464 SLT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Membrane-bound lytic murein transglycosylase F {ECO:0000255|HAMAP-Rule MF_02016} # RefSeq NP_417053 NC_000913.3 # RefSeq WP_000734212 NZ_LN832404.1 # SEQUENCE CAUTION MLTF_ECOLI Sequence=AAA79820.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=BAA10908.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=BAA10908.1; Type=Frameshift; Positions=478; Evidence={ECO 0000305}; Sequence=BAE76734.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=CAA51065.1; Type=Frameshift; Positions=Several; Evidence={ECO 0000305}; # SIMILARITY In the C-terminal section; belongs to the transglycosylase Slt family. {ECO:0000255|HAMAP-Rule MF_02016}. # SIMILARITY In the N-terminal section; belongs to the bacterial solute-binding protein 3 family. {ECO:0000255|HAMAP- Rule MF_02016}. # SMART SM00062 PBPb # SUBCELLULAR LOCATION MLTF_ECOLI Cell outer membrane {ECO 0000255|HAMAP- Rule MF_02016, ECO 0000269|PubMed 18234673}; Peripheral membrane protein {ECO 0000255|HAMAP-Rule MF_02016, ECO 0000269|PubMed 18234673}. Note=Attached to the inner leaflet of the outer membrane. # SUPFAM SSF53955 SSF53955; 2 # eggNOG COG4623 LUCA # eggNOG ENOG4105CHQ Bacteria BLAST swissprot:MLTF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MLTF_ECOLI BioCyc ECOL316407:JW2542-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2542-MONOMER BioCyc EcoCyc:EG11373-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11373-MONOMER BioCyc MetaCyc:EG11373-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11373-MONOMER DOI 10.1016/0968-0004(94)90201-1 http://dx.doi.org/10.1016/0968-0004(94)90201-1 DOI 10.1016/j.biocel.2007.03.018 http://dx.doi.org/10.1016/j.biocel.2007.03.018 DOI 10.1021/bi00432a017 http://dx.doi.org/10.1021/bi00432a017 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M710135200 http://dx.doi.org/10.1074/jbc.M710135200 DOI 10.1111/j.1365-2958.1992.tb01540.x http://dx.doi.org/10.1111/j.1365-2958.1992.tb01540.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.2.n1 {ECO:0000255|HAMAP-Rule:MF_02016} http://www.genome.jp/dbget-bin/www_bget?EC:4.2.2.n1 {ECO:0000255|HAMAP-Rule:MF_02016} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D64044 http://www.ebi.ac.uk/ena/data/view/D64044 EMBL M19501 http://www.ebi.ac.uk/ena/data/view/M19501 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36841 http://www.ebi.ac.uk/ena/data/view/U36841 EMBL X72336 http://www.ebi.ac.uk/ena/data/view/X72336 ENZYME 4.2.2.n1 {ECO:0000255|HAMAP-Rule:MF_02016} http://enzyme.expasy.org/EC/4.2.2.n1 {ECO:0000255|HAMAP-Rule:MF_02016} EchoBASE EB1347 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1347 EcoGene EG11373 http://www.ecogene.org/geneInfo.php?eg_id=EG11373 EnsemblBacteria AAC75611 http://www.ensemblgenomes.org/id/AAC75611 EnsemblBacteria AAC75611 http://www.ensemblgenomes.org/id/AAC75611 EnsemblBacteria BAE76734 http://www.ensemblgenomes.org/id/BAE76734 EnsemblBacteria BAE76734 http://www.ensemblgenomes.org/id/BAE76734 EnsemblBacteria BAE76734 http://www.ensemblgenomes.org/id/BAE76734 EnsemblBacteria b2558 http://www.ensemblgenomes.org/id/b2558 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_function GO:0004553 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004553 GO_function GO:0008933 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008933 GO_function GO:0052762 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052762 GO_function GO:0052764 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052764 GO_process GO:0009254 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009254 GO_process GO:0016998 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016998 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 GeneID 947028 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947028 HAMAP MF_02016 http://hamap.expasy.org/unirule/MF_02016 HOGENOM HOG000218316 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218316&db=HOGENOM6 InParanoid P0AGC5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGC5 IntEnz 4.2.2.n1 {ECO:0000255|HAMAP-Rule:MF_02016} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.2.n1 {ECO:0000255|HAMAP-Rule:MF_02016} InterPro IPR000189 http://www.ebi.ac.uk/interpro/entry/IPR000189 InterPro IPR001638 http://www.ebi.ac.uk/interpro/entry/IPR001638 InterPro IPR008258 http://www.ebi.ac.uk/interpro/entry/IPR008258 InterPro IPR023346 http://www.ebi.ac.uk/interpro/entry/IPR023346 InterPro IPR023703 http://www.ebi.ac.uk/interpro/entry/IPR023703 KEGG_Gene ecj:JW2542 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2542 KEGG_Gene eco:b2558 http://www.genome.jp/dbget-bin/www_bget?eco:b2558 OMA KYGYARG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KYGYARG PANTHER PTHR21666:SF215 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21666:SF215 PROSITE PS00922 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00922 PSORT swissprot:MLTF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MLTF_ECOLI PSORT-B swissprot:MLTF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MLTF_ECOLI PSORT2 swissprot:MLTF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MLTF_ECOLI Pfam PF00497 http://pfam.xfam.org/family/PF00497 Pfam PF01464 http://pfam.xfam.org/family/PF01464 Phobius swissprot:MLTF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MLTF_ECOLI PhylomeDB P0AGC5 http://phylomedb.org/?seqid=P0AGC5 ProteinModelPortal P0AGC5 http://www.proteinmodelportal.org/query/uniprot/P0AGC5 PubMed 1602968 http://www.ncbi.nlm.nih.gov/pubmed/1602968 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17468031 http://www.ncbi.nlm.nih.gov/pubmed/17468031 PubMed 18234673 http://www.ncbi.nlm.nih.gov/pubmed/18234673 PubMed 2659070 http://www.ncbi.nlm.nih.gov/pubmed/2659070 PubMed 8203016 http://www.ncbi.nlm.nih.gov/pubmed/8203016 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417053 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417053 RefSeq WP_000734212 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000734212 SMART SM00062 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00062 SMR P0AGC5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AGC5 STRING 511145.b2558 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2558&targetmode=cogs SUPFAM SSF53955 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53955 UniProtKB MLTF_ECOLI http://www.uniprot.org/uniprot/MLTF_ECOLI UniProtKB-AC P0AGC5 http://www.uniprot.org/uniprot/P0AGC5 charge swissprot:MLTF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MLTF_ECOLI eggNOG COG4623 http://eggnogapi.embl.de/nog_data/html/tree/COG4623 eggNOG ENOG4105CHQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CHQ epestfind swissprot:MLTF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MLTF_ECOLI garnier swissprot:MLTF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MLTF_ECOLI helixturnhelix swissprot:MLTF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MLTF_ECOLI hmoment swissprot:MLTF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MLTF_ECOLI iep swissprot:MLTF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MLTF_ECOLI inforesidue swissprot:MLTF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MLTF_ECOLI octanol swissprot:MLTF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MLTF_ECOLI pepcoil swissprot:MLTF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MLTF_ECOLI pepdigest swissprot:MLTF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MLTF_ECOLI pepinfo swissprot:MLTF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MLTF_ECOLI pepnet swissprot:MLTF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MLTF_ECOLI pepstats swissprot:MLTF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MLTF_ECOLI pepwheel swissprot:MLTF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MLTF_ECOLI pepwindow swissprot:MLTF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MLTF_ECOLI sigcleave swissprot:MLTF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MLTF_ECOLI ## Database ID URL or Descriptions # BioGrid 4260605 11 # EcoGene EG13462 yphA # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR032808 DoxX # Organism YPHA_ECOLI Escherichia coli (strain K12) # PATRIC 32120483 VBIEscCol129921_2644 # PIR F65031 F65031 # Pfam PF07681 DoxX # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YPHA_ECOLI Inner membrane protein YphA # RefSeq NP_417038 NC_000913.3 # RefSeq WP_001094726 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA16446.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA71953.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the DoxX family. {ECO 0000305}. # SUBCELLULAR LOCATION YPHA_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG COG2259 LUCA # eggNOG ENOG4108SB3 Bacteria BLAST swissprot:YPHA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YPHA_ECOLI BioCyc ECOL316407:JW2527-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2527-MONOMER BioCyc EcoCyc:G7337-MONOMER http://biocyc.org/getid?id=EcoCyc:G7337-MONOMER COG COG2259 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2259 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL Y11070 http://www.ebi.ac.uk/ena/data/view/Y11070 EchoBASE EB3235 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3235 EcoGene EG13462 http://www.ecogene.org/geneInfo.php?eg_id=EG13462 EnsemblBacteria AAC75596 http://www.ensemblgenomes.org/id/AAC75596 EnsemblBacteria AAC75596 http://www.ensemblgenomes.org/id/AAC75596 EnsemblBacteria BAA16446 http://www.ensemblgenomes.org/id/BAA16446 EnsemblBacteria BAA16446 http://www.ensemblgenomes.org/id/BAA16446 EnsemblBacteria BAA16446 http://www.ensemblgenomes.org/id/BAA16446 EnsemblBacteria b2543 http://www.ensemblgenomes.org/id/b2543 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 947365 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947365 HOGENOM HOG000198398 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000198398&db=HOGENOM6 InParanoid P0AD47 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AD47 InterPro IPR032808 http://www.ebi.ac.uk/interpro/entry/IPR032808 KEGG_Gene ecj:JW2527 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2527 KEGG_Gene eco:b2543 http://www.genome.jp/dbget-bin/www_bget?eco:b2543 KEGG_Orthology KO:K15977 http://www.genome.jp/dbget-bin/www_bget?KO:K15977 OMA NMVDPER http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NMVDPER PSORT swissprot:YPHA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YPHA_ECOLI PSORT-B swissprot:YPHA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YPHA_ECOLI PSORT2 swissprot:YPHA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YPHA_ECOLI Pfam PF07681 http://pfam.xfam.org/family/PF07681 Phobius swissprot:YPHA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YPHA_ECOLI PhylomeDB P0AD47 http://phylomedb.org/?seqid=P0AD47 ProteinModelPortal P0AD47 http://www.proteinmodelportal.org/query/uniprot/P0AD47 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417038 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417038 RefSeq WP_001094726 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001094726 STRING 511145.b2543 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2543&targetmode=cogs STRING COG2259 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2259&targetmode=cogs UniProtKB YPHA_ECOLI http://www.uniprot.org/uniprot/YPHA_ECOLI UniProtKB-AC P0AD47 http://www.uniprot.org/uniprot/P0AD47 charge swissprot:YPHA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YPHA_ECOLI eggNOG COG2259 http://eggnogapi.embl.de/nog_data/html/tree/COG2259 eggNOG ENOG4108SB3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108SB3 epestfind swissprot:YPHA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YPHA_ECOLI garnier swissprot:YPHA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YPHA_ECOLI helixturnhelix swissprot:YPHA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YPHA_ECOLI hmoment swissprot:YPHA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YPHA_ECOLI iep swissprot:YPHA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YPHA_ECOLI inforesidue swissprot:YPHA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YPHA_ECOLI octanol swissprot:YPHA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YPHA_ECOLI pepcoil swissprot:YPHA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YPHA_ECOLI pepdigest swissprot:YPHA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YPHA_ECOLI pepinfo swissprot:YPHA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YPHA_ECOLI pepnet swissprot:YPHA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YPHA_ECOLI pepstats swissprot:YPHA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YPHA_ECOLI pepwheel swissprot:YPHA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YPHA_ECOLI pepwindow swissprot:YPHA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YPHA_ECOLI sigcleave swissprot:YPHA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YPHA_ECOLI ## Database ID URL or Descriptions # AltName GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase {ECO:0000255|HAMAP-Rule MF_00956} # BIOPHYSICOCHEMICAL PROPERTIES FCL_ECOLI Kinetic parameters KM=9 uM for NADPH {ECO 0000269|PubMed 10480878, ECO 0000269|PubMed 11021971}; KM=109 uM for NADH {ECO 0000269|PubMed 10480878, ECO 0000269|PubMed 11021971}; KM=29 uM for GDP-4-keto-6-deoxymannose {ECO 0000269|PubMed 10480878, ECO 0000269|PubMed 11021971}; Vmax=363.5 umol/min/mg enzyme {ECO 0000269|PubMed 10480878, ECO 0000269|PubMed 11021971}; pH dependence Optimum pH is 6-6.5. {ECO 0000269|PubMed 10480878, ECO 0000269|PubMed 11021971}; # BRENDA 1.1.1.271 2026 # BioGrid 4259691 221 # CATALYTIC ACTIVITY FCL_ECOLI GDP-beta-L-fucose + NADP(+) = GDP-4-dehydro- alpha-D-rhamnose + NADPH. {ECO 0000255|HAMAP-Rule MF_00956, ECO 0000269|PubMed 10480878, ECO 0000269|PubMed 11021971, ECO 0000269|PubMed 9473059}. # CDD cd05239 GDP_FS_SDR_e # ENZYME REGULATION Subject to product inhibition by NADP and GDP- fucose. {ECO:0000269|PubMed 10480878}. # EcoGene EG11788 fcl # FUNCTION FCL_ECOLI Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. {ECO 0000255|HAMAP-Rule MF_00956, ECO 0000269|PubMed 10480878, ECO 0000269|PubMed 11021971, ECO 0000269|PubMed 9473059}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0016853 isomerase activity; IEA:UniProtKB-KW. # GO_function GO:0050577 GDP-L-fucose synthase activity; IDA:EcoCyc. # GO_function GO:0070401 NADP+ binding; IEA:UniProtKB-HAMAP. # GO_process GO:0009242 colanic acid biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0042351 'de novo' GDP-L-fucose biosynthetic process; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.50.720 -; 2. # HAMAP MF_00956 GDP_fucose_synth # IntAct P32055 2 # InterPro IPR001509 Epimerase_deHydtase # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR028614 GDP_fucose/colitose_synth # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00051 Fructose and mannose metabolism # KEGG_Pathway ko00520 Amino sugar and nucleotide sugar metabolism # Organism FCL_ECOLI Escherichia coli (strain K12) # PATHWAY Exopolysaccharide biosynthesis; colanic acid biosynthesis. {ECO:0000269|PubMed 9473059}. # PATHWAY FCL_ECOLI Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose step 2/2. {ECO 0000255|HAMAP-Rule MF_00956, ECO 0000269|PubMed 9473059}. # PATRIC 32119437 VBIEscCol129921_2129 # PDB 1BSV X-ray; 2.20 A; A=1-321 # PDB 1BWS X-ray; 2.20 A; A=1-321 # PDB 1E6U X-ray; 1.45 A; A=1-321 # PDB 1E7Q X-ray; 1.60 A; A=1-321 # PDB 1E7R X-ray; 1.60 A; A=1-321 # PDB 1E7S X-ray; 1.50 A; A=1-321 # PDB 1FXS X-ray; 2.30 A; A=1-321 # PDB 1GFS X-ray; 2.20 A; A=1-321 # PIR C64971 C64971 # Pfam PF01370 Epimerase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GDP-L-fucose synthase {ECO:0000255|HAMAP-Rule MF_00956} # RefSeq NP_416556 NC_000913.3 # RefSeq WP_000043654 NZ_LN832404.1 # SIMILARITY Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily. {ECO:0000255|HAMAP- Rule MF_00956}. # SUBCELLULAR LOCATION FCL_ECOLI Cytoplasm. # SUBUNIT FCL_ECOLI Homodimer. {ECO 0000269|PubMed 11021971, ECO 0000269|PubMed 9817848, ECO 0000269|PubMed 9862812}. # SUPFAM SSF51735 SSF51735 # UniPathway UPA00128 UER00191 # eggNOG COG0451 LUCA # eggNOG ENOG4105C30 Bacteria BLAST swissprot:FCL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FCL_ECOLI BioCyc ECOL316407:JW2037-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2037-MONOMER BioCyc EcoCyc:FCL-MONOMER http://biocyc.org/getid?id=EcoCyc:FCL-MONOMER BioCyc MetaCyc:FCL-MONOMER http://biocyc.org/getid?id=MetaCyc:FCL-MONOMER COG COG0451 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0451 DOI 10.1006/jmbi.2000.4106 http://dx.doi.org/10.1006/jmbi.2000.4106 DOI 10.1016/S0969-2126(98)00144-0 http://dx.doi.org/10.1016/S0969-2126(98)00144-0 DOI 10.1016/S0969-2126(98)00157-9 http://dx.doi.org/10.1016/S0969-2126(98)00157-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.274.38.26743 http://dx.doi.org/10.1074/jbc.274.38.26743 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.271 {ECO:0000255|HAMAP-Rule:MF_00956, ECO:0000269|PubMed:10480878, ECO:0000269|PubMed:11021971, ECO:0000269|PubMed:9473059} http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.271 {ECO:0000255|HAMAP-Rule:MF_00956, ECO:0000269|PubMed:10480878, ECO:0000269|PubMed:11021971, ECO:0000269|PubMed:9473059} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U38473 http://www.ebi.ac.uk/ena/data/view/U38473 ENZYME 1.1.1.271 {ECO:0000255|HAMAP-Rule:MF_00956, ECO:0000269|PubMed:10480878, ECO:0000269|PubMed:11021971, ECO:0000269|PubMed:9473059} http://enzyme.expasy.org/EC/1.1.1.271 {ECO:0000255|HAMAP-Rule:MF_00956, ECO:0000269|PubMed:10480878, ECO:0000269|PubMed:11021971, ECO:0000269|PubMed:9473059} EchoBASE EB1736 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1736 EcoGene EG11788 http://www.ecogene.org/geneInfo.php?eg_id=EG11788 EnsemblBacteria AAC75113 http://www.ensemblgenomes.org/id/AAC75113 EnsemblBacteria AAC75113 http://www.ensemblgenomes.org/id/AAC75113 EnsemblBacteria BAA15908 http://www.ensemblgenomes.org/id/BAA15908 EnsemblBacteria BAA15908 http://www.ensemblgenomes.org/id/BAA15908 EnsemblBacteria BAA15908 http://www.ensemblgenomes.org/id/BAA15908 EnsemblBacteria b2052 http://www.ensemblgenomes.org/id/b2052 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GO_function GO:0050577 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050577 GO_function GO:0070401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070401 GO_process GO:0009242 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009242 GO_process GO:0042351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042351 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 946563 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946563 HAMAP MF_00956 http://hamap.expasy.org/unirule/MF_00956 HOGENOM HOG000168011 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000168011&db=HOGENOM6 InParanoid P32055 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32055 IntAct P32055 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32055* IntEnz 1.1.1.271 {ECO:0000255|HAMAP-Rule:MF_00956, ECO:0000269|PubMed:10480878, ECO:0000269|PubMed:11021971, ECO:0000269|PubMed:9473059} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.271 {ECO:0000255|HAMAP-Rule:MF_00956, ECO:0000269|PubMed:10480878, ECO:0000269|PubMed:11021971, ECO:0000269|PubMed:9473059} InterPro IPR001509 http://www.ebi.ac.uk/interpro/entry/IPR001509 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR028614 http://www.ebi.ac.uk/interpro/entry/IPR028614 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2037 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2037 KEGG_Gene eco:b2052 http://www.genome.jp/dbget-bin/www_bget?eco:b2052 KEGG_Orthology KO:K02377 http://www.genome.jp/dbget-bin/www_bget?KO:K02377 KEGG_Pathway ko00051 http://www.genome.jp/kegg-bin/show_pathway?ko00051 KEGG_Pathway ko00520 http://www.genome.jp/kegg-bin/show_pathway?ko00520 KEGG_Reaction rn:R05692 http://www.genome.jp/dbget-bin/www_bget?rn:R05692 OMA RMHTAKL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RMHTAKL PDB 1BSV http://www.ebi.ac.uk/pdbe-srv/view/entry/1BSV PDB 1BWS http://www.ebi.ac.uk/pdbe-srv/view/entry/1BWS PDB 1E6U http://www.ebi.ac.uk/pdbe-srv/view/entry/1E6U PDB 1E7Q http://www.ebi.ac.uk/pdbe-srv/view/entry/1E7Q PDB 1E7R http://www.ebi.ac.uk/pdbe-srv/view/entry/1E7R PDB 1E7S http://www.ebi.ac.uk/pdbe-srv/view/entry/1E7S PDB 1FXS http://www.ebi.ac.uk/pdbe-srv/view/entry/1FXS PDB 1GFS http://www.ebi.ac.uk/pdbe-srv/view/entry/1GFS PDBsum 1BSV http://www.ebi.ac.uk/pdbsum/1BSV PDBsum 1BWS http://www.ebi.ac.uk/pdbsum/1BWS PDBsum 1E6U http://www.ebi.ac.uk/pdbsum/1E6U PDBsum 1E7Q http://www.ebi.ac.uk/pdbsum/1E7Q PDBsum 1E7R http://www.ebi.ac.uk/pdbsum/1E7R PDBsum 1E7S http://www.ebi.ac.uk/pdbsum/1E7S PDBsum 1FXS http://www.ebi.ac.uk/pdbsum/1FXS PDBsum 1GFS http://www.ebi.ac.uk/pdbsum/1GFS PSORT swissprot:FCL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FCL_ECOLI PSORT-B swissprot:FCL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FCL_ECOLI PSORT2 swissprot:FCL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FCL_ECOLI Pfam PF01370 http://pfam.xfam.org/family/PF01370 Phobius swissprot:FCL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FCL_ECOLI PhylomeDB P32055 http://phylomedb.org/?seqid=P32055 ProteinModelPortal P32055 http://www.proteinmodelportal.org/query/uniprot/P32055 PubMed 10480878 http://www.ncbi.nlm.nih.gov/pubmed/10480878 PubMed 11021971 http://www.ncbi.nlm.nih.gov/pubmed/11021971 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7815923 http://www.ncbi.nlm.nih.gov/pubmed/7815923 PubMed 8759852 http://www.ncbi.nlm.nih.gov/pubmed/8759852 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9473059 http://www.ncbi.nlm.nih.gov/pubmed/9473059 PubMed 9817848 http://www.ncbi.nlm.nih.gov/pubmed/9817848 PubMed 9862812 http://www.ncbi.nlm.nih.gov/pubmed/9862812 RefSeq NP_416556 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416556 RefSeq WP_000043654 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000043654 SMR P32055 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32055 STRING 511145.b2052 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2052&targetmode=cogs STRING COG0451 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0451&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB FCL_ECOLI http://www.uniprot.org/uniprot/FCL_ECOLI UniProtKB-AC P32055 http://www.uniprot.org/uniprot/P32055 charge swissprot:FCL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FCL_ECOLI eggNOG COG0451 http://eggnogapi.embl.de/nog_data/html/tree/COG0451 eggNOG ENOG4105C30 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C30 epestfind swissprot:FCL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FCL_ECOLI garnier swissprot:FCL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FCL_ECOLI helixturnhelix swissprot:FCL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FCL_ECOLI hmoment swissprot:FCL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FCL_ECOLI iep swissprot:FCL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FCL_ECOLI inforesidue swissprot:FCL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FCL_ECOLI octanol swissprot:FCL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FCL_ECOLI pepcoil swissprot:FCL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FCL_ECOLI pepdigest swissprot:FCL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FCL_ECOLI pepinfo swissprot:FCL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FCL_ECOLI pepnet swissprot:FCL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FCL_ECOLI pepstats swissprot:FCL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FCL_ECOLI pepwheel swissprot:FCL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FCL_ECOLI pepwindow swissprot:FCL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FCL_ECOLI sigcleave swissprot:FCL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FCL_ECOLI ## Database ID URL or Descriptions # AltName SOPB_ECOLI Plasmid partition protein B # FUNCTION SOPB_ECOLI Control of plasmid partitioning; required to recognize the cis-acting. Binds specifically with the DNA segment containing the sopC region. SopB is trans-acting. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0030541 plasmid partitioning; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # InterPro IPR003115 ParB/Sulfiredoxin_dom # InterPro IPR004437 ParB/RepB/Spo0J # MISCELLANEOUS SOPB_ECOLI Overproduction of SopB protein causes IncG incompatibility. # Organism SOPB_ECOLI Escherichia coli (strain K12) # PDB 3KZ5 X-ray; 1.58 A; A/B/E=276-323 # PDB 3MKW X-ray; 2.99 A; B/P=155-272 # PDB 3MKY X-ray; 2.86 A; B/P=155-323 # PDB 3MKZ X-ray; 2.98 A; A/B/N/U=155-272 # PIR T00244 T00244 # Pfam PF02195 ParBc # RecName SOPB_ECOLI Protein SopB # RefSeq NP_061426 NC_002483.1 # RefSeq WP_000817031 NZ_CP014273.1 # RefSeq YP_001294715 NC_009602.1 # SIMILARITY Belongs to the ParB family. {ECO 0000305}. # SMART SM00470 ParB # SUPFAM SSF110849 SSF110849 # TIGRFAMs TIGR00180 parB_part BLAST swissprot:SOPB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SOPB_ECOLI DOI 10.1016/0022-2836(86)90459-6 http://dx.doi.org/10.1016/0022-2836(86)90459-6 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL M12987 http://www.ebi.ac.uk/ena/data/view/M12987 EMBL X04619 http://www.ebi.ac.uk/ena/data/view/X04619 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0030541 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030541 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 1263559 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263559 GeneID 5290921 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5290921 InterPro IPR003115 http://www.ebi.ac.uk/interpro/entry/IPR003115 InterPro IPR004437 http://www.ebi.ac.uk/interpro/entry/IPR004437 OMA RCINTAR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RCINTAR PDB 3KZ5 http://www.ebi.ac.uk/pdbe-srv/view/entry/3KZ5 PDB 3MKW http://www.ebi.ac.uk/pdbe-srv/view/entry/3MKW PDB 3MKY http://www.ebi.ac.uk/pdbe-srv/view/entry/3MKY PDB 3MKZ http://www.ebi.ac.uk/pdbe-srv/view/entry/3MKZ PDBsum 3KZ5 http://www.ebi.ac.uk/pdbsum/3KZ5 PDBsum 3MKW http://www.ebi.ac.uk/pdbsum/3MKW PDBsum 3MKY http://www.ebi.ac.uk/pdbsum/3MKY PDBsum 3MKZ http://www.ebi.ac.uk/pdbsum/3MKZ PSORT swissprot:SOPB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SOPB_ECOLI PSORT-B swissprot:SOPB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SOPB_ECOLI PSORT2 swissprot:SOPB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SOPB_ECOLI Pfam PF02195 http://pfam.xfam.org/family/PF02195 Phobius swissprot:SOPB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SOPB_ECOLI ProteinModelPortal P62558 http://www.proteinmodelportal.org/query/uniprot/P62558 PubMed 3029390 http://www.ncbi.nlm.nih.gov/pubmed/3029390 RefSeq NP_061426 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061426 RefSeq WP_000817031 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000817031 RefSeq YP_001294715 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001294715 SMART SM00470 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00470 SMR P62558 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P62558 SUPFAM SSF110849 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF110849 TIGRFAMs TIGR00180 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00180 UniProtKB SOPB_ECOLI http://www.uniprot.org/uniprot/SOPB_ECOLI UniProtKB-AC P62558 http://www.uniprot.org/uniprot/P62558 charge swissprot:SOPB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SOPB_ECOLI epestfind swissprot:SOPB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SOPB_ECOLI garnier swissprot:SOPB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SOPB_ECOLI helixturnhelix swissprot:SOPB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SOPB_ECOLI hmoment swissprot:SOPB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SOPB_ECOLI iep swissprot:SOPB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SOPB_ECOLI inforesidue swissprot:SOPB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SOPB_ECOLI octanol swissprot:SOPB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SOPB_ECOLI pepcoil swissprot:SOPB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SOPB_ECOLI pepdigest swissprot:SOPB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SOPB_ECOLI pepinfo swissprot:SOPB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SOPB_ECOLI pepnet swissprot:SOPB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SOPB_ECOLI pepstats swissprot:SOPB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SOPB_ECOLI pepwheel swissprot:SOPB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SOPB_ECOLI pepwindow swissprot:SOPB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SOPB_ECOLI sigcleave swissprot:SOPB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SOPB_ECOLI ## Database ID URL or Descriptions # BioGrid 4261366 14 # EcoGene EG13224 yaeR # Gene3D 3.10.180.10 -; 1. # IntAct P52096 2 # InterPro IPR004360 Glyas_Fos-R_dOase_dom # InterPro IPR029068 Glyas_Bleomycin-R_OHBP_Dase # Organism YAER_ECOLI Escherichia coli (strain K12) # PATRIC 32115485 VBIEscCol129921_0194 # PIR C64743 C64743 # Pfam PF00903 Glyoxalase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAER_ECOLI Uncharacterized protein YaeR # RefSeq NP_414729 NC_000913.3 # RefSeq WP_000901099 NZ_LN832404.1 # SIMILARITY To B.subtilis YwkD. {ECO 0000305}. # SUPFAM SSF54593 SSF54593 # eggNOG COG0346 LUCA # eggNOG ENOG4108YZK Bacteria BLAST swissprot:YAER_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAER_ECOLI BioCyc ECOL316407:JW0182-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0182-MONOMER BioCyc EcoCyc:G6095-MONOMER http://biocyc.org/getid?id=EcoCyc:G6095-MONOMER COG COG0346 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0346 DIP DIP-11206N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11206N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1998.00981.x http://dx.doi.org/10.1046/j.1365-2958.1998.00981.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D49445 http://www.ebi.ac.uk/ena/data/view/D49445 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EMBL Z50870 http://www.ebi.ac.uk/ena/data/view/Z50870 EchoBASE EB3015 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3015 EcoGene EG13224 http://www.ecogene.org/geneInfo.php?eg_id=EG13224 EnsemblBacteria AAC73298 http://www.ensemblgenomes.org/id/AAC73298 EnsemblBacteria AAC73298 http://www.ensemblgenomes.org/id/AAC73298 EnsemblBacteria BAA77862 http://www.ensemblgenomes.org/id/BAA77862 EnsemblBacteria BAA77862 http://www.ensemblgenomes.org/id/BAA77862 EnsemblBacteria BAA77862 http://www.ensemblgenomes.org/id/BAA77862 EnsemblBacteria b0187 http://www.ensemblgenomes.org/id/b0187 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.10.180.10 http://www.cathdb.info/version/latest/superfamily/3.10.180.10 GeneID 944875 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944875 HOGENOM HOG000232011 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000232011&db=HOGENOM6 InParanoid P52096 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P52096 IntAct P52096 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P52096* InterPro IPR004360 http://www.ebi.ac.uk/interpro/entry/IPR004360 InterPro IPR029068 http://www.ebi.ac.uk/interpro/entry/IPR029068 KEGG_Gene ecj:JW0182 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0182 KEGG_Gene eco:b0187 http://www.genome.jp/dbget-bin/www_bget?eco:b0187 KEGG_Orthology KO:K08234 http://www.genome.jp/dbget-bin/www_bget?KO:K08234 OMA RNSYKLD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RNSYKLD PSORT swissprot:YAER_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAER_ECOLI PSORT-B swissprot:YAER_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAER_ECOLI PSORT2 swissprot:YAER_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAER_ECOLI Pfam PF00903 http://pfam.xfam.org/family/PF00903 Phobius swissprot:YAER_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAER_ECOLI ProteinModelPortal P52096 http://www.proteinmodelportal.org/query/uniprot/P52096 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9723924 http://www.ncbi.nlm.nih.gov/pubmed/9723924 RefSeq NP_414729 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414729 RefSeq WP_000901099 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000901099 SMR P52096 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P52096 STRING 511145.b0187 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0187&targetmode=cogs STRING COG0346 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0346&targetmode=cogs SUPFAM SSF54593 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54593 UniProtKB YAER_ECOLI http://www.uniprot.org/uniprot/YAER_ECOLI UniProtKB-AC P52096 http://www.uniprot.org/uniprot/P52096 charge swissprot:YAER_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAER_ECOLI eggNOG COG0346 http://eggnogapi.embl.de/nog_data/html/tree/COG0346 eggNOG ENOG4108YZK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108YZK epestfind swissprot:YAER_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAER_ECOLI garnier swissprot:YAER_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAER_ECOLI helixturnhelix swissprot:YAER_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAER_ECOLI hmoment swissprot:YAER_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAER_ECOLI iep swissprot:YAER_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAER_ECOLI inforesidue swissprot:YAER_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAER_ECOLI octanol swissprot:YAER_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAER_ECOLI pepcoil swissprot:YAER_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAER_ECOLI pepdigest swissprot:YAER_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAER_ECOLI pepinfo swissprot:YAER_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAER_ECOLI pepnet swissprot:YAER_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAER_ECOLI pepstats swissprot:YAER_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAER_ECOLI pepwheel swissprot:YAER_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAER_ECOLI pepwindow swissprot:YAER_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAER_ECOLI sigcleave swissprot:YAER_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAER_ECOLI ## Database ID URL or Descriptions # AltName PRC_ECOLI C-terminal-processing peptidase # AltName PRC_ECOLI PRC protein # AltName PRC_ECOLI Protease Re # BRENDA 3.4.21.102 2026 # BioGrid 4263463 432 # CATALYTIC ACTIVITY PRC_ECOLI The enzyme shows specific recognition of a C- terminal tripeptide, Xaa-Yaa-Zaa, in which Xaa is preferably Ala or Leu, Yaa is preferably Ala or Tyr, and Zaa is preferably Ala, but then cleaves at a variable distance from the C-terminus. A typical cleavage is -Ala-Ala-|-Arg-Ala-Ala-Lys-Glu-Asn-Tyr-Ala- Leu-Ala-Ala. # EcoGene EG10760 prc # FUNCTION PRC_ECOLI Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3 (PBP3). May be involved in protection of the bacterium from thermal and osmotic stresses. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0004175 endopeptidase activity; IDA:EcoliWiki. # GO_function GO:0008236 serine-type peptidase activity; IEA:UniProtKB-KW. # GO_process GO:0006508 proteolysis; IDA:EcoliWiki. # GO_process GO:0030163 protein catabolic process; IDA:EcoliWiki. # GO_process GO:0046677 response to antibiotic; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0008233 peptidase activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # Gene3D 2.30.42.10 -; 1. # Gene3D 3.90.226.10 -; 2. # IntAct P23865 3 # InterPro IPR001478 PDZ # InterPro IPR004447 Peptidase_S41A # InterPro IPR005151 Tail-specific_protease # InterPro IPR020992 Tail_Prtase_C # InterPro IPR029045 ClpP/crotonase-like_dom # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # Organism PRC_ECOLI Escherichia coli (strain K12) # PATRIC 32118981 VBIEscCol129921_1908 # PIR A41798 A41798 # PROSITE PS50106 PDZ # Pfam PF00595 PDZ # Pfam PF03572 Peptidase_S41 # Pfam PF11818 DUF3340 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PRC_ECOLI Tail-specific protease # RefSeq NP_416344 NC_000913.3 # RefSeq WP_001055791 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA00578.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the peptidase S41A family. {ECO 0000305}. # SIMILARITY Contains 1 PDZ (DHR) domain. {ECO:0000255|PROSITE- ProRule PRU00143}. # SMART SM00228 PDZ # SMART SM00245 TSPc # SUBCELLULAR LOCATION PRC_ECOLI Cell inner membrane; Peripheral membrane protein; Periplasmic side. # SUPFAM SSF50156 SSF50156 # SUPFAM SSF52096 SSF52096; 2 # TCDB 9.B.174.1 the two tunnel gated c-terminal processing protease (ctp) family # TIGRFAMs TIGR00225 prc # eggNOG COG0793 LUCA # eggNOG ENOG4105CN1 Bacteria BLAST swissprot:PRC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PRC_ECOLI BioCyc ECOL316407:JW1819-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1819-MONOMER BioCyc EcoCyc:EG10760-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10760-MONOMER BioCyc MetaCyc:EG10760-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10760-MONOMER COG COG0793 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0793 DIP DIP-10557N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10557N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.89.1.295 http://dx.doi.org/10.1073/pnas.89.1.295 DOI 10.1074/jbc.270.48.28864 http://dx.doi.org/10.1074/jbc.270.48.28864 DOI 10.1074/jbc.271.5.2589 http://dx.doi.org/10.1074/jbc.271.5.2589 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.21.102 http://www.genome.jp/dbget-bin/www_bget?EC:3.4.21.102 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D00674 http://www.ebi.ac.uk/ena/data/view/D00674 EMBL D00674 http://www.ebi.ac.uk/ena/data/view/D00674 EMBL L48409 http://www.ebi.ac.uk/ena/data/view/L48409 EMBL M75634 http://www.ebi.ac.uk/ena/data/view/M75634 EMBL S49803 http://www.ebi.ac.uk/ena/data/view/S49803 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.4.21.102 http://enzyme.expasy.org/EC/3.4.21.102 EchoBASE EB0753 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0753 EcoGene EG10760 http://www.ecogene.org/geneInfo.php?eg_id=EG10760 EnsemblBacteria AAC74900 http://www.ensemblgenomes.org/id/AAC74900 EnsemblBacteria AAC74900 http://www.ensemblgenomes.org/id/AAC74900 EnsemblBacteria BAA15638 http://www.ensemblgenomes.org/id/BAA15638 EnsemblBacteria BAA15638 http://www.ensemblgenomes.org/id/BAA15638 EnsemblBacteria BAA15638 http://www.ensemblgenomes.org/id/BAA15638 EnsemblBacteria b1830 http://www.ensemblgenomes.org/id/b1830 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0004175 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004175 GO_function GO:0008236 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008236 GO_process GO:0006508 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006508 GO_process GO:0030163 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030163 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 2.30.42.10 http://www.cathdb.info/version/latest/superfamily/2.30.42.10 Gene3D 3.90.226.10 http://www.cathdb.info/version/latest/superfamily/3.90.226.10 GeneID 946096 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946096 HOGENOM HOG000277886 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000277886&db=HOGENOM6 InParanoid P23865 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23865 IntAct P23865 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P23865* IntEnz 3.4.21.102 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.21.102 InterPro IPR001478 http://www.ebi.ac.uk/interpro/entry/IPR001478 InterPro IPR004447 http://www.ebi.ac.uk/interpro/entry/IPR004447 InterPro IPR005151 http://www.ebi.ac.uk/interpro/entry/IPR005151 InterPro IPR020992 http://www.ebi.ac.uk/interpro/entry/IPR020992 InterPro IPR029045 http://www.ebi.ac.uk/interpro/entry/IPR029045 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW1819 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1819 KEGG_Gene eco:b1830 http://www.genome.jp/dbget-bin/www_bget?eco:b1830 KEGG_Orthology KO:K03797 http://www.genome.jp/dbget-bin/www_bget?KO:K03797 MINT MINT-1283244 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1283244 OMA IEIPAFY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IEIPAFY PROSITE PS50106 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50106 PSORT swissprot:PRC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PRC_ECOLI PSORT-B swissprot:PRC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PRC_ECOLI PSORT2 swissprot:PRC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PRC_ECOLI Pfam PF00595 http://pfam.xfam.org/family/PF00595 Pfam PF03572 http://pfam.xfam.org/family/PF03572 Pfam PF11818 http://pfam.xfam.org/family/PF11818 Phobius swissprot:PRC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PRC_ECOLI PhylomeDB P23865 http://phylomedb.org/?seqid=P23865 ProteinModelPortal P23865 http://www.proteinmodelportal.org/query/uniprot/P23865 PubMed 10049386 http://www.ncbi.nlm.nih.gov/pubmed/10049386 PubMed 1447154 http://www.ncbi.nlm.nih.gov/pubmed/1447154 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1729701 http://www.ncbi.nlm.nih.gov/pubmed/1729701 PubMed 1856173 http://www.ncbi.nlm.nih.gov/pubmed/1856173 PubMed 7499412 http://www.ncbi.nlm.nih.gov/pubmed/7499412 PubMed 8576225 http://www.ncbi.nlm.nih.gov/pubmed/8576225 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416344 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416344 RefSeq WP_001055791 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001055791 SMART SM00228 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00228 SMART SM00245 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00245 SMR P23865 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P23865 STRING 511145.b1830 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1830&targetmode=cogs STRING COG0793 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0793&targetmode=cogs SUPFAM SSF50156 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50156 SUPFAM SSF52096 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52096 TCDB 9.B.174.1 http://www.tcdb.org/search/result.php?tc=9.B.174.1 TIGRFAMs TIGR00225 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00225 UniProtKB PRC_ECOLI http://www.uniprot.org/uniprot/PRC_ECOLI UniProtKB-AC P23865 http://www.uniprot.org/uniprot/P23865 charge swissprot:PRC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PRC_ECOLI eggNOG COG0793 http://eggnogapi.embl.de/nog_data/html/tree/COG0793 eggNOG ENOG4105CN1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CN1 epestfind swissprot:PRC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PRC_ECOLI garnier swissprot:PRC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PRC_ECOLI helixturnhelix swissprot:PRC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PRC_ECOLI hmoment swissprot:PRC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PRC_ECOLI iep swissprot:PRC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PRC_ECOLI inforesidue swissprot:PRC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PRC_ECOLI octanol swissprot:PRC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PRC_ECOLI pepcoil swissprot:PRC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PRC_ECOLI pepdigest swissprot:PRC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PRC_ECOLI pepinfo swissprot:PRC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PRC_ECOLI pepnet swissprot:PRC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PRC_ECOLI pepstats swissprot:PRC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PRC_ECOLI pepwheel swissprot:PRC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PRC_ECOLI pepwindow swissprot:PRC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PRC_ECOLI sigcleave swissprot:PRC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PRC_ECOLI ## Database ID URL or Descriptions # AltName REQ1_ECOLI Antitermination protein Q homolog from lambdoid prophage DLP12 # BioGrid 4260894 131 # EcoGene EG13633 quuD # FUNCTION REQ1_ECOLI Positively regulate expression of some phage genes. Bacterial host RNA polymerase modified by antitermination proteins transcribes through termination sites that otherwise prevent expression of the regulated genes (By similarity). {ECO 0000250}. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0031564 transcription antitermination; IEA:UniProtKB-KW. # GO_process GO:0044010 single-species biofilm formation; IMP:EcoCyc. # GO_process GO:0060567 negative regulation of DNA-templated transcription, termination; IEA:InterPro. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # IntAct Q47274 4 # InterPro IPR010534 Phage_933W_GpQ # MISCELLANEOUS REQ1_ECOLI Encoded by the cryptic lambdoid prophage DLP12. # Organism REQ1_ECOLI Escherichia coli (strain K12) # PATRIC 32116266 VBIEscCol129921_0573 # PIR S66593 S66593 # Pfam PF06530 Phage_antitermQ # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Prophage antitermination protein Q homolog QuuD {ECO 0000305} # RefSeq NP_415083 NC_000913.3 # RefSeq WP_001204791 NZ_LN832404.1 # SIMILARITY Belongs to the phage antitermination Q type 1 family. {ECO 0000305}. # eggNOG ENOG4105HRS Bacteria # eggNOG ENOG4111PZ9 LUCA BLAST swissprot:REQ1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:REQ1_ECOLI BioCyc ECOL316407:JW0539-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0539-MONOMER BioCyc EcoCyc:G6307-MONOMER http://biocyc.org/getid?id=EcoCyc:G6307-MONOMER DOI 10.1006/jmbi.1996.0185 http://dx.doi.org/10.1006/jmbi.1996.0185 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EMBL X92587 http://www.ebi.ac.uk/ena/data/view/X92587 EchoBASE EB3397 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3397 EcoGene EG13633 http://www.ecogene.org/geneInfo.php?eg_id=EG13633 EnsemblBacteria AAC73652 http://www.ensemblgenomes.org/id/AAC73652 EnsemblBacteria AAC73652 http://www.ensemblgenomes.org/id/AAC73652 EnsemblBacteria BAE76327 http://www.ensemblgenomes.org/id/BAE76327 EnsemblBacteria BAE76327 http://www.ensemblgenomes.org/id/BAE76327 EnsemblBacteria BAE76327 http://www.ensemblgenomes.org/id/BAE76327 EnsemblBacteria b0551 http://www.ensemblgenomes.org/id/b0551 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0031564 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031564 GO_process GO:0044010 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044010 GO_process GO:0060567 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060567 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 945177 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945177 HOGENOM HOG000119341 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000119341&db=HOGENOM6 IntAct Q47274 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q47274* InterPro IPR010534 http://www.ebi.ac.uk/interpro/entry/IPR010534 KEGG_Gene ecj:JW0539 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0539 KEGG_Gene eco:b0551 http://www.genome.jp/dbget-bin/www_bget?eco:b0551 OMA QKEPINI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QKEPINI PSORT swissprot:REQ1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:REQ1_ECOLI PSORT-B swissprot:REQ1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:REQ1_ECOLI PSORT2 swissprot:REQ1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:REQ1_ECOLI Pfam PF06530 http://pfam.xfam.org/family/PF06530 Phobius swissprot:REQ1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:REQ1_ECOLI ProteinModelPortal Q47274 http://www.proteinmodelportal.org/query/uniprot/Q47274 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8648624 http://www.ncbi.nlm.nih.gov/pubmed/8648624 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415083 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415083 RefSeq WP_001204791 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001204791 STRING 511145.b0551 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0551&targetmode=cogs UniProtKB REQ1_ECOLI http://www.uniprot.org/uniprot/REQ1_ECOLI UniProtKB-AC Q47274 http://www.uniprot.org/uniprot/Q47274 charge swissprot:REQ1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:REQ1_ECOLI eggNOG ENOG4105HRS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105HRS eggNOG ENOG4111PZ9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111PZ9 epestfind swissprot:REQ1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:REQ1_ECOLI garnier swissprot:REQ1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:REQ1_ECOLI helixturnhelix swissprot:REQ1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:REQ1_ECOLI hmoment swissprot:REQ1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:REQ1_ECOLI iep swissprot:REQ1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:REQ1_ECOLI inforesidue swissprot:REQ1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:REQ1_ECOLI octanol swissprot:REQ1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:REQ1_ECOLI pepcoil swissprot:REQ1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:REQ1_ECOLI pepdigest swissprot:REQ1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:REQ1_ECOLI pepinfo swissprot:REQ1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:REQ1_ECOLI pepnet swissprot:REQ1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:REQ1_ECOLI pepstats swissprot:REQ1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:REQ1_ECOLI pepwheel swissprot:REQ1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:REQ1_ECOLI pepwindow swissprot:REQ1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:REQ1_ECOLI sigcleave swissprot:REQ1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:REQ1_ECOLI ## Database ID URL or Descriptions # DISRUPTION PHENOTYPE No F pili expressed on cell surface. {ECO:0000269|PubMed 1355084}. # FUNCTION TRAW_ECOLI Involved in F-pilus assembly. Required for F plasmid conjugative transfer. {ECO 0000305|PubMed 1355084}. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_process GO:0000746 conjugation; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0008150 biological_process # InterPro IPR014114 TraW # InterPro IPR025864 TraW_N_dom # Organism TRAW_ECOLI Escherichia coli (strain K12) # PIR B42938 B42938 # Pfam PF12477 TraW_N # RecName TRAW_ECOLI Protein TraW # RefSeq NP_061465 NC_002483.1 # RefSeq NP_862931 NC_004998.1 # RefSeq WP_001203720 NZ_CP014273.1 # RefSeq YP_001294745 NC_009602.1 # RefSeq YP_001711952 NC_010409.1 # RefSeq YP_003937630 NC_014615.1 # RefSeq YP_004870066 NC_016039.1 # RefSeq YP_008997945 NC_023315.1 # RefSeq YP_009070603 NC_025175.1 # SUBCELLULAR LOCATION TRAW_ECOLI Periplasm {ECO 0000269|PubMed 1355084}. # TIGRFAMs TIGR02743 TraW BLAST swissprot:TRAW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRAW_ECOLI DIP DIP-28103N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-28103N EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL M34695 http://www.ebi.ac.uk/ena/data/view/M34695 EMBL M93106 http://www.ebi.ac.uk/ena/data/view/M93106 EMBL U01159 http://www.ebi.ac.uk/ena/data/view/U01159 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_process GO:0000746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000746 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 11185572 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11185572 GeneID 1263571 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263571 GeneID 1446495 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1446495 GeneID 18194772 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18194772 GeneID 20492671 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20492671 GeneID 5290979 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5290979 GeneID 5962173 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5962173 GeneID 9846174 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9846174 InterPro IPR014114 http://www.ebi.ac.uk/interpro/entry/IPR014114 InterPro IPR025864 http://www.ebi.ac.uk/interpro/entry/IPR025864 OMA HERLVFF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HERLVFF PSORT swissprot:TRAW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRAW_ECOLI PSORT-B swissprot:TRAW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRAW_ECOLI PSORT2 swissprot:TRAW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRAW_ECOLI Pfam PF12477 http://pfam.xfam.org/family/PF12477 Phobius swissprot:TRAW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRAW_ECOLI ProteinModelPortal P18472 http://www.proteinmodelportal.org/query/uniprot/P18472 PubMed 1355084 http://www.ncbi.nlm.nih.gov/pubmed/1355084 PubMed 2198250 http://www.ncbi.nlm.nih.gov/pubmed/2198250 PubMed 7915817 http://www.ncbi.nlm.nih.gov/pubmed/7915817 RefSeq NP_061465 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061465 RefSeq NP_862931 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_862931 RefSeq WP_001203720 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001203720 RefSeq YP_001294745 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001294745 RefSeq YP_001711952 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001711952 RefSeq YP_003937630 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_003937630 RefSeq YP_004870066 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_004870066 RefSeq YP_008997945 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_008997945 RefSeq YP_009070603 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009070603 TIGRFAMs TIGR02743 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02743 UniProtKB TRAW_ECOLI http://www.uniprot.org/uniprot/TRAW_ECOLI UniProtKB-AC P18472 http://www.uniprot.org/uniprot/P18472 charge swissprot:TRAW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRAW_ECOLI epestfind swissprot:TRAW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRAW_ECOLI garnier swissprot:TRAW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRAW_ECOLI helixturnhelix swissprot:TRAW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRAW_ECOLI hmoment swissprot:TRAW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRAW_ECOLI iep swissprot:TRAW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRAW_ECOLI inforesidue swissprot:TRAW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRAW_ECOLI octanol swissprot:TRAW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRAW_ECOLI pepcoil swissprot:TRAW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRAW_ECOLI pepdigest swissprot:TRAW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRAW_ECOLI pepinfo swissprot:TRAW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRAW_ECOLI pepnet swissprot:TRAW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRAW_ECOLI pepstats swissprot:TRAW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRAW_ECOLI pepwheel swissprot:TRAW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRAW_ECOLI pepwindow swissprot:TRAW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRAW_ECOLI sigcleave swissprot:TRAW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRAW_ECOLI ## Database ID URL or Descriptions # AltName PFKA_ECOLI 6-phosphofructokinase isozyme I # AltName Phosphohexokinase 1 {ECO:0000255|HAMAP-Rule MF_00339} # BRENDA 2.7.1.11 2026 # BioGrid 4261224 4 # CATALYTIC ACTIVITY ATP + D-fructose 6-phosphate = ADP + D- fructose 1,6-bisphosphate. {ECO:0000255|HAMAP-Rule MF_00339}. # CDD cd00763 Bacterial_PFK # COFACTOR PFKA_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_00339, ECO 0000269|PubMed 2975709}; # ENZYME REGULATION Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate. {ECO:0000255|HAMAP-Rule MF_00339}. # EcoGene EG10699 pfkA # FUNCTION PFKA_ECOLI Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. {ECO 0000255|HAMAP-Rule MF_00339}. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005945 6-phosphofructokinase complex; IDA:EcoliWiki. # GO_function GO:0000287 magnesium ion binding; IDA:EcoliWiki. # GO_function GO:0003872 6-phosphofructokinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IMP:EcoliWiki. # GO_function GO:0019003 GDP binding; IDA:EcoCyc. # GO_function GO:0032553 ribonucleotide binding; IDA:EcoliWiki. # GO_function GO:0042802 identical protein binding; IDA:EcoliWiki. # GO_process GO:0006002 fructose 6-phosphate metabolic process; IEA:InterPro. # GO_process GO:0006007 glucose catabolic process; IMP:EcoliWiki. # GO_process GO:0006096 glycolytic process; IDA:EcoliWiki. # GO_process GO:0044275 cellular carbohydrate catabolic process; IMP:EcoliWiki. # GO_process GO:0051289 protein homotetramerization; IPI:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # HAMAP MF_00339 Phosphofructokinase_I_B1 # IntAct P0A796 7 # InterPro IPR000023 Phosphofructokinase_dom # InterPro IPR012003 ATP_PFK_prok-type # InterPro IPR012828 PFKA_ATP_prok # InterPro IPR015912 Phosphofructokinase_CS # InterPro IPR022953 ATP_PFK # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00010 Glycolysis / Gluconeogenesis # KEGG_Pathway ko00030 Pentose phosphate pathway # KEGG_Pathway ko00051 Fructose and mannose metabolism # KEGG_Pathway ko00052 Galactose metabolism # KEGG_Pathway ko00680 Methane metabolism # Organism PFKA_ECOLI Escherichia coli (strain K12) # PATHWAY Carbohydrate degradation; glycolysis; D-glyceraldehyde 3- phosphate and glycerone phosphate from D-glucose: step 3/4. {ECO 0000255|HAMAP-Rule:MF_00339}. # PATRIC 32123343 VBIEscCol129921_4032 # PDB 1PFK X-ray; 2.40 A; A/B=1-320 # PDB 2PFK X-ray; 2.40 A; A/B/C/D=1-320 # PIR G65197 KIECFA # PIRSF PIRSF000532 ATP_PFK_prok # PRINTS PR00476 PHFRCTKINASE # PROSITE PS00433 PHOSPHOFRUCTOKINASE # Pfam PF00365 PFK # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ATP-dependent 6-phosphofructokinase isozyme 1 {ECO:0000255|HAMAP-Rule MF_00339} # RefSeq NP_418351 NC_000913.3 # RefSeq WP_000591795 NZ_LN832404.1 # SIMILARITY Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade "B1" sub-subfamily. {ECO:0000255|HAMAP-Rule MF_00339}. # SUBCELLULAR LOCATION PFKA_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00339, ECO 0000305|PubMed 17895580}. # SUBUNIT PFKA_ECOLI Homotetramer. {ECO 0000255|HAMAP-Rule MF_00339, ECO 0000269|PubMed 2975709}. # SUPFAM SSF53784 SSF53784 # TIGRFAMs TIGR02482 PFKA_ATP # UniPathway UPA00109 UER00182 # eggNOG COG0205 LUCA # eggNOG ENOG4105CTQ Bacteria BLAST swissprot:PFKA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PFKA_ECOLI BioCyc ECOL316407:JW3887-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3887-MONOMER BioCyc EcoCyc:6PFK-1-MONOMER http://biocyc.org/getid?id=EcoCyc:6PFK-1-MONOMER BioCyc MetaCyc:6PFK-1-MONOMER http://biocyc.org/getid?id=MetaCyc:6PFK-1-MONOMER COG COG0205 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0205 DIP DIP-35841N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35841N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0022-2836(88)90056-3 http://dx.doi.org/10.1016/0022-2836(88)90056-3 DOI 10.1016/0022-2836(89)90246-5 http://dx.doi.org/10.1016/0022-2836(89)90246-5 DOI 10.1038/327437a0 http://dx.doi.org/10.1038/327437a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1111/j.1432-1033.1985.tb08934.x http://dx.doi.org/10.1111/j.1432-1033.1985.tb08934.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1266/ggs.82.291 http://dx.doi.org/10.1266/ggs.82.291 EC_number EC:2.7.1.11 {ECO:0000255|HAMAP-Rule:MF_00339} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.11 {ECO:0000255|HAMAP-Rule:MF_00339} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X02519 http://www.ebi.ac.uk/ena/data/view/X02519 ENZYME 2.7.1.11 {ECO:0000255|HAMAP-Rule:MF_00339} http://enzyme.expasy.org/EC/2.7.1.11 {ECO:0000255|HAMAP-Rule:MF_00339} EchoBASE EB0693 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0693 EcoGene EG10699 http://www.ecogene.org/geneInfo.php?eg_id=EG10699 EnsemblBacteria AAC76898 http://www.ensemblgenomes.org/id/AAC76898 EnsemblBacteria AAC76898 http://www.ensemblgenomes.org/id/AAC76898 EnsemblBacteria BAE77394 http://www.ensemblgenomes.org/id/BAE77394 EnsemblBacteria BAE77394 http://www.ensemblgenomes.org/id/BAE77394 EnsemblBacteria BAE77394 http://www.ensemblgenomes.org/id/BAE77394 EnsemblBacteria b3916 http://www.ensemblgenomes.org/id/b3916 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005945 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005945 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0003872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003872 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0019003 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019003 GO_function GO:0032553 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032553 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0006002 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006002 GO_process GO:0006007 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006007 GO_process GO:0006096 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006096 GO_process GO:0044275 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044275 GO_process GO:0051289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051289 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GeneID 948412 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948412 HAMAP MF_00339 http://hamap.expasy.org/unirule/MF_00339 HOGENOM HOG000248870 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000248870&db=HOGENOM6 InParanoid P0A796 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A796 IntAct P0A796 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A796* IntEnz 2.7.1.11 {ECO:0000255|HAMAP-Rule:MF_00339} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.11 {ECO:0000255|HAMAP-Rule:MF_00339} InterPro IPR000023 http://www.ebi.ac.uk/interpro/entry/IPR000023 InterPro IPR012003 http://www.ebi.ac.uk/interpro/entry/IPR012003 InterPro IPR012828 http://www.ebi.ac.uk/interpro/entry/IPR012828 InterPro IPR015912 http://www.ebi.ac.uk/interpro/entry/IPR015912 InterPro IPR022953 http://www.ebi.ac.uk/interpro/entry/IPR022953 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3887 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3887 KEGG_Gene eco:b3916 http://www.genome.jp/dbget-bin/www_bget?eco:b3916 KEGG_Orthology KO:K00850 http://www.genome.jp/dbget-bin/www_bget?KO:K00850 KEGG_Pathway ko00010 http://www.genome.jp/kegg-bin/show_pathway?ko00010 KEGG_Pathway ko00030 http://www.genome.jp/kegg-bin/show_pathway?ko00030 KEGG_Pathway ko00051 http://www.genome.jp/kegg-bin/show_pathway?ko00051 KEGG_Pathway ko00052 http://www.genome.jp/kegg-bin/show_pathway?ko00052 KEGG_Pathway ko00680 http://www.genome.jp/kegg-bin/show_pathway?ko00680 KEGG_Reaction rn:R03236 http://www.genome.jp/dbget-bin/www_bget?rn:R03236 KEGG_Reaction rn:R03237 http://www.genome.jp/dbget-bin/www_bget?rn:R03237 KEGG_Reaction rn:R03238 http://www.genome.jp/dbget-bin/www_bget?rn:R03238 KEGG_Reaction rn:R03239 http://www.genome.jp/dbget-bin/www_bget?rn:R03239 KEGG_Reaction rn:R04779 http://www.genome.jp/dbget-bin/www_bget?rn:R04779 MINT MINT-1322275 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1322275 OMA AIITICE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AIITICE PDB 1PFK http://www.ebi.ac.uk/pdbe-srv/view/entry/1PFK PDB 2PFK http://www.ebi.ac.uk/pdbe-srv/view/entry/2PFK PDBsum 1PFK http://www.ebi.ac.uk/pdbsum/1PFK PDBsum 2PFK http://www.ebi.ac.uk/pdbsum/2PFK PRINTS PR00476 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00476 PROSITE PS00433 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00433 PSORT swissprot:PFKA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PFKA_ECOLI PSORT-B swissprot:PFKA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PFKA_ECOLI PSORT2 swissprot:PFKA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PFKA_ECOLI Pfam PF00365 http://pfam.xfam.org/family/PF00365 Phobius swissprot:PFKA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PFKA_ECOLI PhylomeDB P0A796 http://phylomedb.org/?seqid=P0A796 ProteinModelPortal P0A796 http://www.proteinmodelportal.org/query/uniprot/P0A796 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17895580 http://www.ncbi.nlm.nih.gov/pubmed/17895580 PubMed 2527305 http://www.ncbi.nlm.nih.gov/pubmed/2527305 PubMed 2953977 http://www.ncbi.nlm.nih.gov/pubmed/2953977 PubMed 2975709 http://www.ncbi.nlm.nih.gov/pubmed/2975709 PubMed 3158524 http://www.ncbi.nlm.nih.gov/pubmed/3158524 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_418351 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418351 RefSeq WP_000591795 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000591795 SMR P0A796 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A796 STRING 511145.b3916 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3916&targetmode=cogs STRING COG0205 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0205&targetmode=cogs SUPFAM SSF53784 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53784 SWISS-2DPAGE P0A796 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A796 TIGRFAMs TIGR02482 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02482 UniProtKB PFKA_ECOLI http://www.uniprot.org/uniprot/PFKA_ECOLI UniProtKB-AC P0A796 http://www.uniprot.org/uniprot/P0A796 charge swissprot:PFKA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PFKA_ECOLI eggNOG COG0205 http://eggnogapi.embl.de/nog_data/html/tree/COG0205 eggNOG ENOG4105CTQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CTQ epestfind swissprot:PFKA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PFKA_ECOLI garnier swissprot:PFKA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PFKA_ECOLI helixturnhelix swissprot:PFKA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PFKA_ECOLI hmoment swissprot:PFKA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PFKA_ECOLI iep swissprot:PFKA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PFKA_ECOLI inforesidue swissprot:PFKA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PFKA_ECOLI octanol swissprot:PFKA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PFKA_ECOLI pepcoil swissprot:PFKA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PFKA_ECOLI pepdigest swissprot:PFKA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PFKA_ECOLI pepinfo swissprot:PFKA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PFKA_ECOLI pepnet swissprot:PFKA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PFKA_ECOLI pepstats swissprot:PFKA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PFKA_ECOLI pepwheel swissprot:PFKA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PFKA_ECOLI pepwindow swissprot:PFKA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PFKA_ECOLI sigcleave swissprot:PFKA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PFKA_ECOLI ## Database ID URL or Descriptions # AltName FENR_ECOLI DA1 # AltName FENR_ECOLI Flavodoxin reductase # AltName FENR_ECOLI Methyl viologen resistance protein A # BRENDA 1.18.1 2026 # BioGrid 4261115 2 # CATALYTIC ACTIVITY FENR_ECOLI 2 reduced ferredoxin + NADP(+) + H(+) = 2 oxidized ferredoxin + NADPH. # CAUTION PubMed:2834327 authors incorrectly assigned the protein to be part of FPR, the C-terminal of GlpX. {ECO 0000305}. # CDD cd06195 FNR1 # COFACTOR Name=FAD; Xref=ChEBI:CHEBI 57692; # DrugBank DB03147 Flavin adenine dinucleotide # EcoGene EG11518 fpr # FUNCTION FENR_ECOLI Transports electrons between flavodoxin or ferredoxin and NADPH. Involved in the reductive activation of cobalamin- independent methionine synthase, pyruvate formate lyase and anaerobic ribonucleotide reductase. Also protects against superoxide radicals due to methyl viologen in the presence of oxygen. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004324 ferredoxin-NADP+ reductase activity; IDA:EcoCyc. # GO_function GO:0016491 oxidoreductase activity; IMP:EcoliWiki. # GO_function GO:0071949 FAD binding; IDA:EcoCyc. # GO_process GO:0006001 fructose catabolic process; IMP:EcoliWiki. # GO_process GO:0042493 response to drug; IMP:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # IntAct P28861 6 # InterPro IPR001433 OxRdtase_FAD/NAD-bd # InterPro IPR008333 OxRdtase_FAD-bd_dom # InterPro IPR017927 Fd_Rdtase_FAD-bd # InterPro IPR017938 Riboflavin_synthase-like_b-brl # InterPro IPR033892 FNR_bac # KEGG_Brite ko01000 Enzymes # Organism FENR_ECOLI Escherichia coli (strain K12) # PATRIC 32123361 VBIEscCol129921_4041 # PDB 1FDR X-ray; 1.70 A; A=1-248 # PDB 2XNJ X-ray; 1.90 A; A/B=2-247 # PIR S40867 S40867 # PROSITE PS51384 FAD_FR # Pfam PF00175 NAD_binding_1 # Pfam PF00970 FAD_binding_6 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FENR_ECOLI Ferredoxin--NADP reductase # RefSeq NP_418359 NC_000913.3 # RefSeq WP_000796332 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=Z11767; Type=Frameshift; Positions=94, 127; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ferredoxin--NADP reductase type 1 family. {ECO 0000305}. # SIMILARITY Contains 1 FAD-binding FR-type domain. {ECO:0000255|PROSITE-ProRule PRU00716}. # SUBUNIT Monomer. {ECO:0000269|PubMed 9149148}. # SUPFAM SSF63380 SSF63380 # eggNOG COG1018 LUCA # eggNOG ENOG4105DP0 Bacteria BLAST swissprot:FENR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FENR_ECOLI BioCyc ECOL316407:JW3895-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3895-MONOMER BioCyc EcoCyc:FLAVONADPREDUCT-MONOMER http://biocyc.org/getid?id=EcoCyc:FLAVONADPREDUCT-MONOMER BioCyc MetaCyc:FLAVONADPREDUCT-MONOMER http://biocyc.org/getid?id=MetaCyc:FLAVONADPREDUCT-MONOMER COG COG1018 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1018 DOI 10.1006/jmbi.1997.0957 http://dx.doi.org/10.1006/jmbi.1997.0957 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB03147 http://www.drugbank.ca/drugs/DB03147 EC_number EC:1.18.1.2 http://www.genome.jp/dbget-bin/www_bget?EC:1.18.1.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L04757 http://www.ebi.ac.uk/ena/data/view/L04757 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL M19644 http://www.ebi.ac.uk/ena/data/view/M19644 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL Z11767 http://www.ebi.ac.uk/ena/data/view/Z11767 ENZYME 1.18.1.2 http://enzyme.expasy.org/EC/1.18.1.2 EchoBASE EB1480 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1480 EcoGene EG11518 http://www.ecogene.org/geneInfo.php?eg_id=EG11518 EnsemblBacteria AAC76906 http://www.ensemblgenomes.org/id/AAC76906 EnsemblBacteria AAC76906 http://www.ensemblgenomes.org/id/AAC76906 EnsemblBacteria BAE77386 http://www.ensemblgenomes.org/id/BAE77386 EnsemblBacteria BAE77386 http://www.ensemblgenomes.org/id/BAE77386 EnsemblBacteria BAE77386 http://www.ensemblgenomes.org/id/BAE77386 EnsemblBacteria b3924 http://www.ensemblgenomes.org/id/b3924 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004324 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004324 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0071949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071949 GO_process GO:0006001 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006001 GO_process GO:0042493 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 948414 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948414 HOGENOM HOG000265758 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000265758&db=HOGENOM6 InParanoid P28861 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P28861 IntAct P28861 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P28861* IntEnz 1.18.1.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.18.1.2 InterPro IPR001433 http://www.ebi.ac.uk/interpro/entry/IPR001433 InterPro IPR008333 http://www.ebi.ac.uk/interpro/entry/IPR008333 InterPro IPR017927 http://www.ebi.ac.uk/interpro/entry/IPR017927 InterPro IPR017938 http://www.ebi.ac.uk/interpro/entry/IPR017938 InterPro IPR033892 http://www.ebi.ac.uk/interpro/entry/IPR033892 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3895 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3895 KEGG_Gene eco:b3924 http://www.genome.jp/dbget-bin/www_bget?eco:b3924 KEGG_Orthology KO:K00528 http://www.genome.jp/dbget-bin/www_bget?KO:K00528 KEGG_Reaction rn:R10159 http://www.genome.jp/dbget-bin/www_bget?rn:R10159 OMA PFIAGQF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PFIAGQF PDB 1FDR http://www.ebi.ac.uk/pdbe-srv/view/entry/1FDR PDB 2XNJ http://www.ebi.ac.uk/pdbe-srv/view/entry/2XNJ PDBsum 1FDR http://www.ebi.ac.uk/pdbsum/1FDR PDBsum 2XNJ http://www.ebi.ac.uk/pdbsum/2XNJ PROSITE PS51384 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51384 PSORT swissprot:FENR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FENR_ECOLI PSORT-B swissprot:FENR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FENR_ECOLI PSORT2 swissprot:FENR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FENR_ECOLI Pfam PF00175 http://pfam.xfam.org/family/PF00175 Pfam PF00970 http://pfam.xfam.org/family/PF00970 Phobius swissprot:FENR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FENR_ECOLI PhylomeDB P28861 http://phylomedb.org/?seqid=P28861 ProteinModelPortal P28861 http://www.proteinmodelportal.org/query/uniprot/P28861 PubMed 1400248 http://www.ncbi.nlm.nih.gov/pubmed/1400248 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2834327 http://www.ncbi.nlm.nih.gov/pubmed/2834327 PubMed 7961651 http://www.ncbi.nlm.nih.gov/pubmed/7961651 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 8449868 http://www.ncbi.nlm.nih.gov/pubmed/8449868 PubMed 9149148 http://www.ncbi.nlm.nih.gov/pubmed/9149148 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418359 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418359 RefSeq WP_000796332 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000796332 SMR P28861 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P28861 STRING 511145.b3924 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3924&targetmode=cogs STRING COG1018 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1018&targetmode=cogs SUPFAM SSF63380 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63380 UniProtKB FENR_ECOLI http://www.uniprot.org/uniprot/FENR_ECOLI UniProtKB-AC P28861 http://www.uniprot.org/uniprot/P28861 charge swissprot:FENR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FENR_ECOLI eggNOG COG1018 http://eggnogapi.embl.de/nog_data/html/tree/COG1018 eggNOG ENOG4105DP0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DP0 epestfind swissprot:FENR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FENR_ECOLI garnier swissprot:FENR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FENR_ECOLI helixturnhelix swissprot:FENR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FENR_ECOLI hmoment swissprot:FENR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FENR_ECOLI iep swissprot:FENR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FENR_ECOLI inforesidue swissprot:FENR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FENR_ECOLI octanol swissprot:FENR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FENR_ECOLI pepcoil swissprot:FENR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FENR_ECOLI pepdigest swissprot:FENR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FENR_ECOLI pepinfo swissprot:FENR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FENR_ECOLI pepnet swissprot:FENR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FENR_ECOLI pepstats swissprot:FENR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FENR_ECOLI pepwheel swissprot:FENR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FENR_ECOLI pepwindow swissprot:FENR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FENR_ECOLI sigcleave swissprot:FENR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FENR_ECOLI ## Database ID URL or Descriptions # BioGrid 4262296 8 # EcoGene EG13035 ygcG # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR007621 TPM_dom # Organism YGCG_ECOLI Escherichia coli (strain K12) # PATRIC 32120972 VBIEscCol129921_2878 # PIR F65059 F65059 # Pfam PF04536 TPM_phosphatase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGCG_ECOLI UPF0603 protein YgcG # RefSeq NP_417258 NC_000913.3 # RefSeq WP_001268460 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA69288.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the UPF0603 family. {ECO 0000305}. # SUBCELLULAR LOCATION YGCG_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # eggNOG COG1512 LUCA # eggNOG ENOG4105HA9 Bacteria BLAST swissprot:YGCG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGCG_ECOLI BioCyc ECOL316407:JW5445-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5445-MONOMER BioCyc EcoCyc:G7444-MONOMER http://biocyc.org/getid?id=EcoCyc:G7444-MONOMER COG COG1512 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1512 DIP DIP-12123N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12123N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29580 http://www.ebi.ac.uk/ena/data/view/U29580 EchoBASE EB2850 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2850 EcoGene EG13035 http://www.ecogene.org/geneInfo.php?eg_id=EG13035 EnsemblBacteria AAC75820 http://www.ensemblgenomes.org/id/AAC75820 EnsemblBacteria AAC75820 http://www.ensemblgenomes.org/id/AAC75820 EnsemblBacteria BAE76852 http://www.ensemblgenomes.org/id/BAE76852 EnsemblBacteria BAE76852 http://www.ensemblgenomes.org/id/BAE76852 EnsemblBacteria BAE76852 http://www.ensemblgenomes.org/id/BAE76852 EnsemblBacteria b2778 http://www.ensemblgenomes.org/id/b2778 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 945247 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945247 HOGENOM HOG000009544 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009544&db=HOGENOM6 InParanoid P55140 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P55140 IntAct P55140 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P55140* InterPro IPR007621 http://www.ebi.ac.uk/interpro/entry/IPR007621 KEGG_Gene ecj:JW5445 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5445 KEGG_Gene eco:b2778 http://www.genome.jp/dbget-bin/www_bget?eco:b2778 KEGG_Orthology KO:K06872 http://www.genome.jp/dbget-bin/www_bget?KO:K06872 MINT MINT-1304861 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1304861 OMA GWIMALF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GWIMALF PSORT swissprot:YGCG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGCG_ECOLI PSORT-B swissprot:YGCG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGCG_ECOLI PSORT2 swissprot:YGCG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGCG_ECOLI Pfam PF04536 http://pfam.xfam.org/family/PF04536 Phobius swissprot:YGCG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGCG_ECOLI PhylomeDB P55140 http://phylomedb.org/?seqid=P55140 ProteinModelPortal P55140 http://www.proteinmodelportal.org/query/uniprot/P55140 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417258 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417258 RefSeq WP_001268460 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001268460 SMR P55140 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P55140 STRING 511145.b2778 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2778&targetmode=cogs STRING COG1512 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1512&targetmode=cogs UniProtKB YGCG_ECOLI http://www.uniprot.org/uniprot/YGCG_ECOLI UniProtKB-AC P55140 http://www.uniprot.org/uniprot/P55140 charge swissprot:YGCG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGCG_ECOLI eggNOG COG1512 http://eggnogapi.embl.de/nog_data/html/tree/COG1512 eggNOG ENOG4105HA9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105HA9 epestfind swissprot:YGCG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGCG_ECOLI garnier swissprot:YGCG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGCG_ECOLI helixturnhelix swissprot:YGCG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGCG_ECOLI hmoment swissprot:YGCG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGCG_ECOLI iep swissprot:YGCG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGCG_ECOLI inforesidue swissprot:YGCG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGCG_ECOLI octanol swissprot:YGCG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGCG_ECOLI pepcoil swissprot:YGCG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGCG_ECOLI pepdigest swissprot:YGCG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGCG_ECOLI pepinfo swissprot:YGCG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGCG_ECOLI pepnet swissprot:YGCG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGCG_ECOLI pepstats swissprot:YGCG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGCG_ECOLI pepwheel swissprot:YGCG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGCG_ECOLI pepwindow swissprot:YGCG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGCG_ECOLI sigcleave swissprot:YGCG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGCG_ECOLI ## Database ID URL or Descriptions # EcoGene EG14494 shoB # FUNCTION SHOB_ECOLI May be a toxic protein; overexpression causes cessation of growth and rapid membrane depolarization. Overexpression induces stress-response and a number of membrane protein genes. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0012501 programmed cell death; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0008219 cell death # INDUCTION In exponential phase. The ohsC RNA (previously known as ryfC) prevents the toxic effects of shoB overproduction, probably by repressing its translation. A type I toxin antitoxin (TA) system, where expression of the proteinaceous toxin is controlled by an antisense sRNA. {ECO:0000269|PubMed 18710431}. # MISCELLANEOUS SHOB_ECOLI Entirely encoded within a small RNA previously known as ryfB. # Organism SHOB_ECOLI Escherichia coli (strain K12) # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SHOB_ECOLI Small toxic protein ShoB # RefSeq WP_000128776 NZ_LN832404.1 # RefSeq YP_002791251 NC_000913.3 # SUBCELLULAR LOCATION SHOB_ECOLI Membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. BLAST swissprot:SHOB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SHOB_ECOLI BioCyc EcoCyc:MONOMER0-2860 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2860 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2008.06394.x http://dx.doi.org/10.1111/j.1365-2958.2008.06394.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14494 http://www.ecogene.org/geneInfo.php?eg_id=EG14494 EnsemblBacteria ACO60003 http://www.ensemblgenomes.org/id/ACO60003 EnsemblBacteria ACO60003 http://www.ensemblgenomes.org/id/ACO60003 EnsemblBacteria b4687 http://www.ensemblgenomes.org/id/b4687 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0012501 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0012501 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0008219 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008219 GeneID 7751620 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7751620 KEGG_Gene eco:b4687 http://www.genome.jp/dbget-bin/www_bget?eco:b4687 PSORT swissprot:SHOB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SHOB_ECOLI PSORT-B swissprot:SHOB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SHOB_ECOLI PSORT2 swissprot:SHOB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SHOB_ECOLI Phobius swissprot:SHOB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SHOB_ECOLI PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18710431 http://www.ncbi.nlm.nih.gov/pubmed/18710431 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000128776 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000128776 RefSeq YP_002791251 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_002791251 STRING 511145.b4687 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4687&targetmode=cogs UniProtKB SHOB_ECOLI http://www.uniprot.org/uniprot/SHOB_ECOLI UniProtKB-AC C1P611 http://www.uniprot.org/uniprot/C1P611 charge swissprot:SHOB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SHOB_ECOLI epestfind swissprot:SHOB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SHOB_ECOLI garnier swissprot:SHOB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SHOB_ECOLI helixturnhelix swissprot:SHOB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SHOB_ECOLI hmoment swissprot:SHOB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SHOB_ECOLI iep swissprot:SHOB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SHOB_ECOLI inforesidue swissprot:SHOB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SHOB_ECOLI octanol swissprot:SHOB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SHOB_ECOLI pepcoil swissprot:SHOB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SHOB_ECOLI pepdigest swissprot:SHOB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SHOB_ECOLI pepinfo swissprot:SHOB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SHOB_ECOLI pepnet swissprot:SHOB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SHOB_ECOLI pepstats swissprot:SHOB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SHOB_ECOLI pepwheel swissprot:SHOB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SHOB_ECOLI pepwindow swissprot:SHOB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SHOB_ECOLI sigcleave swissprot:SHOB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SHOB_ECOLI ## Database ID URL or Descriptions # BioGrid 4262052 10 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG13036 ygeF # Organism YGEF_ECOLI Escherichia coli (strain K12) # PIR C65068 C65068 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGEF_ECOLI Putative uncharacterized protein YgeF BLAST swissprot:YGEF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGEF_ECOLI BioCyc ECOL316407:JW2818-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2818-MONOMER BioCyc EcoCyc:G7470-MONOMER http://biocyc.org/getid?id=EcoCyc:G7470-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 EchoBASE EB2851 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2851 EcoGene EG13036 http://www.ecogene.org/geneInfo.php?eg_id=EG13036 EnsemblBacteria BAE76919 http://www.ensemblgenomes.org/id/BAE76919 EnsemblBacteria BAE76919 http://www.ensemblgenomes.org/id/BAE76919 EnsemblBacteria BAE76919 http://www.ensemblgenomes.org/id/BAE76919 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv HOGENOM HOG000009774 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009774&db=HOGENOM6 KEGG_Gene ecj:JW2818 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2818 OMA EGKYLTH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EGKYLTH PSORT swissprot:YGEF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGEF_ECOLI PSORT-B swissprot:YGEF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGEF_ECOLI PSORT2 swissprot:YGEF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGEF_ECOLI Phobius swissprot:YGEF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGEF_ECOLI ProteinModelPortal Q46786 http://www.proteinmodelportal.org/query/uniprot/Q46786 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 STRING 316407.85675666 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85675666&targetmode=cogs UniProtKB YGEF_ECOLI http://www.uniprot.org/uniprot/YGEF_ECOLI UniProtKB-AC Q46786 http://www.uniprot.org/uniprot/Q46786 charge swissprot:YGEF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGEF_ECOLI epestfind swissprot:YGEF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGEF_ECOLI garnier swissprot:YGEF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGEF_ECOLI helixturnhelix swissprot:YGEF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGEF_ECOLI hmoment swissprot:YGEF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGEF_ECOLI iep swissprot:YGEF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGEF_ECOLI inforesidue swissprot:YGEF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGEF_ECOLI octanol swissprot:YGEF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGEF_ECOLI pepcoil swissprot:YGEF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGEF_ECOLI pepdigest swissprot:YGEF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGEF_ECOLI pepinfo swissprot:YGEF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGEF_ECOLI pepnet swissprot:YGEF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGEF_ECOLI pepstats swissprot:YGEF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGEF_ECOLI pepwheel swissprot:YGEF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGEF_ECOLI pepwindow swissprot:YGEF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGEF_ECOLI sigcleave swissprot:YGEF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGEF_ECOLI ## Database ID URL or Descriptions # AltName CYSB_ECOLI Cys regulon transcriptional activator # BioGrid 4260138 21 # EcoGene EG10184 cysB # FUNCTION CYSB_ECOLI This protein is a positive regulator of gene expression for the cysteine regulon, a system of 10 or more loci involved in the biosynthesis of L-cysteine from inorganic sulfate. The inducer for CysB is N-acetylserine. CysB inhibits its own transcription. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_function GO:0042802 identical protein binding; IMP:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0008652 cellular amino acid biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0019344 cysteine biosynthetic process; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # IntAct P0A9F3 9 # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR005119 LysR_subst-bd # InterPro IPR011991 WHTH_DNA-bd_dom # KEGG_Brite ko03000 Transcription factors # Organism CYSB_ECOLI Escherichia coli (strain K12) # PATRIC 32117808 VBIEscCol129921_1324 # PIR A26695 RGECCB # PRINTS PR00039 HTHLYSR # PROSITE PS50931 HTH_LYSR # Pfam PF00126 HTH_1 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CYSB_ECOLI HTH-type transcriptional regulator CysB # RefSeq NP_415791 NC_000913.3 # RefSeq WP_000776253 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lysR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00253}. # SUBCELLULAR LOCATION CYSB_ECOLI Cytoplasm. # SUBUNIT Homotetramer. {ECO 0000250}. # SUPFAM SSF46785 SSF46785 # eggNOG ENOG4107R11 Bacteria # eggNOG ENOG410XP61 LUCA BLAST swissprot:CYSB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CYSB_ECOLI BioCyc ECOL316407:JW1267-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1267-MONOMER BioCyc EcoCyc:PD00232 http://biocyc.org/getid?id=EcoCyc:PD00232 BioCyc MetaCyc:PD00232 http://biocyc.org/getid?id=MetaCyc:PD00232 COG COG0583 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0583 DIP DIP-36048N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36048N DOI 10.1016/0006-291X(90)90617-V http://dx.doi.org/10.1016/0006-291X(90)90617-V DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1111/j.1432-1033.1992.tb16673.x http://dx.doi.org/10.1111/j.1432-1033.1992.tb16673.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M15041 http://www.ebi.ac.uk/ena/data/view/M15041 EMBL M34332 http://www.ebi.ac.uk/ena/data/view/M34332 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X60293 http://www.ebi.ac.uk/ena/data/view/X60293 EchoBASE EB0181 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0181 EcoGene EG10184 http://www.ecogene.org/geneInfo.php?eg_id=EG10184 EnsemblBacteria AAC74357 http://www.ensemblgenomes.org/id/AAC74357 EnsemblBacteria AAC74357 http://www.ensemblgenomes.org/id/AAC74357 EnsemblBacteria BAA14827 http://www.ensemblgenomes.org/id/BAA14827 EnsemblBacteria BAA14827 http://www.ensemblgenomes.org/id/BAA14827 EnsemblBacteria BAA14827 http://www.ensemblgenomes.org/id/BAA14827 EnsemblBacteria b1275 http://www.ensemblgenomes.org/id/b1275 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0008652 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008652 GO_process GO:0019344 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019344 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 945771 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945771 HOGENOM HOG000260068 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260068&db=HOGENOM6 InParanoid P0A9F3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9F3 IntAct P0A9F3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9F3* InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW1267 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1267 KEGG_Gene eco:b1275 http://www.genome.jp/dbget-bin/www_bget?eco:b1275 KEGG_Orthology KO:K13634 http://www.genome.jp/dbget-bin/www_bget?KO:K13634 MINT MINT-1276319 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1276319 OMA DEAFSHR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DEAFSHR PRINTS PR00039 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00039 PROSITE PS50931 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50931 PSORT swissprot:CYSB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CYSB_ECOLI PSORT-B swissprot:CYSB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CYSB_ECOLI PSORT2 swissprot:CYSB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CYSB_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:CYSB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CYSB_ECOLI PhylomeDB P0A9F3 http://phylomedb.org/?seqid=P0A9F3 ProteinModelPortal P0A9F3 http://www.proteinmodelportal.org/query/uniprot/P0A9F3 PubMed 1541275 http://www.ncbi.nlm.nih.gov/pubmed/1541275 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2182030 http://www.ncbi.nlm.nih.gov/pubmed/2182030 PubMed 3032952 http://www.ncbi.nlm.nih.gov/pubmed/3032952 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415791 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415791 RefSeq WP_000776253 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000776253 SMR P0A9F3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9F3 STRING 511145.b1275 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1275&targetmode=cogs STRING COG0583 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0583&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB CYSB_ECOLI http://www.uniprot.org/uniprot/CYSB_ECOLI UniProtKB-AC P0A9F3 http://www.uniprot.org/uniprot/P0A9F3 charge swissprot:CYSB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CYSB_ECOLI eggNOG ENOG4107R11 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107R11 eggNOG ENOG410XP61 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XP61 epestfind swissprot:CYSB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CYSB_ECOLI garnier swissprot:CYSB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CYSB_ECOLI helixturnhelix swissprot:CYSB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CYSB_ECOLI hmoment swissprot:CYSB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CYSB_ECOLI iep swissprot:CYSB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CYSB_ECOLI inforesidue swissprot:CYSB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CYSB_ECOLI octanol swissprot:CYSB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CYSB_ECOLI pepcoil swissprot:CYSB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CYSB_ECOLI pepdigest swissprot:CYSB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CYSB_ECOLI pepinfo swissprot:CYSB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CYSB_ECOLI pepnet swissprot:CYSB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CYSB_ECOLI pepstats swissprot:CYSB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CYSB_ECOLI pepwheel swissprot:CYSB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CYSB_ECOLI pepwindow swissprot:CYSB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CYSB_ECOLI sigcleave swissprot:CYSB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CYSB_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES DHE4_ECOLI Kinetic parameters KM=40 uM for NADPH {ECO 0000269|PubMed 235298, ECO 0000269|PubMed 241744}; KM=42 uM for NADP {ECO 0000269|PubMed 235298, ECO 0000269|PubMed 241744}; KM=640 uM for 2-oxoglutarate {ECO 0000269|PubMed 235298, ECO 0000269|PubMed 241744}; KM=1100 uM for ammonia {ECO 0000269|PubMed 235298, ECO 0000269|PubMed 241744}; pH dependence Optimum pH is 8 and 9 for the reductive amination and for the oxidative deamination, respectively. The enzyme remains active when heat treated or when left at room temperature for several months but is inactivated by freezing. {ECO 0000269|PubMed 235298, ECO 0000269|PubMed 241744}; # BRENDA 1.4.1 2026 # BioGrid 4260322 621 # CATALYTIC ACTIVITY DHE4_ECOLI L-glutamate + H(2)O + NADP(+) = 2-oxoglutarate + NH(3) + NADPH. # CDD cd05313 NAD_bind_2_Glu_DH # ENZYME REGULATION Competitively inhibited by homoserine and by glutamine. {ECO:0000269|PubMed 235298}. # EcoGene EG10372 gdhA # FUNCTION DHE4_ECOLI Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. {ECO 0000269|PubMed 235298, ECO 0000269|PubMed 241744}. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004352 glutamate dehydrogenase (NAD+) activity; IEA:InterPro. # GO_function GO:0004354 glutamate dehydrogenase (NADP+) activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IPI:EcoCyc. # GO_process GO:0006520 cellular amino acid metabolic process; IEA:InterPro. # GO_process GO:0006537 glutamate biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.720 -; 1. # INDUCTION DHE4_ECOLI Induced by growth on glucose and ammonia. # InterPro IPR006095 Glu/Leu/Phe/Val_DH # InterPro IPR006096 Glu/Leu/Phe/Val_DH_C # InterPro IPR006097 Glu/Leu/Phe/Val_DH_dimer_dom # InterPro IPR014362 Glu_DH # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR033524 Glu/Leu/Phe/Val_DH_AS # InterPro IPR033922 NAD_bind_Glu_DH # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00250 Alanine, aspartate and glutamate metabolism # KEGG_Pathway ko00330 Arginine and proline metabolism # KEGG_Pathway ko00910 Nitrogen metabolism # Organism DHE4_ECOLI Escherichia coli (strain K12) # PATRIC 32118833 VBIEscCol129921_1834 # PDB 2YFH X-ray; 2.70 A; A/B/C/D/E/F=202-405 # PDB 3SBO X-ray; 3.20 A; A/B/C/D/E/F=1-447 # PDB 4BHT X-ray; 2.50 A; A/B/C/D/E/F=1-447 # PIR A00382 DEECEN # PIRSF PIRSF000185 Glu_DH # PRINTS PR00082 GLFDHDRGNASE # PROSITE PS00074 GLFV_DEHYDROGENASE # Pfam PF00208 ELFV_dehydrog # Pfam PF02812 ELFV_dehydrog_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DHE4_ECOLI NADP-specific glutamate dehydrogenase # RefSeq NP_416275 NC_000913.3 # RefSeq WP_000373021 NZ_LN832404.1 # SIMILARITY Belongs to the Glu/Leu/Phe/Val dehydrogenases family. {ECO 0000305}. # SMART SM00839 ELFV_dehydrog # SUBUNIT Homohexamer. {ECO:0000269|PubMed 241744, ECO:0000269|Ref.12}. # SUPFAM SSF51735 SSF51735 # eggNOG COG0334 LUCA # eggNOG ENOG4105D82 Bacteria BLAST swissprot:DHE4_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DHE4_ECOLI BioCyc ECOL316407:JW1750-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1750-MONOMER BioCyc EcoCyc:GDHA-MONOMER http://biocyc.org/getid?id=EcoCyc:GDHA-MONOMER BioCyc MetaCyc:GDHA-MONOMER http://biocyc.org/getid?id=MetaCyc:GDHA-MONOMER COG COG0334 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0334 DIP DIP-9756N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9756N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1007/BF00277068 http://dx.doi.org/10.1007/BF00277068 DOI 10.1016/0005-2744(75)90304-6 http://dx.doi.org/10.1016/0005-2744(75)90304-6 DOI 10.1016/0378-1119(84)90140-9 http://dx.doi.org/10.1016/0378-1119(84)90140-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/11.15.5257 http://dx.doi.org/10.1093/nar/11.15.5257 DOI 10.1093/protein/2.2.147 http://dx.doi.org/10.1093/protein/2.2.147 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pone.0032498 http://dx.doi.org/10.1371/journal.pone.0032498 EC_number EC:1.4.1.4 http://www.genome.jp/dbget-bin/www_bget?EC:1.4.1.4 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01615 http://www.ebi.ac.uk/ena/data/view/J01615 EMBL K02499 http://www.ebi.ac.uk/ena/data/view/K02499 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.4.1.4 http://enzyme.expasy.org/EC/1.4.1.4 EchoBASE EB0367 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0367 EcoGene EG10372 http://www.ecogene.org/geneInfo.php?eg_id=EG10372 EnsemblBacteria AAC74831 http://www.ensemblgenomes.org/id/AAC74831 EnsemblBacteria AAC74831 http://www.ensemblgenomes.org/id/AAC74831 EnsemblBacteria BAA15550 http://www.ensemblgenomes.org/id/BAA15550 EnsemblBacteria BAA15550 http://www.ensemblgenomes.org/id/BAA15550 EnsemblBacteria BAA15550 http://www.ensemblgenomes.org/id/BAA15550 EnsemblBacteria b1761 http://www.ensemblgenomes.org/id/b1761 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004352 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004352 GO_function GO:0004354 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004354 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GO_process GO:0006537 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006537 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 946802 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946802 HOGENOM HOG000243799 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000243799&db=HOGENOM6 InParanoid P00370 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00370 IntAct P00370 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00370* IntEnz 1.4.1.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.4.1.4 InterPro IPR006095 http://www.ebi.ac.uk/interpro/entry/IPR006095 InterPro IPR006096 http://www.ebi.ac.uk/interpro/entry/IPR006096 InterPro IPR006097 http://www.ebi.ac.uk/interpro/entry/IPR006097 InterPro IPR014362 http://www.ebi.ac.uk/interpro/entry/IPR014362 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR033524 http://www.ebi.ac.uk/interpro/entry/IPR033524 InterPro IPR033922 http://www.ebi.ac.uk/interpro/entry/IPR033922 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1750 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1750 KEGG_Gene eco:b1761 http://www.genome.jp/dbget-bin/www_bget?eco:b1761 KEGG_Orthology KO:K00262 http://www.genome.jp/dbget-bin/www_bget?KO:K00262 KEGG_Pathway ko00250 http://www.genome.jp/kegg-bin/show_pathway?ko00250 KEGG_Pathway ko00330 http://www.genome.jp/kegg-bin/show_pathway?ko00330 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Reaction rn:R00243 http://www.genome.jp/dbget-bin/www_bget?rn:R00243 KEGG_Reaction rn:R00248 http://www.genome.jp/dbget-bin/www_bget?rn:R00248 OMA VPWVDDA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VPWVDDA PDB 2YFH http://www.ebi.ac.uk/pdbe-srv/view/entry/2YFH PDB 3SBO http://www.ebi.ac.uk/pdbe-srv/view/entry/3SBO PDB 4BHT http://www.ebi.ac.uk/pdbe-srv/view/entry/4BHT PDBsum 2YFH http://www.ebi.ac.uk/pdbsum/2YFH PDBsum 3SBO http://www.ebi.ac.uk/pdbsum/3SBO PDBsum 4BHT http://www.ebi.ac.uk/pdbsum/4BHT PRINTS PR00082 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00082 PROSITE PS00074 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00074 PSORT swissprot:DHE4_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DHE4_ECOLI PSORT-B swissprot:DHE4_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DHE4_ECOLI PSORT2 swissprot:DHE4_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DHE4_ECOLI Pfam PF00208 http://pfam.xfam.org/family/PF00208 Pfam PF02812 http://pfam.xfam.org/family/PF02812 Phobius swissprot:DHE4_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DHE4_ECOLI PhylomeDB P00370 http://phylomedb.org/?seqid=P00370 ProteinModelPortal P00370 http://www.proteinmodelportal.org/query/uniprot/P00370 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22393408 http://www.ncbi.nlm.nih.gov/pubmed/22393408 PubMed 235298 http://www.ncbi.nlm.nih.gov/pubmed/235298 PubMed 241744 http://www.ncbi.nlm.nih.gov/pubmed/241744 PubMed 3149742 http://www.ncbi.nlm.nih.gov/pubmed/3149742 PubMed 6308576 http://www.ncbi.nlm.nih.gov/pubmed/6308576 PubMed 6373501 http://www.ncbi.nlm.nih.gov/pubmed/6373501 PubMed 8355660 http://www.ncbi.nlm.nih.gov/pubmed/8355660 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_416275 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416275 RefSeq WP_000373021 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000373021 SMART SM00839 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00839 SMR P00370 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00370 STRING 511145.b1761 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1761&targetmode=cogs STRING COG0334 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0334&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 SWISS-2DPAGE P00370 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P00370 UniProtKB DHE4_ECOLI http://www.uniprot.org/uniprot/DHE4_ECOLI UniProtKB-AC P00370 http://www.uniprot.org/uniprot/P00370 charge swissprot:DHE4_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DHE4_ECOLI eggNOG COG0334 http://eggnogapi.embl.de/nog_data/html/tree/COG0334 eggNOG ENOG4105D82 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D82 epestfind swissprot:DHE4_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DHE4_ECOLI garnier swissprot:DHE4_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DHE4_ECOLI helixturnhelix swissprot:DHE4_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DHE4_ECOLI hmoment swissprot:DHE4_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DHE4_ECOLI iep swissprot:DHE4_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DHE4_ECOLI inforesidue swissprot:DHE4_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DHE4_ECOLI octanol swissprot:DHE4_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DHE4_ECOLI pepcoil swissprot:DHE4_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DHE4_ECOLI pepdigest swissprot:DHE4_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DHE4_ECOLI pepinfo swissprot:DHE4_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DHE4_ECOLI pepnet swissprot:DHE4_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DHE4_ECOLI pepstats swissprot:DHE4_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DHE4_ECOLI pepwheel swissprot:DHE4_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DHE4_ECOLI pepwindow swissprot:DHE4_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DHE4_ECOLI sigcleave swissprot:DHE4_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DHE4_ECOLI ## Database ID URL or Descriptions # BioGrid 4261503 12 # EcoGene EG11606 kch # FUNCTION KCH_ECOLI K(+)-specific ion channel. May play a role in the defense against osmotic shock. {ECO 0000269|PubMed 12912904, ECO 0000269|PubMed 8170937}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0006813 potassium ion transport; IMP:EcoCyc. # GO_process GO:0051289 protein homotetramerization; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0006810 transport # Gene3D 3.40.50.720 -; 1. # InterPro IPR003148 RCK_N # InterPro IPR013099 K_chnl_dom # InterPro IPR016040 NAD(P)-bd_dom # KEGG_Brite ko02000 Transporters # Organism KCH_ECOLI Escherichia coli (strain K12) # PATRIC 32117760 VBIEscCol129921_1300 # PDB 1ID1 X-ray; 2.40 A; A/B=241-393 # PIR A55252 A55252 # PIR T45507 T45507 # PROSITE PS51201 RCK_N # Pfam PF02254 TrkA_N # Pfam PF07885 Ion_trans_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName KCH_ECOLI Voltage-gated potassium channel Kch # RefSeq NP_415766 NC_000913.3 # RefSeq WP_001295624 NZ_LN832404.1 # SIMILARITY Belongs to the potassium channel family. {ECO 0000305}. # SIMILARITY Contains 1 RCK N-terminal domain. {ECO:0000255|PROSITE-ProRule PRU00543}. # SUBCELLULAR LOCATION KCH_ECOLI Cell inner membrane {ECO 0000269|PubMed 8824224}; Multi-pass membrane protein {ECO 0000269|PubMed 8824224}. # SUBUNIT KCH_ECOLI Dimer. # SUPFAM SSF51735 SSF51735 # TCDB 1.A.1.13 the voltage-gated ion channel (vic) superfamily # eggNOG COG1226 LUCA # eggNOG ENOG4107SVH Bacteria BLAST swissprot:KCH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:KCH_ECOLI BioCyc ECOL316407:JW1242-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1242-MONOMER BioCyc EcoCyc:KCH-MONOMER http://biocyc.org/getid?id=EcoCyc:KCH-MONOMER BioCyc MetaCyc:KCH-MONOMER http://biocyc.org/getid?id=MetaCyc:KCH-MONOMER COG COG1226 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1226 DIP DIP-10055N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10055N DOI 10.1016/S0896-6273(01)00236-7 http://dx.doi.org/10.1016/S0896-6273(01)00236-7 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.91.9.3510 http://dx.doi.org/10.1073/pnas.91.9.3510 DOI 10.1074/jbc.271.42.25912 http://dx.doi.org/10.1074/jbc.271.42.25912 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/emboj/cdg409 http://dx.doi.org/10.1093/emboj/cdg409 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L12044 http://www.ebi.ac.uk/ena/data/view/L12044 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U24195 http://www.ebi.ac.uk/ena/data/view/U24195 EMBL U24196 http://www.ebi.ac.uk/ena/data/view/U24196 EMBL U24197 http://www.ebi.ac.uk/ena/data/view/U24197 EMBL U24198 http://www.ebi.ac.uk/ena/data/view/U24198 EMBL U24199 http://www.ebi.ac.uk/ena/data/view/U24199 EMBL U24200 http://www.ebi.ac.uk/ena/data/view/U24200 EMBL U24201 http://www.ebi.ac.uk/ena/data/view/U24201 EMBL U24202 http://www.ebi.ac.uk/ena/data/view/U24202 EMBL U24203 http://www.ebi.ac.uk/ena/data/view/U24203 EMBL U24204 http://www.ebi.ac.uk/ena/data/view/U24204 EMBL U24205 http://www.ebi.ac.uk/ena/data/view/U24205 EMBL U24206 http://www.ebi.ac.uk/ena/data/view/U24206 EchoBASE EB1563 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1563 EcoGene EG11606 http://www.ecogene.org/geneInfo.php?eg_id=EG11606 EnsemblBacteria AAC74332 http://www.ensemblgenomes.org/id/AAC74332 EnsemblBacteria AAC74332 http://www.ensemblgenomes.org/id/AAC74332 EnsemblBacteria BAA14782 http://www.ensemblgenomes.org/id/BAA14782 EnsemblBacteria BAA14782 http://www.ensemblgenomes.org/id/BAA14782 EnsemblBacteria BAA14782 http://www.ensemblgenomes.org/id/BAA14782 EnsemblBacteria b1250 http://www.ensemblgenomes.org/id/b1250 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0006813 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813 GO_process GO:0051289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051289 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 945841 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945841 InParanoid P31069 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31069 IntAct P31069 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31069* InterPro IPR003148 http://www.ebi.ac.uk/interpro/entry/IPR003148 InterPro IPR013099 http://www.ebi.ac.uk/interpro/entry/IPR013099 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1242 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1242 KEGG_Gene eco:b1250 http://www.genome.jp/dbget-bin/www_bget?eco:b1250 KEGG_Orthology KO:K10716 http://www.genome.jp/dbget-bin/www_bget?KO:K10716 OMA FEGINTI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FEGINTI PDB 1ID1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ID1 PDBsum 1ID1 http://www.ebi.ac.uk/pdbsum/1ID1 PROSITE PS51201 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51201 PSORT swissprot:KCH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:KCH_ECOLI PSORT-B swissprot:KCH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:KCH_ECOLI PSORT2 swissprot:KCH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:KCH_ECOLI Pfam PF02254 http://pfam.xfam.org/family/PF02254 Pfam PF07885 http://pfam.xfam.org/family/PF07885 Phobius swissprot:KCH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:KCH_ECOLI PhylomeDB P31069 http://phylomedb.org/?seqid=P31069 ProteinModelPortal P31069 http://www.proteinmodelportal.org/query/uniprot/P31069 PubMed 11301020 http://www.ncbi.nlm.nih.gov/pubmed/11301020 PubMed 12912904 http://www.ncbi.nlm.nih.gov/pubmed/12912904 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8170937 http://www.ncbi.nlm.nih.gov/pubmed/8170937 PubMed 8824224 http://www.ncbi.nlm.nih.gov/pubmed/8824224 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415766 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415766 RefSeq WP_001295624 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295624 SMR P31069 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31069 STRING 511145.b1250 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1250&targetmode=cogs STRING COG1226 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1226&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 TCDB 1.A.1.13 http://www.tcdb.org/search/result.php?tc=1.A.1.13 UniProtKB KCH_ECOLI http://www.uniprot.org/uniprot/KCH_ECOLI UniProtKB-AC P31069 http://www.uniprot.org/uniprot/P31069 charge swissprot:KCH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:KCH_ECOLI eggNOG COG1226 http://eggnogapi.embl.de/nog_data/html/tree/COG1226 eggNOG ENOG4107SVH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107SVH epestfind swissprot:KCH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:KCH_ECOLI garnier swissprot:KCH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:KCH_ECOLI helixturnhelix swissprot:KCH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCH_ECOLI hmoment swissprot:KCH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:KCH_ECOLI iep swissprot:KCH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:KCH_ECOLI inforesidue swissprot:KCH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:KCH_ECOLI octanol swissprot:KCH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:KCH_ECOLI pepcoil swissprot:KCH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:KCH_ECOLI pepdigest swissprot:KCH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:KCH_ECOLI pepinfo swissprot:KCH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:KCH_ECOLI pepnet swissprot:KCH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:KCH_ECOLI pepstats swissprot:KCH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:KCH_ECOLI pepwheel swissprot:KCH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:KCH_ECOLI pepwindow swissprot:KCH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:KCH_ECOLI sigcleave swissprot:KCH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:KCH_ECOLI ## Database ID URL or Descriptions # AltName QUED_ECOLI Queuosine biosynthesis protein QueD # BRENDA 4.1.2.50 2026 # CATALYTIC ACTIVITY 7,8-dihydroneopterin 3'-triphosphate + H(2)O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate. {ECO:0000269|PubMed 19231875}. # COFACTOR QUED_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 19231875}; Note=Binds 1 zinc ion per subunit. {ECO 0000269|PubMed 19231875}; # EcoGene EG13120 queD # FUNCTION QUED_ECOLI Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde. Can also convert 6-pyruvoyltetrahydropterin (PPH4) and sepiapterin to CPH4; these 2 compounds are probably intermediates in the reaction from H2NTP. {ECO 0000269|PubMed 19231875}. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0070497 6-carboxy-5,6,7,8-tetrahydropterin synthase activity; IDA:EcoCyc. # GO_process GO:0008616 queuosine biosynthetic process; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # IntAct P65870 3 # InterPro IPR007115 6-PTP_synth/QueD # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # KEGG_Pathway ko00790 Folate biosynthesis # MISCELLANEOUS The active site is at the interface between 2 subunits. The proton acceptor Cys is on one subunit, and the charge relay system is on the other subunit (By similarity). {ECO 0000250}. # Organism QUED_ECOLI Escherichia coli (strain K12) # PANTHER PTHR12589 PTHR12589 # PATHWAY QUED_ECOLI Purine metabolism; 7-cyano-7-deazaguanine biosynthesis. # PATRIC 32120942 VBIEscCol129921_2863 # PDB 3QN0 X-ray; 2.34 A; A/B/C/D/E/F=1-121 # PDB 3QN9 X-ray; 2.93 A; A/B=1-121 # PDB 3QNA X-ray; 2.50 A; A/B/C/D/E/F=1-121 # PDB 4NTK X-ray; 1.60 A; A/B/C/D/E/F=1-121 # PDB 4NTM X-ray; 2.05 A; A/B/C/D/E/F=1-121 # PDB 4NTN X-ray; 1.99 A; A/B/C/D/E/F=1-121 # PIR A65058 A65058 # PIRSF PIRSF006113 PTP_synth # Pfam PF01242 PTPS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName QUED_ECOLI 6-carboxy-5,6,7,8-tetrahydropterin synthase # RefSeq NP_417245 NC_000913.3 # SIMILARITY Belongs to the PTPS family. QueD subfamily. {ECO 0000305}. # TIGRFAMs TIGR00039 6PTHBS # TIGRFAMs TIGR03367 queuosine_QueD # eggNOG COG0720 LUCA # eggNOG ENOG4107ZIF Bacteria BLAST swissprot:QUED_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:QUED_ECOLI BioCyc ECOL316407:JW2735-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2735-MONOMER BioCyc EcoCyc:G7431-MONOMER http://biocyc.org/getid?id=EcoCyc:G7431-MONOMER BioCyc MetaCyc:G7431-MONOMER http://biocyc.org/getid?id=MetaCyc:G7431-MONOMER COG COG0720 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0720 DOI 10.1021/bi9001437 http://dx.doi.org/10.1021/bi9001437 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.1.2.50 http://www.genome.jp/dbget-bin/www_bget?EC:4.1.2.50 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 ENZYME 4.1.2.50 http://enzyme.expasy.org/EC/4.1.2.50 EchoBASE EB2921 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2921 EcoGene EG13120 http://www.ecogene.org/geneInfo.php?eg_id=EG13120 EnsemblBacteria AAC75807 http://www.ensemblgenomes.org/id/AAC75807 EnsemblBacteria AAC75807 http://www.ensemblgenomes.org/id/AAC75807 EnsemblBacteria BAE76842 http://www.ensemblgenomes.org/id/BAE76842 EnsemblBacteria BAE76842 http://www.ensemblgenomes.org/id/BAE76842 EnsemblBacteria BAE76842 http://www.ensemblgenomes.org/id/BAE76842 EnsemblBacteria b2765 http://www.ensemblgenomes.org/id/b2765 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0070497 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070497 GO_process GO:0008616 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008616 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 945123 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945123 HOGENOM HOG000225067 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000225067&db=HOGENOM6 InParanoid P65870 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P65870 IntAct P65870 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P65870* IntEnz 4.1.2.50 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.2.50 InterPro IPR007115 http://www.ebi.ac.uk/interpro/entry/IPR007115 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW2735 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2735 KEGG_Gene eco:b2765 http://www.genome.jp/dbget-bin/www_bget?eco:b2765 KEGG_Orthology KO:K01737 http://www.genome.jp/dbget-bin/www_bget?KO:K01737 KEGG_Pathway ko00790 http://www.genome.jp/kegg-bin/show_pathway?ko00790 KEGG_Reaction rn:R04286 http://www.genome.jp/dbget-bin/www_bget?rn:R04286 MINT MINT-1299113 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1299113 OMA PNVPETH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PNVPETH PANTHER PTHR12589 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12589 PDB 3QN0 http://www.ebi.ac.uk/pdbe-srv/view/entry/3QN0 PDB 3QN9 http://www.ebi.ac.uk/pdbe-srv/view/entry/3QN9 PDB 3QNA http://www.ebi.ac.uk/pdbe-srv/view/entry/3QNA PDB 4NTK http://www.ebi.ac.uk/pdbe-srv/view/entry/4NTK PDB 4NTM http://www.ebi.ac.uk/pdbe-srv/view/entry/4NTM PDB 4NTN http://www.ebi.ac.uk/pdbe-srv/view/entry/4NTN PDBsum 3QN0 http://www.ebi.ac.uk/pdbsum/3QN0 PDBsum 3QN9 http://www.ebi.ac.uk/pdbsum/3QN9 PDBsum 3QNA http://www.ebi.ac.uk/pdbsum/3QNA PDBsum 4NTK http://www.ebi.ac.uk/pdbsum/4NTK PDBsum 4NTM http://www.ebi.ac.uk/pdbsum/4NTM PDBsum 4NTN http://www.ebi.ac.uk/pdbsum/4NTN PSORT swissprot:QUED_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:QUED_ECOLI PSORT-B swissprot:QUED_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:QUED_ECOLI PSORT2 swissprot:QUED_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:QUED_ECOLI Pfam PF01242 http://pfam.xfam.org/family/PF01242 Phobius swissprot:QUED_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:QUED_ECOLI PhylomeDB P65870 http://phylomedb.org/?seqid=P65870 ProteinModelPortal P65870 http://www.proteinmodelportal.org/query/uniprot/P65870 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19231875 http://www.ncbi.nlm.nih.gov/pubmed/19231875 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417245 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417245 SMR P65870 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P65870 STRING 511145.b2765 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2765&targetmode=cogs STRING COG0720 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0720&targetmode=cogs TIGRFAMs TIGR00039 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00039 TIGRFAMs TIGR03367 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03367 UniProtKB QUED_ECOLI http://www.uniprot.org/uniprot/QUED_ECOLI UniProtKB-AC P65870 http://www.uniprot.org/uniprot/P65870 charge swissprot:QUED_ECOLI http://rest.g-language.org/emboss/charge/swissprot:QUED_ECOLI eggNOG COG0720 http://eggnogapi.embl.de/nog_data/html/tree/COG0720 eggNOG ENOG4107ZIF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107ZIF epestfind swissprot:QUED_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:QUED_ECOLI garnier swissprot:QUED_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:QUED_ECOLI helixturnhelix swissprot:QUED_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:QUED_ECOLI hmoment swissprot:QUED_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:QUED_ECOLI iep swissprot:QUED_ECOLI http://rest.g-language.org/emboss/iep/swissprot:QUED_ECOLI inforesidue swissprot:QUED_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:QUED_ECOLI octanol swissprot:QUED_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:QUED_ECOLI pepcoil swissprot:QUED_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:QUED_ECOLI pepdigest swissprot:QUED_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:QUED_ECOLI pepinfo swissprot:QUED_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:QUED_ECOLI pepnet swissprot:QUED_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:QUED_ECOLI pepstats swissprot:QUED_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:QUED_ECOLI pepwheel swissprot:QUED_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:QUED_ECOLI pepwindow swissprot:QUED_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:QUED_ECOLI sigcleave swissprot:QUED_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:QUED_ECOLI ## Database ID URL or Descriptions # AltName METE_ECOLI Cobalamin-independent methionine synthase # AltName METE_ECOLI Methionine synthase, vitamin-B12 independent isozyme # BRENDA 2.1.1.14 2026 # BioGrid 4259477 9 # CATALYTIC ACTIVITY METE_ECOLI 5-methyltetrahydropteroyltri-L-glutamate + L- homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine. # COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI 29105; Note=Binds 1 zinc ion per subunit.; # EcoGene EG10584 metE # FUNCTION METE_ECOLI Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation. # GO_component GO:0005576 extracellular region; IBA:GO_Central. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003871 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IEA:InterPro. # GO_function GO:0008276 protein methyltransferase activity; IDA:BHF-UCL. # GO_function GO:0008705 methionine synthase activity; IDA:BHF-UCL. # GO_process GO:0009086 methionine biosynthetic process; IDA:BHF-UCL. # GO_process GO:0035999 tetrahydrofolate interconversion; IDA:BHF-UCL. # GO_process GO:0050667 homocysteine metabolic process; IDA:BHF-UCL. # GOslim_component GO:0005576 extracellular region # GOslim_component GO:0005829 cytosol # GOslim_function GO:0008168 methyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # HAMAP MF_00172 Meth_synth # INTERACTION METE_ECOLI P03018 uvrD; NbExp=2; IntAct=EBI-551247, EBI-559573; # IntAct P25665 11 # InterPro IPR002629 Met_Synth_C/arc # InterPro IPR006276 Cobalamin-indep_Met_synthase # InterPro IPR013215 Cbl-indep_Met_Synth_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00270 Cysteine and methionine metabolism # KEGG_Pathway ko00450 Selenocompound metabolism # MISCELLANEOUS METE_ECOLI Has an absolute requirement for a polyglutamylated folate as substrate. Its activity depends on phosphate anions and divalent cations. # Organism METE_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route) step 1/1. # PATRIC 32123159 VBIEscCol129921_3945 # PIR F65187 A42863 # PIRSF PIRSF000382 MeTrfase_B12_ind # Pfam PF01717 Meth_synt_2 # Pfam PF08267 Meth_synt_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName METE_ECOLI 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase # RefSeq NP_418273 NC_000913.3 # RefSeq WP_000153907 NZ_LN832404.1 # SIMILARITY Belongs to the vitamin-B12 independent methionine synthase family. {ECO 0000305}. # SUBUNIT METE_ECOLI Monomer. # TIGRFAMs TIGR01371 met_syn_B12ind # UniPathway UPA00051 UER00082 # eggNOG COG0620 LUCA # eggNOG ENOG4105DSS Bacteria BLAST swissprot:METE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:METE_ECOLI BioCyc ECOL316407:JW3805-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3805-MONOMER BioCyc EcoCyc:HOMOCYSMET-MONOMER http://biocyc.org/getid?id=EcoCyc:HOMOCYSMET-MONOMER BioCyc MetaCyc:HOMOCYSMET-MONOMER http://biocyc.org/getid?id=MetaCyc:HOMOCYSMET-MONOMER COG COG0620 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0620 DIP DIP-6847N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-6847N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1021/bi00141a013 http://dx.doi.org/10.1021/bi00141a013 DOI 10.1021/bi9615452 http://dx.doi.org/10.1021/bi9615452 DOI 10.1021/bi992062b http://dx.doi.org/10.1021/bi992062b DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.86.1.85 http://dx.doi.org/10.1073/pnas.86.1.85 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.1.14 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.14 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J04155 http://www.ebi.ac.uk/ena/data/view/J04155 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL M87625 http://www.ebi.ac.uk/ena/data/view/M87625 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.1.1.14 http://enzyme.expasy.org/EC/2.1.1.14 EchoBASE EB0579 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0579 EcoGene EG10584 http://www.ecogene.org/geneInfo.php?eg_id=EG10584 EnsemblBacteria AAC76832 http://www.ensemblgenomes.org/id/AAC76832 EnsemblBacteria AAC76832 http://www.ensemblgenomes.org/id/AAC76832 EnsemblBacteria BAE77472 http://www.ensemblgenomes.org/id/BAE77472 EnsemblBacteria BAE77472 http://www.ensemblgenomes.org/id/BAE77472 EnsemblBacteria BAE77472 http://www.ensemblgenomes.org/id/BAE77472 EnsemblBacteria b3829 http://www.ensemblgenomes.org/id/b3829 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005576 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003871 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0008276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008276 GO_function GO:0008705 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008705 GO_process GO:0009086 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009086 GO_process GO:0035999 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035999 GO_process GO:0050667 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050667 GOslim_component GO:0005576 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GeneID 948323 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948323 HAMAP MF_00172 http://hamap.expasy.org/unirule/MF_00172 HOGENOM HOG000246221 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000246221&db=HOGENOM6 InParanoid P25665 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P25665 IntAct P25665 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P25665* IntEnz 2.1.1.14 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.14 InterPro IPR002629 http://www.ebi.ac.uk/interpro/entry/IPR002629 InterPro IPR006276 http://www.ebi.ac.uk/interpro/entry/IPR006276 InterPro IPR013215 http://www.ebi.ac.uk/interpro/entry/IPR013215 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3805 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3805 KEGG_Gene eco:b3829 http://www.genome.jp/dbget-bin/www_bget?eco:b3829 KEGG_Orthology KO:K00549 http://www.genome.jp/dbget-bin/www_bget?KO:K00549 KEGG_Pathway ko00270 http://www.genome.jp/kegg-bin/show_pathway?ko00270 KEGG_Pathway ko00450 http://www.genome.jp/kegg-bin/show_pathway?ko00450 KEGG_Reaction rn:R04405 http://www.genome.jp/dbget-bin/www_bget?rn:R04405 KEGG_Reaction rn:R09365 http://www.genome.jp/dbget-bin/www_bget?rn:R09365 MINT MINT-1280694 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1280694 OMA RFGWVQS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RFGWVQS PSORT swissprot:METE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:METE_ECOLI PSORT-B swissprot:METE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:METE_ECOLI PSORT2 swissprot:METE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:METE_ECOLI Pfam PF01717 http://pfam.xfam.org/family/PF01717 Pfam PF08267 http://pfam.xfam.org/family/PF08267 Phobius swissprot:METE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:METE_ECOLI PhylomeDB P25665 http://phylomedb.org/?seqid=P25665 ProteinModelPortal P25665 http://www.proteinmodelportal.org/query/uniprot/P25665 PubMed 10625458 http://www.ncbi.nlm.nih.gov/pubmed/10625458 PubMed 1339288 http://www.ncbi.nlm.nih.gov/pubmed/1339288 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2643109 http://www.ncbi.nlm.nih.gov/pubmed/2643109 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 8823155 http://www.ncbi.nlm.nih.gov/pubmed/8823155 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_418273 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418273 RefSeq WP_000153907 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000153907 SMR P25665 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P25665 STRING 511145.b3829 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3829&targetmode=cogs STRING COG0620 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0620&targetmode=cogs TIGRFAMs TIGR01371 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01371 UniProtKB METE_ECOLI http://www.uniprot.org/uniprot/METE_ECOLI UniProtKB-AC P25665 http://www.uniprot.org/uniprot/P25665 charge swissprot:METE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:METE_ECOLI eggNOG COG0620 http://eggnogapi.embl.de/nog_data/html/tree/COG0620 eggNOG ENOG4105DSS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DSS epestfind swissprot:METE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:METE_ECOLI garnier swissprot:METE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:METE_ECOLI helixturnhelix swissprot:METE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:METE_ECOLI hmoment swissprot:METE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:METE_ECOLI iep swissprot:METE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:METE_ECOLI inforesidue swissprot:METE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:METE_ECOLI octanol swissprot:METE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:METE_ECOLI pepcoil swissprot:METE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:METE_ECOLI pepdigest swissprot:METE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:METE_ECOLI pepinfo swissprot:METE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:METE_ECOLI pepnet swissprot:METE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:METE_ECOLI pepstats swissprot:METE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:METE_ECOLI pepwheel swissprot:METE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:METE_ECOLI pepwindow swissprot:METE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:METE_ECOLI sigcleave swissprot:METE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:METE_ECOLI ## Database ID URL or Descriptions # BioGrid 4263004 190 # EcoGene EG13794 yddW # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IBA:GO_Central. # GO_process GO:0005975 carbohydrate metabolic process; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0005975 carbohydrate metabolic process # Gene3D 3.20.20.80 -; 1. # InterPro IPR003790 GHL10 # InterPro IPR013781 Glyco_hydro_catalytic_dom # InterPro IPR017853 Glycoside_hydrolase_SF # Organism YDDW_ECOLI Escherichia coli (strain K12) # PATRIC 32118276 VBIEscCol129921_1558 # PIR F64902 F64902 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF02638 GHL10 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDDW_ECOLI UPF0748 lipoprotein YddW # RefSeq NP_416008 NC_000913.3 # SIMILARITY Belongs to the UPF0748 family. {ECO 0000305}. # SUBCELLULAR LOCATION YDDW_ECOLI Cell membrane {ECO 0000255|PROSITE- ProRule PRU00303}; Lipid-anchor {ECO 0000255|PROSITE- ProRule PRU00303}. # SUPFAM SSF51445 SSF51445 # eggNOG COG1649 LUCA # eggNOG ENOG4105F32 Bacteria BLAST swissprot:YDDW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDDW_ECOLI BioCyc ECOL316407:JW1486-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1486-MONOMER BioCyc EcoCyc:G6785-MONOMER http://biocyc.org/getid?id=EcoCyc:G6785-MONOMER DIP DIP-48187N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48187N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3555 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3555 EcoGene EG13794 http://www.ecogene.org/geneInfo.php?eg_id=EG13794 EnsemblBacteria AAC74564 http://www.ensemblgenomes.org/id/AAC74564 EnsemblBacteria AAC74564 http://www.ensemblgenomes.org/id/AAC74564 EnsemblBacteria BAE76454 http://www.ensemblgenomes.org/id/BAE76454 EnsemblBacteria BAE76454 http://www.ensemblgenomes.org/id/BAE76454 EnsemblBacteria BAE76454 http://www.ensemblgenomes.org/id/BAE76454 EnsemblBacteria b1491 http://www.ensemblgenomes.org/id/b1491 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 Gene3D 3.20.20.80 http://www.cathdb.info/version/latest/superfamily/3.20.20.80 GeneID 945975 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945975 HOGENOM HOG000035282 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000035282&db=HOGENOM6 InParanoid P64426 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P64426 IntAct P64426 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P64426* InterPro IPR003790 http://www.ebi.ac.uk/interpro/entry/IPR003790 InterPro IPR013781 http://www.ebi.ac.uk/interpro/entry/IPR013781 InterPro IPR017853 http://www.ebi.ac.uk/interpro/entry/IPR017853 KEGG_Gene ecj:JW1486 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1486 KEGG_Gene eco:b1491 http://www.genome.jp/dbget-bin/www_bget?eco:b1491 OMA KPTHTRL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KPTHTRL PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YDDW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDDW_ECOLI PSORT-B swissprot:YDDW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDDW_ECOLI PSORT2 swissprot:YDDW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDDW_ECOLI Pfam PF02638 http://pfam.xfam.org/family/PF02638 Phobius swissprot:YDDW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDDW_ECOLI PhylomeDB P64426 http://phylomedb.org/?seqid=P64426 ProteinModelPortal P64426 http://www.proteinmodelportal.org/query/uniprot/P64426 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416008 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416008 STRING 511145.b1491 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1491&targetmode=cogs SUPFAM SSF51445 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51445 UniProtKB YDDW_ECOLI http://www.uniprot.org/uniprot/YDDW_ECOLI UniProtKB-AC P64426 http://www.uniprot.org/uniprot/P64426 charge swissprot:YDDW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDDW_ECOLI eggNOG COG1649 http://eggnogapi.embl.de/nog_data/html/tree/COG1649 eggNOG ENOG4105F32 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F32 epestfind swissprot:YDDW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDDW_ECOLI garnier swissprot:YDDW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDDW_ECOLI helixturnhelix swissprot:YDDW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDDW_ECOLI hmoment swissprot:YDDW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDDW_ECOLI iep swissprot:YDDW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDDW_ECOLI inforesidue swissprot:YDDW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDDW_ECOLI octanol swissprot:YDDW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDDW_ECOLI pepcoil swissprot:YDDW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDDW_ECOLI pepdigest swissprot:YDDW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDDW_ECOLI pepinfo swissprot:YDDW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDDW_ECOLI pepnet swissprot:YDDW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDDW_ECOLI pepstats swissprot:YDDW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDDW_ECOLI pepwheel swissprot:YDDW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDDW_ECOLI pepwindow swissprot:YDDW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDDW_ECOLI sigcleave swissprot:YDDW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDDW_ECOLI ## Database ID URL or Descriptions # BioGrid 4262912 12 # CAUTION Was originally thought to be the miniconductance mechanosensitive channel MscM. {ECO:0000305|PubMed 20616037}. # EcoGene EG12620 ybdG # FUNCTION YBDG_ECOLI Mechanosensitive channel of miniconductance that confers protection against mild hypoosmotic shock. Overexpression confers protection against severe shocks. {ECO 0000269|PubMed 20616037}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0008381 mechanically-gated ion channel activity; IMP:EcoCyc. # GO_process GO:0006970 response to osmotic stress; IGI:EcoliWiki. # GO_process GO:0071470 cellular response to osmotic stress; IEP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006950 response to stress # INDUCTION Induced by growth at high osmolarity. {ECO:0000269|PubMed 20616037}. # IntAct P0AAT4 4 # InterPro IPR006685 MscS_channel # InterPro IPR010920 LSM_dom # InterPro IPR011066 MscC_channel_C # InterPro IPR030192 YbdG # KEGG_Brite ko02000 Transporters # Organism YBDG_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30414:SF0 PTHR30414:SF0 # PATRIC 32116322 VBIEscCol129921_0601 # PIR G64790 G64790 # Pfam PF00924 MS_channel # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBDG_ECOLI Miniconductance mechanosensitive channel YbdG # RefSeq NP_415109 NC_000913.3 # RefSeq WP_001153148 NZ_LN832404.1 # SIMILARITY Belongs to the MscS (TC 1.A.23) family. {ECO 0000305}. # SUBCELLULAR LOCATION YBDG_ECOLI Cell inner membrane {ECO 0000269|PubMed 20616037}; Multi-pass membrane protein {ECO 0000269|PubMed 20616037}. # SUBUNIT Homoheptamer. {ECO:0000305|PubMed 20616037}. # SUPFAM SSF50182 SSF50182 # SUPFAM SSF82689 SSF82689 # TCDB 1.A.23.4 the small conductance mechanosensitive ion channel (mscs) family # eggNOG COG0668 LUCA # eggNOG ENOG4105CUY Bacteria BLAST swissprot:YBDG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBDG_ECOLI BioCyc ECOL316407:JW0566-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0566-MONOMER BioCyc EcoCyc:G6323-MONOMER http://biocyc.org/getid?id=EcoCyc:G6323-MONOMER COG COG0668 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0668 DIP DIP-51225N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-51225N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.1001405107 http://dx.doi.org/10.1073/pnas.1001405107 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1574-6968.1994.tb07284.x http://dx.doi.org/10.1111/j.1574-6968.1994.tb07284.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.4161/chan.20998 http://dx.doi.org/10.4161/chan.20998 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D25414 http://www.ebi.ac.uk/ena/data/view/D25414 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U07860 http://www.ebi.ac.uk/ena/data/view/U07860 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB2504 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2504 EcoGene EG12620 http://www.ecogene.org/geneInfo.php?eg_id=EG12620 EnsemblBacteria AAC73678 http://www.ensemblgenomes.org/id/AAC73678 EnsemblBacteria AAC73678 http://www.ensemblgenomes.org/id/AAC73678 EnsemblBacteria BAA35217 http://www.ensemblgenomes.org/id/BAA35217 EnsemblBacteria BAA35217 http://www.ensemblgenomes.org/id/BAA35217 EnsemblBacteria BAA35217 http://www.ensemblgenomes.org/id/BAA35217 EnsemblBacteria b0577 http://www.ensemblgenomes.org/id/b0577 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008381 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008381 GO_process GO:0006970 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006970 GO_process GO:0071470 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071470 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 946243 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946243 HOGENOM HOG000199955 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000199955&db=HOGENOM6 InParanoid P0AAT4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAT4 IntAct P0AAT4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAT4* InterPro IPR006685 http://www.ebi.ac.uk/interpro/entry/IPR006685 InterPro IPR010920 http://www.ebi.ac.uk/interpro/entry/IPR010920 InterPro IPR011066 http://www.ebi.ac.uk/interpro/entry/IPR011066 InterPro IPR030192 http://www.ebi.ac.uk/interpro/entry/IPR030192 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0566 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0566 KEGG_Gene eco:b0577 http://www.genome.jp/dbget-bin/www_bget?eco:b0577 KEGG_Orthology KO:K16053 http://www.genome.jp/dbget-bin/www_bget?KO:K16053 OMA IHFLDEQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IHFLDEQ PANTHER PTHR30414:SF0 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30414:SF0 PSORT swissprot:YBDG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBDG_ECOLI PSORT-B swissprot:YBDG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBDG_ECOLI PSORT2 swissprot:YBDG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBDG_ECOLI Pfam PF00924 http://pfam.xfam.org/family/PF00924 Phobius swissprot:YBDG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBDG_ECOLI PhylomeDB P0AAT4 http://phylomedb.org/?seqid=P0AAT4 ProteinModelPortal P0AAT4 http://www.proteinmodelportal.org/query/uniprot/P0AAT4 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20616037 http://www.ncbi.nlm.nih.gov/pubmed/20616037 PubMed 22874652 http://www.ncbi.nlm.nih.gov/pubmed/22874652 PubMed 7813889 http://www.ncbi.nlm.nih.gov/pubmed/7813889 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415109 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415109 RefSeq WP_001153148 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001153148 STRING 511145.b0577 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0577&targetmode=cogs STRING COG0668 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0668&targetmode=cogs SUPFAM SSF50182 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50182 SUPFAM SSF82689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF82689 TCDB 1.A.23.4 http://www.tcdb.org/search/result.php?tc=1.A.23.4 UniProtKB YBDG_ECOLI http://www.uniprot.org/uniprot/YBDG_ECOLI UniProtKB-AC P0AAT4 http://www.uniprot.org/uniprot/P0AAT4 charge swissprot:YBDG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBDG_ECOLI eggNOG COG0668 http://eggnogapi.embl.de/nog_data/html/tree/COG0668 eggNOG ENOG4105CUY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CUY epestfind swissprot:YBDG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBDG_ECOLI garnier swissprot:YBDG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBDG_ECOLI helixturnhelix swissprot:YBDG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBDG_ECOLI hmoment swissprot:YBDG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBDG_ECOLI iep swissprot:YBDG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBDG_ECOLI inforesidue swissprot:YBDG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBDG_ECOLI octanol swissprot:YBDG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBDG_ECOLI pepcoil swissprot:YBDG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBDG_ECOLI pepdigest swissprot:YBDG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBDG_ECOLI pepinfo swissprot:YBDG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBDG_ECOLI pepnet swissprot:YBDG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBDG_ECOLI pepstats swissprot:YBDG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBDG_ECOLI pepwheel swissprot:YBDG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBDG_ECOLI pepwindow swissprot:YBDG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBDG_ECOLI sigcleave swissprot:YBDG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBDG_ECOLI ## Database ID URL or Descriptions # BioGrid 4260895 10 # EcoGene EG14147 yfdY # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR024470 DUF2545 # Organism YFDY_ECOLI Escherichia coli (strain K12) # PATRIC 32120131 VBIEscCol129921_2474 # PIR F65011 F65011 # Pfam PF10810 DUF2545 # ProDom PD857460 PD857460 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFDY_ECOLI Uncharacterized protein YfdY # RefSeq NP_416878 NC_000913.3 # RefSeq WP_000609275 NZ_LN832404.1 # SUBCELLULAR LOCATION YFDY_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # eggNOG ENOG4105W9M Bacteria # eggNOG ENOG4112AZ4 LUCA BLAST swissprot:YFDY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFDY_ECOLI BioCyc ECOL316407:JW2374-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2374-MONOMER BioCyc EcoCyc:G7240-MONOMER http://biocyc.org/getid?id=EcoCyc:G7240-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3899 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3899 EcoGene EG14147 http://www.ecogene.org/geneInfo.php?eg_id=EG14147 EnsemblBacteria AAC75436 http://www.ensemblgenomes.org/id/AAC75436 EnsemblBacteria AAC75436 http://www.ensemblgenomes.org/id/AAC75436 EnsemblBacteria BAE76707 http://www.ensemblgenomes.org/id/BAE76707 EnsemblBacteria BAE76707 http://www.ensemblgenomes.org/id/BAE76707 EnsemblBacteria BAE76707 http://www.ensemblgenomes.org/id/BAE76707 EnsemblBacteria b2377 http://www.ensemblgenomes.org/id/b2377 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 948842 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948842 HOGENOM HOG000009522 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009522&db=HOGENOM6 InterPro IPR024470 http://www.ebi.ac.uk/interpro/entry/IPR024470 KEGG_Gene ecj:JW2374 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2374 KEGG_Gene eco:b2377 http://www.genome.jp/dbget-bin/www_bget?eco:b2377 OMA VSCYIGQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VSCYIGQ PSORT swissprot:YFDY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFDY_ECOLI PSORT-B swissprot:YFDY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFDY_ECOLI PSORT2 swissprot:YFDY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFDY_ECOLI Pfam PF10810 http://pfam.xfam.org/family/PF10810 Phobius swissprot:YFDY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFDY_ECOLI ProteinModelPortal P76521 http://www.proteinmodelportal.org/query/uniprot/P76521 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416878 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416878 RefSeq WP_000609275 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000609275 UniProtKB YFDY_ECOLI http://www.uniprot.org/uniprot/YFDY_ECOLI UniProtKB-AC P76521 http://www.uniprot.org/uniprot/P76521 charge swissprot:YFDY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFDY_ECOLI eggNOG ENOG4105W9M http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105W9M eggNOG ENOG4112AZ4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4112AZ4 epestfind swissprot:YFDY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFDY_ECOLI garnier swissprot:YFDY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFDY_ECOLI helixturnhelix swissprot:YFDY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFDY_ECOLI hmoment swissprot:YFDY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFDY_ECOLI iep swissprot:YFDY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFDY_ECOLI inforesidue swissprot:YFDY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFDY_ECOLI octanol swissprot:YFDY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFDY_ECOLI pepcoil swissprot:YFDY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFDY_ECOLI pepdigest swissprot:YFDY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFDY_ECOLI pepinfo swissprot:YFDY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFDY_ECOLI pepnet swissprot:YFDY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFDY_ECOLI pepstats swissprot:YFDY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFDY_ECOLI pepwheel swissprot:YFDY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFDY_ECOLI pepwindow swissprot:YFDY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFDY_ECOLI sigcleave swissprot:YFDY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFDY_ECOLI ## Database ID URL or Descriptions # AltName LYXK_ECOLI 3-dehydro-L-gulonate kinase # BIOPHYSICOCHEMICAL PROPERTIES LYXK_ECOLI Kinetic parameters KM=0.8 mM for L-xylulose {ECO 0000269|PubMed 7961955}; KM=0.4 mM for ATP {ECO 0000269|PubMed 7961955}; Vmax=33 umol/min/mg enzyme with L-xylulose as substrate {ECO 0000269|PubMed 7961955}; pH dependence Optimum pH is 8.4 with L-xylulose as substrate. {ECO 0000269|PubMed 7961955}; # BioGrid 4262550 7 # CATALYTIC ACTIVITY LYXK_ECOLI ATP + 3-dehydro-L-gulonate = ADP + 3-dehydro- L-gulonate 6-phosphate. # CATALYTIC ACTIVITY LYXK_ECOLI ATP + L-xylulose = ADP + L-xylulose 5- phosphate. # EcoGene EG12284 lyx # FUNCTION LYXK_ECOLI Catalyzes the phosphorylation of L-xylulose and 3-keto- L-gulonate. Is involved in L-lyxose utilization via xylulose, and may also be involved in the utilization of 2,3-diketo-L-gulonate. {ECO 0000269|PubMed 11741871, ECO 0000269|PubMed 7961955}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0008744 L-xylulokinase activity; IDA:EcoCyc. # GO_process GO:0019324 L-lyxose metabolic process; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0044281 small molecule metabolic process # IntAct P37677 2 # InterPro IPR000577 Carb_kinase_FGGY # InterPro IPR018483 Carb_kinase_FGGY_CS # InterPro IPR018484 Carb_kinase_FGGY_N # InterPro IPR018485 Carb_kinase_FGGY_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00040 Pentose and glucuronate interconversions # KEGG_Pathway ko00053 Ascorbate and aldarate metabolism # Organism LYXK_ECOLI Escherichia coli (strain K12) # PATRIC 32122636 VBIEscCol129921_3695 # PIR S47801 S47801 # PIRSF PIRSF000538 GlpK # PROSITE PS00445 FGGY_KINASES_2 # Pfam PF00370 FGGY_N # Pfam PF02782 FGGY_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LYXK_ECOLI L-xylulose/3-keto-L-gulonate kinase # RefSeq NP_418037 NC_000913.3 # RefSeq WP_000196054 NZ_LN832404.1 # SIMILARITY Belongs to the FGGY kinase family. {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 7961955}. # eggNOG COG1070 LUCA # eggNOG ENOG4105CMG Bacteria BLAST swissprot:LYXK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LYXK_ECOLI BioCyc ECOL316407:JW3552-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3552-MONOMER BioCyc EcoCyc:LYXK-MONOMER http://biocyc.org/getid?id=EcoCyc:LYXK-MONOMER BioCyc MetaCyc:LYXK-MONOMER http://biocyc.org/getid?id=MetaCyc:LYXK-MONOMER COG COG1070 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1070 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.1.302-306.2002 http://dx.doi.org/10.1128/JB.184.1.302-306.2002 EC_number EC:2.7.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.- EC_number EC:2.7.1.53 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.53 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.- http://enzyme.expasy.org/EC/2.7.1.- ENZYME 2.7.1.53 http://enzyme.expasy.org/EC/2.7.1.53 EchoBASE EB2192 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2192 EcoGene EG12284 http://www.ecogene.org/geneInfo.php?eg_id=EG12284 EnsemblBacteria AAC76604 http://www.ensemblgenomes.org/id/AAC76604 EnsemblBacteria AAC76604 http://www.ensemblgenomes.org/id/AAC76604 EnsemblBacteria BAE77713 http://www.ensemblgenomes.org/id/BAE77713 EnsemblBacteria BAE77713 http://www.ensemblgenomes.org/id/BAE77713 EnsemblBacteria BAE77713 http://www.ensemblgenomes.org/id/BAE77713 EnsemblBacteria b3580 http://www.ensemblgenomes.org/id/b3580 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008744 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008744 GO_process GO:0019324 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019324 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 948101 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948101 HOGENOM HOG000222135 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000222135&db=HOGENOM6 InParanoid P37677 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37677 IntAct P37677 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37677* IntEnz 2.7.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1 IntEnz 2.7.1.53 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.53 InterPro IPR000577 http://www.ebi.ac.uk/interpro/entry/IPR000577 InterPro IPR018483 http://www.ebi.ac.uk/interpro/entry/IPR018483 InterPro IPR018484 http://www.ebi.ac.uk/interpro/entry/IPR018484 InterPro IPR018485 http://www.ebi.ac.uk/interpro/entry/IPR018485 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3552 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3552 KEGG_Gene eco:b3580 http://www.genome.jp/dbget-bin/www_bget?eco:b3580 KEGG_Orthology KO:K00880 http://www.genome.jp/dbget-bin/www_bget?KO:K00880 KEGG_Pathway ko00040 http://www.genome.jp/kegg-bin/show_pathway?ko00040 KEGG_Pathway ko00053 http://www.genome.jp/kegg-bin/show_pathway?ko00053 KEGG_Reaction rn:R01901 http://www.genome.jp/dbget-bin/www_bget?rn:R01901 KEGG_Reaction rn:R07127 http://www.genome.jp/dbget-bin/www_bget?rn:R07127 OMA ACEETNI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ACEETNI PROSITE PS00445 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00445 PSORT swissprot:LYXK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LYXK_ECOLI PSORT-B swissprot:LYXK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LYXK_ECOLI PSORT2 swissprot:LYXK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LYXK_ECOLI Pfam PF00370 http://pfam.xfam.org/family/PF00370 Pfam PF02782 http://pfam.xfam.org/family/PF02782 Phobius swissprot:LYXK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LYXK_ECOLI PhylomeDB P37677 http://phylomedb.org/?seqid=P37677 ProteinModelPortal P37677 http://www.proteinmodelportal.org/query/uniprot/P37677 PubMed 11741871 http://www.ncbi.nlm.nih.gov/pubmed/11741871 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7961955 http://www.ncbi.nlm.nih.gov/pubmed/7961955 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418037 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418037 RefSeq WP_000196054 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000196054 SMR P37677 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37677 STRING 511145.b3580 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3580&targetmode=cogs STRING COG1070 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1070&targetmode=cogs UniProtKB LYXK_ECOLI http://www.uniprot.org/uniprot/LYXK_ECOLI UniProtKB-AC P37677 http://www.uniprot.org/uniprot/P37677 charge swissprot:LYXK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LYXK_ECOLI eggNOG COG1070 http://eggnogapi.embl.de/nog_data/html/tree/COG1070 eggNOG ENOG4105CMG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CMG epestfind swissprot:LYXK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LYXK_ECOLI garnier swissprot:LYXK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LYXK_ECOLI helixturnhelix swissprot:LYXK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LYXK_ECOLI hmoment swissprot:LYXK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LYXK_ECOLI iep swissprot:LYXK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LYXK_ECOLI inforesidue swissprot:LYXK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LYXK_ECOLI octanol swissprot:LYXK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LYXK_ECOLI pepcoil swissprot:LYXK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LYXK_ECOLI pepdigest swissprot:LYXK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LYXK_ECOLI pepinfo swissprot:LYXK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LYXK_ECOLI pepnet swissprot:LYXK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LYXK_ECOLI pepstats swissprot:LYXK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LYXK_ECOLI pepwheel swissprot:LYXK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LYXK_ECOLI pepwindow swissprot:LYXK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LYXK_ECOLI sigcleave swissprot:LYXK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LYXK_ECOLI ## Database ID URL or Descriptions # BioGrid 4260796 7 # EcoGene EG12825 aaeR # FUNCTION AAER_ECOLI Activates transcription of the aaeXAB operon. {ECO 0000269|PubMed 15489430}. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IMP:EcoCyc. # GO_process GO:0006352 DNA-templated transcription, initiation; IMP:EcoliWiki. # GO_process GO:0006355 regulation of transcription, DNA-templated; IMP:EcoliWiki. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IMP:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # IntAct P67662 3 # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR005119 LysR_subst-bd # InterPro IPR011991 WHTH_DNA-bd_dom # Organism AAER_ECOLI Escherichia coli (strain K12) # PATRIC 32121912 VBIEscCol129921_3340 # PIR E65116 E65116 # PROSITE PS50931 HTH_LYSR # Pfam PF00126 HTH_1 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AAER_ECOLI HTH-type transcriptional activator AaeR # RefSeq NP_417710 NC_000913.3 # RefSeq WP_000440317 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lysR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00253}. # SUPFAM SSF46785 SSF46785 # eggNOG ENOG4105CR8 Bacteria # eggNOG ENOG410XNYU LUCA BLAST swissprot:AAER_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AAER_ECOLI BioCyc ECOL316407:JW3212-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3212-MONOMER BioCyc EcoCyc:G7688-MONOMER http://biocyc.org/getid?id=EcoCyc:G7688-MONOMER DIP DIP-12291N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12291N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.186.21.7196-7204.2004 http://dx.doi.org/10.1128/JB.186.21.7196-7204.2004 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2676 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2676 EcoGene EG12825 http://www.ecogene.org/geneInfo.php?eg_id=EG12825 EnsemblBacteria AAC76275 http://www.ensemblgenomes.org/id/AAC76275 EnsemblBacteria AAC76275 http://www.ensemblgenomes.org/id/AAC76275 EnsemblBacteria BAE77286 http://www.ensemblgenomes.org/id/BAE77286 EnsemblBacteria BAE77286 http://www.ensemblgenomes.org/id/BAE77286 EnsemblBacteria BAE77286 http://www.ensemblgenomes.org/id/BAE77286 EnsemblBacteria b3243 http://www.ensemblgenomes.org/id/b3243 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006352 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006352 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 947760 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947760 HOGENOM HOG000233519 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000233519&db=HOGENOM6 InParanoid P67662 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P67662 IntAct P67662 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P67662* InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW3212 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3212 KEGG_Gene eco:b3243 http://www.genome.jp/dbget-bin/www_bget?eco:b3243 OMA KSYLAQY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KSYLAQY PROSITE PS50931 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50931 PSORT swissprot:AAER_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AAER_ECOLI PSORT-B swissprot:AAER_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AAER_ECOLI PSORT2 swissprot:AAER_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AAER_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:AAER_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AAER_ECOLI PhylomeDB P67662 http://phylomedb.org/?seqid=P67662 ProteinModelPortal P67662 http://www.proteinmodelportal.org/query/uniprot/P67662 PubMed 15489430 http://www.ncbi.nlm.nih.gov/pubmed/15489430 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417710 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417710 RefSeq WP_000440317 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000440317 SMR P67662 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P67662 STRING 511145.b3243 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3243&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB AAER_ECOLI http://www.uniprot.org/uniprot/AAER_ECOLI UniProtKB-AC P67662 http://www.uniprot.org/uniprot/P67662 charge swissprot:AAER_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AAER_ECOLI eggNOG ENOG4105CR8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CR8 eggNOG ENOG410XNYU http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNYU epestfind swissprot:AAER_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AAER_ECOLI garnier swissprot:AAER_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AAER_ECOLI helixturnhelix swissprot:AAER_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AAER_ECOLI hmoment swissprot:AAER_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AAER_ECOLI iep swissprot:AAER_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AAER_ECOLI inforesidue swissprot:AAER_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AAER_ECOLI octanol swissprot:AAER_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AAER_ECOLI pepcoil swissprot:AAER_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AAER_ECOLI pepdigest swissprot:AAER_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AAER_ECOLI pepinfo swissprot:AAER_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AAER_ECOLI pepnet swissprot:AAER_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AAER_ECOLI pepstats swissprot:AAER_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AAER_ECOLI pepwheel swissprot:AAER_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AAER_ECOLI pepwindow swissprot:AAER_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AAER_ECOLI sigcleave swissprot:AAER_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AAER_ECOLI ## Database ID URL or Descriptions # BioGrid 4259659 5 # EcoGene EG14314 yqjK # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # IntAct Q47710 3 # InterPro IPR025612 YqjK # Organism YQJK_ECOLI Escherichia coli (strain K12) # PATRIC 32121620 VBIEscCol129921_3196 # PIR A65099 A65099 # Pfam PF13997 YqjK # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQJK_ECOLI Uncharacterized protein YqjK # RefSeq NP_417571 NC_000913.3 # RefSeq WP_000096091 NZ_LN832404.1 # eggNOG ENOG4105YJD Bacteria # eggNOG ENOG41122JM LUCA BLAST swissprot:YQJK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQJK_ECOLI BioCyc ECOL316407:JW3071-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3071-MONOMER BioCyc EcoCyc:G7614-MONOMER http://biocyc.org/getid?id=EcoCyc:G7614-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB4061 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4061 EcoGene EG14314 http://www.ecogene.org/geneInfo.php?eg_id=EG14314 EnsemblBacteria AAC76135 http://www.ensemblgenomes.org/id/AAC76135 EnsemblBacteria AAC76135 http://www.ensemblgenomes.org/id/AAC76135 EnsemblBacteria BAE77150 http://www.ensemblgenomes.org/id/BAE77150 EnsemblBacteria BAE77150 http://www.ensemblgenomes.org/id/BAE77150 EnsemblBacteria BAE77150 http://www.ensemblgenomes.org/id/BAE77150 EnsemblBacteria b3100 http://www.ensemblgenomes.org/id/b3100 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GeneID 947610 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947610 HOGENOM HOG000125159 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125159&db=HOGENOM6 IntAct Q47710 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q47710* InterPro IPR025612 http://www.ebi.ac.uk/interpro/entry/IPR025612 KEGG_Gene ecj:JW3071 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3071 KEGG_Gene eco:b3100 http://www.genome.jp/dbget-bin/www_bget?eco:b3100 OMA RWAKRGF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RWAKRGF PSORT swissprot:YQJK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQJK_ECOLI PSORT-B swissprot:YQJK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQJK_ECOLI PSORT2 swissprot:YQJK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQJK_ECOLI Pfam PF13997 http://pfam.xfam.org/family/PF13997 Phobius swissprot:YQJK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQJK_ECOLI ProteinModelPortal Q47710 http://www.proteinmodelportal.org/query/uniprot/Q47710 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417571 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417571 RefSeq WP_000096091 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000096091 STRING 511145.b3100 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3100&targetmode=cogs UniProtKB YQJK_ECOLI http://www.uniprot.org/uniprot/YQJK_ECOLI UniProtKB-AC Q47710 http://www.uniprot.org/uniprot/Q47710 charge swissprot:YQJK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQJK_ECOLI eggNOG ENOG4105YJD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105YJD eggNOG ENOG41122JM http://eggnogapi.embl.de/nog_data/html/tree/ENOG41122JM epestfind swissprot:YQJK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQJK_ECOLI garnier swissprot:YQJK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQJK_ECOLI helixturnhelix swissprot:YQJK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQJK_ECOLI hmoment swissprot:YQJK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQJK_ECOLI iep swissprot:YQJK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQJK_ECOLI inforesidue swissprot:YQJK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQJK_ECOLI octanol swissprot:YQJK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQJK_ECOLI pepcoil swissprot:YQJK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQJK_ECOLI pepdigest swissprot:YQJK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQJK_ECOLI pepinfo swissprot:YQJK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQJK_ECOLI pepnet swissprot:YQJK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQJK_ECOLI pepstats swissprot:YQJK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQJK_ECOLI pepwheel swissprot:YQJK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQJK_ECOLI pepwindow swissprot:YQJK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQJK_ECOLI sigcleave swissprot:YQJK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQJK_ECOLI ## Database ID URL or Descriptions # BioGrid 4261835 7 # EcoGene EG13675 ybhS # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0015562 efflux transmembrane transporter activity; IBA:GO_Central. # GO_process GO:0055085 transmembrane transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0055085 transmembrane transport # IntAct P0AFQ2 5 # InterPro IPR000412 ABC_2_transport # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00254 ABC-2 type transport system # KEGG_Brite ko02000 Transporters # Organism YBHS_ECOLI Escherichia coli (strain K12) # PATRIC 32116787 VBIEscCol129921_0819 # PIR A64816 A64816 # PROSITE PS51012 ABC_TM2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBHS_ECOLI Inner membrane transport permease YbhS # RefSeq NP_415314 NC_000913.3 # RefSeq WP_000070131 NZ_LN832404.1 # SIMILARITY Belongs to the ABC-2 integral membrane protein family. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-2 domain. {ECO:0000255|PROSITE-ProRule PRU00442}. # SUBCELLULAR LOCATION YBHS_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG COG0842 LUCA # eggNOG ENOG4107QWP Bacteria BLAST swissprot:YBHS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBHS_ECOLI BioCyc ECOL316407:JW0777-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0777-MONOMER BioCyc EcoCyc:YBHS-MONOMER http://biocyc.org/getid?id=EcoCyc:YBHS-MONOMER COG COG0842 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0842 COG COG1277 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1277 COG COG1682 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1682 COG COG3694 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3694 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3439 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3439 EcoGene EG13675 http://www.ecogene.org/geneInfo.php?eg_id=EG13675 EnsemblBacteria AAC73880 http://www.ensemblgenomes.org/id/AAC73880 EnsemblBacteria AAC73880 http://www.ensemblgenomes.org/id/AAC73880 EnsemblBacteria BAA35453 http://www.ensemblgenomes.org/id/BAA35453 EnsemblBacteria BAA35453 http://www.ensemblgenomes.org/id/BAA35453 EnsemblBacteria BAA35453 http://www.ensemblgenomes.org/id/BAA35453 EnsemblBacteria b0793 http://www.ensemblgenomes.org/id/b0793 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015562 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015562 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 945411 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945411 HOGENOM HOG000270977 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000270977&db=HOGENOM6 InParanoid P0AFQ2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFQ2 IntAct P0AFQ2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFQ2* InterPro IPR000412 http://www.ebi.ac.uk/interpro/entry/IPR000412 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0777 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0777 KEGG_Gene eco:b0793 http://www.genome.jp/dbget-bin/www_bget?eco:b0793 KEGG_Orthology KO:K01992 http://www.genome.jp/dbget-bin/www_bget?KO:K01992 OMA PYRGSLW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PYRGSLW PROSITE PS51012 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51012 PSORT swissprot:YBHS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBHS_ECOLI PSORT-B swissprot:YBHS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBHS_ECOLI PSORT2 swissprot:YBHS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBHS_ECOLI Phobius swissprot:YBHS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBHS_ECOLI PhylomeDB P0AFQ2 http://phylomedb.org/?seqid=P0AFQ2 ProteinModelPortal P0AFQ2 http://www.proteinmodelportal.org/query/uniprot/P0AFQ2 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415314 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415314 RefSeq WP_000070131 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000070131 STRING 511145.b0793 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0793&targetmode=cogs STRING COG0842 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0842&targetmode=cogs STRING COG1277 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1277&targetmode=cogs STRING COG1682 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1682&targetmode=cogs STRING COG3694 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3694&targetmode=cogs UniProtKB YBHS_ECOLI http://www.uniprot.org/uniprot/YBHS_ECOLI UniProtKB-AC P0AFQ2 http://www.uniprot.org/uniprot/P0AFQ2 charge swissprot:YBHS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBHS_ECOLI eggNOG COG0842 http://eggnogapi.embl.de/nog_data/html/tree/COG0842 eggNOG ENOG4107QWP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QWP epestfind swissprot:YBHS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBHS_ECOLI garnier swissprot:YBHS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBHS_ECOLI helixturnhelix swissprot:YBHS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBHS_ECOLI hmoment swissprot:YBHS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBHS_ECOLI iep swissprot:YBHS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBHS_ECOLI inforesidue swissprot:YBHS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBHS_ECOLI octanol swissprot:YBHS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBHS_ECOLI pepcoil swissprot:YBHS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBHS_ECOLI pepdigest swissprot:YBHS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBHS_ECOLI pepinfo swissprot:YBHS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBHS_ECOLI pepnet swissprot:YBHS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBHS_ECOLI pepstats swissprot:YBHS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBHS_ECOLI pepwheel swissprot:YBHS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBHS_ECOLI pepwindow swissprot:YBHS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBHS_ECOLI sigcleave swissprot:YBHS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBHS_ECOLI ## Database ID URL or Descriptions # AltName GLPX_ECOLI D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 class 2 # BIOPHYSICOCHEMICAL PROPERTIES GLPX_ECOLI Kinetic parameters KM=35 uM for fructose 1,6-bisphosphate (at pH 7.7 and room temperature) {ECO 0000269|PubMed 10986273, ECO 0000269|PubMed 19073594}; KM=70 uM for fructose 1,6-bisphosphate (at pH 9.0 and 37 degrees Celsius) {ECO 0000269|PubMed 10986273, ECO 0000269|PubMed 19073594}; KM=0.6 mM for Mn(2+) (at pH 9.0 and 37 degrees Celsius) {ECO 0000269|PubMed 10986273, ECO 0000269|PubMed 19073594}; Vmax=3.3 umol/min/mg enzyme (at pH 7.7 and room temperature) {ECO 0000269|PubMed 10986273, ECO 0000269|PubMed 19073594}; Vmax=8.8 umol/min/mg enzyme (at pH 9.0 and 37 degrees Celsius) {ECO 0000269|PubMed 10986273, ECO 0000269|PubMed 19073594}; Note=The catalytic efficiency of GlpX is 3-fold higher than that of YggF, the other FBPase class 2 in E.coli.; pH dependence Optimum pH is 7.5-8. {ECO 0000269|PubMed 19073594}; # BRENDA 3.1.3.11 2026 # BioGrid 4260756 11 # CATALYTIC ACTIVITY GLPX_ECOLI D-fructose 1,6-bisphosphate + H(2)O = D- fructose 6-phosphate + phosphate. {ECO 0000269|PubMed 10986273, ECO 0000269|PubMed 19073594}. # CDD cd01516 FBPase_glpX # COFACTOR GLPX_ECOLI Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 10986273, ECO 0000269|PubMed 19073594}; Note=Manganese. Mg(2+), Co(2+), Ni(2+), Ca(2+), Cu(2+) and Zn(2+) cannot support activity. {ECO 0000269|PubMed 10986273, ECO 0000269|PubMed 19073594}; # DISRUPTION PHENOTYPE Cells lacking this gene grow normally on gluconeogenic substrates (succinate or glycerol). {ECO:0000269|PubMed 10986273}. # ENZYME REGULATION Competitively inhibited by low concentrations of phosphate (IC50 3.0 mM) and is also sensitive to Li(+) (IC50 70 mM). Slightly activated by KCl. {ECO:0000269|PubMed 19073594}. # EcoGene EG11517 glpX # FUNCTION GLPX_ECOLI Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate. Is likely to be involved in gluconeogenesis during growth on glycerol. Also displays a low activity toward glucose 1,6-bisphosphate, and no activity against ribulose 1,5- bisphosphate, fructose 2,6-bisphosphate, or fructose 1-phosphate. {ECO 0000269|PubMed 10986273, ECO 0000269|PubMed 19073594}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0030145 manganese ion binding; IDA:EcoCyc. # GO_function GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity; IDA:EcoCyc. # GO_process GO:0006071 glycerol metabolic process; IEA:InterPro. # GO_process GO:0006094 gluconeogenesis; IBA:GO_Central. # GO_process GO:0030388 fructose 1,6-bisphosphate metabolic process; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # INDUCTION By glycerol and sn-glycerol-3-phosphate. {ECO:0000269|PubMed 1400248}. # IntAct P0A9C9 6 # InterPro IPR004464 FBPase_class-2/SBPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00010 Glycolysis / Gluconeogenesis # KEGG_Pathway ko00030 Pentose phosphate pathway # KEGG_Pathway ko00051 Fructose and mannose metabolism # KEGG_Pathway ko00680 Methane metabolism # KEGG_Pathway ko00710 Carbon fixation in photosynthetic organisms # MISCELLANEOUS GLPX_ECOLI E.coli K12 also possesses a FBPase class 1 (Fbp), which is the primary FBPase in E.coli and probably represents the main gluconeogenic FBPase. # Organism GLPX_ECOLI Escherichia coli (strain K12) # PATHWAY GLPX_ECOLI Carbohydrate biosynthesis; gluconeogenesis. # PATRIC 32123363 VBIEscCol129921_4042 # PDB 1NI9 X-ray; 2.00 A; A=1-336 # PDB 2R8T X-ray; 2.30 A; A=1-336 # PDB 3BIG X-ray; 1.85 A; A=1-336 # PDB 3BIH X-ray; 2.10 A; A=1-336 # PDB 3D1R X-ray; 1.85 A; A=1-336 # PIR A45248 A45248 # PIRSF PIRSF004532 GlpX # Pfam PF03320 FBPase_glpX # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLPX_ECOLI Fructose-1,6-bisphosphatase 1 class 2 # RefSeq NP_418360 NC_000913.3 # RefSeq WP_001250644 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=M19644; Type=Miscellaneous discrepancy; Note=The C-terminal part of glpX was incorrectly assigned as being part of mvrA.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the FBPase class 2 family. {ECO 0000305}. # SUBCELLULAR LOCATION GLPX_ECOLI Cytoplasm. # SUBUNIT GLPX_ECOLI Homodimer. {ECO 0000269|PubMed 10986273, ECO 0000269|PubMed 19073594}. # TIGRFAMs TIGR00330 glpX # eggNOG COG1494 LUCA # eggNOG ENOG4105CBT Bacteria BLAST swissprot:GLPX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLPX_ECOLI BioCyc ECOL316407:JW3896-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3896-MONOMER BioCyc EcoCyc:EG11517-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11517-MONOMER BioCyc MetaCyc:EG11517-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11517-MONOMER COG COG1494 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1494 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M808186200 http://dx.doi.org/10.1074/jbc.M808186200 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.19.5624-5627.2000 http://dx.doi.org/10.1128/JB.182.19.5624-5627.2000 EC_number EC:3.1.3.11 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.11 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL M19644 http://www.ebi.ac.uk/ena/data/view/M19644 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL Z11767 http://www.ebi.ac.uk/ena/data/view/Z11767 ENZYME 3.1.3.11 http://enzyme.expasy.org/EC/3.1.3.11 EchoBASE EB1479 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1479 EcoGene EG11517 http://www.ecogene.org/geneInfo.php?eg_id=EG11517 EnsemblBacteria AAC76907 http://www.ensemblgenomes.org/id/AAC76907 EnsemblBacteria AAC76907 http://www.ensemblgenomes.org/id/AAC76907 EnsemblBacteria BAE77385 http://www.ensemblgenomes.org/id/BAE77385 EnsemblBacteria BAE77385 http://www.ensemblgenomes.org/id/BAE77385 EnsemblBacteria BAE77385 http://www.ensemblgenomes.org/id/BAE77385 EnsemblBacteria b3925 http://www.ensemblgenomes.org/id/b3925 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_function GO:0042132 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042132 GO_process GO:0006071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006071 GO_process GO:0006094 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006094 GO_process GO:0030388 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030388 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 948424 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948424 HOGENOM HOG000241252 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000241252&db=HOGENOM6 InParanoid P0A9C9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9C9 IntAct P0A9C9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9C9* IntEnz 3.1.3.11 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.11 InterPro IPR004464 http://www.ebi.ac.uk/interpro/entry/IPR004464 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3896 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3896 KEGG_Gene eco:b3925 http://www.genome.jp/dbget-bin/www_bget?eco:b3925 KEGG_Orthology KO:K02446 http://www.genome.jp/dbget-bin/www_bget?KO:K02446 KEGG_Pathway ko00010 http://www.genome.jp/kegg-bin/show_pathway?ko00010 KEGG_Pathway ko00030 http://www.genome.jp/kegg-bin/show_pathway?ko00030 KEGG_Pathway ko00051 http://www.genome.jp/kegg-bin/show_pathway?ko00051 KEGG_Pathway ko00680 http://www.genome.jp/kegg-bin/show_pathway?ko00680 KEGG_Pathway ko00710 http://www.genome.jp/kegg-bin/show_pathway?ko00710 KEGG_Reaction rn:R00762 http://www.genome.jp/dbget-bin/www_bget?rn:R00762 KEGG_Reaction rn:R04780 http://www.genome.jp/dbget-bin/www_bget?rn:R04780 OMA VIQGRLW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VIQGRLW PDB 1NI9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1NI9 PDB 2R8T http://www.ebi.ac.uk/pdbe-srv/view/entry/2R8T PDB 3BIG http://www.ebi.ac.uk/pdbe-srv/view/entry/3BIG PDB 3BIH http://www.ebi.ac.uk/pdbe-srv/view/entry/3BIH PDB 3D1R http://www.ebi.ac.uk/pdbe-srv/view/entry/3D1R PDBsum 1NI9 http://www.ebi.ac.uk/pdbsum/1NI9 PDBsum 2R8T http://www.ebi.ac.uk/pdbsum/2R8T PDBsum 3BIG http://www.ebi.ac.uk/pdbsum/3BIG PDBsum 3BIH http://www.ebi.ac.uk/pdbsum/3BIH PDBsum 3D1R http://www.ebi.ac.uk/pdbsum/3D1R PSORT swissprot:GLPX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLPX_ECOLI PSORT-B swissprot:GLPX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLPX_ECOLI PSORT2 swissprot:GLPX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLPX_ECOLI Pfam PF03320 http://pfam.xfam.org/family/PF03320 Phobius swissprot:GLPX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLPX_ECOLI PhylomeDB P0A9C9 http://phylomedb.org/?seqid=P0A9C9 ProteinModelPortal P0A9C9 http://www.proteinmodelportal.org/query/uniprot/P0A9C9 PubMed 10986273 http://www.ncbi.nlm.nih.gov/pubmed/10986273 PubMed 1400248 http://www.ncbi.nlm.nih.gov/pubmed/1400248 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19073594 http://www.ncbi.nlm.nih.gov/pubmed/19073594 PubMed 2834327 http://www.ncbi.nlm.nih.gov/pubmed/2834327 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418360 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418360 RefSeq WP_001250644 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001250644 SMR P0A9C9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9C9 STRING 511145.b3925 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3925&targetmode=cogs STRING COG1494 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1494&targetmode=cogs TIGRFAMs TIGR00330 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00330 UniProtKB GLPX_ECOLI http://www.uniprot.org/uniprot/GLPX_ECOLI UniProtKB-AC P0A9C9 http://www.uniprot.org/uniprot/P0A9C9 charge swissprot:GLPX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLPX_ECOLI eggNOG COG1494 http://eggnogapi.embl.de/nog_data/html/tree/COG1494 eggNOG ENOG4105CBT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CBT epestfind swissprot:GLPX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLPX_ECOLI garnier swissprot:GLPX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLPX_ECOLI helixturnhelix swissprot:GLPX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLPX_ECOLI hmoment swissprot:GLPX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLPX_ECOLI iep swissprot:GLPX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLPX_ECOLI inforesidue swissprot:GLPX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLPX_ECOLI octanol swissprot:GLPX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLPX_ECOLI pepcoil swissprot:GLPX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLPX_ECOLI pepdigest swissprot:GLPX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLPX_ECOLI pepinfo swissprot:GLPX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLPX_ECOLI pepnet swissprot:GLPX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLPX_ECOLI pepstats swissprot:GLPX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLPX_ECOLI pepwheel swissprot:GLPX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLPX_ECOLI pepwindow swissprot:GLPX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLPX_ECOLI sigcleave swissprot:GLPX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLPX_ECOLI ## Database ID URL or Descriptions # AltName DMSC_ECOLI DMSO reductase anchor subunit # BioGrid 4260727 5 # EcoGene EG10234 dmsC # FUNCTION DMSC_ECOLI Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. DmsC anchors the DmsAB dimer to the membrane and stabilizes it. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; ISM:EcoCyc. # GO_component GO:0009390 dimethyl sulfoxide reductase complex; IDA:EcoCyc. # GO_function GO:0009389 dimethyl sulfoxide reductase activity; IDA:EcoCyc. # GO_process GO:0009061 anaerobic respiration; IEP:EcoCyc. # GO_process GO:0019645 anaerobic electron transport chain; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006091 generation of precursor metabolites and energy # InterPro IPR007059 DmsC # KEGG_Brite ko02000 Transporters # Organism DMSC_ECOLI Escherichia coli (strain K12) # PATRIC 32117003 VBIEscCol129921_0926 # PIR S03787 S03787 # Pfam PF04976 DmsC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DMSC_ECOLI Anaerobic dimethyl sulfoxide reductase chain C # RefSeq NP_415416 NC_000913.3 # RefSeq WP_000534637 NZ_LN832404.1 # SIMILARITY To E.coli YnfH. {ECO 0000305}. # SUBCELLULAR LOCATION DMSC_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT DMSC_ECOLI Heterotrimeric enzyme composed of a catalytic heterodimer (DmsAB) and a membrane anchor protein (DmsC). # TCDB 5.A.3.3 the prokaryotic molybdopterin-containing oxidoreductase (pmo) family # eggNOG COG3302 LUCA # eggNOG ENOG4107KGK Bacteria BLAST swissprot:DMSC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DMSC_ECOLI BioCyc ECOL316407:JW0879-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0879-MONOMER BioCyc EcoCyc:DMSC-MONOMER http://biocyc.org/getid?id=EcoCyc:DMSC-MONOMER BioCyc MetaCyc:DMSC-MONOMER http://biocyc.org/getid?id=MetaCyc:DMSC-MONOMER COG COG3302 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3302 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1988.tb00090.x http://dx.doi.org/10.1111/j.1365-2958.1988.tb00090.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J03412 http://www.ebi.ac.uk/ena/data/view/J03412 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0230 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0230 EcoGene EG10234 http://www.ecogene.org/geneInfo.php?eg_id=EG10234 EnsemblBacteria AAC73982 http://www.ensemblgenomes.org/id/AAC73982 EnsemblBacteria AAC73982 http://www.ensemblgenomes.org/id/AAC73982 EnsemblBacteria BAA35628 http://www.ensemblgenomes.org/id/BAA35628 EnsemblBacteria BAA35628 http://www.ensemblgenomes.org/id/BAA35628 EnsemblBacteria BAA35628 http://www.ensemblgenomes.org/id/BAA35628 EnsemblBacteria b0896 http://www.ensemblgenomes.org/id/b0896 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0009390 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009390 GO_function GO:0009389 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009389 GO_process GO:0009061 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009061 GO_process GO:0019645 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019645 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GeneID 945502 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945502 HOGENOM HOG000118381 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118381&db=HOGENOM6 IntAct P18777 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P18777* InterPro IPR007059 http://www.ebi.ac.uk/interpro/entry/IPR007059 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0879 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0879 KEGG_Gene eco:b0896 http://www.genome.jp/dbget-bin/www_bget?eco:b0896 KEGG_Orthology KO:K07308 http://www.genome.jp/dbget-bin/www_bget?KO:K07308 OMA MVRVYNT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MVRVYNT PSORT swissprot:DMSC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DMSC_ECOLI PSORT-B swissprot:DMSC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DMSC_ECOLI PSORT2 swissprot:DMSC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DMSC_ECOLI Pfam PF04976 http://pfam.xfam.org/family/PF04976 Phobius swissprot:DMSC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DMSC_ECOLI ProteinModelPortal P18777 http://www.proteinmodelportal.org/query/uniprot/P18777 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2170332 http://www.ncbi.nlm.nih.gov/pubmed/2170332 PubMed 3062312 http://www.ncbi.nlm.nih.gov/pubmed/3062312 PubMed 8429002 http://www.ncbi.nlm.nih.gov/pubmed/8429002 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415416 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415416 RefSeq WP_000534637 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000534637 STRING 511145.b0896 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0896&targetmode=cogs STRING COG3302 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3302&targetmode=cogs TCDB 5.A.3.3 http://www.tcdb.org/search/result.php?tc=5.A.3.3 UniProtKB DMSC_ECOLI http://www.uniprot.org/uniprot/DMSC_ECOLI UniProtKB-AC P18777 http://www.uniprot.org/uniprot/P18777 charge swissprot:DMSC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DMSC_ECOLI eggNOG COG3302 http://eggnogapi.embl.de/nog_data/html/tree/COG3302 eggNOG ENOG4107KGK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107KGK epestfind swissprot:DMSC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DMSC_ECOLI garnier swissprot:DMSC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DMSC_ECOLI helixturnhelix swissprot:DMSC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DMSC_ECOLI hmoment swissprot:DMSC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DMSC_ECOLI iep swissprot:DMSC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DMSC_ECOLI inforesidue swissprot:DMSC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DMSC_ECOLI octanol swissprot:DMSC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DMSC_ECOLI pepcoil swissprot:DMSC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DMSC_ECOLI pepdigest swissprot:DMSC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DMSC_ECOLI pepinfo swissprot:DMSC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DMSC_ECOLI pepnet swissprot:DMSC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DMSC_ECOLI pepstats swissprot:DMSC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DMSC_ECOLI pepwheel swissprot:DMSC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DMSC_ECOLI pepwindow swissprot:DMSC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DMSC_ECOLI sigcleave swissprot:DMSC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DMSC_ECOLI ## Database ID URL or Descriptions # AltName FRE_ECOLI Aquacobalamin reductase # AltName FRE_ECOLI FMN reductase # AltName FRE_ECOLI Ferrisiderophore reductase C # AltName FRE_ECOLI Riboflavin reductase [NAD(P)H] # AltName NAD(P)H flavin oxidoreductase # BRENDA 1.5.1.41 2026 # BioGrid 4262003 8 # CATALYTIC ACTIVITY FRE_ECOLI 2 cob(II)alamin + NAD(+) + 2 H(2)O = 2 aquacob(III)alamin + NADH. # CATALYTIC ACTIVITY FRE_ECOLI Reduced riboflavin + NAD(P)(+) = riboflavin + NAD(P)H. # CAUTION Was originally assigned to be ubiB. {ECO:0000305|PubMed 1379743}. # EcoGene EG10334 fre # FUNCTION FRE_ECOLI Catalyzes the reduction of soluble flavins by reduced pyridine nucleotides. Seems to reduce the complexed Fe(3+) iron of siderophores to Fe(2+), thus releasing it from the chelator. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008047 enzyme activator activity; IDA:EcoCyc. # GO_function GO:0042602 riboflavin reductase (NADPH) activity; IDA:EcoCyc. # GO_function GO:0047138 aquacobalamin reductase activity; IEA:UniProtKB-EC. # GO_function GO:0052873 FMN reductase (NADPH) activity; TAS:Reactome. # GO_function GO:0052875 riboflavin reductase (NADH) activity; IDA:EcoCyc. # GO_function GO:0071949 FAD binding; IBA:GO_Central. # GO_process GO:0006811 ion transport; IEA:UniProtKB-KW. # GO_process GO:0006979 response to oxidative stress; IMP:EcoCyc. # GO_process GO:0030091 protein repair; IMP:EcoCyc. # GO_process GO:0055072 iron ion homeostasis; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0030234 enzyme regulator activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0042592 homeostatic process # IntAct P0AEN1 13 # InterPro IPR001221 Phe_hydroxylase # InterPro IPR001433 OxRdtase_FAD/NAD-bd # InterPro IPR008333 OxRdtase_FAD-bd_dom # InterPro IPR017927 Fd_Rdtase_FAD-bd # InterPro IPR017938 Riboflavin_synthase-like_b-brl # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00740 Riboflavin metabolism # KEGG_Pathway ko00860 Porphyrin and chlorophyll metabolism # Organism FRE_ECOLI Escherichia coli (strain K12) # PATRIC 32123185 VBIEscCol129921_3958 # PDB 1QFJ X-ray; 2.20 A; A/B/C/D=2-233 # PIR A39434 A39434 # PRINTS PR00410 PHEHYDRXLASE # PROSITE PS51384 FAD_FR # Pfam PF00175 NAD_binding_1 # Pfam PF00970 FAD_binding_6 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FRE_ECOLI NAD(P)H-flavin reductase # RefSeq NP_418286 NC_000913.3 # RefSeq WP_000209826 NZ_LN832404.1 # SIMILARITY Belongs to the Fre/LuxG FAD/NAD(P) flavoprotein oxidoreductase family. {ECO 0000305}. # SIMILARITY Contains 1 FAD-binding FR-type domain. {ECO:0000255|PROSITE-ProRule PRU00716}. # SUBUNIT FRE_ECOLI Monomer. # SUPFAM SSF63380 SSF63380 # eggNOG COG0543 LUCA # eggNOG ENOG4108EX3 Bacteria BLAST swissprot:FRE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FRE_ECOLI BioCyc ECOL316407:JW3820-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3820-MONOMER BioCyc EcoCyc:FMNREDUCT-MONOMER http://biocyc.org/getid?id=EcoCyc:FMNREDUCT-MONOMER BioCyc MetaCyc:FMNREDUCT-MONOMER http://biocyc.org/getid?id=MetaCyc:FMNREDUCT-MONOMER COG COG0543 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0543 DOI 10.1016/0014-5793(92)80452-M http://dx.doi.org/10.1016/0014-5793(92)80452-M DOI 10.1021/bi982849m http://dx.doi.org/10.1021/bi982849m DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.16.1.3 http://www.genome.jp/dbget-bin/www_bget?EC:1.16.1.3 EC_number EC:1.5.1.41 http://www.genome.jp/dbget-bin/www_bget?EC:1.5.1.41 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M61182 http://www.ebi.ac.uk/ena/data/view/M61182 EMBL M74448 http://www.ebi.ac.uk/ena/data/view/M74448 EMBL M85227 http://www.ebi.ac.uk/ena/data/view/M85227 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.16.1.3 http://enzyme.expasy.org/EC/1.16.1.3 ENZYME 1.5.1.41 http://enzyme.expasy.org/EC/1.5.1.41 EchoBASE EB0330 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0330 EcoGene EG10334 http://www.ecogene.org/geneInfo.php?eg_id=EG10334 EnsemblBacteria AAC76847 http://www.ensemblgenomes.org/id/AAC76847 EnsemblBacteria AAC76847 http://www.ensemblgenomes.org/id/AAC76847 EnsemblBacteria BAE77459 http://www.ensemblgenomes.org/id/BAE77459 EnsemblBacteria BAE77459 http://www.ensemblgenomes.org/id/BAE77459 EnsemblBacteria BAE77459 http://www.ensemblgenomes.org/id/BAE77459 EnsemblBacteria b3844 http://www.ensemblgenomes.org/id/b3844 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008047 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008047 GO_function GO:0042602 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042602 GO_function GO:0047138 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047138 GO_function GO:0052873 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052873 GO_function GO:0052875 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052875 GO_function GO:0071949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071949 GO_process GO:0006811 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811 GO_process GO:0006979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979 GO_process GO:0030091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030091 GO_process GO:0055072 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055072 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GeneID 948325 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948325 HOGENOM HOG000269618 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000269618&db=HOGENOM6 InParanoid P0AEN1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEN1 IntAct P0AEN1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEN1* IntEnz 1.16.1.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.16.1.3 IntEnz 1.5.1.41 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.5.1.41 InterPro IPR001221 http://www.ebi.ac.uk/interpro/entry/IPR001221 InterPro IPR001433 http://www.ebi.ac.uk/interpro/entry/IPR001433 InterPro IPR008333 http://www.ebi.ac.uk/interpro/entry/IPR008333 InterPro IPR017927 http://www.ebi.ac.uk/interpro/entry/IPR017927 InterPro IPR017938 http://www.ebi.ac.uk/interpro/entry/IPR017938 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3820 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3820 KEGG_Gene eco:b3844 http://www.genome.jp/dbget-bin/www_bget?eco:b3844 KEGG_Orthology KO:K05368 http://www.genome.jp/dbget-bin/www_bget?KO:K05368 KEGG_Pathway ko00740 http://www.genome.jp/kegg-bin/show_pathway?ko00740 KEGG_Pathway ko00860 http://www.genome.jp/kegg-bin/show_pathway?ko00860 KEGG_Reaction rn:R00097 http://www.genome.jp/dbget-bin/www_bget?rn:R00097 KEGG_Reaction rn:R05705 http://www.genome.jp/dbget-bin/www_bget?rn:R05705 OMA AREWHDA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AREWHDA PDB 1QFJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1QFJ PDBsum 1QFJ http://www.ebi.ac.uk/pdbsum/1QFJ PRINTS PR00410 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00410 PROSITE PS51384 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51384 PSORT swissprot:FRE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FRE_ECOLI PSORT-B swissprot:FRE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FRE_ECOLI PSORT2 swissprot:FRE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FRE_ECOLI Pfam PF00175 http://pfam.xfam.org/family/PF00175 Pfam PF00970 http://pfam.xfam.org/family/PF00970 Phobius swissprot:FRE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FRE_ECOLI PhylomeDB P0AEN1 http://phylomedb.org/?seqid=P0AEN1 ProteinModelPortal P0AEN1 http://www.proteinmodelportal.org/query/uniprot/P0AEN1 PubMed 10353815 http://www.ncbi.nlm.nih.gov/pubmed/10353815 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 1601132 http://www.ncbi.nlm.nih.gov/pubmed/1601132 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2050627 http://www.ncbi.nlm.nih.gov/pubmed/2050627 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418286 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418286 RefSeq WP_000209826 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000209826 SMR P0AEN1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEN1 STRING 511145.b3844 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3844&targetmode=cogs STRING COG0543 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0543&targetmode=cogs SUPFAM SSF63380 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63380 UniProtKB FRE_ECOLI http://www.uniprot.org/uniprot/FRE_ECOLI UniProtKB-AC P0AEN1 http://www.uniprot.org/uniprot/P0AEN1 charge swissprot:FRE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FRE_ECOLI eggNOG COG0543 http://eggnogapi.embl.de/nog_data/html/tree/COG0543 eggNOG ENOG4108EX3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108EX3 epestfind swissprot:FRE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FRE_ECOLI garnier swissprot:FRE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FRE_ECOLI helixturnhelix swissprot:FRE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FRE_ECOLI hmoment swissprot:FRE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FRE_ECOLI iep swissprot:FRE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FRE_ECOLI inforesidue swissprot:FRE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FRE_ECOLI octanol swissprot:FRE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FRE_ECOLI pepcoil swissprot:FRE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FRE_ECOLI pepdigest swissprot:FRE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FRE_ECOLI pepinfo swissprot:FRE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FRE_ECOLI pepnet swissprot:FRE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FRE_ECOLI pepstats swissprot:FRE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FRE_ECOLI pepwheel swissprot:FRE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FRE_ECOLI pepwindow swissprot:FRE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FRE_ECOLI sigcleave swissprot:FRE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FRE_ECOLI ## Database ID URL or Descriptions # BioGrid 4262184 246 # CDD cd06261 TM_PBP2 # EcoGene EG12626 dppC # FUNCTION DPPC_ECOLI Part of the binding-protein-dependent transport system for dipeptides; probably responsible for the translocation of the substrate across the membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; ISS:EcoCyc. # GO_function GO:0022857 transmembrane transporter activity; IBA:GO_Central. # GO_process GO:0015031 protein transport; IEA:UniProtKB-KW. # GO_process GO:0015833 peptide transport; IEA:UniProtKB-KW. # GO_process GO:0055085 transmembrane transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # Gene3D 1.10.3720.10 -; 1. # InterPro IPR000515 MetI-like # InterPro IPR025966 OppC_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00324 Dipeptide transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism DPPC_ECOLI Escherichia coli (strain K12) # PATRIC 32122552 VBIEscCol129921_3654 # PIR S47764 S47764 # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Pfam PF12911 OppC_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DPPC_ECOLI Dipeptide transport system permease protein DppC # RefSeq NP_417999 NC_000913.3 # RefSeq WP_000084677 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION DPPC_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF161098 SSF161098 # eggNOG COG1173 LUCA # eggNOG ENOG4105C2T Bacteria BLAST swissprot:DPPC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DPPC_ECOLI BioCyc ECOL316407:JW3511-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3511-MONOMER BioCyc EcoCyc:DPPC-MONOMER http://biocyc.org/getid?id=EcoCyc:DPPC-MONOMER BioCyc MetaCyc:DPPC-MONOMER http://biocyc.org/getid?id=MetaCyc:DPPC-MONOMER COG COG1173 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1173 DIP DIP-9469N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9469N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1111/j.1365-2958.1994.tb01340.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb01340.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L08399 http://www.ebi.ac.uk/ena/data/view/L08399 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2510 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2510 EcoGene EG12626 http://www.ecogene.org/geneInfo.php?eg_id=EG12626 EnsemblBacteria AAC76567 http://www.ensemblgenomes.org/id/AAC76567 EnsemblBacteria AAC76567 http://www.ensemblgenomes.org/id/AAC76567 EnsemblBacteria BAE77752 http://www.ensemblgenomes.org/id/BAE77752 EnsemblBacteria BAE77752 http://www.ensemblgenomes.org/id/BAE77752 EnsemblBacteria BAE77752 http://www.ensemblgenomes.org/id/BAE77752 EnsemblBacteria b3542 http://www.ensemblgenomes.org/id/b3542 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GO_process GO:0015031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031 GO_process GO:0015833 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015833 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 948064 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948064 HOGENOM HOG000171368 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000171368&db=HOGENOM6 InParanoid P0AEG1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEG1 IntAct P0AEG1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEG1* InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 InterPro IPR025966 http://www.ebi.ac.uk/interpro/entry/IPR025966 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3511 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3511 KEGG_Gene eco:b3542 http://www.genome.jp/dbget-bin/www_bget?eco:b3542 KEGG_Orthology KO:K12370 http://www.genome.jp/dbget-bin/www_bget?KO:K12370 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 MINT MINT-1282303 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1282303 OMA SVMSEKN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SVMSEKN PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:DPPC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DPPC_ECOLI PSORT-B swissprot:DPPC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DPPC_ECOLI PSORT2 swissprot:DPPC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DPPC_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Pfam PF12911 http://pfam.xfam.org/family/PF12911 Phobius swissprot:DPPC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DPPC_ECOLI PhylomeDB P0AEG1 http://phylomedb.org/?seqid=P0AEG1 ProteinModelPortal P0AEG1 http://www.proteinmodelportal.org/query/uniprot/P0AEG1 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7536291 http://www.ncbi.nlm.nih.gov/pubmed/7536291 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417999 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417999 RefSeq WP_000084677 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000084677 STRING 511145.b3542 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3542&targetmode=cogs STRING COG1173 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1173&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 UniProtKB DPPC_ECOLI http://www.uniprot.org/uniprot/DPPC_ECOLI UniProtKB-AC P0AEG1 http://www.uniprot.org/uniprot/P0AEG1 charge swissprot:DPPC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DPPC_ECOLI eggNOG COG1173 http://eggnogapi.embl.de/nog_data/html/tree/COG1173 eggNOG ENOG4105C2T http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C2T epestfind swissprot:DPPC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DPPC_ECOLI garnier swissprot:DPPC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DPPC_ECOLI helixturnhelix swissprot:DPPC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DPPC_ECOLI hmoment swissprot:DPPC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DPPC_ECOLI iep swissprot:DPPC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DPPC_ECOLI inforesidue swissprot:DPPC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DPPC_ECOLI octanol swissprot:DPPC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DPPC_ECOLI pepcoil swissprot:DPPC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DPPC_ECOLI pepdigest swissprot:DPPC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DPPC_ECOLI pepinfo swissprot:DPPC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DPPC_ECOLI pepnet swissprot:DPPC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DPPC_ECOLI pepstats swissprot:DPPC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DPPC_ECOLI pepwheel swissprot:DPPC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DPPC_ECOLI pepwindow swissprot:DPPC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DPPC_ECOLI sigcleave swissprot:DPPC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DPPC_ECOLI ## Database ID URL or Descriptions # BioGrid 4262008 6 # EcoGene EG13753 ydcJ # IntAct P76097 9 # InterPro IPR009770 DUF1338 # Organism YDCJ_ECOLI Escherichia coli (strain K12) # PATRIC 32118132 VBIEscCol129921_1486 # PIR B64894 B64894 # Pfam PF07063 DUF1338 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDCJ_ECOLI Uncharacterized protein YdcJ # RefSeq NP_415940 NC_000913.3 # RefSeq WP_000013789 NZ_LN832404.1 # SIMILARITY To M.tuberculosis Rv3292. {ECO 0000305}. # SMART SM01150 DUF1338 # eggNOG COG5383 LUCA # eggNOG ENOG4105E32 Bacteria BLAST swissprot:YDCJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDCJ_ECOLI BioCyc ECOL316407:JW1419-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1419-MONOMER BioCyc EcoCyc:G6738-MONOMER http://biocyc.org/getid?id=EcoCyc:G6738-MONOMER DIP DIP-11646N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11646N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3516 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3516 EcoGene EG13753 http://www.ecogene.org/geneInfo.php?eg_id=EG13753 EnsemblBacteria AAC74505 http://www.ensemblgenomes.org/id/AAC74505 EnsemblBacteria AAC74505 http://www.ensemblgenomes.org/id/AAC74505 EnsemblBacteria BAE76434 http://www.ensemblgenomes.org/id/BAE76434 EnsemblBacteria BAE76434 http://www.ensemblgenomes.org/id/BAE76434 EnsemblBacteria BAE76434 http://www.ensemblgenomes.org/id/BAE76434 EnsemblBacteria b1423 http://www.ensemblgenomes.org/id/b1423 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945991 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945991 HOGENOM HOG000048569 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000048569&db=HOGENOM6 InParanoid P76097 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76097 IntAct P76097 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76097* InterPro IPR009770 http://www.ebi.ac.uk/interpro/entry/IPR009770 KEGG_Gene ecj:JW1419 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1419 KEGG_Gene eco:b1423 http://www.genome.jp/dbget-bin/www_bget?eco:b1423 OMA PFRIFTS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PFRIFTS PSORT swissprot:YDCJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDCJ_ECOLI PSORT-B swissprot:YDCJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDCJ_ECOLI PSORT2 swissprot:YDCJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDCJ_ECOLI Pfam PF07063 http://pfam.xfam.org/family/PF07063 Phobius swissprot:YDCJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDCJ_ECOLI PhylomeDB P76097 http://phylomedb.org/?seqid=P76097 ProteinModelPortal P76097 http://www.proteinmodelportal.org/query/uniprot/P76097 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415940 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415940 RefSeq WP_000013789 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000013789 SMART SM01150 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01150 SMR P76097 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76097 STRING 511145.b1423 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1423&targetmode=cogs UniProtKB YDCJ_ECOLI http://www.uniprot.org/uniprot/YDCJ_ECOLI UniProtKB-AC P76097 http://www.uniprot.org/uniprot/P76097 charge swissprot:YDCJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDCJ_ECOLI eggNOG COG5383 http://eggnogapi.embl.de/nog_data/html/tree/COG5383 eggNOG ENOG4105E32 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E32 epestfind swissprot:YDCJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDCJ_ECOLI garnier swissprot:YDCJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDCJ_ECOLI helixturnhelix swissprot:YDCJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDCJ_ECOLI hmoment swissprot:YDCJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDCJ_ECOLI iep swissprot:YDCJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDCJ_ECOLI inforesidue swissprot:YDCJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDCJ_ECOLI octanol swissprot:YDCJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDCJ_ECOLI pepcoil swissprot:YDCJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDCJ_ECOLI pepdigest swissprot:YDCJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDCJ_ECOLI pepinfo swissprot:YDCJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDCJ_ECOLI pepnet swissprot:YDCJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDCJ_ECOLI pepstats swissprot:YDCJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDCJ_ECOLI pepwheel swissprot:YDCJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDCJ_ECOLI pepwindow swissprot:YDCJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDCJ_ECOLI sigcleave swissprot:YDCJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDCJ_ECOLI ## Database ID URL or Descriptions # AltName LIVF_ECOLI LIV-I protein F # BioGrid 4261110 10 # EcoGene EG10536 livF # FUNCTION LIVF_ECOLI Component of the leucine-specific transport system. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0015658 branched-chain amino acid transmembrane transporter activity; IMP:EcoCyc. # GO_function GO:0016887 ATPase activity; IEA:InterPro. # GO_process GO:0015803 branched-chain amino acid transport; IMP:EcoCyc. # GO_process GO:0015804 neutral amino acid transport; IEA:GOC. # GO_process GO:0015807 L-amino acid transport; IEA:GOC. # GO_process GO:1902475 L-alpha-amino acid transmembrane transport; IEA:GOC. # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # Gene3D 3.40.50.300 -; 1. # IntAct P22731 13 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # InterPro IPR030660 ABC_branched_ATPase_LivF/BraG # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00237 Branched-chain amino acid transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism LIVF_ECOLI Escherichia coli (strain K12) # PATRIC 32122350 VBIEscCol129921_3552 # PIR S47673 S47673 # PIRSF PIRSF039137 ABC_branched_ATPase # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # Pfam PF00005 ABC_tran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LIVF_ECOLI High-affinity branched-chain amino acid transport ATP-binding protein LivF # RefSeq NP_417911 NC_000913.3 # SEQUENCE CAUTION Sequence=AAB18429.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ABC transporter superfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA # SUPFAM SSF52540 SSF52540 # TCDB 3.A.1.4 the atp-binding cassette (abc) superfamily # eggNOG COG0410 LUCA # eggNOG ENOG4108IV0 Bacteria BLAST swissprot:LIVF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LIVF_ECOLI BioCyc ECOL316407:JW3419-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3419-MONOMER BioCyc EcoCyc:LIVF-MONOMER http://biocyc.org/getid?id=EcoCyc:LIVF-MONOMER BioCyc MetaCyc:LIVF-MONOMER http://biocyc.org/getid?id=MetaCyc:LIVF-MONOMER COG COG0410 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0410 DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J05516 http://www.ebi.ac.uk/ena/data/view/J05516 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0531 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0531 EcoGene EG10536 http://www.ecogene.org/geneInfo.php?eg_id=EG10536 EnsemblBacteria AAC76479 http://www.ensemblgenomes.org/id/AAC76479 EnsemblBacteria AAC76479 http://www.ensemblgenomes.org/id/AAC76479 EnsemblBacteria BAE77839 http://www.ensemblgenomes.org/id/BAE77839 EnsemblBacteria BAE77839 http://www.ensemblgenomes.org/id/BAE77839 EnsemblBacteria BAE77839 http://www.ensemblgenomes.org/id/BAE77839 EnsemblBacteria b3454 http://www.ensemblgenomes.org/id/b3454 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0015658 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015658 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_process GO:0015803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015803 GO_process GO:0015804 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015804 GO_process GO:0015807 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015807 GO_process GO:1902475 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902475 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947961 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947961 InParanoid P22731 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P22731 IntAct P22731 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P22731* InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR030660 http://www.ebi.ac.uk/interpro/entry/IPR030660 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3419 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3419 KEGG_Gene eco:b3454 http://www.genome.jp/dbget-bin/www_bget?eco:b3454 KEGG_Orthology KO:K01996 http://www.genome.jp/dbget-bin/www_bget?KO:K01996 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA MGAFLKT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MGAFLKT PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:LIVF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LIVF_ECOLI PSORT-B swissprot:LIVF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LIVF_ECOLI PSORT2 swissprot:LIVF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LIVF_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Phobius swissprot:LIVF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LIVF_ECOLI PhylomeDB P22731 http://phylomedb.org/?seqid=P22731 ProteinModelPortal P22731 http://www.proteinmodelportal.org/query/uniprot/P22731 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2195019 http://www.ncbi.nlm.nih.gov/pubmed/2195019 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417911 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417911 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P22731 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P22731 STRING 511145.b3454 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3454&targetmode=cogs STRING COG0410 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0410&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.4 http://www.tcdb.org/search/result.php?tc=3.A.1.4 UniProtKB LIVF_ECOLI http://www.uniprot.org/uniprot/LIVF_ECOLI UniProtKB-AC P22731 http://www.uniprot.org/uniprot/P22731 charge swissprot:LIVF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LIVF_ECOLI eggNOG COG0410 http://eggnogapi.embl.de/nog_data/html/tree/COG0410 eggNOG ENOG4108IV0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108IV0 epestfind swissprot:LIVF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LIVF_ECOLI garnier swissprot:LIVF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LIVF_ECOLI helixturnhelix swissprot:LIVF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LIVF_ECOLI hmoment swissprot:LIVF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LIVF_ECOLI iep swissprot:LIVF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LIVF_ECOLI inforesidue swissprot:LIVF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LIVF_ECOLI octanol swissprot:LIVF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LIVF_ECOLI pepcoil swissprot:LIVF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LIVF_ECOLI pepdigest swissprot:LIVF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LIVF_ECOLI pepinfo swissprot:LIVF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LIVF_ECOLI pepnet swissprot:LIVF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LIVF_ECOLI pepstats swissprot:LIVF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LIVF_ECOLI pepwheel swissprot:LIVF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LIVF_ECOLI pepwindow swissprot:LIVF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LIVF_ECOLI sigcleave swissprot:LIVF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LIVF_ECOLI ## Database ID URL or Descriptions # BioGrid 4259269 10 # EcoGene EG12783 yraR # GO_function GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro. # GO_function GO:0051287 NAD binding; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # Gene3D 3.40.50.720 -; 1. # InterPro IPR000534 Semialdehyde_DH_NAD-bd # InterPro IPR016040 NAD(P)-bd_dom # Organism YRAR_ECOLI Escherichia coli (strain K12) # PATRIC 32121722 VBIEscCol129921_3247 # PIR D65105 D65105 # Pfam PF13460 NAD_binding_10 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YRAR_ECOLI Uncharacterized protein YraR # RefSeq NP_417621 NC_000913.3 # RefSeq WP_001300423 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA57955.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY To yeast YER004W. {ECO 0000305}. # SMART SM00859 Semialdhyde_dh # SUPFAM SSF51735 SSF51735 # eggNOG COG0702 LUCA # eggNOG ENOG4105K4T Bacteria BLAST swissprot:YRAR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YRAR_ECOLI BioCyc ECOL316407:JW5528-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5528-MONOMER BioCyc EcoCyc:G7646-MONOMER http://biocyc.org/getid?id=EcoCyc:G7646-MONOMER DIP DIP-12902N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12902N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2636 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2636 EcoGene EG12783 http://www.ecogene.org/geneInfo.php?eg_id=EG12783 EnsemblBacteria AAC76186 http://www.ensemblgenomes.org/id/AAC76186 EnsemblBacteria AAC76186 http://www.ensemblgenomes.org/id/AAC76186 EnsemblBacteria BAE77198 http://www.ensemblgenomes.org/id/BAE77198 EnsemblBacteria BAE77198 http://www.ensemblgenomes.org/id/BAE77198 EnsemblBacteria BAE77198 http://www.ensemblgenomes.org/id/BAE77198 EnsemblBacteria b3152 http://www.ensemblgenomes.org/id/b3152 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016620 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016620 GO_function GO:0051287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051287 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 947667 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947667 HOGENOM HOG000258441 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000258441&db=HOGENOM6 InParanoid P45469 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45469 InterPro IPR000534 http://www.ebi.ac.uk/interpro/entry/IPR000534 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 KEGG_Gene ecj:JW5528 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5528 KEGG_Gene eco:b3152 http://www.genome.jp/dbget-bin/www_bget?eco:b3152 OMA HLENPVG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HLENPVG PSORT swissprot:YRAR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YRAR_ECOLI PSORT-B swissprot:YRAR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YRAR_ECOLI PSORT2 swissprot:YRAR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YRAR_ECOLI Pfam PF13460 http://pfam.xfam.org/family/PF13460 Phobius swissprot:YRAR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YRAR_ECOLI PhylomeDB P45469 http://phylomedb.org/?seqid=P45469 ProteinModelPortal P45469 http://www.proteinmodelportal.org/query/uniprot/P45469 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417621 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417621 RefSeq WP_001300423 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300423 SMART SM00859 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00859 SMR P45469 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45469 STRING 511145.b3152 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3152&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB YRAR_ECOLI http://www.uniprot.org/uniprot/YRAR_ECOLI UniProtKB-AC P45469 http://www.uniprot.org/uniprot/P45469 charge swissprot:YRAR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YRAR_ECOLI eggNOG COG0702 http://eggnogapi.embl.de/nog_data/html/tree/COG0702 eggNOG ENOG4105K4T http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K4T epestfind swissprot:YRAR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YRAR_ECOLI garnier swissprot:YRAR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YRAR_ECOLI helixturnhelix swissprot:YRAR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YRAR_ECOLI hmoment swissprot:YRAR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YRAR_ECOLI iep swissprot:YRAR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YRAR_ECOLI inforesidue swissprot:YRAR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YRAR_ECOLI octanol swissprot:YRAR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YRAR_ECOLI pepcoil swissprot:YRAR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YRAR_ECOLI pepdigest swissprot:YRAR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YRAR_ECOLI pepinfo swissprot:YRAR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YRAR_ECOLI pepnet swissprot:YRAR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YRAR_ECOLI pepstats swissprot:YRAR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YRAR_ECOLI pepwheel swissprot:YRAR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YRAR_ECOLI pepwindow swissprot:YRAR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YRAR_ECOLI sigcleave swissprot:YRAR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YRAR_ECOLI ## Database ID URL or Descriptions # CAUTION There is no equivalent of this gene in strain K12 / MG1655. {ECO 0000305}. # FUNCTION INC10_ECOLI Involved in the transposition of the insertion sequence IS2. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 1.10.10.60 -; 1. # InterPro IPR002514 Transposase_8 # InterPro IPR009057 Homeodomain-like # Organism INC10_ECOLI Escherichia coli (strain K12) # Pfam PF01527 HTH_Tnp_1 # RecName INC10_ECOLI Transposase InsC for insertion element IS2-10 # RefSeq WP_000567766 NZ_LN832404.1 # SIMILARITY Belongs to the transposase 8 family. {ECO 0000305}. # SUPFAM SSF46689 SSF46689 # eggNOG COG2963 LUCA # eggNOG ENOG4108ZQS Bacteria BLAST swissprot:INC10_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INC10_ECOLI DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EnsemblBacteria BAA16005 http://www.ensemblgenomes.org/id/BAA16005 EnsemblBacteria BAA16005 http://www.ensemblgenomes.org/id/BAA16005 EnsemblBacteria BAA16005 http://www.ensemblgenomes.org/id/BAA16005 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 InterPro IPR002514 http://www.ebi.ac.uk/interpro/entry/IPR002514 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 KEGG_Gene ecj:JW5919 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5919 OMA RRRWTTE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RRRWTTE PSORT swissprot:INC10_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INC10_ECOLI PSORT-B swissprot:INC10_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INC10_ECOLI PSORT2 swissprot:INC10_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INC10_ECOLI Pfam PF01527 http://pfam.xfam.org/family/PF01527 Phobius swissprot:INC10_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INC10_ECOLI PhylomeDB P0CF49 http://phylomedb.org/?seqid=P0CF49 ProteinModelPortal P0CF49 http://www.proteinmodelportal.org/query/uniprot/P0CF49 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 RefSeq WP_000567766 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000567766 STRING 511145.b4272 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4272&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 UniProtKB INC10_ECOLI http://www.uniprot.org/uniprot/INC10_ECOLI UniProtKB-AC P0CF49 http://www.uniprot.org/uniprot/P0CF49 charge swissprot:INC10_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INC10_ECOLI eggNOG COG2963 http://eggnogapi.embl.de/nog_data/html/tree/COG2963 eggNOG ENOG4108ZQS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZQS epestfind swissprot:INC10_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INC10_ECOLI garnier swissprot:INC10_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INC10_ECOLI helixturnhelix swissprot:INC10_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INC10_ECOLI hmoment swissprot:INC10_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INC10_ECOLI iep swissprot:INC10_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INC10_ECOLI inforesidue swissprot:INC10_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INC10_ECOLI octanol swissprot:INC10_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INC10_ECOLI pepcoil swissprot:INC10_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INC10_ECOLI pepdigest swissprot:INC10_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INC10_ECOLI pepinfo swissprot:INC10_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INC10_ECOLI pepnet swissprot:INC10_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INC10_ECOLI pepstats swissprot:INC10_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INC10_ECOLI pepwheel swissprot:INC10_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INC10_ECOLI pepwindow swissprot:INC10_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INC10_ECOLI sigcleave swissprot:INC10_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INC10_ECOLI ## Database ID URL or Descriptions # BioGrid 4259171 6 # EcoGene EG10594 mglC # FUNCTION MGLC_ECOLI Part of the binding-protein-dependent transport system for galactoside. Probably responsible for the translocation of the substrate across the membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IBA:GO_Central. # GO_function GO:0015145 monosaccharide transmembrane transporter activity; IBA:GO_Central. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006950 response to stress # InterPro IPR001851 ABC_transp_permease # InterPro IPR030158 MglC # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00214 Methyl-galactoside transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism MGLC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR32196:SF18 PTHR32196:SF18 # PATRIC 32119641 VBIEscCol129921_2231 # PIR C37277 C37277 # Pfam PF02653 BPD_transp_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MGLC_ECOLI Galactoside transport system permease protein MglC # RefSeq NP_416653 NC_000913.3 # RefSeq WP_001275118 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION MGLC_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 3.A.1.2 the atp-binding cassette (abc) superfamily # eggNOG COG4211 LUCA # eggNOG ENOG4108HWV Bacteria BLAST swissprot:MGLC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MGLC_ECOLI BioCyc ECOL316407:JW2135-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2135-MONOMER BioCyc EcoCyc:MGLC-MONOMER http://biocyc.org/getid?id=EcoCyc:MGLC-MONOMER BioCyc MetaCyc:MGLC-MONOMER http://biocyc.org/getid?id=MetaCyc:MGLC-MONOMER COG COG4211 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4211 DOI 10.1007/BF00267469 http://dx.doi.org/10.1007/BF00267469 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M59444 http://www.ebi.ac.uk/ena/data/view/M59444 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0589 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0589 EcoGene EG10594 http://www.ecogene.org/geneInfo.php?eg_id=EG10594 EnsemblBacteria AAC75209 http://www.ensemblgenomes.org/id/AAC75209 EnsemblBacteria AAC75209 http://www.ensemblgenomes.org/id/AAC75209 EnsemblBacteria BAE76625 http://www.ensemblgenomes.org/id/BAE76625 EnsemblBacteria BAE76625 http://www.ensemblgenomes.org/id/BAE76625 EnsemblBacteria BAE76625 http://www.ensemblgenomes.org/id/BAE76625 EnsemblBacteria b2148 http://www.ensemblgenomes.org/id/b2148 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015145 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 949039 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949039 HOGENOM HOG000212232 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000212232&db=HOGENOM6 InParanoid P23200 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23200 InterPro IPR001851 http://www.ebi.ac.uk/interpro/entry/IPR001851 InterPro IPR030158 http://www.ebi.ac.uk/interpro/entry/IPR030158 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2135 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2135 KEGG_Gene eco:b2148 http://www.genome.jp/dbget-bin/www_bget?eco:b2148 KEGG_Orthology KO:K10541 http://www.genome.jp/dbget-bin/www_bget?KO:K10541 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA AFVWILW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AFVWILW PANTHER PTHR32196:SF18 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32196:SF18 PSORT swissprot:MGLC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MGLC_ECOLI PSORT-B swissprot:MGLC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MGLC_ECOLI PSORT2 swissprot:MGLC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MGLC_ECOLI Pfam PF02653 http://pfam.xfam.org/family/PF02653 Phobius swissprot:MGLC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MGLC_ECOLI PhylomeDB P23200 http://phylomedb.org/?seqid=P23200 ProteinModelPortal P23200 http://www.proteinmodelportal.org/query/uniprot/P23200 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1719366 http://www.ncbi.nlm.nih.gov/pubmed/1719366 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416653 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416653 RefSeq WP_001275118 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001275118 STRING 511145.b2148 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2148&targetmode=cogs STRING COG4211 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4211&targetmode=cogs TCDB 3.A.1.2 http://www.tcdb.org/search/result.php?tc=3.A.1.2 UniProtKB MGLC_ECOLI http://www.uniprot.org/uniprot/MGLC_ECOLI UniProtKB-AC P23200 http://www.uniprot.org/uniprot/P23200 charge swissprot:MGLC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MGLC_ECOLI eggNOG COG4211 http://eggnogapi.embl.de/nog_data/html/tree/COG4211 eggNOG ENOG4108HWV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108HWV epestfind swissprot:MGLC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MGLC_ECOLI garnier swissprot:MGLC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MGLC_ECOLI helixturnhelix swissprot:MGLC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MGLC_ECOLI hmoment swissprot:MGLC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MGLC_ECOLI iep swissprot:MGLC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MGLC_ECOLI inforesidue swissprot:MGLC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MGLC_ECOLI octanol swissprot:MGLC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MGLC_ECOLI pepcoil swissprot:MGLC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MGLC_ECOLI pepdigest swissprot:MGLC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MGLC_ECOLI pepinfo swissprot:MGLC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MGLC_ECOLI pepnet swissprot:MGLC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MGLC_ECOLI pepstats swissprot:MGLC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MGLC_ECOLI pepwheel swissprot:MGLC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MGLC_ECOLI pepwindow swissprot:MGLC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MGLC_ECOLI sigcleave swissprot:MGLC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MGLC_ECOLI ## Database ID URL or Descriptions # BioGrid 4262093 10 # EcoGene EG11923 yjbE # GO_process GO:0044010 single-species biofilm formation; IMP:EcoCyc. # GO_process GO:0045226 extracellular polysaccharide biosynthetic process; IMP:EcoCyc. # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # InterPro IPR025858 YjbE # Organism YJBE_ECOLI Escherichia coli (strain K12) # PATRIC 32123581 VBIEscCol129921_4139 # PIR A65210 A65210 # Pfam PF11106 YjbE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJBE_ECOLI Uncharacterized protein YjbE # RefSeq NP_418450 NC_000913.3 # RefSeq WP_000757333 NZ_LN832404.1 BLAST swissprot:YJBE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJBE_ECOLI BioCyc ECOL316407:JW3986-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3986-MONOMER BioCyc EcoCyc:EG11923-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11923-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1867 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1867 EcoGene EG11923 http://www.ecogene.org/geneInfo.php?eg_id=EG11923 EnsemblBacteria AAC76996 http://www.ensemblgenomes.org/id/AAC76996 EnsemblBacteria AAC76996 http://www.ensemblgenomes.org/id/AAC76996 EnsemblBacteria BAE78028 http://www.ensemblgenomes.org/id/BAE78028 EnsemblBacteria BAE78028 http://www.ensemblgenomes.org/id/BAE78028 EnsemblBacteria BAE78028 http://www.ensemblgenomes.org/id/BAE78028 EnsemblBacteria b4026 http://www.ensemblgenomes.org/id/b4026 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0044010 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044010 GO_process GO:0045226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045226 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 948534 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948534 InterPro IPR025858 http://www.ebi.ac.uk/interpro/entry/IPR025858 KEGG_Gene ecj:JW3986 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3986 KEGG_Gene eco:b4026 http://www.genome.jp/dbget-bin/www_bget?eco:b4026 OMA CAAPVET http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CAAPVET PSORT swissprot:YJBE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJBE_ECOLI PSORT-B swissprot:YJBE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJBE_ECOLI PSORT2 swissprot:YJBE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJBE_ECOLI Pfam PF11106 http://pfam.xfam.org/family/PF11106 Phobius swissprot:YJBE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJBE_ECOLI ProteinModelPortal P0AF45 http://www.proteinmodelportal.org/query/uniprot/P0AF45 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418450 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418450 RefSeq WP_000757333 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000757333 STRING 511145.b4026 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4026&targetmode=cogs UniProtKB YJBE_ECOLI http://www.uniprot.org/uniprot/YJBE_ECOLI UniProtKB-AC P0AF45 http://www.uniprot.org/uniprot/P0AF45 charge swissprot:YJBE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJBE_ECOLI epestfind swissprot:YJBE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJBE_ECOLI garnier swissprot:YJBE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJBE_ECOLI helixturnhelix swissprot:YJBE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJBE_ECOLI hmoment swissprot:YJBE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJBE_ECOLI iep swissprot:YJBE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJBE_ECOLI inforesidue swissprot:YJBE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJBE_ECOLI octanol swissprot:YJBE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJBE_ECOLI pepcoil swissprot:YJBE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJBE_ECOLI pepdigest swissprot:YJBE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJBE_ECOLI pepinfo swissprot:YJBE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJBE_ECOLI pepnet swissprot:YJBE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJBE_ECOLI pepstats swissprot:YJBE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJBE_ECOLI pepwheel swissprot:YJBE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJBE_ECOLI pepwindow swissprot:YJBE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJBE_ECOLI sigcleave swissprot:YJBE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJBE_ECOLI ## Database ID URL or Descriptions # EcoGene EG14177 yffP # Organism YFFP_ECOLI Escherichia coli (strain K12) # PATRIC 32120275 VBIEscCol129921_2540 # PIR F65019 F65019 # Proteomes UP000000625 Chromosome # RecName YFFP_ECOLI Uncharacterized protein YffP # RefSeq NP_416942 NC_000913.3 # RefSeq WP_000052882 NZ_CP014272.1 BLAST swissprot:YFFP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFFP_ECOLI BioCyc EcoCyc:G7277-MONOMER http://biocyc.org/getid?id=EcoCyc:G7277-MONOMER DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3929 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3929 EcoGene EG14177 http://www.ecogene.org/geneInfo.php?eg_id=EG14177 EnsemblBacteria AAC75500 http://www.ensemblgenomes.org/id/AAC75500 EnsemblBacteria AAC75500 http://www.ensemblgenomes.org/id/AAC75500 EnsemblBacteria b2447 http://www.ensemblgenomes.org/id/b2447 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946928 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946928 KEGG_Gene eco:b2447 http://www.genome.jp/dbget-bin/www_bget?eco:b2447 PSORT swissprot:YFFP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFFP_ECOLI PSORT-B swissprot:YFFP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFFP_ECOLI PSORT2 swissprot:YFFP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFFP_ECOLI Phobius swissprot:YFFP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFFP_ECOLI ProteinModelPortal P76547 http://www.proteinmodelportal.org/query/uniprot/P76547 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416942 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416942 RefSeq WP_000052882 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000052882 SMR P76547 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76547 STRING 511145.b2447 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2447&targetmode=cogs UniProtKB YFFP_ECOLI http://www.uniprot.org/uniprot/YFFP_ECOLI UniProtKB-AC P76547 http://www.uniprot.org/uniprot/P76547 charge swissprot:YFFP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFFP_ECOLI epestfind swissprot:YFFP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFFP_ECOLI garnier swissprot:YFFP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFFP_ECOLI helixturnhelix swissprot:YFFP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFFP_ECOLI hmoment swissprot:YFFP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFFP_ECOLI iep swissprot:YFFP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFFP_ECOLI inforesidue swissprot:YFFP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFFP_ECOLI octanol swissprot:YFFP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFFP_ECOLI pepcoil swissprot:YFFP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFFP_ECOLI pepdigest swissprot:YFFP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFFP_ECOLI pepinfo swissprot:YFFP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFFP_ECOLI pepnet swissprot:YFFP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFFP_ECOLI pepstats swissprot:YFFP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFFP_ECOLI pepwheel swissprot:YFFP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFFP_ECOLI pepwindow swissprot:YFFP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFFP_ECOLI sigcleave swissprot:YFFP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFFP_ECOLI ## Database ID URL or Descriptions # AltName LONH_ECOLI ATP-dependent protease La homolog # BioGrid 4260030 9 # DOMAIN LONH_ECOLI Lacks the ATP-binding domain. # EcoGene EG13718 ycbZ # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0003697 single-stranded DNA binding; IBA:GO_Central. # GO_function GO:0004176 ATP-dependent peptidase activity; IBA:GO_Central. # GO_function GO:0004252 serine-type endopeptidase activity; IEA:InterPro. # GO_function GO:0005524 ATP binding; IEA:InterPro. # GO_function GO:0070361 mitochondrial light strand promoter anti-sense binding; IBA:GO_Central. # GO_process GO:0006515 misfolded or incompletely synthesized protein catabolic process; IBA:GO_Central. # GO_process GO:0051131 chaperone-mediated protein complex assembly; IBA:GO_Central. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0008150 biological_process # Gene3D 3.30.230.10 -; 1. # InterPro IPR008269 Pept_S16_C # InterPro IPR014721 Ribosomal_S5_D2-typ_fold_subgr # InterPro IPR020568 Ribosomal_S5_D2-typ_fold # InterPro IPR027065 Lon_Prtase # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # Organism LONH_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10046 PTHR10046 # PATRIC 32117129 VBIEscCol129921_0989 # PIR B64836 B64836 # PROSITE PS51786 LON_PROTEOLYTIC # Pfam PF05362 Lon_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LONH_ECOLI Putative Lon protease homolog # RefSeq NP_415475 NC_000913.3 # RefSeq WP_000156518 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase S16 family. {ECO:0000255|PROSITE-ProRule PRU01122}. # SIMILARITY Contains 1 Lon proteolytic domain. {ECO:0000255|PROSITE-ProRule PRU01122}. # SUPFAM SSF54211 SSF54211 # eggNOG COG1067 LUCA # eggNOG ENOG4105DAN Bacteria BLAST swissprot:LONH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LONH_ECOLI BioCyc ECOL316407:JW0938-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0938-MONOMER BioCyc EcoCyc:G6493-MONOMER http://biocyc.org/getid?id=EcoCyc:G6493-MONOMER COG COG1067 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1067 DIP DIP-11487N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11487N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.21.- http://www.genome.jp/dbget-bin/www_bget?EC:3.4.21.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.4.21.- http://enzyme.expasy.org/EC/3.4.21.- EchoBASE EB3482 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3482 EcoGene EG13718 http://www.ecogene.org/geneInfo.php?eg_id=EG13718 EnsemblBacteria AAC74041 http://www.ensemblgenomes.org/id/AAC74041 EnsemblBacteria AAC74041 http://www.ensemblgenomes.org/id/AAC74041 EnsemblBacteria BAA35713 http://www.ensemblgenomes.org/id/BAA35713 EnsemblBacteria BAA35713 http://www.ensemblgenomes.org/id/BAA35713 EnsemblBacteria BAA35713 http://www.ensemblgenomes.org/id/BAA35713 EnsemblBacteria b0955 http://www.ensemblgenomes.org/id/b0955 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003697 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003697 GO_function GO:0004176 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004176 GO_function GO:0004252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004252 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0070361 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070361 GO_process GO:0006515 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006515 GO_process GO:0051131 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051131 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.30.230.10 http://www.cathdb.info/version/latest/superfamily/3.30.230.10 GeneID 945569 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945569 HOGENOM HOG000277817 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000277817&db=HOGENOM6 InParanoid P75867 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75867 IntEnz 3.4.21 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.21 InterPro IPR008269 http://www.ebi.ac.uk/interpro/entry/IPR008269 InterPro IPR014721 http://www.ebi.ac.uk/interpro/entry/IPR014721 InterPro IPR020568 http://www.ebi.ac.uk/interpro/entry/IPR020568 InterPro IPR027065 http://www.ebi.ac.uk/interpro/entry/IPR027065 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW0938 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0938 KEGG_Gene eco:b0955 http://www.genome.jp/dbget-bin/www_bget?eco:b0955 KEGG_Orthology KO:K04770 http://www.genome.jp/dbget-bin/www_bget?KO:K04770 OMA GFFTICQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GFFTICQ PANTHER PTHR10046 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10046 PROSITE PS51786 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51786 PSORT swissprot:LONH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LONH_ECOLI PSORT-B swissprot:LONH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LONH_ECOLI PSORT2 swissprot:LONH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LONH_ECOLI Pfam PF05362 http://pfam.xfam.org/family/PF05362 Phobius swissprot:LONH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LONH_ECOLI PhylomeDB P75867 http://phylomedb.org/?seqid=P75867 ProteinModelPortal P75867 http://www.proteinmodelportal.org/query/uniprot/P75867 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415475 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415475 RefSeq WP_000156518 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000156518 SMR P75867 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75867 STRING 511145.b0955 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0955&targetmode=cogs STRING COG1067 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1067&targetmode=cogs SUPFAM SSF54211 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54211 UniProtKB LONH_ECOLI http://www.uniprot.org/uniprot/LONH_ECOLI UniProtKB-AC P75867 http://www.uniprot.org/uniprot/P75867 charge swissprot:LONH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LONH_ECOLI eggNOG COG1067 http://eggnogapi.embl.de/nog_data/html/tree/COG1067 eggNOG ENOG4105DAN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DAN epestfind swissprot:LONH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LONH_ECOLI garnier swissprot:LONH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LONH_ECOLI helixturnhelix swissprot:LONH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LONH_ECOLI hmoment swissprot:LONH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LONH_ECOLI iep swissprot:LONH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LONH_ECOLI inforesidue swissprot:LONH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LONH_ECOLI octanol swissprot:LONH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LONH_ECOLI pepcoil swissprot:LONH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LONH_ECOLI pepdigest swissprot:LONH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LONH_ECOLI pepinfo swissprot:LONH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LONH_ECOLI pepnet swissprot:LONH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LONH_ECOLI pepstats swissprot:LONH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LONH_ECOLI pepwheel swissprot:LONH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LONH_ECOLI pepwindow swissprot:LONH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LONH_ECOLI sigcleave swissprot:LONH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LONH_ECOLI ## Database ID URL or Descriptions # DOMAIN RHSC_ECOLI Each rhs appears to consist of a highly conserved 141 kDa amino fragment followed by a highly divergent C-terminus. # EcoGene EG10848 rhsC # FUNCTION RHSC_ECOLI Rhs elements have a nonessential function. They may play an important role in the natural ecology of the cell. # GO_process GO:0097264 self proteolysis; IEA:InterPro. # GOslim_process GO:0008150 biological_process # INTERACTION RHSC_ECOLI P23869 ppiB; NbExp=4; IntAct=EBI-546818, EBI-555935; # IntAct P16918 33 # InterPro IPR001826 RHS # InterPro IPR006530 YD # InterPro IPR022385 Rhs_assc_core # InterPro IPR031325 RHS_repeat # Organism RHSC_ECOLI Escherichia coli (strain K12) # PATRIC 32116597 VBIEscCol129921_0731 # PIR C64805 C64805 # PIR E65145 E65145 # PRINTS PR00394 RHSPROTEIN # Pfam PF03527 RHS # Pfam PF05593 RHS_repeat; 7 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RHSC_ECOLI Protein RhsC # RefSeq NP_415229 NC_000913.3 # RefSeq WP_000015200 NZ_LN832404.1 # SIMILARITY Belongs to the RHS family. {ECO 0000305}. # TIGRFAMs TIGR01643 YD_repeat_2x; 6 # TIGRFAMs TIGR03696 Rhs_assc_core # eggNOG COG3209 LUCA # eggNOG ENOG4105CNA Bacteria BLAST swissprot:RHSC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RHSC_ECOLI BioCyc ECOL316407:JW0689-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0689-MONOMER BioCyc EcoCyc:EG10848-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10848-MONOMER DIP DIP-10701N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10701N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1994.tb01074.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb01074.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L02373 http://www.ebi.ac.uk/ena/data/view/L02373 EMBL L19044 http://www.ebi.ac.uk/ena/data/view/L19044 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0841 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0841 EcoGene EG10848 http://www.ecogene.org/geneInfo.php?eg_id=EG10848 EnsemblBacteria AAC73794 http://www.ensemblgenomes.org/id/AAC73794 EnsemblBacteria AAC73794 http://www.ensemblgenomes.org/id/AAC73794 EnsemblBacteria BAA35359 http://www.ensemblgenomes.org/id/BAA35359 EnsemblBacteria BAA35359 http://www.ensemblgenomes.org/id/BAA35359 EnsemblBacteria BAA35359 http://www.ensemblgenomes.org/id/BAA35359 EnsemblBacteria b0700 http://www.ensemblgenomes.org/id/b0700 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0097264 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097264 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 945306 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945306 HOGENOM HOG000225201 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000225201&db=HOGENOM6 InParanoid P16918 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P16918 IntAct P16918 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P16918* InterPro IPR001826 http://www.ebi.ac.uk/interpro/entry/IPR001826 InterPro IPR006530 http://www.ebi.ac.uk/interpro/entry/IPR006530 InterPro IPR022385 http://www.ebi.ac.uk/interpro/entry/IPR022385 InterPro IPR031325 http://www.ebi.ac.uk/interpro/entry/IPR031325 KEGG_Gene ecj:JW0689 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0689 KEGG_Gene eco:b0700 http://www.genome.jp/dbget-bin/www_bget?eco:b0700 MINT MINT-1305459 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1305459 OMA AATHQKY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AATHQKY PRINTS PR00394 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00394 PSORT swissprot:RHSC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RHSC_ECOLI PSORT-B swissprot:RHSC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RHSC_ECOLI PSORT2 swissprot:RHSC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RHSC_ECOLI Pfam PF03527 http://pfam.xfam.org/family/PF03527 Pfam PF05593 http://pfam.xfam.org/family/PF05593 Phobius swissprot:RHSC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RHSC_ECOLI PhylomeDB P16918 http://phylomedb.org/?seqid=P16918 ProteinModelPortal P16918 http://www.proteinmodelportal.org/query/uniprot/P16918 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2403547 http://www.ncbi.nlm.nih.gov/pubmed/2403547 PubMed 2644231 http://www.ncbi.nlm.nih.gov/pubmed/2644231 PubMed 7934896 http://www.ncbi.nlm.nih.gov/pubmed/7934896 PubMed 8387990 http://www.ncbi.nlm.nih.gov/pubmed/8387990 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415229 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415229 RefSeq WP_000015200 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000015200 SMR P16918 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P16918 STRING 511145.b0700 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0700&targetmode=cogs TIGRFAMs TIGR01643 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01643 TIGRFAMs TIGR03696 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03696 UniProtKB RHSC_ECOLI http://www.uniprot.org/uniprot/RHSC_ECOLI UniProtKB-AC P16918 http://www.uniprot.org/uniprot/P16918 charge swissprot:RHSC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RHSC_ECOLI eggNOG COG3209 http://eggnogapi.embl.de/nog_data/html/tree/COG3209 eggNOG ENOG4105CNA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CNA epestfind swissprot:RHSC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RHSC_ECOLI garnier swissprot:RHSC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RHSC_ECOLI helixturnhelix swissprot:RHSC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RHSC_ECOLI hmoment swissprot:RHSC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RHSC_ECOLI iep swissprot:RHSC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RHSC_ECOLI inforesidue swissprot:RHSC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RHSC_ECOLI octanol swissprot:RHSC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RHSC_ECOLI pepcoil swissprot:RHSC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RHSC_ECOLI pepdigest swissprot:RHSC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RHSC_ECOLI pepinfo swissprot:RHSC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RHSC_ECOLI pepnet swissprot:RHSC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RHSC_ECOLI pepstats swissprot:RHSC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RHSC_ECOLI pepwheel swissprot:RHSC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RHSC_ECOLI pepwindow swissprot:RHSC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RHSC_ECOLI sigcleave swissprot:RHSC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RHSC_ECOLI ## Database ID URL or Descriptions # BioGrid 4262769 25 # CATALYTIC ACTIVITY T1RK_ECOLI Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates; ATP is simultaneously hydrolyzed. # EcoGene EG10459 hsdR # FUNCTION T1RK_ECOLI The EcoKI enzyme recognizes 5'-AACN(6)GTGC-3'. Subunit R is required for both nuclease and ATPase activities, but not for modification. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004386 helicase activity; IEA:UniProtKB-KW. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0009035 Type I site-specific deoxyribonuclease activity; IEA:UniProtKB-EC. # GO_process GO:0009307 DNA restriction-modification system; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004386 helicase activity # GOslim_function GO:0004518 nuclease activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # Gene3D 3.40.50.300 -; 2. # IntAct P08956 15 # InterPro IPR001650 Helicase_C # InterPro IPR006935 Helicase/UvrB_N # InterPro IPR007409 Restrct_endonuc_type1_HsdR_N # InterPro IPR013670 EcoEI_R_C_dom # InterPro IPR014001 Helicase_ATP-bd # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko01000 Enzymes # MISCELLANEOUS T1RK_ECOLI Type I restriction and modification enzymes are complex, multifunctional systems which require ATP, S-adenosyl methionine and magnesium as cofactors and, in addition to their endonucleolytic and methylase activities, are potent DNA-dependent ATPases. # Organism T1RK_ECOLI Escherichia coli (strain K12) # PATRIC 32124306 VBIEscCol129921_4496 # PIR S56576 NDECKR # PROSITE PS51192 HELICASE_ATP_BIND_1 # PROSITE PS51194 HELICASE_CTER # Pfam PF00271 Helicase_C # Pfam PF04313 HSDR_N # Pfam PF04851 ResIII # Pfam PF08463 EcoEI_R_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # REBASE 980 EcoKI # RecName T1RK_ECOLI Type I restriction enzyme EcoKI R protein # RefSeq NP_418770 NC_000913.3 # RefSeq WP_000981388 NZ_LN832404.1 # SEQUENCE CAUTION T1RK_ECOLI Sequence=AAA97247.1; Type=Erroneous initiation; Evidence={ECO 0000305}; Sequence=BAE78340.1; Type=Erroneous initiation; Evidence={ECO 0000305}; Sequence=CAA29791.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=CAA29791.1; Type=Frameshift; Positions=1066; Evidence={ECO 0000305}; Sequence=CAA38116.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the HsdR family. {ECO 0000305}. # SIMILARITY Contains 1 helicase ATP-binding domain. {ECO:0000255|PROSITE-ProRule PRU00541}. # SIMILARITY Contains 1 helicase C-terminal domain. {ECO:0000255|PROSITE-ProRule PRU00542}. # SMART SM00487 DEXDc # SMART SM00490 HELICc # SUBUNIT T1RK_ECOLI The type I restriction/modification system is composed of three polypeptides R, M and S. # SUPFAM SSF52540 SSF52540; 2 # TCDB 3.A.17.1 the phage t7 injectisome (t7 injectisome) family # eggNOG COG4096 LUCA # eggNOG ENOG4107SCJ Bacteria BLAST swissprot:T1RK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:T1RK_ECOLI BioCyc ECOL316407:JW4313-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4313-MONOMER BioCyc EcoCyc:EG10459-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10459-MONOMER BioCyc MetaCyc:EG10459-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10459-MONOMER COG COG0610 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0610 DIP DIP-9944N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9944N DOI 10.1016/0022-2836(87)90303-2 http://dx.doi.org/10.1016/0022-2836(87)90303-2 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.21.3 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.21.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X06545 http://www.ebi.ac.uk/ena/data/view/X06545 EMBL X54198 http://www.ebi.ac.uk/ena/data/view/X54198 ENZYME 3.1.21.3 http://enzyme.expasy.org/EC/3.1.21.3 EchoBASE EB0454 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0454 EcoGene EG10459 http://www.ecogene.org/geneInfo.php?eg_id=EG10459 EnsemblBacteria AAC77306 http://www.ensemblgenomes.org/id/AAC77306 EnsemblBacteria AAC77306 http://www.ensemblgenomes.org/id/AAC77306 EnsemblBacteria BAE78340 http://www.ensemblgenomes.org/id/BAE78340 EnsemblBacteria BAE78340 http://www.ensemblgenomes.org/id/BAE78340 EnsemblBacteria BAE78340 http://www.ensemblgenomes.org/id/BAE78340 EnsemblBacteria b4350 http://www.ensemblgenomes.org/id/b4350 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004386 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0009035 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009035 GO_process GO:0009307 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009307 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004386 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948878 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948878 HOGENOM HOG000295053 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000295053&db=HOGENOM6 InParanoid P08956 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P08956 IntAct P08956 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P08956* IntEnz 3.1.21.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.21.3 InterPro IPR001650 http://www.ebi.ac.uk/interpro/entry/IPR001650 InterPro IPR006935 http://www.ebi.ac.uk/interpro/entry/IPR006935 InterPro IPR007409 http://www.ebi.ac.uk/interpro/entry/IPR007409 InterPro IPR013670 http://www.ebi.ac.uk/interpro/entry/IPR013670 InterPro IPR014001 http://www.ebi.ac.uk/interpro/entry/IPR014001 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4313 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4313 KEGG_Gene eco:b4350 http://www.genome.jp/dbget-bin/www_bget?eco:b4350 KEGG_Orthology KO:K01153 http://www.genome.jp/dbget-bin/www_bget?KO:K01153 MINT MINT-1243362 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1243362 PROSITE PS51192 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51192 PROSITE PS51194 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51194 PSORT swissprot:T1RK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:T1RK_ECOLI PSORT-B swissprot:T1RK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:T1RK_ECOLI PSORT2 swissprot:T1RK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:T1RK_ECOLI Pfam PF00271 http://pfam.xfam.org/family/PF00271 Pfam PF04313 http://pfam.xfam.org/family/PF04313 Pfam PF04851 http://pfam.xfam.org/family/PF04851 Pfam PF08463 http://pfam.xfam.org/family/PF08463 Phobius swissprot:T1RK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:T1RK_ECOLI PhylomeDB P08956 http://phylomedb.org/?seqid=P08956 ProteinModelPortal P08956 http://www.proteinmodelportal.org/query/uniprot/P08956 PubMed 1650347 http://www.ncbi.nlm.nih.gov/pubmed/1650347 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3323532 http://www.ncbi.nlm.nih.gov/pubmed/3323532 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 REBASE 980 http://rebase.neb.com/rebase/enz/980.html RefSeq NP_418770 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418770 RefSeq WP_000981388 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000981388 SMART SM00487 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00487 SMART SM00490 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00490 STRING 511145.b4350 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4350&targetmode=cogs STRING COG0610 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0610&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.17.1 http://www.tcdb.org/search/result.php?tc=3.A.17.1 UniProtKB T1RK_ECOLI http://www.uniprot.org/uniprot/T1RK_ECOLI UniProtKB-AC P08956 http://www.uniprot.org/uniprot/P08956 charge swissprot:T1RK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:T1RK_ECOLI eggNOG COG4096 http://eggnogapi.embl.de/nog_data/html/tree/COG4096 eggNOG ENOG4107SCJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107SCJ epestfind swissprot:T1RK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:T1RK_ECOLI garnier swissprot:T1RK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:T1RK_ECOLI helixturnhelix swissprot:T1RK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:T1RK_ECOLI hmoment swissprot:T1RK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:T1RK_ECOLI iep swissprot:T1RK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:T1RK_ECOLI inforesidue swissprot:T1RK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:T1RK_ECOLI octanol swissprot:T1RK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:T1RK_ECOLI pepcoil swissprot:T1RK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:T1RK_ECOLI pepdigest swissprot:T1RK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:T1RK_ECOLI pepinfo swissprot:T1RK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:T1RK_ECOLI pepnet swissprot:T1RK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:T1RK_ECOLI pepstats swissprot:T1RK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:T1RK_ECOLI pepwheel swissprot:T1RK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:T1RK_ECOLI pepwindow swissprot:T1RK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:T1RK_ECOLI sigcleave swissprot:T1RK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:T1RK_ECOLI ## Database ID URL or Descriptions # BioGrid 4259658 6 # EcoGene EG10321 fliC # FUNCTION FLIC_ECOLI Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. # GO_component GO:0005576 extracellular region; TAS:Reactome. # GO_component GO:0005886 plasma membrane; TAS:Reactome. # GO_component GO:0009420 bacterial-type flagellum filament; IEA:InterPro. # GO_function GO:0005198 structural molecule activity; IEA:InterPro. # GO_process GO:0002755 MyD88-dependent toll-like receptor signaling pathway; TAS:Reactome. # GO_process GO:0034146 toll-like receptor 5 signaling pathway; TAS:Reactome. # GO_process GO:0071973 bacterial-type flagellum-dependent cell motility; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005576 extracellular region # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0005198 structural molecule activity # GOslim_process GO:0002376 immune system process # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0048870 cell motility # Gene3D 1.20.1330.10 -; 2. # IntAct P04949 11 # InterPro IPR001029 Flagellin_D0/D1 # InterPro IPR001492 Flagellin # InterPro IPR014981 Flagellin_D3 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Pathway ko02020 Two-component system # KEGG_Pathway ko02040 Flagellar assembly # KEGG_Pathway ko04626 Plant-pathogen interaction # KEGG_Pathway ko05132 Salmonella infection # KEGG_Pathway ko05134 Legionellosis # Organism FLIC_ECOLI Escherichia coli (strain K12) # PATRIC 32119181 VBIEscCol129921_2005 # PIR A37249 FLEC # PRINTS PR00207 FLAGELLIN # Pfam PF00669 Flagellin_N # Pfam PF00700 Flagellin_C # Pfam PF08884 Flagellin_D3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # Reactome R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade # Reactome R-HSA-5602680 MyD88 deficiency (TLR5) # Reactome R-HSA-5603037 IRAK4 deficiency (TLR5) # Reactome R-HSA-975871 MyD88 cascade initiated on plasma membrane # RecName FLIC_ECOLI Flagellin # RefSeq NP_416433 NC_000913.3 # RefSeq WP_000079739 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial flagellin family. {ECO 0000305}. # SUBCELLULAR LOCATION FLIC_ECOLI Secreted. Bacterial flagellum. # eggNOG COG1344 LUCA # eggNOG ENOG4105I03 Bacteria BLAST swissprot:FLIC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLIC_ECOLI BioCyc ECOL316407:JW1908-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1908-MONOMER BioCyc EcoCyc:EG10321-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10321-MONOMER COG COG1344 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1344 DIP DIP-9649N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9649N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1998.1726 http://dx.doi.org/10.1006/jmbi.1998.1726 DOI 10.1007/BF00332229 http://dx.doi.org/10.1007/BF00332229 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01607 http://www.ebi.ac.uk/ena/data/view/J01607 EMBL M14358 http://www.ebi.ac.uk/ena/data/view/M14358 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X17440 http://www.ebi.ac.uk/ena/data/view/X17440 EchoBASE EB0317 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0317 EcoGene EG10321 http://www.ecogene.org/geneInfo.php?eg_id=EG10321 EnsemblBacteria AAC74990 http://www.ensemblgenomes.org/id/AAC74990 EnsemblBacteria AAC74990 http://www.ensemblgenomes.org/id/AAC74990 EnsemblBacteria BAA15751 http://www.ensemblgenomes.org/id/BAA15751 EnsemblBacteria BAA15751 http://www.ensemblgenomes.org/id/BAA15751 EnsemblBacteria BAA15751 http://www.ensemblgenomes.org/id/BAA15751 EnsemblBacteria b1923 http://www.ensemblgenomes.org/id/b1923 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005576 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0009420 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009420 GO_function GO:0005198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005198 GO_process GO:0002755 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002755 GO_process GO:0034146 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034146 GO_process GO:0071973 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071973 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005576 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0005198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005198 GOslim_process GO:0002376 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 Gene3D 1.20.1330.10 http://www.cathdb.info/version/latest/superfamily/1.20.1330.10 GeneID 949101 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949101 HOGENOM HOG000255144 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000255144&db=HOGENOM6 InParanoid P04949 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P04949 IntAct P04949 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P04949* InterPro IPR001029 http://www.ebi.ac.uk/interpro/entry/IPR001029 InterPro IPR001492 http://www.ebi.ac.uk/interpro/entry/IPR001492 InterPro IPR014981 http://www.ebi.ac.uk/interpro/entry/IPR014981 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW1908 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1908 KEGG_Gene eco:b1923 http://www.genome.jp/dbget-bin/www_bget?eco:b1923 KEGG_Orthology KO:K02406 http://www.genome.jp/dbget-bin/www_bget?KO:K02406 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 KEGG_Pathway ko02040 http://www.genome.jp/kegg-bin/show_pathway?ko02040 KEGG_Pathway ko04626 http://www.genome.jp/kegg-bin/show_pathway?ko04626 KEGG_Pathway ko05132 http://www.genome.jp/kegg-bin/show_pathway?ko05132 KEGG_Pathway ko05134 http://www.genome.jp/kegg-bin/show_pathway?ko05134 OMA FKTGEAD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FKTGEAD PRINTS PR00207 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00207 PSORT swissprot:FLIC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLIC_ECOLI PSORT-B swissprot:FLIC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLIC_ECOLI PSORT2 swissprot:FLIC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLIC_ECOLI Pfam PF00669 http://pfam.xfam.org/family/PF00669 Pfam PF00700 http://pfam.xfam.org/family/PF00700 Pfam PF08884 http://pfam.xfam.org/family/PF08884 Phobius swissprot:FLIC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLIC_ECOLI PhylomeDB P04949 http://phylomedb.org/?seqid=P04949 ProteinModelPortal P04949 http://www.proteinmodelportal.org/query/uniprot/P04949 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2659972 http://www.ncbi.nlm.nih.gov/pubmed/2659972 PubMed 3536885 http://www.ncbi.nlm.nih.gov/pubmed/3536885 PubMed 6305924 http://www.ncbi.nlm.nih.gov/pubmed/6305924 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 Reactome R-HSA-168176 http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-168176 Reactome R-HSA-5602680 http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5602680 Reactome R-HSA-5603037 http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-5603037 Reactome R-HSA-975871 http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-975871 RefSeq NP_416433 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416433 RefSeq WP_000079739 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000079739 SMR P04949 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P04949 STRING 511145.b1923 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1923&targetmode=cogs STRING COG1344 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1344&targetmode=cogs SWISS-2DPAGE P04949 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P04949 UniProtKB FLIC_ECOLI http://www.uniprot.org/uniprot/FLIC_ECOLI UniProtKB-AC P04949 http://www.uniprot.org/uniprot/P04949 charge swissprot:FLIC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLIC_ECOLI eggNOG COG1344 http://eggnogapi.embl.de/nog_data/html/tree/COG1344 eggNOG ENOG4105I03 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105I03 epestfind swissprot:FLIC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLIC_ECOLI garnier swissprot:FLIC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLIC_ECOLI helixturnhelix swissprot:FLIC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLIC_ECOLI hmoment swissprot:FLIC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLIC_ECOLI iep swissprot:FLIC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLIC_ECOLI inforesidue swissprot:FLIC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLIC_ECOLI octanol swissprot:FLIC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLIC_ECOLI pepcoil swissprot:FLIC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLIC_ECOLI pepdigest swissprot:FLIC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLIC_ECOLI pepinfo swissprot:FLIC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLIC_ECOLI pepnet swissprot:FLIC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLIC_ECOLI pepstats swissprot:FLIC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLIC_ECOLI pepwheel swissprot:FLIC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLIC_ECOLI pepwindow swissprot:FLIC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLIC_ECOLI sigcleave swissprot:FLIC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLIC_ECOLI ## Database ID URL or Descriptions # EcoGene EG40006 insF5 # FUNCTION INSF5_ECOLI Involved in the transposition of the insertion sequence IS3. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006310 DNA recombination; IEA:UniProtKB-KW. # GO_process GO:0015074 DNA integration; IEA:InterPro. # GO_process GO:0032196 transposition; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 3.30.420.10 -; 1. # InterPro IPR001584 Integrase_cat-core # InterPro IPR012337 RNaseH-like_dom # InterPro IPR025948 HTH-like_dom # Organism INSF5_ECOLI Escherichia coli (strain K12) # PIR C64756 TQECI3 # PROSITE PS50994 INTEGRASE # Pfam PF00665 rve # Pfam PF13276 HTH_21 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSF5_ECOLI Transposase InsF for insertion sequence IS3E # RefSeq NP_061381 NC_002483.1 # RefSeq NP_414833 NC_000913.3 # RefSeq NP_414906 NC_000913.3 # RefSeq NP_415073 NC_000913.3 # RefSeq NP_415545 NC_000913.3 # RefSeq NP_416593 NC_000913.3 # RefSeq WP_000878218 NZ_LN832404.1 # SIMILARITY Belongs to the transposase IS3/IS150/IS904 family. {ECO 0000305}. # SIMILARITY Contains 1 integrase catalytic domain. {ECO:0000255|PROSITE-ProRule PRU00457}. # SUPFAM SSF53098 SSF53098 # eggNOG COG2801 LUCA BLAST swissprot:INSF5_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSF5_ECOLI DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4713 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4713 EcoGene EG40006 http://www.ecogene.org/geneInfo.php?eg_id=EG40006 EnsemblBacteria AAC75150 http://www.ensemblgenomes.org/id/AAC75150 EnsemblBacteria AAC75150 http://www.ensemblgenomes.org/id/AAC75150 EnsemblBacteria BAA15941 http://www.ensemblgenomes.org/id/BAA15941 EnsemblBacteria BAA15941 http://www.ensemblgenomes.org/id/BAA15941 EnsemblBacteria BAA15941 http://www.ensemblgenomes.org/id/BAA15941 EnsemblBacteria b2089 http://www.ensemblgenomes.org/id/b2089 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0015074 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015074 GO_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 3.30.420.10 http://www.cathdb.info/version/latest/superfamily/3.30.420.10 GeneID 1263587 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263587 GeneID 944948 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944948 GeneID 945036 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945036 GeneID 945587 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945587 GeneID 946629 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946629 GeneID 947988 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947988 InParanoid P0CF83 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CF83 InterPro IPR001584 http://www.ebi.ac.uk/interpro/entry/IPR001584 InterPro IPR012337 http://www.ebi.ac.uk/interpro/entry/IPR012337 InterPro IPR025948 http://www.ebi.ac.uk/interpro/entry/IPR025948 KEGG_Gene ecj:JW2073 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2073 KEGG_Gene eco:b0299 http://www.genome.jp/dbget-bin/www_bget?eco:b0299 KEGG_Gene eco:b0372 http://www.genome.jp/dbget-bin/www_bget?eco:b0372 KEGG_Gene eco:b0541 http://www.genome.jp/dbget-bin/www_bget?eco:b0541 KEGG_Gene eco:b1026 http://www.genome.jp/dbget-bin/www_bget?eco:b1026 KEGG_Gene eco:b2089 http://www.genome.jp/dbget-bin/www_bget?eco:b2089 PROSITE PS50994 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50994 PSORT swissprot:INSF5_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSF5_ECOLI PSORT-B swissprot:INSF5_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSF5_ECOLI PSORT2 swissprot:INSF5_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSF5_ECOLI Pfam PF00665 http://pfam.xfam.org/family/PF00665 Pfam PF13276 http://pfam.xfam.org/family/PF13276 Phobius swissprot:INSF5_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSF5_ECOLI PhylomeDB P0CF83 http://phylomedb.org/?seqid=P0CF83 ProteinModelPortal P0CF83 http://www.proteinmodelportal.org/query/uniprot/P0CF83 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_061381 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061381 RefSeq NP_414833 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414833 RefSeq NP_414906 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414906 RefSeq NP_415073 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415073 RefSeq NP_415545 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415545 RefSeq NP_416593 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416593 RefSeq WP_000878218 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000878218 SMR P0CF83 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0CF83 STRING 511145.b2089 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2089&targetmode=cogs SUPFAM SSF53098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098 UniProtKB INSF5_ECOLI http://www.uniprot.org/uniprot/INSF5_ECOLI UniProtKB-AC P0CF83 http://www.uniprot.org/uniprot/P0CF83 charge swissprot:INSF5_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSF5_ECOLI eggNOG COG2801 http://eggnogapi.embl.de/nog_data/html/tree/COG2801 epestfind swissprot:INSF5_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSF5_ECOLI garnier swissprot:INSF5_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSF5_ECOLI helixturnhelix swissprot:INSF5_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSF5_ECOLI hmoment swissprot:INSF5_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSF5_ECOLI iep swissprot:INSF5_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSF5_ECOLI inforesidue swissprot:INSF5_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSF5_ECOLI octanol swissprot:INSF5_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSF5_ECOLI pepcoil swissprot:INSF5_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSF5_ECOLI pepdigest swissprot:INSF5_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSF5_ECOLI pepinfo swissprot:INSF5_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSF5_ECOLI pepnet swissprot:INSF5_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSF5_ECOLI pepstats swissprot:INSF5_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSF5_ECOLI pepwheel swissprot:INSF5_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSF5_ECOLI pepwindow swissprot:INSF5_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSF5_ECOLI sigcleave swissprot:INSF5_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSF5_ECOLI ## Database ID URL or Descriptions # BioGrid 4260360 12 # EcoGene EG14029 yobA # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0005507 copper ion binding; IEA:InterPro. # GO_process GO:0046688 response to copper ion; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # Gene3D 2.60.40.1220 -; 1. # IntAct P0AA57 5 # InterPro IPR007348 CopC_dom # InterPro IPR014755 Cu-Rt/internalin_Ig-like # InterPro IPR014756 Ig_E-set # Organism YOBA_ECOLI Escherichia coli (strain K12) # PATRIC 32119003 VBIEscCol129921_1919 # PIR A64946 A64946 # Pfam PF04234 CopC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YOBA_ECOLI Protein YobA # RefSeq NP_416355 NC_000913.3 # RefSeq WP_000168747 NZ_LN832404.1 # SIMILARITY Belongs to the CopC family. {ECO 0000305}. # SUBCELLULAR LOCATION YOBA_ECOLI Periplasm {ECO 0000250}. # SUPFAM SSF81296 SSF81296 # eggNOG COG2372 LUCA # eggNOG ENOG4105FXM Bacteria BLAST swissprot:YOBA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YOBA_ECOLI BioCyc ECOL316407:JW1830-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1830-MONOMER BioCyc EcoCyc:G7014-MONOMER http://biocyc.org/getid?id=EcoCyc:G7014-MONOMER COG COG2372 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2372 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1432-1327.2000.01296.x http://dx.doi.org/10.1046/j.1432-1327.2000.01296.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3783 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3783 EcoGene EG14029 http://www.ecogene.org/geneInfo.php?eg_id=EG14029 EnsemblBacteria AAC74911 http://www.ensemblgenomes.org/id/AAC74911 EnsemblBacteria AAC74911 http://www.ensemblgenomes.org/id/AAC74911 EnsemblBacteria BAE76545 http://www.ensemblgenomes.org/id/BAE76545 EnsemblBacteria BAE76545 http://www.ensemblgenomes.org/id/BAE76545 EnsemblBacteria BAE76545 http://www.ensemblgenomes.org/id/BAE76545 EnsemblBacteria b1841 http://www.ensemblgenomes.org/id/b1841 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0005507 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005507 GO_process GO:0046688 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046688 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 2.60.40.1220 http://www.cathdb.info/version/latest/superfamily/2.60.40.1220 GeneID 948315 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948315 HOGENOM HOG000127318 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000127318&db=HOGENOM6 InParanoid P0AA57 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AA57 IntAct P0AA57 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AA57* InterPro IPR007348 http://www.ebi.ac.uk/interpro/entry/IPR007348 InterPro IPR014755 http://www.ebi.ac.uk/interpro/entry/IPR014755 InterPro IPR014756 http://www.ebi.ac.uk/interpro/entry/IPR014756 KEGG_Gene ecj:JW1830 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1830 KEGG_Gene eco:b1841 http://www.genome.jp/dbget-bin/www_bget?eco:b1841 KEGG_Orthology KO:K07156 http://www.genome.jp/dbget-bin/www_bget?KO:K07156 OMA GHKTKGS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GHKTKGS PSORT swissprot:YOBA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YOBA_ECOLI PSORT-B swissprot:YOBA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YOBA_ECOLI PSORT2 swissprot:YOBA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YOBA_ECOLI Pfam PF04234 http://pfam.xfam.org/family/PF04234 Phobius swissprot:YOBA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YOBA_ECOLI ProteinModelPortal P0AA57 http://www.proteinmodelportal.org/query/uniprot/P0AA57 PubMed 10806384 http://www.ncbi.nlm.nih.gov/pubmed/10806384 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416355 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416355 RefSeq WP_000168747 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000168747 SMR P0AA57 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AA57 STRING 511145.b1841 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1841&targetmode=cogs STRING COG2372 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2372&targetmode=cogs SUPFAM SSF81296 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81296 UniProtKB YOBA_ECOLI http://www.uniprot.org/uniprot/YOBA_ECOLI UniProtKB-AC P0AA57 http://www.uniprot.org/uniprot/P0AA57 charge swissprot:YOBA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YOBA_ECOLI eggNOG COG2372 http://eggnogapi.embl.de/nog_data/html/tree/COG2372 eggNOG ENOG4105FXM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FXM epestfind swissprot:YOBA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YOBA_ECOLI garnier swissprot:YOBA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YOBA_ECOLI helixturnhelix swissprot:YOBA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YOBA_ECOLI hmoment swissprot:YOBA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YOBA_ECOLI iep swissprot:YOBA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YOBA_ECOLI inforesidue swissprot:YOBA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YOBA_ECOLI octanol swissprot:YOBA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YOBA_ECOLI pepcoil swissprot:YOBA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YOBA_ECOLI pepdigest swissprot:YOBA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YOBA_ECOLI pepinfo swissprot:YOBA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YOBA_ECOLI pepnet swissprot:YOBA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YOBA_ECOLI pepstats swissprot:YOBA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YOBA_ECOLI pepwheel swissprot:YOBA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YOBA_ECOLI pepwindow swissprot:YOBA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YOBA_ECOLI sigcleave swissprot:YOBA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YOBA_ECOLI ## Database ID URL or Descriptions # BioGrid 4263108 9 # EcoGene EG13180 ydbH # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GOslim_component GO:0005886 plasma membrane # IntAct P52645 17 # InterPro IPR021730 DctA-YdbH # Organism YDBH_ECOLI Escherichia coli (strain K12) # PATRIC 32118048 VBIEscCol129921_1444 # PIR H64888 H64888 # Pfam PF11739 DctA-YdbH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDBH_ECOLI Uncharacterized protein YdbH # RefSeq NP_415899 NC_000913.3 # RefSeq WP_000900941 NZ_LN832404.1 # eggNOG ENOG4107H52 Bacteria # eggNOG ENOG410XP3R LUCA BLAST swissprot:YDBH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDBH_ECOLI BioCyc ECOL316407:JW1376-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1376-MONOMER BioCyc EcoCyc:G6703-MONOMER http://biocyc.org/getid?id=EcoCyc:G6703-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1099/00221287-143-1-187 http://dx.doi.org/10.1099/00221287-143-1-187 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36928 http://www.ebi.ac.uk/ena/data/view/U36928 EchoBASE EB2972 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2972 EcoGene EG13180 http://www.ecogene.org/geneInfo.php?eg_id=EG13180 EnsemblBacteria AAC74463 http://www.ensemblgenomes.org/id/AAC74463 EnsemblBacteria AAC74463 http://www.ensemblgenomes.org/id/AAC74463 EnsemblBacteria BAA14991 http://www.ensemblgenomes.org/id/BAA14991 EnsemblBacteria BAA14991 http://www.ensemblgenomes.org/id/BAA14991 EnsemblBacteria BAA14991 http://www.ensemblgenomes.org/id/BAA14991 EnsemblBacteria b1381 http://www.ensemblgenomes.org/id/b1381 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 945949 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945949 HOGENOM HOG000120519 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120519&db=HOGENOM6 IntAct P52645 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P52645* InterPro IPR021730 http://www.ebi.ac.uk/interpro/entry/IPR021730 KEGG_Gene ecj:JW1376 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1376 KEGG_Gene eco:b1381 http://www.genome.jp/dbget-bin/www_bget?eco:b1381 OMA GGHWVVK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GGHWVVK PSORT swissprot:YDBH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDBH_ECOLI PSORT-B swissprot:YDBH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDBH_ECOLI PSORT2 swissprot:YDBH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDBH_ECOLI Pfam PF11739 http://pfam.xfam.org/family/PF11739 Phobius swissprot:YDBH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDBH_ECOLI ProteinModelPortal P52645 http://www.proteinmodelportal.org/query/uniprot/P52645 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9025293 http://www.ncbi.nlm.nih.gov/pubmed/9025293 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415899 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415899 RefSeq WP_000900941 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000900941 SMR P52645 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P52645 STRING 511145.b1381 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1381&targetmode=cogs UniProtKB YDBH_ECOLI http://www.uniprot.org/uniprot/YDBH_ECOLI UniProtKB-AC P52645 http://www.uniprot.org/uniprot/P52645 charge swissprot:YDBH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDBH_ECOLI eggNOG ENOG4107H52 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107H52 eggNOG ENOG410XP3R http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XP3R epestfind swissprot:YDBH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDBH_ECOLI garnier swissprot:YDBH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDBH_ECOLI helixturnhelix swissprot:YDBH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDBH_ECOLI hmoment swissprot:YDBH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDBH_ECOLI iep swissprot:YDBH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDBH_ECOLI inforesidue swissprot:YDBH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDBH_ECOLI octanol swissprot:YDBH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDBH_ECOLI pepcoil swissprot:YDBH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDBH_ECOLI pepdigest swissprot:YDBH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDBH_ECOLI pepinfo swissprot:YDBH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDBH_ECOLI pepnet swissprot:YDBH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDBH_ECOLI pepstats swissprot:YDBH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDBH_ECOLI pepwheel swissprot:YDBH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDBH_ECOLI pepwindow swissprot:YDBH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDBH_ECOLI sigcleave swissprot:YDBH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDBH_ECOLI ## Database ID URL or Descriptions # AltName ALPA_ECOLI Prophage CP4-57 regulatory protein AlpA # BioGrid 4260621 8 # EcoGene EG12112 alpA # FUNCTION ALPA_ECOLI Positive regulator of the expression of the slpA gene. # GO_component GO:0019038 provirus; ISS:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0044010 single-species biofilm formation; IGI:EcoCyc. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # IntAct P33997 3 # InterPro IPR010260 Phage_AlpA # KEGG_Brite ko03000 Transcription factors # Organism ALPA_ECOLI Escherichia coli (strain K12) # PIR B65041 B65041 # Pfam PF05930 Phage_AlpA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Prophage regulatory protein AlpA {ECO 0000305} # RefSeq NP_417113 NC_000913.3 # RefSeq WP_001065343 NZ_LN832404.1 # eggNOG COG3311 LUCA # eggNOG ENOG410679B Bacteria BLAST swissprot:ALPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ALPA_ECOLI BioCyc ECOL316407:JW2604-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2604-MONOMER BioCyc EcoCyc:PD02850 http://biocyc.org/getid?id=EcoCyc:PD02850 COG COG3311 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3311 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U03737 http://www.ebi.ac.uk/ena/data/view/U03737 EMBL U36840 http://www.ebi.ac.uk/ena/data/view/U36840 EchoBASE EB2035 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2035 EcoGene EG12112 http://www.ecogene.org/geneInfo.php?eg_id=EG12112 EnsemblBacteria AAC75672 http://www.ensemblgenomes.org/id/AAC75672 EnsemblBacteria AAC75672 http://www.ensemblgenomes.org/id/AAC75672 EnsemblBacteria BAE76759 http://www.ensemblgenomes.org/id/BAE76759 EnsemblBacteria BAE76759 http://www.ensemblgenomes.org/id/BAE76759 EnsemblBacteria BAE76759 http://www.ensemblgenomes.org/id/BAE76759 EnsemblBacteria b2624 http://www.ensemblgenomes.org/id/b2624 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0019038 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019038 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0044010 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044010 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 946758 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946758 HOGENOM HOG000263166 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000263166&db=HOGENOM6 InParanoid P33997 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33997 IntAct P33997 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33997* InterPro IPR010260 http://www.ebi.ac.uk/interpro/entry/IPR010260 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW2604 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2604 KEGG_Gene eco:b2624 http://www.genome.jp/dbget-bin/www_bget?eco:b2624 KEGG_Orthology KO:K07733 http://www.genome.jp/dbget-bin/www_bget?KO:K07733 OMA GWLESEI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GWLESEI PSORT swissprot:ALPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ALPA_ECOLI PSORT-B swissprot:ALPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ALPA_ECOLI PSORT2 swissprot:ALPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ALPA_ECOLI Pfam PF05930 http://pfam.xfam.org/family/PF05930 Phobius swissprot:ALPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ALPA_ECOLI ProteinModelPortal P33997 http://www.proteinmodelportal.org/query/uniprot/P33997 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7511582 http://www.ncbi.nlm.nih.gov/pubmed/7511582 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417113 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417113 RefSeq WP_001065343 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001065343 STRING 511145.b2624 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2624&targetmode=cogs STRING COG3311 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3311&targetmode=cogs UniProtKB ALPA_ECOLI http://www.uniprot.org/uniprot/ALPA_ECOLI UniProtKB-AC P33997 http://www.uniprot.org/uniprot/P33997 charge swissprot:ALPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ALPA_ECOLI eggNOG COG3311 http://eggnogapi.embl.de/nog_data/html/tree/COG3311 eggNOG ENOG410679B http://eggnogapi.embl.de/nog_data/html/tree/ENOG410679B epestfind swissprot:ALPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ALPA_ECOLI garnier swissprot:ALPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ALPA_ECOLI helixturnhelix swissprot:ALPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ALPA_ECOLI hmoment swissprot:ALPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ALPA_ECOLI iep swissprot:ALPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ALPA_ECOLI inforesidue swissprot:ALPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ALPA_ECOLI octanol swissprot:ALPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ALPA_ECOLI pepcoil swissprot:ALPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ALPA_ECOLI pepdigest swissprot:ALPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ALPA_ECOLI pepinfo swissprot:ALPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ALPA_ECOLI pepnet swissprot:ALPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ALPA_ECOLI pepstats swissprot:ALPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ALPA_ECOLI pepwheel swissprot:ALPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ALPA_ECOLI pepwindow swissprot:ALPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ALPA_ECOLI sigcleave swissprot:ALPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ALPA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260830 547 # EcoGene EG13654 corC # FUNCTION CORC_ECOLI Plays a role in the transport of magnesium and cobalt ions. {ECO 0000250}. # GO_component GO:0005886 plasma membrane; IBA:GO_Central. # GO_function GO:0016614 oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro. # GO_function GO:0050660 flavin adenine dinucleotide binding; IEA:InterPro. # GO_process GO:0006810 transport; IEA:UniProtKB-KW. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # Gene3D 3.30.465.10 -; 1. # IntAct P0AE78 8 # InterPro IPR000644 CBS_dom # InterPro IPR005170 Transptr-assoc_dom # InterPro IPR016166 FAD-bd_2 # InterPro IPR016169 CO_DH_flavot_FAD-bd_sub2 # KEGG_Brite ko02000 Transporters # Organism CORC_ECOLI Escherichia coli (strain K12) # PATRIC 32116505 VBIEscCol129921_0692 # PDB 4HG0 X-ray; 3.10 A; A=1-292 # PIR H64800 H64800 # PROSITE PS51371 CBS; 2 # Pfam PF00571 CBS; 2 # Pfam PF03471 CorC_HlyC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CORC_ECOLI Magnesium and cobalt efflux protein CorC # RefSeq NP_415191 NC_000913.3 # RefSeq WP_001278605 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0053 family. {ECO 0000305}. # SIMILARITY Contains 2 CBS domains. {ECO:0000255|PROSITE- ProRule PRU00703}. # SMART SM00116 CBS; 2 # SMART SM01091 CorC_HlyC # SUPFAM SSF56176 SSF56176 # eggNOG COG4535 LUCA # eggNOG ENOG4108JU5 Bacteria BLAST swissprot:CORC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CORC_ECOLI BioCyc ECOL316407:JW0655-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0655-MONOMER BioCyc EcoCyc:G6361-MONOMER http://biocyc.org/getid?id=EcoCyc:G6361-MONOMER COG COG4535 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4535 DIP DIP-35960N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35960N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB3418 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3418 EcoGene EG13654 http://www.ecogene.org/geneInfo.php?eg_id=EG13654 EnsemblBacteria AAC73759 http://www.ensemblgenomes.org/id/AAC73759 EnsemblBacteria AAC73759 http://www.ensemblgenomes.org/id/AAC73759 EnsemblBacteria BAA35309 http://www.ensemblgenomes.org/id/BAA35309 EnsemblBacteria BAA35309 http://www.ensemblgenomes.org/id/BAA35309 EnsemblBacteria BAA35309 http://www.ensemblgenomes.org/id/BAA35309 EnsemblBacteria b0658 http://www.ensemblgenomes.org/id/b0658 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0016614 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016614 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.30.465.10 http://www.cathdb.info/version/latest/superfamily/3.30.465.10 GeneID 946417 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946417 HOGENOM HOG000062294 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000062294&db=HOGENOM6 InParanoid P0AE78 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AE78 IntAct P0AE78 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AE78* InterPro IPR000644 http://www.ebi.ac.uk/interpro/entry/IPR000644 InterPro IPR005170 http://www.ebi.ac.uk/interpro/entry/IPR005170 InterPro IPR016166 http://www.ebi.ac.uk/interpro/entry/IPR016166 InterPro IPR016169 http://www.ebi.ac.uk/interpro/entry/IPR016169 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0655 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0655 KEGG_Gene eco:b0658 http://www.genome.jp/dbget-bin/www_bget?eco:b0658 KEGG_Orthology KO:K06189 http://www.genome.jp/dbget-bin/www_bget?KO:K06189 OMA INIADNP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=INIADNP PDB 4HG0 http://www.ebi.ac.uk/pdbe-srv/view/entry/4HG0 PDBsum 4HG0 http://www.ebi.ac.uk/pdbsum/4HG0 PROSITE PS51371 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51371 PSORT swissprot:CORC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CORC_ECOLI PSORT-B swissprot:CORC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CORC_ECOLI PSORT2 swissprot:CORC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CORC_ECOLI Pfam PF00571 http://pfam.xfam.org/family/PF00571 Pfam PF03471 http://pfam.xfam.org/family/PF03471 Phobius swissprot:CORC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CORC_ECOLI PhylomeDB P0AE78 http://phylomedb.org/?seqid=P0AE78 ProteinModelPortal P0AE78 http://www.proteinmodelportal.org/query/uniprot/P0AE78 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415191 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415191 RefSeq WP_001278605 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001278605 SMART SM00116 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00116 SMART SM01091 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01091 SMR P0AE78 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AE78 STRING 511145.b0658 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0658&targetmode=cogs STRING COG4535 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4535&targetmode=cogs SUPFAM SSF56176 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56176 UniProtKB CORC_ECOLI http://www.uniprot.org/uniprot/CORC_ECOLI UniProtKB-AC P0AE78 http://www.uniprot.org/uniprot/P0AE78 charge swissprot:CORC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CORC_ECOLI eggNOG COG4535 http://eggnogapi.embl.de/nog_data/html/tree/COG4535 eggNOG ENOG4108JU5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108JU5 epestfind swissprot:CORC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CORC_ECOLI garnier swissprot:CORC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CORC_ECOLI helixturnhelix swissprot:CORC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CORC_ECOLI hmoment swissprot:CORC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CORC_ECOLI iep swissprot:CORC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CORC_ECOLI inforesidue swissprot:CORC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CORC_ECOLI octanol swissprot:CORC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CORC_ECOLI pepcoil swissprot:CORC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CORC_ECOLI pepdigest swissprot:CORC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CORC_ECOLI pepinfo swissprot:CORC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CORC_ECOLI pepnet swissprot:CORC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CORC_ECOLI pepstats swissprot:CORC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CORC_ECOLI pepwheel swissprot:CORC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CORC_ECOLI pepwindow swissprot:CORC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CORC_ECOLI sigcleave swissprot:CORC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CORC_ECOLI ## Database ID URL or Descriptions # BRENDA 3.1.1.58 2026 # BioGrid 4260050 16 # DISRUPTION PHENOTYPE PGAB_ECOLI Deletion of pgaB does not prevent PGA synthesis but does block its export and biofilm formation. The synthesized PGA is retained in the periplasm and accumulates at the cell poles. {ECO 0000269|PubMed 15090514, ECO 0000269|PubMed 18359807}. # DOMAIN PGAB_ECOLI Contains a N-terminal polysaccharide deacetylase domain, and a C-terminal domain required for PGA N-deacetylation that may be involved in binding to unmodified poly-beta-1,6-GlcNAc and thereby assists catalysis by the deacetylase domain. {ECO 0000269|PubMed 18359807}. # EcoGene EG13864 pgaB # FUNCTION PGAB_ECOLI Catalyzes the N-deacetylation of poly-beta-1,6-N-acetyl- D-glucosamine (PGA), a biofilm adhesin polysaccharide. N- deacetylation promotes PGA export through the PgaA porin. {ECO 0000269|PubMed 15090514, ECO 0000269|PubMed 18359807}. # GO_component GO:0009279 cell outer membrane; IEA:UniProtKB-SubCell. # GO_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; IDA:EcoCyc. # GO_process GO:0005975 carbohydrate metabolic process; IEA:InterPro. # GO_process GO:0044010 single-species biofilm formation; IMP:EcoCyc. # GO_process GO:0098732 macromolecule deacylation; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0008150 biological_process # Gene3D 3.20.20.370 -; 1. # InterPro IPR002509 NODB_dom # InterPro IPR011330 Glyco_hydro/deAcase_b/a-brl # InterPro IPR023854 PGA_deacetylase_PgaB # InterPro IPR032772 PGA_deacetylase_PgaB_C # KEGG_Brite ko01000 Enzymes # Organism PGAB_ECOLI Escherichia coli (strain K12) # PATRIC 32117279 VBIEscCol129921_1063 # PDB 3VUS X-ray; 1.65 A; A/B=42-309 # PDB 4F9D X-ray; 1.90 A; A/B=42-655 # PDB 4F9J X-ray; 2.10 A; A/B=42-655 # PDB 4P7L X-ray; 1.80 A; A=310-672 # PDB 4P7N X-ray; 1.89 A; A=310-672 # PDB 4P7O X-ray; 1.48 A; A/B=310-672 # PDB 4P7Q X-ray; 1.65 A; A=310-672 # PDB 4P7R X-ray; 1.80 A; A=310-672 # PIR E64844 E64844 # PROSITE PS51257 PROKAR_LIPOPROTEIN # PROSITE PS51677 NODB # Pfam PF01522 Polysacc_deac_1 # Pfam PF14883 GHL13 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PGAB_ECOLI Poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase # RefSeq NP_415542 NC_000913.3 # RefSeq WP_000945561 NZ_LN832404.1 # SIMILARITY Belongs to the polysaccharide deacetylase family. {ECO 0000305}. # SIMILARITY Contains 1 NodB homology domain. {ECO:0000255|PROSITE- ProRule PRU01014}. # SUBCELLULAR LOCATION PGAB_ECOLI Cell outer membrane {ECO 0000305|PubMed 18359807}; Lipid-anchor {ECO 0000305|PubMed 18359807}; Periplasmic side {ECO 0000305|PubMed 18359807}. # SUPFAM SSF88713 SSF88713; 2 # TIGRFAMs TIGR03938 deacetyl_PgaB # eggNOG COG0726 LUCA # eggNOG ENOG4107BJW Bacteria BLAST swissprot:PGAB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PGAB_ECOLI BioCyc ECOL316407:JW5142-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5142-MONOMER BioCyc EcoCyc:G6530-MONOMER http://biocyc.org/getid?id=EcoCyc:G6530-MONOMER BioCyc MetaCyc:G6530-MONOMER http://biocyc.org/getid?id=MetaCyc:G6530-MONOMER COG COG0726 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0726 DIP DIP-11513N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11513N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01920-07 http://dx.doi.org/10.1128/JB.01920-07 DOI 10.1128/JB.186.9.2724-2734.2004 http://dx.doi.org/10.1128/JB.186.9.2724-2734.2004 EC_number EC:3.5.1.- http://www.genome.jp/dbget-bin/www_bget?EC:3.5.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.5.1.- http://enzyme.expasy.org/EC/3.5.1.- EchoBASE EB3624 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3624 EcoGene EG13864 http://www.ecogene.org/geneInfo.php?eg_id=EG13864 EnsemblBacteria AAC74108 http://www.ensemblgenomes.org/id/AAC74108 EnsemblBacteria AAC74108 http://www.ensemblgenomes.org/id/AAC74108 EnsemblBacteria BAA35805 http://www.ensemblgenomes.org/id/BAA35805 EnsemblBacteria BAA35805 http://www.ensemblgenomes.org/id/BAA35805 EnsemblBacteria BAA35805 http://www.ensemblgenomes.org/id/BAA35805 EnsemblBacteria b1023 http://www.ensemblgenomes.org/id/b1023 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GO_process GO:0044010 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044010 GO_process GO:0098732 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098732 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.20.20.370 http://www.cathdb.info/version/latest/superfamily/3.20.20.370 GeneID 945604 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945604 HOGENOM HOG000170240 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000170240&db=HOGENOM6 IntEnz 3.5.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.1 InterPro IPR002509 http://www.ebi.ac.uk/interpro/entry/IPR002509 InterPro IPR011330 http://www.ebi.ac.uk/interpro/entry/IPR011330 InterPro IPR023854 http://www.ebi.ac.uk/interpro/entry/IPR023854 InterPro IPR032772 http://www.ebi.ac.uk/interpro/entry/IPR032772 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5142 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5142 KEGG_Gene eco:b1023 http://www.genome.jp/dbget-bin/www_bget?eco:b1023 KEGG_Orthology KO:K11931 http://www.genome.jp/dbget-bin/www_bget?KO:K11931 OMA KVYAWMP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KVYAWMP PDB 3VUS http://www.ebi.ac.uk/pdbe-srv/view/entry/3VUS PDB 4F9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4F9D PDB 4F9J http://www.ebi.ac.uk/pdbe-srv/view/entry/4F9J PDB 4P7L http://www.ebi.ac.uk/pdbe-srv/view/entry/4P7L PDB 4P7N http://www.ebi.ac.uk/pdbe-srv/view/entry/4P7N PDB 4P7O http://www.ebi.ac.uk/pdbe-srv/view/entry/4P7O PDB 4P7Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4P7Q PDB 4P7R http://www.ebi.ac.uk/pdbe-srv/view/entry/4P7R PDBsum 3VUS http://www.ebi.ac.uk/pdbsum/3VUS PDBsum 4F9D http://www.ebi.ac.uk/pdbsum/4F9D PDBsum 4F9J http://www.ebi.ac.uk/pdbsum/4F9J PDBsum 4P7L http://www.ebi.ac.uk/pdbsum/4P7L PDBsum 4P7N http://www.ebi.ac.uk/pdbsum/4P7N PDBsum 4P7O http://www.ebi.ac.uk/pdbsum/4P7O PDBsum 4P7Q http://www.ebi.ac.uk/pdbsum/4P7Q PDBsum 4P7R http://www.ebi.ac.uk/pdbsum/4P7R PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PROSITE PS51677 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51677 PSORT swissprot:PGAB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PGAB_ECOLI PSORT-B swissprot:PGAB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PGAB_ECOLI PSORT2 swissprot:PGAB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PGAB_ECOLI Pfam PF01522 http://pfam.xfam.org/family/PF01522 Pfam PF14883 http://pfam.xfam.org/family/PF14883 Phobius swissprot:PGAB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PGAB_ECOLI ProteinModelPortal P75906 http://www.proteinmodelportal.org/query/uniprot/P75906 PubMed 15090514 http://www.ncbi.nlm.nih.gov/pubmed/15090514 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18359807 http://www.ncbi.nlm.nih.gov/pubmed/18359807 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415542 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415542 RefSeq WP_000945561 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000945561 SMR P75906 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75906 STRING 511145.b1023 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1023&targetmode=cogs STRING COG0726 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0726&targetmode=cogs SUPFAM SSF88713 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF88713 TIGRFAMs TIGR03938 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03938 UniProtKB PGAB_ECOLI http://www.uniprot.org/uniprot/PGAB_ECOLI UniProtKB-AC P75906 http://www.uniprot.org/uniprot/P75906 charge swissprot:PGAB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PGAB_ECOLI eggNOG COG0726 http://eggnogapi.embl.de/nog_data/html/tree/COG0726 eggNOG ENOG4107BJW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107BJW epestfind swissprot:PGAB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PGAB_ECOLI garnier swissprot:PGAB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PGAB_ECOLI helixturnhelix swissprot:PGAB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PGAB_ECOLI hmoment swissprot:PGAB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PGAB_ECOLI iep swissprot:PGAB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PGAB_ECOLI inforesidue swissprot:PGAB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PGAB_ECOLI octanol swissprot:PGAB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PGAB_ECOLI pepcoil swissprot:PGAB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PGAB_ECOLI pepdigest swissprot:PGAB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PGAB_ECOLI pepinfo swissprot:PGAB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PGAB_ECOLI pepnet swissprot:PGAB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PGAB_ECOLI pepstats swissprot:PGAB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PGAB_ECOLI pepwheel swissprot:PGAB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PGAB_ECOLI pepwindow swissprot:PGAB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PGAB_ECOLI sigcleave swissprot:PGAB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PGAB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260525 11 # EcoGene EG10072 argT # FUNCTION ARGT_ECOLI Part of an ABC transporter involved in lysine, arginine and ornithine transport. Stimulates ATPase activity of HisP (By similarity). {ECO 0000250}. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IEA:InterPro. # GO_function GO:0005215 transporter activity; IEA:InterPro. # GO_process GO:0006865 amino acid transport; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006810 transport # InterPro IPR001638 Solute-binding_3/MltF_N # InterPro IPR005768 Lys_Arg_Orn-bd # InterPro IPR018313 SBP_3_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00225 Lysine/arginine/ornithine transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism ARGT_ECOLI Escherichia coli (strain K12) # PATRIC 32119991 VBIEscCol129921_2405 # PIR D65003 JKECT # PROSITE PS01039 SBP_BACTERIAL_3 # Pfam PF00497 SBP_bac_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ARGT_ECOLI Lysine/arginine/ornithine-binding periplasmic protein # RefSeq NP_416813 NC_000913.3 # RefSeq WP_000748271 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial solute-binding protein 3 family. {ECO 0000305}. # SMART SM00062 PBPb # SUBCELLULAR LOCATION ARGT_ECOLI Periplasm. # SUBUNIT The complex is composed of two ATP-binding proteins (HisP), two transmembrane proteins (HisM and HisQ) and a solute- binding protein (ArgT). {ECO 0000250}. # TCDB 3.A.1.3 the atp-binding cassette (abc) superfamily # TCDB 3.A.1.3.29 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR01096 3A0103s03R # eggNOG COG0834 LUCA # eggNOG ENOG4105E89 Bacteria BLAST swissprot:ARGT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARGT_ECOLI BioCyc ECOL316407:JW2307-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2307-MONOMER BioCyc EcoCyc:ARGT-MONOMER http://biocyc.org/getid?id=EcoCyc:ARGT-MONOMER COG COG0834 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0834 DIP DIP-9148N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9148N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M68935 http://www.ebi.ac.uk/ena/data/view/M68935 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U47027 http://www.ebi.ac.uk/ena/data/view/U47027 EchoBASE EB0070 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0070 EcoGene EG10072 http://www.ecogene.org/geneInfo.php?eg_id=EG10072 EnsemblBacteria AAC75370 http://www.ensemblgenomes.org/id/AAC75370 EnsemblBacteria AAC75370 http://www.ensemblgenomes.org/id/AAC75370 EnsemblBacteria BAA16156 http://www.ensemblgenomes.org/id/BAA16156 EnsemblBacteria BAA16156 http://www.ensemblgenomes.org/id/BAA16156 EnsemblBacteria BAA16156 http://www.ensemblgenomes.org/id/BAA16156 EnsemblBacteria b2310 http://www.ensemblgenomes.org/id/b2310 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_process GO:0006865 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 949030 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949030 HOGENOM HOG000031896 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000031896&db=HOGENOM6 InParanoid P09551 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P09551 InterPro IPR001638 http://www.ebi.ac.uk/interpro/entry/IPR001638 InterPro IPR005768 http://www.ebi.ac.uk/interpro/entry/IPR005768 InterPro IPR018313 http://www.ebi.ac.uk/interpro/entry/IPR018313 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2307 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2307 KEGG_Gene eco:b2310 http://www.genome.jp/dbget-bin/www_bget?eco:b2310 KEGG_Orthology KO:K10013 http://www.genome.jp/dbget-bin/www_bget?KO:K10013 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA NWRSKGV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NWRSKGV PROSITE PS01039 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01039 PSORT swissprot:ARGT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARGT_ECOLI PSORT-B swissprot:ARGT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARGT_ECOLI PSORT2 swissprot:ARGT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARGT_ECOLI Pfam PF00497 http://pfam.xfam.org/family/PF00497 Phobius swissprot:ARGT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARGT_ECOLI PhylomeDB P09551 http://phylomedb.org/?seqid=P09551 ProteinModelPortal P09551 http://www.proteinmodelportal.org/query/uniprot/P09551 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3040734 http://www.ncbi.nlm.nih.gov/pubmed/3040734 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_416813 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416813 RefSeq WP_000748271 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000748271 SMART SM00062 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00062 SMR P09551 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P09551 STRING 511145.b2310 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2310&targetmode=cogs STRING COG0834 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0834&targetmode=cogs SWISS-2DPAGE P09551 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P09551 TCDB 3.A.1.3 http://www.tcdb.org/search/result.php?tc=3.A.1.3 TCDB 3.A.1.3.29 http://www.tcdb.org/search/result.php?tc=3.A.1.3.29 TIGRFAMs TIGR01096 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01096 UniProtKB ARGT_ECOLI http://www.uniprot.org/uniprot/ARGT_ECOLI UniProtKB-AC P09551 http://www.uniprot.org/uniprot/P09551 charge swissprot:ARGT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARGT_ECOLI eggNOG COG0834 http://eggnogapi.embl.de/nog_data/html/tree/COG0834 eggNOG ENOG4105E89 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E89 epestfind swissprot:ARGT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARGT_ECOLI garnier swissprot:ARGT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARGT_ECOLI helixturnhelix swissprot:ARGT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARGT_ECOLI hmoment swissprot:ARGT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARGT_ECOLI iep swissprot:ARGT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARGT_ECOLI inforesidue swissprot:ARGT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARGT_ECOLI octanol swissprot:ARGT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARGT_ECOLI pepcoil swissprot:ARGT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARGT_ECOLI pepdigest swissprot:ARGT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARGT_ECOLI pepinfo swissprot:ARGT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARGT_ECOLI pepnet swissprot:ARGT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARGT_ECOLI pepstats swissprot:ARGT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARGT_ECOLI pepwheel swissprot:ARGT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARGT_ECOLI pepwindow swissprot:ARGT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARGT_ECOLI sigcleave swissprot:ARGT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARGT_ECOLI ## Database ID URL or Descriptions # AltName CAS6_ECOLI CasE endoRNase # AltName CAS6_ECOLI crRNA endonuclease # BioGrid 4261580 317 # COFACTOR Note=Does not require a metal cofactor. {ECO:0000269|PubMed 18703739}; # DISRUPTION PHENOTYPE CAS6_ECOLI Loss of resistance to bacteriophage lambda infection, loss of plasmid silencing. Decreased levels of crRNA, increased levels of pre-crRNA, prevents pre-crRNA cleavage. {ECO 0000269|PubMed 18703739, ECO 0000269|PubMed 21255106, ECO 0000269|PubMed 21460843}. # EcoGene EG13115 casE # FUNCTION CAS6_ECOLI A component of Cascade, which participates in CRISPR interference, the third stage of CRISPR immunity. Cascade binds both crRNA and in a sequence-specific manner negatively supercoiled dsDNA target. This leads to the formation of an R-loop in which the crRNA binds the target DNA, displacing the noncomplementary strand. Cas3 is recruited to Cascade, nicks target DNA and then unwinds and cleaves the target, leading to DNA degradation and invader neutralization. # FUNCTION CAS6_ECOLI CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). # FUNCTION CAS6_ECOLI CasE is required to process the pre-crRNA into single repeat-spacer units, with an 8-nt 5'-repeat DNA tag that may help other proteins recognize the crRNA. This subunit alone will cleave pre-crRNA, as will CasCDE or CasCE; cleavage does not require divalent metals or ATP. CasCDE alone is also able to form R-loops. Partially inhibits the cleavage of Holliday junctions by YgbT (Cas1). Yields a 5'-hydroxy group and a 2',3'-cyclic phosphate terminus. # GO_component GO:0043234 protein complex; IDA:EcoCyc. # GO_function GO:0003723 RNA binding; IDA:EcoCyc. # GO_function GO:0004521 endoribonuclease activity; IDA:EcoCyc. # GO_process GO:0006396 RNA processing; IMP:EcoCyc. # GO_process GO:0051607 defense response to virus; IMP:EcoCyc. # GO_process GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic; IDA:EcoCyc. # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0004518 nuclease activity # GOslim_process GO:0002376 immune system process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044403 symbiosis, encompassing mutualism through parasitism # INDUCTION CAS6_ECOLI Repressed by H-NS, activated by LeuO. Activated by the BaeSR two-component regulatory system, possibly due to envelope stress. Part of the casABCDE-ygbT-ygbF operon. {ECO 0000269|PubMed 19429622, ECO 0000269|PubMed 20132443, ECO 0000269|PubMed 21255106}. # IntAct Q46897 2 # InterPro IPR010179 CRISPR-assoc_prot_Cse3 # MASS SPECTROMETRY Mass=22364.7; Mass_error=1.1; Method=Unknown; Range=2-199; Evidence={ECO:0000269|PubMed 21460843}; # Organism CAS6_ECOLI Escherichia coli (strain K12) # PATRIC 32120922 VBIEscCol129921_2853 # PDB 4DZD X-ray; 2.00 A; A=1-199 # PDB 4QYZ X-ray; 3.03 A; K=1-199 # PDB 4TVX X-ray; 3.24 A; A/M=1-199 # PDB 4U7U X-ray; 3.00 A; D/P=1-199 # PDB 5CD4 X-ray; 3.20 A; A/M=1-199 # PDB 5H9E X-ray; 3.21 A; K=1-199 # PDB 5H9F X-ray; 2.45 A; K=1-199 # PIR H65056 H65056 # Pfam PF08798 CRISPR_assoc # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CAS6_ECOLI CRISPR system Cascade subunit CasE # RefSeq NP_417236 NC_000913.3 # RefSeq WP_000281400 NZ_LN832404.1 # SIMILARITY Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family. Subtype I-E/Ecoli subfamily. {ECO 0000305}. # SMART SM01101 CRISPR_assoc # SUBUNIT CAS6_ECOLI Part of the Cascade ribonucleoprotein complex, with stoichiometry CasA(1),CasB(2),CasC(6),CasD(1),CasE(1)-crRNA(1). Interacts directly with crRNA, CasA, CasB and CasC. Stable subcomplexes of CasBCDE-crRNA and CasCDE-crRNA also form, both of which are able to bind target dsDNA, and CasCDE is able to form R- loops. CasCDE and CasCE complexes have endonuclease activity. Interacts with YgbT (Cas1). Binding of target ssRNA or dsDNA causes a conformational change in the Cascade complex. {ECO 0000269|PubMed 18703739, ECO 0000269|PubMed 21219465, ECO 0000269|PubMed 21255106, ECO 0000269|PubMed 21460843, ECO 0000269|PubMed 21699496, ECO 0000269|PubMed 21938068, ECO 0000269|PubMed 22521689}. # TIGRFAMs TIGR01907 casE_Cse3 # eggNOG ENOG4108Y7V Bacteria # eggNOG ENOG410ZWC5 LUCA BLAST swissprot:CAS6_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CAS6_ECOLI BioCyc ECOL316407:JW2726-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2726-MONOMER BioCyc EcoCyc:G7426-MONOMER http://biocyc.org/getid?id=EcoCyc:G7426-MONOMER BioCyc MetaCyc:G7426-MONOMER http://biocyc.org/getid?id=MetaCyc:G7426-MONOMER DIP DIP-12124N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12124N DOI 10.1016/j.molcel.2012.03.018 http://dx.doi.org/10.1016/j.molcel.2012.03.018 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature10402 http://dx.doi.org/10.1038/nature10402 DOI 10.1038/nsmb.2019 http://dx.doi.org/10.1038/nsmb.2019 DOI 10.1042/BJ20110901 http://dx.doi.org/10.1042/BJ20110901 DOI 10.1111/j.1365-2958.2010.07073.x http://dx.doi.org/10.1111/j.1365-2958.2010.07073.x DOI 10.1111/j.1365-2958.2010.07465.x http://dx.doi.org/10.1111/j.1365-2958.2010.07465.x DOI 10.1111/j.1365-2958.2010.07482.x http://dx.doi.org/10.1111/j.1365-2958.2010.07482.x DOI 10.1126/science.1159689 http://dx.doi.org/10.1126/science.1159689 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00108-09 http://dx.doi.org/10.1128/JB.00108-09 EC_number EC:3.1.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 ENZYME 3.1.-.- http://enzyme.expasy.org/EC/3.1.-.- EchoBASE EB2916 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2916 EcoGene EG13115 http://www.ecogene.org/geneInfo.php?eg_id=EG13115 EnsemblBacteria AAC75798 http://www.ensemblgenomes.org/id/AAC75798 EnsemblBacteria AAC75798 http://www.ensemblgenomes.org/id/AAC75798 EnsemblBacteria BAE76833 http://www.ensemblgenomes.org/id/BAE76833 EnsemblBacteria BAE76833 http://www.ensemblgenomes.org/id/BAE76833 EnsemblBacteria BAE76833 http://www.ensemblgenomes.org/id/BAE76833 EnsemblBacteria b2756 http://www.ensemblgenomes.org/id/b2756 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0004521 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004521 GO_process GO:0006396 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006396 GO_process GO:0051607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051607 GO_process GO:0090502 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090502 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_process GO:0002376 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403 GeneID 947226 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947226 HOGENOM HOG000015851 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000015851&db=HOGENOM6 InParanoid Q46897 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46897 IntAct Q46897 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46897* IntEnz 3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1 InterPro IPR010179 http://www.ebi.ac.uk/interpro/entry/IPR010179 KEGG_Gene ecj:JW2726 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2726 KEGG_Gene eco:b2756 http://www.genome.jp/dbget-bin/www_bget?eco:b2756 OMA HRSGTHI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HRSGTHI PDB 4DZD http://www.ebi.ac.uk/pdbe-srv/view/entry/4DZD PDB 4QYZ http://www.ebi.ac.uk/pdbe-srv/view/entry/4QYZ PDB 4TVX http://www.ebi.ac.uk/pdbe-srv/view/entry/4TVX PDB 4U7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U7U PDB 5CD4 http://www.ebi.ac.uk/pdbe-srv/view/entry/5CD4 PDB 5H9E http://www.ebi.ac.uk/pdbe-srv/view/entry/5H9E PDB 5H9F http://www.ebi.ac.uk/pdbe-srv/view/entry/5H9F PDBsum 4DZD http://www.ebi.ac.uk/pdbsum/4DZD PDBsum 4QYZ http://www.ebi.ac.uk/pdbsum/4QYZ PDBsum 4TVX http://www.ebi.ac.uk/pdbsum/4TVX PDBsum 4U7U http://www.ebi.ac.uk/pdbsum/4U7U PDBsum 5CD4 http://www.ebi.ac.uk/pdbsum/5CD4 PDBsum 5H9E http://www.ebi.ac.uk/pdbsum/5H9E PDBsum 5H9F http://www.ebi.ac.uk/pdbsum/5H9F PSORT swissprot:CAS6_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CAS6_ECOLI PSORT-B swissprot:CAS6_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CAS6_ECOLI PSORT2 swissprot:CAS6_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CAS6_ECOLI Pfam PF08798 http://pfam.xfam.org/family/PF08798 Phobius swissprot:CAS6_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CAS6_ECOLI ProteinModelPortal Q46897 http://www.proteinmodelportal.org/query/uniprot/Q46897 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18703739 http://www.ncbi.nlm.nih.gov/pubmed/18703739 PubMed 19429622 http://www.ncbi.nlm.nih.gov/pubmed/19429622 PubMed 20132443 http://www.ncbi.nlm.nih.gov/pubmed/20132443 PubMed 21219465 http://www.ncbi.nlm.nih.gov/pubmed/21219465 PubMed 21255106 http://www.ncbi.nlm.nih.gov/pubmed/21255106 PubMed 21460843 http://www.ncbi.nlm.nih.gov/pubmed/21460843 PubMed 21699496 http://www.ncbi.nlm.nih.gov/pubmed/21699496 PubMed 21938068 http://www.ncbi.nlm.nih.gov/pubmed/21938068 PubMed 22521689 http://www.ncbi.nlm.nih.gov/pubmed/22521689 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417236 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417236 RefSeq WP_000281400 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000281400 SMART SM01101 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01101 SMR Q46897 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46897 STRING 511145.b2756 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2756&targetmode=cogs TIGRFAMs TIGR01907 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01907 UniProtKB CAS6_ECOLI http://www.uniprot.org/uniprot/CAS6_ECOLI UniProtKB-AC Q46897 http://www.uniprot.org/uniprot/Q46897 charge swissprot:CAS6_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CAS6_ECOLI eggNOG ENOG4108Y7V http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Y7V eggNOG ENOG410ZWC5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZWC5 epestfind swissprot:CAS6_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CAS6_ECOLI garnier swissprot:CAS6_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CAS6_ECOLI helixturnhelix swissprot:CAS6_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CAS6_ECOLI hmoment swissprot:CAS6_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CAS6_ECOLI iep swissprot:CAS6_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CAS6_ECOLI inforesidue swissprot:CAS6_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CAS6_ECOLI octanol swissprot:CAS6_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CAS6_ECOLI pepcoil swissprot:CAS6_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CAS6_ECOLI pepdigest swissprot:CAS6_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CAS6_ECOLI pepinfo swissprot:CAS6_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CAS6_ECOLI pepnet swissprot:CAS6_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CAS6_ECOLI pepstats swissprot:CAS6_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CAS6_ECOLI pepwheel swissprot:CAS6_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CAS6_ECOLI pepwindow swissprot:CAS6_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CAS6_ECOLI sigcleave swissprot:CAS6_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CAS6_ECOLI ## Database ID URL or Descriptions # BioGrid 4263086 10 # EcoGene EG12460 yjcZ # InterPro IPR025599 YjcZ # Organism YJCZ_ECOLI Escherichia coli (strain K12) # PATRIC 32123785 VBIEscCol129921_4241 # PIR S56338 S56338 # Pfam PF13990 YjcZ # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJCZ_ECOLI Uncharacterized protein YjcZ # RefSeq NP_418534 NC_000913.3 # RefSeq WP_000169188 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97009.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # eggNOG ENOG4108YIV Bacteria # eggNOG ENOG4111JPB LUCA BLAST swissprot:YJCZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJCZ_ECOLI BioCyc ECOL316407:JW5729-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5729-MONOMER BioCyc EcoCyc:G7823-MONOMER http://biocyc.org/getid?id=EcoCyc:G7823-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2354 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2354 EcoGene EG12460 http://www.ecogene.org/geneInfo.php?eg_id=EG12460 EnsemblBacteria AAC77071 http://www.ensemblgenomes.org/id/AAC77071 EnsemblBacteria AAC77071 http://www.ensemblgenomes.org/id/AAC77071 EnsemblBacteria BAE78112 http://www.ensemblgenomes.org/id/BAE78112 EnsemblBacteria BAE78112 http://www.ensemblgenomes.org/id/BAE78112 EnsemblBacteria BAE78112 http://www.ensemblgenomes.org/id/BAE78112 EnsemblBacteria b4110 http://www.ensemblgenomes.org/id/b4110 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 948633 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948633 HOGENOM HOG000127030 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000127030&db=HOGENOM6 InterPro IPR025599 http://www.ebi.ac.uk/interpro/entry/IPR025599 KEGG_Gene ecj:JW5729 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5729 KEGG_Gene eco:b4110 http://www.genome.jp/dbget-bin/www_bget?eco:b4110 OMA MLESVYP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MLESVYP PSORT swissprot:YJCZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJCZ_ECOLI PSORT-B swissprot:YJCZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJCZ_ECOLI PSORT2 swissprot:YJCZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJCZ_ECOLI Pfam PF13990 http://pfam.xfam.org/family/PF13990 Phobius swissprot:YJCZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJCZ_ECOLI ProteinModelPortal P39267 http://www.proteinmodelportal.org/query/uniprot/P39267 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418534 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418534 RefSeq WP_000169188 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000169188 STRING 511145.b4110 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4110&targetmode=cogs UniProtKB YJCZ_ECOLI http://www.uniprot.org/uniprot/YJCZ_ECOLI UniProtKB-AC P39267 http://www.uniprot.org/uniprot/P39267 charge swissprot:YJCZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJCZ_ECOLI eggNOG ENOG4108YIV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108YIV eggNOG ENOG4111JPB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111JPB epestfind swissprot:YJCZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJCZ_ECOLI garnier swissprot:YJCZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJCZ_ECOLI helixturnhelix swissprot:YJCZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJCZ_ECOLI hmoment swissprot:YJCZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJCZ_ECOLI iep swissprot:YJCZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJCZ_ECOLI inforesidue swissprot:YJCZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJCZ_ECOLI octanol swissprot:YJCZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJCZ_ECOLI pepcoil swissprot:YJCZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJCZ_ECOLI pepdigest swissprot:YJCZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJCZ_ECOLI pepinfo swissprot:YJCZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJCZ_ECOLI pepnet swissprot:YJCZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJCZ_ECOLI pepstats swissprot:YJCZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJCZ_ECOLI pepwheel swissprot:YJCZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJCZ_ECOLI pepwindow swissprot:YJCZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJCZ_ECOLI sigcleave swissprot:YJCZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJCZ_ECOLI ## Database ID URL or Descriptions # BioGrid 4263244 5 # EcoGene EG12453 rraB # FUNCTION RRAB_ECOLI Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. {ECO 0000255|HAMAP-Rule MF_01888, ECO 0000269|PubMed 16771842, ECO 0000269|PubMed 18510556}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008428 ribonuclease inhibitor activity; IDA:EcoCyc. # GO_function GO:0019899 enzyme binding; IPI:EcoCyc. # GO_function GO:0060698 endoribonuclease inhibitor activity; IDA:UniProtKB. # GO_process GO:0006402 mRNA catabolic process; IDA:EcoCyc. # GO_process GO:0050790 regulation of catalytic activity; IDA:EcoCyc. # GO_process GO:0060699 regulation of endoribonuclease activity; IDA:UniProtKB. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0019899 enzyme binding # GOslim_function GO:0030234 enzyme regulator activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # Gene3D 3.30.70.970 -; 1. # HAMAP MF_01888 RraB # INDUCTION Constitutively expressed. Expression is increased by a reduction in intracellular concentration of UDP-GlcNAc. {ECO:0000269|PubMed 19717586}. # INTERACTION RRAB_ECOLI P0A9Z1 glnB; NbExp=2; IntAct=EBI-544031, EBI-551053; # IntAct P0AF90 16 # InterPro IPR009671 RraB_dom # InterPro IPR016716 RraB # MISCELLANEOUS RRAB_ECOLI RraA and RraB interact with Rne at separate sites within the Rne and exert distinct effects on the composition of the degradosome, affecting distinct sets of RNA transcripts. # Organism RRAB_ECOLI Escherichia coli (strain K12) # PATRIC 32124081 VBIEscCol129921_4385 # PIR S56480 S56480 # PIRSF PIRSF018193 UCP018193 # Pfam PF06877 RraB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Regulator of ribonuclease activity B {ECO:0000255|HAMAP-Rule MF_01888} # RefSeq NP_418676 NC_000913.3 # RefSeq WP_000002953 NZ_LN832404.1 # SIMILARITY Belongs to the RraB family. {ECO:0000255|HAMAP- Rule MF_01888}. # SUBCELLULAR LOCATION RRAB_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_01888}. # SUBUNIT RRAB_ECOLI Interacts with the C-terminal region of Rne. {ECO 0000255|HAMAP-Rule MF_01888, ECO 0000269|PubMed 16771842}. # SUPFAM SSF89946 SSF89946 # eggNOG COG3076 LUCA # eggNOG ENOG4105KQT Bacteria BLAST swissprot:RRAB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RRAB_ECOLI BioCyc ECOL316407:JW4212-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4212-MONOMER BioCyc EcoCyc:G7885-MONOMER http://biocyc.org/getid?id=EcoCyc:G7885-MONOMER COG COG3076 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3076 DIP DIP-47905N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47905N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1111/j.1365-2958.2006.05246.x http://dx.doi.org/10.1111/j.1365-2958.2006.05246.x DOI 10.1111/j.1574-6968.2008.01205.x http://dx.doi.org/10.1111/j.1574-6968.2008.01205.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00344-09 http://dx.doi.org/10.1128/JB.00344-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M24186 http://www.ebi.ac.uk/ena/data/view/M24186 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2347 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2347 EcoGene EG12453 http://www.ecogene.org/geneInfo.php?eg_id=EG12453 EnsemblBacteria AAC77212 http://www.ensemblgenomes.org/id/AAC77212 EnsemblBacteria AAC77212 http://www.ensemblgenomes.org/id/AAC77212 EnsemblBacteria BAE78252 http://www.ensemblgenomes.org/id/BAE78252 EnsemblBacteria BAE78252 http://www.ensemblgenomes.org/id/BAE78252 EnsemblBacteria BAE78252 http://www.ensemblgenomes.org/id/BAE78252 EnsemblBacteria b4255 http://www.ensemblgenomes.org/id/b4255 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008428 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008428 GO_function GO:0019899 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899 GO_function GO:0060698 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060698 GO_process GO:0006402 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006402 GO_process GO:0050790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050790 GO_process GO:0060699 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060699 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0019899 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899 GOslim_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 Gene3D 3.30.70.970 http://www.cathdb.info/version/latest/superfamily/3.30.70.970 GeneID 948773 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948773 HAMAP MF_01888 http://hamap.expasy.org/unirule/MF_01888 HOGENOM HOG000282487 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000282487&db=HOGENOM6 IntAct P0AF90 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AF90* InterPro IPR009671 http://www.ebi.ac.uk/interpro/entry/IPR009671 InterPro IPR016716 http://www.ebi.ac.uk/interpro/entry/IPR016716 KEGG_Gene ecj:JW4212 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4212 KEGG_Gene eco:b4255 http://www.genome.jp/dbget-bin/www_bget?eco:b4255 KEGG_Orthology KO:K09893 http://www.genome.jp/dbget-bin/www_bget?KO:K09893 MINT MINT-1243800 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1243800 OMA FCFDAIA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FCFDAIA PSORT swissprot:RRAB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RRAB_ECOLI PSORT-B swissprot:RRAB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RRAB_ECOLI PSORT2 swissprot:RRAB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RRAB_ECOLI Pfam PF06877 http://pfam.xfam.org/family/PF06877 Phobius swissprot:RRAB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RRAB_ECOLI ProteinModelPortal P0AF90 http://www.proteinmodelportal.org/query/uniprot/P0AF90 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16771842 http://www.ncbi.nlm.nih.gov/pubmed/16771842 PubMed 18510556 http://www.ncbi.nlm.nih.gov/pubmed/18510556 PubMed 19717586 http://www.ncbi.nlm.nih.gov/pubmed/19717586 PubMed 6329710 http://www.ncbi.nlm.nih.gov/pubmed/6329710 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8253666 http://www.ncbi.nlm.nih.gov/pubmed/8253666 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418676 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418676 RefSeq WP_000002953 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000002953 SMR P0AF90 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AF90 STRING 511145.b4255 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4255&targetmode=cogs STRING COG3076 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3076&targetmode=cogs SUPFAM SSF89946 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF89946 UniProtKB RRAB_ECOLI http://www.uniprot.org/uniprot/RRAB_ECOLI UniProtKB-AC P0AF90 http://www.uniprot.org/uniprot/P0AF90 charge swissprot:RRAB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RRAB_ECOLI eggNOG COG3076 http://eggnogapi.embl.de/nog_data/html/tree/COG3076 eggNOG ENOG4105KQT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KQT epestfind swissprot:RRAB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RRAB_ECOLI garnier swissprot:RRAB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RRAB_ECOLI helixturnhelix swissprot:RRAB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RRAB_ECOLI hmoment swissprot:RRAB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RRAB_ECOLI iep swissprot:RRAB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RRAB_ECOLI inforesidue swissprot:RRAB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RRAB_ECOLI octanol swissprot:RRAB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RRAB_ECOLI pepcoil swissprot:RRAB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RRAB_ECOLI pepdigest swissprot:RRAB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RRAB_ECOLI pepinfo swissprot:RRAB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RRAB_ECOLI pepnet swissprot:RRAB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RRAB_ECOLI pepstats swissprot:RRAB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RRAB_ECOLI pepwheel swissprot:RRAB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RRAB_ECOLI pepwindow swissprot:RRAB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RRAB_ECOLI sigcleave swissprot:RRAB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RRAB_ECOLI ## Database ID URL or Descriptions # BioGrid 4259900 11 # DISRUPTION PHENOTYPE Mutant shows a significant reduction in the level of Ndk. {ECO:0000269|PubMed 8596442}. # DOMAIN RNK_ECOLI Contains a short N-terminal coiled-coil domain and a C- terminal globular domain. {ECO 0000269|PubMed 18760284}. # EcoGene EG12637 rnk # FUNCTION RNK_ECOLI May act as an anti-Gre factor. Regulates the level of the nucleoside diphosphate kinase Ndk. {ECO 0000255|HAMAP- Rule MF_00954, ECO 0000269|PubMed 18760284, ECO 0000269|PubMed 8596442}. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_process GO:0032784 regulation of DNA-templated transcription, elongation; IEA:InterPro. # GO_process GO:0065007 biological regulation; IMP:EcoCyc. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # Gene3D 3.10.50.30 -; 1. # HAMAP MF_00954 Rnk # INTERACTION RNK_ECOLI P0ACJ0 lrp; NbExp=4; IntAct=EBI-553769, EBI-1113316; P77174 ybdM; NbExp=5; IntAct=EBI-553769, EBI-1118992; # IntAct P0AFW4 28 # InterPro IPR001437 Tscrpt_elong_fac_GreA/B_C # InterPro IPR028625 Rnk # InterPro IPR029462 Rnk_N # KEGG_Brite ko03000 Transcription factors # MISCELLANEOUS Can restore alginate synthesis and Ndk activity in the aglQ mutant of P.aeruginosa. {ECO:0000305|PubMed 7565093}. # Organism RNK_ECOLI Escherichia coli (strain K12) # PATRIC 32116400 VBIEscCol129921_0640 # PDB 3BMB X-ray; 1.91 A; A/B=1-136 # PIR I57917 I57917 # Pfam PF01272 GreA_GreB # Pfam PF14760 Rnk_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Regulator of nucleoside diphosphate kinase {ECO:0000255|HAMAP-Rule MF_00954} # RefSeq NP_415143 NC_000913.3 # RefSeq WP_000089731 NZ_LN832404.1 # SIMILARITY Belongs to the Rnk family. {ECO:0000255|HAMAP- Rule MF_00954}. # SUBUNIT RNK_ECOLI Interacts with the RNA polymerase. {ECO 0000255|HAMAP- Rule MF_00954, ECO 0000269|PubMed 18760284}. # eggNOG COG0782 LUCA # eggNOG ENOG4105NXH Bacteria BLAST swissprot:RNK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RNK_ECOLI BioCyc ECOL316407:JW0602-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0602-MONOMER BioCyc EcoCyc:G6337-MONOMER http://biocyc.org/getid?id=EcoCyc:G6337-MONOMER COG COG0782 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0782 DIP DIP-48048N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48048N DOI 10.1016/j.jmb.2008.08.011 http://dx.doi.org/10.1016/j.jmb.2008.08.011 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1995.mmi_17050935.x http://dx.doi.org/10.1111/j.1365-2958.1995.mmi_17050935.x DOI 10.1111/j.1365-2958.1995.tb02303.x http://dx.doi.org/10.1111/j.1365-2958.1995.tb02303.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L37900 http://www.ebi.ac.uk/ena/data/view/L37900 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB2518 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2518 EcoGene EG12637 http://www.ecogene.org/geneInfo.php?eg_id=EG12637 EnsemblBacteria AAC73711 http://www.ensemblgenomes.org/id/AAC73711 EnsemblBacteria AAC73711 http://www.ensemblgenomes.org/id/AAC73711 EnsemblBacteria BAA35239 http://www.ensemblgenomes.org/id/BAA35239 EnsemblBacteria BAA35239 http://www.ensemblgenomes.org/id/BAA35239 EnsemblBacteria BAA35239 http://www.ensemblgenomes.org/id/BAA35239 EnsemblBacteria b0610 http://www.ensemblgenomes.org/id/b0610 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0032784 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032784 GO_process GO:0065007 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0065007 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.10.50.30 http://www.cathdb.info/version/latest/superfamily/3.10.50.30 GeneID 947546 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947546 HAMAP MF_00954 http://hamap.expasy.org/unirule/MF_00954 HOGENOM HOG000208216 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000208216&db=HOGENOM6 InParanoid P0AFW4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFW4 IntAct P0AFW4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFW4* InterPro IPR001437 http://www.ebi.ac.uk/interpro/entry/IPR001437 InterPro IPR028625 http://www.ebi.ac.uk/interpro/entry/IPR028625 InterPro IPR029462 http://www.ebi.ac.uk/interpro/entry/IPR029462 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW0602 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0602 KEGG_Gene eco:b0610 http://www.genome.jp/dbget-bin/www_bget?eco:b0610 KEGG_Orthology KO:K06140 http://www.genome.jp/dbget-bin/www_bget?KO:K06140 MINT MINT-1300098 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1300098 OMA LAVEYQP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LAVEYQP PDB 3BMB http://www.ebi.ac.uk/pdbe-srv/view/entry/3BMB PDBsum 3BMB http://www.ebi.ac.uk/pdbsum/3BMB PSORT swissprot:RNK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RNK_ECOLI PSORT-B swissprot:RNK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RNK_ECOLI PSORT2 swissprot:RNK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RNK_ECOLI Pfam PF01272 http://pfam.xfam.org/family/PF01272 Pfam PF14760 http://pfam.xfam.org/family/PF14760 Phobius swissprot:RNK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RNK_ECOLI PhylomeDB P0AFW4 http://phylomedb.org/?seqid=P0AFW4 ProteinModelPortal P0AFW4 http://www.proteinmodelportal.org/query/uniprot/P0AFW4 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18760284 http://www.ncbi.nlm.nih.gov/pubmed/18760284 PubMed 7565093 http://www.ncbi.nlm.nih.gov/pubmed/7565093 PubMed 8596442 http://www.ncbi.nlm.nih.gov/pubmed/8596442 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415143 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415143 RefSeq WP_000089731 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000089731 SMR P0AFW4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFW4 STRING 511145.b0610 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0610&targetmode=cogs STRING COG0782 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0782&targetmode=cogs UniProtKB RNK_ECOLI http://www.uniprot.org/uniprot/RNK_ECOLI UniProtKB-AC P0AFW4 http://www.uniprot.org/uniprot/P0AFW4 charge swissprot:RNK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RNK_ECOLI eggNOG COG0782 http://eggnogapi.embl.de/nog_data/html/tree/COG0782 eggNOG ENOG4105NXH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105NXH epestfind swissprot:RNK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RNK_ECOLI garnier swissprot:RNK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RNK_ECOLI helixturnhelix swissprot:RNK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RNK_ECOLI hmoment swissprot:RNK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RNK_ECOLI iep swissprot:RNK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RNK_ECOLI inforesidue swissprot:RNK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RNK_ECOLI octanol swissprot:RNK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RNK_ECOLI pepcoil swissprot:RNK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RNK_ECOLI pepdigest swissprot:RNK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RNK_ECOLI pepinfo swissprot:RNK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RNK_ECOLI pepnet swissprot:RNK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RNK_ECOLI pepstats swissprot:RNK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RNK_ECOLI pepwheel swissprot:RNK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RNK_ECOLI pepwindow swissprot:RNK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RNK_ECOLI sigcleave swissprot:RNK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RNK_ECOLI ## Database ID URL or Descriptions # AltName PAAK_ECOLI Phenylacetyl-CoA ligase # BioGrid 4263013 319 # CATALYTIC ACTIVITY PAAK_ECOLI ATP + phenylacetate + CoA = AMP + diphosphate + phenylacetyl-CoA. # EcoGene EG13745 paaK # FUNCTION PAAK_ECOLI Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA). {ECO 0000269|PubMed 20660314, ECO 0000269|PubMed 9748275}. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016405 CoA-ligase activity; IMP:EcoliWiki. # GO_function GO:0047475 phenylacetate-CoA ligase activity; IMP:EcoliWiki. # GO_process GO:0010124 phenylacetate catabolic process; IMP:UniProtKB. # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # INDUCTION PAAK_ECOLI Activated by cAMP receptor protein (CRP), integration host factor (IHF) and by phenylacetyl-coenzyme A that prevents PaaX from binding its target sequences. Inhibited by PaaX. {ECO 0000269|PubMed 10766858, ECO 0000269|PubMed 9748275}. # InterPro IPR000873 AMP-dep_Synth/Lig # InterPro IPR011880 PA_CoA_ligase # InterPro IPR028154 AMP-dep_Lig_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00360 Phenylalanine metabolism # Organism PAAK_ECOLI Escherichia coli (strain K12) # PATHWAY PAAK_ECOLI Aromatic compound metabolism; phenylacetate degradation. # PATRIC 32118082 VBIEscCol129921_1461 # PIR A64891 A64891 # PIRSF PIRSF006444 PaaK # Pfam PF00501 AMP-binding # Pfam PF14535 AMP-binding_C_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PAAK_ECOLI Phenylacetate-coenzyme A ligase # RefSeq NP_415916 NC_000913.3 # RefSeq WP_000632280 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA66100.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the phenylacetyl-CoA ligase family. {ECO 0000305}. # SUBUNIT Monomer. {ECO 0000250}. # TIGRFAMs TIGR02155 PA_CoA_ligase # eggNOG COG1541 LUCA # eggNOG ENOG4105DZS Bacteria BLAST swissprot:PAAK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PAAK_ECOLI BioCyc ECOL316407:JW5218-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5218-MONOMER BioCyc EcoCyc:G6719-MONOMER http://biocyc.org/getid?id=EcoCyc:G6719-MONOMER COG COG1541 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1541 DIP DIP-10430N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10430N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.1005399107 http://dx.doi.org/10.1073/pnas.1005399107 DOI 10.1074/jbc.273.40.25974 http://dx.doi.org/10.1074/jbc.273.40.25974 DOI 10.1074/jbc.275.16.12214 http://dx.doi.org/10.1074/jbc.275.16.12214 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.2.1.30 http://www.genome.jp/dbget-bin/www_bget?EC:6.2.1.30 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X97452 http://www.ebi.ac.uk/ena/data/view/X97452 ENZYME 6.2.1.30 http://enzyme.expasy.org/EC/6.2.1.30 EchoBASE EB3508 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3508 EcoGene EG13745 http://www.ecogene.org/geneInfo.php?eg_id=EG13745 EnsemblBacteria AAC74480 http://www.ensemblgenomes.org/id/AAC74480 EnsemblBacteria AAC74480 http://www.ensemblgenomes.org/id/AAC74480 EnsemblBacteria BAE76428 http://www.ensemblgenomes.org/id/BAE76428 EnsemblBacteria BAE76428 http://www.ensemblgenomes.org/id/BAE76428 EnsemblBacteria BAE76428 http://www.ensemblgenomes.org/id/BAE76428 EnsemblBacteria b1398 http://www.ensemblgenomes.org/id/b1398 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016405 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016405 GO_function GO:0047475 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047475 GO_process GO:0010124 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010124 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 945963 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945963 HOGENOM HOG000197614 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000197614&db=HOGENOM6 InParanoid P76085 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76085 IntEnz 6.2.1.30 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.2.1.30 InterPro IPR000873 http://www.ebi.ac.uk/interpro/entry/IPR000873 InterPro IPR011880 http://www.ebi.ac.uk/interpro/entry/IPR011880 InterPro IPR028154 http://www.ebi.ac.uk/interpro/entry/IPR028154 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5218 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5218 KEGG_Gene eco:b1398 http://www.genome.jp/dbget-bin/www_bget?eco:b1398 KEGG_Orthology KO:K01912 http://www.genome.jp/dbget-bin/www_bget?KO:K01912 KEGG_Pathway ko00360 http://www.genome.jp/kegg-bin/show_pathway?ko00360 KEGG_Reaction rn:R02539 http://www.genome.jp/dbget-bin/www_bget?rn:R02539 OMA GSHIWED http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GSHIWED PSORT swissprot:PAAK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PAAK_ECOLI PSORT-B swissprot:PAAK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PAAK_ECOLI PSORT2 swissprot:PAAK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PAAK_ECOLI Pfam PF00501 http://pfam.xfam.org/family/PF00501 Pfam PF14535 http://pfam.xfam.org/family/PF14535 Phobius swissprot:PAAK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PAAK_ECOLI PhylomeDB P76085 http://phylomedb.org/?seqid=P76085 ProteinModelPortal P76085 http://www.proteinmodelportal.org/query/uniprot/P76085 PubMed 10766858 http://www.ncbi.nlm.nih.gov/pubmed/10766858 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20660314 http://www.ncbi.nlm.nih.gov/pubmed/20660314 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9748275 http://www.ncbi.nlm.nih.gov/pubmed/9748275 RefSeq NP_415916 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415916 RefSeq WP_000632280 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000632280 SMR P76085 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76085 STRING 511145.b1398 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1398&targetmode=cogs STRING COG1541 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1541&targetmode=cogs TIGRFAMs TIGR02155 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02155 UniProtKB PAAK_ECOLI http://www.uniprot.org/uniprot/PAAK_ECOLI UniProtKB-AC P76085 http://www.uniprot.org/uniprot/P76085 charge swissprot:PAAK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PAAK_ECOLI eggNOG COG1541 http://eggnogapi.embl.de/nog_data/html/tree/COG1541 eggNOG ENOG4105DZS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DZS epestfind swissprot:PAAK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PAAK_ECOLI garnier swissprot:PAAK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PAAK_ECOLI helixturnhelix swissprot:PAAK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PAAK_ECOLI hmoment swissprot:PAAK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PAAK_ECOLI iep swissprot:PAAK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PAAK_ECOLI inforesidue swissprot:PAAK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PAAK_ECOLI octanol swissprot:PAAK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PAAK_ECOLI pepcoil swissprot:PAAK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PAAK_ECOLI pepdigest swissprot:PAAK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PAAK_ECOLI pepinfo swissprot:PAAK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PAAK_ECOLI pepnet swissprot:PAAK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PAAK_ECOLI pepstats swissprot:PAAK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PAAK_ECOLI pepwheel swissprot:PAAK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PAAK_ECOLI pepwindow swissprot:PAAK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PAAK_ECOLI sigcleave swissprot:PAAK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PAAK_ECOLI ## Database ID URL or Descriptions # AltName L-fuculose-1-phosphate aldolase {ECO:0000255|HAMAP-Rule MF_00987} # BIOPHYSICOCHEMICAL PROPERTIES pH dependence: Optimum pH is 7.2. {ECO 0000269|PubMed:13898172}; # BRENDA 4.1.2.17 2026 # BioGrid 4259224 20 # CATALYTIC ACTIVITY FUCA_ECOLI L-fuculose 1-phosphate = glycerone phosphate + (S)-lactaldehyde. {ECO 0000255|HAMAP-Rule MF_00987, ECO 0000269|PubMed 13898172}. # COFACTOR FUCA_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000255|HAMAP-Rule MF_00987, ECO 0000269|PubMed 15299567, ECO 0000269|PubMed 8515438, ECO 0000269|PubMed 8676381}; Note=Binds 1 zinc ion per subunit. {ECO 0000255|HAMAP- Rule MF_00987, ECO 0000269|PubMed 15299567, ECO 0000269|PubMed 8515438, ECO 0000269|PubMed 8676381}; # EcoGene EG10348 fucA # FUNCTION FUCA_ECOLI Catalyzes the cleavage of L-fuculose 1-phosphate to glycerone phosphate and L-lactaldehyde. {ECO 0000255|HAMAP- Rule MF_00987, ECO 0000269|PubMed 13898172}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0008270 zinc ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008738 L-fuculose-phosphate aldolase activity; IDA:EcoCyc. # GO_function GO:0016832 aldehyde-lyase activity; IDA:EcoCyc. # GO_process GO:0019571 D-arabinose catabolic process; IMP:EcoCyc. # GO_process GO:0042355 L-fucose catabolic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.225.10 -; 1. # HAMAP MF_00987 FucA # InterPro IPR001303 Aldolase_II/adducin_N # InterPro IPR004782 FucA # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00051 Fructose and mannose metabolism # Organism FUCA_ECOLI Escherichia coli (strain K12) # PATHWAY FUCA_ECOLI Carbohydrate degradation; L-fucose degradation; L- lactaldehyde and glycerone phosphate from L-fucose step 3/3. {ECO 0000255|HAMAP-Rule MF_00987, ECO 0000269|PubMed 13898172}. # PATRIC 32121016 VBIEscCol129921_2900 # PDB 1DZU X-ray; 2.09 A; P=1-215 # PDB 1DZV X-ray; 1.86 A; P=1-215 # PDB 1DZW X-ray; 2.17 A; P=1-215 # PDB 1DZX X-ray; 2.18 A; P=1-215 # PDB 1DZY X-ray; 2.44 A; P=1-213 # PDB 1DZZ X-ray; 1.92 A; P=1-215 # PDB 1E46 X-ray; 2.55 A; P=1-215 # PDB 1E47 X-ray; 2.15 A; P=1-215 # PDB 1E48 X-ray; 1.97 A; P=1-215 # PDB 1E49 X-ray; 2.53 A; P=1-215 # PDB 1E4A X-ray; 2.15 A; P=1-215 # PDB 1E4B X-ray; 1.84 A; P=1-215 # PDB 1E4C X-ray; 1.66 A; P=1-215 # PDB 1FUA X-ray; 1.92 A; A=1-215 # PDB 2FUA X-ray; 2.00 A; A=1-215 # PDB 3FUA X-ray; 2.67 A; A=1-215 # PDB 4FUA X-ray; 2.43 A; A=1-215 # PIR B33495 ADECFP # Pfam PF00596 Aldolase_II # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName L-fuculose phosphate aldolase {ECO:0000255|HAMAP-Rule MF_00987} # RefSeq NP_417280 NC_000913.3 # RefSeq WP_000440781 NZ_LN832404.1 # SIMILARITY Belongs to the aldolase class II family. AraD/FucA subfamily. {ECO:0000255|HAMAP-Rule MF_00987}. # SMART SM01007 Aldolase_II # SUBUNIT FUCA_ECOLI Homotetramer. {ECO 0000255|HAMAP-Rule MF_00987, ECO 0000269|PubMed 10821675, ECO 0000269|PubMed 15299567, ECO 0000269|PubMed 8515438, ECO 0000269|PubMed 8676381}. # SUPFAM SSF53639 SSF53639 # TIGRFAMs TIGR01086 fucA # UniPathway UPA00563 UER00626 # eggNOG COG0235 LUCA # eggNOG ENOG4107W7X Bacteria BLAST swissprot:FUCA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FUCA_ECOLI BioCyc ECOL316407:JW2771-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2771-MONOMER BioCyc EcoCyc:FUCPALDOL-MONOMER http://biocyc.org/getid?id=EcoCyc:FUCPALDOL-MONOMER BioCyc MetaCyc:FUCPALDOL-MONOMER http://biocyc.org/getid?id=MetaCyc:FUCPALDOL-MONOMER COG COG0235 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0235 DIP DIP-9710N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9710N DOI 10.1006/jmbi.1993.1307 http://dx.doi.org/10.1006/jmbi.1993.1307 DOI 10.1006/jmbi.1996.0332 http://dx.doi.org/10.1006/jmbi.1996.0332 DOI 10.1006/jmbi.2000.4153 http://dx.doi.org/10.1006/jmbi.2000.4153 DOI 10.1021/bi9927686 http://dx.doi.org/10.1021/bi9927686 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/17.12.4883 http://dx.doi.org/10.1093/nar/17.12.4883 DOI 10.1107/S0907444996009146 http://dx.doi.org/10.1107/S0907444996009146 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.1.2.17 {ECO:0000255|HAMAP-Rule:MF_00987} http://www.genome.jp/dbget-bin/www_bget?EC:4.1.2.17 {ECO:0000255|HAMAP-Rule:MF_00987} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M27177 http://www.ebi.ac.uk/ena/data/view/M27177 EMBL M31059 http://www.ebi.ac.uk/ena/data/view/M31059 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 EMBL X15025 http://www.ebi.ac.uk/ena/data/view/X15025 ENZYME 4.1.2.17 {ECO:0000255|HAMAP-Rule:MF_00987} http://enzyme.expasy.org/EC/4.1.2.17 {ECO:0000255|HAMAP-Rule:MF_00987} EchoBASE EB0344 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0344 EcoGene EG10348 http://www.ecogene.org/geneInfo.php?eg_id=EG10348 EnsemblBacteria AAC75842 http://www.ensemblgenomes.org/id/AAC75842 EnsemblBacteria AAC75842 http://www.ensemblgenomes.org/id/AAC75842 EnsemblBacteria BAE76872 http://www.ensemblgenomes.org/id/BAE76872 EnsemblBacteria BAE76872 http://www.ensemblgenomes.org/id/BAE76872 EnsemblBacteria BAE76872 http://www.ensemblgenomes.org/id/BAE76872 EnsemblBacteria b2800 http://www.ensemblgenomes.org/id/b2800 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0008738 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008738 GO_function GO:0016832 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016832 GO_process GO:0019571 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019571 GO_process GO:0042355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042355 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.225.10 http://www.cathdb.info/version/latest/superfamily/3.40.225.10 GeneID 947282 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947282 HAMAP MF_00987 http://hamap.expasy.org/unirule/MF_00987 HOGENOM HOG000218184 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218184&db=HOGENOM6 InParanoid P0AB87 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AB87 IntAct P0AB87 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AB87* IntEnz 4.1.2.17 {ECO:0000255|HAMAP-Rule:MF_00987} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.2.17 {ECO:0000255|HAMAP-Rule:MF_00987} InterPro IPR001303 http://www.ebi.ac.uk/interpro/entry/IPR001303 InterPro IPR004782 http://www.ebi.ac.uk/interpro/entry/IPR004782 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2771 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2771 KEGG_Gene eco:b2800 http://www.genome.jp/dbget-bin/www_bget?eco:b2800 KEGG_Orthology KO:K01628 http://www.genome.jp/dbget-bin/www_bget?KO:K01628 KEGG_Pathway ko00051 http://www.genome.jp/kegg-bin/show_pathway?ko00051 KEGG_Reaction rn:R02262 http://www.genome.jp/dbget-bin/www_bget?rn:R02262 OMA YATFGTH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YATFGTH PDB 1DZU http://www.ebi.ac.uk/pdbe-srv/view/entry/1DZU PDB 1DZV http://www.ebi.ac.uk/pdbe-srv/view/entry/1DZV PDB 1DZW http://www.ebi.ac.uk/pdbe-srv/view/entry/1DZW PDB 1DZX http://www.ebi.ac.uk/pdbe-srv/view/entry/1DZX PDB 1DZY http://www.ebi.ac.uk/pdbe-srv/view/entry/1DZY PDB 1DZZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1DZZ PDB 1E46 http://www.ebi.ac.uk/pdbe-srv/view/entry/1E46 PDB 1E47 http://www.ebi.ac.uk/pdbe-srv/view/entry/1E47 PDB 1E48 http://www.ebi.ac.uk/pdbe-srv/view/entry/1E48 PDB 1E49 http://www.ebi.ac.uk/pdbe-srv/view/entry/1E49 PDB 1E4A http://www.ebi.ac.uk/pdbe-srv/view/entry/1E4A PDB 1E4B http://www.ebi.ac.uk/pdbe-srv/view/entry/1E4B PDB 1E4C http://www.ebi.ac.uk/pdbe-srv/view/entry/1E4C PDB 1FUA http://www.ebi.ac.uk/pdbe-srv/view/entry/1FUA PDB 2FUA http://www.ebi.ac.uk/pdbe-srv/view/entry/2FUA PDB 3FUA http://www.ebi.ac.uk/pdbe-srv/view/entry/3FUA PDB 4FUA http://www.ebi.ac.uk/pdbe-srv/view/entry/4FUA PDBsum 1DZU http://www.ebi.ac.uk/pdbsum/1DZU PDBsum 1DZV http://www.ebi.ac.uk/pdbsum/1DZV PDBsum 1DZW http://www.ebi.ac.uk/pdbsum/1DZW PDBsum 1DZX http://www.ebi.ac.uk/pdbsum/1DZX PDBsum 1DZY http://www.ebi.ac.uk/pdbsum/1DZY PDBsum 1DZZ http://www.ebi.ac.uk/pdbsum/1DZZ PDBsum 1E46 http://www.ebi.ac.uk/pdbsum/1E46 PDBsum 1E47 http://www.ebi.ac.uk/pdbsum/1E47 PDBsum 1E48 http://www.ebi.ac.uk/pdbsum/1E48 PDBsum 1E49 http://www.ebi.ac.uk/pdbsum/1E49 PDBsum 1E4A http://www.ebi.ac.uk/pdbsum/1E4A PDBsum 1E4B http://www.ebi.ac.uk/pdbsum/1E4B PDBsum 1E4C http://www.ebi.ac.uk/pdbsum/1E4C PDBsum 1FUA http://www.ebi.ac.uk/pdbsum/1FUA PDBsum 2FUA http://www.ebi.ac.uk/pdbsum/2FUA PDBsum 3FUA http://www.ebi.ac.uk/pdbsum/3FUA PDBsum 4FUA http://www.ebi.ac.uk/pdbsum/4FUA PSORT swissprot:FUCA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FUCA_ECOLI PSORT-B swissprot:FUCA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FUCA_ECOLI PSORT2 swissprot:FUCA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FUCA_ECOLI Pfam PF00596 http://pfam.xfam.org/family/PF00596 Phobius swissprot:FUCA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FUCA_ECOLI PhylomeDB P0AB87 http://phylomedb.org/?seqid=P0AB87 ProteinModelPortal P0AB87 http://www.proteinmodelportal.org/query/uniprot/P0AB87 PubMed 10821675 http://www.ncbi.nlm.nih.gov/pubmed/10821675 PubMed 11054289 http://www.ncbi.nlm.nih.gov/pubmed/11054289 PubMed 13898172 http://www.ncbi.nlm.nih.gov/pubmed/13898172 PubMed 15299567 http://www.ncbi.nlm.nih.gov/pubmed/15299567 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2553671 http://www.ncbi.nlm.nih.gov/pubmed/2553671 PubMed 2661535 http://www.ncbi.nlm.nih.gov/pubmed/2661535 PubMed 2664711 http://www.ncbi.nlm.nih.gov/pubmed/2664711 PubMed 8515438 http://www.ncbi.nlm.nih.gov/pubmed/8515438 PubMed 8676381 http://www.ncbi.nlm.nih.gov/pubmed/8676381 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417280 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417280 RefSeq WP_000440781 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000440781 SMART SM01007 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01007 SMR P0AB87 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AB87 STRING 511145.b2800 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2800&targetmode=cogs STRING COG0235 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0235&targetmode=cogs SUPFAM SSF53639 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53639 TIGRFAMs TIGR01086 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01086 UniProtKB FUCA_ECOLI http://www.uniprot.org/uniprot/FUCA_ECOLI UniProtKB-AC P0AB87 http://www.uniprot.org/uniprot/P0AB87 charge swissprot:FUCA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FUCA_ECOLI eggNOG COG0235 http://eggnogapi.embl.de/nog_data/html/tree/COG0235 eggNOG ENOG4107W7X http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107W7X epestfind swissprot:FUCA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FUCA_ECOLI garnier swissprot:FUCA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FUCA_ECOLI helixturnhelix swissprot:FUCA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FUCA_ECOLI hmoment swissprot:FUCA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FUCA_ECOLI iep swissprot:FUCA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FUCA_ECOLI inforesidue swissprot:FUCA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FUCA_ECOLI octanol swissprot:FUCA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FUCA_ECOLI pepcoil swissprot:FUCA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FUCA_ECOLI pepdigest swissprot:FUCA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FUCA_ECOLI pepinfo swissprot:FUCA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FUCA_ECOLI pepnet swissprot:FUCA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FUCA_ECOLI pepstats swissprot:FUCA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FUCA_ECOLI pepwheel swissprot:FUCA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FUCA_ECOLI pepwindow swissprot:FUCA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FUCA_ECOLI sigcleave swissprot:FUCA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FUCA_ECOLI ## Database ID URL or Descriptions # CAUTION Could be the product of a pseudogene. The original sequence is truncated by an IS5 element which is inserted between position 123 and 124. {ECO 0000305}. # EcoGene EG12811 yhcE # Organism YHCE_ECOLI Escherichia coli (strain K12) # PIR C65113 C65113 # Proteomes UP000000625 Chromosome # RecName YHCE_ECOLI Putative uncharacterized protein YhcE BLAST swissprot:YHCE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHCE_ECOLI BioCyc EcoCyc:G7671-MONOMER http://biocyc.org/getid?id=EcoCyc:G7671-MONOMER DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2662 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2662 EcoGene EG12811 http://www.ecogene.org/geneInfo.php?eg_id=EG12811 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv PSORT swissprot:YHCE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHCE_ECOLI PSORT-B swissprot:YHCE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHCE_ECOLI PSORT2 swissprot:YHCE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHCE_ECOLI Phobius swissprot:YHCE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHCE_ECOLI ProteinModelPortal P45421 http://www.proteinmodelportal.org/query/uniprot/P45421 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 UniProtKB YHCE_ECOLI http://www.uniprot.org/uniprot/YHCE_ECOLI UniProtKB-AC P45421 http://www.uniprot.org/uniprot/P45421 charge swissprot:YHCE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHCE_ECOLI epestfind swissprot:YHCE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHCE_ECOLI garnier swissprot:YHCE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHCE_ECOLI helixturnhelix swissprot:YHCE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHCE_ECOLI hmoment swissprot:YHCE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHCE_ECOLI iep swissprot:YHCE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHCE_ECOLI inforesidue swissprot:YHCE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHCE_ECOLI octanol swissprot:YHCE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHCE_ECOLI pepcoil swissprot:YHCE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHCE_ECOLI pepdigest swissprot:YHCE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHCE_ECOLI pepinfo swissprot:YHCE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHCE_ECOLI pepnet swissprot:YHCE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHCE_ECOLI pepstats swissprot:YHCE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHCE_ECOLI pepwheel swissprot:YHCE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHCE_ECOLI pepwindow swissprot:YHCE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHCE_ECOLI sigcleave swissprot:YHCE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHCE_ECOLI ## Database ID URL or Descriptions # BioGrid 4259462 12 # CATALYTIC ACTIVITY HCAD_ECOLI Reduced ferredoxin + NAD(+) = oxidized ferredoxin + NADH. # COFACTOR Name=FAD; Xref=ChEBI:CHEBI 57692; # EcoGene EG13460 hcaD # FUNCTION HCAD_ECOLI Part of the multicomponent 3-phenylpropionate dioxygenase, that converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP- dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol), respectively. # GO_component GO:0005623 cell; IEA:GOC. # GO_function GO:0008695 3-phenylpropionate dioxygenase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0008860 ferredoxin-NAD+ reductase activity; IEA:UniProtKB-EC. # GO_function GO:0050660 flavin adenine dinucleotide binding; IEA:InterPro. # GO_process GO:0019380 3-phenylpropionate catabolic process; IMP:EcoCyc. # GO_process GO:0019439 aromatic compound catabolic process; IEA:UniProtKB-HAMAP. # GO_process GO:0045454 cell redox homeostasis; IEA:InterPro. # GOslim_component GO:0005623 cell # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0042592 homeostatic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.30.390.30 -; 1. # Gene3D 3.50.50.60 -; 2. # HAMAP MF_01651 HcaD # INTERACTION HCAD_ECOLI P0A6Z6 nikR; NbExp=2; IntAct=EBI-1129389, EBI-562488; # IntAct P77650 7 # InterPro IPR004099 Pyr_nucl-diS_OxRdtase_dimer # InterPro IPR016156 FAD/NAD-linked_Rdtase_dimer # InterPro IPR023744 HcaD # InterPro IPR023753 FAD/NAD-binding_dom # InterPro IPR028202 Reductase_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00071 Fatty acid metabolism # KEGG_Pathway ko00360 Phenylalanine metabolism # KEGG_Pathway ko00361 Chlorocyclohexane and chlorobenzene degradation # KEGG_Pathway ko00362 Benzoate degradation # KEGG_Pathway ko00621 Dioxin degradation # KEGG_Pathway ko00622 Xylene degradation # KEGG_Pathway ko00623 Toluene degradation # KEGG_Pathway ko00625 Chloroalkane and chloroalkene degradation # KEGG_Pathway ko00627 Aminobenzoate degradation # KEGG_Pathway ko00642 Ethylbenzene degradation # Organism HCAD_ECOLI Escherichia coli (strain K12) # PATHWAY HCAD_ECOLI Aromatic compound metabolism; 3-phenylpropanoate degradation. # PATRIC 32120481 VBIEscCol129921_2643 # PIR E65031 E65031 # Pfam PF07992 Pyr_redox_2 # Pfam PF14759 Reductase_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HCAD_ECOLI 3-phenylpropionate/cinnamic acid dioxygenase ferredoxin--NAD(+) reductase component # RefSeq NP_417037 NC_000913.3 # RefSeq WP_000660788 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial ring-hydroxylating dioxygenase ferredoxin reductase family. {ECO 0000305}. # SUBUNIT This dioxygenase system consists of four proteins the two subunits of the hydroxylase component (HcaE and HcaF), a ferredoxin (HcaC) and a ferredoxin reductase (HcaD). # SUPFAM SSF51905 SSF51905 # SUPFAM SSF55424 SSF55424 # eggNOG COG0446 LUCA # eggNOG ENOG4108EQM Bacteria BLAST swissprot:HCAD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HCAD_ECOLI BioCyc ECOL316407:JW2526-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2526-MONOMER BioCyc EcoCyc:HCAD-MONOMER http://biocyc.org/getid?id=EcoCyc:HCAD-MONOMER BioCyc MetaCyc:HCAD-MONOMER http://biocyc.org/getid?id=MetaCyc:HCAD-MONOMER COG COG0446 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0446 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.18.1.3 http://www.genome.jp/dbget-bin/www_bget?EC:1.18.1.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL Y11070 http://www.ebi.ac.uk/ena/data/view/Y11070 ENZYME 1.18.1.3 http://enzyme.expasy.org/EC/1.18.1.3 EchoBASE EB3233 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3233 EcoGene EG13460 http://www.ecogene.org/geneInfo.php?eg_id=EG13460 EnsemblBacteria AAC75595 http://www.ensemblgenomes.org/id/AAC75595 EnsemblBacteria AAC75595 http://www.ensemblgenomes.org/id/AAC75595 EnsemblBacteria BAA16445 http://www.ensemblgenomes.org/id/BAA16445 EnsemblBacteria BAA16445 http://www.ensemblgenomes.org/id/BAA16445 EnsemblBacteria BAA16445 http://www.ensemblgenomes.org/id/BAA16445 EnsemblBacteria b2542 http://www.ensemblgenomes.org/id/b2542 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005623 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005623 GO_function GO:0008695 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008695 GO_function GO:0008860 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008860 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_process GO:0019380 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019380 GO_process GO:0019439 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019439 GO_process GO:0045454 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045454 GOslim_component GO:0005623 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005623 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.30.390.30 http://www.cathdb.info/version/latest/superfamily/3.30.390.30 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 GeneID 945427 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945427 HAMAP MF_01651 http://hamap.expasy.org/unirule/MF_01651 HOGENOM HOG000276711 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276711&db=HOGENOM6 InParanoid P77650 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77650 IntAct P77650 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77650* IntEnz 1.18.1.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.18.1.3 InterPro IPR004099 http://www.ebi.ac.uk/interpro/entry/IPR004099 InterPro IPR016156 http://www.ebi.ac.uk/interpro/entry/IPR016156 InterPro IPR023744 http://www.ebi.ac.uk/interpro/entry/IPR023744 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 InterPro IPR028202 http://www.ebi.ac.uk/interpro/entry/IPR028202 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2526 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2526 KEGG_Gene eco:b2542 http://www.genome.jp/dbget-bin/www_bget?eco:b2542 KEGG_Orthology KO:K00529 http://www.genome.jp/dbget-bin/www_bget?KO:K00529 KEGG_Pathway ko00071 http://www.genome.jp/kegg-bin/show_pathway?ko00071 KEGG_Pathway ko00360 http://www.genome.jp/kegg-bin/show_pathway?ko00360 KEGG_Pathway ko00361 http://www.genome.jp/kegg-bin/show_pathway?ko00361 KEGG_Pathway ko00362 http://www.genome.jp/kegg-bin/show_pathway?ko00362 KEGG_Pathway ko00621 http://www.genome.jp/kegg-bin/show_pathway?ko00621 KEGG_Pathway ko00622 http://www.genome.jp/kegg-bin/show_pathway?ko00622 KEGG_Pathway ko00623 http://www.genome.jp/kegg-bin/show_pathway?ko00623 KEGG_Pathway ko00625 http://www.genome.jp/kegg-bin/show_pathway?ko00625 KEGG_Pathway ko00627 http://www.genome.jp/kegg-bin/show_pathway?ko00627 KEGG_Pathway ko00642 http://www.genome.jp/kegg-bin/show_pathway?ko00642 KEGG_Reaction rn:R00823 http://www.genome.jp/dbget-bin/www_bget?rn:R00823 KEGG_Reaction rn:R00825 http://www.genome.jp/dbget-bin/www_bget?rn:R00825 KEGG_Reaction rn:R02000 http://www.genome.jp/dbget-bin/www_bget?rn:R02000 KEGG_Reaction rn:R03543 http://www.genome.jp/dbget-bin/www_bget?rn:R03543 KEGG_Reaction rn:R03559 http://www.genome.jp/dbget-bin/www_bget?rn:R03559 KEGG_Reaction rn:R05247 http://www.genome.jp/dbget-bin/www_bget?rn:R05247 KEGG_Reaction rn:R05261 http://www.genome.jp/dbget-bin/www_bget?rn:R05261 KEGG_Reaction rn:R05262 http://www.genome.jp/dbget-bin/www_bget?rn:R05262 KEGG_Reaction rn:R05263 http://www.genome.jp/dbget-bin/www_bget?rn:R05263 KEGG_Reaction rn:R05264 http://www.genome.jp/dbget-bin/www_bget?rn:R05264 KEGG_Reaction rn:R05440 http://www.genome.jp/dbget-bin/www_bget?rn:R05440 KEGG_Reaction rn:R06782 http://www.genome.jp/dbget-bin/www_bget?rn:R06782 KEGG_Reaction rn:R06783 http://www.genome.jp/dbget-bin/www_bget?rn:R06783 KEGG_Reaction rn:R09151 http://www.genome.jp/dbget-bin/www_bget?rn:R09151 KEGG_Reaction rn:R09152 http://www.genome.jp/dbget-bin/www_bget?rn:R09152 OMA HAGFQVA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HAGFQVA PSORT swissprot:HCAD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HCAD_ECOLI PSORT-B swissprot:HCAD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HCAD_ECOLI PSORT2 swissprot:HCAD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HCAD_ECOLI Pfam PF07992 http://pfam.xfam.org/family/PF07992 Pfam PF14759 http://pfam.xfam.org/family/PF14759 Phobius swissprot:HCAD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HCAD_ECOLI PhylomeDB P77650 http://phylomedb.org/?seqid=P77650 ProteinModelPortal P77650 http://www.proteinmodelportal.org/query/uniprot/P77650 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9603882 http://www.ncbi.nlm.nih.gov/pubmed/9603882 RefSeq NP_417037 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417037 RefSeq WP_000660788 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000660788 SMR P77650 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77650 STRING 511145.b2542 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2542&targetmode=cogs STRING COG0446 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0446&targetmode=cogs SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 SUPFAM SSF55424 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55424 UniProtKB HCAD_ECOLI http://www.uniprot.org/uniprot/HCAD_ECOLI UniProtKB-AC P77650 http://www.uniprot.org/uniprot/P77650 charge swissprot:HCAD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HCAD_ECOLI eggNOG COG0446 http://eggnogapi.embl.de/nog_data/html/tree/COG0446 eggNOG ENOG4108EQM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108EQM epestfind swissprot:HCAD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HCAD_ECOLI garnier swissprot:HCAD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HCAD_ECOLI helixturnhelix swissprot:HCAD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HCAD_ECOLI hmoment swissprot:HCAD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HCAD_ECOLI iep swissprot:HCAD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HCAD_ECOLI inforesidue swissprot:HCAD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HCAD_ECOLI octanol swissprot:HCAD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HCAD_ECOLI pepcoil swissprot:HCAD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HCAD_ECOLI pepdigest swissprot:HCAD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HCAD_ECOLI pepinfo swissprot:HCAD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HCAD_ECOLI pepnet swissprot:HCAD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HCAD_ECOLI pepstats swissprot:HCAD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HCAD_ECOLI pepwheel swissprot:HCAD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HCAD_ECOLI pepwindow swissprot:HCAD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HCAD_ECOLI sigcleave swissprot:HCAD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HCAD_ECOLI ## Database ID URL or Descriptions # BioGrid 4261874 172 # EcoGene EG12810 yhcD # FUNCTION YHCD_ECOLI Involved in the export and assembly of a fimbrial subunit across the outer membrane. {ECO 0000250}. # GO_component GO:0009279 cell outer membrane; IBA:GO_Central. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015473 fimbrial usher porin activity; IBA:GO_Central. # GO_process GO:0009297 pilus assembly; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0022607 cellular component assembly # InterPro IPR000015 Fimb_usher # InterPro IPR018030 Fimbrial_membr_usher_CS # InterPro IPR025885 PapC_N # InterPro IPR025949 PapC-like_C # Organism YHCD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30451 PTHR30451 # PATRIC 32121854 VBIEscCol129921_3311 # PIR B65113 B65113 # PROSITE PS01151 FIMBRIAL_USHER # Pfam PF00577 Usher # Pfam PF13953 PapC_C # Pfam PF13954 PapC_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHCD_ECOLI Uncharacterized outer membrane usher protein YhcD # RefSeq NP_417683 NC_000913.3 # RefSeq WP_000914994 NZ_LN832404.1 # SIMILARITY Belongs to the fimbrial export usher family. {ECO 0000305}. # SUBCELLULAR LOCATION YHCD_ECOLI Cell outer membrane {ECO 0000250}; Multi- pass membrane protein {ECO 0000250}. # TCDB 1.B.11.5 the outer membrane fimbrial usher porin (fup) family # eggNOG ENOG4105E6S Bacteria # eggNOG ENOG410XPN5 LUCA BLAST swissprot:YHCD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHCD_ECOLI BioCyc ECOL316407:JW3183-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3183-MONOMER BioCyc EcoCyc:G7670-MONOMER http://biocyc.org/getid?id=EcoCyc:G7670-MONOMER DIP DIP-12277N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12277N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2661 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2661 EcoGene EG12810 http://www.ecogene.org/geneInfo.php?eg_id=EG12810 EnsemblBacteria AAC76248 http://www.ensemblgenomes.org/id/AAC76248 EnsemblBacteria AAC76248 http://www.ensemblgenomes.org/id/AAC76248 EnsemblBacteria BAE77260 http://www.ensemblgenomes.org/id/BAE77260 EnsemblBacteria BAE77260 http://www.ensemblgenomes.org/id/BAE77260 EnsemblBacteria BAE77260 http://www.ensemblgenomes.org/id/BAE77260 EnsemblBacteria b3216 http://www.ensemblgenomes.org/id/b3216 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015473 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015473 GO_process GO:0009297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009297 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GeneID 947738 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947738 HOGENOM HOG000260663 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260663&db=HOGENOM6 InterPro IPR000015 http://www.ebi.ac.uk/interpro/entry/IPR000015 InterPro IPR018030 http://www.ebi.ac.uk/interpro/entry/IPR018030 InterPro IPR025885 http://www.ebi.ac.uk/interpro/entry/IPR025885 InterPro IPR025949 http://www.ebi.ac.uk/interpro/entry/IPR025949 KEGG_Gene ecj:JW3183 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3183 KEGG_Gene eco:b3216 http://www.genome.jp/dbget-bin/www_bget?eco:b3216 OMA NASINWA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NASINWA PANTHER PTHR30451 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30451 PROSITE PS01151 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01151 PSORT swissprot:YHCD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHCD_ECOLI PSORT-B swissprot:YHCD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHCD_ECOLI PSORT2 swissprot:YHCD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHCD_ECOLI Pfam PF00577 http://pfam.xfam.org/family/PF00577 Pfam PF13953 http://pfam.xfam.org/family/PF13953 Pfam PF13954 http://pfam.xfam.org/family/PF13954 Phobius swissprot:YHCD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHCD_ECOLI PhylomeDB P45420 http://phylomedb.org/?seqid=P45420 ProteinModelPortal P45420 http://www.proteinmodelportal.org/query/uniprot/P45420 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417683 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417683 RefSeq WP_000914994 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000914994 SMR P45420 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45420 STRING 511145.b3216 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3216&targetmode=cogs TCDB 1.B.11.5 http://www.tcdb.org/search/result.php?tc=1.B.11.5 UniProtKB YHCD_ECOLI http://www.uniprot.org/uniprot/YHCD_ECOLI UniProtKB-AC P45420 http://www.uniprot.org/uniprot/P45420 charge swissprot:YHCD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHCD_ECOLI eggNOG ENOG4105E6S http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E6S eggNOG ENOG410XPN5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPN5 epestfind swissprot:YHCD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHCD_ECOLI garnier swissprot:YHCD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHCD_ECOLI helixturnhelix swissprot:YHCD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHCD_ECOLI hmoment swissprot:YHCD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHCD_ECOLI iep swissprot:YHCD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHCD_ECOLI inforesidue swissprot:YHCD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHCD_ECOLI octanol swissprot:YHCD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHCD_ECOLI pepcoil swissprot:YHCD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHCD_ECOLI pepdigest swissprot:YHCD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHCD_ECOLI pepinfo swissprot:YHCD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHCD_ECOLI pepnet swissprot:YHCD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHCD_ECOLI pepstats swissprot:YHCD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHCD_ECOLI pepwheel swissprot:YHCD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHCD_ECOLI pepwindow swissprot:YHCD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHCD_ECOLI sigcleave swissprot:YHCD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHCD_ECOLI ## Database ID URL or Descriptions # BioGrid 4261268 134 # EcoGene EG12228 yhiM # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR021240 DUF2776 # Organism YHIM_ECOLI Escherichia coli (strain K12) # PATRIC 32122430 VBIEscCol129921_3592 # PIR S47711 S47711 # Pfam PF10951 DUF2776 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHIM_ECOLI Inner membrane protein YhiM # RefSeq NP_417948 NC_000913.3 # SEQUENCE CAUTION Sequence=AAB18467.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SUBCELLULAR LOCATION YHIM_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG ENOG4107UNS Bacteria # eggNOG ENOG410ZE9J LUCA BLAST swissprot:YHIM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHIM_ECOLI BioCyc ECOL316407:JW5944-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5944-MONOMER BioCyc EcoCyc:MONOMER0-2489 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2489 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2140 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2140 EcoGene EG12228 http://www.ecogene.org/geneInfo.php?eg_id=EG12228 EnsemblBacteria AAC76516 http://www.ensemblgenomes.org/id/AAC76516 EnsemblBacteria AAC76516 http://www.ensemblgenomes.org/id/AAC76516 EnsemblBacteria BAE77803 http://www.ensemblgenomes.org/id/BAE77803 EnsemblBacteria BAE77803 http://www.ensemblgenomes.org/id/BAE77803 EnsemblBacteria BAE77803 http://www.ensemblgenomes.org/id/BAE77803 EnsemblBacteria b3491 http://www.ensemblgenomes.org/id/b3491 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 947997 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947997 HOGENOM HOG000125793 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125793&db=HOGENOM6 InParanoid P37630 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37630 InterPro IPR021240 http://www.ebi.ac.uk/interpro/entry/IPR021240 KEGG_Gene ecj:JW5944 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5944 KEGG_Gene eco:b3491 http://www.genome.jp/dbget-bin/www_bget?eco:b3491 PSORT swissprot:YHIM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHIM_ECOLI PSORT-B swissprot:YHIM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHIM_ECOLI PSORT2 swissprot:YHIM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHIM_ECOLI Pfam PF10951 http://pfam.xfam.org/family/PF10951 Phobius swissprot:YHIM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHIM_ECOLI ProteinModelPortal P37630 http://www.proteinmodelportal.org/query/uniprot/P37630 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417948 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417948 STRING 511145.b3491 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3491&targetmode=cogs UniProtKB YHIM_ECOLI http://www.uniprot.org/uniprot/YHIM_ECOLI UniProtKB-AC P37630 http://www.uniprot.org/uniprot/P37630 charge swissprot:YHIM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHIM_ECOLI eggNOG ENOG4107UNS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107UNS eggNOG ENOG410ZE9J http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZE9J epestfind swissprot:YHIM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHIM_ECOLI garnier swissprot:YHIM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHIM_ECOLI helixturnhelix swissprot:YHIM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHIM_ECOLI hmoment swissprot:YHIM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHIM_ECOLI iep swissprot:YHIM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHIM_ECOLI inforesidue swissprot:YHIM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHIM_ECOLI octanol swissprot:YHIM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHIM_ECOLI pepcoil swissprot:YHIM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHIM_ECOLI pepdigest swissprot:YHIM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHIM_ECOLI pepinfo swissprot:YHIM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHIM_ECOLI pepnet swissprot:YHIM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHIM_ECOLI pepstats swissprot:YHIM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHIM_ECOLI pepwheel swissprot:YHIM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHIM_ECOLI pepwindow swissprot:YHIM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHIM_ECOLI sigcleave swissprot:YHIM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHIM_ECOLI ## Database ID URL or Descriptions # BRENDA 4.2.1.46 2026 # BioGrid 4262077 235 # CATALYTIC ACTIVITY RMLB2_ECOLI dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy- alpha-D-glucose + H(2)O. {ECO 0000269|PubMed 11380254, ECO 0000269|PubMed 11601973, ECO 0000269|PubMed 7559340}. # CAUTION Was originally thought to be rffE, the UDP-N- acetylglucosamine epimerase. {ECO:0000305|PubMed 1379743}. # COFACTOR RMLB2_ECOLI Name=NAD(+); Xref=ChEBI CHEBI 57540; Evidence={ECO 0000269|Ref.8}; Note=Binds 1 NAD(+) per subunit. {ECO 0000269|Ref.8}; # EcoGene EG11453 rffG # FUNCTION RMLB2_ECOLI Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction. {ECO 0000269|PubMed 11380254, ECO 0000269|PubMed 11601973, ECO 0000269|PubMed 7559340}. # GO_function GO:0008460 dTDP-glucose 4,6-dehydratase activity; IDA:UniProtKB. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IDA:UniProtKB. # GO_process GO:0009225 nucleotide-sugar metabolic process; IEA:InterPro. # GO_process GO:0009246 enterobacterial common antigen biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0045226 extracellular polysaccharide biosynthetic process; IDA:UniProtKB. # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.50.720 -; 1. # InterPro IPR005888 dTDP_Gluc_deHydtase # InterPro IPR016040 NAD(P)-bd_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00521 Streptomycin biosynthesis # KEGG_Pathway ko00523 Polyketide sugar unit biosynthesis # KEGG_Pathway ko01055 Biosynthesis of vancomycin group antibiotics # Organism RMLB2_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10366:SF41 PTHR10366:SF41 # PATHWAY Bacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis. {ECO:0000269|PubMed 7559340}. # PATHWAY Nucleotide-sugar biosynthesis; dTDP-4-acetamido-4,6- dideoxygalactose biosynthesis. {ECO:0000269|PubMed 7559340}. # PATRIC 32123069 VBIEscCol129921_3904 # PDB 1BXK X-ray; 1.90 A; A/B=1-355 # PIR G65182 G65182 # Pfam PF16363 GDP_Man_Dehyd # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RMLB2_ECOLI dTDP-glucose 4,6-dehydratase 2 # RefSeq WP_001226601 NZ_LN832404.1 # RefSeq YP_026255 NC_000913.3 # SIMILARITY Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. {ECO 0000305}. # SUBUNIT Homodimer. {ECO 0000269|Ref.8}. # SUPFAM SSF51735 SSF51735 # TIGRFAMs TIGR01181 dTDP_gluc_dehyt # eggNOG COG1088 LUCA # eggNOG ENOG4105C1B Bacteria BLAST swissprot:RMLB2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RMLB2_ECOLI BioCyc ECOL316407:JW5598-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5598-MONOMER BioCyc EcoCyc:DTDPGLUCDEHYDRAT2-MONOMER http://biocyc.org/getid?id=EcoCyc:DTDPGLUCDEHYDRAT2-MONOMER BioCyc MetaCyc:DTDPGLUCDEHYDRAT2-MONOMER http://biocyc.org/getid?id=MetaCyc:DTDPGLUCDEHYDRAT2-MONOMER COG COG1088 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1088 DOI 10.1021/bi010441a http://dx.doi.org/10.1021/bi010441a DOI 10.1021/bi011138c http://dx.doi.org/10.1021/bi011138c DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.1.46 {ECO:0000269|PubMed:11380254, ECO:0000269|PubMed:11601973, ECO:0000269|PubMed:7559340} http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.46 {ECO:0000269|PubMed:11380254, ECO:0000269|PubMed:11601973, ECO:0000269|PubMed:7559340} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 4.2.1.46 {ECO:0000269|PubMed:11380254, ECO:0000269|PubMed:11601973, ECO:0000269|PubMed:7559340} http://enzyme.expasy.org/EC/4.2.1.46 {ECO:0000269|PubMed:11380254, ECO:0000269|PubMed:11601973, ECO:0000269|PubMed:7559340} EchoBASE EB1422 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1422 EcoGene EG11453 http://www.ecogene.org/geneInfo.php?eg_id=EG11453 EnsemblBacteria AAT48213 http://www.ensemblgenomes.org/id/AAT48213 EnsemblBacteria AAT48213 http://www.ensemblgenomes.org/id/AAT48213 EnsemblBacteria BAE77510 http://www.ensemblgenomes.org/id/BAE77510 EnsemblBacteria BAE77510 http://www.ensemblgenomes.org/id/BAE77510 EnsemblBacteria BAE77510 http://www.ensemblgenomes.org/id/BAE77510 EnsemblBacteria b3788 http://www.ensemblgenomes.org/id/b3788 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008460 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008460 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GO_process GO:0009225 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009225 GO_process GO:0009246 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009246 GO_process GO:0045226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045226 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 948300 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948300 HOGENOM HOG000168006 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000168006&db=HOGENOM6 InParanoid P27830 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P27830 IntEnz 4.2.1.46 {ECO:0000269|PubMed:11380254, ECO:0000269|PubMed:11601973, ECO:0000269|PubMed:7559340} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.46 {ECO:0000269|PubMed:11380254, ECO:0000269|PubMed:11601973, ECO:0000269|PubMed:7559340} InterPro IPR005888 http://www.ebi.ac.uk/interpro/entry/IPR005888 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5598 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5598 KEGG_Gene eco:b3788 http://www.genome.jp/dbget-bin/www_bget?eco:b3788 KEGG_Orthology KO:K01710 http://www.genome.jp/dbget-bin/www_bget?KO:K01710 KEGG_Pathway ko00521 http://www.genome.jp/kegg-bin/show_pathway?ko00521 KEGG_Pathway ko00523 http://www.genome.jp/kegg-bin/show_pathway?ko00523 KEGG_Pathway ko01055 http://www.genome.jp/kegg-bin/show_pathway?ko01055 KEGG_Reaction rn:R06513 http://www.genome.jp/dbget-bin/www_bget?rn:R06513 OMA REWIDRQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=REWIDRQ PANTHER PTHR10366:SF41 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10366:SF41 PDB 1BXK http://www.ebi.ac.uk/pdbe-srv/view/entry/1BXK PDBsum 1BXK http://www.ebi.ac.uk/pdbsum/1BXK PSORT swissprot:RMLB2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RMLB2_ECOLI PSORT-B swissprot:RMLB2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RMLB2_ECOLI PSORT2 swissprot:RMLB2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RMLB2_ECOLI Pfam PF16363 http://pfam.xfam.org/family/PF16363 Phobius swissprot:RMLB2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RMLB2_ECOLI PhylomeDB P27830 http://phylomedb.org/?seqid=P27830 ProteinModelPortal P27830 http://www.proteinmodelportal.org/query/uniprot/P27830 PubMed 11380254 http://www.ncbi.nlm.nih.gov/pubmed/11380254 PubMed 11601973 http://www.ncbi.nlm.nih.gov/pubmed/11601973 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7559340 http://www.ncbi.nlm.nih.gov/pubmed/7559340 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001226601 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001226601 RefSeq YP_026255 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026255 SMR P27830 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P27830 STRING 511145.b3788 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3788&targetmode=cogs STRING COG1088 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1088&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 TIGRFAMs TIGR01181 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01181 UniProtKB RMLB2_ECOLI http://www.uniprot.org/uniprot/RMLB2_ECOLI UniProtKB-AC P27830 http://www.uniprot.org/uniprot/P27830 charge swissprot:RMLB2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RMLB2_ECOLI eggNOG COG1088 http://eggnogapi.embl.de/nog_data/html/tree/COG1088 eggNOG ENOG4105C1B http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C1B epestfind swissprot:RMLB2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RMLB2_ECOLI garnier swissprot:RMLB2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RMLB2_ECOLI helixturnhelix swissprot:RMLB2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RMLB2_ECOLI hmoment swissprot:RMLB2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RMLB2_ECOLI iep swissprot:RMLB2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RMLB2_ECOLI inforesidue swissprot:RMLB2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RMLB2_ECOLI octanol swissprot:RMLB2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RMLB2_ECOLI pepcoil swissprot:RMLB2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RMLB2_ECOLI pepdigest swissprot:RMLB2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RMLB2_ECOLI pepinfo swissprot:RMLB2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RMLB2_ECOLI pepnet swissprot:RMLB2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RMLB2_ECOLI pepstats swissprot:RMLB2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RMLB2_ECOLI pepwheel swissprot:RMLB2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RMLB2_ECOLI pepwindow swissprot:RMLB2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RMLB2_ECOLI sigcleave swissprot:RMLB2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RMLB2_ECOLI ## Database ID URL or Descriptions # AltName MCBA_ECOLI MqsR-controlled colanic acid and biofilm protein A # BioGrid 4263330 7 # EcoGene EG13318 mcbA # FUNCTION MCBA_ECOLI Affects biofilm formation and mucoidy. {ECO 0000269|PubMed 18309357}. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_process GO:0009242 colanic acid biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.30.1660.10 -; 1. # INDUCTION MCBA_ECOLI Repressed by McbR. # InterPro IPR010854 DUF1471 # InterPro IPR025543 Dodecin-like # Organism MCBA_ECOLI Escherichia coli (strain K12) # PATRIC 32116815 VBIEscCol129921_0833 # PIR F64817 F64817 # Pfam PF07338 DUF1471 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MCBA_ECOLI Uncharacterized protein McbA # RefSeq NP_415327 NC_000913.3 # RefSeq WP_000710619 NZ_LN832404.1 # SIMILARITY Belongs to the BhsA/McbA family. {ECO 0000305}. # SUBCELLULAR LOCATION MCBA_ECOLI Periplasm {ECO 0000305}. # SUPFAM SSF159871 SSF159871 # eggNOG ENOG4105ZY9 Bacteria # eggNOG ENOG41122XF LUCA BLAST swissprot:MCBA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MCBA_ECOLI BioCyc ECOL316407:JW5106-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5106-MONOMER BioCyc EcoCyc:G6415-MONOMER http://biocyc.org/getid?id=EcoCyc:G6415-MONOMER DOI 10.1038/ismej.2008.24 http://dx.doi.org/10.1038/ismej.2008.24 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3102 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3102 EcoGene EG13318 http://www.ecogene.org/geneInfo.php?eg_id=EG13318 EnsemblBacteria AAC73893 http://www.ensemblgenomes.org/id/AAC73893 EnsemblBacteria AAC73893 http://www.ensemblgenomes.org/id/AAC73893 EnsemblBacteria BAA35472 http://www.ensemblgenomes.org/id/BAA35472 EnsemblBacteria BAA35472 http://www.ensemblgenomes.org/id/BAA35472 EnsemblBacteria BAA35472 http://www.ensemblgenomes.org/id/BAA35472 EnsemblBacteria b0806 http://www.ensemblgenomes.org/id/b0806 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_process GO:0009242 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009242 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.30.1660.10 http://www.cathdb.info/version/latest/superfamily/3.30.1660.10 GeneID 947523 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947523 HOGENOM HOG000117400 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117400&db=HOGENOM6 InterPro IPR010854 http://www.ebi.ac.uk/interpro/entry/IPR010854 InterPro IPR025543 http://www.ebi.ac.uk/interpro/entry/IPR025543 KEGG_Gene ecj:JW5106 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5106 KEGG_Gene eco:b0806 http://www.genome.jp/dbget-bin/www_bget?eco:b0806 KEGG_Orthology KO:K13650 http://www.genome.jp/dbget-bin/www_bget?KO:K13650 OMA YGTATIY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YGTATIY PSORT swissprot:MCBA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MCBA_ECOLI PSORT-B swissprot:MCBA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MCBA_ECOLI PSORT2 swissprot:MCBA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MCBA_ECOLI Pfam PF07338 http://pfam.xfam.org/family/PF07338 Phobius swissprot:MCBA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MCBA_ECOLI PhylomeDB P0AAX6 http://phylomedb.org/?seqid=P0AAX6 ProteinModelPortal P0AAX6 http://www.proteinmodelportal.org/query/uniprot/P0AAX6 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18309357 http://www.ncbi.nlm.nih.gov/pubmed/18309357 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415327 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415327 RefSeq WP_000710619 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000710619 SMR P0AAX6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAX6 STRING 511145.b0806 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0806&targetmode=cogs SUPFAM SSF159871 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF159871 UniProtKB MCBA_ECOLI http://www.uniprot.org/uniprot/MCBA_ECOLI UniProtKB-AC P0AAX6 http://www.uniprot.org/uniprot/P0AAX6 charge swissprot:MCBA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MCBA_ECOLI eggNOG ENOG4105ZY9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ZY9 eggNOG ENOG41122XF http://eggnogapi.embl.de/nog_data/html/tree/ENOG41122XF epestfind swissprot:MCBA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MCBA_ECOLI garnier swissprot:MCBA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MCBA_ECOLI helixturnhelix swissprot:MCBA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MCBA_ECOLI hmoment swissprot:MCBA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MCBA_ECOLI iep swissprot:MCBA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MCBA_ECOLI inforesidue swissprot:MCBA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MCBA_ECOLI octanol swissprot:MCBA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MCBA_ECOLI pepcoil swissprot:MCBA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MCBA_ECOLI pepdigest swissprot:MCBA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MCBA_ECOLI pepinfo swissprot:MCBA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MCBA_ECOLI pepnet swissprot:MCBA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MCBA_ECOLI pepstats swissprot:MCBA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MCBA_ECOLI pepwheel swissprot:MCBA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MCBA_ECOLI pepwindow swissprot:MCBA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MCBA_ECOLI sigcleave swissprot:MCBA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MCBA_ECOLI ## Database ID URL or Descriptions # AltName YDCD_ECOLI ORF-E2 # BioGrid 4262887 2 # EcoGene EG11760 ydcD # IntAct P31991 2 # Organism YDCD_ECOLI Escherichia coli (strain K12) # PATRIC 32118208 VBIEscCol129921_1524 # PIR D64898 D64898 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDCD_ECOLI Uncharacterized protein YdcD # RefSeq NP_415974 NC_000913.3 # RefSeq WP_000939263 NZ_LN832404.1 BLAST swissprot:YDCD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDCD_ECOLI BioCyc ECOL316407:JW1452-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1452-MONOMER BioCyc EcoCyc:EG11760-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11760-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X60998 http://www.ebi.ac.uk/ena/data/view/X60998 EchoBASE EB1710 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1710 EcoGene EG11760 http://www.ecogene.org/geneInfo.php?eg_id=EG11760 EnsemblBacteria AAC74539 http://www.ensemblgenomes.org/id/AAC74539 EnsemblBacteria AAC74539 http://www.ensemblgenomes.org/id/AAC74539 EnsemblBacteria BAA15088 http://www.ensemblgenomes.org/id/BAA15088 EnsemblBacteria BAA15088 http://www.ensemblgenomes.org/id/BAA15088 EnsemblBacteria BAA15088 http://www.ensemblgenomes.org/id/BAA15088 EnsemblBacteria b1457 http://www.ensemblgenomes.org/id/b1457 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946958 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946958 HOGENOM HOG000009332 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009332&db=HOGENOM6 IntAct P31991 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31991* KEGG_Gene ecj:JW1452 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1452 KEGG_Gene eco:b1457 http://www.genome.jp/dbget-bin/www_bget?eco:b1457 PSORT swissprot:YDCD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDCD_ECOLI PSORT-B swissprot:YDCD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDCD_ECOLI PSORT2 swissprot:YDCD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDCD_ECOLI Phobius swissprot:YDCD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDCD_ECOLI ProteinModelPortal P31991 http://www.proteinmodelportal.org/query/uniprot/P31991 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8387990 http://www.ncbi.nlm.nih.gov/pubmed/8387990 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415974 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415974 RefSeq WP_000939263 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000939263 STRING 511145.b1457 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1457&targetmode=cogs UniProtKB YDCD_ECOLI http://www.uniprot.org/uniprot/YDCD_ECOLI UniProtKB-AC P31991 http://www.uniprot.org/uniprot/P31991 charge swissprot:YDCD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDCD_ECOLI epestfind swissprot:YDCD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDCD_ECOLI garnier swissprot:YDCD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDCD_ECOLI helixturnhelix swissprot:YDCD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDCD_ECOLI hmoment swissprot:YDCD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDCD_ECOLI iep swissprot:YDCD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDCD_ECOLI inforesidue swissprot:YDCD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDCD_ECOLI octanol swissprot:YDCD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDCD_ECOLI pepcoil swissprot:YDCD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDCD_ECOLI pepdigest swissprot:YDCD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDCD_ECOLI pepinfo swissprot:YDCD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDCD_ECOLI pepnet swissprot:YDCD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDCD_ECOLI pepstats swissprot:YDCD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDCD_ECOLI pepwheel swissprot:YDCD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDCD_ECOLI pepwindow swissprot:YDCD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDCD_ECOLI sigcleave swissprot:YDCD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDCD_ECOLI ## Database ID URL or Descriptions # BioGrid 4260764 9 # CDD cd00530 PTE # COFACTOR PHP_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 9548740}; Note=Binds 2 Zn(2+) ions per subunit. {ECO 0000269|PubMed 9548740}; # EcoGene EG12917 php # FUNCTION PHP_ECOLI Its real enzymatic activity is not yet known. It was tested for general esterase, aminopeptidase, sulfatase, phosphatase, carbonic anhydrase, phosphodiesterase, and phosphotriesterase activities with the following substrates p- nitrophenyl acetate, L-alanine nitroanilide, p-nitrophenyl sulfate, bis(p-nitrophenyl) phosphate, paraoxon, and p-nitrophenyl phosphate. No enzymatic activity was detected with any of these non-specific substrates. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_function GO:0016788 hydrolase activity, acting on ester bonds; IEA:InterPro. # GO_process GO:0009056 catabolic process; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # IntAct P45548 2 # InterPro IPR001559 Phosphotriesterase # InterPro IPR017947 AryldialkylPase_Zn-BS # InterPro IPR032466 Metal_Hydrolase # Organism PHP_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10819 PTHR10819 # PATRIC 32122190 VBIEscCol129921_3472 # PDB 1BF6 X-ray; 1.70 A; A/B=2-292 # PDB 4LEF X-ray; 1.84 A; A/B/C/D/E/F/G/H=1-292 # PIR F65132 F65132 # PROSITE PS01322 PHOSPHOTRIESTERASE_1 # PROSITE PS51347 PHOSPHOTRIESTERASE_2 # Pfam PF02126 PTE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PHP_ECOLI Phosphotriesterase homology protein # RefSeq NP_417838 NC_000913.3 # RefSeq WP_000007010 NZ_LN832404.1 # SIMILARITY Belongs to the phosphotriesterase family. {ECO:0000255|PROSITE-ProRule PRU00679}. # SUBUNIT PHP_ECOLI Monomer. # SUPFAM SSF51556 SSF51556 # eggNOG COG1735 LUCA # eggNOG ENOG41080QX Bacteria BLAST swissprot:PHP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PHP_ECOLI BioCyc ECOL316407:JW3342-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3342-MONOMER BioCyc EcoCyc:G7731-MONOMER http://biocyc.org/getid?id=EcoCyc:G7731-MONOMER COG COG1735 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1735 DIP DIP-10504N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10504N DOI 10.1021/bi971707+ http://dx.doi.org/10.1021/bi971707+ DOI 10.1021/bi985043v http://dx.doi.org/10.1021/bi985043v DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2753 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2753 EcoGene EG12917 http://www.ecogene.org/geneInfo.php?eg_id=EG12917 EnsemblBacteria AAC76404 http://www.ensemblgenomes.org/id/AAC76404 EnsemblBacteria AAC76404 http://www.ensemblgenomes.org/id/AAC76404 EnsemblBacteria BAE77912 http://www.ensemblgenomes.org/id/BAE77912 EnsemblBacteria BAE77912 http://www.ensemblgenomes.org/id/BAE77912 EnsemblBacteria BAE77912 http://www.ensemblgenomes.org/id/BAE77912 EnsemblBacteria b3379 http://www.ensemblgenomes.org/id/b3379 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0016788 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016788 GO_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GeneID 947891 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947891 HOGENOM HOG000081700 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000081700&db=HOGENOM6 InParanoid P45548 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45548 IntAct P45548 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45548* InterPro IPR001559 http://www.ebi.ac.uk/interpro/entry/IPR001559 InterPro IPR017947 http://www.ebi.ac.uk/interpro/entry/IPR017947 InterPro IPR032466 http://www.ebi.ac.uk/interpro/entry/IPR032466 KEGG_Gene ecj:JW3342 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3342 KEGG_Gene eco:b3379 http://www.genome.jp/dbget-bin/www_bget?eco:b3379 KEGG_Orthology KO:K07048 http://www.genome.jp/dbget-bin/www_bget?KO:K07048 OMA CDAHDHL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CDAHDHL PANTHER PTHR10819 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10819 PDB 1BF6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1BF6 PDB 4LEF http://www.ebi.ac.uk/pdbe-srv/view/entry/4LEF PDBsum 1BF6 http://www.ebi.ac.uk/pdbsum/1BF6 PDBsum 4LEF http://www.ebi.ac.uk/pdbsum/4LEF PROSITE PS01322 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01322 PROSITE PS51347 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51347 PSORT swissprot:PHP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PHP_ECOLI PSORT-B swissprot:PHP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PHP_ECOLI PSORT2 swissprot:PHP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PHP_ECOLI Pfam PF02126 http://pfam.xfam.org/family/PF02126 Phobius swissprot:PHP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PHP_ECOLI PhylomeDB P45548 http://phylomedb.org/?seqid=P45548 ProteinModelPortal P45548 http://www.proteinmodelportal.org/query/uniprot/P45548 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9548740 http://www.ncbi.nlm.nih.gov/pubmed/9548740 PubMed 9692977 http://www.ncbi.nlm.nih.gov/pubmed/9692977 RefSeq NP_417838 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417838 RefSeq WP_000007010 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000007010 SMR P45548 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45548 STRING 511145.b3379 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3379&targetmode=cogs STRING COG1735 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1735&targetmode=cogs SUPFAM SSF51556 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51556 UniProtKB PHP_ECOLI http://www.uniprot.org/uniprot/PHP_ECOLI UniProtKB-AC P45548 http://www.uniprot.org/uniprot/P45548 charge swissprot:PHP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PHP_ECOLI eggNOG COG1735 http://eggnogapi.embl.de/nog_data/html/tree/COG1735 eggNOG ENOG41080QX http://eggnogapi.embl.de/nog_data/html/tree/ENOG41080QX epestfind swissprot:PHP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PHP_ECOLI garnier swissprot:PHP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PHP_ECOLI helixturnhelix swissprot:PHP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PHP_ECOLI hmoment swissprot:PHP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PHP_ECOLI iep swissprot:PHP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PHP_ECOLI inforesidue swissprot:PHP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PHP_ECOLI octanol swissprot:PHP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PHP_ECOLI pepcoil swissprot:PHP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PHP_ECOLI pepdigest swissprot:PHP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PHP_ECOLI pepinfo swissprot:PHP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PHP_ECOLI pepnet swissprot:PHP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PHP_ECOLI pepstats swissprot:PHP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PHP_ECOLI pepwheel swissprot:PHP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PHP_ECOLI pepwindow swissprot:PHP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PHP_ECOLI sigcleave swissprot:PHP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PHP_ECOLI ## Database ID URL or Descriptions # BioGrid 4262380 12 # CATALYTIC ACTIVITY YQHD_ECOLI An alcohol + NADP(+) = an aldehyde + NADPH. # COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI 29105; Note=Binds 1 zinc ion per subunit.; # EcoGene EG13014 yqhD # FUNCTION YQHD_ECOLI NADP-dependent ADH activity. {ECO 0000269|PubMed 15327949}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008106 alcohol dehydrogenase (NADP+) activity; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_function GO:0018455 alcohol dehydrogenase [NAD(P)+] activity; IDA:EcoliWiki. # GO_function GO:0033721 aldehyde dehydrogenase (NADP+) activity; IDA:EcoCyc. # GO_function GO:1990002 methylglyoxal reductase (NADPH-dependent, acetol producing); IDA:EcoCyc. # GO_process GO:0000302 response to reactive oxygen species; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # IntAct Q46856 3 # InterPro IPR001670 ADH_Fe # InterPro IPR018211 ADH_Fe_CS # KEGG_Brite ko01000 Enzymes # Organism YQHD_ECOLI Escherichia coli (strain K12) # PATRIC 32121438 VBIEscCol129921_3106 # PDB 1OJ7 X-ray; 2.00 A; A/B/C/D=2-387 # PDB 4QGS X-ray; 1.70 A; A=1-387 # PIR A65088 A65088 # PROSITE PS00060 ADH_IRON_2 # PROSITE PS00913 ADH_IRON_1 # Pfam PF00465 Fe-ADH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQHD_ECOLI Alcohol dehydrogenase YqhD # RefSeq NP_417484 NC_000913.3 # RefSeq WP_001058802 NZ_LN832404.1 # SIMILARITY Belongs to the iron-containing alcohol dehydrogenase family. {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 15327949}. # eggNOG COG1979 LUCA # eggNOG ENOG4108I6A Bacteria BLAST swissprot:YQHD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQHD_ECOLI BioCyc ECOL316407:JW2978-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2978-MONOMER BioCyc EcoCyc:G7564-MONOMER http://biocyc.org/getid?id=EcoCyc:G7564-MONOMER BioCyc MetaCyc:G7564-MONOMER http://biocyc.org/getid?id=MetaCyc:G7564-MONOMER COG COG1979 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1979 DIP DIP-12870N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12870N DOI 10.1016/j.jmb.2004.07.034 http://dx.doi.org/10.1016/j.jmb.2004.07.034 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.- http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 ENZYME 1.1.1.- http://enzyme.expasy.org/EC/1.1.1.- EchoBASE EB2834 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2834 EcoGene EG13014 http://www.ecogene.org/geneInfo.php?eg_id=EG13014 EnsemblBacteria AAC76047 http://www.ensemblgenomes.org/id/AAC76047 EnsemblBacteria AAC76047 http://www.ensemblgenomes.org/id/AAC76047 EnsemblBacteria BAE77068 http://www.ensemblgenomes.org/id/BAE77068 EnsemblBacteria BAE77068 http://www.ensemblgenomes.org/id/BAE77068 EnsemblBacteria BAE77068 http://www.ensemblgenomes.org/id/BAE77068 EnsemblBacteria b3011 http://www.ensemblgenomes.org/id/b3011 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008106 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008106 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0018455 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018455 GO_function GO:0033721 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033721 GO_function GO:1990002 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990002 GO_process GO:0000302 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000302 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 947493 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947493 HOGENOM HOG000243334 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000243334&db=HOGENOM6 InParanoid Q46856 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46856 IntAct Q46856 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46856* IntEnz 1.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1 InterPro IPR001670 http://www.ebi.ac.uk/interpro/entry/IPR001670 InterPro IPR018211 http://www.ebi.ac.uk/interpro/entry/IPR018211 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2978 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2978 KEGG_Gene eco:b3011 http://www.genome.jp/dbget-bin/www_bget?eco:b3011 KEGG_Orthology KO:K08325 http://www.genome.jp/dbget-bin/www_bget?KO:K08325 OMA SYETLMN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SYETLMN PDB 1OJ7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1OJ7 PDB 4QGS http://www.ebi.ac.uk/pdbe-srv/view/entry/4QGS PDBsum 1OJ7 http://www.ebi.ac.uk/pdbsum/1OJ7 PDBsum 4QGS http://www.ebi.ac.uk/pdbsum/4QGS PROSITE PS00060 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00060 PROSITE PS00913 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00913 PSORT swissprot:YQHD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQHD_ECOLI PSORT-B swissprot:YQHD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQHD_ECOLI PSORT2 swissprot:YQHD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQHD_ECOLI Pfam PF00465 http://pfam.xfam.org/family/PF00465 Phobius swissprot:YQHD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQHD_ECOLI PhylomeDB Q46856 http://phylomedb.org/?seqid=Q46856 ProteinModelPortal Q46856 http://www.proteinmodelportal.org/query/uniprot/Q46856 PubMed 15327949 http://www.ncbi.nlm.nih.gov/pubmed/15327949 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417484 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417484 RefSeq WP_001058802 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001058802 SMR Q46856 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46856 STRING 511145.b3011 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3011&targetmode=cogs STRING COG1979 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1979&targetmode=cogs UniProtKB YQHD_ECOLI http://www.uniprot.org/uniprot/YQHD_ECOLI UniProtKB-AC Q46856 http://www.uniprot.org/uniprot/Q46856 charge swissprot:YQHD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQHD_ECOLI eggNOG COG1979 http://eggnogapi.embl.de/nog_data/html/tree/COG1979 eggNOG ENOG4108I6A http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108I6A epestfind swissprot:YQHD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQHD_ECOLI garnier swissprot:YQHD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQHD_ECOLI helixturnhelix swissprot:YQHD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQHD_ECOLI hmoment swissprot:YQHD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQHD_ECOLI iep swissprot:YQHD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQHD_ECOLI inforesidue swissprot:YQHD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQHD_ECOLI octanol swissprot:YQHD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQHD_ECOLI pepcoil swissprot:YQHD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQHD_ECOLI pepdigest swissprot:YQHD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQHD_ECOLI pepinfo swissprot:YQHD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQHD_ECOLI pepnet swissprot:YQHD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQHD_ECOLI pepstats swissprot:YQHD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQHD_ECOLI pepwheel swissprot:YQHD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQHD_ECOLI pepwindow swissprot:YQHD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQHD_ECOLI sigcleave swissprot:YQHD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQHD_ECOLI ## Database ID URL or Descriptions # BioGrid 4263380 11 # EcoGene EG11159 argO # FUNCTION ARGO_ECOLI Involved in the export of arginine. Important to control the intracellular level of arginine and the correct balance between arginine and lysine. May also be involved in the export of canavanine (a plant-derived antimetabolite). {ECO 0000269|PubMed 15150242}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; ISM:EcoCyc. # GO_function GO:0015181 arginine transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0015809 arginine transport; IEA:InterPro. # GO_process GO:1902023 L-arginine transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # HAMAP MF_01901 ArgO # INDUCTION ARGO_ECOLI Transcriptionally regulated by ArgP in response to the accumulation of intracellular arginine or canavanine. Lysine has a negative effect on the expression of argO. # InterPro IPR001123 LysE-type # InterPro IPR004777 Lys/arg_exporter # InterPro IPR023445 Arg_export_ArgO_enterobac # KEGG_Brite ko02000 Transporters # Organism ARGO_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30086 PTHR30086 # PATRIC 32121260 VBIEscCol129921_3018 # PIR B65077 QQEC5A # Pfam PF01810 LysE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ARGO_ECOLI Arginine exporter protein ArgO # RefSeq NP_417398 NC_000913.3 # SIMILARITY Belongs to the LysE/ArgO transporter (TC 2.A.75) family. {ECO 0000305}. # SUBCELLULAR LOCATION ARGO_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.75.1 the l-lysine exporter (lyse) family # TIGRFAMs TIGR00948 2a75 # eggNOG COG1279 LUCA # eggNOG ENOG4108ZUB Bacteria BLAST swissprot:ARGO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARGO_ECOLI BioCyc ECOL316407:JW2890-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2890-MONOMER BioCyc EcoCyc:YGGA-MONOMER http://biocyc.org/getid?id=EcoCyc:YGGA-MONOMER BioCyc MetaCyc:YGGA-MONOMER http://biocyc.org/getid?id=MetaCyc:YGGA-MONOMER COG COG1279 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1279 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1989.tb00221.x http://dx.doi.org/10.1111/j.1365-2958.1989.tb00221.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.186.11.3539-3546.2004 http://dx.doi.org/10.1128/JB.186.11.3539-3546.2004 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EMBL X14436 http://www.ebi.ac.uk/ena/data/view/X14436 EchoBASE EB1148 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1148 EcoGene EG11159 http://www.ecogene.org/geneInfo.php?eg_id=EG11159 EnsemblBacteria AAC75960 http://www.ensemblgenomes.org/id/AAC75960 EnsemblBacteria AAC75960 http://www.ensemblgenomes.org/id/AAC75960 EnsemblBacteria BAE76987 http://www.ensemblgenomes.org/id/BAE76987 EnsemblBacteria BAE76987 http://www.ensemblgenomes.org/id/BAE76987 EnsemblBacteria BAE76987 http://www.ensemblgenomes.org/id/BAE76987 EnsemblBacteria b2923 http://www.ensemblgenomes.org/id/b2923 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015181 GO_process GO:0015809 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015809 GO_process GO:1902023 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902023 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 947418 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947418 HAMAP MF_01901 http://hamap.expasy.org/unirule/MF_01901 HOGENOM HOG000122948 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122948&db=HOGENOM6 InParanoid P11667 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P11667 InterPro IPR001123 http://www.ebi.ac.uk/interpro/entry/IPR001123 InterPro IPR004777 http://www.ebi.ac.uk/interpro/entry/IPR004777 InterPro IPR023445 http://www.ebi.ac.uk/interpro/entry/IPR023445 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2890 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2890 KEGG_Gene eco:b2923 http://www.genome.jp/dbget-bin/www_bget?eco:b2923 KEGG_Orthology KO:K06895 http://www.genome.jp/dbget-bin/www_bget?KO:K06895 OMA VQKFVFL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VQKFVFL PANTHER PTHR30086 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30086 PSORT swissprot:ARGO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARGO_ECOLI PSORT-B swissprot:ARGO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARGO_ECOLI PSORT2 swissprot:ARGO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARGO_ECOLI Pfam PF01810 http://pfam.xfam.org/family/PF01810 Phobius swissprot:ARGO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARGO_ECOLI PhylomeDB P11667 http://phylomedb.org/?seqid=P11667 ProteinModelPortal P11667 http://www.proteinmodelportal.org/query/uniprot/P11667 PubMed 15150242 http://www.ncbi.nlm.nih.gov/pubmed/15150242 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2546007 http://www.ncbi.nlm.nih.gov/pubmed/2546007 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417398 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417398 STRING 511145.b2923 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2923&targetmode=cogs STRING COG1279 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1279&targetmode=cogs TCDB 2.A.75.1 http://www.tcdb.org/search/result.php?tc=2.A.75.1 TIGRFAMs TIGR00948 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00948 UniProtKB ARGO_ECOLI http://www.uniprot.org/uniprot/ARGO_ECOLI UniProtKB-AC P11667 http://www.uniprot.org/uniprot/P11667 charge swissprot:ARGO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARGO_ECOLI eggNOG COG1279 http://eggnogapi.embl.de/nog_data/html/tree/COG1279 eggNOG ENOG4108ZUB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZUB epestfind swissprot:ARGO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARGO_ECOLI garnier swissprot:ARGO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARGO_ECOLI helixturnhelix swissprot:ARGO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARGO_ECOLI hmoment swissprot:ARGO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARGO_ECOLI iep swissprot:ARGO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARGO_ECOLI inforesidue swissprot:ARGO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARGO_ECOLI octanol swissprot:ARGO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARGO_ECOLI pepcoil swissprot:ARGO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARGO_ECOLI pepdigest swissprot:ARGO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARGO_ECOLI pepinfo swissprot:ARGO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARGO_ECOLI pepnet swissprot:ARGO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARGO_ECOLI pepstats swissprot:ARGO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARGO_ECOLI pepwheel swissprot:ARGO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARGO_ECOLI pepwindow swissprot:ARGO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARGO_ECOLI sigcleave swissprot:ARGO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARGO_ECOLI ## Database ID URL or Descriptions # EcoGene EG40008 insH10 # FUNCTION INH10_ECOLI Involved in the transposition of the insertion sequence IS5. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # InterPro IPR002559 Transposase_11 # InterPro IPR008490 Transposase_InsH_N # Organism INH10_ECOLI Escherichia coli (strain K12) # Pfam PF01609 DDE_Tnp_1 # Pfam PF05598 DUF772 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INH10_ECOLI Transposase InsH for insertion sequence element IS5R # RefSeq NP_414793 NC_000913.3 # RefSeq NP_415084 NC_000913.3 # RefSeq NP_415189 NC_000913.3 # RefSeq NP_415847 NC_000913.3 # RefSeq NP_416535 NC_000913.3 # RefSeq NP_416696 NC_000913.3 # RefSeq NP_417456 NC_000913.3 # RefSeq NP_417685 NC_000913.3 # RefSeq NP_417962 NC_000913.3 # SIMILARITY Belongs to the transposase 11 family. {ECO 0000305}. # eggNOG COG3039 LUCA # eggNOG ENOG4105F2I Bacteria BLAST swissprot:INH10_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INH10_ECOLI BioCyc EcoCyc:MONOMER0-4240 http://biocyc.org/getid?id=EcoCyc:MONOMER0-4240 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EcoGene EG40008 http://www.ecogene.org/geneInfo.php?eg_id=EG40008 EnsemblBacteria AAC76250 http://www.ensemblgenomes.org/id/AAC76250 EnsemblBacteria AAC76250 http://www.ensemblgenomes.org/id/AAC76250 EnsemblBacteria BAE77261 http://www.ensemblgenomes.org/id/BAE77261 EnsemblBacteria BAE77261 http://www.ensemblgenomes.org/id/BAE77261 EnsemblBacteria BAE77261 http://www.ensemblgenomes.org/id/BAE77261 EnsemblBacteria b3218 http://www.ensemblgenomes.org/id/b3218 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GeneID 944917 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944917 GeneID 944941 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944941 GeneID 945896 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945896 GeneID 946163 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946163 GeneID 946577 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946577 GeneID 947516 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947516 GeneID 947743 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947743 GeneID 948015 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948015 GeneID 949121 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949121 InParanoid P0CE57 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CE57 InterPro IPR002559 http://www.ebi.ac.uk/interpro/entry/IPR002559 InterPro IPR008490 http://www.ebi.ac.uk/interpro/entry/IPR008490 KEGG_Gene ecj:JW3185 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3185 KEGG_Gene eco:b0259 http://www.genome.jp/dbget-bin/www_bget?eco:b0259 KEGG_Gene eco:b0552 http://www.genome.jp/dbget-bin/www_bget?eco:b0552 KEGG_Gene eco:b0656 http://www.genome.jp/dbget-bin/www_bget?eco:b0656 KEGG_Gene eco:b1331 http://www.genome.jp/dbget-bin/www_bget?eco:b1331 KEGG_Gene eco:b2030 http://www.genome.jp/dbget-bin/www_bget?eco:b2030 KEGG_Gene eco:b2192 http://www.genome.jp/dbget-bin/www_bget?eco:b2192 KEGG_Gene eco:b2982 http://www.genome.jp/dbget-bin/www_bget?eco:b2982 KEGG_Gene eco:b3218 http://www.genome.jp/dbget-bin/www_bget?eco:b3218 KEGG_Gene eco:b3505 http://www.genome.jp/dbget-bin/www_bget?eco:b3505 PSORT swissprot:INH10_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INH10_ECOLI PSORT-B swissprot:INH10_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INH10_ECOLI PSORT2 swissprot:INH10_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INH10_ECOLI Pfam PF01609 http://pfam.xfam.org/family/PF01609 Pfam PF05598 http://pfam.xfam.org/family/PF05598 Phobius swissprot:INH10_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INH10_ECOLI PhylomeDB P0CE57 http://phylomedb.org/?seqid=P0CE57 ProteinModelPortal P0CE57 http://www.proteinmodelportal.org/query/uniprot/P0CE57 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414793 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414793 RefSeq NP_415084 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415084 RefSeq NP_415189 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415189 RefSeq NP_415847 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415847 RefSeq NP_416535 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416535 RefSeq NP_416696 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416696 RefSeq NP_417456 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417456 RefSeq NP_417685 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417685 RefSeq NP_417962 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417962 SMR P0CE57 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0CE57 STRING 511145.b3505 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3505&targetmode=cogs UniProtKB INH10_ECOLI http://www.uniprot.org/uniprot/INH10_ECOLI UniProtKB-AC P0CE57 http://www.uniprot.org/uniprot/P0CE57 charge swissprot:INH10_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INH10_ECOLI eggNOG COG3039 http://eggnogapi.embl.de/nog_data/html/tree/COG3039 eggNOG ENOG4105F2I http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F2I epestfind swissprot:INH10_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INH10_ECOLI garnier swissprot:INH10_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INH10_ECOLI helixturnhelix swissprot:INH10_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INH10_ECOLI hmoment swissprot:INH10_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INH10_ECOLI iep swissprot:INH10_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INH10_ECOLI inforesidue swissprot:INH10_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INH10_ECOLI octanol swissprot:INH10_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INH10_ECOLI pepcoil swissprot:INH10_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INH10_ECOLI pepdigest swissprot:INH10_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INH10_ECOLI pepinfo swissprot:INH10_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INH10_ECOLI pepnet swissprot:INH10_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INH10_ECOLI pepstats swissprot:INH10_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INH10_ECOLI pepwheel swissprot:INH10_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INH10_ECOLI pepwindow swissprot:INH10_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INH10_ECOLI sigcleave swissprot:INH10_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INH10_ECOLI ## Database ID URL or Descriptions # AltName NADD_ECOLI Deamido-NAD(+) diphosphorylase # AltName NADD_ECOLI Deamido-NAD(+) pyrophosphorylase # AltName NADD_ECOLI Nicotinate mononucleotide adenylyltransferase # BRENDA 2.7.7 2026 # BRENDA 2.7.7.18 2026 # CATALYTIC ACTIVITY NADD_ECOLI ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD(+). # ENZYME REGULATION NADD_ECOLI Activity is susceptible to product inhibition. # EcoGene EG13241 nadD # FUNCTION NADD_ECOLI Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). # GO_function GO:0000309 nicotinamide-nucleotide adenylyltransferase activity; IBA:GO_Central. # GO_function GO:0004515 nicotinate-nucleotide adenylyltransferase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0034355 NAD salvage; IMP:EcoCyc. # GO_process GO:0034628 'de novo' NAD biosynthetic process from aspartate; IMP:EcoCyc. # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.620 -; 1. # HAMAP MF_00244 NaMN_adenylyltr # IntAct P0A752 7 # InterPro IPR004821 Cyt_trans-like # InterPro IPR005248 NAMN_adtrnsfrase # InterPro IPR014729 Rossmann-like_a/b/a_fold # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00760 Nicotinate and nicotinamide metabolism # Organism NADD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR12039 PTHR12039 # PATHWAY Cofactor biosynthesis; NAD(+) biosynthesis; deamido- NAD(+) from nicotinate D-ribonucleotide step 1/1. # PATRIC 32116461 VBIEscCol129921_0670 # PDB 1K4K X-ray; 2.00 A; A/B/C/D=1-213 # PDB 1K4M X-ray; 1.90 A; A/B/C=1-213 # PIR E64798 E64798 # Pfam PF01467 CTP_transf_like # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NADD_ECOLI Nicotinate-nucleotide adenylyltransferase # RefSeq NP_415172 NC_000913.3 # RefSeq WP_000838889 NZ_LN832404.1 # SIMILARITY Belongs to the NadD family. {ECO 0000305}. # TIGRFAMs TIGR00125 cyt_tran_rel # TIGRFAMs TIGR00482 TIGR00482 # UniPathway UPA00253 UER00332 # eggNOG COG1057 LUCA # eggNOG ENOG4108Z1W Bacteria BLAST swissprot:NADD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NADD_ECOLI BioCyc ECOL316407:JW0634-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0634-MONOMER BioCyc EcoCyc:NICONUCADENYLYLTRAN-MONOMER http://biocyc.org/getid?id=EcoCyc:NICONUCADENYLYLTRAN-MONOMER BioCyc MetaCyc:NICONUCADENYLYLTRAN-MONOMER http://biocyc.org/getid?id=MetaCyc:NICONUCADENYLYLTRAN-MONOMER COG COG1057 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1057 DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1016/S0969-2126(01)00693-1 http://dx.doi.org/10.1016/S0969-2126(01)00693-1 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.15.4372-4374.2000 http://dx.doi.org/10.1128/JB.182.15.4372-4374.2000 EC_number EC:2.7.7.18 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.18 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U23163 http://www.ebi.ac.uk/ena/data/view/U23163 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 ENZYME 2.7.7.18 http://enzyme.expasy.org/EC/2.7.7.18 EchoBASE EB3030 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3030 EcoGene EG13241 http://www.ecogene.org/geneInfo.php?eg_id=EG13241 EnsemblBacteria AAC73740 http://www.ensemblgenomes.org/id/AAC73740 EnsemblBacteria AAC73740 http://www.ensemblgenomes.org/id/AAC73740 EnsemblBacteria BAA35286 http://www.ensemblgenomes.org/id/BAA35286 EnsemblBacteria BAA35286 http://www.ensemblgenomes.org/id/BAA35286 EnsemblBacteria BAA35286 http://www.ensemblgenomes.org/id/BAA35286 EnsemblBacteria b0639 http://www.ensemblgenomes.org/id/b0639 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000309 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000309 GO_function GO:0004515 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004515 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0034355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034355 GO_process GO:0034628 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034628 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 GeneID 945248 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945248 HAMAP MF_00244 http://hamap.expasy.org/unirule/MF_00244 HOGENOM HOG000262781 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000262781&db=HOGENOM6 InParanoid P0A752 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A752 IntAct P0A752 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A752* IntEnz 2.7.7.18 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.18 InterPro IPR004821 http://www.ebi.ac.uk/interpro/entry/IPR004821 InterPro IPR005248 http://www.ebi.ac.uk/interpro/entry/IPR005248 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0634 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0634 KEGG_Gene eco:b0639 http://www.genome.jp/dbget-bin/www_bget?eco:b0639 KEGG_Orthology KO:K00969 http://www.genome.jp/dbget-bin/www_bget?KO:K00969 KEGG_Pathway ko00760 http://www.genome.jp/kegg-bin/show_pathway?ko00760 KEGG_Reaction rn:R00137 http://www.genome.jp/dbget-bin/www_bget?rn:R00137 KEGG_Reaction rn:R03005 http://www.genome.jp/dbget-bin/www_bget?rn:R03005 OMA FLLLGWD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FLLLGWD PANTHER PTHR12039 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12039 PDB 1K4K http://www.ebi.ac.uk/pdbe-srv/view/entry/1K4K PDB 1K4M http://www.ebi.ac.uk/pdbe-srv/view/entry/1K4M PDBsum 1K4K http://www.ebi.ac.uk/pdbsum/1K4K PDBsum 1K4M http://www.ebi.ac.uk/pdbsum/1K4M PSORT swissprot:NADD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NADD_ECOLI PSORT-B swissprot:NADD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NADD_ECOLI PSORT2 swissprot:NADD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NADD_ECOLI Pfam PF01467 http://pfam.xfam.org/family/PF01467 Phobius swissprot:NADD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NADD_ECOLI PhylomeDB P0A752 http://phylomedb.org/?seqid=P0A752 ProteinModelPortal P0A752 http://www.proteinmodelportal.org/query/uniprot/P0A752 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 10894752 http://www.ncbi.nlm.nih.gov/pubmed/10894752 PubMed 11796112 http://www.ncbi.nlm.nih.gov/pubmed/11796112 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415172 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415172 RefSeq WP_000838889 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000838889 SMR P0A752 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A752 STRING 511145.b0639 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0639&targetmode=cogs STRING COG1057 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1057&targetmode=cogs TIGRFAMs TIGR00125 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00125 TIGRFAMs TIGR00482 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00482 UniProtKB NADD_ECOLI http://www.uniprot.org/uniprot/NADD_ECOLI UniProtKB-AC P0A752 http://www.uniprot.org/uniprot/P0A752 charge swissprot:NADD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NADD_ECOLI eggNOG COG1057 http://eggnogapi.embl.de/nog_data/html/tree/COG1057 eggNOG ENOG4108Z1W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Z1W epestfind swissprot:NADD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NADD_ECOLI garnier swissprot:NADD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NADD_ECOLI helixturnhelix swissprot:NADD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NADD_ECOLI hmoment swissprot:NADD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NADD_ECOLI iep swissprot:NADD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NADD_ECOLI inforesidue swissprot:NADD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NADD_ECOLI octanol swissprot:NADD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NADD_ECOLI pepcoil swissprot:NADD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NADD_ECOLI pepdigest swissprot:NADD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NADD_ECOLI pepinfo swissprot:NADD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NADD_ECOLI pepnet swissprot:NADD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NADD_ECOLI pepstats swissprot:NADD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NADD_ECOLI pepwheel swissprot:NADD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NADD_ECOLI pepwindow swissprot:NADD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NADD_ECOLI sigcleave swissprot:NADD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NADD_ECOLI ## Database ID URL or Descriptions # AltName SYFB_ECOLI Phenylalanyl-tRNA synthetase beta subunit # BioGrid 4262088 189 # CATALYTIC ACTIVITY SYFB_ECOLI ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). # CDD cd02796 tRNA_bind_bactPheRS # COFACTOR SYFB_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250}; Note=Binds 2 magnesium ions per tetramer. {ECO 0000250}; # EcoGene EG10710 pheT # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0009328 phenylalanine-tRNA ligase complex; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0000049 tRNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0004826 phenylalanine-tRNA ligase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006432 phenylalanyl-tRNA aminoacylation; IMP:EcoCyc. # GO_process GO:0008033 tRNA processing; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0006520 cellular amino acid metabolic process # Gene3D 3.30.56.20 -; 1. # Gene3D 3.30.70.380 -; 1. # Gene3D 3.50.40.10 -; 1. # HAMAP MF_00283 Phe_tRNA_synth_beta1 # INTERACTION SYFB_ECOLI Self; NbExp=2; IntAct=EBI-555713, EBI-555713; P32715 mdtO; NbExp=3; IntAct=EBI-555713, EBI-555775; P08312 pheS; NbExp=7; IntAct=EBI-555713, EBI-555676; P0AG90 secD; NbExp=3; IntAct=EBI-555713, EBI-555724; # IntAct P07395 12 # InterPro IPR002547 tRNA-bd_dom # InterPro IPR004532 Phe-tRNA-ligase_IIc_bsu # InterPro IPR005121 PheS_beta_Fdx_antiC-bd # InterPro IPR005146 B3/B4_tRNA-bd # InterPro IPR005147 tRNA_synthase_B5-dom # InterPro IPR009061 DNA-bd_dom_put # InterPro IPR012340 NA-bd_OB-fold # InterPro IPR020825 Phe-tRNA_synthase_B3/B4 # InterPro IPR033714 tRNA_bind_bactPheRS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01007 Amino acid related enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # KEGG_Pathway ko00970 Aminoacyl-tRNA biosynthesis # Organism SYFB_ECOLI Escherichia coli (strain K12) # PATRIC 32118732 VBIEscCol129921_1784 # PDB 3PCO X-ray; 3.02 A; B/D=1-795 # PIR I41284 SYECFB # PROSITE PS50886 TRBD # PROSITE PS51447 FDX_ACB # PROSITE PS51483 B5 # Pfam PF01588 tRNA_bind # Pfam PF03147 FDX-ACB # Pfam PF03483 B3_4 # Pfam PF03484 B5 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SYFB_ECOLI Phenylalanine--tRNA ligase beta subunit # RefSeq NP_416228 NC_000913.3 # RefSeq WP_000672380 NZ_LN832404.1 # SIMILARITY Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. {ECO 0000305}. # SIMILARITY Contains 1 B5 domain. {ECO 0000305}. # SIMILARITY Contains 1 FDX-ACB domain. {ECO 0000305}. # SIMILARITY Contains 1 tRNA-binding domain. {ECO 0000305}. # SMART SM00873 B3_4 # SMART SM00874 B5 # SMART SM00896 FDX-ACB # SUBCELLULAR LOCATION SYFB_ECOLI Cytoplasm. # SUBUNIT SYFB_ECOLI Tetramer of two alpha and two beta subunits. # SUPFAM SSF46955 SSF46955 # SUPFAM SSF50249 SSF50249 # SUPFAM SSF54991 SSF54991 # SUPFAM SSF56037 SSF56037 # TIGRFAMs TIGR00472 pheT_bact # eggNOG COG0072 LUCA # eggNOG COG0073 LUCA # eggNOG ENOG4105C6A Bacteria BLAST swissprot:SYFB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SYFB_ECOLI BioCyc ECOL316407:JW1703-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1703-MONOMER BioCyc EcoCyc:PHET-MONOMER http://biocyc.org/getid?id=EcoCyc:PHET-MONOMER BioCyc MetaCyc:PHET-MONOMER http://biocyc.org/getid?id=MetaCyc:PHET-MONOMER COG COG0072 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0072 DIP DIP-6879N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-6879N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.1.1.20 http://www.genome.jp/dbget-bin/www_bget?EC:6.1.1.20 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K02844 http://www.ebi.ac.uk/ena/data/view/K02844 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00291 http://www.ebi.ac.uk/ena/data/view/V00291 ENZYME 6.1.1.20 http://enzyme.expasy.org/EC/6.1.1.20 EchoBASE EB0704 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0704 EcoGene EG10710 http://www.ecogene.org/geneInfo.php?eg_id=EG10710 EnsemblBacteria AAC74783 http://www.ensemblgenomes.org/id/AAC74783 EnsemblBacteria AAC74783 http://www.ensemblgenomes.org/id/AAC74783 EnsemblBacteria BAA15481 http://www.ensemblgenomes.org/id/BAA15481 EnsemblBacteria BAA15481 http://www.ensemblgenomes.org/id/BAA15481 EnsemblBacteria BAA15481 http://www.ensemblgenomes.org/id/BAA15481 EnsemblBacteria b1713 http://www.ensemblgenomes.org/id/b1713 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0009328 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009328 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0000049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000049 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0004826 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004826 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006432 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006432 GO_process GO:0008033 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008033 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 Gene3D 3.30.56.20 http://www.cathdb.info/version/latest/superfamily/3.30.56.20 Gene3D 3.30.70.380 http://www.cathdb.info/version/latest/superfamily/3.30.70.380 Gene3D 3.50.40.10 http://www.cathdb.info/version/latest/superfamily/3.50.40.10 GeneID 945382 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945382 HAMAP MF_00283 http://hamap.expasy.org/unirule/MF_00283 HOGENOM HOG000292085 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000292085&db=HOGENOM6 InParanoid P07395 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P07395 IntAct P07395 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P07395* IntEnz 6.1.1.20 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.1.1.20 InterPro IPR002547 http://www.ebi.ac.uk/interpro/entry/IPR002547 InterPro IPR004532 http://www.ebi.ac.uk/interpro/entry/IPR004532 InterPro IPR005121 http://www.ebi.ac.uk/interpro/entry/IPR005121 InterPro IPR005146 http://www.ebi.ac.uk/interpro/entry/IPR005146 InterPro IPR005147 http://www.ebi.ac.uk/interpro/entry/IPR005147 InterPro IPR009061 http://www.ebi.ac.uk/interpro/entry/IPR009061 InterPro IPR012340 http://www.ebi.ac.uk/interpro/entry/IPR012340 InterPro IPR020825 http://www.ebi.ac.uk/interpro/entry/IPR020825 InterPro IPR033714 http://www.ebi.ac.uk/interpro/entry/IPR033714 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW1703 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1703 KEGG_Gene eco:b1713 http://www.genome.jp/dbget-bin/www_bget?eco:b1713 KEGG_Orthology KO:K01890 http://www.genome.jp/dbget-bin/www_bget?KO:K01890 KEGG_Pathway ko00970 http://www.genome.jp/kegg-bin/show_pathway?ko00970 KEGG_Reaction rn:R03660 http://www.genome.jp/dbget-bin/www_bget?rn:R03660 MINT MINT-1231494 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1231494 OMA MKFSEQW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MKFSEQW PDB 3PCO http://www.ebi.ac.uk/pdbe-srv/view/entry/3PCO PDBsum 3PCO http://www.ebi.ac.uk/pdbsum/3PCO PROSITE PS50886 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50886 PROSITE PS51447 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51447 PROSITE PS51483 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51483 PSORT swissprot:SYFB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SYFB_ECOLI PSORT-B swissprot:SYFB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SYFB_ECOLI PSORT2 swissprot:SYFB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SYFB_ECOLI Pfam PF01588 http://pfam.xfam.org/family/PF01588 Pfam PF03147 http://pfam.xfam.org/family/PF03147 Pfam PF03483 http://pfam.xfam.org/family/PF03483 Pfam PF03484 http://pfam.xfam.org/family/PF03484 Phobius swissprot:SYFB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SYFB_ECOLI PhylomeDB P07395 http://phylomedb.org/?seqid=P07395 ProteinModelPortal P07395 http://www.proteinmodelportal.org/query/uniprot/P07395 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2991205 http://www.ncbi.nlm.nih.gov/pubmed/2991205 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_416228 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416228 RefSeq WP_000672380 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000672380 SMART SM00873 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00873 SMART SM00874 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00874 SMART SM00896 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00896 SMR P07395 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P07395 STRING 511145.b1713 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1713&targetmode=cogs STRING COG0072 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0072&targetmode=cogs SUPFAM SSF46955 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46955 SUPFAM SSF50249 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50249 SUPFAM SSF54991 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54991 SUPFAM SSF56037 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56037 SWISS-2DPAGE P07395 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P07395 TIGRFAMs TIGR00472 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00472 UniProtKB SYFB_ECOLI http://www.uniprot.org/uniprot/SYFB_ECOLI UniProtKB-AC P07395 http://www.uniprot.org/uniprot/P07395 charge swissprot:SYFB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SYFB_ECOLI eggNOG COG0072 http://eggnogapi.embl.de/nog_data/html/tree/COG0072 eggNOG COG0073 http://eggnogapi.embl.de/nog_data/html/tree/COG0073 eggNOG ENOG4105C6A http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C6A epestfind swissprot:SYFB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SYFB_ECOLI garnier swissprot:SYFB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SYFB_ECOLI helixturnhelix swissprot:SYFB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SYFB_ECOLI hmoment swissprot:SYFB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SYFB_ECOLI iep swissprot:SYFB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SYFB_ECOLI inforesidue swissprot:SYFB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SYFB_ECOLI octanol swissprot:SYFB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SYFB_ECOLI pepcoil swissprot:SYFB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SYFB_ECOLI pepdigest swissprot:SYFB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SYFB_ECOLI pepinfo swissprot:SYFB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SYFB_ECOLI pepnet swissprot:SYFB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SYFB_ECOLI pepstats swissprot:SYFB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SYFB_ECOLI pepwheel swissprot:SYFB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SYFB_ECOLI pepwindow swissprot:SYFB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SYFB_ECOLI sigcleave swissprot:SYFB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SYFB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260367 21 # EcoGene EG11389 fliT # FUNCTION FLIT_ECOLI Dual-function protein that regulates the transcription of class 2 flagellar operons and that also acts as an export chaperone for the filament-capping protein FliD. As a transcriptional regulator, acts as an anti-FlhDC factor; it directly binds FlhC, thus inhibiting the binding of the FlhC/FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus. {ECO 0000255|HAMAP- Rule MF_01180}. # GO_component GO:0005829 cytosol; IEA:UniProtKB-SubCell. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006457 protein folding; IEA:UniProtKB-HAMAP. # GO_process GO:0044781 bacterial-type flagellum organization; IEA:UniProtKB-KW. # GO_process GO:0071973 bacterial-type flagellum-dependent cell motility; IMP:EcoCyc. # GO_process GO:1902209 negative regulation of bacterial-type flagellum assembly; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005829 cytosol # GOslim_process GO:0006457 protein folding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0048870 cell motility # HAMAP MF_01180 FliT # INTERACTION FLIT_ECOLI P24216 fliD; NbExp=4; IntAct=EBI-1114780, EBI-1126352; # IntAct P0ABY2 21 # InterPro IPR008622 FliT # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Pathway ko02040 Flagellar assembly # Organism FLIT_ECOLI Escherichia coli (strain K12) # PATRIC 32119187 VBIEscCol129921_2008 # PIR C64956 C64956 # Pfam PF05400 FliT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Flagellar protein FliT {ECO:0000255|HAMAP-Rule MF_01180} # RefSeq NP_416436 NC_000913.3 # RefSeq WP_001015033 NZ_LN832404.1 # SIMILARITY Belongs to the FliT family. {ECO:0000255|HAMAP- Rule MF_01180}. # SUBCELLULAR LOCATION FLIT_ECOLI Cytoplasm, cytosol {ECO 0000305}. # SUBUNIT Homodimer. Interacts with FliD and FlhC. {ECO:0000255|HAMAP-Rule MF_01180}. # eggNOG ENOG4105YXP Bacteria # eggNOG ENOG41124U3 LUCA BLAST swissprot:FLIT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLIT_ECOLI BioCyc ECOL316407:JW1911-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1911-MONOMER BioCyc EcoCyc:EG11389-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11389-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1099/00221287-138-6-1051 http://dx.doi.org/10.1099/00221287-138-6-1051 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M85240 http://www.ebi.ac.uk/ena/data/view/M85240 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1362 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1362 EcoGene EG11389 http://www.ecogene.org/geneInfo.php?eg_id=EG11389 EnsemblBacteria AAC74993 http://www.ensemblgenomes.org/id/AAC74993 EnsemblBacteria AAC74993 http://www.ensemblgenomes.org/id/AAC74993 EnsemblBacteria BAA15754 http://www.ensemblgenomes.org/id/BAA15754 EnsemblBacteria BAA15754 http://www.ensemblgenomes.org/id/BAA15754 EnsemblBacteria BAA15754 http://www.ensemblgenomes.org/id/BAA15754 EnsemblBacteria b1926 http://www.ensemblgenomes.org/id/b1926 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GO_process GO:0044781 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044781 GO_process GO:0071973 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071973 GO_process GO:1902209 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902209 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 GeneID 946433 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946433 HAMAP MF_01180 http://hamap.expasy.org/unirule/MF_01180 HOGENOM HOG000266968 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000266968&db=HOGENOM6 IntAct P0ABY2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABY2* InterPro IPR008622 http://www.ebi.ac.uk/interpro/entry/IPR008622 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW1911 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1911 KEGG_Gene eco:b1926 http://www.genome.jp/dbget-bin/www_bget?eco:b1926 KEGG_Orthology KO:K02423 http://www.genome.jp/dbget-bin/www_bget?KO:K02423 KEGG_Pathway ko02040 http://www.genome.jp/kegg-bin/show_pathway?ko02040 OMA DMEITYL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DMEITYL PSORT swissprot:FLIT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLIT_ECOLI PSORT-B swissprot:FLIT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLIT_ECOLI PSORT2 swissprot:FLIT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLIT_ECOLI Pfam PF05400 http://pfam.xfam.org/family/PF05400 Phobius swissprot:FLIT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLIT_ECOLI ProteinModelPortal P0ABY2 http://www.proteinmodelportal.org/query/uniprot/P0ABY2 PubMed 1527488 http://www.ncbi.nlm.nih.gov/pubmed/1527488 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416436 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416436 RefSeq WP_001015033 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001015033 SMR P0ABY2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABY2 STRING 511145.b1926 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1926&targetmode=cogs UniProtKB FLIT_ECOLI http://www.uniprot.org/uniprot/FLIT_ECOLI UniProtKB-AC P0ABY2 http://www.uniprot.org/uniprot/P0ABY2 charge swissprot:FLIT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLIT_ECOLI eggNOG ENOG4105YXP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105YXP eggNOG ENOG41124U3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41124U3 epestfind swissprot:FLIT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLIT_ECOLI garnier swissprot:FLIT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLIT_ECOLI helixturnhelix swissprot:FLIT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLIT_ECOLI hmoment swissprot:FLIT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLIT_ECOLI iep swissprot:FLIT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLIT_ECOLI inforesidue swissprot:FLIT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLIT_ECOLI octanol swissprot:FLIT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLIT_ECOLI pepcoil swissprot:FLIT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLIT_ECOLI pepdigest swissprot:FLIT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLIT_ECOLI pepinfo swissprot:FLIT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLIT_ECOLI pepnet swissprot:FLIT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLIT_ECOLI pepstats swissprot:FLIT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLIT_ECOLI pepwheel swissprot:FLIT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLIT_ECOLI pepwindow swissprot:FLIT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLIT_ECOLI sigcleave swissprot:FLIT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLIT_ECOLI ## Database ID URL or Descriptions # BioGrid 4260400 8 # CDD cd06174 MFS # EcoGene EG20205 shiA # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015293 symporter activity; IEA:UniProtKB-KW. # GO_function GO:0015530 shikimate transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0015733 shikimate transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR004736 Cit_H_symport # InterPro IPR005828 MFS_sugar_transport-like # InterPro IPR005829 Sugar_transporter_CS # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # KEGG_Brite ko02000 Transporters # Organism SHIA_ECOLI Escherichia coli (strain K12) # PATRIC 32119293 VBIEscCol129921_2059 # PIR G64962 G64962 # PROSITE PS00217 SUGAR_TRANSPORT_2 # PROSITE PS50850 MFS # Pfam PF00083 Sugar_tr # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SHIA_ECOLI Shikimate transporter # RefSeq NP_416488 NC_000913.3 # RefSeq WP_000378575 NZ_LN832404.1 # SIMILARITY Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. {ECO 0000305}. # SUBCELLULAR LOCATION SHIA_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.6 the major facilitator superfamily (mfs) # TIGRFAMs TIGR00883 2A0106 # eggNOG ENOG4105CSH Bacteria # eggNOG ENOG410XP7I LUCA BLAST swissprot:SHIA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SHIA_ECOLI BioCyc ECOL316407:JW1962-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1962-MONOMER BioCyc EcoCyc:SHIA-MONOMER http://biocyc.org/getid?id=EcoCyc:SHIA-MONOMER BioCyc MetaCyc:SHIA-MONOMER http://biocyc.org/getid?id=MetaCyc:SHIA-MONOMER COG COG0477 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0477 DOI 10.1016/S0378-1119(98)00043-2 http://dx.doi.org/10.1016/S0378-1119(98)00043-2 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U88529 http://www.ebi.ac.uk/ena/data/view/U88529 EchoBASE EB4148 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4148 EcoGene EG20205 http://www.ecogene.org/geneInfo.php?eg_id=EG20205 EnsemblBacteria AAC75045 http://www.ensemblgenomes.org/id/AAC75045 EnsemblBacteria AAC75045 http://www.ensemblgenomes.org/id/AAC75045 EnsemblBacteria BAA15801 http://www.ensemblgenomes.org/id/BAA15801 EnsemblBacteria BAA15801 http://www.ensemblgenomes.org/id/BAA15801 EnsemblBacteria BAA15801 http://www.ensemblgenomes.org/id/BAA15801 EnsemblBacteria b1981 http://www.ensemblgenomes.org/id/b1981 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015293 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293 GO_function GO:0015530 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015530 GO_process GO:0015733 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015733 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 946495 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946495 HOGENOM HOG000141611 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000141611&db=HOGENOM6 InParanoid P76350 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76350 InterPro IPR004736 http://www.ebi.ac.uk/interpro/entry/IPR004736 InterPro IPR005828 http://www.ebi.ac.uk/interpro/entry/IPR005828 InterPro IPR005829 http://www.ebi.ac.uk/interpro/entry/IPR005829 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1962 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1962 KEGG_Gene eco:b1981 http://www.genome.jp/dbget-bin/www_bget?eco:b1981 KEGG_Orthology KO:K08172 http://www.genome.jp/dbget-bin/www_bget?KO:K08172 OMA MMTVWMM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MMTVWMM PROSITE PS00217 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00217 PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:SHIA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SHIA_ECOLI PSORT-B swissprot:SHIA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SHIA_ECOLI PSORT2 swissprot:SHIA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SHIA_ECOLI Pfam PF00083 http://pfam.xfam.org/family/PF00083 Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:SHIA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SHIA_ECOLI PhylomeDB P76350 http://phylomedb.org/?seqid=P76350 ProteinModelPortal P76350 http://www.proteinmodelportal.org/query/uniprot/P76350 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9524262 http://www.ncbi.nlm.nih.gov/pubmed/9524262 RefSeq NP_416488 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416488 RefSeq WP_000378575 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000378575 STRING 511145.b1981 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1981&targetmode=cogs STRING COG0477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0477&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.6 http://www.tcdb.org/search/result.php?tc=2.A.1.6 TIGRFAMs TIGR00883 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00883 UniProtKB SHIA_ECOLI http://www.uniprot.org/uniprot/SHIA_ECOLI UniProtKB-AC P76350 http://www.uniprot.org/uniprot/P76350 charge swissprot:SHIA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SHIA_ECOLI eggNOG ENOG4105CSH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CSH eggNOG ENOG410XP7I http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XP7I epestfind swissprot:SHIA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SHIA_ECOLI garnier swissprot:SHIA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SHIA_ECOLI helixturnhelix swissprot:SHIA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SHIA_ECOLI hmoment swissprot:SHIA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SHIA_ECOLI iep swissprot:SHIA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SHIA_ECOLI inforesidue swissprot:SHIA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SHIA_ECOLI octanol swissprot:SHIA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SHIA_ECOLI pepcoil swissprot:SHIA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SHIA_ECOLI pepdigest swissprot:SHIA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SHIA_ECOLI pepinfo swissprot:SHIA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SHIA_ECOLI pepnet swissprot:SHIA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SHIA_ECOLI pepstats swissprot:SHIA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SHIA_ECOLI pepwheel swissprot:SHIA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SHIA_ECOLI pepwindow swissprot:SHIA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SHIA_ECOLI sigcleave swissprot:SHIA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SHIA_ECOLI ## Database ID URL or Descriptions # AltName UXAA_ECOLI D-altronate hydro-lyase # BIOPHYSICOCHEMICAL PROPERTIES pH dependence: Optimum pH is about 7.5. The activity at pH 6.5 and 8.6 is only about 20% of the maximal achievable activity at optimum pH. {ECO 0000269|PubMed:3038546}; # BioGrid 4262407 11 # CATALYTIC ACTIVITY D-altronate = 2-dehydro-3-deoxy-D-gluconate + H(2)O. {ECO:0000269|PubMed 3038546}. # COFACTOR UXAA_ECOLI Name=Fe(2+); Xref=ChEBI CHEBI 29033; Evidence={ECO 0000269|PubMed 3038546}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 3038546}; Note=Mn(2+) can substitute for iron, but in higher concentrations. Cannot use Fe(3+), Ni(2+) or Mg(2+). {ECO 0000269|PubMed 3038546}; # ENZYME REGULATION Is inhibited by high concentrations of Fe(2+) (> 2 mM), and by EDTA or other iron chelators in vitro. {ECO:0000269|PubMed 3038546}. # EcoGene EG12734 uxaA # FUNCTION UXAA_ECOLI Catalyzes the dehydration of D-altronate. {ECO 0000269|PubMed 3038546}. # GO_function GO:0008198 ferrous iron binding; IDA:EcoCyc. # GO_function GO:0008789 altronate dehydratase activity; IEA:UniProtKB-EC. # GO_process GO:0019698 D-galacturonate catabolic process; IMP:EcoCyc. # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # INDUCTION Repressed by LeuO and H-NS. Part of the uxaCA operon. {ECO:0000269|PubMed 19429622}. # IntAct P42604 6 # InterPro IPR007392 Gal/Altron_deHydtase_C # InterPro IPR013974 SAF # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00040 Pentose and glucuronate interconversions # Organism UXAA_ECOLI Escherichia coli (strain K12) # PATHWAY UXAA_ECOLI Carbohydrate metabolism; pentose and glucuronate interconversion. # PATRIC 32121600 VBIEscCol129921_3186 # PIR H65097 H65097 # Pfam PF04295 GD_AH_C # Pfam PF08666 SAF # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UXAA_ECOLI Altronate dehydratase # RefSeq NP_417562 NC_000913.3 # RefSeq WP_001199390 NZ_LN832404.1 # SIMILARITY Belongs to the UxaA family. {ECO 0000305}. # SMART SM00858 SAF # eggNOG COG2721 LUCA # eggNOG ENOG4105CTX Bacteria BLAST swissprot:UXAA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UXAA_ECOLI BioCyc ECOL316407:JW3062-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3062-MONOMER BioCyc EcoCyc:ALTRODEHYDRAT-MONOMER http://biocyc.org/getid?id=EcoCyc:ALTRODEHYDRAT-MONOMER BioCyc MetaCyc:ALTRODEHYDRAT-MONOMER http://biocyc.org/getid?id=MetaCyc:ALTRODEHYDRAT-MONOMER COG COG2721 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2721 DIP DIP-11105N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11105N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1432-1033.1987.tb13559.x http://dx.doi.org/10.1111/j.1432-1033.1987.tb13559.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00108-09 http://dx.doi.org/10.1128/JB.00108-09 EC_number EC:4.2.1.7 http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.7 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D13328 http://www.ebi.ac.uk/ena/data/view/D13328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 4.2.1.7 http://enzyme.expasy.org/EC/4.2.1.7 EchoBASE EB2592 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2592 EcoGene EG12734 http://www.ecogene.org/geneInfo.php?eg_id=EG12734 EnsemblBacteria AAC76126 http://www.ensemblgenomes.org/id/AAC76126 EnsemblBacteria AAC76126 http://www.ensemblgenomes.org/id/AAC76126 EnsemblBacteria BAE77141 http://www.ensemblgenomes.org/id/BAE77141 EnsemblBacteria BAE77141 http://www.ensemblgenomes.org/id/BAE77141 EnsemblBacteria BAE77141 http://www.ensemblgenomes.org/id/BAE77141 EnsemblBacteria b3091 http://www.ensemblgenomes.org/id/b3091 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008198 GO_function GO:0008789 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008789 GO_process GO:0019698 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019698 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 947603 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947603 HOGENOM HOG000219064 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219064&db=HOGENOM6 InParanoid P42604 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P42604 IntAct P42604 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P42604* IntEnz 4.2.1.7 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.7 InterPro IPR007392 http://www.ebi.ac.uk/interpro/entry/IPR007392 InterPro IPR013974 http://www.ebi.ac.uk/interpro/entry/IPR013974 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3062 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3062 KEGG_Gene eco:b3091 http://www.genome.jp/dbget-bin/www_bget?eco:b3091 KEGG_Orthology KO:K01685 http://www.genome.jp/dbget-bin/www_bget?KO:K01685 KEGG_Pathway ko00040 http://www.genome.jp/kegg-bin/show_pathway?ko00040 KEGG_Reaction rn:R01540 http://www.genome.jp/dbget-bin/www_bget?rn:R01540 OMA GDDHENT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GDDHENT PSORT swissprot:UXAA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UXAA_ECOLI PSORT-B swissprot:UXAA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UXAA_ECOLI PSORT2 swissprot:UXAA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UXAA_ECOLI Pfam PF04295 http://pfam.xfam.org/family/PF04295 Pfam PF08666 http://pfam.xfam.org/family/PF08666 Phobius swissprot:UXAA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UXAA_ECOLI PhylomeDB P42604 http://phylomedb.org/?seqid=P42604 ProteinModelPortal P42604 http://www.proteinmodelportal.org/query/uniprot/P42604 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19429622 http://www.ncbi.nlm.nih.gov/pubmed/19429622 PubMed 3038546 http://www.ncbi.nlm.nih.gov/pubmed/3038546 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417562 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417562 RefSeq WP_001199390 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001199390 SMART SM00858 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00858 SMR P42604 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P42604 STRING 511145.b3091 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3091&targetmode=cogs STRING COG2721 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2721&targetmode=cogs UniProtKB UXAA_ECOLI http://www.uniprot.org/uniprot/UXAA_ECOLI UniProtKB-AC P42604 http://www.uniprot.org/uniprot/P42604 charge swissprot:UXAA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UXAA_ECOLI eggNOG COG2721 http://eggnogapi.embl.de/nog_data/html/tree/COG2721 eggNOG ENOG4105CTX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CTX epestfind swissprot:UXAA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UXAA_ECOLI garnier swissprot:UXAA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UXAA_ECOLI helixturnhelix swissprot:UXAA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UXAA_ECOLI hmoment swissprot:UXAA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UXAA_ECOLI iep swissprot:UXAA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UXAA_ECOLI inforesidue swissprot:UXAA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UXAA_ECOLI octanol swissprot:UXAA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UXAA_ECOLI pepcoil swissprot:UXAA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UXAA_ECOLI pepdigest swissprot:UXAA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UXAA_ECOLI pepinfo swissprot:UXAA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UXAA_ECOLI pepnet swissprot:UXAA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UXAA_ECOLI pepstats swissprot:UXAA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UXAA_ECOLI pepwheel swissprot:UXAA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UXAA_ECOLI pepwindow swissprot:UXAA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UXAA_ECOLI sigcleave swissprot:UXAA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UXAA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260232 14 # COFACTOR RSPB_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000250}; Note=Binds 2 Zn(2+) ions per subunit. {ECO 0000250}; # EcoGene EG12452 rspB # FUNCTION RSPB_ECOLI Not known; probable catabolic enzyme. # GO_function GO:0008270 zinc ion binding; IEA:InterPro. # GO_function GO:0016491 oxidoreductase activity; IEA:UniProtKB-KW. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.720 -; 1. # Gene3D 3.90.180.10 -; 1. # INDUCTION Repressed by RspR. {ECO:0000269|PubMed 22972332}. # InterPro IPR002085 ADH_SF_Zn-type # InterPro IPR002328 ADH_Zn_CS # InterPro IPR011032 GroES-like # InterPro IPR013149 ADH_C # InterPro IPR013154 ADH_N # InterPro IPR016040 NAD(P)-bd_dom # KEGG_Brite ko01000 Enzymes # Organism RSPB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11695 PTHR11695 # PATRIC 32118462 VBIEscCol129921_1651 # PIR I81185 I81185 # PROSITE PS00059 ADH_ZINC # Pfam PF00107 ADH_zinc_N # Pfam PF08240 ADH_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RSPB_ECOLI Starvation-sensing protein RspB # RefSeq NP_416097 NC_000913.3 # RefSeq WP_000836066 NZ_LN832404.1 # SIMILARITY Belongs to the zinc-containing alcohol dehydrogenase family. {ECO 0000305}. # SUPFAM SSF50129 SSF50129 # SUPFAM SSF51735 SSF51735 # eggNOG COG1063 LUCA # eggNOG ENOG4105CPQ Bacteria BLAST swissprot:RSPB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RSPB_ECOLI BioCyc ECOL316407:JW1572-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1572-MONOMER BioCyc EcoCyc:G6838-MONOMER http://biocyc.org/getid?id=EcoCyc:G6838-MONOMER COG COG1063 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1063 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1126/science.7545940 http://dx.doi.org/10.1126/science.7545940 DOI 10.1271/bbb.120273 http://dx.doi.org/10.1271/bbb.120273 EC_number EC:1.1.1.- http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L31628 http://www.ebi.ac.uk/ena/data/view/L31628 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.1.1.- http://enzyme.expasy.org/EC/1.1.1.- EchoBASE EB2346 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2346 EcoGene EG12452 http://www.ecogene.org/geneInfo.php?eg_id=EG12452 EnsemblBacteria AAC74652 http://www.ensemblgenomes.org/id/AAC74652 EnsemblBacteria AAC74652 http://www.ensemblgenomes.org/id/AAC74652 EnsemblBacteria BAA15284 http://www.ensemblgenomes.org/id/BAA15284 EnsemblBacteria BAA15284 http://www.ensemblgenomes.org/id/BAA15284 EnsemblBacteria BAA15284 http://www.ensemblgenomes.org/id/BAA15284 EnsemblBacteria b1580 http://www.ensemblgenomes.org/id/b1580 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 Gene3D 3.90.180.10 http://www.cathdb.info/version/latest/superfamily/3.90.180.10 GeneID 946127 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946127 HOGENOM HOG000294690 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000294690&db=HOGENOM6 InParanoid P38105 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P38105 IntAct P38105 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P38105* IntEnz 1.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1 InterPro IPR002085 http://www.ebi.ac.uk/interpro/entry/IPR002085 InterPro IPR002328 http://www.ebi.ac.uk/interpro/entry/IPR002328 InterPro IPR011032 http://www.ebi.ac.uk/interpro/entry/IPR011032 InterPro IPR013149 http://www.ebi.ac.uk/interpro/entry/IPR013149 InterPro IPR013154 http://www.ebi.ac.uk/interpro/entry/IPR013154 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1572 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1572 KEGG_Gene eco:b1580 http://www.genome.jp/dbget-bin/www_bget?eco:b1580 KEGG_Orthology KO:K08322 http://www.genome.jp/dbget-bin/www_bget?KO:K08322 OMA FAVMVEP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FAVMVEP PANTHER PTHR11695 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11695 PROSITE PS00059 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00059 PSORT swissprot:RSPB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RSPB_ECOLI PSORT-B swissprot:RSPB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RSPB_ECOLI PSORT2 swissprot:RSPB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RSPB_ECOLI Pfam PF00107 http://pfam.xfam.org/family/PF00107 Pfam PF08240 http://pfam.xfam.org/family/PF08240 Phobius swissprot:RSPB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RSPB_ECOLI PhylomeDB P38105 http://phylomedb.org/?seqid=P38105 ProteinModelPortal P38105 http://www.proteinmodelportal.org/query/uniprot/P38105 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22972332 http://www.ncbi.nlm.nih.gov/pubmed/22972332 PubMed 7545940 http://www.ncbi.nlm.nih.gov/pubmed/7545940 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416097 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416097 RefSeq WP_000836066 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000836066 SMR P38105 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P38105 STRING 511145.b1580 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1580&targetmode=cogs STRING COG1063 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1063&targetmode=cogs SUPFAM SSF50129 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50129 SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB RSPB_ECOLI http://www.uniprot.org/uniprot/RSPB_ECOLI UniProtKB-AC P38105 http://www.uniprot.org/uniprot/P38105 charge swissprot:RSPB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RSPB_ECOLI eggNOG COG1063 http://eggnogapi.embl.de/nog_data/html/tree/COG1063 eggNOG ENOG4105CPQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CPQ epestfind swissprot:RSPB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RSPB_ECOLI garnier swissprot:RSPB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RSPB_ECOLI helixturnhelix swissprot:RSPB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RSPB_ECOLI hmoment swissprot:RSPB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RSPB_ECOLI iep swissprot:RSPB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RSPB_ECOLI inforesidue swissprot:RSPB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RSPB_ECOLI octanol swissprot:RSPB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RSPB_ECOLI pepcoil swissprot:RSPB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RSPB_ECOLI pepdigest swissprot:RSPB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RSPB_ECOLI pepinfo swissprot:RSPB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RSPB_ECOLI pepnet swissprot:RSPB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RSPB_ECOLI pepstats swissprot:RSPB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RSPB_ECOLI pepwheel swissprot:RSPB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RSPB_ECOLI pepwindow swissprot:RSPB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RSPB_ECOLI sigcleave swissprot:RSPB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RSPB_ECOLI ## Database ID URL or Descriptions # BRENDA 1.2.1.39 2026 # BioGrid 4261813 11 # CATALYTIC ACTIVITY FEAB_ECOLI Phenylacetaldehyde + NAD(+) + H(2)O = phenylacetate + NADH. # EcoGene EG13179 feaB # FUNCTION FEAB_ECOLI Acts almost equally well on phenylacetaldehyde, 4- hydroxyphenylacetaldehyde and 3,4-dihydroxyphenylacetaldehyde. # GO_function GO:0008957 phenylacetaldehyde dehydrogenase activity; IDA:EcoliWiki. # GO_function GO:0016491 oxidoreductase activity; IDA:EcoliWiki. # GO_function GO:0047106 4-hydroxyphenylacetaldehyde dehydrogenase activity; IDA:EcoliWiki. # GO_process GO:0006559 L-phenylalanine catabolic process; IEA:UniProtKB-UniPathway. # GO_process GO:0009435 NAD biosynthetic process; IDA:EcoliWiki. # GO_process GO:0046196 4-nitrophenol catabolic process; IDA:EcoliWiki. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.309.10 -; 1. # Gene3D 3.40.605.10 -; 1. # InterPro IPR015590 Aldehyde_DH_dom # InterPro IPR016160 Ald_DH_CS_CYS # InterPro IPR016161 Ald_DH/histidinol_DH # InterPro IPR016162 Ald_DH_N # InterPro IPR016163 Ald_DH_C # InterPro IPR029510 Ald_DH_CS_GLU # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00360 Phenylalanine metabolism # KEGG_Pathway ko00643 Styrene degradation # MISCELLANEOUS FEAB_ECOLI Can also use NADP, but prefers NAD. # Organism FEAB_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid degradation; L-phenylalanine degradation; phenylacetate from L-phenylalanine step 3/3. # PATRIC 32118056 VBIEscCol129921_1448 # PIR D64889 D64889 # PROSITE PS00070 ALDEHYDE_DEHYDR_CYS # PROSITE PS00687 ALDEHYDE_DEHYDR_GLU # Pfam PF00171 Aldedh # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FEAB_ECOLI Phenylacetaldehyde dehydrogenase # RefSeq NP_415903 NC_000913.3 # RefSeq WP_000138615 NZ_LN832404.1 # SIMILARITY Belongs to the aldehyde dehydrogenase family. {ECO 0000305}. # SUBUNIT FEAB_ECOLI Homodimer. # SUPFAM SSF53720 SSF53720 # UniPathway UPA00139 UER00724 # eggNOG COG1012 LUCA # eggNOG ENOG4105C26 Bacteria BLAST swissprot:FEAB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FEAB_ECOLI BioCyc ECOL316407:JW1380-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1380-MONOMER BioCyc EcoCyc:PHENDEHYD-MONOMER http://biocyc.org/getid?id=EcoCyc:PHENDEHYD-MONOMER BioCyc MetaCyc:PHENDEHYD-MONOMER http://biocyc.org/getid?id=MetaCyc:PHENDEHYD-MONOMER COG COG1012 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1012 DIP DIP-9581N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9581N DOI 10.1016/S0014-5793(97)00228-7 http://dx.doi.org/10.1016/S0014-5793(97)00228-7 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1099/00221287-143-2-513 http://dx.doi.org/10.1099/00221287-143-2-513 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.2.1.39 http://www.genome.jp/dbget-bin/www_bget?EC:1.2.1.39 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D23670 http://www.ebi.ac.uk/ena/data/view/D23670 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X97453 http://www.ebi.ac.uk/ena/data/view/X97453 EMBL X99402 http://www.ebi.ac.uk/ena/data/view/X99402 ENZYME 1.2.1.39 http://enzyme.expasy.org/EC/1.2.1.39 EchoBASE EB2971 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2971 EcoGene EG13179 http://www.ecogene.org/geneInfo.php?eg_id=EG13179 EnsemblBacteria AAC74467 http://www.ensemblgenomes.org/id/AAC74467 EnsemblBacteria AAC74467 http://www.ensemblgenomes.org/id/AAC74467 EnsemblBacteria BAA14992 http://www.ensemblgenomes.org/id/BAA14992 EnsemblBacteria BAA14992 http://www.ensemblgenomes.org/id/BAA14992 EnsemblBacteria BAA14992 http://www.ensemblgenomes.org/id/BAA14992 EnsemblBacteria b1385 http://www.ensemblgenomes.org/id/b1385 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008957 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008957 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0047106 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047106 GO_process GO:0006559 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006559 GO_process GO:0009435 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009435 GO_process GO:0046196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046196 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.309.10 http://www.cathdb.info/version/latest/superfamily/3.40.309.10 Gene3D 3.40.605.10 http://www.cathdb.info/version/latest/superfamily/3.40.605.10 GeneID 945933 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945933 HOGENOM HOG000271505 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000271505&db=HOGENOM6 InParanoid P80668 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P80668 IntAct P80668 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P80668* IntEnz 1.2.1.39 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.2.1.39 InterPro IPR015590 http://www.ebi.ac.uk/interpro/entry/IPR015590 InterPro IPR016160 http://www.ebi.ac.uk/interpro/entry/IPR016160 InterPro IPR016161 http://www.ebi.ac.uk/interpro/entry/IPR016161 InterPro IPR016162 http://www.ebi.ac.uk/interpro/entry/IPR016162 InterPro IPR016163 http://www.ebi.ac.uk/interpro/entry/IPR016163 InterPro IPR029510 http://www.ebi.ac.uk/interpro/entry/IPR029510 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1380 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1380 KEGG_Gene eco:b1385 http://www.genome.jp/dbget-bin/www_bget?eco:b1385 KEGG_Orthology KO:K00146 http://www.genome.jp/dbget-bin/www_bget?KO:K00146 KEGG_Pathway ko00360 http://www.genome.jp/kegg-bin/show_pathway?ko00360 KEGG_Pathway ko00643 http://www.genome.jp/kegg-bin/show_pathway?ko00643 KEGG_Reaction rn:R02536 http://www.genome.jp/dbget-bin/www_bget?rn:R02536 MINT MINT-1256983 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1256983 OMA INISRAF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=INISRAF PROSITE PS00070 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00070 PROSITE PS00687 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00687 PSORT swissprot:FEAB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FEAB_ECOLI PSORT-B swissprot:FEAB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FEAB_ECOLI PSORT2 swissprot:FEAB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FEAB_ECOLI Pfam PF00171 http://pfam.xfam.org/family/PF00171 Phobius swissprot:FEAB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FEAB_ECOLI PhylomeDB P80668 http://phylomedb.org/?seqid=P80668 ProteinModelPortal P80668 http://www.proteinmodelportal.org/query/uniprot/P80668 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9043126 http://www.ncbi.nlm.nih.gov/pubmed/9043126 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9109378 http://www.ncbi.nlm.nih.gov/pubmed/9109378 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415903 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415903 RefSeq WP_000138615 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000138615 SMR P80668 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P80668 STRING 511145.b1385 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1385&targetmode=cogs STRING COG1012 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1012&targetmode=cogs SUPFAM SSF53720 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53720 UniProtKB FEAB_ECOLI http://www.uniprot.org/uniprot/FEAB_ECOLI UniProtKB-AC P80668 http://www.uniprot.org/uniprot/P80668 charge swissprot:FEAB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FEAB_ECOLI eggNOG COG1012 http://eggnogapi.embl.de/nog_data/html/tree/COG1012 eggNOG ENOG4105C26 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C26 epestfind swissprot:FEAB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FEAB_ECOLI garnier swissprot:FEAB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FEAB_ECOLI helixturnhelix swissprot:FEAB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FEAB_ECOLI hmoment swissprot:FEAB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FEAB_ECOLI iep swissprot:FEAB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FEAB_ECOLI inforesidue swissprot:FEAB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FEAB_ECOLI octanol swissprot:FEAB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FEAB_ECOLI pepcoil swissprot:FEAB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FEAB_ECOLI pepdigest swissprot:FEAB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FEAB_ECOLI pepinfo swissprot:FEAB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FEAB_ECOLI pepnet swissprot:FEAB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FEAB_ECOLI pepstats swissprot:FEAB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FEAB_ECOLI pepwheel swissprot:FEAB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FEAB_ECOLI pepwindow swissprot:FEAB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FEAB_ECOLI sigcleave swissprot:FEAB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FEAB_ECOLI ## Database ID URL or Descriptions # BioGrid 4262197 12 # DISRUPTION PHENOTYPE Deletion increases the susceptibility to DL- ethionine, DL-norleucine and DL-norvaline. Deletion also results in intracellular accumulation and a reduced rate of export of methionine in the presence of extracellular Met-Met dipeptides. {ECO:0000269|PubMed 26319875}. # ENZYME REGULATION Efflux is inhibited by carbonyl cyanide m- chlorophenylhydrazone (CCCP). {ECO:0000269|PubMed 26319875}. # EcoGene EG12470 yjeH # FUNCTION YJEH_ECOLI Catalyzes the efflux of L-methionine. Can also export L- leucine, L-isoleucine and L-valine. Activity is dependent on electrochemical potential. {ECO 0000269|PubMed 26319875}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; ISM:EcoCyc. # GO_function GO:0000102 L-methionine secondary active transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0015297 antiporter activity; IBA:GO_Central. # GO_process GO:0015820 leucine transport; IMP:EcoCyc. # GO_process GO:0015821 methionine transport; IMP:EcoCyc. # GO_process GO:0071230 cellular response to amino acid stimulus; IEP:EcoCyc. # GO_process GO:1903714 isoleucine transmembrane transport; IMP:EcoCyc. # GO_process GO:1903785 L-valine transmembrane transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # GOslim_process GO:0055085 transmembrane transport # INDUCTION Induced in the presence of intracellular L-methionine, L-leucine or L-isoleucine. {ECO:0000269|PubMed 26319875}. # IntAct P39277 3 # InterPro IPR002293 AA/rel_permease1 # KEGG_Brite ko02000 Transporters # Organism YJEH_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11785 PTHR11785 # PATRIC 32123851 VBIEscCol129921_4273 # PIR S56369 S56369 # PIRSF PIRSF006060 AA_transporter # Pfam PF13520 AA_permease_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName L-methionine/branched-chain amino acid exporter YjeH {ECO 0000305} # RefSeq NP_418565 NC_000913.3 # RefSeq WP_000015837 NZ_LN832404.1 # SIMILARITY Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid efflux (AAE) (TC 2.A.3.13) family. {ECO 0000305}. # SUBCELLULAR LOCATION YJEH_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 26319875}; Multi- pass membrane protein {ECO 0000255}. # TCDB 2.A.3.13 the amino acid-polyamine-organocation (apc) family # eggNOG COG0531 LUCA # eggNOG ENOG4105DVH Bacteria BLAST swissprot:YJEH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJEH_ECOLI BioCyc ECOL316407:JW4101-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4101-MONOMER BioCyc EcoCyc:B4141-MONOMER http://biocyc.org/getid?id=EcoCyc:B4141-MONOMER BioCyc MetaCyc:B4141-MONOMER http://biocyc.org/getid?id=MetaCyc:B4141-MONOMER COG COG0531 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0531 DIP DIP-12573N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12573N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AEM.02242-15 http://dx.doi.org/10.1128/AEM.02242-15 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2363 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2363 EcoGene EG12470 http://www.ecogene.org/geneInfo.php?eg_id=EG12470 EnsemblBacteria AAC77101 http://www.ensemblgenomes.org/id/AAC77101 EnsemblBacteria AAC77101 http://www.ensemblgenomes.org/id/AAC77101 EnsemblBacteria BAE78143 http://www.ensemblgenomes.org/id/BAE78143 EnsemblBacteria BAE78143 http://www.ensemblgenomes.org/id/BAE78143 EnsemblBacteria BAE78143 http://www.ensemblgenomes.org/id/BAE78143 EnsemblBacteria b4141 http://www.ensemblgenomes.org/id/b4141 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0000102 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000102 GO_function GO:0005294 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005294 GO_function GO:0015297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015297 GO_process GO:0015820 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015820 GO_process GO:0015821 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015821 GO_process GO:0071230 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071230 GO_process GO:1903714 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903714 GO_process GO:1903785 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903785 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 948656 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948656 HOGENOM HOG000273866 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000273866&db=HOGENOM6 InParanoid P39277 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39277 IntAct P39277 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39277* InterPro IPR002293 http://www.ebi.ac.uk/interpro/entry/IPR002293 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW4101 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4101 KEGG_Gene eco:b4141 http://www.genome.jp/dbget-bin/www_bget?eco:b4141 KEGG_Orthology KO:K16263 http://www.genome.jp/dbget-bin/www_bget?KO:K16263 OMA TVYWACT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TVYWACT PANTHER PTHR11785 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11785 PSORT swissprot:YJEH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJEH_ECOLI PSORT-B swissprot:YJEH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJEH_ECOLI PSORT2 swissprot:YJEH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJEH_ECOLI Pfam PF13520 http://pfam.xfam.org/family/PF13520 Phobius swissprot:YJEH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJEH_ECOLI PhylomeDB P39277 http://phylomedb.org/?seqid=P39277 ProteinModelPortal P39277 http://www.proteinmodelportal.org/query/uniprot/P39277 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 26319875 http://www.ncbi.nlm.nih.gov/pubmed/26319875 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418565 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418565 RefSeq WP_000015837 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000015837 STRING 511145.b4141 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4141&targetmode=cogs STRING COG0531 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0531&targetmode=cogs TCDB 2.A.3.13 http://www.tcdb.org/search/result.php?tc=2.A.3.13 UniProtKB YJEH_ECOLI http://www.uniprot.org/uniprot/YJEH_ECOLI UniProtKB-AC P39277 http://www.uniprot.org/uniprot/P39277 charge swissprot:YJEH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJEH_ECOLI eggNOG COG0531 http://eggnogapi.embl.de/nog_data/html/tree/COG0531 eggNOG ENOG4105DVH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DVH epestfind swissprot:YJEH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJEH_ECOLI garnier swissprot:YJEH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJEH_ECOLI helixturnhelix swissprot:YJEH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJEH_ECOLI hmoment swissprot:YJEH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJEH_ECOLI iep swissprot:YJEH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJEH_ECOLI inforesidue swissprot:YJEH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJEH_ECOLI octanol swissprot:YJEH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJEH_ECOLI pepcoil swissprot:YJEH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJEH_ECOLI pepdigest swissprot:YJEH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJEH_ECOLI pepinfo swissprot:YJEH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJEH_ECOLI pepnet swissprot:YJEH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJEH_ECOLI pepstats swissprot:YJEH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJEH_ECOLI pepwheel swissprot:YJEH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJEH_ECOLI pepwindow swissprot:YJEH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJEH_ECOLI sigcleave swissprot:YJEH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJEH_ECOLI ## Database ID URL or Descriptions # BioGrid 4259192 11 # EcoGene EG12644 yfeK # Organism YFEK_ECOLI Escherichia coli (strain K12) # PATRIC 32120221 VBIEscCol129921_2513 # PIR B65016 B65016 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFEK_ECOLI Uncharacterized protein YfeK # RefSeq NP_416914 NC_000913.3 # RefSeq WP_000719962 NZ_LN832404.1 # eggNOG ENOG4105M0Y Bacteria # eggNOG ENOG4111UQK LUCA BLAST swissprot:YFEK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFEK_ECOLI BioCyc ECOL316407:JW2412-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2412-MONOMER BioCyc EcoCyc:G7260-MONOMER http://biocyc.org/getid?id=EcoCyc:G7260-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1574-6968.1996.tb08368.x http://dx.doi.org/10.1111/j.1574-6968.1996.tb08368.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U53700 http://www.ebi.ac.uk/ena/data/view/U53700 EchoBASE EB2520 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2520 EcoGene EG12644 http://www.ecogene.org/geneInfo.php?eg_id=EG12644 EnsemblBacteria AAC75472 http://www.ensemblgenomes.org/id/AAC75472 EnsemblBacteria AAC75472 http://www.ensemblgenomes.org/id/AAC75472 EnsemblBacteria BAA16293 http://www.ensemblgenomes.org/id/BAA16293 EnsemblBacteria BAA16293 http://www.ensemblgenomes.org/id/BAA16293 EnsemblBacteria BAA16293 http://www.ensemblgenomes.org/id/BAA16293 EnsemblBacteria b2419 http://www.ensemblgenomes.org/id/b2419 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946876 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946876 HOGENOM HOG000122975 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122975&db=HOGENOM6 InParanoid Q47702 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q47702 IntAct Q47702 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q47702* KEGG_Gene ecj:JW2412 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2412 KEGG_Gene eco:b2419 http://www.genome.jp/dbget-bin/www_bget?eco:b2419 OMA ANVNAHE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ANVNAHE PSORT swissprot:YFEK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFEK_ECOLI PSORT-B swissprot:YFEK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFEK_ECOLI PSORT2 swissprot:YFEK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFEK_ECOLI Phobius swissprot:YFEK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFEK_ECOLI ProteinModelPortal Q47702 http://www.proteinmodelportal.org/query/uniprot/Q47702 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8764513 http://www.ncbi.nlm.nih.gov/pubmed/8764513 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416914 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416914 RefSeq WP_000719962 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000719962 STRING 511145.b2419 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2419&targetmode=cogs UniProtKB YFEK_ECOLI http://www.uniprot.org/uniprot/YFEK_ECOLI UniProtKB-AC Q47702 http://www.uniprot.org/uniprot/Q47702 charge swissprot:YFEK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFEK_ECOLI eggNOG ENOG4105M0Y http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105M0Y eggNOG ENOG4111UQK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111UQK epestfind swissprot:YFEK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFEK_ECOLI garnier swissprot:YFEK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFEK_ECOLI helixturnhelix swissprot:YFEK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFEK_ECOLI hmoment swissprot:YFEK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFEK_ECOLI iep swissprot:YFEK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFEK_ECOLI inforesidue swissprot:YFEK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFEK_ECOLI octanol swissprot:YFEK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFEK_ECOLI pepcoil swissprot:YFEK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFEK_ECOLI pepdigest swissprot:YFEK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFEK_ECOLI pepinfo swissprot:YFEK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFEK_ECOLI pepnet swissprot:YFEK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFEK_ECOLI pepstats swissprot:YFEK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFEK_ECOLI pepwheel swissprot:YFEK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFEK_ECOLI pepwindow swissprot:YFEK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFEK_ECOLI sigcleave swissprot:YFEK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFEK_ECOLI ## Database ID URL or Descriptions # AltName XNI_ECOLI Exonuclease IX # BioGrid 4259222 102 # CAUTION XNI_ECOLI Was initially reported (PubMed 9592142) as a 3'-5' exonuclease due to contamination of samples. This protein possesses no such activity (PubMed 17567612 and PubMed 19000038). {ECO 0000305|PubMed 9592142}. # COFACTOR XNI_ECOLI Name=K(+); Xref=ChEBI CHEBI 29103; Evidence={ECO 0000269|PubMed 23821668}; Note=Binds 1 K(+) per subunit. The potassium ion strongly increases the affinity for DNA. {ECO 0000269|PubMed 23821668}; # COFACTOR XNI_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 23821668}; Note=Binds 2 Mg(2+) per subunit. Only one magnesium ion has a direct interaction with the protein, the other interactions are indirect. {ECO 0000269|PubMed 23821668}; # DISRUPTION PHENOTYPE Can be deleted, however double-disruptions of polA and xni are not viable, suggesting they have a redundant essential function. {ECO:0000269|PubMed 17905985}. # EcoGene EG12372 ygdG # FUNCTION XNI_ECOLI Has flap endonuclease activity (PubMed 23821668), but does not seem to have exonuclease activity (PubMed 17567612 and PubMed 19000038). During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. {ECO 0000269|PubMed 17567612, ECO 0000269|PubMed 19000038, ECO 0000269|PubMed 23821668}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0000287 magnesium ion binding; IDA:UniProtKB. # GO_function GO:0003677 DNA binding; IDA:UniProtKB. # GO_function GO:0017108 5'-flap endonuclease activity; IDA:UniProtKB. # GO_function GO:0030955 potassium ion binding; IDA:UniProtKB. # GO_process GO:0033567 DNA replication, Okazaki fragment processing; IDA:UniProtKB. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004518 nuclease activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # Gene3D 3.40.50.1010 -; 1. # HAMAP MF_01192 Xni # IntAct P38506 3 # InterPro IPR002421 5-3_exonuclease_N # InterPro IPR008918 HhH2 # InterPro IPR020045 5-3_exonuclease_C # InterPro IPR020046 5-3_exonucl_a-hlix_arch_N # InterPro IPR022895 Xni # InterPro IPR029060 PIN_domain-like # Organism XNI_ECOLI Escherichia coli (strain K12) # PATRIC 32121012 VBIEscCol129921_2898 # PDB 3ZD8 X-ray; 2.00 A; A/B=1-251 # PDB 3ZD9 X-ray; 2.00 A; A=1-251 # PDB 3ZDA X-ray; 1.50 A; A=1-251 # PDB 3ZDB X-ray; 1.47 A; A=1-251 # PDB 3ZDC X-ray; 1.53 A; A=1-251 # PDB 3ZDD X-ray; 1.50 A; A=1-251 # PDB 3ZDE X-ray; 2.45 A; A=1-251 # PIR B65062 B65062 # Pfam PF01367 5_3_exonuc # Pfam PF02739 5_3_exonuc_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName XNI_ECOLI Flap endonuclease Xni # RefSeq NP_417278 NC_000913.3 # RefSeq WP_000268232 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40448.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAE76870.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the Xni family. {ECO 0000305}. # SIMILARITY Contains 1 5'-3' exonuclease domain. {ECO 0000305}. # SMART SM00279 HhH2 # SMART SM00475 53EXOc # SUBUNIT Interacts with the DNA-binding proteins SSB and H-NS. {ECO:0000269|PubMed 17567612}. # SUPFAM SSF47807 SSF47807 # SUPFAM SSF88723 SSF88723 # eggNOG COG0258 LUCA # eggNOG ENOG4105CIQ Bacteria BLAST swissprot:XNI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:XNI_ECOLI BioCyc ECOL316407:JW5446-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5446-MONOMER BioCyc EcoCyc:EG12372-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12372-MONOMER COG COG0258 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0258 DIP DIP-11145N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11145N DOI 10.1006/jtbi.1994.1202 http://dx.doi.org/10.1006/jtbi.1994.1202 DOI 10.1016/S1568-7864(03)00135-6 http://dx.doi.org/10.1016/S1568-7864(03)00135-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/BJ20081637 http://dx.doi.org/10.1042/BJ20081637 DOI 10.1093/nar/17.12.4883 http://dx.doi.org/10.1093/nar/17.12.4883 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1093/nar/26.11.2593 http://dx.doi.org/10.1093/nar/26.11.2593 DOI 10.1093/nar/gkm396 http://dx.doi.org/10.1093/nar/gkm396 DOI 10.1093/nar/gkt591 http://dx.doi.org/10.1093/nar/gkt591 DOI 10.1111/j.1432-1033.1993.tb17718.x http://dx.doi.org/10.1111/j.1432-1033.1993.tb17718.x DOI 10.1111/j.1432-1033.1994.tb18938.x http://dx.doi.org/10.1111/j.1432-1033.1994.tb18938.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00653-07 http://dx.doi.org/10.1128/JB.00653-07 EC_number EC:3.1.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L07763 http://www.ebi.ac.uk/ena/data/view/L07763 EMBL M27177 http://www.ebi.ac.uk/ena/data/view/M27177 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 ENZYME 3.1.-.- http://enzyme.expasy.org/EC/3.1.-.- EchoBASE EB2275 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2275 EcoGene EG12372 http://www.ecogene.org/geneInfo.php?eg_id=EG12372 EnsemblBacteria AAC75840 http://www.ensemblgenomes.org/id/AAC75840 EnsemblBacteria AAC75840 http://www.ensemblgenomes.org/id/AAC75840 EnsemblBacteria BAE76870 http://www.ensemblgenomes.org/id/BAE76870 EnsemblBacteria BAE76870 http://www.ensemblgenomes.org/id/BAE76870 EnsemblBacteria BAE76870 http://www.ensemblgenomes.org/id/BAE76870 EnsemblBacteria b2798 http://www.ensemblgenomes.org/id/b2798 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0017108 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017108 GO_function GO:0030955 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030955 GO_process GO:0033567 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033567 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 Gene3D 3.40.50.1010 http://www.cathdb.info/version/latest/superfamily/3.40.50.1010 GeneID 947256 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947256 HAMAP MF_01192 http://hamap.expasy.org/unirule/MF_01192 HOGENOM HOG000040580 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000040580&db=HOGENOM6 InParanoid P38506 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P38506 IntAct P38506 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P38506* IntEnz 3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1 InterPro IPR002421 http://www.ebi.ac.uk/interpro/entry/IPR002421 InterPro IPR008918 http://www.ebi.ac.uk/interpro/entry/IPR008918 InterPro IPR020045 http://www.ebi.ac.uk/interpro/entry/IPR020045 InterPro IPR020046 http://www.ebi.ac.uk/interpro/entry/IPR020046 InterPro IPR022895 http://www.ebi.ac.uk/interpro/entry/IPR022895 InterPro IPR029060 http://www.ebi.ac.uk/interpro/entry/IPR029060 KEGG_Gene ecj:JW5446 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5446 KEGG_Gene eco:b2798 http://www.genome.jp/dbget-bin/www_bget?eco:b2798 KEGG_Orthology KO:K01146 http://www.genome.jp/dbget-bin/www_bget?KO:K01146 PDB 3ZD8 http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZD8 PDB 3ZD9 http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZD9 PDB 3ZDA http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZDA PDB 3ZDB http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZDB PDB 3ZDC http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZDC PDB 3ZDD http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZDD PDB 3ZDE http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZDE PDBsum 3ZD8 http://www.ebi.ac.uk/pdbsum/3ZD8 PDBsum 3ZD9 http://www.ebi.ac.uk/pdbsum/3ZD9 PDBsum 3ZDA http://www.ebi.ac.uk/pdbsum/3ZDA PDBsum 3ZDB http://www.ebi.ac.uk/pdbsum/3ZDB PDBsum 3ZDC http://www.ebi.ac.uk/pdbsum/3ZDC PDBsum 3ZDD http://www.ebi.ac.uk/pdbsum/3ZDD PDBsum 3ZDE http://www.ebi.ac.uk/pdbsum/3ZDE PSORT swissprot:XNI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:XNI_ECOLI PSORT-B swissprot:XNI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:XNI_ECOLI PSORT2 swissprot:XNI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:XNI_ECOLI Pfam PF01367 http://pfam.xfam.org/family/PF01367 Pfam PF02739 http://pfam.xfam.org/family/PF02739 Phobius swissprot:XNI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:XNI_ECOLI PhylomeDB P38506 http://phylomedb.org/?seqid=P38506 ProteinModelPortal P38506 http://www.proteinmodelportal.org/query/uniprot/P38506 PubMed 14599740 http://www.ncbi.nlm.nih.gov/pubmed/14599740 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17567612 http://www.ncbi.nlm.nih.gov/pubmed/17567612 PubMed 17905985 http://www.ncbi.nlm.nih.gov/pubmed/17905985 PubMed 19000038 http://www.ncbi.nlm.nih.gov/pubmed/19000038 PubMed 23821668 http://www.ncbi.nlm.nih.gov/pubmed/23821668 PubMed 2664711 http://www.ncbi.nlm.nih.gov/pubmed/2664711 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 7996866 http://www.ncbi.nlm.nih.gov/pubmed/7996866 PubMed 8026499 http://www.ncbi.nlm.nih.gov/pubmed/8026499 PubMed 8385012 http://www.ncbi.nlm.nih.gov/pubmed/8385012 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9592142 http://www.ncbi.nlm.nih.gov/pubmed/9592142 RefSeq NP_417278 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417278 RefSeq WP_000268232 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000268232 SMART SM00279 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00279 SMART SM00475 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00475 SMR P38506 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P38506 STRING 511145.b2798 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2798&targetmode=cogs STRING COG0258 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0258&targetmode=cogs SUPFAM SSF47807 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47807 SUPFAM SSF88723 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF88723 UniProtKB XNI_ECOLI http://www.uniprot.org/uniprot/XNI_ECOLI UniProtKB-AC P38506 http://www.uniprot.org/uniprot/P38506 charge swissprot:XNI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:XNI_ECOLI eggNOG COG0258 http://eggnogapi.embl.de/nog_data/html/tree/COG0258 eggNOG ENOG4105CIQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CIQ epestfind swissprot:XNI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:XNI_ECOLI garnier swissprot:XNI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:XNI_ECOLI helixturnhelix swissprot:XNI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:XNI_ECOLI hmoment swissprot:XNI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:XNI_ECOLI iep swissprot:XNI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:XNI_ECOLI inforesidue swissprot:XNI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:XNI_ECOLI octanol swissprot:XNI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:XNI_ECOLI pepcoil swissprot:XNI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:XNI_ECOLI pepdigest swissprot:XNI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:XNI_ECOLI pepinfo swissprot:XNI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:XNI_ECOLI pepnet swissprot:XNI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:XNI_ECOLI pepstats swissprot:XNI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:XNI_ECOLI pepwheel swissprot:XNI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:XNI_ECOLI pepwindow swissprot:XNI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:XNI_ECOLI sigcleave swissprot:XNI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:XNI_ECOLI ## Database ID URL or Descriptions # AltName INTD_ECOLI Prophage DLP12 integrase # AltName INTD_ECOLI Prophage QSR' integrase # BioGrid 4259881 12 # EcoGene EG10507 intD # FUNCTION INTD_ECOLI Integrase from the cryptic lambdoic prophage DLP12. Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_function GO:0008979 prophage integrase activity; ISS:EcoCyc. # GO_process GO:0006310 DNA recombination; IEA:UniProtKB-KW. # GO_process GO:0046718 viral entry into host cell; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0008150 biological_process # Gene3D 1.10.443.10 -; 1. # IntAct P24218 20 # InterPro IPR002104 Integrase_catalytic # InterPro IPR011010 DNA_brk_join_enz # InterPro IPR013762 Integrase-like_cat # MISCELLANEOUS INTD_ECOLI Encoded by the cryptic lambdoid prophage DLP12. # Organism INTD_ECOLI Escherichia coli (strain K12) # PATRIC 32116236 VBIEscCol129921_0558 # PIR A33497 A33497 # Pfam PF00589 Phage_integrase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Prophage integrase IntD {ECO 0000305} # RefSeq NP_415069 NC_000913.3 # RefSeq WP_001350488 NZ_LN832404.1 # SIMILARITY Belongs to the 'phage' integrase family. {ECO 0000305}. # SUPFAM SSF56349 SSF56349; 2 # eggNOG COG0582 LUCA # eggNOG ENOG4108KU3 Bacteria BLAST swissprot:INTD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INTD_ECOLI BioCyc ECOL316407:JW0525-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0525-MONOMER BioCyc EcoCyc:EG10507-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10507-MONOMER DOI 10.1007/BF00260503 http://dx.doi.org/10.1007/BF00260503 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M27155 http://www.ebi.ac.uk/ena/data/view/M27155 EMBL M31074 http://www.ebi.ac.uk/ena/data/view/M31074 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EMBL X51662 http://www.ebi.ac.uk/ena/data/view/X51662 EchoBASE EB0502 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0502 EcoGene EG10507 http://www.ecogene.org/geneInfo.php?eg_id=EG10507 EnsemblBacteria AAC73638 http://www.ensemblgenomes.org/id/AAC73638 EnsemblBacteria AAC73638 http://www.ensemblgenomes.org/id/AAC73638 EnsemblBacteria BAE76313 http://www.ensemblgenomes.org/id/BAE76313 EnsemblBacteria BAE76313 http://www.ensemblgenomes.org/id/BAE76313 EnsemblBacteria BAE76313 http://www.ensemblgenomes.org/id/BAE76313 EnsemblBacteria b0537 http://www.ensemblgenomes.org/id/b0537 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0008979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008979 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0046718 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046718 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.10.443.10 http://www.cathdb.info/version/latest/superfamily/1.10.443.10 GeneID 947162 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947162 HOGENOM HOG000227532 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000227532&db=HOGENOM6 InParanoid P24218 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P24218 IntAct P24218 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P24218* InterPro IPR002104 http://www.ebi.ac.uk/interpro/entry/IPR002104 InterPro IPR011010 http://www.ebi.ac.uk/interpro/entry/IPR011010 InterPro IPR013762 http://www.ebi.ac.uk/interpro/entry/IPR013762 KEGG_Gene ecj:JW0525 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0525 KEGG_Gene eco:b0537 http://www.genome.jp/dbget-bin/www_bget?eco:b0537 OMA AWIHADQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AWIHADQ PSORT swissprot:INTD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INTD_ECOLI PSORT-B swissprot:INTD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INTD_ECOLI PSORT2 swissprot:INTD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INTD_ECOLI Pfam PF00589 http://pfam.xfam.org/family/PF00589 Phobius swissprot:INTD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INTD_ECOLI PhylomeDB P24218 http://phylomedb.org/?seqid=P24218 ProteinModelPortal P24218 http://www.proteinmodelportal.org/query/uniprot/P24218 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2183007 http://www.ncbi.nlm.nih.gov/pubmed/2183007 PubMed 2553674 http://www.ncbi.nlm.nih.gov/pubmed/2553674 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415069 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415069 RefSeq WP_001350488 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001350488 SMR P24218 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P24218 STRING 511145.b0537 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0537&targetmode=cogs SUPFAM SSF56349 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56349 UniProtKB INTD_ECOLI http://www.uniprot.org/uniprot/INTD_ECOLI UniProtKB-AC P24218 http://www.uniprot.org/uniprot/P24218 charge swissprot:INTD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INTD_ECOLI eggNOG COG0582 http://eggnogapi.embl.de/nog_data/html/tree/COG0582 eggNOG ENOG4108KU3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108KU3 epestfind swissprot:INTD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INTD_ECOLI garnier swissprot:INTD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INTD_ECOLI helixturnhelix swissprot:INTD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INTD_ECOLI hmoment swissprot:INTD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INTD_ECOLI iep swissprot:INTD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INTD_ECOLI inforesidue swissprot:INTD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INTD_ECOLI octanol swissprot:INTD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INTD_ECOLI pepcoil swissprot:INTD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INTD_ECOLI pepdigest swissprot:INTD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INTD_ECOLI pepinfo swissprot:INTD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INTD_ECOLI pepnet swissprot:INTD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INTD_ECOLI pepstats swissprot:INTD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INTD_ECOLI pepwheel swissprot:INTD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INTD_ECOLI pepwindow swissprot:INTD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INTD_ECOLI sigcleave swissprot:INTD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INTD_ECOLI ## Database ID URL or Descriptions # EcoGene EG14401 ytcA # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR031381 YtcA # Organism YTCA_ECOLI Escherichia coli (strain K12) # PATRIC 32123719 VBIEscCol129921_4208 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF17090 Ytca # Proteomes UP000000625 Chromosome # RecName YTCA_ECOLI Uncharacterized protein YtcA # RefSeq WP_001295389 NZ_LN832404.1 # RefSeq YP_001165334 NC_000913.3 # SIMILARITY Belongs to the YtcA family. {ECO 0000305}. # SUBCELLULAR LOCATION YTCA_ECOLI Cell membrane {ECO 0000255|PROSITE- ProRule PRU00303}; Lipid-anchor {ECO 0000255|PROSITE- ProRule PRU00303}. Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # eggNOG ENOG4106833 Bacteria # eggNOG ENOG410XV8F LUCA BLAST swissprot:YTCA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YTCA_ECOLI BioCyc EcoCyc:MONOMER0-2830 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2830 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14401 http://www.ecogene.org/geneInfo.php?eg_id=EG14401 EnsemblBacteria ABP93459 http://www.ensemblgenomes.org/id/ABP93459 EnsemblBacteria ABP93459 http://www.ensemblgenomes.org/id/ABP93459 EnsemblBacteria b4622 http://www.ensemblgenomes.org/id/b4622 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 5061530 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5061530 HOGENOM HOG000009677 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009677&db=HOGENOM6 InterPro IPR031381 http://www.ebi.ac.uk/interpro/entry/IPR031381 KEGG_Gene eco:b4622 http://www.genome.jp/dbget-bin/www_bget?eco:b4622 OMA AFPGWFF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AFPGWFF PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YTCA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YTCA_ECOLI PSORT-B swissprot:YTCA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YTCA_ECOLI PSORT2 swissprot:YTCA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YTCA_ECOLI Pfam PF17090 http://pfam.xfam.org/family/PF17090 Phobius swissprot:YTCA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YTCA_ECOLI ProteinModelPortal A5A630 http://www.proteinmodelportal.org/query/uniprot/A5A630 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001295389 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295389 RefSeq YP_001165334 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001165334 STRING 511145.b4622 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4622&targetmode=cogs UniProtKB YTCA_ECOLI http://www.uniprot.org/uniprot/YTCA_ECOLI UniProtKB-AC A5A630 http://www.uniprot.org/uniprot/A5A630 charge swissprot:YTCA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YTCA_ECOLI eggNOG ENOG4106833 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106833 eggNOG ENOG410XV8F http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XV8F epestfind swissprot:YTCA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YTCA_ECOLI garnier swissprot:YTCA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YTCA_ECOLI helixturnhelix swissprot:YTCA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YTCA_ECOLI hmoment swissprot:YTCA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YTCA_ECOLI iep swissprot:YTCA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YTCA_ECOLI inforesidue swissprot:YTCA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YTCA_ECOLI octanol swissprot:YTCA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YTCA_ECOLI pepcoil swissprot:YTCA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YTCA_ECOLI pepdigest swissprot:YTCA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YTCA_ECOLI pepinfo swissprot:YTCA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YTCA_ECOLI pepnet swissprot:YTCA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YTCA_ECOLI pepstats swissprot:YTCA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YTCA_ECOLI pepwheel swissprot:YTCA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YTCA_ECOLI pepwindow swissprot:YTCA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YTCA_ECOLI sigcleave swissprot:YTCA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YTCA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261707 7 # EcoGene EG11225 dcuA # FUNCTION DCUA_ECOLI Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015556 C4-dicarboxylate transmembrane transporter activity; IEA:InterPro. # GO_process GO:0015740 C4-dicarboxylate transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR004668 Anaer_Dcu_memb_transpt # Organism DCUA_ECOLI Escherichia coli (strain K12) # PATRIC 32123843 VBIEscCol129921_4269 # PIR S56366 QQEC94 # PIRSF PIRSF004539 C4-dicrbxl_trns # Pfam PF03605 DcuA_DcuB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DCUA_ECOLI Anaerobic C4-dicarboxylate transporter DcuA # RefSeq NP_418561 NC_000913.3 # RefSeq WP_000961959 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAE78140.1; Type=Frameshift; Positions=60; Evidence={ECO 0000305}; # SIMILARITY Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family. {ECO 0000305}. # SUBCELLULAR LOCATION DCUA_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.13.1 the c4-dicarboxylate uptake (dcu) family # TIGRFAMs TIGR00770 Dcu # eggNOG COG2704 LUCA # eggNOG ENOG4105DS2 Bacteria BLAST swissprot:DCUA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DCUA_ECOLI BioCyc ECOL316407:JW5735-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5735-MONOMER BioCyc EcoCyc:DCUA-MONOMER http://biocyc.org/getid?id=EcoCyc:DCUA-MONOMER BioCyc MetaCyc:DCUA-MONOMER http://biocyc.org/getid?id=MetaCyc:DCUA-MONOMER COG COG2704 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2704 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2370547 http://dx.doi.org/10.1042/bj2370547 DOI 10.1042/bst021342s http://dx.doi.org/10.1042/bst021342s DOI 10.1093/nar/13.6.2063 http://dx.doi.org/10.1093/nar/13.6.2063 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X02307 http://www.ebi.ac.uk/ena/data/view/X02307 EMBL X04066 http://www.ebi.ac.uk/ena/data/view/X04066 EMBL X79887 http://www.ebi.ac.uk/ena/data/view/X79887 EchoBASE EB1207 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1207 EcoGene EG11225 http://www.ecogene.org/geneInfo.php?eg_id=EG11225 EnsemblBacteria AAC77098 http://www.ensemblgenomes.org/id/AAC77098 EnsemblBacteria AAC77098 http://www.ensemblgenomes.org/id/AAC77098 EnsemblBacteria BAE78140 http://www.ensemblgenomes.org/id/BAE78140 EnsemblBacteria BAE78140 http://www.ensemblgenomes.org/id/BAE78140 EnsemblBacteria BAE78140 http://www.ensemblgenomes.org/id/BAE78140 EnsemblBacteria b4138 http://www.ensemblgenomes.org/id/b4138 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015556 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015556 GO_process GO:0015740 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015740 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948659 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948659 HOGENOM HOG000272417 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000272417&db=HOGENOM6 InterPro IPR004668 http://www.ebi.ac.uk/interpro/entry/IPR004668 KEGG_Gene ecj:JW5735 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5735 KEGG_Gene eco:b4138 http://www.genome.jp/dbget-bin/www_bget?eco:b4138 KEGG_Orthology KO:K07791 http://www.genome.jp/dbget-bin/www_bget?KO:K07791 OMA PKQINYL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PKQINYL PSORT swissprot:DCUA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DCUA_ECOLI PSORT-B swissprot:DCUA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DCUA_ECOLI PSORT2 swissprot:DCUA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DCUA_ECOLI Pfam PF03605 http://pfam.xfam.org/family/PF03605 Phobius swissprot:DCUA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DCUA_ECOLI PhylomeDB P0ABN5 http://phylomedb.org/?seqid=P0ABN5 ProteinModelPortal P0ABN5 http://www.proteinmodelportal.org/query/uniprot/P0ABN5 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2656658 http://www.ncbi.nlm.nih.gov/pubmed/2656658 PubMed 2987841 http://www.ncbi.nlm.nih.gov/pubmed/2987841 PubMed 3541901 http://www.ncbi.nlm.nih.gov/pubmed/3541901 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 7961398 http://www.ncbi.nlm.nih.gov/pubmed/7961398 PubMed 8131924 http://www.ncbi.nlm.nih.gov/pubmed/8131924 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9733683 http://www.ncbi.nlm.nih.gov/pubmed/9733683 RefSeq NP_418561 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418561 RefSeq WP_000961959 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000961959 STRING 511145.b4138 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4138&targetmode=cogs STRING COG2704 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2704&targetmode=cogs TCDB 2.A.13.1 http://www.tcdb.org/search/result.php?tc=2.A.13.1 TIGRFAMs TIGR00770 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00770 UniProtKB DCUA_ECOLI http://www.uniprot.org/uniprot/DCUA_ECOLI UniProtKB-AC P0ABN5 http://www.uniprot.org/uniprot/P0ABN5 charge swissprot:DCUA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DCUA_ECOLI eggNOG COG2704 http://eggnogapi.embl.de/nog_data/html/tree/COG2704 eggNOG ENOG4105DS2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DS2 epestfind swissprot:DCUA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DCUA_ECOLI garnier swissprot:DCUA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DCUA_ECOLI helixturnhelix swissprot:DCUA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DCUA_ECOLI hmoment swissprot:DCUA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DCUA_ECOLI iep swissprot:DCUA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DCUA_ECOLI inforesidue swissprot:DCUA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DCUA_ECOLI octanol swissprot:DCUA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DCUA_ECOLI pepcoil swissprot:DCUA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DCUA_ECOLI pepdigest swissprot:DCUA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DCUA_ECOLI pepinfo swissprot:DCUA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DCUA_ECOLI pepnet swissprot:DCUA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DCUA_ECOLI pepstats swissprot:DCUA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DCUA_ECOLI pepwheel swissprot:DCUA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DCUA_ECOLI pepwindow swissprot:DCUA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DCUA_ECOLI sigcleave swissprot:DCUA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DCUA_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES MENB_ECOLI Kinetic parameters KM=26 uM for o-succinylbenzoyl-CoA {ECO 0000269|PubMed 21830810}; KM=2.8 uM for o-succinylbenzoyl-CoA {ECO 0000269|PubMed 23658663}; Note=kcat is 620 sec(-1) with o-succinylbenzoyl-CoA as substrate(PubMed 21830810). kcat is 1.24 min(-1) with o- succinylbenzoyl-CoA as substrate (PubMed 23658663). All assays are performed at pH 7.0 at 25 degrees Celsius and in the presence of 20 mM NaHCO(3). {ECO 0000269|PubMed 21830810, ECO 0000269|PubMed 23658663}; # BioGrid 4260504 14 # CATALYTIC ACTIVITY MENB_ECOLI 4-(2-carboxyphenyl)-4-oxobutanoyl-CoA = 1,4- dihydroxy-2-naphthoyl-CoA + H(2)O. {ECO 0000255|HAMAP- Rule MF_01934, ECO 0000269|PubMed 20643650, ECO 0000269|PubMed 21830810, ECO 0000269|PubMed 22606952, ECO 0000269|PubMed 23658663}. # COFACTOR MENB_ECOLI Name=hydrogencarbonate; Xref=ChEBI CHEBI 17544; Evidence={ECO 0000255|HAMAP-Rule MF_01934, ECO 0000269|PubMed 20643650, ECO 0000305|PubMed 22606952}; Note=The hydrogencarbonate anion plays the same catalytic role (proton acceptor) as the side-chain carboxylate group of the essential 'Asp-185' found in actinobacteria, archaea, bacteroidetes, and deltaproteobacteria. {ECO 0000269|PubMed 20643650, ECO 0000305|PubMed 22606952}; # ENZYME REGULATION Inhibited by sulfite and nitrate. {ECO:0000269|PubMed 20643650}. # EcoGene EG11368 menB # FUNCTION MENB_ECOLI Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA). {ECO 0000255|HAMAP- Rule MF_01934, ECO 0000269|PubMed 1091286, ECO 0000269|PubMed 20643650, ECO 0000269|PubMed 21830810, ECO 0000269|PubMed 23658663}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008935 1,4-dihydroxy-2-naphthoyl-CoA synthase activity; IDA:EcoliWiki. # GO_function GO:0071890 bicarbonate binding; IDA:UniProtKB. # GO_process GO:0009234 menaquinone biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 1.10.12.10 -; 1. # Gene3D 3.90.226.10 -; 1. # HAMAP MF_01934 MenB # INTERACTION MENB_ECOLI P67910 hldD; NbExp=2; IntAct=EBI-554195, EBI-543760; # IntAct P0ABU0 6 # InterPro IPR001753 Crotonase_core_superfam # InterPro IPR010198 DHNA-CoA_synthase_MenB # InterPro IPR014748 Crontonase_C # InterPro IPR018376 Enoyl-CoA_hyd/isom_CS # InterPro IPR029045 ClpP/crotonase-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00130 Ubiquinone and other terpenoid-quinone biosynthesis # Organism MENB_ECOLI Escherichia coli (strain K12) # PATHWAY Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 6/7. {ECO 0000255|HAMAP-Rule:MF_01934}. # PATHWAY Quinol/quinone metabolism; menaquinone biosynthesis. {ECO:0000255|HAMAP-Rule MF_01934}. # PATRIC 32119891 VBIEscCol129921_2355 # PDB 3T88 X-ray; 2.00 A; A/B/C/D/E/F=1-285 # PDB 3T89 X-ray; 1.95 A; A/B/C/D/E/F=1-285 # PDB 4ELS X-ray; 2.30 A; A/B/C/D/E/F=1-285 # PDB 4ELW X-ray; 2.55 A; A/B/C/D/E/F=1-285 # PDB 4ELX X-ray; 2.19 A; A/B/C/D/E/F=1-285 # PDB 4I42 X-ray; 1.85 A; A/B/C/D/E/F/G/H/I/J/K/L=1-285 # PIR A42714 D64997 # PROSITE PS00166 ENOYL_COA_HYDRATASE # Pfam PF00378 ECH_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MENB_ECOLI 1,4-dihydroxy-2-naphthoyl-CoA synthase {ECO 0000255|HAMAP-Rule MF_01934, ECO 0000303|PubMed 21830810} # RefSeq NP_416765 NC_000913.3 # RefSeq WP_000639996 NZ_LN832404.1 # SIMILARITY Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily. {ECO:0000255|HAMAP-Rule MF_01934}. # SUBUNIT MENB_ECOLI Homohexamer. Dimer of a homotrimer. {ECO 0000269|PubMed 20643650, ECO 0000269|PubMed 21830810, ECO 0000269|PubMed 22606952, ECO 0000269|PubMed 23658663}. # SUPFAM SSF52096 SSF52096 # TIGRFAMs TIGR01929 menB # UniPathway UPA01057 UER00167 # eggNOG COG0447 LUCA # eggNOG ENOG4108IPT Bacteria BLAST swissprot:MENB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MENB_ECOLI BioCyc ECOL316407:JW2257-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2257-MONOMER BioCyc EcoCyc:NAPHTHOATE-SYN-MONOMER http://biocyc.org/getid?id=EcoCyc:NAPHTHOATE-SYN-MONOMER BioCyc MetaCyc:NAPHTHOATE-SYN-MONOMER http://biocyc.org/getid?id=MetaCyc:NAPHTHOATE-SYN-MONOMER COG COG0447 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0447 DIP DIP-47854N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47854N DOI 10.1021/bi00673a029 http://dx.doi.org/10.1021/bi00673a029 DOI 10.1021/bi200877x http://dx.doi.org/10.1021/bi200877x DOI 10.1021/bi300486j http://dx.doi.org/10.1021/bi300486j DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M110.147702 http://dx.doi.org/10.1074/jbc.M110.147702 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pone.0063095 http://dx.doi.org/10.1371/journal.pone.0063095 EC_number EC:4.1.3.36 {ECO:0000255|HAMAP-Rule:MF_01934, ECO:0000269|PubMed:20643650, ECO:0000269|PubMed:21830810, ECO:0000269|PubMed:22606952, ECO:0000269|PubMed:23658663} http://www.genome.jp/dbget-bin/www_bget?EC:4.1.3.36 {ECO:0000255|HAMAP-Rule:MF_01934, ECO:0000269|PubMed:20643650, ECO:0000269|PubMed:21830810, ECO:0000269|PubMed:22606952, ECO:0000269|PubMed:23658663} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L35030 http://www.ebi.ac.uk/ena/data/view/L35030 EMBL M93421 http://www.ebi.ac.uk/ena/data/view/M93421 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 4.1.3.36 {ECO:0000255|HAMAP-Rule:MF_01934, ECO:0000269|PubMed:20643650, ECO:0000269|PubMed:21830810, ECO:0000269|PubMed:22606952, ECO:0000269|PubMed:23658663} http://enzyme.expasy.org/EC/4.1.3.36 {ECO:0000255|HAMAP-Rule:MF_01934, ECO:0000269|PubMed:20643650, ECO:0000269|PubMed:21830810, ECO:0000269|PubMed:22606952, ECO:0000269|PubMed:23658663} EchoBASE EB1342 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1342 EcoGene EG11368 http://www.ecogene.org/geneInfo.php?eg_id=EG11368 EnsemblBacteria AAC75322 http://www.ensemblgenomes.org/id/AAC75322 EnsemblBacteria AAC75322 http://www.ensemblgenomes.org/id/AAC75322 EnsemblBacteria BAA16086 http://www.ensemblgenomes.org/id/BAA16086 EnsemblBacteria BAA16086 http://www.ensemblgenomes.org/id/BAA16086 EnsemblBacteria BAA16086 http://www.ensemblgenomes.org/id/BAA16086 EnsemblBacteria b2262 http://www.ensemblgenomes.org/id/b2262 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008935 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008935 GO_function GO:0071890 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071890 GO_process GO:0009234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009234 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 1.10.12.10 http://www.cathdb.info/version/latest/superfamily/1.10.12.10 Gene3D 3.90.226.10 http://www.cathdb.info/version/latest/superfamily/3.90.226.10 GeneID 946747 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946747 HAMAP MF_01934 http://hamap.expasy.org/unirule/MF_01934 HOGENOM HOG000027942 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000027942&db=HOGENOM6 InParanoid P0ABU0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABU0 IntAct P0ABU0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABU0* IntEnz 4.1.3.36 {ECO:0000255|HAMAP-Rule:MF_01934, ECO:0000269|PubMed:20643650, ECO:0000269|PubMed:21830810, ECO:0000269|PubMed:22606952, ECO:0000269|PubMed:23658663} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.3.36 {ECO:0000255|HAMAP-Rule:MF_01934, ECO:0000269|PubMed:20643650, ECO:0000269|PubMed:21830810, ECO:0000269|PubMed:22606952, ECO:0000269|PubMed:23658663} InterPro IPR001753 http://www.ebi.ac.uk/interpro/entry/IPR001753 InterPro IPR010198 http://www.ebi.ac.uk/interpro/entry/IPR010198 InterPro IPR014748 http://www.ebi.ac.uk/interpro/entry/IPR014748 InterPro IPR018376 http://www.ebi.ac.uk/interpro/entry/IPR018376 InterPro IPR029045 http://www.ebi.ac.uk/interpro/entry/IPR029045 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2257 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2257 KEGG_Gene eco:b2262 http://www.genome.jp/dbget-bin/www_bget?eco:b2262 KEGG_Orthology KO:K01661 http://www.genome.jp/dbget-bin/www_bget?KO:K01661 KEGG_Pathway ko00130 http://www.genome.jp/kegg-bin/show_pathway?ko00130 KEGG_Reaction rn:R07263 http://www.genome.jp/dbget-bin/www_bget?rn:R07263 MINT MINT-1227416 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1227416 OMA KYAFCSG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KYAFCSG PDB 3T88 http://www.ebi.ac.uk/pdbe-srv/view/entry/3T88 PDB 3T89 http://www.ebi.ac.uk/pdbe-srv/view/entry/3T89 PDB 4ELS http://www.ebi.ac.uk/pdbe-srv/view/entry/4ELS PDB 4ELW http://www.ebi.ac.uk/pdbe-srv/view/entry/4ELW PDB 4ELX http://www.ebi.ac.uk/pdbe-srv/view/entry/4ELX PDB 4I42 http://www.ebi.ac.uk/pdbe-srv/view/entry/4I42 PDBsum 3T88 http://www.ebi.ac.uk/pdbsum/3T88 PDBsum 3T89 http://www.ebi.ac.uk/pdbsum/3T89 PDBsum 4ELS http://www.ebi.ac.uk/pdbsum/4ELS PDBsum 4ELW http://www.ebi.ac.uk/pdbsum/4ELW PDBsum 4ELX http://www.ebi.ac.uk/pdbsum/4ELX PDBsum 4I42 http://www.ebi.ac.uk/pdbsum/4I42 PROSITE PS00166 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00166 PSORT swissprot:MENB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MENB_ECOLI PSORT-B swissprot:MENB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MENB_ECOLI PSORT2 swissprot:MENB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MENB_ECOLI Pfam PF00378 http://pfam.xfam.org/family/PF00378 Phobius swissprot:MENB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MENB_ECOLI PhylomeDB P0ABU0 http://phylomedb.org/?seqid=P0ABU0 ProteinModelPortal P0ABU0 http://www.proteinmodelportal.org/query/uniprot/P0ABU0 PubMed 1091286 http://www.ncbi.nlm.nih.gov/pubmed/1091286 PubMed 1629162 http://www.ncbi.nlm.nih.gov/pubmed/1629162 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20643650 http://www.ncbi.nlm.nih.gov/pubmed/20643650 PubMed 21830810 http://www.ncbi.nlm.nih.gov/pubmed/21830810 PubMed 22606952 http://www.ncbi.nlm.nih.gov/pubmed/22606952 PubMed 23658663 http://www.ncbi.nlm.nih.gov/pubmed/23658663 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416765 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416765 RefSeq WP_000639996 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000639996 SMR P0ABU0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABU0 STRING 511145.b2262 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2262&targetmode=cogs STRING COG0447 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0447&targetmode=cogs SUPFAM SSF52096 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52096 TIGRFAMs TIGR01929 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01929 UniProtKB MENB_ECOLI http://www.uniprot.org/uniprot/MENB_ECOLI UniProtKB-AC P0ABU0 http://www.uniprot.org/uniprot/P0ABU0 charge swissprot:MENB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MENB_ECOLI eggNOG COG0447 http://eggnogapi.embl.de/nog_data/html/tree/COG0447 eggNOG ENOG4108IPT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108IPT epestfind swissprot:MENB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MENB_ECOLI garnier swissprot:MENB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MENB_ECOLI helixturnhelix swissprot:MENB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MENB_ECOLI hmoment swissprot:MENB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MENB_ECOLI iep swissprot:MENB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MENB_ECOLI inforesidue swissprot:MENB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MENB_ECOLI octanol swissprot:MENB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MENB_ECOLI pepcoil swissprot:MENB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MENB_ECOLI pepdigest swissprot:MENB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MENB_ECOLI pepinfo swissprot:MENB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MENB_ECOLI pepnet swissprot:MENB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MENB_ECOLI pepstats swissprot:MENB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MENB_ECOLI pepwheel swissprot:MENB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MENB_ECOLI pepwindow swissprot:MENB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MENB_ECOLI sigcleave swissprot:MENB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MENB_ECOLI ## Database ID URL or Descriptions # AltName NUOI_ECOLI NADH dehydrogenase I subunit I # AltName NUOI_ECOLI NDH-1 subunit I # AltName NUOI_ECOLI NUO9 # CATALYTIC ACTIVITY NUOI_ECOLI NADH + a quinone = NAD(+) + a quinol. # COFACTOR NUOI_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000250}; Note=Binds 2 [4Fe-4S] clusters per subunit. {ECO 0000250}; # EcoGene EG12089 nuoI # FUNCTION NUOI_ECOLI NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0030964 NADH dehydrogenase complex; IDA:EcoliWiki. # GO_component GO:0045272 plasma membrane respiratory chain complex I; IDA:EcoCyc. # GO_function GO:0005506 iron ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0048038 quinone binding; IEA:UniProtKB-KW. # GO_function GO:0050136 NADH dehydrogenase (quinone) activity; IEA:UniProtKB-HAMAP. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IDA:EcoCyc. # GO_process GO:0009060 aerobic respiration; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # HAMAP MF_01351 NDH1_NuoI # IntAct P0AFD6 7 # InterPro IPR010226 NADH_quinone_OxRdtase_chainI # InterPro IPR017896 4Fe4S_Fe-S-bd # InterPro IPR017900 4Fe4S_Fe_S_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00190 Oxidative phosphorylation # KEGG_Pathway ko00910 Nitrogen metabolism # Organism NUOI_ECOLI Escherichia coli (strain K12) # PATRIC 32119929 VBIEscCol129921_2374 # PIR G64999 G64999 # PROSITE PS00198 4FE4S_FER_1; 2 # PROSITE PS51379 4FE4S_FER_2; 2 # Pfam PF12838 Fer4_7 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NUOI_ECOLI NADH-quinone oxidoreductase subunit I # RefSeq NP_416784 NC_000913.3 # RefSeq WP_000172749 NZ_LN832404.1 # SIMILARITY Belongs to the complex I 23 kDa subunit family. {ECO 0000305}. # SIMILARITY Contains 2 4Fe-4S ferredoxin-type domains. {ECO 0000305}. # SUBCELLULAR LOCATION NUOI_ECOLI Cell inner membrane {ECO 0000305}; Peripheral membrane protein {ECO 0000305}. # SUBUNIT NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex (By similarity). {ECO 0000250}. # TCDB 3.D.1.1 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family # TIGRFAMs TIGR01971 NuoI # eggNOG COG1143 LUCA BLAST swissprot:NUOI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NUOI_ECOLI BioCyc ECOL316407:JW2276-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2276-MONOMER BioCyc EcoCyc:NUOI-MONOMER http://biocyc.org/getid?id=EcoCyc:NUOI-MONOMER BioCyc MetaCyc:NUOI-MONOMER http://biocyc.org/getid?id=MetaCyc:NUOI-MONOMER COG COG1143 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1143 DIP DIP-35918N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35918N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1993.1488 http://dx.doi.org/10.1006/jmbi.1993.1488 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1432-1033.1995.tb20594.x http://dx.doi.org/10.1111/j.1432-1033.1995.tb20594.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.6.5.11 http://www.genome.jp/dbget-bin/www_bget?EC:1.6.5.11 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X68301 http://www.ebi.ac.uk/ena/data/view/X68301 ENZYME 1.6.5.11 http://enzyme.expasy.org/EC/1.6.5.11 EchoBASE EB2013 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2013 EcoGene EG12089 http://www.ecogene.org/geneInfo.php?eg_id=EG12089 EnsemblBacteria AAC75341 http://www.ensemblgenomes.org/id/AAC75341 EnsemblBacteria AAC75341 http://www.ensemblgenomes.org/id/AAC75341 EnsemblBacteria BAA16109 http://www.ensemblgenomes.org/id/BAA16109 EnsemblBacteria BAA16109 http://www.ensemblgenomes.org/id/BAA16109 EnsemblBacteria BAA16109 http://www.ensemblgenomes.org/id/BAA16109 EnsemblBacteria b2281 http://www.ensemblgenomes.org/id/b2281 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0030964 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030964 GO_component GO:0045272 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045272 GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0048038 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048038 GO_function GO:0050136 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050136 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0009060 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009060 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GeneID 946757 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946757 HAMAP MF_01351 http://hamap.expasy.org/unirule/MF_01351 HOGENOM HOG000228291 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000228291&db=HOGENOM6 InParanoid P0AFD6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFD6 IntAct P0AFD6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFD6* IntEnz 1.6.5.11 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.6.5.11 InterPro IPR010226 http://www.ebi.ac.uk/interpro/entry/IPR010226 InterPro IPR017896 http://www.ebi.ac.uk/interpro/entry/IPR017896 InterPro IPR017900 http://www.ebi.ac.uk/interpro/entry/IPR017900 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2276 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2276 KEGG_Gene eco:b2281 http://www.genome.jp/dbget-bin/www_bget?eco:b2281 KEGG_Orthology KO:K00338 http://www.genome.jp/dbget-bin/www_bget?KO:K00338 KEGG_Pathway ko00190 http://www.genome.jp/kegg-bin/show_pathway?ko00190 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Reaction rn:R02166 http://www.genome.jp/dbget-bin/www_bget?rn:R02166 OMA WYPDFFR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WYPDFFR PROSITE PS00198 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00198 PROSITE PS51379 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51379 PSORT swissprot:NUOI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NUOI_ECOLI PSORT-B swissprot:NUOI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NUOI_ECOLI PSORT2 swissprot:NUOI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NUOI_ECOLI Pfam PF12838 http://pfam.xfam.org/family/PF12838 Phobius swissprot:NUOI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NUOI_ECOLI PhylomeDB P0AFD6 http://phylomedb.org/?seqid=P0AFD6 ProteinModelPortal P0AFD6 http://www.proteinmodelportal.org/query/uniprot/P0AFD6 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7607227 http://www.ncbi.nlm.nih.gov/pubmed/7607227 PubMed 7690854 http://www.ncbi.nlm.nih.gov/pubmed/7690854 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_416784 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416784 RefSeq WP_000172749 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000172749 STRING 511145.b2281 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2281&targetmode=cogs STRING COG1143 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1143&targetmode=cogs TCDB 3.D.1.1 http://www.tcdb.org/search/result.php?tc=3.D.1.1 TIGRFAMs TIGR01971 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01971 UniProtKB NUOI_ECOLI http://www.uniprot.org/uniprot/NUOI_ECOLI UniProtKB-AC P0AFD6 http://www.uniprot.org/uniprot/P0AFD6 charge swissprot:NUOI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NUOI_ECOLI eggNOG COG1143 http://eggnogapi.embl.de/nog_data/html/tree/COG1143 epestfind swissprot:NUOI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NUOI_ECOLI garnier swissprot:NUOI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NUOI_ECOLI helixturnhelix swissprot:NUOI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NUOI_ECOLI hmoment swissprot:NUOI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NUOI_ECOLI iep swissprot:NUOI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NUOI_ECOLI inforesidue swissprot:NUOI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NUOI_ECOLI octanol swissprot:NUOI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NUOI_ECOLI pepcoil swissprot:NUOI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NUOI_ECOLI pepdigest swissprot:NUOI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NUOI_ECOLI pepinfo swissprot:NUOI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NUOI_ECOLI pepnet swissprot:NUOI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NUOI_ECOLI pepstats swissprot:NUOI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NUOI_ECOLI pepwheel swissprot:NUOI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NUOI_ECOLI pepwindow swissprot:NUOI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NUOI_ECOLI sigcleave swissprot:NUOI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NUOI_ECOLI ## Database ID URL or Descriptions # BioGrid 4260428 159 # EcoGene EG14059 yegP # Gene3D 3.30.160.160 -; 2. # InterPro IPR010879 DUF1508 # Organism YEGP_ECOLI Escherichia coli (strain K12) # PATRIC 32119495 VBIEscCol129921_2158 # PDB 2K8E NMR; -; A=1-110 # PIR G64974 G64974 # Pfam PF07411 DUF1508; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEGP_ECOLI UPF0339 protein YegP # RefSeq NP_416584 NC_000913.3 # RefSeq WP_001350529 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0339 family. Duplicated subfamily. {ECO 0000305}. # SUPFAM SSF160113 SSF160113; 2 # eggNOG COG3422 LUCA # eggNOG ENOG4105KWI Bacteria BLAST swissprot:YEGP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEGP_ECOLI BioCyc ECOL316407:JW5339-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5339-MONOMER BioCyc EcoCyc:G7117-MONOMER http://biocyc.org/getid?id=EcoCyc:G7117-MONOMER COG COG3422 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3422 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3812 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3812 EcoGene EG14059 http://www.ecogene.org/geneInfo.php?eg_id=EG14059 EnsemblBacteria AAC75141 http://www.ensemblgenomes.org/id/AAC75141 EnsemblBacteria AAC75141 http://www.ensemblgenomes.org/id/AAC75141 EnsemblBacteria BAE76581 http://www.ensemblgenomes.org/id/BAE76581 EnsemblBacteria BAE76581 http://www.ensemblgenomes.org/id/BAE76581 EnsemblBacteria BAE76581 http://www.ensemblgenomes.org/id/BAE76581 EnsemblBacteria b2080 http://www.ensemblgenomes.org/id/b2080 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.30.160.160 http://www.cathdb.info/version/latest/superfamily/3.30.160.160 GeneID 947095 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947095 HOGENOM HOG000255655 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000255655&db=HOGENOM6 InParanoid P76402 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76402 InterPro IPR010879 http://www.ebi.ac.uk/interpro/entry/IPR010879 KEGG_Gene ecj:JW5339 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5339 KEGG_Gene eco:b2080 http://www.genome.jp/dbget-bin/www_bget?eco:b2080 KEGG_Orthology KO:K09946 http://www.genome.jp/dbget-bin/www_bget?KO:K09946 OMA AANHQVI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AANHQVI PDB 2K8E http://www.ebi.ac.uk/pdbe-srv/view/entry/2K8E PDBsum 2K8E http://www.ebi.ac.uk/pdbsum/2K8E PSORT swissprot:YEGP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEGP_ECOLI PSORT-B swissprot:YEGP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEGP_ECOLI PSORT2 swissprot:YEGP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEGP_ECOLI Pfam PF07411 http://pfam.xfam.org/family/PF07411 Phobius swissprot:YEGP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEGP_ECOLI ProteinModelPortal P76402 http://www.proteinmodelportal.org/query/uniprot/P76402 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416584 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416584 RefSeq WP_001350529 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001350529 SMR P76402 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76402 STRING 511145.b2080 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2080&targetmode=cogs STRING COG3422 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3422&targetmode=cogs SUPFAM SSF160113 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF160113 UniProtKB YEGP_ECOLI http://www.uniprot.org/uniprot/YEGP_ECOLI UniProtKB-AC P76402 http://www.uniprot.org/uniprot/P76402 charge swissprot:YEGP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEGP_ECOLI eggNOG COG3422 http://eggnogapi.embl.de/nog_data/html/tree/COG3422 eggNOG ENOG4105KWI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KWI epestfind swissprot:YEGP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEGP_ECOLI garnier swissprot:YEGP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEGP_ECOLI helixturnhelix swissprot:YEGP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEGP_ECOLI hmoment swissprot:YEGP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEGP_ECOLI iep swissprot:YEGP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEGP_ECOLI inforesidue swissprot:YEGP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEGP_ECOLI octanol swissprot:YEGP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEGP_ECOLI pepcoil swissprot:YEGP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEGP_ECOLI pepdigest swissprot:YEGP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEGP_ECOLI pepinfo swissprot:YEGP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEGP_ECOLI pepnet swissprot:YEGP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEGP_ECOLI pepstats swissprot:YEGP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEGP_ECOLI pepwheel swissprot:YEGP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEGP_ECOLI pepwindow swissprot:YEGP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEGP_ECOLI sigcleave swissprot:YEGP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEGP_ECOLI ## Database ID URL or Descriptions # AltName COHE_ECOLI Putative lambdoid prophage e14 repressor protein C2 # EcoGene EG14249 cohE # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 2.10.109.10 -; 1. # InterPro IPR015927 Peptidase_S24_S26A/B/C # InterPro IPR019759 Peptidase_S24_S26 # InterPro IPR028360 Peptidase_S24/S26_b-rbn # MISCELLANEOUS COHE_ECOLI This protein is part of the e14 prophage present on the genomes of E.coli K12 MG1655 and W3110. # Organism COHE_ECOLI Escherichia coli (strain K12) # PATRIC 32117529 VBIEscCol129921_1187 # PIR F64859 F64859 # Pfam PF00717 Peptidase_S24 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Prophage repressor CohE {ECO 0000305} # RefSeq NP_415663 NC_000913.3 # RefSeq WP_000848748 NZ_CP010440.1 # SUPFAM SSF51306 SSF51306 # eggNOG COG1974 LUCA # eggNOG ENOG4105RDA Bacteria BLAST swissprot:COHE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:COHE_ECOLI BioCyc ECOL316407:JW1131-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1131-MONOMER BioCyc EcoCyc:G6589-MONOMER http://biocyc.org/getid?id=EcoCyc:G6589-MONOMER DIP DIP-12721N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12721N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3997 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3997 EcoGene EG14249 http://www.ecogene.org/geneInfo.php?eg_id=EG14249 EnsemblBacteria AAC74229 http://www.ensemblgenomes.org/id/AAC74229 EnsemblBacteria AAC74229 http://www.ensemblgenomes.org/id/AAC74229 EnsemblBacteria BAA35971 http://www.ensemblgenomes.org/id/BAA35971 EnsemblBacteria BAA35971 http://www.ensemblgenomes.org/id/BAA35971 EnsemblBacteria BAA35971 http://www.ensemblgenomes.org/id/BAA35971 EnsemblBacteria b1145 http://www.ensemblgenomes.org/id/b1145 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 2.10.109.10 http://www.cathdb.info/version/latest/superfamily/2.10.109.10 GeneID 945719 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945719 HOGENOM HOG000006606 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006606&db=HOGENOM6 InParanoid P75974 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75974 InterPro IPR015927 http://www.ebi.ac.uk/interpro/entry/IPR015927 InterPro IPR019759 http://www.ebi.ac.uk/interpro/entry/IPR019759 InterPro IPR028360 http://www.ebi.ac.uk/interpro/entry/IPR028360 KEGG_Gene ecj:JW1131 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1131 KEGG_Gene eco:b1145 http://www.genome.jp/dbget-bin/www_bget?eco:b1145 OMA DEEATIC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DEEATIC PSORT swissprot:COHE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:COHE_ECOLI PSORT-B swissprot:COHE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:COHE_ECOLI PSORT2 swissprot:COHE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:COHE_ECOLI Pfam PF00717 http://pfam.xfam.org/family/PF00717 Phobius swissprot:COHE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:COHE_ECOLI PhylomeDB P75974 http://phylomedb.org/?seqid=P75974 ProteinModelPortal P75974 http://www.proteinmodelportal.org/query/uniprot/P75974 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415663 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415663 RefSeq WP_000848748 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000848748 SMR P75974 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75974 STRING 511145.b1145 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1145&targetmode=cogs SUPFAM SSF51306 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51306 UniProtKB COHE_ECOLI http://www.uniprot.org/uniprot/COHE_ECOLI UniProtKB-AC P75974 http://www.uniprot.org/uniprot/P75974 charge swissprot:COHE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:COHE_ECOLI eggNOG COG1974 http://eggnogapi.embl.de/nog_data/html/tree/COG1974 eggNOG ENOG4105RDA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105RDA epestfind swissprot:COHE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:COHE_ECOLI garnier swissprot:COHE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:COHE_ECOLI helixturnhelix swissprot:COHE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:COHE_ECOLI hmoment swissprot:COHE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:COHE_ECOLI iep swissprot:COHE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:COHE_ECOLI inforesidue swissprot:COHE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:COHE_ECOLI octanol swissprot:COHE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:COHE_ECOLI pepcoil swissprot:COHE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:COHE_ECOLI pepdigest swissprot:COHE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:COHE_ECOLI pepinfo swissprot:COHE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:COHE_ECOLI pepnet swissprot:COHE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:COHE_ECOLI pepstats swissprot:COHE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:COHE_ECOLI pepwheel swissprot:COHE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:COHE_ECOLI pepwindow swissprot:COHE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:COHE_ECOLI sigcleave swissprot:COHE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:COHE_ECOLI ## Database ID URL or Descriptions # AltName NUOF_ECOLI NADH dehydrogenase I subunit F # AltName NUOF_ECOLI NDH-1 subunit F # AltName NUOF_ECOLI NUO6 # BioGrid 4260513 24 # CATALYTIC ACTIVITY NUOF_ECOLI NADH + a quinone = NAD(+) + a quinol. # COFACTOR NUOF_ECOLI Name=FMN; Xref=ChEBI CHEBI 58210; Evidence={ECO 0000305}; Note=Binds 1 FMN. {ECO 0000305}; # COFACTOR NUOF_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000305}; Note=Binds 1 [4Fe-4S] cluster. {ECO 0000305}; # EcoGene EG11774 nuoF # FUNCTION NUOF_ECOLI NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. # GO_component GO:0005886 plasma membrane; IDA:EcoliWiki. # GO_component GO:0030964 NADH dehydrogenase complex; IDA:EcoliWiki. # GO_component GO:0045272 plasma membrane respiratory chain complex I; IDA:EcoCyc. # GO_function GO:0008137 NADH dehydrogenase (ubiquinone) activity; IEA:InterPro. # GO_function GO:0010181 FMN binding; ISS:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0048038 quinone binding; IEA:UniProtKB-KW. # GO_function GO:0051287 NAD binding; IMP:EcoCyc. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IMP:EcoCyc. # GO_process GO:0009060 aerobic respiration; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # IntAct P31979 7 # InterPro IPR001949 NADH-UbQ_OxRdtase_51kDa_CS # InterPro IPR011537 NADH-UbQ_OxRdtase_suF # InterPro IPR011538 Nuo51_FMN-bd # InterPro IPR019554 Soluble_ligand-bd # InterPro IPR019575 Nuop51_4Fe4S-bd # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00190 Oxidative phosphorylation # KEGG_Pathway ko00910 Nitrogen metabolism # Organism NUOF_ECOLI Escherichia coli (strain K12) # PATRIC 32119935 VBIEscCol129921_2377 # PIR B65000 B65000 # PROSITE PS00644 COMPLEX1_51K_1 # PROSITE PS00645 COMPLEX1_51K_2 # Pfam PF01512 Complex1_51K # Pfam PF10531 SLBB # Pfam PF10589 NADH_4Fe-4S # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NUOF_ECOLI NADH-quinone oxidoreductase subunit F # RefSeq NP_416787 NC_000913.3 # RefSeq WP_000789500 NZ_LN832404.1 # SIMILARITY Belongs to the complex I 51 kDa subunit family. {ECO 0000305}. # SMART SM00928 NADH_4Fe-4S # SUBUNIT NUOF_ECOLI Composed of 13 different subunits. Subunits NuoCD, E, F, and G constitute the peripheral sector of the complex. # TCDB 3.D.1.1 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family # TIGRFAMs TIGR01959 nuoF_fam # eggNOG COG1894 LUCA # eggNOG ENOG4107QIZ Bacteria BLAST swissprot:NUOF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NUOF_ECOLI BioCyc ECOL316407:JW2279-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2279-MONOMER BioCyc EcoCyc:NUOF-MONOMER http://biocyc.org/getid?id=EcoCyc:NUOF-MONOMER BioCyc MetaCyc:NUOF-MONOMER http://biocyc.org/getid?id=MetaCyc:NUOF-MONOMER COG COG1894 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1894 DIP DIP-10382N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10382N DOI 10.1006/jmbi.1993.1488 http://dx.doi.org/10.1006/jmbi.1993.1488 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1432-1033.1995.tb20594.x http://dx.doi.org/10.1111/j.1432-1033.1995.tb20594.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.6.5.11 http://www.genome.jp/dbget-bin/www_bget?EC:1.6.5.11 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19569 http://www.ebi.ac.uk/ena/data/view/L19569 EMBL L25055 http://www.ebi.ac.uk/ena/data/view/L25055 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X68301 http://www.ebi.ac.uk/ena/data/view/X68301 ENZYME 1.6.5.11 http://enzyme.expasy.org/EC/1.6.5.11 EchoBASE EB1723 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1723 EcoGene EG11774 http://www.ecogene.org/geneInfo.php?eg_id=EG11774 EnsemblBacteria AAC75344 http://www.ensemblgenomes.org/id/AAC75344 EnsemblBacteria AAC75344 http://www.ensemblgenomes.org/id/AAC75344 EnsemblBacteria BAA16113 http://www.ensemblgenomes.org/id/BAA16113 EnsemblBacteria BAA16113 http://www.ensemblgenomes.org/id/BAA16113 EnsemblBacteria BAA16113 http://www.ensemblgenomes.org/id/BAA16113 EnsemblBacteria b2284 http://www.ensemblgenomes.org/id/b2284 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0030964 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030964 GO_component GO:0045272 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045272 GO_function GO:0008137 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008137 GO_function GO:0010181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010181 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0048038 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048038 GO_function GO:0051287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051287 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0009060 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009060 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GeneID 946753 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946753 HOGENOM HOG000251534 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000251534&db=HOGENOM6 InParanoid P31979 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31979 IntAct P31979 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31979* IntEnz 1.6.5.11 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.6.5.11 InterPro IPR001949 http://www.ebi.ac.uk/interpro/entry/IPR001949 InterPro IPR011537 http://www.ebi.ac.uk/interpro/entry/IPR011537 InterPro IPR011538 http://www.ebi.ac.uk/interpro/entry/IPR011538 InterPro IPR019554 http://www.ebi.ac.uk/interpro/entry/IPR019554 InterPro IPR019575 http://www.ebi.ac.uk/interpro/entry/IPR019575 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2279 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2279 KEGG_Gene eco:b2284 http://www.genome.jp/dbget-bin/www_bget?eco:b2284 KEGG_Orthology KO:K00335 http://www.genome.jp/dbget-bin/www_bget?KO:K00335 KEGG_Pathway ko00190 http://www.genome.jp/kegg-bin/show_pathway?ko00190 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Reaction rn:R02166 http://www.genome.jp/dbget-bin/www_bget?rn:R02166 OMA NTFCAHA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NTFCAHA PROSITE PS00644 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00644 PROSITE PS00645 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00645 PSORT swissprot:NUOF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NUOF_ECOLI PSORT-B swissprot:NUOF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NUOF_ECOLI PSORT2 swissprot:NUOF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NUOF_ECOLI Pfam PF01512 http://pfam.xfam.org/family/PF01512 Pfam PF10531 http://pfam.xfam.org/family/PF10531 Pfam PF10589 http://pfam.xfam.org/family/PF10589 Phobius swissprot:NUOF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NUOF_ECOLI PhylomeDB P31979 http://phylomedb.org/?seqid=P31979 ProteinModelPortal P31979 http://www.proteinmodelportal.org/query/uniprot/P31979 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7607227 http://www.ncbi.nlm.nih.gov/pubmed/7607227 PubMed 7690854 http://www.ncbi.nlm.nih.gov/pubmed/7690854 PubMed 8157582 http://www.ncbi.nlm.nih.gov/pubmed/8157582 PubMed 8366049 http://www.ncbi.nlm.nih.gov/pubmed/8366049 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416787 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416787 RefSeq WP_000789500 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000789500 SMART SM00928 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00928 SMR P31979 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31979 STRING 511145.b2284 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2284&targetmode=cogs STRING COG1894 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1894&targetmode=cogs TCDB 3.D.1.1 http://www.tcdb.org/search/result.php?tc=3.D.1.1 TIGRFAMs TIGR01959 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01959 UniProtKB NUOF_ECOLI http://www.uniprot.org/uniprot/NUOF_ECOLI UniProtKB-AC P31979 http://www.uniprot.org/uniprot/P31979 charge swissprot:NUOF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NUOF_ECOLI eggNOG COG1894 http://eggnogapi.embl.de/nog_data/html/tree/COG1894 eggNOG ENOG4107QIZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QIZ epestfind swissprot:NUOF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NUOF_ECOLI garnier swissprot:NUOF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NUOF_ECOLI helixturnhelix swissprot:NUOF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NUOF_ECOLI hmoment swissprot:NUOF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NUOF_ECOLI iep swissprot:NUOF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NUOF_ECOLI inforesidue swissprot:NUOF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NUOF_ECOLI octanol swissprot:NUOF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NUOF_ECOLI pepcoil swissprot:NUOF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NUOF_ECOLI pepdigest swissprot:NUOF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NUOF_ECOLI pepinfo swissprot:NUOF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NUOF_ECOLI pepnet swissprot:NUOF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NUOF_ECOLI pepstats swissprot:NUOF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NUOF_ECOLI pepwheel swissprot:NUOF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NUOF_ECOLI pepwindow swissprot:NUOF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NUOF_ECOLI sigcleave swissprot:NUOF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NUOF_ECOLI ## Database ID URL or Descriptions # AltName HTPX_ECOLI Heat shock protein HtpX # BioGrid 4260355 7 # COFACTOR HTPX_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000305|PubMed 16076848}; Note=Binds 1 zinc ion per subunit. {ECO 0000305|PubMed 16076848}; # DISRUPTION PHENOTYPE No visible phenotype, however one of HtpX or FtsH is essential for cell viability. {ECO:0000269|PubMed 1826904}. # EcoGene EG10462 htpX # FUNCTION HTPX_ECOLI Membrane-localized protease able to endoproteolytically degrade overproduced SecY but not YccA, another membrane protein. It seems to cleave SecY at specific cytoplasmic sites. Does not require ATP. Its natural substrate has not been identified. Probably plays a role in the quality control of integral membrane proteins. {ECO 0000269|PubMed 16076848}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IDA:EcoCyc. # GO_function GO:0004222 metalloendopeptidase activity; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_process GO:0006508 proteolysis; IDA:EcoCyc. # GO_process GO:0009266 response to temperature stimulus; IEP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # HAMAP MF_00188 Pept_M48_protease_HtpX # INDUCTION HTPX_ECOLI By temperature upshift (by the sigma-32 heat shock transcription factor). Also under control of CpxR. {ECO 0000269|PubMed 12081643, ECO 0000269|PubMed 1826904}. # InterPro IPR001915 Peptidase_M48 # InterPro IPR022919 Pept_M48_protease_HtpX # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # Organism HTPX_ECOLI Escherichia coli (strain K12) # PATRIC 32118979 VBIEscCol129921_1907 # PIR A43659 A43659 # PTM HTPX_ECOLI Undergoes self-cleavage. This may not be physiological. # Pfam PF01435 Peptidase_M48 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HTPX_ECOLI Protease HtpX # RefSeq NP_416343 NC_000913.3 # RefSeq WP_000984520 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase M48B family. {ECO 0000305}. # SUBCELLULAR LOCATION HTPX_ECOLI Cell inner membrane {ECO 0000269|PubMed 12081643}; Multi-pass membrane protein {ECO 0000269|PubMed 12081643}. Note=Bioinformatics programs predict 4 transmembrane helices, however PhoA and Bla fusions as well as other experiments only confirm the first 2. {ECO 0000269|PubMed 12081643}. # TCDB 9.B.1.1 the integral membrane caax protease (caax protease) family # eggNOG COG0501 LUCA # eggNOG ENOG4105D0M Bacteria BLAST swissprot:HTPX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HTPX_ECOLI BioCyc ECOL316407:JW1818-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1818-MONOMER BioCyc EcoCyc:EG10462-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10462-MONOMER COG COG0501 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0501 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2443.2002.00554.x http://dx.doi.org/10.1046/j.1365-2443.2002.00554.x DOI 10.1073/pnas.92.25.11921 http://dx.doi.org/10.1073/pnas.92.25.11921 DOI 10.1074/jbc.M506180200 http://dx.doi.org/10.1074/jbc.M506180200 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/jb/mvp071 http://dx.doi.org/10.1093/jb/mvp071 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.24.- http://www.genome.jp/dbget-bin/www_bget?EC:3.4.24.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M58470 http://www.ebi.ac.uk/ena/data/view/M58470 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.4.24.- http://enzyme.expasy.org/EC/3.4.24.- EchoBASE EB0457 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0457 EcoGene EG10462 http://www.ecogene.org/geneInfo.php?eg_id=EG10462 EnsemblBacteria AAC74899 http://www.ensemblgenomes.org/id/AAC74899 EnsemblBacteria AAC74899 http://www.ensemblgenomes.org/id/AAC74899 EnsemblBacteria BAA15637 http://www.ensemblgenomes.org/id/BAA15637 EnsemblBacteria BAA15637 http://www.ensemblgenomes.org/id/BAA15637 EnsemblBacteria BAA15637 http://www.ensemblgenomes.org/id/BAA15637 EnsemblBacteria b1829 http://www.ensemblgenomes.org/id/b1829 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0004222 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004222 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_process GO:0006508 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006508 GO_process GO:0009266 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009266 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 946076 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946076 HAMAP MF_00188 http://hamap.expasy.org/unirule/MF_00188 HOGENOM HOG000227302 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000227302&db=HOGENOM6 InParanoid P23894 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23894 IntEnz 3.4.24 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.24 InterPro IPR001915 http://www.ebi.ac.uk/interpro/entry/IPR001915 InterPro IPR022919 http://www.ebi.ac.uk/interpro/entry/IPR022919 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW1818 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1818 KEGG_Gene eco:b1829 http://www.genome.jp/dbget-bin/www_bget?eco:b1829 KEGG_Orthology KO:K03799 http://www.genome.jp/dbget-bin/www_bget?KO:K03799 OMA AWIASRF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AWIASRF PSORT swissprot:HTPX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HTPX_ECOLI PSORT-B swissprot:HTPX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HTPX_ECOLI PSORT2 swissprot:HTPX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HTPX_ECOLI Pfam PF01435 http://pfam.xfam.org/family/PF01435 Phobius swissprot:HTPX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HTPX_ECOLI PhylomeDB P23894 http://phylomedb.org/?seqid=P23894 ProteinModelPortal P23894 http://www.proteinmodelportal.org/query/uniprot/P23894 PubMed 12081643 http://www.ncbi.nlm.nih.gov/pubmed/12081643 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16076848 http://www.ncbi.nlm.nih.gov/pubmed/16076848 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1826904 http://www.ncbi.nlm.nih.gov/pubmed/1826904 PubMed 19454621 http://www.ncbi.nlm.nih.gov/pubmed/19454621 PubMed 8524875 http://www.ncbi.nlm.nih.gov/pubmed/8524875 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416343 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416343 RefSeq WP_000984520 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000984520 STRING 511145.b1829 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1829&targetmode=cogs STRING COG0501 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0501&targetmode=cogs TCDB 9.B.1.1 http://www.tcdb.org/search/result.php?tc=9.B.1.1 UniProtKB HTPX_ECOLI http://www.uniprot.org/uniprot/HTPX_ECOLI UniProtKB-AC P23894 http://www.uniprot.org/uniprot/P23894 charge swissprot:HTPX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HTPX_ECOLI eggNOG COG0501 http://eggnogapi.embl.de/nog_data/html/tree/COG0501 eggNOG ENOG4105D0M http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D0M epestfind swissprot:HTPX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HTPX_ECOLI garnier swissprot:HTPX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HTPX_ECOLI helixturnhelix swissprot:HTPX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HTPX_ECOLI hmoment swissprot:HTPX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HTPX_ECOLI iep swissprot:HTPX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HTPX_ECOLI inforesidue swissprot:HTPX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HTPX_ECOLI octanol swissprot:HTPX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HTPX_ECOLI pepcoil swissprot:HTPX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HTPX_ECOLI pepdigest swissprot:HTPX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HTPX_ECOLI pepinfo swissprot:HTPX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HTPX_ECOLI pepnet swissprot:HTPX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HTPX_ECOLI pepstats swissprot:HTPX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HTPX_ECOLI pepwheel swissprot:HTPX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HTPX_ECOLI pepwindow swissprot:HTPX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HTPX_ECOLI sigcleave swissprot:HTPX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HTPX_ECOLI ## Database ID URL or Descriptions # EcoGene EG40008 insH6 # FUNCTION INSH6_ECOLI Involved in the transposition of the insertion sequence IS5. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004803 transposase activity; IDA:EcoCyc. # GO_process GO:0006313 transposition, DNA-mediated; IDA:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # InterPro IPR002559 Transposase_11 # InterPro IPR008490 Transposase_InsH_N # Organism INSH6_ECOLI Escherichia coli (strain K12) # PATRIC 32119321 VBIEscCol129921_2070 # Pfam PF01609 DDE_Tnp_1 # Pfam PF05598 DUF772 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSH6_ECOLI Transposase InsH for insertion sequence element IS5H # RefSeq NP_416498 NC_000913.3 # SIMILARITY Belongs to the transposase 11 family. {ECO 0000305}. # eggNOG COG3039 LUCA # eggNOG ENOG4105F2I Bacteria BLAST swissprot:INSH6_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSH6_ECOLI BioCyc EcoCyc:G7074-MONOMER http://biocyc.org/getid?id=EcoCyc:G7074-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4730 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4730 EcoGene EG40008 http://www.ecogene.org/geneInfo.php?eg_id=EG40008 EnsemblBacteria AAC75055 http://www.ensemblgenomes.org/id/AAC75055 EnsemblBacteria AAC75055 http://www.ensemblgenomes.org/id/AAC75055 EnsemblBacteria BAA15811 http://www.ensemblgenomes.org/id/BAA15811 EnsemblBacteria BAA15811 http://www.ensemblgenomes.org/id/BAA15811 EnsemblBacteria BAA15811 http://www.ensemblgenomes.org/id/BAA15811 EnsemblBacteria b1994 http://www.ensemblgenomes.org/id/b1994 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GeneID 946507 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946507 InParanoid P0CE53 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CE53 InterPro IPR002559 http://www.ebi.ac.uk/interpro/entry/IPR002559 InterPro IPR008490 http://www.ebi.ac.uk/interpro/entry/IPR008490 KEGG_Gene ecj:JW1972 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1972 KEGG_Gene eco:b1994 http://www.genome.jp/dbget-bin/www_bget?eco:b1994 PSORT swissprot:INSH6_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSH6_ECOLI PSORT-B swissprot:INSH6_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSH6_ECOLI PSORT2 swissprot:INSH6_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSH6_ECOLI Pfam PF01609 http://pfam.xfam.org/family/PF01609 Pfam PF05598 http://pfam.xfam.org/family/PF05598 Phobius swissprot:INSH6_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSH6_ECOLI ProteinModelPortal P0CE53 http://www.proteinmodelportal.org/query/uniprot/P0CE53 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416498 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416498 STRING 511145.b1994 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1994&targetmode=cogs UniProtKB INSH6_ECOLI http://www.uniprot.org/uniprot/INSH6_ECOLI UniProtKB-AC P0CE53 http://www.uniprot.org/uniprot/P0CE53 charge swissprot:INSH6_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSH6_ECOLI eggNOG COG3039 http://eggnogapi.embl.de/nog_data/html/tree/COG3039 eggNOG ENOG4105F2I http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F2I epestfind swissprot:INSH6_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSH6_ECOLI garnier swissprot:INSH6_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSH6_ECOLI helixturnhelix swissprot:INSH6_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSH6_ECOLI hmoment swissprot:INSH6_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSH6_ECOLI iep swissprot:INSH6_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSH6_ECOLI inforesidue swissprot:INSH6_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSH6_ECOLI octanol swissprot:INSH6_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSH6_ECOLI pepcoil swissprot:INSH6_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSH6_ECOLI pepdigest swissprot:INSH6_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSH6_ECOLI pepinfo swissprot:INSH6_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSH6_ECOLI pepnet swissprot:INSH6_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSH6_ECOLI pepstats swissprot:INSH6_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSH6_ECOLI pepwheel swissprot:INSH6_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSH6_ECOLI pepwindow swissprot:INSH6_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSH6_ECOLI sigcleave swissprot:INSH6_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSH6_ECOLI ## Database ID URL or Descriptions # BioGrid 4259544 15 # CDD cd11567 YciH_like # EcoGene EG11128 yciH # GO_component GO:0070992 translation initiation complex; IDA:EcoCyc. # GO_function GO:0003729 mRNA binding; IBA:GO_Central. # GO_function GO:0003743 translation initiation factor activity; IDA:EcoCyc. # GO_function GO:0043022 ribosome binding; IDA:EcoCyc. # GO_process GO:0001731 formation of translation preinitiation complex; IBA:GO_Central. # GO_process GO:0002188 translation reinitiation; IBA:GO_Central. # GO_process GO:0002192 IRES-dependent translational initiation; IBA:GO_Central. # GO_process GO:0006413 translational initiation; IDA:EcoCyc. # GO_process GO:0006417 regulation of translation; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003729 mRNA binding # GOslim_function GO:0008135 translation factor activity, RNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0022618 ribonucleoprotein complex assembly # Gene3D 3.30.780.10 -; 1. # IntAct P08245 48 # InterPro IPR001950 SUI1 # InterPro IPR005872 SUI1_arc_bac # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko03012 Translation factors # KEGG_Pathway ko03013 RNA transport # Organism YCIH_ECOLI Escherichia coli (strain K12) # PATRIC 32117828 VBIEscCol129921_1334 # PDB 1D1R NMR; -; A=1-108 # PIR E64876 Q3ECPF # PIRSF PIRSF037511 Transl_init_SUI1_pro # PROSITE PS50296 SUI1 # Pfam PF01253 SUI1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCIH_ECOLI Uncharacterized protein YciH # RefSeq NP_415798 NC_000913.3 # RefSeq WP_001295580 NZ_LN832404.1 # SIMILARITY Belongs to the SUI1 family. {ECO 0000305}. # SUPFAM SSF55159 SSF55159 # TIGRFAMs TIGR01158 SUI1_rel # eggNOG COG0023 LUCA # eggNOG ENOG4108ZJT Bacteria BLAST swissprot:YCIH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCIH_ECOLI BioCyc ECOL316407:JW1274-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1274-MONOMER BioCyc EcoCyc:EG11128-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11128-MONOMER COG COG0023 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0023 DIP DIP-11582N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11582N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/27.20.4018 http://dx.doi.org/10.1093/nar/27.20.4018 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J02768 http://www.ebi.ac.uk/ena/data/view/J02768 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1118 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1118 EcoGene EG11128 http://www.ecogene.org/geneInfo.php?eg_id=EG11128 EnsemblBacteria AAC74364 http://www.ensemblgenomes.org/id/AAC74364 EnsemblBacteria AAC74364 http://www.ensemblgenomes.org/id/AAC74364 EnsemblBacteria BAA14836 http://www.ensemblgenomes.org/id/BAA14836 EnsemblBacteria BAA14836 http://www.ensemblgenomes.org/id/BAA14836 EnsemblBacteria BAA14836 http://www.ensemblgenomes.org/id/BAA14836 EnsemblBacteria b1282 http://www.ensemblgenomes.org/id/b1282 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0070992 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070992 GO_function GO:0003729 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003729 GO_function GO:0003743 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003743 GO_function GO:0043022 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043022 GO_process GO:0001731 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001731 GO_process GO:0002188 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002188 GO_process GO:0002192 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002192 GO_process GO:0006413 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006413 GO_process GO:0006417 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006417 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003729 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003729 GOslim_function GO:0008135 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008135 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0022618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022618 Gene3D 3.30.780.10 http://www.cathdb.info/version/latest/superfamily/3.30.780.10 GeneID 947058 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947058 HOGENOM HOG000279814 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000279814&db=HOGENOM6 InParanoid P08245 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P08245 IntAct P08245 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P08245* InterPro IPR001950 http://www.ebi.ac.uk/interpro/entry/IPR001950 InterPro IPR005872 http://www.ebi.ac.uk/interpro/entry/IPR005872 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko03012 http://www.genome.jp/dbget-bin/www_bget?ko03012 KEGG_Gene ecj:JW1274 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1274 KEGG_Gene eco:b1282 http://www.genome.jp/dbget-bin/www_bget?eco:b1282 KEGG_Orthology KO:K03113 http://www.genome.jp/dbget-bin/www_bget?KO:K03113 KEGG_Pathway ko03013 http://www.genome.jp/kegg-bin/show_pathway?ko03013 MINT MINT-1276753 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1276753 OMA EIQGDNR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EIQGDNR PDB 1D1R http://www.ebi.ac.uk/pdbe-srv/view/entry/1D1R PDBsum 1D1R http://www.ebi.ac.uk/pdbsum/1D1R PROSITE PS50296 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50296 PSORT swissprot:YCIH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCIH_ECOLI PSORT-B swissprot:YCIH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCIH_ECOLI PSORT2 swissprot:YCIH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCIH_ECOLI Pfam PF01253 http://pfam.xfam.org/family/PF01253 Phobius swissprot:YCIH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCIH_ECOLI PhylomeDB P08245 http://phylomedb.org/?seqid=P08245 ProteinModelPortal P08245 http://www.proteinmodelportal.org/query/uniprot/P08245 PubMed 10497266 http://www.ncbi.nlm.nih.gov/pubmed/10497266 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2956254 http://www.ncbi.nlm.nih.gov/pubmed/2956254 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415798 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415798 RefSeq WP_001295580 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295580 SMR P08245 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P08245 STRING 511145.b1282 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1282&targetmode=cogs STRING COG0023 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0023&targetmode=cogs SUPFAM SSF55159 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55159 TIGRFAMs TIGR01158 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01158 UniProtKB YCIH_ECOLI http://www.uniprot.org/uniprot/YCIH_ECOLI UniProtKB-AC P08245 http://www.uniprot.org/uniprot/P08245 charge swissprot:YCIH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCIH_ECOLI eggNOG COG0023 http://eggnogapi.embl.de/nog_data/html/tree/COG0023 eggNOG ENOG4108ZJT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZJT epestfind swissprot:YCIH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCIH_ECOLI garnier swissprot:YCIH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCIH_ECOLI helixturnhelix swissprot:YCIH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCIH_ECOLI hmoment swissprot:YCIH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCIH_ECOLI iep swissprot:YCIH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCIH_ECOLI inforesidue swissprot:YCIH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCIH_ECOLI octanol swissprot:YCIH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCIH_ECOLI pepcoil swissprot:YCIH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCIH_ECOLI pepdigest swissprot:YCIH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCIH_ECOLI pepinfo swissprot:YCIH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCIH_ECOLI pepnet swissprot:YCIH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCIH_ECOLI pepstats swissprot:YCIH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCIH_ECOLI pepwheel swissprot:YCIH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCIH_ECOLI pepwindow swissprot:YCIH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCIH_ECOLI sigcleave swissprot:YCIH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCIH_ECOLI ## Database ID URL or Descriptions # BioGrid 4261184 7 # COFACTOR RL31_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 22196016}; Note=Binds 1 zinc ion per subunit. Only 1 ligand appears to be Cys, the other are thought to be His and either backbone amides or solvent (PubMed 22196016). {ECO 0000269|PubMed 22196016}; # EcoGene EG10889 rpmE # FUNCTION RL31_ECOLI Binds the 23S rRNA. {ECO 0000250}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0022625 cytosolic large ribosomal subunit; IDA:EcoCyc. # GO_function GO:0003735 structural constituent of ribosome; IEA:InterPro. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_function GO:0019843 rRNA binding; IEA:UniProtKB-KW. # GO_process GO:0006412 translation; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_function GO:0019843 rRNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006412 translation # HAMAP MF_00501 Ribosomal_L31_1 # IntAct P0A7M9 14 # InterPro IPR002150 Ribosomal_L31 # InterPro IPR027491 Ribosomal_L31_A # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=6971.1; Method=MALDI; Range=1-62; Evidence={ECO:0000269|PubMed 10094780}; # MASS SPECTROMETRY Mass=7871.0; Method=MALDI; Range=1-70; Evidence={ECO:0000269|PubMed 10094780}; # Organism RL31_ECOLI Escherichia coli (strain K12) # PATRIC 32123389 VBIEscCol129921_4055 # PDB 2J28 EM; 8.00 A; Z=1-70 # PDB 2RDO EM; 9.10 A; Z=1-70 # PDB 3BBX EM; 10.00 A; Z=1-70 # PDB 3J9Y EM; 3.90 A; 6=1-70 # PDB 3J9Z EM; 3.60 A; LZ=1-70 # PDB 3JA1 EM; 3.60 A; L2=1-70 # PDB 4V4H X-ray; 3.46 A; BZ/DZ=1-70 # PDB 4V4Q X-ray; 3.46 A; BZ/DZ=1-70 # PDB 4V5B X-ray; 3.74 A; AZ/CZ=1-70 # PDB 4V65 EM; 9.00 A; BS=1-70 # PDB 4V66 EM; 9.00 A; BS=1-70 # PDB 4V6K EM; 8.25 A; Ab=1-70 # PDB 4V6L EM; 13.20 A; Bb=1-70 # PDB 4V6N EM; 12.10 A; A2=1-70 # PDB 4V6O EM; 14.70 A; B2=1-70 # PDB 4V6P EM; 13.50 A; B2=1-70 # PDB 4V6Q EM; 11.50 A; B2=1-70 # PDB 4V6R EM; 11.50 A; B2=1-70 # PDB 4V6S EM; 13.10 A; A2=1-70 # PDB 4V6V EM; 9.80 A; B4=1-70 # PDB 5AFI EM; 2.90 A; 6=1-70 # PDB 5AKA EM; 5.70 A; Z=1-70 # PDB 5IQR EM; 3.00 A; a=1-70 # PDB 5KCS EM; 3.90 A; 14=1-70 # PDB 5KPS EM; 3.90 A; 1=1-70 # PDB 5KPV EM; 4.10 A; Z=1-70 # PDB 5KPW EM; 3.90 A; Z=1-70 # PDB 5KPX EM; 3.90 A; Z=1-70 # PDB 5L3P EM; 3.70 A; 4=1-70 # PIR S40879 R5EC31 # PRINTS PR01249 RIBOSOMALL31 # PROSITE PS01143 RIBOSOMAL_L31 # PTM RL31_ECOLI Proteolytically cleaved by protease VII to yield a peptide lacking residues 63-70. It is not clear if this is due to protein degradation or is a bona fide processing event in the strain used in PubMed 339950 and PubMed 10556732. In strains B, D10, MRE-600 and Q13 the only protein seen in PubMed 10556732 was full length; the last 7 amino acids were sequenced only for strain MRE-600. # Pfam PF01197 Ribosomal_L31 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RL31_ECOLI 50S ribosomal protein L31 # RefSeq NP_418371 NC_000913.3 # RefSeq WP_000710769 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein L31P family. Type A subfamily. {ECO 0000305}. # SUBUNIT RL31_ECOLI Part of the 50S ribosomal subunit. # TIGRFAMs TIGR00105 L31 # eggNOG COG0254 LUCA # eggNOG ENOG4105VFB Bacteria BLAST swissprot:RL31_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RL31_ECOLI BioCyc ECOL316407:JW3907-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3907-MONOMER BioCyc EcoCyc:EG10889-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10889-MONOMER BioCyc MetaCyc:EG10889-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10889-MONOMER COG COG0254 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0254 DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1016/j.jinorgbio.2011.11.022 http://dx.doi.org/10.1016/j.jinorgbio.2011.11.022 DOI 10.1021/bi00596a020 http://dx.doi.org/10.1021/bi00596a020 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1111/j.1574-6968.1998.tb13343.x http://dx.doi.org/10.1111/j.1574-6968.1998.tb13343.x DOI 10.1111/j.1574-6968.1999.tb08816.x http://dx.doi.org/10.1111/j.1574-6968.1999.tb08816.x DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X78541 http://www.ebi.ac.uk/ena/data/view/X78541 EchoBASE EB0882 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0882 EcoGene EG10889 http://www.ecogene.org/geneInfo.php?eg_id=EG10889 EnsemblBacteria AAC76918 http://www.ensemblgenomes.org/id/AAC76918 EnsemblBacteria AAC76918 http://www.ensemblgenomes.org/id/AAC76918 EnsemblBacteria BAE77374 http://www.ensemblgenomes.org/id/BAE77374 EnsemblBacteria BAE77374 http://www.ensemblgenomes.org/id/BAE77374 EnsemblBacteria BAE77374 http://www.ensemblgenomes.org/id/BAE77374 EnsemblBacteria b3936 http://www.ensemblgenomes.org/id/b3936 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0022625 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022625 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GeneID 948425 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948425 HAMAP MF_00501 http://hamap.expasy.org/unirule/MF_00501 HOGENOM HOG000284895 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000284895&db=HOGENOM6 InParanoid P0A7M9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7M9 IntAct P0A7M9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7M9* InterPro IPR002150 http://www.ebi.ac.uk/interpro/entry/IPR002150 InterPro IPR027491 http://www.ebi.ac.uk/interpro/entry/IPR027491 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW3907 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3907 KEGG_Gene eco:b3936 http://www.genome.jp/dbget-bin/www_bget?eco:b3936 KEGG_Orthology KO:K02909 http://www.genome.jp/dbget-bin/www_bget?KO:K02909 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 OMA YTGQQKA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YTGQQKA PDB 2J28 http://www.ebi.ac.uk/pdbe-srv/view/entry/2J28 PDB 2RDO http://www.ebi.ac.uk/pdbe-srv/view/entry/2RDO PDB 3BBX http://www.ebi.ac.uk/pdbe-srv/view/entry/3BBX PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5AKA http://www.ebi.ac.uk/pdbe-srv/view/entry/5AKA PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 2J28 http://www.ebi.ac.uk/pdbsum/2J28 PDBsum 2RDO http://www.ebi.ac.uk/pdbsum/2RDO PDBsum 3BBX http://www.ebi.ac.uk/pdbsum/3BBX PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5AKA http://www.ebi.ac.uk/pdbsum/5AKA PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PRINTS PR01249 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01249 PROSITE PS01143 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01143 PSORT swissprot:RL31_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RL31_ECOLI PSORT-B swissprot:RL31_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RL31_ECOLI PSORT2 swissprot:RL31_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RL31_ECOLI Pfam PF01197 http://pfam.xfam.org/family/PF01197 Phobius swissprot:RL31_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RL31_ECOLI PhylomeDB P0A7M9 http://phylomedb.org/?seqid=P0A7M9 ProteinModelPortal P0A7M9 http://www.proteinmodelportal.org/query/uniprot/P0A7M9 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 10556732 http://www.ncbi.nlm.nih.gov/pubmed/10556732 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 22196016 http://www.ncbi.nlm.nih.gov/pubmed/22196016 PubMed 339950 http://www.ncbi.nlm.nih.gov/pubmed/339950 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9868784 http://www.ncbi.nlm.nih.gov/pubmed/9868784 RefSeq NP_418371 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418371 RefSeq WP_000710769 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000710769 SMR P0A7M9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7M9 STRING 511145.b3936 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3936&targetmode=cogs STRING COG0254 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0254&targetmode=cogs TIGRFAMs TIGR00105 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00105 UniProtKB RL31_ECOLI http://www.uniprot.org/uniprot/RL31_ECOLI UniProtKB-AC P0A7M9 http://www.uniprot.org/uniprot/P0A7M9 charge swissprot:RL31_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RL31_ECOLI eggNOG COG0254 http://eggnogapi.embl.de/nog_data/html/tree/COG0254 eggNOG ENOG4105VFB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VFB epestfind swissprot:RL31_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RL31_ECOLI garnier swissprot:RL31_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RL31_ECOLI helixturnhelix swissprot:RL31_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RL31_ECOLI hmoment swissprot:RL31_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RL31_ECOLI iep swissprot:RL31_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RL31_ECOLI inforesidue swissprot:RL31_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RL31_ECOLI octanol swissprot:RL31_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RL31_ECOLI pepcoil swissprot:RL31_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RL31_ECOLI pepdigest swissprot:RL31_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RL31_ECOLI pepinfo swissprot:RL31_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RL31_ECOLI pepnet swissprot:RL31_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RL31_ECOLI pepstats swissprot:RL31_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RL31_ECOLI pepwheel swissprot:RL31_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RL31_ECOLI pepwindow swissprot:RL31_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RL31_ECOLI sigcleave swissprot:RL31_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RL31_ECOLI ## Database ID URL or Descriptions # AltName SGBE_ECOLI Phosphoribulose isomerase # BioGrid 4262553 9 # CATALYTIC ACTIVITY SGBE_ECOLI L-ribulose 5-phosphate = D-xylulose 5- phosphate. # COFACTOR SGBE_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000305}; Note=Binds 1 zinc ion per subunit. {ECO 0000305}; # EcoGene EG12287 sgbE # FUNCTION SGBE_ECOLI Catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate. May be involved in the utilization of 2,3- diketo-L-gulonate. {ECO 0000269|PubMed 10913097, ECO 0000269|PubMed 11741871}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0008270 zinc ion binding; IEA:InterPro. # GO_function GO:0008742 L-ribulose-phosphate 4-epimerase activity; IDA:EcoCyc. # GO_function GO:0016832 aldehyde-lyase activity; IBA:GO_Central. # GO_process GO:0019323 pentose catabolic process; IMP:EcoCyc. # GO_process GO:0019324 L-lyxose metabolic process; IMP:EcoCyc. # GO_process GO:0019572 L-arabinose catabolic process; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.225.10 -; 1. # IntAct P37680 13 # InterPro IPR001303 Aldolase_II/adducin_N # InterPro IPR004661 AraD # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00040 Pentose and glucuronate interconversions # Organism SGBE_ECOLI Escherichia coli (strain K12) # PATRIC 32122642 VBIEscCol129921_3698 # PIR S47804 S47804 # Pfam PF00596 Aldolase_II # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SGBE_ECOLI L-ribulose-5-phosphate 4-epimerase SgbE # RefSeq NP_418040 NC_000913.3 # RefSeq WP_000893142 NZ_LN832404.1 # SIMILARITY Belongs to the aldolase class II family. AraD/FucA subfamily. {ECO 0000305}. # SMART SM01007 Aldolase_II # SUPFAM SSF53639 SSF53639 # TIGRFAMs TIGR00760 araD # eggNOG COG0235 LUCA # eggNOG ENOG4107R0P Bacteria BLAST swissprot:SGBE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SGBE_ECOLI BioCyc ECOL316407:JW3555-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3555-MONOMER BioCyc EcoCyc:EG12287-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12287-MONOMER BioCyc MetaCyc:EG12287-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12287-MONOMER COG COG0235 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0235 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.16.4625-4627.2000 http://dx.doi.org/10.1128/JB.182.16.4625-4627.2000 DOI 10.1128/JB.184.1.302-306.2002 http://dx.doi.org/10.1128/JB.184.1.302-306.2002 EC_number EC:5.1.3.4 http://www.genome.jp/dbget-bin/www_bget?EC:5.1.3.4 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 5.1.3.4 http://enzyme.expasy.org/EC/5.1.3.4 EchoBASE EB2195 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2195 EcoGene EG12287 http://www.ecogene.org/geneInfo.php?eg_id=EG12287 EnsemblBacteria AAC76607 http://www.ensemblgenomes.org/id/AAC76607 EnsemblBacteria AAC76607 http://www.ensemblgenomes.org/id/AAC76607 EnsemblBacteria BAE77710 http://www.ensemblgenomes.org/id/BAE77710 EnsemblBacteria BAE77710 http://www.ensemblgenomes.org/id/BAE77710 EnsemblBacteria BAE77710 http://www.ensemblgenomes.org/id/BAE77710 EnsemblBacteria b3583 http://www.ensemblgenomes.org/id/b3583 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0008742 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008742 GO_function GO:0016832 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016832 GO_process GO:0019323 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019323 GO_process GO:0019324 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019324 GO_process GO:0019572 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019572 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.225.10 http://www.cathdb.info/version/latest/superfamily/3.40.225.10 GeneID 948099 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948099 HOGENOM HOG000218183 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218183&db=HOGENOM6 InParanoid P37680 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37680 IntAct P37680 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37680* IntEnz 5.1.3.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.1.3.4 InterPro IPR001303 http://www.ebi.ac.uk/interpro/entry/IPR001303 InterPro IPR004661 http://www.ebi.ac.uk/interpro/entry/IPR004661 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3555 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3555 KEGG_Gene eco:b3583 http://www.genome.jp/dbget-bin/www_bget?eco:b3583 KEGG_Orthology KO:K03080 http://www.genome.jp/dbget-bin/www_bget?KO:K03080 KEGG_Pathway ko00040 http://www.genome.jp/kegg-bin/show_pathway?ko00040 KEGG_Reaction rn:R05850 http://www.genome.jp/dbget-bin/www_bget?rn:R05850 OMA GVEYEHM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GVEYEHM PSORT swissprot:SGBE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SGBE_ECOLI PSORT-B swissprot:SGBE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SGBE_ECOLI PSORT2 swissprot:SGBE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SGBE_ECOLI Pfam PF00596 http://pfam.xfam.org/family/PF00596 Phobius swissprot:SGBE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SGBE_ECOLI PhylomeDB P37680 http://phylomedb.org/?seqid=P37680 ProteinModelPortal P37680 http://www.proteinmodelportal.org/query/uniprot/P37680 PubMed 10913097 http://www.ncbi.nlm.nih.gov/pubmed/10913097 PubMed 11741871 http://www.ncbi.nlm.nih.gov/pubmed/11741871 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418040 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418040 RefSeq WP_000893142 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000893142 SMART SM01007 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01007 SMR P37680 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37680 STRING 511145.b3583 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3583&targetmode=cogs STRING COG0235 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0235&targetmode=cogs SUPFAM SSF53639 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53639 TIGRFAMs TIGR00760 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00760 UniProtKB SGBE_ECOLI http://www.uniprot.org/uniprot/SGBE_ECOLI UniProtKB-AC P37680 http://www.uniprot.org/uniprot/P37680 charge swissprot:SGBE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SGBE_ECOLI eggNOG COG0235 http://eggnogapi.embl.de/nog_data/html/tree/COG0235 eggNOG ENOG4107R0P http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107R0P epestfind swissprot:SGBE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SGBE_ECOLI garnier swissprot:SGBE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SGBE_ECOLI helixturnhelix swissprot:SGBE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SGBE_ECOLI hmoment swissprot:SGBE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SGBE_ECOLI iep swissprot:SGBE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SGBE_ECOLI inforesidue swissprot:SGBE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SGBE_ECOLI octanol swissprot:SGBE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SGBE_ECOLI pepcoil swissprot:SGBE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SGBE_ECOLI pepdigest swissprot:SGBE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SGBE_ECOLI pepinfo swissprot:SGBE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SGBE_ECOLI pepnet swissprot:SGBE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SGBE_ECOLI pepstats swissprot:SGBE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SGBE_ECOLI pepwheel swissprot:SGBE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SGBE_ECOLI pepwindow swissprot:SGBE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SGBE_ECOLI sigcleave swissprot:SGBE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SGBE_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES AEEP_ECOLI Kinetic parameters KM=0.13 mM for L-Ala-D-Glu (at pH 8.5) {ECO 0000269|PubMed 11747447}; KM=0.19 mM for L-Ala-D-Asp (at pH 8.5) {ECO 0000269|PubMed 11747447}; KM=0.69 mM for L-Ala-D-Met (at pH 8.5) {ECO 0000269|PubMed 11747447}; KM=1.8 mM for L-Ala-D-Gln (at pH 8.5) {ECO 0000269|PubMed 11747447}; # BioGrid 4260152 370 # CATALYTIC ACTIVITY L-alanyl-D-glutamate = L-alanyl-L-glutamate. {ECO:0000269|PubMed 11747447}. # COFACTOR AEEP_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250}; Note=Binds 1 Mg(2+) ion per subunit. {ECO 0000250}; # EcoGene EG13228 ycjG # FUNCTION AEEP_ECOLI Catalyzes the epimerization of L-Ala-D-Glu to L-Ala-L- Glu and has a role in the recycling of the murein peptide, of which L-Ala-D-Glu is a component. Is also able to catalyze the reverse reaction and the epimerization of all the L-Ala-X dipeptides, except L-Ala-L-Arg, L-Ala-L-Lys and L-Ala-L-Pro. Is also active with L-Gly-L-Glu, L-Phe-L-Glu, and L-Ser-L-Glu, but not with L-Glu-L-Glu, L-Lys-L-Glu, L-Pro-L-Glu, L-Lys-L-Ala, or D- Ala-D-Ala. {ECO 0000269|PubMed 11747447, ECO 0000269|PubMed 18535144}. # GO_function GO:0016855 racemase and epimerase activity, acting on amino acids and derivatives; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0009063 cellular amino acid catabolic process; IEA:InterPro. # GO_process GO:0009254 peptidoglycan turnover; IEA:UniProtKB-UniPathway. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 3.20.20.120 -; 1. # Gene3D 3.30.390.10 -; 1. # InterPro IPR001354 MR/MLE/MAL # InterPro IPR013341 Mandelate_racemase_N_dom # InterPro IPR013342 Mandelate_racemase_C # InterPro IPR018110 Mandel_Rmase/mucon_lact_enz_CS # InterPro IPR029017 Enolase_N-like # InterPro IPR029065 Enolase_C-like # Organism AEEP_ECOLI Escherichia coli (strain K12) # PANTHER PTHR13794 PTHR13794 # PATHWAY AEEP_ECOLI Cell wall biogenesis; peptidoglycan recycling. # PATRIC 32117924 VBIEscCol129921_1382 # PDB 1JPD X-ray; 2.60 A; X=1-321 # PIR H64881 H64881 # PROSITE PS00908 MR_MLE_1 # PROSITE PS00909 MR_MLE_2 # Pfam PF02746 MR_MLE_N # Pfam PF13378 MR_MLE_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AEEP_ECOLI L-Ala-D/L-Glu epimerase # RefSeq NP_415841 NC_000913.3 # RefSeq WP_001261211 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=U33213; Type=Erroneous termination; Positions=275; Note=Translated as Cys.; Evidence={ECO:0000305}; Sequence=U33213; Type=Frameshift; Positions=285; Evidence={ECO 0000305}; # SIMILARITY Belongs to the mandelate racemase/muconate lactonizing enzyme family. {ECO 0000305}. # SMART SM00922 MR_MLE # SUBUNIT Monomer. {ECO:0000269|PubMed 11747448}. # SUPFAM SSF51604 SSF51604 # SUPFAM SSF54826 SSF54826 # eggNOG COG4948 LUCA # eggNOG ENOG4107S8C Bacteria BLAST swissprot:AEEP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AEEP_ECOLI BioCyc ECOL316407:JW1318-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1318-MONOMER BioCyc EcoCyc:G6661-MONOMER http://biocyc.org/getid?id=EcoCyc:G6661-MONOMER BioCyc MetaCyc:G6661-MONOMER http://biocyc.org/getid?id=MetaCyc:G6661-MONOMER DOI 10.1021/bi011640x http://dx.doi.org/10.1021/bi011640x DOI 10.1021/bi011641p http://dx.doi.org/10.1021/bi011641p DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.270.48.28635 http://dx.doi.org/10.1074/jbc.270.48.28635 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/MMBR.00027-07 http://dx.doi.org/10.1128/MMBR.00027-07 EC_number EC:5.1.1.20 {ECO:0000269|PubMed:11747447} http://www.genome.jp/dbget-bin/www_bget?EC:5.1.1.20 {ECO:0000269|PubMed:11747447} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U33213 http://www.ebi.ac.uk/ena/data/view/U33213 ENZYME 5.1.1.20 {ECO:0000269|PubMed:11747447} http://enzyme.expasy.org/EC/5.1.1.20 {ECO:0000269|PubMed:11747447} EchoBASE EB3018 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3018 EcoGene EG13228 http://www.ecogene.org/geneInfo.php?eg_id=EG13228 EnsemblBacteria AAC74407 http://www.ensemblgenomes.org/id/AAC74407 EnsemblBacteria AAC74407 http://www.ensemblgenomes.org/id/AAC74407 EnsemblBacteria BAA14907 http://www.ensemblgenomes.org/id/BAA14907 EnsemblBacteria BAA14907 http://www.ensemblgenomes.org/id/BAA14907 EnsemblBacteria BAA14907 http://www.ensemblgenomes.org/id/BAA14907 EnsemblBacteria b1325 http://www.ensemblgenomes.org/id/b1325 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016855 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016855 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0009063 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009063 GO_process GO:0009254 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009254 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 3.20.20.120 http://www.cathdb.info/version/latest/superfamily/3.20.20.120 Gene3D 3.30.390.10 http://www.cathdb.info/version/latest/superfamily/3.30.390.10 GeneID 946013 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946013 HOGENOM HOG000185901 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000185901&db=HOGENOM6 InParanoid P51981 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P51981 IntAct P51981 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P51981* IntEnz 5.1.1.20 {ECO:0000269|PubMed:11747447} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.1.1.20 {ECO:0000269|PubMed:11747447} InterPro IPR001354 http://www.ebi.ac.uk/interpro/entry/IPR001354 InterPro IPR013341 http://www.ebi.ac.uk/interpro/entry/IPR013341 InterPro IPR013342 http://www.ebi.ac.uk/interpro/entry/IPR013342 InterPro IPR018110 http://www.ebi.ac.uk/interpro/entry/IPR018110 InterPro IPR029017 http://www.ebi.ac.uk/interpro/entry/IPR029017 InterPro IPR029065 http://www.ebi.ac.uk/interpro/entry/IPR029065 KEGG_Gene ecj:JW1318 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1318 KEGG_Gene eco:b1325 http://www.genome.jp/dbget-bin/www_bget?eco:b1325 OMA RVYEEAW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RVYEEAW PANTHER PTHR13794 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13794 PDB 1JPD http://www.ebi.ac.uk/pdbe-srv/view/entry/1JPD PDBsum 1JPD http://www.ebi.ac.uk/pdbsum/1JPD PROSITE PS00908 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00908 PROSITE PS00909 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00909 PSORT swissprot:AEEP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AEEP_ECOLI PSORT-B swissprot:AEEP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AEEP_ECOLI PSORT2 swissprot:AEEP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AEEP_ECOLI Pfam PF02746 http://pfam.xfam.org/family/PF02746 Pfam PF13378 http://pfam.xfam.org/family/PF13378 Phobius swissprot:AEEP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AEEP_ECOLI PhylomeDB P51981 http://phylomedb.org/?seqid=P51981 ProteinModelPortal P51981 http://www.proteinmodelportal.org/query/uniprot/P51981 PubMed 11747447 http://www.ncbi.nlm.nih.gov/pubmed/11747447 PubMed 11747448 http://www.ncbi.nlm.nih.gov/pubmed/11747448 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18535144 http://www.ncbi.nlm.nih.gov/pubmed/18535144 PubMed 7499381 http://www.ncbi.nlm.nih.gov/pubmed/7499381 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415841 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415841 RefSeq WP_001261211 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001261211 SMART SM00922 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00922 SMR P51981 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P51981 STRING 511145.b1325 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1325&targetmode=cogs SUPFAM SSF51604 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51604 SUPFAM SSF54826 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54826 UniProtKB AEEP_ECOLI http://www.uniprot.org/uniprot/AEEP_ECOLI UniProtKB-AC P51981 http://www.uniprot.org/uniprot/P51981 charge swissprot:AEEP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AEEP_ECOLI eggNOG COG4948 http://eggnogapi.embl.de/nog_data/html/tree/COG4948 eggNOG ENOG4107S8C http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107S8C epestfind swissprot:AEEP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AEEP_ECOLI garnier swissprot:AEEP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AEEP_ECOLI helixturnhelix swissprot:AEEP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AEEP_ECOLI hmoment swissprot:AEEP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AEEP_ECOLI iep swissprot:AEEP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AEEP_ECOLI inforesidue swissprot:AEEP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AEEP_ECOLI octanol swissprot:AEEP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AEEP_ECOLI pepcoil swissprot:AEEP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AEEP_ECOLI pepdigest swissprot:AEEP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AEEP_ECOLI pepinfo swissprot:AEEP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AEEP_ECOLI pepnet swissprot:AEEP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AEEP_ECOLI pepstats swissprot:AEEP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AEEP_ECOLI pepwheel swissprot:AEEP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AEEP_ECOLI pepwindow swissprot:AEEP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AEEP_ECOLI sigcleave swissprot:AEEP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AEEP_ECOLI ## Database ID URL or Descriptions # EcoGene EG40004 insD2 # FUNCTION INSD2_ECOLI Involved in the transposition of the insertion sequence IS2. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006310 DNA recombination; IEA:UniProtKB-KW. # GO_process GO:0015074 DNA integration; IEA:InterPro. # GO_process GO:0032196 transposition; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 3.30.420.10 -; 1. # InterPro IPR001584 Integrase_cat-core # InterPro IPR012337 RNaseH-like_dom # InterPro IPR025948 HTH-like_dom # Organism INSD2_ECOLI Escherichia coli (strain K12) # PIR A64764 C65092 # PROSITE PS50994 INTEGRASE # Pfam PF00665 rve # Pfam PF13276 HTH_21 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSD2_ECOLI Transposase InsD for insertion element IS2D # RefSeq NP_061399 NC_002483.1 # RefSeq NP_414895 NC_000913.3 # RefSeq NP_415920 NC_000913.3 # RefSeq NP_416500 NC_000913.3 # RefSeq NP_417337 NC_000913.3 # RefSeq NP_417517 NC_000913.3 # RefSeq NP_418693 NC_000913.3 # RefSeq WP_000376502 NZ_LN832404.1 # SIMILARITY Contains 1 integrase catalytic domain. {ECO:0000255|PROSITE-ProRule PRU00457}. # SUPFAM SSF53098 SSF53098 # eggNOG ENOG4108MVM Bacteria # eggNOG ENOG410Z4Y8 LUCA BLAST swissprot:INSD2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSD2_ECOLI DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4724 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4724 EcoGene EG40004 http://www.ecogene.org/geneInfo.php?eg_id=EG40004 EnsemblBacteria AAC74484 http://www.ensemblgenomes.org/id/AAC74484 EnsemblBacteria AAC74484 http://www.ensemblgenomes.org/id/AAC74484 EnsemblBacteria BAA15010 http://www.ensemblgenomes.org/id/BAA15010 EnsemblBacteria BAA15010 http://www.ensemblgenomes.org/id/BAA15010 EnsemblBacteria BAA15010 http://www.ensemblgenomes.org/id/BAA15010 EnsemblBacteria b1402 http://www.ensemblgenomes.org/id/b1402 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0015074 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015074 GO_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 3.30.420.10 http://www.cathdb.info/version/latest/superfamily/3.30.420.10 GeneID 1263540 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263540 GeneID 945203 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945203 GeneID 945952 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945952 GeneID 946403 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946403 GeneID 947346 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947346 GeneID 947517 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947517 GeneID 948779 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948779 InParanoid P0CF54 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CF54 InterPro IPR001584 http://www.ebi.ac.uk/interpro/entry/IPR001584 InterPro IPR012337 http://www.ebi.ac.uk/interpro/entry/IPR012337 InterPro IPR025948 http://www.ebi.ac.uk/interpro/entry/IPR025948 KEGG_Gene ecj:JW1397 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1397 KEGG_Gene eco:b0361 http://www.genome.jp/dbget-bin/www_bget?eco:b0361 KEGG_Gene eco:b1402 http://www.genome.jp/dbget-bin/www_bget?eco:b1402 KEGG_Gene eco:b1996 http://www.genome.jp/dbget-bin/www_bget?eco:b1996 KEGG_Gene eco:b2860 http://www.genome.jp/dbget-bin/www_bget?eco:b2860 KEGG_Gene eco:b3045 http://www.genome.jp/dbget-bin/www_bget?eco:b3045 KEGG_Gene eco:b4273 http://www.genome.jp/dbget-bin/www_bget?eco:b4273 PROSITE PS50994 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50994 PSORT swissprot:INSD2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSD2_ECOLI PSORT-B swissprot:INSD2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSD2_ECOLI PSORT2 swissprot:INSD2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSD2_ECOLI Pfam PF00665 http://pfam.xfam.org/family/PF00665 Pfam PF13276 http://pfam.xfam.org/family/PF13276 Phobius swissprot:INSD2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSD2_ECOLI PhylomeDB P0CF54 http://phylomedb.org/?seqid=P0CF54 ProteinModelPortal P0CF54 http://www.proteinmodelportal.org/query/uniprot/P0CF54 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_061399 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061399 RefSeq NP_414895 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414895 RefSeq NP_415920 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415920 RefSeq NP_416500 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416500 RefSeq NP_417337 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417337 RefSeq NP_417517 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417517 RefSeq NP_418693 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418693 RefSeq WP_000376502 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000376502 SMR P0CF54 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0CF54 STRING 511145.b4273 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4273&targetmode=cogs SUPFAM SSF53098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098 UniProtKB INSD2_ECOLI http://www.uniprot.org/uniprot/INSD2_ECOLI UniProtKB-AC P0CF54 http://www.uniprot.org/uniprot/P0CF54 charge swissprot:INSD2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSD2_ECOLI eggNOG ENOG4108MVM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MVM eggNOG ENOG410Z4Y8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Z4Y8 epestfind swissprot:INSD2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSD2_ECOLI garnier swissprot:INSD2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSD2_ECOLI helixturnhelix swissprot:INSD2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSD2_ECOLI hmoment swissprot:INSD2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSD2_ECOLI iep swissprot:INSD2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSD2_ECOLI inforesidue swissprot:INSD2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSD2_ECOLI octanol swissprot:INSD2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSD2_ECOLI pepcoil swissprot:INSD2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSD2_ECOLI pepdigest swissprot:INSD2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSD2_ECOLI pepinfo swissprot:INSD2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSD2_ECOLI pepnet swissprot:INSD2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSD2_ECOLI pepstats swissprot:INSD2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSD2_ECOLI pepwheel swissprot:INSD2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSD2_ECOLI pepwindow swissprot:INSD2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSD2_ECOLI sigcleave swissprot:INSD2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSD2_ECOLI ## Database ID URL or Descriptions # AltName Cytochrome c maturation protein E {ECO:0000255|HAMAP-Rule MF_01959} # AltName Heme chaperone CcmE {ECO:0000255|HAMAP-Rule MF_01959} # BioGrid 4260483 111 # EcoGene EG12055 ccmE # FUNCTION CCME_ECOLI Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_component GO:0031237 intrinsic component of periplasmic side of plasma membrane; IDA:EcoCyc. # GO_function GO:0020037 heme binding; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0015886 heme transport; IDA:EcoCyc. # GO_process GO:0018063 cytochrome c-heme linkage; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0006810 transport # HAMAP MF_01959 CcmE # INTERACTION CCME_ECOLI P0ABM1 ccmC; NbExp=6; IntAct=EBI-1128007, EBI-2123469; # IntAct P69490 6 # InterPro IPR004329 CcmE # Organism CCME_ECOLI Escherichia coli (strain K12) # PATRIC 32119753 VBIEscCol129921_2286 # PDB 1SR3 NMR; -; A=30-159 # PIR C64989 C64989 # Pfam PF03100 CcmE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Cytochrome c-type biogenesis protein CcmE {ECO:0000255|HAMAP-Rule MF_01959} # RefSeq NP_416701 NC_000913.3 # RefSeq WP_001026418 NZ_LN832404.1 # SIMILARITY Belongs to the CcmE/CycJ family. {ECO:0000255|HAMAP- Rule MF_01959}. # SUBCELLULAR LOCATION CCME_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01959}; Single-pass type II membrane protein {ECO 0000255|HAMAP-Rule MF_01959}; Periplasmic side {ECO 0000255|HAMAP-Rule MF_01959}. Note=Stabilized by CcmD in the membrane. # SUBUNIT CCME_ECOLI Forms a ternary complex with CcmC and CcmD. Interacts with CcmF. Shuttles between CcmC and CcmF for heme delivery. {ECO 0000269|PubMed 11384983, ECO 0000269|PubMed 11744735, ECO 0000269|PubMed 15513913}. # SUPFAM SSF82093 SSF82093 # eggNOG COG2332 LUCA # eggNOG ENOG4108ZKK Bacteria BLAST swissprot:CCME_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CCME_ECOLI BioCyc ECOL316407:JW2185-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2185-MONOMER BioCyc EcoCyc:CCME-MONOMER http://biocyc.org/getid?id=EcoCyc:CCME-MONOMER BioCyc MetaCyc:CCME-MONOMER http://biocyc.org/getid?id=MetaCyc:CCME-MONOMER COG COG2332 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2332 DIP DIP-9255N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9255N DOI 10.1016/S0969-2126(02)00885-7 http://dx.doi.org/10.1016/S0969-2126(02)00885-7 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M103058200 http://dx.doi.org/10.1074/jbc.M103058200 DOI 10.1074/jbc.M110979200 http://dx.doi.org/10.1074/jbc.M110979200 DOI 10.1074/jbc.M410912200 http://dx.doi.org/10.1074/jbc.M410912200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1126/science.281.5380.1197 http://dx.doi.org/10.1126/science.281.5380.1197 DOI 10.1128/JB.185.1.175-183.2003 http://dx.doi.org/10.1128/JB.185.1.175-183.2003 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00008 http://www.ebi.ac.uk/ena/data/view/U00008 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1986 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1986 EcoGene EG12055 http://www.ecogene.org/geneInfo.php?eg_id=EG12055 EnsemblBacteria AAC75257 http://www.ensemblgenomes.org/id/AAC75257 EnsemblBacteria AAC75257 http://www.ensemblgenomes.org/id/AAC75257 EnsemblBacteria BAE76660 http://www.ensemblgenomes.org/id/BAE76660 EnsemblBacteria BAE76660 http://www.ensemblgenomes.org/id/BAE76660 EnsemblBacteria BAE76660 http://www.ensemblgenomes.org/id/BAE76660 EnsemblBacteria b2197 http://www.ensemblgenomes.org/id/b2197 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0031237 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031237 GO_function GO:0020037 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0020037 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0015886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015886 GO_process GO:0018063 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018063 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 946697 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946697 HAMAP MF_01959 http://hamap.expasy.org/unirule/MF_01959 HOGENOM HOG000009661 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009661&db=HOGENOM6 InParanoid P69490 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P69490 IntAct P69490 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69490* InterPro IPR004329 http://www.ebi.ac.uk/interpro/entry/IPR004329 KEGG_Gene ecj:JW2185 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2185 KEGG_Gene eco:b2197 http://www.genome.jp/dbget-bin/www_bget?eco:b2197 KEGG_Orthology KO:K02197 http://www.genome.jp/dbget-bin/www_bget?KO:K02197 MINT MINT-1503318 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1503318 OMA HVEFAVH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HVEFAVH PDB 1SR3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1SR3 PDBsum 1SR3 http://www.ebi.ac.uk/pdbsum/1SR3 PSORT swissprot:CCME_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CCME_ECOLI PSORT-B swissprot:CCME_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CCME_ECOLI PSORT2 swissprot:CCME_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CCME_ECOLI Pfam PF03100 http://pfam.xfam.org/family/PF03100 Phobius swissprot:CCME_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CCME_ECOLI PhylomeDB P69490 http://phylomedb.org/?seqid=P69490 ProteinModelPortal P69490 http://www.proteinmodelportal.org/query/uniprot/P69490 PubMed 11384983 http://www.ncbi.nlm.nih.gov/pubmed/11384983 PubMed 11744735 http://www.ncbi.nlm.nih.gov/pubmed/11744735 PubMed 12429096 http://www.ncbi.nlm.nih.gov/pubmed/12429096 PubMed 12486054 http://www.ncbi.nlm.nih.gov/pubmed/12486054 PubMed 15513913 http://www.ncbi.nlm.nih.gov/pubmed/15513913 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7635817 http://www.ncbi.nlm.nih.gov/pubmed/7635817 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9712585 http://www.ncbi.nlm.nih.gov/pubmed/9712585 RefSeq NP_416701 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416701 RefSeq WP_001026418 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001026418 SMR P69490 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69490 STRING 511145.b2197 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2197&targetmode=cogs STRING COG2332 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2332&targetmode=cogs SUPFAM SSF82093 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF82093 UniProtKB CCME_ECOLI http://www.uniprot.org/uniprot/CCME_ECOLI UniProtKB-AC P69490 http://www.uniprot.org/uniprot/P69490 charge swissprot:CCME_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CCME_ECOLI eggNOG COG2332 http://eggnogapi.embl.de/nog_data/html/tree/COG2332 eggNOG ENOG4108ZKK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZKK epestfind swissprot:CCME_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CCME_ECOLI garnier swissprot:CCME_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CCME_ECOLI helixturnhelix swissprot:CCME_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CCME_ECOLI hmoment swissprot:CCME_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CCME_ECOLI iep swissprot:CCME_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CCME_ECOLI inforesidue swissprot:CCME_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CCME_ECOLI octanol swissprot:CCME_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CCME_ECOLI pepcoil swissprot:CCME_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CCME_ECOLI pepdigest swissprot:CCME_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CCME_ECOLI pepinfo swissprot:CCME_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CCME_ECOLI pepnet swissprot:CCME_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CCME_ECOLI pepstats swissprot:CCME_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CCME_ECOLI pepwheel swissprot:CCME_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CCME_ECOLI pepwindow swissprot:CCME_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CCME_ECOLI sigcleave swissprot:CCME_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CCME_ECOLI ## Database ID URL or Descriptions # AltName Galactonate H(+) symporter # BioGrid 4262773 112 # CDD cd06174 MFS # DISRUPTION PHENOTYPE Cells lacking this gene fail to grow on L- galactonate as sole carbon source. {ECO:0000269|PubMed 17088549}. # EcoGene EG12588 lgoT # FUNCTION LGOT_ECOLI Probably responsible for the transport of L-galactonate from the periplasm across the inner membrane. Is essential for growth on L-galactonate as the sole carbon source. {ECO 0000269|PubMed 17088549}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IBA:GO_Central. # GO_function GO:0022857 transmembrane transporter activity; IBA:GO_Central. # GO_process GO:0008643 carbohydrate transport; IEA:UniProtKB-KW. # GO_process GO:0042873 aldonate transport; IMP:EcoCyc. # GO_process GO:0055085 transmembrane transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # INDUCTION Highly up-regulated during growth on L-galactonate. {ECO:0000269|PubMed 17088549}. # InterPro IPR000849 Sugar_P_transporter # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # Organism LGOT_ECOLI Escherichia coli (strain K12) # PATRIC 32124318 VBIEscCol129921_4502 # PIR F65250 F65250 # PIR S56583 S56583 # PIRSF PIRSF002808 Hexose_phosphate_transp # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LGOT_ECOLI Probable L-galactonate transporter # RefSeq NP_418776 NC_000913.3 # RefSeq WP_000410113 NZ_LN832404.1 # SIMILARITY Belongs to the major facilitator superfamily. Phthalate permease family. {ECO 0000305}. # SUBCELLULAR LOCATION LGOT_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255}. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.14.33 the major facilitator superfamily (mfs) # eggNOG ENOG4108I5G Bacteria # eggNOG ENOG410XRW2 LUCA BLAST swissprot:LGOT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LGOT_ECOLI BioCyc ECOL316407:JW4319-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4319-MONOMER BioCyc EcoCyc:YJIZ-MONOMER http://biocyc.org/getid?id=EcoCyc:YJIZ-MONOMER BioCyc MetaCyc:YJIZ-MONOMER http://biocyc.org/getid?id=MetaCyc:YJIZ-MONOMER DIP DIP-12656N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12656N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0603364103 http://dx.doi.org/10.1073/pnas.0603364103 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2473 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2473 EcoGene EG12588 http://www.ecogene.org/geneInfo.php?eg_id=EG12588 EnsemblBacteria AAC77312 http://www.ensemblgenomes.org/id/AAC77312 EnsemblBacteria AAC77312 http://www.ensemblgenomes.org/id/AAC77312 EnsemblBacteria BAE78346 http://www.ensemblgenomes.org/id/BAE78346 EnsemblBacteria BAE78346 http://www.ensemblgenomes.org/id/BAE78346 EnsemblBacteria BAE78346 http://www.ensemblgenomes.org/id/BAE78346 EnsemblBacteria b4356 http://www.ensemblgenomes.org/id/b4356 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GO_process GO:0008643 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008643 GO_process GO:0042873 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042873 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 948879 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948879 HOGENOM HOG000113641 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000113641&db=HOGENOM6 InParanoid P39398 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39398 IntAct P39398 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39398* InterPro IPR000849 http://www.ebi.ac.uk/interpro/entry/IPR000849 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Gene ecj:JW4319 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4319 KEGG_Gene eco:b4356 http://www.genome.jp/dbget-bin/www_bget?eco:b4356 MINT MINT-1309486 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1309486 OMA RVAFLTI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RVAFLTI PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:LGOT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LGOT_ECOLI PSORT-B swissprot:LGOT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LGOT_ECOLI PSORT2 swissprot:LGOT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LGOT_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:LGOT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LGOT_ECOLI PhylomeDB P39398 http://phylomedb.org/?seqid=P39398 ProteinModelPortal P39398 http://www.proteinmodelportal.org/query/uniprot/P39398 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17088549 http://www.ncbi.nlm.nih.gov/pubmed/17088549 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418776 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418776 RefSeq WP_000410113 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000410113 STRING 511145.b4356 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4356&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.14.33 http://www.tcdb.org/search/result.php?tc=2.A.1.14.33 UniProtKB LGOT_ECOLI http://www.uniprot.org/uniprot/LGOT_ECOLI UniProtKB-AC P39398 http://www.uniprot.org/uniprot/P39398 charge swissprot:LGOT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LGOT_ECOLI eggNOG ENOG4108I5G http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108I5G eggNOG ENOG410XRW2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRW2 epestfind swissprot:LGOT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LGOT_ECOLI garnier swissprot:LGOT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LGOT_ECOLI helixturnhelix swissprot:LGOT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LGOT_ECOLI hmoment swissprot:LGOT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LGOT_ECOLI iep swissprot:LGOT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LGOT_ECOLI inforesidue swissprot:LGOT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LGOT_ECOLI octanol swissprot:LGOT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LGOT_ECOLI pepcoil swissprot:LGOT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LGOT_ECOLI pepdigest swissprot:LGOT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LGOT_ECOLI pepinfo swissprot:LGOT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LGOT_ECOLI pepnet swissprot:LGOT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LGOT_ECOLI pepstats swissprot:LGOT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LGOT_ECOLI pepwheel swissprot:LGOT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LGOT_ECOLI pepwindow swissprot:LGOT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LGOT_ECOLI sigcleave swissprot:LGOT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LGOT_ECOLI ## Database ID URL or Descriptions # BioGrid 4263536 349 # CDD cd04458 CSP_CDS # EcoGene EG12204 cspC # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0001072 transcription antitermination factor activity, RNA binding; IDA:EcoliWiki. # GO_function GO:0003697 single-stranded DNA binding; IDA:EcoliWiki. # GO_function GO:0003723 RNA binding; IDA:EcoliWiki. # GO_function GO:0051087 chaperone binding; IDA:CACAO. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0060567 negative regulation of DNA-templated transcription, termination; IDA:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0003723 RNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # IntAct P0A9Y6 73 # InterPro IPR002059 CSP_DNA-bd # InterPro IPR011129 Cold_shock_prot # InterPro IPR012156 Cold_shock_CspA # InterPro IPR012340 NA-bd_OB-fold # InterPro IPR019844 Cold-shock_CS # KEGG_Brite ko03000 Transcription factors # MASS SPECTROMETRY Mass=7273; Method=Electrospray; Range=2-69; Evidence={ECO:0000269|PubMed 12071744}; # Organism CSPC_ECOLI Escherichia coli (strain K12) # PATRIC 32118965 VBIEscCol129921_1900 # PIR S43618 S43618 # PIRSF PIRSF002599 Cold_shock_A # PRINTS PR00050 COLDSHOCK # PROSITE PS00352 COLD_SHOCK # Pfam PF00313 CSD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CSPC_ECOLI Cold shock-like protein CspC # RefSeq NP_416337 NC_000913.3 # RefSeq WP_001062678 NZ_LN832404.1 # SIMILARITY Contains 1 CSD (cold-shock) domain. {ECO 0000305}. # SMART SM00357 CSP # SUBCELLULAR LOCATION CSPC_ECOLI Cytoplasm {ECO 0000250}. # SUPFAM SSF50249 SSF50249 # eggNOG COG1278 LUCA BLAST swissprot:CSPC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CSPC_ECOLI BioCyc ECOL316407:JW1812-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1812-MONOMER BioCyc EcoCyc:EG12204-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12204-MONOMER COG COG1278 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1278 DIP DIP-36183N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36183N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1021/ja025966k http://dx.doi.org/10.1021/ja025966k DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1111/j.1365-2958.1994.tb00361.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb00361.x DOI 10.1111/j.1365-2958.1994.tb00424.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb00424.x DOI 10.1111/j.1574-6968.1998.tb13343.x http://dx.doi.org/10.1111/j.1574-6968.1998.tb13343.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D28496 http://www.ebi.ac.uk/ena/data/view/D28496 EMBL L28430 http://www.ebi.ac.uk/ena/data/view/L28430 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2120 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2120 EcoGene EG12204 http://www.ecogene.org/geneInfo.php?eg_id=EG12204 EnsemblBacteria AAC74893 http://www.ensemblgenomes.org/id/AAC74893 EnsemblBacteria AAC74893 http://www.ensemblgenomes.org/id/AAC74893 EnsemblBacteria BAA15634 http://www.ensemblgenomes.org/id/BAA15634 EnsemblBacteria BAA15634 http://www.ensemblgenomes.org/id/BAA15634 EnsemblBacteria BAA15634 http://www.ensemblgenomes.org/id/BAA15634 EnsemblBacteria b1823 http://www.ensemblgenomes.org/id/b1823 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0001072 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001072 GO_function GO:0003697 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003697 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0051087 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051087 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0060567 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060567 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 8911702 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8911702 GeneID 946339 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946339 HOGENOM HOG000070674 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000070674&db=HOGENOM6 InParanoid P0A9Y6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9Y6 IntAct P0A9Y6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9Y6* InterPro IPR002059 http://www.ebi.ac.uk/interpro/entry/IPR002059 InterPro IPR011129 http://www.ebi.ac.uk/interpro/entry/IPR011129 InterPro IPR012156 http://www.ebi.ac.uk/interpro/entry/IPR012156 InterPro IPR012340 http://www.ebi.ac.uk/interpro/entry/IPR012340 InterPro IPR019844 http://www.ebi.ac.uk/interpro/entry/IPR019844 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW1812 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1812 KEGG_Gene eco:b1823 http://www.genome.jp/dbget-bin/www_bget?eco:b1823 KEGG_Orthology KO:K03704 http://www.genome.jp/dbget-bin/www_bget?KO:K03704 MINT MINT-1218847 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1218847 OMA FEIQDGH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FEIQDGH PRINTS PR00050 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00050 PROSITE PS00352 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00352 PSORT swissprot:CSPC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CSPC_ECOLI PSORT-B swissprot:CSPC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CSPC_ECOLI PSORT2 swissprot:CSPC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CSPC_ECOLI Pfam PF00313 http://pfam.xfam.org/family/PF00313 Phobius swissprot:CSPC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CSPC_ECOLI PhylomeDB P0A9Y6 http://phylomedb.org/?seqid=P0A9Y6 ProteinModelPortal P0A9Y6 http://www.proteinmodelportal.org/query/uniprot/P0A9Y6 PubMed 12071744 http://www.ncbi.nlm.nih.gov/pubmed/12071744 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7984109 http://www.ncbi.nlm.nih.gov/pubmed/7984109 PubMed 8022261 http://www.ncbi.nlm.nih.gov/pubmed/8022261 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9868784 http://www.ncbi.nlm.nih.gov/pubmed/9868784 RefSeq NP_416337 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416337 RefSeq WP_001062678 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001062678 SMART SM00357 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00357 SMR P0A9Y6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9Y6 STRING 511145.b1823 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1823&targetmode=cogs STRING COG1278 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1278&targetmode=cogs SUPFAM SSF50249 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50249 SWISS-2DPAGE P0A9Y6 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A9Y6 UniProtKB CSPC_ECOLI http://www.uniprot.org/uniprot/CSPC_ECOLI UniProtKB-AC P0A9Y6 http://www.uniprot.org/uniprot/P0A9Y6 charge swissprot:CSPC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CSPC_ECOLI eggNOG COG1278 http://eggnogapi.embl.de/nog_data/html/tree/COG1278 epestfind swissprot:CSPC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CSPC_ECOLI garnier swissprot:CSPC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CSPC_ECOLI helixturnhelix swissprot:CSPC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CSPC_ECOLI hmoment swissprot:CSPC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CSPC_ECOLI iep swissprot:CSPC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CSPC_ECOLI inforesidue swissprot:CSPC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CSPC_ECOLI octanol swissprot:CSPC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CSPC_ECOLI pepcoil swissprot:CSPC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CSPC_ECOLI pepdigest swissprot:CSPC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CSPC_ECOLI pepinfo swissprot:CSPC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CSPC_ECOLI pepnet swissprot:CSPC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CSPC_ECOLI pepstats swissprot:CSPC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CSPC_ECOLI pepwheel swissprot:CSPC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CSPC_ECOLI pepwindow swissprot:CSPC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CSPC_ECOLI sigcleave swissprot:CSPC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CSPC_ECOLI ## Database ID URL or Descriptions # BioGrid 4262673 239 # EcoGene EG11940 yjcE # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function YJCE_ECOLI GO 0015385 sodium proton antiporter activity; IBA GO_Central. # GO_function YJCE_ECOLI GO 0015386 potassium proton antiporter activity; IBA GO_Central. # GO_process GO:0051453 regulation of intracellular pH; IBA:GO_Central. # GO_process GO:0071805 potassium ion transmembrane transport; IBA:GO_Central. # GO_process GO:0098719 sodium ion import across plasma membrane; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0042592 homeostatic process # GOslim_process GO:0055085 transmembrane transport # InterPro IPR004705 Cation/H_exchanger_CPA1_bac # InterPro IPR006153 Cation/H_exchanger # InterPro IPR018422 Cation/H_exchanger_CPA1 # Organism YJCE_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10110 PTHR10110 # PATRIC 32123677 VBIEscCol129921_4187 # PIR H65214 H65214 # Pfam PF00999 Na_H_Exchanger # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJCE_ECOLI Uncharacterized Na(+)/H(+) exchanger YjcE # RefSeq NP_418489 NC_000913.3 # RefSeq WP_000402210 NZ_LN832404.1 # SIMILARITY Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. {ECO 0000305}. # SUBCELLULAR LOCATION YJCE_ECOLI Cell inner membrane {ECO 0000305}; Multi- pass membrane protein {ECO 0000305}. # TCDB 2.A.36.3:the monovalent cation proton antiporter-1 (cpa1) family # TIGRFAMs TIGR00831 a_cpa1 # eggNOG COG0025 LUCA # eggNOG ENOG4105EEQ Bacteria BLAST swissprot:YJCE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJCE_ECOLI BioCyc ECOL316407:JW4026-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4026-MONOMER BioCyc EcoCyc:YJCE-MONOMER http://biocyc.org/getid?id=EcoCyc:YJCE-MONOMER COG COG0025 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0025 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1884 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1884 EcoGene EG11940 http://www.ecogene.org/geneInfo.php?eg_id=EG11940 EnsemblBacteria AAC77035 http://www.ensemblgenomes.org/id/AAC77035 EnsemblBacteria AAC77035 http://www.ensemblgenomes.org/id/AAC77035 EnsemblBacteria BAE78067 http://www.ensemblgenomes.org/id/BAE78067 EnsemblBacteria BAE78067 http://www.ensemblgenomes.org/id/BAE78067 EnsemblBacteria BAE78067 http://www.ensemblgenomes.org/id/BAE78067 EnsemblBacteria b4065 http://www.ensemblgenomes.org/id/b4065 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015385 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015385 GO_function GO:0015386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015386 GO_process GO:0051453 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051453 GO_process GO:0071805 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805 GO_process GO:0098719 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098719 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 948577 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948577 HOGENOM HOG000263347 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000263347&db=HOGENOM6 InParanoid P32703 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32703 InterPro IPR004705 http://www.ebi.ac.uk/interpro/entry/IPR004705 InterPro IPR006153 http://www.ebi.ac.uk/interpro/entry/IPR006153 InterPro IPR018422 http://www.ebi.ac.uk/interpro/entry/IPR018422 KEGG_Gene ecj:JW4026 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4026 KEGG_Gene eco:b4065 http://www.genome.jp/dbget-bin/www_bget?eco:b4065 KEGG_Orthology KO:K03316 http://www.genome.jp/dbget-bin/www_bget?KO:K03316 OMA HRQHLVG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HRQHLVG PANTHER PTHR10110 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10110 PSORT swissprot:YJCE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJCE_ECOLI PSORT-B swissprot:YJCE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJCE_ECOLI PSORT2 swissprot:YJCE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJCE_ECOLI Pfam PF00999 http://pfam.xfam.org/family/PF00999 Phobius swissprot:YJCE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJCE_ECOLI PhylomeDB P32703 http://phylomedb.org/?seqid=P32703 ProteinModelPortal P32703 http://www.proteinmodelportal.org/query/uniprot/P32703 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418489 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418489 RefSeq WP_000402210 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000402210 STRING 511145.b4065 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4065&targetmode=cogs STRING COG0025 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0025&targetmode=cogs TCDB 2.A.36.3 http://www.tcdb.org/search/result.php?tc=2.A.36.3 TIGRFAMs TIGR00831 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00831 UniProtKB YJCE_ECOLI http://www.uniprot.org/uniprot/YJCE_ECOLI UniProtKB-AC P32703 http://www.uniprot.org/uniprot/P32703 charge swissprot:YJCE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJCE_ECOLI eggNOG COG0025 http://eggnogapi.embl.de/nog_data/html/tree/COG0025 eggNOG ENOG4105EEQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EEQ epestfind swissprot:YJCE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJCE_ECOLI garnier swissprot:YJCE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJCE_ECOLI helixturnhelix swissprot:YJCE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJCE_ECOLI hmoment swissprot:YJCE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJCE_ECOLI iep swissprot:YJCE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJCE_ECOLI inforesidue swissprot:YJCE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJCE_ECOLI octanol swissprot:YJCE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJCE_ECOLI pepcoil swissprot:YJCE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJCE_ECOLI pepdigest swissprot:YJCE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJCE_ECOLI pepinfo swissprot:YJCE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJCE_ECOLI pepnet swissprot:YJCE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJCE_ECOLI pepstats swissprot:YJCE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJCE_ECOLI pepwheel swissprot:YJCE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJCE_ECOLI pepwindow swissprot:YJCE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJCE_ECOLI sigcleave swissprot:YJCE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJCE_ECOLI ## Database ID URL or Descriptions # BioGrid 4263409 27 # EcoGene EG11970 yhdN # IntAct P36677 4 # InterPro IPR018961 DnaJ_homolog_subfam-C_membr-28 # Organism YHDN_ECOLI Escherichia coli (strain K12) # PATRIC 32122018 VBIEscCol129921_3386 # PIR I67893 I67893 # Pfam PF09350 DUF1992 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHDN_ECOLI Uncharacterized protein YhdN # RefSeq NP_417752 NC_000913.3 # RefSeq WP_000266486 NZ_LN832404.1 # eggNOG ENOG4105VTS Bacteria # eggNOG ENOG41122AH LUCA BLAST swissprot:YHDN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHDN_ECOLI BioCyc ECOL316407:JW3255-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3255-MONOMER BioCyc EcoCyc:EG11970-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11970-MONOMER DOI 10.1016/0378-1119(94)90847-8 http://dx.doi.org/10.1016/0378-1119(94)90847-8 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L29458 http://www.ebi.ac.uk/ena/data/view/L29458 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB1913 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1913 EcoGene EG11970 http://www.ecogene.org/geneInfo.php?eg_id=EG11970 EnsemblBacteria AAC76318 http://www.ensemblgenomes.org/id/AAC76318 EnsemblBacteria AAC76318 http://www.ensemblgenomes.org/id/AAC76318 EnsemblBacteria BAE77998 http://www.ensemblgenomes.org/id/BAE77998 EnsemblBacteria BAE77998 http://www.ensemblgenomes.org/id/BAE77998 EnsemblBacteria BAE77998 http://www.ensemblgenomes.org/id/BAE77998 EnsemblBacteria b3293 http://www.ensemblgenomes.org/id/b3293 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947785 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947785 HOGENOM HOG000261565 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261565&db=HOGENOM6 InParanoid P36677 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P36677 IntAct P36677 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P36677* InterPro IPR018961 http://www.ebi.ac.uk/interpro/entry/IPR018961 KEGG_Gene ecj:JW3255 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3255 KEGG_Gene eco:b3293 http://www.genome.jp/dbget-bin/www_bget?eco:b3293 OMA KLRQAGM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KLRQAGM PSORT swissprot:YHDN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHDN_ECOLI PSORT-B swissprot:YHDN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHDN_ECOLI PSORT2 swissprot:YHDN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHDN_ECOLI Pfam PF09350 http://pfam.xfam.org/family/PF09350 Phobius swissprot:YHDN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHDN_ECOLI PhylomeDB P36677 http://phylomedb.org/?seqid=P36677 ProteinModelPortal P36677 http://www.proteinmodelportal.org/query/uniprot/P36677 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8063098 http://www.ncbi.nlm.nih.gov/pubmed/8063098 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417752 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417752 RefSeq WP_000266486 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000266486 SMR P36677 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P36677 STRING 511145.b3293 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3293&targetmode=cogs UniProtKB YHDN_ECOLI http://www.uniprot.org/uniprot/YHDN_ECOLI UniProtKB-AC P36677 http://www.uniprot.org/uniprot/P36677 charge swissprot:YHDN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHDN_ECOLI eggNOG ENOG4105VTS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VTS eggNOG ENOG41122AH http://eggnogapi.embl.de/nog_data/html/tree/ENOG41122AH epestfind swissprot:YHDN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHDN_ECOLI garnier swissprot:YHDN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHDN_ECOLI helixturnhelix swissprot:YHDN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHDN_ECOLI hmoment swissprot:YHDN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHDN_ECOLI iep swissprot:YHDN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHDN_ECOLI inforesidue swissprot:YHDN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHDN_ECOLI octanol swissprot:YHDN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHDN_ECOLI pepcoil swissprot:YHDN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHDN_ECOLI pepdigest swissprot:YHDN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHDN_ECOLI pepinfo swissprot:YHDN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHDN_ECOLI pepnet swissprot:YHDN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHDN_ECOLI pepstats swissprot:YHDN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHDN_ECOLI pepwheel swissprot:YHDN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHDN_ECOLI pepwindow swissprot:YHDN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHDN_ECOLI sigcleave swissprot:YHDN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHDN_ECOLI ## Database ID URL or Descriptions # BioGrid 4262215 12 # EcoGene EG14194 ypfG # IntAct P76559 2 # InterPro IPR009560 DUF1176 # Organism YPFG_ECOLI Escherichia coli (strain K12) # PATRIC 32120315 VBIEscCol129921_2560 # PIR A65022 A65022 # Pfam PF06674 DUF1176 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YPFG_ECOLI Uncharacterized protein YpfG # RefSeq NP_416961 NC_000913.3 # RefSeq WP_001270542 NZ_LN832404.1 # eggNOG ENOG4108PVD Bacteria # eggNOG ENOG410ZMG7 LUCA BLAST swissprot:YPFG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YPFG_ECOLI BioCyc ECOL316407:JW2450-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2450-MONOMER BioCyc EcoCyc:G7295-MONOMER http://biocyc.org/getid?id=EcoCyc:G7295-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3946 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3946 EcoGene EG14194 http://www.ecogene.org/geneInfo.php?eg_id=EG14194 EnsemblBacteria AAC75519 http://www.ensemblgenomes.org/id/AAC75519 EnsemblBacteria AAC75519 http://www.ensemblgenomes.org/id/AAC75519 EnsemblBacteria BAE76721 http://www.ensemblgenomes.org/id/BAE76721 EnsemblBacteria BAE76721 http://www.ensemblgenomes.org/id/BAE76721 EnsemblBacteria BAE76721 http://www.ensemblgenomes.org/id/BAE76721 EnsemblBacteria b2466 http://www.ensemblgenomes.org/id/b2466 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946828 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946828 HOGENOM HOG000123029 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000123029&db=HOGENOM6 IntAct P76559 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76559* InterPro IPR009560 http://www.ebi.ac.uk/interpro/entry/IPR009560 KEGG_Gene ecj:JW2450 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2450 KEGG_Gene eco:b2466 http://www.genome.jp/dbget-bin/www_bget?eco:b2466 OMA ETAWVGK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ETAWVGK PSORT swissprot:YPFG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YPFG_ECOLI PSORT-B swissprot:YPFG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YPFG_ECOLI PSORT2 swissprot:YPFG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YPFG_ECOLI Pfam PF06674 http://pfam.xfam.org/family/PF06674 Phobius swissprot:YPFG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YPFG_ECOLI ProteinModelPortal P76559 http://www.proteinmodelportal.org/query/uniprot/P76559 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416961 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416961 RefSeq WP_001270542 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001270542 SMR P76559 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76559 STRING 511145.b2466 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2466&targetmode=cogs UniProtKB YPFG_ECOLI http://www.uniprot.org/uniprot/YPFG_ECOLI UniProtKB-AC P76559 http://www.uniprot.org/uniprot/P76559 charge swissprot:YPFG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YPFG_ECOLI eggNOG ENOG4108PVD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108PVD eggNOG ENOG410ZMG7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZMG7 epestfind swissprot:YPFG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YPFG_ECOLI garnier swissprot:YPFG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YPFG_ECOLI helixturnhelix swissprot:YPFG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YPFG_ECOLI hmoment swissprot:YPFG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YPFG_ECOLI iep swissprot:YPFG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YPFG_ECOLI inforesidue swissprot:YPFG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YPFG_ECOLI octanol swissprot:YPFG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YPFG_ECOLI pepcoil swissprot:YPFG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YPFG_ECOLI pepdigest swissprot:YPFG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YPFG_ECOLI pepinfo swissprot:YPFG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YPFG_ECOLI pepnet swissprot:YPFG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YPFG_ECOLI pepstats swissprot:YPFG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YPFG_ECOLI pepwheel swissprot:YPFG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YPFG_ECOLI pepwindow swissprot:YPFG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YPFG_ECOLI sigcleave swissprot:YPFG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YPFG_ECOLI ## Database ID URL or Descriptions # BioGrid 4260758 424 # DISRUPTION PHENOTYPE Mutation confers sensitivity to SDS-EDTA and leads to accumulation of phospholipid in the outer leaflet of the outer membrane. {ECO:0000269|PubMed 19383799}. # EcoGene EG12797 mlaB # FUNCTION MLAB_ECOLI Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. {ECO 0000269|PubMed 19383799}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0005548 phospholipid transporter activity; IMP:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IMP:EcoCyc. # GO_process GO:0046677 response to antibiotic; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # Gene3D 3.30.750.24 -; 1. # IntAct P64602 3 # InterPro IPR002645 STAS_dom # Organism MLAB_ECOLI Escherichia coli (strain K12) # PATRIC 32121802 VBIEscCol129921_3285 # PROSITE PS50801 STAS # Pfam PF13466 STAS_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Probable phospholipid ABC transporter-binding protein MlaB {ECO 0000305} # RefSeq NP_417658 NC_000913.3 # RefSeq WP_000004488 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA57992.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Contains 1 STAS domain. {ECO:0000255|PROSITE- ProRule PRU00198}. # SUBCELLULAR LOCATION MLAB_ECOLI Cytoplasm {ECO 0000305|PubMed 19383799}. # SUBUNIT The complex is composed of two ATP-binding proteins (MlaF), two transmembrane proteins (MlaE), two cytoplasmic solute- binding proteins (MlaB) and a periplamic solute-binding protein (MlaD). {ECO:0000305|PubMed 19383799}. # SUPFAM SSF52091 SSF52091 # TCDB 3.A.1.27 the atp-binding cassette (abc) superfamily # eggNOG COG3113 LUCA # eggNOG ENOG4105UE2 Bacteria BLAST swissprot:MLAB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MLAB_ECOLI BioCyc ECOL316407:JW5535-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5535-MONOMER BioCyc EcoCyc:G7658-MONOMER http://biocyc.org/getid?id=EcoCyc:G7658-MONOMER COG COG3113 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3113 DIP DIP-47898N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47898N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0903229106 http://dx.doi.org/10.1073/pnas.0903229106 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2649 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2649 EcoGene EG12797 http://www.ecogene.org/geneInfo.php?eg_id=EG12797 EnsemblBacteria AAC76223 http://www.ensemblgenomes.org/id/AAC76223 EnsemblBacteria AAC76223 http://www.ensemblgenomes.org/id/AAC76223 EnsemblBacteria BAE77235 http://www.ensemblgenomes.org/id/BAE77235 EnsemblBacteria BAE77235 http://www.ensemblgenomes.org/id/BAE77235 EnsemblBacteria BAE77235 http://www.ensemblgenomes.org/id/BAE77235 EnsemblBacteria b3191 http://www.ensemblgenomes.org/id/b3191 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0005548 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005548 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.30.750.24 http://www.cathdb.info/version/latest/superfamily/3.30.750.24 GeneID 947954 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947954 HOGENOM HOG000287451 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000287451&db=HOGENOM6 IntAct P64602 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P64602* InterPro IPR002645 http://www.ebi.ac.uk/interpro/entry/IPR002645 KEGG_Gene ecj:JW5535 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5535 KEGG_Gene eco:b3191 http://www.genome.jp/dbget-bin/www_bget?eco:b3191 KEGG_Orthology KO:K07122 http://www.genome.jp/dbget-bin/www_bget?KO:K07122 OMA NPLWDAR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NPLWDAR PROSITE PS50801 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50801 PSORT swissprot:MLAB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MLAB_ECOLI PSORT-B swissprot:MLAB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MLAB_ECOLI PSORT2 swissprot:MLAB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MLAB_ECOLI Pfam PF13466 http://pfam.xfam.org/family/PF13466 Phobius swissprot:MLAB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MLAB_ECOLI ProteinModelPortal P64602 http://www.proteinmodelportal.org/query/uniprot/P64602 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19383799 http://www.ncbi.nlm.nih.gov/pubmed/19383799 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417658 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417658 RefSeq WP_000004488 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000004488 STRING 511145.b3191 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3191&targetmode=cogs STRING COG3113 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3113&targetmode=cogs SUPFAM SSF52091 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52091 TCDB 3.A.1.27 http://www.tcdb.org/search/result.php?tc=3.A.1.27 UniProtKB MLAB_ECOLI http://www.uniprot.org/uniprot/MLAB_ECOLI UniProtKB-AC P64602 http://www.uniprot.org/uniprot/P64602 charge swissprot:MLAB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MLAB_ECOLI eggNOG COG3113 http://eggnogapi.embl.de/nog_data/html/tree/COG3113 eggNOG ENOG4105UE2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105UE2 epestfind swissprot:MLAB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MLAB_ECOLI garnier swissprot:MLAB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MLAB_ECOLI helixturnhelix swissprot:MLAB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MLAB_ECOLI hmoment swissprot:MLAB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MLAB_ECOLI iep swissprot:MLAB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MLAB_ECOLI inforesidue swissprot:MLAB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MLAB_ECOLI octanol swissprot:MLAB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MLAB_ECOLI pepcoil swissprot:MLAB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MLAB_ECOLI pepdigest swissprot:MLAB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MLAB_ECOLI pepinfo swissprot:MLAB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MLAB_ECOLI pepnet swissprot:MLAB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MLAB_ECOLI pepstats swissprot:MLAB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MLAB_ECOLI pepwheel swissprot:MLAB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MLAB_ECOLI pepwindow swissprot:MLAB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MLAB_ECOLI sigcleave swissprot:MLAB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MLAB_ECOLI ## Database ID URL or Descriptions # BioGrid 4261833 8 # EcoGene EG13673 ybhQ # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR021303 Uncharacterised_YbhQ # Organism YBHQ_ECOLI Escherichia coli (strain K12) # PATRIC 32116783 VBIEscCol129921_0817 # PIR G64815 G64815 # Pfam PF11076 YbhQ # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBHQ_ECOLI Inner membrane protein YbhQ # RefSeq NP_415312 NC_000913.3 # RefSeq WP_000871982 NZ_LN832404.1 # SUBCELLULAR LOCATION YBHQ_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG ENOG4105I9U Bacteria # eggNOG ENOG4111RY6 LUCA BLAST swissprot:YBHQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBHQ_ECOLI BioCyc ECOL316407:JW0774-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0774-MONOMER BioCyc EcoCyc:G6408-MONOMER http://biocyc.org/getid?id=EcoCyc:G6408-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3437 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3437 EcoGene EG13673 http://www.ecogene.org/geneInfo.php?eg_id=EG13673 EnsemblBacteria AAC73878 http://www.ensemblgenomes.org/id/AAC73878 EnsemblBacteria AAC73878 http://www.ensemblgenomes.org/id/AAC73878 EnsemblBacteria BAA35450 http://www.ensemblgenomes.org/id/BAA35450 EnsemblBacteria BAA35450 http://www.ensemblgenomes.org/id/BAA35450 EnsemblBacteria BAA35450 http://www.ensemblgenomes.org/id/BAA35450 EnsemblBacteria b0791 http://www.ensemblgenomes.org/id/b0791 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 945405 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945405 HOGENOM HOG000118090 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118090&db=HOGENOM6 InterPro IPR021303 http://www.ebi.ac.uk/interpro/entry/IPR021303 KEGG_Gene ecj:JW0774 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0774 KEGG_Gene eco:b0791 http://www.genome.jp/dbget-bin/www_bget?eco:b0791 OMA HEARWRE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HEARWRE PSORT swissprot:YBHQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBHQ_ECOLI PSORT-B swissprot:YBHQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBHQ_ECOLI PSORT2 swissprot:YBHQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBHQ_ECOLI Pfam PF11076 http://pfam.xfam.org/family/PF11076 Phobius swissprot:YBHQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBHQ_ECOLI ProteinModelPortal P0AAW5 http://www.proteinmodelportal.org/query/uniprot/P0AAW5 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415312 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415312 RefSeq WP_000871982 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000871982 STRING 511145.b0791 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0791&targetmode=cogs UniProtKB YBHQ_ECOLI http://www.uniprot.org/uniprot/YBHQ_ECOLI UniProtKB-AC P0AAW5 http://www.uniprot.org/uniprot/P0AAW5 charge swissprot:YBHQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBHQ_ECOLI eggNOG ENOG4105I9U http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105I9U eggNOG ENOG4111RY6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111RY6 epestfind swissprot:YBHQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBHQ_ECOLI garnier swissprot:YBHQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBHQ_ECOLI helixturnhelix swissprot:YBHQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBHQ_ECOLI hmoment swissprot:YBHQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBHQ_ECOLI iep swissprot:YBHQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBHQ_ECOLI inforesidue swissprot:YBHQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBHQ_ECOLI octanol swissprot:YBHQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBHQ_ECOLI pepcoil swissprot:YBHQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBHQ_ECOLI pepdigest swissprot:YBHQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBHQ_ECOLI pepinfo swissprot:YBHQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBHQ_ECOLI pepnet swissprot:YBHQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBHQ_ECOLI pepstats swissprot:YBHQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBHQ_ECOLI pepwheel swissprot:YBHQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBHQ_ECOLI pepwindow swissprot:YBHQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBHQ_ECOLI sigcleave swissprot:YBHQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBHQ_ECOLI ## Database ID URL or Descriptions # AltName RSMA_ECOLI 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase # AltName RSMA_ECOLI 16S rRNA dimethyladenosine transferase # AltName RSMA_ECOLI 16S rRNA dimethylase # AltName RSMA_ECOLI High level kasugamycin resistance protein KsgA # AltName RSMA_ECOLI Kasugamycin dimethyltransferase # AltName RSMA_ECOLI S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase # BRENDA 2.1.1.182 2026 # BioGrid 4261012 23 # CATALYTIC ACTIVITY RSMA_ECOLI 4 S-adenosyl-L-methionine + adenine(1518)/adenine(1519) in 16S rRNA = 4 S-adenosyl-L- homocysteine + N(6)-dimethyladenine(1518)/N(6)- dimethyladenine(1519) in 16S rRNA. # DISRUPTION PHENOTYPE RSMA_ECOLI Inactivation leads to kasugamycin resistance. Cells lacking this gene show cold-sensitivity phenotype, altered ribosome profiles, and small subunit rRNA- processing defects. {ECO 0000269|PubMed 18990185, ECO 0000269|PubMed 3905517}. # EcoGene EG10523 rsmA # FUNCTION RSMA_ECOLI Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. Has also a DNA glycosylase/AP lyase activity that removes C mispaired with oxidized T from DNA, and may play a role in protection of DNA against oxidative stress. {ECO 0000269|PubMed 18990185, ECO 0000269|PubMed 19223326, ECO 0000269|PubMed 3905517}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity; IDA:EcoCyc. # GO_function GO:0003690 double-stranded DNA binding; IDA:EcoCyc. # GO_function GO:0003729 mRNA binding; IDA:EcoCyc. # GO_function GO:0019843 rRNA binding; IDA:EcoCyc. # GO_function GO:0052908 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity; IEA:UniProtKB-EC. # GO_process GO:0000028 ribosomal small subunit assembly; IMP:EcoCyc. # GO_process GO:0006364 rRNA processing; IMP:EcoCyc. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GO_process GO:0070475 rRNA base methylation; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0003729 mRNA binding # GOslim_function GO:0008168 methyltransferase activity # GOslim_function GO:0019843 rRNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0022618 ribonucleoprotein complex assembly # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.8.100 -; 1. # Gene3D 3.40.50.150 -; 1. # HAMAP MF_00607 16SrRNA_methyltr_A # IntAct P06992 4 # InterPro IPR001737 KsgA/Erm # InterPro IPR011530 rRNA_adenine_dimethylase # InterPro IPR020596 rRNA_Ade_Mease_Trfase_CS # InterPro IPR020598 rRNA_Ade_methylase_Trfase_N # InterPro IPR023165 rRNA_Ade_diMease-like # InterPro IPR029063 SAM-dependent_MTases # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # MISCELLANEOUS RSMA_ECOLI When overexpressed partially suppresses the slow growth and decreased 70S ribosome phenotype of an rsgA knockout; RsgA may be involved in 30S ribosomal subunit biogenesis. Upon overexpression also restores cold-sensitive growth of a missense mutation in Era. # Organism RSMA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11727 PTHR11727 # PATRIC 32115201 VBIEscCol129921_0052 # PDB 1QYR X-ray; 2.10 A; A/B=17-268 # PDB 3TPZ X-ray; 2.10 A; A/B=1-273 # PDB 4ADV EM; 13.50 A; V=17-268 # PIR A24527 XYECRO # PROSITE PS01131 RRNA_A_DIMETH # PROSITE PS51689 SAM_RNA_A_N6_MT # Pfam PF00398 RrnaAD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RSMA_ECOLI Ribosomal RNA small subunit methyltransferase A # RefSeq NP_414593 NC_000913.3 # RefSeq WP_001065381 NZ_LN832404.1 # SIMILARITY Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily. {ECO 0000305}. # SMART SM00650 rADc # SUBCELLULAR LOCATION RSMA_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF53335 SSF53335 # TIGRFAMs TIGR00755 ksgA # eggNOG COG0030 LUCA # eggNOG ENOG4105D1X Bacteria BLAST swissprot:RSMA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RSMA_ECOLI BioCyc ECOL316407:JW0050-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0050-MONOMER BioCyc EcoCyc:EG10523-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10523-MONOMER BioCyc MetaCyc:EG10523-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10523-MONOMER COG COG0030 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0030 DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1007/BF00338091 http://dx.doi.org/10.1007/BF00338091 DOI 10.1016/0300-9084(87)90210-0 http://dx.doi.org/10.1016/0300-9084(87)90210-0 DOI 10.1016/0378-1119(85)90204-5 http://dx.doi.org/10.1016/0378-1119(85)90204-5 DOI 10.1016/j.jmb.2004.02.068 http://dx.doi.org/10.1016/j.jmb.2004.02.068 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M111.318121 http://dx.doi.org/10.1074/jbc.M111.318121 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1093/nar/gkp057 http://dx.doi.org/10.1093/nar/gkp057 DOI 10.1111/j.1365-2958.2008.06485.x http://dx.doi.org/10.1111/j.1365-2958.2008.06485.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01744-07 http://dx.doi.org/10.1128/JB.01744-07 EC_number EC:2.1.1.182 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.182 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M11054 http://www.ebi.ac.uk/ena/data/view/M11054 EMBL M68521 http://www.ebi.ac.uk/ena/data/view/M68521 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X04711 http://www.ebi.ac.uk/ena/data/view/X04711 EMBL X06536 http://www.ebi.ac.uk/ena/data/view/X06536 ENZYME 2.1.1.182 http://enzyme.expasy.org/EC/2.1.1.182 EchoBASE EB0518 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0518 EcoGene EG10523 http://www.ecogene.org/geneInfo.php?eg_id=EG10523 EnsemblBacteria AAC73162 http://www.ensemblgenomes.org/id/AAC73162 EnsemblBacteria AAC73162 http://www.ensemblgenomes.org/id/AAC73162 EnsemblBacteria BAE76038 http://www.ensemblgenomes.org/id/BAE76038 EnsemblBacteria BAE76038 http://www.ensemblgenomes.org/id/BAE76038 EnsemblBacteria BAE76038 http://www.ensemblgenomes.org/id/BAE76038 EnsemblBacteria b0051 http://www.ensemblgenomes.org/id/b0051 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000179 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000179 GO_function GO:0003690 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003690 GO_function GO:0003729 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003729 GO_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GO_function GO:0052908 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052908 GO_process GO:0000028 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000028 GO_process GO:0006364 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006364 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GO_process GO:0070475 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070475 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0003729 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003729 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0022618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022618 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.8.100 http://www.cathdb.info/version/latest/superfamily/1.10.8.100 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 GeneID 944939 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944939 HAMAP MF_00607 http://hamap.expasy.org/unirule/MF_00607 HOGENOM HOG000227962 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000227962&db=HOGENOM6 InParanoid P06992 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P06992 IntAct P06992 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P06992* IntEnz 2.1.1.182 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.182 InterPro IPR001737 http://www.ebi.ac.uk/interpro/entry/IPR001737 InterPro IPR011530 http://www.ebi.ac.uk/interpro/entry/IPR011530 InterPro IPR020596 http://www.ebi.ac.uk/interpro/entry/IPR020596 InterPro IPR020598 http://www.ebi.ac.uk/interpro/entry/IPR020598 InterPro IPR023165 http://www.ebi.ac.uk/interpro/entry/IPR023165 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW0050 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0050 KEGG_Gene eco:b0051 http://www.genome.jp/dbget-bin/www_bget?eco:b0051 KEGG_Orthology KO:K02528 http://www.genome.jp/dbget-bin/www_bget?KO:K02528 MINT MINT-1246440 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1246440 OMA VKANWYA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VKANWYA PANTHER PTHR11727 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11727 PDB 1QYR http://www.ebi.ac.uk/pdbe-srv/view/entry/1QYR PDB 3TPZ http://www.ebi.ac.uk/pdbe-srv/view/entry/3TPZ PDB 4ADV http://www.ebi.ac.uk/pdbe-srv/view/entry/4ADV PDBsum 1QYR http://www.ebi.ac.uk/pdbsum/1QYR PDBsum 3TPZ http://www.ebi.ac.uk/pdbsum/3TPZ PDBsum 4ADV http://www.ebi.ac.uk/pdbsum/4ADV PROSITE PS01131 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01131 PROSITE PS51689 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51689 PSORT swissprot:RSMA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RSMA_ECOLI PSORT-B swissprot:RSMA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RSMA_ECOLI PSORT2 swissprot:RSMA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RSMA_ECOLI Pfam PF00398 http://pfam.xfam.org/family/PF00398 Phobius swissprot:RSMA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RSMA_ECOLI PhylomeDB P06992 http://phylomedb.org/?seqid=P06992 ProteinModelPortal P06992 http://www.proteinmodelportal.org/query/uniprot/P06992 PubMed 15136037 http://www.ncbi.nlm.nih.gov/pubmed/15136037 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18223068 http://www.ncbi.nlm.nih.gov/pubmed/18223068 PubMed 18990185 http://www.ncbi.nlm.nih.gov/pubmed/18990185 PubMed 19223326 http://www.ncbi.nlm.nih.gov/pubmed/19223326 PubMed 22308031 http://www.ncbi.nlm.nih.gov/pubmed/22308031 PubMed 2670894 http://www.ncbi.nlm.nih.gov/pubmed/2670894 PubMed 3031429 http://www.ncbi.nlm.nih.gov/pubmed/3031429 PubMed 3122846 http://www.ncbi.nlm.nih.gov/pubmed/3122846 PubMed 3905517 http://www.ncbi.nlm.nih.gov/pubmed/3905517 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9748462 http://www.ncbi.nlm.nih.gov/pubmed/9748462 RefSeq NP_414593 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414593 RefSeq WP_001065381 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001065381 SMART SM00650 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00650 SMR P06992 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P06992 STRING 511145.b0051 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0051&targetmode=cogs STRING COG0030 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0030&targetmode=cogs SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 TIGRFAMs TIGR00755 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00755 UniProtKB RSMA_ECOLI http://www.uniprot.org/uniprot/RSMA_ECOLI UniProtKB-AC P06992 http://www.uniprot.org/uniprot/P06992 charge swissprot:RSMA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RSMA_ECOLI eggNOG COG0030 http://eggnogapi.embl.de/nog_data/html/tree/COG0030 eggNOG ENOG4105D1X http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D1X epestfind swissprot:RSMA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RSMA_ECOLI garnier swissprot:RSMA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RSMA_ECOLI helixturnhelix swissprot:RSMA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RSMA_ECOLI hmoment swissprot:RSMA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RSMA_ECOLI iep swissprot:RSMA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RSMA_ECOLI inforesidue swissprot:RSMA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RSMA_ECOLI octanol swissprot:RSMA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RSMA_ECOLI pepcoil swissprot:RSMA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RSMA_ECOLI pepdigest swissprot:RSMA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RSMA_ECOLI pepinfo swissprot:RSMA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RSMA_ECOLI pepnet swissprot:RSMA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RSMA_ECOLI pepstats swissprot:RSMA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RSMA_ECOLI pepwheel swissprot:RSMA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RSMA_ECOLI pepwindow swissprot:RSMA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RSMA_ECOLI sigcleave swissprot:RSMA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RSMA_ECOLI ## Database ID URL or Descriptions # FUNCTION IND12_ECOLI Involved in the transposition of the insertion sequence IS2. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006310 DNA recombination; IEA:UniProtKB-KW. # GO_process GO:0015074 DNA integration; IEA:InterPro. # GO_process GO:0032196 transposition; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 3.30.420.10 -; 1. # InterPro IPR001584 Integrase_cat-core # InterPro IPR012337 RNaseH-like_dom # InterPro IPR025948 HTH-like_dom # Organism IND12_ECOLI Escherichia coli (strain K12) # PATRIC 48661345 VBIEscCol107702_1042 # PROSITE PS50994 INTEGRASE # Pfam PF00665 rve # Pfam PF13276 HTH_21 # RecName IND12_ECOLI Transposase InsD for insertion element IS2-12 # SIMILARITY Contains 1 integrase catalytic domain. {ECO:0000255|PROSITE-ProRule PRU00457}. # SUPFAM SSF53098 SSF53098 # eggNOG ENOG4108MVM Bacteria # eggNOG ENOG410Z4Y8 LUCA BLAST swissprot:IND12_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:IND12_ECOLI DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EnsemblBacteria BAE77577 http://www.ensemblgenomes.org/id/BAE77577 EnsemblBacteria BAE77577 http://www.ensemblgenomes.org/id/BAE77577 EnsemblBacteria BAE77577 http://www.ensemblgenomes.org/id/BAE77577 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0015074 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015074 GO_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 3.30.420.10 http://www.cathdb.info/version/latest/superfamily/3.30.420.10 InterPro IPR001584 http://www.ebi.ac.uk/interpro/entry/IPR001584 InterPro IPR012337 http://www.ebi.ac.uk/interpro/entry/IPR012337 InterPro IPR025948 http://www.ebi.ac.uk/interpro/entry/IPR025948 KEGG_Gene ecj:JW5933 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5933 PROSITE PS50994 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50994 PSORT swissprot:IND12_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:IND12_ECOLI PSORT-B swissprot:IND12_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:IND12_ECOLI PSORT2 swissprot:IND12_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:IND12_ECOLI Pfam PF00665 http://pfam.xfam.org/family/PF00665 Pfam PF13276 http://pfam.xfam.org/family/PF13276 Phobius swissprot:IND12_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:IND12_ECOLI PhylomeDB P0CF64 http://phylomedb.org/?seqid=P0CF64 ProteinModelPortal P0CF64 http://www.proteinmodelportal.org/query/uniprot/P0CF64 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 SMR P0CF64 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0CF64 STRING 511145.b4273 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4273&targetmode=cogs SUPFAM SSF53098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098 UniProtKB IND12_ECOLI http://www.uniprot.org/uniprot/IND12_ECOLI UniProtKB-AC P0CF64 http://www.uniprot.org/uniprot/P0CF64 charge swissprot:IND12_ECOLI http://rest.g-language.org/emboss/charge/swissprot:IND12_ECOLI eggNOG ENOG4108MVM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MVM eggNOG ENOG410Z4Y8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Z4Y8 epestfind swissprot:IND12_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:IND12_ECOLI garnier swissprot:IND12_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:IND12_ECOLI helixturnhelix swissprot:IND12_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:IND12_ECOLI hmoment swissprot:IND12_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:IND12_ECOLI iep swissprot:IND12_ECOLI http://rest.g-language.org/emboss/iep/swissprot:IND12_ECOLI inforesidue swissprot:IND12_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:IND12_ECOLI octanol swissprot:IND12_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:IND12_ECOLI pepcoil swissprot:IND12_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:IND12_ECOLI pepdigest swissprot:IND12_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:IND12_ECOLI pepinfo swissprot:IND12_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:IND12_ECOLI pepnet swissprot:IND12_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:IND12_ECOLI pepstats swissprot:IND12_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:IND12_ECOLI pepwheel swissprot:IND12_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:IND12_ECOLI pepwindow swissprot:IND12_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:IND12_ECOLI sigcleave swissprot:IND12_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:IND12_ECOLI ## Database ID URL or Descriptions # BioGrid 4259789 7 # EcoGene EG13561 ecpE # FUNCTION ECPE_ECOLI Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition (By similarity). {ECO 0000250}. # INDUCTION Negatively regulated by H-NS. Positively regulated by IHF and EcpR (By similarity). {ECO 0000250}. # InterPro IPR008962 PapD-like # MISCELLANEOUS Not expressed under classical laboratory conditions, but is functional when constitutively expressed. {ECO:0000305|PubMed 20522494}. # Organism ECPE_ECOLI Escherichia coli (strain K12) # PATRIC 32115701 VBIEscCol129921_0293 # PIR A64755 A64755 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ECPE_ECOLI Probable fimbrial chaperone EcpE # RefSeq NP_414823 NC_000913.3 # RefSeq WP_001350485 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18018.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the EcpB/EcpE family. {ECO 0000305}. # SUPFAM SSF49354 SSF49354 # eggNOG ENOG4108UD7 Bacteria # eggNOG ENOG4111HA8 LUCA BLAST swissprot:ECPE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ECPE_ECOLI BioCyc ECOL316407:JW5030-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5030-MONOMER BioCyc EcoCyc:G6160-MONOMER http://biocyc.org/getid?id=EcoCyc:G6160-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1099/mic.0.039610-0 http://dx.doi.org/10.1099/mic.0.039610-0 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB3331 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3331 EcoGene EG13561 http://www.ecogene.org/geneInfo.php?eg_id=EG13561 EnsemblBacteria AAC73392 http://www.ensemblgenomes.org/id/AAC73392 EnsemblBacteria AAC73392 http://www.ensemblgenomes.org/id/AAC73392 EnsemblBacteria BAE76073 http://www.ensemblgenomes.org/id/BAE76073 EnsemblBacteria BAE76073 http://www.ensemblgenomes.org/id/BAE76073 EnsemblBacteria BAE76073 http://www.ensemblgenomes.org/id/BAE76073 EnsemblBacteria b0289 http://www.ensemblgenomes.org/id/b0289 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946631 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946631 HOGENOM HOG000269457 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000269457&db=HOGENOM6 InterPro IPR008962 http://www.ebi.ac.uk/interpro/entry/IPR008962 KEGG_Gene ecj:JW5030 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5030 KEGG_Gene eco:b0289 http://www.genome.jp/dbget-bin/www_bget?eco:b0289 OMA MEPVVVM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MEPVVVM PSORT swissprot:ECPE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ECPE_ECOLI PSORT-B swissprot:ECPE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ECPE_ECOLI PSORT2 swissprot:ECPE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ECPE_ECOLI Phobius swissprot:ECPE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ECPE_ECOLI ProteinModelPortal P77263 http://www.proteinmodelportal.org/query/uniprot/P77263 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20522494 http://www.ncbi.nlm.nih.gov/pubmed/20522494 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414823 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414823 RefSeq WP_001350485 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001350485 STRING 511145.b0289 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0289&targetmode=cogs SUPFAM SSF49354 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49354 UniProtKB ECPE_ECOLI http://www.uniprot.org/uniprot/ECPE_ECOLI UniProtKB-AC P77263 http://www.uniprot.org/uniprot/P77263 charge swissprot:ECPE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ECPE_ECOLI eggNOG ENOG4108UD7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UD7 eggNOG ENOG4111HA8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111HA8 epestfind swissprot:ECPE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ECPE_ECOLI garnier swissprot:ECPE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ECPE_ECOLI helixturnhelix swissprot:ECPE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ECPE_ECOLI hmoment swissprot:ECPE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ECPE_ECOLI iep swissprot:ECPE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ECPE_ECOLI inforesidue swissprot:ECPE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ECPE_ECOLI octanol swissprot:ECPE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ECPE_ECOLI pepcoil swissprot:ECPE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ECPE_ECOLI pepdigest swissprot:ECPE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ECPE_ECOLI pepinfo swissprot:ECPE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ECPE_ECOLI pepnet swissprot:ECPE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ECPE_ECOLI pepstats swissprot:ECPE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ECPE_ECOLI pepwheel swissprot:ECPE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ECPE_ECOLI pepwindow swissprot:ECPE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ECPE_ECOLI sigcleave swissprot:ECPE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ECPE_ECOLI ## Database ID URL or Descriptions # AltName FADM_ECOLI Acyl-CoA thioester hydrolase # AltName FADM_ECOLI Thioesterase 3 # BIOPHYSICOCHEMICAL PROPERTIES FADM_ECOLI Kinetic parameters KM=3.0 uM for 3,5-cis-tetradecadienoyl-CoA {ECO 0000269|PubMed 18576672}; KM=10.8 uM for 3,5-cis-dodecadienoyl-CoA {ECO 0000269|PubMed 18576672}; KM=5.8 uM for 3-hydroxytetradecanoyl-CoA {ECO 0000269|PubMed 18576672}; KM=6.0 uM for palmitoyl-CoA {ECO 0000269|PubMed 18576672}; KM=6.3 uM for myristoyl-CoA {ECO 0000269|PubMed 18576672}; KM=13.0 uM for lauroyl-CoA {ECO 0000269|PubMed 18576672}; Vmax=101.3 umol/min/mg enzyme with 3,5-cis-tetradecadienoyl-CoA as substrate {ECO 0000269|PubMed 18576672}; Vmax=92.3 umol/min/mg enzyme with 3,5-cis-dodecadienoyl-CoA as substrate {ECO 0000269|PubMed 18576672}; Vmax=45.5 umol/min/mg enzyme with 3-hydroxytetradecanoyl-CoA as substrate {ECO 0000269|PubMed 18576672}; Vmax=43.5 umol/min/mg enzyme with palmitoyl-CoA as substrate {ECO 0000269|PubMed 18576672}; Vmax=26.4 umol/min/mg enzyme with myristoyl-CoA as substrate {ECO 0000269|PubMed 18576672}; Vmax=6.9 umol/min/mg enzyme with lauroyl-CoA as substrate {ECO 0000269|PubMed 18576672}; # BRENDA 3.1.2.20 2026 # BioGrid 4259836 162 # EcoGene EG13251 fadM # FUNCTION FADM_ECOLI Long-chain acyl-CoA thioesterase with a preference for 3,5-tetradecadienoyl-CoA. Could be involved in beta-oxidation of fatty acids. {ECO 0000269|PubMed 18576672}. # GO_function GO:0047617 acyl-CoA hydrolase activity; IDA:EcoCyc. # GO_process GO:0006635 fatty acid beta-oxidation; IEP:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.10.129.10 -; 1. # INDUCTION FADM_ECOLI Up-regulated by growth on oleic acid. Repressed by FadR and by the cyclic AMP receptor protein-cAMP (CRP-cAMP) complex. {ECO 0000269|PubMed 18576672, ECO 0000269|PubMed 19684132}. # IntAct P77712 4 # InterPro IPR006684 YbgC/YbaW # InterPro IPR029069 HotDog_dom # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01004 Lipid biosynthesis proteins # Organism FADM_ECOLI Escherichia coli (strain K12) # PATRIC 32116039 VBIEscCol129921_0461 # PDB 1NJK X-ray; 1.90 A; A/B/C/D=1-132 # PIR C64774 C64774 # PIRSF PIRSF003230 YbgC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FADM_ECOLI Long-chain acyl-CoA thioesterase FadM # RefSeq NP_414977 NC_000913.3 # RefSeq WP_001194534 NZ_LN832404.1 # SIMILARITY Belongs to the 4-hydroxybenzoyl-CoA thioesterase family. {ECO 0000305}. # SUBUNIT Homotetramer. {ECO 0000305}. # SUPFAM SSF54637 SSF54637 # TIGRFAMs TIGR00051 TIGR00051 # eggNOG COG0824 LUCA # eggNOG ENOG4108TGP Bacteria BLAST swissprot:FADM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FADM_ECOLI BioCyc ECOL316407:JW0433-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0433-MONOMER BioCyc EcoCyc:G6244-MONOMER http://biocyc.org/getid?id=EcoCyc:G6244-MONOMER BioCyc MetaCyc:G6244-MONOMER http://biocyc.org/getid?id=MetaCyc:G6244-MONOMER COG COG0824 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0824 DOI 10.1021/bi800595f http://dx.doi.org/10.1021/bi800595f DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00835-09 http://dx.doi.org/10.1128/JB.00835-09 EC_number EC:3.1.2.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.2.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D82943 http://www.ebi.ac.uk/ena/data/view/D82943 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 ENZYME 3.1.2.- http://enzyme.expasy.org/EC/3.1.2.- EchoBASE EB3040 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3040 EcoGene EG13251 http://www.ecogene.org/geneInfo.php?eg_id=EG13251 EnsemblBacteria AAC73546 http://www.ensemblgenomes.org/id/AAC73546 EnsemblBacteria AAC73546 http://www.ensemblgenomes.org/id/AAC73546 EnsemblBacteria BAE76223 http://www.ensemblgenomes.org/id/BAE76223 EnsemblBacteria BAE76223 http://www.ensemblgenomes.org/id/BAE76223 EnsemblBacteria BAE76223 http://www.ensemblgenomes.org/id/BAE76223 EnsemblBacteria b0443 http://www.ensemblgenomes.org/id/b0443 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0047617 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047617 GO_process GO:0006635 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006635 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.10.129.10 http://www.cathdb.info/version/latest/superfamily/3.10.129.10 GeneID 945812 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945812 HOGENOM HOG000004132 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000004132&db=HOGENOM6 InParanoid P77712 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77712 IntAct P77712 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77712* IntEnz 3.1.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.2 InterPro IPR006684 http://www.ebi.ac.uk/interpro/entry/IPR006684 InterPro IPR029069 http://www.ebi.ac.uk/interpro/entry/IPR029069 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01004 http://www.genome.jp/dbget-bin/www_bget?ko01004 KEGG_Gene ecj:JW0433 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0433 KEGG_Gene eco:b0443 http://www.genome.jp/dbget-bin/www_bget?eco:b0443 KEGG_Orthology KO:K12500 http://www.genome.jp/dbget-bin/www_bget?KO:K12500 OMA ANININY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ANININY PDB 1NJK http://www.ebi.ac.uk/pdbe-srv/view/entry/1NJK PDBsum 1NJK http://www.ebi.ac.uk/pdbsum/1NJK PSORT swissprot:FADM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FADM_ECOLI PSORT-B swissprot:FADM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FADM_ECOLI PSORT2 swissprot:FADM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FADM_ECOLI Phobius swissprot:FADM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FADM_ECOLI ProteinModelPortal P77712 http://www.proteinmodelportal.org/query/uniprot/P77712 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18576672 http://www.ncbi.nlm.nih.gov/pubmed/18576672 PubMed 19684132 http://www.ncbi.nlm.nih.gov/pubmed/19684132 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414977 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414977 RefSeq WP_001194534 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001194534 SMR P77712 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77712 STRING 511145.b0443 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0443&targetmode=cogs STRING COG0824 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0824&targetmode=cogs SUPFAM SSF54637 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54637 TIGRFAMs TIGR00051 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00051 UniProtKB FADM_ECOLI http://www.uniprot.org/uniprot/FADM_ECOLI UniProtKB-AC P77712 http://www.uniprot.org/uniprot/P77712 charge swissprot:FADM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FADM_ECOLI eggNOG COG0824 http://eggnogapi.embl.de/nog_data/html/tree/COG0824 eggNOG ENOG4108TGP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108TGP epestfind swissprot:FADM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FADM_ECOLI garnier swissprot:FADM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FADM_ECOLI helixturnhelix swissprot:FADM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FADM_ECOLI hmoment swissprot:FADM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FADM_ECOLI iep swissprot:FADM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FADM_ECOLI inforesidue swissprot:FADM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FADM_ECOLI octanol swissprot:FADM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FADM_ECOLI pepcoil swissprot:FADM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FADM_ECOLI pepdigest swissprot:FADM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FADM_ECOLI pepinfo swissprot:FADM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FADM_ECOLI pepnet swissprot:FADM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FADM_ECOLI pepstats swissprot:FADM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FADM_ECOLI pepwheel swissprot:FADM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FADM_ECOLI pepwindow swissprot:FADM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FADM_ECOLI sigcleave swissprot:FADM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FADM_ECOLI ## Database ID URL or Descriptions # BioGrid 4260326 14 # EcoGene EG13498 yeaL # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # HAMAP MF_01874 UPF0756 # InterPro IPR007382 UPF0756_TM # Organism YEAL_ECOLI Escherichia coli (strain K12) # PATRIC 32118891 VBIEscCol129921_1863 # PIR E64939 E64939 # Pfam PF04284 DUF441 # ProDom PD021096 DUF441_TM # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UPF0756 membrane protein YeaL {ECO:0000255|HAMAP-Rule MF_01874} # RefSeq NP_416303 NC_000913.3 # RefSeq WP_000460707 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0756 family. {ECO:0000255|HAMAP- Rule MF_01874}. # SUBCELLULAR LOCATION YEAL_ECOLI Cell membrane {ECO 0000255|HAMAP- Rule MF_01874}; Multi-pass membrane protein {ECO 0000255|HAMAP- Rule MF_01874}. # eggNOG COG2707 LUCA # eggNOG ENOG4108VMM Bacteria BLAST swissprot:YEAL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEAL_ECOLI BioCyc ECOL316407:JW1778-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1778-MONOMER BioCyc EcoCyc:G6975-MONOMER http://biocyc.org/getid?id=EcoCyc:G6975-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3271 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3271 EcoGene EG13498 http://www.ecogene.org/geneInfo.php?eg_id=EG13498 EnsemblBacteria AAC74859 http://www.ensemblgenomes.org/id/AAC74859 EnsemblBacteria AAC74859 http://www.ensemblgenomes.org/id/AAC74859 EnsemblBacteria BAA15588 http://www.ensemblgenomes.org/id/BAA15588 EnsemblBacteria BAA15588 http://www.ensemblgenomes.org/id/BAA15588 EnsemblBacteria BAA15588 http://www.ensemblgenomes.org/id/BAA15588 EnsemblBacteria b1789 http://www.ensemblgenomes.org/id/b1789 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 946307 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946307 HAMAP MF_01874 http://hamap.expasy.org/unirule/MF_01874 HOGENOM HOG000021336 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000021336&db=HOGENOM6 InParanoid P0ACY6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACY6 InterPro IPR007382 http://www.ebi.ac.uk/interpro/entry/IPR007382 KEGG_Gene ecj:JW1778 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1778 KEGG_Gene eco:b1789 http://www.genome.jp/dbget-bin/www_bget?eco:b1789 OMA SKGINWG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SKGINWG PSORT swissprot:YEAL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEAL_ECOLI PSORT-B swissprot:YEAL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEAL_ECOLI PSORT2 swissprot:YEAL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEAL_ECOLI Pfam PF04284 http://pfam.xfam.org/family/PF04284 Phobius swissprot:YEAL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEAL_ECOLI PhylomeDB P0ACY6 http://phylomedb.org/?seqid=P0ACY6 ProteinModelPortal P0ACY6 http://www.proteinmodelportal.org/query/uniprot/P0ACY6 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416303 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416303 RefSeq WP_000460707 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000460707 STRING 511145.b1789 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1789&targetmode=cogs UniProtKB YEAL_ECOLI http://www.uniprot.org/uniprot/YEAL_ECOLI UniProtKB-AC P0ACY6 http://www.uniprot.org/uniprot/P0ACY6 charge swissprot:YEAL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEAL_ECOLI eggNOG COG2707 http://eggnogapi.embl.de/nog_data/html/tree/COG2707 eggNOG ENOG4108VMM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108VMM epestfind swissprot:YEAL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEAL_ECOLI garnier swissprot:YEAL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEAL_ECOLI helixturnhelix swissprot:YEAL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEAL_ECOLI hmoment swissprot:YEAL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEAL_ECOLI iep swissprot:YEAL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEAL_ECOLI inforesidue swissprot:YEAL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEAL_ECOLI octanol swissprot:YEAL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEAL_ECOLI pepcoil swissprot:YEAL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEAL_ECOLI pepdigest swissprot:YEAL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEAL_ECOLI pepinfo swissprot:YEAL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEAL_ECOLI pepnet swissprot:YEAL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEAL_ECOLI pepstats swissprot:YEAL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEAL_ECOLI pepwheel swissprot:YEAL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEAL_ECOLI pepwindow swissprot:YEAL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEAL_ECOLI sigcleave swissprot:YEAL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEAL_ECOLI ## Database ID URL or Descriptions # AltName RLUC_ECOLI 23S rRNA pseudouridine(955/2504/2580) synthase # AltName RLUC_ECOLI rRNA pseudouridylate synthase C # AltName RLUC_ECOLI rRNA-uridine isomerase C # BRENDA 5.4.99.24 2026 # BioGrid 4261025 9 # CATALYTIC ACTIVITY 23S rRNA uridine(955)/uridine(2504)/uridine(2580) = 23S rRNA pseudouridine(955)/pseudouridine(2504)/pseudouridine(2580). {ECO:0000269|PubMed 9660827}. # DISRUPTION PHENOTYPE No visible phenotype. {ECO:0000269|PubMed 9660827}. # EcoGene EG11118 rluC # FUNCTION RLUC_ECOLI Responsible for synthesis of pseudouridine from uracil at positions 955, 2504 and 2580 in 23S ribosomal RNA. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003723 RNA binding; IEA:UniProtKB-KW. # GO_function GO:0009982 pseudouridine synthase activity; IDA:EcoCyc. # GO_process GO:0000455 enzyme-directed rRNA pseudouridine synthesis; IDA:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.10.290.10 -; 1. # IntAct P0AA39 70 # InterPro IPR002942 S4_RNA-bd # InterPro IPR006145 PsdUridine_synth_RsuA/RluD # InterPro IPR006224 PsdUridine_synth_RluC/D_CS # InterPro IPR006225 PsdUridine_synth_RluC/D # InterPro IPR020103 PsdUridine_synth_cat_dom # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # Organism RLUC_ECOLI Escherichia coli (strain K12) # PATRIC 32117413 VBIEscCol129921_1129 # PDB 1V9K X-ray; 2.00 A; A/B=92-319 # PDB 1XPI X-ray; 2.20 A; A/B=89-319 # PIR C64852 C64852 # PROSITE PS01129 PSI_RLU # PROSITE PS50889 S4 # Pfam PF00849 PseudoU_synth_2 # Pfam PF01479 S4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RLUC_ECOLI Ribosomal large subunit pseudouridine synthase C # RefSeq NP_415604 NC_000913.3 # RefSeq WP_000846343 NZ_LN832404.1 # SIMILARITY Belongs to the pseudouridine synthase RluA family. {ECO 0000305}. # SIMILARITY Contains 1 S4 RNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00182}. # SMART SM00363 S4 # SUPFAM SSF55120 SSF55120 # TIGRFAMs TIGR00005 rluA_subfam # eggNOG COG0564 LUCA # eggNOG ENOG4105EI2 Bacteria BLAST swissprot:RLUC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RLUC_ECOLI BioCyc ECOL316407:JW1072-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1072-MONOMER BioCyc EcoCyc:EG11118-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11118-MONOMER BioCyc MetaCyc:EG11118-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11118-MONOMER COG COG0564 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0564 DIP DIP-47832N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47832N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.273.29.18562 http://dx.doi.org/10.1074/jbc.273.29.18562 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1107/S090744499801021X http://dx.doi.org/10.1107/S090744499801021X DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.4.99.24 http://www.genome.jp/dbget-bin/www_bget?EC:5.4.99.24 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M62747 http://www.ebi.ac.uk/ena/data/view/M62747 EMBL M96791 http://www.ebi.ac.uk/ena/data/view/M96791 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 5.4.99.24 http://enzyme.expasy.org/EC/5.4.99.24 EchoBASE EB1108 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1108 EcoGene EG11118 http://www.ecogene.org/geneInfo.php?eg_id=EG11118 EnsemblBacteria AAC74170 http://www.ensemblgenomes.org/id/AAC74170 EnsemblBacteria AAC74170 http://www.ensemblgenomes.org/id/AAC74170 EnsemblBacteria BAA35894 http://www.ensemblgenomes.org/id/BAA35894 EnsemblBacteria BAA35894 http://www.ensemblgenomes.org/id/BAA35894 EnsemblBacteria BAA35894 http://www.ensemblgenomes.org/id/BAA35894 EnsemblBacteria b1086 http://www.ensemblgenomes.org/id/b1086 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0009982 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009982 GO_process GO:0000455 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000455 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.10.290.10 http://www.cathdb.info/version/latest/superfamily/3.10.290.10 GeneID 945637 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945637 HOGENOM HOG000275914 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275914&db=HOGENOM6 InParanoid P0AA39 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AA39 IntAct P0AA39 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AA39* IntEnz 5.4.99.24 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.4.99.24 InterPro IPR002942 http://www.ebi.ac.uk/interpro/entry/IPR002942 InterPro IPR006145 http://www.ebi.ac.uk/interpro/entry/IPR006145 InterPro IPR006224 http://www.ebi.ac.uk/interpro/entry/IPR006224 InterPro IPR006225 http://www.ebi.ac.uk/interpro/entry/IPR006225 InterPro IPR020103 http://www.ebi.ac.uk/interpro/entry/IPR020103 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW1072 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1072 KEGG_Gene eco:b1086 http://www.genome.jp/dbget-bin/www_bget?eco:b1086 KEGG_Orthology KO:K06179 http://www.genome.jp/dbget-bin/www_bget?KO:K06179 OMA EAPMDEQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EAPMDEQ PDB 1V9K http://www.ebi.ac.uk/pdbe-srv/view/entry/1V9K PDB 1XPI http://www.ebi.ac.uk/pdbe-srv/view/entry/1XPI PDBsum 1V9K http://www.ebi.ac.uk/pdbsum/1V9K PDBsum 1XPI http://www.ebi.ac.uk/pdbsum/1XPI PROSITE PS01129 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01129 PROSITE PS50889 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50889 PSORT swissprot:RLUC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RLUC_ECOLI PSORT-B swissprot:RLUC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RLUC_ECOLI PSORT2 swissprot:RLUC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RLUC_ECOLI Pfam PF00849 http://pfam.xfam.org/family/PF00849 Pfam PF01479 http://pfam.xfam.org/family/PF01479 Phobius swissprot:RLUC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RLUC_ECOLI PhylomeDB P0AA39 http://phylomedb.org/?seqid=P0AA39 ProteinModelPortal P0AA39 http://www.proteinmodelportal.org/query/uniprot/P0AA39 PubMed 10089432 http://www.ncbi.nlm.nih.gov/pubmed/10089432 PubMed 1447160 http://www.ncbi.nlm.nih.gov/pubmed/1447160 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1704367 http://www.ncbi.nlm.nih.gov/pubmed/1704367 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9660827 http://www.ncbi.nlm.nih.gov/pubmed/9660827 RefSeq NP_415604 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415604 RefSeq WP_000846343 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000846343 SMART SM00363 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00363 SMR P0AA39 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AA39 STRING 511145.b1086 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1086&targetmode=cogs STRING COG0564 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0564&targetmode=cogs SUPFAM SSF55120 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55120 TIGRFAMs TIGR00005 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00005 UniProtKB RLUC_ECOLI http://www.uniprot.org/uniprot/RLUC_ECOLI UniProtKB-AC P0AA39 http://www.uniprot.org/uniprot/P0AA39 charge swissprot:RLUC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RLUC_ECOLI eggNOG COG0564 http://eggnogapi.embl.de/nog_data/html/tree/COG0564 eggNOG ENOG4105EI2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EI2 epestfind swissprot:RLUC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RLUC_ECOLI garnier swissprot:RLUC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RLUC_ECOLI helixturnhelix swissprot:RLUC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RLUC_ECOLI hmoment swissprot:RLUC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RLUC_ECOLI iep swissprot:RLUC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RLUC_ECOLI inforesidue swissprot:RLUC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RLUC_ECOLI octanol swissprot:RLUC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RLUC_ECOLI pepcoil swissprot:RLUC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RLUC_ECOLI pepdigest swissprot:RLUC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RLUC_ECOLI pepinfo swissprot:RLUC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RLUC_ECOLI pepnet swissprot:RLUC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RLUC_ECOLI pepstats swissprot:RLUC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RLUC_ECOLI pepwheel swissprot:RLUC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RLUC_ECOLI pepwindow swissprot:RLUC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RLUC_ECOLI sigcleave swissprot:RLUC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RLUC_ECOLI ## Database ID URL or Descriptions # AltName Aspartyl-tRNA synthetase {ECO:0000255|HAMAP-Rule MF_00044} # BRENDA 6.1.1.12 2026 # BioGrid 4259330 10 # CATALYTIC ACTIVITY ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). {ECO:0000255|HAMAP- Rule MF_00044}. # EcoGene EG10097 aspS # FUNCTION SYD_ECOLI Catalyzes the attachment of glutamate to tRNA(Asp) in a two-step reaction aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp). {ECO 0000255|HAMAP-Rule MF_00044}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0003676 nucleic acid binding; IEA:InterPro. # GO_function GO:0004815 aspartate-tRNA ligase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0006422 aspartyl-tRNA aminoacylation; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0006520 cellular amino acid metabolic process # Gene3D 3.30.1360.30 -; 1. # HAMAP MF_00044 Asp_tRNA_synth_type1 # IntAct P21889 26 # InterPro IPR002312 Asp/Asn-tRNA-synth_IIb # InterPro IPR004115 GAD-like # InterPro IPR004364 aa-tRNA-synt_II # InterPro IPR004365 NA-bd_OB_tRNA # InterPro IPR004524 Asp-tRNA-ligase_bac/mit # InterPro IPR006195 aa-tRNA-synth_II # InterPro IPR012340 NA-bd_OB-fold # InterPro IPR018150 aa-tRNA-synt_II-like # InterPro IPR029351 GAD_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01007 Amino acid related enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # KEGG_Pathway ko00970 Aminoacyl-tRNA biosynthesis # Organism SYD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR22594 PTHR22594; 2 # PANTHER PTHR22594:SF5 PTHR22594:SF5; 2 # PATRIC 32119055 VBIEscCol129921_1945 # PDB 1C0A X-ray; 2.40 A; A=1-585 # PDB 1EQR X-ray; 2.70 A; A/B/C=1-590 # PDB 1IL2 X-ray; 2.60 A; A/B=1-590 # PIR JT0942 SYECD # PRINTS PR01042 TRNASYNTHASP # PROSITE PS50862 AA_TRNA_LIGASE_II # Pfam PF00152 tRNA-synt_2 # Pfam PF01336 tRNA_anti-codon # Pfam PF02938 GAD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Aspartate--tRNA ligase {ECO:0000255|HAMAP-Rule MF_00044} # RefSeq NP_416380 NC_000913.3 # RefSeq WP_001258678 NZ_LN832404.1 # SIMILARITY Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. {ECO:0000255|HAMAP-Rule MF_00044}. # SUBCELLULAR LOCATION SYD_ECOLI Cytoplasm. # SUBUNIT SYD_ECOLI Homodimer. # SUPFAM SSF50249 SSF50249 # SUPFAM SSF55261 SSF55261 # TIGRFAMs TIGR00459 aspS_bact # eggNOG COG0173 LUCA # eggNOG ENOG4105C9M Bacteria BLAST swissprot:SYD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SYD_ECOLI BioCyc ECOL316407:JW1855-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1855-MONOMER BioCyc EcoCyc:ASPS-MONOMER http://biocyc.org/getid?id=EcoCyc:ASPS-MONOMER BioCyc MetaCyc:ASPS-MONOMER http://biocyc.org/getid?id=MetaCyc:ASPS-MONOMER COG COG0017 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0017 COG COG0173 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0173 DIP DIP-9182N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9182N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/jmbi.2000.3792 http://dx.doi.org/10.1006/jmbi.2000.3792 DOI 10.1016/0165-7992(91)90122-K http://dx.doi.org/10.1016/0165-7992(91)90122-K DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/emboj/18.22.6532 http://dx.doi.org/10.1093/emboj/18.22.6532 DOI 10.1093/nar/18.23.7109 http://dx.doi.org/10.1093/nar/18.23.7109 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.1.1.12 {ECO:0000255|HAMAP-Rule:MF_00044} http://www.genome.jp/dbget-bin/www_bget?EC:6.1.1.12 {ECO:0000255|HAMAP-Rule:MF_00044} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D10165 http://www.ebi.ac.uk/ena/data/view/D10165 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X53863 http://www.ebi.ac.uk/ena/data/view/X53863 EMBL X53984 http://www.ebi.ac.uk/ena/data/view/X53984 ENZYME 6.1.1.12 {ECO:0000255|HAMAP-Rule:MF_00044} http://enzyme.expasy.org/EC/6.1.1.12 {ECO:0000255|HAMAP-Rule:MF_00044} EchoBASE EB0095 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0095 EcoGene EG10097 http://www.ecogene.org/geneInfo.php?eg_id=EG10097 EnsemblBacteria AAC74936 http://www.ensemblgenomes.org/id/AAC74936 EnsemblBacteria AAC74936 http://www.ensemblgenomes.org/id/AAC74936 EnsemblBacteria BAA15677 http://www.ensemblgenomes.org/id/BAA15677 EnsemblBacteria BAA15677 http://www.ensemblgenomes.org/id/BAA15677 EnsemblBacteria BAA15677 http://www.ensemblgenomes.org/id/BAA15677 EnsemblBacteria b1866 http://www.ensemblgenomes.org/id/b1866 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003676 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003676 GO_function GO:0004815 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004815 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006422 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006422 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 Gene3D 3.30.1360.30 http://www.cathdb.info/version/latest/superfamily/3.30.1360.30 GeneID 946385 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946385 HAMAP MF_00044 http://hamap.expasy.org/unirule/MF_00044 HOGENOM HOG000275159 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275159&db=HOGENOM6 InParanoid P21889 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P21889 IntAct P21889 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P21889* IntEnz 6.1.1.12 {ECO:0000255|HAMAP-Rule:MF_00044} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.1.1.12 {ECO:0000255|HAMAP-Rule:MF_00044} InterPro IPR002312 http://www.ebi.ac.uk/interpro/entry/IPR002312 InterPro IPR004115 http://www.ebi.ac.uk/interpro/entry/IPR004115 InterPro IPR004364 http://www.ebi.ac.uk/interpro/entry/IPR004364 InterPro IPR004365 http://www.ebi.ac.uk/interpro/entry/IPR004365 InterPro IPR004524 http://www.ebi.ac.uk/interpro/entry/IPR004524 InterPro IPR006195 http://www.ebi.ac.uk/interpro/entry/IPR006195 InterPro IPR012340 http://www.ebi.ac.uk/interpro/entry/IPR012340 InterPro IPR018150 http://www.ebi.ac.uk/interpro/entry/IPR018150 InterPro IPR029351 http://www.ebi.ac.uk/interpro/entry/IPR029351 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW1855 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1855 KEGG_Gene eco:b1866 http://www.genome.jp/dbget-bin/www_bget?eco:b1866 KEGG_Orthology KO:K01876 http://www.genome.jp/dbget-bin/www_bget?KO:K01876 KEGG_Pathway ko00970 http://www.genome.jp/kegg-bin/show_pathway?ko00970 KEGG_Reaction rn:R05577 http://www.genome.jp/dbget-bin/www_bget?rn:R05577 MINT MINT-1249167 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1249167 OMA YQLDVEM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YQLDVEM PANTHER PTHR22594 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22594 PANTHER PTHR22594:SF5 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22594:SF5 PDB 1C0A http://www.ebi.ac.uk/pdbe-srv/view/entry/1C0A PDB 1EQR http://www.ebi.ac.uk/pdbe-srv/view/entry/1EQR PDB 1IL2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1IL2 PDBsum 1C0A http://www.ebi.ac.uk/pdbsum/1C0A PDBsum 1EQR http://www.ebi.ac.uk/pdbsum/1EQR PDBsum 1IL2 http://www.ebi.ac.uk/pdbsum/1IL2 PRINTS PR01042 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01042 PROSITE PS50862 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50862 PSORT swissprot:SYD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SYD_ECOLI PSORT-B swissprot:SYD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SYD_ECOLI PSORT2 swissprot:SYD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SYD_ECOLI Pfam PF00152 http://pfam.xfam.org/family/PF00152 Pfam PF01336 http://pfam.xfam.org/family/PF01336 Pfam PF02938 http://pfam.xfam.org/family/PF02938 Phobius swissprot:SYD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SYD_ECOLI PhylomeDB P21889 http://phylomedb.org/?seqid=P21889 ProteinModelPortal P21889 http://www.proteinmodelportal.org/query/uniprot/P21889 PubMed 10562565 http://www.ncbi.nlm.nih.gov/pubmed/10562565 PubMed 10873442 http://www.ncbi.nlm.nih.gov/pubmed/10873442 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1885548 http://www.ncbi.nlm.nih.gov/pubmed/1885548 PubMed 1944398 http://www.ncbi.nlm.nih.gov/pubmed/1944398 PubMed 2129559 http://www.ncbi.nlm.nih.gov/pubmed/2129559 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_416380 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416380 RefSeq WP_001258678 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001258678 SMR P21889 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P21889 STRING 511145.b1866 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1866&targetmode=cogs STRING COG0017 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0017&targetmode=cogs STRING COG0173 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0173&targetmode=cogs SUPFAM SSF50249 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50249 SUPFAM SSF55261 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55261 SWISS-2DPAGE P21889 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P21889 TIGRFAMs TIGR00459 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00459 UniProtKB SYD_ECOLI http://www.uniprot.org/uniprot/SYD_ECOLI UniProtKB-AC P21889 http://www.uniprot.org/uniprot/P21889 charge swissprot:SYD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SYD_ECOLI eggNOG COG0173 http://eggnogapi.embl.de/nog_data/html/tree/COG0173 eggNOG ENOG4105C9M http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C9M epestfind swissprot:SYD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SYD_ECOLI garnier swissprot:SYD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SYD_ECOLI helixturnhelix swissprot:SYD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SYD_ECOLI hmoment swissprot:SYD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SYD_ECOLI iep swissprot:SYD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SYD_ECOLI inforesidue swissprot:SYD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SYD_ECOLI octanol swissprot:SYD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SYD_ECOLI pepcoil swissprot:SYD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SYD_ECOLI pepdigest swissprot:SYD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SYD_ECOLI pepinfo swissprot:SYD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SYD_ECOLI pepnet swissprot:SYD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SYD_ECOLI pepstats swissprot:SYD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SYD_ECOLI pepwheel swissprot:SYD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SYD_ECOLI pepwindow swissprot:SYD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SYD_ECOLI sigcleave swissprot:SYD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SYD_ECOLI ## Database ID URL or Descriptions # AltName PABC_ECOLI 4-amino-4-deoxychorismate lyase # BRENDA 4.1.3.38 2026 # BioGrid 4259420 470 # CATALYTIC ACTIVITY 4-amino-4-deoxychorismate = 4-aminobenzoate + pyruvate. {ECO:0000269|PubMed 2251281}. # CDD cd01559 ADCL_like # COFACTOR PABC_ECOLI Name=pyridoxal 5'-phosphate; Xref=ChEBI CHEBI 597326; Evidence={ECO 0000269|PubMed 10876155, ECO 0000269|PubMed 11841211, ECO 0000269|PubMed 1644759}; # DISRUPTION PHENOTYPE Cells lacking this gene are unable to produce PABA. {ECO:0000269|PubMed 1644759}. # EcoGene EG11493 pabC # FUNCTION PABC_ECOLI Involved in the biosynthesis of p-aminobenzoate (PABA), a precursor of tetrahydrofolate. Converts 4-amino-4- deoxychorismate into 4-aminobenzoate (PABA) and pyruvate. {ECO 0000269|PubMed 1644759, ECO 0000269|PubMed 2251281}. # GO_function GO:0004084 branched-chain-amino-acid transaminase activity; IBA:GO_Central. # GO_function GO:0008696 4-amino-4-deoxychorismate lyase activity; IDA:UniProtKB. # GO_function GO:0030170 pyridoxal phosphate binding; IDA:EcoCyc. # GO_process GO:0006532 aspartate biosynthetic process; IBA:GO_Central. # GO_process GO:0009098 leucine biosynthetic process; IBA:GO_Central. # GO_process GO:0009099 valine biosynthetic process; IBA:GO_Central. # GO_process GO:0046654 tetrahydrofolate biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0046656 folic acid biosynthetic process; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # IntAct P28305 8 # InterPro IPR001544 Aminotrans_IV # InterPro IPR017824 Aminodeoxychorismate_lyase_IV # InterPro IPR018300 Aminotrans_IV_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00790 Folate biosynthesis # Organism PABC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11825 PTHR11825 # PATHWAY Cofactor biosynthesis; tetrahydrofolate biosynthesis; 4- aminobenzoate from chorismate step 2/2. # PATRIC 32117433 VBIEscCol129921_1139 # PDB 1ET0 X-ray; 2.20 A; A=1-269 # PDB 1I2K X-ray; 1.79 A; A=1-269 # PDB 1I2L X-ray; 2.30 A; A=1-269 # PIR A42954 A42954 # PROSITE PS00770 AA_TRANSFER_CLASS_4 # Pfam PF01063 Aminotran_4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PABC_ECOLI Aminodeoxychorismate lyase # RefSeq NP_415614 NC_000913.3 # RefSeq WP_000478681 NZ_LN832404.1 # SIMILARITY Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. {ECO 0000305}. # SUBUNIT PABC_ECOLI Homodimer. {ECO 0000269|PubMed 10876155, ECO 0000269|PubMed 11841211, ECO 0000269|PubMed 1644759, ECO 0000269|PubMed 2251281}. # SUPFAM SSF56752 SSF56752 # TIGRFAMs TIGR03461 pabC_Proteo # UniPathway UPA00077 UER00150 # eggNOG COG0115 LUCA # eggNOG ENOG4105YAZ Bacteria BLAST swissprot:PABC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PABC_ECOLI BioCyc ECOL316407:JW1082-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1082-MONOMER BioCyc EcoCyc:ADCLY-MONOMER http://biocyc.org/getid?id=EcoCyc:ADCLY-MONOMER BioCyc MetaCyc:ADCLY-MONOMER http://biocyc.org/getid?id=MetaCyc:ADCLY-MONOMER COG COG0115 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0115 DIP DIP-10435N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10435N DOI 10.1021/bi015791b http://dx.doi.org/10.1021/bi015791b DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.87.23.9391 http://dx.doi.org/10.1073/pnas.87.23.9391 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/oxfordjournals.jbchem.a022727 http://dx.doi.org/10.1093/oxfordjournals.jbchem.a022727 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.1.3.38 http://www.genome.jp/dbget-bin/www_bget?EC:4.1.3.38 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M93135 http://www.ebi.ac.uk/ena/data/view/M93135 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 4.1.3.38 http://enzyme.expasy.org/EC/4.1.3.38 EchoBASE EB1456 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1456 EcoGene EG11493 http://www.ecogene.org/geneInfo.php?eg_id=EG11493 EnsemblBacteria AAC74180 http://www.ensemblgenomes.org/id/AAC74180 EnsemblBacteria AAC74180 http://www.ensemblgenomes.org/id/AAC74180 EnsemblBacteria BAA35904 http://www.ensemblgenomes.org/id/BAA35904 EnsemblBacteria BAA35904 http://www.ensemblgenomes.org/id/BAA35904 EnsemblBacteria BAA35904 http://www.ensemblgenomes.org/id/BAA35904 EnsemblBacteria b1096 http://www.ensemblgenomes.org/id/b1096 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004084 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004084 GO_function GO:0008696 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008696 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_process GO:0006532 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006532 GO_process GO:0009098 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009098 GO_process GO:0009099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009099 GO_process GO:0046654 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046654 GO_process GO:0046656 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046656 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GeneID 946647 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946647 HOGENOM HOG000276707 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276707&db=HOGENOM6 InParanoid P28305 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P28305 IntAct P28305 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P28305* IntEnz 4.1.3.38 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.3.38 InterPro IPR001544 http://www.ebi.ac.uk/interpro/entry/IPR001544 InterPro IPR017824 http://www.ebi.ac.uk/interpro/entry/IPR017824 InterPro IPR018300 http://www.ebi.ac.uk/interpro/entry/IPR018300 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1082 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1082 KEGG_Gene eco:b1096 http://www.genome.jp/dbget-bin/www_bget?eco:b1096 KEGG_Orthology KO:K02619 http://www.genome.jp/dbget-bin/www_bget?KO:K02619 KEGG_Pathway ko00790 http://www.genome.jp/kegg-bin/show_pathway?ko00790 KEGG_Reaction rn:R05553 http://www.genome.jp/dbget-bin/www_bget?rn:R05553 OMA GALVECC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GALVECC PANTHER PTHR11825 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11825 PDB 1ET0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ET0 PDB 1I2K http://www.ebi.ac.uk/pdbe-srv/view/entry/1I2K PDB 1I2L http://www.ebi.ac.uk/pdbe-srv/view/entry/1I2L PDBsum 1ET0 http://www.ebi.ac.uk/pdbsum/1ET0 PDBsum 1I2K http://www.ebi.ac.uk/pdbsum/1I2K PDBsum 1I2L http://www.ebi.ac.uk/pdbsum/1I2L PROSITE PS00770 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00770 PSORT swissprot:PABC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PABC_ECOLI PSORT-B swissprot:PABC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PABC_ECOLI PSORT2 swissprot:PABC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PABC_ECOLI Pfam PF01063 http://pfam.xfam.org/family/PF01063 Phobius swissprot:PABC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PABC_ECOLI PhylomeDB P28305 http://phylomedb.org/?seqid=P28305 ProteinModelPortal P28305 http://www.proteinmodelportal.org/query/uniprot/P28305 PubMed 10876155 http://www.ncbi.nlm.nih.gov/pubmed/10876155 PubMed 11841211 http://www.ncbi.nlm.nih.gov/pubmed/11841211 PubMed 1644759 http://www.ncbi.nlm.nih.gov/pubmed/1644759 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2071583 http://www.ncbi.nlm.nih.gov/pubmed/2071583 PubMed 2251281 http://www.ncbi.nlm.nih.gov/pubmed/2251281 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415614 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415614 RefSeq WP_000478681 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000478681 SMR P28305 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P28305 STRING 511145.b1096 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1096&targetmode=cogs STRING COG0115 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0115&targetmode=cogs SUPFAM SSF56752 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56752 TIGRFAMs TIGR03461 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03461 UniProtKB PABC_ECOLI http://www.uniprot.org/uniprot/PABC_ECOLI UniProtKB-AC P28305 http://www.uniprot.org/uniprot/P28305 charge swissprot:PABC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PABC_ECOLI eggNOG COG0115 http://eggnogapi.embl.de/nog_data/html/tree/COG0115 eggNOG ENOG4105YAZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105YAZ epestfind swissprot:PABC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PABC_ECOLI garnier swissprot:PABC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PABC_ECOLI helixturnhelix swissprot:PABC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PABC_ECOLI hmoment swissprot:PABC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PABC_ECOLI iep swissprot:PABC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PABC_ECOLI inforesidue swissprot:PABC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PABC_ECOLI octanol swissprot:PABC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PABC_ECOLI pepcoil swissprot:PABC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PABC_ECOLI pepdigest swissprot:PABC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PABC_ECOLI pepinfo swissprot:PABC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PABC_ECOLI pepnet swissprot:PABC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PABC_ECOLI pepstats swissprot:PABC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PABC_ECOLI pepwheel swissprot:PABC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PABC_ECOLI pepwindow swissprot:PABC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PABC_ECOLI sigcleave swissprot:PABC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PABC_ECOLI ## Database ID URL or Descriptions # BioGrid 4263265 7 # EcoGene EG14078 yfaP # InterPro IPR012039 UCP012281 # InterPro IPR019220 DUF2135 # Organism YFAP_ECOLI Escherichia coli (strain K12) # PATRIC 32119809 VBIEscCol129921_2314 # PIR G64992 G64992 # PIRSF PIRSF012281 UCP012281 # Pfam PF09906 DUF2135 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFAP_ECOLI Uncharacterized protein YfaP # RefSeq NP_416729 NC_000913.3 # RefSeq WP_001225852 NZ_LN832404.1 # eggNOG COG4676 LUCA # eggNOG ENOG4105EDV Bacteria BLAST swissprot:YFAP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFAP_ECOLI BioCyc ECOL316407:JW2219-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2219-MONOMER BioCyc EcoCyc:G7152-MONOMER http://biocyc.org/getid?id=EcoCyc:G7152-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3831 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3831 EcoGene EG14078 http://www.ecogene.org/geneInfo.php?eg_id=EG14078 EnsemblBacteria AAC75285 http://www.ensemblgenomes.org/id/AAC75285 EnsemblBacteria AAC75285 http://www.ensemblgenomes.org/id/AAC75285 EnsemblBacteria BAE76669 http://www.ensemblgenomes.org/id/BAE76669 EnsemblBacteria BAE76669 http://www.ensemblgenomes.org/id/BAE76669 EnsemblBacteria BAE76669 http://www.ensemblgenomes.org/id/BAE76669 EnsemblBacteria b2225 http://www.ensemblgenomes.org/id/b2225 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946728 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946728 HOGENOM HOG000122323 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122323&db=HOGENOM6 InParanoid P76462 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76462 InterPro IPR012039 http://www.ebi.ac.uk/interpro/entry/IPR012039 InterPro IPR019220 http://www.ebi.ac.uk/interpro/entry/IPR019220 KEGG_Gene ecj:JW2219 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2219 KEGG_Gene eco:b2225 http://www.genome.jp/dbget-bin/www_bget?eco:b2225 OMA DVHYPAV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DVHYPAV PSORT swissprot:YFAP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFAP_ECOLI PSORT-B swissprot:YFAP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFAP_ECOLI PSORT2 swissprot:YFAP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFAP_ECOLI Pfam PF09906 http://pfam.xfam.org/family/PF09906 Phobius swissprot:YFAP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFAP_ECOLI PhylomeDB P76462 http://phylomedb.org/?seqid=P76462 ProteinModelPortal P76462 http://www.proteinmodelportal.org/query/uniprot/P76462 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416729 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416729 RefSeq WP_001225852 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001225852 SMR P76462 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76462 STRING 511145.b2225 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2225&targetmode=cogs UniProtKB YFAP_ECOLI http://www.uniprot.org/uniprot/YFAP_ECOLI UniProtKB-AC P76462 http://www.uniprot.org/uniprot/P76462 charge swissprot:YFAP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFAP_ECOLI eggNOG COG4676 http://eggnogapi.embl.de/nog_data/html/tree/COG4676 eggNOG ENOG4105EDV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EDV epestfind swissprot:YFAP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFAP_ECOLI garnier swissprot:YFAP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFAP_ECOLI helixturnhelix swissprot:YFAP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFAP_ECOLI hmoment swissprot:YFAP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFAP_ECOLI iep swissprot:YFAP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFAP_ECOLI inforesidue swissprot:YFAP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFAP_ECOLI octanol swissprot:YFAP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFAP_ECOLI pepcoil swissprot:YFAP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFAP_ECOLI pepdigest swissprot:YFAP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFAP_ECOLI pepinfo swissprot:YFAP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFAP_ECOLI pepnet swissprot:YFAP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFAP_ECOLI pepstats swissprot:YFAP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFAP_ECOLI pepwheel swissprot:YFAP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFAP_ECOLI pepwindow swissprot:YFAP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFAP_ECOLI sigcleave swissprot:YFAP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFAP_ECOLI ## Database ID URL or Descriptions # BioGrid 4262750 9 # EcoGene EG10314 fimG # FUNCTION FIMG_ECOLI Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Involved in the integration of FimH in the fimbriae. # GO_component GO:0009289 pilus; IEA:UniProtKB-SubCell. # GO_process GO:0007155 cell adhesion; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0007155 cell adhesion # Gene3D 2.60.40.1090 -; 1. # InterPro IPR000259 Adhesion_dom_fimbrial # InterPro IPR008966 Adhesion_dom # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Brite ko02044 Secretion system # Organism FIMG_ECOLI Escherichia coli (strain K12) # PATRIC 32124234 VBIEscCol129921_4460 # PDB 3BFQ X-ray; 1.34 A; G=36-167 # PDB 3BFW X-ray; 1.80 A; A/C=36-167 # PDB 3JWN X-ray; 2.69 A; G/M=24-167 # PDB 4J3O X-ray; 3.80 A; G=24-167 # PDB 4XO9 X-ray; 1.14 A; B=24-37 # PDB 4XOA X-ray; 2.54 A; B/D/F/H=24-37 # PDB 4XOD X-ray; 1.14 A; B=24-37 # PDB 5IQM X-ray; 1.50 A; A/G=36-167 # PDB 5IQN X-ray; 1.00 A; A/G=36-167 # PDB 5IQO X-ray; 1.30 A; A/C=36-167 # PIR S56544 S56544 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FIMG_ECOLI Protein FimG # RefSeq NP_418739 NC_000913.3 # RefSeq WP_000870592 NZ_LN832404.1 # SIMILARITY Belongs to the fimbrial protein family. {ECO 0000305}. # SUBCELLULAR LOCATION FIMG_ECOLI Fimbrium. # SUPFAM SSF49401 SSF49401 # eggNOG ENOG4108T65 Bacteria # eggNOG ENOG4111FMS LUCA BLAST swissprot:FIMG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FIMG_ECOLI BioCyc ECOL316407:JW4282-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4282-MONOMER BioCyc EcoCyc:EG10314-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10314-MONOMER COG COG3539 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3539 DIP DIP-9615N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9615N DOI 10.1007/BF00328136 http://dx.doi.org/10.1007/BF00328136 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X05672 http://www.ebi.ac.uk/ena/data/view/X05672 EchoBASE EB0310 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0310 EcoGene EG10314 http://www.ecogene.org/geneInfo.php?eg_id=EG10314 EnsemblBacteria AAC77275 http://www.ensemblgenomes.org/id/AAC77275 EnsemblBacteria AAC77275 http://www.ensemblgenomes.org/id/AAC77275 EnsemblBacteria BAE78312 http://www.ensemblgenomes.org/id/BAE78312 EnsemblBacteria BAE78312 http://www.ensemblgenomes.org/id/BAE78312 EnsemblBacteria BAE78312 http://www.ensemblgenomes.org/id/BAE78312 EnsemblBacteria b4319 http://www.ensemblgenomes.org/id/b4319 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009289 GO_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 Gene3D 2.60.40.1090 http://www.cathdb.info/version/latest/superfamily/2.60.40.1090 GeneID 948846 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948846 HOGENOM HOG000260127 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260127&db=HOGENOM6 InParanoid P08190 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P08190 IntAct P08190 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P08190* InterPro IPR000259 http://www.ebi.ac.uk/interpro/entry/IPR000259 InterPro IPR008966 http://www.ebi.ac.uk/interpro/entry/IPR008966 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW4282 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4282 KEGG_Gene eco:b4319 http://www.genome.jp/dbget-bin/www_bget?eco:b4319 KEGG_Orthology KO:K07349 http://www.genome.jp/dbget-bin/www_bget?KO:K07349 OMA FTHEAKF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FTHEAKF PDB 3BFQ http://www.ebi.ac.uk/pdbe-srv/view/entry/3BFQ PDB 3BFW http://www.ebi.ac.uk/pdbe-srv/view/entry/3BFW PDB 3JWN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JWN PDB 4J3O http://www.ebi.ac.uk/pdbe-srv/view/entry/4J3O PDB 4XO9 http://www.ebi.ac.uk/pdbe-srv/view/entry/4XO9 PDB 4XOA http://www.ebi.ac.uk/pdbe-srv/view/entry/4XOA PDB 4XOD http://www.ebi.ac.uk/pdbe-srv/view/entry/4XOD PDB 5IQM http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQM PDB 5IQN http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQN PDB 5IQO http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQO PDBsum 3BFQ http://www.ebi.ac.uk/pdbsum/3BFQ PDBsum 3BFW http://www.ebi.ac.uk/pdbsum/3BFW PDBsum 3JWN http://www.ebi.ac.uk/pdbsum/3JWN PDBsum 4J3O http://www.ebi.ac.uk/pdbsum/4J3O PDBsum 4XO9 http://www.ebi.ac.uk/pdbsum/4XO9 PDBsum 4XOA http://www.ebi.ac.uk/pdbsum/4XOA PDBsum 4XOD http://www.ebi.ac.uk/pdbsum/4XOD PDBsum 5IQM http://www.ebi.ac.uk/pdbsum/5IQM PDBsum 5IQN http://www.ebi.ac.uk/pdbsum/5IQN PDBsum 5IQO http://www.ebi.ac.uk/pdbsum/5IQO PSORT swissprot:FIMG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FIMG_ECOLI PSORT-B swissprot:FIMG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FIMG_ECOLI PSORT2 swissprot:FIMG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FIMG_ECOLI Phobius swissprot:FIMG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FIMG_ECOLI PhylomeDB P08190 http://phylomedb.org/?seqid=P08190 ProteinModelPortal P08190 http://www.proteinmodelportal.org/query/uniprot/P08190 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2890081 http://www.ncbi.nlm.nih.gov/pubmed/2890081 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418739 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418739 RefSeq WP_000870592 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000870592 SMR P08190 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P08190 STRING 511145.b4319 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4319&targetmode=cogs STRING COG3539 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3539&targetmode=cogs SUPFAM SSF49401 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49401 UniProtKB FIMG_ECOLI http://www.uniprot.org/uniprot/FIMG_ECOLI UniProtKB-AC P08190 http://www.uniprot.org/uniprot/P08190 charge swissprot:FIMG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FIMG_ECOLI eggNOG ENOG4108T65 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108T65 eggNOG ENOG4111FMS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111FMS epestfind swissprot:FIMG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FIMG_ECOLI garnier swissprot:FIMG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FIMG_ECOLI helixturnhelix swissprot:FIMG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FIMG_ECOLI hmoment swissprot:FIMG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FIMG_ECOLI iep swissprot:FIMG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FIMG_ECOLI inforesidue swissprot:FIMG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FIMG_ECOLI octanol swissprot:FIMG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FIMG_ECOLI pepcoil swissprot:FIMG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FIMG_ECOLI pepdigest swissprot:FIMG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FIMG_ECOLI pepinfo swissprot:FIMG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FIMG_ECOLI pepnet swissprot:FIMG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FIMG_ECOLI pepstats swissprot:FIMG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FIMG_ECOLI pepwheel swissprot:FIMG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FIMG_ECOLI pepwindow swissprot:FIMG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FIMG_ECOLI sigcleave swissprot:FIMG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FIMG_ECOLI ## Database ID URL or Descriptions # BioGrid 4260642 12 # CDD cd04458 CSP_CDS # EcoGene EG12179 cspE # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0001072 transcription antitermination factor activity, RNA binding; IDA:EcoliWiki. # GO_function GO:0003697 single-stranded DNA binding; IDA:EcoCyc. # GO_function GO:0003723 RNA binding; IDA:EcoliWiki. # GO_function GO:0008143 poly(A) binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0060567 negative regulation of DNA-templated transcription, termination; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0003723 RNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # IntAct P0A972 48 # InterPro IPR002059 CSP_DNA-bd # InterPro IPR011129 Cold_shock_prot # InterPro IPR012156 Cold_shock_CspA # InterPro IPR012340 NA-bd_OB-fold # InterPro IPR019844 Cold-shock_CS # KEGG_Brite ko03000 Transcription factors # MASS SPECTROMETRY Mass=7331; Method=Electrospray; Range=2-69; Evidence={ECO:0000269|PubMed 12071744}; # Organism CSPE_ECOLI Escherichia coli (strain K12) # PATRIC 32116426 VBIEscCol129921_0653 # PIR S49050 S49050 # PIRSF PIRSF002599 Cold_shock_A # PRINTS PR00050 COLDSHOCK # PROSITE PS00352 COLD_SHOCK # Pfam PF00313 CSD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CSPE_ECOLI Cold shock-like protein CspE # RefSeq NP_415156 NC_000913.3 # RefSeq WP_000034825 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40823.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Contains 1 CSD (cold-shock) domain. {ECO 0000305}. # SMART SM00357 CSP # SUBCELLULAR LOCATION CSPE_ECOLI Cytoplasm {ECO 0000250}. # SUPFAM SSF50249 SSF50249 # eggNOG COG1278 LUCA BLAST swissprot:CSPE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CSPE_ECOLI BioCyc ECOL316407:JW0618-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0618-MONOMER BioCyc EcoCyc:EG12179-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12179-MONOMER COG COG1278 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1278 DIP DIP-47834N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47834N DOI 10.1021/ja025966k http://dx.doi.org/10.1021/ja025966k DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1994.tb00359.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb00359.x DOI 10.1111/j.1365-2958.1994.tb00424.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb00424.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D28497 http://www.ebi.ac.uk/ena/data/view/D28497 EMBL L29054 http://www.ebi.ac.uk/ena/data/view/L29054 EMBL S83396 http://www.ebi.ac.uk/ena/data/view/S83396 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB2096 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2096 EcoGene EG12179 http://www.ecogene.org/geneInfo.php?eg_id=EG12179 EnsemblBacteria AAC73724 http://www.ensemblgenomes.org/id/AAC73724 EnsemblBacteria AAC73724 http://www.ensemblgenomes.org/id/AAC73724 EnsemblBacteria BAA35266 http://www.ensemblgenomes.org/id/BAA35266 EnsemblBacteria BAA35266 http://www.ensemblgenomes.org/id/BAA35266 EnsemblBacteria BAA35266 http://www.ensemblgenomes.org/id/BAA35266 EnsemblBacteria b0623 http://www.ensemblgenomes.org/id/b0623 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0001072 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001072 GO_function GO:0003697 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003697 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0008143 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008143 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0060567 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060567 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 23337261 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23337261 GeneID 947024 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947024 HOGENOM HOG000070674 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000070674&db=HOGENOM6 InParanoid P0A972 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A972 IntAct P0A972 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A972* InterPro IPR002059 http://www.ebi.ac.uk/interpro/entry/IPR002059 InterPro IPR011129 http://www.ebi.ac.uk/interpro/entry/IPR011129 InterPro IPR012156 http://www.ebi.ac.uk/interpro/entry/IPR012156 InterPro IPR012340 http://www.ebi.ac.uk/interpro/entry/IPR012340 InterPro IPR019844 http://www.ebi.ac.uk/interpro/entry/IPR019844 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW0618 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0618 KEGG_Gene eco:b0623 http://www.genome.jp/dbget-bin/www_bget?eco:b0623 KEGG_Orthology KO:K03704 http://www.genome.jp/dbget-bin/www_bget?KO:K03704 MINT MINT-1221433 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1221433 OMA HSEIQES http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HSEIQES PRINTS PR00050 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00050 PROSITE PS00352 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00352 PSORT swissprot:CSPE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CSPE_ECOLI PSORT-B swissprot:CSPE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CSPE_ECOLI PSORT2 swissprot:CSPE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CSPE_ECOLI Pfam PF00313 http://pfam.xfam.org/family/PF00313 Phobius swissprot:CSPE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CSPE_ECOLI PhylomeDB P0A972 http://phylomedb.org/?seqid=P0A972 ProteinModelPortal P0A972 http://www.proteinmodelportal.org/query/uniprot/P0A972 PubMed 12071744 http://www.ncbi.nlm.nih.gov/pubmed/12071744 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7984109 http://www.ncbi.nlm.nih.gov/pubmed/7984109 PubMed 8022259 http://www.ncbi.nlm.nih.gov/pubmed/8022259 PubMed 8844142 http://www.ncbi.nlm.nih.gov/pubmed/8844142 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415156 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415156 RefSeq WP_000034825 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000034825 SMART SM00357 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00357 SMR P0A972 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A972 STRING 511145.b0623 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0623&targetmode=cogs STRING COG1278 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1278&targetmode=cogs SUPFAM SSF50249 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50249 UniProtKB CSPE_ECOLI http://www.uniprot.org/uniprot/CSPE_ECOLI UniProtKB-AC P0A972 http://www.uniprot.org/uniprot/P0A972 charge swissprot:CSPE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CSPE_ECOLI eggNOG COG1278 http://eggnogapi.embl.de/nog_data/html/tree/COG1278 epestfind swissprot:CSPE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CSPE_ECOLI garnier swissprot:CSPE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CSPE_ECOLI helixturnhelix swissprot:CSPE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CSPE_ECOLI hmoment swissprot:CSPE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CSPE_ECOLI iep swissprot:CSPE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CSPE_ECOLI inforesidue swissprot:CSPE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CSPE_ECOLI octanol swissprot:CSPE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CSPE_ECOLI pepcoil swissprot:CSPE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CSPE_ECOLI pepdigest swissprot:CSPE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CSPE_ECOLI pepinfo swissprot:CSPE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CSPE_ECOLI pepnet swissprot:CSPE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CSPE_ECOLI pepstats swissprot:CSPE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CSPE_ECOLI pepwheel swissprot:CSPE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CSPE_ECOLI pepwindow swissprot:CSPE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CSPE_ECOLI sigcleave swissprot:CSPE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CSPE_ECOLI ## Database ID URL or Descriptions # BioGrid 4263309 280 # CATALYTIC ACTIVITY MANB_ECOLI Alpha-D-mannose 1-phosphate = D-mannose 6- phosphate. # COFACTOR MANB_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250}; Note=Binds 1 Mg(2+) ion per subunit. {ECO 0000250}; # EcoGene EG10162 manB # FUNCTION MANB_ECOLI Involved in the biosynthesis of the capsular polysaccharide colanic acid. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0000287 magnesium ion binding; IEA:InterPro. # GO_function GO:0004615 phosphomannomutase activity; IEA:UniProtKB-EC. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0009298 GDP-mannose biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.30.310.50 -; 1. # Gene3D 3.40.120.10 -; 3. # IntAct P24175 9 # InterPro IPR005841 Alpha-D-phosphohexomutase_SF # InterPro IPR005843 A-D-PHexomutase_C # InterPro IPR005844 A-D-PHexomutase_a/b/a-I # InterPro IPR005845 A-D-PHexomutase_a/b/a-II # InterPro IPR005846 A-D-PHexomutase_a/b/a-III # InterPro IPR016055 A-D-PHexomutase_a/b/a-I/II/III # InterPro IPR016066 A-D-PHexomutase_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00051 Fructose and mannose metabolism # KEGG_Pathway ko00520 Amino sugar and nucleotide sugar metabolism # Organism MANB_ECOLI Escherichia coli (strain K12) # PATHWAY Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6- phosphate step 2/2. # PATRIC 32119429 VBIEscCol129921_2125 # PIR B55239 B55239 # PRINTS PR00509 PGMPMM # PROSITE PS00710 PGM_PMM # Pfam PF00408 PGM_PMM_IV # Pfam PF02878 PGM_PMM_I # Pfam PF02879 PGM_PMM_II # Pfam PF02880 PGM_PMM_III # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MANB_ECOLI Phosphomannomutase # RefSeq NP_416552 NC_000913.3 # RefSeq WP_001350528 NZ_LN832404.1 # SIMILARITY Belongs to the phosphohexose mutase family. {ECO 0000305}. # SUPFAM SSF53738 SSF53738; 3 # SUPFAM SSF55957 SSF55957 # UniPathway UPA00126 UER00424 # eggNOG COG1109 LUCA # eggNOG ENOG4107QKV Bacteria BLAST swissprot:MANB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MANB_ECOLI BioCyc ECOL316407:JW2033-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2033-MONOMER BioCyc EcoCyc:PHOSMANMUT-MONOMER http://biocyc.org/getid?id=EcoCyc:PHOSMANMUT-MONOMER BioCyc MetaCyc:PHOSMANMUT-MONOMER http://biocyc.org/getid?id=MetaCyc:PHOSMANMUT-MONOMER COG COG1109 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1109 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.4.2.8 http://www.genome.jp/dbget-bin/www_bget?EC:5.4.2.8 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M77127 http://www.ebi.ac.uk/ena/data/view/M77127 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U38473 http://www.ebi.ac.uk/ena/data/view/U38473 ENZYME 5.4.2.8 http://enzyme.expasy.org/EC/5.4.2.8 EchoBASE EB0160 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0160 EcoGene EG10162 http://www.ecogene.org/geneInfo.php?eg_id=EG10162 EnsemblBacteria AAC75109 http://www.ensemblgenomes.org/id/AAC75109 EnsemblBacteria AAC75109 http://www.ensemblgenomes.org/id/AAC75109 EnsemblBacteria BAA15901 http://www.ensemblgenomes.org/id/BAA15901 EnsemblBacteria BAA15901 http://www.ensemblgenomes.org/id/BAA15901 EnsemblBacteria BAA15901 http://www.ensemblgenomes.org/id/BAA15901 EnsemblBacteria b2048 http://www.ensemblgenomes.org/id/b2048 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0004615 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004615 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GO_process GO:0009298 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009298 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.30.310.50 http://www.cathdb.info/version/latest/superfamily/3.30.310.50 Gene3D 3.40.120.10 http://www.cathdb.info/version/latest/superfamily/3.40.120.10 GeneID 946574 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946574 HOGENOM HOG000268679 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000268679&db=HOGENOM6 InParanoid P24175 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P24175 IntAct P24175 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P24175* IntEnz 5.4.2.8 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.4.2.8 InterPro IPR005841 http://www.ebi.ac.uk/interpro/entry/IPR005841 InterPro IPR005843 http://www.ebi.ac.uk/interpro/entry/IPR005843 InterPro IPR005844 http://www.ebi.ac.uk/interpro/entry/IPR005844 InterPro IPR005845 http://www.ebi.ac.uk/interpro/entry/IPR005845 InterPro IPR005846 http://www.ebi.ac.uk/interpro/entry/IPR005846 InterPro IPR016055 http://www.ebi.ac.uk/interpro/entry/IPR016055 InterPro IPR016066 http://www.ebi.ac.uk/interpro/entry/IPR016066 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2033 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2033 KEGG_Gene eco:b2048 http://www.genome.jp/dbget-bin/www_bget?eco:b2048 KEGG_Orthology KO:K01840 http://www.genome.jp/dbget-bin/www_bget?KO:K01840 KEGG_Pathway ko00051 http://www.genome.jp/kegg-bin/show_pathway?ko00051 KEGG_Pathway ko00520 http://www.genome.jp/kegg-bin/show_pathway?ko00520 KEGG_Reaction rn:R01818 http://www.genome.jp/dbget-bin/www_bget?rn:R01818 OMA NRQDTID http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NRQDTID PRINTS PR00509 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00509 PROSITE PS00710 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00710 PSORT swissprot:MANB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MANB_ECOLI PSORT-B swissprot:MANB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MANB_ECOLI PSORT2 swissprot:MANB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MANB_ECOLI Pfam PF00408 http://pfam.xfam.org/family/PF00408 Pfam PF02878 http://pfam.xfam.org/family/PF02878 Pfam PF02879 http://pfam.xfam.org/family/PF02879 Pfam PF02880 http://pfam.xfam.org/family/PF02880 Phobius swissprot:MANB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MANB_ECOLI PhylomeDB P24175 http://phylomedb.org/?seqid=P24175 ProteinModelPortal P24175 http://www.proteinmodelportal.org/query/uniprot/P24175 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7815923 http://www.ncbi.nlm.nih.gov/pubmed/7815923 PubMed 8759852 http://www.ncbi.nlm.nih.gov/pubmed/8759852 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416552 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416552 RefSeq WP_001350528 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001350528 SMR P24175 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P24175 STRING 511145.b2048 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2048&targetmode=cogs STRING COG1109 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1109&targetmode=cogs SUPFAM SSF53738 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53738 SUPFAM SSF55957 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55957 UniProtKB MANB_ECOLI http://www.uniprot.org/uniprot/MANB_ECOLI UniProtKB-AC P24175 http://www.uniprot.org/uniprot/P24175 charge swissprot:MANB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MANB_ECOLI eggNOG COG1109 http://eggnogapi.embl.de/nog_data/html/tree/COG1109 eggNOG ENOG4107QKV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QKV epestfind swissprot:MANB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MANB_ECOLI garnier swissprot:MANB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MANB_ECOLI helixturnhelix swissprot:MANB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MANB_ECOLI hmoment swissprot:MANB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MANB_ECOLI iep swissprot:MANB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MANB_ECOLI inforesidue swissprot:MANB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MANB_ECOLI octanol swissprot:MANB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MANB_ECOLI pepcoil swissprot:MANB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MANB_ECOLI pepdigest swissprot:MANB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MANB_ECOLI pepinfo swissprot:MANB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MANB_ECOLI pepnet swissprot:MANB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MANB_ECOLI pepstats swissprot:MANB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MANB_ECOLI pepwheel swissprot:MANB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MANB_ECOLI pepwindow swissprot:MANB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MANB_ECOLI sigcleave swissprot:MANB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MANB_ECOLI ## Database ID URL or Descriptions # AltName LUXS_ECOLI AI-2 synthesis protein # AltName LUXS_ECOLI Autoinducer-2 production protein LuxS # BRENDA 4.4.1.21 2026 # BioGrid 4263180 15 # CATALYTIC ACTIVITY LUXS_ECOLI S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L- homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione. # COFACTOR LUXS_ECOLI Name=Fe cation; Xref=ChEBI CHEBI 24875; Evidence={ECO 0000250}; Note=Binds 1 Fe cation per subunit. {ECO 0000250}; # EcoGene EG12712 luxS # FUNCTION LUXS_ECOLI Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD). {ECO 0000269|PubMed 9618536, ECO 0000269|PubMed 9990077}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0005506 iron ion binding; IEA:InterPro. # GO_function GO:0043768 S-ribosylhomocysteine lyase activity; IDA:EcoCyc. # GO_process GO:0010699 cell-cell signaling involved in quorum sensing; IMP:EcoCyc. # GO_process GO:0019284 L-methionine biosynthetic process from S-adenosylmethionine; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0007267 cell-cell signaling # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.30.1360.80 -; 1. # HAMAP MF_00091 LuxS # IntAct P45578 5 # InterPro IPR003815 S-ribosylhomocysteinase # InterPro IPR011249 Metalloenz_LuxS/M16 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00270 Cysteine and methionine metabolism # KEGG_Pathway ko05111 Vibrio cholerae pathogenic cycle # MISCELLANEOUS LUXS_ECOLI E.coli strain DH5-alpha does not make AI-2; it has a frameshift mutation in the luxS gene that disrupts the protein coding region. # Organism LUXS_ECOLI Escherichia coli (strain K12) # PATRIC 32120768 VBIEscCol129921_2781 # PIR H65048 H65048 # PIRSF PIRSF006160 AI2 # PRINTS PR01487 LUXSPROTEIN # Pfam PF02664 LuxS # ProDom PD013172 S-ribosylhomocysteinase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LUXS_ECOLI S-ribosylhomocysteine lyase # RefSeq NP_417172 NC_000913.3 # RefSeq WP_001130211 NZ_LN832404.1 # SIMILARITY Belongs to the LuxS family. {ECO 0000305}. # SUBUNIT Homodimer. {ECO 0000250}. # SUPFAM SSF63411 SSF63411 # eggNOG COG1854 LUCA # eggNOG ENOG4106762 Bacteria BLAST swissprot:LUXS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LUXS_ECOLI BioCyc ECOL316407:JW2662-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2662-MONOMER BioCyc EcoCyc:EG12712-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12712-MONOMER BioCyc MetaCyc:EG12712-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12712-MONOMER COG COG1854 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1854 DIP DIP-10131N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10131N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.89.19.8938 http://dx.doi.org/10.1073/pnas.89.19.8938 DOI 10.1073/pnas.95.12.7046 http://dx.doi.org/10.1073/pnas.95.12.7046 DOI 10.1073/pnas.96.4.1639 http://dx.doi.org/10.1073/pnas.96.4.1639 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.4.1.21 http://www.genome.jp/dbget-bin/www_bget?EC:4.4.1.21 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M86657 http://www.ebi.ac.uk/ena/data/view/M86657 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U83186 http://www.ebi.ac.uk/ena/data/view/U83186 ENZYME 4.4.1.21 http://enzyme.expasy.org/EC/4.4.1.21 EchoBASE EB2573 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2573 EcoGene EG12712 http://www.ecogene.org/geneInfo.php?eg_id=EG12712 EnsemblBacteria AAC75734 http://www.ensemblgenomes.org/id/AAC75734 EnsemblBacteria AAC75734 http://www.ensemblgenomes.org/id/AAC75734 EnsemblBacteria BAA16549 http://www.ensemblgenomes.org/id/BAA16549 EnsemblBacteria BAA16549 http://www.ensemblgenomes.org/id/BAA16549 EnsemblBacteria BAA16549 http://www.ensemblgenomes.org/id/BAA16549 EnsemblBacteria b2687 http://www.ensemblgenomes.org/id/b2687 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0043768 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043768 GO_process GO:0010699 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010699 GO_process GO:0019284 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019284 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0007267 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007267 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.30.1360.80 http://www.cathdb.info/version/latest/superfamily/3.30.1360.80 GeneID 947168 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947168 HAMAP MF_00091 http://hamap.expasy.org/unirule/MF_00091 HOGENOM HOG000040371 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000040371&db=HOGENOM6 InParanoid P45578 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45578 IntAct P45578 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45578* IntEnz 4.4.1.21 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.4.1.21 InterPro IPR003815 http://www.ebi.ac.uk/interpro/entry/IPR003815 InterPro IPR011249 http://www.ebi.ac.uk/interpro/entry/IPR011249 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2662 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2662 KEGG_Gene eco:b2687 http://www.genome.jp/dbget-bin/www_bget?eco:b2687 KEGG_Orthology KO:K07173 http://www.genome.jp/dbget-bin/www_bget?KO:K07173 KEGG_Pathway ko00270 http://www.genome.jp/kegg-bin/show_pathway?ko00270 KEGG_Pathway ko05111 http://www.genome.jp/kegg-bin/show_pathway?ko05111 KEGG_Reaction rn:R01291 http://www.genome.jp/dbget-bin/www_bget?rn:R01291 OMA AGFMREH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AGFMREH PRINTS PR01487 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01487 PSORT swissprot:LUXS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LUXS_ECOLI PSORT-B swissprot:LUXS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LUXS_ECOLI PSORT2 swissprot:LUXS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LUXS_ECOLI Pfam PF02664 http://pfam.xfam.org/family/PF02664 Phobius swissprot:LUXS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LUXS_ECOLI PhylomeDB P45578 http://phylomedb.org/?seqid=P45578 ProteinModelPortal P45578 http://www.proteinmodelportal.org/query/uniprot/P45578 PubMed 1409590 http://www.ncbi.nlm.nih.gov/pubmed/1409590 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9618536 http://www.ncbi.nlm.nih.gov/pubmed/9618536 PubMed 9990077 http://www.ncbi.nlm.nih.gov/pubmed/9990077 RefSeq NP_417172 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417172 RefSeq WP_001130211 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001130211 SMR P45578 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45578 STRING 511145.b2687 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2687&targetmode=cogs STRING COG1854 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1854&targetmode=cogs SUPFAM SSF63411 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63411 SWISS-2DPAGE P45578 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P45578 UniProtKB LUXS_ECOLI http://www.uniprot.org/uniprot/LUXS_ECOLI UniProtKB-AC P45578 http://www.uniprot.org/uniprot/P45578 charge swissprot:LUXS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LUXS_ECOLI eggNOG COG1854 http://eggnogapi.embl.de/nog_data/html/tree/COG1854 eggNOG ENOG4106762 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106762 epestfind swissprot:LUXS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LUXS_ECOLI garnier swissprot:LUXS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LUXS_ECOLI helixturnhelix swissprot:LUXS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LUXS_ECOLI hmoment swissprot:LUXS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LUXS_ECOLI iep swissprot:LUXS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LUXS_ECOLI inforesidue swissprot:LUXS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LUXS_ECOLI octanol swissprot:LUXS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LUXS_ECOLI pepcoil swissprot:LUXS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LUXS_ECOLI pepdigest swissprot:LUXS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LUXS_ECOLI pepinfo swissprot:LUXS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LUXS_ECOLI pepnet swissprot:LUXS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LUXS_ECOLI pepstats swissprot:LUXS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LUXS_ECOLI pepwheel swissprot:LUXS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LUXS_ECOLI pepwindow swissprot:LUXS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LUXS_ECOLI sigcleave swissprot:LUXS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LUXS_ECOLI ## Database ID URL or Descriptions # AltName Excinuclease ABC subunit A {ECO:0000255|HAMAP-Rule MF_00205} # BioGrid 4262670 26 # EcoGene EG11061 uvrA # FUNCTION UVRA_ECOLI The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. {ECO 0000255|HAMAP-Rule MF_00205}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0009380 excinuclease repair complex; IDA:UniProtKB. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008270 zinc ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0009381 excinuclease ABC activity; IEA:UniProtKB-HAMAP. # GO_function GO:0016887 ATPase activity; IDA:EcoCyc. # GO_process GO:0006281 DNA repair; IMP:EcoCyc. # GO_process GO:0006289 nucleotide-excision repair; IEA:UniProtKB-HAMAP. # GO_process GO:0009432 SOS response; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004518 nuclease activity # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # Gene3D 3.30.1490.20 -; 2. # Gene3D 3.40.50.300 -; 4. # HAMAP MF_00205 UvrA # INTERACTION UVRA_ECOLI P30958 mfd; NbExp=2; IntAct=EBI-552091, EBI-554211; # IntAct P0A698 14 # InterPro IPR003439 ABC_transporter-like # InterPro IPR004602 UvrA # InterPro IPR013815 ATP_grasp_subdomain_1 # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko03420 Nucleotide excision repair # MISCELLANEOUS UVRA_ECOLI Binds about 2 zinc atoms/molecule. # Organism UVRA_ECOLI Escherichia coli (strain K12) # PATRIC 32123661 VBIEscCol129921_4179 # PDB 4DFC X-ray; 2.80 A; B/D=131-250 # PIR A23869 BVECUA # PROSITE PS00211 ABC_TRANSPORTER_1; 2 # PROSITE PS50893 ABC_TRANSPORTER_2 # Pfam PF00005 ABC_tran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UvrABC system protein A {ECO:0000255|HAMAP-Rule MF_00205} # RefSeq NP_418482 NC_000913.3 # RefSeq WP_000357740 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. UvrA family. {ECO:0000255|HAMAP-Rule MF_00205}. # SIMILARITY Contains 2 ABC transporter domains. {ECO:0000255|HAMAP-Rule MF_00205}. # SUBCELLULAR LOCATION UVRA_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00205}. # SUBUNIT UVRA_ECOLI Forms a heterotetramer with UvrB during the search for lesions (By similarity). Interacts with TRCF (Mfd). UvrB and TRCF binding to UvrA could be mutually exclusive. {ECO 0000255|HAMAP- Rule MF_00205, ECO 0000269|PubMed 22331906}. # SUPFAM SSF52540 SSF52540; 3 # TIGRFAMs TIGR00630 uvra # eggNOG COG0178 LUCA # eggNOG ENOG4105C5U Bacteria BLAST swissprot:UVRA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UVRA_ECOLI BioCyc ECOL316407:JW4019-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4019-MONOMER BioCyc EcoCyc:EG11061-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11061-MONOMER BioCyc MetaCyc:EG11061-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11061-MONOMER COG COG0178 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0178 DIP DIP-35876N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35876N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1021/bi00230a005 http://dx.doi.org/10.1021/bi00230a005 DOI 10.1038/298096a0 http://dx.doi.org/10.1038/298096a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.1115105109 http://dx.doi.org/10.1073/pnas.1115105109 DOI 10.1093/nar/11.17.5795 http://dx.doi.org/10.1093/nar/11.17.5795 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01721 http://www.ebi.ac.uk/ena/data/view/J01721 EMBL M13495 http://www.ebi.ac.uk/ena/data/view/M13495 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X01621 http://www.ebi.ac.uk/ena/data/view/X01621 EchoBASE EB1054 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1054 EcoGene EG11061 http://www.ecogene.org/geneInfo.php?eg_id=EG11061 EnsemblBacteria AAC77028 http://www.ensemblgenomes.org/id/AAC77028 EnsemblBacteria AAC77028 http://www.ensemblgenomes.org/id/AAC77028 EnsemblBacteria BAE78060 http://www.ensemblgenomes.org/id/BAE78060 EnsemblBacteria BAE78060 http://www.ensemblgenomes.org/id/BAE78060 EnsemblBacteria BAE78060 http://www.ensemblgenomes.org/id/BAE78060 EnsemblBacteria b4058 http://www.ensemblgenomes.org/id/b4058 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0009380 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009380 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0009381 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009381 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_process GO:0006281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006281 GO_process GO:0006289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006289 GO_process GO:0009432 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009432 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.30.1490.20 http://www.cathdb.info/version/latest/superfamily/3.30.1490.20 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948559 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948559 HAMAP MF_00205 http://hamap.expasy.org/unirule/MF_00205 HOGENOM HOG000050448 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000050448&db=HOGENOM6 InParanoid P0A698 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A698 IntAct P0A698 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A698* InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR004602 http://www.ebi.ac.uk/interpro/entry/IPR004602 InterPro IPR013815 http://www.ebi.ac.uk/interpro/entry/IPR013815 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW4019 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4019 KEGG_Gene eco:b4058 http://www.genome.jp/dbget-bin/www_bget?eco:b4058 KEGG_Orthology KO:K03701 http://www.genome.jp/dbget-bin/www_bget?KO:K03701 KEGG_Pathway ko03420 http://www.genome.jp/kegg-bin/show_pathway?ko03420 MINT MINT-1257037 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1257037 OMA GAIKGWD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GAIKGWD PDB 4DFC http://www.ebi.ac.uk/pdbe-srv/view/entry/4DFC PDBsum 4DFC http://www.ebi.ac.uk/pdbsum/4DFC PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:UVRA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UVRA_ECOLI PSORT-B swissprot:UVRA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UVRA_ECOLI PSORT2 swissprot:UVRA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UVRA_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Phobius swissprot:UVRA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UVRA_ECOLI PhylomeDB P0A698 http://phylomedb.org/?seqid=P0A698 ProteinModelPortal P0A698 http://www.proteinmodelportal.org/query/uniprot/P0A698 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1826851 http://www.ncbi.nlm.nih.gov/pubmed/1826851 PubMed 22331906 http://www.ncbi.nlm.nih.gov/pubmed/22331906 PubMed 2550431 http://www.ncbi.nlm.nih.gov/pubmed/2550431 PubMed 3007478 http://www.ncbi.nlm.nih.gov/pubmed/3007478 PubMed 6283374 http://www.ncbi.nlm.nih.gov/pubmed/6283374 PubMed 6310514 http://www.ncbi.nlm.nih.gov/pubmed/6310514 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_418482 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418482 RefSeq WP_000357740 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000357740 SMR P0A698 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A698 STRING 511145.b4058 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4058&targetmode=cogs STRING COG0178 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0178&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR00630 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00630 UniProtKB UVRA_ECOLI http://www.uniprot.org/uniprot/UVRA_ECOLI UniProtKB-AC P0A698 http://www.uniprot.org/uniprot/P0A698 charge swissprot:UVRA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UVRA_ECOLI eggNOG COG0178 http://eggnogapi.embl.de/nog_data/html/tree/COG0178 eggNOG ENOG4105C5U http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C5U epestfind swissprot:UVRA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UVRA_ECOLI garnier swissprot:UVRA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UVRA_ECOLI helixturnhelix swissprot:UVRA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UVRA_ECOLI hmoment swissprot:UVRA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UVRA_ECOLI iep swissprot:UVRA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UVRA_ECOLI inforesidue swissprot:UVRA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UVRA_ECOLI octanol swissprot:UVRA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UVRA_ECOLI pepcoil swissprot:UVRA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UVRA_ECOLI pepdigest swissprot:UVRA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UVRA_ECOLI pepinfo swissprot:UVRA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UVRA_ECOLI pepnet swissprot:UVRA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UVRA_ECOLI pepstats swissprot:UVRA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UVRA_ECOLI pepwheel swissprot:UVRA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UVRA_ECOLI pepwindow swissprot:UVRA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UVRA_ECOLI sigcleave swissprot:UVRA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UVRA_ECOLI ## Database ID URL or Descriptions # AltName EIIBC-Tre {ECO:0000303|PubMed 2160944} # AltName PTS system trehalose-specific EIIB component {ECO:0000303|PubMed 2160944} # AltName PTS system trehalose-specific EIIB component {ECO:0000303|PubMed 2160944} # AltName PTS system trehalose-specific EIIC component {ECO:0000303|PubMed 2160944} # BIOPHYSICOCHEMICAL PROPERTIES PTTBC_ECOLI Kinetic parameters KM=16 uM for trehalose {ECO 0000269|PubMed 2160944}; Vmax=9 nmol/min/mg enzyme toward trehalose {ECO 0000269|PubMed 2160944}; # BioGrid 4262709 7 # CATALYTIC ACTIVITY [Protein]-N(pi)-phospho-L-histidine + alpha,alpha-trehalose(Side 1) = [protein]-L-histidine + alpha,alpha-trehalose 6-phosphate(Side 2). {ECO:0000269|PubMed 2160944}. # CDD cd00212 PTS_IIB_glc # DOMAIN PTTBC_ECOLI The EIIC domain type-1 forms the PTS system translocation channel and contains the specific substrate-binding site. {ECO 0000255|PROSITE-ProRule PRU00426}. # DOMAIN PTTBC_ECOLI The PTS EIIB type-1 domain is phosphorylated by phospho- EIIA-Glc (EIII-Glc) on a cysteinyl residue. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the PTS EIIC type-1 domain. {ECO 0000255|PROSITE-ProRule PRU00421, ECO 0000305|PubMed 2160944}. # EcoGene EG12127 treB # FUNCTION PTTBC_ECOLI The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in trehalose transport at low osmolarity. {ECO 0000269|PubMed 2160944, ECO 0000305|PubMed 7608078}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0008982 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:InterPro. # GO_function GO:0015574 trehalose transmembrane transporter activity; IEA:InterPro. # GO_function GO:0016301 kinase activity; IEA:UniProtKB-KW. # GO_function GO:0090589 protein-phosphocysteine-trehalose phosphotransferase system transporter activity; IDA:EcoCyc. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IDA:EcoCyc. # GO_process GO:0015771 trehalose transport; IDA:EcoCyc. # GO_process GO:0043610 regulation of carbohydrate utilization; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # Gene3D 3.30.1360.60 -; 1. # INDUCTION PTTBC_ECOLI At low osmolarity, treB is induced by trehalose-6- phosphate, but it becomes uninducible at high osmolarity due to induction of trehalose-6-phosphate phosphatase OstB which is part of the biosynthetic pathway of trehalose synthesis at high osmolarity. Repressed by TreR. {ECO 0000269|PubMed 2160944, ECO 0000269|PubMed 7608078}. # InterPro IPR001996 PTS_IIB_1 # InterPro IPR003352 PTS_EIIC # InterPro IPR004719 PTS_maltose/Glc_sub_IIC # InterPro IPR011296 PTS_IIBC_treh # InterPro IPR013013 PTS_EIIC_1 # InterPro IPR018113 PTrfase_EIIB_Cys # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00270 PTS system, trehalose-specific II component # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko00500 Starch and sucrose metabolism # KEGG_Pathway ko02060 Phosphotransferase system (PTS) # MISCELLANEOUS E.coli does not possess a trehalose-specific phosphotransferase enzyme IIA component, however it seems that it use the glucose-specific phosphotransferase enzyme IIA component to delivers trehalose-6-phosphate into the cell. {ECO:0000305|PubMed 2160944}. # Organism PTTBC_ECOLI Escherichia coli (strain K12) # PATRIC 32124055 VBIEscCol129921_4372 # PIR C65236 C65236 # PROSITE PS01035 PTS_EIIB_TYPE_1_CYS # PROSITE PS51098 PTS_EIIB_TYPE_1 # PROSITE PS51103 PTS_EIIC_TYPE_1 # Pfam PF00367 PTS_EIIB # Pfam PF02378 PTS_EIIC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PTS system trehalose-specific EIIBC component {ECO:0000303|PubMed 2160944} # RecName Trehalose permease IIC component {ECO:0000303|PubMed 2160944} # RecName Trehalose-specific phosphotransferase enzyme IIB component {ECO:0000303|PubMed 2160944} # RefSeq NP_418661 NC_000913.3 # SIMILARITY Contains 1 PTS EIIB type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00421}. # SIMILARITY Contains 1 PTS EIIC type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00426}. # SUBCELLULAR LOCATION PTTBC_ECOLI Cell inner membrane {ECO 0000255|PROSITE- ProRule PRU00426, ECO 0000305|PubMed 2160944}; Multi-pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00426}. # SUPFAM SSF55604 SSF55604 # TCDB 4.A.1.2 the pts glucose-glucoside (glc) family # TIGRFAMs TIGR00826 EIIB_glc # TIGRFAMs TIGR00852 pts-Glc # TIGRFAMs TIGR01992 PTS-IIBC-Tre # eggNOG COG1263 LUCA # eggNOG COG1264 LUCA # eggNOG ENOG4105C5Y Bacteria BLAST swissprot:PTTBC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTTBC_ECOLI BioCyc ECOL316407:JW4199-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4199-MONOMER BioCyc EcoCyc:TREB-MONOMER http://biocyc.org/getid?id=EcoCyc:TREB-MONOMER BioCyc MetaCyc:TREB-MONOMER http://biocyc.org/getid?id=MetaCyc:TREB-MONOMER COG COG1263 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1263 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.201 {ECO:0000269|PubMed:2160944} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.201 {ECO:0000269|PubMed:2160944} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U06195 http://www.ebi.ac.uk/ena/data/view/U06195 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 2.7.1.201 {ECO:0000269|PubMed:2160944} http://enzyme.expasy.org/EC/2.7.1.201 {ECO:0000269|PubMed:2160944} EchoBASE EB2048 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2048 EcoGene EG12127 http://www.ecogene.org/geneInfo.php?eg_id=EG12127 EnsemblBacteria AAC77197 http://www.ensemblgenomes.org/id/AAC77197 EnsemblBacteria AAC77197 http://www.ensemblgenomes.org/id/AAC77197 EnsemblBacteria BAE78239 http://www.ensemblgenomes.org/id/BAE78239 EnsemblBacteria BAE78239 http://www.ensemblgenomes.org/id/BAE78239 EnsemblBacteria BAE78239 http://www.ensemblgenomes.org/id/BAE78239 EnsemblBacteria b4240 http://www.ensemblgenomes.org/id/b4240 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008982 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008982 GO_function GO:0015574 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015574 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_function GO:0090589 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090589 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GO_process GO:0015771 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015771 GO_process GO:0043610 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043610 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.30.1360.60 http://www.cathdb.info/version/latest/superfamily/3.30.1360.60 GeneID 948761 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948761 HOGENOM HOG000102022 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000102022&db=HOGENOM6 InParanoid P36672 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P36672 IntAct P36672 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P36672* IntEnz 2.7.1.201 {ECO:0000269|PubMed:2160944} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.201 {ECO:0000269|PubMed:2160944} InterPro IPR001996 http://www.ebi.ac.uk/interpro/entry/IPR001996 InterPro IPR003352 http://www.ebi.ac.uk/interpro/entry/IPR003352 InterPro IPR004719 http://www.ebi.ac.uk/interpro/entry/IPR004719 InterPro IPR011296 http://www.ebi.ac.uk/interpro/entry/IPR011296 InterPro IPR013013 http://www.ebi.ac.uk/interpro/entry/IPR013013 InterPro IPR018113 http://www.ebi.ac.uk/interpro/entry/IPR018113 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW4199 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4199 KEGG_Gene eco:b4240 http://www.genome.jp/dbget-bin/www_bget?eco:b4240 KEGG_Orthology KO:K02819 http://www.genome.jp/dbget-bin/www_bget?KO:K02819 KEGG_Pathway ko00500 http://www.genome.jp/kegg-bin/show_pathway?ko00500 KEGG_Pathway ko02060 http://www.genome.jp/kegg-bin/show_pathway?ko02060 KEGG_Reaction rn:R02780 http://www.genome.jp/dbget-bin/www_bget?rn:R02780 MINT MINT-6478335 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-6478335 OMA VIGDIKM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VIGDIKM PROSITE PS01035 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01035 PROSITE PS51098 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51098 PROSITE PS51103 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51103 PSORT swissprot:PTTBC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTTBC_ECOLI PSORT-B swissprot:PTTBC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTTBC_ECOLI PSORT2 swissprot:PTTBC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTTBC_ECOLI Pfam PF00367 http://pfam.xfam.org/family/PF00367 Pfam PF02378 http://pfam.xfam.org/family/PF02378 Phobius swissprot:PTTBC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTTBC_ECOLI PhylomeDB P36672 http://phylomedb.org/?seqid=P36672 ProteinModelPortal P36672 http://www.proteinmodelportal.org/query/uniprot/P36672 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2160944 http://www.ncbi.nlm.nih.gov/pubmed/2160944 PubMed 7608078 http://www.ncbi.nlm.nih.gov/pubmed/7608078 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418661 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418661 SMR P36672 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P36672 STRING 511145.b4240 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4240&targetmode=cogs STRING COG1263 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1263&targetmode=cogs SUPFAM SSF55604 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55604 TCDB 4.A.1.2 http://www.tcdb.org/search/result.php?tc=4.A.1.2 TIGRFAMs TIGR00826 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00826 TIGRFAMs TIGR00852 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00852 TIGRFAMs TIGR01992 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01992 UniProtKB PTTBC_ECOLI http://www.uniprot.org/uniprot/PTTBC_ECOLI UniProtKB-AC P36672 http://www.uniprot.org/uniprot/P36672 charge swissprot:PTTBC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTTBC_ECOLI eggNOG COG1263 http://eggnogapi.embl.de/nog_data/html/tree/COG1263 eggNOG COG1264 http://eggnogapi.embl.de/nog_data/html/tree/COG1264 eggNOG ENOG4105C5Y http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C5Y epestfind swissprot:PTTBC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTTBC_ECOLI garnier swissprot:PTTBC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTTBC_ECOLI helixturnhelix swissprot:PTTBC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTTBC_ECOLI hmoment swissprot:PTTBC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTTBC_ECOLI iep swissprot:PTTBC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTTBC_ECOLI inforesidue swissprot:PTTBC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTTBC_ECOLI octanol swissprot:PTTBC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTTBC_ECOLI pepcoil swissprot:PTTBC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTTBC_ECOLI pepdigest swissprot:PTTBC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTTBC_ECOLI pepinfo swissprot:PTTBC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTTBC_ECOLI pepnet swissprot:PTTBC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTTBC_ECOLI pepstats swissprot:PTTBC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTTBC_ECOLI pepwheel swissprot:PTTBC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTTBC_ECOLI pepwindow swissprot:PTTBC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTTBC_ECOLI sigcleave swissprot:PTTBC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTTBC_ECOLI ## Database ID URL or Descriptions # AltName RFAB_ECOLI UDP-D-galactose--(Glucosyl)lipopolysaccharide-alpha-1,3-D-galactosyltransferase # BioGrid 4263407 258 # CAZy GT4 Glycosyltransferase Family 4 # EcoGene EG11351 rfaB # FUNCTION RFAB_ECOLI Adds a galactose goup to a glucose group of LPS. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008921 lipopolysaccharide-1,6-galactosyltransferase activity; IDA:EcoCyc. # GO_process GO:0009244 lipopolysaccharide core region biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # InterPro IPR001296 Glyco_trans_1 # InterPro IPR028098 Glyco_trans_4-like_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01003 Glycosyltransferases # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # KEGG_Pathway ko00540 Lipopolysaccharide biosynthesis # Organism RFAB_ECOLI Escherichia coli (strain K12) # PATHWAY RFAB_ECOLI Bacterial outer membrane biogenesis; LPS core biosynthesis. # PATRIC 32122743 VBIEscCol129921_3748 # PIR B42982 B42982 # Pfam PF00534 Glycos_transf_1 # Pfam PF13439 Glyco_transf_4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RFAB_ECOLI Lipopolysaccharide 1,6-galactosyltransferase # RefSeq NP_418085 NC_000913.3 # RefSeq WP_000683964 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA24085.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAB18605.1; Type=Erroneous initiation; Evidence={ECO 0000305}; Sequence=BAE77664.1; Type=Erroneous initiation; Evidence={ECO:0000305}; # SIMILARITY Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. {ECO 0000305}. # eggNOG COG0438 LUCA # eggNOG ENOG4107XU6 Bacteria BLAST swissprot:RFAB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RFAB_ECOLI BioCyc ECOL316407:JW3603-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3603-MONOMER BioCyc EcoCyc:EG11351-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11351-MONOMER BioCyc MetaCyc:EG11351-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11351-MONOMER COG COG0438 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0438 DIP DIP-10663N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10663N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.4.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.4.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M80599 http://www.ebi.ac.uk/ena/data/view/M80599 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.4.1.- http://enzyme.expasy.org/EC/2.4.1.- EchoBASE EB1326 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1326 EcoGene EG11351 http://www.ecogene.org/geneInfo.php?eg_id=EG11351 EnsemblBacteria AAC76652 http://www.ensemblgenomes.org/id/AAC76652 EnsemblBacteria AAC76652 http://www.ensemblgenomes.org/id/AAC76652 EnsemblBacteria BAE77664 http://www.ensemblgenomes.org/id/BAE77664 EnsemblBacteria BAE77664 http://www.ensemblgenomes.org/id/BAE77664 EnsemblBacteria BAE77664 http://www.ensemblgenomes.org/id/BAE77664 EnsemblBacteria b3628 http://www.ensemblgenomes.org/id/b3628 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008921 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008921 GO_process GO:0009244 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009244 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 948144 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948144 HOGENOM HOG000288854 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000288854&db=HOGENOM6 InParanoid P27127 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P27127 IntAct P27127 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P27127* IntEnz 2.4.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.1 InterPro IPR001296 http://www.ebi.ac.uk/interpro/entry/IPR001296 InterPro IPR028098 http://www.ebi.ac.uk/interpro/entry/IPR028098 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01003 http://www.genome.jp/dbget-bin/www_bget?ko01003 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Gene ecj:JW3603 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3603 KEGG_Gene eco:b3628 http://www.genome.jp/dbget-bin/www_bget?eco:b3628 KEGG_Orthology KO:K02840 http://www.genome.jp/dbget-bin/www_bget?KO:K02840 KEGG_Pathway ko00540 http://www.genome.jp/kegg-bin/show_pathway?ko00540 PSORT swissprot:RFAB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RFAB_ECOLI PSORT-B swissprot:RFAB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RFAB_ECOLI PSORT2 swissprot:RFAB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RFAB_ECOLI Pfam PF00534 http://pfam.xfam.org/family/PF00534 Pfam PF13439 http://pfam.xfam.org/family/PF13439 Phobius swissprot:RFAB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RFAB_ECOLI PhylomeDB P27127 http://phylomedb.org/?seqid=P27127 ProteinModelPortal P27127 http://www.proteinmodelportal.org/query/uniprot/P27127 PubMed 1624461 http://www.ncbi.nlm.nih.gov/pubmed/1624461 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418085 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418085 RefSeq WP_000683964 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000683964 STRING 511145.b3628 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3628&targetmode=cogs STRING COG0438 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0438&targetmode=cogs UniProtKB RFAB_ECOLI http://www.uniprot.org/uniprot/RFAB_ECOLI UniProtKB-AC P27127 http://www.uniprot.org/uniprot/P27127 charge swissprot:RFAB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RFAB_ECOLI eggNOG COG0438 http://eggnogapi.embl.de/nog_data/html/tree/COG0438 eggNOG ENOG4107XU6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107XU6 epestfind swissprot:RFAB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RFAB_ECOLI garnier swissprot:RFAB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RFAB_ECOLI helixturnhelix swissprot:RFAB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RFAB_ECOLI hmoment swissprot:RFAB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RFAB_ECOLI iep swissprot:RFAB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RFAB_ECOLI inforesidue swissprot:RFAB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RFAB_ECOLI octanol swissprot:RFAB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RFAB_ECOLI pepcoil swissprot:RFAB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RFAB_ECOLI pepdigest swissprot:RFAB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RFAB_ECOLI pepinfo swissprot:RFAB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RFAB_ECOLI pepnet swissprot:RFAB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RFAB_ECOLI pepstats swissprot:RFAB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RFAB_ECOLI pepwheel swissprot:RFAB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RFAB_ECOLI pepwindow swissprot:RFAB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RFAB_ECOLI sigcleave swissprot:RFAB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RFAB_ECOLI ## Database ID URL or Descriptions # AltName GSH1_ECOLI Gamma-ECS # AltName GSH1_ECOLI Gamma-glutamylcysteine synthetase # BRENDA 6.3.2 2026 # BioGrid 4262271 8 # CATALYTIC ACTIVITY GSH1_ECOLI ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine. # EcoGene EG10418 gshA # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004357 glutamate-cysteine ligase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0046872 metal ion binding; IDA:EcoCyc. # GO_process GO:0006750 glutathione biosynthetic process; IMP:EcoCyc. # GO_process GO:0006972 hyperosmotic response; IMP:EcoCyc. # GO_process GO:0071243 cellular response to arsenic-containing substance; IMP:EcoCyc. # GO_process GO:0071288 cellular response to mercury ion; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # HAMAP MF_00578 Glu_cys_ligase # IntAct P0A6W9 5 # InterPro IPR006334 Glut_cys_ligase # InterPro IPR007370 Glu_cys_ligase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00480 Glutathione metabolism # Organism GSH1_ECOLI Escherichia coli (strain K12) # PATHWAY Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate step 1/2. # PATRIC 32120770 VBIEscCol129921_2782 # PDB 1V4G X-ray; 2.50 A; A/B/C/D=1-518 # PDB 1VA6 X-ray; 2.10 A; A/B=1-518 # PDB 2D32 X-ray; 2.40 A; A/B/C/D=1-518 # PDB 2D33 X-ray; 2.60 A; A/B/C/D=1-518 # PIR A65049 SYECEC # Pfam PF04262 Glu_cys_ligase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GSH1_ECOLI Glutamate--cysteine ligase # RefSeq NP_417173 NC_000913.3 # RefSeq WP_000611804 NZ_LN832404.1 # SIMILARITY Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily. {ECO 0000305}. # TIGRFAMs TIGR01434 glu_cys_ligase # UniPathway UPA00142 UER00209 # eggNOG COG2918 LUCA # eggNOG ENOG4105D9M Bacteria BLAST swissprot:GSH1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GSH1_ECOLI BioCyc ECOL316407:JW2663-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2663-MONOMER BioCyc EcoCyc:GLUTCYSLIG-MONOMER http://biocyc.org/getid?id=EcoCyc:GLUTCYSLIG-MONOMER BioCyc MetaCyc:GLUTCYSLIG-MONOMER http://biocyc.org/getid?id=MetaCyc:GLUTCYSLIG-MONOMER COG COG2918 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2918 DIP DIP-48212N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48212N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/nar/14.11.4393 http://dx.doi.org/10.1093/nar/14.11.4393 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.3.2.2 http://www.genome.jp/dbget-bin/www_bget?EC:6.3.2.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X03954 http://www.ebi.ac.uk/ena/data/view/X03954 ENZYME 6.3.2.2 http://enzyme.expasy.org/EC/6.3.2.2 EchoBASE EB0413 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0413 EcoGene EG10418 http://www.ecogene.org/geneInfo.php?eg_id=EG10418 EnsemblBacteria AAC75735 http://www.ensemblgenomes.org/id/AAC75735 EnsemblBacteria AAC75735 http://www.ensemblgenomes.org/id/AAC75735 EnsemblBacteria BAA16555 http://www.ensemblgenomes.org/id/BAA16555 EnsemblBacteria BAA16555 http://www.ensemblgenomes.org/id/BAA16555 EnsemblBacteria BAA16555 http://www.ensemblgenomes.org/id/BAA16555 EnsemblBacteria b2688 http://www.ensemblgenomes.org/id/b2688 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004357 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004357 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006750 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006750 GO_process GO:0006972 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006972 GO_process GO:0071243 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071243 GO_process GO:0071288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071288 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 944881 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944881 HAMAP MF_00578 http://hamap.expasy.org/unirule/MF_00578 HOGENOM HOG000266224 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000266224&db=HOGENOM6 InParanoid P0A6W9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6W9 IntAct P0A6W9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6W9* IntEnz 6.3.2.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.2.2 InterPro IPR006334 http://www.ebi.ac.uk/interpro/entry/IPR006334 InterPro IPR007370 http://www.ebi.ac.uk/interpro/entry/IPR007370 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2663 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2663 KEGG_Gene eco:b2688 http://www.genome.jp/dbget-bin/www_bget?eco:b2688 KEGG_Orthology KO:K01919 http://www.genome.jp/dbget-bin/www_bget?KO:K01919 KEGG_Pathway ko00480 http://www.genome.jp/kegg-bin/show_pathway?ko00480 KEGG_Reaction rn:R00894 http://www.genome.jp/dbget-bin/www_bget?rn:R00894 OMA HRYGRRM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HRYGRRM PDB 1V4G http://www.ebi.ac.uk/pdbe-srv/view/entry/1V4G PDB 1VA6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1VA6 PDB 2D32 http://www.ebi.ac.uk/pdbe-srv/view/entry/2D32 PDB 2D33 http://www.ebi.ac.uk/pdbe-srv/view/entry/2D33 PDBsum 1V4G http://www.ebi.ac.uk/pdbsum/1V4G PDBsum 1VA6 http://www.ebi.ac.uk/pdbsum/1VA6 PDBsum 2D32 http://www.ebi.ac.uk/pdbsum/2D32 PDBsum 2D33 http://www.ebi.ac.uk/pdbsum/2D33 PSORT swissprot:GSH1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GSH1_ECOLI PSORT-B swissprot:GSH1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GSH1_ECOLI PSORT2 swissprot:GSH1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GSH1_ECOLI Pfam PF04262 http://pfam.xfam.org/family/PF04262 Phobius swissprot:GSH1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GSH1_ECOLI PhylomeDB P0A6W9 http://phylomedb.org/?seqid=P0A6W9 ProteinModelPortal P0A6W9 http://www.proteinmodelportal.org/query/uniprot/P0A6W9 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2872655 http://www.ncbi.nlm.nih.gov/pubmed/2872655 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417173 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417173 RefSeq WP_000611804 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000611804 SMR P0A6W9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6W9 STRING 511145.b2688 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2688&targetmode=cogs STRING COG2918 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2918&targetmode=cogs TIGRFAMs TIGR01434 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01434 UniProtKB GSH1_ECOLI http://www.uniprot.org/uniprot/GSH1_ECOLI UniProtKB-AC P0A6W9 http://www.uniprot.org/uniprot/P0A6W9 charge swissprot:GSH1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GSH1_ECOLI eggNOG COG2918 http://eggnogapi.embl.de/nog_data/html/tree/COG2918 eggNOG ENOG4105D9M http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D9M epestfind swissprot:GSH1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GSH1_ECOLI garnier swissprot:GSH1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GSH1_ECOLI helixturnhelix swissprot:GSH1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GSH1_ECOLI hmoment swissprot:GSH1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GSH1_ECOLI iep swissprot:GSH1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GSH1_ECOLI inforesidue swissprot:GSH1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GSH1_ECOLI octanol swissprot:GSH1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GSH1_ECOLI pepcoil swissprot:GSH1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GSH1_ECOLI pepdigest swissprot:GSH1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GSH1_ECOLI pepinfo swissprot:GSH1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GSH1_ECOLI pepnet swissprot:GSH1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GSH1_ECOLI pepstats swissprot:GSH1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GSH1_ECOLI pepwheel swissprot:GSH1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GSH1_ECOLI pepwindow swissprot:GSH1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GSH1_ECOLI sigcleave swissprot:GSH1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GSH1_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES ALSK_ECOLI Kinetic parameters KM=0.19 mM for D-allose (at 25 degrees Celsius and pH 7.6) {ECO 0000269|PubMed 17979299}; KM=0.27 mM for ATP (at 25 degrees Celsius and pH 7.6) {ECO 0000269|PubMed 17979299}; KM=29 mM for D-glucose (at 25 degrees Celsius and pH 7.6) {ECO 0000269|PubMed 17979299}; KM=210 mM for D-altrose (at 25 degrees Celsius and pH 7.6) {ECO 0000269|PubMed 17979299}; KM=380 mM for 2'-deoxy-D-glucose (at 25 degrees Celsius and pH 7.6) {ECO 0000269|PubMed 17979299}; KM=390 mM for D-mannose (at 25 degrees Celsius and pH 7.6) {ECO 0000269|PubMed 17979299}; Note=Catalytic efficiency with D-allose as substrate is 735-fold higher than that with D-glucose.; # BioGrid 4262956 15 # CATALYTIC ACTIVITY ALSK_ECOLI ATP + D-allose = ADP + D-allose 6-phosphate. {ECO 0000255|HAMAP-Rule MF_00988, ECO 0000269|PubMed 17979299}. # EcoGene EG11956 alsK # FUNCTION ALSK_ECOLI Catalyzes the phosphorylation of D-allose to D-allose 6- phosphate. Has also low level glucokinase activity in vitro. {ECO 0000255|HAMAP-Rule MF_00988, ECO 0000269|PubMed 17979299, ECO 0000269|PubMed 9401019}. # GO_function GO:0004340 glucokinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008787 allose kinase activity; IDA:EcoCyc. # GO_process GO:0019316 D-allose catabolic process; IDA:EcoCyc. # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # HAMAP MF_00988 Allose_kinase # IntAct P32718 2 # InterPro IPR000600 ROK # InterPro IPR030883 AlsK # KEGG_Brite ko01000 Enzymes # Organism ALSK_ECOLI Escherichia coli (strain K12) # PATHWAY Carbohydrate degradation; D-allose degradation. {ECO:0000255|HAMAP-Rule MF_00988}. # PATRIC 32123723 VBIEscCol129921_4210 # PDB 3HTV X-ray; 1.95 A; A=1-309 # PIR C65217 C65217 # PROSITE PS01125 ROK # Pfam PF00480 ROK # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName D-allose kinase {ECO:0000255|HAMAP-Rule MF_00988} # RefSeq NP_418508 NC_000913.3 # RefSeq WP_001171687 NZ_CP014272.1 # SIMILARITY Belongs to the ROK (NagC/XylR) family. {ECO:0000255|HAMAP-Rule MF_00988}. # eggNOG COG1940 LUCA # eggNOG ENOG4107TFG Bacteria BLAST swissprot:ALSK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ALSK_ECOLI BioCyc ECOL316407:JW5724-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5724-MONOMER BioCyc EcoCyc:EG11956-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11956-MONOMER BioCyc MetaCyc:EG11956-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11956-MONOMER DIP DIP-9097N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9097N DOI 10.1021/bi700924d http://dx.doi.org/10.1021/bi700924d DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.55 {ECO:0000255|HAMAP-Rule:MF_00988} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.55 {ECO:0000255|HAMAP-Rule:MF_00988} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.55 {ECO:0000255|HAMAP-Rule:MF_00988} http://enzyme.expasy.org/EC/2.7.1.55 {ECO:0000255|HAMAP-Rule:MF_00988} EchoBASE EB1899 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1899 EcoGene EG11956 http://www.ecogene.org/geneInfo.php?eg_id=EG11956 EnsemblBacteria AAC77045 http://www.ensemblgenomes.org/id/AAC77045 EnsemblBacteria AAC77045 http://www.ensemblgenomes.org/id/AAC77045 EnsemblBacteria BAE78087 http://www.ensemblgenomes.org/id/BAE78087 EnsemblBacteria BAE78087 http://www.ensemblgenomes.org/id/BAE78087 EnsemblBacteria BAE78087 http://www.ensemblgenomes.org/id/BAE78087 EnsemblBacteria b4084 http://www.ensemblgenomes.org/id/b4084 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004340 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004340 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008787 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008787 GO_process GO:0019316 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019316 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 948596 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948596 HAMAP MF_00988 http://hamap.expasy.org/unirule/MF_00988 HOGENOM HOG000126964 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126964&db=HOGENOM6 InParanoid P32718 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32718 IntAct P32718 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32718* IntEnz 2.7.1.55 {ECO:0000255|HAMAP-Rule:MF_00988} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.55 {ECO:0000255|HAMAP-Rule:MF_00988} InterPro IPR000600 http://www.ebi.ac.uk/interpro/entry/IPR000600 InterPro IPR030883 http://www.ebi.ac.uk/interpro/entry/IPR030883 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5724 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5724 KEGG_Gene eco:b4084 http://www.genome.jp/dbget-bin/www_bget?eco:b4084 KEGG_Orthology KO:K00881 http://www.genome.jp/dbget-bin/www_bget?KO:K00881 OMA TGCRGAC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TGCRGAC PDB 3HTV http://www.ebi.ac.uk/pdbe-srv/view/entry/3HTV PDBsum 3HTV http://www.ebi.ac.uk/pdbsum/3HTV PROSITE PS01125 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01125 PSORT swissprot:ALSK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ALSK_ECOLI PSORT-B swissprot:ALSK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ALSK_ECOLI PSORT2 swissprot:ALSK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ALSK_ECOLI Pfam PF00480 http://pfam.xfam.org/family/PF00480 Phobius swissprot:ALSK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ALSK_ECOLI PhylomeDB P32718 http://phylomedb.org/?seqid=P32718 ProteinModelPortal P32718 http://www.proteinmodelportal.org/query/uniprot/P32718 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17979299 http://www.ncbi.nlm.nih.gov/pubmed/17979299 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9401019 http://www.ncbi.nlm.nih.gov/pubmed/9401019 RefSeq NP_418508 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418508 RefSeq WP_001171687 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001171687 SMR P32718 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32718 STRING 511145.b4084 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4084&targetmode=cogs UniProtKB ALSK_ECOLI http://www.uniprot.org/uniprot/ALSK_ECOLI UniProtKB-AC P32718 http://www.uniprot.org/uniprot/P32718 charge swissprot:ALSK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ALSK_ECOLI eggNOG COG1940 http://eggnogapi.embl.de/nog_data/html/tree/COG1940 eggNOG ENOG4107TFG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107TFG epestfind swissprot:ALSK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ALSK_ECOLI garnier swissprot:ALSK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ALSK_ECOLI helixturnhelix swissprot:ALSK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ALSK_ECOLI hmoment swissprot:ALSK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ALSK_ECOLI iep swissprot:ALSK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ALSK_ECOLI inforesidue swissprot:ALSK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ALSK_ECOLI octanol swissprot:ALSK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ALSK_ECOLI pepcoil swissprot:ALSK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ALSK_ECOLI pepdigest swissprot:ALSK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ALSK_ECOLI pepinfo swissprot:ALSK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ALSK_ECOLI pepnet swissprot:ALSK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ALSK_ECOLI pepstats swissprot:ALSK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ALSK_ECOLI pepwheel swissprot:ALSK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ALSK_ECOLI pepwindow swissprot:ALSK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ALSK_ECOLI sigcleave swissprot:ALSK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ALSK_ECOLI ## Database ID URL or Descriptions # AltName STPA_ECOLI H-NS homolog StpA # BioGrid 4262261 7 # DISRUPTION PHENOTYPE STPA_ECOLI No visible phenotype in rich medium; double hns-stpA mutants grow slower and have reduced viable cell counts compared to single hns mutants in MC1029 and MC4100 backgrounds (PubMed 8890170). In 0.3M NaCl a double hns-stpA deletion up- regulates 583 and down-regulates 86 genes, 363 of which are thought to have been horizontally acquired; 131 are also up- regulated in a double cnu-hha deletion (PubMed 23543115). {ECO 0000269|PubMed 23543115, ECO 0000269|PubMed 8890170}. # DOMAIN STPA_ECOLI Both the N-terminus (residues 1-76) and the C-terminus (residues 90-134) have RNA chaperone activity for splicing of td, a bacteriophage T4 pre-mRNA (PubMed 17267410). {ECO 0000269|PubMed 17267410}. # EcoGene EG11554 stpA # FUNCTION STPA_ECOLI (Microbial infection) Originally isolated as a suppressor of a splicing defect of the thymidylate synthase (td) gene from bacteriophage T4 (PubMed 1480493). Acts as an RNA chaperone, accelerating splicing of viral pre-mRNA. Binds preferentially to unstructured over structured RNA; does not have a detectable high-affinity RNA-binding site in the pre-mRNA. There do not seem to be any specific RNA targets in transcribed E.coli DNA (PubMed 17267410). {ECO 0000269|PubMed 1480493, ECO 0000269|PubMed 17267410}. # FUNCTION STPA_ECOLI A DNA-binding protein that acts in a fashion similar to H-NS protein upon overexpression, represses a number of genes including the cryptic blg operon, hns, papB and the proU locus (PubMed 8890170). A subset of H-NS/StpA-regulated genes also require Hha for repression; Hha and Cnu (YdgT) increases the number of genes DNA bound by H-NS/StpA and may also modulate the oligomerization of the H-NS/StpA-complex (PubMed 23543115). Repression can be inhibited by dominant-negative mutants of StpA or H-NS (PubMed 8755860). {ECO 0000269|PubMed 23543115, ECO 0000269|PubMed 8755860, ECO 0000269|PubMed 8890170}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0009295 nucleoid; IEA:UniProtKB-SubCell. # GO_function GO:0003677 DNA binding; IDA:EcoliWiki. # GO_function GO:0003723 RNA binding; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0003723 RNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.287.1050 -; 1. # Gene3D 4.10.430.10 -; 1. # INDUCTION Expressed at low levels at 37 degrees Celsius, barely detectable at 26 degrees Celsius; expression is repressed by hns and partially activated by lrp (PubMed:8890170). {ECO 0000269|PubMed:8890170}. # INTERACTION STPA_ECOLI P0ACF8 hns; NbExp=3; IntAct=EBI-551928, EBI-544934; # IntAct P0ACG1 23 # InterPro IPR001801 Histone_HNS # InterPro IPR027444 H-NS_C_dom # InterPro IPR027454 Histone_HNS_oligo_dom # KEGG_Brite ko03036 Chromosome # Organism STPA_ECOLI Escherichia coli (strain K12) # PATRIC 32120728 VBIEscCol129921_2761 # PDB 2LRX NMR; -; A=90-134 # PIR JH0774 JH0774 # PIRSF PIRSF002096 HnS # Pfam PF00816 Histone_HNS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName STPA_ECOLI DNA-binding protein StpA # RefSeq NP_417155 NC_000913.3 # RefSeq WP_000115383 NZ_LN832404.1 # SIMILARITY Belongs to the histone-like protein H-NS family. {ECO 0000305}. # SMART SM00528 HNS # SUBCELLULAR LOCATION STPA_ECOLI Cytoplasm, nucleoid {ECO 0000269|PubMed 21903814}. Note=Scattered throughout the nucleoid (PubMed 21903814). {ECO 0000269|PubMed 21903814}. # SUBUNIT STPA_ECOLI When overexpressed forms homodimers, can interact with the N-terminus (residues 1-64) of H-NS (PubMed 8755860). May interact with Hha and/or Cnu. {ECO 0000269|PubMed 8755860, ECO 0000305}. # eggNOG COG2916 LUCA # eggNOG ENOG4108X73 Bacteria BLAST swissprot:STPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:STPA_ECOLI BioCyc ECOL316407:JW2644-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2644-MONOMER BioCyc EcoCyc:EG11554-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11554-MONOMER COG COG2916 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2916 DIP DIP-35951N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35951N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/dnares/dst008 http://dx.doi.org/10.1093/dnares/dst008 DOI 10.1093/nar/20.24.6735 http://dx.doi.org/10.1093/nar/20.24.6735 DOI 10.1093/nar/gkl1143 http://dx.doi.org/10.1093/nar/gkl1143 DOI 10.1126/science.1204697 http://dx.doi.org/10.1126/science.1204697 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U07823 http://www.ebi.ac.uk/ena/data/view/U07823 EMBL X69210 http://www.ebi.ac.uk/ena/data/view/X69210 EchoBASE EB1515 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1515 EcoGene EG11554 http://www.ecogene.org/geneInfo.php?eg_id=EG11554 EnsemblBacteria AAC75716 http://www.ensemblgenomes.org/id/AAC75716 EnsemblBacteria AAC75716 http://www.ensemblgenomes.org/id/AAC75716 EnsemblBacteria BAA16535 http://www.ensemblgenomes.org/id/BAA16535 EnsemblBacteria BAA16535 http://www.ensemblgenomes.org/id/BAA16535 EnsemblBacteria BAA16535 http://www.ensemblgenomes.org/id/BAA16535 EnsemblBacteria b2669 http://www.ensemblgenomes.org/id/b2669 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0009295 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009295 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.287.1050 http://www.cathdb.info/version/latest/superfamily/1.10.287.1050 Gene3D 4.10.430.10 http://www.cathdb.info/version/latest/superfamily/4.10.430.10 GeneID 947130 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947130 HOGENOM HOG000218473 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218473&db=HOGENOM6 IntAct P0ACG1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACG1* InterPro IPR001801 http://www.ebi.ac.uk/interpro/entry/IPR001801 InterPro IPR027444 http://www.ebi.ac.uk/interpro/entry/IPR027444 InterPro IPR027454 http://www.ebi.ac.uk/interpro/entry/IPR027454 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene ecj:JW2644 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2644 KEGG_Gene eco:b2669 http://www.genome.jp/dbget-bin/www_bget?eco:b2669 KEGG_Orthology KO:K11685 http://www.genome.jp/dbget-bin/www_bget?KO:K11685 MINT MINT-1247857 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1247857 OMA VNTWLEL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VNTWLEL PDB 2LRX http://www.ebi.ac.uk/pdbe-srv/view/entry/2LRX PDBsum 2LRX http://www.ebi.ac.uk/pdbsum/2LRX PSORT swissprot:STPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:STPA_ECOLI PSORT-B swissprot:STPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:STPA_ECOLI PSORT2 swissprot:STPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:STPA_ECOLI Pfam PF00816 http://pfam.xfam.org/family/PF00816 Phobius swissprot:STPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:STPA_ECOLI ProteinModelPortal P0ACG1 http://www.proteinmodelportal.org/query/uniprot/P0ACG1 PubMed 1480493 http://www.ncbi.nlm.nih.gov/pubmed/1480493 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17267410 http://www.ncbi.nlm.nih.gov/pubmed/17267410 PubMed 21903814 http://www.ncbi.nlm.nih.gov/pubmed/21903814 PubMed 23543115 http://www.ncbi.nlm.nih.gov/pubmed/23543115 PubMed 7961433 http://www.ncbi.nlm.nih.gov/pubmed/7961433 PubMed 8755860 http://www.ncbi.nlm.nih.gov/pubmed/8755860 PubMed 8890170 http://www.ncbi.nlm.nih.gov/pubmed/8890170 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417155 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417155 RefSeq WP_000115383 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000115383 SMART SM00528 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00528 SMR P0ACG1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACG1 STRING 511145.b2669 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2669&targetmode=cogs STRING COG2916 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2916&targetmode=cogs UniProtKB STPA_ECOLI http://www.uniprot.org/uniprot/STPA_ECOLI UniProtKB-AC P0ACG1 http://www.uniprot.org/uniprot/P0ACG1 charge swissprot:STPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:STPA_ECOLI eggNOG COG2916 http://eggnogapi.embl.de/nog_data/html/tree/COG2916 eggNOG ENOG4108X73 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108X73 epestfind swissprot:STPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:STPA_ECOLI garnier swissprot:STPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:STPA_ECOLI helixturnhelix swissprot:STPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:STPA_ECOLI hmoment swissprot:STPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:STPA_ECOLI iep swissprot:STPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:STPA_ECOLI inforesidue swissprot:STPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:STPA_ECOLI octanol swissprot:STPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:STPA_ECOLI pepcoil swissprot:STPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:STPA_ECOLI pepdigest swissprot:STPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:STPA_ECOLI pepinfo swissprot:STPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:STPA_ECOLI pepnet swissprot:STPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:STPA_ECOLI pepstats swissprot:STPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:STPA_ECOLI pepwheel swissprot:STPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:STPA_ECOLI pepwindow swissprot:STPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:STPA_ECOLI sigcleave swissprot:STPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:STPA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261058 169 # EcoGene EG11660 yedE # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR007272 Sulf_transp # Organism YEDE_ECOLI Escherichia coli (strain K12) # PATRIC 32119193 VBIEscCol129921_2011 # PIR F64956 F64956 # Pfam PF04143 Sulf_transp; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEDE_ECOLI UPF0394 inner membrane protein YedE # RefSeq NP_416439 NC_000913.3 # RefSeq WP_000118897 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0394 family. {ECO 0000305}. # SUBCELLULAR LOCATION YEDE_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 9.B.102.1 the yede/yeee (yede/yeee) family # eggNOG COG2391 LUCA # eggNOG ENOG41066VF Bacteria BLAST swissprot:YEDE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEDE_ECOLI BioCyc ECOL316407:JW1914-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1914-MONOMER BioCyc EcoCyc:EG11660-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11660-MONOMER COG COG2391 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2391 DIP DIP-11839N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11839N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1099/00221287-139-7-1401 http://dx.doi.org/10.1099/00221287-139-7-1401 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L13279 http://www.ebi.ac.uk/ena/data/view/L13279 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1612 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1612 EcoGene EG11660 http://www.ecogene.org/geneInfo.php?eg_id=EG11660 EnsemblBacteria AAC74996 http://www.ensemblgenomes.org/id/AAC74996 EnsemblBacteria AAC74996 http://www.ensemblgenomes.org/id/AAC74996 EnsemblBacteria BAA15757 http://www.ensemblgenomes.org/id/BAA15757 EnsemblBacteria BAA15757 http://www.ensemblgenomes.org/id/BAA15757 EnsemblBacteria BAA15757 http://www.ensemblgenomes.org/id/BAA15757 EnsemblBacteria b1929 http://www.ensemblgenomes.org/id/b1929 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 945192 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945192 HOGENOM HOG000285397 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000285397&db=HOGENOM6 InParanoid P31064 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31064 IntAct P31064 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31064* InterPro IPR007272 http://www.ebi.ac.uk/interpro/entry/IPR007272 KEGG_Gene ecj:JW1914 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1914 KEGG_Gene eco:b1929 http://www.genome.jp/dbget-bin/www_bget?eco:b1929 KEGG_Orthology KO:K07112 http://www.genome.jp/dbget-bin/www_bget?KO:K07112 MINT MINT-1246874 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1246874 OMA VMIIGMF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VMIIGMF PSORT swissprot:YEDE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEDE_ECOLI PSORT-B swissprot:YEDE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEDE_ECOLI PSORT2 swissprot:YEDE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEDE_ECOLI Pfam PF04143 http://pfam.xfam.org/family/PF04143 Phobius swissprot:YEDE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEDE_ECOLI ProteinModelPortal P31064 http://www.proteinmodelportal.org/query/uniprot/P31064 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8371104 http://www.ncbi.nlm.nih.gov/pubmed/8371104 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416439 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416439 RefSeq WP_000118897 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000118897 SMR P31064 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31064 STRING 511145.b1929 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1929&targetmode=cogs STRING COG2391 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2391&targetmode=cogs TCDB 9.B.102.1 http://www.tcdb.org/search/result.php?tc=9.B.102.1 UniProtKB YEDE_ECOLI http://www.uniprot.org/uniprot/YEDE_ECOLI UniProtKB-AC P31064 http://www.uniprot.org/uniprot/P31064 charge swissprot:YEDE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEDE_ECOLI eggNOG COG2391 http://eggnogapi.embl.de/nog_data/html/tree/COG2391 eggNOG ENOG41066VF http://eggnogapi.embl.de/nog_data/html/tree/ENOG41066VF epestfind swissprot:YEDE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEDE_ECOLI garnier swissprot:YEDE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEDE_ECOLI helixturnhelix swissprot:YEDE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEDE_ECOLI hmoment swissprot:YEDE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEDE_ECOLI iep swissprot:YEDE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEDE_ECOLI inforesidue swissprot:YEDE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEDE_ECOLI octanol swissprot:YEDE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEDE_ECOLI pepcoil swissprot:YEDE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEDE_ECOLI pepdigest swissprot:YEDE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEDE_ECOLI pepinfo swissprot:YEDE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEDE_ECOLI pepnet swissprot:YEDE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEDE_ECOLI pepstats swissprot:YEDE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEDE_ECOLI pepwheel swissprot:YEDE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEDE_ECOLI pepwindow swissprot:YEDE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEDE_ECOLI sigcleave swissprot:YEDE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEDE_ECOLI ## Database ID URL or Descriptions # AltName (2R,3S)-2-methylisocitrate lyase {ECO:0000303|PubMed 11422389} # BIOPHYSICOCHEMICAL PROPERTIES PRPB_ECOLI Kinetic parameters KM=35 uM for magnesium {ECO 0000269|PubMed 11422389, ECO 0000269|PubMed 15723538}; KM=19 uM for threo-2-methylisocitrate (a mixture of (2R,3S)- and (2S,3R)-2-methylisocitrate in presence of 2 mM magnesium at pH 7 and 30 degrees Celsius) {ECO 0000269|PubMed 11422389, ECO 0000269|PubMed 15723538}; Note=Kcat is 12 sec(-1) for methylisocitrate lyase with threo-2- methylisocitrate as substrate (mixture of (2R,3S)- and (2S,3R)- 2-methylisocitrate at pH 7 and 30 degrees Celsius). {ECO 0000269|PubMed 15723538}; # BRENDA 4.1.3.30 2026 # BioGrid 4259808 9 # CATALYTIC ACTIVITY PRPB_ECOLI (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate. {ECO 0000255|HAMAP-Rule MF_01939, ECO 0000269|PubMed 11422389, ECO 0000269|PubMed 15723538}. # COFACTOR PRPB_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_01939, ECO 0000269|PubMed 11422389, ECO 0000269|PubMed 12706720, ECO 0000269|PubMed 15723538}; # EcoGene EG13601 prpB # FUNCTION PRPB_ECOLI Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate via an alpha-carboxy-carbanion intermediate. {ECO 0000255|HAMAP- Rule MF_01939, ECO 0000269|PubMed 11422389, ECO 0000269|PubMed 15723538}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0000287 magnesium ion binding; IDA:UniProtKB. # GO_function GO:0046421 methylisocitrate lyase activity; IDA:UniProtKB. # GO_function GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer; IBA:GO_Central. # GO_process GO:0006097 glyoxylate cycle; IBA:GO_Central. # GO_process GO:0019629 propionate catabolic process, 2-methylcitrate cycle; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.60 -; 1. # HAMAP MF_01939 PrpB # IntAct P77541 12 # InterPro IPR012695 PrpB # InterPro IPR015813 Pyrv/PenolPyrv_Kinase-like_dom # InterPro IPR018523 Isocitrate_lyase_ph_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00640 Propanoate metabolism # Organism PRPB_ECOLI Escherichia coli (strain K12) # PATHWAY PRPB_ECOLI Organic acid metabolism; propanoate degradation. {ECO 0000255|HAMAP-Rule MF_01939, ECO 0000305|PubMed 9325432}. # PATRIC 32115795 VBIEscCol129921_0339 # PDB 1MUM X-ray; 1.90 A; A/B=2-296 # PDB 1MZX Model; -; A=3-290 # PDB 1OQF X-ray; 1.93 A; A/B=2-296 # PDB 1XG3 X-ray; 1.90 A; A/B/C/D=2-296 # PDB 1XG4 X-ray; 1.60 A; A/B/C/D=2-296 # PIR C64760 C64760 # PROSITE PS00161 ISOCITRATE_LYASE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 2-methylisocitrate lyase {ECO:0000303|PubMed 11422389} # RefSeq NP_414865 NC_000913.3 # RefSeq WP_000052206 NZ_LN832404.1 # SIMILARITY Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. {ECO:0000255|HAMAP- Rule MF_01939, ECO:0000305}. # SUBUNIT PRPB_ECOLI Homotetramer; dimer of dimers. {ECO 0000255|HAMAP- Rule MF_01939, ECO 0000269|PubMed 12706720, ECO 0000269|PubMed 15723538}. # SUPFAM SSF51621 SSF51621 # TIGRFAMs TIGR02317 prpB # eggNOG COG2513 LUCA # eggNOG ENOG4105CR4 Bacteria BLAST swissprot:PRPB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PRPB_ECOLI BioCyc ECOL316407:JW0323-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0323-MONOMER BioCyc EcoCyc:G6196-MONOMER http://biocyc.org/getid?id=EcoCyc:G6196-MONOMER BioCyc MetaCyc:G6196-MONOMER http://biocyc.org/getid?id=MetaCyc:G6196-MONOMER COG COG2513 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2513 DOI 10.1007/s002030050518 http://dx.doi.org/10.1007/s002030050518 DOI 10.1016/S0022-2836(03)00358-9 http://dx.doi.org/10.1016/S0022-2836(03)00358-9 DOI 10.1021/bi0479712 http://dx.doi.org/10.1021/bi0479712 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1432-1327.2001.02262.x http://dx.doi.org/10.1046/j.1432-1327.2001.02262.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.1.3.30 {ECO:0000269|PubMed:11422389, ECO:0000269|PubMed:15723538} http://www.genome.jp/dbget-bin/www_bget?EC:4.1.3.30 {ECO:0000269|PubMed:11422389, ECO:0000269|PubMed:15723538} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 ENZYME 4.1.3.30 {ECO:0000269|PubMed:11422389, ECO:0000269|PubMed:15723538} http://enzyme.expasy.org/EC/4.1.3.30 {ECO:0000269|PubMed:11422389, ECO:0000269|PubMed:15723538} EchoBASE EB3370 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3370 EcoGene EG13601 http://www.ecogene.org/geneInfo.php?eg_id=EG13601 EnsemblBacteria AAC73434 http://www.ensemblgenomes.org/id/AAC73434 EnsemblBacteria AAC73434 http://www.ensemblgenomes.org/id/AAC73434 EnsemblBacteria BAE76114 http://www.ensemblgenomes.org/id/BAE76114 EnsemblBacteria BAE76114 http://www.ensemblgenomes.org/id/BAE76114 EnsemblBacteria BAE76114 http://www.ensemblgenomes.org/id/BAE76114 EnsemblBacteria b0331 http://www.ensemblgenomes.org/id/b0331 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0046421 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046421 GO_function GO:0046912 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046912 GO_process GO:0006097 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006097 GO_process GO:0019629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019629 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.60 http://www.cathdb.info/version/latest/superfamily/3.20.20.60 GeneID 944990 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944990 HAMAP MF_01939 http://hamap.expasy.org/unirule/MF_01939 HOGENOM HOG000220041 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220041&db=HOGENOM6 InParanoid P77541 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77541 IntAct P77541 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77541* IntEnz 4.1.3.30 {ECO:0000269|PubMed:11422389, ECO:0000269|PubMed:15723538} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.3.30 {ECO:0000269|PubMed:11422389, ECO:0000269|PubMed:15723538} InterPro IPR012695 http://www.ebi.ac.uk/interpro/entry/IPR012695 InterPro IPR015813 http://www.ebi.ac.uk/interpro/entry/IPR015813 InterPro IPR018523 http://www.ebi.ac.uk/interpro/entry/IPR018523 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0323 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0323 KEGG_Gene eco:b0331 http://www.genome.jp/dbget-bin/www_bget?eco:b0331 KEGG_Orthology KO:K03417 http://www.genome.jp/dbget-bin/www_bget?KO:K03417 KEGG_Pathway ko00640 http://www.genome.jp/kegg-bin/show_pathway?ko00640 KEGG_Reaction rn:R00409 http://www.genome.jp/dbget-bin/www_bget?rn:R00409 OMA FGQTELW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FGQTELW PDB 1MUM http://www.ebi.ac.uk/pdbe-srv/view/entry/1MUM PDB 1MZX http://www.ebi.ac.uk/pdbe-srv/view/entry/1MZX PDB 1OQF http://www.ebi.ac.uk/pdbe-srv/view/entry/1OQF PDB 1XG3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1XG3 PDB 1XG4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1XG4 PDBsum 1MUM http://www.ebi.ac.uk/pdbsum/1MUM PDBsum 1MZX http://www.ebi.ac.uk/pdbsum/1MZX PDBsum 1OQF http://www.ebi.ac.uk/pdbsum/1OQF PDBsum 1XG3 http://www.ebi.ac.uk/pdbsum/1XG3 PDBsum 1XG4 http://www.ebi.ac.uk/pdbsum/1XG4 PROSITE PS00161 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00161 PSORT swissprot:PRPB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PRPB_ECOLI PSORT-B swissprot:PRPB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PRPB_ECOLI PSORT2 swissprot:PRPB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PRPB_ECOLI Phobius swissprot:PRPB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PRPB_ECOLI PhylomeDB P77541 http://phylomedb.org/?seqid=P77541 ProteinModelPortal P77541 http://www.proteinmodelportal.org/query/uniprot/P77541 PubMed 11422389 http://www.ncbi.nlm.nih.gov/pubmed/11422389 PubMed 12706720 http://www.ncbi.nlm.nih.gov/pubmed/12706720 PubMed 15723538 http://www.ncbi.nlm.nih.gov/pubmed/15723538 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9325432 http://www.ncbi.nlm.nih.gov/pubmed/9325432 RefSeq NP_414865 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414865 RefSeq WP_000052206 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000052206 SMR P77541 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77541 STRING 511145.b0331 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0331&targetmode=cogs STRING COG2513 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2513&targetmode=cogs SUPFAM SSF51621 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51621 TIGRFAMs TIGR02317 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02317 UniProtKB PRPB_ECOLI http://www.uniprot.org/uniprot/PRPB_ECOLI UniProtKB-AC P77541 http://www.uniprot.org/uniprot/P77541 charge swissprot:PRPB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PRPB_ECOLI eggNOG COG2513 http://eggnogapi.embl.de/nog_data/html/tree/COG2513 eggNOG ENOG4105CR4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CR4 epestfind swissprot:PRPB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PRPB_ECOLI garnier swissprot:PRPB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PRPB_ECOLI helixturnhelix swissprot:PRPB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PRPB_ECOLI hmoment swissprot:PRPB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PRPB_ECOLI iep swissprot:PRPB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PRPB_ECOLI inforesidue swissprot:PRPB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PRPB_ECOLI octanol swissprot:PRPB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PRPB_ECOLI pepcoil swissprot:PRPB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PRPB_ECOLI pepdigest swissprot:PRPB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PRPB_ECOLI pepinfo swissprot:PRPB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PRPB_ECOLI pepnet swissprot:PRPB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PRPB_ECOLI pepstats swissprot:PRPB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PRPB_ECOLI pepwheel swissprot:PRPB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PRPB_ECOLI pepwindow swissprot:PRPB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PRPB_ECOLI sigcleave swissprot:PRPB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PRPB_ECOLI ## Database ID URL or Descriptions # AltName DMSB_ECOLI DMSO reductase iron-sulfur subunit # COFACTOR Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI 49883; Note=Binds 4 [4Fe-4S] clusters.; # EcoGene EG10233 dmsB # FUNCTION DMSB_ECOLI Electron transfer subunit of the terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_component GO:0009390 dimethyl sulfoxide reductase complex; IDA:EcoCyc. # GO_component GO:0031237 intrinsic component of periplasmic side of plasma membrane; IDA:EcoCyc. # GO_function GO:0009389 dimethyl sulfoxide reductase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IDA:EcoCyc. # GO_process GO:0009061 anaerobic respiration; IEP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # INTERACTION DMSB_ECOLI P18775 dmsA; NbExp=2; IntAct=EBI-1120825, EBI-4411104; # IntAct P18776 6 # InterPro IPR014297 DMSO_DmsB # InterPro IPR017896 4Fe4S_Fe-S-bd # InterPro IPR017900 4Fe4S_Fe_S_CS # KEGG_Brite ko02000 Transporters # Organism DMSB_ECOLI Escherichia coli (strain K12) # PATRIC 32117001 VBIEscCol129921_0925 # PIR F64828 F64828 # PROSITE PS00198 4FE4S_FER_1 # PROSITE PS51379 4FE4S_FER_2; 3 # Pfam PF12800 Fer4_4 # Pfam PF13247 Fer4_11 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DMSB_ECOLI Anaerobic dimethyl sulfoxide reductase chain B # RefSeq NP_415415 NC_000913.3 # RefSeq WP_000213098 NZ_LN832404.1 # SIMILARITY Contains 3 4Fe-4S ferredoxin-type domains. {ECO:0000255|PROSITE-ProRule PRU00711}. # SUBUNIT DMSB_ECOLI Heterotrimeric enzyme composed of a catalytic heterodimer (DmsAB) and a membrane anchor protein (DmsC). # TCDB 5.A.3.3 the prokaryotic molybdopterin-containing oxidoreductase (pmo) family # TIGRFAMs TIGR02951 DMSO_dmsB # eggNOG COG0437 LUCA # eggNOG ENOG4105QAX Bacteria BLAST swissprot:DMSB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DMSB_ECOLI BioCyc ECOL316407:JW0878-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0878-MONOMER BioCyc EcoCyc:DMSB-MONOMER http://biocyc.org/getid?id=EcoCyc:DMSB-MONOMER BioCyc MetaCyc:DMSB-MONOMER http://biocyc.org/getid?id=MetaCyc:DMSB-MONOMER COG COG0437 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0437 DIP DIP-9453N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9453N DOI 10.1021/bi00098a003 http://dx.doi.org/10.1021/bi00098a003 DOI 10.1021/bi00488a030 http://dx.doi.org/10.1021/bi00488a030 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1988.tb00090.x http://dx.doi.org/10.1111/j.1365-2958.1988.tb00090.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J03412 http://www.ebi.ac.uk/ena/data/view/J03412 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0229 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0229 EcoGene EG10233 http://www.ecogene.org/geneInfo.php?eg_id=EG10233 EnsemblBacteria AAC73981 http://www.ensemblgenomes.org/id/AAC73981 EnsemblBacteria AAC73981 http://www.ensemblgenomes.org/id/AAC73981 EnsemblBacteria BAA35627 http://www.ensemblgenomes.org/id/BAA35627 EnsemblBacteria BAA35627 http://www.ensemblgenomes.org/id/BAA35627 EnsemblBacteria BAA35627 http://www.ensemblgenomes.org/id/BAA35627 EnsemblBacteria b0895 http://www.ensemblgenomes.org/id/b0895 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0009390 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009390 GO_component GO:0031237 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031237 GO_function GO:0009389 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009389 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0009061 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009061 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GeneID 945507 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945507 HOGENOM HOG000163387 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000163387&db=HOGENOM6 InParanoid P18776 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P18776 IntAct P18776 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P18776* InterPro IPR014297 http://www.ebi.ac.uk/interpro/entry/IPR014297 InterPro IPR017896 http://www.ebi.ac.uk/interpro/entry/IPR017896 InterPro IPR017900 http://www.ebi.ac.uk/interpro/entry/IPR017900 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0878 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0878 KEGG_Gene eco:b0895 http://www.genome.jp/dbget-bin/www_bget?eco:b0895 KEGG_Orthology KO:K07307 http://www.genome.jp/dbget-bin/www_bget?KO:K07307 OMA FKRHFDI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FKRHFDI PROSITE PS00198 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00198 PROSITE PS51379 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51379 PSORT swissprot:DMSB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DMSB_ECOLI PSORT-B swissprot:DMSB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DMSB_ECOLI PSORT2 swissprot:DMSB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DMSB_ECOLI Pfam PF12800 http://pfam.xfam.org/family/PF12800 Pfam PF13247 http://pfam.xfam.org/family/PF13247 Phobius swissprot:DMSB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DMSB_ECOLI PhylomeDB P18776 http://phylomedb.org/?seqid=P18776 ProteinModelPortal P18776 http://www.proteinmodelportal.org/query/uniprot/P18776 PubMed 1653010 http://www.ncbi.nlm.nih.gov/pubmed/1653010 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2174699 http://www.ncbi.nlm.nih.gov/pubmed/2174699 PubMed 3062312 http://www.ncbi.nlm.nih.gov/pubmed/3062312 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415415 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415415 RefSeq WP_000213098 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000213098 SMR P18776 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P18776 STRING 511145.b0895 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0895&targetmode=cogs STRING COG0437 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0437&targetmode=cogs TCDB 5.A.3.3 http://www.tcdb.org/search/result.php?tc=5.A.3.3 TIGRFAMs TIGR02951 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02951 UniProtKB DMSB_ECOLI http://www.uniprot.org/uniprot/DMSB_ECOLI UniProtKB-AC P18776 http://www.uniprot.org/uniprot/P18776 charge swissprot:DMSB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DMSB_ECOLI eggNOG COG0437 http://eggnogapi.embl.de/nog_data/html/tree/COG0437 eggNOG ENOG4105QAX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105QAX epestfind swissprot:DMSB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DMSB_ECOLI garnier swissprot:DMSB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DMSB_ECOLI helixturnhelix swissprot:DMSB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DMSB_ECOLI hmoment swissprot:DMSB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DMSB_ECOLI iep swissprot:DMSB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DMSB_ECOLI inforesidue swissprot:DMSB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DMSB_ECOLI octanol swissprot:DMSB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DMSB_ECOLI pepcoil swissprot:DMSB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DMSB_ECOLI pepdigest swissprot:DMSB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DMSB_ECOLI pepinfo swissprot:DMSB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DMSB_ECOLI pepnet swissprot:DMSB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DMSB_ECOLI pepstats swissprot:DMSB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DMSB_ECOLI pepwheel swissprot:DMSB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DMSB_ECOLI pepwindow swissprot:DMSB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DMSB_ECOLI sigcleave swissprot:DMSB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DMSB_ECOLI ## Database ID URL or Descriptions # BioGrid 4261632 8 # CDD cd06170 LuxR_C_like # EcoGene EG10643 narL # FUNCTION NARL_ECOLI This protein activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal transmitted by either the NarX or NarQ proteins. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IMP:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0000160 phosphorelay signal transduction system; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IMP:EcoCyc. # GO_process GO:0010468 regulation of gene expression; IMP:EcoCyc. # GO_process GO:0042128 nitrate assimilation; IEA:UniProtKB-KW. # GO_process GO:0090352 regulation of nitrate assimilation; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0071941 nitrogen cycle metabolic process # Gene3D 1.10.10.10 -; 1. # IntAct P0AF28 4 # InterPro IPR000792 Tscrpt_reg_LuxR_C # InterPro IPR001789 Sig_transdc_resp-reg_receiver # InterPro IPR011006 CheY-like_superfamily # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR016032 Sig_transdc_resp-reg_C-effctor # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02022 M00471 NarX-NarL (nitrate respiration) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # Organism NARL_ECOLI Escherichia coli (strain K12) # PATRIC 32117700 VBIEscCol129921_1272 # PDB 1A04 X-ray; 2.20 A; A/B=2-216 # PDB 1JE8 X-ray; 2.12 A; A/B/E/F=147-216 # PDB 1RNL X-ray; 2.40 A; A=2-216 # PDB 1ZG1 X-ray; 2.30 A; A/B/E/F=147-216 # PDB 1ZG5 X-ray; 2.30 A; A/B/E/F=147-216 # PIR S09285 RGECNL # PRINTS PR00038 HTHLUXR # PROSITE PS00622 HTH_LUXR_1 # PROSITE PS50043 HTH_LUXR_2 # PROSITE PS50110 RESPONSE_REGULATORY # Pfam PF00072 Response_reg # Pfam PF00196 GerE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NARL_ECOLI Nitrate/nitrite response regulator protein NarL # RefSeq NP_415739 NC_000913.3 # RefSeq WP_000070491 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA33023.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Contains 1 HTH luxR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00411}. # SIMILARITY Contains 1 response regulatory domain. {ECO:0000255|PROSITE-ProRule PRU00169}. # SMART SM00421 HTH_LUXR # SMART SM00448 REC # SUPFAM SSF46894 SSF46894 # SUPFAM SSF52172 SSF52172 # eggNOG COG2197 LUCA # eggNOG ENOG4105WH1 Bacteria BLAST swissprot:NARL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NARL_ECOLI BioCyc ECOL316407:JW1212-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1212-MONOMER BioCyc EcoCyc:NARL-MONOMER http://biocyc.org/getid?id=EcoCyc:NARL-MONOMER COG COG2197 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2197 DIP DIP-35941N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35941N DOI 10.1021/bi960919o http://dx.doi.org/10.1021/bi960919o DOI 10.1021/bi972365a http://dx.doi.org/10.1021/bi972365a DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/17.5.1965 http://dx.doi.org/10.1093/nar/17.5.1965 DOI 10.1093/nar/17.8.2947 http://dx.doi.org/10.1093/nar/17.8.2947 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M24910 http://www.ebi.ac.uk/ena/data/view/M24910 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X13360 http://www.ebi.ac.uk/ena/data/view/X13360 EMBL X14884 http://www.ebi.ac.uk/ena/data/view/X14884 EMBL X69189 http://www.ebi.ac.uk/ena/data/view/X69189 EchoBASE EB0637 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0637 EcoGene EG10643 http://www.ecogene.org/geneInfo.php?eg_id=EG10643 EnsemblBacteria AAC74305 http://www.ensemblgenomes.org/id/AAC74305 EnsemblBacteria AAC74305 http://www.ensemblgenomes.org/id/AAC74305 EnsemblBacteria BAA36089 http://www.ensemblgenomes.org/id/BAA36089 EnsemblBacteria BAA36089 http://www.ensemblgenomes.org/id/BAA36089 EnsemblBacteria BAA36089 http://www.ensemblgenomes.org/id/BAA36089 EnsemblBacteria b1221 http://www.ensemblgenomes.org/id/b1221 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0010468 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010468 GO_process GO:0042128 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042128 GO_process GO:0090352 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090352 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0071941 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071941 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 945795 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945795 HOGENOM HOG000034813 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000034813&db=HOGENOM6 InParanoid P0AF28 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AF28 IntAct P0AF28 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AF28* InterPro IPR000792 http://www.ebi.ac.uk/interpro/entry/IPR000792 InterPro IPR001789 http://www.ebi.ac.uk/interpro/entry/IPR001789 InterPro IPR011006 http://www.ebi.ac.uk/interpro/entry/IPR011006 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR016032 http://www.ebi.ac.uk/interpro/entry/IPR016032 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW1212 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1212 KEGG_Gene eco:b1221 http://www.genome.jp/dbget-bin/www_bget?eco:b1221 KEGG_Orthology KO:K07684 http://www.genome.jp/dbget-bin/www_bget?KO:K07684 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA IRATFHG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IRATFHG PDB 1A04 http://www.ebi.ac.uk/pdbe-srv/view/entry/1A04 PDB 1JE8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1JE8 PDB 1RNL http://www.ebi.ac.uk/pdbe-srv/view/entry/1RNL PDB 1ZG1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZG1 PDB 1ZG5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZG5 PDBsum 1A04 http://www.ebi.ac.uk/pdbsum/1A04 PDBsum 1JE8 http://www.ebi.ac.uk/pdbsum/1JE8 PDBsum 1RNL http://www.ebi.ac.uk/pdbsum/1RNL PDBsum 1ZG1 http://www.ebi.ac.uk/pdbsum/1ZG1 PDBsum 1ZG5 http://www.ebi.ac.uk/pdbsum/1ZG5 PRINTS PR00038 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00038 PROSITE PS00622 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00622 PROSITE PS50043 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50043 PROSITE PS50110 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50110 PSORT swissprot:NARL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NARL_ECOLI PSORT-B swissprot:NARL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NARL_ECOLI PSORT2 swissprot:NARL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NARL_ECOLI Pfam PF00072 http://pfam.xfam.org/family/PF00072 Pfam PF00196 http://pfam.xfam.org/family/PF00196 Phobius swissprot:NARL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NARL_ECOLI PhylomeDB P0AF28 http://phylomedb.org/?seqid=P0AF28 ProteinModelPortal P0AF28 http://www.proteinmodelportal.org/query/uniprot/P0AF28 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2066339 http://www.ncbi.nlm.nih.gov/pubmed/2066339 PubMed 2648330 http://www.ncbi.nlm.nih.gov/pubmed/2648330 PubMed 2649492 http://www.ncbi.nlm.nih.gov/pubmed/2649492 PubMed 2657652 http://www.ncbi.nlm.nih.gov/pubmed/2657652 PubMed 8780507 http://www.ncbi.nlm.nih.gov/pubmed/8780507 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9521685 http://www.ncbi.nlm.nih.gov/pubmed/9521685 RefSeq NP_415739 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415739 RefSeq WP_000070491 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000070491 SMART SM00421 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00421 SMART SM00448 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00448 SMR P0AF28 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AF28 STRING 511145.b1221 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1221&targetmode=cogs STRING COG2197 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2197&targetmode=cogs SUPFAM SSF46894 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46894 SUPFAM SSF52172 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52172 UniProtKB NARL_ECOLI http://www.uniprot.org/uniprot/NARL_ECOLI UniProtKB-AC P0AF28 http://www.uniprot.org/uniprot/P0AF28 charge swissprot:NARL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NARL_ECOLI eggNOG COG2197 http://eggnogapi.embl.de/nog_data/html/tree/COG2197 eggNOG ENOG4105WH1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105WH1 epestfind swissprot:NARL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NARL_ECOLI garnier swissprot:NARL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NARL_ECOLI helixturnhelix swissprot:NARL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NARL_ECOLI hmoment swissprot:NARL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NARL_ECOLI iep swissprot:NARL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NARL_ECOLI inforesidue swissprot:NARL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NARL_ECOLI octanol swissprot:NARL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NARL_ECOLI pepcoil swissprot:NARL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NARL_ECOLI pepdigest swissprot:NARL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NARL_ECOLI pepinfo swissprot:NARL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NARL_ECOLI pepnet swissprot:NARL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NARL_ECOLI pepstats swissprot:NARL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NARL_ECOLI pepwheel swissprot:NARL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NARL_ECOLI pepwindow swissprot:NARL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NARL_ECOLI sigcleave swissprot:NARL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NARL_ECOLI ## Database ID URL or Descriptions # AltName RSMI_ECOLI 16S rRNA 2'-O-ribose C1402 methyltransferase # AltName RSMI_ECOLI rRNA (cytidine-2'-O-)-methyltransferase RsmI # BRENDA 2.1.1.198 2026 # BioGrid 4261593 49 # CATALYTIC ACTIVITY S-adenosyl-L-methionine + cytidine(1402) in 16S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine(1402) in 16S rRNA. {ECO:0000269|PubMed 19965768}. # CDD cd11648 RsmI # EcoGene EG12777 rsmI # FUNCTION RSMI_ECOLI Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. In vitro, active on the assembled 30S subunit, but not naked 16S rRNA or 70S ribosomes. {ECO 0000269|PubMed 19965768}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0070677 rRNA (cytosine-2'-O-)-methyltransferase activity; IDA:EcoCyc. # GO_process GO:0000453 enzyme-directed rRNA 2'-O-methylation; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.30.950.10 -; 1. # Gene3D 3.40.1010.10 -; 1. # HAMAP MF_01877 16SrRNA_methyltr_I # IntAct P67087 3 # InterPro IPR000878 4pyrrol_Mease # InterPro IPR008189 rRNA_ssu_MeTfrase_I # InterPro IPR014776 4pyrrole_Mease_sub2 # InterPro IPR014777 4pyrrole_Mease_sub1 # InterPro IPR018063 SAM_MeTrfase_RsmI_CS # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # Organism RSMI_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21091:SF18 PTHR21091:SF18 # PATRIC 32121710 VBIEscCol129921_3241 # PDB 5HW4 X-ray; 2.21 A; A/B/C=12-258 # PIR F65104 F65104 # PIRSF PIRSF005917 MTase_YraL # PROSITE PS01296 RSMI # Pfam PF00590 TP_methylase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RSMI_ECOLI Ribosomal RNA small subunit methyltransferase I # RefSeq NP_417615 NC_000913.3 # RefSeq WP_000809262 NZ_LN832404.1 # SIMILARITY Belongs to the methyltransferase superfamily. RsmI family. {ECO 0000305}. # SUBCELLULAR LOCATION RSMI_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF53790 SSF53790 # TIGRFAMs TIGR00096 TIGR00096 # eggNOG COG0313 LUCA # eggNOG ENOG4105CU0 Bacteria BLAST swissprot:RSMI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RSMI_ECOLI BioCyc ECOL316407:JW3115-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3115-MONOMER BioCyc EcoCyc:G7641-MONOMER http://biocyc.org/getid?id=EcoCyc:G7641-MONOMER BioCyc MetaCyc:G7641-MONOMER http://biocyc.org/getid?id=MetaCyc:G7641-MONOMER COG COG0313 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0313 DIP DIP-12896N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12896N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkp1073 http://dx.doi.org/10.1093/nar/gkp1073 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.1.198 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.198 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 2.1.1.198 http://enzyme.expasy.org/EC/2.1.1.198 EchoBASE EB2630 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2630 EcoGene EG12777 http://www.ecogene.org/geneInfo.php?eg_id=EG12777 EnsemblBacteria AAC76180 http://www.ensemblgenomes.org/id/AAC76180 EnsemblBacteria AAC76180 http://www.ensemblgenomes.org/id/AAC76180 EnsemblBacteria BAE77192 http://www.ensemblgenomes.org/id/BAE77192 EnsemblBacteria BAE77192 http://www.ensemblgenomes.org/id/BAE77192 EnsemblBacteria BAE77192 http://www.ensemblgenomes.org/id/BAE77192 EnsemblBacteria b3146 http://www.ensemblgenomes.org/id/b3146 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0070677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070677 GO_process GO:0000453 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000453 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.30.950.10 http://www.cathdb.info/version/latest/superfamily/3.30.950.10 Gene3D 3.40.1010.10 http://www.cathdb.info/version/latest/superfamily/3.40.1010.10 GeneID 947664 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947664 HAMAP MF_01877 http://hamap.expasy.org/unirule/MF_01877 HOGENOM HOG000195941 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000195941&db=HOGENOM6 InParanoid P67087 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P67087 IntAct P67087 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P67087* IntEnz 2.1.1.198 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.198 InterPro IPR000878 http://www.ebi.ac.uk/interpro/entry/IPR000878 InterPro IPR008189 http://www.ebi.ac.uk/interpro/entry/IPR008189 InterPro IPR014776 http://www.ebi.ac.uk/interpro/entry/IPR014776 InterPro IPR014777 http://www.ebi.ac.uk/interpro/entry/IPR014777 InterPro IPR018063 http://www.ebi.ac.uk/interpro/entry/IPR018063 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW3115 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3115 KEGG_Gene eco:b3146 http://www.genome.jp/dbget-bin/www_bget?eco:b3146 KEGG_Orthology KO:K07056 http://www.genome.jp/dbget-bin/www_bget?KO:K07056 MINT MINT-1312386 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1312386 OMA CEDTRNT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CEDTRNT PANTHER PTHR21091:SF18 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21091:SF18 PDB 5HW4 http://www.ebi.ac.uk/pdbe-srv/view/entry/5HW4 PDBsum 5HW4 http://www.ebi.ac.uk/pdbsum/5HW4 PROSITE PS01296 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01296 PSORT swissprot:RSMI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RSMI_ECOLI PSORT-B swissprot:RSMI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RSMI_ECOLI PSORT2 swissprot:RSMI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RSMI_ECOLI Pfam PF00590 http://pfam.xfam.org/family/PF00590 Phobius swissprot:RSMI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RSMI_ECOLI PhylomeDB P67087 http://phylomedb.org/?seqid=P67087 ProteinModelPortal P67087 http://www.proteinmodelportal.org/query/uniprot/P67087 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19965768 http://www.ncbi.nlm.nih.gov/pubmed/19965768 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417615 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417615 RefSeq WP_000809262 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000809262 SMR P67087 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P67087 STRING 511145.b3146 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3146&targetmode=cogs STRING COG0313 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0313&targetmode=cogs SUPFAM SSF53790 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53790 TIGRFAMs TIGR00096 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00096 UniProtKB RSMI_ECOLI http://www.uniprot.org/uniprot/RSMI_ECOLI UniProtKB-AC P67087 http://www.uniprot.org/uniprot/P67087 charge swissprot:RSMI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RSMI_ECOLI eggNOG COG0313 http://eggnogapi.embl.de/nog_data/html/tree/COG0313 eggNOG ENOG4105CU0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CU0 epestfind swissprot:RSMI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RSMI_ECOLI garnier swissprot:RSMI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RSMI_ECOLI helixturnhelix swissprot:RSMI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RSMI_ECOLI hmoment swissprot:RSMI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RSMI_ECOLI iep swissprot:RSMI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RSMI_ECOLI inforesidue swissprot:RSMI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RSMI_ECOLI octanol swissprot:RSMI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RSMI_ECOLI pepcoil swissprot:RSMI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RSMI_ECOLI pepdigest swissprot:RSMI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RSMI_ECOLI pepinfo swissprot:RSMI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RSMI_ECOLI pepnet swissprot:RSMI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RSMI_ECOLI pepstats swissprot:RSMI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RSMI_ECOLI pepwheel swissprot:RSMI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RSMI_ECOLI pepwindow swissprot:RSMI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RSMI_ECOLI sigcleave swissprot:RSMI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RSMI_ECOLI ## Database ID URL or Descriptions # BioGrid 4262414 8 # EcoGene EG12762 agaR # FUNCTION AGAR_ECOLI Probable repressor for the aga operon for N-acetyl galactosamine transport and metabolism. # GO_component GO:0005622 intracellular; IEA:InterPro. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IMP:EcoCyc. # GOslim_component GO:0005622 intracellular # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # IntAct P0ACK2 4 # InterPro IPR001034 DeoR_HTH # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR014036 DeoR_C # InterPro IPR018356 Tscrpt_reg_HTH_DeoR_CS # KEGG_Brite ko03000 Transcription factors # Organism AGAR_ECOLI Escherichia coli (strain K12) # PATRIC 32121678 VBIEscCol129921_3225 # PIR G65102 G65102 # PROSITE PS00894 HTH_DEOR_1 # PROSITE PS51000 HTH_DEOR_2 # Pfam PF00455 DeoRC # Pfam PF08220 HTH_DeoR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AGAR_ECOLI Putative aga operon transcriptional repressor # RefSeq NP_417600 NC_000913.3 # RefSeq WP_000072187 NZ_LN832404.1 # SIMILARITY Contains 1 HTH deoR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00349}. # SMART SM00420 HTH_DEOR # SUPFAM SSF46785 SSF46785 # eggNOG COG1349 LUCA # eggNOG ENOG4105E98 Bacteria BLAST swissprot:AGAR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AGAR_ECOLI BioCyc ECOL316407:JW3100-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3100-MONOMER BioCyc EcoCyc:G7630-MONOMER http://biocyc.org/getid?id=EcoCyc:G7630-MONOMER COG COG1349 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1349 DIP DIP-48095N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48095N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2000.01969.x http://dx.doi.org/10.1046/j.1365-2958.2000.01969.x DOI 10.1099/13500872-142-2-231 http://dx.doi.org/10.1099/13500872-142-2-231 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AF228498 http://www.ebi.ac.uk/ena/data/view/AF228498 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2615 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2615 EcoGene EG12762 http://www.ecogene.org/geneInfo.php?eg_id=EG12762 EnsemblBacteria AAC76165 http://www.ensemblgenomes.org/id/AAC76165 EnsemblBacteria AAC76165 http://www.ensemblgenomes.org/id/AAC76165 EnsemblBacteria BAE77178 http://www.ensemblgenomes.org/id/BAE77178 EnsemblBacteria BAE77178 http://www.ensemblgenomes.org/id/BAE77178 EnsemblBacteria BAE77178 http://www.ensemblgenomes.org/id/BAE77178 EnsemblBacteria b3131 http://www.ensemblgenomes.org/id/b3131 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 947636 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947636 HOGENOM HOG000224684 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000224684&db=HOGENOM6 InParanoid P0ACK2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACK2 IntAct P0ACK2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACK2* InterPro IPR001034 http://www.ebi.ac.uk/interpro/entry/IPR001034 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR014036 http://www.ebi.ac.uk/interpro/entry/IPR014036 InterPro IPR018356 http://www.ebi.ac.uk/interpro/entry/IPR018356 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW3100 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3100 KEGG_Gene eco:b3131 http://www.genome.jp/dbget-bin/www_bget?eco:b3131 KEGG_Orthology KO:K02081 http://www.genome.jp/dbget-bin/www_bget?KO:K02081 MINT MINT-1304785 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1304785 OMA KMCEVAE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KMCEVAE PROSITE PS00894 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00894 PROSITE PS51000 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51000 PSORT swissprot:AGAR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AGAR_ECOLI PSORT-B swissprot:AGAR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AGAR_ECOLI PSORT2 swissprot:AGAR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AGAR_ECOLI Pfam PF00455 http://pfam.xfam.org/family/PF00455 Pfam PF08220 http://pfam.xfam.org/family/PF08220 Phobius swissprot:AGAR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AGAR_ECOLI PhylomeDB P0ACK2 http://phylomedb.org/?seqid=P0ACK2 ProteinModelPortal P0ACK2 http://www.proteinmodelportal.org/query/uniprot/P0ACK2 PubMed 10931310 http://www.ncbi.nlm.nih.gov/pubmed/10931310 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8932697 http://www.ncbi.nlm.nih.gov/pubmed/8932697 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417600 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417600 RefSeq WP_000072187 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000072187 SMART SM00420 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00420 SMR P0ACK2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACK2 STRING 511145.b3131 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3131&targetmode=cogs STRING COG1349 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1349&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB AGAR_ECOLI http://www.uniprot.org/uniprot/AGAR_ECOLI UniProtKB-AC P0ACK2 http://www.uniprot.org/uniprot/P0ACK2 charge swissprot:AGAR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AGAR_ECOLI eggNOG COG1349 http://eggnogapi.embl.de/nog_data/html/tree/COG1349 eggNOG ENOG4105E98 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E98 epestfind swissprot:AGAR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AGAR_ECOLI garnier swissprot:AGAR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AGAR_ECOLI helixturnhelix swissprot:AGAR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AGAR_ECOLI hmoment swissprot:AGAR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AGAR_ECOLI iep swissprot:AGAR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AGAR_ECOLI inforesidue swissprot:AGAR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AGAR_ECOLI octanol swissprot:AGAR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AGAR_ECOLI pepcoil swissprot:AGAR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AGAR_ECOLI pepdigest swissprot:AGAR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AGAR_ECOLI pepinfo swissprot:AGAR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AGAR_ECOLI pepnet swissprot:AGAR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AGAR_ECOLI pepstats swissprot:AGAR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AGAR_ECOLI pepwheel swissprot:AGAR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AGAR_ECOLI pepwindow swissprot:AGAR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AGAR_ECOLI sigcleave swissprot:AGAR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AGAR_ECOLI ## Database ID URL or Descriptions # BioGrid 4260521 17 # DISRUPTION PHENOTYPE Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain. {ECO:0000269|PubMed 20345943}. # EcoGene EG14122 yfcS # FUNCTION YFCS_ECOLI Part of the yfcOPQRSUV fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes. {ECO 0000269|PubMed 20345943}. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IEA:InterPro. # GO_process GO:0043711 pilus organization; IEA:InterPro. # GO_process GO:0061077 chaperone-mediated protein folding; IEA:InterPro. # GO_process GO:0071555 cell wall organization; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0006457 protein folding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 2.60.40.1070 -; 1. # Gene3D 2.60.40.360 -; 1. # INDUCTION Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression. {ECO:0000269|PubMed 20345943}. # InterPro IPR001829 Pili_assmbl_chaperone_bac # InterPro IPR008962 PapD-like # InterPro IPR016147 Pili_assmbl_chaperone_N # InterPro IPR016148 Pili_assmbl_chaperone_C # InterPro IPR018046 Pili_assmbl_chaperone_CS # MISCELLANEOUS The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed. {ECO:0000305|PubMed 20345943}. # Organism YFCS_ECOLI Escherichia coli (strain K12) # PATRIC 32120045 VBIEscCol129921_2432 # PIR F65006 F65006 # PRINTS PR00969 CHAPERONPILI # PROSITE PS00635 PILI_CHAPERONE # Pfam PF00345 PapD_N # Pfam PF02753 PapD_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFCS_ECOLI Probable fimbrial chaperone YfcS # RefSeq NP_416839 NC_000913.3 # RefSeq WP_001281606 NZ_LN832404.1 # SIMILARITY Belongs to the periplasmic pilus chaperone family. {ECO 0000305}. # SIMILARITY Contains 1 Ig-like (immunoglobulin-like) domain. {ECO 0000305}. # SUBCELLULAR LOCATION YFCS_ECOLI Periplasm {ECO 0000250}. # SUPFAM SSF49354 SSF49354 # SUPFAM SSF49584 SSF49584 # eggNOG COG3121 LUCA # eggNOG ENOG4108FZ9 Bacteria BLAST swissprot:YFCS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFCS_ECOLI BioCyc ECOL316407:JW2333-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2333-MONOMER BioCyc EcoCyc:G7207-MONOMER http://biocyc.org/getid?id=EcoCyc:G7207-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1462-2920.2010.02202.x http://dx.doi.org/10.1111/j.1462-2920.2010.02202.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3875 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3875 EcoGene EG14122 http://www.ecogene.org/geneInfo.php?eg_id=EG14122 EnsemblBacteria AAC75396 http://www.ensemblgenomes.org/id/AAC75396 EnsemblBacteria AAC75396 http://www.ensemblgenomes.org/id/AAC75396 EnsemblBacteria BAA16190 http://www.ensemblgenomes.org/id/BAA16190 EnsemblBacteria BAA16190 http://www.ensemblgenomes.org/id/BAA16190 EnsemblBacteria BAA16190 http://www.ensemblgenomes.org/id/BAA16190 EnsemblBacteria b2336 http://www.ensemblgenomes.org/id/b2336 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_process GO:0043711 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043711 GO_process GO:0061077 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061077 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 2.60.40.1070 http://www.cathdb.info/version/latest/superfamily/2.60.40.1070 Gene3D 2.60.40.360 http://www.cathdb.info/version/latest/superfamily/2.60.40.360 GeneID 946418 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946418 HOGENOM HOG000260153 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260153&db=HOGENOM6 IntAct P77599 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77599* InterPro IPR001829 http://www.ebi.ac.uk/interpro/entry/IPR001829 InterPro IPR008962 http://www.ebi.ac.uk/interpro/entry/IPR008962 InterPro IPR016147 http://www.ebi.ac.uk/interpro/entry/IPR016147 InterPro IPR016148 http://www.ebi.ac.uk/interpro/entry/IPR016148 InterPro IPR018046 http://www.ebi.ac.uk/interpro/entry/IPR018046 KEGG_Gene ecj:JW2333 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2333 KEGG_Gene eco:b2336 http://www.genome.jp/dbget-bin/www_bget?eco:b2336 OMA DNPWQEK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DNPWQEK PRINTS PR00969 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00969 PROSITE PS00635 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00635 PSORT swissprot:YFCS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFCS_ECOLI PSORT-B swissprot:YFCS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFCS_ECOLI PSORT2 swissprot:YFCS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFCS_ECOLI Pfam PF00345 http://pfam.xfam.org/family/PF00345 Pfam PF02753 http://pfam.xfam.org/family/PF02753 Phobius swissprot:YFCS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFCS_ECOLI PhylomeDB P77599 http://phylomedb.org/?seqid=P77599 ProteinModelPortal P77599 http://www.proteinmodelportal.org/query/uniprot/P77599 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20345943 http://www.ncbi.nlm.nih.gov/pubmed/20345943 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416839 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416839 RefSeq WP_001281606 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001281606 SMR P77599 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77599 STRING 511145.b2336 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2336&targetmode=cogs SUPFAM SSF49354 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49354 SUPFAM SSF49584 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49584 UniProtKB YFCS_ECOLI http://www.uniprot.org/uniprot/YFCS_ECOLI UniProtKB-AC P77599 http://www.uniprot.org/uniprot/P77599 charge swissprot:YFCS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFCS_ECOLI eggNOG COG3121 http://eggnogapi.embl.de/nog_data/html/tree/COG3121 eggNOG ENOG4108FZ9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108FZ9 epestfind swissprot:YFCS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFCS_ECOLI garnier swissprot:YFCS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFCS_ECOLI helixturnhelix swissprot:YFCS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFCS_ECOLI hmoment swissprot:YFCS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFCS_ECOLI iep swissprot:YFCS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFCS_ECOLI inforesidue swissprot:YFCS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFCS_ECOLI octanol swissprot:YFCS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFCS_ECOLI pepcoil swissprot:YFCS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFCS_ECOLI pepdigest swissprot:YFCS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFCS_ECOLI pepinfo swissprot:YFCS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFCS_ECOLI pepnet swissprot:YFCS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFCS_ECOLI pepstats swissprot:YFCS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFCS_ECOLI pepwheel swissprot:YFCS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFCS_ECOLI pepwindow swissprot:YFCS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFCS_ECOLI sigcleave swissprot:YFCS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFCS_ECOLI ## Database ID URL or Descriptions # BioGrid 4262138 6 # EcoGene EG10116 bglG # FUNCTION BGLG_ECOLI Mediates the positive regulation of the beta-glucoside (bgl) operon by functioning as a transcriptional antiterminator. This is an RNA-binding protein that recognizes a specific sequence located just upstream of two termination sites within the operon. # GO_function GO:0003723 RNA binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IEA:InterPro. # GOslim_function GO:0003723 RNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.1790.10 -; 2. # Gene3D 2.30.24.10 -; 1. # INTERACTION BGLG_ECOLI P06710 dnaX; NbExp=3; IntAct=EBI-545674, EBI-549140; P0AA04 ptsH; NbExp=5; IntAct=EBI-545674, EBI-902853; P08839 ptsI; NbExp=3; IntAct=EBI-545674, EBI-551533; P77700 yahB; NbExp=3; IntAct=EBI-545674, EBI-545731; # IntAct P11989 14 # InterPro IPR001550 Transcrpt_antitermin_CS # InterPro IPR004341 CAT_RNA-bd_dom # InterPro IPR011608 PRD # KEGG_Brite ko03000 Transcription factors # Organism BGLG_ECOLI Escherichia coli (strain K12) # PATRIC 32122941 VBIEscCol129921_3846 # PIR B25977 B25977 # PROSITE PS00654 PRD_1 # PROSITE PS51372 PRD_2; 2 # PTM BGLG_ECOLI Phosphorylated and inactivated by BglF (eII-bgl). The degree of phosphorylation is dependent on the presence or absence of beta-glucosides which act as inducers of the operon expression. Addition of inducer result in the rapid dephosphorylation of BglG. # Pfam PF00874 PRD; 2 # Pfam PF03123 CAT_RBD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BGLG_ECOLI Cryptic beta-glucoside bgl operon antiterminator # RefSeq NP_418179 NC_000913.3 # RefSeq WP_001295251 NZ_LN832404.1 # SIMILARITY Belongs to the transcriptional antiterminator BglG family. {ECO 0000305}. # SIMILARITY Contains 2 PRD domains. {ECO:0000255|PROSITE- ProRule PRU00704}. # SMART SM01061 CAT_RBD # SUPFAM SSF50151 SSF50151 # SUPFAM SSF63520 SSF63520; 2 # eggNOG COG3711 LUCA # eggNOG ENOG4105CID Bacteria BLAST swissprot:BGLG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BGLG_ECOLI BioCyc ECOL316407:JW3701-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3701-MONOMER BioCyc EcoCyc:EG10116-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10116-MONOMER COG COG3711 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3711 DIP DIP-9216N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9216N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1016/0092-8674(87)90502-2 http://dx.doi.org/10.1016/0092-8674(87)90502-2 DOI 10.1016/0092-8674(90)90392-R http://dx.doi.org/10.1016/0092-8674(90)90392-R DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.87.13.5074 http://dx.doi.org/10.1073/pnas.87.13.5074 DOI 10.1099/00221287-133-3-563 http://dx.doi.org/10.1099/00221287-133-3-563 DOI 10.1126/science.2200123 http://dx.doi.org/10.1126/science.2200123 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M15746 http://www.ebi.ac.uk/ena/data/view/M15746 EMBL M16487 http://www.ebi.ac.uk/ena/data/view/M16487 EMBL M17098 http://www.ebi.ac.uk/ena/data/view/M17098 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0114 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0114 EcoGene EG10116 http://www.ecogene.org/geneInfo.php?eg_id=EG10116 EnsemblBacteria AAC76746 http://www.ensemblgenomes.org/id/AAC76746 EnsemblBacteria AAC76746 http://www.ensemblgenomes.org/id/AAC76746 EnsemblBacteria BAE77565 http://www.ensemblgenomes.org/id/BAE77565 EnsemblBacteria BAE77565 http://www.ensemblgenomes.org/id/BAE77565 EnsemblBacteria BAE77565 http://www.ensemblgenomes.org/id/BAE77565 EnsemblBacteria b3723 http://www.ensemblgenomes.org/id/b3723 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.1790.10 http://www.cathdb.info/version/latest/superfamily/1.10.1790.10 Gene3D 2.30.24.10 http://www.cathdb.info/version/latest/superfamily/2.30.24.10 GeneID 948235 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948235 HOGENOM HOG000223756 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000223756&db=HOGENOM6 InParanoid P11989 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P11989 IntAct P11989 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P11989* InterPro IPR001550 http://www.ebi.ac.uk/interpro/entry/IPR001550 InterPro IPR004341 http://www.ebi.ac.uk/interpro/entry/IPR004341 InterPro IPR011608 http://www.ebi.ac.uk/interpro/entry/IPR011608 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW3701 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3701 KEGG_Gene eco:b3723 http://www.genome.jp/dbget-bin/www_bget?eco:b3723 KEGG_Orthology KO:K03488 http://www.genome.jp/dbget-bin/www_bget?KO:K03488 MINT MINT-1240048 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1240048 OMA YPDEYAI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YPDEYAI PROSITE PS00654 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00654 PROSITE PS51372 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51372 PSORT swissprot:BGLG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BGLG_ECOLI PSORT-B swissprot:BGLG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BGLG_ECOLI PSORT2 swissprot:BGLG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BGLG_ECOLI Pfam PF00874 http://pfam.xfam.org/family/PF00874 Pfam PF03123 http://pfam.xfam.org/family/PF03123 Phobius swissprot:BGLG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BGLG_ECOLI PhylomeDB P11989 http://phylomedb.org/?seqid=P11989 ProteinModelPortal P11989 http://www.proteinmodelportal.org/query/uniprot/P11989 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1698125 http://www.ncbi.nlm.nih.gov/pubmed/1698125 PubMed 2195546 http://www.ncbi.nlm.nih.gov/pubmed/2195546 PubMed 2200123 http://www.ncbi.nlm.nih.gov/pubmed/2200123 PubMed 3034860 http://www.ncbi.nlm.nih.gov/pubmed/3034860 PubMed 3301003 http://www.ncbi.nlm.nih.gov/pubmed/3301003 PubMed 3309161 http://www.ncbi.nlm.nih.gov/pubmed/3309161 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418179 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418179 RefSeq WP_001295251 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295251 SMART SM01061 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01061 SMR P11989 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P11989 STRING 511145.b3723 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3723&targetmode=cogs STRING COG3711 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3711&targetmode=cogs SUPFAM SSF50151 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50151 SUPFAM SSF63520 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63520 UniProtKB BGLG_ECOLI http://www.uniprot.org/uniprot/BGLG_ECOLI UniProtKB-AC P11989 http://www.uniprot.org/uniprot/P11989 charge swissprot:BGLG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BGLG_ECOLI eggNOG COG3711 http://eggnogapi.embl.de/nog_data/html/tree/COG3711 eggNOG ENOG4105CID http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CID epestfind swissprot:BGLG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BGLG_ECOLI garnier swissprot:BGLG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BGLG_ECOLI helixturnhelix swissprot:BGLG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BGLG_ECOLI hmoment swissprot:BGLG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BGLG_ECOLI iep swissprot:BGLG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BGLG_ECOLI inforesidue swissprot:BGLG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BGLG_ECOLI octanol swissprot:BGLG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BGLG_ECOLI pepcoil swissprot:BGLG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BGLG_ECOLI pepdigest swissprot:BGLG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BGLG_ECOLI pepinfo swissprot:BGLG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BGLG_ECOLI pepnet swissprot:BGLG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BGLG_ECOLI pepstats swissprot:BGLG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BGLG_ECOLI pepwheel swissprot:BGLG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BGLG_ECOLI pepwindow swissprot:BGLG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BGLG_ECOLI sigcleave swissprot:BGLG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BGLG_ECOLI ## Database ID URL or Descriptions # AltName Exodeoxyribonuclease VII large subunit {ECO:0000255|HAMAP-Rule MF_00378} # BRENDA 3.1.11 2026 # BioGrid 4263222 57 # CATALYTIC ACTIVITY Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates. {ECO:0000255|HAMAP-Rule MF_00378}. # CDD cd04489 ExoVII_LU_OBF # EcoGene EG11072 xseA # FUNCTION EX7L_ECOLI Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides. It can also degrade 3' or 5' ss regions extending from the termini of duplex DNA molecules and displaced ss regions. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_component GO:0009318 exodeoxyribonuclease VII complex; IEA:InterPro. # GO_function GO:0003676 nucleic acid binding; IEA:InterPro. # GO_function GO:0008855 exodeoxyribonuclease VII activity; IEA:UniProtKB-HAMAP. # GO_process GO:0006308 DNA catabolic process; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0004518 nuclease activity # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # HAMAP MF_00378 Exonuc_7_L # INTERACTION EX7L_ECOLI P76168 intQ; NbExp=2; IntAct=EBI-559703, EBI-559711; # IntAct P04994 9 # InterPro IPR003753 Exonuc_VII_L # InterPro IPR020579 Exonuc_VII_lsu_C # InterPro IPR025824 OB-fold_nuc-bd_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko03430 Mismatch repair # Organism EX7L_ECOLI Escherichia coli (strain K12) # PATRIC 32120411 VBIEscCol129921_2608 # PIR D65027 NCEC7 # Pfam PF02601 Exonuc_VII_L # Pfam PF13742 tRNA_anti_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Exodeoxyribonuclease 7 large subunit {ECO:0000255|HAMAP-Rule MF_00378} # RefSeq NP_417004 NC_000913.3 # RefSeq WP_000937912 NZ_LN832404.1 # SIMILARITY Belongs to the XseA family. {ECO:0000255|HAMAP- Rule MF_00378}. # SUBCELLULAR LOCATION EX7L_ECOLI Cytoplasm. # SUBUNIT Heterooligomer composed of two different subunits with an approximate ratio of 4 small subunits for 1 large. {ECO:0000269|PubMed 6284744}. # TIGRFAMs TIGR00237 xseA # eggNOG COG1570 LUCA # eggNOG ENOG4105DVS Bacteria BLAST swissprot:EX7L_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EX7L_ECOLI BioCyc ECOL316407:JW2493-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2493-MONOMER BioCyc EcoCyc:EG11072-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11072-MONOMER BioCyc MetaCyc:EG11072-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11072-MONOMER COG COG1570 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1570 DIP DIP-11146N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11146N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378} http://www.genome.jp/dbget-bin/www_bget?EC:3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J02599 http://www.ebi.ac.uk/ena/data/view/J02599 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378} http://enzyme.expasy.org/EC/3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378} EchoBASE EB1065 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1065 EcoGene EG11072 http://www.ecogene.org/geneInfo.php?eg_id=EG11072 EnsemblBacteria AAC75562 http://www.ensemblgenomes.org/id/AAC75562 EnsemblBacteria AAC75562 http://www.ensemblgenomes.org/id/AAC75562 EnsemblBacteria BAA16396 http://www.ensemblgenomes.org/id/BAA16396 EnsemblBacteria BAA16396 http://www.ensemblgenomes.org/id/BAA16396 EnsemblBacteria BAA16396 http://www.ensemblgenomes.org/id/BAA16396 EnsemblBacteria b2509 http://www.ensemblgenomes.org/id/b2509 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0009318 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009318 GO_function GO:0003676 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003676 GO_function GO:0008855 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008855 GO_process GO:0006308 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006308 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 GeneID 946988 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946988 HAMAP MF_00378 http://hamap.expasy.org/unirule/MF_00378 HOGENOM HOG000229265 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000229265&db=HOGENOM6 InParanoid P04994 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P04994 IntAct P04994 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P04994* IntEnz 3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.11.6 {ECO:0000255|HAMAP-Rule:MF_00378} InterPro IPR003753 http://www.ebi.ac.uk/interpro/entry/IPR003753 InterPro IPR020579 http://www.ebi.ac.uk/interpro/entry/IPR020579 InterPro IPR025824 http://www.ebi.ac.uk/interpro/entry/IPR025824 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW2493 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2493 KEGG_Gene eco:b2509 http://www.genome.jp/dbget-bin/www_bget?eco:b2509 KEGG_Orthology KO:K03601 http://www.genome.jp/dbget-bin/www_bget?KO:K03601 KEGG_Pathway ko03430 http://www.genome.jp/kegg-bin/show_pathway?ko03430 MINT MINT-1272208 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1272208 OMA ENAQVRC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ENAQVRC PSORT swissprot:EX7L_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EX7L_ECOLI PSORT-B swissprot:EX7L_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EX7L_ECOLI PSORT2 swissprot:EX7L_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EX7L_ECOLI Pfam PF02601 http://pfam.xfam.org/family/PF02601 Pfam PF13742 http://pfam.xfam.org/family/PF13742 Phobius swissprot:EX7L_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EX7L_ECOLI PhylomeDB P04994 http://phylomedb.org/?seqid=P04994 ProteinModelPortal P04994 http://www.proteinmodelportal.org/query/uniprot/P04994 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3021756 http://www.ncbi.nlm.nih.gov/pubmed/3021756 PubMed 6284744 http://www.ncbi.nlm.nih.gov/pubmed/6284744 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417004 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417004 RefSeq WP_000937912 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000937912 SMR P04994 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P04994 STRING 511145.b2509 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2509&targetmode=cogs STRING COG1570 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1570&targetmode=cogs TIGRFAMs TIGR00237 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00237 UniProtKB EX7L_ECOLI http://www.uniprot.org/uniprot/EX7L_ECOLI UniProtKB-AC P04994 http://www.uniprot.org/uniprot/P04994 charge swissprot:EX7L_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EX7L_ECOLI eggNOG COG1570 http://eggnogapi.embl.de/nog_data/html/tree/COG1570 eggNOG ENOG4105DVS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DVS epestfind swissprot:EX7L_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EX7L_ECOLI garnier swissprot:EX7L_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EX7L_ECOLI helixturnhelix swissprot:EX7L_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EX7L_ECOLI hmoment swissprot:EX7L_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EX7L_ECOLI iep swissprot:EX7L_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EX7L_ECOLI inforesidue swissprot:EX7L_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EX7L_ECOLI octanol swissprot:EX7L_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EX7L_ECOLI pepcoil swissprot:EX7L_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EX7L_ECOLI pepdigest swissprot:EX7L_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EX7L_ECOLI pepinfo swissprot:EX7L_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EX7L_ECOLI pepnet swissprot:EX7L_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EX7L_ECOLI pepstats swissprot:EX7L_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EX7L_ECOLI pepwheel swissprot:EX7L_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EX7L_ECOLI pepwindow swissprot:EX7L_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EX7L_ECOLI sigcleave swissprot:EX7L_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EX7L_ECOLI ## Database ID URL or Descriptions # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG13384 yeeP # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0003924 GTPase activity; IBA:GO_Central. # GO_function GO:0005525 GTP binding; IBA:GO_Central. # GO_function GO:0043022 ribosome binding; IBA:GO_Central. # GO_process GO:0000027 ribosomal large subunit assembly; IBA:GO_Central. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003924 GTPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0022618 ribonucleoprotein complex assembly # Gene3D 3.40.50.300 -; 1. # InterPro IPR027417 P-loop_NTPase # Organism YEEP_ECOLI Escherichia coli (strain K12) # PIR F64964 F64964 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEEP_ECOLI Putative uncharacterized protein YeeP # RefSeq WP_014639038 NZ_LN832404.1 # SIMILARITY To E.coli YfjP and YkfA. {ECO 0000305}. # SUPFAM SSF52540 SSF52540 BLAST swissprot:YEEP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEEP_ECOLI BioCyc EcoCyc:G7079-MONOMER http://biocyc.org/getid?id=EcoCyc:G7079-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3165 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3165 EcoGene EG13384 http://www.ecogene.org/geneInfo.php?eg_id=EG13384 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_function GO:0043022 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043022 GO_process GO:0000027 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000027 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0022618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022618 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 HOGENOM HOG000121786 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000121786&db=HOGENOM6 InParanoid P76359 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76359 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 OMA DEYFWRY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DEYFWRY PSORT swissprot:YEEP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEEP_ECOLI PSORT-B swissprot:YEEP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEEP_ECOLI PSORT2 swissprot:YEEP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEEP_ECOLI Phobius swissprot:YEEP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEEP_ECOLI ProteinModelPortal P76359 http://www.proteinmodelportal.org/query/uniprot/P76359 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_014639038 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_014639038 SMR P76359 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76359 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB YEEP_ECOLI http://www.uniprot.org/uniprot/YEEP_ECOLI UniProtKB-AC P76359 http://www.uniprot.org/uniprot/P76359 charge swissprot:YEEP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEEP_ECOLI epestfind swissprot:YEEP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEEP_ECOLI garnier swissprot:YEEP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEEP_ECOLI helixturnhelix swissprot:YEEP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEEP_ECOLI hmoment swissprot:YEEP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEEP_ECOLI iep swissprot:YEEP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEEP_ECOLI inforesidue swissprot:YEEP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEEP_ECOLI octanol swissprot:YEEP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEEP_ECOLI pepcoil swissprot:YEEP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEEP_ECOLI pepdigest swissprot:YEEP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEEP_ECOLI pepinfo swissprot:YEEP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEEP_ECOLI pepnet swissprot:YEEP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEEP_ECOLI pepstats swissprot:YEEP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEEP_ECOLI pepwheel swissprot:YEEP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEEP_ECOLI pepwindow swissprot:YEEP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEEP_ECOLI sigcleave swissprot:YEEP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEEP_ECOLI ## Database ID URL or Descriptions # BioGrid 4260442 108 # EcoGene EG12002 yehP # Gene3D 3.40.50.410 -; 1. # InterPro IPR002035 VWF_A # InterPro IPR008912 Uncharacterised_CoxE # Organism YEHP_ECOLI Escherichia coli (strain K12) # PATRIC 32119577 VBIEscCol129921_2199 # PIR H64979 H64979 # Pfam PF05762 VWA_CoxE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEHP_ECOLI Uncharacterized protein YehP # RefSeq NP_416625 NC_000913.3 # RefSeq WP_001333512 NZ_LN832404.1 # SMART SM00327 VWA # SUPFAM SSF53300 SSF53300 # eggNOG ENOG4105DEG Bacteria # eggNOG ENOG410XPUJ LUCA BLAST swissprot:YEHP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEHP_ECOLI BioCyc ECOL316407:JW5350-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5350-MONOMER BioCyc EcoCyc:EG12002-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12002-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1940 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1940 EcoGene EG12002 http://www.ecogene.org/geneInfo.php?eg_id=EG12002 EnsemblBacteria AAC75182 http://www.ensemblgenomes.org/id/AAC75182 EnsemblBacteria AAC75182 http://www.ensemblgenomes.org/id/AAC75182 EnsemblBacteria BAE76597 http://www.ensemblgenomes.org/id/BAE76597 EnsemblBacteria BAE76597 http://www.ensemblgenomes.org/id/BAE76597 EnsemblBacteria BAE76597 http://www.ensemblgenomes.org/id/BAE76597 EnsemblBacteria b2121 http://www.ensemblgenomes.org/id/b2121 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.40.50.410 http://www.cathdb.info/version/latest/superfamily/3.40.50.410 GeneID 946652 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946652 HOGENOM HOG000122199 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122199&db=HOGENOM6 InParanoid P33352 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33352 InterPro IPR002035 http://www.ebi.ac.uk/interpro/entry/IPR002035 InterPro IPR008912 http://www.ebi.ac.uk/interpro/entry/IPR008912 KEGG_Gene ecj:JW5350 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5350 KEGG_Gene eco:b2121 http://www.genome.jp/dbget-bin/www_bget?eco:b2121 OMA GAPAYDR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GAPAYDR PSORT swissprot:YEHP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEHP_ECOLI PSORT-B swissprot:YEHP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEHP_ECOLI PSORT2 swissprot:YEHP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEHP_ECOLI Pfam PF05762 http://pfam.xfam.org/family/PF05762 Phobius swissprot:YEHP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEHP_ECOLI PhylomeDB P33352 http://phylomedb.org/?seqid=P33352 ProteinModelPortal P33352 http://www.proteinmodelportal.org/query/uniprot/P33352 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416625 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416625 RefSeq WP_001333512 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001333512 SMART SM00327 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00327 SMR P33352 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33352 STRING 511145.b2121 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2121&targetmode=cogs SUPFAM SSF53300 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53300 UniProtKB YEHP_ECOLI http://www.uniprot.org/uniprot/YEHP_ECOLI UniProtKB-AC P33352 http://www.uniprot.org/uniprot/P33352 charge swissprot:YEHP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEHP_ECOLI eggNOG ENOG4105DEG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DEG eggNOG ENOG410XPUJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPUJ epestfind swissprot:YEHP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEHP_ECOLI garnier swissprot:YEHP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEHP_ECOLI helixturnhelix swissprot:YEHP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEHP_ECOLI hmoment swissprot:YEHP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEHP_ECOLI iep swissprot:YEHP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEHP_ECOLI inforesidue swissprot:YEHP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEHP_ECOLI octanol swissprot:YEHP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEHP_ECOLI pepcoil swissprot:YEHP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEHP_ECOLI pepdigest swissprot:YEHP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEHP_ECOLI pepinfo swissprot:YEHP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEHP_ECOLI pepnet swissprot:YEHP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEHP_ECOLI pepstats swissprot:YEHP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEHP_ECOLI pepwheel swissprot:YEHP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEHP_ECOLI pepwindow swissprot:YEHP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEHP_ECOLI sigcleave swissprot:YEHP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEHP_ECOLI ## Database ID URL or Descriptions # AltName Sigma-70 {ECO:0000255|HAMAP-Rule MF_00963} # BioGrid 4261068 180 # DOMAIN RPOD_ECOLI Contains 4 domains, connected by flexible linkers. In the active conformation, the domains are in an extended conformation, each making extensive interactions with the RNA polymerase catalytic core. # DOMAIN RPOD_ECOLI In the autoinhibited state, sigma-70 factor domain-1 packs closely together with sigma-70 factor domains-2 and -4, contrary to the extended conformation that is seen when the protein is part of the RNA polymerase holoenzyme. {ECO 0000305}. # DOMAIN RPOD_ECOLI The sigma-70 factor domain-2 mediates sequence-specific interaction with the -10 element in promoter DNA, and plays an important role in melting the double-stranded DNA and the formation of the transcription bubble. The sigma-70 factor domain- 2 mediates interaction with the RNA polymerase subunits RpoB and RpoC. # DOMAIN RPOD_ECOLI The sigma-70 factor domain-4 contains a helix-turn-helix (H-T-H) motif that mediates interaction with the -35 element in promoter DNA. The domain also mediates interaction with the RNA polymerase subunit RpoA. Interactions between sigma-70 factor domain-4 and anti-sigma factors prevents interaction of sigma factors with the RNA polymerase catalytic core (PubMed 19903881 and PubMed 21829166). This domain is probably also responsible for interaction with Crp (PubMed 10860740). {ECO 0000269|PubMed 10860740}. # EcoGene EG10896 rpoD # FUNCTION RPOD_ECOLI Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. Preferentially transcribes genes associated with fast growth, such as ribosomal operons, other protein-synthesis related genes, rRNA- and tRNA-encoding genes and prfB. {ECO 0000255|HAMAP-Rule MF_00963, ECO 0000269|PubMed 1643661, ECO 0000269|PubMed 1745227, ECO 0000269|PubMed 21398637, ECO 0000269|PubMed 3543015, ECO 0000269|PubMed 8289270, ECO 0000269|PubMed 8808934}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_function GO:0016987 sigma factor activity; IDA:EcoliWiki. # GO_process GO:0001123 transcription initiation from bacterial-type RNA polymerase promoter; IEA:UniProtKB-HAMAP. # GO_process GO:0009408 response to heat; IEP:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0000988 transcription factor activity, protein binding # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 2. # HAMAP MF_00963 Sigma70_RpoD_SigA # INTERACTION RPOD_ECOLI P32267 asiA (xeno); NbExp=5; IntAct=EBI-545104, EBI-2124737; P0A8T7 rpoC; NbExp=8; IntAct=EBI-545104, EBI-543604; P0AFX4 rsd; NbExp=11; IntAct=EBI-545104, EBI-1134364; # IntAct P00579 56 # InterPro IPR000943 RNA_pol_sigma70 # InterPro IPR007127 RNA_pol_sigma_70_r1_1 # InterPro IPR007624 RNA_pol_sigma70_r3 # InterPro IPR007627 RNA_pol_sigma70_r2 # InterPro IPR007630 RNA_pol_sigma70_r4 # InterPro IPR007631 RNA_pol_sigma_70_non-ess # InterPro IPR009042 RNA_pol_sigma70_r1_2 # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR012760 RNA_pol_sigma_RpoD_C # InterPro IPR013324 RNA_pol_sigma_r3_r4 # InterPro IPR013325 RNA_pol_sigma_r2 # InterPro IPR014284 RNA_pol_sigma-70_dom # InterPro IPR028630 Sigma70_RpoD # KEGG_Brite ko03021 Transcription machinery # Organism RPOD_ECOLI Escherichia coli (strain K12) # PATRIC 32121550 VBIEscCol129921_3162 # PDB 1SIG X-ray; 2.60 A; A=114-448 # PDB 1TLH NMR; -; B=533-613 # PDB 2P7V X-ray; 2.60 A; B=546-613 # PDB 3IYD EM; 19.8 A; F=1-613 # PDB 3T72 X-ray; 4.33 A; o/q=533-609 # PDB 4JK1 X-ray; 3.90 A; X/Y=1-613 # PDB 4JK2 X-ray; 4.20 A; X/Y=1-613 # PDB 4JKR X-ray; 4.20 A; F/L=1-613 # PDB 4KMU X-ray; 3.85 A; X/Y=1-613 # PDB 4KN4 X-ray; 3.96 A; X/Y=1-613 # PDB 4KN7 X-ray; 3.69 A; X/Y=1-613 # PDB 4LJZ X-ray; 3.59 A; F/L=92-613 # PDB 4LK0 X-ray; 3.91 A; F/L=92-613 # PDB 4LK1 X-ray; 3.84 A; F/L=1-613 # PDB 4LLG X-ray; 3.79 A; F/L=1-613 # PDB 4MEX X-ray; 3.90 A; F/L=1-613 # PDB 4MEY X-ray; 3.95 A; F/L=1-613 # PDB 4XSX X-ray; 3.71 A; F/L=92-613 # PDB 4XSY X-ray; 4.01 A; F/L=92-613 # PDB 4XSZ X-ray; 3.68 A; F/L=92-613 # PDB 4YFK X-ray; 3.57 A; F/L=1-613 # PDB 4YFN X-ray; 3.82 A; F/L=1-613 # PDB 4YFX X-ray; 3.84 A; F/L=1-613 # PDB 4YG2 X-ray; 3.70 A; F/L=1-613 # PDB 4YLN X-ray; 5.50 A; F/L/R=1-613 # PDB 4YLO X-ray; 6.00 A; F/L/R=1-613 # PDB 4YLP X-ray; 5.50 A; F/L/R=1-613 # PDB 4ZH2 X-ray; 4.20 A; F/L=1-613 # PDB 4ZH3 X-ray; 4.08 A; F/L=1-613 # PDB 4ZH4 X-ray; 3.99 A; F/L=1-613 # PIR A65095 RNECS # PRINTS PR00046 SIGMA70FCT # PROSITE PS00715 SIGMA70_1 # PROSITE PS00716 SIGMA70_2 # Pfam PF00140 Sigma70_r1_2 # Pfam PF03979 Sigma70_r1_1 # Pfam PF04539 Sigma70_r3 # Pfam PF04542 Sigma70_r2 # Pfam PF04545 Sigma70_r4 # Pfam PF04546 Sigma70_ner # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RNA polymerase sigma factor RpoD {ECO:0000255|HAMAP-Rule MF_00963} # RefSeq NP_417539 NC_000913.3 # RefSeq WP_000437376 NZ_LN832404.1 # SIMILARITY Belongs to the sigma-70 factor family. RpoD/SigA subfamily. {ECO:0000255|HAMAP-Rule MF_00963}. # SUBCELLULAR LOCATION RPOD_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00963}. # SUBUNIT RPOD_ECOLI Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription. Identified in a complex containing RpoD, the RNA polymerase subunits RpoA, RpoB and RpoZ, CRP and DNA. Interacts with Rsd; this prevents interaction with the RNA polymerase catalytic core and with promoter DNA, and as a consequence, promotes transcription from promoters that require alternative sigma factors. Interacts with phage T4 AsiA; this interferes with binding to DNA and to the RNA polymerase. {ECO 0000255|HAMAP-Rule MF_00963, ECO 0000269|PubMed 15257291, ECO 0000269|PubMed 17681541, ECO 0000269|PubMed 19903881, ECO 0000269|PubMed 21829166, ECO 0000269|PubMed 23389035}. # SUPFAM SSF88659 SSF88659; 2 # SUPFAM SSF88946 SSF88946 # TIGRFAMs TIGR02393 RpoD_Cterm # TIGRFAMs TIGR02937 sigma70-ECF # eggNOG COG0568 LUCA # eggNOG ENOG4105DG1 Bacteria BLAST swissprot:RPOD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RPOD_ECOLI BioCyc ECOL316407:JW3039-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3039-MONOMER BioCyc EcoCyc:RPOD-MONOMER http://biocyc.org/getid?id=EcoCyc:RPOD-MONOMER BioCyc MetaCyc:RPOD-MONOMER http://biocyc.org/getid?id=MetaCyc:RPOD-MONOMER COG COG0568 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0568 DIP DIP-10773N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10773N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/jmbi.1994.1001 http://dx.doi.org/10.1006/jmbi.1994.1001 DOI 10.1006/jmbi.2000.3737 http://dx.doi.org/10.1006/jmbi.2000.3737 DOI 10.1007/BF00290644 http://dx.doi.org/10.1007/BF00290644 DOI 10.1016/0014-5793(75)81001-5 http://dx.doi.org/10.1016/0014-5793(75)81001-5 DOI 10.1016/0092-8674(92)90174-B http://dx.doi.org/10.1016/0092-8674(92)90174-B DOI 10.1016/S0092-8674(00)81329-X http://dx.doi.org/10.1016/S0092-8674(00)81329-X DOI 10.1016/j.jmb.2007.06.081 http://dx.doi.org/10.1016/j.jmb.2007.06.081 DOI 10.1038/emboj.2011.271 http://dx.doi.org/10.1038/emboj.2011.271 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/sj.emboj.7600312 http://dx.doi.org/10.1038/sj.emboj.7600312 DOI 10.1073/pnas.0908782106 http://dx.doi.org/10.1073/pnas.0908782106 DOI 10.1074/jbc.M112.430900 http://dx.doi.org/10.1074/jbc.M112.430900 DOI 10.1093/nar/9.12.2889 http://dx.doi.org/10.1093/nar/9.12.2889 DOI 10.1093/nar/gkr129 http://dx.doi.org/10.1093/nar/gkr129 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01687 http://www.ebi.ac.uk/ena/data/view/J01687 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28379 http://www.ebi.ac.uk/ena/data/view/U28379 EchoBASE EB0889 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0889 EcoGene EG10896 http://www.ecogene.org/geneInfo.php?eg_id=EG10896 EnsemblBacteria AAC76103 http://www.ensemblgenomes.org/id/AAC76103 EnsemblBacteria AAC76103 http://www.ensemblgenomes.org/id/AAC76103 EnsemblBacteria BAE77118 http://www.ensemblgenomes.org/id/BAE77118 EnsemblBacteria BAE77118 http://www.ensemblgenomes.org/id/BAE77118 EnsemblBacteria BAE77118 http://www.ensemblgenomes.org/id/BAE77118 EnsemblBacteria b3067 http://www.ensemblgenomes.org/id/b3067 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0016987 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016987 GO_process GO:0001123 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001123 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0000988 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000988 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 947567 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947567 HAMAP MF_00963 http://hamap.expasy.org/unirule/MF_00963 HOGENOM HOG000270272 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000270272&db=HOGENOM6 InParanoid P00579 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00579 IntAct P00579 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00579* InterPro IPR000943 http://www.ebi.ac.uk/interpro/entry/IPR000943 InterPro IPR007127 http://www.ebi.ac.uk/interpro/entry/IPR007127 InterPro IPR007624 http://www.ebi.ac.uk/interpro/entry/IPR007624 InterPro IPR007627 http://www.ebi.ac.uk/interpro/entry/IPR007627 InterPro IPR007630 http://www.ebi.ac.uk/interpro/entry/IPR007630 InterPro IPR007631 http://www.ebi.ac.uk/interpro/entry/IPR007631 InterPro IPR009042 http://www.ebi.ac.uk/interpro/entry/IPR009042 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR012760 http://www.ebi.ac.uk/interpro/entry/IPR012760 InterPro IPR013324 http://www.ebi.ac.uk/interpro/entry/IPR013324 InterPro IPR013325 http://www.ebi.ac.uk/interpro/entry/IPR013325 InterPro IPR014284 http://www.ebi.ac.uk/interpro/entry/IPR014284 InterPro IPR028630 http://www.ebi.ac.uk/interpro/entry/IPR028630 KEGG_Brite ko03021 http://www.genome.jp/dbget-bin/www_bget?ko03021 KEGG_Gene ecj:JW3039 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3039 KEGG_Gene eco:b3067 http://www.genome.jp/dbget-bin/www_bget?eco:b3067 KEGG_Orthology KO:K03086 http://www.genome.jp/dbget-bin/www_bget?KO:K03086 MINT MINT-1220595 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1220595 OMA RDAKKEM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RDAKKEM PDB 1SIG http://www.ebi.ac.uk/pdbe-srv/view/entry/1SIG PDB 1TLH http://www.ebi.ac.uk/pdbe-srv/view/entry/1TLH PDB 2P7V http://www.ebi.ac.uk/pdbe-srv/view/entry/2P7V PDB 3IYD http://www.ebi.ac.uk/pdbe-srv/view/entry/3IYD PDB 3T72 http://www.ebi.ac.uk/pdbe-srv/view/entry/3T72 PDB 4JK1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4JK1 PDB 4JK2 http://www.ebi.ac.uk/pdbe-srv/view/entry/4JK2 PDB 4JKR http://www.ebi.ac.uk/pdbe-srv/view/entry/4JKR PDB 4KMU http://www.ebi.ac.uk/pdbe-srv/view/entry/4KMU PDB 4KN4 http://www.ebi.ac.uk/pdbe-srv/view/entry/4KN4 PDB 4KN7 http://www.ebi.ac.uk/pdbe-srv/view/entry/4KN7 PDB 4LJZ http://www.ebi.ac.uk/pdbe-srv/view/entry/4LJZ PDB 4LK0 http://www.ebi.ac.uk/pdbe-srv/view/entry/4LK0 PDB 4LK1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4LK1 PDB 4LLG http://www.ebi.ac.uk/pdbe-srv/view/entry/4LLG PDB 4MEX http://www.ebi.ac.uk/pdbe-srv/view/entry/4MEX PDB 4MEY http://www.ebi.ac.uk/pdbe-srv/view/entry/4MEY PDB 4XSX http://www.ebi.ac.uk/pdbe-srv/view/entry/4XSX PDB 4XSY http://www.ebi.ac.uk/pdbe-srv/view/entry/4XSY PDB 4XSZ http://www.ebi.ac.uk/pdbe-srv/view/entry/4XSZ PDB 4YFK http://www.ebi.ac.uk/pdbe-srv/view/entry/4YFK PDB 4YFN http://www.ebi.ac.uk/pdbe-srv/view/entry/4YFN PDB 4YFX http://www.ebi.ac.uk/pdbe-srv/view/entry/4YFX PDB 4YG2 http://www.ebi.ac.uk/pdbe-srv/view/entry/4YG2 PDB 4YLN http://www.ebi.ac.uk/pdbe-srv/view/entry/4YLN PDB 4YLO http://www.ebi.ac.uk/pdbe-srv/view/entry/4YLO PDB 4YLP http://www.ebi.ac.uk/pdbe-srv/view/entry/4YLP PDB 4ZH2 http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZH2 PDB 4ZH3 http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZH3 PDB 4ZH4 http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZH4 PDBsum 1SIG http://www.ebi.ac.uk/pdbsum/1SIG PDBsum 1TLH http://www.ebi.ac.uk/pdbsum/1TLH PDBsum 2P7V http://www.ebi.ac.uk/pdbsum/2P7V PDBsum 3IYD http://www.ebi.ac.uk/pdbsum/3IYD PDBsum 3T72 http://www.ebi.ac.uk/pdbsum/3T72 PDBsum 4JK1 http://www.ebi.ac.uk/pdbsum/4JK1 PDBsum 4JK2 http://www.ebi.ac.uk/pdbsum/4JK2 PDBsum 4JKR http://www.ebi.ac.uk/pdbsum/4JKR PDBsum 4KMU http://www.ebi.ac.uk/pdbsum/4KMU PDBsum 4KN4 http://www.ebi.ac.uk/pdbsum/4KN4 PDBsum 4KN7 http://www.ebi.ac.uk/pdbsum/4KN7 PDBsum 4LJZ http://www.ebi.ac.uk/pdbsum/4LJZ PDBsum 4LK0 http://www.ebi.ac.uk/pdbsum/4LK0 PDBsum 4LK1 http://www.ebi.ac.uk/pdbsum/4LK1 PDBsum 4LLG http://www.ebi.ac.uk/pdbsum/4LLG PDBsum 4MEX http://www.ebi.ac.uk/pdbsum/4MEX PDBsum 4MEY http://www.ebi.ac.uk/pdbsum/4MEY PDBsum 4XSX http://www.ebi.ac.uk/pdbsum/4XSX PDBsum 4XSY http://www.ebi.ac.uk/pdbsum/4XSY PDBsum 4XSZ http://www.ebi.ac.uk/pdbsum/4XSZ PDBsum 4YFK http://www.ebi.ac.uk/pdbsum/4YFK PDBsum 4YFN http://www.ebi.ac.uk/pdbsum/4YFN PDBsum 4YFX http://www.ebi.ac.uk/pdbsum/4YFX PDBsum 4YG2 http://www.ebi.ac.uk/pdbsum/4YG2 PDBsum 4YLN http://www.ebi.ac.uk/pdbsum/4YLN PDBsum 4YLO http://www.ebi.ac.uk/pdbsum/4YLO PDBsum 4YLP http://www.ebi.ac.uk/pdbsum/4YLP PDBsum 4ZH2 http://www.ebi.ac.uk/pdbsum/4ZH2 PDBsum 4ZH3 http://www.ebi.ac.uk/pdbsum/4ZH3 PDBsum 4ZH4 http://www.ebi.ac.uk/pdbsum/4ZH4 PRINTS PR00046 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00046 PROSITE PS00715 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00715 PROSITE PS00716 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00716 PSORT swissprot:RPOD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RPOD_ECOLI PSORT-B swissprot:RPOD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RPOD_ECOLI PSORT2 swissprot:RPOD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RPOD_ECOLI Pfam PF00140 http://pfam.xfam.org/family/PF00140 Pfam PF03979 http://pfam.xfam.org/family/PF03979 Pfam PF04539 http://pfam.xfam.org/family/PF04539 Pfam PF04542 http://pfam.xfam.org/family/PF04542 Pfam PF04545 http://pfam.xfam.org/family/PF04545 Pfam PF04546 http://pfam.xfam.org/family/PF04546 Phobius swissprot:RPOD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RPOD_ECOLI PhylomeDB P00579 http://phylomedb.org/?seqid=P00579 ProteinModelPortal P00579 http://www.proteinmodelportal.org/query/uniprot/P00579 PubMed 10860740 http://www.ncbi.nlm.nih.gov/pubmed/10860740 PubMed 1095419 http://www.ncbi.nlm.nih.gov/pubmed/1095419 PubMed 15257291 http://www.ncbi.nlm.nih.gov/pubmed/15257291 PubMed 1643661 http://www.ncbi.nlm.nih.gov/pubmed/1643661 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1745227 http://www.ncbi.nlm.nih.gov/pubmed/1745227 PubMed 17681541 http://www.ncbi.nlm.nih.gov/pubmed/17681541 PubMed 19903881 http://www.ncbi.nlm.nih.gov/pubmed/19903881 PubMed 21398637 http://www.ncbi.nlm.nih.gov/pubmed/21398637 PubMed 21829166 http://www.ncbi.nlm.nih.gov/pubmed/21829166 PubMed 23389035 http://www.ncbi.nlm.nih.gov/pubmed/23389035 PubMed 3543015 http://www.ncbi.nlm.nih.gov/pubmed/3543015 PubMed 6269063 http://www.ncbi.nlm.nih.gov/pubmed/6269063 PubMed 8289270 http://www.ncbi.nlm.nih.gov/pubmed/8289270 PubMed 8808934 http://www.ncbi.nlm.nih.gov/pubmed/8808934 PubMed 8858155 http://www.ncbi.nlm.nih.gov/pubmed/8858155 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417539 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417539 RefSeq WP_000437376 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000437376 SMR P00579 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00579 STRING 511145.b3067 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3067&targetmode=cogs STRING COG0568 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0568&targetmode=cogs SUPFAM SSF88659 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF88659 SUPFAM SSF88946 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF88946 TIGRFAMs TIGR02393 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02393 TIGRFAMs TIGR02937 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02937 UniProtKB RPOD_ECOLI http://www.uniprot.org/uniprot/RPOD_ECOLI UniProtKB-AC P00579 http://www.uniprot.org/uniprot/P00579 charge swissprot:RPOD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RPOD_ECOLI eggNOG COG0568 http://eggnogapi.embl.de/nog_data/html/tree/COG0568 eggNOG ENOG4105DG1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DG1 epestfind swissprot:RPOD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RPOD_ECOLI garnier swissprot:RPOD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RPOD_ECOLI helixturnhelix swissprot:RPOD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RPOD_ECOLI hmoment swissprot:RPOD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RPOD_ECOLI iep swissprot:RPOD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RPOD_ECOLI inforesidue swissprot:RPOD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RPOD_ECOLI octanol swissprot:RPOD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RPOD_ECOLI pepcoil swissprot:RPOD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RPOD_ECOLI pepdigest swissprot:RPOD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RPOD_ECOLI pepinfo swissprot:RPOD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RPOD_ECOLI pepnet swissprot:RPOD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RPOD_ECOLI pepstats swissprot:RPOD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RPOD_ECOLI pepwheel swissprot:RPOD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RPOD_ECOLI pepwindow swissprot:RPOD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RPOD_ECOLI sigcleave swissprot:RPOD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RPOD_ECOLI ## Database ID URL or Descriptions # BioGrid 4259822 256 # CAZy GT2 Glycosyltransferase Family 2 # EcoGene EG13298 yaiP # GO_function GO:0016740 transferase activity; IBA:GO_Central. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006950 response to stress # Gene3D 3.90.550.10 -; 1. # IntAct Q47536 3 # InterPro IPR001173 Glyco_trans_2-like # InterPro IPR029044 Nucleotide-diphossugar_trans # Organism YAIP_ECOLI Escherichia coli (strain K12) # PATRIC 32115863 VBIEscCol129921_0373 # PIR C64764 C64764 # Pfam PF00535 Glycos_transf_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAIP_ECOLI Uncharacterized protein YaiP # RefSeq NP_414897 NC_000913.3 # RefSeq WP_000860444 NZ_LN832404.1 # SUPFAM SSF53448 SSF53448 # TCDB 4.D.1.1.11 the putative vectorial glycosyl polymerization (vgp) family # eggNOG COG1215 LUCA # eggNOG ENOG4108PBI Bacteria BLAST swissprot:YAIP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAIP_ECOLI BioCyc ECOL316407:JW0355-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0355-MONOMER BioCyc EcoCyc:G6215-MONOMER http://biocyc.org/getid?id=EcoCyc:G6215-MONOMER DIP DIP-11277N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11277N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D85613 http://www.ebi.ac.uk/ena/data/view/D85613 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB3083 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3083 EcoGene EG13298 http://www.ecogene.org/geneInfo.php?eg_id=EG13298 EnsemblBacteria AAC73466 http://www.ensemblgenomes.org/id/AAC73466 EnsemblBacteria AAC73466 http://www.ensemblgenomes.org/id/AAC73466 EnsemblBacteria BAE76144 http://www.ensemblgenomes.org/id/BAE76144 EnsemblBacteria BAE76144 http://www.ensemblgenomes.org/id/BAE76144 EnsemblBacteria BAE76144 http://www.ensemblgenomes.org/id/BAE76144 EnsemblBacteria b0363 http://www.ensemblgenomes.org/id/b0363 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016740 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016740 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.90.550.10 http://www.cathdb.info/version/latest/superfamily/3.90.550.10 GeneID 945308 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945308 HOGENOM HOG000117434 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117434&db=HOGENOM6 InParanoid Q47536 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q47536 IntAct Q47536 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q47536* InterPro IPR001173 http://www.ebi.ac.uk/interpro/entry/IPR001173 InterPro IPR029044 http://www.ebi.ac.uk/interpro/entry/IPR029044 KEGG_Gene ecj:JW0355 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0355 KEGG_Gene eco:b0363 http://www.genome.jp/dbget-bin/www_bget?eco:b0363 MINT MINT-1257312 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1257312 OMA EILAITI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EILAITI PSORT swissprot:YAIP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAIP_ECOLI PSORT-B swissprot:YAIP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAIP_ECOLI PSORT2 swissprot:YAIP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAIP_ECOLI Pfam PF00535 http://pfam.xfam.org/family/PF00535 Phobius swissprot:YAIP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAIP_ECOLI PhylomeDB Q47536 http://phylomedb.org/?seqid=Q47536 ProteinModelPortal Q47536 http://www.proteinmodelportal.org/query/uniprot/Q47536 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414897 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414897 RefSeq WP_000860444 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000860444 STRING 511145.b0363 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0363&targetmode=cogs SUPFAM SSF53448 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53448 TCDB 4.D.1.1.11 http://www.tcdb.org/search/result.php?tc=4.D.1.1.11 UniProtKB YAIP_ECOLI http://www.uniprot.org/uniprot/YAIP_ECOLI UniProtKB-AC Q47536 http://www.uniprot.org/uniprot/Q47536 charge swissprot:YAIP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAIP_ECOLI eggNOG COG1215 http://eggnogapi.embl.de/nog_data/html/tree/COG1215 eggNOG ENOG4108PBI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108PBI epestfind swissprot:YAIP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAIP_ECOLI garnier swissprot:YAIP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAIP_ECOLI helixturnhelix swissprot:YAIP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAIP_ECOLI hmoment swissprot:YAIP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAIP_ECOLI iep swissprot:YAIP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAIP_ECOLI inforesidue swissprot:YAIP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAIP_ECOLI octanol swissprot:YAIP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAIP_ECOLI pepcoil swissprot:YAIP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAIP_ECOLI pepdigest swissprot:YAIP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAIP_ECOLI pepinfo swissprot:YAIP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAIP_ECOLI pepnet swissprot:YAIP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAIP_ECOLI pepstats swissprot:YAIP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAIP_ECOLI pepwheel swissprot:YAIP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAIP_ECOLI pepwindow swissprot:YAIP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAIP_ECOLI sigcleave swissprot:YAIP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAIP_ECOLI ## Database ID URL or Descriptions # AltName YAGH_ECOLI 1,4-beta-D-xylan xylohydrolase # AltName YAGH_ECOLI Xylan 1,4-beta-xylosidase # BioGrid 4261986 9 # CATALYTIC ACTIVITY YAGH_ECOLI Hydrolysis of (1->4)-beta-D-xylans, to remove successive D-xylose residues from the non-reducing termini. # CAZy GH43 Glycoside Hydrolase Family 43 # EcoGene EG13347 yagH # GO_function GO:0009044 xylan 1,4-beta-xylosidase activity; IEA:UniProtKB-EC. # GO_process GO:0045493 xylan catabolic process; IEA:UniProtKB-KW. # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # Gene3D 2.115.10.20 -; 1. # Gene3D 2.60.120.200 -; 1. # IntAct P77713 5 # InterPro IPR006710 Glyco_hydro_43 # InterPro IPR009784 DUF1349 # InterPro IPR013320 ConA-like_dom # InterPro IPR023296 Glyco_hydro_beta-prop # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00500 Starch and sucrose metabolism # KEGG_Pathway ko00520 Amino sugar and nucleotide sugar metabolism # Organism YAGH_ECOLI Escherichia coli (strain K12) # PANTHER PTHR22925 PTHR22925 # PATRIC 32115663 VBIEscCol129921_0275 # PIR G64752 G64752 # Pfam PF04616 Glyco_hydro_43 # Pfam PF07081 DUF1349 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAGH_ECOLI Putative beta-xylosidase # RefSeq NP_414805 NC_000913.3 # RefSeq WP_000406871 NZ_LN832404.1 # SIMILARITY Belongs to the glycosyl hydrolase 43 family. {ECO 0000305}. # SUPFAM SSF49899 SSF49899 # SUPFAM SSF75005 SSF75005 # eggNOG COG3507 LUCA # eggNOG ENOG4105DSG Bacteria BLAST swissprot:YAGH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAGH_ECOLI BioCyc ECOL316407:JW0264-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0264-MONOMER BioCyc EcoCyc:G6143-MONOMER http://biocyc.org/getid?id=EcoCyc:G6143-MONOMER COG COG3507 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3507 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.2.1.37 http://www.genome.jp/dbget-bin/www_bget?EC:3.2.1.37 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 ENZYME 3.2.1.37 http://enzyme.expasy.org/EC/3.2.1.37 EchoBASE EB3131 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3131 EcoGene EG13347 http://www.ecogene.org/geneInfo.php?eg_id=EG13347 EnsemblBacteria AAC73374 http://www.ensemblgenomes.org/id/AAC73374 EnsemblBacteria AAC73374 http://www.ensemblgenomes.org/id/AAC73374 EnsemblBacteria BAE76055 http://www.ensemblgenomes.org/id/BAE76055 EnsemblBacteria BAE76055 http://www.ensemblgenomes.org/id/BAE76055 EnsemblBacteria BAE76055 http://www.ensemblgenomes.org/id/BAE76055 EnsemblBacteria b0271 http://www.ensemblgenomes.org/id/b0271 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0009044 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009044 GO_process GO:0045493 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045493 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 2.115.10.20 http://www.cathdb.info/version/latest/superfamily/2.115.10.20 Gene3D 2.60.120.200 http://www.cathdb.info/version/latest/superfamily/2.60.120.200 GeneID 944949 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944949 HOGENOM HOG000112982 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000112982&db=HOGENOM6 InParanoid P77713 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77713 IntAct P77713 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77713* IntEnz 3.2.1.37 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.2.1.37 InterPro IPR006710 http://www.ebi.ac.uk/interpro/entry/IPR006710 InterPro IPR009784 http://www.ebi.ac.uk/interpro/entry/IPR009784 InterPro IPR013320 http://www.ebi.ac.uk/interpro/entry/IPR013320 InterPro IPR023296 http://www.ebi.ac.uk/interpro/entry/IPR023296 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0264 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0264 KEGG_Gene eco:b0271 http://www.genome.jp/dbget-bin/www_bget?eco:b0271 KEGG_Orthology KO:K01198 http://www.genome.jp/dbget-bin/www_bget?KO:K01198 KEGG_Pathway ko00500 http://www.genome.jp/kegg-bin/show_pathway?ko00500 KEGG_Pathway ko00520 http://www.genome.jp/kegg-bin/show_pathway?ko00520 KEGG_Reaction rn:R01433 http://www.genome.jp/dbget-bin/www_bget?rn:R01433 OMA VCSSFEY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VCSSFEY PANTHER PTHR22925 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22925 PSORT swissprot:YAGH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAGH_ECOLI PSORT-B swissprot:YAGH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAGH_ECOLI PSORT2 swissprot:YAGH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAGH_ECOLI Pfam PF04616 http://pfam.xfam.org/family/PF04616 Pfam PF07081 http://pfam.xfam.org/family/PF07081 Phobius swissprot:YAGH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAGH_ECOLI PhylomeDB P77713 http://phylomedb.org/?seqid=P77713 ProteinModelPortal P77713 http://www.proteinmodelportal.org/query/uniprot/P77713 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414805 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414805 RefSeq WP_000406871 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000406871 SMR P77713 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77713 STRING 511145.b0271 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0271&targetmode=cogs STRING COG3507 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3507&targetmode=cogs SUPFAM SSF49899 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49899 SUPFAM SSF75005 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF75005 UniProtKB YAGH_ECOLI http://www.uniprot.org/uniprot/YAGH_ECOLI UniProtKB-AC P77713 http://www.uniprot.org/uniprot/P77713 charge swissprot:YAGH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAGH_ECOLI eggNOG COG3507 http://eggnogapi.embl.de/nog_data/html/tree/COG3507 eggNOG ENOG4105DSG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DSG epestfind swissprot:YAGH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAGH_ECOLI garnier swissprot:YAGH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAGH_ECOLI helixturnhelix swissprot:YAGH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAGH_ECOLI hmoment swissprot:YAGH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAGH_ECOLI iep swissprot:YAGH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAGH_ECOLI inforesidue swissprot:YAGH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAGH_ECOLI octanol swissprot:YAGH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAGH_ECOLI pepcoil swissprot:YAGH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAGH_ECOLI pepdigest swissprot:YAGH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAGH_ECOLI pepinfo swissprot:YAGH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAGH_ECOLI pepnet swissprot:YAGH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAGH_ECOLI pepstats swissprot:YAGH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAGH_ECOLI pepwheel swissprot:YAGH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAGH_ECOLI pepwindow swissprot:YAGH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAGH_ECOLI sigcleave swissprot:YAGH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAGH_ECOLI ## Database ID URL or Descriptions # BRENDA 2.7.13 2026 # BioGrid 4262091 11 # CATALYTIC ACTIVITY PHOR_ECOLI ATP + protein L-histidine = ADP + protein N- phospho-L-histidine. # EcoGene EG10733 phoR # FUNCTION PHOR_ECOLI Member of the two-component regulatory system PhoR/PhoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoB in response to environmental signals. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IDA:EcoCyc. # GO_function GO:0000155 phosphorelay sensor kinase activity; IDA:EcoCyc. # GO_function GO:0004721 phosphoprotein phosphatase activity; IMP:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0000160 phosphorelay signal transduction system; IDA:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:InterPro. # GO_process GO:0006817 phosphate ion transport; IEA:UniProtKB-KW. # GO_process GO:0016036 cellular response to phosphate starvation; IEP:EcoCyc. # GO_process GO:0046777 protein autophosphorylation; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005622 intracellular # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0006810 transport # GOslim_process GO:0006950 response to stress # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # Gene3D 1.10.287.130 -; 1. # Gene3D 3.30.565.10 -; 1. # IntAct P08400 4 # InterPro IPR000014 PAS # InterPro IPR003594 HATPase_C # InterPro IPR003661 HisK_dim/P # InterPro IPR004358 Sig_transdc_His_kin-like_C # InterPro IPR005467 His_kinase_dom # InterPro IPR013767 PAS_fold # InterPro IPR014310 Sig_transdc_His_kinase_PhoR # InterPro IPR021766 DUF3329 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01001 Protein kinases # KEGG_Brite ko02022 M00434 PhoR-PhoB (phosphate starvation response) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # Organism PHOR_ECOLI Escherichia coli (strain K12) # PATRIC 32115945 VBIEscCol129921_0414 # PIR A25557 RGECFR # PRINTS PR00344 BCTRLSENSOR # PROSITE PS50109 HIS_KIN # PROSITE PS50112 PAS # Pfam PF00512 HisKA # Pfam PF00989 PAS # Pfam PF02518 HATPase_c # Pfam PF11808 DUF3329 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PHOR_ECOLI Phosphate regulon sensor protein PhoR # RefSeq NP_414934 NC_000913.3 # RefSeq WP_000893623 NZ_LN832404.1 # SIMILARITY Contains 1 PAS (PER-ARNT-SIM) domain. {ECO:0000255|PROSITE-ProRule PRU00140}. # SIMILARITY Contains 1 histidine kinase domain. {ECO:0000255|PROSITE-ProRule PRU00107}. # SMART SM00091 PAS # SMART SM00387 HATPase_c # SMART SM00388 HisKA # SUBCELLULAR LOCATION PHOR_ECOLI Cell inner membrane {ECO 0000269|PubMed 2187152}; Multi-pass membrane protein {ECO 0000269|PubMed 2187152}. # SUPFAM SSF47384 SSF47384 # SUPFAM SSF55785 SSF55785 # SUPFAM SSF55874 SSF55874 # TIGRFAMs TIGR02966 phoR_proteo # eggNOG ENOG4105BZU Bacteria # eggNOG ENOG410XNMH LUCA BLAST swissprot:PHOR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PHOR_ECOLI BioCyc ECOL316407:JW0390-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0390-MONOMER BioCyc EcoCyc:PHOR-MONOMER http://biocyc.org/getid?id=EcoCyc:PHOR-MONOMER COG COG0642 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0642 DIP DIP-10502N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10502N DOI 10.1007/BF00391740 http://dx.doi.org/10.1007/BF00391740 DOI 10.1016/0022-2836(86)90275-5 http://dx.doi.org/10.1016/0022-2836(86)90275-5 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1993.tb01571.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb01571.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.13.3 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.13.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EMBL X04704 http://www.ebi.ac.uk/ena/data/view/X04704 ENZYME 2.7.13.3 http://enzyme.expasy.org/EC/2.7.13.3 EchoBASE EB0726 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0726 EcoGene EG10733 http://www.ecogene.org/geneInfo.php?eg_id=EG10733 EnsemblBacteria AAC73503 http://www.ensemblgenomes.org/id/AAC73503 EnsemblBacteria AAC73503 http://www.ensemblgenomes.org/id/AAC73503 EnsemblBacteria BAE76180 http://www.ensemblgenomes.org/id/BAE76180 EnsemblBacteria BAE76180 http://www.ensemblgenomes.org/id/BAE76180 EnsemblBacteria BAE76180 http://www.ensemblgenomes.org/id/BAE76180 EnsemblBacteria b0400 http://www.ensemblgenomes.org/id/b0400 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0000155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000155 GO_function GO:0004721 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004721 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0006817 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006817 GO_process GO:0016036 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016036 GO_process GO:0046777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046777 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.10.287.130 http://www.cathdb.info/version/latest/superfamily/1.10.287.130 Gene3D 3.30.565.10 http://www.cathdb.info/version/latest/superfamily/3.30.565.10 GeneID 945044 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945044 HOGENOM HOG000223176 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000223176&db=HOGENOM6 InParanoid P08400 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P08400 IntAct P08400 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P08400* IntEnz 2.7.13.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.13.3 InterPro IPR000014 http://www.ebi.ac.uk/interpro/entry/IPR000014 InterPro IPR003594 http://www.ebi.ac.uk/interpro/entry/IPR003594 InterPro IPR003661 http://www.ebi.ac.uk/interpro/entry/IPR003661 InterPro IPR004358 http://www.ebi.ac.uk/interpro/entry/IPR004358 InterPro IPR005467 http://www.ebi.ac.uk/interpro/entry/IPR005467 InterPro IPR013767 http://www.ebi.ac.uk/interpro/entry/IPR013767 InterPro IPR014310 http://www.ebi.ac.uk/interpro/entry/IPR014310 InterPro IPR021766 http://www.ebi.ac.uk/interpro/entry/IPR021766 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01001 http://www.genome.jp/dbget-bin/www_bget?ko01001 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW0390 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0390 KEGG_Gene eco:b0400 http://www.genome.jp/dbget-bin/www_bget?eco:b0400 KEGG_Orthology KO:K07636 http://www.genome.jp/dbget-bin/www_bget?KO:K07636 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 MINT MINT-1288861 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1288861 OMA DINWNIN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DINWNIN PRINTS PR00344 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00344 PROSITE PS50109 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50109 PROSITE PS50112 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50112 PSORT swissprot:PHOR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PHOR_ECOLI PSORT-B swissprot:PHOR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PHOR_ECOLI PSORT2 swissprot:PHOR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PHOR_ECOLI Pfam PF00512 http://pfam.xfam.org/family/PF00512 Pfam PF00989 http://pfam.xfam.org/family/PF00989 Pfam PF02518 http://pfam.xfam.org/family/PF02518 Pfam PF11808 http://pfam.xfam.org/family/PF11808 Phobius swissprot:PHOR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PHOR_ECOLI PhylomeDB P08400 http://phylomedb.org/?seqid=P08400 ProteinModelPortal P08400 http://www.proteinmodelportal.org/query/uniprot/P08400 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2187152 http://www.ncbi.nlm.nih.gov/pubmed/2187152 PubMed 3550103 http://www.ncbi.nlm.nih.gov/pubmed/3550103 PubMed 8391104 http://www.ncbi.nlm.nih.gov/pubmed/8391104 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414934 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414934 RefSeq WP_000893623 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000893623 SMART SM00091 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00091 SMART SM00387 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00387 SMART SM00388 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00388 SMR P08400 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P08400 STRING 511145.b0400 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0400&targetmode=cogs STRING COG0642 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0642&targetmode=cogs SUPFAM SSF47384 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47384 SUPFAM SSF55785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55785 SUPFAM SSF55874 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55874 TIGRFAMs TIGR02966 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02966 UniProtKB PHOR_ECOLI http://www.uniprot.org/uniprot/PHOR_ECOLI UniProtKB-AC P08400 http://www.uniprot.org/uniprot/P08400 charge swissprot:PHOR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PHOR_ECOLI eggNOG ENOG4105BZU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZU eggNOG ENOG410XNMH http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNMH epestfind swissprot:PHOR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PHOR_ECOLI garnier swissprot:PHOR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PHOR_ECOLI helixturnhelix swissprot:PHOR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PHOR_ECOLI hmoment swissprot:PHOR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PHOR_ECOLI iep swissprot:PHOR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PHOR_ECOLI inforesidue swissprot:PHOR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PHOR_ECOLI octanol swissprot:PHOR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PHOR_ECOLI pepcoil swissprot:PHOR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PHOR_ECOLI pepdigest swissprot:PHOR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PHOR_ECOLI pepinfo swissprot:PHOR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PHOR_ECOLI pepnet swissprot:PHOR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PHOR_ECOLI pepstats swissprot:PHOR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PHOR_ECOLI pepwheel swissprot:PHOR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PHOR_ECOLI pepwindow swissprot:PHOR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PHOR_ECOLI sigcleave swissprot:PHOR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PHOR_ECOLI ## Database ID URL or Descriptions # BioGrid 4260634 13 # EcoGene EG13209 yfjW # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # IntAct P52138 2 # Organism YFJW_ECOLI Escherichia coli (strain K12) # PATRIC 32120675 VBIEscCol129921_2736 # PIR D65043 D65043 # PIR T08653 T08653 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFJW_ECOLI Uncharacterized protein YfjW # RefSeq NP_417129 NC_000913.3 # RefSeq WP_000896263 NZ_CP014272.1 # SUBCELLULAR LOCATION YFJW_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # eggNOG ENOG410YF06 LUCA BLAST swissprot:YFJW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFJW_ECOLI BioCyc ECOL316407:JW2623-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2623-MONOMER BioCyc EcoCyc:G7377-MONOMER http://biocyc.org/getid?id=EcoCyc:G7377-MONOMER DIP DIP-12088N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12088N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36840 http://www.ebi.ac.uk/ena/data/view/U36840 EchoBASE EB3001 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3001 EcoGene EG13209 http://www.ecogene.org/geneInfo.php?eg_id=EG13209 EnsemblBacteria AAC75690 http://www.ensemblgenomes.org/id/AAC75690 EnsemblBacteria AAC75690 http://www.ensemblgenomes.org/id/AAC75690 EnsemblBacteria BAA16510 http://www.ensemblgenomes.org/id/BAA16510 EnsemblBacteria BAA16510 http://www.ensemblgenomes.org/id/BAA16510 EnsemblBacteria BAA16510 http://www.ensemblgenomes.org/id/BAA16510 EnsemblBacteria b2642 http://www.ensemblgenomes.org/id/b2642 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 947128 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947128 IntAct P52138 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P52138* KEGG_Gene ecj:JW2623 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2623 KEGG_Gene eco:b2642 http://www.genome.jp/dbget-bin/www_bget?eco:b2642 MINT MINT-1308072 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1308072 PSORT swissprot:YFJW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFJW_ECOLI PSORT-B swissprot:YFJW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFJW_ECOLI PSORT2 swissprot:YFJW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFJW_ECOLI Phobius swissprot:YFJW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFJW_ECOLI ProteinModelPortal P52138 http://www.proteinmodelportal.org/query/uniprot/P52138 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417129 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417129 RefSeq WP_000896263 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000896263 STRING 511145.b2642 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2642&targetmode=cogs UniProtKB YFJW_ECOLI http://www.uniprot.org/uniprot/YFJW_ECOLI UniProtKB-AC P52138 http://www.uniprot.org/uniprot/P52138 charge swissprot:YFJW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFJW_ECOLI eggNOG ENOG410YF06 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YF06 epestfind swissprot:YFJW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFJW_ECOLI garnier swissprot:YFJW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFJW_ECOLI helixturnhelix swissprot:YFJW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFJW_ECOLI hmoment swissprot:YFJW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFJW_ECOLI iep swissprot:YFJW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFJW_ECOLI inforesidue swissprot:YFJW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFJW_ECOLI octanol swissprot:YFJW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFJW_ECOLI pepcoil swissprot:YFJW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFJW_ECOLI pepdigest swissprot:YFJW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFJW_ECOLI pepinfo swissprot:YFJW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFJW_ECOLI pepnet swissprot:YFJW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFJW_ECOLI pepstats swissprot:YFJW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFJW_ECOLI pepwheel swissprot:YFJW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFJW_ECOLI pepwindow swissprot:YFJW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFJW_ECOLI sigcleave swissprot:YFJW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFJW_ECOLI ## Database ID URL or Descriptions # BioGrid 4259571 241 # EcoGene EG11196 yidB # Gene3D 1.10.10.690 -; 1. # IntAct P09996 10 # InterPro IPR009282 DUF937 # InterPro IPR027405 YidB-like # Organism YIDB_ECOLI Escherichia coli (strain K12) # PATRIC 32122891 VBIEscCol129921_3821 # PIR C65172 QQECG1 # Pfam PF06078 DUF937 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIDB_ECOLI Uncharacterized protein YidB # RefSeq NP_418153 NC_000913.3 # RefSeq WP_000522208 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA62049.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SUPFAM SSF140804 SSF140804 # eggNOG COG3753 LUCA # eggNOG ENOG4105VP5 Bacteria BLAST swissprot:YIDB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIDB_ECOLI BioCyc ECOL316407:JW3675-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3675-MONOMER BioCyc EcoCyc:EG11196-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11196-MONOMER DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/15.2.771 http://dx.doi.org/10.1093/nar/15.2.771 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X04341 http://www.ebi.ac.uk/ena/data/view/X04341 EchoBASE EB1182 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1182 EcoGene EG11196 http://www.ecogene.org/geneInfo.php?eg_id=EG11196 EnsemblBacteria AAC76721 http://www.ensemblgenomes.org/id/AAC76721 EnsemblBacteria AAC76721 http://www.ensemblgenomes.org/id/AAC76721 EnsemblBacteria BAE77596 http://www.ensemblgenomes.org/id/BAE77596 EnsemblBacteria BAE77596 http://www.ensemblgenomes.org/id/BAE77596 EnsemblBacteria BAE77596 http://www.ensemblgenomes.org/id/BAE77596 EnsemblBacteria b3698 http://www.ensemblgenomes.org/id/b3698 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 1.10.10.690 http://www.cathdb.info/version/latest/superfamily/1.10.10.690 GeneID 948212 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948212 HOGENOM HOG000261121 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261121&db=HOGENOM6 InParanoid P09996 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P09996 IntAct P09996 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P09996* InterPro IPR009282 http://www.ebi.ac.uk/interpro/entry/IPR009282 InterPro IPR027405 http://www.ebi.ac.uk/interpro/entry/IPR027405 KEGG_Gene ecj:JW3675 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3675 KEGG_Gene eco:b3698 http://www.genome.jp/dbget-bin/www_bget?eco:b3698 OMA ILPHVVN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ILPHVVN PSORT swissprot:YIDB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIDB_ECOLI PSORT-B swissprot:YIDB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIDB_ECOLI PSORT2 swissprot:YIDB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIDB_ECOLI Pfam PF06078 http://pfam.xfam.org/family/PF06078 Phobius swissprot:YIDB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIDB_ECOLI PhylomeDB P09996 http://phylomedb.org/?seqid=P09996 ProteinModelPortal P09996 http://www.proteinmodelportal.org/query/uniprot/P09996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3029692 http://www.ncbi.nlm.nih.gov/pubmed/3029692 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418153 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418153 RefSeq WP_000522208 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000522208 SMR P09996 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P09996 STRING 511145.b3698 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3698&targetmode=cogs SUPFAM SSF140804 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF140804 UniProtKB YIDB_ECOLI http://www.uniprot.org/uniprot/YIDB_ECOLI UniProtKB-AC P09996 http://www.uniprot.org/uniprot/P09996 charge swissprot:YIDB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIDB_ECOLI eggNOG COG3753 http://eggnogapi.embl.de/nog_data/html/tree/COG3753 eggNOG ENOG4105VP5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VP5 epestfind swissprot:YIDB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIDB_ECOLI garnier swissprot:YIDB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIDB_ECOLI helixturnhelix swissprot:YIDB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIDB_ECOLI hmoment swissprot:YIDB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIDB_ECOLI iep swissprot:YIDB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIDB_ECOLI inforesidue swissprot:YIDB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIDB_ECOLI octanol swissprot:YIDB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIDB_ECOLI pepcoil swissprot:YIDB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIDB_ECOLI pepdigest swissprot:YIDB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIDB_ECOLI pepinfo swissprot:YIDB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIDB_ECOLI pepnet swissprot:YIDB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIDB_ECOLI pepstats swissprot:YIDB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIDB_ECOLI pepwheel swissprot:YIDB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIDB_ECOLI pepwindow swissprot:YIDB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIDB_ECOLI sigcleave swissprot:YIDB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIDB_ECOLI ## Database ID URL or Descriptions # BioGrid 4259698 160 # DISRUPTION PHENOTYPE Null mutation abolishes ECA(CYC) synthesis. {ECO:0000269|PubMed 16199561}. # EcoGene EG11295 wzzE # FUNCTION WZZE_ECOLI Modulates the polysaccharide chain length of enterobacterial common antigen (ECA). Required for the assembly of the phosphoglyceride-linked form of ECA (ECA(PG)) and the water- soluble cyclic form of ECA (ECA(CYC)). {ECO 0000269|PubMed 10515954, ECO 0000269|PubMed 16199561}. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0004713 protein tyrosine kinase activity; IBA:GO_Central. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IEA:InterPro. # GO_process GO:0009246 enterobacterial common antigen biosynthetic process; IMP:EcoCyc. # GO_process GO:0038083 peptidyl-tyrosine autophosphorylation; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016301 kinase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # HAMAP MF_02025 WzzE # InterPro IPR003856 LipoPS_biosynth # InterPro IPR032895 WzzE # Organism WZZE_ECOLI Escherichia coli (strain K12) # PATHWAY WZZE_ECOLI Bacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis. {ECO 0000255|HAMAP-Rule MF_02025, ECO 0000269|PubMed 10515954, ECO 0000269|PubMed 16199561}. # PATRIC 32123063 VBIEscCol129921_3901 # PIR D65182 D65182 # Pfam PF02706 Wzz # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ECA polysaccharide chain length modulation protein {ECO:0000255|HAMAP-Rule MF_02025, ECO:0000305} # RefSeq NP_418232 NC_000913.3 # RefSeq WP_001295256 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA67585.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the WzzB/Cld/Rol family. {ECO:0000255|HAMAP-Rule MF_02025}. # SUBCELLULAR LOCATION WZZE_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_02025, ECO 0000305}; Multi-pass membrane protein {ECO 0000255|HAMAP-Rule MF_02025}. # SUBUNIT WZZE_ECOLI Probably part of a complex composed of WzxE, WzyE and WzzE. {ECO 0000255|HAMAP-Rule MF_02025, ECO 0000305|PubMed 16816184}. # eggNOG COG3765 LUCA # eggNOG ENOG4105SFE Bacteria BLAST swissprot:WZZE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:WZZE_ECOLI BioCyc ECOL316407:JW5601-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5601-MONOMER BioCyc EcoCyc:EG11295-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11295-MONOMER BioCyc MetaCyc:EG11295-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11295-MONOMER COG COG3765 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3765 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00461-06 http://dx.doi.org/10.1128/JB.00461-06 DOI 10.1128/JB.187.20.6917-6927.2005 http://dx.doi.org/10.1128/JB.187.20.6917-6927.2005 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M76129 http://www.ebi.ac.uk/ena/data/view/M76129 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1272 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1272 EcoGene EG11295 http://www.ecogene.org/geneInfo.php?eg_id=EG11295 EnsemblBacteria AAC76790 http://www.ensemblgenomes.org/id/AAC76790 EnsemblBacteria AAC76790 http://www.ensemblgenomes.org/id/AAC76790 EnsemblBacteria BAE77513 http://www.ensemblgenomes.org/id/BAE77513 EnsemblBacteria BAE77513 http://www.ensemblgenomes.org/id/BAE77513 EnsemblBacteria BAE77513 http://www.ensemblgenomes.org/id/BAE77513 EnsemblBacteria b3785 http://www.ensemblgenomes.org/id/b3785 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0004713 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004713 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GO_process GO:0009246 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009246 GO_process GO:0038083 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0038083 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 944815 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944815 HAMAP MF_02025 http://hamap.expasy.org/unirule/MF_02025 HOGENOM HOG000126437 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126437&db=HOGENOM6 InParanoid P0AG00 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AG00 InterPro IPR003856 http://www.ebi.ac.uk/interpro/entry/IPR003856 InterPro IPR032895 http://www.ebi.ac.uk/interpro/entry/IPR032895 KEGG_Gene ecj:JW5601 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5601 KEGG_Gene eco:b3785 http://www.genome.jp/dbget-bin/www_bget?eco:b3785 KEGG_Orthology KO:K05790 http://www.genome.jp/dbget-bin/www_bget?KO:K05790 OMA AYDTRRE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AYDTRRE PSORT swissprot:WZZE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:WZZE_ECOLI PSORT-B swissprot:WZZE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:WZZE_ECOLI PSORT2 swissprot:WZZE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:WZZE_ECOLI Pfam PF02706 http://pfam.xfam.org/family/PF02706 Phobius swissprot:WZZE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:WZZE_ECOLI PhylomeDB P0AG00 http://phylomedb.org/?seqid=P0AG00 ProteinModelPortal P0AG00 http://www.proteinmodelportal.org/query/uniprot/P0AG00 PubMed 10515954 http://www.ncbi.nlm.nih.gov/pubmed/10515954 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16199561 http://www.ncbi.nlm.nih.gov/pubmed/16199561 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16816184 http://www.ncbi.nlm.nih.gov/pubmed/16816184 PubMed 1730666 http://www.ncbi.nlm.nih.gov/pubmed/1730666 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418232 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418232 RefSeq WP_001295256 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295256 SMR P0AG00 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AG00 STRING 511145.b3785 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3785&targetmode=cogs STRING COG3765 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3765&targetmode=cogs UniProtKB WZZE_ECOLI http://www.uniprot.org/uniprot/WZZE_ECOLI UniProtKB-AC P0AG00 http://www.uniprot.org/uniprot/P0AG00 charge swissprot:WZZE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:WZZE_ECOLI eggNOG COG3765 http://eggnogapi.embl.de/nog_data/html/tree/COG3765 eggNOG ENOG4105SFE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105SFE epestfind swissprot:WZZE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:WZZE_ECOLI garnier swissprot:WZZE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:WZZE_ECOLI helixturnhelix swissprot:WZZE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:WZZE_ECOLI hmoment swissprot:WZZE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:WZZE_ECOLI iep swissprot:WZZE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:WZZE_ECOLI inforesidue swissprot:WZZE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:WZZE_ECOLI octanol swissprot:WZZE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:WZZE_ECOLI pepcoil swissprot:WZZE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:WZZE_ECOLI pepdigest swissprot:WZZE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:WZZE_ECOLI pepinfo swissprot:WZZE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:WZZE_ECOLI pepnet swissprot:WZZE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:WZZE_ECOLI pepstats swissprot:WZZE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:WZZE_ECOLI pepwheel swissprot:WZZE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:WZZE_ECOLI pepwindow swissprot:WZZE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:WZZE_ECOLI sigcleave swissprot:WZZE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:WZZE_ECOLI ## Database ID URL or Descriptions # EcoGene EG40008 insH7 # FUNCTION INSH7_ECOLI Involved in the transposition of the insertion sequence IS5. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # InterPro IPR002559 Transposase_11 # InterPro IPR008490 Transposase_InsH_N # Organism INSH7_ECOLI Escherichia coli (strain K12) # Pfam PF01609 DDE_Tnp_1 # Pfam PF05598 DUF772 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSH7_ECOLI Transposase InsH for insertion sequence element IS5I # RefSeq NP_414793 NC_000913.3 # RefSeq NP_415084 NC_000913.3 # RefSeq NP_415189 NC_000913.3 # RefSeq NP_415847 NC_000913.3 # RefSeq NP_416535 NC_000913.3 # RefSeq NP_416696 NC_000913.3 # RefSeq NP_417456 NC_000913.3 # RefSeq NP_417685 NC_000913.3 # RefSeq NP_417962 NC_000913.3 # SIMILARITY Belongs to the transposase 11 family. {ECO 0000305}. # eggNOG COG3039 LUCA # eggNOG ENOG4105F2I Bacteria BLAST swissprot:INSH7_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSH7_ECOLI BioCyc EcoCyc:MONOMER0-4237 http://biocyc.org/getid?id=EcoCyc:MONOMER0-4237 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4733 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4733 EcoGene EG40008 http://www.ecogene.org/geneInfo.php?eg_id=EG40008 EnsemblBacteria AAC75091 http://www.ensemblgenomes.org/id/AAC75091 EnsemblBacteria AAC75091 http://www.ensemblgenomes.org/id/AAC75091 EnsemblBacteria BAA15871 http://www.ensemblgenomes.org/id/BAA15871 EnsemblBacteria BAA15871 http://www.ensemblgenomes.org/id/BAA15871 EnsemblBacteria BAA15871 http://www.ensemblgenomes.org/id/BAA15871 EnsemblBacteria b2030 http://www.ensemblgenomes.org/id/b2030 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GeneID 944917 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944917 GeneID 944941 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944941 GeneID 945896 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945896 GeneID 946163 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946163 GeneID 946577 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946577 GeneID 947516 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947516 GeneID 947743 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947743 GeneID 948015 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948015 GeneID 949121 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949121 InParanoid P0CE54 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CE54 InterPro IPR002559 http://www.ebi.ac.uk/interpro/entry/IPR002559 InterPro IPR008490 http://www.ebi.ac.uk/interpro/entry/IPR008490 KEGG_Gene ecj:JW2014 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2014 KEGG_Gene eco:b0259 http://www.genome.jp/dbget-bin/www_bget?eco:b0259 KEGG_Gene eco:b0552 http://www.genome.jp/dbget-bin/www_bget?eco:b0552 KEGG_Gene eco:b0656 http://www.genome.jp/dbget-bin/www_bget?eco:b0656 KEGG_Gene eco:b1331 http://www.genome.jp/dbget-bin/www_bget?eco:b1331 KEGG_Gene eco:b2030 http://www.genome.jp/dbget-bin/www_bget?eco:b2030 KEGG_Gene eco:b2192 http://www.genome.jp/dbget-bin/www_bget?eco:b2192 KEGG_Gene eco:b2982 http://www.genome.jp/dbget-bin/www_bget?eco:b2982 KEGG_Gene eco:b3218 http://www.genome.jp/dbget-bin/www_bget?eco:b3218 KEGG_Gene eco:b3505 http://www.genome.jp/dbget-bin/www_bget?eco:b3505 PSORT swissprot:INSH7_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSH7_ECOLI PSORT-B swissprot:INSH7_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSH7_ECOLI PSORT2 swissprot:INSH7_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSH7_ECOLI Pfam PF01609 http://pfam.xfam.org/family/PF01609 Pfam PF05598 http://pfam.xfam.org/family/PF05598 Phobius swissprot:INSH7_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSH7_ECOLI PhylomeDB P0CE54 http://phylomedb.org/?seqid=P0CE54 ProteinModelPortal P0CE54 http://www.proteinmodelportal.org/query/uniprot/P0CE54 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414793 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414793 RefSeq NP_415084 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415084 RefSeq NP_415189 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415189 RefSeq NP_415847 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415847 RefSeq NP_416535 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416535 RefSeq NP_416696 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416696 RefSeq NP_417456 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417456 RefSeq NP_417685 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417685 RefSeq NP_417962 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417962 SMR P0CE54 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0CE54 STRING 511145.b3505 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3505&targetmode=cogs UniProtKB INSH7_ECOLI http://www.uniprot.org/uniprot/INSH7_ECOLI UniProtKB-AC P0CE54 http://www.uniprot.org/uniprot/P0CE54 charge swissprot:INSH7_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSH7_ECOLI eggNOG COG3039 http://eggnogapi.embl.de/nog_data/html/tree/COG3039 eggNOG ENOG4105F2I http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F2I epestfind swissprot:INSH7_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSH7_ECOLI garnier swissprot:INSH7_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSH7_ECOLI helixturnhelix swissprot:INSH7_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSH7_ECOLI hmoment swissprot:INSH7_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSH7_ECOLI iep swissprot:INSH7_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSH7_ECOLI inforesidue swissprot:INSH7_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSH7_ECOLI octanol swissprot:INSH7_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSH7_ECOLI pepcoil swissprot:INSH7_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSH7_ECOLI pepdigest swissprot:INSH7_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSH7_ECOLI pepinfo swissprot:INSH7_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSH7_ECOLI pepnet swissprot:INSH7_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSH7_ECOLI pepstats swissprot:INSH7_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSH7_ECOLI pepwheel swissprot:INSH7_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSH7_ECOLI pepwindow swissprot:INSH7_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSH7_ECOLI sigcleave swissprot:INSH7_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSH7_ECOLI ## Database ID URL or Descriptions # BioGrid 4261053 11 # EcoGene EG14307 yodC # IntAct P64517 4 # InterPro IPR019226 DUF2158 # Organism YODC_ECOLI Escherichia coli (strain K12) # PATRIC 32119243 VBIEscCol129921_2036 # PIR A64960 A64960 # Pfam PF09926 DUF2158 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YODC_ECOLI Uncharacterized protein YodC # RefSeq NP_416466 NC_000913.3 # RefSeq WP_000009307 NZ_LN832404.1 # eggNOG COG5475 LUCA # eggNOG ENOG4105VNZ Bacteria BLAST swissprot:YODC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YODC_ECOLI BioCyc ECOL316407:JW1940-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1940-MONOMER BioCyc EcoCyc:G7050-MONOMER http://biocyc.org/getid?id=EcoCyc:G7050-MONOMER DIP DIP-48226N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48226N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4054 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4054 EcoGene EG14307 http://www.ecogene.org/geneInfo.php?eg_id=EG14307 EnsemblBacteria AAC75023 http://www.ensemblgenomes.org/id/AAC75023 EnsemblBacteria AAC75023 http://www.ensemblgenomes.org/id/AAC75023 EnsemblBacteria BAE76556 http://www.ensemblgenomes.org/id/BAE76556 EnsemblBacteria BAE76556 http://www.ensemblgenomes.org/id/BAE76556 EnsemblBacteria BAE76556 http://www.ensemblgenomes.org/id/BAE76556 EnsemblBacteria b1957 http://www.ensemblgenomes.org/id/b1957 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946466 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946466 HOGENOM HOG000267964 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267964&db=HOGENOM6 IntAct P64517 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P64517* InterPro IPR019226 http://www.ebi.ac.uk/interpro/entry/IPR019226 KEGG_Gene ecj:JW1940 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1940 KEGG_Gene eco:b1957 http://www.genome.jp/dbget-bin/www_bget?eco:b1957 OMA KNGGPRM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KNGGPRM PSORT swissprot:YODC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YODC_ECOLI PSORT-B swissprot:YODC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YODC_ECOLI PSORT2 swissprot:YODC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YODC_ECOLI Pfam PF09926 http://pfam.xfam.org/family/PF09926 Phobius swissprot:YODC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YODC_ECOLI ProteinModelPortal P64517 http://www.proteinmodelportal.org/query/uniprot/P64517 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416466 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416466 RefSeq WP_000009307 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000009307 STRING 511145.b1957 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1957&targetmode=cogs UniProtKB YODC_ECOLI http://www.uniprot.org/uniprot/YODC_ECOLI UniProtKB-AC P64517 http://www.uniprot.org/uniprot/P64517 charge swissprot:YODC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YODC_ECOLI eggNOG COG5475 http://eggnogapi.embl.de/nog_data/html/tree/COG5475 eggNOG ENOG4105VNZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VNZ epestfind swissprot:YODC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YODC_ECOLI garnier swissprot:YODC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YODC_ECOLI helixturnhelix swissprot:YODC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YODC_ECOLI hmoment swissprot:YODC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YODC_ECOLI iep swissprot:YODC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YODC_ECOLI inforesidue swissprot:YODC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YODC_ECOLI octanol swissprot:YODC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YODC_ECOLI pepcoil swissprot:YODC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YODC_ECOLI pepdigest swissprot:YODC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YODC_ECOLI pepinfo swissprot:YODC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YODC_ECOLI pepnet swissprot:YODC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YODC_ECOLI pepstats swissprot:YODC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YODC_ECOLI pepwheel swissprot:YODC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YODC_ECOLI pepwindow swissprot:YODC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YODC_ECOLI sigcleave swissprot:YODC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YODC_ECOLI ## Database ID URL or Descriptions # BioGrid 4261426 9 # EcoGene EG10485 hypC # FUNCTION HYPC_ECOLI Is required for the formation of all three hydrogenase isoenzymes. May bind to the precursor form of the large subunit of dehydrogenases to keep them in a conformation accessible for metal incorporation. # GO_function GO:0005506 iron ion binding; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:1902670 carbon dioxide binding; IDA:EcoCyc. # GO_process GO:0051604 protein maturation; IDA:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0051604 protein maturation # IntAct P0AAM3 9 # InterPro IPR001109 Hydrogenase_HupF/HypC # InterPro IPR019812 Hydgase_assmbl_chp_CS # Organism HYPC_ECOLI Escherichia coli (strain K12) # PATRIC 32120856 VBIEscCol129921_2820 # PDB 2OT2 NMR; -; A=1-90 # PIR S15199 S15199 # PRINTS PR00445 HUPFHYPC # PROSITE PS01097 HUPF_HYPC # Pfam PF01455 HupF_HypC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HYPC_ECOLI Hydrogenase isoenzymes formation protein HypC # RefSeq NP_417208 NC_000913.3 # RefSeq WP_000334881 NZ_LN832404.1 # SIMILARITY Belongs to the HupF/HypC family. {ECO 0000305}. # TIGRFAMs TIGR00074 hypC_hupF # eggNOG COG0298 LUCA # eggNOG ENOG41083WG Bacteria BLAST swissprot:HYPC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HYPC_ECOLI BioCyc ECOL316407:JW2698-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2698-MONOMER BioCyc EcoCyc:EG10485-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10485-MONOMER COG COG0298 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0298 DIP DIP-36430N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36430N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1021/bi9720078 http://dx.doi.org/10.1021/bi9720078 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1991.tb01833.x http://dx.doi.org/10.1111/j.1365-2958.1991.tb01833.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EMBL X54543 http://www.ebi.ac.uk/ena/data/view/X54543 EchoBASE EB0480 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0480 EcoGene EG10485 http://www.ecogene.org/geneInfo.php?eg_id=EG10485 EnsemblBacteria AAC75770 http://www.ensemblgenomes.org/id/AAC75770 EnsemblBacteria AAC75770 http://www.ensemblgenomes.org/id/AAC75770 EnsemblBacteria BAE76805 http://www.ensemblgenomes.org/id/BAE76805 EnsemblBacteria BAE76805 http://www.ensemblgenomes.org/id/BAE76805 EnsemblBacteria BAE76805 http://www.ensemblgenomes.org/id/BAE76805 EnsemblBacteria b2728 http://www.ensemblgenomes.org/id/b2728 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:1902670 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902670 GO_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 GeneID 947192 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947192 HOGENOM HOG000278755 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278755&db=HOGENOM6 InParanoid P0AAM3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAM3 IntAct P0AAM3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAM3* InterPro IPR001109 http://www.ebi.ac.uk/interpro/entry/IPR001109 InterPro IPR019812 http://www.ebi.ac.uk/interpro/entry/IPR019812 KEGG_Gene ecj:JW2698 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2698 KEGG_Gene eco:b2728 http://www.genome.jp/dbget-bin/www_bget?eco:b2728 KEGG_Orthology KO:K04653 http://www.genome.jp/dbget-bin/www_bget?KO:K04653 MINT MINT-1223094 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1223094 OMA QKMGADY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QKMGADY PDB 2OT2 http://www.ebi.ac.uk/pdbe-srv/view/entry/2OT2 PDBsum 2OT2 http://www.ebi.ac.uk/pdbsum/2OT2 PRINTS PR00445 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00445 PROSITE PS01097 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01097 PSORT swissprot:HYPC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HYPC_ECOLI PSORT-B swissprot:HYPC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HYPC_ECOLI PSORT2 swissprot:HYPC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HYPC_ECOLI Pfam PF01455 http://pfam.xfam.org/family/PF01455 Phobius swissprot:HYPC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HYPC_ECOLI PhylomeDB P0AAM3 http://phylomedb.org/?seqid=P0AAM3 ProteinModelPortal P0AAM3 http://www.proteinmodelportal.org/query/uniprot/P0AAM3 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1849603 http://www.ncbi.nlm.nih.gov/pubmed/1849603 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9485446 http://www.ncbi.nlm.nih.gov/pubmed/9485446 RefSeq NP_417208 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417208 RefSeq WP_000334881 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000334881 SMR P0AAM3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAM3 STRING 511145.b2728 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2728&targetmode=cogs STRING COG0298 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0298&targetmode=cogs TIGRFAMs TIGR00074 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00074 UniProtKB HYPC_ECOLI http://www.uniprot.org/uniprot/HYPC_ECOLI UniProtKB-AC P0AAM3 http://www.uniprot.org/uniprot/P0AAM3 charge swissprot:HYPC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HYPC_ECOLI eggNOG COG0298 http://eggnogapi.embl.de/nog_data/html/tree/COG0298 eggNOG ENOG41083WG http://eggnogapi.embl.de/nog_data/html/tree/ENOG41083WG epestfind swissprot:HYPC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HYPC_ECOLI garnier swissprot:HYPC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HYPC_ECOLI helixturnhelix swissprot:HYPC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HYPC_ECOLI hmoment swissprot:HYPC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HYPC_ECOLI iep swissprot:HYPC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HYPC_ECOLI inforesidue swissprot:HYPC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HYPC_ECOLI octanol swissprot:HYPC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HYPC_ECOLI pepcoil swissprot:HYPC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HYPC_ECOLI pepdigest swissprot:HYPC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HYPC_ECOLI pepinfo swissprot:HYPC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HYPC_ECOLI pepnet swissprot:HYPC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HYPC_ECOLI pepstats swissprot:HYPC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HYPC_ECOLI pepwheel swissprot:HYPC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HYPC_ECOLI pepwindow swissprot:HYPC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HYPC_ECOLI sigcleave swissprot:HYPC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HYPC_ECOLI ## Database ID URL or Descriptions # CATALYTIC ACTIVITY ATP + H(2)O + phosphonate(Out) = ADP + phosphate + phosphonate(In). {ECO:0000255|HAMAP-Rule MF_01713}. # CDD cd03256 ABC_PhnC_transporter # EcoGene EG10713 phnC # FUNCTION PHNC_ECOLI Part of the ABC transporter complex PhnCDE involved in phosphonates, phosphate esters, phosphite and phosphate import. Responsible for energy coupling to the transport system. {ECO 0000269|PubMed 1846145, ECO 0000269|PubMed 8388873}. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IEA:UniProtKB-HAMAP. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0015416 ATPase-coupled organic phosphonate transmembrane transporter activity; IEA:UniProtKB-HAMAP. # GO_process GO:0042916 alkylphosphonate transport; IMP:EcoCyc. # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # Gene3D 3.40.50.300 -; 1. # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR012693 ABC_transpr_PhnC # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00223 Phosphonate transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # MISCELLANEOUS PHNC_ECOLI Phosphonates utilization is cryptic in strain K12. # Organism PHNC_ECOLI Escherichia coli (strain K12) # PATRIC 32123771 VBIEscCol129921_4234 # PIR A65220 A65220 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # PROSITE PS51249 PHNC # Pfam PF00005 ABC_tran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Phosphonates import ATP-binding protein PhnC {ECO:0000255|HAMAP-Rule MF_01713} # RefSeq NP_418530 NC_000913.3 # RefSeq WP_001193409 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family. {ECO:0000255|HAMAP- Rule MF_01713}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|HAMAP- Rule MF_01713}. # SMART SM00382 AAA # SUBCELLULAR LOCATION PHNC_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01713}; Peripheral membrane protein {ECO 0000255|HAMAP- Rule MF_01713}. # SUBUNIT The complex is composed of two ATP-binding proteins (PhnC), two transmembrane proteins (PhnE) and a solute-binding protein (PhnD). {ECO:0000255|HAMAP-Rule MF_01713}. # SUPFAM SSF52540 SSF52540 # TCDB 3.A.1.9 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR02315 ABC_phnC # eggNOG COG3638 LUCA # eggNOG ENOG4105D5T Bacteria BLAST swissprot:PHNC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PHNC_ECOLI BioCyc ECOL316407:JW4067-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4067-MONOMER BioCyc EcoCyc:PHNC-MONOMER http://biocyc.org/getid?id=EcoCyc:PHNC-MONOMER BioCyc MetaCyc:PHNC-MONOMER http://biocyc.org/getid?id=MetaCyc:PHNC-MONOMER COG COG3638 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3638 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.3.28 {ECO:0000255|HAMAP-Rule:MF_01713} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.28 {ECO:0000255|HAMAP-Rule:MF_01713} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D90227 http://www.ebi.ac.uk/ena/data/view/D90227 EMBL J05260 http://www.ebi.ac.uk/ena/data/view/J05260 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 3.6.3.28 {ECO:0000255|HAMAP-Rule:MF_01713} http://enzyme.expasy.org/EC/3.6.3.28 {ECO:0000255|HAMAP-Rule:MF_01713} EchoBASE EB0707 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0707 EcoGene EG10713 http://www.ecogene.org/geneInfo.php?eg_id=EG10713 EnsemblBacteria AAC77067 http://www.ensemblgenomes.org/id/AAC77067 EnsemblBacteria AAC77067 http://www.ensemblgenomes.org/id/AAC77067 EnsemblBacteria BAE78108 http://www.ensemblgenomes.org/id/BAE78108 EnsemblBacteria BAE78108 http://www.ensemblgenomes.org/id/BAE78108 EnsemblBacteria BAE78108 http://www.ensemblgenomes.org/id/BAE78108 EnsemblBacteria b4106 http://www.ensemblgenomes.org/id/b4106 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0015416 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015416 GO_process GO:0042916 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042916 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948623 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948623 InParanoid P16677 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P16677 IntAct P16677 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P16677* IntEnz 3.6.3.28 {ECO:0000255|HAMAP-Rule:MF_01713} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.28 {ECO:0000255|HAMAP-Rule:MF_01713} InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR012693 http://www.ebi.ac.uk/interpro/entry/IPR012693 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW4067 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4067 KEGG_Gene eco:b4106 http://www.genome.jp/dbget-bin/www_bget?eco:b4106 KEGG_Orthology KO:K02041 http://www.genome.jp/dbget-bin/www_bget?KO:K02041 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA GMAHFAH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GMAHFAH PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PROSITE PS51249 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51249 PSORT swissprot:PHNC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PHNC_ECOLI PSORT-B swissprot:PHNC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PHNC_ECOLI PSORT2 swissprot:PHNC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PHNC_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Phobius swissprot:PHNC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PHNC_ECOLI PhylomeDB P16677 http://phylomedb.org/?seqid=P16677 ProteinModelPortal P16677 http://www.proteinmodelportal.org/query/uniprot/P16677 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1840580 http://www.ncbi.nlm.nih.gov/pubmed/1840580 PubMed 1846145 http://www.ncbi.nlm.nih.gov/pubmed/1846145 PubMed 2155230 http://www.ncbi.nlm.nih.gov/pubmed/2155230 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8388873 http://www.ncbi.nlm.nih.gov/pubmed/8388873 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418530 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418530 RefSeq WP_001193409 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001193409 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P16677 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P16677 STRING 511145.b4106 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4106&targetmode=cogs STRING COG3638 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3638&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.9 http://www.tcdb.org/search/result.php?tc=3.A.1.9 TIGRFAMs TIGR02315 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02315 UniProtKB PHNC_ECOLI http://www.uniprot.org/uniprot/PHNC_ECOLI UniProtKB-AC P16677 http://www.uniprot.org/uniprot/P16677 charge swissprot:PHNC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PHNC_ECOLI eggNOG COG3638 http://eggnogapi.embl.de/nog_data/html/tree/COG3638 eggNOG ENOG4105D5T http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D5T epestfind swissprot:PHNC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PHNC_ECOLI garnier swissprot:PHNC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PHNC_ECOLI helixturnhelix swissprot:PHNC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PHNC_ECOLI hmoment swissprot:PHNC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PHNC_ECOLI iep swissprot:PHNC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PHNC_ECOLI inforesidue swissprot:PHNC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PHNC_ECOLI octanol swissprot:PHNC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PHNC_ECOLI pepcoil swissprot:PHNC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PHNC_ECOLI pepdigest swissprot:PHNC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PHNC_ECOLI pepinfo swissprot:PHNC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PHNC_ECOLI pepnet swissprot:PHNC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PHNC_ECOLI pepstats swissprot:PHNC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PHNC_ECOLI pepwheel swissprot:PHNC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PHNC_ECOLI pepwindow swissprot:PHNC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PHNC_ECOLI sigcleave swissprot:PHNC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PHNC_ECOLI ## Database ID URL or Descriptions # BioGrid 4262463 6 # CAUTION Was originally thought to be involved in the regulation of the labile hydrogenase activity. {ECO:0000305|PubMed 2666400}. # EcoGene EG10482 zraR # FUNCTION ZRAR_ECOLI Member of the two-component regulatory system ZraS/ZraR. When activated by ZraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0000156 phosphorelay response regulator activity; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IDA:EcoliWiki. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0043565 sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0000160 phosphorelay signal transduction system; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEP:EcoCyc. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; ISS:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.60 -; 1. # Gene3D 3.40.50.300 -; 1. # InterPro IPR001789 Sig_transdc_resp-reg_receiver # InterPro IPR002078 Sigma_54_int # InterPro IPR002197 HTH_Fis # InterPro IPR003593 AAA+_ATPase # InterPro IPR009057 Homeodomain-like # InterPro IPR011006 CheY-like_superfamily # InterPro IPR025662 Sigma_54_int_dom_ATP-bd_1 # InterPro IPR025943 Sigma_54_int_dom_ATP-bd_2 # InterPro IPR025944 Sigma_54_int_dom_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02022 M00499 HydH-HydG (metal tolerance) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # Organism ZRAR_ECOLI Escherichia coli (strain K12) # PATRIC 32123533 VBIEscCol129921_4119 # PIR G65207 B33862 # PRINTS PR01590 HTHFIS # PROSITE PS00675 SIGMA54_INTERACT_1 # PROSITE PS00676 SIGMA54_INTERACT_2 # PROSITE PS00688 SIGMA54_INTERACT_3 # PROSITE PS50045 SIGMA54_INTERACT_4 # PROSITE PS50110 RESPONSE_REGULATORY # PTM ZRAR_ECOLI Phosphorylated by ZraS. {ECO 0000269|PubMed 15522865}. # Pfam PF00072 Response_reg # Pfam PF00158 Sigma54_activat # Pfam PF02954 HTH_8 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ZRAR_ECOLI Transcriptional regulatory protein ZraR # RefSeq NP_418432 NC_000913.3 # RefSeq WP_000148503 NZ_LN832404.1 # SIMILARITY Contains 1 response regulatory domain. {ECO:0000255|PROSITE-ProRule PRU00169}. # SIMILARITY Contains 1 sigma-54 factor interaction domain. {ECO:0000255|PROSITE-ProRule PRU00193}. # SMART SM00382 AAA # SMART SM00448 REC # SUBCELLULAR LOCATION ZRAR_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Monomer. {ECO 0000305}. # SUPFAM SSF46689 SSF46689 # SUPFAM SSF52172 SSF52172 # SUPFAM SSF52540 SSF52540 # eggNOG COG2204 LUCA # eggNOG ENOG4105C1W Bacteria BLAST swissprot:ZRAR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ZRAR_ECOLI BioCyc ECOL316407:JW3968-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3968-MONOMER BioCyc EcoCyc:HYDG-MONOMER http://biocyc.org/getid?id=EcoCyc:HYDG-MONOMER COG COG2204 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2204 DIP DIP-9980N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9980N DOI 10.1006/jmbi.2000.4451 http://dx.doi.org/10.1006/jmbi.2000.4451 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M410104200 http://dx.doi.org/10.1074/jbc.M410104200 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M28369 http://www.ebi.ac.uk/ena/data/view/M28369 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0477 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0477 EcoGene EG10482 http://www.ecogene.org/geneInfo.php?eg_id=EG10482 EnsemblBacteria AAC76978 http://www.ensemblgenomes.org/id/AAC76978 EnsemblBacteria AAC76978 http://www.ensemblgenomes.org/id/AAC76978 EnsemblBacteria BAE77315 http://www.ensemblgenomes.org/id/BAE77315 EnsemblBacteria BAE77315 http://www.ensemblgenomes.org/id/BAE77315 EnsemblBacteria BAE77315 http://www.ensemblgenomes.org/id/BAE77315 EnsemblBacteria b4004 http://www.ensemblgenomes.org/id/b4004 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000156 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000156 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948505 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948505 HOGENOM HOG000058487 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000058487&db=HOGENOM6 InParanoid P14375 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P14375 InterPro IPR001789 http://www.ebi.ac.uk/interpro/entry/IPR001789 InterPro IPR002078 http://www.ebi.ac.uk/interpro/entry/IPR002078 InterPro IPR002197 http://www.ebi.ac.uk/interpro/entry/IPR002197 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR011006 http://www.ebi.ac.uk/interpro/entry/IPR011006 InterPro IPR025662 http://www.ebi.ac.uk/interpro/entry/IPR025662 InterPro IPR025943 http://www.ebi.ac.uk/interpro/entry/IPR025943 InterPro IPR025944 http://www.ebi.ac.uk/interpro/entry/IPR025944 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW3968 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3968 KEGG_Gene eco:b4004 http://www.genome.jp/dbget-bin/www_bget?eco:b4004 KEGG_Orthology KO:K07713 http://www.genome.jp/dbget-bin/www_bget?KO:K07713 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA VATDSRW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VATDSRW PRINTS PR01590 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01590 PROSITE PS00675 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00675 PROSITE PS00676 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00676 PROSITE PS00688 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00688 PROSITE PS50045 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50045 PROSITE PS50110 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50110 PSORT swissprot:ZRAR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ZRAR_ECOLI PSORT-B swissprot:ZRAR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ZRAR_ECOLI PSORT2 swissprot:ZRAR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ZRAR_ECOLI Pfam PF00072 http://pfam.xfam.org/family/PF00072 Pfam PF00158 http://pfam.xfam.org/family/PF00158 Pfam PF02954 http://pfam.xfam.org/family/PF02954 Phobius swissprot:ZRAR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ZRAR_ECOLI PhylomeDB P14375 http://phylomedb.org/?seqid=P14375 ProteinModelPortal P14375 http://www.proteinmodelportal.org/query/uniprot/P14375 PubMed 11243806 http://www.ncbi.nlm.nih.gov/pubmed/11243806 PubMed 15522865 http://www.ncbi.nlm.nih.gov/pubmed/15522865 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2666400 http://www.ncbi.nlm.nih.gov/pubmed/2666400 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418432 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418432 RefSeq WP_000148503 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000148503 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMART SM00448 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00448 SMR P14375 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P14375 STRING 511145.b4004 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4004&targetmode=cogs STRING COG2204 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2204&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF52172 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52172 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB ZRAR_ECOLI http://www.uniprot.org/uniprot/ZRAR_ECOLI UniProtKB-AC P14375 http://www.uniprot.org/uniprot/P14375 charge swissprot:ZRAR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ZRAR_ECOLI eggNOG COG2204 http://eggnogapi.embl.de/nog_data/html/tree/COG2204 eggNOG ENOG4105C1W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C1W epestfind swissprot:ZRAR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ZRAR_ECOLI garnier swissprot:ZRAR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ZRAR_ECOLI helixturnhelix swissprot:ZRAR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ZRAR_ECOLI hmoment swissprot:ZRAR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ZRAR_ECOLI iep swissprot:ZRAR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ZRAR_ECOLI inforesidue swissprot:ZRAR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ZRAR_ECOLI octanol swissprot:ZRAR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ZRAR_ECOLI pepcoil swissprot:ZRAR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ZRAR_ECOLI pepdigest swissprot:ZRAR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ZRAR_ECOLI pepinfo swissprot:ZRAR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ZRAR_ECOLI pepnet swissprot:ZRAR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ZRAR_ECOLI pepstats swissprot:ZRAR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ZRAR_ECOLI pepwheel swissprot:ZRAR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ZRAR_ECOLI pepwindow swissprot:ZRAR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ZRAR_ECOLI sigcleave swissprot:ZRAR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ZRAR_ECOLI ## Database ID URL or Descriptions # BioGrid 4260608 9 # DISRUPTION PHENOTYPE PKA_ECOLI Deletion mutant has decreased resistance to oxidative and heat stress. Mutant responds poorly to glucose. {ECO 0000269|PubMed 21696463, ECO 0000269|PubMed 21703240}. # EcoGene EG14224 pka # FUNCTION PKA_ECOLI Acetylates RNase R in exponential phase cells. Also required for the glucose-dependent acetylation on multiple lysines of alpha, beta and beta' RNAP subunits. May acetylate Acs and inhibit its activity. {ECO 0000269|PubMed 21696463, ECO 0000269|PubMed 21981926, ECO 0000269|PubMed 22059728, ECO 0000269|PubMed 22124017}. # GO_function GO:0005524 ATP binding; IEA:InterPro. # GO_function GO:0046872 metal ion binding; IEA:InterPro. # GO_function GO:0048037 cofactor binding; IEA:InterPro. # GO_function GO:0052858 peptidyl-lysine acetyltransferase activity; IMP:EcoliWiki. # GO_function GO:0061733 peptide-lysine-N-acetyltransferase activity; IDA:EcoCyc. # GO_process GO:0006979 response to oxidative stress; IMP:EcoCyc. # GO_process GO:0009408 response to heat; IMP:EcoCyc. # GO_process GO:0018393 internal peptidyl-lysine acetylation; IDA:EcoCyc. # GO_process GO:0032462 regulation of protein homooligomerization; IDA:EcoCyc. # GO_process GO:0051289 protein homotetramerization; IDA:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # Gene3D 3.30.470.20 -; 1. # Gene3D 3.40.50.261 -; 2. # Gene3D 3.40.50.720 -; 1. # Gene3D 3.40.630.30 -; 1. # INDUCTION PKA_ECOLI Positively regulated by cAMP-CRP. Up-regulated in the presence of non-PTS carbon sources (PubMed 22059728). According to PubMed 22059728, pka is up-regulated during the stationary phase growth, while according to PubMed 22124017, it is absent from the late exponential and stationary phase cells. {ECO 0000269|PubMed 22059728, ECO 0000269|PubMed 22124017}. # INTERACTION PKA_ECOLI P77802 ecpC; NbExp=4; IntAct=EBI-557388, EBI-561348; # IntAct P76594 29 # InterPro IPR000182 GNAT_dom # InterPro IPR003781 CoA-bd # InterPro IPR011761 ATP-grasp # InterPro IPR013816 ATP_grasp_subdomain_2 # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR016102 Succinyl-CoA_synth-like # InterPro IPR016181 Acyl_CoA_acyltransferase # InterPro IPR032875 Succ_CoA_lig_flav_dom # Organism PKA_ECOLI Escherichia coli (strain K12) # PATRIC 32120569 VBIEscCol129921_2687 # PIR G65036 G65036 # PROSITE PS50975 ATP_GRASP # PROSITE PS51186 GNAT # Pfam PF00583 Acetyltransf_1 # Pfam PF13380 CoA_binding_2 # Pfam PF13607 Succ_CoA_lig # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PKA_ECOLI Protein lysine acetyltransferase Pka # RefSeq NP_417079 NC_000913.3 # RefSeq WP_000083005 NZ_LN832404.1 # SIMILARITY Contains 1 ATP-grasp domain. {ECO:0000255|PROSITE- ProRule PRU00409}. # SIMILARITY Contains 1 N-acetyltransferase domain. {ECO:0000255|PROSITE-ProRule PRU00532}. # SIMILARITY In the N-terminal section; belongs to the acetate CoA ligase alpha subunit family. {ECO 0000305}. # SIMILARITY In the central section; belongs to the acetate CoA ligase beta subunit family. {ECO 0000305}. # SMART SM00881 CoA_binding # SUPFAM SSF51735 SSF51735 # SUPFAM SSF52210 SSF52210; 2 # SUPFAM SSF55729 SSF55729 # eggNOG COG0454 LUCA # eggNOG COG1042 LUCA # eggNOG ENOG4105CD5 Bacteria BLAST swissprot:PKA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PKA_ECOLI BioCyc ECOL316407:JW2568-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2568-MONOMER BioCyc EcoCyc:G7350-MONOMER http://biocyc.org/getid?id=EcoCyc:G7350-MONOMER BioCyc MetaCyc:G7350-MONOMER http://biocyc.org/getid?id=MetaCyc:G7350-MONOMER DIP DIP-12068N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12068N DOI 10.1016/j.bbrc.2011.06.076 http://dx.doi.org/10.1016/j.bbrc.2011.06.076 DOI 10.1016/j.molcel.2011.06.037 http://dx.doi.org/10.1016/j.molcel.2011.06.037 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2011.07742.x http://dx.doi.org/10.1111/j.1365-2958.2011.07742.x DOI 10.1111/j.1365-2958.2011.07873.x http://dx.doi.org/10.1111/j.1365-2958.2011.07873.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1261/rna.030213.111 http://dx.doi.org/10.1261/rna.030213.111 EC_number EC:2.3.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D64044 http://www.ebi.ac.uk/ena/data/view/D64044 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.3.1.- http://enzyme.expasy.org/EC/2.3.1.- EchoBASE EB3976 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3976 EcoGene EG14224 http://www.ecogene.org/geneInfo.php?eg_id=EG14224 EnsemblBacteria AAC75637 http://www.ensemblgenomes.org/id/AAC75637 EnsemblBacteria AAC75637 http://www.ensemblgenomes.org/id/AAC75637 EnsemblBacteria BAE76754 http://www.ensemblgenomes.org/id/BAE76754 EnsemblBacteria BAE76754 http://www.ensemblgenomes.org/id/BAE76754 EnsemblBacteria BAE76754 http://www.ensemblgenomes.org/id/BAE76754 EnsemblBacteria b2584 http://www.ensemblgenomes.org/id/b2584 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0048037 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048037 GO_function GO:0052858 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052858 GO_function GO:0061733 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061733 GO_process GO:0006979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GO_process GO:0018393 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018393 GO_process GO:0032462 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032462 GO_process GO:0051289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051289 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.30.470.20 http://www.cathdb.info/version/latest/superfamily/3.30.470.20 Gene3D 3.40.50.261 http://www.cathdb.info/version/latest/superfamily/3.40.50.261 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 Gene3D 3.40.630.30 http://www.cathdb.info/version/latest/superfamily/3.40.630.30 GeneID 947056 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947056 HOGENOM HOG000220090 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220090&db=HOGENOM6 InParanoid P76594 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76594 IntAct P76594 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76594* IntEnz 2.3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1 InterPro IPR000182 http://www.ebi.ac.uk/interpro/entry/IPR000182 InterPro IPR003781 http://www.ebi.ac.uk/interpro/entry/IPR003781 InterPro IPR011761 http://www.ebi.ac.uk/interpro/entry/IPR011761 InterPro IPR013816 http://www.ebi.ac.uk/interpro/entry/IPR013816 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR016102 http://www.ebi.ac.uk/interpro/entry/IPR016102 InterPro IPR016181 http://www.ebi.ac.uk/interpro/entry/IPR016181 InterPro IPR032875 http://www.ebi.ac.uk/interpro/entry/IPR032875 KEGG_Gene ecj:JW2568 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2568 KEGG_Gene eco:b2584 http://www.genome.jp/dbget-bin/www_bget?eco:b2584 KEGG_Orthology KO:K09181 http://www.genome.jp/dbget-bin/www_bget?KO:K09181 MINT MINT-1243710 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1243710 OMA IVIYMES http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IVIYMES PROSITE PS50975 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50975 PROSITE PS51186 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51186 PSORT swissprot:PKA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PKA_ECOLI PSORT-B swissprot:PKA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PKA_ECOLI PSORT2 swissprot:PKA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PKA_ECOLI Pfam PF00583 http://pfam.xfam.org/family/PF00583 Pfam PF13380 http://pfam.xfam.org/family/PF13380 Pfam PF13607 http://pfam.xfam.org/family/PF13607 Phobius swissprot:PKA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PKA_ECOLI PhylomeDB P76594 http://phylomedb.org/?seqid=P76594 ProteinModelPortal P76594 http://www.proteinmodelportal.org/query/uniprot/P76594 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21696463 http://www.ncbi.nlm.nih.gov/pubmed/21696463 PubMed 21703240 http://www.ncbi.nlm.nih.gov/pubmed/21703240 PubMed 21981926 http://www.ncbi.nlm.nih.gov/pubmed/21981926 PubMed 22059728 http://www.ncbi.nlm.nih.gov/pubmed/22059728 PubMed 22124017 http://www.ncbi.nlm.nih.gov/pubmed/22124017 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417079 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417079 RefSeq WP_000083005 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000083005 SMART SM00881 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00881 SMR P76594 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76594 STRING 511145.b2584 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2584&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 SUPFAM SSF52210 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52210 SUPFAM SSF55729 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55729 UniProtKB PKA_ECOLI http://www.uniprot.org/uniprot/PKA_ECOLI UniProtKB-AC P76594 http://www.uniprot.org/uniprot/P76594 charge swissprot:PKA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PKA_ECOLI eggNOG COG0454 http://eggnogapi.embl.de/nog_data/html/tree/COG0454 eggNOG COG1042 http://eggnogapi.embl.de/nog_data/html/tree/COG1042 eggNOG ENOG4105CD5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CD5 epestfind swissprot:PKA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PKA_ECOLI garnier swissprot:PKA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PKA_ECOLI helixturnhelix swissprot:PKA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PKA_ECOLI hmoment swissprot:PKA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PKA_ECOLI iep swissprot:PKA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PKA_ECOLI inforesidue swissprot:PKA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PKA_ECOLI octanol swissprot:PKA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PKA_ECOLI pepcoil swissprot:PKA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PKA_ECOLI pepdigest swissprot:PKA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PKA_ECOLI pepinfo swissprot:PKA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PKA_ECOLI pepnet swissprot:PKA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PKA_ECOLI pepstats swissprot:PKA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PKA_ECOLI pepwheel swissprot:PKA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PKA_ECOLI pepwindow swissprot:PKA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PKA_ECOLI sigcleave swissprot:PKA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PKA_ECOLI ## Database ID URL or Descriptions # AltName LPIV_ECOLI IlvBN operon attenuator peptide # BioGrid 4259302 2 # EcoGene EG11275 ivbL # FUNCTION LPIV_ECOLI This protein is involved in control of the biosynthesis of isoleucine, leucine, and valine. # GO_process GO:0009082 branched-chain amino acid biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0009099 valine biosynthetic process; IMP:EcoCyc. # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # InterPro IPR012566 IlvB_leader # Organism LPIV_ECOLI Escherichia coli (strain K12) # PIR A03597 LFECIV # Pfam PF08049 IlvB_leader # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LPIV_ECOLI IlvBN operon leader peptide # RefSeq NP_418128 NC_000913.3 # RefSeq WP_001300753 NZ_LN832404.1 BLAST swissprot:LPIV_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LPIV_ECOLI BioCyc ECOL316407:JW3647-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3647-MONOMER BioCyc EcoCyc:EG11275-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11275-MONOMER DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.79.20.6156 http://dx.doi.org/10.1073/pnas.79.20.6156 DOI 10.1093/nar/13.11.3995 http://dx.doi.org/10.1093/nar/13.11.3995 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X02541 http://www.ebi.ac.uk/ena/data/view/X02541 EchoBASE EB1253 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1253 EcoGene EG11275 http://www.ecogene.org/geneInfo.php?eg_id=EG11275 EnsemblBacteria AAC76695 http://www.ensemblgenomes.org/id/AAC76695 EnsemblBacteria AAC76695 http://www.ensemblgenomes.org/id/AAC76695 EnsemblBacteria BAE77621 http://www.ensemblgenomes.org/id/BAE77621 EnsemblBacteria BAE77621 http://www.ensemblgenomes.org/id/BAE77621 EnsemblBacteria BAE77621 http://www.ensemblgenomes.org/id/BAE77621 EnsemblBacteria b3672 http://www.ensemblgenomes.org/id/b3672 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0009082 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009082 GO_process GO:0009099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009099 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 948181 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948181 InterPro IPR012566 http://www.ebi.ac.uk/interpro/entry/IPR012566 KEGG_Gene ecj:JW3647 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3647 KEGG_Gene eco:b3672 http://www.genome.jp/dbget-bin/www_bget?eco:b3672 PSORT swissprot:LPIV_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LPIV_ECOLI PSORT-B swissprot:LPIV_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LPIV_ECOLI PSORT2 swissprot:LPIV_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LPIV_ECOLI Pfam PF08049 http://pfam.xfam.org/family/PF08049 Phobius swissprot:LPIV_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LPIV_ECOLI ProteinModelPortal P03061 http://www.proteinmodelportal.org/query/uniprot/P03061 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2989782 http://www.ncbi.nlm.nih.gov/pubmed/2989782 PubMed 6292893 http://www.ncbi.nlm.nih.gov/pubmed/6292893 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418128 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418128 RefSeq WP_001300753 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300753 STRING 511145.b3672 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3672&targetmode=cogs UniProtKB LPIV_ECOLI http://www.uniprot.org/uniprot/LPIV_ECOLI UniProtKB-AC P03061 http://www.uniprot.org/uniprot/P03061 charge swissprot:LPIV_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LPIV_ECOLI epestfind swissprot:LPIV_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LPIV_ECOLI garnier swissprot:LPIV_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LPIV_ECOLI helixturnhelix swissprot:LPIV_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LPIV_ECOLI hmoment swissprot:LPIV_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LPIV_ECOLI iep swissprot:LPIV_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LPIV_ECOLI inforesidue swissprot:LPIV_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LPIV_ECOLI octanol swissprot:LPIV_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LPIV_ECOLI pepcoil swissprot:LPIV_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LPIV_ECOLI pepdigest swissprot:LPIV_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LPIV_ECOLI pepinfo swissprot:LPIV_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LPIV_ECOLI pepnet swissprot:LPIV_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LPIV_ECOLI pepstats swissprot:LPIV_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LPIV_ECOLI pepwheel swissprot:LPIV_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LPIV_ECOLI pepwindow swissprot:LPIV_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LPIV_ECOLI sigcleave swissprot:LPIV_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LPIV_ECOLI ## Database ID URL or Descriptions # BioGrid 4259850 4 # CATALYTIC ACTIVITY INGK_ECOLI ATP + inosine = ADP + IMP. # EcoGene EG11102 gsk # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0008906 inosine kinase activity; IDA:EcoCyc. # GO_process GO:0032264 IMP salvage; IEA:UniProtKB-UniPathway. # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.1190.20 -; 2. # INTERACTION INGK_ECOLI P75767 ybhK; NbExp=4; IntAct=EBI-548746, EBI-550390; # IntAct P0AEW6 9 # InterPro IPR002173 Carboh/pur_kinase_PfkB_CS # InterPro IPR011611 PfkB_dom # InterPro IPR029056 Ribokinase-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # Organism INGK_ECOLI Escherichia coli (strain K12) # PATHWAY Purine metabolism; IMP biosynthesis via salvage pathway; IMP from inosine step 1/1. # PATRIC 32116111 VBIEscCol129921_0497 # PIR JQ0812 JQ0812 # PROSITE PS00584 PFKB_KINASES_2 # Pfam PF00294 PfkB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INGK_ECOLI Inosine-guanosine kinase # RefSeq NP_415010 NC_000913.3 # RefSeq WP_000671574 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA14306.1; Type=Frameshift; Positions=281; Evidence={ECO 0000305}; # SIMILARITY Belongs to the carbohydrate kinase PfkB family. {ECO 0000305}. # SUPFAM SSF53613 SSF53613; 2 # UniPathway UPA00591 UER00647 # eggNOG COG0524 LUCA # eggNOG ENOG4107RE1 Bacteria BLAST swissprot:INGK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INGK_ECOLI BioCyc ECOL316407:JW0466-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0466-MONOMER BioCyc EcoCyc:GSK-MONOMER http://biocyc.org/getid?id=EcoCyc:GSK-MONOMER BioCyc MetaCyc:GSK-MONOMER http://biocyc.org/getid?id=MetaCyc:GSK-MONOMER COG COG0524 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0524 DIP DIP-48148N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48148N DOI 10.1016/0022-2836(91)90180-E http://dx.doi.org/10.1016/0022-2836(91)90180-E DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.73 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.73 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D00798 http://www.ebi.ac.uk/ena/data/view/D00798 EMBL D90259 http://www.ebi.ac.uk/ena/data/view/D90259 EMBL L35149 http://www.ebi.ac.uk/ena/data/view/L35149 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 ENZYME 2.7.1.73 http://enzyme.expasy.org/EC/2.7.1.73 EchoBASE EB1094 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1094 EcoGene EG11102 http://www.ecogene.org/geneInfo.php?eg_id=EG11102 EnsemblBacteria AAC73579 http://www.ensemblgenomes.org/id/AAC73579 EnsemblBacteria AAC73579 http://www.ensemblgenomes.org/id/AAC73579 EnsemblBacteria BAE76256 http://www.ensemblgenomes.org/id/BAE76256 EnsemblBacteria BAE76256 http://www.ensemblgenomes.org/id/BAE76256 EnsemblBacteria BAE76256 http://www.ensemblgenomes.org/id/BAE76256 EnsemblBacteria b0477 http://www.ensemblgenomes.org/id/b0477 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008906 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008906 GO_process GO:0032264 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032264 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.1190.20 http://www.cathdb.info/version/latest/superfamily/3.40.1190.20 GeneID 946584 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946584 HOGENOM HOG000278653 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278653&db=HOGENOM6 InParanoid P0AEW6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEW6 IntAct P0AEW6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEW6* IntEnz 2.7.1.73 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.73 InterPro IPR002173 http://www.ebi.ac.uk/interpro/entry/IPR002173 InterPro IPR011611 http://www.ebi.ac.uk/interpro/entry/IPR011611 InterPro IPR029056 http://www.ebi.ac.uk/interpro/entry/IPR029056 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0466 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0466 KEGG_Gene eco:b0477 http://www.genome.jp/dbget-bin/www_bget?eco:b0477 KEGG_Orthology KO:K00892 http://www.genome.jp/dbget-bin/www_bget?KO:K00892 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Reaction rn:R01131 http://www.genome.jp/dbget-bin/www_bget?rn:R01131 KEGG_Reaction rn:R01228 http://www.genome.jp/dbget-bin/www_bget?rn:R01228 MINT MINT-1264409 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1264409 OMA LLGVMCN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LLGVMCN PROSITE PS00584 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00584 PSORT swissprot:INGK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INGK_ECOLI PSORT-B swissprot:INGK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INGK_ECOLI PSORT2 swissprot:INGK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INGK_ECOLI Pfam PF00294 http://pfam.xfam.org/family/PF00294 Phobius swissprot:INGK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INGK_ECOLI PhylomeDB P0AEW6 http://phylomedb.org/?seqid=P0AEW6 ProteinModelPortal P0AEW6 http://www.proteinmodelportal.org/query/uniprot/P0AEW6 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2051480 http://www.ncbi.nlm.nih.gov/pubmed/2051480 PubMed 7665468 http://www.ncbi.nlm.nih.gov/pubmed/7665468 PubMed 7721718 http://www.ncbi.nlm.nih.gov/pubmed/7721718 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415010 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415010 RefSeq WP_000671574 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000671574 STRING 511145.b0477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0477&targetmode=cogs STRING COG0524 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0524&targetmode=cogs SUPFAM SSF53613 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53613 UniProtKB INGK_ECOLI http://www.uniprot.org/uniprot/INGK_ECOLI UniProtKB-AC P0AEW6 http://www.uniprot.org/uniprot/P0AEW6 charge swissprot:INGK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INGK_ECOLI eggNOG COG0524 http://eggnogapi.embl.de/nog_data/html/tree/COG0524 eggNOG ENOG4107RE1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107RE1 epestfind swissprot:INGK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INGK_ECOLI garnier swissprot:INGK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INGK_ECOLI helixturnhelix swissprot:INGK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INGK_ECOLI hmoment swissprot:INGK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INGK_ECOLI iep swissprot:INGK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INGK_ECOLI inforesidue swissprot:INGK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INGK_ECOLI octanol swissprot:INGK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INGK_ECOLI pepcoil swissprot:INGK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INGK_ECOLI pepdigest swissprot:INGK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INGK_ECOLI pepinfo swissprot:INGK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INGK_ECOLI pepnet swissprot:INGK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INGK_ECOLI pepstats swissprot:INGK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INGK_ECOLI pepwheel swissprot:INGK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INGK_ECOLI pepwindow swissprot:INGK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INGK_ECOLI sigcleave swissprot:INGK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INGK_ECOLI ## Database ID URL or Descriptions # AltName Cytidine 5'-triphosphate synthase {ECO:0000303|PubMed 11336655} # AltName Cytidine triphosphate synthetase {ECO:0000303|PubMed 15157079} # AltName PYRG_ECOLI UTP--ammonia ligase # BIOPHYSICOCHEMICAL PROPERTIES PYRG_ECOLI Kinetic parameters KM=2.0 mM for ammonia {ECO 0000269|PubMed 11336655}; KM=0.30 mM for L-glutamine (in the presence of 0.25 mM GTP) {ECO 0000269|PubMed 11336655}; Note=kcat is 13 sec(-1) with ammonia as substrate. kcat is 6.6 sec(-1) with L-glutamine as substrate (in the presence of 0.25 mM GTP). {ECO 0000269|PubMed 11336655}; pH dependence Optimum pH is 8.7. {ECO 0000269|PubMed 8385490}; # BRENDA 6.3.4 2026 # CATALYTIC ACTIVITY PYRG_ECOLI ATP + UTP + L-glutamine = ADP + phosphate + CTP + L-glutamate. {ECO 0000269|PubMed 11336655, ECO 0000269|PubMed 4550559, ECO 0000269|PubMed 8385490}. # CDD cd01746 GATase1_CTP_Synthase # DOMAIN PYRG_ECOLI Sequence consists of two domains the C-terminal glutamine amide transfer (GAT) domain catalyzes the hydrolysis of glutamine; the N-terminal synthase domain catalyzes the amination of UTP (PubMed 3514618, PubMed 3298209). Structure shows each subunit consists of three distinct segments the N-terminal amidoligase (ALase) domain, which mediates oligomerization and contains the ALase active site where ATP and UTP substrates bind, and an interrupted helical interdomain linker segment that connects the ALase domain to the Type I glutamine amidotransferase (GATase) C- terminal domain, which generates ammonia via glutamine hydrolysis (PubMed 15157079). A gated channel that spans 25 Angstroms between the glutamine hydrolysis and amidoligase active sites provides a path for ammonia diffusion; the channel is accessible to solvent at the base of a cleft adjoining the glutamine hydrolysis active site, providing an entry point for exogenous ammonia (PubMed 15157079). {ECO 0000305|PubMed 15157079, ECO 0000305|PubMed 3298209, ECO 0000305|PubMed 3514618}. # ENZYME REGULATION PYRG_ECOLI Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate (PubMed 4550559). The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis (PubMed 11336655). Also activated by magnesium; the enzyme requires more Mg(2+) for full catalytic activity than required simply to complex the nucleotide substrates (PubMed 8385490). Inhibited by the product CTP, via allosteric rather than competitive inhibition (PubMed 8385490, PubMed 16216072). Also inhibited by divalent metal ions such as copper and zinc (PubMed 8385490). Is potently inhibited by the intermediate analog inhibitor glutamate gamma-semialdehyde (PubMed 11336655). {ECO 0000269|PubMed 11336655, ECO 0000269|PubMed 4550559, ECO 0000269|PubMed 8385490, ECO 0000305|PubMed 16216072}. # EcoGene EG10810 pyrG # FUNCTION PYRG_ECOLI Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. {ECO 0000269|PubMed 11336655, ECO 0000269|PubMed 8385490, ECO 0000305|PubMed 15157079}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0003883 CTP synthase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006241 CTP biosynthetic process; IDA:EcoCyc. # GO_process GO:0006541 glutamine metabolic process; IEA:UniProtKB-HAMAP. # GO_process GO:0044210 'de novo' CTP biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.300 -; 1. # Gene3D 3.40.50.880 -; 1. # HAMAP MF_01227 PyrG # IntAct P0A7E5 8 # InterPro IPR004468 CTP_synthase # InterPro IPR017456 CTP_synthase_N # InterPro IPR017926 GATASE # InterPro IPR027417 P-loop_NTPase # InterPro IPR029062 Class_I_gatase-like # InterPro IPR033828 GATase1_CTP_Synthase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00240 Pyrimidine metabolism # MISCELLANEOUS CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor. {ECO:0000305|PubMed 16216072}. # Organism PYRG_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11550 PTHR11550 # PATHWAY Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2. {ECO 0000255|HAMAP- Rule:MF_01227}. # PATRIC 32120976 VBIEscCol129921_2880 # PDB 1S1M X-ray; 2.30 A; A/B=1-545 # PDB 2AD5 X-ray; 2.80 A; A/B=1-545 # PIR H65059 SYECTP # PROSITE PS51273 GATASE_TYPE_1 # Pfam PF00117 GATase # Pfam PF06418 CTP_synth_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CTP synthase {ECO:0000303|PubMed 11336655} # RefSeq NP_417260 NC_000913.3 # RefSeq WP_000210878 NZ_LN832404.1 # SIMILARITY Belongs to the CTP synthase family. {ECO:0000255|HAMAP-Rule MF_01227}. # SIMILARITY Contains 1 glutamine amidotransferase type-1 domain. {ECO:0000255|HAMAP-Rule MF_01227}. # SUBUNIT Homodimer that associates to form homotetramer in the presence of ATP and UTP. The substrate nucleotides ATP and UTP act synergistically to promote oligomerization of CTPS from inactive dimers to active tetramers. {ECO:0000269|PubMed 4550560}. # SUPFAM SSF52317 SSF52317 # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR00337 PyrG # UniPathway UPA00159 UER00277 # eggNOG COG0504 LUCA # eggNOG ENOG4105C8D Bacteria BLAST swissprot:PYRG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PYRG_ECOLI BioCyc ECOL316407:JW2751-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2751-MONOMER BioCyc EcoCyc:CTPSYN-MONOMER http://biocyc.org/getid?id=EcoCyc:CTPSYN-MONOMER BioCyc MetaCyc:CTPSYN-MONOMER http://biocyc.org/getid?id=MetaCyc:CTPSYN-MONOMER COG COG0504 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0504 DIP DIP-10628N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10628N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1021/bi00065a032 http://dx.doi.org/10.1021/bi00065a032 DOI 10.1021/bi00752a015 http://dx.doi.org/10.1021/bi00752a015 DOI 10.1021/bi00752a016 http://dx.doi.org/10.1021/bi00752a016 DOI 10.1021/bi0496945 http://dx.doi.org/10.1021/bi0496945 DOI 10.1021/bi051282o http://dx.doi.org/10.1021/bi051282o DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/0264-6021:3560223 http://dx.doi.org/10.1042/0264-6021:3560223 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.3.4.2 {ECO:0000269|PubMed:11336655, ECO:0000269|PubMed:4550559, ECO:0000269|PubMed:8385490} http://www.genome.jp/dbget-bin/www_bget?EC:6.3.4.2 {ECO:0000269|PubMed:11336655, ECO:0000269|PubMed:4550559, ECO:0000269|PubMed:8385490} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M12843 http://www.ebi.ac.uk/ena/data/view/M12843 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29580 http://www.ebi.ac.uk/ena/data/view/U29580 ENZYME 6.3.4.2 {ECO:0000269|PubMed:11336655, ECO:0000269|PubMed:4550559, ECO:0000269|PubMed:8385490} http://enzyme.expasy.org/EC/6.3.4.2 {ECO:0000269|PubMed:11336655, ECO:0000269|PubMed:4550559, ECO:0000269|PubMed:8385490} EchoBASE EB0803 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0803 EcoGene EG10810 http://www.ecogene.org/geneInfo.php?eg_id=EG10810 EnsemblBacteria AAC75822 http://www.ensemblgenomes.org/id/AAC75822 EnsemblBacteria AAC75822 http://www.ensemblgenomes.org/id/AAC75822 EnsemblBacteria BAE76854 http://www.ensemblgenomes.org/id/BAE76854 EnsemblBacteria BAE76854 http://www.ensemblgenomes.org/id/BAE76854 EnsemblBacteria BAE76854 http://www.ensemblgenomes.org/id/BAE76854 EnsemblBacteria b2780 http://www.ensemblgenomes.org/id/b2780 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003883 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003883 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006241 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006241 GO_process GO:0006541 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006541 GO_process GO:0044210 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044210 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 Gene3D 3.40.50.880 http://www.cathdb.info/version/latest/superfamily/3.40.50.880 GeneID 946116 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946116 HAMAP MF_01227 http://hamap.expasy.org/unirule/MF_01227 HOGENOM HOG000077515 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000077515&db=HOGENOM6 InParanoid P0A7E5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7E5 IntAct P0A7E5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7E5* IntEnz 6.3.4.2 {ECO:0000269|PubMed:11336655, ECO:0000269|PubMed:4550559, ECO:0000269|PubMed:8385490} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.4.2 {ECO:0000269|PubMed:11336655, ECO:0000269|PubMed:4550559, ECO:0000269|PubMed:8385490} InterPro IPR004468 http://www.ebi.ac.uk/interpro/entry/IPR004468 InterPro IPR017456 http://www.ebi.ac.uk/interpro/entry/IPR017456 InterPro IPR017926 http://www.ebi.ac.uk/interpro/entry/IPR017926 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR029062 http://www.ebi.ac.uk/interpro/entry/IPR029062 InterPro IPR033828 http://www.ebi.ac.uk/interpro/entry/IPR033828 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2751 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2751 KEGG_Gene eco:b2780 http://www.genome.jp/dbget-bin/www_bget?eco:b2780 KEGG_Orthology KO:K01937 http://www.genome.jp/dbget-bin/www_bget?KO:K01937 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Reaction rn:R00571 http://www.genome.jp/dbget-bin/www_bget?rn:R00571 KEGG_Reaction rn:R00573 http://www.genome.jp/dbget-bin/www_bget?rn:R00573 OMA TMRLGEY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TMRLGEY PANTHER PTHR11550 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11550 PDB 1S1M http://www.ebi.ac.uk/pdbe-srv/view/entry/1S1M PDB 2AD5 http://www.ebi.ac.uk/pdbe-srv/view/entry/2AD5 PDBsum 1S1M http://www.ebi.ac.uk/pdbsum/1S1M PDBsum 2AD5 http://www.ebi.ac.uk/pdbsum/2AD5 PROSITE PS51273 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51273 PSORT swissprot:PYRG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PYRG_ECOLI PSORT-B swissprot:PYRG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PYRG_ECOLI PSORT2 swissprot:PYRG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PYRG_ECOLI Pfam PF00117 http://pfam.xfam.org/family/PF00117 Pfam PF06418 http://pfam.xfam.org/family/PF06418 Phobius swissprot:PYRG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PYRG_ECOLI PhylomeDB P0A7E5 http://phylomedb.org/?seqid=P0A7E5 ProteinModelPortal P0A7E5 http://www.proteinmodelportal.org/query/uniprot/P0A7E5 PubMed 11336655 http://www.ncbi.nlm.nih.gov/pubmed/11336655 PubMed 15157079 http://www.ncbi.nlm.nih.gov/pubmed/15157079 PubMed 16216072 http://www.ncbi.nlm.nih.gov/pubmed/16216072 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3298209 http://www.ncbi.nlm.nih.gov/pubmed/3298209 PubMed 3514618 http://www.ncbi.nlm.nih.gov/pubmed/3514618 PubMed 4550559 http://www.ncbi.nlm.nih.gov/pubmed/4550559 PubMed 4550560 http://www.ncbi.nlm.nih.gov/pubmed/4550560 PubMed 8385490 http://www.ncbi.nlm.nih.gov/pubmed/8385490 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_417260 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417260 RefSeq WP_000210878 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000210878 SMR P0A7E5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7E5 STRING 511145.b2780 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2780&targetmode=cogs STRING COG0504 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0504&targetmode=cogs SUPFAM SSF52317 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52317 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SWISS-2DPAGE P0A7E5 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A7E5 TIGRFAMs TIGR00337 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00337 UniProtKB PYRG_ECOLI http://www.uniprot.org/uniprot/PYRG_ECOLI UniProtKB-AC P0A7E5 http://www.uniprot.org/uniprot/P0A7E5 charge swissprot:PYRG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PYRG_ECOLI eggNOG COG0504 http://eggnogapi.embl.de/nog_data/html/tree/COG0504 eggNOG ENOG4105C8D http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C8D epestfind swissprot:PYRG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PYRG_ECOLI garnier swissprot:PYRG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PYRG_ECOLI helixturnhelix swissprot:PYRG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PYRG_ECOLI hmoment swissprot:PYRG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PYRG_ECOLI iep swissprot:PYRG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PYRG_ECOLI inforesidue swissprot:PYRG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PYRG_ECOLI octanol swissprot:PYRG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PYRG_ECOLI pepcoil swissprot:PYRG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PYRG_ECOLI pepdigest swissprot:PYRG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PYRG_ECOLI pepinfo swissprot:PYRG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PYRG_ECOLI pepnet swissprot:PYRG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PYRG_ECOLI pepstats swissprot:PYRG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PYRG_ECOLI pepwheel swissprot:PYRG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PYRG_ECOLI pepwindow swissprot:PYRG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PYRG_ECOLI sigcleave swissprot:PYRG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PYRG_ECOLI ## Database ID URL or Descriptions # AltName RLMA_ECOLI 23S rRNA m1G745 methyltransferase # AltName RLMA_ECOLI Ribosomal RNA large subunit methyltransferase A # BRENDA 2.1.1.187 2026 # BioGrid 4260324 2 # CATALYTIC ACTIVITY S-adenosyl-L-methionine + guanine(745) in 23S rRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(745) in 23S rRNA. {ECO:0000269|PubMed 9440525}. # EcoGene EG12207 rlmA # FUNCTION RLMA_ECOLI Specifically methylates the guanosine in position 745 of 23S rRNA. {ECO 0000269|PubMed 9440525}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_function GO:0008989 rRNA (guanine-N1-)-methyltransferase activity; IDA:EcoCyc. # GO_function GO:0052911 23S rRNA (guanine(745)-N(1))-methyltransferase activity; IEA:UniProtKB-EC. # GO_process GO:0070475 rRNA base methylation; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0008168 methyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.50.150 -; 1. # IntAct P36999 18 # InterPro IPR016718 rRNA_m1G-MeTrfase_A_prd # InterPro IPR025714 Methyltranfer_dom # InterPro IPR029063 SAM-dependent_MTases # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # Organism RLMA_ECOLI Escherichia coli (strain K12) # PATRIC 32118963 VBIEscCol129921_1899 # PDB 1P91 X-ray; 2.80 A; A/B=1-269 # PIR S49049 S49049 # PIRSF PIRSF018249 MyrA_prd # Pfam PF13847 Methyltransf_31 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RLMA_ECOLI 23S rRNA (guanine(745)-N(1))-methyltransferase # RefSeq NP_416336 NC_000913.3 # RefSeq WP_000010115 NZ_LN832404.1 # SIMILARITY Belongs to the methyltransferase superfamily. RlmA family. {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 14999102}. # SUPFAM SSF53335 SSF53335 # eggNOG COG0500 LUCA # eggNOG ENOG4105DHI Bacteria BLAST swissprot:RLMA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RLMA_ECOLI BioCyc ECOL316407:JW1811-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1811-MONOMER BioCyc EcoCyc:EG12207-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12207-MONOMER BioCyc MetaCyc:EG12207-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12207-MONOMER COG COG0500 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0500 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0400189101 http://dx.doi.org/10.1073/pnas.0400189101 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1111/j.1365-2958.1994.tb00424.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb00424.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.1.187 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.187 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D28496 http://www.ebi.ac.uk/ena/data/view/D28496 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.1.1.187 http://enzyme.expasy.org/EC/2.1.1.187 EchoBASE EB2122 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2122 EcoGene EG12207 http://www.ecogene.org/geneInfo.php?eg_id=EG12207 EnsemblBacteria AAC74892 http://www.ensemblgenomes.org/id/AAC74892 EnsemblBacteria AAC74892 http://www.ensemblgenomes.org/id/AAC74892 EnsemblBacteria BAA15633 http://www.ensemblgenomes.org/id/BAA15633 EnsemblBacteria BAA15633 http://www.ensemblgenomes.org/id/BAA15633 EnsemblBacteria BAA15633 http://www.ensemblgenomes.org/id/BAA15633 EnsemblBacteria b1822 http://www.ensemblgenomes.org/id/b1822 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0008989 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008989 GO_function GO:0052911 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052911 GO_process GO:0070475 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070475 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 GeneID 946340 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946340 HOGENOM HOG000040121 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000040121&db=HOGENOM6 InParanoid P36999 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P36999 IntAct P36999 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P36999* IntEnz 2.1.1.187 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.187 InterPro IPR016718 http://www.ebi.ac.uk/interpro/entry/IPR016718 InterPro IPR025714 http://www.ebi.ac.uk/interpro/entry/IPR025714 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW1811 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1811 KEGG_Gene eco:b1822 http://www.genome.jp/dbget-bin/www_bget?eco:b1822 KEGG_Orthology KO:K00563 http://www.genome.jp/dbget-bin/www_bget?KO:K00563 KEGG_Reaction rn:R07233 http://www.genome.jp/dbget-bin/www_bget?rn:R07233 OMA VQHKHSK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VQHKHSK PDB 1P91 http://www.ebi.ac.uk/pdbe-srv/view/entry/1P91 PDBsum 1P91 http://www.ebi.ac.uk/pdbsum/1P91 PSORT swissprot:RLMA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RLMA_ECOLI PSORT-B swissprot:RLMA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RLMA_ECOLI PSORT2 swissprot:RLMA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RLMA_ECOLI Pfam PF13847 http://pfam.xfam.org/family/PF13847 Phobius swissprot:RLMA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RLMA_ECOLI PhylomeDB P36999 http://phylomedb.org/?seqid=P36999 ProteinModelPortal P36999 http://www.proteinmodelportal.org/query/uniprot/P36999 PubMed 14999102 http://www.ncbi.nlm.nih.gov/pubmed/14999102 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7984109 http://www.ncbi.nlm.nih.gov/pubmed/7984109 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9440525 http://www.ncbi.nlm.nih.gov/pubmed/9440525 RefSeq NP_416336 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416336 RefSeq WP_000010115 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000010115 SMR P36999 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P36999 STRING 511145.b1822 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1822&targetmode=cogs STRING COG0500 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0500&targetmode=cogs SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 UniProtKB RLMA_ECOLI http://www.uniprot.org/uniprot/RLMA_ECOLI UniProtKB-AC P36999 http://www.uniprot.org/uniprot/P36999 charge swissprot:RLMA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RLMA_ECOLI eggNOG COG0500 http://eggnogapi.embl.de/nog_data/html/tree/COG0500 eggNOG ENOG4105DHI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DHI epestfind swissprot:RLMA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RLMA_ECOLI garnier swissprot:RLMA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RLMA_ECOLI helixturnhelix swissprot:RLMA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RLMA_ECOLI hmoment swissprot:RLMA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RLMA_ECOLI iep swissprot:RLMA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RLMA_ECOLI inforesidue swissprot:RLMA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RLMA_ECOLI octanol swissprot:RLMA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RLMA_ECOLI pepcoil swissprot:RLMA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RLMA_ECOLI pepdigest swissprot:RLMA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RLMA_ECOLI pepinfo swissprot:RLMA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RLMA_ECOLI pepnet swissprot:RLMA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RLMA_ECOLI pepstats swissprot:RLMA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RLMA_ECOLI pepwheel swissprot:RLMA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RLMA_ECOLI pepwindow swissprot:RLMA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RLMA_ECOLI sigcleave swissprot:RLMA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RLMA_ECOLI ## Database ID URL or Descriptions # AltName INSA1_ECOLI IS1a # EcoGene EG40001 insA1 # FUNCTION INSA1_ECOLI Absolutely required for transposition of IS1. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IMP:EcoCyc. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 1.10.10.60 -; 1. # InterPro IPR003220 InsA_N_dom # InterPro IPR009057 Homeodomain-like # InterPro IPR024431 InsA_HTH_dom # Organism INSA1_ECOLI Escherichia coli (strain K12) # PIR B93826 IEECB9 # PIR JN0134 JN0134 # Pfam PF03811 Zn_Tnp_IS1 # Pfam PF12759 HTH_Tnp_IS1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSA1_ECOLI Insertion element IS1 1 protein InsA # RefSeq NP_414563 NC_000913.3 # RefSeq NP_416408 NC_000913.3 # RefSeq NP_417901 NC_000913.3 # RefSeq WP_000179213 NZ_LN832404.1 # RefSeq YP_001816554 NC_010558.1 # RefSeq YP_001816567 NC_010558.1 # RefSeq YP_002527490 NC_011964.1 # RefSeq YP_003937745 NC_014615.1 # RefSeq YP_004422909 NC_015472.1 # RefSeq YP_444026 NC_007675.1 # RefSeq YP_444042 NC_007675.1 # SIMILARITY Belongs to the IS1 elements InsA family. {ECO 0000305}. # eggNOG COG3677 LUCA BLAST swissprot:INSA1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSA1_ECOLI BioCyc EcoCyc:G6086-MONOMER http://biocyc.org/getid?id=EcoCyc:G6086-MONOMER DOI 10.1007/BF00271673 http://dx.doi.org/10.1007/BF00271673 DOI 10.1016/0378-1119(91)90096-T http://dx.doi.org/10.1016/0378-1119(91)90096-T DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01729 http://www.ebi.ac.uk/ena/data/view/J01729 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X52534 http://www.ebi.ac.uk/ena/data/view/X52534 EchoBASE EB4701 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4701 EcoGene EG40001 http://www.ecogene.org/geneInfo.php?eg_id=EG40001 EnsemblBacteria AAC73133 http://www.ensemblgenomes.org/id/AAC73133 EnsemblBacteria AAC73133 http://www.ensemblgenomes.org/id/AAC73133 EnsemblBacteria BAE76034 http://www.ensemblgenomes.org/id/BAE76034 EnsemblBacteria BAE76034 http://www.ensemblgenomes.org/id/BAE76034 EnsemblBacteria BAE76034 http://www.ensemblgenomes.org/id/BAE76034 EnsemblBacteria b0022 http://www.ensemblgenomes.org/id/b0022 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 GeneID 10549031 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10549031 GeneID 24901758 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24901758 GeneID 3853367 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3853367 GeneID 3853482 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3853482 GeneID 6276006 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6276006 GeneID 6276014 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6276014 GeneID 7324512 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7324512 GeneID 945800 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945800 GeneID 947950 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947950 GeneID 948449 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948449 GeneID 9846072 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9846072 InParanoid P0CF07 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CF07 InterPro IPR003220 http://www.ebi.ac.uk/interpro/entry/IPR003220 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR024431 http://www.ebi.ac.uk/interpro/entry/IPR024431 KEGG_Gene ecj:JW0021 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0021 KEGG_Gene eco:b0022 http://www.genome.jp/dbget-bin/www_bget?eco:b0022 KEGG_Gene eco:b1894 http://www.genome.jp/dbget-bin/www_bget?eco:b1894 KEGG_Gene eco:b3444 http://www.genome.jp/dbget-bin/www_bget?eco:b3444 PSORT swissprot:INSA1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSA1_ECOLI PSORT-B swissprot:INSA1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSA1_ECOLI PSORT2 swissprot:INSA1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSA1_ECOLI Pfam PF03811 http://pfam.xfam.org/family/PF03811 Pfam PF12759 http://pfam.xfam.org/family/PF12759 Phobius swissprot:INSA1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSA1_ECOLI PhylomeDB P0CF07 http://phylomedb.org/?seqid=P0CF07 ProteinModelPortal P0CF07 http://www.proteinmodelportal.org/query/uniprot/P0CF07 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1849492 http://www.ncbi.nlm.nih.gov/pubmed/1849492 PubMed 375010 http://www.ncbi.nlm.nih.gov/pubmed/375010 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414563 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414563 RefSeq NP_416408 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416408 RefSeq NP_417901 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417901 RefSeq WP_000179213 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000179213 RefSeq YP_001816554 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001816554 RefSeq YP_001816567 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001816567 RefSeq YP_002527490 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_002527490 RefSeq YP_003937745 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_003937745 RefSeq YP_004422909 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_004422909 RefSeq YP_444026 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_444026 RefSeq YP_444042 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_444042 STRING 511145.b3444 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3444&targetmode=cogs UniProtKB INSA1_ECOLI http://www.uniprot.org/uniprot/INSA1_ECOLI UniProtKB-AC P0CF07 http://www.uniprot.org/uniprot/P0CF07 charge swissprot:INSA1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSA1_ECOLI eggNOG COG3677 http://eggnogapi.embl.de/nog_data/html/tree/COG3677 epestfind swissprot:INSA1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSA1_ECOLI garnier swissprot:INSA1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSA1_ECOLI helixturnhelix swissprot:INSA1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSA1_ECOLI hmoment swissprot:INSA1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSA1_ECOLI iep swissprot:INSA1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSA1_ECOLI inforesidue swissprot:INSA1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSA1_ECOLI octanol swissprot:INSA1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSA1_ECOLI pepcoil swissprot:INSA1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSA1_ECOLI pepdigest swissprot:INSA1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSA1_ECOLI pepinfo swissprot:INSA1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSA1_ECOLI pepnet swissprot:INSA1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSA1_ECOLI pepstats swissprot:INSA1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSA1_ECOLI pepwheel swissprot:INSA1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSA1_ECOLI pepwindow swissprot:INSA1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSA1_ECOLI sigcleave swissprot:INSA1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSA1_ECOLI ## Database ID URL or Descriptions # BioGrid 4260671 113 # DISRUPTION PHENOTYPE Cells are not affected in cellular iron content and sensitivity to oxidants. {ECO:0000269|PubMed 10452520}. # EcoGene EG11653 cyaY # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008198 ferrous iron binding; IDA:EcoCyc. # GO_function GO:0008199 ferric iron binding; IDA:EcoCyc. # GO_process GO:0016226 iron-sulfur cluster assembly; IDA:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.30.920.10 -; 1. # HAMAP MF_00142 CyaY # IntAct P27838 2 # InterPro IPR002908 Frataxin/CyaY # InterPro IPR020895 Frataxin_CS # Organism CYAY_ECOLI Escherichia coli (strain K12) # PANTHER PTHR16821 PTHR16821 # PATRIC 32123113 VBIEscCol129921_3922 # PDB 1EW4 X-ray; 1.40 A; A=1-106 # PDB 1SOY NMR; -; A=1-106 # PDB 2EFF X-ray; 1.80 A; A=1-106 # PDB 2P1X X-ray; 1.42 A; A=1-106 # PIR S30697 S30697 # PROSITE PS01344 FRATAXIN_1 # PROSITE PS50810 FRATAXIN_2 # Pfam PF01491 Frataxin_Cyay # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CYAY_ECOLI Protein CyaY # RefSeq NP_418251 NC_000913.3 # RefSeq WP_000999947 NZ_LN832404.1 # SIMILARITY Belongs to the frataxin family. {ECO 0000305}. # SMART SM01219 Frataxin_Cyay # SUPFAM SSF55387 SSF55387 # TCDB 9.B.21.2 the frataxin (frataxin) family # TIGRFAMs TIGR03421 FeS_CyaY # eggNOG COG1965 LUCA # eggNOG ENOG4105XQ6 Bacteria BLAST swissprot:CYAY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CYAY_ECOLI BioCyc ECOL316407:JW3779-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3779-MONOMER BioCyc EcoCyc:EG11653-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11653-MONOMER BioCyc MetaCyc:EG11653-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11653-MONOMER COG COG1965 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1965 DIP DIP-9356N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9356N DOI 10.1016/0300-9084(96)82192-4 http://dx.doi.org/10.1016/0300-9084(96)82192-4 DOI 10.1016/S0014-5793(99)00896-0 http://dx.doi.org/10.1016/S0014-5793(99)00896-0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.160270897 http://dx.doi.org/10.1073/pnas.160270897 DOI 10.1093/nar/12.24.9427 http://dx.doi.org/10.1093/nar/12.24.9427 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X66782 http://www.ebi.ac.uk/ena/data/view/X66782 EchoBASE EB1606 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1606 EcoGene EG11653 http://www.ecogene.org/geneInfo.php?eg_id=EG11653 EnsemblBacteria AAC76810 http://www.ensemblgenomes.org/id/AAC76810 EnsemblBacteria AAC76810 http://www.ensemblgenomes.org/id/AAC76810 EnsemblBacteria BAE77494 http://www.ensemblgenomes.org/id/BAE77494 EnsemblBacteria BAE77494 http://www.ensemblgenomes.org/id/BAE77494 EnsemblBacteria BAE77494 http://www.ensemblgenomes.org/id/BAE77494 EnsemblBacteria b3807 http://www.ensemblgenomes.org/id/b3807 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008198 GO_function GO:0008199 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008199 GO_process GO:0016226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016226 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.30.920.10 http://www.cathdb.info/version/latest/superfamily/3.30.920.10 GeneID 947754 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947754 HAMAP MF_00142 http://hamap.expasy.org/unirule/MF_00142 HOGENOM HOG000190728 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000190728&db=HOGENOM6 InParanoid P27838 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P27838 IntAct P27838 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P27838* InterPro IPR002908 http://www.ebi.ac.uk/interpro/entry/IPR002908 InterPro IPR020895 http://www.ebi.ac.uk/interpro/entry/IPR020895 KEGG_Gene ecj:JW3779 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3779 KEGG_Gene eco:b3807 http://www.genome.jp/dbget-bin/www_bget?eco:b3807 KEGG_Orthology KO:K06202 http://www.genome.jp/dbget-bin/www_bget?KO:K06202 OMA LHQIWVA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LHQIWVA PANTHER PTHR16821 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16821 PDB 1EW4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1EW4 PDB 1SOY http://www.ebi.ac.uk/pdbe-srv/view/entry/1SOY PDB 2EFF http://www.ebi.ac.uk/pdbe-srv/view/entry/2EFF PDB 2P1X http://www.ebi.ac.uk/pdbe-srv/view/entry/2P1X PDBsum 1EW4 http://www.ebi.ac.uk/pdbsum/1EW4 PDBsum 1SOY http://www.ebi.ac.uk/pdbsum/1SOY PDBsum 2EFF http://www.ebi.ac.uk/pdbsum/2EFF PDBsum 2P1X http://www.ebi.ac.uk/pdbsum/2P1X PROSITE PS01344 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01344 PROSITE PS50810 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50810 PSORT swissprot:CYAY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CYAY_ECOLI PSORT-B swissprot:CYAY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CYAY_ECOLI PSORT2 swissprot:CYAY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CYAY_ECOLI Pfam PF01491 http://pfam.xfam.org/family/PF01491 Phobius swissprot:CYAY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CYAY_ECOLI PhylomeDB P27838 http://phylomedb.org/?seqid=P27838 ProteinModelPortal P27838 http://www.proteinmodelportal.org/query/uniprot/P27838 PubMed 10452520 http://www.ncbi.nlm.nih.gov/pubmed/10452520 PubMed 10908679 http://www.ncbi.nlm.nih.gov/pubmed/10908679 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6393056 http://www.ncbi.nlm.nih.gov/pubmed/6393056 PubMed 8418825 http://www.ncbi.nlm.nih.gov/pubmed/8418825 PubMed 8874804 http://www.ncbi.nlm.nih.gov/pubmed/8874804 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418251 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418251 RefSeq WP_000999947 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000999947 SMART SM01219 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01219 SMR P27838 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P27838 STRING 511145.b3807 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3807&targetmode=cogs STRING COG1965 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1965&targetmode=cogs SUPFAM SSF55387 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55387 TCDB 9.B.21.2 http://www.tcdb.org/search/result.php?tc=9.B.21.2 TIGRFAMs TIGR03421 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03421 UniProtKB CYAY_ECOLI http://www.uniprot.org/uniprot/CYAY_ECOLI UniProtKB-AC P27838 http://www.uniprot.org/uniprot/P27838 charge swissprot:CYAY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CYAY_ECOLI eggNOG COG1965 http://eggnogapi.embl.de/nog_data/html/tree/COG1965 eggNOG ENOG4105XQ6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105XQ6 epestfind swissprot:CYAY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CYAY_ECOLI garnier swissprot:CYAY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CYAY_ECOLI helixturnhelix swissprot:CYAY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CYAY_ECOLI hmoment swissprot:CYAY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CYAY_ECOLI iep swissprot:CYAY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CYAY_ECOLI inforesidue swissprot:CYAY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CYAY_ECOLI octanol swissprot:CYAY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CYAY_ECOLI pepcoil swissprot:CYAY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CYAY_ECOLI pepdigest swissprot:CYAY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CYAY_ECOLI pepinfo swissprot:CYAY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CYAY_ECOLI pepnet swissprot:CYAY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CYAY_ECOLI pepstats swissprot:CYAY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CYAY_ECOLI pepwheel swissprot:CYAY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CYAY_ECOLI pepwindow swissprot:CYAY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CYAY_ECOLI sigcleave swissprot:CYAY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CYAY_ECOLI ## Database ID URL or Descriptions # EcoGene EG14479 ynbG # INDUCTION In stationary phase (at protein level). {ECO:0000269|PubMed 19121005}. # Organism YNBG_ECOLI Escherichia coli (strain K12) # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNBG_ECOLI Uncharacterized protein YnbG # RefSeq YP_002791240 NC_000913.3 BLAST swissprot:YNBG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNBG_ECOLI BioCyc EcoCyc:MONOMER0-2873 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2873 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2008.06495.x http://dx.doi.org/10.1111/j.1365-2958.2008.06495.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14479 http://www.ecogene.org/geneInfo.php?eg_id=EG14479 EnsemblBacteria ACO59992 http://www.ensemblgenomes.org/id/ACO59992 EnsemblBacteria ACO59992 http://www.ensemblgenomes.org/id/ACO59992 EnsemblBacteria b4674 http://www.ensemblgenomes.org/id/b4674 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 7751614 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7751614 KEGG_Gene eco:b4674 http://www.genome.jp/dbget-bin/www_bget?eco:b4674 PSORT swissprot:YNBG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNBG_ECOLI PSORT-B swissprot:YNBG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNBG_ECOLI PSORT2 swissprot:YNBG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNBG_ECOLI Phobius swissprot:YNBG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNBG_ECOLI PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19121005 http://www.ncbi.nlm.nih.gov/pubmed/19121005 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq YP_002791240 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_002791240 STRING 511145.b4674 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4674&targetmode=cogs UniProtKB YNBG_ECOLI http://www.uniprot.org/uniprot/YNBG_ECOLI UniProtKB-AC C1P600 http://www.uniprot.org/uniprot/C1P600 charge swissprot:YNBG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNBG_ECOLI epestfind swissprot:YNBG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNBG_ECOLI garnier swissprot:YNBG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNBG_ECOLI helixturnhelix swissprot:YNBG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNBG_ECOLI hmoment swissprot:YNBG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNBG_ECOLI iep swissprot:YNBG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNBG_ECOLI inforesidue swissprot:YNBG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNBG_ECOLI octanol swissprot:YNBG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNBG_ECOLI pepcoil swissprot:YNBG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNBG_ECOLI pepdigest swissprot:YNBG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNBG_ECOLI pepinfo swissprot:YNBG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNBG_ECOLI pepnet swissprot:YNBG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNBG_ECOLI pepstats swissprot:YNBG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNBG_ECOLI pepwheel swissprot:YNBG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNBG_ECOLI pepwindow swissprot:YNBG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNBG_ECOLI sigcleave swissprot:YNBG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNBG_ECOLI ## Database ID URL or Descriptions # AltName DEOC_ECOLI 2-deoxy-D-ribose 5-phosphate aldolase # AltName DEOC_ECOLI Phosphodeoxyriboaldolase # BRENDA 4.1.2 2026 # BioGrid 4263350 9 # CATALYTIC ACTIVITY DEOC_ECOLI 2-deoxy-D-ribose 5-phosphate = D- glyceraldehyde 3-phosphate + acetaldehyde. # CDD cd00959 DeoC # EcoGene EG10221 deoC # FUNCTION DEOC_ECOLI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0004139 deoxyribose-phosphate aldolase activity; IDA:EcoCyc. # GO_function GO:0016829 lyase activity; IDA:EcoliWiki. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0009264 deoxyribonucleotide catabolic process; IMP:EcoliWiki. # GO_process GO:0015949 nucleobase-containing small molecule interconversion; IMP:EcoliWiki. # GO_process GO:0016052 carbohydrate catabolic process; IDA:EcoliWiki. # GO_process GO:0046386 deoxyribose phosphate catabolic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.70 -; 1. # HAMAP MF_00592 DeoC_type2 # IntAct P0A6L0 8 # InterPro IPR002915 DeoC/FbaB/lacD_aldolase # InterPro IPR011343 DeoC # InterPro IPR013785 Aldolase_TIM # InterPro IPR023649 DeoC_typeII # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00030 Pentose phosphate pathway # Organism DEOC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10889 PTHR10889 # PATHWAY Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2- deoxy-alpha-D-ribose 1-phosphate step 2/2. # PATRIC 32124378 VBIEscCol129921_4529 # PDB 1JCJ X-ray; 1.10 A; A/B=1-259 # PDB 1JCL X-ray; 1.05 A; A/B=1-259 # PDB 1KTN X-ray; 1.40 A; A/B=1-250 # PDB 1P1X X-ray; 0.99 A; A/B=1-259 # PDB 5EKY X-ray; 1.10 A; A=1-259 # PDB 5EL1 X-ray; 1.25 A; A=1-259 # PDB 5EMU X-ray; 1.50 A; A=1-259 # PIR A01102 ADECD # PIRSF PIRSF001357 DeoC # Pfam PF01791 DeoC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DEOC_ECOLI Deoxyribose-phosphate aldolase # RefSeq NP_418798 NC_000913.3 # RefSeq WP_001298497 NZ_LN832404.1 # SIMILARITY Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily. {ECO 0000305}. # SMART SM01133 DeoC # SUBCELLULAR LOCATION DEOC_ECOLI Cytoplasm. # SUBUNIT DEOC_ECOLI Monomer and homodimer. # TIGRFAMs TIGR00126 deoC # UniPathway UPA00002 UER00468 # eggNOG COG0274 LUCA # eggNOG ENOG4105FCI Bacteria BLAST swissprot:DEOC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DEOC_ECOLI BioCyc ECOL316407:JW4344-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4344-MONOMER BioCyc EcoCyc:DEOXYRIBOSE-P-ALD-MONOMER http://biocyc.org/getid?id=EcoCyc:DEOXYRIBOSE-P-ALD-MONOMER BioCyc MetaCyc:DEOXYRIBOSE-P-ALD-MONOMER http://biocyc.org/getid?id=MetaCyc:DEOXYRIBOSE-P-ALD-MONOMER COG COG0274 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0274 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1111/j.1432-1033.1982.tb06719.x http://dx.doi.org/10.1111/j.1432-1033.1982.tb06719.x DOI 10.1126/science.1063601 http://dx.doi.org/10.1126/science.1063601 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.1.2.4 http://www.genome.jp/dbget-bin/www_bget?EC:4.1.2.4 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X03224 http://www.ebi.ac.uk/ena/data/view/X03224 ENZYME 4.1.2.4 http://enzyme.expasy.org/EC/4.1.2.4 EchoBASE EB0217 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0217 EcoGene EG10221 http://www.ecogene.org/geneInfo.php?eg_id=EG10221 EnsemblBacteria AAC77334 http://www.ensemblgenomes.org/id/AAC77334 EnsemblBacteria AAC77334 http://www.ensemblgenomes.org/id/AAC77334 EnsemblBacteria BAE78370 http://www.ensemblgenomes.org/id/BAE78370 EnsemblBacteria BAE78370 http://www.ensemblgenomes.org/id/BAE78370 EnsemblBacteria BAE78370 http://www.ensemblgenomes.org/id/BAE78370 EnsemblBacteria b4381 http://www.ensemblgenomes.org/id/b4381 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0004139 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004139 GO_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0009264 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009264 GO_process GO:0015949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015949 GO_process GO:0016052 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016052 GO_process GO:0046386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046386 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 948902 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948902 HAMAP MF_00592 http://hamap.expasy.org/unirule/MF_00592 HOGENOM HOG000241644 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000241644&db=HOGENOM6 InParanoid P0A6L0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6L0 IntAct P0A6L0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6L0* IntEnz 4.1.2.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.2.4 InterPro IPR002915 http://www.ebi.ac.uk/interpro/entry/IPR002915 InterPro IPR011343 http://www.ebi.ac.uk/interpro/entry/IPR011343 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR023649 http://www.ebi.ac.uk/interpro/entry/IPR023649 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4344 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4344 KEGG_Gene eco:b4381 http://www.genome.jp/dbget-bin/www_bget?eco:b4381 KEGG_Orthology KO:K01619 http://www.genome.jp/dbget-bin/www_bget?KO:K01619 KEGG_Pathway ko00030 http://www.genome.jp/kegg-bin/show_pathway?ko00030 KEGG_Reaction rn:R01066 http://www.genome.jp/dbget-bin/www_bget?rn:R01066 OMA KIATVTN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KIATVTN PANTHER PTHR10889 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10889 PDB 1JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1JCJ PDB 1JCL http://www.ebi.ac.uk/pdbe-srv/view/entry/1JCL PDB 1KTN http://www.ebi.ac.uk/pdbe-srv/view/entry/1KTN PDB 1P1X http://www.ebi.ac.uk/pdbe-srv/view/entry/1P1X PDB 5EKY http://www.ebi.ac.uk/pdbe-srv/view/entry/5EKY PDB 5EL1 http://www.ebi.ac.uk/pdbe-srv/view/entry/5EL1 PDB 5EMU http://www.ebi.ac.uk/pdbe-srv/view/entry/5EMU PDBsum 1JCJ http://www.ebi.ac.uk/pdbsum/1JCJ PDBsum 1JCL http://www.ebi.ac.uk/pdbsum/1JCL PDBsum 1KTN http://www.ebi.ac.uk/pdbsum/1KTN PDBsum 1P1X http://www.ebi.ac.uk/pdbsum/1P1X PDBsum 5EKY http://www.ebi.ac.uk/pdbsum/5EKY PDBsum 5EL1 http://www.ebi.ac.uk/pdbsum/5EL1 PDBsum 5EMU http://www.ebi.ac.uk/pdbsum/5EMU PSORT swissprot:DEOC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DEOC_ECOLI PSORT-B swissprot:DEOC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DEOC_ECOLI PSORT2 swissprot:DEOC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DEOC_ECOLI Pfam PF01791 http://pfam.xfam.org/family/PF01791 Phobius swissprot:DEOC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DEOC_ECOLI PhylomeDB P0A6L0 http://phylomedb.org/?seqid=P0A6L0 ProteinModelPortal P0A6L0 http://www.proteinmodelportal.org/query/uniprot/P0A6L0 PubMed 11598300 http://www.ncbi.nlm.nih.gov/pubmed/11598300 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 6749498 http://www.ncbi.nlm.nih.gov/pubmed/6749498 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418798 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418798 RefSeq WP_001298497 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001298497 SMART SM01133 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01133 SMR P0A6L0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6L0 STRING 511145.b4381 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4381&targetmode=cogs STRING COG0274 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0274&targetmode=cogs SWISS-2DPAGE P0A6L0 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A6L0 TIGRFAMs TIGR00126 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00126 UniProtKB DEOC_ECOLI http://www.uniprot.org/uniprot/DEOC_ECOLI UniProtKB-AC P0A6L0 http://www.uniprot.org/uniprot/P0A6L0 charge swissprot:DEOC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DEOC_ECOLI eggNOG COG0274 http://eggnogapi.embl.de/nog_data/html/tree/COG0274 eggNOG ENOG4105FCI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FCI epestfind swissprot:DEOC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DEOC_ECOLI garnier swissprot:DEOC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DEOC_ECOLI helixturnhelix swissprot:DEOC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DEOC_ECOLI hmoment swissprot:DEOC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DEOC_ECOLI iep swissprot:DEOC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DEOC_ECOLI inforesidue swissprot:DEOC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DEOC_ECOLI octanol swissprot:DEOC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DEOC_ECOLI pepcoil swissprot:DEOC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DEOC_ECOLI pepdigest swissprot:DEOC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DEOC_ECOLI pepinfo swissprot:DEOC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DEOC_ECOLI pepnet swissprot:DEOC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DEOC_ECOLI pepstats swissprot:DEOC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DEOC_ECOLI pepwheel swissprot:DEOC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DEOC_ECOLI pepwindow swissprot:DEOC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DEOC_ECOLI sigcleave swissprot:DEOC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DEOC_ECOLI ## Database ID URL or Descriptions # EcoGene EG40004 insD1 # FUNCTION INSD1_ECOLI Involved in the transposition of the insertion sequence IS2. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006310 DNA recombination; IEA:UniProtKB-KW. # GO_process GO:0015074 DNA integration; IEA:InterPro. # GO_process GO:0032196 transposition; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 3.30.420.10 -; 1. # InterPro IPR001584 Integrase_cat-core # InterPro IPR012337 RNaseH-like_dom # InterPro IPR025948 HTH-like_dom # Organism INSD1_ECOLI Escherichia coli (strain K12) # PIR A64764 C65092 # PROSITE PS50994 INTEGRASE # Pfam PF00665 rve # Pfam PF13276 HTH_21 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSD1_ECOLI Transposase InsD for insertion element IS2A # RefSeq NP_061399 NC_002483.1 # RefSeq NP_414895 NC_000913.3 # RefSeq NP_415920 NC_000913.3 # RefSeq NP_416500 NC_000913.3 # RefSeq NP_417337 NC_000913.3 # RefSeq NP_417517 NC_000913.3 # RefSeq NP_418693 NC_000913.3 # RefSeq WP_000376502 NZ_LN832404.1 # RefSeq YP_424823 NC_007635.1 # SIMILARITY Contains 1 integrase catalytic domain. {ECO:0000255|PROSITE-ProRule PRU00457}. # SUPFAM SSF53098 SSF53098 # eggNOG ENOG4108MVM Bacteria # eggNOG ENOG410Z4Y8 LUCA BLAST swissprot:INSD1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSD1_ECOLI BioCyc EcoCyc:G7480-MONOMER http://biocyc.org/getid?id=EcoCyc:G7480-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB4752 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4752 EcoGene EG40004 http://www.ecogene.org/geneInfo.php?eg_id=EG40004 EnsemblBacteria AAC73464 http://www.ensemblgenomes.org/id/AAC73464 EnsemblBacteria AAC73464 http://www.ensemblgenomes.org/id/AAC73464 EnsemblBacteria BAE76142 http://www.ensemblgenomes.org/id/BAE76142 EnsemblBacteria BAE76142 http://www.ensemblgenomes.org/id/BAE76142 EnsemblBacteria BAE76142 http://www.ensemblgenomes.org/id/BAE76142 EnsemblBacteria b0361 http://www.ensemblgenomes.org/id/b0361 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0015074 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015074 GO_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 3.30.420.10 http://www.cathdb.info/version/latest/superfamily/3.30.420.10 GeneID 1263540 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263540 GeneID 3829341 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3829341 GeneID 945203 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945203 GeneID 945952 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945952 GeneID 946403 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946403 GeneID 947346 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947346 GeneID 947517 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947517 GeneID 948779 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948779 InParanoid P0CF53 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CF53 InterPro IPR001584 http://www.ebi.ac.uk/interpro/entry/IPR001584 InterPro IPR012337 http://www.ebi.ac.uk/interpro/entry/IPR012337 InterPro IPR025948 http://www.ebi.ac.uk/interpro/entry/IPR025948 KEGG_Gene ecj:JW0352 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0352 KEGG_Gene eco:b0361 http://www.genome.jp/dbget-bin/www_bget?eco:b0361 KEGG_Gene eco:b1402 http://www.genome.jp/dbget-bin/www_bget?eco:b1402 KEGG_Gene eco:b1996 http://www.genome.jp/dbget-bin/www_bget?eco:b1996 KEGG_Gene eco:b2860 http://www.genome.jp/dbget-bin/www_bget?eco:b2860 KEGG_Gene eco:b3045 http://www.genome.jp/dbget-bin/www_bget?eco:b3045 KEGG_Gene eco:b4273 http://www.genome.jp/dbget-bin/www_bget?eco:b4273 OMA ARSNQRW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ARSNQRW PROSITE PS50994 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50994 PSORT swissprot:INSD1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSD1_ECOLI PSORT-B swissprot:INSD1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSD1_ECOLI PSORT2 swissprot:INSD1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSD1_ECOLI Pfam PF00665 http://pfam.xfam.org/family/PF00665 Pfam PF13276 http://pfam.xfam.org/family/PF13276 Phobius swissprot:INSD1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSD1_ECOLI PhylomeDB P0CF53 http://phylomedb.org/?seqid=P0CF53 ProteinModelPortal P0CF53 http://www.proteinmodelportal.org/query/uniprot/P0CF53 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_061399 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061399 RefSeq NP_414895 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414895 RefSeq NP_415920 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415920 RefSeq NP_416500 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416500 RefSeq NP_417337 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417337 RefSeq NP_417517 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417517 RefSeq NP_418693 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418693 RefSeq WP_000376502 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000376502 RefSeq YP_424823 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_424823 SMR P0CF53 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0CF53 STRING 511145.b4273 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4273&targetmode=cogs SUPFAM SSF53098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098 UniProtKB INSD1_ECOLI http://www.uniprot.org/uniprot/INSD1_ECOLI UniProtKB-AC P0CF53 http://www.uniprot.org/uniprot/P0CF53 charge swissprot:INSD1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSD1_ECOLI eggNOG ENOG4108MVM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MVM eggNOG ENOG410Z4Y8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Z4Y8 epestfind swissprot:INSD1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSD1_ECOLI garnier swissprot:INSD1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSD1_ECOLI helixturnhelix swissprot:INSD1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSD1_ECOLI hmoment swissprot:INSD1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSD1_ECOLI iep swissprot:INSD1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSD1_ECOLI inforesidue swissprot:INSD1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSD1_ECOLI octanol swissprot:INSD1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSD1_ECOLI pepcoil swissprot:INSD1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSD1_ECOLI pepdigest swissprot:INSD1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSD1_ECOLI pepinfo swissprot:INSD1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSD1_ECOLI pepnet swissprot:INSD1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSD1_ECOLI pepstats swissprot:INSD1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSD1_ECOLI pepwheel swissprot:INSD1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSD1_ECOLI pepwindow swissprot:INSD1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSD1_ECOLI sigcleave swissprot:INSD1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSD1_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES NUDJ_ECOLI Kinetic parameters KM=0.64 mM for GDP {ECO 0000269|PubMed 16766526}; Vmax=12 umol/min/mg enzyme with GDP as substrate {ECO 0000269|PubMed 16766526}; pH dependence Optimum pH is about 8.5. {ECO 0000269|PubMed 16766526}; # BioGrid 4263128 44 # CDD cd03675 Nudix_Hydrolase_2 # COFACTOR NUDJ_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 16766526}; # EcoGene EG13446 nudJ # FUNCTION NUDJ_ECOLI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P), and hydrolysis of thiamine pyrophosphate (TPP) to thiamine monophosphate (TMP). Can hydrolyze other substrates such as MeO-HMP-PP, CF(3)-HMP-PP and MeO-TPP. Is also a non-specific nucleoside tri- and diphosphatase that releases inorganic orthophosphate. {ECO 0000269|PubMed 15292217, ECO 0000269|PubMed 16766526}. # GO_function GO:0004787 thiamine-pyrophosphatase activity; IDA:EcoCyc. # GO_function GO:0017110 nucleoside-diphosphatase activity; IDA:EcoCyc. # GO_function GO:0017111 nucleoside-triphosphatase activity; IDA:EcoCyc. # GOslim_function GO:0003674 molecular_function # Gene3D 3.90.79.10 -; 1. # IntAct P0AEI6 5 # InterPro IPR000086 NUDIX_hydrolase_dom # InterPro IPR015797 NUDIX_hydrolase_dom-like # InterPro IPR020084 NUDIX_hydrolase_CS # InterPro IPR020476 Nudix_hydrolase # InterPro IPR033713 NudJ # KEGG_Brite ko01000 Enzymes # Organism NUDJ_ECOLI Escherichia coli (strain K12) # PATRIC 32117517 VBIEscCol129921_1181 # PIR C64858 C64858 # PRINTS PR00502 NUDIXFAMILY # PROSITE PS00893 NUDIX_BOX # PROSITE PS51462 NUDIX # Pfam PF00293 NUDIX # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NUDJ_ECOLI Phosphatase NudJ # RefSeq NP_415652 NC_000913.3 # RefSeq WP_000476093 NZ_LN832404.1 # SIMILARITY Belongs to the Nudix hydrolase family. NudJ subfamily. {ECO 0000305}. # SIMILARITY Contains 1 nudix hydrolase domain. {ECO:0000255|PROSITE-ProRule PRU00794}. # SUBUNIT Monomer. {ECO:0000269|PubMed 16766526}. # SUPFAM SSF55811 SSF55811 # eggNOG COG0494 LUCA # eggNOG ENOG4105KB7 Bacteria BLAST swissprot:NUDJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NUDJ_ECOLI BioCyc ECOL316407:JW1120-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1120-MONOMER BioCyc EcoCyc:G6580-MONOMER http://biocyc.org/getid?id=EcoCyc:G6580-MONOMER BioCyc MetaCyc:G6580-MONOMER http://biocyc.org/getid?id=MetaCyc:G6580-MONOMER COG COG0494 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0494 DIP DIP-35908N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35908N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M404284200 http://dx.doi.org/10.1074/jbc.M404284200 DOI 10.1074/jbc.M603407200 http://dx.doi.org/10.1074/jbc.M603407200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.1.- http://www.genome.jp/dbget-bin/www_bget?EC:3.6.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.6.1.- http://enzyme.expasy.org/EC/3.6.1.- EchoBASE EB3220 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3220 EcoGene EG13446 http://www.ecogene.org/geneInfo.php?eg_id=EG13446 EnsemblBacteria AAC74218 http://www.ensemblgenomes.org/id/AAC74218 EnsemblBacteria AAC74218 http://www.ensemblgenomes.org/id/AAC74218 EnsemblBacteria BAA35956 http://www.ensemblgenomes.org/id/BAA35956 EnsemblBacteria BAA35956 http://www.ensemblgenomes.org/id/BAA35956 EnsemblBacteria BAA35956 http://www.ensemblgenomes.org/id/BAA35956 EnsemblBacteria b1134 http://www.ensemblgenomes.org/id/b1134 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004787 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004787 GO_function GO:0017110 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017110 GO_function GO:0017111 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017111 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 Gene3D 3.90.79.10 http://www.cathdb.info/version/latest/superfamily/3.90.79.10 GeneID 945689 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945689 HOGENOM HOG000256353 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000256353&db=HOGENOM6 InParanoid P0AEI6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEI6 IntAct P0AEI6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEI6* IntEnz 3.6.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.1 InterPro IPR000086 http://www.ebi.ac.uk/interpro/entry/IPR000086 InterPro IPR015797 http://www.ebi.ac.uk/interpro/entry/IPR015797 InterPro IPR020084 http://www.ebi.ac.uk/interpro/entry/IPR020084 InterPro IPR020476 http://www.ebi.ac.uk/interpro/entry/IPR020476 InterPro IPR033713 http://www.ebi.ac.uk/interpro/entry/IPR033713 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1120 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1120 KEGG_Gene eco:b1134 http://www.genome.jp/dbget-bin/www_bget?eco:b1134 KEGG_Orthology KO:K12152 http://www.genome.jp/dbget-bin/www_bget?KO:K12152 OMA RWKPNVT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RWKPNVT PRINTS PR00502 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00502 PROSITE PS00893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00893 PROSITE PS51462 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51462 PSORT swissprot:NUDJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NUDJ_ECOLI PSORT-B swissprot:NUDJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NUDJ_ECOLI PSORT2 swissprot:NUDJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NUDJ_ECOLI Pfam PF00293 http://pfam.xfam.org/family/PF00293 Phobius swissprot:NUDJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NUDJ_ECOLI PhylomeDB P0AEI6 http://phylomedb.org/?seqid=P0AEI6 ProteinModelPortal P0AEI6 http://www.proteinmodelportal.org/query/uniprot/P0AEI6 PubMed 15292217 http://www.ncbi.nlm.nih.gov/pubmed/15292217 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16766526 http://www.ncbi.nlm.nih.gov/pubmed/16766526 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415652 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415652 RefSeq WP_000476093 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000476093 SMR P0AEI6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEI6 STRING 511145.b1134 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1134&targetmode=cogs STRING COG0494 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0494&targetmode=cogs SUPFAM SSF55811 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55811 UniProtKB NUDJ_ECOLI http://www.uniprot.org/uniprot/NUDJ_ECOLI UniProtKB-AC P0AEI6 http://www.uniprot.org/uniprot/P0AEI6 charge swissprot:NUDJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NUDJ_ECOLI eggNOG COG0494 http://eggnogapi.embl.de/nog_data/html/tree/COG0494 eggNOG ENOG4105KB7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KB7 epestfind swissprot:NUDJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NUDJ_ECOLI garnier swissprot:NUDJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NUDJ_ECOLI helixturnhelix swissprot:NUDJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NUDJ_ECOLI hmoment swissprot:NUDJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NUDJ_ECOLI iep swissprot:NUDJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NUDJ_ECOLI inforesidue swissprot:NUDJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NUDJ_ECOLI octanol swissprot:NUDJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NUDJ_ECOLI pepcoil swissprot:NUDJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NUDJ_ECOLI pepdigest swissprot:NUDJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NUDJ_ECOLI pepinfo swissprot:NUDJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NUDJ_ECOLI pepnet swissprot:NUDJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NUDJ_ECOLI pepstats swissprot:NUDJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NUDJ_ECOLI pepwheel swissprot:NUDJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NUDJ_ECOLI pepwindow swissprot:NUDJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NUDJ_ECOLI sigcleave swissprot:NUDJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NUDJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4259566 9 # EcoGene EG13373 ynaE # INDUCTION By cold shock. {ECO:0000269|PubMed 14527658}. # IntAct P76073 26 # Organism YNAE_ECOLI Escherichia coli (strain K12) # PATRIC 32118032 VBIEscCol129921_1436 # PIR B64888 B64888 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNAE_ECOLI Uncharacterized protein YnaE # RefSeq NP_415893 NC_000913.3 # RefSeq WP_000836770 NZ_CP014272.1 # SEQUENCE CAUTION Sequence=BAE76419.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY To E.coli YdfK. {ECO 0000305}. # eggNOG ENOG4105W3V Bacteria # eggNOG ENOG411246H LUCA BLAST swissprot:YNAE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNAE_ECOLI BioCyc ECOL316407:JW1369-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1369-MONOMER BioCyc EcoCyc:G6698-MONOMER http://biocyc.org/getid?id=EcoCyc:G6698-MONOMER DOI 10.1016/S0923-2508(03)00167-0 http://dx.doi.org/10.1016/S0923-2508(03)00167-0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00398-11 http://dx.doi.org/10.1128/JB.00398-11 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3155 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3155 EcoGene EG13373 http://www.ecogene.org/geneInfo.php?eg_id=EG13373 EnsemblBacteria AAC74457 http://www.ensemblgenomes.org/id/AAC74457 EnsemblBacteria AAC74457 http://www.ensemblgenomes.org/id/AAC74457 EnsemblBacteria BAE76419 http://www.ensemblgenomes.org/id/BAE76419 EnsemblBacteria BAE76419 http://www.ensemblgenomes.org/id/BAE76419 EnsemblBacteria BAE76419 http://www.ensemblgenomes.org/id/BAE76419 EnsemblBacteria b1375 http://www.ensemblgenomes.org/id/b1375 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946078 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946078 HOGENOM HOG000127820 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000127820&db=HOGENOM6 IntAct P76073 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76073* KEGG_Gene ecj:JW1369 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1369 KEGG_Gene eco:b1375 http://www.genome.jp/dbget-bin/www_bget?eco:b1375 PSORT swissprot:YNAE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNAE_ECOLI PSORT-B swissprot:YNAE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNAE_ECOLI PSORT2 swissprot:YNAE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNAE_ECOLI Phobius swissprot:YNAE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNAE_ECOLI ProteinModelPortal P76073 http://www.proteinmodelportal.org/query/uniprot/P76073 PubMed 14527658 http://www.ncbi.nlm.nih.gov/pubmed/14527658 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21460078 http://www.ncbi.nlm.nih.gov/pubmed/21460078 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415893 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415893 RefSeq WP_000836770 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000836770 STRING 511145.b1375 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1375&targetmode=cogs UniProtKB YNAE_ECOLI http://www.uniprot.org/uniprot/YNAE_ECOLI UniProtKB-AC P76073 http://www.uniprot.org/uniprot/P76073 charge swissprot:YNAE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNAE_ECOLI eggNOG ENOG4105W3V http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105W3V eggNOG ENOG411246H http://eggnogapi.embl.de/nog_data/html/tree/ENOG411246H epestfind swissprot:YNAE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNAE_ECOLI garnier swissprot:YNAE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNAE_ECOLI helixturnhelix swissprot:YNAE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNAE_ECOLI hmoment swissprot:YNAE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNAE_ECOLI iep swissprot:YNAE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNAE_ECOLI inforesidue swissprot:YNAE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNAE_ECOLI octanol swissprot:YNAE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNAE_ECOLI pepcoil swissprot:YNAE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNAE_ECOLI pepdigest swissprot:YNAE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNAE_ECOLI pepinfo swissprot:YNAE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNAE_ECOLI pepnet swissprot:YNAE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNAE_ECOLI pepstats swissprot:YNAE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNAE_ECOLI pepwheel swissprot:YNAE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNAE_ECOLI pepwindow swissprot:YNAE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNAE_ECOLI sigcleave swissprot:YNAE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNAE_ECOLI ## Database ID URL or Descriptions # BioGrid 4260861 12 # EcoGene EG14146 yfdX # INDUCTION YFDX_ECOLI By EvgA. # IntAct P76520 2 # InterPro IPR021236 Uncharacterised_YfdX # Organism YFDX_ECOLI Escherichia coli (strain K12) # PATRIC 32120129 VBIEscCol129921_2473 # PIR D65011 D65011 # Pfam PF10938 YfdX # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFDX_ECOLI Protein YfdX # RefSeq NP_416876 NC_000913.3 # RefSeq WP_000825600 NZ_LN832404.1 # eggNOG ENOG4108V08 Bacteria # eggNOG ENOG4111IX2 LUCA BLAST swissprot:YFDX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFDX_ECOLI BioCyc ECOL316407:JW2372-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2372-MONOMER BioCyc EcoCyc:G7238-MONOMER http://biocyc.org/getid?id=EcoCyc:G7238-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.183.4.1455-1458.2001 http://dx.doi.org/10.1128/JB.183.4.1455-1458.2001 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3898 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3898 EcoGene EG14146 http://www.ecogene.org/geneInfo.php?eg_id=EG14146 EnsemblBacteria AAC75434 http://www.ensemblgenomes.org/id/AAC75434 EnsemblBacteria AAC75434 http://www.ensemblgenomes.org/id/AAC75434 EnsemblBacteria BAE76705 http://www.ensemblgenomes.org/id/BAE76705 EnsemblBacteria BAE76705 http://www.ensemblgenomes.org/id/BAE76705 EnsemblBacteria BAE76705 http://www.ensemblgenomes.org/id/BAE76705 EnsemblBacteria b2375 http://www.ensemblgenomes.org/id/b2375 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 949108 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949108 HOGENOM HOG000122901 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122901&db=HOGENOM6 IntAct P76520 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76520* InterPro IPR021236 http://www.ebi.ac.uk/interpro/entry/IPR021236 KEGG_Gene ecj:JW2372 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2372 KEGG_Gene eco:b2375 http://www.genome.jp/dbget-bin/www_bget?eco:b2375 OMA TETQYLM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TETQYLM PSORT swissprot:YFDX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFDX_ECOLI PSORT-B swissprot:YFDX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFDX_ECOLI PSORT2 swissprot:YFDX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFDX_ECOLI Pfam PF10938 http://pfam.xfam.org/family/PF10938 Phobius swissprot:YFDX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFDX_ECOLI ProteinModelPortal P76520 http://www.proteinmodelportal.org/query/uniprot/P76520 PubMed 11157960 http://www.ncbi.nlm.nih.gov/pubmed/11157960 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416876 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416876 RefSeq WP_000825600 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000825600 SMR P76520 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76520 STRING 511145.b2375 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2375&targetmode=cogs UniProtKB YFDX_ECOLI http://www.uniprot.org/uniprot/YFDX_ECOLI UniProtKB-AC P76520 http://www.uniprot.org/uniprot/P76520 charge swissprot:YFDX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFDX_ECOLI eggNOG ENOG4108V08 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108V08 eggNOG ENOG4111IX2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111IX2 epestfind swissprot:YFDX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFDX_ECOLI garnier swissprot:YFDX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFDX_ECOLI helixturnhelix swissprot:YFDX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFDX_ECOLI hmoment swissprot:YFDX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFDX_ECOLI iep swissprot:YFDX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFDX_ECOLI inforesidue swissprot:YFDX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFDX_ECOLI octanol swissprot:YFDX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFDX_ECOLI pepcoil swissprot:YFDX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFDX_ECOLI pepdigest swissprot:YFDX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFDX_ECOLI pepinfo swissprot:YFDX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFDX_ECOLI pepnet swissprot:YFDX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFDX_ECOLI pepstats swissprot:YFDX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFDX_ECOLI pepwheel swissprot:YFDX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFDX_ECOLI pepwindow swissprot:YFDX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFDX_ECOLI sigcleave swissprot:YFDX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFDX_ECOLI ## Database ID URL or Descriptions # BioGrid 4260972 3 # EcoGene EG12550 yjhH # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0047440 2-dehydro-3-deoxy-D-pentonate aldolase activity; IMP:EcoCyc. # GO_process GO:0046176 aldonic acid catabolic process; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.70 -; 1. # InterPro IPR002220 DapA-like # InterPro IPR013785 Aldolase_TIM # InterPro IPR020624 Schiff_base-form_aldolases_CS # InterPro IPR020625 Schiff_base-form_aldolases_AS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00300 Lysine biosynthesis # Organism YJHH_ECOLI Escherichia coli (strain K12) # PANTHER PTHR12128 PTHR12128 # PATRIC 32124182 VBIEscCol129921_4434 # PIR S56523 S56523 # PIRSF PIRSF001365 DHDPS # PRINTS PR00146 DHPICSNTHASE # PROSITE PS00665 DHDPS_1 # PROSITE PS00666 DHDPS_2 # Pfam PF00701 DHDPS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJHH_ECOLI Uncharacterized lyase YjhH # RefSeq NP_418718 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA97194.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the DapA family. {ECO 0000305}. # SMART SM01130 DHDPS # SUBCELLULAR LOCATION YJHH_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Homotetramer. {ECO 0000250}. # eggNOG COG0329 LUCA # eggNOG ENOG4105CDP Bacteria BLAST swissprot:YJHH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJHH_ECOLI BioCyc ECOL316407:JW5775-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5775-MONOMER BioCyc EcoCyc:G7911-MONOMER http://biocyc.org/getid?id=EcoCyc:G7911-MONOMER BioCyc MetaCyc:G7911-MONOMER http://biocyc.org/getid?id=MetaCyc:G7911-MONOMER COG COG0329 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0329 DIP DIP-12622N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12622N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:4.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 4.-.-.- http://enzyme.expasy.org/EC/4.-.-.- EchoBASE EB2438 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2438 EcoGene EG12550 http://www.ecogene.org/geneInfo.php?eg_id=EG12550 EnsemblBacteria AAC77254 http://www.ensemblgenomes.org/id/AAC77254 EnsemblBacteria AAC77254 http://www.ensemblgenomes.org/id/AAC77254 EnsemblBacteria BAE78289 http://www.ensemblgenomes.org/id/BAE78289 EnsemblBacteria BAE78289 http://www.ensemblgenomes.org/id/BAE78289 EnsemblBacteria BAE78289 http://www.ensemblgenomes.org/id/BAE78289 EnsemblBacteria b4298 http://www.ensemblgenomes.org/id/b4298 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0047440 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047440 GO_process GO:0046176 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046176 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 948825 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948825 HOGENOM HOG000173604 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000173604&db=HOGENOM6 InParanoid P39359 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39359 IntAct P39359 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39359* IntEnz 4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4 InterPro IPR002220 http://www.ebi.ac.uk/interpro/entry/IPR002220 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR020624 http://www.ebi.ac.uk/interpro/entry/IPR020624 InterPro IPR020625 http://www.ebi.ac.uk/interpro/entry/IPR020625 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5775 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5775 KEGG_Gene eco:b4298 http://www.genome.jp/dbget-bin/www_bget?eco:b4298 KEGG_Orthology KO:K01714 http://www.genome.jp/dbget-bin/www_bget?KO:K01714 KEGG_Pathway ko00300 http://www.genome.jp/kegg-bin/show_pathway?ko00300 KEGG_Reaction rn:R10147 http://www.genome.jp/dbget-bin/www_bget?rn:R10147 MINT MINT-1301013 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1301013 OMA HGIDMGP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HGIDMGP PANTHER PTHR12128 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12128 PRINTS PR00146 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00146 PROSITE PS00665 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00665 PROSITE PS00666 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00666 PSORT swissprot:YJHH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJHH_ECOLI PSORT-B swissprot:YJHH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJHH_ECOLI PSORT2 swissprot:YJHH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJHH_ECOLI Pfam PF00701 http://pfam.xfam.org/family/PF00701 Phobius swissprot:YJHH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJHH_ECOLI PhylomeDB P39359 http://phylomedb.org/?seqid=P39359 ProteinModelPortal P39359 http://www.proteinmodelportal.org/query/uniprot/P39359 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418718 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418718 SMART SM01130 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01130 SMR P39359 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39359 STRING 511145.b4298 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4298&targetmode=cogs STRING COG0329 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0329&targetmode=cogs UniProtKB YJHH_ECOLI http://www.uniprot.org/uniprot/YJHH_ECOLI UniProtKB-AC P39359 http://www.uniprot.org/uniprot/P39359 charge swissprot:YJHH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJHH_ECOLI eggNOG COG0329 http://eggnogapi.embl.de/nog_data/html/tree/COG0329 eggNOG ENOG4105CDP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CDP epestfind swissprot:YJHH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJHH_ECOLI garnier swissprot:YJHH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJHH_ECOLI helixturnhelix swissprot:YJHH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJHH_ECOLI hmoment swissprot:YJHH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJHH_ECOLI iep swissprot:YJHH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJHH_ECOLI inforesidue swissprot:YJHH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJHH_ECOLI octanol swissprot:YJHH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJHH_ECOLI pepcoil swissprot:YJHH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJHH_ECOLI pepdigest swissprot:YJHH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJHH_ECOLI pepinfo swissprot:YJHH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJHH_ECOLI pepnet swissprot:YJHH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJHH_ECOLI pepstats swissprot:YJHH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJHH_ECOLI pepwheel swissprot:YJHH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJHH_ECOLI pepwindow swissprot:YJHH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJHH_ECOLI sigcleave swissprot:YJHH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJHH_ECOLI ## Database ID URL or Descriptions # AltName MUTY_ECOLI A/G-specific adenine glycosylase # BioGrid 4262359 411 # BioGrid 851767 3 # CDD cd00056 ENDO3c # CDD cd03431 DNA_Glycosylase_C # COFACTOR Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI 49883; Note=Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.; # DrugBank DB00173 Adenine # EcoGene EG10627 mutY # FUNCTION MUTY_ECOLI Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine 7,8-dihydro-8- oxoguanine (8-oxo-dGTP). # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_function GO:0016787 hydrolase activity; IDA:EcoCyc. # GO_function GO:0019104 DNA N-glycosylase activity; IEA:InterPro. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0006284 base-excision repair; IDA:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # Gene3D 1.10.1670.10 -; 1. # Gene3D 1.10.340.30 -; 1. # Gene3D 3.90.79.10 -; 1. # IntAct P17802 11 # InterPro IPR000445 HhH_motif # InterPro IPR003265 HhH-GPD_domain # InterPro IPR003651 Endouclease3_FeS-loop_motif # InterPro IPR004035 Endouclease-III_FeS-bd_BS # InterPro IPR004036 Endonuclease-III-like_CS2 # InterPro IPR005760 A/G_AdeGlyc_MutY # InterPro IPR011257 DNA_glycosylase # InterPro IPR015797 NUDIX_hydrolase_dom-like # InterPro IPR023170 HTH_base_excis_C # InterPro IPR029119 MutY_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko03410 Base excision repair # Organism MUTY_ECOLI Escherichia coli (strain K12) # PATRIC 32121336 VBIEscCol129921_3056 # PDB 1KG2 X-ray; 1.20 A; A=1-225 # PDB 1KG3 X-ray; 1.55 A; A=1-225 # PDB 1KG4 X-ray; 1.60 A; A=1-225 # PDB 1KG5 X-ray; 1.35 A; A=1-225 # PDB 1KG6 X-ray; 1.50 A; A=1-225 # PDB 1KG7 X-ray; 1.50 A; A=1-225 # PDB 1KQJ X-ray; 1.70 A; A=1-225 # PDB 1MUD X-ray; 1.80 A; A=1-225 # PDB 1MUN X-ray; 1.20 A; A=1-225 # PDB 1MUY X-ray; 1.40 A; A=1-225 # PDB 1WEF X-ray; 1.90 A; A=1-225 # PDB 1WEG X-ray; 1.80 A; A=1-225 # PDB 1WEI X-ray; 1.45 A; A=1-225 # PIR B38535 B38535 # PROSITE PS00764 ENDONUCLEASE_III_1 # PROSITE PS01155 ENDONUCLEASE_III_2 # Pfam PF00633 HHH # Pfam PF00730 HhH-GPD # Pfam PF10576 EndIII_4Fe-2S # Pfam PF14815 NUDIX_4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MUTY_ECOLI Adenine DNA glycosylase # RefSeq NP_417436 NC_000913.3 # RefSeq WP_001321419 NZ_LN832404.1 # SIMILARITY Belongs to the Nth/MutY family. {ECO 0000305}. # SMART SM00478 ENDO3c # SMART SM00525 FES # SUPFAM SSF48150 SSF48150 # SUPFAM SSF55811 SSF55811 # TIGRFAMs TIGR01084 mutY # eggNOG COG1194 LUCA # eggNOG ENOG4105CEN Bacteria BLAST swissprot:MUTY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MUTY_ECOLI BioCyc ECOL316407:JW2928-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2928-MONOMER BioCyc EcoCyc:EG10627-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10627-MONOMER COG COG1194 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1194 DIP DIP-10289N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10289N DOI 10.1038/4168 http://dx.doi.org/10.1038/4168 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/18.13.3841 http://dx.doi.org/10.1093/nar/18.13.3841 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB00173 http://www.drugbank.ca/drugs/DB00173 EC_number EC:3.2.2.- http://www.genome.jp/dbget-bin/www_bget?EC:3.2.2.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M59471 http://www.ebi.ac.uk/ena/data/view/M59471 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EMBL X52391 http://www.ebi.ac.uk/ena/data/view/X52391 ENZYME 3.2.2.- http://enzyme.expasy.org/EC/3.2.2.- EchoBASE EB0622 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0622 EcoGene EG10627 http://www.ecogene.org/geneInfo.php?eg_id=EG10627 EnsemblBacteria AAC75998 http://www.ensemblgenomes.org/id/AAC75998 EnsemblBacteria AAC75998 http://www.ensemblgenomes.org/id/AAC75998 EnsemblBacteria BAE77024 http://www.ensemblgenomes.org/id/BAE77024 EnsemblBacteria BAE77024 http://www.ensemblgenomes.org/id/BAE77024 EnsemblBacteria BAE77024 http://www.ensemblgenomes.org/id/BAE77024 EnsemblBacteria b2961 http://www.ensemblgenomes.org/id/b2961 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0016787 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016787 GO_function GO:0019104 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019104 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0006284 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006284 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 1.10.1670.10 http://www.cathdb.info/version/latest/superfamily/1.10.1670.10 Gene3D 1.10.340.30 http://www.cathdb.info/version/latest/superfamily/1.10.340.30 Gene3D 3.90.79.10 http://www.cathdb.info/version/latest/superfamily/3.90.79.10 GeneID 947447 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947447 HOGENOM HOG000028744 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000028744&db=HOGENOM6 InParanoid P17802 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P17802 IntAct P17802 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P17802* IntEnz 3.2.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.2.2 InterPro IPR000445 http://www.ebi.ac.uk/interpro/entry/IPR000445 InterPro IPR003265 http://www.ebi.ac.uk/interpro/entry/IPR003265 InterPro IPR003651 http://www.ebi.ac.uk/interpro/entry/IPR003651 InterPro IPR004035 http://www.ebi.ac.uk/interpro/entry/IPR004035 InterPro IPR004036 http://www.ebi.ac.uk/interpro/entry/IPR004036 InterPro IPR005760 http://www.ebi.ac.uk/interpro/entry/IPR005760 InterPro IPR011257 http://www.ebi.ac.uk/interpro/entry/IPR011257 InterPro IPR015797 http://www.ebi.ac.uk/interpro/entry/IPR015797 InterPro IPR023170 http://www.ebi.ac.uk/interpro/entry/IPR023170 InterPro IPR029119 http://www.ebi.ac.uk/interpro/entry/IPR029119 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW2928 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2928 KEGG_Gene eco:b2961 http://www.genome.jp/dbget-bin/www_bget?eco:b2961 KEGG_Orthology KO:K03575 http://www.genome.jp/dbget-bin/www_bget?KO:K03575 KEGG_Pathway ko03410 http://www.genome.jp/kegg-bin/show_pathway?ko03410 MINT MINT-1240449 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1240449 OMA EADWLWY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EADWLWY PDB 1KG2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1KG2 PDB 1KG3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1KG3 PDB 1KG4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1KG4 PDB 1KG5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1KG5 PDB 1KG6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1KG6 PDB 1KG7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1KG7 PDB 1KQJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1KQJ PDB 1MUD http://www.ebi.ac.uk/pdbe-srv/view/entry/1MUD PDB 1MUN http://www.ebi.ac.uk/pdbe-srv/view/entry/1MUN PDB 1MUY http://www.ebi.ac.uk/pdbe-srv/view/entry/1MUY PDB 1WEF http://www.ebi.ac.uk/pdbe-srv/view/entry/1WEF PDB 1WEG http://www.ebi.ac.uk/pdbe-srv/view/entry/1WEG PDB 1WEI http://www.ebi.ac.uk/pdbe-srv/view/entry/1WEI PDBsum 1KG2 http://www.ebi.ac.uk/pdbsum/1KG2 PDBsum 1KG3 http://www.ebi.ac.uk/pdbsum/1KG3 PDBsum 1KG4 http://www.ebi.ac.uk/pdbsum/1KG4 PDBsum 1KG5 http://www.ebi.ac.uk/pdbsum/1KG5 PDBsum 1KG6 http://www.ebi.ac.uk/pdbsum/1KG6 PDBsum 1KG7 http://www.ebi.ac.uk/pdbsum/1KG7 PDBsum 1KQJ http://www.ebi.ac.uk/pdbsum/1KQJ PDBsum 1MUD http://www.ebi.ac.uk/pdbsum/1MUD PDBsum 1MUN http://www.ebi.ac.uk/pdbsum/1MUN PDBsum 1MUY http://www.ebi.ac.uk/pdbsum/1MUY PDBsum 1WEF http://www.ebi.ac.uk/pdbsum/1WEF PDBsum 1WEG http://www.ebi.ac.uk/pdbsum/1WEG PDBsum 1WEI http://www.ebi.ac.uk/pdbsum/1WEI PROSITE PS00764 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00764 PROSITE PS01155 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01155 PSORT swissprot:MUTY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MUTY_ECOLI PSORT-B swissprot:MUTY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MUTY_ECOLI PSORT2 swissprot:MUTY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MUTY_ECOLI Pfam PF00633 http://pfam.xfam.org/family/PF00633 Pfam PF00730 http://pfam.xfam.org/family/PF00730 Pfam PF10576 http://pfam.xfam.org/family/PF10576 Pfam PF14815 http://pfam.xfam.org/family/PF14815 Phobius swissprot:MUTY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MUTY_ECOLI PhylomeDB P17802 http://phylomedb.org/?seqid=P17802 ProteinModelPortal P17802 http://www.proteinmodelportal.org/query/uniprot/P17802 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2001994 http://www.ncbi.nlm.nih.gov/pubmed/2001994 PubMed 2197596 http://www.ncbi.nlm.nih.gov/pubmed/2197596 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9846876 http://www.ncbi.nlm.nih.gov/pubmed/9846876 RefSeq NP_417436 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417436 RefSeq WP_001321419 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001321419 SMART SM00478 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00478 SMART SM00525 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00525 SMR P17802 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P17802 STRING 511145.b2961 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2961&targetmode=cogs STRING COG1194 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1194&targetmode=cogs SUPFAM SSF48150 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48150 SUPFAM SSF55811 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55811 TIGRFAMs TIGR01084 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01084 UniProtKB MUTY_ECOLI http://www.uniprot.org/uniprot/MUTY_ECOLI UniProtKB-AC P17802 http://www.uniprot.org/uniprot/P17802 charge swissprot:MUTY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MUTY_ECOLI eggNOG COG1194 http://eggnogapi.embl.de/nog_data/html/tree/COG1194 eggNOG ENOG4105CEN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CEN epestfind swissprot:MUTY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MUTY_ECOLI garnier swissprot:MUTY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MUTY_ECOLI helixturnhelix swissprot:MUTY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MUTY_ECOLI hmoment swissprot:MUTY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MUTY_ECOLI iep swissprot:MUTY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MUTY_ECOLI inforesidue swissprot:MUTY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MUTY_ECOLI octanol swissprot:MUTY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MUTY_ECOLI pepcoil swissprot:MUTY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MUTY_ECOLI pepdigest swissprot:MUTY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MUTY_ECOLI pepinfo swissprot:MUTY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MUTY_ECOLI pepnet swissprot:MUTY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MUTY_ECOLI pepstats swissprot:MUTY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MUTY_ECOLI pepwheel swissprot:MUTY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MUTY_ECOLI pepwindow swissprot:MUTY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MUTY_ECOLI sigcleave swissprot:MUTY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MUTY_ECOLI ## Database ID URL or Descriptions # BioGrid 4263361 11 # CATALYTIC ACTIVITY YFIN_ECOLI 2 GTP = 2 diphosphate + cyclic di-3',5'- guanylate. # CDD cd01949 GGDEF # COFACTOR YFIN_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250}; Note=Binds 1 Mg(2+) ion per monomer. {ECO 0000250}; # DISRUPTION PHENOTYPE Disruption partially suppresses the reduced motility of a yhjH disruption; concomitant disruption of dosC, yegE, yedQ and yfiN completely restores motility, suggesting these 4 genes, together with the c-di-GMP phosphodiesterase YhjH, form a network that regulates cell motility by altering levels of c-di- GMP. {ECO:0000269|PubMed 20303158}. # EcoGene EG12880 yfiN # FUNCTION YFIN_ECOLI Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria. {ECO 0000269|PubMed 20303158}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0004871 signal transducer activity; IEA:InterPro. # GO_function GO:0005525 GTP binding; IEA:UniProtKB-KW. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0052621 diguanylate cyclase activity; IEA:UniProtKB-EC. # GO_process GO:1902201 negative regulation of bacterial-type flagellum-dependent cell motility; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # INDUCTION Expressed at low levels at both 28 and 37 degrees Celsius during transition into stationary phase. {ECO:0000269|PubMed 19332833}. # InterPro IPR000160 GGDEF_dom # InterPro IPR003660 HAMP_dom # InterPro IPR029787 Nucleotide_cyclase # InterPro IPR033417 CHASE8 # Organism YFIN_ECOLI Escherichia coli (strain K12) # PATHWAY YFIN_ECOLI Purine metabolism; 3',5'-cyclic di-GMP biosynthesis. # PATRIC 32120607 VBIEscCol129921_2702 # PIR G65038 G65038 # PROSITE PS50885 HAMP # PROSITE PS50887 GGDEF # Pfam PF00990 GGDEF # Pfam PF17152 CHASE8 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFIN_ECOLI Probable diguanylate cyclase YfiN # RefSeq NP_417095 NC_000913.3 # SIMILARITY Contains 1 GGDEF domain. {ECO:0000255|PROSITE- ProRule PRU00095}. # SIMILARITY Contains 1 HAMP domain. {ECO:0000255|PROSITE- ProRule PRU00102}. # SMART SM00267 GGDEF # SUBCELLULAR LOCATION YFIN_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT Homodimer. {ECO 0000250}. # SUPFAM SSF55073 SSF55073 # TIGRFAMs TIGR00254 GGDEF # eggNOG COG2199 LUCA # eggNOG ENOG4108KHX Bacteria BLAST swissprot:YFIN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFIN_ECOLI BioCyc ECOL316407:JW2585-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2585-MONOMER BioCyc EcoCyc:EG12880-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12880-MONOMER DOI 10.1016/j.cell.2010.01.018 http://dx.doi.org/10.1016/j.cell.2010.01.018 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1099/mic.0.024257-0 http://dx.doi.org/10.1099/mic.0.024257-0 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.7.65 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.65 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X01818 http://www.ebi.ac.uk/ena/data/view/X01818 ENZYME 2.7.7.65 http://enzyme.expasy.org/EC/2.7.7.65 EchoBASE EB2718 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2718 EcoGene EG12880 http://www.ecogene.org/geneInfo.php?eg_id=EG12880 EnsemblBacteria AAC75653 http://www.ensemblgenomes.org/id/AAC75653 EnsemblBacteria AAC75653 http://www.ensemblgenomes.org/id/AAC75653 EnsemblBacteria BAA16489 http://www.ensemblgenomes.org/id/BAA16489 EnsemblBacteria BAA16489 http://www.ensemblgenomes.org/id/BAA16489 EnsemblBacteria BAA16489 http://www.ensemblgenomes.org/id/BAA16489 EnsemblBacteria b2604 http://www.ensemblgenomes.org/id/b2604 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0052621 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052621 GO_process GO:1902201 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902201 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 947091 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947091 HOGENOM HOG000217416 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000217416&db=HOGENOM6 InParanoid P46139 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P46139 IntEnz 2.7.7.65 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.65 InterPro IPR000160 http://www.ebi.ac.uk/interpro/entry/IPR000160 InterPro IPR003660 http://www.ebi.ac.uk/interpro/entry/IPR003660 InterPro IPR029787 http://www.ebi.ac.uk/interpro/entry/IPR029787 InterPro IPR033417 http://www.ebi.ac.uk/interpro/entry/IPR033417 KEGG_Gene ecj:JW2585 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2585 KEGG_Gene eco:b2604 http://www.genome.jp/dbget-bin/www_bget?eco:b2604 OMA GNDFNAL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GNDFNAL PROSITE PS50885 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50885 PROSITE PS50887 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50887 PSORT swissprot:YFIN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFIN_ECOLI PSORT-B swissprot:YFIN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFIN_ECOLI PSORT2 swissprot:YFIN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFIN_ECOLI Pfam PF00990 http://pfam.xfam.org/family/PF00990 Pfam PF17152 http://pfam.xfam.org/family/PF17152 Phobius swissprot:YFIN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFIN_ECOLI ProteinModelPortal P46139 http://www.proteinmodelportal.org/query/uniprot/P46139 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19332833 http://www.ncbi.nlm.nih.gov/pubmed/19332833 PubMed 20303158 http://www.ncbi.nlm.nih.gov/pubmed/20303158 PubMed 6357787 http://www.ncbi.nlm.nih.gov/pubmed/6357787 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417095 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417095 SMART SM00267 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00267 SMR P46139 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P46139 STRING 511145.b2604 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2604&targetmode=cogs SUPFAM SSF55073 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55073 TIGRFAMs TIGR00254 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00254 UniProtKB YFIN_ECOLI http://www.uniprot.org/uniprot/YFIN_ECOLI UniProtKB-AC P46139 http://www.uniprot.org/uniprot/P46139 charge swissprot:YFIN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFIN_ECOLI eggNOG COG2199 http://eggnogapi.embl.de/nog_data/html/tree/COG2199 eggNOG ENOG4108KHX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108KHX epestfind swissprot:YFIN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFIN_ECOLI garnier swissprot:YFIN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFIN_ECOLI helixturnhelix swissprot:YFIN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFIN_ECOLI hmoment swissprot:YFIN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFIN_ECOLI iep swissprot:YFIN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFIN_ECOLI inforesidue swissprot:YFIN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFIN_ECOLI octanol swissprot:YFIN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFIN_ECOLI pepcoil swissprot:YFIN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFIN_ECOLI pepdigest swissprot:YFIN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFIN_ECOLI pepinfo swissprot:YFIN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFIN_ECOLI pepnet swissprot:YFIN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFIN_ECOLI pepstats swissprot:YFIN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFIN_ECOLI pepwheel swissprot:YFIN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFIN_ECOLI pepwindow swissprot:YFIN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFIN_ECOLI sigcleave swissprot:YFIN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFIN_ECOLI ## Database ID URL or Descriptions # AltName NANS_ECOLI Probable 9-O-acetyl-N-acetylneuraminate esterase # AltName NANS_ECOLI Probable sialyl esterase NanS # BioGrid 4259373 13 # DISRUPTION PHENOTYPE Cells lacking this gene cannot grow on Neu5,9Ac2 as the sole carbon source, in contrast to wild-type, but grow as well as wild-type on glycerol or on N-acetylneuraminate (Neu5Ac). {ECO:0000269|PubMed 19749043}. # EcoGene EG12561 nanS # FUNCTION NANS_ECOLI Probably catalyzes the hydrolysis of the 9-O-acetyl group of 9-O-acetyl-N-acetylneuraminate (Neu5,9Ac2). Is required for growth of E.coli on Neu5,9Ac2, an alternative sialic acid commonly found in mammalian host mucosal sites, in particular in the human intestine. {ECO 0000269|PubMed 19749043}. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_function GO:0016787 hydrolase activity; IEA:UniProtKB-KW. # GO_process GO:0005975 carbohydrate metabolic process; IEA:UniProtKB-KW. # GO_process GO:0019752 carboxylic acid metabolic process; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0044281 small molecule metabolic process # INDUCTION Induced by N-acetylneuraminate and modulated by N- acetylglucosamine, via the NanR and NagC regulators. {ECO:0000305|PubMed 15743943}. # InterPro IPR005181 SASA # InterPro IPR013830 SGNH_hydro # Organism NANS_ECOLI Escherichia coli (strain K12) # PATRIC 32124212 VBIEscCol129921_4449 # PIR S56534 S56534 # Pfam PF03629 SASA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NANS_ECOLI Probable 9-O-acetyl-N-acetylneuraminic acid deacetylase # RefSeq NP_418729 NC_000913.3 # RefSeq WP_000991438 NZ_LN832404.1 # SUBCELLULAR LOCATION NANS_ECOLI Periplasm {ECO 0000305|PubMed 19749043}. # SUPFAM SSF52266 SSF52266; 2 BLAST swissprot:NANS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NANS_ECOLI BioCyc ECOL316407:JW4272-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4272-MONOMER BioCyc EcoCyc:G7919-MONOMER http://biocyc.org/getid?id=EcoCyc:G7919-MONOMER COG COG2801 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2801 DIP DIP-12627N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12627N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01000-09 http://dx.doi.org/10.1128/JB.01000-09 DOI 10.1128/JB.187.6.1959-1965.2005 http://dx.doi.org/10.1128/JB.187.6.1959-1965.2005 EC_number EC:3.1.1.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 3.1.1.- http://enzyme.expasy.org/EC/3.1.1.- EchoBASE EB2449 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2449 EcoGene EG12561 http://www.ecogene.org/geneInfo.php?eg_id=EG12561 EnsemblBacteria AAC77265 http://www.ensemblgenomes.org/id/AAC77265 EnsemblBacteria AAC77265 http://www.ensemblgenomes.org/id/AAC77265 EnsemblBacteria BAE78302 http://www.ensemblgenomes.org/id/BAE78302 EnsemblBacteria BAE78302 http://www.ensemblgenomes.org/id/BAE78302 EnsemblBacteria BAE78302 http://www.ensemblgenomes.org/id/BAE78302 EnsemblBacteria b4309 http://www.ensemblgenomes.org/id/b4309 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0016787 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016787 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GO_process GO:0019752 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019752 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 948835 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948835 HOGENOM HOG000127484 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000127484&db=HOGENOM6 InParanoid P39370 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39370 IntEnz 3.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.1 InterPro IPR005181 http://www.ebi.ac.uk/interpro/entry/IPR005181 InterPro IPR013830 http://www.ebi.ac.uk/interpro/entry/IPR013830 KEGG_Gene ecj:JW4272 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4272 KEGG_Gene eco:b4309 http://www.genome.jp/dbget-bin/www_bget?eco:b4309 KEGG_Orthology KO:K07497 http://www.genome.jp/dbget-bin/www_bget?KO:K07497 OMA NWTTSLR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NWTTSLR PSORT swissprot:NANS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NANS_ECOLI PSORT-B swissprot:NANS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NANS_ECOLI PSORT2 swissprot:NANS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NANS_ECOLI Pfam PF03629 http://pfam.xfam.org/family/PF03629 Phobius swissprot:NANS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NANS_ECOLI ProteinModelPortal P39370 http://www.proteinmodelportal.org/query/uniprot/P39370 PubMed 15743943 http://www.ncbi.nlm.nih.gov/pubmed/15743943 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19749043 http://www.ncbi.nlm.nih.gov/pubmed/19749043 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418729 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418729 RefSeq WP_000991438 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000991438 SMR P39370 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39370 STRING 511145.b4309 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4309&targetmode=cogs STRING COG2801 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2801&targetmode=cogs SUPFAM SSF52266 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52266 UniProtKB NANS_ECOLI http://www.uniprot.org/uniprot/NANS_ECOLI UniProtKB-AC P39370 http://www.uniprot.org/uniprot/P39370 charge swissprot:NANS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NANS_ECOLI epestfind swissprot:NANS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NANS_ECOLI garnier swissprot:NANS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NANS_ECOLI helixturnhelix swissprot:NANS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NANS_ECOLI hmoment swissprot:NANS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NANS_ECOLI iep swissprot:NANS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NANS_ECOLI inforesidue swissprot:NANS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NANS_ECOLI octanol swissprot:NANS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NANS_ECOLI pepcoil swissprot:NANS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NANS_ECOLI pepdigest swissprot:NANS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NANS_ECOLI pepinfo swissprot:NANS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NANS_ECOLI pepnet swissprot:NANS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NANS_ECOLI pepstats swissprot:NANS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NANS_ECOLI pepwheel swissprot:NANS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NANS_ECOLI pepwindow swissprot:NANS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NANS_ECOLI sigcleave swissprot:NANS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NANS_ECOLI ## Database ID URL or Descriptions # BioGrid 4263504 531 # EcoGene EG11630 potG # FUNCTION POTG_ECOLI Part of the binding-protein-dependent transport system for putrescine. Probably responsible for energy coupling to the transport system. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IEA:InterPro. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0015594 putrescine-importing ATPase activity; IMP:EcoCyc. # GO_process GO:0015847 putrescine transport; IMP:EcoCyc. # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # Gene3D 3.40.50.300 -; 1. # IntAct P31134 3 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR005893 Sp_pt_ABC_ATP-bd # InterPro IPR008995 Mo/tungstate-bd_C_term_dom # InterPro IPR013611 Transp-assoc_OB_typ2 # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00300 Putrescine transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism POTG_ECOLI Escherichia coli (strain K12) # PATRIC 32116915 VBIEscCol129921_0883 # PIR B45313 B45313 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # Pfam PF00005 ABC_tran # Pfam PF08402 TOBE_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName POTG_ECOLI Putrescine transport ATP-binding protein PotG # RefSeq NP_415376 NC_000913.3 # RefSeq WP_000996005 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA24410.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ABC transporter superfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA # SUBCELLULAR LOCATION POTG_ECOLI Cell inner membrane {ECO 0000305}; Peripheral membrane protein {ECO 0000305}. # SUPFAM SSF50331 SSF50331 # SUPFAM SSF52540 SSF52540 # TCDB 3.A.1.11 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR01187 potA # eggNOG COG3842 LUCA # eggNOG ENOG4105C53 Bacteria BLAST swissprot:POTG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:POTG_ECOLI BioCyc ECOL316407:JW5818-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5818-MONOMER BioCyc EcoCyc:POTG-MONOMER http://biocyc.org/getid?id=EcoCyc:POTG-MONOMER BioCyc MetaCyc:POTG-MONOMER http://biocyc.org/getid?id=MetaCyc:POTG-MONOMER COG COG3842 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3842 DIP DIP-10532N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10532N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M93239 http://www.ebi.ac.uk/ena/data/view/M93239 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1587 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1587 EcoGene EG11630 http://www.ecogene.org/geneInfo.php?eg_id=EG11630 EnsemblBacteria AAC73942 http://www.ensemblgenomes.org/id/AAC73942 EnsemblBacteria AAC73942 http://www.ensemblgenomes.org/id/AAC73942 EnsemblBacteria BAA35566 http://www.ensemblgenomes.org/id/BAA35566 EnsemblBacteria BAA35566 http://www.ensemblgenomes.org/id/BAA35566 EnsemblBacteria BAA35566 http://www.ensemblgenomes.org/id/BAA35566 EnsemblBacteria b0855 http://www.ensemblgenomes.org/id/b0855 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0015594 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015594 GO_process GO:0015847 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015847 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945476 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945476 InParanoid P31134 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31134 IntAct P31134 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31134* InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR005893 http://www.ebi.ac.uk/interpro/entry/IPR005893 InterPro IPR008995 http://www.ebi.ac.uk/interpro/entry/IPR008995 InterPro IPR013611 http://www.ebi.ac.uk/interpro/entry/IPR013611 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5818 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5818 KEGG_Gene eco:b0855 http://www.genome.jp/dbget-bin/www_bget?eco:b0855 KEGG_Orthology KO:K11076 http://www.genome.jp/dbget-bin/www_bget?KO:K11076 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA AVASTEH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AVASTEH PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:POTG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:POTG_ECOLI PSORT-B swissprot:POTG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:POTG_ECOLI PSORT2 swissprot:POTG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:POTG_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Pfam PF08402 http://pfam.xfam.org/family/PF08402 Phobius swissprot:POTG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:POTG_ECOLI PhylomeDB P31134 http://phylomedb.org/?seqid=P31134 ProteinModelPortal P31134 http://www.proteinmodelportal.org/query/uniprot/P31134 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8416922 http://www.ncbi.nlm.nih.gov/pubmed/8416922 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415376 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415376 RefSeq WP_000996005 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000996005 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P31134 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31134 STRING 511145.b0855 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0855&targetmode=cogs STRING COG3842 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3842&targetmode=cogs SUPFAM SSF50331 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50331 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.11 http://www.tcdb.org/search/result.php?tc=3.A.1.11 TIGRFAMs TIGR01187 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01187 UniProtKB POTG_ECOLI http://www.uniprot.org/uniprot/POTG_ECOLI UniProtKB-AC P31134 http://www.uniprot.org/uniprot/P31134 charge swissprot:POTG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:POTG_ECOLI eggNOG COG3842 http://eggnogapi.embl.de/nog_data/html/tree/COG3842 eggNOG ENOG4105C53 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C53 epestfind swissprot:POTG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:POTG_ECOLI garnier swissprot:POTG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:POTG_ECOLI helixturnhelix swissprot:POTG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:POTG_ECOLI hmoment swissprot:POTG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:POTG_ECOLI iep swissprot:POTG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:POTG_ECOLI inforesidue swissprot:POTG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:POTG_ECOLI octanol swissprot:POTG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:POTG_ECOLI pepcoil swissprot:POTG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:POTG_ECOLI pepdigest swissprot:POTG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:POTG_ECOLI pepinfo swissprot:POTG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:POTG_ECOLI pepnet swissprot:POTG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:POTG_ECOLI pepstats swissprot:POTG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:POTG_ECOLI pepwheel swissprot:POTG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:POTG_ECOLI pepwindow swissprot:POTG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:POTG_ECOLI sigcleave swissprot:POTG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:POTG_ECOLI ## Database ID URL or Descriptions # EcoGene EG14481 yoaK # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # INDUCTION YOAK_ECOLI Constitutively expressed, may be induced at pH 5.5, repressed by thiol oxidant diamide (at protein level). {ECO 0000269|PubMed 19121005, ECO 0000269|PubMed 19734316}. # Organism YOAK_ECOLI Escherichia coli (strain K12) # PATRIC 32118903 VBIEscCol129921_1869 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YOAK_ECOLI Uncharacterized membrane protein YoaK # RefSeq WP_001219350 NZ_LN832404.1 # RefSeq YP_002791242 NC_000913.3 # SUBCELLULAR LOCATION YOAK_ECOLI Cell inner membrane {ECO 0000305|PubMed 19121005, ECO 0000305|PubMed 21778229}; Single-pass membrane protein {ECO 0000269|PubMed 19121005, ECO 0000269|PubMed 21778229}. Note=May be able to insert into the membrane in both orientations. Relies on YidC for insertion. # eggNOG ENOG4106G4W Bacteria # eggNOG ENOG410Y5TS LUCA BLAST swissprot:YOAK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YOAK_ECOLI BioCyc EcoCyc:MONOMER0-2876 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2876 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M111.245696 http://dx.doi.org/10.1074/jbc.M111.245696 DOI 10.1111/j.1365-2958.2008.06495.x http://dx.doi.org/10.1111/j.1365-2958.2008.06495.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00872-09 http://dx.doi.org/10.1128/JB.00872-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14481 http://www.ecogene.org/geneInfo.php?eg_id=EG14481 EnsemblBacteria ACO59994 http://www.ensemblgenomes.org/id/ACO59994 EnsemblBacteria ACO59994 http://www.ensemblgenomes.org/id/ACO59994 EnsemblBacteria b4676 http://www.ensemblgenomes.org/id/b4676 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 7751647 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7751647 HOGENOM HOG000009485 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009485&db=HOGENOM6 KEGG_Gene eco:b4676 http://www.genome.jp/dbget-bin/www_bget?eco:b4676 PSORT swissprot:YOAK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YOAK_ECOLI PSORT-B swissprot:YOAK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YOAK_ECOLI PSORT2 swissprot:YOAK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YOAK_ECOLI Phobius swissprot:YOAK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YOAK_ECOLI PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19121005 http://www.ncbi.nlm.nih.gov/pubmed/19121005 PubMed 19734316 http://www.ncbi.nlm.nih.gov/pubmed/19734316 PubMed 21778229 http://www.ncbi.nlm.nih.gov/pubmed/21778229 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001219350 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001219350 RefSeq YP_002791242 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_002791242 STRING 511145.b4676 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4676&targetmode=cogs UniProtKB YOAK_ECOLI http://www.uniprot.org/uniprot/YOAK_ECOLI UniProtKB-AC C1P602 http://www.uniprot.org/uniprot/C1P602 charge swissprot:YOAK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YOAK_ECOLI eggNOG ENOG4106G4W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106G4W eggNOG ENOG410Y5TS http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y5TS epestfind swissprot:YOAK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YOAK_ECOLI garnier swissprot:YOAK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YOAK_ECOLI helixturnhelix swissprot:YOAK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YOAK_ECOLI hmoment swissprot:YOAK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YOAK_ECOLI iep swissprot:YOAK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YOAK_ECOLI inforesidue swissprot:YOAK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YOAK_ECOLI octanol swissprot:YOAK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YOAK_ECOLI pepcoil swissprot:YOAK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YOAK_ECOLI pepdigest swissprot:YOAK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YOAK_ECOLI pepinfo swissprot:YOAK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YOAK_ECOLI pepnet swissprot:YOAK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YOAK_ECOLI pepstats swissprot:YOAK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YOAK_ECOLI pepwheel swissprot:YOAK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YOAK_ECOLI pepwindow swissprot:YOAK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YOAK_ECOLI sigcleave swissprot:YOAK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YOAK_ECOLI ## Database ID URL or Descriptions # FUNCTION INSC7_ECOLI Involved in the transposition of the insertion sequence IS2. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 1.10.10.60 -; 1. # InterPro IPR002514 Transposase_8 # InterPro IPR009057 Homeodomain-like # Organism INSC7_ECOLI Escherichia coli (strain K12) # Pfam PF01527 HTH_Tnp_1 # RecName INSC7_ECOLI Transposase InsC for insertion element IS2 on F plasmid # RefSeq NP_061400 NC_002483.1 # RefSeq WP_000567766 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA97891.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the transposase 8 family. {ECO 0000305}. # SUPFAM SSF46689 SSF46689 # eggNOG COG2963 LUCA # eggNOG ENOG4108ZQS Bacteria BLAST swissprot:INSC7_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSC7_ECOLI EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 GeneID 1263543 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263543 InterPro IPR002514 http://www.ebi.ac.uk/interpro/entry/IPR002514 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 PSORT swissprot:INSC7_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSC7_ECOLI PSORT-B swissprot:INSC7_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSC7_ECOLI PSORT2 swissprot:INSC7_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSC7_ECOLI Pfam PF01527 http://pfam.xfam.org/family/PF01527 Phobius swissprot:INSC7_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSC7_ECOLI PhylomeDB P0CF46 http://phylomedb.org/?seqid=P0CF46 ProteinModelPortal P0CF46 http://www.proteinmodelportal.org/query/uniprot/P0CF46 RefSeq NP_061400 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061400 RefSeq WP_000567766 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000567766 STRING 511145.b4272 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4272&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 UniProtKB INSC7_ECOLI http://www.uniprot.org/uniprot/INSC7_ECOLI UniProtKB-AC P0CF46 http://www.uniprot.org/uniprot/P0CF46 charge swissprot:INSC7_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSC7_ECOLI eggNOG COG2963 http://eggnogapi.embl.de/nog_data/html/tree/COG2963 eggNOG ENOG4108ZQS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZQS epestfind swissprot:INSC7_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSC7_ECOLI garnier swissprot:INSC7_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSC7_ECOLI helixturnhelix swissprot:INSC7_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSC7_ECOLI hmoment swissprot:INSC7_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSC7_ECOLI iep swissprot:INSC7_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSC7_ECOLI inforesidue swissprot:INSC7_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSC7_ECOLI octanol swissprot:INSC7_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSC7_ECOLI pepcoil swissprot:INSC7_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSC7_ECOLI pepdigest swissprot:INSC7_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSC7_ECOLI pepinfo swissprot:INSC7_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSC7_ECOLI pepnet swissprot:INSC7_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSC7_ECOLI pepstats swissprot:INSC7_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSC7_ECOLI pepwheel swissprot:INSC7_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSC7_ECOLI pepwindow swissprot:INSC7_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSC7_ECOLI sigcleave swissprot:INSC7_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSC7_ECOLI ## Database ID URL or Descriptions # AltName DXR_ECOLI 1-deoxyxylulose-5-phosphate reductoisomerase # AltName DXR_ECOLI 2-C-methyl-D-erythritol 4-phosphate synthase # BIOPHYSICOCHEMICAL PROPERTIES DXR_ECOLI Kinetic parameters KM=250 uM for DXP {ECO 0000269|PubMed 10787409}; Note=Measured in the presence of manganese ions.; pH dependence Optimum pH is 7.0-8.5. {ECO 0000269|PubMed 10787409}; Temperature dependence Optimum temperature is 40-60 degrees Celsius. {ECO 0000269|PubMed 10787409}; # BRENDA 1.1.1.267 2026 # BioGrid 4259751 202 # CATALYTIC ACTIVITY DXR_ECOLI 2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + NADPH. # COFACTOR DXR_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Name=Co(2+); Xref=ChEBI CHEBI 48828; Note=Divalent cation. Prefers Mg(2+), Mn(2+) or Co(2+).; # ENZYME REGULATION DXR_ECOLI Inhibited by fosmidomycin. # EcoGene EG12715 dxr # FUNCTION DXR_ECOLI Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP). # GO_function GO:0030145 manganese ion binding; IDA:EcoCyc. # GO_function GO:0030604 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0070402 NADPH binding; IBA:GO_Central. # GO_process GO:0019288 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway; IMP:EcoCyc. # GO_process GO:0051484 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process; IBA:GO_Central. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.720 -; 1. # HAMAP MF_00183 DXP_reductoisom # IntAct P45568 6 # InterPro IPR003821 DXP_reductoisomerase # InterPro IPR013512 DXP_reductoisomerase_N # InterPro IPR013644 DXP_reductoisomerase_C # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR026877 DXPR_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00900 Terpenoid backbone biosynthesis # Organism DXR_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30525 PTHR30525 # PATHWAY Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1- deoxy-D-xylulose 5-phosphate step 1/6. # PATRIC 32115455 VBIEscCol129921_0179 # PDB 1JVS X-ray; 2.20 A; A/B=2-398 # PDB 1K5H X-ray; 2.50 A; A/B/C=1-398 # PDB 1ONN X-ray; 2.60 A; A/B=1-398 # PDB 1ONO X-ray; 2.50 A; A/B=1-398 # PDB 1ONP X-ray; 2.50 A; A/B=1-398 # PDB 1Q0H X-ray; 2.20 A; A=1-398 # PDB 1Q0L X-ray; 2.65 A; A=1-398 # PDB 1Q0Q X-ray; 1.90 A; A/B=1-398 # PDB 1T1R X-ray; 2.30 A; A/B=2-398 # PDB 1T1S X-ray; 2.40 A; A/B=2-398 # PDB 2EGH X-ray; 2.20 A; A/B=2-398 # PDB 3ANL X-ray; 2.10 A; A/B=2-398 # PDB 3ANM X-ray; 2.00 A; A/B=2-398 # PDB 3ANN X-ray; 2.00 A; A/B=2-398 # PDB 3R0I X-ray; 2.10 A; A/B=1-398 # PIR E64741 E64741 # PIRSF PIRSF006205 Dxp_reductismrs # Pfam PF02670 DXP_reductoisom # Pfam PF08436 DXP_redisom_C # Pfam PF13288 DXPR_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DXR_ECOLI 1-deoxy-D-xylulose 5-phosphate reductoisomerase # RefSeq NP_414715 NC_000913.3 # RefSeq WP_000811923 NZ_LN832404.1 # SIMILARITY Belongs to the DXR family. {ECO 0000305}. # SUBUNIT DXR_ECOLI Homodimer. {ECO 0000269|PubMed 11741911, ECO 0000269|PubMed 11872159, ECO 0000269|PubMed 12621040, ECO 0000269|PubMed 15339150, ECO 0000269|PubMed 15567415}. # SUPFAM SSF51735 SSF51735 # SUPFAM SSF69055 SSF69055 # TIGRFAMs TIGR00243 Dxr # UniPathway UPA00056 UER00092 # eggNOG COG0743 LUCA # eggNOG ENOG4105CEA Bacteria BLAST swissprot:DXR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DXR_ECOLI BioCyc ECOL316407:JW0168-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0168-MONOMER BioCyc EcoCyc:DXPREDISOM-MONOMER http://biocyc.org/getid?id=EcoCyc:DXPREDISOM-MONOMER BioCyc MetaCyc:DXPREDISOM-MONOMER http://biocyc.org/getid?id=MetaCyc:DXPREDISOM-MONOMER COG COG0743 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0743 DIP DIP-9484N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9484N DOI 10.1016/S0014-5793(99)01743-3 http://dx.doi.org/10.1016/S0014-5793(99)01743-3 DOI 10.1016/j.jmb.2004.10.030 http://dx.doi.org/10.1016/j.jmb.2004.10.030 DOI 10.1021/ja040126m http://dx.doi.org/10.1021/ja040126m DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.95.17.9879 http://dx.doi.org/10.1073/pnas.95.17.9879 DOI 10.1074/jbc.M001820200 http://dx.doi.org/10.1074/jbc.M001820200 DOI 10.1074/jbc.M109500200 http://dx.doi.org/10.1074/jbc.M109500200 DOI 10.1074/jbc.M300993200 http://dx.doi.org/10.1074/jbc.M300993200 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1093/oxfordjournals.jbchem.a003105 http://dx.doi.org/10.1093/oxfordjournals.jbchem.a003105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.267 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.267 EMBL AB013300 http://www.ebi.ac.uk/ena/data/view/AB013300 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D13334 http://www.ebi.ac.uk/ena/data/view/D13334 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 ENZYME 1.1.1.267 http://enzyme.expasy.org/EC/1.1.1.267 EchoBASE EB2575 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2575 EcoGene EG12715 http://www.ecogene.org/geneInfo.php?eg_id=EG12715 EnsemblBacteria AAC73284 http://www.ensemblgenomes.org/id/AAC73284 EnsemblBacteria AAC73284 http://www.ensemblgenomes.org/id/AAC73284 EnsemblBacteria BAA77848 http://www.ensemblgenomes.org/id/BAA77848 EnsemblBacteria BAA77848 http://www.ensemblgenomes.org/id/BAA77848 EnsemblBacteria BAA77848 http://www.ensemblgenomes.org/id/BAA77848 EnsemblBacteria b0173 http://www.ensemblgenomes.org/id/b0173 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_function GO:0030604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030604 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0070402 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070402 GO_process GO:0019288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019288 GO_process GO:0051484 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051484 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 945019 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945019 HAMAP MF_00183 http://hamap.expasy.org/unirule/MF_00183 HOGENOM HOG000007221 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000007221&db=HOGENOM6 InParanoid P45568 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45568 IntAct P45568 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45568* IntEnz 1.1.1.267 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.267 InterPro IPR003821 http://www.ebi.ac.uk/interpro/entry/IPR003821 InterPro IPR013512 http://www.ebi.ac.uk/interpro/entry/IPR013512 InterPro IPR013644 http://www.ebi.ac.uk/interpro/entry/IPR013644 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR026877 http://www.ebi.ac.uk/interpro/entry/IPR026877 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0168 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0168 KEGG_Gene eco:b0173 http://www.genome.jp/dbget-bin/www_bget?eco:b0173 KEGG_Orthology KO:K00099 http://www.genome.jp/dbget-bin/www_bget?KO:K00099 KEGG_Pathway ko00900 http://www.genome.jp/kegg-bin/show_pathway?ko00900 KEGG_Reaction rn:R05688 http://www.genome.jp/dbget-bin/www_bget?rn:R05688 OMA GFCPLSE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GFCPLSE PANTHER PTHR30525 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30525 PDB 1JVS http://www.ebi.ac.uk/pdbe-srv/view/entry/1JVS PDB 1K5H http://www.ebi.ac.uk/pdbe-srv/view/entry/1K5H PDB 1ONN http://www.ebi.ac.uk/pdbe-srv/view/entry/1ONN PDB 1ONO http://www.ebi.ac.uk/pdbe-srv/view/entry/1ONO PDB 1ONP http://www.ebi.ac.uk/pdbe-srv/view/entry/1ONP PDB 1Q0H http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q0H PDB 1Q0L http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q0L PDB 1Q0Q http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q0Q PDB 1T1R http://www.ebi.ac.uk/pdbe-srv/view/entry/1T1R PDB 1T1S http://www.ebi.ac.uk/pdbe-srv/view/entry/1T1S PDB 2EGH http://www.ebi.ac.uk/pdbe-srv/view/entry/2EGH PDB 3ANL http://www.ebi.ac.uk/pdbe-srv/view/entry/3ANL PDB 3ANM http://www.ebi.ac.uk/pdbe-srv/view/entry/3ANM PDB 3ANN http://www.ebi.ac.uk/pdbe-srv/view/entry/3ANN PDB 3R0I http://www.ebi.ac.uk/pdbe-srv/view/entry/3R0I PDBsum 1JVS http://www.ebi.ac.uk/pdbsum/1JVS PDBsum 1K5H http://www.ebi.ac.uk/pdbsum/1K5H PDBsum 1ONN http://www.ebi.ac.uk/pdbsum/1ONN PDBsum 1ONO http://www.ebi.ac.uk/pdbsum/1ONO PDBsum 1ONP http://www.ebi.ac.uk/pdbsum/1ONP PDBsum 1Q0H http://www.ebi.ac.uk/pdbsum/1Q0H PDBsum 1Q0L http://www.ebi.ac.uk/pdbsum/1Q0L PDBsum 1Q0Q http://www.ebi.ac.uk/pdbsum/1Q0Q PDBsum 1T1R http://www.ebi.ac.uk/pdbsum/1T1R PDBsum 1T1S http://www.ebi.ac.uk/pdbsum/1T1S PDBsum 2EGH http://www.ebi.ac.uk/pdbsum/2EGH PDBsum 3ANL http://www.ebi.ac.uk/pdbsum/3ANL PDBsum 3ANM http://www.ebi.ac.uk/pdbsum/3ANM PDBsum 3ANN http://www.ebi.ac.uk/pdbsum/3ANN PDBsum 3R0I http://www.ebi.ac.uk/pdbsum/3R0I PSORT swissprot:DXR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DXR_ECOLI PSORT-B swissprot:DXR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DXR_ECOLI PSORT2 swissprot:DXR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DXR_ECOLI Pfam PF02670 http://pfam.xfam.org/family/PF02670 Pfam PF08436 http://pfam.xfam.org/family/PF08436 Pfam PF13288 http://pfam.xfam.org/family/PF13288 Phobius swissprot:DXR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DXR_ECOLI PhylomeDB P45568 http://phylomedb.org/?seqid=P45568 ProteinModelPortal P45568 http://www.proteinmodelportal.org/query/uniprot/P45568 PubMed 10631325 http://www.ncbi.nlm.nih.gov/pubmed/10631325 PubMed 10787409 http://www.ncbi.nlm.nih.gov/pubmed/10787409 PubMed 11741911 http://www.ncbi.nlm.nih.gov/pubmed/11741911 PubMed 11872159 http://www.ncbi.nlm.nih.gov/pubmed/11872159 PubMed 12621040 http://www.ncbi.nlm.nih.gov/pubmed/12621040 PubMed 1447125 http://www.ncbi.nlm.nih.gov/pubmed/1447125 PubMed 15339150 http://www.ncbi.nlm.nih.gov/pubmed/15339150 PubMed 15567415 http://www.ncbi.nlm.nih.gov/pubmed/15567415 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9707569 http://www.ncbi.nlm.nih.gov/pubmed/9707569 RefSeq NP_414715 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414715 RefSeq WP_000811923 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000811923 SMR P45568 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45568 STRING 511145.b0173 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0173&targetmode=cogs STRING COG0743 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0743&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 SUPFAM SSF69055 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF69055 TIGRFAMs TIGR00243 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00243 UniProtKB DXR_ECOLI http://www.uniprot.org/uniprot/DXR_ECOLI UniProtKB-AC P45568 http://www.uniprot.org/uniprot/P45568 charge swissprot:DXR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DXR_ECOLI eggNOG COG0743 http://eggnogapi.embl.de/nog_data/html/tree/COG0743 eggNOG ENOG4105CEA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CEA epestfind swissprot:DXR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DXR_ECOLI garnier swissprot:DXR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DXR_ECOLI helixturnhelix swissprot:DXR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DXR_ECOLI hmoment swissprot:DXR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DXR_ECOLI iep swissprot:DXR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DXR_ECOLI inforesidue swissprot:DXR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DXR_ECOLI octanol swissprot:DXR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DXR_ECOLI pepcoil swissprot:DXR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DXR_ECOLI pepdigest swissprot:DXR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DXR_ECOLI pepinfo swissprot:DXR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DXR_ECOLI pepnet swissprot:DXR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DXR_ECOLI pepstats swissprot:DXR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DXR_ECOLI pepwheel swissprot:DXR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DXR_ECOLI pepwindow swissprot:DXR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DXR_ECOLI sigcleave swissprot:DXR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DXR_ECOLI ## Database ID URL or Descriptions # BioGrid 4259251 12 # EcoGene EG13031 yqiC # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # IntAct Q46868 3 # InterPro IPR007475 BMFP # Organism YQIC_ECOLI Escherichia coli (strain K12) # PATRIC 32121496 VBIEscCol129921_3135 # PIR H65091 H65091 # Pfam PF04380 BMFP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQIC_ECOLI Uncharacterized protein YqiC # RefSeq NP_417514 NC_000913.3 # RefSeq WP_001295626 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA69210.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # eggNOG COG2960 LUCA # eggNOG ENOG4105W0Z Bacteria BLAST swissprot:YQIC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQIC_ECOLI BioCyc ECOL316407:JW5505-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5505-MONOMER BioCyc EcoCyc:G7582-MONOMER http://biocyc.org/getid?id=EcoCyc:G7582-MONOMER COG COG2960 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2960 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1574-6968.1998.tb13343.x http://dx.doi.org/10.1111/j.1574-6968.1998.tb13343.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2847 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2847 EcoGene EG13031 http://www.ecogene.org/geneInfo.php?eg_id=EG13031 EnsemblBacteria AAC76078 http://www.ensemblgenomes.org/id/AAC76078 EnsemblBacteria AAC76078 http://www.ensemblgenomes.org/id/AAC76078 EnsemblBacteria BAE77098 http://www.ensemblgenomes.org/id/BAE77098 EnsemblBacteria BAE77098 http://www.ensemblgenomes.org/id/BAE77098 EnsemblBacteria BAE77098 http://www.ensemblgenomes.org/id/BAE77098 EnsemblBacteria b3042 http://www.ensemblgenomes.org/id/b3042 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GeneID 947524 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947524 HOGENOM HOG000265044 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000265044&db=HOGENOM6 InParanoid Q46868 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46868 IntAct Q46868 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46868* InterPro IPR007475 http://www.ebi.ac.uk/interpro/entry/IPR007475 KEGG_Gene ecj:JW5505 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5505 KEGG_Gene eco:b3042 http://www.genome.jp/dbget-bin/www_bget?eco:b3042 KEGG_Orthology KO:K09806 http://www.genome.jp/dbget-bin/www_bget?KO:K09806 OMA HESMPQP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HESMPQP PSORT swissprot:YQIC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQIC_ECOLI PSORT-B swissprot:YQIC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQIC_ECOLI PSORT2 swissprot:YQIC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQIC_ECOLI Pfam PF04380 http://pfam.xfam.org/family/PF04380 Phobius swissprot:YQIC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQIC_ECOLI PhylomeDB Q46868 http://phylomedb.org/?seqid=Q46868 ProteinModelPortal Q46868 http://www.proteinmodelportal.org/query/uniprot/Q46868 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9868784 http://www.ncbi.nlm.nih.gov/pubmed/9868784 RefSeq NP_417514 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417514 RefSeq WP_001295626 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295626 SMR Q46868 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46868 STRING 511145.b3042 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3042&targetmode=cogs STRING COG2960 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2960&targetmode=cogs UniProtKB YQIC_ECOLI http://www.uniprot.org/uniprot/YQIC_ECOLI UniProtKB-AC Q46868 http://www.uniprot.org/uniprot/Q46868 charge swissprot:YQIC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQIC_ECOLI eggNOG COG2960 http://eggnogapi.embl.de/nog_data/html/tree/COG2960 eggNOG ENOG4105W0Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105W0Z epestfind swissprot:YQIC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQIC_ECOLI garnier swissprot:YQIC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQIC_ECOLI helixturnhelix swissprot:YQIC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQIC_ECOLI hmoment swissprot:YQIC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQIC_ECOLI iep swissprot:YQIC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQIC_ECOLI inforesidue swissprot:YQIC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQIC_ECOLI octanol swissprot:YQIC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQIC_ECOLI pepcoil swissprot:YQIC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQIC_ECOLI pepdigest swissprot:YQIC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQIC_ECOLI pepinfo swissprot:YQIC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQIC_ECOLI pepnet swissprot:YQIC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQIC_ECOLI pepstats swissprot:YQIC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQIC_ECOLI pepwheel swissprot:YQIC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQIC_ECOLI pepwindow swissprot:YQIC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQIC_ECOLI sigcleave swissprot:YQIC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQIC_ECOLI ## Database ID URL or Descriptions # AltName N-acetylglucosamine-1-phosphate uridyltransferase {ECO:0000255|HAMAP-Rule MF_01631} # AltName N-acetylglucosamine-1-phosphate uridyltransferase {ECO:0000255|HAMAP-Rule MF_01631} # BIOPHYSICOCHEMICAL PROPERTIES GLMU_ECOLI Kinetic parameters KM=0.018 mM for N-acetylglucosamine 1-phosphate {ECO 0000269|PubMed 8083170, ECO 0000269|PubMed 8555230, ECO 0000269|PubMed 9733680}; KM=0.07 mM for alpha-D-glucosamine 1-phosphate {ECO 0000269|PubMed 10428949}; KM=0.1 mM for UTP {ECO 0000269|PubMed 10428949}; KM=0.15 mM for alpha-D-glucosamine 1-phosphate {ECO 0000269|PubMed 8083170, ECO 0000269|PubMed 8555230, ECO 0000269|PubMed 9733680}; KM=0.25 mM for alpha-D-glucosamine 1-phosphate {ECO 0000269|PubMed 8083170, ECO 0000269|PubMed 8555230, ECO 0000269|PubMed 9733680}; KM=0.32 mM for acetyl-CoA {ECO 0000269|PubMed 8083170, ECO 0000269|PubMed 8555230, ECO 0000269|PubMed 9733680}; KM=0.6 mM for acetyl-CoA {ECO 0000269|PubMed 8083170, ECO 0000269|PubMed 8555230, ECO 0000269|PubMed 9733680}; KM=0.84 mM for n-propionyl-CoA {ECO 0000269|PubMed 8083170, ECO 0000269|PubMed 8555230, ECO 0000269|PubMed 9733680}; KM=1.3 mM for UDP-glucosamine {ECO 0000269|PubMed 8083170, ECO 0000269|PubMed 8555230, ECO 0000269|PubMed 9733680}; KM=2 mM for glucose-1-P {ECO 0000269|PubMed 8083170, ECO 0000269|PubMed 8555230, ECO 0000269|PubMed 9733680}; KM=3.7 mM for N-acetylgalactosamine-1-P {ECO 0000269|PubMed 8083170, ECO 0000269|PubMed 8555230, ECO 0000269|PubMed 9733680}; KM=15 mM for galactosamine-1-phosphate {ECO 0000269|PubMed 8083170, ECO 0000269|PubMed 8555230, ECO 0000269|PubMed 9733680}; # BRENDA 2.3.1.157 2026 # BRENDA 2.7.7.23 2026 # BioGrid 4262143 306 # CATALYTIC ACTIVITY GLMU_ECOLI Acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + N-acetyl-alpha-D-glucosamine 1-phosphate. {ECO 0000255|HAMAP-Rule MF_01631, ECO 0000269|PubMed 10428949, ECO 0000269|PubMed 8083170, ECO 0000269|PubMed 8555230}. # CATALYTIC ACTIVITY GLMU_ECOLI UTP + N-acetyl-alpha-D-glucosamine 1-phosphate = diphosphate + UDP-N-acetyl-alpha-D-glucosamine. {ECO 0000255|HAMAP-Rule MF_01631, ECO 0000269|PubMed 10428949, ECO 0000269|PubMed 8083170, ECO 0000269|PubMed 8555230}. # COFACTOR GLMU_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 17473010}; Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000269|PubMed 11329257}; Note=Binds 1 Mg(2+) ion per subunit (PubMed 17473010). Can also use Co(2+) ion to a lesser extent (PubMed 11329257). {ECO 0000269|PubMed 11329257, ECO 0000269|PubMed 17473010}; # ENZYME REGULATION GLMU_ECOLI Inhibited by its reaction product N- acetylglucosamine-1-phosphate and by UDP-N-acetylmuramic acid, which is one of the first precursors specific for the peptidoglycan pathway. {ECO 0000269|PubMed 21984832, ECO 0000269|PubMed 22297115, ECO 0000269|PubMed 8083170}. # EcoGene EG11198 glmU # FUNCTION GLMU_ECOLI Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain. {ECO 0000255|HAMAP-Rule MF_01631, ECO 0000269|PubMed 10428949, ECO 0000269|PubMed 21984832, ECO 0000269|PubMed 22297115, ECO 0000269|PubMed 8083170, ECO 0000269|PubMed 8555230}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0003977 UDP-N-acetylglucosamine diphosphorylase activity; IDA:EcoCyc. # GO_function GO:0019134 glucosamine-1-phosphate N-acetyltransferase activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0000902 cell morphogenesis; IEA:UniProtKB-HAMAP. # GO_process GO:0006048 UDP-N-acetylglucosamine biosynthetic process; IMP:EcoCyc. # GO_process GO:0008360 regulation of cell shape; IEA:UniProtKB-KW. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IEA:InterPro. # GO_process GO:0009245 lipid A biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0009252 peptidoglycan biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0000902 cell morphogenesis # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 3.90.550.10 -; 1. # HAMAP MF_01631 GlmU # IntAct P0ACC7 19 # InterPro IPR001451 Hexapep # InterPro IPR005882 Bifunctional_GlmU # InterPro IPR011004 Trimer_LpxA-like # InterPro IPR018357 Hexapep_transf_CS # InterPro IPR025877 MobA-like_NTP_Trfase # InterPro IPR029044 Nucleotide-diphossugar_trans # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00520 Amino sugar and nucleotide sugar metabolism # Organism GLMU_ECOLI Escherichia coli (strain K12) # PATHWAY Bacterial outer membrane biogenesis; LPS lipid A biosynthesis. {ECO:0000255|HAMAP-Rule MF_01631}. # PATHWAY Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D- glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2. {ECO 0000255|HAMAP-Rule:MF_01631}. # PATHWAY Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D- glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N- acetyl-alpha-D-glucosamine 1-phosphate: step 1/1. {ECO 0000255|HAMAP-Rule:MF_01631}. # PATRIC 32122957 VBIEscCol129921_3854 # PDB 1FWY X-ray; 2.30 A; A/B=1-331 # PDB 1FXJ X-ray; 2.25 A; A/B=1-331 # PDB 1HV9 X-ray; 2.10 A; A/B=1-456 # PDB 2OI5 X-ray; 2.25 A; A/B=1-456 # PDB 2OI6 X-ray; 2.20 A; A/B=1-456 # PDB 2OI7 X-ray; 2.54 A; A/B=1-456 # PDB 3TWD X-ray; 1.90 A; A/B=233-452 # PDB 4AA7 X-ray; 2.00 A; A/B=227-456 # PIR C65176 C65176 # PROSITE PS00101 HEXAPEP_TRANSFERASES # Pfam PF00132 Hexapep; 3 # Pfam PF12804 NTP_transf_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Bifunctional protein GlmU {ECO:0000255|HAMAP-Rule MF_01631} # RecName Bifunctional protein GlmU {ECO:0000255|HAMAP-Rule MF_01631} # RecName Glucosamine-1-phosphate N-acetyltransferase {ECO:0000255|HAMAP-Rule MF_01631} # RecName UDP-N-acetylglucosamine pyrophosphorylase {ECO:0000255|HAMAP-Rule MF_01631} # RefSeq NP_418186 NC_000913.3 # RefSeq WP_000933736 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA62081.1; Type=Frameshift; Positions=179; Note=Produces two ORFs.; Evidence={ECO:0000305}; Sequence=AAA62082.1; Type=Frameshift; Positions=179; Note=Produces two ORFs.; Evidence={ECO 0000305}; # SIMILARITY In the C-terminal section; belongs to the transferase hexapeptide repeat family. {ECO:0000255|HAMAP-Rule MF_01631, ECO:0000305}. # SIMILARITY In the N-terminal section; belongs to the N- acetylglucosamine-1-phosphate uridyltransferase family. {ECO:0000255|HAMAP-Rule MF_01631, ECO:0000305}. # SUBCELLULAR LOCATION GLMU_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_01631, ECO 0000269|PubMed 10428949}. # SUBUNIT GLMU_ECOLI Homotrimer. In vivo forms a hexameric aggregate. {ECO 0000269|PubMed 10428949, ECO 0000269|PubMed 11329257, ECO 0000269|PubMed 17473010, ECO 0000269|PubMed 21984832, ECO 0000269|PubMed 22297115}. # SUPFAM SSF51161 SSF51161 # SUPFAM SSF53448 SSF53448 # TIGRFAMs TIGR01173 glmU # UniPathway UPA00113 UER00532 # UniPathway UPA00113 UER00533 # eggNOG COG1207 LUCA # eggNOG ENOG4105CAJ Bacteria BLAST swissprot:GLMU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLMU_ECOLI BioCyc ECOL316407:JW3708-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3708-MONOMER BioCyc EcoCyc:NAG1P-URIDYLTRANS-MONOMER http://biocyc.org/getid?id=EcoCyc:NAG1P-URIDYLTRANS-MONOMER BioCyc MetaCyc:NAG1P-URIDYLTRANS-MONOMER http://biocyc.org/getid?id=MetaCyc:NAG1P-URIDYLTRANS-MONOMER COG COG1207 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1207 DIP DIP-31844N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31844N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1016/j.bmcl.2012.01.016 http://dx.doi.org/10.1016/j.bmcl.2012.01.016 DOI 10.1021/bi002503n http://dx.doi.org/10.1021/bi002503n DOI 10.1021/bi952275a http://dx.doi.org/10.1021/bi952275a DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2240799 http://dx.doi.org/10.1042/bj2240799 DOI 10.1074/jbc.M111.274068 http://dx.doi.org/10.1074/jbc.M111.274068 DOI 10.1093/emboj/18.15.4096 http://dx.doi.org/10.1093/emboj/18.15.4096 DOI 10.1110/ps.072779707 http://dx.doi.org/10.1110/ps.072779707 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.157 {ECO:0000255|HAMAP-Rule:MF_01631, ECO:0000269|PubMed:10428949, ECO:0000269|PubMed:8083170, ECO:0000269|PubMed:8555230} http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.157 {ECO:0000255|HAMAP-Rule:MF_01631, ECO:0000269|PubMed:10428949, ECO:0000269|PubMed:8083170, ECO:0000269|PubMed:8555230} EC_number EC:2.7.7.23 {ECO:0000255|HAMAP-Rule:MF_01631, ECO:0000269|PubMed:10428949, ECO:0000269|PubMed:8083170, ECO:0000269|PubMed:8555230} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.23 {ECO:0000255|HAMAP-Rule:MF_01631, ECO:0000269|PubMed:10428949, ECO:0000269|PubMed:8083170, ECO:0000269|PubMed:8555230} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X01631 http://www.ebi.ac.uk/ena/data/view/X01631 ENZYME 2.3.1.157 {ECO:0000255|HAMAP-Rule:MF_01631, ECO:0000269|PubMed:10428949, ECO:0000269|PubMed:8083170, ECO:0000269|PubMed:8555230} http://enzyme.expasy.org/EC/2.3.1.157 {ECO:0000255|HAMAP-Rule:MF_01631, ECO:0000269|PubMed:10428949, ECO:0000269|PubMed:8083170, ECO:0000269|PubMed:8555230} ENZYME 2.7.7.23 {ECO:0000255|HAMAP-Rule:MF_01631, ECO:0000269|PubMed:10428949, ECO:0000269|PubMed:8083170, ECO:0000269|PubMed:8555230} http://enzyme.expasy.org/EC/2.7.7.23 {ECO:0000255|HAMAP-Rule:MF_01631, ECO:0000269|PubMed:10428949, ECO:0000269|PubMed:8083170, ECO:0000269|PubMed:8555230} EchoBASE EB1184 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1184 EcoGene EG11198 http://www.ecogene.org/geneInfo.php?eg_id=EG11198 EnsemblBacteria AAC76753 http://www.ensemblgenomes.org/id/AAC76753 EnsemblBacteria AAC76753 http://www.ensemblgenomes.org/id/AAC76753 EnsemblBacteria BAE77558 http://www.ensemblgenomes.org/id/BAE77558 EnsemblBacteria BAE77558 http://www.ensemblgenomes.org/id/BAE77558 EnsemblBacteria BAE77558 http://www.ensemblgenomes.org/id/BAE77558 EnsemblBacteria b3730 http://www.ensemblgenomes.org/id/b3730 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0003977 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003977 GO_function GO:0019134 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019134 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0000902 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000902 GO_process GO:0006048 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006048 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GO_process GO:0009245 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009245 GO_process GO:0009252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009252 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0000902 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000902 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 3.90.550.10 http://www.cathdb.info/version/latest/superfamily/3.90.550.10 GeneID 948246 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948246 HAMAP MF_01631 http://hamap.expasy.org/unirule/MF_01631 HOGENOM HOG000283476 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000283476&db=HOGENOM6 InParanoid P0ACC7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACC7 IntAct P0ACC7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACC7* IntEnz 2.3.1.157 {ECO:0000255|HAMAP-Rule:MF_01631, ECO:0000269|PubMed:10428949, ECO:0000269|PubMed:8083170, ECO:0000269|PubMed:8555230} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.157 {ECO:0000255|HAMAP-Rule:MF_01631, ECO:0000269|PubMed:10428949, ECO:0000269|PubMed:8083170, ECO:0000269|PubMed:8555230} IntEnz 2.7.7.23 {ECO:0000255|HAMAP-Rule:MF_01631, ECO:0000269|PubMed:10428949, ECO:0000269|PubMed:8083170, ECO:0000269|PubMed:8555230} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.23 {ECO:0000255|HAMAP-Rule:MF_01631, ECO:0000269|PubMed:10428949, ECO:0000269|PubMed:8083170, ECO:0000269|PubMed:8555230} InterPro IPR001451 http://www.ebi.ac.uk/interpro/entry/IPR001451 InterPro IPR005882 http://www.ebi.ac.uk/interpro/entry/IPR005882 InterPro IPR011004 http://www.ebi.ac.uk/interpro/entry/IPR011004 InterPro IPR018357 http://www.ebi.ac.uk/interpro/entry/IPR018357 InterPro IPR025877 http://www.ebi.ac.uk/interpro/entry/IPR025877 InterPro IPR029044 http://www.ebi.ac.uk/interpro/entry/IPR029044 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3708 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3708 KEGG_Gene eco:b3730 http://www.genome.jp/dbget-bin/www_bget?eco:b3730 KEGG_Orthology KO:K04042 http://www.genome.jp/dbget-bin/www_bget?KO:K04042 KEGG_Pathway ko00520 http://www.genome.jp/kegg-bin/show_pathway?ko00520 KEGG_Reaction rn:R00416 http://www.genome.jp/dbget-bin/www_bget?rn:R00416 KEGG_Reaction rn:R05332 http://www.genome.jp/dbget-bin/www_bget?rn:R05332 MINT MINT-1252604 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1252604 OMA FAHARPK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FAHARPK PDB 1FWY http://www.ebi.ac.uk/pdbe-srv/view/entry/1FWY PDB 1FXJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1FXJ PDB 1HV9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1HV9 PDB 2OI5 http://www.ebi.ac.uk/pdbe-srv/view/entry/2OI5 PDB 2OI6 http://www.ebi.ac.uk/pdbe-srv/view/entry/2OI6 PDB 2OI7 http://www.ebi.ac.uk/pdbe-srv/view/entry/2OI7 PDB 3TWD http://www.ebi.ac.uk/pdbe-srv/view/entry/3TWD PDB 4AA7 http://www.ebi.ac.uk/pdbe-srv/view/entry/4AA7 PDBsum 1FWY http://www.ebi.ac.uk/pdbsum/1FWY PDBsum 1FXJ http://www.ebi.ac.uk/pdbsum/1FXJ PDBsum 1HV9 http://www.ebi.ac.uk/pdbsum/1HV9 PDBsum 2OI5 http://www.ebi.ac.uk/pdbsum/2OI5 PDBsum 2OI6 http://www.ebi.ac.uk/pdbsum/2OI6 PDBsum 2OI7 http://www.ebi.ac.uk/pdbsum/2OI7 PDBsum 3TWD http://www.ebi.ac.uk/pdbsum/3TWD PDBsum 4AA7 http://www.ebi.ac.uk/pdbsum/4AA7 PROSITE PS00101 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00101 PSORT swissprot:GLMU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLMU_ECOLI PSORT-B swissprot:GLMU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLMU_ECOLI PSORT2 swissprot:GLMU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLMU_ECOLI Pfam PF00132 http://pfam.xfam.org/family/PF00132 Pfam PF12804 http://pfam.xfam.org/family/PF12804 Phobius swissprot:GLMU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLMU_ECOLI PhylomeDB P0ACC7 http://phylomedb.org/?seqid=P0ACC7 ProteinModelPortal P0ACC7 http://www.proteinmodelportal.org/query/uniprot/P0ACC7 PubMed 10428949 http://www.ncbi.nlm.nih.gov/pubmed/10428949 PubMed 11329257 http://www.ncbi.nlm.nih.gov/pubmed/11329257 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17473010 http://www.ncbi.nlm.nih.gov/pubmed/17473010 PubMed 21984832 http://www.ncbi.nlm.nih.gov/pubmed/21984832 PubMed 22297115 http://www.ncbi.nlm.nih.gov/pubmed/22297115 PubMed 6395859 http://www.ncbi.nlm.nih.gov/pubmed/6395859 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 8083170 http://www.ncbi.nlm.nih.gov/pubmed/8083170 PubMed 8407787 http://www.ncbi.nlm.nih.gov/pubmed/8407787 PubMed 8555230 http://www.ncbi.nlm.nih.gov/pubmed/8555230 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9733680 http://www.ncbi.nlm.nih.gov/pubmed/9733680 RefSeq NP_418186 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418186 RefSeq WP_000933736 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000933736 SMR P0ACC7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACC7 STRING 511145.b3730 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3730&targetmode=cogs STRING COG1207 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1207&targetmode=cogs SUPFAM SSF51161 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51161 SUPFAM SSF53448 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53448 TIGRFAMs TIGR01173 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01173 UniProtKB GLMU_ECOLI http://www.uniprot.org/uniprot/GLMU_ECOLI UniProtKB-AC P0ACC7 http://www.uniprot.org/uniprot/P0ACC7 charge swissprot:GLMU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLMU_ECOLI eggNOG COG1207 http://eggnogapi.embl.de/nog_data/html/tree/COG1207 eggNOG ENOG4105CAJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CAJ epestfind swissprot:GLMU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLMU_ECOLI garnier swissprot:GLMU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLMU_ECOLI helixturnhelix swissprot:GLMU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLMU_ECOLI hmoment swissprot:GLMU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLMU_ECOLI iep swissprot:GLMU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLMU_ECOLI inforesidue swissprot:GLMU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLMU_ECOLI octanol swissprot:GLMU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLMU_ECOLI pepcoil swissprot:GLMU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLMU_ECOLI pepdigest swissprot:GLMU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLMU_ECOLI pepinfo swissprot:GLMU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLMU_ECOLI pepnet swissprot:GLMU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLMU_ECOLI pepstats swissprot:GLMU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLMU_ECOLI pepwheel swissprot:GLMU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLMU_ECOLI pepwindow swissprot:GLMU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLMU_ECOLI sigcleave swissprot:GLMU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLMU_ECOLI ## Database ID URL or Descriptions # BioGrid 4259790 217 # EcoGene EG13563 ecpC # FUNCTION ECPC_ECOLI Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition (By similarity). {ECO 0000250}. # GO_process GO:0006810 transport; IEA:UniProtKB-KW. # GOslim_process GO:0006810 transport # Gene3D 2.60.40.1120 -; 1. # INDUCTION Negatively regulated by H-NS. Positively regulated by IHF and EcpR (By similarity). {ECO 0000250}. # INTERACTION ECPC_ECOLI P76594 pka; NbExp=4; IntAct=EBI-561348, EBI-557388; # IntAct P77802 2 # InterPro IPR008969 CarboxyPept-like_regulatory # InterPro IPR014766 CarboxyPept_regulatory_dom # InterPro IPR031917 Pilus_assem_C # InterPro IPR032636 Pilus_assem_dom # MISCELLANEOUS Not expressed under classical laboratory conditions, but is functional when constitutively expressed. {ECO:0000305|PubMed 20522494}. # Organism ECPC_ECOLI Escherichia coli (strain K12) # PATRIC 32115705 VBIEscCol129921_0295 # PIR C64755 C64755 # Pfam PF15976 CooC_C # Pfam PF16967 TcfC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ECPC_ECOLI Probable outer membrane usher protein EcpC # RefSeq NP_414825 NC_000913.3 # RefSeq WP_001131096 NZ_LN832404.1 # SIMILARITY Belongs to the EcpC/MatD family. {ECO 0000305}. # SUPFAM SSF49464 SSF49464 # eggNOG ENOG4108N3D Bacteria # eggNOG ENOG4110Z57 LUCA BLAST swissprot:ECPC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ECPC_ECOLI BioCyc ECOL316407:JW0285-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0285-MONOMER BioCyc EcoCyc:G6162-MONOMER http://biocyc.org/getid?id=EcoCyc:G6162-MONOMER DIP DIP-11250N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11250N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1099/mic.0.039610-0 http://dx.doi.org/10.1099/mic.0.039610-0 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB3333 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3333 EcoGene EG13563 http://www.ecogene.org/geneInfo.php?eg_id=EG13563 EnsemblBacteria AAC73394 http://www.ensemblgenomes.org/id/AAC73394 EnsemblBacteria AAC73394 http://www.ensemblgenomes.org/id/AAC73394 EnsemblBacteria BAE76075 http://www.ensemblgenomes.org/id/BAE76075 EnsemblBacteria BAE76075 http://www.ensemblgenomes.org/id/BAE76075 EnsemblBacteria BAE76075 http://www.ensemblgenomes.org/id/BAE76075 EnsemblBacteria b0291 http://www.ensemblgenomes.org/id/b0291 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 2.60.40.1120 http://www.cathdb.info/version/latest/superfamily/2.60.40.1120 GeneID 947606 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947606 HOGENOM HOG000269481 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000269481&db=HOGENOM6 IntAct P77802 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77802* InterPro IPR008969 http://www.ebi.ac.uk/interpro/entry/IPR008969 InterPro IPR014766 http://www.ebi.ac.uk/interpro/entry/IPR014766 InterPro IPR031917 http://www.ebi.ac.uk/interpro/entry/IPR031917 InterPro IPR032636 http://www.ebi.ac.uk/interpro/entry/IPR032636 KEGG_Gene ecj:JW0285 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0285 KEGG_Gene eco:b0291 http://www.genome.jp/dbget-bin/www_bget?eco:b0291 MINT MINT-1239865 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1239865 OMA YIALDFS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YIALDFS PSORT swissprot:ECPC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ECPC_ECOLI PSORT-B swissprot:ECPC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ECPC_ECOLI PSORT2 swissprot:ECPC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ECPC_ECOLI Pfam PF15976 http://pfam.xfam.org/family/PF15976 Pfam PF16967 http://pfam.xfam.org/family/PF16967 Phobius swissprot:ECPC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ECPC_ECOLI ProteinModelPortal P77802 http://www.proteinmodelportal.org/query/uniprot/P77802 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20522494 http://www.ncbi.nlm.nih.gov/pubmed/20522494 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414825 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414825 RefSeq WP_001131096 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001131096 STRING 511145.b0291 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0291&targetmode=cogs SUPFAM SSF49464 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49464 UniProtKB ECPC_ECOLI http://www.uniprot.org/uniprot/ECPC_ECOLI UniProtKB-AC P77802 http://www.uniprot.org/uniprot/P77802 charge swissprot:ECPC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ECPC_ECOLI eggNOG ENOG4108N3D http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108N3D eggNOG ENOG4110Z57 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4110Z57 epestfind swissprot:ECPC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ECPC_ECOLI garnier swissprot:ECPC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ECPC_ECOLI helixturnhelix swissprot:ECPC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ECPC_ECOLI hmoment swissprot:ECPC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ECPC_ECOLI iep swissprot:ECPC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ECPC_ECOLI inforesidue swissprot:ECPC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ECPC_ECOLI octanol swissprot:ECPC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ECPC_ECOLI pepcoil swissprot:ECPC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ECPC_ECOLI pepdigest swissprot:ECPC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ECPC_ECOLI pepinfo swissprot:ECPC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ECPC_ECOLI pepnet swissprot:ECPC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ECPC_ECOLI pepstats swissprot:ECPC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ECPC_ECOLI pepwheel swissprot:ECPC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ECPC_ECOLI pepwindow swissprot:ECPC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ECPC_ECOLI sigcleave swissprot:ECPC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ECPC_ECOLI ## Database ID URL or Descriptions # AltName ARAE_ECOLI Arabinose transporter # BioGrid 4259474 16 # CDD cd06174 MFS # EcoGene EG10056 araE # FUNCTION ARAE_ECOLI Uptake of arabinose across the boundary membrane with the concomitant transport of protons into the cell (symport system). # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_function ARAE_ECOLI GO 0005351 sugar proton symporter activity; IBA GO_Central. # GO_function GO:0015147 L-arabinose transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0015150 fucose transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0015293 symporter activity; IMP:EcoCyc. # GO_process GO:0015756 fucose transport; IDA:EcoCyc. # GO_process GO:0042882 L-arabinose transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR003663 Sugar/inositol_transpt # InterPro IPR005828 MFS_sugar_transport-like # InterPro IPR005829 Sugar_transporter_CS # InterPro IPR020846 MFS_dom # KEGG_Brite ko02000 Transporters # Organism ARAE_ECOLI Escherichia coli (strain K12) # PATRIC 32121100 VBIEscCol129921_2939 # PIR B26430 B26430 # PRINTS PR00171 SUGRTRNSPORT # PROSITE PS00216 SUGAR_TRANSPORT_1 # PROSITE PS00217 SUGAR_TRANSPORT_2 # PROSITE PS50850 MFS # Pfam PF00083 Sugar_tr # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ARAE_ECOLI Arabinose-proton symporter # RefSeq NP_417318 NC_000913.3 # RefSeq WP_000256438 NZ_LN832404.1 # SIMILARITY Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. {ECO 0000305}. # SUBCELLULAR LOCATION ARAE_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.1 the major facilitator superfamily (mfs) # TIGRFAMs TIGR00879 SP # eggNOG ENOG4107QNK Bacteria # eggNOG ENOG410XNQK LUCA BLAST swissprot:ARAE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARAE_ECOLI BioCyc ECOL316407:JW2809-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2809-MONOMER BioCyc EcoCyc:ARAE-MONOMER http://biocyc.org/getid?id=EcoCyc:ARAE-MONOMER BioCyc MetaCyc:ARAE-MONOMER http://biocyc.org/getid?id=MetaCyc:ARAE-MONOMER COG COG0477 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0477 DOI 10.1016/0022-2836(83)90035-9 http://dx.doi.org/10.1016/0022-2836(83)90035-9 DOI 10.1038/325641a0 http://dx.doi.org/10.1038/325641a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J03732 http://www.ebi.ac.uk/ena/data/view/J03732 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 EMBL X00272 http://www.ebi.ac.uk/ena/data/view/X00272 EchoBASE EB0054 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0054 EcoGene EG10056 http://www.ecogene.org/geneInfo.php?eg_id=EG10056 EnsemblBacteria AAC75880 http://www.ensemblgenomes.org/id/AAC75880 EnsemblBacteria AAC75880 http://www.ensemblgenomes.org/id/AAC75880 EnsemblBacteria BAE76910 http://www.ensemblgenomes.org/id/BAE76910 EnsemblBacteria BAE76910 http://www.ensemblgenomes.org/id/BAE76910 EnsemblBacteria BAE76910 http://www.ensemblgenomes.org/id/BAE76910 EnsemblBacteria b2841 http://www.ensemblgenomes.org/id/b2841 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0005351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005351 GO_function GO:0015147 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015147 GO_function GO:0015150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015150 GO_function GO:0015293 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293 GO_process GO:0015756 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015756 GO_process GO:0042882 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042882 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 947341 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947341 HOGENOM HOG000202868 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000202868&db=HOGENOM6 InParanoid P0AE24 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AE24 InterPro IPR003663 http://www.ebi.ac.uk/interpro/entry/IPR003663 InterPro IPR005828 http://www.ebi.ac.uk/interpro/entry/IPR005828 InterPro IPR005829 http://www.ebi.ac.uk/interpro/entry/IPR005829 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2809 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2809 KEGG_Gene eco:b2841 http://www.genome.jp/dbget-bin/www_bget?eco:b2841 KEGG_Orthology KO:K02100 http://www.genome.jp/dbget-bin/www_bget?KO:K02100 OMA HICHFIV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HICHFIV PRINTS PR00171 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00171 PROSITE PS00216 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00216 PROSITE PS00217 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00217 PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:ARAE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARAE_ECOLI PSORT-B swissprot:ARAE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARAE_ECOLI PSORT2 swissprot:ARAE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARAE_ECOLI Pfam PF00083 http://pfam.xfam.org/family/PF00083 Phobius swissprot:ARAE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARAE_ECOLI PhylomeDB P0AE24 http://phylomedb.org/?seqid=P0AE24 ProteinModelPortal P0AE24 http://www.proteinmodelportal.org/query/uniprot/P0AE24 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2836407 http://www.ncbi.nlm.nih.gov/pubmed/2836407 PubMed 3543693 http://www.ncbi.nlm.nih.gov/pubmed/3543693 PubMed 6319708 http://www.ncbi.nlm.nih.gov/pubmed/6319708 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417318 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417318 RefSeq WP_000256438 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000256438 SMR P0AE24 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AE24 STRING 511145.b2841 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2841&targetmode=cogs STRING COG0477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0477&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.1 http://www.tcdb.org/search/result.php?tc=2.A.1.1 TIGRFAMs TIGR00879 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00879 UniProtKB ARAE_ECOLI http://www.uniprot.org/uniprot/ARAE_ECOLI UniProtKB-AC P0AE24 http://www.uniprot.org/uniprot/P0AE24 charge swissprot:ARAE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARAE_ECOLI eggNOG ENOG4107QNK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QNK eggNOG ENOG410XNQK http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNQK epestfind swissprot:ARAE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARAE_ECOLI garnier swissprot:ARAE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARAE_ECOLI helixturnhelix swissprot:ARAE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARAE_ECOLI hmoment swissprot:ARAE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARAE_ECOLI iep swissprot:ARAE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARAE_ECOLI inforesidue swissprot:ARAE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARAE_ECOLI octanol swissprot:ARAE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARAE_ECOLI pepcoil swissprot:ARAE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARAE_ECOLI pepdigest swissprot:ARAE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARAE_ECOLI pepinfo swissprot:ARAE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARAE_ECOLI pepnet swissprot:ARAE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARAE_ECOLI pepstats swissprot:ARAE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARAE_ECOLI pepwheel swissprot:ARAE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARAE_ECOLI pepwindow swissprot:ARAE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARAE_ECOLI sigcleave swissprot:ARAE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARAE_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=0.94 mM for pyruvate (at 37 degrees Celsius and pH 8.5) {ECO 0000269|PubMed:20729367}; # BioGrid 4260931 19 # CATALYTIC ACTIVITY ALAC_ECOLI L-alanine + 2-oxoglutarate = pyruvate + L- glutamate. # COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI 597326; Evidence={ECO:0000305}; # EcoGene EG14198 alaC # FUNCTION ALAC_ECOLI Involved in the biosynthesis of alanine. {ECO 0000269|PubMed 20729367, ECO 0000269|PubMed 21597182}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function ALAC_ECOLI GO 0004021 L-alanine 2-oxoglutarate aminotransferase activity; IDA EcoCyc. # GO_function GO:0008483 transaminase activity; IGI:EcoliWiki. # GO_function GO:0030170 pyridoxal phosphate binding; IEA:InterPro. # GO_process GO:0006523 alanine biosynthetic process; IGI:EcoliWiki. # GO_process GO:0019272 L-alanine biosynthetic process from pyruvate; IMP:EcoCyc. # GO_process GO:0030632 D-alanine biosynthetic process; IMP:UniProtKB. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.640.10 -; 1. # Gene3D 3.90.1150.10 -; 1. # INDUCTION ALAC_ECOLI Activated by SgrR and modestly repressed by alanine and leucine via Lrp. {ECO 0000269|PubMed 17209026, ECO 0000269|PubMed 20729367}. # IntAct P77434 8 # InterPro IPR004839 Aminotransferase_I/II # InterPro IPR015421 PyrdxlP-dep_Trfase_major_sub1 # InterPro IPR015422 PyrdxlP-dep_Trfase_major_sub2 # InterPro IPR015424 PyrdxlP-dep_Trfase # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01007 Amino acid related enzymes # Organism ALAC_ECOLI Escherichia coli (strain K12) # PATRIC 32120137 VBIEscCol129921_2477 # PIR H65011 H65011 # Pfam PF00155 Aminotran_1_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ALAC_ECOLI Glutamate-pyruvate aminotransferase AlaC # RefSeq NP_416880 NC_000913.3 # RefSeq WP_000785931 NZ_LN832404.1 # SIMILARITY Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. {ECO 0000305}. # SUBCELLULAR LOCATION ALAC_ECOLI Cytoplasm {ECO 0000250}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 20729367}. # SUPFAM SSF53383 SSF53383 # eggNOG COG0436 LUCA # eggNOG ENOG4105CHM Bacteria BLAST swissprot:ALAC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ALAC_ECOLI BioCyc ECOL316407:JW2376-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2376-MONOMER BioCyc EcoCyc:G7242-MONOMER http://biocyc.org/getid?id=EcoCyc:G7242-MONOMER BioCyc MetaCyc:G7242-MONOMER http://biocyc.org/getid?id=MetaCyc:G7242-MONOMER COG COG0436 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0436 DIP DIP-12010N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12010N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00738-10 http://dx.doi.org/10.1128/JB.00738-10 DOI 10.1128/JB.01689-06 http://dx.doi.org/10.1128/JB.01689-06 DOI 10.1271/bbb.100905 http://dx.doi.org/10.1271/bbb.100905 EC_number EC:2.6.1.2 http://www.genome.jp/dbget-bin/www_bget?EC:2.6.1.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.6.1.2 http://enzyme.expasy.org/EC/2.6.1.2 EchoBASE EB3950 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3950 EcoGene EG14198 http://www.ecogene.org/geneInfo.php?eg_id=EG14198 EnsemblBacteria AAC75438 http://www.ensemblgenomes.org/id/AAC75438 EnsemblBacteria AAC75438 http://www.ensemblgenomes.org/id/AAC75438 EnsemblBacteria BAA16249 http://www.ensemblgenomes.org/id/BAA16249 EnsemblBacteria BAA16249 http://www.ensemblgenomes.org/id/BAA16249 EnsemblBacteria BAA16249 http://www.ensemblgenomes.org/id/BAA16249 EnsemblBacteria b2379 http://www.ensemblgenomes.org/id/b2379 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004021 GO_function GO:0008483 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008483 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_process GO:0006523 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006523 GO_process GO:0019272 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019272 GO_process GO:0030632 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030632 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.640.10 http://www.cathdb.info/version/latest/superfamily/3.40.640.10 Gene3D 3.90.1150.10 http://www.cathdb.info/version/latest/superfamily/3.90.1150.10 GeneID 946850 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946850 HOGENOM HOG000223051 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000223051&db=HOGENOM6 InParanoid P77434 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77434 IntAct P77434 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77434* IntEnz 2.6.1.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.6.1.2 InterPro IPR004839 http://www.ebi.ac.uk/interpro/entry/IPR004839 InterPro IPR015421 http://www.ebi.ac.uk/interpro/entry/IPR015421 InterPro IPR015422 http://www.ebi.ac.uk/interpro/entry/IPR015422 InterPro IPR015424 http://www.ebi.ac.uk/interpro/entry/IPR015424 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Gene ecj:JW2376 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2376 KEGG_Gene eco:b2379 http://www.genome.jp/dbget-bin/www_bget?eco:b2379 KEGG_Orthology KO:K14261 http://www.genome.jp/dbget-bin/www_bget?KO:K14261 OMA IVCYPSN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IVCYPSN PSORT swissprot:ALAC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ALAC_ECOLI PSORT-B swissprot:ALAC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ALAC_ECOLI PSORT2 swissprot:ALAC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ALAC_ECOLI Pfam PF00155 http://pfam.xfam.org/family/PF00155 Phobius swissprot:ALAC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ALAC_ECOLI PhylomeDB P77434 http://phylomedb.org/?seqid=P77434 ProteinModelPortal P77434 http://www.proteinmodelportal.org/query/uniprot/P77434 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17209026 http://www.ncbi.nlm.nih.gov/pubmed/17209026 PubMed 20729367 http://www.ncbi.nlm.nih.gov/pubmed/20729367 PubMed 21597182 http://www.ncbi.nlm.nih.gov/pubmed/21597182 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416880 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416880 RefSeq WP_000785931 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000785931 SMR P77434 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77434 STRING 511145.b2379 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2379&targetmode=cogs STRING COG0436 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0436&targetmode=cogs SUPFAM SSF53383 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53383 UniProtKB ALAC_ECOLI http://www.uniprot.org/uniprot/ALAC_ECOLI UniProtKB-AC P77434 http://www.uniprot.org/uniprot/P77434 charge swissprot:ALAC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ALAC_ECOLI eggNOG COG0436 http://eggnogapi.embl.de/nog_data/html/tree/COG0436 eggNOG ENOG4105CHM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CHM epestfind swissprot:ALAC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ALAC_ECOLI garnier swissprot:ALAC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ALAC_ECOLI helixturnhelix swissprot:ALAC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ALAC_ECOLI hmoment swissprot:ALAC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ALAC_ECOLI iep swissprot:ALAC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ALAC_ECOLI inforesidue swissprot:ALAC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ALAC_ECOLI octanol swissprot:ALAC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ALAC_ECOLI pepcoil swissprot:ALAC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ALAC_ECOLI pepdigest swissprot:ALAC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ALAC_ECOLI pepinfo swissprot:ALAC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ALAC_ECOLI pepnet swissprot:ALAC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ALAC_ECOLI pepstats swissprot:ALAC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ALAC_ECOLI pepwheel swissprot:ALAC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ALAC_ECOLI pepwindow swissprot:ALAC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ALAC_ECOLI sigcleave swissprot:ALAC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ALAC_ECOLI ## Database ID URL or Descriptions # BioGrid 4259829 8 # EcoGene EG13176 yaiI # HAMAP MF_00489 UPF0178 # INTERACTION YAII_ECOLI P77390 citC; NbExp=2; IntAct=EBI-1116378, EBI-1119239; # IntAct P0A8D3 9 # InterPro IPR003791 UPF0178 # Organism YAII_ECOLI Escherichia coli (strain K12) # PATRIC 32115915 VBIEscCol129921_0399 # PIR C64767 C64767 # Pfam PF02639 DUF188 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAII_ECOLI UPF0178 protein YaiI # RefSeq NP_414921 NC_000913.3 # RefSeq WP_000158159 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA83266.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the UPF0178 family. {ECO 0000305}. # eggNOG COG1671 LUCA # eggNOG ENOG4108UPT Bacteria BLAST swissprot:YAII_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAII_ECOLI BioCyc ECOL316407:JW0378-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0378-MONOMER BioCyc EcoCyc:G6230-MONOMER http://biocyc.org/getid?id=EcoCyc:G6230-MONOMER COG COG1671 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1671 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2370427 http://dx.doi.org/10.1042/bj2370427 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U39483 http://www.ebi.ac.uk/ena/data/view/U39483 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EMBL X04064 http://www.ebi.ac.uk/ena/data/view/X04064 EchoBASE EB2968 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2968 EcoGene EG13176 http://www.ecogene.org/geneInfo.php?eg_id=EG13176 EnsemblBacteria AAC73490 http://www.ensemblgenomes.org/id/AAC73490 EnsemblBacteria AAC73490 http://www.ensemblgenomes.org/id/AAC73490 EnsemblBacteria BAE76168 http://www.ensemblgenomes.org/id/BAE76168 EnsemblBacteria BAE76168 http://www.ensemblgenomes.org/id/BAE76168 EnsemblBacteria BAE76168 http://www.ensemblgenomes.org/id/BAE76168 EnsemblBacteria b0387 http://www.ensemblgenomes.org/id/b0387 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945033 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945033 HAMAP MF_00489 http://hamap.expasy.org/unirule/MF_00489 HOGENOM HOG000007334 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000007334&db=HOGENOM6 InParanoid P0A8D3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8D3 IntAct P0A8D3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8D3* InterPro IPR003791 http://www.ebi.ac.uk/interpro/entry/IPR003791 KEGG_Gene ecj:JW0378 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0378 KEGG_Gene eco:b0387 http://www.genome.jp/dbget-bin/www_bget?eco:b0387 KEGG_Orthology KO:K09768 http://www.genome.jp/dbget-bin/www_bget?KO:K09768 OMA ACPGVIK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ACPGVIK PSORT swissprot:YAII_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAII_ECOLI PSORT-B swissprot:YAII_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAII_ECOLI PSORT2 swissprot:YAII_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAII_ECOLI Pfam PF02639 http://pfam.xfam.org/family/PF02639 Phobius swissprot:YAII_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAII_ECOLI PhylomeDB P0A8D3 http://phylomedb.org/?seqid=P0A8D3 ProteinModelPortal P0A8D3 http://www.proteinmodelportal.org/query/uniprot/P0A8D3 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3026317 http://www.ncbi.nlm.nih.gov/pubmed/3026317 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414921 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414921 RefSeq WP_000158159 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000158159 SMR P0A8D3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8D3 STRING 511145.b0387 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0387&targetmode=cogs STRING COG1671 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1671&targetmode=cogs UniProtKB YAII_ECOLI http://www.uniprot.org/uniprot/YAII_ECOLI UniProtKB-AC P0A8D3 http://www.uniprot.org/uniprot/P0A8D3 charge swissprot:YAII_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAII_ECOLI eggNOG COG1671 http://eggnogapi.embl.de/nog_data/html/tree/COG1671 eggNOG ENOG4108UPT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UPT epestfind swissprot:YAII_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAII_ECOLI garnier swissprot:YAII_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAII_ECOLI helixturnhelix swissprot:YAII_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAII_ECOLI hmoment swissprot:YAII_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAII_ECOLI iep swissprot:YAII_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAII_ECOLI inforesidue swissprot:YAII_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAII_ECOLI octanol swissprot:YAII_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAII_ECOLI pepcoil swissprot:YAII_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAII_ECOLI pepdigest swissprot:YAII_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAII_ECOLI pepinfo swissprot:YAII_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAII_ECOLI pepnet swissprot:YAII_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAII_ECOLI pepstats swissprot:YAII_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAII_ECOLI pepwheel swissprot:YAII_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAII_ECOLI pepwindow swissprot:YAII_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAII_ECOLI sigcleave swissprot:YAII_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAII_ECOLI ## Database ID URL or Descriptions # AltName DNAT_ECOLI Primosomal protein I # BioGrid 4262774 122 # EcoGene EG10244 dnaT # FUNCTION DNAT_ECOLI This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'. # GO_component GO:1990077 primosome complex; IEA:UniProtKB-KW. # GO_process GO:0006261 DNA-dependent DNA replication; IMP:EcoCyc. # GO_process GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication; IPI:EcoCyc. # GO_process GO:0006269 DNA replication, synthesis of RNA primer; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0065003 macromolecular complex assembly # HAMAP MF_01061 DnaT # INTERACTION DNAT_ECOLI Self; NbExp=2; IntAct=EBI-549621, EBI-549621; P07013 priB; NbExp=4; IntAct=EBI-549621, EBI-1125223; # IntAct P0A8J2 5 # InterPro IPR020917 Primosomal_protein_1 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko03440 Homologous recombination # Organism DNAT_ECOLI Escherichia coli (strain K12) # PATRIC 32124332 VBIEscCol129921_4509 # PDB 2RU8 NMR; -; A=89-179 # PDB 4OU6 X-ray; 1.96 A; A/B/C/D/E=84-159 # PDB 4OU7 X-ray; 2.83 A; A/B/C/D/E=84-154 # PIR S56589 RMECI # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DNAT_ECOLI Primosomal protein 1 # RefSeq NP_418782 NC_000913.3 # RefSeq WP_000098818 NZ_LN832404.1 # SIMILARITY Belongs to the DnaT family. {ECO 0000305}. # eggNOG ENOG4108PM0 Bacteria # eggNOG ENOG410ZNDQ LUCA BLAST swissprot:DNAT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DNAT_ECOLI BioCyc ECOL316407:JW4326-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4326-MONOMER BioCyc EcoCyc:EG10244-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10244-MONOMER BioCyc MetaCyc:EG10244-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10244-MONOMER DIP DIP-47957N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47957N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.83.5.1256 http://dx.doi.org/10.1073/pnas.83.5.1256 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J04030 http://www.ebi.ac.uk/ena/data/view/J04030 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB0240 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0240 EcoGene EG10244 http://www.ecogene.org/geneInfo.php?eg_id=EG10244 EnsemblBacteria AAC77318 http://www.ensemblgenomes.org/id/AAC77318 EnsemblBacteria AAC77318 http://www.ensemblgenomes.org/id/AAC77318 EnsemblBacteria BAE78352 http://www.ensemblgenomes.org/id/BAE78352 EnsemblBacteria BAE78352 http://www.ensemblgenomes.org/id/BAE78352 EnsemblBacteria BAE78352 http://www.ensemblgenomes.org/id/BAE78352 EnsemblBacteria b4362 http://www.ensemblgenomes.org/id/b4362 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:1990077 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990077 GO_process GO:0006261 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006261 GO_process GO:0006267 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006267 GO_process GO:0006269 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006269 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0065003 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0065003 GeneID 948813 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948813 HAMAP MF_01061 http://hamap.expasy.org/unirule/MF_01061 HOGENOM HOG000267810 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267810&db=HOGENOM6 IntAct P0A8J2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8J2* InterPro IPR020917 http://www.ebi.ac.uk/interpro/entry/IPR020917 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW4326 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4326 KEGG_Gene eco:b4362 http://www.genome.jp/dbget-bin/www_bget?eco:b4362 KEGG_Orthology KO:K02317 http://www.genome.jp/dbget-bin/www_bget?KO:K02317 KEGG_Pathway ko03440 http://www.genome.jp/kegg-bin/show_pathway?ko03440 MINT MINT-1256745 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1256745 OMA ASFVAYW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ASFVAYW PDB 2RU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/2RU8 PDB 4OU6 http://www.ebi.ac.uk/pdbe-srv/view/entry/4OU6 PDB 4OU7 http://www.ebi.ac.uk/pdbe-srv/view/entry/4OU7 PDBsum 2RU8 http://www.ebi.ac.uk/pdbsum/2RU8 PDBsum 4OU6 http://www.ebi.ac.uk/pdbsum/4OU6 PDBsum 4OU7 http://www.ebi.ac.uk/pdbsum/4OU7 PSORT swissprot:DNAT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DNAT_ECOLI PSORT-B swissprot:DNAT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DNAT_ECOLI PSORT2 swissprot:DNAT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DNAT_ECOLI Phobius swissprot:DNAT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DNAT_ECOLI ProteinModelPortal P0A8J2 http://www.proteinmodelportal.org/query/uniprot/P0A8J2 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2844800 http://www.ncbi.nlm.nih.gov/pubmed/2844800 PubMed 3006041 http://www.ncbi.nlm.nih.gov/pubmed/3006041 PubMed 3301836 http://www.ncbi.nlm.nih.gov/pubmed/3301836 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_418782 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418782 RefSeq WP_000098818 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000098818 SMR P0A8J2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8J2 STRING 511145.b4362 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4362&targetmode=cogs UniProtKB DNAT_ECOLI http://www.uniprot.org/uniprot/DNAT_ECOLI UniProtKB-AC P0A8J2 http://www.uniprot.org/uniprot/P0A8J2 charge swissprot:DNAT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DNAT_ECOLI eggNOG ENOG4108PM0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108PM0 eggNOG ENOG410ZNDQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZNDQ epestfind swissprot:DNAT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DNAT_ECOLI garnier swissprot:DNAT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DNAT_ECOLI helixturnhelix swissprot:DNAT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DNAT_ECOLI hmoment swissprot:DNAT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DNAT_ECOLI iep swissprot:DNAT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DNAT_ECOLI inforesidue swissprot:DNAT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DNAT_ECOLI octanol swissprot:DNAT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DNAT_ECOLI pepcoil swissprot:DNAT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DNAT_ECOLI pepdigest swissprot:DNAT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DNAT_ECOLI pepinfo swissprot:DNAT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DNAT_ECOLI pepnet swissprot:DNAT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DNAT_ECOLI pepstats swissprot:DNAT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DNAT_ECOLI pepwheel swissprot:DNAT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DNAT_ECOLI pepwindow swissprot:DNAT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DNAT_ECOLI sigcleave swissprot:DNAT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DNAT_ECOLI ## Database ID URL or Descriptions # AltName SGBU_ECOLI L-xylulose-5-phosphate 3-epimerase # BioGrid 4259345 3 # CATALYTIC ACTIVITY SGBU_ECOLI L-ribulose 5-phosphate = L-xylulose 5- phosphate. # EcoGene EG12286 sgbU # FUNCTION SGBU_ECOLI Catalyzes the isomerization of L-xylulose-5-phosphate to L-ribulose-5-phosphate (Potential). May be involved in the utilization of 2,3-diketo-L-gulonate. {ECO 0000305}. # GO_function GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses; IEA:InterPro. # GO_function GO:0034015 L-ribulose-5-phosphate 3-epimerase activity; ISS:EcoCyc. # GO_process GO:0019324 L-lyxose metabolic process; IMP:EcoCyc. # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.150 -; 1. # InterPro IPR004560 L-Ru-5P_3-Epase # InterPro IPR013022 Xyl_isomerase-like_TIM-brl # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00040 Pentose and glucuronate interconversions # Organism SGBU_ECOLI Escherichia coli (strain K12) # PATRIC 32122640 VBIEscCol129921_3697 # PIR S47803 S47803 # Pfam PF01261 AP_endonuc_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SGBU_ECOLI Putative L-ribulose-5-phosphate 3-epimerase SgbU # RefSeq NP_418039 NC_000913.3 # RefSeq WP_001350555 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18559.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the L-ribulose-5-phosphate 3-epimerase family. {ECO 0000305}. # SUPFAM SSF51658 SSF51658 # TIGRFAMs TIGR00542 hxl6Piso_put # eggNOG COG3623 LUCA # eggNOG ENOG41064BZ Bacteria BLAST swissprot:SGBU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SGBU_ECOLI BioCyc ECOL316407:JW5650-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5650-MONOMER BioCyc EcoCyc:EG12286-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12286-MONOMER COG COG3623 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3623 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.16.4625-4627.2000 http://dx.doi.org/10.1128/JB.182.16.4625-4627.2000 EC_number EC:5.1.3.22 http://www.genome.jp/dbget-bin/www_bget?EC:5.1.3.22 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 5.1.3.22 http://enzyme.expasy.org/EC/5.1.3.22 EchoBASE EB2194 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2194 EcoGene EG12286 http://www.ecogene.org/geneInfo.php?eg_id=EG12286 EnsemblBacteria AAC76606 http://www.ensemblgenomes.org/id/AAC76606 EnsemblBacteria AAC76606 http://www.ensemblgenomes.org/id/AAC76606 EnsemblBacteria BAE77711 http://www.ensemblgenomes.org/id/BAE77711 EnsemblBacteria BAE77711 http://www.ensemblgenomes.org/id/BAE77711 EnsemblBacteria BAE77711 http://www.ensemblgenomes.org/id/BAE77711 EnsemblBacteria b3582 http://www.ensemblgenomes.org/id/b3582 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016861 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016861 GO_function GO:0034015 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034015 GO_process GO:0019324 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019324 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.150 http://www.cathdb.info/version/latest/superfamily/3.20.20.150 GeneID 948100 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948100 HOGENOM HOG000126090 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126090&db=HOGENOM6 InParanoid P37679 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37679 IntEnz 5.1.3.22 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.1.3.22 InterPro IPR004560 http://www.ebi.ac.uk/interpro/entry/IPR004560 InterPro IPR013022 http://www.ebi.ac.uk/interpro/entry/IPR013022 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5650 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5650 KEGG_Gene eco:b3582 http://www.genome.jp/dbget-bin/www_bget?eco:b3582 KEGG_Orthology KO:K03082 http://www.genome.jp/dbget-bin/www_bget?KO:K03082 KEGG_Pathway ko00040 http://www.genome.jp/kegg-bin/show_pathway?ko00040 KEGG_Reaction rn:R03244 http://www.genome.jp/dbget-bin/www_bget?rn:R03244 OMA SMCLSGH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SMCLSGH PSORT swissprot:SGBU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SGBU_ECOLI PSORT-B swissprot:SGBU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SGBU_ECOLI PSORT2 swissprot:SGBU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SGBU_ECOLI Pfam PF01261 http://pfam.xfam.org/family/PF01261 Phobius swissprot:SGBU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SGBU_ECOLI PhylomeDB P37679 http://phylomedb.org/?seqid=P37679 ProteinModelPortal P37679 http://www.proteinmodelportal.org/query/uniprot/P37679 PubMed 10913097 http://www.ncbi.nlm.nih.gov/pubmed/10913097 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418039 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418039 RefSeq WP_001350555 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001350555 SMR P37679 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37679 STRING 511145.b3582 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3582&targetmode=cogs STRING COG3623 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3623&targetmode=cogs SUPFAM SSF51658 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51658 TIGRFAMs TIGR00542 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00542 UniProtKB SGBU_ECOLI http://www.uniprot.org/uniprot/SGBU_ECOLI UniProtKB-AC P37679 http://www.uniprot.org/uniprot/P37679 charge swissprot:SGBU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SGBU_ECOLI eggNOG COG3623 http://eggnogapi.embl.de/nog_data/html/tree/COG3623 eggNOG ENOG41064BZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG41064BZ epestfind swissprot:SGBU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SGBU_ECOLI garnier swissprot:SGBU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SGBU_ECOLI helixturnhelix swissprot:SGBU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SGBU_ECOLI hmoment swissprot:SGBU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SGBU_ECOLI iep swissprot:SGBU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SGBU_ECOLI inforesidue swissprot:SGBU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SGBU_ECOLI octanol swissprot:SGBU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SGBU_ECOLI pepcoil swissprot:SGBU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SGBU_ECOLI pepdigest swissprot:SGBU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SGBU_ECOLI pepinfo swissprot:SGBU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SGBU_ECOLI pepnet swissprot:SGBU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SGBU_ECOLI pepstats swissprot:SGBU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SGBU_ECOLI pepwheel swissprot:SGBU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SGBU_ECOLI pepwindow swissprot:SGBU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SGBU_ECOLI sigcleave swissprot:SGBU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SGBU_ECOLI ## Database ID URL or Descriptions # BioGrid 4263024 21 # CDD cd00127 DSPc # EcoGene EG13751 ynbD # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; ISM:EcoliWiki. # GO_function GO:0004725 protein tyrosine phosphatase activity; IEA:InterPro. # GO_function GO:0008138 protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016791 phosphatase activity # Gene3D 3.90.190.10 -; 1. # INTERACTION YNBD_ECOLI P17169 glmS; NbExp=3; IntAct=EBI-551038, EBI-551022; # IntAct P76093 2 # InterPro IPR000340 Dual-sp_phosphatase_cat-dom # InterPro IPR000387 TYR_PHOSPHATASE_dom # InterPro IPR003595 Tyr_Pase_cat # InterPro IPR016130 Tyr_Pase_AS # InterPro IPR020422 TYR_PHOSPHATASE_DUAL_dom # InterPro IPR024950 DUSP # InterPro IPR029021 Prot-tyrosine_phosphatase-like # Organism YNBD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10159 PTHR10159; 2 # PATRIC 32118108 VBIEscCol129921_1474 # PIR F64892 F64892 # PROSITE PS00383 TYR_PHOSPHATASE_1 # PROSITE PS50056 TYR_PHOSPHATASE_2 # Pfam PF00782 DSPc # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNBD_ECOLI Uncharacterized protein YnbD # RefSeq NP_415929 NC_000913.3 # SIMILARITY Belongs to the protein-tyrosine phosphatase family. {ECO 0000305}. # SMART SM00195 DSPc # SMART SM00404 PTPc_motif # SUBCELLULAR LOCATION YNBD_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # SUPFAM SSF52799 SSF52799 # eggNOG COG0671 LUCA # eggNOG COG2453 LUCA # eggNOG ENOG41077RS Bacteria BLAST swissprot:YNBD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNBD_ECOLI BioCyc ECOL316407:JW1408-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1408-MONOMER BioCyc EcoCyc:G6730-MONOMER http://biocyc.org/getid?id=EcoCyc:G6730-MONOMER DIP DIP-12745N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12745N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D85081 http://www.ebi.ac.uk/ena/data/view/D85081 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3514 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3514 EcoGene EG13751 http://www.ecogene.org/geneInfo.php?eg_id=EG13751 EnsemblBacteria AAC74493 http://www.ensemblgenomes.org/id/AAC74493 EnsemblBacteria AAC74493 http://www.ensemblgenomes.org/id/AAC74493 EnsemblBacteria BAE76432 http://www.ensemblgenomes.org/id/BAE76432 EnsemblBacteria BAE76432 http://www.ensemblgenomes.org/id/BAE76432 EnsemblBacteria BAE76432 http://www.ensemblgenomes.org/id/BAE76432 EnsemblBacteria b1411 http://www.ensemblgenomes.org/id/b1411 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0004725 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004725 GO_function GO:0008138 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008138 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 Gene3D 3.90.190.10 http://www.cathdb.info/version/latest/superfamily/3.90.190.10 GeneID 945985 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945985 HOGENOM HOG000259044 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000259044&db=HOGENOM6 InParanoid P76093 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76093 IntAct P76093 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76093* InterPro IPR000340 http://www.ebi.ac.uk/interpro/entry/IPR000340 InterPro IPR000387 http://www.ebi.ac.uk/interpro/entry/IPR000387 InterPro IPR003595 http://www.ebi.ac.uk/interpro/entry/IPR003595 InterPro IPR016130 http://www.ebi.ac.uk/interpro/entry/IPR016130 InterPro IPR020422 http://www.ebi.ac.uk/interpro/entry/IPR020422 InterPro IPR024950 http://www.ebi.ac.uk/interpro/entry/IPR024950 InterPro IPR029021 http://www.ebi.ac.uk/interpro/entry/IPR029021 KEGG_Gene ecj:JW1408 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1408 KEGG_Gene eco:b1411 http://www.genome.jp/dbget-bin/www_bget?eco:b1411 MINT MINT-1248050 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1248050 OMA QHHFIDI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QHHFIDI PANTHER PTHR10159 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10159 PROSITE PS00383 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00383 PROSITE PS50056 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50056 PSORT swissprot:YNBD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNBD_ECOLI PSORT-B swissprot:YNBD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNBD_ECOLI PSORT2 swissprot:YNBD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNBD_ECOLI Pfam PF00782 http://pfam.xfam.org/family/PF00782 Phobius swissprot:YNBD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNBD_ECOLI ProteinModelPortal P76093 http://www.proteinmodelportal.org/query/uniprot/P76093 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415929 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415929 SMART SM00195 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00195 SMART SM00404 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00404 SMR P76093 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76093 STRING 511145.b1411 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1411&targetmode=cogs SUPFAM SSF52799 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52799 UniProtKB YNBD_ECOLI http://www.uniprot.org/uniprot/YNBD_ECOLI UniProtKB-AC P76093 http://www.uniprot.org/uniprot/P76093 charge swissprot:YNBD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNBD_ECOLI eggNOG COG0671 http://eggnogapi.embl.de/nog_data/html/tree/COG0671 eggNOG COG2453 http://eggnogapi.embl.de/nog_data/html/tree/COG2453 eggNOG ENOG41077RS http://eggnogapi.embl.de/nog_data/html/tree/ENOG41077RS epestfind swissprot:YNBD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNBD_ECOLI garnier swissprot:YNBD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNBD_ECOLI helixturnhelix swissprot:YNBD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNBD_ECOLI hmoment swissprot:YNBD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNBD_ECOLI iep swissprot:YNBD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNBD_ECOLI inforesidue swissprot:YNBD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNBD_ECOLI octanol swissprot:YNBD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNBD_ECOLI pepcoil swissprot:YNBD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNBD_ECOLI pepdigest swissprot:YNBD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNBD_ECOLI pepinfo swissprot:YNBD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNBD_ECOLI pepnet swissprot:YNBD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNBD_ECOLI pepstats swissprot:YNBD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNBD_ECOLI pepwheel swissprot:YNBD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNBD_ECOLI pepwindow swissprot:YNBD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNBD_ECOLI sigcleave swissprot:YNBD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNBD_ECOLI ## Database ID URL or Descriptions # BioGrid 4260694 168 # CDD cd06174 MFS # EcoGene EG12268 yhjX # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IBA:GO_Central. # GO_function GO:0005215 transporter activity; IBA:GO_Central. # GO_process GO:0031669 cellular response to nutrient levels; IEP:EcoCyc. # GO_process GO:0034220 ion transmembrane transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0008150 biological_process # GOslim_process GO:0055085 transmembrane transport # INDUCTION Induced by the two-component regulatory system YpdA/YpdB in response to pyruvate. {ECO:0000269|PubMed 23222720}. # InterPro IPR004741 Oxa_For_antiport_fam_transptr # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # KEGG_Brite ko02000 Transporters # Organism YHJX_ECOLI Escherichia coli (strain K12) # PATRIC 32122566 VBIEscCol129921_3660 # PIR S47768 S47768 # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHJX_ECOLI Uncharacterized MFS-type transporter YhjX # RefSeq NP_418003 NC_000913.3 # RefSeq WP_000189019 NZ_LN832404.1 # SIMILARITY Belongs to the major facilitator superfamily. {ECO 0000305}. # SUBCELLULAR LOCATION YHJX_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 23222720}; Multi- pass membrane protein {ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 23222720}. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.11 the major facilitator superfamily (mfs) # TIGRFAMs TIGR00890 2A0111 # eggNOG ENOG4105FCD Bacteria # eggNOG ENOG410XQUK LUCA BLAST swissprot:YHJX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHJX_ECOLI BioCyc ECOL316407:JW3516-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3516-MONOMER BioCyc EcoCyc:YHJX-MONOMER http://biocyc.org/getid?id=EcoCyc:YHJX-MONOMER COG COG0477 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0477 DIP DIP-12395N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12395N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.02051-12 http://dx.doi.org/10.1128/JB.02051-12 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2177 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2177 EcoGene EG12268 http://www.ecogene.org/geneInfo.php?eg_id=EG12268 EnsemblBacteria AAC76571 http://www.ensemblgenomes.org/id/AAC76571 EnsemblBacteria AAC76571 http://www.ensemblgenomes.org/id/AAC76571 EnsemblBacteria BAE77748 http://www.ensemblgenomes.org/id/BAE77748 EnsemblBacteria BAE77748 http://www.ensemblgenomes.org/id/BAE77748 EnsemblBacteria BAE77748 http://www.ensemblgenomes.org/id/BAE77748 EnsemblBacteria b3547 http://www.ensemblgenomes.org/id/b3547 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_process GO:0031669 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031669 GO_process GO:0034220 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 948066 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948066 HOGENOM HOG000058263 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000058263&db=HOGENOM6 InParanoid P37662 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37662 IntAct P37662 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37662* InterPro IPR004741 http://www.ebi.ac.uk/interpro/entry/IPR004741 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3516 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3516 KEGG_Gene eco:b3547 http://www.genome.jp/dbget-bin/www_bget?eco:b3547 KEGG_Orthology KO:K08177 http://www.genome.jp/dbget-bin/www_bget?KO:K08177 MINT MINT-1232452 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1232452 OMA FMIWGAI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FMIWGAI PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:YHJX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHJX_ECOLI PSORT-B swissprot:YHJX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHJX_ECOLI PSORT2 swissprot:YHJX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHJX_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:YHJX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHJX_ECOLI PhylomeDB P37662 http://phylomedb.org/?seqid=P37662 ProteinModelPortal P37662 http://www.proteinmodelportal.org/query/uniprot/P37662 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 23222720 http://www.ncbi.nlm.nih.gov/pubmed/23222720 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418003 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418003 RefSeq WP_000189019 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000189019 STRING 511145.b3547 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3547&targetmode=cogs STRING COG0477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0477&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.11 http://www.tcdb.org/search/result.php?tc=2.A.1.11 TIGRFAMs TIGR00890 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00890 UniProtKB YHJX_ECOLI http://www.uniprot.org/uniprot/YHJX_ECOLI UniProtKB-AC P37662 http://www.uniprot.org/uniprot/P37662 charge swissprot:YHJX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHJX_ECOLI eggNOG ENOG4105FCD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FCD eggNOG ENOG410XQUK http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQUK epestfind swissprot:YHJX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHJX_ECOLI garnier swissprot:YHJX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHJX_ECOLI helixturnhelix swissprot:YHJX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHJX_ECOLI hmoment swissprot:YHJX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHJX_ECOLI iep swissprot:YHJX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHJX_ECOLI inforesidue swissprot:YHJX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHJX_ECOLI octanol swissprot:YHJX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHJX_ECOLI pepcoil swissprot:YHJX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHJX_ECOLI pepdigest swissprot:YHJX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHJX_ECOLI pepinfo swissprot:YHJX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHJX_ECOLI pepnet swissprot:YHJX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHJX_ECOLI pepstats swissprot:YHJX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHJX_ECOLI pepwheel swissprot:YHJX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHJX_ECOLI pepwindow swissprot:YHJX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHJX_ECOLI sigcleave swissprot:YHJX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHJX_ECOLI ## Database ID URL or Descriptions # BioGrid 4260384 10 # EcoGene EG11654 fliG # FUNCTION FLIG_ECOLI FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0009425 bacterial-type flagellum basal body; IEA:UniProtKB-SubCell. # GO_function GO:0003774 motor activity; IEA:InterPro. # GO_process GO:0006935 chemotaxis; IEA:UniProtKB-KW. # GO_process GO:0044780 bacterial-type flagellum assembly; IMP:EcoCyc. # GO_process GO:0071973 bacterial-type flagellum-dependent cell motility; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0040011 locomotion # GOslim_process GO:0048870 cell motility # Gene3D 1.10.220.30 -; 3. # INTERACTION FLIG_ECOLI Self; NbExp=3; IntAct=EBI-1126524, EBI-1126524; P25798 fliF; NbExp=4; IntAct=EBI-1126524, EBI-1126492; P06974 fliM; NbExp=16; IntAct=EBI-1126524, EBI-560439; P76010 ycgR; NbExp=3; IntAct=EBI-1126524, EBI-554507; # IntAct P0ABZ1 26 # InterPro IPR000090 Flg_Motor_Flig # InterPro IPR011002 FliG_a-hlx # InterPro IPR023087 Flg_Motor_Flig_C # InterPro IPR028263 FliG_N # InterPro IPR032779 FliG_M # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Pathway ko02030 Bacterial chemotaxis # KEGG_Pathway ko02040 Flagellar assembly # Organism FLIG_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30534 PTHR30534 # PATRIC 32119207 VBIEscCol129921_2018 # PIR H64957 H64957 # PIRSF PIRSF003161 FliG # PRINTS PR00954 FLGMOTORFLIG # Pfam PF01706 FliG_C # Pfam PF14841 FliG_M # Pfam PF14842 FliG_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FLIG_ECOLI Flagellar motor switch protein FliG # RefSeq NP_416449 NC_000913.3 # RefSeq WP_000067950 NZ_LN832404.1 # SIMILARITY Belongs to the FliG family. {ECO 0000305}. # SUBCELLULAR LOCATION FLIG_ECOLI Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Bacterial flagellum basal body. # SUBUNIT Forms dimers and other homooligomers. Interacts with MotA via residues in its C-terminus. Interacts with flagellar brake protein YcgR. {ECO:0000269|PubMed 20346719}. # SUPFAM SSF48029 SSF48029; 2 # TIGRFAMs TIGR00207 fliG # eggNOG COG1536 LUCA # eggNOG ENOG4105CS3 Bacteria BLAST swissprot:FLIG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLIG_ECOLI BioCyc ECOL316407:JW1923-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1923-MONOMER BioCyc EcoCyc:FLIG-FLAGELLAR-SWITCH-PROTEIN http://biocyc.org/getid?id=EcoCyc:FLIG-FLAGELLAR-SWITCH-PROTEIN COG COG1536 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1536 DIP DIP-408N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-408N DOI 10.1016/0378-1119(93)90232-R http://dx.doi.org/10.1016/0378-1119(93)90232-R DOI 10.1016/S1937-6448(08)01402-0 http://dx.doi.org/10.1016/S1937-6448(08)01402-0 DOI 10.1016/j.molcel.2010.03.001 http://dx.doi.org/10.1016/j.molcel.2010.03.001 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D89826 http://www.ebi.ac.uk/ena/data/view/D89826 EMBL L13243 http://www.ebi.ac.uk/ena/data/view/L13243 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U46011 http://www.ebi.ac.uk/ena/data/view/U46011 EchoBASE EB1607 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1607 EcoGene EG11654 http://www.ecogene.org/geneInfo.php?eg_id=EG11654 EnsemblBacteria AAC75006 http://www.ensemblgenomes.org/id/AAC75006 EnsemblBacteria AAC75006 http://www.ensemblgenomes.org/id/AAC75006 EnsemblBacteria BAA15764 http://www.ensemblgenomes.org/id/BAA15764 EnsemblBacteria BAA15764 http://www.ensemblgenomes.org/id/BAA15764 EnsemblBacteria BAA15764 http://www.ensemblgenomes.org/id/BAA15764 EnsemblBacteria b1939 http://www.ensemblgenomes.org/id/b1939 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0009425 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009425 GO_function GO:0003774 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003774 GO_process GO:0006935 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006935 GO_process GO:0044780 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044780 GO_process GO:0071973 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071973 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0040011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 Gene3D 1.10.220.30 http://www.cathdb.info/version/latest/superfamily/1.10.220.30 GeneID 946451 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946451 HOGENOM HOG000257647 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000257647&db=HOGENOM6 InParanoid P0ABZ1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABZ1 IntAct P0ABZ1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABZ1* InterPro IPR000090 http://www.ebi.ac.uk/interpro/entry/IPR000090 InterPro IPR011002 http://www.ebi.ac.uk/interpro/entry/IPR011002 InterPro IPR023087 http://www.ebi.ac.uk/interpro/entry/IPR023087 InterPro IPR028263 http://www.ebi.ac.uk/interpro/entry/IPR028263 InterPro IPR032779 http://www.ebi.ac.uk/interpro/entry/IPR032779 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW1923 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1923 KEGG_Gene eco:b1939 http://www.genome.jp/dbget-bin/www_bget?eco:b1939 KEGG_Orthology KO:K02410 http://www.genome.jp/dbget-bin/www_bget?KO:K02410 KEGG_Pathway ko02030 http://www.genome.jp/kegg-bin/show_pathway?ko02030 KEGG_Pathway ko02040 http://www.genome.jp/kegg-bin/show_pathway?ko02040 MINT MINT-8213365 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8213365 OMA RNMSKRM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RNMSKRM PANTHER PTHR30534 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30534 PRINTS PR00954 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00954 PSORT swissprot:FLIG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLIG_ECOLI PSORT-B swissprot:FLIG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLIG_ECOLI PSORT2 swissprot:FLIG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLIG_ECOLI Pfam PF01706 http://pfam.xfam.org/family/PF01706 Pfam PF14841 http://pfam.xfam.org/family/PF14841 Pfam PF14842 http://pfam.xfam.org/family/PF14842 Phobius swissprot:FLIG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLIG_ECOLI PhylomeDB P0ABZ1 http://phylomedb.org/?seqid=P0ABZ1 ProteinModelPortal P0ABZ1 http://www.proteinmodelportal.org/query/uniprot/P0ABZ1 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19081534 http://www.ncbi.nlm.nih.gov/pubmed/19081534 PubMed 20346719 http://www.ncbi.nlm.nih.gov/pubmed/20346719 PubMed 8224881 http://www.ncbi.nlm.nih.gov/pubmed/8224881 PubMed 8631704 http://www.ncbi.nlm.nih.gov/pubmed/8631704 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416449 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416449 RefSeq WP_000067950 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000067950 SMR P0ABZ1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABZ1 STRING 511145.b1939 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1939&targetmode=cogs STRING COG1536 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1536&targetmode=cogs SUPFAM SSF48029 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48029 TIGRFAMs TIGR00207 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00207 UniProtKB FLIG_ECOLI http://www.uniprot.org/uniprot/FLIG_ECOLI UniProtKB-AC P0ABZ1 http://www.uniprot.org/uniprot/P0ABZ1 charge swissprot:FLIG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLIG_ECOLI eggNOG COG1536 http://eggnogapi.embl.de/nog_data/html/tree/COG1536 eggNOG ENOG4105CS3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CS3 epestfind swissprot:FLIG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLIG_ECOLI garnier swissprot:FLIG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLIG_ECOLI helixturnhelix swissprot:FLIG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLIG_ECOLI hmoment swissprot:FLIG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLIG_ECOLI iep swissprot:FLIG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLIG_ECOLI inforesidue swissprot:FLIG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLIG_ECOLI octanol swissprot:FLIG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLIG_ECOLI pepcoil swissprot:FLIG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLIG_ECOLI pepdigest swissprot:FLIG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLIG_ECOLI pepinfo swissprot:FLIG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLIG_ECOLI pepnet swissprot:FLIG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLIG_ECOLI pepstats swissprot:FLIG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLIG_ECOLI pepwheel swissprot:FLIG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLIG_ECOLI pepwindow swissprot:FLIG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLIG_ECOLI sigcleave swissprot:FLIG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLIG_ECOLI ## Database ID URL or Descriptions # BioGrid 4260708 3 # EcoGene EG13263 ybbP # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006810 transport; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006810 transport # IntAct P77504 3 # InterPro IPR003838 ABC_permease_dom # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00258 Putative ABC transport system # KEGG_Brite ko02000 Transporters # Organism YBBP_ECOLI Escherichia coli (strain K12) # PATRIC 32116151 VBIEscCol129921_0517 # PIR G64780 G64780 # Pfam PF02687 FtsX; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBBP_ECOLI Uncharacterized ABC transporter permease YbbP # RefSeq NP_415029 NC_000913.3 # RefSeq WP_000561872 NZ_LN832404.1 # SIMILARITY Belongs to the ABC-4 integral membrane protein family. {ECO 0000305}. # SUBCELLULAR LOCATION YBBP_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # TCDB 3.A.1.122.15 the atp-binding cassette (abc) superfamily # eggNOG COG3127 LUCA # eggNOG ENOG4105CV6 Bacteria BLAST swissprot:YBBP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBBP_ECOLI BioCyc ECOL316407:JW0485-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0485-MONOMER BioCyc EcoCyc:YBBP-MONOMER http://biocyc.org/getid?id=EcoCyc:YBBP-MONOMER COG COG0577 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0577 COG COG3127 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3127 DIP DIP-11324N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11324N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EchoBASE EB3051 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3051 EcoGene EG13263 http://www.ecogene.org/geneInfo.php?eg_id=EG13263 EnsemblBacteria AAC73598 http://www.ensemblgenomes.org/id/AAC73598 EnsemblBacteria AAC73598 http://www.ensemblgenomes.org/id/AAC73598 EnsemblBacteria BAE76275 http://www.ensemblgenomes.org/id/BAE76275 EnsemblBacteria BAE76275 http://www.ensemblgenomes.org/id/BAE76275 EnsemblBacteria BAE76275 http://www.ensemblgenomes.org/id/BAE76275 EnsemblBacteria b0496 http://www.ensemblgenomes.org/id/b0496 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 945118 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945118 HOGENOM HOG000262709 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000262709&db=HOGENOM6 InParanoid P77504 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77504 IntAct P77504 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77504* InterPro IPR003838 http://www.ebi.ac.uk/interpro/entry/IPR003838 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0485 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0485 KEGG_Gene eco:b0496 http://www.genome.jp/dbget-bin/www_bget?eco:b0496 KEGG_Orthology KO:K02004 http://www.genome.jp/dbget-bin/www_bget?KO:K02004 MINT MINT-1286702 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1286702 OMA AQIQVGM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AQIQVGM PSORT swissprot:YBBP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBBP_ECOLI PSORT-B swissprot:YBBP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBBP_ECOLI PSORT2 swissprot:YBBP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBBP_ECOLI Pfam PF02687 http://pfam.xfam.org/family/PF02687 Phobius swissprot:YBBP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBBP_ECOLI PhylomeDB P77504 http://phylomedb.org/?seqid=P77504 ProteinModelPortal P77504 http://www.proteinmodelportal.org/query/uniprot/P77504 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415029 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415029 RefSeq WP_000561872 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000561872 SMR P77504 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77504 STRING 511145.b0496 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0496&targetmode=cogs STRING COG0577 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0577&targetmode=cogs STRING COG3127 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3127&targetmode=cogs TCDB 3.A.1.122.15 http://www.tcdb.org/search/result.php?tc=3.A.1.122.15 UniProtKB YBBP_ECOLI http://www.uniprot.org/uniprot/YBBP_ECOLI UniProtKB-AC P77504 http://www.uniprot.org/uniprot/P77504 charge swissprot:YBBP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBBP_ECOLI eggNOG COG3127 http://eggnogapi.embl.de/nog_data/html/tree/COG3127 eggNOG ENOG4105CV6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CV6 epestfind swissprot:YBBP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBBP_ECOLI garnier swissprot:YBBP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBBP_ECOLI helixturnhelix swissprot:YBBP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBBP_ECOLI hmoment swissprot:YBBP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBBP_ECOLI iep swissprot:YBBP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBBP_ECOLI inforesidue swissprot:YBBP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBBP_ECOLI octanol swissprot:YBBP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBBP_ECOLI pepcoil swissprot:YBBP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBBP_ECOLI pepdigest swissprot:YBBP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBBP_ECOLI pepinfo swissprot:YBBP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBBP_ECOLI pepnet swissprot:YBBP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBBP_ECOLI pepstats swissprot:YBBP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBBP_ECOLI pepwheel swissprot:YBBP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBBP_ECOLI pepwindow swissprot:YBBP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBBP_ECOLI sigcleave swissprot:YBBP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBBP_ECOLI ## Database ID URL or Descriptions # BioGrid 4261949 37 # DISRUPTION PHENOTYPE Loss of cytidine thiolation in position 32 of some tRNA species. {ECO:0000269|PubMed 14729701}. # EcoGene EG13357 ttcA # FUNCTION TTCA_ECOLI Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). {ECO 0000255|HAMAP- Rule MF_01850, ECO 0000269|PubMed 14729701}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0016783 sulfurtransferase activity; IDA:EcoCyc. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IDA:EcoCyc. # GO_process GO:0006400 tRNA modification; IMP:EcoCyc. # GO_process GO:0034227 tRNA thio-modification; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # Gene3D 3.40.50.620 -; 1. # HAMAP MF_01850 TtcA # IntAct P76055 2 # InterPro IPR011063 TilS/TtcA_N # InterPro IPR012089 2-thiocytidine_tRNA_synth_TtcA # InterPro IPR014729 Rossmann-like_a/b/a_fold # KEGG_Brite ko03016 Transfer RNA biogenesis # Organism TTCA_ECOLI Escherichia coli (strain K12) # PATRIC 32117968 VBIEscCol129921_1404 # PIR C64884 C64884 # PIRSF PIRSF004976 ATPase_YdaO # Pfam PF01171 ATP_bind_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName tRNA 2-thiocytidine biosynthesis protein TtcA {ECO:0000255|HAMAP-Rule MF_01850} # RefSeq NP_415860 NC_000913.3 # RefSeq WP_001157406 NZ_CP014272.1 # SIMILARITY Belongs to the TtcA family. {ECO:0000255|HAMAP- Rule MF_01850}. # SUBCELLULAR LOCATION TTCA_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_01850}. # eggNOG COG0037 LUCA # eggNOG ENOG4105CB3 Bacteria BLAST swissprot:TTCA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TTCA_ECOLI BioCyc ECOL316407:JW1338-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1338-MONOMER BioCyc EcoCyc:G6675-MONOMER http://biocyc.org/getid?id=EcoCyc:G6675-MONOMER BioCyc MetaCyc:G6675-MONOMER http://biocyc.org/getid?id=MetaCyc:G6675-MONOMER COG COG0037 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0037 DOI 10.1016/j.ab.2006.07.027 http://dx.doi.org/10.1016/j.ab.2006.07.027 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.186.3.750-757.2004 http://dx.doi.org/10.1128/JB.186.3.750-757.2004 DOI 10.1271/bbb.58.117 http://dx.doi.org/10.1271/bbb.58.117 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D21139 http://www.ebi.ac.uk/ena/data/view/D21139 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3140 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3140 EcoGene EG13357 http://www.ecogene.org/geneInfo.php?eg_id=EG13357 EnsemblBacteria AAC74426 http://www.ensemblgenomes.org/id/AAC74426 EnsemblBacteria AAC74426 http://www.ensemblgenomes.org/id/AAC74426 EnsemblBacteria BAE76407 http://www.ensemblgenomes.org/id/BAE76407 EnsemblBacteria BAE76407 http://www.ensemblgenomes.org/id/BAE76407 EnsemblBacteria BAE76407 http://www.ensemblgenomes.org/id/BAE76407 EnsemblBacteria b1344 http://www.ensemblgenomes.org/id/b1344 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016783 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016783 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0006400 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006400 GO_process GO:0034227 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034227 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 GeneID 948967 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948967 HAMAP MF_01850 http://hamap.expasy.org/unirule/MF_01850 HOGENOM HOG000013323 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000013323&db=HOGENOM6 InParanoid P76055 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76055 IntAct P76055 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76055* InterPro IPR011063 http://www.ebi.ac.uk/interpro/entry/IPR011063 InterPro IPR012089 http://www.ebi.ac.uk/interpro/entry/IPR012089 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW1338 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1338 KEGG_Gene eco:b1344 http://www.genome.jp/dbget-bin/www_bget?eco:b1344 KEGG_Orthology KO:K14058 http://www.genome.jp/dbget-bin/www_bget?KO:K14058 OMA NMIEEND http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NMIEEND PSORT swissprot:TTCA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TTCA_ECOLI PSORT-B swissprot:TTCA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TTCA_ECOLI PSORT2 swissprot:TTCA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TTCA_ECOLI Pfam PF01171 http://pfam.xfam.org/family/PF01171 Phobius swissprot:TTCA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TTCA_ECOLI PhylomeDB P76055 http://phylomedb.org/?seqid=P76055 ProteinModelPortal P76055 http://www.proteinmodelportal.org/query/uniprot/P76055 PubMed 14729701 http://www.ncbi.nlm.nih.gov/pubmed/14729701 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16962548 http://www.ncbi.nlm.nih.gov/pubmed/16962548 PubMed 7764507 http://www.ncbi.nlm.nih.gov/pubmed/7764507 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415860 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415860 RefSeq WP_001157406 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001157406 SMR P76055 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76055 STRING 511145.b1344 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1344&targetmode=cogs STRING COG0037 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0037&targetmode=cogs UniProtKB TTCA_ECOLI http://www.uniprot.org/uniprot/TTCA_ECOLI UniProtKB-AC P76055 http://www.uniprot.org/uniprot/P76055 charge swissprot:TTCA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TTCA_ECOLI eggNOG COG0037 http://eggnogapi.embl.de/nog_data/html/tree/COG0037 eggNOG ENOG4105CB3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CB3 epestfind swissprot:TTCA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TTCA_ECOLI garnier swissprot:TTCA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TTCA_ECOLI helixturnhelix swissprot:TTCA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TTCA_ECOLI hmoment swissprot:TTCA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TTCA_ECOLI iep swissprot:TTCA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TTCA_ECOLI inforesidue swissprot:TTCA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TTCA_ECOLI octanol swissprot:TTCA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TTCA_ECOLI pepcoil swissprot:TTCA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TTCA_ECOLI pepdigest swissprot:TTCA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TTCA_ECOLI pepinfo swissprot:TTCA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TTCA_ECOLI pepnet swissprot:TTCA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TTCA_ECOLI pepstats swissprot:TTCA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TTCA_ECOLI pepwheel swissprot:TTCA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TTCA_ECOLI pepwindow swissprot:TTCA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TTCA_ECOLI sigcleave swissprot:TTCA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TTCA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259974 3 # EcoGene EG10386 glnH # FUNCTION GLNH_ECOLI Involved in a glutamine-transport system GlnHPQ. {ECO 0000269|PubMed 3027504}. # GO_component GO:0016020 membrane; IEA:InterPro. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0004970 ionotropic glutamate receptor activity; IEA:InterPro. # GO_process GO:0006865 amino acid transport; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # INDUCTION By lack of glutamine. {ECO:0000269|PubMed 3027504}. # InterPro IPR001320 Iontro_rcpt # InterPro IPR001638 Solute-binding_3/MltF_N # InterPro IPR018313 SBP_3_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00227 Glutamine transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism GLNH_ECOLI Escherichia coli (strain K12) # PATRIC 32116825 VBIEscCol129921_0838 # PDB 1GGG X-ray; 2.30 A; A/B=23-248 # PDB 1WDN X-ray; 1.94 A; A=23-248 # PIR S03181 JKECQ # PROSITE PS01039 SBP_BACTERIAL_3 # Pfam PF00497 SBP_bac_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLNH_ECOLI Glutamine-binding periplasmic protein # RefSeq NP_415332 NC_000913.3 # RefSeq WP_000843866 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial solute-binding protein 3 family. {ECO 0000305}. # SMART SM00062 PBPb # SMART SM00079 PBPe # SUBCELLULAR LOCATION GLNH_ECOLI Periplasm {ECO 0000305|PubMed 3027504}. # TCDB 3.A.1.3 the atp-binding cassette (abc) superfamily # eggNOG COG0834 LUCA # eggNOG ENOG4107R0W Bacteria BLAST swissprot:GLNH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLNH_ECOLI BioCyc ECOL316407:JW0796-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0796-MONOMER BioCyc EcoCyc:GLNH-MONOMER http://biocyc.org/getid?id=EcoCyc:GLNH-MONOMER BioCyc MetaCyc:GLNH-MONOMER http://biocyc.org/getid?id=MetaCyc:GLNH-MONOMER COG COG0834 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0834 DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1996.0509 http://dx.doi.org/10.1006/jmbi.1996.0509 DOI 10.1006/jmbi.1998.1675 http://dx.doi.org/10.1006/jmbi.1998.1675 DOI 10.1007/BF00430437 http://dx.doi.org/10.1007/BF00430437 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X14180 http://www.ebi.ac.uk/ena/data/view/X14180 EchoBASE EB0381 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0381 EcoGene EG10386 http://www.ecogene.org/geneInfo.php?eg_id=EG10386 EnsemblBacteria AAC73898 http://www.ensemblgenomes.org/id/AAC73898 EnsemblBacteria AAC73898 http://www.ensemblgenomes.org/id/AAC73898 EnsemblBacteria BAA35483 http://www.ensemblgenomes.org/id/BAA35483 EnsemblBacteria BAA35483 http://www.ensemblgenomes.org/id/BAA35483 EnsemblBacteria BAA35483 http://www.ensemblgenomes.org/id/BAA35483 EnsemblBacteria b0811 http://www.ensemblgenomes.org/id/b0811 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0004970 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004970 GO_process GO:0006865 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 944872 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944872 HOGENOM HOG000031895 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000031895&db=HOGENOM6 InParanoid P0AEQ3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEQ3 IntAct P0AEQ3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEQ3* InterPro IPR001320 http://www.ebi.ac.uk/interpro/entry/IPR001320 InterPro IPR001638 http://www.ebi.ac.uk/interpro/entry/IPR001638 InterPro IPR018313 http://www.ebi.ac.uk/interpro/entry/IPR018313 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0796 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0796 KEGG_Gene eco:b0811 http://www.genome.jp/dbget-bin/www_bget?eco:b0811 KEGG_Orthology KO:K10036 http://www.genome.jp/dbget-bin/www_bget?KO:K10036 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA RDNGTYA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RDNGTYA PDB 1GGG http://www.ebi.ac.uk/pdbe-srv/view/entry/1GGG PDB 1WDN http://www.ebi.ac.uk/pdbe-srv/view/entry/1WDN PDBsum 1GGG http://www.ebi.ac.uk/pdbsum/1GGG PDBsum 1WDN http://www.ebi.ac.uk/pdbsum/1WDN PROSITE PS01039 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01039 PSORT swissprot:GLNH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLNH_ECOLI PSORT-B swissprot:GLNH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLNH_ECOLI PSORT2 swissprot:GLNH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLNH_ECOLI Pfam PF00497 http://pfam.xfam.org/family/PF00497 Phobius swissprot:GLNH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLNH_ECOLI PhylomeDB P0AEQ3 http://phylomedb.org/?seqid=P0AEQ3 ProteinModelPortal P0AEQ3 http://www.proteinmodelportal.org/query/uniprot/P0AEQ3 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3027504 http://www.ncbi.nlm.nih.gov/pubmed/3027504 PubMed 8831790 http://www.ncbi.nlm.nih.gov/pubmed/8831790 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9571045 http://www.ncbi.nlm.nih.gov/pubmed/9571045 RefSeq NP_415332 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415332 RefSeq WP_000843866 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000843866 SMART SM00062 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00062 SMART SM00079 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00079 SMR P0AEQ3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEQ3 STRING 511145.b0811 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0811&targetmode=cogs STRING COG0834 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0834&targetmode=cogs SWISS-2DPAGE P0AEQ3 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AEQ3 TCDB 3.A.1.3 http://www.tcdb.org/search/result.php?tc=3.A.1.3 UniProtKB GLNH_ECOLI http://www.uniprot.org/uniprot/GLNH_ECOLI UniProtKB-AC P0AEQ3 http://www.uniprot.org/uniprot/P0AEQ3 charge swissprot:GLNH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLNH_ECOLI eggNOG COG0834 http://eggnogapi.embl.de/nog_data/html/tree/COG0834 eggNOG ENOG4107R0W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107R0W epestfind swissprot:GLNH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLNH_ECOLI garnier swissprot:GLNH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLNH_ECOLI helixturnhelix swissprot:GLNH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLNH_ECOLI hmoment swissprot:GLNH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLNH_ECOLI iep swissprot:GLNH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLNH_ECOLI inforesidue swissprot:GLNH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLNH_ECOLI octanol swissprot:GLNH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLNH_ECOLI pepcoil swissprot:GLNH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLNH_ECOLI pepdigest swissprot:GLNH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLNH_ECOLI pepinfo swissprot:GLNH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLNH_ECOLI pepnet swissprot:GLNH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLNH_ECOLI pepstats swissprot:GLNH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLNH_ECOLI pepwheel swissprot:GLNH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLNH_ECOLI pepwindow swissprot:GLNH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLNH_ECOLI sigcleave swissprot:GLNH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLNH_ECOLI ## Database ID URL or Descriptions # AltName Ferric hydroxamate uptake protein B {ECO 0000305} # AltName Ferrichrome transport system permease protein FhuB {ECO 0000305} # AltName Ferrichrome uptake protein FhuB {ECO 0000305} # AltName Iron(III)-hydroxamate import system permease protein FhuB {ECO 0000305} # BioGrid 4259735 143 # DOMAIN FHUB_ECOLI FhuD interacts with a periplasmic and a transmembrane/cytoplasmic region of FhuB. The transmembrane region may be part of a pore through which a portion of FhuD inserts into the cytoplasmic membrane during transport. {ECO 0000269|PubMed 9426146}. # EcoGene EG10303 fhuB # FUNCTION FHUB_ECOLI Part of the ABC transporter complex FhuCDB involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane. {ECO 0000269|PubMed 1551849, ECO 0000269|PubMed 3020380}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005215 transporter activity; IEA:InterPro. # GO_process GO:0006811 ion transport; IEA:UniProtKB-KW. # GO_process GO:0055072 iron ion homeostasis; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006810 transport # GOslim_process GO:0042592 homeostatic process # Gene3D 1.10.3470.10 -; 2. # INDUCTION Induced 2.1-fold by hydroxyurea. {ECO:0000269|PubMed 20005847}. # InterPro IPR000522 ABC_transptr_FecCD # InterPro IPR029022 ABC_BtuC-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00240 Iron complex transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism FHUB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30472 PTHR30472 # PATRIC 32115415 VBIEscCol129921_0159 # PIR A64739 A64739 # Pfam PF01032 FecCD; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Iron(3+)-hydroxamate import system permease protein FhuB {ECO 0000305} # RefSeq NP_414695 NC_000913.3 # RefSeq WP_000044072 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA27853.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION FHUB_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255, ECO 0000269|PubMed 15919996}. # SUBUNIT FHUB_ECOLI The complex is composed of two ATP-binding proteins (FhuC), two transmembrane proteins (FhuB) and a solute-binding protein (FhuD) (Probable). FhuB interacts with FhuC and FhuD (PubMed 1551849, PubMed 8522527, PubMed 9426146). {ECO 0000269|PubMed 1551849, ECO 0000269|PubMed 8522527, ECO 0000269|PubMed 9426146, ECO 0000305}. # SUPFAM SSF81345 SSF81345; 2 # TCDB 3.A.1.14 the atp-binding cassette (abc) superfamily # eggNOG COG0609 LUCA # eggNOG ENOG4105S6R Bacteria BLAST swissprot:FHUB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FHUB_ECOLI BioCyc ECOL316407:JW0149-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0149-MONOMER BioCyc EcoCyc:FHUB-MONOMER http://biocyc.org/getid?id=EcoCyc:FHUB-MONOMER BioCyc MetaCyc:FHUB-MONOMER http://biocyc.org/getid?id=MetaCyc:FHUB-MONOMER COG COG0609 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0609 DIP DIP-9603N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9603N DOI 10.1007/BF00329835 http://dx.doi.org/10.1007/BF00329835 DOI 10.1007/BF00331021 http://dx.doi.org/10.1007/BF00331021 DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1997.6592008.x http://dx.doi.org/10.1046/j.1365-2958.1997.6592008.x DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EMBL X04319 http://www.ebi.ac.uk/ena/data/view/X04319 EMBL X04319 http://www.ebi.ac.uk/ena/data/view/X04319 EMBL X05810 http://www.ebi.ac.uk/ena/data/view/X05810 EchoBASE EB0299 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0299 EcoGene EG10303 http://www.ecogene.org/geneInfo.php?eg_id=EG10303 EnsemblBacteria AAC73264 http://www.ensemblgenomes.org/id/AAC73264 EnsemblBacteria AAC73264 http://www.ensemblgenomes.org/id/AAC73264 EnsemblBacteria BAB96729 http://www.ensemblgenomes.org/id/BAB96729 EnsemblBacteria BAB96729 http://www.ensemblgenomes.org/id/BAB96729 EnsemblBacteria BAB96729 http://www.ensemblgenomes.org/id/BAB96729 EnsemblBacteria b0153 http://www.ensemblgenomes.org/id/b0153 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_process GO:0006811 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811 GO_process GO:0055072 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055072 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 Gene3D 1.10.3470.10 http://www.cathdb.info/version/latest/superfamily/1.10.3470.10 GeneID 946890 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946890 HOGENOM HOG000260186 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260186&db=HOGENOM6 InParanoid P06972 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P06972 IntAct P06972 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P06972* InterPro IPR000522 http://www.ebi.ac.uk/interpro/entry/IPR000522 InterPro IPR029022 http://www.ebi.ac.uk/interpro/entry/IPR029022 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0149 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0149 KEGG_Gene eco:b0153 http://www.genome.jp/dbget-bin/www_bget?eco:b0153 KEGG_Orthology KO:K02015 http://www.genome.jp/dbget-bin/www_bget?KO:K02015 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 MINT MINT-1304500 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1304500 OMA WMSGSTY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WMSGSTY PANTHER PTHR30472 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30472 PSORT swissprot:FHUB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FHUB_ECOLI PSORT-B swissprot:FHUB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FHUB_ECOLI PSORT2 swissprot:FHUB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FHUB_ECOLI Pfam PF01032 http://pfam.xfam.org/family/PF01032 Phobius swissprot:FHUB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FHUB_ECOLI ProteinModelPortal P06972 http://www.proteinmodelportal.org/query/uniprot/P06972 PubMed 1551849 http://www.ncbi.nlm.nih.gov/pubmed/1551849 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 2823072 http://www.ncbi.nlm.nih.gov/pubmed/2823072 PubMed 3020380 http://www.ncbi.nlm.nih.gov/pubmed/3020380 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 8522527 http://www.ncbi.nlm.nih.gov/pubmed/8522527 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9426146 http://www.ncbi.nlm.nih.gov/pubmed/9426146 RefSeq NP_414695 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414695 RefSeq WP_000044072 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000044072 SMR P06972 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P06972 STRING 511145.b0153 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0153&targetmode=cogs STRING COG0609 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0609&targetmode=cogs SUPFAM SSF81345 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81345 TCDB 3.A.1.14 http://www.tcdb.org/search/result.php?tc=3.A.1.14 UniProtKB FHUB_ECOLI http://www.uniprot.org/uniprot/FHUB_ECOLI UniProtKB-AC P06972 http://www.uniprot.org/uniprot/P06972 charge swissprot:FHUB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FHUB_ECOLI eggNOG COG0609 http://eggnogapi.embl.de/nog_data/html/tree/COG0609 eggNOG ENOG4105S6R http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105S6R epestfind swissprot:FHUB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FHUB_ECOLI garnier swissprot:FHUB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FHUB_ECOLI helixturnhelix swissprot:FHUB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FHUB_ECOLI hmoment swissprot:FHUB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FHUB_ECOLI iep swissprot:FHUB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FHUB_ECOLI inforesidue swissprot:FHUB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FHUB_ECOLI octanol swissprot:FHUB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FHUB_ECOLI pepcoil swissprot:FHUB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FHUB_ECOLI pepdigest swissprot:FHUB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FHUB_ECOLI pepinfo swissprot:FHUB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FHUB_ECOLI pepnet swissprot:FHUB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FHUB_ECOLI pepstats swissprot:FHUB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FHUB_ECOLI pepwheel swissprot:FHUB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FHUB_ECOLI pepwindow swissprot:FHUB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FHUB_ECOLI sigcleave swissprot:FHUB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FHUB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260870 553 # CATALYTIC ACTIVITY UDP-2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)- alpha-D-glucosamine + 2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)- alpha-D-glucosaminyl 1-phosphate = UDP + 2-N,3-O-bis((3R)-3- hydroxytetradecanoyl)-beta-D-glucosaminyl-(1->6)-2-N,3-O-bis((3R)- 3-hydroxytetradecanoyl)-alpha-D-glucosaminyl 1-phosphate. {ECO:0000269|PubMed 6370995}. # CAZy GT19 Glycosyltransferase Family 19 # EcoGene EG10546 lpxB # FUNCTION LPXB_ECOLI Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. # GO_component GO:0005737 cytoplasm; IDA:EcoCyc. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0019897 extrinsic component of plasma membrane; IDA:EcoliWiki. # GO_function GO:0005543 phospholipid binding; IDA:EcoliWiki. # GO_function GO:0008915 lipid-A-disaccharide synthase activity; IDA:EcoliWiki. # GO_process GO:0009245 lipid A biosynthetic process; IMP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0008289 lipid binding # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # HAMAP MF_00392 LpxB # INTERACTION LPXB_ECOLI P0CE47 tufA; NbExp=2; IntAct=EBI-553692, EBI-301077; # IntAct P10441 25 # InterPro IPR003835 Glyco_trans_19 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01003 Glycosyltransferases # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # KEGG_Pathway ko00540 Lipopolysaccharide biosynthesis # Organism LPXB_ECOLI Escherichia coli (strain K12) # PATHWAY Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine step 5/6. # PATRIC 32115475 VBIEscCol129921_0189 # PIR F64742 SYECLA # Pfam PF02684 LpxB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LPXB_ECOLI Lipid-A-disaccharide synthase # RefSeq NP_414724 NC_000913.3 # RefSeq WP_000139654 NZ_LN832404.1 # SIMILARITY Belongs to the LpxB family. {ECO 0000305}. # TIGRFAMs TIGR00215 lpxB # UniPathway UPA00359 UER00481 # eggNOG COG0763 LUCA # eggNOG ENOG4105D0V Bacteria BLAST swissprot:LPXB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LPXB_ECOLI BioCyc ECOL316407:JW0177-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0177-MONOMER BioCyc EcoCyc:LIPIDADISACCHARIDESYNTH-MONOMER http://biocyc.org/getid?id=EcoCyc:LIPIDADISACCHARIDESYNTH-MONOMER BioCyc MetaCyc:LIPIDADISACCHARIDESYNTH-MONOMER http://biocyc.org/getid?id=MetaCyc:LIPIDADISACCHARIDESYNTH-MONOMER COG COG0763 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0763 DIP DIP-10122N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10122N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.4.1.182 {ECO:0000269|PubMed:6370995} http://www.genome.jp/dbget-bin/www_bget?EC:2.4.1.182 {ECO:0000269|PubMed:6370995} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M19334 http://www.ebi.ac.uk/ena/data/view/M19334 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 ENZYME 2.4.1.182 {ECO:0000269|PubMed:6370995} http://enzyme.expasy.org/EC/2.4.1.182 {ECO:0000269|PubMed:6370995} EchoBASE EB0541 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0541 EcoGene EG10546 http://www.ecogene.org/geneInfo.php?eg_id=EG10546 EnsemblBacteria AAC73293 http://www.ensemblgenomes.org/id/AAC73293 EnsemblBacteria AAC73293 http://www.ensemblgenomes.org/id/AAC73293 EnsemblBacteria BAA77857 http://www.ensemblgenomes.org/id/BAA77857 EnsemblBacteria BAA77857 http://www.ensemblgenomes.org/id/BAA77857 EnsemblBacteria BAA77857 http://www.ensemblgenomes.org/id/BAA77857 EnsemblBacteria b0182 http://www.ensemblgenomes.org/id/b0182 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0019897 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019897 GO_function GO:0005543 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005543 GO_function GO:0008915 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008915 GO_process GO:0009245 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009245 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0008289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 944838 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944838 HAMAP MF_00392 http://hamap.expasy.org/unirule/MF_00392 HOGENOM HOG000018003 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000018003&db=HOGENOM6 InParanoid P10441 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P10441 IntAct P10441 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P10441* IntEnz 2.4.1.182 {ECO:0000269|PubMed:6370995} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.1.182 {ECO:0000269|PubMed:6370995} InterPro IPR003835 http://www.ebi.ac.uk/interpro/entry/IPR003835 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01003 http://www.genome.jp/dbget-bin/www_bget?ko01003 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Gene ecj:JW0177 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0177 KEGG_Gene eco:b0182 http://www.genome.jp/dbget-bin/www_bget?eco:b0182 KEGG_Orthology KO:K00748 http://www.genome.jp/dbget-bin/www_bget?KO:K00748 KEGG_Pathway ko00540 http://www.genome.jp/kegg-bin/show_pathway?ko00540 KEGG_Reaction rn:R04606 http://www.genome.jp/dbget-bin/www_bget?rn:R04606 MINT MINT-1246245 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1246245 OMA TVHFVCP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TVHFVCP PSORT swissprot:LPXB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LPXB_ECOLI PSORT-B swissprot:LPXB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LPXB_ECOLI PSORT2 swissprot:LPXB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LPXB_ECOLI Pfam PF02684 http://pfam.xfam.org/family/PF02684 Phobius swissprot:LPXB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LPXB_ECOLI PhylomeDB P10441 http://phylomedb.org/?seqid=P10441 ProteinModelPortal P10441 http://www.proteinmodelportal.org/query/uniprot/P10441 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2824445 http://www.ncbi.nlm.nih.gov/pubmed/2824445 PubMed 3277952 http://www.ncbi.nlm.nih.gov/pubmed/3277952 PubMed 3316192 http://www.ncbi.nlm.nih.gov/pubmed/3316192 PubMed 6370995 http://www.ncbi.nlm.nih.gov/pubmed/6370995 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414724 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414724 RefSeq WP_000139654 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000139654 STRING 511145.b0182 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0182&targetmode=cogs STRING COG0763 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0763&targetmode=cogs TIGRFAMs TIGR00215 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00215 UniProtKB LPXB_ECOLI http://www.uniprot.org/uniprot/LPXB_ECOLI UniProtKB-AC P10441 http://www.uniprot.org/uniprot/P10441 charge swissprot:LPXB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LPXB_ECOLI eggNOG COG0763 http://eggnogapi.embl.de/nog_data/html/tree/COG0763 eggNOG ENOG4105D0V http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D0V epestfind swissprot:LPXB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LPXB_ECOLI garnier swissprot:LPXB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LPXB_ECOLI helixturnhelix swissprot:LPXB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LPXB_ECOLI hmoment swissprot:LPXB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LPXB_ECOLI iep swissprot:LPXB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LPXB_ECOLI inforesidue swissprot:LPXB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LPXB_ECOLI octanol swissprot:LPXB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LPXB_ECOLI pepcoil swissprot:LPXB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LPXB_ECOLI pepdigest swissprot:LPXB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LPXB_ECOLI pepinfo swissprot:LPXB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LPXB_ECOLI pepnet swissprot:LPXB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LPXB_ECOLI pepstats swissprot:LPXB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LPXB_ECOLI pepwheel swissprot:LPXB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LPXB_ECOLI pepwindow swissprot:LPXB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LPXB_ECOLI sigcleave swissprot:LPXB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LPXB_ECOLI ## Database ID URL or Descriptions # AltName DOSC_ECOLI Direct oxygen-sensing cyclase # BIOPHYSICOCHEMICAL PROPERTIES DOSC_ECOLI Kinetic parameters Note=The Fe(III), Fe(II)-O(2), and Fe(II)-CO complexes of DosC display DGC activity with turnover numbers of 0.066, 0.022, and 0.022 min(-1), respectively. The DGC reaction catalyzed by DosC is the rate-determining step for c-di-GMP homeostasis. Binds O(2), CO, cyanide and imidazole with a dissociation constant of 14 uM, 0.095 uM, 4.7 uM and 0.055 uM, respectively. {ECO 0000269|PubMed 21067162}; Redox potential E(0) is -17 mV.; # BRENDA 2.7.7.65 2026 # BioGrid 4262162 6 # CATALYTIC ACTIVITY DOSC_ECOLI 2 GTP = 2 diphosphate + cyclic di-3',5'- guanylate. {ECO 0000269|PubMed 19764732, ECO 0000269|PubMed 21067162}. # CDD cd01949 GGDEF # COFACTOR DOSC_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250}; Note=Binds 1 Mg(2+) ion per subunit. {ECO 0000250}; # COFACTOR Name=heme; Xref=ChEBI:CHEBI 30413; Note=Binds 1 heme group per subunit. The Fe(2+) state binds O(2) and CO while the Fe(3+) state can bind CN(-) and imidazole.; # DISRUPTION PHENOTYPE DOSC_ECOLI Disruption results in a 2.5-fold reduction in surface adhesion, a 3.5-fold reduction in biofilm formation, a large reduction in curli production, a drastic decrease in csgB expression (400-fold reduction in aerobic growth) and in an approximately 3.5-fold reduction in pgaA transcript levels in comparison with wild-type. Disruption partially suppresses the reduced motility of a yhjH disruption; concomitant disruption of dosC, yegE, yedQ and yfiN completely restores motility, suggesting these 4 genes, together with the c-di-GMP phosphodiesterase YhjH, form a network that regulates cell motility by altering levels of c-di-GMP. {ECO 0000269|PubMed 20303158, ECO 0000269|PubMed 20553324, ECO 0000269|PubMed 20576684}. # DOMAIN DOSC_ECOLI Is composed of an N-terminal sensory globin-fold domain that binds heme and oxygen, and a C-terminal GGDEF diguanylate cyclase domain. {ECO 0000269|PubMed 21067162}. # ENZYME REGULATION Activity depends on O(2)-binding and heme redox state: the Fe(III), Fe(II)-O(2), and Fe(II)-CO complexes of DosC are active forms, whereas Fe(II) and Fe(II)-NO complexes are inactive forms. {ECO 0000269|PubMed:21067162}. # EcoGene EG13793 dosC # FUNCTION DOSC_ECOLI Globin-coupled heme-based oxygen sensor protein displaying diguanylate cyclase (DGC) activity in response to oxygen availability. Thus, catalyzes the synthesis of cyclic diguanylate (c-di-GMP) via the condensation of 2 GTP molecules. Is involved in the modulation of intracellular c-di-GMP levels, in association with DosP which catalyzes the degradation of c-di-GMP (PDE activity). Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria. DosC regulates biofilm formation through the oxygen-dependent activation of the csgBAC operon, which encodes curli structural subunits, while not affecting the expression of the regulatory operon csgDEFG. DosC, but not the other DGCs in E.coli, also promotes the production of the exopolysaccharide poly-N-acetylglucosamine (PNAG) through up- regulation of the expression of the PNAG biosynthetic pgaABCD operon, independently of CsrA. # FUNCTION DOSC_ECOLI Overexpression leads to an increased level of c-di-GMP, which leads to changes in the cell surface, to abnormal cell division, increased biofilm formation and decreased swimming (the latter 2 in strain W3110). In a strain able to produce cellulose (strain TOB1, a fecal isolate) overexpression leads to an increase in cellulose production. # GO_function GO:0005525 GTP binding; IEA:UniProtKB-KW. # GO_function GO:0019825 oxygen binding; IDA:EcoCyc. # GO_function GO:0020037 heme binding; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0052621 diguanylate cyclase activity; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.490.10 -; 1. # INDUCTION DOSC_ECOLI By RpoS in the late exponential growth phase and upon entry into stationary phase. Expression is higher at 28 than 37 degrees Celsius. In rich medium DosC and YdaM are the major RpoS- dependent GGDEF-domain containing proteins in the cell, whereas in minimal medium it is the major RpoS-dependent GGDEF-domain containing protein. Highly expressed on solid medium. A member of the dosCP operon. {ECO 0000269|PubMed 19332833, ECO 0000269|PubMed 20553324}. # InterPro IPR000160 GGDEF_dom # InterPro IPR009050 Globin-like # InterPro IPR012292 Globin/Proto # InterPro IPR029787 Nucleotide_cyclase # KEGG_Brite ko01000 Enzymes # Organism DOSC_ECOLI Escherichia coli (strain K12) # PATHWAY DOSC_ECOLI Purine metabolism; 3',5'-cyclic di-GMP biosynthesis. # PATRIC 32118274 VBIEscCol129921_1557 # PDB 4ZVA X-ray; 2.00 A; A/B=8-170 # PDB 4ZVB X-ray; 2.40 A; A/B/C/D=1-155 # PDB 4ZVC X-ray; 1.50 A; A/B=173-298 # PDB 4ZVD X-ray; 1.90 A; A/B=173-298 # PDB 4ZVE X-ray; 1.20 A; A=297-460 # PDB 4ZVF X-ray; 1.15 A; A=297-460 # PDB 4ZVG X-ray; 2.20 A; A/B=297-460 # PDB 4ZVH X-ray; 3.30 A; A/B=297-460 # PIR E64902 E64902 # PROSITE PS50887 GGDEF # Pfam PF00990 GGDEF # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DOSC_ECOLI Diguanylate cyclase DosC # RefSeq NP_416007 NC_000913.3 # RefSeq WP_000426292 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA15155.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Contains 1 GGDEF domain. {ECO:0000255|PROSITE- ProRule PRU00095}. # SMART SM00267 GGDEF # SUBUNIT DOSC_ECOLI Forms a complex with DosP. # SUPFAM SSF46458 SSF46458 # SUPFAM SSF55073 SSF55073 # TIGRFAMs TIGR00254 GGDEF # eggNOG ENOG4105BZU Bacteria # eggNOG ENOG410XNMH LUCA BLAST swissprot:DOSC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DOSC_ECOLI BioCyc ECOL316407:JW5241-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5241-MONOMER BioCyc EcoCyc:G6784-MONOMER http://biocyc.org/getid?id=EcoCyc:G6784-MONOMER BioCyc MetaCyc:G6784-MONOMER http://biocyc.org/getid?id=MetaCyc:G6784-MONOMER DOI 10.1016/j.cell.2010.01.018 http://dx.doi.org/10.1016/j.cell.2010.01.018 DOI 10.1016/j.jinorgbio.2011.09.019 http://dx.doi.org/10.1016/j.jinorgbio.2011.09.019 DOI 10.1021/bi100733q http://dx.doi.org/10.1021/bi100733q DOI 10.1021/bi901409g http://dx.doi.org/10.1021/bi901409g DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M510701200 http://dx.doi.org/10.1074/jbc.M510701200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1099/mic.0.024257-0 http://dx.doi.org/10.1099/mic.0.024257-0 DOI 10.1099/mic.0.041350-0 http://dx.doi.org/10.1099/mic.0.041350-0 DOI 10.1111/j.1365-2958.2006.05440.x http://dx.doi.org/10.1111/j.1365-2958.2006.05440.x DOI 10.1111/j.1574-695X.2010.00702.x http://dx.doi.org/10.1111/j.1574-695X.2010.00702.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.7.65 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.65 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.7.65 http://enzyme.expasy.org/EC/2.7.7.65 EchoBASE EB3554 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3554 EcoGene EG13793 http://www.ecogene.org/geneInfo.php?eg_id=EG13793 EnsemblBacteria AAC74563 http://www.ensemblgenomes.org/id/AAC74563 EnsemblBacteria AAC74563 http://www.ensemblgenomes.org/id/AAC74563 EnsemblBacteria BAA15155 http://www.ensemblgenomes.org/id/BAA15155 EnsemblBacteria BAA15155 http://www.ensemblgenomes.org/id/BAA15155 EnsemblBacteria BAA15155 http://www.ensemblgenomes.org/id/BAA15155 EnsemblBacteria b1490 http://www.ensemblgenomes.org/id/b1490 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_function GO:0019825 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019825 GO_function GO:0020037 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0020037 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0052621 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052621 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.490.10 http://www.cathdb.info/version/latest/superfamily/1.10.490.10 GeneID 945835 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945835 HOGENOM HOG000006777 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006777&db=HOGENOM6 InParanoid P0AA89 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AA89 IntEnz 2.7.7.65 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.65 InterPro IPR000160 http://www.ebi.ac.uk/interpro/entry/IPR000160 InterPro IPR009050 http://www.ebi.ac.uk/interpro/entry/IPR009050 InterPro IPR012292 http://www.ebi.ac.uk/interpro/entry/IPR012292 InterPro IPR029787 http://www.ebi.ac.uk/interpro/entry/IPR029787 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5241 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5241 KEGG_Gene eco:b1490 http://www.genome.jp/dbget-bin/www_bget?eco:b1490 KEGG_Orthology KO:K13069 http://www.genome.jp/dbget-bin/www_bget?KO:K13069 KEGG_Reaction rn:R08057 http://www.genome.jp/dbget-bin/www_bget?rn:R08057 OMA DGHPDYE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DGHPDYE PDB 4ZVA http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZVA PDB 4ZVB http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZVB PDB 4ZVC http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZVC PDB 4ZVD http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZVD PDB 4ZVE http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZVE PDB 4ZVF http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZVF PDB 4ZVG http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZVG PDB 4ZVH http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZVH PDBsum 4ZVA http://www.ebi.ac.uk/pdbsum/4ZVA PDBsum 4ZVB http://www.ebi.ac.uk/pdbsum/4ZVB PDBsum 4ZVC http://www.ebi.ac.uk/pdbsum/4ZVC PDBsum 4ZVD http://www.ebi.ac.uk/pdbsum/4ZVD PDBsum 4ZVE http://www.ebi.ac.uk/pdbsum/4ZVE PDBsum 4ZVF http://www.ebi.ac.uk/pdbsum/4ZVF PDBsum 4ZVG http://www.ebi.ac.uk/pdbsum/4ZVG PDBsum 4ZVH http://www.ebi.ac.uk/pdbsum/4ZVH PROSITE PS50887 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50887 PSORT swissprot:DOSC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DOSC_ECOLI PSORT-B swissprot:DOSC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DOSC_ECOLI PSORT2 swissprot:DOSC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DOSC_ECOLI Pfam PF00990 http://pfam.xfam.org/family/PF00990 Phobius swissprot:DOSC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DOSC_ECOLI ProteinModelPortal P0AA89 http://www.proteinmodelportal.org/query/uniprot/P0AA89 PubMed 16418169 http://www.ncbi.nlm.nih.gov/pubmed/16418169 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17010156 http://www.ncbi.nlm.nih.gov/pubmed/17010156 PubMed 19332833 http://www.ncbi.nlm.nih.gov/pubmed/19332833 PubMed 19764732 http://www.ncbi.nlm.nih.gov/pubmed/19764732 PubMed 20303158 http://www.ncbi.nlm.nih.gov/pubmed/20303158 PubMed 20553324 http://www.ncbi.nlm.nih.gov/pubmed/20553324 PubMed 20576684 http://www.ncbi.nlm.nih.gov/pubmed/20576684 PubMed 21067162 http://www.ncbi.nlm.nih.gov/pubmed/21067162 PubMed 22005448 http://www.ncbi.nlm.nih.gov/pubmed/22005448 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416007 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416007 RefSeq WP_000426292 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000426292 SMART SM00267 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00267 SMR P0AA89 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AA89 STRING 511145.b1490 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1490&targetmode=cogs SUPFAM SSF46458 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46458 SUPFAM SSF55073 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55073 TIGRFAMs TIGR00254 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00254 UniProtKB DOSC_ECOLI http://www.uniprot.org/uniprot/DOSC_ECOLI UniProtKB-AC P0AA89 http://www.uniprot.org/uniprot/P0AA89 charge swissprot:DOSC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DOSC_ECOLI eggNOG ENOG4105BZU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZU eggNOG ENOG410XNMH http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNMH epestfind swissprot:DOSC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DOSC_ECOLI garnier swissprot:DOSC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DOSC_ECOLI helixturnhelix swissprot:DOSC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DOSC_ECOLI hmoment swissprot:DOSC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DOSC_ECOLI iep swissprot:DOSC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DOSC_ECOLI inforesidue swissprot:DOSC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DOSC_ECOLI octanol swissprot:DOSC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DOSC_ECOLI pepcoil swissprot:DOSC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DOSC_ECOLI pepdigest swissprot:DOSC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DOSC_ECOLI pepinfo swissprot:DOSC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DOSC_ECOLI pepnet swissprot:DOSC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DOSC_ECOLI pepstats swissprot:DOSC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DOSC_ECOLI pepwheel swissprot:DOSC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DOSC_ECOLI pepwindow swissprot:DOSC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DOSC_ECOLI sigcleave swissprot:DOSC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DOSC_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES ACCA_ECOLI Kinetic parameters KM=100 uM for malonyl-CoA {ECO 0000269|PubMed 15066985}; KM=10 mM for biocytin {ECO 0000269|PubMed 15066985}; # BioGrid 4259753 211 # CATALYTIC ACTIVITY ACCA_ECOLI ATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoA. {ECO 0000255|HAMAP-Rule MF_00823, ECO 0000269|PubMed 15066985}. # ENZYME REGULATION Competitively inhibited by pyrrolidine dione antibiotic moiramide B (CPD1). {ECO:0000269|PubMed 15066985}. # EcoGene EG11647 accA # FUNCTION ACCA_ECOLI Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. {ECO 0000255|HAMAP-Rule MF_00823, ECO 0000269|PubMed 15066985}. # GO_component GO:0005737 cytoplasm; IC:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0009329 acetate CoA-transferase complex; IDA:EcoCyc. # GO_function GO:0003989 acetyl-CoA carboxylase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0006633 fatty acid biosynthetic process; IMP:EcoCyc. # GO_process GO:0042759 long-chain fatty acid biosynthetic process; NAS:EcoliWiki. # GO_process GO:2001295 malonyl-CoA biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.90.226.10 -; 1. # HAMAP MF_00823 AcetylCoA_CT_alpha # INTERACTION ACCA_ECOLI Self; NbExp=2; IntAct=EBI-542031, EBI-542031; P0A9Q5 accD; NbExp=14; IntAct=EBI-542031, EBI-542064; # IntAct P0ABD5 31 # InterPro IPR001095 Acetyl_CoA_COase_a_su # InterPro IPR011763 COA_CT_C # InterPro IPR029045 ClpP/crotonase-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00061 Fatty acid biosynthesis # KEGG_Pathway ko00253 Tetracycline biosynthesis # KEGG_Pathway ko00620 Pyruvate metabolism # KEGG_Pathway ko00640 Propanoate metabolism # KEGG_Pathway ko00720 Carbon fixation pathways in prokaryotes # Organism ACCA_ECOLI Escherichia coli (strain K12) # PATHWAY Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. {ECO 0000255|HAMAP-Rule:MF_00823}. # PATRIC 32115481 VBIEscCol129921_0192 # PDB 2F9Y X-ray; 3.20 A; A=1-319 # PIR A43452 A43452 # PRINTS PR01069 ACCCTRFRASEA # PROSITE PS50989 COA_CT_CTER # Pfam PF03255 ACCA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha {ECO:0000255|HAMAP-Rule MF_00823} # RefSeq NP_414727 NC_000913.3 # RefSeq WP_000055741 NZ_LN832404.1 # SIMILARITY Belongs to the AccA family. {ECO:0000255|HAMAP- Rule MF_00823}. # SIMILARITY Contains 1 CoA carboxyltransferase C-terminal domain. {ECO:0000255|PROSITE-ProRule PRU01137}. # SUBCELLULAR LOCATION ACCA_ECOLI Cytoplasm. # SUBUNIT ACCA_ECOLI Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). # SUPFAM SSF52096 SSF52096 # TIGRFAMs TIGR00513 accA # UniPathway UPA00655 UER00711 # eggNOG COG0825 LUCA # eggNOG ENOG4107QM9 Bacteria BLAST swissprot:ACCA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ACCA_ECOLI BioCyc ECOL316407:JW0180-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0180-MONOMER BioCyc EcoCyc:CARBOXYL-TRANSFERASE-ALPHA-MONOMER http://biocyc.org/getid?id=EcoCyc:CARBOXYL-TRANSFERASE-ALPHA-MONOMER BioCyc MetaCyc:CARBOXYL-TRANSFERASE-ALPHA-MONOMER http://biocyc.org/getid?id=MetaCyc:CARBOXYL-TRANSFERASE-ALPHA-MONOMER COG COG0825 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0825 DIP DIP-35897N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35897N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1021/bi0520479 http://dx.doi.org/10.1021/bi0520479 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M402989200 http://dx.doi.org/10.1074/jbc.M402989200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1266/ggs.72.167 http://dx.doi.org/10.1266/ggs.72.167 EC_number EC:6.4.1.2 {ECO:0000255|HAMAP-Rule:MF_00823} http://www.genome.jp/dbget-bin/www_bget?EC:6.4.1.2 {ECO:0000255|HAMAP-Rule:MF_00823} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D49445 http://www.ebi.ac.uk/ena/data/view/D49445 EMBL D87518 http://www.ebi.ac.uk/ena/data/view/D87518 EMBL M19334 http://www.ebi.ac.uk/ena/data/view/M19334 EMBL M96394 http://www.ebi.ac.uk/ena/data/view/M96394 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 ENZYME 6.4.1.2 {ECO:0000255|HAMAP-Rule:MF_00823} http://enzyme.expasy.org/EC/6.4.1.2 {ECO:0000255|HAMAP-Rule:MF_00823} EchoBASE EB1600 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1600 EcoGene EG11647 http://www.ecogene.org/geneInfo.php?eg_id=EG11647 EnsemblBacteria AAC73296 http://www.ensemblgenomes.org/id/AAC73296 EnsemblBacteria AAC73296 http://www.ensemblgenomes.org/id/AAC73296 EnsemblBacteria BAA77860 http://www.ensemblgenomes.org/id/BAA77860 EnsemblBacteria BAA77860 http://www.ensemblgenomes.org/id/BAA77860 EnsemblBacteria BAA77860 http://www.ensemblgenomes.org/id/BAA77860 EnsemblBacteria b0185 http://www.ensemblgenomes.org/id/b0185 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0009329 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009329 GO_function GO:0003989 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003989 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006633 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006633 GO_process GO:0042759 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042759 GO_process GO:2001295 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2001295 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.90.226.10 http://www.cathdb.info/version/latest/superfamily/3.90.226.10 GeneID 944895 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944895 HAMAP MF_00823 http://hamap.expasy.org/unirule/MF_00823 HOGENOM HOG000273832 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000273832&db=HOGENOM6 InParanoid P0ABD5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABD5 IntAct P0ABD5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABD5* IntEnz 6.4.1.2 {ECO:0000255|HAMAP-Rule:MF_00823} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.4.1.2 {ECO:0000255|HAMAP-Rule:MF_00823} InterPro IPR001095 http://www.ebi.ac.uk/interpro/entry/IPR001095 InterPro IPR011763 http://www.ebi.ac.uk/interpro/entry/IPR011763 InterPro IPR029045 http://www.ebi.ac.uk/interpro/entry/IPR029045 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0180 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0180 KEGG_Gene eco:b0185 http://www.genome.jp/dbget-bin/www_bget?eco:b0185 KEGG_Orthology KO:K01962 http://www.genome.jp/dbget-bin/www_bget?KO:K01962 KEGG_Pathway ko00061 http://www.genome.jp/kegg-bin/show_pathway?ko00061 KEGG_Pathway ko00253 http://www.genome.jp/kegg-bin/show_pathway?ko00253 KEGG_Pathway ko00620 http://www.genome.jp/kegg-bin/show_pathway?ko00620 KEGG_Pathway ko00640 http://www.genome.jp/kegg-bin/show_pathway?ko00640 KEGG_Pathway ko00720 http://www.genome.jp/kegg-bin/show_pathway?ko00720 KEGG_Reaction rn:R00742 http://www.genome.jp/dbget-bin/www_bget?rn:R00742 KEGG_Reaction rn:R04386 http://www.genome.jp/dbget-bin/www_bget?rn:R04386 MINT MINT-1228651 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1228651 OMA HSVYTVA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HSVYTVA PDB 2F9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/2F9Y PDBsum 2F9Y http://www.ebi.ac.uk/pdbsum/2F9Y PRINTS PR01069 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01069 PROSITE PS50989 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50989 PSORT swissprot:ACCA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ACCA_ECOLI PSORT-B swissprot:ACCA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ACCA_ECOLI PSORT2 swissprot:ACCA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ACCA_ECOLI Pfam PF03255 http://pfam.xfam.org/family/PF03255 Phobius swissprot:ACCA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ACCA_ECOLI PhylomeDB P0ABD5 http://phylomedb.org/?seqid=P0ABD5 ProteinModelPortal P0ABD5 http://www.proteinmodelportal.org/query/uniprot/P0ABD5 PubMed 1355089 http://www.ncbi.nlm.nih.gov/pubmed/1355089 PubMed 15066985 http://www.ncbi.nlm.nih.gov/pubmed/15066985 PubMed 16460018 http://www.ncbi.nlm.nih.gov/pubmed/16460018 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3316192 http://www.ncbi.nlm.nih.gov/pubmed/3316192 PubMed 9226257 http://www.ncbi.nlm.nih.gov/pubmed/9226257 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9339543 http://www.ncbi.nlm.nih.gov/pubmed/9339543 RefSeq NP_414727 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414727 RefSeq WP_000055741 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000055741 SMR P0ABD5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABD5 STRING 511145.b0185 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0185&targetmode=cogs STRING COG0825 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0825&targetmode=cogs SUPFAM SSF52096 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52096 TIGRFAMs TIGR00513 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00513 UniProtKB ACCA_ECOLI http://www.uniprot.org/uniprot/ACCA_ECOLI UniProtKB-AC P0ABD5 http://www.uniprot.org/uniprot/P0ABD5 charge swissprot:ACCA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ACCA_ECOLI eggNOG COG0825 http://eggnogapi.embl.de/nog_data/html/tree/COG0825 eggNOG ENOG4107QM9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QM9 epestfind swissprot:ACCA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ACCA_ECOLI garnier swissprot:ACCA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ACCA_ECOLI helixturnhelix swissprot:ACCA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ACCA_ECOLI hmoment swissprot:ACCA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ACCA_ECOLI iep swissprot:ACCA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ACCA_ECOLI inforesidue swissprot:ACCA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ACCA_ECOLI octanol swissprot:ACCA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ACCA_ECOLI pepcoil swissprot:ACCA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ACCA_ECOLI pepdigest swissprot:ACCA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ACCA_ECOLI pepinfo swissprot:ACCA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ACCA_ECOLI pepnet swissprot:ACCA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ACCA_ECOLI pepstats swissprot:ACCA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ACCA_ECOLI pepwheel swissprot:ACCA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ACCA_ECOLI pepwindow swissprot:ACCA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ACCA_ECOLI sigcleave swissprot:ACCA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ACCA_ECOLI ## Database ID URL or Descriptions # AltName DICA_ECOLI Repressor protein of division inhibition gene dicA # EcoGene EG10226 dicA # FUNCTION DICA_ECOLI This protein is a repressor of division inhibition gene dicB. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0043565 sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0007049 cell cycle; IEA:UniProtKB-KW. # GO_process GO:0051301 cell division; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0007049 cell cycle # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0051301 cell division # Gene3D 1.10.260.40 -; 1. # IntAct P06966 5 # InterPro IPR001387 Cro/C1-type_HTH # InterPro IPR010982 Lambda_DNA-bd_dom # Organism DICA_ECOLI Escherichia coli (strain K12) # PIR S05260 BVECDA # PROSITE PS50943 HTH_CROC1 # Pfam PF01381 HTH_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DICA_ECOLI HTH-type transcriptional regulator DicA # RefSeq NP_416088 NC_000913.3 # RefSeq WP_000448564 NZ_LN832404.1 # SIMILARITY Contains 1 HTH cro/C1-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00257}. # SMART SM00530 HTH_XRE # SUPFAM SSF47413 SSF47413 # eggNOG COG1396 LUCA # eggNOG ENOG41087BU Bacteria BLAST swissprot:DICA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DICA_ECOLI BioCyc ECOL316407:JW1562-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1562-MONOMER BioCyc EcoCyc:EG10226-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10226-MONOMER DOI 10.1007/BF00322439 http://dx.doi.org/10.1007/BF00322439 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/14.17.6821 http://dx.doi.org/10.1093/nar/14.17.6821 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X07465 http://www.ebi.ac.uk/ena/data/view/X07465 EchoBASE EB0222 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0222 EcoGene EG10226 http://www.ecogene.org/geneInfo.php?eg_id=EG10226 EnsemblBacteria AAC74643 http://www.ensemblgenomes.org/id/AAC74643 EnsemblBacteria AAC74643 http://www.ensemblgenomes.org/id/AAC74643 EnsemblBacteria BAA15275 http://www.ensemblgenomes.org/id/BAA15275 EnsemblBacteria BAA15275 http://www.ensemblgenomes.org/id/BAA15275 EnsemblBacteria BAA15275 http://www.ensemblgenomes.org/id/BAA15275 EnsemblBacteria b1570 http://www.ensemblgenomes.org/id/b1570 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 Gene3D 1.10.260.40 http://www.cathdb.info/version/latest/superfamily/1.10.260.40 GeneID 946241 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946241 HOGENOM HOG000120198 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120198&db=HOGENOM6 InParanoid P06966 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P06966 IntAct P06966 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P06966* InterPro IPR001387 http://www.ebi.ac.uk/interpro/entry/IPR001387 InterPro IPR010982 http://www.ebi.ac.uk/interpro/entry/IPR010982 KEGG_Gene ecj:JW1562 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1562 KEGG_Gene eco:b1570 http://www.genome.jp/dbget-bin/www_bget?eco:b1570 OMA NESIGAR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NESIGAR PROSITE PS50943 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50943 PSORT swissprot:DICA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DICA_ECOLI PSORT-B swissprot:DICA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DICA_ECOLI PSORT2 swissprot:DICA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DICA_ECOLI Pfam PF01381 http://pfam.xfam.org/family/PF01381 Phobius swissprot:DICA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DICA_ECOLI ProteinModelPortal P06966 http://www.proteinmodelportal.org/query/uniprot/P06966 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2836697 http://www.ncbi.nlm.nih.gov/pubmed/2836697 PubMed 3532030 http://www.ncbi.nlm.nih.gov/pubmed/3532030 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416088 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416088 RefSeq WP_000448564 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000448564 SMART SM00530 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00530 SMR P06966 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P06966 STRING 511145.b1570 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1570&targetmode=cogs SUPFAM SSF47413 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47413 UniProtKB DICA_ECOLI http://www.uniprot.org/uniprot/DICA_ECOLI UniProtKB-AC P06966 http://www.uniprot.org/uniprot/P06966 charge swissprot:DICA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DICA_ECOLI eggNOG COG1396 http://eggnogapi.embl.de/nog_data/html/tree/COG1396 eggNOG ENOG41087BU http://eggnogapi.embl.de/nog_data/html/tree/ENOG41087BU epestfind swissprot:DICA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DICA_ECOLI garnier swissprot:DICA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DICA_ECOLI helixturnhelix swissprot:DICA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DICA_ECOLI hmoment swissprot:DICA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DICA_ECOLI iep swissprot:DICA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DICA_ECOLI inforesidue swissprot:DICA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DICA_ECOLI octanol swissprot:DICA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DICA_ECOLI pepcoil swissprot:DICA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DICA_ECOLI pepdigest swissprot:DICA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DICA_ECOLI pepinfo swissprot:DICA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DICA_ECOLI pepnet swissprot:DICA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DICA_ECOLI pepstats swissprot:DICA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DICA_ECOLI pepwheel swissprot:DICA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DICA_ECOLI pepwindow swissprot:DICA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DICA_ECOLI sigcleave swissprot:DICA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DICA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261544 122 # EcoGene EG11635 nohD # Gene3D 1.10.10.10 -; 1. # IntAct P31062 12 # InterPro IPR009061 DNA-bd_dom_put # InterPro IPR010906 Phage_lambda_Nu1_terminase-ssu # InterPro IPR011991 WHTH_DNA-bd_dom # MISCELLANEOUS NOHD_ECOLI Encoded by the cryptic lambdoid prophage DLP12. # Organism NOHD_ECOLI Escherichia coli (strain K12) # PATRIC 32116288 VBIEscCol129921_0584 # PIR F64788 F64788 # Pfam PF07471 Phage_Nu1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NOHD_ECOLI DNA-packaging protein NU1 homolog # RefSeq NP_415092 NC_000913.3 # RefSeq WP_000453566 NZ_CP014272.1 # SIMILARITY To phage lambda DNA packaging protein NU1. {ECO 0000305}. # SUPFAM SSF46955 SSF46955 # eggNOG COG4220 LUCA # eggNOG ENOG4105FKG Bacteria BLAST swissprot:NOHD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NOHD_ECOLI BioCyc ECOL316407:JW0549-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0549-MONOMER BioCyc EcoCyc:EG11635-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11635-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/20.13.3357 http://dx.doi.org/10.1093/nar/20.13.3357 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D00928 http://www.ebi.ac.uk/ena/data/view/D00928 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1591 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1591 EcoGene EG11635 http://www.ecogene.org/geneInfo.php?eg_id=EG11635 EnsemblBacteria AAC73661 http://www.ensemblgenomes.org/id/AAC73661 EnsemblBacteria AAC73661 http://www.ensemblgenomes.org/id/AAC73661 EnsemblBacteria BAE76336 http://www.ensemblgenomes.org/id/BAE76336 EnsemblBacteria BAE76336 http://www.ensemblgenomes.org/id/BAE76336 EnsemblBacteria BAE76336 http://www.ensemblgenomes.org/id/BAE76336 EnsemblBacteria b0560 http://www.ensemblgenomes.org/id/b0560 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 945172 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945172 HOGENOM HOG000119387 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000119387&db=HOGENOM6 InParanoid P31062 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31062 IntAct P31062 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31062* InterPro IPR009061 http://www.ebi.ac.uk/interpro/entry/IPR009061 InterPro IPR010906 http://www.ebi.ac.uk/interpro/entry/IPR010906 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW0549 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0549 KEGG_Gene eco:b0560 http://www.genome.jp/dbget-bin/www_bget?eco:b0560 OMA TRTITTW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TRTITTW PSORT swissprot:NOHD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NOHD_ECOLI PSORT-B swissprot:NOHD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NOHD_ECOLI PSORT2 swissprot:NOHD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NOHD_ECOLI Pfam PF07471 http://pfam.xfam.org/family/PF07471 Phobius swissprot:NOHD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NOHD_ECOLI ProteinModelPortal P31062 http://www.proteinmodelportal.org/query/uniprot/P31062 PubMed 1630906 http://www.ncbi.nlm.nih.gov/pubmed/1630906 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415092 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415092 RefSeq WP_000453566 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000453566 SMR P31062 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31062 STRING 511145.b0560 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0560&targetmode=cogs SUPFAM SSF46955 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46955 UniProtKB NOHD_ECOLI http://www.uniprot.org/uniprot/NOHD_ECOLI UniProtKB-AC P31062 http://www.uniprot.org/uniprot/P31062 charge swissprot:NOHD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NOHD_ECOLI eggNOG COG4220 http://eggnogapi.embl.de/nog_data/html/tree/COG4220 eggNOG ENOG4105FKG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FKG epestfind swissprot:NOHD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NOHD_ECOLI garnier swissprot:NOHD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NOHD_ECOLI helixturnhelix swissprot:NOHD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NOHD_ECOLI hmoment swissprot:NOHD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NOHD_ECOLI iep swissprot:NOHD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NOHD_ECOLI inforesidue swissprot:NOHD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NOHD_ECOLI octanol swissprot:NOHD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NOHD_ECOLI pepcoil swissprot:NOHD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NOHD_ECOLI pepdigest swissprot:NOHD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NOHD_ECOLI pepinfo swissprot:NOHD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NOHD_ECOLI pepnet swissprot:NOHD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NOHD_ECOLI pepstats swissprot:NOHD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NOHD_ECOLI pepwheel swissprot:NOHD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NOHD_ECOLI pepwindow swissprot:NOHD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NOHD_ECOLI sigcleave swissprot:NOHD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NOHD_ECOLI ## Database ID URL or Descriptions # AltName YMFQ_ECOLI Uncharacterized protein YmfQ in lambdoid prophage e14 region # BioGrid 4262855 12 # EcoGene EG14255 ymfQ # InterPro IPR018755 Phage_Mu_Gp48 # Organism YMFQ_ECOLI Escherichia coli (strain K12) # PATRIC 32117543 VBIEscCol129921_1194 # PIR F64860 F64860 # Pfam PF10076 DUF2313 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Uncharacterized protein YmfQ {ECO 0000305} # RefSeq NP_415671 NC_000913.3 # RefSeq WP_000383574 NZ_CP010440.1 # SIMILARITY To phage Mu protein gp48 and H.influenzae HI_1521. {ECO 0000305}. # eggNOG COG3778 LUCA # eggNOG ENOG4105Y0G Bacteria BLAST swissprot:YMFQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YMFQ_ECOLI BioCyc ECOL316407:JW1139-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1139-MONOMER BioCyc EcoCyc:G6597-MONOMER http://biocyc.org/getid?id=EcoCyc:G6597-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4003 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4003 EcoGene EG14255 http://www.ecogene.org/geneInfo.php?eg_id=EG14255 EnsemblBacteria AAC74237 http://www.ensemblgenomes.org/id/AAC74237 EnsemblBacteria AAC74237 http://www.ensemblgenomes.org/id/AAC74237 EnsemblBacteria BAA35979 http://www.ensemblgenomes.org/id/BAA35979 EnsemblBacteria BAA35979 http://www.ensemblgenomes.org/id/BAA35979 EnsemblBacteria BAA35979 http://www.ensemblgenomes.org/id/BAA35979 EnsemblBacteria b1153 http://www.ensemblgenomes.org/id/b1153 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945707 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945707 HOGENOM HOG000123636 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000123636&db=HOGENOM6 InParanoid P75982 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75982 InterPro IPR018755 http://www.ebi.ac.uk/interpro/entry/IPR018755 KEGG_Gene ecj:JW1139 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1139 KEGG_Gene eco:b1153 http://www.genome.jp/dbget-bin/www_bget?eco:b1153 OMA AATNTTW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AATNTTW PSORT swissprot:YMFQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YMFQ_ECOLI PSORT-B swissprot:YMFQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YMFQ_ECOLI PSORT2 swissprot:YMFQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YMFQ_ECOLI Pfam PF10076 http://pfam.xfam.org/family/PF10076 Phobius swissprot:YMFQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YMFQ_ECOLI ProteinModelPortal P75982 http://www.proteinmodelportal.org/query/uniprot/P75982 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415671 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415671 RefSeq WP_000383574 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000383574 STRING 511145.b1153 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1153&targetmode=cogs UniProtKB YMFQ_ECOLI http://www.uniprot.org/uniprot/YMFQ_ECOLI UniProtKB-AC P75982 http://www.uniprot.org/uniprot/P75982 charge swissprot:YMFQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YMFQ_ECOLI eggNOG COG3778 http://eggnogapi.embl.de/nog_data/html/tree/COG3778 eggNOG ENOG4105Y0G http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105Y0G epestfind swissprot:YMFQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YMFQ_ECOLI garnier swissprot:YMFQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YMFQ_ECOLI helixturnhelix swissprot:YMFQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YMFQ_ECOLI hmoment swissprot:YMFQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YMFQ_ECOLI iep swissprot:YMFQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YMFQ_ECOLI inforesidue swissprot:YMFQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YMFQ_ECOLI octanol swissprot:YMFQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YMFQ_ECOLI pepcoil swissprot:YMFQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YMFQ_ECOLI pepdigest swissprot:YMFQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YMFQ_ECOLI pepinfo swissprot:YMFQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YMFQ_ECOLI pepnet swissprot:YMFQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YMFQ_ECOLI pepstats swissprot:YMFQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YMFQ_ECOLI pepwheel swissprot:YMFQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YMFQ_ECOLI pepwindow swissprot:YMFQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YMFQ_ECOLI sigcleave swissprot:YMFQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YMFQ_ECOLI ## Database ID URL or Descriptions # AltName PUR2_ECOLI GARS # AltName PUR2_ECOLI Glycinamide ribonucleotide synthetase # AltName PUR2_ECOLI Phosphoribosylglycinamide synthetase # BRENDA 6.3.4.13 2026 # BioGrid 4262462 10 # CATALYTIC ACTIVITY PUR2_ECOLI ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide. # COFACTOR PUR2_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000250}; Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit. {ECO 0000250}; # EcoGene EG10792 purD # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0004637 phosphoribosylamine-glycine ligase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IDA:EcoliWiki. # GO_function GO:0030145 manganese ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0042623 ATPase activity, coupled; IDA:EcoliWiki. # GO_process GO:0006164 purine nucleotide biosynthetic process; NAS:EcoliWiki. # GO_process GO:0006189 'de novo' IMP biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0009113 purine nucleobase biosynthetic process; IEA:InterPro. # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.30.1490.20 -; 1. # Gene3D 3.30.470.20 -; 1. # Gene3D 3.40.50.20 -; 1. # Gene3D 3.90.600.10 -; 1. # HAMAP MF_00138 GARS # IntAct P15640 4 # InterPro IPR000115 PRibGlycinamide_synth # InterPro IPR011054 Rudment_hybrid_motif # InterPro IPR011761 ATP-grasp # InterPro IPR013815 ATP_grasp_subdomain_1 # InterPro IPR013816 ATP_grasp_subdomain_2 # InterPro IPR016185 PreATP-grasp_dom # InterPro IPR020559 PRibGlycinamide_synth_CS # InterPro IPR020560 PRibGlycinamide_synth_C-dom # InterPro IPR020561 PRibGlycinamid_synth_ATP-grasp # InterPro IPR020562 PRibGlycinamide_synth_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # Organism PUR2_ECOLI Escherichia coli (strain K12) # PATHWAY Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D- ribose 1-diphosphate step 2/2. # PATRIC 32123535 VBIEscCol129921_4120 # PDB 1GSO X-ray; 1.60 A; A=1-429 # PIR A33771 AJECQG # PROSITE PS00184 GARS # PROSITE PS50975 ATP_GRASP # Pfam PF01071 GARS_A # Pfam PF02843 GARS_C # Pfam PF02844 GARS_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PUR2_ECOLI Phosphoribosylamine--glycine ligase # RefSeq NP_418433 NC_000913.3 # RefSeq WP_000866800 NZ_LN832404.1 # SIMILARITY Belongs to the GARS family. {ECO 0000305}. # SIMILARITY Contains 1 ATP-grasp domain. {ECO 0000305}. # SMART SM01210 GARS_C # SUBUNIT PUR2_ECOLI Monomer. # SUPFAM SSF51246 SSF51246 # SUPFAM SSF52440 SSF52440 # TIGRFAMs TIGR00877 purD # UniPathway UPA00074 UER00125 # eggNOG COG0151 LUCA # eggNOG ENOG4105C12 Bacteria BLAST swissprot:PUR2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PUR2_ECOLI BioCyc ECOL316407:JW3969-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3969-MONOMER BioCyc EcoCyc:GLYCRIBONUCSYN-MONOMER http://biocyc.org/getid?id=EcoCyc:GLYCRIBONUCSYN-MONOMER BioCyc MetaCyc:GLYCRIBONUCSYN-MONOMER http://biocyc.org/getid?id=MetaCyc:GLYCRIBONUCSYN-MONOMER COG COG0151 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0151 DOI 10.1021/bi00453a030 http://dx.doi.org/10.1021/bi00453a030 DOI 10.1021/bi981405n http://dx.doi.org/10.1021/bi981405n DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.3.4.13 http://www.genome.jp/dbget-bin/www_bget?EC:6.3.4.13 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J05126 http://www.ebi.ac.uk/ena/data/view/J05126 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X51950 http://www.ebi.ac.uk/ena/data/view/X51950 ENZYME 6.3.4.13 http://enzyme.expasy.org/EC/6.3.4.13 EchoBASE EB0785 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0785 EcoGene EG10792 http://www.ecogene.org/geneInfo.php?eg_id=EG10792 EnsemblBacteria AAC76979 http://www.ensemblgenomes.org/id/AAC76979 EnsemblBacteria AAC76979 http://www.ensemblgenomes.org/id/AAC76979 EnsemblBacteria BAE77314 http://www.ensemblgenomes.org/id/BAE77314 EnsemblBacteria BAE77314 http://www.ensemblgenomes.org/id/BAE77314 EnsemblBacteria BAE77314 http://www.ensemblgenomes.org/id/BAE77314 EnsemblBacteria b4005 http://www.ensemblgenomes.org/id/b4005 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0004637 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004637 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_function GO:0042623 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042623 GO_process GO:0006164 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006164 GO_process GO:0006189 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006189 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0009113 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009113 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.30.1490.20 http://www.cathdb.info/version/latest/superfamily/3.30.1490.20 Gene3D 3.30.470.20 http://www.cathdb.info/version/latest/superfamily/3.30.470.20 Gene3D 3.40.50.20 http://www.cathdb.info/version/latest/superfamily/3.40.50.20 Gene3D 3.90.600.10 http://www.cathdb.info/version/latest/superfamily/3.90.600.10 GeneID 948504 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948504 HAMAP MF_00138 http://hamap.expasy.org/unirule/MF_00138 HOGENOM HOG000033463 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000033463&db=HOGENOM6 InParanoid P15640 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P15640 IntAct P15640 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P15640* IntEnz 6.3.4.13 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.4.13 InterPro IPR000115 http://www.ebi.ac.uk/interpro/entry/IPR000115 InterPro IPR011054 http://www.ebi.ac.uk/interpro/entry/IPR011054 InterPro IPR011761 http://www.ebi.ac.uk/interpro/entry/IPR011761 InterPro IPR013815 http://www.ebi.ac.uk/interpro/entry/IPR013815 InterPro IPR013816 http://www.ebi.ac.uk/interpro/entry/IPR013816 InterPro IPR016185 http://www.ebi.ac.uk/interpro/entry/IPR016185 InterPro IPR020559 http://www.ebi.ac.uk/interpro/entry/IPR020559 InterPro IPR020560 http://www.ebi.ac.uk/interpro/entry/IPR020560 InterPro IPR020561 http://www.ebi.ac.uk/interpro/entry/IPR020561 InterPro IPR020562 http://www.ebi.ac.uk/interpro/entry/IPR020562 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3969 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3969 KEGG_Gene eco:b4005 http://www.genome.jp/dbget-bin/www_bget?eco:b4005 KEGG_Orthology KO:K01945 http://www.genome.jp/dbget-bin/www_bget?KO:K01945 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Reaction rn:R04144 http://www.genome.jp/dbget-bin/www_bget?rn:R04144 OMA VNGMAAE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VNGMAAE PDB 1GSO http://www.ebi.ac.uk/pdbe-srv/view/entry/1GSO PDBsum 1GSO http://www.ebi.ac.uk/pdbsum/1GSO PROSITE PS00184 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00184 PROSITE PS50975 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50975 PSORT swissprot:PUR2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PUR2_ECOLI PSORT-B swissprot:PUR2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PUR2_ECOLI PSORT2 swissprot:PUR2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PUR2_ECOLI Pfam PF01071 http://pfam.xfam.org/family/PF01071 Pfam PF02843 http://pfam.xfam.org/family/PF02843 Pfam PF02844 http://pfam.xfam.org/family/PF02844 Phobius swissprot:PUR2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PUR2_ECOLI PhylomeDB P15640 http://phylomedb.org/?seqid=P15640 ProteinModelPortal P15640 http://www.proteinmodelportal.org/query/uniprot/P15640 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2182115 http://www.ncbi.nlm.nih.gov/pubmed/2182115 PubMed 2687276 http://www.ncbi.nlm.nih.gov/pubmed/2687276 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9843369 http://www.ncbi.nlm.nih.gov/pubmed/9843369 RefSeq NP_418433 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418433 RefSeq WP_000866800 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000866800 SMART SM01210 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01210 SMR P15640 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P15640 STRING 511145.b4005 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4005&targetmode=cogs STRING COG0151 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0151&targetmode=cogs SUPFAM SSF51246 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51246 SUPFAM SSF52440 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52440 SWISS-2DPAGE P15640 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P15640 TIGRFAMs TIGR00877 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00877 UniProtKB PUR2_ECOLI http://www.uniprot.org/uniprot/PUR2_ECOLI UniProtKB-AC P15640 http://www.uniprot.org/uniprot/P15640 charge swissprot:PUR2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PUR2_ECOLI eggNOG COG0151 http://eggnogapi.embl.de/nog_data/html/tree/COG0151 eggNOG ENOG4105C12 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C12 epestfind swissprot:PUR2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PUR2_ECOLI garnier swissprot:PUR2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PUR2_ECOLI helixturnhelix swissprot:PUR2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PUR2_ECOLI hmoment swissprot:PUR2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PUR2_ECOLI iep swissprot:PUR2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PUR2_ECOLI inforesidue swissprot:PUR2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PUR2_ECOLI octanol swissprot:PUR2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PUR2_ECOLI pepcoil swissprot:PUR2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PUR2_ECOLI pepdigest swissprot:PUR2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PUR2_ECOLI pepinfo swissprot:PUR2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PUR2_ECOLI pepnet swissprot:PUR2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PUR2_ECOLI pepstats swissprot:PUR2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PUR2_ECOLI pepwheel swissprot:PUR2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PUR2_ECOLI pepwindow swissprot:PUR2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PUR2_ECOLI sigcleave swissprot:PUR2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PUR2_ECOLI ## Database ID URL or Descriptions # BioGrid 4261046 249 # EcoGene EG11977 fliR # FUNCTION FLIR_ECOLI Role in flagellar biosynthesis. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0009425 bacterial-type flagellum basal body; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006605 protein targeting; IEA:InterPro. # GO_process GO:0044780 bacterial-type flagellum assembly; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005622 intracellular # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006605 protein targeting # GOslim_process GO:0022607 cellular component assembly # IntAct P33135 4 # InterPro IPR002010 T3SS_IM_R # InterPro IPR006303 FliR # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko02040 Flagellar assembly # Organism FLIR_ECOLI Escherichia coli (strain K12) # PATRIC 32119229 VBIEscCol129921_2029 # PIR C64959 C64959 # PRINTS PR00953 TYPE3IMRPROT # Pfam PF01311 Bac_export_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FLIR_ECOLI Flagellar biosynthetic protein FliR # RefSeq NP_416460 NC_000913.3 # RefSeq WP_000942319 NZ_LN832404.1 # SIMILARITY Belongs to the FliR/MopE/SpaR family. {ECO 0000305}. # SUBCELLULAR LOCATION FLIR_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. Bacterial flagellum basal body {ECO 0000269|PubMed 15919996}. # TIGRFAMs TIGR01400 fliR # eggNOG COG1684 LUCA # eggNOG ENOG4105D19 Bacteria BLAST swissprot:FLIR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLIR_ECOLI BioCyc ECOL316407:JW1934-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1934-MONOMER BioCyc EcoCyc:EG11977-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11977-MONOMER COG COG1684 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1684 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L22182 http://www.ebi.ac.uk/ena/data/view/L22182 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1920 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1920 EcoGene EG11977 http://www.ecogene.org/geneInfo.php?eg_id=EG11977 EnsemblBacteria AAC75017 http://www.ensemblgenomes.org/id/AAC75017 EnsemblBacteria AAC75017 http://www.ensemblgenomes.org/id/AAC75017 EnsemblBacteria BAA15775 http://www.ensemblgenomes.org/id/BAA15775 EnsemblBacteria BAA15775 http://www.ensemblgenomes.org/id/BAA15775 EnsemblBacteria BAA15775 http://www.ensemblgenomes.org/id/BAA15775 EnsemblBacteria b1950 http://www.ensemblgenomes.org/id/b1950 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0009425 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009425 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006605 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006605 GO_process GO:0044780 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044780 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006605 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006605 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GeneID 946464 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946464 HOGENOM HOG000253545 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000253545&db=HOGENOM6 InParanoid P33135 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33135 IntAct P33135 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33135* InterPro IPR002010 http://www.ebi.ac.uk/interpro/entry/IPR002010 InterPro IPR006303 http://www.ebi.ac.uk/interpro/entry/IPR006303 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW1934 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1934 KEGG_Gene eco:b1950 http://www.genome.jp/dbget-bin/www_bget?eco:b1950 KEGG_Orthology KO:K02421 http://www.genome.jp/dbget-bin/www_bget?KO:K02421 KEGG_Pathway ko02040 http://www.genome.jp/kegg-bin/show_pathway?ko02040 OMA NLAFGVM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NLAFGVM PRINTS PR00953 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00953 PSORT swissprot:FLIR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLIR_ECOLI PSORT-B swissprot:FLIR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLIR_ECOLI PSORT2 swissprot:FLIR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLIR_ECOLI Pfam PF01311 http://pfam.xfam.org/family/PF01311 Phobius swissprot:FLIR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLIR_ECOLI PhylomeDB P33135 http://phylomedb.org/?seqid=P33135 ProteinModelPortal P33135 http://www.proteinmodelportal.org/query/uniprot/P33135 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8282695 http://www.ncbi.nlm.nih.gov/pubmed/8282695 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416460 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416460 RefSeq WP_000942319 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000942319 STRING 511145.b1950 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1950&targetmode=cogs STRING COG1684 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1684&targetmode=cogs TIGRFAMs TIGR01400 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01400 UniProtKB FLIR_ECOLI http://www.uniprot.org/uniprot/FLIR_ECOLI UniProtKB-AC P33135 http://www.uniprot.org/uniprot/P33135 charge swissprot:FLIR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLIR_ECOLI eggNOG COG1684 http://eggnogapi.embl.de/nog_data/html/tree/COG1684 eggNOG ENOG4105D19 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D19 epestfind swissprot:FLIR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLIR_ECOLI garnier swissprot:FLIR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLIR_ECOLI helixturnhelix swissprot:FLIR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLIR_ECOLI hmoment swissprot:FLIR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLIR_ECOLI iep swissprot:FLIR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLIR_ECOLI inforesidue swissprot:FLIR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLIR_ECOLI octanol swissprot:FLIR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLIR_ECOLI pepcoil swissprot:FLIR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLIR_ECOLI pepdigest swissprot:FLIR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLIR_ECOLI pepinfo swissprot:FLIR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLIR_ECOLI pepnet swissprot:FLIR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLIR_ECOLI pepstats swissprot:FLIR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLIR_ECOLI pepwheel swissprot:FLIR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLIR_ECOLI pepwindow swissprot:FLIR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLIR_ECOLI sigcleave swissprot:FLIR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLIR_ECOLI ## Database ID URL or Descriptions # AltName FtsZ interacting protein A {ECO:0000303|PubMed 9008158} # BioGrid 4261708 552 # CDD cd00231 ZipA # DOMAIN ZIPA_ECOLI Contains an N-terminal transmembrane domain, followed by a charged domain, an unstructured P/Q domain rich in proline and glutamine, and a C-terminal FtsZ-binding domain. {ECO 0000305|PubMed 12107152}. # EcoGene EG14169 zipA # FUNCTION ZIPA_ECOLI Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring (PubMed 9008158, PubMed 11847116, PubMed 22164258, PubMed 22304478, PubMed 23233671). Also required for the recruitment to the septal ring of the downstream cell division proteins FtsK, FtsQ, FtsL and FtsN (PubMed 11847116, PubMed 11948172). ZipA overproduction protects FtsZ from degradation by ClpP by preventing recognition by ClpX (PubMed 23233671). Does not affect the GTPase activity of FtsZ (PubMed 10209756). {ECO 0000269|PubMed 10209756, ECO 0000269|PubMed 11847116, ECO 0000269|PubMed 11948172, ECO 0000269|PubMed 22164258, ECO 0000269|PubMed 22304478, ECO 0000269|PubMed 23233671, ECO 0000269|PubMed 9008158}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoliWiki. # GO_component GO:0032153 cell division site; IDA:EcoliWiki. # GO_process GO:0000917 barrier septum assembly; IMP:EcoliWiki. # GO_process GO:0043093 FtsZ-dependent cytokinesis; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0008150 biological_process # GOslim_process GO:0022607 cellular component assembly # Gene3D 3.30.1400.10 -; 1. # HAMAP MF_00509 ZipA # INDUCTION Repressed 1.5-fold by hydroxyurea. {ECO:0000269|PubMed 20005847}. # INTERACTION ZIPA_ECOLI P0A9A6 ftsZ; NbExp=4; IntAct=EBI-1029213, EBI-370963; # IntAct P77173 2 # InterPro IPR007449 ZipA_FtsZ-bd_C # InterPro IPR011919 Cell_div_ZipA # KEGG_Brite ko03036 Chromosome # MISCELLANEOUS ZIPA_ECOLI Has been isolated as a 91 kDa complex containing ZipA-EptA and an unidentified 24 kDa protein (PubMed 16079137), but it was shown later that there is no physical interaction between ZipA and EptA (PubMed 22304478). {ECO 0000305|PubMed 16079137, ECO 0000305|PubMed 22304478}. # Organism ZIPA_ECOLI Escherichia coli (strain K12) # PATRIC 32120207 VBIEscCol129921_2506 # PDB 1F46 X-ray; 1.50 A; A/B=189-328 # PDB 1F47 X-ray; 1.95 A; B=185-328 # PDB 1F7W NMR; -; A=185-328 # PDB 1F7X NMR; -; A=185-328 # PDB 1S1J X-ray; 2.18 A; A/B=185-328 # PDB 1S1S X-ray; 2.10 A; A/B=185-328 # PDB 1Y2F X-ray; 2.00 A; A=190-328 # PDB 1Y2G X-ray; 1.90 A; A/B=189-328 # PIR C65015 C65015 # Pfam PF04354 ZipA_C # ProDom PD035754 ZipA_Fts_Z_bd_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Cell division protein ZipA {ECO:0000255|HAMAP-Rule MF_00509} # RefSeq NP_416907 NC_000913.3 # RefSeq WP_001300494 NZ_LN832404.1 # SIMILARITY Belongs to the ZipA family. {ECO:0000255|HAMAP- Rule MF_00509, ECO:0000305}. # SMART SM00771 ZipA_C # SUBCELLULAR LOCATION ZIPA_ECOLI Cell inner membrane {ECO 0000269|PubMed 16079137, ECO 0000269|PubMed 9008158}; Single- pass type I membrane protein {ECO 0000269|PubMed 9008158}. Note=Localizes to the Z ring in an FtsZ-dependent manner (PubMed 9008158, PubMed 9864327, PubMed 10209756). Localization does not depend upon FtsA or FtsI (PubMed 9864327, PubMed 10209756). {ECO 0000269|PubMed 10209756, ECO 0000269|PubMed 9008158, ECO 0000269|PubMed 9864327}. # SUBUNIT ZIPA_ECOLI Interacts with FtsZ via their C-terminal domains (PubMed 9008158, PubMed 10209756, PubMed 10880432, PubMed 22164258). Can form homodimers prior to association with FtsZ (PubMed 22304478). {ECO 0000269|PubMed 10209756, ECO 0000269|PubMed 10880432, ECO 0000269|PubMed 22164258, ECO 0000269|PubMed 22304478, ECO 0000269|PubMed 9008158}. # SUPFAM SSF64383 SSF64383 # TIGRFAMs TIGR02205 septum_zipA # eggNOG COG3115 LUCA # eggNOG ENOG4107NPY Bacteria BLAST swissprot:ZIPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ZIPA_ECOLI BioCyc ECOL316407:JW2404-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2404-MONOMER BioCyc EcoCyc:G7258-MONOMER http://biocyc.org/getid?id=EcoCyc:G7258-MONOMER COG COG3115 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3115 DIP DIP-1157N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-1157N DOI 10.1016/S0092-8674(00)81838-3 http://dx.doi.org/10.1016/S0092-8674(00)81838-3 DOI 10.1016/j.bmcl.2004.01.028 http://dx.doi.org/10.1016/j.bmcl.2004.01.028 DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1021/bi0009690 http://dx.doi.org/10.1021/bi0009690 DOI 10.1021/bi2015647 http://dx.doi.org/10.1021/bi2015647 DOI 10.1021/jm040163o http://dx.doi.org/10.1021/jm040163o DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1999.01322.x http://dx.doi.org/10.1046/j.1365-2958.1999.01322.x DOI 10.1074/jbc.M112.434944 http://dx.doi.org/10.1074/jbc.M112.434944 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/emboj/19.13.3179 http://dx.doi.org/10.1093/emboj/19.13.3179 DOI 10.1093/emboj/21.4.685 http://dx.doi.org/10.1093/emboj/21.4.685 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.15.4313-4315.2002 http://dx.doi.org/10.1128/JB.184.15.4313-4315.2002 DOI 10.1128/JB.184.9.2552-2556.2002 http://dx.doi.org/10.1128/JB.184.9.2552-2556.2002 DOI 10.1371/journal.pone.0028262 http://dx.doi.org/10.1371/journal.pone.0028262 DisProt DP00161 http://www.disprot.org/protein.php?id=DP00161 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U74650 http://www.ebi.ac.uk/ena/data/view/U74650 EchoBASE EB3921 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3921 EcoGene EG14169 http://www.ecogene.org/geneInfo.php?eg_id=EG14169 EnsemblBacteria AAC75465 http://www.ensemblgenomes.org/id/AAC75465 EnsemblBacteria AAC75465 http://www.ensemblgenomes.org/id/AAC75465 EnsemblBacteria BAA16284 http://www.ensemblgenomes.org/id/BAA16284 EnsemblBacteria BAA16284 http://www.ensemblgenomes.org/id/BAA16284 EnsemblBacteria BAA16284 http://www.ensemblgenomes.org/id/BAA16284 EnsemblBacteria b2412 http://www.ensemblgenomes.org/id/b2412 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0032153 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032153 GO_process GO:0000917 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000917 GO_process GO:0043093 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043093 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 Gene3D 3.30.1400.10 http://www.cathdb.info/version/latest/superfamily/3.30.1400.10 GeneID 946869 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946869 HAMAP MF_00509 http://hamap.expasy.org/unirule/MF_00509 HOGENOM HOG000274007 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000274007&db=HOGENOM6 InParanoid P77173 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77173 IntAct P77173 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77173* InterPro IPR007449 http://www.ebi.ac.uk/interpro/entry/IPR007449 InterPro IPR011919 http://www.ebi.ac.uk/interpro/entry/IPR011919 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene ecj:JW2404 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2404 KEGG_Gene eco:b2412 http://www.genome.jp/dbget-bin/www_bget?eco:b2412 KEGG_Orthology KO:K03528 http://www.genome.jp/dbget-bin/www_bget?KO:K03528 MINT MINT-89938 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-89938 OMA LPCYGEA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LPCYGEA PDB 1F46 http://www.ebi.ac.uk/pdbe-srv/view/entry/1F46 PDB 1F47 http://www.ebi.ac.uk/pdbe-srv/view/entry/1F47 PDB 1F7W http://www.ebi.ac.uk/pdbe-srv/view/entry/1F7W PDB 1F7X http://www.ebi.ac.uk/pdbe-srv/view/entry/1F7X PDB 1S1J http://www.ebi.ac.uk/pdbe-srv/view/entry/1S1J PDB 1S1S http://www.ebi.ac.uk/pdbe-srv/view/entry/1S1S PDB 1Y2F http://www.ebi.ac.uk/pdbe-srv/view/entry/1Y2F PDB 1Y2G http://www.ebi.ac.uk/pdbe-srv/view/entry/1Y2G PDBsum 1F46 http://www.ebi.ac.uk/pdbsum/1F46 PDBsum 1F47 http://www.ebi.ac.uk/pdbsum/1F47 PDBsum 1F7W http://www.ebi.ac.uk/pdbsum/1F7W PDBsum 1F7X http://www.ebi.ac.uk/pdbsum/1F7X PDBsum 1S1J http://www.ebi.ac.uk/pdbsum/1S1J PDBsum 1S1S http://www.ebi.ac.uk/pdbsum/1S1S PDBsum 1Y2F http://www.ebi.ac.uk/pdbsum/1Y2F PDBsum 1Y2G http://www.ebi.ac.uk/pdbsum/1Y2G PSORT swissprot:ZIPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ZIPA_ECOLI PSORT-B swissprot:ZIPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ZIPA_ECOLI PSORT2 swissprot:ZIPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ZIPA_ECOLI Pfam PF04354 http://pfam.xfam.org/family/PF04354 Phobius swissprot:ZIPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ZIPA_ECOLI ProteinModelPortal P77173 http://www.proteinmodelportal.org/query/uniprot/P77173 PubMed 10209756 http://www.ncbi.nlm.nih.gov/pubmed/10209756 PubMed 10880432 http://www.ncbi.nlm.nih.gov/pubmed/10880432 PubMed 10924108 http://www.ncbi.nlm.nih.gov/pubmed/10924108 PubMed 11847116 http://www.ncbi.nlm.nih.gov/pubmed/11847116 PubMed 11948172 http://www.ncbi.nlm.nih.gov/pubmed/11948172 PubMed 12107152 http://www.ncbi.nlm.nih.gov/pubmed/12107152 PubMed 15006376 http://www.ncbi.nlm.nih.gov/pubmed/15006376 PubMed 15743191 http://www.ncbi.nlm.nih.gov/pubmed/15743191 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 22164258 http://www.ncbi.nlm.nih.gov/pubmed/22164258 PubMed 22304478 http://www.ncbi.nlm.nih.gov/pubmed/22304478 PubMed 23233671 http://www.ncbi.nlm.nih.gov/pubmed/23233671 PubMed 9008158 http://www.ncbi.nlm.nih.gov/pubmed/9008158 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9864327 http://www.ncbi.nlm.nih.gov/pubmed/9864327 RefSeq NP_416907 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416907 RefSeq WP_001300494 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300494 SMART SM00771 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00771 SMR P77173 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77173 STRING 511145.b2412 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2412&targetmode=cogs STRING COG3115 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3115&targetmode=cogs SUPFAM SSF64383 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF64383 TIGRFAMs TIGR02205 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02205 UniProtKB ZIPA_ECOLI http://www.uniprot.org/uniprot/ZIPA_ECOLI UniProtKB-AC P77173 http://www.uniprot.org/uniprot/P77173 charge swissprot:ZIPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ZIPA_ECOLI eggNOG COG3115 http://eggnogapi.embl.de/nog_data/html/tree/COG3115 eggNOG ENOG4107NPY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107NPY epestfind swissprot:ZIPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ZIPA_ECOLI garnier swissprot:ZIPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ZIPA_ECOLI helixturnhelix swissprot:ZIPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ZIPA_ECOLI hmoment swissprot:ZIPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ZIPA_ECOLI iep swissprot:ZIPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ZIPA_ECOLI inforesidue swissprot:ZIPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ZIPA_ECOLI octanol swissprot:ZIPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ZIPA_ECOLI pepcoil swissprot:ZIPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ZIPA_ECOLI pepdigest swissprot:ZIPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ZIPA_ECOLI pepinfo swissprot:ZIPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ZIPA_ECOLI pepnet swissprot:ZIPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ZIPA_ECOLI pepstats swissprot:ZIPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ZIPA_ECOLI pepwheel swissprot:ZIPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ZIPA_ECOLI pepwindow swissprot:ZIPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ZIPA_ECOLI sigcleave swissprot:ZIPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ZIPA_ECOLI ## Database ID URL or Descriptions # AltName GFCA_ECOLI Group 4 capsule protein A homolog # BioGrid 4262044 9 # CAUTION In E.coli K12 / MG1655 and K12 / W3110 this operon is silenced by an IS1D insertion in the promoter region. {ECO 0000305}. # EcoGene EG13732 gfcA # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # Organism GFCA_ECOLI Escherichia coli (strain K12) # PATRIC 32117197 VBIEscCol129921_1022 # PIR A64840 A64840 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GFCA_ECOLI Threonine-rich inner membrane protein GfcA # RefSeq NP_415507 NC_000913.3 # RefSeq WP_001295358 NZ_LN832404.1 # SUBCELLULAR LOCATION GFCA_ECOLI Cell inner membrane; Single-pass membrane protein. Note=When the protein is overexpressed. BLAST swissprot:GFCA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GFCA_ECOLI BioCyc ECOL316407:JW5133-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5133-MONOMER BioCyc EcoCyc:G6508-MONOMER http://biocyc.org/getid?id=EcoCyc:G6508-MONOMER DIP DIP-12710N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12710N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3496 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3496 EcoGene EG13732 http://www.ecogene.org/geneInfo.php?eg_id=EG13732 EnsemblBacteria AAC74072 http://www.ensemblgenomes.org/id/AAC74072 EnsemblBacteria AAC74072 http://www.ensemblgenomes.org/id/AAC74072 EnsemblBacteria BAA35752 http://www.ensemblgenomes.org/id/BAA35752 EnsemblBacteria BAA35752 http://www.ensemblgenomes.org/id/BAA35752 EnsemblBacteria BAA35752 http://www.ensemblgenomes.org/id/BAA35752 EnsemblBacteria b0987 http://www.ensemblgenomes.org/id/b0987 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 945029 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945029 HOGENOM HOG000009401 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009401&db=HOGENOM6 IntAct P75885 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75885* KEGG_Gene ecj:JW5133 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5133 KEGG_Gene eco:b0987 http://www.genome.jp/dbget-bin/www_bget?eco:b0987 OMA KRKVMKH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KRKVMKH PSORT swissprot:GFCA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GFCA_ECOLI PSORT-B swissprot:GFCA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GFCA_ECOLI PSORT2 swissprot:GFCA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GFCA_ECOLI Phobius swissprot:GFCA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GFCA_ECOLI ProteinModelPortal P75885 http://www.proteinmodelportal.org/query/uniprot/P75885 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415507 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415507 RefSeq WP_001295358 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295358 STRING 511145.b0987 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0987&targetmode=cogs UniProtKB GFCA_ECOLI http://www.uniprot.org/uniprot/GFCA_ECOLI UniProtKB-AC P75885 http://www.uniprot.org/uniprot/P75885 charge swissprot:GFCA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GFCA_ECOLI epestfind swissprot:GFCA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GFCA_ECOLI garnier swissprot:GFCA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GFCA_ECOLI helixturnhelix swissprot:GFCA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GFCA_ECOLI hmoment swissprot:GFCA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GFCA_ECOLI iep swissprot:GFCA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GFCA_ECOLI inforesidue swissprot:GFCA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GFCA_ECOLI octanol swissprot:GFCA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GFCA_ECOLI pepcoil swissprot:GFCA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GFCA_ECOLI pepdigest swissprot:GFCA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GFCA_ECOLI pepinfo swissprot:GFCA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GFCA_ECOLI pepnet swissprot:GFCA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GFCA_ECOLI pepstats swissprot:GFCA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GFCA_ECOLI pepwheel swissprot:GFCA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GFCA_ECOLI pepwindow swissprot:GFCA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GFCA_ECOLI sigcleave swissprot:GFCA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GFCA_ECOLI ## Database ID URL or Descriptions # BioGrid 4263497 21 # EcoGene EG12959 syd # FUNCTION SYDP_ECOLI Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function. # GO_component GO:0005737 cytoplasm; IDA:EcoCyc. # GO_component GO:0031234 extrinsic component of cytoplasmic side of plasma membrane; IDA:EcoCyc. # GO_process GO:0043254 regulation of protein complex assembly; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_process GO:0008150 biological_process # HAMAP MF_01104 Syd # InterPro IPR009948 Syd # Organism SYDP_ECOLI Escherichia coli (strain K12) # PATRIC 32121002 VBIEscCol129921_2893 # PDB 3FFV X-ray; 2.00 A; A/B=1-181 # PIR A55944 A55944 # Pfam PF07348 Syd # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SYDP_ECOLI Protein Syd # RefSeq NP_417273 NC_000913.3 # RefSeq WP_000342431 NZ_LN832404.1 # SIMILARITY Belongs to the Syd family. {ECO 0000305}. # SUBCELLULAR LOCATION SYDP_ECOLI Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Loosely associated with the cytoplasmic side of the inner membrane, probably via SecY. # eggNOG ENOG4108T6E Bacteria # eggNOG ENOG4111WE9 LUCA BLAST swissprot:SYDP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SYDP_ECOLI BioCyc ECOL316407:JW2764-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2764-MONOMER BioCyc EcoCyc:G7451-MONOMER http://biocyc.org/getid?id=EcoCyc:G7451-MONOMER DIP DIP-48106N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48106N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.270.10.5519 http://dx.doi.org/10.1074/jbc.270.10.5519 DOI 10.1074/jbc.273.30.18835 http://dx.doi.org/10.1074/jbc.273.30.18835 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D38520 http://www.ebi.ac.uk/ena/data/view/D38520 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 EchoBASE EB2792 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2792 EcoGene EG12959 http://www.ecogene.org/geneInfo.php?eg_id=EG12959 EnsemblBacteria AAC75835 http://www.ensemblgenomes.org/id/AAC75835 EnsemblBacteria AAC75835 http://www.ensemblgenomes.org/id/AAC75835 EnsemblBacteria BAE76865 http://www.ensemblgenomes.org/id/BAE76865 EnsemblBacteria BAE76865 http://www.ensemblgenomes.org/id/BAE76865 EnsemblBacteria BAE76865 http://www.ensemblgenomes.org/id/BAE76865 EnsemblBacteria b2793 http://www.ensemblgenomes.org/id/b2793 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0031234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031234 GO_process GO:0043254 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043254 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 947271 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947271 HAMAP MF_01104 http://hamap.expasy.org/unirule/MF_01104 HOGENOM HOG000218409 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218409&db=HOGENOM6 InterPro IPR009948 http://www.ebi.ac.uk/interpro/entry/IPR009948 KEGG_Gene ecj:JW2764 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2764 KEGG_Gene eco:b2793 http://www.genome.jp/dbget-bin/www_bget?eco:b2793 KEGG_Orthology KO:K15723 http://www.genome.jp/dbget-bin/www_bget?KO:K15723 OMA GIPSPCI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GIPSPCI PDB 3FFV http://www.ebi.ac.uk/pdbe-srv/view/entry/3FFV PDBsum 3FFV http://www.ebi.ac.uk/pdbsum/3FFV PSORT swissprot:SYDP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SYDP_ECOLI PSORT-B swissprot:SYDP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SYDP_ECOLI PSORT2 swissprot:SYDP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SYDP_ECOLI Pfam PF07348 http://pfam.xfam.org/family/PF07348 Phobius swissprot:SYDP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SYDP_ECOLI ProteinModelPortal P0A8U0 http://www.proteinmodelportal.org/query/uniprot/P0A8U0 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7890670 http://www.ncbi.nlm.nih.gov/pubmed/7890670 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9668058 http://www.ncbi.nlm.nih.gov/pubmed/9668058 RefSeq NP_417273 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417273 RefSeq WP_000342431 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000342431 SMR P0A8U0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8U0 STRING 511145.b2793 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2793&targetmode=cogs UniProtKB SYDP_ECOLI http://www.uniprot.org/uniprot/SYDP_ECOLI UniProtKB-AC P0A8U0 http://www.uniprot.org/uniprot/P0A8U0 charge swissprot:SYDP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SYDP_ECOLI eggNOG ENOG4108T6E http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108T6E eggNOG ENOG4111WE9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111WE9 epestfind swissprot:SYDP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SYDP_ECOLI garnier swissprot:SYDP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SYDP_ECOLI helixturnhelix swissprot:SYDP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SYDP_ECOLI hmoment swissprot:SYDP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SYDP_ECOLI iep swissprot:SYDP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SYDP_ECOLI inforesidue swissprot:SYDP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SYDP_ECOLI octanol swissprot:SYDP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SYDP_ECOLI pepcoil swissprot:SYDP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SYDP_ECOLI pepdigest swissprot:SYDP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SYDP_ECOLI pepinfo swissprot:SYDP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SYDP_ECOLI pepnet swissprot:SYDP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SYDP_ECOLI pepstats swissprot:SYDP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SYDP_ECOLI pepwheel swissprot:SYDP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SYDP_ECOLI pepwindow swissprot:SYDP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SYDP_ECOLI sigcleave swissprot:SYDP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SYDP_ECOLI ## Database ID URL or Descriptions # AltName PUR7_ECOLI SAICAR synthetase # BRENDA 6.3.2 2026 # BioGrid 4261983 23 # CATALYTIC ACTIVITY PUR7_ECOLI ATP + 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate. # EcoGene EG10791 purC # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0004638 phosphoribosylaminoimidazole carboxylase activity; IBA:GO_Central. # GO_function GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0006189 'de novo' IMP biosynthetic process; IBA:GO_Central. # GO_process GO:0046084 adenine biosynthetic process; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.30.470.20 -; 1. # HAMAP MF_00137 SAICAR_synth # IntAct P0A7D7 17 # InterPro IPR001636 SAICAR_synth # InterPro IPR013816 ATP_grasp_subdomain_2 # InterPro IPR018236 SAICAR_synthetase_CS # InterPro IPR028923 SAICAR_synt/ADE2_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # Organism PUR7_ECOLI Escherichia coli (strain K12) # PATHWAY Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5- amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate step 1/2. # PATRIC 32120337 VBIEscCol129921_2571 # PDB 2GQR X-ray; 2.00 A; A/B=1-237 # PDB 2GQS X-ray; 2.05 A; A/B=1-237 # PIR C36146 C36146 # PROSITE PS01057 SAICAR_SYNTHETASE_1 # PROSITE PS01058 SAICAR_SYNTHETASE_2 # Pfam PF01259 SAICAR_synt # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PUR7_ECOLI Phosphoribosylaminoimidazole-succinocarboxamide synthase # RefSeq NP_416971 NC_000913.3 # RefSeq WP_001295467 NZ_LN832404.1 # SIMILARITY Belongs to the SAICAR synthetase family. {ECO 0000305}. # SUBUNIT PUR7_ECOLI Homotrimer. # TIGRFAMs TIGR00081 purC # UniPathway UPA00074 UER00131 # eggNOG COG0152 LUCA # eggNOG ENOG4105C8V Bacteria BLAST swissprot:PUR7_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PUR7_ECOLI BioCyc ECOL316407:JW2461-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2461-MONOMER BioCyc EcoCyc:SAICARSYN-MONOMER http://biocyc.org/getid?id=EcoCyc:SAICARSYN-MONOMER BioCyc MetaCyc:SAICARSYN-MONOMER http://biocyc.org/getid?id=MetaCyc:SAICARSYN-MONOMER COG COG0152 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0152 DIP DIP-35900N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35900N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1021/bi00136a016 http://dx.doi.org/10.1021/bi00136a016 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.3.2.6 http://www.genome.jp/dbget-bin/www_bget?EC:6.3.2.6 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M33928 http://www.ebi.ac.uk/ena/data/view/M33928 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X57402 http://www.ebi.ac.uk/ena/data/view/X57402 ENZYME 6.3.2.6 http://enzyme.expasy.org/EC/6.3.2.6 EchoBASE EB0784 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0784 EcoGene EG10791 http://www.ecogene.org/geneInfo.php?eg_id=EG10791 EnsemblBacteria AAC75529 http://www.ensemblgenomes.org/id/AAC75529 EnsemblBacteria AAC75529 http://www.ensemblgenomes.org/id/AAC75529 EnsemblBacteria BAA16353 http://www.ensemblgenomes.org/id/BAA16353 EnsemblBacteria BAA16353 http://www.ensemblgenomes.org/id/BAA16353 EnsemblBacteria BAA16353 http://www.ensemblgenomes.org/id/BAA16353 EnsemblBacteria b2476 http://www.ensemblgenomes.org/id/b2476 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0004638 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004638 GO_function GO:0004639 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004639 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006189 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006189 GO_process GO:0046084 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046084 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.30.470.20 http://www.cathdb.info/version/latest/superfamily/3.30.470.20 GeneID 946957 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946957 HAMAP MF_00137 http://hamap.expasy.org/unirule/MF_00137 HOGENOM HOG000082629 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000082629&db=HOGENOM6 InParanoid P0A7D7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7D7 IntAct P0A7D7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7D7* IntEnz 6.3.2.6 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.2.6 InterPro IPR001636 http://www.ebi.ac.uk/interpro/entry/IPR001636 InterPro IPR013816 http://www.ebi.ac.uk/interpro/entry/IPR013816 InterPro IPR018236 http://www.ebi.ac.uk/interpro/entry/IPR018236 InterPro IPR028923 http://www.ebi.ac.uk/interpro/entry/IPR028923 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2461 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2461 KEGG_Gene eco:b2476 http://www.genome.jp/dbget-bin/www_bget?eco:b2476 KEGG_Orthology KO:K01923 http://www.genome.jp/dbget-bin/www_bget?KO:K01923 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Reaction rn:R04591 http://www.genome.jp/dbget-bin/www_bget?rn:R04591 MINT MINT-1257522 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1257522 OMA FNAQKRG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FNAQKRG PDB 2GQR http://www.ebi.ac.uk/pdbe-srv/view/entry/2GQR PDB 2GQS http://www.ebi.ac.uk/pdbe-srv/view/entry/2GQS PDBsum 2GQR http://www.ebi.ac.uk/pdbsum/2GQR PDBsum 2GQS http://www.ebi.ac.uk/pdbsum/2GQS PROSITE PS01057 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01057 PROSITE PS01058 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01058 PSORT swissprot:PUR7_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PUR7_ECOLI PSORT-B swissprot:PUR7_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PUR7_ECOLI PSORT2 swissprot:PUR7_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PUR7_ECOLI Pfam PF01259 http://pfam.xfam.org/family/PF01259 Phobius swissprot:PUR7_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PUR7_ECOLI PhylomeDB P0A7D7 http://phylomedb.org/?seqid=P0A7D7 ProteinModelPortal P0A7D7 http://www.proteinmodelportal.org/query/uniprot/P0A7D7 PubMed 1534690 http://www.ncbi.nlm.nih.gov/pubmed/1534690 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1885529 http://www.ncbi.nlm.nih.gov/pubmed/1885529 PubMed 2120198 http://www.ncbi.nlm.nih.gov/pubmed/2120198 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_416971 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416971 RefSeq WP_001295467 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295467 SMR P0A7D7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7D7 STRING 511145.b2476 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2476&targetmode=cogs STRING COG0152 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0152&targetmode=cogs SWISS-2DPAGE P0A7D7 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A7D7 TIGRFAMs TIGR00081 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00081 UniProtKB PUR7_ECOLI http://www.uniprot.org/uniprot/PUR7_ECOLI UniProtKB-AC P0A7D7 http://www.uniprot.org/uniprot/P0A7D7 charge swissprot:PUR7_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PUR7_ECOLI eggNOG COG0152 http://eggnogapi.embl.de/nog_data/html/tree/COG0152 eggNOG ENOG4105C8V http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C8V epestfind swissprot:PUR7_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PUR7_ECOLI garnier swissprot:PUR7_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PUR7_ECOLI helixturnhelix swissprot:PUR7_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PUR7_ECOLI hmoment swissprot:PUR7_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PUR7_ECOLI iep swissprot:PUR7_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PUR7_ECOLI inforesidue swissprot:PUR7_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PUR7_ECOLI octanol swissprot:PUR7_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PUR7_ECOLI pepcoil swissprot:PUR7_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PUR7_ECOLI pepdigest swissprot:PUR7_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PUR7_ECOLI pepinfo swissprot:PUR7_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PUR7_ECOLI pepnet swissprot:PUR7_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PUR7_ECOLI pepstats swissprot:PUR7_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PUR7_ECOLI pepwheel swissprot:PUR7_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PUR7_ECOLI pepwindow swissprot:PUR7_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PUR7_ECOLI sigcleave swissprot:PUR7_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PUR7_ECOLI ## Database ID URL or Descriptions # AltName HOA_ECOLI 4-hydroxy-2-keto-pentanoic acid aldolase # AltName HOA_ECOLI 4-hydroxy-2-oxopentanoate aldolase # BIOPHYSICOCHEMICAL PROPERTIES pH dependence: Optimum pH is 6.25-6.75. {ECO 0000269|PubMed:9758851}; # BioGrid 4261624 11 # CATALYTIC ACTIVITY HOA_ECOLI (S)-4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate. # EcoGene EG13292 mhpE # FUNCTION HOA_ECOLI Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of 3-phenylpropanoate. {ECO 0000269|PubMed 9758851}. # GO_function GO:0008701 4-hydroxy-2-oxovalerate aldolase activity; IDA:EcoCyc. # GO_function GO:0030145 manganese ion binding; IEA:UniProtKB-HAMAP. # GO_process GO:0019380 3-phenylpropionate catabolic process; IEA:UniProtKB-UniPathway. # GO_process GO:0019439 aromatic compound catabolic process; IEA:UniProtKB-HAMAP. # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.70 -; 1. # HAMAP MF_01656 HOA # IntAct P51020 11 # InterPro IPR000891 PYR_CT # InterPro IPR012425 DmpG_comm # InterPro IPR013785 Aldolase_TIM # InterPro IPR017629 4OH_2_O-val_aldolase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00360 Phenylalanine metabolism # KEGG_Pathway ko00362 Benzoate degradation # KEGG_Pathway ko00621 Dioxin degradation # KEGG_Pathway ko00622 Xylene degradation # MISCELLANEOUS HOA_ECOLI Presumably stereoselective for the 4S-enantiomer of 4-hydroxy-2-ketovalerate. # Organism HOA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10277:SF3 PTHR10277:SF3 # PATHWAY HOA_ECOLI Aromatic compound metabolism; 3-phenylpropanoate degradation. # PATRIC 32115837 VBIEscCol129921_0360 # PIR H64762 H64762 # PROSITE PS50991 PYR_CT # Pfam PF00682 HMGL-like # Pfam PF07836 DmpG_comm # ProDom PD005364 DmpG_comm # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HOA_ECOLI 4-hydroxy-2-oxovalerate aldolase # RefSeq NP_414886 NC_000913.3 # RefSeq WP_001013499 NZ_LN832404.1 # SIMILARITY Belongs to the 4-hydroxy-2-oxovalerate aldolase family. {ECO 0000305}. # SIMILARITY Contains 1 pyruvate carboxyltransferase domain. {ECO:0000255|PROSITE-ProRule PRU01151}. # SUBUNIT Interacts with MhpF. {ECO:0000269|PubMed 16782065}. # TIGRFAMs TIGR03217 4OH_2_O_val_ald # eggNOG COG0119 LUCA # eggNOG ENOG4105DF3 Bacteria BLAST swissprot:HOA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HOA_ECOLI BioCyc ECOL316407:JW0343-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0343-MONOMER BioCyc EcoCyc:MHPELY-MONOMER http://biocyc.org/getid?id=EcoCyc:MHPELY-MONOMER BioCyc MetaCyc:MHPELY-MONOMER http://biocyc.org/getid?id=MetaCyc:MHPELY-MONOMER COG COG0119 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0119 DIP DIP-10209N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10209N DOI 10.1016/j.bbrc.2006.06.009 http://dx.doi.org/10.1016/j.bbrc.2006.06.009 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.1.3.39 http://www.genome.jp/dbget-bin/www_bget?EC:4.1.3.39 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D85613 http://www.ebi.ac.uk/ena/data/view/D85613 EMBL D86239 http://www.ebi.ac.uk/ena/data/view/D86239 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 ENZYME 4.1.3.39 http://enzyme.expasy.org/EC/4.1.3.39 EchoBASE EB3077 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3077 EcoGene EG13292 http://www.ecogene.org/geneInfo.php?eg_id=EG13292 EnsemblBacteria AAC73455 http://www.ensemblgenomes.org/id/AAC73455 EnsemblBacteria AAC73455 http://www.ensemblgenomes.org/id/AAC73455 EnsemblBacteria BAE76134 http://www.ensemblgenomes.org/id/BAE76134 EnsemblBacteria BAE76134 http://www.ensemblgenomes.org/id/BAE76134 EnsemblBacteria BAE76134 http://www.ensemblgenomes.org/id/BAE76134 EnsemblBacteria b0352 http://www.ensemblgenomes.org/id/b0352 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008701 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008701 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_process GO:0019380 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019380 GO_process GO:0019439 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019439 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 945012 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945012 HAMAP MF_01656 http://hamap.expasy.org/unirule/MF_01656 HOGENOM HOG000048047 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000048047&db=HOGENOM6 InParanoid P51020 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P51020 IntAct P51020 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P51020* IntEnz 4.1.3.39 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.3.39 InterPro IPR000891 http://www.ebi.ac.uk/interpro/entry/IPR000891 InterPro IPR012425 http://www.ebi.ac.uk/interpro/entry/IPR012425 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR017629 http://www.ebi.ac.uk/interpro/entry/IPR017629 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0343 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0343 KEGG_Gene eco:b0352 http://www.genome.jp/dbget-bin/www_bget?eco:b0352 KEGG_Orthology KO:K01666 http://www.genome.jp/dbget-bin/www_bget?KO:K01666 KEGG_Pathway ko00360 http://www.genome.jp/kegg-bin/show_pathway?ko00360 KEGG_Pathway ko00362 http://www.genome.jp/kegg-bin/show_pathway?ko00362 KEGG_Pathway ko00621 http://www.genome.jp/kegg-bin/show_pathway?ko00621 KEGG_Pathway ko00622 http://www.genome.jp/kegg-bin/show_pathway?ko00622 KEGG_Reaction rn:R00750 http://www.genome.jp/dbget-bin/www_bget?rn:R00750 KEGG_Reaction rn:R05298 http://www.genome.jp/dbget-bin/www_bget?rn:R05298 OMA PETATGM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PETATGM PANTHER PTHR10277:SF3 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10277:SF3 PROSITE PS50991 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50991 PSORT swissprot:HOA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HOA_ECOLI PSORT-B swissprot:HOA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HOA_ECOLI PSORT2 swissprot:HOA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HOA_ECOLI Pfam PF00682 http://pfam.xfam.org/family/PF00682 Pfam PF07836 http://pfam.xfam.org/family/PF07836 Phobius swissprot:HOA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HOA_ECOLI PhylomeDB P51020 http://phylomedb.org/?seqid=P51020 ProteinModelPortal P51020 http://www.proteinmodelportal.org/query/uniprot/P51020 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16782065 http://www.ncbi.nlm.nih.gov/pubmed/16782065 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9758851 http://www.ncbi.nlm.nih.gov/pubmed/9758851 RefSeq NP_414886 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414886 RefSeq WP_001013499 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001013499 SMR P51020 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P51020 STRING 511145.b0352 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0352&targetmode=cogs STRING COG0119 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0119&targetmode=cogs TIGRFAMs TIGR03217 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03217 UniProtKB HOA_ECOLI http://www.uniprot.org/uniprot/HOA_ECOLI UniProtKB-AC P51020 http://www.uniprot.org/uniprot/P51020 charge swissprot:HOA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HOA_ECOLI eggNOG COG0119 http://eggnogapi.embl.de/nog_data/html/tree/COG0119 eggNOG ENOG4105DF3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DF3 epestfind swissprot:HOA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HOA_ECOLI garnier swissprot:HOA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HOA_ECOLI helixturnhelix swissprot:HOA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HOA_ECOLI hmoment swissprot:HOA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HOA_ECOLI iep swissprot:HOA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HOA_ECOLI inforesidue swissprot:HOA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HOA_ECOLI octanol swissprot:HOA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HOA_ECOLI pepcoil swissprot:HOA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HOA_ECOLI pepdigest swissprot:HOA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HOA_ECOLI pepinfo swissprot:HOA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HOA_ECOLI pepnet swissprot:HOA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HOA_ECOLI pepstats swissprot:HOA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HOA_ECOLI pepwheel swissprot:HOA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HOA_ECOLI pepwindow swissprot:HOA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HOA_ECOLI sigcleave swissprot:HOA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HOA_ECOLI ## Database ID URL or Descriptions # AltName ENTF_ECOLI Enterochelin synthase F # AltName ENTF_ECOLI Serine-activating enzyme # AltName ENTF_ECOLI Seryl-AMP ligase # BRENDA 6.3.2.14 2026 # BioGrid 4259895 295 # CATALYTIC ACTIVITY ENTF_ECOLI ATP + L-serine = diphosphate + L-serine- adenylate. # COFACTOR Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI 47942; Note=Binds 1 phosphopantetheine covalently.; # ESTHER ecoli-entf Thioesterase # EcoGene EG10264 entF # FUNCTION ENTF_ECOLI Activates the carboxylate group of L-serine via ATP- dependent PPi exchange reactions to the aminoacyladenylate, preparing that molecule for the final stages of enterobactin synthesis. Holo-EntF acts as the catalyst for the formation of the three amide and three ester bonds present in the cyclic (2,3- dihydroxybenzoyl)serine trimer enterobactin, using seryladenylate and acyl-holo-EntB (acylated with 2,3-dihydroxybenzoate by EntE). # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0009366 enterobactin synthetase complex; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016779 nucleotidyltransferase activity; IDA:UniProtKB. # GO_function GO:0016788 hydrolase activity, acting on ester bonds; IEA:InterPro. # GO_function GO:0031177 phosphopantetheine binding; IDA:EcoCyc. # GO_function GO:0047527 2,3-dihydroxybenzoate-serine ligase activity; IDA:UniProtKB. # GO_process GO:0009239 enterobactin biosynthetic process; IMP:EcoCyc. # GO_process GO:0043041 amino acid activation for nonribosomal peptide biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0019748 secondary metabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 1.10.1200.10 -; 1. # Gene3D 3.40.50.1820 -; 2. # INDUCTION ENTF_ECOLI Transcriptionally regulated by iron and the fur protein. # IntAct P11454 10 # InterPro IPR000873 AMP-dep_Synth/Lig # InterPro IPR001031 Thioesterase # InterPro IPR001242 Condensatn # InterPro IPR006162 Ppantetheine_attach_site # InterPro IPR009081 PP-bd_ACP # InterPro IPR010071 AA_adenyl_domain # InterPro IPR020802 PKS_thioesterase # InterPro IPR020806 PKS_PP-bd # InterPro IPR020845 AMP-binding_CS # InterPro IPR029058 AB_hydrolase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01008 Polyketide biosynthesis proteins # KEGG_Pathway ko01053 Biosynthesis of siderophore group nonribosomal peptides # Organism ENTF_ECOLI Escherichia coli (strain K12) # PATHWAY ENTF_ECOLI Siderophore biosynthesis; enterobactin biosynthesis. # PATRIC 32116346 VBIEscCol129921_0613 # PDB 2ROQ NMR; -; A=960-1293 # PDB 3TEJ X-ray; 1.90 A; A/B=965-1293 # PDB 5JA1 X-ray; 3.00 A; A=1-1293 # PDB 5JA2 X-ray; 3.00 A; A=1-1293 # PDB 5T3D X-ray; 2.80 A; A=1-1293 # PIR H64791 YGECEF # PROSITE PS00012 PHOSPHOPANTETHEINE # PROSITE PS00455 AMP_BINDING # PROSITE PS50075 ACP_DOMAIN # PTM ENTF_ECOLI 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-EntF by EntD. Holo-EntF so formed is then acylated with seryl-AMP. # Pfam PF00501 AMP-binding # Pfam PF00550 PP-binding # Pfam PF00668 Condensation # Pfam PF00975 Thioesterase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ENTF_ECOLI Enterobactin synthase component F # RefSeq NP_415118 NC_000913.3 # RefSeq WP_000077805 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40785.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ATP-dependent AMP-binding enzyme family. EntF subfamily. {ECO 0000305}. # SIMILARITY Contains 1 acyl carrier domain. {ECO:0000255|PROSITE- ProRule PRU00258}. # SMART SM00823 PKS_PP # SMART SM00824 PKS_TE # SUBUNIT ENTF_ECOLI EntB, EntD, EntE, and EntF form a multienzyme complex called enterobactin synthase. EntF acts as a catalytic monomer. # SUPFAM SSF47336 SSF47336 # SUPFAM SSF53474 SSF53474 # TIGRFAMs TIGR01733 AA-adenyl-dom # eggNOG COG1020 LUCA # eggNOG COG3319 LUCA # eggNOG ENOG4105C0W Bacteria BLAST swissprot:ENTF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ENTF_ECOLI BioCyc ECOL316407:JW0578-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0578-MONOMER BioCyc EcoCyc:ENTF-MONOMER http://biocyc.org/getid?id=EcoCyc:ENTF-MONOMER BioCyc MetaCyc:ENTF-MONOMER http://biocyc.org/getid?id=MetaCyc:ENTF-MONOMER COG COG1020 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1020 COG COG3319 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3319 DIP DIP-9516N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9516N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1021/bi00225a027 http://dx.doi.org/10.1021/bi00225a027 DOI 10.1021/bi9726584 http://dx.doi.org/10.1021/bi9726584 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.7.- http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J04216 http://www.ebi.ac.uk/ena/data/view/J04216 EMBL M17354 http://www.ebi.ac.uk/ena/data/view/M17354 EMBL M60177 http://www.ebi.ac.uk/ena/data/view/M60177 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 ENZYME 2.7.7.- http://enzyme.expasy.org/EC/2.7.7.- EchoBASE EB0260 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0260 EcoGene EG10264 http://www.ecogene.org/geneInfo.php?eg_id=EG10264 EnsemblBacteria AAC73687 http://www.ensemblgenomes.org/id/AAC73687 EnsemblBacteria AAC73687 http://www.ensemblgenomes.org/id/AAC73687 EnsemblBacteria BAE76341 http://www.ensemblgenomes.org/id/BAE76341 EnsemblBacteria BAE76341 http://www.ensemblgenomes.org/id/BAE76341 EnsemblBacteria BAE76341 http://www.ensemblgenomes.org/id/BAE76341 EnsemblBacteria b0586 http://www.ensemblgenomes.org/id/b0586 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0009366 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009366 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GO_function GO:0016788 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016788 GO_function GO:0031177 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031177 GO_function GO:0047527 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047527 GO_process GO:0009239 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009239 GO_process GO:0043041 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043041 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0019748 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019748 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 1.10.1200.10 http://www.cathdb.info/version/latest/superfamily/1.10.1200.10 Gene3D 3.40.50.1820 http://www.cathdb.info/version/latest/superfamily/3.40.50.1820 GeneID 945184 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945184 HOGENOM HOG000229993 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000229993&db=HOGENOM6 InParanoid P11454 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P11454 IntAct P11454 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P11454* IntEnz 2.7.7 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7 InterPro IPR000873 http://www.ebi.ac.uk/interpro/entry/IPR000873 InterPro IPR001031 http://www.ebi.ac.uk/interpro/entry/IPR001031 InterPro IPR001242 http://www.ebi.ac.uk/interpro/entry/IPR001242 InterPro IPR006162 http://www.ebi.ac.uk/interpro/entry/IPR006162 InterPro IPR009081 http://www.ebi.ac.uk/interpro/entry/IPR009081 InterPro IPR010071 http://www.ebi.ac.uk/interpro/entry/IPR010071 InterPro IPR020802 http://www.ebi.ac.uk/interpro/entry/IPR020802 InterPro IPR020806 http://www.ebi.ac.uk/interpro/entry/IPR020806 InterPro IPR020845 http://www.ebi.ac.uk/interpro/entry/IPR020845 InterPro IPR029058 http://www.ebi.ac.uk/interpro/entry/IPR029058 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01008 http://www.genome.jp/dbget-bin/www_bget?ko01008 KEGG_Gene ecj:JW0578 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0578 KEGG_Gene eco:b0586 http://www.genome.jp/dbget-bin/www_bget?eco:b0586 KEGG_Orthology KO:K02364 http://www.genome.jp/dbget-bin/www_bget?KO:K02364 KEGG_Pathway ko01053 http://www.genome.jp/kegg-bin/show_pathway?ko01053 OMA FSVLARY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FSVLARY PDB 2ROQ http://www.ebi.ac.uk/pdbe-srv/view/entry/2ROQ PDB 3TEJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3TEJ PDB 5JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JA1 PDB 5JA2 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JA2 PDB 5T3D http://www.ebi.ac.uk/pdbe-srv/view/entry/5T3D PDBsum 2ROQ http://www.ebi.ac.uk/pdbsum/2ROQ PDBsum 3TEJ http://www.ebi.ac.uk/pdbsum/3TEJ PDBsum 5JA1 http://www.ebi.ac.uk/pdbsum/5JA1 PDBsum 5JA2 http://www.ebi.ac.uk/pdbsum/5JA2 PDBsum 5T3D http://www.ebi.ac.uk/pdbsum/5T3D PROSITE PS00012 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00012 PROSITE PS00455 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00455 PROSITE PS50075 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50075 PSORT swissprot:ENTF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ENTF_ECOLI PSORT-B swissprot:ENTF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ENTF_ECOLI PSORT2 swissprot:ENTF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ENTF_ECOLI Pfam PF00501 http://pfam.xfam.org/family/PF00501 Pfam PF00550 http://pfam.xfam.org/family/PF00550 Pfam PF00668 http://pfam.xfam.org/family/PF00668 Pfam PF00975 http://pfam.xfam.org/family/PF00975 Phobius swissprot:ENTF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ENTF_ECOLI PhylomeDB P11454 http://phylomedb.org/?seqid=P11454 ProteinModelPortal P11454 http://www.proteinmodelportal.org/query/uniprot/P11454 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1826089 http://www.ncbi.nlm.nih.gov/pubmed/1826089 PubMed 2974033 http://www.ncbi.nlm.nih.gov/pubmed/2974033 PubMed 3040679 http://www.ncbi.nlm.nih.gov/pubmed/3040679 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9485415 http://www.ncbi.nlm.nih.gov/pubmed/9485415 RefSeq NP_415118 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415118 RefSeq WP_000077805 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000077805 SMART SM00823 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00823 SMART SM00824 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00824 SMR P11454 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P11454 STRING 511145.b0586 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0586&targetmode=cogs STRING COG1020 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1020&targetmode=cogs STRING COG3319 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3319&targetmode=cogs SUPFAM SSF47336 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47336 SUPFAM SSF53474 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53474 TIGRFAMs TIGR01733 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01733 UniProtKB ENTF_ECOLI http://www.uniprot.org/uniprot/ENTF_ECOLI UniProtKB-AC P11454 http://www.uniprot.org/uniprot/P11454 charge swissprot:ENTF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ENTF_ECOLI eggNOG COG1020 http://eggnogapi.embl.de/nog_data/html/tree/COG1020 eggNOG COG3319 http://eggnogapi.embl.de/nog_data/html/tree/COG3319 eggNOG ENOG4105C0W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C0W epestfind swissprot:ENTF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ENTF_ECOLI garnier swissprot:ENTF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ENTF_ECOLI helixturnhelix swissprot:ENTF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ENTF_ECOLI hmoment swissprot:ENTF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ENTF_ECOLI iep swissprot:ENTF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ENTF_ECOLI inforesidue swissprot:ENTF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ENTF_ECOLI octanol swissprot:ENTF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ENTF_ECOLI pepcoil swissprot:ENTF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ENTF_ECOLI pepdigest swissprot:ENTF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ENTF_ECOLI pepinfo swissprot:ENTF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ENTF_ECOLI pepnet swissprot:ENTF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ENTF_ECOLI pepstats swissprot:ENTF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ENTF_ECOLI pepwheel swissprot:ENTF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ENTF_ECOLI pepwindow swissprot:ENTF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ENTF_ECOLI sigcleave swissprot:ENTF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ENTF_ECOLI ## Database ID URL or Descriptions # BioGrid 4262421 6 # EcoGene EG10992 tdcR # FUNCTION TDCR_ECOLI Probable trans-acting positive activator for the tdc operon. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Organism TDCR_ECOLI Escherichia coli (strain K12) # PATRIC 32121654 VBIEscCol129921_3213 # PIR D65101 BVECTD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TDCR_ECOLI Threonine dehydratase operon activator protein # RefSeq NP_417589 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA57923.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA32591.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=CAA34464.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; BLAST swissprot:TDCR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TDCR_ECOLI BioCyc ECOL316407:JW5525-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5525-MONOMER BioCyc EcoCyc:PD03292 http://biocyc.org/getid?id=EcoCyc:PD03292 DOI 10.1007/BF00332418 http://dx.doi.org/10.1007/BF00332418 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/17.10.3994 http://dx.doi.org/10.1093/nar/17.10.3994 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X14430 http://www.ebi.ac.uk/ena/data/view/X14430 EMBL X16445 http://www.ebi.ac.uk/ena/data/view/X16445 EchoBASE EB0985 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0985 EcoGene EG10992 http://www.ecogene.org/geneInfo.php?eg_id=EG10992 EnsemblBacteria AAC76154 http://www.ensemblgenomes.org/id/AAC76154 EnsemblBacteria AAC76154 http://www.ensemblgenomes.org/id/AAC76154 EnsemblBacteria BAE77168 http://www.ensemblgenomes.org/id/BAE77168 EnsemblBacteria BAE77168 http://www.ensemblgenomes.org/id/BAE77168 EnsemblBacteria BAE77168 http://www.ensemblgenomes.org/id/BAE77168 EnsemblBacteria b3119 http://www.ensemblgenomes.org/id/b3119 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 944907 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944907 HOGENOM HOG000009595 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009595&db=HOGENOM6 KEGG_Gene ecj:JW5525 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5525 KEGG_Gene eco:b3119 http://www.genome.jp/dbget-bin/www_bget?eco:b3119 KEGG_Orthology KO:K07591 http://www.genome.jp/dbget-bin/www_bget?KO:K07591 OMA YVKISNT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YVKISNT PSORT swissprot:TDCR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TDCR_ECOLI PSORT-B swissprot:TDCR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TDCR_ECOLI PSORT2 swissprot:TDCR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TDCR_ECOLI Phobius swissprot:TDCR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TDCR_ECOLI ProteinModelPortal P11866 http://www.proteinmodelportal.org/query/uniprot/P11866 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2573820 http://www.ncbi.nlm.nih.gov/pubmed/2573820 PubMed 2660107 http://www.ncbi.nlm.nih.gov/pubmed/2660107 PubMed 7928991 http://www.ncbi.nlm.nih.gov/pubmed/7928991 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417589 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417589 STRING 511145.b3119 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3119&targetmode=cogs UniProtKB TDCR_ECOLI http://www.uniprot.org/uniprot/TDCR_ECOLI UniProtKB-AC P11866 http://www.uniprot.org/uniprot/P11866 charge swissprot:TDCR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TDCR_ECOLI epestfind swissprot:TDCR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TDCR_ECOLI garnier swissprot:TDCR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TDCR_ECOLI helixturnhelix swissprot:TDCR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TDCR_ECOLI hmoment swissprot:TDCR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TDCR_ECOLI iep swissprot:TDCR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TDCR_ECOLI inforesidue swissprot:TDCR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TDCR_ECOLI octanol swissprot:TDCR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TDCR_ECOLI pepcoil swissprot:TDCR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TDCR_ECOLI pepdigest swissprot:TDCR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TDCR_ECOLI pepinfo swissprot:TDCR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TDCR_ECOLI pepnet swissprot:TDCR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TDCR_ECOLI pepstats swissprot:TDCR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TDCR_ECOLI pepwheel swissprot:TDCR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TDCR_ECOLI pepwindow swissprot:TDCR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TDCR_ECOLI sigcleave swissprot:TDCR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TDCR_ECOLI ## Database ID URL or Descriptions # BioGrid 4260136 255 # CDD cd06261 TM_PBP2 # EcoGene EG20255 sapB # FUNCTION SAPB_ECOLI Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0022857 transmembrane transporter activity; IBA:GO_Central. # GO_function GO:0042936 dipeptide transporter activity; IBA:GO_Central. # GO_process GO:0015031 protein transport; IEA:UniProtKB-KW. # GO_process GO:0055085 transmembrane transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # Gene3D 1.10.3720.10 -; 2. # InterPro IPR000515 MetI-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00324 Dipeptide transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism SAPB_ECOLI Escherichia coli (strain K12) # PATRIC 32117856 VBIEscCol129921_1348 # PIR H64877 H64877 # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SAPB_ECOLI Peptide transport system permease protein SapB # RefSeq NP_415809 NC_000913.3 # RefSeq WP_000583277 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION SAPB_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF161098 SSF161098; 2 # TCDB 3.A.1.5.42 the atp-binding cassette (abc) superfamily # eggNOG COG4168 LUCA # eggNOG ENOG4108I5W Bacteria BLAST swissprot:SAPB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SAPB_ECOLI BioCyc ECOL316407:JW1286-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1286-MONOMER BioCyc EcoCyc:SAPB-MONOMER http://biocyc.org/getid?id=EcoCyc:SAPB-MONOMER COG COG0601 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0601 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X97282 http://www.ebi.ac.uk/ena/data/view/X97282 EchoBASE EB4156 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4156 EcoGene EG20255 http://www.ecogene.org/geneInfo.php?eg_id=EG20255 EnsemblBacteria AAC74375 http://www.ensemblgenomes.org/id/AAC74375 EnsemblBacteria AAC74375 http://www.ensemblgenomes.org/id/AAC74375 EnsemblBacteria BAA14854 http://www.ensemblgenomes.org/id/BAA14854 EnsemblBacteria BAA14854 http://www.ensemblgenomes.org/id/BAA14854 EnsemblBacteria BAA14854 http://www.ensemblgenomes.org/id/BAA14854 EnsemblBacteria b1293 http://www.ensemblgenomes.org/id/b1293 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GO_function GO:0042936 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042936 GO_process GO:0015031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 946191 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946191 HOGENOM HOG000170242 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000170242&db=HOGENOM6 InParanoid P0AGH3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGH3 InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1286 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1286 KEGG_Gene eco:b1293 http://www.genome.jp/dbget-bin/www_bget?eco:b1293 KEGG_Orthology KO:K12369 http://www.genome.jp/dbget-bin/www_bget?KO:K12369 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA VPQNEIQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VPQNEIQ PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:SAPB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SAPB_ECOLI PSORT-B swissprot:SAPB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SAPB_ECOLI PSORT2 swissprot:SAPB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SAPB_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Phobius swissprot:SAPB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SAPB_ECOLI PhylomeDB P0AGH3 http://phylomedb.org/?seqid=P0AGH3 ProteinModelPortal P0AGH3 http://www.proteinmodelportal.org/query/uniprot/P0AGH3 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415809 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415809 RefSeq WP_000583277 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000583277 STRING 511145.b1293 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1293&targetmode=cogs STRING COG0601 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0601&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.5.42 http://www.tcdb.org/search/result.php?tc=3.A.1.5.42 UniProtKB SAPB_ECOLI http://www.uniprot.org/uniprot/SAPB_ECOLI UniProtKB-AC P0AGH3 http://www.uniprot.org/uniprot/P0AGH3 charge swissprot:SAPB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SAPB_ECOLI eggNOG COG4168 http://eggnogapi.embl.de/nog_data/html/tree/COG4168 eggNOG ENOG4108I5W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108I5W epestfind swissprot:SAPB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SAPB_ECOLI garnier swissprot:SAPB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SAPB_ECOLI helixturnhelix swissprot:SAPB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SAPB_ECOLI hmoment swissprot:SAPB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SAPB_ECOLI iep swissprot:SAPB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SAPB_ECOLI inforesidue swissprot:SAPB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SAPB_ECOLI octanol swissprot:SAPB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SAPB_ECOLI pepcoil swissprot:SAPB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SAPB_ECOLI pepdigest swissprot:SAPB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SAPB_ECOLI pepinfo swissprot:SAPB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SAPB_ECOLI pepnet swissprot:SAPB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SAPB_ECOLI pepstats swissprot:SAPB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SAPB_ECOLI pepwheel swissprot:SAPB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SAPB_ECOLI pepwindow swissprot:SAPB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SAPB_ECOLI sigcleave swissprot:SAPB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SAPB_ECOLI ## Database ID URL or Descriptions # AltName CATE_ECOLI Hydroxyperoxidase II # BioGrid 4263059 28 # CATALYTIC ACTIVITY 2 H(2)O(2) = O(2) + 2 H(2)O. {ECO:0000255|PROSITE-ProRule PRU10013}. # COFACTOR Name=heme; Xref=ChEBI:CHEBI 30413; # EcoGene EG10509 katE # FUNCTION CATE_ECOLI Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0004096 catalase activity; IMP:CACAO. # GO_function GO:0005506 iron ion binding; IDA:EcoliWiki. # GO_function GO:0020037 heme binding; IDA:EcoliWiki. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0006972 hyperosmotic response; IEP:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0006979 response to oxidative stress; IMP:EcoliWiki. # GO_process GO:0042542 response to hydrogen peroxide; IBA:GO_Central. # GO_process GO:0042744 hydrogen peroxide catabolic process; IMP:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009056 catabolic process # Gene3D 2.40.180.10 -; 1. # Gene3D 3.40.50.880 -; 1. # INDUCTION CATE_ECOLI By entry into stationary phase. # INTERACTION CATE_ECOLI Self; NbExp=2; IntAct=EBI-549879, EBI-549879; # IntAct P21179 11 # InterPro IPR002226 Catalase_haem_BS # InterPro IPR010582 Catalase_immune_responsive # InterPro IPR011614 Catalase_core # InterPro IPR018028 Catalase # InterPro IPR020835 Catalase-like_dom # InterPro IPR024708 Catalase_AS # InterPro IPR024712 Catalase_clade2 # InterPro IPR029062 Class_I_gatase-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00380 Tryptophan metabolism # KEGG_Pathway ko00630 Glyoxylate and dicarboxylate metabolism # KEGG_Pathway ko00680 Methane metabolism # KEGG_Pathway ko04146 Peroxisome # KEGG_Pathway ko05014 Amyotrophic lateral sclerosis (ALS) # Organism CATE_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11465 PTHR11465 # PATRIC 32118771 VBIEscCol129921_1803 # PDB 1CF9 X-ray; 1.80 A; A/B/C/D=1-753 # PDB 1GG9 X-ray; 1.89 A; A/B/C/D=1-753 # PDB 1GGE X-ray; 1.89 A; A/B/C/D=1-753 # PDB 1GGF X-ray; 2.28 A; A/B/C/D=1-753 # PDB 1GGH X-ray; 2.15 A; A/B/C/D=1-753 # PDB 1GGJ X-ray; 1.92 A; A/B/C/D=1-753 # PDB 1GGK X-ray; 2.26 A; A/B/C/D=1-753 # PDB 1IPH X-ray; 2.80 A; A/B/C/D=1-753 # PDB 1P7Y X-ray; 2.40 A; A/B/C/D=1-753 # PDB 1P7Z X-ray; 2.21 A; A/B/C/D=1-753 # PDB 1P80 X-ray; 1.65 A; A/B/C/D=1-753 # PDB 1P81 X-ray; 1.81 A; A/B/C/D=1-753 # PDB 1QF7 X-ray; 2.20 A; A/B/C/D=1-753 # PDB 1QWS X-ray; 1.90 A; A/B/C/D=1-753 # PDB 1YE9 X-ray; 2.80 A; A/B/C/D/I/J/K/L=75-300, E/F/G/H/M/N/O/P=309-567 # PDB 3P9P X-ray; 1.50 A; A/B/C/D=1-753 # PDB 3P9Q X-ray; 1.48 A; A/B/C/D=1-753 # PDB 3P9R X-ray; 1.90 A; A/B/C/D=1-753 # PDB 3P9S X-ray; 1.90 A; A/B/C/D=1-753 # PDB 3PQ2 X-ray; 1.79 A; A/B/C/D=1-753 # PDB 3PQ3 X-ray; 1.79 A; A/B/C/D=1-753 # PDB 3PQ4 X-ray; 1.79 A; A/B/C/D=1-753 # PDB 3PQ5 X-ray; 1.80 A; A/B/C/D=1-753 # PDB 3PQ6 X-ray; 1.80 A; A/B/C/D=1-753 # PDB 3PQ7 X-ray; 1.80 A; A/B/C/D=1-753 # PDB 3PQ8 X-ray; 1.80 A; A/B/C/D=1-753 # PDB 3TTT X-ray; 1.58 A; A/B/C/D=1-753 # PDB 3TTU X-ray; 1.89 A; A/B/C/D=1-753 # PDB 3TTV X-ray; 1.45 A; A/B/C/D=1-753 # PDB 3TTW X-ray; 1.62 A; A/B/C/D=1-753 # PDB 3TTX X-ray; 1.74 A; A/B/C/D=1-753 # PDB 3VU3 X-ray; 2.85 A; A=1-753 # PDB 4BFL X-ray; 1.64 A; A/B/C/D=1-753 # PDB 4ENP X-ray; 1.50 A; A/B/C/D=1-753 # PDB 4ENQ X-ray; 1.90 A; A/B/C/D=1-753 # PDB 4ENR X-ray; 1.60 A; A/B/C/D=1-753 # PDB 4ENS X-ray; 1.60 A; A/B/C/D=1-753 # PDB 4ENT X-ray; 1.70 A; A/B/C/D=1-753 # PDB 4ENU X-ray; 1.70 A; A/B/C/D=1-753 # PDB 4ENV X-ray; 1.70 A; A/B/C/D=1-753 # PDB 4ENW X-ray; 1.90 A; A/B/C/D=1-753 # PDB 5BV2 X-ray; 1.53 A; P/Q/R/S=1-753 # PIR A39129 A39129 # PIRSF PIRSF038927 Catalase_clade2 # PRINTS PR00067 CATALASE # PROSITE PS00437 CATALASE_1 # PROSITE PS00438 CATALASE_2 # PROSITE PS51402 CATALASE_3 # PeroxiBase 5321 EcoKat05 # Pfam PF00199 Catalase # Pfam PF06628 Catalase-rel # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CATE_ECOLI Catalase HPII # RefSeq WP_000077872 NZ_LN832404.1 # RefSeq YP_025308 NC_000913.3 # SIMILARITY Belongs to the catalase family. HPII subfamily. {ECO 0000305}. # SMART SM01060 Catalase # SUBCELLULAR LOCATION CATE_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT CATE_ECOLI Homotetramer. # SUPFAM SSF52317 SSF52317 # SUPFAM SSF56634 SSF56634 # eggNOG COG0753 LUCA # eggNOG ENOG4105CH6 Bacteria BLAST swissprot:CATE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CATE_ECOLI BioCyc ECOL316407:JW1721-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1721-MONOMER BioCyc EcoCyc:HYDROPEROXIDII-MONOMER http://biocyc.org/getid?id=EcoCyc:HYDROPEROXIDII-MONOMER BioCyc MetaCyc:HYDROPEROXIDII-MONOMER http://biocyc.org/getid?id=MetaCyc:HYDROPEROXIDII-MONOMER COG COG0753 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0753 DIP DIP-10052N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10052N DOI 10.1002/pro.5560060507 http://dx.doi.org/10.1002/pro.5560060507 DOI 10.1002/prot.1092 http://dx.doi.org/10.1002/prot.1092 DOI 10.1016/S0969-2126(01)00182-4 http://dx.doi.org/10.1016/S0969-2126(01)00182-4 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1110/ps.8.3.490 http://dx.doi.org/10.1110/ps.8.3.490 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.11.1.6 http://www.genome.jp/dbget-bin/www_bget?EC:1.11.1.6 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M55161 http://www.ebi.ac.uk/ena/data/view/M55161 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.11.1.6 http://enzyme.expasy.org/EC/1.11.1.6 EchoBASE EB0504 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0504 EcoGene EG10509 http://www.ecogene.org/geneInfo.php?eg_id=EG10509 EnsemblBacteria AAT48137 http://www.ensemblgenomes.org/id/AAT48137 EnsemblBacteria AAT48137 http://www.ensemblgenomes.org/id/AAT48137 EnsemblBacteria BAA15513 http://www.ensemblgenomes.org/id/BAA15513 EnsemblBacteria BAA15513 http://www.ensemblgenomes.org/id/BAA15513 EnsemblBacteria BAA15513 http://www.ensemblgenomes.org/id/BAA15513 EnsemblBacteria b1732 http://www.ensemblgenomes.org/id/b1732 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004096 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004096 GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0020037 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0020037 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0006972 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006972 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0006979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979 GO_process GO:0042542 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042542 GO_process GO:0042744 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042744 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 2.40.180.10 http://www.cathdb.info/version/latest/superfamily/2.40.180.10 Gene3D 3.40.50.880 http://www.cathdb.info/version/latest/superfamily/3.40.50.880 GeneID 946234 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946234 HOGENOM HOG000087851 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000087851&db=HOGENOM6 InParanoid P21179 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P21179 IntAct P21179 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P21179* IntEnz 1.11.1.6 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.11.1.6 InterPro IPR002226 http://www.ebi.ac.uk/interpro/entry/IPR002226 InterPro IPR010582 http://www.ebi.ac.uk/interpro/entry/IPR010582 InterPro IPR011614 http://www.ebi.ac.uk/interpro/entry/IPR011614 InterPro IPR018028 http://www.ebi.ac.uk/interpro/entry/IPR018028 InterPro IPR020835 http://www.ebi.ac.uk/interpro/entry/IPR020835 InterPro IPR024708 http://www.ebi.ac.uk/interpro/entry/IPR024708 InterPro IPR024712 http://www.ebi.ac.uk/interpro/entry/IPR024712 InterPro IPR029062 http://www.ebi.ac.uk/interpro/entry/IPR029062 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1721 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1721 KEGG_Gene eco:b1732 http://www.genome.jp/dbget-bin/www_bget?eco:b1732 KEGG_Orthology KO:K03781 http://www.genome.jp/dbget-bin/www_bget?KO:K03781 KEGG_Pathway ko00380 http://www.genome.jp/kegg-bin/show_pathway?ko00380 KEGG_Pathway ko00630 http://www.genome.jp/kegg-bin/show_pathway?ko00630 KEGG_Pathway ko00680 http://www.genome.jp/kegg-bin/show_pathway?ko00680 KEGG_Pathway ko04146 http://www.genome.jp/kegg-bin/show_pathway?ko04146 KEGG_Pathway ko05014 http://www.genome.jp/kegg-bin/show_pathway?ko05014 KEGG_Reaction rn:R00009 http://www.genome.jp/dbget-bin/www_bget?rn:R00009 KEGG_Reaction rn:R00602 http://www.genome.jp/dbget-bin/www_bget?rn:R00602 KEGG_Reaction rn:R02670 http://www.genome.jp/dbget-bin/www_bget?rn:R02670 MINT MINT-1247982 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1247982 OMA HNEIPTG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HNEIPTG PANTHER PTHR11465 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11465 PDB 1CF9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1CF9 PDB 1GG9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1GG9 PDB 1GGE http://www.ebi.ac.uk/pdbe-srv/view/entry/1GGE PDB 1GGF http://www.ebi.ac.uk/pdbe-srv/view/entry/1GGF PDB 1GGH http://www.ebi.ac.uk/pdbe-srv/view/entry/1GGH PDB 1GGJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1GGJ PDB 1GGK http://www.ebi.ac.uk/pdbe-srv/view/entry/1GGK PDB 1IPH http://www.ebi.ac.uk/pdbe-srv/view/entry/1IPH PDB 1P7Y http://www.ebi.ac.uk/pdbe-srv/view/entry/1P7Y PDB 1P7Z http://www.ebi.ac.uk/pdbe-srv/view/entry/1P7Z PDB 1P80 http://www.ebi.ac.uk/pdbe-srv/view/entry/1P80 PDB 1P81 http://www.ebi.ac.uk/pdbe-srv/view/entry/1P81 PDB 1QF7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1QF7 PDB 1QWS http://www.ebi.ac.uk/pdbe-srv/view/entry/1QWS PDB 1YE9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1YE9 PDB 3P9P http://www.ebi.ac.uk/pdbe-srv/view/entry/3P9P PDB 3P9Q http://www.ebi.ac.uk/pdbe-srv/view/entry/3P9Q PDB 3P9R http://www.ebi.ac.uk/pdbe-srv/view/entry/3P9R PDB 3P9S http://www.ebi.ac.uk/pdbe-srv/view/entry/3P9S PDB 3PQ2 http://www.ebi.ac.uk/pdbe-srv/view/entry/3PQ2 PDB 3PQ3 http://www.ebi.ac.uk/pdbe-srv/view/entry/3PQ3 PDB 3PQ4 http://www.ebi.ac.uk/pdbe-srv/view/entry/3PQ4 PDB 3PQ5 http://www.ebi.ac.uk/pdbe-srv/view/entry/3PQ5 PDB 3PQ6 http://www.ebi.ac.uk/pdbe-srv/view/entry/3PQ6 PDB 3PQ7 http://www.ebi.ac.uk/pdbe-srv/view/entry/3PQ7 PDB 3PQ8 http://www.ebi.ac.uk/pdbe-srv/view/entry/3PQ8 PDB 3TTT http://www.ebi.ac.uk/pdbe-srv/view/entry/3TTT PDB 3TTU http://www.ebi.ac.uk/pdbe-srv/view/entry/3TTU PDB 3TTV http://www.ebi.ac.uk/pdbe-srv/view/entry/3TTV PDB 3TTW http://www.ebi.ac.uk/pdbe-srv/view/entry/3TTW PDB 3TTX http://www.ebi.ac.uk/pdbe-srv/view/entry/3TTX PDB 3VU3 http://www.ebi.ac.uk/pdbe-srv/view/entry/3VU3 PDB 4BFL http://www.ebi.ac.uk/pdbe-srv/view/entry/4BFL PDB 4ENP http://www.ebi.ac.uk/pdbe-srv/view/entry/4ENP PDB 4ENQ http://www.ebi.ac.uk/pdbe-srv/view/entry/4ENQ PDB 4ENR http://www.ebi.ac.uk/pdbe-srv/view/entry/4ENR PDB 4ENS http://www.ebi.ac.uk/pdbe-srv/view/entry/4ENS PDB 4ENT http://www.ebi.ac.uk/pdbe-srv/view/entry/4ENT PDB 4ENU http://www.ebi.ac.uk/pdbe-srv/view/entry/4ENU PDB 4ENV http://www.ebi.ac.uk/pdbe-srv/view/entry/4ENV PDB 4ENW http://www.ebi.ac.uk/pdbe-srv/view/entry/4ENW PDB 5BV2 http://www.ebi.ac.uk/pdbe-srv/view/entry/5BV2 PDBsum 1CF9 http://www.ebi.ac.uk/pdbsum/1CF9 PDBsum 1GG9 http://www.ebi.ac.uk/pdbsum/1GG9 PDBsum 1GGE http://www.ebi.ac.uk/pdbsum/1GGE PDBsum 1GGF http://www.ebi.ac.uk/pdbsum/1GGF PDBsum 1GGH http://www.ebi.ac.uk/pdbsum/1GGH PDBsum 1GGJ http://www.ebi.ac.uk/pdbsum/1GGJ PDBsum 1GGK http://www.ebi.ac.uk/pdbsum/1GGK PDBsum 1IPH http://www.ebi.ac.uk/pdbsum/1IPH PDBsum 1P7Y http://www.ebi.ac.uk/pdbsum/1P7Y PDBsum 1P7Z http://www.ebi.ac.uk/pdbsum/1P7Z PDBsum 1P80 http://www.ebi.ac.uk/pdbsum/1P80 PDBsum 1P81 http://www.ebi.ac.uk/pdbsum/1P81 PDBsum 1QF7 http://www.ebi.ac.uk/pdbsum/1QF7 PDBsum 1QWS http://www.ebi.ac.uk/pdbsum/1QWS PDBsum 1YE9 http://www.ebi.ac.uk/pdbsum/1YE9 PDBsum 3P9P http://www.ebi.ac.uk/pdbsum/3P9P PDBsum 3P9Q http://www.ebi.ac.uk/pdbsum/3P9Q PDBsum 3P9R http://www.ebi.ac.uk/pdbsum/3P9R PDBsum 3P9S http://www.ebi.ac.uk/pdbsum/3P9S PDBsum 3PQ2 http://www.ebi.ac.uk/pdbsum/3PQ2 PDBsum 3PQ3 http://www.ebi.ac.uk/pdbsum/3PQ3 PDBsum 3PQ4 http://www.ebi.ac.uk/pdbsum/3PQ4 PDBsum 3PQ5 http://www.ebi.ac.uk/pdbsum/3PQ5 PDBsum 3PQ6 http://www.ebi.ac.uk/pdbsum/3PQ6 PDBsum 3PQ7 http://www.ebi.ac.uk/pdbsum/3PQ7 PDBsum 3PQ8 http://www.ebi.ac.uk/pdbsum/3PQ8 PDBsum 3TTT http://www.ebi.ac.uk/pdbsum/3TTT PDBsum 3TTU http://www.ebi.ac.uk/pdbsum/3TTU PDBsum 3TTV http://www.ebi.ac.uk/pdbsum/3TTV PDBsum 3TTW http://www.ebi.ac.uk/pdbsum/3TTW PDBsum 3TTX http://www.ebi.ac.uk/pdbsum/3TTX PDBsum 3VU3 http://www.ebi.ac.uk/pdbsum/3VU3 PDBsum 4BFL http://www.ebi.ac.uk/pdbsum/4BFL PDBsum 4ENP http://www.ebi.ac.uk/pdbsum/4ENP PDBsum 4ENQ http://www.ebi.ac.uk/pdbsum/4ENQ PDBsum 4ENR http://www.ebi.ac.uk/pdbsum/4ENR PDBsum 4ENS http://www.ebi.ac.uk/pdbsum/4ENS PDBsum 4ENT http://www.ebi.ac.uk/pdbsum/4ENT PDBsum 4ENU http://www.ebi.ac.uk/pdbsum/4ENU PDBsum 4ENV http://www.ebi.ac.uk/pdbsum/4ENV PDBsum 4ENW http://www.ebi.ac.uk/pdbsum/4ENW PDBsum 5BV2 http://www.ebi.ac.uk/pdbsum/5BV2 PRINTS PR00067 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00067 PROSITE PS00437 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00437 PROSITE PS00438 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00438 PROSITE PS51402 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51402 PSORT swissprot:CATE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CATE_ECOLI PSORT-B swissprot:CATE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CATE_ECOLI PSORT2 swissprot:CATE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CATE_ECOLI PeroxiBase 5321 http://peroxibase.toulouse.inra.fr/listing.php?action=view&id=5321 Pfam PF00199 http://pfam.xfam.org/family/PF00199 Pfam PF06628 http://pfam.xfam.org/family/PF06628 Phobius swissprot:CATE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CATE_ECOLI PhylomeDB P21179 http://phylomedb.org/?seqid=P21179 ProteinModelPortal P21179 http://www.proteinmodelportal.org/query/uniprot/P21179 PubMed 10091651 http://www.ncbi.nlm.nih.gov/pubmed/10091651 PubMed 11455600 http://www.ncbi.nlm.nih.gov/pubmed/11455600 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1987146 http://www.ncbi.nlm.nih.gov/pubmed/1987146 PubMed 7663946 http://www.ncbi.nlm.nih.gov/pubmed/7663946 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9144772 http://www.ncbi.nlm.nih.gov/pubmed/9144772 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000077872 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000077872 RefSeq YP_025308 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_025308 SMART SM01060 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01060 SMR P21179 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P21179 STRING 511145.b1732 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1732&targetmode=cogs STRING COG0753 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0753&targetmode=cogs SUPFAM SSF52317 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52317 SUPFAM SSF56634 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56634 SWISS-2DPAGE P21179 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P21179 UniProtKB CATE_ECOLI http://www.uniprot.org/uniprot/CATE_ECOLI UniProtKB-AC P21179 http://www.uniprot.org/uniprot/P21179 charge swissprot:CATE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CATE_ECOLI eggNOG COG0753 http://eggnogapi.embl.de/nog_data/html/tree/COG0753 eggNOG ENOG4105CH6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CH6 epestfind swissprot:CATE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CATE_ECOLI garnier swissprot:CATE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CATE_ECOLI helixturnhelix swissprot:CATE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CATE_ECOLI hmoment swissprot:CATE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CATE_ECOLI iep swissprot:CATE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CATE_ECOLI inforesidue swissprot:CATE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CATE_ECOLI octanol swissprot:CATE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CATE_ECOLI pepcoil swissprot:CATE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CATE_ECOLI pepdigest swissprot:CATE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CATE_ECOLI pepinfo swissprot:CATE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CATE_ECOLI pepnet swissprot:CATE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CATE_ECOLI pepstats swissprot:CATE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CATE_ECOLI pepwheel swissprot:CATE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CATE_ECOLI pepwindow swissprot:CATE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CATE_ECOLI sigcleave swissprot:CATE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CATE_ECOLI ## Database ID URL or Descriptions # AltName Adenosine aminohydrolase {ECO:0000255|HAMAP-Rule MF_00540} # BioGrid 4260251 7 # CATALYTIC ACTIVITY Adenosine + H(2)O = inosine + NH(3). {ECO:0000255|HAMAP-Rule MF_00540}. # CDD cd01320 ADA # COFACTOR ADD_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000255|HAMAP-Rule MF_00540}; Note=Binds 1 zinc ion per subunit. {ECO 0000255|HAMAP- Rule MF_00540}; # EcoGene EG10030 add # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004000 adenosine deaminase activity; IDA:EcoliWiki. # GO_function GO:0008270 zinc ion binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006154 adenosine catabolic process; IGI:EcoliWiki. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0009168 purine ribonucleoside monophosphate biosynthetic process; IGI:EcoliWiki. # GO_process GO:0015950 purine nucleotide interconversion; IGI:EcoliWiki. # GO_process GO:0032261 purine nucleotide salvage; IGI:EcoliWiki. # GO_process GO:0043103 hypoxanthine salvage; IGI:EcoliWiki. # GO_process GO:0046101 hypoxanthine biosynthetic process; IGI:EcoliWiki. # GO_process GO:0046103 inosine biosynthetic process; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # GOslim_process GO:0044281 small molecule metabolic process # HAMAP MF_00540 A_deaminase # IntAct P22333 15 # InterPro IPR001365 A/AMP_deaminase_dom # InterPro IPR006330 Ado/ade_deaminase # InterPro IPR006650 A/AMP_deam_AS # InterPro IPR028893 A_deaminase # InterPro IPR032466 Metal_Hydrolase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko05340 Primary immunodeficiency # Organism ADD_ECOLI Escherichia coli (strain K12) # PATRIC 32118548 VBIEscCol129921_1694 # PIR A64919 A64919 # PROSITE PS00485 A_DEAMINASE # Pfam PF00962 A_deaminase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Adenosine deaminase {ECO:0000255|HAMAP-Rule MF_00540} # RefSeq NP_416140 NC_000913.3 # RefSeq WP_000567490 NZ_LN832404.1 # SIMILARITY Belongs to the adenosine and AMP deaminases family. Adenosine deaminase subfamily. {ECO:0000255|HAMAP-Rule MF_00540}. # SUPFAM SSF51556 SSF51556 # TIGRFAMs TIGR01430 aden_deam # eggNOG COG1816 LUCA # eggNOG ENOG4105EKD Bacteria BLAST swissprot:ADD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ADD_ECOLI BioCyc ECOL316407:JW1615-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1615-MONOMER BioCyc EcoCyc:ADENODEAMIN-MONOMER http://biocyc.org/getid?id=EcoCyc:ADENODEAMIN-MONOMER BioCyc MetaCyc:ADENODEAMIN-MONOMER http://biocyc.org/getid?id=MetaCyc:ADENODEAMIN-MONOMER COG COG1816 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1816 DIP DIP-9056N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9056N DOI 10.1021/bi00222a033 http://dx.doi.org/10.1021/bi00222a033 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.5.4.4 {ECO:0000255|HAMAP-Rule:MF_00540} http://www.genome.jp/dbget-bin/www_bget?EC:3.5.4.4 {ECO:0000255|HAMAP-Rule:MF_00540} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M59033 http://www.ebi.ac.uk/ena/data/view/M59033 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.5.4.4 {ECO:0000255|HAMAP-Rule:MF_00540} http://enzyme.expasy.org/EC/3.5.4.4 {ECO:0000255|HAMAP-Rule:MF_00540} EchoBASE EB0029 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0029 EcoGene EG10030 http://www.ecogene.org/geneInfo.php?eg_id=EG10030 EnsemblBacteria AAC74695 http://www.ensemblgenomes.org/id/AAC74695 EnsemblBacteria AAC74695 http://www.ensemblgenomes.org/id/AAC74695 EnsemblBacteria BAA15374 http://www.ensemblgenomes.org/id/BAA15374 EnsemblBacteria BAA15374 http://www.ensemblgenomes.org/id/BAA15374 EnsemblBacteria BAA15374 http://www.ensemblgenomes.org/id/BAA15374 EnsemblBacteria b1623 http://www.ensemblgenomes.org/id/b1623 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004000 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004000 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_process GO:0006154 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006154 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0009168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009168 GO_process GO:0015950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015950 GO_process GO:0032261 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032261 GO_process GO:0043103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043103 GO_process GO:0046101 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046101 GO_process GO:0046103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046103 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 945851 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945851 HAMAP MF_00540 http://hamap.expasy.org/unirule/MF_00540 HOGENOM HOG000218815 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218815&db=HOGENOM6 InParanoid P22333 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P22333 IntAct P22333 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P22333* IntEnz 3.5.4.4 {ECO:0000255|HAMAP-Rule:MF_00540} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.4.4 {ECO:0000255|HAMAP-Rule:MF_00540} InterPro IPR001365 http://www.ebi.ac.uk/interpro/entry/IPR001365 InterPro IPR006330 http://www.ebi.ac.uk/interpro/entry/IPR006330 InterPro IPR006650 http://www.ebi.ac.uk/interpro/entry/IPR006650 InterPro IPR028893 http://www.ebi.ac.uk/interpro/entry/IPR028893 InterPro IPR032466 http://www.ebi.ac.uk/interpro/entry/IPR032466 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1615 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1615 KEGG_Gene eco:b1623 http://www.genome.jp/dbget-bin/www_bget?eco:b1623 KEGG_Orthology KO:K01488 http://www.genome.jp/dbget-bin/www_bget?KO:K01488 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko05340 http://www.genome.jp/kegg-bin/show_pathway?ko05340 KEGG_Reaction rn:R01560 http://www.genome.jp/dbget-bin/www_bget?rn:R01560 KEGG_Reaction rn:R02556 http://www.genome.jp/dbget-bin/www_bget?rn:R02556 MINT MINT-1298977 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1298977 OMA DWMVAVL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DWMVAVL PROSITE PS00485 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00485 PSORT swissprot:ADD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ADD_ECOLI PSORT-B swissprot:ADD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ADD_ECOLI PSORT2 swissprot:ADD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ADD_ECOLI Pfam PF00962 http://pfam.xfam.org/family/PF00962 Phobius swissprot:ADD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ADD_ECOLI PhylomeDB P22333 http://phylomedb.org/?seqid=P22333 ProteinModelPortal P22333 http://www.proteinmodelportal.org/query/uniprot/P22333 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1998686 http://www.ncbi.nlm.nih.gov/pubmed/1998686 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416140 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416140 RefSeq WP_000567490 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000567490 SMR P22333 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P22333 STRING 511145.b1623 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1623&targetmode=cogs STRING COG1816 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1816&targetmode=cogs SUPFAM SSF51556 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51556 TIGRFAMs TIGR01430 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01430 UniProtKB ADD_ECOLI http://www.uniprot.org/uniprot/ADD_ECOLI UniProtKB-AC P22333 http://www.uniprot.org/uniprot/P22333 charge swissprot:ADD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ADD_ECOLI eggNOG COG1816 http://eggnogapi.embl.de/nog_data/html/tree/COG1816 eggNOG ENOG4105EKD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EKD epestfind swissprot:ADD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ADD_ECOLI garnier swissprot:ADD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ADD_ECOLI helixturnhelix swissprot:ADD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ADD_ECOLI hmoment swissprot:ADD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ADD_ECOLI iep swissprot:ADD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ADD_ECOLI inforesidue swissprot:ADD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ADD_ECOLI octanol swissprot:ADD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ADD_ECOLI pepcoil swissprot:ADD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ADD_ECOLI pepdigest swissprot:ADD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ADD_ECOLI pepinfo swissprot:ADD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ADD_ECOLI pepnet swissprot:ADD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ADD_ECOLI pepstats swissprot:ADD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ADD_ECOLI pepwheel swissprot:ADD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ADD_ECOLI pepwindow swissprot:ADD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ADD_ECOLI sigcleave swissprot:ADD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ADD_ECOLI ## Database ID URL or Descriptions # BioGrid 4261991 138 # EcoGene EG12780 diaA # FUNCTION DIAA_ECOLI Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein. {ECO 0000269|PubMed 15326179, ECO 0000269|PubMed 17699754}. # GO_function GO:0030246 carbohydrate binding; IEA:UniProtKB-HAMAP. # GO_function GO:0042802 identical protein binding; IPI:IntAct. # GO_process GO:0005975 carbohydrate metabolic process; IEA:UniProtKB-HAMAP. # GO_process GO:0006260 DNA replication; IEA:UniProtKB-HAMAP. # GO_process GO:0032298 positive regulation of DNA-dependent DNA replication initiation; IDA:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # HAMAP MF_01157 SIS_DiaA # INTERACTION DIAA_ECOLI Self; NbExp=5; IntAct=EBI-1125806, EBI-1125806; P03004 dnaA; NbExp=5; IntAct=EBI-1125806, EBI-548951; # IntAct P66817 10 # InterPro IPR001347 SIS # InterPro IPR023070 DiaA # KEGG_Brite ko03036 Chromosome # Organism DIAA_ECOLI Escherichia coli (strain K12) # PATRIC 32121716 VBIEscCol129921_3244 # PDB 2YVA X-ray; 1.85 A; A/B=1-196 # PDB 4U6N X-ray; 1.91 A; A=2-196 # PIR A65105 A65105 # PROSITE PS51464 SIS # Pfam PF13580 SIS_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DIAA_ECOLI DnaA initiator-associating protein DiaA # RefSeq NP_417618 NC_000913.3 # RefSeq WP_001158034 NZ_LN832404.1 # SIMILARITY Belongs to the SIS family. DiaA subfamily. {ECO 0000305}. # SIMILARITY Contains 1 SIS domain. {ECO 0000305}. # SUBUNIT DIAA_ECOLI Homotetramer; dimer of dimers. May be in a rapid association-dissociation equilibrium between homodimers and homotetramers. Formation of homotetramers is required for stimulation of replication. Interacts with DnaA. {ECO 0000269|PubMed 15326179, ECO 0000269|PubMed 17699754}. # eggNOG COG0279 LUCA # eggNOG ENOG4105F55 Bacteria BLAST swissprot:DIAA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DIAA_ECOLI BioCyc ECOL316407:JW3118-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3118-MONOMER BioCyc EcoCyc:YRAO-MONOMER http://biocyc.org/getid?id=EcoCyc:YRAO-MONOMER COG COG0279 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0279 DIP DIP-35981N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35981N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M402762200 http://dx.doi.org/10.1074/jbc.M402762200 DOI 10.1101/gad.1561207 http://dx.doi.org/10.1101/gad.1561207 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2633 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2633 EcoGene EG12780 http://www.ecogene.org/geneInfo.php?eg_id=EG12780 EnsemblBacteria AAC76183 http://www.ensemblgenomes.org/id/AAC76183 EnsemblBacteria AAC76183 http://www.ensemblgenomes.org/id/AAC76183 EnsemblBacteria BAE77195 http://www.ensemblgenomes.org/id/BAE77195 EnsemblBacteria BAE77195 http://www.ensemblgenomes.org/id/BAE77195 EnsemblBacteria BAE77195 http://www.ensemblgenomes.org/id/BAE77195 EnsemblBacteria b3149 http://www.ensemblgenomes.org/id/b3149 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0030246 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030246 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GO_process GO:0006260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260 GO_process GO:0032298 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032298 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 947661 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947661 HAMAP MF_01157 http://hamap.expasy.org/unirule/MF_01157 HOGENOM HOG000237572 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000237572&db=HOGENOM6 InParanoid P66817 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P66817 IntAct P66817 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P66817* InterPro IPR001347 http://www.ebi.ac.uk/interpro/entry/IPR001347 InterPro IPR023070 http://www.ebi.ac.uk/interpro/entry/IPR023070 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene ecj:JW3118 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3118 KEGG_Gene eco:b3149 http://www.genome.jp/dbget-bin/www_bget?eco:b3149 KEGG_Orthology KO:K12961 http://www.genome.jp/dbget-bin/www_bget?KO:K12961 OMA LHEEVYA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LHEEVYA PDB 2YVA http://www.ebi.ac.uk/pdbe-srv/view/entry/2YVA PDB 4U6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4U6N PDBsum 2YVA http://www.ebi.ac.uk/pdbsum/2YVA PDBsum 4U6N http://www.ebi.ac.uk/pdbsum/4U6N PROSITE PS51464 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51464 PSORT swissprot:DIAA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DIAA_ECOLI PSORT-B swissprot:DIAA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DIAA_ECOLI PSORT2 swissprot:DIAA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DIAA_ECOLI Pfam PF13580 http://pfam.xfam.org/family/PF13580 Phobius swissprot:DIAA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DIAA_ECOLI PhylomeDB P66817 http://phylomedb.org/?seqid=P66817 ProteinModelPortal P66817 http://www.proteinmodelportal.org/query/uniprot/P66817 PubMed 15326179 http://www.ncbi.nlm.nih.gov/pubmed/15326179 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17699754 http://www.ncbi.nlm.nih.gov/pubmed/17699754 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417618 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417618 RefSeq WP_001158034 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001158034 SMR P66817 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P66817 STRING 511145.b3149 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3149&targetmode=cogs STRING COG0279 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0279&targetmode=cogs UniProtKB DIAA_ECOLI http://www.uniprot.org/uniprot/DIAA_ECOLI UniProtKB-AC P66817 http://www.uniprot.org/uniprot/P66817 charge swissprot:DIAA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DIAA_ECOLI eggNOG COG0279 http://eggnogapi.embl.de/nog_data/html/tree/COG0279 eggNOG ENOG4105F55 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F55 epestfind swissprot:DIAA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DIAA_ECOLI garnier swissprot:DIAA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DIAA_ECOLI helixturnhelix swissprot:DIAA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DIAA_ECOLI hmoment swissprot:DIAA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DIAA_ECOLI iep swissprot:DIAA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DIAA_ECOLI inforesidue swissprot:DIAA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DIAA_ECOLI octanol swissprot:DIAA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DIAA_ECOLI pepcoil swissprot:DIAA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DIAA_ECOLI pepdigest swissprot:DIAA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DIAA_ECOLI pepinfo swissprot:DIAA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DIAA_ECOLI pepnet swissprot:DIAA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DIAA_ECOLI pepstats swissprot:DIAA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DIAA_ECOLI pepwheel swissprot:DIAA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DIAA_ECOLI pepwindow swissprot:DIAA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DIAA_ECOLI sigcleave swissprot:DIAA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DIAA_ECOLI ## Database ID URL or Descriptions # BRENDA 2.7.10 2026 # BioGrid 4261406 386 # CATALYTIC ACTIVITY ETK_ECOLI ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. # CAUTION Seems to be expressed only in enteropathogenic E.coli strains; in E.coli K12 / MG1655 and K12 / W3110 this operon is silenced by an IS1D insertion in the promoter region. {ECO 0000305}. # EcoGene EG11826 etk # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_component GO:0016021 integral component of membrane; IDA:EcoCyc. # GO_function GO:0004713 protein tyrosine kinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0000271 polysaccharide biosynthetic process; IBA:GO_Central. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IEA:InterPro. # GO_process GO:0038083 peptidyl-tyrosine autophosphorylation; IDA:EcoCyc. # GO_process GO:0045226 extracellular polysaccharide biosynthetic process; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.300 -; 1. # INTERACTION ETK_ECOLI Self; NbExp=4; IntAct=EBI-562015, EBI-562015; # IntAct P38134 2 # InterPro IPR003856 LipoPS_biosynth # InterPro IPR005702 EPS_synthesis # InterPro IPR025669 AAA_dom # InterPro IPR027417 P-loop_NTPase # InterPro IPR032807 GNVR # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01001 Protein kinases # Organism ETK_ECOLI Escherichia coli (strain K12) # PATRIC 32117185 VBIEscCol129921_1016 # PDB 3CIO X-ray; 2.50 A; A/D=452-726 # PIR C64839 C64839 # PTM ETK_ECOLI Autophosphorylated. Dephosphorylated by etp. # Pfam PF02706 Wzz # Pfam PF13614 AAA_31 # Pfam PF13807 GNVR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ETK_ECOLI Tyrosine-protein kinase etk # RefSeq NP_415501 NC_000913.3 # RefSeq WP_000208650 NZ_LN832404.1 # SIMILARITY Belongs to the etk/wzc family. {ECO 0000305}. # SUBCELLULAR LOCATION ETK_ECOLI Cell inner membrane; Multi-pass membrane protein. Note=When the protein is overexpressed. # SUPFAM SSF52540 SSF52540 # TCDB 8.A.3.3 the cytoplasmic membrane-periplasmic auxiliary-1 (mpa1) protein with cytoplasmic (c) domain (mpa1-c or mpa1+c) family # TIGRFAMs TIGR01007 eps_fam # eggNOG COG0489 LUCA # eggNOG COG3206 LUCA # eggNOG ENOG4105D75 Bacteria BLAST swissprot:ETK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ETK_ECOLI BioCyc ECOL316407:JW0964-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0964-MONOMER BioCyc EcoCyc:EG11826-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11826-MONOMER BioCyc MetaCyc:EG11826-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11826-MONOMER COG COG0489 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0489 COG COG3206 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3206 DIP DIP-9526N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9526N DOI 10.1006/jmbi.2000.4217 http://dx.doi.org/10.1006/jmbi.2000.4217 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.10.- http://www.genome.jp/dbget-bin/www_bget?EC:2.7.10.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M58708 http://www.ebi.ac.uk/ena/data/view/M58708 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.10.- http://enzyme.expasy.org/EC/2.7.10.- EchoBASE EB1773 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1773 EcoGene EG11826 http://www.ecogene.org/geneInfo.php?eg_id=EG11826 EnsemblBacteria AAC74066 http://www.ensemblgenomes.org/id/AAC74066 EnsemblBacteria AAC74066 http://www.ensemblgenomes.org/id/AAC74066 EnsemblBacteria BAA35746 http://www.ensemblgenomes.org/id/BAA35746 EnsemblBacteria BAA35746 http://www.ensemblgenomes.org/id/BAA35746 EnsemblBacteria BAA35746 http://www.ensemblgenomes.org/id/BAA35746 EnsemblBacteria b0981 http://www.ensemblgenomes.org/id/b0981 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0004713 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004713 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0000271 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000271 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GO_process GO:0038083 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0038083 GO_process GO:0045226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045226 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947409 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947409 HOGENOM HOG000153997 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000153997&db=HOGENOM6 InParanoid P38134 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P38134 IntAct P38134 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P38134* IntEnz 2.7.10 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.10 InterPro IPR003856 http://www.ebi.ac.uk/interpro/entry/IPR003856 InterPro IPR005702 http://www.ebi.ac.uk/interpro/entry/IPR005702 InterPro IPR025669 http://www.ebi.ac.uk/interpro/entry/IPR025669 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR032807 http://www.ebi.ac.uk/interpro/entry/IPR032807 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01001 http://www.genome.jp/dbget-bin/www_bget?ko01001 KEGG_Gene ecj:JW0964 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0964 KEGG_Gene eco:b0981 http://www.genome.jp/dbget-bin/www_bget?eco:b0981 KEGG_Orthology KO:K16692 http://www.genome.jp/dbget-bin/www_bget?KO:K16692 MINT MINT-6743651 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-6743651 OMA NEIGRQY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NEIGRQY PDB 3CIO http://www.ebi.ac.uk/pdbe-srv/view/entry/3CIO PDBsum 3CIO http://www.ebi.ac.uk/pdbsum/3CIO PSORT swissprot:ETK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ETK_ECOLI PSORT-B swissprot:ETK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ETK_ECOLI PSORT2 swissprot:ETK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ETK_ECOLI Pfam PF02706 http://pfam.xfam.org/family/PF02706 Pfam PF13614 http://pfam.xfam.org/family/PF13614 Pfam PF13807 http://pfam.xfam.org/family/PF13807 Phobius swissprot:ETK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ETK_ECOLI PhylomeDB P38134 http://phylomedb.org/?seqid=P38134 ProteinModelPortal P38134 http://www.proteinmodelportal.org/query/uniprot/P38134 PubMed 11090276 http://www.ncbi.nlm.nih.gov/pubmed/11090276 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2168385 http://www.ncbi.nlm.nih.gov/pubmed/2168385 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415501 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415501 RefSeq WP_000208650 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000208650 SMR P38134 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P38134 STRING 511145.b0981 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0981&targetmode=cogs STRING COG0489 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0489&targetmode=cogs STRING COG3206 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3206&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 8.A.3.3 http://www.tcdb.org/search/result.php?tc=8.A.3.3 TIGRFAMs TIGR01007 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01007 UniProtKB ETK_ECOLI http://www.uniprot.org/uniprot/ETK_ECOLI UniProtKB-AC P38134 http://www.uniprot.org/uniprot/P38134 charge swissprot:ETK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ETK_ECOLI eggNOG COG0489 http://eggnogapi.embl.de/nog_data/html/tree/COG0489 eggNOG COG3206 http://eggnogapi.embl.de/nog_data/html/tree/COG3206 eggNOG ENOG4105D75 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D75 epestfind swissprot:ETK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ETK_ECOLI garnier swissprot:ETK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ETK_ECOLI helixturnhelix swissprot:ETK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ETK_ECOLI hmoment swissprot:ETK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ETK_ECOLI iep swissprot:ETK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ETK_ECOLI inforesidue swissprot:ETK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ETK_ECOLI octanol swissprot:ETK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ETK_ECOLI pepcoil swissprot:ETK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ETK_ECOLI pepdigest swissprot:ETK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ETK_ECOLI pepinfo swissprot:ETK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ETK_ECOLI pepnet swissprot:ETK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ETK_ECOLI pepstats swissprot:ETK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ETK_ECOLI pepwheel swissprot:ETK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ETK_ECOLI pepwindow swissprot:ETK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ETK_ECOLI sigcleave swissprot:ETK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ETK_ECOLI ## Database ID URL or Descriptions # AltName MOTA_ECOLI Chemotaxis protein MotA # BioGrid 4262245 486 # EcoGene EG10601 motA # FUNCTION MOTA_ECOLI MotA and MotB comprise the stator element of the flagellar motor complex. Required for rotation of the flagellar motor. Probable transmembrane proton channel. Overexpression of MotA, with or without MotB, restores motility in a yhjH disruption, (a c-di-GMP phosphodiesterase) suggesting there is an interaction (direct or indirect) between the c-di-GMP-binding flagellar brake protein YcgR and the flagellar stator. {ECO 0000269|PubMed 20346719}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IDA:EcoliWiki. # GO_function GO:0008565 protein transporter activity; IEA:InterPro. # GO_process GO:0006935 chemotaxis; IEA:UniProtKB-KW. # GO_process GO:0015992 proton transport; IEA:UniProtKB-KW. # GO_process GO:0071973 bacterial-type flagellum-dependent cell motility; IMP:EcoliWiki. # GO_process GO:0071978 bacterial-type flagellum-dependent swarming motility; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0008565 protein transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0040011 locomotion # GOslim_process GO:0048870 cell motility # IntAct P09348 2 # InterPro IPR000540 Flag_MotA_CS # InterPro IPR002898 MotA_ExbB_proton_chnl # InterPro IPR022522 Flagellar_motor_stator_MotA # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02000 Transporters # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Pathway ko02020 Two-component system # KEGG_Pathway ko02030 Bacterial chemotaxis # KEGG_Pathway ko02040 Flagellar assembly # Organism MOTA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30433:SF4 PTHR30433:SF4 # PATRIC 32119107 VBIEscCol129921_1971 # PIR A30279 QRECMA # PROSITE PS01307 MOTA # Pfam PF01618 MotA_ExbB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MOTA_ECOLI Motility protein A # RefSeq NP_416404 NC_000913.3 # RefSeq WP_000906340 NZ_LN832404.1 # SIMILARITY Belongs to the MotA family. {ECO 0000305}. # SUBCELLULAR LOCATION MOTA_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT MOTA_ECOLI Each stator complex is composed of 4 MotA and 2 MotB subunits; in E.coli 11 to 12 stator complexes can be involved in flagellar rotation. 2 A subunits and 1 B subunit are thought to form a single ion channel, so that each stator complex contains two channels. Interacts with FliG. Interacts with flagellar brake protein YcgR in the flagellar basal bodies (PubMed 20303158). In another study (PubMed 20346719) YcgR was not seen to interact with MotA, but instead with FliM and FliG, also in the flagellar basal body. {ECO 0000269|PubMed 20303158, ECO 0000269|PubMed 20346719}. # TCDB 1.A.30.1 the h(+)- or na(+)-translocating bacterial flagellar motor/exbbd outer membrane transport energizer (mot/exb) superfamily # TIGRFAMs TIGR03818 MotA1 # eggNOG COG1291 LUCA # eggNOG ENOG4107RD7 Bacteria BLAST swissprot:MOTA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MOTA_ECOLI BioCyc ECOL316407:JW1879-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1879-MONOMER BioCyc EcoCyc:MOTA-FLAGELLAR-MOTOR-STATOR-PROTEIN http://biocyc.org/getid?id=EcoCyc:MOTA-FLAGELLAR-MOTOR-STATOR-PROTEIN COG COG1291 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1291 DIP DIP-10244N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10244N DOI 10.1006/jmbi.1995.0431 http://dx.doi.org/10.1006/jmbi.1995.0431 DOI 10.1016/0022-2836(91)90943-Z http://dx.doi.org/10.1016/0022-2836(91)90943-Z DOI 10.1016/S1937-6448(08)01402-0 http://dx.doi.org/10.1016/S1937-6448(08)01402-0 DOI 10.1016/j.cell.2010.01.018 http://dx.doi.org/10.1016/j.cell.2010.01.018 DOI 10.1016/j.molcel.2010.03.001 http://dx.doi.org/10.1016/j.molcel.2010.03.001 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01652 http://www.ebi.ac.uk/ena/data/view/J01652 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0596 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0596 EcoGene EG10601 http://www.ecogene.org/geneInfo.php?eg_id=EG10601 EnsemblBacteria AAC74960 http://www.ensemblgenomes.org/id/AAC74960 EnsemblBacteria AAC74960 http://www.ensemblgenomes.org/id/AAC74960 EnsemblBacteria BAA15711 http://www.ensemblgenomes.org/id/BAA15711 EnsemblBacteria BAA15711 http://www.ensemblgenomes.org/id/BAA15711 EnsemblBacteria BAA15711 http://www.ensemblgenomes.org/id/BAA15711 EnsemblBacteria b1890 http://www.ensemblgenomes.org/id/b1890 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GO_process GO:0006935 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006935 GO_process GO:0015992 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015992 GO_process GO:0071973 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071973 GO_process GO:0071978 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071978 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0040011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 GeneID 947564 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947564 HOGENOM HOG000254701 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000254701&db=HOGENOM6 InParanoid P09348 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P09348 IntAct P09348 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P09348* InterPro IPR000540 http://www.ebi.ac.uk/interpro/entry/IPR000540 InterPro IPR002898 http://www.ebi.ac.uk/interpro/entry/IPR002898 InterPro IPR022522 http://www.ebi.ac.uk/interpro/entry/IPR022522 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW1879 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1879 KEGG_Gene eco:b1890 http://www.genome.jp/dbget-bin/www_bget?eco:b1890 KEGG_Orthology KO:K02556 http://www.genome.jp/dbget-bin/www_bget?KO:K02556 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 KEGG_Pathway ko02030 http://www.genome.jp/kegg-bin/show_pathway?ko02030 KEGG_Pathway ko02040 http://www.genome.jp/kegg-bin/show_pathway?ko02040 MINT MINT-1250843 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1250843 OMA AFICDYL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AFICDYL PANTHER PTHR30433:SF4 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30433:SF4 PROSITE PS01307 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01307 PSORT swissprot:MOTA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MOTA_ECOLI PSORT-B swissprot:MOTA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MOTA_ECOLI PSORT2 swissprot:MOTA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MOTA_ECOLI Pfam PF01618 http://pfam.xfam.org/family/PF01618 Phobius swissprot:MOTA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MOTA_ECOLI PhylomeDB P09348 http://phylomedb.org/?seqid=P09348 ProteinModelPortal P09348 http://www.proteinmodelportal.org/query/uniprot/P09348 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1719217 http://www.ncbi.nlm.nih.gov/pubmed/1719217 PubMed 19081534 http://www.ncbi.nlm.nih.gov/pubmed/19081534 PubMed 20303158 http://www.ncbi.nlm.nih.gov/pubmed/20303158 PubMed 20346719 http://www.ncbi.nlm.nih.gov/pubmed/20346719 PubMed 3007435 http://www.ncbi.nlm.nih.gov/pubmed/3007435 PubMed 6090403 http://www.ncbi.nlm.nih.gov/pubmed/6090403 PubMed 7643400 http://www.ncbi.nlm.nih.gov/pubmed/7643400 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416404 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416404 RefSeq WP_000906340 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000906340 STRING 511145.b1890 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1890&targetmode=cogs STRING COG1291 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1291&targetmode=cogs TCDB 1.A.30.1 http://www.tcdb.org/search/result.php?tc=1.A.30.1 TIGRFAMs TIGR03818 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03818 UniProtKB MOTA_ECOLI http://www.uniprot.org/uniprot/MOTA_ECOLI UniProtKB-AC P09348 http://www.uniprot.org/uniprot/P09348 charge swissprot:MOTA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MOTA_ECOLI eggNOG COG1291 http://eggnogapi.embl.de/nog_data/html/tree/COG1291 eggNOG ENOG4107RD7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107RD7 epestfind swissprot:MOTA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MOTA_ECOLI garnier swissprot:MOTA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MOTA_ECOLI helixturnhelix swissprot:MOTA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MOTA_ECOLI hmoment swissprot:MOTA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MOTA_ECOLI iep swissprot:MOTA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MOTA_ECOLI inforesidue swissprot:MOTA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MOTA_ECOLI octanol swissprot:MOTA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MOTA_ECOLI pepcoil swissprot:MOTA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MOTA_ECOLI pepdigest swissprot:MOTA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MOTA_ECOLI pepinfo swissprot:MOTA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MOTA_ECOLI pepnet swissprot:MOTA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MOTA_ECOLI pepstats swissprot:MOTA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MOTA_ECOLI pepwheel swissprot:MOTA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MOTA_ECOLI pepwindow swissprot:MOTA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MOTA_ECOLI sigcleave swissprot:MOTA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MOTA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262929 148 # CATALYTIC ACTIVITY RECG_ECOLI ATP + H(2)O = ADP + phosphate. # DISRUPTION PHENOTYPE RECG_ECOLI Very slight sensitivity to ciprofloxacin (CFX), UV and azidothymidine (AZT) in single deletion mutants, but a radA-recG deletion is extremely sensitive to CFX and AZT, less so to UV (PubMed 12446634, PubMed 25484163). The SOS response is induced in this double mutant, indicating spontaneous DNA damage. AZT sensitivity is suppressed by further recA or recF deletions, suggesting AZT-induced DNA gaps are processed into lethal intermediates in a RecA-dependent fashion mediated by RecF (PubMed 25484163). {ECO 0000269|PubMed 12446634, ECO 0000269|PubMed 25484163}. # EcoGene EG10829 recG # FUNCTION RECG_ECOLI Play a critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA). Has a role in constitutive stable DNA replication (cSDR) and R-loop formation. Is genetically synergistic to RadA and RuvABC (PubMed 12446634, PubMed 25484163). {ECO 0000269|PubMed 12446634, ECO 0000269|PubMed 25484163, ECO 0000269|PubMed 7774596, ECO 0000269|PubMed 7957087}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0009379 Holliday junction helicase complex; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004003 ATP-dependent DNA helicase activity; IDA:EcoCyc. # GO_function GO:0004004 ATP-dependent RNA helicase activity; IBA:GO_Central. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0006281 DNA repair; IEA:UniProtKB-KW. # GO_process GO:0006310 DNA recombination; IEA:UniProtKB-KW. # GO_process GO:0010501 RNA secondary structure unwinding; IBA:GO_Central. # GO_process GO:0032508 DNA duplex unwinding; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004386 helicase activity # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0051276 chromosome organization # Gene3D 3.40.50.300 -; 2. # IntAct P24230 28 # InterPro IPR001650 Helicase_C # InterPro IPR004609 ATP-dep_DNA_helicase_RecG # InterPro IPR011545 DEAD/DEAH_box_helicase_dom # InterPro IPR012340 NA-bd_OB-fold # InterPro IPR014001 Helicase_ATP-bd # InterPro IPR027417 P-loop_NTPase # InterPro IPR033454 RecG_wedge # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko03440 Homologous recombination # Organism RECG_ECOLI Escherichia coli (strain K12) # PATRIC 32122791 VBIEscCol129921_3772 # PIR JH0265 JH0265 # PROSITE PS51192 HELICASE_ATP_BIND_1 # PROSITE PS51194 HELICASE_CTER # Pfam PF00270 DEAD # Pfam PF00271 Helicase_C # Pfam PF17191 RecG_wedge # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RECG_ECOLI ATP-dependent DNA helicase RecG # RefSeq NP_418109 NC_000913.3 # RefSeq WP_000678419 NZ_LN832404.1 # SIMILARITY Belongs to the helicase family. RecG subfamily. {ECO 0000305}. # SIMILARITY Contains 1 helicase ATP-binding domain. {ECO:0000255|PROSITE-ProRule PRU00541}. # SIMILARITY Contains 1 helicase C-terminal domain. {ECO:0000255|PROSITE-ProRule PRU00542}. # SMART SM00487 DEXDc # SMART SM00490 HELICc # SUPFAM SSF50249 SSF50249 # SUPFAM SSF52540 SSF52540; 3 # TIGRFAMs TIGR00643 recG # eggNOG COG1200 LUCA # eggNOG ENOG4105CB5 Bacteria BLAST swissprot:RECG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RECG_ECOLI BioCyc ECOL316407:JW3627-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3627-MONOMER BioCyc EcoCyc:EG10829-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10829-MONOMER COG COG1200 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1200 DIP DIP-10653N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10653N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1016/0378-1119(92)90449-Y http://dx.doi.org/10.1016/0378-1119(92)90449-Y DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/mmi.12899 http://dx.doi.org/10.1111/mmi.12899 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.22.6287-6291.2000 http://dx.doi.org/10.1128/JB.182.22.6287-6291.2000 DOI 10.1128/JB.184.24.6836-6844.2002 http://dx.doi.org/10.1128/JB.184.24.6836-6844.2002 EC_number EC:3.6.4.12 http://www.genome.jp/dbget-bin/www_bget?EC:3.6.4.12 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M64367 http://www.ebi.ac.uk/ena/data/view/M64367 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X59550 http://www.ebi.ac.uk/ena/data/view/X59550 ENZYME 3.6.4.12 http://enzyme.expasy.org/EC/3.6.4.12 EchoBASE EB0822 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0822 EcoGene EG10829 http://www.ecogene.org/geneInfo.php?eg_id=EG10829 EnsemblBacteria AAC76676 http://www.ensemblgenomes.org/id/AAC76676 EnsemblBacteria AAC76676 http://www.ensemblgenomes.org/id/AAC76676 EnsemblBacteria BAE77641 http://www.ensemblgenomes.org/id/BAE77641 EnsemblBacteria BAE77641 http://www.ensemblgenomes.org/id/BAE77641 EnsemblBacteria BAE77641 http://www.ensemblgenomes.org/id/BAE77641 EnsemblBacteria b3652 http://www.ensemblgenomes.org/id/b3652 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0009379 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009379 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004003 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004003 GO_function GO:0004004 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004004 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006281 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0010501 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010501 GO_process GO:0032508 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032508 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004386 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0051276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051276 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948162 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948162 HOGENOM HOG000036617 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000036617&db=HOGENOM6 InParanoid P24230 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P24230 IntAct P24230 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P24230* IntEnz 3.6.4.12 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.4.12 InterPro IPR001650 http://www.ebi.ac.uk/interpro/entry/IPR001650 InterPro IPR004609 http://www.ebi.ac.uk/interpro/entry/IPR004609 InterPro IPR011545 http://www.ebi.ac.uk/interpro/entry/IPR011545 InterPro IPR012340 http://www.ebi.ac.uk/interpro/entry/IPR012340 InterPro IPR014001 http://www.ebi.ac.uk/interpro/entry/IPR014001 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR033454 http://www.ebi.ac.uk/interpro/entry/IPR033454 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW3627 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3627 KEGG_Gene eco:b3652 http://www.genome.jp/dbget-bin/www_bget?eco:b3652 KEGG_Orthology KO:K03655 http://www.genome.jp/dbget-bin/www_bget?KO:K03655 KEGG_Pathway ko03440 http://www.genome.jp/kegg-bin/show_pathway?ko03440 MINT MINT-1301344 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1301344 OMA SYYADLD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SYYADLD PROSITE PS51192 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51192 PROSITE PS51194 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51194 PSORT swissprot:RECG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RECG_ECOLI PSORT-B swissprot:RECG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RECG_ECOLI PSORT2 swissprot:RECG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RECG_ECOLI Pfam PF00270 http://pfam.xfam.org/family/PF00270 Pfam PF00271 http://pfam.xfam.org/family/PF00271 Pfam PF17191 http://pfam.xfam.org/family/PF17191 Phobius swissprot:RECG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RECG_ECOLI PhylomeDB P24230 http://phylomedb.org/?seqid=P24230 ProteinModelPortal P24230 http://www.proteinmodelportal.org/query/uniprot/P24230 PubMed 11053371 http://www.ncbi.nlm.nih.gov/pubmed/11053371 PubMed 12446634 http://www.ncbi.nlm.nih.gov/pubmed/12446634 PubMed 1544582 http://www.ncbi.nlm.nih.gov/pubmed/1544582 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1938888 http://www.ncbi.nlm.nih.gov/pubmed/1938888 PubMed 25484163 http://www.ncbi.nlm.nih.gov/pubmed/25484163 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 7774596 http://www.ncbi.nlm.nih.gov/pubmed/7774596 PubMed 7957087 http://www.ncbi.nlm.nih.gov/pubmed/7957087 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418109 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418109 RefSeq WP_000678419 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000678419 SMART SM00487 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00487 SMART SM00490 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00490 SMR P24230 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P24230 STRING 511145.b3652 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3652&targetmode=cogs STRING COG1200 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1200&targetmode=cogs SUPFAM SSF50249 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50249 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR00643 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00643 UniProtKB RECG_ECOLI http://www.uniprot.org/uniprot/RECG_ECOLI UniProtKB-AC P24230 http://www.uniprot.org/uniprot/P24230 charge swissprot:RECG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RECG_ECOLI eggNOG COG1200 http://eggnogapi.embl.de/nog_data/html/tree/COG1200 eggNOG ENOG4105CB5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CB5 epestfind swissprot:RECG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RECG_ECOLI garnier swissprot:RECG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RECG_ECOLI helixturnhelix swissprot:RECG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RECG_ECOLI hmoment swissprot:RECG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RECG_ECOLI iep swissprot:RECG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RECG_ECOLI inforesidue swissprot:RECG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RECG_ECOLI octanol swissprot:RECG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RECG_ECOLI pepcoil swissprot:RECG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RECG_ECOLI pepdigest swissprot:RECG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RECG_ECOLI pepinfo swissprot:RECG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RECG_ECOLI pepnet swissprot:RECG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RECG_ECOLI pepstats swissprot:RECG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RECG_ECOLI pepwheel swissprot:RECG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RECG_ECOLI pepwindow swissprot:RECG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RECG_ECOLI sigcleave swissprot:RECG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RECG_ECOLI ## Database ID URL or Descriptions # BioGrid 4260221 3 # DISRUPTION PHENOTYPE Cannot be disrupted, suggesting it is a functional antitoxin. No visible phenotype when the hipBA operon is deleted. {ECO:0000269|PubMed 8021189}. # ENZYME REGULATION Degraded by Lon protease; degradation is inhibited in a HipA-HipB complex and when bound to the operator consensus sequence dsDNA. {ECO:0000269|PubMed 22720069}. # EcoGene EG10442 hipB # FUNCTION HIPB_ECOLI Antitoxin component of a toxin-antitoxin (TA) module. Neutralizes the toxic effect of cognate toxin HipA. Binds to operator sites with the consensus sequence 5-'TATCCN(8)GGATA-3' to repress the hipBA operon promoter; binding to DNA induces a 70 degree bend. {ECO 0000269|PubMed 8021189}. # GO_function GO:0000985 bacterial-type RNA polymerase core promoter sequence-specific DNA binding; IDA:EcoCyc. # GO_function GO:0043565 sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.260.40 -; 1. # IntAct P23873 2 # InterPro IPR001387 Cro/C1-type_HTH # InterPro IPR010982 Lambda_DNA-bd_dom # KEGG_Brite ko03000 Transcription factors # Organism HIPB_ECOLI Escherichia coli (strain K12) # PATRIC 32118310 VBIEscCol129921_1575 # PDB 2WIU X-ray; 2.35 A; B/D=1-88 # PDB 3DNV X-ray; 2.68 A; B=1-88 # PDB 3HZI X-ray; 2.98 A; B=1-88 # PDB 4YG1 X-ray; 3.25 A; A/B/C/D=1-72 # PDB 4YG4 X-ray; 3.50 A; A/B/C/D=4-74 # PDB 4YG7 X-ray; 3.77 A; B/C/E/G=4-74 # PDB 4Z58 X-ray; 2.50 A; A=4-74 # PDB 4Z59 X-ray; 2.30 A; A=4-74 # PDB 4Z5C X-ray; 2.50 A; A/B=4-74 # PDB 4Z5D X-ray; 2.15 A; A/B=4-74 # PDB 4Z5H X-ray; 2.10 A; A=3-74 # PIR A38112 A38112 # PROSITE PS50943 HTH_CROC1 # PTM HIPB_ECOLI Degraded by Lon protease in vivo; half-life is 17 minutes in wild-type cells and over 200 minutes in a lon deletion strain. In vitro degradation by Lon is Mg(2+)-ATP-dependent. # Pfam PF01381 HTH_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HIPB_ECOLI Antitoxin HipB # RefSeq NP_416025 NC_000913.3 # RefSeq WP_001301023 NZ_LN832404.1 # SIMILARITY Contains 1 HTH cro/C1-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00257}. # SMART SM00530 HTH_XRE # SUBUNIT HIPB_ECOLI Homodimer. Forms a HipA(2)HipB(2) heterotetramer which can interact with DNA. This complex also blocks the toxic activity of HipA. {ECO 0000269|PubMed 19150849, ECO 0000269|PubMed 19622872, ECO 0000269|PubMed 24089363, ECO 0000269|PubMed 8021189}. # SUPFAM SSF47413 SSF47413 # eggNOG COG1396 LUCA # eggNOG ENOG41061P8 Bacteria BLAST swissprot:HIPB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HIPB_ECOLI BioCyc ECOL316407:JW1501-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1501-MONOMER BioCyc EcoCyc:EG10442-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10442-MONOMER BioCyc MetaCyc:EG10442-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10442-MONOMER COG COG1396 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1396 DIP DIP-9899N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9899N DOI 10.1002/jmr.2300 http://dx.doi.org/10.1002/jmr.2300 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1107/S0907444909018800 http://dx.doi.org/10.1107/S0907444909018800 DOI 10.1126/science.1163806 http://dx.doi.org/10.1126/science.1163806 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pone.0039185 http://dx.doi.org/10.1371/journal.pone.0039185 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M61242 http://www.ebi.ac.uk/ena/data/view/M61242 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0437 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0437 EcoGene EG10442 http://www.ecogene.org/geneInfo.php?eg_id=EG10442 EnsemblBacteria AAC74581 http://www.ensemblgenomes.org/id/AAC74581 EnsemblBacteria AAC74581 http://www.ensemblgenomes.org/id/AAC74581 EnsemblBacteria BAA15180 http://www.ensemblgenomes.org/id/BAA15180 EnsemblBacteria BAA15180 http://www.ensemblgenomes.org/id/BAA15180 EnsemblBacteria BAA15180 http://www.ensemblgenomes.org/id/BAA15180 EnsemblBacteria b1508 http://www.ensemblgenomes.org/id/b1508 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000985 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000985 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.260.40 http://www.cathdb.info/version/latest/superfamily/1.10.260.40 GeneID 946065 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946065 HOGENOM HOG000225389 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000225389&db=HOGENOM6 InParanoid P23873 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23873 IntAct P23873 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P23873* InterPro IPR001387 http://www.ebi.ac.uk/interpro/entry/IPR001387 InterPro IPR010982 http://www.ebi.ac.uk/interpro/entry/IPR010982 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW1501 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1501 KEGG_Gene eco:b1508 http://www.genome.jp/dbget-bin/www_bget?eco:b1508 KEGG_Orthology KO:K15773 http://www.genome.jp/dbget-bin/www_bget?KO:K15773 OMA HALEVHC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HALEVHC PDB 2WIU http://www.ebi.ac.uk/pdbe-srv/view/entry/2WIU PDB 3DNV http://www.ebi.ac.uk/pdbe-srv/view/entry/3DNV PDB 3HZI http://www.ebi.ac.uk/pdbe-srv/view/entry/3HZI PDB 4YG1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4YG1 PDB 4YG4 http://www.ebi.ac.uk/pdbe-srv/view/entry/4YG4 PDB 4YG7 http://www.ebi.ac.uk/pdbe-srv/view/entry/4YG7 PDB 4Z58 http://www.ebi.ac.uk/pdbe-srv/view/entry/4Z58 PDB 4Z59 http://www.ebi.ac.uk/pdbe-srv/view/entry/4Z59 PDB 4Z5C http://www.ebi.ac.uk/pdbe-srv/view/entry/4Z5C PDB 4Z5D http://www.ebi.ac.uk/pdbe-srv/view/entry/4Z5D PDB 4Z5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4Z5H PDBsum 2WIU http://www.ebi.ac.uk/pdbsum/2WIU PDBsum 3DNV http://www.ebi.ac.uk/pdbsum/3DNV PDBsum 3HZI http://www.ebi.ac.uk/pdbsum/3HZI PDBsum 4YG1 http://www.ebi.ac.uk/pdbsum/4YG1 PDBsum 4YG4 http://www.ebi.ac.uk/pdbsum/4YG4 PDBsum 4YG7 http://www.ebi.ac.uk/pdbsum/4YG7 PDBsum 4Z58 http://www.ebi.ac.uk/pdbsum/4Z58 PDBsum 4Z59 http://www.ebi.ac.uk/pdbsum/4Z59 PDBsum 4Z5C http://www.ebi.ac.uk/pdbsum/4Z5C PDBsum 4Z5D http://www.ebi.ac.uk/pdbsum/4Z5D PDBsum 4Z5H http://www.ebi.ac.uk/pdbsum/4Z5H PROSITE PS50943 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50943 PSORT swissprot:HIPB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HIPB_ECOLI PSORT-B swissprot:HIPB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HIPB_ECOLI PSORT2 swissprot:HIPB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HIPB_ECOLI Pfam PF01381 http://pfam.xfam.org/family/PF01381 Phobius swissprot:HIPB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HIPB_ECOLI ProteinModelPortal P23873 http://www.proteinmodelportal.org/query/uniprot/P23873 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1715862 http://www.ncbi.nlm.nih.gov/pubmed/1715862 PubMed 19150849 http://www.ncbi.nlm.nih.gov/pubmed/19150849 PubMed 19622872 http://www.ncbi.nlm.nih.gov/pubmed/19622872 PubMed 22720069 http://www.ncbi.nlm.nih.gov/pubmed/22720069 PubMed 24089363 http://www.ncbi.nlm.nih.gov/pubmed/24089363 PubMed 8021189 http://www.ncbi.nlm.nih.gov/pubmed/8021189 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416025 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416025 RefSeq WP_001301023 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001301023 SMART SM00530 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00530 SMR P23873 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P23873 STRING 511145.b1508 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1508&targetmode=cogs STRING COG1396 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1396&targetmode=cogs SUPFAM SSF47413 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47413 UniProtKB HIPB_ECOLI http://www.uniprot.org/uniprot/HIPB_ECOLI UniProtKB-AC P23873 http://www.uniprot.org/uniprot/P23873 charge swissprot:HIPB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HIPB_ECOLI eggNOG COG1396 http://eggnogapi.embl.de/nog_data/html/tree/COG1396 eggNOG ENOG41061P8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41061P8 epestfind swissprot:HIPB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HIPB_ECOLI garnier swissprot:HIPB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HIPB_ECOLI helixturnhelix swissprot:HIPB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HIPB_ECOLI hmoment swissprot:HIPB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HIPB_ECOLI iep swissprot:HIPB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HIPB_ECOLI inforesidue swissprot:HIPB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HIPB_ECOLI octanol swissprot:HIPB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HIPB_ECOLI pepcoil swissprot:HIPB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HIPB_ECOLI pepdigest swissprot:HIPB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HIPB_ECOLI pepinfo swissprot:HIPB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HIPB_ECOLI pepnet swissprot:HIPB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HIPB_ECOLI pepstats swissprot:HIPB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HIPB_ECOLI pepwheel swissprot:HIPB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HIPB_ECOLI pepwindow swissprot:HIPB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HIPB_ECOLI sigcleave swissprot:HIPB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HIPB_ECOLI ## Database ID URL or Descriptions # AltName SYS_ECOLI Seryl-tRNA synthetase # AltName SYS_ECOLI Seryl-tRNA(Ser/Sec) synthetase # BIOPHYSICOCHEMICAL PROPERTIES SYS_ECOLI Kinetic parameters KM=64 uM for serine {ECO 0000269|PubMed 7537870, ECO 0000269|PubMed 8065908}; KM=0.068 uM for ATP {ECO 0000269|PubMed 7537870, ECO 0000269|PubMed 8065908}; # BioGrid 4261485 9 # CATALYTIC ACTIVITY SYS_ECOLI ATP + L-serine + tRNA(Sec) = AMP + diphosphate + L-seryl-tRNA(Sec). # CATALYTIC ACTIVITY SYS_ECOLI ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser). # CDD cd00770 SerRS_core # DOMAIN SYS_ECOLI Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding. {ECO 0000269|PubMed 8065908, ECO 0000269|PubMed 8508916}. # EcoGene EG10947 serS # FUNCTION SYS_ECOLI Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). {ECO 0000269|PubMed 2963963, ECO 0000269|PubMed 7537870, ECO 0000269|PubMed 8065908}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0004828 serine-tRNA ligase activity; IDA:UniProtKB. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006434 seryl-tRNA aminoacylation; IDA:UniProtKB. # GO_process GO:0016260 selenocysteine biosynthetic process; IDA:EcoCyc. # GO_process GO:0097056 selenocysteinyl-tRNA(Sec) biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 1.10.287.40 -; 1. # HAMAP MF_00176 Ser_tRNA_synth_type1 # INTERACTION SYS_ECOLI Self; NbExp=3; IntAct=EBI-548422, EBI-548422; # IntAct P0A8L1 16 # InterPro IPR002314 aa-tRNA-synt_IIb # InterPro IPR002317 Ser-tRNA-ligase_type_1 # InterPro IPR006195 aa-tRNA-synth_II # InterPro IPR010978 tRNA-bd_arm # InterPro IPR015866 Ser-tRNA-synth_1_N # InterPro IPR033729 SerRS_core # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01007 Amino acid related enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # KEGG_Pathway ko00970 Aminoacyl-tRNA biosynthesis # Organism SYS_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11778 PTHR11778 # PATHWAY Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec) step 1/1. # PATRIC 32116997 VBIEscCol129921_0923 # PIR A26400 YSEC # PIRSF PIRSF001529 Ser-tRNA-synth_IIa # PRINTS PR00981 TRNASYNTHSER # PROSITE PS50862 AA_TRNA_LIGASE_II # Pfam PF00587 tRNA-synt_2b # Pfam PF02403 Seryl_tRNA_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SYS_ECOLI Serine--tRNA ligase # RefSeq NP_415413 NC_000913.3 # RefSeq WP_000886683 NZ_LN832404.1 # SIMILARITY Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION SYS_ECOLI Cytoplasm {ECO 0000250}. # SUBUNIT SYS_ECOLI Homodimer. The tRNA molecule binds across the dimer. {ECO 0000269|PubMed 7537870, ECO 0000269|PubMed 8508916}. # SUPFAM SSF46589 SSF46589 # TIGRFAMs TIGR00414 serS # UniPathway UPA00906 UER00895 # eggNOG COG0172 LUCA # eggNOG ENOG4105CGR Bacteria BLAST swissprot:SYS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SYS_ECOLI BioCyc ECOL316407:JW0876-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0876-MONOMER BioCyc EcoCyc:SERS-MONOMER http://biocyc.org/getid?id=EcoCyc:SERS-MONOMER BioCyc MetaCyc:SERS-MONOMER http://biocyc.org/getid?id=MetaCyc:SERS-MONOMER COG COG0172 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0172 DIP DIP-35989N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35989N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0014-5793(93)81386-E http://dx.doi.org/10.1016/0014-5793(93)81386-E DOI 10.1016/0167-4781(91)90168-L http://dx.doi.org/10.1016/0167-4781(91)90168-L DOI 10.1038/331723a0 http://dx.doi.org/10.1038/331723a0 DOI 10.1038/347249a0 http://dx.doi.org/10.1038/347249a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/15.3.1005 http://dx.doi.org/10.1093/nar/15.3.1005 DOI 10.1093/nar/22.15.2963 http://dx.doi.org/10.1093/nar/22.15.2963 DOI 10.1093/nar/23.7.1113 http://dx.doi.org/10.1093/nar/23.7.1113 DOI 10.1111/j.1365-2958.1988.tb00090.x http://dx.doi.org/10.1111/j.1365-2958.1988.tb00090.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.1.1.11 http://www.genome.jp/dbget-bin/www_bget?EC:6.1.1.11 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J03412 http://www.ebi.ac.uk/ena/data/view/J03412 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X05017 http://www.ebi.ac.uk/ena/data/view/X05017 ENZYME 6.1.1.11 http://enzyme.expasy.org/EC/6.1.1.11 EchoBASE EB0940 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0940 EcoGene EG10947 http://www.ecogene.org/geneInfo.php?eg_id=EG10947 EnsemblBacteria AAC73979 http://www.ensemblgenomes.org/id/AAC73979 EnsemblBacteria AAC73979 http://www.ensemblgenomes.org/id/AAC73979 EnsemblBacteria BAA35625 http://www.ensemblgenomes.org/id/BAA35625 EnsemblBacteria BAA35625 http://www.ensemblgenomes.org/id/BAA35625 EnsemblBacteria BAA35625 http://www.ensemblgenomes.org/id/BAA35625 EnsemblBacteria b0893 http://www.ensemblgenomes.org/id/b0893 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0004828 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004828 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006434 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006434 GO_process GO:0016260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016260 GO_process GO:0097056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097056 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 1.10.287.40 http://www.cathdb.info/version/latest/superfamily/1.10.287.40 GeneID 945506 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945506 HAMAP MF_00176 http://hamap.expasy.org/unirule/MF_00176 HOGENOM HOG000035938 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000035938&db=HOGENOM6 InParanoid P0A8L1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8L1 IntAct P0A8L1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8L1* IntEnz 6.1.1.11 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.1.1.11 InterPro IPR002314 http://www.ebi.ac.uk/interpro/entry/IPR002314 InterPro IPR002317 http://www.ebi.ac.uk/interpro/entry/IPR002317 InterPro IPR006195 http://www.ebi.ac.uk/interpro/entry/IPR006195 InterPro IPR010978 http://www.ebi.ac.uk/interpro/entry/IPR010978 InterPro IPR015866 http://www.ebi.ac.uk/interpro/entry/IPR015866 InterPro IPR033729 http://www.ebi.ac.uk/interpro/entry/IPR033729 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW0876 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0876 KEGG_Gene eco:b0893 http://www.genome.jp/dbget-bin/www_bget?eco:b0893 KEGG_Orthology KO:K01875 http://www.genome.jp/dbget-bin/www_bget?KO:K01875 KEGG_Pathway ko00970 http://www.genome.jp/kegg-bin/show_pathway?ko00970 KEGG_Reaction rn:R03662 http://www.genome.jp/dbget-bin/www_bget?rn:R03662 KEGG_Reaction rn:R08218 http://www.genome.jp/dbget-bin/www_bget?rn:R08218 MINT MINT-1230011 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1230011 OMA YRPERHE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YRPERHE PANTHER PTHR11778 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11778 PRINTS PR00981 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00981 PROSITE PS50862 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50862 PSORT swissprot:SYS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SYS_ECOLI PSORT-B swissprot:SYS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SYS_ECOLI PSORT2 swissprot:SYS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SYS_ECOLI Pfam PF00587 http://pfam.xfam.org/family/PF00587 Pfam PF02403 http://pfam.xfam.org/family/PF02403 Phobius swissprot:SYS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SYS_ECOLI PhylomeDB P0A8L1 http://phylomedb.org/?seqid=P0A8L1 ProteinModelPortal P0A8L1 http://www.proteinmodelportal.org/query/uniprot/P0A8L1 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1859832 http://www.ncbi.nlm.nih.gov/pubmed/1859832 PubMed 2205803 http://www.ncbi.nlm.nih.gov/pubmed/2205803 PubMed 2963963 http://www.ncbi.nlm.nih.gov/pubmed/2963963 PubMed 3029694 http://www.ncbi.nlm.nih.gov/pubmed/3029694 PubMed 3062312 http://www.ncbi.nlm.nih.gov/pubmed/3062312 PubMed 7537870 http://www.ncbi.nlm.nih.gov/pubmed/7537870 PubMed 8065908 http://www.ncbi.nlm.nih.gov/pubmed/8065908 PubMed 8508916 http://www.ncbi.nlm.nih.gov/pubmed/8508916 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_415413 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415413 RefSeq WP_000886683 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000886683 SMR P0A8L1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8L1 STRING 511145.b0893 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0893&targetmode=cogs STRING COG0172 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0172&targetmode=cogs SUPFAM SSF46589 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46589 SWISS-2DPAGE P0A8L1 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A8L1 TIGRFAMs TIGR00414 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00414 UniProtKB SYS_ECOLI http://www.uniprot.org/uniprot/SYS_ECOLI UniProtKB-AC P0A8L1 http://www.uniprot.org/uniprot/P0A8L1 charge swissprot:SYS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SYS_ECOLI eggNOG COG0172 http://eggnogapi.embl.de/nog_data/html/tree/COG0172 eggNOG ENOG4105CGR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CGR epestfind swissprot:SYS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SYS_ECOLI garnier swissprot:SYS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SYS_ECOLI helixturnhelix swissprot:SYS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SYS_ECOLI hmoment swissprot:SYS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SYS_ECOLI iep swissprot:SYS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SYS_ECOLI inforesidue swissprot:SYS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SYS_ECOLI octanol swissprot:SYS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SYS_ECOLI pepcoil swissprot:SYS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SYS_ECOLI pepdigest swissprot:SYS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SYS_ECOLI pepinfo swissprot:SYS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SYS_ECOLI pepnet swissprot:SYS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SYS_ECOLI pepstats swissprot:SYS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SYS_ECOLI pepwheel swissprot:SYS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SYS_ECOLI pepwindow swissprot:SYS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SYS_ECOLI sigcleave swissprot:SYS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SYS_ECOLI ## Database ID URL or Descriptions # BioGrid 4259279 264 # DISRUPTION PHENOTYPE Leads to irreversible cell damage, growth arrest and an extreme sensitivity to SDS. {ECO:0000269|PubMed 16765569}. # EcoGene EG12806 lptC # FUNCTION LPTC_ECOLI Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. {ECO 0000255|HAMAP-Rule MF_01915, ECO 0000269|PubMed 16765569, ECO 0000269|PubMed 18424520, ECO 0000269|PubMed 20720015, ECO 0000269|PubMed 21169485, ECO 0000269|PubMed 21195693}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IDA:EcoCyc. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0015221 lipopolysaccharide transmembrane transporter activity; IEA:InterPro. # GO_function GO:0017089 glycolipid transporter activity; IMP:EcoCyc. # GO_process GO:0015920 lipopolysaccharide transport; IMP:EcoCyc. # GO_process GO:0043165 Gram-negative-bacterium-type cell outer membrane assembly; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0061024 membrane organization # HAMAP MF_01915 LPS_assembly_LptC # INTERACTION LPTC_ECOLI Self; NbExp=4; IntAct=EBI-1131969, EBI-1131969; P0ADV1 lptA; NbExp=3; IntAct=EBI-1131969, EBI-1132001; # IntAct P0ADV9 3 # InterPro IPR010664 LipoPS_assembly_LptC-rel # InterPro IPR026265 LptC # KEGG_Brite ko02000 Transporters # MISCELLANEOUS Interacts with the LptBFG ABC transporter complex, but does not affect its ATPase activity. {ECO:0000305|PubMed 19500581}. # Organism LPTC_ECOLI Escherichia coli (strain K12) # PATRIC 32121818 VBIEscCol129921_3293 # PDB 3MY2 X-ray; 2.20 A; A=23-191 # PDB 4B54 X-ray; 2.80 A; A/B=24-191 # PIR A65111 A65111 # PIRSF PIRSF028513 LptC # Pfam PF06835 LptC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Lipopolysaccharide export system protein LptC {ECO:0000255|HAMAP-Rule MF_01915} # RefSeq NP_417666 NC_000913.3 # RefSeq WP_000030537 NZ_LN832404.1 # SIMILARITY Belongs to the LptC family. {ECO:0000255|HAMAP- Rule MF_01915}. # SUBCELLULAR LOCATION LPTC_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01915, ECO 0000269|PubMed 18424520, ECO 0000269|PubMed 20720015}; Single-pass membrane protein {ECO 0000255|HAMAP-Rule MF_01915, ECO 0000269|PubMed 18424520, ECO 0000269|PubMed 20720015}. # SUBUNIT LPTC_ECOLI Component of the lipopolysaccharide transport and assembly complex. Interacts with LptA and the LptBFG transporter complex. When overexpressed, can form homodimers in vivo. {ECO 0000255|HAMAP-Rule MF_01915, ECO 0000269|PubMed 19500581, ECO 0000269|PubMed 20446753, ECO 0000269|PubMed 21169485, ECO 0000269|PubMed 21195693, ECO 0000269|PubMed 22668317}. # TIGRFAMs TIGR04409 LptC_YrbK # eggNOG COG3117 LUCA # eggNOG ENOG4108P1K Bacteria BLAST swissprot:LPTC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LPTC_ECOLI BioCyc ECOL316407:JW3166-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3166-MONOMER BioCyc EcoCyc:G7664-MONOMER http://biocyc.org/getid?id=EcoCyc:G7664-MONOMER BioCyc MetaCyc:G7664-MONOMER http://biocyc.org/getid?id=MetaCyc:G7664-MONOMER COG COG3117 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3117 DIP DIP-12912N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12912N DOI 10.1016/j.bbrc.2010.12.121 http://dx.doi.org/10.1016/j.bbrc.2010.12.121 DOI 10.1016/j.febslet.2009.05.051 http://dx.doi.org/10.1016/j.febslet.2009.05.051 DOI 10.1016/j.resmic.2005.11.014 http://dx.doi.org/10.1016/j.resmic.2005.11.014 DOI 10.1021/bi100493e http://dx.doi.org/10.1021/bi100493e DOI 10.1021/bi300592c http://dx.doi.org/10.1021/bi300592c DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.270.9.4822 http://dx.doi.org/10.1074/jbc.270.9.4822 DOI 10.1074/jbc.M110.144709 http://dx.doi.org/10.1074/jbc.M110.144709 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00270-08 http://dx.doi.org/10.1128/JB.00270-08 DOI 10.1128/JB.01037-10 http://dx.doi.org/10.1128/JB.01037-10 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U12684 http://www.ebi.ac.uk/ena/data/view/U12684 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2657 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2657 EcoGene EG12806 http://www.ecogene.org/geneInfo.php?eg_id=EG12806 EnsemblBacteria AAC76231 http://www.ensemblgenomes.org/id/AAC76231 EnsemblBacteria AAC76231 http://www.ensemblgenomes.org/id/AAC76231 EnsemblBacteria BAE77243 http://www.ensemblgenomes.org/id/BAE77243 EnsemblBacteria BAE77243 http://www.ensemblgenomes.org/id/BAE77243 EnsemblBacteria BAE77243 http://www.ensemblgenomes.org/id/BAE77243 EnsemblBacteria b3199 http://www.ensemblgenomes.org/id/b3199 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0015221 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015221 GO_function GO:0017089 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017089 GO_process GO:0015920 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015920 GO_process GO:0043165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043165 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0061024 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024 GeneID 947722 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947722 HAMAP MF_01915 http://hamap.expasy.org/unirule/MF_01915 HOGENOM HOG000125239 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125239&db=HOGENOM6 IntAct P0ADV9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADV9* InterPro IPR010664 http://www.ebi.ac.uk/interpro/entry/IPR010664 InterPro IPR026265 http://www.ebi.ac.uk/interpro/entry/IPR026265 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3166 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3166 KEGG_Gene eco:b3199 http://www.genome.jp/dbget-bin/www_bget?eco:b3199 KEGG_Orthology KO:K11719 http://www.genome.jp/dbget-bin/www_bget?KO:K11719 MINT MINT-7137017 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-7137017 OMA WFTQPVM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WFTQPVM PDB 3MY2 http://www.ebi.ac.uk/pdbe-srv/view/entry/3MY2 PDB 4B54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4B54 PDBsum 3MY2 http://www.ebi.ac.uk/pdbsum/3MY2 PDBsum 4B54 http://www.ebi.ac.uk/pdbsum/4B54 PSORT swissprot:LPTC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LPTC_ECOLI PSORT-B swissprot:LPTC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LPTC_ECOLI PSORT2 swissprot:LPTC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LPTC_ECOLI Pfam PF06835 http://pfam.xfam.org/family/PF06835 Phobius swissprot:LPTC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LPTC_ECOLI ProteinModelPortal P0ADV9 http://www.proteinmodelportal.org/query/uniprot/P0ADV9 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16765569 http://www.ncbi.nlm.nih.gov/pubmed/16765569 PubMed 18424520 http://www.ncbi.nlm.nih.gov/pubmed/18424520 PubMed 19500581 http://www.ncbi.nlm.nih.gov/pubmed/19500581 PubMed 20446753 http://www.ncbi.nlm.nih.gov/pubmed/20446753 PubMed 20720015 http://www.ncbi.nlm.nih.gov/pubmed/20720015 PubMed 21169485 http://www.ncbi.nlm.nih.gov/pubmed/21169485 PubMed 21195693 http://www.ncbi.nlm.nih.gov/pubmed/21195693 PubMed 22668317 http://www.ncbi.nlm.nih.gov/pubmed/22668317 PubMed 7876255 http://www.ncbi.nlm.nih.gov/pubmed/7876255 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417666 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417666 RefSeq WP_000030537 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000030537 SMR P0ADV9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADV9 STRING 511145.b3199 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3199&targetmode=cogs STRING COG3117 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3117&targetmode=cogs TIGRFAMs TIGR04409 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR04409 UniProtKB LPTC_ECOLI http://www.uniprot.org/uniprot/LPTC_ECOLI UniProtKB-AC P0ADV9 http://www.uniprot.org/uniprot/P0ADV9 charge swissprot:LPTC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LPTC_ECOLI eggNOG COG3117 http://eggnogapi.embl.de/nog_data/html/tree/COG3117 eggNOG ENOG4108P1K http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108P1K epestfind swissprot:LPTC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LPTC_ECOLI garnier swissprot:LPTC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LPTC_ECOLI helixturnhelix swissprot:LPTC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LPTC_ECOLI hmoment swissprot:LPTC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LPTC_ECOLI iep swissprot:LPTC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LPTC_ECOLI inforesidue swissprot:LPTC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LPTC_ECOLI octanol swissprot:LPTC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LPTC_ECOLI pepcoil swissprot:LPTC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LPTC_ECOLI pepdigest swissprot:LPTC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LPTC_ECOLI pepinfo swissprot:LPTC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LPTC_ECOLI pepnet swissprot:LPTC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LPTC_ECOLI pepstats swissprot:LPTC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LPTC_ECOLI pepwheel swissprot:LPTC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LPTC_ECOLI pepwindow swissprot:LPTC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LPTC_ECOLI sigcleave swissprot:LPTC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LPTC_ECOLI ## Database ID URL or Descriptions # EcoGene EG40005 insE4 # FUNCTION INSE4_ECOLI Involved in the transposition of the insertion sequence IS3. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 1.10.10.60 -; 1. # InterPro IPR002514 Transposase_8 # InterPro IPR009057 Homeodomain-like # Organism INSE4_ECOLI Escherichia coli (strain K12) # PIR A64845 A64845 # Pfam PF01527 HTH_Tnp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSE4_ECOLI Transposase InsE for insertion sequence IS3D # RefSeq NP_061380 NC_002483.1 # RefSeq NP_061395 NC_002483.1 # RefSeq NP_414832 NC_000913.3 # RefSeq NP_414907 NC_000913.3 # RefSeq NP_415072 NC_000913.3 # RefSeq NP_415546 NC_000913.3 # RefSeq NP_416592 NC_000913.3 # RefSeq WP_000169527 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAE76369.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the transposase 8 family. {ECO 0000305}. # SUPFAM SSF46689 SSF46689 # eggNOG COG2963 LUCA # eggNOG ENOG41090WB Bacteria BLAST swissprot:INSE4_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSE4_ECOLI BioCyc EcoCyc:MONOMER0-4244 http://biocyc.org/getid?id=EcoCyc:MONOMER0-4244 COG COG2963 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2963 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4721 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4721 EcoGene EG40005 http://www.ecogene.org/geneInfo.php?eg_id=EG40005 EnsemblBacteria AAC74112 http://www.ensemblgenomes.org/id/AAC74112 EnsemblBacteria AAC74112 http://www.ensemblgenomes.org/id/AAC74112 EnsemblBacteria BAE76369 http://www.ensemblgenomes.org/id/BAE76369 EnsemblBacteria BAE76369 http://www.ensemblgenomes.org/id/BAE76369 EnsemblBacteria BAE76369 http://www.ensemblgenomes.org/id/BAE76369 EnsemblBacteria b1027 http://www.ensemblgenomes.org/id/b1027 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 GeneID 1263530 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263530 GeneID 1263552 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263552 GeneID 944952 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944952 GeneID 945584 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945584 GeneID 945759 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945759 GeneID 946616 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946616 GeneID 946900 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946900 HOGENOM HOG000266649 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000266649&db=HOGENOM6 InterPro IPR002514 http://www.ebi.ac.uk/interpro/entry/IPR002514 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 KEGG_Gene ecj:JW5144 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5144 KEGG_Gene eco:b0298 http://www.genome.jp/dbget-bin/www_bget?eco:b0298 KEGG_Gene eco:b0373 http://www.genome.jp/dbget-bin/www_bget?eco:b0373 KEGG_Gene eco:b0540 http://www.genome.jp/dbget-bin/www_bget?eco:b0540 KEGG_Gene eco:b1027 http://www.genome.jp/dbget-bin/www_bget?eco:b1027 KEGG_Gene eco:b2088 http://www.genome.jp/dbget-bin/www_bget?eco:b2088 KEGG_Orthology KO:K07483 http://www.genome.jp/dbget-bin/www_bget?KO:K07483 PSORT swissprot:INSE4_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSE4_ECOLI PSORT-B swissprot:INSE4_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSE4_ECOLI PSORT2 swissprot:INSE4_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSE4_ECOLI Pfam PF01527 http://pfam.xfam.org/family/PF01527 Phobius swissprot:INSE4_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSE4_ECOLI ProteinModelPortal P0CF69 http://www.proteinmodelportal.org/query/uniprot/P0CF69 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_061380 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061380 RefSeq NP_061395 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061395 RefSeq NP_414832 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414832 RefSeq NP_414907 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414907 RefSeq NP_415072 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415072 RefSeq NP_415546 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415546 RefSeq NP_416592 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416592 RefSeq WP_000169527 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000169527 STRING 511145.b2088 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2088&targetmode=cogs STRING COG2963 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2963&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 UniProtKB INSE4_ECOLI http://www.uniprot.org/uniprot/INSE4_ECOLI UniProtKB-AC P0CF69 http://www.uniprot.org/uniprot/P0CF69 charge swissprot:INSE4_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSE4_ECOLI eggNOG COG2963 http://eggnogapi.embl.de/nog_data/html/tree/COG2963 eggNOG ENOG41090WB http://eggnogapi.embl.de/nog_data/html/tree/ENOG41090WB epestfind swissprot:INSE4_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSE4_ECOLI garnier swissprot:INSE4_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSE4_ECOLI helixturnhelix swissprot:INSE4_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSE4_ECOLI hmoment swissprot:INSE4_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSE4_ECOLI iep swissprot:INSE4_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSE4_ECOLI inforesidue swissprot:INSE4_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSE4_ECOLI octanol swissprot:INSE4_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSE4_ECOLI pepcoil swissprot:INSE4_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSE4_ECOLI pepdigest swissprot:INSE4_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSE4_ECOLI pepinfo swissprot:INSE4_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSE4_ECOLI pepnet swissprot:INSE4_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSE4_ECOLI pepstats swissprot:INSE4_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSE4_ECOLI pepwheel swissprot:INSE4_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSE4_ECOLI pepwindow swissprot:INSE4_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSE4_ECOLI sigcleave swissprot:INSE4_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSE4_ECOLI ## Database ID URL or Descriptions # AltName ISCU_ECOLI Sulfur acceptor protein IscU # BioGrid 4259432 56 # CDD cd06664 IscU_like # ENZYME REGULATION Carboxymethylation by iodoacetic acid blocks sulfur transfer to this protein. {ECO:0000269|PubMed 11577100}. # EcoGene EG13395 iscU # FUNCTION ISCU_ECOLI A scaffold on which IscS assembles Fe-S clusters. Exists as 2 interconverting forms, a structured (S) and disordered (D) form. The D-state is the preferred substrate for IscS. Converts to the S-state when an Fe-S cluster is assembled, which helps it dissociate from IscS to transfer the Fe-S to an acceptor. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. {ECO 0000269|PubMed 11577100, ECO 0000269|PubMed 22203963}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008198 ferrous iron binding; IBA:GO_Central. # GO_function GO:0036455 iron-sulfur transferase activity; IBA:GO_Central. # GO_function GO:0051537 2 iron, 2 sulfur cluster binding; IDA:EcoCyc. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IDA:EcoCyc. # GO_process GO:0006879 cellular iron ion homeostasis; IBA:GO_Central. # GO_process GO:0016226 iron-sulfur cluster assembly; IDA:EcoCyc. # GO_process GO:0044571 [2Fe-2S] cluster assembly; IBA:GO_Central. # GO_process GO:0097428 protein maturation by iron-sulfur cluster transfer; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0042592 homeostatic process # GOslim_process GO:0051186 cofactor metabolic process # GOslim_process GO:0051604 protein maturation # INTERACTION ISCU_ECOLI Self; NbExp=5; IntAct=EBI-561646, EBI-561646; P0A6B7 iscS; NbExp=8; IntAct=EBI-561646, EBI-550055; # IntAct P0ACD4 15 # InterPro IPR002871 NIF_FeS_clus_asmbl_NifU_N # InterPro IPR011339 ISC_FeS_clus_asmbl_IscU # Organism ISCU_ECOLI Escherichia coli (strain K12) # PATRIC 32120455 VBIEscCol129921_2630 # PDB 2KQK NMR; -; A=1-128 # PDB 2L4X NMR; -; A=1-128 # PIR H65029 H65029 # Pfam PF01592 NifU_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ISCU_ECOLI Iron-sulfur cluster assembly scaffold protein IscU # RefSeq NP_417024 NC_000913.3 # RefSeq WP_000331707 NZ_LN832404.1 # SIMILARITY Belongs to the NifU family. {ECO 0000305}. # SUBUNIT ISCU_ECOLI Homodimer. Forms a heterotetramer with IscS; each subunit of the IscS dimer contacts an IscU monomer. {ECO 0000269|PubMed 11577100, ECO 0000269|PubMed 22203963}. # TIGRFAMs TIGR01999 iscU # eggNOG COG0822 LUCA # eggNOG ENOG4107XTC Bacteria BLAST swissprot:ISCU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ISCU_ECOLI BioCyc ECOL316407:JW2513-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2513-MONOMER BioCyc EcoCyc:G7324-MONOMER http://biocyc.org/getid?id=EcoCyc:G7324-MONOMER BioCyc MetaCyc:G7324-MONOMER http://biocyc.org/getid?id=MetaCyc:G7324-MONOMER COG COG0822 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0822 DIP DIP-48025N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48025N DOI 10.1021/bi300579p http://dx.doi.org/10.1021/bi300579p DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.1114372109 http://dx.doi.org/10.1073/pnas.1114372109 DOI 10.1074/jbc.M106907200 http://dx.doi.org/10.1074/jbc.M106907200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3176 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3176 EcoGene EG13395 http://www.ecogene.org/geneInfo.php?eg_id=EG13395 EnsemblBacteria AAC75582 http://www.ensemblgenomes.org/id/AAC75582 EnsemblBacteria AAC75582 http://www.ensemblgenomes.org/id/AAC75582 EnsemblBacteria BAA16423 http://www.ensemblgenomes.org/id/BAA16423 EnsemblBacteria BAA16423 http://www.ensemblgenomes.org/id/BAA16423 EnsemblBacteria BAA16423 http://www.ensemblgenomes.org/id/BAA16423 EnsemblBacteria b2529 http://www.ensemblgenomes.org/id/b2529 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008198 GO_function GO:0036455 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036455 GO_function GO:0051537 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051537 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0006879 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006879 GO_process GO:0016226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016226 GO_process GO:0044571 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044571 GO_process GO:0097428 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097428 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GOslim_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 GeneID 947002 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947002 HOGENOM HOG000069228 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000069228&db=HOGENOM6 InParanoid P0ACD4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACD4 IntAct P0ACD4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACD4* InterPro IPR002871 http://www.ebi.ac.uk/interpro/entry/IPR002871 InterPro IPR011339 http://www.ebi.ac.uk/interpro/entry/IPR011339 KEGG_Gene ecj:JW2513 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2513 KEGG_Gene eco:b2529 http://www.genome.jp/dbget-bin/www_bget?eco:b2529 KEGG_Orthology KO:K04488 http://www.genome.jp/dbget-bin/www_bget?KO:K04488 OMA ECGDVMR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ECGDVMR PDB 2KQK http://www.ebi.ac.uk/pdbe-srv/view/entry/2KQK PDB 2L4X http://www.ebi.ac.uk/pdbe-srv/view/entry/2L4X PDBsum 2KQK http://www.ebi.ac.uk/pdbsum/2KQK PDBsum 2L4X http://www.ebi.ac.uk/pdbsum/2L4X PSORT swissprot:ISCU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ISCU_ECOLI PSORT-B swissprot:ISCU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ISCU_ECOLI PSORT2 swissprot:ISCU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ISCU_ECOLI Pfam PF01592 http://pfam.xfam.org/family/PF01592 Phobius swissprot:ISCU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ISCU_ECOLI PhylomeDB P0ACD4 http://phylomedb.org/?seqid=P0ACD4 ProteinModelPortal P0ACD4 http://www.proteinmodelportal.org/query/uniprot/P0ACD4 PubMed 11577100 http://www.ncbi.nlm.nih.gov/pubmed/11577100 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22203963 http://www.ncbi.nlm.nih.gov/pubmed/22203963 PubMed 22734684 http://www.ncbi.nlm.nih.gov/pubmed/22734684 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417024 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417024 RefSeq WP_000331707 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000331707 SMR P0ACD4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACD4 STRING 511145.b2529 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2529&targetmode=cogs STRING COG0822 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0822&targetmode=cogs TIGRFAMs TIGR01999 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01999 UniProtKB ISCU_ECOLI http://www.uniprot.org/uniprot/ISCU_ECOLI UniProtKB-AC P0ACD4 http://www.uniprot.org/uniprot/P0ACD4 charge swissprot:ISCU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ISCU_ECOLI eggNOG COG0822 http://eggnogapi.embl.de/nog_data/html/tree/COG0822 eggNOG ENOG4107XTC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107XTC epestfind swissprot:ISCU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ISCU_ECOLI garnier swissprot:ISCU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ISCU_ECOLI helixturnhelix swissprot:ISCU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ISCU_ECOLI hmoment swissprot:ISCU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ISCU_ECOLI iep swissprot:ISCU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ISCU_ECOLI inforesidue swissprot:ISCU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ISCU_ECOLI octanol swissprot:ISCU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ISCU_ECOLI pepcoil swissprot:ISCU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ISCU_ECOLI pepdigest swissprot:ISCU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ISCU_ECOLI pepinfo swissprot:ISCU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ISCU_ECOLI pepnet swissprot:ISCU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ISCU_ECOLI pepstats swissprot:ISCU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ISCU_ECOLI pepwheel swissprot:ISCU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ISCU_ECOLI pepwindow swissprot:ISCU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ISCU_ECOLI sigcleave swissprot:ISCU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ISCU_ECOLI ## Database ID URL or Descriptions # AltName MCP1_ECOLI Serine chemoreceptor protein # BioGrid 4261744 200 # CDD cd00181 Tar_Tsr_LBD # CDD cd06225 HAMP # EcoGene EG11034 tsr # FUNCTION MCP1_ECOLI Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. Attractants increase the level of methylation while repellents decrease the level of methylation, the methyl groups are added by the methyltransferase CheR and removed by the methylesterase CheB. # FUNCTION MCP1_ECOLI Receptor for the attractant L-serine and related amino acids. Is also responsible for chemotaxis away from a wide range of repellents, including leucine, indole, and weak acids. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_function GO:0004888 transmembrane signaling receptor activity; IMP:EcoCyc. # GO_function GO:0043424 protein histidine kinase binding; IDA:EcoCyc. # GO_process GO:0006935 chemotaxis; IMP:CACAO. # GO_process GO:0007165 signal transduction; IMP:CACAO. # GO_process GO:0043200 response to amino acid; IMP:EcoCyc. # GO_process GO:0048870 cell motility; IMP:CACAO. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0019899 enzyme binding # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0040011 locomotion # GOslim_process GO:0048870 cell motility # Gene3D 1.20.120.30 -; 1. # IntAct P02942 4 # InterPro IPR003122 Chemotax_Me-accpt_rcpt_lig-bd # InterPro IPR003660 HAMP_dom # InterPro IPR004089 MCPsignal_dom # InterPro IPR004090 Chemotax_Me-accpt_rcpt # InterPro IPR004091 Chemotax_Me-accpt_rcpt_Me-site # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Pathway ko02020 Two-component system # KEGG_Pathway ko02030 Bacterial chemotaxis # Organism MCP1_ECOLI Escherichia coli (strain K12) # PATRIC 32124316 VBIEscCol129921_4501 # PDB 1QU7 X-ray; 2.60 A; A/B=294-520 # PDB 2D4U X-ray; 1.95 A; A/B=25-190 # PDB 3ATP X-ray; 2.50 A; A/B=25-190 # PDB 3ZX6 X-ray; 2.65 A; A/B=264-551 # PIR E65250 QRECS # PRINTS PR00260 CHEMTRNSDUCR # PROSITE PS00538 CHEMOTAXIS_TRANSDUC_1 # PROSITE PS50111 CHEMOTAXIS_TRANSDUC_2 # PROSITE PS50885 HAMP # Pfam PF00015 MCPsignal # Pfam PF00672 HAMP # Pfam PF02203 TarH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MCP1_ECOLI Methyl-accepting chemotaxis protein I # RefSeq NP_418775 NC_000913.3 # RefSeq WP_000919536 NZ_LN832404.1 # SIMILARITY Contains 1 HAMP domain. {ECO:0000255|PROSITE- ProRule PRU00102}. # SIMILARITY Contains 1 methyl-accepting transducer domain. {ECO:0000255|PROSITE-ProRule PRU00284}. # SMART SM00283 MA # SMART SM00304 HAMP # SMART SM00319 TarH # SUBCELLULAR LOCATION MCP1_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 22380631}; Multi- pass membrane protein {ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 22380631}. Note=Found predominantly at cell poles. # SUPFAM SSF47170 SSF47170 # eggNOG COG0840 LUCA # eggNOG ENOG4105C8Q Bacteria BLAST swissprot:MCP1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MCP1_ECOLI BioCyc ECOL316407:JW4318-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4318-MONOMER BioCyc EcoCyc:TSR-MONOMER http://biocyc.org/getid?id=EcoCyc:TSR-MONOMER COG COG0840 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0840 DIP DIP-11046N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11046N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1007/BF00282806 http://dx.doi.org/10.1007/BF00282806 DOI 10.1038/23512 http://dx.doi.org/10.1038/23512 DOI 10.1038/301623a0 http://dx.doi.org/10.1038/301623a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1111/j.1365-2958.2012.08021.x http://dx.doi.org/10.1111/j.1365-2958.2012.08021.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DisProt DP00300 http://www.disprot.org/protein.php?id=DP00300 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL S56952 http://www.ebi.ac.uk/ena/data/view/S56952 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL V00373 http://www.ebi.ac.uk/ena/data/view/V00373 EchoBASE EB1027 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1027 EcoGene EG11034 http://www.ecogene.org/geneInfo.php?eg_id=EG11034 EnsemblBacteria AAC77311 http://www.ensemblgenomes.org/id/AAC77311 EnsemblBacteria AAC77311 http://www.ensemblgenomes.org/id/AAC77311 EnsemblBacteria BAE78345 http://www.ensemblgenomes.org/id/BAE78345 EnsemblBacteria BAE78345 http://www.ensemblgenomes.org/id/BAE78345 EnsemblBacteria BAE78345 http://www.ensemblgenomes.org/id/BAE78345 EnsemblBacteria b4355 http://www.ensemblgenomes.org/id/b4355 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0004888 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004888 GO_function GO:0043424 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043424 GO_process GO:0006935 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006935 GO_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GO_process GO:0043200 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043200 GO_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0019899 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0040011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 Gene3D 1.20.120.30 http://www.cathdb.info/version/latest/superfamily/1.20.120.30 GeneID 948884 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948884 HOGENOM HOG000148074 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000148074&db=HOGENOM6 InParanoid P02942 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P02942 IntAct P02942 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P02942* InterPro IPR003122 http://www.ebi.ac.uk/interpro/entry/IPR003122 InterPro IPR003660 http://www.ebi.ac.uk/interpro/entry/IPR003660 InterPro IPR004089 http://www.ebi.ac.uk/interpro/entry/IPR004089 InterPro IPR004090 http://www.ebi.ac.uk/interpro/entry/IPR004090 InterPro IPR004091 http://www.ebi.ac.uk/interpro/entry/IPR004091 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW4318 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4318 KEGG_Gene eco:b4355 http://www.genome.jp/dbget-bin/www_bget?eco:b4355 KEGG_Orthology KO:K05874 http://www.genome.jp/dbget-bin/www_bget?KO:K05874 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 KEGG_Pathway ko02030 http://www.genome.jp/kegg-bin/show_pathway?ko02030 MINT MINT-1306492 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1306492 OMA NALKHDK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NALKHDK PDB 1QU7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1QU7 PDB 2D4U http://www.ebi.ac.uk/pdbe-srv/view/entry/2D4U PDB 3ATP http://www.ebi.ac.uk/pdbe-srv/view/entry/3ATP PDB 3ZX6 http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZX6 PDBsum 1QU7 http://www.ebi.ac.uk/pdbsum/1QU7 PDBsum 2D4U http://www.ebi.ac.uk/pdbsum/2D4U PDBsum 3ATP http://www.ebi.ac.uk/pdbsum/3ATP PDBsum 3ZX6 http://www.ebi.ac.uk/pdbsum/3ZX6 PRINTS PR00260 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00260 PROSITE PS00538 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00538 PROSITE PS50111 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50111 PROSITE PS50885 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50885 PSORT swissprot:MCP1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MCP1_ECOLI PSORT-B swissprot:MCP1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MCP1_ECOLI PSORT2 swissprot:MCP1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MCP1_ECOLI Pfam PF00015 http://pfam.xfam.org/family/PF00015 Pfam PF00672 http://pfam.xfam.org/family/PF00672 Pfam PF02203 http://pfam.xfam.org/family/PF02203 Phobius swissprot:MCP1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MCP1_ECOLI PhylomeDB P02942 http://phylomedb.org/?seqid=P02942 ProteinModelPortal P02942 http://www.proteinmodelportal.org/query/uniprot/P02942 PubMed 10466731 http://www.ncbi.nlm.nih.gov/pubmed/10466731 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2033064 http://www.ncbi.nlm.nih.gov/pubmed/2033064 PubMed 22380631 http://www.ncbi.nlm.nih.gov/pubmed/22380631 PubMed 6213619 http://www.ncbi.nlm.nih.gov/pubmed/6213619 PubMed 6402709 http://www.ncbi.nlm.nih.gov/pubmed/6402709 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8384293 http://www.ncbi.nlm.nih.gov/pubmed/8384293 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_418775 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418775 RefSeq WP_000919536 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000919536 SMART SM00283 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00283 SMART SM00304 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00304 SMART SM00319 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00319 SMR P02942 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P02942 STRING 511145.b4355 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4355&targetmode=cogs STRING COG0840 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0840&targetmode=cogs SUPFAM SSF47170 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47170 UniProtKB MCP1_ECOLI http://www.uniprot.org/uniprot/MCP1_ECOLI UniProtKB-AC P02942 http://www.uniprot.org/uniprot/P02942 charge swissprot:MCP1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MCP1_ECOLI eggNOG COG0840 http://eggnogapi.embl.de/nog_data/html/tree/COG0840 eggNOG ENOG4105C8Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C8Q epestfind swissprot:MCP1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MCP1_ECOLI garnier swissprot:MCP1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MCP1_ECOLI helixturnhelix swissprot:MCP1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MCP1_ECOLI hmoment swissprot:MCP1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MCP1_ECOLI iep swissprot:MCP1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MCP1_ECOLI inforesidue swissprot:MCP1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MCP1_ECOLI octanol swissprot:MCP1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MCP1_ECOLI pepcoil swissprot:MCP1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MCP1_ECOLI pepdigest swissprot:MCP1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MCP1_ECOLI pepinfo swissprot:MCP1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MCP1_ECOLI pepnet swissprot:MCP1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MCP1_ECOLI pepstats swissprot:MCP1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MCP1_ECOLI pepwheel swissprot:MCP1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MCP1_ECOLI pepwindow swissprot:MCP1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MCP1_ECOLI sigcleave swissprot:MCP1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MCP1_ECOLI ## Database ID URL or Descriptions # AltName Alpha,alpha-trehalase {ECO:0000255|HAMAP-Rule MF_01060} # AltName Alpha,alpha-trehalose glucohydrolase {ECO:0000255|HAMAP-Rule MF_01060} # BRENDA 3.2.1.28 2026 # BioGrid 4260095 121 # CATALYTIC ACTIVITY TREA_ECOLI Alpha,alpha-trehalose + H(2)O = beta-D-glucose + alpha-D-glucose. {ECO 0000255|HAMAP-Rule MF_01060, ECO 0000269|PubMed 17455176, ECO 0000269|PubMed 19123216}. # CAZy GH37 Glycoside Hydrolase Family 37 # EcoGene EG11017 treA # FUNCTION TREA_ECOLI Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0004555 alpha,alpha-trehalase activity; IDA:UniProtKB. # GO_process GO:0005993 trehalose catabolic process; IDA:UniProtKB. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0071474 cellular hyperosmotic response; IEP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009056 catabolic process # HAMAP MF_01060 Peripl_trehalase # INDUCTION TREA_ECOLI By growth at high osmolarity, is regulated by cAMP. # IntAct P13482 5 # InterPro IPR001661 Glyco_hydro_37 # InterPro IPR008928 6-hairpin_glycosidase-like # InterPro IPR018232 Glyco_hydro_37_CS # InterPro IPR023720 Trehalase_periplasmic # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00500 Starch and sucrose metabolism # Organism TREA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR23403 PTHR23403 # PATRIC 32117642 VBIEscCol129921_1243 # PDB 2JF4 X-ray; 2.20 A; A=31-565 # PDB 2JG0 X-ray; 1.50 A; A=31-565 # PDB 2JJB X-ray; 1.90 A; A/B/C/D=31-565 # PDB 2WYN X-ray; 2.10 A; A/B/C/D=31-565 # PIR S04782 S04782 # PRINTS PR00744 GLHYDRLASE37 # PROSITE PS00927 TREHALASE_1 # PROSITE PS00928 TREHALASE_2 # Pfam PF01204 Trehalase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Periplasmic trehalase {ECO:0000255|HAMAP-Rule MF_01060} # RefSeq NP_415715 NC_000913.3 # RefSeq WP_000841714 NZ_LN832404.1 # SIMILARITY Belongs to the glycosyl hydrolase 37 family. {ECO:0000255|HAMAP-Rule MF_01060}. # SUBCELLULAR LOCATION TREA_ECOLI Periplasm. # SUBUNIT Monomer. {ECO:0000305|PubMed 19123216}. # SUPFAM SSF48208 SSF48208 # eggNOG COG1626 LUCA # eggNOG ENOG4105E53 Bacteria BLAST swissprot:TREA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TREA_ECOLI BioCyc ECOL316407:JW1186-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1186-MONOMER BioCyc EcoCyc:TREHALAPERI-MONOMER http://biocyc.org/getid?id=EcoCyc:TREHALAPERI-MONOMER BioCyc MetaCyc:TREHALAPERI-MONOMER http://biocyc.org/getid?id=MetaCyc:TREHALAPERI-MONOMER COG COG1626 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1626 DIP DIP-11022N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11022N DOI 10.1002/anie.200604825 http://dx.doi.org/10.1002/anie.200604825 DOI 10.1002/chem.200801578 http://dx.doi.org/10.1002/chem.200801578 DOI 10.1007/BF02464903 http://dx.doi.org/10.1007/BF02464903 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1991.tb00745.x http://dx.doi.org/10.1111/j.1365-2958.1991.tb00745.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.2.1.28 {ECO:0000255|HAMAP-Rule:MF_01060} http://www.genome.jp/dbget-bin/www_bget?EC:3.2.1.28 {ECO:0000255|HAMAP-Rule:MF_01060} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X15868 http://www.ebi.ac.uk/ena/data/view/X15868 ENZYME 3.2.1.28 {ECO:0000255|HAMAP-Rule:MF_01060} http://enzyme.expasy.org/EC/3.2.1.28 {ECO:0000255|HAMAP-Rule:MF_01060} EchoBASE EB1010 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1010 EcoGene EG11017 http://www.ecogene.org/geneInfo.php?eg_id=EG11017 EnsemblBacteria AAC74281 http://www.ensemblgenomes.org/id/AAC74281 EnsemblBacteria AAC74281 http://www.ensemblgenomes.org/id/AAC74281 EnsemblBacteria BAA36054 http://www.ensemblgenomes.org/id/BAA36054 EnsemblBacteria BAA36054 http://www.ensemblgenomes.org/id/BAA36054 EnsemblBacteria BAA36054 http://www.ensemblgenomes.org/id/BAA36054 EnsemblBacteria b1197 http://www.ensemblgenomes.org/id/b1197 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0004555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004555 GO_process GO:0005993 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005993 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0071474 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071474 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GeneID 945757 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945757 HAMAP MF_01060 http://hamap.expasy.org/unirule/MF_01060 HOGENOM HOG000215464 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000215464&db=HOGENOM6 InParanoid P13482 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P13482 IntAct P13482 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P13482* IntEnz 3.2.1.28 {ECO:0000255|HAMAP-Rule:MF_01060} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.2.1.28 {ECO:0000255|HAMAP-Rule:MF_01060} InterPro IPR001661 http://www.ebi.ac.uk/interpro/entry/IPR001661 InterPro IPR008928 http://www.ebi.ac.uk/interpro/entry/IPR008928 InterPro IPR018232 http://www.ebi.ac.uk/interpro/entry/IPR018232 InterPro IPR023720 http://www.ebi.ac.uk/interpro/entry/IPR023720 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1186 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1186 KEGG_Gene eco:b1197 http://www.genome.jp/dbget-bin/www_bget?eco:b1197 KEGG_Orthology KO:K01194 http://www.genome.jp/dbget-bin/www_bget?KO:K01194 KEGG_Pathway ko00500 http://www.genome.jp/kegg-bin/show_pathway?ko00500 KEGG_Reaction rn:R00010 http://www.genome.jp/dbget-bin/www_bget?rn:R00010 OMA WAGQLHQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WAGQLHQ PANTHER PTHR23403 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23403 PDB 2JF4 http://www.ebi.ac.uk/pdbe-srv/view/entry/2JF4 PDB 2JG0 http://www.ebi.ac.uk/pdbe-srv/view/entry/2JG0 PDB 2JJB http://www.ebi.ac.uk/pdbe-srv/view/entry/2JJB PDB 2WYN http://www.ebi.ac.uk/pdbe-srv/view/entry/2WYN PDBsum 2JF4 http://www.ebi.ac.uk/pdbsum/2JF4 PDBsum 2JG0 http://www.ebi.ac.uk/pdbsum/2JG0 PDBsum 2JJB http://www.ebi.ac.uk/pdbsum/2JJB PDBsum 2WYN http://www.ebi.ac.uk/pdbsum/2WYN PRINTS PR00744 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00744 PROSITE PS00927 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00927 PROSITE PS00928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00928 PSORT swissprot:TREA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TREA_ECOLI PSORT-B swissprot:TREA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TREA_ECOLI PSORT2 swissprot:TREA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TREA_ECOLI Pfam PF01204 http://pfam.xfam.org/family/PF01204 Phobius swissprot:TREA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TREA_ECOLI PhylomeDB P13482 http://phylomedb.org/?seqid=P13482 ProteinModelPortal P13482 http://www.proteinmodelportal.org/query/uniprot/P13482 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1710760 http://www.ncbi.nlm.nih.gov/pubmed/1710760 PubMed 17455176 http://www.ncbi.nlm.nih.gov/pubmed/17455176 PubMed 19123216 http://www.ncbi.nlm.nih.gov/pubmed/19123216 PubMed 2671658 http://www.ncbi.nlm.nih.gov/pubmed/2671658 PubMed 2820965 http://www.ncbi.nlm.nih.gov/pubmed/2820965 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415715 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415715 RefSeq WP_000841714 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000841714 SMR P13482 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P13482 STRING 511145.b1197 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1197&targetmode=cogs STRING COG1626 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1626&targetmode=cogs SUPFAM SSF48208 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48208 UniProtKB TREA_ECOLI http://www.uniprot.org/uniprot/TREA_ECOLI UniProtKB-AC P13482 http://www.uniprot.org/uniprot/P13482 charge swissprot:TREA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TREA_ECOLI eggNOG COG1626 http://eggnogapi.embl.de/nog_data/html/tree/COG1626 eggNOG ENOG4105E53 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E53 epestfind swissprot:TREA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TREA_ECOLI garnier swissprot:TREA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TREA_ECOLI helixturnhelix swissprot:TREA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TREA_ECOLI hmoment swissprot:TREA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TREA_ECOLI iep swissprot:TREA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TREA_ECOLI inforesidue swissprot:TREA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TREA_ECOLI octanol swissprot:TREA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TREA_ECOLI pepcoil swissprot:TREA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TREA_ECOLI pepdigest swissprot:TREA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TREA_ECOLI pepinfo swissprot:TREA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TREA_ECOLI pepnet swissprot:TREA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TREA_ECOLI pepstats swissprot:TREA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TREA_ECOLI pepwheel swissprot:TREA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TREA_ECOLI pepwindow swissprot:TREA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TREA_ECOLI sigcleave swissprot:TREA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TREA_ECOLI ## Database ID URL or Descriptions # BioGrid 4263183 8 # CDD cd06174 MFS # EcoGene EG10177 cynX # FUNCTION CYNX_ECOLI This protein is part of an active transport system that transports exogenous cyanate into E.coli cells. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0009440 cyanate catabolic process; IEP:EcoCyc. # GO_process GO:0055085 transmembrane transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0055085 transmembrane transport # InterPro IPR004747 Cyan_transport # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # KEGG_Brite ko02000 Transporters # Organism CYNX_ECOLI Escherichia coli (strain K12) # PATRIC 32115815 VBIEscCol129921_0349 # PIR E64761 BVECCX # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CYNX_ECOLI Cyanate transport protein CynX # RefSeq NP_414875 NC_000913.3 # SEQUENCE CAUTION Sequence=AAB18065.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the major facilitator superfamily. Cyanate porter (TC 2.A.1.17) family. {ECO 0000305}. # SUBCELLULAR LOCATION CYNX_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.17 the major facilitator superfamily (mfs) # TIGRFAMs TIGR00896 CynX # eggNOG COG2807 LUCA # eggNOG ENOG4105DJ2 Bacteria BLAST swissprot:CYNX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CYNX_ECOLI BioCyc ECOL316407:JW0332-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0332-MONOMER BioCyc EcoCyc:CYNX-MONOMER http://biocyc.org/getid?id=EcoCyc:CYNX-MONOMER COG COG2807 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M23219 http://www.ebi.ac.uk/ena/data/view/M23219 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB0174 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0174 EcoGene EG10177 http://www.ecogene.org/geneInfo.php?eg_id=EG10177 EnsemblBacteria AAC73444 http://www.ensemblgenomes.org/id/AAC73444 EnsemblBacteria AAC73444 http://www.ensemblgenomes.org/id/AAC73444 EnsemblBacteria BAE76123 http://www.ensemblgenomes.org/id/BAE76123 EnsemblBacteria BAE76123 http://www.ensemblgenomes.org/id/BAE76123 EnsemblBacteria BAE76123 http://www.ensemblgenomes.org/id/BAE76123 EnsemblBacteria b0341 http://www.ensemblgenomes.org/id/b0341 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0009440 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009440 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 946770 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946770 HOGENOM HOG000273879 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000273879&db=HOGENOM6 InParanoid P17583 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P17583 InterPro IPR004747 http://www.ebi.ac.uk/interpro/entry/IPR004747 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0332 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0332 KEGG_Gene eco:b0341 http://www.genome.jp/dbget-bin/www_bget?eco:b0341 KEGG_Orthology KO:K03449 http://www.genome.jp/dbget-bin/www_bget?KO:K03449 OMA GYIMGGF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GYIMGGF PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:CYNX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CYNX_ECOLI PSORT-B swissprot:CYNX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CYNX_ECOLI PSORT2 swissprot:CYNX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CYNX_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:CYNX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CYNX_ECOLI PhylomeDB P17583 http://phylomedb.org/?seqid=P17583 ProteinModelPortal P17583 http://www.proteinmodelportal.org/query/uniprot/P17583 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3049588 http://www.ncbi.nlm.nih.gov/pubmed/3049588 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414875 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414875 STRING 511145.b0341 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0341&targetmode=cogs STRING COG2807 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2807&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.17 http://www.tcdb.org/search/result.php?tc=2.A.1.17 TIGRFAMs TIGR00896 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00896 UniProtKB CYNX_ECOLI http://www.uniprot.org/uniprot/CYNX_ECOLI UniProtKB-AC P17583 http://www.uniprot.org/uniprot/P17583 charge swissprot:CYNX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CYNX_ECOLI eggNOG COG2807 http://eggnogapi.embl.de/nog_data/html/tree/COG2807 eggNOG ENOG4105DJ2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DJ2 epestfind swissprot:CYNX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CYNX_ECOLI garnier swissprot:CYNX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CYNX_ECOLI helixturnhelix swissprot:CYNX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CYNX_ECOLI hmoment swissprot:CYNX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CYNX_ECOLI iep swissprot:CYNX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CYNX_ECOLI inforesidue swissprot:CYNX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CYNX_ECOLI octanol swissprot:CYNX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CYNX_ECOLI pepcoil swissprot:CYNX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CYNX_ECOLI pepdigest swissprot:CYNX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CYNX_ECOLI pepinfo swissprot:CYNX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CYNX_ECOLI pepnet swissprot:CYNX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CYNX_ECOLI pepstats swissprot:CYNX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CYNX_ECOLI pepwheel swissprot:CYNX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CYNX_ECOLI pepwindow swissprot:CYNX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CYNX_ECOLI sigcleave swissprot:CYNX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CYNX_ECOLI ## Database ID URL or Descriptions # BioGrid 4263508 4 # EcoGene EG14060 yegQ # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008233 peptidase activity; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0008233 peptidase activity # IntAct P76403 8 # InterPro IPR001539 Peptidase_U32 # InterPro IPR032525 Peptidase_U32_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # KEGG_Pathway ko05120 Epithelial cell signaling in Helicobacter pylori infection # Organism YEGQ_ECOLI Escherichia coli (strain K12) # PATRIC 32119497 VBIEscCol129921_2159 # PIR H64974 H64974 # PROSITE PS01276 PEPTIDASE_U32 # Pfam PF01136 Peptidase_U32 # Pfam PF16325 Peptidase_U32_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEGQ_ECOLI Uncharacterized protease YegQ # RefSeq NP_416585 NC_000913.3 # RefSeq WP_000476011 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase U32 family. {ECO 0000305}. # eggNOG COG0826 LUCA # eggNOG ENOG4105CFP Bacteria BLAST swissprot:YEGQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEGQ_ECOLI BioCyc ECOL316407:JW2066-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2066-MONOMER BioCyc EcoCyc:G7118-MONOMER http://biocyc.org/getid?id=EcoCyc:G7118-MONOMER COG COG0826 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0826 DIP DIP-11887N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11887N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.4.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.4.-.- http://enzyme.expasy.org/EC/3.4.-.- EchoBASE EB3813 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3813 EcoGene EG14060 http://www.ecogene.org/geneInfo.php?eg_id=EG14060 EnsemblBacteria AAC75142 http://www.ensemblgenomes.org/id/AAC75142 EnsemblBacteria AAC75142 http://www.ensemblgenomes.org/id/AAC75142 EnsemblBacteria BAA15936 http://www.ensemblgenomes.org/id/BAA15936 EnsemblBacteria BAA15936 http://www.ensemblgenomes.org/id/BAA15936 EnsemblBacteria BAA15936 http://www.ensemblgenomes.org/id/BAA15936 EnsemblBacteria b2081 http://www.ensemblgenomes.org/id/b2081 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GeneID 946609 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946609 HOGENOM HOG000275241 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275241&db=HOGENOM6 InParanoid P76403 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76403 IntAct P76403 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76403* IntEnz 3.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4 InterPro IPR001539 http://www.ebi.ac.uk/interpro/entry/IPR001539 InterPro IPR032525 http://www.ebi.ac.uk/interpro/entry/IPR032525 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW2066 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2066 KEGG_Gene eco:b2081 http://www.genome.jp/dbget-bin/www_bget?eco:b2081 KEGG_Orthology KO:K08303 http://www.genome.jp/dbget-bin/www_bget?KO:K08303 KEGG_Pathway ko05120 http://www.genome.jp/kegg-bin/show_pathway?ko05120 OMA DFQVNGE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DFQVNGE PROSITE PS01276 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01276 PSORT swissprot:YEGQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEGQ_ECOLI PSORT-B swissprot:YEGQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEGQ_ECOLI PSORT2 swissprot:YEGQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEGQ_ECOLI Pfam PF01136 http://pfam.xfam.org/family/PF01136 Pfam PF16325 http://pfam.xfam.org/family/PF16325 Phobius swissprot:YEGQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEGQ_ECOLI PhylomeDB P76403 http://phylomedb.org/?seqid=P76403 ProteinModelPortal P76403 http://www.proteinmodelportal.org/query/uniprot/P76403 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416585 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416585 RefSeq WP_000476011 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000476011 SMR P76403 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76403 STRING 511145.b2081 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2081&targetmode=cogs STRING COG0826 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0826&targetmode=cogs UniProtKB YEGQ_ECOLI http://www.uniprot.org/uniprot/YEGQ_ECOLI UniProtKB-AC P76403 http://www.uniprot.org/uniprot/P76403 charge swissprot:YEGQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEGQ_ECOLI eggNOG COG0826 http://eggnogapi.embl.de/nog_data/html/tree/COG0826 eggNOG ENOG4105CFP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CFP epestfind swissprot:YEGQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEGQ_ECOLI garnier swissprot:YEGQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEGQ_ECOLI helixturnhelix swissprot:YEGQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEGQ_ECOLI hmoment swissprot:YEGQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEGQ_ECOLI iep swissprot:YEGQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEGQ_ECOLI inforesidue swissprot:YEGQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEGQ_ECOLI octanol swissprot:YEGQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEGQ_ECOLI pepcoil swissprot:YEGQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEGQ_ECOLI pepdigest swissprot:YEGQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEGQ_ECOLI pepinfo swissprot:YEGQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEGQ_ECOLI pepnet swissprot:YEGQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEGQ_ECOLI pepstats swissprot:YEGQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEGQ_ECOLI pepwheel swissprot:YEGQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEGQ_ECOLI pepwindow swissprot:YEGQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEGQ_ECOLI sigcleave swissprot:YEGQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEGQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4262284 16 # CDD cd01714 ETF_beta # DISRUPTION PHENOTYPE Cells undergo an apoptotic-like death upon DNA damage characterized by membrane depolarization. {ECO:0000269|PubMed 22412352}. # EcoGene EG13125 ygcR # FUNCTION YGCR_ECOLI May play a role in a redox process. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0009055 electron carrier activity; IBA:GO_Central. # GO_process GO:0055114 oxidation-reduction process; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.620 -; 1. # IntAct Q46908 2 # InterPro IPR012255 ETF_b # InterPro IPR014729 Rossmann-like_a/b/a_fold # InterPro IPR014730 ETF_a/b_N # InterPro IPR033948 ETF_beta_N # Organism YGCR_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21294 PTHR21294 # PATRIC 32120952 VBIEscCol129921_2868 # PIR F65058 F65058 # PIRSF PIRSF000090 Beta-ETF # Pfam PF01012 ETF # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGCR_ECOLI Putative electron transfer flavoprotein subunit YgcR # RefSeq NP_417250 NC_000913.3 # RefSeq WP_001299652 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA69280.1; Type=Frameshift; Positions=232; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ETF beta-subunit/FixA family. {ECO 0000305}. # SMART SM00893 ETF # SUBUNIT YgcQ and YgcR form a heterodimer. {ECO 0000305}. # eggNOG COG2086 LUCA # eggNOG ENOG4106IKH Bacteria BLAST swissprot:YGCR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGCR_ECOLI BioCyc ECOL316407:JW5441-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5441-MONOMER BioCyc EcoCyc:G7436-MONOMER http://biocyc.org/getid?id=EcoCyc:G7436-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pbio.1001281 http://dx.doi.org/10.1371/journal.pbio.1001281 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EchoBASE EB2926 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2926 EcoGene EG13125 http://www.ecogene.org/geneInfo.php?eg_id=EG13125 EnsemblBacteria AAC75812 http://www.ensemblgenomes.org/id/AAC75812 EnsemblBacteria AAC75812 http://www.ensemblgenomes.org/id/AAC75812 EnsemblBacteria BAE76847 http://www.ensemblgenomes.org/id/BAE76847 EnsemblBacteria BAE76847 http://www.ensemblgenomes.org/id/BAE76847 EnsemblBacteria BAE76847 http://www.ensemblgenomes.org/id/BAE76847 EnsemblBacteria b2770 http://www.ensemblgenomes.org/id/b2770 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_process GO:0055114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 GeneID 947240 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947240 HOGENOM HOG000124113 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000124113&db=HOGENOM6 InParanoid Q46908 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46908 IntAct Q46908 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46908* InterPro IPR012255 http://www.ebi.ac.uk/interpro/entry/IPR012255 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 InterPro IPR014730 http://www.ebi.ac.uk/interpro/entry/IPR014730 InterPro IPR033948 http://www.ebi.ac.uk/interpro/entry/IPR033948 KEGG_Gene ecj:JW5441 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5441 KEGG_Gene eco:b2770 http://www.genome.jp/dbget-bin/www_bget?eco:b2770 OMA QEVRMNI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QEVRMNI PANTHER PTHR21294 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21294 PSORT swissprot:YGCR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGCR_ECOLI PSORT-B swissprot:YGCR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGCR_ECOLI PSORT2 swissprot:YGCR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGCR_ECOLI Pfam PF01012 http://pfam.xfam.org/family/PF01012 Phobius swissprot:YGCR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGCR_ECOLI PhylomeDB Q46908 http://phylomedb.org/?seqid=Q46908 ProteinModelPortal Q46908 http://www.proteinmodelportal.org/query/uniprot/Q46908 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22412352 http://www.ncbi.nlm.nih.gov/pubmed/22412352 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417250 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417250 RefSeq WP_001299652 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001299652 SMART SM00893 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00893 SMR Q46908 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46908 STRING 511145.b2770 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2770&targetmode=cogs UniProtKB YGCR_ECOLI http://www.uniprot.org/uniprot/YGCR_ECOLI UniProtKB-AC Q46908 http://www.uniprot.org/uniprot/Q46908 charge swissprot:YGCR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGCR_ECOLI eggNOG COG2086 http://eggnogapi.embl.de/nog_data/html/tree/COG2086 eggNOG ENOG4106IKH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106IKH epestfind swissprot:YGCR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGCR_ECOLI garnier swissprot:YGCR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGCR_ECOLI helixturnhelix swissprot:YGCR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGCR_ECOLI hmoment swissprot:YGCR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGCR_ECOLI iep swissprot:YGCR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGCR_ECOLI inforesidue swissprot:YGCR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGCR_ECOLI octanol swissprot:YGCR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGCR_ECOLI pepcoil swissprot:YGCR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGCR_ECOLI pepdigest swissprot:YGCR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGCR_ECOLI pepinfo swissprot:YGCR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGCR_ECOLI pepnet swissprot:YGCR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGCR_ECOLI pepstats swissprot:YGCR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGCR_ECOLI pepwheel swissprot:YGCR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGCR_ECOLI pepwindow swissprot:YGCR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGCR_ECOLI sigcleave swissprot:YGCR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGCR_ECOLI ## Database ID URL or Descriptions # BioGrid 4259852 228 # DISRUPTION PHENOTYPE Mutant exhibits increased sensitivity to H(2)O(2) stress. {ECO:0000269|PubMed 24038693}. # EcoGene EG13260 fetB # FUNCTION FETB_ECOLI Part of the ABC transporter complex FetAB, which is probably involved in iron export and enhances resistance to H(2)O(2)-mediated oxidative stress. Probably responsible for the translocation of the substrate across the membrane. {ECO 0000269|PubMed 24038693}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_function GO:0015075 ion transmembrane transporter activity; IBA:GO_Central. # GO_process GO:0006879 cellular iron ion homeostasis; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0042592 homeostatic process # InterPro IPR005226 UPF0014_fam # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00211 Putative ABC transport system # KEGG_Brite ko02000 Transporters # Organism FETB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30028:SF0 PTHR30028:SF0 # PATRIC 32116141 VBIEscCol129921_0512 # Pfam PF03649 UPF0014 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FETB_ECOLI Probable iron export permease protein FetB # RefSeq NP_415024 NC_000913.3 # RefSeq WP_001295323 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40245.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the UPF0014 family. {ECO 0000305}. # SUBCELLULAR LOCATION FETB_ECOLI Cell inner membrane {ECO 0000269|PubMed 24038693}; Multi-pass membrane protein {ECO 0000269|PubMed 24038693}. # SUBUNIT The complex is composed of two ATP-binding proteins (FetA) and two transmembrane proteins (FetB). {ECO 0000250}. # TCDB 3.A.1.139 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR00245 TIGR00245 # eggNOG COG0390 LUCA # eggNOG ENOG4105C4B Bacteria BLAST swissprot:FETB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FETB_ECOLI BioCyc ECOL316407:JW5066-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5066-MONOMER BioCyc EcoCyc:G6267-MONOMER http://biocyc.org/getid?id=EcoCyc:G6267-MONOMER COG COG0390 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0390 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AEM.02322-13 http://dx.doi.org/10.1128/AEM.02322-13 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EchoBASE EB3048 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3048 EcoGene EG13260 http://www.ecogene.org/geneInfo.php?eg_id=EG13260 EnsemblBacteria AAC73593 http://www.ensemblgenomes.org/id/AAC73593 EnsemblBacteria AAC73593 http://www.ensemblgenomes.org/id/AAC73593 EnsemblBacteria BAE76270 http://www.ensemblgenomes.org/id/BAE76270 EnsemblBacteria BAE76270 http://www.ensemblgenomes.org/id/BAE76270 EnsemblBacteria BAE76270 http://www.ensemblgenomes.org/id/BAE76270 EnsemblBacteria b0491 http://www.ensemblgenomes.org/id/b0491 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015075 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015075 GO_process GO:0006879 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006879 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GeneID 945137 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945137 HOGENOM HOG000260834 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260834&db=HOGENOM6 InParanoid P77307 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77307 InterPro IPR005226 http://www.ebi.ac.uk/interpro/entry/IPR005226 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5066 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5066 KEGG_Gene eco:b0491 http://www.genome.jp/dbget-bin/www_bget?eco:b0491 KEGG_Orthology KO:K02069 http://www.genome.jp/dbget-bin/www_bget?KO:K02069 OMA PWYEPQY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PWYEPQY PANTHER PTHR30028:SF0 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30028:SF0 PSORT swissprot:FETB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FETB_ECOLI PSORT-B swissprot:FETB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FETB_ECOLI PSORT2 swissprot:FETB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FETB_ECOLI Pfam PF03649 http://pfam.xfam.org/family/PF03649 Phobius swissprot:FETB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FETB_ECOLI PhylomeDB P77307 http://phylomedb.org/?seqid=P77307 ProteinModelPortal P77307 http://www.proteinmodelportal.org/query/uniprot/P77307 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 24038693 http://www.ncbi.nlm.nih.gov/pubmed/24038693 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415024 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415024 RefSeq WP_001295323 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295323 STRING 511145.b0491 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0491&targetmode=cogs STRING COG0390 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0390&targetmode=cogs TCDB 3.A.1.139 http://www.tcdb.org/search/result.php?tc=3.A.1.139 TIGRFAMs TIGR00245 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00245 UniProtKB FETB_ECOLI http://www.uniprot.org/uniprot/FETB_ECOLI UniProtKB-AC P77307 http://www.uniprot.org/uniprot/P77307 charge swissprot:FETB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FETB_ECOLI eggNOG COG0390 http://eggnogapi.embl.de/nog_data/html/tree/COG0390 eggNOG ENOG4105C4B http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C4B epestfind swissprot:FETB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FETB_ECOLI garnier swissprot:FETB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FETB_ECOLI helixturnhelix swissprot:FETB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FETB_ECOLI hmoment swissprot:FETB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FETB_ECOLI iep swissprot:FETB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FETB_ECOLI inforesidue swissprot:FETB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FETB_ECOLI octanol swissprot:FETB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FETB_ECOLI pepcoil swissprot:FETB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FETB_ECOLI pepdigest swissprot:FETB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FETB_ECOLI pepinfo swissprot:FETB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FETB_ECOLI pepnet swissprot:FETB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FETB_ECOLI pepstats swissprot:FETB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FETB_ECOLI pepwheel swissprot:FETB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FETB_ECOLI pepwindow swissprot:FETB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FETB_ECOLI sigcleave swissprot:FETB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FETB_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES GUDD_ECOLI Kinetic parameters KM=16 uM for idarate {ECO 0000269|PubMed 9772162}; KM=60 uM for glucarate {ECO 0000269|PubMed 9772162}; # BRENDA 4.2.1.40 2026 # BioGrid 4262287 12 # CATALYTIC ACTIVITY GUDD_ECOLI D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H(2)O. # COFACTOR GUDD_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 10769114}; # DrugBank DB02325 Isopropyl Alcohol # EcoGene EG13167 gudD # FUNCTION GUDD_ECOLI Catalyzes the dehydration of glucarate to 5-keto-4- deoxy-D-glucarate (5-kdGluc). Also acts on L-idarate. # GO_function GO:0000287 magnesium ion binding; IDA:UniProtKB. # GO_function GO:0008872 glucarate dehydratase activity; IDA:UniProtKB. # GO_process GO:0042838 D-glucarate catabolic process; IDA:UniProtKB. # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.120 -; 1. # Gene3D 3.30.390.10 -; 1. # IntAct P0AES2 3 # InterPro IPR001354 MR/MLE/MAL # InterPro IPR013342 Mandelate_racemase_C # InterPro IPR017653 Glucarate_dehydratase # InterPro IPR029017 Enolase_N-like # InterPro IPR029065 Enolase_C-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00053 Ascorbate and aldarate metabolism # Organism GUDD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR13794 PTHR13794; 2 # PATHWAY Carbohydrate acid metabolism; D-glucarate degradation; 2,5-dioxopentanoate from D-glucarate step 1/2. # PATRIC 32120990 VBIEscCol129921_2887 # PDB 1EC7 X-ray; 1.90 A; A/B/C/D=1-446 # PDB 1EC8 X-ray; 1.90 A; A/B/C/D=1-446 # PDB 1EC9 X-ray; 2.00 A; A/B/C/D=1-446 # PDB 1ECQ X-ray; 2.00 A; A/B/C/D=1-446 # PDB 1JCT X-ray; 2.75 A; A/B=1-446 # PDB 1JDF X-ray; 2.00 A; A/B/C/D=1-446 # PDB 3PWG X-ray; 2.00 A; A/B/C/D=1-446 # PDB 3PWI X-ray; 2.23 A; A/B=1-446 # PDB 4GYP X-ray; 2.10 A; A/B=1-446 # PIR G65060 G65060 # Pfam PF13378 MR_MLE_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GUDD_ECOLI Glucarate dehydratase # RefSeq NP_417267 NC_000913.3 # RefSeq WP_000098255 NZ_LN832404.1 # SIMILARITY Belongs to the mandelate racemase/muconate lactonizing enzyme family. GlucD subfamily. {ECO 0000305}. # SMART SM00922 MR_MLE # SUBUNIT GUDD_ECOLI Homodimer. {ECO 0000269|PubMed 10769114, ECO 0000269|PubMed 11513584}. # SUPFAM SSF51604 SSF51604 # SUPFAM SSF54826 SSF54826 # TIGRFAMs TIGR03247 glucar-dehydr # UniPathway UPA00564 UER00627 # eggNOG COG4948 LUCA # eggNOG ENOG4105EQX Bacteria BLAST swissprot:GUDD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GUDD_ECOLI BioCyc ECOL316407:JW2758-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2758-MONOMER BioCyc EcoCyc:GLUCARDEHYDRA-MONOMER http://biocyc.org/getid?id=EcoCyc:GLUCARDEHYDRA-MONOMER BioCyc MetaCyc:GLUCARDEHYDRA-MONOMER http://biocyc.org/getid?id=MetaCyc:GLUCARDEHYDRA-MONOMER COG COG4948 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4948 DOI 10.1021/bi010733b http://dx.doi.org/10.1021/bi010733b DOI 10.1021/bi981124f http://dx.doi.org/10.1021/bi981124f DOI 10.1021/bi992782i http://dx.doi.org/10.1021/bi992782i DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB02325 http://www.drugbank.ca/drugs/DB02325 EC_number EC:4.2.1.40 http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.40 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 ENZYME 4.2.1.40 http://enzyme.expasy.org/EC/4.2.1.40 EchoBASE EB2959 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2959 EcoGene EG13167 http://www.ecogene.org/geneInfo.php?eg_id=EG13167 EnsemblBacteria AAC75829 http://www.ensemblgenomes.org/id/AAC75829 EnsemblBacteria AAC75829 http://www.ensemblgenomes.org/id/AAC75829 EnsemblBacteria BAA16572 http://www.ensemblgenomes.org/id/BAA16572 EnsemblBacteria BAA16572 http://www.ensemblgenomes.org/id/BAA16572 EnsemblBacteria BAA16572 http://www.ensemblgenomes.org/id/BAA16572 EnsemblBacteria b2787 http://www.ensemblgenomes.org/id/b2787 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0008872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008872 GO_process GO:0042838 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042838 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.120 http://www.cathdb.info/version/latest/superfamily/3.20.20.120 Gene3D 3.30.390.10 http://www.cathdb.info/version/latest/superfamily/3.30.390.10 GeneID 947258 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947258 HOGENOM HOG000238021 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000238021&db=HOGENOM6 InParanoid P0AES2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AES2 IntAct P0AES2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AES2* IntEnz 4.2.1.40 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.40 InterPro IPR001354 http://www.ebi.ac.uk/interpro/entry/IPR001354 InterPro IPR013342 http://www.ebi.ac.uk/interpro/entry/IPR013342 InterPro IPR017653 http://www.ebi.ac.uk/interpro/entry/IPR017653 InterPro IPR029017 http://www.ebi.ac.uk/interpro/entry/IPR029017 InterPro IPR029065 http://www.ebi.ac.uk/interpro/entry/IPR029065 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2758 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2758 KEGG_Gene eco:b2787 http://www.genome.jp/dbget-bin/www_bget?eco:b2787 KEGG_Orthology KO:K01706 http://www.genome.jp/dbget-bin/www_bget?KO:K01706 KEGG_Pathway ko00053 http://www.genome.jp/kegg-bin/show_pathway?ko00053 KEGG_Reaction rn:R02752 http://www.genome.jp/dbget-bin/www_bget?rn:R02752 KEGG_Reaction rn:R08056 http://www.genome.jp/dbget-bin/www_bget?rn:R08056 OMA RVAQMCN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RVAQMCN PANTHER PTHR13794 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13794 PDB 1EC7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1EC7 PDB 1EC8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1EC8 PDB 1EC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1EC9 PDB 1ECQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1ECQ PDB 1JCT http://www.ebi.ac.uk/pdbe-srv/view/entry/1JCT PDB 1JDF http://www.ebi.ac.uk/pdbe-srv/view/entry/1JDF PDB 3PWG http://www.ebi.ac.uk/pdbe-srv/view/entry/3PWG PDB 3PWI http://www.ebi.ac.uk/pdbe-srv/view/entry/3PWI PDB 4GYP http://www.ebi.ac.uk/pdbe-srv/view/entry/4GYP PDBsum 1EC7 http://www.ebi.ac.uk/pdbsum/1EC7 PDBsum 1EC8 http://www.ebi.ac.uk/pdbsum/1EC8 PDBsum 1EC9 http://www.ebi.ac.uk/pdbsum/1EC9 PDBsum 1ECQ http://www.ebi.ac.uk/pdbsum/1ECQ PDBsum 1JCT http://www.ebi.ac.uk/pdbsum/1JCT PDBsum 1JDF http://www.ebi.ac.uk/pdbsum/1JDF PDBsum 3PWG http://www.ebi.ac.uk/pdbsum/3PWG PDBsum 3PWI http://www.ebi.ac.uk/pdbsum/3PWI PDBsum 4GYP http://www.ebi.ac.uk/pdbsum/4GYP PSORT swissprot:GUDD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GUDD_ECOLI PSORT-B swissprot:GUDD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GUDD_ECOLI PSORT2 swissprot:GUDD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GUDD_ECOLI Pfam PF13378 http://pfam.xfam.org/family/PF13378 Phobius swissprot:GUDD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GUDD_ECOLI PhylomeDB P0AES2 http://phylomedb.org/?seqid=P0AES2 ProteinModelPortal P0AES2 http://www.proteinmodelportal.org/query/uniprot/P0AES2 PubMed 10769114 http://www.ncbi.nlm.nih.gov/pubmed/10769114 PubMed 11513584 http://www.ncbi.nlm.nih.gov/pubmed/11513584 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9772162 http://www.ncbi.nlm.nih.gov/pubmed/9772162 RefSeq NP_417267 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417267 RefSeq WP_000098255 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000098255 SMART SM00922 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00922 SMR P0AES2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AES2 STRING 511145.b2787 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2787&targetmode=cogs STRING COG4948 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4948&targetmode=cogs SUPFAM SSF51604 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51604 SUPFAM SSF54826 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54826 TIGRFAMs TIGR03247 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03247 UniProtKB GUDD_ECOLI http://www.uniprot.org/uniprot/GUDD_ECOLI UniProtKB-AC P0AES2 http://www.uniprot.org/uniprot/P0AES2 charge swissprot:GUDD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GUDD_ECOLI eggNOG COG4948 http://eggnogapi.embl.de/nog_data/html/tree/COG4948 eggNOG ENOG4105EQX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EQX epestfind swissprot:GUDD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GUDD_ECOLI garnier swissprot:GUDD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GUDD_ECOLI helixturnhelix swissprot:GUDD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GUDD_ECOLI hmoment swissprot:GUDD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GUDD_ECOLI iep swissprot:GUDD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GUDD_ECOLI inforesidue swissprot:GUDD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GUDD_ECOLI octanol swissprot:GUDD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GUDD_ECOLI pepcoil swissprot:GUDD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GUDD_ECOLI pepdigest swissprot:GUDD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GUDD_ECOLI pepinfo swissprot:GUDD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GUDD_ECOLI pepnet swissprot:GUDD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GUDD_ECOLI pepstats swissprot:GUDD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GUDD_ECOLI pepwheel swissprot:GUDD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GUDD_ECOLI pepwindow swissprot:GUDD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GUDD_ECOLI sigcleave swissprot:GUDD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GUDD_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=16.94 uM for succinate semialdehyde {ECO 0000269|PubMed:20174634}; Note=The enzyme activity measured in the presence of NADP(+) is approximately 20-fold higher than that measured in the presence of NAD(+).; # BRENDA 1.2.1.79 2026 # BioGrid 4259209 15 # CATALYTIC ACTIVITY Succinate semialdehyde + NADP(+) + H(2)O = succinate + NADPH. {ECO:0000269|PubMed 20174634}. # EcoGene EG11329 gabD # FUNCTION GABD_ECOLI Catalyzes the NADP(+)-dependent oxidation of succinate semialdehyde to succinate. It appears to be important for nitrogen metabolism under N limitation conditions. {ECO 0000269|PubMed 20174634, ECO 0000269|PubMed 7011797}. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_function GO:0004029 aldehyde dehydrogenase (NAD) activity; IBA:GO_Central. # GO_function GO:0004777 succinate-semialdehyde dehydrogenase (NAD+) activity; IDA:UniProtKB. # GO_function GO:0009013 succinate-semialdehyde dehydrogenase [NAD(P)+] activity; IDA:UniProtKB. # GO_process GO:0006807 nitrogen compound metabolic process; IDA:UniProtKB. # GO_process GO:0009450 gamma-aminobutyric acid catabolic process; IDA:UniProtKB. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # Gene3D 3.40.309.10 -; 1. # Gene3D 3.40.605.10 -; 1. # INDUCTION GABD_ECOLI Induced by RpoS in response to multiple stress conditions, including shifts to acidic pH, nitrogen limitation or high osmolarity as well as starvation or stationary phase. Induced by gamma-aminobutyrate (GABA). {ECO 0000269|PubMed 14731280, ECO 0000269|PubMed 7011797}. # IntAct P25526 2 # InterPro IPR010102 Succ_semiAld_DH # InterPro IPR015590 Aldehyde_DH_dom # InterPro IPR016160 Ald_DH_CS_CYS # InterPro IPR016161 Ald_DH/histidinol_DH # InterPro IPR016162 Ald_DH_N # InterPro IPR016163 Ald_DH_C # InterPro IPR029510 Ald_DH_CS_GLU # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00250 Alanine, aspartate and glutamate metabolism # KEGG_Pathway ko00350 Tyrosine metabolism # KEGG_Pathway ko00650 Butanoate metabolism # Organism GABD_ECOLI Escherichia coli (strain K12) # PATHWAY GABD_ECOLI Amino-acid degradation; 4-aminobutanoate degradation. # PATRIC 32120712 VBIEscCol129921_2753 # PDB 3JZ4 X-ray; 2.30 A; A/B/C/D=2-482 # PIR F65045 F65045 # PROSITE PS00070 ALDEHYDE_DEHYDR_CYS # PROSITE PS00687 ALDEHYDE_DEHYDR_GLU # Pfam PF00171 Aldedh # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GABD_ECOLI Succinate-semialdehyde dehydrogenase [NADP(+)] GabD # RefSeq NP_417147 NC_000913.3 # RefSeq WP_000772831 NZ_LN832404.1 # SIMILARITY Belongs to the aldehyde dehydrogenase family. {ECO 0000305}. # SUBUNIT Homotetramer. {ECO:0000269|PubMed 20174634}. # SUPFAM SSF53720 SSF53720 # TIGRFAMs TIGR01780 SSADH # eggNOG COG1012 LUCA # eggNOG ENOG4105C26 Bacteria BLAST swissprot:GABD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GABD_ECOLI BioCyc ECOL316407:JW2636-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2636-MONOMER BioCyc EcoCyc:SUCCSEMIALDDEHYDROG-MONOMER http://biocyc.org/getid?id=EcoCyc:SUCCSEMIALDDEHYDROG-MONOMER BioCyc MetaCyc:SUCCSEMIALDDEHYDROG-MONOMER http://biocyc.org/getid?id=MetaCyc:SUCCSEMIALDDEHYDROG-MONOMER COG COG1012 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1012 DIP DIP-9723N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9723N DOI 10.1007/BF00245306 http://dx.doi.org/10.1007/BF00245306 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2003.03867.x http://dx.doi.org/10.1046/j.1365-2958.2003.03867.x DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1432-1033.1981.tb05098.x http://dx.doi.org/10.1111/j.1432-1033.1981.tb05098.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pone.0009280 http://dx.doi.org/10.1371/journal.pone.0009280 EC_number EC:1.2.1.79 http://www.genome.jp/dbget-bin/www_bget?EC:1.2.1.79 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M88334 http://www.ebi.ac.uk/ena/data/view/M88334 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.2.1.79 http://enzyme.expasy.org/EC/1.2.1.79 EchoBASE EB1305 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1305 EcoGene EG11329 http://www.ecogene.org/geneInfo.php?eg_id=EG11329 EnsemblBacteria AAC75708 http://www.ensemblgenomes.org/id/AAC75708 EnsemblBacteria AAC75708 http://www.ensemblgenomes.org/id/AAC75708 EnsemblBacteria BAA16524 http://www.ensemblgenomes.org/id/BAA16524 EnsemblBacteria BAA16524 http://www.ensemblgenomes.org/id/BAA16524 EnsemblBacteria BAA16524 http://www.ensemblgenomes.org/id/BAA16524 EnsemblBacteria b2661 http://www.ensemblgenomes.org/id/b2661 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004029 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004029 GO_function GO:0004777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004777 GO_function GO:0009013 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009013 GO_process GO:0006807 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006807 GO_process GO:0009450 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009450 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 3.40.309.10 http://www.cathdb.info/version/latest/superfamily/3.40.309.10 Gene3D 3.40.605.10 http://www.cathdb.info/version/latest/superfamily/3.40.605.10 GeneID 948060 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948060 HOGENOM HOG000271509 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000271509&db=HOGENOM6 InParanoid P25526 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P25526 IntAct P25526 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P25526* IntEnz 1.2.1.79 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.2.1.79 InterPro IPR010102 http://www.ebi.ac.uk/interpro/entry/IPR010102 InterPro IPR015590 http://www.ebi.ac.uk/interpro/entry/IPR015590 InterPro IPR016160 http://www.ebi.ac.uk/interpro/entry/IPR016160 InterPro IPR016161 http://www.ebi.ac.uk/interpro/entry/IPR016161 InterPro IPR016162 http://www.ebi.ac.uk/interpro/entry/IPR016162 InterPro IPR016163 http://www.ebi.ac.uk/interpro/entry/IPR016163 InterPro IPR029510 http://www.ebi.ac.uk/interpro/entry/IPR029510 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2636 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2636 KEGG_Gene eco:b2661 http://www.genome.jp/dbget-bin/www_bget?eco:b2661 KEGG_Orthology KO:K00135 http://www.genome.jp/dbget-bin/www_bget?KO:K00135 KEGG_Pathway ko00250 http://www.genome.jp/kegg-bin/show_pathway?ko00250 KEGG_Pathway ko00350 http://www.genome.jp/kegg-bin/show_pathway?ko00350 KEGG_Pathway ko00650 http://www.genome.jp/kegg-bin/show_pathway?ko00650 KEGG_Reaction rn:R00713 http://www.genome.jp/dbget-bin/www_bget?rn:R00713 KEGG_Reaction rn:R00714 http://www.genome.jp/dbget-bin/www_bget?rn:R00714 OMA CENPGVR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CENPGVR PDB 3JZ4 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JZ4 PDBsum 3JZ4 http://www.ebi.ac.uk/pdbsum/3JZ4 PROSITE PS00070 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00070 PROSITE PS00687 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00687 PSORT swissprot:GABD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GABD_ECOLI PSORT-B swissprot:GABD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GABD_ECOLI PSORT2 swissprot:GABD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GABD_ECOLI Pfam PF00171 http://pfam.xfam.org/family/PF00171 Phobius swissprot:GABD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GABD_ECOLI PhylomeDB P25526 http://phylomedb.org/?seqid=P25526 ProteinModelPortal P25526 http://www.proteinmodelportal.org/query/uniprot/P25526 PubMed 14731280 http://www.ncbi.nlm.nih.gov/pubmed/14731280 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20174634 http://www.ncbi.nlm.nih.gov/pubmed/20174634 PubMed 7011797 http://www.ncbi.nlm.nih.gov/pubmed/7011797 PubMed 8297211 http://www.ncbi.nlm.nih.gov/pubmed/8297211 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417147 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417147 RefSeq WP_000772831 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000772831 SMR P25526 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P25526 STRING 511145.b2661 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2661&targetmode=cogs STRING COG1012 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1012&targetmode=cogs SUPFAM SSF53720 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53720 TIGRFAMs TIGR01780 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01780 UniProtKB GABD_ECOLI http://www.uniprot.org/uniprot/GABD_ECOLI UniProtKB-AC P25526 http://www.uniprot.org/uniprot/P25526 charge swissprot:GABD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GABD_ECOLI eggNOG COG1012 http://eggnogapi.embl.de/nog_data/html/tree/COG1012 eggNOG ENOG4105C26 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C26 epestfind swissprot:GABD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GABD_ECOLI garnier swissprot:GABD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GABD_ECOLI helixturnhelix swissprot:GABD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GABD_ECOLI hmoment swissprot:GABD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GABD_ECOLI iep swissprot:GABD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GABD_ECOLI inforesidue swissprot:GABD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GABD_ECOLI octanol swissprot:GABD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GABD_ECOLI pepcoil swissprot:GABD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GABD_ECOLI pepdigest swissprot:GABD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GABD_ECOLI pepinfo swissprot:GABD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GABD_ECOLI pepnet swissprot:GABD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GABD_ECOLI pepstats swissprot:GABD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GABD_ECOLI pepwheel swissprot:GABD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GABD_ECOLI pepwindow swissprot:GABD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GABD_ECOLI sigcleave swissprot:GABD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GABD_ECOLI ## Database ID URL or Descriptions # BioGrid 4259109 12 # CAUTION Was originally thought to be involved in multiple antibiotic resistance. {ECO:0000305|PubMed 8383113}. # EcoGene EG11637 marC # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoliWiki. # GOslim_component GO:0005575 cellular_component # InterPro IPR002771 Multi_antbiot-R_MarC # KEGG_Brite ko02000 Transporters # Organism MARC_ECOLI Escherichia coli (strain K12) # PATRIC 32118356 VBIEscCol129921_1598 # PIR D64907 D64907 # Pfam PF01914 MarC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MARC_ECOLI UPF0056 inner membrane protein MarC # RefSeq NP_416046 NC_000913.3 # RefSeq WP_000885033 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0056 (MarC) family. {ECO 0000305}. # SUBCELLULAR LOCATION MARC_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.95.1 the 6tms neutral amino acid transporter (naat) family # TIGRFAMs TIGR00427 TIGR00427 # eggNOG COG2095 LUCA # eggNOG ENOG41082NP Bacteria BLAST swissprot:MARC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MARC_ECOLI BioCyc ECOL316407:JW1522-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1522-MONOMER BioCyc EcoCyc:EG11637-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11637-MONOMER COG COG2095 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2095 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.052018199 http://dx.doi.org/10.1073/pnas.052018199 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AAC.00930-07 http://dx.doi.org/10.1128/AAC.00930-07 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M96235 http://www.ebi.ac.uk/ena/data/view/M96235 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1593 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1593 EcoGene EG11637 http://www.ecogene.org/geneInfo.php?eg_id=EG11637 EnsemblBacteria AAC74602 http://www.ensemblgenomes.org/id/AAC74602 EnsemblBacteria AAC74602 http://www.ensemblgenomes.org/id/AAC74602 EnsemblBacteria BAA15211 http://www.ensemblgenomes.org/id/BAA15211 EnsemblBacteria BAA15211 http://www.ensemblgenomes.org/id/BAA15211 EnsemblBacteria BAA15211 http://www.ensemblgenomes.org/id/BAA15211 EnsemblBacteria b1529 http://www.ensemblgenomes.org/id/b1529 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GeneID 947132 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947132 HOGENOM HOG000112971 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000112971&db=HOGENOM6 InParanoid P0AEY1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEY1 InterPro IPR002771 http://www.ebi.ac.uk/interpro/entry/IPR002771 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1522 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1522 KEGG_Gene eco:b1529 http://www.genome.jp/dbget-bin/www_bget?eco:b1529 KEGG_Orthology KO:K05595 http://www.genome.jp/dbget-bin/www_bget?KO:K05595 OMA LWISLRS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LWISLRS PSORT swissprot:MARC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MARC_ECOLI PSORT-B swissprot:MARC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MARC_ECOLI PSORT2 swissprot:MARC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MARC_ECOLI Pfam PF01914 http://pfam.xfam.org/family/PF01914 Phobius swissprot:MARC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MARC_ECOLI PhylomeDB P0AEY1 http://phylomedb.org/?seqid=P0AEY1 ProteinModelPortal P0AEY1 http://www.proteinmodelportal.org/query/uniprot/P0AEY1 PubMed 11867724 http://www.ncbi.nlm.nih.gov/pubmed/11867724 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17954692 http://www.ncbi.nlm.nih.gov/pubmed/17954692 PubMed 8383113 http://www.ncbi.nlm.nih.gov/pubmed/8383113 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416046 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416046 RefSeq WP_000885033 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000885033 STRING 511145.b1529 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1529&targetmode=cogs STRING COG2095 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2095&targetmode=cogs TCDB 2.A.95.1 http://www.tcdb.org/search/result.php?tc=2.A.95.1 TIGRFAMs TIGR00427 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00427 UniProtKB MARC_ECOLI http://www.uniprot.org/uniprot/MARC_ECOLI UniProtKB-AC P0AEY1 http://www.uniprot.org/uniprot/P0AEY1 charge swissprot:MARC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MARC_ECOLI eggNOG COG2095 http://eggnogapi.embl.de/nog_data/html/tree/COG2095 eggNOG ENOG41082NP http://eggnogapi.embl.de/nog_data/html/tree/ENOG41082NP epestfind swissprot:MARC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MARC_ECOLI garnier swissprot:MARC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MARC_ECOLI helixturnhelix swissprot:MARC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MARC_ECOLI hmoment swissprot:MARC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MARC_ECOLI iep swissprot:MARC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MARC_ECOLI inforesidue swissprot:MARC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MARC_ECOLI octanol swissprot:MARC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MARC_ECOLI pepcoil swissprot:MARC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MARC_ECOLI pepdigest swissprot:MARC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MARC_ECOLI pepinfo swissprot:MARC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MARC_ECOLI pepnet swissprot:MARC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MARC_ECOLI pepstats swissprot:MARC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MARC_ECOLI pepwheel swissprot:MARC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MARC_ECOLI pepwindow swissprot:MARC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MARC_ECOLI sigcleave swissprot:MARC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MARC_ECOLI ## Database ID URL or Descriptions # AltName Lipoate-protein ligase B {ECO:0000255|HAMAP-Rule MF_00013} # AltName Lipoyl/octanoyl transferase {ECO:0000255|HAMAP-Rule MF_00013} # AltName Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase {ECO:0000255|HAMAP-Rule MF_00013} # BIOPHYSICOCHEMICAL PROPERTIES LIPB_ECOLI Kinetic parameters KM=10.2 uM for octanoyl-ACP {ECO 0000269|PubMed 15642479}; KM=13.2 uM for apo-H protein {ECO 0000269|PubMed 15642479}; pH dependence Optimum pH is about 7.5. {ECO 0000269|PubMed 15642479}; # BioGrid 4261534 14 # CATALYTIC ACTIVITY Octanoyl-[acyl-carrier-protein] + protein = protein N(6)-(octanoyl)lysine + [acyl-carrier-protein]. {ECO:0000255|HAMAP-Rule MF_00013}. # EcoGene EG11591 lipB # FUNCTION LIPB_ECOLI Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. {ECO 0000255|HAMAP-Rule MF_00013, ECO 0000269|PubMed 15642479, ECO 0000269|PubMed 16342964}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003824 catalytic activity; IDA:EcoliWiki. # GO_function GO:0016415 octanoyltransferase activity; IMP:EcoCyc. # GO_function GO:0016740 transferase activity; IDA:EcoliWiki. # GO_function GO:0033819 lipoyl(octanoyl) transferase activity; IDA:EcoCyc. # GO_process GO:0006464 cellular protein modification process; IDA:EcoliWiki. # GO_process GO:0009106 lipoate metabolic process; IMP:EcoliWiki. # GO_process GO:0009107 lipoate biosynthetic process; IMP:EcoliWiki. # GO_process GO:0009249 protein lipoylation; IBA:GO_Central. # GO_process GO:0010629 negative regulation of gene expression; IMP:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # HAMAP MF_00013 LipB # InterPro IPR000544 Octanoyltransferase # InterPro IPR004143 BPL_LPL_catalytic # InterPro IPR020605 Octanoyltransferase_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00785 Lipoic acid metabolism # MASS SPECTROMETRY Mass=23880.45; Mass_error=1.31; Method=Electrospray; Range=1-213; Evidence={ECO:0000269|PubMed 15642479}; # MISCELLANEOUS LIPB_ECOLI In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon- amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes. # Organism LIPB_ECOLI Escherichia coli (strain K12) # PATHWAY Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier- protein]: step 1/2. {ECO 0000255|HAMAP-Rule:MF_00013}. # PATRIC 32116441 VBIEscCol129921_0660 # PIR D64797 D64797 # PIRSF PIRSF016262 LPLase # PROSITE PS01313 LIPB # PROSITE PS51733 BPL_LPL_CATALYTIC # Pfam PF03099 BPL_LplA_LipB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Octanoyltransferase {ECO:0000255|HAMAP-Rule MF_00013} # RefSeq NP_415163 NC_000913.3 # RefSeq WP_000284027 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA66342.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAB40830.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the LipB family. {ECO:0000255|HAMAP- Rule MF_00013}. # SIMILARITY Contains 1 BPL/LPL catalytic domain. {ECO:0000255|PROSITE-ProRule PRU01067}. # SUBCELLULAR LOCATION LIPB_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00013}. # SUBUNIT Monomer or homotrimer. Both forms are active. {ECO:0000269|PubMed 15642479}. # TIGRFAMs TIGR00214 lipB # UniPathway UPA00538 UER00592 # eggNOG COG0321 LUCA # eggNOG ENOG4108BDP Bacteria BLAST swissprot:LIPB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LIPB_ECOLI BioCyc ECOL316407:JW5089-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5089-MONOMER BioCyc EcoCyc:EG11591-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11591-MONOMER BioCyc MetaCyc:EG11591-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11591-MONOMER COG COG0321 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0321 DOI 10.1002/path.1711770102 http://dx.doi.org/10.1002/path.1711770102 DOI 10.1016/j.pep.2004.10.021 http://dx.doi.org/10.1016/j.pep.2004.10.021 DOI 10.1021/bi051865y http://dx.doi.org/10.1021/bi051865y DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.185.5.1582-1589.2003 http://dx.doi.org/10.1128/JB.185.5.1582-1589.2003 EC_number EC:2.3.1.181 {ECO:0000255|HAMAP-Rule:MF_00013} http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.181 {ECO:0000255|HAMAP-Rule:MF_00013} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L07636 http://www.ebi.ac.uk/ena/data/view/L07636 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 ENZYME 2.3.1.181 {ECO:0000255|HAMAP-Rule:MF_00013} http://enzyme.expasy.org/EC/2.3.1.181 {ECO:0000255|HAMAP-Rule:MF_00013} EchoBASE EB1283 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1283 EcoGene EG11591 http://www.ecogene.org/geneInfo.php?eg_id=EG11591 EnsemblBacteria AAC73731 http://www.ensemblgenomes.org/id/AAC73731 EnsemblBacteria AAC73731 http://www.ensemblgenomes.org/id/AAC73731 EnsemblBacteria BAA35273 http://www.ensemblgenomes.org/id/BAA35273 EnsemblBacteria BAA35273 http://www.ensemblgenomes.org/id/BAA35273 EnsemblBacteria BAA35273 http://www.ensemblgenomes.org/id/BAA35273 EnsemblBacteria b0630 http://www.ensemblgenomes.org/id/b0630 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003824 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003824 GO_function GO:0016415 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016415 GO_function GO:0016740 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016740 GO_function GO:0033819 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033819 GO_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GO_process GO:0009106 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009106 GO_process GO:0009107 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009107 GO_process GO:0009249 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009249 GO_process GO:0010629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010629 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GeneID 945217 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945217 HAMAP MF_00013 http://hamap.expasy.org/unirule/MF_00013 HOGENOM HOG000194321 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000194321&db=HOGENOM6 InParanoid P60720 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P60720 IntEnz 2.3.1.181 {ECO:0000255|HAMAP-Rule:MF_00013} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.181 {ECO:0000255|HAMAP-Rule:MF_00013} InterPro IPR000544 http://www.ebi.ac.uk/interpro/entry/IPR000544 InterPro IPR004143 http://www.ebi.ac.uk/interpro/entry/IPR004143 InterPro IPR020605 http://www.ebi.ac.uk/interpro/entry/IPR020605 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5089 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5089 KEGG_Gene eco:b0630 http://www.genome.jp/dbget-bin/www_bget?eco:b0630 KEGG_Orthology KO:K03801 http://www.genome.jp/dbget-bin/www_bget?KO:K03801 KEGG_Pathway ko00785 http://www.genome.jp/kegg-bin/show_pathway?ko00785 KEGG_Reaction rn:R07766 http://www.genome.jp/dbget-bin/www_bget?rn:R07766 KEGG_Reaction rn:R07769 http://www.genome.jp/dbget-bin/www_bget?rn:R07769 OMA DEKKVCS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DEKKVCS PROSITE PS01313 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01313 PROSITE PS51733 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51733 PSORT swissprot:LIPB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LIPB_ECOLI PSORT-B swissprot:LIPB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LIPB_ECOLI PSORT2 swissprot:LIPB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LIPB_ECOLI Pfam PF03099 http://pfam.xfam.org/family/PF03099 Phobius swissprot:LIPB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LIPB_ECOLI PhylomeDB P60720 http://phylomedb.org/?seqid=P60720 ProteinModelPortal P60720 http://www.proteinmodelportal.org/query/uniprot/P60720 PubMed 12591875 http://www.ncbi.nlm.nih.gov/pubmed/12591875 PubMed 15642479 http://www.ncbi.nlm.nih.gov/pubmed/15642479 PubMed 16342964 http://www.ncbi.nlm.nih.gov/pubmed/16342964 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8002607 http://www.ncbi.nlm.nih.gov/pubmed/8002607 PubMed 8444795 http://www.ncbi.nlm.nih.gov/pubmed/8444795 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415163 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415163 RefSeq WP_000284027 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000284027 STRING 511145.b0630 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0630&targetmode=cogs STRING COG0321 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0321&targetmode=cogs TIGRFAMs TIGR00214 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00214 UniProtKB LIPB_ECOLI http://www.uniprot.org/uniprot/LIPB_ECOLI UniProtKB-AC P60720 http://www.uniprot.org/uniprot/P60720 charge swissprot:LIPB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LIPB_ECOLI eggNOG COG0321 http://eggnogapi.embl.de/nog_data/html/tree/COG0321 eggNOG ENOG4108BDP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108BDP epestfind swissprot:LIPB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LIPB_ECOLI garnier swissprot:LIPB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LIPB_ECOLI helixturnhelix swissprot:LIPB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LIPB_ECOLI hmoment swissprot:LIPB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LIPB_ECOLI iep swissprot:LIPB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LIPB_ECOLI inforesidue swissprot:LIPB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LIPB_ECOLI octanol swissprot:LIPB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LIPB_ECOLI pepcoil swissprot:LIPB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LIPB_ECOLI pepdigest swissprot:LIPB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LIPB_ECOLI pepinfo swissprot:LIPB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LIPB_ECOLI pepnet swissprot:LIPB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LIPB_ECOLI pepstats swissprot:LIPB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LIPB_ECOLI pepwheel swissprot:LIPB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LIPB_ECOLI pepwindow swissprot:LIPB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LIPB_ECOLI sigcleave swissprot:LIPB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LIPB_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES TADA_ECOLI Kinetic parameters KM=0.83 uM for tRNA(Arg2) {ECO 0000269|PubMed 16700551}; Note=kcat is 13 min(-1). {ECO 0000269|PubMed 16700551}; # BRENDA 3.5.4.33 2026 # BioGrid 4261245 24 # CATALYTIC ACTIVITY TADA_ECOLI Adenine(34) in tRNA + H(2)O = hypoxanthine(34) in tRNA + NH(3). {ECO 0000255|HAMAP-Rule MF_00972, ECO 0000269|PubMed 12110595, ECO 0000269|PubMed 16700551}. # COFACTOR TADA_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000255|HAMAP-Rule MF_00972, ECO 0000269|PubMed 16700551}; Note=Binds 1 zinc ion per subunit. {ECO 0000255|HAMAP- Rule MF_00972, ECO 0000269|PubMed 16700551}; # DISRUPTION PHENOTYPE Mutation makes E.coli resistant to the toxic proteins encoded by the gef gene family. {ECO:0000269|PubMed 1602968}. # EcoGene EG11372 tadA # FUNCTION TADA_ECOLI Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2). Essential for cell viability. {ECO 0000255|HAMAP-Rule MF_00972, ECO 0000269|PubMed 12110595, ECO 0000269|PubMed 16700551}. # GO_function GO:0008251 tRNA-specific adenosine deaminase activity; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0052717 tRNA-specific adenosine-34 deaminase activity; IEA:UniProtKB-HAMAP. # GO_process GO:0002100 tRNA wobble adenosine to inosine editing; IDA:EcoCyc. # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # HAMAP MF_00972 tRNA_aden_deaminase # IntAct P68398 4 # InterPro IPR002125 CMP_dCMP_Zn-bd # InterPro IPR016192 APOBEC/CMP_deaminase_Zn-bd # InterPro IPR016193 Cytidine_deaminase-like # InterPro IPR028883 tRNA_aden_deaminase # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # Organism TADA_ECOLI Escherichia coli (strain K12) # PATRIC 32120517 VBIEscCol129921_2661 # PDB 1Z3A X-ray; 2.03 A; A/B=2-167 # PIR F65033 F65033 # PROSITE PS00903 CYT_DCMP_DEAMINASES_1 # PROSITE PS51747 CYT_DCMP_DEAMINASES_2 # Pfam PF14437 MafB19-deam # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName tRNA-specific adenosine deaminase {ECO:0000255|HAMAP-Rule MF_00972} # RefSeq NP_417054 NC_000913.3 # RefSeq WP_001297409 NZ_LN832404.1 # SEQUENCE CAUTION TADA_ECOLI Sequence=AAA79821.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=BAA10909.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=BAE76735.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=CAA51064.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the cytidine and deoxycytidylate deaminase family. {ECO:0000255|HAMAP-Rule MF_00972}. # SIMILARITY Contains 1 CMP/dCMP-type deaminase domain. {ECO:0000255|PROSITE-ProRule PRU01083}. # SUBUNIT TADA_ECOLI Homodimer. {ECO 0000255|HAMAP-Rule MF_00972, ECO 0000269|PubMed 12110595, ECO 0000269|PubMed 16700551}. # SUPFAM SSF53927 SSF53927 # eggNOG COG0590 LUCA # eggNOG ENOG4108Z6B Bacteria BLAST swissprot:TADA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TADA_ECOLI BioCyc ECOL316407:JW2543-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2543-MONOMER BioCyc EcoCyc:EG11372-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11372-MONOMER BioCyc MetaCyc:EG11372-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11372-MONOMER COG COG0590 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0590 DOI 10.1021/bi0522394 http://dx.doi.org/10.1021/bi0522394 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/emboj/cdf362 http://dx.doi.org/10.1093/emboj/cdf362 DOI 10.1111/j.1365-2958.1992.tb01540.x http://dx.doi.org/10.1111/j.1365-2958.1992.tb01540.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.5.4.33 {ECO:0000255|HAMAP-Rule:MF_00972} http://www.genome.jp/dbget-bin/www_bget?EC:3.5.4.33 {ECO:0000255|HAMAP-Rule:MF_00972} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D64044 http://www.ebi.ac.uk/ena/data/view/D64044 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36841 http://www.ebi.ac.uk/ena/data/view/U36841 EMBL X72336 http://www.ebi.ac.uk/ena/data/view/X72336 ENZYME 3.5.4.33 {ECO:0000255|HAMAP-Rule:MF_00972} http://enzyme.expasy.org/EC/3.5.4.33 {ECO:0000255|HAMAP-Rule:MF_00972} EchoBASE EB1346 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1346 EcoGene EG11372 http://www.ecogene.org/geneInfo.php?eg_id=EG11372 EnsemblBacteria AAC75612 http://www.ensemblgenomes.org/id/AAC75612 EnsemblBacteria AAC75612 http://www.ensemblgenomes.org/id/AAC75612 EnsemblBacteria BAE76735 http://www.ensemblgenomes.org/id/BAE76735 EnsemblBacteria BAE76735 http://www.ensemblgenomes.org/id/BAE76735 EnsemblBacteria BAE76735 http://www.ensemblgenomes.org/id/BAE76735 EnsemblBacteria b2559 http://www.ensemblgenomes.org/id/b2559 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008251 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008251 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0052717 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052717 GO_process GO:0002100 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002100 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GeneID 947027 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947027 HAMAP MF_00972 http://hamap.expasy.org/unirule/MF_00972 HOGENOM HOG000085050 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000085050&db=HOGENOM6 InParanoid P68398 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P68398 IntAct P68398 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P68398* IntEnz 3.5.4.33 {ECO:0000255|HAMAP-Rule:MF_00972} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.4.33 {ECO:0000255|HAMAP-Rule:MF_00972} InterPro IPR002125 http://www.ebi.ac.uk/interpro/entry/IPR002125 InterPro IPR016192 http://www.ebi.ac.uk/interpro/entry/IPR016192 InterPro IPR016193 http://www.ebi.ac.uk/interpro/entry/IPR016193 InterPro IPR028883 http://www.ebi.ac.uk/interpro/entry/IPR028883 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW2543 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2543 KEGG_Gene eco:b2559 http://www.genome.jp/dbget-bin/www_bget?eco:b2559 KEGG_Orthology KO:K11991 http://www.genome.jp/dbget-bin/www_bget?KO:K11991 OMA RIGRIFF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RIGRIFF PDB 1Z3A http://www.ebi.ac.uk/pdbe-srv/view/entry/1Z3A PDBsum 1Z3A http://www.ebi.ac.uk/pdbsum/1Z3A PROSITE PS00903 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00903 PROSITE PS51747 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51747 PSORT swissprot:TADA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TADA_ECOLI PSORT-B swissprot:TADA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TADA_ECOLI PSORT2 swissprot:TADA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TADA_ECOLI Pfam PF14437 http://pfam.xfam.org/family/PF14437 Phobius swissprot:TADA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TADA_ECOLI PhylomeDB P68398 http://phylomedb.org/?seqid=P68398 ProteinModelPortal P68398 http://www.proteinmodelportal.org/query/uniprot/P68398 PubMed 12110595 http://www.ncbi.nlm.nih.gov/pubmed/12110595 PubMed 1602968 http://www.ncbi.nlm.nih.gov/pubmed/1602968 PubMed 16700551 http://www.ncbi.nlm.nih.gov/pubmed/16700551 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417054 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417054 RefSeq WP_001297409 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001297409 SMR P68398 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P68398 STRING 511145.b2559 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2559&targetmode=cogs STRING COG0590 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0590&targetmode=cogs SUPFAM SSF53927 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53927 UniProtKB TADA_ECOLI http://www.uniprot.org/uniprot/TADA_ECOLI UniProtKB-AC P68398 http://www.uniprot.org/uniprot/P68398 charge swissprot:TADA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TADA_ECOLI eggNOG COG0590 http://eggnogapi.embl.de/nog_data/html/tree/COG0590 eggNOG ENOG4108Z6B http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Z6B epestfind swissprot:TADA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TADA_ECOLI garnier swissprot:TADA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TADA_ECOLI helixturnhelix swissprot:TADA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TADA_ECOLI hmoment swissprot:TADA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TADA_ECOLI iep swissprot:TADA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TADA_ECOLI inforesidue swissprot:TADA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TADA_ECOLI octanol swissprot:TADA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TADA_ECOLI pepcoil swissprot:TADA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TADA_ECOLI pepdigest swissprot:TADA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TADA_ECOLI pepinfo swissprot:TADA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TADA_ECOLI pepnet swissprot:TADA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TADA_ECOLI pepstats swissprot:TADA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TADA_ECOLI pepwheel swissprot:TADA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TADA_ECOLI pepwindow swissprot:TADA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TADA_ECOLI sigcleave swissprot:TADA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TADA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259908 201 # CATALYTIC ACTIVITY HOLA_ECOLI Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). # EcoGene EG11412 holA # FUNCTION HOLA_ECOLI DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA. # GO_component GO:0009360 DNA polymerase III complex; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_function GO:0003887 DNA-directed DNA polymerase activity; IEA:UniProtKB-KW. # GO_process GO:0006261 DNA-dependent DNA replication; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.300 -; 1. # INTERACTION HOLA_ECOLI P10443 dnaE; NbExp=4; IntAct=EBI-549153, EBI-549111; P0A988 dnaN; NbExp=10; IntAct=EBI-549153, EBI-542385; P06710-1 dnaX; NbExp=5; IntAct=EBI-549153, EBI-6464728; P06710-2 dnaX; NbExp=6; IntAct=EBI-549153, EBI-2604194; P28631 holB; NbExp=17; IntAct=EBI-549153, EBI-549161; P23367 mutL; NbExp=2; IntAct=EBI-549153, EBI-554913; P17117 nfsA; NbExp=3; IntAct=EBI-549153, EBI-1120624; P64526 yeeW; NbExp=2; IntAct=EBI-549153, EBI-9146863; # IntAct P28630 49 # InterPro IPR005790 DNA_polIII_delta # InterPro IPR008921 DNA_pol3_clamp-load_cplx_C # InterPro IPR010372 DNA_pol3_delta_N # InterPro IPR027417 P-loop_NTPase # InterPro IPR032780 DNA_pol3_delt_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03032 DNA replication proteins # KEGG_Brite ko03032 M00260 DNA polymerase III complex, bacteria # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Brite ko03400 M00260 DNA polymerase III complex, bacteria # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00240 Pyrimidine metabolism # KEGG_Pathway ko03030 DNA replication # KEGG_Pathway ko03430 Mismatch repair # KEGG_Pathway ko03440 Homologous recombination # Organism HOLA_ECOLI Escherichia coli (strain K12) # PATRIC 32116463 VBIEscCol129921_0671 # PDB 1JQJ X-ray; 2.90 A; C/D=1-343 # PDB 1JQL X-ray; 2.50 A; B=1-140 # PDB 1JR3 X-ray; 2.70 A; D=1-343 # PDB 1XXH X-ray; 3.45 A; A/F=1-343 # PDB 1XXI X-ray; 4.10 A; A/F=1-343 # PDB 3GLF X-ray; 3.39 A; A/F=1-343 # PDB 3GLG X-ray; 3.25 A; A/F=1-343 # PDB 3GLH X-ray; 3.89 A; A/F/K=1-343 # PDB 3GLI X-ray; 3.50 A; A/F=1-343 # PIR A45251 A45251 # Pfam PF06144 DNA_pol3_delta # Pfam PF14840 DNA_pol3_delt_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HOLA_ECOLI DNA polymerase III subunit delta # RefSeq NP_415173 NC_000913.3 # RefSeq WP_000620535 NZ_LN832404.1 # SUBUNIT The DNA polymerase holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential subassemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core (subunits alpha,epsilon and theta) contains the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork. This complex contains delta, delta', psi and chi, and copies of either or both of two different DnaX proteins, gamma and tau. The composition of the holoenzyme is, therefore (alpha,epsilon,theta)[2]-(gamma/tau)[3]-delta,delta', psi,chi- beta[4]. # SUPFAM SSF48019 SSF48019 # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR01128 holA # eggNOG COG1466 LUCA # eggNOG ENOG4105DJF Bacteria BLAST swissprot:HOLA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HOLA_ECOLI BioCyc ECOL316407:JW0635-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0635-MONOMER BioCyc EcoCyc:EG11412-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11412-MONOMER BioCyc MetaCyc:EG11412-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11412-MONOMER COG COG1466 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1466 DIP DIP-9931N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9931N DOI 10.1002/bies.950140206 http://dx.doi.org/10.1002/bies.950140206 DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.7.7 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.7 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L04576 http://www.ebi.ac.uk/ena/data/view/L04576 EMBL M18277 http://www.ebi.ac.uk/ena/data/view/M18277 EMBL M94267 http://www.ebi.ac.uk/ena/data/view/M94267 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 ENZYME 2.7.7.7 http://enzyme.expasy.org/EC/2.7.7.7 EchoBASE EB1384 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1384 EcoGene EG11412 http://www.ecogene.org/geneInfo.php?eg_id=EG11412 EnsemblBacteria AAC73741 http://www.ensemblgenomes.org/id/AAC73741 EnsemblBacteria AAC73741 http://www.ensemblgenomes.org/id/AAC73741 EnsemblBacteria BAA35287 http://www.ensemblgenomes.org/id/BAA35287 EnsemblBacteria BAA35287 http://www.ensemblgenomes.org/id/BAA35287 EnsemblBacteria BAA35287 http://www.ensemblgenomes.org/id/BAA35287 EnsemblBacteria b0640 http://www.ensemblgenomes.org/id/b0640 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009360 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003887 GO_process GO:0006261 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006261 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947573 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947573 HOGENOM HOG000256204 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000256204&db=HOGENOM6 InParanoid P28630 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P28630 IntAct P28630 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P28630* IntEnz 2.7.7.7 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.7 InterPro IPR005790 http://www.ebi.ac.uk/interpro/entry/IPR005790 InterPro IPR008921 http://www.ebi.ac.uk/interpro/entry/IPR008921 InterPro IPR010372 http://www.ebi.ac.uk/interpro/entry/IPR010372 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR032780 http://www.ebi.ac.uk/interpro/entry/IPR032780 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03032 http://www.genome.jp/dbget-bin/www_bget?ko03032 KEGG_Brite ko03032 http://www.genome.jp/dbget-bin/www_bget?ko03032 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW0635 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0635 KEGG_Gene eco:b0640 http://www.genome.jp/dbget-bin/www_bget?eco:b0640 KEGG_Orthology KO:K02340 http://www.genome.jp/dbget-bin/www_bget?KO:K02340 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Pathway ko03030 http://www.genome.jp/kegg-bin/show_pathway?ko03030 KEGG_Pathway ko03430 http://www.genome.jp/kegg-bin/show_pathway?ko03430 KEGG_Pathway ko03440 http://www.genome.jp/kegg-bin/show_pathway?ko03440 KEGG_Reaction rn:R00375 http://www.genome.jp/dbget-bin/www_bget?rn:R00375 KEGG_Reaction rn:R00376 http://www.genome.jp/dbget-bin/www_bget?rn:R00376 KEGG_Reaction rn:R00377 http://www.genome.jp/dbget-bin/www_bget?rn:R00377 KEGG_Reaction rn:R00378 http://www.genome.jp/dbget-bin/www_bget?rn:R00378 MINT MINT-1235044 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1235044 OMA RQQGFDE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RQQGFDE PDB 1JQJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1JQJ PDB 1JQL http://www.ebi.ac.uk/pdbe-srv/view/entry/1JQL PDB 1JR3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1JR3 PDB 1XXH http://www.ebi.ac.uk/pdbe-srv/view/entry/1XXH PDB 1XXI http://www.ebi.ac.uk/pdbe-srv/view/entry/1XXI PDB 3GLF http://www.ebi.ac.uk/pdbe-srv/view/entry/3GLF PDB 3GLG http://www.ebi.ac.uk/pdbe-srv/view/entry/3GLG PDB 3GLH http://www.ebi.ac.uk/pdbe-srv/view/entry/3GLH PDB 3GLI http://www.ebi.ac.uk/pdbe-srv/view/entry/3GLI PDBsum 1JQJ http://www.ebi.ac.uk/pdbsum/1JQJ PDBsum 1JQL http://www.ebi.ac.uk/pdbsum/1JQL PDBsum 1JR3 http://www.ebi.ac.uk/pdbsum/1JR3 PDBsum 1XXH http://www.ebi.ac.uk/pdbsum/1XXH PDBsum 1XXI http://www.ebi.ac.uk/pdbsum/1XXI PDBsum 3GLF http://www.ebi.ac.uk/pdbsum/3GLF PDBsum 3GLG http://www.ebi.ac.uk/pdbsum/3GLG PDBsum 3GLH http://www.ebi.ac.uk/pdbsum/3GLH PDBsum 3GLI http://www.ebi.ac.uk/pdbsum/3GLI PSORT swissprot:HOLA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HOLA_ECOLI PSORT-B swissprot:HOLA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HOLA_ECOLI PSORT2 swissprot:HOLA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HOLA_ECOLI Pfam PF06144 http://pfam.xfam.org/family/PF06144 Pfam PF14840 http://pfam.xfam.org/family/PF14840 Phobius swissprot:HOLA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HOLA_ECOLI PhylomeDB P28630 http://phylomedb.org/?seqid=P28630 ProteinModelPortal P28630 http://www.proteinmodelportal.org/query/uniprot/P28630 PubMed 1400251 http://www.ncbi.nlm.nih.gov/pubmed/1400251 PubMed 1575709 http://www.ncbi.nlm.nih.gov/pubmed/1575709 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3316191 http://www.ncbi.nlm.nih.gov/pubmed/3316191 PubMed 8505303 http://www.ncbi.nlm.nih.gov/pubmed/8505303 PubMed 8505304 http://www.ncbi.nlm.nih.gov/pubmed/8505304 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_415173 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415173 RefSeq WP_000620535 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000620535 SMR P28630 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P28630 STRING 511145.b0640 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0640&targetmode=cogs STRING COG1466 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1466&targetmode=cogs SUPFAM SSF48019 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48019 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR01128 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01128 UniProtKB HOLA_ECOLI http://www.uniprot.org/uniprot/HOLA_ECOLI UniProtKB-AC P28630 http://www.uniprot.org/uniprot/P28630 charge swissprot:HOLA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HOLA_ECOLI eggNOG COG1466 http://eggnogapi.embl.de/nog_data/html/tree/COG1466 eggNOG ENOG4105DJF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DJF epestfind swissprot:HOLA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HOLA_ECOLI garnier swissprot:HOLA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HOLA_ECOLI helixturnhelix swissprot:HOLA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HOLA_ECOLI hmoment swissprot:HOLA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HOLA_ECOLI iep swissprot:HOLA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HOLA_ECOLI inforesidue swissprot:HOLA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HOLA_ECOLI octanol swissprot:HOLA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HOLA_ECOLI pepcoil swissprot:HOLA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HOLA_ECOLI pepdigest swissprot:HOLA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HOLA_ECOLI pepinfo swissprot:HOLA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HOLA_ECOLI pepnet swissprot:HOLA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HOLA_ECOLI pepstats swissprot:HOLA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HOLA_ECOLI pepwheel swissprot:HOLA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HOLA_ECOLI pepwindow swissprot:HOLA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HOLA_ECOLI sigcleave swissprot:HOLA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HOLA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262294 8 # EcoGene EG13033 ygcE # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0016301 kinase activity; IEA:UniProtKB-KW. # GO_function GO:0016773 phosphotransferase activity, alcohol group as acceptor; IBA:GO_Central. # GO_process GO:0005975 carbohydrate metabolic process; IEA:InterPro. # GO_process GO:0016310 phosphorylation; IBA:GO_Central. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016301 kinase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0008150 biological_process # InterPro IPR018484 Carb_kinase_FGGY_N # InterPro IPR018485 Carb_kinase_FGGY_C # Organism YGCE_ECOLI Escherichia coli (strain K12) # PATRIC 32120962 VBIEscCol129921_2873 # PIR D65059 D65059 # Pfam PF00370 FGGY_N; 2 # Pfam PF02782 FGGY_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGCE_ECOLI Uncharacterized sugar kinase YgcE # RefSeq NP_417256 NC_000913.3 # RefSeq WP_000039688 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA69286.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the FGGY kinase family. {ECO 0000305}. # eggNOG COG1070 LUCA # eggNOG ENOG4108CWB Bacteria BLAST swissprot:YGCE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGCE_ECOLI BioCyc ECOL316407:JW5444-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5444-MONOMER BioCyc EcoCyc:G7442-MONOMER http://biocyc.org/getid?id=EcoCyc:G7442-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29580 http://www.ebi.ac.uk/ena/data/view/U29580 ENZYME 2.7.1.- http://enzyme.expasy.org/EC/2.7.1.- EchoBASE EB2848 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2848 EcoGene EG13033 http://www.ecogene.org/geneInfo.php?eg_id=EG13033 EnsemblBacteria AAC75818 http://www.ensemblgenomes.org/id/AAC75818 EnsemblBacteria AAC75818 http://www.ensemblgenomes.org/id/AAC75818 EnsemblBacteria BAE76850 http://www.ensemblgenomes.org/id/BAE76850 EnsemblBacteria BAE76850 http://www.ensemblgenomes.org/id/BAE76850 EnsemblBacteria BAE76850 http://www.ensemblgenomes.org/id/BAE76850 EnsemblBacteria b2776 http://www.ensemblgenomes.org/id/b2776 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_function GO:0016773 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016773 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GO_process GO:0016310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016310 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 946193 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946193 HOGENOM HOG000124135 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000124135&db=HOGENOM6 InParanoid P55138 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P55138 IntEnz 2.7.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1 InterPro IPR018484 http://www.ebi.ac.uk/interpro/entry/IPR018484 InterPro IPR018485 http://www.ebi.ac.uk/interpro/entry/IPR018485 KEGG_Gene ecj:JW5444 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5444 KEGG_Gene eco:b2776 http://www.genome.jp/dbget-bin/www_bget?eco:b2776 OMA SWAWSEN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SWAWSEN PSORT swissprot:YGCE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGCE_ECOLI PSORT-B swissprot:YGCE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGCE_ECOLI PSORT2 swissprot:YGCE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGCE_ECOLI Pfam PF00370 http://pfam.xfam.org/family/PF00370 Pfam PF02782 http://pfam.xfam.org/family/PF02782 Phobius swissprot:YGCE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGCE_ECOLI PhylomeDB P55138 http://phylomedb.org/?seqid=P55138 ProteinModelPortal P55138 http://www.proteinmodelportal.org/query/uniprot/P55138 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417256 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417256 RefSeq WP_000039688 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000039688 STRING 511145.b2776 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2776&targetmode=cogs UniProtKB YGCE_ECOLI http://www.uniprot.org/uniprot/YGCE_ECOLI UniProtKB-AC P55138 http://www.uniprot.org/uniprot/P55138 charge swissprot:YGCE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGCE_ECOLI eggNOG COG1070 http://eggnogapi.embl.de/nog_data/html/tree/COG1070 eggNOG ENOG4108CWB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108CWB epestfind swissprot:YGCE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGCE_ECOLI garnier swissprot:YGCE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGCE_ECOLI helixturnhelix swissprot:YGCE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGCE_ECOLI hmoment swissprot:YGCE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGCE_ECOLI iep swissprot:YGCE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGCE_ECOLI inforesidue swissprot:YGCE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGCE_ECOLI octanol swissprot:YGCE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGCE_ECOLI pepcoil swissprot:YGCE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGCE_ECOLI pepdigest swissprot:YGCE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGCE_ECOLI pepinfo swissprot:YGCE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGCE_ECOLI pepnet swissprot:YGCE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGCE_ECOLI pepstats swissprot:YGCE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGCE_ECOLI pepwheel swissprot:YGCE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGCE_ECOLI pepwindow swissprot:YGCE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGCE_ECOLI sigcleave swissprot:YGCE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGCE_ECOLI ## Database ID URL or Descriptions # AltName FIC_ECOLI Cell filamentation protein fic # BioGrid 4261083 52 # CATALYTIC ACTIVITY FIC_ECOLI ATP + [protein] = diphosphate + [protein]-AMP. # EcoGene EG10307 fic # FUNCTION FIC_ECOLI Probable adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (By similarity). Involved in cell filamentation induced by cyclic AMP. May have some role in cell division. {ECO 0000250}. # GO_function FIC_ECOLI GO 0043338 CTP 2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity; IEA UniProtKB-EC. # GO_function FIC_ECOLI GO 0043910 ATP coenzyme F420 adenylyltransferase activity; IEA UniProtKB-EC. # GO_function GO:0003720 telomerase activity; IEA:UniProtKB-EC. # GO_function GO:0003724 RNA helicase activity; IEA:UniProtKB-EC. # GO_function GO:0003896 DNA primase activity; IEA:UniProtKB-EC. # GO_function GO:0004779 sulfate adenylyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0008193 tRNA guanylyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0008905 mannose-phosphate guanylyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0033677 DNA/RNA helicase activity; IEA:UniProtKB-EC. # GO_function GO:0043814 phospholactate guanylyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0052630 UDP-N-acetylgalactosamine diphosphorylase activity; IEA:UniProtKB-EC. # GO_process GO:0051302 regulation of cell division; IMP:EcoCyc. # GOslim_function GO:0004386 helicase activity # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # Gene3D 1.10.3290.10 -; 1. # INTERACTION FIC_ECOLI P06710 dnaX; NbExp=2; IntAct=EBI-1132602, EBI-549140; # IntAct P20605 5 # InterPro IPR003812 Fido # KEGG_Brite ko03036 Chromosome # Organism FIC_ECOLI Escherichia coli (strain K12) # PATRIC 32122156 VBIEscCol129921_3455 # PDB 5JFF X-ray; 2.00 A; A/C=1-200 # PDB 5JFZ X-ray; 2.40 A; A/C/E=3-200 # PIR D65130 D65130 # PROSITE PS51459 FIDO # Pfam PF02661 Fic # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FIC_ECOLI Probable adenosine monophosphate-protein transferase fic # RefSeq NP_417820 NC_000913.3 # RefSeq WP_001280641 NZ_LN832404.1 # SIMILARITY Belongs to the fic family. {ECO 0000305}. # SIMILARITY Contains 1 fido domain. {ECO:0000255|PROSITE- ProRule PRU00791}. # SUPFAM SSF140931 SSF140931 # eggNOG COG2184 LUCA # eggNOG ENOG4105MZU Bacteria BLAST swissprot:FIC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FIC_ECOLI BioCyc ECOL316407:JW3324-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3324-MONOMER BioCyc EcoCyc:EG10307-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10307-MONOMER COG COG2184 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2184 DIP DIP-9608N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9608N DOI 10.1021/bi00226a009 http://dx.doi.org/10.1021/bi00226a009 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1271/bbb.59.1573 http://dx.doi.org/10.1271/bbb.59.1573 EC_number EC:2.7.7.n1 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.n1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M28363 http://www.ebi.ac.uk/ena/data/view/M28363 EMBL M32354 http://www.ebi.ac.uk/ena/data/view/M32354 EMBL M55429 http://www.ebi.ac.uk/ena/data/view/M55429 EMBL S79599 http://www.ebi.ac.uk/ena/data/view/S79599 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 2.7.7.n1 http://enzyme.expasy.org/EC/2.7.7.n1 EchoBASE EB0303 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0303 EcoGene EG10307 http://www.ecogene.org/geneInfo.php?eg_id=EG10307 EnsemblBacteria AAC76386 http://www.ensemblgenomes.org/id/AAC76386 EnsemblBacteria AAC76386 http://www.ensemblgenomes.org/id/AAC76386 EnsemblBacteria BAE77929 http://www.ensemblgenomes.org/id/BAE77929 EnsemblBacteria BAE77929 http://www.ensemblgenomes.org/id/BAE77929 EnsemblBacteria BAE77929 http://www.ensemblgenomes.org/id/BAE77929 EnsemblBacteria b3361 http://www.ensemblgenomes.org/id/b3361 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003720 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003720 GO_function GO:0003724 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003724 GO_function GO:0003896 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003896 GO_function GO:0004779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004779 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008193 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008193 GO_function GO:0008905 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008905 GO_function GO:0033677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033677 GO_function GO:0043338 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043338 GO_function GO:0043814 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043814 GO_function GO:0043910 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043910 GO_function GO:0052630 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052630 GO_process GO:0051302 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051302 GOslim_function GO:0004386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004386 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.10.3290.10 http://www.cathdb.info/version/latest/superfamily/1.10.3290.10 GeneID 947872 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947872 HOGENOM HOG000125441 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125441&db=HOGENOM6 InParanoid P20605 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P20605 IntAct P20605 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P20605* IntEnz 2.7.7.n1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.n1 InterPro IPR003812 http://www.ebi.ac.uk/interpro/entry/IPR003812 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene ecj:JW3324 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3324 KEGG_Gene eco:b3361 http://www.genome.jp/dbget-bin/www_bget?eco:b3361 KEGG_Orthology KO:K04095 http://www.genome.jp/dbget-bin/www_bget?KO:K04095 OMA VLHPFRI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VLHPFRI PDB 5JFF http://www.ebi.ac.uk/pdbe-srv/view/entry/5JFF PDB 5JFZ http://www.ebi.ac.uk/pdbe-srv/view/entry/5JFZ PDBsum 5JFF http://www.ebi.ac.uk/pdbsum/5JFF PDBsum 5JFZ http://www.ebi.ac.uk/pdbsum/5JFZ PROSITE PS51459 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51459 PSORT swissprot:FIC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FIC_ECOLI PSORT-B swissprot:FIC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FIC_ECOLI PSORT2 swissprot:FIC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FIC_ECOLI Pfam PF02661 http://pfam.xfam.org/family/PF02661 Phobius swissprot:FIC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FIC_ECOLI PhylomeDB P20605 http://phylomedb.org/?seqid=P20605 ProteinModelPortal P20605 http://www.proteinmodelportal.org/query/uniprot/P20605 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2007139 http://www.ncbi.nlm.nih.gov/pubmed/2007139 PubMed 2403545 http://www.ncbi.nlm.nih.gov/pubmed/2403545 PubMed 2546924 http://www.ncbi.nlm.nih.gov/pubmed/2546924 PubMed 7549107 http://www.ncbi.nlm.nih.gov/pubmed/7549107 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417820 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417820 RefSeq WP_001280641 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001280641 SMR P20605 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P20605 STRING 511145.b3361 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3361&targetmode=cogs STRING COG2184 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2184&targetmode=cogs SUPFAM SSF140931 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF140931 UniProtKB FIC_ECOLI http://www.uniprot.org/uniprot/FIC_ECOLI UniProtKB-AC P20605 http://www.uniprot.org/uniprot/P20605 charge swissprot:FIC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FIC_ECOLI eggNOG COG2184 http://eggnogapi.embl.de/nog_data/html/tree/COG2184 eggNOG ENOG4105MZU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105MZU epestfind swissprot:FIC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FIC_ECOLI garnier swissprot:FIC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FIC_ECOLI helixturnhelix swissprot:FIC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FIC_ECOLI hmoment swissprot:FIC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FIC_ECOLI iep swissprot:FIC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FIC_ECOLI inforesidue swissprot:FIC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FIC_ECOLI octanol swissprot:FIC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FIC_ECOLI pepcoil swissprot:FIC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FIC_ECOLI pepdigest swissprot:FIC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FIC_ECOLI pepinfo swissprot:FIC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FIC_ECOLI pepnet swissprot:FIC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FIC_ECOLI pepstats swissprot:FIC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FIC_ECOLI pepwheel swissprot:FIC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FIC_ECOLI pepwindow swissprot:FIC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FIC_ECOLI sigcleave swissprot:FIC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FIC_ECOLI ## Database ID URL or Descriptions # AltName PANB_ECOLI Ketopantoate hydroxymethyltransferase # BIOPHYSICOCHEMICAL PROPERTIES PANB_ECOLI Kinetic parameters KM=0.16 mM for ketopantoate {ECO 0000269|PubMed 6463}; KM=0.18 mM for L-tetrahydrofolate {ECO 0000269|PubMed 6463}; KM=1.0 mM for alpha-ketoisovalerate (at 37 degrees Celsius and pH 6.8) {ECO 0000269|PubMed 6463}; KM=2.9 mM for alpha-ketobutyrate (at 37 degrees Celsius and pH 6.8) {ECO 0000269|PubMed 6463}; KM=5.9 mM for formaldehyde {ECO 0000269|PubMed 6463}; KM=5.9 mM for alpha-keto-beta-methylvalerate (at 37 degrees Celsius and pH 6.8) {ECO 0000269|PubMed 6463}; KM=25 mM for alpha-ketovalerate (at 37 degrees Celsius and pH 6.8) {ECO 0000269|PubMed 6463}; Vmax=8.25 umol/min/mg enzyme for the forward reaction {ECO 0000269|PubMed 6463}; Vmax=7.3 umol/min/mg enzyme for the reverse reaction {ECO 0000269|PubMed 6463}; Vmax=4 umol/min/mg enzyme with alpha-ketobutyrate as substrate (at 37 degrees Celsius and pH 6.8) {ECO 0000269|PubMed 6463}; Vmax=2.8 umol/min/mg enzyme with alpha-ketoisovalerate as substrate (at 37 degrees Celsius and pH 6.8) {ECO 0000269|PubMed 6463}; Vmax=2 umol/min/mg enzyme with alpha-ketovalerate as substrate (at 37 degrees Celsius and pH 6.8) {ECO 0000269|PubMed 6463}; Vmax=0.43 umol/min/mg enzyme with alpha-keto-beta-methylvalerate as substrate (at 37 degrees Celsius and pH 6.8) {ECO 0000269|PubMed 6463}; pH dependence Optimum pH is 7.0-7.6. Stable from pH 5.0 to 10.0. Rapidly inactivated below pH 4.5. {ECO 0000269|PubMed 6463}; Temperature dependence Optimum temperature is 70-80 degrees Celsius. {ECO 0000269|PubMed 6463}; # BRENDA 2.1.2.11 2026 # BioGrid 4261383 245 # CATALYTIC ACTIVITY PANB_ECOLI 5,10-methylenetetrahydrofolate + 3-methyl-2- oxobutanoate + H(2)O = tetrahydrofolate + 2-dehydropantoate. # CDD cd06557 KPHMT-like # COFACTOR PANB_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 6463}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 6463}; Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000269|PubMed 6463}; Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 6463}; Note=Binds 1 Mg(2+) ion per subunit. Can also use Mn(2+), Co(2+) and Zn(2+) to a lesser extent. {ECO 0000269|PubMed 6463}; # ENZYME REGULATION Inhibited by isovalerate, pyruvate, 3-methyl-2- butanone, and valine. Partially inhibited by formaldehyde and tetrahydrofolate below or near the KM value. Also inhibited by later intermediates pantoate, pantothenate and coenzyme A. {ECO:0000269|PubMed 6463}. # EcoGene EG11675 panB # FUNCTION PANB_ECOLI Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate. {ECO 0000269|PubMed 776976}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0003864 3-methyl-2-oxobutanoate hydroxymethyltransferase activity; IDA:EcoCyc. # GO_process GO:0033317 pantothenate biosynthetic process from valine; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.20.20.60 -; 1. # HAMAP MF_00156 PanB # IntAct P31057 8 # InterPro IPR003700 Pantoate_hydroxy_MeTrfase # InterPro IPR015813 Pyrv/PenolPyrv_Kinase-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00770 Pantothenate and CoA biosynthesis # MASS SPECTROMETRY Mass=28234; Method=Electrospray; Range=1-264; Evidence={ECO:0000269|PubMed 12906829}; # Organism PANB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR20881 PTHR20881 # PATHWAY Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate step 1/2. # PATRIC 32115373 VBIEscCol129921_0138 # PDB 1M3U X-ray; 1.80 A; A/B/C/D/E/F/G/H/I/J=1-264 # PIR F64736 F64736 # PIRSF PIRSF000388 Pantoate_hydroxy_MeTrfase # Pfam PF02548 Pantoate_transf # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PANB_ECOLI 3-methyl-2-oxobutanoate hydroxymethyltransferase # RefSeq NP_414676 NC_000913.3 # RefSeq WP_000805497 NZ_LN832404.1 # SIMILARITY Belongs to the PanB family. {ECO 0000305}. # SUBCELLULAR LOCATION PANB_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT PANB_ECOLI Homodecamer; pentamer of dimers. {ECO 0000269|PubMed 12906829, ECO 0000269|PubMed 6463}. # SUPFAM SSF51621 SSF51621 # TIGRFAMs TIGR00222 panB # UniPathway UPA00028 UER00003 # eggNOG COG0413 LUCA # eggNOG ENOG4105CCG Bacteria BLAST swissprot:PANB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PANB_ECOLI BioCyc ECOL316407:JW0130-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0130-MONOMER BioCyc EcoCyc:3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-MONOMER http://biocyc.org/getid?id=EcoCyc:3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-MONOMER BioCyc MetaCyc:3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-MONOMER http://biocyc.org/getid?id=MetaCyc:3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-MONOMER COG COG0413 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0413 DIP DIP-10436N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10436N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1016/S0969-2126(03)00158-8 http://dx.doi.org/10.1016/S0969-2126(03)00158-8 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.2.11 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.2.11 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L17086 http://www.ebi.ac.uk/ena/data/view/L17086 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X65538 http://www.ebi.ac.uk/ena/data/view/X65538 ENZYME 2.1.2.11 http://enzyme.expasy.org/EC/2.1.2.11 EchoBASE EB1626 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1626 EcoGene EG11675 http://www.ecogene.org/geneInfo.php?eg_id=EG11675 EnsemblBacteria AAC73245 http://www.ensemblgenomes.org/id/AAC73245 EnsemblBacteria AAC73245 http://www.ensemblgenomes.org/id/AAC73245 EnsemblBacteria BAB96711 http://www.ensemblgenomes.org/id/BAB96711 EnsemblBacteria BAB96711 http://www.ensemblgenomes.org/id/BAB96711 EnsemblBacteria BAB96711 http://www.ensemblgenomes.org/id/BAB96711 EnsemblBacteria b0134 http://www.ensemblgenomes.org/id/b0134 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0003864 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003864 GO_process GO:0033317 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033317 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.20.20.60 http://www.cathdb.info/version/latest/superfamily/3.20.20.60 GeneID 944839 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944839 HAMAP MF_00156 http://hamap.expasy.org/unirule/MF_00156 HOGENOM HOG000078427 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000078427&db=HOGENOM6 InParanoid P31057 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31057 IntAct P31057 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31057* IntEnz 2.1.2.11 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.2.11 InterPro IPR003700 http://www.ebi.ac.uk/interpro/entry/IPR003700 InterPro IPR015813 http://www.ebi.ac.uk/interpro/entry/IPR015813 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0130 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0130 KEGG_Gene eco:b0134 http://www.genome.jp/dbget-bin/www_bget?eco:b0134 KEGG_Orthology KO:K00606 http://www.genome.jp/dbget-bin/www_bget?KO:K00606 KEGG_Pathway ko00770 http://www.genome.jp/kegg-bin/show_pathway?ko00770 KEGG_Reaction rn:R01226 http://www.genome.jp/dbget-bin/www_bget?rn:R01226 MINT MINT-1249247 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1249247 OMA QMAYHTE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QMAYHTE PANTHER PTHR20881 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20881 PDB 1M3U http://www.ebi.ac.uk/pdbe-srv/view/entry/1M3U PDBsum 1M3U http://www.ebi.ac.uk/pdbsum/1M3U PSORT swissprot:PANB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PANB_ECOLI PSORT-B swissprot:PANB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PANB_ECOLI PSORT2 swissprot:PANB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PANB_ECOLI Pfam PF02548 http://pfam.xfam.org/family/PF02548 Phobius swissprot:PANB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PANB_ECOLI PhylomeDB P31057 http://phylomedb.org/?seqid=P31057 ProteinModelPortal P31057 http://www.proteinmodelportal.org/query/uniprot/P31057 PubMed 12906829 http://www.ncbi.nlm.nih.gov/pubmed/12906829 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6463 http://www.ncbi.nlm.nih.gov/pubmed/6463 PubMed 776976 http://www.ncbi.nlm.nih.gov/pubmed/776976 PubMed 8096212 http://www.ncbi.nlm.nih.gov/pubmed/8096212 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_414676 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414676 RefSeq WP_000805497 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000805497 SMR P31057 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31057 STRING 511145.b0134 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0134&targetmode=cogs STRING COG0413 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0413&targetmode=cogs SUPFAM SSF51621 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51621 TIGRFAMs TIGR00222 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00222 UniProtKB PANB_ECOLI http://www.uniprot.org/uniprot/PANB_ECOLI UniProtKB-AC P31057 http://www.uniprot.org/uniprot/P31057 charge swissprot:PANB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PANB_ECOLI eggNOG COG0413 http://eggnogapi.embl.de/nog_data/html/tree/COG0413 eggNOG ENOG4105CCG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CCG epestfind swissprot:PANB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PANB_ECOLI garnier swissprot:PANB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PANB_ECOLI helixturnhelix swissprot:PANB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PANB_ECOLI hmoment swissprot:PANB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PANB_ECOLI iep swissprot:PANB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PANB_ECOLI inforesidue swissprot:PANB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PANB_ECOLI octanol swissprot:PANB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PANB_ECOLI pepcoil swissprot:PANB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PANB_ECOLI pepdigest swissprot:PANB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PANB_ECOLI pepinfo swissprot:PANB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PANB_ECOLI pepnet swissprot:PANB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PANB_ECOLI pepstats swissprot:PANB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PANB_ECOLI pepwheel swissprot:PANB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PANB_ECOLI pepwindow swissprot:PANB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PANB_ECOLI sigcleave swissprot:PANB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PANB_ECOLI ## Database ID URL or Descriptions # AltName APPB_ECOLI Cytochrome bd-II oxidase subunit II # BRENDA 1.10.3.14 2026 # BioGrid 4260034 136 # CATALYTIC ACTIVITY APPB_ECOLI 2 ubiquinol + O(2) + n H(+)(Side 1) = 2 ubiquinone + 2 H(2)O + n H(+)(Side 2). # CAUTION Was originally thought not to translocate protons. {ECO:0000305|PubMed 19542282}. # COFACTOR APPB_ECOLI Name=heme; Xref=ChEBI CHEBI 30413; Evidence={ECO 0000305}; Note=May bind up to 3 heme groups per complex. {ECO 0000305}; # DISRUPTION PHENOTYPE APPB_ECOLI 3-fold decreased ubiquinone levels but no change in redox levels of the ubiquinone pool (in aerobically grown minimal medium with glucose). {ECO 0000269|PubMed 19542282, ECO 0000269|PubMed 21987791, ECO 0000269|PubMed 22843529}. # ENZYME REGULATION Inhibited by cyanide; is more sensitive to cyanide than cytochrome bd-I oxidase. {ECO:0000269|PubMed 8626304}. # EcoGene EG11379 appB # FUNCTION APPB_ECOLI A terminal oxidase that catalyzes quinol-dependent, Na(+)-independent oxygen uptake. Prefers menadiol over other quinols although ubiquinol was not tested (PubMed 8626304). Generates a proton motive force using protons and electrons from opposite sides of the membrane to generate H(2)O, transferring 1 proton/electron. {ECO 0000269|PubMed 19542282, ECO 0000269|PubMed 21987791, ECO 0000269|PubMed 22843529, ECO 0000269|PubMed 8626304}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_component GO:0070069 cytochrome complex; IDA:EcoCyc. # GO_function GO:0009055 electron carrier activity; IDA:EcoCyc. # GO_function GO:0016682 oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006119 oxidative phosphorylation; IEA:UniProtKB-UniPathway. # GO_process GO:0019646 aerobic electron transport chain; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # INDUCTION Induced when bacterial cultures reach stationary phase; synthesis is triggered by phosphate starvation or a shift from aerobic to anaerobic conditions. {ECO:0000269|PubMed 1658595}. # InterPro IPR003317 Cyt-d_oxidase_su2 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00190 Oxidative phosphorylation # KEGG_Pathway ko02020 Two-component system # Organism APPB_ECOLI Escherichia coli (strain K12) # PATHWAY APPB_ECOLI Energy metabolism; oxidative phosphorylation. # PATRIC 32117179 VBIEscCol129921_1013 # PIRSF PIRSF000267 Cyt_oxidse_sub2 # Pfam PF02322 Cyt_bd_oxida_II # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName APPB_ECOLI Cytochrome bd-II ubiquinol oxidase subunit 2 # RefSeq NP_415498 NC_000913.3 # RefSeq WP_000460803 NZ_LN832404.1 # SIMILARITY Belongs to the cytochrome ubiquinol oxidase subunit 2 family. {ECO 0000305}. # SUBCELLULAR LOCATION APPB_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # SUBUNIT Heterodimer of subunits I and II. {ECO:0000305|PubMed 8626304}. # TIGRFAMs TIGR00203 cydB # eggNOG COG1294 LUCA # eggNOG ENOG4105CFY Bacteria BLAST swissprot:APPB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:APPB_ECOLI BioCyc ECOL316407:JW0961-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0961-MONOMER BioCyc EcoCyc:APPB-MONOMER http://biocyc.org/getid?id=EcoCyc:APPB-MONOMER BioCyc MetaCyc:APPB-MONOMER http://biocyc.org/getid?id=MetaCyc:APPB-MONOMER COG COG1294 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1294 DOI 10.1007/BF00267454 http://dx.doi.org/10.1007/BF00267454 DOI 10.1016/j.bbabio.2011.06.016 http://dx.doi.org/10.1016/j.bbabio.2011.06.016 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.1108217108 http://dx.doi.org/10.1073/pnas.1108217108 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AEM.01507-12 http://dx.doi.org/10.1128/AEM.01507-12 DOI 10.1128/JB.00562-09 http://dx.doi.org/10.1128/JB.00562-09 EC_number EC:1.10.3.10 http://www.genome.jp/dbget-bin/www_bget?EC:1.10.3.10 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL S63811 http://www.ebi.ac.uk/ena/data/view/S63811 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.10.3.10 http://enzyme.expasy.org/EC/1.10.3.10 EchoBASE EB1353 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1353 EcoGene EG11379 http://www.ecogene.org/geneInfo.php?eg_id=EG11379 EnsemblBacteria AAC74064 http://www.ensemblgenomes.org/id/AAC74064 EnsemblBacteria AAC74064 http://www.ensemblgenomes.org/id/AAC74064 EnsemblBacteria BAA35744 http://www.ensemblgenomes.org/id/BAA35744 EnsemblBacteria BAA35744 http://www.ensemblgenomes.org/id/BAA35744 EnsemblBacteria BAA35744 http://www.ensemblgenomes.org/id/BAA35744 EnsemblBacteria b0979 http://www.ensemblgenomes.org/id/b0979 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0070069 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070069 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0016682 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016682 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006119 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006119 GO_process GO:0019646 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019646 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 947547 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947547 HOGENOM HOG000084824 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000084824&db=HOGENOM6 InParanoid P26458 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P26458 IntAct P26458 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P26458* IntEnz 1.10.3.10 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.10.3.10 InterPro IPR003317 http://www.ebi.ac.uk/interpro/entry/IPR003317 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0961 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0961 KEGG_Gene eco:b0979 http://www.genome.jp/dbget-bin/www_bget?eco:b0979 KEGG_Orthology KO:K00426 http://www.genome.jp/dbget-bin/www_bget?KO:K00426 KEGG_Pathway ko00190 http://www.genome.jp/kegg-bin/show_pathway?ko00190 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA RIHYIAT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RIHYIAT PSORT swissprot:APPB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:APPB_ECOLI PSORT-B swissprot:APPB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:APPB_ECOLI PSORT2 swissprot:APPB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:APPB_ECOLI Pfam PF02322 http://pfam.xfam.org/family/PF02322 Phobius swissprot:APPB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:APPB_ECOLI PhylomeDB P26458 http://phylomedb.org/?seqid=P26458 ProteinModelPortal P26458 http://www.proteinmodelportal.org/query/uniprot/P26458 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 1658595 http://www.ncbi.nlm.nih.gov/pubmed/1658595 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19542282 http://www.ncbi.nlm.nih.gov/pubmed/19542282 PubMed 21756872 http://www.ncbi.nlm.nih.gov/pubmed/21756872 PubMed 21987791 http://www.ncbi.nlm.nih.gov/pubmed/21987791 PubMed 22843529 http://www.ncbi.nlm.nih.gov/pubmed/22843529 PubMed 8626304 http://www.ncbi.nlm.nih.gov/pubmed/8626304 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415498 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415498 RefSeq WP_000460803 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000460803 STRING 511145.b0979 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0979&targetmode=cogs STRING COG1294 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1294&targetmode=cogs TIGRFAMs TIGR00203 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00203 UniProtKB APPB_ECOLI http://www.uniprot.org/uniprot/APPB_ECOLI UniProtKB-AC P26458 http://www.uniprot.org/uniprot/P26458 charge swissprot:APPB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:APPB_ECOLI eggNOG COG1294 http://eggnogapi.embl.de/nog_data/html/tree/COG1294 eggNOG ENOG4105CFY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CFY epestfind swissprot:APPB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:APPB_ECOLI garnier swissprot:APPB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:APPB_ECOLI helixturnhelix swissprot:APPB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:APPB_ECOLI hmoment swissprot:APPB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:APPB_ECOLI iep swissprot:APPB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:APPB_ECOLI inforesidue swissprot:APPB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:APPB_ECOLI octanol swissprot:APPB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:APPB_ECOLI pepcoil swissprot:APPB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:APPB_ECOLI pepdigest swissprot:APPB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:APPB_ECOLI pepinfo swissprot:APPB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:APPB_ECOLI pepnet swissprot:APPB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:APPB_ECOLI pepstats swissprot:APPB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:APPB_ECOLI pepwheel swissprot:APPB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:APPB_ECOLI pepwindow swissprot:APPB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:APPB_ECOLI sigcleave swissprot:APPB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:APPB_ECOLI ## Database ID URL or Descriptions # AltName Fructose-like phosphotransferase enzyme IIB component 3 {ECO:0000250|UniProtKB P20966} # BioGrid 4263010 6 # CATALYTIC ACTIVITY [Protein]-N(pi)-phospho-L-histidine + D- fructose(Side 1) = [protein]-L-histidine + D-fructose 1- phosphate(Side 2). {ECO:0000250|UniProtKB P20966}. # CDD cd05569 PTS_IIB_fructose # DOMAIN PTFB3_ECOLI The PTS EIIB type-2 domain is phosphorylated by phospho- EIIA on a cysteinyl residue. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the PTS EIIC type-2 domain. {ECO 0000255|PROSITE- ProRule PRU00422}. # EcoGene EG11912 frwD # FUNCTION PTFB3_ECOLI The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. {ECO 0000250|UniProtKB P20966, ECO 0000305|PubMed 7773398}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0016301 kinase activity; IEA:UniProtKB-KW. # GO_function GO:0022877 protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity; IEA:InterPro. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; ISA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # IntAct P32676 2 # InterPro IPR003353 PTS_IIB_fruc # InterPro IPR003501 PTS_EIIB_2/3 # InterPro IPR013011 PTS_EIIB_2 # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00306 PTS system, fructose-specific II-like component # KEGG_Brite ko02000 Transporters # Organism PTFB3_ECOLI Escherichia coli (strain K12) # PATRIC 32123427 VBIEscCol129921_4074 # PDB 4TN5 X-ray; 2.29 A; A/B=1-113 # PIR D65202 D65202 # PROSITE PS51099 PTS_EIIB_TYPE_2 # Pfam PF02302 PTS_IIB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PTS system fructose-like EIIB component 3 {ECO:0000250|UniProtKB P20966} # RefSeq NP_418388 NC_000913.3 # RefSeq WP_000323846 NZ_LN832404.1 # SIMILARITY Contains 1 PTS EIIB type-2 domain. {ECO:0000255|PROSITE-ProRule PRU00422}. # SUBCELLULAR LOCATION PTFB3_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF52794 SSF52794 # TCDB 4.A.2.1.10 the pts fructose-mannitol (fru) family # TIGRFAMs TIGR00829 FRU # eggNOG COG1445 LUCA # eggNOG ENOG4108XCZ Bacteria BLAST swissprot:PTFB3_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTFB3_ECOLI BioCyc ECOL316407:JW3925-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3925-MONOMER BioCyc EcoCyc:EG11912-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11912-MONOMER COG COG1445 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1445 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1099/13500872-141-4-961 http://dx.doi.org/10.1099/13500872-141-4-961 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.202 {ECO:0000250|UniProtKB:P20966} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.202 {ECO:0000250|UniProtKB:P20966} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.202 {ECO:0000250|UniProtKB:P20966} http://enzyme.expasy.org/EC/2.7.1.202 {ECO:0000250|UniProtKB:P20966} EchoBASE EB1856 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1856 EcoGene EG11912 http://www.ecogene.org/geneInfo.php?eg_id=EG11912 EnsemblBacteria AAC76935 http://www.ensemblgenomes.org/id/AAC76935 EnsemblBacteria AAC76935 http://www.ensemblgenomes.org/id/AAC76935 EnsemblBacteria BAE77358 http://www.ensemblgenomes.org/id/BAE77358 EnsemblBacteria BAE77358 http://www.ensemblgenomes.org/id/BAE77358 EnsemblBacteria BAE77358 http://www.ensemblgenomes.org/id/BAE77358 EnsemblBacteria b3953 http://www.ensemblgenomes.org/id/b3953 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_function GO:0022877 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022877 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948452 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948452 HOGENOM HOG000231313 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231313&db=HOGENOM6 IntAct P32676 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32676* IntEnz 2.7.1.202 {ECO:0000250|UniProtKB:P20966} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.202 {ECO:0000250|UniProtKB:P20966} InterPro IPR003353 http://www.ebi.ac.uk/interpro/entry/IPR003353 InterPro IPR003501 http://www.ebi.ac.uk/interpro/entry/IPR003501 InterPro IPR013011 http://www.ebi.ac.uk/interpro/entry/IPR013011 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3925 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3925 KEGG_Gene eco:b3953 http://www.genome.jp/dbget-bin/www_bget?eco:b3953 KEGG_Orthology KO:K11202 http://www.genome.jp/dbget-bin/www_bget?KO:K11202 OMA CQQEKWN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CQQEKWN PDB 4TN5 http://www.ebi.ac.uk/pdbe-srv/view/entry/4TN5 PDBsum 4TN5 http://www.ebi.ac.uk/pdbsum/4TN5 PROSITE PS51099 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51099 PSORT swissprot:PTFB3_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTFB3_ECOLI PSORT-B swissprot:PTFB3_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTFB3_ECOLI PSORT2 swissprot:PTFB3_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTFB3_ECOLI Pfam PF02302 http://pfam.xfam.org/family/PF02302 Phobius swissprot:PTFB3_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTFB3_ECOLI PhylomeDB P32676 http://phylomedb.org/?seqid=P32676 ProteinModelPortal P32676 http://www.proteinmodelportal.org/query/uniprot/P32676 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7773398 http://www.ncbi.nlm.nih.gov/pubmed/7773398 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418388 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418388 RefSeq WP_000323846 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000323846 SMR P32676 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32676 STRING 511145.b3953 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3953&targetmode=cogs STRING COG1445 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1445&targetmode=cogs SUPFAM SSF52794 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52794 TCDB 4.A.2.1.10 http://www.tcdb.org/search/result.php?tc=4.A.2.1.10 TIGRFAMs TIGR00829 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00829 UniProtKB PTFB3_ECOLI http://www.uniprot.org/uniprot/PTFB3_ECOLI UniProtKB-AC P32676 http://www.uniprot.org/uniprot/P32676 charge swissprot:PTFB3_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTFB3_ECOLI eggNOG COG1445 http://eggnogapi.embl.de/nog_data/html/tree/COG1445 eggNOG ENOG4108XCZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108XCZ epestfind swissprot:PTFB3_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTFB3_ECOLI garnier swissprot:PTFB3_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTFB3_ECOLI helixturnhelix swissprot:PTFB3_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTFB3_ECOLI hmoment swissprot:PTFB3_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTFB3_ECOLI iep swissprot:PTFB3_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTFB3_ECOLI inforesidue swissprot:PTFB3_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTFB3_ECOLI octanol swissprot:PTFB3_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTFB3_ECOLI pepcoil swissprot:PTFB3_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTFB3_ECOLI pepdigest swissprot:PTFB3_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTFB3_ECOLI pepinfo swissprot:PTFB3_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTFB3_ECOLI pepnet swissprot:PTFB3_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTFB3_ECOLI pepstats swissprot:PTFB3_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTFB3_ECOLI pepwheel swissprot:PTFB3_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTFB3_ECOLI pepwindow swissprot:PTFB3_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTFB3_ECOLI sigcleave swissprot:PTFB3_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTFB3_ECOLI ## Database ID URL or Descriptions # BioGrid 4262113 6 # EcoGene EG14264 cbl # FUNCTION CBL_ECOLI May be an accessory regulatory protein within the cys regulon. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045883 positive regulation of sulfur utilization; IDA:EcoliWiki. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # IntAct Q47083 2 # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR005119 LysR_subst-bd # InterPro IPR011991 WHTH_DNA-bd_dom # KEGG_Brite ko03000 Transcription factors # Organism CBL_ECOLI Escherichia coli (strain K12) # PATRIC 32119305 VBIEscCol129921_2063 # PDB 2FYI X-ray; 2.80 A; A/B/C/D=88-307 # PIR C64963 C64963 # PRINTS PR00039 HTHLYSR # PROSITE PS50931 HTH_LYSR # Pfam PF00126 HTH_1 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CBL_ECOLI HTH-type transcriptional regulator cbl # RefSeq NP_416492 NC_000913.3 # RefSeq WP_001011008 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lysR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00253}. # SUPFAM SSF46785 SSF46785 # eggNOG ENOG4107R11 Bacteria # eggNOG ENOG410XP61 LUCA BLAST swissprot:CBL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CBL_ECOLI BioCyc ECOL316407:JW1966-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1966-MONOMER BioCyc EcoCyc:G7071-MONOMER http://biocyc.org/getid?id=EcoCyc:G7071-MONOMER COG COG0583 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0583 DIP DIP-9248N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9248N DOI 10.1016/0378-1119(95)00606-8 http://dx.doi.org/10.1016/0378-1119(95)00606-8 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L31639 http://www.ebi.ac.uk/ena/data/view/L31639 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4012 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4012 EcoGene EG14264 http://www.ecogene.org/geneInfo.php?eg_id=EG14264 EnsemblBacteria AAC75049 http://www.ensemblgenomes.org/id/AAC75049 EnsemblBacteria AAC75049 http://www.ensemblgenomes.org/id/AAC75049 EnsemblBacteria BAA15805 http://www.ensemblgenomes.org/id/BAA15805 EnsemblBacteria BAA15805 http://www.ensemblgenomes.org/id/BAA15805 EnsemblBacteria BAA15805 http://www.ensemblgenomes.org/id/BAA15805 EnsemblBacteria b1987 http://www.ensemblgenomes.org/id/b1987 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045883 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045883 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 946502 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946502 HOGENOM HOG000260068 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260068&db=HOGENOM6 InParanoid Q47083 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q47083 IntAct Q47083 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q47083* InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW1966 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1966 KEGG_Gene eco:b1987 http://www.genome.jp/dbget-bin/www_bget?eco:b1987 KEGG_Orthology KO:K13635 http://www.genome.jp/dbget-bin/www_bget?KO:K13635 OMA KVNISLH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KVNISLH PDB 2FYI http://www.ebi.ac.uk/pdbe-srv/view/entry/2FYI PDBsum 2FYI http://www.ebi.ac.uk/pdbsum/2FYI PRINTS PR00039 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00039 PROSITE PS50931 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50931 PSORT swissprot:CBL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CBL_ECOLI PSORT-B swissprot:CBL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CBL_ECOLI PSORT2 swissprot:CBL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CBL_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:CBL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CBL_ECOLI PhylomeDB Q47083 http://phylomedb.org/?seqid=Q47083 ProteinModelPortal Q47083 http://www.proteinmodelportal.org/query/uniprot/Q47083 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8529872 http://www.ncbi.nlm.nih.gov/pubmed/8529872 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416492 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416492 RefSeq WP_001011008 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001011008 SMR Q47083 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q47083 STRING 511145.b1987 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1987&targetmode=cogs STRING COG0583 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0583&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB CBL_ECOLI http://www.uniprot.org/uniprot/CBL_ECOLI UniProtKB-AC Q47083 http://www.uniprot.org/uniprot/Q47083 charge swissprot:CBL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CBL_ECOLI eggNOG ENOG4107R11 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107R11 eggNOG ENOG410XP61 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XP61 epestfind swissprot:CBL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CBL_ECOLI garnier swissprot:CBL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CBL_ECOLI helixturnhelix swissprot:CBL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CBL_ECOLI hmoment swissprot:CBL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CBL_ECOLI iep swissprot:CBL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CBL_ECOLI inforesidue swissprot:CBL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CBL_ECOLI octanol swissprot:CBL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CBL_ECOLI pepcoil swissprot:CBL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CBL_ECOLI pepdigest swissprot:CBL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CBL_ECOLI pepinfo swissprot:CBL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CBL_ECOLI pepnet swissprot:CBL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CBL_ECOLI pepstats swissprot:CBL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CBL_ECOLI pepwheel swissprot:CBL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CBL_ECOLI pepwindow swissprot:CBL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CBL_ECOLI sigcleave swissprot:CBL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CBL_ECOLI ## Database ID URL or Descriptions # AltName CDAR_ECOLI Sugar diacid regulator # BioGrid 4260992 4 # EcoGene EG12335 cdaR # FUNCTION CDAR_ECOLI Seems to regulate the expression of the operons for the enzymes involved in D-galactarate, D-glucarate and D-glycerate utilization. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IMP:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IMP:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.60 -; 1. # InterPro IPR008599 Diacid_rec # InterPro IPR009057 Homeodomain-like # InterPro IPR025736 PucR_C-HTH_dom # KEGG_Brite ko03000 Transcription factors # Organism CDAR_ECOLI Escherichia coli (strain K12) # PATRIC 32115433 VBIEscCol129921_0168 # PIR B64740 B64740 # Pfam PF05651 Diacid_rec # Pfam PF13556 HTH_30 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CDAR_ECOLI Carbohydrate diacid regulator # RefSeq NP_414704 NC_000913.3 # RefSeq WP_000929443 NZ_LN832404.1 # SIMILARITY Belongs to the CdaR family. {ECO 0000305}. # eggNOG COG3835 LUCA # eggNOG ENOG4108IXP Bacteria BLAST swissprot:CDAR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CDAR_ECOLI BioCyc ECOL316407:JW5013-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5013-MONOMER BioCyc EcoCyc:EG12335-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12335-MONOMER COG COG3835 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3835 DIP DIP-9258N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9258N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.9.2672-2674.2000 http://dx.doi.org/10.1128/JB.182.9.2672-2674.2000 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EchoBASE EB2239 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2239 EcoGene EG12335 http://www.ecogene.org/geneInfo.php?eg_id=EG12335 EnsemblBacteria AAC73273 http://www.ensemblgenomes.org/id/AAC73273 EnsemblBacteria AAC73273 http://www.ensemblgenomes.org/id/AAC73273 EnsemblBacteria BAB96739 http://www.ensemblgenomes.org/id/BAB96739 EnsemblBacteria BAB96739 http://www.ensemblgenomes.org/id/BAB96739 EnsemblBacteria BAB96739 http://www.ensemblgenomes.org/id/BAB96739 EnsemblBacteria b0162 http://www.ensemblgenomes.org/id/b0162 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 GeneID 944860 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944860 HOGENOM HOG000271795 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000271795&db=HOGENOM6 InParanoid P37047 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37047 InterPro IPR008599 http://www.ebi.ac.uk/interpro/entry/IPR008599 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR025736 http://www.ebi.ac.uk/interpro/entry/IPR025736 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW5013 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5013 KEGG_Gene eco:b0162 http://www.genome.jp/dbget-bin/www_bget?eco:b0162 KEGG_Orthology KO:K02647 http://www.genome.jp/dbget-bin/www_bget?KO:K02647 OMA NTRHEGA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NTRHEGA PSORT swissprot:CDAR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CDAR_ECOLI PSORT-B swissprot:CDAR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CDAR_ECOLI PSORT2 swissprot:CDAR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CDAR_ECOLI Pfam PF05651 http://pfam.xfam.org/family/PF05651 Pfam PF13556 http://pfam.xfam.org/family/PF13556 Phobius swissprot:CDAR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CDAR_ECOLI PhylomeDB P37047 http://phylomedb.org/?seqid=P37047 ProteinModelPortal P37047 http://www.proteinmodelportal.org/query/uniprot/P37047 PubMed 10762278 http://www.ncbi.nlm.nih.gov/pubmed/10762278 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414704 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414704 RefSeq WP_000929443 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000929443 SMR P37047 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37047 STRING 511145.b0162 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0162&targetmode=cogs STRING COG3835 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3835&targetmode=cogs UniProtKB CDAR_ECOLI http://www.uniprot.org/uniprot/CDAR_ECOLI UniProtKB-AC P37047 http://www.uniprot.org/uniprot/P37047 charge swissprot:CDAR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CDAR_ECOLI eggNOG COG3835 http://eggnogapi.embl.de/nog_data/html/tree/COG3835 eggNOG ENOG4108IXP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108IXP epestfind swissprot:CDAR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CDAR_ECOLI garnier swissprot:CDAR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CDAR_ECOLI helixturnhelix swissprot:CDAR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CDAR_ECOLI hmoment swissprot:CDAR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CDAR_ECOLI iep swissprot:CDAR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CDAR_ECOLI inforesidue swissprot:CDAR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CDAR_ECOLI octanol swissprot:CDAR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CDAR_ECOLI pepcoil swissprot:CDAR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CDAR_ECOLI pepdigest swissprot:CDAR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CDAR_ECOLI pepinfo swissprot:CDAR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CDAR_ECOLI pepnet swissprot:CDAR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CDAR_ECOLI pepstats swissprot:CDAR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CDAR_ECOLI pepwheel swissprot:CDAR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CDAR_ECOLI pepwindow swissprot:CDAR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CDAR_ECOLI sigcleave swissprot:CDAR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CDAR_ECOLI ## Database ID URL or Descriptions # BioGrid 4263115 9 # EcoGene EG13028 ygiZ # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # IntAct Q46867 3 # InterPro IPR022553 DUF2645 # Organism YGIZ_ECOLI Escherichia coli (strain K12) # PIR A65090 A65090 # Pfam PF10840 DUF2645 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGIZ_ECOLI Inner membrane protein YgiZ # RefSeq NP_417499 NC_000913.3 # RefSeq WP_000917684 NZ_LN832404.1 # SUBCELLULAR LOCATION YGIZ_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG ENOG4107DEU Bacteria # eggNOG ENOG410Z1FQ LUCA BLAST swissprot:YGIZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGIZ_ECOLI BioCyc ECOL316407:JW2995-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2995-MONOMER BioCyc EcoCyc:G7577-MONOMER http://biocyc.org/getid?id=EcoCyc:G7577-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2846 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2846 EcoGene EG13028 http://www.ecogene.org/geneInfo.php?eg_id=EG13028 EnsemblBacteria AAC76063 http://www.ensemblgenomes.org/id/AAC76063 EnsemblBacteria AAC76063 http://www.ensemblgenomes.org/id/AAC76063 EnsemblBacteria BAE77083 http://www.ensemblgenomes.org/id/BAE77083 EnsemblBacteria BAE77083 http://www.ensemblgenomes.org/id/BAE77083 EnsemblBacteria BAE77083 http://www.ensemblgenomes.org/id/BAE77083 EnsemblBacteria b3027 http://www.ensemblgenomes.org/id/b3027 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 946450 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946450 HOGENOM HOG000125035 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125035&db=HOGENOM6 IntAct Q46867 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46867* InterPro IPR022553 http://www.ebi.ac.uk/interpro/entry/IPR022553 KEGG_Gene ecj:JW2995 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2995 KEGG_Gene eco:b3027 http://www.genome.jp/dbget-bin/www_bget?eco:b3027 OMA SICSIPH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SICSIPH PSORT swissprot:YGIZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGIZ_ECOLI PSORT-B swissprot:YGIZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGIZ_ECOLI PSORT2 swissprot:YGIZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGIZ_ECOLI Pfam PF10840 http://pfam.xfam.org/family/PF10840 Phobius swissprot:YGIZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGIZ_ECOLI ProteinModelPortal Q46867 http://www.proteinmodelportal.org/query/uniprot/Q46867 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417499 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417499 RefSeq WP_000917684 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000917684 STRING 511145.b3027 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3027&targetmode=cogs UniProtKB YGIZ_ECOLI http://www.uniprot.org/uniprot/YGIZ_ECOLI UniProtKB-AC Q46867 http://www.uniprot.org/uniprot/Q46867 charge swissprot:YGIZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGIZ_ECOLI eggNOG ENOG4107DEU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107DEU eggNOG ENOG410Z1FQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Z1FQ epestfind swissprot:YGIZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGIZ_ECOLI garnier swissprot:YGIZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGIZ_ECOLI helixturnhelix swissprot:YGIZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGIZ_ECOLI hmoment swissprot:YGIZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGIZ_ECOLI iep swissprot:YGIZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGIZ_ECOLI inforesidue swissprot:YGIZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGIZ_ECOLI octanol swissprot:YGIZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGIZ_ECOLI pepcoil swissprot:YGIZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGIZ_ECOLI pepdigest swissprot:YGIZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGIZ_ECOLI pepinfo swissprot:YGIZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGIZ_ECOLI pepnet swissprot:YGIZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGIZ_ECOLI pepstats swissprot:YGIZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGIZ_ECOLI pepwheel swissprot:YGIZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGIZ_ECOLI pepwindow swissprot:YGIZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGIZ_ECOLI sigcleave swissprot:YGIZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGIZ_ECOLI ## Database ID URL or Descriptions # AltName ROXA_ECOLI Ribosomal oxygenase RoxA # BioGrid 4260093 7 # CATALYTIC ACTIVITY [50S ribosomal protein L16]-L-Arg(81) + 2- oxoglutarate + O(2) = [50S ribosomal protein L16]-(3R)-3-hydroxy- L-Arg(81) + succinate + CO(2). {ECO:0000269|PubMed 23103944}. # COFACTOR ROXA_ECOLI Name=Fe(2+); Xref=ChEBI CHEBI 29033; Evidence={ECO 0000269|PubMed 24530688}; Note=Binds 1 Fe(2+) ion per subunit. {ECO 0000269|PubMed 24530688}; # DISRUPTION PHENOTYPE Cells lacking this gene grow similarly as wild-type under standard conditions, but show reduced growth under low nutrient conditions; this result correlates with a bulk protein translation rate that is lower by a factor of three or four in the deletion mutant strain than that in the wild-type. Deletion of this gene also leads to loss of Rpl16 hydroxylation. {ECO:0000269|PubMed 23103944}. # EcoGene EG11430 roxA # FUNCTION ROXA_ECOLI Growth-regulating oxygenase that catalyzes the hydroxylation of 50S ribosomal protein L16 on 'Arg-81'. {ECO 0000269|PubMed 23103944, ECO 0000269|PubMed 24530688}. # GO_function GO:0008198 ferrous iron binding; IDA:EcoCyc. # GO_function GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; IDA:EcoCyc. # GO_process GO:0030961 peptidyl-arginine hydroxylation; IMP:EcoCyc. # GO_process GO:0042254 ribosome biogenesis; IBA:GO_Central. # GO_process GO:0043687 post-translational protein modification; IMP:EcoCyc. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0042254 ribosome biogenesis # IntAct P27431 12 # InterPro IPR003347 JmjC_dom # Organism ROXA_ECOLI Escherichia coli (strain K12) # PATRIC 32117505 VBIEscCol129921_1175 # PDB 4CCL X-ray; 2.60 A; A/B=1-373 # PDB 4LIT X-ray; 2.40 A; A=1-373 # PDB 4LIU X-ray; 2.70 A; A=2-373 # PDB 4LIV X-ray; 2.70 A; A=1-373 # PDB 4NUB X-ray; 2.70 A; A=1-373 # PIR E64857 E64857 # PROSITE PS51184 JMJC # Pfam PF08007 Cupin_4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 50S ribosomal protein L16 3-hydroxylase {ECO 0000305} # RefSeq NP_415646 NC_000913.3 # RefSeq WP_000456506 NZ_LN832404.1 # SIMILARITY Belongs to the ROX family. RoxA/YcfD subfamily. {ECO 0000305}. # SIMILARITY Contains 1 JmjC domain. {ECO:0000255|PROSITE- ProRule PRU00538}. # SMART SM00558 JmjC # SUBUNIT ROXA_ECOLI Homodimer. {ECO 0000269|PubMed 24530688, ECO 0000269|PubMed 24814345}. # eggNOG COG2850 LUCA # eggNOG ENOG4105EZE Bacteria BLAST swissprot:ROXA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ROXA_ECOLI BioCyc ECOL316407:JW1114-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1114-MONOMER BioCyc EcoCyc:EG11430-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11430-MONOMER BioCyc MetaCyc:EG11430-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11430-MONOMER DIP DIP-11535N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11535N DOI 10.1016/j.jmb.2014.02.008 http://dx.doi.org/10.1016/j.jmb.2014.02.008 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature13263 http://dx.doi.org/10.1038/nature13263 DOI 10.1038/nchembio.1093 http://dx.doi.org/10.1038/nchembio.1093 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.14.11.47 {ECO:0000269|PubMed:23103944} http://www.genome.jp/dbget-bin/www_bget?EC:1.14.11.47 {ECO:0000269|PubMed:23103944} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D90393 http://www.ebi.ac.uk/ena/data/view/D90393 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.14.11.47 {ECO:0000269|PubMed:23103944} http://enzyme.expasy.org/EC/1.14.11.47 {ECO:0000269|PubMed:23103944} EchoBASE EB1400 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1400 EcoGene EG11430 http://www.ecogene.org/geneInfo.php?eg_id=EG11430 EnsemblBacteria AAC74212 http://www.ensemblgenomes.org/id/AAC74212 EnsemblBacteria AAC74212 http://www.ensemblgenomes.org/id/AAC74212 EnsemblBacteria BAA35950 http://www.ensemblgenomes.org/id/BAA35950 EnsemblBacteria BAA35950 http://www.ensemblgenomes.org/id/BAA35950 EnsemblBacteria BAA35950 http://www.ensemblgenomes.org/id/BAA35950 EnsemblBacteria b1128 http://www.ensemblgenomes.org/id/b1128 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008198 GO_function GO:0016706 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016706 GO_process GO:0030961 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030961 GO_process GO:0042254 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042254 GO_process GO:0043687 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043687 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0042254 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042254 GeneID 945391 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945391 HOGENOM HOG000261963 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261963&db=HOGENOM6 InParanoid P27431 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P27431 IntAct P27431 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P27431* IntEnz 1.14.11.47 {ECO:0000269|PubMed:23103944} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.14.11.47 {ECO:0000269|PubMed:23103944} InterPro IPR003347 http://www.ebi.ac.uk/interpro/entry/IPR003347 KEGG_Gene ecj:JW1114 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1114 KEGG_Gene eco:b1128 http://www.genome.jp/dbget-bin/www_bget?eco:b1128 OMA FTPIIDV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FTPIIDV PDB 4CCL http://www.ebi.ac.uk/pdbe-srv/view/entry/4CCL PDB 4LIT http://www.ebi.ac.uk/pdbe-srv/view/entry/4LIT PDB 4LIU http://www.ebi.ac.uk/pdbe-srv/view/entry/4LIU PDB 4LIV http://www.ebi.ac.uk/pdbe-srv/view/entry/4LIV PDB 4NUB http://www.ebi.ac.uk/pdbe-srv/view/entry/4NUB PDBsum 4CCL http://www.ebi.ac.uk/pdbsum/4CCL PDBsum 4LIT http://www.ebi.ac.uk/pdbsum/4LIT PDBsum 4LIU http://www.ebi.ac.uk/pdbsum/4LIU PDBsum 4LIV http://www.ebi.ac.uk/pdbsum/4LIV PDBsum 4NUB http://www.ebi.ac.uk/pdbsum/4NUB PROSITE PS51184 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51184 PSORT swissprot:ROXA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ROXA_ECOLI PSORT-B swissprot:ROXA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ROXA_ECOLI PSORT2 swissprot:ROXA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ROXA_ECOLI Pfam PF08007 http://pfam.xfam.org/family/PF08007 Phobius swissprot:ROXA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ROXA_ECOLI PhylomeDB P27431 http://phylomedb.org/?seqid=P27431 ProteinModelPortal P27431 http://www.proteinmodelportal.org/query/uniprot/P27431 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1729240 http://www.ncbi.nlm.nih.gov/pubmed/1729240 PubMed 23103944 http://www.ncbi.nlm.nih.gov/pubmed/23103944 PubMed 24530688 http://www.ncbi.nlm.nih.gov/pubmed/24530688 PubMed 24814345 http://www.ncbi.nlm.nih.gov/pubmed/24814345 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415646 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415646 RefSeq WP_000456506 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000456506 SMART SM00558 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00558 SMR P27431 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P27431 STRING 511145.b1128 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1128&targetmode=cogs UniProtKB ROXA_ECOLI http://www.uniprot.org/uniprot/ROXA_ECOLI UniProtKB-AC P27431 http://www.uniprot.org/uniprot/P27431 charge swissprot:ROXA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ROXA_ECOLI eggNOG COG2850 http://eggnogapi.embl.de/nog_data/html/tree/COG2850 eggNOG ENOG4105EZE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EZE epestfind swissprot:ROXA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ROXA_ECOLI garnier swissprot:ROXA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ROXA_ECOLI helixturnhelix swissprot:ROXA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ROXA_ECOLI hmoment swissprot:ROXA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ROXA_ECOLI iep swissprot:ROXA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ROXA_ECOLI inforesidue swissprot:ROXA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ROXA_ECOLI octanol swissprot:ROXA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ROXA_ECOLI pepcoil swissprot:ROXA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ROXA_ECOLI pepdigest swissprot:ROXA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ROXA_ECOLI pepinfo swissprot:ROXA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ROXA_ECOLI pepnet swissprot:ROXA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ROXA_ECOLI pepstats swissprot:ROXA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ROXA_ECOLI pepwheel swissprot:ROXA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ROXA_ECOLI pepwindow swissprot:ROXA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ROXA_ECOLI sigcleave swissprot:ROXA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ROXA_ECOLI ## Database ID URL or Descriptions # BioGrid 4263378 975 # EcoGene EG12915 yhfT # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR019733 Uncharacterised_YhfT # Organism YHFT_ECOLI Escherichia coli (strain K12) # PATRIC 32122186 VBIEscCol129921_3470 # PIR D65132 D65132 # Pfam PF10797 YhfT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHFT_ECOLI Uncharacterized protein YhfT # RefSeq NP_417836 NC_000913.3 # RefSeq WP_000366857 NZ_CP014272.1 # SUBCELLULAR LOCATION YHFT_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # TCDB 9.B.118.1 the 11 or 12 tms yhft (yhft) family # eggNOG ENOG4106M0N Bacteria # eggNOG ENOG410XRS1 LUCA BLAST swissprot:YHFT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHFT_ECOLI BioCyc ECOL316407:JW3340-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3340-MONOMER BioCyc EcoCyc:G7729-MONOMER http://biocyc.org/getid?id=EcoCyc:G7729-MONOMER DIP DIP-12329N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12329N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2751 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2751 EcoGene EG12915 http://www.ecogene.org/geneInfo.php?eg_id=EG12915 EnsemblBacteria AAC76402 http://www.ensemblgenomes.org/id/AAC76402 EnsemblBacteria AAC76402 http://www.ensemblgenomes.org/id/AAC76402 EnsemblBacteria BAE77914 http://www.ensemblgenomes.org/id/BAE77914 EnsemblBacteria BAE77914 http://www.ensemblgenomes.org/id/BAE77914 EnsemblBacteria BAE77914 http://www.ensemblgenomes.org/id/BAE77914 EnsemblBacteria b3377 http://www.ensemblgenomes.org/id/b3377 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 947883 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947883 HOGENOM HOG000125453 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125453&db=HOGENOM6 IntAct P45546 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45546* InterPro IPR019733 http://www.ebi.ac.uk/interpro/entry/IPR019733 KEGG_Gene ecj:JW3340 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3340 KEGG_Gene eco:b3377 http://www.genome.jp/dbget-bin/www_bget?eco:b3377 MINT MINT-1320428 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1320428 OMA MGEHIRT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MGEHIRT PSORT swissprot:YHFT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHFT_ECOLI PSORT-B swissprot:YHFT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHFT_ECOLI PSORT2 swissprot:YHFT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHFT_ECOLI Pfam PF10797 http://pfam.xfam.org/family/PF10797 Phobius swissprot:YHFT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHFT_ECOLI ProteinModelPortal P45546 http://www.proteinmodelportal.org/query/uniprot/P45546 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417836 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417836 RefSeq WP_000366857 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000366857 STRING 511145.b3377 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3377&targetmode=cogs TCDB 9.B.118.1 http://www.tcdb.org/search/result.php?tc=9.B.118.1 UniProtKB YHFT_ECOLI http://www.uniprot.org/uniprot/YHFT_ECOLI UniProtKB-AC P45546 http://www.uniprot.org/uniprot/P45546 charge swissprot:YHFT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHFT_ECOLI eggNOG ENOG4106M0N http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106M0N eggNOG ENOG410XRS1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRS1 epestfind swissprot:YHFT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHFT_ECOLI garnier swissprot:YHFT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHFT_ECOLI helixturnhelix swissprot:YHFT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHFT_ECOLI hmoment swissprot:YHFT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHFT_ECOLI iep swissprot:YHFT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHFT_ECOLI inforesidue swissprot:YHFT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHFT_ECOLI octanol swissprot:YHFT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHFT_ECOLI pepcoil swissprot:YHFT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHFT_ECOLI pepdigest swissprot:YHFT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHFT_ECOLI pepinfo swissprot:YHFT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHFT_ECOLI pepnet swissprot:YHFT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHFT_ECOLI pepstats swissprot:YHFT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHFT_ECOLI pepwheel swissprot:YHFT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHFT_ECOLI pepwindow swissprot:YHFT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHFT_ECOLI sigcleave swissprot:YHFT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHFT_ECOLI ## Database ID URL or Descriptions # BioGrid 4259491 8 # EcoGene EG11173 yhaB # InterPro IPR016420 UCP004546 # Organism YHAB_ECOLI Escherichia coli (strain K12) # PATRIC 32121656 VBIEscCol129921_3214 # PIR E65101 Q3ECTR # PIRSF PIRSF004546 UCP004546 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHAB_ECOLI Uncharacterized protein YhaB # RefSeq NP_417590 NC_000913.3 # RefSeq WP_000675733 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA57924.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; BLAST swissprot:YHAB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHAB_ECOLI BioCyc ECOL316407:JW3091-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3091-MONOMER BioCyc EcoCyc:EG11173-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11173-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/17.10.3994 http://dx.doi.org/10.1093/nar/17.10.3994 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X14430 http://www.ebi.ac.uk/ena/data/view/X14430 EMBL X16445 http://www.ebi.ac.uk/ena/data/view/X16445 EchoBASE EB1160 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1160 EcoGene EG11173 http://www.ecogene.org/geneInfo.php?eg_id=EG11173 EnsemblBacteria AAC76155 http://www.ensemblgenomes.org/id/AAC76155 EnsemblBacteria AAC76155 http://www.ensemblgenomes.org/id/AAC76155 EnsemblBacteria BAE77169 http://www.ensemblgenomes.org/id/BAE77169 EnsemblBacteria BAE77169 http://www.ensemblgenomes.org/id/BAE77169 EnsemblBacteria BAE77169 http://www.ensemblgenomes.org/id/BAE77169 EnsemblBacteria b3120 http://www.ensemblgenomes.org/id/b3120 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947705 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947705 HOGENOM HOG000009597 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009597&db=HOGENOM6 InterPro IPR016420 http://www.ebi.ac.uk/interpro/entry/IPR016420 KEGG_Gene ecj:JW3091 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3091 KEGG_Gene eco:b3120 http://www.genome.jp/dbget-bin/www_bget?eco:b3120 OMA EQCICSA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EQCICSA PSORT swissprot:YHAB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHAB_ECOLI PSORT-B swissprot:YHAB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHAB_ECOLI PSORT2 swissprot:YHAB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHAB_ECOLI Phobius swissprot:YHAB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHAB_ECOLI ProteinModelPortal P11865 http://www.proteinmodelportal.org/query/uniprot/P11865 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2660107 http://www.ncbi.nlm.nih.gov/pubmed/2660107 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417590 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417590 RefSeq WP_000675733 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000675733 STRING 511145.b3120 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3120&targetmode=cogs UniProtKB YHAB_ECOLI http://www.uniprot.org/uniprot/YHAB_ECOLI UniProtKB-AC P11865 http://www.uniprot.org/uniprot/P11865 charge swissprot:YHAB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHAB_ECOLI epestfind swissprot:YHAB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHAB_ECOLI garnier swissprot:YHAB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHAB_ECOLI helixturnhelix swissprot:YHAB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHAB_ECOLI hmoment swissprot:YHAB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHAB_ECOLI iep swissprot:YHAB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHAB_ECOLI inforesidue swissprot:YHAB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHAB_ECOLI octanol swissprot:YHAB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHAB_ECOLI pepcoil swissprot:YHAB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHAB_ECOLI pepdigest swissprot:YHAB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHAB_ECOLI pepinfo swissprot:YHAB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHAB_ECOLI pepnet swissprot:YHAB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHAB_ECOLI pepstats swissprot:YHAB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHAB_ECOLI pepwheel swissprot:YHAB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHAB_ECOLI pepwindow swissprot:YHAB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHAB_ECOLI sigcleave swissprot:YHAB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHAB_ECOLI ## Database ID URL or Descriptions # BioGrid 4259812 7 # EcoGene EG11327 codB # FUNCTION CODB_ECOLI Required for cytosine transport into the cell. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015209 cytosine transmembrane transporter activity; IEA:InterPro. # GO_process GO:0015992 proton transport; IEA:GOC. # GO_process GO:0019858 cytosine metabolic process; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # InterPro IPR001248 Pur-cyt_permease # InterPro IPR030191 CodB # Organism CODB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30569 PTHR30569 # PATRIC 32115803 VBIEscCol129921_0343 # PIR S22661 S22661 # Pfam PF02133 Transp_cyt_pur # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CODB_ECOLI Cytosine permease # RefSeq NP_414870 NC_000913.3 # RefSeq WP_000076233 NZ_LN832404.1 # SIMILARITY Belongs to the purine-cytosine permease (2.A.39) family. {ECO 0000305}. # SUBCELLULAR LOCATION CODB_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.39.1:the nucleobase cation symporter-1 (ncs1) family # eggNOG COG1457 LUCA # eggNOG ENOG4105DQW Bacteria BLAST swissprot:CODB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CODB_ECOLI BioCyc ECOL316407:JW0327-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0327-MONOMER BioCyc EcoCyc:CODB-MONOMER http://biocyc.org/getid?id=EcoCyc:CODB-MONOMER BioCyc MetaCyc:CODB-MONOMER http://biocyc.org/getid?id=MetaCyc:CODB-MONOMER COG COG1457 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1457 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1992.tb00854.x http://dx.doi.org/10.1111/j.1365-2958.1992.tb00854.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EMBL X63656 http://www.ebi.ac.uk/ena/data/view/X63656 EchoBASE EB1303 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1303 EcoGene EG11327 http://www.ecogene.org/geneInfo.php?eg_id=EG11327 EnsemblBacteria AAC73439 http://www.ensemblgenomes.org/id/AAC73439 EnsemblBacteria AAC73439 http://www.ensemblgenomes.org/id/AAC73439 EnsemblBacteria BAE76118 http://www.ensemblgenomes.org/id/BAE76118 EnsemblBacteria BAE76118 http://www.ensemblgenomes.org/id/BAE76118 EnsemblBacteria BAE76118 http://www.ensemblgenomes.org/id/BAE76118 EnsemblBacteria b0336 http://www.ensemblgenomes.org/id/b0336 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015209 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015209 GO_process GO:0015992 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015992 GO_process GO:0019858 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019858 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 944994 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944994 HOGENOM HOG000117411 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117411&db=HOGENOM6 InParanoid P0AA82 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AA82 InterPro IPR001248 http://www.ebi.ac.uk/interpro/entry/IPR001248 InterPro IPR030191 http://www.ebi.ac.uk/interpro/entry/IPR030191 KEGG_Gene ecj:JW0327 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0327 KEGG_Gene eco:b0336 http://www.genome.jp/dbget-bin/www_bget?eco:b0336 KEGG_Orthology KO:K10974 http://www.genome.jp/dbget-bin/www_bget?KO:K10974 OMA AWGTATI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AWGTATI PANTHER PTHR30569 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30569 PSORT swissprot:CODB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CODB_ECOLI PSORT-B swissprot:CODB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CODB_ECOLI PSORT2 swissprot:CODB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CODB_ECOLI Pfam PF02133 http://pfam.xfam.org/family/PF02133 Phobius swissprot:CODB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CODB_ECOLI PhylomeDB P0AA82 http://phylomedb.org/?seqid=P0AA82 ProteinModelPortal P0AA82 http://www.proteinmodelportal.org/query/uniprot/P0AA82 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 1640834 http://www.ncbi.nlm.nih.gov/pubmed/1640834 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414870 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414870 RefSeq WP_000076233 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000076233 STRING 511145.b0336 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0336&targetmode=cogs STRING COG1457 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1457&targetmode=cogs TCDB 2.A.39.1 http://www.tcdb.org/search/result.php?tc=2.A.39.1 UniProtKB CODB_ECOLI http://www.uniprot.org/uniprot/CODB_ECOLI UniProtKB-AC P0AA82 http://www.uniprot.org/uniprot/P0AA82 charge swissprot:CODB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CODB_ECOLI eggNOG COG1457 http://eggnogapi.embl.de/nog_data/html/tree/COG1457 eggNOG ENOG4105DQW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DQW epestfind swissprot:CODB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CODB_ECOLI garnier swissprot:CODB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CODB_ECOLI helixturnhelix swissprot:CODB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CODB_ECOLI hmoment swissprot:CODB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CODB_ECOLI iep swissprot:CODB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CODB_ECOLI inforesidue swissprot:CODB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CODB_ECOLI octanol swissprot:CODB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CODB_ECOLI pepcoil swissprot:CODB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CODB_ECOLI pepdigest swissprot:CODB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CODB_ECOLI pepinfo swissprot:CODB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CODB_ECOLI pepnet swissprot:CODB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CODB_ECOLI pepstats swissprot:CODB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CODB_ECOLI pepwheel swissprot:CODB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CODB_ECOLI pepwindow swissprot:CODB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CODB_ECOLI sigcleave swissprot:CODB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CODB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260713 7 # EcoGene EG13643 ybdJ # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR010590 DUF1158 # Organism YBDJ_ECOLI Escherichia coli (strain K12) # PATRIC 32116328 VBIEscCol129921_0604 # PIR B64791 B64791 # Pfam PF06643 DUF1158 # ProDom PD027061 DUF1158 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBDJ_ECOLI Uncharacterized protein YbdJ # RefSeq NP_415112 NC_000913.3 # RefSeq WP_000682509 NZ_LN832404.1 # SUBCELLULAR LOCATION YBDJ_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # eggNOG ENOG4105WQ6 Bacteria # eggNOG ENOG41122VD LUCA BLAST swissprot:YBDJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBDJ_ECOLI BioCyc ECOL316407:JW0569-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0569-MONOMER BioCyc EcoCyc:G6325-MONOMER http://biocyc.org/getid?id=EcoCyc:G6325-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB3407 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3407 EcoGene EG13643 http://www.ecogene.org/geneInfo.php?eg_id=EG13643 EnsemblBacteria AAC73681 http://www.ensemblgenomes.org/id/AAC73681 EnsemblBacteria AAC73681 http://www.ensemblgenomes.org/id/AAC73681 EnsemblBacteria BAA35220 http://www.ensemblgenomes.org/id/BAA35220 EnsemblBacteria BAA35220 http://www.ensemblgenomes.org/id/BAA35220 EnsemblBacteria BAA35220 http://www.ensemblgenomes.org/id/BAA35220 EnsemblBacteria b0580 http://www.ensemblgenomes.org/id/b0580 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 947183 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947183 HOGENOM HOG000267877 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267877&db=HOGENOM6 InterPro IPR010590 http://www.ebi.ac.uk/interpro/entry/IPR010590 KEGG_Gene ecj:JW0569 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0569 KEGG_Gene eco:b0580 http://www.genome.jp/dbget-bin/www_bget?eco:b0580 OMA FVWRRWF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FVWRRWF PSORT swissprot:YBDJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBDJ_ECOLI PSORT-B swissprot:YBDJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBDJ_ECOLI PSORT2 swissprot:YBDJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBDJ_ECOLI Pfam PF06643 http://pfam.xfam.org/family/PF06643 Phobius swissprot:YBDJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBDJ_ECOLI ProteinModelPortal P77506 http://www.proteinmodelportal.org/query/uniprot/P77506 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415112 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415112 RefSeq WP_000682509 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000682509 STRING 511145.b0580 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0580&targetmode=cogs UniProtKB YBDJ_ECOLI http://www.uniprot.org/uniprot/YBDJ_ECOLI UniProtKB-AC P77506 http://www.uniprot.org/uniprot/P77506 charge swissprot:YBDJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBDJ_ECOLI eggNOG ENOG4105WQ6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105WQ6 eggNOG ENOG41122VD http://eggnogapi.embl.de/nog_data/html/tree/ENOG41122VD epestfind swissprot:YBDJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBDJ_ECOLI garnier swissprot:YBDJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBDJ_ECOLI helixturnhelix swissprot:YBDJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBDJ_ECOLI hmoment swissprot:YBDJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBDJ_ECOLI iep swissprot:YBDJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBDJ_ECOLI inforesidue swissprot:YBDJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBDJ_ECOLI octanol swissprot:YBDJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBDJ_ECOLI pepcoil swissprot:YBDJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBDJ_ECOLI pepdigest swissprot:YBDJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBDJ_ECOLI pepinfo swissprot:YBDJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBDJ_ECOLI pepnet swissprot:YBDJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBDJ_ECOLI pepstats swissprot:YBDJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBDJ_ECOLI pepwheel swissprot:YBDJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBDJ_ECOLI pepwindow swissprot:YBDJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBDJ_ECOLI sigcleave swissprot:YBDJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBDJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4262445 10 # EcoGene EG10977 sspA # FUNCTION SSPA_ECOLI Forms an equimolar complex with the RNA polymerase holoenzyme (RNAP) but not with the core enzyme. It is synthesized predominantly when cells are exposed to amino acid starvation, at which time it accounts for over 50% of the total protein synthesized. It is involved in the transition from P1 early to P1 late gene expression. Rnk and SspA can functionally replace P.aeruginosa alginate regulatory gene algR2. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004364 glutathione transferase activity; IBA:GO_Central. # GO_process GO:0006749 glutathione metabolic process; IBA:GO_Central. # GO_process GO:0042594 response to starvation; IEP:EcoCyc. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.20.1050.10 -; 1. # Gene3D 3.40.30.10 -; 1. # INDUCTION SSPA_ECOLI By amino acid starvation. # INTERACTION SSPA_ECOLI P54745 mngA; NbExp=4; IntAct=EBI-558482, EBI-558542; # IntAct P0ACA3 13 # InterPro IPR004045 Glutathione_S-Trfase_N # InterPro IPR004046 GST_C # InterPro IPR010987 Glutathione-S-Trfase_C-like # InterPro IPR012336 Thioredoxin-like_fold # KEGG_Brite ko03021 Transcription machinery # Organism SSPA_ECOLI Escherichia coli (strain K12) # PATRIC 32121882 VBIEscCol129921_3325 # PIR A26422 RGECSS # PROSITE PS50404 GST_NTER # PROSITE PS50405 GST_CTER # Pfam PF00043 GST_C # Pfam PF02798 GST_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SSPA_ECOLI Stringent starvation protein A # RefSeq NP_417696 NC_000913.3 # RefSeq WP_000257293 NZ_LN832404.1 # SIMILARITY Belongs to the GST superfamily. HSP26 family. {ECO 0000305}. # SIMILARITY Contains 1 GST C-terminal domain. {ECO 0000305}. # SIMILARITY Contains 1 GST N-terminal domain. {ECO 0000305}. # SUPFAM SSF47616 SSF47616 # SUPFAM SSF52833 SSF52833 # TCDB 1.A.12.3 the intracellular chloride channel (clic) family # eggNOG COG0625 LUCA # eggNOG ENOG4107MKT Bacteria BLAST swissprot:SSPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SSPA_ECOLI BioCyc ECOL316407:JW3198-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3198-MONOMER BioCyc EcoCyc:EG10977-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10977-MONOMER COG COG0625 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0625 DIP DIP-48104N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48104N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/15.3.1153 http://dx.doi.org/10.1093/nar/15.3.1153 DOI 10.1111/j.1365-2958.1994.tb00381.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb00381.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X05088 http://www.ebi.ac.uk/ena/data/view/X05088 EchoBASE EB0970 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0970 EcoGene EG10977 http://www.ecogene.org/geneInfo.php?eg_id=EG10977 EnsemblBacteria AAC76261 http://www.ensemblgenomes.org/id/AAC76261 EnsemblBacteria AAC76261 http://www.ensemblgenomes.org/id/AAC76261 EnsemblBacteria BAE77272 http://www.ensemblgenomes.org/id/BAE77272 EnsemblBacteria BAE77272 http://www.ensemblgenomes.org/id/BAE77272 EnsemblBacteria BAE77272 http://www.ensemblgenomes.org/id/BAE77272 EnsemblBacteria b3229 http://www.ensemblgenomes.org/id/b3229 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004364 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004364 GO_process GO:0006749 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006749 GO_process GO:0042594 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042594 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016765 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.20.1050.10 http://www.cathdb.info/version/latest/superfamily/1.20.1050.10 Gene3D 3.40.30.10 http://www.cathdb.info/version/latest/superfamily/3.40.30.10 GeneID 944744 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944744 HOGENOM HOG000255228 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000255228&db=HOGENOM6 InParanoid P0ACA3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACA3 IntAct P0ACA3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACA3* InterPro IPR004045 http://www.ebi.ac.uk/interpro/entry/IPR004045 InterPro IPR004046 http://www.ebi.ac.uk/interpro/entry/IPR004046 InterPro IPR010987 http://www.ebi.ac.uk/interpro/entry/IPR010987 InterPro IPR012336 http://www.ebi.ac.uk/interpro/entry/IPR012336 KEGG_Brite ko03021 http://www.genome.jp/dbget-bin/www_bget?ko03021 KEGG_Gene ecj:JW3198 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3198 KEGG_Gene eco:b3229 http://www.genome.jp/dbget-bin/www_bget?eco:b3229 KEGG_Orthology KO:K03599 http://www.genome.jp/dbget-bin/www_bget?KO:K03599 MINT MINT-1228576 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1228576 OMA MHRIQRD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MHRIQRD PROSITE PS50404 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50404 PROSITE PS50405 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50405 PSORT swissprot:SSPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SSPA_ECOLI PSORT-B swissprot:SSPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SSPA_ECOLI PSORT2 swissprot:SSPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SSPA_ECOLI Pfam PF00043 http://pfam.xfam.org/family/PF00043 Pfam PF02798 http://pfam.xfam.org/family/PF02798 Phobius swissprot:SSPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SSPA_ECOLI PhylomeDB P0ACA3 http://phylomedb.org/?seqid=P0ACA3 ProteinModelPortal P0ACA3 http://www.proteinmodelportal.org/query/uniprot/P0ACA3 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3029697 http://www.ncbi.nlm.nih.gov/pubmed/3029697 PubMed 8022275 http://www.ncbi.nlm.nih.gov/pubmed/8022275 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_417696 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417696 RefSeq WP_000257293 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000257293 SMR P0ACA3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACA3 STRING 511145.b3229 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3229&targetmode=cogs STRING COG0625 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0625&targetmode=cogs SUPFAM SSF47616 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47616 SUPFAM SSF52833 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52833 SWISS-2DPAGE P0ACA3 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0ACA3 TCDB 1.A.12.3 http://www.tcdb.org/search/result.php?tc=1.A.12.3 UniProtKB SSPA_ECOLI http://www.uniprot.org/uniprot/SSPA_ECOLI UniProtKB-AC P0ACA3 http://www.uniprot.org/uniprot/P0ACA3 charge swissprot:SSPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SSPA_ECOLI eggNOG COG0625 http://eggnogapi.embl.de/nog_data/html/tree/COG0625 eggNOG ENOG4107MKT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107MKT epestfind swissprot:SSPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SSPA_ECOLI garnier swissprot:SSPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SSPA_ECOLI helixturnhelix swissprot:SSPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SSPA_ECOLI hmoment swissprot:SSPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SSPA_ECOLI iep swissprot:SSPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SSPA_ECOLI inforesidue swissprot:SSPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SSPA_ECOLI octanol swissprot:SSPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SSPA_ECOLI pepcoil swissprot:SSPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SSPA_ECOLI pepdigest swissprot:SSPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SSPA_ECOLI pepinfo swissprot:SSPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SSPA_ECOLI pepnet swissprot:SSPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SSPA_ECOLI pepstats swissprot:SSPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SSPA_ECOLI pepwheel swissprot:SSPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SSPA_ECOLI pepwindow swissprot:SSPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SSPA_ECOLI sigcleave swissprot:SSPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SSPA_ECOLI ## Database ID URL or Descriptions # BioGrid 4263342 13 # EcoGene EG14231 yqiJ # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006950 response to stress # InterPro IPR010840 DUF1449 # Organism YQIJ_ECOLI Escherichia coli (strain K12) # PATRIC 32121512 VBIEscCol129921_3143 # PIR H65092 H65092 # Pfam PF07290 DUF1449 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQIJ_ECOLI Inner membrane protein YqiJ # RefSeq NP_417522 NC_000913.3 # RefSeq WP_000599926 NZ_LN832404.1 # SUBCELLULAR LOCATION YQIJ_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG ENOG4105PV3 Bacteria # eggNOG ENOG4111XIY LUCA BLAST swissprot:YQIJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQIJ_ECOLI BioCyc ECOL316407:JW3022-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3022-MONOMER BioCyc EcoCyc:G7588-MONOMER http://biocyc.org/getid?id=EcoCyc:G7588-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3982 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3982 EcoGene EG14231 http://www.ecogene.org/geneInfo.php?eg_id=EG14231 EnsemblBacteria AAC76086 http://www.ensemblgenomes.org/id/AAC76086 EnsemblBacteria AAC76086 http://www.ensemblgenomes.org/id/AAC76086 EnsemblBacteria BAE77102 http://www.ensemblgenomes.org/id/BAE77102 EnsemblBacteria BAE77102 http://www.ensemblgenomes.org/id/BAE77102 EnsemblBacteria BAE77102 http://www.ensemblgenomes.org/id/BAE77102 EnsemblBacteria b3050 http://www.ensemblgenomes.org/id/b3050 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 947530 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947530 HOGENOM HOG000125093 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125093&db=HOGENOM6 InParanoid P76657 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76657 InterPro IPR010840 http://www.ebi.ac.uk/interpro/entry/IPR010840 KEGG_Gene ecj:JW3022 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3022 KEGG_Gene eco:b3050 http://www.genome.jp/dbget-bin/www_bget?eco:b3050 OMA HDETYAV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HDETYAV PSORT swissprot:YQIJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQIJ_ECOLI PSORT-B swissprot:YQIJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQIJ_ECOLI PSORT2 swissprot:YQIJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQIJ_ECOLI Pfam PF07290 http://pfam.xfam.org/family/PF07290 Phobius swissprot:YQIJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQIJ_ECOLI ProteinModelPortal P76657 http://www.proteinmodelportal.org/query/uniprot/P76657 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417522 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417522 RefSeq WP_000599926 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000599926 STRING 511145.b3050 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3050&targetmode=cogs UniProtKB YQIJ_ECOLI http://www.uniprot.org/uniprot/YQIJ_ECOLI UniProtKB-AC P76657 http://www.uniprot.org/uniprot/P76657 charge swissprot:YQIJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQIJ_ECOLI eggNOG ENOG4105PV3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105PV3 eggNOG ENOG4111XIY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111XIY epestfind swissprot:YQIJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQIJ_ECOLI garnier swissprot:YQIJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQIJ_ECOLI helixturnhelix swissprot:YQIJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQIJ_ECOLI hmoment swissprot:YQIJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQIJ_ECOLI iep swissprot:YQIJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQIJ_ECOLI inforesidue swissprot:YQIJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQIJ_ECOLI octanol swissprot:YQIJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQIJ_ECOLI pepcoil swissprot:YQIJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQIJ_ECOLI pepdigest swissprot:YQIJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQIJ_ECOLI pepinfo swissprot:YQIJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQIJ_ECOLI pepnet swissprot:YQIJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQIJ_ECOLI pepstats swissprot:YQIJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQIJ_ECOLI pepwheel swissprot:YQIJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQIJ_ECOLI pepwindow swissprot:YQIJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQIJ_ECOLI sigcleave swissprot:YQIJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQIJ_ECOLI ## Database ID URL or Descriptions # AltName EPTA_ECOLI Polymyxin resistance protein PmrC # BioGrid 4263082 117 # EcoGene EG11613 eptA # FUNCTION EPTA_ECOLI Catalyzes the addition of a phosphoethanolamine moiety to the lipid A. The phosphoethanolamine modification is required for resistance to polymyxin (By similarity). {ECO 0000250}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0008484 sulfuric ester hydrolase activity; IEA:InterPro. # GO_function GO:0016776 phosphotransferase activity, phosphate group as acceptor; TAS:EcoCyc. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; TAS:EcoCyc. # GO_process GO:0009244 lipopolysaccharide core region biosynthetic process; IBA:GO_Central. # GO_process GO:0009245 lipid A biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.720.10 -; 1. # INDUCTION The eptA-basRS operon is positively autoregulated by BasR under high iron or aluminum concentration conditions. {ECO 0000250}. # IntAct P30845 2 # InterPro IPR000917 Sulfatase_N # InterPro IPR012549 DUF1705 # InterPro IPR017849 Alkaline_Pase-like_a/b/a # InterPro IPR017850 Alkaline_phosphatase_core # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # Organism EPTA_ECOLI Escherichia coli (strain K12) # PATRIC 32123793 VBIEscCol129921_4245 # Pfam PF00884 Sulfatase # Pfam PF08019 DUF1705 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EPTA_ECOLI Phosphoethanolamine transferase EptA # RefSeq NP_418538 NC_000913.3 # RefSeq WP_000919792 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97013.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the phosphoethanolamine transferase family. EptA subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION EPTA_ECOLI Cell inner membrane {ECO 0000269|PubMed 16079137}; Multi-pass membrane protein {ECO 0000269|PubMed 16079137}. # SUBUNIT Has been isolated as a 91 kDa complex containing ZipA- EptA and an unidentified 24 kDa protein. {ECO:0000269|PubMed 16079137}. # SUPFAM SSF53649 SSF53649 # eggNOG COG2194 LUCA # eggNOG ENOG4105DIJ Bacteria BLAST swissprot:EPTA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EPTA_ECOLI BioCyc ECOL316407:JW5730-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5730-MONOMER BioCyc EcoCyc:EG11613-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11613-MONOMER BioCyc MetaCyc:EG11613-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11613-MONOMER COG COG2194 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2194 DIP DIP-12561N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12561N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.-.- http://www.genome.jp/dbget-bin/www_bget?EC:2.7.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D14055 http://www.ebi.ac.uk/ena/data/view/D14055 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 2.7.-.- http://enzyme.expasy.org/EC/2.7.-.- EchoBASE EB1570 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1570 EcoGene EG11613 http://www.ecogene.org/geneInfo.php?eg_id=EG11613 EnsemblBacteria AAC77075 http://www.ensemblgenomes.org/id/AAC77075 EnsemblBacteria AAC77075 http://www.ensemblgenomes.org/id/AAC77075 EnsemblBacteria BAE78116 http://www.ensemblgenomes.org/id/BAE78116 EnsemblBacteria BAE78116 http://www.ensemblgenomes.org/id/BAE78116 EnsemblBacteria BAE78116 http://www.ensemblgenomes.org/id/BAE78116 EnsemblBacteria b4114 http://www.ensemblgenomes.org/id/b4114 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008484 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008484 GO_function GO:0016776 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016776 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GO_process GO:0009244 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009244 GO_process GO:0009245 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009245 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.720.10 http://www.cathdb.info/version/latest/superfamily/3.40.720.10 GeneID 948629 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948629 HOGENOM HOG000275171 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275171&db=HOGENOM6 InParanoid P30845 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30845 IntAct P30845 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P30845* IntEnz 2.7 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7 InterPro IPR000917 http://www.ebi.ac.uk/interpro/entry/IPR000917 InterPro IPR012549 http://www.ebi.ac.uk/interpro/entry/IPR012549 InterPro IPR017849 http://www.ebi.ac.uk/interpro/entry/IPR017849 InterPro IPR017850 http://www.ebi.ac.uk/interpro/entry/IPR017850 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Gene ecj:JW5730 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5730 KEGG_Gene eco:b4114 http://www.genome.jp/dbget-bin/www_bget?eco:b4114 KEGG_Orthology KO:K03760 http://www.genome.jp/dbget-bin/www_bget?KO:K03760 MINT MINT-1218890 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1218890 OMA LFKEKHS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LFKEKHS PSORT swissprot:EPTA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EPTA_ECOLI PSORT-B swissprot:EPTA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EPTA_ECOLI PSORT2 swissprot:EPTA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EPTA_ECOLI Pfam PF00884 http://pfam.xfam.org/family/PF00884 Pfam PF08019 http://pfam.xfam.org/family/PF08019 Phobius swissprot:EPTA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EPTA_ECOLI PhylomeDB P30845 http://phylomedb.org/?seqid=P30845 ProteinModelPortal P30845 http://www.proteinmodelportal.org/query/uniprot/P30845 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8282725 http://www.ncbi.nlm.nih.gov/pubmed/8282725 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418538 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418538 RefSeq WP_000919792 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000919792 SMR P30845 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P30845 STRING 511145.b4114 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4114&targetmode=cogs STRING COG2194 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2194&targetmode=cogs SUPFAM SSF53649 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53649 UniProtKB EPTA_ECOLI http://www.uniprot.org/uniprot/EPTA_ECOLI UniProtKB-AC P30845 http://www.uniprot.org/uniprot/P30845 charge swissprot:EPTA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EPTA_ECOLI eggNOG COG2194 http://eggnogapi.embl.de/nog_data/html/tree/COG2194 eggNOG ENOG4105DIJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DIJ epestfind swissprot:EPTA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EPTA_ECOLI garnier swissprot:EPTA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EPTA_ECOLI helixturnhelix swissprot:EPTA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EPTA_ECOLI hmoment swissprot:EPTA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EPTA_ECOLI iep swissprot:EPTA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EPTA_ECOLI inforesidue swissprot:EPTA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EPTA_ECOLI octanol swissprot:EPTA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EPTA_ECOLI pepcoil swissprot:EPTA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EPTA_ECOLI pepdigest swissprot:EPTA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EPTA_ECOLI pepinfo swissprot:EPTA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EPTA_ECOLI pepnet swissprot:EPTA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EPTA_ECOLI pepstats swissprot:EPTA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EPTA_ECOLI pepwheel swissprot:EPTA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EPTA_ECOLI pepwindow swissprot:EPTA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EPTA_ECOLI sigcleave swissprot:EPTA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EPTA_ECOLI ## Database ID URL or Descriptions # BRENDA 3.6.3.B1 2026 # BioGrid 4261117 215 # COFACTOR SECA_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 10213615}; Note=Binds 1 zinc ion per subunit. Zinc is required for binding of the SecB chaperone to the extreme C-terminus of SecA. {ECO 0000269|PubMed 10213615}; # DISRUPTION PHENOTYPE Essential. Leads to loss of translocation of lipoproteins Lpp and BRP. {ECO:0000269|PubMed 15140892}. # EcoGene EG10936 secA # FUNCTION SECA_ECOLI Required for protein export, interacts with the SecYEG preprotein conducting channel. SecA has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein- SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. {ECO 0000269|PubMed 15140892}. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005886 plasma membrane; IDA:EcoliWiki. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0031522 cell envelope Sec protein transport complex; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IBA:GO_Central. # GO_function GO:0015462 ATPase-coupled protein transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006605 protein targeting; IMP:EcoliWiki. # GO_process GO:0015031 protein transport; IMP:EcoliWiki. # GO_process GO:0017038 protein import; IEA:InterPro. # GO_process GO:0043952 protein transport by the Sec complex; IDA:EcoCyc. # GO_process GO:0061077 chaperone-mediated protein folding; IDA:EcoCyc. # GO_process GO:0065002 intracellular protein transmembrane transport; IMP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0008565 protein transporter activity # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006457 protein folding # GOslim_process GO:0006605 protein targeting # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # Gene3D 1.10.3060.10 -; 1. # Gene3D 3.40.50.300 -; 3. # Gene3D 3.90.1440.10 -; 1. # HAMAP MF_01382 SecA # INDUCTION SECA_ECOLI Repressed under conditions of excess protein secretion capacity and derepressed when protein secretion becomes limiting. This is regulated by SecM. # INTERACTION SECA_ECOLI Self; NbExp=3; IntAct=EBI-543213, EBI-543213; P02943 lamB; NbExp=3; IntAct=EBI-543213, EBI-371309; P0AG86 secB; NbExp=4; IntAct=EBI-543213, EBI-555877; P0AG99 secG; NbExp=2; IntAct=EBI-543213, EBI-6404248; P0AGA2 secY; NbExp=4; IntAct=EBI-543213, EBI-761422; P0A8Z3 ybgC; NbExp=2; IntAct=EBI-543213, EBI-543276; # IntAct P10408 77 # InterPro IPR000185 SecA # InterPro IPR004027 SEC_C_motif # InterPro IPR011115 SecA_DEAD # InterPro IPR011116 SecA_Wing/Scaffold # InterPro IPR011130 SecA_preprotein_X-link_dom # InterPro IPR014018 SecA_motor_DEAD # InterPro IPR020937 SecA_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02044 M00335 Sec (secretion) system # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko03060 Protein export # KEGG_Pathway ko03070 Bacterial secretion system # Organism SECA_ECOLI Escherichia coli (strain K12) # PATRIC 32115301 VBIEscCol129921_0102 # PDB 1TM6 NMR; -; A=880-901 # PDB 2FSF X-ray; 2.00 A; A/B=9-861 # PDB 2FSG X-ray; 2.20 A; A/B=9-861 # PDB 2FSH X-ray; 2.00 A; A/B=9-861 # PDB 2FSI X-ray; 2.11 A; A/B=9-861 # PDB 2VDA NMR; -; A=9-836 # PDB 3BXZ X-ray; 3.00 A; A/B=6-609 # PIR B64732 BVECCA # PRINTS PR00906 SECA # PROSITE PS01312 SECA # PROSITE PS51196 SECA_MOTOR_DEAD # Pfam PF01043 SecA_PP_bind # Pfam PF02810 SEC-C # Pfam PF07516 SecA_SW # Pfam PF07517 SecA_DEAD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SECA_ECOLI Protein translocase subunit SecA # RefSeq NP_414640 NC_000913.3 # RefSeq WP_000905789 NZ_LN832404.1 # SIMILARITY Belongs to the SecA family. {ECO 0000305}. # SMART SM00957 SecA_DEAD # SMART SM00958 SecA_PP_bind # SUBCELLULAR LOCATION SECA_ECOLI Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Distribution is 50-50. # SUBUNIT SECA_ECOLI Monomer and homodimer; probably dimeric in the cytoplasm. It is not yet clear whether the form that functions in protein insertion is monomeric or dimeric. Part of the essential protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC. Makes direct contact with SecY. # SUPFAM SSF52540 SSF52540; 3 # SUPFAM SSF81767 SSF81767 # SUPFAM SSF81886 SSF81886; 2 # TCDB 3.A.5.1 the general secretory pathway (sec) family # TIGRFAMs TIGR00963 secA # eggNOG COG0653 LUCA # eggNOG ENOG4105CI6 Bacteria BLAST swissprot:SECA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SECA_ECOLI BioCyc ECOL316407:JW0096-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0096-MONOMER BioCyc EcoCyc:SECA http://biocyc.org/getid?id=EcoCyc:SECA COG COG0653 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0653 DIP DIP-10840N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10840N DOI 10.1016/S0022-2836(03)00840-4 http://dx.doi.org/10.1016/S0022-2836(03)00840-4 DOI 10.1016/j.bbapap.2004.08.012 http://dx.doi.org/10.1016/j.bbapap.2004.08.012 DOI 10.1016/j.cell.2007.02.036 http://dx.doi.org/10.1016/j.cell.2007.02.036 DOI 10.1016/j.jmb.2006.12.049 http://dx.doi.org/10.1016/j.jmb.2006.12.049 DOI 10.1016/j.mib.2004.01.001 http://dx.doi.org/10.1016/j.mib.2004.01.001 DOI 10.1021/bi982818r http://dx.doi.org/10.1021/bi982818r DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nrmicro1771 http://dx.doi.org/10.1038/nrmicro1771 DOI 10.1038/sj.emboj.7601721 http://dx.doi.org/10.1038/sj.emboj.7601721 DOI 10.1074/jbc.M205992200 http://dx.doi.org/10.1074/jbc.M205992200 DOI 10.1074/jbc.M403229200 http://dx.doi.org/10.1074/jbc.M403229200 DOI 10.1093/emboj/cdf471 http://dx.doi.org/10.1093/emboj/cdf471 DOI 10.1093/emboj/cdg418 http://dx.doi.org/10.1093/emboj/cdg418 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M19211 http://www.ebi.ac.uk/ena/data/view/M19211 EMBL M20791 http://www.ebi.ac.uk/ena/data/view/M20791 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X55034 http://www.ebi.ac.uk/ena/data/view/X55034 EchoBASE EB0929 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0929 EcoGene EG10936 http://www.ecogene.org/geneInfo.php?eg_id=EG10936 EnsemblBacteria AAC73209 http://www.ensemblgenomes.org/id/AAC73209 EnsemblBacteria AAC73209 http://www.ensemblgenomes.org/id/AAC73209 EnsemblBacteria BAB96666 http://www.ensemblgenomes.org/id/BAB96666 EnsemblBacteria BAB96666 http://www.ensemblgenomes.org/id/BAB96666 EnsemblBacteria BAB96666 http://www.ensemblgenomes.org/id/BAB96666 EnsemblBacteria b0098 http://www.ensemblgenomes.org/id/b0098 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0031522 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031522 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0015462 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015462 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006605 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006605 GO_process GO:0015031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031 GO_process GO:0017038 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017038 GO_process GO:0043952 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043952 GO_process GO:0061077 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061077 GO_process GO:0065002 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0065002 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GOslim_process GO:0006605 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006605 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 1.10.3060.10 http://www.cathdb.info/version/latest/superfamily/1.10.3060.10 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 Gene3D 3.90.1440.10 http://www.cathdb.info/version/latest/superfamily/3.90.1440.10 GeneID 944821 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944821 HAMAP MF_01382 http://hamap.expasy.org/unirule/MF_01382 HOGENOM HOG000218168 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218168&db=HOGENOM6 InParanoid P10408 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P10408 IntAct P10408 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P10408* InterPro IPR000185 http://www.ebi.ac.uk/interpro/entry/IPR000185 InterPro IPR004027 http://www.ebi.ac.uk/interpro/entry/IPR004027 InterPro IPR011115 http://www.ebi.ac.uk/interpro/entry/IPR011115 InterPro IPR011116 http://www.ebi.ac.uk/interpro/entry/IPR011116 InterPro IPR011130 http://www.ebi.ac.uk/interpro/entry/IPR011130 InterPro IPR014018 http://www.ebi.ac.uk/interpro/entry/IPR014018 InterPro IPR020937 http://www.ebi.ac.uk/interpro/entry/IPR020937 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW0096 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0096 KEGG_Gene eco:b0098 http://www.genome.jp/dbget-bin/www_bget?eco:b0098 KEGG_Orthology KO:K03070 http://www.genome.jp/dbget-bin/www_bget?KO:K03070 KEGG_Pathway ko03060 http://www.genome.jp/kegg-bin/show_pathway?ko03060 KEGG_Pathway ko03070 http://www.genome.jp/kegg-bin/show_pathway?ko03070 MINT MINT-1224866 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1224866 OMA IATERHE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IATERHE PDB 1TM6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1TM6 PDB 2FSF http://www.ebi.ac.uk/pdbe-srv/view/entry/2FSF PDB 2FSG http://www.ebi.ac.uk/pdbe-srv/view/entry/2FSG PDB 2FSH http://www.ebi.ac.uk/pdbe-srv/view/entry/2FSH PDB 2FSI http://www.ebi.ac.uk/pdbe-srv/view/entry/2FSI PDB 2VDA http://www.ebi.ac.uk/pdbe-srv/view/entry/2VDA PDB 3BXZ http://www.ebi.ac.uk/pdbe-srv/view/entry/3BXZ PDBsum 1TM6 http://www.ebi.ac.uk/pdbsum/1TM6 PDBsum 2FSF http://www.ebi.ac.uk/pdbsum/2FSF PDBsum 2FSG http://www.ebi.ac.uk/pdbsum/2FSG PDBsum 2FSH http://www.ebi.ac.uk/pdbsum/2FSH PDBsum 2FSI http://www.ebi.ac.uk/pdbsum/2FSI PDBsum 2VDA http://www.ebi.ac.uk/pdbsum/2VDA PDBsum 3BXZ http://www.ebi.ac.uk/pdbsum/3BXZ PRINTS PR00906 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00906 PROSITE PS01312 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01312 PROSITE PS51196 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51196 PSORT swissprot:SECA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SECA_ECOLI PSORT-B swissprot:SECA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SECA_ECOLI PSORT2 swissprot:SECA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SECA_ECOLI Pfam PF01043 http://pfam.xfam.org/family/PF01043 Pfam PF02810 http://pfam.xfam.org/family/PF02810 Pfam PF07516 http://pfam.xfam.org/family/PF07516 Pfam PF07517 http://pfam.xfam.org/family/PF07517 Phobius swissprot:SECA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SECA_ECOLI PhylomeDB P10408 http://phylomedb.org/?seqid=P10408 ProteinModelPortal P10408 http://www.proteinmodelportal.org/query/uniprot/P10408 PubMed 10213615 http://www.ncbi.nlm.nih.gov/pubmed/10213615 PubMed 12198149 http://www.ncbi.nlm.nih.gov/pubmed/12198149 PubMed 12403785 http://www.ncbi.nlm.nih.gov/pubmed/12403785 PubMed 12941690 http://www.ncbi.nlm.nih.gov/pubmed/12941690 PubMed 12946344 http://www.ncbi.nlm.nih.gov/pubmed/12946344 PubMed 15063851 http://www.ncbi.nlm.nih.gov/pubmed/15063851 PubMed 15140892 http://www.ncbi.nlm.nih.gov/pubmed/15140892 PubMed 15488768 http://www.ncbi.nlm.nih.gov/pubmed/15488768 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17229438 http://www.ncbi.nlm.nih.gov/pubmed/17229438 PubMed 17418789 http://www.ncbi.nlm.nih.gov/pubmed/17418789 PubMed 17525736 http://www.ncbi.nlm.nih.gov/pubmed/17525736 PubMed 17938627 http://www.ncbi.nlm.nih.gov/pubmed/17938627 PubMed 2542029 http://www.ncbi.nlm.nih.gov/pubmed/2542029 PubMed 2824434 http://www.ncbi.nlm.nih.gov/pubmed/2824434 PubMed 2841285 http://www.ncbi.nlm.nih.gov/pubmed/2841285 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414640 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414640 RefSeq WP_000905789 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000905789 SMART SM00957 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00957 SMART SM00958 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00958 SMR P10408 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P10408 STRING 511145.b0098 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0098&targetmode=cogs STRING COG0653 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0653&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SUPFAM SSF81767 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81767 SUPFAM SSF81886 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81886 TCDB 3.A.5.1 http://www.tcdb.org/search/result.php?tc=3.A.5.1 TIGRFAMs TIGR00963 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00963 UniProtKB SECA_ECOLI http://www.uniprot.org/uniprot/SECA_ECOLI UniProtKB-AC P10408 http://www.uniprot.org/uniprot/P10408 charge swissprot:SECA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SECA_ECOLI eggNOG COG0653 http://eggnogapi.embl.de/nog_data/html/tree/COG0653 eggNOG ENOG4105CI6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CI6 epestfind swissprot:SECA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SECA_ECOLI garnier swissprot:SECA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SECA_ECOLI helixturnhelix swissprot:SECA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SECA_ECOLI hmoment swissprot:SECA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SECA_ECOLI iep swissprot:SECA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SECA_ECOLI inforesidue swissprot:SECA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SECA_ECOLI octanol swissprot:SECA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SECA_ECOLI pepcoil swissprot:SECA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SECA_ECOLI pepdigest swissprot:SECA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SECA_ECOLI pepinfo swissprot:SECA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SECA_ECOLI pepnet swissprot:SECA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SECA_ECOLI pepstats swissprot:SECA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SECA_ECOLI pepwheel swissprot:SECA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SECA_ECOLI pepwindow swissprot:SECA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SECA_ECOLI sigcleave swissprot:SECA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SECA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261980 12 # EcoGene EG12464 dcuR # FUNCTION DCUR_ECOLI Member of the two-component regulatory system DcuR/DcuS. Involved in the C4-dicarboxylate-stimulated regulation of the genes encoding the anaerobic fumarate respiratory system (frdABCD; nuoAN; dcuB; dcuC; sdhCDAB; etc.). Weakly regulates the aerobic C4-dicarboxylate transporter dctA. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0001071 nucleic acid binding transcription factor activity; IEA:InterPro. # GO_function GO:0003677 DNA binding; IDA:EcoliWiki. # GO_process GO:0000160 phosphorelay signal transduction system; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEP:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0009605 response to external stimulus; IEA:InterPro. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.60 -; 1. # IntAct P0AD01 4 # InterPro IPR001789 Sig_transdc_resp-reg_receiver # InterPro IPR009057 Homeodomain-like # InterPro IPR011006 CheY-like_superfamily # InterPro IPR024187 Sig_transdc_resp-reg_cit/mal # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02022 M00488 DcuS-DcuR (aerobic C4-dicarboxylate metabolism) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # Organism DCUR_ECOLI Escherichia coli (strain K12) # PATRIC 32123813 VBIEscCol129921_4255 # PIR C65222 C65222 # PIRSF PIRSF006171 RR_citrat_malat # PROSITE PS50110 RESPONSE_REGULATORY # PTM DCUR_ECOLI Phosphorylated and activated by DcuS. # Pfam PF00072 Response_reg # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DCUR_ECOLI Transcriptional regulatory protein DcuR # RefSeq NP_418548 NC_000913.3 # RefSeq WP_000611288 NZ_LN832404.1 # SIMILARITY Contains 1 response regulatory domain. {ECO:0000255|PROSITE-ProRule PRU00169}. # SMART SM00448 REC # SUBCELLULAR LOCATION DCUR_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF52172 SSF52172 # eggNOG COG4565 LUCA # eggNOG ENOG4108MRH Bacteria BLAST swissprot:DCUR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DCUR_ECOLI BioCyc ECOL316407:JW4085-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4085-MONOMER BioCyc EcoCyc:DCUR-MONOMER http://biocyc.org/getid?id=EcoCyc:DCUR-MONOMER COG COG4565 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4565 DIP DIP-48032N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48032N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M204482200 http://dx.doi.org/10.1074/jbc.M204482200 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2357 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2357 EcoGene EG12464 http://www.ecogene.org/geneInfo.php?eg_id=EG12464 EnsemblBacteria AAC77085 http://www.ensemblgenomes.org/id/AAC77085 EnsemblBacteria AAC77085 http://www.ensemblgenomes.org/id/AAC77085 EnsemblBacteria BAE78126 http://www.ensemblgenomes.org/id/BAE78126 EnsemblBacteria BAE78126 http://www.ensemblgenomes.org/id/BAE78126 EnsemblBacteria BAE78126 http://www.ensemblgenomes.org/id/BAE78126 EnsemblBacteria b4124 http://www.ensemblgenomes.org/id/b4124 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0009605 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009605 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 GeneID 948640 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948640 HOGENOM HOG000034816 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000034816&db=HOGENOM6 InParanoid P0AD01 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AD01 IntAct P0AD01 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AD01* InterPro IPR001789 http://www.ebi.ac.uk/interpro/entry/IPR001789 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR011006 http://www.ebi.ac.uk/interpro/entry/IPR011006 InterPro IPR024187 http://www.ebi.ac.uk/interpro/entry/IPR024187 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW4085 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4085 KEGG_Gene eco:b4124 http://www.genome.jp/dbget-bin/www_bget?eco:b4124 KEGG_Orthology KO:K07703 http://www.genome.jp/dbget-bin/www_bget?KO:K07703 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA ICQWIDA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ICQWIDA PROSITE PS50110 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50110 PSORT swissprot:DCUR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DCUR_ECOLI PSORT-B swissprot:DCUR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DCUR_ECOLI PSORT2 swissprot:DCUR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DCUR_ECOLI Pfam PF00072 http://pfam.xfam.org/family/PF00072 Phobius swissprot:DCUR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DCUR_ECOLI PhylomeDB P0AD01 http://phylomedb.org/?seqid=P0AD01 ProteinModelPortal P0AD01 http://www.proteinmodelportal.org/query/uniprot/P0AD01 PubMed 12167640 http://www.ncbi.nlm.nih.gov/pubmed/12167640 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9765574 http://www.ncbi.nlm.nih.gov/pubmed/9765574 RefSeq NP_418548 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418548 RefSeq WP_000611288 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000611288 SMART SM00448 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00448 SMR P0AD01 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AD01 STRING 511145.b4124 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4124&targetmode=cogs STRING COG4565 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4565&targetmode=cogs SUPFAM SSF52172 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52172 UniProtKB DCUR_ECOLI http://www.uniprot.org/uniprot/DCUR_ECOLI UniProtKB-AC P0AD01 http://www.uniprot.org/uniprot/P0AD01 charge swissprot:DCUR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DCUR_ECOLI eggNOG COG4565 http://eggnogapi.embl.de/nog_data/html/tree/COG4565 eggNOG ENOG4108MRH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MRH epestfind swissprot:DCUR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DCUR_ECOLI garnier swissprot:DCUR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DCUR_ECOLI helixturnhelix swissprot:DCUR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DCUR_ECOLI hmoment swissprot:DCUR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DCUR_ECOLI iep swissprot:DCUR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DCUR_ECOLI inforesidue swissprot:DCUR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DCUR_ECOLI octanol swissprot:DCUR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DCUR_ECOLI pepcoil swissprot:DCUR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DCUR_ECOLI pepdigest swissprot:DCUR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DCUR_ECOLI pepinfo swissprot:DCUR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DCUR_ECOLI pepnet swissprot:DCUR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DCUR_ECOLI pepstats swissprot:DCUR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DCUR_ECOLI pepwheel swissprot:DCUR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DCUR_ECOLI pepwindow swissprot:DCUR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DCUR_ECOLI sigcleave swissprot:DCUR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DCUR_ECOLI ## Database ID URL or Descriptions # AltName Leucyl-tRNA synthetase {ECO:0000255|HAMAP-Rule MF_00049} # BRENDA 6.1.1 2026 # BioGrid 4263356 16 # CATALYTIC ACTIVITY ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). {ECO:0000255|HAMAP- Rule MF_00049}. # EcoGene EG10532 leuS # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0002161 aminoacyl-tRNA editing activity; IEA:InterPro. # GO_function GO:0004823 leucine-tRNA ligase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006429 leucyl-tRNA aminoacylation; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0006520 cellular amino acid metabolic process # Gene3D 1.10.730.10 -; 1. # Gene3D 3.40.50.620 -; 3. # Gene3D 3.90.740.10 -; 1. # HAMAP MF_00049_B Leu_tRNA_synth_B # IntAct P07813 21 # InterPro IPR001412 aa-tRNA-synth_I_CS # InterPro IPR002300 aa-tRNA-synth_Ia # InterPro IPR002302 Leu-tRNA-ligase # InterPro IPR009008 Val/Leu/Ile-tRNA-synth_edit # InterPro IPR009080 tRNAsynth_Ia_anticodon-bd # InterPro IPR013155 M/V/L/I-tRNA-synth_anticd-bd # InterPro IPR014729 Rossmann-like_a/b/a_fold # InterPro IPR025709 Leu_tRNA-synth_edit # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01007 Amino acid related enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # KEGG_Pathway ko00970 Aminoacyl-tRNA biosynthesis # Organism SYL_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11946:SF7 PTHR11946:SF7; 3 # PATRIC 32116467 VBIEscCol129921_0673 # PDB 2AJG X-ray; 2.00 A; A/B=228-413 # PDB 2AJH X-ray; 2.40 A; A/B=228-413 # PDB 2AJI X-ray; 3.20 A; A/B=228-413 # PDB 3ZGZ X-ray; 2.40 A; A/D=1-860 # PDB 3ZJT X-ray; 2.20 A; A=1-860 # PDB 3ZJU X-ray; 2.40 A; A=1-860 # PDB 3ZJV X-ray; 2.31 A; A=1-860 # PDB 4AQ7 X-ray; 2.50 A; A/D=1-860 # PDB 4ARC X-ray; 2.00 A; A=1-860 # PDB 4ARI X-ray; 2.08 A; A=1-860 # PDB 4AS1 X-ray; 2.02 A; A=1-860 # PDB 4CQN X-ray; 2.50 A; A/D=1-860 # PIR H64798 SYECL # PRINTS PR00985 TRNASYNTHLEU # PROSITE PS00178 AA_TRNA_LIGASE_I # Pfam PF00133 tRNA-synt_1; 3 # Pfam PF08264 Anticodon_1 # Pfam PF13603 tRNA-synt_1_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Leucine--tRNA ligase {ECO:0000255|HAMAP-Rule MF_00049} # RefSeq NP_415175 NC_000913.3 # RefSeq WP_001340834 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40843.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the class-I aminoacyl-tRNA synthetase family. {ECO:0000255|HAMAP-Rule MF_00049}. # SUBCELLULAR LOCATION SYL_ECOLI Cytoplasm. # SUBUNIT SYL_ECOLI Monomer. # SUPFAM SSF47323 SSF47323 # SUPFAM SSF50677 SSF50677 # TIGRFAMs TIGR00396 leuS_bact # eggNOG COG0495 LUCA # eggNOG ENOG4105C8T Bacteria BLAST swissprot:SYL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SYL_ECOLI BioCyc ECOL316407:JW0637-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0637-MONOMER BioCyc EcoCyc:LEUS-MONOMER http://biocyc.org/getid?id=EcoCyc:LEUS-MONOMER BioCyc MetaCyc:LEUS-MONOMER http://biocyc.org/getid?id=MetaCyc:LEUS-MONOMER COG COG0495 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0495 DIP DIP-10095N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10095N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/15.24.10199 http://dx.doi.org/10.1093/nar/15.24.10199 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.1.1.4 {ECO:0000255|HAMAP-Rule:MF_00049} http://www.genome.jp/dbget-bin/www_bget?EC:6.1.1.4 {ECO:0000255|HAMAP-Rule:MF_00049} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EMBL X06331 http://www.ebi.ac.uk/ena/data/view/X06331 ENZYME 6.1.1.4 {ECO:0000255|HAMAP-Rule:MF_00049} http://enzyme.expasy.org/EC/6.1.1.4 {ECO:0000255|HAMAP-Rule:MF_00049} EchoBASE EB0527 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0527 EcoGene EG10532 http://www.ecogene.org/geneInfo.php?eg_id=EG10532 EnsemblBacteria AAC73743 http://www.ensemblgenomes.org/id/AAC73743 EnsemblBacteria AAC73743 http://www.ensemblgenomes.org/id/AAC73743 EnsemblBacteria BAA35289 http://www.ensemblgenomes.org/id/BAA35289 EnsemblBacteria BAA35289 http://www.ensemblgenomes.org/id/BAA35289 EnsemblBacteria BAA35289 http://www.ensemblgenomes.org/id/BAA35289 EnsemblBacteria b0642 http://www.ensemblgenomes.org/id/b0642 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0002161 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002161 GO_function GO:0004823 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004823 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006429 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006429 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 Gene3D 1.10.730.10 http://www.cathdb.info/version/latest/superfamily/1.10.730.10 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 Gene3D 3.90.740.10 http://www.cathdb.info/version/latest/superfamily/3.90.740.10 GeneID 947497 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947497 HAMAP MF_00049_B http://hamap.expasy.org/unirule/MF_00049_B HOGENOM HOG000200747 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000200747&db=HOGENOM6 InParanoid P07813 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P07813 IntAct P07813 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P07813* IntEnz 6.1.1.4 {ECO:0000255|HAMAP-Rule:MF_00049} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.1.1.4 {ECO:0000255|HAMAP-Rule:MF_00049} InterPro IPR001412 http://www.ebi.ac.uk/interpro/entry/IPR001412 InterPro IPR002300 http://www.ebi.ac.uk/interpro/entry/IPR002300 InterPro IPR002302 http://www.ebi.ac.uk/interpro/entry/IPR002302 InterPro IPR009008 http://www.ebi.ac.uk/interpro/entry/IPR009008 InterPro IPR009080 http://www.ebi.ac.uk/interpro/entry/IPR009080 InterPro IPR013155 http://www.ebi.ac.uk/interpro/entry/IPR013155 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 InterPro IPR025709 http://www.ebi.ac.uk/interpro/entry/IPR025709 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW0637 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0637 KEGG_Gene eco:b0642 http://www.genome.jp/dbget-bin/www_bget?eco:b0642 KEGG_Orthology KO:K01869 http://www.genome.jp/dbget-bin/www_bget?KO:K01869 KEGG_Pathway ko00970 http://www.genome.jp/kegg-bin/show_pathway?ko00970 KEGG_Reaction rn:R03657 http://www.genome.jp/dbget-bin/www_bget?rn:R03657 MINT MINT-1226410 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1226410 OMA HRFIKRL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HRFIKRL PANTHER PTHR11946:SF7 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11946:SF7 PDB 2AJG http://www.ebi.ac.uk/pdbe-srv/view/entry/2AJG PDB 2AJH http://www.ebi.ac.uk/pdbe-srv/view/entry/2AJH PDB 2AJI http://www.ebi.ac.uk/pdbe-srv/view/entry/2AJI PDB 3ZGZ http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZGZ PDB 3ZJT http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZJT PDB 3ZJU http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZJU PDB 3ZJV http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZJV PDB 4AQ7 http://www.ebi.ac.uk/pdbe-srv/view/entry/4AQ7 PDB 4ARC http://www.ebi.ac.uk/pdbe-srv/view/entry/4ARC PDB 4ARI http://www.ebi.ac.uk/pdbe-srv/view/entry/4ARI PDB 4AS1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4AS1 PDB 4CQN http://www.ebi.ac.uk/pdbe-srv/view/entry/4CQN PDBsum 2AJG http://www.ebi.ac.uk/pdbsum/2AJG PDBsum 2AJH http://www.ebi.ac.uk/pdbsum/2AJH PDBsum 2AJI http://www.ebi.ac.uk/pdbsum/2AJI PDBsum 3ZGZ http://www.ebi.ac.uk/pdbsum/3ZGZ PDBsum 3ZJT http://www.ebi.ac.uk/pdbsum/3ZJT PDBsum 3ZJU http://www.ebi.ac.uk/pdbsum/3ZJU PDBsum 3ZJV http://www.ebi.ac.uk/pdbsum/3ZJV PDBsum 4AQ7 http://www.ebi.ac.uk/pdbsum/4AQ7 PDBsum 4ARC http://www.ebi.ac.uk/pdbsum/4ARC PDBsum 4ARI http://www.ebi.ac.uk/pdbsum/4ARI PDBsum 4AS1 http://www.ebi.ac.uk/pdbsum/4AS1 PDBsum 4CQN http://www.ebi.ac.uk/pdbsum/4CQN PRINTS PR00985 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00985 PROSITE PS00178 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00178 PSORT swissprot:SYL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SYL_ECOLI PSORT-B swissprot:SYL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SYL_ECOLI PSORT2 swissprot:SYL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SYL_ECOLI Pfam PF00133 http://pfam.xfam.org/family/PF00133 Pfam PF08264 http://pfam.xfam.org/family/PF08264 Pfam PF13603 http://pfam.xfam.org/family/PF13603 Phobius swissprot:SYL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SYL_ECOLI PhylomeDB P07813 http://phylomedb.org/?seqid=P07813 ProteinModelPortal P07813 http://www.proteinmodelportal.org/query/uniprot/P07813 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3320963 http://www.ncbi.nlm.nih.gov/pubmed/3320963 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_415175 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415175 RefSeq WP_001340834 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001340834 SMR P07813 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P07813 STRING 511145.b0642 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0642&targetmode=cogs STRING COG0495 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0495&targetmode=cogs SUPFAM SSF47323 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47323 SUPFAM SSF50677 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50677 SWISS-2DPAGE P07813 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P07813 TIGRFAMs TIGR00396 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00396 UniProtKB SYL_ECOLI http://www.uniprot.org/uniprot/SYL_ECOLI UniProtKB-AC P07813 http://www.uniprot.org/uniprot/P07813 charge swissprot:SYL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SYL_ECOLI eggNOG COG0495 http://eggnogapi.embl.de/nog_data/html/tree/COG0495 eggNOG ENOG4105C8T http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C8T epestfind swissprot:SYL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SYL_ECOLI garnier swissprot:SYL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SYL_ECOLI helixturnhelix swissprot:SYL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SYL_ECOLI hmoment swissprot:SYL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SYL_ECOLI iep swissprot:SYL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SYL_ECOLI inforesidue swissprot:SYL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SYL_ECOLI octanol swissprot:SYL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SYL_ECOLI pepcoil swissprot:SYL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SYL_ECOLI pepdigest swissprot:SYL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SYL_ECOLI pepinfo swissprot:SYL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SYL_ECOLI pepnet swissprot:SYL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SYL_ECOLI pepstats swissprot:SYL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SYL_ECOLI pepwheel swissprot:SYL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SYL_ECOLI pepwindow swissprot:SYL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SYL_ECOLI sigcleave swissprot:SYL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SYL_ECOLI ## Database ID URL or Descriptions # CATALYTIC ACTIVITY HEMG_ECOLI Protoporphyrinogen IX + 3 menaquinone = protoporphyrin IX + 3 menaquinol. # EcoGene EG11485 hemG # FUNCTION HEMG_ECOLI Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX using menaquinone as electron acceptor. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004729 oxygen-dependent protoporphyrinogen oxidase activity; IDA:EcoCyc. # GO_function GO:0009055 electron carrier activity; IEA:InterPro. # GO_function GO:0010181 FMN binding; IDA:EcoCyc. # GO_function GO:0070819 menaquinone-dependent protoporphyrinogen oxidase activity; IDA:EcoCyc. # GO_process GO:0006779 porphyrin-containing compound biosynthetic process; IMP:EcoliWiki. # GO_process GO:0006782 protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0006783 heme biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.360 -; 2. # IntAct P0ACB4 18 # InterPro IPR001226 Flavodoxin_CS # InterPro IPR008254 Flavodoxin/NO_synth # InterPro IPR026816 Flavodoxin_dom # InterPro IPR029039 Flavoprotein-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00860 Porphyrin and chlorophyll metabolism # Organism HEMG_ECOLI Escherichia coli (strain K12) # PATHWAY Porphyrin-containing compound metabolism; protoporphyrin- IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX step 1/1. # PATRIC 32123197 VBIEscCol129921_3964 # PIR JC2513 JC2513 # PROSITE PS00201 FLAVODOXIN # PROSITE PS50902 FLAVODOXIN_LIKE # Pfam PF12724 Flavodoxin_5 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HEMG_ECOLI Protoporphyrinogen IX dehydrogenase [menaquinone] # RefSeq NP_418292 NC_000913.3 # RefSeq WP_000853959 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=X54687; Type=Frameshift; Positions=159; Evidence={ECO 0000305}; # SIMILARITY Contains 1 flavodoxin-like domain. {ECO:0000255|PROSITE-ProRule PRU00088}. # SUBUNIT HEMG_ECOLI Belongs to a multi-protein complex. # SUPFAM SSF52218 SSF52218 # UniPathway UPA00251 UER00324 # eggNOG COG4635 LUCA # eggNOG ENOG4108RR8 Bacteria BLAST swissprot:HEMG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HEMG_ECOLI BioCyc ECOL316407:JW3827-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3827-MONOMER BioCyc EcoCyc:PROTOPORGENOXI-MONOMER http://biocyc.org/getid?id=EcoCyc:PROTOPORGENOXI-MONOMER BioCyc MetaCyc:PROTOPORGENOXI-MONOMER http://biocyc.org/getid?id=MetaCyc:PROTOPORGENOXI-MONOMER COG COG0716 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0716 DIP DIP-35890N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35890N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/2.1.1 http://dx.doi.org/10.1093/dnares/2.1.1 DOI 10.1093/nar/18.21.6439 http://dx.doi.org/10.1093/nar/18.21.6439 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.3.5.3 http://www.genome.jp/dbget-bin/www_bget?EC:1.3.5.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X54687 http://www.ebi.ac.uk/ena/data/view/X54687 EMBL X68660 http://www.ebi.ac.uk/ena/data/view/X68660 ENZYME 1.3.5.3 http://enzyme.expasy.org/EC/1.3.5.3 EchoBASE EB1448 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1448 EcoGene EG11485 http://www.ecogene.org/geneInfo.php?eg_id=EG11485 EnsemblBacteria AAC76853 http://www.ensemblgenomes.org/id/AAC76853 EnsemblBacteria AAC76853 http://www.ensemblgenomes.org/id/AAC76853 EnsemblBacteria BAE77453 http://www.ensemblgenomes.org/id/BAE77453 EnsemblBacteria BAE77453 http://www.ensemblgenomes.org/id/BAE77453 EnsemblBacteria BAE77453 http://www.ensemblgenomes.org/id/BAE77453 EnsemblBacteria b3850 http://www.ensemblgenomes.org/id/b3850 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004729 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004729 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0010181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010181 GO_function GO:0070819 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070819 GO_process GO:0006779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006779 GO_process GO:0006782 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006782 GO_process GO:0006783 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006783 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.360 http://www.cathdb.info/version/latest/superfamily/3.40.50.360 GeneID 948331 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948331 HOGENOM HOG000251295 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000251295&db=HOGENOM6 InParanoid P0ACB4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACB4 IntAct P0ACB4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACB4* IntEnz 1.3.5.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.3.5.3 InterPro IPR001226 http://www.ebi.ac.uk/interpro/entry/IPR001226 InterPro IPR008254 http://www.ebi.ac.uk/interpro/entry/IPR008254 InterPro IPR026816 http://www.ebi.ac.uk/interpro/entry/IPR026816 InterPro IPR029039 http://www.ebi.ac.uk/interpro/entry/IPR029039 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3827 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3827 KEGG_Gene eco:b3850 http://www.genome.jp/dbget-bin/www_bget?eco:b3850 KEGG_Orthology KO:K00230 http://www.genome.jp/dbget-bin/www_bget?KO:K00230 KEGG_Pathway ko00860 http://www.genome.jp/kegg-bin/show_pathway?ko00860 KEGG_Reaction rn:R09489 http://www.genome.jp/dbget-bin/www_bget?rn:R09489 OMA KGTLECD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KGTLECD PROSITE PS00201 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00201 PROSITE PS50902 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50902 PSORT swissprot:HEMG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HEMG_ECOLI PSORT-B swissprot:HEMG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HEMG_ECOLI PSORT2 swissprot:HEMG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HEMG_ECOLI Pfam PF12724 http://pfam.xfam.org/family/PF12724 Phobius swissprot:HEMG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HEMG_ECOLI PhylomeDB P0ACB4 http://phylomedb.org/?seqid=P0ACB4 ProteinModelPortal P0ACB4 http://www.proteinmodelportal.org/query/uniprot/P0ACB4 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2243799 http://www.ncbi.nlm.nih.gov/pubmed/2243799 PubMed 7788523 http://www.ncbi.nlm.nih.gov/pubmed/7788523 PubMed 7916647 http://www.ncbi.nlm.nih.gov/pubmed/7916647 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418292 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418292 RefSeq WP_000853959 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000853959 STRING 511145.b3850 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3850&targetmode=cogs STRING COG0716 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0716&targetmode=cogs SUPFAM SSF52218 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52218 UniProtKB HEMG_ECOLI http://www.uniprot.org/uniprot/HEMG_ECOLI UniProtKB-AC P0ACB4 http://www.uniprot.org/uniprot/P0ACB4 charge swissprot:HEMG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HEMG_ECOLI eggNOG COG4635 http://eggnogapi.embl.de/nog_data/html/tree/COG4635 eggNOG ENOG4108RR8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108RR8 epestfind swissprot:HEMG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HEMG_ECOLI garnier swissprot:HEMG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HEMG_ECOLI helixturnhelix swissprot:HEMG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HEMG_ECOLI hmoment swissprot:HEMG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HEMG_ECOLI iep swissprot:HEMG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HEMG_ECOLI inforesidue swissprot:HEMG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HEMG_ECOLI octanol swissprot:HEMG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HEMG_ECOLI pepcoil swissprot:HEMG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HEMG_ECOLI pepdigest swissprot:HEMG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HEMG_ECOLI pepinfo swissprot:HEMG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HEMG_ECOLI pepnet swissprot:HEMG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HEMG_ECOLI pepstats swissprot:HEMG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HEMG_ECOLI pepwheel swissprot:HEMG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HEMG_ECOLI pepwindow swissprot:HEMG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HEMG_ECOLI sigcleave swissprot:HEMG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HEMG_ECOLI ## Database ID URL or Descriptions # BioGrid 4261135 13 # EcoGene EG13285 ygaM # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005886 plasma membrane # INDUCTION Maximally expressed between 6 and 12 hours of growth, in early stationary phase. {ECO:0000269|PubMed 22661687}. # IntAct P0ADQ7 4 # InterPro IPR010279 DUF883_ElaB # Organism YGAM_ECOLI Escherichia coli (strain K12) # PATRIC 32120734 VBIEscCol129921_2764 # PIR A65047 A65047 # Pfam PF05957 DUF883 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGAM_ECOLI Uncharacterized protein YgaM # RefSeq NP_417158 NC_000913.3 # RefSeq WP_001295174 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA16537.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA56183.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=CAA56183.1; Type=Frameshift; Positions=80; Evidence={ECO:0000305}; # SIMILARITY Belongs to the ElaB/YgaM/YqjD family. {ECO 0000305}. # SUBCELLULAR LOCATION YGAM_ECOLI Cell inner membrane {ECO 0000305}; Single- pass membrane protein {ECO 0000305}. # SUBUNIT YGAM_ECOLI Upon overexpression binds to ribosomes. # eggNOG COG4575 LUCA # eggNOG ENOG4108ZQZ Bacteria BLAST swissprot:YGAM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGAM_ECOLI BioCyc ECOL316407:JW2647-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2647-MONOMER BioCyc EcoCyc:B0899-MONOMER http://biocyc.org/getid?id=EcoCyc:B0899-MONOMER DIP DIP-48124N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48124N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1996.424950.x http://dx.doi.org/10.1046/j.1365-2958.1996.424950.x DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00396-12 http://dx.doi.org/10.1128/JB.00396-12 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X79787 http://www.ebi.ac.uk/ena/data/view/X79787 EchoBASE EB3070 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3070 EcoGene EG13285 http://www.ecogene.org/geneInfo.php?eg_id=EG13285 EnsemblBacteria AAC75719 http://www.ensemblgenomes.org/id/AAC75719 EnsemblBacteria AAC75719 http://www.ensemblgenomes.org/id/AAC75719 EnsemblBacteria BAA16537 http://www.ensemblgenomes.org/id/BAA16537 EnsemblBacteria BAA16537 http://www.ensemblgenomes.org/id/BAA16537 EnsemblBacteria BAA16537 http://www.ensemblgenomes.org/id/BAA16537 EnsemblBacteria b2672 http://www.ensemblgenomes.org/id/b2672 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 947157 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947157 HOGENOM HOG000256775 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000256775&db=HOGENOM6 InParanoid P0ADQ7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADQ7 IntAct P0ADQ7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADQ7* InterPro IPR010279 http://www.ebi.ac.uk/interpro/entry/IPR010279 KEGG_Gene ecj:JW2647 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2647 KEGG_Gene eco:b2672 http://www.genome.jp/dbget-bin/www_bget?eco:b2672 MINT MINT-1287856 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1287856 PSORT swissprot:YGAM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGAM_ECOLI PSORT-B swissprot:YGAM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGAM_ECOLI PSORT2 swissprot:YGAM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGAM_ECOLI Pfam PF05957 http://pfam.xfam.org/family/PF05957 Phobius swissprot:YGAM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGAM_ECOLI ProteinModelPortal P0ADQ7 http://www.proteinmodelportal.org/query/uniprot/P0ADQ7 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22661687 http://www.ncbi.nlm.nih.gov/pubmed/22661687 PubMed 8820648 http://www.ncbi.nlm.nih.gov/pubmed/8820648 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417158 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417158 RefSeq WP_001295174 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295174 STRING 511145.b2672 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2672&targetmode=cogs UniProtKB YGAM_ECOLI http://www.uniprot.org/uniprot/YGAM_ECOLI UniProtKB-AC P0ADQ7 http://www.uniprot.org/uniprot/P0ADQ7 charge swissprot:YGAM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGAM_ECOLI eggNOG COG4575 http://eggnogapi.embl.de/nog_data/html/tree/COG4575 eggNOG ENOG4108ZQZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZQZ epestfind swissprot:YGAM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGAM_ECOLI garnier swissprot:YGAM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGAM_ECOLI helixturnhelix swissprot:YGAM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGAM_ECOLI hmoment swissprot:YGAM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGAM_ECOLI iep swissprot:YGAM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGAM_ECOLI inforesidue swissprot:YGAM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGAM_ECOLI octanol swissprot:YGAM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGAM_ECOLI pepcoil swissprot:YGAM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGAM_ECOLI pepdigest swissprot:YGAM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGAM_ECOLI pepinfo swissprot:YGAM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGAM_ECOLI pepnet swissprot:YGAM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGAM_ECOLI pepstats swissprot:YGAM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGAM_ECOLI pepwheel swissprot:YGAM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGAM_ECOLI pepwindow swissprot:YGAM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGAM_ECOLI sigcleave swissprot:YGAM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGAM_ECOLI ## Database ID URL or Descriptions # AltName ACDH_ECOLI Acetaldehyde dehydrogenase [acetylating] # BioGrid 4261622 13 # CATALYTIC ACTIVITY ACDH_ECOLI Acetaldehyde + CoA + NAD(+) = acetyl-CoA + NADH. # EcoGene EG13625 mhpF # FUNCTION ACDH_ECOLI Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of 3-phenylpropanoate. Functions as a chaperone protein for folding of MhpE. {ECO 0000269|PubMed 16782065}. # GO_function GO:0008774 acetaldehyde dehydrogenase (acetylating) activity; IDA:EcoCyc. # GO_function GO:0051287 NAD binding; IEA:UniProtKB-HAMAP. # GO_process GO:0019380 3-phenylpropionate catabolic process; IEA:UniProtKB-UniPathway. # GO_process GO:0019439 aromatic compound catabolic process; IEA:UniProtKB-HAMAP. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.720 -; 1. # HAMAP MF_01657 Ac_ald_DH_ac # IntAct P77580 18 # InterPro IPR000534 Semialdehyde_DH_NAD-bd # InterPro IPR003361 Acetaldehyde_dehydrogenase # InterPro IPR015426 Acetylaldehyde_DH_C # InterPro IPR016040 NAD(P)-bd_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00362 Benzoate degradation # KEGG_Pathway ko00620 Pyruvate metabolism # KEGG_Pathway ko00621 Dioxin degradation # KEGG_Pathway ko00622 Xylene degradation # KEGG_Pathway ko00650 Butanoate metabolism # Organism ACDH_ECOLI Escherichia coli (strain K12) # PATHWAY ACDH_ECOLI Aromatic compound metabolism; 3-phenylpropanoate degradation. # PATRIC 32115835 VBIEscCol129921_0359 # PIR G64762 G64762 # PIRSF PIRSF015689 Actaldh_dh_actl # Pfam PF01118 Semialdhyde_dh # Pfam PF09290 AcetDehyd-dimer # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ACDH_ECOLI Acetaldehyde dehydrogenase # RefSeq NP_414885 NC_000913.3 # RefSeq WP_000044314 NZ_LN832404.1 # SIMILARITY Belongs to the acetaldehyde dehydrogenase family. {ECO 0000305}. # SMART SM00859 Semialdhyde_dh # SUBUNIT Interacts with MhpE. {ECO:0000269|PubMed 16782065}. # SUPFAM SSF51735 SSF51735 # TIGRFAMs TIGR03215 ac_ald_DH_ac # eggNOG COG4569 LUCA # eggNOG ENOG4105DIV Bacteria BLAST swissprot:ACDH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ACDH_ECOLI BioCyc ECOL316407:JW0342-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0342-MONOMER BioCyc EcoCyc:MHPF-MONOMER http://biocyc.org/getid?id=EcoCyc:MHPF-MONOMER BioCyc MetaCyc:MHPF-MONOMER http://biocyc.org/getid?id=MetaCyc:MHPF-MONOMER COG COG0119 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0119 DIP DIP-10210N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10210N DOI 10.1016/j.bbrc.2006.06.009 http://dx.doi.org/10.1016/j.bbrc.2006.06.009 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.2.1.10 http://www.genome.jp/dbget-bin/www_bget?EC:1.2.1.10 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D86239 http://www.ebi.ac.uk/ena/data/view/D86239 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EMBL Y09555 http://www.ebi.ac.uk/ena/data/view/Y09555 ENZYME 1.2.1.10 http://enzyme.expasy.org/EC/1.2.1.10 EchoBASE EB3390 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3390 EcoGene EG13625 http://www.ecogene.org/geneInfo.php?eg_id=EG13625 EnsemblBacteria AAC73454 http://www.ensemblgenomes.org/id/AAC73454 EnsemblBacteria AAC73454 http://www.ensemblgenomes.org/id/AAC73454 EnsemblBacteria BAE76133 http://www.ensemblgenomes.org/id/BAE76133 EnsemblBacteria BAE76133 http://www.ensemblgenomes.org/id/BAE76133 EnsemblBacteria BAE76133 http://www.ensemblgenomes.org/id/BAE76133 EnsemblBacteria b0351 http://www.ensemblgenomes.org/id/b0351 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008774 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008774 GO_function GO:0051287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051287 GO_process GO:0019380 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019380 GO_process GO:0019439 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019439 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 945008 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945008 HAMAP MF_01657 http://hamap.expasy.org/unirule/MF_01657 HOGENOM HOG000052149 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000052149&db=HOGENOM6 InParanoid P77580 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77580 IntAct P77580 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77580* IntEnz 1.2.1.10 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.2.1.10 InterPro IPR000534 http://www.ebi.ac.uk/interpro/entry/IPR000534 InterPro IPR003361 http://www.ebi.ac.uk/interpro/entry/IPR003361 InterPro IPR015426 http://www.ebi.ac.uk/interpro/entry/IPR015426 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0342 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0342 KEGG_Gene eco:b0351 http://www.genome.jp/dbget-bin/www_bget?eco:b0351 KEGG_Orthology KO:K04073 http://www.genome.jp/dbget-bin/www_bget?KO:K04073 KEGG_Pathway ko00362 http://www.genome.jp/kegg-bin/show_pathway?ko00362 KEGG_Pathway ko00620 http://www.genome.jp/kegg-bin/show_pathway?ko00620 KEGG_Pathway ko00621 http://www.genome.jp/kegg-bin/show_pathway?ko00621 KEGG_Pathway ko00622 http://www.genome.jp/kegg-bin/show_pathway?ko00622 KEGG_Pathway ko00650 http://www.genome.jp/kegg-bin/show_pathway?ko00650 KEGG_Reaction rn:R00228 http://www.genome.jp/dbget-bin/www_bget?rn:R00228 KEGG_Reaction rn:R01172 http://www.genome.jp/dbget-bin/www_bget?rn:R01172 OMA QGNVNMV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QGNVNMV PSORT swissprot:ACDH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ACDH_ECOLI PSORT-B swissprot:ACDH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ACDH_ECOLI PSORT2 swissprot:ACDH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ACDH_ECOLI Pfam PF01118 http://pfam.xfam.org/family/PF01118 Pfam PF09290 http://pfam.xfam.org/family/PF09290 Phobius swissprot:ACDH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ACDH_ECOLI PhylomeDB P77580 http://phylomedb.org/?seqid=P77580 ProteinModelPortal P77580 http://www.proteinmodelportal.org/query/uniprot/P77580 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16782065 http://www.ncbi.nlm.nih.gov/pubmed/16782065 PubMed 9098055 http://www.ncbi.nlm.nih.gov/pubmed/9098055 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414885 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414885 RefSeq WP_000044314 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000044314 SMART SM00859 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00859 SMR P77580 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77580 STRING 511145.b0351 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0351&targetmode=cogs STRING COG0119 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0119&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 TIGRFAMs TIGR03215 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03215 UniProtKB ACDH_ECOLI http://www.uniprot.org/uniprot/ACDH_ECOLI UniProtKB-AC P77580 http://www.uniprot.org/uniprot/P77580 charge swissprot:ACDH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ACDH_ECOLI eggNOG COG4569 http://eggnogapi.embl.de/nog_data/html/tree/COG4569 eggNOG ENOG4105DIV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DIV epestfind swissprot:ACDH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ACDH_ECOLI garnier swissprot:ACDH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ACDH_ECOLI helixturnhelix swissprot:ACDH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ACDH_ECOLI hmoment swissprot:ACDH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ACDH_ECOLI iep swissprot:ACDH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ACDH_ECOLI inforesidue swissprot:ACDH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ACDH_ECOLI octanol swissprot:ACDH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ACDH_ECOLI pepcoil swissprot:ACDH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ACDH_ECOLI pepdigest swissprot:ACDH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ACDH_ECOLI pepinfo swissprot:ACDH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ACDH_ECOLI pepnet swissprot:ACDH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ACDH_ECOLI pepstats swissprot:ACDH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ACDH_ECOLI pepwheel swissprot:ACDH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ACDH_ECOLI pepwindow swissprot:ACDH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ACDH_ECOLI sigcleave swissprot:ACDH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ACDH_ECOLI ## Database ID URL or Descriptions # BRENDA 2.7.13 2026 # BioGrid 4263422 370 # CATALYTIC ACTIVITY ARCB_ECOLI ATP + protein L-histidine = ADP + protein N- phospho-L-histidine. # EcoGene EG10062 arcB # FUNCTION ARCB_ECOLI Member of the two-component regulatory system ArcB/ArcA. Sensor-regulator protein for anaerobic repression of the arc modulon. Activates ArcA via a four-step phosphorelay. ArcB can also dephosphorylate ArcA by a reverse phosphorelay involving His- 717 and Asp-576. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IDA:EcoCyc. # GO_function GO:0000155 phosphorelay sensor kinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0009927 histidine phosphotransfer kinase activity; IDA:EcoCyc. # GO_process GO:0000160 phosphorelay signal transduction system; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0046777 protein autophosphorylation; IMP:CACAO. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005622 intracellular # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.287.130 -; 1. # Gene3D 1.10.287.970 -; 1. # Gene3D 1.20.120.160 -; 1. # Gene3D 3.30.565.10 -; 1. # IntAct P0AEC3 7 # InterPro IPR000014 PAS # InterPro IPR000700 PAS-assoc_C # InterPro IPR001789 Sig_transdc_resp-reg_receiver # InterPro IPR003594 HATPase_C # InterPro IPR003661 HisK_dim/P # InterPro IPR004358 Sig_transdc_His_kin-like_C # InterPro IPR005467 His_kinase_dom # InterPro IPR008207 Sig_transdc_His_kin_Hpt_dom # InterPro IPR011006 CheY-like_superfamily # InterPro IPR013767 PAS_fold # InterPro IPR014409 Sig_transdc_His_kin_hyb_ArcB # InterPro IPR027460 ArcB_TM # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01001 Protein kinases # KEGG_Brite ko02022 M00456 ArcB-ArcA (anoxic redox control) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # Organism ARCB_ECOLI Escherichia coli (strain K12) # PATRIC 32121840 VBIEscCol129921_3304 # PDB 1A0B X-ray; 2.06 A; A=654-778 # PDB 1BDJ X-ray; 2.68 A; B=654-778 # PDB 1FR0 NMR; -; A=654-778 # PDB 2A0B X-ray; 1.57 A; A=654-778 # PDB 2KSD NMR; -; A=1-115 # PIR D65112 RGECAR # PIRSF PIRSF003182 ArcB # PRINTS PR00344 BCTRLSENSOR # PROSITE PS50109 HIS_KIN # PROSITE PS50110 RESPONSE_REGULATORY # PROSITE PS50112 PAS # PROSITE PS50113 PAC # PROSITE PS50894 HPT # PTM ARCB_ECOLI Activation requires a sequential transfer of a phosphate group from a His in the primary transmitter domain, to an Asp in the receiver domain and to a His in the secondary transmitter domain. # Pfam PF00072 Response_reg # Pfam PF00512 HisKA # Pfam PF00989 PAS # Pfam PF01627 Hpt # Pfam PF02518 HATPase_c # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ARCB_ECOLI Aerobic respiration control sensor protein ArcB # RefSeq WP_000809774 NZ_LN832404.1 # RefSeq YP_026207 NC_000913.3 # SIMILARITY Contains 1 HPt domain. {ECO:0000255|PROSITE- ProRule PRU00110}. # SIMILARITY Contains 1 PAC (PAS-associated C-terminal) domain. {ECO:0000255|PROSITE-ProRule PRU00141}. # SIMILARITY Contains 1 PAS (PER-ARNT-SIM) domain. {ECO:0000255|PROSITE-ProRule PRU00140}. # SIMILARITY Contains 1 histidine kinase domain. {ECO:0000255|PROSITE-ProRule PRU00107}. # SIMILARITY Contains 1 response regulatory domain. {ECO:0000255|PROSITE-ProRule PRU00169}. # SMART SM00073 HPT # SMART SM00091 PAS # SMART SM00387 HATPase_c # SMART SM00388 HisKA # SMART SM00448 REC # SUBCELLULAR LOCATION ARCB_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # SUPFAM SSF47226 SSF47226 # SUPFAM SSF47384 SSF47384 # SUPFAM SSF52172 SSF52172 # SUPFAM SSF55785 SSF55785 # SUPFAM SSF55874 SSF55874 # TIGRFAMs TIGR00229 sensory_box # eggNOG COG0642 LUCA # eggNOG COG0784 LUCA # eggNOG COG2198 LUCA # eggNOG ENOG4105BZU Bacteria BLAST swissprot:ARCB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARCB_ECOLI BioCyc ECOL316407:JW5536-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5536-MONOMER BioCyc EcoCyc:ARCB-MONOMER http://biocyc.org/getid?id=EcoCyc:ARCB-MONOMER COG COG0642 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0642 DIP DIP-47915N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47915N DOI 10.1016/S0092-8674(00)81914-5 http://dx.doi.org/10.1016/S0092-8674(00)81914-5 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.273.49.32864 http://dx.doi.org/10.1074/jbc.273.49.32864 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1107/S0907444997007075 http://dx.doi.org/10.1107/S0907444997007075 DOI 10.1107/S0907444999010392 http://dx.doi.org/10.1107/S0907444999010392 DOI 10.1111/j.1365-2958.1990.tb00642.x http://dx.doi.org/10.1111/j.1365-2958.1990.tb00642.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.13.3858-3862.2000 http://dx.doi.org/10.1128/JB.182.13.3858-3862.2000 EC_number EC:2.7.13.3 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.13.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X53315 http://www.ebi.ac.uk/ena/data/view/X53315 ENZYME 2.7.13.3 http://enzyme.expasy.org/EC/2.7.13.3 EchoBASE EB0060 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0060 EcoGene EG10062 http://www.ecogene.org/geneInfo.php?eg_id=EG10062 EnsemblBacteria AAT48172 http://www.ensemblgenomes.org/id/AAT48172 EnsemblBacteria AAT48172 http://www.ensemblgenomes.org/id/AAT48172 EnsemblBacteria BAE77254 http://www.ensemblgenomes.org/id/BAE77254 EnsemblBacteria BAE77254 http://www.ensemblgenomes.org/id/BAE77254 EnsemblBacteria BAE77254 http://www.ensemblgenomes.org/id/BAE77254 EnsemblBacteria b3210 http://www.ensemblgenomes.org/id/b3210 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0000155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000155 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0009927 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009927 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0046777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046777 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.287.130 http://www.cathdb.info/version/latest/superfamily/1.10.287.130 Gene3D 1.10.287.970 http://www.cathdb.info/version/latest/superfamily/1.10.287.970 Gene3D 1.20.120.160 http://www.cathdb.info/version/latest/superfamily/1.20.120.160 Gene3D 3.30.565.10 http://www.cathdb.info/version/latest/superfamily/3.30.565.10 GeneID 947887 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947887 HOGENOM HOG000272667 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000272667&db=HOGENOM6 InParanoid P0AEC3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEC3 IntAct P0AEC3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEC3* IntEnz 2.7.13.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.13.3 InterPro IPR000014 http://www.ebi.ac.uk/interpro/entry/IPR000014 InterPro IPR000700 http://www.ebi.ac.uk/interpro/entry/IPR000700 InterPro IPR001789 http://www.ebi.ac.uk/interpro/entry/IPR001789 InterPro IPR003594 http://www.ebi.ac.uk/interpro/entry/IPR003594 InterPro IPR003661 http://www.ebi.ac.uk/interpro/entry/IPR003661 InterPro IPR004358 http://www.ebi.ac.uk/interpro/entry/IPR004358 InterPro IPR005467 http://www.ebi.ac.uk/interpro/entry/IPR005467 InterPro IPR008207 http://www.ebi.ac.uk/interpro/entry/IPR008207 InterPro IPR011006 http://www.ebi.ac.uk/interpro/entry/IPR011006 InterPro IPR013767 http://www.ebi.ac.uk/interpro/entry/IPR013767 InterPro IPR014409 http://www.ebi.ac.uk/interpro/entry/IPR014409 InterPro IPR027460 http://www.ebi.ac.uk/interpro/entry/IPR027460 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01001 http://www.genome.jp/dbget-bin/www_bget?ko01001 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW5536 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5536 KEGG_Gene eco:b3210 http://www.genome.jp/dbget-bin/www_bget?eco:b3210 KEGG_Orthology KO:K07648 http://www.genome.jp/dbget-bin/www_bget?KO:K07648 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 MINT MINT-98513 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-98513 OMA IGSSIMR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IGSSIMR PDB 1A0B http://www.ebi.ac.uk/pdbe-srv/view/entry/1A0B PDB 1BDJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1BDJ PDB 1FR0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1FR0 PDB 2A0B http://www.ebi.ac.uk/pdbe-srv/view/entry/2A0B PDB 2KSD http://www.ebi.ac.uk/pdbe-srv/view/entry/2KSD PDBsum 1A0B http://www.ebi.ac.uk/pdbsum/1A0B PDBsum 1BDJ http://www.ebi.ac.uk/pdbsum/1BDJ PDBsum 1FR0 http://www.ebi.ac.uk/pdbsum/1FR0 PDBsum 2A0B http://www.ebi.ac.uk/pdbsum/2A0B PDBsum 2KSD http://www.ebi.ac.uk/pdbsum/2KSD PRINTS PR00344 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00344 PROSITE PS50109 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50109 PROSITE PS50110 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50110 PROSITE PS50112 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50112 PROSITE PS50113 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50113 PROSITE PS50894 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50894 PSORT swissprot:ARCB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARCB_ECOLI PSORT-B swissprot:ARCB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARCB_ECOLI PSORT2 swissprot:ARCB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARCB_ECOLI Pfam PF00072 http://pfam.xfam.org/family/PF00072 Pfam PF00512 http://pfam.xfam.org/family/PF00512 Pfam PF00989 http://pfam.xfam.org/family/PF00989 Pfam PF01627 http://pfam.xfam.org/family/PF01627 Pfam PF02518 http://pfam.xfam.org/family/PF02518 Phobius swissprot:ARCB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARCB_ECOLI PhylomeDB P0AEC3 http://phylomedb.org/?seqid=P0AEC3 ProteinModelPortal P0AEC3 http://www.proteinmodelportal.org/query/uniprot/P0AEC3 PubMed 10531481 http://www.ncbi.nlm.nih.gov/pubmed/10531481 PubMed 10851007 http://www.ncbi.nlm.nih.gov/pubmed/10851007 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2201868 http://www.ncbi.nlm.nih.gov/pubmed/2201868 PubMed 9054511 http://www.ncbi.nlm.nih.gov/pubmed/9054511 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9286997 http://www.ncbi.nlm.nih.gov/pubmed/9286997 PubMed 9761838 http://www.ncbi.nlm.nih.gov/pubmed/9761838 PubMed 9830034 http://www.ncbi.nlm.nih.gov/pubmed/9830034 RefSeq WP_000809774 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000809774 RefSeq YP_026207 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026207 SMART SM00073 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00073 SMART SM00091 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00091 SMART SM00387 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00387 SMART SM00388 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00388 SMART SM00448 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00448 SMR P0AEC3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEC3 STRING 511145.b3210 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3210&targetmode=cogs STRING COG0642 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0642&targetmode=cogs SUPFAM SSF47226 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47226 SUPFAM SSF47384 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47384 SUPFAM SSF52172 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52172 SUPFAM SSF55785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55785 SUPFAM SSF55874 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55874 TIGRFAMs TIGR00229 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00229 UniProtKB ARCB_ECOLI http://www.uniprot.org/uniprot/ARCB_ECOLI UniProtKB-AC P0AEC3 http://www.uniprot.org/uniprot/P0AEC3 charge swissprot:ARCB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARCB_ECOLI eggNOG COG0642 http://eggnogapi.embl.de/nog_data/html/tree/COG0642 eggNOG COG0784 http://eggnogapi.embl.de/nog_data/html/tree/COG0784 eggNOG COG2198 http://eggnogapi.embl.de/nog_data/html/tree/COG2198 eggNOG ENOG4105BZU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZU epestfind swissprot:ARCB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARCB_ECOLI garnier swissprot:ARCB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARCB_ECOLI helixturnhelix swissprot:ARCB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARCB_ECOLI hmoment swissprot:ARCB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARCB_ECOLI iep swissprot:ARCB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARCB_ECOLI inforesidue swissprot:ARCB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARCB_ECOLI octanol swissprot:ARCB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARCB_ECOLI pepcoil swissprot:ARCB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARCB_ECOLI pepdigest swissprot:ARCB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARCB_ECOLI pepinfo swissprot:ARCB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARCB_ECOLI pepnet swissprot:ARCB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARCB_ECOLI pepstats swissprot:ARCB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARCB_ECOLI pepwheel swissprot:ARCB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARCB_ECOLI pepwindow swissprot:ARCB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARCB_ECOLI sigcleave swissprot:ARCB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARCB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260909 9 # DISRUPTION PHENOTYPE Mutants are unable to use DNA as a sole carbon and energy source. {ECO:0000269|PubMed 16707682}. # EcoGene EG12925 hofM # FUNCTION HOFM_ECOLI Required for the use of extracellular DNA as a nutrient. {ECO 0000269|PubMed 16707682}. # GO_process GO:0015976 carbon utilization; IMP:EcoCyc. # GOslim_process GO:0008150 biological_process # KEGG_Brite ko02044 Secretion system # Organism HOFM_ECOLI Escherichia coli (strain K12) # PATRIC 32122222 VBIEscCol129921_3488 # PIR F65134 F65134 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HOFM_ECOLI Putative DNA utilization protein HofM # RefSeq NP_417854 NC_000913.3 # RefSeq WP_001295166 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA58192.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # eggNOG ENOG4108U1Q Bacteria # eggNOG ENOG4111I00 LUCA BLAST swissprot:HOFM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HOFM_ECOLI BioCyc ECOL316407:JW5693-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5693-MONOMER BioCyc EcoCyc:G7739-MONOMER http://biocyc.org/getid?id=EcoCyc:G7739-MONOMER DIP DIP-12921N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12921N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01974-05 http://dx.doi.org/10.1128/JB.01974-05 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2761 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2761 EcoGene EG12925 http://www.ecogene.org/geneInfo.php?eg_id=EG12925 EnsemblBacteria AAC76420 http://www.ensemblgenomes.org/id/AAC76420 EnsemblBacteria AAC76420 http://www.ensemblgenomes.org/id/AAC76420 EnsemblBacteria BAE77896 http://www.ensemblgenomes.org/id/BAE77896 EnsemblBacteria BAE77896 http://www.ensemblgenomes.org/id/BAE77896 EnsemblBacteria BAE77896 http://www.ensemblgenomes.org/id/BAE77896 EnsemblBacteria b3395 http://www.ensemblgenomes.org/id/b3395 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0015976 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015976 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 947908 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947908 HOGENOM HOG000125553 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125553&db=HOGENOM6 IntAct P45753 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45753* KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW5693 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5693 KEGG_Gene eco:b3395 http://www.genome.jp/dbget-bin/www_bget?eco:b3395 KEGG_Orthology KO:K12288 http://www.genome.jp/dbget-bin/www_bget?KO:K12288 MINT MINT-1288735 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1288735 OMA TMAFKIW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TMAFKIW PSORT swissprot:HOFM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HOFM_ECOLI PSORT-B swissprot:HOFM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HOFM_ECOLI PSORT2 swissprot:HOFM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HOFM_ECOLI Phobius swissprot:HOFM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HOFM_ECOLI ProteinModelPortal P45753 http://www.proteinmodelportal.org/query/uniprot/P45753 PubMed 16707682 http://www.ncbi.nlm.nih.gov/pubmed/16707682 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417854 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417854 RefSeq WP_001295166 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295166 SMR P45753 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45753 STRING 511145.b3395 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3395&targetmode=cogs UniProtKB HOFM_ECOLI http://www.uniprot.org/uniprot/HOFM_ECOLI UniProtKB-AC P45753 http://www.uniprot.org/uniprot/P45753 charge swissprot:HOFM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HOFM_ECOLI eggNOG ENOG4108U1Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108U1Q eggNOG ENOG4111I00 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111I00 epestfind swissprot:HOFM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HOFM_ECOLI garnier swissprot:HOFM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HOFM_ECOLI helixturnhelix swissprot:HOFM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HOFM_ECOLI hmoment swissprot:HOFM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HOFM_ECOLI iep swissprot:HOFM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HOFM_ECOLI inforesidue swissprot:HOFM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HOFM_ECOLI octanol swissprot:HOFM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HOFM_ECOLI pepcoil swissprot:HOFM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HOFM_ECOLI pepdigest swissprot:HOFM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HOFM_ECOLI pepinfo swissprot:HOFM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HOFM_ECOLI pepnet swissprot:HOFM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HOFM_ECOLI pepstats swissprot:HOFM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HOFM_ECOLI pepwheel swissprot:HOFM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HOFM_ECOLI pepwindow swissprot:HOFM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HOFM_ECOLI sigcleave swissprot:HOFM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HOFM_ECOLI ## Database ID URL or Descriptions # AltName PPIB_ECOLI Rotamase B # BioGrid 4262014 14 # CATALYTIC ACTIVITY PPIB_ECOLI Peptidylproline (omega=180) = peptidylproline (omega=0). # ENZYME REGULATION PPIB_ECOLI Inhibition by cyclosporin A with a Ki of 25 to 50 mu-mol, a concentration 100-fold higher than that required for eukaryotic PPIases. # EcoGene EG10758 ppiB # FUNCTION PPIB_ECOLI PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003755 peptidyl-prolyl cis-trans isomerase activity; IDA:EcoCyc. # GO_process GO:0006457 protein folding; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0006457 protein folding # Gene3D 2.40.100.10 -; 1. # INTERACTION PPIB_ECOLI P16918 rhsC; NbExp=4; IntAct=EBI-555935, EBI-546818; # IntAct P23869 23 # InterPro IPR002130 Cyclophilin-type_PPIase_dom # InterPro IPR020892 Cyclophilin-type_PPIase_CS # InterPro IPR024936 Cyclophilin-type_PPIase # InterPro IPR029000 Cyclophilin-like_dom # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03110 Chaperones and folding catalysts # Organism PPIB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11071 PTHR11071 # PATRIC 32116210 VBIEscCol129921_0546 # PDB 1LOP X-ray; 1.80 A; A=1-164 # PDB 2NUL X-ray; 2.10 A; A=1-164 # PDB 2RS4 NMR; -; A=1-164 # PIR D64784 CSECB # PIRSF PIRSF001467 Peptidylpro_ismrse # PRINTS PR00153 CSAPPISMRASE # PROSITE PS00170 CSA_PPIASE_1 # PROSITE PS50072 CSA_PPIASE_2 # Pfam PF00160 Pro_isomerase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PPIB_ECOLI Peptidyl-prolyl cis-trans isomerase B # RefSeq NP_415058 NC_000913.3 # RefSeq WP_000255997 NZ_LN832404.1 # SIMILARITY Belongs to the cyclophilin-type PPIase family. {ECO 0000305}. # SIMILARITY Contains 1 PPIase cyclophilin-type domain. {ECO:0000255|PROSITE-ProRule PRU00156}. # SUBCELLULAR LOCATION PPIB_ECOLI Cytoplasm. # SUPFAM SSF50891 SSF50891 # eggNOG COG0652 LUCA # eggNOG ENOG4108R5K Bacteria BLAST swissprot:PPIB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PPIB_ECOLI BioCyc ECOL316407:JW0514-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0514-MONOMER BioCyc EcoCyc:EG10758-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10758-MONOMER BioCyc MetaCyc:EG10758-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10758-MONOMER COG COG0652 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0652 DIP DIP-10546N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10546N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1996.0136 http://dx.doi.org/10.1006/jmbi.1996.0136 DOI 10.1006/jmbi.1998.1726 http://dx.doi.org/10.1006/jmbi.1998.1726 DOI 10.1016/0014-5793(91)80968-9 http://dx.doi.org/10.1016/0014-5793(91)80968-9 DOI 10.1021/bi00226a009 http://dx.doi.org/10.1021/bi00226a009 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1432-1033.1992.tb17002.x http://dx.doi.org/10.1111/j.1432-1033.1992.tb17002.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.2.1.8 http://www.genome.jp/dbget-bin/www_bget?EC:5.2.1.8 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M55430 http://www.ebi.ac.uk/ena/data/view/M55430 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X59293 http://www.ebi.ac.uk/ena/data/view/X59293 ENZYME 5.2.1.8 http://enzyme.expasy.org/EC/5.2.1.8 EchoBASE EB0751 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0751 EcoGene EG10758 http://www.ecogene.org/geneInfo.php?eg_id=EG10758 EnsemblBacteria AAC73627 http://www.ensemblgenomes.org/id/AAC73627 EnsemblBacteria AAC73627 http://www.ensemblgenomes.org/id/AAC73627 EnsemblBacteria BAE76302 http://www.ensemblgenomes.org/id/BAE76302 EnsemblBacteria BAE76302 http://www.ensemblgenomes.org/id/BAE76302 EnsemblBacteria BAE76302 http://www.ensemblgenomes.org/id/BAE76302 EnsemblBacteria b0525 http://www.ensemblgenomes.org/id/b0525 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003755 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003755 GO_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 Gene3D 2.40.100.10 http://www.cathdb.info/version/latest/superfamily/2.40.100.10 GeneID 949038 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949038 HOGENOM HOG000065978 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000065978&db=HOGENOM6 InParanoid P23869 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23869 IntAct P23869 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P23869* IntEnz 5.2.1.8 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.2.1.8 InterPro IPR002130 http://www.ebi.ac.uk/interpro/entry/IPR002130 InterPro IPR020892 http://www.ebi.ac.uk/interpro/entry/IPR020892 InterPro IPR024936 http://www.ebi.ac.uk/interpro/entry/IPR024936 InterPro IPR029000 http://www.ebi.ac.uk/interpro/entry/IPR029000 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW0514 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0514 KEGG_Gene eco:b0525 http://www.genome.jp/dbget-bin/www_bget?eco:b0525 KEGG_Orthology KO:K03768 http://www.genome.jp/dbget-bin/www_bget?KO:K03768 MINT MINT-1289871 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1289871 OMA GMKQKST http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GMKQKST PANTHER PTHR11071 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11071 PDB 1LOP http://www.ebi.ac.uk/pdbe-srv/view/entry/1LOP PDB 2NUL http://www.ebi.ac.uk/pdbe-srv/view/entry/2NUL PDB 2RS4 http://www.ebi.ac.uk/pdbe-srv/view/entry/2RS4 PDBsum 1LOP http://www.ebi.ac.uk/pdbsum/1LOP PDBsum 2NUL http://www.ebi.ac.uk/pdbsum/2NUL PDBsum 2RS4 http://www.ebi.ac.uk/pdbsum/2RS4 PRINTS PR00153 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00153 PROSITE PS00170 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00170 PROSITE PS50072 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50072 PSORT swissprot:PPIB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PPIB_ECOLI PSORT-B swissprot:PPIB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PPIB_ECOLI PSORT2 swissprot:PPIB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PPIB_ECOLI Pfam PF00160 http://pfam.xfam.org/family/PF00160 Phobius swissprot:PPIB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PPIB_ECOLI PhylomeDB P23869 http://phylomedb.org/?seqid=P23869 ProteinModelPortal P23869 http://www.proteinmodelportal.org/query/uniprot/P23869 PubMed 1606970 http://www.ncbi.nlm.nih.gov/pubmed/1606970 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1864365 http://www.ncbi.nlm.nih.gov/pubmed/1864365 PubMed 2007139 http://www.ncbi.nlm.nih.gov/pubmed/2007139 PubMed 8601841 http://www.ncbi.nlm.nih.gov/pubmed/8601841 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 RefSeq NP_415058 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415058 RefSeq WP_000255997 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000255997 SMR P23869 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P23869 STRING 511145.b0525 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0525&targetmode=cogs STRING COG0652 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0652&targetmode=cogs SUPFAM SSF50891 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50891 SWISS-2DPAGE P23869 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P23869 UniProtKB PPIB_ECOLI http://www.uniprot.org/uniprot/PPIB_ECOLI UniProtKB-AC P23869 http://www.uniprot.org/uniprot/P23869 charge swissprot:PPIB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PPIB_ECOLI eggNOG COG0652 http://eggnogapi.embl.de/nog_data/html/tree/COG0652 eggNOG ENOG4108R5K http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108R5K epestfind swissprot:PPIB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PPIB_ECOLI garnier swissprot:PPIB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PPIB_ECOLI helixturnhelix swissprot:PPIB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PPIB_ECOLI hmoment swissprot:PPIB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PPIB_ECOLI iep swissprot:PPIB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PPIB_ECOLI inforesidue swissprot:PPIB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PPIB_ECOLI octanol swissprot:PPIB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PPIB_ECOLI pepcoil swissprot:PPIB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PPIB_ECOLI pepdigest swissprot:PPIB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PPIB_ECOLI pepinfo swissprot:PPIB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PPIB_ECOLI pepnet swissprot:PPIB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PPIB_ECOLI pepstats swissprot:PPIB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PPIB_ECOLI pepwheel swissprot:PPIB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PPIB_ECOLI pepwindow swissprot:PPIB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PPIB_ECOLI sigcleave swissprot:PPIB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PPIB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260389 21 # EcoGene EG20267 fliJ # FUNCTION FLIJ_ECOLI The FliJ protein is a flagellar protein that affects chemotactic events. Mutations in FliJ results in failure to respond to chemotactic stimuli. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0009288 bacterial-type flagellum; IEA:InterPro. # GO_function GO:0003774 motor activity; IEA:InterPro. # GO_process GO:0006935 chemotaxis; IEA:UniProtKB-KW. # GO_process GO:0015031 protein transport; IEA:UniProtKB-KW. # GO_process GO:0044781 bacterial-type flagellum organization; IEA:UniProtKB-KW. # GO_process GO:0071973 bacterial-type flagellum-dependent cell motility; IEA:InterPro. # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043226 organelle # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # GOslim_process GO:0040011 locomotion # GOslim_process GO:0048870 cell motility # IntAct P52613 11 # InterPro IPR012823 Flagell_FliJ # InterPro IPR018006 Flag_FliJ_proteobac # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Pathway ko02040 Flagellar assembly # Organism FLIJ_ECOLI Escherichia coli (strain K12) # PATRIC 32119213 VBIEscCol129921_2021 # PIR C64958 C64958 # PIRSF PIRSF019404 FliJ # PRINTS PR01004 FLGFLIJ # Pfam PF02050 FliJ # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FLIJ_ECOLI Flagellar FliJ protein # RefSeq NP_416452 NC_000913.3 # RefSeq WP_000807579 NZ_LN832404.1 # SIMILARITY Belongs to the FliJ family. {ECO 0000305}. # SUBCELLULAR LOCATION FLIJ_ECOLI Cell membrane; Peripheral membrane protein; Cytoplasmic side. # TIGRFAMs TIGR02473 flagell_FliJ # eggNOG COG2882 LUCA # eggNOG ENOG4105GSA Bacteria BLAST swissprot:FLIJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLIJ_ECOLI BioCyc ECOL316407:JW1926-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1926-MONOMER BioCyc EcoCyc:G378-MONOMER http://biocyc.org/getid?id=EcoCyc:G378-MONOMER COG COG2882 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2882 DIP DIP-9656N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9656N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L43491 http://www.ebi.ac.uk/ena/data/view/L43491 EMBL L49147 http://www.ebi.ac.uk/ena/data/view/L49147 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4164 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4164 EcoGene EG20267 http://www.ecogene.org/geneInfo.php?eg_id=EG20267 EnsemblBacteria AAC75009 http://www.ensemblgenomes.org/id/AAC75009 EnsemblBacteria AAC75009 http://www.ensemblgenomes.org/id/AAC75009 EnsemblBacteria BAA15767 http://www.ensemblgenomes.org/id/BAA15767 EnsemblBacteria BAA15767 http://www.ensemblgenomes.org/id/BAA15767 EnsemblBacteria BAA15767 http://www.ensemblgenomes.org/id/BAA15767 EnsemblBacteria b1942 http://www.ensemblgenomes.org/id/b1942 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0009288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009288 GO_function GO:0003774 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003774 GO_process GO:0006935 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006935 GO_process GO:0015031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031 GO_process GO:0044781 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044781 GO_process GO:0071973 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071973 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0040011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 GeneID 946454 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946454 HOGENOM HOG000265872 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000265872&db=HOGENOM6 InParanoid P52613 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P52613 IntAct P52613 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P52613* InterPro IPR012823 http://www.ebi.ac.uk/interpro/entry/IPR012823 InterPro IPR018006 http://www.ebi.ac.uk/interpro/entry/IPR018006 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW1926 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1926 KEGG_Gene eco:b1942 http://www.genome.jp/dbget-bin/www_bget?eco:b1942 KEGG_Orthology KO:K02413 http://www.genome.jp/dbget-bin/www_bget?KO:K02413 KEGG_Pathway ko02040 http://www.genome.jp/kegg-bin/show_pathway?ko02040 MINT MINT-1258288 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1258288 OMA QMDEYAQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QMDEYAQ PRINTS PR01004 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01004 PSORT swissprot:FLIJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLIJ_ECOLI PSORT-B swissprot:FLIJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLIJ_ECOLI PSORT2 swissprot:FLIJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLIJ_ECOLI Pfam PF02050 http://pfam.xfam.org/family/PF02050 Phobius swissprot:FLIJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLIJ_ECOLI ProteinModelPortal P52613 http://www.proteinmodelportal.org/query/uniprot/P52613 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8631687 http://www.ncbi.nlm.nih.gov/pubmed/8631687 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416452 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416452 RefSeq WP_000807579 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000807579 SMR P52613 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P52613 STRING 511145.b1942 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1942&targetmode=cogs STRING COG2882 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2882&targetmode=cogs TIGRFAMs TIGR02473 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02473 UniProtKB FLIJ_ECOLI http://www.uniprot.org/uniprot/FLIJ_ECOLI UniProtKB-AC P52613 http://www.uniprot.org/uniprot/P52613 charge swissprot:FLIJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLIJ_ECOLI eggNOG COG2882 http://eggnogapi.embl.de/nog_data/html/tree/COG2882 eggNOG ENOG4105GSA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105GSA epestfind swissprot:FLIJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLIJ_ECOLI garnier swissprot:FLIJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLIJ_ECOLI helixturnhelix swissprot:FLIJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLIJ_ECOLI hmoment swissprot:FLIJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLIJ_ECOLI iep swissprot:FLIJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLIJ_ECOLI inforesidue swissprot:FLIJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLIJ_ECOLI octanol swissprot:FLIJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLIJ_ECOLI pepcoil swissprot:FLIJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLIJ_ECOLI pepdigest swissprot:FLIJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLIJ_ECOLI pepinfo swissprot:FLIJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLIJ_ECOLI pepnet swissprot:FLIJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLIJ_ECOLI pepstats swissprot:FLIJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLIJ_ECOLI pepwheel swissprot:FLIJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLIJ_ECOLI pepwindow swissprot:FLIJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLIJ_ECOLI sigcleave swissprot:FLIJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLIJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4263415 377 # EcoGene EG11180 mscL # FUNCTION MSCL_ECOLI Mechanosensitive channel that opens in response to stretch forces in the membrane lipid bilayer. Participates in the regulation of osmotic pressure changes within the cell. Forms a nonselective ion channel of 2.5 nanosiemens conductance. Opens at a pressure just below that which would cause cell disruption and death. {ECO 0000269|PubMed 10202137, ECO 0000269|PubMed 7511799}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_component GO:0016021 integral component of membrane; IDA:EcoliWiki. # GO_function GO:0008381 mechanically-gated ion channel activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0006811 ion transport; IDA:EcoliWiki. # GO_process GO:0034220 ion transmembrane transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # Gene3D 1.20.5.220 -; 1. # HAMAP MF_00115 MscL # INTERACTION MSCL_ECOLI Self; NbExp=2; IntAct=EBI-909797, EBI-909797; # InterPro IPR001185 MS_channel # InterPro IPR019823 Mechanosensitive_channel_CS # InterPro IPR029027 Single_a-helix # KEGG_Brite ko02000 Transporters # Organism MSCL_ECOLI Escherichia coli (strain K12) # PATRIC 32122014 VBIEscCol129921_3384 # PDB 1KYK Model; -; A/B/C/D/E=14-96 # PDB 1KYL Model; -; A/B/C/D/E=14-96 # PDB 1KYM Model; -; A/B/C/D/E=14-96 # PIR I53826 I53826 # PRINTS PR01264 MECHCHANNEL # PROSITE PS01327 MSCL # Pfam PF01741 MscL # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MSCL_ECOLI Large-conductance mechanosensitive channel # RefSeq NP_417749 NC_000913.3 # RefSeq WP_000022442 NZ_LN832404.1 # SIMILARITY Belongs to the MscL family. {ECO 0000305}. # SUBCELLULAR LOCATION MSCL_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 8890153}; Multi- pass membrane protein {ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 8890153}. # SUBUNIT Homopentamer. {ECO:0000269|PubMed 8890153}. # SUPFAM SSF81330 SSF81330 # TCDB 1.A.22.1 the large conductance mechanosensitive ion channel (mscl) family # TIGRFAMs TIGR00220 mscL # eggNOG COG1970 LUCA # eggNOG ENOG4105M2E Bacteria BLAST swissprot:MSCL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MSCL_ECOLI BioCyc ECOL316407:JW3252-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3252-MONOMER BioCyc EcoCyc:EG11180-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11180-MONOMER COG COG1970 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1970 DIP DIP-29827N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-29827N DOI 10.1016/0378-1119(94)90847-8 http://dx.doi.org/10.1016/0378-1119(94)90847-8 DOI 10.1038/368265a0 http://dx.doi.org/10.1038/368265a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/emboj/18.7.1730 http://dx.doi.org/10.1093/emboj/18.7.1730 DOI 10.1111/j.1365-2958.1993.tb01714.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb01714.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1126/science.282.5397.2220 http://dx.doi.org/10.1126/science.282.5397.2220 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L29458 http://www.ebi.ac.uk/ena/data/view/L29458 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U08371 http://www.ebi.ac.uk/ena/data/view/U08371 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X52114 http://www.ebi.ac.uk/ena/data/view/X52114 EchoBASE EB1167 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1167 EcoGene EG11180 http://www.ecogene.org/geneInfo.php?eg_id=EG11180 EnsemblBacteria AAC76316 http://www.ensemblgenomes.org/id/AAC76316 EnsemblBacteria AAC76316 http://www.ensemblgenomes.org/id/AAC76316 EnsemblBacteria BAE78001 http://www.ensemblgenomes.org/id/BAE78001 EnsemblBacteria BAE78001 http://www.ensemblgenomes.org/id/BAE78001 EnsemblBacteria BAE78001 http://www.ensemblgenomes.org/id/BAE78001 EnsemblBacteria b3291 http://www.ensemblgenomes.org/id/b3291 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008381 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008381 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0006811 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811 GO_process GO:0034220 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 1.20.5.220 http://www.cathdb.info/version/latest/superfamily/1.20.5.220 GeneID 947787 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947787 HAMAP MF_00115 http://hamap.expasy.org/unirule/MF_00115 HOGENOM HOG000226782 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000226782&db=HOGENOM6 InParanoid P0A742 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A742 InterPro IPR001185 http://www.ebi.ac.uk/interpro/entry/IPR001185 InterPro IPR019823 http://www.ebi.ac.uk/interpro/entry/IPR019823 InterPro IPR029027 http://www.ebi.ac.uk/interpro/entry/IPR029027 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3252 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3252 KEGG_Gene eco:b3291 http://www.genome.jp/dbget-bin/www_bget?eco:b3291 KEGG_Orthology KO:K03282 http://www.genome.jp/dbget-bin/www_bget?KO:K03282 MINT MINT-8071627 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8071627 OMA TEFKEFA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TEFKEFA PDB 1KYK http://www.ebi.ac.uk/pdbe-srv/view/entry/1KYK PDB 1KYL http://www.ebi.ac.uk/pdbe-srv/view/entry/1KYL PDB 1KYM http://www.ebi.ac.uk/pdbe-srv/view/entry/1KYM PDBsum 1KYK http://www.ebi.ac.uk/pdbsum/1KYK PDBsum 1KYL http://www.ebi.ac.uk/pdbsum/1KYL PDBsum 1KYM http://www.ebi.ac.uk/pdbsum/1KYM PRINTS PR01264 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01264 PROSITE PS01327 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01327 PSORT swissprot:MSCL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MSCL_ECOLI PSORT-B swissprot:MSCL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MSCL_ECOLI PSORT2 swissprot:MSCL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MSCL_ECOLI Pfam PF01741 http://pfam.xfam.org/family/PF01741 Phobius swissprot:MSCL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MSCL_ECOLI PhylomeDB P0A742 http://phylomedb.org/?seqid=P0A742 ProteinModelPortal P0A742 http://www.proteinmodelportal.org/query/uniprot/P0A742 PubMed 10202137 http://www.ncbi.nlm.nih.gov/pubmed/10202137 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7511799 http://www.ncbi.nlm.nih.gov/pubmed/7511799 PubMed 8063098 http://www.ncbi.nlm.nih.gov/pubmed/8063098 PubMed 8412700 http://www.ncbi.nlm.nih.gov/pubmed/8412700 PubMed 8890153 http://www.ncbi.nlm.nih.gov/pubmed/8890153 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9856938 http://www.ncbi.nlm.nih.gov/pubmed/9856938 RefSeq NP_417749 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417749 RefSeq WP_000022442 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000022442 SMR P0A742 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A742 STRING 511145.b3291 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3291&targetmode=cogs STRING COG1970 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1970&targetmode=cogs SUPFAM SSF81330 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81330 TCDB 1.A.22.1 http://www.tcdb.org/search/result.php?tc=1.A.22.1 TIGRFAMs TIGR00220 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00220 UniProtKB MSCL_ECOLI http://www.uniprot.org/uniprot/MSCL_ECOLI UniProtKB-AC P0A742 http://www.uniprot.org/uniprot/P0A742 charge swissprot:MSCL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MSCL_ECOLI eggNOG COG1970 http://eggnogapi.embl.de/nog_data/html/tree/COG1970 eggNOG ENOG4105M2E http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105M2E epestfind swissprot:MSCL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MSCL_ECOLI garnier swissprot:MSCL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MSCL_ECOLI helixturnhelix swissprot:MSCL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MSCL_ECOLI hmoment swissprot:MSCL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MSCL_ECOLI iep swissprot:MSCL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MSCL_ECOLI inforesidue swissprot:MSCL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MSCL_ECOLI octanol swissprot:MSCL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MSCL_ECOLI pepcoil swissprot:MSCL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MSCL_ECOLI pepdigest swissprot:MSCL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MSCL_ECOLI pepinfo swissprot:MSCL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MSCL_ECOLI pepnet swissprot:MSCL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MSCL_ECOLI pepstats swissprot:MSCL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MSCL_ECOLI pepwheel swissprot:MSCL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MSCL_ECOLI pepwindow swissprot:MSCL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MSCL_ECOLI sigcleave swissprot:MSCL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MSCL_ECOLI ## Database ID URL or Descriptions # BioGrid 4259898 146 # EcoGene EG10297 fepE # FUNCTION FEPE_ECOLI Part of the ferric enterobactin transport system. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015620 ferric-enterobactin transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IEA:InterPro. # GO_process GO:0015685 ferric-enterobactin transport; IMP:EcoCyc. # GO_process GO:0055072 iron ion homeostasis; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0006810 transport # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0042592 homeostatic process # INDUCTION Repressed by H-NS, induced by LeuO. A monocistronic operon. {ECO:0000269|PubMed 19429622}. # IntAct P26266 9 # InterPro IPR003856 LipoPS_biosynth # Organism FEPE_ECOLI Escherichia coli (strain K12) # PATRIC 32116350 VBIEscCol129921_0615 # PIR S34703 S34703 # Pfam PF02706 Wzz # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FEPE_ECOLI Ferric enterobactin transport protein FepE # RefSeq NP_415119 NC_000913.3 # RefSeq WP_000096692 NZ_LN832404.1 # SIMILARITY Belongs to the WzzB/Cld/Rol family. {ECO 0000305}. # SUBCELLULAR LOCATION FEPE_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG COG3765 LUCA # eggNOG ENOG4108QY5 Bacteria BLAST swissprot:FEPE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FEPE_ECOLI BioCyc ECOL316407:JW0579-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0579-MONOMER BioCyc EcoCyc:EG10297-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10297-MONOMER DIP DIP-9596N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9596N DOI 10.1021/bi00225a027 http://dx.doi.org/10.1021/bi00225a027 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00108-09 http://dx.doi.org/10.1128/JB.00108-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M60177 http://www.ebi.ac.uk/ena/data/view/M60177 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EMBL X74129 http://www.ebi.ac.uk/ena/data/view/X74129 EchoBASE EB0293 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0293 EcoGene EG10297 http://www.ecogene.org/geneInfo.php?eg_id=EG10297 EnsemblBacteria AAC73688 http://www.ensemblgenomes.org/id/AAC73688 EnsemblBacteria AAC73688 http://www.ensemblgenomes.org/id/AAC73688 EnsemblBacteria BAE76342 http://www.ensemblgenomes.org/id/BAE76342 EnsemblBacteria BAE76342 http://www.ensemblgenomes.org/id/BAE76342 EnsemblBacteria BAE76342 http://www.ensemblgenomes.org/id/BAE76342 EnsemblBacteria b0587 http://www.ensemblgenomes.org/id/b0587 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015620 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015620 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GO_process GO:0015685 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015685 GO_process GO:0055072 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055072 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GeneID 945180 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945180 HOGENOM HOG000117856 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117856&db=HOGENOM6 InParanoid P26266 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P26266 IntAct P26266 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P26266* InterPro IPR003856 http://www.ebi.ac.uk/interpro/entry/IPR003856 KEGG_Gene ecj:JW0579 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0579 KEGG_Gene eco:b0587 http://www.genome.jp/dbget-bin/www_bget?eco:b0587 OMA RKQDAVM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RKQDAVM PSORT swissprot:FEPE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FEPE_ECOLI PSORT-B swissprot:FEPE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FEPE_ECOLI PSORT2 swissprot:FEPE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FEPE_ECOLI Pfam PF02706 http://pfam.xfam.org/family/PF02706 Phobius swissprot:FEPE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FEPE_ECOLI PhylomeDB P26266 http://phylomedb.org/?seqid=P26266 ProteinModelPortal P26266 http://www.proteinmodelportal.org/query/uniprot/P26266 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1826089 http://www.ncbi.nlm.nih.gov/pubmed/1826089 PubMed 19429622 http://www.ncbi.nlm.nih.gov/pubmed/19429622 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415119 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415119 RefSeq WP_000096692 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000096692 SMR P26266 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P26266 STRING 511145.b0587 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0587&targetmode=cogs UniProtKB FEPE_ECOLI http://www.uniprot.org/uniprot/FEPE_ECOLI UniProtKB-AC P26266 http://www.uniprot.org/uniprot/P26266 charge swissprot:FEPE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FEPE_ECOLI eggNOG COG3765 http://eggnogapi.embl.de/nog_data/html/tree/COG3765 eggNOG ENOG4108QY5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108QY5 epestfind swissprot:FEPE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FEPE_ECOLI garnier swissprot:FEPE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FEPE_ECOLI helixturnhelix swissprot:FEPE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FEPE_ECOLI hmoment swissprot:FEPE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FEPE_ECOLI iep swissprot:FEPE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FEPE_ECOLI inforesidue swissprot:FEPE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FEPE_ECOLI octanol swissprot:FEPE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FEPE_ECOLI pepcoil swissprot:FEPE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FEPE_ECOLI pepdigest swissprot:FEPE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FEPE_ECOLI pepinfo swissprot:FEPE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FEPE_ECOLI pepnet swissprot:FEPE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FEPE_ECOLI pepstats swissprot:FEPE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FEPE_ECOLI pepwheel swissprot:FEPE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FEPE_ECOLI pepwindow swissprot:FEPE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FEPE_ECOLI sigcleave swissprot:FEPE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FEPE_ECOLI ## Database ID URL or Descriptions # DISRUPTION PHENOTYPE RSSB_ECOLI Mutants exhibit nearly constitutively high levels of RpoS and are impaired in the post-transcriptional growth phase-related and osmotic regulation of RpoS. In exponentially growing cells, mutants exhibit significantly reduced levels of polyadenylation and increased stability of specific mRNAs. {ECO 0000269|PubMed 19767441, ECO 0000269|PubMed 8635466}. # DOMAIN RSSB_ECOLI Contains an N-terminal receiver domain and a C-terminal output domain that are both required for binding to RpoS. IraP and IraD interact with the N-terminal domain. IraM interacts with the C-terminal domain and, more weakly, the N-terminal domain. {ECO 0000269|PubMed 11442836, ECO 0000269|PubMed 24352426}. # ENZYME REGULATION RSSB_ECOLI Under certain stress conditions, activity is inhibited by the anti-adapter proteins IraP, IraD and IraM. IraP is involved in response to phosphate stavation, IraD in response to DNA damage and IraM in response to magnesium starvation. IraD and IraM interact with inactive RssB, blocking its ability to interact with RpoS. IraP may mimic RpoS in its interaction with RssB and directly competing with RpoS for binding to RssB. {ECO 0000269|PubMed 16600914, ECO 0000269|PubMed 18383615, ECO 0000269|PubMed 24352426}. # EcoGene EG12121 rssB # FUNCTION RSSB_ECOLI Regulates the turnover of the sigma S factor (RpoS) by promoting its proteolysis in exponentially growing cells. Acts by binding and delivering RpoS to the ClpXP protease. RssB is not co- degraded with RpoS, but is released from the complex and can initiate a new cycle of RpoS recognition and degradation. In stationary phase, could also act as an anti-sigma factor and reduce the ability of RpoS to activate gene expression. Is also involved in the regulation of the mRNA polyadenylation pathway during stationary phase, probably by maintaining the association of PcnB with the degradosome. {ECO 0000255|HAMAP-Rule MF_00958, ECO 0000269|PubMed 10672187, ECO 0000269|PubMed 11442836, ECO 0000269|PubMed 19767441, ECO 0000269|PubMed 20472786, ECO 0000269|PubMed 8635466, ECO 0000269|PubMed 8637901}. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_function GO:0016989 sigma factor antagonist activity; IDA:EcoCyc. # GO_process GO:0000160 phosphorelay signal transduction system; IEA:InterPro. # GO_process GO:0010468 regulation of gene expression; IEA:UniProtKB-HAMAP. # GO_process GO:0031648 protein destabilization; IMP:EcoCyc. # GO_process GO:0045862 positive regulation of proteolysis; IDA:EcoCyc. # GOslim_component GO:0005622 intracellular # GOslim_function GO:0000988 transcription factor activity, protein binding # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # HAMAP MF_00958 RssB # INDUCTION Expression is induced during stationary phase by RpoS. {ECO:0000269|PubMed 10869095}. # IntAct P0AEV1 4 # InterPro IPR001789 Sig_transdc_resp-reg_receiver # InterPro IPR011006 CheY-like_superfamily # InterPro IPR028616 RssB # KEGG_Brite ko02022 Two-component system # Organism RSSB_ECOLI Escherichia coli (strain K12) # PATRIC 32117726 VBIEscCol129921_1283 # PDB 3EOD X-ray; 1.75 A; A=1-130 # PIR A36871 A36871 # PROSITE PS50110 RESPONSE_REGULATORY # PTM RSSB_ECOLI Phosphorylated. Phosphorylation stimulates the interaction with RpoS and, therefore, the proteolysis of RpoS. {ECO 0000255|HAMAP-Rule MF_00958, ECO 0000269|PubMed 10339606, ECO 0000269|PubMed 11442836, ECO 0000269|PubMed 24352426, ECO 0000269|PubMed 9515704}. # Pfam PF00072 Response_reg # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Regulator of RpoS {ECO:0000255|HAMAP-Rule MF_00958} # RefSeq NP_415751 NC_000913.3 # RefSeq WP_000193447 NZ_LN832404.1 # SIMILARITY Belongs to the RssB family. {ECO:0000255|HAMAP- Rule MF_00958}. # SIMILARITY Contains 1 response regulatory domain. {ECO:0000255|PROSITE-ProRule PRU00169}. # SMART SM00448 REC # SUBUNIT RSSB_ECOLI Binds to RpoS with a stoichiometry of 1 1. Interacts with the anti-adapter proteins IraP, IraD and IraM. {ECO 0000255|HAMAP- Rule MF_00958, ECO 0000269|PubMed 10339606, ECO 0000269|PubMed 10672187, ECO 0000269|PubMed 11442836, ECO 0000269|PubMed 16600914, ECO 0000269|PubMed 18383615, ECO 0000269|PubMed 24352426}. # SUPFAM SSF52172 SSF52172 # eggNOG COG0784 LUCA # eggNOG ENOG4105I93 Bacteria BLAST swissprot:RSSB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RSSB_ECOLI BioCyc ECOL316407:JW1223-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1223-MONOMER BioCyc EcoCyc:EG12121-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12121-MONOMER COG COG2197 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2197 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1998.00725.x http://dx.doi.org/10.1046/j.1365-2958.1998.00725.x DOI 10.1046/j.1365-2958.2000.01736.x http://dx.doi.org/10.1046/j.1365-2958.2000.01736.x DOI 10.1046/j.1365-2958.2001.02482.x http://dx.doi.org/10.1046/j.1365-2958.2001.02482.x DOI 10.1073/pnas.93.6.2488 http://dx.doi.org/10.1073/pnas.93.6.2488 DOI 10.1073/pnas.96.11.6439 http://dx.doi.org/10.1073/pnas.96.11.6439 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1101/gad.1400306 http://dx.doi.org/10.1101/gad.1400306 DOI 10.1101/gad.229617.113 http://dx.doi.org/10.1101/gad.229617.113 DOI 10.1111/j.1365-2958.2008.06146.x http://dx.doi.org/10.1111/j.1365-2958.2008.06146.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00300-10 http://dx.doi.org/10.1128/JB.00300-10 DOI 10.1128/JB.00870-09 http://dx.doi.org/10.1128/JB.00870-09 DOI 10.1128/JB.182.14.4117-4120.2000 http://dx.doi.org/10.1128/JB.182.14.4117-4120.2000 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M64675 http://www.ebi.ac.uk/ena/data/view/M64675 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X66003 http://www.ebi.ac.uk/ena/data/view/X66003 EchoBASE EB2042 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2042 EcoGene EG12121 http://www.ecogene.org/geneInfo.php?eg_id=EG12121 EnsemblBacteria AAC74317 http://www.ensemblgenomes.org/id/AAC74317 EnsemblBacteria AAC74317 http://www.ensemblgenomes.org/id/AAC74317 EnsemblBacteria BAA36103 http://www.ensemblgenomes.org/id/BAA36103 EnsemblBacteria BAA36103 http://www.ensemblgenomes.org/id/BAA36103 EnsemblBacteria BAA36103 http://www.ensemblgenomes.org/id/BAA36103 EnsemblBacteria b1235 http://www.ensemblgenomes.org/id/b1235 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_function GO:0016989 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016989 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0010468 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010468 GO_process GO:0031648 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031648 GO_process GO:0045862 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045862 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_function GO:0000988 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000988 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 945855 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945855 HAMAP MF_00958 http://hamap.expasy.org/unirule/MF_00958 HOGENOM HOG000119811 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000119811&db=HOGENOM6 InParanoid P0AEV1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEV1 IntAct P0AEV1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEV1* InterPro IPR001789 http://www.ebi.ac.uk/interpro/entry/IPR001789 InterPro IPR011006 http://www.ebi.ac.uk/interpro/entry/IPR011006 InterPro IPR028616 http://www.ebi.ac.uk/interpro/entry/IPR028616 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW1223 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1223 KEGG_Gene eco:b1235 http://www.genome.jp/dbget-bin/www_bget?eco:b1235 KEGG_Orthology KO:K02485 http://www.genome.jp/dbget-bin/www_bget?KO:K02485 OMA EERLFQD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EERLFQD PDB 3EOD http://www.ebi.ac.uk/pdbe-srv/view/entry/3EOD PDBsum 3EOD http://www.ebi.ac.uk/pdbsum/3EOD PROSITE PS50110 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50110 PSORT swissprot:RSSB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RSSB_ECOLI PSORT-B swissprot:RSSB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RSSB_ECOLI PSORT2 swissprot:RSSB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RSSB_ECOLI Pfam PF00072 http://pfam.xfam.org/family/PF00072 Phobius swissprot:RSSB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RSSB_ECOLI PhylomeDB P0AEV1 http://phylomedb.org/?seqid=P0AEV1 ProteinModelPortal P0AEV1 http://www.proteinmodelportal.org/query/uniprot/P0AEV1 PubMed 10339606 http://www.ncbi.nlm.nih.gov/pubmed/10339606 PubMed 10672187 http://www.ncbi.nlm.nih.gov/pubmed/10672187 PubMed 10869095 http://www.ncbi.nlm.nih.gov/pubmed/10869095 PubMed 11442836 http://www.ncbi.nlm.nih.gov/pubmed/11442836 PubMed 16600914 http://www.ncbi.nlm.nih.gov/pubmed/16600914 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18383615 http://www.ncbi.nlm.nih.gov/pubmed/18383615 PubMed 19767441 http://www.ncbi.nlm.nih.gov/pubmed/19767441 PubMed 20472786 http://www.ncbi.nlm.nih.gov/pubmed/20472786 PubMed 24352426 http://www.ncbi.nlm.nih.gov/pubmed/24352426 PubMed 8282700 http://www.ncbi.nlm.nih.gov/pubmed/8282700 PubMed 8635466 http://www.ncbi.nlm.nih.gov/pubmed/8635466 PubMed 8637901 http://www.ncbi.nlm.nih.gov/pubmed/8637901 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9515704 http://www.ncbi.nlm.nih.gov/pubmed/9515704 RefSeq NP_415751 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415751 RefSeq WP_000193447 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000193447 SMART SM00448 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00448 SMR P0AEV1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEV1 STRING 511145.b1235 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1235&targetmode=cogs STRING COG2197 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2197&targetmode=cogs SUPFAM SSF52172 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52172 UniProtKB RSSB_ECOLI http://www.uniprot.org/uniprot/RSSB_ECOLI UniProtKB-AC P0AEV1 http://www.uniprot.org/uniprot/P0AEV1 charge swissprot:RSSB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RSSB_ECOLI eggNOG COG0784 http://eggnogapi.embl.de/nog_data/html/tree/COG0784 eggNOG ENOG4105I93 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105I93 epestfind swissprot:RSSB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RSSB_ECOLI garnier swissprot:RSSB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RSSB_ECOLI helixturnhelix swissprot:RSSB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RSSB_ECOLI hmoment swissprot:RSSB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RSSB_ECOLI iep swissprot:RSSB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RSSB_ECOLI inforesidue swissprot:RSSB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RSSB_ECOLI octanol swissprot:RSSB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RSSB_ECOLI pepcoil swissprot:RSSB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RSSB_ECOLI pepdigest swissprot:RSSB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RSSB_ECOLI pepinfo swissprot:RSSB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RSSB_ECOLI pepnet swissprot:RSSB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RSSB_ECOLI pepstats swissprot:RSSB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RSSB_ECOLI pepwheel swissprot:RSSB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RSSB_ECOLI pepwindow swissprot:RSSB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RSSB_ECOLI sigcleave swissprot:RSSB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RSSB_ECOLI ## Database ID URL or Descriptions # BioGrid 4262883 8 # EcoGene EG11219 ydcA # Organism YDCA_ECOLI Escherichia coli (strain K12) # PATRIC 32118126 VBIEscCol129921_1483 # PIR F64893 F64893 # PIR S00694 S00694 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDCA_ECOLI Uncharacterized protein YdcA # RefSeq NP_415936 NC_000913.3 # RefSeq WP_000731833 NZ_LN832404.1 # eggNOG ENOG4105UPP Bacteria # eggNOG ENOG4111SBQ LUCA BLAST swissprot:YDCA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDCA_ECOLI BioCyc ECOL316407:JW1416-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1416-MONOMER BioCyc EcoCyc:EG11219-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11219-MONOMER DOI 10.1007/BF00322437 http://dx.doi.org/10.1007/BF00322437 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X07569 http://www.ebi.ac.uk/ena/data/view/X07569 EchoBASE EB1202 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1202 EcoGene EG11219 http://www.ecogene.org/geneInfo.php?eg_id=EG11219 EnsemblBacteria AAC74501 http://www.ensemblgenomes.org/id/AAC74501 EnsemblBacteria AAC74501 http://www.ensemblgenomes.org/id/AAC74501 EnsemblBacteria BAA15040 http://www.ensemblgenomes.org/id/BAA15040 EnsemblBacteria BAA15040 http://www.ensemblgenomes.org/id/BAA15040 EnsemblBacteria BAA15040 http://www.ensemblgenomes.org/id/BAA15040 EnsemblBacteria b1419 http://www.ensemblgenomes.org/id/b1419 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945986 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945986 HOGENOM HOG000277935 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000277935&db=HOGENOM6 IntAct P0ACW4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACW4* KEGG_Gene ecj:JW1416 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1416 KEGG_Gene eco:b1419 http://www.genome.jp/dbget-bin/www_bget?eco:b1419 OMA GKFICND http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GKFICND PSORT swissprot:YDCA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDCA_ECOLI PSORT-B swissprot:YDCA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDCA_ECOLI PSORT2 swissprot:YDCA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDCA_ECOLI Phobius swissprot:YDCA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDCA_ECOLI ProteinModelPortal P0ACW4 http://www.proteinmodelportal.org/query/uniprot/P0ACW4 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2836696 http://www.ncbi.nlm.nih.gov/pubmed/2836696 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415936 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415936 RefSeq WP_000731833 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000731833 SMR P0ACW4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACW4 STRING 511145.b1419 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1419&targetmode=cogs UniProtKB YDCA_ECOLI http://www.uniprot.org/uniprot/YDCA_ECOLI UniProtKB-AC P0ACW4 http://www.uniprot.org/uniprot/P0ACW4 charge swissprot:YDCA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDCA_ECOLI eggNOG ENOG4105UPP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105UPP eggNOG ENOG4111SBQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111SBQ epestfind swissprot:YDCA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDCA_ECOLI garnier swissprot:YDCA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDCA_ECOLI helixturnhelix swissprot:YDCA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDCA_ECOLI hmoment swissprot:YDCA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDCA_ECOLI iep swissprot:YDCA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDCA_ECOLI inforesidue swissprot:YDCA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDCA_ECOLI octanol swissprot:YDCA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDCA_ECOLI pepcoil swissprot:YDCA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDCA_ECOLI pepdigest swissprot:YDCA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDCA_ECOLI pepinfo swissprot:YDCA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDCA_ECOLI pepnet swissprot:YDCA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDCA_ECOLI pepstats swissprot:YDCA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDCA_ECOLI pepwheel swissprot:YDCA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDCA_ECOLI pepwindow swissprot:YDCA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDCA_ECOLI sigcleave swissprot:YDCA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDCA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261021 7 # EcoGene EG11967 flgK # GO_component GO:0005576 extracellular region; IEA:UniProtKB-SubCell. # GO_component GO:0009424 bacterial-type flagellum hook; IEA:InterPro. # GO_function GO:0005198 structural molecule activity; IEA:InterPro. # GO_process GO:0044780 bacterial-type flagellum assembly; IMP:EcoCyc. # GO_process GO:0071973 bacterial-type flagellum-dependent cell motility; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005576 extracellular region # GOslim_function GO:0005198 structural molecule activity # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0048870 cell motility # INTERACTION FLGK_ECOLI P43533 flgN; NbExp=3; IntAct=EBI-551382, EBI-1121833; # IntAct P33235 7 # InterPro IPR001444 Flag_bb_rod_N # InterPro IPR002371 FlgK # InterPro IPR010930 Flg_bb/hook_C_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Pathway ko02040 Flagellar assembly # Organism FLGK_ECOLI Escherichia coli (strain K12) # PATRIC 32117405 VBIEscCol129921_1125 # PIR G64851 G64851 # PRINTS PR01005 FLGHOOKAP1 # Pfam PF00460 Flg_bb_rod # Pfam PF06429 Flg_bbr_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FLGK_ECOLI Flagellar hook-associated protein 1 # RefSeq NP_415600 NC_000913.3 # RefSeq WP_000096479 NZ_LN832404.1 # SIMILARITY Belongs to the flagella basal body rod proteins family. {ECO 0000305}. # SUBCELLULAR LOCATION FLGK_ECOLI Secreted {ECO 0000250}. Bacterial flagellum {ECO 0000250}. # TIGRFAMs TIGR02492 flgK_ends # eggNOG COG1256 LUCA # eggNOG ENOG4105E1Q Bacteria BLAST swissprot:FLGK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLGK_ECOLI BioCyc ECOL316407:JW1069-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1069-MONOMER BioCyc EcoCyc:EG11967-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11967-MONOMER COG COG1256 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1256 DIP DIP-9639N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9639N DOI 10.1006/jmbi.1994.1279 http://dx.doi.org/10.1006/jmbi.1994.1279 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U02514 http://www.ebi.ac.uk/ena/data/view/U02514 EchoBASE EB1910 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1910 EcoGene EG11967 http://www.ecogene.org/geneInfo.php?eg_id=EG11967 EnsemblBacteria AAC74166 http://www.ensemblgenomes.org/id/AAC74166 EnsemblBacteria AAC74166 http://www.ensemblgenomes.org/id/AAC74166 EnsemblBacteria BAA35891 http://www.ensemblgenomes.org/id/BAA35891 EnsemblBacteria BAA35891 http://www.ensemblgenomes.org/id/BAA35891 EnsemblBacteria BAA35891 http://www.ensemblgenomes.org/id/BAA35891 EnsemblBacteria b1082 http://www.ensemblgenomes.org/id/b1082 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005576 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576 GO_component GO:0009424 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009424 GO_function GO:0005198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005198 GO_process GO:0044780 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044780 GO_process GO:0071973 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071973 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005576 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576 GOslim_function GO:0005198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005198 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 GeneID 945648 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945648 HOGENOM HOG000265598 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000265598&db=HOGENOM6 InParanoid P33235 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33235 IntAct P33235 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33235* InterPro IPR001444 http://www.ebi.ac.uk/interpro/entry/IPR001444 InterPro IPR002371 http://www.ebi.ac.uk/interpro/entry/IPR002371 InterPro IPR010930 http://www.ebi.ac.uk/interpro/entry/IPR010930 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW1069 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1069 KEGG_Gene eco:b1082 http://www.genome.jp/dbget-bin/www_bget?eco:b1082 KEGG_Orthology KO:K02396 http://www.genome.jp/dbget-bin/www_bget?KO:K02396 KEGG_Pathway ko02040 http://www.genome.jp/kegg-bin/show_pathway?ko02040 MINT MINT-1322777 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1322777 OMA FQQYYMA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FQQYYMA PRINTS PR01005 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01005 PSORT swissprot:FLGK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLGK_ECOLI PSORT-B swissprot:FLGK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLGK_ECOLI PSORT2 swissprot:FLGK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLGK_ECOLI Pfam PF00460 http://pfam.xfam.org/family/PF00460 Pfam PF06429 http://pfam.xfam.org/family/PF06429 Phobius swissprot:FLGK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLGK_ECOLI PhylomeDB P33235 http://phylomedb.org/?seqid=P33235 ProteinModelPortal P33235 http://www.proteinmodelportal.org/query/uniprot/P33235 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8158647 http://www.ncbi.nlm.nih.gov/pubmed/8158647 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415600 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415600 RefSeq WP_000096479 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000096479 SMR P33235 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33235 STRING 511145.b1082 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1082&targetmode=cogs STRING COG1256 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1256&targetmode=cogs TIGRFAMs TIGR02492 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02492 UniProtKB FLGK_ECOLI http://www.uniprot.org/uniprot/FLGK_ECOLI UniProtKB-AC P33235 http://www.uniprot.org/uniprot/P33235 charge swissprot:FLGK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLGK_ECOLI eggNOG COG1256 http://eggnogapi.embl.de/nog_data/html/tree/COG1256 eggNOG ENOG4105E1Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E1Q epestfind swissprot:FLGK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLGK_ECOLI garnier swissprot:FLGK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLGK_ECOLI helixturnhelix swissprot:FLGK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLGK_ECOLI hmoment swissprot:FLGK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLGK_ECOLI iep swissprot:FLGK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLGK_ECOLI inforesidue swissprot:FLGK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLGK_ECOLI octanol swissprot:FLGK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLGK_ECOLI pepcoil swissprot:FLGK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLGK_ECOLI pepdigest swissprot:FLGK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLGK_ECOLI pepinfo swissprot:FLGK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLGK_ECOLI pepnet swissprot:FLGK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLGK_ECOLI pepstats swissprot:FLGK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLGK_ECOLI pepwheel swissprot:FLGK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLGK_ECOLI pepwindow swissprot:FLGK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLGK_ECOLI sigcleave swissprot:FLGK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLGK_ECOLI ## Database ID URL or Descriptions # AltName Cell division protein FtsW {ECO:0000255|HAMAP-Rule MF_00913} # BioGrid 4261096 481 # DOMAIN FTSW_ECOLI The periplasmic loop between transmembrane domains 7 and 8 is essential for activity and the loop between transmembrane domains 9 and 10 is involved in the recruitment of FtsI at the division site. {ECO 0000269|PubMed 15576787}. # EcoGene EG10344 ftsW # FUNCTION FTSW_ECOLI Essential cell division protein. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. Required for localization of FtsI. May play a role in the stabilization of the FtsZ ring during cell division. {ECO 0000255|HAMAP-Rule MF_00913, ECO 0000269|PubMed 21386816, ECO 0000269|PubMed 24711460, ECO 0000269|PubMed 9218774}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0032153 cell division site; IDA:EcoliWiki. # GO_function GO:0015648 lipid-linked peptidoglycan transporter activity; IDA:EcoCyc. # GO_process GO:0008360 regulation of cell shape; IMP:EcoliWiki. # GO_process GO:0009252 peptidoglycan biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0043093 FtsZ-dependent cytokinesis; IEA:UniProtKB-HAMAP. # GO_process GO:0051301 cell division; IMP:EcoliWiki. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0051301 cell division # GOslim_process GO:0071554 cell wall organization or biogenesis # HAMAP MF_00913 FtsW_proteobact # INTERACTION FTSW_ECOLI P0AD68 ftsI; NbExp=7; IntAct=EBI-1214767, EBI-548564; P29131 ftsN; NbExp=3; IntAct=EBI-1214767, EBI-1134233; P06136 ftsQ; NbExp=3; IntAct=EBI-1214767, EBI-1130157; # IntAct P0ABG4 10 # InterPro IPR001182 Cell_cycle_FtsW/RodA # InterPro IPR013437 FtsW # InterPro IPR018365 Cell_cycle_FtsW-rel_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko03036 Chromosome # KEGG_Pathway ko04112 Cell cycle - Caulobacter # MISCELLANEOUS FTSW_ECOLI MurJ (AC P0AF16) is also proposed to act as a lipid II flippase. The identity of the lipid II flippase is controversial with conflicting in vivo and in vitro results. # Organism FTSW_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30474 PTHR30474 # PATRIC 32115283 VBIEscCol129921_0093 # PIR A32581 CEECFW # PROSITE PS00428 FTSW_RODA_SPOVE # Pfam PF01098 FTSW_RODA_SPOVE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FTSW_ECOLI Lipid II flippase FtsW # RefSeq NP_414631 NC_000913.3 # RefSeq WP_001295532 NZ_LN832404.1 # SIMILARITY Belongs to the SEDS family. FtsW subfamily. {ECO:0000255|HAMAP-Rule MF_00913}. # SUBCELLULAR LOCATION FTSW_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_00913, ECO 0000269|PubMed 11807049, ECO 0000269|PubMed 12423747, ECO 0000269|PubMed 9603865}; Multi- pass membrane protein {ECO 0000255|HAMAP-Rule MF_00913, ECO 0000269|PubMed 11807049, ECO 0000269|PubMed 12423747, ECO 0000269|PubMed 9603865}. Note=Localizes to the division septum. Localization requires FtsZ, FtsA, FtsQ and FtsL, but not FtsI. # SUBUNIT FTSW_ECOLI Forms a complex with FtsI. Interacts also with FtsL, FtsQ and FtsN. {ECO 0000269|PubMed 15774864, ECO 0000269|PubMed 17185541, ECO 0000269|PubMed 20497333, ECO 0000269|PubMed 20847002}. # TCDB 2.A.103.1 the bacterial murein precursor exporter (mpe) family # TIGRFAMs TIGR02614 ftsW # eggNOG COG0772 LUCA # eggNOG ENOG4105CNI Bacteria BLAST swissprot:FTSW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FTSW_ECOLI BioCyc ECOL316407:JW0087-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0087-MONOMER BioCyc EcoCyc:EG10344-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10344-MONOMER BioCyc MetaCyc:EG10344-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10344-MONOMER COG COG0772 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0772 DIP DIP-47989N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47989N DOI 10.1038/emboj.2011.61 http://dx.doi.org/10.1038/emboj.2011.61 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1997.4091773.x http://dx.doi.org/10.1046/j.1365-2958.1997.4091773.x DOI 10.1074/jbc.M114.557371 http://dx.doi.org/10.1074/jbc.M114.557371 DOI 10.1093/nar/18.13.4014 http://dx.doi.org/10.1093/nar/18.13.4014 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1099/mic.0.040071-0 http://dx.doi.org/10.1099/mic.0.040071-0 DOI 10.1099/mic.0.2006/000265-0 http://dx.doi.org/10.1099/mic.0.2006/000265-0 DOI 10.1111/j.1365-2958.2010.07211.x http://dx.doi.org/10.1111/j.1365-2958.2010.07211.x DOI 10.1111/j.1574-6968.2002.tb11409.x http://dx.doi.org/10.1111/j.1574-6968.2002.tb11409.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.186.24.8370-8379.2004 http://dx.doi.org/10.1128/JB.186.24.8370-8379.2004 DOI 10.1128/JB.187.7.2233-2243.2005 http://dx.doi.org/10.1128/JB.187.7.2233-2243.2005 DOI 10.1128/jb.184.4.904-912.2002 http://dx.doi.org/10.1128/jb.184.4.904-912.2002 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M30807 http://www.ebi.ac.uk/ena/data/view/M30807 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X52644 http://www.ebi.ac.uk/ena/data/view/X52644 EMBL X55034 http://www.ebi.ac.uk/ena/data/view/X55034 EchoBASE EB0340 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0340 EcoGene EG10344 http://www.ecogene.org/geneInfo.php?eg_id=EG10344 EnsemblBacteria AAC73200 http://www.ensemblgenomes.org/id/AAC73200 EnsemblBacteria AAC73200 http://www.ensemblgenomes.org/id/AAC73200 EnsemblBacteria BAB96657 http://www.ensemblgenomes.org/id/BAB96657 EnsemblBacteria BAB96657 http://www.ensemblgenomes.org/id/BAB96657 EnsemblBacteria BAB96657 http://www.ensemblgenomes.org/id/BAB96657 EnsemblBacteria b0089 http://www.ensemblgenomes.org/id/b0089 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0032153 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032153 GO_function GO:0015648 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015648 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0009252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009252 GO_process GO:0043093 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043093 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 GeneID 946322 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946322 HAMAP MF_00913 http://hamap.expasy.org/unirule/MF_00913 HOGENOM HOG000282689 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000282689&db=HOGENOM6 InParanoid P0ABG4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABG4 IntAct P0ABG4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABG4* InterPro IPR001182 http://www.ebi.ac.uk/interpro/entry/IPR001182 InterPro IPR013437 http://www.ebi.ac.uk/interpro/entry/IPR013437 InterPro IPR018365 http://www.ebi.ac.uk/interpro/entry/IPR018365 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene ecj:JW0087 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0087 KEGG_Gene eco:b0089 http://www.genome.jp/dbget-bin/www_bget?eco:b0089 KEGG_Orthology KO:K03588 http://www.genome.jp/dbget-bin/www_bget?KO:K03588 KEGG_Pathway ko04112 http://www.genome.jp/kegg-bin/show_pathway?ko04112 OMA VMYDRTL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VMYDRTL PANTHER PTHR30474 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30474 PROSITE PS00428 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00428 PSORT swissprot:FTSW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FTSW_ECOLI PSORT-B swissprot:FTSW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FTSW_ECOLI PSORT2 swissprot:FTSW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FTSW_ECOLI Pfam PF01098 http://pfam.xfam.org/family/PF01098 Phobius swissprot:FTSW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FTSW_ECOLI PhylomeDB P0ABG4 http://phylomedb.org/?seqid=P0ABG4 ProteinModelPortal P0ABG4 http://www.proteinmodelportal.org/query/uniprot/P0ABG4 PubMed 11807049 http://www.ncbi.nlm.nih.gov/pubmed/11807049 PubMed 12423747 http://www.ncbi.nlm.nih.gov/pubmed/12423747 PubMed 15576787 http://www.ncbi.nlm.nih.gov/pubmed/15576787 PubMed 15774864 http://www.ncbi.nlm.nih.gov/pubmed/15774864 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17185541 http://www.ncbi.nlm.nih.gov/pubmed/17185541 PubMed 20497333 http://www.ncbi.nlm.nih.gov/pubmed/20497333 PubMed 20847002 http://www.ncbi.nlm.nih.gov/pubmed/20847002 PubMed 21386816 http://www.ncbi.nlm.nih.gov/pubmed/21386816 PubMed 2197603 http://www.ncbi.nlm.nih.gov/pubmed/2197603 PubMed 24711460 http://www.ncbi.nlm.nih.gov/pubmed/24711460 PubMed 2509435 http://www.ncbi.nlm.nih.gov/pubmed/2509435 PubMed 7961485 http://www.ncbi.nlm.nih.gov/pubmed/7961485 PubMed 9006034 http://www.ncbi.nlm.nih.gov/pubmed/9006034 PubMed 9218774 http://www.ncbi.nlm.nih.gov/pubmed/9218774 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9603865 http://www.ncbi.nlm.nih.gov/pubmed/9603865 RefSeq NP_414631 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414631 RefSeq WP_001295532 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295532 STRING 511145.b0089 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0089&targetmode=cogs STRING COG0772 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0772&targetmode=cogs TCDB 2.A.103.1 http://www.tcdb.org/search/result.php?tc=2.A.103.1 TIGRFAMs TIGR02614 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02614 UniProtKB FTSW_ECOLI http://www.uniprot.org/uniprot/FTSW_ECOLI UniProtKB-AC P0ABG4 http://www.uniprot.org/uniprot/P0ABG4 charge swissprot:FTSW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FTSW_ECOLI eggNOG COG0772 http://eggnogapi.embl.de/nog_data/html/tree/COG0772 eggNOG ENOG4105CNI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CNI epestfind swissprot:FTSW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FTSW_ECOLI garnier swissprot:FTSW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FTSW_ECOLI helixturnhelix swissprot:FTSW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FTSW_ECOLI hmoment swissprot:FTSW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FTSW_ECOLI iep swissprot:FTSW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FTSW_ECOLI inforesidue swissprot:FTSW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FTSW_ECOLI octanol swissprot:FTSW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FTSW_ECOLI pepcoil swissprot:FTSW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FTSW_ECOLI pepdigest swissprot:FTSW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FTSW_ECOLI pepinfo swissprot:FTSW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FTSW_ECOLI pepnet swissprot:FTSW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FTSW_ECOLI pepstats swissprot:FTSW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FTSW_ECOLI pepwheel swissprot:FTSW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FTSW_ECOLI pepwindow swissprot:FTSW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FTSW_ECOLI sigcleave swissprot:FTSW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FTSW_ECOLI ## Database ID URL or Descriptions # COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI 29105; Note=Binds 1 zinc ion.; # EcoGene EG12314 yacG # FUNCTION YACG_ECOLI Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase. {ECO 0000255|HAMAP-Rule MF_00649, ECO 0000269|PubMed 18586829}. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_function GO:0008657 DNA topoisomerase (ATP-hydrolyzing) inhibitor activity; IDA:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:InterPro. # GOslim_function GO:0030234 enzyme regulator activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # Gene3D 3.30.50.10 -; 1. # HAMAP MF_00649 DNA_gyrase_inhibitor_YacG # IntAct P0A8H8 3 # InterPro IPR005584 DNA_gyrase_inhibitor_YacG # InterPro IPR013088 Znf_NHR/GATA # Organism YACG_ECOLI Escherichia coli (strain K12) # PATRIC 32115305 VBIEscCol129921_0104 # PDB 1LV3 NMR; -; A=1-65 # PDB 4TMA X-ray; 3.30 A; I/J/K/L=1-65 # PIR E64732 E64732 # Pfam PF03884 DUF329 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DNA gyrase inhibitor YacG {ECO:0000255|HAMAP-Rule MF_00649} # RefSeq NP_414643 NC_000913.3 # RefSeq WP_000005042 NZ_LN832404.1 # SIMILARITY Belongs to the DNA gyrase inhibitor YacG family. {ECO:0000255|HAMAP-Rule MF_00649}. # SUBUNIT YACG_ECOLI Interacts with GyrB. {ECO 0000255|HAMAP-Rule MF_00649, ECO 0000269|PubMed 18586829}. # eggNOG COG3024 LUCA # eggNOG ENOG41067SF Bacteria BLAST swissprot:YACG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YACG_ECOLI BioCyc ECOL316407:JW5008-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5008-MONOMER BioCyc EcoCyc:EG12314-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12314-MONOMER COG COG3024 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3024 DIP DIP-48126N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48126N DOI 10.1002/prot.10214 http://dx.doi.org/10.1002/prot.10214 DOI 10.1007/BF00326530 http://dx.doi.org/10.1007/BF00326530 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1093/nar/gkn355 http://dx.doi.org/10.1093/nar/gkn355 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X04831 http://www.ebi.ac.uk/ena/data/view/X04831 EchoBASE EB2220 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2220 EcoGene EG12314 http://www.ecogene.org/geneInfo.php?eg_id=EG12314 EnsemblBacteria AAC73212 http://www.ensemblgenomes.org/id/AAC73212 EnsemblBacteria AAC73212 http://www.ensemblgenomes.org/id/AAC73212 EnsemblBacteria BAB96668 http://www.ensemblgenomes.org/id/BAB96668 EnsemblBacteria BAB96668 http://www.ensemblgenomes.org/id/BAB96668 EnsemblBacteria BAB96668 http://www.ensemblgenomes.org/id/BAB96668 EnsemblBacteria b0101 http://www.ensemblgenomes.org/id/b0101 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0008657 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008657 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.30.50.10 http://www.cathdb.info/version/latest/superfamily/3.30.50.10 GeneID 945630 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945630 HAMAP MF_00649 http://hamap.expasy.org/unirule/MF_00649 HOGENOM HOG000255917 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000255917&db=HOGENOM6 InParanoid P0A8H8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8H8 IntAct P0A8H8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8H8* InterPro IPR005584 http://www.ebi.ac.uk/interpro/entry/IPR005584 InterPro IPR013088 http://www.ebi.ac.uk/interpro/entry/IPR013088 KEGG_Gene ecj:JW5008 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5008 KEGG_Gene eco:b0101 http://www.genome.jp/dbget-bin/www_bget?eco:b0101 KEGG_Orthology KO:K09862 http://www.genome.jp/dbget-bin/www_bget?KO:K09862 MINT MINT-1228215 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1228215 OMA TIVKCPQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TIVKCPQ PDB 1LV3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1LV3 PDB 4TMA http://www.ebi.ac.uk/pdbe-srv/view/entry/4TMA PDBsum 1LV3 http://www.ebi.ac.uk/pdbsum/1LV3 PDBsum 4TMA http://www.ebi.ac.uk/pdbsum/4TMA PSORT swissprot:YACG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YACG_ECOLI PSORT-B swissprot:YACG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YACG_ECOLI PSORT2 swissprot:YACG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YACG_ECOLI Pfam PF03884 http://pfam.xfam.org/family/PF03884 Phobius swissprot:YACG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YACG_ECOLI PhylomeDB P0A8H8 http://phylomedb.org/?seqid=P0A8H8 ProteinModelPortal P0A8H8 http://www.proteinmodelportal.org/query/uniprot/P0A8H8 PubMed 12211008 http://www.ncbi.nlm.nih.gov/pubmed/12211008 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18586829 http://www.ncbi.nlm.nih.gov/pubmed/18586829 PubMed 3033442 http://www.ncbi.nlm.nih.gov/pubmed/3033442 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414643 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414643 RefSeq WP_000005042 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000005042 SMR P0A8H8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8H8 STRING 511145.b0101 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0101&targetmode=cogs STRING COG3024 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3024&targetmode=cogs UniProtKB YACG_ECOLI http://www.uniprot.org/uniprot/YACG_ECOLI UniProtKB-AC P0A8H8 http://www.uniprot.org/uniprot/P0A8H8 charge swissprot:YACG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YACG_ECOLI eggNOG COG3024 http://eggnogapi.embl.de/nog_data/html/tree/COG3024 eggNOG ENOG41067SF http://eggnogapi.embl.de/nog_data/html/tree/ENOG41067SF epestfind swissprot:YACG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YACG_ECOLI garnier swissprot:YACG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YACG_ECOLI helixturnhelix swissprot:YACG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YACG_ECOLI hmoment swissprot:YACG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YACG_ECOLI iep swissprot:YACG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YACG_ECOLI inforesidue swissprot:YACG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YACG_ECOLI octanol swissprot:YACG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YACG_ECOLI pepcoil swissprot:YACG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YACG_ECOLI pepdigest swissprot:YACG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YACG_ECOLI pepinfo swissprot:YACG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YACG_ECOLI pepnet swissprot:YACG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YACG_ECOLI pepstats swissprot:YACG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YACG_ECOLI pepwheel swissprot:YACG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YACG_ECOLI pepwindow swissprot:YACG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YACG_ECOLI sigcleave swissprot:YACG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YACG_ECOLI ## Database ID URL or Descriptions # BioGrid 4262808 6 # DISRUPTION PHENOTYPE In cells lacking this gene, expression of the bet promoters is stimulated by osmotic stress but not by choline. {ECO:0000269|PubMed 8626294}. # EcoGene EG10111 betI # FUNCTION BETI_ECOLI Repressor involved in the biosynthesis of the osmoprotectant glycine betaine. It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine. {ECO 0000269|PubMed 8626294, ECO 0000269|PubMed 8626295}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0000976 transcription regulatory region sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IBA:GO_Central. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006970 response to osmotic stress; IEP:EcoCyc. # GO_process GO:0019285 glycine betaine biosynthetic process from choline; IEA:UniProtKB-HAMAP. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IEP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.357.10 -; 1. # HAMAP MF_00768 HTH_type_BetI # INDUCTION Negatively autoregulated. {ECO:0000269|PubMed 8626295}. # IntAct P17446 10 # InterPro IPR001647 HTH_TetR # InterPro IPR009057 Homeodomain-like # InterPro IPR011075 Tet_transcr_reg_TetR-rel_C # InterPro IPR015893 Tet_transcr_reg_TetR-like_C # InterPro IPR017757 Tscrpt_rep_BetI # InterPro IPR023772 DNA-bd_HTH_TetR-type_CS # KEGG_Brite ko03000 Transcription factors # MISCELLANEOUS BetI is an unusual repressor because it remains bound to DNA during induction. {ECO:0000305|PubMed 8626295}. # Organism BETI_ECOLI Escherichia coli (strain K12) # PATHWAY BETI_ECOLI Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway [regulation]. # PATRIC 32115755 VBIEscCol129921_0320 # PIR S15180 S10899 # PRINTS PR00455 HTHTETR # PROSITE PS01081 HTH_TETR_1 # PROSITE PS50977 HTH_TETR_2 # Pfam PF00440 TetR_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HTH-type transcriptional regulator BetI {ECO:0000255|HAMAP-Rule MF_00768} # RefSeq NP_414847 NC_000913.3 # RefSeq WP_001335745 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18039.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Contains 1 HTH tetR-type DNA-binding domain. {ECO:0000255|HAMAP-Rule MF_00768}. # SUPFAM SSF46689 SSF46689 # SUPFAM SSF48498 SSF48498 # TIGRFAMs TIGR03384 betaine_BetI # eggNOG COG1309 LUCA # eggNOG ENOG4108MHR Bacteria BLAST swissprot:BETI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BETI_ECOLI BioCyc ECOL316407:JW0305-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0305-MONOMER BioCyc EcoCyc:PD00251 http://biocyc.org/getid?id=EcoCyc:PD00251 COG COG1309 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1309 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1991.tb01877.x http://dx.doi.org/10.1111/j.1365-2958.1991.tb01877.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EMBL X52905 http://www.ebi.ac.uk/ena/data/view/X52905 EchoBASE EB0109 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0109 EcoGene EG10111 http://www.ecogene.org/geneInfo.php?eg_id=EG10111 EnsemblBacteria AAC73416 http://www.ensemblgenomes.org/id/AAC73416 EnsemblBacteria AAC73416 http://www.ensemblgenomes.org/id/AAC73416 EnsemblBacteria BAE76096 http://www.ensemblgenomes.org/id/BAE76096 EnsemblBacteria BAE76096 http://www.ensemblgenomes.org/id/BAE76096 EnsemblBacteria BAE76096 http://www.ensemblgenomes.org/id/BAE76096 EnsemblBacteria b0313 http://www.ensemblgenomes.org/id/b0313 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000976 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000976 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006970 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006970 GO_process GO:0019285 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019285 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.357.10 http://www.cathdb.info/version/latest/superfamily/1.10.357.10 GeneID 944981 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944981 HAMAP MF_00768 http://hamap.expasy.org/unirule/MF_00768 HOGENOM HOG000248227 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000248227&db=HOGENOM6 InParanoid P17446 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P17446 IntAct P17446 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P17446* InterPro IPR001647 http://www.ebi.ac.uk/interpro/entry/IPR001647 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR011075 http://www.ebi.ac.uk/interpro/entry/IPR011075 InterPro IPR015893 http://www.ebi.ac.uk/interpro/entry/IPR015893 InterPro IPR017757 http://www.ebi.ac.uk/interpro/entry/IPR017757 InterPro IPR023772 http://www.ebi.ac.uk/interpro/entry/IPR023772 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW0305 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0305 KEGG_Gene eco:b0313 http://www.genome.jp/dbget-bin/www_bget?eco:b0313 KEGG_Orthology KO:K02167 http://www.genome.jp/dbget-bin/www_bget?KO:K02167 OMA LVSEFHR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LVSEFHR PRINTS PR00455 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00455 PROSITE PS01081 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01081 PROSITE PS50977 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50977 PSORT swissprot:BETI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BETI_ECOLI PSORT-B swissprot:BETI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BETI_ECOLI PSORT2 swissprot:BETI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BETI_ECOLI Pfam PF00440 http://pfam.xfam.org/family/PF00440 Phobius swissprot:BETI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BETI_ECOLI PhylomeDB P17446 http://phylomedb.org/?seqid=P17446 ProteinModelPortal P17446 http://www.proteinmodelportal.org/query/uniprot/P17446 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1956285 http://www.ncbi.nlm.nih.gov/pubmed/1956285 PubMed 8626294 http://www.ncbi.nlm.nih.gov/pubmed/8626294 PubMed 8626295 http://www.ncbi.nlm.nih.gov/pubmed/8626295 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414847 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414847 RefSeq WP_001335745 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001335745 SMR P17446 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P17446 STRING 511145.b0313 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0313&targetmode=cogs STRING COG1309 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1309&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF48498 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48498 TIGRFAMs TIGR03384 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03384 UniProtKB BETI_ECOLI http://www.uniprot.org/uniprot/BETI_ECOLI UniProtKB-AC P17446 http://www.uniprot.org/uniprot/P17446 charge swissprot:BETI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BETI_ECOLI eggNOG COG1309 http://eggnogapi.embl.de/nog_data/html/tree/COG1309 eggNOG ENOG4108MHR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MHR epestfind swissprot:BETI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BETI_ECOLI garnier swissprot:BETI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BETI_ECOLI helixturnhelix swissprot:BETI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BETI_ECOLI hmoment swissprot:BETI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BETI_ECOLI iep swissprot:BETI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BETI_ECOLI inforesidue swissprot:BETI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BETI_ECOLI octanol swissprot:BETI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BETI_ECOLI pepcoil swissprot:BETI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BETI_ECOLI pepdigest swissprot:BETI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BETI_ECOLI pepinfo swissprot:BETI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BETI_ECOLI pepnet swissprot:BETI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BETI_ECOLI pepstats swissprot:BETI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BETI_ECOLI pepwheel swissprot:BETI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BETI_ECOLI pepwindow swissprot:BETI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BETI_ECOLI sigcleave swissprot:BETI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BETI_ECOLI ## Database ID URL or Descriptions # BioGrid 4261002 127 # EcoGene EG12565 yjiD # FUNCTION IRAD_ECOLI Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during oxidative stress. Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway. {ECO 0000269|PubMed 18383615}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0043856 anti-sigma factor antagonist activity; IDA:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoCyc. # GO_process GO:0042177 negative regulation of protein catabolic process; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0000988 transcription factor activity, protein binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # HAMAP MF_02010 IraD # INDUCTION By oxidative stress. {ECO:0000269|PubMed 11443091}. # InterPro IPR007048 GpW/Gp25/IraD # InterPro IPR023776 Anti-adapt_IraD # Organism IRAD_ECOLI Escherichia coli (strain K12) # PATRIC 32124254 VBIEscCol129921_4470 # PIR S56551 S56551 # Pfam PF04965 GPW_gp25 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName IRAD_ECOLI Anti-adapter protein IraD # RefSeq NP_418746 NC_000913.3 # RefSeq WP_001309187 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97222.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the GpW/Gp25 family. IraD subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION IRAD_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Interacts with RssB. {ECO:0000269|PubMed 18383615}. # eggNOG ENOG4106PZD Bacteria # eggNOG ENOG410YG2Q LUCA BLAST swissprot:IRAD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:IRAD_ECOLI BioCyc ECOL316407:JW5782-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5782-MONOMER BioCyc EcoCyc:G7923-MONOMER http://biocyc.org/getid?id=EcoCyc:G7923-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1111/j.1365-2958.2004.04125.x http://dx.doi.org/10.1111/j.1365-2958.2004.04125.x DOI 10.1111/j.1365-2958.2008.06146.x http://dx.doi.org/10.1111/j.1365-2958.2008.06146.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.183.15.4562-4570.2001 http://dx.doi.org/10.1128/JB.183.15.4562-4570.2001 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2453 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2453 EcoGene EG12565 http://www.ecogene.org/geneInfo.php?eg_id=EG12565 EnsemblBacteria AAC77282 http://www.ensemblgenomes.org/id/AAC77282 EnsemblBacteria AAC77282 http://www.ensemblgenomes.org/id/AAC77282 EnsemblBacteria BAE78319 http://www.ensemblgenomes.org/id/BAE78319 EnsemblBacteria BAE78319 http://www.ensemblgenomes.org/id/BAE78319 EnsemblBacteria BAE78319 http://www.ensemblgenomes.org/id/BAE78319 EnsemblBacteria b4326 http://www.ensemblgenomes.org/id/b4326 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0043856 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043856 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0042177 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042177 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0000988 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000988 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 948851 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948851 HAMAP MF_02010 http://hamap.expasy.org/unirule/MF_02010 HOGENOM HOG000050876 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000050876&db=HOGENOM6 IntAct P39375 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39375* InterPro IPR007048 http://www.ebi.ac.uk/interpro/entry/IPR007048 InterPro IPR023776 http://www.ebi.ac.uk/interpro/entry/IPR023776 KEGG_Gene ecj:JW5782 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5782 KEGG_Gene eco:b4326 http://www.genome.jp/dbget-bin/www_bget?eco:b4326 OMA FKEAYCH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FKEAYCH PSORT swissprot:IRAD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:IRAD_ECOLI PSORT-B swissprot:IRAD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:IRAD_ECOLI PSORT2 swissprot:IRAD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:IRAD_ECOLI Pfam PF04965 http://pfam.xfam.org/family/PF04965 Phobius swissprot:IRAD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:IRAD_ECOLI ProteinModelPortal P39375 http://www.proteinmodelportal.org/query/uniprot/P39375 PubMed 11443091 http://www.ncbi.nlm.nih.gov/pubmed/11443091 PubMed 15225322 http://www.ncbi.nlm.nih.gov/pubmed/15225322 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18383615 http://www.ncbi.nlm.nih.gov/pubmed/18383615 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418746 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418746 RefSeq WP_001309187 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001309187 STRING 511145.b4326 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4326&targetmode=cogs UniProtKB IRAD_ECOLI http://www.uniprot.org/uniprot/IRAD_ECOLI UniProtKB-AC P39375 http://www.uniprot.org/uniprot/P39375 charge swissprot:IRAD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:IRAD_ECOLI eggNOG ENOG4106PZD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106PZD eggNOG ENOG410YG2Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YG2Q epestfind swissprot:IRAD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:IRAD_ECOLI garnier swissprot:IRAD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:IRAD_ECOLI helixturnhelix swissprot:IRAD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:IRAD_ECOLI hmoment swissprot:IRAD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:IRAD_ECOLI iep swissprot:IRAD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:IRAD_ECOLI inforesidue swissprot:IRAD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:IRAD_ECOLI octanol swissprot:IRAD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:IRAD_ECOLI pepcoil swissprot:IRAD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:IRAD_ECOLI pepdigest swissprot:IRAD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:IRAD_ECOLI pepinfo swissprot:IRAD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:IRAD_ECOLI pepnet swissprot:IRAD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:IRAD_ECOLI pepstats swissprot:IRAD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:IRAD_ECOLI pepwheel swissprot:IRAD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:IRAD_ECOLI pepwindow swissprot:IRAD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:IRAD_ECOLI sigcleave swissprot:IRAD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:IRAD_ECOLI ## Database ID URL or Descriptions # AltName DNA-(apurinic or apyrimidinic site) lyase {ECO:0000255|HAMAP-Rule MF_00942} # BioGrid 4262186 123 # CATALYTIC ACTIVITY END3_ECOLI The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. {ECO 0000255|HAMAP-Rule MF_00942, ECO 0000269|PubMed 2449657}. # CDD cd00056 ENDO3c # COFACTOR END3_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000255|HAMAP-Rule MF_00942, ECO 0000269|PubMed 7664751, ECO 0000269|PubMed 8092678}; Note=Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in DNA-binding and proper positioning of the enzyme along the DNA strand. {ECO 0000255|HAMAP-Rule MF_00942, ECO 0000269|PubMed 7664751, ECO 0000269|PubMed 8092678}; # EcoGene EG10662 nth # FUNCTION END3_ECOLI DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. {ECO 0000255|HAMAP-Rule MF_00942, ECO 0000269|PubMed 2449657, ECO 0000269|PubMed 2669955, ECO 0000269|PubMed 6371006}. # GO_function GO:0000703 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity; IDA:EcoCyc. # GO_function GO:0019104 DNA N-glycosylase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IDA:EcoCyc. # GO_process GO:0006285 base-excision repair, AP site formation; IDA:EcoCyc. # GO_process GO:0034644 cellular response to UV; IDA:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004518 nuclease activity # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0008150 biological_process # Gene3D 1.10.1670.10 -; 1. # Gene3D 1.10.340.30 -; 1. # HAMAP MF_00942 Nth # INTERACTION END3_ECOLI P0AFG8 aceE; NbExp=2; IntAct=EBI-555213, EBI-542683; # IntAct P0AB83 6 # InterPro IPR000445 HhH_motif # InterPro IPR003265 HhH-GPD_domain # InterPro IPR003651 Endouclease3_FeS-loop_motif # InterPro IPR004035 Endouclease-III_FeS-bd_BS # InterPro IPR004036 Endonuclease-III-like_CS2 # InterPro IPR005759 Nth # InterPro IPR011257 DNA_glycosylase # InterPro IPR023170 HTH_base_excis_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko03410 Base excision repair # Organism END3_ECOLI Escherichia coli (strain K12) # PATRIC 32118568 VBIEscCol129921_1704 # PDB 2ABK X-ray; 1.85 A; A=1-211 # PIR A32412 A32412 # PIRSF PIRSF001435 Nth # PROSITE PS00764 ENDONUCLEASE_III_1 # PROSITE PS01155 ENDONUCLEASE_III_2 # Pfam PF00633 HHH # Pfam PF00730 HhH-GPD # Pfam PF10576 EndIII_4Fe-2S # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Endonuclease III {ECO:0000255|HAMAP-Rule MF_00942} # RefSeq NP_416150 NC_000913.3 # RefSeq WP_001030339 NZ_LN832404.1 # SIMILARITY Belongs to the Nth/MutY family. {ECO:0000255|HAMAP- Rule MF_00942}. # SIMILARITY Contains 1 HhH domain. {ECO:0000255|HAMAP- Rule MF_00942}. # SMART SM00478 ENDO3c # SMART SM00525 FES # SUBUNIT Monomer. {ECO:0000269|PubMed 6371006}. # SUPFAM SSF48150 SSF48150 # TIGRFAMs TIGR01083 nth # eggNOG COG0177 LUCA # eggNOG ENOG4105CSM Bacteria BLAST swissprot:END3_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:END3_ECOLI BioCyc ECOL316407:JW1625-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1625-MONOMER BioCyc EcoCyc:EG10662-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10662-MONOMER BioCyc MetaCyc:EG10662-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10662-MONOMER COG COG0177 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0177 DIP DIP-48071N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48071N DOI 10.1021/bi00436a048 http://dx.doi.org/10.1021/bi00436a048 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/16.3.1135 http://dx.doi.org/10.1093/nar/16.3.1135 DOI 10.1111/j.1749-6632.1994.tb52818.x http://dx.doi.org/10.1111/j.1749-6632.1994.tb52818.x DOI 10.1126/science.1411536 http://dx.doi.org/10.1126/science.1411536 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.99.18 {ECO:0000255|HAMAP-Rule:MF_00942} http://www.genome.jp/dbget-bin/www_bget?EC:4.2.99.18 {ECO:0000255|HAMAP-Rule:MF_00942} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J02857 http://www.ebi.ac.uk/ena/data/view/J02857 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 4.2.99.18 {ECO:0000255|HAMAP-Rule:MF_00942} http://enzyme.expasy.org/EC/4.2.99.18 {ECO:0000255|HAMAP-Rule:MF_00942} EchoBASE EB0656 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0656 EcoGene EG10662 http://www.ecogene.org/geneInfo.php?eg_id=EG10662 EnsemblBacteria AAC74705 http://www.ensemblgenomes.org/id/AAC74705 EnsemblBacteria AAC74705 http://www.ensemblgenomes.org/id/AAC74705 EnsemblBacteria BAA15387 http://www.ensemblgenomes.org/id/BAA15387 EnsemblBacteria BAA15387 http://www.ensemblgenomes.org/id/BAA15387 EnsemblBacteria BAA15387 http://www.ensemblgenomes.org/id/BAA15387 EnsemblBacteria b1633 http://www.ensemblgenomes.org/id/b1633 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000703 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000703 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003906 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003906 GO_function GO:0019104 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019104 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0006285 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006285 GO_process GO:0034644 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034644 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.10.1670.10 http://www.cathdb.info/version/latest/superfamily/1.10.1670.10 Gene3D 1.10.340.30 http://www.cathdb.info/version/latest/superfamily/1.10.340.30 GeneID 947122 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947122 HAMAP MF_00942 http://hamap.expasy.org/unirule/MF_00942 HOGENOM HOG000252206 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000252206&db=HOGENOM6 InParanoid P0AB83 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AB83 IntAct P0AB83 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AB83* IntEnz 4.2.99.18 {ECO:0000255|HAMAP-Rule:MF_00942} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.99.18 {ECO:0000255|HAMAP-Rule:MF_00942} InterPro IPR000445 http://www.ebi.ac.uk/interpro/entry/IPR000445 InterPro IPR003265 http://www.ebi.ac.uk/interpro/entry/IPR003265 InterPro IPR003651 http://www.ebi.ac.uk/interpro/entry/IPR003651 InterPro IPR004035 http://www.ebi.ac.uk/interpro/entry/IPR004035 InterPro IPR004036 http://www.ebi.ac.uk/interpro/entry/IPR004036 InterPro IPR005759 http://www.ebi.ac.uk/interpro/entry/IPR005759 InterPro IPR011257 http://www.ebi.ac.uk/interpro/entry/IPR011257 InterPro IPR023170 http://www.ebi.ac.uk/interpro/entry/IPR023170 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW1625 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1625 KEGG_Gene eco:b1633 http://www.genome.jp/dbget-bin/www_bget?eco:b1633 KEGG_Orthology KO:K10773 http://www.genome.jp/dbget-bin/www_bget?KO:K10773 KEGG_Pathway ko03410 http://www.genome.jp/kegg-bin/show_pathway?ko03410 MINT MINT-1223379 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1223379 OMA YVCTARK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YVCTARK PDB 2ABK http://www.ebi.ac.uk/pdbe-srv/view/entry/2ABK PDBsum 2ABK http://www.ebi.ac.uk/pdbsum/2ABK PROSITE PS00764 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00764 PROSITE PS01155 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01155 PSORT swissprot:END3_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:END3_ECOLI PSORT-B swissprot:END3_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:END3_ECOLI PSORT2 swissprot:END3_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:END3_ECOLI Pfam PF00633 http://pfam.xfam.org/family/PF00633 Pfam PF00730 http://pfam.xfam.org/family/PF00730 Pfam PF10576 http://pfam.xfam.org/family/PF10576 Phobius swissprot:END3_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:END3_ECOLI PhylomeDB P0AB83 http://phylomedb.org/?seqid=P0AB83 ProteinModelPortal P0AB83 http://www.proteinmodelportal.org/query/uniprot/P0AB83 PubMed 1411536 http://www.ncbi.nlm.nih.gov/pubmed/1411536 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2449657 http://www.ncbi.nlm.nih.gov/pubmed/2449657 PubMed 2669955 http://www.ncbi.nlm.nih.gov/pubmed/2669955 PubMed 6371006 http://www.ncbi.nlm.nih.gov/pubmed/6371006 PubMed 7664751 http://www.ncbi.nlm.nih.gov/pubmed/7664751 PubMed 8092678 http://www.ncbi.nlm.nih.gov/pubmed/8092678 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416150 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416150 RefSeq WP_001030339 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001030339 SMART SM00478 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00478 SMART SM00525 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00525 SMR P0AB83 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AB83 STRING 511145.b1633 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1633&targetmode=cogs STRING COG0177 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0177&targetmode=cogs SUPFAM SSF48150 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48150 TIGRFAMs TIGR01083 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01083 UniProtKB END3_ECOLI http://www.uniprot.org/uniprot/END3_ECOLI UniProtKB-AC P0AB83 http://www.uniprot.org/uniprot/P0AB83 charge swissprot:END3_ECOLI http://rest.g-language.org/emboss/charge/swissprot:END3_ECOLI eggNOG COG0177 http://eggnogapi.embl.de/nog_data/html/tree/COG0177 eggNOG ENOG4105CSM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CSM epestfind swissprot:END3_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:END3_ECOLI garnier swissprot:END3_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:END3_ECOLI helixturnhelix swissprot:END3_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:END3_ECOLI hmoment swissprot:END3_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:END3_ECOLI iep swissprot:END3_ECOLI http://rest.g-language.org/emboss/iep/swissprot:END3_ECOLI inforesidue swissprot:END3_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:END3_ECOLI octanol swissprot:END3_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:END3_ECOLI pepcoil swissprot:END3_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:END3_ECOLI pepdigest swissprot:END3_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:END3_ECOLI pepinfo swissprot:END3_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:END3_ECOLI pepnet swissprot:END3_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:END3_ECOLI pepstats swissprot:END3_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:END3_ECOLI pepwheel swissprot:END3_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:END3_ECOLI pepwindow swissprot:END3_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:END3_ECOLI sigcleave swissprot:END3_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:END3_ECOLI ## Database ID URL or Descriptions # AltName PFLB_ECOLI Pyruvate formate-lyase 1 # BRENDA 2.3.1.54 2026 # BioGrid 4260835 7 # CATALYTIC ACTIVITY PFLB_ECOLI Acetyl-CoA + formate = CoA + pyruvate. # CDD cd01678 PFL1 # EcoGene EG10701 pflB # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0008861 formate C-acetyltransferase activity; IDA:EcoCyc. # GO_process GO:0006006 glucose metabolic process; IEA:UniProtKB-KW. # GO_process GO:0006567 threonine catabolic process; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # INDUCTION PFLB_ECOLI By pfl-activating enzyme under anaerobic conditions by generation of an organic free radical. Exposure of activated pfl to oxygen resulted in cleavage at the glycine residue harboring its organic radical with loss of the 25 C-terminal AA. # INTERACTION PFLB_ECOLI P0A858 tpiA; NbExp=5; IntAct=EBI-546682, EBI-368978; # IntAct P09373 42 # InterPro IPR001150 Gly_radical # InterPro IPR004184 PFL_dom # InterPro IPR005949 Form_AcTrfase # InterPro IPR019777 Form_AcTrfase_GR_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00620 Pyruvate metabolism # KEGG_Pathway ko00640 Propanoate metabolism # KEGG_Pathway ko00650 Butanoate metabolism # MISCELLANEOUS PFLB_ECOLI Several mechanisms have been proposed based on complexes formed with substrate analogs. After activation by the glycine radical, the cysteine radical, Cys-420, can abstract hydrogen atoms from the other active site cysteine, Cys-419, and from coenzyme A, and it can also transfer hydrogen atoms to product radicals. The other active site cysteine can attack the central carbonyl of pyruvate and covalently bind the product acetyl group. # Organism PFLB_ECOLI Escherichia coli (strain K12) # PATHWAY Fermentation; pyruvate fermentation; formate from pyruvate step 1/1. # PATRIC 32117019 VBIEscCol129921_0934 # PDB 1CM5 X-ray; 2.30 A; A/B=2-760 # PDB 1H16 X-ray; 1.53 A; A=2-760 # PDB 1H17 X-ray; 1.75 A; A=2-760 # PDB 1H18 X-ray; 2.30 A; A/B=2-760 # PDB 1MZO X-ray; 2.70 A; A/B=2-760 # PDB 1QHM X-ray; 2.80 A; A/B=2-625 # PDB 2PFL X-ray; 2.90 A; A/B=2-760 # PDB 3PFL X-ray; 2.60 A; A/B=2-760 # PIR S01788 S01788 # PIRSF PIRSF000379 For_Ac_trans_1 # PROSITE PS00850 GLY_RADICAL_1 # PROSITE PS51149 GLY_RADICAL_2 # PROSITE PS51554 PFL # Pfam PF01228 Gly_radical # Pfam PF02901 PFL-like # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PFLB_ECOLI Formate acetyltransferase 1 # RefSeq NP_415423 NC_000913.3 # RefSeq WP_001292822 NZ_LN832404.1 # SIMILARITY Contains 1 PFL domain. {ECO:0000255|PROSITE- ProRule PRU00887}. # SIMILARITY Contains 1 glycine radical domain. {ECO:0000255|PROSITE-ProRule PRU00493}. # SUBCELLULAR LOCATION PFLB_ECOLI Cytoplasm. # SUBUNIT PFLB_ECOLI Homodimer. # TIGRFAMs TIGR01255 pyr_form_ly_1 # UniPathway UPA00920 UER00891 # eggNOG COG1882 LUCA # eggNOG ENOG4105C6N Bacteria BLAST swissprot:PFLB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PFLB_ECOLI BioCyc ECOL316407:JW0886-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0886-MONOMER BioCyc EcoCyc:PYRUVFORMLY-MONOMER http://biocyc.org/getid?id=EcoCyc:PYRUVFORMLY-MONOMER BioCyc MetaCyc:PYRUVFORMLY-MONOMER http://biocyc.org/getid?id=MetaCyc:PYRUVFORMLY-MONOMER COG COG1882 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1882 DIP DIP-10467N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10467N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150190539 http://dx.doi.org/10.1002/elps.1150190539 DOI 10.1038/13341 http://dx.doi.org/10.1038/13341 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nchembio.495 http://dx.doi.org/10.1038/nchembio.495 DOI 10.1073/pnas.89.3.996 http://dx.doi.org/10.1073/pnas.89.3.996 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1432-1033.1988.tb14356.x http://dx.doi.org/10.1111/j.1432-1033.1988.tb14356.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.54 http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.54 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M26413 http://www.ebi.ac.uk/ena/data/view/M26413 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X08035 http://www.ebi.ac.uk/ena/data/view/X08035 ENZYME 2.3.1.54 http://enzyme.expasy.org/EC/2.3.1.54 EchoBASE EB0695 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0695 EcoGene EG10701 http://www.ecogene.org/geneInfo.php?eg_id=EG10701 EnsemblBacteria AAC73989 http://www.ensemblgenomes.org/id/AAC73989 EnsemblBacteria AAC73989 http://www.ensemblgenomes.org/id/AAC73989 EnsemblBacteria BAA35638 http://www.ensemblgenomes.org/id/BAA35638 EnsemblBacteria BAA35638 http://www.ensemblgenomes.org/id/BAA35638 EnsemblBacteria BAA35638 http://www.ensemblgenomes.org/id/BAA35638 EnsemblBacteria b0903 http://www.ensemblgenomes.org/id/b0903 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0008861 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008861 GO_process GO:0006006 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006006 GO_process GO:0006567 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006567 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 945514 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945514 HOGENOM HOG000011346 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000011346&db=HOGENOM6 InParanoid P09373 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P09373 IntAct P09373 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P09373* IntEnz 2.3.1.54 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.54 InterPro IPR001150 http://www.ebi.ac.uk/interpro/entry/IPR001150 InterPro IPR004184 http://www.ebi.ac.uk/interpro/entry/IPR004184 InterPro IPR005949 http://www.ebi.ac.uk/interpro/entry/IPR005949 InterPro IPR019777 http://www.ebi.ac.uk/interpro/entry/IPR019777 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0886 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0886 KEGG_Gene eco:b0903 http://www.genome.jp/dbget-bin/www_bget?eco:b0903 KEGG_Orthology KO:K00656 http://www.genome.jp/dbget-bin/www_bget?KO:K00656 KEGG_Pathway ko00620 http://www.genome.jp/kegg-bin/show_pathway?ko00620 KEGG_Pathway ko00640 http://www.genome.jp/kegg-bin/show_pathway?ko00640 KEGG_Pathway ko00650 http://www.genome.jp/kegg-bin/show_pathway?ko00650 KEGG_Reaction rn:R00212 http://www.genome.jp/dbget-bin/www_bget?rn:R00212 KEGG_Reaction rn:R06987 http://www.genome.jp/dbget-bin/www_bget?rn:R06987 MINT MINT-1283506 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1283506 OMA KATSALW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KATSALW PDB 1CM5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1CM5 PDB 1H16 http://www.ebi.ac.uk/pdbe-srv/view/entry/1H16 PDB 1H17 http://www.ebi.ac.uk/pdbe-srv/view/entry/1H17 PDB 1H18 http://www.ebi.ac.uk/pdbe-srv/view/entry/1H18 PDB 1MZO http://www.ebi.ac.uk/pdbe-srv/view/entry/1MZO PDB 1QHM http://www.ebi.ac.uk/pdbe-srv/view/entry/1QHM PDB 2PFL http://www.ebi.ac.uk/pdbe-srv/view/entry/2PFL PDB 3PFL http://www.ebi.ac.uk/pdbe-srv/view/entry/3PFL PDBsum 1CM5 http://www.ebi.ac.uk/pdbsum/1CM5 PDBsum 1H16 http://www.ebi.ac.uk/pdbsum/1H16 PDBsum 1H17 http://www.ebi.ac.uk/pdbsum/1H17 PDBsum 1H18 http://www.ebi.ac.uk/pdbsum/1H18 PDBsum 1MZO http://www.ebi.ac.uk/pdbsum/1MZO PDBsum 1QHM http://www.ebi.ac.uk/pdbsum/1QHM PDBsum 2PFL http://www.ebi.ac.uk/pdbsum/2PFL PDBsum 3PFL http://www.ebi.ac.uk/pdbsum/3PFL PROSITE PS00850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00850 PROSITE PS51149 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51149 PROSITE PS51554 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51554 PSORT swissprot:PFLB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PFLB_ECOLI PSORT-B swissprot:PFLB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PFLB_ECOLI PSORT2 swissprot:PFLB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PFLB_ECOLI Pfam PF01228 http://pfam.xfam.org/family/PF01228 Pfam PF02901 http://pfam.xfam.org/family/PF02901 Phobius swissprot:PFLB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PFLB_ECOLI PhylomeDB P09373 http://phylomedb.org/?seqid=P09373 ProteinModelPortal P09373 http://www.proteinmodelportal.org/query/uniprot/P09373 PubMed 10504733 http://www.ncbi.nlm.nih.gov/pubmed/10504733 PubMed 1310545 http://www.ncbi.nlm.nih.gov/pubmed/1310545 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 21151122 http://www.ncbi.nlm.nih.gov/pubmed/21151122 PubMed 2651404 http://www.ncbi.nlm.nih.gov/pubmed/2651404 PubMed 3053170 http://www.ncbi.nlm.nih.gov/pubmed/3053170 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9629924 http://www.ncbi.nlm.nih.gov/pubmed/9629924 RefSeq NP_415423 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415423 RefSeq WP_001292822 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001292822 SMR P09373 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P09373 STRING 511145.b0903 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0903&targetmode=cogs STRING COG1882 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1882&targetmode=cogs SWISS-2DPAGE P09373 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P09373 TIGRFAMs TIGR01255 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01255 UniProtKB PFLB_ECOLI http://www.uniprot.org/uniprot/PFLB_ECOLI UniProtKB-AC P09373 http://www.uniprot.org/uniprot/P09373 charge swissprot:PFLB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PFLB_ECOLI eggNOG COG1882 http://eggnogapi.embl.de/nog_data/html/tree/COG1882 eggNOG ENOG4105C6N http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C6N epestfind swissprot:PFLB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PFLB_ECOLI garnier swissprot:PFLB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PFLB_ECOLI helixturnhelix swissprot:PFLB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PFLB_ECOLI hmoment swissprot:PFLB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PFLB_ECOLI iep swissprot:PFLB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PFLB_ECOLI inforesidue swissprot:PFLB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PFLB_ECOLI octanol swissprot:PFLB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PFLB_ECOLI pepcoil swissprot:PFLB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PFLB_ECOLI pepdigest swissprot:PFLB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PFLB_ECOLI pepinfo swissprot:PFLB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PFLB_ECOLI pepnet swissprot:PFLB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PFLB_ECOLI pepstats swissprot:PFLB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PFLB_ECOLI pepwheel swissprot:PFLB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PFLB_ECOLI pepwindow swissprot:PFLB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PFLB_ECOLI sigcleave swissprot:PFLB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PFLB_ECOLI ## Database ID URL or Descriptions # AltName SSBF_ECOLI Helix-destabilizing protein # FUNCTION SSBF_ECOLI May contribute to the conjugative processing of DNA. It has a functional relationship with Psi (plasmid-mediated sos inhibition) proteins. {ECO 0000269|PubMed 2013585}. # GO_function GO:0003697 single-stranded DNA binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006260 DNA replication; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0009058 biosynthetic process # HAMAP MF_00984 SSB # InterPro IPR000424 Primosome_PriB/ssb # InterPro IPR011344 ssDNA-bd # InterPro IPR012340 NA-bd_OB-fold # Organism SSBF_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10302 PTHR10302 # PIR A20023 DDECF # PROSITE PS50935 SSB # Pfam PF00436 SSB # RecName SSBF_ECOLI Plasmid-derived single-stranded DNA-binding protein # RefSeq NP_061439 NC_002483.1 # RefSeq WP_000290801 NZ_CP014273.1 # SIMILARITY Contains 1 SSB domain. {ECO:0000255|HAMAP- Rule MF_00984}. # SUBUNIT Homotetramer. {ECO:0000255|HAMAP-Rule MF_00984}. # SUPFAM SSF50249 SSF50249 # TIGRFAMs TIGR00621 ssb BLAST swissprot:SSBF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SSBF_ECOLI DOI 10.1073/pnas.80.18.5480 http://dx.doi.org/10.1073/pnas.80.18.5480 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL K00066 http://www.ebi.ac.uk/ena/data/view/K00066 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003697 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003697 GO_process GO:0006260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 1263584 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263584 HAMAP MF_00984 http://hamap.expasy.org/unirule/MF_00984 InterPro IPR000424 http://www.ebi.ac.uk/interpro/entry/IPR000424 InterPro IPR011344 http://www.ebi.ac.uk/interpro/entry/IPR011344 InterPro IPR012340 http://www.ebi.ac.uk/interpro/entry/IPR012340 OMA ANADGKR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ANADGKR PANTHER PTHR10302 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10302 PROSITE PS50935 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50935 PSORT swissprot:SSBF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SSBF_ECOLI PSORT-B swissprot:SSBF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SSBF_ECOLI PSORT2 swissprot:SSBF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SSBF_ECOLI Pfam PF00436 http://pfam.xfam.org/family/PF00436 Phobius swissprot:SSBF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SSBF_ECOLI PhylomeDB P18310 http://phylomedb.org/?seqid=P18310 ProteinModelPortal P18310 http://www.proteinmodelportal.org/query/uniprot/P18310 PubMed 2013585 http://www.ncbi.nlm.nih.gov/pubmed/2013585 PubMed 6351061 http://www.ncbi.nlm.nih.gov/pubmed/6351061 RefSeq NP_061439 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061439 RefSeq WP_000290801 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000290801 SMR P18310 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P18310 SUPFAM SSF50249 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50249 TIGRFAMs TIGR00621 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00621 UniProtKB SSBF_ECOLI http://www.uniprot.org/uniprot/SSBF_ECOLI UniProtKB-AC P18310 http://www.uniprot.org/uniprot/P18310 charge swissprot:SSBF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SSBF_ECOLI epestfind swissprot:SSBF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SSBF_ECOLI garnier swissprot:SSBF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SSBF_ECOLI helixturnhelix swissprot:SSBF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SSBF_ECOLI hmoment swissprot:SSBF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SSBF_ECOLI iep swissprot:SSBF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SSBF_ECOLI inforesidue swissprot:SSBF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SSBF_ECOLI octanol swissprot:SSBF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SSBF_ECOLI pepcoil swissprot:SSBF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SSBF_ECOLI pepdigest swissprot:SSBF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SSBF_ECOLI pepinfo swissprot:SSBF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SSBF_ECOLI pepnet swissprot:SSBF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SSBF_ECOLI pepstats swissprot:SSBF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SSBF_ECOLI pepwheel swissprot:SSBF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SSBF_ECOLI pepwindow swissprot:SSBF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SSBF_ECOLI sigcleave swissprot:SSBF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SSBF_ECOLI ## Database ID URL or Descriptions # BioGrid 4262479 5 # EcoGene EG12908 frlA # FUNCTION FRLA_ECOLI May be involved in fructoselysine transport. {ECO 0000269|PubMed 12147680}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0015179 L-amino acid transmembrane transporter activity; IBA:GO_Central. # GO_function GO:0015297 antiporter activity; IBA:GO_Central. # GO_process GO:0030393 fructoselysine metabolic process; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006520 cellular amino acid metabolic process # InterPro IPR002293 AA/rel_permease1 # Organism FRLA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11785 PTHR11785 # PATHWAY FRLA_ECOLI Carbohydrate metabolism; fructoselysine degradation. # PATRIC 32122174 VBIEscCol129921_3464 # PIR E65131 E65131 # PIRSF PIRSF006060 AA_transporter # Pfam PF13520 AA_permease_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FRLA_ECOLI Putative fructoselysine transporter FrlA # RefSeq NP_417829 NC_000913.3 # RefSeq WP_000535505 NZ_LN832404.1 # SIMILARITY Belongs to the amino acid-polyamine-organocation (APC) superfamily. {ECO 0000305}. # SUBCELLULAR LOCATION FRLA_ECOLI Cell inner membrane {ECO 0000305}; Multi- pass membrane protein {ECO 0000305}. # TCDB 2.A.3.8.17 the amino acid-polyamine-organocation (apc) family # eggNOG COG0531 LUCA # eggNOG ENOG4107QHQ Bacteria BLAST swissprot:FRLA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FRLA_ECOLI BioCyc ECOL316407:JW3333-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3333-MONOMER BioCyc EcoCyc:YHFM-MONOMER http://biocyc.org/getid?id=EcoCyc:YHFM-MONOMER BioCyc MetaCyc:YHFM-MONOMER http://biocyc.org/getid?id=MetaCyc:YHFM-MONOMER COG COG0531 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0531 DIP DIP-12322N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12322N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M200863200 http://dx.doi.org/10.1074/jbc.M200863200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2745 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2745 EcoGene EG12908 http://www.ecogene.org/geneInfo.php?eg_id=EG12908 EnsemblBacteria AAC76395 http://www.ensemblgenomes.org/id/AAC76395 EnsemblBacteria AAC76395 http://www.ensemblgenomes.org/id/AAC76395 EnsemblBacteria BAE77920 http://www.ensemblgenomes.org/id/BAE77920 EnsemblBacteria BAE77920 http://www.ensemblgenomes.org/id/BAE77920 EnsemblBacteria BAE77920 http://www.ensemblgenomes.org/id/BAE77920 EnsemblBacteria b3370 http://www.ensemblgenomes.org/id/b3370 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015179 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015179 GO_function GO:0015297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015297 GO_process GO:0030393 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030393 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GeneID 947878 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947878 HOGENOM HOG000005029 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000005029&db=HOGENOM6 InParanoid P45539 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45539 IntAct P45539 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45539* InterPro IPR002293 http://www.ebi.ac.uk/interpro/entry/IPR002293 KEGG_Gene ecj:JW3333 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3333 KEGG_Gene eco:b3370 http://www.genome.jp/dbget-bin/www_bget?eco:b3370 KEGG_Orthology KO:K03294 http://www.genome.jp/dbget-bin/www_bget?KO:K03294 OMA WPWAWAQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WPWAWAQ PANTHER PTHR11785 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11785 PSORT swissprot:FRLA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FRLA_ECOLI PSORT-B swissprot:FRLA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FRLA_ECOLI PSORT2 swissprot:FRLA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FRLA_ECOLI Pfam PF13520 http://pfam.xfam.org/family/PF13520 Phobius swissprot:FRLA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FRLA_ECOLI PhylomeDB P45539 http://phylomedb.org/?seqid=P45539 ProteinModelPortal P45539 http://www.proteinmodelportal.org/query/uniprot/P45539 PubMed 12147680 http://www.ncbi.nlm.nih.gov/pubmed/12147680 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417829 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417829 RefSeq WP_000535505 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000535505 STRING 511145.b3370 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3370&targetmode=cogs STRING COG0531 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0531&targetmode=cogs TCDB 2.A.3.8.17 http://www.tcdb.org/search/result.php?tc=2.A.3.8.17 UniProtKB FRLA_ECOLI http://www.uniprot.org/uniprot/FRLA_ECOLI UniProtKB-AC P45539 http://www.uniprot.org/uniprot/P45539 charge swissprot:FRLA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FRLA_ECOLI eggNOG COG0531 http://eggnogapi.embl.de/nog_data/html/tree/COG0531 eggNOG ENOG4107QHQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QHQ epestfind swissprot:FRLA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FRLA_ECOLI garnier swissprot:FRLA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FRLA_ECOLI helixturnhelix swissprot:FRLA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FRLA_ECOLI hmoment swissprot:FRLA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FRLA_ECOLI iep swissprot:FRLA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FRLA_ECOLI inforesidue swissprot:FRLA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FRLA_ECOLI octanol swissprot:FRLA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FRLA_ECOLI pepcoil swissprot:FRLA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FRLA_ECOLI pepdigest swissprot:FRLA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FRLA_ECOLI pepinfo swissprot:FRLA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FRLA_ECOLI pepnet swissprot:FRLA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FRLA_ECOLI pepstats swissprot:FRLA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FRLA_ECOLI pepwheel swissprot:FRLA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FRLA_ECOLI pepwindow swissprot:FRLA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FRLA_ECOLI sigcleave swissprot:FRLA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FRLA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259300 97 # CATALYTIC ACTIVITY CoA-(4'-phosphopantetheine) + apo-[acyl- carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl- carrier-protein]. {ECO:0000305|PubMed 10625633}. # EcoGene EG12221 acpT # FUNCTION ACPT_ECOLI May be involved in an alternative pathway for phosphopantetheinyl transfer and holo-ACP synthesis in E.coli. The native apo-protein substrate is unknown. Is able to functionally replace AcpS in vivo but only when expressed at high levels. {ECO 0000269|PubMed 10625633, ECO 0000269|PubMed 8939709}. # GO_function GO:0000287 magnesium ion binding; IEA:InterPro. # GO_function GO:0008897 holo-[acyl-carrier-protein] synthase activity; IDA:EcoliWiki. # GO_process GO:0006633 fatty acid biosynthetic process; IGI:EcoliWiki. # GO_process GO:0018070 peptidyl-serine phosphopantetheinylation; NAS:EcoliWiki. # GO_process GO:0019878 lysine biosynthetic process via aminoadipic acid; IBA:GO_Central. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.90.470.20 -; 2. # InterPro IPR008278 4-PPantetheinyl_Trfase_SF # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00770 Pantothenate and CoA biosynthesis # Organism ACPT_ECOLI Escherichia coli (strain K12) # PATRIC 32122394 VBIEscCol129921_3574 # PIR S47694 S47694 # Pfam PF01648 ACPS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ACPT_ECOLI 4'-phosphopantetheinyl transferase AcpT # RefSeq NP_417932 NC_000913.3 # RefSeq WP_000285774 NZ_LN832404.1 # SIMILARITY Belongs to the P-Pant transferase superfamily. Gsp/Sfp/HetI/AcpT family. {ECO 0000305}. # SUPFAM SSF56214 SSF56214; 2 # eggNOG COG2091 LUCA # eggNOG ENOG4107YAK Bacteria BLAST swissprot:ACPT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ACPT_ECOLI BioCyc ECOL316407:JW3440-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3440-MONOMER BioCyc EcoCyc:EG12221-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12221-MONOMER BioCyc MetaCyc:EG12221-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12221-MONOMER COG COG2091 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2091 DIP DIP-12355N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12355N DOI 10.1016/S1074-5521(96)90181-7 http://dx.doi.org/10.1016/S1074-5521(96)90181-7 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.275.2.959 http://dx.doi.org/10.1074/jbc.275.2.959 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.8.7 {ECO:0000305|PubMed:10625633} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.8.7 {ECO:0000305|PubMed:10625633} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.8.7 {ECO:0000305|PubMed:10625633} http://enzyme.expasy.org/EC/2.7.8.7 {ECO:0000305|PubMed:10625633} EchoBASE EB2135 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2135 EcoGene EG12221 http://www.ecogene.org/geneInfo.php?eg_id=EG12221 EnsemblBacteria AAC76500 http://www.ensemblgenomes.org/id/AAC76500 EnsemblBacteria AAC76500 http://www.ensemblgenomes.org/id/AAC76500 EnsemblBacteria BAE77818 http://www.ensemblgenomes.org/id/BAE77818 EnsemblBacteria BAE77818 http://www.ensemblgenomes.org/id/BAE77818 EnsemblBacteria BAE77818 http://www.ensemblgenomes.org/id/BAE77818 EnsemblBacteria b3475 http://www.ensemblgenomes.org/id/b3475 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0008897 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008897 GO_process GO:0006633 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006633 GO_process GO:0018070 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018070 GO_process GO:0019878 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019878 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.90.470.20 http://www.cathdb.info/version/latest/superfamily/3.90.470.20 GeneID 947979 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947979 HOGENOM HOG000125719 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125719&db=HOGENOM6 InParanoid P37623 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37623 IntAct P37623 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37623* IntEnz 2.7.8.7 {ECO:0000305|PubMed:10625633} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.8.7 {ECO:0000305|PubMed:10625633} InterPro IPR008278 http://www.ebi.ac.uk/interpro/entry/IPR008278 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3440 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3440 KEGG_Gene eco:b3475 http://www.genome.jp/dbget-bin/www_bget?eco:b3475 KEGG_Orthology KO:K06133 http://www.genome.jp/dbget-bin/www_bget?KO:K06133 KEGG_Pathway ko00770 http://www.genome.jp/kegg-bin/show_pathway?ko00770 KEGG_Reaction rn:R01625 http://www.genome.jp/dbget-bin/www_bget?rn:R01625 OMA WQIVSID http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WQIVSID PSORT swissprot:ACPT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ACPT_ECOLI PSORT-B swissprot:ACPT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ACPT_ECOLI PSORT2 swissprot:ACPT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ACPT_ECOLI Pfam PF01648 http://pfam.xfam.org/family/PF01648 Phobius swissprot:ACPT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ACPT_ECOLI PhylomeDB P37623 http://phylomedb.org/?seqid=P37623 ProteinModelPortal P37623 http://www.proteinmodelportal.org/query/uniprot/P37623 PubMed 10625633 http://www.ncbi.nlm.nih.gov/pubmed/10625633 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 8939709 http://www.ncbi.nlm.nih.gov/pubmed/8939709 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417932 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417932 RefSeq WP_000285774 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000285774 SMR P37623 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37623 STRING 511145.b3475 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3475&targetmode=cogs STRING COG2091 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2091&targetmode=cogs SUPFAM SSF56214 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56214 UniProtKB ACPT_ECOLI http://www.uniprot.org/uniprot/ACPT_ECOLI UniProtKB-AC P37623 http://www.uniprot.org/uniprot/P37623 charge swissprot:ACPT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ACPT_ECOLI eggNOG COG2091 http://eggnogapi.embl.de/nog_data/html/tree/COG2091 eggNOG ENOG4107YAK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107YAK epestfind swissprot:ACPT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ACPT_ECOLI garnier swissprot:ACPT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ACPT_ECOLI helixturnhelix swissprot:ACPT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ACPT_ECOLI hmoment swissprot:ACPT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ACPT_ECOLI iep swissprot:ACPT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ACPT_ECOLI inforesidue swissprot:ACPT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ACPT_ECOLI octanol swissprot:ACPT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ACPT_ECOLI pepcoil swissprot:ACPT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ACPT_ECOLI pepdigest swissprot:ACPT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ACPT_ECOLI pepinfo swissprot:ACPT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ACPT_ECOLI pepnet swissprot:ACPT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ACPT_ECOLI pepstats swissprot:ACPT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ACPT_ECOLI pepwheel swissprot:ACPT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ACPT_ECOLI pepwindow swissprot:ACPT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ACPT_ECOLI sigcleave swissprot:ACPT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ACPT_ECOLI ## Database ID URL or Descriptions # EcoGene EG12487 yjfL # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR007140 DUF350 # Organism YJFL_ECOLI Escherichia coli (strain K12) # PATRIC 32123943 VBIEscCol129921_4316 # PIR S56409 S56409 # Pfam PF03994 DUF350; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJFL_ECOLI UPF0719 inner membrane protein YjfL # RefSeq NP_418605 NC_000913.3 # RefSeq WP_000547760 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0719 family. {ECO 0000305}. # SUBCELLULAR LOCATION YJFL_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG COG3766 LUCA # eggNOG ENOG4105Z6B Bacteria BLAST swissprot:YJFL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJFL_ECOLI BioCyc ECOL316407:JW4142-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4142-MONOMER BioCyc EcoCyc:G7849-MONOMER http://biocyc.org/getid?id=EcoCyc:G7849-MONOMER COG COG3766 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3766 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2380 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2380 EcoGene EG12487 http://www.ecogene.org/geneInfo.php?eg_id=EG12487 EnsemblBacteria AAC77141 http://www.ensemblgenomes.org/id/AAC77141 EnsemblBacteria AAC77141 http://www.ensemblgenomes.org/id/AAC77141 EnsemblBacteria BAE78185 http://www.ensemblgenomes.org/id/BAE78185 EnsemblBacteria BAE78185 http://www.ensemblgenomes.org/id/BAE78185 EnsemblBacteria BAE78185 http://www.ensemblgenomes.org/id/BAE78185 EnsemblBacteria b4184 http://www.ensemblgenomes.org/id/b4184 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 948701 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948701 HOGENOM HOG000216615 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000216615&db=HOGENOM6 InParanoid P0AF80 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AF80 InterPro IPR007140 http://www.ebi.ac.uk/interpro/entry/IPR007140 KEGG_Gene ecj:JW4142 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4142 KEGG_Gene eco:b4184 http://www.genome.jp/dbget-bin/www_bget?eco:b4184 KEGG_Orthology KO:K08989 http://www.genome.jp/dbget-bin/www_bget?KO:K08989 OMA ACMTPSV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ACMTPSV PSORT swissprot:YJFL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJFL_ECOLI PSORT-B swissprot:YJFL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJFL_ECOLI PSORT2 swissprot:YJFL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJFL_ECOLI Pfam PF03994 http://pfam.xfam.org/family/PF03994 Phobius swissprot:YJFL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJFL_ECOLI PhylomeDB P0AF80 http://phylomedb.org/?seqid=P0AF80 ProteinModelPortal P0AF80 http://www.proteinmodelportal.org/query/uniprot/P0AF80 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418605 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418605 RefSeq WP_000547760 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000547760 STRING 511145.b4184 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4184&targetmode=cogs STRING COG3766 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3766&targetmode=cogs UniProtKB YJFL_ECOLI http://www.uniprot.org/uniprot/YJFL_ECOLI UniProtKB-AC P0AF80 http://www.uniprot.org/uniprot/P0AF80 charge swissprot:YJFL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJFL_ECOLI eggNOG COG3766 http://eggnogapi.embl.de/nog_data/html/tree/COG3766 eggNOG ENOG4105Z6B http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105Z6B epestfind swissprot:YJFL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJFL_ECOLI garnier swissprot:YJFL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJFL_ECOLI helixturnhelix swissprot:YJFL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJFL_ECOLI hmoment swissprot:YJFL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJFL_ECOLI iep swissprot:YJFL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJFL_ECOLI inforesidue swissprot:YJFL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJFL_ECOLI octanol swissprot:YJFL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJFL_ECOLI pepcoil swissprot:YJFL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJFL_ECOLI pepdigest swissprot:YJFL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJFL_ECOLI pepinfo swissprot:YJFL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJFL_ECOLI pepnet swissprot:YJFL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJFL_ECOLI pepstats swissprot:YJFL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJFL_ECOLI pepwheel swissprot:YJFL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJFL_ECOLI pepwindow swissprot:YJFL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJFL_ECOLI sigcleave swissprot:YJFL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJFL_ECOLI ## Database ID URL or Descriptions # AltName ODP2_ECOLI Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex # AltName ODP2_ECOLI E2 # BioGrid 4261371 5 # CATALYTIC ACTIVITY ODP2_ECOLI Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine. # COFACTOR Name=(R)-lipoate; Xref=ChEBI:CHEBI 83088; Note=Binds 3 lipoyl cofactors covalently.; # EcoGene EG10025 aceF # FUNCTION ODP2_ECOLI The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). # GO_component GO:0005737 cytoplasm; IDA:UniProtKB. # GO_component GO:0045254 pyruvate dehydrogenase complex; IDA:EcoliWiki. # GO_function GO:0004742 dihydrolipoyllysine-residue acetyltransferase activity; IDA:EcoliWiki. # GO_function GO:0031405 lipoic acid binding; IDA:EcoliWiki. # GO_process GO:0006086 acetyl-CoA biosynthetic process from pyruvate; IMP:EcoliWiki. # GO_process GO:0006090 pyruvate metabolic process; IMP:EcoliWiki. # GO_process GO:0006096 glycolytic process; IEA:UniProtKB-KW. # GO_process GO:0055114 oxidation-reduction process; IEA:GOC. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0008289 lipid binding # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.30.559.10 -; 1. # Gene3D 4.10.320.10 -; 1. # INTERACTION ODP2_ECOLI P0AED9 dcm; NbExp=2; IntAct=EBI-542707, EBI-548525; P32053 intA; NbExp=2; IntAct=EBI-542707, EBI-552967; P0A9P0 lpdA; NbExp=3; IntAct=EBI-542707, EBI-542856; P0ADI0 pinR; NbExp=2; IntAct=EBI-542707, EBI-544672; # IntAct P06959 84 # InterPro IPR000089 Biotin_lipoyl # InterPro IPR001078 2-oxoacid_DH_actylTfrase # InterPro IPR003016 2-oxoA_DH_lipoyl-BS # InterPro IPR004167 E3-bd # InterPro IPR006256 AcTrfase_Pyrv_DH_cplx # InterPro IPR011053 Single_hybrid_motif # InterPro IPR023213 CAT-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00010 Glycolysis / Gluconeogenesis # KEGG_Pathway ko00020 Citrate cycle (TCA cycle) # KEGG_Pathway ko00620 Pyruvate metabolism # Organism ODP2_ECOLI Escherichia coli (strain K12) # PATRIC 32115331 VBIEscCol129921_0117 # PDB 1QJO NMR; -; A=206-284 # PDB 2K7V NMR; -; A/B=206-293 # PIR A30278 XXECDP # PROSITE PS00189 LIPOYL; 3 # PROSITE PS50968 BIOTINYL_LIPOYL; 3 # Pfam PF00198 2-oxoacid_dh # Pfam PF00364 Biotin_lipoyl; 3 # Pfam PF02817 E3_binding # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ODP2_ECOLI Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex # RefSeq NP_414657 NC_000913.3 # RefSeq WP_000963518 NZ_LN832404.1 # SIMILARITY Belongs to the 2-oxoacid dehydrogenase family. {ECO 0000305}. # SIMILARITY Contains 3 lipoyl-binding domains. {ECO:0000255|PROSITE-ProRule PRU01066, ECO:0000305}. # SUBUNIT ODP2_ECOLI Forms a 24-polypeptide structural core with octahedral symmetry. # SUPFAM SSF47005 SSF47005 # SUPFAM SSF51230 SSF51230; 3 # TIGRFAMs TIGR01348 PDHac_trf_long # eggNOG COG0508 LUCA # eggNOG ENOG4107QSN Bacteria BLAST swissprot:ODP2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ODP2_ECOLI BioCyc ECOL316407:JW0111-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0111-MONOMER BioCyc EcoCyc:E2P-MONOMER http://biocyc.org/getid?id=EcoCyc:E2P-MONOMER BioCyc MetaCyc:E2P-MONOMER http://biocyc.org/getid?id=MetaCyc:E2P-MONOMER COG COG0508 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0508 DIP DIP-9040N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9040N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj1870905 http://dx.doi.org/10.1042/bj1870905 DOI 10.1042/bj2690443 http://dx.doi.org/10.1042/bj2690443 DOI 10.1042/bj2710139 http://dx.doi.org/10.1042/bj2710139 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1111/j.1432-1033.1983.tb07490.x http://dx.doi.org/10.1111/j.1432-1033.1983.tb07490.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.12 http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.12 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V01498 http://www.ebi.ac.uk/ena/data/view/V01498 ENZYME 2.3.1.12 http://enzyme.expasy.org/EC/2.3.1.12 EchoBASE EB0024 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0024 EcoGene EG10025 http://www.ecogene.org/geneInfo.php?eg_id=EG10025 EnsemblBacteria AAC73226 http://www.ensemblgenomes.org/id/AAC73226 EnsemblBacteria AAC73226 http://www.ensemblgenomes.org/id/AAC73226 EnsemblBacteria BAB96685 http://www.ensemblgenomes.org/id/BAB96685 EnsemblBacteria BAB96685 http://www.ensemblgenomes.org/id/BAB96685 EnsemblBacteria BAB96685 http://www.ensemblgenomes.org/id/BAB96685 EnsemblBacteria b0115 http://www.ensemblgenomes.org/id/b0115 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0045254 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045254 GO_function GO:0004742 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004742 GO_function GO:0031405 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031405 GO_process GO:0006086 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006086 GO_process GO:0006090 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006090 GO_process GO:0006096 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006096 GO_process GO:0055114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0008289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.30.559.10 http://www.cathdb.info/version/latest/superfamily/3.30.559.10 Gene3D 4.10.320.10 http://www.cathdb.info/version/latest/superfamily/4.10.320.10 GeneID 944794 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944794 HOGENOM HOG000281562 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000281562&db=HOGENOM6 InParanoid P06959 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P06959 IntAct P06959 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P06959* IntEnz 2.3.1.12 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.12 InterPro IPR000089 http://www.ebi.ac.uk/interpro/entry/IPR000089 InterPro IPR001078 http://www.ebi.ac.uk/interpro/entry/IPR001078 InterPro IPR003016 http://www.ebi.ac.uk/interpro/entry/IPR003016 InterPro IPR004167 http://www.ebi.ac.uk/interpro/entry/IPR004167 InterPro IPR006256 http://www.ebi.ac.uk/interpro/entry/IPR006256 InterPro IPR011053 http://www.ebi.ac.uk/interpro/entry/IPR011053 InterPro IPR023213 http://www.ebi.ac.uk/interpro/entry/IPR023213 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0111 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0111 KEGG_Gene eco:b0115 http://www.genome.jp/dbget-bin/www_bget?eco:b0115 KEGG_Orthology KO:K00627 http://www.genome.jp/dbget-bin/www_bget?KO:K00627 KEGG_Pathway ko00010 http://www.genome.jp/kegg-bin/show_pathway?ko00010 KEGG_Pathway ko00020 http://www.genome.jp/kegg-bin/show_pathway?ko00020 KEGG_Pathway ko00620 http://www.genome.jp/kegg-bin/show_pathway?ko00620 KEGG_Reaction rn:R02569 http://www.genome.jp/dbget-bin/www_bget?rn:R02569 MINT MINT-1311573 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1311573 OMA GKEFEPR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GKEFEPR PDB 1QJO http://www.ebi.ac.uk/pdbe-srv/view/entry/1QJO PDB 2K7V http://www.ebi.ac.uk/pdbe-srv/view/entry/2K7V PDBsum 1QJO http://www.ebi.ac.uk/pdbsum/1QJO PDBsum 2K7V http://www.ebi.ac.uk/pdbsum/2K7V PROSITE PS00189 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00189 PROSITE PS50968 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50968 PSORT swissprot:ODP2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ODP2_ECOLI PSORT-B swissprot:ODP2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ODP2_ECOLI PSORT2 swissprot:ODP2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ODP2_ECOLI Pfam PF00198 http://pfam.xfam.org/family/PF00198 Pfam PF00364 http://pfam.xfam.org/family/PF00364 Pfam PF02817 http://pfam.xfam.org/family/PF02817 Phobius swissprot:ODP2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ODP2_ECOLI PhylomeDB P06959 http://phylomedb.org/?seqid=P06959 ProteinModelPortal P06959 http://www.proteinmodelportal.org/query/uniprot/P06959 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 2121129 http://www.ncbi.nlm.nih.gov/pubmed/2121129 PubMed 2201286 http://www.ncbi.nlm.nih.gov/pubmed/2201286 PubMed 6345153 http://www.ncbi.nlm.nih.gov/pubmed/6345153 PubMed 6821375 http://www.ncbi.nlm.nih.gov/pubmed/6821375 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_414657 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414657 RefSeq WP_000963518 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000963518 SMR P06959 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P06959 STRING 511145.b0115 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0115&targetmode=cogs STRING COG0508 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0508&targetmode=cogs SUPFAM SSF47005 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47005 SUPFAM SSF51230 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51230 SWISS-2DPAGE P06959 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P06959 TIGRFAMs TIGR01348 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01348 UniProtKB ODP2_ECOLI http://www.uniprot.org/uniprot/ODP2_ECOLI UniProtKB-AC P06959 http://www.uniprot.org/uniprot/P06959 charge swissprot:ODP2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ODP2_ECOLI eggNOG COG0508 http://eggnogapi.embl.de/nog_data/html/tree/COG0508 eggNOG ENOG4107QSN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QSN epestfind swissprot:ODP2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ODP2_ECOLI garnier swissprot:ODP2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ODP2_ECOLI helixturnhelix swissprot:ODP2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ODP2_ECOLI hmoment swissprot:ODP2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ODP2_ECOLI iep swissprot:ODP2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ODP2_ECOLI inforesidue swissprot:ODP2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ODP2_ECOLI octanol swissprot:ODP2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ODP2_ECOLI pepcoil swissprot:ODP2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ODP2_ECOLI pepdigest swissprot:ODP2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ODP2_ECOLI pepinfo swissprot:ODP2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ODP2_ECOLI pepnet swissprot:ODP2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ODP2_ECOLI pepstats swissprot:ODP2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ODP2_ECOLI pepwheel swissprot:ODP2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ODP2_ECOLI pepwindow swissprot:ODP2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ODP2_ECOLI sigcleave swissprot:ODP2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ODP2_ECOLI ## Database ID URL or Descriptions # BioGrid 4260319 21 # EcoGene EG14001 ydjY # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # InterPro IPR017896 4Fe4S_Fe-S-bd # Organism YDJY_ECOLI Escherichia coli (strain K12) # PATRIC 32118813 VBIEscCol129921_1824 # PIR G64934 G64934 # PROSITE PS51379 4FE4S_FER_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDJY_ECOLI Uncharacterized protein YdjY # RefSeq NP_416265 NC_000913.3 # RefSeq WP_000939212 NZ_LN832404.1 # SIMILARITY Contains 1 4Fe-4S ferredoxin-type domain. {ECO:0000255|PROSITE-ProRule PRU00711}. # eggNOG ENOG4108KCW Bacteria # eggNOG ENOG41100DI LUCA BLAST swissprot:YDJY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDJY_ECOLI BioCyc ECOL316407:JW5283-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5283-MONOMER BioCyc EcoCyc:G6946-MONOMER http://biocyc.org/getid?id=EcoCyc:G6946-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3757 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3757 EcoGene EG14001 http://www.ecogene.org/geneInfo.php?eg_id=EG14001 EnsemblBacteria AAC74821 http://www.ensemblgenomes.org/id/AAC74821 EnsemblBacteria AAC74821 http://www.ensemblgenomes.org/id/AAC74821 EnsemblBacteria BAE76518 http://www.ensemblgenomes.org/id/BAE76518 EnsemblBacteria BAE76518 http://www.ensemblgenomes.org/id/BAE76518 EnsemblBacteria BAE76518 http://www.ensemblgenomes.org/id/BAE76518 EnsemblBacteria b1751 http://www.ensemblgenomes.org/id/b1751 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GeneID 946248 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946248 HOGENOM HOG000121098 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000121098&db=HOGENOM6 InterPro IPR017896 http://www.ebi.ac.uk/interpro/entry/IPR017896 KEGG_Gene ecj:JW5283 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5283 KEGG_Gene eco:b1751 http://www.genome.jp/dbget-bin/www_bget?eco:b1751 OMA RTMSQHY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RTMSQHY PROSITE PS51379 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51379 PSORT swissprot:YDJY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDJY_ECOLI PSORT-B swissprot:YDJY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDJY_ECOLI PSORT2 swissprot:YDJY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDJY_ECOLI Phobius swissprot:YDJY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDJY_ECOLI ProteinModelPortal P76220 http://www.proteinmodelportal.org/query/uniprot/P76220 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416265 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416265 RefSeq WP_000939212 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000939212 SMR P76220 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76220 STRING 511145.b1751 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1751&targetmode=cogs UniProtKB YDJY_ECOLI http://www.uniprot.org/uniprot/YDJY_ECOLI UniProtKB-AC P76220 http://www.uniprot.org/uniprot/P76220 charge swissprot:YDJY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDJY_ECOLI eggNOG ENOG4108KCW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108KCW eggNOG ENOG41100DI http://eggnogapi.embl.de/nog_data/html/tree/ENOG41100DI epestfind swissprot:YDJY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDJY_ECOLI garnier swissprot:YDJY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDJY_ECOLI helixturnhelix swissprot:YDJY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDJY_ECOLI hmoment swissprot:YDJY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDJY_ECOLI iep swissprot:YDJY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDJY_ECOLI inforesidue swissprot:YDJY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDJY_ECOLI octanol swissprot:YDJY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDJY_ECOLI pepcoil swissprot:YDJY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDJY_ECOLI pepdigest swissprot:YDJY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDJY_ECOLI pepinfo swissprot:YDJY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDJY_ECOLI pepnet swissprot:YDJY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDJY_ECOLI pepstats swissprot:YDJY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDJY_ECOLI pepwheel swissprot:YDJY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDJY_ECOLI pepwindow swissprot:YDJY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDJY_ECOLI sigcleave swissprot:YDJY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDJY_ECOLI ## Database ID URL or Descriptions # BioGrid 4261948 13 # DISRUPTION PHENOTYPE RCBA_ECOLI Mutants show increased numbers of double- strand breaks (PubMed 22343303). The single ralR and double ralR- ralA mutant have increased sensitivity to the antibiotic fosfomycin. {ECO 0000269|PubMed 22343303, ECO 0000269|PubMed 24748661}. # EcoGene EG11901 ydaC # FUNCTION RCBA_ECOLI Helps to maintain the integrity of the chromosome by lowering the steady-state level of double strand breaks (PubMed 22343303). This region of DNA acts as an antitoxin to toxin RalR, a DNase, but it seems to be sRNA RalA that has the antitoxin activity and not this putative protein. Therefore the identity of this as a protein-coding gene has been cast into doubt (PubMed 24748661). {ECO 0000269|PubMed 22343303, ECO 0000269|PubMed 24748661}. # GO_process GO:0006259 DNA metabolic process; IMP:EcoCyc. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0008150 biological_process # IntAct P33230 4 # InterPro IPR009572 DUF1187 # Organism RCBA_ECOLI Escherichia coli (strain K12) # PIR F64884 F64884 # Pfam PF06688 DUF1187 # ProDom PD055514 DUF1187 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Double-strand break reduction protein {ECO:0000303|PubMed 22343303} # RefSeq NP_415863 NC_000913.3 # RefSeq WP_000276809 NZ_CP014272.1 # eggNOG ENOG41070YT Bacteria # eggNOG ENOG410YWP5 LUCA BLAST swissprot:RCBA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RCBA_ECOLI BioCyc ECOL316407:JW1341-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1341-MONOMER BioCyc EcoCyc:EG11901-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11901-MONOMER DIP DIP-11619N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11619N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/gku279 http://dx.doi.org/10.1093/nar/gku279 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.06390-11 http://dx.doi.org/10.1128/JB.06390-11 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L23927 http://www.ebi.ac.uk/ena/data/view/L23927 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1846 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1846 EcoGene EG11901 http://www.ecogene.org/geneInfo.php?eg_id=EG11901 EnsemblBacteria AAC74429 http://www.ensemblgenomes.org/id/AAC74429 EnsemblBacteria AAC74429 http://www.ensemblgenomes.org/id/AAC74429 EnsemblBacteria BAA14947 http://www.ensemblgenomes.org/id/BAA14947 EnsemblBacteria BAA14947 http://www.ensemblgenomes.org/id/BAA14947 EnsemblBacteria BAA14947 http://www.ensemblgenomes.org/id/BAA14947 EnsemblBacteria b1347 http://www.ensemblgenomes.org/id/b1347 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 947504 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947504 HOGENOM HOG000120153 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120153&db=HOGENOM6 IntAct P33230 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33230* InterPro IPR009572 http://www.ebi.ac.uk/interpro/entry/IPR009572 KEGG_Gene ecj:JW1341 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1341 KEGG_Gene eco:b1347 http://www.genome.jp/dbget-bin/www_bget?eco:b1347 OMA TRYSKTK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TRYSKTK PSORT swissprot:RCBA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RCBA_ECOLI PSORT-B swissprot:RCBA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RCBA_ECOLI PSORT2 swissprot:RCBA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RCBA_ECOLI Pfam PF06688 http://pfam.xfam.org/family/PF06688 Phobius swissprot:RCBA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RCBA_ECOLI ProteinModelPortal P33230 http://www.proteinmodelportal.org/query/uniprot/P33230 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22343303 http://www.ncbi.nlm.nih.gov/pubmed/22343303 PubMed 24748661 http://www.ncbi.nlm.nih.gov/pubmed/24748661 PubMed 8244937 http://www.ncbi.nlm.nih.gov/pubmed/8244937 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415863 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415863 RefSeq WP_000276809 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000276809 STRING 511145.b1347 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1347&targetmode=cogs UniProtKB RCBA_ECOLI http://www.uniprot.org/uniprot/RCBA_ECOLI UniProtKB-AC P33230 http://www.uniprot.org/uniprot/P33230 charge swissprot:RCBA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RCBA_ECOLI eggNOG ENOG41070YT http://eggnogapi.embl.de/nog_data/html/tree/ENOG41070YT eggNOG ENOG410YWP5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YWP5 epestfind swissprot:RCBA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RCBA_ECOLI garnier swissprot:RCBA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RCBA_ECOLI helixturnhelix swissprot:RCBA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RCBA_ECOLI hmoment swissprot:RCBA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RCBA_ECOLI iep swissprot:RCBA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RCBA_ECOLI inforesidue swissprot:RCBA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RCBA_ECOLI octanol swissprot:RCBA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RCBA_ECOLI pepcoil swissprot:RCBA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RCBA_ECOLI pepdigest swissprot:RCBA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RCBA_ECOLI pepinfo swissprot:RCBA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RCBA_ECOLI pepnet swissprot:RCBA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RCBA_ECOLI pepstats swissprot:RCBA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RCBA_ECOLI pepwheel swissprot:RCBA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RCBA_ECOLI pepwindow swissprot:RCBA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RCBA_ECOLI sigcleave swissprot:RCBA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RCBA_ECOLI ## Database ID URL or Descriptions # AltName COABC_ECOLI CoaB # AltName COABC_ECOLI CoaC # AltName COABC_ECOLI CoaC # AltName COABC_ECOLI DNA/pantothenate metabolism flavoprotein # AltName COABC_ECOLI DNA/pantothenate metabolism flavoprotein # AltName COABC_ECOLI PPC synthetase # AltName COABC_ECOLI Phosphopantothenoylcysteine synthase # BRENDA 6.3.2 2026 # CATALYTIC ACTIVITY COABC_ECOLI CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + N-((R)-4'-phosphopantothenoyl)-L-cysteine. # CATALYTIC ACTIVITY COABC_ECOLI N-((R)-4'-phosphopantothenoyl)-L-cysteine = pantotheine 4'-phosphate + CO(2). # COFACTOR Name=FMN; Xref=ChEBI:CHEBI 58210; Note=Binds 1 FMN per subunit.; # COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI 18420; # EcoGene EG10004 dfp # FUNCTION COABC_ECOLI Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004632 phosphopantothenate--cysteine ligase activity; IDA:EcoCyc. # GO_function GO:0004633 phosphopantothenoylcysteine decarboxylase activity; IDA:EcoCyc. # GO_function GO:0010181 FMN binding; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0015937 coenzyme A biosynthetic process; IDA:EcoCyc. # GO_process GO:0015941 pantothenate catabolic process; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.10300 -; 1. # Gene3D 3.40.50.1950 -; 1. # IntAct P0ABQ0 2 # InterPro IPR003382 Flavoprotein # InterPro IPR005252 CoaBC # InterPro IPR007085 DNA/pantothenate-metab_flavo_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00770 Pantothenate and CoA biosynthesis # Organism COABC_ECOLI Escherichia coli (strain K12) # PATHWAY Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate step 2/5. # PATHWAY Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate step 3/5. # PATRIC 32122765 VBIEscCol129921_3759 # PDB 1U7U X-ray; 2.40 A; A=181-406 # PDB 1U7W X-ray; 2.50 A; A/B/C=181-406 # PDB 1U7Z X-ray; 2.30 A; A/B/C=181-406 # PDB 1U80 X-ray; 2.85 A; A/B/C=181-406 # Pfam PF02441 Flavoprotein # Pfam PF04127 DFP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName COABC_ECOLI Coenzyme A biosynthesis bifunctional protein CoaBC # RecName COABC_ECOLI Phosphopantothenate--cysteine ligase # RecName COABC_ECOLI Phosphopantothenoylcysteine decarboxylase # RefSeq NP_418096 NC_000913.3 # RefSeq WP_000050139 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA61992.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY In the C-terminal section; belongs to the PPC synthetase family. {ECO 0000305}. # SIMILARITY In the N-terminal section; belongs to the HFCD (homo- oligomeric flavin containing Cys decarboxylase) superfamily. {ECO 0000305}. # SUBUNIT COABC_ECOLI Homododecamer, the CoaB domains form homodimers. # SUPFAM SSF102645 SSF102645 # SUPFAM SSF52507 SSF52507 # TIGRFAMs TIGR00521 coaBC_dfp # UniPathway UPA00241 UER00353 # UniPathway UPA00241 UER00354 # eggNOG COG0452 LUCA # eggNOG ENOG4105CJS Bacteria BLAST swissprot:COABC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:COABC_ECOLI BioCyc ECOL316407:JW5642-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5642-MONOMER BioCyc EcoCyc:EG10004-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10004-MONOMER BioCyc MetaCyc:EG10004-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10004-MONOMER COG COG0452 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0452 DIP DIP-48472N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48472N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1016/j.str.2004.08.007 http://dx.doi.org/10.1016/j.str.2004.08.007 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1432-1033.2003.03916.x http://dx.doi.org/10.1046/j.1432-1033.2003.03916.x DOI 10.1074/jbc.C100033200 http://dx.doi.org/10.1074/jbc.C100033200 DOI 10.1074/jbc.M004273200 http://dx.doi.org/10.1074/jbc.M004273200 DOI 10.1074/jbc.M103342200 http://dx.doi.org/10.1074/jbc.M103342200 DOI 10.1074/jbc.M206188200 http://dx.doi.org/10.1074/jbc.M206188200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.1.1.36 http://www.genome.jp/dbget-bin/www_bget?EC:4.1.1.36 EC_number EC:6.3.2.5 http://www.genome.jp/dbget-bin/www_bget?EC:6.3.2.5 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V01578 http://www.ebi.ac.uk/ena/data/view/V01578 ENZYME 4.1.1.36 http://enzyme.expasy.org/EC/4.1.1.36 ENZYME 6.3.2.5 http://enzyme.expasy.org/EC/6.3.2.5 EchoBASE EB0004 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0004 EcoGene EG10004 http://www.ecogene.org/geneInfo.php?eg_id=EG10004 EnsemblBacteria AAC76663 http://www.ensemblgenomes.org/id/AAC76663 EnsemblBacteria AAC76663 http://www.ensemblgenomes.org/id/AAC76663 EnsemblBacteria BAE77653 http://www.ensemblgenomes.org/id/BAE77653 EnsemblBacteria BAE77653 http://www.ensemblgenomes.org/id/BAE77653 EnsemblBacteria BAE77653 http://www.ensemblgenomes.org/id/BAE77653 EnsemblBacteria b3639 http://www.ensemblgenomes.org/id/b3639 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004632 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004632 GO_function GO:0004633 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004633 GO_function GO:0010181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010181 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0015937 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015937 GO_process GO:0015941 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015941 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.10300 http://www.cathdb.info/version/latest/superfamily/3.40.50.10300 Gene3D 3.40.50.1950 http://www.cathdb.info/version/latest/superfamily/3.40.50.1950 GeneID 949047 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949047 HOGENOM HOG000037526 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000037526&db=HOGENOM6 InParanoid P0ABQ0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABQ0 IntAct P0ABQ0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABQ0* IntEnz 4.1.1.36 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.1.36 IntEnz 6.3.2.5 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.2.5 InterPro IPR003382 http://www.ebi.ac.uk/interpro/entry/IPR003382 InterPro IPR005252 http://www.ebi.ac.uk/interpro/entry/IPR005252 InterPro IPR007085 http://www.ebi.ac.uk/interpro/entry/IPR007085 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5642 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5642 KEGG_Gene eco:b3639 http://www.genome.jp/dbget-bin/www_bget?eco:b3639 KEGG_Orthology KO:K13038 http://www.genome.jp/dbget-bin/www_bget?KO:K13038 KEGG_Pathway ko00770 http://www.genome.jp/kegg-bin/show_pathway?ko00770 KEGG_Reaction rn:R03269 http://www.genome.jp/dbget-bin/www_bget?rn:R03269 KEGG_Reaction rn:R04230 http://www.genome.jp/dbget-bin/www_bget?rn:R04230 KEGG_Reaction rn:R04231 http://www.genome.jp/dbget-bin/www_bget?rn:R04231 OMA VVFAPAM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VVFAPAM PDB 1U7U http://www.ebi.ac.uk/pdbe-srv/view/entry/1U7U PDB 1U7W http://www.ebi.ac.uk/pdbe-srv/view/entry/1U7W PDB 1U7Z http://www.ebi.ac.uk/pdbe-srv/view/entry/1U7Z PDB 1U80 http://www.ebi.ac.uk/pdbe-srv/view/entry/1U80 PDBsum 1U7U http://www.ebi.ac.uk/pdbsum/1U7U PDBsum 1U7W http://www.ebi.ac.uk/pdbsum/1U7W PDBsum 1U7Z http://www.ebi.ac.uk/pdbsum/1U7Z PDBsum 1U80 http://www.ebi.ac.uk/pdbsum/1U80 PSORT swissprot:COABC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:COABC_ECOLI PSORT-B swissprot:COABC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:COABC_ECOLI PSORT2 swissprot:COABC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:COABC_ECOLI Pfam PF02441 http://pfam.xfam.org/family/PF02441 Pfam PF04127 http://pfam.xfam.org/family/PF04127 Phobius swissprot:COABC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:COABC_ECOLI PhylomeDB P0ABQ0 http://phylomedb.org/?seqid=P0ABQ0 ProteinModelPortal P0ABQ0 http://www.proteinmodelportal.org/query/uniprot/P0ABQ0 PubMed 10922366 http://www.ncbi.nlm.nih.gov/pubmed/10922366 PubMed 11278255 http://www.ncbi.nlm.nih.gov/pubmed/11278255 PubMed 11358972 http://www.ncbi.nlm.nih.gov/pubmed/11358972 PubMed 12140293 http://www.ncbi.nlm.nih.gov/pubmed/12140293 PubMed 14686929 http://www.ncbi.nlm.nih.gov/pubmed/14686929 PubMed 15530362 http://www.ncbi.nlm.nih.gov/pubmed/15530362 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6139280 http://www.ncbi.nlm.nih.gov/pubmed/6139280 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418096 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418096 RefSeq WP_000050139 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000050139 SMR P0ABQ0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABQ0 STRING 511145.b3639 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3639&targetmode=cogs STRING COG0452 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0452&targetmode=cogs SUPFAM SSF102645 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF102645 SUPFAM SSF52507 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52507 TIGRFAMs TIGR00521 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00521 UniProtKB COABC_ECOLI http://www.uniprot.org/uniprot/COABC_ECOLI UniProtKB-AC P0ABQ0 http://www.uniprot.org/uniprot/P0ABQ0 charge swissprot:COABC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:COABC_ECOLI eggNOG COG0452 http://eggnogapi.embl.de/nog_data/html/tree/COG0452 eggNOG ENOG4105CJS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CJS epestfind swissprot:COABC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:COABC_ECOLI garnier swissprot:COABC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:COABC_ECOLI helixturnhelix swissprot:COABC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:COABC_ECOLI hmoment swissprot:COABC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:COABC_ECOLI iep swissprot:COABC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:COABC_ECOLI inforesidue swissprot:COABC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:COABC_ECOLI octanol swissprot:COABC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:COABC_ECOLI pepcoil swissprot:COABC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:COABC_ECOLI pepdigest swissprot:COABC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:COABC_ECOLI pepinfo swissprot:COABC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:COABC_ECOLI pepnet swissprot:COABC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:COABC_ECOLI pepstats swissprot:COABC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:COABC_ECOLI pepwheel swissprot:COABC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:COABC_ECOLI pepwindow swissprot:COABC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:COABC_ECOLI sigcleave swissprot:COABC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:COABC_ECOLI ## Database ID URL or Descriptions # AltName MCP3_ECOLI Ribose and galactose chemoreceptor protein # BioGrid 4261384 311 # CDD cd00181 Tar_Tsr_LBD # CDD cd06225 HAMP # EcoGene EG11018 trg # FUNCTION MCP3_ECOLI Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. Attractants increase the level of methylation while repellents decrease the level of methylation, the methyl groups are added by the methyltransferase CheR and removed by the methylesterase CheB. # FUNCTION MCP3_ECOLI Mediates taxis to the sugars ribose and galactose via an interaction with the periplasmic ribose- or galactose-binding proteins. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0004888 transmembrane signaling receptor activity; IMP:EcoCyc. # GO_process GO:0006935 chemotaxis; IMP:EcoCyc. # GO_process GO:0007165 signal transduction; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0004871 signal transducer activity # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0040011 locomotion # Gene3D 1.20.120.30 -; 1. # INTERACTION MCP3_ECOLI P45543 frlD; NbExp=5; IntAct=EBI-557436, EBI-562037; # IntAct P05704 5 # InterPro IPR003122 Chemotax_Me-accpt_rcpt_lig-bd # InterPro IPR003660 HAMP_dom # InterPro IPR004089 MCPsignal_dom # InterPro IPR004090 Chemotax_Me-accpt_rcpt # InterPro IPR004091 Chemotax_Me-accpt_rcpt_Me-site # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Pathway ko02020 Two-component system # KEGG_Pathway ko02030 Bacterial chemotaxis # Organism MCP3_ECOLI Escherichia coli (strain K12) # PATRIC 32118128 VBIEscCol129921_1484 # PIR H64893 QREC3M # PRINTS PR00260 CHEMTRNSDUCR # PROSITE PS00538 CHEMOTAXIS_TRANSDUC_1 # PROSITE PS50111 CHEMOTAXIS_TRANSDUC_2 # PROSITE PS50885 HAMP # Pfam PF00015 MCPsignal # Pfam PF00672 HAMP # Pfam PF02203 TarH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MCP3_ECOLI Methyl-accepting chemotaxis protein III # RefSeq NP_415938 NC_000913.3 # RefSeq WP_001098559 NZ_LN832404.1 # SIMILARITY Contains 1 HAMP domain. {ECO:0000255|PROSITE- ProRule PRU00102}. # SIMILARITY Contains 1 methyl-accepting transducer domain. {ECO:0000255|PROSITE-ProRule PRU00284}. # SMART SM00283 MA # SMART SM00304 HAMP # SMART SM00319 TarH # SUBCELLULAR LOCATION MCP3_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 22380631}; Multi- pass membrane protein {ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 22380631}. Note=Found predominantly at cell poles. # SUPFAM SSF47170 SSF47170 # eggNOG COG0840 LUCA # eggNOG ENOG4105C8Q Bacteria BLAST swissprot:MCP3_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MCP3_ECOLI BioCyc ECOL316407:JW1417-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1417-MONOMER BioCyc EcoCyc:TRG-MONOMER http://biocyc.org/getid?id=EcoCyc:TRG-MONOMER COG COG0840 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0840 DIP DIP-11027N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11027N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.81.11.3287 http://dx.doi.org/10.1073/pnas.81.11.3287 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1111/j.1365-2958.2012.08021.x http://dx.doi.org/10.1111/j.1365-2958.2012.08021.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K02073 http://www.ebi.ac.uk/ena/data/view/K02073 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1011 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1011 EcoGene EG11018 http://www.ecogene.org/geneInfo.php?eg_id=EG11018 EnsemblBacteria AAC74503 http://www.ensemblgenomes.org/id/AAC74503 EnsemblBacteria AAC74503 http://www.ensemblgenomes.org/id/AAC74503 EnsemblBacteria BAA15044 http://www.ensemblgenomes.org/id/BAA15044 EnsemblBacteria BAA15044 http://www.ensemblgenomes.org/id/BAA15044 EnsemblBacteria BAA15044 http://www.ensemblgenomes.org/id/BAA15044 EnsemblBacteria b1421 http://www.ensemblgenomes.org/id/b1421 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0004888 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004888 GO_process GO:0006935 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006935 GO_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0040011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011 Gene3D 1.20.120.30 http://www.cathdb.info/version/latest/superfamily/1.20.120.30 GeneID 945995 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945995 HOGENOM HOG000148074 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000148074&db=HOGENOM6 InParanoid P05704 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P05704 IntAct P05704 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P05704* InterPro IPR003122 http://www.ebi.ac.uk/interpro/entry/IPR003122 InterPro IPR003660 http://www.ebi.ac.uk/interpro/entry/IPR003660 InterPro IPR004089 http://www.ebi.ac.uk/interpro/entry/IPR004089 InterPro IPR004090 http://www.ebi.ac.uk/interpro/entry/IPR004090 InterPro IPR004091 http://www.ebi.ac.uk/interpro/entry/IPR004091 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW1417 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1417 KEGG_Gene eco:b1421 http://www.genome.jp/dbget-bin/www_bget?eco:b1421 KEGG_Orthology KO:K05876 http://www.genome.jp/dbget-bin/www_bget?KO:K05876 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 KEGG_Pathway ko02030 http://www.genome.jp/kegg-bin/show_pathway?ko02030 MINT MINT-1228342 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1228342 OMA NRHLQQM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NRHLQQM PRINTS PR00260 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00260 PROSITE PS00538 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00538 PROSITE PS50111 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50111 PROSITE PS50885 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50885 PSORT swissprot:MCP3_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MCP3_ECOLI PSORT-B swissprot:MCP3_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MCP3_ECOLI PSORT2 swissprot:MCP3_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MCP3_ECOLI Pfam PF00015 http://pfam.xfam.org/family/PF00015 Pfam PF00672 http://pfam.xfam.org/family/PF00672 Pfam PF02203 http://pfam.xfam.org/family/PF02203 Phobius swissprot:MCP3_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MCP3_ECOLI PhylomeDB P05704 http://phylomedb.org/?seqid=P05704 ProteinModelPortal P05704 http://www.proteinmodelportal.org/query/uniprot/P05704 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22380631 http://www.ncbi.nlm.nih.gov/pubmed/22380631 PubMed 6300110 http://www.ncbi.nlm.nih.gov/pubmed/6300110 PubMed 6374654 http://www.ncbi.nlm.nih.gov/pubmed/6374654 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415938 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415938 RefSeq WP_001098559 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001098559 SMART SM00283 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00283 SMART SM00304 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00304 SMART SM00319 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00319 SMR P05704 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P05704 STRING 511145.b1421 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1421&targetmode=cogs STRING COG0840 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0840&targetmode=cogs SUPFAM SSF47170 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47170 UniProtKB MCP3_ECOLI http://www.uniprot.org/uniprot/MCP3_ECOLI UniProtKB-AC P05704 http://www.uniprot.org/uniprot/P05704 charge swissprot:MCP3_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MCP3_ECOLI eggNOG COG0840 http://eggnogapi.embl.de/nog_data/html/tree/COG0840 eggNOG ENOG4105C8Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C8Q epestfind swissprot:MCP3_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MCP3_ECOLI garnier swissprot:MCP3_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MCP3_ECOLI helixturnhelix swissprot:MCP3_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MCP3_ECOLI hmoment swissprot:MCP3_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MCP3_ECOLI iep swissprot:MCP3_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MCP3_ECOLI inforesidue swissprot:MCP3_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MCP3_ECOLI octanol swissprot:MCP3_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MCP3_ECOLI pepcoil swissprot:MCP3_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MCP3_ECOLI pepdigest swissprot:MCP3_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MCP3_ECOLI pepinfo swissprot:MCP3_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MCP3_ECOLI pepnet swissprot:MCP3_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MCP3_ECOLI pepstats swissprot:MCP3_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MCP3_ECOLI pepwheel swissprot:MCP3_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MCP3_ECOLI pepwindow swissprot:MCP3_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MCP3_ECOLI sigcleave swissprot:MCP3_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MCP3_ECOLI ## Database ID URL or Descriptions # AltName RLUA_ECOLI 23S rRNA pseudouridine(746) synthase # AltName RLUA_ECOLI rRNA pseudouridylate synthase A # AltName RLUA_ECOLI rRNA-uridine isomerase A # AltName RLUA_ECOLI tRNA pseudouridine(32) synthase # BRENDA 5.4.99.28 2026 # BRENDA 5.4.99.29 2026 # BioGrid 4262040 11 # CATALYTIC ACTIVITY 23S rRNA uridine(746) = 23S rRNA pseudouridine(746). {ECO:0000269|PubMed 7493321}. # CATALYTIC ACTIVITY tRNA uridine(32) = tRNA pseudouridine(32). {ECO:0000269|PubMed 7493321}. # EcoGene EG12609 rluA # FUNCTION RLUA_ECOLI Responsible for synthesis of pseudouridine from uracil- 746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs. {ECO 0000269|PubMed 10383384, ECO 0000269|PubMed 7493321}. # GO_function GO:0003723 RNA binding; IEA:InterPro. # GO_function GO:0009982 pseudouridine synthase activity; IDA:EcoCyc. # GO_process GO:0000455 enzyme-directed rRNA pseudouridine synthesis; IMP:EcoCyc. # GO_process GO:0001522 pseudouridine synthesis; IMP:EcoliWiki. # GO_process GO:0006364 rRNA processing; IMP:EcoliWiki. # GO_process GO:0008033 tRNA processing; IMP:EcoliWiki. # GO_process GO:0009451 RNA modification; IMP:EcoliWiki. # GO_process GO:0031118 rRNA pseudouridine synthesis; IMP:EcoliWiki. # GO_process GO:0031119 tRNA pseudouridine synthesis; IMP:EcoCyc. # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # IntAct P0AA37 4 # InterPro IPR006145 PsdUridine_synth_RsuA/RluD # InterPro IPR006224 PsdUridine_synth_RluC/D_CS # InterPro IPR006225 PsdUridine_synth_RluC/D # InterPro IPR020103 PsdUridine_synth_cat_dom # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # KEGG_Brite ko03016 Transfer RNA biogenesis # Organism RLUA_ECOLI Escherichia coli (strain K12) # PATRIC 32115215 VBIEscCol129921_0059 # PDB 2I82 X-ray; 2.05 A; A/B/C/D=3-219 # PIR B64727 B64727 # PROSITE PS01129 PSI_RLU # Pfam PF00849 PseudoU_synth_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RLUA_ECOLI Ribosomal large subunit pseudouridine synthase A # RefSeq NP_414600 NC_000913.3 # RefSeq WP_000525176 NZ_LN832404.1 # SIMILARITY Belongs to the pseudouridine synthase RluA family. {ECO 0000305}. # SUPFAM SSF55120 SSF55120 # TIGRFAMs TIGR00005 rluA_subfam # eggNOG COG0564 LUCA # eggNOG ENOG4105D3G Bacteria BLAST swissprot:RLUA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RLUA_ECOLI BioCyc ECOL316407:JW0057-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0057-MONOMER BioCyc EcoCyc:EG12609-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12609-MONOMER BioCyc MetaCyc:EG12609-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12609-MONOMER COG COG0564 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0564 DIP DIP-47988N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47988N DOI 10.1016/0378-1119(94)90688-2 http://dx.doi.org/10.1016/0378-1119(94)90688-2 DOI 10.1021/bi001079n http://dx.doi.org/10.1021/bi001079n DOI 10.1021/bi9913911 http://dx.doi.org/10.1021/bi9913911 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.274.27.18880 http://dx.doi.org/10.1074/jbc.274.27.18880 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.4.99.28 http://www.genome.jp/dbget-bin/www_bget?EC:5.4.99.28 EC_number EC:5.4.99.29 http://www.genome.jp/dbget-bin/www_bget?EC:5.4.99.29 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 5.4.99.28 http://enzyme.expasy.org/EC/5.4.99.28 ENZYME 5.4.99.29 http://enzyme.expasy.org/EC/5.4.99.29 EchoBASE EB2493 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2493 EcoGene EG12609 http://www.ecogene.org/geneInfo.php?eg_id=EG12609 EnsemblBacteria AAC73169 http://www.ensemblgenomes.org/id/AAC73169 EnsemblBacteria AAC73169 http://www.ensemblgenomes.org/id/AAC73169 EnsemblBacteria BAE76039 http://www.ensemblgenomes.org/id/BAE76039 EnsemblBacteria BAE76039 http://www.ensemblgenomes.org/id/BAE76039 EnsemblBacteria BAE76039 http://www.ensemblgenomes.org/id/BAE76039 EnsemblBacteria b0058 http://www.ensemblgenomes.org/id/b0058 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0009982 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009982 GO_process GO:0000455 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000455 GO_process GO:0001522 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001522 GO_process GO:0006364 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006364 GO_process GO:0008033 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008033 GO_process GO:0009451 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009451 GO_process GO:0031118 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031118 GO_process GO:0031119 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031119 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 946262 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946262 HOGENOM HOG000275919 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275919&db=HOGENOM6 InParanoid P0AA37 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AA37 IntAct P0AA37 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AA37* IntEnz 5.4.99.28 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.4.99.28 IntEnz 5.4.99.29 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.4.99.29 InterPro IPR006145 http://www.ebi.ac.uk/interpro/entry/IPR006145 InterPro IPR006224 http://www.ebi.ac.uk/interpro/entry/IPR006224 InterPro IPR006225 http://www.ebi.ac.uk/interpro/entry/IPR006225 InterPro IPR020103 http://www.ebi.ac.uk/interpro/entry/IPR020103 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW0057 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0057 KEGG_Gene eco:b0058 http://www.genome.jp/dbget-bin/www_bget?eco:b0058 KEGG_Orthology KO:K06177 http://www.genome.jp/dbget-bin/www_bget?KO:K06177 OMA EKYGFCE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EKYGFCE PDB 2I82 http://www.ebi.ac.uk/pdbe-srv/view/entry/2I82 PDBsum 2I82 http://www.ebi.ac.uk/pdbsum/2I82 PROSITE PS01129 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01129 PSORT swissprot:RLUA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RLUA_ECOLI PSORT-B swissprot:RLUA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RLUA_ECOLI PSORT2 swissprot:RLUA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RLUA_ECOLI Pfam PF00849 http://pfam.xfam.org/family/PF00849 Phobius swissprot:RLUA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RLUA_ECOLI PhylomeDB P0AA37 http://phylomedb.org/?seqid=P0AA37 ProteinModelPortal P0AA37 http://www.proteinmodelportal.org/query/uniprot/P0AA37 PubMed 10383384 http://www.ncbi.nlm.nih.gov/pubmed/10383384 PubMed 10529181 http://www.ncbi.nlm.nih.gov/pubmed/10529181 PubMed 10924141 http://www.ncbi.nlm.nih.gov/pubmed/10924141 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7493321 http://www.ncbi.nlm.nih.gov/pubmed/7493321 PubMed 7958944 http://www.ncbi.nlm.nih.gov/pubmed/7958944 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414600 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414600 RefSeq WP_000525176 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000525176 SMR P0AA37 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AA37 STRING 511145.b0058 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0058&targetmode=cogs STRING COG0564 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0564&targetmode=cogs SUPFAM SSF55120 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55120 TIGRFAMs TIGR00005 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00005 UniProtKB RLUA_ECOLI http://www.uniprot.org/uniprot/RLUA_ECOLI UniProtKB-AC P0AA37 http://www.uniprot.org/uniprot/P0AA37 charge swissprot:RLUA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RLUA_ECOLI eggNOG COG0564 http://eggnogapi.embl.de/nog_data/html/tree/COG0564 eggNOG ENOG4105D3G http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D3G epestfind swissprot:RLUA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RLUA_ECOLI garnier swissprot:RLUA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RLUA_ECOLI helixturnhelix swissprot:RLUA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RLUA_ECOLI hmoment swissprot:RLUA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RLUA_ECOLI iep swissprot:RLUA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RLUA_ECOLI inforesidue swissprot:RLUA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RLUA_ECOLI octanol swissprot:RLUA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RLUA_ECOLI pepcoil swissprot:RLUA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RLUA_ECOLI pepdigest swissprot:RLUA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RLUA_ECOLI pepinfo swissprot:RLUA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RLUA_ECOLI pepnet swissprot:RLUA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RLUA_ECOLI pepstats swissprot:RLUA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RLUA_ECOLI pepwheel swissprot:RLUA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RLUA_ECOLI pepwindow swissprot:RLUA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RLUA_ECOLI sigcleave swissprot:RLUA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RLUA_ECOLI ## Database ID URL or Descriptions # AltName HINT_ECOLI Histidine triad nucleotide binding protein HinT # BioGrid 4261963 7 # DISRUPTION PHENOTYPE HINT_ECOLI Cells lacking this gene fail to grow on both D and L isomers of alanine due to a defect in DadA dehydrogenase activity, preventing D-alanine utilization (PubMed 21754980). The mutant cells do not have appreciable nucleoside phosphoramidase activity (PubMed 21754980, PubMed 15703176). The loss of hinT results in failure to grow in media containing 0.75 M KCl, 0.9 M NaCl, 0.5 M NaOAc, or 10 mM MnCl(2) (PubMed 15703176). {ECO 0000269|PubMed 15703176, ECO 0000269|PubMed 21754980}. # EcoGene EG12172 hinT # FUNCTION HINT_ECOLI Hydrolyzes purine nucleotide phosphoramidates, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate), guanosine 5'monophosphomorpholidate (GMP-morpholidate) and tryptamine 5'guanosine monophosphate (TpGd) (PubMed 15703176, PubMed 20934431). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha- acetyl lysine methyl ester)) generated by lysine--tRNA ligase, and lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) (PubMed 15703176). Is essential for the activity of the enzyme D- alanine dehydrogenase (DadA) and is required for E.coli to grow on D-alanine as a sole carbon source (PubMed 21754980). Is also required for growth at high salt concentrations (PubMed 15703176). {ECO 0000269|PubMed 15703176, ECO 0000269|PubMed 20934431, ECO 0000269|PubMed 21754980}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000166 nucleotide binding; IEA:UniProtKB-KW. # GO_function GO:0043530 adenosine 5'-monophosphoramidase activity; IDA:EcoCyc. # GO_process GO:0055130 D-alanine catabolic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # Gene3D 3.30.428.10 -; 1. # IntAct P0ACE7 14 # InterPro IPR001310 Histidine_triad_HIT # InterPro IPR011146 HIT-like # InterPro IPR019808 Histidine_triad_CS # Organism HINT_ECOLI Escherichia coli (strain K12) # PANTHER PTHR23089 PTHR23089 # PATRIC 32117449 VBIEscCol129921_1147 # PDB 3N1S X-ray; 1.45 A; A/B/E/F/I/J/M/N=1-119 # PDB 3N1T X-ray; 1.72 A; A/B/E/F=1-119 # PIR JC5685 JC5685 # PRINTS PR00332 HISTRIAD # PROSITE PS00892 HIT_1 # PROSITE PS51084 HIT_2 # Pfam PF01230 HIT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Purine nucleoside phosphoramidase {ECO:0000303|PubMed 15703176} # RefSeq NP_415621 NC_000913.3 # RefSeq WP_000807125 NZ_LN832404.1 # SIMILARITY Belongs to the HINT family. {ECO 0000305}. # SIMILARITY Contains 1 HIT domain. {ECO:0000255|PROSITE- ProRule PRU00464}. # SUBUNIT HINT_ECOLI Homodimer. {ECO 0000269|PubMed 15703176, ECO 0000269|PubMed 20934431}. # SUPFAM SSF54197 SSF54197 # eggNOG COG0537 LUCA # eggNOG ENOG4105K59 Bacteria BLAST swissprot:HINT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HINT_ECOLI BioCyc ECOL316407:JW1089-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1089-MONOMER BioCyc EcoCyc:EG12172-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12172-MONOMER BioCyc MetaCyc:EG12172-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12172-MONOMER COG COG0537 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0537 DIP DIP-48009N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48009N DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1016/j.jmb.2010.09.066 http://dx.doi.org/10.1016/j.jmb.2010.09.066 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M500434200 http://dx.doi.org/10.1074/jbc.M500434200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1990.tb00609.x http://dx.doi.org/10.1111/j.1365-2958.1990.tb00609.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pone.0020897 http://dx.doi.org/10.1371/journal.pone.0020897 EC_number EC:3.9.1.- {ECO:0000269|PubMed:15703176, ECO:0000269|PubMed:20934431, ECO:0000269|PubMed:21754980} http://www.genome.jp/dbget-bin/www_bget?EC:3.9.1.- {ECO:0000269|PubMed:15703176, ECO:0000269|PubMed:20934431, ECO:0000269|PubMed:21754980} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X17615 http://www.ebi.ac.uk/ena/data/view/X17615 ENZYME 3.9.1.- {ECO:0000269|PubMed:15703176, ECO:0000269|PubMed:20934431, ECO:0000269|PubMed:21754980} http://enzyme.expasy.org/EC/3.9.1.- {ECO:0000269|PubMed:15703176, ECO:0000269|PubMed:20934431, ECO:0000269|PubMed:21754980} EchoBASE EB2090 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2090 EcoGene EG12172 http://www.ecogene.org/geneInfo.php?eg_id=EG12172 EnsemblBacteria AAC74187 http://www.ensemblgenomes.org/id/AAC74187 EnsemblBacteria AAC74187 http://www.ensemblgenomes.org/id/AAC74187 EnsemblBacteria BAA35910 http://www.ensemblgenomes.org/id/BAA35910 EnsemblBacteria BAA35910 http://www.ensemblgenomes.org/id/BAA35910 EnsemblBacteria BAA35910 http://www.ensemblgenomes.org/id/BAA35910 EnsemblBacteria b1103 http://www.ensemblgenomes.org/id/b1103 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000166 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000166 GO_function GO:0043530 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043530 GO_process GO:0055130 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055130 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 3.30.428.10 http://www.cathdb.info/version/latest/superfamily/3.30.428.10 GeneID 948549 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948549 HOGENOM HOG000061064 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000061064&db=HOGENOM6 InParanoid P0ACE7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACE7 IntAct P0ACE7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACE7* IntEnz 3.9.1.- {ECO:0000269|PubMed:15703176, ECO:0000269|PubMed:20934431, ECO:0000269|PubMed:21754980} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.9.1.- {ECO:0000269|PubMed:15703176, ECO:0000269|PubMed:20934431, ECO:0000269|PubMed:21754980} InterPro IPR001310 http://www.ebi.ac.uk/interpro/entry/IPR001310 InterPro IPR011146 http://www.ebi.ac.uk/interpro/entry/IPR011146 InterPro IPR019808 http://www.ebi.ac.uk/interpro/entry/IPR019808 KEGG_Gene ecj:JW1089 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1089 KEGG_Gene eco:b1103 http://www.genome.jp/dbget-bin/www_bget?eco:b1103 KEGG_Orthology KO:K12150 http://www.genome.jp/dbget-bin/www_bget?KO:K12150 MINT MINT-1266101 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1266101 OMA IPTTNDV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IPTTNDV PANTHER PTHR23089 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23089 PDB 3N1S http://www.ebi.ac.uk/pdbe-srv/view/entry/3N1S PDB 3N1T http://www.ebi.ac.uk/pdbe-srv/view/entry/3N1T PDBsum 3N1S http://www.ebi.ac.uk/pdbsum/3N1S PDBsum 3N1T http://www.ebi.ac.uk/pdbsum/3N1T PRINTS PR00332 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00332 PROSITE PS00892 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00892 PROSITE PS51084 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51084 PSORT swissprot:HINT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HINT_ECOLI PSORT-B swissprot:HINT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HINT_ECOLI PSORT2 swissprot:HINT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HINT_ECOLI Pfam PF01230 http://pfam.xfam.org/family/PF01230 Phobius swissprot:HINT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HINT_ECOLI PhylomeDB P0ACE7 http://phylomedb.org/?seqid=P0ACE7 ProteinModelPortal P0ACE7 http://www.proteinmodelportal.org/query/uniprot/P0ACE7 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 15703176 http://www.ncbi.nlm.nih.gov/pubmed/15703176 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20934431 http://www.ncbi.nlm.nih.gov/pubmed/20934431 PubMed 2162465 http://www.ncbi.nlm.nih.gov/pubmed/2162465 PubMed 21754980 http://www.ncbi.nlm.nih.gov/pubmed/21754980 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415621 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415621 RefSeq WP_000807125 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000807125 SMR P0ACE7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACE7 STRING 511145.b1103 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1103&targetmode=cogs STRING COG0537 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0537&targetmode=cogs SUPFAM SSF54197 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54197 UniProtKB HINT_ECOLI http://www.uniprot.org/uniprot/HINT_ECOLI UniProtKB-AC P0ACE7 http://www.uniprot.org/uniprot/P0ACE7 charge swissprot:HINT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HINT_ECOLI eggNOG COG0537 http://eggnogapi.embl.de/nog_data/html/tree/COG0537 eggNOG ENOG4105K59 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K59 epestfind swissprot:HINT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HINT_ECOLI garnier swissprot:HINT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HINT_ECOLI helixturnhelix swissprot:HINT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HINT_ECOLI hmoment swissprot:HINT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HINT_ECOLI iep swissprot:HINT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HINT_ECOLI inforesidue swissprot:HINT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HINT_ECOLI octanol swissprot:HINT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HINT_ECOLI pepcoil swissprot:HINT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HINT_ECOLI pepdigest swissprot:HINT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HINT_ECOLI pepinfo swissprot:HINT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HINT_ECOLI pepnet swissprot:HINT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HINT_ECOLI pepstats swissprot:HINT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HINT_ECOLI pepwheel swissprot:HINT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HINT_ECOLI pepwindow swissprot:HINT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HINT_ECOLI sigcleave swissprot:HINT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HINT_ECOLI ## Database ID URL or Descriptions # BioGrid 4262524 14 # EcoGene EG12243 gadX # FUNCTION GADX_ECOLI Positively regulates the expression of about fifteen genes involved in acid resistance such as gadA, gadB and gadC. Depending on the conditions (growth phase and medium), can repress gadW. {ECO 0000269|PubMed 11298273, ECO 0000269|PubMed 11976288, ECO 0000269|PubMed 12446650, ECO 0000269|PubMed 12730179, ECO 0000269|PubMed 14617649, ECO 0000269|PubMed 14702398}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0000987 core promoter proximal region sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IBA:GO_Central. # GO_process GO:0006351 transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.60 -; 1. # INDUCTION GADX_ECOLI Expression can be activated by RpoS and repressed by CRP, H-NS and GadW, depending on the conditions. {ECO 0000269|PubMed 11976288, ECO 0000269|PubMed 12446650, ECO 0000269|PubMed 12730179}. # IntAct P37639 6 # InterPro IPR009057 Homeodomain-like # InterPro IPR018060 HTH_AraC # InterPro IPR018062 HTH_AraC-typ_CS # InterPro IPR020449 Tscrpt_reg_HTH_AraC-type # MISCELLANEOUS GADX_ECOLI GadX and GadW are part of a complex system required for acid resistance via the regulation of gadA and gadBC. Many of the described circuits use mutants missing one of the network components. In the wild-type situation, however, many of the scenarios are not easily observed. # Organism GADX_ECOLI Escherichia coli (strain K12) # PATRIC 32122494 VBIEscCol129921_3625 # PIR S47736 S47736 # PRINTS PR00032 HTHARAC # PROSITE PS00041 HTH_ARAC_FAMILY_1 # PROSITE PS01124 HTH_ARAC_FAMILY_2 # Pfam PF12833 HTH_18 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GADX_ECOLI HTH-type transcriptional regulator GadX # RefSeq NP_417973 NC_000913.3 # RefSeq WP_001191059 NZ_LN832404.1 # SIMILARITY Contains 1 HTH araC/xylS-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00593}. # SMART SM00342 HTH_ARAC # SUBUNIT Homodimer. {ECO:0000269|PubMed 12446650}. # SUPFAM SSF46689 SSF46689 # eggNOG ENOG4108NKV Bacteria # eggNOG ENOG410XRJG LUCA BLAST swissprot:GADX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GADX_ECOLI BioCyc ECOL316407:JW3484-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3484-MONOMER BioCyc EcoCyc:EG12243-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12243-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2001.02358.x http://dx.doi.org/10.1046/j.1365-2958.2001.02358.x DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1099/mic.0.26659-0 http://dx.doi.org/10.1099/mic.0.26659-0 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.10.2603-2613.2002 http://dx.doi.org/10.1128/JB.184.10.2603-2613.2002 DOI 10.1128/JB.184.24.7001-7012.2002 http://dx.doi.org/10.1128/JB.184.24.7001-7012.2002 DOI 10.1128/JB.185.10.3190-3201.2003 http://dx.doi.org/10.1128/JB.185.10.3190-3201.2003 DOI 10.1128/JB.185.23.6852-6859.2003 http://dx.doi.org/10.1128/JB.185.23.6852-6859.2003 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2154 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2154 EcoGene EG12243 http://www.ecogene.org/geneInfo.php?eg_id=EG12243 EnsemblBacteria AAC76541 http://www.ensemblgenomes.org/id/AAC76541 EnsemblBacteria AAC76541 http://www.ensemblgenomes.org/id/AAC76541 EnsemblBacteria BAE77778 http://www.ensemblgenomes.org/id/BAE77778 EnsemblBacteria BAE77778 http://www.ensemblgenomes.org/id/BAE77778 EnsemblBacteria BAE77778 http://www.ensemblgenomes.org/id/BAE77778 EnsemblBacteria b3516 http://www.ensemblgenomes.org/id/b3516 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000987 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000987 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 GeneID 948028 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948028 HOGENOM HOG000125870 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125870&db=HOGENOM6 InParanoid P37639 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37639 IntAct P37639 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37639* InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR018060 http://www.ebi.ac.uk/interpro/entry/IPR018060 InterPro IPR018062 http://www.ebi.ac.uk/interpro/entry/IPR018062 InterPro IPR020449 http://www.ebi.ac.uk/interpro/entry/IPR020449 KEGG_Gene ecj:JW3484 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3484 KEGG_Gene eco:b3516 http://www.genome.jp/dbget-bin/www_bget?eco:b3516 OMA NCGPAAS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NCGPAAS PRINTS PR00032 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00032 PROSITE PS00041 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00041 PROSITE PS01124 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01124 PSORT swissprot:GADX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GADX_ECOLI PSORT-B swissprot:GADX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GADX_ECOLI PSORT2 swissprot:GADX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GADX_ECOLI Pfam PF12833 http://pfam.xfam.org/family/PF12833 Phobius swissprot:GADX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GADX_ECOLI PhylomeDB P37639 http://phylomedb.org/?seqid=P37639 ProteinModelPortal P37639 http://www.proteinmodelportal.org/query/uniprot/P37639 PubMed 11298273 http://www.ncbi.nlm.nih.gov/pubmed/11298273 PubMed 11976288 http://www.ncbi.nlm.nih.gov/pubmed/11976288 PubMed 12446650 http://www.ncbi.nlm.nih.gov/pubmed/12446650 PubMed 12730179 http://www.ncbi.nlm.nih.gov/pubmed/12730179 PubMed 14617649 http://www.ncbi.nlm.nih.gov/pubmed/14617649 PubMed 14702398 http://www.ncbi.nlm.nih.gov/pubmed/14702398 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417973 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417973 RefSeq WP_001191059 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001191059 SMART SM00342 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00342 SMR P37639 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37639 STRING 511145.b3516 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3516&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 UniProtKB GADX_ECOLI http://www.uniprot.org/uniprot/GADX_ECOLI UniProtKB-AC P37639 http://www.uniprot.org/uniprot/P37639 charge swissprot:GADX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GADX_ECOLI eggNOG ENOG4108NKV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108NKV eggNOG ENOG410XRJG http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRJG epestfind swissprot:GADX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GADX_ECOLI garnier swissprot:GADX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GADX_ECOLI helixturnhelix swissprot:GADX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GADX_ECOLI hmoment swissprot:GADX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GADX_ECOLI iep swissprot:GADX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GADX_ECOLI inforesidue swissprot:GADX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GADX_ECOLI octanol swissprot:GADX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GADX_ECOLI pepcoil swissprot:GADX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GADX_ECOLI pepdigest swissprot:GADX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GADX_ECOLI pepinfo swissprot:GADX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GADX_ECOLI pepnet swissprot:GADX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GADX_ECOLI pepstats swissprot:GADX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GADX_ECOLI pepwheel swissprot:GADX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GADX_ECOLI pepwindow swissprot:GADX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GADX_ECOLI sigcleave swissprot:GADX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GADX_ECOLI ## Database ID URL or Descriptions # BioGrid 4261840 25 # CDD cd00865 PEBP_bact_arch # EcoGene EG11238 ybhB # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GOslim_component GO:0005737 cytoplasm # Gene3D 3.90.280.10 -; 1. # IntAct P12994 6 # InterPro IPR005247 YbhB_YbcL # InterPro IPR008914 PEBP # Organism YBHB_ECOLI Escherichia coli (strain K12) # PATRIC 32116747 VBIEscCol129921_0799 # PDB 1FJJ X-ray; 1.66 A; A=1-158 # PDB 1VI3 X-ray; 1.76 A; A=2-158 # PIR E64813 Q3ECBA # Pfam PF01161 PBP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBHB_ECOLI UPF0098 protein YbhB # RefSeq NP_415294 NC_000913.3 # RefSeq WP_000767389 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0098 family. {ECO 0000305}. # SUBCELLULAR LOCATION YBHB_ECOLI Cytoplasm. # SUBUNIT YBHB_ECOLI Homodimer. # SUPFAM SSF49777 SSF49777 # TIGRFAMs TIGR00481 TIGR00481 # eggNOG COG1881 LUCA # eggNOG ENOG4108V1U Bacteria BLAST swissprot:YBHB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBHB_ECOLI BioCyc ECOL316407:JW0756-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0756-MONOMER BioCyc EcoCyc:EG11238-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11238-MONOMER COG COG1881 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1881 DOI 10.1006/jmbi.2001.4784 http://dx.doi.org/10.1006/jmbi.2001.4784 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J04423 http://www.ebi.ac.uk/ena/data/view/J04423 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1220 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1220 EcoGene EG11238 http://www.ecogene.org/geneInfo.php?eg_id=EG11238 EnsemblBacteria AAC73860 http://www.ensemblgenomes.org/id/AAC73860 EnsemblBacteria AAC73860 http://www.ensemblgenomes.org/id/AAC73860 EnsemblBacteria BAE76360 http://www.ensemblgenomes.org/id/BAE76360 EnsemblBacteria BAE76360 http://www.ensemblgenomes.org/id/BAE76360 EnsemblBacteria BAE76360 http://www.ensemblgenomes.org/id/BAE76360 EnsemblBacteria b0773 http://www.ensemblgenomes.org/id/b0773 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 Gene3D 3.90.280.10 http://www.cathdb.info/version/latest/superfamily/3.90.280.10 GeneID 945383 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945383 HOGENOM HOG000236247 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000236247&db=HOGENOM6 InParanoid P12994 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P12994 IntAct P12994 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P12994* InterPro IPR005247 http://www.ebi.ac.uk/interpro/entry/IPR005247 InterPro IPR008914 http://www.ebi.ac.uk/interpro/entry/IPR008914 KEGG_Gene ecj:JW0756 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0756 KEGG_Gene eco:b0773 http://www.genome.jp/dbget-bin/www_bget?eco:b0773 KEGG_Orthology KO:K06910 http://www.genome.jp/dbget-bin/www_bget?KO:K06910 OMA WHWIVAN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WHWIVAN PDB 1FJJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1FJJ PDB 1VI3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1VI3 PDBsum 1FJJ http://www.ebi.ac.uk/pdbsum/1FJJ PDBsum 1VI3 http://www.ebi.ac.uk/pdbsum/1VI3 PSORT swissprot:YBHB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBHB_ECOLI PSORT-B swissprot:YBHB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBHB_ECOLI PSORT2 swissprot:YBHB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBHB_ECOLI Pfam PF01161 http://pfam.xfam.org/family/PF01161 Phobius swissprot:YBHB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBHB_ECOLI PhylomeDB P12994 http://phylomedb.org/?seqid=P12994 ProteinModelPortal P12994 http://www.proteinmodelportal.org/query/uniprot/P12994 PubMed 11439028 http://www.ncbi.nlm.nih.gov/pubmed/11439028 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3058702 http://www.ncbi.nlm.nih.gov/pubmed/3058702 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415294 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415294 RefSeq WP_000767389 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000767389 SMR P12994 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P12994 STRING 511145.b0773 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0773&targetmode=cogs STRING COG1881 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1881&targetmode=cogs SUPFAM SSF49777 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49777 TIGRFAMs TIGR00481 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00481 UniProtKB YBHB_ECOLI http://www.uniprot.org/uniprot/YBHB_ECOLI UniProtKB-AC P12994 http://www.uniprot.org/uniprot/P12994 charge swissprot:YBHB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBHB_ECOLI eggNOG COG1881 http://eggnogapi.embl.de/nog_data/html/tree/COG1881 eggNOG ENOG4108V1U http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108V1U epestfind swissprot:YBHB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBHB_ECOLI garnier swissprot:YBHB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBHB_ECOLI helixturnhelix swissprot:YBHB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBHB_ECOLI hmoment swissprot:YBHB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBHB_ECOLI iep swissprot:YBHB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBHB_ECOLI inforesidue swissprot:YBHB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBHB_ECOLI octanol swissprot:YBHB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBHB_ECOLI pepcoil swissprot:YBHB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBHB_ECOLI pepdigest swissprot:YBHB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBHB_ECOLI pepinfo swissprot:YBHB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBHB_ECOLI pepnet swissprot:YBHB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBHB_ECOLI pepstats swissprot:YBHB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBHB_ECOLI pepwheel swissprot:YBHB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBHB_ECOLI pepwindow swissprot:YBHB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBHB_ECOLI sigcleave swissprot:YBHB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBHB_ECOLI ## Database ID URL or Descriptions # BioGrid 4259567 343 # DISRUPTION PHENOTYPE Disruption blocks the export of at least five twin-arginine-containing precursor proteins that are predicted to bind redox cofactors, and hence fold prior to translocation. Disruption does not affect the Sec pathway. {ECO:0000269|PubMed 9660752}. # EcoGene EG11479 tatC # FUNCTION TATC_ECOLI Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. {ECO 0000255|HAMAP- Rule MF_00902, ECO 0000269|PubMed 11922668, ECO 0000269|PubMed 14580344, ECO 0000269|PubMed 19666509, ECO 0000269|PubMed 20926683, ECO 0000269|PubMed 9660752}. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:EcoliWiki. # GO_component GO:0033281 TAT protein transport complex; IDA:EcoCyc. # GO_function GO:0008565 protein transporter activity; IMP:EcoliWiki. # GO_function GO:0009977 proton motive force dependent protein transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0043953 protein transport by the Tat complex; IDA:EcoCyc. # GO_process GO:0065002 intracellular protein transmembrane transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005622 intracellular # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008565 protein transporter activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0055085 transmembrane transport # HAMAP MF_00902 TatC # INDUCTION Constitutively expressed. {ECO:0000269|PubMed 11160116}. # INTERACTION TATC_ECOLI P69425 tatB; NbExp=3; IntAct=EBI-4411641, EBI-4411577; # IntAct P69423 4 # InterPro IPR002033 TatC # InterPro IPR019820 Sec-indep_translocase_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02044 M00336 Twin-arginine translocation (Tat) system # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko03060 Protein export # KEGG_Pathway ko03070 Bacterial secretion system # Organism TATC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30371:SF0 PTHR30371:SF0 # PATRIC 32123177 VBIEscCol129921_3954 # PIR H65188 H65188 # PIR S30728 S30728 # PRINTS PR01840 TATCFAMILY # PROSITE PS01218 TATC # Pfam PF00902 TatC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Sec-independent protein translocase protein TatC {ECO:0000255|HAMAP-Rule MF_00902} # RefSeq NP_418282 NC_000913.3 # RefSeq WP_000109943 NZ_LN832404.1 # SIMILARITY Belongs to the TatC family. {ECO:0000255|HAMAP- Rule MF_00902}. # SUBCELLULAR LOCATION TATC_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_00902, ECO 0000269|PubMed 11591389, ECO 0000269|PubMed 15225613, ECO 0000269|PubMed 20169075}; Multi- pass membrane protein {ECO 0000255|HAMAP-Rule MF_00902, ECO 0000269|PubMed 11591389, ECO 0000269|PubMed 15225613, ECO 0000269|PubMed 20169075}. Note=Localizes at the cell poles. # SUBUNIT TATC_ECOLI The Tat system comprises two distinct complexes a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon. TatC can form a distinct, stable, multimeric complex independent of TatA and TatB. Each of TatA, TatB and TatC are able to interact in pairs without the third partner. Interacts with the signal sequence of DmsA and DmsD. {ECO 0000255|HAMAP-Rule MF_00902, ECO 0000269|PubMed 11279240, ECO 0000269|PubMed 15225613, ECO 0000269|PubMed 15571732, ECO 0000269|PubMed 15663945, ECO 0000269|PubMed 17686475, ECO 0000269|PubMed 20169075}. # TCDB 2.A.64.1 the twin arginine targeting (tat) family # TIGRFAMs TIGR00945 tatC # eggNOG COG0805 LUCA # eggNOG ENOG4105DCX Bacteria BLAST swissprot:TATC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TATC_ECOLI BioCyc ECOL316407:JW3815-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3815-MONOMER BioCyc EcoCyc:EG11479-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11479-MONOMER BioCyc MetaCyc:EG11479-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11479-MONOMER COG COG0805 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0805 DIP DIP-58537N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-58537N DOI 10.1006/jmbi.2002.5431 http://dx.doi.org/10.1006/jmbi.2002.5431 DOI 10.1016/S0014-5793(01)02904-0 http://dx.doi.org/10.1016/S0014-5793(01)02904-0 DOI 10.1016/S0092-8674(00)81149-6 http://dx.doi.org/10.1016/S0092-8674(00)81149-6 DOI 10.1016/S1097-2765(03)00398-8 http://dx.doi.org/10.1016/S1097-2765(03)00398-8 DOI 10.1016/j.febslet.2004.05.054 http://dx.doi.org/10.1016/j.febslet.2004.05.054 DOI 10.1016/j.febslet.2007.07.044 http://dx.doi.org/10.1016/j.febslet.2007.07.044 DOI 10.1016/j.jmb.2004.10.043 http://dx.doi.org/10.1016/j.jmb.2004.10.043 DOI 10.1016/j.jmb.2004.11.047 http://dx.doi.org/10.1016/j.jmb.2004.11.047 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2000.01719.x http://dx.doi.org/10.1046/j.1365-2958.2000.01719.x DOI 10.1046/j.1365-2958.2002.02853.x http://dx.doi.org/10.1046/j.1365-2958.2002.02853.x DOI 10.1073/pnas.052018199 http://dx.doi.org/10.1073/pnas.052018199 DOI 10.1073/pnas.0901566106 http://dx.doi.org/10.1073/pnas.0901566106 DOI 10.1074/jbc.273.29.18003 http://dx.doi.org/10.1074/jbc.273.29.18003 DOI 10.1074/jbc.M100682200 http://dx.doi.org/10.1074/jbc.M100682200 DOI 10.1074/jbc.M109135200 http://dx.doi.org/10.1074/jbc.M109135200 DOI 10.1091/mbc.E10-07-0585 http://dx.doi.org/10.1091/mbc.E10-07-0585 DOI 10.1093/emboj/17.13.3640 http://dx.doi.org/10.1093/emboj/17.13.3640 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.183.5.1801-1804.2001 http://dx.doi.org/10.1128/JB.183.5.1801-1804.2001 DOI 10.1371/journal.pone.0009225 http://dx.doi.org/10.1371/journal.pone.0009225 EMBL AF067848 http://www.ebi.ac.uk/ena/data/view/AF067848 EMBL AJ005830 http://www.ebi.ac.uk/ena/data/view/AJ005830 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1445 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1445 EcoGene EG11479 http://www.ecogene.org/geneInfo.php?eg_id=EG11479 EnsemblBacteria AAC76842 http://www.ensemblgenomes.org/id/AAC76842 EnsemblBacteria AAC76842 http://www.ensemblgenomes.org/id/AAC76842 EnsemblBacteria BAE77463 http://www.ensemblgenomes.org/id/BAE77463 EnsemblBacteria BAE77463 http://www.ensemblgenomes.org/id/BAE77463 EnsemblBacteria BAE77463 http://www.ensemblgenomes.org/id/BAE77463 EnsemblBacteria b3839 http://www.ensemblgenomes.org/id/b3839 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0033281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033281 GO_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GO_function GO:0009977 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009977 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0043953 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043953 GO_process GO:0065002 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0065002 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 948328 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948328 HAMAP MF_00902 http://hamap.expasy.org/unirule/MF_00902 HOGENOM HOG000245379 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000245379&db=HOGENOM6 InParanoid P69423 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P69423 IntAct P69423 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69423* InterPro IPR002033 http://www.ebi.ac.uk/interpro/entry/IPR002033 InterPro IPR019820 http://www.ebi.ac.uk/interpro/entry/IPR019820 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW3815 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3815 KEGG_Gene eco:b3839 http://www.genome.jp/dbget-bin/www_bget?eco:b3839 KEGG_Orthology KO:K03118 http://www.genome.jp/dbget-bin/www_bget?KO:K03118 KEGG_Pathway ko03060 http://www.genome.jp/kegg-bin/show_pathway?ko03060 KEGG_Pathway ko03070 http://www.genome.jp/kegg-bin/show_pathway?ko03070 MINT MINT-8083961 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8083961 OMA ATQIYKF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ATQIYKF PANTHER PTHR30371:SF0 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30371:SF0 PRINTS PR01840 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01840 PROSITE PS01218 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01218 PSORT swissprot:TATC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TATC_ECOLI PSORT-B swissprot:TATC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TATC_ECOLI PSORT2 swissprot:TATC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TATC_ECOLI Pfam PF00902 http://pfam.xfam.org/family/PF00902 Phobius swissprot:TATC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TATC_ECOLI PhylomeDB P69423 http://phylomedb.org/?seqid=P69423 ProteinModelPortal P69423 http://www.proteinmodelportal.org/query/uniprot/P69423 PubMed 10652088 http://www.ncbi.nlm.nih.gov/pubmed/10652088 PubMed 11160116 http://www.ncbi.nlm.nih.gov/pubmed/11160116 PubMed 11279240 http://www.ncbi.nlm.nih.gov/pubmed/11279240 PubMed 11591389 http://www.ncbi.nlm.nih.gov/pubmed/11591389 PubMed 11781311 http://www.ncbi.nlm.nih.gov/pubmed/11781311 PubMed 11867724 http://www.ncbi.nlm.nih.gov/pubmed/11867724 PubMed 11922668 http://www.ncbi.nlm.nih.gov/pubmed/11922668 PubMed 11952898 http://www.ncbi.nlm.nih.gov/pubmed/11952898 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 14580344 http://www.ncbi.nlm.nih.gov/pubmed/14580344 PubMed 15225613 http://www.ncbi.nlm.nih.gov/pubmed/15225613 PubMed 15571732 http://www.ncbi.nlm.nih.gov/pubmed/15571732 PubMed 15663945 http://www.ncbi.nlm.nih.gov/pubmed/15663945 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17686475 http://www.ncbi.nlm.nih.gov/pubmed/17686475 PubMed 19666509 http://www.ncbi.nlm.nih.gov/pubmed/19666509 PubMed 20169075 http://www.ncbi.nlm.nih.gov/pubmed/20169075 PubMed 20926683 http://www.ncbi.nlm.nih.gov/pubmed/20926683 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9546395 http://www.ncbi.nlm.nih.gov/pubmed/9546395 PubMed 9649434 http://www.ncbi.nlm.nih.gov/pubmed/9649434 PubMed 9660752 http://www.ncbi.nlm.nih.gov/pubmed/9660752 RefSeq NP_418282 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418282 RefSeq WP_000109943 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000109943 STRING 511145.b3839 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3839&targetmode=cogs STRING COG0805 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0805&targetmode=cogs TCDB 2.A.64.1 http://www.tcdb.org/search/result.php?tc=2.A.64.1 TIGRFAMs TIGR00945 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00945 UniProtKB TATC_ECOLI http://www.uniprot.org/uniprot/TATC_ECOLI UniProtKB-AC P69423 http://www.uniprot.org/uniprot/P69423 charge swissprot:TATC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TATC_ECOLI eggNOG COG0805 http://eggnogapi.embl.de/nog_data/html/tree/COG0805 eggNOG ENOG4105DCX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DCX epestfind swissprot:TATC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TATC_ECOLI garnier swissprot:TATC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TATC_ECOLI helixturnhelix swissprot:TATC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TATC_ECOLI hmoment swissprot:TATC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TATC_ECOLI iep swissprot:TATC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TATC_ECOLI inforesidue swissprot:TATC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TATC_ECOLI octanol swissprot:TATC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TATC_ECOLI pepcoil swissprot:TATC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TATC_ECOLI pepdigest swissprot:TATC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TATC_ECOLI pepinfo swissprot:TATC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TATC_ECOLI pepnet swissprot:TATC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TATC_ECOLI pepstats swissprot:TATC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TATC_ECOLI pepwheel swissprot:TATC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TATC_ECOLI pepwindow swissprot:TATC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TATC_ECOLI sigcleave swissprot:TATC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TATC_ECOLI ## Database ID URL or Descriptions # AltName KDTA_ECOLI Bifunctional Kdo transferase # AltName KDTA_ECOLI Kdo-lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase # AltName KDTA_ECOLI Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase # BIOPHYSICOCHEMICAL PROPERTIES KDTA_ECOLI Kinetic parameters KM=52 uM for lipid IV(A) (at pH 8) {ECO 0000269|PubMed 1577828}; KM=88 uM for CMP-Kdo (at pH 8) {ECO 0000269|PubMed 1577828}; Vmax=18 umol/min/mg enzyme (at pH 8) {ECO 0000269|PubMed 1577828}; pH dependence Optimum pH is 7. {ECO 0000269|PubMed 1577828}; # BRENDA 2.4.99.12 2026 # BRENDA 2.4.99.13 2026 # BioGrid 4263240 348 # CATALYTIC ACTIVITY KDTA_ECOLI Alpha-Kdo-(2->6)-lipid IV(A) + CMP-beta-Kdo = alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IV(A) + CMP. {ECO 0000269|PubMed 10951204, ECO 0000269|PubMed 1577828}. # CATALYTIC ACTIVITY KDTA_ECOLI Lipid IV(A) + CMP-beta-Kdo = alpha-Kdo-(2->6)- lipid IV(A) + CMP. {ECO 0000269|PubMed 10951204, ECO 0000269|PubMed 1577828}. # DISRUPTION PHENOTYPE Cells lacking this gene display growth defects, absence of Kdo transferase activity, and accumulate massive amounts of lipid IV(A). {ECO:0000269|PubMed 7499229}. # DOMAIN KDTA_ECOLI The N-terminal half of KdtA is responsible for determining the number of Kdo residues that are transferred to lipid IVA. {ECO 0000269|PubMed 20394418}. # ENZYME REGULATION Catalytic activity is inhibited by the antibiotic polymixin B and by Re endotoxin. {ECO:0000269|PubMed 1577828}. # EcoGene EG10520 waaA # FUNCTION KDTA_ECOLI Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of two 3-deoxy-D-manno-octulosonate (Kdo) residues from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide- 1,4'-bisphosphate precursor of lipid A. {ECO 0000269|PubMed 10951204, ECO 0000269|PubMed 1577828}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:EcoliWiki. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0016740 transferase activity; IDA:EcoCyc. # GO_process GO:0009244 lipopolysaccharide core region biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0009245 lipid A biosynthetic process; IMP:EcoliWiki. # GO_process GO:0036104 Kdo2-lipid A biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # IntAct P0AC75 16 # InterPro IPR001296 Glyco_trans_1 # InterPro IPR007507 Glycos_transf_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01003 Glycosyltransferases # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # KEGG_Pathway ko00540 Lipopolysaccharide biosynthesis # Organism KDTA_ECOLI Escherichia coli (strain K12) # PATHWAY Bacterial outer membrane biogenesis; LPS core biosynthesis. {ECO:0000269|PubMed 1577828}. # PATHWAY Glycolipid biosynthesis; KDO(2)-lipid A biosynthesis; KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A): step 1/4. {ECO 0000269|PubMed:1577828}. # PATHWAY Glycolipid biosynthesis; KDO(2)-lipid A biosynthesis; KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A): step 2/4. {ECO 0000269|PubMed:1577828}. # PATRIC 32122753 VBIEscCol129921_3753 # PIR JU0467 JU0467 # PTM KDTA_ECOLI Degraded by the protease FtsH; therefore FtsH regulates the addition of the sugar moiety to the LPS and thus the maturation of the LPS precursor. {ECO 0000269|PubMed 18776015}. # Pfam PF00534 Glycos_transf_1 # Pfam PF04413 Glycos_transf_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName KDTA_ECOLI 3-deoxy-D-manno-octulosonic acid transferase # RefSeq NP_418090 NC_000913.3 # RefSeq WP_000891564 NZ_LN832404.1 # SIMILARITY Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 30 subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION KDTA_ECOLI Cell inner membrane {ECO 0000305|PubMed 1577828}; Single-pass membrane protein {ECO 0000305|PubMed 1577828}; Cytoplasmic side {ECO 0000305|PubMed 1577828}. # UniPathway UPA00360 UER00483 # UniPathway UPA00360 UER00484 # eggNOG COG1519 LUCA # eggNOG ENOG4105D8A Bacteria BLAST swissprot:KDTA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:KDTA_ECOLI BioCyc ECOL316407:JW3608-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3608-MONOMER BioCyc EcoCyc:KDOTRANS-MONOMER http://biocyc.org/getid?id=EcoCyc:KDOTRANS-MONOMER BioCyc MetaCyc:KDOTRANS-MONOMER http://biocyc.org/getid?id=MetaCyc:KDOTRANS-MONOMER COG COG1519 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1519 DIP DIP-48036N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48036N DOI 10.1021/bi100343e http://dx.doi.org/10.1021/bi100343e DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1432-1327.2000.01619.x http://dx.doi.org/10.1046/j.1432-1327.2000.01619.x DOI 10.1074/jbc.270.46.27646 http://dx.doi.org/10.1074/jbc.270.46.27646 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00871-08 http://dx.doi.org/10.1128/JB.00871-08 EC_number EC:2.4.99.12 {ECO:0000269|PubMed:10951204, ECO:0000269|PubMed:1577828} http://www.genome.jp/dbget-bin/www_bget?EC:2.4.99.12 {ECO:0000269|PubMed:10951204, ECO:0000269|PubMed:1577828} EC_number EC:2.4.99.13 {ECO:0000269|PubMed:10951204, ECO:0000269|PubMed:1577828} http://www.genome.jp/dbget-bin/www_bget?EC:2.4.99.13 {ECO:0000269|PubMed:10951204, ECO:0000269|PubMed:1577828} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M60670 http://www.ebi.ac.uk/ena/data/view/M60670 EMBL M86305 http://www.ebi.ac.uk/ena/data/view/M86305 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.4.99.12 {ECO:0000269|PubMed:10951204, ECO:0000269|PubMed:1577828} http://enzyme.expasy.org/EC/2.4.99.12 {ECO:0000269|PubMed:10951204, ECO:0000269|PubMed:1577828} ENZYME 2.4.99.13 {ECO:0000269|PubMed:10951204, ECO:0000269|PubMed:1577828} http://enzyme.expasy.org/EC/2.4.99.13 {ECO:0000269|PubMed:10951204, ECO:0000269|PubMed:1577828} EchoBASE EB0515 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0515 EcoGene EG10520 http://www.ecogene.org/geneInfo.php?eg_id=EG10520 EnsemblBacteria AAC76657 http://www.ensemblgenomes.org/id/AAC76657 EnsemblBacteria AAC76657 http://www.ensemblgenomes.org/id/AAC76657 EnsemblBacteria BAE77659 http://www.ensemblgenomes.org/id/BAE77659 EnsemblBacteria BAE77659 http://www.ensemblgenomes.org/id/BAE77659 EnsemblBacteria BAE77659 http://www.ensemblgenomes.org/id/BAE77659 EnsemblBacteria b3633 http://www.ensemblgenomes.org/id/b3633 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0016740 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016740 GO_process GO:0009244 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009244 GO_process GO:0009245 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009245 GO_process GO:0036104 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036104 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 949048 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949048 HOGENOM HOG000257156 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000257156&db=HOGENOM6 InParanoid P0AC75 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AC75 IntAct P0AC75 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AC75* IntEnz 2.4.99.12 {ECO:0000269|PubMed:10951204, ECO:0000269|PubMed:1577828} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.99.12 {ECO:0000269|PubMed:10951204, ECO:0000269|PubMed:1577828} IntEnz 2.4.99.13 {ECO:0000269|PubMed:10951204, ECO:0000269|PubMed:1577828} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.99.13 {ECO:0000269|PubMed:10951204, ECO:0000269|PubMed:1577828} InterPro IPR001296 http://www.ebi.ac.uk/interpro/entry/IPR001296 InterPro IPR007507 http://www.ebi.ac.uk/interpro/entry/IPR007507 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01003 http://www.genome.jp/dbget-bin/www_bget?ko01003 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Gene ecj:JW3608 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3608 KEGG_Gene eco:b3633 http://www.genome.jp/dbget-bin/www_bget?eco:b3633 KEGG_Orthology KO:K02527 http://www.genome.jp/dbget-bin/www_bget?KO:K02527 KEGG_Pathway ko00540 http://www.genome.jp/kegg-bin/show_pathway?ko00540 KEGG_Reaction rn:R04658 http://www.genome.jp/dbget-bin/www_bget?rn:R04658 KEGG_Reaction rn:R05074 http://www.genome.jp/dbget-bin/www_bget?rn:R05074 KEGG_Reaction rn:R09763 http://www.genome.jp/dbget-bin/www_bget?rn:R09763 MINT MINT-1234738 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1234738 OMA KHGGHNP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KHGGHNP PSORT swissprot:KDTA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:KDTA_ECOLI PSORT-B swissprot:KDTA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:KDTA_ECOLI PSORT2 swissprot:KDTA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:KDTA_ECOLI Pfam PF00534 http://pfam.xfam.org/family/PF00534 Pfam PF04413 http://pfam.xfam.org/family/PF04413 Phobius swissprot:KDTA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:KDTA_ECOLI PhylomeDB P0AC75 http://phylomedb.org/?seqid=P0AC75 ProteinModelPortal P0AC75 http://www.proteinmodelportal.org/query/uniprot/P0AC75 PubMed 10951204 http://www.ncbi.nlm.nih.gov/pubmed/10951204 PubMed 1447141 http://www.ncbi.nlm.nih.gov/pubmed/1447141 PubMed 1577828 http://www.ncbi.nlm.nih.gov/pubmed/1577828 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18776015 http://www.ncbi.nlm.nih.gov/pubmed/18776015 PubMed 2033061 http://www.ncbi.nlm.nih.gov/pubmed/2033061 PubMed 20394418 http://www.ncbi.nlm.nih.gov/pubmed/20394418 PubMed 7499229 http://www.ncbi.nlm.nih.gov/pubmed/7499229 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418090 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418090 RefSeq WP_000891564 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000891564 SMR P0AC75 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AC75 STRING 511145.b3633 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3633&targetmode=cogs STRING COG1519 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1519&targetmode=cogs UniProtKB KDTA_ECOLI http://www.uniprot.org/uniprot/KDTA_ECOLI UniProtKB-AC P0AC75 http://www.uniprot.org/uniprot/P0AC75 charge swissprot:KDTA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:KDTA_ECOLI eggNOG COG1519 http://eggnogapi.embl.de/nog_data/html/tree/COG1519 eggNOG ENOG4105D8A http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D8A epestfind swissprot:KDTA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:KDTA_ECOLI garnier swissprot:KDTA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:KDTA_ECOLI helixturnhelix swissprot:KDTA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:KDTA_ECOLI hmoment swissprot:KDTA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:KDTA_ECOLI iep swissprot:KDTA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:KDTA_ECOLI inforesidue swissprot:KDTA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:KDTA_ECOLI octanol swissprot:KDTA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:KDTA_ECOLI pepcoil swissprot:KDTA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:KDTA_ECOLI pepdigest swissprot:KDTA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:KDTA_ECOLI pepinfo swissprot:KDTA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:KDTA_ECOLI pepnet swissprot:KDTA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:KDTA_ECOLI pepstats swissprot:KDTA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:KDTA_ECOLI pepwheel swissprot:KDTA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:KDTA_ECOLI pepwindow swissprot:KDTA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:KDTA_ECOLI sigcleave swissprot:KDTA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:KDTA_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES KHSE_ECOLI Kinetic parameters KM=0.14 mM for L-homoserine {ECO 0000269|PubMed 8973190}; KM=31.8 mM for D-homoserine {ECO 0000269|PubMed 8973190}; KM=0.13 mM for ATP {ECO 0000269|PubMed 8973190}; Note=The catalytic efficiency is 500-fold higher with L- homoserine than with D-homoserine as substrate.; # BioGrid 4261934 5 # CATALYTIC ACTIVITY ATP + L-homoserine = ADP + O-phospho-L- homoserine. {ECO:0000269|PubMed 8973190}. # EcoGene EG10999 thrB # FUNCTION KHSE_ECOLI Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate. Is also able to phosphorylate the hydroxy group on gamma-carbon of L-homoserine analogs when the functional group at the alpha-position is a carboxyl, an ester, or even a hydroxymethyl group. Neither L- threonine nor L-serine are substrates of the enzyme. {ECO 0000269|PubMed 8973190}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004413 homoserine kinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_process GO:0009086 methionine biosynthetic process; IBA:GO_Central. # GO_process GO:0009088 threonine biosynthetic process; IMP:EcoCyc. # GO_process GO:0009092 homoserine metabolic process; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.30.230.10 -; 1. # Gene3D 3.30.70.890 -; 1. # HAMAP MF_00384 Homoser_kinase # IntAct P00547 2 # InterPro IPR000870 Homoserine_kinase # InterPro IPR006203 GHMP_knse_ATP-bd_CS # InterPro IPR006204 GHMP_kinase_N_dom # InterPro IPR013750 GHMP_kinase_C_dom # InterPro IPR014721 Ribosomal_S5_D2-typ_fold_subgr # InterPro IPR020568 Ribosomal_S5_D2-typ_fold # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00260 Glycine, serine and threonine metabolism # Organism KHSE_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-threonine biosynthesis; L- threonine from L-aspartate step 4/5. # PATRIC 32115101 VBIEscCol129921_0002 # PIR S56630 KIECM # PIRSF PIRSF000676 Homoser_kin # PROSITE PS00627 GHMP_KINASES_ATP # Pfam PF00288 GHMP_kinases_N # Pfam PF08544 GHMP_kinases_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName KHSE_ECOLI Homoserine kinase # RefSeq NP_414544 NC_000913.3 # RefSeq WP_000241662 NZ_LN832404.1 # SIMILARITY Belongs to the GHMP kinase family. Homoserine kinase subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION KHSE_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF54211 SSF54211 # SUPFAM SSF55060 SSF55060 # TIGRFAMs TIGR00191 thrB # UniPathway UPA00050 UER00064 # eggNOG COG0083 LUCA # eggNOG ENOG4105D5I Bacteria BLAST swissprot:KHSE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:KHSE_ECOLI BioCyc ECOL316407:JW0002-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0002-MONOMER BioCyc EcoCyc:HOMOSERKIN-MONOMER http://biocyc.org/getid?id=EcoCyc:HOMOSERKIN-MONOMER BioCyc MetaCyc:HOMOSERKIN-MONOMER http://biocyc.org/getid?id=MetaCyc:HOMOSERKIN-MONOMER COG COG0083 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0083 DOI 10.1021/bi962203z http://dx.doi.org/10.1021/bi962203z DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1093/nar/9.2.339 http://dx.doi.org/10.1093/nar/9.2.339 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.39 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.39 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L13601 http://www.ebi.ac.uk/ena/data/view/L13601 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 2.7.1.39 http://enzyme.expasy.org/EC/2.7.1.39 EchoBASE EB0992 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0992 EcoGene EG10999 http://www.ecogene.org/geneInfo.php?eg_id=EG10999 EnsemblBacteria AAC73114 http://www.ensemblgenomes.org/id/AAC73114 EnsemblBacteria AAC73114 http://www.ensemblgenomes.org/id/AAC73114 EnsemblBacteria BAB96580 http://www.ensemblgenomes.org/id/BAB96580 EnsemblBacteria BAB96580 http://www.ensemblgenomes.org/id/BAB96580 EnsemblBacteria BAB96580 http://www.ensemblgenomes.org/id/BAB96580 EnsemblBacteria b0003 http://www.ensemblgenomes.org/id/b0003 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004413 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004413 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0009086 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009086 GO_process GO:0009088 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009088 GO_process GO:0009092 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009092 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.30.230.10 http://www.cathdb.info/version/latest/superfamily/3.30.230.10 Gene3D 3.30.70.890 http://www.cathdb.info/version/latest/superfamily/3.30.70.890 GeneID 947498 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947498 HAMAP MF_00384 http://hamap.expasy.org/unirule/MF_00384 HOGENOM HOG000247198 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000247198&db=HOGENOM6 InParanoid P00547 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00547 IntAct P00547 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00547* IntEnz 2.7.1.39 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.39 InterPro IPR000870 http://www.ebi.ac.uk/interpro/entry/IPR000870 InterPro IPR006203 http://www.ebi.ac.uk/interpro/entry/IPR006203 InterPro IPR006204 http://www.ebi.ac.uk/interpro/entry/IPR006204 InterPro IPR013750 http://www.ebi.ac.uk/interpro/entry/IPR013750 InterPro IPR014721 http://www.ebi.ac.uk/interpro/entry/IPR014721 InterPro IPR020568 http://www.ebi.ac.uk/interpro/entry/IPR020568 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0002 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0002 KEGG_Gene eco:b0003 http://www.genome.jp/dbget-bin/www_bget?eco:b0003 KEGG_Orthology KO:K00872 http://www.genome.jp/dbget-bin/www_bget?KO:K00872 KEGG_Pathway ko00260 http://www.genome.jp/kegg-bin/show_pathway?ko00260 KEGG_Reaction rn:R01771 http://www.genome.jp/dbget-bin/www_bget?rn:R01771 OMA FVHICKV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FVHICKV PROSITE PS00627 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00627 PSORT swissprot:KHSE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:KHSE_ECOLI PSORT-B swissprot:KHSE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:KHSE_ECOLI PSORT2 swissprot:KHSE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:KHSE_ECOLI Pfam PF00288 http://pfam.xfam.org/family/PF00288 Pfam PF08544 http://pfam.xfam.org/family/PF08544 Phobius swissprot:KHSE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:KHSE_ECOLI PhylomeDB P00547 http://phylomedb.org/?seqid=P00547 ProteinModelPortal P00547 http://www.proteinmodelportal.org/query/uniprot/P00547 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6259626 http://www.ncbi.nlm.nih.gov/pubmed/6259626 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8973190 http://www.ncbi.nlm.nih.gov/pubmed/8973190 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414544 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414544 RefSeq WP_000241662 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000241662 SMR P00547 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00547 STRING 511145.b0003 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0003&targetmode=cogs STRING COG0083 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0083&targetmode=cogs SUPFAM SSF54211 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54211 SUPFAM SSF55060 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55060 SWISS-2DPAGE P00547 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P00547 TIGRFAMs TIGR00191 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00191 UniProtKB KHSE_ECOLI http://www.uniprot.org/uniprot/KHSE_ECOLI UniProtKB-AC P00547 http://www.uniprot.org/uniprot/P00547 charge swissprot:KHSE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:KHSE_ECOLI eggNOG COG0083 http://eggnogapi.embl.de/nog_data/html/tree/COG0083 eggNOG ENOG4105D5I http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D5I epestfind swissprot:KHSE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:KHSE_ECOLI garnier swissprot:KHSE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:KHSE_ECOLI helixturnhelix swissprot:KHSE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:KHSE_ECOLI hmoment swissprot:KHSE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:KHSE_ECOLI iep swissprot:KHSE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:KHSE_ECOLI inforesidue swissprot:KHSE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:KHSE_ECOLI octanol swissprot:KHSE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:KHSE_ECOLI pepcoil swissprot:KHSE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:KHSE_ECOLI pepdigest swissprot:KHSE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:KHSE_ECOLI pepinfo swissprot:KHSE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:KHSE_ECOLI pepnet swissprot:KHSE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:KHSE_ECOLI pepstats swissprot:KHSE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:KHSE_ECOLI pepwheel swissprot:KHSE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:KHSE_ECOLI pepwindow swissprot:KHSE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:KHSE_ECOLI sigcleave swissprot:KHSE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:KHSE_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES MAO1_ECOLI Kinetic parameters KM=0.420 mM for L-malate {ECO 0000269|PubMed 17215140, ECO 0000269|PubMed 17557829}; KM=0.66 mM for L-malate {ECO 0000269|PubMed 17215140, ECO 0000269|PubMed 17557829}; KM=0.097 mM for NAD(+) {ECO 0000269|PubMed 17215140, ECO 0000269|PubMed 17557829}; KM=0.0688 mM for NAD(+) {ECO 0000269|PubMed 17215140, ECO 0000269|PubMed 17557829}; KM=2.59 mM for pyruvate {ECO 0000269|PubMed 17215140, ECO 0000269|PubMed 17557829}; Vmax=125.47 umol/min/mg enzyme {ECO 0000269|PubMed 17215140, ECO 0000269|PubMed 17557829}; Note=At pH 7.2.; pH dependence Optimum pH is 7.2 to 7.5 for L-malate. {ECO 0000269|PubMed 17215140, ECO 0000269|PubMed 17557829}; # BRENDA 1.1.1.38 2026 # BioGrid 4260208 266 # CATALYTIC ACTIVITY MAO1_ECOLI (S)-malate + NAD(+) = pyruvate + CO(2) + NADH. # CATALYTIC ACTIVITY MAO1_ECOLI Oxaloacetate = pyruvate + CO(2). # COFACTOR MAO1_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 17557829}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 17557829}; Note=Divalent metal cations. Prefers magnesium or manganese. {ECO 0000269|PubMed 17557829}; # ENZYME REGULATION MAO1_ECOLI Non-competitively inhibited by high concentrations of NAD(+) and L-malate. Also inhibited by CoA, acetyl-phosphate, palmitoyl-CoA, and oxaloacetate. Activated by aspartate. {ECO 0000269|PubMed 17215140, ECO 0000269|PubMed 17557829}. # EcoGene EG10948 maeA # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity; IDA:EcoCyc. # GO_function GO:0008948 oxaloacetate decarboxylase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051287 NAD binding; IEA:InterPro. # GO_process GO:0006094 gluconeogenesis; IMP:EcoCyc. # GO_process GO:0006108 malate metabolic process; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.10380 -; 1. # Gene3D 3.40.50.720 -; 1. # HAMAP MF_01619 NAD_malic_enz # IntAct P26616 3 # InterPro IPR001891 Malic_OxRdtase # InterPro IPR012301 Malic_N_dom # InterPro IPR012302 Malic_NAD-bd # InterPro IPR015884 Malic_enzyme_CS # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR023667 NAD_malic_enz_proteobac # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00620 Pyruvate metabolism # KEGG_Pathway ko02020 Two-component system # MISCELLANEOUS MAO1_ECOLI Can also use NADP(+) but is more effective with NAD(+). # Organism MAO1_ECOLI Escherichia coli (strain K12) # PATRIC 32118252 VBIEscCol129921_1546 # PIR B64901 B64901 # PIRSF PIRSF000106 ME # PRINTS PR00072 MALOXRDTASE # PROSITE PS00331 MALIC_ENZYMES # Pfam PF00390 malic # Pfam PF03949 Malic_M # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MAO1_ECOLI NAD-dependent malic enzyme # RefSeq NP_415996 NC_000913.3 # RefSeq WP_000433476 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA39419.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA39419.1; Type=Miscellaneous discrepancy; Note=The sequence differs from position 433 onward for unknown reasons.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the malic enzymes family. {ECO 0000305}. # SMART SM00919 Malic_M # SMART SM01274 malic # SUBUNIT Homotetramer. {ECO:0000269|PubMed 17557829}. # SUPFAM SSF51735 SSF51735 # eggNOG COG0281 LUCA # eggNOG ENOG4107R1I Bacteria BLAST swissprot:MAO1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MAO1_ECOLI BioCyc ECOL316407:JW5238-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5238-MONOMER BioCyc EcoCyc:MALIC-NAD-MONOMER http://biocyc.org/getid?id=EcoCyc:MALIC-NAD-MONOMER BioCyc MetaCyc:MALIC-NAD-MONOMER http://biocyc.org/getid?id=MetaCyc:MALIC-NAD-MONOMER COG COG0281 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0281 DOI 10.1016/j.pep.2006.11.017 http://dx.doi.org/10.1016/j.pep.2006.11.017 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00428-07 http://dx.doi.org/10.1128/JB.00428-07 EC_number EC:1.1.1.38 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.38 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X55956 http://www.ebi.ac.uk/ena/data/view/X55956 ENZYME 1.1.1.38 http://enzyme.expasy.org/EC/1.1.1.38 EchoBASE EB0941 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0941 EcoGene EG10948 http://www.ecogene.org/geneInfo.php?eg_id=EG10948 EnsemblBacteria AAC74552 http://www.ensemblgenomes.org/id/AAC74552 EnsemblBacteria AAC74552 http://www.ensemblgenomes.org/id/AAC74552 EnsemblBacteria BAA15127 http://www.ensemblgenomes.org/id/BAA15127 EnsemblBacteria BAA15127 http://www.ensemblgenomes.org/id/BAA15127 EnsemblBacteria BAA15127 http://www.ensemblgenomes.org/id/BAA15127 EnsemblBacteria b1479 http://www.ensemblgenomes.org/id/b1479 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004471 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004471 GO_function GO:0008948 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008948 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051287 GO_process GO:0006094 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006094 GO_process GO:0006108 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006108 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.10380 http://www.cathdb.info/version/latest/superfamily/3.40.50.10380 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 946031 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946031 HAMAP MF_01619 http://hamap.expasy.org/unirule/MF_01619 HOGENOM HOG000042487 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000042487&db=HOGENOM6 InParanoid P26616 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P26616 IntAct P26616 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P26616* IntEnz 1.1.1.38 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.38 InterPro IPR001891 http://www.ebi.ac.uk/interpro/entry/IPR001891 InterPro IPR012301 http://www.ebi.ac.uk/interpro/entry/IPR012301 InterPro IPR012302 http://www.ebi.ac.uk/interpro/entry/IPR012302 InterPro IPR015884 http://www.ebi.ac.uk/interpro/entry/IPR015884 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR023667 http://www.ebi.ac.uk/interpro/entry/IPR023667 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5238 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5238 KEGG_Gene eco:b1479 http://www.genome.jp/dbget-bin/www_bget?eco:b1479 KEGG_Orthology KO:K00027 http://www.genome.jp/dbget-bin/www_bget?KO:K00027 KEGG_Pathway ko00620 http://www.genome.jp/kegg-bin/show_pathway?ko00620 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 KEGG_Reaction rn:R00214 http://www.genome.jp/dbget-bin/www_bget?rn:R00214 OMA LNDPMYM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LNDPMYM PRINTS PR00072 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00072 PROSITE PS00331 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00331 PSORT swissprot:MAO1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MAO1_ECOLI PSORT-B swissprot:MAO1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MAO1_ECOLI PSORT2 swissprot:MAO1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MAO1_ECOLI Pfam PF00390 http://pfam.xfam.org/family/PF00390 Pfam PF03949 http://pfam.xfam.org/family/PF03949 Phobius swissprot:MAO1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MAO1_ECOLI PhylomeDB P26616 http://phylomedb.org/?seqid=P26616 ProteinModelPortal P26616 http://www.proteinmodelportal.org/query/uniprot/P26616 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17215140 http://www.ncbi.nlm.nih.gov/pubmed/17215140 PubMed 17557829 http://www.ncbi.nlm.nih.gov/pubmed/17557829 PubMed 2199308 http://www.ncbi.nlm.nih.gov/pubmed/2199308 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415996 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415996 RefSeq WP_000433476 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000433476 SMART SM00919 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00919 SMART SM01274 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01274 SMR P26616 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P26616 STRING 511145.b1479 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1479&targetmode=cogs STRING COG0281 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0281&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB MAO1_ECOLI http://www.uniprot.org/uniprot/MAO1_ECOLI UniProtKB-AC P26616 http://www.uniprot.org/uniprot/P26616 charge swissprot:MAO1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MAO1_ECOLI eggNOG COG0281 http://eggnogapi.embl.de/nog_data/html/tree/COG0281 eggNOG ENOG4107R1I http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107R1I epestfind swissprot:MAO1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MAO1_ECOLI garnier swissprot:MAO1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MAO1_ECOLI helixturnhelix swissprot:MAO1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MAO1_ECOLI hmoment swissprot:MAO1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MAO1_ECOLI iep swissprot:MAO1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MAO1_ECOLI inforesidue swissprot:MAO1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MAO1_ECOLI octanol swissprot:MAO1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MAO1_ECOLI pepcoil swissprot:MAO1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MAO1_ECOLI pepdigest swissprot:MAO1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MAO1_ECOLI pepinfo swissprot:MAO1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MAO1_ECOLI pepnet swissprot:MAO1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MAO1_ECOLI pepstats swissprot:MAO1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MAO1_ECOLI pepwheel swissprot:MAO1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MAO1_ECOLI pepwindow swissprot:MAO1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MAO1_ECOLI sigcleave swissprot:MAO1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MAO1_ECOLI ## Database ID URL or Descriptions # AltName PRMB_ECOLI N5-glutamine methyltransferase PrmB # BRENDA 2.1.1.298 2026 # BioGrid 4261060 5 # CATALYTIC ACTIVITY S-adenosyl-L-methionine + [ribosomal protein L3]-L-glutamine = S-adenosyl-L-homocysteine + [ribosomal protein L3]-N(5)-methyl-L-glutamine. {ECO:0000269|PubMed 11847124}. # EcoGene EG12449 prmB # FUNCTION PRMB_ECOLI Specifically methylates the 50S ribosomal protein L3 on 'Gln-150'. Does not methylate the translation termination release factors RF1 and RF2. {ECO 0000269|PubMed 11847124}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003676 nucleic acid binding; IEA:InterPro. # GO_function GO:0008276 protein methyltransferase activity; IDA:UniProtKB. # GO_function GO:0008757 S-adenosylmethionine-dependent methyltransferase activity; IDA:UniProtKB. # GO_function GO:0009007 site-specific DNA-methyltransferase (adenine-specific) activity; IEA:InterPro. # GO_function GO:0036009 protein-glutamine N-methyltransferase activity; IDA:EcoCyc. # GO_process GO:0006479 protein methylation; IDA:UniProtKB. # GO_process GO:0018364 peptidyl-glutamine methylation; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0006464 cellular protein modification process # Gene3D 3.40.50.150 -; 1. # HAMAP MF_02125 L3_methyltr_PrmB # IntAct P39199 8 # InterPro IPR002052 DNA_methylase_N6_adenine_CS # InterPro IPR004556 Modification_methylase_HemK # InterPro IPR007848 Small_mtfrase_dom # InterPro IPR017127 Ribosome_L3_Gln-N5_MeTrfase # InterPro IPR029063 SAM-dependent_MTases # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # Organism PRMB_ECOLI Escherichia coli (strain K12) # PATRIC 32120033 VBIEscCol129921_2426 # PIR H65005 H65005 # PIRSF PIRSF037167 Mtase_YfcB_prd # Pfam PF05175 MTS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PRMB_ECOLI 50S ribosomal protein L3 glutamine methyltransferase # RefSeq NP_416833 NC_000913.3 # RefSeq WP_001300582 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=M33021; Type=Frameshift; Positions=214, 222; Evidence={ECO 0000305}; # SIMILARITY Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily. {ECO 0000305}. # SUPFAM SSF53335 SSF53335 # TIGRFAMs TIGR00536 hemK_fam # TIGRFAMs TIGR03533 L3_gln_methyl # eggNOG COG2890 LUCA # eggNOG ENOG4105C76 Bacteria BLAST swissprot:PRMB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PRMB_ECOLI BioCyc ECOL316407:JW5841-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5841-MONOMER BioCyc EcoCyc:EG12449-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12449-MONOMER BioCyc MetaCyc:EG12449-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12449-MONOMER COG COG2890 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2890 DIP DIP-11976N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11976N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2510313 http://dx.doi.org/10.1042/bj2510313 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/emboj/21.4.769 http://dx.doi.org/10.1093/emboj/21.4.769 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1099/00221287-136-2-353 http://dx.doi.org/10.1099/00221287-136-2-353 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.1.298 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.298 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M27714 http://www.ebi.ac.uk/ena/data/view/M27714 EMBL M33021 http://www.ebi.ac.uk/ena/data/view/M33021 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL Y00720 http://www.ebi.ac.uk/ena/data/view/Y00720 ENZYME 2.1.1.298 http://enzyme.expasy.org/EC/2.1.1.298 EchoBASE EB2343 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2343 EcoGene EG12449 http://www.ecogene.org/geneInfo.php?eg_id=EG12449 EnsemblBacteria AAC75390 http://www.ensemblgenomes.org/id/AAC75390 EnsemblBacteria AAC75390 http://www.ensemblgenomes.org/id/AAC75390 EnsemblBacteria BAA16188 http://www.ensemblgenomes.org/id/BAA16188 EnsemblBacteria BAA16188 http://www.ensemblgenomes.org/id/BAA16188 EnsemblBacteria BAA16188 http://www.ensemblgenomes.org/id/BAA16188 EnsemblBacteria b2330 http://www.ensemblgenomes.org/id/b2330 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003676 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003676 GO_function GO:0008276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008276 GO_function GO:0008757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008757 GO_function GO:0009007 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009007 GO_function GO:0036009 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036009 GO_process GO:0006479 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006479 GO_process GO:0018364 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018364 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 GeneID 946805 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946805 HAMAP MF_02125 http://hamap.expasy.org/unirule/MF_02125 HOGENOM HOG000076275 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000076275&db=HOGENOM6 InParanoid P39199 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39199 IntAct P39199 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39199* IntEnz 2.1.1.298 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.298 InterPro IPR002052 http://www.ebi.ac.uk/interpro/entry/IPR002052 InterPro IPR004556 http://www.ebi.ac.uk/interpro/entry/IPR004556 InterPro IPR007848 http://www.ebi.ac.uk/interpro/entry/IPR007848 InterPro IPR017127 http://www.ebi.ac.uk/interpro/entry/IPR017127 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW5841 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5841 KEGG_Gene eco:b2330 http://www.genome.jp/dbget-bin/www_bget?eco:b2330 KEGG_Orthology KO:K07320 http://www.genome.jp/dbget-bin/www_bget?KO:K07320 MINT MINT-1267343 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1267343 OMA VLVCEVG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VLVCEVG PSORT swissprot:PRMB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PRMB_ECOLI PSORT-B swissprot:PRMB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PRMB_ECOLI PSORT2 swissprot:PRMB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PRMB_ECOLI Pfam PF05175 http://pfam.xfam.org/family/PF05175 Phobius swissprot:PRMB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PRMB_ECOLI PhylomeDB P39199 http://phylomedb.org/?seqid=P39199 ProteinModelPortal P39199 http://www.proteinmodelportal.org/query/uniprot/P39199 PubMed 11847124 http://www.ncbi.nlm.nih.gov/pubmed/11847124 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2182772 http://www.ncbi.nlm.nih.gov/pubmed/2182772 PubMed 2969724 http://www.ncbi.nlm.nih.gov/pubmed/2969724 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416833 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416833 RefSeq WP_001300582 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300582 STRING 511145.b2330 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2330&targetmode=cogs STRING COG2890 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2890&targetmode=cogs SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 TIGRFAMs TIGR00536 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00536 TIGRFAMs TIGR03533 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03533 UniProtKB PRMB_ECOLI http://www.uniprot.org/uniprot/PRMB_ECOLI UniProtKB-AC P39199 http://www.uniprot.org/uniprot/P39199 charge swissprot:PRMB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PRMB_ECOLI eggNOG COG2890 http://eggnogapi.embl.de/nog_data/html/tree/COG2890 eggNOG ENOG4105C76 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C76 epestfind swissprot:PRMB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PRMB_ECOLI garnier swissprot:PRMB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PRMB_ECOLI helixturnhelix swissprot:PRMB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PRMB_ECOLI hmoment swissprot:PRMB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PRMB_ECOLI iep swissprot:PRMB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PRMB_ECOLI inforesidue swissprot:PRMB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PRMB_ECOLI octanol swissprot:PRMB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PRMB_ECOLI pepcoil swissprot:PRMB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PRMB_ECOLI pepdigest swissprot:PRMB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PRMB_ECOLI pepinfo swissprot:PRMB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PRMB_ECOLI pepnet swissprot:PRMB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PRMB_ECOLI pepstats swissprot:PRMB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PRMB_ECOLI pepwheel swissprot:PRMB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PRMB_ECOLI pepwindow swissprot:PRMB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PRMB_ECOLI sigcleave swissprot:PRMB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PRMB_ECOLI ## Database ID URL or Descriptions # AltName CROE_ECOLI Putative lambdoid prophage e14 transcriptional regulatory protein # BioGrid 4262850 17 # EcoGene EG14414 croE # GO_function GO:0003677 DNA binding; IEA:InterPro. # GOslim_function GO:0003677 DNA binding # Gene3D 1.10.260.40 -; 1. # InterPro IPR010982 Lambda_DNA-bd_dom # InterPro IPR031856 YdaS_antitoxin # MISCELLANEOUS CROE_ECOLI This protein is part of the e14 prophage present on the genomes of E.coli K12 MG1655 and W3110. # Organism CROE_ECOLI Escherichia coli (strain K12) # PATRIC 32117531 VBIEscCol129921_1188 # PIR G64859 G64859 # Pfam PF15943 YdaS_antitoxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Prophage transcriptional regulatory protein {ECO 0000305} # RefSeq NP_415664 NC_000913.3 # RefSeq WP_000649480 NZ_CP010440.1 # eggNOG ENOG41078CG Bacteria # eggNOG ENOG410ZGU6 LUCA BLAST swissprot:CROE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CROE_ECOLI BioCyc ECOL316407:JW5169-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5169-MONOMER BioCyc EcoCyc:G6590-MONOMER http://biocyc.org/getid?id=EcoCyc:G6590-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14414 http://www.ecogene.org/geneInfo.php?eg_id=EG14414 EnsemblBacteria AAC74230 http://www.ensemblgenomes.org/id/AAC74230 EnsemblBacteria AAC74230 http://www.ensemblgenomes.org/id/AAC74230 EnsemblBacteria BAA35972 http://www.ensemblgenomes.org/id/BAA35972 EnsemblBacteria BAA35972 http://www.ensemblgenomes.org/id/BAA35972 EnsemblBacteria BAA35972 http://www.ensemblgenomes.org/id/BAA35972 EnsemblBacteria b1146 http://www.ensemblgenomes.org/id/b1146 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 Gene3D 1.10.260.40 http://www.cathdb.info/version/latest/superfamily/1.10.260.40 GeneID 945720 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945720 HOGENOM HOG000068954 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000068954&db=HOGENOM6 InterPro IPR010982 http://www.ebi.ac.uk/interpro/entry/IPR010982 InterPro IPR031856 http://www.ebi.ac.uk/interpro/entry/IPR031856 KEGG_Gene ecj:JW5169 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5169 KEGG_Gene eco:b1146 http://www.genome.jp/dbget-bin/www_bget?eco:b1146 OMA KYREGSF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KYREGSF PSORT swissprot:CROE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CROE_ECOLI PSORT-B swissprot:CROE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CROE_ECOLI PSORT2 swissprot:CROE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CROE_ECOLI Pfam PF15943 http://pfam.xfam.org/family/PF15943 Phobius swissprot:CROE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CROE_ECOLI ProteinModelPortal P75975 http://www.proteinmodelportal.org/query/uniprot/P75975 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415664 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415664 RefSeq WP_000649480 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000649480 STRING 511145.b1146 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1146&targetmode=cogs UniProtKB CROE_ECOLI http://www.uniprot.org/uniprot/CROE_ECOLI UniProtKB-AC P75975 http://www.uniprot.org/uniprot/P75975 charge swissprot:CROE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CROE_ECOLI eggNOG ENOG41078CG http://eggnogapi.embl.de/nog_data/html/tree/ENOG41078CG eggNOG ENOG410ZGU6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZGU6 epestfind swissprot:CROE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CROE_ECOLI garnier swissprot:CROE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CROE_ECOLI helixturnhelix swissprot:CROE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CROE_ECOLI hmoment swissprot:CROE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CROE_ECOLI iep swissprot:CROE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CROE_ECOLI inforesidue swissprot:CROE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CROE_ECOLI octanol swissprot:CROE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CROE_ECOLI pepcoil swissprot:CROE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CROE_ECOLI pepdigest swissprot:CROE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CROE_ECOLI pepinfo swissprot:CROE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CROE_ECOLI pepnet swissprot:CROE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CROE_ECOLI pepstats swissprot:CROE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CROE_ECOLI pepwheel swissprot:CROE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CROE_ECOLI pepwindow swissprot:CROE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CROE_ECOLI sigcleave swissprot:CROE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CROE_ECOLI ## Database ID URL or Descriptions # EcoGene EG11274 trpL # FUNCTION LPW_ECOLI This protein is involved in control of the biosynthesis of tryptophan. # GO_process GO:0000162 tryptophan biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0008652 cellular amino acid biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0090357 regulation of tryptophan metabolic process; IDA:EcoCyc. # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # InterPro IPR013205 Leader_Trp_op # Organism LPW_ECOLI Escherichia coli (strain K12) # PIR A03589 LFECW # Pfam PF08255 Leader_Trp # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LPW_ECOLI Trp operon leader peptide # RefSeq NP_415781 NC_000913.3 BLAST swissprot:LPW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LPW_ECOLI BioCyc ECOL316407:JW1257-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1257-MONOMER BioCyc EcoCyc:EG11274-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11274-MONOMER DOI 10.1016/0022-2836(76)90317-X http://dx.doi.org/10.1016/0022-2836(76)90317-X DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.76.11.5524 http://dx.doi.org/10.1073/pnas.76.11.5524 DOI 10.1093/nar/21.23.5485 http://dx.doi.org/10.1093/nar/21.23.5485 DOI 10.1093/nar/9.24.6647 http://dx.doi.org/10.1093/nar/9.24.6647 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01714 http://www.ebi.ac.uk/ena/data/view/J01714 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1252 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1252 EcoGene EG11274 http://www.ecogene.org/geneInfo.php?eg_id=EG11274 EnsemblBacteria AAC74347 http://www.ensemblgenomes.org/id/AAC74347 EnsemblBacteria AAC74347 http://www.ensemblgenomes.org/id/AAC74347 EnsemblBacteria BAE76395 http://www.ensemblgenomes.org/id/BAE76395 EnsemblBacteria BAE76395 http://www.ensemblgenomes.org/id/BAE76395 EnsemblBacteria BAE76395 http://www.ensemblgenomes.org/id/BAE76395 EnsemblBacteria b1265 http://www.ensemblgenomes.org/id/b1265 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0000162 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000162 GO_process GO:0008652 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008652 GO_process GO:0090357 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090357 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 945856 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945856 InterPro IPR013205 http://www.ebi.ac.uk/interpro/entry/IPR013205 KEGG_Gene ecj:JW1257 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1257 KEGG_Gene eco:b1265 http://www.genome.jp/dbget-bin/www_bget?eco:b1265 KEGG_Orthology KO:K07802 http://www.genome.jp/dbget-bin/www_bget?KO:K07802 PSORT swissprot:LPW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LPW_ECOLI PSORT-B swissprot:LPW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LPW_ECOLI PSORT2 swissprot:LPW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LPW_ECOLI Pfam PF08255 http://pfam.xfam.org/family/PF08255 Phobius swissprot:LPW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LPW_ECOLI PubMed 118451 http://www.ncbi.nlm.nih.gov/pubmed/118451 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7038627 http://www.ncbi.nlm.nih.gov/pubmed/7038627 PubMed 7505428 http://www.ncbi.nlm.nih.gov/pubmed/7505428 PubMed 781271 http://www.ncbi.nlm.nih.gov/pubmed/781271 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415781 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415781 UniProtKB LPW_ECOLI http://www.uniprot.org/uniprot/LPW_ECOLI UniProtKB-AC P0AD92 http://www.uniprot.org/uniprot/P0AD92 charge swissprot:LPW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LPW_ECOLI epestfind swissprot:LPW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LPW_ECOLI garnier swissprot:LPW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LPW_ECOLI helixturnhelix swissprot:LPW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LPW_ECOLI hmoment swissprot:LPW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LPW_ECOLI iep swissprot:LPW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LPW_ECOLI inforesidue swissprot:LPW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LPW_ECOLI octanol swissprot:LPW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LPW_ECOLI pepcoil swissprot:LPW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LPW_ECOLI pepdigest swissprot:LPW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LPW_ECOLI pepinfo swissprot:LPW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LPW_ECOLI pepnet swissprot:LPW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LPW_ECOLI pepstats swissprot:LPW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LPW_ECOLI pepwheel swissprot:LPW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LPW_ECOLI pepwindow swissprot:LPW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LPW_ECOLI sigcleave swissprot:LPW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LPW_ECOLI ## Database ID URL or Descriptions # AltName PFLD_ECOLI Pyruvate formate-lyase 2 # BioGrid 4262065 2 # CATALYTIC ACTIVITY PFLD_ECOLI Acetyl-CoA + formate = CoA + pyruvate. # EcoGene EG11910 pflD # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0008861 formate C-acetyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016407 acetyltransferase activity; IBA:GO_Central. # GO_process GO:0008152 metabolic process; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0008150 biological_process # IntAct P32674 3 # InterPro IPR001150 Gly_radical # InterPro IPR004184 PFL_dom # InterPro IPR010098 PFL2/GDeHydtase_fam # InterPro IPR019777 Form_AcTrfase_GR_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00620 Pyruvate metabolism # KEGG_Pathway ko00640 Propanoate metabolism # KEGG_Pathway ko00650 Butanoate metabolism # Organism PFLD_ECOLI Escherichia coli (strain K12) # PATHWAY Fermentation; pyruvate fermentation; formate from pyruvate step 1/1. # PATRIC 32123423 VBIEscCol129921_4072 # PIR B65202 B65202 # PROSITE PS00850 GLY_RADICAL_1 # PROSITE PS51149 GLY_RADICAL_2 # PROSITE PS51554 PFL # Pfam PF01228 Gly_radical # Pfam PF02901 PFL-like # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PFLD_ECOLI Formate acetyltransferase 2 # RefSeq NP_418386 NC_000913.3 # RefSeq WP_000184811 NZ_LN832404.1 # SIMILARITY Contains 1 PFL domain. {ECO:0000255|PROSITE- ProRule PRU00887}. # SIMILARITY Contains 1 glycine radical domain. {ECO:0000255|PROSITE-ProRule PRU00493}. # SUBCELLULAR LOCATION PFLD_ECOLI Cytoplasm {ECO 0000250}. # TIGRFAMs TIGR01774 PFL2-3 # UniPathway UPA00920 UER00891 # eggNOG COG1882 LUCA # eggNOG ENOG4105C6N Bacteria BLAST swissprot:PFLD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PFLD_ECOLI BioCyc ECOL316407:JW3923-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3923-MONOMER BioCyc EcoCyc:EG11910-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11910-MONOMER COG COG1882 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1882 DIP DIP-10469N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10469N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1099/13500872-141-4-961 http://dx.doi.org/10.1099/13500872-141-4-961 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.54 http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.54 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.3.1.54 http://enzyme.expasy.org/EC/2.3.1.54 EchoBASE EB1854 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1854 EcoGene EG11910 http://www.ecogene.org/geneInfo.php?eg_id=EG11910 EnsemblBacteria AAC76933 http://www.ensemblgenomes.org/id/AAC76933 EnsemblBacteria AAC76933 http://www.ensemblgenomes.org/id/AAC76933 EnsemblBacteria BAE77360 http://www.ensemblgenomes.org/id/BAE77360 EnsemblBacteria BAE77360 http://www.ensemblgenomes.org/id/BAE77360 EnsemblBacteria BAE77360 http://www.ensemblgenomes.org/id/BAE77360 EnsemblBacteria b3951 http://www.ensemblgenomes.org/id/b3951 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008861 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008861 GO_function GO:0016407 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016407 GO_process GO:0008152 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008152 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 948454 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948454 HOGENOM HOG000274400 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000274400&db=HOGENOM6 InParanoid P32674 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32674 IntAct P32674 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32674* IntEnz 2.3.1.54 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.54 InterPro IPR001150 http://www.ebi.ac.uk/interpro/entry/IPR001150 InterPro IPR004184 http://www.ebi.ac.uk/interpro/entry/IPR004184 InterPro IPR010098 http://www.ebi.ac.uk/interpro/entry/IPR010098 InterPro IPR019777 http://www.ebi.ac.uk/interpro/entry/IPR019777 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3923 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3923 KEGG_Gene eco:b3951 http://www.genome.jp/dbget-bin/www_bget?eco:b3951 KEGG_Orthology KO:K00656 http://www.genome.jp/dbget-bin/www_bget?KO:K00656 KEGG_Pathway ko00620 http://www.genome.jp/kegg-bin/show_pathway?ko00620 KEGG_Pathway ko00640 http://www.genome.jp/kegg-bin/show_pathway?ko00640 KEGG_Pathway ko00650 http://www.genome.jp/kegg-bin/show_pathway?ko00650 KEGG_Reaction rn:R00212 http://www.genome.jp/dbget-bin/www_bget?rn:R00212 KEGG_Reaction rn:R06987 http://www.genome.jp/dbget-bin/www_bget?rn:R06987 OMA EDARDWS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EDARDWS PROSITE PS00850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00850 PROSITE PS51149 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51149 PROSITE PS51554 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51554 PSORT swissprot:PFLD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PFLD_ECOLI PSORT-B swissprot:PFLD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PFLD_ECOLI PSORT2 swissprot:PFLD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PFLD_ECOLI Pfam PF01228 http://pfam.xfam.org/family/PF01228 Pfam PF02901 http://pfam.xfam.org/family/PF02901 Phobius swissprot:PFLD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PFLD_ECOLI PhylomeDB P32674 http://phylomedb.org/?seqid=P32674 ProteinModelPortal P32674 http://www.proteinmodelportal.org/query/uniprot/P32674 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7773398 http://www.ncbi.nlm.nih.gov/pubmed/7773398 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418386 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418386 RefSeq WP_000184811 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000184811 SMR P32674 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32674 STRING 511145.b3951 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3951&targetmode=cogs STRING COG1882 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1882&targetmode=cogs TIGRFAMs TIGR01774 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01774 UniProtKB PFLD_ECOLI http://www.uniprot.org/uniprot/PFLD_ECOLI UniProtKB-AC P32674 http://www.uniprot.org/uniprot/P32674 charge swissprot:PFLD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PFLD_ECOLI eggNOG COG1882 http://eggnogapi.embl.de/nog_data/html/tree/COG1882 eggNOG ENOG4105C6N http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C6N epestfind swissprot:PFLD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PFLD_ECOLI garnier swissprot:PFLD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PFLD_ECOLI helixturnhelix swissprot:PFLD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PFLD_ECOLI hmoment swissprot:PFLD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PFLD_ECOLI iep swissprot:PFLD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PFLD_ECOLI inforesidue swissprot:PFLD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PFLD_ECOLI octanol swissprot:PFLD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PFLD_ECOLI pepcoil swissprot:PFLD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PFLD_ECOLI pepdigest swissprot:PFLD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PFLD_ECOLI pepinfo swissprot:PFLD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PFLD_ECOLI pepnet swissprot:PFLD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PFLD_ECOLI pepstats swissprot:PFLD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PFLD_ECOLI pepwheel swissprot:PFLD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PFLD_ECOLI pepwindow swissprot:PFLD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PFLD_ECOLI sigcleave swissprot:PFLD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PFLD_ECOLI ## Database ID URL or Descriptions # CAUTION There is no equivalent of this gene in strain K12 / MG1655. {ECO 0000305}. # FUNCTION INH15_ECOLI Involved in the transposition of the insertion sequence IS5. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # InterPro IPR002559 Transposase_11 # InterPro IPR008490 Transposase_InsH_N # Organism INH15_ECOLI Escherichia coli (strain K12) # Pfam PF01609 DDE_Tnp_1 # Pfam PF05598 DUF772 # RecName INH15_ECOLI Transposase InsH for insertion sequence element IS5-15 # RefSeq WP_000019403 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA04874.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the transposase 11 family. {ECO 0000305}. # eggNOG COG3039 LUCA # eggNOG ENOG4105F2I Bacteria BLAST swissprot:INH15_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INH15_ECOLI DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 EMBL AJ001620 http://www.ebi.ac.uk/ena/data/view/AJ001620 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EnsemblBacteria BAE77163 http://www.ensemblgenomes.org/id/BAE77163 EnsemblBacteria BAE77163 http://www.ensemblgenomes.org/id/BAE77163 EnsemblBacteria BAE77163 http://www.ensemblgenomes.org/id/BAE77163 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 InterPro IPR002559 http://www.ebi.ac.uk/interpro/entry/IPR002559 InterPro IPR008490 http://www.ebi.ac.uk/interpro/entry/IPR008490 KEGG_Gene ecj:JW5928 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5928 PSORT swissprot:INH15_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INH15_ECOLI PSORT-B swissprot:INH15_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INH15_ECOLI PSORT2 swissprot:INH15_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INH15_ECOLI Pfam PF01609 http://pfam.xfam.org/family/PF01609 Pfam PF05598 http://pfam.xfam.org/family/PF05598 Phobius swissprot:INH15_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INH15_ECOLI PhylomeDB P0CE62 http://phylomedb.org/?seqid=P0CE62 ProteinModelPortal P0CE62 http://www.proteinmodelportal.org/query/uniprot/P0CE62 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 RefSeq WP_000019403 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000019403 SMR P0CE62 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0CE62 STRING 511145.b3505 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3505&targetmode=cogs UniProtKB INH15_ECOLI http://www.uniprot.org/uniprot/INH15_ECOLI UniProtKB-AC P0CE62 http://www.uniprot.org/uniprot/P0CE62 charge swissprot:INH15_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INH15_ECOLI eggNOG COG3039 http://eggnogapi.embl.de/nog_data/html/tree/COG3039 eggNOG ENOG4105F2I http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F2I epestfind swissprot:INH15_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INH15_ECOLI garnier swissprot:INH15_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INH15_ECOLI helixturnhelix swissprot:INH15_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INH15_ECOLI hmoment swissprot:INH15_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INH15_ECOLI iep swissprot:INH15_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INH15_ECOLI inforesidue swissprot:INH15_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INH15_ECOLI octanol swissprot:INH15_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INH15_ECOLI pepcoil swissprot:INH15_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INH15_ECOLI pepdigest swissprot:INH15_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INH15_ECOLI pepinfo swissprot:INH15_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INH15_ECOLI pepnet swissprot:INH15_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INH15_ECOLI pepstats swissprot:INH15_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INH15_ECOLI pepwheel swissprot:INH15_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INH15_ECOLI pepwindow swissprot:INH15_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INH15_ECOLI sigcleave swissprot:INH15_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INH15_ECOLI ## Database ID URL or Descriptions # BRENDA 1.9.6 2165 # BioGrid 4262221 119 # CATALYTIC ACTIVITY NAPA_ECOLI Nitrite + acceptor = nitrate + reduced acceptor. # COFACTOR NAPA_ECOLI Name=Mo-bis(molybdopterin guanine dinucleotide); Xref=ChEBI CHEBI 60539; Evidence={ECO 0000250}; Note=Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit. {ECO 0000250}; # COFACTOR NAPA_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000250}; Note=Binds 1 [4Fe-4S] cluster. {ECO 0000250}; # EcoGene EG12067 napA # FUNCTION NAPA_ECOLI Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity). {ECO 0000250}. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:CACAO. # GO_component GO:0042597 periplasmic space; IDA:EcoCyc. # GO_function GO:0005506 iron ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008940 nitrate reductase activity; IDA:CACAO. # GO_function GO:0009055 electron carrier activity; IEA:UniProtKB-HAMAP. # GO_function GO:0030151 molybdenum ion binding; IDA:EcoCyc. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IDA:EcoCyc. # GO_process GO:0006777 Mo-molybdopterin cofactor biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0009061 anaerobic respiration; IGI:EcoliWiki. # GO_process GO:0042128 nitrate assimilation; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # GOslim_process GO:0071941 nitrogen cycle metabolic process # HAMAP MF_01630 Nitrate_reduct # INTERACTION NAPA_ECOLI P0A9I5 napD; NbExp=8; IntAct=EBI-554952, EBI-554985; # IntAct P33937 12 # InterPro IPR006311 TAT_signal # InterPro IPR006656 Mopterin_OxRdtase # InterPro IPR006657 MoPterin_dinucl-bd_dom # InterPro IPR006963 Mopterin_OxRdtase_4Fe-4S_dom # InterPro IPR009010 Asp_de-COase-like_dom # InterPro IPR010051 Periplasm_NO3_reductase_lsu # InterPro IPR019546 TAT_signal_bac_arc # InterPro IPR027467 MopterinOxRdtase_cofactor_BS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00910 Nitrogen metabolism # Organism NAPA_ECOLI Escherichia coli (strain K12) # PATRIC 32119771 VBIEscCol129921_2295 # PDB 2NYA X-ray; 2.50 A; A/F=37-828 # PDB 2PQ4 NMR; -; B=1-35 # PIR D64990 D64990 # PROSITE PS00551 MOLYBDOPTERIN_PROK_1 # PROSITE PS51318 TAT # PROSITE PS51669 4FE4S_MOW_BIS_MGD # PTM NAPA_ECOLI Exported by the Tat system. The position of the signal peptide cleavage has been experimentally proven. # Pfam PF00384 Molybdopterin # Pfam PF01568 Molydop_binding # Pfam PF04879 Molybdop_Fe4S4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NAPA_ECOLI Periplasmic nitrate reductase # RefSeq NP_416710 NC_000913.3 # RefSeq WP_000778061 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA16399.1; Type=Frameshift; Positions=19, 27; Evidence={ECO 0000305}; # SIMILARITY Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. {ECO 0000305}. # SIMILARITY Contains 1 4Fe-4S Mo/W bis-MGD-type domain. {ECO 0000305}. # SMART SM00926 Molybdop_Fe4S4 # SUBCELLULAR LOCATION NAPA_ECOLI Periplasm {ECO 0000269|PubMed 10234835}. # SUBUNIT Interacts with NapB. {ECO 0000250}. # SUPFAM SSF50692 SSF50692 # TIGRFAMs TIGR01409 TAT_signal_seq # TIGRFAMs TIGR01706 NAPA # eggNOG COG0243 LUCA # eggNOG ENOG4107QIW Bacteria BLAST swissprot:NAPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NAPA_ECOLI BioCyc ECOL316407:JW2194-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2194-MONOMER BioCyc EcoCyc:NAPA-MONOMER http://biocyc.org/getid?id=EcoCyc:NAPA-MONOMER BioCyc MetaCyc:NAPA-MONOMER http://biocyc.org/getid?id=MetaCyc:NAPA-MONOMER COG COG0243 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0243 DIP DIP-10304N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10304N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M610507200 http://dx.doi.org/10.1074/jbc.M610507200 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1111/j.1574-6968.1999.tb13564.x http://dx.doi.org/10.1111/j.1574-6968.1999.tb13564.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.7.99.4 http://www.genome.jp/dbget-bin/www_bget?EC:1.7.99.4 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00008 http://www.ebi.ac.uk/ena/data/view/U00008 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.7.99.4 http://enzyme.expasy.org/EC/1.7.99.4 EchoBASE EB1994 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1994 EcoGene EG12067 http://www.ecogene.org/geneInfo.php?eg_id=EG12067 EnsemblBacteria AAC75266 http://www.ensemblgenomes.org/id/AAC75266 EnsemblBacteria AAC75266 http://www.ensemblgenomes.org/id/AAC75266 EnsemblBacteria BAA15989 http://www.ensemblgenomes.org/id/BAA15989 EnsemblBacteria BAA15989 http://www.ensemblgenomes.org/id/BAA15989 EnsemblBacteria BAA15989 http://www.ensemblgenomes.org/id/BAA15989 EnsemblBacteria b2206 http://www.ensemblgenomes.org/id/b2206 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0008940 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008940 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0030151 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030151 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0006777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006777 GO_process GO:0009061 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009061 GO_process GO:0042128 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042128 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GOslim_process GO:0071941 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071941 GeneID 947093 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947093 HAMAP MF_01630 http://hamap.expasy.org/unirule/MF_01630 HOGENOM HOG000031441 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000031441&db=HOGENOM6 InParanoid P33937 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33937 IntAct P33937 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33937* IntEnz 1.7.99.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.7.99.4 InterPro IPR006311 http://www.ebi.ac.uk/interpro/entry/IPR006311 InterPro IPR006656 http://www.ebi.ac.uk/interpro/entry/IPR006656 InterPro IPR006657 http://www.ebi.ac.uk/interpro/entry/IPR006657 InterPro IPR006963 http://www.ebi.ac.uk/interpro/entry/IPR006963 InterPro IPR009010 http://www.ebi.ac.uk/interpro/entry/IPR009010 InterPro IPR010051 http://www.ebi.ac.uk/interpro/entry/IPR010051 InterPro IPR019546 http://www.ebi.ac.uk/interpro/entry/IPR019546 InterPro IPR027467 http://www.ebi.ac.uk/interpro/entry/IPR027467 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2194 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2194 KEGG_Gene eco:b2206 http://www.genome.jp/dbget-bin/www_bget?eco:b2206 KEGG_Orthology KO:K02567 http://www.genome.jp/dbget-bin/www_bget?KO:K02567 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Reaction rn:R00798 http://www.genome.jp/dbget-bin/www_bget?rn:R00798 KEGG_Reaction rn:R01106 http://www.genome.jp/dbget-bin/www_bget?rn:R01106 MINT MINT-1243254 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1243254 OMA EEYDLWM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EEYDLWM PDB 2NYA http://www.ebi.ac.uk/pdbe-srv/view/entry/2NYA PDB 2PQ4 http://www.ebi.ac.uk/pdbe-srv/view/entry/2PQ4 PDBsum 2NYA http://www.ebi.ac.uk/pdbsum/2NYA PDBsum 2PQ4 http://www.ebi.ac.uk/pdbsum/2PQ4 PROSITE PS00551 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00551 PROSITE PS51318 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51318 PROSITE PS51669 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51669 PSORT swissprot:NAPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NAPA_ECOLI PSORT-B swissprot:NAPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NAPA_ECOLI PSORT2 swissprot:NAPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NAPA_ECOLI Pfam PF00384 http://pfam.xfam.org/family/PF00384 Pfam PF01568 http://pfam.xfam.org/family/PF01568 Pfam PF04879 http://pfam.xfam.org/family/PF04879 Phobius swissprot:NAPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NAPA_ECOLI PhylomeDB P33937 http://phylomedb.org/?seqid=P33937 ProteinModelPortal P33937 http://www.proteinmodelportal.org/query/uniprot/P33937 PubMed 10234835 http://www.ncbi.nlm.nih.gov/pubmed/10234835 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17218314 http://www.ncbi.nlm.nih.gov/pubmed/17218314 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416710 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416710 RefSeq WP_000778061 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000778061 SMART SM00926 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00926 SMR P33937 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33937 STRING 511145.b2206 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2206&targetmode=cogs STRING COG0243 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0243&targetmode=cogs SUPFAM SSF50692 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50692 TIGRFAMs TIGR01409 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01409 TIGRFAMs TIGR01706 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01706 UniProtKB NAPA_ECOLI http://www.uniprot.org/uniprot/NAPA_ECOLI UniProtKB-AC P33937 http://www.uniprot.org/uniprot/P33937 charge swissprot:NAPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NAPA_ECOLI eggNOG COG0243 http://eggnogapi.embl.de/nog_data/html/tree/COG0243 eggNOG ENOG4107QIW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QIW epestfind swissprot:NAPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NAPA_ECOLI garnier swissprot:NAPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NAPA_ECOLI helixturnhelix swissprot:NAPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NAPA_ECOLI hmoment swissprot:NAPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NAPA_ECOLI iep swissprot:NAPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NAPA_ECOLI inforesidue swissprot:NAPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NAPA_ECOLI octanol swissprot:NAPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NAPA_ECOLI pepcoil swissprot:NAPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NAPA_ECOLI pepdigest swissprot:NAPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NAPA_ECOLI pepinfo swissprot:NAPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NAPA_ECOLI pepnet swissprot:NAPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NAPA_ECOLI pepstats swissprot:NAPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NAPA_ECOLI pepwheel swissprot:NAPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NAPA_ECOLI pepwindow swissprot:NAPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NAPA_ECOLI sigcleave swissprot:NAPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NAPA_ECOLI ## Database ID URL or Descriptions # AltName MAK_ECOLI D-fructose kinase # AltName MAK_ECOLI Manno(fructo)kinase # BIOPHYSICOCHEMICAL PROPERTIES MAK_ECOLI Kinetic parameters KM=1.3 mM for D-fructose (at 25 degrees Celsius and pH 7.6) {ECO 0000269|PubMed 15157072}; KM=1.8 mM for ATP (at 25 degrees Celsius and pH 7.6) {ECO 0000269|PubMed 15157072}; KM=59 mM for glucose (at 25 degrees Celsius and pH 7.6) {ECO 0000269|PubMed 15157072}; Note=Catalytic efficiency with D-fructose as substrate is 55- fold higher than that with D-glucose.; # BioGrid 4259818 3 # CATALYTIC ACTIVITY MAK_ECOLI ATP + D-fructose = ADP + D-fructose 6- phosphate. # EcoGene EG11288 mak # FUNCTION MAK_ECOLI Catalyzes the phosphorylation of fructose to fructose-6- P. Has also low level glucokinase activity in vitro. Is not able to phosphorylate D-ribose, D-mannitol, D-sorbitol, inositol, and L-threonine. {ECO 0000269|PubMed 11742072, ECO 0000269|PubMed 15157072}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004396 hexokinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0008865 fructokinase activity; IEA:UniProtKB-EC. # GO_process GO:0019318 hexose metabolic process; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0044281 small molecule metabolic process # IntAct P23917 2 # InterPro IPR000600 ROK # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00051 Fructose and mannose metabolism # KEGG_Pathway ko00500 Starch and sucrose metabolism # KEGG_Pathway ko00520 Amino sugar and nucleotide sugar metabolism # Organism MAK_ECOLI Escherichia coli (strain K12) # PATRIC 32115931 VBIEscCol129921_0407 # PIR B64768 B64768 # PROSITE PS01125 ROK # Pfam PF00480 ROK # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MAK_ECOLI Fructokinase # RefSeq NP_414928 NC_000913.3 # RefSeq WP_001219309 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18118.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ROK (NagC/XylR) family. {ECO 0000305}. # eggNOG COG1940 LUCA # eggNOG ENOG4105DKQ Bacteria BLAST swissprot:MAK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MAK_ECOLI BioCyc ECOL316407:JW0385-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0385-MONOMER BioCyc EcoCyc:EG11288-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11288-MONOMER BioCyc MetaCyc:EG11288-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11288-MONOMER COG COG0524 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0524 DIP DIP-11288N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11288N DOI 10.1021/bi049424m http://dx.doi.org/10.1021/bi049424m DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.211569798 http://dx.doi.org/10.1073/pnas.211569798 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.4 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.4 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M64787 http://www.ebi.ac.uk/ena/data/view/M64787 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EMBL X76979 http://www.ebi.ac.uk/ena/data/view/X76979 ENZYME 2.7.1.4 http://enzyme.expasy.org/EC/2.7.1.4 EchoBASE EB1265 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1265 EcoGene EG11288 http://www.ecogene.org/geneInfo.php?eg_id=EG11288 EnsemblBacteria AAC73497 http://www.ensemblgenomes.org/id/AAC73497 EnsemblBacteria AAC73497 http://www.ensemblgenomes.org/id/AAC73497 EnsemblBacteria BAE76175 http://www.ensemblgenomes.org/id/BAE76175 EnsemblBacteria BAE76175 http://www.ensemblgenomes.org/id/BAE76175 EnsemblBacteria BAE76175 http://www.ensemblgenomes.org/id/BAE76175 EnsemblBacteria b0394 http://www.ensemblgenomes.org/id/b0394 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004396 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004396 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008865 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008865 GO_process GO:0019318 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019318 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 949086 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949086 HOGENOM HOG000150087 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000150087&db=HOGENOM6 InParanoid P23917 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23917 IntAct P23917 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P23917* IntEnz 2.7.1.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.4 InterPro IPR000600 http://www.ebi.ac.uk/interpro/entry/IPR000600 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0385 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0385 KEGG_Gene eco:b0394 http://www.genome.jp/dbget-bin/www_bget?eco:b0394 KEGG_Orthology KO:K00847 http://www.genome.jp/dbget-bin/www_bget?KO:K00847 KEGG_Pathway ko00051 http://www.genome.jp/kegg-bin/show_pathway?ko00051 KEGG_Pathway ko00500 http://www.genome.jp/kegg-bin/show_pathway?ko00500 KEGG_Pathway ko00520 http://www.genome.jp/kegg-bin/show_pathway?ko00520 KEGG_Reaction rn:R00867 http://www.genome.jp/dbget-bin/www_bget?rn:R00867 KEGG_Reaction rn:R03920 http://www.genome.jp/dbget-bin/www_bget?rn:R03920 OMA LEAWYEA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LEAWYEA PROSITE PS01125 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01125 PSORT swissprot:MAK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MAK_ECOLI PSORT-B swissprot:MAK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MAK_ECOLI PSORT2 swissprot:MAK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MAK_ECOLI Pfam PF00480 http://pfam.xfam.org/family/PF00480 Phobius swissprot:MAK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MAK_ECOLI PhylomeDB P23917 http://phylomedb.org/?seqid=P23917 ProteinModelPortal P23917 http://www.proteinmodelportal.org/query/uniprot/P23917 PubMed 11742072 http://www.ncbi.nlm.nih.gov/pubmed/11742072 PubMed 15157072 http://www.ncbi.nlm.nih.gov/pubmed/15157072 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1744033 http://www.ncbi.nlm.nih.gov/pubmed/1744033 PubMed 8807285 http://www.ncbi.nlm.nih.gov/pubmed/8807285 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414928 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414928 RefSeq WP_001219309 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001219309 SMR P23917 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P23917 STRING 511145.b0394 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0394&targetmode=cogs STRING COG0524 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0524&targetmode=cogs UniProtKB MAK_ECOLI http://www.uniprot.org/uniprot/MAK_ECOLI UniProtKB-AC P23917 http://www.uniprot.org/uniprot/P23917 charge swissprot:MAK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MAK_ECOLI eggNOG COG1940 http://eggnogapi.embl.de/nog_data/html/tree/COG1940 eggNOG ENOG4105DKQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DKQ epestfind swissprot:MAK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MAK_ECOLI garnier swissprot:MAK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MAK_ECOLI helixturnhelix swissprot:MAK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MAK_ECOLI hmoment swissprot:MAK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MAK_ECOLI iep swissprot:MAK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MAK_ECOLI inforesidue swissprot:MAK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MAK_ECOLI octanol swissprot:MAK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MAK_ECOLI pepcoil swissprot:MAK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MAK_ECOLI pepdigest swissprot:MAK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MAK_ECOLI pepinfo swissprot:MAK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MAK_ECOLI pepnet swissprot:MAK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MAK_ECOLI pepstats swissprot:MAK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MAK_ECOLI pepwheel swissprot:MAK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MAK_ECOLI pepwindow swissprot:MAK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MAK_ECOLI sigcleave swissprot:MAK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MAK_ECOLI ## Database ID URL or Descriptions # BioGrid 4262240 16 # EcoGene EG10059 araH # FUNCTION ARAH_ECOLI Part of the binding-protein-dependent transport system for L-arabinose. Probably responsible for the translocation of the substrate across the membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IDA:EcoCyc. # GO_function GO:0005215 transporter activity; IEA:InterPro. # GO_process GO:0008643 carbohydrate transport; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006810 transport # InterPro IPR001851 ABC_transp_permease # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00213 L-Arabinose transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism ARAH_ECOLI Escherichia coli (strain K12) # PATRIC 32119123 VBIEscCol129921_1979 # PIR S01075 S01075 # Pfam PF02653 BPD_transp_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ARAH_ECOLI L-arabinose transport system permease protein AraH # RefSeq WP_000100205 NZ_LN832404.1 # RefSeq YP_026162 NC_000913.3 # SEQUENCE CAUTION Sequence=BAA15719.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA29478.1; Type=Erroneous initiation; Evidence={ECO 0000305}; Sequence=CAA48911.1; Type=Erroneous initiation; Evidence={ECO:0000305}; # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION ARAH_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # TCDB 3.A.1.2 the atp-binding cassette (abc) superfamily # eggNOG COG1172 LUCA # eggNOG ENOG4105CNN Bacteria BLAST swissprot:ARAH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARAH_ECOLI BioCyc ECOL316407:JW1887-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1887-MONOMER BioCyc EcoCyc:ARAH-MONOMER http://biocyc.org/getid?id=EcoCyc:ARAH-MONOMER BioCyc MetaCyc:ARAH-MONOMER http://biocyc.org/getid?id=MetaCyc:ARAH-MONOMER COG COG1172 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1172 DOI 10.1016/0022-2836(87)90607-3 http://dx.doi.org/10.1016/0022-2836(87)90607-3 DOI 10.1016/0378-1119(94)90316-6 http://dx.doi.org/10.1016/0378-1119(94)90316-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X06091 http://www.ebi.ac.uk/ena/data/view/X06091 EMBL X69160 http://www.ebi.ac.uk/ena/data/view/X69160 EchoBASE EB0057 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0057 EcoGene EG10059 http://www.ecogene.org/geneInfo.php?eg_id=EG10059 EnsemblBacteria AAT48138 http://www.ensemblgenomes.org/id/AAT48138 EnsemblBacteria AAT48138 http://www.ensemblgenomes.org/id/AAT48138 EnsemblBacteria BAA15719 http://www.ensemblgenomes.org/id/BAA15719 EnsemblBacteria BAA15719 http://www.ensemblgenomes.org/id/BAA15719 EnsemblBacteria BAA15719 http://www.ensemblgenomes.org/id/BAA15719 EnsemblBacteria b4460 http://www.ensemblgenomes.org/id/b4460 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_process GO:0008643 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008643 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948923 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948923 HOGENOM HOG000212232 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000212232&db=HOGENOM6 InParanoid P0AE26 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AE26 InterPro IPR001851 http://www.ebi.ac.uk/interpro/entry/IPR001851 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1887 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1887 KEGG_Gene eco:b4460 http://www.genome.jp/dbget-bin/www_bget?eco:b4460 KEGG_Orthology KO:K10538 http://www.genome.jp/dbget-bin/www_bget?KO:K10538 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA MNIDAFY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MNIDAFY PSORT swissprot:ARAH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARAH_ECOLI PSORT-B swissprot:ARAH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARAH_ECOLI PSORT2 swissprot:ARAH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARAH_ECOLI Pfam PF02653 http://pfam.xfam.org/family/PF02653 Phobius swissprot:ARAH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARAH_ECOLI PhylomeDB P0AE26 http://phylomedb.org/?seqid=P0AE26 ProteinModelPortal P0AE26 http://www.proteinmodelportal.org/query/uniprot/P0AE26 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2445996 http://www.ncbi.nlm.nih.gov/pubmed/2445996 PubMed 8045430 http://www.ncbi.nlm.nih.gov/pubmed/8045430 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000100205 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000100205 RefSeq YP_026162 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026162 STRING 511145.b4460 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4460&targetmode=cogs STRING COG1172 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1172&targetmode=cogs TCDB 3.A.1.2 http://www.tcdb.org/search/result.php?tc=3.A.1.2 UniProtKB ARAH_ECOLI http://www.uniprot.org/uniprot/ARAH_ECOLI UniProtKB-AC P0AE26 http://www.uniprot.org/uniprot/P0AE26 charge swissprot:ARAH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARAH_ECOLI eggNOG COG1172 http://eggnogapi.embl.de/nog_data/html/tree/COG1172 eggNOG ENOG4105CNN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CNN epestfind swissprot:ARAH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARAH_ECOLI garnier swissprot:ARAH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARAH_ECOLI helixturnhelix swissprot:ARAH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARAH_ECOLI hmoment swissprot:ARAH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARAH_ECOLI iep swissprot:ARAH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARAH_ECOLI inforesidue swissprot:ARAH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARAH_ECOLI octanol swissprot:ARAH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARAH_ECOLI pepcoil swissprot:ARAH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARAH_ECOLI pepdigest swissprot:ARAH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARAH_ECOLI pepinfo swissprot:ARAH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARAH_ECOLI pepnet swissprot:ARAH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARAH_ECOLI pepstats swissprot:ARAH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARAH_ECOLI pepwheel swissprot:ARAH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARAH_ECOLI pepwindow swissprot:ARAH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARAH_ECOLI sigcleave swissprot:ARAH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARAH_ECOLI ## Database ID URL or Descriptions # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG12543 yjgX # GO_component GO:0005886 plasma membrane; IBA:GO_Central. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0008484 sulfuric ester hydrolase activity; IEA:InterPro. # GO_function GO:0016776 phosphotransferase activity, phosphate group as acceptor; IBA:GO_Central. # GO_process GO:0009244 lipopolysaccharide core region biosynthetic process; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.720.10 -; 1. # InterPro IPR000917 Sulfatase_N # InterPro IPR017849 Alkaline_Pase-like_a/b/a # InterPro IPR017850 Alkaline_phosphatase_core # Organism YJGX_ECOLI Escherichia coli (strain K12) # PIR S56500 S56500 # PIR S56501 S56501 # Pfam PF00884 Sulfatase # Proteomes UP000000625 Chromosome # RecName YJGX_ECOLI Putative phosphoethanolamine transferase YjgX # SEQUENCE CAUTION Sequence=AAA97171.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAA97172.1; Type=Frameshift; Positions=Several; Evidence={ECO 0000305}; Sequence=U00096; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; # SIMILARITY Belongs to the phosphoethanolamine transferase family. {ECO 0000305}. # SUBCELLULAR LOCATION YJGX_ECOLI Cell membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. # SUPFAM SSF53649 SSF53649 BLAST swissprot:YJGX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJGX_ECOLI BioCyc EcoCyc:G7897-MONOMER http://biocyc.org/getid?id=EcoCyc:G7897-MONOMER BioCyc EcoCyc:G7898-MONOMER http://biocyc.org/getid?id=EcoCyc:G7898-MONOMER DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.-.- http://www.genome.jp/dbget-bin/www_bget?EC:2.7.-.- EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 2.7.-.- http://enzyme.expasy.org/EC/2.7.-.- EchoBASE EB2431 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2431 EcoGene EG12543 http://www.ecogene.org/geneInfo.php?eg_id=EG12543 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008484 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008484 GO_function GO:0016776 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016776 GO_process GO:0009244 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009244 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.720.10 http://www.cathdb.info/version/latest/superfamily/3.40.720.10 HOGENOM HOG000124492 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000124492&db=HOGENOM6 IntEnz 2.7 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7 InterPro IPR000917 http://www.ebi.ac.uk/interpro/entry/IPR000917 InterPro IPR017849 http://www.ebi.ac.uk/interpro/entry/IPR017849 InterPro IPR017850 http://www.ebi.ac.uk/interpro/entry/IPR017850 PSORT swissprot:YJGX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJGX_ECOLI PSORT-B swissprot:YJGX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJGX_ECOLI PSORT2 swissprot:YJGX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJGX_ECOLI Pfam PF00884 http://pfam.xfam.org/family/PF00884 Phobius swissprot:YJGX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJGX_ECOLI PhylomeDB P39349 http://phylomedb.org/?seqid=P39349 ProteinModelPortal P39349 http://www.proteinmodelportal.org/query/uniprot/P39349 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SUPFAM SSF53649 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53649 UniProtKB YJGX_ECOLI http://www.uniprot.org/uniprot/YJGX_ECOLI UniProtKB-AC P39349 http://www.uniprot.org/uniprot/P39349 charge swissprot:YJGX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJGX_ECOLI epestfind swissprot:YJGX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJGX_ECOLI garnier swissprot:YJGX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJGX_ECOLI helixturnhelix swissprot:YJGX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJGX_ECOLI hmoment swissprot:YJGX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJGX_ECOLI iep swissprot:YJGX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJGX_ECOLI inforesidue swissprot:YJGX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJGX_ECOLI octanol swissprot:YJGX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJGX_ECOLI pepcoil swissprot:YJGX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJGX_ECOLI pepdigest swissprot:YJGX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJGX_ECOLI pepinfo swissprot:YJGX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJGX_ECOLI pepnet swissprot:YJGX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJGX_ECOLI pepstats swissprot:YJGX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJGX_ECOLI pepwheel swissprot:YJGX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJGX_ECOLI pepwindow swissprot:YJGX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJGX_ECOLI sigcleave swissprot:YJGX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJGX_ECOLI ## Database ID URL or Descriptions # AltName FDOG_ECOLI Aerobic formate dehydrogenase major subunit # AltName FDOG_ECOLI FDH-Z subunit alpha # AltName FDOG_ECOLI Formate dehydrogenase-O subunit alpha # BioGrid 4263323 17 # CATALYTIC ACTIVITY FDOG_ECOLI Formate + NAD(+) = CO(2) + NADH. # COFACTOR FDOG_ECOLI Name=Mo-bis(molybdopterin guanine dinucleotide); Xref=ChEBI CHEBI 60539; Evidence={ECO 0000250}; Note=Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit. {ECO 0000250}; # COFACTOR FDOG_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000305}; Note=Binds 1 [4Fe-4S] cluster. {ECO 0000305}; # EcoGene EG11858 fdoG # FUNCTION FDOG_ECOLI Allows to use formate as major electron donor during aerobic respiration. Subunit alpha possibly forms the active site. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0009326 formate dehydrogenase complex; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_function GO:0008863 formate dehydrogenase (NAD+) activity; IEA:UniProtKB-EC. # GO_function GO:0009055 electron carrier activity; IEA:InterPro. # GO_function GO:0030151 molybdenum ion binding; IEA:InterPro. # GO_function GO:0036397 formate dehydrogenase (quinone) activity; IDA:EcoCyc. # GO_function GO:0043546 molybdopterin cofactor binding; IEA:InterPro. # GO_function GO:0047111 formate dehydrogenase (cytochrome-c-553) activity; IEA:InterPro. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0015944 formate oxidation; IDA:EcoCyc. # GO_process GO:0045333 cellular respiration; IEP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0006950 response to stress # GOslim_process GO:0044281 small molecule metabolic process # INTERACTION FDOG_ECOLI P13024 fdhE; NbExp=3; IntAct=EBI-368676, EBI-550129; # IntAct P32176 12 # InterPro IPR006311 TAT_signal # InterPro IPR006443 Formate-DH-alph_fdnG # InterPro IPR006655 Mopterin_OxRdtase_prok_CS # InterPro IPR006656 Mopterin_OxRdtase # InterPro IPR006657 MoPterin_dinucl-bd_dom # InterPro IPR006963 Mopterin_OxRdtase_4Fe-4S_dom # InterPro IPR009010 Asp_de-COase-like_dom # InterPro IPR027467 MopterinOxRdtase_cofactor_BS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00630 Glyoxylate and dicarboxylate metabolism # KEGG_Pathway ko00680 Methane metabolism # Organism FDOG_ECOLI Escherichia coli (strain K12) # PATRIC 32123295 VBIEscCol129921_4008 # PIR A65195 S40838 # PROSITE PS00551 MOLYBDOPTERIN_PROK_1 # PROSITE PS00932 MOLYBDOPTERIN_PROK_3 # PROSITE PS51318 TAT # PROSITE PS51669 4FE4S_MOW_BIS_MGD # PTM FDOG_ECOLI Exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven. # Pfam PF00384 Molybdopterin # Pfam PF01568 Molydop_binding # Pfam PF04879 Molybdop_Fe4S4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FDOG_ECOLI Formate dehydrogenase-O major subunit # RefSeq NP_418330 NC_000913.3 # SIMILARITY Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. {ECO 0000305}. # SIMILARITY Contains 1 4Fe-4S Mo/W bis-MGD-type domain. {ECO:0000255|PROSITE-ProRule PRU01004}. # SMART SM00926 Molybdop_Fe4S4 # SUBCELLULAR LOCATION FDOG_ECOLI Periplasm {ECO 0000305}. # SUBUNIT FDOG_ECOLI Formate dehydrogenase is a membrane-bound complex, formed by subunits alpha, beta and gamma. # SUPFAM SSF50692 SSF50692; 2 # TIGRFAMs TIGR01553 formate-DH-alph # eggNOG COG0243 LUCA # eggNOG ENOG4107QIW Bacteria BLAST swissprot:FDOG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FDOG_ECOLI BioCyc ECOL316407:JW3865-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3865-MONOMER BioCyc EcoCyc:FDOG-MONOMER http://biocyc.org/getid?id=EcoCyc:FDOG-MONOMER BioCyc MetaCyc:FDOG-MONOMER http://biocyc.org/getid?id=MetaCyc:FDOG-MONOMER COG COG0243 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0243 DIP DIP-9576N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9576N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M610507200 http://dx.doi.org/10.1074/jbc.M610507200 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.2.1.2 http://www.genome.jp/dbget-bin/www_bget?EC:1.2.1.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X87583 http://www.ebi.ac.uk/ena/data/view/X87583 ENZYME 1.2.1.2 http://enzyme.expasy.org/EC/1.2.1.2 EchoBASE EB1804 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1804 EcoGene EG11858 http://www.ecogene.org/geneInfo.php?eg_id=EG11858 EnsemblBacteria AAD13456 http://www.ensemblgenomes.org/id/AAD13456 EnsemblBacteria AAD13456 http://www.ensemblgenomes.org/id/AAD13456 EnsemblBacteria BAE77415 http://www.ensemblgenomes.org/id/BAE77415 EnsemblBacteria BAE77415 http://www.ensemblgenomes.org/id/BAE77415 EnsemblBacteria BAE77415 http://www.ensemblgenomes.org/id/BAE77415 EnsemblBacteria b3894 http://www.ensemblgenomes.org/id/b3894 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0009326 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009326 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0008863 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008863 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0030151 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030151 GO_function GO:0036397 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036397 GO_function GO:0043546 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043546 GO_function GO:0047111 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047111 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0015944 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015944 GO_process GO:0045333 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045333 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 948394 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948394 HOGENOM HOG000163271 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000163271&db=HOGENOM6 InParanoid P32176 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32176 IntAct P32176 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32176* IntEnz 1.2.1.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.2.1.2 InterPro IPR006311 http://www.ebi.ac.uk/interpro/entry/IPR006311 InterPro IPR006443 http://www.ebi.ac.uk/interpro/entry/IPR006443 InterPro IPR006655 http://www.ebi.ac.uk/interpro/entry/IPR006655 InterPro IPR006656 http://www.ebi.ac.uk/interpro/entry/IPR006656 InterPro IPR006657 http://www.ebi.ac.uk/interpro/entry/IPR006657 InterPro IPR006963 http://www.ebi.ac.uk/interpro/entry/IPR006963 InterPro IPR009010 http://www.ebi.ac.uk/interpro/entry/IPR009010 InterPro IPR027467 http://www.ebi.ac.uk/interpro/entry/IPR027467 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3865 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3865 KEGG_Gene eco:b3894 http://www.genome.jp/dbget-bin/www_bget?eco:b3894 KEGG_Orthology KO:K00123 http://www.genome.jp/dbget-bin/www_bget?KO:K00123 KEGG_Pathway ko00630 http://www.genome.jp/kegg-bin/show_pathway?ko00630 KEGG_Pathway ko00680 http://www.genome.jp/kegg-bin/show_pathway?ko00680 KEGG_Reaction rn:R00519 http://www.genome.jp/dbget-bin/www_bget?rn:R00519 MINT MINT-8047511 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8047511 OMA QYFEMMN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QYFEMMN PROSITE PS00551 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00551 PROSITE PS00932 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00932 PROSITE PS51318 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51318 PROSITE PS51669 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51669 PSORT swissprot:FDOG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FDOG_ECOLI PSORT-B swissprot:FDOG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FDOG_ECOLI PSORT2 swissprot:FDOG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FDOG_ECOLI Pfam PF00384 http://pfam.xfam.org/family/PF00384 Pfam PF01568 http://pfam.xfam.org/family/PF01568 Pfam PF04879 http://pfam.xfam.org/family/PF04879 Phobius swissprot:FDOG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FDOG_ECOLI PhylomeDB P32176 http://phylomedb.org/?seqid=P32176 ProteinModelPortal P32176 http://www.proteinmodelportal.org/query/uniprot/P32176 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17218314 http://www.ncbi.nlm.nih.gov/pubmed/17218314 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 8522521 http://www.ncbi.nlm.nih.gov/pubmed/8522521 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418330 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418330 SMART SM00926 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00926 STRING 511145.b3894 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3894&targetmode=cogs STRING COG0243 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0243&targetmode=cogs SUPFAM SSF50692 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50692 TIGRFAMs TIGR01553 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01553 UniProtKB FDOG_ECOLI http://www.uniprot.org/uniprot/FDOG_ECOLI UniProtKB-AC P32176 http://www.uniprot.org/uniprot/P32176 charge swissprot:FDOG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FDOG_ECOLI eggNOG COG0243 http://eggnogapi.embl.de/nog_data/html/tree/COG0243 eggNOG ENOG4107QIW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QIW epestfind swissprot:FDOG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FDOG_ECOLI garnier swissprot:FDOG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FDOG_ECOLI helixturnhelix swissprot:FDOG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FDOG_ECOLI hmoment swissprot:FDOG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FDOG_ECOLI iep swissprot:FDOG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FDOG_ECOLI inforesidue swissprot:FDOG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FDOG_ECOLI octanol swissprot:FDOG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FDOG_ECOLI pepcoil swissprot:FDOG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FDOG_ECOLI pepdigest swissprot:FDOG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FDOG_ECOLI pepinfo swissprot:FDOG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FDOG_ECOLI pepnet swissprot:FDOG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FDOG_ECOLI pepstats swissprot:FDOG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FDOG_ECOLI pepwheel swissprot:FDOG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FDOG_ECOLI pepwindow swissprot:FDOG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FDOG_ECOLI sigcleave swissprot:FDOG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FDOG_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES PSUK_ECOLI Kinetic parameters KM=120 uM for pseudouridine (in the presence of 0.5 mM ATP) {ECO 0000269|PubMed 18591240}; KM=330 uM for ATP (in the presence of 200 uM pseudouridine) {ECO 0000269|PubMed 18591240}; # BRENDA 2.7.1.83 2026 # BioGrid 4260461 17 # CATALYTIC ACTIVITY ATP + pseudouridine = ADP + pseudouridine 5'- phosphate. {ECO:0000269|PubMed 18591240}. # EcoGene EG11646 psuK # FUNCTION PSUK_ECOLI Catalyzes the phosphorylation of pseudouridine to pseudouridine 5'-phosphate (PsiMP). {ECO 0000269|PubMed 18591240}. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0050225 pseudouridine kinase activity; IDA:EcoliWiki. # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.1190.20 -; 1. # IntAct P30235 11 # InterPro IPR002173 Carboh/pur_kinase_PfkB_CS # InterPro IPR011611 PfkB_dom # InterPro IPR029056 Ribokinase-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00240 Pyrimidine metabolism # Organism PSUK_ECOLI Escherichia coli (strain K12) # PATRIC 32119681 VBIEscCol129921_2251 # PIR E64985 E64985 # PROSITE PS00583 PFKB_KINASES_1 # PROSITE PS00584 PFKB_KINASES_2 # Pfam PF00294 PfkB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PSUK_ECOLI Pseudouridine kinase # RefSeq NP_416671 NC_000913.3 # RefSeq WP_001208118 NZ_LN832404.1 # SIMILARITY Belongs to the carbohydrate kinase PfkB family. {ECO 0000305}. # SUPFAM SSF53613 SSF53613 # eggNOG COG0524 LUCA # eggNOG ENOG4105DD7 Bacteria BLAST swissprot:PSUK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PSUK_ECOLI BioCyc ECOL316407:JW2153-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2153-MONOMER BioCyc EcoCyc:EG11646-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11646-MONOMER COG COG0524 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0524 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M804122200 http://dx.doi.org/10.1074/jbc.M804122200 DOI 10.1099/00221287-134-10-2757 http://dx.doi.org/10.1099/00221287-134-10-2757 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.83 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.83 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M23196 http://www.ebi.ac.uk/ena/data/view/M23196 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.83 http://enzyme.expasy.org/EC/2.7.1.83 EchoBASE EB1599 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1599 EcoGene EG11646 http://www.ecogene.org/geneInfo.php?eg_id=EG11646 EnsemblBacteria AAC75227 http://www.ensemblgenomes.org/id/AAC75227 EnsemblBacteria AAC75227 http://www.ensemblgenomes.org/id/AAC75227 EnsemblBacteria BAE76643 http://www.ensemblgenomes.org/id/BAE76643 EnsemblBacteria BAE76643 http://www.ensemblgenomes.org/id/BAE76643 EnsemblBacteria BAE76643 http://www.ensemblgenomes.org/id/BAE76643 EnsemblBacteria b2166 http://www.ensemblgenomes.org/id/b2166 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0050225 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050225 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.1190.20 http://www.cathdb.info/version/latest/superfamily/3.40.1190.20 GeneID 946664 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946664 HOGENOM HOG000064422 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000064422&db=HOGENOM6 InParanoid P30235 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30235 IntAct P30235 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P30235* IntEnz 2.7.1.83 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.83 InterPro IPR002173 http://www.ebi.ac.uk/interpro/entry/IPR002173 InterPro IPR011611 http://www.ebi.ac.uk/interpro/entry/IPR011611 InterPro IPR029056 http://www.ebi.ac.uk/interpro/entry/IPR029056 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2153 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2153 KEGG_Gene eco:b2166 http://www.genome.jp/dbget-bin/www_bget?eco:b2166 KEGG_Orthology KO:K16328 http://www.genome.jp/dbget-bin/www_bget?KO:K16328 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Reaction rn:R03315 http://www.genome.jp/dbget-bin/www_bget?rn:R03315 OMA FAQGCSA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FAQGCSA PROSITE PS00583 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00583 PROSITE PS00584 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00584 PSORT swissprot:PSUK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PSUK_ECOLI PSORT-B swissprot:PSUK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PSUK_ECOLI PSORT2 swissprot:PSUK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PSUK_ECOLI Pfam PF00294 http://pfam.xfam.org/family/PF00294 Phobius swissprot:PSUK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PSUK_ECOLI PhylomeDB P30235 http://phylomedb.org/?seqid=P30235 ProteinModelPortal P30235 http://www.proteinmodelportal.org/query/uniprot/P30235 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18591240 http://www.ncbi.nlm.nih.gov/pubmed/18591240 PubMed 3076173 http://www.ncbi.nlm.nih.gov/pubmed/3076173 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416671 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416671 RefSeq WP_001208118 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001208118 SMR P30235 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P30235 STRING 511145.b2166 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2166&targetmode=cogs STRING COG0524 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0524&targetmode=cogs SUPFAM SSF53613 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53613 UniProtKB PSUK_ECOLI http://www.uniprot.org/uniprot/PSUK_ECOLI UniProtKB-AC P30235 http://www.uniprot.org/uniprot/P30235 charge swissprot:PSUK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PSUK_ECOLI eggNOG COG0524 http://eggnogapi.embl.de/nog_data/html/tree/COG0524 eggNOG ENOG4105DD7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DD7 epestfind swissprot:PSUK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PSUK_ECOLI garnier swissprot:PSUK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PSUK_ECOLI helixturnhelix swissprot:PSUK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PSUK_ECOLI hmoment swissprot:PSUK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PSUK_ECOLI iep swissprot:PSUK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PSUK_ECOLI inforesidue swissprot:PSUK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PSUK_ECOLI octanol swissprot:PSUK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PSUK_ECOLI pepcoil swissprot:PSUK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PSUK_ECOLI pepdigest swissprot:PSUK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PSUK_ECOLI pepinfo swissprot:PSUK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PSUK_ECOLI pepnet swissprot:PSUK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PSUK_ECOLI pepstats swissprot:PSUK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PSUK_ECOLI pepwheel swissprot:PSUK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PSUK_ECOLI pepwindow swissprot:PSUK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PSUK_ECOLI sigcleave swissprot:PSUK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PSUK_ECOLI ## Database ID URL or Descriptions # DISRUPTION PHENOTYPE No visible phenotype. {ECO:0000269|PubMed 8083180}. # EcoGene EG11250 chpS # FUNCTION CHPS_ECOLI Antitoxin component of a type II toxin-antitoxin (TA) module. May be involved in the regulation of cell growth. It acts as a suppressor of the endoribonuclease (inhibitory function) of ChpB protein. Both ChpS and ChpB probably bind to the promoter region of the chpS-chpB operon to autoregulate their synthesis. {ECO 0000269|PubMed 16413033, ECO 0000269|PubMed 8226627}. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0030307 positive regulation of cell growth; IMP:EcoCyc. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # INDUCTION Part of the chpS-chpB operon. {ECO:0000269|PubMed 8226627}. # InterPro IPR007159 SpoVT-AbrB_dom # Organism CHPS_ECOLI Escherichia coli (strain K12) # PATRIC 32124023 VBIEscCol129921_4356 # PIR S56450 QQECR8 # PROSITE PS51740 SPOVT_ABRB # Pfam PF04014 MazE_antitoxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CHPS_ECOLI Antitoxin ChpS # RefSeq NP_418645 NC_000913.3 # RefSeq WP_001223208 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA24011.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAA97121.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the PemI family. {ECO 0000305}. # SIMILARITY Contains 1 SpoVT-AbrB domain. {ECO:0000255|PROSITE- ProRule PRU01076}. # SMART SM00966 SpoVT_AbrB # SUBUNIT Interacts with ChpB, inhibiting its endoribonuclease activity. {ECO:0000269|PubMed 16413033}. # eggNOG ENOG41087RY Bacteria # eggNOG ENOG41102J6 LUCA BLAST swissprot:CHPS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CHPS_ECOLI BioCyc ECOL316407:JW5750-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5750-MONOMER BioCyc EcoCyc:EG11250-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11250-MONOMER BioCyc MetaCyc:EG11250-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11250-MONOMER DIP DIP-9280N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9280N DOI 10.1016/j.jmb.2005.12.033 http://dx.doi.org/10.1016/j.jmb.2005.12.033 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D16451 http://www.ebi.ac.uk/ena/data/view/D16451 EMBL M14018 http://www.ebi.ac.uk/ena/data/view/M14018 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB1230 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1230 EcoGene EG11250 http://www.ecogene.org/geneInfo.php?eg_id=EG11250 EnsemblBacteria AAC77181 http://www.ensemblgenomes.org/id/AAC77181 EnsemblBacteria AAC77181 http://www.ensemblgenomes.org/id/AAC77181 EnsemblBacteria BAE78225 http://www.ensemblgenomes.org/id/BAE78225 EnsemblBacteria BAE78225 http://www.ensemblgenomes.org/id/BAE78225 EnsemblBacteria BAE78225 http://www.ensemblgenomes.org/id/BAE78225 EnsemblBacteria b4224 http://www.ensemblgenomes.org/id/b4224 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0030307 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030307 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 948739 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948739 HOGENOM HOG000289070 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000289070&db=HOGENOM6 IntAct P08365 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P08365* InterPro IPR007159 http://www.ebi.ac.uk/interpro/entry/IPR007159 KEGG_Gene ecj:JW5750 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5750 KEGG_Gene eco:b4224 http://www.genome.jp/dbget-bin/www_bget?eco:b4224 MINT MINT-1263242 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1263242 OMA LEQMHAS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LEQMHAS PROSITE PS51740 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51740 PSORT swissprot:CHPS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CHPS_ECOLI PSORT-B swissprot:CHPS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CHPS_ECOLI PSORT2 swissprot:CHPS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CHPS_ECOLI Pfam PF04014 http://pfam.xfam.org/family/PF04014 Phobius swissprot:CHPS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CHPS_ECOLI PhylomeDB P08365 http://phylomedb.org/?seqid=P08365 ProteinModelPortal P08365 http://www.proteinmodelportal.org/query/uniprot/P08365 PubMed 16413033 http://www.ncbi.nlm.nih.gov/pubmed/16413033 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3525538 http://www.ncbi.nlm.nih.gov/pubmed/3525538 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8083180 http://www.ncbi.nlm.nih.gov/pubmed/8083180 PubMed 8226627 http://www.ncbi.nlm.nih.gov/pubmed/8226627 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418645 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418645 RefSeq WP_001223208 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001223208 SMART SM00966 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00966 SMR P08365 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P08365 STRING 511145.b4224 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4224&targetmode=cogs UniProtKB CHPS_ECOLI http://www.uniprot.org/uniprot/CHPS_ECOLI UniProtKB-AC P08365 http://www.uniprot.org/uniprot/P08365 charge swissprot:CHPS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CHPS_ECOLI eggNOG ENOG41087RY http://eggnogapi.embl.de/nog_data/html/tree/ENOG41087RY eggNOG ENOG41102J6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41102J6 epestfind swissprot:CHPS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CHPS_ECOLI garnier swissprot:CHPS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CHPS_ECOLI helixturnhelix swissprot:CHPS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CHPS_ECOLI hmoment swissprot:CHPS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CHPS_ECOLI iep swissprot:CHPS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CHPS_ECOLI inforesidue swissprot:CHPS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CHPS_ECOLI octanol swissprot:CHPS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CHPS_ECOLI pepcoil swissprot:CHPS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CHPS_ECOLI pepdigest swissprot:CHPS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CHPS_ECOLI pepinfo swissprot:CHPS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CHPS_ECOLI pepnet swissprot:CHPS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CHPS_ECOLI pepstats swissprot:CHPS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CHPS_ECOLI pepwheel swissprot:CHPS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CHPS_ECOLI pepwindow swissprot:CHPS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CHPS_ECOLI sigcleave swissprot:CHPS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CHPS_ECOLI ## Database ID URL or Descriptions # BioGrid 4259261 7 # EcoGene EG12751 yhaL # Organism YHAL_ECOLI Escherichia coli (strain K12) # PATRIC 32121634 VBIEscCol129921_3203 # PIR H65099 H65099 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHAL_ECOLI Uncharacterized protein YhaL # RefSeq NP_417578 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA57911.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # eggNOG ENOG4106D80 Bacteria # eggNOG ENOG410Y53A LUCA BLAST swissprot:YHAL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHAL_ECOLI BioCyc ECOL316407:JW5517-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5517-MONOMER BioCyc EcoCyc:G7621-MONOMER http://biocyc.org/getid?id=EcoCyc:G7621-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2607 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2607 EcoGene EG12751 http://www.ecogene.org/geneInfo.php?eg_id=EG12751 EnsemblBacteria AAC76142 http://www.ensemblgenomes.org/id/AAC76142 EnsemblBacteria AAC76142 http://www.ensemblgenomes.org/id/AAC76142 EnsemblBacteria BAE77157 http://www.ensemblgenomes.org/id/BAE77157 EnsemblBacteria BAE77157 http://www.ensemblgenomes.org/id/BAE77157 EnsemblBacteria BAE77157 http://www.ensemblgenomes.org/id/BAE77157 EnsemblBacteria b3107 http://www.ensemblgenomes.org/id/b3107 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947618 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947618 HOGENOM HOG000009593 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009593&db=HOGENOM6 KEGG_Gene ecj:JW5517 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5517 KEGG_Gene eco:b3107 http://www.genome.jp/dbget-bin/www_bget?eco:b3107 OMA RTANNFG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RTANNFG PSORT swissprot:YHAL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHAL_ECOLI PSORT-B swissprot:YHAL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHAL_ECOLI PSORT2 swissprot:YHAL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHAL_ECOLI Phobius swissprot:YHAL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHAL_ECOLI ProteinModelPortal P42625 http://www.proteinmodelportal.org/query/uniprot/P42625 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417578 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417578 SMR P42625 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P42625 STRING 511145.b3107 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3107&targetmode=cogs UniProtKB YHAL_ECOLI http://www.uniprot.org/uniprot/YHAL_ECOLI UniProtKB-AC P42625 http://www.uniprot.org/uniprot/P42625 charge swissprot:YHAL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHAL_ECOLI eggNOG ENOG4106D80 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106D80 eggNOG ENOG410Y53A http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y53A epestfind swissprot:YHAL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHAL_ECOLI garnier swissprot:YHAL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHAL_ECOLI helixturnhelix swissprot:YHAL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHAL_ECOLI hmoment swissprot:YHAL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHAL_ECOLI iep swissprot:YHAL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHAL_ECOLI inforesidue swissprot:YHAL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHAL_ECOLI octanol swissprot:YHAL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHAL_ECOLI pepcoil swissprot:YHAL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHAL_ECOLI pepdigest swissprot:YHAL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHAL_ECOLI pepinfo swissprot:YHAL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHAL_ECOLI pepnet swissprot:YHAL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHAL_ECOLI pepstats swissprot:YHAL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHAL_ECOLI pepwheel swissprot:YHAL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHAL_ECOLI pepwindow swissprot:YHAL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHAL_ECOLI sigcleave swissprot:YHAL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHAL_ECOLI ## Database ID URL or Descriptions # AltName F16PA_ECOLI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=1.7 uM for fructose 1,6-biphosphate {ECO 0000269|PubMed:16670087}; # BRENDA 3.1.3.11 2026 # BioGrid 4259316 10 # CATALYTIC ACTIVITY F16PA_ECOLI D-fructose 1,6-bisphosphate + H(2)O = D- fructose 6-phosphate + phosphate. # CDD cd00354 FBPase # COFACTOR F16PA_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 16670087, ECO 0000269|PubMed 17567577}; Note=Binds 2 magnesium ions per subunit. {ECO 0000269|PubMed 16670087, ECO 0000269|PubMed 17567577}; # ENZYME REGULATION F16PA_ECOLI Subject to complex allosteric regulation. The enzyme can assume an active R-state, or an inactive T-state. Intermediate conformations may exist. Activated by three-carbon carboxylic acids, phosphorylated three-carbon carboxylic acids and sulfate. Strongly activated by phosphoenolpyruvate and citrate. Inhibited by AMP, which affects the turnover of bound substrate and not the affinity for substrate. Allosterically inhibited by glucose 6-phosphate. AMP and glucose 6-phosphate act synergistically as allosteric inhibitors. Phosphoenolpyruvate antagonizes inhibition by AMP and glucose 6-phosphate. Fructose 2,6-bisphosphate acts as competitive inhibitor. {ECO 0000269|PubMed 16670087, ECO 0000269|PubMed 17314096, ECO 0000269|PubMed 17567577, ECO 0000269|PubMed 17933867}. # EcoGene EG10283 fbp # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000166 nucleotide binding; IEA:UniProtKB-KW. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity; IDA:EcoCyc. # GO_process GO:0005986 sucrose biosynthetic process; IBA:GO_Central. # GO_process GO:0006000 fructose metabolic process; IBA:GO_Central. # GO_process GO:0006001 fructose catabolic process; IEA:InterPro. # GO_process GO:0006002 fructose 6-phosphate metabolic process; IBA:GO_Central. # GO_process GO:0006094 gluconeogenesis; IMP:EcoCyc. # GO_process GO:0030388 fructose 1,6-bisphosphate metabolic process; IBA:GO_Central. # GO_process GO:0051289 protein homotetramerization; IPI:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # HAMAP MF_01855 FBPase_class1 # InterPro IPR000146 FBPase_class-1 # InterPro IPR020548 Fructose_bisphosphatase_AS # InterPro IPR028343 FBPtase # InterPro IPR033391 FBPase_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00010 Glycolysis / Gluconeogenesis # KEGG_Pathway ko00030 Pentose phosphate pathway # KEGG_Pathway ko00051 Fructose and mannose metabolism # KEGG_Pathway ko00680 Methane metabolism # KEGG_Pathway ko00710 Carbon fixation in photosynthetic organisms # KEGG_Pathway ko04910 Insulin signaling pathway # Organism F16PA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11556 PTHR11556 # PATHWAY F16PA_ECOLI Carbohydrate biosynthesis; gluconeogenesis. # PATRIC 32124037 VBIEscCol129921_4363 # PDB 2GQ1 X-ray; 1.45 A; A=1-332 # PDB 2OWZ X-ray; 2.18 A; A=1-332 # PDB 2OX3 X-ray; 2.18 A; A=1-332 # PDB 2Q8M X-ray; 2.05 A; A/B=1-332 # PDB 2QVR X-ray; 2.18 A; A=1-332 # PIR S01383 PAEC # PIRSF PIRSF000904 FBPtase_SBPase # PIRSF PIRSF500210 FBPtase # PRINTS PR00115 F16BPHPHTASE # PROSITE PS00124 FBPASE # Pfam PF00316 FBPase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName F16PA_ECOLI Fructose-1,6-bisphosphatase class 1 # RefSeq NP_418653 NC_000913.3 # RefSeq WP_000853753 NZ_LN832404.1 # SIMILARITY Belongs to the FBPase class 1 family. {ECO 0000305}. # SUBCELLULAR LOCATION F16PA_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT F16PA_ECOLI Homotetramer. Phosphoenolpyruvate stabilizes the homotetramer. {ECO 0000269|PubMed 16670087, ECO 0000269|PubMed 17314096, ECO 0000269|PubMed 17567577, ECO 0000269|PubMed 17933867}. # eggNOG COG0158 LUCA # eggNOG ENOG4105CZI Bacteria BLAST swissprot:F16PA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:F16PA_ECOLI BioCyc ECOL316407:JW4191-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4191-MONOMER BioCyc EcoCyc:F16B-MONOMER http://biocyc.org/getid?id=EcoCyc:F16B-MONOMER BioCyc MetaCyc:F16B-MONOMER http://biocyc.org/getid?id=MetaCyc:F16B-MONOMER COG COG0158 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0158 DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0006-291X(86)90005-7 http://dx.doi.org/10.1016/0006-291X(86)90005-7 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M602553200 http://dx.doi.org/10.1074/jbc.M602553200 DOI 10.1074/jbc.M611104200 http://dx.doi.org/10.1074/jbc.M611104200 DOI 10.1074/jbc.M703580200 http://dx.doi.org/10.1074/jbc.M703580200 DOI 10.1074/jbc.M707302200 http://dx.doi.org/10.1074/jbc.M707302200 DOI 10.1093/nar/16.17.8707 http://dx.doi.org/10.1093/nar/16.17.8707 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.3.11 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.11 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X12545 http://www.ebi.ac.uk/ena/data/view/X12545 ENZYME 3.1.3.11 http://enzyme.expasy.org/EC/3.1.3.11 EchoBASE EB0279 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0279 EcoGene EG10283 http://www.ecogene.org/geneInfo.php?eg_id=EG10283 EnsemblBacteria AAC77189 http://www.ensemblgenomes.org/id/AAC77189 EnsemblBacteria AAC77189 http://www.ensemblgenomes.org/id/AAC77189 EnsemblBacteria BAE78232 http://www.ensemblgenomes.org/id/BAE78232 EnsemblBacteria BAE78232 http://www.ensemblgenomes.org/id/BAE78232 EnsemblBacteria BAE78232 http://www.ensemblgenomes.org/id/BAE78232 EnsemblBacteria b4232 http://www.ensemblgenomes.org/id/b4232 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000166 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000166 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0042132 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042132 GO_process GO:0005986 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005986 GO_process GO:0006000 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006000 GO_process GO:0006001 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006001 GO_process GO:0006002 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006002 GO_process GO:0006094 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006094 GO_process GO:0030388 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030388 GO_process GO:0051289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051289 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 948753 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948753 HAMAP MF_01855 http://hamap.expasy.org/unirule/MF_01855 HOGENOM HOG000191265 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000191265&db=HOGENOM6 InParanoid P0A993 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A993 IntEnz 3.1.3.11 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.11 InterPro IPR000146 http://www.ebi.ac.uk/interpro/entry/IPR000146 InterPro IPR020548 http://www.ebi.ac.uk/interpro/entry/IPR020548 InterPro IPR028343 http://www.ebi.ac.uk/interpro/entry/IPR028343 InterPro IPR033391 http://www.ebi.ac.uk/interpro/entry/IPR033391 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4191 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4191 KEGG_Gene eco:b4232 http://www.genome.jp/dbget-bin/www_bget?eco:b4232 KEGG_Orthology KO:K03841 http://www.genome.jp/dbget-bin/www_bget?KO:K03841 KEGG_Pathway ko00010 http://www.genome.jp/kegg-bin/show_pathway?ko00010 KEGG_Pathway ko00030 http://www.genome.jp/kegg-bin/show_pathway?ko00030 KEGG_Pathway ko00051 http://www.genome.jp/kegg-bin/show_pathway?ko00051 KEGG_Pathway ko00680 http://www.genome.jp/kegg-bin/show_pathway?ko00680 KEGG_Pathway ko00710 http://www.genome.jp/kegg-bin/show_pathway?ko00710 KEGG_Pathway ko04910 http://www.genome.jp/kegg-bin/show_pathway?ko04910 KEGG_Reaction rn:R00762 http://www.genome.jp/dbget-bin/www_bget?rn:R00762 KEGG_Reaction rn:R04780 http://www.genome.jp/dbget-bin/www_bget?rn:R04780 OMA YTTRYIG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YTTRYIG PANTHER PTHR11556 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11556 PDB 2GQ1 http://www.ebi.ac.uk/pdbe-srv/view/entry/2GQ1 PDB 2OWZ http://www.ebi.ac.uk/pdbe-srv/view/entry/2OWZ PDB 2OX3 http://www.ebi.ac.uk/pdbe-srv/view/entry/2OX3 PDB 2Q8M http://www.ebi.ac.uk/pdbe-srv/view/entry/2Q8M PDB 2QVR http://www.ebi.ac.uk/pdbe-srv/view/entry/2QVR PDBsum 2GQ1 http://www.ebi.ac.uk/pdbsum/2GQ1 PDBsum 2OWZ http://www.ebi.ac.uk/pdbsum/2OWZ PDBsum 2OX3 http://www.ebi.ac.uk/pdbsum/2OX3 PDBsum 2Q8M http://www.ebi.ac.uk/pdbsum/2Q8M PDBsum 2QVR http://www.ebi.ac.uk/pdbsum/2QVR PRINTS PR00115 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00115 PROSITE PS00124 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00124 PSORT swissprot:F16PA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:F16PA_ECOLI PSORT-B swissprot:F16PA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:F16PA_ECOLI PSORT2 swissprot:F16PA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:F16PA_ECOLI Pfam PF00316 http://pfam.xfam.org/family/PF00316 Phobius swissprot:F16PA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:F16PA_ECOLI PhylomeDB P0A993 http://phylomedb.org/?seqid=P0A993 ProteinModelPortal P0A993 http://www.proteinmodelportal.org/query/uniprot/P0A993 PubMed 16670087 http://www.ncbi.nlm.nih.gov/pubmed/16670087 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17314096 http://www.ncbi.nlm.nih.gov/pubmed/17314096 PubMed 17567577 http://www.ncbi.nlm.nih.gov/pubmed/17567577 PubMed 17933867 http://www.ncbi.nlm.nih.gov/pubmed/17933867 PubMed 2843822 http://www.ncbi.nlm.nih.gov/pubmed/2843822 PubMed 3008716 http://www.ncbi.nlm.nih.gov/pubmed/3008716 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_418653 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418653 RefSeq WP_000853753 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000853753 SMR P0A993 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A993 STRING 511145.b4232 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4232&targetmode=cogs STRING COG0158 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0158&targetmode=cogs SWISS-2DPAGE P0A993 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A993 UniProtKB F16PA_ECOLI http://www.uniprot.org/uniprot/F16PA_ECOLI UniProtKB-AC P0A993 http://www.uniprot.org/uniprot/P0A993 charge swissprot:F16PA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:F16PA_ECOLI eggNOG COG0158 http://eggnogapi.embl.de/nog_data/html/tree/COG0158 eggNOG ENOG4105CZI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CZI epestfind swissprot:F16PA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:F16PA_ECOLI garnier swissprot:F16PA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:F16PA_ECOLI helixturnhelix swissprot:F16PA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:F16PA_ECOLI hmoment swissprot:F16PA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:F16PA_ECOLI iep swissprot:F16PA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:F16PA_ECOLI inforesidue swissprot:F16PA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:F16PA_ECOLI octanol swissprot:F16PA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:F16PA_ECOLI pepcoil swissprot:F16PA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:F16PA_ECOLI pepdigest swissprot:F16PA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:F16PA_ECOLI pepinfo swissprot:F16PA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:F16PA_ECOLI pepnet swissprot:F16PA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:F16PA_ECOLI pepstats swissprot:F16PA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:F16PA_ECOLI pepwheel swissprot:F16PA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:F16PA_ECOLI pepwindow swissprot:F16PA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:F16PA_ECOLI sigcleave swissprot:F16PA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:F16PA_ECOLI ## Database ID URL or Descriptions # AltName RFAG_ECOLI Glucosyltransferase I # BRENDA 2.4.1.B64 2026 # BioGrid 4260869 274 # CAZy GT4 Glycosyltransferase Family 4 # EcoGene EG11339 rfaG # FUNCTION RFAG_ECOLI Involved in the addition of the first glucose residue to the lipopolysaccharide core. # GO_function GO:0008919 lipopolysaccharide glucosyltransferase I activity; IDA:EcoCyc. # GO_process GO:0009244 lipopolysaccharide core region biosynthetic process; IMP:EcoCyc. # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # IntAct P25740 10 # InterPro IPR001296 Glyco_trans_1 # InterPro IPR028098 Glyco_trans_4-like_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01003 Glycosyltransferases # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # KEGG_Pathway ko00540 Lipopolysaccharide biosynthesis # Organism RFAG_ECOLI Escherichia coli (strain K12) # PATHWAY RFAG_ECOLI Bacterial outer membrane biogenesis; LPS core biosynthesis. # PATRIC 32122749 VBIEscCol129921_3751 # PDB 2IV7 X-ray; 1.60 A; A=1-374 # PDB 2IW1 X-ray; 1.50 A; A=1-374 # PDB 2N58 NMR; -; A=103-132 # PIR B42595 B42595 # Pfam PF00534 Glycos_transf_1 # Pfam PF13439 Glyco_transf_4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RFAG_ECOLI Lipopolysaccharide core biosynthesis protein RfaG # RefSeq NP_418088 NC_000913.3 # RefSeq WP_000634283 NZ_LN832404.1 # SIMILARITY Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. {ECO 0000305}. # eggNOG ENOG4107RJ7 Bacteria # eggNOG ENOG410XPWS LUCA BLAST swissprot:RFAG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RFAG_ECOLI BioCyc ECOL316407:JW3606-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3606-MONOMER BioCyc EcoCyc:EG11339-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11339-MONOMER BioCyc MetaCyc:EG11339-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11339-MONOMER COG CAZy: http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=CAZy: COG COG0438 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0438 COG GT4 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=GT4 DOI 10.1016/0378-1097(94)90295-X http://dx.doi.org/10.1016/0378-1097(94)90295-X DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.4.-.- http://www.genome.jp/dbget-bin/www_bget?EC:2.4.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M80599 http://www.ebi.ac.uk/ena/data/view/M80599 EMBL M86305 http://www.ebi.ac.uk/ena/data/view/M86305 EMBL S75736 http://www.ebi.ac.uk/ena/data/view/S75736 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.4.-.- http://enzyme.expasy.org/EC/2.4.-.- EchoBASE EB1315 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1315 EcoGene EG11339 http://www.ecogene.org/geneInfo.php?eg_id=EG11339 EnsemblBacteria AAC76655 http://www.ensemblgenomes.org/id/AAC76655 EnsemblBacteria AAC76655 http://www.ensemblgenomes.org/id/AAC76655 EnsemblBacteria BAE77661 http://www.ensemblgenomes.org/id/BAE77661 EnsemblBacteria BAE77661 http://www.ensemblgenomes.org/id/BAE77661 EnsemblBacteria BAE77661 http://www.ensemblgenomes.org/id/BAE77661 EnsemblBacteria b3631 http://www.ensemblgenomes.org/id/b3631 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008919 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008919 GO_process GO:0009244 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009244 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 948149 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948149 HOGENOM HOG000126226 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126226&db=HOGENOM6 InParanoid P25740 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P25740 IntAct P25740 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P25740* IntEnz 2.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4 InterPro IPR001296 http://www.ebi.ac.uk/interpro/entry/IPR001296 InterPro IPR028098 http://www.ebi.ac.uk/interpro/entry/IPR028098 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01003 http://www.genome.jp/dbget-bin/www_bget?ko01003 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Gene ecj:JW3606 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3606 KEGG_Gene eco:b3631 http://www.genome.jp/dbget-bin/www_bget?eco:b3631 KEGG_Orthology KO:K02844 http://www.genome.jp/dbget-bin/www_bget?KO:K02844 KEGG_Pathway ko00540 http://www.genome.jp/kegg-bin/show_pathway?ko00540 OMA IHICNPR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IHICNPR PDB 2IV7 http://www.ebi.ac.uk/pdbe-srv/view/entry/2IV7 PDB 2IW1 http://www.ebi.ac.uk/pdbe-srv/view/entry/2IW1 PDB 2N58 http://www.ebi.ac.uk/pdbe-srv/view/entry/2N58 PDBsum 2IV7 http://www.ebi.ac.uk/pdbsum/2IV7 PDBsum 2IW1 http://www.ebi.ac.uk/pdbsum/2IW1 PDBsum 2N58 http://www.ebi.ac.uk/pdbsum/2N58 PSORT swissprot:RFAG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RFAG_ECOLI PSORT-B swissprot:RFAG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RFAG_ECOLI PSORT2 swissprot:RFAG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RFAG_ECOLI Pfam PF00534 http://pfam.xfam.org/family/PF00534 Pfam PF13439 http://pfam.xfam.org/family/PF13439 Phobius swissprot:RFAG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RFAG_ECOLI PhylomeDB P25740 http://phylomedb.org/?seqid=P25740 ProteinModelPortal P25740 http://www.proteinmodelportal.org/query/uniprot/P25740 PubMed 1447141 http://www.ncbi.nlm.nih.gov/pubmed/1447141 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1732225 http://www.ncbi.nlm.nih.gov/pubmed/1732225 PubMed 7988890 http://www.ncbi.nlm.nih.gov/pubmed/7988890 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418088 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418088 RefSeq WP_000634283 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000634283 SMR P25740 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P25740 STRING 511145.b3631 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3631&targetmode=cogs STRING CAZy: http://string-db.org/newstring_cgi/show_network_section.pl?identifier=CAZy:&targetmode=cogs STRING COG0438 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0438&targetmode=cogs STRING GT4 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=GT4&targetmode=cogs UniProtKB RFAG_ECOLI http://www.uniprot.org/uniprot/RFAG_ECOLI UniProtKB-AC P25740 http://www.uniprot.org/uniprot/P25740 charge swissprot:RFAG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RFAG_ECOLI eggNOG ENOG4107RJ7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107RJ7 eggNOG ENOG410XPWS http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPWS epestfind swissprot:RFAG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RFAG_ECOLI garnier swissprot:RFAG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RFAG_ECOLI helixturnhelix swissprot:RFAG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RFAG_ECOLI hmoment swissprot:RFAG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RFAG_ECOLI iep swissprot:RFAG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RFAG_ECOLI inforesidue swissprot:RFAG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RFAG_ECOLI octanol swissprot:RFAG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RFAG_ECOLI pepcoil swissprot:RFAG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RFAG_ECOLI pepdigest swissprot:RFAG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RFAG_ECOLI pepinfo swissprot:RFAG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RFAG_ECOLI pepnet swissprot:RFAG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RFAG_ECOLI pepstats swissprot:RFAG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RFAG_ECOLI pepwheel swissprot:RFAG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RFAG_ECOLI pepwindow swissprot:RFAG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RFAG_ECOLI sigcleave swissprot:RFAG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RFAG_ECOLI ## Database ID URL or Descriptions # BRENDA 3.1.1.61 2026 # BioGrid 4260716 220 # CATALYTIC ACTIVITY CHEB_ECOLI Protein L-glutamate O(5)-methyl ester + H(2)O = protein L-glutamate + methanol. # DOMAIN CHEB_ECOLI The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain. # EcoGene EG10147 cheB # FUNCTION CHEB_ECOLI Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_function GO:0000156 phosphorelay response regulator activity; IEA:InterPro. # GO_function GO:0008984 protein-glutamate methylesterase activity; IEA:UniProtKB-HAMAP. # GO_process GO:0006935 chemotaxis; IMP:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0004871 signal transducer activity # GOslim_process GO:0040011 locomotion # Gene3D 3.40.50.180 -; 1. # HAMAP MF_00099 CheB_methylest # IntAct P07330 10 # InterPro IPR000673 Sig_transdc_resp-reg_Me-estase # InterPro IPR001789 Sig_transdc_resp-reg_receiver # InterPro IPR008248 Sig_transdc_resp-reg_CheB # InterPro IPR011006 CheY-like_superfamily # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02022 M00506 CheA-CheYBV (chemotaxis) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Brite ko02030 M00506 CheA-CheYBV (chemotaxis) two-component regulatory system # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Brite ko02035 M00506 CheA-CheYBV (chemotaxis) two-component regulatory system # KEGG_Pathway ko02020 Two-component system # KEGG_Pathway ko02030 Bacterial chemotaxis # Organism CHEB_ECOLI Escherichia coli (strain K12) # PATRIC 32119093 VBIEscCol129921_1964 # PIR D25195 XYECEB # PIRSF PIRSF000876 RR_chemtxs_CheB # PROSITE PS50110 RESPONSE_REGULATORY # PROSITE PS50122 CHEB # PTM CHEB_ECOLI Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain. {ECO 0000269|PubMed 3280143}. # Pfam PF00072 Response_reg # Pfam PF01339 CheB_methylest # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CHEB_ECOLI Chemotaxis response regulator protein-glutamate methylesterase # RefSeq NP_416397 NC_000913.3 # RefSeq WP_000036361 NZ_LN832404.1 # SIMILARITY Contains 1 cheB-type methylesterase domain. {ECO 0000305}. # SIMILARITY Contains 1 response regulatory domain. {ECO:0000255|PROSITE-ProRule PRU00169, ECO:0000305}. # SMART SM00448 REC # SUBCELLULAR LOCATION CHEB_ECOLI Cytoplasm. # SUPFAM SSF52172 SSF52172 # SUPFAM SSF52738 SSF52738 # eggNOG COG2201 LUCA # eggNOG ENOG4105CMP Bacteria BLAST swissprot:CHEB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CHEB_ECOLI BioCyc ECOL316407:JW1872-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1872-MONOMER BioCyc EcoCyc:CHEB-MONOMER http://biocyc.org/getid?id=EcoCyc:CHEB-MONOMER BioCyc MetaCyc:CHEB-MONOMER http://biocyc.org/getid?id=MetaCyc:CHEB-MONOMER COG COG2201 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2201 DIP DIP-9272N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9272N DOI 10.1016/0092-8674(88)90489-8 http://dx.doi.org/10.1016/0092-8674(88)90489-8 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.1.61 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.1.61 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M13463 http://www.ebi.ac.uk/ena/data/view/M13463 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.1.61 http://enzyme.expasy.org/EC/3.1.1.61 EchoBASE EB0145 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0145 EcoGene EG10147 http://www.ecogene.org/geneInfo.php?eg_id=EG10147 EnsemblBacteria AAC74953 http://www.ensemblgenomes.org/id/AAC74953 EnsemblBacteria AAC74953 http://www.ensemblgenomes.org/id/AAC74953 EnsemblBacteria BAA15699 http://www.ensemblgenomes.org/id/BAA15699 EnsemblBacteria BAA15699 http://www.ensemblgenomes.org/id/BAA15699 EnsemblBacteria BAA15699 http://www.ensemblgenomes.org/id/BAA15699 EnsemblBacteria b1883 http://www.ensemblgenomes.org/id/b1883 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0000156 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000156 GO_function GO:0008984 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008984 GO_process GO:0006935 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006935 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_process GO:0040011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011 Gene3D 3.40.50.180 http://www.cathdb.info/version/latest/superfamily/3.40.50.180 GeneID 946394 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946394 HAMAP MF_00099 http://hamap.expasy.org/unirule/MF_00099 HOGENOM HOG000151423 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000151423&db=HOGENOM6 InParanoid P07330 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P07330 IntAct P07330 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P07330* IntEnz 3.1.1.61 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.1.61 InterPro IPR000673 http://www.ebi.ac.uk/interpro/entry/IPR000673 InterPro IPR001789 http://www.ebi.ac.uk/interpro/entry/IPR001789 InterPro IPR008248 http://www.ebi.ac.uk/interpro/entry/IPR008248 InterPro IPR011006 http://www.ebi.ac.uk/interpro/entry/IPR011006 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02030 http://www.genome.jp/dbget-bin/www_bget?ko02030 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW1872 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1872 KEGG_Gene eco:b1883 http://www.genome.jp/dbget-bin/www_bget?eco:b1883 KEGG_Orthology KO:K03412 http://www.genome.jp/dbget-bin/www_bget?KO:K03412 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 KEGG_Pathway ko02030 http://www.genome.jp/kegg-bin/show_pathway?ko02030 OMA MLEMHRA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MLEMHRA PROSITE PS50110 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50110 PROSITE PS50122 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50122 PSORT swissprot:CHEB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CHEB_ECOLI PSORT-B swissprot:CHEB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CHEB_ECOLI PSORT2 swissprot:CHEB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CHEB_ECOLI Pfam PF00072 http://pfam.xfam.org/family/PF00072 Pfam PF01339 http://pfam.xfam.org/family/PF01339 Phobius swissprot:CHEB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CHEB_ECOLI PhylomeDB P07330 http://phylomedb.org/?seqid=P07330 ProteinModelPortal P07330 http://www.proteinmodelportal.org/query/uniprot/P07330 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3280143 http://www.ncbi.nlm.nih.gov/pubmed/3280143 PubMed 3510184 http://www.ncbi.nlm.nih.gov/pubmed/3510184 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416397 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416397 RefSeq WP_000036361 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000036361 SMART SM00448 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00448 SMR P07330 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P07330 STRING 511145.b1883 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1883&targetmode=cogs STRING COG2201 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2201&targetmode=cogs SUPFAM SSF52172 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52172 SUPFAM SSF52738 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52738 UniProtKB CHEB_ECOLI http://www.uniprot.org/uniprot/CHEB_ECOLI UniProtKB-AC P07330 http://www.uniprot.org/uniprot/P07330 charge swissprot:CHEB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CHEB_ECOLI eggNOG COG2201 http://eggnogapi.embl.de/nog_data/html/tree/COG2201 eggNOG ENOG4105CMP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CMP epestfind swissprot:CHEB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CHEB_ECOLI garnier swissprot:CHEB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CHEB_ECOLI helixturnhelix swissprot:CHEB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CHEB_ECOLI hmoment swissprot:CHEB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CHEB_ECOLI iep swissprot:CHEB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CHEB_ECOLI inforesidue swissprot:CHEB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CHEB_ECOLI octanol swissprot:CHEB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CHEB_ECOLI pepcoil swissprot:CHEB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CHEB_ECOLI pepdigest swissprot:CHEB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CHEB_ECOLI pepinfo swissprot:CHEB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CHEB_ECOLI pepnet swissprot:CHEB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CHEB_ECOLI pepstats swissprot:CHEB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CHEB_ECOLI pepwheel swissprot:CHEB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CHEB_ECOLI pepwindow swissprot:CHEB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CHEB_ECOLI sigcleave swissprot:CHEB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CHEB_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES PSUG_ECOLI Kinetic parameters KM=60 uM for pseudouridine 5'-phosphate (in the presence of 0.5 mM Mn(2+)) {ECO 0000269|PubMed 18591240}; KM=169.6 uM for uracil {ECO 0000269|PubMed 23066817}; Note=kcat is 3.74 sec(-1) for the synthesis of PsiMP. {ECO 0000269|PubMed 23066817}; # BRENDA 4.2.1.70 2026 # BioGrid 4261702 6 # CATALYTIC ACTIVITY PSUG_ECOLI Uracil + D-ribose 5-phosphate = pseudouridine 5'-phosphate + H(2)O. {ECO 0000255|HAMAP-Rule MF_01876, ECO 0000269|PubMed 18591240, ECO 0000269|PubMed 23066817}. # COFACTOR PSUG_ECOLI Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000255|HAMAP-Rule MF_01876, ECO 0000269|PubMed 18591240, ECO 0000269|PubMed 23066817}; Name=Fe(2+); Xref=ChEBI CHEBI 29033; Evidence={ECO 0000269|PubMed 18591240, ECO 0000269|PubMed 23066817}; Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000269|PubMed 18591240, ECO 0000269|PubMed 23066817}; Note=Binds 1 manganese ion per subunit. Can also use Fe(2+) and Co(2+). The unusual metal binding site is heavily hydrated, coordinated with an aspartate side chain and five water molecules, and likely plays a role in anchoring the PsiMP phosphate. {ECO 0000269|PubMed 18591240, ECO 0000269|PubMed 23066817}; # ENZYME REGULATION Inhibited by Zn(2+) and Ni(2+). {ECO:0000269|PubMed 18591240}. # EcoGene EG12033 psuG # FUNCTION PSUG_ECOLI Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway. {ECO 0000255|HAMAP-Rule MF_01876, ECO 0000269|PubMed 18591240, ECO 0000269|PubMed 23066817}. # GO_function GO:0004730 pseudouridylate synthase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0016798 hydrolase activity, acting on glycosyl bonds; IDA:EcoliWiki. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0046113 nucleobase catabolic process; IEA:UniProtKB-HAMAP. # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # HAMAP MF_01876 PsiMP_glycosidase # IntAct P33025 13 # InterPro IPR007342 PsuG # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00240 Pyrimidine metabolism # Organism PSUG_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10584:SF1 PTHR10584:SF1 # PATRIC 32119679 VBIEscCol129921_2250 # PDB 4GIJ X-ray; 1.94 A; A/B/C=1-312 # PDB 4GIK X-ray; 2.19 A; A/B/C=1-312 # PDB 4GIL X-ray; 2.54 A; A/B/C=1-312 # PDB 4GIM X-ray; 1.80 A; A/B/C=1-312 # PIR D64985 D64985 # Pfam PF04227 Indigoidine_A # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PSUG_ECOLI Pseudouridine-5'-phosphate glycosidase {ECO 0000255|HAMAP-Rule MF_01876, ECO 0000303|PubMed 18591240} # RefSeq NP_416670 NC_000913.3 # RefSeq WP_001292460 NZ_LN832404.1 # SIMILARITY Belongs to the pseudouridine-5'-phosphate glycosidase family. {ECO:0000255|HAMAP-Rule MF_01876}. # SUBUNIT PSUG_ECOLI Homotrimer. {ECO 0000255|HAMAP-Rule MF_01876, ECO 0000269|PubMed 23066817}. # eggNOG COG2313 LUCA # eggNOG ENOG4105D53 Bacteria BLAST swissprot:PSUG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PSUG_ECOLI BioCyc ECOL316407:JW2152-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2152-MONOMER BioCyc EcoCyc:EG12033-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12033-MONOMER COG COG2313 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2313 DIP DIP-11926N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11926N DOI 10.1021/bi3006829 http://dx.doi.org/10.1021/bi3006829 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M804122200 http://dx.doi.org/10.1074/jbc.M804122200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.1.70 {ECO:0000255|HAMAP-Rule:MF_01876, ECO:0000269|PubMed:18591240, ECO:0000269|PubMed:23066817} http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.70 {ECO:0000255|HAMAP-Rule:MF_01876, ECO:0000269|PubMed:18591240, ECO:0000269|PubMed:23066817} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 4.2.1.70 {ECO:0000255|HAMAP-Rule:MF_01876, ECO:0000269|PubMed:18591240, ECO:0000269|PubMed:23066817} http://enzyme.expasy.org/EC/4.2.1.70 {ECO:0000255|HAMAP-Rule:MF_01876, ECO:0000269|PubMed:18591240, ECO:0000269|PubMed:23066817} EchoBASE EB1968 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1968 EcoGene EG12033 http://www.ecogene.org/geneInfo.php?eg_id=EG12033 EnsemblBacteria AAC75226 http://www.ensemblgenomes.org/id/AAC75226 EnsemblBacteria AAC75226 http://www.ensemblgenomes.org/id/AAC75226 EnsemblBacteria BAE76642 http://www.ensemblgenomes.org/id/BAE76642 EnsemblBacteria BAE76642 http://www.ensemblgenomes.org/id/BAE76642 EnsemblBacteria BAE76642 http://www.ensemblgenomes.org/id/BAE76642 EnsemblBacteria b2165 http://www.ensemblgenomes.org/id/b2165 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004730 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004730 GO_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0046113 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046113 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 946699 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946699 HAMAP MF_01876 http://hamap.expasy.org/unirule/MF_01876 HOGENOM HOG000064311 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000064311&db=HOGENOM6 InParanoid P33025 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33025 IntAct P33025 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33025* IntEnz 4.2.1.70 {ECO:0000255|HAMAP-Rule:MF_01876, ECO:0000269|PubMed:18591240, ECO:0000269|PubMed:23066817} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.70 {ECO:0000255|HAMAP-Rule:MF_01876, ECO:0000269|PubMed:18591240, ECO:0000269|PubMed:23066817} InterPro IPR007342 http://www.ebi.ac.uk/interpro/entry/IPR007342 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2152 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2152 KEGG_Gene eco:b2165 http://www.genome.jp/dbget-bin/www_bget?eco:b2165 KEGG_Orthology KO:K16329 http://www.genome.jp/dbget-bin/www_bget?KO:K16329 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Reaction rn:R01055 http://www.genome.jp/dbget-bin/www_bget?rn:R01055 MINT MINT-1308217 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1308217 OMA IIAHGMP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IIAHGMP PANTHER PTHR10584:SF1 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10584:SF1 PDB 4GIJ http://www.ebi.ac.uk/pdbe-srv/view/entry/4GIJ PDB 4GIK http://www.ebi.ac.uk/pdbe-srv/view/entry/4GIK PDB 4GIL http://www.ebi.ac.uk/pdbe-srv/view/entry/4GIL PDB 4GIM http://www.ebi.ac.uk/pdbe-srv/view/entry/4GIM PDBsum 4GIJ http://www.ebi.ac.uk/pdbsum/4GIJ PDBsum 4GIK http://www.ebi.ac.uk/pdbsum/4GIK PDBsum 4GIL http://www.ebi.ac.uk/pdbsum/4GIL PDBsum 4GIM http://www.ebi.ac.uk/pdbsum/4GIM PSORT swissprot:PSUG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PSUG_ECOLI PSORT-B swissprot:PSUG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PSUG_ECOLI PSORT2 swissprot:PSUG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PSUG_ECOLI Pfam PF04227 http://pfam.xfam.org/family/PF04227 Phobius swissprot:PSUG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PSUG_ECOLI PhylomeDB P33025 http://phylomedb.org/?seqid=P33025 ProteinModelPortal P33025 http://www.proteinmodelportal.org/query/uniprot/P33025 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18591240 http://www.ncbi.nlm.nih.gov/pubmed/18591240 PubMed 23066817 http://www.ncbi.nlm.nih.gov/pubmed/23066817 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416670 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416670 RefSeq WP_001292460 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001292460 SMR P33025 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33025 STRING 511145.b2165 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2165&targetmode=cogs STRING COG2313 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2313&targetmode=cogs UniProtKB PSUG_ECOLI http://www.uniprot.org/uniprot/PSUG_ECOLI UniProtKB-AC P33025 http://www.uniprot.org/uniprot/P33025 charge swissprot:PSUG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PSUG_ECOLI eggNOG COG2313 http://eggnogapi.embl.de/nog_data/html/tree/COG2313 eggNOG ENOG4105D53 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D53 epestfind swissprot:PSUG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PSUG_ECOLI garnier swissprot:PSUG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PSUG_ECOLI helixturnhelix swissprot:PSUG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PSUG_ECOLI hmoment swissprot:PSUG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PSUG_ECOLI iep swissprot:PSUG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PSUG_ECOLI inforesidue swissprot:PSUG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PSUG_ECOLI octanol swissprot:PSUG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PSUG_ECOLI pepcoil swissprot:PSUG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PSUG_ECOLI pepdigest swissprot:PSUG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PSUG_ECOLI pepinfo swissprot:PSUG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PSUG_ECOLI pepnet swissprot:PSUG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PSUG_ECOLI pepstats swissprot:PSUG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PSUG_ECOLI pepwheel swissprot:PSUG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PSUG_ECOLI pepwindow swissprot:PSUG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PSUG_ECOLI sigcleave swissprot:PSUG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PSUG_ECOLI ## Database ID URL or Descriptions # AltName PTRB_ECOLI Oligopeptidase B # AltName PTRB_ECOLI Protease II # BRENDA 3.4.21.83 2026 # BioGrid 4263144 14 # CATALYTIC ACTIVITY PTRB_ECOLI Hydrolysis of -Arg-|-Xaa- and -Lys-|-Xaa- bonds in oligopeptides, even when P1' residue is proline. # ESTHER ecoli-ptrb S9N_PREPL_Peptidase_S9 # EcoGene EG11004 ptrB # FUNCTION PTRB_ECOLI Cleaves peptide bonds on the C-terminal side of lysyl and argininyl residues. # GO_component GO:0005737 cytoplasm; IDA:EcoCyc. # GO_function GO:0004252 serine-type endopeptidase activity; IDA:EcoCyc. # GO_function GO:0070008 serine-type exopeptidase activity; IEA:InterPro. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0008233 peptidase activity # Gene3D 2.130.10.120 -; 1. # Gene3D 3.40.50.1820 -; 1. # IntAct P24555 3 # InterPro IPR001375 Peptidase_S9 # InterPro IPR002470 Peptidase_S9A # InterPro IPR002471 Pept_S9_AS # InterPro IPR023302 Pept_S9A_N # InterPro IPR029058 AB_hydrolase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # KEGG_Pathway ko05142 Chagas disease (American trypanosomiasis) # KEGG_Pathway ko05143 African trypanosomiasis # Organism PTRB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11757 PTHR11757 # PATRIC 32119011 VBIEscCol129921_1923 # PIR E64946 E64946 # PRINTS PR00862 PROLIGOPTASE # PROSITE PS00708 PRO_ENDOPEP_SER # Pfam PF00326 Peptidase_S9 # Pfam PF02897 Peptidase_S9_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PTRB_ECOLI Protease 2 # RefSeq NP_416359 NC_000913.3 # RefSeq WP_000936927 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase S9A family. {ECO 0000305}. # SUPFAM SSF53474 SSF53474 # eggNOG COG1770 LUCA # eggNOG ENOG4105CUG Bacteria BLAST swissprot:PTRB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTRB_ECOLI BioCyc ECOL316407:JW1834-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1834-MONOMER BioCyc EcoCyc:EG11004-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11004-MONOMER BioCyc MetaCyc:EG11004-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11004-MONOMER COG COG1770 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1770 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.21.83 http://www.genome.jp/dbget-bin/www_bget?EC:3.4.21.83 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D10976 http://www.ebi.ac.uk/ena/data/view/D10976 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.4.21.83 http://enzyme.expasy.org/EC/3.4.21.83 EchoBASE EB0997 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0997 EcoGene EG11004 http://www.ecogene.org/geneInfo.php?eg_id=EG11004 EnsemblBacteria AAC74915 http://www.ensemblgenomes.org/id/AAC74915 EnsemblBacteria AAC74915 http://www.ensemblgenomes.org/id/AAC74915 EnsemblBacteria BAA15651 http://www.ensemblgenomes.org/id/BAA15651 EnsemblBacteria BAA15651 http://www.ensemblgenomes.org/id/BAA15651 EnsemblBacteria BAA15651 http://www.ensemblgenomes.org/id/BAA15651 EnsemblBacteria b1845 http://www.ensemblgenomes.org/id/b1845 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004252 GO_function GO:0070008 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070008 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 Gene3D 2.130.10.120 http://www.cathdb.info/version/latest/superfamily/2.130.10.120 Gene3D 3.40.50.1820 http://www.cathdb.info/version/latest/superfamily/3.40.50.1820 GeneID 946358 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946358 HOGENOM HOG000249811 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000249811&db=HOGENOM6 InParanoid P24555 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P24555 IntAct P24555 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P24555* IntEnz 3.4.21.83 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.21.83 InterPro IPR001375 http://www.ebi.ac.uk/interpro/entry/IPR001375 InterPro IPR002470 http://www.ebi.ac.uk/interpro/entry/IPR002470 InterPro IPR002471 http://www.ebi.ac.uk/interpro/entry/IPR002471 InterPro IPR023302 http://www.ebi.ac.uk/interpro/entry/IPR023302 InterPro IPR029058 http://www.ebi.ac.uk/interpro/entry/IPR029058 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW1834 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1834 KEGG_Gene eco:b1845 http://www.genome.jp/dbget-bin/www_bget?eco:b1845 KEGG_Orthology KO:K01354 http://www.genome.jp/dbget-bin/www_bget?KO:K01354 KEGG_Pathway ko05142 http://www.genome.jp/kegg-bin/show_pathway?ko05142 KEGG_Pathway ko05143 http://www.genome.jp/kegg-bin/show_pathway?ko05143 OMA SLDPWFS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SLDPWFS PANTHER PTHR11757 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11757 PRINTS PR00862 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00862 PROSITE PS00708 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00708 PSORT swissprot:PTRB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTRB_ECOLI PSORT-B swissprot:PTRB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTRB_ECOLI PSORT2 swissprot:PTRB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTRB_ECOLI Pfam PF00326 http://pfam.xfam.org/family/PF00326 Pfam PF02897 http://pfam.xfam.org/family/PF02897 Phobius swissprot:PTRB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTRB_ECOLI PhylomeDB P24555 http://phylomedb.org/?seqid=P24555 ProteinModelPortal P24555 http://www.proteinmodelportal.org/query/uniprot/P24555 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1769955 http://www.ncbi.nlm.nih.gov/pubmed/1769955 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416359 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416359 RefSeq WP_000936927 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000936927 SMR P24555 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P24555 STRING 511145.b1845 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1845&targetmode=cogs STRING COG1770 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1770&targetmode=cogs SUPFAM SSF53474 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53474 UniProtKB PTRB_ECOLI http://www.uniprot.org/uniprot/PTRB_ECOLI UniProtKB-AC P24555 http://www.uniprot.org/uniprot/P24555 charge swissprot:PTRB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTRB_ECOLI eggNOG COG1770 http://eggnogapi.embl.de/nog_data/html/tree/COG1770 eggNOG ENOG4105CUG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CUG epestfind swissprot:PTRB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTRB_ECOLI garnier swissprot:PTRB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTRB_ECOLI helixturnhelix swissprot:PTRB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTRB_ECOLI hmoment swissprot:PTRB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTRB_ECOLI iep swissprot:PTRB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTRB_ECOLI inforesidue swissprot:PTRB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTRB_ECOLI octanol swissprot:PTRB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTRB_ECOLI pepcoil swissprot:PTRB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTRB_ECOLI pepdigest swissprot:PTRB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTRB_ECOLI pepinfo swissprot:PTRB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTRB_ECOLI pepnet swissprot:PTRB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTRB_ECOLI pepstats swissprot:PTRB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTRB_ECOLI pepwheel swissprot:PTRB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTRB_ECOLI pepwindow swissprot:PTRB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTRB_ECOLI sigcleave swissprot:PTRB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTRB_ECOLI ## Database ID URL or Descriptions # BioGrid 4263120 168 # EcoGene EG13711 elfC # FUNCTION ELFC_ECOLI Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be involved in the export and assembly of the ElfA fimbrial subunits across the outer membrane. {ECO 0000269|PubMed 20345943}. # GO_component GO:0009279 cell outer membrane; IBA:GO_Central. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015473 fimbrial usher porin activity; IBA:GO_Central. # GO_process GO:0009297 pilus assembly; IBA:GO_Central. # GO_process GO:0043711 pilus organization; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0022607 cellular component assembly # INDUCTION Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression. {ECO:0000269|PubMed 20345943}. # InterPro IPR000015 Fimb_usher # InterPro IPR018030 Fimbrial_membr_usher_CS # InterPro IPR025885 PapC_N # InterPro IPR025949 PapC-like_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02000 Transporters # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko05133 Pertussis # MISCELLANEOUS The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed. {ECO:0000305|PubMed 20345943}. # Organism ELFC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30451 PTHR30451 # PATRIC 32117099 VBIEscCol129921_0974 # PIR C64834 C64834 # PROSITE PS01151 FIMBRIAL_USHER # Pfam PF00577 Usher # Pfam PF13953 PapC_C # Pfam PF13954 PapC_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ELFC_ECOLI Probable outer membrane usher protein ElfC # RefSeq NP_415460 NC_000913.3 # RefSeq WP_000286312 NZ_LN832404.1 # SIMILARITY Belongs to the fimbrial export usher family. {ECO 0000305}. # SUBCELLULAR LOCATION ELFC_ECOLI Cell outer membrane {ECO 0000250}; Multi- pass membrane protein {ECO 0000250}. # eggNOG COG3188 LUCA # eggNOG ENOG4105CW0 Bacteria BLAST swissprot:ELFC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ELFC_ECOLI BioCyc ECOL316407:JW0923-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0923-MONOMER BioCyc EcoCyc:G6482-MONOMER http://biocyc.org/getid?id=EcoCyc:G6482-MONOMER COG COG3188 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3188 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1462-2920.2010.02202.x http://dx.doi.org/10.1111/j.1462-2920.2010.02202.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3475 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3475 EcoGene EG13711 http://www.ecogene.org/geneInfo.php?eg_id=EG13711 EnsemblBacteria AAC74026 http://www.ensemblgenomes.org/id/AAC74026 EnsemblBacteria AAC74026 http://www.ensemblgenomes.org/id/AAC74026 EnsemblBacteria BAA35695 http://www.ensemblgenomes.org/id/BAA35695 EnsemblBacteria BAA35695 http://www.ensemblgenomes.org/id/BAA35695 EnsemblBacteria BAA35695 http://www.ensemblgenomes.org/id/BAA35695 EnsemblBacteria b0940 http://www.ensemblgenomes.org/id/b0940 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015473 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015473 GO_process GO:0009297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009297 GO_process GO:0043711 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043711 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GeneID 946934 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946934 HOGENOM HOG000111414 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000111414&db=HOGENOM6 InParanoid P75857 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75857 InterPro IPR000015 http://www.ebi.ac.uk/interpro/entry/IPR000015 InterPro IPR018030 http://www.ebi.ac.uk/interpro/entry/IPR018030 InterPro IPR025885 http://www.ebi.ac.uk/interpro/entry/IPR025885 InterPro IPR025949 http://www.ebi.ac.uk/interpro/entry/IPR025949 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW0923 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0923 KEGG_Gene eco:b0940 http://www.genome.jp/dbget-bin/www_bget?eco:b0940 KEGG_Orthology KO:K07347 http://www.genome.jp/dbget-bin/www_bget?KO:K07347 KEGG_Pathway ko05133 http://www.genome.jp/kegg-bin/show_pathway?ko05133 OMA ICHISYE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ICHISYE PANTHER PTHR30451 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30451 PROSITE PS01151 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01151 PSORT swissprot:ELFC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ELFC_ECOLI PSORT-B swissprot:ELFC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ELFC_ECOLI PSORT2 swissprot:ELFC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ELFC_ECOLI Pfam PF00577 http://pfam.xfam.org/family/PF00577 Pfam PF13953 http://pfam.xfam.org/family/PF13953 Pfam PF13954 http://pfam.xfam.org/family/PF13954 Phobius swissprot:ELFC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ELFC_ECOLI PhylomeDB P75857 http://phylomedb.org/?seqid=P75857 ProteinModelPortal P75857 http://www.proteinmodelportal.org/query/uniprot/P75857 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20345943 http://www.ncbi.nlm.nih.gov/pubmed/20345943 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415460 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415460 RefSeq WP_000286312 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000286312 SMR P75857 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75857 STRING 511145.b0940 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0940&targetmode=cogs STRING COG3188 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3188&targetmode=cogs UniProtKB ELFC_ECOLI http://www.uniprot.org/uniprot/ELFC_ECOLI UniProtKB-AC P75857 http://www.uniprot.org/uniprot/P75857 charge swissprot:ELFC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ELFC_ECOLI eggNOG COG3188 http://eggnogapi.embl.de/nog_data/html/tree/COG3188 eggNOG ENOG4105CW0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CW0 epestfind swissprot:ELFC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ELFC_ECOLI garnier swissprot:ELFC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ELFC_ECOLI helixturnhelix swissprot:ELFC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ELFC_ECOLI hmoment swissprot:ELFC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ELFC_ECOLI iep swissprot:ELFC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ELFC_ECOLI inforesidue swissprot:ELFC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ELFC_ECOLI octanol swissprot:ELFC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ELFC_ECOLI pepcoil swissprot:ELFC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ELFC_ECOLI pepdigest swissprot:ELFC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ELFC_ECOLI pepinfo swissprot:ELFC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ELFC_ECOLI pepnet swissprot:ELFC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ELFC_ECOLI pepstats swissprot:ELFC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ELFC_ECOLI pepwheel swissprot:ELFC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ELFC_ECOLI pepwindow swissprot:ELFC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ELFC_ECOLI sigcleave swissprot:ELFC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ELFC_ECOLI ## Database ID URL or Descriptions # BioGrid 4261865 8 # CATALYTIC ACTIVITY DUSB_ECOLI 5,6-dihydrouracil in tRNA + NAD(P)(+) = uracil in tRNA + NAD(P)H. {ECO 0000250|UniProtKB P33371, ECO 0000255|HAMAP-Rule MF_02042}. # COFACTOR DUSB_ECOLI Name=FMN; Xref=ChEBI CHEBI 58210; Evidence={ECO 0000250|UniProtKB P33371, ECO 0000255|HAMAP-Rule MF_02042}; # DISRUPTION PHENOTYPE A dusA dusB dusC triple mutant exhibits a complete lack of 5,6-dihydrouridine modification in cellular tRNA, whereas each single mutant exhibits a partial reduction, compared to wild type. {ECO:0000269|PubMed 11983710}. # EcoGene EG11311 dusB # FUNCTION DUSB_ECOLI Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. {ECO 0000255|HAMAP- Rule MF_02042, ECO 0000269|PubMed 11983710}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0000049 tRNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0010181 FMN binding; IEA:UniProtKB-HAMAP. # GO_function GO:0017150 tRNA dihydrouridine synthase activity; IMP:EcoCyc. # GO_function GO:0050660 flavin adenine dinucleotide binding; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # Gene3D 1.10.1200.80 -; 1. # Gene3D 3.20.20.70 -; 1. # HAMAP MF_02042 DusB_subfam # IntAct P0ABT5 4 # InterPro IPR001269 tRNA_hU_synthase # InterPro IPR004652 tRNA_dU_NifR3 # InterPro IPR013785 Aldolase_TIM # InterPro IPR018517 tRNA_hU_synthase_CS # InterPro IPR024036 tRNA-dHydroUridine_Synthase_C # InterPro IPR032887 DusB # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # MISCELLANEOUS DusB and DusC together account for about half of the 5,6-dihydrouridine modification observed in wild-type cellular tRNA, and DusA accounts for the other half. These three enzymes seem to act site-specifically on the tRNA D-loop and contain nonredundant catalytic functions in vivo. {ECO:0000269|PubMed 11983710}. # Organism DUSB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11082 PTHR11082 # PATRIC 32121950 VBIEscCol129921_3359 # PIR B47043 B47043 # PIRSF PIRSF006621 Dus # PROSITE PS01136 UPF0034 # Pfam PF01207 Dus # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DUSB_ECOLI tRNA-dihydrouridine synthase B {ECO 0000255|HAMAP-Rule MF_02042, ECO 0000303|PubMed 11983710} # RefSeq NP_417726 NC_000913.3 # RefSeq WP_001219652 NZ_LN832404.1 # SIMILARITY Belongs to the Dus family. DusB subfamily. {ECO:0000255|HAMAP-Rule MF_02042, ECO:0000305}. # TIGRFAMs TIGR00737 nifR3_yhdG # eggNOG COG0042 LUCA # eggNOG ENOG4105CEH Bacteria BLAST swissprot:DUSB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DUSB_ECOLI BioCyc ECOL316407:JW3228-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3228-MONOMER BioCyc EcoCyc:EG11311-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11311-MONOMER BioCyc MetaCyc:EG11311-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11311-MONOMER COG COG0042 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0042 DIP DIP-48240N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48240N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.85.10.3484 http://dx.doi.org/10.1073/pnas.85.10.3484 DOI 10.1073/pnas.85.12.4237 http://dx.doi.org/10.1073/pnas.85.12.4237 DOI 10.1074/jbc.M203208200 http://dx.doi.org/10.1074/jbc.M203208200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.3.1.- {ECO:0000255|HAMAP-Rule:MF_02042, ECO:0000305} http://www.genome.jp/dbget-bin/www_bget?EC:1.3.1.- {ECO:0000255|HAMAP-Rule:MF_02042, ECO:0000305} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J03245 http://www.ebi.ac.uk/ena/data/view/J03245 EMBL J03816 http://www.ebi.ac.uk/ena/data/view/J03816 EMBL M95784 http://www.ebi.ac.uk/ena/data/view/M95784 EMBL S67010 http://www.ebi.ac.uk/ena/data/view/S67010 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X62399 http://www.ebi.ac.uk/ena/data/view/X62399 ENZYME 1.3.1.- {ECO:0000255|HAMAP-Rule:MF_02042, ECO:0000305} http://enzyme.expasy.org/EC/1.3.1.- {ECO:0000255|HAMAP-Rule:MF_02042, ECO:0000305} EchoBASE EB1287 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1287 EcoGene EG11311 http://www.ecogene.org/geneInfo.php?eg_id=EG11311 EnsemblBacteria AAC76292 http://www.ensemblgenomes.org/id/AAC76292 EnsemblBacteria AAC76292 http://www.ensemblgenomes.org/id/AAC76292 EnsemblBacteria BAE77301 http://www.ensemblgenomes.org/id/BAE77301 EnsemblBacteria BAE77301 http://www.ensemblgenomes.org/id/BAE77301 EnsemblBacteria BAE77301 http://www.ensemblgenomes.org/id/BAE77301 EnsemblBacteria b3260 http://www.ensemblgenomes.org/id/b3260 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000049 GO_function GO:0010181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010181 GO_function GO:0017150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017150 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 1.10.1200.80 http://www.cathdb.info/version/latest/superfamily/1.10.1200.80 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 947707 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947707 HAMAP MF_02042 http://hamap.expasy.org/unirule/MF_02042 HOGENOM HOG000217855 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000217855&db=HOGENOM6 InParanoid P0ABT5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABT5 IntAct P0ABT5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABT5* IntEnz 1.3.1.- {ECO:0000255|HAMAP-Rule:MF_02042, ECO:0000305} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.3.1.- {ECO:0000255|HAMAP-Rule:MF_02042, ECO:0000305} InterPro IPR001269 http://www.ebi.ac.uk/interpro/entry/IPR001269 InterPro IPR004652 http://www.ebi.ac.uk/interpro/entry/IPR004652 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR018517 http://www.ebi.ac.uk/interpro/entry/IPR018517 InterPro IPR024036 http://www.ebi.ac.uk/interpro/entry/IPR024036 InterPro IPR032887 http://www.ebi.ac.uk/interpro/entry/IPR032887 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW3228 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3228 KEGG_Gene eco:b3260 http://www.genome.jp/dbget-bin/www_bget?eco:b3260 KEGG_Orthology KO:K05540 http://www.genome.jp/dbget-bin/www_bget?KO:K05540 OMA WLFREIE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WLFREIE PANTHER PTHR11082 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11082 PROSITE PS01136 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01136 PSORT swissprot:DUSB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DUSB_ECOLI PSORT-B swissprot:DUSB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DUSB_ECOLI PSORT2 swissprot:DUSB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DUSB_ECOLI Pfam PF01207 http://pfam.xfam.org/family/PF01207 Phobius swissprot:DUSB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DUSB_ECOLI PhylomeDB P0ABT5 http://phylomedb.org/?seqid=P0ABT5 ProteinModelPortal P0ABT5 http://www.proteinmodelportal.org/query/uniprot/P0ABT5 PubMed 11983710 http://www.ncbi.nlm.nih.gov/pubmed/11983710 PubMed 1459953 http://www.ncbi.nlm.nih.gov/pubmed/1459953 PubMed 1547773 http://www.ncbi.nlm.nih.gov/pubmed/1547773 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2835774 http://www.ncbi.nlm.nih.gov/pubmed/2835774 PubMed 2837762 http://www.ncbi.nlm.nih.gov/pubmed/2837762 PubMed 8226664 http://www.ncbi.nlm.nih.gov/pubmed/8226664 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417726 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417726 RefSeq WP_001219652 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001219652 SMR P0ABT5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABT5 STRING 511145.b3260 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3260&targetmode=cogs STRING COG0042 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0042&targetmode=cogs TIGRFAMs TIGR00737 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00737 UniProtKB DUSB_ECOLI http://www.uniprot.org/uniprot/DUSB_ECOLI UniProtKB-AC P0ABT5 http://www.uniprot.org/uniprot/P0ABT5 charge swissprot:DUSB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DUSB_ECOLI eggNOG COG0042 http://eggnogapi.embl.de/nog_data/html/tree/COG0042 eggNOG ENOG4105CEH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CEH epestfind swissprot:DUSB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DUSB_ECOLI garnier swissprot:DUSB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DUSB_ECOLI helixturnhelix swissprot:DUSB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DUSB_ECOLI hmoment swissprot:DUSB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DUSB_ECOLI iep swissprot:DUSB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DUSB_ECOLI inforesidue swissprot:DUSB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DUSB_ECOLI octanol swissprot:DUSB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DUSB_ECOLI pepcoil swissprot:DUSB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DUSB_ECOLI pepdigest swissprot:DUSB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DUSB_ECOLI pepinfo swissprot:DUSB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DUSB_ECOLI pepnet swissprot:DUSB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DUSB_ECOLI pepstats swissprot:DUSB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DUSB_ECOLI pepwheel swissprot:DUSB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DUSB_ECOLI pepwindow swissprot:DUSB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DUSB_ECOLI sigcleave swissprot:DUSB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DUSB_ECOLI ## Database ID URL or Descriptions # BRENDA 2.7.13 2026 # BioGrid 4263270 7 # CATALYTIC ACTIVITY NARX_ECOLI ATP + protein L-histidine = ADP + protein N- phospho-L-histidine. # CDD cd06225 HAMP # EcoGene EG10646 narX # FUNCTION NARX_ECOLI Acts as a sensor for nitrate/nitrite and transduces signal of nitrate availability to the NarL protein and of both nitrate/nitrite to the NarP protein. NarX probably activates NarL and NarP by phosphorylation in the presence of nitrate. NarX also plays a negative role in controlling NarL activity, probably through dephosphorylation in the absence of nitrate. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0000155 phosphorelay sensor kinase activity; IDA:EcoCyc. # GO_function GO:0004721 phosphoprotein phosphatase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0000160 phosphorelay signal transduction system; IDA:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0042128 nitrate assimilation; IEA:UniProtKB-KW. # GO_process GO:0046777 protein autophosphorylation; IDA:EcoCyc. # GO_process GO:0071249 cellular response to nitrate; IEP:EcoCyc. # GO_process GO:0071250 cellular response to nitrite; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005622 intracellular # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0071941 nitrogen cycle metabolic process # Gene3D 3.30.565.10 -; 1. # IntAct P0AFA2 4 # InterPro IPR003594 HATPase_C # InterPro IPR003660 HAMP_dom # InterPro IPR005467 His_kinase_dom # InterPro IPR011712 Sig_transdc_His_kin_sub3_dim/P # InterPro IPR016380 Sig_transdc_His_kin_NarX/NarQ # InterPro IPR029095 NarX-like_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01001 Protein kinases # KEGG_Brite ko02022 M00471 NarX-NarL (nitrate respiration) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # Organism NARX_ECOLI Escherichia coli (strain K12) # PATRIC 32117702 VBIEscCol129921_1273 # PDB 3EZH X-ray; 1.70 A; A/B=38-151 # PDB 3EZI X-ray; 1.70 A; A/B/C/D=42-148 # PIR S26137 RGECNX # PIRSF PIRSF003167 STHK_NarX/NarQ # PROSITE PS50109 HIS_KIN # PROSITE PS50885 HAMP # Pfam PF00672 HAMP # Pfam PF02518 HATPase_c # Pfam PF07730 HisKA_3 # Pfam PF13675 PilJ # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NARX_ECOLI Nitrate/nitrite sensor protein NarX # RefSeq NP_415740 NC_000913.3 # RefSeq WP_000918073 NZ_LN832404.1 # SIMILARITY Contains 1 HAMP domain. {ECO:0000255|PROSITE- ProRule PRU00102}. # SIMILARITY Contains 1 histidine kinase domain. {ECO:0000255|PROSITE-ProRule PRU00107}. # SMART SM00304 HAMP # SMART SM00387 HATPase_c # SUBCELLULAR LOCATION NARX_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # SUPFAM SSF55874 SSF55874 # eggNOG ENOG4105BZU Bacteria # eggNOG ENOG410XNMH LUCA BLAST swissprot:NARX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NARX_ECOLI BioCyc ECOL316407:JW1213-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1213-MONOMER BioCyc EcoCyc:NARX-MONOMER http://biocyc.org/getid?id=EcoCyc:NARX-MONOMER COG COG3850 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3850 DIP DIP-35785N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35785N DOI 10.1016/0014-5793(89)80906-8 http://dx.doi.org/10.1016/0014-5793(89)80906-8 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/17.8.2947 http://dx.doi.org/10.1093/nar/17.8.2947 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.13.3 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.13.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M24910 http://www.ebi.ac.uk/ena/data/view/M24910 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X13360 http://www.ebi.ac.uk/ena/data/view/X13360 EMBL X15996 http://www.ebi.ac.uk/ena/data/view/X15996 EMBL X65715 http://www.ebi.ac.uk/ena/data/view/X65715 EMBL X69189 http://www.ebi.ac.uk/ena/data/view/X69189 ENZYME 2.7.13.3 http://enzyme.expasy.org/EC/2.7.13.3 EchoBASE EB0640 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0640 EcoGene EG10646 http://www.ecogene.org/geneInfo.php?eg_id=EG10646 EnsemblBacteria AAC74306 http://www.ensemblgenomes.org/id/AAC74306 EnsemblBacteria AAC74306 http://www.ensemblgenomes.org/id/AAC74306 EnsemblBacteria BAA36090 http://www.ensemblgenomes.org/id/BAA36090 EnsemblBacteria BAA36090 http://www.ensemblgenomes.org/id/BAA36090 EnsemblBacteria BAA36090 http://www.ensemblgenomes.org/id/BAA36090 EnsemblBacteria b1222 http://www.ensemblgenomes.org/id/b1222 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0000155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000155 GO_function GO:0004721 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004721 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0042128 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042128 GO_process GO:0046777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046777 GO_process GO:0071249 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071249 GO_process GO:0071250 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071250 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0071941 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071941 Gene3D 3.30.565.10 http://www.cathdb.info/version/latest/superfamily/3.30.565.10 GeneID 945788 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945788 HOGENOM HOG000275465 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275465&db=HOGENOM6 InParanoid P0AFA2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFA2 IntAct P0AFA2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFA2* IntEnz 2.7.13.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.13.3 InterPro IPR003594 http://www.ebi.ac.uk/interpro/entry/IPR003594 InterPro IPR003660 http://www.ebi.ac.uk/interpro/entry/IPR003660 InterPro IPR005467 http://www.ebi.ac.uk/interpro/entry/IPR005467 InterPro IPR011712 http://www.ebi.ac.uk/interpro/entry/IPR011712 InterPro IPR016380 http://www.ebi.ac.uk/interpro/entry/IPR016380 InterPro IPR029095 http://www.ebi.ac.uk/interpro/entry/IPR029095 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01001 http://www.genome.jp/dbget-bin/www_bget?ko01001 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW1213 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1213 KEGG_Gene eco:b1222 http://www.genome.jp/dbget-bin/www_bget?eco:b1222 KEGG_Orthology KO:K07673 http://www.genome.jp/dbget-bin/www_bget?KO:K07673 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA AIDQKTE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AIDQKTE PDB 3EZH http://www.ebi.ac.uk/pdbe-srv/view/entry/3EZH PDB 3EZI http://www.ebi.ac.uk/pdbe-srv/view/entry/3EZI PDBsum 3EZH http://www.ebi.ac.uk/pdbsum/3EZH PDBsum 3EZI http://www.ebi.ac.uk/pdbsum/3EZI PROSITE PS50109 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50109 PROSITE PS50885 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50885 PSORT swissprot:NARX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NARX_ECOLI PSORT-B swissprot:NARX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NARX_ECOLI PSORT2 swissprot:NARX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NARX_ECOLI Pfam PF00672 http://pfam.xfam.org/family/PF00672 Pfam PF02518 http://pfam.xfam.org/family/PF02518 Pfam PF07730 http://pfam.xfam.org/family/PF07730 Pfam PF13675 http://pfam.xfam.org/family/PF13675 Phobius swissprot:NARX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NARX_ECOLI PhylomeDB P0AFA2 http://phylomedb.org/?seqid=P0AFA2 ProteinModelPortal P0AFA2 http://www.proteinmodelportal.org/query/uniprot/P0AFA2 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2649492 http://www.ncbi.nlm.nih.gov/pubmed/2649492 PubMed 2657652 http://www.ncbi.nlm.nih.gov/pubmed/2657652 PubMed 2668029 http://www.ncbi.nlm.nih.gov/pubmed/2668029 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415740 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415740 RefSeq WP_000918073 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000918073 SMART SM00304 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00304 SMART SM00387 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00387 SMR P0AFA2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFA2 STRING 511145.b1222 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1222&targetmode=cogs STRING COG3850 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3850&targetmode=cogs SUPFAM SSF55874 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55874 UniProtKB NARX_ECOLI http://www.uniprot.org/uniprot/NARX_ECOLI UniProtKB-AC P0AFA2 http://www.uniprot.org/uniprot/P0AFA2 charge swissprot:NARX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NARX_ECOLI eggNOG ENOG4105BZU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZU eggNOG ENOG410XNMH http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNMH epestfind swissprot:NARX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NARX_ECOLI garnier swissprot:NARX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NARX_ECOLI helixturnhelix swissprot:NARX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NARX_ECOLI hmoment swissprot:NARX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NARX_ECOLI iep swissprot:NARX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NARX_ECOLI inforesidue swissprot:NARX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NARX_ECOLI octanol swissprot:NARX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NARX_ECOLI pepcoil swissprot:NARX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NARX_ECOLI pepdigest swissprot:NARX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NARX_ECOLI pepinfo swissprot:NARX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NARX_ECOLI pepnet swissprot:NARX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NARX_ECOLI pepstats swissprot:NARX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NARX_ECOLI pepwheel swissprot:NARX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NARX_ECOLI pepwindow swissprot:NARX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NARX_ECOLI sigcleave swissprot:NARX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NARX_ECOLI ## Database ID URL or Descriptions # BioGrid 4261729 66 # EcoGene EG13936 rsxD # FUNCTION RSXD_ECOLI Part of a membrane complex involved in electron transport. Required to maintain the reduced state of SoxR. {ECO 0000255|HAMAP-Rule MF_00462, ECO 0000269|PubMed 12773378}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006810 transport; IEA:InterPro. # GO_process GO:0022900 electron transport chain; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0006810 transport # HAMAP MF_00462 RsxD_RnfD # InterPro IPR004338 NADH_Q_Rdtase_NQR2_RnfD # InterPro IPR011303 Elect_transpt_RnfD/RsxD # Organism RSXD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30578:SF0 PTHR30578:SF0 # PATRIC 32118562 VBIEscCol129921_1701 # PIR H64919 H64919 # Pfam PF03116 NQR2_RnfD_RnfE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Electron transport complex subunit RsxD {ECO:0000255|HAMAP-Rule MF_00462} # RefSeq NP_416147 NC_000913.3 # RefSeq WP_000231927 NZ_LN832404.1 # SIMILARITY Belongs to the NqrB/RnfD family. {ECO:0000255|HAMAP- Rule MF_00462}. # SUBCELLULAR LOCATION RSXD_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_00462}; Multi-pass membrane protein {ECO 0000255|HAMAP- Rule MF_00462}. # SUBUNIT Composed of six subunits; RsxA, RsxB, RsxC, RsxD, RsxE and RsxG. {ECO:0000305|PubMed 12773378}. # TCDB 3.D.6.1:the putative ion (h(+) or na(+))-translocating nadh ferredoxin oxidoreductase (nfo or rnf) family # TIGRFAMs TIGR01946 rnfD # eggNOG COG4658 LUCA # eggNOG ENOG4105D6A Bacteria BLAST swissprot:RSXD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RSXD_ECOLI BioCyc ECOL316407:JW1622-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1622-MONOMER BioCyc EcoCyc:G6874-MONOMER http://biocyc.org/getid?id=EcoCyc:G6874-MONOMER COG COG1805 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1805 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/emboj/cdg252 http://dx.doi.org/10.1093/emboj/cdg252 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3695 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3695 EcoGene EG13936 http://www.ecogene.org/geneInfo.php?eg_id=EG13936 EnsemblBacteria AAC74702 http://www.ensemblgenomes.org/id/AAC74702 EnsemblBacteria AAC74702 http://www.ensemblgenomes.org/id/AAC74702 EnsemblBacteria BAE76487 http://www.ensemblgenomes.org/id/BAE76487 EnsemblBacteria BAE76487 http://www.ensemblgenomes.org/id/BAE76487 EnsemblBacteria BAE76487 http://www.ensemblgenomes.org/id/BAE76487 EnsemblBacteria b1630 http://www.ensemblgenomes.org/id/b1630 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GO_process GO:0022900 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022900 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 946134 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946134 HAMAP MF_00462 http://hamap.expasy.org/unirule/MF_00462 HOGENOM HOG000273665 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000273665&db=HOGENOM6 InParanoid P76182 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76182 InterPro IPR004338 http://www.ebi.ac.uk/interpro/entry/IPR004338 InterPro IPR011303 http://www.ebi.ac.uk/interpro/entry/IPR011303 KEGG_Gene ecj:JW1622 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1622 KEGG_Gene eco:b1630 http://www.genome.jp/dbget-bin/www_bget?eco:b1630 KEGG_Orthology KO:K03614 http://www.genome.jp/dbget-bin/www_bget?KO:K03614 OMA YLIRTWG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YLIRTWG PANTHER PTHR30578:SF0 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30578:SF0 PSORT swissprot:RSXD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RSXD_ECOLI PSORT-B swissprot:RSXD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RSXD_ECOLI PSORT2 swissprot:RSXD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RSXD_ECOLI Pfam PF03116 http://pfam.xfam.org/family/PF03116 Phobius swissprot:RSXD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RSXD_ECOLI PhylomeDB P76182 http://phylomedb.org/?seqid=P76182 ProteinModelPortal P76182 http://www.proteinmodelportal.org/query/uniprot/P76182 PubMed 12773378 http://www.ncbi.nlm.nih.gov/pubmed/12773378 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416147 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416147 RefSeq WP_000231927 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000231927 STRING 511145.b1630 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1630&targetmode=cogs STRING COG1805 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1805&targetmode=cogs TCDB 3.D.6.1 http://www.tcdb.org/search/result.php?tc=3.D.6.1 TIGRFAMs TIGR01946 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01946 UniProtKB RSXD_ECOLI http://www.uniprot.org/uniprot/RSXD_ECOLI UniProtKB-AC P76182 http://www.uniprot.org/uniprot/P76182 charge swissprot:RSXD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RSXD_ECOLI eggNOG COG4658 http://eggnogapi.embl.de/nog_data/html/tree/COG4658 eggNOG ENOG4105D6A http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D6A epestfind swissprot:RSXD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RSXD_ECOLI garnier swissprot:RSXD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RSXD_ECOLI helixturnhelix swissprot:RSXD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RSXD_ECOLI hmoment swissprot:RSXD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RSXD_ECOLI iep swissprot:RSXD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RSXD_ECOLI inforesidue swissprot:RSXD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RSXD_ECOLI octanol swissprot:RSXD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RSXD_ECOLI pepcoil swissprot:RSXD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RSXD_ECOLI pepdigest swissprot:RSXD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RSXD_ECOLI pepinfo swissprot:RSXD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RSXD_ECOLI pepnet swissprot:RSXD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RSXD_ECOLI pepstats swissprot:RSXD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RSXD_ECOLI pepwheel swissprot:RSXD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RSXD_ECOLI pepwindow swissprot:RSXD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RSXD_ECOLI sigcleave swissprot:RSXD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RSXD_ECOLI ## Database ID URL or Descriptions # DISRUPTION PHENOTYPE TRBI_ECOLI Expresses approximately normal numbers of F pili that are unusually long, remains plasmid transfer proficient, displays increased resistance to F-pilus-specific phage (PubMed 1355084). Resistant to phage R17 and M13, conjugates at lower efficiency (about 10% of wild-type), resistant to CdiA-CT toxin (PubMed 24889811). {ECO 0000269|PubMed 1355084, ECO 0000269|PubMed 24889811}. # FUNCTION TRBI_ECOLI May influence the kinetics of pilus outgrowth and/or retraction (PubMed 1355084). Overexpression phenocopies the deletion mutation; i.e. causes resistance to F-pilus-specific phage and CdiA-CT toxin (PubMed 24889811). {ECO 0000269|PubMed 24889811, ECO 0000305|PubMed 1355084}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR014115 TrbI_Ftype # Organism TRBI_ECOLI Escherichia coli (strain K12) # PIR A42938 A42938 # Pfam PF09677 TrbI_Ftype # RecName TRBI_ECOLI Protein TrbI # RefSeq NP_061464 NC_002483.1 # SUBCELLULAR LOCATION TRBI_ECOLI Cell inner membrane {ECO 0000269|PubMed 1355084}; Single-pass membrane protein {ECO 0000305|PubMed 1355084}. # TIGRFAMs TIGR02744 TrbI_Ftype BLAST swissprot:TRBI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRBI_ECOLI DIP DIP-28101N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-28101N DOI 10.1016/0378-1119(90)90354-T http://dx.doi.org/10.1016/0378-1119(90)90354-T DOI 10.1111/mmi.12658 http://dx.doi.org/10.1111/mmi.12658 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL M30936 http://www.ebi.ac.uk/ena/data/view/M30936 EMBL M93106 http://www.ebi.ac.uk/ena/data/view/M93106 EMBL U01159 http://www.ebi.ac.uk/ena/data/view/U01159 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 1263557 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263557 InterPro IPR014115 http://www.ebi.ac.uk/interpro/entry/IPR014115 OMA AERRSHW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AERRSHW PSORT swissprot:TRBI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRBI_ECOLI PSORT-B swissprot:TRBI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRBI_ECOLI PSORT2 swissprot:TRBI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRBI_ECOLI Pfam PF09677 http://pfam.xfam.org/family/PF09677 Phobius swissprot:TRBI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRBI_ECOLI ProteinModelPortal P18006 http://www.proteinmodelportal.org/query/uniprot/P18006 PubMed 1355084 http://www.ncbi.nlm.nih.gov/pubmed/1355084 PubMed 2265751 http://www.ncbi.nlm.nih.gov/pubmed/2265751 PubMed 24889811 http://www.ncbi.nlm.nih.gov/pubmed/24889811 PubMed 7915817 http://www.ncbi.nlm.nih.gov/pubmed/7915817 RefSeq NP_061464 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061464 TIGRFAMs TIGR02744 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02744 UniProtKB TRBI_ECOLI http://www.uniprot.org/uniprot/TRBI_ECOLI UniProtKB-AC P18006 http://www.uniprot.org/uniprot/P18006 charge swissprot:TRBI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRBI_ECOLI epestfind swissprot:TRBI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRBI_ECOLI garnier swissprot:TRBI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRBI_ECOLI helixturnhelix swissprot:TRBI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRBI_ECOLI hmoment swissprot:TRBI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRBI_ECOLI iep swissprot:TRBI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRBI_ECOLI inforesidue swissprot:TRBI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRBI_ECOLI octanol swissprot:TRBI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRBI_ECOLI pepcoil swissprot:TRBI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRBI_ECOLI pepdigest swissprot:TRBI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRBI_ECOLI pepinfo swissprot:TRBI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRBI_ECOLI pepnet swissprot:TRBI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRBI_ECOLI pepstats swissprot:TRBI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRBI_ECOLI pepwheel swissprot:TRBI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRBI_ECOLI pepwindow swissprot:TRBI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRBI_ECOLI sigcleave swissprot:TRBI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRBI_ECOLI ## Database ID URL or Descriptions # BioGrid 4261621 106 # CATALYTIC ACTIVITY DPO2_ECOLI Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). # ENZYME REGULATION DPO2_ECOLI DNA polymerase II activity is regulated by the lexA gene during the SOS response. # EcoGene EG10747 polB # FUNCTION DPO2_ECOLI Thought to be involved in DNA repair and/or mutagenesis. # GO_function GO:0000166 nucleotide binding; IEA:InterPro. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003887 DNA-directed DNA polymerase activity; IDA:EcoCyc. # GO_function GO:0008296 3'-5'-exodeoxyribonuclease activity; IDA:EcoCyc. # GO_process GO:0006261 DNA-dependent DNA replication; IMP:EcoCyc. # GO_process GO:0009432 SOS response; IEP:EcoCyc. # GO_process GO:0045004 DNA replication proofreading; IDA:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004518 nuclease activity # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.30.420.10 -; 1. # Gene3D 3.90.1600.10 -; 2. # IntAct P21189 5 # InterPro IPR006133 DNA-dir_DNA_pol_B_exonuc # InterPro IPR006134 DNA-dir_DNA_pol_B_multi_dom # InterPro IPR006172 DNA-dir_DNA_pol_B # InterPro IPR012337 RNaseH-like_dom # InterPro IPR017964 DNA-dir_DNA_pol_B_CS # InterPro IPR023211 DNA_pol_palm_dom # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # Organism DPO2_ECOLI Escherichia coli (strain K12) # PATRIC 32115221 VBIEscCol129921_0062 # PDB 1Q8I X-ray; 2.00 A; A=1-783 # PDB 3K57 X-ray; 2.08 A; A=1-783 # PDB 3K58 X-ray; 2.05 A; A=1-783 # PDB 3K59 X-ray; 1.92 A; A=1-783 # PDB 3K5L X-ray; 2.70 A; A=1-783 # PDB 3K5M X-ray; 2.04 A; A=1-783 # PDB 3K5N X-ray; 3.15 A; A/B=1-783 # PDB 3K5O X-ray; 2.20 A; A/B=1-783 # PDB 3MAQ X-ray; 2.40 A; A=1-783 # PIR S15943 JDEC22 # PRINTS PR00106 DNAPOLB # PROSITE PS00116 DNA_POLYMERASE_B # Pfam PF00136 DNA_pol_B # Pfam PF03104 DNA_pol_B_exo1; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DPO2_ECOLI DNA polymerase II # RefSeq NP_414602 NC_000913.3 # RefSeq WP_000035670 NZ_LN832404.1 # SIMILARITY Belongs to the DNA polymerase type-B family. {ECO 0000305}. # SMART SM00486 POLBc # SUPFAM SSF53098 SSF53098 # eggNOG COG0417 LUCA # eggNOG ENOG4105CQ2 Bacteria BLAST swissprot:DPO2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DPO2_ECOLI BioCyc ECOL316407:JW0059-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0059-MONOMER BioCyc EcoCyc:EG10747-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10747-MONOMER BioCyc MetaCyc:EG10747-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10747-MONOMER COG COG0417 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0417 DOI 10.1007/BF00273583 http://dx.doi.org/10.1007/BF00273583 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.87.19.7663 http://dx.doi.org/10.1073/pnas.87.19.7663 DOI 10.1074/jbc.272.13.8611 http://dx.doi.org/10.1074/jbc.272.13.8611 DOI 10.1089/dna.1990.9.631 http://dx.doi.org/10.1089/dna.1990.9.631 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.7.7 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.7 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M35371 http://www.ebi.ac.uk/ena/data/view/M35371 EMBL M37727 http://www.ebi.ac.uk/ena/data/view/M37727 EMBL M38283 http://www.ebi.ac.uk/ena/data/view/M38283 EMBL M62646 http://www.ebi.ac.uk/ena/data/view/M62646 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X54847 http://www.ebi.ac.uk/ena/data/view/X54847 ENZYME 2.7.7.7 http://enzyme.expasy.org/EC/2.7.7.7 EchoBASE EB0740 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0740 EcoGene EG10747 http://www.ecogene.org/geneInfo.php?eg_id=EG10747 EnsemblBacteria AAC73171 http://www.ensemblgenomes.org/id/AAC73171 EnsemblBacteria AAC73171 http://www.ensemblgenomes.org/id/AAC73171 EnsemblBacteria BAB96628 http://www.ensemblgenomes.org/id/BAB96628 EnsemblBacteria BAB96628 http://www.ensemblgenomes.org/id/BAB96628 EnsemblBacteria BAB96628 http://www.ensemblgenomes.org/id/BAB96628 EnsemblBacteria b0060 http://www.ensemblgenomes.org/id/b0060 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000166 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000166 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003887 GO_function GO:0008296 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008296 GO_process GO:0006261 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006261 GO_process GO:0009432 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009432 GO_process GO:0045004 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045004 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.30.420.10 http://www.cathdb.info/version/latest/superfamily/3.30.420.10 Gene3D 3.90.1600.10 http://www.cathdb.info/version/latest/superfamily/3.90.1600.10 GeneID 944779 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944779 HOGENOM HOG000221829 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000221829&db=HOGENOM6 InParanoid P21189 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P21189 IntAct P21189 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P21189* IntEnz 2.7.7.7 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.7 InterPro IPR006133 http://www.ebi.ac.uk/interpro/entry/IPR006133 InterPro IPR006134 http://www.ebi.ac.uk/interpro/entry/IPR006134 InterPro IPR006172 http://www.ebi.ac.uk/interpro/entry/IPR006172 InterPro IPR012337 http://www.ebi.ac.uk/interpro/entry/IPR012337 InterPro IPR017964 http://www.ebi.ac.uk/interpro/entry/IPR017964 InterPro IPR023211 http://www.ebi.ac.uk/interpro/entry/IPR023211 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW0059 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0059 KEGG_Gene eco:b0060 http://www.genome.jp/dbget-bin/www_bget?eco:b0060 KEGG_Orthology KO:K02336 http://www.genome.jp/dbget-bin/www_bget?KO:K02336 OMA KAIDNPW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KAIDNPW PDB 1Q8I http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q8I PDB 3K57 http://www.ebi.ac.uk/pdbe-srv/view/entry/3K57 PDB 3K58 http://www.ebi.ac.uk/pdbe-srv/view/entry/3K58 PDB 3K59 http://www.ebi.ac.uk/pdbe-srv/view/entry/3K59 PDB 3K5L http://www.ebi.ac.uk/pdbe-srv/view/entry/3K5L PDB 3K5M http://www.ebi.ac.uk/pdbe-srv/view/entry/3K5M PDB 3K5N http://www.ebi.ac.uk/pdbe-srv/view/entry/3K5N PDB 3K5O http://www.ebi.ac.uk/pdbe-srv/view/entry/3K5O PDB 3MAQ http://www.ebi.ac.uk/pdbe-srv/view/entry/3MAQ PDBsum 1Q8I http://www.ebi.ac.uk/pdbsum/1Q8I PDBsum 3K57 http://www.ebi.ac.uk/pdbsum/3K57 PDBsum 3K58 http://www.ebi.ac.uk/pdbsum/3K58 PDBsum 3K59 http://www.ebi.ac.uk/pdbsum/3K59 PDBsum 3K5L http://www.ebi.ac.uk/pdbsum/3K5L PDBsum 3K5M http://www.ebi.ac.uk/pdbsum/3K5M PDBsum 3K5N http://www.ebi.ac.uk/pdbsum/3K5N PDBsum 3K5O http://www.ebi.ac.uk/pdbsum/3K5O PDBsum 3MAQ http://www.ebi.ac.uk/pdbsum/3MAQ PRINTS PR00106 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00106 PROSITE PS00116 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00116 PSORT swissprot:DPO2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DPO2_ECOLI PSORT-B swissprot:DPO2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DPO2_ECOLI PSORT2 swissprot:DPO2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DPO2_ECOLI Pfam PF00136 http://pfam.xfam.org/family/PF00136 Pfam PF03104 http://pfam.xfam.org/family/PF03104 Phobius swissprot:DPO2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DPO2_ECOLI PhylomeDB P21189 http://phylomedb.org/?seqid=P21189 ProteinModelPortal P21189 http://www.proteinmodelportal.org/query/uniprot/P21189 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2034216 http://www.ncbi.nlm.nih.gov/pubmed/2034216 PubMed 2217198 http://www.ncbi.nlm.nih.gov/pubmed/2217198 PubMed 2261080 http://www.ncbi.nlm.nih.gov/pubmed/2261080 PubMed 9079692 http://www.ncbi.nlm.nih.gov/pubmed/9079692 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414602 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414602 RefSeq WP_000035670 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000035670 SMART SM00486 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00486 SMR P21189 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P21189 STRING 511145.b0060 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0060&targetmode=cogs STRING COG0417 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0417&targetmode=cogs SUPFAM SSF53098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098 UniProtKB DPO2_ECOLI http://www.uniprot.org/uniprot/DPO2_ECOLI UniProtKB-AC P21189 http://www.uniprot.org/uniprot/P21189 charge swissprot:DPO2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DPO2_ECOLI eggNOG COG0417 http://eggnogapi.embl.de/nog_data/html/tree/COG0417 eggNOG ENOG4105CQ2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CQ2 epestfind swissprot:DPO2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DPO2_ECOLI garnier swissprot:DPO2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DPO2_ECOLI helixturnhelix swissprot:DPO2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DPO2_ECOLI hmoment swissprot:DPO2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DPO2_ECOLI iep swissprot:DPO2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DPO2_ECOLI inforesidue swissprot:DPO2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DPO2_ECOLI octanol swissprot:DPO2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DPO2_ECOLI pepcoil swissprot:DPO2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DPO2_ECOLI pepdigest swissprot:DPO2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DPO2_ECOLI pepinfo swissprot:DPO2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DPO2_ECOLI pepnet swissprot:DPO2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DPO2_ECOLI pepstats swissprot:DPO2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DPO2_ECOLI pepwheel swissprot:DPO2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DPO2_ECOLI pepwindow swissprot:DPO2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DPO2_ECOLI sigcleave swissprot:DPO2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DPO2_ECOLI ## Database ID URL or Descriptions # BioGrid 4262749 3 # EcoGene EG10313 fimF # FUNCTION FIMF_ECOLI Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Involved in the integration of FimH in the fimbriae. # GO_component GO:0009289 pilus; IEA:UniProtKB-SubCell. # GO_process GO:0007155 cell adhesion; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0007155 cell adhesion # Gene3D 2.60.40.1090 -; 1. # InterPro IPR000259 Adhesion_dom_fimbrial # InterPro IPR008966 Adhesion_dom # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Brite ko02044 Secretion system # Organism FIMF_ECOLI Escherichia coli (strain K12) # PATRIC 32124232 VBIEscCol129921_4459 # PDB 2JMR NMR; -; A=23-176 # PDB 3BFQ X-ray; 1.34 A; F=23-37 # PDB 3BFW X-ray; 1.80 A; B/D=23-37 # PDB 3BWU X-ray; 1.76 A; F=35-176 # PDB 3JWN X-ray; 2.69 A; E/F/K/L=23-176 # PDB 4J3O X-ray; 3.80 A; F=23-176 # PDB 4XOB X-ray; 3.00 A; B/D/F/H=23-37 # PDB 5IQM X-ray; 1.50 A; B/F=23-37 # PDB 5IQN X-ray; 1.00 A; B/F=25-34 # PDB 5IQO X-ray; 1.30 A; B/D=23-37 # PIR S56543 S56543 # Pfam PF00419 Fimbrial # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FIMF_ECOLI Protein FimF # RefSeq NP_418738 NC_000913.3 # RefSeq WP_001244827 NZ_LN832404.1 # SIMILARITY Belongs to the fimbrial protein family. {ECO 0000305}. # SUBCELLULAR LOCATION FIMF_ECOLI Fimbrium. # SUPFAM SSF49401 SSF49401 # eggNOG ENOG4108SQA Bacteria # eggNOG ENOG4111HFM LUCA BLAST swissprot:FIMF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FIMF_ECOLI BioCyc ECOL316407:JW4281-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4281-MONOMER BioCyc EcoCyc:EG10313-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10313-MONOMER COG COG3539 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3539 DIP DIP-9614N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9614N DOI 10.1007/BF00260505 http://dx.doi.org/10.1007/BF00260505 DOI 10.1007/BF00328136 http://dx.doi.org/10.1007/BF00328136 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X05672 http://www.ebi.ac.uk/ena/data/view/X05672 EMBL X51655 http://www.ebi.ac.uk/ena/data/view/X51655 EchoBASE EB0309 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0309 EcoGene EG10313 http://www.ecogene.org/geneInfo.php?eg_id=EG10313 EnsemblBacteria AAC77274 http://www.ensemblgenomes.org/id/AAC77274 EnsemblBacteria AAC77274 http://www.ensemblgenomes.org/id/AAC77274 EnsemblBacteria BAE78311 http://www.ensemblgenomes.org/id/BAE78311 EnsemblBacteria BAE78311 http://www.ensemblgenomes.org/id/BAE78311 EnsemblBacteria BAE78311 http://www.ensemblgenomes.org/id/BAE78311 EnsemblBacteria b4318 http://www.ensemblgenomes.org/id/b4318 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009289 GO_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 Gene3D 2.60.40.1090 http://www.cathdb.info/version/latest/superfamily/2.60.40.1090 GeneID 948845 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948845 HOGENOM HOG000260127 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260127&db=HOGENOM6 InParanoid P08189 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P08189 IntAct P08189 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P08189* InterPro IPR000259 http://www.ebi.ac.uk/interpro/entry/IPR000259 InterPro IPR008966 http://www.ebi.ac.uk/interpro/entry/IPR008966 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW4281 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4281 KEGG_Gene eco:b4318 http://www.genome.jp/dbget-bin/www_bget?eco:b4318 KEGG_Orthology KO:K07348 http://www.genome.jp/dbget-bin/www_bget?KO:K07348 MINT MINT-6491069 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-6491069 OMA YVRDNAC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YVRDNAC PDB 2JMR http://www.ebi.ac.uk/pdbe-srv/view/entry/2JMR PDB 3BFQ http://www.ebi.ac.uk/pdbe-srv/view/entry/3BFQ PDB 3BFW http://www.ebi.ac.uk/pdbe-srv/view/entry/3BFW PDB 3BWU http://www.ebi.ac.uk/pdbe-srv/view/entry/3BWU PDB 3JWN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JWN PDB 4J3O http://www.ebi.ac.uk/pdbe-srv/view/entry/4J3O PDB 4XOB http://www.ebi.ac.uk/pdbe-srv/view/entry/4XOB PDB 5IQM http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQM PDB 5IQN http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQN PDB 5IQO http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQO PDBsum 2JMR http://www.ebi.ac.uk/pdbsum/2JMR PDBsum 3BFQ http://www.ebi.ac.uk/pdbsum/3BFQ PDBsum 3BFW http://www.ebi.ac.uk/pdbsum/3BFW PDBsum 3BWU http://www.ebi.ac.uk/pdbsum/3BWU PDBsum 3JWN http://www.ebi.ac.uk/pdbsum/3JWN PDBsum 4J3O http://www.ebi.ac.uk/pdbsum/4J3O PDBsum 4XOB http://www.ebi.ac.uk/pdbsum/4XOB PDBsum 5IQM http://www.ebi.ac.uk/pdbsum/5IQM PDBsum 5IQN http://www.ebi.ac.uk/pdbsum/5IQN PDBsum 5IQO http://www.ebi.ac.uk/pdbsum/5IQO PSORT swissprot:FIMF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FIMF_ECOLI PSORT-B swissprot:FIMF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FIMF_ECOLI PSORT2 swissprot:FIMF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FIMF_ECOLI Pfam PF00419 http://pfam.xfam.org/family/PF00419 Phobius swissprot:FIMF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FIMF_ECOLI PhylomeDB P08189 http://phylomedb.org/?seqid=P08189 ProteinModelPortal P08189 http://www.proteinmodelportal.org/query/uniprot/P08189 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1970114 http://www.ncbi.nlm.nih.gov/pubmed/1970114 PubMed 2890081 http://www.ncbi.nlm.nih.gov/pubmed/2890081 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418738 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418738 RefSeq WP_001244827 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001244827 SMR P08189 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P08189 STRING 511145.b4318 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4318&targetmode=cogs STRING COG3539 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3539&targetmode=cogs SUPFAM SSF49401 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49401 UniProtKB FIMF_ECOLI http://www.uniprot.org/uniprot/FIMF_ECOLI UniProtKB-AC P08189 http://www.uniprot.org/uniprot/P08189 charge swissprot:FIMF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FIMF_ECOLI eggNOG ENOG4108SQA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108SQA eggNOG ENOG4111HFM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111HFM epestfind swissprot:FIMF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FIMF_ECOLI garnier swissprot:FIMF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FIMF_ECOLI helixturnhelix swissprot:FIMF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FIMF_ECOLI hmoment swissprot:FIMF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FIMF_ECOLI iep swissprot:FIMF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FIMF_ECOLI inforesidue swissprot:FIMF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FIMF_ECOLI octanol swissprot:FIMF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FIMF_ECOLI pepcoil swissprot:FIMF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FIMF_ECOLI pepdigest swissprot:FIMF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FIMF_ECOLI pepinfo swissprot:FIMF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FIMF_ECOLI pepnet swissprot:FIMF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FIMF_ECOLI pepstats swissprot:FIMF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FIMF_ECOLI pepwheel swissprot:FIMF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FIMF_ECOLI pepwindow swissprot:FIMF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FIMF_ECOLI sigcleave swissprot:FIMF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FIMF_ECOLI ## Database ID URL or Descriptions # BioGrid 4260554 2 # CAUTION DSDX_ECOLI An ORF called dsdC was originally (PubMed 3275618) assigned to the wrong DNA strand and thought to be a D-serine deaminase activator, it was then resequenced by Ref.2 and still thought to be "dsdC", but this time to function as a D-serine permease. It is PubMed 7592420 that showed that dsdC is another gene and that this sequence should be called dsdX. It should also be noted that the C-terminal part of dsdX (from 338 onward) was also sequenced (PubMed 3029015 and PubMed 1659648) and was thought to be a separate ORF (don't worry, we also had difficulties understanding what happened!). {ECO 0000305|PubMed 3275618}. # EcoGene EG10250 dsdX # FUNCTION DSDX_ECOLI Probable permease for an unknown substrate. {ECO 0000269|PubMed 7592420}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoliWiki. # GO_function GO:0015128 gluconate transmembrane transporter activity; IBA:GO_Central. # GO_function GO:0042945 D-serine transmembrane transporter activity; ISS:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0042942 D-serine transport; ISS:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0006950 response to stress # InterPro IPR003474 Glcn_transporter # KEGG_Brite ko02000 Transporters # Organism DSDX_ECOLI Escherichia coli (strain K12) # PATRIC 32120109 VBIEscCol129921_2463 # PIR S54140 S54140 # PIRSF PIRSF002746 Gluconate_transporter # Pfam PF02447 GntP_permease # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DSDX_ECOLI DsdX permease # RefSeq NP_416866 NC_000913.3 # RefSeq WP_000556048 NZ_LN832404.1 # SIMILARITY Belongs to the GntP permease family. {ECO 0000305}. # SUBCELLULAR LOCATION DSDX_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.8.1:the gluconate h(+) symporter (gntp) family # TIGRFAMs TIGR00791 gntP # eggNOG COG2610 LUCA # eggNOG ENOG4105C6Z Bacteria BLAST swissprot:DSDX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DSDX_ECOLI BioCyc ECOL316407:JW2362-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2362-MONOMER BioCyc EcoCyc:DSDX-MONOMER http://biocyc.org/getid?id=EcoCyc:DSDX-MONOMER COG COG2610 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2610 DIP DIP-9481N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9481N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1365-2958.1991.tb01880.x http://dx.doi.org/10.1111/j.1365-2958.1991.tb01880.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.19.5307-5316.2002 http://dx.doi.org/10.1128/JB.184.19.5307-5316.2002 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01603 http://www.ebi.ac.uk/ena/data/view/J01603 EMBL M19035 http://www.ebi.ac.uk/ena/data/view/M19035 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X81461 http://www.ebi.ac.uk/ena/data/view/X81461 EMBL X86379 http://www.ebi.ac.uk/ena/data/view/X86379 EMBL X91821 http://www.ebi.ac.uk/ena/data/view/X91821 EchoBASE EB0246 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0246 EcoGene EG10250 http://www.ecogene.org/geneInfo.php?eg_id=EG10250 EnsemblBacteria AAC75424 http://www.ensemblgenomes.org/id/AAC75424 EnsemblBacteria AAC75424 http://www.ensemblgenomes.org/id/AAC75424 EnsemblBacteria BAA16225 http://www.ensemblgenomes.org/id/BAA16225 EnsemblBacteria BAA16225 http://www.ensemblgenomes.org/id/BAA16225 EnsemblBacteria BAA16225 http://www.ensemblgenomes.org/id/BAA16225 EnsemblBacteria b2365 http://www.ensemblgenomes.org/id/b2365 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015128 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015128 GO_function GO:0042945 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042945 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0042942 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042942 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 949103 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949103 HOGENOM HOG000237115 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000237115&db=HOGENOM6 InParanoid P08555 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P08555 IntAct P08555 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P08555* InterPro IPR003474 http://www.ebi.ac.uk/interpro/entry/IPR003474 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2362 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2362 KEGG_Gene eco:b2365 http://www.genome.jp/dbget-bin/www_bget?eco:b2365 KEGG_Orthology KO:K13629 http://www.genome.jp/dbget-bin/www_bget?KO:K13629 MINT MINT-1235614 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1235614 OMA MESQIWV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MESQIWV PSORT swissprot:DSDX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DSDX_ECOLI PSORT-B swissprot:DSDX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DSDX_ECOLI PSORT2 swissprot:DSDX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DSDX_ECOLI Pfam PF02447 http://pfam.xfam.org/family/PF02447 Phobius swissprot:DSDX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DSDX_ECOLI PhylomeDB P08555 http://phylomedb.org/?seqid=P08555 ProteinModelPortal P08555 http://www.proteinmodelportal.org/query/uniprot/P08555 PubMed 12218016 http://www.ncbi.nlm.nih.gov/pubmed/12218016 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 1659648 http://www.ncbi.nlm.nih.gov/pubmed/1659648 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3029015 http://www.ncbi.nlm.nih.gov/pubmed/3029015 PubMed 3275618 http://www.ncbi.nlm.nih.gov/pubmed/3275618 PubMed 7592420 http://www.ncbi.nlm.nih.gov/pubmed/7592420 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416866 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416866 RefSeq WP_000556048 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000556048 STRING 511145.b2365 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2365&targetmode=cogs STRING COG2610 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2610&targetmode=cogs TCDB 2.A.8.1 http://www.tcdb.org/search/result.php?tc=2.A.8.1 TIGRFAMs TIGR00791 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00791 UniProtKB DSDX_ECOLI http://www.uniprot.org/uniprot/DSDX_ECOLI UniProtKB-AC P08555 http://www.uniprot.org/uniprot/P08555 charge swissprot:DSDX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DSDX_ECOLI eggNOG COG2610 http://eggnogapi.embl.de/nog_data/html/tree/COG2610 eggNOG ENOG4105C6Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C6Z epestfind swissprot:DSDX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DSDX_ECOLI garnier swissprot:DSDX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DSDX_ECOLI helixturnhelix swissprot:DSDX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DSDX_ECOLI hmoment swissprot:DSDX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DSDX_ECOLI iep swissprot:DSDX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DSDX_ECOLI inforesidue swissprot:DSDX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DSDX_ECOLI octanol swissprot:DSDX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DSDX_ECOLI pepcoil swissprot:DSDX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DSDX_ECOLI pepdigest swissprot:DSDX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DSDX_ECOLI pepinfo swissprot:DSDX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DSDX_ECOLI pepnet swissprot:DSDX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DSDX_ECOLI pepstats swissprot:DSDX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DSDX_ECOLI pepwheel swissprot:DSDX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DSDX_ECOLI pepwindow swissprot:DSDX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DSDX_ECOLI sigcleave swissprot:DSDX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DSDX_ECOLI ## Database ID URL or Descriptions # BioGrid 4259417 167 # EcoGene EG12981 yggU # Gene3D 3.30.1200.10 -; 1. # HAMAP MF_00634 UPF0235 # IntAct P52060 3 # InterPro IPR003746 DUF167 # InterPro IPR005228 CHP00251 # Organism YGGU_ECOLI Escherichia coli (strain K12) # PATRIC 32121318 VBIEscCol129921_3047 # PIR H65080 H65080 # Pfam PF02594 DUF167 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UPF0235 protein YggU {ECO:0000255|HAMAP-Rule MF_00634} # RefSeq NP_417428 NC_000913.3 # RefSeq WP_000994920 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA69120.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the UPF0235 family. {ECO:0000255|HAMAP- Rule MF_00634}. # SMART SM01152 DUF167 # SUPFAM SSF69786 SSF69786 # TIGRFAMs TIGR00251 TIGR00251 # eggNOG COG1872 LUCA # eggNOG ENOG4105VZ9 Bacteria BLAST swissprot:YGGU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGGU_ECOLI BioCyc ECOL316407:JW5479-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5479-MONOMER BioCyc EcoCyc:G7529-MONOMER http://biocyc.org/getid?id=EcoCyc:G7529-MONOMER COG COG1872 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1872 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2806 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2806 EcoGene EG12981 http://www.ecogene.org/geneInfo.php?eg_id=EG12981 EnsemblBacteria AAC75990 http://www.ensemblgenomes.org/id/AAC75990 EnsemblBacteria AAC75990 http://www.ensemblgenomes.org/id/AAC75990 EnsemblBacteria BAE77016 http://www.ensemblgenomes.org/id/BAE77016 EnsemblBacteria BAE77016 http://www.ensemblgenomes.org/id/BAE77016 EnsemblBacteria BAE77016 http://www.ensemblgenomes.org/id/BAE77016 EnsemblBacteria b2953 http://www.ensemblgenomes.org/id/b2953 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.30.1200.10 http://www.cathdb.info/version/latest/superfamily/3.30.1200.10 GeneID 947424 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947424 HAMAP MF_00634 http://hamap.expasy.org/unirule/MF_00634 HOGENOM HOG000019208 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000019208&db=HOGENOM6 InParanoid P52060 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P52060 IntAct P52060 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P52060* InterPro IPR003746 http://www.ebi.ac.uk/interpro/entry/IPR003746 InterPro IPR005228 http://www.ebi.ac.uk/interpro/entry/IPR005228 KEGG_Gene ecj:JW5479 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5479 KEGG_Gene eco:b2953 http://www.genome.jp/dbget-bin/www_bget?eco:b2953 KEGG_Orthology KO:K09131 http://www.genome.jp/dbget-bin/www_bget?KO:K09131 OMA EFAGLHG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EFAGLHG PSORT swissprot:YGGU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGGU_ECOLI PSORT-B swissprot:YGGU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGGU_ECOLI PSORT2 swissprot:YGGU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGGU_ECOLI Pfam PF02594 http://pfam.xfam.org/family/PF02594 Phobius swissprot:YGGU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGGU_ECOLI PhylomeDB P52060 http://phylomedb.org/?seqid=P52060 ProteinModelPortal P52060 http://www.proteinmodelportal.org/query/uniprot/P52060 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417428 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417428 RefSeq WP_000994920 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000994920 SMART SM01152 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01152 SMR P52060 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P52060 STRING 511145.b2953 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2953&targetmode=cogs STRING COG1872 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1872&targetmode=cogs SUPFAM SSF69786 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF69786 TIGRFAMs TIGR00251 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00251 UniProtKB YGGU_ECOLI http://www.uniprot.org/uniprot/YGGU_ECOLI UniProtKB-AC P52060 http://www.uniprot.org/uniprot/P52060 charge swissprot:YGGU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGGU_ECOLI eggNOG COG1872 http://eggnogapi.embl.de/nog_data/html/tree/COG1872 eggNOG ENOG4105VZ9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VZ9 epestfind swissprot:YGGU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGGU_ECOLI garnier swissprot:YGGU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGGU_ECOLI helixturnhelix swissprot:YGGU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGGU_ECOLI hmoment swissprot:YGGU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGGU_ECOLI iep swissprot:YGGU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGGU_ECOLI inforesidue swissprot:YGGU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGGU_ECOLI octanol swissprot:YGGU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGGU_ECOLI pepcoil swissprot:YGGU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGGU_ECOLI pepdigest swissprot:YGGU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGGU_ECOLI pepinfo swissprot:YGGU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGGU_ECOLI pepnet swissprot:YGGU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGGU_ECOLI pepstats swissprot:YGGU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGGU_ECOLI pepwheel swissprot:YGGU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGGU_ECOLI pepwindow swissprot:YGGU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGGU_ECOLI sigcleave swissprot:YGGU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGGU_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES DCDA_ECOLI Kinetic parameters KM=1.7 mM for meso-2,6-diaminoheptanedioate (at pH 6.8 and 37 degrees Celsius) {ECO 0000269|PubMed 14343156}; KM=1.07 mM for meso-2,6-diaminoheptanedioate (at pH 8) {ECO 0000269|PubMed 18508763}; pH dependence Optimum pH is 6.7-6.8. {ECO 0000269|PubMed 14343156}; # BioGrid 4261891 8 # CATALYTIC ACTIVITY DCDA_ECOLI Meso-2,6-diaminoheptanedioate = L-lysine + CO(2). {ECO 0000269|PubMed 11856852, ECO 0000269|PubMed 14343156, ECO 0000269|PubMed 18508763}. # CDD cd06828 PLPDE_III_DapDC # COFACTOR DCDA_ECOLI Name=pyridoxal 5'-phosphate; Xref=ChEBI CHEBI 597326; Evidence={ECO 0000269|PubMed 11856852, ECO 0000269|PubMed 14343156}; # ENZYME REGULATION Is activated by 2,3-dimercaptopropan-1-ol. {ECO:0000269|PubMed 14343156}. # EcoGene EG10549 lysA # FUNCTION DCDA_ECOLI Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. Is not active against the DD- or LL-isomers of diaminopimelate. {ECO 0000269|PubMed 11856852, ECO 0000269|PubMed 14343156, ECO 0000269|PubMed 18508763}. # GO_function GO:0008836 diaminopimelate decarboxylase activity; IDA:EcoCyc. # GO_function GO:0030170 pyridoxal phosphate binding; IEA:UniProtKB-HAMAP. # GO_process GO:0009089 lysine biosynthetic process via diaminopimelate; IEA:UniProtKB-HAMAP. # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 2.40.37.10 -; 1. # Gene3D 3.20.20.10 -; 1. # HAMAP MF_02120 LysA # INDUCTION DCDA_ECOLI Up-regulated by LysR. Repressed in the presence of lysine. {ECO 0000269|PubMed 6411928, ECO 0000269|PubMed 6417111}. # INTERACTION DCDA_ECOLI P0AE88 cpxR; NbExp=2; IntAct=EBI-553837, EBI-550918; # IntAct P00861 9 # InterPro IPR000183 Orn/DAP/Arg_de-COase # InterPro IPR002986 DAP_deCOOHase_LysA # InterPro IPR009006 Ala_racemase/Decarboxylase_C # InterPro IPR022643 De-COase2_C # InterPro IPR022644 De-COase2_N # InterPro IPR022653 De-COase2_pyr-phos_BS # InterPro IPR022657 De-COase2_CS # InterPro IPR029066 PLP-binding_barrel # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00300 Lysine biosynthesis # Organism DCDA_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1. {ECO 0000269|PubMed:14343156}. # PATRIC 32121094 VBIEscCol129921_2936 # PDB 1KNW X-ray; 2.10 A; A=1-420 # PDB 1KO0 X-ray; 2.20 A; A=1-420 # PIR A01078 DCECD # PRINTS PR01179 ODADCRBXLASE # PRINTS PR01181 DAPDCRBXLASE # PROSITE PS00878 ODR_DC_2_1 # PROSITE PS00879 ODR_DC_2_2 # Pfam PF00278 Orn_DAP_Arg_deC # Pfam PF02784 Orn_Arg_deC_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Diaminopimelate decarboxylase {ECO:0000255|HAMAP-Rule MF_02120} # RefSeq NP_417315 NC_000913.3 # RefSeq WP_001120711 NZ_LN832404.1 # SIMILARITY Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily. {ECO:0000255|HAMAP-Rule MF_02120}. # SUPFAM SSF50621 SSF50621 # SUPFAM SSF51419 SSF51419 # TIGRFAMs TIGR01048 lysA # UniPathway UPA00034 UER00027 # eggNOG COG0019 LUCA # eggNOG ENOG4105CU5 Bacteria BLAST swissprot:DCDA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DCDA_ECOLI BioCyc ECOL316407:JW2806-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2806-MONOMER BioCyc EcoCyc:DIAMINOPIMDECARB-MONOMER http://biocyc.org/getid?id=EcoCyc:DIAMINOPIMDECARB-MONOMER BioCyc MetaCyc:DIAMINOPIMDECARB-MONOMER http://biocyc.org/getid?id=MetaCyc:DIAMINOPIMDECARB-MONOMER COG COG0019 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0019 DIP DIP-10132N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10132N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/S0022-2836(83)80020-5 http://dx.doi.org/10.1016/S0022-2836(83)80020-5 DOI 10.1016/S0022-2836(83)80021-7 http://dx.doi.org/10.1016/S0022-2836(83)80021-7 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj0960075 http://dx.doi.org/10.1042/bj0960075 DOI 10.1074/jbc.M801823200 http://dx.doi.org/10.1074/jbc.M801823200 DOI 10.1107/S0907444902000148 http://dx.doi.org/10.1107/S0907444902000148 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.1.1.20 {ECO:0000255|HAMAP-Rule:MF_02120, ECO:0000269|PubMed:11856852, ECO:0000269|PubMed:14343156, ECO:0000269|PubMed:18508763} http://www.genome.jp/dbget-bin/www_bget?EC:4.1.1.20 {ECO:0000255|HAMAP-Rule:MF_02120, ECO:0000269|PubMed:11856852, ECO:0000269|PubMed:14343156, ECO:0000269|PubMed:18508763} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01614 http://www.ebi.ac.uk/ena/data/view/J01614 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 ENZYME 4.1.1.20 {ECO:0000255|HAMAP-Rule:MF_02120, ECO:0000269|PubMed:11856852, ECO:0000269|PubMed:14343156, ECO:0000269|PubMed:18508763} http://enzyme.expasy.org/EC/4.1.1.20 {ECO:0000255|HAMAP-Rule:MF_02120, ECO:0000269|PubMed:11856852, ECO:0000269|PubMed:14343156, ECO:0000269|PubMed:18508763} EchoBASE EB0544 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0544 EcoGene EG10549 http://www.ecogene.org/geneInfo.php?eg_id=EG10549 EnsemblBacteria AAC75877 http://www.ensemblgenomes.org/id/AAC75877 EnsemblBacteria AAC75877 http://www.ensemblgenomes.org/id/AAC75877 EnsemblBacteria BAE76907 http://www.ensemblgenomes.org/id/BAE76907 EnsemblBacteria BAE76907 http://www.ensemblgenomes.org/id/BAE76907 EnsemblBacteria BAE76907 http://www.ensemblgenomes.org/id/BAE76907 EnsemblBacteria b2838 http://www.ensemblgenomes.org/id/b2838 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008836 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008836 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_process GO:0009089 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009089 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 2.40.37.10 http://www.cathdb.info/version/latest/superfamily/2.40.37.10 Gene3D 3.20.20.10 http://www.cathdb.info/version/latest/superfamily/3.20.20.10 GeneID 947313 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947313 HAMAP MF_02120 http://hamap.expasy.org/unirule/MF_02120 HOGENOM HOG000045070 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000045070&db=HOGENOM6 InParanoid P00861 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00861 IntAct P00861 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00861* IntEnz 4.1.1.20 {ECO:0000255|HAMAP-Rule:MF_02120, ECO:0000269|PubMed:11856852, ECO:0000269|PubMed:14343156, ECO:0000269|PubMed:18508763} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.1.20 {ECO:0000255|HAMAP-Rule:MF_02120, ECO:0000269|PubMed:11856852, ECO:0000269|PubMed:14343156, ECO:0000269|PubMed:18508763} InterPro IPR000183 http://www.ebi.ac.uk/interpro/entry/IPR000183 InterPro IPR002986 http://www.ebi.ac.uk/interpro/entry/IPR002986 InterPro IPR009006 http://www.ebi.ac.uk/interpro/entry/IPR009006 InterPro IPR022643 http://www.ebi.ac.uk/interpro/entry/IPR022643 InterPro IPR022644 http://www.ebi.ac.uk/interpro/entry/IPR022644 InterPro IPR022653 http://www.ebi.ac.uk/interpro/entry/IPR022653 InterPro IPR022657 http://www.ebi.ac.uk/interpro/entry/IPR022657 InterPro IPR029066 http://www.ebi.ac.uk/interpro/entry/IPR029066 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2806 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2806 KEGG_Gene eco:b2838 http://www.genome.jp/dbget-bin/www_bget?eco:b2838 KEGG_Orthology KO:K01586 http://www.genome.jp/dbget-bin/www_bget?KO:K01586 KEGG_Pathway ko00300 http://www.genome.jp/kegg-bin/show_pathway?ko00300 KEGG_Reaction rn:R00451 http://www.genome.jp/dbget-bin/www_bget?rn:R00451 MINT MINT-1292495 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1292495 OMA NISVGHI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NISVGHI PDB 1KNW http://www.ebi.ac.uk/pdbe-srv/view/entry/1KNW PDB 1KO0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1KO0 PDBsum 1KNW http://www.ebi.ac.uk/pdbsum/1KNW PDBsum 1KO0 http://www.ebi.ac.uk/pdbsum/1KO0 PRINTS PR01179 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01179 PRINTS PR01181 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01181 PROSITE PS00878 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00878 PROSITE PS00879 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00879 PSORT swissprot:DCDA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DCDA_ECOLI PSORT-B swissprot:DCDA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DCDA_ECOLI PSORT2 swissprot:DCDA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DCDA_ECOLI Pfam PF00278 http://pfam.xfam.org/family/PF00278 Pfam PF02784 http://pfam.xfam.org/family/PF02784 Phobius swissprot:DCDA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DCDA_ECOLI PhylomeDB P00861 http://phylomedb.org/?seqid=P00861 ProteinModelPortal P00861 http://www.proteinmodelportal.org/query/uniprot/P00861 PubMed 11856852 http://www.ncbi.nlm.nih.gov/pubmed/11856852 PubMed 14343156 http://www.ncbi.nlm.nih.gov/pubmed/14343156 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18508763 http://www.ncbi.nlm.nih.gov/pubmed/18508763 PubMed 6350601 http://www.ncbi.nlm.nih.gov/pubmed/6350601 PubMed 6411928 http://www.ncbi.nlm.nih.gov/pubmed/6411928 PubMed 6417111 http://www.ncbi.nlm.nih.gov/pubmed/6417111 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417315 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417315 RefSeq WP_001120711 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001120711 SMR P00861 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00861 STRING 511145.b2838 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2838&targetmode=cogs STRING COG0019 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0019&targetmode=cogs SUPFAM SSF50621 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50621 SUPFAM SSF51419 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51419 SWISS-2DPAGE P00861 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P00861 TIGRFAMs TIGR01048 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01048 UniProtKB DCDA_ECOLI http://www.uniprot.org/uniprot/DCDA_ECOLI UniProtKB-AC P00861 http://www.uniprot.org/uniprot/P00861 charge swissprot:DCDA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DCDA_ECOLI eggNOG COG0019 http://eggnogapi.embl.de/nog_data/html/tree/COG0019 eggNOG ENOG4105CU5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CU5 epestfind swissprot:DCDA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DCDA_ECOLI garnier swissprot:DCDA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DCDA_ECOLI helixturnhelix swissprot:DCDA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DCDA_ECOLI hmoment swissprot:DCDA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DCDA_ECOLI iep swissprot:DCDA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DCDA_ECOLI inforesidue swissprot:DCDA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DCDA_ECOLI octanol swissprot:DCDA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DCDA_ECOLI pepcoil swissprot:DCDA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DCDA_ECOLI pepdigest swissprot:DCDA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DCDA_ECOLI pepinfo swissprot:DCDA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DCDA_ECOLI pepnet swissprot:DCDA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DCDA_ECOLI pepstats swissprot:DCDA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DCDA_ECOLI pepwheel swissprot:DCDA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DCDA_ECOLI pepwindow swissprot:DCDA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DCDA_ECOLI sigcleave swissprot:DCDA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DCDA_ECOLI ## Database ID URL or Descriptions # BRENDA 4.1.1.17 2026 # BioGrid 4262354 4 # CATALYTIC ACTIVITY DCOR_ECOLI L-ornithine = putrescine + CO(2). # CDD cd00615 Orn_deC_like # COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI 597326; # EcoGene EG10961 speC # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004586 ornithine decarboxylase activity; IDA:EcoCyc. # GO_function GO:0030170 pyridoxal phosphate binding; IDA:EcoCyc. # GO_process GO:0008295 spermidine biosynthetic process; IMP:EcoCyc. # GO_process GO:0033387 putrescine biosynthetic process from ornithine; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.50.220 -; 1. # Gene3D 3.40.640.10 -; 1. # Gene3D 3.90.100.10 -; 1. # Gene3D 3.90.1150.10 -; 1. # InterPro IPR000310 Orn/Lys/Arg_deCO2ase_major_dom # InterPro IPR005308 OKR_de-COase_N # InterPro IPR008286 Prn/Lys/Arg_de-COase_C # InterPro IPR011006 CheY-like_superfamily # InterPro IPR011193 Orn/lys/arg_de-COase # InterPro IPR015421 PyrdxlP-dep_Trfase_major_sub1 # InterPro IPR015422 PyrdxlP-dep_Trfase_major_sub2 # InterPro IPR015424 PyrdxlP-dep_Trfase # InterPro IPR027464 Ornithine_deCO2ase_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00330 Arginine and proline metabolism # KEGG_Pathway ko00480 Glutathione metabolism # Organism DCOR_ECOLI Escherichia coli (strain K12) # PATHWAY Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine step 1/1. # PATRIC 32121346 VBIEscCol129921_3061 # PIR I60729 I60729 # PIRSF PIRSF009393 Orn_decarb # PROSITE PS00703 OKR_DC_1 # Pfam PF01276 OKR_DC_1 # Pfam PF03709 OKR_DC_1_N # Pfam PF03711 OKR_DC_1_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DCOR_ECOLI Ornithine decarboxylase, constitutive # RefSeq NP_417440 NC_000913.3 # RefSeq WP_001326492 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA66174.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAA69133.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the Orn/Lys/Arg decarboxylase class-I family. {ECO 0000305}. # SUPFAM SSF52172 SSF52172 # SUPFAM SSF53383 SSF53383 # SUPFAM SSF55904 SSF55904 # UniPathway UPA00535 UER00288 # eggNOG COG1982 LUCA # eggNOG ENOG4105CXN Bacteria BLAST swissprot:DCOR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DCOR_ECOLI BioCyc ECOL316407:JW5482-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5482-MONOMER BioCyc EcoCyc:ORNDECARBOX-BIO-MONOMER http://biocyc.org/getid?id=EcoCyc:ORNDECARBOX-BIO-MONOMER BioCyc MetaCyc:ORNDECARBOX-BIO-MONOMER http://biocyc.org/getid?id=MetaCyc:ORNDECARBOX-BIO-MONOMER COG COG1982 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1982 DIP DIP-10907N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10907N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.1.1.17 http://www.genome.jp/dbget-bin/www_bget?EC:4.1.1.17 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M33766 http://www.ebi.ac.uk/ena/data/view/M33766 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 ENZYME 4.1.1.17 http://enzyme.expasy.org/EC/4.1.1.17 EchoBASE EB0954 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0954 EcoGene EG10961 http://www.ecogene.org/geneInfo.php?eg_id=EG10961 EnsemblBacteria AAC76002 http://www.ensemblgenomes.org/id/AAC76002 EnsemblBacteria AAC76002 http://www.ensemblgenomes.org/id/AAC76002 EnsemblBacteria BAE77028 http://www.ensemblgenomes.org/id/BAE77028 EnsemblBacteria BAE77028 http://www.ensemblgenomes.org/id/BAE77028 EnsemblBacteria BAE77028 http://www.ensemblgenomes.org/id/BAE77028 EnsemblBacteria b2965 http://www.ensemblgenomes.org/id/b2965 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004586 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004586 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_process GO:0008295 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008295 GO_process GO:0033387 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033387 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.50.220 http://www.cathdb.info/version/latest/superfamily/3.40.50.220 Gene3D 3.40.640.10 http://www.cathdb.info/version/latest/superfamily/3.40.640.10 Gene3D 3.90.100.10 http://www.cathdb.info/version/latest/superfamily/3.90.100.10 Gene3D 3.90.1150.10 http://www.cathdb.info/version/latest/superfamily/3.90.1150.10 GeneID 947457 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947457 HOGENOM HOG000164393 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000164393&db=HOGENOM6 InParanoid P21169 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P21169 IntEnz 4.1.1.17 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.1.17 InterPro IPR000310 http://www.ebi.ac.uk/interpro/entry/IPR000310 InterPro IPR005308 http://www.ebi.ac.uk/interpro/entry/IPR005308 InterPro IPR008286 http://www.ebi.ac.uk/interpro/entry/IPR008286 InterPro IPR011006 http://www.ebi.ac.uk/interpro/entry/IPR011006 InterPro IPR011193 http://www.ebi.ac.uk/interpro/entry/IPR011193 InterPro IPR015421 http://www.ebi.ac.uk/interpro/entry/IPR015421 InterPro IPR015422 http://www.ebi.ac.uk/interpro/entry/IPR015422 InterPro IPR015424 http://www.ebi.ac.uk/interpro/entry/IPR015424 InterPro IPR027464 http://www.ebi.ac.uk/interpro/entry/IPR027464 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5482 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5482 KEGG_Gene eco:b2965 http://www.genome.jp/dbget-bin/www_bget?eco:b2965 KEGG_Orthology KO:K01581 http://www.genome.jp/dbget-bin/www_bget?KO:K01581 KEGG_Pathway ko00330 http://www.genome.jp/kegg-bin/show_pathway?ko00330 KEGG_Pathway ko00480 http://www.genome.jp/kegg-bin/show_pathway?ko00480 KEGG_Reaction rn:R00670 http://www.genome.jp/dbget-bin/www_bget?rn:R00670 OMA QYTEFGI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QYTEFGI PROSITE PS00703 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00703 PSORT swissprot:DCOR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DCOR_ECOLI PSORT-B swissprot:DCOR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DCOR_ECOLI PSORT2 swissprot:DCOR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DCOR_ECOLI Pfam PF01276 http://pfam.xfam.org/family/PF01276 Pfam PF03709 http://pfam.xfam.org/family/PF03709 Pfam PF03711 http://pfam.xfam.org/family/PF03711 Phobius swissprot:DCOR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DCOR_ECOLI PhylomeDB P21169 http://phylomedb.org/?seqid=P21169 ProteinModelPortal P21169 http://www.proteinmodelportal.org/query/uniprot/P21169 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417440 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417440 RefSeq WP_001326492 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001326492 SMR P21169 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P21169 STRING 511145.b2965 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2965&targetmode=cogs STRING COG1982 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1982&targetmode=cogs SUPFAM SSF52172 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52172 SUPFAM SSF53383 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53383 SUPFAM SSF55904 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55904 UniProtKB DCOR_ECOLI http://www.uniprot.org/uniprot/DCOR_ECOLI UniProtKB-AC P21169 http://www.uniprot.org/uniprot/P21169 charge swissprot:DCOR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DCOR_ECOLI eggNOG COG1982 http://eggnogapi.embl.de/nog_data/html/tree/COG1982 eggNOG ENOG4105CXN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CXN epestfind swissprot:DCOR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DCOR_ECOLI garnier swissprot:DCOR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DCOR_ECOLI helixturnhelix swissprot:DCOR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DCOR_ECOLI hmoment swissprot:DCOR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DCOR_ECOLI iep swissprot:DCOR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DCOR_ECOLI inforesidue swissprot:DCOR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DCOR_ECOLI octanol swissprot:DCOR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DCOR_ECOLI pepcoil swissprot:DCOR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DCOR_ECOLI pepdigest swissprot:DCOR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DCOR_ECOLI pepinfo swissprot:DCOR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DCOR_ECOLI pepnet swissprot:DCOR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DCOR_ECOLI pepstats swissprot:DCOR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DCOR_ECOLI pepwheel swissprot:DCOR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DCOR_ECOLI pepwindow swissprot:DCOR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DCOR_ECOLI sigcleave swissprot:DCOR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DCOR_ECOLI ## Database ID URL or Descriptions # BioGrid 4259321 106 # EcoGene EG11366 rob # FUNCTION ROB_ECOLI Binds to the right arm of the replication origin oriC of the chromosome. Rob binding may influence the formation of the nucleoprotein structure, required for oriC function in the initiation of replication. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000987 core promoter proximal region sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0043565 sequence-specific DNA binding; IDA:EcoliWiki. # GO_process GO:0006355 regulation of transcription, DNA-templated; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # Gene3D 1.10.10.60 -; 2. # Gene3D 3.20.80.10 -; 1. # IntAct P0ACI0 6 # InterPro IPR009057 Homeodomain-like # InterPro IPR010499 AraC_E-bd # InterPro IPR011256 Reg_factor_effector_dom # InterPro IPR018060 HTH_AraC # InterPro IPR018062 HTH_AraC-typ_CS # InterPro IPR020449 Tscrpt_reg_HTH_AraC-type # InterPro IPR029442 GyrI-like # KEGG_Brite ko03036 Chromosome # Organism ROB_ECOLI Escherichia coli (strain K12) # PATRIC 32124410 VBIEscCol129921_4545 # PDB 1D5Y X-ray; 2.70 A; A/B/C/D=3-289 # PIR JU0158 JU0158 # PRINTS PR00032 HTHARAC # PROSITE PS00041 HTH_ARAC_FAMILY_1 # PROSITE PS01124 HTH_ARAC_FAMILY_2 # Pfam PF06445 GyrI-like # Pfam PF12833 HTH_18 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ROB_ECOLI Right origin-binding protein # RefSeq NP_418813 NC_000913.3 # RefSeq WP_000371666 NZ_LN832404.1 # SIMILARITY Contains 1 HTH araC/xylS-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00593}. # SMART SM00342 HTH_ARAC # SMART SM00871 AraC_E_bind # SUPFAM SSF46689 SSF46689; 2 # SUPFAM SSF55136 SSF55136 # eggNOG COG2207 LUCA # eggNOG ENOG4105UEI Bacteria BLAST swissprot:ROB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ROB_ECOLI BioCyc ECOL316407:JW4359-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4359-MONOMER BioCyc EcoCyc:PD04418 http://biocyc.org/getid?id=EcoCyc:PD04418 COG COG2207 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2207 DIP DIP-47868N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47868N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M97495 http://www.ebi.ac.uk/ena/data/view/M97495 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB1340 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1340 EcoGene EG11366 http://www.ecogene.org/geneInfo.php?eg_id=EG11366 EnsemblBacteria AAC77349 http://www.ensemblgenomes.org/id/AAC77349 EnsemblBacteria AAC77349 http://www.ensemblgenomes.org/id/AAC77349 EnsemblBacteria BAE78385 http://www.ensemblgenomes.org/id/BAE78385 EnsemblBacteria BAE78385 http://www.ensemblgenomes.org/id/BAE78385 EnsemblBacteria BAE78385 http://www.ensemblgenomes.org/id/BAE78385 EnsemblBacteria b4396 http://www.ensemblgenomes.org/id/b4396 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000987 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000987 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 Gene3D 3.20.80.10 http://www.cathdb.info/version/latest/superfamily/3.20.80.10 GeneID 948916 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948916 HOGENOM HOG000127886 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000127886&db=HOGENOM6 InParanoid P0ACI0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACI0 IntAct P0ACI0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACI0* InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR010499 http://www.ebi.ac.uk/interpro/entry/IPR010499 InterPro IPR011256 http://www.ebi.ac.uk/interpro/entry/IPR011256 InterPro IPR018060 http://www.ebi.ac.uk/interpro/entry/IPR018060 InterPro IPR018062 http://www.ebi.ac.uk/interpro/entry/IPR018062 InterPro IPR020449 http://www.ebi.ac.uk/interpro/entry/IPR020449 InterPro IPR029442 http://www.ebi.ac.uk/interpro/entry/IPR029442 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene ecj:JW4359 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4359 KEGG_Gene eco:b4396 http://www.genome.jp/dbget-bin/www_bget?eco:b4396 KEGG_Orthology KO:K05804 http://www.genome.jp/dbget-bin/www_bget?KO:K05804 MINT MINT-1246646 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1246646 OMA WCATGIC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WCATGIC PDB 1D5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/1D5Y PDBsum 1D5Y http://www.ebi.ac.uk/pdbsum/1D5Y PRINTS PR00032 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00032 PROSITE PS00041 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00041 PROSITE PS01124 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01124 PSORT swissprot:ROB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ROB_ECOLI PSORT-B swissprot:ROB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ROB_ECOLI PSORT2 swissprot:ROB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ROB_ECOLI Pfam PF06445 http://pfam.xfam.org/family/PF06445 Pfam PF12833 http://pfam.xfam.org/family/PF12833 Phobius swissprot:ROB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ROB_ECOLI PhylomeDB P0ACI0 http://phylomedb.org/?seqid=P0ACI0 ProteinModelPortal P0ACI0 http://www.proteinmodelportal.org/query/uniprot/P0ACI0 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8449900 http://www.ncbi.nlm.nih.gov/pubmed/8449900 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418813 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418813 RefSeq WP_000371666 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000371666 SMART SM00342 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00342 SMART SM00871 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00871 SMR P0ACI0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACI0 STRING 511145.b4396 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4396&targetmode=cogs STRING COG2207 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2207&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF55136 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55136 UniProtKB ROB_ECOLI http://www.uniprot.org/uniprot/ROB_ECOLI UniProtKB-AC P0ACI0 http://www.uniprot.org/uniprot/P0ACI0 charge swissprot:ROB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ROB_ECOLI eggNOG COG2207 http://eggnogapi.embl.de/nog_data/html/tree/COG2207 eggNOG ENOG4105UEI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105UEI epestfind swissprot:ROB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ROB_ECOLI garnier swissprot:ROB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ROB_ECOLI helixturnhelix swissprot:ROB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ROB_ECOLI hmoment swissprot:ROB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ROB_ECOLI iep swissprot:ROB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ROB_ECOLI inforesidue swissprot:ROB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ROB_ECOLI octanol swissprot:ROB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ROB_ECOLI pepcoil swissprot:ROB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ROB_ECOLI pepdigest swissprot:ROB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ROB_ECOLI pepinfo swissprot:ROB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ROB_ECOLI pepnet swissprot:ROB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ROB_ECOLI pepstats swissprot:ROB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ROB_ECOLI pepwheel swissprot:ROB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ROB_ECOLI pepwindow swissprot:ROB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ROB_ECOLI sigcleave swissprot:ROB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ROB_ECOLI ## Database ID URL or Descriptions # AltName Bacteriophage Q beta RNA-directed RNA polymerase subunit I {ECO:0000303|PubMed 816798} # BioGrid 4263060 145 # DISRUPTION PHENOTYPE Essential, it cannot be deleted. Upon depletion cell growth and total protein synthesis become linear. {ECO:0000269|PubMed 9677288}. # DOMAIN RS1_ECOLI The 6 S1 motif domains are not equivalent; the first 2 no longer bind rRNA but instead are involved in protein-ribosome and protein-protein interactions. Binds to the 30S ribosomal subunit via its N-terminal fragment (190 residues, the first 2 S1 motifs) and allows translation by S1-free ribosomes (PubMed 7003157, PubMed 15340139). The same fragment represses its own translation (PubMed 2120211). The first 3 S1 motifs do however bind to mRNA pseudoknots in the 5'-UTR of at least 1 mRNA (rpsO); deletion of S1 motifs 1-3 but not motifs 4-6 is not viable, although a deletion of motifs 4-6 grows slowly and is cold-sensitive (PubMed 24339747). In case of infection by bacteriophage Qbeta the same N-terminal fragment is necessary and sufficient to form the Qbeta virus RNA-dependent RNA polymerase, although in vitro (-) strand RNA synthesis from the (+) strand genomic RNA also requires the third S1 motif (residues 1-273) (PubMed 6358207, PubMed 25122749). The third S1 motif is required to bind mRNA, tmRNA and viral M-site RNA but requires cooperation with other S1 motifs (PubMed 15340139, PubMed 25122749). {ECO 0000269|PubMed 15340139, ECO 0000269|PubMed 2120211, ECO 0000269|PubMed 24339747, ECO 0000269|PubMed 25122749, ECO 0000269|PubMed 6358207, ECO 0000269|PubMed 7003157}. # EcoGene EG10900 rpsA # FUNCTION RS1_ECOLI In case of infection by bacteriophage Qbeta, part of the viral RNA-dependent RNA polymerase complex; this subunit is required for RNA replication initiation activity during synthesis of (-) strand RNA from the (+) strand genomic RNA but not for (+) strand synthesis from the (-) strand (PubMed 6358207, PubMed 25122749). Binds an approximately 70 mucleotide RNA internal to the viral replicase gene (the M-site) (PubMed 25122749). Others have reported it is not involved in RNA replication initiation but rather in termination of RNA synthesis and is required for termination whether it is the (+) or (-) strand that is being synthesized (PubMed 23653193). {ECO 0000269|PubMed 23653193, ECO 0000269|PubMed 25122749, ECO 0000269|PubMed 6358207, ECO 0000269|PubMed 816798}. # FUNCTION RS1_ECOLI In case of infection by bacteriophage T4, plays a significant role in substrate choice by viral endoribonuclease RegB. {ECO 0000269|PubMed 17130171}. # FUNCTION RS1_ECOLI It is not clear if it plays a role in trans-translation (a process which rescues stalled ribosomes). Evidence for its role; binds to tmRNA with very high affinity, is required for binding of tmRNA to 30S subunit (PubMed 11101533, PubMed 15340139). Thought to play a role only in translation of the tmRNA in vitro (PubMed 17392345). Evidence against its role; overexpression of whole protein or various S1 fragments inhibits translation, they have no effect on trans-translation, and an in vitro system with S1-less ribosomes performs trans-translation (PubMed 15340139, PubMed 17376482). In trans-translation Ala- aminoacylated transfer-messenger RNA (tmRNA, product of the ssrA gene; the 2 termini fold to resemble tRNA(Ala) while it encodes a short internal open reading frame (the tag peptide)) acts like a tRNA, entering the A-site of the ribosome and displacing the stalled mRNA (which is subsequently degraded). The ribosome then switches to translate the ORF on the tmRNA, the nascent peptide is terminated with the "tag peptide" encoded by the tmRNA and thus targeted for degradation. {ECO 0000269|PubMed 11101533, ECO 0000269|PubMed 15340139, ECO 0000269|PubMed 17376482, ECO 0000269|PubMed 17392345}. # FUNCTION RS1_ECOLI Required for translation of most natural mRNAs except for leaderless mRNA (PubMed 9677288, PubMed 7003157, PubMed 12068815, PubMed 17376482, PubMed 24339747). Binds mRNA upstream of the Shine-Dalgarno (SD) sequence and helps it bind to the 30S ribosomal subunit; acts as an RNA chaperone to unfold structured mRNA on the ribosome but is not essential for mRNAs with strong SDs and little 5'-UTR structure, thus it may help fine-tune which mRNAs that are translated (PubMed 24339747). Unwinds dsRNA by binding to transiently formed ssRNA regions; binds about 10 nucleotides (PubMed 22908248). Has a preference for polypyrimidine tracts (PubMed 778845). Negatively autoregulates its own translation (PubMed 2120211). {ECO 0000269|PubMed 12068815, ECO 0000269|PubMed 15340139, ECO 0000269|PubMed 1712292, ECO 0000269|PubMed 17376482, ECO 0000269|PubMed 2120211, ECO 0000269|PubMed 22908248, ECO 0000269|PubMed 24339747, ECO 0000269|PubMed 7003157, ECO 0000269|PubMed 778845, ECO 0000269|PubMed 9677288}. # GO_component GO:0005737 cytoplasm; IDA:UniProtKB. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_component GO:0022627 cytosolic small ribosomal subunit; IDA:EcoCyc. # GO_function GO:0003723 RNA binding; IDA:EcoCyc. # GO_function GO:0003729 mRNA binding; IDA:EcoCyc. # GO_function GO:0003735 structural constituent of ribosome; IDA:EcoCyc. # GO_process GO:0006412 translation; IMP:EcoCyc. # GO_process GO:2000766 negative regulation of cytoplasmic translation; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0003729 mRNA binding # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_process GO:0006412 translation # GOslim_process GO:0008150 biological_process # INDUCTION Represses its own translation via the N-terminus (at protein level). {ECO:0000269|PubMed 2120211}. # INTERACTION RS1_ECOLI Self; NbExp=2; IntAct=EBI-546520, EBI-546520; # IntAct P0AG67 80 # InterPro IPR000110 Ribosomal_S1 # InterPro IPR003029 S1_domain # InterPro IPR012340 NA-bd_OB-fold # InterPro IPR022967 S1_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # Organism RS1_ECOLI Escherichia coli (strain K12) # PATRIC 32117035 VBIEscCol129921_0942 # PDB 2BH8 X-ray; 1.90 A; A/B=364-398 # PDB 2KHI NMR; -; A=267-361 # PDB 2KHJ NMR; -; A=441-528 # PDB 4Q7J X-ray; 2.90 A; D/H=1-273 # PDB 4R71 X-ray; 3.21 A; E/F=2-171 # PIR F64830 R3EC1 # PIRSF PIRSF002111 RpsA # PRINTS PR00681 RIBOSOMALS1 # PROSITE PS50126 S1; 6 # PTM RS1_ECOLI Phosphorylated; probably on a serine. {ECO 0000269|PubMed 7783627}. # Pfam PF00575 S1; 6 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RS1_ECOLI 30S ribosomal protein S1 # RefSeq NP_415431 NC_000913.3 # RefSeq WP_000140327 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein S1P family. {ECO 0000305}. # SIMILARITY Contains 6 S1 motif domains. {ECO:0000255|PROSITE- ProRule PRU00180}. # SMART SM00316 S1; 6 # SUBCELLULAR LOCATION RS1_ECOLI Cytoplasm {ECO 0000269|PubMed 342903}. # SUBUNIT RS1_ECOLI Part of the 30S ribosomal subunit; the largest protein subunit, it is loosely associated and rarely found in ribosomal crystal structures (PubMed 7041110, PubMed 7003157, PubMed 778845, PubMed 342903). Does not bind rRNA. Probably requires ribosomal protein S2 to associate with the 30S subunit (PubMed 12068815). Binds in the junction of the head, platform and main body of the 30S subunit; the N-terminus penetrates the 30S subunit while the C-terminus faces ribosomal protein S2 (PubMed 11593008). Nascent polypeptide chains cross-link this protein in situ (PubMed 9716382). Can be cross-linked to mRNA in the ribosome (PubMed 1712292). In case of infection by bacteriophage Qbeta, part of the viral RNA-dependent RNA polymerase complex, the other subunits are the viral replicase catalytic subunit (AC P14647), host EF-Tu and EF-Ts (PubMed 816798, PubMed 6358207, PubMed 25122749). {ECO 0000269|PubMed 11593008, ECO 0000269|PubMed 12068815, ECO 0000269|PubMed 1712292, ECO 0000269|PubMed 25122749, ECO 0000269|PubMed 342903, ECO 0000269|PubMed 6358207, ECO 0000269|PubMed 7003157, ECO 0000269|PubMed 7041110, ECO 0000269|PubMed 778845, ECO 0000269|PubMed 816798, ECO 0000269|PubMed 9716382}. # SUPFAM SSF50249 SSF50249; 6 # TIGRFAMs TIGR00717 rpsA # eggNOG COG0539 LUCA # eggNOG ENOG4105CAV Bacteria BLAST swissprot:RS1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RS1_ECOLI BioCyc ECOL316407:JW0894-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0894-MONOMER BioCyc EcoCyc:EG10900-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10900-MONOMER BioCyc MetaCyc:EG10900-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10900-MONOMER COG COG0539 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0539 DIP DIP-35884N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35884N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1998.1909 http://dx.doi.org/10.1006/jmbi.1998.1909 DOI 10.1007/BF00334105 http://dx.doi.org/10.1007/BF00334105 DOI 10.1007/BF00455113 http://dx.doi.org/10.1007/BF00455113 DOI 10.1016/0022-2836(80)90253-3 http://dx.doi.org/10.1016/0022-2836(80)90253-3 DOI 10.1016/0022-2836(85)90206-2 http://dx.doi.org/10.1016/0022-2836(85)90206-2 DOI 10.1016/j.biochi.2012.02.010 http://dx.doi.org/10.1016/j.biochi.2012.02.010 DOI 10.1016/j.jmb.2007.02.068 http://dx.doi.org/10.1016/j.jmb.2007.02.068 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/ncomms2807 http://dx.doi.org/10.1038/ncomms2807 DOI 10.1046/j.1365-2958.2002.02971.x http://dx.doi.org/10.1046/j.1365-2958.2002.02971.x DOI 10.1046/j.1432-1327.1998.2550409.x http://dx.doi.org/10.1046/j.1432-1327.1998.2550409.x DOI 10.1073/pnas.0405521101 http://dx.doi.org/10.1073/pnas.0405521101 DOI 10.1073/pnas.1208950109 http://dx.doi.org/10.1073/pnas.1208950109 DOI 10.1073/pnas.211266898 http://dx.doi.org/10.1073/pnas.211266898 DOI 10.1073/pnas.73.6.1824 http://dx.doi.org/10.1073/pnas.73.6.1824 DOI 10.1073/pnas.79.4.1008 http://dx.doi.org/10.1073/pnas.79.4.1008 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/emboj/19.23.6612 http://dx.doi.org/10.1093/emboj/19.23.6612 DOI 10.1093/nar/10.6.1857 http://dx.doi.org/10.1093/nar/10.6.1857 DOI 10.1093/nar/gkl911 http://dx.doi.org/10.1093/nar/gkl911 DOI 10.1093/nar/gkm100 http://dx.doi.org/10.1093/nar/gkm100 DOI 10.1093/nar/gkp547 http://dx.doi.org/10.1093/nar/gkp547 DOI 10.1093/nar/gku745 http://dx.doi.org/10.1093/nar/gku745 DOI 10.1111/j.1365-2958.1995.tb02270.x http://dx.doi.org/10.1111/j.1365-2958.1995.tb02270.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pbio.1001731 http://dx.doi.org/10.1371/journal.pbio.1001731 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00342 http://www.ebi.ac.uk/ena/data/view/V00342 EMBL V00352 http://www.ebi.ac.uk/ena/data/view/V00352 EMBL X00785 http://www.ebi.ac.uk/ena/data/view/X00785 EMBL X04864 http://www.ebi.ac.uk/ena/data/view/X04864 EchoBASE EB0893 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0893 EcoGene EG10900 http://www.ecogene.org/geneInfo.php?eg_id=EG10900 EnsemblBacteria AAC73997 http://www.ensemblgenomes.org/id/AAC73997 EnsemblBacteria AAC73997 http://www.ensemblgenomes.org/id/AAC73997 EnsemblBacteria BAA35655 http://www.ensemblgenomes.org/id/BAA35655 EnsemblBacteria BAA35655 http://www.ensemblgenomes.org/id/BAA35655 EnsemblBacteria BAA35655 http://www.ensemblgenomes.org/id/BAA35655 EnsemblBacteria b0911 http://www.ensemblgenomes.org/id/b0911 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0022627 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022627 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0003729 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003729 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GO_process GO:2000766 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000766 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0003729 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003729 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 945536 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945536 HOGENOM HOG000044052 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000044052&db=HOGENOM6 InParanoid P0AG67 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AG67 IntAct P0AG67 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AG67* InterPro IPR000110 http://www.ebi.ac.uk/interpro/entry/IPR000110 InterPro IPR003029 http://www.ebi.ac.uk/interpro/entry/IPR003029 InterPro IPR012340 http://www.ebi.ac.uk/interpro/entry/IPR012340 InterPro IPR022967 http://www.ebi.ac.uk/interpro/entry/IPR022967 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW0894 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0894 KEGG_Gene eco:b0911 http://www.genome.jp/dbget-bin/www_bget?eco:b0911 KEGG_Orthology KO:K02945 http://www.genome.jp/dbget-bin/www_bget?KO:K02945 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 MINT MINT-1315122 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1315122 OMA ISWDKNV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ISWDKNV PDB 2BH8 http://www.ebi.ac.uk/pdbe-srv/view/entry/2BH8 PDB 2KHI http://www.ebi.ac.uk/pdbe-srv/view/entry/2KHI PDB 2KHJ http://www.ebi.ac.uk/pdbe-srv/view/entry/2KHJ PDB 4Q7J http://www.ebi.ac.uk/pdbe-srv/view/entry/4Q7J PDB 4R71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4R71 PDBsum 2BH8 http://www.ebi.ac.uk/pdbsum/2BH8 PDBsum 2KHI http://www.ebi.ac.uk/pdbsum/2KHI PDBsum 2KHJ http://www.ebi.ac.uk/pdbsum/2KHJ PDBsum 4Q7J http://www.ebi.ac.uk/pdbsum/4Q7J PDBsum 4R71 http://www.ebi.ac.uk/pdbsum/4R71 PRINTS PR00681 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00681 PROSITE PS50126 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50126 PSORT swissprot:RS1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RS1_ECOLI PSORT-B swissprot:RS1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RS1_ECOLI PSORT2 swissprot:RS1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RS1_ECOLI Pfam PF00575 http://pfam.xfam.org/family/PF00575 Phobius swissprot:RS1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RS1_ECOLI PhylomeDB P0AG67 http://phylomedb.org/?seqid=P0AG67 ProteinModelPortal P0AG67 http://www.proteinmodelportal.org/query/uniprot/P0AG67 PubMed 11101533 http://www.ncbi.nlm.nih.gov/pubmed/11101533 PubMed 11593008 http://www.ncbi.nlm.nih.gov/pubmed/11593008 PubMed 12068815 http://www.ncbi.nlm.nih.gov/pubmed/12068815 PubMed 15340139 http://www.ncbi.nlm.nih.gov/pubmed/15340139 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1712292 http://www.ncbi.nlm.nih.gov/pubmed/1712292 PubMed 17130171 http://www.ncbi.nlm.nih.gov/pubmed/17130171 PubMed 17376482 http://www.ncbi.nlm.nih.gov/pubmed/17376482 PubMed 17392345 http://www.ncbi.nlm.nih.gov/pubmed/17392345 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 19605565 http://www.ncbi.nlm.nih.gov/pubmed/19605565 PubMed 2120211 http://www.ncbi.nlm.nih.gov/pubmed/2120211 PubMed 22370051 http://www.ncbi.nlm.nih.gov/pubmed/22370051 PubMed 22908248 http://www.ncbi.nlm.nih.gov/pubmed/22908248 PubMed 23653193 http://www.ncbi.nlm.nih.gov/pubmed/23653193 PubMed 24339747 http://www.ncbi.nlm.nih.gov/pubmed/24339747 PubMed 25122749 http://www.ncbi.nlm.nih.gov/pubmed/25122749 PubMed 3159903 http://www.ncbi.nlm.nih.gov/pubmed/3159903 PubMed 342903 http://www.ncbi.nlm.nih.gov/pubmed/342903 PubMed 6281725 http://www.ncbi.nlm.nih.gov/pubmed/6281725 PubMed 6358207 http://www.ncbi.nlm.nih.gov/pubmed/6358207 PubMed 6384724 http://www.ncbi.nlm.nih.gov/pubmed/6384724 PubMed 7003157 http://www.ncbi.nlm.nih.gov/pubmed/7003157 PubMed 7041110 http://www.ncbi.nlm.nih.gov/pubmed/7041110 PubMed 7783627 http://www.ncbi.nlm.nih.gov/pubmed/7783627 PubMed 778845 http://www.ncbi.nlm.nih.gov/pubmed/778845 PubMed 816798 http://www.ncbi.nlm.nih.gov/pubmed/816798 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9677288 http://www.ncbi.nlm.nih.gov/pubmed/9677288 PubMed 9716382 http://www.ncbi.nlm.nih.gov/pubmed/9716382 RefSeq NP_415431 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415431 RefSeq WP_000140327 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000140327 SMART SM00316 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00316 SMR P0AG67 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AG67 STRING 511145.b0911 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0911&targetmode=cogs STRING COG0539 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0539&targetmode=cogs SUPFAM SSF50249 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50249 SWISS-2DPAGE P0AG67 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AG67 TIGRFAMs TIGR00717 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00717 UniProtKB RS1_ECOLI http://www.uniprot.org/uniprot/RS1_ECOLI UniProtKB-AC P0AG67 http://www.uniprot.org/uniprot/P0AG67 charge swissprot:RS1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RS1_ECOLI eggNOG COG0539 http://eggnogapi.embl.de/nog_data/html/tree/COG0539 eggNOG ENOG4105CAV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CAV epestfind swissprot:RS1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RS1_ECOLI garnier swissprot:RS1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RS1_ECOLI helixturnhelix swissprot:RS1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RS1_ECOLI hmoment swissprot:RS1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RS1_ECOLI iep swissprot:RS1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RS1_ECOLI inforesidue swissprot:RS1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RS1_ECOLI octanol swissprot:RS1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RS1_ECOLI pepcoil swissprot:RS1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RS1_ECOLI pepdigest swissprot:RS1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RS1_ECOLI pepinfo swissprot:RS1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RS1_ECOLI pepnet swissprot:RS1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RS1_ECOLI pepstats swissprot:RS1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RS1_ECOLI pepwheel swissprot:RS1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RS1_ECOLI pepwindow swissprot:RS1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RS1_ECOLI sigcleave swissprot:RS1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RS1_ECOLI ## Database ID URL or Descriptions # ALTERNATIVE PRODUCTS NPD_ECOLI Event=Alternative promoter usage; Named isoforms=2; Name=CobB-Long {ECO 0000250|UniProtKB P0A2F2}; IsoId=P75960-1; Sequence=Displayed; Name=CobB-Short {ECO 0000250|UniProtKB P0A2F2}; IsoId=P75960-2; Sequence=VSP_058458; # AltName Regulatory protein SIR2 homolog {ECO:0000255|HAMAP-Rule MF_01121} # BIOPHYSICOCHEMICAL PROPERTIES NPD_ECOLI Kinetic parameters KM=15.1 uM for a synthetic histone H3K9 acetyllysine peptide {ECO 0000269|PubMed 24176774}; KM=86 uM for a synthetic histone H3K9 succinyllysine peptide {ECO 0000269|PubMed 24176774}; Note=kcat is 0.135 sec(-1) for acetyllysine peptide. kcat is 0.242 sec(-1) for succinyllysine peptide.; # BioGrid 4260089 13 # CATALYTIC ACTIVITY NAD(+) + a succinylprotein = nicotinamide + O- succinyl-ADP-ribose + a protein. {ECO:0000255|HAMAP- Rule MF_01121}. # CATALYTIC ACTIVITY NAD(+) + an acetylprotein = nicotinamide + O- acetyl-ADP-ribose + a protein. {ECO:0000255|HAMAP-Rule MF_01121}. # CAUTION In contrast to human SIRT5, which has only weak deacetylation activity, CobB shows comparable lysine deacetylation and lysine desuccinylation activities. {ECO:0000305|PubMed 24176774}. # CAUTION PubMed:10381378 has reported that this protein has a weak ADP-ribosyltransferase activity, but that is probably not its primary activity in vivo. {ECO 0000305}. # CAUTION Was originally thought to be involved in cobalamin biosynthesis. {ECO 0000305}. # CDD cd01412 SIRT5_Af1_CobB # COFACTOR NPD_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000255|HAMAP-Rule MF_01121, ECO 0000269|PubMed 15019790}; Note=Binds 1 zinc ion per subunit. {ECO 0000255|HAMAP- Rule MF_01121, ECO 0000269|PubMed 15019790}; # DOMAIN NPD_ECOLI 2 residues (Tyr-92 and Arg-95) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity. {ECO 0000255|HAMAP-Rule MF_01121, ECO 0000269|PubMed 24176774}. # EcoGene EG13443 cobB # FUNCTION NPD_ECOLI NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Activates the enzyme acetyl-CoA synthetase by deacetylating 'Lys-609' in the inactive, acetylated form of the enzyme. May also modulate the activity of other propionyl-adenosine monophosphate (AMP)-forming enzymes. {ECO 0000255|HAMAP-Rule MF_01121, ECO 0000269|PubMed 10811920, ECO 0000269|PubMed 15019790, ECO 0000269|PubMed 24176774}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0008270 zinc ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0034979 NAD-dependent protein deacetylase activity; IDA:EcoCyc. # GO_function GO:0036054 protein-malonyllysine demalonylase activity; IEA:InterPro. # GO_function GO:0036055 protein-succinyllysine desuccinylase activity; IDA:EcoCyc. # GO_function GO:0070403 NAD+ binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006935 chemotaxis; IMP:EcoCyc. # GO_process GO:0034983 peptidyl-lysine deacetylation; IDA:EcoCyc. # GO_process GO:0036049 peptidyl-lysine desuccinylation; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0040011 locomotion # Gene3D 3.30.1600.10 -; 2. # Gene3D 3.40.50.1220 -; 3. # HAMAP MF_01121 Sirtuin_ClassIII # INTERACTION NPD_ECOLI P75869 sxy; NbExp=8; IntAct=EBI-544459, EBI-544452; # IntAct P75960 18 # InterPro IPR003000 Sirtuin # InterPro IPR026590 Ssirtuin_cat_dom # InterPro IPR026591 Sirtuin_cat_small_dom # InterPro IPR027546 Sirtuin_class_III # InterPro IPR029035 DHS-like_NAD/FAD-binding_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00520 Amino sugar and nucleotide sugar metabolism # Organism NPD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11085 PTHR11085 # PATRIC 32117487 VBIEscCol129921_1166 # PDB 1S5P X-ray; 1.96 A; A=40-274 # PIR E64856 E64856 # PROSITE PS50305 SIRTUIN # Pfam PF02146 SIR2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NAD-dependent protein deacylase {ECO:0000255|HAMAP-Rule MF_01121} # RefSeq NP_415638 NC_000913.3 # RefSeq WP_000952737 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAC74204.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the sirtuin family. Class III subfamily. {ECO:0000255|HAMAP-Rule MF_01121}. # SIMILARITY Contains 1 deacetylase sirtuin-type domain. {ECO:0000255|HAMAP-Rule MF_01121}. # SUBCELLULAR LOCATION NPD_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_01121}. # SUBUNIT Forms a 1:1 complex with acetyl-CoA synthetase (Acs). {ECO 0000269|PubMed:15019790}. # SUPFAM SSF52467 SSF52467 # eggNOG COG0846 LUCA # eggNOG ENOG4105NDF Bacteria BLAST swissprot:NPD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NPD_ECOLI BioCyc ECOL316407:JW1106-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1106-MONOMER BioCyc EcoCyc:G6577-MONOMER http://biocyc.org/getid?id=EcoCyc:G6577-MONOMER BioCyc MetaCyc:G6577-MONOMER http://biocyc.org/getid?id=MetaCyc:G6577-MONOMER COG COG0846 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0846 DIP DIP-9301N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9301N DOI 10.1002/pmic.200600599 http://dx.doi.org/10.1002/pmic.200600599 DOI 10.1006/bbrc.1999.0897 http://dx.doi.org/10.1006/bbrc.1999.0897 DOI 10.1016/j.jmb.2004.01.060 http://dx.doi.org/10.1016/j.jmb.2004.01.060 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.110148297 http://dx.doi.org/10.1073/pnas.110148297 DOI 10.1074/mcp.M113.031567 http://dx.doi.org/10.1074/mcp.M113.031567 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.5.1.- {ECO:0000255|HAMAP-Rule:MF_01121} http://www.genome.jp/dbget-bin/www_bget?EC:3.5.1.- {ECO:0000255|HAMAP-Rule:MF_01121} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.5.1.- {ECO:0000255|HAMAP-Rule:MF_01121} http://enzyme.expasy.org/EC/3.5.1.- {ECO:0000255|HAMAP-Rule:MF_01121} EchoBASE EB3217 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3217 EcoGene EG13443 http://www.ecogene.org/geneInfo.php?eg_id=EG13443 EnsemblBacteria AAC74204 http://www.ensemblgenomes.org/id/AAC74204 EnsemblBacteria AAC74204 http://www.ensemblgenomes.org/id/AAC74204 EnsemblBacteria BAA35940 http://www.ensemblgenomes.org/id/BAA35940 EnsemblBacteria BAA35940 http://www.ensemblgenomes.org/id/BAA35940 EnsemblBacteria BAA35940 http://www.ensemblgenomes.org/id/BAA35940 EnsemblBacteria b1120 http://www.ensemblgenomes.org/id/b1120 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0034979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034979 GO_function GO:0036054 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036054 GO_function GO:0036055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036055 GO_function GO:0070403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070403 GO_process GO:0006935 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006935 GO_process GO:0034983 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034983 GO_process GO:0036049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036049 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0040011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011 Gene3D 3.30.1600.10 http://www.cathdb.info/version/latest/superfamily/3.30.1600.10 Gene3D 3.40.50.1220 http://www.cathdb.info/version/latest/superfamily/3.40.50.1220 GeneID 945687 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945687 HAMAP MF_01121 http://hamap.expasy.org/unirule/MF_01121 HOGENOM HOG000085950 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000085950&db=HOGENOM6 InParanoid P75960 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75960 IntAct P75960 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75960* IntEnz 3.5.1.- {ECO:0000255|HAMAP-Rule:MF_01121} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.1.- {ECO:0000255|HAMAP-Rule:MF_01121} InterPro IPR003000 http://www.ebi.ac.uk/interpro/entry/IPR003000 InterPro IPR026590 http://www.ebi.ac.uk/interpro/entry/IPR026590 InterPro IPR026591 http://www.ebi.ac.uk/interpro/entry/IPR026591 InterPro IPR027546 http://www.ebi.ac.uk/interpro/entry/IPR027546 InterPro IPR029035 http://www.ebi.ac.uk/interpro/entry/IPR029035 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1106 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1106 KEGG_Gene eco:b1120 http://www.genome.jp/dbget-bin/www_bget?eco:b1120 KEGG_Orthology KO:K12410 http://www.genome.jp/dbget-bin/www_bget?KO:K12410 KEGG_Pathway ko00520 http://www.genome.jp/kegg-bin/show_pathway?ko00520 KEGG_Reaction rn:R00765 http://www.genome.jp/dbget-bin/www_bget?rn:R00765 MINT MINT-1290133 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1290133 PANTHER PTHR11085 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11085 PDB 1S5P http://www.ebi.ac.uk/pdbe-srv/view/entry/1S5P PDBsum 1S5P http://www.ebi.ac.uk/pdbsum/1S5P PROSITE PS50305 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50305 PSORT swissprot:NPD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NPD_ECOLI PSORT-B swissprot:NPD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NPD_ECOLI PSORT2 swissprot:NPD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NPD_ECOLI Pfam PF02146 http://pfam.xfam.org/family/PF02146 Phobius swissprot:NPD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NPD_ECOLI PhylomeDB P75960 http://phylomedb.org/?seqid=P75960 ProteinModelPortal P75960 http://www.proteinmodelportal.org/query/uniprot/P75960 PubMed 10381378 http://www.ncbi.nlm.nih.gov/pubmed/10381378 PubMed 10811920 http://www.ncbi.nlm.nih.gov/pubmed/10811920 PubMed 15019790 http://www.ncbi.nlm.nih.gov/pubmed/15019790 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17366475 http://www.ncbi.nlm.nih.gov/pubmed/17366475 PubMed 24176774 http://www.ncbi.nlm.nih.gov/pubmed/24176774 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415638 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415638 RefSeq WP_000952737 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000952737 SMR P75960 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75960 STRING 511145.b1120 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1120&targetmode=cogs STRING COG0846 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0846&targetmode=cogs SUPFAM SSF52467 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52467 UniProtKB NPD_ECOLI http://www.uniprot.org/uniprot/NPD_ECOLI UniProtKB-AC P75960 http://www.uniprot.org/uniprot/P75960 charge swissprot:NPD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NPD_ECOLI eggNOG COG0846 http://eggnogapi.embl.de/nog_data/html/tree/COG0846 eggNOG ENOG4105NDF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105NDF epestfind swissprot:NPD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NPD_ECOLI garnier swissprot:NPD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NPD_ECOLI helixturnhelix swissprot:NPD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NPD_ECOLI hmoment swissprot:NPD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NPD_ECOLI iep swissprot:NPD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NPD_ECOLI inforesidue swissprot:NPD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NPD_ECOLI octanol swissprot:NPD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NPD_ECOLI pepcoil swissprot:NPD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NPD_ECOLI pepdigest swissprot:NPD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NPD_ECOLI pepinfo swissprot:NPD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NPD_ECOLI pepnet swissprot:NPD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NPD_ECOLI pepstats swissprot:NPD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NPD_ECOLI pepwheel swissprot:NPD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NPD_ECOLI pepwindow swissprot:NPD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NPD_ECOLI sigcleave swissprot:NPD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NPD_ECOLI ## Database ID URL or Descriptions # AltName Vitamin B12-transporting ATPase {ECO:0000255|HAMAP-Rule MF_01005} # BRENDA 3.6.3.33 2026 # BioGrid 4260301 184 # CATALYTIC ACTIVITY ATP + H(2)O + vitamin B12(Out) = ADP + phosphate + vitamin B12(In). {ECO:0000255|HAMAP-Rule MF_01005}. # EcoGene EG10128 btuD # FUNCTION BTUD_ECOLI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system. {ECO 0000255|HAMAP-Rule MF_01005}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0019898 extrinsic component of membrane; IDA:EcoliWiki. # GO_component GO:0031234 extrinsic component of cytoplasmic side of plasma membrane; IDA:EcoCyc. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0015420 cobalamin-transporting ATPase activity; IDA:EcoCyc. # GO_process GO:0015889 cobalamin transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # Gene3D 3.40.50.300 -; 1. # HAMAP MF_01005 BtuD # INTERACTION BTUD_ECOLI P06609 btuC; NbExp=3; IntAct=EBI-1033420, EBI-1033427; # IntAct P06611 9 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR017871 ABC_transporter_CS # InterPro IPR023693 ABC_transptr_BtuD # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00241 Vitamin B12 transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism BTUD_ECOLI Escherichia coli (strain K12) # PATRIC 32118724 VBIEscCol129921_1780 # PDB 1L7V X-ray; 3.20 A; C/D=1-249 # PDB 2QI9 X-ray; 2.60 A; C/D=1-249 # PDB 4DBL X-ray; 3.49 A; C/D/H/I=1-249 # PDB 4FI3 X-ray; 3.47 A; C/D=1-249 # PDB 4R9U X-ray; 2.78 A; C/D=1-249 # PIR C24498 QRECBD # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # Pfam PF00005 ABC_tran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Vitamin B12 import ATP-binding protein BtuD {ECO:0000255|HAMAP-Rule MF_01005} # RefSeq NP_416224 NC_000913.3 # RefSeq WP_000029474 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. Vitamin B12 importer (TC 3.A.1.13.1) family. {ECO:0000255|HAMAP- Rule MF_01005}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|HAMAP- Rule MF_01005}. # SMART SM00382 AAA # SUBCELLULAR LOCATION BTUD_ECOLI Cell inner membrane; Peripheral membrane protein. # SUBUNIT BTUD_ECOLI The complex is composed of two ATP-binding proteins (BtuD), two transmembrane proteins (BtuC) and a solute-binding protein (BtuF). {ECO 0000255|HAMAP-Rule MF_01005, ECO 0000269|PubMed 12004122}. # SUPFAM SSF52540 SSF52540 # TCDB 3.A.1.13 the atp-binding cassette (abc) superfamily # eggNOG COG4138 LUCA # eggNOG ENOG41080WI Bacteria BLAST swissprot:BTUD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BTUD_ECOLI BioCyc ECOL316407:JW1699-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1699-MONOMER BioCyc EcoCyc:BTUD-MONOMER http://biocyc.org/getid?id=EcoCyc:BTUD-MONOMER BioCyc MetaCyc:BTUD-MONOMER http://biocyc.org/getid?id=MetaCyc:BTUD-MONOMER COG COG4138 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4138 DIP DIP-9234N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9234N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1071142 http://dx.doi.org/10.1126/science.1071142 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.3.33 {ECO:0000255|HAMAP-Rule:MF_01005} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.33 {ECO:0000255|HAMAP-Rule:MF_01005} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M14031 http://www.ebi.ac.uk/ena/data/view/M14031 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.6.3.33 {ECO:0000255|HAMAP-Rule:MF_01005} http://enzyme.expasy.org/EC/3.6.3.33 {ECO:0000255|HAMAP-Rule:MF_01005} EchoBASE EB0126 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0126 EcoGene EG10128 http://www.ecogene.org/geneInfo.php?eg_id=EG10128 EnsemblBacteria AAC74779 http://www.ensemblgenomes.org/id/AAC74779 EnsemblBacteria AAC74779 http://www.ensemblgenomes.org/id/AAC74779 EnsemblBacteria BAA15477 http://www.ensemblgenomes.org/id/BAA15477 EnsemblBacteria BAA15477 http://www.ensemblgenomes.org/id/BAA15477 EnsemblBacteria BAA15477 http://www.ensemblgenomes.org/id/BAA15477 EnsemblBacteria b1709 http://www.ensemblgenomes.org/id/b1709 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0019898 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019898 GO_component GO:0031234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031234 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0015420 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015420 GO_process GO:0015889 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015889 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945751 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945751 HAMAP MF_01005 http://hamap.expasy.org/unirule/MF_01005 InParanoid P06611 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P06611 IntAct P06611 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P06611* IntEnz 3.6.3.33 {ECO:0000255|HAMAP-Rule:MF_01005} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.33 {ECO:0000255|HAMAP-Rule:MF_01005} InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR023693 http://www.ebi.ac.uk/interpro/entry/IPR023693 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1699 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1699 KEGG_Gene eco:b1709 http://www.genome.jp/dbget-bin/www_bget?eco:b1709 KEGG_Orthology KO:K06074 http://www.genome.jp/dbget-bin/www_bget?KO:K06074 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 MINT MINT-6803741 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-6803741 OMA HLAYYAR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HLAYYAR PDB 1L7V http://www.ebi.ac.uk/pdbe-srv/view/entry/1L7V PDB 2QI9 http://www.ebi.ac.uk/pdbe-srv/view/entry/2QI9 PDB 4DBL http://www.ebi.ac.uk/pdbe-srv/view/entry/4DBL PDB 4FI3 http://www.ebi.ac.uk/pdbe-srv/view/entry/4FI3 PDB 4R9U http://www.ebi.ac.uk/pdbe-srv/view/entry/4R9U PDBsum 1L7V http://www.ebi.ac.uk/pdbsum/1L7V PDBsum 2QI9 http://www.ebi.ac.uk/pdbsum/2QI9 PDBsum 4DBL http://www.ebi.ac.uk/pdbsum/4DBL PDBsum 4FI3 http://www.ebi.ac.uk/pdbsum/4FI3 PDBsum 4R9U http://www.ebi.ac.uk/pdbsum/4R9U PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:BTUD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BTUD_ECOLI PSORT-B swissprot:BTUD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BTUD_ECOLI PSORT2 swissprot:BTUD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BTUD_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Phobius swissprot:BTUD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BTUD_ECOLI PhylomeDB P06611 http://phylomedb.org/?seqid=P06611 ProteinModelPortal P06611 http://www.proteinmodelportal.org/query/uniprot/P06611 PubMed 12004122 http://www.ncbi.nlm.nih.gov/pubmed/12004122 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3528129 http://www.ncbi.nlm.nih.gov/pubmed/3528129 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416224 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416224 RefSeq WP_000029474 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000029474 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P06611 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P06611 STRING 511145.b1709 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1709&targetmode=cogs STRING COG4138 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4138&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.13 http://www.tcdb.org/search/result.php?tc=3.A.1.13 UniProtKB BTUD_ECOLI http://www.uniprot.org/uniprot/BTUD_ECOLI UniProtKB-AC P06611 http://www.uniprot.org/uniprot/P06611 charge swissprot:BTUD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BTUD_ECOLI eggNOG COG4138 http://eggnogapi.embl.de/nog_data/html/tree/COG4138 eggNOG ENOG41080WI http://eggnogapi.embl.de/nog_data/html/tree/ENOG41080WI epestfind swissprot:BTUD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BTUD_ECOLI garnier swissprot:BTUD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BTUD_ECOLI helixturnhelix swissprot:BTUD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BTUD_ECOLI hmoment swissprot:BTUD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BTUD_ECOLI iep swissprot:BTUD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BTUD_ECOLI inforesidue swissprot:BTUD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BTUD_ECOLI octanol swissprot:BTUD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BTUD_ECOLI pepcoil swissprot:BTUD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BTUD_ECOLI pepdigest swissprot:BTUD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BTUD_ECOLI pepinfo swissprot:BTUD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BTUD_ECOLI pepnet swissprot:BTUD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BTUD_ECOLI pepstats swissprot:BTUD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BTUD_ECOLI pepwheel swissprot:BTUD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BTUD_ECOLI pepwindow swissprot:BTUD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BTUD_ECOLI sigcleave swissprot:BTUD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BTUD_ECOLI ## Database ID URL or Descriptions # EcoGene EG40008 insH2 # FUNCTION INSH2_ECOLI Involved in the transposition of the insertion sequence IS5. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # InterPro IPR002559 Transposase_11 # InterPro IPR008490 Transposase_InsH_N # Organism INSH2_ECOLI Escherichia coli (strain K12) # Pfam PF01609 DDE_Tnp_1 # Pfam PF05598 DUF772 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSH2_ECOLI Transposase InsH for insertion sequence element IS5B # RefSeq NP_414793 NC_000913.3 # RefSeq NP_415084 NC_000913.3 # RefSeq NP_415189 NC_000913.3 # RefSeq NP_415847 NC_000913.3 # RefSeq NP_416535 NC_000913.3 # RefSeq NP_416696 NC_000913.3 # RefSeq NP_417456 NC_000913.3 # RefSeq NP_417685 NC_000913.3 # RefSeq NP_417962 NC_000913.3 # SIMILARITY Belongs to the transposase 11 family. {ECO 0000305}. # eggNOG COG3039 LUCA # eggNOG ENOG4105F2I Bacteria BLAST swissprot:INSH2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSH2_ECOLI BioCyc EcoCyc:MONOMER0-4234 http://biocyc.org/getid?id=EcoCyc:MONOMER0-4234 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4717 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4717 EcoGene EG40008 http://www.ecogene.org/geneInfo.php?eg_id=EG40008 EnsemblBacteria AAC73653 http://www.ensemblgenomes.org/id/AAC73653 EnsemblBacteria AAC73653 http://www.ensemblgenomes.org/id/AAC73653 EnsemblBacteria BAE76328 http://www.ensemblgenomes.org/id/BAE76328 EnsemblBacteria BAE76328 http://www.ensemblgenomes.org/id/BAE76328 EnsemblBacteria BAE76328 http://www.ensemblgenomes.org/id/BAE76328 EnsemblBacteria b0552 http://www.ensemblgenomes.org/id/b0552 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GeneID 944917 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944917 GeneID 944941 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944941 GeneID 945896 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945896 GeneID 946163 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946163 GeneID 946577 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946577 GeneID 947516 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947516 GeneID 947743 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947743 GeneID 948015 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948015 GeneID 949121 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949121 InParanoid P0CE50 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CE50 InterPro IPR002559 http://www.ebi.ac.uk/interpro/entry/IPR002559 InterPro IPR008490 http://www.ebi.ac.uk/interpro/entry/IPR008490 KEGG_Gene ecj:JW0540 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0540 KEGG_Gene eco:b0259 http://www.genome.jp/dbget-bin/www_bget?eco:b0259 KEGG_Gene eco:b0552 http://www.genome.jp/dbget-bin/www_bget?eco:b0552 KEGG_Gene eco:b0656 http://www.genome.jp/dbget-bin/www_bget?eco:b0656 KEGG_Gene eco:b1331 http://www.genome.jp/dbget-bin/www_bget?eco:b1331 KEGG_Gene eco:b2030 http://www.genome.jp/dbget-bin/www_bget?eco:b2030 KEGG_Gene eco:b2192 http://www.genome.jp/dbget-bin/www_bget?eco:b2192 KEGG_Gene eco:b2982 http://www.genome.jp/dbget-bin/www_bget?eco:b2982 KEGG_Gene eco:b3218 http://www.genome.jp/dbget-bin/www_bget?eco:b3218 KEGG_Gene eco:b3505 http://www.genome.jp/dbget-bin/www_bget?eco:b3505 PSORT swissprot:INSH2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSH2_ECOLI PSORT-B swissprot:INSH2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSH2_ECOLI PSORT2 swissprot:INSH2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSH2_ECOLI Pfam PF01609 http://pfam.xfam.org/family/PF01609 Pfam PF05598 http://pfam.xfam.org/family/PF05598 Phobius swissprot:INSH2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSH2_ECOLI PhylomeDB P0CE50 http://phylomedb.org/?seqid=P0CE50 ProteinModelPortal P0CE50 http://www.proteinmodelportal.org/query/uniprot/P0CE50 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414793 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414793 RefSeq NP_415084 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415084 RefSeq NP_415189 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415189 RefSeq NP_415847 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415847 RefSeq NP_416535 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416535 RefSeq NP_416696 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416696 RefSeq NP_417456 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417456 RefSeq NP_417685 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417685 RefSeq NP_417962 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417962 SMR P0CE50 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0CE50 STRING 511145.b3505 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3505&targetmode=cogs UniProtKB INSH2_ECOLI http://www.uniprot.org/uniprot/INSH2_ECOLI UniProtKB-AC P0CE50 http://www.uniprot.org/uniprot/P0CE50 charge swissprot:INSH2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSH2_ECOLI eggNOG COG3039 http://eggnogapi.embl.de/nog_data/html/tree/COG3039 eggNOG ENOG4105F2I http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F2I epestfind swissprot:INSH2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSH2_ECOLI garnier swissprot:INSH2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSH2_ECOLI helixturnhelix swissprot:INSH2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSH2_ECOLI hmoment swissprot:INSH2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSH2_ECOLI iep swissprot:INSH2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSH2_ECOLI inforesidue swissprot:INSH2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSH2_ECOLI octanol swissprot:INSH2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSH2_ECOLI pepcoil swissprot:INSH2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSH2_ECOLI pepdigest swissprot:INSH2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSH2_ECOLI pepinfo swissprot:INSH2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSH2_ECOLI pepnet swissprot:INSH2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSH2_ECOLI pepstats swissprot:INSH2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSH2_ECOLI pepwheel swissprot:INSH2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSH2_ECOLI pepwindow swissprot:INSH2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSH2_ECOLI sigcleave swissprot:INSH2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSH2_ECOLI ## Database ID URL or Descriptions # BioGrid 4262202 172 # CDD cd06174 MFS # EcoGene EG11566 yaaU # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IBA:GO_Central. # GO_function GO:0022891 substrate-specific transmembrane transporter activity; IBA:GO_Central. # GO_process GO:0006979 response to oxidative stress; IMP:EcoCyc. # GO_process GO:0015850 organic hydroxy compound transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0006950 response to stress # InterPro IPR005828 MFS_sugar_transport-like # InterPro IPR020846 MFS_dom # KEGG_Brite ko02000 Transporters # Organism YAAU_ECOLI Escherichia coli (strain K12) # PATRIC 32115189 VBIEscCol129921_0046 # PIR E64725 E64725 # PROSITE PS50850 MFS # Pfam PF00083 Sugar_tr # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAAU_ECOLI Putative metabolite transport protein YaaU # RefSeq NP_414587 NC_000913.3 # RefSeq WP_001183198 NZ_LN832404.1 # SIMILARITY Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. {ECO 0000305}. # SUBCELLULAR LOCATION YAAU_ECOLI Cell inner membrane {ECO 0000305}; Multi- pass membrane protein {ECO 0000305}. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.1.114 the major facilitator superfamily (mfs) # eggNOG ENOG4105C54 Bacteria # eggNOG ENOG410XQKC LUCA BLAST swissprot:YAAU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAAU_ECOLI BioCyc ECOL316407:JW0044-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0044-MONOMER BioCyc EcoCyc:YAAU-MONOMER http://biocyc.org/getid?id=EcoCyc:YAAU-MONOMER COG COG0477 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0477 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1527 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1527 EcoGene EG11566 http://www.ecogene.org/geneInfo.php?eg_id=EG11566 EnsemblBacteria AAC73156 http://www.ensemblgenomes.org/id/AAC73156 EnsemblBacteria AAC73156 http://www.ensemblgenomes.org/id/AAC73156 EnsemblBacteria BAB96613 http://www.ensemblgenomes.org/id/BAB96613 EnsemblBacteria BAB96613 http://www.ensemblgenomes.org/id/BAB96613 EnsemblBacteria BAB96613 http://www.ensemblgenomes.org/id/BAB96613 EnsemblBacteria b0045 http://www.ensemblgenomes.org/id/b0045 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0022891 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022891 GO_process GO:0006979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979 GO_process GO:0015850 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015850 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 944766 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944766 HOGENOM HOG000077075 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000077075&db=HOGENOM6 InParanoid P31679 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31679 InterPro IPR005828 http://www.ebi.ac.uk/interpro/entry/IPR005828 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0044 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0044 KEGG_Gene eco:b0045 http://www.genome.jp/dbget-bin/www_bget?eco:b0045 KEGG_Orthology KO:K08368 http://www.genome.jp/dbget-bin/www_bget?KO:K08368 OMA CLVIPSQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CLVIPSQ PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:YAAU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAAU_ECOLI PSORT-B swissprot:YAAU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAAU_ECOLI PSORT2 swissprot:YAAU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAAU_ECOLI Pfam PF00083 http://pfam.xfam.org/family/PF00083 Phobius swissprot:YAAU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAAU_ECOLI PhylomeDB P31679 http://phylomedb.org/?seqid=P31679 ProteinModelPortal P31679 http://www.proteinmodelportal.org/query/uniprot/P31679 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414587 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414587 RefSeq WP_001183198 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001183198 STRING 511145.b0045 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0045&targetmode=cogs STRING COG0477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0477&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.1.114 http://www.tcdb.org/search/result.php?tc=2.A.1.1.114 UniProtKB YAAU_ECOLI http://www.uniprot.org/uniprot/YAAU_ECOLI UniProtKB-AC P31679 http://www.uniprot.org/uniprot/P31679 charge swissprot:YAAU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAAU_ECOLI eggNOG ENOG4105C54 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C54 eggNOG ENOG410XQKC http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQKC epestfind swissprot:YAAU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAAU_ECOLI garnier swissprot:YAAU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAAU_ECOLI helixturnhelix swissprot:YAAU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAAU_ECOLI hmoment swissprot:YAAU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAAU_ECOLI iep swissprot:YAAU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAAU_ECOLI inforesidue swissprot:YAAU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAAU_ECOLI octanol swissprot:YAAU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAAU_ECOLI pepcoil swissprot:YAAU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAAU_ECOLI pepdigest swissprot:YAAU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAAU_ECOLI pepinfo swissprot:YAAU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAAU_ECOLI pepnet swissprot:YAAU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAAU_ECOLI pepstats swissprot:YAAU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAAU_ECOLI pepwheel swissprot:YAAU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAAU_ECOLI pepwindow swissprot:YAAU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAAU_ECOLI sigcleave swissprot:YAAU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAAU_ECOLI ## Database ID URL or Descriptions # BioGrid 4260191 92 # CDD cd06261 TM_PBP2 # EcoGene EG13764 ydcU # FUNCTION YDCU_ECOLI Probably part of the binding-protein-dependent transport system YdcSTUV; probably responsible for the translocation of the substrate across the membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006810 transport; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006810 transport # Gene3D 1.10.3720.10 -; 1. # InterPro IPR000515 MetI-like # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00193 Putative spermidine/putrescine transport system # KEGG_Brite ko02000 Transporters # Organism YDCU_ECOLI Escherichia coli (strain K12) # PATRIC 32118174 VBIEscCol129921_1507 # PIR E64896 E64896 # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDCU_ECOLI Inner membrane ABC transporter permease protein YdcU # RefSeq NP_415959 NC_000913.3 # RefSeq WP_001251304 NZ_CP014272.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION YDCU_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF161098 SSF161098 # TCDB 3.A.1.11 the atp-binding cassette (abc) superfamily # eggNOG COG1176 LUCA # eggNOG ENOG4105D81 Bacteria BLAST swissprot:YDCU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDCU_ECOLI BioCyc ECOL316407:JW1437-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1437-MONOMER BioCyc EcoCyc:YDCU-MONOMER http://biocyc.org/getid?id=EcoCyc:YDCU-MONOMER BioCyc MetaCyc:YDCU-MONOMER http://biocyc.org/getid?id=MetaCyc:YDCU-MONOMER COG COG1176 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1176 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3527 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3527 EcoGene EG13764 http://www.ecogene.org/geneInfo.php?eg_id=EG13764 EnsemblBacteria AAC74524 http://www.ensemblgenomes.org/id/AAC74524 EnsemblBacteria AAC74524 http://www.ensemblgenomes.org/id/AAC74524 EnsemblBacteria BAA15071 http://www.ensemblgenomes.org/id/BAA15071 EnsemblBacteria BAA15071 http://www.ensemblgenomes.org/id/BAA15071 EnsemblBacteria BAA15071 http://www.ensemblgenomes.org/id/BAA15071 EnsemblBacteria b1442 http://www.ensemblgenomes.org/id/b1442 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 945976 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945976 HOGENOM HOG000263581 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000263581&db=HOGENOM6 InParanoid P77156 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77156 InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1437 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1437 KEGG_Gene eco:b1442 http://www.genome.jp/dbget-bin/www_bget?eco:b1442 KEGG_Orthology KO:K02054 http://www.genome.jp/dbget-bin/www_bget?KO:K02054 OMA AYYMARY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AYYMARY PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:YDCU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDCU_ECOLI PSORT-B swissprot:YDCU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDCU_ECOLI PSORT2 swissprot:YDCU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDCU_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Phobius swissprot:YDCU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDCU_ECOLI PhylomeDB P77156 http://phylomedb.org/?seqid=P77156 ProteinModelPortal P77156 http://www.proteinmodelportal.org/query/uniprot/P77156 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415959 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415959 RefSeq WP_001251304 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001251304 STRING 511145.b1442 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1442&targetmode=cogs STRING COG1176 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1176&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.11 http://www.tcdb.org/search/result.php?tc=3.A.1.11 UniProtKB YDCU_ECOLI http://www.uniprot.org/uniprot/YDCU_ECOLI UniProtKB-AC P77156 http://www.uniprot.org/uniprot/P77156 charge swissprot:YDCU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDCU_ECOLI eggNOG COG1176 http://eggnogapi.embl.de/nog_data/html/tree/COG1176 eggNOG ENOG4105D81 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D81 epestfind swissprot:YDCU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDCU_ECOLI garnier swissprot:YDCU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDCU_ECOLI helixturnhelix swissprot:YDCU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDCU_ECOLI hmoment swissprot:YDCU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDCU_ECOLI iep swissprot:YDCU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDCU_ECOLI inforesidue swissprot:YDCU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDCU_ECOLI octanol swissprot:YDCU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDCU_ECOLI pepcoil swissprot:YDCU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDCU_ECOLI pepdigest swissprot:YDCU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDCU_ECOLI pepinfo swissprot:YDCU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDCU_ECOLI pepnet swissprot:YDCU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDCU_ECOLI pepstats swissprot:YDCU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDCU_ECOLI pepwheel swissprot:YDCU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDCU_ECOLI pepwindow swissprot:YDCU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDCU_ECOLI sigcleave swissprot:YDCU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDCU_ECOLI ## Database ID URL or Descriptions # BioGrid 4262328 14 # COFACTOR XDHD_ECOLI Name=Mo-molybdopterin; Xref=ChEBI CHEBI 71302; Evidence={ECO 0000250}; Note=Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit. {ECO 0000250}; # COFACTOR XDHD_ECOLI Name=[2Fe-2S] cluster; Xref=ChEBI CHEBI 49601; Evidence={ECO 0000305}; Note=Binds 2 [2Fe-2S] centers. {ECO 0000305}; # EcoGene EG13064 xdhD # FUNCTION XDHD_ECOLI Probably has no xanthine dehydrogenase activity; however deletion results in increased adenine sensitivity, suggesting that this protein contributes to the conversion of adenine to guanine nucleotides during purine salvage. {ECO 0000269|PubMed 10986234}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0004854 xanthine dehydrogenase activity; IBA:GO_Central. # GO_function GO:0005506 iron ion binding; IDA:EcoCyc. # GO_function GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors; IBA:GO_Central. # GO_function GO:0050660 flavin adenine dinucleotide binding; IBA:GO_Central. # GO_function GO:0051537 2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0006166 purine ribonucleoside salvage; IEA:UniProtKB-KW. # GO_process GO:0009115 xanthine catabolic process; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.150.120 -; 1. # Gene3D 3.30.365.10 -; 7. # Gene3D 3.90.1170.50 -; 1. # IntAct Q46814 3 # InterPro IPR000674 Ald_Oxase/Xan_DH_a/b # InterPro IPR002888 2Fe-2S-bd # InterPro IPR008274 AldOxase/xan_DH_Mopterin-bd # InterPro IPR017699 Mo-bd_YgfN/XdhD # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko00450 Selenocompound metabolism # Organism XDHD_ECOLI Escherichia coli (strain K12) # PATRIC 32121172 VBIEscCol129921_2974 # PIR A65072 A65072 # Pfam PF01315 Ald_Xan_dh_C # Pfam PF01799 Fer2_2 # Pfam PF02738 Ald_Xan_dh_C2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName XDHD_ECOLI Probable hypoxanthine oxidase XdhD # RefSeq NP_417357 NC_000913.3 # RefSeq WP_000583615 NZ_LN832404.1 # SIMILARITY Belongs to the xanthine dehydrogenase family. {ECO 0000305}. # SMART SM01008 Ald_Xan_dh_C # SUPFAM SSF47741 SSF47741 # SUPFAM SSF54665 SSF54665 # SUPFAM SSF56003 SSF56003; 2 # TIGRFAMs TIGR03313 Se_sel_red_Mo # eggNOG COG1529 LUCA # eggNOG COG2080 LUCA # eggNOG ENOG4105C7W Bacteria BLAST swissprot:XDHD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:XDHD_ECOLI BioCyc ECOL316407:JW2849-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2849-MONOMER BioCyc EcoCyc:G7500-MONOMER http://biocyc.org/getid?id=EcoCyc:G7500-MONOMER BioCyc MetaCyc:G7500-MONOMER http://biocyc.org/getid?id=MetaCyc:G7500-MONOMER DIP DIP-28056N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-28056N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.19.5332-5341.2000 http://dx.doi.org/10.1128/JB.182.19.5332-5341.2000 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- EchoBASE EB2876 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2876 EcoGene EG13064 http://www.ecogene.org/geneInfo.php?eg_id=EG13064 EnsemblBacteria AAC75919 http://www.ensemblgenomes.org/id/AAC75919 EnsemblBacteria AAC75919 http://www.ensemblgenomes.org/id/AAC75919 EnsemblBacteria BAE76947 http://www.ensemblgenomes.org/id/BAE76947 EnsemblBacteria BAE76947 http://www.ensemblgenomes.org/id/BAE76947 EnsemblBacteria BAE76947 http://www.ensemblgenomes.org/id/BAE76947 EnsemblBacteria b2881 http://www.ensemblgenomes.org/id/b2881 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004854 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004854 GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0016903 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016903 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_function GO:0051537 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051537 GO_process GO:0006166 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006166 GO_process GO:0009115 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009115 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.150.120 http://www.cathdb.info/version/latest/superfamily/1.10.150.120 Gene3D 3.30.365.10 http://www.cathdb.info/version/latest/superfamily/3.30.365.10 Gene3D 3.90.1170.50 http://www.cathdb.info/version/latest/superfamily/3.90.1170.50 GeneID 949079 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949079 HOGENOM HOG000244715 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000244715&db=HOGENOM6 InParanoid Q46814 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46814 IntAct Q46814 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46814* IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR000674 http://www.ebi.ac.uk/interpro/entry/IPR000674 InterPro IPR002888 http://www.ebi.ac.uk/interpro/entry/IPR002888 InterPro IPR008274 http://www.ebi.ac.uk/interpro/entry/IPR008274 InterPro IPR017699 http://www.ebi.ac.uk/interpro/entry/IPR017699 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW2849 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2849 KEGG_Gene eco:b2881 http://www.genome.jp/dbget-bin/www_bget?eco:b2881 KEGG_Orthology KO:K12528 http://www.genome.jp/dbget-bin/www_bget?KO:K12528 KEGG_Pathway ko00450 http://www.genome.jp/kegg-bin/show_pathway?ko00450 OMA NSFMQYK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NSFMQYK PSORT swissprot:XDHD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:XDHD_ECOLI PSORT-B swissprot:XDHD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:XDHD_ECOLI PSORT2 swissprot:XDHD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:XDHD_ECOLI Pfam PF01315 http://pfam.xfam.org/family/PF01315 Pfam PF01799 http://pfam.xfam.org/family/PF01799 Pfam PF02738 http://pfam.xfam.org/family/PF02738 Phobius swissprot:XDHD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:XDHD_ECOLI PhylomeDB Q46814 http://phylomedb.org/?seqid=Q46814 ProteinModelPortal Q46814 http://www.proteinmodelportal.org/query/uniprot/Q46814 PubMed 10986234 http://www.ncbi.nlm.nih.gov/pubmed/10986234 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417357 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417357 RefSeq WP_000583615 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000583615 SMART SM01008 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01008 SMR Q46814 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46814 STRING 511145.b2881 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2881&targetmode=cogs SUPFAM SSF47741 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47741 SUPFAM SSF54665 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54665 SUPFAM SSF56003 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56003 TIGRFAMs TIGR03313 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03313 UniProtKB XDHD_ECOLI http://www.uniprot.org/uniprot/XDHD_ECOLI UniProtKB-AC Q46814 http://www.uniprot.org/uniprot/Q46814 charge swissprot:XDHD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:XDHD_ECOLI eggNOG COG1529 http://eggnogapi.embl.de/nog_data/html/tree/COG1529 eggNOG COG2080 http://eggnogapi.embl.de/nog_data/html/tree/COG2080 eggNOG ENOG4105C7W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C7W epestfind swissprot:XDHD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:XDHD_ECOLI garnier swissprot:XDHD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:XDHD_ECOLI helixturnhelix swissprot:XDHD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:XDHD_ECOLI hmoment swissprot:XDHD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:XDHD_ECOLI iep swissprot:XDHD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:XDHD_ECOLI inforesidue swissprot:XDHD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:XDHD_ECOLI octanol swissprot:XDHD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:XDHD_ECOLI pepcoil swissprot:XDHD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:XDHD_ECOLI pepdigest swissprot:XDHD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:XDHD_ECOLI pepinfo swissprot:XDHD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:XDHD_ECOLI pepnet swissprot:XDHD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:XDHD_ECOLI pepstats swissprot:XDHD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:XDHD_ECOLI pepwheel swissprot:XDHD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:XDHD_ECOLI pepwindow swissprot:XDHD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:XDHD_ECOLI sigcleave swissprot:XDHD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:XDHD_ECOLI ## Database ID URL or Descriptions # AltName Pyrophosphate phospho-hydrolase {ECO:0000255|HAMAP-Rule MF_00209} # BRENDA 3.6.1 2026 # BioGrid 4259312 36 # CATALYTIC ACTIVITY Diphosphate + H(2)O = 2 phosphate. {ECO:0000255|HAMAP-Rule MF_00209}. # CDD cd00412 pyrophosphatase # COFACTOR IPYR_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_00209}; # EcoGene EG10755 ppa # FUNCTION IPYR_ECOLI Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. {ECO 0000255|HAMAP- Rule MF_00209}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0004427 inorganic diphosphatase activity; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IDA:EcoliWiki. # GO_function GO:0050355 triphosphatase activity; IDA:EcoCyc. # GO_process GO:0006796 phosphate-containing compound metabolic process; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # Gene3D 3.90.80.10 -; 1. # HAMAP MF_00209 Inorganic_PPase # IntAct P0A7A9 36 # InterPro IPR008162 Pyrophosphatase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00190 Oxidative phosphorylation # Organism IPYR_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10286 PTHR10286 # PATRIC 32124027 VBIEscCol129921_4358 # PDB 1FAJ X-ray; 2.15 A; A=2-176 # PDB 1I40 X-ray; 1.10 A; A=2-176 # PDB 1I6T X-ray; 1.20 A; A=2-176 # PDB 1IGP X-ray; 2.20 A; A=2-176 # PDB 1INO X-ray; 2.20 A; A=2-176 # PDB 1IPW X-ray; 2.30 A; A/B=2-176 # PDB 1JFD X-ray; 2.20 A; A/B=2-176 # PDB 1MJW X-ray; 1.95 A; A/B=2-176 # PDB 1MJX X-ray; 2.15 A; A/B=2-176 # PDB 1MJY X-ray; 2.10 A; A/B=2-176 # PDB 1MJZ X-ray; 2.20 A; A=2-176 # PDB 1OBW X-ray; 1.90 A; A/B/C=2-176 # PDB 2AU6 X-ray; 1.20 A; A=2-176 # PDB 2AU7 X-ray; 1.05 A; A=2-176 # PDB 2AU8 X-ray; 1.65 A; A=2-176 # PDB 2AU9 X-ray; 1.30 A; A=2-176 # PDB 2AUU X-ray; 1.22 A; A=2-176 # PDB 2EIP X-ray; 2.20 A; A/B=2-176 # PDB 4UM4 X-ray; 2.65 A; A/B/C=1-176 # PIR A27648 PWEC # PROSITE PS00387 PPASE # Pfam PF00719 Pyrophosphatase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Inorganic pyrophosphatase {ECO:0000255|HAMAP-Rule MF_00209} # RefSeq NP_418647 NC_000913.3 # RefSeq WP_000055075 NZ_LN832404.1 # SIMILARITY Belongs to the PPase family. {ECO:0000255|HAMAP- Rule MF_00209}. # SUBCELLULAR LOCATION IPYR_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00209}. # SUBUNIT Homohexamer. {ECO:0000255|HAMAP-Rule MF_00209}. # SUPFAM SSF50324 SSF50324 # eggNOG COG0221 LUCA # eggNOG ENOG4105F0N Bacteria BLAST swissprot:IPYR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:IPYR_ECOLI BioCyc ECOL316407:JW4185-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4185-MONOMER BioCyc EcoCyc:INORGPYROPHOSPHAT-MONOMER http://biocyc.org/getid?id=EcoCyc:INORGPYROPHOSPHAT-MONOMER BioCyc MetaCyc:INORGPYROPHOSPHAT-MONOMER http://biocyc.org/getid?id=MetaCyc:INORGPYROPHOSPHAT-MONOMER COG COG0221 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0221 DIP DIP-36217N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36217N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1016/0020-711X(93)90011-3 http://dx.doi.org/10.1016/0020-711X(93)90011-3 DOI 10.1016/0167-4838(90)90246-C http://dx.doi.org/10.1016/0167-4838(90)90246-C DOI 10.1016/S0014-5793(97)00650-9 http://dx.doi.org/10.1016/S0014-5793(97)00650-9 DOI 10.1021/bi00476a017 http://dx.doi.org/10.1021/bi00476a017 DOI 10.1021/bi952637e http://dx.doi.org/10.1021/bi952637e DOI 10.1021/bi962637u http://dx.doi.org/10.1021/bi962637u DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1093/protein/7.7.823 http://dx.doi.org/10.1093/protein/7.7.823 DOI 10.1107/S0907444996000376 http://dx.doi.org/10.1107/S0907444996000376 DOI 10.1111/j.1432-1033.1991.tb16015.x http://dx.doi.org/10.1111/j.1432-1033.1991.tb16015.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.1.1 {ECO:0000255|HAMAP-Rule:MF_00209} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.1.1 {ECO:0000255|HAMAP-Rule:MF_00209} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M23550 http://www.ebi.ac.uk/ena/data/view/M23550 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 3.6.1.1 {ECO:0000255|HAMAP-Rule:MF_00209} http://enzyme.expasy.org/EC/3.6.1.1 {ECO:0000255|HAMAP-Rule:MF_00209} EchoBASE EB0748 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0748 EcoGene EG10755 http://www.ecogene.org/geneInfo.php?eg_id=EG10755 EnsemblBacteria AAC77183 http://www.ensemblgenomes.org/id/AAC77183 EnsemblBacteria AAC77183 http://www.ensemblgenomes.org/id/AAC77183 EnsemblBacteria BAE78227 http://www.ensemblgenomes.org/id/BAE78227 EnsemblBacteria BAE78227 http://www.ensemblgenomes.org/id/BAE78227 EnsemblBacteria BAE78227 http://www.ensemblgenomes.org/id/BAE78227 EnsemblBacteria b4226 http://www.ensemblgenomes.org/id/b4226 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0004427 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004427 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0050355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050355 GO_process GO:0006796 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006796 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.90.80.10 http://www.cathdb.info/version/latest/superfamily/3.90.80.10 GeneID 948748 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948748 HAMAP MF_00209 http://hamap.expasy.org/unirule/MF_00209 HOGENOM HOG000236473 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000236473&db=HOGENOM6 InParanoid P0A7A9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7A9 IntAct P0A7A9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7A9* IntEnz 3.6.1.1 {ECO:0000255|HAMAP-Rule:MF_00209} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.1.1 {ECO:0000255|HAMAP-Rule:MF_00209} InterPro IPR008162 http://www.ebi.ac.uk/interpro/entry/IPR008162 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4185 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4185 KEGG_Gene eco:b4226 http://www.genome.jp/dbget-bin/www_bget?eco:b4226 KEGG_Orthology KO:K01507 http://www.genome.jp/dbget-bin/www_bget?KO:K01507 KEGG_Pathway ko00190 http://www.genome.jp/kegg-bin/show_pathway?ko00190 MINT MINT-1226708 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1226708 OMA PVDYGII http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PVDYGII PANTHER PTHR10286 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10286 PDB 1FAJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1FAJ PDB 1I40 http://www.ebi.ac.uk/pdbe-srv/view/entry/1I40 PDB 1I6T http://www.ebi.ac.uk/pdbe-srv/view/entry/1I6T PDB 1IGP http://www.ebi.ac.uk/pdbe-srv/view/entry/1IGP PDB 1INO http://www.ebi.ac.uk/pdbe-srv/view/entry/1INO PDB 1IPW http://www.ebi.ac.uk/pdbe-srv/view/entry/1IPW PDB 1JFD http://www.ebi.ac.uk/pdbe-srv/view/entry/1JFD PDB 1MJW http://www.ebi.ac.uk/pdbe-srv/view/entry/1MJW PDB 1MJX http://www.ebi.ac.uk/pdbe-srv/view/entry/1MJX PDB 1MJY http://www.ebi.ac.uk/pdbe-srv/view/entry/1MJY PDB 1MJZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1MJZ PDB 1OBW http://www.ebi.ac.uk/pdbe-srv/view/entry/1OBW PDB 2AU6 http://www.ebi.ac.uk/pdbe-srv/view/entry/2AU6 PDB 2AU7 http://www.ebi.ac.uk/pdbe-srv/view/entry/2AU7 PDB 2AU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/2AU8 PDB 2AU9 http://www.ebi.ac.uk/pdbe-srv/view/entry/2AU9 PDB 2AUU http://www.ebi.ac.uk/pdbe-srv/view/entry/2AUU PDB 2EIP http://www.ebi.ac.uk/pdbe-srv/view/entry/2EIP PDB 4UM4 http://www.ebi.ac.uk/pdbe-srv/view/entry/4UM4 PDBsum 1FAJ http://www.ebi.ac.uk/pdbsum/1FAJ PDBsum 1I40 http://www.ebi.ac.uk/pdbsum/1I40 PDBsum 1I6T http://www.ebi.ac.uk/pdbsum/1I6T PDBsum 1IGP http://www.ebi.ac.uk/pdbsum/1IGP PDBsum 1INO http://www.ebi.ac.uk/pdbsum/1INO PDBsum 1IPW http://www.ebi.ac.uk/pdbsum/1IPW PDBsum 1JFD http://www.ebi.ac.uk/pdbsum/1JFD PDBsum 1MJW http://www.ebi.ac.uk/pdbsum/1MJW PDBsum 1MJX http://www.ebi.ac.uk/pdbsum/1MJX PDBsum 1MJY http://www.ebi.ac.uk/pdbsum/1MJY PDBsum 1MJZ http://www.ebi.ac.uk/pdbsum/1MJZ PDBsum 1OBW http://www.ebi.ac.uk/pdbsum/1OBW PDBsum 2AU6 http://www.ebi.ac.uk/pdbsum/2AU6 PDBsum 2AU7 http://www.ebi.ac.uk/pdbsum/2AU7 PDBsum 2AU8 http://www.ebi.ac.uk/pdbsum/2AU8 PDBsum 2AU9 http://www.ebi.ac.uk/pdbsum/2AU9 PDBsum 2AUU http://www.ebi.ac.uk/pdbsum/2AUU PDBsum 2EIP http://www.ebi.ac.uk/pdbsum/2EIP PDBsum 4UM4 http://www.ebi.ac.uk/pdbsum/4UM4 PROSITE PS00387 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00387 PSORT swissprot:IPYR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:IPYR_ECOLI PSORT-B swissprot:IPYR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:IPYR_ECOLI PSORT2 swissprot:IPYR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:IPYR_ECOLI Pfam PF00719 http://pfam.xfam.org/family/PF00719 Phobius swissprot:IPYR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:IPYR_ECOLI PhylomeDB P0A7A9 http://phylomedb.org/?seqid=P0A7A9 ProteinModelPortal P0A7A9 http://www.proteinmodelportal.org/query/uniprot/P0A7A9 PubMed 15299678 http://www.ncbi.nlm.nih.gov/pubmed/15299678 PubMed 1645654 http://www.ncbi.nlm.nih.gov/pubmed/1645654 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1974462 http://www.ncbi.nlm.nih.gov/pubmed/1974462 PubMed 2160278 http://www.ncbi.nlm.nih.gov/pubmed/2160278 PubMed 2848015 http://www.ncbi.nlm.nih.gov/pubmed/2848015 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 7971944 http://www.ncbi.nlm.nih.gov/pubmed/7971944 PubMed 8383066 http://www.ncbi.nlm.nih.gov/pubmed/8383066 PubMed 8664256 http://www.ncbi.nlm.nih.gov/pubmed/8664256 PubMed 9201917 http://www.ncbi.nlm.nih.gov/pubmed/9201917 PubMed 9237692 http://www.ncbi.nlm.nih.gov/pubmed/9237692 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_418647 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418647 RefSeq WP_000055075 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000055075 SMR P0A7A9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7A9 STRING 511145.b4226 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4226&targetmode=cogs STRING COG0221 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0221&targetmode=cogs SUPFAM SSF50324 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50324 SWISS-2DPAGE P0A7A9 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A7A9 UniProtKB IPYR_ECOLI http://www.uniprot.org/uniprot/IPYR_ECOLI UniProtKB-AC P0A7A9 http://www.uniprot.org/uniprot/P0A7A9 charge swissprot:IPYR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:IPYR_ECOLI eggNOG COG0221 http://eggnogapi.embl.de/nog_data/html/tree/COG0221 eggNOG ENOG4105F0N http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F0N epestfind swissprot:IPYR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:IPYR_ECOLI garnier swissprot:IPYR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:IPYR_ECOLI helixturnhelix swissprot:IPYR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:IPYR_ECOLI hmoment swissprot:IPYR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:IPYR_ECOLI iep swissprot:IPYR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:IPYR_ECOLI inforesidue swissprot:IPYR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:IPYR_ECOLI octanol swissprot:IPYR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:IPYR_ECOLI pepcoil swissprot:IPYR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:IPYR_ECOLI pepdigest swissprot:IPYR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:IPYR_ECOLI pepinfo swissprot:IPYR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:IPYR_ECOLI pepnet swissprot:IPYR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:IPYR_ECOLI pepstats swissprot:IPYR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:IPYR_ECOLI pepwheel swissprot:IPYR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:IPYR_ECOLI pepwindow swissprot:IPYR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:IPYR_ECOLI sigcleave swissprot:IPYR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:IPYR_ECOLI ## Database ID URL or Descriptions # BioGrid 4260427 6 # CDD cd00383 trans_reg_C # DISRUPTION PHENOTYPE BAER_ECOLI Increased sensitivity to membrane stress caused by indole or by overexpression of P pili protein PapG; double baeR-cpxR mutants are more sensitive yet (PubMed 12354228). Loss of induction of the CRISPR-Cas casABCDE-ygbT-ygbF operon (PubMed 21255106). {ECO 0000269|PubMed 12354228, ECO 0000269|PubMed 21255106}. # EcoGene EG11618 baeR # FUNCTION BAER_ECOLI Member of the two-component regulatory system BaeS/BaeR which responds to envelope stress (PubMed 12354228). Activates expression of periplasmic chaperone spy in response to spheroplast formation, indole and P pili protein PapG overexpression (PubMed 12354228). Activates the mdtABCD (PubMed 12107133, PubMed 12107134) and probably the CRISPR-Cas casABCDE-ygbT-ygbF operon (PubMed 21255106). {ECO 0000269|PubMed 12107133, ECO 0000269|PubMed 12107134, ECO 0000269|PubMed 12354228, ECO 0000269|PubMed 21255106}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000986 bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0000160 phosphorelay signal transduction system; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:2000144 positive regulation of DNA-templated transcription, initiation; IDA:EcoCyc. # GO_process GO:2001023 regulation of response to drug; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # INTERACTION BAER_ECOLI Self; NbExp=3; IntAct=EBI-1119567, EBI-1119567; # IntAct P69228 8 # InterPro IPR001789 Sig_transdc_resp-reg_receiver # InterPro IPR001867 OmpR/PhoB-type_DNA-bd # InterPro IPR011006 CheY-like_superfamily # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR016032 Sig_transdc_resp-reg_C-effctor # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02022 M00450 BaeS-BaeR (envelope stress response) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # Organism BAER_ECOLI Escherichia coli (strain K12) # PATRIC 32119491 VBIEscCol129921_2156 # PDB 4B09 X-ray; 3.30 A; A/B/C/D/E/F/G/H/I/J/K/L=1-240 # PIR JX0283 JX0283 # PROSITE PS50110 RESPONSE_REGULATORY # PROSITE PS51755 OMPR_PHOB # PTM BAER_ECOLI Phosphorylated by BaeS. {ECO 0000269|PubMed 15522865}. # Pfam PF00072 Response_reg # Pfam PF00486 Trans_reg_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BAER_ECOLI Transcriptional regulatory protein BaeR # RefSeq NP_416583 NC_000913.3 # RefSeq WP_000137877 NZ_LN832404.1 # SIMILARITY Contains 1 OmpR/PhoB-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU01091}. # SIMILARITY Contains 1 response regulatory domain. {ECO:0000255|PROSITE-ProRule PRU00169}. # SMART SM00448 REC # SMART SM00862 Trans_reg_C # SUBCELLULAR LOCATION BAER_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF46894 SSF46894 # SUPFAM SSF52172 SSF52172 # eggNOG COG0745 LUCA # eggNOG ENOG4105E3W Bacteria BLAST swissprot:BAER_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BAER_ECOLI BioCyc ECOL316407:JW2064-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2064-MONOMER BioCyc EcoCyc:BAER-MONOMER http://biocyc.org/getid?id=EcoCyc:BAER-MONOMER COG COG0745 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0745 DIP DIP-9198N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9198N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2002.03112.x http://dx.doi.org/10.1046/j.1365-2958.2002.03112.x DOI 10.1074/jbc.M410104200 http://dx.doi.org/10.1074/jbc.M410104200 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1111/j.1365-2958.2010.07482.x http://dx.doi.org/10.1111/j.1365-2958.2010.07482.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.15.4161-4167.2002 http://dx.doi.org/10.1128/JB.184.15.4161-4167.2002 DOI 10.1128/JB.184.15.4168-4176.2002 http://dx.doi.org/10.1128/JB.184.15.4168-4176.2002 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D14054 http://www.ebi.ac.uk/ena/data/view/D14054 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1575 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1575 EcoGene EG11618 http://www.ecogene.org/geneInfo.php?eg_id=EG11618 EnsemblBacteria AAC75140 http://www.ensemblgenomes.org/id/AAC75140 EnsemblBacteria AAC75140 http://www.ensemblgenomes.org/id/AAC75140 EnsemblBacteria BAA15935 http://www.ensemblgenomes.org/id/BAA15935 EnsemblBacteria BAA15935 http://www.ensemblgenomes.org/id/BAA15935 EnsemblBacteria BAA15935 http://www.ensemblgenomes.org/id/BAA15935 EnsemblBacteria b2079 http://www.ensemblgenomes.org/id/b2079 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000986 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000986 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GO_process GO:2000144 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000144 GO_process GO:2001023 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2001023 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 946605 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946605 HOGENOM HOG000034819 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000034819&db=HOGENOM6 InParanoid P69228 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P69228 IntAct P69228 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69228* InterPro IPR001789 http://www.ebi.ac.uk/interpro/entry/IPR001789 InterPro IPR001867 http://www.ebi.ac.uk/interpro/entry/IPR001867 InterPro IPR011006 http://www.ebi.ac.uk/interpro/entry/IPR011006 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR016032 http://www.ebi.ac.uk/interpro/entry/IPR016032 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW2064 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2064 KEGG_Gene eco:b2079 http://www.genome.jp/dbget-bin/www_bget?eco:b2079 KEGG_Orthology KO:K07664 http://www.genome.jp/dbget-bin/www_bget?KO:K07664 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA YQASYLG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YQASYLG PDB 4B09 http://www.ebi.ac.uk/pdbe-srv/view/entry/4B09 PDBsum 4B09 http://www.ebi.ac.uk/pdbsum/4B09 PROSITE PS50110 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50110 PROSITE PS51755 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51755 PSORT swissprot:BAER_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BAER_ECOLI PSORT-B swissprot:BAER_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BAER_ECOLI PSORT2 swissprot:BAER_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BAER_ECOLI Pfam PF00072 http://pfam.xfam.org/family/PF00072 Pfam PF00486 http://pfam.xfam.org/family/PF00486 Phobius swissprot:BAER_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BAER_ECOLI PhylomeDB P69228 http://phylomedb.org/?seqid=P69228 ProteinModelPortal P69228 http://www.proteinmodelportal.org/query/uniprot/P69228 PubMed 12107133 http://www.ncbi.nlm.nih.gov/pubmed/12107133 PubMed 12107134 http://www.ncbi.nlm.nih.gov/pubmed/12107134 PubMed 12354228 http://www.ncbi.nlm.nih.gov/pubmed/12354228 PubMed 15522865 http://www.ncbi.nlm.nih.gov/pubmed/15522865 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21255106 http://www.ncbi.nlm.nih.gov/pubmed/21255106 PubMed 8282725 http://www.ncbi.nlm.nih.gov/pubmed/8282725 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416583 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416583 RefSeq WP_000137877 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000137877 SMART SM00448 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00448 SMART SM00862 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00862 SMR P69228 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69228 STRING 511145.b2079 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2079&targetmode=cogs STRING COG0745 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0745&targetmode=cogs SUPFAM SSF46894 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46894 SUPFAM SSF52172 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52172 UniProtKB BAER_ECOLI http://www.uniprot.org/uniprot/BAER_ECOLI UniProtKB-AC P69228 http://www.uniprot.org/uniprot/P69228 charge swissprot:BAER_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BAER_ECOLI eggNOG COG0745 http://eggnogapi.embl.de/nog_data/html/tree/COG0745 eggNOG ENOG4105E3W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E3W epestfind swissprot:BAER_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BAER_ECOLI garnier swissprot:BAER_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BAER_ECOLI helixturnhelix swissprot:BAER_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BAER_ECOLI hmoment swissprot:BAER_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BAER_ECOLI iep swissprot:BAER_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BAER_ECOLI inforesidue swissprot:BAER_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BAER_ECOLI octanol swissprot:BAER_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BAER_ECOLI pepcoil swissprot:BAER_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BAER_ECOLI pepdigest swissprot:BAER_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BAER_ECOLI pepinfo swissprot:BAER_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BAER_ECOLI pepnet swissprot:BAER_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BAER_ECOLI pepstats swissprot:BAER_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BAER_ECOLI pepwheel swissprot:BAER_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BAER_ECOLI pepwindow swissprot:BAER_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BAER_ECOLI sigcleave swissprot:BAER_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BAER_ECOLI ## Database ID URL or Descriptions # FUNCTION INSE6_ECOLI Involved in the transposition of the insertion sequence IS3. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 1.10.10.60 -; 1. # InterPro IPR002514 Transposase_8 # InterPro IPR009057 Homeodomain-like # Organism INSE6_ECOLI Escherichia coli (strain K12) # Pfam PF01527 HTH_Tnp_1 # RecName INSE6_ECOLI Transposase InsE for insertion sequence IS3fA # RefSeq NP_061380 NC_002483.1 # RefSeq NP_061395 NC_002483.1 # RefSeq WP_000169527 NZ_LN832404.1 # SIMILARITY Belongs to the transposase 8 family. {ECO 0000305}. # SUPFAM SSF46689 SSF46689 # eggNOG COG2963 LUCA # eggNOG ENOG41090WB Bacteria BLAST swissprot:INSE6_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSE6_ECOLI EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 GeneID 1263530 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263530 GeneID 1263552 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263552 InterPro IPR002514 http://www.ebi.ac.uk/interpro/entry/IPR002514 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 PSORT swissprot:INSE6_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSE6_ECOLI PSORT-B swissprot:INSE6_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSE6_ECOLI PSORT2 swissprot:INSE6_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSE6_ECOLI Pfam PF01527 http://pfam.xfam.org/family/PF01527 Phobius swissprot:INSE6_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSE6_ECOLI ProteinModelPortal P0CF71 http://www.proteinmodelportal.org/query/uniprot/P0CF71 RefSeq NP_061380 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061380 RefSeq NP_061395 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061395 RefSeq WP_000169527 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000169527 STRING 511145.b2088 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2088&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 UniProtKB INSE6_ECOLI http://www.uniprot.org/uniprot/INSE6_ECOLI UniProtKB-AC P0CF71 http://www.uniprot.org/uniprot/P0CF71 charge swissprot:INSE6_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSE6_ECOLI eggNOG COG2963 http://eggnogapi.embl.de/nog_data/html/tree/COG2963 eggNOG ENOG41090WB http://eggnogapi.embl.de/nog_data/html/tree/ENOG41090WB epestfind swissprot:INSE6_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSE6_ECOLI garnier swissprot:INSE6_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSE6_ECOLI helixturnhelix swissprot:INSE6_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSE6_ECOLI hmoment swissprot:INSE6_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSE6_ECOLI iep swissprot:INSE6_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSE6_ECOLI inforesidue swissprot:INSE6_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSE6_ECOLI octanol swissprot:INSE6_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSE6_ECOLI pepcoil swissprot:INSE6_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSE6_ECOLI pepdigest swissprot:INSE6_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSE6_ECOLI pepinfo swissprot:INSE6_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSE6_ECOLI pepnet swissprot:INSE6_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSE6_ECOLI pepstats swissprot:INSE6_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSE6_ECOLI pepwheel swissprot:INSE6_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSE6_ECOLI pepwindow swissprot:INSE6_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSE6_ECOLI sigcleave swissprot:INSE6_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSE6_ECOLI ## Database ID URL or Descriptions # AltName LPP_ECOLI Braun lipoprotein # AltName LPP_ECOLI Murein-lipoprotein # BioGrid 4260276 199 # EcoGene EG10544 lpp # FUNCTION LPP_ECOLI Interacts with the peptidoglycan both covalently and noncovalently. This interaction contributes to the maintenance of the structural and functional integrity of the cell envelope. # GO_component GO:0009279 cell outer membrane; NAS:UniProtKB. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_component GO:0045203 integral component of cell outer membrane; IDA:EcoCyc. # GO_function GO:0008289 lipid binding; NAS:UniProtKB. # GO_function GO:0042834 peptidoglycan binding; TAS:UniProtKB. # GO_process GO:0030258 lipid modification; IMP:UniProtKB. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008289 lipid binding # GOslim_process GO:0006629 lipid metabolic process # INTERACTION LPP_ECOLI Self; NbExp=2; IntAct=EBI-909750, EBI-909750; P02929 tonB; NbExp=2; IntAct=EBI-909750, EBI-6399993; # IntAct P69776 4 # InterPro IPR006817 Lipoprotein_leucine-zipper_dom # InterPro IPR016367 Murein-lipoprotein # MISCELLANEOUS LPP_ECOLI About one-third of Lpp is covalently bound to peptidoglycan. # Organism LPP_ECOLI Escherichia coli (strain K12) # PATRIC 32118660 VBIEscCol129921_1748 # PDB 1EQ7 X-ray; 1.90 A; A=22-77 # PDB 1JCC X-ray; 1.70 A; A/B/C=22-77 # PDB 1JCD X-ray; 1.30 A; A/B/C=22-73 # PDB 1KFM X-ray; 2.00 A; A=22-77 # PDB 1KFN X-ray; 1.65 A; A=22-77 # PDB 1MLP Model; -; A/B=21-78 # PDB 1T8Z X-ray; 1.45 A; A/B/C/D/E=22-74 # PDB 2GUS X-ray; 1.75 A; A=22-77 # PDB 2GUV X-ray; 1.40 A; A/B/C/D/E=22-77 # PIR A90783 LPECW # PIRSF PIRSF002855 Murein-lipoprotein # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF04728 LPP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LPP_ECOLI Major outer membrane lipoprotein Lpp # RefSeq NP_416192 NC_000913.3 # RefSeq WP_000648420 NZ_LN832404.1 # SIMILARITY Belongs to the Lpp family. {ECO 0000305}. # SUBCELLULAR LOCATION LPP_ECOLI Cell outer membrane {ECO 0000269|PubMed 3013869}; Lipid-anchor {ECO 0000269|PubMed 16079137, ECO 0000269|PubMed 3013869}. Cell outer membrane {ECO 0000269|PubMed 16079137}; Peptidoglycan-anchor {ECO 0000269|PubMed 16079137}. Note=Found in the inner leaflet of the outer membrane. Targeted by the SRP/Sec/YidC pathway. {ECO 0000269|PubMed 16079137}. # SUBUNIT LPP_ECOLI Homotrimer. Seems to interact with TolB, Pal and TonB. Has been isolated from outer membrane preparations as an approximately 87 kDa complex, suggesting it also forms larger complexes. {ECO 0000269|PubMed 10843861, ECO 0000269|PubMed 16079137, ECO 0000269|PubMed 3013869}. # eggNOG COG4238 LUCA # eggNOG ENOG4105KMX Bacteria BLAST swissprot:LPP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LPP_ECOLI BioCyc ECOL316407:JW1667-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1667-MONOMER BioCyc EcoCyc:EG10544-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10544-MONOMER COG COG4238 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4238 DIP DIP-35674N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35674N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/jmbi.2000.3776 http://dx.doi.org/10.1006/jmbi.2000.3776 DOI 10.1016/0022-2836(78)90396-0 http://dx.doi.org/10.1016/0022-2836(78)90396-0 DOI 10.1016/0092-8674(79)90224-1 http://dx.doi.org/10.1016/0092-8674(79)90224-1 DOI 10.1016/S0022-2836(02)00138-9 http://dx.doi.org/10.1016/S0022-2836(02)00138-9 DOI 10.1021/bi026828a http://dx.doi.org/10.1021/bi026828a DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1998.00945.x http://dx.doi.org/10.1046/j.1365-2958.1998.00945.x DOI 10.1073/pnas.0405319101 http://dx.doi.org/10.1073/pnas.0405319101 DOI 10.1073/pnas.74.3.1004 http://dx.doi.org/10.1073/pnas.74.3.1004 DOI 10.1073/pnas.89.16.7546 http://dx.doi.org/10.1073/pnas.89.16.7546 DOI 10.1074/jbc.M208773200 http://dx.doi.org/10.1074/jbc.M208773200 DOI 10.1074/jbc.M403229200 http://dx.doi.org/10.1074/jbc.M403229200 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1111/j.1432-1033.1972.tb01883.x http://dx.doi.org/10.1111/j.1432-1033.1972.tb01883.x DOI 10.1111/j.1432-1033.1973.tb02757.x http://dx.doi.org/10.1111/j.1432-1033.1973.tb02757.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.3.754-759.2002 http://dx.doi.org/10.1128/JB.184.3.754-759.2002 DOI 10.1128/JB.184.6.1640-1648.2002 http://dx.doi.org/10.1128/JB.184.6.1640-1648.2002 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL S42225 http://www.ebi.ac.uk/ena/data/view/S42225 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00302 http://www.ebi.ac.uk/ena/data/view/V00302 EMBL X68953 http://www.ebi.ac.uk/ena/data/view/X68953 EchoBASE EB0539 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0539 EcoGene EG10544 http://www.ecogene.org/geneInfo.php?eg_id=EG10544 EnsemblBacteria AAC74747 http://www.ensemblgenomes.org/id/AAC74747 EnsemblBacteria AAC74747 http://www.ensemblgenomes.org/id/AAC74747 EnsemblBacteria BAA16044 http://www.ensemblgenomes.org/id/BAA16044 EnsemblBacteria BAA16044 http://www.ensemblgenomes.org/id/BAA16044 EnsemblBacteria BAA16044 http://www.ensemblgenomes.org/id/BAA16044 EnsemblBacteria b1677 http://www.ensemblgenomes.org/id/b1677 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0045203 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045203 GO_function GO:0008289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289 GO_function GO:0042834 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042834 GO_process GO:0030258 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030258 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GeneID 946175 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946175 HOGENOM HOG000295473 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000295473&db=HOGENOM6 IntAct P69776 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69776* InterPro IPR006817 http://www.ebi.ac.uk/interpro/entry/IPR006817 InterPro IPR016367 http://www.ebi.ac.uk/interpro/entry/IPR016367 KEGG_Gene ecj:JW1667 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1667 KEGG_Gene eco:b1677 http://www.genome.jp/dbget-bin/www_bget?eco:b1677 KEGG_Orthology KO:K06078 http://www.genome.jp/dbget-bin/www_bget?KO:K06078 OMA NCASTNK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NCASTNK PDB 1EQ7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1EQ7 PDB 1JCC http://www.ebi.ac.uk/pdbe-srv/view/entry/1JCC PDB 1JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/1JCD PDB 1KFM http://www.ebi.ac.uk/pdbe-srv/view/entry/1KFM PDB 1KFN http://www.ebi.ac.uk/pdbe-srv/view/entry/1KFN PDB 1MLP http://www.ebi.ac.uk/pdbe-srv/view/entry/1MLP PDB 1T8Z http://www.ebi.ac.uk/pdbe-srv/view/entry/1T8Z PDB 2GUS http://www.ebi.ac.uk/pdbe-srv/view/entry/2GUS PDB 2GUV http://www.ebi.ac.uk/pdbe-srv/view/entry/2GUV PDBsum 1EQ7 http://www.ebi.ac.uk/pdbsum/1EQ7 PDBsum 1JCC http://www.ebi.ac.uk/pdbsum/1JCC PDBsum 1JCD http://www.ebi.ac.uk/pdbsum/1JCD PDBsum 1KFM http://www.ebi.ac.uk/pdbsum/1KFM PDBsum 1KFN http://www.ebi.ac.uk/pdbsum/1KFN PDBsum 1MLP http://www.ebi.ac.uk/pdbsum/1MLP PDBsum 1T8Z http://www.ebi.ac.uk/pdbsum/1T8Z PDBsum 2GUS http://www.ebi.ac.uk/pdbsum/2GUS PDBsum 2GUV http://www.ebi.ac.uk/pdbsum/2GUV PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:LPP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LPP_ECOLI PSORT-B swissprot:LPP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LPP_ECOLI PSORT2 swissprot:LPP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LPP_ECOLI Pfam PF04728 http://pfam.xfam.org/family/PF04728 Phobius swissprot:LPP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LPP_ECOLI ProteinModelPortal P69776 http://www.proteinmodelportal.org/query/uniprot/P69776 PubMed 10843861 http://www.ncbi.nlm.nih.gov/pubmed/10843861 PubMed 11790745 http://www.ncbi.nlm.nih.gov/pubmed/11790745 PubMed 11872715 http://www.ncbi.nlm.nih.gov/pubmed/11872715 PubMed 12054830 http://www.ncbi.nlm.nih.gov/pubmed/12054830 PubMed 12368282 http://www.ncbi.nlm.nih.gov/pubmed/12368282 PubMed 12741822 http://www.ncbi.nlm.nih.gov/pubmed/12741822 PubMed 1380161 http://www.ncbi.nlm.nih.gov/pubmed/1380161 PubMed 15140892 http://www.ncbi.nlm.nih.gov/pubmed/15140892 PubMed 1527073 http://www.ncbi.nlm.nih.gov/pubmed/1527073 PubMed 15520380 http://www.ncbi.nlm.nih.gov/pubmed/15520380 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3013869 http://www.ncbi.nlm.nih.gov/pubmed/3013869 PubMed 322142 http://www.ncbi.nlm.nih.gov/pubmed/322142 PubMed 353292 http://www.ncbi.nlm.nih.gov/pubmed/353292 PubMed 391404 http://www.ncbi.nlm.nih.gov/pubmed/391404 PubMed 4261992 http://www.ncbi.nlm.nih.gov/pubmed/4261992 PubMed 4575979 http://www.ncbi.nlm.nih.gov/pubmed/4575979 PubMed 6765942 http://www.ncbi.nlm.nih.gov/pubmed/6765942 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9139900 http://www.ncbi.nlm.nih.gov/pubmed/9139900 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9701827 http://www.ncbi.nlm.nih.gov/pubmed/9701827 RefSeq NP_416192 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416192 RefSeq WP_000648420 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000648420 SMR P69776 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69776 STRING 511145.b1677 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1677&targetmode=cogs STRING COG4238 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4238&targetmode=cogs UniProtKB LPP_ECOLI http://www.uniprot.org/uniprot/LPP_ECOLI UniProtKB-AC P69776 http://www.uniprot.org/uniprot/P69776 charge swissprot:LPP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LPP_ECOLI eggNOG COG4238 http://eggnogapi.embl.de/nog_data/html/tree/COG4238 eggNOG ENOG4105KMX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KMX epestfind swissprot:LPP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LPP_ECOLI garnier swissprot:LPP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LPP_ECOLI helixturnhelix swissprot:LPP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LPP_ECOLI hmoment swissprot:LPP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LPP_ECOLI iep swissprot:LPP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LPP_ECOLI inforesidue swissprot:LPP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LPP_ECOLI octanol swissprot:LPP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LPP_ECOLI pepcoil swissprot:LPP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LPP_ECOLI pepdigest swissprot:LPP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LPP_ECOLI pepinfo swissprot:LPP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LPP_ECOLI pepnet swissprot:LPP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LPP_ECOLI pepstats swissprot:LPP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LPP_ECOLI pepwheel swissprot:LPP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LPP_ECOLI pepwindow swissprot:LPP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LPP_ECOLI sigcleave swissprot:LPP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LPP_ECOLI ## Database ID URL or Descriptions # AltName EIIC-Gut {ECO:0000303|PubMed 3553176} # AltName Glucitol/sorbitol permease IIC component {ECO:0000303|PubMed 3553176} # BioGrid 4262078 18 # DOMAIN PTHC_ECOLI The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site. {ECO 0000255|PROSITE-ProRule PRU00430}. # EcoGene EG10969 srlA # FUNCTION PTHC_ECOLI The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. The enzyme II complex composed of SrlA, SrlB and SrlE is involved in glucitol/sorbitol transport. It can also use D- mannitol. {ECO 0000269|PubMed 1100608}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006810 transport # INDUCTION Regulated by an unusual system which consists of the activator GutM and the repressor GutR in addition to the cAMP-CRP complex. {ECO:0000269|PubMed 3062173}. # InterPro IPR004699 PTS_IID_sorb # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00280 PTS system, glucitol/sorbitol-specific II component # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko00051 Fructose and mannose metabolism # KEGG_Pathway ko02060 Phosphotransferase system (PTS) # Organism PTHC_ECOLI Escherichia coli (strain K12) # PATRIC 32120802 VBIEscCol129921_2793 # PIR A26725 WQEC2S # PIRSF PIRSF038321 PTS_glc_srb_IIC # PROSITE PS51107 PTS_EIIC_TYPE_5 # Pfam PF03608 EII-GUT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PTS system glucitol/sorbitol-specific EIIC component {ECO:0000303|PubMed 3553176} # RefSeq WP_000573321 NZ_LN832404.1 # RefSeq YP_026180 NC_000913.3 # SIMILARITY Contains 1 PTS EIIC type-5 domain. {ECO:0000255|PROSITE-ProRule PRU00430}. # SUBCELLULAR LOCATION PTHC_ECOLI Cell inner membrane {ECO 0000255|PROSITE- ProRule PRU00430, ECO 0000305|PubMed 3553176}; Multi-pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00430, ECO 0000305|PubMed 3553176}. # TCDB 4.A.4.1 the pts glucitol (gut) family # TIGRFAMs TIGR00821 EII-GUT # eggNOG COG3730 LUCA # eggNOG ENOG410787A Bacteria BLAST swissprot:PTHC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTHC_ECOLI BioCyc ECOL316407:JW5429-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5429-MONOMER BioCyc EcoCyc:G8210-MONOMER http://biocyc.org/getid?id=EcoCyc:G8210-MONOMER BioCyc MetaCyc:G8210-MONOMER http://biocyc.org/getid?id=MetaCyc:G8210-MONOMER COG COG3730 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3730 COG COG3732 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3732 DOI 10.1016/0022-2836(88)90193-3 http://dx.doi.org/10.1016/0022-2836(88)90193-3 DOI 10.1038/360606a0 http://dx.doi.org/10.1038/360606a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J02708 http://www.ebi.ac.uk/ena/data/view/J02708 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X70016 http://www.ebi.ac.uk/ena/data/view/X70016 EchoBASE EB0962 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0962 EcoGene EG10969 http://www.ecogene.org/geneInfo.php?eg_id=EG10969 EnsemblBacteria AAT48148 http://www.ensemblgenomes.org/id/AAT48148 EnsemblBacteria AAT48148 http://www.ensemblgenomes.org/id/AAT48148 EnsemblBacteria BAA18886 http://www.ensemblgenomes.org/id/BAA18886 EnsemblBacteria BAA18886 http://www.ensemblgenomes.org/id/BAA18886 EnsemblBacteria BAA18886 http://www.ensemblgenomes.org/id/BAA18886 EnsemblBacteria b2702 http://www.ensemblgenomes.org/id/b2702 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 947575 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947575 HOGENOM HOG000242767 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000242767&db=HOGENOM6 InParanoid P56579 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P56579 IntAct P56579 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P56579* InterPro IPR004699 http://www.ebi.ac.uk/interpro/entry/IPR004699 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5429 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5429 KEGG_Gene eco:b2702 http://www.genome.jp/dbget-bin/www_bget?eco:b2702 KEGG_Orthology KO:K02783 http://www.genome.jp/dbget-bin/www_bget?KO:K02783 KEGG_Pathway ko00051 http://www.genome.jp/kegg-bin/show_pathway?ko00051 KEGG_Pathway ko02060 http://www.genome.jp/kegg-bin/show_pathway?ko02060 KEGG_Reaction rn:R05820 http://www.genome.jp/dbget-bin/www_bget?rn:R05820 OMA HINPGEY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HINPGEY PROSITE PS51107 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51107 PSORT swissprot:PTHC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTHC_ECOLI PSORT-B swissprot:PTHC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTHC_ECOLI PSORT2 swissprot:PTHC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTHC_ECOLI Pfam PF03608 http://pfam.xfam.org/family/PF03608 Phobius swissprot:PTHC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTHC_ECOLI PhylomeDB P56579 http://phylomedb.org/?seqid=P56579 ProteinModelPortal P56579 http://www.proteinmodelportal.org/query/uniprot/P56579 PubMed 1100608 http://www.ncbi.nlm.nih.gov/pubmed/1100608 PubMed 1334233 http://www.ncbi.nlm.nih.gov/pubmed/1334233 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3062173 http://www.ncbi.nlm.nih.gov/pubmed/3062173 PubMed 3553176 http://www.ncbi.nlm.nih.gov/pubmed/3553176 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000573321 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000573321 RefSeq YP_026180 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026180 SMR P56579 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P56579 STRING 511145.b2702 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2702&targetmode=cogs STRING COG3730 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3730&targetmode=cogs STRING COG3732 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3732&targetmode=cogs TCDB 4.A.4.1 http://www.tcdb.org/search/result.php?tc=4.A.4.1 TIGRFAMs TIGR00821 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00821 UniProtKB PTHC_ECOLI http://www.uniprot.org/uniprot/PTHC_ECOLI UniProtKB-AC P56579 http://www.uniprot.org/uniprot/P56579 charge swissprot:PTHC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTHC_ECOLI eggNOG COG3730 http://eggnogapi.embl.de/nog_data/html/tree/COG3730 eggNOG ENOG410787A http://eggnogapi.embl.de/nog_data/html/tree/ENOG410787A epestfind swissprot:PTHC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTHC_ECOLI garnier swissprot:PTHC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTHC_ECOLI helixturnhelix swissprot:PTHC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTHC_ECOLI hmoment swissprot:PTHC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTHC_ECOLI iep swissprot:PTHC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTHC_ECOLI inforesidue swissprot:PTHC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTHC_ECOLI octanol swissprot:PTHC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTHC_ECOLI pepcoil swissprot:PTHC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTHC_ECOLI pepdigest swissprot:PTHC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTHC_ECOLI pepinfo swissprot:PTHC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTHC_ECOLI pepnet swissprot:PTHC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTHC_ECOLI pepstats swissprot:PTHC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTHC_ECOLI pepwheel swissprot:PTHC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTHC_ECOLI pepwindow swissprot:PTHC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTHC_ECOLI sigcleave swissprot:PTHC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTHC_ECOLI ## Database ID URL or Descriptions # EcoGene EG11405 cydD # FUNCTION CYDD_ECOLI Somehow involved in the cytochrome D branch of aerobic respiration. Seems to be a component of a transport system. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:EcoCyc. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; ISM:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016887 ATPase activity; IDA:EcoCyc. # GO_function GO:0034040 lipid-transporting ATPase activity; IBA:GO_Central. # GO_function GO:0042626 ATPase activity, coupled to transmembrane movement of substances; IDA:EcoCyc. # GO_process GO:0033228 cysteine export; IDA:EcoCyc. # GO_process GO:0034775 glutathione transmembrane transport; IDA:EcoCyc. # GO_process GO:0045454 cell redox homeostasis; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # GOslim_process GO:0042592 homeostatic process # GOslim_process GO:0055085 transmembrane transport # Gene3D 3.40.50.300 -; 1. # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR011527 ABC1_TM_dom # InterPro IPR014216 ABC_transptr_CydD # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # MISCELLANEOUS CYDD_ECOLI Required for growth at high temperatures. # Organism CYDD_ECOLI Escherichia coli (strain K12) # PATRIC 32116983 VBIEscCol129921_0916 # PIR F64827 F64827 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # PROSITE PS50929 ABC_TM1F # Pfam PF00005 ABC_tran # Pfam PF00664 ABC_membrane # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CYDD_ECOLI ATP-binding/permease protein CydD # RefSeq NP_415407 NC_000913.3 # RefSeq WP_001043598 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA23995.1; Type=Frameshift; Positions=102; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ABC transporter superfamily. Cysteine exporter (TC 3.A.1.129.1) family. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA # SUBCELLULAR LOCATION CYDD_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00441, ECO 0000269|PubMed 15919996}. # SUPFAM SSF52540 SSF52540 # SUPFAM SSF90123 SSF90123 # TCDB 3.A.1.129 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR02857 CydD # eggNOG COG4988 LUCA # eggNOG ENOG4108JJ9 Bacteria BLAST swissprot:CYDD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CYDD_ECOLI BioCyc ECOL316407:JW0870-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0870-MONOMER BioCyc EcoCyc:CYDD-MONOMER http://biocyc.org/getid?id=EcoCyc:CYDD-MONOMER BioCyc MetaCyc:CYDD-MONOMER http://biocyc.org/getid?id=MetaCyc:CYDD-MONOMER COG COG4988 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4988 DIP DIP-9363N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9363N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1101/gad.7.12b.2629 http://dx.doi.org/10.1101/gad.7.12b.2629 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L21749 http://www.ebi.ac.uk/ena/data/view/L21749 EMBL L25859 http://www.ebi.ac.uk/ena/data/view/L25859 EMBL M95935 http://www.ebi.ac.uk/ena/data/view/M95935 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1377 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1377 EcoGene EG11405 http://www.ecogene.org/geneInfo.php?eg_id=EG11405 EnsemblBacteria AAC73973 http://www.ensemblgenomes.org/id/AAC73973 EnsemblBacteria AAC73973 http://www.ensemblgenomes.org/id/AAC73973 EnsemblBacteria BAA35612 http://www.ensemblgenomes.org/id/BAA35612 EnsemblBacteria BAA35612 http://www.ensemblgenomes.org/id/BAA35612 EnsemblBacteria BAA35612 http://www.ensemblgenomes.org/id/BAA35612 EnsemblBacteria b0887 http://www.ensemblgenomes.org/id/b0887 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_function GO:0034040 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034040 GO_function GO:0042626 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042626 GO_process GO:0033228 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033228 GO_process GO:0034775 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034775 GO_process GO:0045454 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045454 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 949052 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949052 InParanoid P29018 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P29018 IntAct P29018 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P29018* InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR011527 http://www.ebi.ac.uk/interpro/entry/IPR011527 InterPro IPR014216 http://www.ebi.ac.uk/interpro/entry/IPR014216 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0870 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0870 KEGG_Gene eco:b0887 http://www.genome.jp/dbget-bin/www_bget?eco:b0887 KEGG_Orthology KO:K16013 http://www.genome.jp/dbget-bin/www_bget?KO:K16013 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA LGFLPYQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LGFLPYQ PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PROSITE PS50929 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50929 PSORT swissprot:CYDD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CYDD_ECOLI PSORT-B swissprot:CYDD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CYDD_ECOLI PSORT2 swissprot:CYDD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CYDD_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Pfam PF00664 http://pfam.xfam.org/family/PF00664 Phobius swissprot:CYDD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CYDD_ECOLI PhylomeDB P29018 http://phylomedb.org/?seqid=P29018 ProteinModelPortal P29018 http://www.proteinmodelportal.org/query/uniprot/P29018 PubMed 1310500 http://www.ncbi.nlm.nih.gov/pubmed/1310500 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7934832 http://www.ncbi.nlm.nih.gov/pubmed/7934832 PubMed 8276245 http://www.ncbi.nlm.nih.gov/pubmed/8276245 PubMed 8380150 http://www.ncbi.nlm.nih.gov/pubmed/8380150 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415407 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415407 RefSeq WP_001043598 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001043598 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P29018 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P29018 STRING 511145.b0887 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0887&targetmode=cogs STRING COG4988 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4988&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SUPFAM SSF90123 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90123 TCDB 3.A.1.129 http://www.tcdb.org/search/result.php?tc=3.A.1.129 TIGRFAMs TIGR02857 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02857 UniProtKB CYDD_ECOLI http://www.uniprot.org/uniprot/CYDD_ECOLI UniProtKB-AC P29018 http://www.uniprot.org/uniprot/P29018 charge swissprot:CYDD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CYDD_ECOLI eggNOG COG4988 http://eggnogapi.embl.de/nog_data/html/tree/COG4988 eggNOG ENOG4108JJ9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108JJ9 epestfind swissprot:CYDD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CYDD_ECOLI garnier swissprot:CYDD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CYDD_ECOLI helixturnhelix swissprot:CYDD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CYDD_ECOLI hmoment swissprot:CYDD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CYDD_ECOLI iep swissprot:CYDD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CYDD_ECOLI inforesidue swissprot:CYDD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CYDD_ECOLI octanol swissprot:CYDD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CYDD_ECOLI pepcoil swissprot:CYDD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CYDD_ECOLI pepdigest swissprot:CYDD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CYDD_ECOLI pepinfo swissprot:CYDD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CYDD_ECOLI pepnet swissprot:CYDD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CYDD_ECOLI pepstats swissprot:CYDD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CYDD_ECOLI pepwheel swissprot:CYDD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CYDD_ECOLI pepwindow swissprot:CYDD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CYDD_ECOLI sigcleave swissprot:CYDD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CYDD_ECOLI ## Database ID URL or Descriptions # BioGrid 4261300 380 # EcoGene EG13944 ydhJ # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015238 drug transmembrane transporter activity; IBA:GO_Central. # GO_process GO:0046942 carboxylic acid transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR006143 RND_pump_MFP # InterPro IPR032317 HlyD_D23 # Organism YDHJ_ECOLI Escherichia coli (strain K12) # PATRIC 32118590 VBIEscCol129921_1715 # PIR F64921 F64921 # Pfam PF00529 HlyD # Pfam PF16576 HlyD_D23 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDHJ_ECOLI Uncharacterized protein YdhJ # RefSeq NP_416161 NC_000913.3 # RefSeq WP_001300356 NZ_LN832404.1 # SIMILARITY Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. {ECO 0000305}. # SUBCELLULAR LOCATION YDHJ_ECOLI Membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. # TIGRFAMs TIGR01730 RND_mfp # eggNOG COG1566 LUCA # eggNOG ENOG4105Y49 Bacteria BLAST swissprot:YDHJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDHJ_ECOLI BioCyc ECOL316407:JW1636-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1636-MONOMER BioCyc EcoCyc:G6884-MONOMER http://biocyc.org/getid?id=EcoCyc:G6884-MONOMER DIP DIP-11733N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11733N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3702 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3702 EcoGene EG13944 http://www.ecogene.org/geneInfo.php?eg_id=EG13944 EnsemblBacteria AAC74716 http://www.ensemblgenomes.org/id/AAC74716 EnsemblBacteria AAC74716 http://www.ensemblgenomes.org/id/AAC74716 EnsemblBacteria BAA15404 http://www.ensemblgenomes.org/id/BAA15404 EnsemblBacteria BAA15404 http://www.ensemblgenomes.org/id/BAA15404 EnsemblBacteria BAA15404 http://www.ensemblgenomes.org/id/BAA15404 EnsemblBacteria b1644 http://www.ensemblgenomes.org/id/b1644 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015238 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015238 GO_process GO:0046942 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046942 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 946499 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946499 HOGENOM HOG000112073 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000112073&db=HOGENOM6 InParanoid P76185 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76185 IntAct P76185 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76185* InterPro IPR006143 http://www.ebi.ac.uk/interpro/entry/IPR006143 InterPro IPR032317 http://www.ebi.ac.uk/interpro/entry/IPR032317 KEGG_Gene ecj:JW1636 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1636 KEGG_Gene eco:b1644 http://www.genome.jp/dbget-bin/www_bget?eco:b1644 OMA WHIDRTA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WHIDRTA PSORT swissprot:YDHJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDHJ_ECOLI PSORT-B swissprot:YDHJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDHJ_ECOLI PSORT2 swissprot:YDHJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDHJ_ECOLI Pfam PF00529 http://pfam.xfam.org/family/PF00529 Pfam PF16576 http://pfam.xfam.org/family/PF16576 Phobius swissprot:YDHJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDHJ_ECOLI PhylomeDB P76185 http://phylomedb.org/?seqid=P76185 ProteinModelPortal P76185 http://www.proteinmodelportal.org/query/uniprot/P76185 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416161 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416161 RefSeq WP_001300356 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300356 SMR P76185 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76185 STRING 511145.b1644 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1644&targetmode=cogs TIGRFAMs TIGR01730 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01730 UniProtKB YDHJ_ECOLI http://www.uniprot.org/uniprot/YDHJ_ECOLI UniProtKB-AC P76185 http://www.uniprot.org/uniprot/P76185 charge swissprot:YDHJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDHJ_ECOLI eggNOG COG1566 http://eggnogapi.embl.de/nog_data/html/tree/COG1566 eggNOG ENOG4105Y49 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105Y49 epestfind swissprot:YDHJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDHJ_ECOLI garnier swissprot:YDHJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDHJ_ECOLI helixturnhelix swissprot:YDHJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDHJ_ECOLI hmoment swissprot:YDHJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDHJ_ECOLI iep swissprot:YDHJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDHJ_ECOLI inforesidue swissprot:YDHJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDHJ_ECOLI octanol swissprot:YDHJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDHJ_ECOLI pepcoil swissprot:YDHJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDHJ_ECOLI pepdigest swissprot:YDHJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDHJ_ECOLI pepinfo swissprot:YDHJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDHJ_ECOLI pepnet swissprot:YDHJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDHJ_ECOLI pepstats swissprot:YDHJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDHJ_ECOLI pepwheel swissprot:YDHJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDHJ_ECOLI pepwindow swissprot:YDHJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDHJ_ECOLI sigcleave swissprot:YDHJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDHJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4259112 3 # EcoGene EG11639 eamA # FUNCTION EAMA_ECOLI May be an export pump for cysteine and other metabolites of the cysteine pathway (such as N-acetyl-L-serine (NAS) and O- acetyl-L-serine (OAS)), and for other amino acids and their metabolites. {ECO 0000269|PubMed 10844694, ECO 0000269|Ref.6}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IDA:EcoCyc. # GO_function GO:0015562 efflux transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0033228 cysteine export; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR000620 EamA_dom # KEGG_Brite ko02000 Transporters # Organism EAMA_ECOLI Escherichia coli (strain K12) # PATRIC 32118364 VBIEscCol129921_1602 # PIR H64907 H64907 # Pfam PF00892 EamA; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EAMA_ECOLI Probable amino-acid metabolite efflux pump # RefSeq NP_416050 NC_000913.3 # RefSeq WP_000087187 NZ_LN832404.1 # SIMILARITY Belongs to the EamA transporter family. {ECO 0000305}. # SIMILARITY Contains 2 EamA domains. {ECO 0000305}. # SUBCELLULAR LOCATION EAMA_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.7.3 the drug/metabolite transporter (dmt) superfamily # eggNOG COG0697 LUCA # eggNOG ENOG4108594 Bacteria BLAST swissprot:EAMA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EAMA_ECOLI BioCyc ECOL316407:JW5250-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5250-MONOMER BioCyc EcoCyc:EG11639-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11639-MONOMER BioCyc MetaCyc:EG11639-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11639-MONOMER COG COG0697 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0697 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2000.01924.x http://dx.doi.org/10.1046/j.1365-2958.2000.01924.x DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M96235 http://www.ebi.ac.uk/ena/data/view/M96235 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1594 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1594 EcoGene EG11639 http://www.ecogene.org/geneInfo.php?eg_id=EG11639 EnsemblBacteria AAC74606 http://www.ensemblgenomes.org/id/AAC74606 EnsemblBacteria AAC74606 http://www.ensemblgenomes.org/id/AAC74606 EnsemblBacteria BAA15223 http://www.ensemblgenomes.org/id/BAA15223 EnsemblBacteria BAA15223 http://www.ensemblgenomes.org/id/BAA15223 EnsemblBacteria BAA15223 http://www.ensemblgenomes.org/id/BAA15223 EnsemblBacteria b1533 http://www.ensemblgenomes.org/id/b1533 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015562 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015562 GO_process GO:0033228 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033228 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 946081 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946081 HOGENOM HOG000184107 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000184107&db=HOGENOM6 InParanoid P31125 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31125 InterPro IPR000620 http://www.ebi.ac.uk/interpro/entry/IPR000620 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5250 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5250 KEGG_Gene eco:b1533 http://www.genome.jp/dbget-bin/www_bget?eco:b1533 KEGG_Orthology KO:K15268 http://www.genome.jp/dbget-bin/www_bget?KO:K15268 OMA MTISFGQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MTISFGQ PSORT swissprot:EAMA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EAMA_ECOLI PSORT-B swissprot:EAMA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EAMA_ECOLI PSORT2 swissprot:EAMA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EAMA_ECOLI Pfam PF00892 http://pfam.xfam.org/family/PF00892 Phobius swissprot:EAMA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EAMA_ECOLI PhylomeDB P31125 http://phylomedb.org/?seqid=P31125 ProteinModelPortal P31125 http://www.proteinmodelportal.org/query/uniprot/P31125 PubMed 10844694 http://www.ncbi.nlm.nih.gov/pubmed/10844694 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8383113 http://www.ncbi.nlm.nih.gov/pubmed/8383113 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416050 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416050 RefSeq WP_000087187 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000087187 STRING 511145.b1533 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1533&targetmode=cogs STRING COG0697 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0697&targetmode=cogs TCDB 2.A.7.3 http://www.tcdb.org/search/result.php?tc=2.A.7.3 UniProtKB EAMA_ECOLI http://www.uniprot.org/uniprot/EAMA_ECOLI UniProtKB-AC P31125 http://www.uniprot.org/uniprot/P31125 charge swissprot:EAMA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EAMA_ECOLI eggNOG COG0697 http://eggnogapi.embl.de/nog_data/html/tree/COG0697 eggNOG ENOG4108594 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108594 epestfind swissprot:EAMA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EAMA_ECOLI garnier swissprot:EAMA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EAMA_ECOLI helixturnhelix swissprot:EAMA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EAMA_ECOLI hmoment swissprot:EAMA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EAMA_ECOLI iep swissprot:EAMA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EAMA_ECOLI inforesidue swissprot:EAMA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EAMA_ECOLI octanol swissprot:EAMA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EAMA_ECOLI pepcoil swissprot:EAMA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EAMA_ECOLI pepdigest swissprot:EAMA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EAMA_ECOLI pepinfo swissprot:EAMA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EAMA_ECOLI pepnet swissprot:EAMA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EAMA_ECOLI pepstats swissprot:EAMA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EAMA_ECOLI pepwheel swissprot:EAMA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EAMA_ECOLI pepwindow swissprot:EAMA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EAMA_ECOLI sigcleave swissprot:EAMA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EAMA_ECOLI ## Database ID URL or Descriptions # EcoGene EG14484 yohP # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # INDUCTION YOHP_ECOLI Expressed in exponential phase, strongly induced in stationary phase (PubMed 19121005) and in minimal glucose or glycerol medium, in low oxygen, by SDS/EDTA (envelope stress) and by H(2)O(2) (PubMed 19734316) (at protein level). {ECO 0000269|PubMed 19121005, ECO 0000269|PubMed 19734316}. # Organism YOHP_ECOLI Escherichia coli (strain K12) # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YOHP_ECOLI Uncharacterized membrane protein YohP # RefSeq WP_000691708 NZ_LN832404.1 # RefSeq YP_002791249 NC_000913.3 # SUBCELLULAR LOCATION YOHP_ECOLI Cell inner membrane {ECO 0000305|PubMed 19121005, ECO 0000305|PubMed 21778229}; Single-pass membrane protein {ECO 0000269|PubMed 19121005, ECO 0000269|PubMed 21778229}. Note=May be able to insert into the membrane in both orientations. Depletion of SecE or YidC does not affect membrane insertion. BLAST swissprot:YOHP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YOHP_ECOLI BioCyc EcoCyc:MONOMER0-2879 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2879 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M111.245696 http://dx.doi.org/10.1074/jbc.M111.245696 DOI 10.1111/j.1365-2958.2008.06495.x http://dx.doi.org/10.1111/j.1365-2958.2008.06495.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00872-09 http://dx.doi.org/10.1128/JB.00872-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14484 http://www.ecogene.org/geneInfo.php?eg_id=EG14484 EnsemblBacteria ACO60001 http://www.ensemblgenomes.org/id/ACO60001 EnsemblBacteria ACO60001 http://www.ensemblgenomes.org/id/ACO60001 EnsemblBacteria b4679 http://www.ensemblgenomes.org/id/b4679 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 7751636 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7751636 KEGG_Gene eco:b4679 http://www.genome.jp/dbget-bin/www_bget?eco:b4679 PSORT swissprot:YOHP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YOHP_ECOLI PSORT-B swissprot:YOHP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YOHP_ECOLI PSORT2 swissprot:YOHP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YOHP_ECOLI Phobius swissprot:YOHP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YOHP_ECOLI PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19121005 http://www.ncbi.nlm.nih.gov/pubmed/19121005 PubMed 19734316 http://www.ncbi.nlm.nih.gov/pubmed/19734316 PubMed 21778229 http://www.ncbi.nlm.nih.gov/pubmed/21778229 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000691708 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000691708 RefSeq YP_002791249 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_002791249 STRING 511145.b4679 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4679&targetmode=cogs UniProtKB YOHP_ECOLI http://www.uniprot.org/uniprot/YOHP_ECOLI UniProtKB-AC C1P609 http://www.uniprot.org/uniprot/C1P609 charge swissprot:YOHP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YOHP_ECOLI epestfind swissprot:YOHP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YOHP_ECOLI garnier swissprot:YOHP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YOHP_ECOLI helixturnhelix swissprot:YOHP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YOHP_ECOLI hmoment swissprot:YOHP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YOHP_ECOLI iep swissprot:YOHP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YOHP_ECOLI inforesidue swissprot:YOHP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YOHP_ECOLI octanol swissprot:YOHP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YOHP_ECOLI pepcoil swissprot:YOHP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YOHP_ECOLI pepdigest swissprot:YOHP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YOHP_ECOLI pepinfo swissprot:YOHP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YOHP_ECOLI pepnet swissprot:YOHP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YOHP_ECOLI pepstats swissprot:YOHP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YOHP_ECOLI pepwheel swissprot:YOHP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YOHP_ECOLI pepwindow swissprot:YOHP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YOHP_ECOLI sigcleave swissprot:YOHP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YOHP_ECOLI ## Database ID URL or Descriptions # BioGrid 4260069 15 # CDD cd03199 GST_C_GRX2 # EcoGene EG12688 grxB # FUNCTION GLRX2_ECOLI Involved in reducing some disulfide bonds in a coupled system with glutathione reductase. Does not act as hydrogen donor for ribonucleotide reductase. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004364 glutathione transferase activity; IBA:GO_Central. # GO_function GO:0009055 electron carrier activity; IEA:InterPro. # GO_function GO:0015038 glutathione disulfide oxidoreductase activity; IDA:EcoCyc. # GO_function GO:0097573 glutathione oxidoreductase activity; IEA:InterPro. # GO_process GO:0006749 glutathione metabolic process; IBA:GO_Central. # GO_process GO:0045454 cell redox homeostasis; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0042592 homeostatic process # Gene3D 1.20.1050.10 -; 1. # Gene3D 3.40.30.10 -; 1. # InterPro IPR004045 Glutathione_S-Trfase_N # InterPro IPR007494 Glutaredoxin2_C # InterPro IPR010987 Glutathione-S-Trfase_C-like # InterPro IPR011767 GLR_AS # InterPro IPR011901 Grx2 # InterPro IPR012336 Thioredoxin-like_fold # KEGG_Brite ko03110 Chaperones and folding catalysts # Organism GLRX2_ECOLI Escherichia coli (strain K12) # PATRIC 32117367 VBIEscCol129921_1106 # PDB 1G7O NMR; -; A=1-215 # PDB 4KSM X-ray; 2.40 A; A=1-215 # PDB 4KX4 X-ray; 1.60 A; A=1-215 # PIR E64849 E64849 # PROSITE PS00195 GLUTAREDOXIN_1 # PROSITE PS50404 GST_NTER # Pfam PF04399 Glutaredoxin2_C # Pfam PF13417 GST_N_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLRX2_ECOLI Glutaredoxin-2 # RefSeq NP_415582 NC_000913.3 # RefSeq WP_000780912 NZ_LN832404.1 # SIMILARITY Belongs to the glutaredoxin family. {ECO 0000305}. # SIMILARITY Contains 1 GST N-terminal domain. {ECO 0000305}. # SUPFAM SSF47616 SSF47616 # SUPFAM SSF52833 SSF52833 # TIGRFAMs TIGR02182 GRXB # eggNOG COG2999 LUCA # eggNOG ENOG4105E9S Bacteria BLAST swissprot:GLRX2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLRX2_ECOLI BioCyc ECOL316407:JW1051-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1051-MONOMER BioCyc EcoCyc:GRXB-MONOMER http://biocyc.org/getid?id=EcoCyc:GRXB-MONOMER BioCyc MetaCyc:GRXB-MONOMER http://biocyc.org/getid?id=MetaCyc:GRXB-MONOMER COG COG2999 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2999 DIP DIP-48247N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48247N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.91.21.9813 http://dx.doi.org/10.1073/pnas.91.21.9813 DOI 10.1074/jbc.272.17.11236 http://dx.doi.org/10.1074/jbc.272.17.11236 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X92076 http://www.ebi.ac.uk/ena/data/view/X92076 EchoBASE EB2551 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2551 EcoGene EG12688 http://www.ecogene.org/geneInfo.php?eg_id=EG12688 EnsemblBacteria AAC74148 http://www.ensemblgenomes.org/id/AAC74148 EnsemblBacteria AAC74148 http://www.ensemblgenomes.org/id/AAC74148 EnsemblBacteria BAA35872 http://www.ensemblgenomes.org/id/BAA35872 EnsemblBacteria BAA35872 http://www.ensemblgenomes.org/id/BAA35872 EnsemblBacteria BAA35872 http://www.ensemblgenomes.org/id/BAA35872 EnsemblBacteria b1064 http://www.ensemblgenomes.org/id/b1064 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004364 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004364 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0015038 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015038 GO_function GO:0097573 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097573 GO_process GO:0006749 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006749 GO_process GO:0045454 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045454 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016765 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 Gene3D 1.20.1050.10 http://www.cathdb.info/version/latest/superfamily/1.20.1050.10 Gene3D 3.40.30.10 http://www.cathdb.info/version/latest/superfamily/3.40.30.10 GeneID 946926 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946926 HOGENOM HOG000064700 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000064700&db=HOGENOM6 InParanoid P0AC59 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AC59 IntAct P0AC59 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AC59* InterPro IPR004045 http://www.ebi.ac.uk/interpro/entry/IPR004045 InterPro IPR007494 http://www.ebi.ac.uk/interpro/entry/IPR007494 InterPro IPR010987 http://www.ebi.ac.uk/interpro/entry/IPR010987 InterPro IPR011767 http://www.ebi.ac.uk/interpro/entry/IPR011767 InterPro IPR011901 http://www.ebi.ac.uk/interpro/entry/IPR011901 InterPro IPR012336 http://www.ebi.ac.uk/interpro/entry/IPR012336 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW1051 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1051 KEGG_Gene eco:b1064 http://www.genome.jp/dbget-bin/www_bget?eco:b1064 KEGG_Orthology KO:K03675 http://www.genome.jp/dbget-bin/www_bget?KO:K03675 OMA LRNLTCV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LRNLTCV PDB 1G7O http://www.ebi.ac.uk/pdbe-srv/view/entry/1G7O PDB 4KSM http://www.ebi.ac.uk/pdbe-srv/view/entry/4KSM PDB 4KX4 http://www.ebi.ac.uk/pdbe-srv/view/entry/4KX4 PDBsum 1G7O http://www.ebi.ac.uk/pdbsum/1G7O PDBsum 4KSM http://www.ebi.ac.uk/pdbsum/4KSM PDBsum 4KX4 http://www.ebi.ac.uk/pdbsum/4KX4 PROSITE PS00195 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00195 PROSITE PS50404 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50404 PSORT swissprot:GLRX2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLRX2_ECOLI PSORT-B swissprot:GLRX2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLRX2_ECOLI PSORT2 swissprot:GLRX2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLRX2_ECOLI Pfam PF04399 http://pfam.xfam.org/family/PF04399 Pfam PF13417 http://pfam.xfam.org/family/PF13417 Phobius swissprot:GLRX2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLRX2_ECOLI ProteinModelPortal P0AC59 http://www.proteinmodelportal.org/query/uniprot/P0AC59 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7937896 http://www.ncbi.nlm.nih.gov/pubmed/7937896 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9111025 http://www.ncbi.nlm.nih.gov/pubmed/9111025 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415582 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415582 RefSeq WP_000780912 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000780912 SMR P0AC59 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AC59 STRING 511145.b1064 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1064&targetmode=cogs STRING COG2999 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2999&targetmode=cogs SUPFAM SSF47616 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47616 SUPFAM SSF52833 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52833 TIGRFAMs TIGR02182 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02182 UniProtKB GLRX2_ECOLI http://www.uniprot.org/uniprot/GLRX2_ECOLI UniProtKB-AC P0AC59 http://www.uniprot.org/uniprot/P0AC59 charge swissprot:GLRX2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLRX2_ECOLI eggNOG COG2999 http://eggnogapi.embl.de/nog_data/html/tree/COG2999 eggNOG ENOG4105E9S http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E9S epestfind swissprot:GLRX2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLRX2_ECOLI garnier swissprot:GLRX2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLRX2_ECOLI helixturnhelix swissprot:GLRX2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLRX2_ECOLI hmoment swissprot:GLRX2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLRX2_ECOLI iep swissprot:GLRX2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLRX2_ECOLI inforesidue swissprot:GLRX2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLRX2_ECOLI octanol swissprot:GLRX2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLRX2_ECOLI pepcoil swissprot:GLRX2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLRX2_ECOLI pepdigest swissprot:GLRX2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLRX2_ECOLI pepinfo swissprot:GLRX2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLRX2_ECOLI pepnet swissprot:GLRX2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLRX2_ECOLI pepstats swissprot:GLRX2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLRX2_ECOLI pepwheel swissprot:GLRX2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLRX2_ECOLI pepwindow swissprot:GLRX2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLRX2_ECOLI sigcleave swissprot:GLRX2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLRX2_ECOLI ## Database ID URL or Descriptions # BioGrid 4262811 20 # EcoGene EG13582 ykgE # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # InterPro IPR004017 Cys_rich_dom # MISCELLANEOUS YKGE_ECOLI The E.coli ykgEFG operon is a clear homolog of the B.subtilis lutABC operon, however it is not able of restoring L- lactate utilization to the B.subtilis mutant for lutABC operon. Thus, ykgEFG operon may contribute to lactate catabolism in E.coli, but under conditions other than those tested, or alternatively, the ykgEFG operon may be responsible for the catabolism of a metabolite other than (but perhaps related to) lactate in E.coli. # Organism YKGE_ECOLI Escherichia coli (strain K12) # PATRIC 32115743 VBIEscCol129921_0314 # PIR B64757 B64757 # Pfam PF02754 CCG; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YKGE_ECOLI Uncharacterized protein YkgE # RefSeq NP_414840 NC_000913.3 # RefSeq WP_001102108 NZ_LN832404.1 # SIMILARITY Belongs to the LutA/YkgE family. {ECO 0000305}. # eggNOG COG0247 LUCA # eggNOG ENOG4105CHG Bacteria BLAST swissprot:YKGE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YKGE_ECOLI BioCyc ECOL316407:JW5041-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5041-MONOMER BioCyc EcoCyc:G6176-MONOMER http://biocyc.org/getid?id=EcoCyc:G6176-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01464-08 http://dx.doi.org/10.1128/JB.01464-08 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB3352 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3352 EcoGene EG13582 http://www.ecogene.org/geneInfo.php?eg_id=EG13582 EnsemblBacteria AAC73409 http://www.ensemblgenomes.org/id/AAC73409 EnsemblBacteria AAC73409 http://www.ensemblgenomes.org/id/AAC73409 EnsemblBacteria BAE76090 http://www.ensemblgenomes.org/id/BAE76090 EnsemblBacteria BAE76090 http://www.ensemblgenomes.org/id/BAE76090 EnsemblBacteria BAE76090 http://www.ensemblgenomes.org/id/BAE76090 EnsemblBacteria b0306 http://www.ensemblgenomes.org/id/b0306 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GeneID 948438 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948438 HOGENOM HOG000262113 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000262113&db=HOGENOM6 InParanoid P77252 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77252 InterPro IPR004017 http://www.ebi.ac.uk/interpro/entry/IPR004017 KEGG_Gene ecj:JW5041 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5041 KEGG_Gene eco:b0306 http://www.genome.jp/dbget-bin/www_bget?eco:b0306 OMA NSCLMHI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NSCLMHI PSORT swissprot:YKGE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YKGE_ECOLI PSORT-B swissprot:YKGE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YKGE_ECOLI PSORT2 swissprot:YKGE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YKGE_ECOLI Pfam PF02754 http://pfam.xfam.org/family/PF02754 Phobius swissprot:YKGE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YKGE_ECOLI PhylomeDB P77252 http://phylomedb.org/?seqid=P77252 ProteinModelPortal P77252 http://www.proteinmodelportal.org/query/uniprot/P77252 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19201793 http://www.ncbi.nlm.nih.gov/pubmed/19201793 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414840 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414840 RefSeq WP_001102108 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001102108 SMR P77252 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77252 STRING 511145.b0306 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0306&targetmode=cogs UniProtKB YKGE_ECOLI http://www.uniprot.org/uniprot/YKGE_ECOLI UniProtKB-AC P77252 http://www.uniprot.org/uniprot/P77252 charge swissprot:YKGE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YKGE_ECOLI eggNOG COG0247 http://eggnogapi.embl.de/nog_data/html/tree/COG0247 eggNOG ENOG4105CHG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CHG epestfind swissprot:YKGE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YKGE_ECOLI garnier swissprot:YKGE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YKGE_ECOLI helixturnhelix swissprot:YKGE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YKGE_ECOLI hmoment swissprot:YKGE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YKGE_ECOLI iep swissprot:YKGE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YKGE_ECOLI inforesidue swissprot:YKGE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YKGE_ECOLI octanol swissprot:YKGE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YKGE_ECOLI pepcoil swissprot:YKGE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YKGE_ECOLI pepdigest swissprot:YKGE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YKGE_ECOLI pepinfo swissprot:YKGE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YKGE_ECOLI pepnet swissprot:YKGE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YKGE_ECOLI pepstats swissprot:YKGE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YKGE_ECOLI pepwheel swissprot:YKGE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YKGE_ECOLI pepwindow swissprot:YKGE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YKGE_ECOLI sigcleave swissprot:YKGE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YKGE_ECOLI ## Database ID URL or Descriptions # AltName ATPG_ECOLI ATP synthase F1 sector gamma subunit # AltName ATPG_ECOLI F-ATPase gamma subunit # CDD cd12151 F1-ATPase_gamma # EcoGene EG10104 atpG # FUNCTION ATPG_ECOLI Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_component GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1); IMP:EcoliWiki. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0046933 proton-transporting ATP synthase activity, rotational mechanism; IDA:EcoCyc. # GO_function GO:0046961 proton-transporting ATPase activity, rotational mechanism; IDA:EcoCyc. # GO_process GO:0042777 plasma membrane ATP synthesis coupled proton transport; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0055085 transmembrane transport # HAMAP MF_00815 ATP_synth_gamma_bact # INTERACTION ATPG_ECOLI P0A6E6 atpC; NbExp=4; IntAct=EBI-544306, EBI-544362; # IntAct P0ABA6 15 # InterPro IPR000131 ATP_synth_F1_gsu # InterPro IPR023632 ATP_synth_F1_gsu_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko00194 Photosynthesis proteins # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00190 Oxidative phosphorylation # KEGG_Pathway ko00195 Photosynthesis # Organism ATPG_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11693 PTHR11693 # PATRIC 32122963 VBIEscCol129921_3857 # PDB 1D8S X-ray; 4.40 A; G=1-287 # PDB 1FS0 X-ray; 2.10 A; G=19-248 # PDB 3OAA X-ray; 3.26 A; G/O/W/e=2-287 # PIR A01038 PWECG # PRINTS PR00126 ATPASEGAMMA # PROSITE PS00153 ATPASE_GAMMA # Pfam PF00231 ATP-synt # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ATPG_ECOLI ATP synthase gamma chain # RefSeq NP_418189 NC_000913.3 # RefSeq WP_000896498 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA23597.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=CAA23597.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ATPase gamma chain family. {ECO 0000305}. # SUBCELLULAR LOCATION ATPG_ECOLI Cell inner membrane {ECO 0000269|PubMed 16079137}; Peripheral membrane protein {ECO 0000269|PubMed 16079137}. # SUBUNIT ATPG_ECOLI F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits a, b and c. {ECO 0000269|PubMed 16079137}. # SUPFAM SSF52943 SSF52943 # TCDB 3.A.2.1 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily # TIGRFAMs TIGR01146 ATPsyn_F1gamma # eggNOG COG0224 LUCA # eggNOG ENOG4105J80 Bacteria BLAST swissprot:ATPG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ATPG_ECOLI BioCyc ECOL316407:JW3711-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3711-MONOMER BioCyc EcoCyc:ATPG-MONOMER http://biocyc.org/getid?id=EcoCyc:ATPG-MONOMER BioCyc MetaCyc:ATPG-MONOMER http://biocyc.org/getid?id=MetaCyc:ATPG-MONOMER COG COG0224 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0224 DIP DIP-35938N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35938N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1016/0006-291X(81)90494-0 http://dx.doi.org/10.1016/0006-291X(81)90494-0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2240799 http://dx.doi.org/10.1042/bj2240799 DOI 10.1073/pnas.96.24.13697 http://dx.doi.org/10.1073/pnas.96.24.13697 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1093/nar/9.20.5287 http://dx.doi.org/10.1093/nar/9.20.5287 DOI 10.1111/j.1749-6632.1982.tb25731.x http://dx.doi.org/10.1111/j.1749-6632.1982.tb25731.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01594 http://www.ebi.ac.uk/ena/data/view/J01594 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M25464 http://www.ebi.ac.uk/ena/data/view/M25464 EMBL M34095 http://www.ebi.ac.uk/ena/data/view/M34095 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00267 http://www.ebi.ac.uk/ena/data/view/V00267 EMBL V00312 http://www.ebi.ac.uk/ena/data/view/V00312 EMBL X01631 http://www.ebi.ac.uk/ena/data/view/X01631 EchoBASE EB0102 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0102 EcoGene EG10104 http://www.ecogene.org/geneInfo.php?eg_id=EG10104 EnsemblBacteria AAC76756 http://www.ensemblgenomes.org/id/AAC76756 EnsemblBacteria AAC76756 http://www.ensemblgenomes.org/id/AAC76756 EnsemblBacteria BAE77555 http://www.ensemblgenomes.org/id/BAE77555 EnsemblBacteria BAE77555 http://www.ensemblgenomes.org/id/BAE77555 EnsemblBacteria BAE77555 http://www.ensemblgenomes.org/id/BAE77555 EnsemblBacteria b3733 http://www.ensemblgenomes.org/id/b3733 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0045261 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045261 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0046933 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046933 GO_function GO:0046961 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046961 GO_process GO:0042777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042777 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 948243 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948243 HAMAP MF_00815 http://hamap.expasy.org/unirule/MF_00815 HOGENOM HOG000215912 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000215912&db=HOGENOM6 InParanoid P0ABA6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABA6 IntAct P0ABA6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABA6* InterPro IPR000131 http://www.ebi.ac.uk/interpro/entry/IPR000131 InterPro IPR023632 http://www.ebi.ac.uk/interpro/entry/IPR023632 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko00194 http://www.genome.jp/dbget-bin/www_bget?ko00194 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3711 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3711 KEGG_Gene eco:b3733 http://www.genome.jp/dbget-bin/www_bget?eco:b3733 KEGG_Orthology KO:K02115 http://www.genome.jp/dbget-bin/www_bget?KO:K02115 KEGG_Pathway ko00190 http://www.genome.jp/kegg-bin/show_pathway?ko00190 KEGG_Pathway ko00195 http://www.genome.jp/kegg-bin/show_pathway?ko00195 OMA DRGMCGG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DRGMCGG PANTHER PTHR11693 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11693 PDB 1D8S http://www.ebi.ac.uk/pdbe-srv/view/entry/1D8S PDB 1FS0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1FS0 PDB 3OAA http://www.ebi.ac.uk/pdbe-srv/view/entry/3OAA PDBsum 1D8S http://www.ebi.ac.uk/pdbsum/1D8S PDBsum 1FS0 http://www.ebi.ac.uk/pdbsum/1FS0 PDBsum 3OAA http://www.ebi.ac.uk/pdbsum/3OAA PRINTS PR00126 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00126 PROSITE PS00153 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00153 PSORT swissprot:ATPG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ATPG_ECOLI PSORT-B swissprot:ATPG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ATPG_ECOLI PSORT2 swissprot:ATPG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ATPG_ECOLI Pfam PF00231 http://pfam.xfam.org/family/PF00231 Phobius swissprot:ATPG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ATPG_ECOLI PhylomeDB P0ABA6 http://phylomedb.org/?seqid=P0ABA6 ProteinModelPortal P0ABA6 http://www.proteinmodelportal.org/query/uniprot/P0ABA6 PubMed 10570135 http://www.ncbi.nlm.nih.gov/pubmed/10570135 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2138624 http://www.ncbi.nlm.nih.gov/pubmed/2138624 PubMed 6272217 http://www.ncbi.nlm.nih.gov/pubmed/6272217 PubMed 6277310 http://www.ncbi.nlm.nih.gov/pubmed/6277310 PubMed 6301339 http://www.ncbi.nlm.nih.gov/pubmed/6301339 PubMed 6395859 http://www.ncbi.nlm.nih.gov/pubmed/6395859 PubMed 7508444 http://www.ncbi.nlm.nih.gov/pubmed/7508444 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418189 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418189 RefSeq WP_000896498 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000896498 SMR P0ABA6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABA6 STRING 511145.b3733 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3733&targetmode=cogs STRING COG0224 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0224&targetmode=cogs SUPFAM SSF52943 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52943 TCDB 3.A.2.1 http://www.tcdb.org/search/result.php?tc=3.A.2.1 TIGRFAMs TIGR01146 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01146 UniProtKB ATPG_ECOLI http://www.uniprot.org/uniprot/ATPG_ECOLI UniProtKB-AC P0ABA6 http://www.uniprot.org/uniprot/P0ABA6 charge swissprot:ATPG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ATPG_ECOLI eggNOG COG0224 http://eggnogapi.embl.de/nog_data/html/tree/COG0224 eggNOG ENOG4105J80 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105J80 epestfind swissprot:ATPG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ATPG_ECOLI garnier swissprot:ATPG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ATPG_ECOLI helixturnhelix swissprot:ATPG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ATPG_ECOLI hmoment swissprot:ATPG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ATPG_ECOLI iep swissprot:ATPG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ATPG_ECOLI inforesidue swissprot:ATPG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ATPG_ECOLI octanol swissprot:ATPG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ATPG_ECOLI pepcoil swissprot:ATPG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ATPG_ECOLI pepdigest swissprot:ATPG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ATPG_ECOLI pepinfo swissprot:ATPG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ATPG_ECOLI pepnet swissprot:ATPG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ATPG_ECOLI pepstats swissprot:ATPG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ATPG_ECOLI pepwheel swissprot:ATPG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ATPG_ECOLI pepwindow swissprot:ATPG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ATPG_ECOLI sigcleave swissprot:ATPG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ATPG_ECOLI ## Database ID URL or Descriptions # Organism YUAX_ECOLI Escherichia coli (strain K12) # RecName YUAX_ECOLI Uncharacterized protein YuaX # RefSeq NP_061417 NC_002483.1 # RefSeq WP_000538310 NZ_CP014273.1 BLAST swissprot:YUAX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YUAX_ECOLI EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1263504 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263504 OMA ATEFRIK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ATEFRIK PSORT swissprot:YUAX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YUAX_ECOLI PSORT-B swissprot:YUAX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YUAX_ECOLI PSORT2 swissprot:YUAX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YUAX_ECOLI Phobius swissprot:YUAX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YUAX_ECOLI ProteinModelPortal Q9JMR7 http://www.proteinmodelportal.org/query/uniprot/Q9JMR7 RefSeq NP_061417 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061417 RefSeq WP_000538310 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000538310 UniProtKB YUAX_ECOLI http://www.uniprot.org/uniprot/YUAX_ECOLI UniProtKB-AC Q9JMR7 http://www.uniprot.org/uniprot/Q9JMR7 charge swissprot:YUAX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YUAX_ECOLI epestfind swissprot:YUAX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YUAX_ECOLI garnier swissprot:YUAX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YUAX_ECOLI helixturnhelix swissprot:YUAX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YUAX_ECOLI hmoment swissprot:YUAX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YUAX_ECOLI iep swissprot:YUAX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YUAX_ECOLI inforesidue swissprot:YUAX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YUAX_ECOLI octanol swissprot:YUAX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YUAX_ECOLI pepcoil swissprot:YUAX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YUAX_ECOLI pepdigest swissprot:YUAX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YUAX_ECOLI pepinfo swissprot:YUAX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YUAX_ECOLI pepnet swissprot:YUAX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YUAX_ECOLI pepstats swissprot:YUAX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YUAX_ECOLI pepwheel swissprot:YUAX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YUAX_ECOLI pepwindow swissprot:YUAX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YUAX_ECOLI sigcleave swissprot:YUAX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YUAX_ECOLI ## Database ID URL or Descriptions # AltName ARGB_ECOLI N-acetyl-L-glutamate 5-phosphotransferase # AltName ARGB_ECOLI NAG kinase # BRENDA 2.7.2 2026 # BioGrid 4261889 6 # CATALYTIC ACTIVITY ARGB_ECOLI ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L- glutamate 5-phosphate. # EcoGene EG10064 argB # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003991 acetylglutamate kinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0034618 arginine binding; IBA:GO_Central. # GO_process GO:0006526 arginine biosynthetic process; IDA:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.1160.10 -; 1. # HAMAP MF_00082_B ArgB_B # IntAct P0A6C8 2 # InterPro IPR001048 Asp/Glu/Uridylate_kinase # InterPro IPR004662 AcgluKinase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00330 Arginine and proline metabolism # Organism ARGB_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-arginine biosynthesis; N(2)- acetyl-L-ornithine from L-glutamate step 2/4. # PATRIC 32123439 VBIEscCol129921_4080 # PDB 1GS5 X-ray; 1.50 A; A=1-258 # PDB 1GSJ X-ray; 1.85 A; A=1-258 # PDB 1OH9 X-ray; 1.91 A; A=1-258 # PDB 1OHA X-ray; 1.90 A; A=1-258 # PDB 1OHB X-ray; 1.90 A; A=1-258 # PDB 2WXB X-ray; 2.00 A; A/B=1-258 # PDB 2X2W X-ray; 2.00 A; A/B=1-258 # PIR JT0331 KIECAE # PIRSF PIRSF000728 NAGK # Pfam PF00696 AA_kinase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ARGB_ECOLI Acetylglutamate kinase # RefSeq NP_418394 NC_000913.3 # SEQUENCE CAUTION Sequence=BAE77352.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the acetylglutamate kinase family. {ECO 0000305}. # SUBCELLULAR LOCATION ARGB_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT ARGB_ECOLI Homodimer. {ECO 0000269|PubMed 12005432, ECO 0000269|PubMed 12875848}. # SUPFAM SSF53633 SSF53633 # TIGRFAMs TIGR00761 argB # UniPathway UPA00068 UER00107 # eggNOG COG0548 LUCA # eggNOG ENOG4105CAS Bacteria BLAST swissprot:ARGB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARGB_ECOLI BioCyc ECOL316407:JW5553-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5553-MONOMER BioCyc EcoCyc:ACETYLGLUTKIN-MONOMER http://biocyc.org/getid?id=EcoCyc:ACETYLGLUTKIN-MONOMER BioCyc MetaCyc:ACETYLGLUTKIN-MONOMER http://biocyc.org/getid?id=MetaCyc:ACETYLGLUTKIN-MONOMER COG COG0548 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0548 DIP DIP-9136N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9136N DOI 10.1016/0378-1119(88)90030-3 http://dx.doi.org/10.1016/0378-1119(88)90030-3 DOI 10.1016/S0022-2836(03)00716-2 http://dx.doi.org/10.1016/S0022-2836(03)00716-2 DOI 10.1016/S0969-2126(02)00721-9 http://dx.doi.org/10.1016/S0969-2126(02)00721-9 DOI 10.1016/j.jmb.2003.09.038 http://dx.doi.org/10.1016/j.jmb.2003.09.038 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1107/S0907444999005351 http://dx.doi.org/10.1107/S0907444999005351 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.2.8 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.2.8 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M21446 http://www.ebi.ac.uk/ena/data/view/M21446 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.2.8 http://enzyme.expasy.org/EC/2.7.2.8 EchoBASE EB0062 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0062 EcoGene EG10064 http://www.ecogene.org/geneInfo.php?eg_id=EG10064 EnsemblBacteria AAC76941 http://www.ensemblgenomes.org/id/AAC76941 EnsemblBacteria AAC76941 http://www.ensemblgenomes.org/id/AAC76941 EnsemblBacteria BAE77352 http://www.ensemblgenomes.org/id/BAE77352 EnsemblBacteria BAE77352 http://www.ensemblgenomes.org/id/BAE77352 EnsemblBacteria BAE77352 http://www.ensemblgenomes.org/id/BAE77352 EnsemblBacteria b3959 http://www.ensemblgenomes.org/id/b3959 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003991 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003991 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0034618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034618 GO_process GO:0006526 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006526 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.1160.10 http://www.cathdb.info/version/latest/superfamily/3.40.1160.10 GeneID 948464 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948464 HAMAP MF_00082_B http://hamap.expasy.org/unirule/MF_00082_B HOGENOM HOG000233260 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000233260&db=HOGENOM6 InParanoid P0A6C8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6C8 IntAct P0A6C8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6C8* IntEnz 2.7.2.8 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.2.8 InterPro IPR001048 http://www.ebi.ac.uk/interpro/entry/IPR001048 InterPro IPR004662 http://www.ebi.ac.uk/interpro/entry/IPR004662 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5553 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5553 KEGG_Gene eco:b3959 http://www.genome.jp/dbget-bin/www_bget?eco:b3959 KEGG_Orthology KO:K00930 http://www.genome.jp/dbget-bin/www_bget?KO:K00930 KEGG_Pathway ko00330 http://www.genome.jp/kegg-bin/show_pathway?ko00330 KEGG_Reaction rn:R02649 http://www.genome.jp/dbget-bin/www_bget?rn:R02649 MINT MINT-1309378 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1309378 OMA LVHGGGC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LVHGGGC PDB 1GS5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1GS5 PDB 1GSJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1GSJ PDB 1OH9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1OH9 PDB 1OHA http://www.ebi.ac.uk/pdbe-srv/view/entry/1OHA PDB 1OHB http://www.ebi.ac.uk/pdbe-srv/view/entry/1OHB PDB 2WXB http://www.ebi.ac.uk/pdbe-srv/view/entry/2WXB PDB 2X2W http://www.ebi.ac.uk/pdbe-srv/view/entry/2X2W PDBsum 1GS5 http://www.ebi.ac.uk/pdbsum/1GS5 PDBsum 1GSJ http://www.ebi.ac.uk/pdbsum/1GSJ PDBsum 1OH9 http://www.ebi.ac.uk/pdbsum/1OH9 PDBsum 1OHA http://www.ebi.ac.uk/pdbsum/1OHA PDBsum 1OHB http://www.ebi.ac.uk/pdbsum/1OHB PDBsum 2WXB http://www.ebi.ac.uk/pdbsum/2WXB PDBsum 2X2W http://www.ebi.ac.uk/pdbsum/2X2W PSORT swissprot:ARGB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARGB_ECOLI PSORT-B swissprot:ARGB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARGB_ECOLI PSORT2 swissprot:ARGB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARGB_ECOLI Pfam PF00696 http://pfam.xfam.org/family/PF00696 Phobius swissprot:ARGB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARGB_ECOLI PhylomeDB P0A6C8 http://phylomedb.org/?seqid=P0A6C8 ProteinModelPortal P0A6C8 http://www.proteinmodelportal.org/query/uniprot/P0A6C8 PubMed 10393305 http://www.ncbi.nlm.nih.gov/pubmed/10393305 PubMed 12005432 http://www.ncbi.nlm.nih.gov/pubmed/12005432 PubMed 12875848 http://www.ncbi.nlm.nih.gov/pubmed/12875848 PubMed 14623187 http://www.ncbi.nlm.nih.gov/pubmed/14623187 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2851495 http://www.ncbi.nlm.nih.gov/pubmed/2851495 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418394 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418394 SMR P0A6C8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6C8 STRING 511145.b3959 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3959&targetmode=cogs STRING COG0548 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0548&targetmode=cogs SUPFAM SSF53633 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53633 TIGRFAMs TIGR00761 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00761 UniProtKB ARGB_ECOLI http://www.uniprot.org/uniprot/ARGB_ECOLI UniProtKB-AC P0A6C8 http://www.uniprot.org/uniprot/P0A6C8 charge swissprot:ARGB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARGB_ECOLI eggNOG COG0548 http://eggnogapi.embl.de/nog_data/html/tree/COG0548 eggNOG ENOG4105CAS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CAS epestfind swissprot:ARGB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARGB_ECOLI garnier swissprot:ARGB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARGB_ECOLI helixturnhelix swissprot:ARGB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARGB_ECOLI hmoment swissprot:ARGB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARGB_ECOLI iep swissprot:ARGB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARGB_ECOLI inforesidue swissprot:ARGB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARGB_ECOLI octanol swissprot:ARGB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARGB_ECOLI pepcoil swissprot:ARGB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARGB_ECOLI pepdigest swissprot:ARGB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARGB_ECOLI pepinfo swissprot:ARGB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARGB_ECOLI pepnet swissprot:ARGB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARGB_ECOLI pepstats swissprot:ARGB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARGB_ECOLI pepwheel swissprot:ARGB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARGB_ECOLI pepwindow swissprot:ARGB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARGB_ECOLI sigcleave swissprot:ARGB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARGB_ECOLI ## Database ID URL or Descriptions # BioGrid 4259942 11 # COFACTOR Name=heme; Xref=ChEBI:CHEBI 30413; Note=The heme is bound between the two transmembrane subunits.; # EcoGene EG10933 sdhC # FUNCTION DHSC_ECOLI Membrane-anchoring subunit of succinate dehydrogenase (SDH). # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_component GO:0045281 succinate dehydrogenase complex; IEA:InterPro. # GO_function GO:0008177 succinate dehydrogenase (ubiquinone) activity; IMP:EcoliWiki. # GO_function GO:0009055 electron carrier activity; IDA:EcoCyc. # GO_function GO:0020037 heme binding; IMP:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0048039 ubiquinone binding; IDA:EcoliWiki. # GO_process GO:0006099 tricarboxylic acid cycle; IEA:UniProtKB-UniPathway. # GO_process GO:0009060 aerobic respiration; IEP:EcoCyc. # GO_process GO:0017004 cytochrome complex assembly; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0044281 small molecule metabolic process # IntAct P69054 4 # InterPro IPR000701 Succ_DH_Fumarate_Rdtase_TM-su # InterPro IPR014314 Succ_DH_cytb556 # InterPro IPR018495 Succ_DH_cyt_bsu_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Pathway ko00020 Citrate cycle (TCA cycle) # KEGG_Pathway ko00190 Oxidative phosphorylation # KEGG_Pathway ko00623 Toluene degradation # KEGG_Pathway ko00650 Butanoate metabolism # KEGG_Pathway ko00720 Carbon fixation pathways in prokaryotes # MISCELLANEOUS DHSC_ECOLI His-84 provides an axial ligand to heme b556 in the wild-type enzyme. The retention of low spin heme b556 in the SdhC 'Leu-84' mutant suggests that swapping of the heme axial ligand by His-91 or His-30 is possible. # Organism DHSC_ECOLI Escherichia coli (strain K12) # PATHWAY DHSC_ECOLI Carbohydrate metabolism; tricarboxylic acid cycle. # PATRIC 32116637 VBIEscCol129921_0751 # PDB 1NEK X-ray; 2.60 A; C=1-129 # PDB 1NEN X-ray; 2.90 A; C=1-129 # PDB 2ACZ X-ray; 3.10 A; C=1-129 # PDB 2AD0 Model; -; C=1-129 # PDB 2WDQ X-ray; 2.40 A; C/G/K=1-129 # PDB 2WDR X-ray; 3.20 A; C/G/K=1-129 # PDB 2WDV X-ray; 3.20 A; C/G/K=1-129 # PDB 2WP9 X-ray; 2.70 A; C/G/K=1-129 # PDB 2WS3 X-ray; 3.20 A; C/G/K=1-129 # PDB 2WU2 X-ray; 2.50 A; C/G/K=1-129 # PDB 2WU5 X-ray; 2.80 A; C/G/K=1-129 # PIR A28836 DEECS4 # PROSITE PS01000 SDH_CYT_1 # PROSITE PS01001 SDH_CYT_2 # Pfam PF01127 Sdh_cyt # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DHSC_ECOLI Succinate dehydrogenase cytochrome b556 subunit # RefSeq NP_415249 NC_000913.3 # SIMILARITY Belongs to the cytochrome b560 family. {ECO 0000305}. # SUBCELLULAR LOCATION DHSC_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT DHSC_ECOLI Part of an enzyme complex containing four subunits a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD. The complex can form homotrimers. {ECO 0000269|PubMed 12560550, ECO 0000269|PubMed 16407191, ECO 0000269|PubMed 19710024}. # TIGRFAMs TIGR02970 succ_dehyd_cytB # eggNOG COG2009 LUCA # eggNOG ENOG4108UTY Bacteria BLAST swissprot:DHSC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DHSC_ECOLI BioCyc ECOL316407:JW0711-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0711-MONOMER BioCyc EcoCyc:SDH-MEMB1 http://biocyc.org/getid?id=EcoCyc:SDH-MEMB1 BioCyc MetaCyc:SDH-MEMB1 http://biocyc.org/getid?id=MetaCyc:SDH-MEMB1 COG COG2009 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2009 DIP DIP-10837N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10837N DOI 10.1021/bi9716635 http://dx.doi.org/10.1021/bi9716635 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2220519 http://dx.doi.org/10.1042/bj2220519 DOI 10.1074/jbc.273.48.31916 http://dx.doi.org/10.1074/jbc.273.48.31916 DOI 10.1074/jbc.M011270200 http://dx.doi.org/10.1074/jbc.M011270200 DOI 10.1074/jbc.M109.010058 http://dx.doi.org/10.1074/jbc.M109.010058 DOI 10.1074/jbc.M508173200 http://dx.doi.org/10.1074/jbc.M508173200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1099/00221287-132-12-3239 http://dx.doi.org/10.1099/00221287-132-12-3239 DOI 10.1126/science.1079605 http://dx.doi.org/10.1126/science.1079605 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01619 http://www.ebi.ac.uk/ena/data/view/J01619 EMBL M28989 http://www.ebi.ac.uk/ena/data/view/M28989 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X00980 http://www.ebi.ac.uk/ena/data/view/X00980 EchoBASE EB0926 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0926 EcoGene EG10933 http://www.ecogene.org/geneInfo.php?eg_id=EG10933 EnsemblBacteria AAC73815 http://www.ensemblgenomes.org/id/AAC73815 EnsemblBacteria AAC73815 http://www.ensemblgenomes.org/id/AAC73815 EnsemblBacteria BAA35388 http://www.ensemblgenomes.org/id/BAA35388 EnsemblBacteria BAA35388 http://www.ensemblgenomes.org/id/BAA35388 EnsemblBacteria BAA35388 http://www.ensemblgenomes.org/id/BAA35388 EnsemblBacteria b0721 http://www.ensemblgenomes.org/id/b0721 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0045281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045281 GO_function GO:0008177 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008177 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0020037 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0020037 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0048039 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048039 GO_process GO:0006099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006099 GO_process GO:0009060 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009060 GO_process GO:0017004 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017004 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 945316 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945316 HOGENOM HOG000160252 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000160252&db=HOGENOM6 InParanoid P69054 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P69054 IntAct P69054 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69054* InterPro IPR000701 http://www.ebi.ac.uk/interpro/entry/IPR000701 InterPro IPR014314 http://www.ebi.ac.uk/interpro/entry/IPR014314 InterPro IPR018495 http://www.ebi.ac.uk/interpro/entry/IPR018495 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Gene ecj:JW0711 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0711 KEGG_Gene eco:b0721 http://www.genome.jp/dbget-bin/www_bget?eco:b0721 KEGG_Orthology KO:K00241 http://www.genome.jp/dbget-bin/www_bget?KO:K00241 KEGG_Pathway ko00020 http://www.genome.jp/kegg-bin/show_pathway?ko00020 KEGG_Pathway ko00190 http://www.genome.jp/kegg-bin/show_pathway?ko00190 KEGG_Pathway ko00623 http://www.genome.jp/kegg-bin/show_pathway?ko00623 KEGG_Pathway ko00650 http://www.genome.jp/kegg-bin/show_pathway?ko00650 KEGG_Pathway ko00720 http://www.genome.jp/kegg-bin/show_pathway?ko00720 KEGG_Reaction rn:R00408 http://www.genome.jp/dbget-bin/www_bget?rn:R00408 KEGG_Reaction rn:R00412 http://www.genome.jp/dbget-bin/www_bget?rn:R00412 OMA IVKFIVW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IVKFIVW PDB 1NEK http://www.ebi.ac.uk/pdbe-srv/view/entry/1NEK PDB 1NEN http://www.ebi.ac.uk/pdbe-srv/view/entry/1NEN PDB 2ACZ http://www.ebi.ac.uk/pdbe-srv/view/entry/2ACZ PDB 2AD0 http://www.ebi.ac.uk/pdbe-srv/view/entry/2AD0 PDB 2WDQ http://www.ebi.ac.uk/pdbe-srv/view/entry/2WDQ PDB 2WDR http://www.ebi.ac.uk/pdbe-srv/view/entry/2WDR PDB 2WDV http://www.ebi.ac.uk/pdbe-srv/view/entry/2WDV PDB 2WP9 http://www.ebi.ac.uk/pdbe-srv/view/entry/2WP9 PDB 2WS3 http://www.ebi.ac.uk/pdbe-srv/view/entry/2WS3 PDB 2WU2 http://www.ebi.ac.uk/pdbe-srv/view/entry/2WU2 PDB 2WU5 http://www.ebi.ac.uk/pdbe-srv/view/entry/2WU5 PDBsum 1NEK http://www.ebi.ac.uk/pdbsum/1NEK PDBsum 1NEN http://www.ebi.ac.uk/pdbsum/1NEN PDBsum 2ACZ http://www.ebi.ac.uk/pdbsum/2ACZ PDBsum 2AD0 http://www.ebi.ac.uk/pdbsum/2AD0 PDBsum 2WDQ http://www.ebi.ac.uk/pdbsum/2WDQ PDBsum 2WDR http://www.ebi.ac.uk/pdbsum/2WDR PDBsum 2WDV http://www.ebi.ac.uk/pdbsum/2WDV PDBsum 2WP9 http://www.ebi.ac.uk/pdbsum/2WP9 PDBsum 2WS3 http://www.ebi.ac.uk/pdbsum/2WS3 PDBsum 2WU2 http://www.ebi.ac.uk/pdbsum/2WU2 PDBsum 2WU5 http://www.ebi.ac.uk/pdbsum/2WU5 PROSITE PS01000 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01000 PROSITE PS01001 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01001 PSORT swissprot:DHSC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DHSC_ECOLI PSORT-B swissprot:DHSC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DHSC_ECOLI PSORT2 swissprot:DHSC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DHSC_ECOLI Pfam PF01127 http://pfam.xfam.org/family/PF01127 Phobius swissprot:DHSC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DHSC_ECOLI PhylomeDB P69054 http://phylomedb.org/?seqid=P69054 ProteinModelPortal P69054 http://www.proteinmodelportal.org/query/uniprot/P69054 PubMed 11259408 http://www.ncbi.nlm.nih.gov/pubmed/11259408 PubMed 12560550 http://www.ncbi.nlm.nih.gov/pubmed/12560550 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16407191 http://www.ncbi.nlm.nih.gov/pubmed/16407191 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19710024 http://www.ncbi.nlm.nih.gov/pubmed/19710024 PubMed 3309132 http://www.ncbi.nlm.nih.gov/pubmed/3309132 PubMed 6383359 http://www.ncbi.nlm.nih.gov/pubmed/6383359 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9521736 http://www.ncbi.nlm.nih.gov/pubmed/9521736 PubMed 9822661 http://www.ncbi.nlm.nih.gov/pubmed/9822661 RefSeq NP_415249 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415249 SMR P69054 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69054 STRING 511145.b0721 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0721&targetmode=cogs STRING COG2009 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2009&targetmode=cogs TIGRFAMs TIGR02970 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02970 UniProtKB DHSC_ECOLI http://www.uniprot.org/uniprot/DHSC_ECOLI UniProtKB-AC P69054 http://www.uniprot.org/uniprot/P69054 charge swissprot:DHSC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DHSC_ECOLI eggNOG COG2009 http://eggnogapi.embl.de/nog_data/html/tree/COG2009 eggNOG ENOG4108UTY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UTY epestfind swissprot:DHSC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DHSC_ECOLI garnier swissprot:DHSC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DHSC_ECOLI helixturnhelix swissprot:DHSC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DHSC_ECOLI hmoment swissprot:DHSC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DHSC_ECOLI iep swissprot:DHSC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DHSC_ECOLI inforesidue swissprot:DHSC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DHSC_ECOLI octanol swissprot:DHSC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DHSC_ECOLI pepcoil swissprot:DHSC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DHSC_ECOLI pepdigest swissprot:DHSC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DHSC_ECOLI pepinfo swissprot:DHSC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DHSC_ECOLI pepnet swissprot:DHSC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DHSC_ECOLI pepstats swissprot:DHSC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DHSC_ECOLI pepwheel swissprot:DHSC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DHSC_ECOLI pepwindow swissprot:DHSC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DHSC_ECOLI sigcleave swissprot:DHSC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DHSC_ECOLI ## Database ID URL or Descriptions # BioGrid 4262401 7 # EcoGene EG12724 higA # FUNCTION HIGA_ECOLI Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin; overexpression prevents HigB-mediated cessation of cell growth and inhibition of cell proliferation. {ECO 0000269|PubMed 19943910}. # GO_function GO:0043565 sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IMP:EcoCyc. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.260.40 -; 1. # INDUCTION Induced by amino acid starvation and when translation is blocked. Induction is decreased in the absence of the Lon protease suggesting, by homology to other toxin-antitoxin systems, that Lon may degrade the HigA antitoxin. Transcription is negatively regulated by the cognate locus, probably by this protein. A member of the higB-higA operon. {ECO:0000269|PubMed 19943910}. # IntAct P67701 13 # InterPro IPR001387 Cro/C1-type_HTH # InterPro IPR010982 Lambda_DNA-bd_dom # Organism HIGA_ECOLI Escherichia coli (strain K12) # PATRIC 32121582 VBIEscCol129921_3177 # PIR G65096 G65096 # PROSITE PS50943 HTH_CROC1 # Pfam PF01381 HTH_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HIGA_ECOLI Antitoxin HigA # RefSeq NP_417553 NC_000913.3 # RefSeq WP_000560266 NZ_LN832404.1 # SIMILARITY Belongs to the HigA antitoxin family. {ECO 0000305}. # SIMILARITY Contains 1 HTH cro/C1-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00257}. # SMART SM00530 HTH_XRE # SUBUNIT Probably forms a complex with the mRNA interferase HigB which inhibits the mRNA interferase activity. {ECO 0000305}. # SUPFAM SSF47413 SSF47413 # eggNOG COG5499 LUCA # eggNOG ENOG4108Z3N Bacteria BLAST swissprot:HIGA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HIGA_ECOLI BioCyc ECOL316407:JW3053-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3053-MONOMER BioCyc EcoCyc:G7601-MONOMER http://biocyc.org/getid?id=EcoCyc:G7601-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2009.06969.x http://dx.doi.org/10.1111/j.1365-2958.2009.06969.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2583 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2583 EcoGene EG12724 http://www.ecogene.org/geneInfo.php?eg_id=EG12724 EnsemblBacteria AAC76117 http://www.ensemblgenomes.org/id/AAC76117 EnsemblBacteria AAC76117 http://www.ensemblgenomes.org/id/AAC76117 EnsemblBacteria BAE77132 http://www.ensemblgenomes.org/id/BAE77132 EnsemblBacteria BAE77132 http://www.ensemblgenomes.org/id/BAE77132 EnsemblBacteria BAE77132 http://www.ensemblgenomes.org/id/BAE77132 EnsemblBacteria b3082 http://www.ensemblgenomes.org/id/b3082 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.260.40 http://www.cathdb.info/version/latest/superfamily/1.10.260.40 GeneID 947593 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947593 HOGENOM HOG000026115 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000026115&db=HOGENOM6 IntAct P67701 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P67701* InterPro IPR001387 http://www.ebi.ac.uk/interpro/entry/IPR001387 InterPro IPR010982 http://www.ebi.ac.uk/interpro/entry/IPR010982 KEGG_Gene ecj:JW3053 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3053 KEGG_Gene eco:b3082 http://www.genome.jp/dbget-bin/www_bget?eco:b3082 OMA LACAKIT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LACAKIT PROSITE PS50943 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50943 PSORT swissprot:HIGA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HIGA_ECOLI PSORT-B swissprot:HIGA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HIGA_ECOLI PSORT2 swissprot:HIGA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HIGA_ECOLI Pfam PF01381 http://pfam.xfam.org/family/PF01381 Phobius swissprot:HIGA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HIGA_ECOLI ProteinModelPortal P67701 http://www.proteinmodelportal.org/query/uniprot/P67701 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19943910 http://www.ncbi.nlm.nih.gov/pubmed/19943910 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417553 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417553 RefSeq WP_000560266 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000560266 SMART SM00530 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00530 STRING 511145.b3082 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3082&targetmode=cogs SUPFAM SSF47413 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47413 UniProtKB HIGA_ECOLI http://www.uniprot.org/uniprot/HIGA_ECOLI UniProtKB-AC P67701 http://www.uniprot.org/uniprot/P67701 charge swissprot:HIGA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HIGA_ECOLI eggNOG COG5499 http://eggnogapi.embl.de/nog_data/html/tree/COG5499 eggNOG ENOG4108Z3N http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Z3N epestfind swissprot:HIGA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HIGA_ECOLI garnier swissprot:HIGA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HIGA_ECOLI helixturnhelix swissprot:HIGA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HIGA_ECOLI hmoment swissprot:HIGA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HIGA_ECOLI iep swissprot:HIGA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HIGA_ECOLI inforesidue swissprot:HIGA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HIGA_ECOLI octanol swissprot:HIGA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HIGA_ECOLI pepcoil swissprot:HIGA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HIGA_ECOLI pepdigest swissprot:HIGA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HIGA_ECOLI pepinfo swissprot:HIGA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HIGA_ECOLI pepnet swissprot:HIGA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HIGA_ECOLI pepstats swissprot:HIGA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HIGA_ECOLI pepwheel swissprot:HIGA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HIGA_ECOLI pepwindow swissprot:HIGA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HIGA_ECOLI sigcleave swissprot:HIGA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HIGA_ECOLI ## Database ID URL or Descriptions # BioGrid 4263288 9 # EcoGene EG11302 ydfC # Organism YDFC_ECOLI Escherichia coli (strain K12) # PATRIC 32118446 VBIEscCol129921_1643 # PIR D30383 Q4ECD8 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDFC_ECOLI Uncharacterized protein YdfC # RefSeq NP_416091 NC_000913.3 # RefSeq WP_001171942 NZ_LN832404.1 BLAST swissprot:YDFC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDFC_ECOLI BioCyc ECOL316407:JW1565-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1565-MONOMER BioCyc EcoCyc:EG11302-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11302-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/16.14.6327 http://dx.doi.org/10.1093/nar/16.14.6327 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X07465 http://www.ebi.ac.uk/ena/data/view/X07465 EchoBASE EB1279 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1279 EcoGene EG11302 http://www.ecogene.org/geneInfo.php?eg_id=EG11302 EnsemblBacteria AAC74646 http://www.ensemblgenomes.org/id/AAC74646 EnsemblBacteria AAC74646 http://www.ensemblgenomes.org/id/AAC74646 EnsemblBacteria BAA15278 http://www.ensemblgenomes.org/id/BAA15278 EnsemblBacteria BAA15278 http://www.ensemblgenomes.org/id/BAA15278 EnsemblBacteria BAA15278 http://www.ensemblgenomes.org/id/BAA15278 EnsemblBacteria b1573 http://www.ensemblgenomes.org/id/b1573 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946107 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946107 HOGENOM HOG000050870 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000050870&db=HOGENOM6 KEGG_Gene ecj:JW1565 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1565 KEGG_Gene eco:b1573 http://www.genome.jp/dbget-bin/www_bget?eco:b1573 OMA CEMHKTE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CEMHKTE PSORT swissprot:YDFC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDFC_ECOLI PSORT-B swissprot:YDFC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDFC_ECOLI PSORT2 swissprot:YDFC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDFC_ECOLI Phobius swissprot:YDFC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDFC_ECOLI ProteinModelPortal P21418 http://www.proteinmodelportal.org/query/uniprot/P21418 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3041373 http://www.ncbi.nlm.nih.gov/pubmed/3041373 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416091 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416091 RefSeq WP_001171942 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001171942 STRING 511145.b1573 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1573&targetmode=cogs UniProtKB YDFC_ECOLI http://www.uniprot.org/uniprot/YDFC_ECOLI UniProtKB-AC P21418 http://www.uniprot.org/uniprot/P21418 charge swissprot:YDFC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDFC_ECOLI epestfind swissprot:YDFC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDFC_ECOLI garnier swissprot:YDFC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDFC_ECOLI helixturnhelix swissprot:YDFC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDFC_ECOLI hmoment swissprot:YDFC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDFC_ECOLI iep swissprot:YDFC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDFC_ECOLI inforesidue swissprot:YDFC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDFC_ECOLI octanol swissprot:YDFC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDFC_ECOLI pepcoil swissprot:YDFC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDFC_ECOLI pepdigest swissprot:YDFC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDFC_ECOLI pepinfo swissprot:YDFC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDFC_ECOLI pepnet swissprot:YDFC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDFC_ECOLI pepstats swissprot:YDFC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDFC_ECOLI pepwheel swissprot:YDFC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDFC_ECOLI pepwindow swissprot:YDFC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDFC_ECOLI sigcleave swissprot:YDFC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDFC_ECOLI ## Database ID URL or Descriptions # BioGrid 4259151 20 # EcoGene EG13948 yobD # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # HAMAP MF_01071 UPF0266 # InterPro IPR009328 DUF986 # Organism YOBD_ECOLI Escherichia coli (strain K12) # PATRIC 32118959 VBIEscCol129921_1897 # PIR D64943 D64943 # PIRSF PIRSF020687 UCP020687 # Pfam PF06173 DUF986 # ProDom PD091196 DUF986 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YOBD_ECOLI UPF0266 membrane protein YobD # RefSeq NP_416334 NC_000913.3 # RefSeq WP_000156255 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0266 family. {ECO 0000305}. # SUBCELLULAR LOCATION YOBD_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG COG4811 LUCA # eggNOG ENOG4108NK4 Bacteria BLAST swissprot:YOBD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YOBD_ECOLI BioCyc ECOL316407:JW1809-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1809-MONOMER BioCyc EcoCyc:G6998-MONOMER http://biocyc.org/getid?id=EcoCyc:G6998-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3706 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3706 EcoGene EG13948 http://www.ecogene.org/geneInfo.php?eg_id=EG13948 EnsemblBacteria AAC74890 http://www.ensemblgenomes.org/id/AAC74890 EnsemblBacteria AAC74890 http://www.ensemblgenomes.org/id/AAC74890 EnsemblBacteria BAE76536 http://www.ensemblgenomes.org/id/BAE76536 EnsemblBacteria BAE76536 http://www.ensemblgenomes.org/id/BAE76536 EnsemblBacteria BAE76536 http://www.ensemblgenomes.org/id/BAE76536 EnsemblBacteria b1820 http://www.ensemblgenomes.org/id/b1820 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 946343 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946343 HAMAP MF_01071 http://hamap.expasy.org/unirule/MF_01071 HOGENOM HOG000249635 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000249635&db=HOGENOM6 IntAct P67601 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P67601* InterPro IPR009328 http://www.ebi.ac.uk/interpro/entry/IPR009328 KEGG_Gene ecj:JW1809 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1809 KEGG_Gene eco:b1820 http://www.genome.jp/dbget-bin/www_bget?eco:b1820 OMA LYLFWIR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LYLFWIR PSORT swissprot:YOBD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YOBD_ECOLI PSORT-B swissprot:YOBD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YOBD_ECOLI PSORT2 swissprot:YOBD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YOBD_ECOLI Pfam PF06173 http://pfam.xfam.org/family/PF06173 Phobius swissprot:YOBD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YOBD_ECOLI ProteinModelPortal P67601 http://www.proteinmodelportal.org/query/uniprot/P67601 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416334 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416334 RefSeq WP_000156255 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000156255 SMR P67601 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P67601 STRING 511145.b1820 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1820&targetmode=cogs UniProtKB YOBD_ECOLI http://www.uniprot.org/uniprot/YOBD_ECOLI UniProtKB-AC P67601 http://www.uniprot.org/uniprot/P67601 charge swissprot:YOBD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YOBD_ECOLI eggNOG COG4811 http://eggnogapi.embl.de/nog_data/html/tree/COG4811 eggNOG ENOG4108NK4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108NK4 epestfind swissprot:YOBD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YOBD_ECOLI garnier swissprot:YOBD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YOBD_ECOLI helixturnhelix swissprot:YOBD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YOBD_ECOLI hmoment swissprot:YOBD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YOBD_ECOLI iep swissprot:YOBD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YOBD_ECOLI inforesidue swissprot:YOBD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YOBD_ECOLI octanol swissprot:YOBD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YOBD_ECOLI pepcoil swissprot:YOBD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YOBD_ECOLI pepdigest swissprot:YOBD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YOBD_ECOLI pepinfo swissprot:YOBD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YOBD_ECOLI pepnet swissprot:YOBD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YOBD_ECOLI pepstats swissprot:YOBD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YOBD_ECOLI pepwheel swissprot:YOBD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YOBD_ECOLI pepwindow swissprot:YOBD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YOBD_ECOLI sigcleave swissprot:YOBD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YOBD_ECOLI ## Database ID URL or Descriptions # AltName SUFS_ECOLI Selenocysteine beta-lyase # AltName SUFS_ECOLI Selenocysteine lyase # AltName SUFS_ECOLI Selenocysteine reductase # BRENDA 2.8.1 2026 # BRENDA 4.4.1.16 2026 # BioGrid 4260281 57 # CATALYTIC ACTIVITY SUFS_ECOLI L-cysteine + acceptor = L-alanine + S- sulfanyl-acceptor. # CATALYTIC ACTIVITY SUFS_ECOLI L-selenocysteine + reduced acceptor = selenide + L-alanine + acceptor. # COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI 597326; # ENZYME REGULATION SUFS_ECOLI Displays a strong preference for selenocysteine as a substrate in vitro and is only very sightly active using cysteine. The interactions with SufE and the SufBCD complex act synergistically to enhance, up to 50-fold, its cysteine desulfurase activity. {ECO 0000269|PubMed 12876288, ECO 0000269|PubMed 12941942, ECO 0000269|PubMed 14644425}. # EcoGene EG13962 sufS # FUNCTION SUFS_ECOLI Cysteine desulfurases mobilize the sulfur from L- cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L-selenocysteine. Selenocysteine lyase activity is however unsure in vivo. {ECO 0000269|PubMed 10829016, ECO 0000269|PubMed 11997471, ECO 0000269|PubMed 12089140, ECO 0000269|PubMed 12876288, ECO 0000269|PubMed 12941942}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0009000 selenocysteine lyase activity; IDA:EcoCyc. # GO_function GO:0030170 pyridoxal phosphate binding; IDA:EcoCyc. # GO_function GO:0031071 cysteine desulfurase activity; IDA:EcoCyc. # GO_process GO:0001887 selenium compound metabolic process; IGI:EcoCyc. # GO_process GO:0006534 cysteine metabolic process; IEA:InterPro. # GO_process GO:0006790 sulfur compound metabolic process; IDA:EcoCyc. # GO_process GO:0016226 iron-sulfur cluster assembly; IDA:EcoCyc. # GO_process GO:0031162 sulfur incorporation into metallo-sulfur cluster; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.640.10 -; 1. # Gene3D 3.90.1150.10 -; 1. # HAMAP MF_01831 SufS_aminotrans_5 # INDUCTION SUFS_ECOLI Suf operon is under both the Fe-dependent Fur repressor and the oxidative stress dependent OxyR activator. # INTERACTION SUFS_ECOLI P76194 sufE; NbExp=3; IntAct=EBI-1124981, EBI-1124973; # IntAct P77444 14 # InterPro IPR000192 Aminotrans_V_dom # InterPro IPR010970 Cys_dSase_SufS # InterPro IPR015421 PyrdxlP-dep_Trfase_major_sub1 # InterPro IPR015422 PyrdxlP-dep_Trfase_major_sub2 # InterPro IPR015424 PyrdxlP-dep_Trfase # InterPro IPR020578 Aminotrans_V_PyrdxlP_BS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00450 Selenocompound metabolism # KEGG_Pathway ko00730 Thiamine metabolism # Organism SUFS_ECOLI Escherichia coli (strain K12) # PATHWAY SUFS_ECOLI Cofactor biosynthesis; iron-sulfur cluster biosynthesis. # PATRIC 32118666 VBIEscCol129921_1751 # PDB 1C0N X-ray; 2.80 A; A=1-406 # PDB 1I29 X-ray; 2.80 A; A=1-406 # PDB 1JF9 X-ray; 2.00 A; A=1-406 # PDB 1KMJ X-ray; 2.00 A; A=1-406 # PDB 1KMK X-ray; 2.20 A; A=1-406 # PDB 5DB5 X-ray; 2.75 A; A/B=1-406 # PIR H64925 H64925 # PROSITE PS00595 AA_TRANSFER_CLASS_5 # Pfam PF00266 Aminotran_5 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SUFS_ECOLI Cysteine desulfurase # RefSeq NP_416195 NC_000913.3 # RefSeq WP_000577988 NZ_LN832404.1 # SIMILARITY Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION SUFS_ECOLI Cytoplasm {ECO 0000250}. # SUBUNIT SUFS_ECOLI Homodimer. Interacts with SufE and the SufBCD complex composed of SufB, SufC and SufD. The interaction with SufE is required to mediate the direct transfer of the sulfur atom from the S-sulfanylcysteine. {ECO 0000269|PubMed 11827487, ECO 0000269|PubMed 12876288, ECO 0000269|PubMed 12941942, ECO 0000269|PubMed 14644425}. # SUPFAM SSF53383 SSF53383 # TIGRFAMs TIGR01979 sufS # eggNOG COG0520 LUCA # eggNOG ENOG4105C9B Bacteria BLAST swissprot:SUFS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SUFS_ECOLI BioCyc ECOL316407:JW1670-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1670-MONOMER BioCyc EcoCyc:G6906-MONOMER http://biocyc.org/getid?id=EcoCyc:G6906-MONOMER BioCyc MetaCyc:G6906-MONOMER http://biocyc.org/getid?id=MetaCyc:G6906-MONOMER COG COG0520 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0520 DIP DIP-9324N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9324N DOI 10.1006/jmbi.2001.5308 http://dx.doi.org/10.1006/jmbi.2001.5308 DOI 10.1016/S0014-5793(03)01244-4 http://dx.doi.org/10.1016/S0014-5793(03)01244-4 DOI 10.1021/bi991732a http://dx.doi.org/10.1021/bi991732a DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.102176099 http://dx.doi.org/10.1073/pnas.102176099 DOI 10.1074/jbc.274.21.14768 http://dx.doi.org/10.1074/jbc.274.21.14768 DOI 10.1074/jbc.C200365200 http://dx.doi.org/10.1074/jbc.C200365200 DOI 10.1074/jbc.M000926200 http://dx.doi.org/10.1074/jbc.M000926200 DOI 10.1074/jbc.M305953200 http://dx.doi.org/10.1074/jbc.M305953200 DOI 10.1074/jbc.M308004200 http://dx.doi.org/10.1074/jbc.M308004200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/oxfordjournals.jbchem.a003151 http://dx.doi.org/10.1093/oxfordjournals.jbchem.a003151 DOI 10.1093/oxfordjournals.jbchem.a022641 http://dx.doi.org/10.1093/oxfordjournals.jbchem.a022641 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.8.1.7 http://www.genome.jp/dbget-bin/www_bget?EC:2.8.1.7 EC_number EC:4.4.1.16 http://www.genome.jp/dbget-bin/www_bget?EC:4.4.1.16 EMBL AB055108 http://www.ebi.ac.uk/ena/data/view/AB055108 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.8.1.7 http://enzyme.expasy.org/EC/2.8.1.7 ENZYME 4.4.1.16 http://enzyme.expasy.org/EC/4.4.1.16 EchoBASE EB3720 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3720 EcoGene EG13962 http://www.ecogene.org/geneInfo.php?eg_id=EG13962 EnsemblBacteria AAC74750 http://www.ensemblgenomes.org/id/AAC74750 EnsemblBacteria AAC74750 http://www.ensemblgenomes.org/id/AAC74750 EnsemblBacteria BAA15457 http://www.ensemblgenomes.org/id/BAA15457 EnsemblBacteria BAA15457 http://www.ensemblgenomes.org/id/BAA15457 EnsemblBacteria BAA15457 http://www.ensemblgenomes.org/id/BAA15457 EnsemblBacteria b1680 http://www.ensemblgenomes.org/id/b1680 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0009000 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009000 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_function GO:0031071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031071 GO_process GO:0001887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001887 GO_process GO:0006534 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006534 GO_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GO_process GO:0016226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016226 GO_process GO:0031162 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031162 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.640.10 http://www.cathdb.info/version/latest/superfamily/3.40.640.10 Gene3D 3.90.1150.10 http://www.cathdb.info/version/latest/superfamily/3.90.1150.10 GeneID 946185 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946185 HAMAP MF_01831 http://hamap.expasy.org/unirule/MF_01831 HOGENOM HOG000017511 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000017511&db=HOGENOM6 InParanoid P77444 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77444 IntAct P77444 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77444* IntEnz 2.8.1.7 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.8.1.7 IntEnz 4.4.1.16 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.4.1.16 InterPro IPR000192 http://www.ebi.ac.uk/interpro/entry/IPR000192 InterPro IPR010970 http://www.ebi.ac.uk/interpro/entry/IPR010970 InterPro IPR015421 http://www.ebi.ac.uk/interpro/entry/IPR015421 InterPro IPR015422 http://www.ebi.ac.uk/interpro/entry/IPR015422 InterPro IPR015424 http://www.ebi.ac.uk/interpro/entry/IPR015424 InterPro IPR020578 http://www.ebi.ac.uk/interpro/entry/IPR020578 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1670 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1670 KEGG_Gene eco:b1680 http://www.genome.jp/dbget-bin/www_bget?eco:b1680 KEGG_Orthology KO:K11717 http://www.genome.jp/dbget-bin/www_bget?KO:K11717 KEGG_Pathway ko00450 http://www.genome.jp/kegg-bin/show_pathway?ko00450 KEGG_Pathway ko00730 http://www.genome.jp/kegg-bin/show_pathway?ko00730 KEGG_Reaction rn:R03599 http://www.genome.jp/dbget-bin/www_bget?rn:R03599 KEGG_Reaction rn:R09366 http://www.genome.jp/dbget-bin/www_bget?rn:R09366 OMA AEKVHGK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AEKVHGK PDB 1C0N http://www.ebi.ac.uk/pdbe-srv/view/entry/1C0N PDB 1I29 http://www.ebi.ac.uk/pdbe-srv/view/entry/1I29 PDB 1JF9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1JF9 PDB 1KMJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1KMJ PDB 1KMK http://www.ebi.ac.uk/pdbe-srv/view/entry/1KMK PDB 5DB5 http://www.ebi.ac.uk/pdbe-srv/view/entry/5DB5 PDBsum 1C0N http://www.ebi.ac.uk/pdbsum/1C0N PDBsum 1I29 http://www.ebi.ac.uk/pdbsum/1I29 PDBsum 1JF9 http://www.ebi.ac.uk/pdbsum/1JF9 PDBsum 1KMJ http://www.ebi.ac.uk/pdbsum/1KMJ PDBsum 1KMK http://www.ebi.ac.uk/pdbsum/1KMK PDBsum 5DB5 http://www.ebi.ac.uk/pdbsum/5DB5 PROSITE PS00595 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00595 PSORT swissprot:SUFS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SUFS_ECOLI PSORT-B swissprot:SUFS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SUFS_ECOLI PSORT2 swissprot:SUFS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SUFS_ECOLI Pfam PF00266 http://pfam.xfam.org/family/PF00266 Phobius swissprot:SUFS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SUFS_ECOLI PhylomeDB P77444 http://phylomedb.org/?seqid=P77444 ProteinModelPortal P77444 http://www.proteinmodelportal.org/query/uniprot/P77444 PubMed 10322040 http://www.ncbi.nlm.nih.gov/pubmed/10322040 PubMed 10329673 http://www.ncbi.nlm.nih.gov/pubmed/10329673 PubMed 10684605 http://www.ncbi.nlm.nih.gov/pubmed/10684605 PubMed 10739946 http://www.ncbi.nlm.nih.gov/pubmed/10739946 PubMed 10829016 http://www.ncbi.nlm.nih.gov/pubmed/10829016 PubMed 11827487 http://www.ncbi.nlm.nih.gov/pubmed/11827487 PubMed 11983074 http://www.ncbi.nlm.nih.gov/pubmed/11983074 PubMed 11997471 http://www.ncbi.nlm.nih.gov/pubmed/11997471 PubMed 12089140 http://www.ncbi.nlm.nih.gov/pubmed/12089140 PubMed 12876288 http://www.ncbi.nlm.nih.gov/pubmed/12876288 PubMed 12941942 http://www.ncbi.nlm.nih.gov/pubmed/12941942 PubMed 14644425 http://www.ncbi.nlm.nih.gov/pubmed/14644425 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416195 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416195 RefSeq WP_000577988 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000577988 SMR P77444 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77444 STRING 511145.b1680 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1680&targetmode=cogs STRING COG0520 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0520&targetmode=cogs SUPFAM SSF53383 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53383 TIGRFAMs TIGR01979 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01979 UniProtKB SUFS_ECOLI http://www.uniprot.org/uniprot/SUFS_ECOLI UniProtKB-AC P77444 http://www.uniprot.org/uniprot/P77444 charge swissprot:SUFS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SUFS_ECOLI eggNOG COG0520 http://eggnogapi.embl.de/nog_data/html/tree/COG0520 eggNOG ENOG4105C9B http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C9B epestfind swissprot:SUFS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SUFS_ECOLI garnier swissprot:SUFS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SUFS_ECOLI helixturnhelix swissprot:SUFS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SUFS_ECOLI hmoment swissprot:SUFS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SUFS_ECOLI iep swissprot:SUFS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SUFS_ECOLI inforesidue swissprot:SUFS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SUFS_ECOLI octanol swissprot:SUFS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SUFS_ECOLI pepcoil swissprot:SUFS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SUFS_ECOLI pepdigest swissprot:SUFS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SUFS_ECOLI pepinfo swissprot:SUFS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SUFS_ECOLI pepnet swissprot:SUFS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SUFS_ECOLI pepstats swissprot:SUFS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SUFS_ECOLI pepwheel swissprot:SUFS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SUFS_ECOLI pepwindow swissprot:SUFS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SUFS_ECOLI sigcleave swissprot:SUFS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SUFS_ECOLI ## Database ID URL or Descriptions # EcoGene EG10764 priB # FUNCTION PRIB_ECOLI Binds single-stranded DNA at the primosome assembly site (PAS). During primosome assembly it facilitates the complex formation between PriA and DnaT. {ECO 0000255|HAMAP-Rule MF_00720, ECO 0000269|PubMed 1646811, ECO 0000269|PubMed 1856227, ECO 0000269|PubMed 8366072}. # GO_component GO:1990099 pre-primosome complex; IMP:UniProtKB. # GO_function GO:0003697 single-stranded DNA binding; IDA:EcoCyc. # GO_process GO:0006269 DNA replication, synthesis of RNA primer; IEA:UniProtKB-KW. # GO_process GO:0006270 DNA replication initiation; IMP:EcoCyc. # GO_process GO:0006276 plasmid maintenance; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # HAMAP MF_00720 PriB # INDUCTION Induced by hydroxyurea. {ECO:0000269|PubMed 20005847}. # INTERACTION PRIB_ECOLI P0A8J2 dnaT; NbExp=4; IntAct=EBI-1125223, EBI-549621; P17888 priA; NbExp=3; IntAct=EBI-1125223, EBI-552050; # IntAct P07013 12 # InterPro IPR000424 Primosome_PriB/ssb # InterPro IPR012340 NA-bd_OB-fold # InterPro IPR023646 Prisomal_replication_PriB # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko03440 Homologous recombination # Organism PRIB_ECOLI Escherichia coli (strain K12) # PATRIC 32123977 VBIEscCol129921_4333 # PDB 1TXY X-ray; 2.00 A; A/B=1-104 # PDB 1V1Q X-ray; 2.10 A; A/B=1-102 # PDB 1WOC X-ray; 2.00 A; A/B/C/D=2-104 # PDB 2CCZ X-ray; 2.70 A; A/B=1-102 # PDB 2PNH X-ray; 2.25 A; A/B=1-104 # PIR A30281 Q4ECFR # PIRSF PIRSF003135 Primosomal_n # PROSITE PS50935 SSB # Pfam PF00436 SSB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Primosomal replication protein N {ECO:0000255|HAMAP-Rule MF_00720} # RefSeq NP_418622 NC_000913.3 # RefSeq WP_001315977 NZ_LN832404.1 # SIMILARITY Belongs to the PriB family. {ECO:0000255|HAMAP- Rule MF_00720, ECO:0000305}. # SIMILARITY Contains 1 SSB domain. {ECO:0000255|HAMAP- Rule MF_00720}. # SUBUNIT PRIB_ECOLI Component of the preprimosomal complex composed of one monomer of PriC and DnaT, two monomers of PriA, two dimers of PriB and one hexamer of DnaB. Upon transient interaction with DnaG it forms the primosome. {ECO 0000255|HAMAP-Rule MF_00720, ECO 0000269|PubMed 8663106}. # SUPFAM SSF50249 SSF50249 # TIGRFAMs TIGR04418 PriB_gamma # eggNOG COG2965 LUCA # eggNOG ENOG4108VDV Bacteria BLAST swissprot:PRIB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PRIB_ECOLI BioCyc ECOL316407:JW4159-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4159-MONOMER BioCyc EcoCyc:EG10764-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10764-MONOMER BioCyc MetaCyc:EG10764-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10764-MONOMER COG COG2965 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2965 DIP DIP-10563N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10563N DOI 10.1007/BF00330199 http://dx.doi.org/10.1007/BF00330199 DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.271.26.15656 http://dx.doi.org/10.1074/jbc.271.26.15656 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X04022 http://www.ebi.ac.uk/ena/data/view/X04022 EchoBASE EB0757 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0757 EcoGene EG10764 http://www.ecogene.org/geneInfo.php?eg_id=EG10764 EnsemblBacteria AAC77158 http://www.ensemblgenomes.org/id/AAC77158 EnsemblBacteria AAC77158 http://www.ensemblgenomes.org/id/AAC77158 EnsemblBacteria BAE78202 http://www.ensemblgenomes.org/id/BAE78202 EnsemblBacteria BAE78202 http://www.ensemblgenomes.org/id/BAE78202 EnsemblBacteria BAE78202 http://www.ensemblgenomes.org/id/BAE78202 EnsemblBacteria b4201 http://www.ensemblgenomes.org/id/b4201 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:1990099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990099 GO_function GO:0003697 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003697 GO_process GO:0006269 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006269 GO_process GO:0006270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006270 GO_process GO:0006276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006276 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 948722 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948722 HAMAP MF_00720 http://hamap.expasy.org/unirule/MF_00720 HOGENOM HOG000261221 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261221&db=HOGENOM6 IntAct P07013 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P07013* InterPro IPR000424 http://www.ebi.ac.uk/interpro/entry/IPR000424 InterPro IPR012340 http://www.ebi.ac.uk/interpro/entry/IPR012340 InterPro IPR023646 http://www.ebi.ac.uk/interpro/entry/IPR023646 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW4159 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4159 KEGG_Gene eco:b4201 http://www.genome.jp/dbget-bin/www_bget?eco:b4201 KEGG_Orthology KO:K02686 http://www.genome.jp/dbget-bin/www_bget?KO:K02686 KEGG_Pathway ko03440 http://www.genome.jp/kegg-bin/show_pathway?ko03440 OMA CQMPVII http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CQMPVII PDB 1TXY http://www.ebi.ac.uk/pdbe-srv/view/entry/1TXY PDB 1V1Q http://www.ebi.ac.uk/pdbe-srv/view/entry/1V1Q PDB 1WOC http://www.ebi.ac.uk/pdbe-srv/view/entry/1WOC PDB 2CCZ http://www.ebi.ac.uk/pdbe-srv/view/entry/2CCZ PDB 2PNH http://www.ebi.ac.uk/pdbe-srv/view/entry/2PNH PDBsum 1TXY http://www.ebi.ac.uk/pdbsum/1TXY PDBsum 1V1Q http://www.ebi.ac.uk/pdbsum/1V1Q PDBsum 1WOC http://www.ebi.ac.uk/pdbsum/1WOC PDBsum 2CCZ http://www.ebi.ac.uk/pdbsum/2CCZ PDBsum 2PNH http://www.ebi.ac.uk/pdbsum/2PNH PROSITE PS50935 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50935 PSORT swissprot:PRIB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PRIB_ECOLI PSORT-B swissprot:PRIB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PRIB_ECOLI PSORT2 swissprot:PRIB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PRIB_ECOLI Pfam PF00436 http://pfam.xfam.org/family/PF00436 Phobius swissprot:PRIB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PRIB_ECOLI ProteinModelPortal P07013 http://www.proteinmodelportal.org/query/uniprot/P07013 PubMed 1646811 http://www.ncbi.nlm.nih.gov/pubmed/1646811 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1856227 http://www.ncbi.nlm.nih.gov/pubmed/1856227 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 3528756 http://www.ncbi.nlm.nih.gov/pubmed/3528756 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8366072 http://www.ncbi.nlm.nih.gov/pubmed/8366072 PubMed 8663106 http://www.ncbi.nlm.nih.gov/pubmed/8663106 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418622 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418622 RefSeq WP_001315977 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001315977 SMR P07013 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P07013 STRING 511145.b4201 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4201&targetmode=cogs STRING COG2965 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2965&targetmode=cogs SUPFAM SSF50249 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50249 TIGRFAMs TIGR04418 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR04418 UniProtKB PRIB_ECOLI http://www.uniprot.org/uniprot/PRIB_ECOLI UniProtKB-AC P07013 http://www.uniprot.org/uniprot/P07013 charge swissprot:PRIB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PRIB_ECOLI eggNOG COG2965 http://eggnogapi.embl.de/nog_data/html/tree/COG2965 eggNOG ENOG4108VDV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108VDV epestfind swissprot:PRIB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PRIB_ECOLI garnier swissprot:PRIB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PRIB_ECOLI helixturnhelix swissprot:PRIB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PRIB_ECOLI hmoment swissprot:PRIB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PRIB_ECOLI iep swissprot:PRIB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PRIB_ECOLI inforesidue swissprot:PRIB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PRIB_ECOLI octanol swissprot:PRIB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PRIB_ECOLI pepcoil swissprot:PRIB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PRIB_ECOLI pepdigest swissprot:PRIB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PRIB_ECOLI pepinfo swissprot:PRIB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PRIB_ECOLI pepnet swissprot:PRIB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PRIB_ECOLI pepstats swissprot:PRIB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PRIB_ECOLI pepwheel swissprot:PRIB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PRIB_ECOLI pepwindow swissprot:PRIB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PRIB_ECOLI sigcleave swissprot:PRIB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PRIB_ECOLI ## Database ID URL or Descriptions # BioGrid 4263228 428 # EcoGene EG10778 pspC # FUNCTION PSPC_ECOLI The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions. PspC is involved in transcription regulation. {ECO 0000269|PubMed 1712397}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # INDUCTION By heat, ethanol, osmotic shock and infection by filamentous bacteriophages. {ECO:0000269|PubMed 1712397}. # IntAct P0AFN2 3 # InterPro IPR007168 Phageshock_PspC_N # InterPro IPR014320 Phageshock_PspC # KEGG_Brite ko03000 Transcription factors # Organism PSPC_ECOLI Escherichia coli (strain K12) # PATRIC 32117884 VBIEscCol129921_1362 # PIR S17123 S17123 # Pfam PF04024 PspC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PSPC_ECOLI Phage shock protein C # RefSeq NP_415822 NC_000913.3 # RefSeq WP_000907387 NZ_LN832404.1 # SIMILARITY Belongs to the phageshock PspC family. {ECO 0000305}. # SUBCELLULAR LOCATION PSPC_ECOLI Cell inner membrane {ECO 0000305}; Single- pass membrane protein {ECO 0000305}. # SUBUNIT Interacts with PspA. {ECO:0000269|PubMed 12562786}. # TIGRFAMs TIGR02978 phageshock_pspC # eggNOG COG1983 LUCA # eggNOG ENOG4105FM1 Bacteria BLAST swissprot:PSPC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PSPC_ECOLI BioCyc ECOL316407:JW1299-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1299-MONOMER BioCyc EcoCyc:EG10778-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10778-MONOMER COG COG1983 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1983 DIP DIP-48215N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48215N DOI 10.1016/0022-2836(91)90379-K http://dx.doi.org/10.1016/0022-2836(91)90379-K DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.185.4.1174-1180.2003 http://dx.doi.org/10.1128/JB.185.4.1174-1180.2003 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X57560 http://www.ebi.ac.uk/ena/data/view/X57560 EchoBASE EB0771 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0771 EcoGene EG10778 http://www.ecogene.org/geneInfo.php?eg_id=EG10778 EnsemblBacteria AAC74388 http://www.ensemblgenomes.org/id/AAC74388 EnsemblBacteria AAC74388 http://www.ensemblgenomes.org/id/AAC74388 EnsemblBacteria BAA14875 http://www.ensemblgenomes.org/id/BAA14875 EnsemblBacteria BAA14875 http://www.ensemblgenomes.org/id/BAA14875 EnsemblBacteria BAA14875 http://www.ensemblgenomes.org/id/BAA14875 EnsemblBacteria b1306 http://www.ensemblgenomes.org/id/b1306 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 945499 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945499 HOGENOM HOG000276525 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276525&db=HOGENOM6 IntAct P0AFN2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFN2* InterPro IPR007168 http://www.ebi.ac.uk/interpro/entry/IPR007168 InterPro IPR014320 http://www.ebi.ac.uk/interpro/entry/IPR014320 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW1299 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1299 KEGG_Gene eco:b1306 http://www.genome.jp/dbget-bin/www_bget?eco:b1306 KEGG_Orthology KO:K03973 http://www.genome.jp/dbget-bin/www_bget?KO:K03973 OMA MEAYVTS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MEAYVTS PSORT swissprot:PSPC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PSPC_ECOLI PSORT-B swissprot:PSPC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PSPC_ECOLI PSORT2 swissprot:PSPC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PSPC_ECOLI Pfam PF04024 http://pfam.xfam.org/family/PF04024 Phobius swissprot:PSPC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PSPC_ECOLI ProteinModelPortal P0AFN2 http://www.proteinmodelportal.org/query/uniprot/P0AFN2 PubMed 12562786 http://www.ncbi.nlm.nih.gov/pubmed/12562786 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1712397 http://www.ncbi.nlm.nih.gov/pubmed/1712397 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415822 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415822 RefSeq WP_000907387 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000907387 SMR P0AFN2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFN2 STRING 511145.b1306 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1306&targetmode=cogs STRING COG1983 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1983&targetmode=cogs TIGRFAMs TIGR02978 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02978 UniProtKB PSPC_ECOLI http://www.uniprot.org/uniprot/PSPC_ECOLI UniProtKB-AC P0AFN2 http://www.uniprot.org/uniprot/P0AFN2 charge swissprot:PSPC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PSPC_ECOLI eggNOG COG1983 http://eggnogapi.embl.de/nog_data/html/tree/COG1983 eggNOG ENOG4105FM1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FM1 epestfind swissprot:PSPC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PSPC_ECOLI garnier swissprot:PSPC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PSPC_ECOLI helixturnhelix swissprot:PSPC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PSPC_ECOLI hmoment swissprot:PSPC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PSPC_ECOLI iep swissprot:PSPC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PSPC_ECOLI inforesidue swissprot:PSPC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PSPC_ECOLI octanol swissprot:PSPC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PSPC_ECOLI pepcoil swissprot:PSPC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PSPC_ECOLI pepdigest swissprot:PSPC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PSPC_ECOLI pepinfo swissprot:PSPC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PSPC_ECOLI pepnet swissprot:PSPC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PSPC_ECOLI pepstats swissprot:PSPC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PSPC_ECOLI pepwheel swissprot:PSPC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PSPC_ECOLI pepwindow swissprot:PSPC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PSPC_ECOLI sigcleave swissprot:PSPC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PSPC_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES TYSY_ECOLI Kinetic parameters KM=50 uM for dUMP {ECO 0000269|PubMed 3286637}; KM=25 uM for 5,10-methylenetetrahydrofolate {ECO 0000269|PubMed 3286637}; KM=4.1 uM for dUMP {ECO 0000269|PubMed 9826509}; KM=13.6 uM for 5,10-methylenetetrahydrofolate {ECO 0000269|PubMed 9826509}; Vmax=5.47 umol/min/mg enzyme {ECO 0000269|PubMed 3286637}; Note=kcat is 8.8 sec(-1). {ECO 0000269|PubMed 9826509}; # BRENDA 2.1.1.45 2026 # BioGrid 4262058 195 # CATALYTIC ACTIVITY TYSY_ECOLI 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. {ECO 0000255|HAMAP-Rule MF_00008, ECO 0000269|PubMed 2223754, ECO 0000269|PubMed 3286637, ECO 0000269|PubMed 9826509}. # CDD cd00351 TS_Pyrimidine_HMase # EcoGene EG11002 thyA # FUNCTION TYSY_ECOLI Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product (PubMed 3286637, PubMed 2223754, PubMed 9826509). This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. This protein also binds to its mRNA thus repressing its own translation (PubMed 7708505). {ECO 0000269|PubMed 2223754, ECO 0000269|PubMed 3286637, ECO 0000269|PubMed 7708505, ECO 0000269|PubMed 9826509}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003723 RNA binding; IEA:UniProtKB-KW. # GO_function GO:0004799 thymidylate synthase activity; IDA:EcoCyc. # GO_process GO:0006231 dTMP biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0006235 dTTP biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0006417 regulation of translation; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.30.572.10 -; 1. # HAMAP MF_00008 Thymidy_synth_bact # IntAct P0A884 5 # InterPro IPR000398 Thymidylate_synthase # InterPro IPR020940 Thymidylate_synthase_AS # InterPro IPR023451 Thymidate_synth/dCMP_Mease # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00240 Pyrimidine metabolism # KEGG_Pathway ko00670 One carbon pool by folate # Organism TYSY_ECOLI Escherichia coli (strain K12) # PATHWAY Pyrimidine metabolism; dTTP biosynthesis. {ECO:0000255|HAMAP-Rule MF_00008}. # PATRIC 32121072 VBIEscCol129921_2925 # PDB 1AIQ X-ray; 2.20 A; A/B=1-264 # PDB 1AJM X-ray; 2.40 A; A=1-264 # PDB 1AN5 X-ray; 2.60 A; A/B=1-264 # PDB 1AOB X-ray; 2.10 A; A=1-264 # PDB 1AXW X-ray; 1.70 A; A/B=1-264 # PDB 1BDU X-ray; 2.10 A; A=1-264 # PDB 1BID X-ray; 2.20 A; A=1-264 # PDB 1BJG X-ray; 2.30 A; A=1-264 # PDB 1BQ1 X-ray; 2.50 A; A/B=1-264 # PDB 1BQ2 X-ray; 2.20 A; A=1-264 # PDB 1DDU X-ray; 2.10 A; A/B=1-264 # PDB 1DNA X-ray; 2.20 A; A/B=1-264 # PDB 1EV5 X-ray; 1.70 A; A=1-264 # PDB 1EV8 X-ray; 2.60 A; A=1-264 # PDB 1EVF X-ray; 1.70 A; A=1-264 # PDB 1EVG X-ray; 2.00 A; A=1-264 # PDB 1F4B X-ray; 1.75 A; A=1-264 # PDB 1F4C X-ray; 2.00 A; A/B=1-264 # PDB 1F4D X-ray; 2.15 A; A/B=1-264 # PDB 1F4E X-ray; 1.90 A; A=1-264 # PDB 1F4F X-ray; 2.00 A; A/B=1-264 # PDB 1F4G X-ray; 1.75 A; A/B=1-264 # PDB 1FFL X-ray; 2.94 A; A=1-264 # PDB 1FWM X-ray; 2.20 A; A/B=1-264 # PDB 1JG0 X-ray; 2.00 A; A/B=1-264 # PDB 1JTQ X-ray; 2.50 A; A/B=1-264 # PDB 1JTU X-ray; 2.20 A; A/B=1-264 # PDB 1JUT X-ray; 2.70 A; A/B=1-264 # PDB 1KCE X-ray; 2.00 A; A/B=1-264 # PDB 1KZI X-ray; 1.75 A; A/B=1-264 # PDB 1KZJ X-ray; 2.60 A; A/B/C/D/E/F=1-264 # PDB 1NCE X-ray; 2.40 A; A/B=1-264 # PDB 1QQQ X-ray; 1.50 A; A=1-264 # PDB 1SYN X-ray; 2.00 A; A/B=1-264 # PDB 1TDU X-ray; 2.10 A; A/B=1-264 # PDB 1TJS X-ray; 2.20 A; A=1-264 # PDB 1TLC X-ray; 2.10 A; A/B=1-264 # PDB 1TLS X-ray; 2.60 A; A/B=1-264 # PDB 1TRG X-ray; 1.90 A; A=1-264 # PDB 1TSD X-ray; 1.95 A; A/B=1-264 # PDB 1TSN X-ray; 2.20 A; A=1-264 # PDB 1TYS X-ray; 1.80 A; A=1-264 # PDB 1ZPR X-ray; 2.50 A; A/B=1-264 # PDB 2A9W X-ray; 1.65 A; A/B/C/D=1-264 # PDB 2BBQ X-ray; 2.30 A; A/B=1-264 # PDB 2FTN X-ray; 1.60 A; A=1-264 # PDB 2FTO X-ray; 2.00 A; X=1-264 # PDB 2FTQ X-ray; 1.81 A; A=1-264 # PDB 2G8X X-ray; 1.83 A; A/B=1-264 # PDB 2KCE X-ray; 2.20 A; A/B=1-264 # PDB 2TSC X-ray; 1.97 A; A/B=1-264 # PDB 2VET X-ray; 2.20 A; A=1-264 # PDB 2VF0 X-ray; 3.00 A; A/B=1-264 # PDB 3B5B X-ray; 2.70 A; A/B=1-264 # PDB 3B9H X-ray; 2.49 A; A=1-264 # PDB 3BFI X-ray; 2.20 A; A=1-264 # PDB 3BGX X-ray; 1.93 A; A=1-264 # PDB 3BHL X-ray; 1.40 A; A/B=1-264 # PDB 3BHR X-ray; 1.90 A; A=1-264 # PDB 3TMS X-ray; 2.10 A; A=1-264 # PDB 4F2V X-ray; 2.49 A; A/B=1-264 # PDB 4GEV X-ray; 1.30 A; A/B=1-264 # PDB 4ISK X-ray; 1.75 A; A/B/C/D/E/F/G/H=2-264 # PDB 4KNZ X-ray; 1.30 A; A/B=1-264 # PIR A00549 SYECT # PRINTS PR00108 THYMDSNTHASE # PROSITE PS00091 THYMIDYLATE_SYNTHASE # PTM TYSY_ECOLI Although not discussed in the published references, Met-1 is represented in the submitted PDB entries as being modified by either a formyl, or a carboxyl group. The N-terminal is probably N-(dihydroxymethyl)methionine, the hydrated form of N- formylmethionine. # Pfam PF00303 Thymidylat_synt # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TYSY_ECOLI Thymidylate synthase {ECO 0000255|HAMAP-Rule MF_00008, ECO 0000303|PubMed 2223754, ECO 0000303|PubMed 3286637, ECO 0000303|PubMed 6308660} # RefSeq NP_417304 NC_000913.3 # RefSeq WP_000816232 NZ_LN832404.1 # SIMILARITY Belongs to the thymidylate synthase family. Bacterial- type ThyA subfamily. {ECO:0000255|HAMAP-Rule MF_00008}. # SUBCELLULAR LOCATION TYSY_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00008}. # SUBUNIT TYSY_ECOLI Homodimer. {ECO 0000269|PubMed 2223754, ECO 0000269|PubMed 8973201}. # SUPFAM SSF55831 SSF55831 # TIGRFAMs TIGR03284 thym_sym; 2 # eggNOG COG0207 LUCA # eggNOG ENOG4105C0V Bacteria BLAST swissprot:TYSY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TYSY_ECOLI BioCyc ECOL316407:JW2795-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2795-MONOMER BioCyc EcoCyc:THYMIDYLATESYN-MONOMER http://biocyc.org/getid?id=EcoCyc:THYMIDYLATESYN-MONOMER BioCyc MetaCyc:THYMIDYLATESYN-MONOMER http://biocyc.org/getid?id=MetaCyc:THYMIDYLATESYN-MONOMER COG COG0207 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0207 DIP DIP-48261N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48261N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/pro.5560061203 http://dx.doi.org/10.1002/pro.5560061203 DOI 10.1002/prot.340080406 http://dx.doi.org/10.1002/prot.340080406 DOI 10.1002/prot.340130407 http://dx.doi.org/10.1002/prot.340130407 DOI 10.1006/jmbi.1998.2205 http://dx.doi.org/10.1006/jmbi.1998.2205 DOI 10.1021/bi00172a029 http://dx.doi.org/10.1021/bi00172a029 DOI 10.1021/bi00482a004 http://dx.doi.org/10.1021/bi00482a004 DOI 10.1021/bi961269r http://dx.doi.org/10.1021/bi961269r DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.80.16.4914 http://dx.doi.org/10.1073/pnas.80.16.4914 DOI 10.1073/pnas.97.17.9367 http://dx.doi.org/10.1073/pnas.97.17.9367 DOI 10.1093/nar/14.11.4437 http://dx.doi.org/10.1093/nar/14.11.4437 DOI 10.1093/nar/23.5.869 http://dx.doi.org/10.1093/nar/23.5.869 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.1.45 {ECO:0000255|HAMAP-Rule:MF_00008, ECO:0000269|PubMed:2223754, ECO:0000269|PubMed:3286637, ECO:0000269|PubMed:9826509} http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.45 {ECO:0000255|HAMAP-Rule:MF_00008, ECO:0000269|PubMed:2223754, ECO:0000269|PubMed:3286637, ECO:0000269|PubMed:9826509} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01710 http://www.ebi.ac.uk/ena/data/view/J01710 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 EMBL X03966 http://www.ebi.ac.uk/ena/data/view/X03966 ENZYME 2.1.1.45 {ECO:0000255|HAMAP-Rule:MF_00008, ECO:0000269|PubMed:2223754, ECO:0000269|PubMed:3286637, ECO:0000269|PubMed:9826509} http://enzyme.expasy.org/EC/2.1.1.45 {ECO:0000255|HAMAP-Rule:MF_00008, ECO:0000269|PubMed:2223754, ECO:0000269|PubMed:3286637, ECO:0000269|PubMed:9826509} EchoBASE EB0995 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0995 EcoGene EG11002 http://www.ecogene.org/geneInfo.php?eg_id=EG11002 EnsemblBacteria AAC75866 http://www.ensemblgenomes.org/id/AAC75866 EnsemblBacteria AAC75866 http://www.ensemblgenomes.org/id/AAC75866 EnsemblBacteria BAE76896 http://www.ensemblgenomes.org/id/BAE76896 EnsemblBacteria BAE76896 http://www.ensemblgenomes.org/id/BAE76896 EnsemblBacteria BAE76896 http://www.ensemblgenomes.org/id/BAE76896 EnsemblBacteria b2827 http://www.ensemblgenomes.org/id/b2827 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0004799 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004799 GO_process GO:0006231 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006231 GO_process GO:0006235 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006235 GO_process GO:0006417 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006417 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.30.572.10 http://www.cathdb.info/version/latest/superfamily/3.30.572.10 GeneID 949035 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949035 HAMAP MF_00008 http://hamap.expasy.org/unirule/MF_00008 HOGENOM HOG000257900 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000257900&db=HOGENOM6 InParanoid P0A884 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A884 IntAct P0A884 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A884* IntEnz 2.1.1.45 {ECO:0000255|HAMAP-Rule:MF_00008, ECO:0000269|PubMed:2223754, ECO:0000269|PubMed:3286637, ECO:0000269|PubMed:9826509} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.45 {ECO:0000255|HAMAP-Rule:MF_00008, ECO:0000269|PubMed:2223754, ECO:0000269|PubMed:3286637, ECO:0000269|PubMed:9826509} InterPro IPR000398 http://www.ebi.ac.uk/interpro/entry/IPR000398 InterPro IPR020940 http://www.ebi.ac.uk/interpro/entry/IPR020940 InterPro IPR023451 http://www.ebi.ac.uk/interpro/entry/IPR023451 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2795 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2795 KEGG_Gene eco:b2827 http://www.genome.jp/dbget-bin/www_bget?eco:b2827 KEGG_Orthology KO:K00560 http://www.genome.jp/dbget-bin/www_bget?KO:K00560 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Pathway ko00670 http://www.genome.jp/kegg-bin/show_pathway?ko00670 KEGG_Reaction rn:R02101 http://www.genome.jp/dbget-bin/www_bget?rn:R02101 MINT MINT-1265510 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1265510 OMA IVYELLW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IVYELLW PDB 1AIQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1AIQ PDB 1AJM http://www.ebi.ac.uk/pdbe-srv/view/entry/1AJM PDB 1AN5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1AN5 PDB 1AOB http://www.ebi.ac.uk/pdbe-srv/view/entry/1AOB PDB 1AXW http://www.ebi.ac.uk/pdbe-srv/view/entry/1AXW PDB 1BDU http://www.ebi.ac.uk/pdbe-srv/view/entry/1BDU PDB 1BID http://www.ebi.ac.uk/pdbe-srv/view/entry/1BID PDB 1BJG http://www.ebi.ac.uk/pdbe-srv/view/entry/1BJG PDB 1BQ1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1BQ1 PDB 1BQ2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1BQ2 PDB 1DDU http://www.ebi.ac.uk/pdbe-srv/view/entry/1DDU PDB 1DNA http://www.ebi.ac.uk/pdbe-srv/view/entry/1DNA PDB 1EV5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1EV5 PDB 1EV8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1EV8 PDB 1EVF http://www.ebi.ac.uk/pdbe-srv/view/entry/1EVF PDB 1EVG http://www.ebi.ac.uk/pdbe-srv/view/entry/1EVG PDB 1F4B http://www.ebi.ac.uk/pdbe-srv/view/entry/1F4B PDB 1F4C http://www.ebi.ac.uk/pdbe-srv/view/entry/1F4C PDB 1F4D http://www.ebi.ac.uk/pdbe-srv/view/entry/1F4D PDB 1F4E http://www.ebi.ac.uk/pdbe-srv/view/entry/1F4E PDB 1F4F http://www.ebi.ac.uk/pdbe-srv/view/entry/1F4F PDB 1F4G http://www.ebi.ac.uk/pdbe-srv/view/entry/1F4G PDB 1FFL http://www.ebi.ac.uk/pdbe-srv/view/entry/1FFL PDB 1FWM http://www.ebi.ac.uk/pdbe-srv/view/entry/1FWM PDB 1JG0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1JG0 PDB 1JTQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1JTQ PDB 1JTU http://www.ebi.ac.uk/pdbe-srv/view/entry/1JTU PDB 1JUT http://www.ebi.ac.uk/pdbe-srv/view/entry/1JUT PDB 1KCE http://www.ebi.ac.uk/pdbe-srv/view/entry/1KCE PDB 1KZI http://www.ebi.ac.uk/pdbe-srv/view/entry/1KZI PDB 1KZJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1KZJ PDB 1NCE http://www.ebi.ac.uk/pdbe-srv/view/entry/1NCE PDB 1QQQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1QQQ PDB 1SYN http://www.ebi.ac.uk/pdbe-srv/view/entry/1SYN PDB 1TDU http://www.ebi.ac.uk/pdbe-srv/view/entry/1TDU PDB 1TJS http://www.ebi.ac.uk/pdbe-srv/view/entry/1TJS PDB 1TLC http://www.ebi.ac.uk/pdbe-srv/view/entry/1TLC PDB 1TLS http://www.ebi.ac.uk/pdbe-srv/view/entry/1TLS PDB 1TRG http://www.ebi.ac.uk/pdbe-srv/view/entry/1TRG PDB 1TSD http://www.ebi.ac.uk/pdbe-srv/view/entry/1TSD PDB 1TSN http://www.ebi.ac.uk/pdbe-srv/view/entry/1TSN PDB 1TYS http://www.ebi.ac.uk/pdbe-srv/view/entry/1TYS PDB 1ZPR http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZPR PDB 2A9W http://www.ebi.ac.uk/pdbe-srv/view/entry/2A9W PDB 2BBQ http://www.ebi.ac.uk/pdbe-srv/view/entry/2BBQ PDB 2FTN http://www.ebi.ac.uk/pdbe-srv/view/entry/2FTN PDB 2FTO http://www.ebi.ac.uk/pdbe-srv/view/entry/2FTO PDB 2FTQ http://www.ebi.ac.uk/pdbe-srv/view/entry/2FTQ PDB 2G8X http://www.ebi.ac.uk/pdbe-srv/view/entry/2G8X PDB 2KCE http://www.ebi.ac.uk/pdbe-srv/view/entry/2KCE PDB 2TSC http://www.ebi.ac.uk/pdbe-srv/view/entry/2TSC PDB 2VET http://www.ebi.ac.uk/pdbe-srv/view/entry/2VET PDB 2VF0 http://www.ebi.ac.uk/pdbe-srv/view/entry/2VF0 PDB 3B5B http://www.ebi.ac.uk/pdbe-srv/view/entry/3B5B PDB 3B9H http://www.ebi.ac.uk/pdbe-srv/view/entry/3B9H PDB 3BFI http://www.ebi.ac.uk/pdbe-srv/view/entry/3BFI PDB 3BGX http://www.ebi.ac.uk/pdbe-srv/view/entry/3BGX PDB 3BHL http://www.ebi.ac.uk/pdbe-srv/view/entry/3BHL PDB 3BHR http://www.ebi.ac.uk/pdbe-srv/view/entry/3BHR PDB 3TMS http://www.ebi.ac.uk/pdbe-srv/view/entry/3TMS PDB 4F2V http://www.ebi.ac.uk/pdbe-srv/view/entry/4F2V PDB 4GEV http://www.ebi.ac.uk/pdbe-srv/view/entry/4GEV PDB 4ISK http://www.ebi.ac.uk/pdbe-srv/view/entry/4ISK PDB 4KNZ http://www.ebi.ac.uk/pdbe-srv/view/entry/4KNZ PDBsum 1AIQ http://www.ebi.ac.uk/pdbsum/1AIQ PDBsum 1AJM http://www.ebi.ac.uk/pdbsum/1AJM PDBsum 1AN5 http://www.ebi.ac.uk/pdbsum/1AN5 PDBsum 1AOB http://www.ebi.ac.uk/pdbsum/1AOB PDBsum 1AXW http://www.ebi.ac.uk/pdbsum/1AXW PDBsum 1BDU http://www.ebi.ac.uk/pdbsum/1BDU PDBsum 1BID http://www.ebi.ac.uk/pdbsum/1BID PDBsum 1BJG http://www.ebi.ac.uk/pdbsum/1BJG PDBsum 1BQ1 http://www.ebi.ac.uk/pdbsum/1BQ1 PDBsum 1BQ2 http://www.ebi.ac.uk/pdbsum/1BQ2 PDBsum 1DDU http://www.ebi.ac.uk/pdbsum/1DDU PDBsum 1DNA http://www.ebi.ac.uk/pdbsum/1DNA PDBsum 1EV5 http://www.ebi.ac.uk/pdbsum/1EV5 PDBsum 1EV8 http://www.ebi.ac.uk/pdbsum/1EV8 PDBsum 1EVF http://www.ebi.ac.uk/pdbsum/1EVF PDBsum 1EVG http://www.ebi.ac.uk/pdbsum/1EVG PDBsum 1F4B http://www.ebi.ac.uk/pdbsum/1F4B PDBsum 1F4C http://www.ebi.ac.uk/pdbsum/1F4C PDBsum 1F4D http://www.ebi.ac.uk/pdbsum/1F4D PDBsum 1F4E http://www.ebi.ac.uk/pdbsum/1F4E PDBsum 1F4F http://www.ebi.ac.uk/pdbsum/1F4F PDBsum 1F4G http://www.ebi.ac.uk/pdbsum/1F4G PDBsum 1FFL http://www.ebi.ac.uk/pdbsum/1FFL PDBsum 1FWM http://www.ebi.ac.uk/pdbsum/1FWM PDBsum 1JG0 http://www.ebi.ac.uk/pdbsum/1JG0 PDBsum 1JTQ http://www.ebi.ac.uk/pdbsum/1JTQ PDBsum 1JTU http://www.ebi.ac.uk/pdbsum/1JTU PDBsum 1JUT http://www.ebi.ac.uk/pdbsum/1JUT PDBsum 1KCE http://www.ebi.ac.uk/pdbsum/1KCE PDBsum 1KZI http://www.ebi.ac.uk/pdbsum/1KZI PDBsum 1KZJ http://www.ebi.ac.uk/pdbsum/1KZJ PDBsum 1NCE http://www.ebi.ac.uk/pdbsum/1NCE PDBsum 1QQQ http://www.ebi.ac.uk/pdbsum/1QQQ PDBsum 1SYN http://www.ebi.ac.uk/pdbsum/1SYN PDBsum 1TDU http://www.ebi.ac.uk/pdbsum/1TDU PDBsum 1TJS http://www.ebi.ac.uk/pdbsum/1TJS PDBsum 1TLC http://www.ebi.ac.uk/pdbsum/1TLC PDBsum 1TLS http://www.ebi.ac.uk/pdbsum/1TLS PDBsum 1TRG http://www.ebi.ac.uk/pdbsum/1TRG PDBsum 1TSD http://www.ebi.ac.uk/pdbsum/1TSD PDBsum 1TSN http://www.ebi.ac.uk/pdbsum/1TSN PDBsum 1TYS http://www.ebi.ac.uk/pdbsum/1TYS PDBsum 1ZPR http://www.ebi.ac.uk/pdbsum/1ZPR PDBsum 2A9W http://www.ebi.ac.uk/pdbsum/2A9W PDBsum 2BBQ http://www.ebi.ac.uk/pdbsum/2BBQ PDBsum 2FTN http://www.ebi.ac.uk/pdbsum/2FTN PDBsum 2FTO http://www.ebi.ac.uk/pdbsum/2FTO PDBsum 2FTQ http://www.ebi.ac.uk/pdbsum/2FTQ PDBsum 2G8X http://www.ebi.ac.uk/pdbsum/2G8X PDBsum 2KCE http://www.ebi.ac.uk/pdbsum/2KCE PDBsum 2TSC http://www.ebi.ac.uk/pdbsum/2TSC PDBsum 2VET http://www.ebi.ac.uk/pdbsum/2VET PDBsum 2VF0 http://www.ebi.ac.uk/pdbsum/2VF0 PDBsum 3B5B http://www.ebi.ac.uk/pdbsum/3B5B PDBsum 3B9H http://www.ebi.ac.uk/pdbsum/3B9H PDBsum 3BFI http://www.ebi.ac.uk/pdbsum/3BFI PDBsum 3BGX http://www.ebi.ac.uk/pdbsum/3BGX PDBsum 3BHL http://www.ebi.ac.uk/pdbsum/3BHL PDBsum 3BHR http://www.ebi.ac.uk/pdbsum/3BHR PDBsum 3TMS http://www.ebi.ac.uk/pdbsum/3TMS PDBsum 4F2V http://www.ebi.ac.uk/pdbsum/4F2V PDBsum 4GEV http://www.ebi.ac.uk/pdbsum/4GEV PDBsum 4ISK http://www.ebi.ac.uk/pdbsum/4ISK PDBsum 4KNZ http://www.ebi.ac.uk/pdbsum/4KNZ PRINTS PR00108 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00108 PROSITE PS00091 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00091 PSORT swissprot:TYSY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TYSY_ECOLI PSORT-B swissprot:TYSY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TYSY_ECOLI PSORT2 swissprot:TYSY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TYSY_ECOLI Pfam PF00303 http://pfam.xfam.org/family/PF00303 Phobius swissprot:TYSY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TYSY_ECOLI PhylomeDB P0A884 http://phylomedb.org/?seqid=P0A884 ProteinModelPortal P0A884 http://www.proteinmodelportal.org/query/uniprot/P0A884 PubMed 10944209 http://www.ncbi.nlm.nih.gov/pubmed/10944209 PubMed 1518803 http://www.ncbi.nlm.nih.gov/pubmed/1518803 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2128651 http://www.ncbi.nlm.nih.gov/pubmed/2128651 PubMed 2223754 http://www.ncbi.nlm.nih.gov/pubmed/2223754 PubMed 3286637 http://www.ncbi.nlm.nih.gov/pubmed/3286637 PubMed 3520484 http://www.ncbi.nlm.nih.gov/pubmed/3520484 PubMed 6308660 http://www.ncbi.nlm.nih.gov/pubmed/6308660 PubMed 7708505 http://www.ncbi.nlm.nih.gov/pubmed/7708505 PubMed 8312270 http://www.ncbi.nlm.nih.gov/pubmed/8312270 PubMed 8973201 http://www.ncbi.nlm.nih.gov/pubmed/8973201 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9416600 http://www.ncbi.nlm.nih.gov/pubmed/9416600 PubMed 9826509 http://www.ncbi.nlm.nih.gov/pubmed/9826509 RefSeq NP_417304 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417304 RefSeq WP_000816232 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000816232 SMR P0A884 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A884 STRING 511145.b2827 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2827&targetmode=cogs STRING COG0207 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0207&targetmode=cogs SUPFAM SSF55831 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55831 TIGRFAMs TIGR03284 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03284 UniProtKB TYSY_ECOLI http://www.uniprot.org/uniprot/TYSY_ECOLI UniProtKB-AC P0A884 http://www.uniprot.org/uniprot/P0A884 charge swissprot:TYSY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TYSY_ECOLI eggNOG COG0207 http://eggnogapi.embl.de/nog_data/html/tree/COG0207 eggNOG ENOG4105C0V http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C0V epestfind swissprot:TYSY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TYSY_ECOLI garnier swissprot:TYSY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TYSY_ECOLI helixturnhelix swissprot:TYSY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TYSY_ECOLI hmoment swissprot:TYSY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TYSY_ECOLI iep swissprot:TYSY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TYSY_ECOLI inforesidue swissprot:TYSY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TYSY_ECOLI octanol swissprot:TYSY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TYSY_ECOLI pepcoil swissprot:TYSY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TYSY_ECOLI pepdigest swissprot:TYSY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TYSY_ECOLI pepinfo swissprot:TYSY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TYSY_ECOLI pepnet swissprot:TYSY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TYSY_ECOLI pepstats swissprot:TYSY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TYSY_ECOLI pepwheel swissprot:TYSY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TYSY_ECOLI pepwindow swissprot:TYSY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TYSY_ECOLI sigcleave swissprot:TYSY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TYSY_ECOLI ## Database ID URL or Descriptions # BioGrid 4259703 13 # EcoGene EG13058 yqeB # InterPro IPR003777 XdhC_CoxI # InterPro IPR017695 Se-dep_Mo_hydrolase_YqeB # InterPro IPR027051 XdhC_Rossmann_dom # Organism YQEB_ECOLI Escherichia coli (strain K12) # PATRIC 32121160 VBIEscCol129921_2968 # PIR C65071 C65071 # Pfam PF02625 XdhC_CoxI # Pfam PF13478 XdhC_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQEB_ECOLI Uncharacterized protein YqeB # RefSeq NP_417351 NC_000913.3 # RefSeq WP_001020381 NZ_LN832404.1 # TIGRFAMs TIGR03309 matur_yqeB # eggNOG COG1975 LUCA # eggNOG ENOG4107P0T Bacteria BLAST swissprot:YQEB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQEB_ECOLI BioCyc ECOL316407:JW2843-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2843-MONOMER BioCyc EcoCyc:G7494-MONOMER http://biocyc.org/getid?id=EcoCyc:G7494-MONOMER COG COG1975 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1975 DIP DIP-12851N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12851N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 EchoBASE EB2870 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2870 EcoGene EG13058 http://www.ecogene.org/geneInfo.php?eg_id=EG13058 EnsemblBacteria AAC75913 http://www.ensemblgenomes.org/id/AAC75913 EnsemblBacteria AAC75913 http://www.ensemblgenomes.org/id/AAC75913 EnsemblBacteria BAE76941 http://www.ensemblgenomes.org/id/BAE76941 EnsemblBacteria BAE76941 http://www.ensemblgenomes.org/id/BAE76941 EnsemblBacteria BAE76941 http://www.ensemblgenomes.org/id/BAE76941 EnsemblBacteria b2875 http://www.ensemblgenomes.org/id/b2875 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947357 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947357 HOGENOM HOG000277415 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000277415&db=HOGENOM6 IntAct Q46808 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46808* InterPro IPR003777 http://www.ebi.ac.uk/interpro/entry/IPR003777 InterPro IPR017695 http://www.ebi.ac.uk/interpro/entry/IPR017695 InterPro IPR027051 http://www.ebi.ac.uk/interpro/entry/IPR027051 KEGG_Gene ecj:JW2843 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2843 KEGG_Gene eco:b2875 http://www.genome.jp/dbget-bin/www_bget?eco:b2875 KEGG_Orthology KO:K07402 http://www.genome.jp/dbget-bin/www_bget?KO:K07402 OMA ATNHQDK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ATNHQDK PSORT swissprot:YQEB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQEB_ECOLI PSORT-B swissprot:YQEB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQEB_ECOLI PSORT2 swissprot:YQEB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQEB_ECOLI Pfam PF02625 http://pfam.xfam.org/family/PF02625 Pfam PF13478 http://pfam.xfam.org/family/PF13478 Phobius swissprot:YQEB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQEB_ECOLI ProteinModelPortal Q46808 http://www.proteinmodelportal.org/query/uniprot/Q46808 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417351 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417351 RefSeq WP_001020381 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001020381 SMR Q46808 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46808 STRING 511145.b2875 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2875&targetmode=cogs STRING COG1975 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1975&targetmode=cogs TIGRFAMs TIGR03309 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03309 UniProtKB YQEB_ECOLI http://www.uniprot.org/uniprot/YQEB_ECOLI UniProtKB-AC Q46808 http://www.uniprot.org/uniprot/Q46808 charge swissprot:YQEB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQEB_ECOLI eggNOG COG1975 http://eggnogapi.embl.de/nog_data/html/tree/COG1975 eggNOG ENOG4107P0T http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107P0T epestfind swissprot:YQEB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQEB_ECOLI garnier swissprot:YQEB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQEB_ECOLI helixturnhelix swissprot:YQEB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQEB_ECOLI hmoment swissprot:YQEB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQEB_ECOLI iep swissprot:YQEB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQEB_ECOLI inforesidue swissprot:YQEB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQEB_ECOLI octanol swissprot:YQEB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQEB_ECOLI pepcoil swissprot:YQEB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQEB_ECOLI pepdigest swissprot:YQEB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQEB_ECOLI pepinfo swissprot:YQEB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQEB_ECOLI pepnet swissprot:YQEB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQEB_ECOLI pepstats swissprot:YQEB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQEB_ECOLI pepwheel swissprot:YQEB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQEB_ECOLI pepwindow swissprot:YQEB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQEB_ECOLI sigcleave swissprot:YQEB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQEB_ECOLI ## Database ID URL or Descriptions # AltName PROP_ECOLI Proline porter II # BIOPHYSICOCHEMICAL PROPERTIES PROP_ECOLI Kinetic parameters KM=175 uM for proline {ECO 0000269|PubMed 10026245}; Vmax=83.6 nmol/min/mg enzyme with proline as substrate {ECO 0000269|PubMed 10026245}; # BioGrid 4263085 4 # CDD cd06174 MFS # EcoGene EG11612 proP # FUNCTION PROP_ECOLI Proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. {ECO 0000269|PubMed 10026245, ECO 0000269|PubMed 3082857, ECO 0000269|PubMed 8421314}. # GO_component GO:0005886 plasma membrane; IDA:EcoliWiki. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IDA:EcoliWiki. # GO_function PROP_ECOLI GO 0015653 glycine betaine proton symporter activity; IDA EcoCyc. # GO_process GO:0006865 amino acid transport; IDA:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # INDUCTION Induced by an increase in the osmolarity of the growth medium. {ECO:0000269|PubMed 3082857}. # InterPro IPR004736 Cit_H_symport # InterPro IPR005828 MFS_sugar_transport-like # InterPro IPR005829 Sugar_transporter_CS # InterPro IPR015041 Osmo_CC # InterPro IPR020846 MFS_dom # KEGG_Brite ko02000 Transporters # Organism PROP_ECOLI Escherichia coli (strain K12) # PATRIC 32123787 VBIEscCol129921_4242 # PDB 1R48 NMR; -; A/B=468-497 # PDB 1Y8S Model; -; A=1-500 # PIR S32331 S32331 # PROSITE PS00216 SUGAR_TRANSPORT_1 # PROSITE PS50850 MFS # Pfam PF00083 Sugar_tr # Pfam PF08946 Osmo_CC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PROP_ECOLI Proline/betaine transporter # RefSeq NP_418535 NC_000913.3 # RefSeq WP_001298520 NZ_LN832404.1 # SIMILARITY Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. {ECO 0000305}. # SUBCELLULAR LOCATION PROP_ECOLI Cell inner membrane {ECO 0000269|PubMed 10026245, ECO 0000269|PubMed 15919996}; Multi- pass membrane protein {ECO 0000255}. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.6 the major facilitator superfamily (mfs) # TIGRFAMs TIGR00883 2A0106 # eggNOG ENOG4105CSH Bacteria # eggNOG ENOG410XP7I LUCA BLAST swissprot:PROP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PROP_ECOLI BioCyc ECOL316407:JW4072-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4072-MONOMER BioCyc EcoCyc:PROP-MONOMER http://biocyc.org/getid?id=EcoCyc:PROP-MONOMER BioCyc MetaCyc:PROP-MONOMER http://biocyc.org/getid?id=MetaCyc:PROP-MONOMER COG COG0477 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0477 DOI 10.1006/jmbi.1993.1030 http://dx.doi.org/10.1006/jmbi.1993.1030 DOI 10.1016/j.jmb.2003.10.020 http://dx.doi.org/10.1016/j.jmb.2003.10.020 DOI 10.1021/bi981279n http://dx.doi.org/10.1021/bi981279n DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M83089 http://www.ebi.ac.uk/ena/data/view/M83089 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB1569 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1569 EcoGene EG11612 http://www.ecogene.org/geneInfo.php?eg_id=EG11612 EnsemblBacteria AAC77072 http://www.ensemblgenomes.org/id/AAC77072 EnsemblBacteria AAC77072 http://www.ensemblgenomes.org/id/AAC77072 EnsemblBacteria BAE78113 http://www.ensemblgenomes.org/id/BAE78113 EnsemblBacteria BAE78113 http://www.ensemblgenomes.org/id/BAE78113 EnsemblBacteria BAE78113 http://www.ensemblgenomes.org/id/BAE78113 EnsemblBacteria b4111 http://www.ensemblgenomes.org/id/b4111 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015653 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015653 GO_process GO:0006865 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948626 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948626 HOGENOM HOG000141611 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000141611&db=HOGENOM6 InParanoid P0C0L7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0C0L7 InterPro IPR004736 http://www.ebi.ac.uk/interpro/entry/IPR004736 InterPro IPR005828 http://www.ebi.ac.uk/interpro/entry/IPR005828 InterPro IPR005829 http://www.ebi.ac.uk/interpro/entry/IPR005829 InterPro IPR015041 http://www.ebi.ac.uk/interpro/entry/IPR015041 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW4072 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4072 KEGG_Gene eco:b4111 http://www.genome.jp/dbget-bin/www_bget?eco:b4111 KEGG_Orthology KO:K03762 http://www.genome.jp/dbget-bin/www_bget?KO:K03762 OMA DYMVLSY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DYMVLSY PDB 1R48 http://www.ebi.ac.uk/pdbe-srv/view/entry/1R48 PDB 1Y8S http://www.ebi.ac.uk/pdbe-srv/view/entry/1Y8S PDBsum 1R48 http://www.ebi.ac.uk/pdbsum/1R48 PDBsum 1Y8S http://www.ebi.ac.uk/pdbsum/1Y8S PROSITE PS00216 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00216 PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:PROP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PROP_ECOLI PSORT-B swissprot:PROP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PROP_ECOLI PSORT2 swissprot:PROP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PROP_ECOLI Pfam PF00083 http://pfam.xfam.org/family/PF00083 Pfam PF08946 http://pfam.xfam.org/family/PF08946 Phobius swissprot:PROP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PROP_ECOLI PhylomeDB P0C0L7 http://phylomedb.org/?seqid=P0C0L7 ProteinModelPortal P0C0L7 http://www.proteinmodelportal.org/query/uniprot/P0C0L7 PubMed 10026245 http://www.ncbi.nlm.nih.gov/pubmed/10026245 PubMed 14643666 http://www.ncbi.nlm.nih.gov/pubmed/14643666 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3082857 http://www.ncbi.nlm.nih.gov/pubmed/3082857 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8421314 http://www.ncbi.nlm.nih.gov/pubmed/8421314 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418535 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418535 RefSeq WP_001298520 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001298520 SMR P0C0L7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0C0L7 STRING 511145.b4111 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4111&targetmode=cogs STRING COG0477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0477&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.6 http://www.tcdb.org/search/result.php?tc=2.A.1.6 TIGRFAMs TIGR00883 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00883 UniProtKB PROP_ECOLI http://www.uniprot.org/uniprot/PROP_ECOLI UniProtKB-AC P0C0L7 http://www.uniprot.org/uniprot/P0C0L7 charge swissprot:PROP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PROP_ECOLI eggNOG ENOG4105CSH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CSH eggNOG ENOG410XP7I http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XP7I epestfind swissprot:PROP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PROP_ECOLI garnier swissprot:PROP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PROP_ECOLI helixturnhelix swissprot:PROP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PROP_ECOLI hmoment swissprot:PROP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PROP_ECOLI iep swissprot:PROP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PROP_ECOLI inforesidue swissprot:PROP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PROP_ECOLI octanol swissprot:PROP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PROP_ECOLI pepcoil swissprot:PROP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PROP_ECOLI pepdigest swissprot:PROP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PROP_ECOLI pepinfo swissprot:PROP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PROP_ECOLI pepnet swissprot:PROP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PROP_ECOLI pepstats swissprot:PROP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PROP_ECOLI pepwheel swissprot:PROP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PROP_ECOLI pepwindow swissprot:PROP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PROP_ECOLI sigcleave swissprot:PROP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PROP_ECOLI ## Database ID URL or Descriptions # BioGrid 4261194 167 # CDD cd01346 Maltoporin-like # EcoGene EG11364 bglH # FUNCTION BGLH_ECOLI Part of a cryptic operon that is poorly expressed in vivo. May be an ancestral sugar porin with a broad carbohydrate specificity; it binds aromatic beta-D-glucosides such as arbutin and salicin, but with low affinity compared to the binding of maltooligosaccharides to the LamB porin. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_component GO:0046930 pore complex; IEA:UniProtKB-KW. # GO_function GO:0015144 carbohydrate transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0015288 porin activity; IEA:UniProtKB-KW. # GO_process GO:0006811 ion transport; IEA:UniProtKB-KW. # GO_process GO:0034219 carbohydrate transmembrane transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043234 protein complex # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # Gene3D 2.40.170.10 -; 1. # InterPro IPR003192 Porin_LamB # InterPro IPR021570 LamB-type_porin_N_dom # KEGG_Brite ko02000 Transporters # Organism BGLH_ECOLI Escherichia coli (strain K12) # PATRIC 32122935 VBIEscCol129921_3843 # PIR A65175 A65175 # Pfam PF02264 LamB # Pfam PF11471 Sugarporin_N # ProDom PD008788 Porin_LamB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BGLH_ECOLI Cryptic outer membrane porin BglH # RefSeq NP_418176 NC_000913.3 # RefSeq WP_000489881 NZ_LN832404.1 # SIMILARITY Belongs to the porin LamB (TC 1.B.3) family. {ECO 0000305}. # SUBCELLULAR LOCATION BGLH_ECOLI Cell outer membrane {ECO 0000305|PubMed 10027967}; Multi-pass membrane protein {ECO 0000305|PubMed 10027967}. Note=Can be easily removed from the outer membrane by treatment with detergent. # SUBUNIT BGLH_ECOLI Homomonomer; no physical evidence of a homotrimer has been found (PubMed 9426150, PubMed 10027967), however conductance experiments (PubMed 10027967) suggest it may be a homotrimer. The monomer probably consists of 18 antiparallel beta-strands. {ECO 0000269|PubMed 10027967, ECO 0000269|PubMed 9426150}. # TCDB 1.B.3.1 the sugar porin (sp) family # eggNOG COG4580 LUCA # eggNOG ENOG4108P68 Bacteria BLAST swissprot:BGLH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BGLH_ECOLI BioCyc ECOL316407:JW3698-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3698-MONOMER BioCyc EcoCyc:EG11364-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11364-MONOMER COG COG4580 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4580 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1999.01191.x http://dx.doi.org/10.1046/j.1365-2958.1999.01191.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M16487 http://www.ebi.ac.uk/ena/data/view/M16487 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1339 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1339 EcoGene EG11364 http://www.ecogene.org/geneInfo.php?eg_id=EG11364 EnsemblBacteria AAC76743 http://www.ensemblgenomes.org/id/AAC76743 EnsemblBacteria AAC76743 http://www.ensemblgenomes.org/id/AAC76743 EnsemblBacteria BAE77568 http://www.ensemblgenomes.org/id/BAE77568 EnsemblBacteria BAE77568 http://www.ensemblgenomes.org/id/BAE77568 EnsemblBacteria BAE77568 http://www.ensemblgenomes.org/id/BAE77568 EnsemblBacteria b3720 http://www.ensemblgenomes.org/id/b3720 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0046930 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046930 GO_function GO:0015144 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015144 GO_function GO:0015288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015288 GO_process GO:0006811 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811 GO_process GO:0034219 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034219 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 2.40.170.10 http://www.cathdb.info/version/latest/superfamily/2.40.170.10 GeneID 948228 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948228 HOGENOM HOG000120763 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120763&db=HOGENOM6 InterPro IPR003192 http://www.ebi.ac.uk/interpro/entry/IPR003192 InterPro IPR021570 http://www.ebi.ac.uk/interpro/entry/IPR021570 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3698 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3698 KEGG_Gene eco:b3720 http://www.genome.jp/dbget-bin/www_bget?eco:b3720 KEGG_Orthology KO:K10124 http://www.genome.jp/dbget-bin/www_bget?KO:K10124 OMA NTHTIDL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NTHTIDL PSORT swissprot:BGLH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BGLH_ECOLI PSORT-B swissprot:BGLH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BGLH_ECOLI PSORT2 swissprot:BGLH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BGLH_ECOLI Pfam PF02264 http://pfam.xfam.org/family/PF02264 Pfam PF11471 http://pfam.xfam.org/family/PF11471 Phobius swissprot:BGLH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BGLH_ECOLI ProteinModelPortal P26218 http://www.proteinmodelportal.org/query/uniprot/P26218 PubMed 10027967 http://www.ncbi.nlm.nih.gov/pubmed/10027967 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3034860 http://www.ncbi.nlm.nih.gov/pubmed/3034860 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9426150 http://www.ncbi.nlm.nih.gov/pubmed/9426150 RefSeq NP_418176 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418176 RefSeq WP_000489881 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000489881 STRING 511145.b3720 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3720&targetmode=cogs STRING COG4580 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4580&targetmode=cogs TCDB 1.B.3.1 http://www.tcdb.org/search/result.php?tc=1.B.3.1 UniProtKB BGLH_ECOLI http://www.uniprot.org/uniprot/BGLH_ECOLI UniProtKB-AC P26218 http://www.uniprot.org/uniprot/P26218 charge swissprot:BGLH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BGLH_ECOLI eggNOG COG4580 http://eggnogapi.embl.de/nog_data/html/tree/COG4580 eggNOG ENOG4108P68 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108P68 epestfind swissprot:BGLH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BGLH_ECOLI garnier swissprot:BGLH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BGLH_ECOLI helixturnhelix swissprot:BGLH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BGLH_ECOLI hmoment swissprot:BGLH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BGLH_ECOLI iep swissprot:BGLH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BGLH_ECOLI inforesidue swissprot:BGLH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BGLH_ECOLI octanol swissprot:BGLH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BGLH_ECOLI pepcoil swissprot:BGLH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BGLH_ECOLI pepdigest swissprot:BGLH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BGLH_ECOLI pepinfo swissprot:BGLH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BGLH_ECOLI pepnet swissprot:BGLH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BGLH_ECOLI pepstats swissprot:BGLH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BGLH_ECOLI pepwheel swissprot:BGLH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BGLH_ECOLI pepwindow swissprot:BGLH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BGLH_ECOLI sigcleave swissprot:BGLH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BGLH_ECOLI ## Database ID URL or Descriptions # BioGrid 4262266 14 # CDD cd00118 LysM # EcoGene EG12675 ygaU # Gene3D 3.10.350.10 -; 1. # InterPro IPR007055 BON_dom # InterPro IPR014004 Transpt-assoc_nodulatn_dom_bac # InterPro IPR018392 LysM_dom # Organism YGAU_ECOLI Escherichia coli (strain K12) # PATRIC 32120720 VBIEscCol129921_2757 # PDB 5FIM NMR; -; A=1-149 # PIR B65046 B65046 # PROSITE PS50914 BON # PROSITE PS51782 LYSM # Pfam PF01476 LysM # Pfam PF04972 BON # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGAU_ECOLI Uncharacterized protein YgaU # RefSeq NP_417151 NC_000913.3 # RefSeq WP_000522415 NZ_LN832404.1 # SIMILARITY Contains 1 BON domain. {ECO:0000255|PROSITE- ProRule PRU00229}. # SIMILARITY Contains 1 LysM domain. {ECO:0000255|PROSITE- ProRule PRU01118}. # SMART SM00257 LysM # SMART SM00749 BON # SUPFAM SSF54106 SSF54106 # eggNOG COG1652 LUCA # eggNOG ENOG4109066 Bacteria BLAST swissprot:YGAU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGAU_ECOLI BioCyc ECOL316407:JW2640-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2640-MONOMER BioCyc EcoCyc:G7395-MONOMER http://biocyc.org/getid?id=EcoCyc:G7395-MONOMER DIP DIP-48134N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48134N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2540 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2540 EcoGene EG12675 http://www.ecogene.org/geneInfo.php?eg_id=EG12675 EnsemblBacteria AAC75712 http://www.ensemblgenomes.org/id/AAC75712 EnsemblBacteria AAC75712 http://www.ensemblgenomes.org/id/AAC75712 EnsemblBacteria BAA16528 http://www.ensemblgenomes.org/id/BAA16528 EnsemblBacteria BAA16528 http://www.ensemblgenomes.org/id/BAA16528 EnsemblBacteria BAA16528 http://www.ensemblgenomes.org/id/BAA16528 EnsemblBacteria b2665 http://www.ensemblgenomes.org/id/b2665 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.10.350.10 http://www.cathdb.info/version/latest/superfamily/3.10.350.10 GeneID 947144 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947144 HOGENOM HOG000261244 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261244&db=HOGENOM6 InParanoid P0ADE6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADE6 IntAct P0ADE6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADE6* InterPro IPR007055 http://www.ebi.ac.uk/interpro/entry/IPR007055 InterPro IPR014004 http://www.ebi.ac.uk/interpro/entry/IPR014004 InterPro IPR018392 http://www.ebi.ac.uk/interpro/entry/IPR018392 KEGG_Gene ecj:JW2640 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2640 KEGG_Gene eco:b2665 http://www.genome.jp/dbget-bin/www_bget?eco:b2665 MINT MINT-1222147 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1222147 OMA AQYHDVV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AQYHDVV PDB 5FIM http://www.ebi.ac.uk/pdbe-srv/view/entry/5FIM PDBsum 5FIM http://www.ebi.ac.uk/pdbsum/5FIM PROSITE PS50914 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50914 PROSITE PS51782 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51782 PSORT swissprot:YGAU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGAU_ECOLI PSORT-B swissprot:YGAU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGAU_ECOLI PSORT2 swissprot:YGAU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGAU_ECOLI Pfam PF01476 http://pfam.xfam.org/family/PF01476 Pfam PF04972 http://pfam.xfam.org/family/PF04972 Phobius swissprot:YGAU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGAU_ECOLI PhylomeDB P0ADE6 http://phylomedb.org/?seqid=P0ADE6 ProteinModelPortal P0ADE6 http://www.proteinmodelportal.org/query/uniprot/P0ADE6 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_417151 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417151 RefSeq WP_000522415 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000522415 SMART SM00257 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00257 SMART SM00749 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00749 SMR P0ADE6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADE6 STRING 511145.b2665 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2665&targetmode=cogs SUPFAM SSF54106 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54106 SWISS-2DPAGE P0ADE6 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0ADE6 UniProtKB YGAU_ECOLI http://www.uniprot.org/uniprot/YGAU_ECOLI UniProtKB-AC P0ADE6 http://www.uniprot.org/uniprot/P0ADE6 charge swissprot:YGAU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGAU_ECOLI eggNOG COG1652 http://eggnogapi.embl.de/nog_data/html/tree/COG1652 eggNOG ENOG4109066 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4109066 epestfind swissprot:YGAU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGAU_ECOLI garnier swissprot:YGAU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGAU_ECOLI helixturnhelix swissprot:YGAU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGAU_ECOLI hmoment swissprot:YGAU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGAU_ECOLI iep swissprot:YGAU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGAU_ECOLI inforesidue swissprot:YGAU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGAU_ECOLI octanol swissprot:YGAU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGAU_ECOLI pepcoil swissprot:YGAU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGAU_ECOLI pepdigest swissprot:YGAU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGAU_ECOLI pepinfo swissprot:YGAU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGAU_ECOLI pepnet swissprot:YGAU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGAU_ECOLI pepstats swissprot:YGAU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGAU_ECOLI pepwheel swissprot:YGAU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGAU_ECOLI pepwindow swissprot:YGAU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGAU_ECOLI sigcleave swissprot:YGAU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGAU_ECOLI ## Database ID URL or Descriptions # AltName LGUL_ECOLI Aldoketomutase # AltName LGUL_ECOLI Glyoxalase I # AltName LGUL_ECOLI Ketone-aldehyde mutase # AltName LGUL_ECOLI Methylglyoxalase # AltName LGUL_ECOLI S-D-lactoylglutathione methylglyoxal lyase # BRENDA 4.4.1 2026 # BioGrid 4259387 10 # CATALYTIC ACTIVITY (R)-S-lactoylglutathione = glutathione + methylglyoxal. {ECO:0000269|PubMed 10913283}. # COFACTOR LGUL_ECOLI Name=Ni(2+); Xref=ChEBI CHEBI 49786; Evidence={ECO 0000269|PubMed 10913283}; Note=Binds 1 nickel ion per subunit. In the homodimer, two nickel ions are bound between subunits. Is not active with zinc ions. {ECO 0000269|PubMed 10913283}; # EcoGene EG13421 gloA # FUNCTION LGUL_ECOLI Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. {ECO 0000269|PubMed 10913283}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004462 lactoylglutathione lyase activity; IDA:EcoCyc. # GO_function GO:0016151 nickel cation binding; IDA:EcoCyc. # GO_process GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.10.180.10 -; 1. # INTERACTION LGUL_ECOLI P0A6Y8 dnaK; NbExp=2; IntAct=EBI-551143, EBI-542092; # IntAct P0AC81 6 # InterPro IPR004360 Glyas_Fos-R_dOase_dom # InterPro IPR004361 Glyoxalase_1 # InterPro IPR018146 Glyoxalase_1_CS # InterPro IPR029068 Glyas_Bleomycin-R_OHBP_Dase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00620 Pyruvate metabolism # KEGG_Pathway ko04011 MAPK signaling pathway - yeast # MASS SPECTROMETRY Mass=14919; Method=Electrospray; Range=1-135; Evidence={ECO:0000269|PubMed 9628737}; # Organism LGUL_ECOLI Escherichia coli (strain K12) # PATHWAY Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal step 1/2. # PATRIC 32118604 VBIEscCol129921_1722 # PDB 1F9Z X-ray; 1.50 A; A/B=1-135 # PDB 1FA5 X-ray; 1.80 A; A/B=1-135 # PDB 1FA6 X-ray; 1.90 A; A/B=1-135 # PDB 1FA7 X-ray; 1.90 A; A/B=1-135 # PDB 1FA8 X-ray; 1.70 A; A/B=1-135 # PIR E64922 E64922 # PROSITE PS00934 GLYOXALASE_I_1 # PROSITE PS00935 GLYOXALASE_I_2 # Pfam PF00903 Glyoxalase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LGUL_ECOLI Lactoylglutathione lyase # RefSeq NP_416168 NC_000913.3 # RefSeq WP_001237796 NZ_LN832404.1 # SIMILARITY Belongs to the glyoxalase I family. {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 10913283}. # SUPFAM SSF54593 SSF54593 # TIGRFAMs TIGR00068 glyox_I # UniPathway UPA00619 UER00675 # eggNOG COG0346 LUCA # eggNOG ENOG4108UYE Bacteria BLAST swissprot:LGUL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LGUL_ECOLI BioCyc ECOL316407:JW1643-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1643-MONOMER BioCyc EcoCyc:GLYOXI-MONOMER http://biocyc.org/getid?id=EcoCyc:GLYOXI-MONOMER BioCyc MetaCyc:GLYOXI-MONOMER http://biocyc.org/getid?id=MetaCyc:GLYOXI-MONOMER COG COG0346 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0346 DIP DIP-47995N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47995N DOI 10.1016/S0378-1119(96)00691-9 http://dx.doi.org/10.1016/S0378-1119(96)00691-9 DOI 10.1021/bi000856g http://dx.doi.org/10.1021/bi000856g DOI 10.1021/bi972791w http://dx.doi.org/10.1021/bi972791w DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.4.1.5 http://www.genome.jp/dbget-bin/www_bget?EC:4.4.1.5 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D86931 http://www.ebi.ac.uk/ena/data/view/D86931 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U57363 http://www.ebi.ac.uk/ena/data/view/U57363 ENZYME 4.4.1.5 http://enzyme.expasy.org/EC/4.4.1.5 EchoBASE EB3197 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3197 EcoGene EG13421 http://www.ecogene.org/geneInfo.php?eg_id=EG13421 EnsemblBacteria AAC74723 http://www.ensemblgenomes.org/id/AAC74723 EnsemblBacteria AAC74723 http://www.ensemblgenomes.org/id/AAC74723 EnsemblBacteria BAE76494 http://www.ensemblgenomes.org/id/BAE76494 EnsemblBacteria BAE76494 http://www.ensemblgenomes.org/id/BAE76494 EnsemblBacteria BAE76494 http://www.ensemblgenomes.org/id/BAE76494 EnsemblBacteria b1651 http://www.ensemblgenomes.org/id/b1651 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004462 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004462 GO_function GO:0016151 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016151 GO_process GO:0019243 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019243 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.10.180.10 http://www.cathdb.info/version/latest/superfamily/3.10.180.10 GeneID 946161 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946161 HOGENOM HOG000232011 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000232011&db=HOGENOM6 InParanoid P0AC81 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AC81 IntAct P0AC81 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AC81* IntEnz 4.4.1.5 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.4.1.5 InterPro IPR004360 http://www.ebi.ac.uk/interpro/entry/IPR004360 InterPro IPR004361 http://www.ebi.ac.uk/interpro/entry/IPR004361 InterPro IPR018146 http://www.ebi.ac.uk/interpro/entry/IPR018146 InterPro IPR029068 http://www.ebi.ac.uk/interpro/entry/IPR029068 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1643 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1643 KEGG_Gene eco:b1651 http://www.genome.jp/dbget-bin/www_bget?eco:b1651 KEGG_Orthology KO:K01759 http://www.genome.jp/dbget-bin/www_bget?KO:K01759 KEGG_Pathway ko00620 http://www.genome.jp/kegg-bin/show_pathway?ko00620 KEGG_Pathway ko04011 http://www.genome.jp/kegg-bin/show_pathway?ko04011 KEGG_Reaction rn:R02530 http://www.genome.jp/dbget-bin/www_bget?rn:R02530 MINT MINT-1255986 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1255986 OMA THNWDTP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=THNWDTP PDB 1F9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/1F9Z PDB 1FA5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1FA5 PDB 1FA6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1FA6 PDB 1FA7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1FA7 PDB 1FA8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1FA8 PDBsum 1F9Z http://www.ebi.ac.uk/pdbsum/1F9Z PDBsum 1FA5 http://www.ebi.ac.uk/pdbsum/1FA5 PDBsum 1FA6 http://www.ebi.ac.uk/pdbsum/1FA6 PDBsum 1FA7 http://www.ebi.ac.uk/pdbsum/1FA7 PDBsum 1FA8 http://www.ebi.ac.uk/pdbsum/1FA8 PROSITE PS00934 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00934 PROSITE PS00935 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00935 PSORT swissprot:LGUL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LGUL_ECOLI PSORT-B swissprot:LGUL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LGUL_ECOLI PSORT2 swissprot:LGUL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LGUL_ECOLI Pfam PF00903 http://pfam.xfam.org/family/PF00903 Phobius swissprot:LGUL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LGUL_ECOLI PhylomeDB P0AC81 http://phylomedb.org/?seqid=P0AC81 ProteinModelPortal P0AC81 http://www.proteinmodelportal.org/query/uniprot/P0AC81 PubMed 10913283 http://www.ncbi.nlm.nih.gov/pubmed/10913283 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9047352 http://www.ncbi.nlm.nih.gov/pubmed/9047352 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9628737 http://www.ncbi.nlm.nih.gov/pubmed/9628737 RefSeq NP_416168 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416168 RefSeq WP_001237796 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001237796 SMR P0AC81 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AC81 STRING 511145.b1651 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1651&targetmode=cogs STRING COG0346 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0346&targetmode=cogs SUPFAM SSF54593 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54593 TIGRFAMs TIGR00068 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00068 UniProtKB LGUL_ECOLI http://www.uniprot.org/uniprot/LGUL_ECOLI UniProtKB-AC P0AC81 http://www.uniprot.org/uniprot/P0AC81 charge swissprot:LGUL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LGUL_ECOLI eggNOG COG0346 http://eggnogapi.embl.de/nog_data/html/tree/COG0346 eggNOG ENOG4108UYE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UYE epestfind swissprot:LGUL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LGUL_ECOLI garnier swissprot:LGUL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LGUL_ECOLI helixturnhelix swissprot:LGUL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LGUL_ECOLI hmoment swissprot:LGUL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LGUL_ECOLI iep swissprot:LGUL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LGUL_ECOLI inforesidue swissprot:LGUL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LGUL_ECOLI octanol swissprot:LGUL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LGUL_ECOLI pepcoil swissprot:LGUL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LGUL_ECOLI pepdigest swissprot:LGUL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LGUL_ECOLI pepinfo swissprot:LGUL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LGUL_ECOLI pepnet swissprot:LGUL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LGUL_ECOLI pepstats swissprot:LGUL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LGUL_ECOLI pepwheel swissprot:LGUL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LGUL_ECOLI pepwindow swissprot:LGUL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LGUL_ECOLI sigcleave swissprot:LGUL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LGUL_ECOLI ## Database ID URL or Descriptions # AltName NOHA_ECOLI Putative prophage Qin DNA-packaging protein Nu1 homolog # BioGrid 4260236 133 # EcoGene EG11634 nohA # Gene3D 1.10.10.10 -; 1. # IntAct P31061 6 # InterPro IPR009061 DNA-bd_dom_put # InterPro IPR010906 Phage_lambda_Nu1_terminase-ssu # InterPro IPR011991 WHTH_DNA-bd_dom # Organism NOHA_ECOLI Escherichia coli (strain K12) # PATRIC 48662414 VBIEscCol107702_1568 # PIR G64909 G64909 # Pfam PF07471 Phage_Nu1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Prophage DNA-packing protein NohA {ECO 0000305} # RefSeq WP_000453612 NZ_CP014272.1 # SIMILARITY Belongs to the terminase small subunit family. {ECO 0000305}. # SUPFAM SSF46955 SSF46955 # eggNOG COG4220 LUCA # eggNOG ENOG4105FKG Bacteria BLAST swissprot:NOHA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NOHA_ECOLI BioCyc ECOL316407:JW1541-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1541-MONOMER BioCyc EcoCyc:EG11634-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11634-MONOMER DIP DIP-10355N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10355N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/20.13.3357 http://dx.doi.org/10.1093/nar/20.13.3357 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D00927 http://www.ebi.ac.uk/ena/data/view/D00927 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1590 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1590 EcoGene EG11634 http://www.ecogene.org/geneInfo.php?eg_id=EG11634 EnsemblBacteria BAA15252 http://www.ensemblgenomes.org/id/BAA15252 EnsemblBacteria BAA15252 http://www.ensemblgenomes.org/id/BAA15252 EnsemblBacteria BAA15252 http://www.ensemblgenomes.org/id/BAA15252 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 HOGENOM HOG000119387 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000119387&db=HOGENOM6 IntAct P31061 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31061* InterPro IPR009061 http://www.ebi.ac.uk/interpro/entry/IPR009061 InterPro IPR010906 http://www.ebi.ac.uk/interpro/entry/IPR010906 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW1541 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1541 MINT MINT-1285423 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1285423 PSORT swissprot:NOHA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NOHA_ECOLI PSORT-B swissprot:NOHA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NOHA_ECOLI PSORT2 swissprot:NOHA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NOHA_ECOLI Pfam PF07471 http://pfam.xfam.org/family/PF07471 Phobius swissprot:NOHA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NOHA_ECOLI ProteinModelPortal P31061 http://www.proteinmodelportal.org/query/uniprot/P31061 PubMed 1630906 http://www.ncbi.nlm.nih.gov/pubmed/1630906 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000453612 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000453612 SMR P31061 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31061 STRING 511145.b0560 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0560&targetmode=cogs SUPFAM SSF46955 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46955 UniProtKB NOHA_ECOLI http://www.uniprot.org/uniprot/NOHA_ECOLI UniProtKB-AC P31061 http://www.uniprot.org/uniprot/P31061 charge swissprot:NOHA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NOHA_ECOLI eggNOG COG4220 http://eggnogapi.embl.de/nog_data/html/tree/COG4220 eggNOG ENOG4105FKG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FKG epestfind swissprot:NOHA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NOHA_ECOLI garnier swissprot:NOHA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NOHA_ECOLI helixturnhelix swissprot:NOHA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NOHA_ECOLI hmoment swissprot:NOHA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NOHA_ECOLI iep swissprot:NOHA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NOHA_ECOLI inforesidue swissprot:NOHA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NOHA_ECOLI octanol swissprot:NOHA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NOHA_ECOLI pepcoil swissprot:NOHA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NOHA_ECOLI pepdigest swissprot:NOHA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NOHA_ECOLI pepinfo swissprot:NOHA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NOHA_ECOLI pepnet swissprot:NOHA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NOHA_ECOLI pepstats swissprot:NOHA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NOHA_ECOLI pepwheel swissprot:NOHA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NOHA_ECOLI pepwindow swissprot:NOHA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NOHA_ECOLI sigcleave swissprot:NOHA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NOHA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261551 7 # EcoGene EG12818 dcuD # FUNCTION DCUD_ECOLI May have a role in the transport of dicarboxylates from the periplasm across the inner membrane. Seems not to be essential for growth. It is likely to be a cryptic gene, as no or low expression has been found under a number of growth conditions and when tested with a large number of potential substrates. {ECO 0000269|PubMed 10525738}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015556 C4-dicarboxylate transmembrane transporter activity; IEA:InterPro. # GO_process GO:0006810 transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # IntAct P45428 2 # InterPro IPR004669 C4_dicarb_anaerob_car # InterPro IPR018385 C4_dicarb_anaerob_car-like # KEGG_Brite ko02000 Transporters # Organism DCUD_ECOLI Escherichia coli (strain K12) # PATRIC 32121878 VBIEscCol129921_3323 # PIR E65114 E65114 # Pfam PF03606 DcuC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DCUD_ECOLI Putative cryptic C4-dicarboxylate transporter DcuD # RefSeq NP_417694 NC_000913.3 # RefSeq WP_000467018 NZ_LN832404.1 # SIMILARITY Belongs to the DcuC/DcuD transporter (TC 2.A.61) family. {ECO 0000305}. # SUBCELLULAR LOCATION DCUD_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.61.1 the c4-dicarboxylate uptake c (dcuc) family # TIGRFAMs TIGR00771 DcuC # eggNOG COG3069 LUCA # eggNOG ENOG4105CEE Bacteria BLAST swissprot:DCUD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DCUD_ECOLI BioCyc ECOL316407:JW3196-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3196-MONOMER BioCyc EcoCyc:YHCL-MONOMER http://biocyc.org/getid?id=EcoCyc:YHCL-MONOMER COG COG3069 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3069 DIP DIP-9412N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9412N DOI 10.1007/s002030050763 http://dx.doi.org/10.1007/s002030050763 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2669 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2669 EcoGene EG12818 http://www.ecogene.org/geneInfo.php?eg_id=EG12818 EnsemblBacteria AAC76259 http://www.ensemblgenomes.org/id/AAC76259 EnsemblBacteria AAC76259 http://www.ensemblgenomes.org/id/AAC76259 EnsemblBacteria BAE77270 http://www.ensemblgenomes.org/id/BAE77270 EnsemblBacteria BAE77270 http://www.ensemblgenomes.org/id/BAE77270 EnsemblBacteria BAE77270 http://www.ensemblgenomes.org/id/BAE77270 EnsemblBacteria b3227 http://www.ensemblgenomes.org/id/b3227 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015556 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015556 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 946575 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946575 HOGENOM HOG000274996 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000274996&db=HOGENOM6 IntAct P45428 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45428* InterPro IPR004669 http://www.ebi.ac.uk/interpro/entry/IPR004669 InterPro IPR018385 http://www.ebi.ac.uk/interpro/entry/IPR018385 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3196 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3196 KEGG_Gene eco:b3227 http://www.genome.jp/dbget-bin/www_bget?eco:b3227 KEGG_Orthology KO:K03326 http://www.genome.jp/dbget-bin/www_bget?KO:K03326 OMA VFLMMCG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VFLMMCG PSORT swissprot:DCUD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DCUD_ECOLI PSORT-B swissprot:DCUD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DCUD_ECOLI PSORT2 swissprot:DCUD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DCUD_ECOLI Pfam PF03606 http://pfam.xfam.org/family/PF03606 Phobius swissprot:DCUD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DCUD_ECOLI ProteinModelPortal P45428 http://www.proteinmodelportal.org/query/uniprot/P45428 PubMed 10525738 http://www.ncbi.nlm.nih.gov/pubmed/10525738 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417694 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417694 RefSeq WP_000467018 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000467018 STRING 511145.b3227 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3227&targetmode=cogs STRING COG3069 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3069&targetmode=cogs TCDB 2.A.61.1 http://www.tcdb.org/search/result.php?tc=2.A.61.1 TIGRFAMs TIGR00771 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00771 UniProtKB DCUD_ECOLI http://www.uniprot.org/uniprot/DCUD_ECOLI UniProtKB-AC P45428 http://www.uniprot.org/uniprot/P45428 charge swissprot:DCUD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DCUD_ECOLI eggNOG COG3069 http://eggnogapi.embl.de/nog_data/html/tree/COG3069 eggNOG ENOG4105CEE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CEE epestfind swissprot:DCUD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DCUD_ECOLI garnier swissprot:DCUD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DCUD_ECOLI helixturnhelix swissprot:DCUD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DCUD_ECOLI hmoment swissprot:DCUD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DCUD_ECOLI iep swissprot:DCUD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DCUD_ECOLI inforesidue swissprot:DCUD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DCUD_ECOLI octanol swissprot:DCUD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DCUD_ECOLI pepcoil swissprot:DCUD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DCUD_ECOLI pepdigest swissprot:DCUD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DCUD_ECOLI pepinfo swissprot:DCUD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DCUD_ECOLI pepnet swissprot:DCUD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DCUD_ECOLI pepstats swissprot:DCUD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DCUD_ECOLI pepwheel swissprot:DCUD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DCUD_ECOLI pepwindow swissprot:DCUD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DCUD_ECOLI sigcleave swissprot:DCUD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DCUD_ECOLI ## Database ID URL or Descriptions # AltName DLD_ECOLI Respiratory D-lactate dehydrogenase # BRENDA 1.1.1.28 2026 # BioGrid 4260452 15 # CATALYTIC ACTIVITY DLD_ECOLI (R)-lactate + NAD(+) = pyruvate + NADH. # COFACTOR Name=FAD; Xref=ChEBI:CHEBI 57692; # DrugBank DB00756 Hexachlorophene # DrugBank DB03147 Flavin adenine dinucleotide # ENZYME REGULATION DLD_ECOLI Requires phospholipid for maximal activity. # EcoGene EG10231 dld # FUNCTION DLD_ECOLI First component of the membrane-bound D-lactate oxidase, which is believed to play an important role in the energization of the active transport of a variety of sugars and amino acids. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IEA:InterPro. # GO_component GO:0031234 extrinsic component of cytoplasmic side of plasma membrane; IDA:EcoCyc. # GO_function GO:0004458 D-lactate dehydrogenase (cytochrome) activity; IBA:GO_Central. # GO_function GO:0008720 D-lactate dehydrogenase activity; IEA:UniProtKB-EC. # GO_function GO:0009055 electron carrier activity; IDA:EcoCyc. # GO_function GO:0016901 oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor; IDA:EcoCyc. # GO_function GO:0050660 flavin adenine dinucleotide binding; IDA:EcoCyc. # GO_function GO:0051287 NAD binding; IEA:InterPro. # GO_function GO:0051990 (R)-2-hydroxyglutarate dehydrogenase activity; IBA:GO_Central. # GO_function GO:0071949 FAD binding; IBA:GO_Central. # GO_process GO:0009060 aerobic respiration; IDA:EcoCyc. # GO_process GO:0009061 anaerobic respiration; IDA:EcoCyc. # GO_process GO:0019516 lactate oxidation; IDA:EcoCyc. # GO_process GO:0022904 respiratory electron transport chain; IDA:EcoCyc. # GO_process GO:0055085 transmembrane transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0055085 transmembrane transport # Gene3D 3.30.1370.20 -; 1. # Gene3D 3.30.43.10 -; 1. # Gene3D 3.30.465.10 -; 1. # Gene3D 3.30.70.610 -; 2. # IntAct P06149 17 # InterPro IPR006094 Oxid_FAD_bind_N # InterPro IPR012256 D_lactate_DH # InterPro IPR015409 Lactate_DH_C # InterPro IPR016164 FAD-linked_Oxase-like_C # InterPro IPR016166 FAD-bd_2 # InterPro IPR016167 FAD-bd_2_sub1 # InterPro IPR016169 CO_DH_flavot_FAD-bd_sub2 # InterPro IPR016172 D-lactate_DH_C-sub1 # InterPro IPR016173 D-lactate_DH_C-sub2 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00620 Pyruvate metabolism # Organism DLD_ECOLI Escherichia coli (strain K12) # PATRIC 32119607 VBIEscCol129921_2214 # PDB 1F0X X-ray; 1.90 A; A/B=1-571 # PIR A21893 DEECDL # PIRSF PIRSF000101 D-lactate_dh # PROSITE PS51387 FAD_PCMH # Pfam PF01565 FAD_binding_4 # Pfam PF09330 Lact-deh-memb # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DLD_ECOLI D-lactate dehydrogenase # RefSeq NP_416637 NC_000913.3 # RefSeq WP_000097403 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA60530.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Contains 1 FAD-binding PCMH-type domain. {ECO:0000255|PROSITE-ProRule PRU00718}. # SUBCELLULAR LOCATION DLD_ECOLI Cell membrane; Peripheral membrane protein; Cytoplasmic side. # SUPFAM SSF55103 SSF55103 # SUPFAM SSF56176 SSF56176 # eggNOG COG0277 LUCA # eggNOG ENOG4105CXG Bacteria BLAST swissprot:DLD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DLD_ECOLI BioCyc ECOL316407:JW2121-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2121-MONOMER BioCyc EcoCyc:DLACTDEHYDROGFAD-MONOMER http://biocyc.org/getid?id=EcoCyc:DLACTDEHYDROGFAD-MONOMER BioCyc MetaCyc:DLACTDEHYDROGFAD-MONOMER http://biocyc.org/getid?id=MetaCyc:DLACTDEHYDROGFAD-MONOMER COG COG0277 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0277 DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.97.17.9413 http://dx.doi.org/10.1073/pnas.97.17.9413 DOI 10.1111/j.1432-1033.1984.tb08473.x http://dx.doi.org/10.1111/j.1432-1033.1984.tb08473.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB00756 http://www.drugbank.ca/drugs/DB00756 DrugBank DB03147 http://www.drugbank.ca/drugs/DB03147 EC_number EC:1.1.1.28 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.28 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M10038 http://www.ebi.ac.uk/ena/data/view/M10038 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X01067 http://www.ebi.ac.uk/ena/data/view/X01067 ENZYME 1.1.1.28 http://enzyme.expasy.org/EC/1.1.1.28 EchoBASE EB0227 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0227 EcoGene EG10231 http://www.ecogene.org/geneInfo.php?eg_id=EG10231 EnsemblBacteria AAC75194 http://www.ensemblgenomes.org/id/AAC75194 EnsemblBacteria AAC75194 http://www.ensemblgenomes.org/id/AAC75194 EnsemblBacteria BAE76610 http://www.ensemblgenomes.org/id/BAE76610 EnsemblBacteria BAE76610 http://www.ensemblgenomes.org/id/BAE76610 EnsemblBacteria BAE76610 http://www.ensemblgenomes.org/id/BAE76610 EnsemblBacteria b2133 http://www.ensemblgenomes.org/id/b2133 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0031234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031234 GO_function GO:0004458 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004458 GO_function GO:0008720 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008720 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0016901 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016901 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_function GO:0051287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051287 GO_function GO:0051990 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051990 GO_function GO:0071949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071949 GO_process GO:0009060 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009060 GO_process GO:0009061 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009061 GO_process GO:0019516 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019516 GO_process GO:0022904 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022904 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 3.30.1370.20 http://www.cathdb.info/version/latest/superfamily/3.30.1370.20 Gene3D 3.30.43.10 http://www.cathdb.info/version/latest/superfamily/3.30.43.10 Gene3D 3.30.465.10 http://www.cathdb.info/version/latest/superfamily/3.30.465.10 Gene3D 3.30.70.610 http://www.cathdb.info/version/latest/superfamily/3.30.70.610 GeneID 946653 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946653 HOGENOM HOG000122232 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122232&db=HOGENOM6 InParanoid P06149 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P06149 IntAct P06149 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P06149* IntEnz 1.1.1.28 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.28 InterPro IPR006094 http://www.ebi.ac.uk/interpro/entry/IPR006094 InterPro IPR012256 http://www.ebi.ac.uk/interpro/entry/IPR012256 InterPro IPR015409 http://www.ebi.ac.uk/interpro/entry/IPR015409 InterPro IPR016164 http://www.ebi.ac.uk/interpro/entry/IPR016164 InterPro IPR016166 http://www.ebi.ac.uk/interpro/entry/IPR016166 InterPro IPR016167 http://www.ebi.ac.uk/interpro/entry/IPR016167 InterPro IPR016169 http://www.ebi.ac.uk/interpro/entry/IPR016169 InterPro IPR016172 http://www.ebi.ac.uk/interpro/entry/IPR016172 InterPro IPR016173 http://www.ebi.ac.uk/interpro/entry/IPR016173 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2121 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2121 KEGG_Gene eco:b2133 http://www.genome.jp/dbget-bin/www_bget?eco:b2133 KEGG_Orthology KO:K03777 http://www.genome.jp/dbget-bin/www_bget?KO:K03777 KEGG_Pathway ko00620 http://www.genome.jp/kegg-bin/show_pathway?ko00620 KEGG_Reaction rn:R00704 http://www.genome.jp/dbget-bin/www_bget?rn:R00704 OMA RDRYEHH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RDRYEHH PDB 1F0X http://www.ebi.ac.uk/pdbe-srv/view/entry/1F0X PDBsum 1F0X http://www.ebi.ac.uk/pdbsum/1F0X PROSITE PS51387 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51387 PSORT swissprot:DLD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DLD_ECOLI PSORT-B swissprot:DLD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DLD_ECOLI PSORT2 swissprot:DLD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DLD_ECOLI Pfam PF01565 http://pfam.xfam.org/family/PF01565 Pfam PF09330 http://pfam.xfam.org/family/PF09330 Phobius swissprot:DLD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DLD_ECOLI ProteinModelPortal P06149 http://www.proteinmodelportal.org/query/uniprot/P06149 PubMed 10944213 http://www.ncbi.nlm.nih.gov/pubmed/10944213 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3882663 http://www.ncbi.nlm.nih.gov/pubmed/3882663 PubMed 6386470 http://www.ncbi.nlm.nih.gov/pubmed/6386470 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_416637 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416637 RefSeq WP_000097403 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000097403 SMR P06149 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P06149 STRING 511145.b2133 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2133&targetmode=cogs STRING COG0277 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0277&targetmode=cogs SUPFAM SSF55103 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55103 SUPFAM SSF56176 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56176 UniProtKB DLD_ECOLI http://www.uniprot.org/uniprot/DLD_ECOLI UniProtKB-AC P06149 http://www.uniprot.org/uniprot/P06149 charge swissprot:DLD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DLD_ECOLI eggNOG COG0277 http://eggnogapi.embl.de/nog_data/html/tree/COG0277 eggNOG ENOG4105CXG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CXG epestfind swissprot:DLD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DLD_ECOLI garnier swissprot:DLD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DLD_ECOLI helixturnhelix swissprot:DLD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DLD_ECOLI hmoment swissprot:DLD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DLD_ECOLI iep swissprot:DLD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DLD_ECOLI inforesidue swissprot:DLD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DLD_ECOLI octanol swissprot:DLD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DLD_ECOLI pepcoil swissprot:DLD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DLD_ECOLI pepdigest swissprot:DLD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DLD_ECOLI pepinfo swissprot:DLD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DLD_ECOLI pepnet swissprot:DLD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DLD_ECOLI pepstats swissprot:DLD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DLD_ECOLI pepwheel swissprot:DLD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DLD_ECOLI pepwindow swissprot:DLD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DLD_ECOLI sigcleave swissprot:DLD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DLD_ECOLI ## Database ID URL or Descriptions # AltName YADI_ECOLI Putative PTS system EIIA component # CATALYTIC ACTIVITY YADI_ECOLI Protein EIIA N(pi)-phospho-L-histidine + protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L- histidine/cysteine. # CDD cd00006 PTS_IIA_man # DOMAIN YADI_ECOLI The EIIA domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the EIIB domain. # EcoGene EG12322 yadI # FUNCTION YADI_ECOLI The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. {ECO 0000250}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:InterPro. # GO_function GO:0016301 kinase activity; IEA:UniProtKB-KW. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016301 kinase activity # GOslim_process GO:0006810 transport # Gene3D 3.40.50.510 -; 1. # InterPro IPR004701 PTS_EIIA_man-typ # InterPro IPR033887 PTS_IIA_man # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00283 PTS system, ascorbate-specific II component # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko00053 Ascorbate and aldarate metabolism # KEGG_Pathway ko02060 Phosphotransferase system (PTS) # Organism YADI_ECOLI Escherichia coli (strain K12) # PATRIC 32115361 VBIEscCol129921_0132 # PIR A64736 A64736 # PROSITE PS51096 PTS_EIIA_TYPE_4 # Pfam PF03610 EIIA-man # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YADI_ECOLI Putative phosphotransferase enzyme IIA component YadI # RefSeq NP_414671 NC_000913.3 # RefSeq WP_000901987 NZ_LN832404.1 # SIMILARITY Contains 1 PTS EIIA type-4 domain. {ECO:0000255|PROSITE-ProRule PRU00419}. # SUBCELLULAR LOCATION YADI_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF53062 SSF53062 # eggNOG COG2893 LUCA # eggNOG ENOG4108YTN Bacteria BLAST swissprot:YADI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YADI_ECOLI BioCyc ECOL316407:JW0125-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0125-MONOMER BioCyc EcoCyc:AGAX-MONOMER http://biocyc.org/getid?id=EcoCyc:AGAX-MONOMER BioCyc MetaCyc:AGAX-MONOMER http://biocyc.org/getid?id=MetaCyc:AGAX-MONOMER COG COG1762 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1762 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.- http://enzyme.expasy.org/EC/2.7.1.- EchoBASE EB2227 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2227 EcoGene EG12322 http://www.ecogene.org/geneInfo.php?eg_id=EG12322 EnsemblBacteria AAC73240 http://www.ensemblgenomes.org/id/AAC73240 EnsemblBacteria AAC73240 http://www.ensemblgenomes.org/id/AAC73240 EnsemblBacteria BAB96706 http://www.ensemblgenomes.org/id/BAB96706 EnsemblBacteria BAB96706 http://www.ensemblgenomes.org/id/BAB96706 EnsemblBacteria BAB96706 http://www.ensemblgenomes.org/id/BAB96706 EnsemblBacteria b0129 http://www.ensemblgenomes.org/id/b0129 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.40.50.510 http://www.cathdb.info/version/latest/superfamily/3.40.50.510 GeneID 947397 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947397 HOGENOM HOG000095324 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000095324&db=HOGENOM6 InParanoid P36881 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P36881 IntEnz 2.7.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1 InterPro IPR004701 http://www.ebi.ac.uk/interpro/entry/IPR004701 InterPro IPR033887 http://www.ebi.ac.uk/interpro/entry/IPR033887 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0125 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0125 KEGG_Gene eco:b0129 http://www.genome.jp/dbget-bin/www_bget?eco:b0129 KEGG_Orthology KO:K02821 http://www.genome.jp/dbget-bin/www_bget?KO:K02821 KEGG_Pathway ko00053 http://www.genome.jp/kegg-bin/show_pathway?ko00053 KEGG_Pathway ko02060 http://www.genome.jp/kegg-bin/show_pathway?ko02060 KEGG_Reaction rn:R07671 http://www.genome.jp/dbget-bin/www_bget?rn:R07671 OMA LPLRESM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LPLRESM PROSITE PS51096 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51096 PSORT swissprot:YADI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YADI_ECOLI PSORT-B swissprot:YADI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YADI_ECOLI PSORT2 swissprot:YADI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YADI_ECOLI Pfam PF03610 http://pfam.xfam.org/family/PF03610 Phobius swissprot:YADI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YADI_ECOLI PhylomeDB P36881 http://phylomedb.org/?seqid=P36881 ProteinModelPortal P36881 http://www.proteinmodelportal.org/query/uniprot/P36881 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414671 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414671 RefSeq WP_000901987 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000901987 SMR P36881 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P36881 STRING 511145.b0129 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0129&targetmode=cogs STRING COG1762 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1762&targetmode=cogs SUPFAM SSF53062 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53062 UniProtKB YADI_ECOLI http://www.uniprot.org/uniprot/YADI_ECOLI UniProtKB-AC P36881 http://www.uniprot.org/uniprot/P36881 charge swissprot:YADI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YADI_ECOLI eggNOG COG2893 http://eggnogapi.embl.de/nog_data/html/tree/COG2893 eggNOG ENOG4108YTN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108YTN epestfind swissprot:YADI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YADI_ECOLI garnier swissprot:YADI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YADI_ECOLI helixturnhelix swissprot:YADI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YADI_ECOLI hmoment swissprot:YADI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YADI_ECOLI iep swissprot:YADI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YADI_ECOLI inforesidue swissprot:YADI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YADI_ECOLI octanol swissprot:YADI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YADI_ECOLI pepcoil swissprot:YADI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YADI_ECOLI pepdigest swissprot:YADI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YADI_ECOLI pepinfo swissprot:YADI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YADI_ECOLI pepnet swissprot:YADI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YADI_ECOLI pepstats swissprot:YADI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YADI_ECOLI pepwheel swissprot:YADI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YADI_ECOLI pepwindow swissprot:YADI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YADI_ECOLI sigcleave swissprot:YADI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YADI_ECOLI ## Database ID URL or Descriptions # BioGrid 4262614 3 # EcoGene EG11464 yigF # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GOslim_component GO:0005886 plasma membrane # InterPro IPR024399 DUF2628 # Organism YIGF_ECOLI Escherichia coli (strain K12) # PATRIC 32123135 VBIEscCol129921_3933 # PIR S30707 S30707 # Pfam PF10947 DUF2628 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIGF_ECOLI Uncharacterized protein YigF # RefSeq NP_418261 NC_000913.3 # RefSeq WP_000032581 NZ_LN832404.1 # eggNOG ENOG4105NRM Bacteria # eggNOG ENOG4111WY1 LUCA BLAST swissprot:YIGF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIGF_ECOLI BioCyc ECOL316407:JW3790-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3790-MONOMER BioCyc EcoCyc:EG11464-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11464-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L02122 http://www.ebi.ac.uk/ena/data/view/L02122 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1432 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1432 EcoGene EG11464 http://www.ecogene.org/geneInfo.php?eg_id=EG11464 EnsemblBacteria AAC76820 http://www.ensemblgenomes.org/id/AAC76820 EnsemblBacteria AAC76820 http://www.ensemblgenomes.org/id/AAC76820 EnsemblBacteria BAE77484 http://www.ensemblgenomes.org/id/BAE77484 EnsemblBacteria BAE77484 http://www.ensemblgenomes.org/id/BAE77484 EnsemblBacteria BAE77484 http://www.ensemblgenomes.org/id/BAE77484 EnsemblBacteria b3817 http://www.ensemblgenomes.org/id/b3817 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 948340 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948340 HOGENOM HOG000224781 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000224781&db=HOGENOM6 InterPro IPR024399 http://www.ebi.ac.uk/interpro/entry/IPR024399 KEGG_Gene ecj:JW3790 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3790 KEGG_Gene eco:b3817 http://www.genome.jp/dbget-bin/www_bget?eco:b3817 OMA WKKNLAL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WKKNLAL PSORT swissprot:YIGF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIGF_ECOLI PSORT-B swissprot:YIGF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIGF_ECOLI PSORT2 swissprot:YIGF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIGF_ECOLI Pfam PF10947 http://pfam.xfam.org/family/PF10947 Phobius swissprot:YIGF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIGF_ECOLI ProteinModelPortal P27842 http://www.proteinmodelportal.org/query/uniprot/P27842 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418261 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418261 RefSeq WP_000032581 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000032581 STRING 511145.b3817 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3817&targetmode=cogs UniProtKB YIGF_ECOLI http://www.uniprot.org/uniprot/YIGF_ECOLI UniProtKB-AC P27842 http://www.uniprot.org/uniprot/P27842 charge swissprot:YIGF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIGF_ECOLI eggNOG ENOG4105NRM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105NRM eggNOG ENOG4111WY1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111WY1 epestfind swissprot:YIGF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIGF_ECOLI garnier swissprot:YIGF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIGF_ECOLI helixturnhelix swissprot:YIGF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIGF_ECOLI hmoment swissprot:YIGF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIGF_ECOLI iep swissprot:YIGF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIGF_ECOLI inforesidue swissprot:YIGF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIGF_ECOLI octanol swissprot:YIGF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIGF_ECOLI pepcoil swissprot:YIGF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIGF_ECOLI pepdigest swissprot:YIGF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIGF_ECOLI pepinfo swissprot:YIGF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIGF_ECOLI pepnet swissprot:YIGF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIGF_ECOLI pepstats swissprot:YIGF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIGF_ECOLI pepwheel swissprot:YIGF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIGF_ECOLI pepwindow swissprot:YIGF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIGF_ECOLI sigcleave swissprot:YIGF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIGF_ECOLI ## Database ID URL or Descriptions # BioGrid 4263105 9 # DISRUPTION PHENOTYPE Deletion increases biofilm formation. {ECO:0000269|PubMed 17765265}. # EcoGene EG14290 ariR # FUNCTION ARIR_ECOLI Probably a connector protein for RcsB/C regulation of biofilm and acid-resistance, providing additional signal input into the two-component signaling pathway. May serve to stimulate biofilm maturation, via the Rcs phosphorelay. Regulates expression of genes involved in acid-resistance and biofilm formation, including the RcsB/C two-component system. May be a non-specific DNA-binding protein that binds genes and/or intergenic regions via a geometric recognition. Also confers resistance to H(2)O(2). Overexpression at 28 and 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB; AriR probably acts upstream of the RcsB/C system to stimulate the activity and not transcription of RcsB/C. 5-fluorouracil reduction in biofilm formation requires this protein. {ECO 0000269|PubMed 17765265}. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_process GO:0042542 response to hydrogen peroxide; IMP:EcoCyc. # GO_process GO:0044010 single-species biofilm formation; IMP:EcoCyc. # GO_process GO:0071229 cellular response to acid chemical; IEA:InterPro. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # INDUCTION ARIR_ECOLI Induced by low temperature (23 degrees Celsius). Repressed by the autoinducer-2 (AI-2) and by indole. Induced by 5- fluorouracil. Strongly induced at 16 degrees Celsius. Expression has been shown to be independent of RpoS (PubMed 18174134) and dependent on RpoS (PubMed 19240136), repressed by YcgE. At 16 degrees Celsius with blue light irradiation expression of this operon is absolutely dependent on YcgF for relief of YcgE repression. Part of the ycgZ-ymgA-ariR-ymgC operon, it probably also has its own promoter. {ECO 0000269|PubMed 15470704, ECO 0000269|PubMed 17511876, ECO 0000269|PubMed 18174134, ECO 0000269|PubMed 19172264, ECO 0000269|PubMed 19240136}. # InterPro IPR024753 AriR # Organism ARIR_ECOLI Escherichia coli (strain K12) # PATRIC 32117567 VBIEscCol129921_1206 # PDB 2OXL X-ray; 1.80 A; A/B=25-88 # PIR C64862 C64862 # Pfam PF10798 YmgB # ProDom PD865043 PD865043 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ARIR_ECOLI Probable two-component-system connector protein AriR # RefSeq NP_415684 NC_000913.3 # RefSeq WP_000888772 NZ_LN832404.1 # SIMILARITY Belongs to the AriR family. {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 17765265}. # eggNOG ENOG4106E9H Bacteria # eggNOG ENOG410Y1T2 LUCA BLAST swissprot:ARIR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARIR_ECOLI BioCyc ECOL316407:JW1153-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1153-MONOMER BioCyc EcoCyc:G6606-MONOMER http://biocyc.org/getid?id=EcoCyc:G6606-MONOMER DOI 10.1002/bit.20259 http://dx.doi.org/10.1002/bit.20259 DOI 10.1007/s00253-009-1860-8 http://dx.doi.org/10.1007/s00253-009-1860-8 DOI 10.1016/j.jmb.2007.07.037 http://dx.doi.org/10.1016/j.jmb.2007.07.037 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1099/mic.0.2007/012021-0 http://dx.doi.org/10.1099/mic.0.2007/012021-0 DOI 10.1101/gad.499409 http://dx.doi.org/10.1101/gad.499409 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1186/1471-2180-7-42 http://dx.doi.org/10.1186/1471-2180-7-42 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4038 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4038 EcoGene EG14290 http://www.ecogene.org/geneInfo.php?eg_id=EG14290 EnsemblBacteria AAC74250 http://www.ensemblgenomes.org/id/AAC74250 EnsemblBacteria AAC74250 http://www.ensemblgenomes.org/id/AAC74250 EnsemblBacteria BAE76387 http://www.ensemblgenomes.org/id/BAE76387 EnsemblBacteria BAE76387 http://www.ensemblgenomes.org/id/BAE76387 EnsemblBacteria BAE76387 http://www.ensemblgenomes.org/id/BAE76387 EnsemblBacteria b1166 http://www.ensemblgenomes.org/id/b1166 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0042542 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042542 GO_process GO:0044010 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044010 GO_process GO:0071229 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071229 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 945340 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945340 HOGENOM HOG000267903 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267903&db=HOGENOM6 IntAct P75993 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75993* InterPro IPR024753 http://www.ebi.ac.uk/interpro/entry/IPR024753 KEGG_Gene ecj:JW1153 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1153 KEGG_Gene eco:b1166 http://www.genome.jp/dbget-bin/www_bget?eco:b1166 OMA DEFHIEL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DEFHIEL PDB 2OXL http://www.ebi.ac.uk/pdbe-srv/view/entry/2OXL PDBsum 2OXL http://www.ebi.ac.uk/pdbsum/2OXL PSORT swissprot:ARIR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARIR_ECOLI PSORT-B swissprot:ARIR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARIR_ECOLI PSORT2 swissprot:ARIR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARIR_ECOLI Pfam PF10798 http://pfam.xfam.org/family/PF10798 Phobius swissprot:ARIR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARIR_ECOLI ProteinModelPortal P75993 http://www.proteinmodelportal.org/query/uniprot/P75993 PubMed 15470704 http://www.ncbi.nlm.nih.gov/pubmed/15470704 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17511876 http://www.ncbi.nlm.nih.gov/pubmed/17511876 PubMed 17765265 http://www.ncbi.nlm.nih.gov/pubmed/17765265 PubMed 18174134 http://www.ncbi.nlm.nih.gov/pubmed/18174134 PubMed 19172264 http://www.ncbi.nlm.nih.gov/pubmed/19172264 PubMed 19240136 http://www.ncbi.nlm.nih.gov/pubmed/19240136 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415684 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415684 RefSeq WP_000888772 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000888772 SMR P75993 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75993 STRING 511145.b1166 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1166&targetmode=cogs UniProtKB ARIR_ECOLI http://www.uniprot.org/uniprot/ARIR_ECOLI UniProtKB-AC P75993 http://www.uniprot.org/uniprot/P75993 charge swissprot:ARIR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARIR_ECOLI eggNOG ENOG4106E9H http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106E9H eggNOG ENOG410Y1T2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y1T2 epestfind swissprot:ARIR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARIR_ECOLI garnier swissprot:ARIR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARIR_ECOLI helixturnhelix swissprot:ARIR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARIR_ECOLI hmoment swissprot:ARIR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARIR_ECOLI iep swissprot:ARIR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARIR_ECOLI inforesidue swissprot:ARIR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARIR_ECOLI octanol swissprot:ARIR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARIR_ECOLI pepcoil swissprot:ARIR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARIR_ECOLI pepdigest swissprot:ARIR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARIR_ECOLI pepinfo swissprot:ARIR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARIR_ECOLI pepnet swissprot:ARIR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARIR_ECOLI pepstats swissprot:ARIR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARIR_ECOLI pepwheel swissprot:ARIR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARIR_ECOLI pepwindow swissprot:ARIR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARIR_ECOLI sigcleave swissprot:ARIR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARIR_ECOLI ## Database ID URL or Descriptions # AltName Two-histidine 2',3'-cyclic phosphodiesterase acting on RNA {ECO:0000303|PubMed 25239919} # BRENDA 6.5.1.B1 2026 # BioGrid 4259744 107 # CAUTION THPR_ECOLI Was originally thought to be a 2',5'-RNA ligase. {ECO 0000305|PubMed 6347395, ECO 0000305|PubMed 8940112}. # DISRUPTION PHENOTYPE Disruption abolishes ligase activity in cell lysates, but mutants grow normally under laboratory conditions. {ECO:0000269|PubMed 8940112}. # EcoGene EG12330 thpR # FUNCTION THPR_ECOLI Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester (PubMed 25239919). In vitro, can also ligate 5' and 3' half-tRNA molecules with 2',3'-cyclic phosphate and 5'- hydroxyl termini, respectively, to the product containing the 2'- 5' phosphodiester linkage. This reaction does not require ATP and is reversible (PubMed 6347395 and PubMed 8940112). {ECO 0000269|PubMed 25239919, ECO 0000269|PubMed 6347395, ECO 0000269|PubMed 8940112}. # GO_function GO:0004113 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity; IDA:EcoCyc. # GO_function GO:0008664 2'-5'-RNA ligase activity; IDA:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016874 ligase activity # Gene3D 3.90.1140.10 -; 1. # HAMAP MF_01940 RNA_CPDase # InterPro IPR004175 RNA_CPDase # InterPro IPR009097 RNA_ligase/cNuc_Pdiesterase # InterPro IPR014051 Phosphoesterase_HXTX # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # Organism THPR_ECOLI Escherichia coli (strain K12) # PATRIC 32115401 VBIEscCol129921_0152 # PDB 4QAK X-ray; 2.02 A; A/B=1-176 # PIR C64738 C64738 # Pfam PF02834 LigT_PEase; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName THPR_ECOLI RNA 2',3'-cyclic phosphodiesterase {ECO 0000255|HAMAP-Rule MF_01940, ECO 0000303|PubMed 25239919} # RefSeq NP_414689 NC_000913.3 # RefSeq WP_001294700 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=M60726; Type=Frameshift; Positions=168; Evidence={ECO 0000305}; # SIMILARITY Belongs to the 2H phosphoesterase superfamily. ThpR family. {ECO:0000255|HAMAP-Rule MF_01940, ECO:0000305}. # SUBUNIT Monomer. {ECO:0000269|PubMed 25239919}. # SUPFAM SSF55144 SSF55144 # TIGRFAMs TIGR02258 2_5_ligase # eggNOG COG1514 LUCA # eggNOG ENOG4107XID Bacteria BLAST swissprot:THPR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:THPR_ECOLI BioCyc ECOL316407:JW5011-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5011-MONOMER BioCyc EcoCyc:EG12330-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12330-MONOMER BioCyc MetaCyc:EG12330-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12330-MONOMER COG COG1514 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1514 DOI 10.1016/0092-8674(83)90032-6 http://dx.doi.org/10.1016/0092-8674(83)90032-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.271.49.31145 http://dx.doi.org/10.1074/jbc.271.49.31145 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1261/rna.046797.114 http://dx.doi.org/10.1261/rna.046797.114 EC_number EC:3.1.4.- {ECO:0000255|HAMAP-Rule:MF_01940, ECO:0000269|PubMed:25239919} http://www.genome.jp/dbget-bin/www_bget?EC:3.1.4.- {ECO:0000255|HAMAP-Rule:MF_01940, ECO:0000269|PubMed:25239919} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M60726 http://www.ebi.ac.uk/ena/data/view/M60726 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.4.- {ECO:0000255|HAMAP-Rule:MF_01940, ECO:0000269|PubMed:25239919} http://enzyme.expasy.org/EC/3.1.4.- {ECO:0000255|HAMAP-Rule:MF_01940, ECO:0000269|PubMed:25239919} EchoBASE EB2234 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2234 EcoGene EG12330 http://www.ecogene.org/geneInfo.php?eg_id=EG12330 EnsemblBacteria AAC73258 http://www.ensemblgenomes.org/id/AAC73258 EnsemblBacteria AAC73258 http://www.ensemblgenomes.org/id/AAC73258 EnsemblBacteria BAB96724 http://www.ensemblgenomes.org/id/BAB96724 EnsemblBacteria BAB96724 http://www.ensemblgenomes.org/id/BAB96724 EnsemblBacteria BAB96724 http://www.ensemblgenomes.org/id/BAB96724 EnsemblBacteria b0147 http://www.ensemblgenomes.org/id/b0147 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004113 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004113 GO_function GO:0008664 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008664 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 Gene3D 3.90.1140.10 http://www.cathdb.info/version/latest/superfamily/3.90.1140.10 GeneID 944848 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944848 HAMAP MF_01940 http://hamap.expasy.org/unirule/MF_01940 HOGENOM HOG000226389 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000226389&db=HOGENOM6 InParanoid P37025 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37025 IntEnz 3.1.4.- {ECO:0000255|HAMAP-Rule:MF_01940, ECO:0000269|PubMed:25239919} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.4.- {ECO:0000255|HAMAP-Rule:MF_01940, ECO:0000269|PubMed:25239919} InterPro IPR004175 http://www.ebi.ac.uk/interpro/entry/IPR004175 InterPro IPR009097 http://www.ebi.ac.uk/interpro/entry/IPR009097 InterPro IPR014051 http://www.ebi.ac.uk/interpro/entry/IPR014051 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW5011 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5011 KEGG_Gene eco:b0147 http://www.genome.jp/dbget-bin/www_bget?eco:b0147 KEGG_Orthology KO:K01975 http://www.genome.jp/dbget-bin/www_bget?KO:K01975 OMA GVVWLGC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GVVWLGC PDB 4QAK http://www.ebi.ac.uk/pdbe-srv/view/entry/4QAK PDBsum 4QAK http://www.ebi.ac.uk/pdbsum/4QAK PSORT swissprot:THPR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:THPR_ECOLI PSORT-B swissprot:THPR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:THPR_ECOLI PSORT2 swissprot:THPR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:THPR_ECOLI Pfam PF02834 http://pfam.xfam.org/family/PF02834 Phobius swissprot:THPR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:THPR_ECOLI PhylomeDB P37025 http://phylomedb.org/?seqid=P37025 ProteinModelPortal P37025 http://www.proteinmodelportal.org/query/uniprot/P37025 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2013578 http://www.ncbi.nlm.nih.gov/pubmed/2013578 PubMed 25239919 http://www.ncbi.nlm.nih.gov/pubmed/25239919 PubMed 6347395 http://www.ncbi.nlm.nih.gov/pubmed/6347395 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 8940112 http://www.ncbi.nlm.nih.gov/pubmed/8940112 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414689 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414689 RefSeq WP_001294700 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001294700 SMR P37025 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37025 STRING 511145.b0147 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0147&targetmode=cogs STRING COG1514 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1514&targetmode=cogs SUPFAM SSF55144 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55144 TIGRFAMs TIGR02258 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02258 UniProtKB THPR_ECOLI http://www.uniprot.org/uniprot/THPR_ECOLI UniProtKB-AC P37025 http://www.uniprot.org/uniprot/P37025 charge swissprot:THPR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:THPR_ECOLI eggNOG COG1514 http://eggnogapi.embl.de/nog_data/html/tree/COG1514 eggNOG ENOG4107XID http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107XID epestfind swissprot:THPR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:THPR_ECOLI garnier swissprot:THPR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:THPR_ECOLI helixturnhelix swissprot:THPR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:THPR_ECOLI hmoment swissprot:THPR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:THPR_ECOLI iep swissprot:THPR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:THPR_ECOLI inforesidue swissprot:THPR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:THPR_ECOLI octanol swissprot:THPR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:THPR_ECOLI pepcoil swissprot:THPR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:THPR_ECOLI pepdigest swissprot:THPR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:THPR_ECOLI pepinfo swissprot:THPR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:THPR_ECOLI pepnet swissprot:THPR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:THPR_ECOLI pepstats swissprot:THPR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:THPR_ECOLI pepwheel swissprot:THPR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:THPR_ECOLI pepwindow swissprot:THPR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:THPR_ECOLI sigcleave swissprot:THPR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:THPR_ECOLI ## Database ID URL or Descriptions # AltName RSMF_ECOLI 16S rRNA m5C1407 methyltransferase # AltName RSMF_ECOLI rRNA (cytosine-C(5)-)-methyltransferase RsmF # BRENDA 2.1.1.178 2026 # BioGrid 4259158 9 # CATALYTIC ACTIVITY RSMF_ECOLI S-adenosyl-L-methionine + cytosine(1407) in 16S rRNA = S-adenosyl-L-homocysteine + 5-methylcytosine(1407) in 16S rRNA. {ECO 0000269|PubMed 16678201, ECO 0000269|PubMed 16793063}. # EcoGene EG14023 rsmF # FUNCTION RSMF_ECOLI Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA. {ECO 0000269|PubMed 16678201}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003723 RNA binding; IEA:UniProtKB-KW. # GO_function GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity; IDA:EcoCyc. # GO_process GO:0070475 rRNA base methylation; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.50.150 -; 1. # HAMAP MF_01579 16SrRNA_methyltr_F # InterPro IPR001678 MeTrfase_RsmB/NOP2 # InterPro IPR011023 Nop2p # InterPro IPR018314 Fmu/NOL1/Nop2p_CS # InterPro IPR023267 RCMT # InterPro IPR023545 rRNA_ssu_MeTfrase_F # InterPro IPR027391 Nol1_Nop2_Fmu_2 # InterPro IPR029063 SAM-dependent_MTases # InterPro IPR031341 Methyltr_RsmF_N # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # Organism RSMF_ECOLI Escherichia coli (strain K12) # PATRIC 32118991 VBIEscCol129921_1913 # PDB 2FRX X-ray; 2.90 A; A/B/C/D=1-479 # PIR C64945 C64945 # PRINTS PR02008 RCMTFAMILY # PROSITE PS01153 NOL1_NOP2_SUN # PROSITE PS51686 SAM_MT_RSMB_NOP # Pfam PF01189 Methyltr_RsmB-F # Pfam PF13636 Methyltranf_PUA # Pfam PF17125 Methyltr_RsmF_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RSMF_ECOLI Ribosomal RNA small subunit methyltransferase F # RefSeq NP_416349 NC_000913.3 # RefSeq WP_001352260 NZ_LN832404.1 # SIMILARITY Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. {ECO 0000305}. # SUBCELLULAR LOCATION RSMF_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF53335 SSF53335 # TIGRFAMs TIGR00446 nop2p # eggNOG COG0144 LUCA # eggNOG COG3270 LUCA # eggNOG ENOG4105CYJ Bacteria BLAST swissprot:RSMF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RSMF_ECOLI BioCyc ECOL316407:JW5301-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5301-MONOMER BioCyc EcoCyc:G7008-MONOMER http://biocyc.org/getid?id=EcoCyc:G7008-MONOMER BioCyc MetaCyc:G7008-MONOMER http://biocyc.org/getid?id=MetaCyc:G7008-MONOMER COG COG0144 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0144 DOI 10.1016/j.jmb.2006.04.007 http://dx.doi.org/10.1016/j.jmb.2006.04.007 DOI 10.1016/j.jmb.2006.05.047 http://dx.doi.org/10.1016/j.jmb.2006.05.047 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.1.178 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.178 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.1.1.178 http://enzyme.expasy.org/EC/2.1.1.178 EchoBASE EB3777 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3777 EcoGene EG14023 http://www.ecogene.org/geneInfo.php?eg_id=EG14023 EnsemblBacteria AAC74905 http://www.ensemblgenomes.org/id/AAC74905 EnsemblBacteria AAC74905 http://www.ensemblgenomes.org/id/AAC74905 EnsemblBacteria BAA15648 http://www.ensemblgenomes.org/id/BAA15648 EnsemblBacteria BAA15648 http://www.ensemblgenomes.org/id/BAA15648 EnsemblBacteria BAA15648 http://www.ensemblgenomes.org/id/BAA15648 EnsemblBacteria b1835 http://www.ensemblgenomes.org/id/b1835 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0009383 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009383 GO_process GO:0070475 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070475 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 GeneID 946348 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946348 HAMAP MF_01579 http://hamap.expasy.org/unirule/MF_01579 HOGENOM HOG000218115 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218115&db=HOGENOM6 InParanoid P76273 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76273 IntEnz 2.1.1.178 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.178 InterPro IPR001678 http://www.ebi.ac.uk/interpro/entry/IPR001678 InterPro IPR011023 http://www.ebi.ac.uk/interpro/entry/IPR011023 InterPro IPR018314 http://www.ebi.ac.uk/interpro/entry/IPR018314 InterPro IPR023267 http://www.ebi.ac.uk/interpro/entry/IPR023267 InterPro IPR023545 http://www.ebi.ac.uk/interpro/entry/IPR023545 InterPro IPR027391 http://www.ebi.ac.uk/interpro/entry/IPR027391 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 InterPro IPR031341 http://www.ebi.ac.uk/interpro/entry/IPR031341 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW5301 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5301 KEGG_Gene eco:b1835 http://www.genome.jp/dbget-bin/www_bget?eco:b1835 KEGG_Orthology KO:K11392 http://www.genome.jp/dbget-bin/www_bget?KO:K11392 OMA WCAEGFW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WCAEGFW PDB 2FRX http://www.ebi.ac.uk/pdbe-srv/view/entry/2FRX PDBsum 2FRX http://www.ebi.ac.uk/pdbsum/2FRX PRINTS PR02008 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR02008 PROSITE PS01153 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01153 PROSITE PS51686 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51686 PSORT swissprot:RSMF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RSMF_ECOLI PSORT-B swissprot:RSMF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RSMF_ECOLI PSORT2 swissprot:RSMF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RSMF_ECOLI Pfam PF01189 http://pfam.xfam.org/family/PF01189 Pfam PF13636 http://pfam.xfam.org/family/PF13636 Pfam PF17125 http://pfam.xfam.org/family/PF17125 Phobius swissprot:RSMF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RSMF_ECOLI PhylomeDB P76273 http://phylomedb.org/?seqid=P76273 ProteinModelPortal P76273 http://www.proteinmodelportal.org/query/uniprot/P76273 PubMed 16678201 http://www.ncbi.nlm.nih.gov/pubmed/16678201 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16793063 http://www.ncbi.nlm.nih.gov/pubmed/16793063 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416349 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416349 RefSeq WP_001352260 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001352260 SMR P76273 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76273 STRING 511145.b1835 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1835&targetmode=cogs STRING COG0144 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0144&targetmode=cogs SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 TIGRFAMs TIGR00446 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00446 UniProtKB RSMF_ECOLI http://www.uniprot.org/uniprot/RSMF_ECOLI UniProtKB-AC P76273 http://www.uniprot.org/uniprot/P76273 charge swissprot:RSMF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RSMF_ECOLI eggNOG COG0144 http://eggnogapi.embl.de/nog_data/html/tree/COG0144 eggNOG COG3270 http://eggnogapi.embl.de/nog_data/html/tree/COG3270 eggNOG ENOG4105CYJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CYJ epestfind swissprot:RSMF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RSMF_ECOLI garnier swissprot:RSMF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RSMF_ECOLI helixturnhelix swissprot:RSMF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RSMF_ECOLI hmoment swissprot:RSMF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RSMF_ECOLI iep swissprot:RSMF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RSMF_ECOLI inforesidue swissprot:RSMF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RSMF_ECOLI octanol swissprot:RSMF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RSMF_ECOLI pepcoil swissprot:RSMF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RSMF_ECOLI pepdigest swissprot:RSMF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RSMF_ECOLI pepinfo swissprot:RSMF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RSMF_ECOLI pepnet swissprot:RSMF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RSMF_ECOLI pepstats swissprot:RSMF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RSMF_ECOLI pepwheel swissprot:RSMF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RSMF_ECOLI pepwindow swissprot:RSMF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RSMF_ECOLI sigcleave swissprot:RSMF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RSMF_ECOLI ## Database ID URL or Descriptions # AltName X19F_ECOLI ORF 19 # AltName X19F_ECOLI ORF169 # AltName X19F_ECOLI P19 protein # InterPro IPR008258 Transglycosylase_SLT_dom_1 # InterPro IPR023346 Lysozyme-like_dom # Organism X19F_ECOLI Escherichia coli (strain K12) # PIR S07015 S07015 # Pfam PF01464 SLT # RecName X19F_ECOLI X polypeptide # RefSeq NP_061449 NC_002483.1 # RefSeq WP_000759160 NC_002483.1 # RefSeq YP_001294732 NC_009602.1 # SIMILARITY Belongs to the IagB/IpgF/P19 family. {ECO 0000305}. # SUPFAM SSF53955 SSF53955 BLAST swissprot:X19F_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:X19F_ECOLI DOI 10.1007/BF00261174 http://dx.doi.org/10.1007/BF00261174 EMBL AF106329 http://www.ebi.ac.uk/ena/data/view/AF106329 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL X00545 http://www.ebi.ac.uk/ena/data/view/X00545 EMBL X17539 http://www.ebi.ac.uk/ena/data/view/X17539 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1263507 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263507 GeneID 5290951 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5290951 InterPro IPR008258 http://www.ebi.ac.uk/interpro/entry/IPR008258 InterPro IPR023346 http://www.ebi.ac.uk/interpro/entry/IPR023346 OMA INEICHA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=INEICHA PSORT swissprot:X19F_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:X19F_ECOLI PSORT-B swissprot:X19F_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:X19F_ECOLI PSORT2 swissprot:X19F_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:X19F_ECOLI Pfam PF01464 http://pfam.xfam.org/family/PF01464 Phobius swissprot:X19F_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:X19F_ECOLI PhylomeDB P47737 http://phylomedb.org/?seqid=P47737 ProteinModelPortal P47737 http://www.proteinmodelportal.org/query/uniprot/P47737 PubMed 2693941 http://www.ncbi.nlm.nih.gov/pubmed/2693941 PubMed 6329741 http://www.ncbi.nlm.nih.gov/pubmed/6329741 RefSeq NP_061449 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061449 RefSeq WP_000759160 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000759160 RefSeq YP_001294732 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001294732 SMR P47737 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P47737 SUPFAM SSF53955 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53955 UniProtKB X19F_ECOLI http://www.uniprot.org/uniprot/X19F_ECOLI UniProtKB-AC P47737 http://www.uniprot.org/uniprot/P47737 charge swissprot:X19F_ECOLI http://rest.g-language.org/emboss/charge/swissprot:X19F_ECOLI epestfind swissprot:X19F_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:X19F_ECOLI garnier swissprot:X19F_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:X19F_ECOLI helixturnhelix swissprot:X19F_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:X19F_ECOLI hmoment swissprot:X19F_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:X19F_ECOLI iep swissprot:X19F_ECOLI http://rest.g-language.org/emboss/iep/swissprot:X19F_ECOLI inforesidue swissprot:X19F_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:X19F_ECOLI octanol swissprot:X19F_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:X19F_ECOLI pepcoil swissprot:X19F_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:X19F_ECOLI pepdigest swissprot:X19F_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:X19F_ECOLI pepinfo swissprot:X19F_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:X19F_ECOLI pepnet swissprot:X19F_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:X19F_ECOLI pepstats swissprot:X19F_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:X19F_ECOLI pepwheel swissprot:X19F_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:X19F_ECOLI pepwindow swissprot:X19F_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:X19F_ECOLI sigcleave swissprot:X19F_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:X19F_ECOLI ## Database ID URL or Descriptions # BioGrid 4260263 8 # EcoGene EG13954 ydhT # INDUCTION Up-regulated by the oxygen-responsive transcription factor FNR under anaerobic conditions. Repressed in the presence of nitrate or nitrite via the two-component systems NarXL and NarPQ, respectively. {ECO:0000269|PubMed 18227264}. # IntAct P77147 3 # Organism YDHT_ECOLI Escherichia coli (strain K12) # PATRIC 32118644 VBIEscCol129921_1740 # PIR E64924 E64924 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDHT_ECOLI Uncharacterized protein YdhT # RefSeq NP_416184 NC_000913.3 # RefSeq WP_000587525 NZ_LN832404.1 # eggNOG ENOG4108Y7C Bacteria # eggNOG ENOG4111MKC LUCA BLAST swissprot:YDHT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDHT_ECOLI BioCyc ECOL316407:JW1659-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1659-MONOMER BioCyc EcoCyc:G6897-MONOMER http://biocyc.org/getid?id=EcoCyc:G6897-MONOMER DIP DIP-11739N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11739N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1099/mic.0.2007/012146-0 http://dx.doi.org/10.1099/mic.0.2007/012146-0 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U68703 http://www.ebi.ac.uk/ena/data/view/U68703 EchoBASE EB3712 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3712 EcoGene EG13954 http://www.ecogene.org/geneInfo.php?eg_id=EG13954 EnsemblBacteria AAC74739 http://www.ensemblgenomes.org/id/AAC74739 EnsemblBacteria AAC74739 http://www.ensemblgenomes.org/id/AAC74739 EnsemblBacteria BAA15441 http://www.ensemblgenomes.org/id/BAA15441 EnsemblBacteria BAA15441 http://www.ensemblgenomes.org/id/BAA15441 EnsemblBacteria BAA15441 http://www.ensemblgenomes.org/id/BAA15441 EnsemblBacteria b1669 http://www.ensemblgenomes.org/id/b1669 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945960 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945960 HOGENOM HOG000120942 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120942&db=HOGENOM6 InParanoid P77147 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77147 IntAct P77147 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77147* KEGG_Gene ecj:JW1659 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1659 KEGG_Gene eco:b1669 http://www.genome.jp/dbget-bin/www_bget?eco:b1669 OMA TGYKGHA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TGYKGHA PSORT swissprot:YDHT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDHT_ECOLI PSORT-B swissprot:YDHT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDHT_ECOLI PSORT2 swissprot:YDHT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDHT_ECOLI Phobius swissprot:YDHT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDHT_ECOLI ProteinModelPortal P77147 http://www.proteinmodelportal.org/query/uniprot/P77147 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18227264 http://www.ncbi.nlm.nih.gov/pubmed/18227264 PubMed 9023191 http://www.ncbi.nlm.nih.gov/pubmed/9023191 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416184 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416184 RefSeq WP_000587525 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000587525 STRING 511145.b1669 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1669&targetmode=cogs UniProtKB YDHT_ECOLI http://www.uniprot.org/uniprot/YDHT_ECOLI UniProtKB-AC P77147 http://www.uniprot.org/uniprot/P77147 charge swissprot:YDHT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDHT_ECOLI eggNOG ENOG4108Y7C http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Y7C eggNOG ENOG4111MKC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111MKC epestfind swissprot:YDHT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDHT_ECOLI garnier swissprot:YDHT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDHT_ECOLI helixturnhelix swissprot:YDHT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDHT_ECOLI hmoment swissprot:YDHT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDHT_ECOLI iep swissprot:YDHT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDHT_ECOLI inforesidue swissprot:YDHT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDHT_ECOLI octanol swissprot:YDHT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDHT_ECOLI pepcoil swissprot:YDHT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDHT_ECOLI pepdigest swissprot:YDHT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDHT_ECOLI pepinfo swissprot:YDHT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDHT_ECOLI pepnet swissprot:YDHT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDHT_ECOLI pepstats swissprot:YDHT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDHT_ECOLI pepwheel swissprot:YDHT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDHT_ECOLI pepwindow swissprot:YDHT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDHT_ECOLI sigcleave swissprot:YDHT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDHT_ECOLI ## Database ID URL or Descriptions # BioGrid 4261040 9 # EcoGene EG13279 yedL # GO_component GO:0031248 protein acetyltransferase complex; IBA:GO_Central. # GO_function GO:0004596 peptide alpha-N-acetyltransferase activity; IBA:GO_Central. # GO_process GO:0017189 N-terminal peptidyl-alanine acetylation; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0006464 cellular protein modification process # Gene3D 3.40.630.30 -; 1. # IntAct P76319 2 # InterPro IPR000182 GNAT_dom # InterPro IPR016181 Acyl_CoA_acyltransferase # KEGG_Brite ko01000 Enzymes # Organism YEDL_ECOLI Escherichia coli (strain K12) # PATRIC 32119199 VBIEscCol129921_2014 # PIR A64957 A64957 # PROSITE PS51186 GNAT # Pfam PF00583 Acetyltransf_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEDL_ECOLI Uncharacterized N-acetyltransferase YedL # RefSeq NP_416442 NC_000913.3 # RefSeq WP_000494172 NZ_LN832404.1 # SIMILARITY Belongs to the acetyltransferase family. {ECO 0000305}. # SIMILARITY Contains 1 N-acetyltransferase domain. {ECO:0000255|PROSITE-ProRule PRU00532}. # SUPFAM SSF55729 SSF55729 # eggNOG COG0454 LUCA # eggNOG ENOG4108HF7 Bacteria BLAST swissprot:YEDL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEDL_ECOLI BioCyc ECOL316407:JW1917-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1917-MONOMER BioCyc EcoCyc:G7040-MONOMER http://biocyc.org/getid?id=EcoCyc:G7040-MONOMER COG COG0454 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0454 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1099/00221287-139-7-1401 http://dx.doi.org/10.1099/00221287-139-7-1401 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L13279 http://www.ebi.ac.uk/ena/data/view/L13279 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.3.1.- http://enzyme.expasy.org/EC/2.3.1.- EchoBASE EB3064 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3064 EcoGene EG13279 http://www.ecogene.org/geneInfo.php?eg_id=EG13279 EnsemblBacteria AAC74999 http://www.ensemblgenomes.org/id/AAC74999 EnsemblBacteria AAC74999 http://www.ensemblgenomes.org/id/AAC74999 EnsemblBacteria BAE76552 http://www.ensemblgenomes.org/id/BAE76552 EnsemblBacteria BAE76552 http://www.ensemblgenomes.org/id/BAE76552 EnsemblBacteria BAE76552 http://www.ensemblgenomes.org/id/BAE76552 EnsemblBacteria b1932 http://www.ensemblgenomes.org/id/b1932 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0031248 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031248 GO_function GO:0004596 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004596 GO_process GO:0017189 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017189 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 Gene3D 3.40.630.30 http://www.cathdb.info/version/latest/superfamily/3.40.630.30 GeneID 946437 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946437 HOGENOM HOG000078531 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000078531&db=HOGENOM6 InParanoid P76319 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76319 IntAct P76319 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76319* IntEnz 2.3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1 InterPro IPR000182 http://www.ebi.ac.uk/interpro/entry/IPR000182 InterPro IPR016181 http://www.ebi.ac.uk/interpro/entry/IPR016181 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1917 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1917 KEGG_Gene eco:b1932 http://www.genome.jp/dbget-bin/www_bget?eco:b1932 KEGG_Orthology KO:K03829 http://www.genome.jp/dbget-bin/www_bget?KO:K03829 OMA DMYATSP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DMYATSP PROSITE PS51186 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51186 PSORT swissprot:YEDL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEDL_ECOLI PSORT-B swissprot:YEDL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEDL_ECOLI PSORT2 swissprot:YEDL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEDL_ECOLI Pfam PF00583 http://pfam.xfam.org/family/PF00583 Phobius swissprot:YEDL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEDL_ECOLI PhylomeDB P76319 http://phylomedb.org/?seqid=P76319 ProteinModelPortal P76319 http://www.proteinmodelportal.org/query/uniprot/P76319 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8371104 http://www.ncbi.nlm.nih.gov/pubmed/8371104 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416442 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416442 RefSeq WP_000494172 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000494172 STRING 511145.b1932 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1932&targetmode=cogs STRING COG0454 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0454&targetmode=cogs SUPFAM SSF55729 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55729 UniProtKB YEDL_ECOLI http://www.uniprot.org/uniprot/YEDL_ECOLI UniProtKB-AC P76319 http://www.uniprot.org/uniprot/P76319 charge swissprot:YEDL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEDL_ECOLI eggNOG COG0454 http://eggnogapi.embl.de/nog_data/html/tree/COG0454 eggNOG ENOG4108HF7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108HF7 epestfind swissprot:YEDL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEDL_ECOLI garnier swissprot:YEDL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEDL_ECOLI helixturnhelix swissprot:YEDL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEDL_ECOLI hmoment swissprot:YEDL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEDL_ECOLI iep swissprot:YEDL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEDL_ECOLI inforesidue swissprot:YEDL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEDL_ECOLI octanol swissprot:YEDL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEDL_ECOLI pepcoil swissprot:YEDL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEDL_ECOLI pepdigest swissprot:YEDL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEDL_ECOLI pepinfo swissprot:YEDL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEDL_ECOLI pepnet swissprot:YEDL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEDL_ECOLI pepstats swissprot:YEDL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEDL_ECOLI pepwheel swissprot:YEDL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEDL_ECOLI pepwindow swissprot:YEDL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEDL_ECOLI sigcleave swissprot:YEDL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEDL_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES THIL_ECOLI Kinetic parameters KM=1.1 uM for thiamine-monophosphate {ECO 0000269|PubMed 4567662}; KM=270 uM for ATP {ECO 0000269|PubMed 4567662}; pH dependence Optimum pH is about 8.0. {ECO 0000269|PubMed 4567662}; # CATALYTIC ACTIVITY ATP + thiamine phosphate = ADP + thiamine diphosphate. {ECO:0000269|PubMed 4567662}. # CDD cd02194 ThiL # ENZYME REGULATION Is markedly activated by the monovalent cations K(+), NH(4)(+), and Rb(+). Is significantly inhibited by ADP, AMP, p-chloromercuribenzoate, N-ethylmaleimide, pyrophosphate, and EDTA. {ECO:0000269|PubMed 4567662}. # EcoGene EG20227 thiL # FUNCTION THIL_ECOLI Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1. Cannot use thiamine as substrate. Is highly specific for ATP as phosphate donor. {ECO 0000269|PubMed 4567662, ECO 0000269|PubMed 6284709}. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IDA:EcoCyc. # GO_function GO:0009030 thiamine-phosphate kinase activity; IDA:UniProtKB. # GO_function GO:0046872 metal ion binding; IDA:EcoCyc. # GO_process GO:0009228 thiamine biosynthetic process; IDA:EcoCyc. # GO_process GO:0009229 thiamine diphosphate biosynthetic process; IDA:UniProtKB. # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.30.1330.10 -; 1. # Gene3D 3.90.650.10 -; 1. # HAMAP MF_02128 TMP_kinase # IntAct P0AGG0 15 # InterPro IPR006283 ThiL # InterPro IPR010918 AIR_synth_C_dom # InterPro IPR016188 PurM-like_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00730 Thiamine metabolism # MISCELLANEOUS Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate. {ECO 0000250}. # Organism THIL_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30270 PTHR30270 # PATHWAY Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate step 1/1. # PATRIC 32115983 VBIEscCol129921_0433 # PIR A64771 A64771 # PIRSF PIRSF005303 Thiam_monoph_kin # Pfam PF00586 AIRS # Pfam PF02769 AIRS_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName THIL_ECOLI Thiamine-monophosphate kinase # RefSeq NP_414951 NC_000913.3 # RefSeq WP_000742109 NZ_LN832404.1 # SIMILARITY Belongs to the thiamine-monophosphate kinase family. {ECO 0000305}. # SUPFAM SSF56042 SSF56042 # TIGRFAMs TIGR01379 thiL # UniPathway UPA00060 UER00142 # eggNOG COG0611 LUCA # eggNOG ENOG4105CG2 Bacteria BLAST swissprot:THIL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:THIL_ECOLI BioCyc ECOL316407:JW0407-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0407-MONOMER BioCyc EcoCyc:THI-P-KIN-MONOMER http://biocyc.org/getid?id=EcoCyc:THI-P-KIN-MONOMER BioCyc MetaCyc:THI-P-KIN-MONOMER http://biocyc.org/getid?id=MetaCyc:THI-P-KIN-MONOMER COG COG0611 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0611 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.4.16 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.4.16 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D17333 http://www.ebi.ac.uk/ena/data/view/D17333 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 ENZYME 2.7.4.16 http://enzyme.expasy.org/EC/2.7.4.16 EchoBASE EB4149 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4149 EcoGene EG20227 http://www.ecogene.org/geneInfo.php?eg_id=EG20227 EnsemblBacteria AAC73520 http://www.ensemblgenomes.org/id/AAC73520 EnsemblBacteria AAC73520 http://www.ensemblgenomes.org/id/AAC73520 EnsemblBacteria BAE76197 http://www.ensemblgenomes.org/id/BAE76197 EnsemblBacteria BAE76197 http://www.ensemblgenomes.org/id/BAE76197 EnsemblBacteria BAE76197 http://www.ensemblgenomes.org/id/BAE76197 EnsemblBacteria b0417 http://www.ensemblgenomes.org/id/b0417 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0009030 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009030 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0009228 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009228 GO_process GO:0009229 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009229 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.30.1330.10 http://www.cathdb.info/version/latest/superfamily/3.30.1330.10 Gene3D 3.90.650.10 http://www.cathdb.info/version/latest/superfamily/3.90.650.10 GeneID 947387 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947387 HAMAP MF_02128 http://hamap.expasy.org/unirule/MF_02128 HOGENOM HOG000228429 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000228429&db=HOGENOM6 InParanoid P0AGG0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGG0 IntAct P0AGG0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AGG0* IntEnz 2.7.4.16 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.4.16 InterPro IPR006283 http://www.ebi.ac.uk/interpro/entry/IPR006283 InterPro IPR010918 http://www.ebi.ac.uk/interpro/entry/IPR010918 InterPro IPR016188 http://www.ebi.ac.uk/interpro/entry/IPR016188 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0407 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0407 KEGG_Gene eco:b0417 http://www.genome.jp/dbget-bin/www_bget?eco:b0417 KEGG_Orthology KO:K00946 http://www.genome.jp/dbget-bin/www_bget?KO:K00946 KEGG_Pathway ko00730 http://www.genome.jp/kegg-bin/show_pathway?ko00730 KEGG_Reaction rn:R00617 http://www.genome.jp/dbget-bin/www_bget?rn:R00617 OMA DIYAMNA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DIYAMNA PANTHER PTHR30270 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30270 PSORT swissprot:THIL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:THIL_ECOLI PSORT-B swissprot:THIL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:THIL_ECOLI PSORT2 swissprot:THIL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:THIL_ECOLI Pfam PF00586 http://pfam.xfam.org/family/PF00586 Pfam PF02769 http://pfam.xfam.org/family/PF02769 Phobius swissprot:THIL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:THIL_ECOLI PhylomeDB P0AGG0 http://phylomedb.org/?seqid=P0AGG0 ProteinModelPortal P0AGG0 http://www.proteinmodelportal.org/query/uniprot/P0AGG0 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 4567662 http://www.ncbi.nlm.nih.gov/pubmed/4567662 PubMed 6284709 http://www.ncbi.nlm.nih.gov/pubmed/6284709 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414951 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414951 RefSeq WP_000742109 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000742109 SMR P0AGG0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AGG0 STRING 511145.b0417 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0417&targetmode=cogs STRING COG0611 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0611&targetmode=cogs SUPFAM SSF56042 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56042 TIGRFAMs TIGR01379 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01379 UniProtKB THIL_ECOLI http://www.uniprot.org/uniprot/THIL_ECOLI UniProtKB-AC P0AGG0 http://www.uniprot.org/uniprot/P0AGG0 charge swissprot:THIL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:THIL_ECOLI eggNOG COG0611 http://eggnogapi.embl.de/nog_data/html/tree/COG0611 eggNOG ENOG4105CG2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CG2 epestfind swissprot:THIL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:THIL_ECOLI garnier swissprot:THIL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:THIL_ECOLI helixturnhelix swissprot:THIL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:THIL_ECOLI hmoment swissprot:THIL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:THIL_ECOLI iep swissprot:THIL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:THIL_ECOLI inforesidue swissprot:THIL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:THIL_ECOLI octanol swissprot:THIL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:THIL_ECOLI pepcoil swissprot:THIL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:THIL_ECOLI pepdigest swissprot:THIL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:THIL_ECOLI pepinfo swissprot:THIL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:THIL_ECOLI pepnet swissprot:THIL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:THIL_ECOLI pepstats swissprot:THIL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:THIL_ECOLI pepwheel swissprot:THIL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:THIL_ECOLI pepwindow swissprot:THIL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:THIL_ECOLI sigcleave swissprot:THIL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:THIL_ECOLI ## Database ID URL or Descriptions # EcoGene EG14485 ypdK # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # INDUCTION YPDK_ECOLI In exponential phase, strongly repressed by thiol oxidant diamide (at protein level). {ECO 0000269|PubMed 19121005, ECO 0000269|PubMed 19734316}. # Organism YPDK_ECOLI Escherichia coli (strain K12) # PATRIC 32120135 VBIEscCol129921_2476 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YPDK_ECOLI Uncharacterized membrane protein YpdK # RefSeq YP_002791250 NC_000913.3 # SUBCELLULAR LOCATION YPDK_ECOLI Cell inner membrane {ECO 0000305|PubMed 19121005, ECO 0000305|PubMed 21778229}; Single-pass membrane protein {ECO 0000269|PubMed 19121005, ECO 0000269|PubMed 21778229}. BLAST swissprot:YPDK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YPDK_ECOLI BioCyc EcoCyc:MONOMER0-2874 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2874 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M111.245696 http://dx.doi.org/10.1074/jbc.M111.245696 DOI 10.1111/j.1365-2958.2008.06495.x http://dx.doi.org/10.1111/j.1365-2958.2008.06495.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00872-09 http://dx.doi.org/10.1128/JB.00872-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14485 http://www.ecogene.org/geneInfo.php?eg_id=EG14485 EnsemblBacteria ACO60002 http://www.ensemblgenomes.org/id/ACO60002 EnsemblBacteria ACO60002 http://www.ensemblgenomes.org/id/ACO60002 EnsemblBacteria b4680 http://www.ensemblgenomes.org/id/b4680 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 7751622 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7751622 KEGG_Gene eco:b4680 http://www.genome.jp/dbget-bin/www_bget?eco:b4680 PSORT swissprot:YPDK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YPDK_ECOLI PSORT-B swissprot:YPDK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YPDK_ECOLI PSORT2 swissprot:YPDK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YPDK_ECOLI Phobius swissprot:YPDK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YPDK_ECOLI PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19121005 http://www.ncbi.nlm.nih.gov/pubmed/19121005 PubMed 19734316 http://www.ncbi.nlm.nih.gov/pubmed/19734316 PubMed 21778229 http://www.ncbi.nlm.nih.gov/pubmed/21778229 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq YP_002791250 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_002791250 STRING 511145.b4680 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4680&targetmode=cogs UniProtKB YPDK_ECOLI http://www.uniprot.org/uniprot/YPDK_ECOLI UniProtKB-AC C1P610 http://www.uniprot.org/uniprot/C1P610 charge swissprot:YPDK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YPDK_ECOLI epestfind swissprot:YPDK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YPDK_ECOLI garnier swissprot:YPDK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YPDK_ECOLI helixturnhelix swissprot:YPDK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YPDK_ECOLI hmoment swissprot:YPDK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YPDK_ECOLI iep swissprot:YPDK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YPDK_ECOLI inforesidue swissprot:YPDK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YPDK_ECOLI octanol swissprot:YPDK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YPDK_ECOLI pepcoil swissprot:YPDK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YPDK_ECOLI pepdigest swissprot:YPDK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YPDK_ECOLI pepinfo swissprot:YPDK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YPDK_ECOLI pepnet swissprot:YPDK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YPDK_ECOLI pepstats swissprot:YPDK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YPDK_ECOLI pepwheel swissprot:YPDK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YPDK_ECOLI pepwindow swissprot:YPDK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YPDK_ECOLI sigcleave swissprot:YPDK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YPDK_ECOLI ## Database ID URL or Descriptions # BioGrid 4263168 8 # DISRUPTION PHENOTYPE Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain. {ECO:0000269|PubMed 20345943}. # EcoGene EG14125 yfcV # FUNCTION YFCV_ECOLI Part of the yfcOPQRSUV fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes. {ECO 0000269|PubMed 20345943}. # GO_component GO:0009289 pilus; IEA:InterPro. # GO_process GO:0007155 cell adhesion; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0007155 cell adhesion # Gene3D 2.60.40.1090 -; 1. # INDUCTION Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression. {ECO:0000269|PubMed 20345943}. # InterPro IPR000259 Adhesion_dom_fimbrial # InterPro IPR008966 Adhesion_dom # MISCELLANEOUS The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed. {ECO:0000305|PubMed 20345943}. # Organism YFCV_ECOLI Escherichia coli (strain K12) # PATRIC 32120051 VBIEscCol129921_2435 # PIR A65007 A65007 # Pfam PF00419 Fimbrial # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFCV_ECOLI Uncharacterized fimbrial-like protein YfcV # RefSeq NP_416841 NC_000913.3 # RefSeq WP_000033316 NZ_LN832404.1 # SIMILARITY Belongs to the fimbrial protein family. {ECO 0000305}. # SUPFAM SSF49401 SSF49401 BLAST swissprot:YFCV_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFCV_ECOLI BioCyc ECOL316407:JW2336-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2336-MONOMER BioCyc EcoCyc:G7210-MONOMER http://biocyc.org/getid?id=EcoCyc:G7210-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1462-2920.2010.02202.x http://dx.doi.org/10.1111/j.1462-2920.2010.02202.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3877 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3877 EcoGene EG14125 http://www.ecogene.org/geneInfo.php?eg_id=EG14125 EnsemblBacteria AAC75399 http://www.ensemblgenomes.org/id/AAC75399 EnsemblBacteria AAC75399 http://www.ensemblgenomes.org/id/AAC75399 EnsemblBacteria BAA16193 http://www.ensemblgenomes.org/id/BAA16193 EnsemblBacteria BAA16193 http://www.ensemblgenomes.org/id/BAA16193 EnsemblBacteria BAA16193 http://www.ensemblgenomes.org/id/BAA16193 EnsemblBacteria b2339 http://www.ensemblgenomes.org/id/b2339 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009289 GO_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 Gene3D 2.60.40.1090 http://www.cathdb.info/version/latest/superfamily/2.60.40.1090 GeneID 949109 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949109 HOGENOM HOG000260127 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260127&db=HOGENOM6 IntAct P77288 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77288* InterPro IPR000259 http://www.ebi.ac.uk/interpro/entry/IPR000259 InterPro IPR008966 http://www.ebi.ac.uk/interpro/entry/IPR008966 KEGG_Gene ecj:JW2336 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2336 KEGG_Gene eco:b2339 http://www.genome.jp/dbget-bin/www_bget?eco:b2339 OMA GPANADN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GPANADN PSORT swissprot:YFCV_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFCV_ECOLI PSORT-B swissprot:YFCV_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFCV_ECOLI PSORT2 swissprot:YFCV_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFCV_ECOLI Pfam PF00419 http://pfam.xfam.org/family/PF00419 Phobius swissprot:YFCV_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFCV_ECOLI ProteinModelPortal P77288 http://www.proteinmodelportal.org/query/uniprot/P77288 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20345943 http://www.ncbi.nlm.nih.gov/pubmed/20345943 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416841 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416841 RefSeq WP_000033316 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000033316 SMR P77288 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77288 STRING 511145.b2339 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2339&targetmode=cogs SUPFAM SSF49401 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49401 UniProtKB YFCV_ECOLI http://www.uniprot.org/uniprot/YFCV_ECOLI UniProtKB-AC P77288 http://www.uniprot.org/uniprot/P77288 charge swissprot:YFCV_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFCV_ECOLI epestfind swissprot:YFCV_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFCV_ECOLI garnier swissprot:YFCV_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFCV_ECOLI helixturnhelix swissprot:YFCV_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFCV_ECOLI hmoment swissprot:YFCV_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFCV_ECOLI iep swissprot:YFCV_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFCV_ECOLI inforesidue swissprot:YFCV_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFCV_ECOLI octanol swissprot:YFCV_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFCV_ECOLI pepcoil swissprot:YFCV_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFCV_ECOLI pepdigest swissprot:YFCV_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFCV_ECOLI pepinfo swissprot:YFCV_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFCV_ECOLI pepnet swissprot:YFCV_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFCV_ECOLI pepstats swissprot:YFCV_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFCV_ECOLI pepwheel swissprot:YFCV_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFCV_ECOLI pepwindow swissprot:YFCV_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFCV_ECOLI sigcleave swissprot:YFCV_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFCV_ECOLI ## Database ID URL or Descriptions # BioGrid 4259129 6 # CDD cd04458 CSP_CDS # EcoGene EG12203 cspB # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003697 single-stranded DNA binding; IDA:EcoliWiki. # GO_function GO:0003723 RNA binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0009409 response to cold; IDA:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0003723 RNA binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # INDUCTION CSPB_ECOLI In response to low temperature. # IntAct P36995 33 # InterPro IPR002059 CSP_DNA-bd # InterPro IPR011129 Cold_shock_prot # InterPro IPR012156 Cold_shock_CspA # InterPro IPR012340 NA-bd_OB-fold # InterPro IPR019844 Cold-shock_CS # KEGG_Brite ko03000 Transcription factors # Organism CSPB_ECOLI Escherichia coli (strain K12) # PATRIC 32118416 VBIEscCol129921_1628 # PIR S43617 S43617 # PIRSF PIRSF002599 Cold_shock_A # PRINTS PR00050 COLDSHOCK # PROSITE PS00352 COLD_SHOCK # Pfam PF00313 CSD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CSPB_ECOLI Cold shock-like protein CspB # RefSeq NP_416075 NC_000913.3 # RefSeq WP_000066484 NZ_LN832404.1 # SIMILARITY Contains 1 CSD (cold-shock) domain. {ECO 0000305}. # SMART SM00357 CSP # SUBCELLULAR LOCATION CSPB_ECOLI Cytoplasm {ECO 0000250}. # SUPFAM SSF50249 SSF50249 # eggNOG COG1278 LUCA # eggNOG ENOG4105VEQ Bacteria BLAST swissprot:CSPB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CSPB_ECOLI BioCyc ECOL316407:JW1549-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1549-MONOMER BioCyc EcoCyc:EG12203-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12203-MONOMER COG COG1278 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1278 DIP DIP-9334N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9334N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/sj.jim.2900463 http://dx.doi.org/10.1038/sj.jim.2900463 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1111/j.1365-2958.1994.tb00361.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb00361.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AF003590 http://www.ebi.ac.uk/ena/data/view/AF003590 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L28429 http://www.ebi.ac.uk/ena/data/view/L28429 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2119 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2119 EcoGene EG12203 http://www.ecogene.org/geneInfo.php?eg_id=EG12203 EnsemblBacteria AAC74630 http://www.ensemblgenomes.org/id/AAC74630 EnsemblBacteria AAC74630 http://www.ensemblgenomes.org/id/AAC74630 EnsemblBacteria BAA15256 http://www.ensemblgenomes.org/id/BAA15256 EnsemblBacteria BAA15256 http://www.ensemblgenomes.org/id/BAA15256 EnsemblBacteria BAA15256 http://www.ensemblgenomes.org/id/BAA15256 EnsemblBacteria b1557 http://www.ensemblgenomes.org/id/b1557 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003697 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003697 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0009409 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009409 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 946091 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946091 HOGENOM HOG000070674 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000070674&db=HOGENOM6 InParanoid P36995 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P36995 IntAct P36995 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P36995* InterPro IPR002059 http://www.ebi.ac.uk/interpro/entry/IPR002059 InterPro IPR011129 http://www.ebi.ac.uk/interpro/entry/IPR011129 InterPro IPR012156 http://www.ebi.ac.uk/interpro/entry/IPR012156 InterPro IPR012340 http://www.ebi.ac.uk/interpro/entry/IPR012340 InterPro IPR019844 http://www.ebi.ac.uk/interpro/entry/IPR019844 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW1549 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1549 KEGG_Gene eco:b1557 http://www.genome.jp/dbget-bin/www_bget?eco:b1557 KEGG_Orthology KO:K03704 http://www.genome.jp/dbget-bin/www_bget?KO:K03704 MINT MINT-1241665 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1241665 OMA YSAISME http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YSAISME PRINTS PR00050 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00050 PROSITE PS00352 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00352 PSORT swissprot:CSPB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CSPB_ECOLI PSORT-B swissprot:CSPB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CSPB_ECOLI PSORT2 swissprot:CSPB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CSPB_ECOLI Pfam PF00313 http://pfam.xfam.org/family/PF00313 Phobius swissprot:CSPB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CSPB_ECOLI PhylomeDB P36995 http://phylomedb.org/?seqid=P36995 ProteinModelPortal P36995 http://www.proteinmodelportal.org/query/uniprot/P36995 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8022261 http://www.ncbi.nlm.nih.gov/pubmed/8022261 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9439003 http://www.ncbi.nlm.nih.gov/pubmed/9439003 RefSeq NP_416075 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416075 RefSeq WP_000066484 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000066484 SMART SM00357 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00357 SMR P36995 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P36995 STRING 511145.b1557 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1557&targetmode=cogs STRING COG1278 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1278&targetmode=cogs SUPFAM SSF50249 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50249 UniProtKB CSPB_ECOLI http://www.uniprot.org/uniprot/CSPB_ECOLI UniProtKB-AC P36995 http://www.uniprot.org/uniprot/P36995 charge swissprot:CSPB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CSPB_ECOLI eggNOG COG1278 http://eggnogapi.embl.de/nog_data/html/tree/COG1278 eggNOG ENOG4105VEQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VEQ epestfind swissprot:CSPB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CSPB_ECOLI garnier swissprot:CSPB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CSPB_ECOLI helixturnhelix swissprot:CSPB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CSPB_ECOLI hmoment swissprot:CSPB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CSPB_ECOLI iep swissprot:CSPB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CSPB_ECOLI inforesidue swissprot:CSPB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CSPB_ECOLI octanol swissprot:CSPB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CSPB_ECOLI pepcoil swissprot:CSPB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CSPB_ECOLI pepdigest swissprot:CSPB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CSPB_ECOLI pepinfo swissprot:CSPB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CSPB_ECOLI pepnet swissprot:CSPB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CSPB_ECOLI pepstats swissprot:CSPB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CSPB_ECOLI pepwheel swissprot:CSPB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CSPB_ECOLI pepwindow swissprot:CSPB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CSPB_ECOLI sigcleave swissprot:CSPB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CSPB_ECOLI ## Database ID URL or Descriptions # BioGrid 4261978 352 # EcoGene EG13790 ddpA # FUNCTION DDPA_ECOLI Part of the ABC transporter complex DdpABCDF, which is probably involved in D,D-dipeptide transport. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IBA:GO_Central. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IEA:InterPro. # GO_function GO:0015197 peptide transporter activity; IBA:GO_Central. # GO_process GO:0015031 protein transport; IEA:UniProtKB-KW. # GO_process GO:0042938 dipeptide transport; IBA:GO_Central. # GO_process GO:0055085 transmembrane transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # INDUCTION Induced by RpoS in stationary phase. {ECO:0000269|PubMed 9751644}. # IntAct P76128 2 # InterPro IPR000914 SBP_5_dom # InterPro IPR023765 SBP_5_CS # InterPro IPR030678 Peptide/Ni-bd # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00239 Peptides/nickel transport system # KEGG_Brite ko02000 Transporters # Organism DDPA_ECOLI Escherichia coli (strain K12) # PATRIC 32118268 VBIEscCol129921_1554 # PIR B64902 B64902 # PIRSF PIRSF002741 MppA # PROSITE PS01040 SBP_BACTERIAL_5 # Pfam PF00496 SBP_bac_5 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DDPA_ECOLI Probable D,D-dipeptide-binding periplasmic protein DdpA # RefSeq NP_416004 NC_000913.3 # RefSeq WP_000830550 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial solute-binding protein 5 family. {ECO 0000305}. # SUBCELLULAR LOCATION DDPA_ECOLI Periplasm {ECO 0000305}. # SUBUNIT The complex is composed of two ATP-binding proteins (DdpD and DdpF), two transmembrane proteins (DdpB and DdpC) and a solute-binding protein (DdpA). {ECO 0000305}. # TCDB 3.A.1.5.38 the atp-binding cassette (abc) superfamily # eggNOG COG0747 LUCA # eggNOG ENOG4105DEF Bacteria BLAST swissprot:DDPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DDPA_ECOLI BioCyc ECOL316407:JW5240-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5240-MONOMER BioCyc EcoCyc:YDDS-MONOMER http://biocyc.org/getid?id=EcoCyc:YDDS-MONOMER COG COG0747 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0747 DIP DIP-11672N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11672N DOI 10.1016/S1074-5521(98)90005-9 http://dx.doi.org/10.1016/S1074-5521(98)90005-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.96.20.11028 http://dx.doi.org/10.1073/pnas.96.20.11028 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3551 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3551 EcoGene EG13790 http://www.ecogene.org/geneInfo.php?eg_id=EG13790 EnsemblBacteria AAC74560 http://www.ensemblgenomes.org/id/AAC74560 EnsemblBacteria AAC74560 http://www.ensemblgenomes.org/id/AAC74560 EnsemblBacteria BAA15142 http://www.ensemblgenomes.org/id/BAA15142 EnsemblBacteria BAA15142 http://www.ensemblgenomes.org/id/BAA15142 EnsemblBacteria BAA15142 http://www.ensemblgenomes.org/id/BAA15142 EnsemblBacteria b1487 http://www.ensemblgenomes.org/id/b1487 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0015197 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015197 GO_process GO:0015031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031 GO_process GO:0042938 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042938 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 946052 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946052 HOGENOM HOG000200399 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000200399&db=HOGENOM6 InParanoid P76128 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76128 IntAct P76128 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76128* InterPro IPR000914 http://www.ebi.ac.uk/interpro/entry/IPR000914 InterPro IPR023765 http://www.ebi.ac.uk/interpro/entry/IPR023765 InterPro IPR030678 http://www.ebi.ac.uk/interpro/entry/IPR030678 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5240 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5240 KEGG_Gene eco:b1487 http://www.genome.jp/dbget-bin/www_bget?eco:b1487 KEGG_Orthology KO:K02035 http://www.genome.jp/dbget-bin/www_bget?KO:K02035 OMA FVNLGYE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FVNLGYE PROSITE PS01040 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01040 PSORT swissprot:DDPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DDPA_ECOLI PSORT-B swissprot:DDPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DDPA_ECOLI PSORT2 swissprot:DDPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DDPA_ECOLI Pfam PF00496 http://pfam.xfam.org/family/PF00496 Phobius swissprot:DDPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DDPA_ECOLI PhylomeDB P76128 http://phylomedb.org/?seqid=P76128 ProteinModelPortal P76128 http://www.proteinmodelportal.org/query/uniprot/P76128 PubMed 10500118 http://www.ncbi.nlm.nih.gov/pubmed/10500118 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9751644 http://www.ncbi.nlm.nih.gov/pubmed/9751644 RefSeq NP_416004 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416004 RefSeq WP_000830550 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000830550 SMR P76128 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76128 STRING 511145.b1487 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1487&targetmode=cogs STRING COG0747 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0747&targetmode=cogs TCDB 3.A.1.5.38 http://www.tcdb.org/search/result.php?tc=3.A.1.5.38 UniProtKB DDPA_ECOLI http://www.uniprot.org/uniprot/DDPA_ECOLI UniProtKB-AC P76128 http://www.uniprot.org/uniprot/P76128 charge swissprot:DDPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DDPA_ECOLI eggNOG COG0747 http://eggnogapi.embl.de/nog_data/html/tree/COG0747 eggNOG ENOG4105DEF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DEF epestfind swissprot:DDPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DDPA_ECOLI garnier swissprot:DDPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DDPA_ECOLI helixturnhelix swissprot:DDPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DDPA_ECOLI hmoment swissprot:DDPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DDPA_ECOLI iep swissprot:DDPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DDPA_ECOLI inforesidue swissprot:DDPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DDPA_ECOLI octanol swissprot:DDPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DDPA_ECOLI pepcoil swissprot:DDPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DDPA_ECOLI pepdigest swissprot:DDPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DDPA_ECOLI pepinfo swissprot:DDPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DDPA_ECOLI pepnet swissprot:DDPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DDPA_ECOLI pepstats swissprot:DDPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DDPA_ECOLI pepwheel swissprot:DDPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DDPA_ECOLI pepwindow swissprot:DDPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DDPA_ECOLI sigcleave swissprot:DDPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DDPA_ECOLI ## Database ID URL or Descriptions # AltName ILVG_ECOLI ALS-II # AltName ILVG_ECOLI Acetohydroxy-acid synthase II large subunit # CATALYTIC ACTIVITY ILVG_ECOLI 2 pyruvate = 2-acetolactate + CO(2). # COFACTOR ILVG_ECOLI Name=FAD; Xref=ChEBI CHEBI 57692; Evidence={ECO 0000269|PubMed 9581571}; Note=Binds 1 FAD per subunit. The role of this cofactor is not clear considering that the reaction does not involve redox chemistry. However, after removal of the FAD no AHAS activity can be detected (PubMed 9581571), indicating that the cofactor is essential. The large subunit alone does not bind FAD, and FAD is not necessary for association of the subunits. {ECO 0000269|PubMed 9581571}; # COFACTOR ILVG_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 9581571}; Note=Binds 1 Mg(2+) ion per subunit. Is not necessary for subunit association. {ECO 0000269|PubMed 9581571}; # COFACTOR ILVG_ECOLI Name=thiamine diphosphate; Xref=ChEBI CHEBI 58937; Evidence={ECO 0000269|PubMed 9581571}; Note=Binds 1 thiamine pyrophosphate per subunit. Is not necessary for subunit association. {ECO 0000269|PubMed 9581571}; # EcoGene EG10498 ilvG # FUNCTION ILVG_ECOLI Catalyzes the first step in the biosynthesis of branched-chain amino acids. # GO_function GO:0000287 magnesium ion binding; IEA:InterPro. # GO_function GO:0003984 acetolactate synthase activity; IEA:UniProtKB-EC. # GO_function GO:0030976 thiamine pyrophosphate binding; IEA:InterPro. # GO_function GO:0050660 flavin adenine dinucleotide binding; IEA:InterPro. # GO_process GO:0009097 isoleucine biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0009099 valine biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.1220 -; 1. # Gene3D 3.40.50.970 -; 2. # IntAct P00892 2 # InterPro IPR000399 TPP-bd_CS # InterPro IPR011766 TPP_enzyme-bd_C # InterPro IPR012000 Thiamin_PyroP_enz_cen_dom # InterPro IPR012001 Thiamin_PyroP_enz_TPP-bd_dom # InterPro IPR012846 Acetolactate_synth_lsu # InterPro IPR029035 DHS-like_NAD/FAD-binding_dom # InterPro IPR029061 THDP-binding # MISCELLANEOUS E.coli contains genes for 3 AHAS isozymes: ilvBN, ilvGM and ilvIH. In strain K12 only the Val-inhibitable ilvBN and ilvIH are expressed; ilvGM has a defect that disturbs the ilvG reading frame. IlvG (this protein) is Val-resistant and is expressed in K12 strains having what used to be referred to as ilv0 mutations. The ilv02096 mutation (shown here, an insertion of 2 bp, PubMed 7015336) causes a frameshift which restores the open reading frame, permitting the expression of this isozyme. # Organism ILVG_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-isoleucine biosynthesis; L- isoleucine from 2-oxobutanoate step 1/4. # PATHWAY Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate step 1/4. # PIR A26570 YCEC # PROSITE PS00187 TPP_ENZYMES # Pfam PF00205 TPP_enzyme_M # Pfam PF02775 TPP_enzyme_C # Pfam PF02776 TPP_enzyme_N # Proteomes UP000000625 Chromosome # RecName ILVG_ECOLI Acetolactate synthase isozyme 2 large subunit # SIMILARITY Belongs to the TPP enzyme family. {ECO 0000305}. # SUBUNIT Tetramer of two large (IlvG) and two small (IlvM) chains. {ECO:0000269|PubMed 9581571}. # SUPFAM SSF52467 SSF52467 # SUPFAM SSF52518 SSF52518; 2 # TIGRFAMs TIGR00118 acolac_lg # UniPathway UPA00047 UER00055 # UniPathway UPA00049 UER00059 BLAST swissprot:ILVG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ILVG_ECOLI BioCyc EcoCyc:G8221-MONOMER http://biocyc.org/getid?id=EcoCyc:G8221-MONOMER BioCyc EcoCyc:LARGEILVG-MONOMER http://biocyc.org/getid?id=EcoCyc:LARGEILVG-MONOMER BioCyc MetaCyc:G8221-MONOMER http://biocyc.org/getid?id=MetaCyc:G8221-MONOMER BioCyc MetaCyc:LARGEILVG-MONOMER http://biocyc.org/getid?id=MetaCyc:LARGEILVG-MONOMER DIP DIP-10023N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10023N DOI 10.1016/0378-1119(91)90005-V http://dx.doi.org/10.1016/0378-1119(91)90005-V DOI 10.1042/bj3270891 http://dx.doi.org/10.1042/bj3270891 DOI 10.1073/pnas.77.4.1862 http://dx.doi.org/10.1073/pnas.77.4.1862 DOI 10.1073/pnas.78.2.922 http://dx.doi.org/10.1073/pnas.78.2.922 DOI 10.1093/nar/15.5.2137 http://dx.doi.org/10.1093/nar/15.5.2137 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.2.1.6 http://www.genome.jp/dbget-bin/www_bget?EC:2.2.1.6 EMBL M10313 http://www.ebi.ac.uk/ena/data/view/M10313 EMBL M32253 http://www.ebi.ac.uk/ena/data/view/M32253 EMBL M37337 http://www.ebi.ac.uk/ena/data/view/M37337 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00289 http://www.ebi.ac.uk/ena/data/view/V00289 EMBL V00290 http://www.ebi.ac.uk/ena/data/view/V00290 EMBL X02413 http://www.ebi.ac.uk/ena/data/view/X02413 EMBL X04890 http://www.ebi.ac.uk/ena/data/view/X04890 ENZYME 2.2.1.6 http://enzyme.expasy.org/EC/2.2.1.6 EchoBASE EB0493 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0493 EcoGene EG10498 http://www.ecogene.org/geneInfo.php?eg_id=EG10498 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0003984 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003984 GO_function GO:0030976 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030976 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_process GO:0009097 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009097 GO_process GO:0009099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009099 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.1220 http://www.cathdb.info/version/latest/superfamily/3.40.50.1220 Gene3D 3.40.50.970 http://www.cathdb.info/version/latest/superfamily/3.40.50.970 HOGENOM HOG000258448 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000258448&db=HOGENOM6 InParanoid P00892 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00892 IntAct P00892 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00892* IntEnz 2.2.1.6 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.2.1.6 InterPro IPR000399 http://www.ebi.ac.uk/interpro/entry/IPR000399 InterPro IPR011766 http://www.ebi.ac.uk/interpro/entry/IPR011766 InterPro IPR012000 http://www.ebi.ac.uk/interpro/entry/IPR012000 InterPro IPR012001 http://www.ebi.ac.uk/interpro/entry/IPR012001 InterPro IPR012846 http://www.ebi.ac.uk/interpro/entry/IPR012846 InterPro IPR029035 http://www.ebi.ac.uk/interpro/entry/IPR029035 InterPro IPR029061 http://www.ebi.ac.uk/interpro/entry/IPR029061 OMA HSWVVRD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HSWVVRD PROSITE PS00187 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00187 PSORT swissprot:ILVG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ILVG_ECOLI PSORT-B swissprot:ILVG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ILVG_ECOLI PSORT2 swissprot:ILVG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ILVG_ECOLI Pfam PF00205 http://pfam.xfam.org/family/PF00205 Pfam PF02775 http://pfam.xfam.org/family/PF02775 Pfam PF02776 http://pfam.xfam.org/family/PF02776 Phobius swissprot:ILVG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ILVG_ECOLI PhylomeDB P00892 http://phylomedb.org/?seqid=P00892 ProteinModelPortal P00892 http://www.proteinmodelportal.org/query/uniprot/P00892 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 1995430 http://www.ncbi.nlm.nih.gov/pubmed/1995430 PubMed 3550695 http://www.ncbi.nlm.nih.gov/pubmed/3550695 PubMed 3897211 http://www.ncbi.nlm.nih.gov/pubmed/3897211 PubMed 6154938 http://www.ncbi.nlm.nih.gov/pubmed/6154938 PubMed 7015336 http://www.ncbi.nlm.nih.gov/pubmed/7015336 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9581571 http://www.ncbi.nlm.nih.gov/pubmed/9581571 SMR P00892 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00892 SUPFAM SSF52467 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52467 SUPFAM SSF52518 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52518 TIGRFAMs TIGR00118 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00118 UniProtKB ILVG_ECOLI http://www.uniprot.org/uniprot/ILVG_ECOLI UniProtKB-AC P00892 http://www.uniprot.org/uniprot/P00892 charge swissprot:ILVG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ILVG_ECOLI epestfind swissprot:ILVG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ILVG_ECOLI garnier swissprot:ILVG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ILVG_ECOLI helixturnhelix swissprot:ILVG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ILVG_ECOLI hmoment swissprot:ILVG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ILVG_ECOLI iep swissprot:ILVG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ILVG_ECOLI inforesidue swissprot:ILVG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ILVG_ECOLI octanol swissprot:ILVG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ILVG_ECOLI pepcoil swissprot:ILVG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ILVG_ECOLI pepdigest swissprot:ILVG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ILVG_ECOLI pepinfo swissprot:ILVG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ILVG_ECOLI pepnet swissprot:ILVG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ILVG_ECOLI pepstats swissprot:ILVG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ILVG_ECOLI pepwheel swissprot:ILVG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ILVG_ECOLI pepwindow swissprot:ILVG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ILVG_ECOLI sigcleave swissprot:ILVG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ILVG_ECOLI ## Database ID URL or Descriptions # BioGrid 4262405 14 # EcoGene EG12731 alx # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # INDUCTION ALX_ECOLI By extreme alkaline conditions. {ECO 0000269|PubMed 12107143, ECO 0000269|PubMed 2108134}. # InterPro IPR005496 Integral_membrane_TerC # InterPro IPR022369 Integral_membrane_TerC_rswitch # Organism ALX_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30238:SF0 PTHR30238:SF0 # PATRIC 32121594 VBIEscCol129921_3183 # PIR E65097 E65097 # Pfam PF03741 TerC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ALX_ECOLI Inner membrane protein alx # RefSeq WP_001098806 NZ_LN832404.1 # RefSeq YP_026201 NC_000913.3 # SIMILARITY Belongs to the TerC family. {ECO 0000305}. # SUBCELLULAR LOCATION ALX_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.109.1 the tellurium ion resistance (terc) family # TIGRFAMs TIGR03718 R_switched_Alx # eggNOG COG0861 LUCA # eggNOG ENOG4105DU1 Bacteria BLAST swissprot:ALX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ALX_ECOLI BioCyc ECOL316407:JW5515-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5515-MONOMER BioCyc EcoCyc:G7607-MONOMER http://biocyc.org/getid?id=EcoCyc:G7607-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.15.4246-4258.2002 http://dx.doi.org/10.1128/JB.184.15.4246-4258.2002 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2589 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2589 EcoGene EG12731 http://www.ecogene.org/geneInfo.php?eg_id=EG12731 EnsemblBacteria AAT48166 http://www.ensemblgenomes.org/id/AAT48166 EnsemblBacteria AAT48166 http://www.ensemblgenomes.org/id/AAT48166 EnsemblBacteria BAE77138 http://www.ensemblgenomes.org/id/BAE77138 EnsemblBacteria BAE77138 http://www.ensemblgenomes.org/id/BAE77138 EnsemblBacteria BAE77138 http://www.ensemblgenomes.org/id/BAE77138 EnsemblBacteria b3088 http://www.ensemblgenomes.org/id/b3088 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 947607 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947607 HOGENOM HOG000230189 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230189&db=HOGENOM6 InParanoid P42601 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P42601 InterPro IPR005496 http://www.ebi.ac.uk/interpro/entry/IPR005496 InterPro IPR022369 http://www.ebi.ac.uk/interpro/entry/IPR022369 KEGG_Gene ecj:JW5515 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5515 KEGG_Gene eco:b3088 http://www.genome.jp/dbget-bin/www_bget?eco:b3088 OMA HLRMTDS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HLRMTDS PANTHER PTHR30238:SF0 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30238:SF0 PSORT swissprot:ALX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ALX_ECOLI PSORT-B swissprot:ALX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ALX_ECOLI PSORT2 swissprot:ALX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ALX_ECOLI Pfam PF03741 http://pfam.xfam.org/family/PF03741 Phobius swissprot:ALX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ALX_ECOLI PhylomeDB P42601 http://phylomedb.org/?seqid=P42601 ProteinModelPortal P42601 http://www.proteinmodelportal.org/query/uniprot/P42601 PubMed 12107143 http://www.ncbi.nlm.nih.gov/pubmed/12107143 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2108134 http://www.ncbi.nlm.nih.gov/pubmed/2108134 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001098806 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001098806 RefSeq YP_026201 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026201 STRING 511145.b3088 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3088&targetmode=cogs TCDB 2.A.109.1 http://www.tcdb.org/search/result.php?tc=2.A.109.1 TIGRFAMs TIGR03718 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03718 UniProtKB ALX_ECOLI http://www.uniprot.org/uniprot/ALX_ECOLI UniProtKB-AC P42601 http://www.uniprot.org/uniprot/P42601 charge swissprot:ALX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ALX_ECOLI eggNOG COG0861 http://eggnogapi.embl.de/nog_data/html/tree/COG0861 eggNOG ENOG4105DU1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DU1 epestfind swissprot:ALX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ALX_ECOLI garnier swissprot:ALX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ALX_ECOLI helixturnhelix swissprot:ALX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ALX_ECOLI hmoment swissprot:ALX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ALX_ECOLI iep swissprot:ALX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ALX_ECOLI inforesidue swissprot:ALX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ALX_ECOLI octanol swissprot:ALX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ALX_ECOLI pepcoil swissprot:ALX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ALX_ECOLI pepdigest swissprot:ALX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ALX_ECOLI pepinfo swissprot:ALX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ALX_ECOLI pepnet swissprot:ALX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ALX_ECOLI pepstats swissprot:ALX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ALX_ECOLI pepwheel swissprot:ALX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ALX_ECOLI pepwindow swissprot:ALX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ALX_ECOLI sigcleave swissprot:ALX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ALX_ECOLI ## Database ID URL or Descriptions # AltName GroEL protein {ECO:0000255|HAMAP-Rule MF_00600} # AltName Protein Cpn60 {ECO:0000255|HAMAP-Rule MF_00600} # BRENDA 3.6.4 2026 # BioGrid 4263077 558 # CAUTION Was originally designated as the ams protein. {ECO:0000305|PubMed 2578448}. # EcoGene EG10599 groL # FUNCTION CH60_ECOLI Essential for the growth of the bacteria and the assembly of several bacteriophages. Also plays a role in coupling between replication of the F plasmid and cell division of the cell. # FUNCTION CH60_ECOLI Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_component GO:1990220 GroEL-GroES complex; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IDA:EcoCyc. # GO_function GO:0016887 ATPase activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IPI:IntAct. # GO_function GO:0051082 unfolded protein binding; IDA:EcoCyc. # GO_process GO:0006457 protein folding; IMP:EcoCyc. # GO_process GO:0007049 cell cycle; IEA:UniProtKB-KW. # GO_process GO:0009408 response to heat; IEP:EcoliWiki. # GO_process GO:0019068 virion assembly; IMP:EcoliWiki. # GO_process GO:0042026 protein refolding; IEA:UniProtKB-HAMAP. # GO_process GO:0051085 chaperone mediated protein folding requiring cofactor; IDA:EcoCyc. # GO_process GO:0051301 cell division; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_function GO:0051082 unfolded protein binding # GOslim_process GO:0006457 protein folding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0007049 cell cycle # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0044403 symbiosis, encompassing mutualism through parasitism # GOslim_process GO:0051301 cell division # Gene3D 1.10.560.10 -; 2. # Gene3D 3.50.7.10 -; 1. # HAMAP MF_00600 CH60 # INTERACTION CH60_ECOLI Self; NbExp=7; IntAct=EBI-543750, EBI-543750; P0AFG8 aceE; NbExp=2; IntAct=EBI-543750, EBI-542683; P60010 ACT1 (xeno); NbExp=5; IntAct=EBI-543750, EBI-2169; P00887 aroH; NbExp=3; IntAct=EBI-543750, EBI-1125143; P76213 cho; NbExp=2; IntAct=EBI-543750, EBI-545155; P77279 fetA; NbExp=2; IntAct=EBI-543750, EBI-560090; P19323 fhlA; NbExp=2; IntAct=EBI-543750, EBI-1113147; P0A6F9 groS; NbExp=25; IntAct=EBI-543750, EBI-369169; P77329 hyfG; NbExp=3; IntAct=EBI-543750, EBI-548413; P0AEX9 malE; NbExp=3; IntAct=EBI-543750, EBI-369910; P0A817 metK; NbExp=2; IntAct=EBI-543750, EBI-546295; P63386 mlaF; NbExp=3; IntAct=EBI-543750, EBI-561408; P0A7H0 recF; NbExp=3; IntAct=EBI-543750, EBI-556839; P37745 rfbC; NbExp=2; IntAct=EBI-543750, EBI-557071; P0AGB3 rpoH; NbExp=2; IntAct=EBI-543750, EBI-555342; P00586 TST (xeno); NbExp=2; IntAct=EBI-543750, EBI-7900146; P0A9W0 ulaR; NbExp=3; IntAct=EBI-543750, EBI-560926; P39177 uspG; NbExp=4; IntAct=EBI-543750, EBI-561722; P45527 yhbU; NbExp=3; IntAct=EBI-543750, EBI-561157; P37640 yhjB; NbExp=3; IntAct=EBI-543750, EBI-542016; P76524 ypdF; NbExp=2; IntAct=EBI-543750, EBI-1128711; # IntAct P0A6F5 698 # InterPro IPR001844 Chaprnin_Cpn60 # InterPro IPR002423 Cpn60/TCP-1 # InterPro IPR018370 Chaperonin_Cpn60_CS # InterPro IPR027409 GroEL-like_apical_dom # InterPro IPR027413 GROEL-like_equatorial # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko03110 Chaperones and folding catalysts # KEGG_Pathway ko03018 RNA degradation # KEGG_Pathway ko04940 Type I diabetes mellitus # KEGG_Pathway ko05134 Legionellosis # KEGG_Pathway ko05152 Tuberculosis # MISCELLANEOUS CH60_ECOLI This protein shows ATPase activity. # Organism CH60_ECOLI Escherichia coli (strain K12) # PATRIC 32123855 VBIEscCol129921_4275 # PDB 1AON X-ray; 3.00 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N=2-548 # PDB 1DK7 X-ray; 2.02 A; A/B=191-336 # PDB 1DKD X-ray; 2.10 A; A/B/C/D=191-336 # PDB 1FY9 X-ray; 2.20 A; A=191-376 # PDB 1FYA X-ray; 2.20 A; A=191-376 # PDB 1GR5 EM; 7.90 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N=2-548 # PDB 1GRL X-ray; 2.80 A; A/B/C/D/E/F/G=1-548 # PDB 1GRU EM; 12.50 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N=2-548 # PDB 1JON X-ray; 2.50 A; A=191-345 # PDB 1KID X-ray; 1.70 A; A=188-376 # PDB 1KP8 X-ray; 2.00 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N=2-548 # PDB 1LA1 X-ray; 2.06 A; A=188-379 # PDB 1MNF X-ray; 3.00 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N=2-548 # PDB 1OEL X-ray; 2.80 A; A/B/C/D/E/F/G=2-548 # PDB 1PCQ X-ray; 2.81 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N=2-525 # PDB 1PF9 X-ray; 2.99 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N=2-525 # PDB 1SS8 X-ray; 2.70 A; A/B/C/D/E/F/G=2-525 # PDB 1SVT X-ray; 2.81 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N=2-525 # PDB 1SX3 X-ray; 2.00 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N=2-526 # PDB 1SX4 X-ray; 3.00 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N=2-525 # PDB 1XCK X-ray; 2.92 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N=2-548 # PDB 2C7C EM; 7.70 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N=2-548 # PDB 2C7D EM; 8.70 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N=2-548 # PDB 2C7E EM; 9.70 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N=2-548 # PDB 2CGT EM; 8.20 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N=2-548 # PDB 2EU1 X-ray; 3.29 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N=1-548 # PDB 2NWC X-ray; 3.02 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N=2-548 # PDB 2YEY X-ray; 3.30 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N=2-525 # PDB 3C9V EM; 4.70 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N=2-527 # PDB 3CAU EM; 4.20 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N=2-527 # PDB 3VZ6 X-ray; 1.50 A; A=191-376 # PDB 3VZ7 X-ray; 1.80 A; A=191-376 # PDB 3VZ8 X-ray; 1.90 A; A/B/C=191-376 # PDB 3WVL X-ray; 3.79 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N=1-548 # PDB 3ZPZ EM; 8.90 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N=2-527 # PDB 3ZQ0 EM; 9.20 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N=2-525 # PDB 3ZQ1 EM; 15.90 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N=2-527 # PDB 4AAQ EM; 8.00 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N=1-548 # PDB 4AAR EM; 8.00 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N=1-548 # PDB 4AAS EM; 8.50 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N=1-548 # PDB 4AAU EM; 8.50 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N=1-548 # PDB 4AB2 EM; 8.50 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N=1-548 # PDB 4AB3 EM; 8.50 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N=1-548 # PDB 4V43 X-ray; 3.52 A; 1/2/A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X/Y/Z=2-548 # PDB 4WGL X-ray; 3.13 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N=1-548 # PDB 4WSC X-ray; 3.04 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N=1-548 # PIR S56371 BVECGL # PRINTS PR00298 CHAPERONIN60 # PROSITE PS00296 CHAPERONINS_CPN60 # PTM CH60_ECOLI Phosphorylated reversibly during heat shock. {ECO 0000269|PubMed 1349729}. # Pfam PF00118 Cpn60_TCP1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 60 kDa chaperonin {ECO:0000255|HAMAP-Rule MF_00600} # RefSeq NP_418567 NC_000913.3 # RefSeq WP_000729117 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA23934.1; Type=Frameshift; Positions=424, 455; Evidence={ECO 0000305}; # SIMILARITY Belongs to the chaperonin (HSP60) family. {ECO:0000255|HAMAP-Rule MF_00600}. # SUBCELLULAR LOCATION CH60_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00600, ECO 0000269|PubMed 20094032, ECO 0000269|PubMed 22380631}. Note=Uniformly located in the cytoplasm (PubMed 20094032). Exclusively localized in foci, usually near 1 cell pole in mid-to- late exponential phase (PubMed 22380631); polar localization depends on the minCDE operon. Foci form near midcell (Probable). {ECO 0000269|PubMed 20094032, ECO 0000269|PubMed 22380631, ECO 0000305}. # SUBUNIT Oligomer of 14 subunits composed of two stacked rings of 7 subunits. Complex can be destablized when Ala-2 and Glu-76 are mutated to match these residues in M.tuberculosis (PubMed:15327959). {ECO 0000269|PubMed:15327959}. # SUPFAM SSF52029 SSF52029 # TIGRFAMs TIGR02348 GroEL # eggNOG COG0459 LUCA # eggNOG ENOG4105CJ9 Bacteria BLAST swissprot:CH60_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CH60_ECOLI BioCyc ECOL316407:JW4103-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4103-MONOMER BioCyc EcoCyc:EG10599-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10599-MONOMER BioCyc MetaCyc:EG10599-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10599-MONOMER COG COG0459 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0459 DIP DIP-339N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-339N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1016/0014-5793(93)81600-5 http://dx.doi.org/10.1016/0014-5793(93)81600-5 DOI 10.1016/0022-2836(88)90141-6 http://dx.doi.org/10.1016/0022-2836(88)90141-6 DOI 10.1016/S0092-8674(00)81673-6 http://dx.doi.org/10.1016/S0092-8674(00)81673-6 DOI 10.1016/j.jmb.2004.07.066 http://dx.doi.org/10.1016/j.jmb.2004.07.066 DOI 10.1038/333330a0 http://dx.doi.org/10.1038/333330a0 DOI 10.1038/357167a0 http://dx.doi.org/10.1038/357167a0 DOI 10.1038/371578a0 http://dx.doi.org/10.1038/371578a0 DOI 10.1038/371614a0 http://dx.doi.org/10.1038/371614a0 DOI 10.1038/41944 http://dx.doi.org/10.1038/41944 DOI 10.1038/emboj.2009.412 http://dx.doi.org/10.1038/emboj.2009.412 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nchembio.495 http://dx.doi.org/10.1038/nchembio.495 DOI 10.1038/nsb0296-170 http://dx.doi.org/10.1038/nsb0296-170 DOI 10.1038/nsb1295-1083 http://dx.doi.org/10.1038/nsb1295-1083 DOI 10.1073/pnas.93.26.15024 http://dx.doi.org/10.1073/pnas.93.26.15024 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1107/S1744309107020295 http://dx.doi.org/10.1107/S1744309107020295 DOI 10.1111/j.1365-2958.2012.08021.x http://dx.doi.org/10.1111/j.1365-2958.2012.08021.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1266/ggs.82.291 http://dx.doi.org/10.1266/ggs.82.291 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M11294 http://www.ebi.ac.uk/ena/data/view/M11294 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X07850 http://www.ebi.ac.uk/ena/data/view/X07850 EMBL X07899 http://www.ebi.ac.uk/ena/data/view/X07899 EchoBASE EB0594 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0594 EcoGene EG10599 http://www.ecogene.org/geneInfo.php?eg_id=EG10599 EnsemblBacteria AAC77103 http://www.ensemblgenomes.org/id/AAC77103 EnsemblBacteria AAC77103 http://www.ensemblgenomes.org/id/AAC77103 EnsemblBacteria BAE78145 http://www.ensemblgenomes.org/id/BAE78145 EnsemblBacteria BAE78145 http://www.ensemblgenomes.org/id/BAE78145 EnsemblBacteria BAE78145 http://www.ensemblgenomes.org/id/BAE78145 EnsemblBacteria b4143 http://www.ensemblgenomes.org/id/b4143 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:1990220 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990220 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0051082 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051082 GO_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GO_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GO_process GO:0019068 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019068 GO_process GO:0042026 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042026 GO_process GO:0051085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051085 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_function GO:0051082 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051082 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0044403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 Gene3D 1.10.560.10 http://www.cathdb.info/version/latest/superfamily/1.10.560.10 Gene3D 3.50.7.10 http://www.cathdb.info/version/latest/superfamily/3.50.7.10 GeneID 948665 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948665 HAMAP MF_00600 http://hamap.expasy.org/unirule/MF_00600 HOGENOM HOG000076290 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000076290&db=HOGENOM6 InParanoid P0A6F5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6F5 IntAct P0A6F5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6F5* InterPro IPR001844 http://www.ebi.ac.uk/interpro/entry/IPR001844 InterPro IPR002423 http://www.ebi.ac.uk/interpro/entry/IPR002423 InterPro IPR018370 http://www.ebi.ac.uk/interpro/entry/IPR018370 InterPro IPR027409 http://www.ebi.ac.uk/interpro/entry/IPR027409 InterPro IPR027413 http://www.ebi.ac.uk/interpro/entry/IPR027413 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW4103 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4103 KEGG_Gene eco:b4143 http://www.genome.jp/dbget-bin/www_bget?eco:b4143 KEGG_Orthology KO:K04077 http://www.genome.jp/dbget-bin/www_bget?KO:K04077 KEGG_Pathway ko03018 http://www.genome.jp/kegg-bin/show_pathway?ko03018 KEGG_Pathway ko04940 http://www.genome.jp/kegg-bin/show_pathway?ko04940 KEGG_Pathway ko05134 http://www.genome.jp/kegg-bin/show_pathway?ko05134 KEGG_Pathway ko05152 http://www.genome.jp/kegg-bin/show_pathway?ko05152 MINT MINT-5232496 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5232496 OMA MLTTDCA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MLTTDCA PDB 1AON http://www.ebi.ac.uk/pdbe-srv/view/entry/1AON PDB 1DK7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1DK7 PDB 1DKD http://www.ebi.ac.uk/pdbe-srv/view/entry/1DKD PDB 1FY9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1FY9 PDB 1FYA http://www.ebi.ac.uk/pdbe-srv/view/entry/1FYA PDB 1GR5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1GR5 PDB 1GRL http://www.ebi.ac.uk/pdbe-srv/view/entry/1GRL PDB 1GRU http://www.ebi.ac.uk/pdbe-srv/view/entry/1GRU PDB 1JON http://www.ebi.ac.uk/pdbe-srv/view/entry/1JON PDB 1KID http://www.ebi.ac.uk/pdbe-srv/view/entry/1KID PDB 1KP8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1KP8 PDB 1LA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1LA1 PDB 1MNF http://www.ebi.ac.uk/pdbe-srv/view/entry/1MNF PDB 1OEL http://www.ebi.ac.uk/pdbe-srv/view/entry/1OEL PDB 1PCQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1PCQ PDB 1PF9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1PF9 PDB 1SS8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1SS8 PDB 1SVT http://www.ebi.ac.uk/pdbe-srv/view/entry/1SVT PDB 1SX3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1SX3 PDB 1SX4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1SX4 PDB 1XCK http://www.ebi.ac.uk/pdbe-srv/view/entry/1XCK PDB 2C7C http://www.ebi.ac.uk/pdbe-srv/view/entry/2C7C PDB 2C7D http://www.ebi.ac.uk/pdbe-srv/view/entry/2C7D PDB 2C7E http://www.ebi.ac.uk/pdbe-srv/view/entry/2C7E PDB 2CGT http://www.ebi.ac.uk/pdbe-srv/view/entry/2CGT PDB 2EU1 http://www.ebi.ac.uk/pdbe-srv/view/entry/2EU1 PDB 2NWC http://www.ebi.ac.uk/pdbe-srv/view/entry/2NWC PDB 2YEY http://www.ebi.ac.uk/pdbe-srv/view/entry/2YEY PDB 3C9V http://www.ebi.ac.uk/pdbe-srv/view/entry/3C9V PDB 3CAU http://www.ebi.ac.uk/pdbe-srv/view/entry/3CAU PDB 3VZ6 http://www.ebi.ac.uk/pdbe-srv/view/entry/3VZ6 PDB 3VZ7 http://www.ebi.ac.uk/pdbe-srv/view/entry/3VZ7 PDB 3VZ8 http://www.ebi.ac.uk/pdbe-srv/view/entry/3VZ8 PDB 3WVL http://www.ebi.ac.uk/pdbe-srv/view/entry/3WVL PDB 3ZPZ http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZPZ PDB 3ZQ0 http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZQ0 PDB 3ZQ1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZQ1 PDB 4AAQ http://www.ebi.ac.uk/pdbe-srv/view/entry/4AAQ PDB 4AAR http://www.ebi.ac.uk/pdbe-srv/view/entry/4AAR PDB 4AAS http://www.ebi.ac.uk/pdbe-srv/view/entry/4AAS PDB 4AAU http://www.ebi.ac.uk/pdbe-srv/view/entry/4AAU PDB 4AB2 http://www.ebi.ac.uk/pdbe-srv/view/entry/4AB2 PDB 4AB3 http://www.ebi.ac.uk/pdbe-srv/view/entry/4AB3 PDB 4V43 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V43 PDB 4WGL http://www.ebi.ac.uk/pdbe-srv/view/entry/4WGL PDB 4WSC http://www.ebi.ac.uk/pdbe-srv/view/entry/4WSC PDBsum 1AON http://www.ebi.ac.uk/pdbsum/1AON PDBsum 1DK7 http://www.ebi.ac.uk/pdbsum/1DK7 PDBsum 1DKD http://www.ebi.ac.uk/pdbsum/1DKD PDBsum 1FY9 http://www.ebi.ac.uk/pdbsum/1FY9 PDBsum 1FYA http://www.ebi.ac.uk/pdbsum/1FYA PDBsum 1GR5 http://www.ebi.ac.uk/pdbsum/1GR5 PDBsum 1GRL http://www.ebi.ac.uk/pdbsum/1GRL PDBsum 1GRU http://www.ebi.ac.uk/pdbsum/1GRU PDBsum 1JON http://www.ebi.ac.uk/pdbsum/1JON PDBsum 1KID http://www.ebi.ac.uk/pdbsum/1KID PDBsum 1KP8 http://www.ebi.ac.uk/pdbsum/1KP8 PDBsum 1LA1 http://www.ebi.ac.uk/pdbsum/1LA1 PDBsum 1MNF http://www.ebi.ac.uk/pdbsum/1MNF PDBsum 1OEL http://www.ebi.ac.uk/pdbsum/1OEL PDBsum 1PCQ http://www.ebi.ac.uk/pdbsum/1PCQ PDBsum 1PF9 http://www.ebi.ac.uk/pdbsum/1PF9 PDBsum 1SS8 http://www.ebi.ac.uk/pdbsum/1SS8 PDBsum 1SVT http://www.ebi.ac.uk/pdbsum/1SVT PDBsum 1SX3 http://www.ebi.ac.uk/pdbsum/1SX3 PDBsum 1SX4 http://www.ebi.ac.uk/pdbsum/1SX4 PDBsum 1XCK http://www.ebi.ac.uk/pdbsum/1XCK PDBsum 2C7C http://www.ebi.ac.uk/pdbsum/2C7C PDBsum 2C7D http://www.ebi.ac.uk/pdbsum/2C7D PDBsum 2C7E http://www.ebi.ac.uk/pdbsum/2C7E PDBsum 2CGT http://www.ebi.ac.uk/pdbsum/2CGT PDBsum 2EU1 http://www.ebi.ac.uk/pdbsum/2EU1 PDBsum 2NWC http://www.ebi.ac.uk/pdbsum/2NWC PDBsum 2YEY http://www.ebi.ac.uk/pdbsum/2YEY PDBsum 3C9V http://www.ebi.ac.uk/pdbsum/3C9V PDBsum 3CAU http://www.ebi.ac.uk/pdbsum/3CAU PDBsum 3VZ6 http://www.ebi.ac.uk/pdbsum/3VZ6 PDBsum 3VZ7 http://www.ebi.ac.uk/pdbsum/3VZ7 PDBsum 3VZ8 http://www.ebi.ac.uk/pdbsum/3VZ8 PDBsum 3WVL http://www.ebi.ac.uk/pdbsum/3WVL PDBsum 3ZPZ http://www.ebi.ac.uk/pdbsum/3ZPZ PDBsum 3ZQ0 http://www.ebi.ac.uk/pdbsum/3ZQ0 PDBsum 3ZQ1 http://www.ebi.ac.uk/pdbsum/3ZQ1 PDBsum 4AAQ http://www.ebi.ac.uk/pdbsum/4AAQ PDBsum 4AAR http://www.ebi.ac.uk/pdbsum/4AAR PDBsum 4AAS http://www.ebi.ac.uk/pdbsum/4AAS PDBsum 4AAU http://www.ebi.ac.uk/pdbsum/4AAU PDBsum 4AB2 http://www.ebi.ac.uk/pdbsum/4AB2 PDBsum 4AB3 http://www.ebi.ac.uk/pdbsum/4AB3 PDBsum 4V43 http://www.ebi.ac.uk/pdbsum/4V43 PDBsum 4WGL http://www.ebi.ac.uk/pdbsum/4WGL PDBsum 4WSC http://www.ebi.ac.uk/pdbsum/4WSC PRINTS PR00298 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00298 PROSITE PS00296 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00296 PSORT swissprot:CH60_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CH60_ECOLI PSORT-B swissprot:CH60_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CH60_ECOLI PSORT2 swissprot:CH60_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CH60_ECOLI Pfam PF00118 http://pfam.xfam.org/family/PF00118 Phobius swissprot:CH60_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CH60_ECOLI PhylomeDB P0A6F5 http://phylomedb.org/?seqid=P0A6F5 ProteinModelPortal P0A6F5 http://www.proteinmodelportal.org/query/uniprot/P0A6F5 PubMed 10619429 http://www.ncbi.nlm.nih.gov/pubmed/10619429 PubMed 1349729 http://www.ncbi.nlm.nih.gov/pubmed/1349729 PubMed 15327959 http://www.ncbi.nlm.nih.gov/pubmed/15327959 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17554162 http://www.ncbi.nlm.nih.gov/pubmed/17554162 PubMed 17895580 http://www.ncbi.nlm.nih.gov/pubmed/17895580 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 20094032 http://www.ncbi.nlm.nih.gov/pubmed/20094032 PubMed 21151122 http://www.ncbi.nlm.nih.gov/pubmed/21151122 PubMed 22380631 http://www.ncbi.nlm.nih.gov/pubmed/22380631 PubMed 2578448 http://www.ncbi.nlm.nih.gov/pubmed/2578448 PubMed 2897629 http://www.ncbi.nlm.nih.gov/pubmed/2897629 PubMed 2901493 http://www.ncbi.nlm.nih.gov/pubmed/2901493 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 7903255 http://www.ncbi.nlm.nih.gov/pubmed/7903255 PubMed 7935790 http://www.ncbi.nlm.nih.gov/pubmed/7935790 PubMed 7935796 http://www.ncbi.nlm.nih.gov/pubmed/7935796 PubMed 8564544 http://www.ncbi.nlm.nih.gov/pubmed/8564544 PubMed 8846220 http://www.ncbi.nlm.nih.gov/pubmed/8846220 PubMed 8986757 http://www.ncbi.nlm.nih.gov/pubmed/8986757 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9285585 http://www.ncbi.nlm.nih.gov/pubmed/9285585 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_418567 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418567 RefSeq WP_000729117 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000729117 SMR P0A6F5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6F5 STRING 511145.b4143 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4143&targetmode=cogs STRING COG0459 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0459&targetmode=cogs SUPFAM SSF52029 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52029 SWISS-2DPAGE P0A6F5 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A6F5 TIGRFAMs TIGR02348 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02348 UniProtKB CH60_ECOLI http://www.uniprot.org/uniprot/CH60_ECOLI UniProtKB-AC P0A6F5 http://www.uniprot.org/uniprot/P0A6F5 charge swissprot:CH60_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CH60_ECOLI eggNOG COG0459 http://eggnogapi.embl.de/nog_data/html/tree/COG0459 eggNOG ENOG4105CJ9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CJ9 epestfind swissprot:CH60_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CH60_ECOLI garnier swissprot:CH60_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CH60_ECOLI helixturnhelix swissprot:CH60_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CH60_ECOLI hmoment swissprot:CH60_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CH60_ECOLI iep swissprot:CH60_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CH60_ECOLI inforesidue swissprot:CH60_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CH60_ECOLI octanol swissprot:CH60_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CH60_ECOLI pepcoil swissprot:CH60_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CH60_ECOLI pepdigest swissprot:CH60_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CH60_ECOLI pepinfo swissprot:CH60_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CH60_ECOLI pepnet swissprot:CH60_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CH60_ECOLI pepstats swissprot:CH60_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CH60_ECOLI pepwheel swissprot:CH60_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CH60_ECOLI pepwindow swissprot:CH60_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CH60_ECOLI sigcleave swissprot:CH60_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CH60_ECOLI ## Database ID URL or Descriptions # AltName CITD_ECOLI Citrate lyase gamma chain # BioGrid 4259652 9 # EcoGene EG13543 citD # FUNCTION CITD_ECOLI Covalent carrier of the coenzyme of citrate lyase. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0051192 prosthetic group binding; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # HAMAP MF_00805 CitD # INDUCTION Repressed by H-NS. Part of the citCDEFXG operon. {ECO:0000269|PubMed 19429622}. # IntAct P69330 3 # InterPro IPR006495 CitD # InterPro IPR023439 Mal_deCO2ase/Cit_lyase_ACP # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00020 Citrate cycle (TCA cycle) # KEGG_Pathway ko02020 Two-component system # Organism CITD_ECOLI Escherichia coli (strain K12) # PATRIC 32116414 VBIEscCol129921_0647 # PIR G64795 G64795 # PIRSF PIRSF002736 Citrt_lyas_gamma # Pfam PF06857 ACP # ProDom PD015389 CitD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CITD_ECOLI Citrate lyase acyl carrier protein # RefSeq NP_415150 NC_000913.3 # RefSeq WP_000700703 NZ_LN832404.1 # SIMILARITY Belongs to the CitD family. {ECO 0000305}. # SUBCELLULAR LOCATION CITD_ECOLI Cytoplasm. # SUBUNIT Oligomer with a subunit composition of (alpha,beta, gamma)6. {ECO 0000250}. # TIGRFAMs TIGR01608 citD # eggNOG COG3052 LUCA # eggNOG ENOG4105XGS Bacteria BLAST swissprot:CITD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CITD_ECOLI BioCyc ECOL316407:JW0609-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0609-MONOMER BioCyc EcoCyc:ACPSUB-MONOMER http://biocyc.org/getid?id=EcoCyc:ACPSUB-MONOMER BioCyc MetaCyc:ACPSUB-MONOMER http://biocyc.org/getid?id=MetaCyc:ACPSUB-MONOMER COG COG3052 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3052 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00108-09 http://dx.doi.org/10.1128/JB.00108-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U46667 http://www.ebi.ac.uk/ena/data/view/U46667 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB3313 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3313 EcoGene EG13543 http://www.ecogene.org/geneInfo.php?eg_id=EG13543 EnsemblBacteria AAC73718 http://www.ensemblgenomes.org/id/AAC73718 EnsemblBacteria AAC73718 http://www.ensemblgenomes.org/id/AAC73718 EnsemblBacteria BAA35253 http://www.ensemblgenomes.org/id/BAA35253 EnsemblBacteria BAA35253 http://www.ensemblgenomes.org/id/BAA35253 EnsemblBacteria BAA35253 http://www.ensemblgenomes.org/id/BAA35253 EnsemblBacteria b0617 http://www.ensemblgenomes.org/id/b0617 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0051192 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051192 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GeneID 945415 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945415 HAMAP MF_00805 http://hamap.expasy.org/unirule/MF_00805 HOGENOM HOG000040480 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000040480&db=HOGENOM6 InParanoid P69330 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P69330 IntAct P69330 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69330* InterPro IPR006495 http://www.ebi.ac.uk/interpro/entry/IPR006495 InterPro IPR023439 http://www.ebi.ac.uk/interpro/entry/IPR023439 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0609 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0609 KEGG_Gene eco:b0617 http://www.genome.jp/dbget-bin/www_bget?eco:b0617 KEGG_Orthology KO:K01646 http://www.genome.jp/dbget-bin/www_bget?KO:K01646 KEGG_Pathway ko00020 http://www.genome.jp/kegg-bin/show_pathway?ko00020 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 KEGG_Reaction rn:R00362 http://www.genome.jp/dbget-bin/www_bget?rn:R00362 OMA YNWKEID http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YNWKEID PSORT swissprot:CITD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CITD_ECOLI PSORT-B swissprot:CITD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CITD_ECOLI PSORT2 swissprot:CITD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CITD_ECOLI Pfam PF06857 http://pfam.xfam.org/family/PF06857 Phobius swissprot:CITD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CITD_ECOLI PhylomeDB P69330 http://phylomedb.org/?seqid=P69330 ProteinModelPortal P69330 http://www.proteinmodelportal.org/query/uniprot/P69330 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19429622 http://www.ncbi.nlm.nih.gov/pubmed/19429622 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415150 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415150 RefSeq WP_000700703 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000700703 STRING 511145.b0617 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0617&targetmode=cogs STRING COG3052 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3052&targetmode=cogs TIGRFAMs TIGR01608 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01608 UniProtKB CITD_ECOLI http://www.uniprot.org/uniprot/CITD_ECOLI UniProtKB-AC P69330 http://www.uniprot.org/uniprot/P69330 charge swissprot:CITD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CITD_ECOLI eggNOG COG3052 http://eggnogapi.embl.de/nog_data/html/tree/COG3052 eggNOG ENOG4105XGS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105XGS epestfind swissprot:CITD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CITD_ECOLI garnier swissprot:CITD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CITD_ECOLI helixturnhelix swissprot:CITD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CITD_ECOLI hmoment swissprot:CITD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CITD_ECOLI iep swissprot:CITD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CITD_ECOLI inforesidue swissprot:CITD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CITD_ECOLI octanol swissprot:CITD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CITD_ECOLI pepcoil swissprot:CITD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CITD_ECOLI pepdigest swissprot:CITD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CITD_ECOLI pepinfo swissprot:CITD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CITD_ECOLI pepnet swissprot:CITD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CITD_ECOLI pepstats swissprot:CITD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CITD_ECOLI pepwheel swissprot:CITD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CITD_ECOLI pepwindow swissprot:CITD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CITD_ECOLI sigcleave swissprot:CITD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CITD_ECOLI ## Database ID URL or Descriptions # AltName END1_ECOLI Endonuclease I # BioGrid 4262350 55 # CATALYTIC ACTIVITY END1_ECOLI Endonucleolytic cleavage to 5'- phosphodinucleotide and 5'-phosphooligonucleotide end-products. # ENZYME REGULATION END1_ECOLI Inhibited by RNA. # EcoGene EG11336 endA # FUNCTION END1_ECOLI Has double-strand break activity. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_function GO:0004519 endonuclease activity; IDA:EcoCyc. # GO_function GO:0004530 deoxyribonuclease I activity; IEA:UniProtKB-EC. # GO_function GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters; IDA:EcoCyc. # GO_process GO:0006308 DNA catabolic process; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0004518 nuclease activity # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # InterPro IPR007346 Endonuclease-I # KEGG_Brite ko01000 Enzymes # Organism END1_ECOLI Escherichia coli (strain K12) # PATRIC 32121300 VBIEscCol129921_3038 # PIR A38966 A38966 # Pfam PF04231 Endonuclease_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName END1_ECOLI Endonuclease-1 # RefSeq NP_417420 NC_000913.3 # RefSeq WP_000286500 NZ_LN832404.1 # SIMILARITY Belongs to the EndA/NucM nuclease family. {ECO 0000305}. # SUBCELLULAR LOCATION END1_ECOLI Periplasm {ECO 0000269|PubMed 4955462}. # eggNOG COG2356 LUCA # eggNOG ENOG4105RWS Bacteria BLAST swissprot:END1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:END1_ECOLI BioCyc ECOL316407:JW2912-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2912-MONOMER BioCyc EcoCyc:EG11336-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11336-MONOMER BioCyc MetaCyc:EG11336-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11336-MONOMER COG COG2356 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2356 DOI 10.1016/0006-291X(65)90434-1 http://dx.doi.org/10.1016/0006-291X(65)90434-1 DOI 10.1016/0378-1119(94)00835-G http://dx.doi.org/10.1016/0378-1119(94)00835-G DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.21.1 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.21.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EMBL X65169 http://www.ebi.ac.uk/ena/data/view/X65169 ENZYME 3.1.21.1 http://enzyme.expasy.org/EC/3.1.21.1 EchoBASE EB1312 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1312 EcoGene EG11336 http://www.ecogene.org/geneInfo.php?eg_id=EG11336 EnsemblBacteria AAC75982 http://www.ensemblgenomes.org/id/AAC75982 EnsemblBacteria AAC75982 http://www.ensemblgenomes.org/id/AAC75982 EnsemblBacteria BAE77008 http://www.ensemblgenomes.org/id/BAE77008 EnsemblBacteria BAE77008 http://www.ensemblgenomes.org/id/BAE77008 EnsemblBacteria BAE77008 http://www.ensemblgenomes.org/id/BAE77008 EnsemblBacteria b2945 http://www.ensemblgenomes.org/id/b2945 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0004519 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004519 GO_function GO:0004530 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004530 GO_function GO:0016888 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016888 GO_process GO:0006308 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006308 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 GeneID 949092 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949092 HOGENOM HOG000281182 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000281182&db=HOGENOM6 InParanoid P25736 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P25736 IntEnz 3.1.21.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.21.1 InterPro IPR007346 http://www.ebi.ac.uk/interpro/entry/IPR007346 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2912 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2912 KEGG_Gene eco:b2945 http://www.genome.jp/dbget-bin/www_bget?eco:b2945 KEGG_Orthology KO:K01150 http://www.genome.jp/dbget-bin/www_bget?KO:K01150 OMA ADQYGQC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ADQYGQC PSORT swissprot:END1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:END1_ECOLI PSORT-B swissprot:END1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:END1_ECOLI PSORT2 swissprot:END1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:END1_ECOLI Pfam PF04231 http://pfam.xfam.org/family/PF04231 Phobius swissprot:END1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:END1_ECOLI PhylomeDB P25736 http://phylomedb.org/?seqid=P25736 ProteinModelPortal P25736 http://www.proteinmodelportal.org/query/uniprot/P25736 PubMed 14463750 http://www.ncbi.nlm.nih.gov/pubmed/14463750 PubMed 14463751 http://www.ncbi.nlm.nih.gov/pubmed/14463751 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 4955462 http://www.ncbi.nlm.nih.gov/pubmed/4955462 PubMed 7867949 http://www.ncbi.nlm.nih.gov/pubmed/7867949 PubMed 8113204 http://www.ncbi.nlm.nih.gov/pubmed/8113204 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417420 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417420 RefSeq WP_000286500 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000286500 SMR P25736 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P25736 STRING 511145.b2945 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2945&targetmode=cogs STRING COG2356 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2356&targetmode=cogs UniProtKB END1_ECOLI http://www.uniprot.org/uniprot/END1_ECOLI UniProtKB-AC P25736 http://www.uniprot.org/uniprot/P25736 charge swissprot:END1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:END1_ECOLI eggNOG COG2356 http://eggnogapi.embl.de/nog_data/html/tree/COG2356 eggNOG ENOG4105RWS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105RWS epestfind swissprot:END1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:END1_ECOLI garnier swissprot:END1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:END1_ECOLI helixturnhelix swissprot:END1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:END1_ECOLI hmoment swissprot:END1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:END1_ECOLI iep swissprot:END1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:END1_ECOLI inforesidue swissprot:END1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:END1_ECOLI octanol swissprot:END1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:END1_ECOLI pepcoil swissprot:END1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:END1_ECOLI pepdigest swissprot:END1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:END1_ECOLI pepinfo swissprot:END1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:END1_ECOLI pepnet swissprot:END1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:END1_ECOLI pepstats swissprot:END1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:END1_ECOLI pepwheel swissprot:END1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:END1_ECOLI pepwindow swissprot:END1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:END1_ECOLI sigcleave swissprot:END1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:END1_ECOLI ## Database ID URL or Descriptions # BioGrid 4262954 7 # EcoGene EG11955 yjcS # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0018741 alkyl sulfatase activity; IDA:EcoCyc. # GO_process GO:0018909 dodecyl sulfate metabolic process; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.30.1050.10 -; 1. # Gene3D 3.60.15.10 -; 2. # InterPro IPR001279 Metallo-B-lactamas # InterPro IPR003033 SCP2_sterol-bd_dom # InterPro IPR029228 Alkyl_sulf_dimr # InterPro IPR029229 Alkyl_sulf_C # Organism YJCS_ECOLI Escherichia coli (strain K12) # PATRIC 32123721 VBIEscCol129921_4209 # PDB 4PDX X-ray; 1.75 A; A/B=30-661 # PIR B65217 B65217 # Pfam PF00753 Lactamase_B # Pfam PF14863 Alkyl_sulf_dimr # Pfam PF14864 Alkyl_sulf_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJCS_ECOLI Putative alkyl/aryl-sulfatase YjcS # RefSeq NP_418507 NC_000913.3 # RefSeq WP_001066019 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAC43177.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the metallo-beta-lactamase superfamily. {ECO 0000305}. # SMART SM00849 Lactamase_B # SUPFAM SSF55718 SSF55718 # SUPFAM SSF56281 SSF56281 # eggNOG COG2015 LUCA # eggNOG ENOG4105EUZ Bacteria BLAST swissprot:YJCS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJCS_ECOLI BioCyc ECOL316407:JW5721-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5721-MONOMER BioCyc EcoCyc:EG11955-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11955-MONOMER BioCyc MetaCyc:EG11955-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11955-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.6.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.6.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.6.- http://enzyme.expasy.org/EC/3.1.6.- EchoBASE EB1898 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1898 EcoGene EG11955 http://www.ecogene.org/geneInfo.php?eg_id=EG11955 EnsemblBacteria AAC77044 http://www.ensemblgenomes.org/id/AAC77044 EnsemblBacteria AAC77044 http://www.ensemblgenomes.org/id/AAC77044 EnsemblBacteria BAE78085 http://www.ensemblgenomes.org/id/BAE78085 EnsemblBacteria BAE78085 http://www.ensemblgenomes.org/id/BAE78085 EnsemblBacteria BAE78085 http://www.ensemblgenomes.org/id/BAE78085 EnsemblBacteria b4083 http://www.ensemblgenomes.org/id/b4083 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0018741 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018741 GO_process GO:0018909 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018909 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.30.1050.10 http://www.cathdb.info/version/latest/superfamily/3.30.1050.10 Gene3D 3.60.15.10 http://www.cathdb.info/version/latest/superfamily/3.60.15.10 GeneID 948597 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948597 HOGENOM HOG000050609 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000050609&db=HOGENOM6 InParanoid P32717 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32717 IntEnz 3.1.6 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.6 InterPro IPR001279 http://www.ebi.ac.uk/interpro/entry/IPR001279 InterPro IPR003033 http://www.ebi.ac.uk/interpro/entry/IPR003033 InterPro IPR029228 http://www.ebi.ac.uk/interpro/entry/IPR029228 InterPro IPR029229 http://www.ebi.ac.uk/interpro/entry/IPR029229 KEGG_Gene ecj:JW5721 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5721 KEGG_Gene eco:b4083 http://www.genome.jp/dbget-bin/www_bget?eco:b4083 OMA ASHSWPR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ASHSWPR PDB 4PDX http://www.ebi.ac.uk/pdbe-srv/view/entry/4PDX PDBsum 4PDX http://www.ebi.ac.uk/pdbsum/4PDX PSORT swissprot:YJCS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJCS_ECOLI PSORT-B swissprot:YJCS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJCS_ECOLI PSORT2 swissprot:YJCS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJCS_ECOLI Pfam PF00753 http://pfam.xfam.org/family/PF00753 Pfam PF14863 http://pfam.xfam.org/family/PF14863 Pfam PF14864 http://pfam.xfam.org/family/PF14864 Phobius swissprot:YJCS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJCS_ECOLI PhylomeDB P32717 http://phylomedb.org/?seqid=P32717 ProteinModelPortal P32717 http://www.proteinmodelportal.org/query/uniprot/P32717 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418507 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418507 RefSeq WP_001066019 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001066019 SMART SM00849 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00849 SMR P32717 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32717 STRING 511145.b4083 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4083&targetmode=cogs SUPFAM SSF55718 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55718 SUPFAM SSF56281 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56281 UniProtKB YJCS_ECOLI http://www.uniprot.org/uniprot/YJCS_ECOLI UniProtKB-AC P32717 http://www.uniprot.org/uniprot/P32717 charge swissprot:YJCS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJCS_ECOLI eggNOG COG2015 http://eggnogapi.embl.de/nog_data/html/tree/COG2015 eggNOG ENOG4105EUZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EUZ epestfind swissprot:YJCS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJCS_ECOLI garnier swissprot:YJCS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJCS_ECOLI helixturnhelix swissprot:YJCS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJCS_ECOLI hmoment swissprot:YJCS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJCS_ECOLI iep swissprot:YJCS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJCS_ECOLI inforesidue swissprot:YJCS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJCS_ECOLI octanol swissprot:YJCS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJCS_ECOLI pepcoil swissprot:YJCS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJCS_ECOLI pepdigest swissprot:YJCS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJCS_ECOLI pepinfo swissprot:YJCS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJCS_ECOLI pepnet swissprot:YJCS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJCS_ECOLI pepstats swissprot:YJCS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJCS_ECOLI pepwheel swissprot:YJCS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJCS_ECOLI pepwindow swissprot:YJCS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJCS_ECOLI sigcleave swissprot:YJCS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJCS_ECOLI ## Database ID URL or Descriptions # BioGrid 4260477 23 # EcoGene EG12043 yejL # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # Gene3D 1.10.3390.10 -; 1. # HAMAP MF_00816 UPF0352 # InterPro IPR009857 UPF0352 # InterPro IPR023202 YejL_dom # Organism YEJL_ECOLI Escherichia coli (strain K12) # PATRIC 32119731 VBIEscCol129921_2276 # PDB 2JRX NMR; -; A/B=1-75 # PIR B64988 B64988 # PIRSF PIRSF006188 UCP006188 # Pfam PF07208 DUF1414 # ProDom PD027794 UPF0352 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UPF0352 protein YejL {ECO:0000255|HAMAP-Rule MF_00816} # RefSeq NP_416692 NC_000913.3 # RefSeq WP_001135667 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0352 family. {ECO:0000255|HAMAP- Rule MF_00816}. # eggNOG COG3082 LUCA # eggNOG ENOG4105PAN Bacteria BLAST swissprot:YEJL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEJL_ECOLI BioCyc ECOL316407:JW2175-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2175-MONOMER BioCyc EcoCyc:EG12043-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12043-MONOMER COG COG3082 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3082 DIP DIP-48181N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48181N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00008 http://www.ebi.ac.uk/ena/data/view/U00008 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1977 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1977 EcoGene EG12043 http://www.ecogene.org/geneInfo.php?eg_id=EG12043 EnsemblBacteria AAC75248 http://www.ensemblgenomes.org/id/AAC75248 EnsemblBacteria AAC75248 http://www.ensemblgenomes.org/id/AAC75248 EnsemblBacteria BAE76652 http://www.ensemblgenomes.org/id/BAE76652 EnsemblBacteria BAE76652 http://www.ensemblgenomes.org/id/BAE76652 EnsemblBacteria BAE76652 http://www.ensemblgenomes.org/id/BAE76652 EnsemblBacteria b2187 http://www.ensemblgenomes.org/id/b2187 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 Gene3D 1.10.3390.10 http://www.cathdb.info/version/latest/superfamily/1.10.3390.10 GeneID 946694 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946694 HAMAP MF_00816 http://hamap.expasy.org/unirule/MF_00816 HOGENOM HOG000218499 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218499&db=HOGENOM6 InterPro IPR009857 http://www.ebi.ac.uk/interpro/entry/IPR009857 InterPro IPR023202 http://www.ebi.ac.uk/interpro/entry/IPR023202 KEGG_Gene ecj:JW2175 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2175 KEGG_Gene eco:b2187 http://www.genome.jp/dbget-bin/www_bget?eco:b2187 KEGG_Orthology KO:K09904 http://www.genome.jp/dbget-bin/www_bget?KO:K09904 OMA HQAPTDL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HQAPTDL PDB 2JRX http://www.ebi.ac.uk/pdbe-srv/view/entry/2JRX PDBsum 2JRX http://www.ebi.ac.uk/pdbsum/2JRX PSORT swissprot:YEJL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEJL_ECOLI PSORT-B swissprot:YEJL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEJL_ECOLI PSORT2 swissprot:YEJL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEJL_ECOLI Pfam PF07208 http://pfam.xfam.org/family/PF07208 Phobius swissprot:YEJL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEJL_ECOLI ProteinModelPortal P0AD24 http://www.proteinmodelportal.org/query/uniprot/P0AD24 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416692 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416692 RefSeq WP_001135667 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001135667 SMR P0AD24 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AD24 STRING 511145.b2187 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2187&targetmode=cogs STRING COG3082 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3082&targetmode=cogs UniProtKB YEJL_ECOLI http://www.uniprot.org/uniprot/YEJL_ECOLI UniProtKB-AC P0AD24 http://www.uniprot.org/uniprot/P0AD24 charge swissprot:YEJL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEJL_ECOLI eggNOG COG3082 http://eggnogapi.embl.de/nog_data/html/tree/COG3082 eggNOG ENOG4105PAN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105PAN epestfind swissprot:YEJL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEJL_ECOLI garnier swissprot:YEJL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEJL_ECOLI helixturnhelix swissprot:YEJL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEJL_ECOLI hmoment swissprot:YEJL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEJL_ECOLI iep swissprot:YEJL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEJL_ECOLI inforesidue swissprot:YEJL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEJL_ECOLI octanol swissprot:YEJL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEJL_ECOLI pepcoil swissprot:YEJL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEJL_ECOLI pepdigest swissprot:YEJL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEJL_ECOLI pepinfo swissprot:YEJL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEJL_ECOLI pepnet swissprot:YEJL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEJL_ECOLI pepstats swissprot:YEJL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEJL_ECOLI pepwheel swissprot:YEJL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEJL_ECOLI pepwindow swissprot:YEJL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEJL_ECOLI sigcleave swissprot:YEJL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEJL_ECOLI ## Database ID URL or Descriptions # AltName GALP_ECOLI Galactose transporter # BioGrid 4260658 13 # CDD cd06174 MFS # EcoGene EG12148 galP # FUNCTION GALP_ECOLI Uptake of galactose across the boundary membrane with the concomitant transport of protons into the cell (symport system). # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GALP_ECOLI GO 0015517 galactose proton symporter activity; IDA EcoCyc. # GO_process GO:0015757 galactose transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR003663 Sugar/inositol_transpt # InterPro IPR005828 MFS_sugar_transport-like # InterPro IPR005829 Sugar_transporter_CS # InterPro IPR020846 MFS_dom # KEGG_Brite ko02000 Transporters # Organism GALP_ECOLI Escherichia coli (strain K12) # PATRIC 32121296 VBIEscCol129921_3036 # PIR F65079 F65079 # PRINTS PR00171 SUGRTRNSPORT # PROSITE PS00216 SUGAR_TRANSPORT_1 # PROSITE PS00217 SUGAR_TRANSPORT_2 # PROSITE PS50850 MFS # Pfam PF00083 Sugar_tr # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GALP_ECOLI Galactose-proton symporter # RefSeq NP_417418 NC_000913.3 # RefSeq WP_001112301 NZ_LN832404.1 # SIMILARITY Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. {ECO 0000305}. # SUBCELLULAR LOCATION GALP_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.1 the major facilitator superfamily (mfs) # TIGRFAMs TIGR00879 SP # eggNOG ENOG4107QNK Bacteria # eggNOG ENOG410XNQK LUCA BLAST swissprot:GALP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GALP_ECOLI BioCyc ECOL316407:JW2910-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2910-MONOMER BioCyc EcoCyc:GALP-MONOMER http://biocyc.org/getid?id=EcoCyc:GALP-MONOMER BioCyc MetaCyc:GALP-MONOMER http://biocyc.org/getid?id=MetaCyc:GALP-MONOMER COG COG0477 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0477 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2068 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2068 EcoGene EG12148 http://www.ecogene.org/geneInfo.php?eg_id=EG12148 EnsemblBacteria AAC75980 http://www.ensemblgenomes.org/id/AAC75980 EnsemblBacteria AAC75980 http://www.ensemblgenomes.org/id/AAC75980 EnsemblBacteria BAE77006 http://www.ensemblgenomes.org/id/BAE77006 EnsemblBacteria BAE77006 http://www.ensemblgenomes.org/id/BAE77006 EnsemblBacteria BAE77006 http://www.ensemblgenomes.org/id/BAE77006 EnsemblBacteria b2943 http://www.ensemblgenomes.org/id/b2943 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015517 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015517 GO_process GO:0015757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015757 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 947434 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947434 HOGENOM HOG000202868 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000202868&db=HOGENOM6 InParanoid P0AEP1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEP1 InterPro IPR003663 http://www.ebi.ac.uk/interpro/entry/IPR003663 InterPro IPR005828 http://www.ebi.ac.uk/interpro/entry/IPR005828 InterPro IPR005829 http://www.ebi.ac.uk/interpro/entry/IPR005829 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2910 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2910 KEGG_Gene eco:b2943 http://www.genome.jp/dbget-bin/www_bget?eco:b2943 KEGG_Orthology KO:K08137 http://www.genome.jp/dbget-bin/www_bget?KO:K08137 OMA RKYSLMI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RKYSLMI PRINTS PR00171 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00171 PROSITE PS00216 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00216 PROSITE PS00217 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00217 PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:GALP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GALP_ECOLI PSORT-B swissprot:GALP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GALP_ECOLI PSORT2 swissprot:GALP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GALP_ECOLI Pfam PF00083 http://pfam.xfam.org/family/PF00083 Phobius swissprot:GALP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GALP_ECOLI PhylomeDB P0AEP1 http://phylomedb.org/?seqid=P0AEP1 ProteinModelPortal P0AEP1 http://www.proteinmodelportal.org/query/uniprot/P0AEP1 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417418 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417418 RefSeq WP_001112301 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001112301 STRING 511145.b2943 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2943&targetmode=cogs STRING COG0477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0477&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.1 http://www.tcdb.org/search/result.php?tc=2.A.1.1 TIGRFAMs TIGR00879 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00879 UniProtKB GALP_ECOLI http://www.uniprot.org/uniprot/GALP_ECOLI UniProtKB-AC P0AEP1 http://www.uniprot.org/uniprot/P0AEP1 charge swissprot:GALP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GALP_ECOLI eggNOG ENOG4107QNK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QNK eggNOG ENOG410XNQK http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNQK epestfind swissprot:GALP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GALP_ECOLI garnier swissprot:GALP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GALP_ECOLI helixturnhelix swissprot:GALP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GALP_ECOLI hmoment swissprot:GALP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GALP_ECOLI iep swissprot:GALP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GALP_ECOLI inforesidue swissprot:GALP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GALP_ECOLI octanol swissprot:GALP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GALP_ECOLI pepcoil swissprot:GALP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GALP_ECOLI pepdigest swissprot:GALP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GALP_ECOLI pepinfo swissprot:GALP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GALP_ECOLI pepnet swissprot:GALP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GALP_ECOLI pepstats swissprot:GALP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GALP_ECOLI pepwheel swissprot:GALP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GALP_ECOLI pepwindow swissprot:GALP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GALP_ECOLI sigcleave swissprot:GALP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GALP_ECOLI ## Database ID URL or Descriptions # BioGrid 4260357 5 # EcoGene EG14025 yebW # IntAct P76275 2 # InterPro IPR009954 DUF1482 # Organism YEBW_ECOLI Escherichia coli (strain K12) # PATRIC 32118995 VBIEscCol129921_1915 # PIR E64945 E64945 # Pfam PF07358 DUF1482 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEBW_ECOLI Uncharacterized protein YebW # RefSeq NP_416351 NC_000913.3 # RefSeq WP_000457842 NZ_LN832404.1 # eggNOG ENOG4105UVW Bacteria # eggNOG ENOG41124P6 LUCA BLAST swissprot:YEBW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEBW_ECOLI BioCyc ECOL316407:JW5303-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5303-MONOMER BioCyc EcoCyc:G7010-MONOMER http://biocyc.org/getid?id=EcoCyc:G7010-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3779 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3779 EcoGene EG14025 http://www.ecogene.org/geneInfo.php?eg_id=EG14025 EnsemblBacteria AAC74907 http://www.ensemblgenomes.org/id/AAC74907 EnsemblBacteria AAC74907 http://www.ensemblgenomes.org/id/AAC74907 EnsemblBacteria BAE76542 http://www.ensemblgenomes.org/id/BAE76542 EnsemblBacteria BAE76542 http://www.ensemblgenomes.org/id/BAE76542 EnsemblBacteria BAE76542 http://www.ensemblgenomes.org/id/BAE76542 EnsemblBacteria b1837 http://www.ensemblgenomes.org/id/b1837 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946354 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946354 HOGENOM HOG000121196 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000121196&db=HOGENOM6 IntAct P76275 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76275* InterPro IPR009954 http://www.ebi.ac.uk/interpro/entry/IPR009954 KEGG_Gene ecj:JW5303 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5303 KEGG_Gene eco:b1837 http://www.genome.jp/dbget-bin/www_bget?eco:b1837 OMA TEQQCLH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TEQQCLH PSORT swissprot:YEBW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEBW_ECOLI PSORT-B swissprot:YEBW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEBW_ECOLI PSORT2 swissprot:YEBW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEBW_ECOLI Pfam PF07358 http://pfam.xfam.org/family/PF07358 Phobius swissprot:YEBW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEBW_ECOLI ProteinModelPortal P76275 http://www.proteinmodelportal.org/query/uniprot/P76275 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416351 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416351 RefSeq WP_000457842 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000457842 STRING 511145.b1837 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1837&targetmode=cogs UniProtKB YEBW_ECOLI http://www.uniprot.org/uniprot/YEBW_ECOLI UniProtKB-AC P76275 http://www.uniprot.org/uniprot/P76275 charge swissprot:YEBW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEBW_ECOLI eggNOG ENOG4105UVW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105UVW eggNOG ENOG41124P6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41124P6 epestfind swissprot:YEBW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEBW_ECOLI garnier swissprot:YEBW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEBW_ECOLI helixturnhelix swissprot:YEBW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEBW_ECOLI hmoment swissprot:YEBW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEBW_ECOLI iep swissprot:YEBW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEBW_ECOLI inforesidue swissprot:YEBW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEBW_ECOLI octanol swissprot:YEBW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEBW_ECOLI pepcoil swissprot:YEBW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEBW_ECOLI pepdigest swissprot:YEBW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEBW_ECOLI pepinfo swissprot:YEBW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEBW_ECOLI pepnet swissprot:YEBW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEBW_ECOLI pepstats swissprot:YEBW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEBW_ECOLI pepwheel swissprot:YEBW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEBW_ECOLI pepwindow swissprot:YEBW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEBW_ECOLI sigcleave swissprot:YEBW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEBW_ECOLI ## Database ID URL or Descriptions # ALTERNATIVE PRODUCTS RIR1_ECOLI Event=Alternative initiation; Named isoforms=2; Name=Alpha; IsoId=P00452-1; Sequence=Displayed; Name=Alpha'; IsoId=P00452-2; Sequence=VSP_018871, VSP_018872; # AltName RIR1_ECOLI Protein B1 # AltName RIR1_ECOLI Ribonucleoside-diphosphate reductase 1 R1 subunit # AltName RIR1_ECOLI Ribonucleotide reductase 1 # BRENDA 1.17.4 2026 # BioGrid 4262130 181 # CATALYTIC ACTIVITY RIR1_ECOLI 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H(2)O = ribonucleoside diphosphate + thioredoxin. # ENZYME REGULATION RIR1_ECOLI Under complex allosteric control mediated by deoxynucleoside triphosphates and ATP binding to separate specificity and activation sites on the alpha subunit. The type of nucleotide bound at the specificity site determines substrate preference. It seems probable that ATP makes the enzyme reduce CDP and UDP, dGTP favors ADP reduction and dTTP favors GDP reduction. Stimulated by ATP and inhibited by dATP binding to the activity site. In vitro, its activity is increased by dithiothreitol (DTT) or thioredoxins (non-specific). Inhibited by hydroxyurea, leads to dNTP depletion, replication fork arrest and genomic instability (PubMed 20005847). {ECO 0000269|PubMed 9309223, ECO 0000269|PubMed 9395490, ECO 0000305|PubMed 20005847}. # EcoGene EG10660 nrdA # FUNCTION RIR1_ECOLI Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1 contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide. It also provides redox- active cysteines. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005971 ribonucleoside-diphosphate reductase complex; IDA:EcoliWiki. # GO_function GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IDA:EcoliWiki. # GO_process GO:0006260 DNA replication; IEA:UniProtKB-UniPathway. # GO_process GO:0009263 deoxyribonucleotide biosynthetic process; IDA:EcoliWiki. # GO_process GO:0015949 nucleobase-containing small molecule interconversion; IDA:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # INDUCTION Induced 5-fold by hydroxyurea (at protein level). {ECO:0000269|PubMed 20005847}. # IntAct P00452 9 # InterPro IPR000788 RNR_lg_C # InterPro IPR005144 ATP-cone_dom # InterPro IPR008926 RNR_R1-su_N # InterPro IPR013346 NrdE_NrdA # InterPro IPR013509 RNR_lsu_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00240 Pyrimidine metabolism # MISCELLANEOUS RIR1_ECOLI E.coli produces two separate class I enzymes. This one is the functional enzyme during growth. # MISCELLANEOUS Two distinct regulatory sites have been defined one controls substrate specificity and the other regulates the overall catalytic activity. A substrate-binding catalytic site, located on R1, is formed only in the presence of the second subunit R2. # Organism RIR1_ECOLI Escherichia coli (strain K12) # PATHWAY RIR1_ECOLI Genetic information processing; DNA replication. # PATRIC 32119827 VBIEscCol129921_2323 # PDB 1QFN NMR; -; B=737-761 # PDB 1R1R X-ray; 2.90 A; A/B/C=1-761 # PDB 1RLR X-ray; 2.50 A; A=1-761 # PDB 2R1R X-ray; 3.00 A; A/B/C=1-761 # PDB 2X0X X-ray; 2.30 A; A/B/C=1-761 # PDB 2XAK X-ray; 2.80 A; A/B/C=1-761 # PDB 2XAP X-ray; 2.10 A; A/B/C=1-761 # PDB 2XAV X-ray; 2.80 A; A/B/C=1-761 # PDB 2XAW X-ray; 3.10 A; A/B/C=1-761 # PDB 2XAX X-ray; 2.75 A; A/B/C=1-761 # PDB 2XAY X-ray; 2.65 A; A/B/C=1-761 # PDB 2XAZ X-ray; 2.60 A; A/B/C=1-761 # PDB 2XO4 X-ray; 2.50 A; A/B/C=1-761 # PDB 2XO5 X-ray; 2.70 A; A/B/C=1-761 # PDB 3R1R X-ray; 3.00 A; A/B/C=1-761 # PDB 3UUS X-ray; 5.65 A; A/B/C/D=1-761 # PDB 4ERM X-ray; 3.95 A; A/B/C/D=1-761 # PDB 4ERP X-ray; 4.45 A; A/B/C/D=1-761 # PDB 4R1R X-ray; 3.20 A; A/B/C=1-761 # PDB 5CNS X-ray; 2.98 A; A/B/C/D=1-761 # PDB 5CNT X-ray; 3.25 A; A/B/C/D=1-761 # PDB 5CNU X-ray; 3.40 A; A/B/C/D=1-761 # PDB 5CNV X-ray; 3.20 A; A/B/C/D=1-761 # PDB 5R1R X-ray; 3.10 A; A/B/C=1-761 # PDB 6R1R X-ray; 3.10 A; A/B/C=1-761 # PDB 7R1R X-ray; 3.10 A; A/B/C=1-761 # PIR H64993 RDEC1R # PRINTS PR01183 RIBORDTASEM1 # PROSITE PS00089 RIBORED_LARGE # PROSITE PS51161 ATP_CONE # PTM RIR1_ECOLI Binding of the substrate occurs primarily when the active- site cysteines are reduced. # Pfam PF00317 Ribonuc_red_lgN # Pfam PF02867 Ribonuc_red_lgC # Pfam PF03477 ATP-cone # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RIR1_ECOLI Ribonucleoside-diphosphate reductase 1 subunit alpha # RefSeq NP_416737 NC_000913.3 # RefSeq WP_001075164 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA24223.1; Type=Miscellaneous discrepancy; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ribonucleoside diphosphate reductase large chain family. {ECO 0000305}. # SIMILARITY Contains 1 ATP-cone domain. {ECO:0000255|PROSITE- ProRule PRU00492}. # SUBUNIT RIR1_ECOLI Tetramer of two alpha (R1) and two beta (R2) subunits. The B1 protein is a dimer of alpha subunits. A radical transfer pathway occurs between 'Tyr-122' of R2 and R1. {ECO 0000269|PubMed 9309223, ECO 0000269|PubMed 9395490}. # SUPFAM SSF48168 SSF48168 # TIGRFAMs TIGR02506 NrdE_NrdA # eggNOG COG0209 LUCA # eggNOG ENOG4105BZH Bacteria BLAST swissprot:RIR1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RIR1_ECOLI BioCyc ECOL316407:JW2228-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2228-MONOMER BioCyc EcoCyc:NRDA-MONOMER http://biocyc.org/getid?id=EcoCyc:NRDA-MONOMER BioCyc MetaCyc:NRDA-MONOMER http://biocyc.org/getid?id=MetaCyc:NRDA-MONOMER COG COG0209 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0209 DIP DIP-584N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-584N DOI 10.1006/jmbi.1999.3067 http://dx.doi.org/10.1006/jmbi.1999.3067 DOI 10.1016/S0969-2126(97)00259-1 http://dx.doi.org/10.1016/S0969-2126(97)00259-1 DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/370533a0 http://dx.doi.org/10.1038/370533a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.81.14.4294 http://dx.doi.org/10.1073/pnas.81.14.4294 DOI 10.1074/jbc.271.34.20655 http://dx.doi.org/10.1074/jbc.271.34.20655 DOI 10.1074/jbc.272.50.31533 http://dx.doi.org/10.1074/jbc.272.50.31533 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/nar/16.9.4174 http://dx.doi.org/10.1093/nar/16.9.4174 DOI 10.1111/j.1432-1033.1985.tb09037.x http://dx.doi.org/10.1111/j.1432-1033.1985.tb09037.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.17.4.1 http://www.genome.jp/dbget-bin/www_bget?EC:1.17.4.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K02672 http://www.ebi.ac.uk/ena/data/view/K02672 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X06999 http://www.ebi.ac.uk/ena/data/view/X06999 ENZYME 1.17.4.1 http://enzyme.expasy.org/EC/1.17.4.1 EchoBASE EB0654 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0654 EcoGene EG10660 http://www.ecogene.org/geneInfo.php?eg_id=EG10660 EnsemblBacteria AAC75294 http://www.ensemblgenomes.org/id/AAC75294 EnsemblBacteria AAC75294 http://www.ensemblgenomes.org/id/AAC75294 EnsemblBacteria BAA16053 http://www.ensemblgenomes.org/id/BAA16053 EnsemblBacteria BAA16053 http://www.ensemblgenomes.org/id/BAA16053 EnsemblBacteria BAA16053 http://www.ensemblgenomes.org/id/BAA16053 EnsemblBacteria b2234 http://www.ensemblgenomes.org/id/b2234 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005971 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005971 GO_function GO:0004748 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004748 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260 GO_process GO:0009263 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009263 GO_process GO:0015949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015949 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 946612 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946612 HOGENOM HOG000278076 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278076&db=HOGENOM6 InParanoid P00452 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00452 IntAct P00452 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00452* IntEnz 1.17.4.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.17.4.1 InterPro IPR000788 http://www.ebi.ac.uk/interpro/entry/IPR000788 InterPro IPR005144 http://www.ebi.ac.uk/interpro/entry/IPR005144 InterPro IPR008926 http://www.ebi.ac.uk/interpro/entry/IPR008926 InterPro IPR013346 http://www.ebi.ac.uk/interpro/entry/IPR013346 InterPro IPR013509 http://www.ebi.ac.uk/interpro/entry/IPR013509 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW2228 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2228 KEGG_Gene eco:b2234 http://www.genome.jp/dbget-bin/www_bget?eco:b2234 KEGG_Orthology KO:K00525 http://www.genome.jp/dbget-bin/www_bget?KO:K00525 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Reaction rn:R02017 http://www.genome.jp/dbget-bin/www_bget?rn:R02017 KEGG_Reaction rn:R02018 http://www.genome.jp/dbget-bin/www_bget?rn:R02018 KEGG_Reaction rn:R02019 http://www.genome.jp/dbget-bin/www_bget?rn:R02019 KEGG_Reaction rn:R02024 http://www.genome.jp/dbget-bin/www_bget?rn:R02024 MINT MINT-1233906 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1233906 OMA YELLWQM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YELLWQM PDB 1QFN http://www.ebi.ac.uk/pdbe-srv/view/entry/1QFN PDB 1R1R http://www.ebi.ac.uk/pdbe-srv/view/entry/1R1R PDB 1RLR http://www.ebi.ac.uk/pdbe-srv/view/entry/1RLR PDB 2R1R http://www.ebi.ac.uk/pdbe-srv/view/entry/2R1R PDB 2X0X http://www.ebi.ac.uk/pdbe-srv/view/entry/2X0X PDB 2XAK http://www.ebi.ac.uk/pdbe-srv/view/entry/2XAK PDB 2XAP http://www.ebi.ac.uk/pdbe-srv/view/entry/2XAP PDB 2XAV http://www.ebi.ac.uk/pdbe-srv/view/entry/2XAV PDB 2XAW http://www.ebi.ac.uk/pdbe-srv/view/entry/2XAW PDB 2XAX http://www.ebi.ac.uk/pdbe-srv/view/entry/2XAX PDB 2XAY http://www.ebi.ac.uk/pdbe-srv/view/entry/2XAY PDB 2XAZ http://www.ebi.ac.uk/pdbe-srv/view/entry/2XAZ PDB 2XO4 http://www.ebi.ac.uk/pdbe-srv/view/entry/2XO4 PDB 2XO5 http://www.ebi.ac.uk/pdbe-srv/view/entry/2XO5 PDB 3R1R http://www.ebi.ac.uk/pdbe-srv/view/entry/3R1R PDB 3UUS http://www.ebi.ac.uk/pdbe-srv/view/entry/3UUS PDB 4ERM http://www.ebi.ac.uk/pdbe-srv/view/entry/4ERM PDB 4ERP http://www.ebi.ac.uk/pdbe-srv/view/entry/4ERP PDB 4R1R http://www.ebi.ac.uk/pdbe-srv/view/entry/4R1R PDB 5CNS http://www.ebi.ac.uk/pdbe-srv/view/entry/5CNS PDB 5CNT http://www.ebi.ac.uk/pdbe-srv/view/entry/5CNT PDB 5CNU http://www.ebi.ac.uk/pdbe-srv/view/entry/5CNU PDB 5CNV http://www.ebi.ac.uk/pdbe-srv/view/entry/5CNV PDB 5R1R http://www.ebi.ac.uk/pdbe-srv/view/entry/5R1R PDB 6R1R http://www.ebi.ac.uk/pdbe-srv/view/entry/6R1R PDB 7R1R http://www.ebi.ac.uk/pdbe-srv/view/entry/7R1R PDBsum 1QFN http://www.ebi.ac.uk/pdbsum/1QFN PDBsum 1R1R http://www.ebi.ac.uk/pdbsum/1R1R PDBsum 1RLR http://www.ebi.ac.uk/pdbsum/1RLR PDBsum 2R1R http://www.ebi.ac.uk/pdbsum/2R1R PDBsum 2X0X http://www.ebi.ac.uk/pdbsum/2X0X PDBsum 2XAK http://www.ebi.ac.uk/pdbsum/2XAK PDBsum 2XAP http://www.ebi.ac.uk/pdbsum/2XAP PDBsum 2XAV http://www.ebi.ac.uk/pdbsum/2XAV PDBsum 2XAW http://www.ebi.ac.uk/pdbsum/2XAW PDBsum 2XAX http://www.ebi.ac.uk/pdbsum/2XAX PDBsum 2XAY http://www.ebi.ac.uk/pdbsum/2XAY PDBsum 2XAZ http://www.ebi.ac.uk/pdbsum/2XAZ PDBsum 2XO4 http://www.ebi.ac.uk/pdbsum/2XO4 PDBsum 2XO5 http://www.ebi.ac.uk/pdbsum/2XO5 PDBsum 3R1R http://www.ebi.ac.uk/pdbsum/3R1R PDBsum 3UUS http://www.ebi.ac.uk/pdbsum/3UUS PDBsum 4ERM http://www.ebi.ac.uk/pdbsum/4ERM PDBsum 4ERP http://www.ebi.ac.uk/pdbsum/4ERP PDBsum 4R1R http://www.ebi.ac.uk/pdbsum/4R1R PDBsum 5CNS http://www.ebi.ac.uk/pdbsum/5CNS PDBsum 5CNT http://www.ebi.ac.uk/pdbsum/5CNT PDBsum 5CNU http://www.ebi.ac.uk/pdbsum/5CNU PDBsum 5CNV http://www.ebi.ac.uk/pdbsum/5CNV PDBsum 5R1R http://www.ebi.ac.uk/pdbsum/5R1R PDBsum 6R1R http://www.ebi.ac.uk/pdbsum/6R1R PDBsum 7R1R http://www.ebi.ac.uk/pdbsum/7R1R PRINTS PR01183 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01183 PROSITE PS00089 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00089 PROSITE PS51161 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51161 PSORT swissprot:RIR1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RIR1_ECOLI PSORT-B swissprot:RIR1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RIR1_ECOLI PSORT2 swissprot:RIR1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RIR1_ECOLI Pfam PF00317 http://pfam.xfam.org/family/PF00317 Pfam PF02867 http://pfam.xfam.org/family/PF02867 Pfam PF03477 http://pfam.xfam.org/family/PF03477 Phobius swissprot:RIR1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RIR1_ECOLI PhylomeDB P00452 http://phylomedb.org/?seqid=P00452 ProteinModelPortal P00452 http://www.proteinmodelportal.org/query/uniprot/P00452 PubMed 10493864 http://www.ncbi.nlm.nih.gov/pubmed/10493864 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 2663852 http://www.ncbi.nlm.nih.gov/pubmed/2663852 PubMed 3287341 http://www.ncbi.nlm.nih.gov/pubmed/3287341 PubMed 3894026 http://www.ncbi.nlm.nih.gov/pubmed/3894026 PubMed 6087316 http://www.ncbi.nlm.nih.gov/pubmed/6087316 PubMed 8052308 http://www.ncbi.nlm.nih.gov/pubmed/8052308 PubMed 8702814 http://www.ncbi.nlm.nih.gov/pubmed/8702814 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9309223 http://www.ncbi.nlm.nih.gov/pubmed/9309223 PubMed 9395490 http://www.ncbi.nlm.nih.gov/pubmed/9395490 RefSeq NP_416737 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416737 RefSeq WP_001075164 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001075164 SMR P00452 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00452 STRING 511145.b2234 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2234&targetmode=cogs STRING COG0209 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0209&targetmode=cogs SUPFAM SSF48168 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48168 TIGRFAMs TIGR02506 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02506 UniProtKB RIR1_ECOLI http://www.uniprot.org/uniprot/RIR1_ECOLI UniProtKB-AC P00452 http://www.uniprot.org/uniprot/P00452 charge swissprot:RIR1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RIR1_ECOLI eggNOG COG0209 http://eggnogapi.embl.de/nog_data/html/tree/COG0209 eggNOG ENOG4105BZH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZH epestfind swissprot:RIR1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RIR1_ECOLI garnier swissprot:RIR1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RIR1_ECOLI helixturnhelix swissprot:RIR1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RIR1_ECOLI hmoment swissprot:RIR1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RIR1_ECOLI iep swissprot:RIR1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RIR1_ECOLI inforesidue swissprot:RIR1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RIR1_ECOLI octanol swissprot:RIR1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RIR1_ECOLI pepcoil swissprot:RIR1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RIR1_ECOLI pepdigest swissprot:RIR1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RIR1_ECOLI pepinfo swissprot:RIR1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RIR1_ECOLI pepnet swissprot:RIR1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RIR1_ECOLI pepstats swissprot:RIR1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RIR1_ECOLI pepwheel swissprot:RIR1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RIR1_ECOLI pepwindow swissprot:RIR1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RIR1_ECOLI sigcleave swissprot:RIR1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RIR1_ECOLI ## Database ID URL or Descriptions # BioGrid 4260801 6 # CAUTION PubMed:7841459 sequence was originally thought to originate from S.typhimurium, but seems to come from an unknown E.coli strain. {ECO 0000305}. # EcoGene EG11029 trpR # FUNCTION TRPR_ECOLI This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_function GO:0043565 sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.1270.10 -; 1. # HAMAP MF_00475 Trp_repressor # IntAct P0A881 3 # InterPro IPR000831 Trp_repress # InterPro IPR010921 Trp_repressor/repl_initiator # InterPro IPR013335 Trp_repress_bac # KEGG_Brite ko03000 Transcription factors # Organism TRPR_ECOLI Escherichia coli (strain K12) # PATRIC 32124404 VBIEscCol129921_4542 # PDB 1CO0 NMR; -; A/B=2-108 # PDB 1JHG X-ray; 1.30 A; A=8-108 # PDB 1MI7 X-ray; 2.50 A; R=2-108 # PDB 1RCS NMR; -; A/B=4-107 # PDB 1TRO X-ray; 1.90 A; A/C/E/G=1-108 # PDB 1TRR X-ray; 2.40 A; A/B/D/E/G/H/J/K=2-108 # PDB 1WRP X-ray; 2.20 A; R=2-108 # PDB 1WRS NMR; -; R/S=4-108 # PDB 1WRT NMR; -; R/S=4-108 # PDB 1ZT9 X-ray; 2.00 A; A/B/D/E=2-108 # PDB 2OZ9 X-ray; 1.65 A; R=2-108 # PDB 3SSW X-ray; 1.67 A; N/R=2-108 # PDB 3SSX X-ray; 1.58 A; N/R=2-108 # PDB 3WRP X-ray; 1.80 A; A=1-108 # PIR A03568 RPECW # PIRSF PIRSF003196 Trp_repressor # Pfam PF01371 Trp_repressor # ProDom PD012582 Trp_repress_bac # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TRPR_ECOLI Trp operon repressor # RefSeq NP_418810 NC_000913.3 # RefSeq WP_000068679 NZ_LN832404.1 # SIMILARITY Belongs to the TrpR family. {ECO 0000305}. # SUBCELLULAR LOCATION TRPR_ECOLI Cytoplasm. # SUBUNIT TRPR_ECOLI Homodimer. # SUPFAM SSF48295 SSF48295 # TIGRFAMs TIGR01321 TrpR # eggNOG COG2973 LUCA # eggNOG ENOG4105R9M Bacteria BLAST swissprot:TRPR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRPR_ECOLI BioCyc ECOL316407:JW4356-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4356-MONOMER BioCyc EcoCyc:PD00423 http://biocyc.org/getid?id=EcoCyc:PD00423 COG COG2973 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2973 DIP DIP-48204N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48204N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/jmbi.1993.1076 http://dx.doi.org/10.1006/jmbi.1993.1076 DOI 10.1006/jmbi.1994.1317 http://dx.doi.org/10.1006/jmbi.1994.1317 DOI 10.1016/0167-4781(90)90047-6 http://dx.doi.org/10.1016/0167-4781(90)90047-6 DOI 10.1021/bi00479a002 http://dx.doi.org/10.1021/bi00479a002 DOI 10.1038/327591a0 http://dx.doi.org/10.1038/327591a0 DOI 10.1038/333869a0 http://dx.doi.org/10.1038/333869a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.77.12.7117 http://dx.doi.org/10.1073/pnas.77.12.7117 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1093/nar/8.7.1551 http://dx.doi.org/10.1093/nar/8.7.1551 DOI 10.1111/j.1432-1033.1991.tb16344.x http://dx.doi.org/10.1111/j.1432-1033.1991.tb16344.x DOI 10.1111/j.1432-1033.1992.tb16616.x http://dx.doi.org/10.1111/j.1432-1033.1992.tb16616.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01715 http://www.ebi.ac.uk/ena/data/view/J01715 EMBL L13768 http://www.ebi.ac.uk/ena/data/view/L13768 EMBL M69185 http://www.ebi.ac.uk/ena/data/view/M69185 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB1022 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1022 EcoGene EG11029 http://www.ecogene.org/geneInfo.php?eg_id=EG11029 EnsemblBacteria AAC77346 http://www.ensemblgenomes.org/id/AAC77346 EnsemblBacteria AAC77346 http://www.ensemblgenomes.org/id/AAC77346 EnsemblBacteria BAE78382 http://www.ensemblgenomes.org/id/BAE78382 EnsemblBacteria BAE78382 http://www.ensemblgenomes.org/id/BAE78382 EnsemblBacteria BAE78382 http://www.ensemblgenomes.org/id/BAE78382 EnsemblBacteria b4393 http://www.ensemblgenomes.org/id/b4393 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.1270.10 http://www.cathdb.info/version/latest/superfamily/1.10.1270.10 GeneID 948917 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948917 HAMAP MF_00475 http://hamap.expasy.org/unirule/MF_00475 HOGENOM HOG000288846 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000288846&db=HOGENOM6 InParanoid P0A881 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A881 IntAct P0A881 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A881* InterPro IPR000831 http://www.ebi.ac.uk/interpro/entry/IPR000831 InterPro IPR010921 http://www.ebi.ac.uk/interpro/entry/IPR010921 InterPro IPR013335 http://www.ebi.ac.uk/interpro/entry/IPR013335 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW4356 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4356 KEGG_Gene eco:b4393 http://www.genome.jp/dbget-bin/www_bget?eco:b4393 KEGG_Orthology KO:K03720 http://www.genome.jp/dbget-bin/www_bget?KO:K03720 OMA GQMSQRE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GQMSQRE PDB 1CO0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1CO0 PDB 1JHG http://www.ebi.ac.uk/pdbe-srv/view/entry/1JHG PDB 1MI7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1MI7 PDB 1RCS http://www.ebi.ac.uk/pdbe-srv/view/entry/1RCS PDB 1TRO http://www.ebi.ac.uk/pdbe-srv/view/entry/1TRO PDB 1TRR http://www.ebi.ac.uk/pdbe-srv/view/entry/1TRR PDB 1WRP http://www.ebi.ac.uk/pdbe-srv/view/entry/1WRP PDB 1WRS http://www.ebi.ac.uk/pdbe-srv/view/entry/1WRS PDB 1WRT http://www.ebi.ac.uk/pdbe-srv/view/entry/1WRT PDB 1ZT9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZT9 PDB 2OZ9 http://www.ebi.ac.uk/pdbe-srv/view/entry/2OZ9 PDB 3SSW http://www.ebi.ac.uk/pdbe-srv/view/entry/3SSW PDB 3SSX http://www.ebi.ac.uk/pdbe-srv/view/entry/3SSX PDB 3WRP http://www.ebi.ac.uk/pdbe-srv/view/entry/3WRP PDBsum 1CO0 http://www.ebi.ac.uk/pdbsum/1CO0 PDBsum 1JHG http://www.ebi.ac.uk/pdbsum/1JHG PDBsum 1MI7 http://www.ebi.ac.uk/pdbsum/1MI7 PDBsum 1RCS http://www.ebi.ac.uk/pdbsum/1RCS PDBsum 1TRO http://www.ebi.ac.uk/pdbsum/1TRO PDBsum 1TRR http://www.ebi.ac.uk/pdbsum/1TRR PDBsum 1WRP http://www.ebi.ac.uk/pdbsum/1WRP PDBsum 1WRS http://www.ebi.ac.uk/pdbsum/1WRS PDBsum 1WRT http://www.ebi.ac.uk/pdbsum/1WRT PDBsum 1ZT9 http://www.ebi.ac.uk/pdbsum/1ZT9 PDBsum 2OZ9 http://www.ebi.ac.uk/pdbsum/2OZ9 PDBsum 3SSW http://www.ebi.ac.uk/pdbsum/3SSW PDBsum 3SSX http://www.ebi.ac.uk/pdbsum/3SSX PDBsum 3WRP http://www.ebi.ac.uk/pdbsum/3WRP PSORT swissprot:TRPR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRPR_ECOLI PSORT-B swissprot:TRPR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRPR_ECOLI PSORT2 swissprot:TRPR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRPR_ECOLI Pfam PF01371 http://pfam.xfam.org/family/PF01371 Phobius swissprot:TRPR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRPR_ECOLI ProteinModelPortal P0A881 http://www.proteinmodelportal.org/query/uniprot/P0A881 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1740124 http://www.ncbi.nlm.nih.gov/pubmed/1740124 PubMed 1935980 http://www.ncbi.nlm.nih.gov/pubmed/1935980 PubMed 1938883 http://www.ncbi.nlm.nih.gov/pubmed/1938883 PubMed 2182120 http://www.ncbi.nlm.nih.gov/pubmed/2182120 PubMed 2207078 http://www.ncbi.nlm.nih.gov/pubmed/2207078 PubMed 3290685 http://www.ncbi.nlm.nih.gov/pubmed/3290685 PubMed 3600756 http://www.ncbi.nlm.nih.gov/pubmed/3600756 PubMed 7001368 http://www.ncbi.nlm.nih.gov/pubmed/7001368 PubMed 7012834 http://www.ncbi.nlm.nih.gov/pubmed/7012834 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 7841459 http://www.ncbi.nlm.nih.gov/pubmed/7841459 PubMed 8176748 http://www.ncbi.nlm.nih.gov/pubmed/8176748 PubMed 8433368 http://www.ncbi.nlm.nih.gov/pubmed/8433368 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_418810 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418810 RefSeq WP_000068679 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000068679 SMR P0A881 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A881 STRING 511145.b4393 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4393&targetmode=cogs STRING COG2973 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2973&targetmode=cogs SUPFAM SSF48295 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48295 TIGRFAMs TIGR01321 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01321 UniProtKB TRPR_ECOLI http://www.uniprot.org/uniprot/TRPR_ECOLI UniProtKB-AC P0A881 http://www.uniprot.org/uniprot/P0A881 charge swissprot:TRPR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRPR_ECOLI eggNOG COG2973 http://eggnogapi.embl.de/nog_data/html/tree/COG2973 eggNOG ENOG4105R9M http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105R9M epestfind swissprot:TRPR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRPR_ECOLI garnier swissprot:TRPR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRPR_ECOLI helixturnhelix swissprot:TRPR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRPR_ECOLI hmoment swissprot:TRPR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRPR_ECOLI iep swissprot:TRPR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRPR_ECOLI inforesidue swissprot:TRPR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRPR_ECOLI octanol swissprot:TRPR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRPR_ECOLI pepcoil swissprot:TRPR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRPR_ECOLI pepdigest swissprot:TRPR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRPR_ECOLI pepinfo swissprot:TRPR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRPR_ECOLI pepnet swissprot:TRPR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRPR_ECOLI pepstats swissprot:TRPR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRPR_ECOLI pepwheel swissprot:TRPR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRPR_ECOLI pepwindow swissprot:TRPR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRPR_ECOLI sigcleave swissprot:TRPR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRPR_ECOLI ## Database ID URL or Descriptions # BioGrid 4261182 11 # EcoGene EG13004 yghT # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.300 -; 1. # IntAct Q46844 5 # InterPro IPR027417 P-loop_NTPase # Organism YGHT_ECOLI Escherichia coli (strain K12) # PATRIC 32121388 VBIEscCol129921_3081 # PIR H65084 H65084 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGHT_ECOLI Uncharacterized ATP-binding protein YghT # RefSeq NP_417460 NC_000913.3 # RefSeq WP_001190781 NZ_LN832404.1 # SIMILARITY To E.coli YghR and YghS. {ECO 0000305}. # SUPFAM SSF52540 SSF52540 # eggNOG ENOG4108GH0 Bacteria # eggNOG ENOG410ZT6J LUCA BLAST swissprot:YGHT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGHT_ECOLI BioCyc ECOL316407:JW2954-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2954-MONOMER BioCyc EcoCyc:G7552-MONOMER http://biocyc.org/getid?id=EcoCyc:G7552-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2826 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2826 EcoGene EG13004 http://www.ecogene.org/geneInfo.php?eg_id=EG13004 EnsemblBacteria AAC76022 http://www.ensemblgenomes.org/id/AAC76022 EnsemblBacteria AAC76022 http://www.ensemblgenomes.org/id/AAC76022 EnsemblBacteria BAE77047 http://www.ensemblgenomes.org/id/BAE77047 EnsemblBacteria BAE77047 http://www.ensemblgenomes.org/id/BAE77047 EnsemblBacteria BAE77047 http://www.ensemblgenomes.org/id/BAE77047 EnsemblBacteria b2986 http://www.ensemblgenomes.org/id/b2986 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947477 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947477 HOGENOM HOG000124979 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000124979&db=HOGENOM6 IntAct Q46844 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46844* InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Gene ecj:JW2954 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2954 KEGG_Gene eco:b2986 http://www.genome.jp/dbget-bin/www_bget?eco:b2986 OMA EQIPGAY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EQIPGAY PSORT swissprot:YGHT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGHT_ECOLI PSORT-B swissprot:YGHT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGHT_ECOLI PSORT2 swissprot:YGHT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGHT_ECOLI Phobius swissprot:YGHT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGHT_ECOLI PhylomeDB Q46844 http://phylomedb.org/?seqid=Q46844 ProteinModelPortal Q46844 http://www.proteinmodelportal.org/query/uniprot/Q46844 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417460 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417460 RefSeq WP_001190781 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001190781 SMR Q46844 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46844 STRING 511145.b2986 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2986&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB YGHT_ECOLI http://www.uniprot.org/uniprot/YGHT_ECOLI UniProtKB-AC Q46844 http://www.uniprot.org/uniprot/Q46844 charge swissprot:YGHT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGHT_ECOLI eggNOG ENOG4108GH0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108GH0 eggNOG ENOG410ZT6J http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZT6J epestfind swissprot:YGHT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGHT_ECOLI garnier swissprot:YGHT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGHT_ECOLI helixturnhelix swissprot:YGHT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGHT_ECOLI hmoment swissprot:YGHT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGHT_ECOLI iep swissprot:YGHT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGHT_ECOLI inforesidue swissprot:YGHT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGHT_ECOLI octanol swissprot:YGHT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGHT_ECOLI pepcoil swissprot:YGHT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGHT_ECOLI pepdigest swissprot:YGHT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGHT_ECOLI pepinfo swissprot:YGHT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGHT_ECOLI pepnet swissprot:YGHT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGHT_ECOLI pepstats swissprot:YGHT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGHT_ECOLI pepwheel swissprot:YGHT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGHT_ECOLI pepwindow swissprot:YGHT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGHT_ECOLI sigcleave swissprot:YGHT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGHT_ECOLI ## Database ID URL or Descriptions # EcoGene EG20260 mokB # FUNCTION MOKB_ECOLI Overlapping regulatory peptide whose translation enables hokB expression. {ECO 0000305}. # Organism MOKB_ECOLI Escherichia coli (strain K12) # PIR G64893 G64893 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MOKB_ECOLI Regulatory protein MokB # RefSeq NP_415937 NC_000913.3 BLAST swissprot:MOKB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MOKB_ECOLI BioCyc ECOL316407:JW5882-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5882-MONOMER BioCyc EcoCyc:G6736-MONOMER http://biocyc.org/getid?id=EcoCyc:G6736-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1999.01431.x http://dx.doi.org/10.1046/j.1365-2958.1999.01431.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4159 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4159 EcoGene EG20260 http://www.ecogene.org/geneInfo.php?eg_id=EG20260 EnsemblBacteria AAC74502 http://www.ensemblgenomes.org/id/AAC74502 EnsemblBacteria AAC74502 http://www.ensemblgenomes.org/id/AAC74502 EnsemblBacteria BAE76433 http://www.ensemblgenomes.org/id/BAE76433 EnsemblBacteria BAE76433 http://www.ensemblgenomes.org/id/BAE76433 EnsemblBacteria BAE76433 http://www.ensemblgenomes.org/id/BAE76433 EnsemblBacteria b1420 http://www.ensemblgenomes.org/id/b1420 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 948820 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948820 HOGENOM HOG000009728 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009728&db=HOGENOM6 KEGG_Gene ecj:JW5882 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5882 KEGG_Gene eco:b1420 http://www.genome.jp/dbget-bin/www_bget?eco:b1420 PSORT swissprot:MOKB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MOKB_ECOLI PSORT-B swissprot:MOKB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MOKB_ECOLI PSORT2 swissprot:MOKB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MOKB_ECOLI Phobius swissprot:MOKB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MOKB_ECOLI ProteinModelPortal P76096 http://www.proteinmodelportal.org/query/uniprot/P76096 PubMed 10361310 http://www.ncbi.nlm.nih.gov/pubmed/10361310 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415937 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415937 SMR P76096 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76096 STRING 511145.b1420 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1420&targetmode=cogs UniProtKB MOKB_ECOLI http://www.uniprot.org/uniprot/MOKB_ECOLI UniProtKB-AC P76096 http://www.uniprot.org/uniprot/P76096 charge swissprot:MOKB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MOKB_ECOLI epestfind swissprot:MOKB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MOKB_ECOLI garnier swissprot:MOKB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MOKB_ECOLI helixturnhelix swissprot:MOKB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MOKB_ECOLI hmoment swissprot:MOKB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MOKB_ECOLI iep swissprot:MOKB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MOKB_ECOLI inforesidue swissprot:MOKB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MOKB_ECOLI octanol swissprot:MOKB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MOKB_ECOLI pepcoil swissprot:MOKB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MOKB_ECOLI pepdigest swissprot:MOKB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MOKB_ECOLI pepinfo swissprot:MOKB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MOKB_ECOLI pepnet swissprot:MOKB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MOKB_ECOLI pepstats swissprot:MOKB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MOKB_ECOLI pepwheel swissprot:MOKB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MOKB_ECOLI pepwindow swissprot:MOKB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MOKB_ECOLI sigcleave swissprot:MOKB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MOKB_ECOLI ## Database ID URL or Descriptions # BioGrid 4261427 5 # EcoGene EG10484 hypB # FUNCTION HYPB_ECOLI Required for the maturation of the three [NiFe]hydrogenases. Exhibits a low intrinsic GTPase activity. The GTP hydrolysis catalyzed by HypB is an integral process in the incorporation of nickel into hydrogenases. {ECO 0000269|PubMed 7601092}. # GO_function GO:0003924 GTPase activity; IDA:EcoCyc. # GO_function GO:0005525 GTP binding; IEA:UniProtKB-KW. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_function GO:0016151 nickel cation binding; IDA:EcoCyc. # GO_process GO:0006461 protein complex assembly; IEA:InterPro. # GO_process GO:0051188 cofactor biosynthetic process; IMP:EcoCyc. # GO_process GO:0051604 protein maturation; IMP:EcoCyc. # GOslim_function GO:0003924 GTPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0051186 cofactor metabolic process # GOslim_process GO:0051604 protein maturation # Gene3D 3.40.50.300 -; 1. # INTERACTION HYPB_ECOLI P0A9K9 slyD; NbExp=4; IntAct=EBI-558261, EBI-369251; # IntAct P0AAN3 9 # InterPro IPR003495 CobW/HypB/UreG_dom # InterPro IPR004392 Hyd_acc_HypB # InterPro IPR027417 P-loop_NTPase # Organism HYPB_ECOLI Escherichia coli (strain K12) # PATRIC 32120854 VBIEscCol129921_2819 # PIR C65053 C65053 # Pfam PF02492 cobW # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HYPB_ECOLI Hydrogenase isoenzymes nickel incorporation protein HypB # RefSeq NP_417207 NC_000913.3 # RefSeq WP_000337665 NZ_LN832404.1 # SIMILARITY Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily. {ECO 0000305}. # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR00073 hypB # eggNOG COG0378 LUCA # eggNOG ENOG4107RSS Bacteria BLAST swissprot:HYPB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HYPB_ECOLI BioCyc ECOL316407:JW2697-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2697-MONOMER BioCyc EcoCyc:EG10484-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10484-MONOMER BioCyc MetaCyc:EG10484-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10484-MONOMER COG COG0378 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0378 DIP DIP-36428N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36428N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1991.tb01833.x http://dx.doi.org/10.1111/j.1365-2958.1991.tb01833.x DOI 10.1111/j.1432-1033.1995.tb20543.x http://dx.doi.org/10.1111/j.1432-1033.1995.tb20543.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EMBL X54543 http://www.ebi.ac.uk/ena/data/view/X54543 EchoBASE EB0479 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0479 EcoGene EG10484 http://www.ecogene.org/geneInfo.php?eg_id=EG10484 EnsemblBacteria AAC75769 http://www.ensemblgenomes.org/id/AAC75769 EnsemblBacteria AAC75769 http://www.ensemblgenomes.org/id/AAC75769 EnsemblBacteria BAE76804 http://www.ensemblgenomes.org/id/BAE76804 EnsemblBacteria BAE76804 http://www.ensemblgenomes.org/id/BAE76804 EnsemblBacteria BAE76804 http://www.ensemblgenomes.org/id/BAE76804 EnsemblBacteria b2727 http://www.ensemblgenomes.org/id/b2727 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0016151 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016151 GO_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GO_process GO:0051188 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051188 GO_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 GOslim_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GOslim_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947194 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947194 HOGENOM HOG000236980 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000236980&db=HOGENOM6 InParanoid P0AAN3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAN3 IntAct P0AAN3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAN3* InterPro IPR003495 http://www.ebi.ac.uk/interpro/entry/IPR003495 InterPro IPR004392 http://www.ebi.ac.uk/interpro/entry/IPR004392 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Gene ecj:JW2697 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2697 KEGG_Gene eco:b2727 http://www.genome.jp/dbget-bin/www_bget?eco:b2727 KEGG_Orthology KO:K04652 http://www.genome.jp/dbget-bin/www_bget?KO:K04652 MINT MINT-1293453 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1293453 OMA GTHAPGQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GTHAPGQ PSORT swissprot:HYPB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HYPB_ECOLI PSORT-B swissprot:HYPB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HYPB_ECOLI PSORT2 swissprot:HYPB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HYPB_ECOLI Pfam PF02492 http://pfam.xfam.org/family/PF02492 Phobius swissprot:HYPB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HYPB_ECOLI PhylomeDB P0AAN3 http://phylomedb.org/?seqid=P0AAN3 ProteinModelPortal P0AAN3 http://www.proteinmodelportal.org/query/uniprot/P0AAN3 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1849603 http://www.ncbi.nlm.nih.gov/pubmed/1849603 PubMed 7601092 http://www.ncbi.nlm.nih.gov/pubmed/7601092 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417207 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417207 RefSeq WP_000337665 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000337665 SMR P0AAN3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAN3 STRING 511145.b2727 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2727&targetmode=cogs STRING COG0378 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0378&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SWISS-2DPAGE P0AAN3 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AAN3 TIGRFAMs TIGR00073 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00073 UniProtKB HYPB_ECOLI http://www.uniprot.org/uniprot/HYPB_ECOLI UniProtKB-AC P0AAN3 http://www.uniprot.org/uniprot/P0AAN3 charge swissprot:HYPB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HYPB_ECOLI eggNOG COG0378 http://eggnogapi.embl.de/nog_data/html/tree/COG0378 eggNOG ENOG4107RSS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107RSS epestfind swissprot:HYPB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HYPB_ECOLI garnier swissprot:HYPB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HYPB_ECOLI helixturnhelix swissprot:HYPB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HYPB_ECOLI hmoment swissprot:HYPB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HYPB_ECOLI iep swissprot:HYPB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HYPB_ECOLI inforesidue swissprot:HYPB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HYPB_ECOLI octanol swissprot:HYPB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HYPB_ECOLI pepcoil swissprot:HYPB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HYPB_ECOLI pepdigest swissprot:HYPB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HYPB_ECOLI pepinfo swissprot:HYPB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HYPB_ECOLI pepnet swissprot:HYPB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HYPB_ECOLI pepstats swissprot:HYPB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HYPB_ECOLI pepwheel swissprot:HYPB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HYPB_ECOLI pepwindow swissprot:HYPB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HYPB_ECOLI sigcleave swissprot:HYPB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HYPB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260520 7 # EcoGene EG13185 elaB # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006950 response to stress # INDUCTION Maximally expressed between 6 and 12 hours of growth, in early stationary phase. {ECO:0000269|PubMed 22661687}. # IntAct P0AEH5 10 # InterPro IPR010279 DUF883_ElaB # Organism ELAB_ECOLI Escherichia coli (strain K12) # PATRIC 32119899 VBIEscCol129921_2359 # PIR H64997 H64997 # Pfam PF05957 DUF883 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ELAB_ECOLI Protein ElaB # RefSeq NP_416769 NC_000913.3 # RefSeq WP_000070621 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=Z50849; Type=Frameshift; Positions=73; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ElaB/YgaM/YqjD family. {ECO 0000305}. # SUBCELLULAR LOCATION ELAB_ECOLI Cell inner membrane {ECO 0000305}; Single- pass membrane protein {ECO 0000305}. # SUBUNIT ELAB_ECOLI Upon overexpression binds to ribosomes. # eggNOG COG4575 LUCA # eggNOG ENOG4105TNS Bacteria BLAST swissprot:ELAB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ELAB_ECOLI BioCyc ECOL316407:JW2261-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2261-MONOMER BioCyc EcoCyc:G7173-MONOMER http://biocyc.org/getid?id=EcoCyc:G7173-MONOMER COG COG4575 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4575 DIP DIP-47919N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47919N DOI 10.1016/0014-5793(95)01436-5 http://dx.doi.org/10.1016/0014-5793(95)01436-5 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00396-12 http://dx.doi.org/10.1128/JB.00396-12 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U58768 http://www.ebi.ac.uk/ena/data/view/U58768 EMBL Z50849 http://www.ebi.ac.uk/ena/data/view/Z50849 EchoBASE EB2977 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2977 EcoGene EG13185 http://www.ecogene.org/geneInfo.php?eg_id=EG13185 EnsemblBacteria AAC75326 http://www.ensemblgenomes.org/id/AAC75326 EnsemblBacteria AAC75326 http://www.ensemblgenomes.org/id/AAC75326 EnsemblBacteria BAA16093 http://www.ensemblgenomes.org/id/BAA16093 EnsemblBacteria BAA16093 http://www.ensemblgenomes.org/id/BAA16093 EnsemblBacteria BAA16093 http://www.ensemblgenomes.org/id/BAA16093 EnsemblBacteria b2266 http://www.ensemblgenomes.org/id/b2266 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 946751 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946751 HOGENOM HOG000256775 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000256775&db=HOGENOM6 InParanoid P0AEH5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEH5 IntAct P0AEH5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEH5* InterPro IPR010279 http://www.ebi.ac.uk/interpro/entry/IPR010279 KEGG_Gene ecj:JW2261 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2261 KEGG_Gene eco:b2266 http://www.genome.jp/dbget-bin/www_bget?eco:b2266 KEGG_Orthology KO:K05594 http://www.genome.jp/dbget-bin/www_bget?KO:K05594 MINT MINT-1311168 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1311168 OMA EYVHEKP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EYVHEKP PSORT swissprot:ELAB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ELAB_ECOLI PSORT-B swissprot:ELAB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ELAB_ECOLI PSORT2 swissprot:ELAB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ELAB_ECOLI Pfam PF05957 http://pfam.xfam.org/family/PF05957 Phobius swissprot:ELAB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ELAB_ECOLI ProteinModelPortal P0AEH5 http://www.proteinmodelportal.org/query/uniprot/P0AEH5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 22661687 http://www.ncbi.nlm.nih.gov/pubmed/22661687 PubMed 8549818 http://www.ncbi.nlm.nih.gov/pubmed/8549818 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416769 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416769 RefSeq WP_000070621 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000070621 STRING 511145.b2266 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2266&targetmode=cogs STRING COG4575 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4575&targetmode=cogs UniProtKB ELAB_ECOLI http://www.uniprot.org/uniprot/ELAB_ECOLI UniProtKB-AC P0AEH5 http://www.uniprot.org/uniprot/P0AEH5 charge swissprot:ELAB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ELAB_ECOLI eggNOG COG4575 http://eggnogapi.embl.de/nog_data/html/tree/COG4575 eggNOG ENOG4105TNS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105TNS epestfind swissprot:ELAB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ELAB_ECOLI garnier swissprot:ELAB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ELAB_ECOLI helixturnhelix swissprot:ELAB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ELAB_ECOLI hmoment swissprot:ELAB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ELAB_ECOLI iep swissprot:ELAB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ELAB_ECOLI inforesidue swissprot:ELAB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ELAB_ECOLI octanol swissprot:ELAB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ELAB_ECOLI pepcoil swissprot:ELAB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ELAB_ECOLI pepdigest swissprot:ELAB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ELAB_ECOLI pepinfo swissprot:ELAB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ELAB_ECOLI pepnet swissprot:ELAB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ELAB_ECOLI pepstats swissprot:ELAB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ELAB_ECOLI pepwheel swissprot:ELAB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ELAB_ECOLI pepwindow swissprot:ELAB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ELAB_ECOLI sigcleave swissprot:ELAB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ELAB_ECOLI ## Database ID URL or Descriptions # AltName SRLD_ECOLI Glucitol-6-phosphate dehydrogenase # AltName SRLD_ECOLI Ketosephosphate reductase # BioGrid 4260703 10 # BioGrid 853206 2 # CATALYTIC ACTIVITY SRLD_ECOLI D-sorbitol 6-phosphate + NAD(+) = D-fructose 6-phosphate + NADH. # EcoGene EG10971 srlD # GO_function GO:0009010 sorbitol-6-phosphate 2-dehydrogenase activity; IEA:UniProtKB-EC. # GO_process GO:0006062 sorbitol catabolic process; IEA:UniProtKB-UniPathway. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.720 -; 1. # IntAct P05707 3 # InterPro IPR002347 SDR_fam # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR020904 Sc_DH/Rdtase_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00051 Fructose and mannose metabolism # Organism SRLD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR24322 PTHR24322; 2 # PATHWAY Carbohydrate metabolism; D-sorbitol degradation; D- fructose 6-phosphate from D-sorbitol 6-phosphate step 1/1. # PATRIC 32120808 VBIEscCol129921_2796 # PIR E65050 DEECSP # PRINTS PR00080 SDRFAMILY # PRINTS PR00081 GDHRDH # PROSITE PS00061 ADH_SHORT # Pfam PF00106 adh_short # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SRLD_ECOLI Sorbitol-6-phosphate 2-dehydrogenase # RefSeq NP_417185 NC_000913.3 # RefSeq WP_001077358 NZ_LN832404.1 # SIMILARITY Belongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO 0000305}. # SUBUNIT SRLD_ECOLI Homotetramer. # SUPFAM SSF51735 SSF51735 # UniPathway UPA00812 UER00783 # eggNOG COG1028 LUCA # eggNOG ENOG4107QMF Bacteria BLAST swissprot:SRLD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SRLD_ECOLI BioCyc ECOL316407:JW2674-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2674-MONOMER BioCyc EcoCyc:SORB6PDEHYDROG-MONOMER http://biocyc.org/getid?id=EcoCyc:SORB6PDEHYDROG-MONOMER BioCyc MetaCyc:SORB6PDEHYDROG-MONOMER http://biocyc.org/getid?id=MetaCyc:SORB6PDEHYDROG-MONOMER COG COG1028 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1028 DIP DIP-10917N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10917N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.140 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.140 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J02708 http://www.ebi.ac.uk/ena/data/view/J02708 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 ENZYME 1.1.1.140 http://enzyme.expasy.org/EC/1.1.1.140 EchoBASE EB0964 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0964 EcoGene EG10971 http://www.ecogene.org/geneInfo.php?eg_id=EG10971 EnsemblBacteria AAC75747 http://www.ensemblgenomes.org/id/AAC75747 EnsemblBacteria AAC75747 http://www.ensemblgenomes.org/id/AAC75747 EnsemblBacteria BAA16566 http://www.ensemblgenomes.org/id/BAA16566 EnsemblBacteria BAA16566 http://www.ensemblgenomes.org/id/BAA16566 EnsemblBacteria BAA16566 http://www.ensemblgenomes.org/id/BAA16566 EnsemblBacteria b2705 http://www.ensemblgenomes.org/id/b2705 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0009010 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009010 GO_process GO:0006062 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006062 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 948937 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948937 InParanoid P05707 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P05707 IntAct P05707 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P05707* IntEnz 1.1.1.140 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.140 InterPro IPR002347 http://www.ebi.ac.uk/interpro/entry/IPR002347 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR020904 http://www.ebi.ac.uk/interpro/entry/IPR020904 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2674 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2674 KEGG_Gene eco:b2705 http://www.genome.jp/dbget-bin/www_bget?eco:b2705 KEGG_Orthology KO:K00068 http://www.genome.jp/dbget-bin/www_bget?KO:K00068 KEGG_Pathway ko00051 http://www.genome.jp/kegg-bin/show_pathway?ko00051 KEGG_Reaction rn:R05607 http://www.genome.jp/dbget-bin/www_bget?rn:R05607 OMA INTEFGE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=INTEFGE PANTHER PTHR24322 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24322 PRINTS PR00080 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00080 PRINTS PR00081 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00081 PROSITE PS00061 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00061 PSORT swissprot:SRLD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SRLD_ECOLI PSORT-B swissprot:SRLD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SRLD_ECOLI PSORT2 swissprot:SRLD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SRLD_ECOLI Pfam PF00106 http://pfam.xfam.org/family/PF00106 Phobius swissprot:SRLD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SRLD_ECOLI PhylomeDB P05707 http://phylomedb.org/?seqid=P05707 ProteinModelPortal P05707 http://www.proteinmodelportal.org/query/uniprot/P05707 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3553176 http://www.ncbi.nlm.nih.gov/pubmed/3553176 PubMed 6384188 http://www.ncbi.nlm.nih.gov/pubmed/6384188 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417185 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417185 RefSeq WP_001077358 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001077358 SMR P05707 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P05707 STRING 511145.b2705 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2705&targetmode=cogs STRING COG1028 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1028&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB SRLD_ECOLI http://www.uniprot.org/uniprot/SRLD_ECOLI UniProtKB-AC P05707 http://www.uniprot.org/uniprot/P05707 charge swissprot:SRLD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SRLD_ECOLI eggNOG COG1028 http://eggnogapi.embl.de/nog_data/html/tree/COG1028 eggNOG ENOG4107QMF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QMF epestfind swissprot:SRLD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SRLD_ECOLI garnier swissprot:SRLD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SRLD_ECOLI helixturnhelix swissprot:SRLD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SRLD_ECOLI hmoment swissprot:SRLD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SRLD_ECOLI iep swissprot:SRLD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SRLD_ECOLI inforesidue swissprot:SRLD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SRLD_ECOLI octanol swissprot:SRLD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SRLD_ECOLI pepcoil swissprot:SRLD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SRLD_ECOLI pepdigest swissprot:SRLD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SRLD_ECOLI pepinfo swissprot:SRLD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SRLD_ECOLI pepnet swissprot:SRLD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SRLD_ECOLI pepstats swissprot:SRLD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SRLD_ECOLI pepwheel swissprot:SRLD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SRLD_ECOLI pepwindow swissprot:SRLD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SRLD_ECOLI sigcleave swissprot:SRLD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SRLD_ECOLI ## Database ID URL or Descriptions # AltName RIBD_ECOLI HTP reductase # AltName RIBD_ECOLI Riboflavin-specific deaminase # AltName RIBD_ECOLI Riboflavin-specific deaminase # BRENDA 1.1.1.193 2165 # BioGrid 4263249 17 # CATALYTIC ACTIVITY RIBD_ECOLI 2,5-diamino-6-hydroxy-4-(5- phosphoribosylamino)pyrimidine + H(2)O = 5-amino-6-(5- phosphoribosylamino)uracil + NH(3). # CATALYTIC ACTIVITY RIBD_ECOLI 5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) = 5-amino-6-(5-phospho-D-ribosylamino)uracil + NADPH. # COFACTOR RIBD_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000250}; Note=Binds 1 zinc ion. {ECO 0000250}; # EcoGene EG11321 ribD # FUNCTION RIBD_ECOLI Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0008270 zinc ion binding; IEA:InterPro. # GO_function GO:0008703 5-amino-6-(5-phosphoribosylamino)uracil reductase activity; IDA:EcoCyc. # GO_function GO:0008835 diaminohydroxyphosphoribosylaminopyrimidine deaminase activity; IDA:EcoCyc. # GO_function GO:0050661 NADP binding; IDA:EcoCyc. # GO_process GO:0009231 riboflavin biosynthetic process; IDA:EcoCyc. # GO_process GO:0009451 RNA modification; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.430.10 -; 1. # IntAct P25539 34 # InterPro IPR002125 CMP_dCMP_Zn-bd # InterPro IPR002734 RibDG_C # InterPro IPR004794 Eubact_RibD # InterPro IPR011549 RibD_C # InterPro IPR016192 APOBEC/CMP_deaminase_Zn-bd # InterPro IPR016193 Cytidine_deaminase-like # InterPro IPR024072 DHFR-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00740 Riboflavin metabolism # Organism RIBD_ECOLI Escherichia coli (strain K12) # PATHWAY Cofactor biosynthesis; riboflavin biosynthesis; 5-amino- 6-(D-ribitylamino)uracil from GTP step 2/4. # PATHWAY Cofactor biosynthesis; riboflavin biosynthesis; 5-amino- 6-(D-ribitylamino)uracil from GTP step 3/4. # PATRIC 32115977 VBIEscCol129921_0430 # PDB 2G6V X-ray; 2.60 A; A/B=2-367 # PDB 2O7P X-ray; 3.00 A; A/B=2-367 # PDB 2OBC X-ray; 3.00 A; A/B=2-367 # PIR S26201 S26201 # PIRSF PIRSF006769 RibD # PROSITE PS00903 CYT_DCMP_DEAMINASES_1 # PROSITE PS51747 CYT_DCMP_DEAMINASES_2 # Pfam PF00383 dCMP_cyt_deam_1 # Pfam PF01872 RibD_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RIBD_ECOLI 5-amino-6-(5-phosphoribosylamino)uracil reductase # RecName RIBD_ECOLI Diaminohydroxyphosphoribosylaminopyrimidine deaminase # RecName RIBD_ECOLI Riboflavin biosynthesis protein RibD # RecName RIBD_ECOLI Riboflavin biosynthesis protein RibD # RefSeq NP_414948 NC_000913.3 # RefSeq WP_001150457 NZ_LN832404.1 # SIMILARITY Contains 1 CMP/dCMP-type deaminase domain. {ECO:0000255|PROSITE-ProRule PRU01083}. # SIMILARITY In the C-terminal section; belongs to the HTP reductase family. {ECO 0000305}. # SIMILARITY In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family. {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 17765262}. # SUPFAM SSF53597 SSF53597 # SUPFAM SSF53927 SSF53927 # TIGRFAMs TIGR00227 ribD_Cterm # TIGRFAMs TIGR00326 eubact_ribD # UniPathway UPA00275 UER00401 # UniPathway UPA00275 UER00402 # eggNOG COG0117 LUCA # eggNOG COG1985 LUCA # eggNOG ENOG4105D1W Bacteria BLAST swissprot:RIBD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RIBD_ECOLI BioCyc ECOL316407:JW0404-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0404-MONOMER BioCyc EcoCyc:RIBOFLAVINSYNDEAM-MONOMER http://biocyc.org/getid?id=EcoCyc:RIBOFLAVINSYNDEAM-MONOMER BioCyc MetaCyc:RIBOFLAVINSYNDEAM-MONOMER http://biocyc.org/getid?id=MetaCyc:RIBOFLAVINSYNDEAM-MONOMER COG COG0117 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0117 COG COG1985 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1985 DIP DIP-10708N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10708N DOI 10.1007/BF00538702 http://dx.doi.org/10.1007/BF00538702 DOI 10.1016/j.jmb.2006.12.009 http://dx.doi.org/10.1016/j.jmb.2006.12.009 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.193 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.193 EC_number EC:3.5.4.26 http://www.genome.jp/dbget-bin/www_bget?EC:3.5.4.26 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL X64395 http://www.ebi.ac.uk/ena/data/view/X64395 ENZYME 1.1.1.193 http://enzyme.expasy.org/EC/1.1.1.193 ENZYME 3.5.4.26 http://enzyme.expasy.org/EC/3.5.4.26 EchoBASE EB1297 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1297 EcoGene EG11321 http://www.ecogene.org/geneInfo.php?eg_id=EG11321 EnsemblBacteria AAC73517 http://www.ensemblgenomes.org/id/AAC73517 EnsemblBacteria AAC73517 http://www.ensemblgenomes.org/id/AAC73517 EnsemblBacteria BAE76194 http://www.ensemblgenomes.org/id/BAE76194 EnsemblBacteria BAE76194 http://www.ensemblgenomes.org/id/BAE76194 EnsemblBacteria BAE76194 http://www.ensemblgenomes.org/id/BAE76194 EnsemblBacteria b0414 http://www.ensemblgenomes.org/id/b0414 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0008703 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008703 GO_function GO:0008835 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008835 GO_function GO:0050661 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050661 GO_process GO:0009231 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009231 GO_process GO:0009451 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009451 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.430.10 http://www.cathdb.info/version/latest/superfamily/3.40.430.10 GeneID 945620 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945620 HOGENOM HOG000257442 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000257442&db=HOGENOM6 InParanoid P25539 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P25539 IntAct P25539 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P25539* IntEnz 1.1.1.193 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.193 IntEnz 3.5.4.26 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.4.26 InterPro IPR002125 http://www.ebi.ac.uk/interpro/entry/IPR002125 InterPro IPR002734 http://www.ebi.ac.uk/interpro/entry/IPR002734 InterPro IPR004794 http://www.ebi.ac.uk/interpro/entry/IPR004794 InterPro IPR011549 http://www.ebi.ac.uk/interpro/entry/IPR011549 InterPro IPR016192 http://www.ebi.ac.uk/interpro/entry/IPR016192 InterPro IPR016193 http://www.ebi.ac.uk/interpro/entry/IPR016193 InterPro IPR024072 http://www.ebi.ac.uk/interpro/entry/IPR024072 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0404 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0404 KEGG_Gene eco:b0414 http://www.genome.jp/dbget-bin/www_bget?eco:b0414 KEGG_Orthology KO:K11752 http://www.genome.jp/dbget-bin/www_bget?KO:K11752 KEGG_Pathway ko00740 http://www.genome.jp/kegg-bin/show_pathway?ko00740 KEGG_Reaction rn:R03458 http://www.genome.jp/dbget-bin/www_bget?rn:R03458 KEGG_Reaction rn:R03459 http://www.genome.jp/dbget-bin/www_bget?rn:R03459 MINT MINT-1221612 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1221612 OMA GHRWRAR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GHRWRAR PDB 2G6V http://www.ebi.ac.uk/pdbe-srv/view/entry/2G6V PDB 2O7P http://www.ebi.ac.uk/pdbe-srv/view/entry/2O7P PDB 2OBC http://www.ebi.ac.uk/pdbe-srv/view/entry/2OBC PDBsum 2G6V http://www.ebi.ac.uk/pdbsum/2G6V PDBsum 2O7P http://www.ebi.ac.uk/pdbsum/2O7P PDBsum 2OBC http://www.ebi.ac.uk/pdbsum/2OBC PROSITE PS00903 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00903 PROSITE PS51747 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51747 PSORT swissprot:RIBD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RIBD_ECOLI PSORT-B swissprot:RIBD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RIBD_ECOLI PSORT2 swissprot:RIBD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RIBD_ECOLI Pfam PF00383 http://pfam.xfam.org/family/PF00383 Pfam PF01872 http://pfam.xfam.org/family/PF01872 Phobius swissprot:RIBD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RIBD_ECOLI PhylomeDB P25539 http://phylomedb.org/?seqid=P25539 ProteinModelPortal P25539 http://www.proteinmodelportal.org/query/uniprot/P25539 PubMed 1406588 http://www.ncbi.nlm.nih.gov/pubmed/1406588 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17765262 http://www.ncbi.nlm.nih.gov/pubmed/17765262 PubMed 9068650 http://www.ncbi.nlm.nih.gov/pubmed/9068650 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414948 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414948 RefSeq WP_001150457 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001150457 SMR P25539 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P25539 STRING 511145.b0414 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0414&targetmode=cogs STRING COG0117 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0117&targetmode=cogs STRING COG1985 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1985&targetmode=cogs SUPFAM SSF53597 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53597 SUPFAM SSF53927 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53927 TIGRFAMs TIGR00227 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00227 TIGRFAMs TIGR00326 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00326 UniProtKB RIBD_ECOLI http://www.uniprot.org/uniprot/RIBD_ECOLI UniProtKB-AC P25539 http://www.uniprot.org/uniprot/P25539 charge swissprot:RIBD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RIBD_ECOLI eggNOG COG0117 http://eggnogapi.embl.de/nog_data/html/tree/COG0117 eggNOG COG1985 http://eggnogapi.embl.de/nog_data/html/tree/COG1985 eggNOG ENOG4105D1W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D1W epestfind swissprot:RIBD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RIBD_ECOLI garnier swissprot:RIBD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RIBD_ECOLI helixturnhelix swissprot:RIBD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RIBD_ECOLI hmoment swissprot:RIBD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RIBD_ECOLI iep swissprot:RIBD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RIBD_ECOLI inforesidue swissprot:RIBD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RIBD_ECOLI octanol swissprot:RIBD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RIBD_ECOLI pepcoil swissprot:RIBD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RIBD_ECOLI pepdigest swissprot:RIBD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RIBD_ECOLI pepinfo swissprot:RIBD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RIBD_ECOLI pepnet swissprot:RIBD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RIBD_ECOLI pepstats swissprot:RIBD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RIBD_ECOLI pepwheel swissprot:RIBD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RIBD_ECOLI pepwindow swissprot:RIBD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RIBD_ECOLI sigcleave swissprot:RIBD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RIBD_ECOLI ## Database ID URL or Descriptions # Organism YUAN_ECOLI Escherichia coli (strain K12) # RecName YUAN_ECOLI Uncharacterized protein YuaN # RefSeq NP_061404 NC_002483.1 # RefSeq WP_010892527 NC_002483.1 BLAST swissprot:YUAN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YUAN_ECOLI EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1263501 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263501 PSORT swissprot:YUAN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YUAN_ECOLI PSORT-B swissprot:YUAN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YUAN_ECOLI PSORT2 swissprot:YUAN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YUAN_ECOLI Phobius swissprot:YUAN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YUAN_ECOLI ProteinModelPortal Q9JMS6 http://www.proteinmodelportal.org/query/uniprot/Q9JMS6 RefSeq NP_061404 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061404 RefSeq WP_010892527 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_010892527 UniProtKB YUAN_ECOLI http://www.uniprot.org/uniprot/YUAN_ECOLI UniProtKB-AC Q9JMS6 http://www.uniprot.org/uniprot/Q9JMS6 charge swissprot:YUAN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YUAN_ECOLI epestfind swissprot:YUAN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YUAN_ECOLI garnier swissprot:YUAN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YUAN_ECOLI helixturnhelix swissprot:YUAN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YUAN_ECOLI hmoment swissprot:YUAN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YUAN_ECOLI iep swissprot:YUAN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YUAN_ECOLI inforesidue swissprot:YUAN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YUAN_ECOLI octanol swissprot:YUAN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YUAN_ECOLI pepcoil swissprot:YUAN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YUAN_ECOLI pepdigest swissprot:YUAN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YUAN_ECOLI pepinfo swissprot:YUAN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YUAN_ECOLI pepnet swissprot:YUAN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YUAN_ECOLI pepstats swissprot:YUAN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YUAN_ECOLI pepwheel swissprot:YUAN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YUAN_ECOLI pepwindow swissprot:YUAN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YUAN_ECOLI sigcleave swissprot:YUAN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YUAN_ECOLI ## Database ID URL or Descriptions # AltName Y3808_ECOLI CyaX # AltName Y3808_ECOLI O161 # BioGrid 4262611 13 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # IntAct P11291 4 # InterPro IPR016498 UCP006864 # Organism Y3808_ECOLI Escherichia coli (strain K12) # PIR S30698 S30698 # PIRSF PIRSF006864 UCP006864 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Y3808_ECOLI Putative uncharacterized protein b3808 BLAST swissprot:Y3808_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:Y3808_ECOLI BioCyc ECOL316407:JW3780-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3780-MONOMER BioCyc EcoCyc:G7802-MONOMER http://biocyc.org/getid?id=EcoCyc:G7802-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/12.24.9427 http://dx.doi.org/10.1093/nar/12.24.9427 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X01653 http://www.ebi.ac.uk/ena/data/view/X01653 EnsemblBacteria BAE77493 http://www.ensemblgenomes.org/id/BAE77493 EnsemblBacteria BAE77493 http://www.ensemblgenomes.org/id/BAE77493 EnsemblBacteria BAE77493 http://www.ensemblgenomes.org/id/BAE77493 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 IntAct P11291 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P11291* InterPro IPR016498 http://www.ebi.ac.uk/interpro/entry/IPR016498 KEGG_Gene ecj:JW3780 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3780 OMA SLCGERF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SLCGERF PSORT swissprot:Y3808_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:Y3808_ECOLI PSORT-B swissprot:Y3808_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:Y3808_ECOLI PSORT2 swissprot:Y3808_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:Y3808_ECOLI Phobius swissprot:Y3808_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:Y3808_ECOLI ProteinModelPortal P11291 http://www.proteinmodelportal.org/query/uniprot/P11291 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6393056 http://www.ncbi.nlm.nih.gov/pubmed/6393056 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 STRING 316407.85676243 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85676243&targetmode=cogs UniProtKB Y3808_ECOLI http://www.uniprot.org/uniprot/Y3808_ECOLI UniProtKB-AC P11291 http://www.uniprot.org/uniprot/P11291 charge swissprot:Y3808_ECOLI http://rest.g-language.org/emboss/charge/swissprot:Y3808_ECOLI epestfind swissprot:Y3808_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:Y3808_ECOLI garnier swissprot:Y3808_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:Y3808_ECOLI helixturnhelix swissprot:Y3808_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:Y3808_ECOLI hmoment swissprot:Y3808_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:Y3808_ECOLI iep swissprot:Y3808_ECOLI http://rest.g-language.org/emboss/iep/swissprot:Y3808_ECOLI inforesidue swissprot:Y3808_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:Y3808_ECOLI octanol swissprot:Y3808_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:Y3808_ECOLI pepcoil swissprot:Y3808_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:Y3808_ECOLI pepdigest swissprot:Y3808_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:Y3808_ECOLI pepinfo swissprot:Y3808_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:Y3808_ECOLI pepnet swissprot:Y3808_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:Y3808_ECOLI pepstats swissprot:Y3808_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:Y3808_ECOLI pepwheel swissprot:Y3808_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:Y3808_ECOLI pepwindow swissprot:Y3808_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:Y3808_ECOLI sigcleave swissprot:Y3808_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:Y3808_ECOLI ## Database ID URL or Descriptions # BioGrid 4260917 8 # CDD cd04458 CSP_CDS # EcoGene EG14243 cspG # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0009409 response to cold; IDA:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # INDUCTION CSPG_ECOLI In response to low temperature. # INTERACTION CSPG_ECOLI P0A7L0 rplA; NbExp=2; IntAct=EBI-547581, EBI-543771; # IntAct P0A978 23 # InterPro IPR002059 CSP_DNA-bd # InterPro IPR011129 Cold_shock_prot # InterPro IPR012156 Cold_shock_CspA # InterPro IPR012340 NA-bd_OB-fold # InterPro IPR019844 Cold-shock_CS # KEGG_Brite ko03000 Transcription factors # Organism CSPG_ECOLI Escherichia coli (strain K12) # PATRIC 32117205 VBIEscCol129921_1026 # PIR D64840 D64840 # PIRSF PIRSF002599 Cold_shock_A # PRINTS PR00050 COLDSHOCK # PROSITE PS00352 COLD_SHOCK # Pfam PF00313 CSD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CSPG_ECOLI Cold shock-like protein CspG # RefSeq NP_415510 NC_000913.3 # RefSeq WP_000066490 NZ_LN832404.1 # SIMILARITY Contains 1 CSD (cold-shock) domain. {ECO 0000305}. # SMART SM00357 CSP # SUBCELLULAR LOCATION CSPG_ECOLI Cytoplasm {ECO 0000250}. # SUPFAM SSF50249 SSF50249 # eggNOG COG1278 LUCA # eggNOG ENOG4105VEQ Bacteria BLAST swissprot:CSPG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CSPG_ECOLI BioCyc ECOL316407:JW0974-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0974-MONOMER BioCyc EcoCyc:G6511-MONOMER http://biocyc.org/getid?id=EcoCyc:G6511-MONOMER COG COG1278 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1278 DIP DIP-47938N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47938N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/sj.jim.2900463 http://dx.doi.org/10.1038/sj.jim.2900463 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AF003591 http://www.ebi.ac.uk/ena/data/view/AF003591 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D63344 http://www.ebi.ac.uk/ena/data/view/D63344 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3993 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3993 EcoGene EG14243 http://www.ecogene.org/geneInfo.php?eg_id=EG14243 EnsemblBacteria AAC74075 http://www.ensemblgenomes.org/id/AAC74075 EnsemblBacteria AAC74075 http://www.ensemblgenomes.org/id/AAC74075 EnsemblBacteria BAA35756 http://www.ensemblgenomes.org/id/BAA35756 EnsemblBacteria BAA35756 http://www.ensemblgenomes.org/id/BAA35756 EnsemblBacteria BAA35756 http://www.ensemblgenomes.org/id/BAA35756 EnsemblBacteria b0990 http://www.ensemblgenomes.org/id/b0990 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0009409 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009409 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 945591 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945591 HOGENOM HOG000070674 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000070674&db=HOGENOM6 InParanoid P0A978 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A978 IntAct P0A978 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A978* InterPro IPR002059 http://www.ebi.ac.uk/interpro/entry/IPR002059 InterPro IPR011129 http://www.ebi.ac.uk/interpro/entry/IPR011129 InterPro IPR012156 http://www.ebi.ac.uk/interpro/entry/IPR012156 InterPro IPR012340 http://www.ebi.ac.uk/interpro/entry/IPR012340 InterPro IPR019844 http://www.ebi.ac.uk/interpro/entry/IPR019844 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW0974 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0974 KEGG_Gene eco:b0990 http://www.genome.jp/dbget-bin/www_bget?eco:b0990 KEGG_Orthology KO:K03704 http://www.genome.jp/dbget-bin/www_bget?KO:K03704 MINT MINT-1247768 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1247768 OMA NDKVEFT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NDKVEFT PRINTS PR00050 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00050 PROSITE PS00352 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00352 PSORT swissprot:CSPG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CSPG_ECOLI PSORT-B swissprot:CSPG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CSPG_ECOLI PSORT2 swissprot:CSPG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CSPG_ECOLI Pfam PF00313 http://pfam.xfam.org/family/PF00313 Phobius swissprot:CSPG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CSPG_ECOLI PhylomeDB P0A978 http://phylomedb.org/?seqid=P0A978 ProteinModelPortal P0A978 http://www.proteinmodelportal.org/query/uniprot/P0A978 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8631696 http://www.ncbi.nlm.nih.gov/pubmed/8631696 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9439003 http://www.ncbi.nlm.nih.gov/pubmed/9439003 RefSeq NP_415510 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415510 RefSeq WP_000066490 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000066490 SMART SM00357 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00357 SMR P0A978 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A978 STRING 511145.b0990 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0990&targetmode=cogs STRING COG1278 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1278&targetmode=cogs SUPFAM SSF50249 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50249 UniProtKB CSPG_ECOLI http://www.uniprot.org/uniprot/CSPG_ECOLI UniProtKB-AC P0A978 http://www.uniprot.org/uniprot/P0A978 charge swissprot:CSPG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CSPG_ECOLI eggNOG COG1278 http://eggnogapi.embl.de/nog_data/html/tree/COG1278 eggNOG ENOG4105VEQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VEQ epestfind swissprot:CSPG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CSPG_ECOLI garnier swissprot:CSPG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CSPG_ECOLI helixturnhelix swissprot:CSPG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CSPG_ECOLI hmoment swissprot:CSPG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CSPG_ECOLI iep swissprot:CSPG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CSPG_ECOLI inforesidue swissprot:CSPG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CSPG_ECOLI octanol swissprot:CSPG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CSPG_ECOLI pepcoil swissprot:CSPG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CSPG_ECOLI pepdigest swissprot:CSPG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CSPG_ECOLI pepinfo swissprot:CSPG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CSPG_ECOLI pepnet swissprot:CSPG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CSPG_ECOLI pepstats swissprot:CSPG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CSPG_ECOLI pepwheel swissprot:CSPG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CSPG_ECOLI pepwindow swissprot:CSPG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CSPG_ECOLI sigcleave swissprot:CSPG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CSPG_ECOLI ## Database ID URL or Descriptions # AltName 7-keto-8-amino-pelargonic acid synthase {ECO:0000303|PubMed 3058702} # AltName BIOF_ECOLI 8-amino-7-ketopelargonate synthase # BIOPHYSICOCHEMICAL PROPERTIES BIOF_ECOLI Kinetic parameters KM=25 uM for pimeloyl-CoA (at pH 7.5 and at 30 degrees Celsius) {ECO 0000269|PubMed 10642176}; KM=0.5 uM for L-alanine (at pH 7.5 and at 30 degrees Celsius) {ECO 0000269|PubMed 10642176}; # BRENDA 2.3.1.47 2026 # BioGrid 4259953 17 # CATALYTIC ACTIVITY BIOF_ECOLI Pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO(2) + holo-[acyl-carrier protein]. {ECO 0000269|PubMed 10642176, ECO 0000269|PubMed 20693992}. # COFACTOR BIOF_ECOLI Name=pyridoxal 5'-phosphate; Xref=ChEBI CHEBI 597326; Evidence={ECO 0000269|PubMed 10642176}; # ENZYME REGULATION Competitively inhibited by D-alanine, 8-amino- 7-hydroxy-8-phosphonononanoic acid and 2-amino-3-hydroxy-2- methylnonadioic acid. {ECO:0000269|PubMed 9914476}. # EcoGene EG10121 bioF # FUNCTION BIOF_ECOLI Catalyzes the decarboxylative condensation of pimeloyl- [acyl-carrier protein] and L-alanine to produce 8-amino-7- oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. Can also use pimeloyl-CoA instead of pimeloyl-ACP as substrate, but it is believed that pimeloyl-ACP rather than pimeloyl-CoA is the physiological substrate of BioF. {ECO 0000269|PubMed 10642176, ECO 0000269|PubMed 20693992}. # GO_function GO:0008710 8-amino-7-oxononanoate synthase activity; IDA:EcoCyc. # GO_function GO:0030170 pyridoxal phosphate binding; IDA:UniProtKB. # GO_process GO:0009102 biotin biosynthetic process; IMP:EcoCyc. # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.640.10 -; 1. # Gene3D 3.90.1150.10 -; 1. # HAMAP MF_01693 BioF_aminotrans_2 # IntAct P12998 2 # InterPro IPR001917 Aminotrans_II_pyridoxalP_BS # InterPro IPR004723 AONS_Archaea/Proteobacteria # InterPro IPR004839 Aminotransferase_I/II # InterPro IPR015421 PyrdxlP-dep_Trfase_major_sub1 # InterPro IPR015422 PyrdxlP-dep_Trfase_major_sub2 # InterPro IPR015424 PyrdxlP-dep_Trfase # InterPro IPR022834 AONS_Proteobacteria # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01007 Amino acid related enzymes # KEGG_Pathway ko00780 Biotin metabolism # MASS SPECTROMETRY Mass=41464.4; Mass_error=4.5; Method=Electrospray; Range=2-384; Evidence={ECO:0000269|PubMed 10642176}; # Organism BIOF_ECOLI Escherichia coli (strain K12) # PATHWAY Cofactor biosynthesis; biotin biosynthesis. {ECO:0000305|PubMed 3058702}. # PATRIC 32116753 VBIEscCol129921_0802 # PDB 1BS0 X-ray; 1.65 A; A=1-384 # PDB 1DJ9 X-ray; 2.00 A; A=1-384 # PDB 1DJE X-ray; 1.71 A; A=1-384 # PDB 2G6W X-ray; 2.14 A; A=1-384 # PIR D32025 SYECKP # PROSITE PS00599 AA_TRANSFER_CLASS_2 # Pfam PF00155 Aminotran_1_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 8-amino-7-oxononanoate synthase {ECO:0000303|PubMed 10642176} # RefSeq NP_415297 NC_000913.3 # RefSeq WP_000118826 NZ_LN832404.1 # SIMILARITY Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily. {ECO 0000305}. # SUBUNIT BIOF_ECOLI Homodimer. {ECO 0000269|PubMed 10642176, ECO 0000269|PubMed 16557306, ECO 0000269|PubMed 9813126}. # SUPFAM SSF53383 SSF53383 # TIGRFAMs TIGR00858 bioF # eggNOG COG0156 LUCA # eggNOG ENOG4107EEK Bacteria BLAST swissprot:BIOF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BIOF_ECOLI BioCyc ECOL316407:JW0759-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0759-MONOMER BioCyc EcoCyc:7KAPSYN-MONOMER http://biocyc.org/getid?id=EcoCyc:7KAPSYN-MONOMER BioCyc MetaCyc:7KAPSYN-MONOMER http://biocyc.org/getid?id=MetaCyc:7KAPSYN-MONOMER COG COG0156 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0156 DIP DIP-6870N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-6870N DOI 10.1006/jmbi.1998.2086 http://dx.doi.org/10.1006/jmbi.1998.2086 DOI 10.1021/bi991620j http://dx.doi.org/10.1021/bi991620j DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nchembio.420 http://dx.doi.org/10.1038/nchembio.420 DOI 10.1039/b517922j http://dx.doi.org/10.1039/b517922j DOI 10.1046/j.1432-1327.1999.00006.x http://dx.doi.org/10.1046/j.1432-1327.1999.00006.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.47 {ECO:0000269|PubMed:10642176, ECO:0000269|PubMed:20693992} http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.47 {ECO:0000269|PubMed:10642176, ECO:0000269|PubMed:20693992} EMBL A11542 http://www.ebi.ac.uk/ena/data/view/A11542 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J04423 http://www.ebi.ac.uk/ena/data/view/J04423 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.3.1.47 {ECO:0000269|PubMed:10642176, ECO:0000269|PubMed:20693992} http://enzyme.expasy.org/EC/2.3.1.47 {ECO:0000269|PubMed:10642176, ECO:0000269|PubMed:20693992} EchoBASE EB0119 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0119 EcoGene EG10121 http://www.ecogene.org/geneInfo.php?eg_id=EG10121 EnsemblBacteria AAC73863 http://www.ensemblgenomes.org/id/AAC73863 EnsemblBacteria AAC73863 http://www.ensemblgenomes.org/id/AAC73863 EnsemblBacteria BAE76363 http://www.ensemblgenomes.org/id/BAE76363 EnsemblBacteria BAE76363 http://www.ensemblgenomes.org/id/BAE76363 EnsemblBacteria BAE76363 http://www.ensemblgenomes.org/id/BAE76363 EnsemblBacteria b0776 http://www.ensemblgenomes.org/id/b0776 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008710 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008710 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_process GO:0009102 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009102 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.640.10 http://www.cathdb.info/version/latest/superfamily/3.40.640.10 Gene3D 3.90.1150.10 http://www.cathdb.info/version/latest/superfamily/3.90.1150.10 GeneID 945384 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945384 HAMAP MF_01693 http://hamap.expasy.org/unirule/MF_01693 HOGENOM HOG000221021 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000221021&db=HOGENOM6 InParanoid P12998 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P12998 IntAct P12998 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P12998* IntEnz 2.3.1.47 {ECO:0000269|PubMed:10642176, ECO:0000269|PubMed:20693992} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.47 {ECO:0000269|PubMed:10642176, ECO:0000269|PubMed:20693992} InterPro IPR001917 http://www.ebi.ac.uk/interpro/entry/IPR001917 InterPro IPR004723 http://www.ebi.ac.uk/interpro/entry/IPR004723 InterPro IPR004839 http://www.ebi.ac.uk/interpro/entry/IPR004839 InterPro IPR015421 http://www.ebi.ac.uk/interpro/entry/IPR015421 InterPro IPR015422 http://www.ebi.ac.uk/interpro/entry/IPR015422 InterPro IPR015424 http://www.ebi.ac.uk/interpro/entry/IPR015424 InterPro IPR022834 http://www.ebi.ac.uk/interpro/entry/IPR022834 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Gene ecj:JW0759 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0759 KEGG_Gene eco:b0776 http://www.genome.jp/dbget-bin/www_bget?eco:b0776 KEGG_Orthology KO:K00652 http://www.genome.jp/dbget-bin/www_bget?KO:K00652 KEGG_Pathway ko00780 http://www.genome.jp/kegg-bin/show_pathway?ko00780 KEGG_Reaction rn:R03210 http://www.genome.jp/dbget-bin/www_bget?rn:R03210 KEGG_Reaction rn:R10124 http://www.genome.jp/dbget-bin/www_bget?rn:R10124 OMA ELAHACI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ELAHACI PDB 1BS0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1BS0 PDB 1DJ9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1DJ9 PDB 1DJE http://www.ebi.ac.uk/pdbe-srv/view/entry/1DJE PDB 2G6W http://www.ebi.ac.uk/pdbe-srv/view/entry/2G6W PDBsum 1BS0 http://www.ebi.ac.uk/pdbsum/1BS0 PDBsum 1DJ9 http://www.ebi.ac.uk/pdbsum/1DJ9 PDBsum 1DJE http://www.ebi.ac.uk/pdbsum/1DJE PDBsum 2G6W http://www.ebi.ac.uk/pdbsum/2G6W PROSITE PS00599 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00599 PSORT swissprot:BIOF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BIOF_ECOLI PSORT-B swissprot:BIOF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BIOF_ECOLI PSORT2 swissprot:BIOF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BIOF_ECOLI Pfam PF00155 http://pfam.xfam.org/family/PF00155 Phobius swissprot:BIOF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BIOF_ECOLI PhylomeDB P12998 http://phylomedb.org/?seqid=P12998 ProteinModelPortal P12998 http://www.proteinmodelportal.org/query/uniprot/P12998 PubMed 10642176 http://www.ncbi.nlm.nih.gov/pubmed/10642176 PubMed 16557306 http://www.ncbi.nlm.nih.gov/pubmed/16557306 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20693992 http://www.ncbi.nlm.nih.gov/pubmed/20693992 PubMed 3058702 http://www.ncbi.nlm.nih.gov/pubmed/3058702 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9813126 http://www.ncbi.nlm.nih.gov/pubmed/9813126 PubMed 9914476 http://www.ncbi.nlm.nih.gov/pubmed/9914476 RefSeq NP_415297 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415297 RefSeq WP_000118826 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000118826 SMR P12998 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P12998 STRING 511145.b0776 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0776&targetmode=cogs STRING COG0156 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0156&targetmode=cogs SUPFAM SSF53383 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53383 TIGRFAMs TIGR00858 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00858 UniProtKB BIOF_ECOLI http://www.uniprot.org/uniprot/BIOF_ECOLI UniProtKB-AC P12998 http://www.uniprot.org/uniprot/P12998 charge swissprot:BIOF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BIOF_ECOLI eggNOG COG0156 http://eggnogapi.embl.de/nog_data/html/tree/COG0156 eggNOG ENOG4107EEK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107EEK epestfind swissprot:BIOF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BIOF_ECOLI garnier swissprot:BIOF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BIOF_ECOLI helixturnhelix swissprot:BIOF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BIOF_ECOLI hmoment swissprot:BIOF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BIOF_ECOLI iep swissprot:BIOF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BIOF_ECOLI inforesidue swissprot:BIOF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BIOF_ECOLI octanol swissprot:BIOF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BIOF_ECOLI pepcoil swissprot:BIOF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BIOF_ECOLI pepdigest swissprot:BIOF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BIOF_ECOLI pepinfo swissprot:BIOF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BIOF_ECOLI pepnet swissprot:BIOF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BIOF_ECOLI pepstats swissprot:BIOF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BIOF_ECOLI pepwheel swissprot:BIOF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BIOF_ECOLI pepwindow swissprot:BIOF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BIOF_ECOLI sigcleave swissprot:BIOF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BIOF_ECOLI ## Database ID URL or Descriptions # EcoGene EG13769 ydcZ # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR006750 YdcZ # KEGG_Brite ko02000 Transporters # Organism YDCZ_ECOLI Escherichia coli (strain K12) # PATRIC 32118186 VBIEscCol129921_1513 # PIR B64897 B64897 # Pfam PF04657 DMT_YdcZ # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDCZ_ECOLI Inner membrane protein YdcZ # RefSeq NP_415964 NC_000913.3 # RefSeq WP_001076535 NZ_LN832404.1 # SUBCELLULAR LOCATION YDCZ_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.7.21 the drug/metabolite transporter (dmt) superfamily # eggNOG COG3238 LUCA # eggNOG ENOG4108T9Y Bacteria BLAST swissprot:YDCZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDCZ_ECOLI BioCyc ECOL316407:JW1442-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1442-MONOMER BioCyc EcoCyc:G6758-MONOMER http://biocyc.org/getid?id=EcoCyc:G6758-MONOMER COG COG3238 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3238 DIP DIP-11659N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11659N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3532 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3532 EcoGene EG13769 http://www.ecogene.org/geneInfo.php?eg_id=EG13769 EnsemblBacteria AAC74529 http://www.ensemblgenomes.org/id/AAC74529 EnsemblBacteria AAC74529 http://www.ensemblgenomes.org/id/AAC74529 EnsemblBacteria BAE76443 http://www.ensemblgenomes.org/id/BAE76443 EnsemblBacteria BAE76443 http://www.ensemblgenomes.org/id/BAE76443 EnsemblBacteria BAE76443 http://www.ensemblgenomes.org/id/BAE76443 EnsemblBacteria b1447 http://www.ensemblgenomes.org/id/b1447 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 946008 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946008 HOGENOM HOG000120609 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120609&db=HOGENOM6 InParanoid P76111 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76111 IntAct P76111 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76111* InterPro IPR006750 http://www.ebi.ac.uk/interpro/entry/IPR006750 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1442 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1442 KEGG_Gene eco:b1447 http://www.genome.jp/dbget-bin/www_bget?eco:b1447 KEGG_Orthology KO:K09936 http://www.genome.jp/dbget-bin/www_bget?KO:K09936 OMA ISGYQYV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ISGYQYV PSORT swissprot:YDCZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDCZ_ECOLI PSORT-B swissprot:YDCZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDCZ_ECOLI PSORT2 swissprot:YDCZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDCZ_ECOLI Pfam PF04657 http://pfam.xfam.org/family/PF04657 Phobius swissprot:YDCZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDCZ_ECOLI ProteinModelPortal P76111 http://www.proteinmodelportal.org/query/uniprot/P76111 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415964 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415964 RefSeq WP_001076535 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001076535 STRING 511145.b1447 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1447&targetmode=cogs STRING COG3238 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3238&targetmode=cogs TCDB 2.A.7.21 http://www.tcdb.org/search/result.php?tc=2.A.7.21 UniProtKB YDCZ_ECOLI http://www.uniprot.org/uniprot/YDCZ_ECOLI UniProtKB-AC P76111 http://www.uniprot.org/uniprot/P76111 charge swissprot:YDCZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDCZ_ECOLI eggNOG COG3238 http://eggnogapi.embl.de/nog_data/html/tree/COG3238 eggNOG ENOG4108T9Y http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108T9Y epestfind swissprot:YDCZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDCZ_ECOLI garnier swissprot:YDCZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDCZ_ECOLI helixturnhelix swissprot:YDCZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDCZ_ECOLI hmoment swissprot:YDCZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDCZ_ECOLI iep swissprot:YDCZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDCZ_ECOLI inforesidue swissprot:YDCZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDCZ_ECOLI octanol swissprot:YDCZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDCZ_ECOLI pepcoil swissprot:YDCZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDCZ_ECOLI pepdigest swissprot:YDCZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDCZ_ECOLI pepinfo swissprot:YDCZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDCZ_ECOLI pepnet swissprot:YDCZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDCZ_ECOLI pepstats swissprot:YDCZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDCZ_ECOLI pepwheel swissprot:YDCZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDCZ_ECOLI pepwindow swissprot:YDCZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDCZ_ECOLI sigcleave swissprot:YDCZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDCZ_ECOLI ## Database ID URL or Descriptions # AltName PGSA_ECOLI Phosphatidylglycerophosphate synthase # BioGrid 4261587 230 # CATALYTIC ACTIVITY PGSA_ECOLI CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate. # EcoGene EG10706 pgsA # FUNCTION PGSA_ECOLI This protein catalyzes the committed step to the synthesis of the acidic phospholipids. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; ISM:EcoliWiki. # GO_component GO:0016021 integral component of membrane; IDA:EcoliWiki. # GO_function GO:0008444 CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity; IBA:GO_Central. # GO_process GO:0006655 phosphatidylglycerol biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0046474 glycerophospholipid biosynthetic process; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # HAMAP MF_01437 PgsA # InterPro IPR000462 CDP-OH_P_trans # InterPro IPR004570 Phosphatidylglycerol_P_synth # InterPro IPR023762 PGP_synthase_bac # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00564 Glycerophospholipid metabolism # Organism PGSA_ECOLI Escherichia coli (strain K12) # PATHWAY Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol step 1/2. # PATRIC 32119157 VBIEscCol129921_1993 # PIR E64954 XNECPG # PIRSF PIRSF000847 Phos_ph_gly_syn # PROSITE PS00379 CDP_ALCOHOL_P_TRANSF # Pfam PF01066 CDP-OH_P_transf # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PGSA_ECOLI CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase # RefSeq NP_416422 NC_000913.3 # RefSeq WP_001160187 NZ_LN832404.1 # SIMILARITY Belongs to the CDP-alcohol phosphatidyltransferase class-I family. {ECO 0000305}. # SUBCELLULAR LOCATION PGSA_ECOLI Cell inner membrane; Multi-pass membrane protein. # TIGRFAMs TIGR00560 pgsA # UniPathway UPA00084 UER00503 # eggNOG COG0558 LUCA # eggNOG ENOG4105BZQ Bacteria BLAST swissprot:PGSA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PGSA_ECOLI BioCyc ECOL316407:JW1897-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1897-MONOMER BioCyc EcoCyc:PHOSPHAGLYPSYN-MONOMER http://biocyc.org/getid?id=EcoCyc:PHOSPHAGLYPSYN-MONOMER BioCyc MetaCyc:PHOSPHAGLYPSYN-MONOMER http://biocyc.org/getid?id=MetaCyc:PHOSPHAGLYPSYN-MONOMER COG COG0558 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0558 DOI 10.1016/0076-6879(92)09039-6 http://dx.doi.org/10.1016/0076-6879(92)09039-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1111/j.1432-1033.1996.00489.x http://dx.doi.org/10.1111/j.1432-1033.1996.00489.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.8.5 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.8.5 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M12299 http://www.ebi.ac.uk/ena/data/view/M12299 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.8.5 http://enzyme.expasy.org/EC/2.7.8.5 EchoBASE EB0700 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0700 EcoGene EG10706 http://www.ecogene.org/geneInfo.php?eg_id=EG10706 EnsemblBacteria AAC74979 http://www.ensemblgenomes.org/id/AAC74979 EnsemblBacteria AAC74979 http://www.ensemblgenomes.org/id/AAC74979 EnsemblBacteria BAA15732 http://www.ensemblgenomes.org/id/BAA15732 EnsemblBacteria BAA15732 http://www.ensemblgenomes.org/id/BAA15732 EnsemblBacteria BAA15732 http://www.ensemblgenomes.org/id/BAA15732 EnsemblBacteria b1912 http://www.ensemblgenomes.org/id/b1912 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008444 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008444 GO_process GO:0006655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006655 GO_process GO:0046474 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046474 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 945791 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945791 HAMAP MF_01437 http://hamap.expasy.org/unirule/MF_01437 HOGENOM HOG000010898 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000010898&db=HOGENOM6 InParanoid P0ABF8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABF8 IntAct P0ABF8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABF8* IntEnz 2.7.8.5 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.8.5 InterPro IPR000462 http://www.ebi.ac.uk/interpro/entry/IPR000462 InterPro IPR004570 http://www.ebi.ac.uk/interpro/entry/IPR004570 InterPro IPR023762 http://www.ebi.ac.uk/interpro/entry/IPR023762 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1897 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1897 KEGG_Gene eco:b1912 http://www.genome.jp/dbget-bin/www_bget?eco:b1912 KEGG_Orthology KO:K00995 http://www.genome.jp/dbget-bin/www_bget?KO:K00995 KEGG_Pathway ko00564 http://www.genome.jp/kegg-bin/show_pathway?ko00564 KEGG_Reaction rn:R01801 http://www.genome.jp/dbget-bin/www_bget?rn:R01801 OMA QMVAIPF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QMVAIPF PROSITE PS00379 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00379 PSORT swissprot:PGSA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PGSA_ECOLI PSORT-B swissprot:PGSA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PGSA_ECOLI PSORT2 swissprot:PGSA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PGSA_ECOLI Pfam PF01066 http://pfam.xfam.org/family/PF01066 Phobius swissprot:PGSA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PGSA_ECOLI PhylomeDB P0ABF8 http://phylomedb.org/?seqid=P0ABF8 ProteinModelPortal P0ABF8 http://www.proteinmodelportal.org/query/uniprot/P0ABF8 PubMed 1323047 http://www.ncbi.nlm.nih.gov/pubmed/1323047 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3003065 http://www.ncbi.nlm.nih.gov/pubmed/3003065 PubMed 8195097 http://www.ncbi.nlm.nih.gov/pubmed/8195097 PubMed 8917447 http://www.ncbi.nlm.nih.gov/pubmed/8917447 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416422 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416422 RefSeq WP_001160187 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001160187 SMR P0ABF8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABF8 STRING 511145.b1912 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1912&targetmode=cogs STRING COG0558 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0558&targetmode=cogs TIGRFAMs TIGR00560 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00560 UniProtKB PGSA_ECOLI http://www.uniprot.org/uniprot/PGSA_ECOLI UniProtKB-AC P0ABF8 http://www.uniprot.org/uniprot/P0ABF8 charge swissprot:PGSA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PGSA_ECOLI eggNOG COG0558 http://eggnogapi.embl.de/nog_data/html/tree/COG0558 eggNOG ENOG4105BZQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZQ epestfind swissprot:PGSA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PGSA_ECOLI garnier swissprot:PGSA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PGSA_ECOLI helixturnhelix swissprot:PGSA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PGSA_ECOLI hmoment swissprot:PGSA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PGSA_ECOLI iep swissprot:PGSA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PGSA_ECOLI inforesidue swissprot:PGSA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PGSA_ECOLI octanol swissprot:PGSA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PGSA_ECOLI pepcoil swissprot:PGSA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PGSA_ECOLI pepdigest swissprot:PGSA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PGSA_ECOLI pepinfo swissprot:PGSA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PGSA_ECOLI pepnet swissprot:PGSA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PGSA_ECOLI pepstats swissprot:PGSA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PGSA_ECOLI pepwheel swissprot:PGSA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PGSA_ECOLI pepwindow swissprot:PGSA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PGSA_ECOLI sigcleave swissprot:PGSA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PGSA_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES Temperature dependence: The MqsR-MqsA complex is exceptionally thermostable with a Tm of 83.4 degress Celsius versus 48.1 degress Celsius for MqsR and 61.1 degress Celsius for MqsA. {ECO 0000269|PubMed:23172222}; # BioGrid 4259247 153 # COFACTOR MQSA_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 20041169, ECO 0000269|PubMed 20823526, ECO 0000269|PubMed 21068382, ECO 0000269|PubMed 22789559}; Note=Binds 1 Zn(2+) ion per subunit. {ECO 0000269|PubMed 20041169, ECO 0000269|PubMed 20823526, ECO 0000269|PubMed 21068382, ECO 0000269|PubMed 22789559}; # DISRUPTION PHENOTYPE MQSA_ECOLI Essential for growth, it cannot be disrupted (PubMed 16768798). A double mqsR-mqsA deletion leads to increased rpoS mRNA levels, resulting in increased cyclic-di-GMP levels, increasing stress resistance, increased biofilm formation (PubMed 21516113). The double mutant has increased metabolism and respiration in the presence of the bile acid deoxycholate and consequently grows less well. Decreases cell survival in the presence of 20% deoxycholate (PubMed 25534751). {ECO 0000269|PubMed 16768798, ECO 0000269|PubMed 21516113, ECO 0000269|PubMed 25534751}. # DOMAIN MQSA_ECOLI The Zn-binding N-terminal domain (residues 1-65) binds to the MqsR mRNA interferase toxin and makes contact with the DNA phosphate backbone, while the C-terminus (residues 70-131) binds the promoter in a sequence-specific manner. They are linked by a short flexible domain (PubMed 22789559). {ECO 0000269|PubMed 20041169, ECO 0000269|PubMed 21068382, ECO 0000269|PubMed 22789559}. # EcoGene EG13022 mqsA # FUNCTION MQSA_ECOLI Antitoxin component of a type II toxin-antitoxin (TA) module. Labile antitoxin that binds to the MqsR mRNA interferase toxin and neutralizes its endoribonuclease activity. Overexpression prevents MqsR-mediated cessation of cell growth and inhibition of cell proliferation. Initially reported to act as a cotranscription factor with MqsA (PubMed 19690171, PubMed 20105222). Following further experiments, the MqsR-MqsA complex does not bind DNA and all reported data are actually due to a small fraction of free MqsA alone binding DNA. Addition of MqsR to a preformed MqsA-promoter DNA complex causes dissociation of the MqsA-DNA complex, probably causing derepression of MqsA- repressed transcripts (PubMed 23172222). MqsA binds to 2 palindromes in the promoter region of the mqsRA operon activating its transcription. Binds to other promoters, inducing mcbR and spy and repressing cspD among others (PubMed 20105222). Binds to and represses the rpoS promoter, the master stress regulator, resulting in decreased cyclic-di-GMP, reduced stress resistance, increased cell motility and decreased biofilm formation; in these experiments 5 TA modules are missing (lacks MazEF, RelEB, ChpB, YoeB-YefM, YafQ-DinJ) (PubMed 21516113). An earlier study showed overexpression alone increases biofilm formation, perhaps by repressing cspD; in these experiments the 5 TA modules are present (PubMed 20105222). Represses the csgD promoter. In the presence of stress, when this protein is degraded, the promoters it represses are derepressed, leading to biofilm formation (Probable). This TA system mediates cell growth during bile acid deoxycholate stress by degrading mRNA for probable deoxycholate-binding protein YgiS; bile acid detergents such as deoxycholate are important for host defense against bacterial growth in the gall bladder and duodenum (PubMed 25534751). {ECO 0000269|PubMed 19690171, ECO 0000269|PubMed 19943910, ECO 0000269|PubMed 20105222, ECO 0000269|PubMed 21516113, ECO 0000269|PubMed 23172222, ECO 0000269|PubMed 25534751, ECO 0000303|PubMed 24212724}. # GO_function GO:0043565 sequence-specific DNA binding; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IMP:EcoCyc. # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.260.40 -; 1. # INDUCTION MQSA_ECOLI Induced by amino acid starvation, glucose starvation and when translation is blocked. Induction is decreased in the absence of the Lon protease suggesting, by homology to other toxin-antitoxin systems, that Lon may degrade the MqsA antitoxin. Transcription is activated by MqsA (PubMed 20105222). It has been suggested that MqsA represses its own operon (PubMed 19690171). Not more induced in persister cells (PubMed 16768798). A member of the mqsRA operon. This operon induced by ectopic expression of toxins RelE, HicA and YafQ but not by MazF or HicA (PubMed 23432955). {ECO 0000269|PubMed 16768798, ECO 0000269|PubMed 19943910, ECO 0000269|PubMed 20105222, ECO 0000269|PubMed 23432955, ECO 0000303|PubMed 19690171}. # INTERACTION MQSA_ECOLI P69222 infA; NbExp=2; IntAct=EBI-1120353, EBI-1120746; P07000 pldB; NbExp=2; IntAct=EBI-1120353, EBI-9134416; P0ACQ0 rbsR; NbExp=3; IntAct=EBI-1120353, EBI-1119646; P0A7L8 rpmA; NbExp=2; IntAct=EBI-1120353, EBI-546875; P0AGB6 rpoE; NbExp=2; IntAct=EBI-1120353, EBI-1129580; P0AAU7 ybfE; NbExp=2; IntAct=EBI-1120353, EBI-9138393; # IntAct Q46864 54 # InterPro IPR001387 Cro/C1-type_HTH # InterPro IPR010982 Lambda_DNA-bd_dom # InterPro IPR022452 MqsA # InterPro IPR022453 Znf_MqsA-type # InterPro IPR032758 MqsA/HigA-2 # KEGG_Brite ko03000 Transcription factors # Organism MQSA_ECOLI Escherichia coli (strain K12) # PATRIC 32121456 VBIEscCol129921_3115 # PDB 2KZ8 NMR; -; A=1-131 # PDB 3FMY X-ray; 1.40 A; A=62-131 # PDB 3GA8 X-ray; 1.70 A; A=1-76 # PDB 3GN5 X-ray; 2.15 A; A/B=1-131 # PDB 3HI2 X-ray; 2.00 A; A/C=1-76 # PDB 3O9X X-ray; 2.10 A; A/B=1-131 # PIR C65089 C65089 # PROSITE PS50943 HTH_CROC1 # PTM MQSA_ECOLI Degraded in the presence of oxidative stress, maybe by the Lon and/or ClpX proteases. {ECO 0000303|PubMed 20105222, ECO 0000303|PubMed 21516113}. # Pfam PF15731 MqsA_antitoxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Antitoxin MqsA {ECO:0000303|PubMed 20041169} # RefSeq NP_417493 NC_000913.3 # RefSeq WP_000650107 NZ_LN832404.1 # SIMILARITY Contains 1 HTH cro/C1-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00257}. # SMART SM00530 HTH_XRE # SUBUNIT MQSA_ECOLI Homodimer. Crystallizes as a heterotetramer with MqsA, MqsR-MqsA(2)-MqsR (PubMed 20041169). Purifies as a probable heterohexamer of 2 MqsR dimers and 1 MqsA dimer (PubMed 19690171). Binds promoter DNA as a dimer (PubMed 21068382). When the 2 dissociate the MsqR mRNA interferase becomes active. {ECO 0000269|PubMed 19690171, ECO 0000269|PubMed 20041169, ECO 0000269|PubMed 20823526, ECO 0000269|PubMed 21068382}. # SUPFAM SSF47413 SSF47413 # TIGRFAMs TIGR03830 CxxCG_CxxCG_HTH # TIGRFAMs TIGR03831 YgiT_finger # eggNOG COG1396 LUCA # eggNOG ENOG4105WJ3 Bacteria BLAST swissprot:MQSA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MQSA_ECOLI BioCyc ECOL316407:JW2989-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2989-MONOMER BioCyc EcoCyc:G7571-MONOMER http://biocyc.org/getid?id=EcoCyc:G7571-MONOMER BioCyc MetaCyc:G7571-MONOMER http://biocyc.org/getid?id=MetaCyc:G7571-MONOMER COG COG1396 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1396 DIP DIP-12226N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12226N DOI 10.1016/j.bbapap.2012.06.016 http://dx.doi.org/10.1016/j.bbapap.2012.06.016 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nchembio.560 http://dx.doi.org/10.1038/nchembio.560 DOI 10.1038/srep03186 http://dx.doi.org/10.1038/srep03186 DOI 10.1074/jbc.M109.032904 http://dx.doi.org/10.1074/jbc.M109.032904 DOI 10.1074/jbc.M110.172643 http://dx.doi.org/10.1074/jbc.M110.172643 DOI 10.1074/jbc.M112.421008 http://dx.doi.org/10.1074/jbc.M112.421008 DOI 10.1107/S1744309110028617 http://dx.doi.org/10.1107/S1744309110028617 DOI 10.1111/1462-2920.12749 http://dx.doi.org/10.1111/1462-2920.12749 DOI 10.1111/j.1365-2958.2009.06969.x http://dx.doi.org/10.1111/j.1365-2958.2009.06969.x DOI 10.1111/j.1462-2920.2009.02147.x http://dx.doi.org/10.1111/j.1462-2920.2009.02147.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1186/1471-2180-13-45 http://dx.doi.org/10.1186/1471-2180-13-45 DOI 10.1186/1471-2180-6-53 http://dx.doi.org/10.1186/1471-2180-6-53 DOI 10.1371/journal.ppat.1000706 http://dx.doi.org/10.1371/journal.ppat.1000706 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2840 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2840 EcoGene EG13022 http://www.ecogene.org/geneInfo.php?eg_id=EG13022 EnsemblBacteria AAC76057 http://www.ensemblgenomes.org/id/AAC76057 EnsemblBacteria AAC76057 http://www.ensemblgenomes.org/id/AAC76057 EnsemblBacteria BAE77077 http://www.ensemblgenomes.org/id/BAE77077 EnsemblBacteria BAE77077 http://www.ensemblgenomes.org/id/BAE77077 EnsemblBacteria BAE77077 http://www.ensemblgenomes.org/id/BAE77077 EnsemblBacteria b3021 http://www.ensemblgenomes.org/id/b3021 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.260.40 http://www.cathdb.info/version/latest/superfamily/1.10.260.40 GeneID 945814 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945814 HOGENOM HOG000151625 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000151625&db=HOGENOM6 IntAct Q46864 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46864* InterPro IPR001387 http://www.ebi.ac.uk/interpro/entry/IPR001387 InterPro IPR010982 http://www.ebi.ac.uk/interpro/entry/IPR010982 InterPro IPR022452 http://www.ebi.ac.uk/interpro/entry/IPR022452 InterPro IPR022453 http://www.ebi.ac.uk/interpro/entry/IPR022453 InterPro IPR032758 http://www.ebi.ac.uk/interpro/entry/IPR032758 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW2989 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2989 KEGG_Gene eco:b3021 http://www.genome.jp/dbget-bin/www_bget?eco:b3021 KEGG_Orthology KO:K13655 http://www.genome.jp/dbget-bin/www_bget?KO:K13655 OMA CGEGIWD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CGEGIWD PDB 2KZ8 http://www.ebi.ac.uk/pdbe-srv/view/entry/2KZ8 PDB 3FMY http://www.ebi.ac.uk/pdbe-srv/view/entry/3FMY PDB 3GA8 http://www.ebi.ac.uk/pdbe-srv/view/entry/3GA8 PDB 3GN5 http://www.ebi.ac.uk/pdbe-srv/view/entry/3GN5 PDB 3HI2 http://www.ebi.ac.uk/pdbe-srv/view/entry/3HI2 PDB 3O9X http://www.ebi.ac.uk/pdbe-srv/view/entry/3O9X PDBsum 2KZ8 http://www.ebi.ac.uk/pdbsum/2KZ8 PDBsum 3FMY http://www.ebi.ac.uk/pdbsum/3FMY PDBsum 3GA8 http://www.ebi.ac.uk/pdbsum/3GA8 PDBsum 3GN5 http://www.ebi.ac.uk/pdbsum/3GN5 PDBsum 3HI2 http://www.ebi.ac.uk/pdbsum/3HI2 PDBsum 3O9X http://www.ebi.ac.uk/pdbsum/3O9X PROSITE PS50943 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50943 PSORT swissprot:MQSA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MQSA_ECOLI PSORT-B swissprot:MQSA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MQSA_ECOLI PSORT2 swissprot:MQSA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MQSA_ECOLI Pfam PF15731 http://pfam.xfam.org/family/PF15731 Phobius swissprot:MQSA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MQSA_ECOLI ProteinModelPortal Q46864 http://www.proteinmodelportal.org/query/uniprot/Q46864 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16768798 http://www.ncbi.nlm.nih.gov/pubmed/16768798 PubMed 19690171 http://www.ncbi.nlm.nih.gov/pubmed/19690171 PubMed 19943910 http://www.ncbi.nlm.nih.gov/pubmed/19943910 PubMed 20041169 http://www.ncbi.nlm.nih.gov/pubmed/20041169 PubMed 20105222 http://www.ncbi.nlm.nih.gov/pubmed/20105222 PubMed 20823526 http://www.ncbi.nlm.nih.gov/pubmed/20823526 PubMed 21068382 http://www.ncbi.nlm.nih.gov/pubmed/21068382 PubMed 21516113 http://www.ncbi.nlm.nih.gov/pubmed/21516113 PubMed 22789559 http://www.ncbi.nlm.nih.gov/pubmed/22789559 PubMed 23172222 http://www.ncbi.nlm.nih.gov/pubmed/23172222 PubMed 23432955 http://www.ncbi.nlm.nih.gov/pubmed/23432955 PubMed 24212724 http://www.ncbi.nlm.nih.gov/pubmed/24212724 PubMed 25534751 http://www.ncbi.nlm.nih.gov/pubmed/25534751 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417493 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417493 RefSeq WP_000650107 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000650107 SMART SM00530 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00530 SMR Q46864 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46864 STRING 511145.b3021 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3021&targetmode=cogs STRING COG1396 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1396&targetmode=cogs SUPFAM SSF47413 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47413 TIGRFAMs TIGR03830 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03830 TIGRFAMs TIGR03831 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03831 UniProtKB MQSA_ECOLI http://www.uniprot.org/uniprot/MQSA_ECOLI UniProtKB-AC Q46864 http://www.uniprot.org/uniprot/Q46864 charge swissprot:MQSA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MQSA_ECOLI eggNOG COG1396 http://eggnogapi.embl.de/nog_data/html/tree/COG1396 eggNOG ENOG4105WJ3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105WJ3 epestfind swissprot:MQSA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MQSA_ECOLI garnier swissprot:MQSA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MQSA_ECOLI helixturnhelix swissprot:MQSA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MQSA_ECOLI hmoment swissprot:MQSA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MQSA_ECOLI iep swissprot:MQSA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MQSA_ECOLI inforesidue swissprot:MQSA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MQSA_ECOLI octanol swissprot:MQSA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MQSA_ECOLI pepcoil swissprot:MQSA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MQSA_ECOLI pepdigest swissprot:MQSA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MQSA_ECOLI pepinfo swissprot:MQSA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MQSA_ECOLI pepnet swissprot:MQSA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MQSA_ECOLI pepstats swissprot:MQSA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MQSA_ECOLI pepwheel swissprot:MQSA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MQSA_ECOLI pepwindow swissprot:MQSA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MQSA_ECOLI sigcleave swissprot:MQSA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MQSA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261763 6 # CDD cd00383 trans_reg_C # EcoGene EG13190 rstA # FUNCTION RSTA_ECOLI Member of the two-component regulatory system RstB/RstA. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0000160 phosphorelay signal transduction system; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # INDUCTION Induced by low extracellular levels of magnesium via the PhoQ/PhoP two-component regulatory system. {ECO:0000269|PubMed 12813061}. # INTERACTION RSTA_ECOLI P21866 kdpE; NbExp=2; IntAct=EBI-558990, EBI-6403634; # IntAct P52108 12 # InterPro IPR001789 Sig_transdc_resp-reg_receiver # InterPro IPR001867 OmpR/PhoB-type_DNA-bd # InterPro IPR011006 CheY-like_superfamily # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR016032 Sig_transdc_resp-reg_C-effctor # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02022 M00446 RstB-RstA two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # Organism RSTA_ECOLI Escherichia coli (strain K12) # PATRIC 32118518 VBIEscCol129921_1679 # PIR B64917 B64917 # PROSITE PS50110 RESPONSE_REGULATORY # PROSITE PS51755 OMPR_PHOB # PTM RSTA_ECOLI Phosphorylated by RstB. {ECO 0000269|PubMed 15522865}. # Pfam PF00072 Response_reg # Pfam PF00486 Trans_reg_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RSTA_ECOLI Transcriptional regulatory protein RstA # RefSeq NP_416125 NC_000913.3 # RefSeq WP_001092508 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA82081.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA15346.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Contains 1 OmpR/PhoB-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU01091}. # SIMILARITY Contains 1 response regulatory domain. {ECO:0000255|PROSITE-ProRule PRU00169}. # SMART SM00448 REC # SMART SM00862 Trans_reg_C # SUBCELLULAR LOCATION RSTA_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF46894 SSF46894 # SUPFAM SSF52172 SSF52172 # eggNOG COG0745 LUCA # eggNOG ENOG4107EXC Bacteria BLAST swissprot:RSTA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RSTA_ECOLI BioCyc ECOL316407:JW1600-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1600-MONOMER BioCyc EcoCyc:RSTA-MONOMER http://biocyc.org/getid?id=EcoCyc:RSTA-MONOMER COG COG0745 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0745 DIP DIP-10807N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10807N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M410104200 http://dx.doi.org/10.1074/jbc.M410104200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1111/j.1365-2958.1992.tb00890.x http://dx.doi.org/10.1111/j.1365-2958.1992.tb00890.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.185.13.3696-3702.2003 http://dx.doi.org/10.1128/JB.185.13.3696-3702.2003 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U41101 http://www.ebi.ac.uk/ena/data/view/U41101 EchoBASE EB2982 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2982 EcoGene EG13190 http://www.ecogene.org/geneInfo.php?eg_id=EG13190 EnsemblBacteria AAC74680 http://www.ensemblgenomes.org/id/AAC74680 EnsemblBacteria AAC74680 http://www.ensemblgenomes.org/id/AAC74680 EnsemblBacteria BAA15346 http://www.ensemblgenomes.org/id/BAA15346 EnsemblBacteria BAA15346 http://www.ensemblgenomes.org/id/BAA15346 EnsemblBacteria BAA15346 http://www.ensemblgenomes.org/id/BAA15346 EnsemblBacteria b1608 http://www.ensemblgenomes.org/id/b1608 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 946199 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946199 HOGENOM HOG000034819 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000034819&db=HOGENOM6 InParanoid P52108 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P52108 IntAct P52108 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P52108* InterPro IPR001789 http://www.ebi.ac.uk/interpro/entry/IPR001789 InterPro IPR001867 http://www.ebi.ac.uk/interpro/entry/IPR001867 InterPro IPR011006 http://www.ebi.ac.uk/interpro/entry/IPR011006 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR016032 http://www.ebi.ac.uk/interpro/entry/IPR016032 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW1600 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1600 KEGG_Gene eco:b1608 http://www.genome.jp/dbget-bin/www_bget?eco:b1608 KEGG_Orthology KO:K07661 http://www.genome.jp/dbget-bin/www_bget?KO:K07661 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 MINT MINT-1274913 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1274913 OMA PMSFRIL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PMSFRIL PROSITE PS50110 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50110 PROSITE PS51755 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51755 PSORT swissprot:RSTA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RSTA_ECOLI PSORT-B swissprot:RSTA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RSTA_ECOLI PSORT2 swissprot:RSTA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RSTA_ECOLI Pfam PF00072 http://pfam.xfam.org/family/PF00072 Pfam PF00486 http://pfam.xfam.org/family/PF00486 Phobius swissprot:RSTA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RSTA_ECOLI PhylomeDB P52108 http://phylomedb.org/?seqid=P52108 ProteinModelPortal P52108 http://www.proteinmodelportal.org/query/uniprot/P52108 PubMed 12813061 http://www.ncbi.nlm.nih.gov/pubmed/12813061 PubMed 1495392 http://www.ncbi.nlm.nih.gov/pubmed/1495392 PubMed 15522865 http://www.ncbi.nlm.nih.gov/pubmed/15522865 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416125 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416125 RefSeq WP_001092508 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001092508 SMART SM00448 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00448 SMART SM00862 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00862 SMR P52108 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P52108 STRING 511145.b1608 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1608&targetmode=cogs STRING COG0745 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0745&targetmode=cogs SUPFAM SSF46894 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46894 SUPFAM SSF52172 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52172 UniProtKB RSTA_ECOLI http://www.uniprot.org/uniprot/RSTA_ECOLI UniProtKB-AC P52108 http://www.uniprot.org/uniprot/P52108 charge swissprot:RSTA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RSTA_ECOLI eggNOG COG0745 http://eggnogapi.embl.de/nog_data/html/tree/COG0745 eggNOG ENOG4107EXC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107EXC epestfind swissprot:RSTA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RSTA_ECOLI garnier swissprot:RSTA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RSTA_ECOLI helixturnhelix swissprot:RSTA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RSTA_ECOLI hmoment swissprot:RSTA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RSTA_ECOLI iep swissprot:RSTA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RSTA_ECOLI inforesidue swissprot:RSTA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RSTA_ECOLI octanol swissprot:RSTA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RSTA_ECOLI pepcoil swissprot:RSTA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RSTA_ECOLI pepdigest swissprot:RSTA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RSTA_ECOLI pepinfo swissprot:RSTA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RSTA_ECOLI pepnet swissprot:RSTA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RSTA_ECOLI pepstats swissprot:RSTA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RSTA_ECOLI pepwheel swissprot:RSTA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RSTA_ECOLI pepwindow swissprot:RSTA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RSTA_ECOLI sigcleave swissprot:RSTA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RSTA_ECOLI ## Database ID URL or Descriptions # BioGrid 4263518 285 # CAUTION Was originally thought to be WecF, the 4-alpha-L- fucosyltransferase. {ECO:0000305|PubMed 11673418}. # EcoGene EG11457 wzyE # FUNCTION WZYE_ECOLI Probably involved in the polymerization of enterobacterial common antigen (ECA) trisaccharide repeat units. Required for the assembly of the phosphoglyceride-linked form of ECA (ECA(PG)) and the water-soluble cyclic form of ECA (ECA(CYC)). {ECO 0000269|PubMed 16199561}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IEA:UniProtKB-HAMAP. # GO_process GO:0009246 enterobacterial common antigen biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # HAMAP MF_01003 WzyE # InterPro IPR010691 WzyE # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01003 Glycosyltransferases # Organism WZYE_ECOLI Escherichia coli (strain K12) # PATHWAY WZYE_ECOLI Bacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis. {ECO 0000255|HAMAP-Rule MF_01003, ECO 0000269|PubMed 16199561}. # PATRIC 32123081 VBIEscCol129921_3910 # PIR F65183 F65183 # PIR S30687 S30687 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Probable ECA polymerase {ECO:0000255|HAMAP-Rule MF_01003, ECO:0000305} # RefSeq NP_418241 NC_000913.3 # RefSeq WP_000055129 NZ_LN832404.1 # SIMILARITY Belongs to the WzyE family. {ECO:0000255|HAMAP- Rule MF_01003, ECO:0000305}. # SUBCELLULAR LOCATION WZYE_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01003, ECO 0000305}; Multi-pass membrane protein {ECO 0000255|HAMAP-Rule MF_01003}. # SUBUNIT WZYE_ECOLI Probably part of a complex composed of WzxE, WzyE and WzzE. {ECO 0000255|HAMAP-Rule MF_01003, ECO 0000305|PubMed 16816184}. # eggNOG ENOG4105DAD Bacteria # eggNOG ENOG410XT3V LUCA BLAST swissprot:WZYE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:WZYE_ECOLI BioCyc ECOL316407:JW3769-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3769-MONOMER BioCyc EcoCyc:FUC4NACTRANS-MONOMER http://biocyc.org/getid?id=EcoCyc:FUC4NACTRANS-MONOMER BioCyc MetaCyc:FUC4NACTRANS-MONOMER http://biocyc.org/getid?id=MetaCyc:FUC4NACTRANS-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00461-06 http://dx.doi.org/10.1128/JB.00461-06 DOI 10.1128/JB.183.22.6509-6516.2001 http://dx.doi.org/10.1128/JB.183.22.6509-6516.2001 DOI 10.1128/JB.187.20.6917-6927.2005 http://dx.doi.org/10.1128/JB.187.20.6917-6927.2005 EMBL AF375882 http://www.ebi.ac.uk/ena/data/view/AF375882 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1426 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1426 EcoGene EG11457 http://www.ecogene.org/geneInfo.php?eg_id=EG11457 EnsemblBacteria AAC76800 http://www.ensemblgenomes.org/id/AAC76800 EnsemblBacteria AAC76800 http://www.ensemblgenomes.org/id/AAC76800 EnsemblBacteria BAE77504 http://www.ensemblgenomes.org/id/BAE77504 EnsemblBacteria BAE77504 http://www.ensemblgenomes.org/id/BAE77504 EnsemblBacteria BAE77504 http://www.ensemblgenomes.org/id/BAE77504 EnsemblBacteria b3793 http://www.ensemblgenomes.org/id/b3793 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_process GO:0009246 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009246 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 948293 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948293 HAMAP MF_01003 http://hamap.expasy.org/unirule/MF_01003 HOGENOM HOG000219137 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219137&db=HOGENOM6 InterPro IPR010691 http://www.ebi.ac.uk/interpro/entry/IPR010691 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01003 http://www.genome.jp/dbget-bin/www_bget?ko01003 KEGG_Gene ecj:JW3769 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3769 KEGG_Gene eco:b3793 http://www.genome.jp/dbget-bin/www_bget?eco:b3793 KEGG_Orthology KO:K02853 http://www.genome.jp/dbget-bin/www_bget?KO:K02853 OMA WLWPDRP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WLWPDRP PSORT swissprot:WZYE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:WZYE_ECOLI PSORT-B swissprot:WZYE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:WZYE_ECOLI PSORT2 swissprot:WZYE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:WZYE_ECOLI Phobius swissprot:WZYE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:WZYE_ECOLI ProteinModelPortal P27835 http://www.proteinmodelportal.org/query/uniprot/P27835 PubMed 11673418 http://www.ncbi.nlm.nih.gov/pubmed/11673418 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16199561 http://www.ncbi.nlm.nih.gov/pubmed/16199561 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16816184 http://www.ncbi.nlm.nih.gov/pubmed/16816184 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418241 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418241 RefSeq WP_000055129 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000055129 STRING 511145.b3793 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3793&targetmode=cogs UniProtKB WZYE_ECOLI http://www.uniprot.org/uniprot/WZYE_ECOLI UniProtKB-AC P27835 http://www.uniprot.org/uniprot/P27835 charge swissprot:WZYE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:WZYE_ECOLI eggNOG ENOG4105DAD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DAD eggNOG ENOG410XT3V http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XT3V epestfind swissprot:WZYE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:WZYE_ECOLI garnier swissprot:WZYE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:WZYE_ECOLI helixturnhelix swissprot:WZYE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:WZYE_ECOLI hmoment swissprot:WZYE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:WZYE_ECOLI iep swissprot:WZYE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:WZYE_ECOLI inforesidue swissprot:WZYE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:WZYE_ECOLI octanol swissprot:WZYE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:WZYE_ECOLI pepcoil swissprot:WZYE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:WZYE_ECOLI pepdigest swissprot:WZYE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:WZYE_ECOLI pepinfo swissprot:WZYE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:WZYE_ECOLI pepnet swissprot:WZYE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:WZYE_ECOLI pepstats swissprot:WZYE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:WZYE_ECOLI pepwheel swissprot:WZYE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:WZYE_ECOLI pepwindow swissprot:WZYE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:WZYE_ECOLI sigcleave swissprot:WZYE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:WZYE_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES MNME_ECOLI Kinetic parameters KM=511 uM for GTP {ECO 0000269|PubMed 12730230, ECO 0000269|PubMed 17143896}; KM=346 uM for XTP {ECO 0000269|PubMed 12730230, ECO 0000269|PubMed 17143896}; Vmax=193 nmol/min/mg enzyme with GTP as substrate {ECO 0000269|PubMed 12730230, ECO 0000269|PubMed 17143896}; Vmax=100 nmol/min/mg enzyme with XTP as substrate {ECO 0000269|PubMed 12730230, ECO 0000269|PubMed 17143896}; pH dependence Optimum pH is 7.5-9.5. {ECO 0000269|PubMed 12730230, ECO 0000269|PubMed 17143896}; # BioGrid 4261522 119 # CDD cd04164 trmE # COFACTOR Name=K(+); Xref=ChEBI:CHEBI 29103; Note=Binds 1 potassium ion per subunit.; # ENZYME REGULATION MNME_ECOLI GTPase activity is strongly activated by potassium ions. # EcoGene EG10997 mnmE # FUNCTION MNME_ECOLI Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34. # GO_component GO:0005737 cytoplasm; IDA:EcoCyc. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_function GO:0003924 GTPase activity; IDA:EcoCyc. # GO_function GO:0005525 GTP binding; IDA:EcoCyc. # GO_function GO:0019003 GDP binding; IDA:EcoCyc. # GO_function GO:0030955 potassium ion binding; IDA:EcoCyc. # GO_process GO:0002098 tRNA wobble uridine modification; IDA:EcoCyc. # GO_process GO:0006805 xenobiotic metabolic process; IMP:EcoCyc. # GO_process GO:0009268 response to pH; IMP:EcoCyc. # GO_process GO:0030488 tRNA methylation; IMP:EcoCyc. # GO_process GO:0061077 chaperone-mediated protein folding; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003924 GTPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0006457 protein folding # GOslim_process GO:0008150 biological_process # Gene3D 1.20.120.430 -; 3. # Gene3D 3.30.1360.120 -; 1. # Gene3D 3.40.50.300 -; 2. # HAMAP MF_00379 GTPase_MnmE # INTERACTION MNME_ECOLI P0A6U3 mnmG; NbExp=4; IntAct=EBI-550986, EBI-550977; P69432 pgaD; NbExp=3; IntAct=EBI-550986, EBI-562069; # IntAct P25522 23 # InterPro IPR004520 GTPase_MnmE # InterPro IPR005225 Small_GTP-bd_dom # InterPro IPR006073 GTP_binding_domain # InterPro IPR018948 GTP-bd_TrmE_N # InterPro IPR025867 MnmE_helical # InterPro IPR027266 TrmE/GcvT_dom1 # InterPro IPR027368 MnmE_dom2 # InterPro IPR027417 P-loop_NTPase # InterPro IPR031168 G_TrmE # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # Organism MNME_ECOLI Escherichia coli (strain K12) # PATRIC 32122909 VBIEscCol129921_3830 # PDB 1RFL NMR; -; A=210-377 # PDB 2GJ8 X-ray; 1.70 A; A/B/C/D=216-384 # PDB 2GJ9 X-ray; 2.00 A; A/B/C/D=216-384 # PDB 2GJA X-ray; 1.85 A; A/B=216-384 # PIR A38160 A38160 # PIR C65173 C65173 # PROSITE PS51709 G_TRME # Pfam PF01926 MMR_HSR1 # Pfam PF10396 TrmE_N # Pfam PF12631 MnmE_helical # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName tRNA modification GTPase MnmE {ECO:0000255|HAMAP-Rule MF_00379} # RefSeq NP_418162 NC_000913.3 # RefSeq WP_001282346 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB19981.1; Type=Miscellaneous discrepancy; Evidence={ECO 0000305}; # SIMILARITY Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. TrmE GTPase family. {ECO:0000255|HAMAP- Rule MF_00379}. # SIMILARITY Contains 1 TrmE-type G (guanine nucleotide-binding) domain. {ECO 0000305}. # SUBCELLULAR LOCATION MNME_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00379, ECO 0000269|PubMed 10601028}. Note=Partially associated with the inner membrane. # SUBUNIT MNME_ECOLI Homodimer. Heterotetramer of two MnmE and two MnmG subunits. {ECO 0000255|HAMAP-Rule MF_00379, ECO 0000269|PubMed 16763562}. # SUPFAM SSF52540 SSF52540; 2 # TIGRFAMs TIGR00231 small_GTP # TIGRFAMs TIGR00450 mnmE_trmE_thdF # eggNOG COG0486 LUCA # eggNOG ENOG4105C1H Bacteria BLAST swissprot:MNME_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MNME_ECOLI BioCyc ECOL316407:JW3684-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3684-MONOMER BioCyc EcoCyc:EG10997-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10997-MONOMER BioCyc MetaCyc:EG10997-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10997-MONOMER COG COG0486 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0486 DIP DIP-11033N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11033N DOI 10.1002/prot.21186 http://dx.doi.org/10.1002/prot.21186 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/sj.emboj.7601171 http://dx.doi.org/10.1038/sj.emboj.7601171 DOI 10.1074/jbc.M301381200 http://dx.doi.org/10.1074/jbc.M301381200 DOI 10.1074/jbc.M503223200 http://dx.doi.org/10.1074/jbc.M503223200 DOI 10.1093/emboj/18.24.7063 http://dx.doi.org/10.1093/emboj/18.24.7063 DOI 10.1093/nar/gkl752 http://dx.doi.org/10.1093/nar/gkl752 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.-.- {ECO:0000255|HAMAP-Rule:MF_00379} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.-.- {ECO:0000255|HAMAP-Rule:MF_00379} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL S57109 http://www.ebi.ac.uk/ena/data/view/S57109 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.6.-.- {ECO:0000255|HAMAP-Rule:MF_00379} http://enzyme.expasy.org/EC/3.6.-.- {ECO:0000255|HAMAP-Rule:MF_00379} EchoBASE EB0990 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0990 EcoGene EG10997 http://www.ecogene.org/geneInfo.php?eg_id=EG10997 EnsemblBacteria AAC76729 http://www.ensemblgenomes.org/id/AAC76729 EnsemblBacteria AAC76729 http://www.ensemblgenomes.org/id/AAC76729 EnsemblBacteria BAE77587 http://www.ensemblgenomes.org/id/BAE77587 EnsemblBacteria BAE77587 http://www.ensemblgenomes.org/id/BAE77587 EnsemblBacteria BAE77587 http://www.ensemblgenomes.org/id/BAE77587 EnsemblBacteria b3706 http://www.ensemblgenomes.org/id/b3706 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_function GO:0019003 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019003 GO_function GO:0030955 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030955 GO_process GO:0002098 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002098 GO_process GO:0006805 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006805 GO_process GO:0009268 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009268 GO_process GO:0030488 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030488 GO_process GO:0061077 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061077 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.20.120.430 http://www.cathdb.info/version/latest/superfamily/1.20.120.430 Gene3D 3.30.1360.120 http://www.cathdb.info/version/latest/superfamily/3.30.1360.120 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948222 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948222 HAMAP MF_00379 http://hamap.expasy.org/unirule/MF_00379 HOGENOM HOG000200714 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000200714&db=HOGENOM6 InParanoid P25522 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P25522 IntAct P25522 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P25522* IntEnz 3.6.-.- {ECO:0000255|HAMAP-Rule:MF_00379} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.-.- {ECO:0000255|HAMAP-Rule:MF_00379} InterPro IPR004520 http://www.ebi.ac.uk/interpro/entry/IPR004520 InterPro IPR005225 http://www.ebi.ac.uk/interpro/entry/IPR005225 InterPro IPR006073 http://www.ebi.ac.uk/interpro/entry/IPR006073 InterPro IPR018948 http://www.ebi.ac.uk/interpro/entry/IPR018948 InterPro IPR025867 http://www.ebi.ac.uk/interpro/entry/IPR025867 InterPro IPR027266 http://www.ebi.ac.uk/interpro/entry/IPR027266 InterPro IPR027368 http://www.ebi.ac.uk/interpro/entry/IPR027368 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR031168 http://www.ebi.ac.uk/interpro/entry/IPR031168 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW3684 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3684 KEGG_Gene eco:b3706 http://www.genome.jp/dbget-bin/www_bget?eco:b3706 KEGG_Orthology KO:K03650 http://www.genome.jp/dbget-bin/www_bget?KO:K03650 OMA FTPRYAY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FTPRYAY PDB 1RFL http://www.ebi.ac.uk/pdbe-srv/view/entry/1RFL PDB 2GJ8 http://www.ebi.ac.uk/pdbe-srv/view/entry/2GJ8 PDB 2GJ9 http://www.ebi.ac.uk/pdbe-srv/view/entry/2GJ9 PDB 2GJA http://www.ebi.ac.uk/pdbe-srv/view/entry/2GJA PDBsum 1RFL http://www.ebi.ac.uk/pdbsum/1RFL PDBsum 2GJ8 http://www.ebi.ac.uk/pdbsum/2GJ8 PDBsum 2GJ9 http://www.ebi.ac.uk/pdbsum/2GJ9 PDBsum 2GJA http://www.ebi.ac.uk/pdbsum/2GJA PROSITE PS51709 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51709 PSORT swissprot:MNME_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MNME_ECOLI PSORT-B swissprot:MNME_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MNME_ECOLI PSORT2 swissprot:MNME_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MNME_ECOLI Pfam PF01926 http://pfam.xfam.org/family/PF01926 Pfam PF10396 http://pfam.xfam.org/family/PF10396 Pfam PF12631 http://pfam.xfam.org/family/PF12631 Phobius swissprot:MNME_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MNME_ECOLI PhylomeDB P25522 http://phylomedb.org/?seqid=P25522 ProteinModelPortal P25522 http://www.proteinmodelportal.org/query/uniprot/P25522 PubMed 10601028 http://www.ncbi.nlm.nih.gov/pubmed/10601028 PubMed 12730230 http://www.ncbi.nlm.nih.gov/pubmed/12730230 PubMed 15983041 http://www.ncbi.nlm.nih.gov/pubmed/15983041 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16763562 http://www.ncbi.nlm.nih.gov/pubmed/16763562 PubMed 17062623 http://www.ncbi.nlm.nih.gov/pubmed/17062623 PubMed 17143896 http://www.ncbi.nlm.nih.gov/pubmed/17143896 PubMed 1917835 http://www.ncbi.nlm.nih.gov/pubmed/1917835 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418162 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418162 RefSeq WP_001282346 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001282346 SMR P25522 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P25522 STRING 511145.b3706 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3706&targetmode=cogs STRING COG0486 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0486&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR00231 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00231 TIGRFAMs TIGR00450 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00450 UniProtKB MNME_ECOLI http://www.uniprot.org/uniprot/MNME_ECOLI UniProtKB-AC P25522 http://www.uniprot.org/uniprot/P25522 charge swissprot:MNME_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MNME_ECOLI eggNOG COG0486 http://eggnogapi.embl.de/nog_data/html/tree/COG0486 eggNOG ENOG4105C1H http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C1H epestfind swissprot:MNME_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MNME_ECOLI garnier swissprot:MNME_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MNME_ECOLI helixturnhelix swissprot:MNME_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MNME_ECOLI hmoment swissprot:MNME_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MNME_ECOLI iep swissprot:MNME_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MNME_ECOLI inforesidue swissprot:MNME_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MNME_ECOLI octanol swissprot:MNME_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MNME_ECOLI pepcoil swissprot:MNME_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MNME_ECOLI pepdigest swissprot:MNME_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MNME_ECOLI pepinfo swissprot:MNME_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MNME_ECOLI pepnet swissprot:MNME_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MNME_ECOLI pepstats swissprot:MNME_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MNME_ECOLI pepwheel swissprot:MNME_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MNME_ECOLI pepwindow swissprot:MNME_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MNME_ECOLI sigcleave swissprot:MNME_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MNME_ECOLI ## Database ID URL or Descriptions # BioGrid 4260552 15 # EcoGene EG14411 torI # FUNCTION TORI_ECOLI Transcription inhibitory protein for the torCAD operon. Also acts as an excisionase and plays an essential role in the defective prophage CPS53 excision. {ECO 0000269|PubMed 15197250, ECO 0000269|PubMed 16079126}. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0043565 sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0006310 DNA recombination; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0044349 DNA excision; IMP:EcoCyc. # GO_process GO:2000143 negative regulation of DNA-templated transcription, initiation; IDA:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # INTERACTION TORI_ECOLI P76502 sixA; NbExp=3; IntAct=EBI-9154838, EBI-548621; # Organism TORI_ECOLI Escherichia coli (strain K12) # PATRIC 32120105 VBIEscCol129921_2461 # PDB 1Z4H NMR; -; A=1-66 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TORI_ECOLI Response regulator inhibitor for tor operon # RefSeq WP_001163428 NZ_LN832404.1 # RefSeq YP_588463 NC_000913.3 # SIMILARITY Belongs to the phage AlpA excisionase family. {ECO 0000305}. # SUBUNIT Interacts with TorR. Binds to the effector domain of TorR. This interaction, which does not interfere with TorR DNA binding activity, probably prevents the recruitment of RNA polymerase to the torCAD promoter. Binds to DNA. {ECO:0000269|PubMed 15197250}. # eggNOG ENOG41065VV Bacteria # eggNOG ENOG41122W9 LUCA BLAST swissprot:TORI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TORI_ECOLI BioCyc ECOL316407:JW5387-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5387-MONOMER BioCyc EcoCyc:MONOMER0-1641 http://biocyc.org/getid?id=EcoCyc:MONOMER0-1641 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0401927101 http://dx.doi.org/10.1073/pnas.0401927101 DOI 10.1074/jbc.M507409200 http://dx.doi.org/10.1074/jbc.M507409200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14411 http://www.ecogene.org/geneInfo.php?eg_id=EG14411 EnsemblBacteria ABD18695 http://www.ensemblgenomes.org/id/ABD18695 EnsemblBacteria ABD18695 http://www.ensemblgenomes.org/id/ABD18695 EnsemblBacteria BAE76704 http://www.ensemblgenomes.org/id/BAE76704 EnsemblBacteria BAE76704 http://www.ensemblgenomes.org/id/BAE76704 EnsemblBacteria BAE76704 http://www.ensemblgenomes.org/id/BAE76704 EnsemblBacteria b4501 http://www.ensemblgenomes.org/id/b4501 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0044349 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044349 GO_process GO:2000143 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000143 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 1450232 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1450232 HOGENOM HOG000252905 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000252905&db=HOGENOM6 IntAct Q2EES9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q2EES9* KEGG_Gene ecj:JW5387 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5387 KEGG_Gene eco:b4501 http://www.genome.jp/dbget-bin/www_bget?eco:b4501 OMA CAFKSKL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CAFKSKL PDB 1Z4H http://www.ebi.ac.uk/pdbe-srv/view/entry/1Z4H PDBsum 1Z4H http://www.ebi.ac.uk/pdbsum/1Z4H PSORT swissprot:TORI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TORI_ECOLI PSORT-B swissprot:TORI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TORI_ECOLI PSORT2 swissprot:TORI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TORI_ECOLI Phobius swissprot:TORI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TORI_ECOLI ProteinModelPortal Q2EES9 http://www.proteinmodelportal.org/query/uniprot/Q2EES9 PubMed 15197250 http://www.ncbi.nlm.nih.gov/pubmed/15197250 PubMed 16079126 http://www.ncbi.nlm.nih.gov/pubmed/16079126 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001163428 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001163428 RefSeq YP_588463 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_588463 SMR Q2EES9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q2EES9 STRING 511145.b4501 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4501&targetmode=cogs UniProtKB TORI_ECOLI http://www.uniprot.org/uniprot/TORI_ECOLI UniProtKB-AC Q2EES9 http://www.uniprot.org/uniprot/Q2EES9 charge swissprot:TORI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TORI_ECOLI eggNOG ENOG41065VV http://eggnogapi.embl.de/nog_data/html/tree/ENOG41065VV eggNOG ENOG41122W9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41122W9 epestfind swissprot:TORI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TORI_ECOLI garnier swissprot:TORI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TORI_ECOLI helixturnhelix swissprot:TORI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TORI_ECOLI hmoment swissprot:TORI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TORI_ECOLI iep swissprot:TORI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TORI_ECOLI inforesidue swissprot:TORI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TORI_ECOLI octanol swissprot:TORI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TORI_ECOLI pepcoil swissprot:TORI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TORI_ECOLI pepdigest swissprot:TORI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TORI_ECOLI pepinfo swissprot:TORI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TORI_ECOLI pepnet swissprot:TORI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TORI_ECOLI pepstats swissprot:TORI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TORI_ECOLI pepwheel swissprot:TORI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TORI_ECOLI pepwindow swissprot:TORI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TORI_ECOLI sigcleave swissprot:TORI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TORI_ECOLI ## Database ID URL or Descriptions # BioGrid 4262185 5 # EcoGene EG12477 yjeO # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # IntAct P39284 4 # InterPro IPR022553 DUF2645 # Organism YJEO_ECOLI Escherichia coli (strain K12) # PATRIC 32123889 VBIEscCol129921_4292 # PIR S56386 S56386 # Pfam PF10840 DUF2645 # ProDom PD069399 PD069399 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJEO_ECOLI Inner membrane protein YjeO # RefSeq NP_418582 NC_000913.3 # RefSeq WP_001276180 NZ_LN832404.1 # SUBCELLULAR LOCATION YJEO_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG ENOG4106CG8 Bacteria # eggNOG ENOG410XY97 LUCA BLAST swissprot:YJEO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJEO_ECOLI BioCyc ECOL316407:JW4119-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4119-MONOMER BioCyc EcoCyc:G7839-MONOMER http://biocyc.org/getid?id=EcoCyc:G7839-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2370 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2370 EcoGene EG12477 http://www.ecogene.org/geneInfo.php?eg_id=EG12477 EnsemblBacteria AAC77118 http://www.ensemblgenomes.org/id/AAC77118 EnsemblBacteria AAC77118 http://www.ensemblgenomes.org/id/AAC77118 EnsemblBacteria BAE78162 http://www.ensemblgenomes.org/id/BAE78162 EnsemblBacteria BAE78162 http://www.ensemblgenomes.org/id/BAE78162 EnsemblBacteria BAE78162 http://www.ensemblgenomes.org/id/BAE78162 EnsemblBacteria b4158 http://www.ensemblgenomes.org/id/b4158 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 948677 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948677 HOGENOM HOG000127307 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000127307&db=HOGENOM6 IntAct P39284 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39284* InterPro IPR022553 http://www.ebi.ac.uk/interpro/entry/IPR022553 KEGG_Gene ecj:JW4119 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4119 KEGG_Gene eco:b4158 http://www.genome.jp/dbget-bin/www_bget?eco:b4158 OMA PWIVITS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PWIVITS PSORT swissprot:YJEO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJEO_ECOLI PSORT-B swissprot:YJEO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJEO_ECOLI PSORT2 swissprot:YJEO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJEO_ECOLI Pfam PF10840 http://pfam.xfam.org/family/PF10840 Phobius swissprot:YJEO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJEO_ECOLI ProteinModelPortal P39284 http://www.proteinmodelportal.org/query/uniprot/P39284 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418582 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418582 RefSeq WP_001276180 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001276180 STRING 511145.b4158 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4158&targetmode=cogs UniProtKB YJEO_ECOLI http://www.uniprot.org/uniprot/YJEO_ECOLI UniProtKB-AC P39284 http://www.uniprot.org/uniprot/P39284 charge swissprot:YJEO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJEO_ECOLI eggNOG ENOG4106CG8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106CG8 eggNOG ENOG410XY97 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XY97 epestfind swissprot:YJEO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJEO_ECOLI garnier swissprot:YJEO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJEO_ECOLI helixturnhelix swissprot:YJEO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJEO_ECOLI hmoment swissprot:YJEO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJEO_ECOLI iep swissprot:YJEO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJEO_ECOLI inforesidue swissprot:YJEO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJEO_ECOLI octanol swissprot:YJEO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJEO_ECOLI pepcoil swissprot:YJEO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJEO_ECOLI pepdigest swissprot:YJEO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJEO_ECOLI pepinfo swissprot:YJEO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJEO_ECOLI pepnet swissprot:YJEO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJEO_ECOLI pepstats swissprot:YJEO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJEO_ECOLI pepwheel swissprot:YJEO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJEO_ECOLI pepwindow swissprot:YJEO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJEO_ECOLI sigcleave swissprot:YJEO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJEO_ECOLI ## Database ID URL or Descriptions # AltName LSPA_ECOLI Prolipoprotein signal peptidase # AltName LSPA_ECOLI Signal peptidase II # BIOPHYSICOCHEMICAL PROPERTIES LSPA_ECOLI pH dependence Optimum pH is 7.9. {ECO 0000269|PubMed 6368552}; Temperature dependence Optimum temperature is 37-45 degrees Celsius. {ECO 0000269|PubMed 6368552}; # BioGrid 4259402 212 # CATALYTIC ACTIVITY Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|- (S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains. {ECO:0000269|PubMed 6368552}. # ENZYME REGULATION Enzyme activity is inhibited by globomycin, a cyclic peptide antibiotic. {ECO:0000269|PubMed 6368552}. # EcoGene EG10548 lspA # FUNCTION LSPA_ECOLI This protein specifically catalyzes the removal of signal peptides from prolipoproteins. {ECO 0000269|PubMed 6368552, ECO 0000269|PubMed 6374664, ECO 0000269|PubMed 6378662}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0004190 aspartic-type endopeptidase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0008233 peptidase activity; IDA:EcoCyc. # GO_process GO:0006465 signal peptide processing; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0008233 peptidase activity # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0051604 protein maturation # HAMAP MF_00161 LspA # InterPro IPR001872 Peptidase_A8 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # KEGG_Pathway ko03060 Protein export # Organism LSPA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR33695:SF1 PTHR33695:SF1 # PATRIC 32115145 VBIEscCol129921_0024 # PIR C64723 ZPECL # PRINTS PR00781 LIPOSIGPTASE # PROSITE PS00855 SPASE_II # Pfam PF01252 Peptidase_A8 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LSPA_ECOLI Lipoprotein signal peptidase # RefSeq NP_414568 NC_000913.3 # RefSeq WP_000083372 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase A8 family. {ECO 0000305}. # SUBCELLULAR LOCATION LSPA_ECOLI Cell inner membrane {ECO 0000269|PubMed 6368552}; Multi-pass membrane protein {ECO 0000269|PubMed 6368552}. # TIGRFAMs TIGR00077 lspA # eggNOG COG0597 LUCA # eggNOG ENOG4105M02 Bacteria BLAST swissprot:LSPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LSPA_ECOLI BioCyc ECOL316407:JW0025-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0025-MONOMER BioCyc EcoCyc:EG10548-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10548-MONOMER BioCyc MetaCyc:EG10548-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10548-MONOMER COG COG0597 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0597 DIP DIP-10129N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10129N DOI 10.1016/0014-5793(84)81060-1 http://dx.doi.org/10.1016/0014-5793(84)81060-1 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.81.12.3708 http://dx.doi.org/10.1073/pnas.81.12.3708 DOI 10.1093/nar/19.1.180 http://dx.doi.org/10.1093/nar/19.1.180 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.23.36 http://www.genome.jp/dbget-bin/www_bget?EC:3.4.23.36 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K01990 http://www.ebi.ac.uk/ena/data/view/K01990 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X00776 http://www.ebi.ac.uk/ena/data/view/X00776 EMBL X54945 http://www.ebi.ac.uk/ena/data/view/X54945 ENZYME 3.4.23.36 http://enzyme.expasy.org/EC/3.4.23.36 EchoBASE EB0543 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0543 EcoGene EG10548 http://www.ecogene.org/geneInfo.php?eg_id=EG10548 EnsemblBacteria AAC73138 http://www.ensemblgenomes.org/id/AAC73138 EnsemblBacteria AAC73138 http://www.ensemblgenomes.org/id/AAC73138 EnsemblBacteria BAB96596 http://www.ensemblgenomes.org/id/BAB96596 EnsemblBacteria BAB96596 http://www.ensemblgenomes.org/id/BAB96596 EnsemblBacteria BAB96596 http://www.ensemblgenomes.org/id/BAB96596 EnsemblBacteria b0027 http://www.ensemblgenomes.org/id/b0027 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0004190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004190 GO_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GO_process GO:0006465 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006465 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 GeneID 944800 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944800 HAMAP MF_00161 http://hamap.expasy.org/unirule/MF_00161 HOGENOM HOG000096993 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000096993&db=HOGENOM6 InParanoid P00804 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00804 IntEnz 3.4.23.36 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.23.36 InterPro IPR001872 http://www.ebi.ac.uk/interpro/entry/IPR001872 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW0025 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0025 KEGG_Gene eco:b0027 http://www.genome.jp/dbget-bin/www_bget?eco:b0027 KEGG_Orthology KO:K03101 http://www.genome.jp/dbget-bin/www_bget?KO:K03101 KEGG_Pathway ko03060 http://www.genome.jp/kegg-bin/show_pathway?ko03060 OMA DFASKQW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DFASKQW PANTHER PTHR33695:SF1 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR33695:SF1 PRINTS PR00781 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00781 PROSITE PS00855 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00855 PSORT swissprot:LSPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LSPA_ECOLI PSORT-B swissprot:LSPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LSPA_ECOLI PSORT2 swissprot:LSPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LSPA_ECOLI Pfam PF01252 http://pfam.xfam.org/family/PF01252 Phobius swissprot:LSPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LSPA_ECOLI PhylomeDB P00804 http://phylomedb.org/?seqid=P00804 ProteinModelPortal P00804 http://www.proteinmodelportal.org/query/uniprot/P00804 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1894646 http://www.ncbi.nlm.nih.gov/pubmed/1894646 PubMed 2011499 http://www.ncbi.nlm.nih.gov/pubmed/2011499 PubMed 6368552 http://www.ncbi.nlm.nih.gov/pubmed/6368552 PubMed 6374664 http://www.ncbi.nlm.nih.gov/pubmed/6374664 PubMed 6378662 http://www.ncbi.nlm.nih.gov/pubmed/6378662 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414568 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414568 RefSeq WP_000083372 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000083372 SMR P00804 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00804 STRING 511145.b0027 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0027&targetmode=cogs STRING COG0597 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0597&targetmode=cogs TIGRFAMs TIGR00077 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00077 UniProtKB LSPA_ECOLI http://www.uniprot.org/uniprot/LSPA_ECOLI UniProtKB-AC P00804 http://www.uniprot.org/uniprot/P00804 charge swissprot:LSPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LSPA_ECOLI eggNOG COG0597 http://eggnogapi.embl.de/nog_data/html/tree/COG0597 eggNOG ENOG4105M02 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105M02 epestfind swissprot:LSPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LSPA_ECOLI garnier swissprot:LSPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LSPA_ECOLI helixturnhelix swissprot:LSPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LSPA_ECOLI hmoment swissprot:LSPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LSPA_ECOLI iep swissprot:LSPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LSPA_ECOLI inforesidue swissprot:LSPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LSPA_ECOLI octanol swissprot:LSPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LSPA_ECOLI pepcoil swissprot:LSPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LSPA_ECOLI pepdigest swissprot:LSPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LSPA_ECOLI pepinfo swissprot:LSPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LSPA_ECOLI pepnet swissprot:LSPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LSPA_ECOLI pepstats swissprot:LSPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LSPA_ECOLI pepwheel swissprot:LSPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LSPA_ECOLI pepwindow swissprot:LSPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LSPA_ECOLI sigcleave swissprot:LSPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LSPA_ECOLI ## Database ID URL or Descriptions # ENZYME REGULATION GLCA_ECOLI Inhibited by carbonyl cyanide m- chlorophenylhydrazone (CCCP). # EcoGene EG12995 glcA # FUNCTION GLCA_ECOLI Transports glycolate across the membrane. Can also transport L-lactate and D-lactate. Seems to be driven by a proton motive force. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IEA:InterPro. # GO_function GLCA_ECOLI GO 0015295 solute proton symporter activity; IDA EcoCyc. # GO_function GO:0015129 lactate transmembrane transporter activity; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # INDUCTION GLCA_ECOLI By glycolate. # IntAct Q46839 2 # InterPro IPR003804 Lactate_perm # Organism GLCA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30003 PTHR30003 # PATRIC 32121364 VBIEscCol129921_3069 # PIR E65083 E65083 # Pfam PF02652 Lactate_perm # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLCA_ECOLI Glycolate permease GlcA # RefSeq NP_417449 NC_000913.3 # RefSeq WP_000259302 NZ_LN832404.1 # SIMILARITY Belongs to the lactate permease family. {ECO 0000305}. # SUBCELLULAR LOCATION GLCA_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.14.1 the lactate permease (lctp) family # TIGRFAMs TIGR00795 lctP # eggNOG COG1620 LUCA # eggNOG ENOG4105DAA Bacteria BLAST swissprot:GLCA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLCA_ECOLI BioCyc ECOL316407:JW2942-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2942-MONOMER BioCyc EcoCyc:B2975-MONOMER http://biocyc.org/getid?id=EcoCyc:B2975-MONOMER BioCyc MetaCyc:B2975-MONOMER http://biocyc.org/getid?id=MetaCyc:B2975-MONOMER COG COG1620 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1620 DIP DIP-12206N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12206N DOI 10.1006/bbrc.2001.6255 http://dx.doi.org/10.1006/bbrc.2001.6255 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2818 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2818 EcoGene EG12995 http://www.ecogene.org/geneInfo.php?eg_id=EG12995 EnsemblBacteria AAC76011 http://www.ensemblgenomes.org/id/AAC76011 EnsemblBacteria AAC76011 http://www.ensemblgenomes.org/id/AAC76011 EnsemblBacteria BAE77035 http://www.ensemblgenomes.org/id/BAE77035 EnsemblBacteria BAE77035 http://www.ensemblgenomes.org/id/BAE77035 EnsemblBacteria BAE77035 http://www.ensemblgenomes.org/id/BAE77035 EnsemblBacteria b2975 http://www.ensemblgenomes.org/id/b2975 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015129 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015129 GO_function GO:0015295 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015295 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GeneID 947259 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947259 HOGENOM HOG000253321 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000253321&db=HOGENOM6 InParanoid Q46839 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46839 IntAct Q46839 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46839* InterPro IPR003804 http://www.ebi.ac.uk/interpro/entry/IPR003804 KEGG_Gene ecj:JW2942 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2942 KEGG_Gene eco:b2975 http://www.genome.jp/dbget-bin/www_bget?eco:b2975 KEGG_Orthology KO:K02550 http://www.genome.jp/dbget-bin/www_bget?KO:K02550 OMA IRLCAIS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IRLCAIS PANTHER PTHR30003 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30003 PSORT swissprot:GLCA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLCA_ECOLI PSORT-B swissprot:GLCA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLCA_ECOLI PSORT2 swissprot:GLCA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLCA_ECOLI Pfam PF02652 http://pfam.xfam.org/family/PF02652 Phobius swissprot:GLCA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLCA_ECOLI PhylomeDB Q46839 http://phylomedb.org/?seqid=Q46839 ProteinModelPortal Q46839 http://www.proteinmodelportal.org/query/uniprot/Q46839 PubMed 11283302 http://www.ncbi.nlm.nih.gov/pubmed/11283302 PubMed 11785976 http://www.ncbi.nlm.nih.gov/pubmed/11785976 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417449 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417449 RefSeq WP_000259302 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000259302 STRING 511145.b2975 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2975&targetmode=cogs STRING COG1620 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1620&targetmode=cogs TCDB 2.A.14.1 http://www.tcdb.org/search/result.php?tc=2.A.14.1 TIGRFAMs TIGR00795 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00795 UniProtKB GLCA_ECOLI http://www.uniprot.org/uniprot/GLCA_ECOLI UniProtKB-AC Q46839 http://www.uniprot.org/uniprot/Q46839 charge swissprot:GLCA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLCA_ECOLI eggNOG COG1620 http://eggnogapi.embl.de/nog_data/html/tree/COG1620 eggNOG ENOG4105DAA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DAA epestfind swissprot:GLCA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLCA_ECOLI garnier swissprot:GLCA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLCA_ECOLI helixturnhelix swissprot:GLCA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLCA_ECOLI hmoment swissprot:GLCA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLCA_ECOLI iep swissprot:GLCA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLCA_ECOLI inforesidue swissprot:GLCA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLCA_ECOLI octanol swissprot:GLCA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLCA_ECOLI pepcoil swissprot:GLCA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLCA_ECOLI pepdigest swissprot:GLCA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLCA_ECOLI pepinfo swissprot:GLCA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLCA_ECOLI pepnet swissprot:GLCA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLCA_ECOLI pepstats swissprot:GLCA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLCA_ECOLI pepwheel swissprot:GLCA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLCA_ECOLI pepwindow swissprot:GLCA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLCA_ECOLI sigcleave swissprot:GLCA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLCA_ECOLI ## Database ID URL or Descriptions # AltName Phosphoribulose isomerase {ECO:0000255|HAMAP-Rule MF_00989} # CATALYTIC ACTIVITY L-ribulose 5-phosphate = D-xylulose 5- phosphate. {ECO:0000255|HAMAP-Rule MF_00989}. # COFACTOR ARAD_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000255|HAMAP-Rule MF_00989, ECO 0000269|PubMed 11732895}; Note=Binds 1 zinc ion per subunit. {ECO 0000255|HAMAP- Rule MF_00989, ECO 0000269|PubMed 11732895}; # EcoGene EG10055 araD # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IEA:InterPro. # GO_function GO:0008742 L-ribulose-phosphate 4-epimerase activity; IDA:EcoCyc. # GO_function GO:0016832 aldehyde-lyase activity; IBA:GO_Central. # GO_process GO:0019324 L-lyxose metabolic process; IMP:EcoCyc. # GO_process GO:0019569 L-arabinose catabolic process to xylulose 5-phosphate; IEP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.225.10 -; 1. # HAMAP MF_00989 AraD_entero # IntAct P08203 4 # InterPro IPR001303 Aldolase_II/adducin_N # InterPro IPR004661 AraD # InterPro IPR033748 AraD_entero # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00040 Pentose and glucuronate interconversions # Organism ARAD_ECOLI Escherichia coli (strain K12) # PATHWAY Carbohydrate degradation; L-arabinose degradation via L- ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 3/3. {ECO 0000255|HAMAP-Rule:MF_00989}. # PATRIC 32115223 VBIEscCol129921_0063 # PDB 1JDI X-ray; 2.40 A; A/B/C/D/E/F=1-231 # PDB 1K0W X-ray; 2.10 A; A/B/C/D/E/F=1-231 # PIR E64727 ISECP4 # Pfam PF00596 Aldolase_II # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName L-ribulose-5-phosphate 4-epimerase {ECO:0000255|HAMAP-Rule MF_00989} # RefSeq NP_414603 NC_000913.3 # RefSeq WP_000888666 NZ_LN832404.1 # SIMILARITY Belongs to the aldolase class II family. AraD/FucA subfamily. {ECO:0000255|HAMAP-Rule MF_00989}. # SMART SM01007 Aldolase_II # SUBUNIT ARAD_ECOLI Homotetramer. {ECO 0000255|HAMAP-Rule MF_00989, ECO 0000269|PubMed 11732895, ECO 0000269|PubMed 4879898}. # SUPFAM SSF53639 SSF53639 # TIGRFAMs TIGR00760 araD # UniPathway UPA00145 UER00567 # eggNOG COG0235 LUCA # eggNOG ENOG4107R0P Bacteria BLAST swissprot:ARAD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARAD_ECOLI BioCyc ECOL316407:JW0060-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0060-MONOMER BioCyc EcoCyc:RIBULPEPIM-MONOMER http://biocyc.org/getid?id=EcoCyc:RIBULPEPIM-MONOMER BioCyc MetaCyc:RIBULPEPIM-MONOMER http://biocyc.org/getid?id=MetaCyc:RIBULPEPIM-MONOMER COG COG0235 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0235 DIP DIP-9126N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9126N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/pro.5560040823 http://dx.doi.org/10.1002/pro.5560040823 DOI 10.1007/BF00273583 http://dx.doi.org/10.1007/BF00273583 DOI 10.1016/0378-1119(86)90067-3 http://dx.doi.org/10.1016/0378-1119(86)90067-3 DOI 10.1021/bi0112513 http://dx.doi.org/10.1021/bi0112513 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.87.19.7663 http://dx.doi.org/10.1073/pnas.87.19.7663 DOI 10.1089/dna.1990.9.631 http://dx.doi.org/10.1089/dna.1990.9.631 DOI 10.1093/nar/18.22.6722 http://dx.doi.org/10.1093/nar/18.22.6722 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.1.3.4 {ECO:0000255|HAMAP-Rule:MF_00989} http://www.genome.jp/dbget-bin/www_bget?EC:5.1.3.4 {ECO:0000255|HAMAP-Rule:MF_00989} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M15263 http://www.ebi.ac.uk/ena/data/view/M15263 EMBL M35371 http://www.ebi.ac.uk/ena/data/view/M35371 EMBL M37727 http://www.ebi.ac.uk/ena/data/view/M37727 EMBL M38283 http://www.ebi.ac.uk/ena/data/view/M38283 EMBL M62646 http://www.ebi.ac.uk/ena/data/view/M62646 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X56048 http://www.ebi.ac.uk/ena/data/view/X56048 ENZYME 5.1.3.4 {ECO:0000255|HAMAP-Rule:MF_00989} http://enzyme.expasy.org/EC/5.1.3.4 {ECO:0000255|HAMAP-Rule:MF_00989} EchoBASE EB0053 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0053 EcoGene EG10055 http://www.ecogene.org/geneInfo.php?eg_id=EG10055 EnsemblBacteria AAC73172 http://www.ensemblgenomes.org/id/AAC73172 EnsemblBacteria AAC73172 http://www.ensemblgenomes.org/id/AAC73172 EnsemblBacteria BAB96630 http://www.ensemblgenomes.org/id/BAB96630 EnsemblBacteria BAB96630 http://www.ensemblgenomes.org/id/BAB96630 EnsemblBacteria BAB96630 http://www.ensemblgenomes.org/id/BAB96630 EnsemblBacteria b0061 http://www.ensemblgenomes.org/id/b0061 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0008742 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008742 GO_function GO:0016832 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016832 GO_process GO:0019324 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019324 GO_process GO:0019569 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019569 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.225.10 http://www.cathdb.info/version/latest/superfamily/3.40.225.10 GeneID 945294 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945294 HAMAP MF_00989 http://hamap.expasy.org/unirule/MF_00989 HOGENOM HOG000218183 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218183&db=HOGENOM6 InParanoid P08203 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P08203 IntAct P08203 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P08203* IntEnz 5.1.3.4 {ECO:0000255|HAMAP-Rule:MF_00989} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.1.3.4 {ECO:0000255|HAMAP-Rule:MF_00989} InterPro IPR001303 http://www.ebi.ac.uk/interpro/entry/IPR001303 InterPro IPR004661 http://www.ebi.ac.uk/interpro/entry/IPR004661 InterPro IPR033748 http://www.ebi.ac.uk/interpro/entry/IPR033748 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0060 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0060 KEGG_Gene eco:b0061 http://www.genome.jp/dbget-bin/www_bget?eco:b0061 KEGG_Orthology KO:K01786 http://www.genome.jp/dbget-bin/www_bget?KO:K01786 KEGG_Pathway ko00040 http://www.genome.jp/kegg-bin/show_pathway?ko00040 KEGG_Reaction rn:R05850 http://www.genome.jp/dbget-bin/www_bget?rn:R05850 OMA HSPWAVS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HSPWAVS PDB 1JDI http://www.ebi.ac.uk/pdbe-srv/view/entry/1JDI PDB 1K0W http://www.ebi.ac.uk/pdbe-srv/view/entry/1K0W PDBsum 1JDI http://www.ebi.ac.uk/pdbsum/1JDI PDBsum 1K0W http://www.ebi.ac.uk/pdbsum/1K0W PSORT swissprot:ARAD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARAD_ECOLI PSORT-B swissprot:ARAD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARAD_ECOLI PSORT2 swissprot:ARAD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARAD_ECOLI Pfam PF00596 http://pfam.xfam.org/family/PF00596 Phobius swissprot:ARAD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARAD_ECOLI PhylomeDB P08203 http://phylomedb.org/?seqid=P08203 ProteinModelPortal P08203 http://www.proteinmodelportal.org/query/uniprot/P08203 PubMed 11732895 http://www.ncbi.nlm.nih.gov/pubmed/11732895 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2034216 http://www.ncbi.nlm.nih.gov/pubmed/2034216 PubMed 2217198 http://www.ncbi.nlm.nih.gov/pubmed/2217198 PubMed 2251150 http://www.ncbi.nlm.nih.gov/pubmed/2251150 PubMed 2261080 http://www.ncbi.nlm.nih.gov/pubmed/2261080 PubMed 3549454 http://www.ncbi.nlm.nih.gov/pubmed/3549454 PubMed 4879898 http://www.ncbi.nlm.nih.gov/pubmed/4879898 PubMed 8520491 http://www.ncbi.nlm.nih.gov/pubmed/8520491 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_414603 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414603 RefSeq WP_000888666 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000888666 SMART SM01007 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01007 SMR P08203 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P08203 STRING 511145.b0061 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0061&targetmode=cogs STRING COG0235 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0235&targetmode=cogs SUPFAM SSF53639 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53639 TIGRFAMs TIGR00760 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00760 UniProtKB ARAD_ECOLI http://www.uniprot.org/uniprot/ARAD_ECOLI UniProtKB-AC P08203 http://www.uniprot.org/uniprot/P08203 charge swissprot:ARAD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARAD_ECOLI eggNOG COG0235 http://eggnogapi.embl.de/nog_data/html/tree/COG0235 eggNOG ENOG4107R0P http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107R0P epestfind swissprot:ARAD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARAD_ECOLI garnier swissprot:ARAD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARAD_ECOLI helixturnhelix swissprot:ARAD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARAD_ECOLI hmoment swissprot:ARAD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARAD_ECOLI iep swissprot:ARAD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARAD_ECOLI inforesidue swissprot:ARAD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARAD_ECOLI octanol swissprot:ARAD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARAD_ECOLI pepcoil swissprot:ARAD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARAD_ECOLI pepdigest swissprot:ARAD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARAD_ECOLI pepinfo swissprot:ARAD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARAD_ECOLI pepnet swissprot:ARAD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARAD_ECOLI pepstats swissprot:ARAD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARAD_ECOLI pepwheel swissprot:ARAD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARAD_ECOLI pepwindow swissprot:ARAD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARAD_ECOLI sigcleave swissprot:ARAD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARAD_ECOLI ## Database ID URL or Descriptions # BioGrid 4260724 230 # CDD cd07185 OmpA_C-like # EcoGene EG10684 pal # FUNCTION PAL_ECOLI Thought to play a role in bacterial envelope integrity. Very strongly associated with the peptidoglycan. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:InterPro. # GO_component GO:0031246 intrinsic component of periplasmic side of cell outer membrane; IDA:EcoCyc. # GO_component GO:0032153 cell division site; IDA:EcoCyc. # GO_process GO:0051301 cell division; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0051301 cell division # Gene3D 3.30.1330.60 -; 1. # INTERACTION PAL_ECOLI P75958 lolE; NbExp=2; IntAct=EBI-1124760, EBI-1125190; P0A855 tolB; NbExp=4; IntAct=EBI-1124760, EBI-7180728; # IntAct P0A912 8 # InterPro IPR006664 OMP_bac # InterPro IPR006665 OmpA-like # InterPro IPR006690 OMPA-like_CS # InterPro IPR014169 Pal_lipo # KEGG_Brite ko02000 Transporters # Organism PAL_ECOLI Escherichia coli (strain K12) # PATRIC 32116681 VBIEscCol129921_0773 # PDB 1OAP X-ray; 1.93 A; A=65-173 # PDB 2HQS X-ray; 1.50 A; C/E/G/H=65-173 # PDB 2W8B X-ray; 1.86 A; C/E/G/H=65-173 # PIR A27534 LPECPG # PRINTS PR01021 OMPADOMAIN # PROSITE PS01068 OMPA_1 # PROSITE PS51123 OMPA_2 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF00691 OmpA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PAL_ECOLI Peptidoglycan-associated lipoprotein # RefSeq NP_415269 NC_000913.3 # RefSeq WP_001295306 NZ_LN832404.1 # SIMILARITY Belongs to the OmpA family. Pal subfamily. {ECO 0000305}. # SIMILARITY Contains 1 OmpA-like domain. {ECO:0000255|PROSITE- ProRule PRU00473}. # SUBCELLULAR LOCATION PAL_ECOLI Cell outer membrane; Lipid-anchor. # SUPFAM SSF103088 SSF103088 # TIGRFAMs TIGR02802 Pal_lipo # eggNOG COG2885 LUCA # eggNOG ENOG4105KCK Bacteria BLAST swissprot:PAL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PAL_ECOLI BioCyc ECOL316407:JW0731-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0731-MONOMER BioCyc EcoCyc:EG10684-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10684-MONOMER COG COG2885 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2885 DIP DIP-51001N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-51001N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1107/S0907444900019739 http://dx.doi.org/10.1107/S0907444900019739 DOI 10.1111/j.1365-2958.1992.tb01523.x http://dx.doi.org/10.1111/j.1365-2958.1992.tb01523.x DOI 10.1111/j.1432-1033.1987.tb10738.x http://dx.doi.org/10.1111/j.1432-1033.1987.tb10738.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M28232 http://www.ebi.ac.uk/ena/data/view/M28232 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X05123 http://www.ebi.ac.uk/ena/data/view/X05123 EMBL X65796 http://www.ebi.ac.uk/ena/data/view/X65796 EchoBASE EB0678 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0678 EcoGene EG10684 http://www.ecogene.org/geneInfo.php?eg_id=EG10684 EnsemblBacteria AAC73835 http://www.ensemblgenomes.org/id/AAC73835 EnsemblBacteria AAC73835 http://www.ensemblgenomes.org/id/AAC73835 EnsemblBacteria BAA35407 http://www.ensemblgenomes.org/id/BAA35407 EnsemblBacteria BAA35407 http://www.ensemblgenomes.org/id/BAA35407 EnsemblBacteria BAA35407 http://www.ensemblgenomes.org/id/BAA35407 EnsemblBacteria b0741 http://www.ensemblgenomes.org/id/b0741 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0031246 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031246 GO_component GO:0032153 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032153 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 Gene3D 3.30.1330.60 http://www.cathdb.info/version/latest/superfamily/3.30.1330.60 GeneID 945004 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945004 HOGENOM HOG000189913 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000189913&db=HOGENOM6 InParanoid P0A912 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A912 IntAct P0A912 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A912* InterPro IPR006664 http://www.ebi.ac.uk/interpro/entry/IPR006664 InterPro IPR006665 http://www.ebi.ac.uk/interpro/entry/IPR006665 InterPro IPR006690 http://www.ebi.ac.uk/interpro/entry/IPR006690 InterPro IPR014169 http://www.ebi.ac.uk/interpro/entry/IPR014169 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0731 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0731 KEGG_Gene eco:b0741 http://www.genome.jp/dbget-bin/www_bget?eco:b0741 KEGG_Orthology KO:K03640 http://www.genome.jp/dbget-bin/www_bget?KO:K03640 MINT MINT-7259928 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-7259928 OMA RLMIEGH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RLMIEGH PDB 1OAP http://www.ebi.ac.uk/pdbe-srv/view/entry/1OAP PDB 2HQS http://www.ebi.ac.uk/pdbe-srv/view/entry/2HQS PDB 2W8B http://www.ebi.ac.uk/pdbe-srv/view/entry/2W8B PDBsum 1OAP http://www.ebi.ac.uk/pdbsum/1OAP PDBsum 2HQS http://www.ebi.ac.uk/pdbsum/2HQS PDBsum 2W8B http://www.ebi.ac.uk/pdbsum/2W8B PRINTS PR01021 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01021 PROSITE PS01068 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01068 PROSITE PS51123 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51123 PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:PAL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PAL_ECOLI PSORT-B swissprot:PAL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PAL_ECOLI PSORT2 swissprot:PAL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PAL_ECOLI Pfam PF00691 http://pfam.xfam.org/family/PF00691 Phobius swissprot:PAL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PAL_ECOLI PhylomeDB P0A912 http://phylomedb.org/?seqid=P0A912 ProteinModelPortal P0A912 http://www.proteinmodelportal.org/query/uniprot/P0A912 PubMed 11173492 http://www.ncbi.nlm.nih.gov/pubmed/11173492 PubMed 1574003 http://www.ncbi.nlm.nih.gov/pubmed/1574003 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2687247 http://www.ncbi.nlm.nih.gov/pubmed/2687247 PubMed 3545827 http://www.ncbi.nlm.nih.gov/pubmed/3545827 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415269 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415269 RefSeq WP_001295306 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295306 SMR P0A912 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A912 STRING 511145.b0741 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0741&targetmode=cogs STRING COG2885 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2885&targetmode=cogs SUPFAM SSF103088 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103088 TIGRFAMs TIGR02802 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02802 UniProtKB PAL_ECOLI http://www.uniprot.org/uniprot/PAL_ECOLI UniProtKB-AC P0A912 http://www.uniprot.org/uniprot/P0A912 charge swissprot:PAL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PAL_ECOLI eggNOG COG2885 http://eggnogapi.embl.de/nog_data/html/tree/COG2885 eggNOG ENOG4105KCK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KCK epestfind swissprot:PAL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PAL_ECOLI garnier swissprot:PAL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PAL_ECOLI helixturnhelix swissprot:PAL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PAL_ECOLI hmoment swissprot:PAL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PAL_ECOLI iep swissprot:PAL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PAL_ECOLI inforesidue swissprot:PAL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PAL_ECOLI octanol swissprot:PAL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PAL_ECOLI pepcoil swissprot:PAL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PAL_ECOLI pepdigest swissprot:PAL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PAL_ECOLI pepinfo swissprot:PAL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PAL_ECOLI pepnet swissprot:PAL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PAL_ECOLI pepstats swissprot:PAL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PAL_ECOLI pepwheel swissprot:PAL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PAL_ECOLI pepwindow swissprot:PAL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PAL_ECOLI sigcleave swissprot:PAL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PAL_ECOLI ## Database ID URL or Descriptions # AltName AMY1_ECOLI 1,4-alpha-D-glucan glucanohydrolase # BioGrid 4261712 8 # CATALYTIC ACTIVITY AMY1_ECOLI Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha- linked D-glucose units. # CAZy GH13 Glycoside Hydrolase Family 13 # COFACTOR AMY1_ECOLI Name=Ca(2+); Xref=ChEBI CHEBI 29108; Evidence={ECO 0000250}; Note=Binds 1 Ca(2+) ion per subunit. {ECO 0000250}; # EcoGene EG11316 malS # FUNCTION AMY1_ECOLI Since only maltooligosaccharides up to a chain length of 6 glucose units are actively transported through the cytoplasmic membrane via the membrane-bound complex of three proteins, MalF, MalG, and MalK, longer maltooligosaccharides must first be degraded by the periplasmic alpha-amylase, the MalS protein. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_component GO:0042597 periplasmic space; IDA:EcoliWiki. # GO_function GO:0004556 alpha-amylase activity; IDA:EcoliWiki. # GO_function GO:0005509 calcium ion binding; IDA:EcoCyc. # GO_process GO:0030980 alpha-glucan catabolic process; IMP:EcoCyc. # GO_process GO:0051692 cellular oligosaccharide catabolic process; IDA:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # Gene3D 3.20.20.80 -; 1. # INDUCTION AMY1_ECOLI Under the regulatory control of the MalT protein. # InterPro IPR006047 Glyco_hydro_13_cat_dom # InterPro IPR013781 Glyco_hydro_catalytic_dom # InterPro IPR014635 A_amylase_MalS # InterPro IPR015902 Glyco_hydro_13 # InterPro IPR017853 Glycoside_hydrolase_SF # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00500 Starch and sucrose metabolism # KEGG_Pathway ko04973 Carbohydrate digestion and absorption # Organism AMY1_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10357 PTHR10357; 4 # PATRIC 32122618 VBIEscCol129921_3686 # PIR S23807 S23807 # PIRSF PIRSF036917 Alph_amls_MalS # Pfam PF00128 Alpha-amylase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AMY1_ECOLI Alpha-amylase # RefSeq NP_418028 NC_000913.3 # RefSeq WP_000761225 NZ_LN832404.1 # SIMILARITY Belongs to the glycosyl hydrolase 13 family. {ECO 0000305}. # SMART SM00642 Aamy # SUBCELLULAR LOCATION AMY1_ECOLI Periplasm. # SUBUNIT AMY1_ECOLI Monomer. # SUPFAM SSF51445 SSF51445; 2 # eggNOG COG0366 LUCA # eggNOG ENOG4107T9C Bacteria BLAST swissprot:AMY1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AMY1_ECOLI BioCyc ECOL316407:JW3543-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3543-MONOMER BioCyc EcoCyc:ALPHA-AMYL-PERI-MONOMER http://biocyc.org/getid?id=EcoCyc:ALPHA-AMYL-PERI-MONOMER BioCyc MetaCyc:ALPHA-AMYL-PERI-MONOMER http://biocyc.org/getid?id=MetaCyc:ALPHA-AMYL-PERI-MONOMER COG COG0366 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0366 DIP DIP-10148N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10148N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.272.35.22125 http://dx.doi.org/10.1074/jbc.272.35.22125 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.2.1.1 http://www.genome.jp/dbget-bin/www_bget?EC:3.2.1.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X58994 http://www.ebi.ac.uk/ena/data/view/X58994 ENZYME 3.2.1.1 http://enzyme.expasy.org/EC/3.2.1.1 EchoBASE EB1292 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1292 EcoGene EG11316 http://www.ecogene.org/geneInfo.php?eg_id=EG11316 EnsemblBacteria AAC76595 http://www.ensemblgenomes.org/id/AAC76595 EnsemblBacteria AAC76595 http://www.ensemblgenomes.org/id/AAC76595 EnsemblBacteria BAE77722 http://www.ensemblgenomes.org/id/BAE77722 EnsemblBacteria BAE77722 http://www.ensemblgenomes.org/id/BAE77722 EnsemblBacteria BAE77722 http://www.ensemblgenomes.org/id/BAE77722 EnsemblBacteria b3571 http://www.ensemblgenomes.org/id/b3571 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0004556 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004556 GO_function GO:0005509 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509 GO_process GO:0030980 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030980 GO_process GO:0051692 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051692 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 3.20.20.80 http://www.cathdb.info/version/latest/superfamily/3.20.20.80 GeneID 948088 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948088 HOGENOM HOG000273912 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000273912&db=HOGENOM6 InParanoid P25718 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P25718 IntAct P25718 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P25718* IntEnz 3.2.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.2.1.1 InterPro IPR006047 http://www.ebi.ac.uk/interpro/entry/IPR006047 InterPro IPR013781 http://www.ebi.ac.uk/interpro/entry/IPR013781 InterPro IPR014635 http://www.ebi.ac.uk/interpro/entry/IPR014635 InterPro IPR015902 http://www.ebi.ac.uk/interpro/entry/IPR015902 InterPro IPR017853 http://www.ebi.ac.uk/interpro/entry/IPR017853 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3543 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3543 KEGG_Gene eco:b3571 http://www.genome.jp/dbget-bin/www_bget?eco:b3571 KEGG_Orthology KO:K01176 http://www.genome.jp/dbget-bin/www_bget?KO:K01176 KEGG_Pathway ko00500 http://www.genome.jp/kegg-bin/show_pathway?ko00500 KEGG_Pathway ko04973 http://www.genome.jp/kegg-bin/show_pathway?ko04973 KEGG_Reaction rn:R02108 http://www.genome.jp/dbget-bin/www_bget?rn:R02108 MINT MINT-1293484 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1293484 OMA DKVMVVW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DKVMVVW PANTHER PTHR10357 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10357 PSORT swissprot:AMY1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AMY1_ECOLI PSORT-B swissprot:AMY1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AMY1_ECOLI PSORT2 swissprot:AMY1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AMY1_ECOLI Pfam PF00128 http://pfam.xfam.org/family/PF00128 Phobius swissprot:AMY1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AMY1_ECOLI PhylomeDB P25718 http://phylomedb.org/?seqid=P25718 ProteinModelPortal P25718 http://www.proteinmodelportal.org/query/uniprot/P25718 PubMed 1544897 http://www.ncbi.nlm.nih.gov/pubmed/1544897 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9268356 http://www.ncbi.nlm.nih.gov/pubmed/9268356 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418028 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418028 RefSeq WP_000761225 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000761225 SMART SM00642 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00642 STRING 511145.b3571 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3571&targetmode=cogs STRING COG0366 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0366&targetmode=cogs SUPFAM SSF51445 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51445 UniProtKB AMY1_ECOLI http://www.uniprot.org/uniprot/AMY1_ECOLI UniProtKB-AC P25718 http://www.uniprot.org/uniprot/P25718 charge swissprot:AMY1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AMY1_ECOLI eggNOG COG0366 http://eggnogapi.embl.de/nog_data/html/tree/COG0366 eggNOG ENOG4107T9C http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107T9C epestfind swissprot:AMY1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AMY1_ECOLI garnier swissprot:AMY1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AMY1_ECOLI helixturnhelix swissprot:AMY1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AMY1_ECOLI hmoment swissprot:AMY1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AMY1_ECOLI iep swissprot:AMY1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AMY1_ECOLI inforesidue swissprot:AMY1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AMY1_ECOLI octanol swissprot:AMY1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AMY1_ECOLI pepcoil swissprot:AMY1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AMY1_ECOLI pepdigest swissprot:AMY1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AMY1_ECOLI pepinfo swissprot:AMY1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AMY1_ECOLI pepnet swissprot:AMY1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AMY1_ECOLI pepstats swissprot:AMY1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AMY1_ECOLI pepwheel swissprot:AMY1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AMY1_ECOLI pepwindow swissprot:AMY1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AMY1_ECOLI sigcleave swissprot:AMY1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AMY1_ECOLI ## Database ID URL or Descriptions # BioGrid 4262026 16 # COFACTOR NSRR_ECOLI Name=[2Fe-2S] cluster; Xref=ChEBI CHEBI 49601; Evidence={ECO 0000305}; Note=Binds 1 [2Fe-2S] cluster per subunit. {ECO 0000305}; # EcoGene EG11212 nsrR # FUNCTION NSRR_ECOLI Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress, such as ytfE, hmpA and ygbA. May require iron for activity. Does not regulates its own transcription. {ECO 0000269|PubMed 16428390}. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0003690 double-stranded DNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0005506 iron ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0051537 2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-HAMAP. # GO_process GO:0006355 regulation of transcription, DNA-templated; IMP:EcoCyc. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IEA:InterPro. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # HAMAP MF_01177 HTH_type_NsrR # InterPro IPR000944 Tscrpt_reg_Rrf2-type # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR023761 Tscrpt_rep_HTH_NsrR # InterPro IPR030489 TR_Rrf2-type_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko03000 Transcription factors # KEGG_Pathway ko05132 Salmonella infection # Organism NSRR_ECOLI Escherichia coli (strain K12) # PATRIC 32123929 VBIEscCol129921_4309 # PIR S56403 S56403 # PROSITE PS01332 HTH_RRF2_1 # PROSITE PS51197 HTH_RRF2_2 # Pfam PF02082 Rrf2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NSRR_ECOLI HTH-type transcriptional repressor NsrR # RefSeq NP_418599 NC_000913.3 # RefSeq WP_001177639 NZ_LN832404.1 # SIMILARITY Contains 1 HTH rrf2-type DNA-binding domain. {ECO 0000305}. # SUPFAM SSF46785 SSF46785 # TIGRFAMs TIGR00738 rrf2_super # eggNOG COG1959 LUCA # eggNOG ENOG4105KPV Bacteria BLAST swissprot:NSRR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NSRR_ECOLI BioCyc ECOL316407:JW4136-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4136-MONOMER BioCyc EcoCyc:EG11212-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11212-MONOMER COG COG1959 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1959 DIP DIP-48211N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48211N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.188.3.874-881.2006 http://dx.doi.org/10.1128/JB.188.3.874-881.2006 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J04199 http://www.ebi.ac.uk/ena/data/view/J04199 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB1197 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1197 EcoGene EG11212 http://www.ecogene.org/geneInfo.php?eg_id=EG11212 EnsemblBacteria AAC77135 http://www.ensemblgenomes.org/id/AAC77135 EnsemblBacteria AAC77135 http://www.ensemblgenomes.org/id/AAC77135 EnsemblBacteria BAE78179 http://www.ensemblgenomes.org/id/BAE78179 EnsemblBacteria BAE78179 http://www.ensemblgenomes.org/id/BAE78179 EnsemblBacteria BAE78179 http://www.ensemblgenomes.org/id/BAE78179 EnsemblBacteria b4178 http://www.ensemblgenomes.org/id/b4178 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003690 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003690 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0051537 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051537 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 948693 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948693 HAMAP MF_01177 http://hamap.expasy.org/unirule/MF_01177 HOGENOM HOG000249814 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000249814&db=HOGENOM6 InParanoid P0AF63 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AF63 IntAct P0AF63 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AF63* InterPro IPR000944 http://www.ebi.ac.uk/interpro/entry/IPR000944 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR023761 http://www.ebi.ac.uk/interpro/entry/IPR023761 InterPro IPR030489 http://www.ebi.ac.uk/interpro/entry/IPR030489 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW4136 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4136 KEGG_Gene eco:b4178 http://www.genome.jp/dbget-bin/www_bget?eco:b4178 KEGG_Orthology KO:K13771 http://www.genome.jp/dbget-bin/www_bget?KO:K13771 KEGG_Pathway ko05132 http://www.genome.jp/kegg-bin/show_pathway?ko05132 OMA LMKVIYR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LMKVIYR PROSITE PS01332 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01332 PROSITE PS51197 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51197 PSORT swissprot:NSRR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NSRR_ECOLI PSORT-B swissprot:NSRR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NSRR_ECOLI PSORT2 swissprot:NSRR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NSRR_ECOLI Pfam PF02082 http://pfam.xfam.org/family/PF02082 Phobius swissprot:NSRR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NSRR_ECOLI PhylomeDB P0AF63 http://phylomedb.org/?seqid=P0AF63 ProteinModelPortal P0AF63 http://www.proteinmodelportal.org/query/uniprot/P0AF63 PubMed 16428390 http://www.ncbi.nlm.nih.gov/pubmed/16428390 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3058695 http://www.ncbi.nlm.nih.gov/pubmed/3058695 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418599 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418599 RefSeq WP_001177639 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001177639 SMR P0AF63 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AF63 STRING 511145.b4178 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4178&targetmode=cogs STRING COG1959 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1959&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 TIGRFAMs TIGR00738 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00738 UniProtKB NSRR_ECOLI http://www.uniprot.org/uniprot/NSRR_ECOLI UniProtKB-AC P0AF63 http://www.uniprot.org/uniprot/P0AF63 charge swissprot:NSRR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NSRR_ECOLI eggNOG COG1959 http://eggnogapi.embl.de/nog_data/html/tree/COG1959 eggNOG ENOG4105KPV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KPV epestfind swissprot:NSRR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NSRR_ECOLI garnier swissprot:NSRR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NSRR_ECOLI helixturnhelix swissprot:NSRR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NSRR_ECOLI hmoment swissprot:NSRR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NSRR_ECOLI iep swissprot:NSRR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NSRR_ECOLI inforesidue swissprot:NSRR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NSRR_ECOLI octanol swissprot:NSRR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NSRR_ECOLI pepcoil swissprot:NSRR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NSRR_ECOLI pepdigest swissprot:NSRR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NSRR_ECOLI pepinfo swissprot:NSRR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NSRR_ECOLI pepnet swissprot:NSRR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NSRR_ECOLI pepstats swissprot:NSRR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NSRR_ECOLI pepwheel swissprot:NSRR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NSRR_ECOLI pepwindow swissprot:NSRR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NSRR_ECOLI sigcleave swissprot:NSRR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NSRR_ECOLI ## Database ID URL or Descriptions # BioGrid 4259447 18 # EcoGene EG13181 hslJ # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_process GO:0009408 response to heat; IEP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0006950 response to stress # InterPro IPR005184 DUF306_Meta_HslJ # Organism HSLJ_ECOLI Escherichia coli (strain K12) # PATRIC 32118044 VBIEscCol129921_1442 # PDB 2KTS NMR; -; A=25-140 # PIR F64888 F64888 # Pfam PF03724 META # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HSLJ_ECOLI Heat shock protein HslJ # RefSeq NP_415897 NC_000913.3 # RefSeq WP_001298828 NZ_LN832404.1 # eggNOG COG3187 LUCA # eggNOG ENOG41090X5 Bacteria BLAST swissprot:HSLJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HSLJ_ECOLI BioCyc ECOL316407:JW1374-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1374-MONOMER BioCyc EcoCyc:G6702-MONOMER http://biocyc.org/getid?id=EcoCyc:G6702-MONOMER COG COG3187 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3187 DIP DIP-9946N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9946N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1099/00221287-143-1-187 http://dx.doi.org/10.1099/00221287-143-1-187 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36928 http://www.ebi.ac.uk/ena/data/view/U36928 EchoBASE EB2973 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2973 EcoGene EG13181 http://www.ecogene.org/geneInfo.php?eg_id=EG13181 EnsemblBacteria AAC74461 http://www.ensemblgenomes.org/id/AAC74461 EnsemblBacteria AAC74461 http://www.ensemblgenomes.org/id/AAC74461 EnsemblBacteria BAA14984 http://www.ensemblgenomes.org/id/BAA14984 EnsemblBacteria BAA14984 http://www.ensemblgenomes.org/id/BAA14984 EnsemblBacteria BAA14984 http://www.ensemblgenomes.org/id/BAA14984 EnsemblBacteria b1379 http://www.ensemblgenomes.org/id/b1379 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 946525 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946525 HOGENOM HOG000284627 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000284627&db=HOGENOM6 InterPro IPR005184 http://www.ebi.ac.uk/interpro/entry/IPR005184 KEGG_Gene ecj:JW1374 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1374 KEGG_Gene eco:b1379 http://www.genome.jp/dbget-bin/www_bget?eco:b1379 KEGG_Orthology KO:K03668 http://www.genome.jp/dbget-bin/www_bget?KO:K03668 OMA GVMCNRF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GVMCNRF PDB 2KTS http://www.ebi.ac.uk/pdbe-srv/view/entry/2KTS PDBsum 2KTS http://www.ebi.ac.uk/pdbsum/2KTS PSORT swissprot:HSLJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HSLJ_ECOLI PSORT-B swissprot:HSLJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HSLJ_ECOLI PSORT2 swissprot:HSLJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HSLJ_ECOLI Pfam PF03724 http://pfam.xfam.org/family/PF03724 Phobius swissprot:HSLJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HSLJ_ECOLI ProteinModelPortal P52644 http://www.proteinmodelportal.org/query/uniprot/P52644 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8349564 http://www.ncbi.nlm.nih.gov/pubmed/8349564 PubMed 9025293 http://www.ncbi.nlm.nih.gov/pubmed/9025293 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415897 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415897 RefSeq WP_001298828 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001298828 SMR P52644 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P52644 STRING 511145.b1379 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1379&targetmode=cogs STRING COG3187 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3187&targetmode=cogs UniProtKB HSLJ_ECOLI http://www.uniprot.org/uniprot/HSLJ_ECOLI UniProtKB-AC P52644 http://www.uniprot.org/uniprot/P52644 charge swissprot:HSLJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HSLJ_ECOLI eggNOG COG3187 http://eggnogapi.embl.de/nog_data/html/tree/COG3187 eggNOG ENOG41090X5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41090X5 epestfind swissprot:HSLJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HSLJ_ECOLI garnier swissprot:HSLJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HSLJ_ECOLI helixturnhelix swissprot:HSLJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HSLJ_ECOLI hmoment swissprot:HSLJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HSLJ_ECOLI iep swissprot:HSLJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HSLJ_ECOLI inforesidue swissprot:HSLJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HSLJ_ECOLI octanol swissprot:HSLJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HSLJ_ECOLI pepcoil swissprot:HSLJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HSLJ_ECOLI pepdigest swissprot:HSLJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HSLJ_ECOLI pepinfo swissprot:HSLJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HSLJ_ECOLI pepnet swissprot:HSLJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HSLJ_ECOLI pepstats swissprot:HSLJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HSLJ_ECOLI pepwheel swissprot:HSLJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HSLJ_ECOLI pepwindow swissprot:HSLJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HSLJ_ECOLI sigcleave swissprot:HSLJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HSLJ_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES pH dependence Optimum pH is 8.4.; # BRENDA 4.1.1.19 2026 # BioGrid 4262346 11 # CATALYTIC ACTIVITY SPEA_ECOLI L-arginine = agmatine + CO(2). # CDD cd06830 PLPDE_III_ADC # COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI 18420; # COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI 597326; # EcoGene EG10959 speA # FUNCTION SPEA_ECOLI Catalyzes the biosynthesis of agmatine from arginine. {ECO 0000250}. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_function GO:0008792 arginine decarboxylase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006527 arginine catabolic process; IDA:EcoCyc. # GO_process GO:0008295 spermidine biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0009446 putrescine biosynthetic process; IDA:EcoCyc. # GO_process GO:0033388 putrescine biosynthetic process from arginine; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 2.40.37.10 -; 2. # Gene3D 3.20.20.10 -; 1. # HAMAP MF_01417 SpeA # INDUCTION SPEA_ECOLI By growth in an acidic enriched medium containing arginine (biodegradative form), by growth in minimal media at neutral pH (biosynthetic). Putrescine and spermidine repress the speA gene and feedback inhibit ADC. # IntAct P21170 16 # InterPro IPR000183 Orn/DAP/Arg_de-COase # InterPro IPR002985 Arg_decrbxlase # InterPro IPR009006 Ala_racemase/Decarboxylase_C # InterPro IPR022643 De-COase2_C # InterPro IPR022644 De-COase2_N # InterPro IPR022653 De-COase2_pyr-phos_BS # InterPro IPR022657 De-COase2_CS # InterPro IPR029066 PLP-binding_barrel # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00330 Arginine and proline metabolism # MISCELLANEOUS ADC can be found in two forms biodegradative and biosynthetic. The biodegradative form may play a role in regulating pH by consuming proteins. # Organism SPEA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11482:SF36 PTHR11482:SF36; 2 # PATHWAY Amine and polyamine biosynthesis; agmatine biosynthesis; agmatine from L-arginine step 1/1. # PATRIC 32121288 VBIEscCol129921_3032 # PDB 3NZQ X-ray; 3.10 A; A/B=1-658 # PIR A65079 A65079 # PIRSF PIRSF001336 Arg_decrbxlase # PRINTS PR01179 ODADCRBXLASE # PRINTS PR01180 ARGDCRBXLASE # PROSITE PS00878 ODR_DC_2_1 # PROSITE PS00879 ODR_DC_2_2 # PTM SPEA_ECOLI Processed post-translationally to a 70 kDa mature form. # PTM SPEA_ECOLI The N-terminus is blocked. # Pfam PF00278 Orn_DAP_Arg_deC # Pfam PF02784 Orn_Arg_deC_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SPEA_ECOLI Biosynthetic arginine decarboxylase # RefSeq NP_417413 NC_000913.3 # RefSeq WP_001300904 NZ_LN832404.1 # SIMILARITY Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION SPEA_ECOLI Periplasm {ECO 0000269|PubMed 2198270}. # SUBUNIT SPEA_ECOLI Homotetramer. # SUPFAM SSF50621 SSF50621 # SUPFAM SSF51419 SSF51419 # TIGRFAMs TIGR01273 speA # UniPathway UPA00186 UER00284 # eggNOG COG1166 LUCA # eggNOG ENOG4105DP5 Bacteria BLAST swissprot:SPEA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SPEA_ECOLI BioCyc ECOL316407:JW2905-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2905-MONOMER BioCyc EcoCyc:ARGDECARBOXBIO-MONOMER http://biocyc.org/getid?id=EcoCyc:ARGDECARBOXBIO-MONOMER BioCyc MetaCyc:ARGDECARBOXBIO-MONOMER http://biocyc.org/getid?id=MetaCyc:ARGDECARBOXBIO-MONOMER COG COG1166 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1166 DIP DIP-10905N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10905N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.1.1.19 http://www.genome.jp/dbget-bin/www_bget?EC:4.1.1.19 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M31770 http://www.ebi.ac.uk/ena/data/view/M31770 EMBL M32363 http://www.ebi.ac.uk/ena/data/view/M32363 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 ENZYME 4.1.1.19 http://enzyme.expasy.org/EC/4.1.1.19 EchoBASE EB0952 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0952 EcoGene EG10959 http://www.ecogene.org/geneInfo.php?eg_id=EG10959 EnsemblBacteria AAC75975 http://www.ensemblgenomes.org/id/AAC75975 EnsemblBacteria AAC75975 http://www.ensemblgenomes.org/id/AAC75975 EnsemblBacteria BAE77001 http://www.ensemblgenomes.org/id/BAE77001 EnsemblBacteria BAE77001 http://www.ensemblgenomes.org/id/BAE77001 EnsemblBacteria BAE77001 http://www.ensemblgenomes.org/id/BAE77001 EnsemblBacteria b2938 http://www.ensemblgenomes.org/id/b2938 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0008792 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008792 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006527 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006527 GO_process GO:0008295 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008295 GO_process GO:0009446 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009446 GO_process GO:0033388 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033388 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 2.40.37.10 http://www.cathdb.info/version/latest/superfamily/2.40.37.10 Gene3D 3.20.20.10 http://www.cathdb.info/version/latest/superfamily/3.20.20.10 GeneID 947432 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947432 HAMAP MF_01417 http://hamap.expasy.org/unirule/MF_01417 HOGENOM HOG000029191 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000029191&db=HOGENOM6 InParanoid P21170 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P21170 IntAct P21170 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P21170* IntEnz 4.1.1.19 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.1.19 InterPro IPR000183 http://www.ebi.ac.uk/interpro/entry/IPR000183 InterPro IPR002985 http://www.ebi.ac.uk/interpro/entry/IPR002985 InterPro IPR009006 http://www.ebi.ac.uk/interpro/entry/IPR009006 InterPro IPR022643 http://www.ebi.ac.uk/interpro/entry/IPR022643 InterPro IPR022644 http://www.ebi.ac.uk/interpro/entry/IPR022644 InterPro IPR022653 http://www.ebi.ac.uk/interpro/entry/IPR022653 InterPro IPR022657 http://www.ebi.ac.uk/interpro/entry/IPR022657 InterPro IPR029066 http://www.ebi.ac.uk/interpro/entry/IPR029066 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2905 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2905 KEGG_Gene eco:b2938 http://www.genome.jp/dbget-bin/www_bget?eco:b2938 KEGG_Orthology KO:K01585 http://www.genome.jp/dbget-bin/www_bget?KO:K01585 KEGG_Pathway ko00330 http://www.genome.jp/kegg-bin/show_pathway?ko00330 KEGG_Reaction rn:R00566 http://www.genome.jp/dbget-bin/www_bget?rn:R00566 OMA DQLFPIM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DQLFPIM PANTHER PTHR11482:SF36 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11482:SF36 PDB 3NZQ http://www.ebi.ac.uk/pdbe-srv/view/entry/3NZQ PDBsum 3NZQ http://www.ebi.ac.uk/pdbsum/3NZQ PRINTS PR01179 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01179 PRINTS PR01180 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01180 PROSITE PS00878 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00878 PROSITE PS00879 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00879 PSORT swissprot:SPEA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SPEA_ECOLI PSORT-B swissprot:SPEA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SPEA_ECOLI PSORT2 swissprot:SPEA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SPEA_ECOLI Pfam PF00278 http://pfam.xfam.org/family/PF00278 Pfam PF02784 http://pfam.xfam.org/family/PF02784 Phobius swissprot:SPEA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SPEA_ECOLI PhylomeDB P21170 http://phylomedb.org/?seqid=P21170 ProteinModelPortal P21170 http://www.proteinmodelportal.org/query/uniprot/P21170 PubMed 1310091 http://www.ncbi.nlm.nih.gov/pubmed/1310091 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2198270 http://www.ncbi.nlm.nih.gov/pubmed/2198270 PubMed 4571773 http://www.ncbi.nlm.nih.gov/pubmed/4571773 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417413 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417413 RefSeq WP_001300904 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300904 SMR P21170 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P21170 STRING 511145.b2938 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2938&targetmode=cogs STRING COG1166 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1166&targetmode=cogs SUPFAM SSF50621 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50621 SUPFAM SSF51419 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51419 TIGRFAMs TIGR01273 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01273 UniProtKB SPEA_ECOLI http://www.uniprot.org/uniprot/SPEA_ECOLI UniProtKB-AC P21170 http://www.uniprot.org/uniprot/P21170 charge swissprot:SPEA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SPEA_ECOLI eggNOG COG1166 http://eggnogapi.embl.de/nog_data/html/tree/COG1166 eggNOG ENOG4105DP5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DP5 epestfind swissprot:SPEA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SPEA_ECOLI garnier swissprot:SPEA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SPEA_ECOLI helixturnhelix swissprot:SPEA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SPEA_ECOLI hmoment swissprot:SPEA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SPEA_ECOLI iep swissprot:SPEA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SPEA_ECOLI inforesidue swissprot:SPEA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SPEA_ECOLI octanol swissprot:SPEA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SPEA_ECOLI pepcoil swissprot:SPEA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SPEA_ECOLI pepdigest swissprot:SPEA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SPEA_ECOLI pepinfo swissprot:SPEA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SPEA_ECOLI pepnet swissprot:SPEA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SPEA_ECOLI pepstats swissprot:SPEA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SPEA_ECOLI pepwheel swissprot:SPEA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SPEA_ECOLI pepwindow swissprot:SPEA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SPEA_ECOLI sigcleave swissprot:SPEA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SPEA_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES GPH_ECOLI Kinetic parameters KM=210 uM for 2P-Gly {ECO 0000269|PubMed 13129953, ECO 0000269|PubMed 16990279}; KM=8.9 mM for acetyl-phosphate (with magnesium ions as cofactor and at pH 9) {ECO 0000269|PubMed 13129953, ECO 0000269|PubMed 16990279}; KM=0.13 mM for imido-diphosphate (with magnesium ions as cofactor and at pH 9) {ECO 0000269|PubMed 13129953, ECO 0000269|PubMed 16990279}; Vmax=208 umol/min/mg enzyme {ECO 0000269|PubMed 13129953, ECO 0000269|PubMed 16990279}; pH dependence Optimum pH is 6.9. {ECO 0000269|PubMed 13129953, ECO 0000269|PubMed 16990279}; # BioGrid 4259294 62 # CATALYTIC ACTIVITY 2-phosphoglycolate + H(2)O = glycolate + phosphate. {ECO:0000269|PubMed 10572959}. # COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI 18420; # COFACTOR Name=chloride; Xref=ChEBI:CHEBI 17996; # EcoGene EG11871 gph # FUNCTION GPH_ECOLI Specifically catalyzes the dephosphorylation of 2- phosphoglycolate (2P-Gly). Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. {ECO 0000269|PubMed 16990279}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0008967 phosphoglycolate phosphatase activity; IDA:EcoCyc. # GO_function GO:0031404 chloride ion binding; IDA:EcoCyc. # GO_process GO:0005975 carbohydrate metabolic process; IEA:UniProtKB-HAMAP. # GO_process GO:0006281 DNA repair; IMP:EcoCyc. # GO_process GO:0016311 dephosphorylation; IDA:EcoCyc. # GO_process GO:0046295 glycolate biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.150.240 -; 1. # Gene3D 3.40.50.1000 -; 1. # HAMAP MF_00495 GPH_hydrolase_bact # INDUCTION Constitutively expressed. {ECO:0000269|PubMed 13129953}. # IntAct P32662 13 # InterPro IPR006346 PGP_bact # InterPro IPR006439 HAD-SF_hydro_IA # InterPro IPR023198 PGP_dom2 # InterPro IPR023214 HAD-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00630 Glyoxylate and dicarboxylate metabolism # Organism GPH_ECOLI Escherichia coli (strain K12) # PATHWAY Organic acid metabolism; glycolate biosynthesis; glycolate from 2-phosphoglycolate step 1/1. # PATRIC 32122202 VBIEscCol129921_3478 # PIR S55288 S55288 # PRINTS PR00413 HADHALOGNASE # Pfam PF13419 HAD_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GPH_ECOLI Phosphoglycolate phosphatase # RefSeq NP_417844 NC_000913.3 # RefSeq WP_001031729 NZ_LN832404.1 # SIMILARITY Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. {ECO 0000305}. # SUBUNIT Monomer. {ECO:0000269|PubMed 13129953}. # SUPFAM SSF56784 SSF56784 # TIGRFAMs TIGR01449 PGP_bact # TIGRFAMs TIGR01509 HAD-SF-IA-v3 # TIGRFAMs TIGR01549 HAD-SF-IA-v1 # UniPathway UPA00865 UER00834 # eggNOG COG0546 LUCA # eggNOG ENOG4108VXP Bacteria BLAST swissprot:GPH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GPH_ECOLI BioCyc ECOL316407:JW3348-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3348-MONOMER BioCyc EcoCyc:GPH-MONOMER http://biocyc.org/getid?id=EcoCyc:GPH-MONOMER BioCyc MetaCyc:GPH-MONOMER http://biocyc.org/getid?id=MetaCyc:GPH-MONOMER COG COG0546 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0546 DOI 10.1007/BF00290345 http://dx.doi.org/10.1007/BF00290345 DOI 10.1016/S0304-4165(99)00146-4 http://dx.doi.org/10.1016/S0304-4165(99)00146-4 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M605449200 http://dx.doi.org/10.1074/jbc.M605449200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.185.19.5815-5821.2003 http://dx.doi.org/10.1128/JB.185.19.5815-5821.2003 EC_number EC:3.1.3.18 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.18 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL Z19601 http://www.ebi.ac.uk/ena/data/view/Z19601 ENZYME 3.1.3.18 http://enzyme.expasy.org/EC/3.1.3.18 EchoBASE EB1817 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1817 EcoGene EG11871 http://www.ecogene.org/geneInfo.php?eg_id=EG11871 EnsemblBacteria AAC76410 http://www.ensemblgenomes.org/id/AAC76410 EnsemblBacteria AAC76410 http://www.ensemblgenomes.org/id/AAC76410 EnsemblBacteria BAE77906 http://www.ensemblgenomes.org/id/BAE77906 EnsemblBacteria BAE77906 http://www.ensemblgenomes.org/id/BAE77906 EnsemblBacteria BAE77906 http://www.ensemblgenomes.org/id/BAE77906 EnsemblBacteria b3385 http://www.ensemblgenomes.org/id/b3385 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0008967 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008967 GO_function GO:0031404 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031404 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GO_process GO:0006281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006281 GO_process GO:0016311 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016311 GO_process GO:0046295 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046295 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.150.240 http://www.cathdb.info/version/latest/superfamily/1.10.150.240 Gene3D 3.40.50.1000 http://www.cathdb.info/version/latest/superfamily/3.40.50.1000 GeneID 947895 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947895 HAMAP MF_00495 http://hamap.expasy.org/unirule/MF_00495 HOGENOM HOG000248344 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000248344&db=HOGENOM6 InParanoid P32662 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32662 IntAct P32662 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32662* IntEnz 3.1.3.18 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.18 InterPro IPR006346 http://www.ebi.ac.uk/interpro/entry/IPR006346 InterPro IPR006439 http://www.ebi.ac.uk/interpro/entry/IPR006439 InterPro IPR023198 http://www.ebi.ac.uk/interpro/entry/IPR023198 InterPro IPR023214 http://www.ebi.ac.uk/interpro/entry/IPR023214 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3348 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3348 KEGG_Gene eco:b3385 http://www.genome.jp/dbget-bin/www_bget?eco:b3385 KEGG_Orthology KO:K01091 http://www.genome.jp/dbget-bin/www_bget?KO:K01091 KEGG_Pathway ko00630 http://www.genome.jp/kegg-bin/show_pathway?ko00630 KEGG_Reaction rn:R01334 http://www.genome.jp/dbget-bin/www_bget?rn:R01334 OMA HPAPLFL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HPAPLFL PRINTS PR00413 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00413 PSORT swissprot:GPH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GPH_ECOLI PSORT-B swissprot:GPH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GPH_ECOLI PSORT2 swissprot:GPH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GPH_ECOLI Pfam PF13419 http://pfam.xfam.org/family/PF13419 Phobius swissprot:GPH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GPH_ECOLI PhylomeDB P32662 http://phylomedb.org/?seqid=P32662 ProteinModelPortal P32662 http://www.proteinmodelportal.org/query/uniprot/P32662 PubMed 10572959 http://www.ncbi.nlm.nih.gov/pubmed/10572959 PubMed 13129953 http://www.ncbi.nlm.nih.gov/pubmed/13129953 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16990279 http://www.ncbi.nlm.nih.gov/pubmed/16990279 PubMed 7603433 http://www.ncbi.nlm.nih.gov/pubmed/7603433 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417844 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417844 RefSeq WP_001031729 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001031729 SMR P32662 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32662 STRING 511145.b3385 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3385&targetmode=cogs STRING COG0546 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0546&targetmode=cogs SUPFAM SSF56784 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784 SWISS-2DPAGE P32662 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P32662 TIGRFAMs TIGR01449 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01449 TIGRFAMs TIGR01509 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01509 TIGRFAMs TIGR01549 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01549 UniProtKB GPH_ECOLI http://www.uniprot.org/uniprot/GPH_ECOLI UniProtKB-AC P32662 http://www.uniprot.org/uniprot/P32662 charge swissprot:GPH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GPH_ECOLI eggNOG COG0546 http://eggnogapi.embl.de/nog_data/html/tree/COG0546 eggNOG ENOG4108VXP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108VXP epestfind swissprot:GPH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GPH_ECOLI garnier swissprot:GPH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GPH_ECOLI helixturnhelix swissprot:GPH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GPH_ECOLI hmoment swissprot:GPH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GPH_ECOLI iep swissprot:GPH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GPH_ECOLI inforesidue swissprot:GPH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GPH_ECOLI octanol swissprot:GPH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GPH_ECOLI pepcoil swissprot:GPH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GPH_ECOLI pepdigest swissprot:GPH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GPH_ECOLI pepinfo swissprot:GPH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GPH_ECOLI pepnet swissprot:GPH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GPH_ECOLI pepstats swissprot:GPH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GPH_ECOLI pepwheel swissprot:GPH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GPH_ECOLI pepwindow swissprot:GPH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GPH_ECOLI sigcleave swissprot:GPH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GPH_ECOLI ## Database ID URL or Descriptions # AltName NARI_ECOLI Cytochrome B-NR # AltName NARI_ECOLI Nitrate reductase A subunit gamma # AltName NARI_ECOLI Quinol-nitrate oxidoreductase subunit gamma # BRENDA 1.7.5 2026 # BioGrid 4262233 10 # CATALYTIC ACTIVITY NARI_ECOLI Nitrite + acceptor = nitrate + reduced acceptor. # COFACTOR NARI_ECOLI Name=heme; Xref=ChEBI CHEBI 30413; Evidence={ECO 0000269|PubMed 12910261}; Note=Binds 2 heme groups per subunit. Heme 1, called the proximal or heme Bp in PubMed 12910261, is located at the cytoplasmic interface, heme 2, called the distal or heme Bd, is located at the periplasmic interface. Electrons are transferred from the periplasmic to the cytoplasmic heme. {ECO 0000269|PubMed 12910261}; # EcoGene EG10640 narI # FUNCTION NARI_ECOLI The nitrate reductase enzyme complex allows E.coli to use nitrate as an electron acceptor during anaerobic growth. The gamma chain is a membrane-embedded heme-iron unit resembling cytochrome b, which transfers electrons from quinones to the beta subunit. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0009325 nitrate reductase complex; IDA:CACAO. # GO_component GO:0044799 NarGHI complex; IDA:EcoCyc. # GO_function GO:0008940 nitrate reductase activity; IDA:EcoCyc. # GO_function GO:0009055 electron carrier activity; IDA:EcoCyc. # GO_function GO:0020037 heme binding; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0009061 anaerobic respiration; IEP:EcoCyc. # GO_process GO:0019645 anaerobic electron transport chain; IBA:GO_Central. # GO_process GO:0042128 nitrate assimilation; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0071941 nitrogen cycle metabolic process # INDUCTION NARI_ECOLI By nitrate. # IntAct P11350 2 # InterPro IPR003816 Nitrate_red_gam # InterPro IPR023234 NarG-like_domain # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00910 Nitrogen metabolism # KEGG_Pathway ko02020 Two-component system # Organism NARI_ECOLI Escherichia coli (strain K12) # PATRIC 32117714 VBIEscCol129921_1279 # PDB 1Q16 X-ray; 1.90 A; C=1-225 # PDB 1SIW X-ray; 2.20 A; C=1-225 # PDB 1Y4Z X-ray; 2.00 A; C=1-225 # PDB 1Y5I X-ray; 1.90 A; C=1-225 # PDB 1Y5L X-ray; 2.50 A; C=1-225 # PDB 1Y5N X-ray; 2.50 A; C=1-225 # PDB 3EGW X-ray; 1.90 A; C=1-225 # PDB 3IR5 X-ray; 2.30 A; C=1-225 # PDB 3IR6 X-ray; 2.80 A; C=1-225 # PDB 3IR7 X-ray; 2.50 A; C=1-225 # PIR C27737 RDECNG # Pfam PF02665 Nitrate_red_gam # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NARI_ECOLI Respiratory nitrate reductase 1 gamma chain # RefSeq NP_415745 NC_000913.3 # RefSeq WP_001160108 NZ_LN832404.1 # SUBCELLULAR LOCATION NARI_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT Dimer of heterotrimers each composed of an alpha, a beta and a gamma chain. Alpha and beta are catalytic chains; gamma chains are involved in binding the enzyme complex to the cytoplasmic membrane. {ECO:0000269|PubMed 12910261}. # SUPFAM SSF103501 SSF103501 # TCDB 5.A.3.1 the prokaryotic molybdopterin-containing oxidoreductase (pmo) family # TIGRFAMs TIGR00351 narI # WEB RESOURCE NARI_ECOLI Name=Worthington enzyme manual; URL="http //www.worthington-biochem.com/NAR/"; # eggNOG COG2181 LUCA # eggNOG ENOG41076YT Bacteria BLAST swissprot:NARI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NARI_ECOLI BioCyc ECOL316407:JW1218-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1218-MONOMER BioCyc EcoCyc:NARI-MONOMER http://biocyc.org/getid?id=EcoCyc:NARI-MONOMER BioCyc MetaCyc:NARI-MONOMER http://biocyc.org/getid?id=MetaCyc:NARI-MONOMER COG COG2181 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2181 DIP DIP-10313N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10313N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb969 http://dx.doi.org/10.1038/nsb969 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.7.99.4 http://www.genome.jp/dbget-bin/www_bget?EC:1.7.99.4 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M20147 http://www.ebi.ac.uk/ena/data/view/M20147 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.7.99.4 http://enzyme.expasy.org/EC/1.7.99.4 EchoBASE EB0634 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0634 EcoGene EG10640 http://www.ecogene.org/geneInfo.php?eg_id=EG10640 EnsemblBacteria AAC74311 http://www.ensemblgenomes.org/id/AAC74311 EnsemblBacteria AAC74311 http://www.ensemblgenomes.org/id/AAC74311 EnsemblBacteria BAA36097 http://www.ensemblgenomes.org/id/BAA36097 EnsemblBacteria BAA36097 http://www.ensemblgenomes.org/id/BAA36097 EnsemblBacteria BAA36097 http://www.ensemblgenomes.org/id/BAA36097 EnsemblBacteria b1227 http://www.ensemblgenomes.org/id/b1227 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0009325 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009325 GO_component GO:0044799 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044799 GO_function GO:0008940 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008940 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0020037 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0020037 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0009061 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009061 GO_process GO:0019645 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019645 GO_process GO:0042128 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042128 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0071941 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071941 GeneID 945808 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945808 HOGENOM HOG000237376 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000237376&db=HOGENOM6 InParanoid P11350 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P11350 IntAct P11350 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P11350* IntEnz 1.7.99.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.7.99.4 InterPro IPR003816 http://www.ebi.ac.uk/interpro/entry/IPR003816 InterPro IPR023234 http://www.ebi.ac.uk/interpro/entry/IPR023234 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1218 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1218 KEGG_Gene eco:b1227 http://www.genome.jp/dbget-bin/www_bget?eco:b1227 KEGG_Orthology KO:K00374 http://www.genome.jp/dbget-bin/www_bget?KO:K00374 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 KEGG_Reaction rn:R00798 http://www.genome.jp/dbget-bin/www_bget?rn:R00798 KEGG_Reaction rn:R01106 http://www.genome.jp/dbget-bin/www_bget?rn:R01106 MINT MINT-1262739 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1262739 OMA DIMILTL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DIMILTL PDB 1Q16 http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q16 PDB 1SIW http://www.ebi.ac.uk/pdbe-srv/view/entry/1SIW PDB 1Y4Z http://www.ebi.ac.uk/pdbe-srv/view/entry/1Y4Z PDB 1Y5I http://www.ebi.ac.uk/pdbe-srv/view/entry/1Y5I PDB 1Y5L http://www.ebi.ac.uk/pdbe-srv/view/entry/1Y5L PDB 1Y5N http://www.ebi.ac.uk/pdbe-srv/view/entry/1Y5N PDB 3EGW http://www.ebi.ac.uk/pdbe-srv/view/entry/3EGW PDB 3IR5 http://www.ebi.ac.uk/pdbe-srv/view/entry/3IR5 PDB 3IR6 http://www.ebi.ac.uk/pdbe-srv/view/entry/3IR6 PDB 3IR7 http://www.ebi.ac.uk/pdbe-srv/view/entry/3IR7 PDBsum 1Q16 http://www.ebi.ac.uk/pdbsum/1Q16 PDBsum 1SIW http://www.ebi.ac.uk/pdbsum/1SIW PDBsum 1Y4Z http://www.ebi.ac.uk/pdbsum/1Y4Z PDBsum 1Y5I http://www.ebi.ac.uk/pdbsum/1Y5I PDBsum 1Y5L http://www.ebi.ac.uk/pdbsum/1Y5L PDBsum 1Y5N http://www.ebi.ac.uk/pdbsum/1Y5N PDBsum 3EGW http://www.ebi.ac.uk/pdbsum/3EGW PDBsum 3IR5 http://www.ebi.ac.uk/pdbsum/3IR5 PDBsum 3IR6 http://www.ebi.ac.uk/pdbsum/3IR6 PDBsum 3IR7 http://www.ebi.ac.uk/pdbsum/3IR7 PSORT swissprot:NARI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NARI_ECOLI PSORT-B swissprot:NARI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NARI_ECOLI PSORT2 swissprot:NARI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NARI_ECOLI Pfam PF02665 http://pfam.xfam.org/family/PF02665 Phobius swissprot:NARI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NARI_ECOLI PhylomeDB P11350 http://phylomedb.org/?seqid=P11350 ProteinModelPortal P11350 http://www.proteinmodelportal.org/query/uniprot/P11350 PubMed 12910261 http://www.ncbi.nlm.nih.gov/pubmed/12910261 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2832376 http://www.ncbi.nlm.nih.gov/pubmed/2832376 PubMed 3053688 http://www.ncbi.nlm.nih.gov/pubmed/3053688 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415745 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415745 RefSeq WP_001160108 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001160108 SMR P11350 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P11350 STRING 511145.b1227 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1227&targetmode=cogs STRING COG2181 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2181&targetmode=cogs SUPFAM SSF103501 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103501 TCDB 5.A.3.1 http://www.tcdb.org/search/result.php?tc=5.A.3.1 TIGRFAMs TIGR00351 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00351 UniProtKB NARI_ECOLI http://www.uniprot.org/uniprot/NARI_ECOLI UniProtKB-AC P11350 http://www.uniprot.org/uniprot/P11350 charge swissprot:NARI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NARI_ECOLI eggNOG COG2181 http://eggnogapi.embl.de/nog_data/html/tree/COG2181 eggNOG ENOG41076YT http://eggnogapi.embl.de/nog_data/html/tree/ENOG41076YT epestfind swissprot:NARI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NARI_ECOLI garnier swissprot:NARI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NARI_ECOLI helixturnhelix swissprot:NARI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NARI_ECOLI hmoment swissprot:NARI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NARI_ECOLI iep swissprot:NARI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NARI_ECOLI inforesidue swissprot:NARI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NARI_ECOLI octanol swissprot:NARI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NARI_ECOLI pepcoil swissprot:NARI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NARI_ECOLI pepdigest swissprot:NARI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NARI_ECOLI pepinfo swissprot:NARI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NARI_ECOLI pepnet swissprot:NARI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NARI_ECOLI pepstats swissprot:NARI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NARI_ECOLI pepwheel swissprot:NARI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NARI_ECOLI pepwindow swissprot:NARI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NARI_ECOLI sigcleave swissprot:NARI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NARI_ECOLI ## Database ID URL or Descriptions # CAUTION MntS mRNA was originally thought to be an sRNA. {ECO 0000305}. # EcoGene EG14500 mntS # FUNCTION MNTS_ECOLI Required for repression of mntH by MntR. May function as a chaperone that makes manganese more available by delivering it to the necessary cellular locations when manganese is limiting. {ECO 0000269|PubMed 21908668}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_process GO:0030026 cellular manganese ion homeostasis; IMP:EcoCyc. # GO_process GO:0071287 cellular response to manganese ion; IEP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_process GO:0008150 biological_process # GOslim_process GO:0042592 homeostatic process # INDUCTION Repressed by MntR in response to manganese. {ECO:0000269|PubMed 21908668}. # Organism MNTS_ECOLI Escherichia coli (strain K12) # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MNTS_ECOLI Small protein MntS # RefSeq WP_001001761 NZ_LN832404.1 # RefSeq YP_009029995 NC_000913.3 # SUBCELLULAR LOCATION MNTS_ECOLI Cytoplasm {ECO 0000269|PubMed 21778229}. Note=May be loosely associated with the inner membrane. BLAST swissprot:MNTS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MNTS_ECOLI BioCyc EcoCyc:MONOMER0-4216 http://biocyc.org/getid?id=EcoCyc:MONOMER0-4216 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M111.245696 http://dx.doi.org/10.1074/jbc.M111.245696 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.05872-11 http://dx.doi.org/10.1128/JB.05872-11 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14500 http://www.ecogene.org/geneInfo.php?eg_id=EG14500 EnsemblBacteria AHA50631 http://www.ensemblgenomes.org/id/AHA50631 EnsemblBacteria AHA50631 http://www.ensemblgenomes.org/id/AHA50631 EnsemblBacteria b4705 http://www.ensemblgenomes.org/id/b4705 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_process GO:0030026 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030026 GO_process GO:0071287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071287 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GeneID 14678509 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14678509 KEGG_Gene eco:b4705 http://www.genome.jp/dbget-bin/www_bget?eco:b4705 PSORT swissprot:MNTS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MNTS_ECOLI PSORT-B swissprot:MNTS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MNTS_ECOLI PSORT2 swissprot:MNTS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MNTS_ECOLI Phobius swissprot:MNTS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MNTS_ECOLI ProteinModelPortal P0DKB3 http://www.proteinmodelportal.org/query/uniprot/P0DKB3 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21778229 http://www.ncbi.nlm.nih.gov/pubmed/21778229 PubMed 21908668 http://www.ncbi.nlm.nih.gov/pubmed/21908668 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001001761 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001001761 RefSeq YP_009029995 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009029995 SMR P0DKB3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0DKB3 UniProtKB MNTS_ECOLI http://www.uniprot.org/uniprot/MNTS_ECOLI UniProtKB-AC P0DKB3 http://www.uniprot.org/uniprot/P0DKB3 charge swissprot:MNTS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MNTS_ECOLI epestfind swissprot:MNTS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MNTS_ECOLI garnier swissprot:MNTS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MNTS_ECOLI helixturnhelix swissprot:MNTS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MNTS_ECOLI hmoment swissprot:MNTS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MNTS_ECOLI iep swissprot:MNTS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MNTS_ECOLI inforesidue swissprot:MNTS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MNTS_ECOLI octanol swissprot:MNTS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MNTS_ECOLI pepcoil swissprot:MNTS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MNTS_ECOLI pepdigest swissprot:MNTS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MNTS_ECOLI pepinfo swissprot:MNTS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MNTS_ECOLI pepnet swissprot:MNTS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MNTS_ECOLI pepstats swissprot:MNTS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MNTS_ECOLI pepwheel swissprot:MNTS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MNTS_ECOLI pepwindow swissprot:MNTS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MNTS_ECOLI sigcleave swissprot:MNTS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MNTS_ECOLI ## Database ID URL or Descriptions # AltName HYCI_ECOLI HycI protease # BRENDA 3.4.23.51 2026 # BioGrid 4261309 13 # CATALYTIC ACTIVITY HYCI_ECOLI This enzyme specifically removes a 32-amino acid peptide from the C-terminus of the precursor of the large subunit of E.coli hydrogenase 3 by cleavage at the C-terminal side of Arg(537). # CDD cd06067 H2MP_MemB-H2evol # EcoGene EG13396 hycI # FUNCTION HYCI_ECOLI Protease involved in the C-terminal processing of HycE, the large subunit of hydrogenase 3. # GO_function GO:0004175 endopeptidase activity; IDA:EcoCyc. # GO_function GO:0004190 aspartic-type endopeptidase activity; IEA:UniProtKB-KW. # GO_function GO:0008047 enzyme activator activity; IEA:InterPro. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0016485 protein processing; IBA:GO_Central. # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0030234 enzyme regulator activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0051604 protein maturation # Gene3D 3.40.50.1450 -; 1. # IntAct P0AEV9 9 # InterPro IPR000671 Peptidase_A31 # InterPro IPR004420 Pept_A31_hyd_mat_HycI # InterPro IPR023430 Pept_HybD-like_dom # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # Organism HYCI_ECOLI Escherichia coli (strain K12) # PATRIC 32120834 VBIEscCol129921_2809 # PDB 2E85 X-ray; 1.70 A; A/B=1-156 # PDB 2I8L NMR; -; A=1-156 # PIR S67469 S67469 # PRINTS PR00446 HYDRGNUPTAKE # Pfam PF01750 HycI # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HYCI_ECOLI Hydrogenase 3 maturation protease # RefSeq NP_417197 NC_000913.3 # RefSeq WP_000132961 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase A31 family. {ECO 0000305}. # SUBUNIT Monomer. {ECO:0000269|PubMed 19720045}. # SUPFAM SSF53163 SSF53163 # TIGRFAMs TIGR00072 hydrog_prot # TIGRFAMs TIGR00142 hycI # eggNOG COG0680 LUCA # eggNOG ENOG4108MG9 Bacteria BLAST swissprot:HYCI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HYCI_ECOLI BioCyc ECOL316407:JW2687-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2687-MONOMER BioCyc EcoCyc:G7414-MONOMER http://biocyc.org/getid?id=EcoCyc:G7414-MONOMER BioCyc MetaCyc:G7414-MONOMER http://biocyc.org/getid?id=MetaCyc:G7414-MONOMER COG COG0680 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0680 DIP DIP-48019N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48019N DOI 10.1016/j.bbrc.2009.08.135 http://dx.doi.org/10.1016/j.bbrc.2009.08.135 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1432-1327.2000.01202.x http://dx.doi.org/10.1046/j.1432-1327.2000.01202.x DOI 10.1074/jbc.M609263200 http://dx.doi.org/10.1074/jbc.M609263200 DOI 10.1111/j.1432-1033.1995.tb20422.x http://dx.doi.org/10.1111/j.1432-1033.1995.tb20422.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.23.51 http://www.genome.jp/dbget-bin/www_bget?EC:3.4.23.51 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EMBL X17506 http://www.ebi.ac.uk/ena/data/view/X17506 ENZYME 3.4.23.51 http://enzyme.expasy.org/EC/3.4.23.51 EchoBASE EB3177 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3177 EcoGene EG13396 http://www.ecogene.org/geneInfo.php?eg_id=EG13396 EnsemblBacteria AAC75759 http://www.ensemblgenomes.org/id/AAC75759 EnsemblBacteria AAC75759 http://www.ensemblgenomes.org/id/AAC75759 EnsemblBacteria BAE76794 http://www.ensemblgenomes.org/id/BAE76794 EnsemblBacteria BAE76794 http://www.ensemblgenomes.org/id/BAE76794 EnsemblBacteria BAE76794 http://www.ensemblgenomes.org/id/BAE76794 EnsemblBacteria b2717 http://www.ensemblgenomes.org/id/b2717 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004175 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004175 GO_function GO:0004190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004190 GO_function GO:0008047 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008047 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0016485 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016485 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 Gene3D 3.40.50.1450 http://www.cathdb.info/version/latest/superfamily/3.40.50.1450 GeneID 947428 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947428 HOGENOM HOG000278720 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278720&db=HOGENOM6 InParanoid P0AEV9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEV9 IntAct P0AEV9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEV9* IntEnz 3.4.23.51 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.23.51 InterPro IPR000671 http://www.ebi.ac.uk/interpro/entry/IPR000671 InterPro IPR004420 http://www.ebi.ac.uk/interpro/entry/IPR004420 InterPro IPR023430 http://www.ebi.ac.uk/interpro/entry/IPR023430 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW2687 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2687 KEGG_Gene eco:b2717 http://www.genome.jp/dbget-bin/www_bget?eco:b2717 KEGG_Orthology KO:K08315 http://www.genome.jp/dbget-bin/www_bget?KO:K08315 MINT MINT-1244231 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1244231 OMA VAFYFPI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VAFYFPI PDB 2E85 http://www.ebi.ac.uk/pdbe-srv/view/entry/2E85 PDB 2I8L http://www.ebi.ac.uk/pdbe-srv/view/entry/2I8L PDBsum 2E85 http://www.ebi.ac.uk/pdbsum/2E85 PDBsum 2I8L http://www.ebi.ac.uk/pdbsum/2I8L PRINTS PR00446 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00446 PSORT swissprot:HYCI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HYCI_ECOLI PSORT-B swissprot:HYCI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HYCI_ECOLI PSORT2 swissprot:HYCI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HYCI_ECOLI Pfam PF01750 http://pfam.xfam.org/family/PF01750 Phobius swissprot:HYCI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HYCI_ECOLI PhylomeDB P0AEV9 http://phylomedb.org/?seqid=P0AEV9 ProteinModelPortal P0AEV9 http://www.proteinmodelportal.org/query/uniprot/P0AEV9 PubMed 10727938 http://www.ncbi.nlm.nih.gov/pubmed/10727938 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17150961 http://www.ncbi.nlm.nih.gov/pubmed/17150961 PubMed 19720045 http://www.ncbi.nlm.nih.gov/pubmed/19720045 PubMed 7851435 http://www.ncbi.nlm.nih.gov/pubmed/7851435 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417197 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417197 RefSeq WP_000132961 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000132961 SMR P0AEV9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEV9 STRING 511145.b2717 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2717&targetmode=cogs STRING COG0680 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0680&targetmode=cogs SUPFAM SSF53163 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53163 TIGRFAMs TIGR00072 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00072 TIGRFAMs TIGR00142 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00142 UniProtKB HYCI_ECOLI http://www.uniprot.org/uniprot/HYCI_ECOLI UniProtKB-AC P0AEV9 http://www.uniprot.org/uniprot/P0AEV9 charge swissprot:HYCI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HYCI_ECOLI eggNOG COG0680 http://eggnogapi.embl.de/nog_data/html/tree/COG0680 eggNOG ENOG4108MG9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MG9 epestfind swissprot:HYCI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HYCI_ECOLI garnier swissprot:HYCI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HYCI_ECOLI helixturnhelix swissprot:HYCI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HYCI_ECOLI hmoment swissprot:HYCI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HYCI_ECOLI iep swissprot:HYCI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HYCI_ECOLI inforesidue swissprot:HYCI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HYCI_ECOLI octanol swissprot:HYCI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HYCI_ECOLI pepcoil swissprot:HYCI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HYCI_ECOLI pepdigest swissprot:HYCI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HYCI_ECOLI pepinfo swissprot:HYCI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HYCI_ECOLI pepnet swissprot:HYCI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HYCI_ECOLI pepstats swissprot:HYCI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HYCI_ECOLI pepwheel swissprot:HYCI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HYCI_ECOLI pepwindow swissprot:HYCI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HYCI_ECOLI sigcleave swissprot:HYCI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HYCI_ECOLI ## Database ID URL or Descriptions # BioGrid 4262648 241 # EcoGene EG11878 yiiU # FUNCTION ZAPB_ECOLI Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA. {ECO 0000269|PubMed 18394147}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0032153 cell division site; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0043093 FtsZ-dependent cytokinesis; IMP:EcoCyc. # GO_process GO:0090529 cell septum assembly; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0008150 biological_process # GOslim_process GO:0022607 cellular component assembly # HAMAP MF_01196 ZapB # INTERACTION ZAPB_ECOLI P0ADS2 zapA; NbExp=4; IntAct=EBI-1134093, EBI-1119901; # IntAct P0AF36 4 # InterPro IPR009252 Cell_div_ZapB # Organism ZAPB_ECOLI Escherichia coli (strain K12) # PATRIC 32123371 VBIEscCol129921_4046 # PDB 2JEE X-ray; 2.80 A; A/B/C/D=1-81 # PIR S40871 S40871 # Pfam PF06005 ZapB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ZAPB_ECOLI Cell division protein ZapB # RefSeq NP_418363 NC_000913.3 # SIMILARITY Belongs to the ZapB family. {ECO 0000305}. # SUBCELLULAR LOCATION ZAPB_ECOLI Cytoplasm {ECO 0000269|PubMed 18394147}. Note=Localizes to the septum at mid-cell, in a FtsZ-like pattern. # SUBUNIT Homodimer. The ends of the coiled-coil dimer bind to each other, forming polymers. Interacts with FtsZ. {ECO:0000269|PubMed 18394147}. # eggNOG COG3074 LUCA # eggNOG ENOG4105N4M Bacteria BLAST swissprot:ZAPB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ZAPB_ECOLI BioCyc ECOL316407:JW3899-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3899-MONOMER BioCyc EcoCyc:EG11878-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11878-MONOMER COG COG3074 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3074 DIP DIP-35850N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35850N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1111/j.1365-2958.2008.06190.x http://dx.doi.org/10.1111/j.1365-2958.2008.06190.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1824 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1824 EcoGene EG11878 http://www.ecogene.org/geneInfo.php?eg_id=EG11878 EnsemblBacteria AAC76910 http://www.ensemblgenomes.org/id/AAC76910 EnsemblBacteria AAC76910 http://www.ensemblgenomes.org/id/AAC76910 EnsemblBacteria BAE77382 http://www.ensemblgenomes.org/id/BAE77382 EnsemblBacteria BAE77382 http://www.ensemblgenomes.org/id/BAE77382 EnsemblBacteria BAE77382 http://www.ensemblgenomes.org/id/BAE77382 EnsemblBacteria b3928 http://www.ensemblgenomes.org/id/b3928 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0032153 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032153 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0043093 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043093 GO_process GO:0090529 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090529 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GeneID 948420 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948420 HAMAP MF_01196 http://hamap.expasy.org/unirule/MF_01196 HOGENOM HOG000218436 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218436&db=HOGENOM6 IntAct P0AF36 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AF36* InterPro IPR009252 http://www.ebi.ac.uk/interpro/entry/IPR009252 KEGG_Gene ecj:JW3899 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3899 KEGG_Gene eco:b3928 http://www.genome.jp/dbget-bin/www_bget?eco:b3928 KEGG_Orthology KO:K09892 http://www.genome.jp/dbget-bin/www_bget?KO:K09892 OMA GKMEDVQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GKMEDVQ PDB 2JEE http://www.ebi.ac.uk/pdbe-srv/view/entry/2JEE PDBsum 2JEE http://www.ebi.ac.uk/pdbsum/2JEE PSORT swissprot:ZAPB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ZAPB_ECOLI PSORT-B swissprot:ZAPB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ZAPB_ECOLI PSORT2 swissprot:ZAPB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ZAPB_ECOLI Pfam PF06005 http://pfam.xfam.org/family/PF06005 Phobius swissprot:ZAPB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ZAPB_ECOLI ProteinModelPortal P0AF36 http://www.proteinmodelportal.org/query/uniprot/P0AF36 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18394147 http://www.ncbi.nlm.nih.gov/pubmed/18394147 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418363 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418363 SMR P0AF36 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AF36 STRING 511145.b3928 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3928&targetmode=cogs STRING COG3074 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3074&targetmode=cogs UniProtKB ZAPB_ECOLI http://www.uniprot.org/uniprot/ZAPB_ECOLI UniProtKB-AC P0AF36 http://www.uniprot.org/uniprot/P0AF36 charge swissprot:ZAPB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ZAPB_ECOLI eggNOG COG3074 http://eggnogapi.embl.de/nog_data/html/tree/COG3074 eggNOG ENOG4105N4M http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105N4M epestfind swissprot:ZAPB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ZAPB_ECOLI garnier swissprot:ZAPB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ZAPB_ECOLI helixturnhelix swissprot:ZAPB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ZAPB_ECOLI hmoment swissprot:ZAPB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ZAPB_ECOLI iep swissprot:ZAPB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ZAPB_ECOLI inforesidue swissprot:ZAPB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ZAPB_ECOLI octanol swissprot:ZAPB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ZAPB_ECOLI pepcoil swissprot:ZAPB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ZAPB_ECOLI pepdigest swissprot:ZAPB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ZAPB_ECOLI pepinfo swissprot:ZAPB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ZAPB_ECOLI pepnet swissprot:ZAPB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ZAPB_ECOLI pepstats swissprot:ZAPB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ZAPB_ECOLI pepwheel swissprot:ZAPB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ZAPB_ECOLI pepwindow swissprot:ZAPB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ZAPB_ECOLI sigcleave swissprot:ZAPB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ZAPB_ECOLI ## Database ID URL or Descriptions # BioGrid 4262032 65 # EcoGene EG13250 ybaV # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_process GO:0006281 DNA repair; IEA:InterPro. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # InterPro IPR003583 Hlx-hairpin-Hlx_DNA-bd_motif # InterPro IPR004509 Competence_ComEA_HhH # InterPro IPR010994 RuvA_2-like # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02044 M00429 Competence-related DNA transformation transporter # KEGG_Brite ko02044 Secretion system # Organism YBAV_ECOLI Escherichia coli (strain K12) # PATRIC 32116037 VBIEscCol129921_0460 # PIR B64774 B64774 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBAV_ECOLI Uncharacterized protein YbaV # RefSeq NP_414976 NC_000913.3 # RefSeq WP_000680312 NZ_LN832404.1 # SIMILARITY Contains 2 HhH domains. {ECO 0000305}. # SMART SM00278 HhH1; 2 # SUPFAM SSF47781 SSF47781 # TIGRFAMs TIGR00426 TIGR00426 # eggNOG COG1555 LUCA # eggNOG ENOG41083P1 Bacteria BLAST swissprot:YBAV_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBAV_ECOLI BioCyc ECOL316407:JW0432-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0432-MONOMER BioCyc EcoCyc:G6243-MONOMER http://biocyc.org/getid?id=EcoCyc:G6243-MONOMER COG COG1555 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1555 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D82943 http://www.ebi.ac.uk/ena/data/view/D82943 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EchoBASE EB3039 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3039 EcoGene EG13250 http://www.ecogene.org/geneInfo.php?eg_id=EG13250 EnsemblBacteria AAC73545 http://www.ensemblgenomes.org/id/AAC73545 EnsemblBacteria AAC73545 http://www.ensemblgenomes.org/id/AAC73545 EnsemblBacteria BAE76222 http://www.ensemblgenomes.org/id/BAE76222 EnsemblBacteria BAE76222 http://www.ensemblgenomes.org/id/BAE76222 EnsemblBacteria BAE76222 http://www.ensemblgenomes.org/id/BAE76222 EnsemblBacteria b0442 http://www.ensemblgenomes.org/id/b0442 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006281 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 945884 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945884 HOGENOM HOG000257817 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000257817&db=HOGENOM6 InParanoid P0AAR8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAR8 InterPro IPR003583 http://www.ebi.ac.uk/interpro/entry/IPR003583 InterPro IPR004509 http://www.ebi.ac.uk/interpro/entry/IPR004509 InterPro IPR010994 http://www.ebi.ac.uk/interpro/entry/IPR010994 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW0432 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0432 KEGG_Gene eco:b0442 http://www.genome.jp/dbget-bin/www_bget?eco:b0442 KEGG_Orthology KO:K02237 http://www.genome.jp/dbget-bin/www_bget?KO:K02237 OMA VERNMAV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VERNMAV PSORT swissprot:YBAV_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBAV_ECOLI PSORT-B swissprot:YBAV_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBAV_ECOLI PSORT2 swissprot:YBAV_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBAV_ECOLI Phobius swissprot:YBAV_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBAV_ECOLI PhylomeDB P0AAR8 http://phylomedb.org/?seqid=P0AAR8 ProteinModelPortal P0AAR8 http://www.proteinmodelportal.org/query/uniprot/P0AAR8 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414976 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414976 RefSeq WP_000680312 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000680312 SMART SM00278 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00278 SMR P0AAR8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAR8 STRING 511145.b0442 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0442&targetmode=cogs STRING COG1555 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1555&targetmode=cogs SUPFAM SSF47781 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47781 TIGRFAMs TIGR00426 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00426 UniProtKB YBAV_ECOLI http://www.uniprot.org/uniprot/YBAV_ECOLI UniProtKB-AC P0AAR8 http://www.uniprot.org/uniprot/P0AAR8 charge swissprot:YBAV_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBAV_ECOLI eggNOG COG1555 http://eggnogapi.embl.de/nog_data/html/tree/COG1555 eggNOG ENOG41083P1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41083P1 epestfind swissprot:YBAV_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBAV_ECOLI garnier swissprot:YBAV_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBAV_ECOLI helixturnhelix swissprot:YBAV_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBAV_ECOLI hmoment swissprot:YBAV_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBAV_ECOLI iep swissprot:YBAV_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBAV_ECOLI inforesidue swissprot:YBAV_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBAV_ECOLI octanol swissprot:YBAV_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBAV_ECOLI pepcoil swissprot:YBAV_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBAV_ECOLI pepdigest swissprot:YBAV_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBAV_ECOLI pepinfo swissprot:YBAV_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBAV_ECOLI pepnet swissprot:YBAV_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBAV_ECOLI pepstats swissprot:YBAV_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBAV_ECOLI pepwheel swissprot:YBAV_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBAV_ECOLI pepwindow swissprot:YBAV_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBAV_ECOLI sigcleave swissprot:YBAV_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBAV_ECOLI ## Database ID URL or Descriptions # AltName FABZ_ECOLI (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase # AltName FABZ_ECOLI 17 kDa actomyosin component # AltName FABZ_ECOLI Beta-hydroxyacyl-ACP dehydratase # BioGrid 4263243 422 # CATALYTIC ACTIVITY A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H(2)O. {ECO:0000269|PubMed 8910376}. # EcoGene EG11284 fabZ # FUNCTION FABZ_ECOLI Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. {ECO 0000269|PubMed 7806516, ECO 0000269|PubMed 8910376}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0008693 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0047451 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity; IDA:EcoCyc. # GO_process GO:0006633 fatty acid biosynthetic process; IDA:EcoCyc. # GO_process GO:0009245 lipid A biosynthetic process; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.10.129.10 -; 1. # HAMAP MF_00406 FabZ # IntAct P0A6Q6 33 # InterPro IPR010084 FabZ # InterPro IPR013114 FabA_FabZ # InterPro IPR029069 HotDog_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01004 Lipid biosynthesis proteins # KEGG_Pathway ko00061 Fatty acid biosynthesis # KEGG_Pathway ko00780 Biotin metabolism # Organism FABZ_ECOLI Escherichia coli (strain K12) # PATRIC 32115471 VBIEscCol129921_0187 # PIR D64742 D64742 # PTM FABZ_ECOLI The N-terminus is blocked. # Pfam PF07977 FabA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FABZ_ECOLI 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ # RefSeq NP_414722 NC_000913.3 # RefSeq WP_000210739 NZ_LN832404.1 # SIMILARITY Belongs to the thioester dehydratase family. FabZ subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION FABZ_ECOLI Cytoplasm. # SUBUNIT FABZ_ECOLI Oligomer. # SUPFAM SSF54637 SSF54637 # TIGRFAMs TIGR01750 fabZ # eggNOG COG0764 LUCA # eggNOG ENOG4108YXN Bacteria BLAST swissprot:FABZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FABZ_ECOLI BioCyc ECOL316407:JW0175-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0175-MONOMER BioCyc EcoCyc:FABZ-MONOMER http://biocyc.org/getid?id=EcoCyc:FABZ-MONOMER BioCyc MetaCyc:FABZ-MONOMER http://biocyc.org/getid?id=MetaCyc:FABZ-MONOMER COG COG0764 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0764 DIP DIP-31868N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31868N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1999.01221.x http://dx.doi.org/10.1046/j.1365-2958.1999.01221.x DOI 10.1074/jbc.271.44.27795 http://dx.doi.org/10.1074/jbc.271.44.27795 DOI 10.1111/j.1574-6968.1993.tb06338.x http://dx.doi.org/10.1111/j.1574-6968.1993.tb06338.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.1.59 http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.59 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M19334 http://www.ebi.ac.uk/ena/data/view/M19334 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 ENZYME 4.2.1.59 http://enzyme.expasy.org/EC/4.2.1.59 EchoBASE EB1261 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1261 EcoGene EG11284 http://www.ecogene.org/geneInfo.php?eg_id=EG11284 EnsemblBacteria AAC73291 http://www.ensemblgenomes.org/id/AAC73291 EnsemblBacteria AAC73291 http://www.ensemblgenomes.org/id/AAC73291 EnsemblBacteria BAA77855 http://www.ensemblgenomes.org/id/BAA77855 EnsemblBacteria BAA77855 http://www.ensemblgenomes.org/id/BAA77855 EnsemblBacteria BAA77855 http://www.ensemblgenomes.org/id/BAA77855 EnsemblBacteria b0180 http://www.ensemblgenomes.org/id/b0180 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0008693 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008693 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0047451 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047451 GO_process GO:0006633 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006633 GO_process GO:0009245 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009245 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.10.129.10 http://www.cathdb.info/version/latest/superfamily/3.10.129.10 GeneID 944888 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944888 HAMAP MF_00406 http://hamap.expasy.org/unirule/MF_00406 HOGENOM HOG000277829 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000277829&db=HOGENOM6 InParanoid P0A6Q6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6Q6 IntAct P0A6Q6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6Q6* IntEnz 4.2.1.59 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.59 InterPro IPR010084 http://www.ebi.ac.uk/interpro/entry/IPR010084 InterPro IPR013114 http://www.ebi.ac.uk/interpro/entry/IPR013114 InterPro IPR029069 http://www.ebi.ac.uk/interpro/entry/IPR029069 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01004 http://www.genome.jp/dbget-bin/www_bget?ko01004 KEGG_Gene ecj:JW0175 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0175 KEGG_Gene eco:b0180 http://www.genome.jp/dbget-bin/www_bget?eco:b0180 KEGG_Orthology KO:K02372 http://www.genome.jp/dbget-bin/www_bget?KO:K02372 KEGG_Pathway ko00061 http://www.genome.jp/kegg-bin/show_pathway?ko00061 KEGG_Pathway ko00780 http://www.genome.jp/kegg-bin/show_pathway?ko00780 KEGG_Reaction rn:R04428 http://www.genome.jp/dbget-bin/www_bget?rn:R04428 KEGG_Reaction rn:R04535 http://www.genome.jp/dbget-bin/www_bget?rn:R04535 KEGG_Reaction rn:R04537 http://www.genome.jp/dbget-bin/www_bget?rn:R04537 KEGG_Reaction rn:R04544 http://www.genome.jp/dbget-bin/www_bget?rn:R04544 KEGG_Reaction rn:R04568 http://www.genome.jp/dbget-bin/www_bget?rn:R04568 KEGG_Reaction rn:R04954 http://www.genome.jp/dbget-bin/www_bget?rn:R04954 KEGG_Reaction rn:R04965 http://www.genome.jp/dbget-bin/www_bget?rn:R04965 KEGG_Reaction rn:R07764 http://www.genome.jp/dbget-bin/www_bget?rn:R07764 KEGG_Reaction rn:R10117 http://www.genome.jp/dbget-bin/www_bget?rn:R10117 KEGG_Reaction rn:R10121 http://www.genome.jp/dbget-bin/www_bget?rn:R10121 MINT MINT-1218564 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1218564 OMA EMMCARR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EMMCARR PSORT swissprot:FABZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FABZ_ECOLI PSORT-B swissprot:FABZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FABZ_ECOLI PSORT2 swissprot:FABZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FABZ_ECOLI Pfam PF07977 http://pfam.xfam.org/family/PF07977 Phobius swissprot:FABZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FABZ_ECOLI PhylomeDB P0A6Q6 http://phylomedb.org/?seqid=P0A6Q6 ProteinModelPortal P0A6Q6 http://www.proteinmodelportal.org/query/uniprot/P0A6Q6 PubMed 10048027 http://www.ncbi.nlm.nih.gov/pubmed/10048027 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3277952 http://www.ncbi.nlm.nih.gov/pubmed/3277952 PubMed 7806516 http://www.ncbi.nlm.nih.gov/pubmed/7806516 PubMed 8354462 http://www.ncbi.nlm.nih.gov/pubmed/8354462 PubMed 8910376 http://www.ncbi.nlm.nih.gov/pubmed/8910376 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414722 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414722 RefSeq WP_000210739 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000210739 SMR P0A6Q6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6Q6 STRING 511145.b0180 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0180&targetmode=cogs STRING COG0764 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0764&targetmode=cogs SUPFAM SSF54637 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54637 TIGRFAMs TIGR01750 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01750 UniProtKB FABZ_ECOLI http://www.uniprot.org/uniprot/FABZ_ECOLI UniProtKB-AC P0A6Q6 http://www.uniprot.org/uniprot/P0A6Q6 charge swissprot:FABZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FABZ_ECOLI eggNOG COG0764 http://eggnogapi.embl.de/nog_data/html/tree/COG0764 eggNOG ENOG4108YXN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108YXN epestfind swissprot:FABZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FABZ_ECOLI garnier swissprot:FABZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FABZ_ECOLI helixturnhelix swissprot:FABZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FABZ_ECOLI hmoment swissprot:FABZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FABZ_ECOLI iep swissprot:FABZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FABZ_ECOLI inforesidue swissprot:FABZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FABZ_ECOLI octanol swissprot:FABZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FABZ_ECOLI pepcoil swissprot:FABZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FABZ_ECOLI pepdigest swissprot:FABZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FABZ_ECOLI pepinfo swissprot:FABZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FABZ_ECOLI pepnet swissprot:FABZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FABZ_ECOLI pepstats swissprot:FABZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FABZ_ECOLI pepwheel swissprot:FABZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FABZ_ECOLI pepwindow swissprot:FABZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FABZ_ECOLI sigcleave swissprot:FABZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FABZ_ECOLI ## Database ID URL or Descriptions # BioGrid 4260073 122 # CATALYTIC ACTIVITY THIK_ECOLI ATP + thiamine = ADP + thiamine phosphate. # EcoGene EG13432 thiK # FUNCTION THIK_ECOLI Catalyzes the phosphorylation of thiamine to thiamine phosphate. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0019165 thiamine kinase activity; IMP:EcoCyc. # GO_process GO:0006772 thiamine metabolic process; IEA:InterPro. # GO_process GO:0009229 thiamine diphosphate biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # HAMAP MF_01604 Thiamine_kinase # IntAct P75948 5 # InterPro IPR002575 Aminoglycoside_PTrfase # InterPro IPR011009 Kinase-like_dom # InterPro IPR014093 Thiamine_kinase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00730 Thiamine metabolism # Organism THIK_ECOLI Escherichia coli (strain K12) # PATHWAY Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from thiamine step 1/1. # PATRIC 32117455 VBIEscCol129921_1150 # PIR G64854 G64854 # Pfam PF01636 APH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName THIK_ECOLI Thiamine kinase # RefSeq NP_415624 NC_000913.3 # RefSeq WP_001116592 NZ_LN832404.1 # SIMILARITY Belongs to the thiamine kinase family. {ECO 0000305}. # SUPFAM SSF56112 SSF56112 # TIGRFAMs TIGR02721 ycfN_thiK # UniPathway UPA00060 UER00596 # eggNOG COG0510 LUCA # eggNOG ENOG4108RUM Bacteria BLAST swissprot:THIK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:THIK_ECOLI BioCyc ECOL316407:JW1092-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1092-MONOMER BioCyc EcoCyc:THIKIN-MONOMER http://biocyc.org/getid?id=EcoCyc:THIKIN-MONOMER BioCyc MetaCyc:THIKIN-MONOMER http://biocyc.org/getid?id=MetaCyc:THIKIN-MONOMER COG COG0510 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0510 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.186.11.3660-3662.2004 http://dx.doi.org/10.1128/JB.186.11.3660-3662.2004 EC_number EC:2.7.1.89 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.89 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.89 http://enzyme.expasy.org/EC/2.7.1.89 EchoBASE EB3206 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3206 EcoGene EG13432 http://www.ecogene.org/geneInfo.php?eg_id=EG13432 EnsemblBacteria AAC74190 http://www.ensemblgenomes.org/id/AAC74190 EnsemblBacteria AAC74190 http://www.ensemblgenomes.org/id/AAC74190 EnsemblBacteria BAA35913 http://www.ensemblgenomes.org/id/BAA35913 EnsemblBacteria BAA35913 http://www.ensemblgenomes.org/id/BAA35913 EnsemblBacteria BAA35913 http://www.ensemblgenomes.org/id/BAA35913 EnsemblBacteria b1106 http://www.ensemblgenomes.org/id/b1106 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0019165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019165 GO_process GO:0006772 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006772 GO_process GO:0009229 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009229 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GeneID 948525 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948525 HAMAP MF_01604 http://hamap.expasy.org/unirule/MF_01604 HOGENOM HOG000219316 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219316&db=HOGENOM6 IntAct P75948 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75948* IntEnz 2.7.1.89 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.89 InterPro IPR002575 http://www.ebi.ac.uk/interpro/entry/IPR002575 InterPro IPR011009 http://www.ebi.ac.uk/interpro/entry/IPR011009 InterPro IPR014093 http://www.ebi.ac.uk/interpro/entry/IPR014093 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1092 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1092 KEGG_Gene eco:b1106 http://www.genome.jp/dbget-bin/www_bget?eco:b1106 KEGG_Orthology KO:K07251 http://www.genome.jp/dbget-bin/www_bget?KO:K07251 KEGG_Pathway ko00730 http://www.genome.jp/kegg-bin/show_pathway?ko00730 KEGG_Reaction rn:R02134 http://www.genome.jp/dbget-bin/www_bget?rn:R02134 OMA DYLVLMW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DYLVLMW PSORT swissprot:THIK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:THIK_ECOLI PSORT-B swissprot:THIK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:THIK_ECOLI PSORT2 swissprot:THIK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:THIK_ECOLI Pfam PF01636 http://pfam.xfam.org/family/PF01636 Phobius swissprot:THIK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:THIK_ECOLI ProteinModelPortal P75948 http://www.proteinmodelportal.org/query/uniprot/P75948 PubMed 15150256 http://www.ncbi.nlm.nih.gov/pubmed/15150256 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415624 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415624 RefSeq WP_001116592 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001116592 SMR P75948 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75948 STRING 511145.b1106 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1106&targetmode=cogs STRING COG0510 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0510&targetmode=cogs SUPFAM SSF56112 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56112 TIGRFAMs TIGR02721 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02721 UniProtKB THIK_ECOLI http://www.uniprot.org/uniprot/THIK_ECOLI UniProtKB-AC P75948 http://www.uniprot.org/uniprot/P75948 charge swissprot:THIK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:THIK_ECOLI eggNOG COG0510 http://eggnogapi.embl.de/nog_data/html/tree/COG0510 eggNOG ENOG4108RUM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108RUM epestfind swissprot:THIK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:THIK_ECOLI garnier swissprot:THIK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:THIK_ECOLI helixturnhelix swissprot:THIK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:THIK_ECOLI hmoment swissprot:THIK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:THIK_ECOLI iep swissprot:THIK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:THIK_ECOLI inforesidue swissprot:THIK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:THIK_ECOLI octanol swissprot:THIK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:THIK_ECOLI pepcoil swissprot:THIK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:THIK_ECOLI pepdigest swissprot:THIK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:THIK_ECOLI pepinfo swissprot:THIK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:THIK_ECOLI pepnet swissprot:THIK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:THIK_ECOLI pepstats swissprot:THIK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:THIK_ECOLI pepwheel swissprot:THIK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:THIK_ECOLI pepwindow swissprot:THIK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:THIK_ECOLI sigcleave swissprot:THIK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:THIK_ECOLI ## Database ID URL or Descriptions # AltName Deoxycytidine triphosphate deaminase {ECO:0000255|HAMAP-Rule MF_00146} # BRENDA 3.5.4.13 2026 # BioGrid 4259684 4 # CATALYTIC ACTIVITY DCD_ECOLI dCTP + H(2)O = dUTP + NH(3). {ECO 0000255|HAMAP-Rule MF_00146, ECO 0000269|PubMed 1324907}. # CDD cd07557 trimeric_dUTPase # DISRUPTION PHENOTYPE Mutant accumulates dCTP. {ECO:0000269|PubMed 1324907}. # EcoGene EG11418 dcd # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008829 dCTP deaminase activity; IDA:EcoCyc. # GO_process GO:0006226 dUMP biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0006229 dUTP biosynthetic process; IEA:InterPro. # GO_process GO:0009220 pyrimidine ribonucleotide biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0015949 nucleobase-containing small molecule interconversion; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 2.70.40.10 -; 1. # HAMAP MF_00146 dCTP_deaminase # IntAct P28248 2 # InterPro IPR008180 dUTPase/dCTP_deaminase # InterPro IPR011962 dCTP_deam # InterPro IPR029054 dUTPase-like # InterPro IPR033704 dUTPase_trimeric # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00240 Pyrimidine metabolism # Organism DCD_ECOLI Escherichia coli (strain K12) # PATHWAY DCD_ECOLI Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route) step 1/2. {ECO 0000255|HAMAP-Rule MF_00146, ECO 0000269|PubMed 1324907}. # PATRIC 32119463 VBIEscCol129921_2142 # PDB 1XS1 X-ray; 1.80 A; A/B/C/D/E/F=1-193 # PDB 1XS4 X-ray; 2.53 A; A/B/C/D/E/F=1-193 # PDB 1XS6 X-ray; 2.00 A; A/B/C/D/E/F=1-193 # PDB 2J4H X-ray; 2.70 A; A/B=1-193 # PDB 2J4Q X-ray; 2.60 A; A/B=1-193 # PDB 2V9X X-ray; 2.20 A; A/B/C/D/E/F/G/H/I/J/K/L=1-193 # PIR A42940 A42940 # Pfam PF00692 dUTPase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DCD_ECOLI dCTP deaminase {ECO 0000255|HAMAP-Rule MF_00146, ECO 0000303|PubMed 1324907} # RefSeq NP_416569 NC_000913.3 # RefSeq WP_001234768 NZ_LN832404.1 # SIMILARITY Belongs to the dCTP deaminase family. {ECO:0000255|HAMAP-Rule MF_00146, ECO:0000305}. # SUBUNIT Homotetramer. {ECO 0000305}. # SUPFAM SSF51283 SSF51283 # TIGRFAMs TIGR02274 dCTP_deam # UniPathway UPA00610 UER00665 # eggNOG COG0717 LUCA # eggNOG ENOG4105DHP Bacteria BLAST swissprot:DCD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DCD_ECOLI BioCyc ECOL316407:JW2050-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2050-MONOMER BioCyc EcoCyc:DCTP-DEAM-MONOMER http://biocyc.org/getid?id=EcoCyc:DCTP-DEAM-MONOMER BioCyc MetaCyc:DCTP-DEAM-MONOMER http://biocyc.org/getid?id=MetaCyc:DCTP-DEAM-MONOMER COG COG0717 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0717 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.5.4.13 {ECO:0000255|HAMAP-Rule:MF_00146, ECO:0000269|PubMed:1324907} http://www.genome.jp/dbget-bin/www_bget?EC:3.5.4.13 {ECO:0000255|HAMAP-Rule:MF_00146, ECO:0000269|PubMed:1324907} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M90069 http://www.ebi.ac.uk/ena/data/view/M90069 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.5.4.13 {ECO:0000255|HAMAP-Rule:MF_00146, ECO:0000269|PubMed:1324907} http://enzyme.expasy.org/EC/3.5.4.13 {ECO:0000255|HAMAP-Rule:MF_00146, ECO:0000269|PubMed:1324907} EchoBASE EB1389 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1389 EcoGene EG11418 http://www.ecogene.org/geneInfo.php?eg_id=EG11418 EnsemblBacteria AAC75126 http://www.ensemblgenomes.org/id/AAC75126 EnsemblBacteria AAC75126 http://www.ensemblgenomes.org/id/AAC75126 EnsemblBacteria BAA15918 http://www.ensemblgenomes.org/id/BAA15918 EnsemblBacteria BAA15918 http://www.ensemblgenomes.org/id/BAA15918 EnsemblBacteria BAA15918 http://www.ensemblgenomes.org/id/BAA15918 EnsemblBacteria b2065 http://www.ensemblgenomes.org/id/b2065 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008829 GO_process GO:0006226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006226 GO_process GO:0006229 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006229 GO_process GO:0009220 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009220 GO_process GO:0015949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015949 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 2.70.40.10 http://www.cathdb.info/version/latest/superfamily/2.70.40.10 GeneID 946593 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946593 HAMAP MF_00146 http://hamap.expasy.org/unirule/MF_00146 HOGENOM HOG000228601 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000228601&db=HOGENOM6 InParanoid P28248 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P28248 IntAct P28248 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P28248* IntEnz 3.5.4.13 {ECO:0000255|HAMAP-Rule:MF_00146, ECO:0000269|PubMed:1324907} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.4.13 {ECO:0000255|HAMAP-Rule:MF_00146, ECO:0000269|PubMed:1324907} InterPro IPR008180 http://www.ebi.ac.uk/interpro/entry/IPR008180 InterPro IPR011962 http://www.ebi.ac.uk/interpro/entry/IPR011962 InterPro IPR029054 http://www.ebi.ac.uk/interpro/entry/IPR029054 InterPro IPR033704 http://www.ebi.ac.uk/interpro/entry/IPR033704 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2050 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2050 KEGG_Gene eco:b2065 http://www.genome.jp/dbget-bin/www_bget?eco:b2065 KEGG_Orthology KO:K01494 http://www.genome.jp/dbget-bin/www_bget?KO:K01494 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Reaction rn:R00568 http://www.genome.jp/dbget-bin/www_bget?rn:R00568 KEGG_Reaction rn:R02325 http://www.genome.jp/dbget-bin/www_bget?rn:R02325 OMA NIPCIHP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NIPCIHP PDB 1XS1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1XS1 PDB 1XS4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1XS4 PDB 1XS6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1XS6 PDB 2J4H http://www.ebi.ac.uk/pdbe-srv/view/entry/2J4H PDB 2J4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/2J4Q PDB 2V9X http://www.ebi.ac.uk/pdbe-srv/view/entry/2V9X PDBsum 1XS1 http://www.ebi.ac.uk/pdbsum/1XS1 PDBsum 1XS4 http://www.ebi.ac.uk/pdbsum/1XS4 PDBsum 1XS6 http://www.ebi.ac.uk/pdbsum/1XS6 PDBsum 2J4H http://www.ebi.ac.uk/pdbsum/2J4H PDBsum 2J4Q http://www.ebi.ac.uk/pdbsum/2J4Q PDBsum 2V9X http://www.ebi.ac.uk/pdbsum/2V9X PSORT swissprot:DCD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DCD_ECOLI PSORT-B swissprot:DCD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DCD_ECOLI PSORT2 swissprot:DCD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DCD_ECOLI Pfam PF00692 http://pfam.xfam.org/family/PF00692 Phobius swissprot:DCD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DCD_ECOLI PhylomeDB P28248 http://phylomedb.org/?seqid=P28248 ProteinModelPortal P28248 http://www.proteinmodelportal.org/query/uniprot/P28248 PubMed 1324907 http://www.ncbi.nlm.nih.gov/pubmed/1324907 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416569 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416569 RefSeq WP_001234768 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001234768 SMR P28248 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P28248 STRING 511145.b2065 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2065&targetmode=cogs STRING COG0717 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0717&targetmode=cogs SUPFAM SSF51283 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51283 TIGRFAMs TIGR02274 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02274 UniProtKB DCD_ECOLI http://www.uniprot.org/uniprot/DCD_ECOLI UniProtKB-AC P28248 http://www.uniprot.org/uniprot/P28248 charge swissprot:DCD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DCD_ECOLI eggNOG COG0717 http://eggnogapi.embl.de/nog_data/html/tree/COG0717 eggNOG ENOG4105DHP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DHP epestfind swissprot:DCD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DCD_ECOLI garnier swissprot:DCD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DCD_ECOLI helixturnhelix swissprot:DCD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DCD_ECOLI hmoment swissprot:DCD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DCD_ECOLI iep swissprot:DCD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DCD_ECOLI inforesidue swissprot:DCD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DCD_ECOLI octanol swissprot:DCD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DCD_ECOLI pepcoil swissprot:DCD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DCD_ECOLI pepdigest swissprot:DCD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DCD_ECOLI pepinfo swissprot:DCD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DCD_ECOLI pepnet swissprot:DCD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DCD_ECOLI pepstats swissprot:DCD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DCD_ECOLI pepwheel swissprot:DCD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DCD_ECOLI pepwindow swissprot:DCD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DCD_ECOLI sigcleave swissprot:DCD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DCD_ECOLI ## Database ID URL or Descriptions # AltName YOEB_ECOLI Putative endoribonuclease YoeB # AltName YOEB_ECOLI Putative mRNA interferase Yoeb # BioGrid 4260402 128 # DISRUPTION PHENOTYPE YOEB_ECOLI No visible phenotype under standard growth conditions. Delays Lon protease-dependent lethality upon overexpression of Lon, but does not fully suppress it. No loss of ability to form persister cells. {ECO 0000269|PubMed 15009896, ECO 0000269|PubMed 16768798}. # EcoGene EG14356 yoeB # FUNCTION YOEB_ECOLI Also shown in vitro to be a translation initiation blocker. Binds to the 70S ribosome and 50S ribosomal subunit; binding is inhibited by hygromycin A and tetracycline, both of which bind to the 30S subunit in the A site. Thus YoeB is located at the interface between 50S and 30S ribosomes and interacts with the A site where it cleaves mRNA, blocking translation initiation. # FUNCTION YOEB_ECOLI Shown in vitro to be an mRNA interferase that requires translation for substrate cleavage; if the mRNA is mutated so as to not be translatable it is no longer cleaved. Cleavage only occurs within translated regions. Has RNase activity and preferentially cleaves at the 3'-end of purine ribonucleotides. # FUNCTION YOEB_ECOLI Toxic component of a toxin-antitoxin (TA) module. Its mode of function is controversial; it has been proposed to be an mRNA interferase but also an inhibitor of translation initiation. When overproduced in wild-type cells, inhibits bacterial growth and translation by cleavage of mRNA molecules while it has a weak effect on colony forming ability. Overproduction of Lon protease specifically activates YoeB-dependent mRNA cleavage, leading to lethality. YefM binds to the promoter region of the yefM-yeoB operon to repress transcription, YeoB acts as a corepressor. # GO_function GO:0003714 transcription corepressor activity; IDA:UniProtKB. # GO_function GO:0003723 RNA binding; IEA:UniProtKB-KW. # GO_function GO:0004521 endoribonuclease activity; IDA:EcoCyc. # GO_function GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters; IDA:EcoCyc. # GO_function GO:0043024 ribosomal small subunit binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006402 mRNA catabolic process; IDA:EcoCyc. # GO_process GO:0044010 single-species biofilm formation; IMP:EcoCyc. # GO_process GO:0045947 negative regulation of translational initiation; IDA:EcoCyc. # GO_process GO:0098795 mRNA cleavage involved in gene silencing; IDA:UniProtKB. # GOslim_function GO:0000988 transcription factor activity, protein binding # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0004518 nuclease activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # INDUCTION YOEB_ECOLI Repressed by YefM, more strongly repressed by the YefM(2)YoeB heterotrimer. Induced in persister cells. Ectopic expression of Salmonella or Shigella toxin VapC induces the yefM- yoeB operon and also induces Yoeb toxin activity in a Lon protease-dependent manner. {ECO 0000269|PubMed 16768798, ECO 0000269|PubMed 17170003, ECO 0000269|PubMed 19400780}. # InterPro IPR009614 YoeB_toxin # KEGG_Brite ko01000 Enzymes # Organism YOEB_ECOLI Escherichia coli (strain K12) # PATRIC 32119369 VBIEscCol129921_2094 # PDB 2A6Q X-ray; 2.05 A; E/F=1-84 # PDB 2A6R X-ray; 2.05 A; A/B/C/D/E/F=1-84 # PDB 2A6S X-ray; 1.77 A; A/B/C/D=1-84 # PDB 4V8X X-ray; 3.35 A; AY/AZ/CY/CZ=1-84 # Pfam PF06769 YoeB_toxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YOEB_ECOLI Toxin YoeB # RefSeq WP_000767829 NZ_LN832404.1 # RefSeq YP_588458 NC_000913.3 # SIMILARITY Belongs to the YoeB family. {ECO 0000305}. # SUBUNIT YOEB_ECOLI Forms a complex with antitoxin YefM, in which the toxin is inactive. It has been described as being a YefM-YeoB(2) heterotrimer (PubMed 15980067). Also described as a YefM(2)-YoeB heterotrimer (PubMed 16109374 and PubMed 17170003). Binds the 50S ribosomal subunit. {ECO 0000269|PubMed 15980067, ECO 0000269|PubMed 16109374, ECO 0000269|PubMed 17170003}. # TIGRFAMs TIGR02116 toxin_Txe_YoeB # eggNOG COG4115 LUCA # eggNOG ENOG4105KRQ Bacteria BLAST swissprot:YOEB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YOEB_ECOLI BioCyc ECOL316407:JW5331-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5331-MONOMER BioCyc EcoCyc:MONOMER0-1041 http://biocyc.org/getid?id=EcoCyc:MONOMER0-1041 BioCyc MetaCyc:MONOMER0-1041 http://biocyc.org/getid?id=MetaCyc:MONOMER0-1041 DOI 10.1016/j.molcel.2005.07.004 http://dx.doi.org/10.1016/j.molcel.2005.07.004 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2003.03941.x http://dx.doi.org/10.1046/j.1365-2958.2003.03941.x DOI 10.1074/jbc.M308263200 http://dx.doi.org/10.1074/jbc.M308263200 DOI 10.1074/jbc.M506220200 http://dx.doi.org/10.1074/jbc.M506220200 DOI 10.1074/jbc.M808779200 http://dx.doi.org/10.1074/jbc.M808779200 DOI 10.1093/nar/gkl1028 http://dx.doi.org/10.1093/nar/gkl1028 DOI 10.1093/nar/gkn667 http://dx.doi.org/10.1093/nar/gkn667 DOI 10.1111/j.1365-2958.2009.06694.x http://dx.doi.org/10.1111/j.1365-2958.2009.06694.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01331-08 http://dx.doi.org/10.1128/JB.01331-08 DOI 10.1186/1471-2180-6-53 http://dx.doi.org/10.1186/1471-2180-6-53 EC_number EC:3.1.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.-.- http://enzyme.expasy.org/EC/3.1.-.- EchoBASE EB4102 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4102 EcoGene EG14356 http://www.ecogene.org/geneInfo.php?eg_id=EG14356 EnsemblBacteria ABD18681 http://www.ensemblgenomes.org/id/ABD18681 EnsemblBacteria ABD18681 http://www.ensemblgenomes.org/id/ABD18681 EnsemblBacteria BAE76569 http://www.ensemblgenomes.org/id/BAE76569 EnsemblBacteria BAE76569 http://www.ensemblgenomes.org/id/BAE76569 EnsemblBacteria BAE76569 http://www.ensemblgenomes.org/id/BAE76569 EnsemblBacteria b4539 http://www.ensemblgenomes.org/id/b4539 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003714 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003714 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0004521 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004521 GO_function GO:0016892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016892 GO_function GO:0043024 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043024 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0006402 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006402 GO_process GO:0044010 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044010 GO_process GO:0045947 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045947 GO_process GO:0098795 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098795 GOslim_function GO:0000988 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000988 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 GeneID 1450274 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1450274 HOGENOM HOG000216470 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000216470&db=HOGENOM6 InParanoid P69348 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P69348 IntAct P69348 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69348* IntEnz 3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1 InterPro IPR009614 http://www.ebi.ac.uk/interpro/entry/IPR009614 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5331 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5331 KEGG_Gene eco:b4539 http://www.genome.jp/dbget-bin/www_bget?eco:b4539 KEGG_Orthology KO:K01175 http://www.genome.jp/dbget-bin/www_bget?KO:K01175 OMA KCRFHYD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KCRFHYD PDB 2A6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/2A6Q PDB 2A6R http://www.ebi.ac.uk/pdbe-srv/view/entry/2A6R PDB 2A6S http://www.ebi.ac.uk/pdbe-srv/view/entry/2A6S PDB 4V8X http://www.ebi.ac.uk/pdbe-srv/view/entry/4V8X PDBsum 2A6Q http://www.ebi.ac.uk/pdbsum/2A6Q PDBsum 2A6R http://www.ebi.ac.uk/pdbsum/2A6R PDBsum 2A6S http://www.ebi.ac.uk/pdbsum/2A6S PDBsum 4V8X http://www.ebi.ac.uk/pdbsum/4V8X PSORT swissprot:YOEB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YOEB_ECOLI PSORT-B swissprot:YOEB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YOEB_ECOLI PSORT2 swissprot:YOEB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YOEB_ECOLI Pfam PF06769 http://pfam.xfam.org/family/PF06769 Phobius swissprot:YOEB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YOEB_ECOLI PhylomeDB P69348 http://phylomedb.org/?seqid=P69348 ProteinModelPortal P69348 http://www.proteinmodelportal.org/query/uniprot/P69348 PubMed 14672926 http://www.ncbi.nlm.nih.gov/pubmed/14672926 PubMed 15009896 http://www.ncbi.nlm.nih.gov/pubmed/15009896 PubMed 15980067 http://www.ncbi.nlm.nih.gov/pubmed/15980067 PubMed 16109374 http://www.ncbi.nlm.nih.gov/pubmed/16109374 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16768798 http://www.ncbi.nlm.nih.gov/pubmed/16768798 PubMed 17170003 http://www.ncbi.nlm.nih.gov/pubmed/17170003 PubMed 18854355 http://www.ncbi.nlm.nih.gov/pubmed/18854355 PubMed 19028895 http://www.ncbi.nlm.nih.gov/pubmed/19028895 PubMed 19124462 http://www.ncbi.nlm.nih.gov/pubmed/19124462 PubMed 19400780 http://www.ncbi.nlm.nih.gov/pubmed/19400780 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000767829 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000767829 RefSeq YP_588458 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_588458 SMR P69348 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69348 STRING 511145.b4539 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4539&targetmode=cogs TIGRFAMs TIGR02116 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02116 UniProtKB YOEB_ECOLI http://www.uniprot.org/uniprot/YOEB_ECOLI UniProtKB-AC P69348 http://www.uniprot.org/uniprot/P69348 charge swissprot:YOEB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YOEB_ECOLI eggNOG COG4115 http://eggnogapi.embl.de/nog_data/html/tree/COG4115 eggNOG ENOG4105KRQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KRQ epestfind swissprot:YOEB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YOEB_ECOLI garnier swissprot:YOEB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YOEB_ECOLI helixturnhelix swissprot:YOEB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YOEB_ECOLI hmoment swissprot:YOEB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YOEB_ECOLI iep swissprot:YOEB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YOEB_ECOLI inforesidue swissprot:YOEB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YOEB_ECOLI octanol swissprot:YOEB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YOEB_ECOLI pepcoil swissprot:YOEB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YOEB_ECOLI pepdigest swissprot:YOEB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YOEB_ECOLI pepinfo swissprot:YOEB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YOEB_ECOLI pepnet swissprot:YOEB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YOEB_ECOLI pepstats swissprot:YOEB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YOEB_ECOLI pepwheel swissprot:YOEB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YOEB_ECOLI pepwindow swissprot:YOEB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YOEB_ECOLI sigcleave swissprot:YOEB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YOEB_ECOLI ## Database ID URL or Descriptions # EcoGene EG14493 rzoQ # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GOslim_component GO:0005886 plasma membrane # MISCELLANEOUS RZOQ_ECOLI Entirely encoded within the coding gene for rzpQ (AC P76158), on the same strand within another reading frame. # Organism RZOQ_ECOLI Escherichia coli (strain K12) # PROSITE PS51257 PROKAR_LIPOPROTEIN # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RZOQ_ECOLI Putative lipoprotein RzoQ # RefSeq YP_002791241 NC_000913.3 # SUBCELLULAR LOCATION RZOQ_ECOLI Cell membrane {ECO 0000255|PROSITE- ProRule PRU00303}; Lipid-anchor {ECO 0000255|PROSITE- ProRule PRU00303}. # eggNOG ENOG410762J Bacteria # eggNOG ENOG410Z3CV LUCA BLAST swissprot:RZOQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RZOQ_ECOLI DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14493 http://www.ecogene.org/geneInfo.php?eg_id=EG14493 EnsemblBacteria ACO59993 http://www.ensemblgenomes.org/id/ACO59993 EnsemblBacteria ACO59993 http://www.ensemblgenomes.org/id/ACO59993 EnsemblBacteria b4689 http://www.ensemblgenomes.org/id/b4689 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 7751615 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7751615 KEGG_Gene eco:b4689 http://www.genome.jp/dbget-bin/www_bget?eco:b4689 PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:RZOQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RZOQ_ECOLI PSORT-B swissprot:RZOQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RZOQ_ECOLI PSORT2 swissprot:RZOQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RZOQ_ECOLI Phobius swissprot:RZOQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RZOQ_ECOLI PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq YP_002791241 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_002791241 STRING 511145.b4689 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4689&targetmode=cogs UniProtKB RZOQ_ECOLI http://www.uniprot.org/uniprot/RZOQ_ECOLI UniProtKB-AC C1P601 http://www.uniprot.org/uniprot/C1P601 charge swissprot:RZOQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RZOQ_ECOLI eggNOG ENOG410762J http://eggnogapi.embl.de/nog_data/html/tree/ENOG410762J eggNOG ENOG410Z3CV http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Z3CV epestfind swissprot:RZOQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RZOQ_ECOLI garnier swissprot:RZOQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RZOQ_ECOLI helixturnhelix swissprot:RZOQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RZOQ_ECOLI hmoment swissprot:RZOQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RZOQ_ECOLI iep swissprot:RZOQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RZOQ_ECOLI inforesidue swissprot:RZOQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RZOQ_ECOLI octanol swissprot:RZOQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RZOQ_ECOLI pepcoil swissprot:RZOQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RZOQ_ECOLI pepdigest swissprot:RZOQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RZOQ_ECOLI pepinfo swissprot:RZOQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RZOQ_ECOLI pepnet swissprot:RZOQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RZOQ_ECOLI pepstats swissprot:RZOQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RZOQ_ECOLI pepwheel swissprot:RZOQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RZOQ_ECOLI pepwindow swissprot:RZOQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RZOQ_ECOLI sigcleave swissprot:RZOQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RZOQ_ECOLI ## Database ID URL or Descriptions # AltName RFAF_ECOLI ADP-heptose--LPS heptosyltransferase II # BRENDA 2.4.99.B7 2026 # BioGrid 4263306 335 # CAZy GT9 Glycosyltransferase Family 9 # EcoGene EG12210 rfaF # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008713 ADP-heptose-lipopolysaccharide heptosyltransferase activity; IDA:CACAO. # GO_function GO:0016757 transferase activity, transferring glycosyl groups; IDA:EcoCyc. # GO_process GO:0009244 lipopolysaccharide core region biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # IntAct P37692 11 # InterPro IPR002201 Glyco_trans_9 # InterPro IPR011910 LipoPS_heptosylTferase-II # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01003 Glycosyltransferases # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # KEGG_Pathway ko00540 Lipopolysaccharide biosynthesis # Organism RFAF_ECOLI Escherichia coli (strain K12) # PATHWAY RFAF_ECOLI Bacterial outer membrane biogenesis; LPS core biosynthesis. # PATRIC 32122727 VBIEscCol129921_3740 # PDB 1PSW X-ray; 2.00 A; A=1-348 # PIR S47841 S47841 # Pfam PF01075 Glyco_transf_9 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RFAF_ECOLI ADP-heptose--LPS heptosyltransferase 2 # RefSeq NP_418077 NC_000913.3 # RefSeq WP_000699219 NZ_LN832404.1 # SIMILARITY Belongs to the glycosyltransferase 9 family. {ECO 0000305}. # TIGRFAMs TIGR02195 heptsyl_trn_II # eggNOG COG0859 LUCA # eggNOG ENOG4105XA0 Bacteria BLAST swissprot:RFAF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RFAF_ECOLI BioCyc ECOL316407:JW3595-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3595-MONOMER BioCyc EcoCyc:EG12210-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12210-MONOMER BioCyc MetaCyc:EG12210-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12210-MONOMER COG COG0859 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0859 DIP DIP-10667N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10667N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:2.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M33577 http://www.ebi.ac.uk/ena/data/view/M33577 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X62530 http://www.ebi.ac.uk/ena/data/view/X62530 ENZYME 2.-.-.- http://enzyme.expasy.org/EC/2.-.-.- EchoBASE EB2124 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2124 EcoGene EG12210 http://www.ecogene.org/geneInfo.php?eg_id=EG12210 EnsemblBacteria AAC76644 http://www.ensemblgenomes.org/id/AAC76644 EnsemblBacteria AAC76644 http://www.ensemblgenomes.org/id/AAC76644 EnsemblBacteria BAE77672 http://www.ensemblgenomes.org/id/BAE77672 EnsemblBacteria BAE77672 http://www.ensemblgenomes.org/id/BAE77672 EnsemblBacteria BAE77672 http://www.ensemblgenomes.org/id/BAE77672 EnsemblBacteria b3620 http://www.ensemblgenomes.org/id/b3620 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008713 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008713 GO_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GO_process GO:0009244 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009244 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 948135 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948135 HOGENOM HOG000237541 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000237541&db=HOGENOM6 InParanoid P37692 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37692 IntAct P37692 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37692* IntEnz 2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2 InterPro IPR002201 http://www.ebi.ac.uk/interpro/entry/IPR002201 InterPro IPR011910 http://www.ebi.ac.uk/interpro/entry/IPR011910 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01003 http://www.genome.jp/dbget-bin/www_bget?ko01003 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Gene ecj:JW3595 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3595 KEGG_Gene eco:b3620 http://www.genome.jp/dbget-bin/www_bget?eco:b3620 KEGG_Orthology KO:K02843 http://www.genome.jp/dbget-bin/www_bget?KO:K02843 KEGG_Pathway ko00540 http://www.genome.jp/kegg-bin/show_pathway?ko00540 OMA CLKQRHP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CLKQRHP PDB 1PSW http://www.ebi.ac.uk/pdbe-srv/view/entry/1PSW PDBsum 1PSW http://www.ebi.ac.uk/pdbsum/1PSW PSORT swissprot:RFAF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RFAF_ECOLI PSORT-B swissprot:RFAF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RFAF_ECOLI PSORT2 swissprot:RFAF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RFAF_ECOLI Pfam PF01075 http://pfam.xfam.org/family/PF01075 Phobius swissprot:RFAF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RFAF_ECOLI PhylomeDB P37692 http://phylomedb.org/?seqid=P37692 ProteinModelPortal P37692 http://www.proteinmodelportal.org/query/uniprot/P37692 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2198271 http://www.ncbi.nlm.nih.gov/pubmed/2198271 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 8478319 http://www.ncbi.nlm.nih.gov/pubmed/8478319 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418077 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418077 RefSeq WP_000699219 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000699219 SMR P37692 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37692 STRING 511145.b3620 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3620&targetmode=cogs STRING COG0859 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0859&targetmode=cogs TIGRFAMs TIGR02195 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02195 UniProtKB RFAF_ECOLI http://www.uniprot.org/uniprot/RFAF_ECOLI UniProtKB-AC P37692 http://www.uniprot.org/uniprot/P37692 charge swissprot:RFAF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RFAF_ECOLI eggNOG COG0859 http://eggnogapi.embl.de/nog_data/html/tree/COG0859 eggNOG ENOG4105XA0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105XA0 epestfind swissprot:RFAF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RFAF_ECOLI garnier swissprot:RFAF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RFAF_ECOLI helixturnhelix swissprot:RFAF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RFAF_ECOLI hmoment swissprot:RFAF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RFAF_ECOLI iep swissprot:RFAF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RFAF_ECOLI inforesidue swissprot:RFAF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RFAF_ECOLI octanol swissprot:RFAF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RFAF_ECOLI pepcoil swissprot:RFAF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RFAF_ECOLI pepdigest swissprot:RFAF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RFAF_ECOLI pepinfo swissprot:RFAF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RFAF_ECOLI pepnet swissprot:RFAF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RFAF_ECOLI pepstats swissprot:RFAF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RFAF_ECOLI pepwheel swissprot:RFAF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RFAF_ECOLI pepwindow swissprot:RFAF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RFAF_ECOLI sigcleave swissprot:RFAF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RFAF_ECOLI ## Database ID URL or Descriptions # BioGrid 4261038 235 # EcoGene EG10149 cheW # FUNCTION CHEW_ECOLI Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. It physically bridges CheA to the MCPs (methyl-accepting chemotaxis proteins) to allow regulated phosphotransfer to CheY and CheB. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004871 signal transducer activity; IEA:InterPro. # GO_process GO:0006935 chemotaxis; IMP:EcoCyc. # GO_process GO:0007165 signal transduction; IDA:EcoCyc. # GO_process GO:0051649 establishment of localization in cell; IMP:CACAO. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0004871 signal transducer activity # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0040011 locomotion # INTERACTION CHEW_ECOLI P07017 tar; NbExp=3; IntAct=EBI-1125947, EBI-1125130; # IntAct P0A964 31 # InterPro IPR002545 CheW # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Pathway ko02020 Two-component system # KEGG_Pathway ko02030 Bacterial chemotaxis # Organism CHEW_ECOLI Escherichia coli (strain K12) # PATRIC 32119101 VBIEscCol129921_1968 # PDB 2HO9 NMR; -; A=1-167 # PIR B25195 QRECCW # PROSITE PS50851 CHEW # Pfam PF01584 CheW # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CHEW_ECOLI Chemotaxis protein CheW # RefSeq NP_416401 NC_000913.3 # RefSeq WP_000147302 NZ_LN832404.1 # SIMILARITY Contains 1 cheW-like domain. {ECO:0000255|PROSITE- ProRule PRU00052}. # SMART SM00260 CheW # SUBCELLULAR LOCATION CHEW_ECOLI Cytoplasm. # SUBUNIT CHEW_ECOLI An in vitro complex of CheW/CheA(L)/CheA(S) in a 1 1 1 ratio increases the autophosphorylation of CheA and is required for the binding of CheY, the phosphorylation substrate. This complex accounts for 10% of the total number of molecules. {ECO 0000269|PubMed 2068106}. # SUPFAM SSF50341 SSF50341 # eggNOG COG0835 LUCA # eggNOG ENOG4108V3W Bacteria BLAST swissprot:CHEW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CHEW_ECOLI BioCyc ECOL316407:JW1876-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1876-MONOMER BioCyc EcoCyc:CHEW-MONOMER http://biocyc.org/getid?id=EcoCyc:CHEW-MONOMER COG COG0835 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0835 DIP DIP-48236N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48236N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.88.14.6269 http://dx.doi.org/10.1073/pnas.88.14.6269 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M13462 http://www.ebi.ac.uk/ena/data/view/M13462 EMBL M34669 http://www.ebi.ac.uk/ena/data/view/M34669 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0147 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0147 EcoGene EG10149 http://www.ecogene.org/geneInfo.php?eg_id=EG10149 EnsemblBacteria AAC74957 http://www.ensemblgenomes.org/id/AAC74957 EnsemblBacteria AAC74957 http://www.ensemblgenomes.org/id/AAC74957 EnsemblBacteria BAA15703 http://www.ensemblgenomes.org/id/BAA15703 EnsemblBacteria BAA15703 http://www.ensemblgenomes.org/id/BAA15703 EnsemblBacteria BAA15703 http://www.ensemblgenomes.org/id/BAA15703 EnsemblBacteria b1887 http://www.ensemblgenomes.org/id/b1887 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GO_process GO:0006935 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006935 GO_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GO_process GO:0051649 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051649 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0040011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011 GeneID 946400 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946400 HOGENOM HOG000254712 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000254712&db=HOGENOM6 InParanoid P0A964 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A964 IntAct P0A964 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A964* InterPro IPR002545 http://www.ebi.ac.uk/interpro/entry/IPR002545 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW1876 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1876 KEGG_Gene eco:b1887 http://www.genome.jp/dbget-bin/www_bget?eco:b1887 KEGG_Orthology KO:K03408 http://www.genome.jp/dbget-bin/www_bget?KO:K03408 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 KEGG_Pathway ko02030 http://www.genome.jp/kegg-bin/show_pathway?ko02030 MINT MINT-1283783 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1283783 OMA DEEYGVE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DEEYGVE PDB 2HO9 http://www.ebi.ac.uk/pdbe-srv/view/entry/2HO9 PDBsum 2HO9 http://www.ebi.ac.uk/pdbsum/2HO9 PROSITE PS50851 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50851 PSORT swissprot:CHEW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CHEW_ECOLI PSORT-B swissprot:CHEW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CHEW_ECOLI PSORT2 swissprot:CHEW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CHEW_ECOLI Pfam PF01584 http://pfam.xfam.org/family/PF01584 Phobius swissprot:CHEW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CHEW_ECOLI PhylomeDB P0A964 http://phylomedb.org/?seqid=P0A964 ProteinModelPortal P0A964 http://www.proteinmodelportal.org/query/uniprot/P0A964 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2002011 http://www.ncbi.nlm.nih.gov/pubmed/2002011 PubMed 2068106 http://www.ncbi.nlm.nih.gov/pubmed/2068106 PubMed 3510184 http://www.ncbi.nlm.nih.gov/pubmed/3510184 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416401 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416401 RefSeq WP_000147302 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000147302 SMART SM00260 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00260 SMR P0A964 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A964 STRING 511145.b1887 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1887&targetmode=cogs STRING COG0835 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0835&targetmode=cogs SUPFAM SSF50341 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50341 UniProtKB CHEW_ECOLI http://www.uniprot.org/uniprot/CHEW_ECOLI UniProtKB-AC P0A964 http://www.uniprot.org/uniprot/P0A964 charge swissprot:CHEW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CHEW_ECOLI eggNOG COG0835 http://eggnogapi.embl.de/nog_data/html/tree/COG0835 eggNOG ENOG4108V3W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108V3W epestfind swissprot:CHEW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CHEW_ECOLI garnier swissprot:CHEW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CHEW_ECOLI helixturnhelix swissprot:CHEW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CHEW_ECOLI hmoment swissprot:CHEW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CHEW_ECOLI iep swissprot:CHEW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CHEW_ECOLI inforesidue swissprot:CHEW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CHEW_ECOLI octanol swissprot:CHEW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CHEW_ECOLI pepcoil swissprot:CHEW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CHEW_ECOLI pepdigest swissprot:CHEW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CHEW_ECOLI pepinfo swissprot:CHEW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CHEW_ECOLI pepnet swissprot:CHEW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CHEW_ECOLI pepstats swissprot:CHEW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CHEW_ECOLI pepwheel swissprot:CHEW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CHEW_ECOLI pepwindow swissprot:CHEW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CHEW_ECOLI sigcleave swissprot:CHEW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CHEW_ECOLI ## Database ID URL or Descriptions # AltName TDCA_ECOLI Tdc operon transcriptional activator # BioGrid 4262420 7 # EcoGene EG10989 tdcA # FUNCTION TDCA_ECOLI Transcriptional activator for the tdcABCDE operon. {ECO 0000269|PubMed 8413189}. # GO_component GO:0005737 cytoplasm; IDA:EcoCyc. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0000986 bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding; IDA:EcoCyc. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IMP:EcoCyc. # GO_process GO:0070689 L-threonine catabolic process to propionate; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # IntAct P0ACQ7 3 # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR005119 LysR_subst-bd # InterPro IPR011991 WHTH_DNA-bd_dom # KEGG_Brite ko03000 Transcription factors # Organism TDCA_ECOLI Escherichia coli (strain K12) # PATHWAY TDCA_ECOLI Amino-acid degradation; L-threonine degradation via propanoate pathway [regulation]. # PATRIC 32121652 VBIEscCol129921_3212 # PIR S46415 QQECRG # PRINTS PR00039 HTHLYSR # PROSITE PS50931 HTH_LYSR # Pfam PF00126 HTH_1 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TDCA_ECOLI HTH-type transcriptional regulator TdcA # RefSeq NP_417588 NC_000913.3 # RefSeq WP_000104211 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lysR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00253}. # SUPFAM SSF46785 SSF46785 # eggNOG ENOG410811B Bacteria # eggNOG ENOG410XW1S LUCA BLAST swissprot:TDCA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TDCA_ECOLI BioCyc ECOL316407:JW3089-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3089-MONOMER BioCyc EcoCyc:PD00268 http://biocyc.org/getid?id=EcoCyc:PD00268 COG COG0583 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0583 DIP DIP-10968N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10968N DOI 10.1007/BF00425676 http://dx.doi.org/10.1007/BF00425676 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/17.10.3994 http://dx.doi.org/10.1093/nar/17.10.3994 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AJ001620 http://www.ebi.ac.uk/ena/data/view/AJ001620 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M21312 http://www.ebi.ac.uk/ena/data/view/M21312 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X14430 http://www.ebi.ac.uk/ena/data/view/X14430 EchoBASE EB0982 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0982 EcoGene EG10989 http://www.ecogene.org/geneInfo.php?eg_id=EG10989 EnsemblBacteria AAC76153 http://www.ensemblgenomes.org/id/AAC76153 EnsemblBacteria AAC76153 http://www.ensemblgenomes.org/id/AAC76153 EnsemblBacteria BAE77167 http://www.ensemblgenomes.org/id/BAE77167 EnsemblBacteria BAE77167 http://www.ensemblgenomes.org/id/BAE77167 EnsemblBacteria BAE77167 http://www.ensemblgenomes.org/id/BAE77167 EnsemblBacteria b3118 http://www.ensemblgenomes.org/id/b3118 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000986 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000986 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GO_process GO:0070689 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070689 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 947494 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947494 HOGENOM HOG000233526 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000233526&db=HOGENOM6 IntAct P0ACQ7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACQ7* InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW3089 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3089 KEGG_Gene eco:b3118 http://www.genome.jp/dbget-bin/www_bget?eco:b3118 KEGG_Orthology KO:K07592 http://www.genome.jp/dbget-bin/www_bget?KO:K07592 MINT MINT-1310858 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1310858 OMA PWPLIES http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PWPLIES PRINTS PR00039 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00039 PROSITE PS50931 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50931 PSORT swissprot:TDCA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TDCA_ECOLI PSORT-B swissprot:TDCA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TDCA_ECOLI PSORT2 swissprot:TDCA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TDCA_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:TDCA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TDCA_ECOLI PhylomeDB P0ACQ7 http://phylomedb.org/?seqid=P0ACQ7 ProteinModelPortal P0ACQ7 http://www.proteinmodelportal.org/query/uniprot/P0ACQ7 PubMed 10520749 http://www.ncbi.nlm.nih.gov/pubmed/10520749 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2660107 http://www.ncbi.nlm.nih.gov/pubmed/2660107 PubMed 3003533 http://www.ncbi.nlm.nih.gov/pubmed/3003533 PubMed 8413189 http://www.ncbi.nlm.nih.gov/pubmed/8413189 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417588 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417588 RefSeq WP_000104211 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000104211 SMR P0ACQ7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACQ7 STRING 511145.b3118 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3118&targetmode=cogs STRING COG0583 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0583&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB TDCA_ECOLI http://www.uniprot.org/uniprot/TDCA_ECOLI UniProtKB-AC P0ACQ7 http://www.uniprot.org/uniprot/P0ACQ7 charge swissprot:TDCA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TDCA_ECOLI eggNOG ENOG410811B http://eggnogapi.embl.de/nog_data/html/tree/ENOG410811B eggNOG ENOG410XW1S http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XW1S epestfind swissprot:TDCA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TDCA_ECOLI garnier swissprot:TDCA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TDCA_ECOLI helixturnhelix swissprot:TDCA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TDCA_ECOLI hmoment swissprot:TDCA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TDCA_ECOLI iep swissprot:TDCA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TDCA_ECOLI inforesidue swissprot:TDCA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TDCA_ECOLI octanol swissprot:TDCA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TDCA_ECOLI pepcoil swissprot:TDCA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TDCA_ECOLI pepdigest swissprot:TDCA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TDCA_ECOLI pepinfo swissprot:TDCA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TDCA_ECOLI pepnet swissprot:TDCA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TDCA_ECOLI pepstats swissprot:TDCA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TDCA_ECOLI pepwheel swissprot:TDCA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TDCA_ECOLI pepwindow swissprot:TDCA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TDCA_ECOLI sigcleave swissprot:TDCA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TDCA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262554 9 # EcoGene EG12291 yiaW # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR011223 UCP028770 # Organism YIAW_ECOLI Escherichia coli (strain K12) # PATRIC 32122650 VBIEscCol129921_3702 # PIR S47808 S47808 # PIRSF PIRSF028770 UCP028770 # Pfam PF11742 DUF3302 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIAW_ECOLI Inner membrane protein YiaW # RefSeq NP_418044 NC_000913.3 # RefSeq WP_000478195 NZ_LN832404.1 # SIMILARITY To E.coli YibI. {ECO 0000305}. # SUBCELLULAR LOCATION YIAW_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG ENOG4105KK7 Bacteria # eggNOG ENOG4111U7F LUCA BLAST swissprot:YIAW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIAW_ECOLI BioCyc ECOL316407:JW3559-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3559-MONOMER BioCyc EcoCyc:EG12291-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12291-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2199 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2199 EcoGene EG12291 http://www.ecogene.org/geneInfo.php?eg_id=EG12291 EnsemblBacteria AAC76611 http://www.ensemblgenomes.org/id/AAC76611 EnsemblBacteria AAC76611 http://www.ensemblgenomes.org/id/AAC76611 EnsemblBacteria BAE77706 http://www.ensemblgenomes.org/id/BAE77706 EnsemblBacteria BAE77706 http://www.ensemblgenomes.org/id/BAE77706 EnsemblBacteria BAE77706 http://www.ensemblgenomes.org/id/BAE77706 EnsemblBacteria b3587 http://www.ensemblgenomes.org/id/b3587 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 948105 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948105 HOGENOM HOG000279233 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000279233&db=HOGENOM6 InParanoid P0ADK4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADK4 InterPro IPR011223 http://www.ebi.ac.uk/interpro/entry/IPR011223 KEGG_Gene ecj:JW3559 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3559 KEGG_Gene eco:b3587 http://www.genome.jp/dbget-bin/www_bget?eco:b3587 OMA GVIIIHD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GVIIIHD PSORT swissprot:YIAW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIAW_ECOLI PSORT-B swissprot:YIAW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIAW_ECOLI PSORT2 swissprot:YIAW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIAW_ECOLI Pfam PF11742 http://pfam.xfam.org/family/PF11742 Phobius swissprot:YIAW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIAW_ECOLI PhylomeDB P0ADK4 http://phylomedb.org/?seqid=P0ADK4 ProteinModelPortal P0ADK4 http://www.proteinmodelportal.org/query/uniprot/P0ADK4 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418044 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418044 RefSeq WP_000478195 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000478195 SMR P0ADK4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADK4 STRING 511145.b3587 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3587&targetmode=cogs UniProtKB YIAW_ECOLI http://www.uniprot.org/uniprot/YIAW_ECOLI UniProtKB-AC P0ADK4 http://www.uniprot.org/uniprot/P0ADK4 charge swissprot:YIAW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIAW_ECOLI eggNOG ENOG4105KK7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KK7 eggNOG ENOG4111U7F http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111U7F epestfind swissprot:YIAW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIAW_ECOLI garnier swissprot:YIAW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIAW_ECOLI helixturnhelix swissprot:YIAW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIAW_ECOLI hmoment swissprot:YIAW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIAW_ECOLI iep swissprot:YIAW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIAW_ECOLI inforesidue swissprot:YIAW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIAW_ECOLI octanol swissprot:YIAW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIAW_ECOLI pepcoil swissprot:YIAW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIAW_ECOLI pepdigest swissprot:YIAW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIAW_ECOLI pepinfo swissprot:YIAW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIAW_ECOLI pepnet swissprot:YIAW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIAW_ECOLI pepstats swissprot:YIAW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIAW_ECOLI pepwheel swissprot:YIAW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIAW_ECOLI pepwindow swissprot:YIAW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIAW_ECOLI sigcleave swissprot:YIAW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIAW_ECOLI ## Database ID URL or Descriptions # BioGrid 4261130 16 # CDD cd01392 HTH_LacI # EcoGene EG10557 malI # FUNCTION MALI_ECOLI Repressor for the malX and malY genes. Also regulates its own expression. Binds maltose as an inducer. {ECO 0000269|PubMed 1856179}. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IMP:EcoCyc. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.260.40 -; 1. # IntAct P18811 6 # InterPro IPR000843 HTH_LacI # InterPro IPR001761 Peripla_BP/Lac1_sug-bd_dom # InterPro IPR010982 Lambda_DNA-bd_dom # InterPro IPR028082 Peripla_BP_I # KEGG_Brite ko03000 Transcription factors # Organism MALI_ECOLI Escherichia coli (strain K12) # PATRIC 32118542 VBIEscCol129921_1691 # PIR F64918 RPECML # PROSITE PS00356 HTH_LACI_1 # PROSITE PS50932 HTH_LACI_2 # Pfam PF00356 LacI # Pfam PF00532 Peripla_BP_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MALI_ECOLI Maltose regulon regulatory protein MalI # RefSeq NP_416137 NC_000913.3 # RefSeq WP_000179510 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lacI-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00111}. # SMART SM00354 HTH_LACI # SUPFAM SSF47413 SSF47413 # SUPFAM SSF53822 SSF53822 # eggNOG COG1609 LUCA # eggNOG ENOG4107P2S Bacteria BLAST swissprot:MALI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MALI_ECOLI BioCyc ECOL316407:JW1612-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1612-MONOMER BioCyc EcoCyc:PD00361 http://biocyc.org/getid?id=EcoCyc:PD00361 COG COG1609 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1609 DIP DIP-10143N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10143N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M28539 http://www.ebi.ac.uk/ena/data/view/M28539 EMBL M60722 http://www.ebi.ac.uk/ena/data/view/M60722 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0552 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0552 EcoGene EG10557 http://www.ecogene.org/geneInfo.php?eg_id=EG10557 EnsemblBacteria AAC74692 http://www.ensemblgenomes.org/id/AAC74692 EnsemblBacteria AAC74692 http://www.ensemblgenomes.org/id/AAC74692 EnsemblBacteria BAA15371 http://www.ensemblgenomes.org/id/BAA15371 EnsemblBacteria BAA15371 http://www.ensemblgenomes.org/id/BAA15371 EnsemblBacteria BAA15371 http://www.ensemblgenomes.org/id/BAA15371 EnsemblBacteria b1620 http://www.ensemblgenomes.org/id/b1620 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.260.40 http://www.cathdb.info/version/latest/superfamily/1.10.260.40 GeneID 947104 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947104 HOGENOM HOG000220179 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220179&db=HOGENOM6 InParanoid P18811 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P18811 IntAct P18811 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P18811* InterPro IPR000843 http://www.ebi.ac.uk/interpro/entry/IPR000843 InterPro IPR001761 http://www.ebi.ac.uk/interpro/entry/IPR001761 InterPro IPR010982 http://www.ebi.ac.uk/interpro/entry/IPR010982 InterPro IPR028082 http://www.ebi.ac.uk/interpro/entry/IPR028082 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW1612 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1612 KEGG_Gene eco:b1620 http://www.genome.jp/dbget-bin/www_bget?eco:b1620 KEGG_Orthology KO:K16136 http://www.genome.jp/dbget-bin/www_bget?KO:K16136 OMA WVLECAS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WVLECAS PROSITE PS00356 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00356 PROSITE PS50932 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50932 PSORT swissprot:MALI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MALI_ECOLI PSORT-B swissprot:MALI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MALI_ECOLI PSORT2 swissprot:MALI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MALI_ECOLI Pfam PF00356 http://pfam.xfam.org/family/PF00356 Pfam PF00532 http://pfam.xfam.org/family/PF00532 Phobius swissprot:MALI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MALI_ECOLI PhylomeDB P18811 http://phylomedb.org/?seqid=P18811 ProteinModelPortal P18811 http://www.proteinmodelportal.org/query/uniprot/P18811 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1856179 http://www.ncbi.nlm.nih.gov/pubmed/1856179 PubMed 2670898 http://www.ncbi.nlm.nih.gov/pubmed/2670898 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416137 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416137 RefSeq WP_000179510 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000179510 SMART SM00354 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00354 SMR P18811 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P18811 STRING 511145.b1620 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1620&targetmode=cogs STRING COG1609 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1609&targetmode=cogs SUPFAM SSF47413 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47413 SUPFAM SSF53822 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822 UniProtKB MALI_ECOLI http://www.uniprot.org/uniprot/MALI_ECOLI UniProtKB-AC P18811 http://www.uniprot.org/uniprot/P18811 charge swissprot:MALI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MALI_ECOLI eggNOG COG1609 http://eggnogapi.embl.de/nog_data/html/tree/COG1609 eggNOG ENOG4107P2S http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107P2S epestfind swissprot:MALI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MALI_ECOLI garnier swissprot:MALI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MALI_ECOLI helixturnhelix swissprot:MALI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MALI_ECOLI hmoment swissprot:MALI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MALI_ECOLI iep swissprot:MALI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MALI_ECOLI inforesidue swissprot:MALI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MALI_ECOLI octanol swissprot:MALI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MALI_ECOLI pepcoil swissprot:MALI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MALI_ECOLI pepdigest swissprot:MALI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MALI_ECOLI pepinfo swissprot:MALI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MALI_ECOLI pepnet swissprot:MALI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MALI_ECOLI pepstats swissprot:MALI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MALI_ECOLI pepwheel swissprot:MALI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MALI_ECOLI pepwindow swissprot:MALI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MALI_ECOLI sigcleave swissprot:MALI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MALI_ECOLI ## Database ID URL or Descriptions # BRENDA 2.7.13 2026 # BioGrid 4259459 14 # CATALYTIC ACTIVITY QSEC_ECOLI ATP + protein L-histidine = ADP + protein N- phospho-L-histidine. # EcoGene EG13027 qseC # FUNCTION QSEC_ECOLI Member of a two-component regulatory system QseB/QseC. Activates the flagella regulon by activating transcription of FlhDC. May activate QseB by phosphorylation. {ECO 0000269|PubMed 11929534}. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0000155 phosphorelay sensor kinase activity; IEA:InterPro. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005622 intracellular # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # Gene3D 1.10.287.130 -; 1. # Gene3D 3.30.565.10 -; 1. # INDUCTION By the signal autoinducer AI-2, through MqsR. {ECO:0000269|PubMed 16352847}. # IntAct P40719 6 # InterPro IPR003594 HATPase_C # InterPro IPR003661 HisK_dim/P # InterPro IPR004358 Sig_transdc_His_kin-like_C # InterPro IPR005467 His_kinase_dom # InterPro IPR013727 2CSK_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01001 Protein kinases # KEGG_Brite ko02022 M00453 QseC-QseB (quorum sensing) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # Organism QSEC_ECOLI Escherichia coli (strain K12) # PATRIC 32121464 VBIEscCol129921_3119 # PDB 2KSE NMR; -; A=2-185 # PDB 3JZ3 X-ray; 2.50 A; A/B=236-449 # PIR H65089 H65089 # PRINTS PR00344 BCTRLSENSOR # PROSITE PS50109 HIS_KIN # Pfam PF00512 HisKA # Pfam PF02518 HATPase_c # Pfam PF08521 2CSK_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName QSEC_ECOLI Sensor protein QseC # RefSeq NP_417498 NC_000913.3 # RefSeq WP_000673402 NZ_LN832404.1 # SIMILARITY Contains 1 histidine kinase domain. {ECO:0000255|PROSITE-ProRule PRU00107}. # SMART SM00387 HATPase_c # SMART SM00388 HisKA # SUBCELLULAR LOCATION QSEC_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF47384 SSF47384 # SUPFAM SSF55874 SSF55874 # eggNOG ENOG4105DHQ Bacteria # eggNOG ENOG410XS4R LUCA BLAST swissprot:QSEC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:QSEC_ECOLI BioCyc ECOL316407:JW2994-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2994-MONOMER BioCyc EcoCyc:EG12658-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12658-MONOMER COG COG0642 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0642 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2002.02803.x http://dx.doi.org/10.1046/j.1365-2958.2002.02803.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.188.1.305-316.2006 http://dx.doi.org/10.1128/JB.188.1.305-316.2006 EC_number EC:2.7.13.3 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.13.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18656 http://www.ebi.ac.uk/ena/data/view/U18656 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 ENZYME 2.7.13.3 http://enzyme.expasy.org/EC/2.7.13.3 EchoBASE EB2845 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2845 EcoGene EG13027 http://www.ecogene.org/geneInfo.php?eg_id=EG13027 EnsemblBacteria AAC76062 http://www.ensemblgenomes.org/id/AAC76062 EnsemblBacteria AAC76062 http://www.ensemblgenomes.org/id/AAC76062 EnsemblBacteria BAE77082 http://www.ensemblgenomes.org/id/BAE77082 EnsemblBacteria BAE77082 http://www.ensemblgenomes.org/id/BAE77082 EnsemblBacteria BAE77082 http://www.ensemblgenomes.org/id/BAE77082 EnsemblBacteria b3026 http://www.ensemblgenomes.org/id/b3026 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0000155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000155 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 1.10.287.130 http://www.cathdb.info/version/latest/superfamily/1.10.287.130 Gene3D 3.30.565.10 http://www.cathdb.info/version/latest/superfamily/3.30.565.10 GeneID 947174 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947174 HOGENOM HOG000223178 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000223178&db=HOGENOM6 InParanoid P40719 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P40719 IntAct P40719 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P40719* IntEnz 2.7.13.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.13.3 InterPro IPR003594 http://www.ebi.ac.uk/interpro/entry/IPR003594 InterPro IPR003661 http://www.ebi.ac.uk/interpro/entry/IPR003661 InterPro IPR004358 http://www.ebi.ac.uk/interpro/entry/IPR004358 InterPro IPR005467 http://www.ebi.ac.uk/interpro/entry/IPR005467 InterPro IPR013727 http://www.ebi.ac.uk/interpro/entry/IPR013727 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01001 http://www.genome.jp/dbget-bin/www_bget?ko01001 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW2994 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2994 KEGG_Gene eco:b3026 http://www.genome.jp/dbget-bin/www_bget?eco:b3026 KEGG_Orthology KO:K07645 http://www.genome.jp/dbget-bin/www_bget?KO:K07645 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA FGQMWIW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FGQMWIW PDB 2KSE http://www.ebi.ac.uk/pdbe-srv/view/entry/2KSE PDB 3JZ3 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JZ3 PDBsum 2KSE http://www.ebi.ac.uk/pdbsum/2KSE PDBsum 3JZ3 http://www.ebi.ac.uk/pdbsum/3JZ3 PRINTS PR00344 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00344 PROSITE PS50109 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50109 PSORT swissprot:QSEC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:QSEC_ECOLI PSORT-B swissprot:QSEC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:QSEC_ECOLI PSORT2 swissprot:QSEC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:QSEC_ECOLI Pfam PF00512 http://pfam.xfam.org/family/PF00512 Pfam PF02518 http://pfam.xfam.org/family/PF02518 Pfam PF08521 http://pfam.xfam.org/family/PF08521 Phobius swissprot:QSEC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:QSEC_ECOLI PhylomeDB P40719 http://phylomedb.org/?seqid=P40719 ProteinModelPortal P40719 http://www.proteinmodelportal.org/query/uniprot/P40719 PubMed 11929534 http://www.ncbi.nlm.nih.gov/pubmed/11929534 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16352847 http://www.ncbi.nlm.nih.gov/pubmed/16352847 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417498 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417498 RefSeq WP_000673402 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000673402 SMART SM00387 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00387 SMART SM00388 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00388 SMR P40719 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P40719 STRING 511145.b3026 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3026&targetmode=cogs STRING COG0642 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0642&targetmode=cogs SUPFAM SSF47384 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47384 SUPFAM SSF55874 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55874 UniProtKB QSEC_ECOLI http://www.uniprot.org/uniprot/QSEC_ECOLI UniProtKB-AC P40719 http://www.uniprot.org/uniprot/P40719 charge swissprot:QSEC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:QSEC_ECOLI eggNOG ENOG4105DHQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DHQ eggNOG ENOG410XS4R http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XS4R epestfind swissprot:QSEC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:QSEC_ECOLI garnier swissprot:QSEC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:QSEC_ECOLI helixturnhelix swissprot:QSEC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:QSEC_ECOLI hmoment swissprot:QSEC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:QSEC_ECOLI iep swissprot:QSEC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:QSEC_ECOLI inforesidue swissprot:QSEC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:QSEC_ECOLI octanol swissprot:QSEC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:QSEC_ECOLI pepcoil swissprot:QSEC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:QSEC_ECOLI pepdigest swissprot:QSEC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:QSEC_ECOLI pepinfo swissprot:QSEC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:QSEC_ECOLI pepnet swissprot:QSEC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:QSEC_ECOLI pepstats swissprot:QSEC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:QSEC_ECOLI pepwheel swissprot:QSEC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:QSEC_ECOLI pepwindow swissprot:QSEC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:QSEC_ECOLI sigcleave swissprot:QSEC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:QSEC_ECOLI ## Database ID URL or Descriptions # BioGrid 4261018 15 # CATALYTIC ACTIVITY DCOS_ECOLI L-ornithine = putrescine + CO(2). # CDD cd00615 Orn_deC_like # COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI 597326; # EcoGene EG10964 speF # GO_component GO:0005737 cytoplasm; IEA:InterPro. # GO_function GO:0004586 ornithine decarboxylase activity; IDA:EcoCyc. # GO_function GO:0030170 pyridoxal phosphate binding; IDA:EcoCyc. # GO_process GO:0008295 spermidine biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0033387 putrescine biosynthetic process from ornithine; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.50.220 -; 1. # Gene3D 3.40.640.10 -; 1. # Gene3D 3.90.100.10 -; 1. # Gene3D 3.90.1150.10 -; 1. # INDUCTION DCOS_ECOLI By low environmental pH. # IntAct P24169 4 # InterPro IPR000310 Orn/Lys/Arg_deCO2ase_major_dom # InterPro IPR005308 OKR_de-COase_N # InterPro IPR008286 Prn/Lys/Arg_de-COase_C # InterPro IPR011006 CheY-like_superfamily # InterPro IPR011193 Orn/lys/arg_de-COase # InterPro IPR015421 PyrdxlP-dep_Trfase_major_sub1 # InterPro IPR015422 PyrdxlP-dep_Trfase_major_sub2 # InterPro IPR015424 PyrdxlP-dep_Trfase # InterPro IPR027464 Ornithine_deCO2ase_N # InterPro IPR027568 ODC_inducible # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00330 Arginine and proline metabolism # KEGG_Pathway ko00480 Glutathione metabolism # Organism DCOS_ECOLI Escherichia coli (strain K12) # PATHWAY Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine step 1/1. # PATRIC 32116581 VBIEscCol129921_0723 # PIR A40839 A40839 # PIRSF PIRSF009393 Orn_decarb # PROSITE PS00703 OKR_DC_1 # Pfam PF01276 OKR_DC_1 # Pfam PF03709 OKR_DC_1_N # Pfam PF03711 OKR_DC_1_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DCOS_ECOLI Ornithine decarboxylase, inducible # RefSeq NP_415220 NC_000913.3 # RefSeq WP_000040195 NZ_LN832404.1 # SIMILARITY Belongs to the Orn/Lys/Arg decarboxylase class-I family. {ECO 0000305}. # SUPFAM SSF52172 SSF52172 # SUPFAM SSF53383 SSF53383 # SUPFAM SSF55904 SSF55904 # TIGRFAMs TIGR04301 ODC_inducible # UniPathway UPA00535 UER00288 # eggNOG COG1982 LUCA # eggNOG ENOG4105CXN Bacteria BLAST swissprot:DCOS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DCOS_ECOLI BioCyc ECOL316407:JW0680-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0680-MONOMER BioCyc EcoCyc:ORNDECARBOXDEG-MONOMER http://biocyc.org/getid?id=EcoCyc:ORNDECARBOXDEG-MONOMER BioCyc MetaCyc:ORNDECARBOXDEG-MONOMER http://biocyc.org/getid?id=MetaCyc:ORNDECARBOXDEG-MONOMER COG COG1982 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1982 DIP DIP-154N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-154N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.1.1.17 http://www.genome.jp/dbget-bin/www_bget?EC:4.1.1.17 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M64495 http://www.ebi.ac.uk/ena/data/view/M64495 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 4.1.1.17 http://enzyme.expasy.org/EC/4.1.1.17 EchoBASE EB0957 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0957 EcoGene EG10964 http://www.ecogene.org/geneInfo.php?eg_id=EG10964 EnsemblBacteria AAC73787 http://www.ensemblgenomes.org/id/AAC73787 EnsemblBacteria AAC73787 http://www.ensemblgenomes.org/id/AAC73787 EnsemblBacteria BAA35349 http://www.ensemblgenomes.org/id/BAA35349 EnsemblBacteria BAA35349 http://www.ensemblgenomes.org/id/BAA35349 EnsemblBacteria BAA35349 http://www.ensemblgenomes.org/id/BAA35349 EnsemblBacteria b0693 http://www.ensemblgenomes.org/id/b0693 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004586 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004586 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_process GO:0008295 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008295 GO_process GO:0033387 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033387 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.50.220 http://www.cathdb.info/version/latest/superfamily/3.40.50.220 Gene3D 3.40.640.10 http://www.cathdb.info/version/latest/superfamily/3.40.640.10 Gene3D 3.90.100.10 http://www.cathdb.info/version/latest/superfamily/3.90.100.10 Gene3D 3.90.1150.10 http://www.cathdb.info/version/latest/superfamily/3.90.1150.10 GeneID 945297 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945297 HOGENOM HOG000164393 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000164393&db=HOGENOM6 InParanoid P24169 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P24169 IntAct P24169 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P24169* IntEnz 4.1.1.17 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.1.17 InterPro IPR000310 http://www.ebi.ac.uk/interpro/entry/IPR000310 InterPro IPR005308 http://www.ebi.ac.uk/interpro/entry/IPR005308 InterPro IPR008286 http://www.ebi.ac.uk/interpro/entry/IPR008286 InterPro IPR011006 http://www.ebi.ac.uk/interpro/entry/IPR011006 InterPro IPR011193 http://www.ebi.ac.uk/interpro/entry/IPR011193 InterPro IPR015421 http://www.ebi.ac.uk/interpro/entry/IPR015421 InterPro IPR015422 http://www.ebi.ac.uk/interpro/entry/IPR015422 InterPro IPR015424 http://www.ebi.ac.uk/interpro/entry/IPR015424 InterPro IPR027464 http://www.ebi.ac.uk/interpro/entry/IPR027464 InterPro IPR027568 http://www.ebi.ac.uk/interpro/entry/IPR027568 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0680 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0680 KEGG_Gene eco:b0693 http://www.genome.jp/dbget-bin/www_bget?eco:b0693 KEGG_Orthology KO:K01581 http://www.genome.jp/dbget-bin/www_bget?KO:K01581 KEGG_Pathway ko00330 http://www.genome.jp/kegg-bin/show_pathway?ko00330 KEGG_Pathway ko00480 http://www.genome.jp/kegg-bin/show_pathway?ko00480 KEGG_Reaction rn:R00670 http://www.genome.jp/dbget-bin/www_bget?rn:R00670 OMA HIKGQPR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HIKGQPR PROSITE PS00703 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00703 PSORT swissprot:DCOS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DCOS_ECOLI PSORT-B swissprot:DCOS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DCOS_ECOLI PSORT2 swissprot:DCOS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DCOS_ECOLI Pfam PF01276 http://pfam.xfam.org/family/PF01276 Pfam PF03709 http://pfam.xfam.org/family/PF03709 Pfam PF03711 http://pfam.xfam.org/family/PF03711 Phobius swissprot:DCOS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DCOS_ECOLI PhylomeDB P24169 http://phylomedb.org/?seqid=P24169 ProteinModelPortal P24169 http://www.proteinmodelportal.org/query/uniprot/P24169 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1939141 http://www.ncbi.nlm.nih.gov/pubmed/1939141 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415220 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415220 RefSeq WP_000040195 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000040195 SMR P24169 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P24169 STRING 511145.b0693 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0693&targetmode=cogs STRING COG1982 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1982&targetmode=cogs SUPFAM SSF52172 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52172 SUPFAM SSF53383 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53383 SUPFAM SSF55904 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55904 TIGRFAMs TIGR04301 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR04301 UniProtKB DCOS_ECOLI http://www.uniprot.org/uniprot/DCOS_ECOLI UniProtKB-AC P24169 http://www.uniprot.org/uniprot/P24169 charge swissprot:DCOS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DCOS_ECOLI eggNOG COG1982 http://eggnogapi.embl.de/nog_data/html/tree/COG1982 eggNOG ENOG4105CXN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CXN epestfind swissprot:DCOS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DCOS_ECOLI garnier swissprot:DCOS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DCOS_ECOLI helixturnhelix swissprot:DCOS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DCOS_ECOLI hmoment swissprot:DCOS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DCOS_ECOLI iep swissprot:DCOS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DCOS_ECOLI inforesidue swissprot:DCOS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DCOS_ECOLI octanol swissprot:DCOS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DCOS_ECOLI pepcoil swissprot:DCOS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DCOS_ECOLI pepdigest swissprot:DCOS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DCOS_ECOLI pepinfo swissprot:DCOS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DCOS_ECOLI pepnet swissprot:DCOS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DCOS_ECOLI pepstats swissprot:DCOS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DCOS_ECOLI pepwheel swissprot:DCOS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DCOS_ECOLI pepwindow swissprot:DCOS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DCOS_ECOLI sigcleave swissprot:DCOS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DCOS_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=5 mM for bromoacetate {ECO 0000269|PubMed:20921376}; # BioGrid 4262824 11 # CATALYTIC ACTIVITY RX + glutathione = HX + R-S-glutathione. {ECO:0000269|PubMed 20921376}. # DISRUPTION PHENOTYPE Mutants are hypersensitive to bromoacetate. {ECO:0000269|PubMed 20921376}. # EcoGene EG13481 gstB # FUNCTION GSTB_ECOLI Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes the glutathione-dependent dehalogenation of bromoacetate. {ECO 0000269|PubMed 20921376}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004364 glutathione transferase activity; IDA:EcoCyc. # GO_function GO:0030611 arsenate reductase activity; IDA:EcoCyc. # GO_process GO:0006749 glutathione metabolic process; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.20.1050.10 -; 1. # Gene3D 3.40.30.10 -; 1. # INTERACTION GSTB_ECOLI Self; NbExp=2; IntAct=EBI-1120568, EBI-1120568; P06987 hisB; NbExp=4; IntAct=EBI-1120568, EBI-1126930; # IntAct P0ACA7 2 # InterPro IPR004045 Glutathione_S-Trfase_N # InterPro IPR004046 GST_C # InterPro IPR010987 Glutathione-S-Trfase_C-like # InterPro IPR012336 Thioredoxin-like_fold # Organism GSTB_ECOLI Escherichia coli (strain K12) # PATRIC 32116879 VBIEscCol129921_0865 # PROSITE PS50404 GST_NTER # PROSITE PS50405 GST_CTER # Pfam PF00043 GST_C # Pfam PF02798 GST_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GSTB_ECOLI Glutathione S-transferase GstB # RefSeq NP_415359 NC_000913.3 # RefSeq WP_001295292 NZ_LN832404.1 # SIMILARITY Belongs to the GST superfamily. {ECO 0000305}. # SIMILARITY Contains 1 GST C-terminal domain. {ECO 0000305}. # SIMILARITY Contains 1 GST N-terminal domain. {ECO 0000305}. # SUPFAM SSF47616 SSF47616 # SUPFAM SSF52833 SSF52833 # eggNOG COG0625 LUCA # eggNOG ENOG4108TGY Bacteria BLAST swissprot:GSTB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GSTB_ECOLI BioCyc ECOL316407:JW0822-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0822-MONOMER BioCyc EcoCyc:G6438-MONOMER http://biocyc.org/getid?id=EcoCyc:G6438-MONOMER BioCyc MetaCyc:G6438-MONOMER http://biocyc.org/getid?id=MetaCyc:G6438-MONOMER DIP DIP-48220N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48220N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.1007559107 http://dx.doi.org/10.1073/pnas.1007559107 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.5.1.18 http://www.genome.jp/dbget-bin/www_bget?EC:2.5.1.18 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.5.1.18 http://enzyme.expasy.org/EC/2.5.1.18 EchoBASE EB3254 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3254 EcoGene EG13481 http://www.ecogene.org/geneInfo.php?eg_id=EG13481 EnsemblBacteria AAC73925 http://www.ensemblgenomes.org/id/AAC73925 EnsemblBacteria AAC73925 http://www.ensemblgenomes.org/id/AAC73925 EnsemblBacteria BAA35541 http://www.ensemblgenomes.org/id/BAA35541 EnsemblBacteria BAA35541 http://www.ensemblgenomes.org/id/BAA35541 EnsemblBacteria BAA35541 http://www.ensemblgenomes.org/id/BAA35541 EnsemblBacteria b0838 http://www.ensemblgenomes.org/id/b0838 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004364 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004364 GO_function GO:0030611 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030611 GO_process GO:0006749 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006749 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016765 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.20.1050.10 http://www.cathdb.info/version/latest/superfamily/1.20.1050.10 Gene3D 3.40.30.10 http://www.cathdb.info/version/latest/superfamily/3.40.30.10 GeneID 945469 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945469 HOGENOM HOG000125757 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125757&db=HOGENOM6 InParanoid P0ACA7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACA7 IntAct P0ACA7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACA7* IntEnz 2.5.1.18 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.5.1.18 InterPro IPR004045 http://www.ebi.ac.uk/interpro/entry/IPR004045 InterPro IPR004046 http://www.ebi.ac.uk/interpro/entry/IPR004046 InterPro IPR010987 http://www.ebi.ac.uk/interpro/entry/IPR010987 InterPro IPR012336 http://www.ebi.ac.uk/interpro/entry/IPR012336 KEGG_Gene ecj:JW0822 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0822 KEGG_Gene eco:b0838 http://www.genome.jp/dbget-bin/www_bget?eco:b0838 OMA DIAFAPW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DIAFAPW PROSITE PS50404 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50404 PROSITE PS50405 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50405 PSORT swissprot:GSTB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GSTB_ECOLI PSORT-B swissprot:GSTB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GSTB_ECOLI PSORT2 swissprot:GSTB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GSTB_ECOLI Pfam PF00043 http://pfam.xfam.org/family/PF00043 Pfam PF02798 http://pfam.xfam.org/family/PF02798 Phobius swissprot:GSTB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GSTB_ECOLI PhylomeDB P0ACA7 http://phylomedb.org/?seqid=P0ACA7 ProteinModelPortal P0ACA7 http://www.proteinmodelportal.org/query/uniprot/P0ACA7 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20921376 http://www.ncbi.nlm.nih.gov/pubmed/20921376 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415359 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415359 RefSeq WP_001295292 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295292 SMR P0ACA7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACA7 STRING 511145.b0838 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0838&targetmode=cogs SUPFAM SSF47616 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47616 SUPFAM SSF52833 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52833 UniProtKB GSTB_ECOLI http://www.uniprot.org/uniprot/GSTB_ECOLI UniProtKB-AC P0ACA7 http://www.uniprot.org/uniprot/P0ACA7 charge swissprot:GSTB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GSTB_ECOLI eggNOG COG0625 http://eggnogapi.embl.de/nog_data/html/tree/COG0625 eggNOG ENOG4108TGY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108TGY epestfind swissprot:GSTB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GSTB_ECOLI garnier swissprot:GSTB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GSTB_ECOLI helixturnhelix swissprot:GSTB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GSTB_ECOLI hmoment swissprot:GSTB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GSTB_ECOLI iep swissprot:GSTB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GSTB_ECOLI inforesidue swissprot:GSTB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GSTB_ECOLI octanol swissprot:GSTB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GSTB_ECOLI pepcoil swissprot:GSTB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GSTB_ECOLI pepdigest swissprot:GSTB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GSTB_ECOLI pepinfo swissprot:GSTB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GSTB_ECOLI pepnet swissprot:GSTB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GSTB_ECOLI pepstats swissprot:GSTB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GSTB_ECOLI pepwheel swissprot:GSTB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GSTB_ECOLI pepwindow swissprot:GSTB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GSTB_ECOLI sigcleave swissprot:GSTB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GSTB_ECOLI ## Database ID URL or Descriptions # BioGrid 4263189 252 # CATALYTIC ACTIVITY AMIB_ECOLI Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. # CDD cd02696 MurNAc-LAA # EcoGene EG11363 amiB # FUNCTION AMIB_ECOLI Cell-wall hydrolase involved in septum cleavage during cell division. Can also act as powerful autolysin in the presence of murein synthesis inhibitors. {ECO 0000269|PubMed 11454209, ECO 0000269|PubMed 18390656}. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IBA:GO_Central. # GO_function GO:0008745 N-acetylmuramoyl-L-alanine amidase activity; IDA:EcoCyc. # GO_process GO:0009253 peptidoglycan catabolic process; IEA:InterPro. # GO_process GO:0043093 FtsZ-dependent cytokinesis; IDA:EcoCyc. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 3.40.630.40 -; 2. # InterPro IPR002508 MurNAc-LAA_cat # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03036 Chromosome # Organism AMIB_ECOLI Escherichia coli (strain K12) # PATRIC 32123911 VBIEscCol129921_4300 # PIR S41741 S41741 # Pfam PF01520 Amidase_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AMIB_ECOLI N-acetylmuramoyl-L-alanine amidase AmiB # RefSeq NP_418590 NC_000913.3 # RefSeq WP_000990333 NZ_LN832404.1 # SIMILARITY Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family. {ECO 0000305}. # SMART SM00646 Ami_3 # SUBCELLULAR LOCATION AMIB_ECOLI Periplasm {ECO 0000250}. # eggNOG COG0860 LUCA # eggNOG ENOG4105C5C Bacteria BLAST swissprot:AMIB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AMIB_ECOLI BioCyc ECOL316407:JW4127-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4127-MONOMER BioCyc EcoCyc:NACMURLALAAMI2-MONOMER http://biocyc.org/getid?id=EcoCyc:NACMURLALAAMI2-MONOMER BioCyc MetaCyc:NACMURLALAAMI2-MONOMER http://biocyc.org/getid?id=MetaCyc:NACMURLALAAMI2-MONOMER COG COG0860 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0860 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2001.02499.x http://dx.doi.org/10.1046/j.1365-2958.2001.02499.x DOI 10.1093/nar/20.9.2379 http://dx.doi.org/10.1093/nar/20.9.2379 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1111/j.1365-2958.1994.tb00300.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb00300.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00207-08 http://dx.doi.org/10.1128/JB.00207-08 EC_number EC:3.5.1.28 http://www.genome.jp/dbget-bin/www_bget?EC:3.5.1.28 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19346 http://www.ebi.ac.uk/ena/data/view/L19346 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL Z11831 http://www.ebi.ac.uk/ena/data/view/Z11831 ENZYME 3.5.1.28 http://enzyme.expasy.org/EC/3.5.1.28 EchoBASE EB1338 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1338 EcoGene EG11363 http://www.ecogene.org/geneInfo.php?eg_id=EG11363 EnsemblBacteria AAC77126 http://www.ensemblgenomes.org/id/AAC77126 EnsemblBacteria AAC77126 http://www.ensemblgenomes.org/id/AAC77126 EnsemblBacteria BAE78170 http://www.ensemblgenomes.org/id/BAE78170 EnsemblBacteria BAE78170 http://www.ensemblgenomes.org/id/BAE78170 EnsemblBacteria BAE78170 http://www.ensemblgenomes.org/id/BAE78170 EnsemblBacteria b4169 http://www.ensemblgenomes.org/id/b4169 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0008745 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008745 GO_process GO:0009253 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009253 GO_process GO:0043093 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043093 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 3.40.630.40 http://www.cathdb.info/version/latest/superfamily/3.40.630.40 GeneID 948683 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948683 HOGENOM HOG000263828 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000263828&db=HOGENOM6 InParanoid P26365 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P26365 IntEnz 3.5.1.28 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.1.28 InterPro IPR002508 http://www.ebi.ac.uk/interpro/entry/IPR002508 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene ecj:JW4127 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4127 KEGG_Gene eco:b4169 http://www.genome.jp/dbget-bin/www_bget?eco:b4169 KEGG_Orthology KO:K01448 http://www.genome.jp/dbget-bin/www_bget?KO:K01448 KEGG_Reaction rn:R04112 http://www.genome.jp/dbget-bin/www_bget?rn:R04112 OMA MTRDGDY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MTRDGDY PSORT swissprot:AMIB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AMIB_ECOLI PSORT-B swissprot:AMIB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AMIB_ECOLI PSORT2 swissprot:AMIB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AMIB_ECOLI Pfam PF01520 http://pfam.xfam.org/family/PF01520 Phobius swissprot:AMIB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AMIB_ECOLI PhylomeDB P26365 http://phylomedb.org/?seqid=P26365 ProteinModelPortal P26365 http://www.proteinmodelportal.org/query/uniprot/P26365 PubMed 11454209 http://www.ncbi.nlm.nih.gov/pubmed/11454209 PubMed 1594459 http://www.ncbi.nlm.nih.gov/pubmed/1594459 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18390656 http://www.ncbi.nlm.nih.gov/pubmed/18390656 PubMed 7511774 http://www.ncbi.nlm.nih.gov/pubmed/7511774 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418590 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418590 RefSeq WP_000990333 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000990333 SMART SM00646 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00646 SMR P26365 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P26365 STRING 511145.b4169 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4169&targetmode=cogs STRING COG0860 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0860&targetmode=cogs UniProtKB AMIB_ECOLI http://www.uniprot.org/uniprot/AMIB_ECOLI UniProtKB-AC P26365 http://www.uniprot.org/uniprot/P26365 charge swissprot:AMIB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AMIB_ECOLI eggNOG COG0860 http://eggnogapi.embl.de/nog_data/html/tree/COG0860 eggNOG ENOG4105C5C http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C5C epestfind swissprot:AMIB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AMIB_ECOLI garnier swissprot:AMIB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AMIB_ECOLI helixturnhelix swissprot:AMIB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AMIB_ECOLI hmoment swissprot:AMIB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AMIB_ECOLI iep swissprot:AMIB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AMIB_ECOLI inforesidue swissprot:AMIB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AMIB_ECOLI octanol swissprot:AMIB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AMIB_ECOLI pepcoil swissprot:AMIB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AMIB_ECOLI pepdigest swissprot:AMIB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AMIB_ECOLI pepinfo swissprot:AMIB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AMIB_ECOLI pepnet swissprot:AMIB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AMIB_ECOLI pepstats swissprot:AMIB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AMIB_ECOLI pepwheel swissprot:AMIB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AMIB_ECOLI pepwindow swissprot:AMIB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AMIB_ECOLI sigcleave swissprot:AMIB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AMIB_ECOLI ## Database ID URL or Descriptions # BioGrid 4262264 16 # EcoGene EG10771 proV # FUNCTION PROV_ECOLI Part of the ProU ABC transporter complex involved in glycine betaine and proline betaine uptake (PubMed 3305496, PubMed 7898450, PubMed 23249124). Probably responsible for energy coupling to the transport system (Probable). {ECO 0000269|PubMed 23249124, ECO 0000269|PubMed 3305496, ECO 0000269|PubMed 7898450, ECO 0000305}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0015171 amino acid transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0016887 ATPase activity; IEA:InterPro. # GO_process GO:0031460 glycine betaine transport; IEA:InterPro. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # Gene3D 3.40.50.300 -; 1. # INTERACTION PROV_ECOLI P14176 proW; NbExp=2; IntAct=EBI-546797, EBI-8794761; # IntAct P14175 6 # InterPro IPR000644 CBS_dom # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR005892 Gly-betaine_transp_ATP-bd # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00208 Glycine betaine/proline transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism PROV_ECOLI Escherichia coli (strain K12) # PATRIC 32120744 VBIEscCol129921_2769 # PIR JS0128 BVECPV # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # PROSITE PS51371 CBS; 2 # Pfam PF00005 ABC_tran # Pfam PF00571 CBS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Glycine betaine/proline betaine transport system ATP-binding protein ProV {ECO 0000305} # RefSeq NP_417163 NC_000913.3 # RefSeq WP_000985494 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule PRU00434}. # SIMILARITY Contains 2 CBS domains. {ECO:0000255|PROSITE- ProRule PRU00703}. # SMART SM00382 AAA # SUBCELLULAR LOCATION PROV_ECOLI Cell inner membrane {ECO 0000269|PubMed 16079137}; Peripheral membrane protein {ECO 0000269|PubMed 16079137}. # SUBUNIT The complex is composed of two ATP-binding proteins (ProV), two transmembrane proteins (ProW) and a solute-binding protein (ProX). {ECO:0000269|PubMed 23249124}. # SUPFAM SSF52540 SSF52540 # TCDB 3.A.1.12 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR01186 proV # eggNOG COG4175 LUCA # eggNOG ENOG4108IJ7 Bacteria BLAST swissprot:PROV_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PROV_ECOLI BioCyc ECOL316407:JW2652-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2652-MONOMER BioCyc EcoCyc:PROV-MONOMER http://biocyc.org/getid?id=EcoCyc:PROV-MONOMER BioCyc MetaCyc:PROV-MONOMER http://biocyc.org/getid?id=MetaCyc:PROV-MONOMER COG COG4175 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4175 DIP DIP-10574N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10574N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1007/BF00290728 http://dx.doi.org/10.1007/BF00290728 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1365-2958.1989.tb00253.x http://dx.doi.org/10.1111/j.1365-2958.1989.tb00253.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.3109/09687688.2012.754060 http://dx.doi.org/10.3109/09687688.2012.754060 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M24856 http://www.ebi.ac.uk/ena/data/view/M24856 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X52694 http://www.ebi.ac.uk/ena/data/view/X52694 EchoBASE EB0764 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0764 EcoGene EG10771 http://www.ecogene.org/geneInfo.php?eg_id=EG10771 EnsemblBacteria AAC75724 http://www.ensemblgenomes.org/id/AAC75724 EnsemblBacteria AAC75724 http://www.ensemblgenomes.org/id/AAC75724 EnsemblBacteria BAA16542 http://www.ensemblgenomes.org/id/BAA16542 EnsemblBacteria BAA16542 http://www.ensemblgenomes.org/id/BAA16542 EnsemblBacteria BAA16542 http://www.ensemblgenomes.org/id/BAA16542 EnsemblBacteria b2677 http://www.ensemblgenomes.org/id/b2677 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0015171 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_process GO:0031460 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031460 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947148 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947148 InParanoid P14175 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P14175 IntAct P14175 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P14175* InterPro IPR000644 http://www.ebi.ac.uk/interpro/entry/IPR000644 InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR005892 http://www.ebi.ac.uk/interpro/entry/IPR005892 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2652 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2652 KEGG_Gene eco:b2677 http://www.genome.jp/dbget-bin/www_bget?eco:b2677 KEGG_Orthology KO:K02000 http://www.genome.jp/dbget-bin/www_bget?KO:K02000 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 MINT MINT-1249790 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1249790 OMA PLIRLEM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PLIRLEM PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PROSITE PS51371 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51371 PSORT swissprot:PROV_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PROV_ECOLI PSORT-B swissprot:PROV_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PROV_ECOLI PSORT2 swissprot:PROV_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PROV_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Pfam PF00571 http://pfam.xfam.org/family/PF00571 Phobius swissprot:PROV_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PROV_ECOLI PhylomeDB P14175 http://phylomedb.org/?seqid=P14175 ProteinModelPortal P14175 http://www.proteinmodelportal.org/query/uniprot/P14175 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 23249124 http://www.ncbi.nlm.nih.gov/pubmed/23249124 PubMed 2649479 http://www.ncbi.nlm.nih.gov/pubmed/2649479 PubMed 2691838 http://www.ncbi.nlm.nih.gov/pubmed/2691838 PubMed 3305496 http://www.ncbi.nlm.nih.gov/pubmed/3305496 PubMed 7898450 http://www.ncbi.nlm.nih.gov/pubmed/7898450 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417163 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417163 RefSeq WP_000985494 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000985494 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P14175 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P14175 STRING 511145.b2677 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2677&targetmode=cogs STRING COG4175 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4175&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.12 http://www.tcdb.org/search/result.php?tc=3.A.1.12 TIGRFAMs TIGR01186 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01186 UniProtKB PROV_ECOLI http://www.uniprot.org/uniprot/PROV_ECOLI UniProtKB-AC P14175 http://www.uniprot.org/uniprot/P14175 charge swissprot:PROV_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PROV_ECOLI eggNOG COG4175 http://eggnogapi.embl.de/nog_data/html/tree/COG4175 eggNOG ENOG4108IJ7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108IJ7 epestfind swissprot:PROV_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PROV_ECOLI garnier swissprot:PROV_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PROV_ECOLI helixturnhelix swissprot:PROV_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PROV_ECOLI hmoment swissprot:PROV_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PROV_ECOLI iep swissprot:PROV_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PROV_ECOLI inforesidue swissprot:PROV_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PROV_ECOLI octanol swissprot:PROV_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PROV_ECOLI pepcoil swissprot:PROV_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PROV_ECOLI pepdigest swissprot:PROV_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PROV_ECOLI pepinfo swissprot:PROV_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PROV_ECOLI pepnet swissprot:PROV_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PROV_ECOLI pepstats swissprot:PROV_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PROV_ECOLI pepwheel swissprot:PROV_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PROV_ECOLI pepwindow swissprot:PROV_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PROV_ECOLI sigcleave swissprot:PROV_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PROV_ECOLI ## Database ID URL or Descriptions # AltName LDHD_ECOLI Fermentative lactate dehydrogenase # BioGrid 4259502 6 # CATALYTIC ACTIVITY LDHD_ECOLI (R)-lactate + NAD(+) = pyruvate + NADH. # EcoGene EG13186 ldhA # FUNCTION LDHD_ECOLI Fermentative lactate dehydrogenase. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008720 D-lactate dehydrogenase activity; IDA:EcoCyc. # GO_function GO:0070404 NADH binding; IDA:EcoliWiki. # GO_process GO:0009408 response to heat; IEP:EcoliWiki. # GO_process GO:0019664 mixed acid fermentation; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0006950 response to stress # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.720 -; 2. # IntAct P52643 3 # InterPro IPR006139 D-isomer_2_OHA_DH_cat_dom # InterPro IPR006140 D-isomer_DH_NAD-bd # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR029752 D-isomer_DH_CS1 # InterPro IPR029753 D-isomer_DH_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00620 Pyruvate metabolism # Organism LDHD_ECOLI Escherichia coli (strain K12) # PATRIC 32118046 VBIEscCol129921_1443 # PIR G64888 G64888 # PROSITE PS00065 D_2_HYDROXYACID_DH_1 # PROSITE PS00670 D_2_HYDROXYACID_DH_2 # PROSITE PS00671 D_2_HYDROXYACID_DH_3 # Pfam PF00389 2-Hacid_dh # Pfam PF02826 2-Hacid_dh_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LDHD_ECOLI D-lactate dehydrogenase # RefSeq NP_415898 NC_000913.3 # RefSeq WP_000762236 NZ_LN832404.1 # SIMILARITY Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. {ECO 0000305}. # SUPFAM SSF51735 SSF51735 # eggNOG COG1052 LUCA # eggNOG ENOG4105C5I Bacteria BLAST swissprot:LDHD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LDHD_ECOLI BioCyc ECOL316407:JW1375-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1375-MONOMER BioCyc EcoCyc:DLACTDEHYDROGNAD-MONOMER http://biocyc.org/getid?id=EcoCyc:DLACTDEHYDROGNAD-MONOMER BioCyc MetaCyc:DLACTDEHYDROGNAD-MONOMER http://biocyc.org/getid?id=MetaCyc:DLACTDEHYDROGNAD-MONOMER COG COG1052 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1052 DIP DIP-10087N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10087N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1099/00221287-143-1-187 http://dx.doi.org/10.1099/00221287-143-1-187 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.28 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.28 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36928 http://www.ebi.ac.uk/ena/data/view/U36928 ENZYME 1.1.1.28 http://enzyme.expasy.org/EC/1.1.1.28 EchoBASE EB2978 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2978 EcoGene EG13186 http://www.ecogene.org/geneInfo.php?eg_id=EG13186 EnsemblBacteria AAC74462 http://www.ensemblgenomes.org/id/AAC74462 EnsemblBacteria AAC74462 http://www.ensemblgenomes.org/id/AAC74462 EnsemblBacteria BAA14990 http://www.ensemblgenomes.org/id/BAA14990 EnsemblBacteria BAA14990 http://www.ensemblgenomes.org/id/BAA14990 EnsemblBacteria BAA14990 http://www.ensemblgenomes.org/id/BAA14990 EnsemblBacteria b1380 http://www.ensemblgenomes.org/id/b1380 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008720 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008720 GO_function GO:0070404 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070404 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GO_process GO:0019664 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019664 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 946315 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946315 HOGENOM HOG000136695 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000136695&db=HOGENOM6 InParanoid P52643 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P52643 IntAct P52643 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P52643* IntEnz 1.1.1.28 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.28 InterPro IPR006139 http://www.ebi.ac.uk/interpro/entry/IPR006139 InterPro IPR006140 http://www.ebi.ac.uk/interpro/entry/IPR006140 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR029752 http://www.ebi.ac.uk/interpro/entry/IPR029752 InterPro IPR029753 http://www.ebi.ac.uk/interpro/entry/IPR029753 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1375 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1375 KEGG_Gene eco:b1380 http://www.genome.jp/dbget-bin/www_bget?eco:b1380 KEGG_Orthology KO:K03778 http://www.genome.jp/dbget-bin/www_bget?KO:K03778 KEGG_Pathway ko00620 http://www.genome.jp/kegg-bin/show_pathway?ko00620 KEGG_Reaction rn:R00704 http://www.genome.jp/dbget-bin/www_bget?rn:R00704 OMA VIVTAHQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VIVTAHQ PROSITE PS00065 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00065 PROSITE PS00670 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00670 PROSITE PS00671 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00671 PSORT swissprot:LDHD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LDHD_ECOLI PSORT-B swissprot:LDHD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LDHD_ECOLI PSORT2 swissprot:LDHD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LDHD_ECOLI Pfam PF00389 http://pfam.xfam.org/family/PF00389 Pfam PF02826 http://pfam.xfam.org/family/PF02826 Phobius swissprot:LDHD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LDHD_ECOLI PhylomeDB P52643 http://phylomedb.org/?seqid=P52643 ProteinModelPortal P52643 http://www.proteinmodelportal.org/query/uniprot/P52643 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8349564 http://www.ncbi.nlm.nih.gov/pubmed/8349564 PubMed 9025293 http://www.ncbi.nlm.nih.gov/pubmed/9025293 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_415898 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415898 RefSeq WP_000762236 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000762236 SMR P52643 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P52643 STRING 511145.b1380 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1380&targetmode=cogs STRING COG1052 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1052&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB LDHD_ECOLI http://www.uniprot.org/uniprot/LDHD_ECOLI UniProtKB-AC P52643 http://www.uniprot.org/uniprot/P52643 charge swissprot:LDHD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LDHD_ECOLI eggNOG COG1052 http://eggnogapi.embl.de/nog_data/html/tree/COG1052 eggNOG ENOG4105C5I http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C5I epestfind swissprot:LDHD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LDHD_ECOLI garnier swissprot:LDHD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LDHD_ECOLI helixturnhelix swissprot:LDHD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LDHD_ECOLI hmoment swissprot:LDHD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LDHD_ECOLI iep swissprot:LDHD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LDHD_ECOLI inforesidue swissprot:LDHD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LDHD_ECOLI octanol swissprot:LDHD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LDHD_ECOLI pepcoil swissprot:LDHD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LDHD_ECOLI pepdigest swissprot:LDHD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LDHD_ECOLI pepinfo swissprot:LDHD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LDHD_ECOLI pepnet swissprot:LDHD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LDHD_ECOLI pepstats swissprot:LDHD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LDHD_ECOLI pepwheel swissprot:LDHD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LDHD_ECOLI pepwindow swissprot:LDHD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LDHD_ECOLI sigcleave swissprot:LDHD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LDHD_ECOLI ## Database ID URL or Descriptions # BioGrid 4260602 6 # DISRUPTION PHENOTYPE RSEB_ECOLI About 2-fold increased sigma-E activity, 2- fold decrease in stability of RseA. {ECO 0000269|PubMed 10500101, ECO 0000269|PubMed 9159522, ECO 0000269|PubMed 9159523}. # DOMAIN RSEB_ECOLI The N-terminal domain (residues 24-203) is responsible for oligomerization, while the C-terminal domain (residues 222-318) interacts with RseA. {ECO 0000269|PubMed 17692869}. # ENZYME REGULATION Binding to RseA is inhibited by LPS fragments; phosphorylated N-acetylglucosamine (GlcNAc) with N-linked acyl chains are minimally necessary to disrupt binding to RseA. Once RseB is no longer bound to RseA the latter is susceptible to DegS degradation. Thus if periplasmic LPS levels increase the sigma-E regulon is induced. {ECO:0000269|PubMed 23687042}. # EcoGene EG13177 rseB # FUNCTION RSEB_ECOLI Negatively modulates the activity of sigma-E (RpoE) by stabilizing RseA under non-stress conditions. Although not essential for association of sigma-E with Rsea it increases their affinity 2- to 3-fold. When bound to RseA it prevents proteolysis by DegS, which is probably relieved by lipopolysaccharide binding (LPS). {ECO 0000269|PubMed 10500101, ECO 0000269|PubMed 17360428, ECO 0000269|PubMed 21245315, ECO 0000269|PubMed 23687042, ECO 0000269|PubMed 9159522, ECO 0000269|PubMed 9159523}. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0008289 lipid binding; IEA:UniProtKB-KW. # GO_function GO:0016989 sigma factor antagonist activity; IMP:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0000988 transcription factor activity, protein binding # GOslim_function GO:0008289 lipid binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # INTERACTION RSEB_ECOLI P0AFX7 rseA; NbExp=6; IntAct=EBI-1135231, EBI-1117560; # IntAct P0AFX9 2 # InterPro IPR005588 MucB_RseB # InterPro IPR033434 MucB/RseB_N # InterPro IPR033436 MucB/RseB_C # MISCELLANEOUS RSEB_ECOLI Part of the rpoE-rseA-rseB-rseC operon. # Organism RSEB_ECOLI Escherichia coli (strain K12) # PATRIC 32120541 VBIEscCol129921_2673 # PDB 2P4B X-ray; 2.40 A; A/B/C=24-318 # PDB 2V42 X-ray; 2.75 A; A/B=23-318 # PDB 2V43 X-ray; 2.37 A; A/B/C=23-318 # PDB 3M4W X-ray; 2.30 A; A/B/C/D=24-318 # PIR I83298 I83298 # PIRSF PIRSF005427 RseB # Pfam PF03888 MucB_RseB # Pfam PF17188 MucB_RseB_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RSEB_ECOLI Sigma-E factor regulatory protein RseB # RefSeq NP_417066 NC_000913.3 # RefSeq WP_000812053 NZ_LN832404.1 # SIMILARITY Belongs to the RseB family. {ECO 0000305}. # SUBCELLULAR LOCATION RSEB_ECOLI Periplasm {ECO 0000269|PubMed 11777003, ECO 0000269|PubMed 9159522, ECO 0000269|PubMed 9159523}. Note=Partially associates with the inner membrane via RseA. # SUBUNIT RSEB_ECOLI Homodimer. Interacts with RseA with 1 1 stoichiometry. Binding to LPS stabilzes a homotetramer that does not bind RseA. {ECO 0000269|PubMed 11777003, ECO 0000269|PubMed 17360428, ECO 0000269|PubMed 17496148, ECO 0000269|PubMed 17692869, ECO 0000269|PubMed 18421143, ECO 0000269|PubMed 20512978, ECO 0000269|PubMed 9159522, ECO 0000269|PubMed 9159523}. # eggNOG COG3026 LUCA # eggNOG ENOG4105VQK Bacteria BLAST swissprot:RSEB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RSEB_ECOLI BioCyc ECOL316407:JW2555-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2555-MONOMER BioCyc EcoCyc:G7348-MONOMER http://biocyc.org/getid?id=EcoCyc:G7348-MONOMER COG COG3026 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3026 DIP DIP-10802N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10802N DOI 10.1002/pro.393 http://dx.doi.org/10.1002/pro.393 DOI 10.1016/j.jmb.2007.06.039 http://dx.doi.org/10.1016/j.jmb.2007.06.039 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1997.3601713.x http://dx.doi.org/10.1046/j.1365-2958.1997.3601713.x DOI 10.1046/j.1365-2958.1997.3611718.x http://dx.doi.org/10.1046/j.1365-2958.1997.3611718.x DOI 10.1073/pnas.0611567104 http://dx.doi.org/10.1073/pnas.0611567104 DOI 10.1073/pnas.0703117104 http://dx.doi.org/10.1073/pnas.0703117104 DOI 10.1073/pnas.1019277108 http://dx.doi.org/10.1073/pnas.1019277108 DOI 10.1074/jbc.M006214200 http://dx.doi.org/10.1074/jbc.M006214200 DOI 10.1101/gad.13.18.2449 http://dx.doi.org/10.1101/gad.13.18.2449 DOI 10.1107/S0909049507066319 http://dx.doi.org/10.1107/S0909049507066319 DOI 10.1126/science.1235358 http://dx.doi.org/10.1126/science.1235358 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D64044 http://www.ebi.ac.uk/ena/data/view/D64044 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U37089 http://www.ebi.ac.uk/ena/data/view/U37089 EMBL U37455 http://www.ebi.ac.uk/ena/data/view/U37455 EchoBASE EB2969 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2969 EcoGene EG13177 http://www.ecogene.org/geneInfo.php?eg_id=EG13177 EnsemblBacteria AAC75624 http://www.ensemblgenomes.org/id/AAC75624 EnsemblBacteria AAC75624 http://www.ensemblgenomes.org/id/AAC75624 EnsemblBacteria BAE76747 http://www.ensemblgenomes.org/id/BAE76747 EnsemblBacteria BAE76747 http://www.ensemblgenomes.org/id/BAE76747 EnsemblBacteria BAE76747 http://www.ensemblgenomes.org/id/BAE76747 EnsemblBacteria b2571 http://www.ensemblgenomes.org/id/b2571 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0008289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289 GO_function GO:0016989 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016989 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0000988 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000988 GOslim_function GO:0008289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 947054 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947054 HOGENOM HOG000272273 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000272273&db=HOGENOM6 InParanoid P0AFX9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFX9 IntAct P0AFX9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFX9* InterPro IPR005588 http://www.ebi.ac.uk/interpro/entry/IPR005588 InterPro IPR033434 http://www.ebi.ac.uk/interpro/entry/IPR033434 InterPro IPR033436 http://www.ebi.ac.uk/interpro/entry/IPR033436 KEGG_Gene ecj:JW2555 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2555 KEGG_Gene eco:b2571 http://www.genome.jp/dbget-bin/www_bget?eco:b2571 KEGG_Orthology KO:K03598 http://www.genome.jp/dbget-bin/www_bget?KO:K03598 OMA DDFRYQY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DDFRYQY PDB 2P4B http://www.ebi.ac.uk/pdbe-srv/view/entry/2P4B PDB 2V42 http://www.ebi.ac.uk/pdbe-srv/view/entry/2V42 PDB 2V43 http://www.ebi.ac.uk/pdbe-srv/view/entry/2V43 PDB 3M4W http://www.ebi.ac.uk/pdbe-srv/view/entry/3M4W PDBsum 2P4B http://www.ebi.ac.uk/pdbsum/2P4B PDBsum 2V42 http://www.ebi.ac.uk/pdbsum/2V42 PDBsum 2V43 http://www.ebi.ac.uk/pdbsum/2V43 PDBsum 3M4W http://www.ebi.ac.uk/pdbsum/3M4W PSORT swissprot:RSEB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RSEB_ECOLI PSORT-B swissprot:RSEB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RSEB_ECOLI PSORT2 swissprot:RSEB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RSEB_ECOLI Pfam PF03888 http://pfam.xfam.org/family/PF03888 Pfam PF17188 http://pfam.xfam.org/family/PF17188 Phobius swissprot:RSEB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RSEB_ECOLI ProteinModelPortal P0AFX9 http://www.proteinmodelportal.org/query/uniprot/P0AFX9 PubMed 10500101 http://www.ncbi.nlm.nih.gov/pubmed/10500101 PubMed 11777003 http://www.ncbi.nlm.nih.gov/pubmed/11777003 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17360428 http://www.ncbi.nlm.nih.gov/pubmed/17360428 PubMed 17496148 http://www.ncbi.nlm.nih.gov/pubmed/17496148 PubMed 17692869 http://www.ncbi.nlm.nih.gov/pubmed/17692869 PubMed 18421143 http://www.ncbi.nlm.nih.gov/pubmed/18421143 PubMed 20512978 http://www.ncbi.nlm.nih.gov/pubmed/20512978 PubMed 21245315 http://www.ncbi.nlm.nih.gov/pubmed/21245315 PubMed 23687042 http://www.ncbi.nlm.nih.gov/pubmed/23687042 PubMed 7889935 http://www.ncbi.nlm.nih.gov/pubmed/7889935 PubMed 9159522 http://www.ncbi.nlm.nih.gov/pubmed/9159522 PubMed 9159523 http://www.ncbi.nlm.nih.gov/pubmed/9159523 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417066 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417066 RefSeq WP_000812053 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000812053 SMR P0AFX9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFX9 STRING 511145.b2571 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2571&targetmode=cogs STRING COG3026 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3026&targetmode=cogs UniProtKB RSEB_ECOLI http://www.uniprot.org/uniprot/RSEB_ECOLI UniProtKB-AC P0AFX9 http://www.uniprot.org/uniprot/P0AFX9 charge swissprot:RSEB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RSEB_ECOLI eggNOG COG3026 http://eggnogapi.embl.de/nog_data/html/tree/COG3026 eggNOG ENOG4105VQK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VQK epestfind swissprot:RSEB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RSEB_ECOLI garnier swissprot:RSEB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RSEB_ECOLI helixturnhelix swissprot:RSEB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RSEB_ECOLI hmoment swissprot:RSEB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RSEB_ECOLI iep swissprot:RSEB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RSEB_ECOLI inforesidue swissprot:RSEB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RSEB_ECOLI octanol swissprot:RSEB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RSEB_ECOLI pepcoil swissprot:RSEB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RSEB_ECOLI pepdigest swissprot:RSEB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RSEB_ECOLI pepinfo swissprot:RSEB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RSEB_ECOLI pepnet swissprot:RSEB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RSEB_ECOLI pepstats swissprot:RSEB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RSEB_ECOLI pepwheel swissprot:RSEB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RSEB_ECOLI pepwindow swissprot:RSEB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RSEB_ECOLI sigcleave swissprot:RSEB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RSEB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260262 20 # EcoGene EG13953 ydhS # GO_function GO:0016491 oxidoreductase activity; IEA:InterPro. # GOslim_function GO:0016491 oxidoreductase activity # Gene3D 3.40.50.720 -; 2. # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR023753 FAD/NAD-binding_dom # Organism YDHS_ECOLI Escherichia coli (strain K12) # PATRIC 32118642 VBIEscCol129921_1739 # PIR D64924 D64924 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDHS_ECOLI Uncharacterized protein YdhS # RefSeq NP_416183 NC_000913.3 # RefSeq WP_000716950 NZ_LN832404.1 # SUPFAM SSF51905 SSF51905 # eggNOG COG4529 LUCA # eggNOG ENOG4108KTU Bacteria BLAST swissprot:YDHS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDHS_ECOLI BioCyc ECOL316407:JW1658-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1658-MONOMER BioCyc EcoCyc:G6896-MONOMER http://biocyc.org/getid?id=EcoCyc:G6896-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U68703 http://www.ebi.ac.uk/ena/data/view/U68703 EchoBASE EB3711 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3711 EcoGene EG13953 http://www.ecogene.org/geneInfo.php?eg_id=EG13953 EnsemblBacteria AAC74738 http://www.ensemblgenomes.org/id/AAC74738 EnsemblBacteria AAC74738 http://www.ensemblgenomes.org/id/AAC74738 EnsemblBacteria BAE76496 http://www.ensemblgenomes.org/id/BAE76496 EnsemblBacteria BAE76496 http://www.ensemblgenomes.org/id/BAE76496 EnsemblBacteria BAE76496 http://www.ensemblgenomes.org/id/BAE76496 EnsemblBacteria b1668 http://www.ensemblgenomes.org/id/b1668 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 945786 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945786 HOGENOM HOG000120919 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120919&db=HOGENOM6 IntAct P77148 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77148* InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 KEGG_Gene ecj:JW1658 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1658 KEGG_Gene eco:b1668 http://www.genome.jp/dbget-bin/www_bget?eco:b1668 OMA PTGIYTF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PTGIYTF PSORT swissprot:YDHS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDHS_ECOLI PSORT-B swissprot:YDHS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDHS_ECOLI PSORT2 swissprot:YDHS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDHS_ECOLI Phobius swissprot:YDHS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDHS_ECOLI ProteinModelPortal P77148 http://www.proteinmodelportal.org/query/uniprot/P77148 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9023191 http://www.ncbi.nlm.nih.gov/pubmed/9023191 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416183 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416183 RefSeq WP_000716950 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000716950 STRING 511145.b1668 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1668&targetmode=cogs SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 UniProtKB YDHS_ECOLI http://www.uniprot.org/uniprot/YDHS_ECOLI UniProtKB-AC P77148 http://www.uniprot.org/uniprot/P77148 charge swissprot:YDHS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDHS_ECOLI eggNOG COG4529 http://eggnogapi.embl.de/nog_data/html/tree/COG4529 eggNOG ENOG4108KTU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108KTU epestfind swissprot:YDHS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDHS_ECOLI garnier swissprot:YDHS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDHS_ECOLI helixturnhelix swissprot:YDHS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDHS_ECOLI hmoment swissprot:YDHS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDHS_ECOLI iep swissprot:YDHS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDHS_ECOLI inforesidue swissprot:YDHS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDHS_ECOLI octanol swissprot:YDHS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDHS_ECOLI pepcoil swissprot:YDHS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDHS_ECOLI pepdigest swissprot:YDHS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDHS_ECOLI pepinfo swissprot:YDHS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDHS_ECOLI pepnet swissprot:YDHS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDHS_ECOLI pepstats swissprot:YDHS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDHS_ECOLI pepwheel swissprot:YDHS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDHS_ECOLI pepwindow swissprot:YDHS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDHS_ECOLI sigcleave swissprot:YDHS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDHS_ECOLI ## Database ID URL or Descriptions # BioGrid 4263200 3 # CDD cd01399 GlcN6P_deaminase # EcoGene EG11728 yieK # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0004342 glucosamine-6-phosphate deaminase activity; IBA:GO_Central. # GO_process GO:0005975 carbohydrate metabolic process; IEA:InterPro. # GO_process GO:0006046 N-acetylglucosamine catabolic process; IBA:GO_Central. # GO_process GO:0006048 UDP-N-acetylglucosamine biosynthetic process; IBA:GO_Central. # GO_process GO:0019262 N-acetylneuraminate catabolic process; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # InterPro IPR004547 Glucosamine6P_isomerase # InterPro IPR006148 Glc/Gal-6P_isomerase # InterPro IPR018321 Glucosamine6P_isomerase_CS # Organism YIEK_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11280 PTHR11280 # PATRIC 32122931 VBIEscCol129921_3841 # PROSITE PS01161 GLC_GALNAC_ISOMERASE # Pfam PF01182 Glucosamine_iso # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIEK_ECOLI Uncharacterized protein YieK # RefSeq WP_000766900 NZ_LN832404.1 # RefSeq YP_026242 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA62069.1; Type=Frameshift; Positions=17; Evidence={ECO 0000305}; # SIMILARITY Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. {ECO 0000305}. # eggNOG COG0363 LUCA # eggNOG ENOG4107VKM Bacteria BLAST swissprot:YIEK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIEK_ECOLI BioCyc ECOL316407:JW5613-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5613-MONOMER BioCyc EcoCyc:EG11728-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11728-MONOMER DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1679 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1679 EcoGene EG11728 http://www.ecogene.org/geneInfo.php?eg_id=EG11728 EnsemblBacteria AAT48202 http://www.ensemblgenomes.org/id/AAT48202 EnsemblBacteria AAT48202 http://www.ensemblgenomes.org/id/AAT48202 EnsemblBacteria BAE77570 http://www.ensemblgenomes.org/id/BAE77570 EnsemblBacteria BAE77570 http://www.ensemblgenomes.org/id/BAE77570 EnsemblBacteria BAE77570 http://www.ensemblgenomes.org/id/BAE77570 EnsemblBacteria b3718 http://www.ensemblgenomes.org/id/b3718 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004342 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004342 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GO_process GO:0006046 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006046 GO_process GO:0006048 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006048 GO_process GO:0019262 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019262 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 948229 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948229 HOGENOM HOG000064978 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000064978&db=HOGENOM6 InParanoid P31470 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31470 InterPro IPR004547 http://www.ebi.ac.uk/interpro/entry/IPR004547 InterPro IPR006148 http://www.ebi.ac.uk/interpro/entry/IPR006148 InterPro IPR018321 http://www.ebi.ac.uk/interpro/entry/IPR018321 KEGG_Gene ecj:JW5613 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5613 KEGG_Gene eco:b3718 http://www.genome.jp/dbget-bin/www_bget?eco:b3718 OMA NNQVFDQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NNQVFDQ PANTHER PTHR11280 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11280 PROSITE PS01161 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01161 PSORT swissprot:YIEK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIEK_ECOLI PSORT-B swissprot:YIEK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIEK_ECOLI PSORT2 swissprot:YIEK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIEK_ECOLI Pfam PF01182 http://pfam.xfam.org/family/PF01182 Phobius swissprot:YIEK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIEK_ECOLI PhylomeDB P31470 http://phylomedb.org/?seqid=P31470 ProteinModelPortal P31470 http://www.proteinmodelportal.org/query/uniprot/P31470 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000766900 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000766900 RefSeq YP_026242 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026242 SMR P31470 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31470 STRING 511145.b3718 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3718&targetmode=cogs UniProtKB YIEK_ECOLI http://www.uniprot.org/uniprot/YIEK_ECOLI UniProtKB-AC P31470 http://www.uniprot.org/uniprot/P31470 charge swissprot:YIEK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIEK_ECOLI eggNOG COG0363 http://eggnogapi.embl.de/nog_data/html/tree/COG0363 eggNOG ENOG4107VKM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107VKM epestfind swissprot:YIEK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIEK_ECOLI garnier swissprot:YIEK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIEK_ECOLI helixturnhelix swissprot:YIEK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIEK_ECOLI hmoment swissprot:YIEK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIEK_ECOLI iep swissprot:YIEK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIEK_ECOLI inforesidue swissprot:YIEK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIEK_ECOLI octanol swissprot:YIEK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIEK_ECOLI pepcoil swissprot:YIEK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIEK_ECOLI pepdigest swissprot:YIEK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIEK_ECOLI pepinfo swissprot:YIEK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIEK_ECOLI pepnet swissprot:YIEK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIEK_ECOLI pepstats swissprot:YIEK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIEK_ECOLI pepwheel swissprot:YIEK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIEK_ECOLI pepwindow swissprot:YIEK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIEK_ECOLI sigcleave swissprot:YIEK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIEK_ECOLI ## Database ID URL or Descriptions # BioGrid 4261391 99 # DISRUPTION PHENOTYPE Cells lacking this gene fail to grow on L- galactonate as sole carbon source. {ECO:0000269|PubMed 17088549}. # EcoGene EG12589 lgoR # FUNCTION LGOR_ECOLI May be a positive transcriptional regulator for lgoD and/or lgoT. Is essential for growth on L-galactonate as the sole carbon source. {ECO 0000269|PubMed 17088549}. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; ISS:EcoCyc. # GO_process GO:0019584 galactonate catabolic process; IMP:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.10.10 -; 2. # Gene3D 1.20.120.530 -; 1. # INDUCTION Highly up-regulated during growth on L-galactonate. {ECO:0000269|PubMed 17088549}. # InterPro IPR000524 Tscrpt_reg_HTH_GntR # InterPro IPR008920 TF_FadR/GntR_C # InterPro IPR011711 GntR_C # InterPro IPR011991 WHTH_DNA-bd_dom # Organism LGOR_ECOLI Escherichia coli (strain K12) # PATRIC 32124320 VBIEscCol129921_4503 # PIR S56584 S56584 # PRINTS PR00035 HTHGNTR # Pfam PF00392 GntR # Pfam PF07729 FCD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LGOR_ECOLI Probable HTH-type transcriptional regulator LgoR # RefSeq WP_000091570 NZ_LN832404.1 # RefSeq YP_026290 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA97255.1; Type=Frameshift; Positions=29; Evidence={ECO 0000305}; # SIMILARITY Contains 1 HTH gntR-type DNA-binding domain. {ECO 0000305}. # SMART SM00895 FCD # SUPFAM SSF46785 SSF46785; 2 # SUPFAM SSF48008 SSF48008 # eggNOG COG1802 LUCA # eggNOG ENOG410617M Bacteria BLAST swissprot:LGOR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LGOR_ECOLI BioCyc ECOL316407:JW5792-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5792-MONOMER BioCyc EcoCyc:G7944-MONOMER http://biocyc.org/getid?id=EcoCyc:G7944-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0603364103 http://dx.doi.org/10.1073/pnas.0603364103 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2474 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2474 EcoGene EG12589 http://www.ecogene.org/geneInfo.php?eg_id=EG12589 EnsemblBacteria AAT48248 http://www.ensemblgenomes.org/id/AAT48248 EnsemblBacteria AAT48248 http://www.ensemblgenomes.org/id/AAT48248 EnsemblBacteria BAE78347 http://www.ensemblgenomes.org/id/BAE78347 EnsemblBacteria BAE78347 http://www.ensemblgenomes.org/id/BAE78347 EnsemblBacteria BAE78347 http://www.ensemblgenomes.org/id/BAE78347 EnsemblBacteria b4357 http://www.ensemblgenomes.org/id/b4357 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0019584 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019584 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 1.20.120.530 http://www.cathdb.info/version/latest/superfamily/1.20.120.530 GeneID 948881 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948881 HOGENOM HOG000127562 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000127562&db=HOGENOM6 InterPro IPR000524 http://www.ebi.ac.uk/interpro/entry/IPR000524 InterPro IPR008920 http://www.ebi.ac.uk/interpro/entry/IPR008920 InterPro IPR011711 http://www.ebi.ac.uk/interpro/entry/IPR011711 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW5792 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5792 KEGG_Gene eco:b4357 http://www.genome.jp/dbget-bin/www_bget?eco:b4357 OMA REMFELH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=REMFELH PRINTS PR00035 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00035 PSORT swissprot:LGOR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LGOR_ECOLI PSORT-B swissprot:LGOR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LGOR_ECOLI PSORT2 swissprot:LGOR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LGOR_ECOLI Pfam PF00392 http://pfam.xfam.org/family/PF00392 Pfam PF07729 http://pfam.xfam.org/family/PF07729 Phobius swissprot:LGOR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LGOR_ECOLI PhylomeDB P39399 http://phylomedb.org/?seqid=P39399 ProteinModelPortal P39399 http://www.proteinmodelportal.org/query/uniprot/P39399 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17088549 http://www.ncbi.nlm.nih.gov/pubmed/17088549 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000091570 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000091570 RefSeq YP_026290 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026290 SMART SM00895 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00895 SMR P39399 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39399 STRING 511145.b4357 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4357&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SUPFAM SSF48008 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48008 UniProtKB LGOR_ECOLI http://www.uniprot.org/uniprot/LGOR_ECOLI UniProtKB-AC P39399 http://www.uniprot.org/uniprot/P39399 charge swissprot:LGOR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LGOR_ECOLI eggNOG COG1802 http://eggnogapi.embl.de/nog_data/html/tree/COG1802 eggNOG ENOG410617M http://eggnogapi.embl.de/nog_data/html/tree/ENOG410617M epestfind swissprot:LGOR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LGOR_ECOLI garnier swissprot:LGOR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LGOR_ECOLI helixturnhelix swissprot:LGOR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LGOR_ECOLI hmoment swissprot:LGOR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LGOR_ECOLI iep swissprot:LGOR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LGOR_ECOLI inforesidue swissprot:LGOR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LGOR_ECOLI octanol swissprot:LGOR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LGOR_ECOLI pepcoil swissprot:LGOR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LGOR_ECOLI pepdigest swissprot:LGOR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LGOR_ECOLI pepinfo swissprot:LGOR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LGOR_ECOLI pepnet swissprot:LGOR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LGOR_ECOLI pepstats swissprot:LGOR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LGOR_ECOLI pepwheel swissprot:LGOR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LGOR_ECOLI pepwindow swissprot:LGOR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LGOR_ECOLI sigcleave swissprot:LGOR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LGOR_ECOLI ## Database ID URL or Descriptions # AltName TNPX_ECOLI Transposon Tn1000 protein TnpX # Gene3D 3.40.50.300 -; 1. # InterPro IPR027417 P-loop_NTPase # Organism TNPX_ECOLI Escherichia coli (strain K12) # PIR I60218 I60218 # RecName TNPX_ECOLI Putative transposon gamma-delta 80.3 kDa protein # RefSeq NP_061387 NC_002483.1 # RefSeq WP_000422420 NZ_CP014273.1 # SUPFAM SSF52540 SSF52540; 2 # eggNOG ENOG4108MIB Bacteria # eggNOG ENOG410YHWN LUCA BLAST swissprot:TNPX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TNPX_ECOLI BioCyc ECOL316385:GJ8B-1332-MONOMER http://biocyc.org/getid?id=ECOL316385:GJ8B-1332-MONOMER DOI 10.1266/jjg.69.269 http://dx.doi.org/10.1266/jjg.69.269 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL D16449 http://www.ebi.ac.uk/ena/data/view/D16449 EMBL X60200 http://www.ebi.ac.uk/ena/data/view/X60200 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 1263581 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263581 HOGENOM HOG000263482 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000263482&db=HOGENOM6 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 OMA KSAICMR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KSAICMR PSORT swissprot:TNPX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TNPX_ECOLI PSORT-B swissprot:TNPX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TNPX_ECOLI PSORT2 swissprot:TNPX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TNPX_ECOLI Phobius swissprot:TNPX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TNPX_ECOLI ProteinModelPortal Q00042 http://www.proteinmodelportal.org/query/uniprot/Q00042 PubMed 7612932 http://www.ncbi.nlm.nih.gov/pubmed/7612932 PubMed 8080658 http://www.ncbi.nlm.nih.gov/pubmed/8080658 RefSeq NP_061387 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061387 RefSeq WP_000422420 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000422420 STRING 316385.ECDH10B_1362 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316385.ECDH10B_1362&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB TNPX_ECOLI http://www.uniprot.org/uniprot/TNPX_ECOLI UniProtKB-AC Q00042 http://www.uniprot.org/uniprot/Q00042 charge swissprot:TNPX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TNPX_ECOLI eggNOG ENOG4108MIB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MIB eggNOG ENOG410YHWN http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YHWN epestfind swissprot:TNPX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TNPX_ECOLI garnier swissprot:TNPX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TNPX_ECOLI helixturnhelix swissprot:TNPX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TNPX_ECOLI hmoment swissprot:TNPX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TNPX_ECOLI iep swissprot:TNPX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TNPX_ECOLI inforesidue swissprot:TNPX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TNPX_ECOLI octanol swissprot:TNPX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TNPX_ECOLI pepcoil swissprot:TNPX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TNPX_ECOLI pepdigest swissprot:TNPX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TNPX_ECOLI pepinfo swissprot:TNPX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TNPX_ECOLI pepnet swissprot:TNPX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TNPX_ECOLI pepstats swissprot:TNPX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TNPX_ECOLI pepwheel swissprot:TNPX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TNPX_ECOLI pepwindow swissprot:TNPX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TNPX_ECOLI sigcleave swissprot:TNPX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TNPX_ECOLI ## Database ID URL or Descriptions # AltName CLPX_ECOLI ATP-dependent unfoldase ClpX # BioGrid 4260735 503 # COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI 29105; Note=Binds 1 Zn(2+) ion per subunit.; # DISRUPTION PHENOTYPE CLPX_ECOLI Delayed and decreased induction of the extracytoplasmic-stress response. {ECO 0000269|PubMed 15371343, ECO 0000269|PubMed 17210793}. # EcoGene EG10159 clpX # FUNCTION CLPX_ECOLI ATP-dependent specificity component of the Clp protease. Uses cycles of ATP binding and hydrolysis to unfold proteins and translocate them to the ClpP protease. It directs the protease to specific substrates both with and without the help of adapter proteins such as SspB. Participates in the final steps of RseA- sigma-E degradation, liberating sigma-E to induce the extracytoplasmic-stress response. It may bind to the lambda O substrate protein and present it to the ClpP protease in a form that can be recognized and readily hydrolyzed by ClpP. Can perform chaperone functions in the absence of ClpP. {ECO 0000269|PubMed 12941278, ECO 0000269|PubMed 15371343}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004176 ATP-dependent peptidase activity; IDA:CACAO. # GO_function GO:0005524 ATP binding; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IEA:InterPro. # GO_function GO:0016887 ATPase activity; IDA:CACAO. # GO_function GO:0042802 identical protein binding; IPI:IntAct. # GO_process GO:0006457 protein folding; IEA:UniProtKB-HAMAP. # GO_process GO:0016032 viral process; IEA:UniProtKB-KW. # GO_process GO:0030163 protein catabolic process; IBA:GO_Central. # GO_process GO:0043335 protein unfolding; IDA:CACAO. # GO_process GO:0051301 cell division; IGI:CACAO. # GO_process GO:0051704 multi-organism process; IMP:UniProtKB. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006457 protein folding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044403 symbiosis, encompassing mutualism through parasitism # GOslim_process GO:0051301 cell division # Gene3D 3.40.50.300 -; 2. # HAMAP MF_00175 ClpX # INDUCTION By heat shock. Part of the clpP-clpX operon, clpX can be expressed individually from its own promoter. {ECO:0000269|PubMed 8093059}. # INTERACTION CLPX_ECOLI Self; NbExp=6; IntAct=EBI-547386, EBI-547386; # IntAct P0A6H1 32 # InterPro IPR003593 AAA+_ATPase # InterPro IPR003959 ATPase_AAA_core # InterPro IPR004487 Clp_protease_ATP-bd_su_ClpX # InterPro IPR010603 Znf_CppX_C4 # InterPro IPR019489 Clp_ATPase_C # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko03110 Chaperones and folding catalysts # KEGG_Pathway ko04112 Cell cycle - Caulobacter # Organism CLPX_ECOLI Escherichia coli (strain K12) # PATRIC 32116029 VBIEscCol129921_0456 # PDB 1OVX NMR; -; A/B=2-61 # PDB 2DS5 X-ray; 1.50 A; A/B=2-52 # PDB 2DS6 X-ray; 2.00 A; A/B=2-52 # PDB 2DS7 X-ray; 2.50 A; A=2-52 # PDB 2DS8 X-ray; 1.60 A; A/B=2-52 # PDB 3HTE X-ray; 4.03 A; A/B/C/D/E/F=62-424 # PDB 3HWS X-ray; 3.25 A; A/B/C/D/E/F=62-424 # PDB 4I34 X-ray; 4.12 A; A/B/C/D/E/F=62-424 # PDB 4I4L X-ray; 3.70 A; A/B/C/D/E/F=62-424 # PDB 4I5O X-ray; 4.48 A; A/B/C/D/E/F=62-424 # PDB 4I63 X-ray; 5.71 A; A/B/C/D/E/F=62-424 # PDB 4I81 X-ray; 3.82 A; A/B/C/D/E/F=62-424 # PDB 4I9K X-ray; 5.00 A; A/B=62-424 # PIR A48709 A48709 # Pfam PF06689 zf-C4_ClpX # Pfam PF07724 AAA_2 # Pfam PF10431 ClpB_D2-small # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ATP-dependent Clp protease ATP-binding subunit ClpX {ECO:0000255|HAMAP-Rule MF_00175} # RefSeq NP_414972 NC_000913.3 # RefSeq WP_000130305 NZ_LN832404.1 # SIMILARITY Belongs to the ClpX chaperone family. {ECO:0000255|HAMAP-Rule MF_00175}. # SMART SM00382 AAA # SMART SM00994 zf-C4_ClpX # SMART SM01086 ClpB_D2-small # SUBUNIT CLPX_ECOLI Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. Interacts with Mu phage DDE-recombinase A; this interaction remodels the viral transpososome for replication. {ECO 0000255|HAMAP-Rule MF_00175, ECO 0000269|PubMed 14525985, ECO 0000269|PubMed 17258768, ECO 0000269|PubMed 18406325, ECO 0000269|PubMed 19914167, ECO 0000269|PubMed 23622246}. # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR00382 clpX # eggNOG COG1219 LUCA # eggNOG ENOG4105CHN Bacteria BLAST swissprot:CLPX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CLPX_ECOLI BioCyc ECOL316407:JW0428-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0428-MONOMER BioCyc EcoCyc:EG10159-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10159-MONOMER BioCyc MetaCyc:EG10159-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10159-MONOMER COG COG1219 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1219 DIP DIP-35907N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35907N DOI 10.1006/bbrc.1994.2253 http://dx.doi.org/10.1006/bbrc.1994.2253 DOI 10.1016/S0092-8674(03)00612-3 http://dx.doi.org/10.1016/S0092-8674(03)00612-3 DOI 10.1016/j.cell.2009.09.034 http://dx.doi.org/10.1016/j.cell.2009.09.034 DOI 10.1016/j.cell.2013.03.029 http://dx.doi.org/10.1016/j.cell.2013.03.029 DOI 10.1016/j.jmb.2007.01.003 http://dx.doi.org/10.1016/j.jmb.2007.01.003 DOI 10.1016/j.molcel.2008.02.013 http://dx.doi.org/10.1016/j.molcel.2008.02.013 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M307826200 http://dx.doi.org/10.1074/jbc.M307826200 DOI 10.1101/gad.1240104 http://dx.doi.org/10.1101/gad.1240104 DOI 10.1101/gad.1496707 http://dx.doi.org/10.1101/gad.1496707 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L18867 http://www.ebi.ac.uk/ena/data/view/L18867 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL Z23278 http://www.ebi.ac.uk/ena/data/view/Z23278 EchoBASE EB0157 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0157 EcoGene EG10159 http://www.ecogene.org/geneInfo.php?eg_id=EG10159 EnsemblBacteria AAC73541 http://www.ensemblgenomes.org/id/AAC73541 EnsemblBacteria AAC73541 http://www.ensemblgenomes.org/id/AAC73541 EnsemblBacteria BAE76218 http://www.ensemblgenomes.org/id/BAE76218 EnsemblBacteria BAE76218 http://www.ensemblgenomes.org/id/BAE76218 EnsemblBacteria BAE76218 http://www.ensemblgenomes.org/id/BAE76218 EnsemblBacteria b0438 http://www.ensemblgenomes.org/id/b0438 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004176 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004176 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GO_process GO:0016032 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016032 GO_process GO:0030163 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030163 GO_process GO:0043335 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043335 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GO_process GO:0051704 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051704 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945083 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945083 HAMAP MF_00175 http://hamap.expasy.org/unirule/MF_00175 HOGENOM HOG000010093 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000010093&db=HOGENOM6 InParanoid P0A6H1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6H1 IntAct P0A6H1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6H1* InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR003959 http://www.ebi.ac.uk/interpro/entry/IPR003959 InterPro IPR004487 http://www.ebi.ac.uk/interpro/entry/IPR004487 InterPro IPR010603 http://www.ebi.ac.uk/interpro/entry/IPR010603 InterPro IPR019489 http://www.ebi.ac.uk/interpro/entry/IPR019489 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW0428 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0428 KEGG_Gene eco:b0438 http://www.genome.jp/dbget-bin/www_bget?eco:b0438 KEGG_Orthology KO:K03544 http://www.genome.jp/dbget-bin/www_bget?KO:K03544 KEGG_Pathway ko04112 http://www.genome.jp/kegg-bin/show_pathway?ko04112 OMA HYKRVQA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HYKRVQA PDB 1OVX http://www.ebi.ac.uk/pdbe-srv/view/entry/1OVX PDB 2DS5 http://www.ebi.ac.uk/pdbe-srv/view/entry/2DS5 PDB 2DS6 http://www.ebi.ac.uk/pdbe-srv/view/entry/2DS6 PDB 2DS7 http://www.ebi.ac.uk/pdbe-srv/view/entry/2DS7 PDB 2DS8 http://www.ebi.ac.uk/pdbe-srv/view/entry/2DS8 PDB 3HTE http://www.ebi.ac.uk/pdbe-srv/view/entry/3HTE PDB 3HWS http://www.ebi.ac.uk/pdbe-srv/view/entry/3HWS PDB 4I34 http://www.ebi.ac.uk/pdbe-srv/view/entry/4I34 PDB 4I4L http://www.ebi.ac.uk/pdbe-srv/view/entry/4I4L PDB 4I5O http://www.ebi.ac.uk/pdbe-srv/view/entry/4I5O PDB 4I63 http://www.ebi.ac.uk/pdbe-srv/view/entry/4I63 PDB 4I81 http://www.ebi.ac.uk/pdbe-srv/view/entry/4I81 PDB 4I9K http://www.ebi.ac.uk/pdbe-srv/view/entry/4I9K PDBsum 1OVX http://www.ebi.ac.uk/pdbsum/1OVX PDBsum 2DS5 http://www.ebi.ac.uk/pdbsum/2DS5 PDBsum 2DS6 http://www.ebi.ac.uk/pdbsum/2DS6 PDBsum 2DS7 http://www.ebi.ac.uk/pdbsum/2DS7 PDBsum 2DS8 http://www.ebi.ac.uk/pdbsum/2DS8 PDBsum 3HTE http://www.ebi.ac.uk/pdbsum/3HTE PDBsum 3HWS http://www.ebi.ac.uk/pdbsum/3HWS PDBsum 4I34 http://www.ebi.ac.uk/pdbsum/4I34 PDBsum 4I4L http://www.ebi.ac.uk/pdbsum/4I4L PDBsum 4I5O http://www.ebi.ac.uk/pdbsum/4I5O PDBsum 4I63 http://www.ebi.ac.uk/pdbsum/4I63 PDBsum 4I81 http://www.ebi.ac.uk/pdbsum/4I81 PDBsum 4I9K http://www.ebi.ac.uk/pdbsum/4I9K PSORT swissprot:CLPX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CLPX_ECOLI PSORT-B swissprot:CLPX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CLPX_ECOLI PSORT2 swissprot:CLPX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CLPX_ECOLI Pfam PF06689 http://pfam.xfam.org/family/PF06689 Pfam PF07724 http://pfam.xfam.org/family/PF07724 Pfam PF10431 http://pfam.xfam.org/family/PF10431 Phobius swissprot:CLPX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CLPX_ECOLI PhylomeDB P0A6H1 http://phylomedb.org/?seqid=P0A6H1 ProteinModelPortal P0A6H1 http://www.proteinmodelportal.org/query/uniprot/P0A6H1 PubMed 12941278 http://www.ncbi.nlm.nih.gov/pubmed/12941278 PubMed 14525985 http://www.ncbi.nlm.nih.gov/pubmed/14525985 PubMed 15371343 http://www.ncbi.nlm.nih.gov/pubmed/15371343 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17210793 http://www.ncbi.nlm.nih.gov/pubmed/17210793 PubMed 17258768 http://www.ncbi.nlm.nih.gov/pubmed/17258768 PubMed 18406325 http://www.ncbi.nlm.nih.gov/pubmed/18406325 PubMed 19914167 http://www.ncbi.nlm.nih.gov/pubmed/19914167 PubMed 23622246 http://www.ncbi.nlm.nih.gov/pubmed/23622246 PubMed 7743994 http://www.ncbi.nlm.nih.gov/pubmed/7743994 PubMed 8093059 http://www.ncbi.nlm.nih.gov/pubmed/8093059 PubMed 8226769 http://www.ncbi.nlm.nih.gov/pubmed/8226769 PubMed 8226770 http://www.ncbi.nlm.nih.gov/pubmed/8226770 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414972 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414972 RefSeq WP_000130305 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000130305 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMART SM00994 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00994 SMART SM01086 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01086 SMR P0A6H1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6H1 STRING 511145.b0438 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0438&targetmode=cogs STRING COG1219 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1219&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR00382 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00382 UniProtKB CLPX_ECOLI http://www.uniprot.org/uniprot/CLPX_ECOLI UniProtKB-AC P0A6H1 http://www.uniprot.org/uniprot/P0A6H1 charge swissprot:CLPX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CLPX_ECOLI eggNOG COG1219 http://eggnogapi.embl.de/nog_data/html/tree/COG1219 eggNOG ENOG4105CHN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CHN epestfind swissprot:CLPX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CLPX_ECOLI garnier swissprot:CLPX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CLPX_ECOLI helixturnhelix swissprot:CLPX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CLPX_ECOLI hmoment swissprot:CLPX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CLPX_ECOLI iep swissprot:CLPX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CLPX_ECOLI inforesidue swissprot:CLPX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CLPX_ECOLI octanol swissprot:CLPX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CLPX_ECOLI pepcoil swissprot:CLPX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CLPX_ECOLI pepdigest swissprot:CLPX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CLPX_ECOLI pepinfo swissprot:CLPX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CLPX_ECOLI pepnet swissprot:CLPX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CLPX_ECOLI pepstats swissprot:CLPX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CLPX_ECOLI pepwheel swissprot:CLPX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CLPX_ECOLI pepwindow swissprot:CLPX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CLPX_ECOLI sigcleave swissprot:CLPX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CLPX_ECOLI ## Database ID URL or Descriptions # BioGrid 4260189 81 # EcoGene EG13763 ydcT # FUNCTION YDCT_ECOLI Probably part of a binding-protein-dependent transport system YdcSTUV. Probably responsible for energy coupling to the transport system. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IEA:InterPro. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances; IEA:InterPro. # GO_function GO:0016887 ATPase activity; IEA:InterPro. # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.300 -; 1. # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR008995 Mo/tungstate-bd_C_term_dom # InterPro IPR013611 Transp-assoc_OB_typ2 # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00193 Putative spermidine/putrescine transport system # KEGG_Brite ko02000 Transporters # Organism YDCT_ECOLI Escherichia coli (strain K12) # PATRIC 32118172 VBIEscCol129921_1506 # PIR D64896 D64896 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # Pfam PF00005 ABC_tran # Pfam PF08402 TOBE_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDCT_ECOLI Uncharacterized ABC transporter ATP-binding protein YdcT # RefSeq NP_415958 NC_000913.3 # RefSeq WP_000220396 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA # SUPFAM SSF50331 SSF50331 # SUPFAM SSF52540 SSF52540 # TCDB 3.A.1.11 the atp-binding cassette (abc) superfamily # eggNOG COG3842 LUCA # eggNOG ENOG4105C53 Bacteria BLAST swissprot:YDCT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDCT_ECOLI BioCyc ECOL316407:JW1436-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1436-MONOMER BioCyc EcoCyc:YDCT-MONOMER http://biocyc.org/getid?id=EcoCyc:YDCT-MONOMER BioCyc MetaCyc:YDCT-MONOMER http://biocyc.org/getid?id=MetaCyc:YDCT-MONOMER COG COG3842 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3842 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3526 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3526 EcoGene EG13763 http://www.ecogene.org/geneInfo.php?eg_id=EG13763 EnsemblBacteria AAC74523 http://www.ensemblgenomes.org/id/AAC74523 EnsemblBacteria AAC74523 http://www.ensemblgenomes.org/id/AAC74523 EnsemblBacteria BAA15070 http://www.ensemblgenomes.org/id/BAA15070 EnsemblBacteria BAA15070 http://www.ensemblgenomes.org/id/BAA15070 EnsemblBacteria BAA15070 http://www.ensemblgenomes.org/id/BAA15070 EnsemblBacteria b1441 http://www.ensemblgenomes.org/id/b1441 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016820 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016820 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 946007 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946007 InParanoid P77795 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77795 InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR008995 http://www.ebi.ac.uk/interpro/entry/IPR008995 InterPro IPR013611 http://www.ebi.ac.uk/interpro/entry/IPR013611 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1436 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1436 KEGG_Gene eco:b1441 http://www.genome.jp/dbget-bin/www_bget?eco:b1441 KEGG_Orthology KO:K02052 http://www.genome.jp/dbget-bin/www_bget?KO:K02052 OMA SDRICIF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SDRICIF PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:YDCT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDCT_ECOLI PSORT-B swissprot:YDCT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDCT_ECOLI PSORT2 swissprot:YDCT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDCT_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Pfam PF08402 http://pfam.xfam.org/family/PF08402 Phobius swissprot:YDCT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDCT_ECOLI PhylomeDB P77795 http://phylomedb.org/?seqid=P77795 ProteinModelPortal P77795 http://www.proteinmodelportal.org/query/uniprot/P77795 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415958 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415958 RefSeq WP_000220396 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000220396 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P77795 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77795 STRING 511145.b1441 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1441&targetmode=cogs STRING COG3842 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3842&targetmode=cogs SUPFAM SSF50331 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50331 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.11 http://www.tcdb.org/search/result.php?tc=3.A.1.11 UniProtKB YDCT_ECOLI http://www.uniprot.org/uniprot/YDCT_ECOLI UniProtKB-AC P77795 http://www.uniprot.org/uniprot/P77795 charge swissprot:YDCT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDCT_ECOLI eggNOG COG3842 http://eggnogapi.embl.de/nog_data/html/tree/COG3842 eggNOG ENOG4105C53 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C53 epestfind swissprot:YDCT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDCT_ECOLI garnier swissprot:YDCT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDCT_ECOLI helixturnhelix swissprot:YDCT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDCT_ECOLI hmoment swissprot:YDCT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDCT_ECOLI iep swissprot:YDCT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDCT_ECOLI inforesidue swissprot:YDCT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDCT_ECOLI octanol swissprot:YDCT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDCT_ECOLI pepcoil swissprot:YDCT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDCT_ECOLI pepdigest swissprot:YDCT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDCT_ECOLI pepinfo swissprot:YDCT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDCT_ECOLI pepnet swissprot:YDCT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDCT_ECOLI pepstats swissprot:YDCT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDCT_ECOLI pepwheel swissprot:YDCT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDCT_ECOLI pepwindow swissprot:YDCT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDCT_ECOLI sigcleave swissprot:YDCT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDCT_ECOLI ## Database ID URL or Descriptions # BioGrid 4261191 13 # EcoGene EG12356 rtcR # FUNCTION RTCR_ECOLI Transcriptional repressor of the rtcAB genes. Interacts with sigma-54. {ECO 0000269|PubMed 9738023}. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; ISS:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0000160 phosphorelay signal transduction system; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_component GO:0005622 intracellular # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.50.300 -; 1. # IntAct P38035 5 # InterPro IPR002078 Sigma_54_int # InterPro IPR003593 AAA+_ATPase # InterPro IPR009715 RtcR # InterPro IPR017183 Sigma54_dep_tscrpt_act_RtcR # InterPro IPR025943 Sigma_54_int_dom_ATP-bd_2 # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko03000 Transcription factors # Organism RTCR_ECOLI Escherichia coli (strain K12) # PANTHER PTHR32071:SF14 PTHR32071:SF14 # PATRIC 32122280 VBIEscCol129921_3517 # PIR A65138 A65138 # PIRSF PIRSF037354 Txn_actvtr_RtcR # PROSITE PS00676 SIGMA54_INTERACT_2 # PROSITE PS50045 SIGMA54_INTERACT_4 # Pfam PF00158 Sigma54_activat # Pfam PF06956 RtcR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RTCR_ECOLI Transcriptional regulatory protein RtcR # RefSeq NP_417880 NC_000913.3 # RefSeq WP_001232948 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=X07520; Type=Erroneous termination; Positions=511; Note=Translated as Leu.; Evidence={ECO:0000305}; Sequence=X07520; Type=Frameshift; Positions=386, 422; Evidence={ECO 0000305}; # SIMILARITY Contains 1 sigma-54 factor interaction domain. {ECO:0000255|PROSITE-ProRule PRU00193}. # SMART SM00382 AAA # SUPFAM SSF52540 SSF52540 # eggNOG COG4650 LUCA # eggNOG ENOG4105CYB Bacteria BLAST swissprot:RTCR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RTCR_ECOLI BioCyc ECOL316407:JW3385-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3385-MONOMER BioCyc EcoCyc:EG12356-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12356-MONOMER COG COG4650 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4650 DIP DIP-10812N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10812N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/ng0694-205 http://dx.doi.org/10.1038/ng0694-205 DOI 10.1074/jbc.273.39.25516 http://dx.doi.org/10.1074/jbc.273.39.25516 DOI 10.1093/nar/16.15.7732 http://dx.doi.org/10.1093/nar/16.15.7732 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M96795 http://www.ebi.ac.uk/ena/data/view/M96795 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X07520 http://www.ebi.ac.uk/ena/data/view/X07520 EchoBASE EB2259 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2259 EcoGene EG12356 http://www.ecogene.org/geneInfo.php?eg_id=EG12356 EnsemblBacteria AAC76447 http://www.ensemblgenomes.org/id/AAC76447 EnsemblBacteria AAC76447 http://www.ensemblgenomes.org/id/AAC76447 EnsemblBacteria BAE77870 http://www.ensemblgenomes.org/id/BAE77870 EnsemblBacteria BAE77870 http://www.ensemblgenomes.org/id/BAE77870 EnsemblBacteria BAE77870 http://www.ensemblgenomes.org/id/BAE77870 EnsemblBacteria b3422 http://www.ensemblgenomes.org/id/b3422 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947928 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947928 HOGENOM HOG000145396 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000145396&db=HOGENOM6 InParanoid P38035 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P38035 IntAct P38035 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P38035* InterPro IPR002078 http://www.ebi.ac.uk/interpro/entry/IPR002078 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR009715 http://www.ebi.ac.uk/interpro/entry/IPR009715 InterPro IPR017183 http://www.ebi.ac.uk/interpro/entry/IPR017183 InterPro IPR025943 http://www.ebi.ac.uk/interpro/entry/IPR025943 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW3385 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3385 KEGG_Gene eco:b3422 http://www.genome.jp/dbget-bin/www_bget?eco:b3422 KEGG_Orthology KO:K14414 http://www.genome.jp/dbget-bin/www_bget?KO:K14414 OMA YLVHITT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YLVHITT PANTHER PTHR32071:SF14 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32071:SF14 PROSITE PS00676 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00676 PROSITE PS50045 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50045 PSORT swissprot:RTCR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RTCR_ECOLI PSORT-B swissprot:RTCR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RTCR_ECOLI PSORT2 swissprot:RTCR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RTCR_ECOLI Pfam PF00158 http://pfam.xfam.org/family/PF00158 Pfam PF06956 http://pfam.xfam.org/family/PF06956 Phobius swissprot:RTCR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RTCR_ECOLI PhylomeDB P38035 http://phylomedb.org/?seqid=P38035 ProteinModelPortal P38035 http://www.proteinmodelportal.org/query/uniprot/P38035 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3045764 http://www.ncbi.nlm.nih.gov/pubmed/3045764 PubMed 7920643 http://www.ncbi.nlm.nih.gov/pubmed/7920643 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9738023 http://www.ncbi.nlm.nih.gov/pubmed/9738023 RefSeq NP_417880 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417880 RefSeq WP_001232948 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001232948 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P38035 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P38035 STRING 511145.b3422 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3422&targetmode=cogs STRING COG4650 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4650&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB RTCR_ECOLI http://www.uniprot.org/uniprot/RTCR_ECOLI UniProtKB-AC P38035 http://www.uniprot.org/uniprot/P38035 charge swissprot:RTCR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RTCR_ECOLI eggNOG COG4650 http://eggnogapi.embl.de/nog_data/html/tree/COG4650 eggNOG ENOG4105CYB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CYB epestfind swissprot:RTCR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RTCR_ECOLI garnier swissprot:RTCR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RTCR_ECOLI helixturnhelix swissprot:RTCR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RTCR_ECOLI hmoment swissprot:RTCR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RTCR_ECOLI iep swissprot:RTCR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RTCR_ECOLI inforesidue swissprot:RTCR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RTCR_ECOLI octanol swissprot:RTCR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RTCR_ECOLI pepcoil swissprot:RTCR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RTCR_ECOLI pepdigest swissprot:RTCR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RTCR_ECOLI pepinfo swissprot:RTCR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RTCR_ECOLI pepnet swissprot:RTCR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RTCR_ECOLI pepstats swissprot:RTCR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RTCR_ECOLI pepwheel swissprot:RTCR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RTCR_ECOLI pepwindow swissprot:RTCR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RTCR_ECOLI sigcleave swissprot:RTCR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RTCR_ECOLI ## Database ID URL or Descriptions # BioGrid 4262690 5 # EcoGene EG12176 yjdC # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0000976 transcription regulatory region sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IBA:GO_Central. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.357.10 -; 1. # InterPro IPR001647 HTH_TetR # InterPro IPR009057 Homeodomain-like # InterPro IPR011075 Tet_transcr_reg_TetR-rel_C # InterPro IPR015893 Tet_transcr_reg_TetR-like_C # Organism YJDC_ECOLI Escherichia coli (strain K12) # PATRIC 32123837 VBIEscCol129921_4266 # PROSITE PS50977 HTH_TETR_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJDC_ECOLI HTH-type transcriptional regulator YjdC # RefSeq NP_418558 NC_000913.3 # RefSeq WP_001188520 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97034.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA85376.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Contains 1 HTH tetR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00335}. # SUPFAM SSF46689 SSF46689 # SUPFAM SSF48498 SSF48498 # eggNOG COG1309 LUCA # eggNOG ENOG4108SIC Bacteria BLAST swissprot:YJDC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJDC_ECOLI BioCyc ECOL316407:JW5733-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5733-MONOMER BioCyc EcoCyc:EG12176-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12176-MONOMER DIP DIP-48209N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48209N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1111/j.1365-2958.1995.tb02286.x http://dx.doi.org/10.1111/j.1365-2958.1995.tb02286.x DOI 10.1111/j.1365-2958.1995.tb02287.x http://dx.doi.org/10.1111/j.1365-2958.1995.tb02287.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M67452 http://www.ebi.ac.uk/ena/data/view/M67452 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X77707 http://www.ebi.ac.uk/ena/data/view/X77707 EMBL Z36905 http://www.ebi.ac.uk/ena/data/view/Z36905 EchoBASE EB2093 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2093 EcoGene EG12176 http://www.ecogene.org/geneInfo.php?eg_id=EG12176 EnsemblBacteria AAC77095 http://www.ensemblgenomes.org/id/AAC77095 EnsemblBacteria AAC77095 http://www.ensemblgenomes.org/id/AAC77095 EnsemblBacteria BAE78137 http://www.ensemblgenomes.org/id/BAE78137 EnsemblBacteria BAE78137 http://www.ensemblgenomes.org/id/BAE78137 EnsemblBacteria BAE78137 http://www.ensemblgenomes.org/id/BAE78137 EnsemblBacteria b4135 http://www.ensemblgenomes.org/id/b4135 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000976 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000976 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.357.10 http://www.cathdb.info/version/latest/superfamily/1.10.357.10 GeneID 948650 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948650 HOGENOM HOG000127273 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000127273&db=HOGENOM6 InParanoid P0ACU7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACU7 InterPro IPR001647 http://www.ebi.ac.uk/interpro/entry/IPR001647 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR011075 http://www.ebi.ac.uk/interpro/entry/IPR011075 InterPro IPR015893 http://www.ebi.ac.uk/interpro/entry/IPR015893 KEGG_Gene ecj:JW5733 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5733 KEGG_Gene eco:b4135 http://www.genome.jp/dbget-bin/www_bget?eco:b4135 OMA CSFYPQP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CSFYPQP PROSITE PS50977 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50977 PSORT swissprot:YJDC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJDC_ECOLI PSORT-B swissprot:YJDC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJDC_ECOLI PSORT2 swissprot:YJDC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJDC_ECOLI Phobius swissprot:YJDC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJDC_ECOLI PhylomeDB P0ACU7 http://phylomedb.org/?seqid=P0ACU7 ProteinModelPortal P0ACU7 http://www.proteinmodelportal.org/query/uniprot/P0ACU7 PubMed 1370290 http://www.ncbi.nlm.nih.gov/pubmed/1370290 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 7623666 http://www.ncbi.nlm.nih.gov/pubmed/7623666 PubMed 7623667 http://www.ncbi.nlm.nih.gov/pubmed/7623667 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418558 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418558 RefSeq WP_001188520 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001188520 SMR P0ACU7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACU7 STRING 511145.b4135 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4135&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF48498 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48498 SWISS-2DPAGE P0ACU7 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0ACU7 UniProtKB YJDC_ECOLI http://www.uniprot.org/uniprot/YJDC_ECOLI UniProtKB-AC P0ACU7 http://www.uniprot.org/uniprot/P0ACU7 charge swissprot:YJDC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJDC_ECOLI eggNOG COG1309 http://eggnogapi.embl.de/nog_data/html/tree/COG1309 eggNOG ENOG4108SIC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108SIC epestfind swissprot:YJDC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJDC_ECOLI garnier swissprot:YJDC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJDC_ECOLI helixturnhelix swissprot:YJDC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJDC_ECOLI hmoment swissprot:YJDC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJDC_ECOLI iep swissprot:YJDC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJDC_ECOLI inforesidue swissprot:YJDC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJDC_ECOLI octanol swissprot:YJDC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJDC_ECOLI pepcoil swissprot:YJDC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJDC_ECOLI pepdigest swissprot:YJDC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJDC_ECOLI pepinfo swissprot:YJDC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJDC_ECOLI pepnet swissprot:YJDC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJDC_ECOLI pepstats swissprot:YJDC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJDC_ECOLI pepwheel swissprot:YJDC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJDC_ECOLI pepwindow swissprot:YJDC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJDC_ECOLI sigcleave swissprot:YJDC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJDC_ECOLI ## Database ID URL or Descriptions # AltName SSPB_ECOLI Adapter protein SspB # AltName SSPB_ECOLI Specificity-enhancing factor SspB # BioGrid 4262444 74 # DISRUPTION PHENOTYPE SSPB_ECOLI Decreased degradation of ssrA-tagged proteins by ClpX-ClpP, no effect on degradation by ClpA-ClpP protease. Delayed and decreased induction of the extracytoplasmic- stress response. {ECO 0000269|PubMed 11009422, ECO 0000269|PubMed 15371343}. # EcoGene EG10978 sspB # FUNCTION SSPB_ECOLI Also stimulates degradation of the N-terminus of RseA (residues 1-108, alone or in complex with sigma-E) by ClpX-ClpP in a non-ssrA-mediated fashion. # FUNCTION SSPB_ECOLI Enhances recognition of ssrA-tagged proteins by the ClpX-ClpP protease; the ssrA degradation tag (AANDENYALAA) is added trans-translationally to proteins that are stalled on the ribosome, freeing the ribosome and targeting stalled peptides for degradation. SspB activates the ATPase activity of ClpX. Seems to act in concert with SspA in the regulation of several proteins during exponential and stationary-phase growth. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005840 ribosome; IDA:EcoCyc. # GO_process GO:0045732 positive regulation of protein catabolic process; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005840 ribosome # GOslim_process GO:0008150 biological_process # Gene3D 2.30.30.220 -; 1. # INDUCTION By amino acid starvation. {ECO:0000269|PubMed 8022275}. # IntAct P0AFZ3 31 # InterPro IPR007481 SspB # Organism SSPB_ECOLI Escherichia coli (strain K12) # PATRIC 32121880 VBIEscCol129921_3324 # PDB 1OX8 X-ray; 2.20 A; A/B=5-111 # PDB 1OX9 X-ray; 2.90 A; A/B/C/D/E/F/G/H=4-111 # PDB 1YFN X-ray; 1.80 A; A/B/C/D=1-118 # PDB 2DS8 X-ray; 1.60 A; P/Q=159-165 # PIR JS0666 JS0666 # PIRSF PIRSF005276 SspB # Pfam PF04386 SspB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SSPB_ECOLI Stringent starvation protein B # RefSeq NP_417695 NC_000913.3 # RefSeq WP_000366129 NZ_LN832404.1 # SIMILARITY Belongs to the SspB family. {ECO 0000305}. # SUBUNIT SSPB_ECOLI Homodimer. Binds 1 ssrA-tag per monomer; if the first Asn residue of the ssrA tag is mutated to Ala, SspB no longer binds the protein or stimulates ClpX-ClpP degradation (PubMed 11009422). Binds the N-terminus (residues 1-108) of RseA with and without sigma-E (PubMed 15371343); although ssrA and the N-terminal fragment of RseA both bind to SspB competitively they bind in opposite directions in its peptide-binding groove. {ECO 0000269|PubMed 11009422, ECO 0000269|PubMed 12887894, ECO 0000269|PubMed 15371343, ECO 0000269|PubMed 15880122, ECO 0000269|PubMed 17258768}. # SUPFAM SSF101738 SSF101738 # eggNOG COG2969 LUCA # eggNOG ENOG4105KB2 Bacteria BLAST swissprot:SSPB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SSPB_ECOLI BioCyc ECOL316407:JW3197-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3197-MONOMER BioCyc EcoCyc:EG10978-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10978-MONOMER COG COG2969 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2969 DIP DIP-29563N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-29563N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0378-1119(91)90584-X http://dx.doi.org/10.1016/0378-1119(91)90584-X DOI 10.1016/S1097-2765(03)00271-5 http://dx.doi.org/10.1016/S1097-2765(03)00271-5 DOI 10.1016/j.jmb.2007.01.003 http://dx.doi.org/10.1016/j.jmb.2007.01.003 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsmb934 http://dx.doi.org/10.1038/nsmb934 DOI 10.1093/nar/15.3.1153 http://dx.doi.org/10.1093/nar/15.3.1153 DOI 10.1101/gad.1240104 http://dx.doi.org/10.1101/gad.1240104 DOI 10.1111/j.1365-2958.1994.tb00381.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb00381.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1126/science.289.5488.2354 http://dx.doi.org/10.1126/science.289.5488.2354 DisProt DP00194 http://www.disprot.org/protein.php?id=DP00194 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M69028 http://www.ebi.ac.uk/ena/data/view/M69028 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X05088 http://www.ebi.ac.uk/ena/data/view/X05088 EchoBASE EB0971 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0971 EcoGene EG10978 http://www.ecogene.org/geneInfo.php?eg_id=EG10978 EnsemblBacteria AAC76260 http://www.ensemblgenomes.org/id/AAC76260 EnsemblBacteria AAC76260 http://www.ensemblgenomes.org/id/AAC76260 EnsemblBacteria BAE77271 http://www.ensemblgenomes.org/id/BAE77271 EnsemblBacteria BAE77271 http://www.ensemblgenomes.org/id/BAE77271 EnsemblBacteria BAE77271 http://www.ensemblgenomes.org/id/BAE77271 EnsemblBacteria b3228 http://www.ensemblgenomes.org/id/b3228 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005840 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005840 GO_process GO:0045732 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045732 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005840 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005840 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 2.30.30.220 http://www.cathdb.info/version/latest/superfamily/2.30.30.220 GeneID 944774 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944774 HOGENOM HOG000255240 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000255240&db=HOGENOM6 InParanoid P0AFZ3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFZ3 IntAct P0AFZ3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFZ3* InterPro IPR007481 http://www.ebi.ac.uk/interpro/entry/IPR007481 KEGG_Gene ecj:JW3197 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3197 KEGG_Gene eco:b3228 http://www.genome.jp/dbget-bin/www_bget?eco:b3228 KEGG_Orthology KO:K03600 http://www.genome.jp/dbget-bin/www_bget?KO:K03600 MINT MINT-1226453 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1226453 OMA PHTLYVP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PHTLYVP PDB 1OX8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1OX8 PDB 1OX9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1OX9 PDB 1YFN http://www.ebi.ac.uk/pdbe-srv/view/entry/1YFN PDB 2DS8 http://www.ebi.ac.uk/pdbe-srv/view/entry/2DS8 PDBsum 1OX8 http://www.ebi.ac.uk/pdbsum/1OX8 PDBsum 1OX9 http://www.ebi.ac.uk/pdbsum/1OX9 PDBsum 1YFN http://www.ebi.ac.uk/pdbsum/1YFN PDBsum 2DS8 http://www.ebi.ac.uk/pdbsum/2DS8 PSORT swissprot:SSPB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SSPB_ECOLI PSORT-B swissprot:SSPB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SSPB_ECOLI PSORT2 swissprot:SSPB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SSPB_ECOLI Pfam PF04386 http://pfam.xfam.org/family/PF04386 Phobius swissprot:SSPB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SSPB_ECOLI PhylomeDB P0AFZ3 http://phylomedb.org/?seqid=P0AFZ3 ProteinModelPortal P0AFZ3 http://www.proteinmodelportal.org/query/uniprot/P0AFZ3 PubMed 11009422 http://www.ncbi.nlm.nih.gov/pubmed/11009422 PubMed 12887894 http://www.ncbi.nlm.nih.gov/pubmed/12887894 PubMed 15371343 http://www.ncbi.nlm.nih.gov/pubmed/15371343 PubMed 15880122 http://www.ncbi.nlm.nih.gov/pubmed/15880122 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1721886 http://www.ncbi.nlm.nih.gov/pubmed/1721886 PubMed 17258768 http://www.ncbi.nlm.nih.gov/pubmed/17258768 PubMed 3029697 http://www.ncbi.nlm.nih.gov/pubmed/3029697 PubMed 8022275 http://www.ncbi.nlm.nih.gov/pubmed/8022275 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417695 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417695 RefSeq WP_000366129 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000366129 SMR P0AFZ3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFZ3 STRING 511145.b3228 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3228&targetmode=cogs STRING COG2969 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2969&targetmode=cogs SUPFAM SSF101738 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF101738 SWISS-2DPAGE P0AFZ3 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AFZ3 UniProtKB SSPB_ECOLI http://www.uniprot.org/uniprot/SSPB_ECOLI UniProtKB-AC P0AFZ3 http://www.uniprot.org/uniprot/P0AFZ3 charge swissprot:SSPB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SSPB_ECOLI eggNOG COG2969 http://eggnogapi.embl.de/nog_data/html/tree/COG2969 eggNOG ENOG4105KB2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KB2 epestfind swissprot:SSPB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SSPB_ECOLI garnier swissprot:SSPB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SSPB_ECOLI helixturnhelix swissprot:SSPB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SSPB_ECOLI hmoment swissprot:SSPB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SSPB_ECOLI iep swissprot:SSPB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SSPB_ECOLI inforesidue swissprot:SSPB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SSPB_ECOLI octanol swissprot:SSPB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SSPB_ECOLI pepcoil swissprot:SSPB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SSPB_ECOLI pepdigest swissprot:SSPB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SSPB_ECOLI pepinfo swissprot:SSPB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SSPB_ECOLI pepnet swissprot:SSPB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SSPB_ECOLI pepstats swissprot:SSPB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SSPB_ECOLI pepwheel swissprot:SSPB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SSPB_ECOLI pepwindow swissprot:SSPB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SSPB_ECOLI sigcleave swissprot:SSPB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SSPB_ECOLI ## Database ID URL or Descriptions # AltName BFR_ECOLI Cytochrome b-1 # AltName BFR_ECOLI Cytochrome b-557 # BRENDA 1.16.3 2026 # BioGrid 4262466 15 # CATALYTIC ACTIVITY BFR_ECOLI 4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O. {ECO 0000269|PubMed 10769150, ECO 0000269|PubMed 14636073, ECO 0000269|PubMed 19705876}. # CDD cd00907 Bacterioferritin # COFACTOR BFR_ECOLI Name=Fe cation; Xref=ChEBI CHEBI 24875; Evidence={ECO 0000269|PubMed 19391621}; Note=Binds 2 iron ions per subunit. The catalytic dinuclear iron- binding site within each subunit is known as the ferroxidase center. In BFR, the ferroxidase center appears to function as a true di-iron catalytic cofactor, rather than as a pore for the transfer of iron into the central cavity, as found for eukaryotic ferritins. {ECO 0000269|PubMed 19391621}; # COFACTOR BFR_ECOLI Name=heme b; Xref=ChEBI CHEBI 60344; Evidence={ECO 0000269|PubMed 19391621}; Note=Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer. {ECO 0000269|PubMed 19391621}; # ENZYME REGULATION BFR_ECOLI Iron oxidation is inhibited by Zn(2+), which binds at the ferroxidase center with a higher affinity that Fe(2+). The occupation of the ferroxidase center by Zn(2+) also severely restricts the ability of BFR to form an iron core. {ECO 0000269|PubMed 10769150, ECO 0000269|PubMed 14636073, ECO 0000269|PubMed 19705876}. # EcoGene EG10113 bfr # FUNCTION BFR_ECOLI Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex. The mineralized iron core can contain as many as 2700 iron atoms/24-meric molecule. {ECO 0000269|PubMed 10769150, ECO 0000269|PubMed 14636073}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0005886 plasma membrane; TAS:Reactome. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0004322 ferroxidase activity; TAS:Reactome. # GO_function GO:0005506 iron ion binding; IDA:EcoCyc. # GO_function GO:0008199 ferric iron binding; IEA:InterPro. # GO_function GO:0016491 oxidoreductase activity; NAS:EcoliWiki. # GO_function GO:0020037 heme binding; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0006826 iron ion transport; IEA:InterPro. # GO_process GO:0006880 intracellular sequestering of iron ion; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # Gene3D 1.20.1260.10 -; 1. # IntAct P0ABD3 2 # InterPro IPR002024 Bacterioferritin # InterPro IPR008331 Ferritin_DPS_dom # InterPro IPR009040 Ferritin-like_diiron # InterPro IPR009078 Ferritin-like_SF # InterPro IPR012347 Ferritin-rel # MASS SPECTROMETRY Mass=18496; Mass_error=2; Method=Electrospray; Range=1-158; Evidence={ECO:0000269|PubMed 7559480}; # MISCELLANEOUS BFR_ECOLI The internal surface iron site that binds iron 3 is important for the mineralization phase but not for Fe(2+) binding and oxidation at the ferroxidase center. # Organism BFR_ECOLI Escherichia coli (strain K12) # PATRIC 32122104 VBIEscCol129921_3429 # PDB 1BCF X-ray; 2.90 A; A/B/C/D/E/F/G/H/I/J/K/L=1-158 # PDB 1BFR X-ray; 2.94 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=1-158 # PDB 2HTN X-ray; 2.50 A; A/B/C/D/E/F/G/H=1-158 # PDB 2VXI X-ray; 1.91 A; A/B/C/D/E/F/G/H/I/J/K/L=1-158 # PDB 2Y3Q X-ray; 1.55 A; A/B/C/D/E/F/G/H/I/J/K/L=1-158 # PDB 3E1J X-ray; 2.70 A; A/B/C/D/E/F/G/H/I/J/K/L=1-158 # PDB 3E1L X-ray; 2.50 A; A/B/C/D/E/F/G/H/I/J/K/L=1-158 # PDB 3E1M X-ray; 2.70 A; A/B/C/D/E/F/G/H/I/J/K/L=1-158 # PDB 3E1N X-ray; 2.80 A; A/B/C/D/E/F/G/H/I/J/K/L=1-158 # PDB 3E1O X-ray; 2.95 A; A/B/C/D/E/F/G/H/I/J/K/L=1-158 # PDB 3E1P X-ray; 2.40 A; A/B/C/D/E/F/G/H/I/J/K/L=1-158 # PDB 3E1Q X-ray; 2.60 A; A/B/C/D/E/F/G/H/I/J/K/L=1-158 # PDB 3E2C X-ray; 1.80 A; A/B=1-158 # PDB 3GHQ X-ray; 2.70 A; A/B/C/D/E/F/G/H/I/J/K/L=1-158 # PDB 4CVP X-ray; 2.11 A; A=1-158 # PDB 4CVR X-ray; 1.10 A; A=1-158 # PDB 4CVS X-ray; 1.39 A; A=1-158 # PDB 4CVT X-ray; 1.79 A; A=1-158 # PDB 4U3G X-ray; 2.00 A; A/B/C/D/E/F/G/H/I/J/K/L=1-158 # PDB 4XKS X-ray; 1.57 A; A/B/C/D/E/F/G/H/I/J/K/L=1-158 # PDB 4XKT X-ray; 1.82 A; A/B/C/D/E/F/G/H/I/J/K/L=1-158 # PDB 4XKU X-ray; 1.78 A; A/B/C/D/E/F/G/H/I/J/K/L=1-158 # PIR JV0032 FREC # PIRSF PIRSF002560 Bacterioferritin # PRINTS PR00601 BACFERRITIN # PROSITE PS00549 BACTERIOFERRITIN # PROSITE PS50905 FERRITIN_LIKE # Pfam PF00210 Ferritin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BFR_ECOLI Bacterioferritin # RefSeq NP_417795 NC_000913.3 # RefSeq WP_000675504 NZ_LN832404.1 # SIMILARITY Belongs to the bacterioferritin family. {ECO 0000305}. # SIMILARITY Contains 1 ferritin-like diiron domain. {ECO:0000255|PROSITE-ProRule PRU00085}. # SUBUNIT BFR_ECOLI Homooligomer of 24 subunits, arranged as 12 dimers, that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be deposited as a ferric-oxy-hydroxide mineral core. {ECO 0000269|PubMed 17077480, ECO 0000269|PubMed 18946693, ECO 0000269|PubMed 19439409, ECO 0000269|PubMed 19705876, ECO 0000269|PubMed 21215826, ECO 0000269|PubMed 7664064, ECO 0000269|PubMed 9867433}. # SUPFAM SSF47240 SSF47240 # TIGRFAMs TIGR00754 bfr # eggNOG COG2193 LUCA # eggNOG ENOG4108UQY Bacteria BLAST swissprot:BFR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BFR_ECOLI BioCyc ECOL316407:JW3298-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3298-MONOMER BioCyc EcoCyc:EG10113-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10113-MONOMER BioCyc MetaCyc:EG10113-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10113-MONOMER COG COG2193 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2193 DIP DIP-36167N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36167N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1007/s00775-008-0438-8 http://dx.doi.org/10.1007/s00775-008-0438-8 DOI 10.1016/0378-1119(94)90851-6 http://dx.doi.org/10.1016/0378-1119(94)90851-6 DOI 10.1016/S0006-291X(89)80075-0 http://dx.doi.org/10.1016/S0006-291X(89)80075-0 DOI 10.1016/j.bbapap.2010.12.017 http://dx.doi.org/10.1016/j.bbapap.2010.12.017 DOI 10.1021/bi035253u http://dx.doi.org/10.1021/bi035253u DOI 10.1021/bi900869x http://dx.doi.org/10.1021/bi900869x DOI 10.1021/bi992631f http://dx.doi.org/10.1021/bi992631f DOI 10.1021/ja8093444 http://dx.doi.org/10.1021/ja8093444 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb0794-453 http://dx.doi.org/10.1038/nsb0794-453 DOI 10.1074/jbc.270.40.23268 http://dx.doi.org/10.1074/jbc.270.40.23268 DOI 10.1074/jbc.M901747200 http://dx.doi.org/10.1074/jbc.M901747200 DOI 10.1107/S0907444997006811 http://dx.doi.org/10.1107/S0907444997006811 DOI 10.1107/S1744309106039583 http://dx.doi.org/10.1107/S1744309106039583 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.16.3.1 http://www.genome.jp/dbget-bin/www_bget?EC:1.16.3.1 EMBL AF058450 http://www.ebi.ac.uk/ena/data/view/AF058450 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L28106 http://www.ebi.ac.uk/ena/data/view/L28106 EMBL M27176 http://www.ebi.ac.uk/ena/data/view/M27176 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 1.16.3.1 http://enzyme.expasy.org/EC/1.16.3.1 EchoBASE EB0111 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0111 EcoGene EG10113 http://www.ecogene.org/geneInfo.php?eg_id=EG10113 EnsemblBacteria AAC76361 http://www.ensemblgenomes.org/id/AAC76361 EnsemblBacteria AAC76361 http://www.ensemblgenomes.org/id/AAC76361 EnsemblBacteria BAE77955 http://www.ensemblgenomes.org/id/BAE77955 EnsemblBacteria BAE77955 http://www.ensemblgenomes.org/id/BAE77955 EnsemblBacteria BAE77955 http://www.ensemblgenomes.org/id/BAE77955 EnsemblBacteria b3336 http://www.ensemblgenomes.org/id/b3336 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0004322 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004322 GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0008199 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008199 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0020037 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0020037 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0006826 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006826 GO_process GO:0006880 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006880 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.20.1260.10 http://www.cathdb.info/version/latest/superfamily/1.20.1260.10 GeneID 947839 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947839 HOGENOM HOG000262383 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000262383&db=HOGENOM6 InParanoid P0ABD3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABD3 IntAct P0ABD3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABD3* IntEnz 1.16.3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.16.3.1 InterPro IPR002024 http://www.ebi.ac.uk/interpro/entry/IPR002024 InterPro IPR008331 http://www.ebi.ac.uk/interpro/entry/IPR008331 InterPro IPR009040 http://www.ebi.ac.uk/interpro/entry/IPR009040 InterPro IPR009078 http://www.ebi.ac.uk/interpro/entry/IPR009078 InterPro IPR012347 http://www.ebi.ac.uk/interpro/entry/IPR012347 KEGG_Gene ecj:JW3298 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3298 KEGG_Gene eco:b3336 http://www.genome.jp/dbget-bin/www_bget?eco:b3336 KEGG_Orthology KO:K03594 http://www.genome.jp/dbget-bin/www_bget?KO:K03594 OMA EMKHADQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EMKHADQ PDB 1BCF http://www.ebi.ac.uk/pdbe-srv/view/entry/1BCF PDB 1BFR http://www.ebi.ac.uk/pdbe-srv/view/entry/1BFR PDB 2HTN http://www.ebi.ac.uk/pdbe-srv/view/entry/2HTN PDB 2VXI http://www.ebi.ac.uk/pdbe-srv/view/entry/2VXI PDB 2Y3Q http://www.ebi.ac.uk/pdbe-srv/view/entry/2Y3Q PDB 3E1J http://www.ebi.ac.uk/pdbe-srv/view/entry/3E1J PDB 3E1L http://www.ebi.ac.uk/pdbe-srv/view/entry/3E1L PDB 3E1M http://www.ebi.ac.uk/pdbe-srv/view/entry/3E1M PDB 3E1N http://www.ebi.ac.uk/pdbe-srv/view/entry/3E1N PDB 3E1O http://www.ebi.ac.uk/pdbe-srv/view/entry/3E1O PDB 3E1P http://www.ebi.ac.uk/pdbe-srv/view/entry/3E1P PDB 3E1Q http://www.ebi.ac.uk/pdbe-srv/view/entry/3E1Q PDB 3E2C http://www.ebi.ac.uk/pdbe-srv/view/entry/3E2C PDB 3GHQ http://www.ebi.ac.uk/pdbe-srv/view/entry/3GHQ PDB 4CVP http://www.ebi.ac.uk/pdbe-srv/view/entry/4CVP PDB 4CVR http://www.ebi.ac.uk/pdbe-srv/view/entry/4CVR PDB 4CVS http://www.ebi.ac.uk/pdbe-srv/view/entry/4CVS PDB 4CVT http://www.ebi.ac.uk/pdbe-srv/view/entry/4CVT PDB 4U3G http://www.ebi.ac.uk/pdbe-srv/view/entry/4U3G PDB 4XKS http://www.ebi.ac.uk/pdbe-srv/view/entry/4XKS PDB 4XKT http://www.ebi.ac.uk/pdbe-srv/view/entry/4XKT PDB 4XKU http://www.ebi.ac.uk/pdbe-srv/view/entry/4XKU PDBsum 1BCF http://www.ebi.ac.uk/pdbsum/1BCF PDBsum 1BFR http://www.ebi.ac.uk/pdbsum/1BFR PDBsum 2HTN http://www.ebi.ac.uk/pdbsum/2HTN PDBsum 2VXI http://www.ebi.ac.uk/pdbsum/2VXI PDBsum 2Y3Q http://www.ebi.ac.uk/pdbsum/2Y3Q PDBsum 3E1J http://www.ebi.ac.uk/pdbsum/3E1J PDBsum 3E1L http://www.ebi.ac.uk/pdbsum/3E1L PDBsum 3E1M http://www.ebi.ac.uk/pdbsum/3E1M PDBsum 3E1N http://www.ebi.ac.uk/pdbsum/3E1N PDBsum 3E1O http://www.ebi.ac.uk/pdbsum/3E1O PDBsum 3E1P http://www.ebi.ac.uk/pdbsum/3E1P PDBsum 3E1Q http://www.ebi.ac.uk/pdbsum/3E1Q PDBsum 3E2C http://www.ebi.ac.uk/pdbsum/3E2C PDBsum 3GHQ http://www.ebi.ac.uk/pdbsum/3GHQ PDBsum 4CVP http://www.ebi.ac.uk/pdbsum/4CVP PDBsum 4CVR http://www.ebi.ac.uk/pdbsum/4CVR PDBsum 4CVS http://www.ebi.ac.uk/pdbsum/4CVS PDBsum 4CVT http://www.ebi.ac.uk/pdbsum/4CVT PDBsum 4U3G http://www.ebi.ac.uk/pdbsum/4U3G PDBsum 4XKS http://www.ebi.ac.uk/pdbsum/4XKS PDBsum 4XKT http://www.ebi.ac.uk/pdbsum/4XKT PDBsum 4XKU http://www.ebi.ac.uk/pdbsum/4XKU PRINTS PR00601 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00601 PROSITE PS00549 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00549 PROSITE PS50905 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50905 PSORT swissprot:BFR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BFR_ECOLI PSORT-B swissprot:BFR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BFR_ECOLI PSORT2 swissprot:BFR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BFR_ECOLI Pfam PF00210 http://pfam.xfam.org/family/PF00210 Phobius swissprot:BFR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BFR_ECOLI PhylomeDB P0ABD3 http://phylomedb.org/?seqid=P0ABD3 ProteinModelPortal P0ABD3 http://www.proteinmodelportal.org/query/uniprot/P0ABD3 PubMed 10769150 http://www.ncbi.nlm.nih.gov/pubmed/10769150 PubMed 14636073 http://www.ncbi.nlm.nih.gov/pubmed/14636073 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17077480 http://www.ncbi.nlm.nih.gov/pubmed/17077480 PubMed 18946693 http://www.ncbi.nlm.nih.gov/pubmed/18946693 PubMed 19391621 http://www.ncbi.nlm.nih.gov/pubmed/19391621 PubMed 19439409 http://www.ncbi.nlm.nih.gov/pubmed/19439409 PubMed 19705876 http://www.ncbi.nlm.nih.gov/pubmed/19705876 PubMed 21215826 http://www.ncbi.nlm.nih.gov/pubmed/21215826 PubMed 2644932 http://www.ncbi.nlm.nih.gov/pubmed/2644932 PubMed 2661540 http://www.ncbi.nlm.nih.gov/pubmed/2661540 PubMed 7559480 http://www.ncbi.nlm.nih.gov/pubmed/7559480 PubMed 7664064 http://www.ncbi.nlm.nih.gov/pubmed/7664064 PubMed 7959070 http://www.ncbi.nlm.nih.gov/pubmed/7959070 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9867433 http://www.ncbi.nlm.nih.gov/pubmed/9867433 RefSeq NP_417795 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417795 RefSeq WP_000675504 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000675504 SMR P0ABD3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABD3 STRING 511145.b3336 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3336&targetmode=cogs STRING COG2193 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2193&targetmode=cogs SUPFAM SSF47240 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47240 TIGRFAMs TIGR00754 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00754 UniProtKB BFR_ECOLI http://www.uniprot.org/uniprot/BFR_ECOLI UniProtKB-AC P0ABD3 http://www.uniprot.org/uniprot/P0ABD3 charge swissprot:BFR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BFR_ECOLI eggNOG COG2193 http://eggnogapi.embl.de/nog_data/html/tree/COG2193 eggNOG ENOG4108UQY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UQY epestfind swissprot:BFR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BFR_ECOLI garnier swissprot:BFR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BFR_ECOLI helixturnhelix swissprot:BFR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BFR_ECOLI hmoment swissprot:BFR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BFR_ECOLI iep swissprot:BFR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BFR_ECOLI inforesidue swissprot:BFR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BFR_ECOLI octanol swissprot:BFR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BFR_ECOLI pepcoil swissprot:BFR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BFR_ECOLI pepdigest swissprot:BFR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BFR_ECOLI pepinfo swissprot:BFR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BFR_ECOLI pepnet swissprot:BFR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BFR_ECOLI pepstats swissprot:BFR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BFR_ECOLI pepwheel swissprot:BFR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BFR_ECOLI pepwindow swissprot:BFR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BFR_ECOLI sigcleave swissprot:BFR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BFR_ECOLI ## Database ID URL or Descriptions # BioGrid 4262721 206 # CDD cd06174 MFS # EcoGene EG12544 yjhB # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0046943 carboxylic acid transmembrane transporter activity; IBA:GO_Central. # GO_process GO:0015992 proton transport; IBA:GO_Central. # GO_process GO:0046942 carboxylic acid transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # Organism YJHB_ECOLI Escherichia coli (strain K12) # PATRIC 32124131 VBIEscCol129921_4409 # PDB 4J09 X-ray; 1.90 A; B=101-106 # PIR S56504 S56504 # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJHB_ECOLI Putative metabolite transport protein YjhB # RefSeq NP_418699 NC_000913.3 # RefSeq WP_000179691 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97175.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. {ECO 0000305}. # SUBCELLULAR LOCATION YJHB_ECOLI Cell inner membrane {ECO 0000305}; Multi- pass membrane protein {ECO 0000305}. # SUPFAM SSF103473 SSF103473 # eggNOG ENOG4105JHE Bacteria # eggNOG ENOG410XSSD LUCA BLAST swissprot:YJHB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJHB_ECOLI BioCyc ECOL316407:JW5768-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5768-MONOMER BioCyc EcoCyc:YJHB-MONOMER http://biocyc.org/getid?id=EcoCyc:YJHB-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2432 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2432 EcoGene EG12544 http://www.ecogene.org/geneInfo.php?eg_id=EG12544 EnsemblBacteria AAC77235 http://www.ensemblgenomes.org/id/AAC77235 EnsemblBacteria AAC77235 http://www.ensemblgenomes.org/id/AAC77235 EnsemblBacteria BAE78273 http://www.ensemblgenomes.org/id/BAE78273 EnsemblBacteria BAE78273 http://www.ensemblgenomes.org/id/BAE78273 EnsemblBacteria BAE78273 http://www.ensemblgenomes.org/id/BAE78273 EnsemblBacteria b4279 http://www.ensemblgenomes.org/id/b4279 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0046943 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046943 GO_process GO:0015992 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015992 GO_process GO:0046942 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046942 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948807 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948807 HOGENOM HOG000074791 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000074791&db=HOGENOM6 InParanoid P39352 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39352 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Gene ecj:JW5768 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5768 KEGG_Gene eco:b4279 http://www.genome.jp/dbget-bin/www_bget?eco:b4279 OMA WDFFAVS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WDFFAVS PDB 4J09 http://www.ebi.ac.uk/pdbe-srv/view/entry/4J09 PDBsum 4J09 http://www.ebi.ac.uk/pdbsum/4J09 PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:YJHB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJHB_ECOLI PSORT-B swissprot:YJHB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJHB_ECOLI PSORT2 swissprot:YJHB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJHB_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:YJHB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJHB_ECOLI PhylomeDB P39352 http://phylomedb.org/?seqid=P39352 ProteinModelPortal P39352 http://www.proteinmodelportal.org/query/uniprot/P39352 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418699 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418699 RefSeq WP_000179691 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000179691 STRING 511145.b4279 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4279&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 UniProtKB YJHB_ECOLI http://www.uniprot.org/uniprot/YJHB_ECOLI UniProtKB-AC P39352 http://www.uniprot.org/uniprot/P39352 charge swissprot:YJHB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJHB_ECOLI eggNOG ENOG4105JHE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105JHE eggNOG ENOG410XSSD http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XSSD epestfind swissprot:YJHB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJHB_ECOLI garnier swissprot:YJHB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJHB_ECOLI helixturnhelix swissprot:YJHB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJHB_ECOLI hmoment swissprot:YJHB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJHB_ECOLI iep swissprot:YJHB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJHB_ECOLI inforesidue swissprot:YJHB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJHB_ECOLI octanol swissprot:YJHB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJHB_ECOLI pepcoil swissprot:YJHB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJHB_ECOLI pepdigest swissprot:YJHB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJHB_ECOLI pepinfo swissprot:YJHB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJHB_ECOLI pepnet swissprot:YJHB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJHB_ECOLI pepstats swissprot:YJHB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJHB_ECOLI pepwheel swissprot:YJHB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJHB_ECOLI pepwindow swissprot:YJHB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJHB_ECOLI sigcleave swissprot:YJHB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJHB_ECOLI ## Database ID URL or Descriptions # BioGrid 4259268 4 # EcoGene EG12782 yraQ # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR005524 DUF318 # Organism YRAQ_ECOLI Escherichia coli (strain K12) # PATRIC 32121720 VBIEscCol129921_3246 # PIR C65105 C65105 # Pfam PF03773 ArsP_1; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YRAQ_ECOLI UPF0718 protein YraQ # RefSeq NP_417620 NC_000913.3 # RefSeq WP_000147574 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0718 family. {ECO 0000305}. # SUBCELLULAR LOCATION YRAQ_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # eggNOG COG0701 LUCA # eggNOG ENOG4107S21 Bacteria BLAST swissprot:YRAQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YRAQ_ECOLI BioCyc ECOL316407:JW3120-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3120-MONOMER BioCyc EcoCyc:G7645-MONOMER http://biocyc.org/getid?id=EcoCyc:G7645-MONOMER COG COG0701 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0701 DIP DIP-12901N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12901N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2635 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2635 EcoGene EG12782 http://www.ecogene.org/geneInfo.php?eg_id=EG12782 EnsemblBacteria AAC76185 http://www.ensemblgenomes.org/id/AAC76185 EnsemblBacteria AAC76185 http://www.ensemblgenomes.org/id/AAC76185 EnsemblBacteria BAE77197 http://www.ensemblgenomes.org/id/BAE77197 EnsemblBacteria BAE77197 http://www.ensemblgenomes.org/id/BAE77197 EnsemblBacteria BAE77197 http://www.ensemblgenomes.org/id/BAE77197 EnsemblBacteria b3151 http://www.ensemblgenomes.org/id/b3151 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 947668 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947668 HOGENOM HOG000260012 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260012&db=HOGENOM6 InParanoid P45468 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45468 IntAct P45468 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45468* InterPro IPR005524 http://www.ebi.ac.uk/interpro/entry/IPR005524 KEGG_Gene ecj:JW3120 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3120 KEGG_Gene eco:b3151 http://www.genome.jp/dbget-bin/www_bget?eco:b3151 KEGG_Orthology KO:K07089 http://www.genome.jp/dbget-bin/www_bget?KO:K07089 MINT MINT-1279227 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1279227 OMA RVWLYIL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RVWLYIL PSORT swissprot:YRAQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YRAQ_ECOLI PSORT-B swissprot:YRAQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YRAQ_ECOLI PSORT2 swissprot:YRAQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YRAQ_ECOLI Pfam PF03773 http://pfam.xfam.org/family/PF03773 Phobius swissprot:YRAQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YRAQ_ECOLI PhylomeDB P45468 http://phylomedb.org/?seqid=P45468 ProteinModelPortal P45468 http://www.proteinmodelportal.org/query/uniprot/P45468 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417620 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417620 RefSeq WP_000147574 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000147574 STRING 511145.b3151 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3151&targetmode=cogs STRING COG0701 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0701&targetmode=cogs UniProtKB YRAQ_ECOLI http://www.uniprot.org/uniprot/YRAQ_ECOLI UniProtKB-AC P45468 http://www.uniprot.org/uniprot/P45468 charge swissprot:YRAQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YRAQ_ECOLI eggNOG COG0701 http://eggnogapi.embl.de/nog_data/html/tree/COG0701 eggNOG ENOG4107S21 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107S21 epestfind swissprot:YRAQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YRAQ_ECOLI garnier swissprot:YRAQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YRAQ_ECOLI helixturnhelix swissprot:YRAQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YRAQ_ECOLI hmoment swissprot:YRAQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YRAQ_ECOLI iep swissprot:YRAQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YRAQ_ECOLI inforesidue swissprot:YRAQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YRAQ_ECOLI octanol swissprot:YRAQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YRAQ_ECOLI pepcoil swissprot:YRAQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YRAQ_ECOLI pepdigest swissprot:YRAQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YRAQ_ECOLI pepinfo swissprot:YRAQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YRAQ_ECOLI pepnet swissprot:YRAQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YRAQ_ECOLI pepstats swissprot:YRAQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YRAQ_ECOLI pepwheel swissprot:YRAQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YRAQ_ECOLI pepwindow swissprot:YRAQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YRAQ_ECOLI sigcleave swissprot:YRAQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YRAQ_ECOLI ## Database ID URL or Descriptions # AltName NADR_ECOLI Nicotinamide ribonucleotide adenylyltransferase # AltName NADR_ECOLI Nicotinamide riboside kinase # AltName NADR_ECOLI Nicotinamide-nucleotide adenylyltransferase # AltName NADR_ECOLI Nicotinamide-nucleotide adenylyltransferase # BIOPHYSICOCHEMICAL PROPERTIES NADR_ECOLI Kinetic parameters KM=0.7 mM for NMN {ECO 0000269|PubMed 10464228}; KM=1.7 uM for ATP {ECO 0000269|PubMed 10464228}; pH dependence Optimum pH is 8.6. {ECO 0000269|PubMed 10464228}; # BioGrid 4260800 3 # CATALYTIC ACTIVITY NADR_ECOLI ATP + 1-(beta-D-ribofuranosyl)-nicotinamide = ADP + beta-nicotinamide D-ribonucleotide. # CATALYTIC ACTIVITY NADR_ECOLI ATP + nicotinamide ribonucleotide = diphosphate + NAD(+). # ENZYME REGULATION Feed-back regulated by NAD. A high level of NAD causes NadR to lose enzymatic activity and repress several NAD synthetic genes; conversely, a low NAD level activates the assimilatory enzymatic activities and leads to derepression of biosynthetic genes (By similarity). {ECO 0000250}. # EcoGene EG11335 nadR # FUNCTION NADR_ECOLI This enzyme has three activities DNA binding, nicotinamide mononucleotide (NMN) adenylyltransferase and ribosylnicotinamide (RN) kinase. The DNA-binding domain binds to the nadB operator sequence in an NAD- and ATP-dependent manner. As NAD levels increase within the cell, the affinity of NadR for the nadB operator regions of nadA, nadB, and pncB increases, repressing the transcription of these genes. The RN kinase activity catalyzes the phosphorylation of RN to form nicotinamide ribonucleotide. The NMN adenylyltransferase activity catalyzes the transfer of the AMP moiety of ATP to nicotinamide ribonucleotide to form NAD(+). The NMN adenylyltransferase domain also functions as the NAD and ATP sensor. {ECO 0000269|PubMed 10464228}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0000309 nicotinamide-nucleotide adenylyltransferase activity; IDA:EcoCyc. # GO_function GO:0000986 bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0050262 ribosylnicotinamide kinase activity; IEA:UniProtKB-EC. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006810 transport; IEA:InterPro. # GO_process GO:0009435 NAD biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IEA:InterPro. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 1.10.260.40 -; 1. # Gene3D 3.40.50.300 -; 1. # Gene3D 3.40.50.620 -; 1. # InterPro IPR001387 Cro/C1-type_HTH # InterPro IPR004821 Cyt_trans-like # InterPro IPR006417 NadR_NMN_Atrans # InterPro IPR010982 Lambda_DNA-bd_dom # InterPro IPR014729 Rossmann-like_a/b/a_fold # InterPro IPR016429 Bifunc_transcrip_reg_NadR # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko03000 Transcription factors # Organism NADR_ECOLI Escherichia coli (strain K12) # PATHWAY Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide step 1/1. # PATHWAY NADR_ECOLI Cofactor biosynthesis; NAD(+) biosynthesis [regulation]. # PATRIC 32124396 VBIEscCol129921_4538 # PIR S56614 S56614 # PIRSF PIRSF004776 NadR_NMNAT/RNK # PROSITE PS50943 HTH_CROC1 # Pfam PF01381 HTH_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NADR_ECOLI Nicotinamide mononucleotide adenylyltransferase # RecName NADR_ECOLI Ribosylnicotinamide kinase # RecName NADR_ECOLI Transcriptional regulator NadR # RecName NADR_ECOLI Transcriptional regulator NadR # RecName NADR_ECOLI Trifunctional NAD biosynthesis/regulator protein NadR # RecName NADR_ECOLI Trifunctional NAD biosynthesis/regulator protein NadR # RefSeq NP_418807 NC_000913.3 # RefSeq WP_000093814 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97286.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Contains 1 HTH cro/C1-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00257}. # SIMILARITY In the C-terminal section; belongs to the bacterial RNK family. {ECO 0000305}. # SIMILARITY In the central section; belongs to the bacterial NMN adenylyltransferase family. {ECO 0000305}. # SMART SM00530 HTH_XRE # SUBCELLULAR LOCATION NADR_ECOLI Cell membrane; Peripheral membrane protein. Cytoplasm {ECO 0000250}. # SUBUNIT Homotetramer. {ECO 0000250}. # SUPFAM SSF47413 SSF47413 # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR00125 cyt_tran_rel # TIGRFAMs TIGR01526 nadR_NMN_Atrans # UniPathway UPA00253 UER00600 # eggNOG COG1056 LUCA # eggNOG COG1396 LUCA # eggNOG COG3172 LUCA # eggNOG ENOG4107VZS Bacteria BLAST swissprot:NADR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NADR_ECOLI BioCyc ECOL316407:JW5800-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5800-MONOMER BioCyc EcoCyc:PD04413 http://biocyc.org/getid?id=EcoCyc:PD04413 BioCyc MetaCyc:PD04413 http://biocyc.org/getid?id=MetaCyc:PD04413 COG COG1056 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1056 COG COG1396 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1396 COG COG3172 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3172 DOI 10.1016/0378-1119(92)90002-7 http://dx.doi.org/10.1016/0378-1119(92)90002-7 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.22 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.22 EC_number EC:2.7.7.1 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X63155 http://www.ebi.ac.uk/ena/data/view/X63155 ENZYME 2.7.1.22 http://enzyme.expasy.org/EC/2.7.1.22 ENZYME 2.7.7.1 http://enzyme.expasy.org/EC/2.7.7.1 EchoBASE EB1311 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1311 EcoGene EG11335 http://www.ecogene.org/geneInfo.php?eg_id=EG11335 EnsemblBacteria AAC77343 http://www.ensemblgenomes.org/id/AAC77343 EnsemblBacteria AAC77343 http://www.ensemblgenomes.org/id/AAC77343 EnsemblBacteria BAE78379 http://www.ensemblgenomes.org/id/BAE78379 EnsemblBacteria BAE78379 http://www.ensemblgenomes.org/id/BAE78379 EnsemblBacteria BAE78379 http://www.ensemblgenomes.org/id/BAE78379 EnsemblBacteria b4390 http://www.ensemblgenomes.org/id/b4390 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0000309 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000309 GO_function GO:0000986 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000986 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0050262 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050262 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GO_process GO:0009435 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009435 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 1.10.260.40 http://www.cathdb.info/version/latest/superfamily/1.10.260.40 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 GeneID 948911 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948911 HOGENOM HOG000127874 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000127874&db=HOGENOM6 InParanoid P27278 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P27278 IntEnz 2.7.1.22 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.22 IntEnz 2.7.7.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.1 InterPro IPR001387 http://www.ebi.ac.uk/interpro/entry/IPR001387 InterPro IPR004821 http://www.ebi.ac.uk/interpro/entry/IPR004821 InterPro IPR006417 http://www.ebi.ac.uk/interpro/entry/IPR006417 InterPro IPR010982 http://www.ebi.ac.uk/interpro/entry/IPR010982 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 InterPro IPR016429 http://www.ebi.ac.uk/interpro/entry/IPR016429 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW5800 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5800 KEGG_Gene eco:b4390 http://www.genome.jp/dbget-bin/www_bget?eco:b4390 KEGG_Orthology KO:K06211 http://www.genome.jp/dbget-bin/www_bget?KO:K06211 OMA TAIRQKG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TAIRQKG PROSITE PS50943 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50943 PSORT swissprot:NADR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NADR_ECOLI PSORT-B swissprot:NADR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NADR_ECOLI PSORT2 swissprot:NADR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NADR_ECOLI Pfam PF01381 http://pfam.xfam.org/family/PF01381 Phobius swissprot:NADR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NADR_ECOLI ProteinModelPortal P27278 http://www.proteinmodelportal.org/query/uniprot/P27278 PubMed 10464228 http://www.ncbi.nlm.nih.gov/pubmed/10464228 PubMed 1327967 http://www.ncbi.nlm.nih.gov/pubmed/1327967 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418807 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418807 RefSeq WP_000093814 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000093814 SMART SM00530 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00530 SMR P27278 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P27278 STRING 511145.b4390 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4390&targetmode=cogs STRING COG1056 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1056&targetmode=cogs STRING COG1396 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1396&targetmode=cogs STRING COG3172 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3172&targetmode=cogs SUPFAM SSF47413 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47413 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR00125 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00125 TIGRFAMs TIGR01526 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01526 UniProtKB NADR_ECOLI http://www.uniprot.org/uniprot/NADR_ECOLI UniProtKB-AC P27278 http://www.uniprot.org/uniprot/P27278 charge swissprot:NADR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NADR_ECOLI eggNOG COG1056 http://eggnogapi.embl.de/nog_data/html/tree/COG1056 eggNOG COG1396 http://eggnogapi.embl.de/nog_data/html/tree/COG1396 eggNOG COG3172 http://eggnogapi.embl.de/nog_data/html/tree/COG3172 eggNOG ENOG4107VZS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107VZS epestfind swissprot:NADR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NADR_ECOLI garnier swissprot:NADR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NADR_ECOLI helixturnhelix swissprot:NADR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NADR_ECOLI hmoment swissprot:NADR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NADR_ECOLI iep swissprot:NADR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NADR_ECOLI inforesidue swissprot:NADR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NADR_ECOLI octanol swissprot:NADR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NADR_ECOLI pepcoil swissprot:NADR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NADR_ECOLI pepdigest swissprot:NADR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NADR_ECOLI pepinfo swissprot:NADR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NADR_ECOLI pepnet swissprot:NADR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NADR_ECOLI pepstats swissprot:NADR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NADR_ECOLI pepwheel swissprot:NADR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NADR_ECOLI pepwindow swissprot:NADR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NADR_ECOLI sigcleave swissprot:NADR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NADR_ECOLI ## Database ID URL or Descriptions # BioGrid 4260001 55 # EcoGene EG13425 ybjD # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0000731 DNA synthesis involved in DNA repair; IBA:GO_Central. # GO_process GO:0006302 double-strand break repair; IBA:GO_Central. # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.300 -; 2. # IntAct P75828 6 # InterPro IPR006171 Toprim_domain # InterPro IPR022602 DUF2813 # InterPro IPR027417 P-loop_NTPase # Organism YBJD_ECOLI Escherichia coli (strain K12) # PATRIC 32116959 VBIEscCol129921_0905 # PIR D64826 D64826 # PROSITE PS50880 TOPRIM # Pfam PF11398 DUF2813 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBJD_ECOLI Uncharacterized protein YbjD # RefSeq NP_415397 NC_000913.3 # RefSeq WP_000599802 NZ_LN832404.1 # SIMILARITY Contains 1 Toprim domain. {ECO:0000255|PROSITE- ProRule PRU00995}. # SUPFAM SSF52540 SSF52540 # eggNOG COG3593 LUCA # eggNOG ENOG4105CPB Bacteria BLAST swissprot:YBJD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBJD_ECOLI BioCyc ECOL316407:JW0860-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0860-MONOMER BioCyc EcoCyc:G6459-MONOMER http://biocyc.org/getid?id=EcoCyc:G6459-MONOMER COG COG3593 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3593 DIP DIP-11446N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11446N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3199 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3199 EcoGene EG13425 http://www.ecogene.org/geneInfo.php?eg_id=EG13425 EnsemblBacteria AAC73963 http://www.ensemblgenomes.org/id/AAC73963 EnsemblBacteria AAC73963 http://www.ensemblgenomes.org/id/AAC73963 EnsemblBacteria BAA35594 http://www.ensemblgenomes.org/id/BAA35594 EnsemblBacteria BAA35594 http://www.ensemblgenomes.org/id/BAA35594 EnsemblBacteria BAA35594 http://www.ensemblgenomes.org/id/BAA35594 EnsemblBacteria b0876 http://www.ensemblgenomes.org/id/b0876 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0000731 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000731 GO_process GO:0006302 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006302 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945498 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945498 HOGENOM HOG000278298 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278298&db=HOGENOM6 InParanoid P75828 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75828 IntAct P75828 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75828* InterPro IPR006171 http://www.ebi.ac.uk/interpro/entry/IPR006171 InterPro IPR022602 http://www.ebi.ac.uk/interpro/entry/IPR022602 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Gene ecj:JW0860 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0860 KEGG_Gene eco:b0876 http://www.genome.jp/dbget-bin/www_bget?eco:b0876 KEGG_Orthology KO:K07459 http://www.genome.jp/dbget-bin/www_bget?KO:K07459 OMA MNMRRVI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MNMRRVI PROSITE PS50880 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50880 PSORT swissprot:YBJD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBJD_ECOLI PSORT-B swissprot:YBJD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBJD_ECOLI PSORT2 swissprot:YBJD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBJD_ECOLI Pfam PF11398 http://pfam.xfam.org/family/PF11398 Phobius swissprot:YBJD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBJD_ECOLI ProteinModelPortal P75828 http://www.proteinmodelportal.org/query/uniprot/P75828 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415397 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415397 RefSeq WP_000599802 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000599802 STRING 511145.b0876 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0876&targetmode=cogs STRING COG3593 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3593&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB YBJD_ECOLI http://www.uniprot.org/uniprot/YBJD_ECOLI UniProtKB-AC P75828 http://www.uniprot.org/uniprot/P75828 charge swissprot:YBJD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBJD_ECOLI eggNOG COG3593 http://eggnogapi.embl.de/nog_data/html/tree/COG3593 eggNOG ENOG4105CPB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CPB epestfind swissprot:YBJD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBJD_ECOLI garnier swissprot:YBJD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBJD_ECOLI helixturnhelix swissprot:YBJD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBJD_ECOLI hmoment swissprot:YBJD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBJD_ECOLI iep swissprot:YBJD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBJD_ECOLI inforesidue swissprot:YBJD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBJD_ECOLI octanol swissprot:YBJD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBJD_ECOLI pepcoil swissprot:YBJD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBJD_ECOLI pepdigest swissprot:YBJD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBJD_ECOLI pepinfo swissprot:YBJD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBJD_ECOLI pepnet swissprot:YBJD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBJD_ECOLI pepstats swissprot:YBJD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBJD_ECOLI pepwheel swissprot:YBJD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBJD_ECOLI pepwindow swissprot:YBJD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBJD_ECOLI sigcleave swissprot:YBJD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBJD_ECOLI ## Database ID URL or Descriptions # BioGrid 4261259 664 # CDD cd06257 DnaJ # EcoGene EG12193 cbpA # FUNCTION CBPA_ECOLI DNA-binding protein that preferentially recognizes a curved DNA sequence. It is probably a functional analog of DnaJ; displays overlapping activities with DnaJ, but functions under different conditions, probably acting as a molecular chaperone in an adaptive response to environmental stresses other than heat shock. Lacks autonomous chaperone activity; binds native substrates and targets them for recognition by DnaK. Its activity is inhibited by the binding of CbpM. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-HAMAP. # GO_component GO:0009295 nucleoid; IEA:UniProtKB-SubCell. # GO_function GO:0003681 bent DNA binding; IDA:EcoliWiki. # GO_process GO:0006457 protein folding; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006457 protein folding # Gene3D 1.10.287.110 -; 1. # HAMAP MF_01154 CbpA # INDUCTION In late stationary phase, by phosphate-starvation conditions. {ECO:0000269|PubMed 7997164}. # INTERACTION CBPA_ECOLI P0A6Y8 dnaK; NbExp=4; IntAct=EBI-546131, EBI-542092; # IntAct P36659 49 # InterPro IPR001623 DnaJ_domain # InterPro IPR002939 DnaJ_C # InterPro IPR008971 HSP40/DnaJ_pept-bd # InterPro IPR018253 DnaJ_domain_CS # InterPro IPR023859 DNA-bd_curved-DNA # KEGG_Brite ko03036 Chromosome # KEGG_Brite ko03110 Chaperones and folding catalysts # MISCELLANEOUS CBPA_ECOLI It binds to curved DNA in a sequence-nonspecific fashion. # Organism CBPA_ECOLI Escherichia coli (strain K12) # PATRIC 32117225 VBIEscCol129921_1036 # PDB 2KQX NMR; -; A=2-72 # PDB 3UCS X-ray; 1.87 A; C/D=2-73 # PIR F64841 F64841 # PRINTS PR00625 JDOMAIN # PROSITE PS00636 DNAJ_1 # PROSITE PS50076 DNAJ_2 # Pfam PF00226 DnaJ # Pfam PF01556 DnaJ_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CBPA_ECOLI Curved DNA-binding protein # RefSeq NP_415520 NC_000913.3 # RefSeq WP_000420621 NZ_LN832404.1 # SIMILARITY Contains 1 J domain. {ECO 0000305}. # SMART SM00271 DnaJ # SUBCELLULAR LOCATION CBPA_ECOLI Cytoplasm, nucleoid {ECO 0000269|PubMed 10947847, ECO 0000269|PubMed 8302830}. # SUPFAM SSF46565 SSF46565 # SUPFAM SSF49493 SSF49493; 2 # eggNOG COG2214 LUCA # eggNOG ENOG4105DVC Bacteria BLAST swissprot:CBPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CBPA_ECOLI BioCyc ECOL316407:JW0985-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0985-MONOMER BioCyc EcoCyc:EG12193-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12193-MONOMER COG COG2214 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2214 DIP DIP-9249N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9249N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2443.2000.00350.x http://dx.doi.org/10.1046/j.1365-2443.2000.00350.x DOI 10.1073/pnas.91.3.1054 http://dx.doi.org/10.1073/pnas.91.3.1054 DOI 10.1074/jbc.274.46.33105 http://dx.doi.org/10.1074/jbc.274.46.33105 DOI 10.1074/jbc.M404862200 http://dx.doi.org/10.1074/jbc.M404862200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1994.tb00442.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb00442.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01757-06 http://dx.doi.org/10.1128/JB.01757-06 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D16500 http://www.ebi.ac.uk/ena/data/view/D16500 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2110 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2110 EcoGene EG12193 http://www.ecogene.org/geneInfo.php?eg_id=EG12193 EnsemblBacteria AAC74085 http://www.ensemblgenomes.org/id/AAC74085 EnsemblBacteria AAC74085 http://www.ensemblgenomes.org/id/AAC74085 EnsemblBacteria BAA36142 http://www.ensemblgenomes.org/id/BAA36142 EnsemblBacteria BAA36142 http://www.ensemblgenomes.org/id/BAA36142 EnsemblBacteria BAA36142 http://www.ensemblgenomes.org/id/BAA36142 EnsemblBacteria b1000 http://www.ensemblgenomes.org/id/b1000 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0009295 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009295 GO_function GO:0003681 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003681 GO_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 Gene3D 1.10.287.110 http://www.cathdb.info/version/latest/superfamily/1.10.287.110 GeneID 947572 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947572 HAMAP MF_01154 http://hamap.expasy.org/unirule/MF_01154 HOGENOM HOG000226716 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000226716&db=HOGENOM6 InParanoid P36659 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P36659 IntAct P36659 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P36659* InterPro IPR001623 http://www.ebi.ac.uk/interpro/entry/IPR001623 InterPro IPR002939 http://www.ebi.ac.uk/interpro/entry/IPR002939 InterPro IPR008971 http://www.ebi.ac.uk/interpro/entry/IPR008971 InterPro IPR018253 http://www.ebi.ac.uk/interpro/entry/IPR018253 InterPro IPR023859 http://www.ebi.ac.uk/interpro/entry/IPR023859 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW0985 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0985 KEGG_Gene eco:b1000 http://www.genome.jp/dbget-bin/www_bget?eco:b1000 KEGG_Orthology KO:K05516 http://www.genome.jp/dbget-bin/www_bget?KO:K05516 MINT MINT-1219908 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1219908 OMA FGMVEQE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FGMVEQE PDB 2KQX http://www.ebi.ac.uk/pdbe-srv/view/entry/2KQX PDB 3UCS http://www.ebi.ac.uk/pdbe-srv/view/entry/3UCS PDBsum 2KQX http://www.ebi.ac.uk/pdbsum/2KQX PDBsum 3UCS http://www.ebi.ac.uk/pdbsum/3UCS PRINTS PR00625 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00625 PROSITE PS00636 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00636 PROSITE PS50076 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50076 PSORT swissprot:CBPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CBPA_ECOLI PSORT-B swissprot:CBPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CBPA_ECOLI PSORT2 swissprot:CBPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CBPA_ECOLI Pfam PF00226 http://pfam.xfam.org/family/PF00226 Pfam PF01556 http://pfam.xfam.org/family/PF01556 Phobius swissprot:CBPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CBPA_ECOLI PhylomeDB P36659 http://phylomedb.org/?seqid=P36659 ProteinModelPortal P36659 http://www.proteinmodelportal.org/query/uniprot/P36659 PubMed 10551881 http://www.ncbi.nlm.nih.gov/pubmed/10551881 PubMed 10947847 http://www.ncbi.nlm.nih.gov/pubmed/10947847 PubMed 15184371 http://www.ncbi.nlm.nih.gov/pubmed/15184371 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17337578 http://www.ncbi.nlm.nih.gov/pubmed/17337578 PubMed 7601860 http://www.ncbi.nlm.nih.gov/pubmed/7601860 PubMed 7997164 http://www.ncbi.nlm.nih.gov/pubmed/7997164 PubMed 8302830 http://www.ncbi.nlm.nih.gov/pubmed/8302830 PubMed 8824642 http://www.ncbi.nlm.nih.gov/pubmed/8824642 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415520 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415520 RefSeq WP_000420621 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000420621 SMART SM00271 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00271 SMR P36659 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P36659 STRING 511145.b1000 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1000&targetmode=cogs STRING COG2214 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2214&targetmode=cogs SUPFAM SSF46565 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46565 SUPFAM SSF49493 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49493 UniProtKB CBPA_ECOLI http://www.uniprot.org/uniprot/CBPA_ECOLI UniProtKB-AC P36659 http://www.uniprot.org/uniprot/P36659 charge swissprot:CBPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CBPA_ECOLI eggNOG COG2214 http://eggnogapi.embl.de/nog_data/html/tree/COG2214 eggNOG ENOG4105DVC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DVC epestfind swissprot:CBPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CBPA_ECOLI garnier swissprot:CBPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CBPA_ECOLI helixturnhelix swissprot:CBPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CBPA_ECOLI hmoment swissprot:CBPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CBPA_ECOLI iep swissprot:CBPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CBPA_ECOLI inforesidue swissprot:CBPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CBPA_ECOLI octanol swissprot:CBPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CBPA_ECOLI pepcoil swissprot:CBPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CBPA_ECOLI pepdigest swissprot:CBPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CBPA_ECOLI pepinfo swissprot:CBPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CBPA_ECOLI pepnet swissprot:CBPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CBPA_ECOLI pepstats swissprot:CBPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CBPA_ECOLI pepwheel swissprot:CBPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CBPA_ECOLI pepwindow swissprot:CBPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CBPA_ECOLI sigcleave swissprot:CBPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CBPA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262559 10 # EcoGene EG11187 yibA # GO_process GO:0006974 cellular response to DNA damage stimulus; IMP:EcoCyc. # GO_process GO:0046677 response to antibiotic; IMP:EcoCyc. # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # Gene3D 1.25.10.10 -; 1. # IntAct P0ADK6 10 # InterPro IPR011989 ARM-like # InterPro IPR016024 ARM-type_fold # Organism YIBA_ECOLI Escherichia coli (strain K12) # PATRIC 32122668 VBIEscCol129921_3711 # PDB 1OYZ X-ray; 2.10 A; A=1-280 # PIR S47815 S47815 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIBA_ECOLI Protein YibA # RefSeq NP_418051 NC_000913.3 # RefSeq WP_000072850 NZ_LN832404.1 # SUPFAM SSF48371 SSF48371 # eggNOG ENOG4105NUP Bacteria # eggNOG ENOG41127FW LUCA BLAST swissprot:YIBA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIBA_ECOLI BioCyc ECOL316407:JW3568-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3568-MONOMER BioCyc EcoCyc:EG11187-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11187-MONOMER DIP DIP-48203N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48203N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19044 http://www.ebi.ac.uk/ena/data/view/L19044 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1173 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1173 EcoGene EG11187 http://www.ecogene.org/geneInfo.php?eg_id=EG11187 EnsemblBacteria AAC76618 http://www.ensemblgenomes.org/id/AAC76618 EnsemblBacteria AAC76618 http://www.ensemblgenomes.org/id/AAC76618 EnsemblBacteria BAE77699 http://www.ensemblgenomes.org/id/BAE77699 EnsemblBacteria BAE77699 http://www.ensemblgenomes.org/id/BAE77699 EnsemblBacteria BAE77699 http://www.ensemblgenomes.org/id/BAE77699 EnsemblBacteria b3594 http://www.ensemblgenomes.org/id/b3594 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.25.10.10 http://www.cathdb.info/version/latest/superfamily/1.25.10.10 GeneID 948108 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948108 HOGENOM HOG000009633 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009633&db=HOGENOM6 InParanoid P0ADK6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADK6 IntAct P0ADK6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADK6* InterPro IPR011989 http://www.ebi.ac.uk/interpro/entry/IPR011989 InterPro IPR016024 http://www.ebi.ac.uk/interpro/entry/IPR016024 KEGG_Gene ecj:JW3568 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3568 KEGG_Gene eco:b3594 http://www.genome.jp/dbget-bin/www_bget?eco:b3594 MINT MINT-1263383 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1263383 OMA VKNWAAF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VKNWAAF PDB 1OYZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1OYZ PDBsum 1OYZ http://www.ebi.ac.uk/pdbsum/1OYZ PSORT swissprot:YIBA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIBA_ECOLI PSORT-B swissprot:YIBA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIBA_ECOLI PSORT2 swissprot:YIBA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIBA_ECOLI Phobius swissprot:YIBA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIBA_ECOLI ProteinModelPortal P0ADK6 http://www.proteinmodelportal.org/query/uniprot/P0ADK6 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2403547 http://www.ncbi.nlm.nih.gov/pubmed/2403547 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418051 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418051 RefSeq WP_000072850 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000072850 SMR P0ADK6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADK6 STRING 511145.b3594 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3594&targetmode=cogs SUPFAM SSF48371 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48371 UniProtKB YIBA_ECOLI http://www.uniprot.org/uniprot/YIBA_ECOLI UniProtKB-AC P0ADK6 http://www.uniprot.org/uniprot/P0ADK6 charge swissprot:YIBA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIBA_ECOLI eggNOG ENOG4105NUP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105NUP eggNOG ENOG41127FW http://eggnogapi.embl.de/nog_data/html/tree/ENOG41127FW epestfind swissprot:YIBA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIBA_ECOLI garnier swissprot:YIBA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIBA_ECOLI helixturnhelix swissprot:YIBA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIBA_ECOLI hmoment swissprot:YIBA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIBA_ECOLI iep swissprot:YIBA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIBA_ECOLI inforesidue swissprot:YIBA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIBA_ECOLI octanol swissprot:YIBA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIBA_ECOLI pepcoil swissprot:YIBA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIBA_ECOLI pepdigest swissprot:YIBA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIBA_ECOLI pepinfo swissprot:YIBA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIBA_ECOLI pepnet swissprot:YIBA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIBA_ECOLI pepstats swissprot:YIBA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIBA_ECOLI pepwheel swissprot:YIBA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIBA_ECOLI pepwindow swissprot:YIBA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIBA_ECOLI sigcleave swissprot:YIBA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIBA_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES IADA_ECOLI Kinetic parameters KM=0.81 mM for beta-aspartylleucine (at pH 8.0) {ECO 0000269|PubMed 4880759}; pH dependence Optimum pH is 7.5. Active over a wide pH range. {ECO 0000269|PubMed 4880759}; # BRENDA 3.4.19 2026 # BioGrid 4261005 9 # CDD cd01308 Isoaspartyl-dipeptidase # COFACTOR IADA_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 12718528, ECO 0000269|PubMed 12946361, ECO 0000269|PubMed 15882050}; Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000269|PubMed 12718528, ECO 0000269|PubMed 12946361, ECO 0000269|PubMed 15882050}; Note=Binds 2 Zn(2+) ions per subunit. Has highest activity with Zn(2+) ions, but is also active with Co(2+) ions. {ECO 0000269|PubMed 12718528, ECO 0000269|PubMed 12946361, ECO 0000269|PubMed 15882050}; # DISRUPTION PHENOTYPE No observable phenotype. Does not result in reduced stationary phase or heat shock survival. Approximately 31% of the enzyme activity present. {ECO:0000269|PubMed 7876157}. # ENZYME REGULATION P-hydroxymercuribenzoate causes a slight inhibition (8 to 17 %). Iodoacetamide, o-iodosobenzoate and ammonium persulfate do not inhibit the enzyme activity. {ECO:0000269|PubMed 4880759}. # EcoGene EG12567 iadA # FUNCTION IADA_ECOLI Catalyzes the hydrolytic cleavage of a subset of L- isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation. The best substrate for the enzyme reported thus far is iso-Asp-Leu. {ECO 0000269|PubMed 12718528, ECO 0000269|PubMed 15882050, ECO 0000269|PubMed 4880759, ECO 0000269|PubMed 7876157}. # GO_component GO:0005737 cytoplasm; IDA:UniProtKB. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008237 metallopeptidase activity; IEA:UniProtKB-KW. # GO_function GO:0008270 zinc ion binding; IDA:UniProtKB. # GO_function GO:0008798 beta-aspartyl-peptidase activity; IDA:UniProtKB. # GO_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; IEA:InterPro. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_function GO:0043167 ion binding # Gene3D 2.30.40.10 -; 1. # IntAct P39377 4 # InterPro IPR006680 Amidohydro-rel # InterPro IPR010229 Pept_M38_dipep # InterPro IPR011059 Metal-dep_hydrolase_composite # InterPro IPR032466 Metal_Hydrolase # InterPro IPR033826 Isoaspartyl-dipeptidase # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # Organism IADA_ECOLI Escherichia coli (strain K12) # PATRIC 32124258 VBIEscCol129921_4472 # PDB 1ONW X-ray; 1.65 A; A/B=1-390 # PDB 1ONX X-ray; 2.10 A; A/B=1-390 # PDB 1PO9 X-ray; 2.00 A; A/B=1-390 # PDB 1POJ X-ray; 3.30 A; A/B=1-390 # PDB 1POK X-ray; 2.70 A; A/B=1-390 # PDB 1YBQ X-ray; 2.00 A; A/B=1-390 # PDB 2AQO X-ray; 1.95 A; A/B=1-390 # PDB 2AQV X-ray; 1.95 A; A/B=1-390 # PIR B55889 B55889 # PIRSF PIRSF001238 IadA # PTM IADA_ECOLI Carbamylation allows a single lysine to coordinate two zinc ions (PubMed 12718528, PubMed 12946361, PubMed 15882050, PubMed 16289685). {ECO 0000269|PubMed 12718528, ECO 0000269|PubMed 12946361, ECO 0000269|PubMed 15882050, ECO 0000269|PubMed 16289685}. # Pfam PF01979 Amidohydro_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName IADA_ECOLI Isoaspartyl dipeptidase # RefSeq NP_418748 NC_000913.3 # RefSeq WP_000568432 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase M38 family. {ECO 0000305}. # SUBCELLULAR LOCATION IADA_ECOLI Cytoplasm {ECO 0000269|PubMed 7876157}. # SUPFAM SSF51338 SSF51338; 2 # SUPFAM SSF51556 SSF51556 # TIGRFAMs TIGR01975 isoAsp_dipep # eggNOG ENOG4105DYB Bacteria # eggNOG ENOG410XNTK LUCA BLAST swissprot:IADA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:IADA_ECOLI BioCyc ECOL316407:JW4291-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4291-MONOMER BioCyc EcoCyc:G7925-MONOMER http://biocyc.org/getid?id=EcoCyc:G7925-MONOMER BioCyc MetaCyc:G7925-MONOMER http://biocyc.org/getid?id=MetaCyc:G7925-MONOMER DIP DIP-10001N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10001N DOI 10.1016/S0022-2836(03)00845-3 http://dx.doi.org/10.1016/S0022-2836(03)00845-3 DOI 10.1016/j.bioorg.2005.10.002 http://dx.doi.org/10.1016/j.bioorg.2005.10.002 DOI 10.1021/bi034233p http://dx.doi.org/10.1021/bi034233p DOI 10.1021/bi050008r http://dx.doi.org/10.1021/bi050008r DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.270.8.4076 http://dx.doi.org/10.1074/jbc.270.8.4076 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.19.- http://www.genome.jp/dbget-bin/www_bget?EC:3.4.19.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL U15029 http://www.ebi.ac.uk/ena/data/view/U15029 ENZYME 3.4.19.- http://enzyme.expasy.org/EC/3.4.19.- EchoBASE EB2455 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2455 EcoGene EG12567 http://www.ecogene.org/geneInfo.php?eg_id=EG12567 EnsemblBacteria AAC77284 http://www.ensemblgenomes.org/id/AAC77284 EnsemblBacteria AAC77284 http://www.ensemblgenomes.org/id/AAC77284 EnsemblBacteria BAE78321 http://www.ensemblgenomes.org/id/BAE78321 EnsemblBacteria BAE78321 http://www.ensemblgenomes.org/id/BAE78321 EnsemblBacteria BAE78321 http://www.ensemblgenomes.org/id/BAE78321 EnsemblBacteria b4328 http://www.ensemblgenomes.org/id/b4328 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008237 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008237 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0008798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008798 GO_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 2.30.40.10 http://www.cathdb.info/version/latest/superfamily/2.30.40.10 GeneID 948853 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948853 HOGENOM HOG000275891 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275891&db=HOGENOM6 InParanoid P39377 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39377 IntAct P39377 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39377* IntEnz 3.4.19 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.19 InterPro IPR006680 http://www.ebi.ac.uk/interpro/entry/IPR006680 InterPro IPR010229 http://www.ebi.ac.uk/interpro/entry/IPR010229 InterPro IPR011059 http://www.ebi.ac.uk/interpro/entry/IPR011059 InterPro IPR032466 http://www.ebi.ac.uk/interpro/entry/IPR032466 InterPro IPR033826 http://www.ebi.ac.uk/interpro/entry/IPR033826 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW4291 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4291 KEGG_Gene eco:b4328 http://www.genome.jp/dbget-bin/www_bget?eco:b4328 KEGG_Orthology KO:K01305 http://www.genome.jp/dbget-bin/www_bget?KO:K01305 OMA PTHINRN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PTHINRN PDB 1ONW http://www.ebi.ac.uk/pdbe-srv/view/entry/1ONW PDB 1ONX http://www.ebi.ac.uk/pdbe-srv/view/entry/1ONX PDB 1PO9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1PO9 PDB 1POJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1POJ PDB 1POK http://www.ebi.ac.uk/pdbe-srv/view/entry/1POK PDB 1YBQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1YBQ PDB 2AQO http://www.ebi.ac.uk/pdbe-srv/view/entry/2AQO PDB 2AQV http://www.ebi.ac.uk/pdbe-srv/view/entry/2AQV PDBsum 1ONW http://www.ebi.ac.uk/pdbsum/1ONW PDBsum 1ONX http://www.ebi.ac.uk/pdbsum/1ONX PDBsum 1PO9 http://www.ebi.ac.uk/pdbsum/1PO9 PDBsum 1POJ http://www.ebi.ac.uk/pdbsum/1POJ PDBsum 1POK http://www.ebi.ac.uk/pdbsum/1POK PDBsum 1YBQ http://www.ebi.ac.uk/pdbsum/1YBQ PDBsum 2AQO http://www.ebi.ac.uk/pdbsum/2AQO PDBsum 2AQV http://www.ebi.ac.uk/pdbsum/2AQV PSORT swissprot:IADA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:IADA_ECOLI PSORT-B swissprot:IADA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:IADA_ECOLI PSORT2 swissprot:IADA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:IADA_ECOLI Pfam PF01979 http://pfam.xfam.org/family/PF01979 Phobius swissprot:IADA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:IADA_ECOLI PhylomeDB P39377 http://phylomedb.org/?seqid=P39377 ProteinModelPortal P39377 http://www.proteinmodelportal.org/query/uniprot/P39377 PubMed 12718528 http://www.ncbi.nlm.nih.gov/pubmed/12718528 PubMed 12946361 http://www.ncbi.nlm.nih.gov/pubmed/12946361 PubMed 15882050 http://www.ncbi.nlm.nih.gov/pubmed/15882050 PubMed 16289685 http://www.ncbi.nlm.nih.gov/pubmed/16289685 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 4880759 http://www.ncbi.nlm.nih.gov/pubmed/4880759 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 7876157 http://www.ncbi.nlm.nih.gov/pubmed/7876157 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418748 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418748 RefSeq WP_000568432 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000568432 SMR P39377 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39377 STRING 511145.b4328 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4328&targetmode=cogs SUPFAM SSF51338 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51338 SUPFAM SSF51556 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51556 TIGRFAMs TIGR01975 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01975 UniProtKB IADA_ECOLI http://www.uniprot.org/uniprot/IADA_ECOLI UniProtKB-AC P39377 http://www.uniprot.org/uniprot/P39377 charge swissprot:IADA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:IADA_ECOLI eggNOG ENOG4105DYB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DYB eggNOG ENOG410XNTK http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNTK epestfind swissprot:IADA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:IADA_ECOLI garnier swissprot:IADA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:IADA_ECOLI helixturnhelix swissprot:IADA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:IADA_ECOLI hmoment swissprot:IADA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:IADA_ECOLI iep swissprot:IADA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:IADA_ECOLI inforesidue swissprot:IADA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:IADA_ECOLI octanol swissprot:IADA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:IADA_ECOLI pepcoil swissprot:IADA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:IADA_ECOLI pepdigest swissprot:IADA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:IADA_ECOLI pepinfo swissprot:IADA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:IADA_ECOLI pepnet swissprot:IADA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:IADA_ECOLI pepstats swissprot:IADA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:IADA_ECOLI pepwheel swissprot:IADA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:IADA_ECOLI pepwindow swissprot:IADA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:IADA_ECOLI sigcleave swissprot:IADA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:IADA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260961 99 # EcoGene EG13786 ddpF # FUNCTION DDPF_ECOLI Part of the ABC transporter complex DdpABCDF, which is probably involved in D,D-dipeptide transport. Probably responsible for energy coupling to the transport system. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016887 ATPase activity; IEA:InterPro. # GO_process GO:0015031 protein transport; IEA:UniProtKB-KW. # GO_process GO:0015833 peptide transport; IEA:UniProtKB-KW. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # Gene3D 3.40.50.300 -; 1. # INDUCTION Induced by RpoS in stationary phase. {ECO:0000269|PubMed 9751644}. # IntAct P77622 2 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR013563 Oligopep_ABC_C # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00239 Peptides/nickel transport system # KEGG_Brite ko02000 Transporters # Organism DDPF_ECOLI Escherichia coli (strain K12) # PATRIC 32118260 VBIEscCol129921_1550 # PIR F64901 F64901 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # Pfam PF00005 ABC_tran # Pfam PF08352 oligo_HPY # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DDPF_ECOLI Probable D,D-dipeptide transport ATP-binding protein DdpF # RefSeq NP_416000 NC_000913.3 # RefSeq WP_001285536 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA # SUBCELLULAR LOCATION DDPF_ECOLI Cell inner membrane {ECO 0000305}; Peripheral membrane protein {ECO 0000305}. # SUBUNIT The complex is composed of two ATP-binding proteins (DdpD and DdpF), two transmembrane proteins (DdpB and DdpC) and a solute-binding protein (DdpA). {ECO 0000305}. # SUPFAM SSF52540 SSF52540 # TCDB 3.A.1.5.38 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR01727 oligo_HPY # eggNOG COG1124 LUCA # eggNOG ENOG4107H6U Bacteria BLAST swissprot:DDPF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DDPF_ECOLI BioCyc ECOL316407:JW1478-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1478-MONOMER BioCyc EcoCyc:YDDO-MONOMER http://biocyc.org/getid?id=EcoCyc:YDDO-MONOMER COG COG1123 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1123 COG COG1124 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1124 DOI 10.1016/S1074-5521(98)90005-9 http://dx.doi.org/10.1016/S1074-5521(98)90005-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.96.20.11028 http://dx.doi.org/10.1073/pnas.96.20.11028 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3547 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3547 EcoGene EG13786 http://www.ecogene.org/geneInfo.php?eg_id=EG13786 EnsemblBacteria AAC74556 http://www.ensemblgenomes.org/id/AAC74556 EnsemblBacteria AAC74556 http://www.ensemblgenomes.org/id/AAC74556 EnsemblBacteria BAA15138 http://www.ensemblgenomes.org/id/BAA15138 EnsemblBacteria BAA15138 http://www.ensemblgenomes.org/id/BAA15138 EnsemblBacteria BAA15138 http://www.ensemblgenomes.org/id/BAA15138 EnsemblBacteria b1483 http://www.ensemblgenomes.org/id/b1483 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_process GO:0015031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031 GO_process GO:0015833 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015833 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 946020 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946020 InParanoid P77622 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77622 IntAct P77622 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77622* InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR013563 http://www.ebi.ac.uk/interpro/entry/IPR013563 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1478 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1478 KEGG_Gene eco:b1483 http://www.genome.jp/dbget-bin/www_bget?eco:b1483 KEGG_Orthology KO:K02032 http://www.genome.jp/dbget-bin/www_bget?KO:K02032 OMA IPMHEEN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IPMHEEN PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:DDPF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DDPF_ECOLI PSORT-B swissprot:DDPF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DDPF_ECOLI PSORT2 swissprot:DDPF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DDPF_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Pfam PF08352 http://pfam.xfam.org/family/PF08352 Phobius swissprot:DDPF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DDPF_ECOLI PhylomeDB P77622 http://phylomedb.org/?seqid=P77622 ProteinModelPortal P77622 http://www.proteinmodelportal.org/query/uniprot/P77622 PubMed 10500118 http://www.ncbi.nlm.nih.gov/pubmed/10500118 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9751644 http://www.ncbi.nlm.nih.gov/pubmed/9751644 RefSeq NP_416000 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416000 RefSeq WP_001285536 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001285536 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P77622 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77622 STRING 511145.b1483 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1483&targetmode=cogs STRING COG1123 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1123&targetmode=cogs STRING COG1124 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1124&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.5.38 http://www.tcdb.org/search/result.php?tc=3.A.1.5.38 TIGRFAMs TIGR01727 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01727 UniProtKB DDPF_ECOLI http://www.uniprot.org/uniprot/DDPF_ECOLI UniProtKB-AC P77622 http://www.uniprot.org/uniprot/P77622 charge swissprot:DDPF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DDPF_ECOLI eggNOG COG1124 http://eggnogapi.embl.de/nog_data/html/tree/COG1124 eggNOG ENOG4107H6U http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107H6U epestfind swissprot:DDPF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DDPF_ECOLI garnier swissprot:DDPF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DDPF_ECOLI helixturnhelix swissprot:DDPF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DDPF_ECOLI hmoment swissprot:DDPF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DDPF_ECOLI iep swissprot:DDPF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DDPF_ECOLI inforesidue swissprot:DDPF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DDPF_ECOLI octanol swissprot:DDPF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DDPF_ECOLI pepcoil swissprot:DDPF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DDPF_ECOLI pepdigest swissprot:DDPF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DDPF_ECOLI pepinfo swissprot:DDPF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DDPF_ECOLI pepnet swissprot:DDPF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DDPF_ECOLI pepstats swissprot:DDPF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DDPF_ECOLI pepwheel swissprot:DDPF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DDPF_ECOLI pepwindow swissprot:DDPF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DDPF_ECOLI sigcleave swissprot:DDPF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DDPF_ECOLI ## Database ID URL or Descriptions # BioGrid 4262851 13 # EcoGene EG14250 ymfL # Organism YMFL_ECOLI Escherichia coli (strain K12) # PATRIC 32117533 VBIEscCol129921_1189 # PIR H64859 H64859 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YMFL_ECOLI Uncharacterized protein YmfL # RefSeq NP_415665 NC_000913.3 # RefSeq WP_000515837 NZ_CP010440.1 # SEQUENCE CAUTION Sequence=BAA35973.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # eggNOG ENOG4108S1U Bacteria # eggNOG ENOG4111I1P LUCA BLAST swissprot:YMFL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YMFL_ECOLI BioCyc ECOL316407:JW1133-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1133-MONOMER BioCyc EcoCyc:G6591-MONOMER http://biocyc.org/getid?id=EcoCyc:G6591-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3998 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3998 EcoGene EG14250 http://www.ecogene.org/geneInfo.php?eg_id=EG14250 EnsemblBacteria AAC74231 http://www.ensemblgenomes.org/id/AAC74231 EnsemblBacteria AAC74231 http://www.ensemblgenomes.org/id/AAC74231 EnsemblBacteria BAA35973 http://www.ensemblgenomes.org/id/BAA35973 EnsemblBacteria BAA35973 http://www.ensemblgenomes.org/id/BAA35973 EnsemblBacteria BAA35973 http://www.ensemblgenomes.org/id/BAA35973 EnsemblBacteria b1147 http://www.ensemblgenomes.org/id/b1147 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945717 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945717 HOGENOM HOG000123881 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000123881&db=HOGENOM6 InParanoid P75976 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75976 KEGG_Gene ecj:JW1133 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1133 KEGG_Gene eco:b1147 http://www.genome.jp/dbget-bin/www_bget?eco:b1147 OMA KSINRNH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KSINRNH PSORT swissprot:YMFL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YMFL_ECOLI PSORT-B swissprot:YMFL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YMFL_ECOLI PSORT2 swissprot:YMFL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YMFL_ECOLI Phobius swissprot:YMFL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YMFL_ECOLI ProteinModelPortal P75976 http://www.proteinmodelportal.org/query/uniprot/P75976 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415665 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415665 RefSeq WP_000515837 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000515837 SMR P75976 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75976 STRING 511145.b1147 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1147&targetmode=cogs UniProtKB YMFL_ECOLI http://www.uniprot.org/uniprot/YMFL_ECOLI UniProtKB-AC P75976 http://www.uniprot.org/uniprot/P75976 charge swissprot:YMFL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YMFL_ECOLI eggNOG ENOG4108S1U http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108S1U eggNOG ENOG4111I1P http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111I1P epestfind swissprot:YMFL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YMFL_ECOLI garnier swissprot:YMFL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YMFL_ECOLI helixturnhelix swissprot:YMFL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YMFL_ECOLI hmoment swissprot:YMFL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YMFL_ECOLI iep swissprot:YMFL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YMFL_ECOLI inforesidue swissprot:YMFL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YMFL_ECOLI octanol swissprot:YMFL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YMFL_ECOLI pepcoil swissprot:YMFL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YMFL_ECOLI pepdigest swissprot:YMFL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YMFL_ECOLI pepinfo swissprot:YMFL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YMFL_ECOLI pepnet swissprot:YMFL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YMFL_ECOLI pepstats swissprot:YMFL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YMFL_ECOLI pepwheel swissprot:YMFL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YMFL_ECOLI pepwindow swissprot:YMFL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YMFL_ECOLI sigcleave swissprot:YMFL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YMFL_ECOLI ## Database ID URL or Descriptions # BioGrid 4261810 11 # CAUTION Could be the product of a pseudogene. The sequence shown here is interrupted by a IS2A insertion sequence. {ECO 0000305}. # EcoGene EG14236 yaiX # GO_function GO:0016746 transferase activity, transferring acyl groups; IEA:UniProtKB-KW. # GOslim_function GO:0016746 transferase activity, transferring acyl groups # IntAct P75697 2 # InterPro IPR001451 Hexapep # InterPro IPR011004 Trimer_LpxA-like # Organism YAIX_ECOLI Escherichia coli (strain K12) # PIR B64764 B64764 # PIR G64763 G64763 # Pfam PF00132 Hexapep; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAIX_ECOLI Putative uncharacterized acetyltransferase YaiX # SIMILARITY Belongs to the transferase hexapeptide repeat family. {ECO 0000305}. # SUPFAM SSF51161 SSF51161 BLAST swissprot:YAIX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAIX_ECOLI BioCyc ECOL316407:JW5814-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5814-MONOMER BioCyc EcoCyc:G6211-MONOMER http://biocyc.org/getid?id=EcoCyc:G6211-MONOMER BioCyc EcoCyc:G6214-MONOMER http://biocyc.org/getid?id=EcoCyc:G6214-MONOMER DIP DIP-28093N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-28093N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.3.1.- http://enzyme.expasy.org/EC/2.3.1.- EcoGene EG14236 http://www.ecogene.org/geneInfo.php?eg_id=EG14236 EnsemblBacteria BAE76143 http://www.ensemblgenomes.org/id/BAE76143 EnsemblBacteria BAE76143 http://www.ensemblgenomes.org/id/BAE76143 EnsemblBacteria BAE76143 http://www.ensemblgenomes.org/id/BAE76143 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 InParanoid P75697 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75697 IntAct P75697 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75697* IntEnz 2.3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1 InterPro IPR001451 http://www.ebi.ac.uk/interpro/entry/IPR001451 InterPro IPR011004 http://www.ebi.ac.uk/interpro/entry/IPR011004 KEGG_Gene ecj:JW5814 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5814 PSORT swissprot:YAIX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAIX_ECOLI PSORT-B swissprot:YAIX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAIX_ECOLI PSORT2 swissprot:YAIX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAIX_ECOLI Pfam PF00132 http://pfam.xfam.org/family/PF00132 Phobius swissprot:YAIX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAIX_ECOLI PhylomeDB P75697 http://phylomedb.org/?seqid=P75697 ProteinModelPortal P75697 http://www.proteinmodelportal.org/query/uniprot/P75697 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SMR P75697 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75697 STRING 316407.85674503 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85674503&targetmode=cogs SUPFAM SSF51161 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51161 UniProtKB YAIX_ECOLI http://www.uniprot.org/uniprot/YAIX_ECOLI UniProtKB-AC P75697 http://www.uniprot.org/uniprot/P75697 charge swissprot:YAIX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAIX_ECOLI epestfind swissprot:YAIX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAIX_ECOLI garnier swissprot:YAIX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAIX_ECOLI helixturnhelix swissprot:YAIX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAIX_ECOLI hmoment swissprot:YAIX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAIX_ECOLI iep swissprot:YAIX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAIX_ECOLI inforesidue swissprot:YAIX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAIX_ECOLI octanol swissprot:YAIX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAIX_ECOLI pepcoil swissprot:YAIX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAIX_ECOLI pepdigest swissprot:YAIX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAIX_ECOLI pepinfo swissprot:YAIX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAIX_ECOLI pepnet swissprot:YAIX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAIX_ECOLI pepstats swissprot:YAIX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAIX_ECOLI pepwheel swissprot:YAIX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAIX_ECOLI pepwindow swissprot:YAIX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAIX_ECOLI sigcleave swissprot:YAIX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAIX_ECOLI ## Database ID URL or Descriptions # AltName PAND_ECOLI Aspartate alpha-decarboxylase # AltName PAND_ECOLI Aspartate alpha-decarboxylase # BRENDA 4.1.1.11 2026 # BioGrid 4259730 203 # CATALYTIC ACTIVITY L-aspartate = beta-alanine + CO(2). {ECO:0000269|PubMed 6767707}. # CDD cd06919 Asp_decarbox # COFACTOR Name=pyruvate; Xref=ChEBI:CHEBI 15361; Note=Binds 1 pyruvoyl group covalently per subunit.; # ENZYME REGULATION PAND_ECOLI Inhibited by hydroxylamine, sodium borohydride, D-cycloserine, hydrazine, semicarbazine and succinic dehydrazine (PubMed 6767707). D-serine is a competitive inhibitor (PubMed 6767707). Cleavage and activation of PanD is accelerated by PanM (PubMed 23170229). {ECO 0000269|PubMed 23170229, ECO 0000269|PubMed 6767707}. # EcoGene EG11747 panD # FUNCTION PAND_ECOLI Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. {ECO 0000269|PubMed 6767707}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004068 aspartate 1-decarboxylase activity; IEA:UniProtKB-HAMAP. # GO_process GO:0006523 alanine biosynthetic process; IEA:InterPro. # GO_process GO:0015940 pantothenate biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0016540 protein autoprocessing; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # GOslim_process GO:0051604 protein maturation # HAMAP MF_00446 PanD # IntAct P0A790 2 # InterPro IPR003190 Asp_decarbox # InterPro IPR009010 Asp_de-COase-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00410 beta-Alanine metabolism # KEGG_Pathway ko00770 Pantothenate and CoA biosynthesis # Organism PAND_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21012 PTHR21012 # PATHWAY Cofactor biosynthesis; (R)-pantothenate biosynthesis; beta-alanine from L-aspartate step 1/1. # PATRIC 32115365 VBIEscCol129921_0134 # PDB 1AW8 X-ray; 2.20 A; A/D=1-24, B/E=25-115 # PDB 1PPY X-ray; 1.95 A; A/B=1-126 # PDB 1PQE X-ray; 1.95 A; A=1-126 # PDB 1PQF X-ray; 2.00 A; A/B=1-126 # PDB 1PQH X-ray; 1.29 A; A/B=1-126 # PDB 1PT0 X-ray; 2.00 A; A/B=1-126 # PDB 1PT1 X-ray; 1.90 A; A/B=1-126 # PDB 1PYQ X-ray; 1.90 A; A/B=1-126 # PDB 1PYU X-ray; 1.90 A; A/C=1-24, B/D=25-126 # PDB 3TM7 X-ray; 1.70 A; A/C=1-24, B/D=25-126 # PDB 4AOK X-ray; 1.50 A; A/D=1-24, B/E=26-126 # PDB 4AON X-ray; 1.50 A; A/D=1-24, B/E=25-126 # PDB 4AZD X-ray; 1.62 A; A/B=1-126 # PDB 4CRY X-ray; 1.61 A; A=1-24, G=25-126 # PDB 4CRZ X-ray; 1.70 A; A=1-126 # PDB 4CS0 X-ray; 2.10 A; A=1-126 # PDB 4D7Z X-ray; 1.90 A; A=1-24, B=26-119 # PIR C64736 C64736 # PIRSF PIRSF006246 Asp_decarbox # PTM PAND_ECOLI Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha- subunit with a pyruvoyl group at its N-terminus. # Pfam PF02261 Asp_decarbox # ProDom PD009294 Asp_decarbox # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PAND_ECOLI Aspartate 1-decarboxylase # RecName PAND_ECOLI Aspartate 1-decarboxylase alpha chain # RecName PAND_ECOLI Aspartate 1-decarboxylase beta chain # RecName PAND_ECOLI Aspartate 1-decarboxylase beta chain # RefSeq NP_414673 NC_000913.3 # RefSeq WP_000621515 NZ_LN832404.1 # SIMILARITY Belongs to the PanD family. {ECO 0000305}. # SUBCELLULAR LOCATION PAND_ECOLI Cytoplasm {ECO 0000269|PubMed 6767707}. # SUBUNIT PAND_ECOLI Heterooctamer of four alpha and four beta subunits (PubMed 9546220). Interacts with PanM (PubMed 23170229). {ECO 0000269|PubMed 23170229, ECO 0000269|PubMed 9546220}. # SUPFAM SSF50692 SSF50692 # TIGRFAMs TIGR00223 panD # UniPathway UPA00028 UER00002 # eggNOG COG0853 LUCA # eggNOG ENOG4108Z2X Bacteria BLAST swissprot:PAND_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PAND_ECOLI BioCyc ECOL316407:JW0127-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0127-MONOMER BioCyc EcoCyc:ASPDECARBOX-MONOMER http://biocyc.org/getid?id=EcoCyc:ASPDECARBOX-MONOMER BioCyc MetaCyc:ASPDECARBOX-MONOMER http://biocyc.org/getid?id=MetaCyc:ASPDECARBOX-MONOMER COG COG0853 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0853 DOI 10.1002/mbo3.34 http://dx.doi.org/10.1002/mbo3.34 DOI 10.1016/0378-1097(96)00321-7 http://dx.doi.org/10.1016/0378-1097(96)00321-7 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb0498-289 http://dx.doi.org/10.1038/nsb0498-289 DOI 10.1039/b106090m http://dx.doi.org/10.1039/b106090m DOI 10.1042/bj3230661 http://dx.doi.org/10.1042/bj3230661 DOI 10.1093/emboj/cdg575 http://dx.doi.org/10.1093/emboj/cdg575 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.1.1.11 http://www.genome.jp/dbget-bin/www_bget?EC:4.1.1.11 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L17086 http://www.ebi.ac.uk/ena/data/view/L17086 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 4.1.1.11 http://enzyme.expasy.org/EC/4.1.1.11 EchoBASE EB1697 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1697 EcoGene EG11747 http://www.ecogene.org/geneInfo.php?eg_id=EG11747 EnsemblBacteria AAC73242 http://www.ensemblgenomes.org/id/AAC73242 EnsemblBacteria AAC73242 http://www.ensemblgenomes.org/id/AAC73242 EnsemblBacteria BAB96708 http://www.ensemblgenomes.org/id/BAB96708 EnsemblBacteria BAB96708 http://www.ensemblgenomes.org/id/BAB96708 EnsemblBacteria BAB96708 http://www.ensemblgenomes.org/id/BAB96708 EnsemblBacteria b0131 http://www.ensemblgenomes.org/id/b0131 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004068 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004068 GO_process GO:0006523 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006523 GO_process GO:0015940 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015940 GO_process GO:0016540 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016540 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GOslim_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 GeneID 945686 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945686 HAMAP MF_00446 http://hamap.expasy.org/unirule/MF_00446 HOGENOM HOG000221007 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000221007&db=HOGENOM6 InParanoid P0A790 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A790 IntAct P0A790 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A790* IntEnz 4.1.1.11 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.1.11 InterPro IPR003190 http://www.ebi.ac.uk/interpro/entry/IPR003190 InterPro IPR009010 http://www.ebi.ac.uk/interpro/entry/IPR009010 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0127 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0127 KEGG_Gene eco:b0131 http://www.genome.jp/dbget-bin/www_bget?eco:b0131 KEGG_Orthology KO:K01579 http://www.genome.jp/dbget-bin/www_bget?KO:K01579 KEGG_Pathway ko00410 http://www.genome.jp/kegg-bin/show_pathway?ko00410 KEGG_Pathway ko00770 http://www.genome.jp/kegg-bin/show_pathway?ko00770 KEGG_Reaction rn:R00489 http://www.genome.jp/dbget-bin/www_bget?rn:R00489 OMA LYSKIHR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LYSKIHR PANTHER PTHR21012 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21012 PDB 1AW8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1AW8 PDB 1PPY http://www.ebi.ac.uk/pdbe-srv/view/entry/1PPY PDB 1PQE http://www.ebi.ac.uk/pdbe-srv/view/entry/1PQE PDB 1PQF http://www.ebi.ac.uk/pdbe-srv/view/entry/1PQF PDB 1PQH http://www.ebi.ac.uk/pdbe-srv/view/entry/1PQH PDB 1PT0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1PT0 PDB 1PT1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1PT1 PDB 1PYQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1PYQ PDB 1PYU http://www.ebi.ac.uk/pdbe-srv/view/entry/1PYU PDB 3TM7 http://www.ebi.ac.uk/pdbe-srv/view/entry/3TM7 PDB 4AOK http://www.ebi.ac.uk/pdbe-srv/view/entry/4AOK PDB 4AON http://www.ebi.ac.uk/pdbe-srv/view/entry/4AON PDB 4AZD http://www.ebi.ac.uk/pdbe-srv/view/entry/4AZD PDB 4CRY http://www.ebi.ac.uk/pdbe-srv/view/entry/4CRY PDB 4CRZ http://www.ebi.ac.uk/pdbe-srv/view/entry/4CRZ PDB 4CS0 http://www.ebi.ac.uk/pdbe-srv/view/entry/4CS0 PDB 4D7Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4D7Z PDBsum 1AW8 http://www.ebi.ac.uk/pdbsum/1AW8 PDBsum 1PPY http://www.ebi.ac.uk/pdbsum/1PPY PDBsum 1PQE http://www.ebi.ac.uk/pdbsum/1PQE PDBsum 1PQF http://www.ebi.ac.uk/pdbsum/1PQF PDBsum 1PQH http://www.ebi.ac.uk/pdbsum/1PQH PDBsum 1PT0 http://www.ebi.ac.uk/pdbsum/1PT0 PDBsum 1PT1 http://www.ebi.ac.uk/pdbsum/1PT1 PDBsum 1PYQ http://www.ebi.ac.uk/pdbsum/1PYQ PDBsum 1PYU http://www.ebi.ac.uk/pdbsum/1PYU PDBsum 3TM7 http://www.ebi.ac.uk/pdbsum/3TM7 PDBsum 4AOK http://www.ebi.ac.uk/pdbsum/4AOK PDBsum 4AON http://www.ebi.ac.uk/pdbsum/4AON PDBsum 4AZD http://www.ebi.ac.uk/pdbsum/4AZD PDBsum 4CRY http://www.ebi.ac.uk/pdbsum/4CRY PDBsum 4CRZ http://www.ebi.ac.uk/pdbsum/4CRZ PDBsum 4CS0 http://www.ebi.ac.uk/pdbsum/4CS0 PDBsum 4D7Z http://www.ebi.ac.uk/pdbsum/4D7Z PSORT swissprot:PAND_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PAND_ECOLI PSORT-B swissprot:PAND_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PAND_ECOLI PSORT2 swissprot:PAND_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PAND_ECOLI Pfam PF02261 http://pfam.xfam.org/family/PF02261 Phobius swissprot:PAND_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PAND_ECOLI ProteinModelPortal P0A790 http://www.proteinmodelportal.org/query/uniprot/P0A790 PubMed 12240302 http://www.ncbi.nlm.nih.gov/pubmed/12240302 PubMed 14633979 http://www.ncbi.nlm.nih.gov/pubmed/14633979 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 23170229 http://www.ncbi.nlm.nih.gov/pubmed/23170229 PubMed 6767707 http://www.ncbi.nlm.nih.gov/pubmed/6767707 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 8837478 http://www.ncbi.nlm.nih.gov/pubmed/8837478 PubMed 9169598 http://www.ncbi.nlm.nih.gov/pubmed/9169598 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9546220 http://www.ncbi.nlm.nih.gov/pubmed/9546220 RefSeq NP_414673 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414673 RefSeq WP_000621515 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000621515 SMR P0A790 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A790 STRING 511145.b0131 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0131&targetmode=cogs STRING COG0853 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0853&targetmode=cogs SUPFAM SSF50692 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50692 TIGRFAMs TIGR00223 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00223 UniProtKB PAND_ECOLI http://www.uniprot.org/uniprot/PAND_ECOLI UniProtKB-AC P0A790 http://www.uniprot.org/uniprot/P0A790 charge swissprot:PAND_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PAND_ECOLI eggNOG COG0853 http://eggnogapi.embl.de/nog_data/html/tree/COG0853 eggNOG ENOG4108Z2X http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Z2X epestfind swissprot:PAND_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PAND_ECOLI garnier swissprot:PAND_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PAND_ECOLI helixturnhelix swissprot:PAND_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PAND_ECOLI hmoment swissprot:PAND_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PAND_ECOLI iep swissprot:PAND_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PAND_ECOLI inforesidue swissprot:PAND_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PAND_ECOLI octanol swissprot:PAND_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PAND_ECOLI pepcoil swissprot:PAND_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PAND_ECOLI pepdigest swissprot:PAND_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PAND_ECOLI pepinfo swissprot:PAND_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PAND_ECOLI pepnet swissprot:PAND_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PAND_ECOLI pepstats swissprot:PAND_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PAND_ECOLI pepwheel swissprot:PAND_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PAND_ECOLI pepwindow swissprot:PAND_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PAND_ECOLI sigcleave swissprot:PAND_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PAND_ECOLI ## Database ID URL or Descriptions # BioGrid 4263534 149 # DISRUPTION PHENOTYPE No visible phenotype under standard growth conditions. Delays Lon protease-dependent lethality upon overexpression of Lon, but does not fully suppress it. {ECO:0000269|PubMed 15009896}. # EcoGene EG12844 yefM # FUNCTION YEFM_ECOLI Antitoxin component of a toxin-antitoxin (TA) module. Antitoxin that counteracts the effect of the YoeB toxin. YefM binds to the promoter region of the yefM-yeoB operon to repress transcription, YeoB acts as a corepressor. {ECO 0000269|PubMed 14672926, ECO 0000269|PubMed 15009896, ECO 0000269|PubMed 17170003, ECO 0000269|PubMed 19028895}. # GO_function GO:0015643 toxic substance binding; IDA:UniProtKB. # GO_function GO:0043565 sequence-specific DNA binding; IDA:UniProtKB. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0044010 single-species biofilm formation; IMP:EcoCyc. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IDA:UniProtKB. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.1620.10 -; 1. # INDUCTION YEFM_ECOLI Represses its own promoter; more strongly repressed by the YefM(2)YoeB heterotrimer. Induced in persister cells. Ectopic expression of Salmonella or Shigella toxin VapC induces the yefM- yoeB operon and also induces Yoeb toxin activity in a Lon protease-dependent manner. {ECO 0000269|PubMed 16768798, ECO 0000269|PubMed 17170003, ECO 0000269|PubMed 19400780}. # InterPro IPR006442 Antitoxin_Phd/YefM # MISCELLANEOUS YEFM_ECOLI Has been described as natively unfolded and proteolytically unstable in vivo (PubMed 14672926), but also as structured following overexpression in vitro (PubMed 17170003). Has a half-life of approximately 1 hour in vivo. {ECO 0000305|PubMed 14672926, ECO 0000305|PubMed 17170003}. # Organism YEFM_ECOLI Escherichia coli (strain K12) # PATRIC 32119371 VBIEscCol129921_2095 # PDB 2A6Q X-ray; 2.05 A; A/B/C/D=1-83 # PIR H64966 H64966 # Pfam PF02604 PhdYeFM_antitox # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEFM_ECOLI Antitoxin YefM # RefSeq NP_416521 NC_000913.3 # RefSeq WP_001259255 NZ_LN832404.1 # SIMILARITY Belongs to the phD/YefM antitoxin family. {ECO 0000305}. # SUBUNIT YEFM_ECOLI In solution exists as both a monomer and a dimer; the monomeric state is more predominant. It has been described as being a YefM-YeoB(2) heterotrimer (PubMed 15980067) and as a YefM(2)-YoeB heterotrimer (PubMed 16109374 and PubMed 17170003). When complexed with YoeB inhibits the toxin activity. {ECO 0000269|PubMed 15980067, ECO 0000269|PubMed 16109374, ECO 0000269|PubMed 17170003}. # TIGRFAMs TIGR01552 phd_fam # eggNOG COG2161 LUCA # eggNOG ENOG4105VTW Bacteria BLAST swissprot:YEFM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEFM_ECOLI BioCyc ECOL316407:JW5835-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5835-MONOMER BioCyc EcoCyc:EG12844-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12844-MONOMER BioCyc MetaCyc:EG12844-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12844-MONOMER DOI 10.1016/j.molcel.2005.07.004 http://dx.doi.org/10.1016/j.molcel.2005.07.004 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2003.03941.x http://dx.doi.org/10.1046/j.1365-2958.2003.03941.x DOI 10.1074/jbc.M308263200 http://dx.doi.org/10.1074/jbc.M308263200 DOI 10.1074/jbc.M506220200 http://dx.doi.org/10.1074/jbc.M506220200 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1093/nar/9.9.2075 http://dx.doi.org/10.1093/nar/9.9.2075 DOI 10.1093/nar/gkl1028 http://dx.doi.org/10.1093/nar/gkl1028 DOI 10.1111/j.1365-2958.2009.06694.x http://dx.doi.org/10.1111/j.1365-2958.2009.06694.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01331-08 http://dx.doi.org/10.1128/JB.01331-08 DOI 10.1186/1471-2180-6-53 http://dx.doi.org/10.1186/1471-2180-6-53 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00284 http://www.ebi.ac.uk/ena/data/view/V00284 EchoBASE EB2693 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2693 EcoGene EG12844 http://www.ecogene.org/geneInfo.php?eg_id=EG12844 EnsemblBacteria AAC75078 http://www.ensemblgenomes.org/id/AAC75078 EnsemblBacteria AAC75078 http://www.ensemblgenomes.org/id/AAC75078 EnsemblBacteria BAA15849 http://www.ensemblgenomes.org/id/BAA15849 EnsemblBacteria BAA15849 http://www.ensemblgenomes.org/id/BAA15849 EnsemblBacteria BAA15849 http://www.ensemblgenomes.org/id/BAA15849 EnsemblBacteria b2017 http://www.ensemblgenomes.org/id/b2017 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0015643 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015643 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0044010 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044010 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.1620.10 http://www.cathdb.info/version/latest/superfamily/3.40.1620.10 GeneID 946542 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946542 HOGENOM HOG000216358 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000216358&db=HOGENOM6 InParanoid P69346 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P69346 IntAct P69346 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69346* InterPro IPR006442 http://www.ebi.ac.uk/interpro/entry/IPR006442 KEGG_Gene ecj:JW5835 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5835 KEGG_Gene eco:b2017 http://www.genome.jp/dbget-bin/www_bget?eco:b2017 OMA AMEETAY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AMEETAY PDB 2A6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/2A6Q PDBsum 2A6Q http://www.ebi.ac.uk/pdbsum/2A6Q PSORT swissprot:YEFM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEFM_ECOLI PSORT-B swissprot:YEFM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEFM_ECOLI PSORT2 swissprot:YEFM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEFM_ECOLI Pfam PF02604 http://pfam.xfam.org/family/PF02604 Phobius swissprot:YEFM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEFM_ECOLI PhylomeDB P69346 http://phylomedb.org/?seqid=P69346 ProteinModelPortal P69346 http://www.proteinmodelportal.org/query/uniprot/P69346 PubMed 14672926 http://www.ncbi.nlm.nih.gov/pubmed/14672926 PubMed 15009896 http://www.ncbi.nlm.nih.gov/pubmed/15009896 PubMed 15980067 http://www.ncbi.nlm.nih.gov/pubmed/15980067 PubMed 16109374 http://www.ncbi.nlm.nih.gov/pubmed/16109374 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16768798 http://www.ncbi.nlm.nih.gov/pubmed/16768798 PubMed 17170003 http://www.ncbi.nlm.nih.gov/pubmed/17170003 PubMed 19028895 http://www.ncbi.nlm.nih.gov/pubmed/19028895 PubMed 19400780 http://www.ncbi.nlm.nih.gov/pubmed/19400780 PubMed 6170941 http://www.ncbi.nlm.nih.gov/pubmed/6170941 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416521 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416521 RefSeq WP_001259255 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001259255 SMR P69346 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69346 STRING 511145.b2017 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2017&targetmode=cogs TIGRFAMs TIGR01552 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01552 UniProtKB YEFM_ECOLI http://www.uniprot.org/uniprot/YEFM_ECOLI UniProtKB-AC P69346 http://www.uniprot.org/uniprot/P69346 charge swissprot:YEFM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEFM_ECOLI eggNOG COG2161 http://eggnogapi.embl.de/nog_data/html/tree/COG2161 eggNOG ENOG4105VTW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VTW epestfind swissprot:YEFM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEFM_ECOLI garnier swissprot:YEFM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEFM_ECOLI helixturnhelix swissprot:YEFM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEFM_ECOLI hmoment swissprot:YEFM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEFM_ECOLI iep swissprot:YEFM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEFM_ECOLI inforesidue swissprot:YEFM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEFM_ECOLI octanol swissprot:YEFM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEFM_ECOLI pepcoil swissprot:YEFM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEFM_ECOLI pepdigest swissprot:YEFM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEFM_ECOLI pepinfo swissprot:YEFM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEFM_ECOLI pepnet swissprot:YEFM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEFM_ECOLI pepstats swissprot:YEFM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEFM_ECOLI pepwheel swissprot:YEFM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEFM_ECOLI pepwindow swissprot:YEFM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEFM_ECOLI sigcleave swissprot:YEFM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEFM_ECOLI ## Database ID URL or Descriptions # BioGrid 4259422 9 # DOMAIN MZRA_ECOLI Interacts with EnvZ through its soluble periplasmic region. {ECO 0000269|PubMed 20889743}. # EcoGene EG12741 mzrA # FUNCTION MZRA_ECOLI Modulates the activity of the EnvZ/OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR. Links the two-component systems CpxA/CpxR and EnvZ/OmpR. {ECO 0000255|HAMAP-Rule MF_00904, ECO 0000269|PubMed 19432797, ECO 0000269|PubMed 20889743}. # GO_component GO:0005887 integral component of plasma membrane; IEA:UniProtKB-HAMAP. # GO_process GO:0045859 regulation of protein kinase activity; IEP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0008150 biological_process # HAMAP MF_00904 Modulator_MzrA # INDUCTION MZRA_ECOLI Regulated by the CpxA/CpxR two-component system. Negatively regulated by EnvZ/OmpR. {ECO 0000269|PubMed 16861804, ECO 0000269|PubMed 19432797}. # INTERACTION MZRA_ECOLI P0AEJ4 envZ; NbExp=3; IntAct=EBI-6412632, EBI-1121750; # InterPro IPR026574 Modulator_MzrA # InterPro IPR027398 SecD-TM # Organism MZRA_ECOLI Escherichia coli (strain K12) # PATRIC 32121612 VBIEscCol129921_3192 # PIR E65098 E65098 # Pfam PF13721 SecD-TM1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Modulator protein MzrA {ECO:0000255|HAMAP-Rule MF_00904} # RefSeq NP_417567 NC_000913.3 # RefSeq WP_001166760 NZ_LN832404.1 # SIMILARITY Belongs to the MzrA family. {ECO:0000255|HAMAP- Rule MF_00904}. # SUBCELLULAR LOCATION MZRA_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_00904, ECO 0000269|PubMed 19432797, ECO 0000269|PubMed 20889743}; Single-pass membrane protein {ECO 0000255|HAMAP-Rule MF_00904, ECO 0000269|PubMed 19432797, ECO 0000269|PubMed 20889743}. # SUBUNIT MZRA_ECOLI Interacts with EnvZ. {ECO 0000255|HAMAP-Rule MF_00904, ECO 0000269|PubMed 19432797, ECO 0000269|PubMed 20889743}. # eggNOG ENOG4105IYR Bacteria # eggNOG ENOG4112345 LUCA BLAST swissprot:MZRA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MZRA_ECOLI BioCyc ECOL316407:JW3067-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3067-MONOMER BioCyc EcoCyc:G7610-MONOMER http://biocyc.org/getid?id=EcoCyc:G7610-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2009.06728.x http://dx.doi.org/10.1111/j.1365-2958.2009.06728.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00855-10 http://dx.doi.org/10.1128/JB.00855-10 DOI 10.1271/bbb.60024 http://dx.doi.org/10.1271/bbb.60024 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2597 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2597 EcoGene EG12741 http://www.ecogene.org/geneInfo.php?eg_id=EG12741 EnsemblBacteria AAC76131 http://www.ensemblgenomes.org/id/AAC76131 EnsemblBacteria AAC76131 http://www.ensemblgenomes.org/id/AAC76131 EnsemblBacteria BAE77146 http://www.ensemblgenomes.org/id/BAE77146 EnsemblBacteria BAE77146 http://www.ensemblgenomes.org/id/BAE77146 EnsemblBacteria BAE77146 http://www.ensemblgenomes.org/id/BAE77146 EnsemblBacteria b3096 http://www.ensemblgenomes.org/id/b3096 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_process GO:0045859 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045859 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 947619 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947619 HAMAP MF_00904 http://hamap.expasy.org/unirule/MF_00904 HOGENOM HOG000125148 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125148&db=HOGENOM6 IntAct P42615 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P42615* InterPro IPR026574 http://www.ebi.ac.uk/interpro/entry/IPR026574 InterPro IPR027398 http://www.ebi.ac.uk/interpro/entry/IPR027398 KEGG_Gene ecj:JW3067 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3067 KEGG_Gene eco:b3096 http://www.genome.jp/dbget-bin/www_bget?eco:b3096 OMA KHETTLE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KHETTLE PSORT swissprot:MZRA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MZRA_ECOLI PSORT-B swissprot:MZRA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MZRA_ECOLI PSORT2 swissprot:MZRA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MZRA_ECOLI Pfam PF13721 http://pfam.xfam.org/family/PF13721 Phobius swissprot:MZRA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MZRA_ECOLI ProteinModelPortal P42615 http://www.proteinmodelportal.org/query/uniprot/P42615 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16861804 http://www.ncbi.nlm.nih.gov/pubmed/16861804 PubMed 19432797 http://www.ncbi.nlm.nih.gov/pubmed/19432797 PubMed 20889743 http://www.ncbi.nlm.nih.gov/pubmed/20889743 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417567 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417567 RefSeq WP_001166760 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001166760 SMR P42615 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P42615 STRING 511145.b3096 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3096&targetmode=cogs UniProtKB MZRA_ECOLI http://www.uniprot.org/uniprot/MZRA_ECOLI UniProtKB-AC P42615 http://www.uniprot.org/uniprot/P42615 charge swissprot:MZRA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MZRA_ECOLI eggNOG ENOG4105IYR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105IYR eggNOG ENOG4112345 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4112345 epestfind swissprot:MZRA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MZRA_ECOLI garnier swissprot:MZRA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MZRA_ECOLI helixturnhelix swissprot:MZRA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MZRA_ECOLI hmoment swissprot:MZRA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MZRA_ECOLI iep swissprot:MZRA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MZRA_ECOLI inforesidue swissprot:MZRA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MZRA_ECOLI octanol swissprot:MZRA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MZRA_ECOLI pepcoil swissprot:MZRA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MZRA_ECOLI pepdigest swissprot:MZRA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MZRA_ECOLI pepinfo swissprot:MZRA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MZRA_ECOLI pepnet swissprot:MZRA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MZRA_ECOLI pepstats swissprot:MZRA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MZRA_ECOLI pepwheel swissprot:MZRA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MZRA_ECOLI pepwindow swissprot:MZRA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MZRA_ECOLI sigcleave swissprot:MZRA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MZRA_ECOLI ## Database ID URL or Descriptions # AltName EIIA-Gut {ECO:0000303|PubMed 3553176} # AltName EIII-Gut {ECO:0000303|PubMed 3553176} # AltName Glucitol/sorbitol-specific phosphotransferase enzyme IIA component {ECO:0000303|PubMed 3553176} # BioGrid 4259356 11 # CATALYTIC ACTIVITY [Protein]-N(pi)-phospho-L-histidine + D- sorbitol(Side 1) = [protein]-L-histidine + D-sorbitol 6- phosphate(Side 2). {ECO:0000269|PubMed 1100608}. # DOMAIN PTHA_ECOLI The EIIA domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the EIIB domain. {ECO 0000255|PROSITE-ProRule PRU00420}. # EcoGene EG10970 srlB # FUNCTION PTHA_ECOLI The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II complex composed of SrlA, SrlB and SrlE is involved in glucitol/sorbitol transport. It can also use D- mannitol. {ECO 0000269|PubMed 1100608}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0008982 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:InterPro. # GO_function GO:0016301 kinase activity; IMP:EcoCyc. # GO_function GO:0016773 phosphotransferase activity, alcohol group as acceptor; IDA:UniProtKB. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IDA:UniProtKB. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # Gene3D 2.40.33.40 -; 1. # INDUCTION Regulated by an unusual system which consists of the activator GutM and the repressor GutR in addition to the cAMP-CRP complex. {ECO:0000269|PubMed 3062173}. # IntAct P05706 3 # InterPro IPR004716 PTS_IIA_glucitol/sorbitol-sp # InterPro IPR018454 PTS_IIA_glucitol/sorbitol_sub # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00280 PTS system, glucitol/sorbitol-specific II component # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko00051 Fructose and mannose metabolism # KEGG_Pathway ko02060 Phosphotransferase system (PTS) # Organism PTHA_ECOLI Escherichia coli (strain K12) # PATRIC 32120806 VBIEscCol129921_2795 # PIR B26725 WQEC3S # PROSITE PS51097 PTS_EIIA_TYPE_5 # Pfam PF03829 PTSIIA_gutA # ProDom PD015842 PTS_IIA_glucitol/sorbitol-sp # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PTS system glucitol/sorbitol-specific EIIA component {ECO:0000303|PubMed 3553176} # RefSeq NP_417184 NC_000913.3 # RefSeq WP_000216194 NZ_LN832404.1 # SIMILARITY Contains 1 PTS EIIA type-5 domain. {ECO:0000255|PROSITE-ProRule PRU00420}. # SUBCELLULAR LOCATION PTHA_ECOLI Cytoplasm {ECO 0000305|PubMed 3553176}. # SUPFAM SSF141530 SSF141530 # TCDB 4.A.4.1 the pts glucitol (gut) family # TIGRFAMs TIGR00849 gutA # eggNOG COG3731 LUCA # eggNOG ENOG4105VI0 Bacteria BLAST swissprot:PTHA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTHA_ECOLI BioCyc ECOL316407:JW2673-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2673-MONOMER BioCyc EcoCyc:GUTB-MONOMER http://biocyc.org/getid?id=EcoCyc:GUTB-MONOMER BioCyc MetaCyc:GUTB-MONOMER http://biocyc.org/getid?id=MetaCyc:GUTB-MONOMER COG COG3731 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3731 DOI 10.1016/0022-2836(88)90193-3 http://dx.doi.org/10.1016/0022-2836(88)90193-3 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.198 {ECO:0000269|PubMed:1100608} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.198 {ECO:0000269|PubMed:1100608} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J02708 http://www.ebi.ac.uk/ena/data/view/J02708 EMBL M93583 http://www.ebi.ac.uk/ena/data/view/M93583 EMBL M93585 http://www.ebi.ac.uk/ena/data/view/M93585 EMBL M93586 http://www.ebi.ac.uk/ena/data/view/M93586 EMBL M93588 http://www.ebi.ac.uk/ena/data/view/M93588 EMBL M93589 http://www.ebi.ac.uk/ena/data/view/M93589 EMBL M93590 http://www.ebi.ac.uk/ena/data/view/M93590 EMBL M93599 http://www.ebi.ac.uk/ena/data/view/M93599 EMBL M93600 http://www.ebi.ac.uk/ena/data/view/M93600 EMBL M93601 http://www.ebi.ac.uk/ena/data/view/M93601 EMBL M93602 http://www.ebi.ac.uk/ena/data/view/M93602 EMBL M93603 http://www.ebi.ac.uk/ena/data/view/M93603 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.198 {ECO:0000269|PubMed:1100608} http://enzyme.expasy.org/EC/2.7.1.198 {ECO:0000269|PubMed:1100608} EchoBASE EB0963 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0963 EcoGene EG10970 http://www.ecogene.org/geneInfo.php?eg_id=EG10970 EnsemblBacteria AAC75746 http://www.ensemblgenomes.org/id/AAC75746 EnsemblBacteria AAC75746 http://www.ensemblgenomes.org/id/AAC75746 EnsemblBacteria BAA16565 http://www.ensemblgenomes.org/id/BAA16565 EnsemblBacteria BAA16565 http://www.ensemblgenomes.org/id/BAA16565 EnsemblBacteria BAA16565 http://www.ensemblgenomes.org/id/BAA16565 EnsemblBacteria b2704 http://www.ensemblgenomes.org/id/b2704 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0008982 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008982 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_function GO:0016773 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016773 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 2.40.33.40 http://www.cathdb.info/version/latest/superfamily/2.40.33.40 GeneID 948971 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948971 InParanoid P05706 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P05706 IntAct P05706 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P05706* IntEnz 2.7.1.198 {ECO:0000269|PubMed:1100608} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.198 {ECO:0000269|PubMed:1100608} InterPro IPR004716 http://www.ebi.ac.uk/interpro/entry/IPR004716 InterPro IPR018454 http://www.ebi.ac.uk/interpro/entry/IPR018454 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2673 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2673 KEGG_Gene eco:b2704 http://www.genome.jp/dbget-bin/www_bget?eco:b2704 KEGG_Orthology KO:K02781 http://www.genome.jp/dbget-bin/www_bget?KO:K02781 KEGG_Pathway ko00051 http://www.genome.jp/kegg-bin/show_pathway?ko00051 KEGG_Pathway ko02060 http://www.genome.jp/kegg-bin/show_pathway?ko02060 KEGG_Reaction rn:R05820 http://www.genome.jp/dbget-bin/www_bget?rn:R05820 OMA YQTTITH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YQTTITH PROSITE PS51097 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51097 PSORT swissprot:PTHA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTHA_ECOLI PSORT-B swissprot:PTHA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTHA_ECOLI PSORT2 swissprot:PTHA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTHA_ECOLI Pfam PF03829 http://pfam.xfam.org/family/PF03829 Phobius swissprot:PTHA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTHA_ECOLI PhylomeDB P05706 http://phylomedb.org/?seqid=P05706 ProteinModelPortal P05706 http://www.proteinmodelportal.org/query/uniprot/P05706 PubMed 1100608 http://www.ncbi.nlm.nih.gov/pubmed/1100608 PubMed 1630305 http://www.ncbi.nlm.nih.gov/pubmed/1630305 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3062173 http://www.ncbi.nlm.nih.gov/pubmed/3062173 PubMed 3553176 http://www.ncbi.nlm.nih.gov/pubmed/3553176 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417184 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417184 RefSeq WP_000216194 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000216194 SMR P05706 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P05706 STRING 511145.b2704 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2704&targetmode=cogs STRING COG3731 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3731&targetmode=cogs SUPFAM SSF141530 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF141530 TCDB 4.A.4.1 http://www.tcdb.org/search/result.php?tc=4.A.4.1 TIGRFAMs TIGR00849 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00849 UniProtKB PTHA_ECOLI http://www.uniprot.org/uniprot/PTHA_ECOLI UniProtKB-AC P05706 http://www.uniprot.org/uniprot/P05706 charge swissprot:PTHA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTHA_ECOLI eggNOG COG3731 http://eggnogapi.embl.de/nog_data/html/tree/COG3731 eggNOG ENOG4105VI0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VI0 epestfind swissprot:PTHA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTHA_ECOLI garnier swissprot:PTHA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTHA_ECOLI helixturnhelix swissprot:PTHA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTHA_ECOLI hmoment swissprot:PTHA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTHA_ECOLI iep swissprot:PTHA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTHA_ECOLI inforesidue swissprot:PTHA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTHA_ECOLI octanol swissprot:PTHA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTHA_ECOLI pepcoil swissprot:PTHA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTHA_ECOLI pepdigest swissprot:PTHA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTHA_ECOLI pepinfo swissprot:PTHA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTHA_ECOLI pepnet swissprot:PTHA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTHA_ECOLI pepstats swissprot:PTHA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTHA_ECOLI pepwheel swissprot:PTHA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTHA_ECOLI pepwindow swissprot:PTHA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTHA_ECOLI sigcleave swissprot:PTHA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTHA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261043 14 # EcoGene EG11224 fliO # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0009425 bacterial-type flagellum basal body; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006935 chemotaxis; IEA:UniProtKB-KW. # GO_process GO:0044781 bacterial-type flagellum organization; IEA:InterPro. # GO_process GO:0097588 archaeal or bacterial-type flagellum-dependent cell motility; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0008150 biological_process # GOslim_process GO:0040011 locomotion # GOslim_process GO:0048870 cell motility # InterPro IPR022781 Flagellar_biosynth_FliO # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko02040 Flagellar assembly # Organism FLIO_ECOLI Escherichia coli (strain K12) # PATRIC 32119223 VBIEscCol129921_2026 # Pfam PF04347 FliO # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FLIO_ECOLI Flagellar protein FliO # RefSeq NP_416457 NC_000913.3 # RefSeq WP_001302429 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAC36858.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the FliO/MopB family. {ECO 0000305}. # SUBCELLULAR LOCATION FLIO_ECOLI Cell membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. Bacterial flagellum basal body {ECO 0000250}. # TIGRFAMs TIGR03500 FliO_TIGR # eggNOG COG3190 LUCA # eggNOG ENOG4105K0P Bacteria BLAST swissprot:FLIO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLIO_ECOLI BioCyc ECOL316407:JW5316-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5316-MONOMER BioCyc EcoCyc:EG11224-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11224-MONOMER COG COG3190 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3190 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L22182 http://www.ebi.ac.uk/ena/data/view/L22182 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1206 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1206 EcoGene EG11224 http://www.ecogene.org/geneInfo.php?eg_id=EG11224 EnsemblBacteria AAC75014 http://www.ensemblgenomes.org/id/AAC75014 EnsemblBacteria AAC75014 http://www.ensemblgenomes.org/id/AAC75014 EnsemblBacteria BAA15772 http://www.ensemblgenomes.org/id/BAA15772 EnsemblBacteria BAA15772 http://www.ensemblgenomes.org/id/BAA15772 EnsemblBacteria BAA15772 http://www.ensemblgenomes.org/id/BAA15772 EnsemblBacteria b1947 http://www.ensemblgenomes.org/id/b1947 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0009425 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009425 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006935 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006935 GO_process GO:0044781 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044781 GO_process GO:0097588 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097588 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0040011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 GeneID 946458 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946458 HOGENOM HOG000253556 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000253556&db=HOGENOM6 IntAct P22586 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P22586* InterPro IPR022781 http://www.ebi.ac.uk/interpro/entry/IPR022781 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW5316 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5316 KEGG_Gene eco:b1947 http://www.genome.jp/dbget-bin/www_bget?eco:b1947 KEGG_Orthology KO:K02418 http://www.genome.jp/dbget-bin/www_bget?KO:K02418 KEGG_Pathway ko02040 http://www.genome.jp/kegg-bin/show_pathway?ko02040 OMA KRMQVPA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KRMQVPA PSORT swissprot:FLIO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLIO_ECOLI PSORT-B swissprot:FLIO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLIO_ECOLI PSORT2 swissprot:FLIO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLIO_ECOLI Pfam PF04347 http://pfam.xfam.org/family/PF04347 Phobius swissprot:FLIO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLIO_ECOLI ProteinModelPortal P22586 http://www.proteinmodelportal.org/query/uniprot/P22586 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8282695 http://www.ncbi.nlm.nih.gov/pubmed/8282695 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416457 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416457 RefSeq WP_001302429 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001302429 STRING 511145.b1947 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1947&targetmode=cogs STRING COG3190 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3190&targetmode=cogs TIGRFAMs TIGR03500 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03500 UniProtKB FLIO_ECOLI http://www.uniprot.org/uniprot/FLIO_ECOLI UniProtKB-AC P22586 http://www.uniprot.org/uniprot/P22586 charge swissprot:FLIO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLIO_ECOLI eggNOG COG3190 http://eggnogapi.embl.de/nog_data/html/tree/COG3190 eggNOG ENOG4105K0P http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K0P epestfind swissprot:FLIO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLIO_ECOLI garnier swissprot:FLIO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLIO_ECOLI helixturnhelix swissprot:FLIO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLIO_ECOLI hmoment swissprot:FLIO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLIO_ECOLI iep swissprot:FLIO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLIO_ECOLI inforesidue swissprot:FLIO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLIO_ECOLI octanol swissprot:FLIO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLIO_ECOLI pepcoil swissprot:FLIO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLIO_ECOLI pepdigest swissprot:FLIO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLIO_ECOLI pepinfo swissprot:FLIO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLIO_ECOLI pepnet swissprot:FLIO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLIO_ECOLI pepstats swissprot:FLIO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLIO_ECOLI pepwheel swissprot:FLIO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLIO_ECOLI pepwindow swissprot:FLIO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLIO_ECOLI sigcleave swissprot:FLIO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLIO_ECOLI ## Database ID URL or Descriptions # BioGrid 4259696 170 # CAZy GT2 Glycosyltransferase Family 2 # EcoGene EG13573 wcaE # GO_function GO:0016757 transferase activity, transferring glycosyl groups; IBA:GO_Central. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0045228 slime layer polysaccharide biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.90.550.10 -; 1. # InterPro IPR001173 Glyco_trans_2-like # InterPro IPR024010 Colanic_acid_synth_WcaE # InterPro IPR029044 Nucleotide-diphossugar_trans # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01003 Glycosyltransferases # Organism WCAE_ECOLI Escherichia coli (strain K12) # PATHWAY WCAE_ECOLI Slime biogenesis; slime polysaccharide biosynthesis. # PATRIC 32119443 VBIEscCol129921_2132 # PIR F64971 F64971 # Pfam PF00535 Glycos_transf_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName WCAE_ECOLI Putative colanic acid biosynthesis glycosyl transferase WcaE # RefSeq NP_416559 NC_000913.3 # RefSeq WP_000927089 NZ_LN832404.1 # SUPFAM SSF53448 SSF53448 # TIGRFAMs TIGR04009 wcaE # eggNOG COG0463 LUCA # eggNOG ENOG4105ECJ Bacteria BLAST swissprot:WCAE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:WCAE_ECOLI BioCyc ECOL316407:JW2040-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2040-MONOMER BioCyc EcoCyc:G7100-MONOMER http://biocyc.org/getid?id=EcoCyc:G7100-MONOMER COG CAZy: http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=CAZy: COG COG0463 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0463 COG GT2 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=GT2 DIP DIP-11121N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11121N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U38473 http://www.ebi.ac.uk/ena/data/view/U38473 EchoBASE EB3343 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3343 EcoGene EG13573 http://www.ecogene.org/geneInfo.php?eg_id=EG13573 EnsemblBacteria AAC75116 http://www.ensemblgenomes.org/id/AAC75116 EnsemblBacteria AAC75116 http://www.ensemblgenomes.org/id/AAC75116 EnsemblBacteria BAE76572 http://www.ensemblgenomes.org/id/BAE76572 EnsemblBacteria BAE76572 http://www.ensemblgenomes.org/id/BAE76572 EnsemblBacteria BAE76572 http://www.ensemblgenomes.org/id/BAE76572 EnsemblBacteria b2055 http://www.ensemblgenomes.org/id/b2055 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GO_process GO:0045228 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045228 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.90.550.10 http://www.cathdb.info/version/latest/superfamily/3.90.550.10 GeneID 946543 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946543 HOGENOM HOG000024873 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000024873&db=HOGENOM6 InParanoid P71239 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P71239 IntAct P71239 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P71239* InterPro IPR001173 http://www.ebi.ac.uk/interpro/entry/IPR001173 InterPro IPR024010 http://www.ebi.ac.uk/interpro/entry/IPR024010 InterPro IPR029044 http://www.ebi.ac.uk/interpro/entry/IPR029044 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01003 http://www.genome.jp/dbget-bin/www_bget?ko01003 KEGG_Gene ecj:JW2040 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2040 KEGG_Gene eco:b2055 http://www.genome.jp/dbget-bin/www_bget?eco:b2055 KEGG_Orthology KO:K13683 http://www.genome.jp/dbget-bin/www_bget?KO:K13683 OMA YKSGYPF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YKSGYPF PSORT swissprot:WCAE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:WCAE_ECOLI PSORT-B swissprot:WCAE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:WCAE_ECOLI PSORT2 swissprot:WCAE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:WCAE_ECOLI Pfam PF00535 http://pfam.xfam.org/family/PF00535 Phobius swissprot:WCAE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:WCAE_ECOLI PhylomeDB P71239 http://phylomedb.org/?seqid=P71239 ProteinModelPortal P71239 http://www.proteinmodelportal.org/query/uniprot/P71239 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8759852 http://www.ncbi.nlm.nih.gov/pubmed/8759852 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416559 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416559 RefSeq WP_000927089 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000927089 STRING 511145.b2055 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2055&targetmode=cogs STRING CAZy: http://string-db.org/newstring_cgi/show_network_section.pl?identifier=CAZy:&targetmode=cogs STRING COG0463 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0463&targetmode=cogs STRING GT2 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=GT2&targetmode=cogs SUPFAM SSF53448 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53448 TIGRFAMs TIGR04009 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR04009 UniProtKB WCAE_ECOLI http://www.uniprot.org/uniprot/WCAE_ECOLI UniProtKB-AC P71239 http://www.uniprot.org/uniprot/P71239 charge swissprot:WCAE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:WCAE_ECOLI eggNOG COG0463 http://eggnogapi.embl.de/nog_data/html/tree/COG0463 eggNOG ENOG4105ECJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ECJ epestfind swissprot:WCAE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:WCAE_ECOLI garnier swissprot:WCAE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:WCAE_ECOLI helixturnhelix swissprot:WCAE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:WCAE_ECOLI hmoment swissprot:WCAE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:WCAE_ECOLI iep swissprot:WCAE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:WCAE_ECOLI inforesidue swissprot:WCAE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:WCAE_ECOLI octanol swissprot:WCAE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:WCAE_ECOLI pepcoil swissprot:WCAE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:WCAE_ECOLI pepdigest swissprot:WCAE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:WCAE_ECOLI pepinfo swissprot:WCAE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:WCAE_ECOLI pepnet swissprot:WCAE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:WCAE_ECOLI pepstats swissprot:WCAE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:WCAE_ECOLI pepwheel swissprot:WCAE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:WCAE_ECOLI pepwindow swissprot:WCAE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:WCAE_ECOLI sigcleave swissprot:WCAE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:WCAE_ECOLI ## Database ID URL or Descriptions # AltName RL35_ECOLI Ribosomal protein A # BioGrid 4262931 15 # EcoGene EG11231 rpmI # GO_component GO:0022625 cytosolic large ribosomal subunit; IDA:EcoCyc. # GO_function GO:0003735 structural constituent of ribosome; IDA:EcoCyc. # GO_process GO:0006412 translation; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_process GO:0006412 translation # HAMAP MF_00514 Ribosomal_L35 # IntAct P0A7Q1 4 # InterPro IPR001706 Ribosomal_L35_non-mt # InterPro IPR018265 Ribosomal_L35_CS # InterPro IPR021137 Ribosomal_L35 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=7158.0; Method=MALDI; Range=2-65; Evidence={ECO:0000269|PubMed 10094780}; # Organism RL35_ECOLI Escherichia coli (strain K12) # PATRIC 32118738 VBIEscCol129921_1787 # PDB 2J28 EM; 8.00 A; 3=2-65 # PDB 2RDO EM; 9.10 A; 3=2-65 # PDB 3BBX EM; 10.00 A; 3=2-65 # PDB 3J5L EM; 6.60 A; 3=2-65 # PDB 3J7Z EM; 3.90 A; 3=1-65 # PDB 3J8G EM; 5.00 A; 7=1-65 # PDB 3J9Y EM; 3.90 A; 3=1-65 # PDB 3J9Z EM; 3.60 A; L4=2-65 # PDB 3JA1 EM; 3.60 A; L6=2-65 # PDB 3JBU EM; 3.64 A; 7=1-65 # PDB 3JBV EM; 3.32 A; 7=1-65 # PDB 3JCD EM; 3.70 A; 3=2-65 # PDB 3JCE EM; 3.20 A; 3=1-65 # PDB 3JCJ EM; 3.70 A; c=1-65 # PDB 3JCN EM; 4.60 A; 3=1-65 # PDB 4CSU EM; 5.50 A; 7=2-65 # PDB 4U1U X-ray; 2.95 A; B3/D3=2-65 # PDB 4U1V X-ray; 3.00 A; B3/D3=2-65 # PDB 4U20 X-ray; 2.90 A; B3/D3=2-65 # PDB 4U24 X-ray; 2.90 A; B3/D3=2-65 # PDB 4U25 X-ray; 2.90 A; B3/D3=2-65 # PDB 4U26 X-ray; 2.80 A; B3/D3=2-65 # PDB 4U27 X-ray; 2.80 A; B3/D3=2-65 # PDB 4UY8 EM; 3.80 A; 3=2-65 # PDB 4V4H X-ray; 3.46 A; B3/D3=1-65 # PDB 4V4Q X-ray; 3.46 A; B3/D3=2-65 # PDB 4V50 X-ray; 3.22 A; B3/D3=2-65 # PDB 4V52 X-ray; 3.21 A; B3/D3=2-65 # PDB 4V53 X-ray; 3.54 A; B3/D3=2-65 # PDB 4V54 X-ray; 3.30 A; B3/D3=2-65 # PDB 4V55 X-ray; 4.00 A; B3/D3=2-65 # PDB 4V56 X-ray; 3.93 A; B3/D3=2-65 # PDB 4V57 X-ray; 3.50 A; B3/D3=2-65 # PDB 4V5B X-ray; 3.74 A; A3/C3=2-65 # PDB 4V5H EM; 5.80 A; B7=2-65 # PDB 4V5Y X-ray; 4.45 A; B3/D3=2-65 # PDB 4V64 X-ray; 3.50 A; B3/D3=2-65 # PDB 4V65 EM; 9.00 A; BW=2-65 # PDB 4V66 EM; 9.00 A; BW=2-65 # PDB 4V69 EM; 6.70 A; B3=2-65 # PDB 4V6C X-ray; 3.19 A; B3/D3=1-65 # PDB 4V6D X-ray; 3.81 A; B3/D3=1-65 # PDB 4V6E X-ray; 3.71 A; B3/D3=1-65 # PDB 4V6K EM; 8.25 A; Af=1-65 # PDB 4V6L EM; 13.20 A; Bf=1-65 # PDB 4V6M EM; 7.10 A; B3=2-65 # PDB 4V6N EM; 12.10 A; A6=2-65 # PDB 4V6O EM; 14.70 A; B6=2-65 # PDB 4V6P EM; 13.50 A; B6=2-65 # PDB 4V6Q EM; 11.50 A; B6=2-65 # PDB 4V6R EM; 11.50 A; B6=2-65 # PDB 4V6S EM; 13.10 A; A6=2-65 # PDB 4V6T EM; 8.30 A; B3=2-65 # PDB 4V6V EM; 9.80 A; B8=2-65 # PDB 4V6Y EM; 12.00 A; B3=1-65 # PDB 4V6Z EM; 12.00 A; B3=1-65 # PDB 4V70 EM; 17.00 A; B3=1-65 # PDB 4V71 EM; 20.00 A; B3=1-65 # PDB 4V72 EM; 13.00 A; B3=1-65 # PDB 4V73 EM; 15.00 A; B3=1-65 # PDB 4V74 EM; 17.00 A; B3=1-65 # PDB 4V75 EM; 12.00 A; B3=1-65 # PDB 4V76 EM; 17.00 A; B3=1-65 # PDB 4V77 EM; 17.00 A; B3=1-65 # PDB 4V78 EM; 20.00 A; B3=1-65 # PDB 4V79 EM; 15.00 A; B3=1-65 # PDB 4V7A EM; 9.00 A; B3=1-65 # PDB 4V7B EM; 6.80 A; B3=1-65 # PDB 4V7C EM; 7.60 A; B6=2-65 # PDB 4V7D EM; 7.60 A; A7=2-65 # PDB 4V7I EM; 9.60 A; A3=1-65 # PDB 4V7S X-ray; 3.25 A; B3/D3=2-65 # PDB 4V7T X-ray; 3.19 A; B3/D3=2-65 # PDB 4V7U X-ray; 3.10 A; B3/D3=2-65 # PDB 4V7V X-ray; 3.29 A; B3/D3=2-65 # PDB 4V85 X-ray; 3.20 A; 7=1-65 # PDB 4V89 X-ray; 3.70 A; B7=1-65 # PDB 4V9C X-ray; 3.30 A; B3/D3=1-65 # PDB 4V9D X-ray; 3.00 A; C3/D3=2-65 # PDB 4V9O X-ray; 2.90 A; A3/C3/E3/G3=1-65 # PDB 4V9P X-ray; 2.90 A; A3/C3/E3/G3=1-65 # PDB 4WF1 X-ray; 3.09 A; B3/D3=2-65 # PDB 4WOI X-ray; 3.00 A; B3/C3=1-65 # PDB 4WWW X-ray; 3.10 A; R3/Y3=2-65 # PDB 4YBB X-ray; 2.10 A; C4/D4=2-65 # PDB 5ADY EM; 4.50 A; 3=1-65 # PDB 5AFI EM; 2.90 A; 3=1-65 # PDB 5AKA EM; 5.70 A; 3=2-65 # PDB 5GAD EM; 3.70 A; e=1-65 # PDB 5GAE EM; 3.33 A; e=1-65 # PDB 5GAF EM; 4.30 A; e=2-65 # PDB 5GAG EM; 3.80 A; e=1-65 # PDB 5GAH EM; 3.80 A; e=1-65 # PDB 5IQR EM; 3.00 A; e=1-65 # PDB 5IT8 X-ray; 3.12 A; C4/D4=2-65 # PDB 5J5B X-ray; 2.80 A; C4/D4=2-65 # PDB 5J7L X-ray; 3.00 A; C4/D4=2-65 # PDB 5J88 X-ray; 3.32 A; C4/D4=2-65 # PDB 5J8A X-ray; 3.10 A; C4/D4=2-65 # PDB 5J91 X-ray; 2.96 A; C4/D4=2-65 # PDB 5JC9 X-ray; 3.03 A; C4/D4=2-65 # PDB 5JTE EM; 3.60 A; B3=1-65 # PDB 5JU8 EM; 3.60 A; B3=1-65 # PDB 5KCR EM; 3.60 A; 18=1-65 # PDB 5KCS EM; 3.90 A; 18=1-65 # PDB 5KPS EM; 3.90 A; 5=1-65 # PDB 5KPV EM; 4.10 A; 4=1-65 # PDB 5KPW EM; 3.90 A; 4=1-65 # PDB 5KPX EM; 3.90 A; 4=1-65 # PDB 5L3P EM; 3.70 A; 8=1-65 # PIR E64930 R5EC35 # PRINTS PR00064 RIBOSOMALL35 # PROSITE PS00936 RIBOSOMAL_L35 # Pfam PF01632 Ribosomal_L35p # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RL35_ECOLI 50S ribosomal protein L35 # RefSeq NP_416232 NC_000913.3 # RefSeq WP_001124225 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=V00291; Type=Frameshift; Positions=6; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ribosomal protein L35P family. {ECO 0000305}. # TIGRFAMs TIGR00001 rpmI_bact # eggNOG COG0291 LUCA BLAST swissprot:RL35_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RL35_ECOLI BioCyc ECOL316407:JW1707-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1707-MONOMER BioCyc EcoCyc:EG11231-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11231-MONOMER BioCyc MetaCyc:EG11231-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11231-MONOMER COG COG0291 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0291 DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1016/0167-4838(87)90007-0 http://dx.doi.org/10.1016/0167-4838(87)90007-0 DOI 10.1016/j.celrep.2014.09.011 http://dx.doi.org/10.1016/j.celrep.2014.09.011 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pbio.1001866 http://dx.doi.org/10.1371/journal.pbio.1001866 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00291 http://www.ebi.ac.uk/ena/data/view/V00291 EchoBASE EB1213 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1213 EcoGene EG11231 http://www.ecogene.org/geneInfo.php?eg_id=EG11231 EnsemblBacteria AAC74787 http://www.ensemblgenomes.org/id/AAC74787 EnsemblBacteria AAC74787 http://www.ensemblgenomes.org/id/AAC74787 EnsemblBacteria BAA15484 http://www.ensemblgenomes.org/id/BAA15484 EnsemblBacteria BAA15484 http://www.ensemblgenomes.org/id/BAA15484 EnsemblBacteria BAA15484 http://www.ensemblgenomes.org/id/BAA15484 EnsemblBacteria b1717 http://www.ensemblgenomes.org/id/b1717 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0022625 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022625 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GeneID 5552405 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5552405 GeneID 946349 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946349 HAMAP MF_00514 http://hamap.expasy.org/unirule/MF_00514 HOGENOM HOG000040108 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000040108&db=HOGENOM6 InParanoid P0A7Q1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7Q1 IntAct P0A7Q1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7Q1* InterPro IPR001706 http://www.ebi.ac.uk/interpro/entry/IPR001706 InterPro IPR018265 http://www.ebi.ac.uk/interpro/entry/IPR018265 InterPro IPR021137 http://www.ebi.ac.uk/interpro/entry/IPR021137 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW1707 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1707 KEGG_Gene eco:b1717 http://www.genome.jp/dbget-bin/www_bget?eco:b1717 KEGG_Orthology KO:K02916 http://www.genome.jp/dbget-bin/www_bget?KO:K02916 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 OMA FKCKQSH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FKCKQSH PDB 2J28 http://www.ebi.ac.uk/pdbe-srv/view/entry/2J28 PDB 2RDO http://www.ebi.ac.uk/pdbe-srv/view/entry/2RDO PDB 3BBX http://www.ebi.ac.uk/pdbe-srv/view/entry/3BBX PDB 3J5L http://www.ebi.ac.uk/pdbe-srv/view/entry/3J5L PDB 3J7Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J7Z PDB 3J8G http://www.ebi.ac.uk/pdbe-srv/view/entry/3J8G PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 4CSU http://www.ebi.ac.uk/pdbe-srv/view/entry/4CSU PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4UY8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4UY8 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5ADY http://www.ebi.ac.uk/pdbe-srv/view/entry/5ADY PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5AKA http://www.ebi.ac.uk/pdbe-srv/view/entry/5AKA PDB 5GAD http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAD PDB 5GAE http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAE PDB 5GAF http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAF PDB 5GAG http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAG PDB 5GAH http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAH PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 2J28 http://www.ebi.ac.uk/pdbsum/2J28 PDBsum 2RDO http://www.ebi.ac.uk/pdbsum/2RDO PDBsum 3BBX http://www.ebi.ac.uk/pdbsum/3BBX PDBsum 3J5L http://www.ebi.ac.uk/pdbsum/3J5L PDBsum 3J7Z http://www.ebi.ac.uk/pdbsum/3J7Z PDBsum 3J8G http://www.ebi.ac.uk/pdbsum/3J8G PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 4CSU http://www.ebi.ac.uk/pdbsum/4CSU PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4UY8 http://www.ebi.ac.uk/pdbsum/4UY8 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5ADY http://www.ebi.ac.uk/pdbsum/5ADY PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5AKA http://www.ebi.ac.uk/pdbsum/5AKA PDBsum 5GAD http://www.ebi.ac.uk/pdbsum/5GAD PDBsum 5GAE http://www.ebi.ac.uk/pdbsum/5GAE PDBsum 5GAF http://www.ebi.ac.uk/pdbsum/5GAF PDBsum 5GAG http://www.ebi.ac.uk/pdbsum/5GAG PDBsum 5GAH http://www.ebi.ac.uk/pdbsum/5GAH PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PRINTS PR00064 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00064 PROSITE PS00936 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00936 PSORT swissprot:RL35_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RL35_ECOLI PSORT-B swissprot:RL35_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RL35_ECOLI PSORT2 swissprot:RL35_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RL35_ECOLI Pfam PF01632 http://pfam.xfam.org/family/PF01632 Phobius swissprot:RL35_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RL35_ECOLI ProteinModelPortal P0A7Q1 http://www.proteinmodelportal.org/query/uniprot/P0A7Q1 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 24844575 http://www.ncbi.nlm.nih.gov/pubmed/24844575 PubMed 25310980 http://www.ncbi.nlm.nih.gov/pubmed/25310980 PubMed 3298224 http://www.ncbi.nlm.nih.gov/pubmed/3298224 PubMed 3542048 http://www.ncbi.nlm.nih.gov/pubmed/3542048 PubMed 6325158 http://www.ncbi.nlm.nih.gov/pubmed/6325158 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416232 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416232 RefSeq WP_001124225 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001124225 SMR P0A7Q1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7Q1 STRING 511145.b1717 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1717&targetmode=cogs STRING COG0291 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0291&targetmode=cogs TIGRFAMs TIGR00001 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00001 UniProtKB RL35_ECOLI http://www.uniprot.org/uniprot/RL35_ECOLI UniProtKB-AC P0A7Q1 http://www.uniprot.org/uniprot/P0A7Q1 charge swissprot:RL35_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RL35_ECOLI eggNOG COG0291 http://eggnogapi.embl.de/nog_data/html/tree/COG0291 epestfind swissprot:RL35_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RL35_ECOLI garnier swissprot:RL35_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RL35_ECOLI helixturnhelix swissprot:RL35_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RL35_ECOLI hmoment swissprot:RL35_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RL35_ECOLI iep swissprot:RL35_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RL35_ECOLI inforesidue swissprot:RL35_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RL35_ECOLI octanol swissprot:RL35_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RL35_ECOLI pepcoil swissprot:RL35_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RL35_ECOLI pepdigest swissprot:RL35_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RL35_ECOLI pepinfo swissprot:RL35_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RL35_ECOLI pepnet swissprot:RL35_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RL35_ECOLI pepstats swissprot:RL35_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RL35_ECOLI pepwheel swissprot:RL35_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RL35_ECOLI pepwindow swissprot:RL35_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RL35_ECOLI sigcleave swissprot:RL35_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RL35_ECOLI ## Database ID URL or Descriptions # AltName ARSCL_ECOLI Arsenical pump modifier # BioGrid 4260630 11 # CATALYTIC ACTIVITY ARSCL_ECOLI Arsenate + glutaredoxin = arsenite + glutaredoxin disulfide + H(2)O. # CAUTION The corresponding gene in K12 / MG1655 has a C-terminal deletion. {ECO 0000305}. # FUNCTION ARSCL_ECOLI Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of ArsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance (By similarity). {ECO 0000250}. # GO_function GO:0008794 arsenate reductase (glutaredoxin) activity; IEA:UniProtKB-EC. # GO_process GO:0046685 response to arsenic-containing substance; IEA:UniProtKB-KW. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0008150 biological_process # Gene3D 3.40.30.10 -; 1. # InterPro IPR006660 Arsenate_reductase-like # InterPro IPR012336 Thioredoxin-like_fold # Organism ARSCL_ECOLI Escherichia coli (strain K12) # PATRIC 48664682 VBIEscCol107702_2669 # PIR T08649 T08649 # PROSITE PS51353 ARSC # RecName ARSCL_ECOLI Putative arsenate reductase # RefSeq WP_000065803 NZ_LN832404.1 # SIMILARITY Belongs to the ArsC family. {ECO 0000305}. # SUPFAM SSF52833 SSF52833 # eggNOG COG1393 LUCA BLAST swissprot:ARSCL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARSCL_ECOLI DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 EC_number EC:1.20.4.1 http://www.genome.jp/dbget-bin/www_bget?EC:1.20.4.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U36840 http://www.ebi.ac.uk/ena/data/view/U36840 ENZYME 1.20.4.1 http://enzyme.expasy.org/EC/1.20.4.1 EnsemblBacteria BAA16506 http://www.ensemblgenomes.org/id/BAA16506 EnsemblBacteria BAA16506 http://www.ensemblgenomes.org/id/BAA16506 EnsemblBacteria BAA16506 http://www.ensemblgenomes.org/id/BAA16506 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008794 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008794 GO_process GO:0046685 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046685 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.30.10 http://www.cathdb.info/version/latest/superfamily/3.40.30.10 IntEnz 1.20.4.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.20.4.1 InterPro IPR006660 http://www.ebi.ac.uk/interpro/entry/IPR006660 InterPro IPR012336 http://www.ebi.ac.uk/interpro/entry/IPR012336 KEGG_Gene ecj:JW2619 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2619 PROSITE PS51353 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51353 PSORT swissprot:ARSCL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARSCL_ECOLI PSORT-B swissprot:ARSCL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARSCL_ECOLI PSORT2 swissprot:ARSCL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARSCL_ECOLI Phobius swissprot:ARSCL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARSCL_ECOLI ProteinModelPortal P0CF87 http://www.proteinmodelportal.org/query/uniprot/P0CF87 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 RefSeq WP_000065803 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000065803 SMR P0CF87 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0CF87 STRING 316407.85675501 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85675501&targetmode=cogs SUPFAM SSF52833 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52833 UniProtKB ARSCL_ECOLI http://www.uniprot.org/uniprot/ARSCL_ECOLI UniProtKB-AC P0CF87 http://www.uniprot.org/uniprot/P0CF87 charge swissprot:ARSCL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARSCL_ECOLI eggNOG COG1393 http://eggnogapi.embl.de/nog_data/html/tree/COG1393 epestfind swissprot:ARSCL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARSCL_ECOLI garnier swissprot:ARSCL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARSCL_ECOLI helixturnhelix swissprot:ARSCL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARSCL_ECOLI hmoment swissprot:ARSCL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARSCL_ECOLI iep swissprot:ARSCL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARSCL_ECOLI inforesidue swissprot:ARSCL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARSCL_ECOLI octanol swissprot:ARSCL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARSCL_ECOLI pepcoil swissprot:ARSCL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARSCL_ECOLI pepdigest swissprot:ARSCL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARSCL_ECOLI pepinfo swissprot:ARSCL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARSCL_ECOLI pepnet swissprot:ARSCL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARSCL_ECOLI pepstats swissprot:ARSCL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARSCL_ECOLI pepwheel swissprot:ARSCL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARSCL_ECOLI pepwindow swissprot:ARSCL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARSCL_ECOLI sigcleave swissprot:ARSCL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARSCL_ECOLI ## Database ID URL or Descriptions # BRENDA 1.15.1 2026 # BioGrid 4260265 58 # CATALYTIC ACTIVITY 2 superoxide + 2 H(+) = O(2) + H(2)O(2). {ECO:0000269|PubMed 9125513}. # COFACTOR SODF_ECOLI Name=Fe cation; Xref=ChEBI CHEBI 24875; Evidence={ECO 0000269|PubMed 9125513}; Note=Binds 1 Fe cation per subunit. {ECO 0000269|PubMed 9125513}; # EcoGene EG10954 sodB # FUNCTION SODF_ECOLI Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0004784 superoxide dismutase activity; IDA:EcoliWiki. # GO_function GO:0005506 iron ion binding; IDA:EcoCyc. # GO_function GO:0016491 oxidoreductase activity; IDA:EcoliWiki. # GO_process GO:0000303 response to superoxide; IDA:EcoliWiki. # GO_process GO:0006801 superoxide metabolic process; IDA:EcoliWiki. # GO_process GO:0019430 removal of superoxide radicals; IDA:EcoliWiki. # GO_process GO:0055114 oxidation-reduction process; IDA:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # IntAct P0AGD3 6 # InterPro IPR001189 Mn/Fe_SOD # InterPro IPR019831 Mn/Fe_SOD_N # InterPro IPR019832 Mn/Fe_SOD_C # InterPro IPR019833 Mn/Fe_SOD_BS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko04146 Peroxisome # KEGG_Pathway ko05016 Huntington's disease # Organism SODF_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11404 PTHR11404 # PATRIC 32118616 VBIEscCol129921_1728 # PDB 1ISA X-ray; 1.80 A; A/B=2-193 # PDB 1ISB X-ray; 1.85 A; A/B=2-193 # PDB 1ISC X-ray; 1.80 A; A/B=2-193 # PDB 1ZA5 X-ray; 1.80 A; A/B=2-193 # PDB 2BKB X-ray; 1.70 A; A/B/C/D=2-193 # PDB 2NYB X-ray; 1.10 A; A/B/C/D=2-193 # PIR A29940 DSECF # PIRSF PIRSF000349 SODismutase # PRINTS PR01703 MNSODISMTASE # PROSITE PS00088 SOD_MN # Pfam PF00081 Sod_Fe_N # Pfam PF02777 Sod_Fe_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SODF_ECOLI Superoxide dismutase [Fe] # RefSeq NP_416173 NC_000913.3 # RefSeq WP_000007283 NZ_LN832404.1 # SIMILARITY Belongs to the iron/manganese superoxide dismutase family. {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 6346322}. # SUPFAM SSF46609 SSF46609 # SUPFAM SSF54719 SSF54719 # eggNOG COG0605 LUCA # eggNOG ENOG4105CK4 Bacteria BLAST swissprot:SODF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SODF_ECOLI BioCyc ECOL316407:JW1648-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1648-MONOMER BioCyc EcoCyc:SUPEROX-DISMUTFE-MONOMER http://biocyc.org/getid?id=EcoCyc:SUPEROX-DISMUTFE-MONOMER BioCyc MetaCyc:SUPEROX-DISMUTFE-MONOMER http://biocyc.org/getid?id=MetaCyc:SUPEROX-DISMUTFE-MONOMER COG COG0605 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0605 DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1998.1726 http://dx.doi.org/10.1006/jmbi.1998.1726 DOI 10.1016/0014-5793(87)80357-5 http://dx.doi.org/10.1016/0014-5793(87)80357-5 DOI 10.1021/bi963047z http://dx.doi.org/10.1021/bi963047z DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.70.12.3725 http://dx.doi.org/10.1073/pnas.70.12.3725 DOI 10.1073/pnas.80.13.3884 http://dx.doi.org/10.1073/pnas.80.13.3884 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.15.1.1 http://www.genome.jp/dbget-bin/www_bget?EC:1.15.1.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J03511 http://www.ebi.ac.uk/ena/data/view/J03511 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.15.1.1 http://enzyme.expasy.org/EC/1.15.1.1 EchoBASE EB0947 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0947 EcoGene EG10954 http://www.ecogene.org/geneInfo.php?eg_id=EG10954 EnsemblBacteria AAC74728 http://www.ensemblgenomes.org/id/AAC74728 EnsemblBacteria AAC74728 http://www.ensemblgenomes.org/id/AAC74728 EnsemblBacteria BAA15422 http://www.ensemblgenomes.org/id/BAA15422 EnsemblBacteria BAA15422 http://www.ensemblgenomes.org/id/BAA15422 EnsemblBacteria BAA15422 http://www.ensemblgenomes.org/id/BAA15422 EnsemblBacteria b1656 http://www.ensemblgenomes.org/id/b1656 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0004784 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004784 GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_process GO:0000303 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000303 GO_process GO:0006801 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006801 GO_process GO:0019430 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019430 GO_process GO:0055114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 944953 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944953 HOGENOM HOG000013584 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000013584&db=HOGENOM6 InParanoid P0AGD3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGD3 IntAct P0AGD3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AGD3* IntEnz 1.15.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.15.1.1 InterPro IPR001189 http://www.ebi.ac.uk/interpro/entry/IPR001189 InterPro IPR019831 http://www.ebi.ac.uk/interpro/entry/IPR019831 InterPro IPR019832 http://www.ebi.ac.uk/interpro/entry/IPR019832 InterPro IPR019833 http://www.ebi.ac.uk/interpro/entry/IPR019833 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1648 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1648 KEGG_Gene eco:b1656 http://www.genome.jp/dbget-bin/www_bget?eco:b1656 KEGG_Orthology KO:K04564 http://www.genome.jp/dbget-bin/www_bget?KO:K04564 KEGG_Pathway ko04146 http://www.genome.jp/kegg-bin/show_pathway?ko04146 KEGG_Pathway ko05016 http://www.genome.jp/kegg-bin/show_pathway?ko05016 OMA DSLINWD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DSLINWD PANTHER PTHR11404 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11404 PDB 1ISA http://www.ebi.ac.uk/pdbe-srv/view/entry/1ISA PDB 1ISB http://www.ebi.ac.uk/pdbe-srv/view/entry/1ISB PDB 1ISC http://www.ebi.ac.uk/pdbe-srv/view/entry/1ISC PDB 1ZA5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZA5 PDB 2BKB http://www.ebi.ac.uk/pdbe-srv/view/entry/2BKB PDB 2NYB http://www.ebi.ac.uk/pdbe-srv/view/entry/2NYB PDBsum 1ISA http://www.ebi.ac.uk/pdbsum/1ISA PDBsum 1ISB http://www.ebi.ac.uk/pdbsum/1ISB PDBsum 1ISC http://www.ebi.ac.uk/pdbsum/1ISC PDBsum 1ZA5 http://www.ebi.ac.uk/pdbsum/1ZA5 PDBsum 2BKB http://www.ebi.ac.uk/pdbsum/2BKB PDBsum 2NYB http://www.ebi.ac.uk/pdbsum/2NYB PRINTS PR01703 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01703 PROSITE PS00088 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00088 PSORT swissprot:SODF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SODF_ECOLI PSORT-B swissprot:SODF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SODF_ECOLI PSORT2 swissprot:SODF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SODF_ECOLI Pfam PF00081 http://pfam.xfam.org/family/PF00081 Pfam PF02777 http://pfam.xfam.org/family/PF02777 Phobius swissprot:SODF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SODF_ECOLI PhylomeDB P0AGD3 http://phylomedb.org/?seqid=P0AGD3 ProteinModelPortal P0AGD3 http://www.proteinmodelportal.org/query/uniprot/P0AGD3 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 2447093 http://www.ncbi.nlm.nih.gov/pubmed/2447093 PubMed 3305077 http://www.ncbi.nlm.nih.gov/pubmed/3305077 PubMed 4590170 http://www.ncbi.nlm.nih.gov/pubmed/4590170 PubMed 6346322 http://www.ncbi.nlm.nih.gov/pubmed/6346322 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9125513 http://www.ncbi.nlm.nih.gov/pubmed/9125513 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 RefSeq NP_416173 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416173 RefSeq WP_000007283 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000007283 SMR P0AGD3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AGD3 STRING 511145.b1656 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1656&targetmode=cogs STRING COG0605 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0605&targetmode=cogs SUPFAM SSF46609 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46609 SUPFAM SSF54719 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54719 SWISS-2DPAGE P0AGD3 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AGD3 UniProtKB SODF_ECOLI http://www.uniprot.org/uniprot/SODF_ECOLI UniProtKB-AC P0AGD3 http://www.uniprot.org/uniprot/P0AGD3 charge swissprot:SODF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SODF_ECOLI eggNOG COG0605 http://eggnogapi.embl.de/nog_data/html/tree/COG0605 eggNOG ENOG4105CK4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CK4 epestfind swissprot:SODF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SODF_ECOLI garnier swissprot:SODF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SODF_ECOLI helixturnhelix swissprot:SODF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SODF_ECOLI hmoment swissprot:SODF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SODF_ECOLI iep swissprot:SODF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SODF_ECOLI inforesidue swissprot:SODF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SODF_ECOLI octanol swissprot:SODF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SODF_ECOLI pepcoil swissprot:SODF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SODF_ECOLI pepdigest swissprot:SODF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SODF_ECOLI pepinfo swissprot:SODF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SODF_ECOLI pepnet swissprot:SODF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SODF_ECOLI pepstats swissprot:SODF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SODF_ECOLI pepwheel swissprot:SODF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SODF_ECOLI pepwindow swissprot:SODF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SODF_ECOLI sigcleave swissprot:SODF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SODF_ECOLI ## Database ID URL or Descriptions # BioGrid 4260412 37 # EcoGene EG11892 sbmC # FUNCTION SBMC_ECOLI Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell. Protects cells against the natural plasmid-encoded toxins microcin B17 (MccB17) and CcdB, and synthetic quinolones. Can also protect cells against alkylating agents that act independently of DNA gyrase, suggesting a more general role in protecting cells against DNA damage. {ECO 0000269|PubMed 11850398, ECO 0000269|PubMed 13680098, ECO 0000269|PubMed 8709849, ECO 0000269|PubMed 9442027}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0008657 DNA topoisomerase (ATP-hydrolyzing) inhibitor activity; IDA:CACAO. # GO_function GO:0019899 enzyme binding; IPI:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:2000104 negative regulation of DNA-dependent DNA replication; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0019899 enzyme binding # GOslim_function GO:0030234 enzyme regulator activity # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # Gene3D 3.20.80.10 -; 1. # HAMAP MF_01896 DNA_gyrase_inhibitor # INDUCTION By DNA-damaging agents and by the entry of cells into the stationary growth phase. {ECO:0000269|PubMed 8709849}. # InterPro IPR010499 AraC_E-bd # InterPro IPR011256 Reg_factor_effector_dom # InterPro IPR024911 DNA_gyrase_inhibitor_GyrI # InterPro IPR029442 GyrI-like # Organism SBMC_ECOLI Escherichia coli (strain K12) # PATRIC 32119353 VBIEscCol129921_2086 # PDB 1JYH X-ray; 1.80 A; A=1-157 # PIR H64965 H64965 # Pfam PF06445 GyrI-like # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SBMC_ECOLI DNA gyrase inhibitor # RefSeq NP_416513 NC_000913.3 # RefSeq WP_001105415 NZ_LN832404.1 # SIMILARITY Belongs to the DNA gyrase inhibitor family. {ECO 0000305}. # SMART SM00871 AraC_E_bind # SUBCELLULAR LOCATION SBMC_ECOLI Cytoplasm. # SUBUNIT Interacts with DNA gyrase. Interacts preferentially with the holoenzyme composed of GyrA and GyrB, but can also weakly interact with the individual GyrA and GyrB subunits. {ECO:0000269|PubMed 11777918}. # SUPFAM SSF55136 SSF55136 # eggNOG COG3449 LUCA # eggNOG ENOG4108S5C Bacteria BLAST swissprot:SBMC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SBMC_ECOLI BioCyc ECOL316407:JW1991-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1991-MONOMER BioCyc EcoCyc:EG11892-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11892-MONOMER COG COG3449 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3449 DIP DIP-9862N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9862N DOI 10.1002/prot.10102 http://dx.doi.org/10.1002/prot.10102 DOI 10.1007/s00203-003-0598-4 http://dx.doi.org/10.1007/s00203-003-0598-4 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.273.4.1933 http://dx.doi.org/10.1074/jbc.273.4.1933 DOI 10.1074/jbc.M111278200 http://dx.doi.org/10.1074/jbc.M111278200 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/embo-reports/kvf038 http://dx.doi.org/10.1093/embo-reports/kvf038 DOI 10.1111/j.1365-2958.1995.mmi_18020301.x http://dx.doi.org/10.1111/j.1365-2958.1995.mmi_18020301.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00009 http://www.ebi.ac.uk/ena/data/view/U00009 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X84885 http://www.ebi.ac.uk/ena/data/view/X84885 EchoBASE EB1838 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1838 EcoGene EG11892 http://www.ecogene.org/geneInfo.php?eg_id=EG11892 EnsemblBacteria AAC75070 http://www.ensemblgenomes.org/id/AAC75070 EnsemblBacteria AAC75070 http://www.ensemblgenomes.org/id/AAC75070 EnsemblBacteria BAA15830 http://www.ensemblgenomes.org/id/BAA15830 EnsemblBacteria BAA15830 http://www.ensemblgenomes.org/id/BAA15830 EnsemblBacteria BAA15830 http://www.ensemblgenomes.org/id/BAA15830 EnsemblBacteria b2009 http://www.ensemblgenomes.org/id/b2009 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0008657 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008657 GO_function GO:0019899 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:2000104 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000104 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0019899 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899 GOslim_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.20.80.10 http://www.cathdb.info/version/latest/superfamily/3.20.80.10 GeneID 946546 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946546 HAMAP MF_01896 http://hamap.expasy.org/unirule/MF_01896 HOGENOM HOG000121896 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000121896&db=HOGENOM6 InParanoid P33012 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33012 IntAct P33012 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33012* InterPro IPR010499 http://www.ebi.ac.uk/interpro/entry/IPR010499 InterPro IPR011256 http://www.ebi.ac.uk/interpro/entry/IPR011256 InterPro IPR024911 http://www.ebi.ac.uk/interpro/entry/IPR024911 InterPro IPR029442 http://www.ebi.ac.uk/interpro/entry/IPR029442 KEGG_Gene ecj:JW1991 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1991 KEGG_Gene eco:b2009 http://www.genome.jp/dbget-bin/www_bget?eco:b2009 KEGG_Orthology KO:K07470 http://www.genome.jp/dbget-bin/www_bget?KO:K07470 MINT MINT-226165 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-226165 OMA TPWYQFF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TPWYQFF PDB 1JYH http://www.ebi.ac.uk/pdbe-srv/view/entry/1JYH PDBsum 1JYH http://www.ebi.ac.uk/pdbsum/1JYH PSORT swissprot:SBMC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SBMC_ECOLI PSORT-B swissprot:SBMC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SBMC_ECOLI PSORT2 swissprot:SBMC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SBMC_ECOLI Pfam PF06445 http://pfam.xfam.org/family/PF06445 Phobius swissprot:SBMC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SBMC_ECOLI ProteinModelPortal P33012 http://www.proteinmodelportal.org/query/uniprot/P33012 PubMed 11777918 http://www.ncbi.nlm.nih.gov/pubmed/11777918 PubMed 11850398 http://www.ncbi.nlm.nih.gov/pubmed/11850398 PubMed 11948793 http://www.ncbi.nlm.nih.gov/pubmed/11948793 PubMed 13680098 http://www.ncbi.nlm.nih.gov/pubmed/13680098 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8709849 http://www.ncbi.nlm.nih.gov/pubmed/8709849 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9442027 http://www.ncbi.nlm.nih.gov/pubmed/9442027 RefSeq NP_416513 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416513 RefSeq WP_001105415 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001105415 SMART SM00871 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00871 SMR P33012 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33012 STRING 511145.b2009 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2009&targetmode=cogs STRING COG3449 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3449&targetmode=cogs SUPFAM SSF55136 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55136 UniProtKB SBMC_ECOLI http://www.uniprot.org/uniprot/SBMC_ECOLI UniProtKB-AC P33012 http://www.uniprot.org/uniprot/P33012 charge swissprot:SBMC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SBMC_ECOLI eggNOG COG3449 http://eggnogapi.embl.de/nog_data/html/tree/COG3449 eggNOG ENOG4108S5C http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108S5C epestfind swissprot:SBMC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SBMC_ECOLI garnier swissprot:SBMC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SBMC_ECOLI helixturnhelix swissprot:SBMC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SBMC_ECOLI hmoment swissprot:SBMC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SBMC_ECOLI iep swissprot:SBMC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SBMC_ECOLI inforesidue swissprot:SBMC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SBMC_ECOLI octanol swissprot:SBMC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SBMC_ECOLI pepcoil swissprot:SBMC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SBMC_ECOLI pepdigest swissprot:SBMC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SBMC_ECOLI pepinfo swissprot:SBMC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SBMC_ECOLI pepnet swissprot:SBMC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SBMC_ECOLI pepstats swissprot:SBMC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SBMC_ECOLI pepwheel swissprot:SBMC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SBMC_ECOLI pepwindow swissprot:SBMC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SBMC_ECOLI sigcleave swissprot:SBMC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SBMC_ECOLI ## Database ID URL or Descriptions # AltName INSA5_ECOLI IS1h # CAUTION There is no equivalent of this gene in strain K12 / W3110. {ECO 0000305}. # EcoGene EG40001 insA5 # FUNCTION INSA5_ECOLI Absolutely required for transposition of IS1. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 1.10.10.60 -; 1. # InterPro IPR003220 InsA_N_dom # InterPro IPR009057 Homeodomain-like # InterPro IPR024431 InsA_HTH_dom # Organism INSA5_ECOLI Escherichia coli (strain K12) # Pfam PF03811 Zn_Tnp_IS1 # Pfam PF12759 HTH_Tnp_IS1 # Proteomes UP000000625 Chromosome # RecName INSA5_ECOLI Insertion element IS1 5 protein InsA # RefSeq NP_414563 NC_000913.3 # RefSeq NP_416408 NC_000913.3 # RefSeq NP_417901 NC_000913.3 # RefSeq WP_000179213 NZ_LN832404.1 # SIMILARITY Belongs to the IS1 elements InsA family. {ECO 0000305}. # eggNOG COG3677 LUCA BLAST swissprot:INSA5_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSA5_ECOLI BioCyc EcoCyc:MONOMER0-4225 http://biocyc.org/getid?id=EcoCyc:MONOMER0-4225 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4757 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4757 EcoGene EG40001 http://www.ecogene.org/geneInfo.php?eg_id=EG40001 EnsemblBacteria AAC74964 http://www.ensemblgenomes.org/id/AAC74964 EnsemblBacteria AAC74964 http://www.ensemblgenomes.org/id/AAC74964 EnsemblBacteria b1894 http://www.ensemblgenomes.org/id/b1894 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 GeneID 24901758 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24901758 GeneID 945800 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945800 GeneID 947950 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947950 GeneID 948449 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948449 InParanoid P0CF11 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CF11 InterPro IPR003220 http://www.ebi.ac.uk/interpro/entry/IPR003220 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR024431 http://www.ebi.ac.uk/interpro/entry/IPR024431 KEGG_Gene eco:b0022 http://www.genome.jp/dbget-bin/www_bget?eco:b0022 KEGG_Gene eco:b1894 http://www.genome.jp/dbget-bin/www_bget?eco:b1894 KEGG_Gene eco:b3444 http://www.genome.jp/dbget-bin/www_bget?eco:b3444 PSORT swissprot:INSA5_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSA5_ECOLI PSORT-B swissprot:INSA5_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSA5_ECOLI PSORT2 swissprot:INSA5_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSA5_ECOLI Pfam PF03811 http://pfam.xfam.org/family/PF03811 Pfam PF12759 http://pfam.xfam.org/family/PF12759 Phobius swissprot:INSA5_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSA5_ECOLI PhylomeDB P0CF11 http://phylomedb.org/?seqid=P0CF11 ProteinModelPortal P0CF11 http://www.proteinmodelportal.org/query/uniprot/P0CF11 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414563 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414563 RefSeq NP_416408 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416408 RefSeq NP_417901 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417901 RefSeq WP_000179213 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000179213 STRING 511145.b3444 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3444&targetmode=cogs UniProtKB INSA5_ECOLI http://www.uniprot.org/uniprot/INSA5_ECOLI UniProtKB-AC P0CF11 http://www.uniprot.org/uniprot/P0CF11 charge swissprot:INSA5_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSA5_ECOLI eggNOG COG3677 http://eggnogapi.embl.de/nog_data/html/tree/COG3677 epestfind swissprot:INSA5_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSA5_ECOLI garnier swissprot:INSA5_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSA5_ECOLI helixturnhelix swissprot:INSA5_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSA5_ECOLI hmoment swissprot:INSA5_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSA5_ECOLI iep swissprot:INSA5_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSA5_ECOLI inforesidue swissprot:INSA5_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSA5_ECOLI octanol swissprot:INSA5_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSA5_ECOLI pepcoil swissprot:INSA5_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSA5_ECOLI pepdigest swissprot:INSA5_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSA5_ECOLI pepinfo swissprot:INSA5_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSA5_ECOLI pepnet swissprot:INSA5_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSA5_ECOLI pepstats swissprot:INSA5_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSA5_ECOLI pepwheel swissprot:INSA5_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSA5_ECOLI pepwindow swissprot:INSA5_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSA5_ECOLI sigcleave swissprot:INSA5_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSA5_ECOLI ## Database ID URL or Descriptions # BioGrid 4262267 14 # EcoGene EG13288 ygaP # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_function GO:0004792 thiosulfate sulfurtransferase activity; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # Gene3D 3.40.250.10 -; 1. # IntAct P55734 4 # InterPro IPR001763 Rhodanese-like_dom # InterPro IPR021309 DUF2892 # Organism YGAP_ECOLI Escherichia coli (strain K12) # PATRIC 32120726 VBIEscCol129921_2760 # PDB 2MOI NMR; -; A=2-109 # PDB 2MOL NMR; -; A=2-109 # PDB 2MPN NMR; -; A/B=107-174 # PDB 5HBL X-ray; 1.62 A; A=2-109 # PDB 5HBO X-ray; 1.66 A; A=2-109 # PDB 5HBP X-ray; 1.50 A; A=2-109 # PDB 5HBQ X-ray; 1.66 A; A=2-109 # PDB 5LAM NMR; -; A=2-109 # PDB 5LAO NMR; -; A=2-109 # PIR E65046 E65046 # PROSITE PS50206 RHODANESE_3 # Pfam PF00581 Rhodanese # Pfam PF11127 DUF2892 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGAP_ECOLI Inner membrane protein YgaP # RefSeq NP_417154 NC_000913.3 # RefSeq WP_001229442 NZ_LN832404.1 # SIMILARITY Contains 1 rhodanese domain. {ECO:0000255|PROSITE- ProRule PRU00173}. # SIMILARITY To Synechocystis PCC 6803 slr1261. {ECO 0000305}. # SMART SM00450 RHOD # SUBCELLULAR LOCATION YGAP_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF52821 SSF52821 # eggNOG COG0607 LUCA # eggNOG ENOG4108V62 Bacteria BLAST swissprot:YGAP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGAP_ECOLI BioCyc ECOL316407:JW2643-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2643-MONOMER BioCyc EcoCyc:G7398-MONOMER http://biocyc.org/getid?id=EcoCyc:G7398-MONOMER BioCyc MetaCyc:G7398-MONOMER http://biocyc.org/getid?id=MetaCyc:G7398-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/20.24.6735 http://dx.doi.org/10.1093/nar/20.24.6735 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X69210 http://www.ebi.ac.uk/ena/data/view/X69210 EchoBASE EB3073 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3073 EcoGene EG13288 http://www.ecogene.org/geneInfo.php?eg_id=EG13288 EnsemblBacteria AAC75715 http://www.ensemblgenomes.org/id/AAC75715 EnsemblBacteria AAC75715 http://www.ensemblgenomes.org/id/AAC75715 EnsemblBacteria BAE76780 http://www.ensemblgenomes.org/id/BAE76780 EnsemblBacteria BAE76780 http://www.ensemblgenomes.org/id/BAE76780 EnsemblBacteria BAE76780 http://www.ensemblgenomes.org/id/BAE76780 EnsemblBacteria b2668 http://www.ensemblgenomes.org/id/b2668 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0004792 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004792 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 Gene3D 3.40.250.10 http://www.cathdb.info/version/latest/superfamily/3.40.250.10 GeneID 947135 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947135 HOGENOM HOG000252161 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000252161&db=HOGENOM6 InParanoid P55734 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P55734 IntAct P55734 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P55734* InterPro IPR001763 http://www.ebi.ac.uk/interpro/entry/IPR001763 InterPro IPR021309 http://www.ebi.ac.uk/interpro/entry/IPR021309 KEGG_Gene ecj:JW2643 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2643 KEGG_Gene eco:b2668 http://www.genome.jp/dbget-bin/www_bget?eco:b2668 OMA YAREHIP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YAREHIP PDB 2MOI http://www.ebi.ac.uk/pdbe-srv/view/entry/2MOI PDB 2MOL http://www.ebi.ac.uk/pdbe-srv/view/entry/2MOL PDB 2MPN http://www.ebi.ac.uk/pdbe-srv/view/entry/2MPN PDB 5HBL http://www.ebi.ac.uk/pdbe-srv/view/entry/5HBL PDB 5HBO http://www.ebi.ac.uk/pdbe-srv/view/entry/5HBO PDB 5HBP http://www.ebi.ac.uk/pdbe-srv/view/entry/5HBP PDB 5HBQ http://www.ebi.ac.uk/pdbe-srv/view/entry/5HBQ PDB 5LAM http://www.ebi.ac.uk/pdbe-srv/view/entry/5LAM PDB 5LAO http://www.ebi.ac.uk/pdbe-srv/view/entry/5LAO PDBsum 2MOI http://www.ebi.ac.uk/pdbsum/2MOI PDBsum 2MOL http://www.ebi.ac.uk/pdbsum/2MOL PDBsum 2MPN http://www.ebi.ac.uk/pdbsum/2MPN PDBsum 5HBL http://www.ebi.ac.uk/pdbsum/5HBL PDBsum 5HBO http://www.ebi.ac.uk/pdbsum/5HBO PDBsum 5HBP http://www.ebi.ac.uk/pdbsum/5HBP PDBsum 5HBQ http://www.ebi.ac.uk/pdbsum/5HBQ PDBsum 5LAM http://www.ebi.ac.uk/pdbsum/5LAM PDBsum 5LAO http://www.ebi.ac.uk/pdbsum/5LAO PROSITE PS50206 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50206 PSORT swissprot:YGAP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGAP_ECOLI PSORT-B swissprot:YGAP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGAP_ECOLI PSORT2 swissprot:YGAP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGAP_ECOLI Pfam PF00581 http://pfam.xfam.org/family/PF00581 Pfam PF11127 http://pfam.xfam.org/family/PF11127 Phobius swissprot:YGAP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGAP_ECOLI PhylomeDB P55734 http://phylomedb.org/?seqid=P55734 ProteinModelPortal P55734 http://www.proteinmodelportal.org/query/uniprot/P55734 PubMed 1480493 http://www.ncbi.nlm.nih.gov/pubmed/1480493 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417154 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417154 RefSeq WP_001229442 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001229442 SMART SM00450 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00450 SMR P55734 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P55734 STRING 511145.b2668 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2668&targetmode=cogs SUPFAM SSF52821 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52821 UniProtKB YGAP_ECOLI http://www.uniprot.org/uniprot/YGAP_ECOLI UniProtKB-AC P55734 http://www.uniprot.org/uniprot/P55734 charge swissprot:YGAP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGAP_ECOLI eggNOG COG0607 http://eggnogapi.embl.de/nog_data/html/tree/COG0607 eggNOG ENOG4108V62 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108V62 epestfind swissprot:YGAP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGAP_ECOLI garnier swissprot:YGAP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGAP_ECOLI helixturnhelix swissprot:YGAP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGAP_ECOLI hmoment swissprot:YGAP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGAP_ECOLI iep swissprot:YGAP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGAP_ECOLI inforesidue swissprot:YGAP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGAP_ECOLI octanol swissprot:YGAP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGAP_ECOLI pepcoil swissprot:YGAP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGAP_ECOLI pepdigest swissprot:YGAP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGAP_ECOLI pepinfo swissprot:YGAP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGAP_ECOLI pepnet swissprot:YGAP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGAP_ECOLI pepstats swissprot:YGAP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGAP_ECOLI pepwheel swissprot:YGAP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGAP_ECOLI pepwindow swissprot:YGAP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGAP_ECOLI sigcleave swissprot:YGAP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGAP_ECOLI ## Database ID URL or Descriptions # BioGrid 4259445 8 # EcoGene EG14289 ymgA # FUNCTION YMGA_ECOLI Probably a connector protein for RcsB/C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. May serve to stimulate biofilm maturation, probably via the Rcs phosphorelay. Mild overexpression at 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB. # GO_process GO:1900191 negative regulation of single-species biofilm formation; IMP:EcoCyc. # GOslim_process GO:0008150 biological_process # INDUCTION YMGA_ECOLI Induced by 5-fluorouracil. Strongly induced at 16 degrees Celsius. Expression is dependent on RpoS, repressed by YcgE. At 16 degrees Celsius with blue light irradiation, expression of this operon is absolutely dependent on YcgF for relief from YcgE repression. Part of the ycgZ-ymgA-ariR-ymgC operon. {ECO 0000269|PubMed 18174134, ECO 0000269|PubMed 19172264, ECO 0000269|PubMed 19240136}. # IntAct P75992 18 # Organism YMGA_ECOLI Escherichia coli (strain K12) # PIR B64862 B64862 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YMGA_ECOLI Probable two-component-system connector protein YmgA # RefSeq NP_415683 NC_000913.3 # RefSeq WP_000858002 NZ_LN832404.1 # eggNOG ENOG41077SS Bacteria # eggNOG ENOG410ZBUB LUCA BLAST swissprot:YMGA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YMGA_ECOLI BioCyc ECOL316407:JW1152-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1152-MONOMER BioCyc EcoCyc:G6605-MONOMER http://biocyc.org/getid?id=EcoCyc:G6605-MONOMER DOI 10.1007/s00253-009-1860-8 http://dx.doi.org/10.1007/s00253-009-1860-8 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1099/mic.0.2007/012021-0 http://dx.doi.org/10.1099/mic.0.2007/012021-0 DOI 10.1101/gad.499409 http://dx.doi.org/10.1101/gad.499409 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4037 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4037 EcoGene EG14289 http://www.ecogene.org/geneInfo.php?eg_id=EG14289 EnsemblBacteria AAC74249 http://www.ensemblgenomes.org/id/AAC74249 EnsemblBacteria AAC74249 http://www.ensemblgenomes.org/id/AAC74249 EnsemblBacteria BAE76386 http://www.ensemblgenomes.org/id/BAE76386 EnsemblBacteria BAE76386 http://www.ensemblgenomes.org/id/BAE76386 EnsemblBacteria BAE76386 http://www.ensemblgenomes.org/id/BAE76386 EnsemblBacteria b1165 http://www.ensemblgenomes.org/id/b1165 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:1900191 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1900191 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 948991 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948991 HOGENOM HOG000119668 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000119668&db=HOGENOM6 IntAct P75992 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75992* KEGG_Gene ecj:JW1152 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1152 KEGG_Gene eco:b1165 http://www.genome.jp/dbget-bin/www_bget?eco:b1165 OMA HILRMKI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HILRMKI PSORT swissprot:YMGA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YMGA_ECOLI PSORT-B swissprot:YMGA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YMGA_ECOLI PSORT2 swissprot:YMGA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YMGA_ECOLI Phobius swissprot:YMGA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YMGA_ECOLI ProteinModelPortal P75992 http://www.proteinmodelportal.org/query/uniprot/P75992 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18174134 http://www.ncbi.nlm.nih.gov/pubmed/18174134 PubMed 19172264 http://www.ncbi.nlm.nih.gov/pubmed/19172264 PubMed 19240136 http://www.ncbi.nlm.nih.gov/pubmed/19240136 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415683 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415683 RefSeq WP_000858002 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000858002 STRING 511145.b1165 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1165&targetmode=cogs UniProtKB YMGA_ECOLI http://www.uniprot.org/uniprot/YMGA_ECOLI UniProtKB-AC P75992 http://www.uniprot.org/uniprot/P75992 charge swissprot:YMGA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YMGA_ECOLI eggNOG ENOG41077SS http://eggnogapi.embl.de/nog_data/html/tree/ENOG41077SS eggNOG ENOG410ZBUB http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZBUB epestfind swissprot:YMGA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YMGA_ECOLI garnier swissprot:YMGA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YMGA_ECOLI helixturnhelix swissprot:YMGA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YMGA_ECOLI hmoment swissprot:YMGA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YMGA_ECOLI iep swissprot:YMGA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YMGA_ECOLI inforesidue swissprot:YMGA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YMGA_ECOLI octanol swissprot:YMGA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YMGA_ECOLI pepcoil swissprot:YMGA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YMGA_ECOLI pepdigest swissprot:YMGA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YMGA_ECOLI pepinfo swissprot:YMGA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YMGA_ECOLI pepnet swissprot:YMGA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YMGA_ECOLI pepstats swissprot:YMGA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YMGA_ECOLI pepwheel swissprot:YMGA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YMGA_ECOLI pepwindow swissprot:YMGA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YMGA_ECOLI sigcleave swissprot:YMGA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YMGA_ECOLI ## Database ID URL or Descriptions # EcoGene EG13837 gnsB # FUNCTION GNSB_ECOLI Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation. {ECO 0000269|PubMed 11544213}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_process GO:0006636 unsaturated fatty acid biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # InterPro IPR012563 Gns # Organism GNSB_ECOLI Escherichia coli (strain K12) # PATRIC 32118404 VBIEscCol129921_1622 # PIR A64910 A64910 # Pfam PF08178 GnsAB_toxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GNSB_ECOLI Protein GnsB # RefSeq NP_416068 NC_000913.3 # RefSeq WP_001019606 NZ_LN832404.1 # SIMILARITY Belongs to the gns family. {ECO 0000305}. # eggNOG ENOG4106H71 Bacteria # eggNOG ENOG410Y8R8 LUCA BLAST swissprot:GNSB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GNSB_ECOLI BioCyc ECOL316407:JW5253-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5253-MONOMER BioCyc EcoCyc:G6823-MONOMER http://biocyc.org/getid?id=EcoCyc:G6823-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.183.19.5523-5528.2001 http://dx.doi.org/10.1128/JB.183.19.5523-5528.2001 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3598 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3598 EcoGene EG13837 http://www.ecogene.org/geneInfo.php?eg_id=EG13837 EnsemblBacteria AAC74623 http://www.ensemblgenomes.org/id/AAC74623 EnsemblBacteria AAC74623 http://www.ensemblgenomes.org/id/AAC74623 EnsemblBacteria BAA15253 http://www.ensemblgenomes.org/id/BAA15253 EnsemblBacteria BAA15253 http://www.ensemblgenomes.org/id/BAA15253 EnsemblBacteria BAA15253 http://www.ensemblgenomes.org/id/BAA15253 EnsemblBacteria b1550 http://www.ensemblgenomes.org/id/b1550 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_process GO:0006636 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006636 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 946054 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946054 HOGENOM HOG000268050 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000268050&db=HOGENOM6 IntAct P77695 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77695* InterPro IPR012563 http://www.ebi.ac.uk/interpro/entry/IPR012563 KEGG_Gene ecj:JW5253 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5253 KEGG_Gene eco:b1550 http://www.genome.jp/dbget-bin/www_bget?eco:b1550 OMA TVYQESH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TVYQESH PSORT swissprot:GNSB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GNSB_ECOLI PSORT-B swissprot:GNSB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GNSB_ECOLI PSORT2 swissprot:GNSB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GNSB_ECOLI Pfam PF08178 http://pfam.xfam.org/family/PF08178 Phobius swissprot:GNSB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GNSB_ECOLI ProteinModelPortal P77695 http://www.proteinmodelportal.org/query/uniprot/P77695 PubMed 11544213 http://www.ncbi.nlm.nih.gov/pubmed/11544213 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416068 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416068 RefSeq WP_001019606 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001019606 SMR P77695 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77695 STRING 511145.b1550 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1550&targetmode=cogs UniProtKB GNSB_ECOLI http://www.uniprot.org/uniprot/GNSB_ECOLI UniProtKB-AC P77695 http://www.uniprot.org/uniprot/P77695 charge swissprot:GNSB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GNSB_ECOLI eggNOG ENOG4106H71 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106H71 eggNOG ENOG410Y8R8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y8R8 epestfind swissprot:GNSB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GNSB_ECOLI garnier swissprot:GNSB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GNSB_ECOLI helixturnhelix swissprot:GNSB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GNSB_ECOLI hmoment swissprot:GNSB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GNSB_ECOLI iep swissprot:GNSB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GNSB_ECOLI inforesidue swissprot:GNSB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GNSB_ECOLI octanol swissprot:GNSB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GNSB_ECOLI pepcoil swissprot:GNSB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GNSB_ECOLI pepdigest swissprot:GNSB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GNSB_ECOLI pepinfo swissprot:GNSB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GNSB_ECOLI pepnet swissprot:GNSB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GNSB_ECOLI pepstats swissprot:GNSB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GNSB_ECOLI pepwheel swissprot:GNSB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GNSB_ECOLI pepwindow swissprot:GNSB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GNSB_ECOLI sigcleave swissprot:GNSB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GNSB_ECOLI ## Database ID URL or Descriptions # BioGrid 4261851 3 # CATALYTIC ACTIVITY ATP + H(2)O + monosaccharide(Out) = ADP + phosphate + monosaccharide(In). {ECO:0000255|HAMAP-Rule MF_01721}. # EcoGene EG10058 araG # FUNCTION ARAG_ECOLI Part of the ABC transporter complex AraFGH involved in arabinose import. Responsible for energy coupling to the transport system (Probable). {ECO 0000305|PubMed 2656640, ECO 0000305|PubMed 7028715}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0015407 monosaccharide-transporting ATPase activity; IEA:UniProtKB-EC. # GO_function GO:0016887 ATPase activity; ISM:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.300 -; 2. # IntAct P0AAF3 7 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00213 L-Arabinose transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism ARAG_ECOLI Escherichia coli (strain K12) # PATRIC 32119125 VBIEscCol129921_1980 # PIR S01074 S01074 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2; 2 # PROSITE PS51268 ARAG # Pfam PF00005 ABC_tran; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Arabinose import ATP-binding protein AraG {ECO:0000255|HAMAP-Rule MF_01721} # RefSeq NP_416413 NC_000913.3 # RefSeq WP_001187819 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. Arabinose importer (TC 3.A.1.2.2) family. {ECO:0000255|HAMAP-Rule MF_01721}. # SIMILARITY Contains 2 ABC transporter domains. {ECO:0000255|HAMAP-Rule MF_01721}. # SMART SM00382 AAA; 2 # SUBCELLULAR LOCATION ARAG_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01721, ECO 0000269|PubMed 7028715}; Peripheral membrane protein {ECO 0000255|HAMAP-Rule MF_01721, ECO 0000269|PubMed 7028715}. # SUBUNIT The complex is composed of two ATP-binding proteins (AraG), two transmembrane proteins (AraH) and a solute-binding protein (AraF). {ECO:0000255|HAMAP-Rule MF_01721}. # SUPFAM SSF52540 SSF52540; 2 # TCDB 3.A.1.2 the atp-binding cassette (abc) superfamily # eggNOG COG1129 LUCA # eggNOG ENOG4105C2J Bacteria BLAST swissprot:ARAG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARAG_ECOLI BioCyc ECOL316407:JW1888-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1888-MONOMER BioCyc EcoCyc:ARAG-MONOMER http://biocyc.org/getid?id=EcoCyc:ARAG-MONOMER BioCyc MetaCyc:ARAG-MONOMER http://biocyc.org/getid?id=MetaCyc:ARAG-MONOMER COG COG1129 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1129 DIP DIP-48055N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48055N DOI 10.1016/0022-2836(87)90607-3 http://dx.doi.org/10.1016/0022-2836(87)90607-3 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.3.17 {ECO:0000255|HAMAP-Rule:MF_01721} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.17 {ECO:0000255|HAMAP-Rule:MF_01721} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X06091 http://www.ebi.ac.uk/ena/data/view/X06091 ENZYME 3.6.3.17 {ECO:0000255|HAMAP-Rule:MF_01721} http://enzyme.expasy.org/EC/3.6.3.17 {ECO:0000255|HAMAP-Rule:MF_01721} EchoBASE EB0056 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0056 EcoGene EG10058 http://www.ecogene.org/geneInfo.php?eg_id=EG10058 EnsemblBacteria AAC74970 http://www.ensemblgenomes.org/id/AAC74970 EnsemblBacteria AAC74970 http://www.ensemblgenomes.org/id/AAC74970 EnsemblBacteria BAA15720 http://www.ensemblgenomes.org/id/BAA15720 EnsemblBacteria BAA15720 http://www.ensemblgenomes.org/id/BAA15720 EnsemblBacteria BAA15720 http://www.ensemblgenomes.org/id/BAA15720 EnsemblBacteria b1900 http://www.ensemblgenomes.org/id/b1900 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0015407 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015407 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 946408 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946408 InParanoid P0AAF3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAF3 IntAct P0AAF3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAF3* IntEnz 3.6.3.17 {ECO:0000255|HAMAP-Rule:MF_01721} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.17 {ECO:0000255|HAMAP-Rule:MF_01721} InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1888 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1888 KEGG_Gene eco:b1900 http://www.genome.jp/dbget-bin/www_bget?eco:b1900 KEGG_Orthology KO:K10539 http://www.genome.jp/dbget-bin/www_bget?KO:K10539 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 MINT MINT-1305954 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1305954 OMA AKHEIYH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AKHEIYH PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PROSITE PS51268 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51268 PSORT swissprot:ARAG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARAG_ECOLI PSORT-B swissprot:ARAG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARAG_ECOLI PSORT2 swissprot:ARAG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARAG_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Phobius swissprot:ARAG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARAG_ECOLI PhylomeDB P0AAF3 http://phylomedb.org/?seqid=P0AAF3 ProteinModelPortal P0AAF3 http://www.proteinmodelportal.org/query/uniprot/P0AAF3 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2445996 http://www.ncbi.nlm.nih.gov/pubmed/2445996 PubMed 2656640 http://www.ncbi.nlm.nih.gov/pubmed/2656640 PubMed 7028715 http://www.ncbi.nlm.nih.gov/pubmed/7028715 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416413 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416413 RefSeq WP_001187819 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001187819 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P0AAF3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAF3 STRING 511145.b1900 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1900&targetmode=cogs STRING COG1129 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1129&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.2 http://www.tcdb.org/search/result.php?tc=3.A.1.2 UniProtKB ARAG_ECOLI http://www.uniprot.org/uniprot/ARAG_ECOLI UniProtKB-AC P0AAF3 http://www.uniprot.org/uniprot/P0AAF3 charge swissprot:ARAG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARAG_ECOLI eggNOG COG1129 http://eggnogapi.embl.de/nog_data/html/tree/COG1129 eggNOG ENOG4105C2J http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C2J epestfind swissprot:ARAG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARAG_ECOLI garnier swissprot:ARAG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARAG_ECOLI helixturnhelix swissprot:ARAG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARAG_ECOLI hmoment swissprot:ARAG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARAG_ECOLI iep swissprot:ARAG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARAG_ECOLI inforesidue swissprot:ARAG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARAG_ECOLI octanol swissprot:ARAG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARAG_ECOLI pepcoil swissprot:ARAG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARAG_ECOLI pepdigest swissprot:ARAG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARAG_ECOLI pepinfo swissprot:ARAG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARAG_ECOLI pepnet swissprot:ARAG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARAG_ECOLI pepstats swissprot:ARAG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARAG_ECOLI pepwheel swissprot:ARAG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARAG_ECOLI pepwindow swissprot:ARAG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARAG_ECOLI sigcleave swissprot:ARAG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARAG_ECOLI ## Database ID URL or Descriptions # GO_component GO:0016020 membrane; IEA:UniProtKB-SubCell. # GOslim_component GO:0005575 cellular_component # Organism YUAE_ECOLI Escherichia coli (strain K12) # PROSITE PS51257 PROKAR_LIPOPROTEIN # RecName YUAE_ECOLI Uncharacterized protein YuaE # RefSeq NP_061393 NC_002483.1 # RefSeq WP_000483319 NZ_CP014273.1 # SUBCELLULAR LOCATION YUAE_ECOLI Membrane {ECO 0000305}; Lipid-anchor {ECO 0000255|PROSITE-ProRule PRU00303}. BLAST swissprot:YUAE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YUAE_ECOLI EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GeneID 1263519 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263519 OMA EMFALEL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EMFALEL PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YUAE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YUAE_ECOLI PSORT-B swissprot:YUAE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YUAE_ECOLI PSORT2 swissprot:YUAE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YUAE_ECOLI Phobius swissprot:YUAE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YUAE_ECOLI ProteinModelPortal Q9JMT5 http://www.proteinmodelportal.org/query/uniprot/Q9JMT5 RefSeq NP_061393 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061393 RefSeq WP_000483319 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000483319 SMR Q9JMT5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9JMT5 UniProtKB YUAE_ECOLI http://www.uniprot.org/uniprot/YUAE_ECOLI UniProtKB-AC Q9JMT5 http://www.uniprot.org/uniprot/Q9JMT5 charge swissprot:YUAE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YUAE_ECOLI epestfind swissprot:YUAE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YUAE_ECOLI garnier swissprot:YUAE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YUAE_ECOLI helixturnhelix swissprot:YUAE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YUAE_ECOLI hmoment swissprot:YUAE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YUAE_ECOLI iep swissprot:YUAE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YUAE_ECOLI inforesidue swissprot:YUAE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YUAE_ECOLI octanol swissprot:YUAE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YUAE_ECOLI pepcoil swissprot:YUAE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YUAE_ECOLI pepdigest swissprot:YUAE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YUAE_ECOLI pepinfo swissprot:YUAE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YUAE_ECOLI pepnet swissprot:YUAE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YUAE_ECOLI pepstats swissprot:YUAE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YUAE_ECOLI pepwheel swissprot:YUAE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YUAE_ECOLI pepwindow swissprot:YUAE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YUAE_ECOLI sigcleave swissprot:YUAE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YUAE_ECOLI ## Database ID URL or Descriptions # AltName MLTB_ECOLI 35 kDa soluble lytic transglycosylase # AltName MLTB_ECOLI Murein hydrolase B # AltName MLTB_ECOLI Slt35 # BioGrid 4262079 357 # CATALYTIC ACTIVITY MLTB_ECOLI Exolytic cleavage of the (1->4)-beta- glycosidic linkage between N-acetylmuramic acid (MurNAc) and N- acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue. # CAZy GH103 Glycoside Hydrolase Family 103 # EcoGene EG12699 mltB # FUNCTION MLTB_ECOLI Murein-degrading enzyme. Catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N- acetylglucosamine residues in peptidoglycan. May play a role in recycling of muropeptides during cell elongation and/or cell division. # GO_component GO:0009279 cell outer membrane; IEA:UniProtKB-SubCell. # GO_function GO:0008933 lytic transglycosylase activity; IMP:EcoCyc. # GO_function GO:0052762 gellan lyase activity; IEA:UniProtKB-EC. # GO_function GO:0052764 exo-oligoalginate lyase activity; IEA:UniProtKB-EC. # GO_process GO:0009252 peptidoglycan biosynthetic process; IMP:EcoCyc. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0071554 cell wall organization or biogenesis # IntAct P41052 10 # InterPro IPR011757 Lytic_transglycosylase_MltB # InterPro IPR023346 Lysozyme-like_dom # InterPro IPR031304 SLT_2 # KEGG_Brite ko01000 Enzymes # Organism MLTB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30163 PTHR30163 # PATRIC 32120800 VBIEscCol129921_2792 # PDB 1D0K X-ray; 2.02 A; A=40-361 # PDB 1D0L X-ray; 1.97 A; A=40-361 # PDB 1D0M X-ray; 2.47 A; A=40-361 # PDB 1LTM X-ray; 1.70 A; A=42-361 # PDB 1QDR X-ray; 2.10 A; A=40-361 # PDB 1QDT X-ray; 2.10 A; A=40-361 # PDB 1QUS X-ray; 1.70 A; A=40-361 # PDB 1QUT X-ray; 2.44 A; A=40-361 # PIR A65050 A65050 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF13406 SLT_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MLTB_ECOLI Membrane-bound lytic murein transglycosylase B # RefSeq NP_417181 NC_000913.3 # RefSeq WP_001295177 NZ_LN832404.1 # SUBCELLULAR LOCATION MLTB_ECOLI Cell outer membrane; Lipid-anchor; Periplasmic side. # SUBUNIT MLTB_ECOLI Monomer. # SUPFAM SSF53955 SSF53955 # TIGRFAMs TIGR02282 MltB # eggNOG COG2951 LUCA # eggNOG ENOG4105CVE Bacteria BLAST swissprot:MLTB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MLTB_ECOLI BioCyc ECOL316407:JW2671-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2671-MONOMER BioCyc EcoCyc:G7410-MONOMER http://biocyc.org/getid?id=EcoCyc:G7410-MONOMER BioCyc MetaCyc:G7410-MONOMER http://biocyc.org/getid?id=MetaCyc:G7410-MONOMER COG COG2951 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2951 DIP DIP-10221N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10221N DOI 10.1016/0014-5793(95)00505-4 http://dx.doi.org/10.1016/0014-5793(95)00505-4 DOI 10.1016/S0014-5793(99)01198-9 http://dx.doi.org/10.1016/S0014-5793(99)01198-9 DOI 10.1016/S0969-2126(00)80051-9 http://dx.doi.org/10.1016/S0969-2126(00)80051-9 DOI 10.1021/bi992161p http://dx.doi.org/10.1021/bi992161p DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1107/S0907444997010330 http://dx.doi.org/10.1107/S0907444997010330 DOI 10.1111/j.1365-2958.1995.tb02437.x http://dx.doi.org/10.1111/j.1365-2958.1995.tb02437.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.2.n1 http://www.genome.jp/dbget-bin/www_bget?EC:4.2.2.n1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J02708 http://www.ebi.ac.uk/ena/data/view/J02708 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18785 http://www.ebi.ac.uk/ena/data/view/U18785 ENZYME 4.2.2.n1 http://enzyme.expasy.org/EC/4.2.2.n1 EchoBASE EB2561 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2561 EcoGene EG12699 http://www.ecogene.org/geneInfo.php?eg_id=EG12699 EnsemblBacteria AAC75743 http://www.ensemblgenomes.org/id/AAC75743 EnsemblBacteria AAC75743 http://www.ensemblgenomes.org/id/AAC75743 EnsemblBacteria BAA16563 http://www.ensemblgenomes.org/id/BAA16563 EnsemblBacteria BAA16563 http://www.ensemblgenomes.org/id/BAA16563 EnsemblBacteria BAA16563 http://www.ensemblgenomes.org/id/BAA16563 EnsemblBacteria b2701 http://www.ensemblgenomes.org/id/b2701 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_function GO:0008933 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008933 GO_function GO:0052762 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052762 GO_function GO:0052764 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052764 GO_process GO:0009252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009252 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 GeneID 947184 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947184 HOGENOM HOG000257828 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000257828&db=HOGENOM6 InParanoid P41052 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P41052 IntAct P41052 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P41052* IntEnz 4.2.2.n1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.2.n1 InterPro IPR011757 http://www.ebi.ac.uk/interpro/entry/IPR011757 InterPro IPR023346 http://www.ebi.ac.uk/interpro/entry/IPR023346 InterPro IPR031304 http://www.ebi.ac.uk/interpro/entry/IPR031304 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2671 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2671 KEGG_Gene eco:b2701 http://www.genome.jp/dbget-bin/www_bget?eco:b2701 KEGG_Orthology KO:K08305 http://www.genome.jp/dbget-bin/www_bget?KO:K08305 MINT MINT-1257117 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1257117 OMA SSIRDYA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SSIRDYA PANTHER PTHR30163 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30163 PDB 1D0K http://www.ebi.ac.uk/pdbe-srv/view/entry/1D0K PDB 1D0L http://www.ebi.ac.uk/pdbe-srv/view/entry/1D0L PDB 1D0M http://www.ebi.ac.uk/pdbe-srv/view/entry/1D0M PDB 1LTM http://www.ebi.ac.uk/pdbe-srv/view/entry/1LTM PDB 1QDR http://www.ebi.ac.uk/pdbe-srv/view/entry/1QDR PDB 1QDT http://www.ebi.ac.uk/pdbe-srv/view/entry/1QDT PDB 1QUS http://www.ebi.ac.uk/pdbe-srv/view/entry/1QUS PDB 1QUT http://www.ebi.ac.uk/pdbe-srv/view/entry/1QUT PDBsum 1D0K http://www.ebi.ac.uk/pdbsum/1D0K PDBsum 1D0L http://www.ebi.ac.uk/pdbsum/1D0L PDBsum 1D0M http://www.ebi.ac.uk/pdbsum/1D0M PDBsum 1LTM http://www.ebi.ac.uk/pdbsum/1LTM PDBsum 1QDR http://www.ebi.ac.uk/pdbsum/1QDR PDBsum 1QDT http://www.ebi.ac.uk/pdbsum/1QDT PDBsum 1QUS http://www.ebi.ac.uk/pdbsum/1QUS PDBsum 1QUT http://www.ebi.ac.uk/pdbsum/1QUT PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:MLTB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MLTB_ECOLI PSORT-B swissprot:MLTB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MLTB_ECOLI PSORT2 swissprot:MLTB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MLTB_ECOLI Pfam PF13406 http://pfam.xfam.org/family/PF13406 Phobius swissprot:MLTB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MLTB_ECOLI PhylomeDB P41052 http://phylomedb.org/?seqid=P41052 ProteinModelPortal P41052 http://www.proteinmodelportal.org/query/uniprot/P41052 PubMed 10545329 http://www.ncbi.nlm.nih.gov/pubmed/10545329 PubMed 10570954 http://www.ncbi.nlm.nih.gov/pubmed/10570954 PubMed 10684641 http://www.ncbi.nlm.nih.gov/pubmed/10684641 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3553176 http://www.ncbi.nlm.nih.gov/pubmed/3553176 PubMed 7476170 http://www.ncbi.nlm.nih.gov/pubmed/7476170 PubMed 7789526 http://www.ncbi.nlm.nih.gov/pubmed/7789526 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9761817 http://www.ncbi.nlm.nih.gov/pubmed/9761817 RefSeq NP_417181 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417181 RefSeq WP_001295177 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295177 SMR P41052 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P41052 STRING 511145.b2701 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2701&targetmode=cogs STRING COG2951 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2951&targetmode=cogs SUPFAM SSF53955 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53955 TIGRFAMs TIGR02282 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02282 UniProtKB MLTB_ECOLI http://www.uniprot.org/uniprot/MLTB_ECOLI UniProtKB-AC P41052 http://www.uniprot.org/uniprot/P41052 charge swissprot:MLTB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MLTB_ECOLI eggNOG COG2951 http://eggnogapi.embl.de/nog_data/html/tree/COG2951 eggNOG ENOG4105CVE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CVE epestfind swissprot:MLTB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MLTB_ECOLI garnier swissprot:MLTB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MLTB_ECOLI helixturnhelix swissprot:MLTB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MLTB_ECOLI hmoment swissprot:MLTB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MLTB_ECOLI iep swissprot:MLTB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MLTB_ECOLI inforesidue swissprot:MLTB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MLTB_ECOLI octanol swissprot:MLTB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MLTB_ECOLI pepcoil swissprot:MLTB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MLTB_ECOLI pepdigest swissprot:MLTB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MLTB_ECOLI pepinfo swissprot:MLTB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MLTB_ECOLI pepnet swissprot:MLTB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MLTB_ECOLI pepstats swissprot:MLTB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MLTB_ECOLI pepwheel swissprot:MLTB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MLTB_ECOLI pepwindow swissprot:MLTB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MLTB_ECOLI sigcleave swissprot:MLTB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MLTB_ECOLI ## Database ID URL or Descriptions # AltName NUOG_ECOLI NADH dehydrogenase I subunit G # AltName NUOG_ECOLI NDH-1 subunit G # AltName NUOG_ECOLI NUO7 # BioGrid 4260512 22 # CATALYTIC ACTIVITY NUOG_ECOLI NADH + a quinone = NAD(+) + a quinol. # CDD cd00207 fer2 # COFACTOR NUOG_ECOLI Name=[2Fe-2S] cluster; Xref=ChEBI CHEBI 49601; Evidence={ECO 0000250}; Note=Binds 1 [2Fe-2S] cluster per subunit. {ECO 0000250}; # COFACTOR NUOG_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000250}; Note=Binds 3 [4Fe-4S] clusters per subunit. {ECO 0000250}; # EcoGene EG12087 nuoG # FUNCTION NUOG_ECOLI NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. # GO_component GO:0005886 plasma membrane; IDA:EcoliWiki. # GO_component GO:0030964 NADH dehydrogenase complex; IDA:EcoliWiki. # GO_component GO:0045272 plasma membrane respiratory chain complex I; IDA:EcoCyc. # GO_function GO:0008137 NADH dehydrogenase (ubiquinone) activity; IEA:InterPro. # GO_function GO:0009055 electron carrier activity; IEA:InterPro. # GO_function GO:0030151 molybdenum ion binding; IEA:InterPro. # GO_function GO:0048038 quinone binding; IEA:UniProtKB-KW. # GO_function GO:0051537 2 iron, 2 sulfur cluster binding; IDA:EcoCyc. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IDA:EcoCyc. # GO_process GO:0009060 aerobic respiration; IMP:EcoCyc. # GO_process GO:0042773 ATP synthesis coupled electron transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # Gene3D 3.10.20.30 -; 1. # INTERACTION NUOG_ECOLI P33599 nuoC; NbExp=2; IntAct=EBI-559737, EBI-552399; P0AFD1 nuoE; NbExp=4; IntAct=EBI-559737, EBI-1117136; # IntAct P33602 31 # InterPro IPR000283 NADH_UbQ_OxRdtase_75kDa_su_CS # InterPro IPR001041 2Fe-2S_ferredoxin-type # InterPro IPR006656 Mopterin_OxRdtase # InterPro IPR006657 MoPterin_dinucl-bd_dom # InterPro IPR006963 Mopterin_OxRdtase_4Fe-4S_dom # InterPro IPR009010 Asp_de-COase-like_dom # InterPro IPR010228 NADH_UbQ_OxRdtase_Gsu # InterPro IPR012675 Beta-grasp_dom # InterPro IPR019574 NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00190 Oxidative phosphorylation # KEGG_Pathway ko00910 Nitrogen metabolism # Organism NUOG_ECOLI Escherichia coli (strain K12) # PATRIC 32119933 VBIEscCol129921_2376 # PIR A65000 A65000 # PROSITE PS00641 COMPLEX1_75K_1 # PROSITE PS00642 COMPLEX1_75K_2 # PROSITE PS00643 COMPLEX1_75K_3 # PROSITE PS51085 2FE2S_FER_2 # PROSITE PS51669 4FE4S_MOW_BIS_MGD # Pfam PF00384 Molybdopterin # Pfam PF01568 Molydop_binding # Pfam PF04879 Molybdop_Fe4S4 # Pfam PF10588 NADH-G_4Fe-4S_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NUOG_ECOLI NADH-quinone oxidoreductase subunit G # RefSeq NP_416786 NC_000913.3 # RefSeq WP_000190939 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA16111.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA48366.1; Type=Frameshift; Positions=715, 806; Evidence={ECO 0000305}; # SIMILARITY Belongs to the complex I 75 kDa subunit family. {ECO 0000305}. # SIMILARITY Contains 1 2Fe-2S ferredoxin-type domain. {ECO:0000255|PROSITE-ProRule PRU00465}. # SIMILARITY Contains 1 4Fe-4S Mo/W bis-MGD-type domain. {ECO:0000255|PROSITE-ProRule PRU01004}. # SMART SM00926 Molybdop_Fe4S4 # SMART SM00929 NADH-G_4Fe-4S_3 # SUBCELLULAR LOCATION NUOG_ECOLI Cytoplasm {ECO 0000269|PubMed 16079137}. Cell inner membrane {ECO 0000269|PubMed 16079137}; Peripheral membrane protein {ECO 0000269|PubMed 16079137}. # SUBUNIT NUOG_ECOLI Composed of 13 different subunits. Subunits NuoCD, E, F, and G constitute the peripheral sector of the complex. # SUPFAM SSF50692 SSF50692 # SUPFAM SSF54292 SSF54292 # TCDB 3.D.1.1 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family # TIGRFAMs TIGR01973 NuoG # eggNOG COG1034 LUCA # eggNOG ENOG4107R0R Bacteria BLAST swissprot:NUOG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NUOG_ECOLI BioCyc ECOL316407:JW2278-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2278-MONOMER BioCyc EcoCyc:NUOG-MONOMER http://biocyc.org/getid?id=EcoCyc:NUOG-MONOMER BioCyc MetaCyc:NUOG-MONOMER http://biocyc.org/getid?id=MetaCyc:NUOG-MONOMER COG COG1034 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1034 DIP DIP-10383N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10383N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1993.1488 http://dx.doi.org/10.1006/jmbi.1993.1488 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.6.5.11 http://www.genome.jp/dbget-bin/www_bget?EC:1.6.5.11 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L25055 http://www.ebi.ac.uk/ena/data/view/L25055 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X68301 http://www.ebi.ac.uk/ena/data/view/X68301 ENZYME 1.6.5.11 http://enzyme.expasy.org/EC/1.6.5.11 EchoBASE EB2011 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2011 EcoGene EG12087 http://www.ecogene.org/geneInfo.php?eg_id=EG12087 EnsemblBacteria AAC75343 http://www.ensemblgenomes.org/id/AAC75343 EnsemblBacteria AAC75343 http://www.ensemblgenomes.org/id/AAC75343 EnsemblBacteria BAA16111 http://www.ensemblgenomes.org/id/BAA16111 EnsemblBacteria BAA16111 http://www.ensemblgenomes.org/id/BAA16111 EnsemblBacteria BAA16111 http://www.ensemblgenomes.org/id/BAA16111 EnsemblBacteria b2283 http://www.ensemblgenomes.org/id/b2283 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0030964 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030964 GO_component GO:0045272 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045272 GO_function GO:0008137 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008137 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0030151 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030151 GO_function GO:0048038 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048038 GO_function GO:0051537 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051537 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0009060 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009060 GO_process GO:0042773 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042773 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 Gene3D 3.10.20.30 http://www.cathdb.info/version/latest/superfamily/3.10.20.30 GeneID 946762 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946762 HOGENOM HOG000276177 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276177&db=HOGENOM6 InParanoid P33602 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33602 IntAct P33602 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33602* IntEnz 1.6.5.11 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.6.5.11 InterPro IPR000283 http://www.ebi.ac.uk/interpro/entry/IPR000283 InterPro IPR001041 http://www.ebi.ac.uk/interpro/entry/IPR001041 InterPro IPR006656 http://www.ebi.ac.uk/interpro/entry/IPR006656 InterPro IPR006657 http://www.ebi.ac.uk/interpro/entry/IPR006657 InterPro IPR006963 http://www.ebi.ac.uk/interpro/entry/IPR006963 InterPro IPR009010 http://www.ebi.ac.uk/interpro/entry/IPR009010 InterPro IPR010228 http://www.ebi.ac.uk/interpro/entry/IPR010228 InterPro IPR012675 http://www.ebi.ac.uk/interpro/entry/IPR012675 InterPro IPR019574 http://www.ebi.ac.uk/interpro/entry/IPR019574 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2278 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2278 KEGG_Gene eco:b2283 http://www.genome.jp/dbget-bin/www_bget?eco:b2283 KEGG_Orthology KO:K00336 http://www.genome.jp/dbget-bin/www_bget?KO:K00336 KEGG_Pathway ko00190 http://www.genome.jp/kegg-bin/show_pathway?ko00190 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Reaction rn:R02166 http://www.genome.jp/dbget-bin/www_bget?rn:R02166 MINT MINT-1244767 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1244767 OMA GYGYVNR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GYGYVNR PROSITE PS00641 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00641 PROSITE PS00642 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00642 PROSITE PS00643 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00643 PROSITE PS51085 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51085 PROSITE PS51669 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51669 PSORT swissprot:NUOG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NUOG_ECOLI PSORT-B swissprot:NUOG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NUOG_ECOLI PSORT2 swissprot:NUOG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NUOG_ECOLI Pfam PF00384 http://pfam.xfam.org/family/PF00384 Pfam PF01568 http://pfam.xfam.org/family/PF01568 Pfam PF04879 http://pfam.xfam.org/family/PF04879 Pfam PF10588 http://pfam.xfam.org/family/PF10588 Phobius swissprot:NUOG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NUOG_ECOLI PhylomeDB P33602 http://phylomedb.org/?seqid=P33602 ProteinModelPortal P33602 http://www.proteinmodelportal.org/query/uniprot/P33602 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7690854 http://www.ncbi.nlm.nih.gov/pubmed/7690854 PubMed 8157582 http://www.ncbi.nlm.nih.gov/pubmed/8157582 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_416786 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416786 RefSeq WP_000190939 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000190939 SMART SM00926 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00926 SMART SM00929 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00929 STRING 511145.b2283 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2283&targetmode=cogs STRING COG1034 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1034&targetmode=cogs SUPFAM SSF50692 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50692 SUPFAM SSF54292 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54292 TCDB 3.D.1.1 http://www.tcdb.org/search/result.php?tc=3.D.1.1 TIGRFAMs TIGR01973 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01973 UniProtKB NUOG_ECOLI http://www.uniprot.org/uniprot/NUOG_ECOLI UniProtKB-AC P33602 http://www.uniprot.org/uniprot/P33602 charge swissprot:NUOG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NUOG_ECOLI eggNOG COG1034 http://eggnogapi.embl.de/nog_data/html/tree/COG1034 eggNOG ENOG4107R0R http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107R0R epestfind swissprot:NUOG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NUOG_ECOLI garnier swissprot:NUOG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NUOG_ECOLI helixturnhelix swissprot:NUOG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NUOG_ECOLI hmoment swissprot:NUOG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NUOG_ECOLI iep swissprot:NUOG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NUOG_ECOLI inforesidue swissprot:NUOG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NUOG_ECOLI octanol swissprot:NUOG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NUOG_ECOLI pepcoil swissprot:NUOG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NUOG_ECOLI pepdigest swissprot:NUOG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NUOG_ECOLI pepinfo swissprot:NUOG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NUOG_ECOLI pepnet swissprot:NUOG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NUOG_ECOLI pepstats swissprot:NUOG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NUOG_ECOLI pepwheel swissprot:NUOG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NUOG_ECOLI pepwindow swissprot:NUOG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NUOG_ECOLI sigcleave swissprot:NUOG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NUOG_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES MSRC_ECOLI Kinetic parameters KM=3.9 mM for L-methionine-(R)-S-oxide {ECO 0000269|PubMed 17535911}; KM=9.8 uM for thioredoxin {ECO 0000269|PubMed 17535911}; # BRENDA 1.8.4.14 2026 # BioGrid 4259156 10 # CATALYTIC ACTIVITY L-methionine + thioredoxin disulfide + H(2)O = L-methionine (R)-S-oxide + thioredoxin. {ECO:0000269|PubMed 17535911}. # EcoGene EG14020 msrC # FUNCTION MSRC_ECOLI Catalyzes the reversible oxidation-reduction of the R- enantiomer of free methionine sulfoxide to methionine. Specific for free L-methionine-(R)-S-oxide. {ECO 0000269|PubMed 17535911}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor; IDA:EcoCyc. # GO_function GO:0033745 L-methionine-(R)-S-oxide reductase activity; IEA:UniProtKB-EC. # GO_process GO:0006979 response to oxidative stress; EXP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006950 response to stress # Gene3D 3.30.450.40 -; 1. # IntAct P76270 8 # InterPro IPR000614 fRMsr_CS # InterPro IPR003018 GAF # InterPro IPR029016 GAF_dom-like # Organism MSRC_ECOLI Escherichia coli (strain K12) # PATRIC 32118985 VBIEscCol129921_1910 # PDB 1VHM X-ray; 2.10 A; A/B=1-165 # PIR H64944 H64944 # PROSITE PS01320 UPF0067 # Pfam PF13185 GAF_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MSRC_ECOLI Free methionine-R-sulfoxide reductase # RefSeq NP_416346 NC_000913.3 # RefSeq WP_001043877 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA15640.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the free Met sulfoxide reductase family. {ECO 0000305}. # SIMILARITY Contains 1 GAF domain. {ECO 0000305}. # SMART SM00065 GAF # SUPFAM SSF55781 SSF55781 # eggNOG COG1956 LUCA # eggNOG ENOG4108ZGC Bacteria BLAST swissprot:MSRC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MSRC_ECOLI BioCyc ECOL316407:JW1821-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1821-MONOMER BioCyc EcoCyc:G7005-MONOMER http://biocyc.org/getid?id=EcoCyc:G7005-MONOMER BioCyc MetaCyc:G7005-MONOMER http://biocyc.org/getid?id=MetaCyc:G7005-MONOMER COG COG1956 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1956 DIP DIP-11813N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11813N DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1002/prot.20541 http://dx.doi.org/10.1002/prot.20541 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0703774104 http://dx.doi.org/10.1073/pnas.0703774104 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.8.4.14 http://www.genome.jp/dbget-bin/www_bget?EC:1.8.4.14 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.8.4.14 http://enzyme.expasy.org/EC/1.8.4.14 EchoBASE EB3774 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3774 EcoGene EG14020 http://www.ecogene.org/geneInfo.php?eg_id=EG14020 EnsemblBacteria AAC74902 http://www.ensemblgenomes.org/id/AAC74902 EnsemblBacteria AAC74902 http://www.ensemblgenomes.org/id/AAC74902 EnsemblBacteria BAA15640 http://www.ensemblgenomes.org/id/BAA15640 EnsemblBacteria BAA15640 http://www.ensemblgenomes.org/id/BAA15640 EnsemblBacteria BAA15640 http://www.ensemblgenomes.org/id/BAA15640 EnsemblBacteria b1832 http://www.ensemblgenomes.org/id/b1832 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0016671 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016671 GO_function GO:0033745 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033745 GO_process GO:0006979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.30.450.40 http://www.cathdb.info/version/latest/superfamily/3.30.450.40 GeneID 946086 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946086 HOGENOM HOG000022909 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000022909&db=HOGENOM6 InParanoid P76270 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76270 IntAct P76270 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76270* IntEnz 1.8.4.14 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.8.4.14 InterPro IPR000614 http://www.ebi.ac.uk/interpro/entry/IPR000614 InterPro IPR003018 http://www.ebi.ac.uk/interpro/entry/IPR003018 InterPro IPR029016 http://www.ebi.ac.uk/interpro/entry/IPR029016 KEGG_Gene ecj:JW1821 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1821 KEGG_Gene eco:b1832 http://www.genome.jp/dbget-bin/www_bget?eco:b1832 KEGG_Orthology KO:K07170 http://www.genome.jp/dbget-bin/www_bget?KO:K07170 OMA FQGQPAC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FQGQPAC PDB 1VHM http://www.ebi.ac.uk/pdbe-srv/view/entry/1VHM PDBsum 1VHM http://www.ebi.ac.uk/pdbsum/1VHM PROSITE PS01320 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01320 PSORT swissprot:MSRC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MSRC_ECOLI PSORT-B swissprot:MSRC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MSRC_ECOLI PSORT2 swissprot:MSRC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MSRC_ECOLI Pfam PF13185 http://pfam.xfam.org/family/PF13185 Phobius swissprot:MSRC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MSRC_ECOLI PhylomeDB P76270 http://phylomedb.org/?seqid=P76270 ProteinModelPortal P76270 http://www.proteinmodelportal.org/query/uniprot/P76270 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 16021622 http://www.ncbi.nlm.nih.gov/pubmed/16021622 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17535911 http://www.ncbi.nlm.nih.gov/pubmed/17535911 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416346 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416346 RefSeq WP_001043877 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001043877 SMART SM00065 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00065 SMR P76270 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76270 STRING 511145.b1832 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1832&targetmode=cogs STRING COG1956 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1956&targetmode=cogs SUPFAM SSF55781 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55781 SWISS-2DPAGE P76270 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P76270 UniProtKB MSRC_ECOLI http://www.uniprot.org/uniprot/MSRC_ECOLI UniProtKB-AC P76270 http://www.uniprot.org/uniprot/P76270 charge swissprot:MSRC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MSRC_ECOLI eggNOG COG1956 http://eggnogapi.embl.de/nog_data/html/tree/COG1956 eggNOG ENOG4108ZGC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZGC epestfind swissprot:MSRC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MSRC_ECOLI garnier swissprot:MSRC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MSRC_ECOLI helixturnhelix swissprot:MSRC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MSRC_ECOLI hmoment swissprot:MSRC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MSRC_ECOLI iep swissprot:MSRC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MSRC_ECOLI inforesidue swissprot:MSRC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MSRC_ECOLI octanol swissprot:MSRC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MSRC_ECOLI pepcoil swissprot:MSRC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MSRC_ECOLI pepdigest swissprot:MSRC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MSRC_ECOLI pepinfo swissprot:MSRC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MSRC_ECOLI pepnet swissprot:MSRC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MSRC_ECOLI pepstats swissprot:MSRC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MSRC_ECOLI pepwheel swissprot:MSRC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MSRC_ECOLI pepwindow swissprot:MSRC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MSRC_ECOLI sigcleave swissprot:MSRC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MSRC_ECOLI ## Database ID URL or Descriptions # BioGrid 4259148 14 # EcoGene EG14014 yebO # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR025594 YebO # Organism YEBO_ECOLI Escherichia coli (strain K12) # PATRIC 32118969 VBIEscCol129921_1902 # PIR A64944 A64944 # Pfam PF13974 YebO # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEBO_ECOLI Uncharacterized protein YebO # RefSeq NP_416339 NC_000913.3 # RefSeq WP_001006866 NZ_LN832404.1 # SUBCELLULAR LOCATION YEBO_ECOLI Cell membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. # eggNOG ENOG4105Q3Y Bacteria # eggNOG ENOG4111ZGK LUCA BLAST swissprot:YEBO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEBO_ECOLI BioCyc ECOL316407:JW1814-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1814-MONOMER BioCyc EcoCyc:G7001-MONOMER http://biocyc.org/getid?id=EcoCyc:G7001-MONOMER DIP DIP-48171N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48171N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3770 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3770 EcoGene EG14014 http://www.ecogene.org/geneInfo.php?eg_id=EG14014 EnsemblBacteria AAC74895 http://www.ensemblgenomes.org/id/AAC74895 EnsemblBacteria AAC74895 http://www.ensemblgenomes.org/id/AAC74895 EnsemblBacteria BAE76538 http://www.ensemblgenomes.org/id/BAE76538 EnsemblBacteria BAE76538 http://www.ensemblgenomes.org/id/BAE76538 EnsemblBacteria BAE76538 http://www.ensemblgenomes.org/id/BAE76538 EnsemblBacteria b1825 http://www.ensemblgenomes.org/id/b1825 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 946350 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946350 HOGENOM HOG000121175 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000121175&db=HOGENOM6 InterPro IPR025594 http://www.ebi.ac.uk/interpro/entry/IPR025594 KEGG_Gene ecj:JW1814 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1814 KEGG_Gene eco:b1825 http://www.genome.jp/dbget-bin/www_bget?eco:b1825 OMA VLWFFVN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VLWFFVN PSORT swissprot:YEBO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEBO_ECOLI PSORT-B swissprot:YEBO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEBO_ECOLI PSORT2 swissprot:YEBO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEBO_ECOLI Pfam PF13974 http://pfam.xfam.org/family/PF13974 Phobius swissprot:YEBO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEBO_ECOLI ProteinModelPortal P64499 http://www.proteinmodelportal.org/query/uniprot/P64499 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416339 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416339 RefSeq WP_001006866 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001006866 STRING 511145.b1825 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1825&targetmode=cogs UniProtKB YEBO_ECOLI http://www.uniprot.org/uniprot/YEBO_ECOLI UniProtKB-AC P64499 http://www.uniprot.org/uniprot/P64499 charge swissprot:YEBO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEBO_ECOLI eggNOG ENOG4105Q3Y http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105Q3Y eggNOG ENOG4111ZGK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111ZGK epestfind swissprot:YEBO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEBO_ECOLI garnier swissprot:YEBO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEBO_ECOLI helixturnhelix swissprot:YEBO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEBO_ECOLI hmoment swissprot:YEBO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEBO_ECOLI iep swissprot:YEBO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEBO_ECOLI inforesidue swissprot:YEBO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEBO_ECOLI octanol swissprot:YEBO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEBO_ECOLI pepcoil swissprot:YEBO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEBO_ECOLI pepdigest swissprot:YEBO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEBO_ECOLI pepinfo swissprot:YEBO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEBO_ECOLI pepnet swissprot:YEBO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEBO_ECOLI pepstats swissprot:YEBO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEBO_ECOLI pepwheel swissprot:YEBO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEBO_ECOLI pepwindow swissprot:YEBO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEBO_ECOLI sigcleave swissprot:YEBO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEBO_ECOLI ## Database ID URL or Descriptions # BioGrid 4262132 260 # CATALYTIC ACTIVITY GYRA_ECOLI ATP-dependent breakage, passage and rejoining of double-stranded DNA. {ECO 0000255|HAMAP-Rule MF_01897, ECO 0000269|PubMed 12051842, ECO 0000269|PubMed 18642932, ECO 0000269|PubMed 186775, ECO 0000269|PubMed 19965760, ECO 0000269|PubMed 9278055}. # DOMAIN GYRA_ECOLI An N-terminal fragment (residues 1-523) can be reconstituted with GyrB, but the complex no longer has negative supercoiling or ATP-independent DNA relaxation activities, although it is capable of DNA cleavage; ATP-dependent relaxation is inhibited by novobiocin and non-hydrolyzable ATP analogs (PubMed 8962066). The fragment has ATP-dependent DNA relaxation and 30-fold improved decatenation activities, unlike holoenzyme it preferentially binds supercoiled DNA (PubMed 8962066). This N- terminal fragment becomes a topoisomerase IV-like enzyme; it poorly complements a temperature-sensitive parC mutation (parC is the topoisomerase IV paralog of gyrA) (PubMed 8962066). {ECO 0000269|PubMed 8962066}. # DOMAIN GYRA_ECOLI The C-terminal domain (CTD, approximately residues 535- 841) contains 6 tandemly repeated subdomains known as blades, each of which is composed of a 4-stranded antiparallel beta-sheet (PubMed 15897198). The blades form a circular-shaped beta-pinwheel fold arranged in a spiral around a screw axis, to which DNA probably binds, inducing strong positive superhelicity (about 0.8 links/protein) (PubMed 15897198). The non-conserved, C-terminal acidic tail (residues 842-875) regulates wrapping and DNA-binding by the CTD; deletions within the tail show it is autoinhibitory for DNA wrapping and binding, and couples ATP hydrolysis to DNA strand passage (PubMed 22457353). The GyrA-box is a 7 amino acid motif found in the first blade of the CTD which is discriminative for gyrase versus topoisomerase IV activity (PubMed 9426128). The GyrA-box is required for wrapping of DNA around gyrase, and thus is essential for the DNA supercoiling activity but not DNA relaxation or decatenation activities of gyrase (PubMed 16332690). {ECO 0000269|PubMed 15897198, ECO 0000269|PubMed 16332690, ECO 0000269|PubMed 22457353, ECO 0000305|PubMed 9426128}. # DrugBank DB00537 Ciprofloxacin # ENZYME REGULATION GYRA_ECOLI Gyrase is the target of many classes of inhibitors, including coumarins, cyclothialidines, pyrrolopyrimidines, pyrazolthiazoles and (fluoro)quinolones. Quinolones bind GyrA when the enzyme is complexed with DNA and trap the enzyme in a covalent reaction intermediate with DNA (PubMed 3031051, PubMed 12051842). Coumarins bind to GyrB and are competitive inhibitors of its ATPase activity (PubMed 7811004). Cyclothialidines also bind GyrB and are ATPase competitive inhibitors; they seem to act differently from coumarins (PubMed 7811004). Pyrrolopyrimidines inhibit both GyrB and its paralog in topoisomerase IV (parE) (PubMed 23294697). Pyrazolthiazoles also inhibit the ATPase activity of GyrB (PubMed 20356737). DNA supercoiling and relaxation are both inhibited by oxolinic acid (PubMed 337300). Acriflavine inhibits supercoiling activity and DNA-stimulated ATPase activity (PubMed 9148951). DNA supercoiling activity is protected from fluoroquinolone inhibition by QnrB4; QnrB4 has no effect on supercoiling activity alone (PubMed 19060136). {ECO 0000269|PubMed 19060136, ECO 0000269|PubMed 20356737, ECO 0000269|PubMed 23294697, ECO 0000269|PubMed 337300, ECO 0000269|PubMed 7811004, ECO 0000269|PubMed 9148951}. # EcoGene EG10423 gyrA # FUNCTION GYRA_ECOLI A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state (PubMed 3031051, PubMed 186775, PubMed 7811004, PubMed 9148951, PubMed 12051842, PubMed 18642932, PubMed 19060136, PubMed 20356737, PubMed 22457353, PubMed 23294697, PubMed 19965760). This makes better substrates for topoisomerase IV (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli (PubMed 9334322). Gyrase catalyzes the interconversion of other topological isomers of dsDNA rings, including catenanes (PubMed 22457352). Relaxes negatively supercoiled DNA in an ATP-independent manner (PubMed 337300). E.coli gyrase has higher supercoiling activity than many other bacterial gyrases; at comparable concentrations E.coli gyrase introduces more supercoils faster than M.tuberculosis gyrase, while M.tuberculosis gyrase has higher decatenation than supercoiling activity compared to E.coli (PubMed 22457352). E.coli makes 15% more negative supercoils in pBR322 plasmid DNA than S.typhimurium; the S.typhimurium GyrB subunit is toxic in E.coli, while the E.coli copy can be expressed in S.typhimurium even though the 2 subunits have 777/804 residues identical (PubMed 17400739). The enzymatic differences between E.coli gyrase and topoisomerase IV are largely due to the GyrA C- terminal domain (approximately residues 524-841) and specifically the GyrA-box (PubMed 8962066, PubMed 16332690). {ECO 0000269|PubMed 12051842, ECO 0000269|PubMed 16332690, ECO 0000269|PubMed 17400739, ECO 0000269|PubMed 18642932, ECO 0000269|PubMed 186775, ECO 0000269|PubMed 19060136, ECO 0000269|PubMed 19965760, ECO 0000269|PubMed 20356737, ECO 0000269|PubMed 22457352, ECO 0000269|PubMed 22457353, ECO 0000269|PubMed 23294697, ECO 0000269|PubMed 3031051, ECO 0000269|PubMed 337300, ECO 0000269|PubMed 7811004, ECO 0000269|PubMed 8962066, ECO 0000269|PubMed 9148951, ECO 0000269|PubMed 9334322}. # FUNCTION GYRA_ECOLI Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. # GO_component GO:0005694 chromosome; IEA:InterPro. # GO_component GO:0005737 cytoplasm; IDA:UniProtKB. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0009295 nucleoid; IBA:GO_Central. # GO_component GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing); IBA:GO_Central. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0003677 DNA binding; IDA:EcoliWiki. # GO_function GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity; IDA:CACAO. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008094 DNA-dependent ATPase activity; IDA:EcoliWiki. # GO_function GO:0034335 DNA supercoiling activity; IDA:UniProtKB. # GO_process GO:0006265 DNA topological change; IMP:EcoliWiki. # GO_process GO:0006268 DNA unwinding involved in DNA replication; IBA:GO_Central. # GO_process GO:0006351 transcription, DNA-templated; IDA:EcoliWiki. # GO_process GO:0007059 chromosome segregation; IBA:GO_Central. # GO_process GO:0042493 response to drug; IMP:EcoliWiki. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005694 chromosome # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0007059 chromosome segregation # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0051276 chromosome organization # Gene3D 1.10.268.10 -; 1. # Gene3D 3.30.1360.40 -; 1. # Gene3D 3.90.199.10 -; 1. # HAMAP MF_01897 GyrA # INTERACTION GYRA_ECOLI Self; NbExp=2; IntAct=EBI-547129, EBI-547129; P0AES6 gyrB; NbExp=5; IntAct=EBI-547129, EBI-541911; P27245 marR; NbExp=2; IntAct=EBI-547129, EBI-6409744; # IntAct P0AES4 51 # InterPro IPR002205 Topo_IIA_A/C # InterPro IPR005743 GyrA # InterPro IPR006691 GyrA/parC_pinwhl # InterPro IPR013757 Topo_IIA_A_a # InterPro IPR013758 Topo_IIA_A/C_ab # InterPro IPR013760 Topo_IIA-like_dom # InterPro IPR024946 Arg_repress_C-like # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03032 DNA replication proteins # KEGG_Brite ko03400 DNA repair and recombination proteins # MISCELLANEOUS GYRA_ECOLI Few gyrases are as efficient as E.coli at forming negative supercoils (PubMed 22457352, PubMed 17400739). Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes. {ECO 0000255|HAMAP-Rule MF_01897, ECO 0000269|PubMed 17400739, ECO 0000269|PubMed 22457352}. # MISCELLANEOUS GYRA_ECOLI When the enzyme transiently cleaves DNA a phosphotyrosine bond is formed between GyrA and DNA (PubMed 3031051). In the presence of quinolones this intermediate can be trapped and is used as an indicator of drug toxicity (PubMed 12051842). The enzyme-DNA intermediate is also the target of a number of topoisomerase poisons, including toxin CcdB (PubMed 1324324, PubMed 8254658). {ECO 0000269|PubMed 1324324, ECO 0000269|PubMed 3031051, ECO 0000269|PubMed 8254658, ECO 0000305|PubMed 12051842}. # Organism GYRA_ECOLI Escherichia coli (strain K12) # PATRIC 32119821 VBIEscCol129921_2320 # PDB 1AB4 X-ray; 2.80 A; A=30-522 # PDB 1X75 X-ray; 2.80 A; A/B=363-494 # PDB 1ZI0 X-ray; 2.60 A; A/B=535-841 # PDB 2Y3P X-ray; 2.62 A; A/B=2-523 # PDB 3NUH X-ray; 3.10 A; A=1-525 # PDB 4ELY X-ray; 1.93 A; A/B=363-497 # PIR S02340 ITECAP # Pfam PF00521 DNA_topoisoIV # Pfam PF03989 DNA_gyraseA_C; 6 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DNA gyrase subunit A {ECO:0000255|HAMAP-Rule MF_01897} # RefSeq NP_416734 NC_000913.3 # RefSeq WP_001281242 NZ_LN832404.1 # SIMILARITY Belongs to the type II topoisomerase GyrA/ParC subunit family. {ECO:0000255|HAMAP-Rule MF_01897}. # SMART SM00434 TOP4c # SUBCELLULAR LOCATION GYRA_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_01897}. # SUBUNIT GYRA_ECOLI Heterotetramer, composed of two GyrA and two GyrB chains (PubMed 9148951, PubMed 12051842). In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with the DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis (PubMed 12051842, PubMed 18642932, PubMed 19965760, PubMed 9148951). Can form a 2 2 complex with toxin CcdB in which GyrA is inactive; rejuvenation of GyrA(2)CcdB(2) is effected by CcdA (PubMed 15854646, PubMed 1324324, PubMed 8254658, PubMed 8604132). {ECO 0000269|PubMed 12051842, ECO 0000269|PubMed 1324324, ECO 0000269|PubMed 15854646, ECO 0000269|PubMed 18642932, ECO 0000269|PubMed 19965760, ECO 0000269|PubMed 8254658, ECO 0000269|PubMed 8604132, ECO 0000269|PubMed 9148951}. # SUPFAM SSF56719 SSF56719 # eggNOG COG0188 LUCA # eggNOG ENOG4105C24 Bacteria BLAST swissprot:GYRA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GYRA_ECOLI BioCyc ECOL316407:JW2225-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2225-MONOMER BioCyc EcoCyc:EG10423-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10423-MONOMER BioCyc MetaCyc:EG10423-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10423-MONOMER COG COG0188 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0188 DIP DIP-36179N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36179N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/jmbi.1993.1609 http://dx.doi.org/10.1006/jmbi.1993.1609 DOI 10.1006/jmbi.1996.0102 http://dx.doi.org/10.1006/jmbi.1996.0102 DOI 10.1007/BF00338386 http://dx.doi.org/10.1007/BF00338386 DOI 10.1016/0022-2836(87)90479-7 http://dx.doi.org/10.1016/0022-2836(87)90479-7 DOI 10.1016/0022-2836(92)90629-X http://dx.doi.org/10.1016/0022-2836(92)90629-X DOI 10.1016/S0022-2836(02)00048-7 http://dx.doi.org/10.1016/S0022-2836(02)00048-7 DOI 10.1016/j.bmcl.2010.03.052 http://dx.doi.org/10.1016/j.bmcl.2010.03.052 DOI 10.1016/j.bmcl.2012.11.073 http://dx.doi.org/10.1016/j.bmcl.2012.11.073 DOI 10.1016/j.jmb.2005.03.049 http://dx.doi.org/10.1016/j.jmb.2005.03.049 DOI 10.1021/bi800480j http://dx.doi.org/10.1021/bi800480j DOI 10.1038/42294 http://dx.doi.org/10.1038/42294 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1997.6242005.x http://dx.doi.org/10.1046/j.1365-2958.1997.6242005.x DOI 10.1073/pnas.73.11.3872 http://dx.doi.org/10.1073/pnas.73.11.3872 DOI 10.1073/pnas.74.11.4772 http://dx.doi.org/10.1073/pnas.74.11.4772 DOI 10.1073/pnas.93.25.14416 http://dx.doi.org/10.1073/pnas.93.25.14416 DOI 10.1074/jbc.272.20.13302 http://dx.doi.org/10.1074/jbc.272.20.13302 DOI 10.1074/jbc.M112.345678 http://dx.doi.org/10.1074/jbc.M112.345678 DOI 10.1074/jbc.M112.345736 http://dx.doi.org/10.1074/jbc.M112.345736 DOI 10.1074/jbc.M502838200 http://dx.doi.org/10.1074/jbc.M502838200 DOI 10.1074/jbc.M511160200 http://dx.doi.org/10.1074/jbc.M511160200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1101/gad.11.19.2580 http://dx.doi.org/10.1101/gad.11.19.2580 DOI 10.1111/j.1365-2958.1987.tb01932.x http://dx.doi.org/10.1111/j.1365-2958.1987.tb01932.x DOI 10.1126/science.1179123 http://dx.doi.org/10.1126/science.1179123 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AAC.33.6.886 http://dx.doi.org/10.1128/AAC.33.6.886 DOI 10.1128/AAC.34.6.1271 http://dx.doi.org/10.1128/AAC.34.6.1271 DOI 10.1128/AAC.35.2.335 http://dx.doi.org/10.1128/AAC.35.2.335 DOI 10.1128/AAC.35.2.387 http://dx.doi.org/10.1128/AAC.35.2.387 DOI 10.1128/AAC.38.9.1966 http://dx.doi.org/10.1128/AAC.38.9.1966 DOI 10.1128/JB.00083-07 http://dx.doi.org/10.1128/JB.00083-07 DOI 10.1128/JB.01205-08 http://dx.doi.org/10.1128/JB.01205-08 DrugBank DB00537 http://www.drugbank.ca/drugs/DB00537 EC_number EC:5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_01897, ECO:0000269|PubMed:12051842, ECO:0000269|PubMed:18642932, ECO:0000269|PubMed:186775, ECO:0000269|PubMed:19965760, ECO:0000269|PubMed:9278055} http://www.genome.jp/dbget-bin/www_bget?EC:5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_01897, ECO:0000269|PubMed:12051842, ECO:0000269|PubMed:18642932, ECO:0000269|PubMed:186775, ECO:0000269|PubMed:19965760, ECO:0000269|PubMed:9278055} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M15631 http://www.ebi.ac.uk/ena/data/view/M15631 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X06373 http://www.ebi.ac.uk/ena/data/view/X06373 EMBL X06744 http://www.ebi.ac.uk/ena/data/view/X06744 EMBL Y00544 http://www.ebi.ac.uk/ena/data/view/Y00544 ENZYME 5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_01897, ECO:0000269|PubMed:12051842, ECO:0000269|PubMed:18642932, ECO:0000269|PubMed:186775, ECO:0000269|PubMed:19965760, ECO:0000269|PubMed:9278055} http://enzyme.expasy.org/EC/5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_01897, ECO:0000269|PubMed:12051842, ECO:0000269|PubMed:18642932, ECO:0000269|PubMed:186775, ECO:0000269|PubMed:19965760, ECO:0000269|PubMed:9278055} EchoBASE EB0418 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0418 EcoGene EG10423 http://www.ecogene.org/geneInfo.php?eg_id=EG10423 EnsemblBacteria AAC75291 http://www.ensemblgenomes.org/id/AAC75291 EnsemblBacteria AAC75291 http://www.ensemblgenomes.org/id/AAC75291 EnsemblBacteria BAA16048 http://www.ensemblgenomes.org/id/BAA16048 EnsemblBacteria BAA16048 http://www.ensemblgenomes.org/id/BAA16048 EnsemblBacteria BAA16048 http://www.ensemblgenomes.org/id/BAA16048 EnsemblBacteria b2231 http://www.ensemblgenomes.org/id/b2231 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005694 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005694 GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0009295 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009295 GO_component GO:0009330 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009330 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003918 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003918 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008094 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008094 GO_function GO:0034335 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034335 GO_process GO:0006265 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006265 GO_process GO:0006268 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006268 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0007059 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007059 GO_process GO:0042493 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005694 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005694 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0007059 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007059 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0051276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051276 Gene3D 1.10.268.10 http://www.cathdb.info/version/latest/superfamily/1.10.268.10 Gene3D 3.30.1360.40 http://www.cathdb.info/version/latest/superfamily/3.30.1360.40 Gene3D 3.90.199.10 http://www.cathdb.info/version/latest/superfamily/3.90.199.10 GeneID 946614 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946614 HAMAP MF_01897 http://hamap.expasy.org/unirule/MF_01897 HOGENOM HOG000076278 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000076278&db=HOGENOM6 InParanoid P0AES4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AES4 IntAct P0AES4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AES4* IntEnz 5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_01897, ECO:0000269|PubMed:12051842, ECO:0000269|PubMed:18642932, ECO:0000269|PubMed:186775, ECO:0000269|PubMed:19965760, ECO:0000269|PubMed:9278055} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_01897, ECO:0000269|PubMed:12051842, ECO:0000269|PubMed:18642932, ECO:0000269|PubMed:186775, ECO:0000269|PubMed:19965760, ECO:0000269|PubMed:9278055} InterPro IPR002205 http://www.ebi.ac.uk/interpro/entry/IPR002205 InterPro IPR005743 http://www.ebi.ac.uk/interpro/entry/IPR005743 InterPro IPR006691 http://www.ebi.ac.uk/interpro/entry/IPR006691 InterPro IPR013757 http://www.ebi.ac.uk/interpro/entry/IPR013757 InterPro IPR013758 http://www.ebi.ac.uk/interpro/entry/IPR013758 InterPro IPR013760 http://www.ebi.ac.uk/interpro/entry/IPR013760 InterPro IPR024946 http://www.ebi.ac.uk/interpro/entry/IPR024946 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03032 http://www.genome.jp/dbget-bin/www_bget?ko03032 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW2225 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2225 KEGG_Gene eco:b2231 http://www.genome.jp/dbget-bin/www_bget?eco:b2231 KEGG_Orthology KO:K02469 http://www.genome.jp/dbget-bin/www_bget?KO:K02469 MINT MINT-201682 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-201682 OMA EMKSAYI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EMKSAYI PDB 1AB4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1AB4 PDB 1X75 http://www.ebi.ac.uk/pdbe-srv/view/entry/1X75 PDB 1ZI0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZI0 PDB 2Y3P http://www.ebi.ac.uk/pdbe-srv/view/entry/2Y3P PDB 3NUH http://www.ebi.ac.uk/pdbe-srv/view/entry/3NUH PDB 4ELY http://www.ebi.ac.uk/pdbe-srv/view/entry/4ELY PDBsum 1AB4 http://www.ebi.ac.uk/pdbsum/1AB4 PDBsum 1X75 http://www.ebi.ac.uk/pdbsum/1X75 PDBsum 1ZI0 http://www.ebi.ac.uk/pdbsum/1ZI0 PDBsum 2Y3P http://www.ebi.ac.uk/pdbsum/2Y3P PDBsum 3NUH http://www.ebi.ac.uk/pdbsum/3NUH PDBsum 4ELY http://www.ebi.ac.uk/pdbsum/4ELY PSORT swissprot:GYRA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GYRA_ECOLI PSORT-B swissprot:GYRA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GYRA_ECOLI PSORT2 swissprot:GYRA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GYRA_ECOLI Pfam PF00521 http://pfam.xfam.org/family/PF00521 Pfam PF03989 http://pfam.xfam.org/family/PF03989 Phobius swissprot:GYRA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GYRA_ECOLI PhylomeDB P0AES4 http://phylomedb.org/?seqid=P0AES4 ProteinModelPortal P0AES4 http://www.proteinmodelportal.org/query/uniprot/P0AES4 PubMed 12051842 http://www.ncbi.nlm.nih.gov/pubmed/12051842 PubMed 1324324 http://www.ncbi.nlm.nih.gov/pubmed/1324324 PubMed 15854646 http://www.ncbi.nlm.nih.gov/pubmed/15854646 PubMed 15897198 http://www.ncbi.nlm.nih.gov/pubmed/15897198 PubMed 16332690 http://www.ncbi.nlm.nih.gov/pubmed/16332690 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17400739 http://www.ncbi.nlm.nih.gov/pubmed/17400739 PubMed 1850970 http://www.ncbi.nlm.nih.gov/pubmed/1850970 PubMed 1850972 http://www.ncbi.nlm.nih.gov/pubmed/1850972 PubMed 18642932 http://www.ncbi.nlm.nih.gov/pubmed/18642932 PubMed 186775 http://www.ncbi.nlm.nih.gov/pubmed/186775 PubMed 19060136 http://www.ncbi.nlm.nih.gov/pubmed/19060136 PubMed 19965760 http://www.ncbi.nlm.nih.gov/pubmed/19965760 PubMed 20356737 http://www.ncbi.nlm.nih.gov/pubmed/20356737 PubMed 2168148 http://www.ncbi.nlm.nih.gov/pubmed/2168148 PubMed 22457352 http://www.ncbi.nlm.nih.gov/pubmed/22457352 PubMed 22457353 http://www.ncbi.nlm.nih.gov/pubmed/22457353 PubMed 23294697 http://www.ncbi.nlm.nih.gov/pubmed/23294697 PubMed 2548439 http://www.ncbi.nlm.nih.gov/pubmed/2548439 PubMed 2828631 http://www.ncbi.nlm.nih.gov/pubmed/2828631 PubMed 2830458 http://www.ncbi.nlm.nih.gov/pubmed/2830458 PubMed 2834621 http://www.ncbi.nlm.nih.gov/pubmed/2834621 PubMed 3029031 http://www.ncbi.nlm.nih.gov/pubmed/3029031 PubMed 3031051 http://www.ncbi.nlm.nih.gov/pubmed/3031051 PubMed 337300 http://www.ncbi.nlm.nih.gov/pubmed/337300 PubMed 7811004 http://www.ncbi.nlm.nih.gov/pubmed/7811004 PubMed 8254658 http://www.ncbi.nlm.nih.gov/pubmed/8254658 PubMed 8604132 http://www.ncbi.nlm.nih.gov/pubmed/8604132 PubMed 8962066 http://www.ncbi.nlm.nih.gov/pubmed/8962066 PubMed 9148951 http://www.ncbi.nlm.nih.gov/pubmed/9148951 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278055 http://www.ncbi.nlm.nih.gov/pubmed/9278055 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9334322 http://www.ncbi.nlm.nih.gov/pubmed/9334322 PubMed 9426128 http://www.ncbi.nlm.nih.gov/pubmed/9426128 RefSeq NP_416734 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416734 RefSeq WP_001281242 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001281242 SMART SM00434 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00434 SMR P0AES4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AES4 STRING 511145.b2231 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2231&targetmode=cogs STRING COG0188 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0188&targetmode=cogs SUPFAM SSF56719 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56719 SWISS-2DPAGE P0AES4 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AES4 UniProtKB GYRA_ECOLI http://www.uniprot.org/uniprot/GYRA_ECOLI UniProtKB-AC P0AES4 http://www.uniprot.org/uniprot/P0AES4 charge swissprot:GYRA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GYRA_ECOLI eggNOG COG0188 http://eggnogapi.embl.de/nog_data/html/tree/COG0188 eggNOG ENOG4105C24 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C24 epestfind swissprot:GYRA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GYRA_ECOLI garnier swissprot:GYRA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GYRA_ECOLI helixturnhelix swissprot:GYRA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GYRA_ECOLI hmoment swissprot:GYRA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GYRA_ECOLI iep swissprot:GYRA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GYRA_ECOLI inforesidue swissprot:GYRA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GYRA_ECOLI octanol swissprot:GYRA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GYRA_ECOLI pepcoil swissprot:GYRA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GYRA_ECOLI pepdigest swissprot:GYRA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GYRA_ECOLI pepinfo swissprot:GYRA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GYRA_ECOLI pepnet swissprot:GYRA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GYRA_ECOLI pepstats swissprot:GYRA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GYRA_ECOLI pepwheel swissprot:GYRA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GYRA_ECOLI pepwindow swissprot:GYRA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GYRA_ECOLI sigcleave swissprot:GYRA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GYRA_ECOLI ## Database ID URL or Descriptions # BioGrid 4263502 9 # CATALYTIC ACTIVITY TORZ_ECOLI Trimethylamine + 2 (ferricytochrome c)-subunit + H(2)O = trimethylamine N-oxide + 2 (ferrocytochrome c)-subunit + 2 H(+). # CAUTION Was originally thought to be a biotin sulfoxide reductase. {ECO:0000305|PubMed 8919859}. # COFACTOR TORZ_ECOLI Name=Mo-bis(molybdopterin guanine dinucleotide); Xref=ChEBI CHEBI 60539; Evidence={ECO 0000250}; Note=Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit. {ECO 0000250}; # EcoGene EG13276 torZ # FUNCTION TORZ_ECOLI Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions. Can also reduce other N- and S-oxide compounds such as 4-methylmorpholine-N-oxide and biotin sulfoxide (BSO), but with a lower catalytic efficiency. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0009055 electron carrier activity; IEA:InterPro. # GO_function GO:0030151 molybdenum ion binding; IEA:InterPro. # GO_function GO:0050626 trimethylamine-N-oxide reductase (cytochrome c) activity; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # IntAct P46923 6 # InterPro IPR006311 TAT_signal # InterPro IPR006655 Mopterin_OxRdtase_prok_CS # InterPro IPR006656 Mopterin_OxRdtase # InterPro IPR006657 MoPterin_dinucl-bd_dom # InterPro IPR006658 BisC # InterPro IPR009010 Asp_de-COase-like_dom # InterPro IPR019546 TAT_signal_bac_arc # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 Transporters # MISCELLANEOUS TORZ_ECOLI Expression of torYZ allows E.coli to grow anaerobically on a wider range of substrates than does expression of torCAD. # Organism TORZ_ECOLI Escherichia coli (strain K12) # PATRIC 32119069 VBIEscCol129921_1952 # PIR H64949 H64949 # PROSITE PS00490 MOLYBDOPTERIN_PROK_2 # PROSITE PS00932 MOLYBDOPTERIN_PROK_3 # PROSITE PS51318 TAT # PTM TORZ_ECOLI Exported by the Tat system. The position of the signal peptide cleavage has been experimentally proven. Can also be exported by the Sec system. # Pfam PF00384 Molybdopterin # Pfam PF01568 Molydop_binding # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TORZ_ECOLI Trimethylamine-N-oxide reductase 2 # RefSeq NP_416386 NC_000913.3 # RefSeq WP_000176781 NZ_LN832404.1 # SIMILARITY Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. {ECO 0000305}. # SUBCELLULAR LOCATION TORZ_ECOLI Periplasm. # SUPFAM SSF50692 SSF50692 # TIGRFAMs TIGR00509 bisC_fam # TIGRFAMs TIGR01409 TAT_signal_seq # eggNOG COG0243 LUCA # eggNOG ENOG4107QY8 Bacteria BLAST swissprot:TORZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TORZ_ECOLI BioCyc ECOL316407:JW1861-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1861-MONOMER BioCyc EcoCyc:G7022-MONOMER http://biocyc.org/getid?id=EcoCyc:G7022-MONOMER BioCyc MetaCyc:G7022-MONOMER http://biocyc.org/getid?id=MetaCyc:G7022-MONOMER COG COG0243 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0243 DIP DIP-9226N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9226N DOI 10.1007/BF02198832 http://dx.doi.org/10.1007/BF02198832 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M610507200 http://dx.doi.org/10.1074/jbc.M610507200 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.20.5779-5786.2000 http://dx.doi.org/10.1128/JB.182.20.5779-5786.2000 EC_number EC:1.7.2.3 http://www.genome.jp/dbget-bin/www_bget?EC:1.7.2.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U38839 http://www.ebi.ac.uk/ena/data/view/U38839 ENZYME 1.7.2.3 http://enzyme.expasy.org/EC/1.7.2.3 EchoBASE EB3061 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3061 EcoGene EG13276 http://www.ecogene.org/geneInfo.php?eg_id=EG13276 EnsemblBacteria AAC74942 http://www.ensemblgenomes.org/id/AAC74942 EnsemblBacteria AAC74942 http://www.ensemblgenomes.org/id/AAC74942 EnsemblBacteria BAA15682 http://www.ensemblgenomes.org/id/BAA15682 EnsemblBacteria BAA15682 http://www.ensemblgenomes.org/id/BAA15682 EnsemblBacteria BAA15682 http://www.ensemblgenomes.org/id/BAA15682 EnsemblBacteria b1872 http://www.ensemblgenomes.org/id/b1872 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0030151 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030151 GO_function GO:0050626 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050626 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GeneID 946389 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946389 HOGENOM HOG000284391 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000284391&db=HOGENOM6 InParanoid P46923 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P46923 IntAct P46923 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P46923* IntEnz 1.7.2.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.7.2.3 InterPro IPR006311 http://www.ebi.ac.uk/interpro/entry/IPR006311 InterPro IPR006655 http://www.ebi.ac.uk/interpro/entry/IPR006655 InterPro IPR006656 http://www.ebi.ac.uk/interpro/entry/IPR006656 InterPro IPR006657 http://www.ebi.ac.uk/interpro/entry/IPR006657 InterPro IPR006658 http://www.ebi.ac.uk/interpro/entry/IPR006658 InterPro IPR009010 http://www.ebi.ac.uk/interpro/entry/IPR009010 InterPro IPR019546 http://www.ebi.ac.uk/interpro/entry/IPR019546 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1861 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1861 KEGG_Gene eco:b1872 http://www.genome.jp/dbget-bin/www_bget?eco:b1872 KEGG_Orthology KO:K07812 http://www.genome.jp/dbget-bin/www_bget?KO:K07812 OMA HGEQTHW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HGEQTHW PROSITE PS00490 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00490 PROSITE PS00932 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00932 PROSITE PS51318 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51318 PSORT swissprot:TORZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TORZ_ECOLI PSORT-B swissprot:TORZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TORZ_ECOLI PSORT2 swissprot:TORZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TORZ_ECOLI Pfam PF00384 http://pfam.xfam.org/family/PF00384 Pfam PF01568 http://pfam.xfam.org/family/PF01568 Phobius swissprot:TORZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TORZ_ECOLI PhylomeDB P46923 http://phylomedb.org/?seqid=P46923 ProteinModelPortal P46923 http://www.proteinmodelportal.org/query/uniprot/P46923 PubMed 11004177 http://www.ncbi.nlm.nih.gov/pubmed/11004177 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17218314 http://www.ncbi.nlm.nih.gov/pubmed/17218314 PubMed 8919859 http://www.ncbi.nlm.nih.gov/pubmed/8919859 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416386 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416386 RefSeq WP_000176781 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000176781 SMR P46923 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P46923 STRING 511145.b1872 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1872&targetmode=cogs STRING COG0243 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0243&targetmode=cogs SUPFAM SSF50692 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50692 TIGRFAMs TIGR00509 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00509 TIGRFAMs TIGR01409 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01409 UniProtKB TORZ_ECOLI http://www.uniprot.org/uniprot/TORZ_ECOLI UniProtKB-AC P46923 http://www.uniprot.org/uniprot/P46923 charge swissprot:TORZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TORZ_ECOLI eggNOG COG0243 http://eggnogapi.embl.de/nog_data/html/tree/COG0243 eggNOG ENOG4107QY8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QY8 epestfind swissprot:TORZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TORZ_ECOLI garnier swissprot:TORZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TORZ_ECOLI helixturnhelix swissprot:TORZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TORZ_ECOLI hmoment swissprot:TORZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TORZ_ECOLI iep swissprot:TORZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TORZ_ECOLI inforesidue swissprot:TORZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TORZ_ECOLI octanol swissprot:TORZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TORZ_ECOLI pepcoil swissprot:TORZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TORZ_ECOLI pepdigest swissprot:TORZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TORZ_ECOLI pepinfo swissprot:TORZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TORZ_ECOLI pepnet swissprot:TORZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TORZ_ECOLI pepstats swissprot:TORZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TORZ_ECOLI pepwheel swissprot:TORZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TORZ_ECOLI pepwindow swissprot:TORZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TORZ_ECOLI sigcleave swissprot:TORZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TORZ_ECOLI ## Database ID URL or Descriptions # AltName PAAA_ECOLI 1,2-phenylacetyl-CoA epoxidase, catalytic subunit alpha # AltName PAAA_ECOLI 1,2-phenylacetyl-CoA monooxygenase, subunit A # BioGrid 4261392 123 # CATALYTIC ACTIVITY Phenylacetyl-CoA + NADPH + O(2) = 2-(1,2- epoxy-1,2-dihydrophenyl)acetyl-CoA + NADP(+) + H(2)O. {ECO:0000269|PubMed 20660314}. # COFACTOR Name=Fe cation; Xref=ChEBI:CHEBI 24875; Evidence={ECO:0000305}; # EcoGene EG13736 paaA # FUNCTION PAAA_ECOLI Component of 1,2-phenylacetyl-CoA epoxidase multicomponent enzyme system which catalyzes the reduction of phenylacetyl-CoA (PA-CoA) to form 1,2-epoxyphenylacetyl-CoA. The subunit A is the catalytic subunit involved in the incorporation of one atom of molecular oxygen into phenylacetyl-CoA. {ECO 0000269|PubMed 16997993, ECO 0000269|PubMed 20660314, ECO 0000269|PubMed 21247899, ECO 0000269|PubMed 9748275}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0097266 phenylacetyl-CoA 1,2-epoxidase activity; IEA:UniProtKB-EC. # GO_process GO:0010124 phenylacetate catabolic process; IMP:UniProtKB. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.20.1260.10 -; 1. # INDUCTION PAAA_ECOLI Activated by cAMP receptor protein (CRP), integration host factor (IHF) and by phenylacetyl-coenzyme A (PA-CoA) that prevents PaaX from binding its target sequences. Inhibited by PaaX. {ECO 0000269|PubMed 10766858, ECO 0000269|PubMed 9748275}. # InterPro IPR007814 PaaA_PaaC # InterPro IPR009078 Ferritin-like_SF # InterPro IPR011881 PaaA # InterPro IPR012347 Ferritin-rel # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00360 Phenylalanine metabolism # Organism PAAA_ECOLI Escherichia coli (strain K12) # PATHWAY PAAA_ECOLI Aromatic compound metabolism; phenylacetate degradation. # PATRIC 32118062 VBIEscCol129921_1451 # PDB 3PVR X-ray; 2.10 A; A=2-309 # PDB 3PVT X-ray; 2.03 A; A=2-309 # PDB 3PVY X-ray; 2.15 A; A=2-309 # PDB 3PW1 X-ray; 2.25 A; A=2-309 # PDB 3PW8 X-ray; 2.97 A; C/D=2-309 # PDB 3PWQ X-ray; 2.65 A; C/D/F/H=2-309 # PDB 4II4 X-ray; 2.80 A; A=2-309 # PIR G64889 G64889 # Pfam PF05138 PaaA_PaaC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PAAA_ECOLI 1,2-phenylacetyl-CoA epoxidase, subunit A # RefSeq NP_415906 NC_000913.3 # RefSeq WP_000191077 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA66090.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SUBUNIT PAAA_ECOLI Forms a stable heterotetramer (dimer of heterodimers) with PaaC. {ECO 0000269|PubMed 20823522, ECO 0000269|PubMed 21247899}. # SUPFAM SSF47240 SSF47240 # TIGRFAMs TIGR02156 PA_CoA_Oxy1 # eggNOG COG3396 LUCA # eggNOG ENOG4105CRS Bacteria BLAST swissprot:PAAA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PAAA_ECOLI BioCyc ECOL316407:JW1383-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1383-MONOMER BioCyc EcoCyc:G6709-MONOMER http://biocyc.org/getid?id=EcoCyc:G6709-MONOMER BioCyc MetaCyc:G6709-MONOMER http://biocyc.org/getid?id=MetaCyc:G6709-MONOMER COG COG3396 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3396 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.1005399107 http://dx.doi.org/10.1073/pnas.1005399107 DOI 10.1074/jbc.273.40.25974 http://dx.doi.org/10.1074/jbc.273.40.25974 DOI 10.1074/jbc.275.16.12214 http://dx.doi.org/10.1074/jbc.275.16.12214 DOI 10.1074/jbc.M110.194423 http://dx.doi.org/10.1074/jbc.M110.194423 DOI 10.1107/S174430911002748X http://dx.doi.org/10.1107/S174430911002748X DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AEM.01550-06 http://dx.doi.org/10.1128/AEM.01550-06 EC_number EC:1.14.13.149 http://www.genome.jp/dbget-bin/www_bget?EC:1.14.13.149 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X97452 http://www.ebi.ac.uk/ena/data/view/X97452 ENZYME 1.14.13.149 http://enzyme.expasy.org/EC/1.14.13.149 EchoBASE EB3499 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3499 EcoGene EG13736 http://www.ecogene.org/geneInfo.php?eg_id=EG13736 EnsemblBacteria AAC74470 http://www.ensemblgenomes.org/id/AAC74470 EnsemblBacteria AAC74470 http://www.ensemblgenomes.org/id/AAC74470 EnsemblBacteria BAE76423 http://www.ensemblgenomes.org/id/BAE76423 EnsemblBacteria BAE76423 http://www.ensemblgenomes.org/id/BAE76423 EnsemblBacteria BAE76423 http://www.ensemblgenomes.org/id/BAE76423 EnsemblBacteria b1388 http://www.ensemblgenomes.org/id/b1388 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0097266 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097266 GO_process GO:0010124 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010124 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.20.1260.10 http://www.cathdb.info/version/latest/superfamily/1.20.1260.10 GeneID 945833 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945833 HOGENOM HOG000249745 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000249745&db=HOGENOM6 InParanoid P76077 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76077 IntAct P76077 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76077* IntEnz 1.14.13.149 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.14.13.149 InterPro IPR007814 http://www.ebi.ac.uk/interpro/entry/IPR007814 InterPro IPR009078 http://www.ebi.ac.uk/interpro/entry/IPR009078 InterPro IPR011881 http://www.ebi.ac.uk/interpro/entry/IPR011881 InterPro IPR012347 http://www.ebi.ac.uk/interpro/entry/IPR012347 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1383 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1383 KEGG_Gene eco:b1388 http://www.genome.jp/dbget-bin/www_bget?eco:b1388 KEGG_Orthology KO:K02609 http://www.genome.jp/dbget-bin/www_bget?KO:K02609 KEGG_Pathway ko00360 http://www.genome.jp/kegg-bin/show_pathway?ko00360 KEGG_Reaction rn:R09838 http://www.genome.jp/dbget-bin/www_bget?rn:R09838 OMA QPEANWI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QPEANWI PDB 3PVR http://www.ebi.ac.uk/pdbe-srv/view/entry/3PVR PDB 3PVT http://www.ebi.ac.uk/pdbe-srv/view/entry/3PVT PDB 3PVY http://www.ebi.ac.uk/pdbe-srv/view/entry/3PVY PDB 3PW1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3PW1 PDB 3PW8 http://www.ebi.ac.uk/pdbe-srv/view/entry/3PW8 PDB 3PWQ http://www.ebi.ac.uk/pdbe-srv/view/entry/3PWQ PDB 4II4 http://www.ebi.ac.uk/pdbe-srv/view/entry/4II4 PDBsum 3PVR http://www.ebi.ac.uk/pdbsum/3PVR PDBsum 3PVT http://www.ebi.ac.uk/pdbsum/3PVT PDBsum 3PVY http://www.ebi.ac.uk/pdbsum/3PVY PDBsum 3PW1 http://www.ebi.ac.uk/pdbsum/3PW1 PDBsum 3PW8 http://www.ebi.ac.uk/pdbsum/3PW8 PDBsum 3PWQ http://www.ebi.ac.uk/pdbsum/3PWQ PDBsum 4II4 http://www.ebi.ac.uk/pdbsum/4II4 PSORT swissprot:PAAA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PAAA_ECOLI PSORT-B swissprot:PAAA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PAAA_ECOLI PSORT2 swissprot:PAAA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PAAA_ECOLI Pfam PF05138 http://pfam.xfam.org/family/PF05138 Phobius swissprot:PAAA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PAAA_ECOLI PhylomeDB P76077 http://phylomedb.org/?seqid=P76077 ProteinModelPortal P76077 http://www.proteinmodelportal.org/query/uniprot/P76077 PubMed 10766858 http://www.ncbi.nlm.nih.gov/pubmed/10766858 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16997993 http://www.ncbi.nlm.nih.gov/pubmed/16997993 PubMed 20660314 http://www.ncbi.nlm.nih.gov/pubmed/20660314 PubMed 20823522 http://www.ncbi.nlm.nih.gov/pubmed/20823522 PubMed 21247899 http://www.ncbi.nlm.nih.gov/pubmed/21247899 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9748275 http://www.ncbi.nlm.nih.gov/pubmed/9748275 RefSeq NP_415906 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415906 RefSeq WP_000191077 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000191077 SMR P76077 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76077 STRING 511145.b1388 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1388&targetmode=cogs STRING COG3396 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3396&targetmode=cogs SUPFAM SSF47240 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47240 TIGRFAMs TIGR02156 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02156 UniProtKB PAAA_ECOLI http://www.uniprot.org/uniprot/PAAA_ECOLI UniProtKB-AC P76077 http://www.uniprot.org/uniprot/P76077 charge swissprot:PAAA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PAAA_ECOLI eggNOG COG3396 http://eggnogapi.embl.de/nog_data/html/tree/COG3396 eggNOG ENOG4105CRS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CRS epestfind swissprot:PAAA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PAAA_ECOLI garnier swissprot:PAAA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PAAA_ECOLI helixturnhelix swissprot:PAAA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PAAA_ECOLI hmoment swissprot:PAAA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PAAA_ECOLI iep swissprot:PAAA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PAAA_ECOLI inforesidue swissprot:PAAA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PAAA_ECOLI octanol swissprot:PAAA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PAAA_ECOLI pepcoil swissprot:PAAA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PAAA_ECOLI pepdigest swissprot:PAAA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PAAA_ECOLI pepinfo swissprot:PAAA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PAAA_ECOLI pepnet swissprot:PAAA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PAAA_ECOLI pepstats swissprot:PAAA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PAAA_ECOLI pepwheel swissprot:PAAA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PAAA_ECOLI pepwindow swissprot:PAAA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PAAA_ECOLI sigcleave swissprot:PAAA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PAAA_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES UBIC_ECOLI Kinetic parameters KM=6.1 uM for chorismate {ECO 0000269|PubMed 8012607}; KM=29 uM for chorismate {ECO 0000269|PubMed 11825618}; pH dependence Optimum pH is 7.5. {ECO 0000269|PubMed 11825618, ECO 0000269|PubMed 8012607}; # BRENDA 4.1.3.40 2026 # BioGrid 4262658 210 # CATALYTIC ACTIVITY UBIC_ECOLI Chorismate = 4-hydroxybenzoate + pyruvate. {ECO 0000269|PubMed 11825618, ECO 0000269|PubMed 8012607}. # ENZYME REGULATION UBIC_ECOLI Inhibited by 4-hydroxybenzoate, vanillate, 4- hydroxybenzaldehyde and 3-carboxymethylaminomethyl-4- hydroxybenzoic acid. {ECO 0000269|PubMed 11825618, ECO 0000269|PubMed 16343413}. # EcoGene EG11369 ubiC # FUNCTION UBIC_ECOLI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway. {ECO 0000269|PubMed 11825618, ECO 0000269|PubMed 16343413, ECO 0000269|PubMed 1644758, ECO 0000269|PubMed 8012607}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008813 chorismate lyase activity; IDA:EcoCyc. # GO_process GO:0006744 ubiquinone biosynthetic process; IMP:EcoCyc. # GO_process GO:0042866 pyruvate biosynthetic process; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.1410.10 -; 1. # HAMAP MF_01632 UbiC # IntAct P26602 3 # InterPro IPR007440 Chorismate--pyruvate_lyase # InterPro IPR028978 Chorismate_lyase_/UTRA_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00130 Ubiquinone and other terpenoid-quinone biosynthesis # Organism UBIC_ECOLI Escherichia coli (strain K12) # PATHWAY UBIC_ECOLI Cofactor biosynthesis; ubiquinone biosynthesis. # PATRIC 32123615 VBIEscCol129921_4156 # PDB 1FW9 X-ray; 1.40 A; A=2-165 # PDB 1G1B X-ray; 1.99 A; A/B=2-165 # PDB 1G81 X-ray; 1.71 A; A=2-165 # PDB 1JD3 X-ray; 2.03 A; A=2-165 # PDB 1TT8 X-ray; 1.00 A; A=2-165 # PDB 1XLR X-ray; 1.94 A; A=2-165 # PDB 2AHC X-ray; 2.40 A; A/B/C/D=2-165 # PIR S25660 S25660 # Pfam PF04345 Chor_lyase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UBIC_ECOLI Chorismate pyruvate-lyase # RefSeq NP_418463 NC_000913.3 # RefSeq WP_001326644 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAC43133.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA40681.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the UbiC family. {ECO 0000305}. # SUBCELLULAR LOCATION UBIC_ECOLI Cytoplasm. # SUBUNIT UBIC_ECOLI Monomer. {ECO 0000269|PubMed 11455603, ECO 0000269|PubMed 16343413}. # SUPFAM SSF64288 SSF64288 # eggNOG COG3161 LUCA # eggNOG ENOG4105VEI Bacteria BLAST swissprot:UBIC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UBIC_ECOLI BioCyc ECOL316407:JW5713-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5713-MONOMER BioCyc EcoCyc:CHORPYRLY-MONOMER http://biocyc.org/getid?id=EcoCyc:CHORPYRLY-MONOMER BioCyc MetaCyc:CHORPYRLY-MONOMER http://biocyc.org/getid?id=MetaCyc:CHORPYRLY-MONOMER COG COG3161 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3161 DIP DIP-11066N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11066N DOI 10.1002/prot.1095 http://dx.doi.org/10.1002/prot.1095 DOI 10.1006/jsbi.1999.4205 http://dx.doi.org/10.1006/jsbi.1999.4205 DOI 10.1016/0014-5793(92)80710-X http://dx.doi.org/10.1016/0014-5793(92)80710-X DOI 10.1016/S0167-4838(01)00302-8 http://dx.doi.org/10.1016/S0167-4838(01)00302-8 DOI 10.1016/j.abb.2005.10.026 http://dx.doi.org/10.1016/j.abb.2005.10.026 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1099/00221287-139-8-1795 http://dx.doi.org/10.1099/00221287-139-8-1795 DOI 10.1099/00221287-140-4-897 http://dx.doi.org/10.1099/00221287-140-4-897 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.1.3.40 {ECO:0000269|PubMed:11825618, ECO:0000269|PubMed:8012607} http://www.genome.jp/dbget-bin/www_bget?EC:4.1.3.40 {ECO:0000269|PubMed:11825618, ECO:0000269|PubMed:8012607} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL DQ087228 http://www.ebi.ac.uk/ena/data/view/DQ087228 EMBL M93136 http://www.ebi.ac.uk/ena/data/view/M93136 EMBL M93413 http://www.ebi.ac.uk/ena/data/view/M93413 EMBL M96268 http://www.ebi.ac.uk/ena/data/view/M96268 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X57434 http://www.ebi.ac.uk/ena/data/view/X57434 EMBL X66619 http://www.ebi.ac.uk/ena/data/view/X66619 ENZYME 4.1.3.40 {ECO:0000269|PubMed:11825618, ECO:0000269|PubMed:8012607} http://enzyme.expasy.org/EC/4.1.3.40 {ECO:0000269|PubMed:11825618, ECO:0000269|PubMed:8012607} EchoBASE EB1343 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1343 EcoGene EG11369 http://www.ecogene.org/geneInfo.php?eg_id=EG11369 EnsemblBacteria AAC77009 http://www.ensemblgenomes.org/id/AAC77009 EnsemblBacteria AAC77009 http://www.ensemblgenomes.org/id/AAC77009 EnsemblBacteria BAE78041 http://www.ensemblgenomes.org/id/BAE78041 EnsemblBacteria BAE78041 http://www.ensemblgenomes.org/id/BAE78041 EnsemblBacteria BAE78041 http://www.ensemblgenomes.org/id/BAE78041 EnsemblBacteria b4039 http://www.ensemblgenomes.org/id/b4039 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008813 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008813 GO_process GO:0006744 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006744 GO_process GO:0042866 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042866 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.1410.10 http://www.cathdb.info/version/latest/superfamily/3.40.1410.10 GeneID 948545 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948545 HAMAP MF_01632 http://hamap.expasy.org/unirule/MF_01632 HOGENOM HOG000137785 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000137785&db=HOGENOM6 InParanoid P26602 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P26602 IntAct P26602 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P26602* IntEnz 4.1.3.40 {ECO:0000269|PubMed:11825618, ECO:0000269|PubMed:8012607} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.3.40 {ECO:0000269|PubMed:11825618, ECO:0000269|PubMed:8012607} InterPro IPR007440 http://www.ebi.ac.uk/interpro/entry/IPR007440 InterPro IPR028978 http://www.ebi.ac.uk/interpro/entry/IPR028978 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5713 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5713 KEGG_Gene eco:b4039 http://www.genome.jp/dbget-bin/www_bget?eco:b4039 KEGG_Orthology KO:K03181 http://www.genome.jp/dbget-bin/www_bget?KO:K03181 KEGG_Pathway ko00130 http://www.genome.jp/kegg-bin/show_pathway?ko00130 KEGG_Reaction rn:R01302 http://www.genome.jp/dbget-bin/www_bget?rn:R01302 MINT MINT-1235748 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1235748 OMA ELWGRRS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ELWGRRS PDB 1FW9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1FW9 PDB 1G1B http://www.ebi.ac.uk/pdbe-srv/view/entry/1G1B PDB 1G81 http://www.ebi.ac.uk/pdbe-srv/view/entry/1G81 PDB 1JD3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1JD3 PDB 1TT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1TT8 PDB 1XLR http://www.ebi.ac.uk/pdbe-srv/view/entry/1XLR PDB 2AHC http://www.ebi.ac.uk/pdbe-srv/view/entry/2AHC PDBsum 1FW9 http://www.ebi.ac.uk/pdbsum/1FW9 PDBsum 1G1B http://www.ebi.ac.uk/pdbsum/1G1B PDBsum 1G81 http://www.ebi.ac.uk/pdbsum/1G81 PDBsum 1JD3 http://www.ebi.ac.uk/pdbsum/1JD3 PDBsum 1TT8 http://www.ebi.ac.uk/pdbsum/1TT8 PDBsum 1XLR http://www.ebi.ac.uk/pdbsum/1XLR PDBsum 2AHC http://www.ebi.ac.uk/pdbsum/2AHC PSORT swissprot:UBIC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UBIC_ECOLI PSORT-B swissprot:UBIC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UBIC_ECOLI PSORT2 swissprot:UBIC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UBIC_ECOLI Pfam PF04345 http://pfam.xfam.org/family/PF04345 Phobius swissprot:UBIC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UBIC_ECOLI ProteinModelPortal P26602 http://www.proteinmodelportal.org/query/uniprot/P26602 PubMed 10675300 http://www.ncbi.nlm.nih.gov/pubmed/10675300 PubMed 11455603 http://www.ncbi.nlm.nih.gov/pubmed/11455603 PubMed 11825618 http://www.ncbi.nlm.nih.gov/pubmed/11825618 PubMed 1512213 http://www.ncbi.nlm.nih.gov/pubmed/1512213 PubMed 16343413 http://www.ncbi.nlm.nih.gov/pubmed/16343413 PubMed 1644192 http://www.ncbi.nlm.nih.gov/pubmed/1644192 PubMed 1644758 http://www.ncbi.nlm.nih.gov/pubmed/1644758 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8012607 http://www.ncbi.nlm.nih.gov/pubmed/8012607 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 8409922 http://www.ncbi.nlm.nih.gov/pubmed/8409922 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418463 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418463 RefSeq WP_001326644 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001326644 SMR P26602 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P26602 STRING 511145.b4039 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4039&targetmode=cogs STRING COG3161 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3161&targetmode=cogs SUPFAM SSF64288 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF64288 UniProtKB UBIC_ECOLI http://www.uniprot.org/uniprot/UBIC_ECOLI UniProtKB-AC P26602 http://www.uniprot.org/uniprot/P26602 charge swissprot:UBIC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UBIC_ECOLI eggNOG COG3161 http://eggnogapi.embl.de/nog_data/html/tree/COG3161 eggNOG ENOG4105VEI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VEI epestfind swissprot:UBIC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UBIC_ECOLI garnier swissprot:UBIC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UBIC_ECOLI helixturnhelix swissprot:UBIC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UBIC_ECOLI hmoment swissprot:UBIC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UBIC_ECOLI iep swissprot:UBIC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UBIC_ECOLI inforesidue swissprot:UBIC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UBIC_ECOLI octanol swissprot:UBIC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UBIC_ECOLI pepcoil swissprot:UBIC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UBIC_ECOLI pepdigest swissprot:UBIC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UBIC_ECOLI pepinfo swissprot:UBIC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UBIC_ECOLI pepnet swissprot:UBIC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UBIC_ECOLI pepstats swissprot:UBIC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UBIC_ECOLI pepwheel swissprot:UBIC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UBIC_ECOLI pepwindow swissprot:UBIC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UBIC_ECOLI sigcleave swissprot:UBIC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UBIC_ECOLI ## Database ID URL or Descriptions # AltName TRMN6_ECOLI tRNA m6A37 methyltransferase # BRENDA 2.1.1.223 2026 # BioGrid 4260913 18 # CATALYTIC ACTIVITY S-adenosyl-L-methionine + adenine(37) in tRNA(1)(Val) = S-adenosyl-L-homocysteine + N(6)-methyladenine(37) in tRNA(1)(Val). {ECO:0000269|PubMed 19383770}. # DISRUPTION PHENOTYPE Cells lacking this gene show hypersensitivity to hyperosmotic and, to a lesser extent, oxidative stress. {ECO:0000269|PubMed 19383770}. # EcoGene EG11538 yfiC # FUNCTION TRMN6_ECOLI Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC). {ECO 0000269|PubMed 19383770}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003676 nucleic acid binding; IEA:InterPro. # GO_function GO:0016430 tRNA (adenine-N6-)-methyltransferase activity; IDA:EcoCyc. # GO_process GO:0030488 tRNA methylation; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0006399 tRNA metabolic process # Gene3D 3.40.50.150 -; 1. # HAMAP MF_01872 tRNA_methyltr_YfiC # IntAct P31825 4 # InterPro IPR002052 DNA_methylase_N6_adenine_CS # InterPro IPR007848 Small_mtfrase_dom # InterPro IPR022882 tRNA_adenine-N6_MeTrfase # InterPro IPR029063 SAM-dependent_MTases # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # Organism TRMN6_ECOLI Escherichia coli (strain K12) # PATRIC 32120549 VBIEscCol129921_2677 # PIR F65035 F65035 # PROSITE PS00092 N6_MTASE # Pfam PF05175 MTS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TRMN6_ECOLI tRNA1(Val) (adenine(37)-N6)-methyltransferase # RefSeq NP_417070 NC_000913.3 # RefSeq WP_001295363 NZ_LN832404.1 # SIMILARITY Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family. {ECO 0000305}. # SUBCELLULAR LOCATION TRMN6_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF53335 SSF53335 # eggNOG COG4123 LUCA # eggNOG ENOG4107S47 Bacteria BLAST swissprot:TRMN6_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRMN6_ECOLI BioCyc ECOL316407:JW2559-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2559-MONOMER BioCyc EcoCyc:EG11538-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11538-MONOMER BioCyc MetaCyc:EG11538-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11538-MONOMER COG COG04123 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG04123 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1261/rna.1494409 http://dx.doi.org/10.1261/rna.1494409 EC_number EC:2.1.1.223 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.223 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D13169 http://www.ebi.ac.uk/ena/data/view/D13169 EMBL D64044 http://www.ebi.ac.uk/ena/data/view/D64044 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.1.1.223 http://enzyme.expasy.org/EC/2.1.1.223 EchoBASE EB1500 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1500 EcoGene EG11538 http://www.ecogene.org/geneInfo.php?eg_id=EG11538 EnsemblBacteria AAC75628 http://www.ensemblgenomes.org/id/AAC75628 EnsemblBacteria AAC75628 http://www.ensemblgenomes.org/id/AAC75628 EnsemblBacteria BAE76751 http://www.ensemblgenomes.org/id/BAE76751 EnsemblBacteria BAE76751 http://www.ensemblgenomes.org/id/BAE76751 EnsemblBacteria BAE76751 http://www.ensemblgenomes.org/id/BAE76751 EnsemblBacteria b2575 http://www.ensemblgenomes.org/id/b2575 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003676 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003676 GO_function GO:0016430 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016430 GO_process GO:0030488 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030488 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 GeneID 947047 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947047 HAMAP MF_01872 http://hamap.expasy.org/unirule/MF_01872 HOGENOM HOG000283147 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000283147&db=HOGENOM6 InParanoid P31825 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31825 IntAct P31825 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31825* IntEnz 2.1.1.223 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.223 InterPro IPR002052 http://www.ebi.ac.uk/interpro/entry/IPR002052 InterPro IPR007848 http://www.ebi.ac.uk/interpro/entry/IPR007848 InterPro IPR022882 http://www.ebi.ac.uk/interpro/entry/IPR022882 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW2559 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2559 KEGG_Gene eco:b2575 http://www.genome.jp/dbget-bin/www_bget?eco:b2575 KEGG_Orthology KO:K15460 http://www.genome.jp/dbget-bin/www_bget?KO:K15460 OMA DRLFCYH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DRLFCYH PROSITE PS00092 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00092 PSORT swissprot:TRMN6_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRMN6_ECOLI PSORT-B swissprot:TRMN6_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRMN6_ECOLI PSORT2 swissprot:TRMN6_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRMN6_ECOLI Pfam PF05175 http://pfam.xfam.org/family/PF05175 Phobius swissprot:TRMN6_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRMN6_ECOLI ProteinModelPortal P31825 http://www.proteinmodelportal.org/query/uniprot/P31825 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19383770 http://www.ncbi.nlm.nih.gov/pubmed/19383770 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417070 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417070 RefSeq WP_001295363 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295363 STRING 511145.b2575 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2575&targetmode=cogs STRING COG04123 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG04123&targetmode=cogs SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 UniProtKB TRMN6_ECOLI http://www.uniprot.org/uniprot/TRMN6_ECOLI UniProtKB-AC P31825 http://www.uniprot.org/uniprot/P31825 charge swissprot:TRMN6_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRMN6_ECOLI eggNOG COG4123 http://eggnogapi.embl.de/nog_data/html/tree/COG4123 eggNOG ENOG4107S47 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107S47 epestfind swissprot:TRMN6_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRMN6_ECOLI garnier swissprot:TRMN6_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRMN6_ECOLI helixturnhelix swissprot:TRMN6_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRMN6_ECOLI hmoment swissprot:TRMN6_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRMN6_ECOLI iep swissprot:TRMN6_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRMN6_ECOLI inforesidue swissprot:TRMN6_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRMN6_ECOLI octanol swissprot:TRMN6_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRMN6_ECOLI pepcoil swissprot:TRMN6_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRMN6_ECOLI pepdigest swissprot:TRMN6_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRMN6_ECOLI pepinfo swissprot:TRMN6_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRMN6_ECOLI pepnet swissprot:TRMN6_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRMN6_ECOLI pepstats swissprot:TRMN6_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRMN6_ECOLI pepwheel swissprot:TRMN6_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRMN6_ECOLI pepwindow swissprot:TRMN6_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRMN6_ECOLI sigcleave swissprot:TRMN6_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRMN6_ECOLI ## Database ID URL or Descriptions # BioGrid 4261655 13 # EcoGene EG14160 yfeS # Gene3D 2.20.140.10 -; 1. # IntAct P78271 6 # InterPro IPR008893 WGR_domain # InterPro IPR016835 UCP026317_WGR # Organism YFES_ECOLI Escherichia coli (strain K12) # PATRIC 32120223 VBIEscCol129921_2514 # PIR C65016 C65016 # PIRSF PIRSF026317 UCP026317_WGR # Pfam PF05406 WGR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFES_ECOLI Uncharacterized protein YfeS # RefSeq NP_416915 NC_000913.3 # RefSeq WP_000745534 NZ_LN832404.1 # SMART SM00773 WGR # SUPFAM SSF142921 SSF142921 # eggNOG COG3831 LUCA # eggNOG COG4884 LUCA # eggNOG ENOG4105WEC Bacteria BLAST swissprot:YFES_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFES_ECOLI BioCyc ECOL316407:JW2413-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2413-MONOMER BioCyc EcoCyc:G7261-MONOMER http://biocyc.org/getid?id=EcoCyc:G7261-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3912 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3912 EcoGene EG14160 http://www.ecogene.org/geneInfo.php?eg_id=EG14160 EnsemblBacteria AAC75473 http://www.ensemblgenomes.org/id/AAC75473 EnsemblBacteria AAC75473 http://www.ensemblgenomes.org/id/AAC75473 EnsemblBacteria BAA16294 http://www.ensemblgenomes.org/id/BAA16294 EnsemblBacteria BAA16294 http://www.ensemblgenomes.org/id/BAA16294 EnsemblBacteria BAA16294 http://www.ensemblgenomes.org/id/BAA16294 EnsemblBacteria b2420 http://www.ensemblgenomes.org/id/b2420 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 2.20.140.10 http://www.cathdb.info/version/latest/superfamily/2.20.140.10 GeneID 946887 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946887 HOGENOM HOG000002402 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000002402&db=HOGENOM6 InParanoid P78271 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P78271 IntAct P78271 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P78271* InterPro IPR008893 http://www.ebi.ac.uk/interpro/entry/IPR008893 InterPro IPR016835 http://www.ebi.ac.uk/interpro/entry/IPR016835 KEGG_Gene ecj:JW2413 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2413 KEGG_Gene eco:b2420 http://www.genome.jp/dbget-bin/www_bget?eco:b2420 OMA DLETTHP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DLETTHP PSORT swissprot:YFES_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFES_ECOLI PSORT-B swissprot:YFES_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFES_ECOLI PSORT2 swissprot:YFES_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFES_ECOLI Pfam PF05406 http://pfam.xfam.org/family/PF05406 Phobius swissprot:YFES_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFES_ECOLI PhylomeDB P78271 http://phylomedb.org/?seqid=P78271 ProteinModelPortal P78271 http://www.proteinmodelportal.org/query/uniprot/P78271 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416915 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416915 RefSeq WP_000745534 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000745534 SMART SM00773 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00773 SMR P78271 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P78271 STRING 511145.b2420 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2420&targetmode=cogs SUPFAM SSF142921 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF142921 UniProtKB YFES_ECOLI http://www.uniprot.org/uniprot/YFES_ECOLI UniProtKB-AC P78271 http://www.uniprot.org/uniprot/P78271 charge swissprot:YFES_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFES_ECOLI eggNOG COG3831 http://eggnogapi.embl.de/nog_data/html/tree/COG3831 eggNOG COG4884 http://eggnogapi.embl.de/nog_data/html/tree/COG4884 eggNOG ENOG4105WEC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105WEC epestfind swissprot:YFES_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFES_ECOLI garnier swissprot:YFES_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFES_ECOLI helixturnhelix swissprot:YFES_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFES_ECOLI hmoment swissprot:YFES_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFES_ECOLI iep swissprot:YFES_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFES_ECOLI inforesidue swissprot:YFES_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFES_ECOLI octanol swissprot:YFES_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFES_ECOLI pepcoil swissprot:YFES_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFES_ECOLI pepdigest swissprot:YFES_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFES_ECOLI pepinfo swissprot:YFES_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFES_ECOLI pepnet swissprot:YFES_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFES_ECOLI pepstats swissprot:YFES_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFES_ECOLI pepwheel swissprot:YFES_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFES_ECOLI pepwindow swissprot:YFES_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFES_ECOLI sigcleave swissprot:YFES_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFES_ECOLI ## Database ID URL or Descriptions # BioGrid 4261631 135 # EcoGene EG12404 ychN # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # Gene3D 3.40.1260.10 -; 1. # InterPro IPR003787 Sulphur_relay_DrsE/F-like # InterPro IPR027396 DsrEFH-like # Organism YCHN_ECOLI Escherichia coli (strain K12) # PATRIC 32117696 VBIEscCol129921_1270 # PDB 1JX7 X-ray; 2.80 A; A/B/C/D/E/F=2-117 # PIR H64868 H64868 # Pfam PF02635 DrsE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCHN_ECOLI Protein YchN # RefSeq NP_415737 NC_000913.3 # RefSeq WP_001169669 NZ_LN832404.1 # SIMILARITY To M.jannaschii MJ0989. {ECO 0000305}. # SUBUNIT Homohexamer. The hexamer is formed by a dimer of trimers. {ECO:0000269|PubMed 12836674}. # SUPFAM SSF75169 SSF75169 # eggNOG COG1553 LUCA # eggNOG ENOG41090EX Bacteria BLAST swissprot:YCHN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCHN_ECOLI BioCyc ECOL316407:JW1210-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1210-MONOMER BioCyc EcoCyc:EG12404-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12404-MONOMER COG COG1553 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1553 DIP DIP-48042N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48042N DOI 10.1023/A:1014450817696 http://dx.doi.org/10.1023/A:1014450817696 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L28709 http://www.ebi.ac.uk/ena/data/view/L28709 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2304 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2304 EcoGene EG12404 http://www.ecogene.org/geneInfo.php?eg_id=EG12404 EnsemblBacteria AAC74303 http://www.ensemblgenomes.org/id/AAC74303 EnsemblBacteria AAC74303 http://www.ensemblgenomes.org/id/AAC74303 EnsemblBacteria BAA36087 http://www.ensemblgenomes.org/id/BAA36087 EnsemblBacteria BAA36087 http://www.ensemblgenomes.org/id/BAA36087 EnsemblBacteria BAA36087 http://www.ensemblgenomes.org/id/BAA36087 EnsemblBacteria b1219 http://www.ensemblgenomes.org/id/b1219 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 Gene3D 3.40.1260.10 http://www.cathdb.info/version/latest/superfamily/3.40.1260.10 GeneID 945794 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945794 HOGENOM HOG000229181 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000229181&db=HOGENOM6 InParanoid P0AB52 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AB52 IntAct P0AB52 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AB52* InterPro IPR003787 http://www.ebi.ac.uk/interpro/entry/IPR003787 InterPro IPR027396 http://www.ebi.ac.uk/interpro/entry/IPR027396 KEGG_Gene ecj:JW1210 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1210 KEGG_Gene eco:b1219 http://www.genome.jp/dbget-bin/www_bget?eco:b1219 KEGG_Orthology KO:K06039 http://www.genome.jp/dbget-bin/www_bget?KO:K06039 MINT MINT-1300414 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1300414 OMA TDGRGIT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TDGRGIT PDB 1JX7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1JX7 PDBsum 1JX7 http://www.ebi.ac.uk/pdbsum/1JX7 PSORT swissprot:YCHN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCHN_ECOLI PSORT-B swissprot:YCHN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCHN_ECOLI PSORT2 swissprot:YCHN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCHN_ECOLI Pfam PF02635 http://pfam.xfam.org/family/PF02635 Phobius swissprot:YCHN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCHN_ECOLI PhylomeDB P0AB52 http://phylomedb.org/?seqid=P0AB52 ProteinModelPortal P0AB52 http://www.proteinmodelportal.org/query/uniprot/P0AB52 PubMed 12836674 http://www.ncbi.nlm.nih.gov/pubmed/12836674 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415737 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415737 RefSeq WP_001169669 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001169669 SMR P0AB52 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AB52 STRING 511145.b1219 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1219&targetmode=cogs STRING COG1553 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1553&targetmode=cogs SUPFAM SSF75169 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF75169 UniProtKB YCHN_ECOLI http://www.uniprot.org/uniprot/YCHN_ECOLI UniProtKB-AC P0AB52 http://www.uniprot.org/uniprot/P0AB52 charge swissprot:YCHN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCHN_ECOLI eggNOG COG1553 http://eggnogapi.embl.de/nog_data/html/tree/COG1553 eggNOG ENOG41090EX http://eggnogapi.embl.de/nog_data/html/tree/ENOG41090EX epestfind swissprot:YCHN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCHN_ECOLI garnier swissprot:YCHN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCHN_ECOLI helixturnhelix swissprot:YCHN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCHN_ECOLI hmoment swissprot:YCHN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCHN_ECOLI iep swissprot:YCHN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCHN_ECOLI inforesidue swissprot:YCHN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCHN_ECOLI octanol swissprot:YCHN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCHN_ECOLI pepcoil swissprot:YCHN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCHN_ECOLI pepdigest swissprot:YCHN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCHN_ECOLI pepinfo swissprot:YCHN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCHN_ECOLI pepnet swissprot:YCHN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCHN_ECOLI pepstats swissprot:YCHN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCHN_ECOLI pepwheel swissprot:YCHN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCHN_ECOLI pepwindow swissprot:YCHN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCHN_ECOLI sigcleave swissprot:YCHN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCHN_ECOLI ## Database ID URL or Descriptions # AltName Xanthosine transporter {ECO 0000305} # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=136 uM for xanthosine {ECO 0000269|PubMed:7559336}; # BioGrid 4262006 18 # DISRUPTION PHENOTYPE Mutant grows very slowly on xanthosine. {ECO:0000269|PubMed 7559336}. # ENZYME REGULATION Transport is abolished by 2,4-dinitrophenol. {ECO:0000269|PubMed 7559336}. # EcoGene EG13159 xapB # FUNCTION XAPB_ECOLI Uptake of xanthosine. Driven by a proton motive force. Can also transport other nucleosides such as inosine, adenosine, cytidine, uridine and thymidine. {ECO 0000269|PubMed 7559336}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:EcoliWiki. # GO_component GO:0016021 integral component of membrane; ISS:EcoliWiki. # GO_function GO:0005337 nucleoside transmembrane transporter activity; ISA:EcoliWiki. # GO_function GO:0015553 xanthosine transmembrane transporter activity; ISS:EcoliWiki. # GO_process GO:0006810 transport; ISA:EcoliWiki. # GO_process GO:0015858 nucleoside transport; ISA:EcoliWiki. # GO_process GO:0055086 nucleobase-containing small molecule metabolic process; IMP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # InterPro IPR004740 Nuc_H_symport # InterPro IPR020846 MFS_dom # KEGG_Brite ko02000 Transporters # Organism XAPB_ECOLI Escherichia coli (strain K12) # PATRIC 32120193 VBIEscCol129921_2499 # PIR E65014 E65014 # PROSITE PS50850 MFS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Xanthosine permease {ECO:0000303|PubMed 11466294} # RefSeq NP_416901 NC_000913.3 # RefSeq WP_000020402 NZ_LN832404.1 # SIMILARITY Belongs to the major facilitator superfamily. Nucleoside:H(+) symporter (NHS) (TC 2.A.1.10) family. {ECO 0000305}. # SUBCELLULAR LOCATION XAPB_ECOLI Cell inner membrane {ECO 0000269|PubMed 11466294, ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 7559336}; Multi-pass membrane protein {ECO 0000255}. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.10 the major facilitator superfamily (mfs) # TIGRFAMs TIGR00889 2A0110 # eggNOG ENOG4105EAA Bacteria # eggNOG ENOG410ZVFU LUCA BLAST swissprot:XAPB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:XAPB_ECOLI BioCyc ECOL316407:JW2397-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2397-MONOMER BioCyc EcoCyc:XAPB-MONOMER http://biocyc.org/getid?id=EcoCyc:XAPB-MONOMER BioCyc MetaCyc:XAPB-MONOMER http://biocyc.org/getid?id=MetaCyc:XAPB-MONOMER COG COG0477 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0477 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.183.16.4900-4904.2001 http://dx.doi.org/10.1128/JB.183.16.4900-4904.2001 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X73828 http://www.ebi.ac.uk/ena/data/view/X73828 EchoBASE EB2951 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2951 EcoGene EG13159 http://www.ecogene.org/geneInfo.php?eg_id=EG13159 EnsemblBacteria AAC75459 http://www.ensemblgenomes.org/id/AAC75459 EnsemblBacteria AAC75459 http://www.ensemblgenomes.org/id/AAC75459 EnsemblBacteria BAA16274 http://www.ensemblgenomes.org/id/BAA16274 EnsemblBacteria BAA16274 http://www.ensemblgenomes.org/id/BAA16274 EnsemblBacteria BAA16274 http://www.ensemblgenomes.org/id/BAA16274 EnsemblBacteria b2406 http://www.ensemblgenomes.org/id/b2406 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005337 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005337 GO_function GO:0015553 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015553 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GO_process GO:0015858 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015858 GO_process GO:0055086 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055086 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 946868 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946868 HOGENOM HOG000026502 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000026502&db=HOGENOM6 InParanoid P45562 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45562 InterPro IPR004740 http://www.ebi.ac.uk/interpro/entry/IPR004740 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2397 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2397 KEGG_Gene eco:b2406 http://www.genome.jp/dbget-bin/www_bget?eco:b2406 KEGG_Orthology KO:K11537 http://www.genome.jp/dbget-bin/www_bget?KO:K11537 OMA WVMLINA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WVMLINA PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:XAPB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:XAPB_ECOLI PSORT-B swissprot:XAPB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:XAPB_ECOLI PSORT2 swissprot:XAPB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:XAPB_ECOLI Phobius swissprot:XAPB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:XAPB_ECOLI PhylomeDB P45562 http://phylomedb.org/?seqid=P45562 ProteinModelPortal P45562 http://www.proteinmodelportal.org/query/uniprot/P45562 PubMed 11466294 http://www.ncbi.nlm.nih.gov/pubmed/11466294 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7559336 http://www.ncbi.nlm.nih.gov/pubmed/7559336 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416901 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416901 RefSeq WP_000020402 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000020402 STRING 511145.b2406 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2406&targetmode=cogs STRING COG0477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0477&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.10 http://www.tcdb.org/search/result.php?tc=2.A.1.10 TIGRFAMs TIGR00889 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00889 UniProtKB XAPB_ECOLI http://www.uniprot.org/uniprot/XAPB_ECOLI UniProtKB-AC P45562 http://www.uniprot.org/uniprot/P45562 charge swissprot:XAPB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:XAPB_ECOLI eggNOG ENOG4105EAA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EAA eggNOG ENOG410ZVFU http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZVFU epestfind swissprot:XAPB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:XAPB_ECOLI garnier swissprot:XAPB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:XAPB_ECOLI helixturnhelix swissprot:XAPB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:XAPB_ECOLI hmoment swissprot:XAPB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:XAPB_ECOLI iep swissprot:XAPB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:XAPB_ECOLI inforesidue swissprot:XAPB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:XAPB_ECOLI octanol swissprot:XAPB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:XAPB_ECOLI pepcoil swissprot:XAPB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:XAPB_ECOLI pepdigest swissprot:XAPB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:XAPB_ECOLI pepinfo swissprot:XAPB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:XAPB_ECOLI pepnet swissprot:XAPB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:XAPB_ECOLI pepstats swissprot:XAPB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:XAPB_ECOLI pepwheel swissprot:XAPB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:XAPB_ECOLI pepwindow swissprot:XAPB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:XAPB_ECOLI sigcleave swissprot:XAPB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:XAPB_ECOLI ## Database ID URL or Descriptions # AltName AGAI_ECOLI Galactosamine-6-phosphate deaminase # BioGrid 4261594 5 # CATALYTIC ACTIVITY AGAI_ECOLI D-galactosamine 6-phosphate + H(2)O = D- tagatose 6-phosphate + NH(3). # CDD cd01399 GlcN6P_deaminase # EcoGene EG12772 agaI # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0004342 glucosamine-6-phosphate deaminase activity; IBA:GO_Central. # GO_function GO:0043877 galactosamine-6-phosphate isomerase activity; NAS:EcoliWiki. # GO_process GO:0005975 carbohydrate metabolic process; IEA:InterPro. # GO_process GO:0006046 N-acetylglucosamine catabolic process; IBA:GO_Central. # GO_process GO:0006048 UDP-N-acetylglucosamine biosynthetic process; IBA:GO_Central. # GO_process GO:0019262 N-acetylneuraminate catabolic process; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # IntAct P42912 4 # InterPro IPR004547 Glucosamine6P_isomerase # InterPro IPR006148 Glc/Gal-6P_isomerase # InterPro IPR018321 Glucosamine6P_isomerase_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00052 Galactose metabolism # MISCELLANEOUS AGAI_ECOLI In contrast to E.coli strains C and EC3132, K-12 strains cannot grow on N-acetylgalactosamine and D-galactosamine, because they carry a deletion and thus lack active PTS systems specific for these compounds. Therefore, AgaI in K-12 strains is not involved in the degradation of these compounds. # Organism AGAI_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11280 PTHR11280 # PATRIC 32121700 VBIEscCol129921_3236 # PIR A65104 A65104 # PROSITE PS01161 GLC_GALNAC_ISOMERASE # Pfam PF01182 Glucosamine_iso # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AGAI_ECOLI Putative galactosamine-6-phosphate isomerase # RefSeq NP_417610 NC_000913.3 # SIMILARITY Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. {ECO 0000305}. # eggNOG COG0363 LUCA # eggNOG ENOG4106HBN Bacteria BLAST swissprot:AGAI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AGAI_ECOLI BioCyc ECOL316407:JW3110-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3110-MONOMER BioCyc EcoCyc:G7636-MONOMER http://biocyc.org/getid?id=EcoCyc:G7636-MONOMER COG COG0363 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0363 DIP DIP-9069N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9069N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2000.01969.x http://dx.doi.org/10.1046/j.1365-2958.2000.01969.x DOI 10.1099/13500872-142-2-231 http://dx.doi.org/10.1099/13500872-142-2-231 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.3.1.- http://www.genome.jp/dbget-bin/www_bget?EC:5.3.1.- EMBL AF228498 http://www.ebi.ac.uk/ena/data/view/AF228498 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 5.3.1.- http://enzyme.expasy.org/EC/5.3.1.- EchoBASE EB2625 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2625 EcoGene EG12772 http://www.ecogene.org/geneInfo.php?eg_id=EG12772 EnsemblBacteria AAC76175 http://www.ensemblgenomes.org/id/AAC76175 EnsemblBacteria AAC76175 http://www.ensemblgenomes.org/id/AAC76175 EnsemblBacteria BAE77187 http://www.ensemblgenomes.org/id/BAE77187 EnsemblBacteria BAE77187 http://www.ensemblgenomes.org/id/BAE77187 EnsemblBacteria BAE77187 http://www.ensemblgenomes.org/id/BAE77187 EnsemblBacteria b3141 http://www.ensemblgenomes.org/id/b3141 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004342 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004342 GO_function GO:0043877 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043877 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GO_process GO:0006046 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006046 GO_process GO:0006048 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006048 GO_process GO:0019262 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019262 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 947985 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947985 HOGENOM HOG000064978 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000064978&db=HOGENOM6 InParanoid P42912 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P42912 IntAct P42912 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P42912* IntEnz 5.3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.3.1 InterPro IPR004547 http://www.ebi.ac.uk/interpro/entry/IPR004547 InterPro IPR006148 http://www.ebi.ac.uk/interpro/entry/IPR006148 InterPro IPR018321 http://www.ebi.ac.uk/interpro/entry/IPR018321 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3110 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3110 KEGG_Gene eco:b3141 http://www.genome.jp/dbget-bin/www_bget?eco:b3141 KEGG_Orthology KO:K02080 http://www.genome.jp/dbget-bin/www_bget?KO:K02080 KEGG_Pathway ko00052 http://www.genome.jp/kegg-bin/show_pathway?ko00052 KEGG_Reaction rn:R08365 http://www.genome.jp/dbget-bin/www_bget?rn:R08365 MINT MINT-1228377 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1228377 OMA ILQPACH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ILQPACH PANTHER PTHR11280 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11280 PROSITE PS01161 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01161 PSORT swissprot:AGAI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AGAI_ECOLI PSORT-B swissprot:AGAI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AGAI_ECOLI PSORT2 swissprot:AGAI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AGAI_ECOLI Pfam PF01182 http://pfam.xfam.org/family/PF01182 Phobius swissprot:AGAI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AGAI_ECOLI PhylomeDB P42912 http://phylomedb.org/?seqid=P42912 ProteinModelPortal P42912 http://www.proteinmodelportal.org/query/uniprot/P42912 PubMed 10931310 http://www.ncbi.nlm.nih.gov/pubmed/10931310 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8932697 http://www.ncbi.nlm.nih.gov/pubmed/8932697 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417610 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417610 SMR P42912 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P42912 STRING 511145.b3141 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3141&targetmode=cogs STRING COG0363 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0363&targetmode=cogs UniProtKB AGAI_ECOLI http://www.uniprot.org/uniprot/AGAI_ECOLI UniProtKB-AC P42912 http://www.uniprot.org/uniprot/P42912 charge swissprot:AGAI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AGAI_ECOLI eggNOG COG0363 http://eggnogapi.embl.de/nog_data/html/tree/COG0363 eggNOG ENOG4106HBN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106HBN epestfind swissprot:AGAI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AGAI_ECOLI garnier swissprot:AGAI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AGAI_ECOLI helixturnhelix swissprot:AGAI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AGAI_ECOLI hmoment swissprot:AGAI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AGAI_ECOLI iep swissprot:AGAI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AGAI_ECOLI inforesidue swissprot:AGAI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AGAI_ECOLI octanol swissprot:AGAI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AGAI_ECOLI pepcoil swissprot:AGAI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AGAI_ECOLI pepdigest swissprot:AGAI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AGAI_ECOLI pepinfo swissprot:AGAI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AGAI_ECOLI pepnet swissprot:AGAI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AGAI_ECOLI pepstats swissprot:AGAI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AGAI_ECOLI pepwheel swissprot:AGAI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AGAI_ECOLI pepwindow swissprot:AGAI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AGAI_ECOLI sigcleave swissprot:AGAI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AGAI_ECOLI ## Database ID URL or Descriptions # AltName NDK_ECOLI Nucleoside-2-P kinase # BRENDA 2.7.4 2026 # BioGrid 4259709 16 # CATALYTIC ACTIVITY NDK_ECOLI ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. # COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI 18420; Evidence={ECO:0000250}; # EcoGene EG10650 ndk # FUNCTION NDK_ECOLI Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004550 nucleoside diphosphate kinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006163 purine nucleotide metabolic process; IBA:GO_Central. # GO_process GO:0006183 GTP biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0006220 pyrimidine nucleotide metabolic process; IBA:GO_Central. # GO_process GO:0006228 UTP biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0006241 CTP biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0009142 nucleoside triphosphate biosynthetic process; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # HAMAP MF_00451 NDP_kinase # INTERACTION NDK_ECOLI P12295 ung; NbExp=3; IntAct=EBI-370139, EBI-559403; P0AC28 ygfA; NbExp=3; IntAct=EBI-370139, EBI-555094; # IntAct P0A763 7 # InterPro IPR001564 Nucleoside_diP_kinase # InterPro IPR023005 Nucleoside_diP_kinase_AS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00240 Pyrimidine metabolism # Organism NDK_ECOLI Escherichia coli (strain K12) # PATRIC 32120429 VBIEscCol129921_2617 # PDB 2HUR X-ray; 1.62 A; A/B/C/D/E/F=2-143 # PIR JH0495 JH0495 # PRINTS PR01243 NUCDPKINASE # PROSITE PS00469 NDP_KINASES # Pfam PF00334 NDK # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NDK_ECOLI Nucleoside diphosphate kinase # RefSeq NP_417013 NC_000913.3 # RefSeq WP_000963837 NZ_LN832404.1 # SIMILARITY Belongs to the NDK family. {ECO 0000305}. # SMART SM00562 NDK # SUBCELLULAR LOCATION NDK_ECOLI Cytoplasm. # SUBUNIT NDK_ECOLI Homotetramer. # eggNOG COG0105 LUCA # eggNOG ENOG4108UGX Bacteria BLAST swissprot:NDK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NDK_ECOLI BioCyc ECOL316407:JW2502-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2502-MONOMER BioCyc EcoCyc:NUCLEOSIDE-DIP-KIN-MONOMER http://biocyc.org/getid?id=EcoCyc:NUCLEOSIDE-DIP-KIN-MONOMER BioCyc MetaCyc:NUCLEOSIDE-DIP-KIN-MONOMER http://biocyc.org/getid?id=MetaCyc:NUCLEOSIDE-DIP-KIN-MONOMER COG COG0105 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0105 DIP DIP-31870N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31870N DOI 10.1016/0378-1119(91)90510-I http://dx.doi.org/10.1016/0378-1119(91)90510-I DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1365-2958.1995.tb02270.x http://dx.doi.org/10.1111/j.1365-2958.1995.tb02270.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.4.6 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.4.6 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X57555 http://www.ebi.ac.uk/ena/data/view/X57555 ENZYME 2.7.4.6 http://enzyme.expasy.org/EC/2.7.4.6 EchoBASE EB0644 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0644 EcoGene EG10650 http://www.ecogene.org/geneInfo.php?eg_id=EG10650 EnsemblBacteria AAC75571 http://www.ensemblgenomes.org/id/AAC75571 EnsemblBacteria AAC75571 http://www.ensemblgenomes.org/id/AAC75571 EnsemblBacteria BAA16405 http://www.ensemblgenomes.org/id/BAA16405 EnsemblBacteria BAA16405 http://www.ensemblgenomes.org/id/BAA16405 EnsemblBacteria BAA16405 http://www.ensemblgenomes.org/id/BAA16405 EnsemblBacteria b2518 http://www.ensemblgenomes.org/id/b2518 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004550 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004550 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006163 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006163 GO_process GO:0006183 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006183 GO_process GO:0006220 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006220 GO_process GO:0006228 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006228 GO_process GO:0006241 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006241 GO_process GO:0009142 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009142 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 945611 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945611 HAMAP MF_00451 http://hamap.expasy.org/unirule/MF_00451 HOGENOM HOG000224565 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000224565&db=HOGENOM6 InParanoid P0A763 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A763 IntAct P0A763 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A763* IntEnz 2.7.4.6 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.4.6 InterPro IPR001564 http://www.ebi.ac.uk/interpro/entry/IPR001564 InterPro IPR023005 http://www.ebi.ac.uk/interpro/entry/IPR023005 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2502 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2502 KEGG_Gene eco:b2518 http://www.genome.jp/dbget-bin/www_bget?eco:b2518 KEGG_Orthology KO:K00940 http://www.genome.jp/dbget-bin/www_bget?KO:K00940 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Reaction rn:R00124 http://www.genome.jp/dbget-bin/www_bget?rn:R00124 KEGG_Reaction rn:R00156 http://www.genome.jp/dbget-bin/www_bget?rn:R00156 KEGG_Reaction rn:R00330 http://www.genome.jp/dbget-bin/www_bget?rn:R00330 KEGG_Reaction rn:R00570 http://www.genome.jp/dbget-bin/www_bget?rn:R00570 KEGG_Reaction rn:R00722 http://www.genome.jp/dbget-bin/www_bget?rn:R00722 KEGG_Reaction rn:R01137 http://www.genome.jp/dbget-bin/www_bget?rn:R01137 KEGG_Reaction rn:R01857 http://www.genome.jp/dbget-bin/www_bget?rn:R01857 KEGG_Reaction rn:R02093 http://www.genome.jp/dbget-bin/www_bget?rn:R02093 KEGG_Reaction rn:R02326 http://www.genome.jp/dbget-bin/www_bget?rn:R02326 KEGG_Reaction rn:R02331 http://www.genome.jp/dbget-bin/www_bget?rn:R02331 KEGG_Reaction rn:R03530 http://www.genome.jp/dbget-bin/www_bget?rn:R03530 MINT MINT-1255778 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1255778 OMA AEHSERP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AEHSERP PDB 2HUR http://www.ebi.ac.uk/pdbe-srv/view/entry/2HUR PDBsum 2HUR http://www.ebi.ac.uk/pdbsum/2HUR PRINTS PR01243 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01243 PROSITE PS00469 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00469 PSORT swissprot:NDK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NDK_ECOLI PSORT-B swissprot:NDK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NDK_ECOLI PSORT2 swissprot:NDK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NDK_ECOLI Pfam PF00334 http://pfam.xfam.org/family/PF00334 Phobius swissprot:NDK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NDK_ECOLI PhylomeDB P0A763 http://phylomedb.org/?seqid=P0A763 ProteinModelPortal P0A763 http://www.proteinmodelportal.org/query/uniprot/P0A763 PubMed 1323446 http://www.ncbi.nlm.nih.gov/pubmed/1323446 PubMed 1657712 http://www.ncbi.nlm.nih.gov/pubmed/1657712 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7730286 http://www.ncbi.nlm.nih.gov/pubmed/7730286 PubMed 7783627 http://www.ncbi.nlm.nih.gov/pubmed/7783627 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417013 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417013 RefSeq WP_000963837 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000963837 SMART SM00562 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00562 SMR P0A763 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A763 STRING 511145.b2518 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2518&targetmode=cogs STRING COG0105 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0105&targetmode=cogs SWISS-2DPAGE P0A763 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A763 UniProtKB NDK_ECOLI http://www.uniprot.org/uniprot/NDK_ECOLI UniProtKB-AC P0A763 http://www.uniprot.org/uniprot/P0A763 charge swissprot:NDK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NDK_ECOLI eggNOG COG0105 http://eggnogapi.embl.de/nog_data/html/tree/COG0105 eggNOG ENOG4108UGX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UGX epestfind swissprot:NDK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NDK_ECOLI garnier swissprot:NDK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NDK_ECOLI helixturnhelix swissprot:NDK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NDK_ECOLI hmoment swissprot:NDK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NDK_ECOLI iep swissprot:NDK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NDK_ECOLI inforesidue swissprot:NDK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NDK_ECOLI octanol swissprot:NDK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NDK_ECOLI pepcoil swissprot:NDK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NDK_ECOLI pepdigest swissprot:NDK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NDK_ECOLI pepinfo swissprot:NDK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NDK_ECOLI pepnet swissprot:NDK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NDK_ECOLI pepstats swissprot:NDK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NDK_ECOLI pepwheel swissprot:NDK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NDK_ECOLI pepwindow swissprot:NDK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NDK_ECOLI sigcleave swissprot:NDK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NDK_ECOLI ## Database ID URL or Descriptions # AltName GSPH_ECOLI Protein transport protein HofH # AltName GSPH_ECOLI Putative general secretion pathway protein H # BioGrid 4262246 206 # EcoGene EG12887 gspH # FUNCTION GSPH_ECOLI Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. {ECO 0000305}. # GO_component GO:0015627 type II protein secretion system complex; IEA:InterPro. # GO_function GO:0008565 protein transporter activity; IEA:InterPro. # GO_process GO:0015628 protein secretion by the type II secretion system; IBA:GO_Central. # GOslim_component GO:0043234 protein complex # GOslim_function GO:0008565 protein transporter activity # GOslim_process GO:0055085 transmembrane transport # Gene3D 3.55.40.10 -; 1. # INDUCTION Silenced by the DNA-binding protein H-NS under standard growth conditions. {ECO:0000269|PubMed 11118204}. # INTERACTION GSPH_ECOLI P76086 paaX; NbExp=2; IntAct=EBI-1129978, EBI-544692; # IntAct P41443 4 # InterPro IPR002416 T2SS_protein-H # InterPro IPR012902 N_methyl_site # InterPro IPR022346 T2SS_GspH # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02044 M00331 Type II general secretion system # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko03070 Bacterial secretion system # MISCELLANEOUS GSPH_ECOLI Part of a cryptic operon that encodes proteins involved in type II secretion machinery in other organisms, but is not expressed in strain K12. # Organism GSPH_ECOLI Escherichia coli (strain K12) # PATRIC 32122090 VBIEscCol129921_3422 # PDB 2KNQ NMR; -; A=30-169 # PIR D65126 D65126 # PRINTS PR00885 BCTERIALGSPH # PROSITE PS00409 PROKAR_NTER_METHYL # Pfam PF07963 N_methyl # Pfam PF12019 GspH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GSPH_ECOLI Putative type II secretion system protein H # RefSeq NP_417788 NC_000913.3 # RefSeq WP_001076046 NZ_LN832404.1 # SIMILARITY Belongs to the GSP H family. {ECO 0000305}. # TIGRFAMs TIGR01708 typeII_sec_gspH # TIGRFAMs TIGR02532 IV_pilin_GFxxxE # eggNOG COG2165 LUCA # eggNOG ENOG41069X0 Bacteria BLAST swissprot:GSPH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GSPH_ECOLI BioCyc ECOL316407:JW3291-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3291-MONOMER BioCyc EcoCyc:G7707-MONOMER http://biocyc.org/getid?id=EcoCyc:G7707-MONOMER BioCyc MetaCyc:G7707-MONOMER http://biocyc.org/getid?id=MetaCyc:G7707-MONOMER COG COG2165 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2165 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/emboj/19.24.6697 http://dx.doi.org/10.1093/emboj/19.24.6697 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL U20786 http://www.ebi.ac.uk/ena/data/view/U20786 EchoBASE EB2724 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2724 EcoGene EG12887 http://www.ecogene.org/geneInfo.php?eg_id=EG12887 EnsemblBacteria AAC76354 http://www.ensemblgenomes.org/id/AAC76354 EnsemblBacteria AAC76354 http://www.ensemblgenomes.org/id/AAC76354 EnsemblBacteria BAE77962 http://www.ensemblgenomes.org/id/BAE77962 EnsemblBacteria BAE77962 http://www.ensemblgenomes.org/id/BAE77962 EnsemblBacteria BAE77962 http://www.ensemblgenomes.org/id/BAE77962 EnsemblBacteria b3329 http://www.ensemblgenomes.org/id/b3329 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0015627 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015627 GO_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GO_process GO:0015628 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015628 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 3.55.40.10 http://www.cathdb.info/version/latest/superfamily/3.55.40.10 GeneID 947834 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947834 HOGENOM HOG000125353 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125353&db=HOGENOM6 InParanoid P41443 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P41443 IntAct P41443 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P41443* InterPro IPR002416 http://www.ebi.ac.uk/interpro/entry/IPR002416 InterPro IPR012902 http://www.ebi.ac.uk/interpro/entry/IPR012902 InterPro IPR022346 http://www.ebi.ac.uk/interpro/entry/IPR022346 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW3291 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3291 KEGG_Gene eco:b3329 http://www.genome.jp/dbget-bin/www_bget?eco:b3329 KEGG_Orthology KO:K02457 http://www.genome.jp/dbget-bin/www_bget?KO:K02457 KEGG_Pathway ko03070 http://www.genome.jp/kegg-bin/show_pathway?ko03070 OMA GQFPEEM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GQFPEEM PDB 2KNQ http://www.ebi.ac.uk/pdbe-srv/view/entry/2KNQ PDBsum 2KNQ http://www.ebi.ac.uk/pdbsum/2KNQ PRINTS PR00885 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00885 PROSITE PS00409 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00409 PSORT swissprot:GSPH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GSPH_ECOLI PSORT-B swissprot:GSPH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GSPH_ECOLI PSORT2 swissprot:GSPH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GSPH_ECOLI Pfam PF07963 http://pfam.xfam.org/family/PF07963 Pfam PF12019 http://pfam.xfam.org/family/PF12019 Phobius swissprot:GSPH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GSPH_ECOLI ProteinModelPortal P41443 http://www.proteinmodelportal.org/query/uniprot/P41443 PubMed 11118204 http://www.ncbi.nlm.nih.gov/pubmed/11118204 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7896718 http://www.ncbi.nlm.nih.gov/pubmed/7896718 PubMed 8655552 http://www.ncbi.nlm.nih.gov/pubmed/8655552 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417788 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417788 RefSeq WP_001076046 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001076046 SMR P41443 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P41443 STRING 511145.b3329 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3329&targetmode=cogs STRING COG2165 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2165&targetmode=cogs TIGRFAMs TIGR01708 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01708 TIGRFAMs TIGR02532 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02532 UniProtKB GSPH_ECOLI http://www.uniprot.org/uniprot/GSPH_ECOLI UniProtKB-AC P41443 http://www.uniprot.org/uniprot/P41443 charge swissprot:GSPH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GSPH_ECOLI eggNOG COG2165 http://eggnogapi.embl.de/nog_data/html/tree/COG2165 eggNOG ENOG41069X0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41069X0 epestfind swissprot:GSPH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GSPH_ECOLI garnier swissprot:GSPH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GSPH_ECOLI helixturnhelix swissprot:GSPH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GSPH_ECOLI hmoment swissprot:GSPH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GSPH_ECOLI iep swissprot:GSPH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GSPH_ECOLI inforesidue swissprot:GSPH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GSPH_ECOLI octanol swissprot:GSPH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GSPH_ECOLI pepcoil swissprot:GSPH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GSPH_ECOLI pepdigest swissprot:GSPH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GSPH_ECOLI pepinfo swissprot:GSPH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GSPH_ECOLI pepnet swissprot:GSPH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GSPH_ECOLI pepstats swissprot:GSPH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GSPH_ECOLI pepwheel swissprot:GSPH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GSPH_ECOLI pepwindow swissprot:GSPH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GSPH_ECOLI sigcleave swissprot:GSPH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GSPH_ECOLI ## Database ID URL or Descriptions # BioGrid 4259766 263 # CDD cd00342 gram_neg_porins # EcoGene EG10729 phoE # FUNCTION PHOE_ECOLI Uptake of inorganic phosphate, phosphorylated compounds, and some other negatively charged solutes. # GO_component GO:0009279 cell outer membrane; IEA:UniProtKB-SubCell. # GO_component GO:0046930 pore complex; IDA:CACAO. # GO_function GO:0015288 porin activity; IEA:UniProtKB-KW. # GO_process GO:0006811 ion transport; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043234 protein complex # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # Gene3D 2.40.160.10 -; 1. # INDUCTION PHOE_ECOLI By phosphate starvation. # IntAct P02932 4 # InterPro IPR001702 Porin_Gram-ve # InterPro IPR001897 Porin_gammaproteobac # InterPro IPR013793 Porin_Gram-ve_CS # InterPro IPR023614 Porin_dom # InterPro IPR033900 Gram_neg_porin_domain # KEGG_Brite ko02000 Transporters # Organism PHOE_ECOLI Escherichia coli (strain K12) # PATRIC 32115597 VBIEscCol129921_0243 # PDB 1PHO X-ray; 3.00 A; A=22-351 # PIR A03432 MMECPE # PRINTS PR00182 ECOLNEIPORIN # PRINTS PR00183 ECOLIPORIN # PROSITE PS00576 GRAM_NEG_PORIN # Pfam PF00267 Porin_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PHOE_ECOLI Outer membrane pore protein E # RefSeq NP_414776 NC_000913.3 # RefSeq WP_000749863 NZ_LN832404.1 # SIMILARITY Belongs to the Gram-negative porin family. {ECO 0000305}. # SUBCELLULAR LOCATION PHOE_ECOLI Cell outer membrane; Multi-pass membrane protein. # SUBUNIT PHOE_ECOLI Homotrimer. # TCDB 1.B.1.1 the general bacterial porin (gbp) family # eggNOG COG3203 LUCA # eggNOG ENOG4105FCK Bacteria BLAST swissprot:PHOE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PHOE_ECOLI BioCyc ECOL316407:JW0231-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0231-MONOMER BioCyc EcoCyc:MONOMER0-282 http://biocyc.org/getid?id=EcoCyc:MONOMER0-282 COG COG3203 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3203 DIP DIP-10498N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10498N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0022-2836(83)90110-9 http://dx.doi.org/10.1016/0022-2836(83)90110-9 DOI 10.1016/0022-2836(91)90880-F http://dx.doi.org/10.1016/0022-2836(91)90880-F DOI 10.1038/350167a0 http://dx.doi.org/10.1038/350167a0 DOI 10.1038/358727a0 http://dx.doi.org/10.1038/358727a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/12.15.6337 http://dx.doi.org/10.1093/nar/12.15.6337 DOI 10.1111/j.1365-2958.1993.tb01104.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb01104.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EMBL V00316 http://www.ebi.ac.uk/ena/data/view/V00316 EMBL X00786 http://www.ebi.ac.uk/ena/data/view/X00786 EchoBASE EB0722 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0722 EcoGene EG10729 http://www.ecogene.org/geneInfo.php?eg_id=EG10729 EnsemblBacteria AAC73345 http://www.ensemblgenomes.org/id/AAC73345 EnsemblBacteria AAC73345 http://www.ensemblgenomes.org/id/AAC73345 EnsemblBacteria BAA77910 http://www.ensemblgenomes.org/id/BAA77910 EnsemblBacteria BAA77910 http://www.ensemblgenomes.org/id/BAA77910 EnsemblBacteria BAA77910 http://www.ensemblgenomes.org/id/BAA77910 EnsemblBacteria b0241 http://www.ensemblgenomes.org/id/b0241 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0046930 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046930 GO_function GO:0015288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015288 GO_process GO:0006811 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 2.40.160.10 http://www.cathdb.info/version/latest/superfamily/2.40.160.10 GeneID 944926 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944926 HOGENOM HOG000272406 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000272406&db=HOGENOM6 InParanoid P02932 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P02932 IntAct P02932 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P02932* InterPro IPR001702 http://www.ebi.ac.uk/interpro/entry/IPR001702 InterPro IPR001897 http://www.ebi.ac.uk/interpro/entry/IPR001897 InterPro IPR013793 http://www.ebi.ac.uk/interpro/entry/IPR013793 InterPro IPR023614 http://www.ebi.ac.uk/interpro/entry/IPR023614 InterPro IPR033900 http://www.ebi.ac.uk/interpro/entry/IPR033900 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0231 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0231 KEGG_Gene eco:b0241 http://www.genome.jp/dbget-bin/www_bget?eco:b0241 KEGG_Orthology KO:K11929 http://www.genome.jp/dbget-bin/www_bget?KO:K11929 MINT MINT-1285942 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1285942 OMA QWEYQYN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QWEYQYN PDB 1PHO http://www.ebi.ac.uk/pdbe-srv/view/entry/1PHO PDBsum 1PHO http://www.ebi.ac.uk/pdbsum/1PHO PRINTS PR00182 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00182 PRINTS PR00183 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00183 PROSITE PS00576 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00576 PSORT swissprot:PHOE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PHOE_ECOLI PSORT-B swissprot:PHOE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PHOE_ECOLI PSORT2 swissprot:PHOE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PHOE_ECOLI Pfam PF00267 http://pfam.xfam.org/family/PF00267 Phobius swissprot:PHOE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PHOE_ECOLI PhylomeDB P02932 http://phylomedb.org/?seqid=P02932 ProteinModelPortal P02932 http://www.proteinmodelportal.org/query/uniprot/P02932 PubMed 1380671 http://www.ncbi.nlm.nih.gov/pubmed/1380671 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1848301 http://www.ncbi.nlm.nih.gov/pubmed/1848301 PubMed 1848682 http://www.ncbi.nlm.nih.gov/pubmed/1848682 PubMed 6089111 http://www.ncbi.nlm.nih.gov/pubmed/6089111 PubMed 6341601 http://www.ncbi.nlm.nih.gov/pubmed/6341601 PubMed 7679770 http://www.ncbi.nlm.nih.gov/pubmed/7679770 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_414776 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414776 RefSeq WP_000749863 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000749863 SMR P02932 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P02932 STRING 511145.b0241 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0241&targetmode=cogs STRING COG3203 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3203&targetmode=cogs SWISS-2DPAGE P02932 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P02932 TCDB 1.B.1.1 http://www.tcdb.org/search/result.php?tc=1.B.1.1 UniProtKB PHOE_ECOLI http://www.uniprot.org/uniprot/PHOE_ECOLI UniProtKB-AC P02932 http://www.uniprot.org/uniprot/P02932 charge swissprot:PHOE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PHOE_ECOLI eggNOG COG3203 http://eggnogapi.embl.de/nog_data/html/tree/COG3203 eggNOG ENOG4105FCK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FCK epestfind swissprot:PHOE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PHOE_ECOLI garnier swissprot:PHOE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PHOE_ECOLI helixturnhelix swissprot:PHOE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PHOE_ECOLI hmoment swissprot:PHOE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PHOE_ECOLI iep swissprot:PHOE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PHOE_ECOLI inforesidue swissprot:PHOE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PHOE_ECOLI octanol swissprot:PHOE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PHOE_ECOLI pepcoil swissprot:PHOE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PHOE_ECOLI pepdigest swissprot:PHOE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PHOE_ECOLI pepinfo swissprot:PHOE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PHOE_ECOLI pepnet swissprot:PHOE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PHOE_ECOLI pepstats swissprot:PHOE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PHOE_ECOLI pepwheel swissprot:PHOE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PHOE_ECOLI pepwindow swissprot:PHOE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PHOE_ECOLI sigcleave swissprot:PHOE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PHOE_ECOLI ## Database ID URL or Descriptions # BioGrid 4260983 4 # EcoGene EG11107 ybdD # IntAct P0AAS9 8 # InterPro IPR007423 Sel_put # Organism YBDD_ECOLI Escherichia coli (strain K12) # PATRIC 32116374 VBIEscCol129921_0627 # PIR S14413 S14413 # Pfam PF04328 Sel_put # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBDD_ECOLI Uncharacterized protein YbdD # RefSeq WP_000460431 NZ_LN832404.1 # RefSeq YP_588442 NC_000913.3 # SIMILARITY To E.coli YjiX. {ECO 0000305}. # eggNOG COG2879 LUCA # eggNOG ENOG4105VCD Bacteria BLAST swissprot:YBDD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBDD_ECOLI BioCyc ECOL316407:JW0591-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0591-MONOMER BioCyc EcoCyc:MONOMER0-2660 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2660 DOI 10.1016/0022-2836(91)90879-B http://dx.doi.org/10.1016/0022-2836(91)90879-B DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EMBL X52904 http://www.ebi.ac.uk/ena/data/view/X52904 EchoBASE EB1098 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1098 EcoGene EG11107 http://www.ecogene.org/geneInfo.php?eg_id=EG11107 EnsemblBacteria ABD18642 http://www.ensemblgenomes.org/id/ABD18642 EnsemblBacteria ABD18642 http://www.ensemblgenomes.org/id/ABD18642 EnsemblBacteria BAA35228 http://www.ensemblgenomes.org/id/BAA35228 EnsemblBacteria BAA35228 http://www.ensemblgenomes.org/id/BAA35228 EnsemblBacteria BAA35228 http://www.ensemblgenomes.org/id/BAA35228 EnsemblBacteria b4512 http://www.ensemblgenomes.org/id/b4512 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 949021 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949021 HOGENOM HOG000239011 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000239011&db=HOGENOM6 InParanoid P0AAS9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAS9 IntAct P0AAS9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAS9* InterPro IPR007423 http://www.ebi.ac.uk/interpro/entry/IPR007423 KEGG_Gene ecj:JW0591 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0591 KEGG_Gene eco:b4512 http://www.genome.jp/dbget-bin/www_bget?eco:b4512 OMA MDYKTFF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MDYKTFF PSORT swissprot:YBDD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBDD_ECOLI PSORT-B swissprot:YBDD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBDD_ECOLI PSORT2 swissprot:YBDD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBDD_ECOLI Pfam PF04328 http://pfam.xfam.org/family/PF04328 Phobius swissprot:YBDD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBDD_ECOLI PhylomeDB P0AAS9 http://phylomedb.org/?seqid=P0AAS9 ProteinModelPortal P0AAS9 http://www.proteinmodelportal.org/query/uniprot/P0AAS9 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1848300 http://www.ncbi.nlm.nih.gov/pubmed/1848300 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000460431 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000460431 RefSeq YP_588442 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_588442 STRING 511145.b4512 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4512&targetmode=cogs UniProtKB YBDD_ECOLI http://www.uniprot.org/uniprot/YBDD_ECOLI UniProtKB-AC P0AAS9 http://www.uniprot.org/uniprot/P0AAS9 charge swissprot:YBDD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBDD_ECOLI eggNOG COG2879 http://eggnogapi.embl.de/nog_data/html/tree/COG2879 eggNOG ENOG4105VCD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VCD epestfind swissprot:YBDD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBDD_ECOLI garnier swissprot:YBDD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBDD_ECOLI helixturnhelix swissprot:YBDD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBDD_ECOLI hmoment swissprot:YBDD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBDD_ECOLI iep swissprot:YBDD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBDD_ECOLI inforesidue swissprot:YBDD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBDD_ECOLI octanol swissprot:YBDD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBDD_ECOLI pepcoil swissprot:YBDD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBDD_ECOLI pepdigest swissprot:YBDD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBDD_ECOLI pepinfo swissprot:YBDD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBDD_ECOLI pepnet swissprot:YBDD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBDD_ECOLI pepstats swissprot:YBDD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBDD_ECOLI pepwheel swissprot:YBDD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBDD_ECOLI pepwindow swissprot:YBDD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBDD_ECOLI sigcleave swissprot:YBDD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBDD_ECOLI ## Database ID URL or Descriptions # BioGrid 4259277 21 # EcoGene EG12792 yhbW # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # Gene3D 3.20.20.30 -; 1. # IntAct P0ADV5 3 # InterPro IPR011251 Luciferase-like_dom # InterPro IPR019949 Luciferase_OxRdatse_group-1 # Organism YHBW_ECOLI Escherichia coli (strain K12) # PATRIC 32121738 VBIEscCol129921_3255 # PIR D65106 D65106 # Pfam PF00296 Bac_luciferase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHBW_ECOLI Uncharacterized protein YhbW # RefSeq NP_417629 NC_000913.3 # RefSeq WP_000130380 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=M58338; Type=Frameshift; Positions=250; Evidence={ECO 0000305}; # SIMILARITY To bacterial alkanal monooxygenase alpha and beta chains. {ECO 0000305}. # SUPFAM SSF51679 SSF51679 # TIGRFAMs TIGR03558 oxido_grp_1 # eggNOG COG2141 LUCA # eggNOG ENOG4105DEN Bacteria BLAST swissprot:YHBW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHBW_ECOLI BioCyc ECOL316407:JW3129-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3129-MONOMER BioCyc EcoCyc:G7654-MONOMER http://biocyc.org/getid?id=EcoCyc:G7654-MONOMER DIP DIP-48197N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48197N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M58338 http://www.ebi.ac.uk/ena/data/view/M58338 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2644 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2644 EcoGene EG12792 http://www.ecogene.org/geneInfo.php?eg_id=EG12792 EnsemblBacteria AAC76194 http://www.ensemblgenomes.org/id/AAC76194 EnsemblBacteria AAC76194 http://www.ensemblgenomes.org/id/AAC76194 EnsemblBacteria BAE77206 http://www.ensemblgenomes.org/id/BAE77206 EnsemblBacteria BAE77206 http://www.ensemblgenomes.org/id/BAE77206 EnsemblBacteria BAE77206 http://www.ensemblgenomes.org/id/BAE77206 EnsemblBacteria b3160 http://www.ensemblgenomes.org/id/b3160 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0016705 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016705 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 Gene3D 3.20.20.30 http://www.cathdb.info/version/latest/superfamily/3.20.20.30 GeneID 947677 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947677 HOGENOM HOG000190694 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000190694&db=HOGENOM6 InParanoid P0ADV5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADV5 IntAct P0ADV5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADV5* InterPro IPR011251 http://www.ebi.ac.uk/interpro/entry/IPR011251 InterPro IPR019949 http://www.ebi.ac.uk/interpro/entry/IPR019949 KEGG_Gene ecj:JW3129 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3129 KEGG_Gene eco:b3160 http://www.genome.jp/dbget-bin/www_bget?eco:b3160 OMA GLWLPHE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GLWLPHE PSORT swissprot:YHBW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHBW_ECOLI PSORT-B swissprot:YHBW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHBW_ECOLI PSORT2 swissprot:YHBW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHBW_ECOLI Pfam PF00296 http://pfam.xfam.org/family/PF00296 Phobius swissprot:YHBW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHBW_ECOLI PhylomeDB P0ADV5 http://phylomedb.org/?seqid=P0ADV5 ProteinModelPortal P0ADV5 http://www.proteinmodelportal.org/query/uniprot/P0ADV5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2061290 http://www.ncbi.nlm.nih.gov/pubmed/2061290 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417629 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417629 RefSeq WP_000130380 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000130380 SMR P0ADV5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADV5 STRING 511145.b3160 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3160&targetmode=cogs SUPFAM SSF51679 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51679 TIGRFAMs TIGR03558 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03558 UniProtKB YHBW_ECOLI http://www.uniprot.org/uniprot/YHBW_ECOLI UniProtKB-AC P0ADV5 http://www.uniprot.org/uniprot/P0ADV5 charge swissprot:YHBW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHBW_ECOLI eggNOG COG2141 http://eggnogapi.embl.de/nog_data/html/tree/COG2141 eggNOG ENOG4105DEN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DEN epestfind swissprot:YHBW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHBW_ECOLI garnier swissprot:YHBW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHBW_ECOLI helixturnhelix swissprot:YHBW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHBW_ECOLI hmoment swissprot:YHBW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHBW_ECOLI iep swissprot:YHBW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHBW_ECOLI inforesidue swissprot:YHBW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHBW_ECOLI octanol swissprot:YHBW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHBW_ECOLI pepcoil swissprot:YHBW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHBW_ECOLI pepdigest swissprot:YHBW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHBW_ECOLI pepinfo swissprot:YHBW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHBW_ECOLI pepnet swissprot:YHBW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHBW_ECOLI pepstats swissprot:YHBW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHBW_ECOLI pepwheel swissprot:YHBW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHBW_ECOLI pepwindow swissprot:YHBW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHBW_ECOLI sigcleave swissprot:YHBW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHBW_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=17 uM for GTP {ECO 0000269|PubMed:19460094}; # BioGrid 4259114 9 # CATALYTIC ACTIVITY YDEH_ECOLI 2 GTP = 2 diphosphate + cyclic di-3',5'- guanylate. # CDD cd01949 GGDEF # COFACTOR YDEH_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250}; Note=Binds 1 Mg(2+) ion per monomer. {ECO 0000250}; # DISRUPTION PHENOTYPE YDEH_ECOLI A slight increase in motility. No visible effect on curli production (PubMed 18713317). Decreased biofilm formation, very little associated poly-GlcNAc production, and a complete loss of aminoglycoside-mediated induction of biofilm formation (PubMed 19460094). {ECO 0000269|PubMed 18713317, ECO 0000269|PubMed 19460094}. # ENZYME REGULATION Subject to product inhibition by c-di-GMP at a KI of 44 uM. {ECO:0000269|PubMed 19460094}. # EcoGene EG11643 ydeH # FUNCTION YDEH_ECOLI A diguanylate cyclase, overexpression leads to a strong repression of swimming; swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria. {ECO 0000269|PubMed 19460094}. # GO_function GO:0005525 GTP binding; IEA:UniProtKB-KW. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_function GO:0052621 diguanylate cyclase activity; IDA:EcoCyc. # GO_process GO:0043709 cell adhesion involved in single-species biofilm formation; IMP:EcoCyc. # GO_process GO:0051271 negative regulation of cellular component movement; IMP:EcoCyc. # GO_process GO:1902209 negative regulation of bacterial-type flagellum assembly; IMP:EcoCyc. # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0007155 cell adhesion # GOslim_process GO:0008150 biological_process # INDUCTION CsrA binds to the mRNA and reduces its levels. Expressed at low levels at both 28 and 37 degrees Celsius. Repressed by RpoS. {ECO:0000269|PubMed 19332833}. # IntAct P31129 6 # InterPro IPR000160 GGDEF_dom # InterPro IPR029787 Nucleotide_cyclase # Organism YDEH_ECOLI Escherichia coli (strain K12) # PATHWAY YDEH_ECOLI Purine metabolism; 3',5'-cyclic di-GMP biosynthesis. # PATRIC 32118370 VBIEscCol129921_1605 # PDB 3T9O X-ray; 2.20 A; A/B=2-126 # PDB 3TVK X-ray; 1.80 A; A=127-296 # PDB 4H54 X-ray; 3.90 A; A/B=2-296 # PIR B64908 B64908 # PROSITE PS50887 GGDEF # Pfam PF00990 GGDEF # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDEH_ECOLI Diguanylate cyclase YdeH # RefSeq NP_416052 NC_000913.3 # RefSeq WP_000592814 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=M96235; Type=Frameshift; Positions=176; Evidence={ECO 0000305}; # SIMILARITY Contains 1 GGDEF domain. {ECO:0000255|PROSITE- ProRule PRU00095}. # SMART SM00267 GGDEF # SUBUNIT Homodimer. {ECO:0000269|PubMed 19460094}. # SUPFAM SSF55073 SSF55073 # TIGRFAMs TIGR00254 GGDEF # eggNOG COG2199 LUCA # eggNOG ENOG4105FSR Bacteria BLAST swissprot:YDEH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDEH_ECOLI BioCyc ECOL316407:JW1528-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1528-MONOMER BioCyc EcoCyc:EG11643-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11643-MONOMER BioCyc MetaCyc:EG11643-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11643-MONOMER DIP DIP-11677N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11677N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1099/mic.0.024257-0 http://dx.doi.org/10.1099/mic.0.024257-0 DOI 10.1111/j.1365-2958.2008.06411.x http://dx.doi.org/10.1111/j.1365-2958.2008.06411.x DOI 10.1111/j.1365-2958.2009.06739.x http://dx.doi.org/10.1111/j.1365-2958.2009.06739.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.7.65 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.65 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M96235 http://www.ebi.ac.uk/ena/data/view/M96235 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.7.65 http://enzyme.expasy.org/EC/2.7.7.65 EchoBASE EB1596 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1596 EcoGene EG11643 http://www.ecogene.org/geneInfo.php?eg_id=EG11643 EnsemblBacteria AAC74608 http://www.ensemblgenomes.org/id/AAC74608 EnsemblBacteria AAC74608 http://www.ensemblgenomes.org/id/AAC74608 EnsemblBacteria BAA18882 http://www.ensemblgenomes.org/id/BAA18882 EnsemblBacteria BAA18882 http://www.ensemblgenomes.org/id/BAA18882 EnsemblBacteria BAA18882 http://www.ensemblgenomes.org/id/BAA18882 EnsemblBacteria b1535 http://www.ensemblgenomes.org/id/b1535 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0052621 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052621 GO_process GO:0043709 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043709 GO_process GO:0051271 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051271 GO_process GO:1902209 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902209 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 946075 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946075 HOGENOM HOG000120785 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120785&db=HOGENOM6 InParanoid P31129 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31129 IntAct P31129 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31129* IntEnz 2.7.7.65 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.65 InterPro IPR000160 http://www.ebi.ac.uk/interpro/entry/IPR000160 InterPro IPR029787 http://www.ebi.ac.uk/interpro/entry/IPR029787 KEGG_Gene ecj:JW1528 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1528 KEGG_Gene eco:b1535 http://www.genome.jp/dbget-bin/www_bget?eco:b1535 OMA NCTILIN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NCTILIN PDB 3T9O http://www.ebi.ac.uk/pdbe-srv/view/entry/3T9O PDB 3TVK http://www.ebi.ac.uk/pdbe-srv/view/entry/3TVK PDB 4H54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4H54 PDBsum 3T9O http://www.ebi.ac.uk/pdbsum/3T9O PDBsum 3TVK http://www.ebi.ac.uk/pdbsum/3TVK PDBsum 4H54 http://www.ebi.ac.uk/pdbsum/4H54 PROSITE PS50887 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50887 PSORT swissprot:YDEH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDEH_ECOLI PSORT-B swissprot:YDEH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDEH_ECOLI PSORT2 swissprot:YDEH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDEH_ECOLI Pfam PF00990 http://pfam.xfam.org/family/PF00990 Phobius swissprot:YDEH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDEH_ECOLI PhylomeDB P31129 http://phylomedb.org/?seqid=P31129 ProteinModelPortal P31129 http://www.proteinmodelportal.org/query/uniprot/P31129 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18713317 http://www.ncbi.nlm.nih.gov/pubmed/18713317 PubMed 19332833 http://www.ncbi.nlm.nih.gov/pubmed/19332833 PubMed 19460094 http://www.ncbi.nlm.nih.gov/pubmed/19460094 PubMed 8383113 http://www.ncbi.nlm.nih.gov/pubmed/8383113 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416052 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416052 RefSeq WP_000592814 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000592814 SMART SM00267 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00267 SMR P31129 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31129 STRING 511145.b1535 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1535&targetmode=cogs SUPFAM SSF55073 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55073 TIGRFAMs TIGR00254 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00254 UniProtKB YDEH_ECOLI http://www.uniprot.org/uniprot/YDEH_ECOLI UniProtKB-AC P31129 http://www.uniprot.org/uniprot/P31129 charge swissprot:YDEH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDEH_ECOLI eggNOG COG2199 http://eggnogapi.embl.de/nog_data/html/tree/COG2199 eggNOG ENOG4105FSR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FSR epestfind swissprot:YDEH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDEH_ECOLI garnier swissprot:YDEH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDEH_ECOLI helixturnhelix swissprot:YDEH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDEH_ECOLI hmoment swissprot:YDEH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDEH_ECOLI iep swissprot:YDEH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDEH_ECOLI inforesidue swissprot:YDEH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDEH_ECOLI octanol swissprot:YDEH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDEH_ECOLI pepcoil swissprot:YDEH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDEH_ECOLI pepdigest swissprot:YDEH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDEH_ECOLI pepinfo swissprot:YDEH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDEH_ECOLI pepnet swissprot:YDEH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDEH_ECOLI pepstats swissprot:YDEH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDEH_ECOLI pepwheel swissprot:YDEH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDEH_ECOLI pepwindow swissprot:YDEH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDEH_ECOLI sigcleave swissprot:YDEH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDEH_ECOLI ## Database ID URL or Descriptions # BioGrid 4259781 158 # EcoGene EG13551 yagL # GO_function GO:0000150 recombinase activity; IEA:InterPro. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # Gene3D 1.10.10.10 -; 1. # Gene3D 3.40.50.1390 -; 1. # IntAct P77607 3 # InterPro IPR006119 Resolv_N # InterPro IPR011517 RNA_pol_sigma70_ECF-like # InterPro IPR011991 WHTH_DNA-bd_dom # Organism YAGL_ECOLI Escherichia coli (strain K12) # PATRIC 32115679 VBIEscCol129921_0283 # PIR F64753 F64753 # Pfam PF07638 Sigma70_ECF # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAGL_ECOLI Uncharacterized protein YagL # RefSeq NP_414812 NC_000913.3 # RefSeq WP_001214248 NZ_LN832404.1 # SUPFAM SSF53041 SSF53041 # eggNOG COG1961 LUCA # eggNOG ENOG410693A Bacteria BLAST swissprot:YAGL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAGL_ECOLI BioCyc ECOL316407:JW0272-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0272-MONOMER BioCyc EcoCyc:G6149-MONOMER http://biocyc.org/getid?id=EcoCyc:G6149-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB3321 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3321 EcoGene EG13551 http://www.ecogene.org/geneInfo.php?eg_id=EG13551 EnsemblBacteria AAC73381 http://www.ensemblgenomes.org/id/AAC73381 EnsemblBacteria AAC73381 http://www.ensemblgenomes.org/id/AAC73381 EnsemblBacteria BAE76062 http://www.ensemblgenomes.org/id/BAE76062 EnsemblBacteria BAE76062 http://www.ensemblgenomes.org/id/BAE76062 EnsemblBacteria BAE76062 http://www.ensemblgenomes.org/id/BAE76062 EnsemblBacteria b0278 http://www.ensemblgenomes.org/id/b0278 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000150 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 3.40.50.1390 http://www.cathdb.info/version/latest/superfamily/3.40.50.1390 GeneID 945845 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945845 HOGENOM HOG000054877 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000054877&db=HOGENOM6 IntAct P77607 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77607* InterPro IPR006119 http://www.ebi.ac.uk/interpro/entry/IPR006119 InterPro IPR011517 http://www.ebi.ac.uk/interpro/entry/IPR011517 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW0272 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0272 KEGG_Gene eco:b0278 http://www.genome.jp/dbget-bin/www_bget?eco:b0278 PSORT swissprot:YAGL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAGL_ECOLI PSORT-B swissprot:YAGL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAGL_ECOLI PSORT2 swissprot:YAGL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAGL_ECOLI Pfam PF07638 http://pfam.xfam.org/family/PF07638 Phobius swissprot:YAGL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAGL_ECOLI ProteinModelPortal P77607 http://www.proteinmodelportal.org/query/uniprot/P77607 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414812 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414812 RefSeq WP_001214248 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001214248 SMR P77607 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77607 STRING 511145.b0278 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0278&targetmode=cogs SUPFAM SSF53041 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53041 UniProtKB YAGL_ECOLI http://www.uniprot.org/uniprot/YAGL_ECOLI UniProtKB-AC P77607 http://www.uniprot.org/uniprot/P77607 charge swissprot:YAGL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAGL_ECOLI eggNOG COG1961 http://eggnogapi.embl.de/nog_data/html/tree/COG1961 eggNOG ENOG410693A http://eggnogapi.embl.de/nog_data/html/tree/ENOG410693A epestfind swissprot:YAGL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAGL_ECOLI garnier swissprot:YAGL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAGL_ECOLI helixturnhelix swissprot:YAGL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAGL_ECOLI hmoment swissprot:YAGL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAGL_ECOLI iep swissprot:YAGL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAGL_ECOLI inforesidue swissprot:YAGL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAGL_ECOLI octanol swissprot:YAGL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAGL_ECOLI pepcoil swissprot:YAGL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAGL_ECOLI pepdigest swissprot:YAGL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAGL_ECOLI pepinfo swissprot:YAGL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAGL_ECOLI pepnet swissprot:YAGL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAGL_ECOLI pepstats swissprot:YAGL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAGL_ECOLI pepwheel swissprot:YAGL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAGL_ECOLI pepwindow swissprot:YAGL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAGL_ECOLI sigcleave swissprot:YAGL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAGL_ECOLI ## Database ID URL or Descriptions # BioGrid 4261280 11 # EcoGene EG13684 ybjO # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR019703 DUF2593 # Organism YBJO_ECOLI Escherichia coli (strain K12) # PATRIC 32116921 VBIEscCol129921_0886 # PIR B64824 B64824 # Pfam PF10767 DUF2593 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBJO_ECOLI Inner membrane protein YbjO # RefSeq NP_415379 NC_000913.3 # RefSeq WP_000389260 NZ_LN832404.1 # SUBCELLULAR LOCATION YBJO_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG ENOG4105RBQ Bacteria # eggNOG ENOG4111U50 LUCA BLAST swissprot:YBJO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBJO_ECOLI BioCyc ECOL316407:JW0842-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0842-MONOMER BioCyc EcoCyc:G6448-MONOMER http://biocyc.org/getid?id=EcoCyc:G6448-MONOMER DIP DIP-48193N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48193N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3448 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3448 EcoGene EG13684 http://www.ecogene.org/geneInfo.php?eg_id=EG13684 EnsemblBacteria AAC73945 http://www.ensemblgenomes.org/id/AAC73945 EnsemblBacteria AAC73945 http://www.ensemblgenomes.org/id/AAC73945 EnsemblBacteria BAA35569 http://www.ensemblgenomes.org/id/BAA35569 EnsemblBacteria BAA35569 http://www.ensemblgenomes.org/id/BAA35569 EnsemblBacteria BAA35569 http://www.ensemblgenomes.org/id/BAA35569 EnsemblBacteria b0858 http://www.ensemblgenomes.org/id/b0858 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 945488 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945488 HOGENOM HOG000118249 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118249&db=HOGENOM6 IntAct P0AAZ0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAZ0* InterPro IPR019703 http://www.ebi.ac.uk/interpro/entry/IPR019703 KEGG_Gene ecj:JW0842 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0842 KEGG_Gene eco:b0858 http://www.genome.jp/dbget-bin/www_bget?eco:b0858 MINT MINT-1308286 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1308286 OMA IATRCLG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IATRCLG PSORT swissprot:YBJO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBJO_ECOLI PSORT-B swissprot:YBJO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBJO_ECOLI PSORT2 swissprot:YBJO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBJO_ECOLI Pfam PF10767 http://pfam.xfam.org/family/PF10767 Phobius swissprot:YBJO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBJO_ECOLI ProteinModelPortal P0AAZ0 http://www.proteinmodelportal.org/query/uniprot/P0AAZ0 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415379 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415379 RefSeq WP_000389260 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000389260 STRING 511145.b0858 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0858&targetmode=cogs UniProtKB YBJO_ECOLI http://www.uniprot.org/uniprot/YBJO_ECOLI UniProtKB-AC P0AAZ0 http://www.uniprot.org/uniprot/P0AAZ0 charge swissprot:YBJO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBJO_ECOLI eggNOG ENOG4105RBQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105RBQ eggNOG ENOG4111U50 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111U50 epestfind swissprot:YBJO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBJO_ECOLI garnier swissprot:YBJO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBJO_ECOLI helixturnhelix swissprot:YBJO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBJO_ECOLI hmoment swissprot:YBJO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBJO_ECOLI iep swissprot:YBJO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBJO_ECOLI inforesidue swissprot:YBJO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBJO_ECOLI octanol swissprot:YBJO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBJO_ECOLI pepcoil swissprot:YBJO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBJO_ECOLI pepdigest swissprot:YBJO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBJO_ECOLI pepinfo swissprot:YBJO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBJO_ECOLI pepnet swissprot:YBJO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBJO_ECOLI pepstats swissprot:YBJO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBJO_ECOLI pepwheel swissprot:YBJO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBJO_ECOLI pepwindow swissprot:YBJO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBJO_ECOLI sigcleave swissprot:YBJO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBJO_ECOLI ## Database ID URL or Descriptions # AltName Glutamate-aspartate carrier protein {ECO 0000305} # AltName Proton-glutamate-aspartate transport protein {ECO:0000303|PubMed 1551855} # BIOPHYSICOCHEMICAL PROPERTIES GLTP_ECOLI Kinetic parameters Vmax=2.6 nmol/min/mg enzyme with glutamate as substrate {ECO 0000269|PubMed 2537813}; Vmax=2.3 nmol/min/mg enzyme with aspartate as substrate {ECO 0000269|PubMed 2537813}; # BioGrid 4262679 6 # ENZYME REGULATION GLTP_ECOLI Glutamate uptake is inhibited by L-cysteate and beta-hydroxyaspartate. Inhibited by the uncoupler carbonylcyanide m-chlorophenylhydrazone (CCCP). {ECO 0000269|PubMed 1971622, ECO 0000269|PubMed 2537813, ECO 0000269|PubMed 336628}. # EcoGene EG10405 gltP # FUNCTION GLTP_ECOLI Catalyzes the proton-dependent, binding-protein- independent transport of glutamate and aspartate. {ECO 0000269|PubMed 1971622, ECO 0000269|PubMed 2537813, ECO 0000269|PubMed 336628, ECO 0000269|PubMed 8596452}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015293 symporter activity; IEA:UniProtKB-KW. # GO_process GO:0006835 dicarboxylic acid transport; IMP:EcoCyc. # GO_process GO:0015810 aspartate transport; IEA:InterPro. # GO_process GO:0015813 L-glutamate transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # Gene3D 1.10.3860.10 -; 1. # HAMAP MF_02063 GltP_subfam # InterPro IPR001991 Na-dicarboxylate_symporter # InterPro IPR018107 Na-dicarboxylate_symporter_CS # InterPro IPR033380 GltP/GltT # Organism GLTP_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11958 PTHR11958 # PANTHER PTHR11958:SF26 PTHR11958:SF26 # PATRIC 32123705 VBIEscCol129921_4201 # PIR A42384 A42384 # PRINTS PR00173 EDTRNSPORT # PROSITE PS00713 NA_DICARBOXYL_SYMP_1 # PROSITE PS00714 NA_DICARBOXYL_SYMP_2 # Pfam PF00375 SDF # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Proton/glutamate-aspartate symporter {ECO:0000255|HAMAP-Rule MF_02063, ECO:0000305} # RefSeq NP_418501 NC_000913.3 # RefSeq WP_000789592 NZ_LN832404.1 # SIMILARITY GLTP_ECOLI Belongs to the dicarboxylate/amino acid cation symporter (DAACS) (TC 2.A.23) family. GltP subfamily. {ECO 0000255|HAMAP-Rule MF_02063, ECO 0000305}. # SUBCELLULAR LOCATION GLTP_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_02063, ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 1971622, ECO 0000269|PubMed 2537813}; Multi- pass membrane protein {ECO 0000255|HAMAP-Rule MF_02063}. # SUPFAM SSF118215 SSF118215 # TCDB 2.A.23.1:the dicarboxylate/amino acid cation (na(+) or h(+)) symporter (daacs) family # eggNOG COG1301 LUCA # eggNOG ENOG4105CK2 Bacteria BLAST swissprot:GLTP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLTP_ECOLI BioCyc ECOL316407:JW4038-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4038-MONOMER BioCyc EcoCyc:GLTP-MONOMER http://biocyc.org/getid?id=EcoCyc:GLTP-MONOMER BioCyc MetaCyc:GLTP-MONOMER http://biocyc.org/getid?id=MetaCyc:GLTP-MONOMER COG COG1301 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1301 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1111/j.1365-2958.1995.mmi_18010123.x http://dx.doi.org/10.1111/j.1365-2958.1995.mmi_18010123.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M32488 http://www.ebi.ac.uk/ena/data/view/M32488 EMBL M84805 http://www.ebi.ac.uk/ena/data/view/M84805 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0400 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0400 EcoGene EG10405 http://www.ecogene.org/geneInfo.php?eg_id=EG10405 EnsemblBacteria AAD13460 http://www.ensemblgenomes.org/id/AAD13460 EnsemblBacteria AAD13460 http://www.ensemblgenomes.org/id/AAD13460 EnsemblBacteria BAE78079 http://www.ensemblgenomes.org/id/BAE78079 EnsemblBacteria BAE78079 http://www.ensemblgenomes.org/id/BAE78079 EnsemblBacteria BAE78079 http://www.ensemblgenomes.org/id/BAE78079 EnsemblBacteria b4077 http://www.ensemblgenomes.org/id/b4077 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015293 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293 GO_process GO:0006835 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006835 GO_process GO:0015810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015810 GO_process GO:0015813 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015813 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 1.10.3860.10 http://www.cathdb.info/version/latest/superfamily/1.10.3860.10 GeneID 948591 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948591 HAMAP MF_02063 http://hamap.expasy.org/unirule/MF_02063 HOGENOM HOG000208778 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000208778&db=HOGENOM6 InParanoid P21345 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P21345 InterPro IPR001991 http://www.ebi.ac.uk/interpro/entry/IPR001991 InterPro IPR018107 http://www.ebi.ac.uk/interpro/entry/IPR018107 InterPro IPR033380 http://www.ebi.ac.uk/interpro/entry/IPR033380 KEGG_Gene ecj:JW4038 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4038 KEGG_Gene eco:b4077 http://www.genome.jp/dbget-bin/www_bget?eco:b4077 KEGG_Orthology KO:K11102 http://www.genome.jp/dbget-bin/www_bget?KO:K11102 OMA ICSFVVP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ICSFVVP PANTHER PTHR11958 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11958 PANTHER PTHR11958:SF26 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11958:SF26 PRINTS PR00173 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00173 PROSITE PS00713 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00713 PROSITE PS00714 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00714 PSORT swissprot:GLTP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLTP_ECOLI PSORT-B swissprot:GLTP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLTP_ECOLI PSORT2 swissprot:GLTP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLTP_ECOLI Pfam PF00375 http://pfam.xfam.org/family/PF00375 Phobius swissprot:GLTP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLTP_ECOLI PhylomeDB P21345 http://phylomedb.org/?seqid=P21345 ProteinModelPortal P21345 http://www.proteinmodelportal.org/query/uniprot/P21345 PubMed 1551855 http://www.ncbi.nlm.nih.gov/pubmed/1551855 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1971622 http://www.ncbi.nlm.nih.gov/pubmed/1971622 PubMed 2537813 http://www.ncbi.nlm.nih.gov/pubmed/2537813 PubMed 336628 http://www.ncbi.nlm.nih.gov/pubmed/336628 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 8596452 http://www.ncbi.nlm.nih.gov/pubmed/8596452 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418501 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418501 RefSeq WP_000789592 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000789592 STRING 511145.b4077 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4077&targetmode=cogs STRING COG1301 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1301&targetmode=cogs SUPFAM SSF118215 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF118215 TCDB 2.A.23.1 http://www.tcdb.org/search/result.php?tc=2.A.23.1 UniProtKB GLTP_ECOLI http://www.uniprot.org/uniprot/GLTP_ECOLI UniProtKB-AC P21345 http://www.uniprot.org/uniprot/P21345 charge swissprot:GLTP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLTP_ECOLI eggNOG COG1301 http://eggnogapi.embl.de/nog_data/html/tree/COG1301 eggNOG ENOG4105CK2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CK2 epestfind swissprot:GLTP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLTP_ECOLI garnier swissprot:GLTP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLTP_ECOLI helixturnhelix swissprot:GLTP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLTP_ECOLI hmoment swissprot:GLTP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLTP_ECOLI iep swissprot:GLTP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLTP_ECOLI inforesidue swissprot:GLTP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLTP_ECOLI octanol swissprot:GLTP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLTP_ECOLI pepcoil swissprot:GLTP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLTP_ECOLI pepdigest swissprot:GLTP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLTP_ECOLI pepinfo swissprot:GLTP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLTP_ECOLI pepnet swissprot:GLTP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLTP_ECOLI pepstats swissprot:GLTP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLTP_ECOLI pepwheel swissprot:GLTP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLTP_ECOLI pepwindow swissprot:GLTP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLTP_ECOLI sigcleave swissprot:GLTP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLTP_ECOLI ## Database ID URL or Descriptions # AltName GSPK_ECOLI Putative general secretion pathway protein K # BioGrid 4263432 343 # EcoGene EG12894 gspK # FUNCTION GSPK_ECOLI Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. {ECO 0000305}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0009306 protein secretion; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006810 transport # INDUCTION Silenced by the DNA-binding protein H-NS under standard growth conditions. {ECO:0000269|PubMed 11118204}. # InterPro IPR005628 GspK # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02044 M00331 Type II general secretion system # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko03070 Bacterial secretion system # MISCELLANEOUS GSPK_ECOLI Part of a cryptic operon that encodes proteins involved in type II secretion machinery in other organisms, but is not expressed in strain K12. # Organism GSPK_ECOLI Escherichia coli (strain K12) # PATRIC 32122096 VBIEscCol129921_3425 # PIR G65126 G65126 # PIRSF PIRSF002786 XcpX # Pfam PF03934 T2SSK # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GSPK_ECOLI Putative type II secretion system protein K # RefSeq NP_417791 NC_000913.3 # RefSeq WP_001058522 NZ_LN832404.1 # SIMILARITY Belongs to the GSP K family. {ECO 0000305}. # SUBCELLULAR LOCATION GSPK_ECOLI Cell inner membrane {ECO 0000305}; Single- pass membrane protein {ECO 0000305}. # eggNOG COG3156 LUCA # eggNOG ENOG4105R04 Bacteria BLAST swissprot:GSPK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GSPK_ECOLI BioCyc ECOL316407:JW3294-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3294-MONOMER BioCyc EcoCyc:G7710-MONOMER http://biocyc.org/getid?id=EcoCyc:G7710-MONOMER BioCyc MetaCyc:G7710-MONOMER http://biocyc.org/getid?id=MetaCyc:G7710-MONOMER COG COG3156 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3156 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/emboj/19.24.6697 http://dx.doi.org/10.1093/emboj/19.24.6697 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2731 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2731 EcoGene EG12894 http://www.ecogene.org/geneInfo.php?eg_id=EG12894 EnsemblBacteria AAC76357 http://www.ensemblgenomes.org/id/AAC76357 EnsemblBacteria AAC76357 http://www.ensemblgenomes.org/id/AAC76357 EnsemblBacteria BAE77959 http://www.ensemblgenomes.org/id/BAE77959 EnsemblBacteria BAE77959 http://www.ensemblgenomes.org/id/BAE77959 EnsemblBacteria BAE77959 http://www.ensemblgenomes.org/id/BAE77959 EnsemblBacteria b3332 http://www.ensemblgenomes.org/id/b3332 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0009306 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009306 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 947831 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947831 HOGENOM HOG000009791 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009791&db=HOGENOM6 InParanoid P45762 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45762 InterPro IPR005628 http://www.ebi.ac.uk/interpro/entry/IPR005628 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW3294 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3294 KEGG_Gene eco:b3332 http://www.genome.jp/dbget-bin/www_bget?eco:b3332 KEGG_Orthology KO:K02460 http://www.genome.jp/dbget-bin/www_bget?KO:K02460 KEGG_Pathway ko03070 http://www.genome.jp/kegg-bin/show_pathway?ko03070 OMA WFFADIQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WFFADIQ PSORT swissprot:GSPK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GSPK_ECOLI PSORT-B swissprot:GSPK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GSPK_ECOLI PSORT2 swissprot:GSPK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GSPK_ECOLI Pfam PF03934 http://pfam.xfam.org/family/PF03934 Phobius swissprot:GSPK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GSPK_ECOLI ProteinModelPortal P45762 http://www.proteinmodelportal.org/query/uniprot/P45762 PubMed 11118204 http://www.ncbi.nlm.nih.gov/pubmed/11118204 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8655552 http://www.ncbi.nlm.nih.gov/pubmed/8655552 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417791 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417791 RefSeq WP_001058522 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001058522 SMR P45762 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45762 STRING 511145.b3332 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3332&targetmode=cogs STRING COG3156 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3156&targetmode=cogs UniProtKB GSPK_ECOLI http://www.uniprot.org/uniprot/GSPK_ECOLI UniProtKB-AC P45762 http://www.uniprot.org/uniprot/P45762 charge swissprot:GSPK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GSPK_ECOLI eggNOG COG3156 http://eggnogapi.embl.de/nog_data/html/tree/COG3156 eggNOG ENOG4105R04 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105R04 epestfind swissprot:GSPK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GSPK_ECOLI garnier swissprot:GSPK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GSPK_ECOLI helixturnhelix swissprot:GSPK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GSPK_ECOLI hmoment swissprot:GSPK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GSPK_ECOLI iep swissprot:GSPK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GSPK_ECOLI inforesidue swissprot:GSPK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GSPK_ECOLI octanol swissprot:GSPK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GSPK_ECOLI pepcoil swissprot:GSPK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GSPK_ECOLI pepdigest swissprot:GSPK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GSPK_ECOLI pepinfo swissprot:GSPK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GSPK_ECOLI pepnet swissprot:GSPK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GSPK_ECOLI pepstats swissprot:GSPK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GSPK_ECOLI pepwheel swissprot:GSPK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GSPK_ECOLI pepwindow swissprot:GSPK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GSPK_ECOLI sigcleave swissprot:GSPK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GSPK_ECOLI ## Database ID URL or Descriptions # BioGrid 4262564 171 # EcoGene EG11193 dinD # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0009432 SOS response; IMP:EcoCyc. # GOslim_process GO:0006950 response to stress # IntAct P23840 8 # MISCELLANEOUS DIND_ECOLI Essential for E.coli under special growth condition. # Organism DIND_ECOLI Escherichia coli (strain K12) # PATRIC 32122777 VBIEscCol129921_3765 # PIR G65165 G65165 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DIND_ECOLI DNA-damage-inducible protein D # RefSeq NP_418102 NC_000913.3 # RefSeq WP_001350563 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA61998.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # eggNOG ENOG4105F5P Bacteria # eggNOG ENOG410XQQP LUCA BLAST swissprot:DIND_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DIND_ECOLI BioCyc ECOL316407:JW3620-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3620-MONOMER BioCyc EcoCyc:EG11193-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11193-MONOMER DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1006/jmbi.1994.1528 http://dx.doi.org/10.1006/jmbi.1994.1528 DOI 10.1016/0923-2508(91)90042-9 http://dx.doi.org/10.1016/0923-2508(91)90042-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1989.tb00184.x http://dx.doi.org/10.1111/j.1365-2958.1989.tb00184.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M31529 http://www.ebi.ac.uk/ena/data/view/M31529 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X14235 http://www.ebi.ac.uk/ena/data/view/X14235 EchoBASE EB1179 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1179 EcoGene EG11193 http://www.ecogene.org/geneInfo.php?eg_id=EG11193 EnsemblBacteria AAC76669 http://www.ensemblgenomes.org/id/AAC76669 EnsemblBacteria AAC76669 http://www.ensemblgenomes.org/id/AAC76669 EnsemblBacteria BAE77648 http://www.ensemblgenomes.org/id/BAE77648 EnsemblBacteria BAE77648 http://www.ensemblgenomes.org/id/BAE77648 EnsemblBacteria BAE77648 http://www.ensemblgenomes.org/id/BAE77648 EnsemblBacteria b3645 http://www.ensemblgenomes.org/id/b3645 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0009432 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009432 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 948153 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948153 HOGENOM HOG000003507 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000003507&db=HOGENOM6 InParanoid P23840 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23840 IntAct P23840 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P23840* KEGG_Gene ecj:JW3620 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3620 KEGG_Gene eco:b3645 http://www.genome.jp/dbget-bin/www_bget?eco:b3645 KEGG_Orthology KO:K14623 http://www.genome.jp/dbget-bin/www_bget?KO:K14623 OMA RIRSKGD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RIRSKGD PSORT swissprot:DIND_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DIND_ECOLI PSORT-B swissprot:DIND_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DIND_ECOLI PSORT2 swissprot:DIND_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DIND_ECOLI Phobius swissprot:DIND_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DIND_ECOLI ProteinModelPortal P23840 http://www.proteinmodelportal.org/query/uniprot/P23840 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1925027 http://www.ncbi.nlm.nih.gov/pubmed/1925027 PubMed 2158980 http://www.ncbi.nlm.nih.gov/pubmed/2158980 PubMed 2664418 http://www.ncbi.nlm.nih.gov/pubmed/2664418 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 8002613 http://www.ncbi.nlm.nih.gov/pubmed/8002613 PubMed 8057377 http://www.ncbi.nlm.nih.gov/pubmed/8057377 PubMed 8195095 http://www.ncbi.nlm.nih.gov/pubmed/8195095 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418102 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418102 RefSeq WP_001350563 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001350563 STRING 511145.b3645 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3645&targetmode=cogs UniProtKB DIND_ECOLI http://www.uniprot.org/uniprot/DIND_ECOLI UniProtKB-AC P23840 http://www.uniprot.org/uniprot/P23840 charge swissprot:DIND_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DIND_ECOLI eggNOG ENOG4105F5P http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F5P eggNOG ENOG410XQQP http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQQP epestfind swissprot:DIND_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DIND_ECOLI garnier swissprot:DIND_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DIND_ECOLI helixturnhelix swissprot:DIND_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DIND_ECOLI hmoment swissprot:DIND_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DIND_ECOLI iep swissprot:DIND_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DIND_ECOLI inforesidue swissprot:DIND_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DIND_ECOLI octanol swissprot:DIND_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DIND_ECOLI pepcoil swissprot:DIND_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DIND_ECOLI pepdigest swissprot:DIND_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DIND_ECOLI pepinfo swissprot:DIND_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DIND_ECOLI pepnet swissprot:DIND_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DIND_ECOLI pepstats swissprot:DIND_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DIND_ECOLI pepwheel swissprot:DIND_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DIND_ECOLI pepwindow swissprot:DIND_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DIND_ECOLI sigcleave swissprot:DIND_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DIND_ECOLI ## Database ID URL or Descriptions # AltName END8_ECOLI DNA glycosylase/AP lyase Nei # AltName END8_ECOLI DNA-(apurinic or apyrimidinic site) lyase Nei # AltName END8_ECOLI Endonuclease VIII # BRENDA 3.2.2.23 2026 # BRENDA 4.2.99.18 2026 # BioGrid 4259928 110 # CATALYTIC ACTIVITY END8_ECOLI Removes damaged bases from DNA, leaving an abasic site. # CATALYTIC ACTIVITY END8_ECOLI The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. # COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI 29105; Note=Binds 1 zinc ion per subunit.; # EcoGene EG13237 nei # FUNCTION END8_ECOLI Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Acts on DNA bubble and 3'-fork structures, suggesting a role in replication-associated DNA repair. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. {ECO 0000269|PubMed 20031487}. # GO_function GO:0000703 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0003684 damaged DNA binding; IDA:EcoliWiki. # GO_function GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity; IDA:EcoliWiki. # GO_function GO:0008270 zinc ion binding; IDA:EcoliWiki. # GO_process GO:0006284 base-excision repair; IDA:EcoliWiki. # GO_process GO:0006289 nucleotide-excision repair; IEA:InterPro. # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004518 nuclease activity # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # HAMAP MF_01253 Endonuclease_8 # IntAct P50465 13 # InterPro IPR000214 Znf_DNA_glyclase/AP_lyase # InterPro IPR010663 Znf_FPG/IleRS # InterPro IPR010979 Ribosomal_S13-like_H2TH # InterPro IPR012319 FPG_cat # InterPro IPR015886 DNA_glyclase/AP_lyase_DNA-bd # InterPro IPR015887 DNA_glyclase_Znf_dom_DNA_BS # InterPro IPR023713 Endonuclease-VIII # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko03410 Base excision repair # Organism END8_ECOLI Escherichia coli (strain K12) # PANTHER PTHR22993:SF14 PTHR22993:SF14 # PATRIC 32116623 VBIEscCol129921_0744 # PDB 1K3W X-ray; 1.42 A; A=2-263 # PDB 1K3X X-ray; 1.25 A; A=2-263 # PDB 1Q39 X-ray; 2.80 A; A=2-263 # PDB 1Q3B X-ray; 2.05 A; A=2-263 # PDB 1Q3C X-ray; 2.30 A; A=2-263 # PDB 2EA0 X-ray; 1.40 A; A=2-263 # PDB 2OPF X-ray; 1.85 A; A=2-263 # PDB 2OQ4 X-ray; 2.60 A; A/B=2-263 # PIR A64807 A64807 # PROSITE PS01242 ZF_FPG_1 # PROSITE PS51066 ZF_FPG_2 # PROSITE PS51068 FPG_CAT # Pfam PF01149 Fapy_DNA_glyco # Pfam PF06827 zf-FPG_IleRS # Pfam PF06831 H2TH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName END8_ECOLI Endonuclease 8 # RefSeq NP_415242 NC_000913.3 # RefSeq WP_001113989 NZ_LN832404.1 # SIMILARITY Belongs to the FPG family. {ECO 0000305}. # SIMILARITY Contains 1 FPG-type zinc finger. {ECO 0000305}. # SMART SM00898 Fapy_DNA_glyco # SMART SM01232 H2TH # SUPFAM SSF46946 SSF46946 # SUPFAM SSF81624 SSF81624 # eggNOG COG0266 LUCA # eggNOG ENOG4108S0J Bacteria BLAST swissprot:END8_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:END8_ECOLI BioCyc ECOL316407:JW0704-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0704-MONOMER BioCyc EcoCyc:G6383-MONOMER http://biocyc.org/getid?id=EcoCyc:G6383-MONOMER COG COG0266 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0266 DIP DIP-10327N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10327N DOI 10.1016/j.dnarep.2009.11.008 http://dx.doi.org/10.1016/j.dnarep.2009.11.008 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M110499200 http://dx.doi.org/10.1074/jbc.M110499200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/emboj/21.4.789 http://dx.doi.org/10.1093/emboj/21.4.789 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DisProt DP00375 http://www.disprot.org/protein.php?id=DP00375 EC_number EC:3.2.2.- http://www.genome.jp/dbget-bin/www_bget?EC:3.2.2.- EC_number EC:4.2.99.18 http://www.genome.jp/dbget-bin/www_bget?EC:4.2.99.18 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D89754 http://www.ebi.ac.uk/ena/data/view/D89754 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U38616 http://www.ebi.ac.uk/ena/data/view/U38616 ENZYME 3.2.2.- http://enzyme.expasy.org/EC/3.2.2.- ENZYME 4.2.99.18 http://enzyme.expasy.org/EC/4.2.99.18 EchoBASE EB3026 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3026 EcoGene EG13237 http://www.ecogene.org/geneInfo.php?eg_id=EG13237 EnsemblBacteria AAC73808 http://www.ensemblgenomes.org/id/AAC73808 EnsemblBacteria AAC73808 http://www.ensemblgenomes.org/id/AAC73808 EnsemblBacteria BAA35378 http://www.ensemblgenomes.org/id/BAA35378 EnsemblBacteria BAA35378 http://www.ensemblgenomes.org/id/BAA35378 EnsemblBacteria BAA35378 http://www.ensemblgenomes.org/id/BAA35378 EnsemblBacteria b0714 http://www.ensemblgenomes.org/id/b0714 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000703 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000703 GO_function GO:0003684 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003684 GO_function GO:0003906 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003906 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_process GO:0006284 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006284 GO_process GO:0006289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006289 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 945320 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945320 HAMAP MF_01253 http://hamap.expasy.org/unirule/MF_01253 HOGENOM HOG000020882 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000020882&db=HOGENOM6 InParanoid P50465 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P50465 IntAct P50465 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P50465* IntEnz 3.2.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.2.2 IntEnz 4.2.99.18 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.99.18 InterPro IPR000214 http://www.ebi.ac.uk/interpro/entry/IPR000214 InterPro IPR010663 http://www.ebi.ac.uk/interpro/entry/IPR010663 InterPro IPR010979 http://www.ebi.ac.uk/interpro/entry/IPR010979 InterPro IPR012319 http://www.ebi.ac.uk/interpro/entry/IPR012319 InterPro IPR015886 http://www.ebi.ac.uk/interpro/entry/IPR015886 InterPro IPR015887 http://www.ebi.ac.uk/interpro/entry/IPR015887 InterPro IPR023713 http://www.ebi.ac.uk/interpro/entry/IPR023713 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW0704 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0704 KEGG_Gene eco:b0714 http://www.genome.jp/dbget-bin/www_bget?eco:b0714 KEGG_Orthology KO:K05522 http://www.genome.jp/dbget-bin/www_bget?KO:K05522 KEGG_Pathway ko03410 http://www.genome.jp/kegg-bin/show_pathway?ko03410 MINT MINT-1221359 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1221359 OMA QRIGPDV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QRIGPDV PANTHER PTHR22993:SF14 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22993:SF14 PDB 1K3W http://www.ebi.ac.uk/pdbe-srv/view/entry/1K3W PDB 1K3X http://www.ebi.ac.uk/pdbe-srv/view/entry/1K3X PDB 1Q39 http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q39 PDB 1Q3B http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q3B PDB 1Q3C http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q3C PDB 2EA0 http://www.ebi.ac.uk/pdbe-srv/view/entry/2EA0 PDB 2OPF http://www.ebi.ac.uk/pdbe-srv/view/entry/2OPF PDB 2OQ4 http://www.ebi.ac.uk/pdbe-srv/view/entry/2OQ4 PDBsum 1K3W http://www.ebi.ac.uk/pdbsum/1K3W PDBsum 1K3X http://www.ebi.ac.uk/pdbsum/1K3X PDBsum 1Q39 http://www.ebi.ac.uk/pdbsum/1Q39 PDBsum 1Q3B http://www.ebi.ac.uk/pdbsum/1Q3B PDBsum 1Q3C http://www.ebi.ac.uk/pdbsum/1Q3C PDBsum 2EA0 http://www.ebi.ac.uk/pdbsum/2EA0 PDBsum 2OPF http://www.ebi.ac.uk/pdbsum/2OPF PDBsum 2OQ4 http://www.ebi.ac.uk/pdbsum/2OQ4 PROSITE PS01242 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01242 PROSITE PS51066 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51066 PROSITE PS51068 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51068 PSORT swissprot:END8_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:END8_ECOLI PSORT-B swissprot:END8_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:END8_ECOLI PSORT2 swissprot:END8_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:END8_ECOLI Pfam PF01149 http://pfam.xfam.org/family/PF01149 Pfam PF06827 http://pfam.xfam.org/family/PF06827 Pfam PF06831 http://pfam.xfam.org/family/PF06831 Phobius swissprot:END8_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:END8_ECOLI PhylomeDB P50465 http://phylomedb.org/?seqid=P50465 ProteinModelPortal P50465 http://www.proteinmodelportal.org/query/uniprot/P50465 PubMed 11711552 http://www.ncbi.nlm.nih.gov/pubmed/11711552 PubMed 11847126 http://www.ncbi.nlm.nih.gov/pubmed/11847126 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20031487 http://www.ncbi.nlm.nih.gov/pubmed/20031487 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9171429 http://www.ncbi.nlm.nih.gov/pubmed/9171429 PubMed 9171430 http://www.ncbi.nlm.nih.gov/pubmed/9171430 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415242 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415242 RefSeq WP_001113989 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001113989 SMART SM00898 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00898 SMART SM01232 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01232 SMR P50465 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P50465 STRING 511145.b0714 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0714&targetmode=cogs STRING COG0266 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0266&targetmode=cogs SUPFAM SSF46946 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46946 SUPFAM SSF81624 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81624 UniProtKB END8_ECOLI http://www.uniprot.org/uniprot/END8_ECOLI UniProtKB-AC P50465 http://www.uniprot.org/uniprot/P50465 charge swissprot:END8_ECOLI http://rest.g-language.org/emboss/charge/swissprot:END8_ECOLI eggNOG COG0266 http://eggnogapi.embl.de/nog_data/html/tree/COG0266 eggNOG ENOG4108S0J http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108S0J epestfind swissprot:END8_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:END8_ECOLI garnier swissprot:END8_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:END8_ECOLI helixturnhelix swissprot:END8_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:END8_ECOLI hmoment swissprot:END8_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:END8_ECOLI iep swissprot:END8_ECOLI http://rest.g-language.org/emboss/iep/swissprot:END8_ECOLI inforesidue swissprot:END8_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:END8_ECOLI octanol swissprot:END8_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:END8_ECOLI pepcoil swissprot:END8_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:END8_ECOLI pepdigest swissprot:END8_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:END8_ECOLI pepinfo swissprot:END8_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:END8_ECOLI pepnet swissprot:END8_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:END8_ECOLI pepstats swissprot:END8_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:END8_ECOLI pepwheel swissprot:END8_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:END8_ECOLI pepwindow swissprot:END8_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:END8_ECOLI sigcleave swissprot:END8_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:END8_ECOLI ## Database ID URL or Descriptions # AltName MALY_ECOLI Beta-cystathionase # AltName MALY_ECOLI Cysteine lyase # AltName MALY_ECOLI Cysteine lyase # BioGrid 4261731 9 # CATALYTIC ACTIVITY L-cystathionine + H(2)O = L-homocysteine + NH(3) + pyruvate. {ECO:0000269|PubMed 7665481}. # COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI 597326; # EcoGene EG10564 malY # FUNCTION MALY_ECOLI Acts as a beta-cystathionase and as a repressor of the maltose regulon. # GO_function GO:0004121 cystathionine beta-lyase activity; IDA:EcoCyc. # GO_function GO:0030170 pyridoxal phosphate binding; IDA:EcoCyc. # GO_function GO:0080146 L-cysteine desulfhydrase activity; IMP:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0009086 methionine biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity; IDA:EcoCyc. # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.640.10 -; 1. # Gene3D 3.90.1150.10 -; 1. # IntAct P23256 10 # InterPro IPR004839 Aminotransferase_I/II # InterPro IPR015421 PyrdxlP-dep_Trfase_major_sub1 # InterPro IPR015422 PyrdxlP-dep_Trfase_major_sub2 # InterPro IPR015424 PyrdxlP-dep_Trfase # InterPro IPR027619 C_S_lyase_PatB # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01007 Amino acid related enzymes # KEGG_Pathway ko00270 Cysteine and methionine metabolism # KEGG_Pathway ko00450 Selenocompound metabolism # KEGG_Pathway ko00920 Sulfur metabolism # Organism MALY_ECOLI Escherichia coli (strain K12) # PATRIC 32118546 VBIEscCol129921_1693 # PDB 1D2F X-ray; 2.50 A; A/B=1-390 # PIR C42477 C42477 # Pfam PF00155 Aminotran_1_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MALY_ECOLI Cystathionine beta-lyase MalY # RecName MALY_ECOLI Maltose regulon modulator # RecName MALY_ECOLI Protein MalY # RecName MALY_ECOLI Protein MalY # RefSeq NP_416139 NC_000913.3 # RefSeq WP_000459379 NZ_LN832404.1 # SIMILARITY Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily. {ECO 0000305}. # SUBUNIT Homodimer. Interacts with MalT. {ECO:0000269|PubMed 10698925}. # SUPFAM SSF53383 SSF53383 # TIGRFAMs TIGR04350 C_S_lyase_PatB # eggNOG COG1168 LUCA # eggNOG ENOG4105C87 Bacteria BLAST swissprot:MALY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MALY_ECOLI BioCyc ECOL316407:JW1614-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1614-MONOMER BioCyc EcoCyc:EG10564-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10564-MONOMER BioCyc MetaCyc:EG10564-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10564-MONOMER COG COG1168 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1168 DIP DIP-10151N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10151N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/emboj/19.5.831 http://dx.doi.org/10.1093/emboj/19.5.831 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.4.1.8 http://www.genome.jp/dbget-bin/www_bget?EC:4.4.1.8 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M60722 http://www.ebi.ac.uk/ena/data/view/M60722 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 4.4.1.8 http://enzyme.expasy.org/EC/4.4.1.8 EchoBASE EB0559 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0559 EcoGene EG10564 http://www.ecogene.org/geneInfo.php?eg_id=EG10564 EnsemblBacteria AAC74694 http://www.ensemblgenomes.org/id/AAC74694 EnsemblBacteria AAC74694 http://www.ensemblgenomes.org/id/AAC74694 EnsemblBacteria BAA15373 http://www.ensemblgenomes.org/id/BAA15373 EnsemblBacteria BAA15373 http://www.ensemblgenomes.org/id/BAA15373 EnsemblBacteria BAA15373 http://www.ensemblgenomes.org/id/BAA15373 EnsemblBacteria b1622 http://www.ensemblgenomes.org/id/b1622 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004121 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004121 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_function GO:0080146 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0080146 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0009086 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009086 GO_process GO:0043433 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043433 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.640.10 http://www.cathdb.info/version/latest/superfamily/3.40.640.10 Gene3D 3.90.1150.10 http://www.cathdb.info/version/latest/superfamily/3.90.1150.10 GeneID 945937 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945937 HOGENOM HOG000223048 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000223048&db=HOGENOM6 InParanoid P23256 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23256 IntAct P23256 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P23256* IntEnz 4.4.1.8 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.4.1.8 InterPro IPR004839 http://www.ebi.ac.uk/interpro/entry/IPR004839 InterPro IPR015421 http://www.ebi.ac.uk/interpro/entry/IPR015421 InterPro IPR015422 http://www.ebi.ac.uk/interpro/entry/IPR015422 InterPro IPR015424 http://www.ebi.ac.uk/interpro/entry/IPR015424 InterPro IPR027619 http://www.ebi.ac.uk/interpro/entry/IPR027619 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Gene ecj:JW1614 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1614 KEGG_Gene eco:b1622 http://www.genome.jp/dbget-bin/www_bget?eco:b1622 KEGG_Orthology KO:K14155 http://www.genome.jp/dbget-bin/www_bget?KO:K14155 KEGG_Pathway ko00270 http://www.genome.jp/kegg-bin/show_pathway?ko00270 KEGG_Pathway ko00450 http://www.genome.jp/kegg-bin/show_pathway?ko00450 KEGG_Pathway ko00920 http://www.genome.jp/kegg-bin/show_pathway?ko00920 KEGG_Reaction rn:R00782 http://www.genome.jp/dbget-bin/www_bget?rn:R00782 KEGG_Reaction rn:R01285 http://www.genome.jp/dbget-bin/www_bget?rn:R01285 KEGG_Reaction rn:R01286 http://www.genome.jp/dbget-bin/www_bget?rn:R01286 KEGG_Reaction rn:R02408 http://www.genome.jp/dbget-bin/www_bget?rn:R02408 KEGG_Reaction rn:R04941 http://www.genome.jp/dbget-bin/www_bget?rn:R04941 OMA YCTQWDY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YCTQWDY PDB 1D2F http://www.ebi.ac.uk/pdbe-srv/view/entry/1D2F PDBsum 1D2F http://www.ebi.ac.uk/pdbsum/1D2F PSORT swissprot:MALY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MALY_ECOLI PSORT-B swissprot:MALY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MALY_ECOLI PSORT2 swissprot:MALY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MALY_ECOLI Pfam PF00155 http://pfam.xfam.org/family/PF00155 Phobius swissprot:MALY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MALY_ECOLI PhylomeDB P23256 http://phylomedb.org/?seqid=P23256 ProteinModelPortal P23256 http://www.proteinmodelportal.org/query/uniprot/P23256 PubMed 10698925 http://www.ncbi.nlm.nih.gov/pubmed/10698925 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1856179 http://www.ncbi.nlm.nih.gov/pubmed/1856179 PubMed 7665481 http://www.ncbi.nlm.nih.gov/pubmed/7665481 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416139 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416139 RefSeq WP_000459379 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000459379 SMR P23256 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P23256 STRING 511145.b1622 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1622&targetmode=cogs STRING COG1168 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1168&targetmode=cogs SUPFAM SSF53383 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53383 TIGRFAMs TIGR04350 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR04350 UniProtKB MALY_ECOLI http://www.uniprot.org/uniprot/MALY_ECOLI UniProtKB-AC P23256 http://www.uniprot.org/uniprot/P23256 charge swissprot:MALY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MALY_ECOLI eggNOG COG1168 http://eggnogapi.embl.de/nog_data/html/tree/COG1168 eggNOG ENOG4105C87 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C87 epestfind swissprot:MALY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MALY_ECOLI garnier swissprot:MALY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MALY_ECOLI helixturnhelix swissprot:MALY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MALY_ECOLI hmoment swissprot:MALY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MALY_ECOLI iep swissprot:MALY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MALY_ECOLI inforesidue swissprot:MALY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MALY_ECOLI octanol swissprot:MALY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MALY_ECOLI pepcoil swissprot:MALY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MALY_ECOLI pepdigest swissprot:MALY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MALY_ECOLI pepinfo swissprot:MALY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MALY_ECOLI pepnet swissprot:MALY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MALY_ECOLI pepstats swissprot:MALY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MALY_ECOLI pepwheel swissprot:MALY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MALY_ECOLI pepwindow swissprot:MALY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MALY_ECOLI sigcleave swissprot:MALY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MALY_ECOLI ## Database ID URL or Descriptions # AltName CAID_ECOLI Crotonobetainyl-CoA hydratase # BIOPHYSICOCHEMICAL PROPERTIES CAID_ECOLI Kinetic parameters KM=12 uM for crotonobetainyl-CoA {ECO 0000269|PubMed 11551212}; KM=38 uM for crotonyl-CoA {ECO 0000269|PubMed 11551212}; Vmax=186 umol/min/mg enzyme with crotonobetainyl-CoA as substrate {ECO 0000269|PubMed 11551212}; Vmax=0.3 umol/min/mg enzyme with crotonyl-CoA as substrate {ECO 0000269|PubMed 11551212}; # BRENDA 4.2.1.149 2026 # BioGrid 4261692 569 # CATALYTIC ACTIVITY L-carnitinyl-CoA = (E)-4- (trimethylammonio)but-2-enoyl-CoA + H(2)O. {ECO:0000269|PubMed 11551212}. # EcoGene EG11557 caiD # FUNCTION CAID_ECOLI Catalyzes the reversible dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA. {ECO 0000269|PubMed 11551212}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0008809 carnitine racemase activity; EXP:EcoliWiki. # GO_function GO:0016836 hydro-lyase activity; IEA:UniProtKB-HAMAP. # GO_process GO:0042413 carnitine catabolic process; EXP:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.12.10 -; 1. # Gene3D 3.90.226.10 -; 1. # HAMAP MF_01051 CaiD # IntAct P31551 9 # InterPro IPR001753 Crotonase_core_superfam # InterPro IPR014748 Crontonase_C # InterPro IPR018376 Enoyl-CoA_hyd/isom_CS # InterPro IPR022852 Carnitinyl_CoA_dehydratase # InterPro IPR029045 ClpP/crotonase-like_dom # KEGG_Brite ko01000 Enzymes # Organism CAID_ECOLI Escherichia coli (strain K12) # PATHWAY CAID_ECOLI Amine and polyamine metabolism; carnitine metabolism. # PATRIC 32115167 VBIEscCol129921_0035 # PIR D64724 D64724 # PROSITE PS00166 ENOYL_COA_HYDRATASE # Pfam PF00378 ECH_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CAID_ECOLI Carnitinyl-CoA dehydratase # RefSeq NP_414578 NC_000913.3 # RefSeq WP_001295419 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAB96605.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA52114.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the enoyl-CoA hydratase/isomerase family. {ECO 0000305}. # SUBUNIT Homotrimer. {ECO:0000269|PubMed 11551212}. # SUPFAM SSF52096 SSF52096 # eggNOG COG1024 LUCA # eggNOG ENOG4106YT9 Bacteria BLAST swissprot:CAID_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CAID_ECOLI BioCyc ECOL316407:JW0035-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0035-MONOMER BioCyc EcoCyc:CARNRACE-MONOMER http://biocyc.org/getid?id=EcoCyc:CARNRACE-MONOMER BioCyc MetaCyc:CARNRACE-MONOMER http://biocyc.org/getid?id=MetaCyc:CARNRACE-MONOMER COG COG1024 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1024 DOI 10.1021/bi0108812 http://dx.doi.org/10.1021/bi0108812 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1111/j.1365-2958.1994.tb00470.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb00470.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.1.149 http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.149 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X73904 http://www.ebi.ac.uk/ena/data/view/X73904 ENZYME 4.2.1.149 http://enzyme.expasy.org/EC/4.2.1.149 EchoBASE EB1518 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1518 EcoGene EG11557 http://www.ecogene.org/geneInfo.php?eg_id=EG11557 EnsemblBacteria AAC73147 http://www.ensemblgenomes.org/id/AAC73147 EnsemblBacteria AAC73147 http://www.ensemblgenomes.org/id/AAC73147 EnsemblBacteria BAB96605 http://www.ensemblgenomes.org/id/BAB96605 EnsemblBacteria BAB96605 http://www.ensemblgenomes.org/id/BAB96605 EnsemblBacteria BAB96605 http://www.ensemblgenomes.org/id/BAB96605 EnsemblBacteria b0036 http://www.ensemblgenomes.org/id/b0036 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008809 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008809 GO_function GO:0016836 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016836 GO_process GO:0042413 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042413 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.12.10 http://www.cathdb.info/version/latest/superfamily/1.10.12.10 Gene3D 3.90.226.10 http://www.cathdb.info/version/latest/superfamily/3.90.226.10 GeneID 948995 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948995 HAMAP MF_01051 http://hamap.expasy.org/unirule/MF_01051 HOGENOM HOG000027939 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000027939&db=HOGENOM6 InParanoid P31551 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31551 IntAct P31551 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31551* IntEnz 4.2.1.149 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.149 InterPro IPR001753 http://www.ebi.ac.uk/interpro/entry/IPR001753 InterPro IPR014748 http://www.ebi.ac.uk/interpro/entry/IPR014748 InterPro IPR018376 http://www.ebi.ac.uk/interpro/entry/IPR018376 InterPro IPR022852 http://www.ebi.ac.uk/interpro/entry/IPR022852 InterPro IPR029045 http://www.ebi.ac.uk/interpro/entry/IPR029045 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0035 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0035 KEGG_Gene eco:b0036 http://www.genome.jp/dbget-bin/www_bget?eco:b0036 KEGG_Orthology KO:K08299 http://www.genome.jp/dbget-bin/www_bget?KO:K08299 OMA MAAHFRI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MAAHFRI PROSITE PS00166 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00166 PSORT swissprot:CAID_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CAID_ECOLI PSORT-B swissprot:CAID_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CAID_ECOLI PSORT2 swissprot:CAID_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CAID_ECOLI Pfam PF00378 http://pfam.xfam.org/family/PF00378 Phobius swissprot:CAID_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CAID_ECOLI PhylomeDB P31551 http://phylomedb.org/?seqid=P31551 ProteinModelPortal P31551 http://www.proteinmodelportal.org/query/uniprot/P31551 PubMed 11551212 http://www.ncbi.nlm.nih.gov/pubmed/11551212 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7815937 http://www.ncbi.nlm.nih.gov/pubmed/7815937 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414578 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414578 RefSeq WP_001295419 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295419 SMR P31551 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31551 STRING 511145.b0036 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0036&targetmode=cogs STRING COG1024 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1024&targetmode=cogs SUPFAM SSF52096 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52096 UniProtKB CAID_ECOLI http://www.uniprot.org/uniprot/CAID_ECOLI UniProtKB-AC P31551 http://www.uniprot.org/uniprot/P31551 charge swissprot:CAID_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CAID_ECOLI eggNOG COG1024 http://eggnogapi.embl.de/nog_data/html/tree/COG1024 eggNOG ENOG4106YT9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106YT9 epestfind swissprot:CAID_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CAID_ECOLI garnier swissprot:CAID_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CAID_ECOLI helixturnhelix swissprot:CAID_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CAID_ECOLI hmoment swissprot:CAID_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CAID_ECOLI iep swissprot:CAID_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CAID_ECOLI inforesidue swissprot:CAID_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CAID_ECOLI octanol swissprot:CAID_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CAID_ECOLI pepcoil swissprot:CAID_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CAID_ECOLI pepdigest swissprot:CAID_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CAID_ECOLI pepinfo swissprot:CAID_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CAID_ECOLI pepnet swissprot:CAID_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CAID_ECOLI pepstats swissprot:CAID_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CAID_ECOLI pepwheel swissprot:CAID_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CAID_ECOLI pepwindow swissprot:CAID_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CAID_ECOLI sigcleave swissprot:CAID_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CAID_ECOLI ## Database ID URL or Descriptions # BioGrid 4261967 28 # EcoGene EG11100 ybaB # FUNCTION YBAB_ECOLI Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. {ECO 0000255|HAMAP-Rule MF_00274}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0043590 bacterial nucleoid; IEA:UniProtKB-HAMAP. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_component GO:0043226 organelle # GOslim_function GO:0003677 DNA binding # Gene3D 3.30.1310.10 -; 1. # HAMAP MF_00274 DNA_YbaB_EbfC # IntAct P0A8B5 12 # InterPro IPR004401 YbaB/EbfC # Organism YBAB_ECOLI Escherichia coli (strain K12) # PATRIC 32116099 VBIEscCol129921_0491 # PDB 1PUG X-ray; 2.20 A; A/B/C/D=1-109 # PIR A30371 QQECZG # PIRSF PIRSF004555 UCP004555 # Pfam PF02575 YbaB_DNA_bd # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Nucleoid-associated protein YbaB {ECO:0000255|HAMAP-Rule MF_00274} # RefSeq NP_415004 NC_000913.3 # RefSeq WP_000467098 NZ_LN832404.1 # SIMILARITY Belongs to the YbaB/EbfC family. {ECO:0000255|HAMAP- Rule MF_00274}. # SUBCELLULAR LOCATION YBAB_ECOLI Cytoplasm, nucleoid {ECO 0000255|HAMAP- Rule MF_00274}. # SUBUNIT YBAB_ECOLI Homodimer. {ECO 0000255|HAMAP-Rule MF_00274, ECO 0000269|PubMed 19594923, ECO 0000269|Ref.7}. # SUPFAM SSF82607 SSF82607 # TIGRFAMs TIGR00103 DNA_YbaB_EbfC # eggNOG COG0718 LUCA BLAST swissprot:YBAB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBAB_ECOLI BioCyc ECOL316407:JW0460-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0460-MONOMER BioCyc EcoCyc:EG11100-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11100-MONOMER COG COG0718 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0718 DIP DIP-48059N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48059N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/14.20.8091 http://dx.doi.org/10.1093/nar/14.20.8091 DOI 10.1093/nar/17.17.6781 http://dx.doi.org/10.1093/nar/17.17.6781 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1186/1471-2180-9-137 http://dx.doi.org/10.1186/1471-2180-9-137 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M38777 http://www.ebi.ac.uk/ena/data/view/M38777 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X04487 http://www.ebi.ac.uk/ena/data/view/X04487 EMBL X15761 http://www.ebi.ac.uk/ena/data/view/X15761 EchoBASE EB1092 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1092 EcoGene EG11100 http://www.ecogene.org/geneInfo.php?eg_id=EG11100 EnsemblBacteria AAC73573 http://www.ensemblgenomes.org/id/AAC73573 EnsemblBacteria AAC73573 http://www.ensemblgenomes.org/id/AAC73573 EnsemblBacteria BAE76250 http://www.ensemblgenomes.org/id/BAE76250 EnsemblBacteria BAE76250 http://www.ensemblgenomes.org/id/BAE76250 EnsemblBacteria BAE76250 http://www.ensemblgenomes.org/id/BAE76250 EnsemblBacteria b0471 http://www.ensemblgenomes.org/id/b0471 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0043590 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043590 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0043226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 Gene3D 3.30.1310.10 http://www.cathdb.info/version/latest/superfamily/3.30.1310.10 GeneID 945104 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945104 HAMAP MF_00274 http://hamap.expasy.org/unirule/MF_00274 HOGENOM HOG000293239 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000293239&db=HOGENOM6 InParanoid P0A8B5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8B5 IntAct P0A8B5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8B5* InterPro IPR004401 http://www.ebi.ac.uk/interpro/entry/IPR004401 KEGG_Gene ecj:JW0460 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0460 KEGG_Gene eco:b0471 http://www.genome.jp/dbget-bin/www_bget?eco:b0471 KEGG_Orthology KO:K09747 http://www.genome.jp/dbget-bin/www_bget?KO:K09747 MINT MINT-1219994 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1219994 OMA VTMTGSH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VTMTGSH PDB 1PUG http://www.ebi.ac.uk/pdbe-srv/view/entry/1PUG PDBsum 1PUG http://www.ebi.ac.uk/pdbsum/1PUG PSORT swissprot:YBAB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBAB_ECOLI PSORT-B swissprot:YBAB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBAB_ECOLI PSORT2 swissprot:YBAB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBAB_ECOLI Pfam PF02575 http://pfam.xfam.org/family/PF02575 Phobius swissprot:YBAB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBAB_ECOLI PhylomeDB P0A8B5 http://phylomedb.org/?seqid=P0A8B5 ProteinModelPortal P0A8B5 http://www.proteinmodelportal.org/query/uniprot/P0A8B5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1698765 http://www.ncbi.nlm.nih.gov/pubmed/1698765 PubMed 19594923 http://www.ncbi.nlm.nih.gov/pubmed/19594923 PubMed 2674903 http://www.ncbi.nlm.nih.gov/pubmed/2674903 PubMed 3534795 http://www.ncbi.nlm.nih.gov/pubmed/3534795 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415004 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415004 RefSeq WP_000467098 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000467098 SMR P0A8B5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8B5 STRING 511145.b0471 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0471&targetmode=cogs STRING COG0718 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0718&targetmode=cogs SUPFAM SSF82607 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF82607 TIGRFAMs TIGR00103 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00103 UniProtKB YBAB_ECOLI http://www.uniprot.org/uniprot/YBAB_ECOLI UniProtKB-AC P0A8B5 http://www.uniprot.org/uniprot/P0A8B5 charge swissprot:YBAB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBAB_ECOLI eggNOG COG0718 http://eggnogapi.embl.de/nog_data/html/tree/COG0718 epestfind swissprot:YBAB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBAB_ECOLI garnier swissprot:YBAB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBAB_ECOLI helixturnhelix swissprot:YBAB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBAB_ECOLI hmoment swissprot:YBAB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBAB_ECOLI iep swissprot:YBAB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBAB_ECOLI inforesidue swissprot:YBAB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBAB_ECOLI octanol swissprot:YBAB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBAB_ECOLI pepcoil swissprot:YBAB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBAB_ECOLI pepdigest swissprot:YBAB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBAB_ECOLI pepinfo swissprot:YBAB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBAB_ECOLI pepnet swissprot:YBAB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBAB_ECOLI pepstats swissprot:YBAB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBAB_ECOLI pepwheel swissprot:YBAB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBAB_ECOLI pepwindow swissprot:YBAB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBAB_ECOLI sigcleave swissprot:YBAB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBAB_ECOLI ## Database ID URL or Descriptions # BioGrid 4262110 24 # CDD cd07153 Fur_like # EcoGene EG10359 fur # FUNCTION FUR_ECOLI Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes. Regulates the expression of several outer-membrane proteins including the iron transport operon. {ECO 0000269|PubMed 2823881}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_function GO:0008270 zinc ion binding; IDA:EcoliWiki. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # IntAct P0A9A9 50 # InterPro IPR002481 FUR # InterPro IPR011991 WHTH_DNA-bd_dom # KEGG_Brite ko03000 Transcription factors # MISCELLANEOUS FUR_ECOLI Activated by cadmium, cobalt, copper, and manganese ions, but not zinc ions. # Organism FUR_ECOLI Escherichia coli (strain K12) # PATRIC 32116559 VBIEscCol129921_0712 # PDB 2FU4 X-ray; 1.80 A; A/B=1-83 # PIR S07308 S07308 # Pfam PF01475 FUR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FUR_ECOLI Ferric uptake regulation protein # RefSeq NP_415209 NC_000913.3 # RefSeq WP_000131702 NZ_LN832404.1 # SIMILARITY Belongs to the Fur family. {ECO 0000305}. # SUBCELLULAR LOCATION FUR_ECOLI Cytoplasm. # SUBUNIT Homodimer. {ECO 0000250}. # SUPFAM SSF46785 SSF46785 # eggNOG COG0735 LUCA # eggNOG ENOG41090R7 Bacteria BLAST swissprot:FUR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FUR_ECOLI BioCyc ECOL316407:JW0669-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0669-MONOMER BioCyc EcoCyc:PD00260 http://biocyc.org/getid?id=EcoCyc:PD00260 COG COG0735 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0735 DIP DIP-31858N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31858N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1007/BF00383321 http://dx.doi.org/10.1007/BF00383321 DOI 10.1021/bi00247a016 http://dx.doi.org/10.1021/bi00247a016 DOI 10.1021/bi00391a039 http://dx.doi.org/10.1021/bi00391a039 DOI 10.1021/bi9902283 http://dx.doi.org/10.1021/bi9902283 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1432-1033.1991.tb15880.x http://dx.doi.org/10.1111/j.1432-1033.1991.tb15880.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1266/ggs.82.291 http://dx.doi.org/10.1266/ggs.82.291 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X02589 http://www.ebi.ac.uk/ena/data/view/X02589 EchoBASE EB0354 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0354 EcoGene EG10359 http://www.ecogene.org/geneInfo.php?eg_id=EG10359 EnsemblBacteria AAC73777 http://www.ensemblgenomes.org/id/AAC73777 EnsemblBacteria AAC73777 http://www.ensemblgenomes.org/id/AAC73777 EnsemblBacteria BAA35331 http://www.ensemblgenomes.org/id/BAA35331 EnsemblBacteria BAA35331 http://www.ensemblgenomes.org/id/BAA35331 EnsemblBacteria BAA35331 http://www.ensemblgenomes.org/id/BAA35331 EnsemblBacteria b0683 http://www.ensemblgenomes.org/id/b0683 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 945295 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945295 HOGENOM HOG000014144 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000014144&db=HOGENOM6 InParanoid P0A9A9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9A9 IntAct P0A9A9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9A9* InterPro IPR002481 http://www.ebi.ac.uk/interpro/entry/IPR002481 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW0669 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0669 KEGG_Gene eco:b0683 http://www.genome.jp/dbget-bin/www_bget?eco:b0683 KEGG_Orthology KO:K03711 http://www.genome.jp/dbget-bin/www_bget?KO:K03711 MINT MINT-1312814 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1312814 OMA DERSDIG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DERSDIG PDB 2FU4 http://www.ebi.ac.uk/pdbe-srv/view/entry/2FU4 PDBsum 2FU4 http://www.ebi.ac.uk/pdbsum/2FU4 PSORT swissprot:FUR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FUR_ECOLI PSORT-B swissprot:FUR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FUR_ECOLI PSORT2 swissprot:FUR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FUR_ECOLI Pfam PF01475 http://pfam.xfam.org/family/PF01475 Phobius swissprot:FUR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FUR_ECOLI PhylomeDB P0A9A9 http://phylomedb.org/?seqid=P0A9A9 ProteinModelPortal P0A9A9 http://www.proteinmodelportal.org/query/uniprot/P0A9A9 PubMed 10387106 http://www.ncbi.nlm.nih.gov/pubmed/10387106 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17895580 http://www.ncbi.nlm.nih.gov/pubmed/17895580 PubMed 1868094 http://www.ncbi.nlm.nih.gov/pubmed/1868094 PubMed 2015825 http://www.ncbi.nlm.nih.gov/pubmed/2015825 PubMed 2823881 http://www.ncbi.nlm.nih.gov/pubmed/2823881 PubMed 2993806 http://www.ncbi.nlm.nih.gov/pubmed/2993806 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_415209 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415209 RefSeq WP_000131702 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000131702 SMR P0A9A9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9A9 STRING 511145.b0683 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0683&targetmode=cogs STRING COG0735 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0735&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SWISS-2DPAGE P0A9A9 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A9A9 UniProtKB FUR_ECOLI http://www.uniprot.org/uniprot/FUR_ECOLI UniProtKB-AC P0A9A9 http://www.uniprot.org/uniprot/P0A9A9 charge swissprot:FUR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FUR_ECOLI eggNOG COG0735 http://eggnogapi.embl.de/nog_data/html/tree/COG0735 eggNOG ENOG41090R7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41090R7 epestfind swissprot:FUR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FUR_ECOLI garnier swissprot:FUR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FUR_ECOLI helixturnhelix swissprot:FUR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FUR_ECOLI hmoment swissprot:FUR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FUR_ECOLI iep swissprot:FUR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FUR_ECOLI inforesidue swissprot:FUR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FUR_ECOLI octanol swissprot:FUR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FUR_ECOLI pepcoil swissprot:FUR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FUR_ECOLI pepdigest swissprot:FUR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FUR_ECOLI pepinfo swissprot:FUR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FUR_ECOLI pepnet swissprot:FUR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FUR_ECOLI pepstats swissprot:FUR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FUR_ECOLI pepwheel swissprot:FUR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FUR_ECOLI pepwindow swissprot:FUR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FUR_ECOLI sigcleave swissprot:FUR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FUR_ECOLI ## Database ID URL or Descriptions # AltName SSB_ECOLI Helix-destabilizing protein # BioGrid 4262671 106 # ENZYME REGULATION The C-terminal tail exerts an inhibitory effect on ssDNA binding. {ECO:0000269|PubMed 20360609}. # EcoGene EG10976 ssb # FUNCTION SSB_ECOLI Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. Acts as a sliding platform that migrates on DNA via reptation. {ECO 0000255|HAMAP-Rule MF_00984, ECO 0000269|PubMed 18937104, ECO 0000269|PubMed 20360609, ECO 0000269|PubMed 21784244}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003697 single-stranded DNA binding; IDA:EcoCyc. # GO_function GO:0008047 enzyme activator activity; IMP:UniProtKB. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0000725 recombinational repair; TAS:EcoCyc. # GO_process GO:0006260 DNA replication; IEA:UniProtKB-HAMAP. # GO_process GO:0006298 mismatch repair; TAS:EcoCyc. # GO_process GO:0009432 SOS response; TAS:EcoCyc. # GO_process GO:0043085 positive regulation of catalytic activity; IMP:UniProtKB. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0030234 enzyme regulator activity # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # HAMAP MF_00984 SSB # INTERACTION SSB_ECOLI P27296 dinG; NbExp=2; IntAct=EBI-1118620, EBI-1114590; P0ABS5 dnaG; NbExp=2; IntAct=EBI-1118620, EBI-549259; P06710 dnaX; NbExp=2; IntAct=EBI-1118620, EBI-549140; P28905 holC; NbExp=9; IntAct=EBI-1118620, EBI-549169; P17888 priA; NbExp=2; IntAct=EBI-1118620, EBI-552050; # IntAct P0AGE0 12 # InterPro IPR000424 Primosome_PriB/ssb # InterPro IPR011344 ssDNA-bd # InterPro IPR012340 NA-bd_OB-fold # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko03032 DNA replication proteins # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko03030 DNA replication # KEGG_Pathway ko03430 Mismatch repair # KEGG_Pathway ko03440 Homologous recombination # Organism SSB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10302 PTHR10302 # PATRIC 32123663 VBIEscCol129921_4180 # PDB 1EQQ X-ray; 3.20 A; A/B/C/D=1-178 # PDB 1EYG X-ray; 2.80 A; A/B/C/D=1-116 # PDB 1KAW X-ray; 2.90 A; A/B/C/D=2-136 # PDB 1QVC X-ray; 2.20 A; A/B/C/D=2-146 # PDB 1SRU X-ray; 3.30 A; A/B/C/D=1-113 # PDB 3C94 X-ray; 2.70 A; B/C=170-178 # PDB 3SXU X-ray; 1.85 A; C=175-178 # PDB 3UF7 X-ray; 1.20 A; B/C=170-178 # PDB 4MZ9 X-ray; 2.20 A; A/B/C/D=1-178 # PDB 4Z0U X-ray; 2.00 A; D/E=170-178 # PIR B65214 DDEC # PIRSF PIRSF002070 SSB # PROSITE PS50935 SSB # PTM SSB_ECOLI Phosphorylated on tyrosine residue(s). {ECO 0000269|PubMed 16549871}. # Pfam PF00436 SSB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Single-stranded DNA-binding protein {ECO:0000255|HAMAP-Rule MF_00984} # RefSeq NP_418483 NC_000913.3 # RefSeq WP_000168305 NZ_LN832404.1 # SIMILARITY Contains 1 SSB domain. {ECO:0000255|HAMAP- Rule MF_00984}. # SUBUNIT SSB_ECOLI Homotetramer. Interacts, via its C-terminus, with several proteins involved in DNA metabolism such as DnaG, HolC, PriA, PriB, RecO, RecQ and SbcB. {ECO 0000255|HAMAP-Rule MF_00984, ECO 0000269|PubMed 10782989, ECO 0000269|PubMed 10932248, ECO 0000269|PubMed 15576682, ECO 0000269|PubMed 17483090, ECO 0000269|PubMed 18591666, ECO 0000269|PubMed 20018747, ECO 0000269|PubMed 23430154, ECO 0000269|PubMed 23963891, ECO 0000269|PubMed 7962001, ECO 0000269|PubMed 9192620, ECO 0000269|PubMed 9545254}. # SUPFAM SSF50249 SSF50249 # TIGRFAMs TIGR00621 ssb # eggNOG COG0629 LUCA # eggNOG ENOG4108UUM Bacteria BLAST swissprot:SSB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SSB_ECOLI BioCyc ECOL316407:JW4020-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4020-MONOMER BioCyc EcoCyc:EG10976-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10976-MONOMER COG COG0629 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0629 DIP DIP-35980N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35980N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1007/s10930-013-9509-y http://dx.doi.org/10.1007/s10930-013-9509-y DOI 10.1016/0014-5793(87)80844-X http://dx.doi.org/10.1016/0014-5793(87)80844-X DOI 10.1016/0022-2836(91)90611-9 http://dx.doi.org/10.1016/0022-2836(91)90611-9 DOI 10.1016/j.cell.2011.06.036 http://dx.doi.org/10.1016/j.cell.2011.06.036 DOI 10.1038/77943 http://dx.doi.org/10.1038/77943 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0800741105 http://dx.doi.org/10.1073/pnas.0800741105 DOI 10.1073/pnas.0909191107 http://dx.doi.org/10.1073/pnas.0909191107 DOI 10.1073/pnas.78.7.4274 http://dx.doi.org/10.1073/pnas.78.7.4274 DOI 10.1073/pnas.80.18.5480 http://dx.doi.org/10.1073/pnas.80.18.5480 DOI 10.1073/pnas.94.13.6652 http://dx.doi.org/10.1073/pnas.94.13.6652 DOI 10.1074/jbc.M110.118273 http://dx.doi.org/10.1074/jbc.M110.118273 DOI 10.1074/jbc.M608011200 http://dx.doi.org/10.1074/jbc.M608011200 DOI 10.1080/10409230802341296 http://dx.doi.org/10.1080/10409230802341296 DOI 10.1093/emboj/17.8.2436 http://dx.doi.org/10.1093/emboj/17.8.2436 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1093/nar/gkh980 http://dx.doi.org/10.1093/nar/gkh980 DOI 10.1093/nar/gkj514 http://dx.doi.org/10.1093/nar/gkj514 DOI 10.1093/nar/gkt107 http://dx.doi.org/10.1093/nar/gkt107 DOI 10.1111/j.1432-1033.1982.tb19784.x http://dx.doi.org/10.1111/j.1432-1033.1982.tb19784.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1515/BC.2000.025 http://dx.doi.org/10.1515/BC.2000.025 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01704 http://www.ebi.ac.uk/ena/data/view/J01704 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0969 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0969 EcoGene EG10976 http://www.ecogene.org/geneInfo.php?eg_id=EG10976 EnsemblBacteria AAC77029 http://www.ensemblgenomes.org/id/AAC77029 EnsemblBacteria AAC77029 http://www.ensemblgenomes.org/id/AAC77029 EnsemblBacteria BAE78061 http://www.ensemblgenomes.org/id/BAE78061 EnsemblBacteria BAE78061 http://www.ensemblgenomes.org/id/BAE78061 EnsemblBacteria BAE78061 http://www.ensemblgenomes.org/id/BAE78061 EnsemblBacteria b4059 http://www.ensemblgenomes.org/id/b4059 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003697 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003697 GO_function GO:0008047 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008047 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0000725 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000725 GO_process GO:0006260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260 GO_process GO:0006298 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006298 GO_process GO:0009432 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009432 GO_process GO:0043085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043085 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 948570 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948570 HAMAP MF_00984 http://hamap.expasy.org/unirule/MF_00984 HOGENOM HOG000106483 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000106483&db=HOGENOM6 InParanoid P0AGE0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGE0 IntAct P0AGE0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AGE0* InterPro IPR000424 http://www.ebi.ac.uk/interpro/entry/IPR000424 InterPro IPR011344 http://www.ebi.ac.uk/interpro/entry/IPR011344 InterPro IPR012340 http://www.ebi.ac.uk/interpro/entry/IPR012340 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko03032 http://www.genome.jp/dbget-bin/www_bget?ko03032 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW4020 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4020 KEGG_Gene eco:b4059 http://www.genome.jp/dbget-bin/www_bget?eco:b4059 KEGG_Orthology KO:K03111 http://www.genome.jp/dbget-bin/www_bget?KO:K03111 KEGG_Pathway ko03030 http://www.genome.jp/kegg-bin/show_pathway?ko03030 KEGG_Pathway ko03430 http://www.genome.jp/kegg-bin/show_pathway?ko03430 KEGG_Pathway ko03440 http://www.genome.jp/kegg-bin/show_pathway?ko03440 MINT MINT-8298796 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8298796 OMA QQYNEPP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QQYNEPP PANTHER PTHR10302 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10302 PDB 1EQQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1EQQ PDB 1EYG http://www.ebi.ac.uk/pdbe-srv/view/entry/1EYG PDB 1KAW http://www.ebi.ac.uk/pdbe-srv/view/entry/1KAW PDB 1QVC http://www.ebi.ac.uk/pdbe-srv/view/entry/1QVC PDB 1SRU http://www.ebi.ac.uk/pdbe-srv/view/entry/1SRU PDB 3C94 http://www.ebi.ac.uk/pdbe-srv/view/entry/3C94 PDB 3SXU http://www.ebi.ac.uk/pdbe-srv/view/entry/3SXU PDB 3UF7 http://www.ebi.ac.uk/pdbe-srv/view/entry/3UF7 PDB 4MZ9 http://www.ebi.ac.uk/pdbe-srv/view/entry/4MZ9 PDB 4Z0U http://www.ebi.ac.uk/pdbe-srv/view/entry/4Z0U PDBsum 1EQQ http://www.ebi.ac.uk/pdbsum/1EQQ PDBsum 1EYG http://www.ebi.ac.uk/pdbsum/1EYG PDBsum 1KAW http://www.ebi.ac.uk/pdbsum/1KAW PDBsum 1QVC http://www.ebi.ac.uk/pdbsum/1QVC PDBsum 1SRU http://www.ebi.ac.uk/pdbsum/1SRU PDBsum 3C94 http://www.ebi.ac.uk/pdbsum/3C94 PDBsum 3SXU http://www.ebi.ac.uk/pdbsum/3SXU PDBsum 3UF7 http://www.ebi.ac.uk/pdbsum/3UF7 PDBsum 4MZ9 http://www.ebi.ac.uk/pdbsum/4MZ9 PDBsum 4Z0U http://www.ebi.ac.uk/pdbsum/4Z0U PROSITE PS50935 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50935 PSORT swissprot:SSB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SSB_ECOLI PSORT-B swissprot:SSB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SSB_ECOLI PSORT2 swissprot:SSB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SSB_ECOLI Pfam PF00436 http://pfam.xfam.org/family/PF00436 Phobius swissprot:SSB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SSB_ECOLI PhylomeDB P0AGE0 http://phylomedb.org/?seqid=P0AGE0 ProteinModelPortal P0AGE0 http://www.proteinmodelportal.org/query/uniprot/P0AGE0 PubMed 10782989 http://www.ncbi.nlm.nih.gov/pubmed/10782989 PubMed 10932248 http://www.ncbi.nlm.nih.gov/pubmed/10932248 PubMed 15576682 http://www.ncbi.nlm.nih.gov/pubmed/15576682 PubMed 16549871 http://www.ncbi.nlm.nih.gov/pubmed/16549871 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17483090 http://www.ncbi.nlm.nih.gov/pubmed/17483090 PubMed 18591666 http://www.ncbi.nlm.nih.gov/pubmed/18591666 PubMed 18937104 http://www.ncbi.nlm.nih.gov/pubmed/18937104 PubMed 1988680 http://www.ncbi.nlm.nih.gov/pubmed/1988680 PubMed 20018747 http://www.ncbi.nlm.nih.gov/pubmed/20018747 PubMed 20360609 http://www.ncbi.nlm.nih.gov/pubmed/20360609 PubMed 2087220 http://www.ncbi.nlm.nih.gov/pubmed/2087220 PubMed 21784244 http://www.ncbi.nlm.nih.gov/pubmed/21784244 PubMed 23430154 http://www.ncbi.nlm.nih.gov/pubmed/23430154 PubMed 23963891 http://www.ncbi.nlm.nih.gov/pubmed/23963891 PubMed 3301414 http://www.ncbi.nlm.nih.gov/pubmed/3301414 PubMed 6270666 http://www.ncbi.nlm.nih.gov/pubmed/6270666 PubMed 6351061 http://www.ncbi.nlm.nih.gov/pubmed/6351061 PubMed 6363409 http://www.ncbi.nlm.nih.gov/pubmed/6363409 PubMed 6384214 http://www.ncbi.nlm.nih.gov/pubmed/6384214 PubMed 7042342 http://www.ncbi.nlm.nih.gov/pubmed/7042342 PubMed 7962001 http://www.ncbi.nlm.nih.gov/pubmed/7962001 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9139905 http://www.ncbi.nlm.nih.gov/pubmed/9139905 PubMed 9192620 http://www.ncbi.nlm.nih.gov/pubmed/9192620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9545254 http://www.ncbi.nlm.nih.gov/pubmed/9545254 RefSeq NP_418483 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418483 RefSeq WP_000168305 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000168305 SMR P0AGE0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AGE0 STRING 511145.b4059 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4059&targetmode=cogs STRING COG0629 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0629&targetmode=cogs SUPFAM SSF50249 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50249 SWISS-2DPAGE P0AGE0 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AGE0 TIGRFAMs TIGR00621 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00621 UniProtKB SSB_ECOLI http://www.uniprot.org/uniprot/SSB_ECOLI UniProtKB-AC P0AGE0 http://www.uniprot.org/uniprot/P0AGE0 charge swissprot:SSB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SSB_ECOLI eggNOG COG0629 http://eggnogapi.embl.de/nog_data/html/tree/COG0629 eggNOG ENOG4108UUM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UUM epestfind swissprot:SSB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SSB_ECOLI garnier swissprot:SSB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SSB_ECOLI helixturnhelix swissprot:SSB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SSB_ECOLI hmoment swissprot:SSB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SSB_ECOLI iep swissprot:SSB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SSB_ECOLI inforesidue swissprot:SSB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SSB_ECOLI octanol swissprot:SSB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SSB_ECOLI pepcoil swissprot:SSB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SSB_ECOLI pepdigest swissprot:SSB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SSB_ECOLI pepinfo swissprot:SSB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SSB_ECOLI pepnet swissprot:SSB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SSB_ECOLI pepstats swissprot:SSB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SSB_ECOLI pepwheel swissprot:SSB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SSB_ECOLI pepwindow swissprot:SSB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SSB_ECOLI sigcleave swissprot:SSB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SSB_ECOLI ## Database ID URL or Descriptions # AltName RIMJ_ECOLI Acetylating enzyme for N-terminal of ribosomal protein S5 # BioGrid 4260076 16 # CATALYTIC ACTIVITY RIMJ_ECOLI Acetyl-CoA + ribosomal-protein L-alanine = CoA + ribosomal-protein N-acetyl-L-alanine. # EcoGene EG10851 rimJ # FUNCTION RIMJ_ECOLI This enzyme acetylates the N-terminal alanine of ribosomal protein S5. Plays also a role in the temperature regulation of pap pilin transcription. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008080 N-acetyltransferase activity; IMP:EcoliWiki. # GO_function GO:0008999 ribosomal-protein-alanine N-acetyltransferase activity; IMP:EcoliWiki. # GO_process GO:0006464 cellular protein modification process; IMP:EcoliWiki. # GO_process GO:0006474 N-terminal protein amino acid acetylation; IMP:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0006464 cellular protein modification process # Gene3D 3.40.630.30 -; 1. # IntAct P0A948 17 # InterPro IPR000182 GNAT_dom # InterPro IPR016181 Acyl_CoA_acyltransferase # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # Organism RIMJ_ECOLI Escherichia coli (strain K12) # PATRIC 32117371 VBIEscCol129921_1108 # PIR S01084 S01084 # PROSITE PS51186 GNAT # Pfam PF13302 Acetyltransf_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RIMJ_ECOLI Ribosomal-protein-alanine acetyltransferase # RefSeq NP_415584 NC_000913.3 # RefSeq WP_000468186 NZ_LN832404.1 # SIMILARITY Belongs to the acetyltransferase family. RimJ subfamily. {ECO 0000305}. # SIMILARITY Contains 1 N-acetyltransferase domain. {ECO:0000255|PROSITE-ProRule PRU00532}. # SUBCELLULAR LOCATION RIMJ_ECOLI Cytoplasm. # SUPFAM SSF55729 SSF55729 # eggNOG COG1670 LUCA # eggNOG ENOG4105D9U Bacteria BLAST swissprot:RIMJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RIMJ_ECOLI BioCyc ECOL316407:JW1053-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1053-MONOMER BioCyc EcoCyc:EG10851-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10851-MONOMER BioCyc MetaCyc:EG10851-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10851-MONOMER COG COG1670 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1670 DIP DIP-35985N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35985N DOI 10.1007/BF00331153 http://dx.doi.org/10.1007/BF00331153 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.128 http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.128 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M99278 http://www.ebi.ac.uk/ena/data/view/M99278 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X06118 http://www.ebi.ac.uk/ena/data/view/X06118 ENZYME 2.3.1.128 http://enzyme.expasy.org/EC/2.3.1.128 EchoBASE EB0844 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0844 EcoGene EG10851 http://www.ecogene.org/geneInfo.php?eg_id=EG10851 EnsemblBacteria AAC74150 http://www.ensemblgenomes.org/id/AAC74150 EnsemblBacteria AAC74150 http://www.ensemblgenomes.org/id/AAC74150 EnsemblBacteria BAA35874 http://www.ensemblgenomes.org/id/BAA35874 EnsemblBacteria BAA35874 http://www.ensemblgenomes.org/id/BAA35874 EnsemblBacteria BAA35874 http://www.ensemblgenomes.org/id/BAA35874 EnsemblBacteria b1066 http://www.ensemblgenomes.org/id/b1066 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008080 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008080 GO_function GO:0008999 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008999 GO_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GO_process GO:0006474 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006474 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 Gene3D 3.40.630.30 http://www.cathdb.info/version/latest/superfamily/3.40.630.30 GeneID 946910 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946910 HOGENOM HOG000078527 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000078527&db=HOGENOM6 InParanoid P0A948 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A948 IntAct P0A948 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A948* IntEnz 2.3.1.128 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.128 InterPro IPR000182 http://www.ebi.ac.uk/interpro/entry/IPR000182 InterPro IPR016181 http://www.ebi.ac.uk/interpro/entry/IPR016181 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW1053 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1053 KEGG_Gene eco:b1066 http://www.genome.jp/dbget-bin/www_bget?eco:b1066 KEGG_Orthology KO:K03790 http://www.genome.jp/dbget-bin/www_bget?KO:K03790 OMA LCINGVW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LCINGVW PROSITE PS51186 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51186 PSORT swissprot:RIMJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RIMJ_ECOLI PSORT-B swissprot:RIMJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RIMJ_ECOLI PSORT2 swissprot:RIMJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RIMJ_ECOLI Pfam PF13302 http://pfam.xfam.org/family/PF13302 Phobius swissprot:RIMJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RIMJ_ECOLI PhylomeDB P0A948 http://phylomedb.org/?seqid=P0A948 ProteinModelPortal P0A948 http://www.proteinmodelportal.org/query/uniprot/P0A948 PubMed 1356970 http://www.ncbi.nlm.nih.gov/pubmed/1356970 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2828880 http://www.ncbi.nlm.nih.gov/pubmed/2828880 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415584 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415584 RefSeq WP_000468186 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000468186 SMR P0A948 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A948 STRING 511145.b1066 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1066&targetmode=cogs STRING COG1670 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1670&targetmode=cogs SUPFAM SSF55729 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55729 UniProtKB RIMJ_ECOLI http://www.uniprot.org/uniprot/RIMJ_ECOLI UniProtKB-AC P0A948 http://www.uniprot.org/uniprot/P0A948 charge swissprot:RIMJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RIMJ_ECOLI eggNOG COG1670 http://eggnogapi.embl.de/nog_data/html/tree/COG1670 eggNOG ENOG4105D9U http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D9U epestfind swissprot:RIMJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RIMJ_ECOLI garnier swissprot:RIMJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RIMJ_ECOLI helixturnhelix swissprot:RIMJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RIMJ_ECOLI hmoment swissprot:RIMJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RIMJ_ECOLI iep swissprot:RIMJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RIMJ_ECOLI inforesidue swissprot:RIMJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RIMJ_ECOLI octanol swissprot:RIMJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RIMJ_ECOLI pepcoil swissprot:RIMJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RIMJ_ECOLI pepdigest swissprot:RIMJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RIMJ_ECOLI pepinfo swissprot:RIMJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RIMJ_ECOLI pepnet swissprot:RIMJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RIMJ_ECOLI pepstats swissprot:RIMJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RIMJ_ECOLI pepwheel swissprot:RIMJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RIMJ_ECOLI pepwindow swissprot:RIMJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RIMJ_ECOLI sigcleave swissprot:RIMJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RIMJ_ECOLI ## Database ID URL or Descriptions # AltName Trehalose operon repressor {ECO:0000303|PubMed 9148912} # BioGrid 4260956 9 # CDD cd01392 HTH_LacI # DISRUPTION PHENOTYPE Cells lacking this gene are constitutive in the expression of the treBC operon. {ECO:0000269|PubMed 7608078}. # EcoGene EG12202 treR # FUNCTION TRER_ECOLI Repressor of the treBC operon. It is able to bind trehalose-6-phosphate and trehalose. {ECO 0000269|PubMed 7608078, ECO 0000269|PubMed 9148912}. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0005991 trehalose metabolic process; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; ISS:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.260.40 -; 1. # INDUCTION Probably induced by trehalose-6-phosphate. {ECO:0000305|PubMed 7608078}. # IntAct P36673 10 # InterPro IPR000843 HTH_LacI # InterPro IPR010982 Lambda_DNA-bd_dom # InterPro IPR012771 Trehalos_R_gpbac # InterPro IPR028082 Peripla_BP_I # KEGG_Brite ko03000 Transcription factors # Organism TRER_ECOLI Escherichia coli (strain K12) # PATRIC 32124057 VBIEscCol129921_4373 # PDB 4XXH X-ray; 2.40 A; A/B=61-315 # PIR S56467 S56467 # PRINTS PR00036 HTHLACI # PROSITE PS00356 HTH_LACI_1 # PROSITE PS50932 HTH_LACI_2 # Pfam PF00356 LacI # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HTH-type transcriptional regulator TreR {ECO:0000303|PubMed 9148912} # RefSeq NP_418662 NC_000913.3 # RefSeq WP_001181307 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lacI-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00111}. # SMART SM00354 HTH_LACI # SUBUNIT TRER_ECOLI Homodimer. {ECO 0000269|PubMed 9148912, ECO 0000269|PubMed 9865945}. # SUPFAM SSF47413 SSF47413 # SUPFAM SSF53822 SSF53822 # TIGRFAMs TIGR02405 trehalos_R_Ecol # eggNOG COG1609 LUCA # eggNOG ENOG4105D4X Bacteria BLAST swissprot:TRER_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRER_ECOLI BioCyc ECOL316407:JW4200-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4200-MONOMER BioCyc EcoCyc:EG12202-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12202-MONOMER COG COG1609 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1609 DIP DIP-11026N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11026N DOI 10.1002/pro.5560071204 http://dx.doi.org/10.1002/pro.5560071204 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.272.20.13026 http://dx.doi.org/10.1074/jbc.272.20.13026 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U06195 http://www.ebi.ac.uk/ena/data/view/U06195 EMBL U07790 http://www.ebi.ac.uk/ena/data/view/U07790 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2118 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2118 EcoGene EG12202 http://www.ecogene.org/geneInfo.php?eg_id=EG12202 EnsemblBacteria AAC77198 http://www.ensemblgenomes.org/id/AAC77198 EnsemblBacteria AAC77198 http://www.ensemblgenomes.org/id/AAC77198 EnsemblBacteria BAE78240 http://www.ensemblgenomes.org/id/BAE78240 EnsemblBacteria BAE78240 http://www.ensemblgenomes.org/id/BAE78240 EnsemblBacteria BAE78240 http://www.ensemblgenomes.org/id/BAE78240 EnsemblBacteria b4241 http://www.ensemblgenomes.org/id/b4241 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0005991 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005991 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.260.40 http://www.cathdb.info/version/latest/superfamily/1.10.260.40 GeneID 948760 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948760 HOGENOM HOG000283706 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000283706&db=HOGENOM6 IntAct P36673 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P36673* InterPro IPR000843 http://www.ebi.ac.uk/interpro/entry/IPR000843 InterPro IPR010982 http://www.ebi.ac.uk/interpro/entry/IPR010982 InterPro IPR012771 http://www.ebi.ac.uk/interpro/entry/IPR012771 InterPro IPR028082 http://www.ebi.ac.uk/interpro/entry/IPR028082 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW4200 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4200 KEGG_Gene eco:b4241 http://www.genome.jp/dbget-bin/www_bget?eco:b4241 KEGG_Orthology KO:K03485 http://www.genome.jp/dbget-bin/www_bget?KO:K03485 OMA FGFTGCD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FGFTGCD PDB 4XXH http://www.ebi.ac.uk/pdbe-srv/view/entry/4XXH PDBsum 4XXH http://www.ebi.ac.uk/pdbsum/4XXH PRINTS PR00036 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00036 PROSITE PS00356 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00356 PROSITE PS50932 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50932 PSORT swissprot:TRER_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRER_ECOLI PSORT-B swissprot:TRER_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRER_ECOLI PSORT2 swissprot:TRER_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRER_ECOLI Pfam PF00356 http://pfam.xfam.org/family/PF00356 Phobius swissprot:TRER_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRER_ECOLI PhylomeDB P36673 http://phylomedb.org/?seqid=P36673 ProteinModelPortal P36673 http://www.proteinmodelportal.org/query/uniprot/P36673 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7608078 http://www.ncbi.nlm.nih.gov/pubmed/7608078 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9148912 http://www.ncbi.nlm.nih.gov/pubmed/9148912 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9865945 http://www.ncbi.nlm.nih.gov/pubmed/9865945 RefSeq NP_418662 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418662 RefSeq WP_001181307 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001181307 SMART SM00354 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00354 SMR P36673 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P36673 STRING 511145.b4241 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4241&targetmode=cogs STRING COG1609 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1609&targetmode=cogs SUPFAM SSF47413 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47413 SUPFAM SSF53822 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822 TIGRFAMs TIGR02405 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02405 UniProtKB TRER_ECOLI http://www.uniprot.org/uniprot/TRER_ECOLI UniProtKB-AC P36673 http://www.uniprot.org/uniprot/P36673 charge swissprot:TRER_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRER_ECOLI eggNOG COG1609 http://eggnogapi.embl.de/nog_data/html/tree/COG1609 eggNOG ENOG4105D4X http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D4X epestfind swissprot:TRER_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRER_ECOLI garnier swissprot:TRER_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRER_ECOLI helixturnhelix swissprot:TRER_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRER_ECOLI hmoment swissprot:TRER_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRER_ECOLI iep swissprot:TRER_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRER_ECOLI inforesidue swissprot:TRER_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRER_ECOLI octanol swissprot:TRER_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRER_ECOLI pepcoil swissprot:TRER_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRER_ECOLI pepdigest swissprot:TRER_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRER_ECOLI pepinfo swissprot:TRER_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRER_ECOLI pepnet swissprot:TRER_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRER_ECOLI pepstats swissprot:TRER_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRER_ECOLI pepwheel swissprot:TRER_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRER_ECOLI pepwindow swissprot:TRER_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRER_ECOLI sigcleave swissprot:TRER_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRER_ECOLI ## Database ID URL or Descriptions # AltName GLXK1_ECOLI GK1 # BIOPHYSICOCHEMICAL PROPERTIES GLXK1_ECOLI Kinetic parameters KM=51 uM for glycerate {ECO 0000269|PubMed 4887503, ECO 0000269|PubMed 9772162}; KM=70 uM for glycerate {ECO 0000269|PubMed 4887503, ECO 0000269|PubMed 9772162}; KM=61 uM for ATP {ECO 0000269|PubMed 4887503, ECO 0000269|PubMed 9772162}; pH dependence Optimum pH is 7.3-7.9. {ECO 0000269|PubMed 4887503, ECO 0000269|PubMed 9772162}; # BRENDA 2.7.1.165 2165 # BioGrid 4261538 8 # CATALYTIC ACTIVITY GLXK1_ECOLI ATP + D-glycerate = ADP + 2-phospho-D- glycerate. # CAUTION E.coli has 2 glycerate kinases, GK1 and GK2; it is not clear which gene encodes which enzyme. {ECO 0000305}. # EcoGene EG11175 garK # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0008887 glycerate kinase activity; IEA:InterPro. # GO_function GO:0043798 glycerate 2-kinase activity; IDA:EcoCyc. # GO_process GO:0031388 organic acid phosphorylation; IEA:InterPro. # GO_process GO:0042838 D-glucarate catabolic process; IEP:EcoCyc. # GO_process GO:0046392 galactarate catabolic process; IEP:EcoCyc. # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.90.1510.10 -; 1. # INDUCTION GLXK1_ECOLI In glycerate, glucarate and glycolate-grown cells but not in glucose-grown cells (at protein level). {ECO 0000269|PubMed 4887503, ECO 0000269|PubMed 9772162}. # IntAct P23524 7 # InterPro IPR004381 Glycerate_kinase # InterPro IPR018193 Glyc_kinase_flavodox-like-dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00260 Glycine, serine and threonine metabolism # KEGG_Pathway ko00561 Glycerolipid metabolism # KEGG_Pathway ko00630 Glyoxylate and dicarboxylate metabolism # MISCELLANEOUS GLXK1_ECOLI GK1 has a half-life of 92 minutes while GK2 has a half-life of 11 minutes at 49 degrees Celsius. # Organism GLXK1_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21599 PTHR21599 # PATRIC 32121662 VBIEscCol129921_3217 # PIR JQ0614 JQ0614 # PIRSF PIRSF006078 GlxK # Pfam PF02595 Gly_kinase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLXK1_ECOLI Glycerate 2-kinase # RefSeq NP_417593 NC_000913.3 # RefSeq WP_001300387 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA57927.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA14239.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=BAE77171.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; # SIMILARITY Belongs to the glycerate kinase type-1 family. {ECO 0000305}. # SUPFAM SSF110738 SSF110738 # TIGRFAMs TIGR00045 TIGR00045 # eggNOG COG1929 LUCA # eggNOG ENOG4105BZW Bacteria BLAST swissprot:GLXK1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLXK1_ECOLI BioCyc ECOL316407:JW3093-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3093-MONOMER BioCyc EcoCyc:GKI-MONOMER http://biocyc.org/getid?id=EcoCyc:GKI-MONOMER BioCyc MetaCyc:GKI-MONOMER http://biocyc.org/getid?id=MetaCyc:GKI-MONOMER COG COG1929 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1929 DIP DIP-28063N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-28063N DOI 10.1021/bi981124f http://dx.doi.org/10.1021/bi981124f DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.165 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.165 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D90212 http://www.ebi.ac.uk/ena/data/view/D90212 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 2.7.1.165 http://enzyme.expasy.org/EC/2.7.1.165 EchoBASE EB1162 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1162 EcoGene EG11175 http://www.ecogene.org/geneInfo.php?eg_id=EG11175 EnsemblBacteria AAC76158 http://www.ensemblgenomes.org/id/AAC76158 EnsemblBacteria AAC76158 http://www.ensemblgenomes.org/id/AAC76158 EnsemblBacteria BAE77171 http://www.ensemblgenomes.org/id/BAE77171 EnsemblBacteria BAE77171 http://www.ensemblgenomes.org/id/BAE77171 EnsemblBacteria BAE77171 http://www.ensemblgenomes.org/id/BAE77171 EnsemblBacteria b3124 http://www.ensemblgenomes.org/id/b3124 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008887 GO_function GO:0043798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043798 GO_process GO:0031388 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031388 GO_process GO:0042838 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042838 GO_process GO:0046392 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046392 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.90.1510.10 http://www.cathdb.info/version/latest/superfamily/3.90.1510.10 GeneID 947632 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947632 HOGENOM HOG000089298 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000089298&db=HOGENOM6 InParanoid P23524 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23524 IntAct P23524 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P23524* IntEnz 2.7.1.165 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.165 InterPro IPR004381 http://www.ebi.ac.uk/interpro/entry/IPR004381 InterPro IPR018193 http://www.ebi.ac.uk/interpro/entry/IPR018193 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3093 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3093 KEGG_Gene eco:b3124 http://www.genome.jp/dbget-bin/www_bget?eco:b3124 KEGG_Orthology KO:K00865 http://www.genome.jp/dbget-bin/www_bget?KO:K00865 KEGG_Pathway ko00260 http://www.genome.jp/kegg-bin/show_pathway?ko00260 KEGG_Pathway ko00561 http://www.genome.jp/kegg-bin/show_pathway?ko00561 KEGG_Pathway ko00630 http://www.genome.jp/kegg-bin/show_pathway?ko00630 KEGG_Reaction rn:R01514 http://www.genome.jp/dbget-bin/www_bget?rn:R01514 OMA NDAGTGM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NDAGTGM PANTHER PTHR21599 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21599 PSORT swissprot:GLXK1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLXK1_ECOLI PSORT-B swissprot:GLXK1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLXK1_ECOLI PSORT2 swissprot:GLXK1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLXK1_ECOLI Pfam PF02595 http://pfam.xfam.org/family/PF02595 Phobius swissprot:GLXK1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLXK1_ECOLI PhylomeDB P23524 http://phylomedb.org/?seqid=P23524 ProteinModelPortal P23524 http://www.proteinmodelportal.org/query/uniprot/P23524 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1705543 http://www.ncbi.nlm.nih.gov/pubmed/1705543 PubMed 4887503 http://www.ncbi.nlm.nih.gov/pubmed/4887503 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9772162 http://www.ncbi.nlm.nih.gov/pubmed/9772162 RefSeq NP_417593 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417593 RefSeq WP_001300387 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300387 SMR P23524 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P23524 STRING 511145.b3124 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3124&targetmode=cogs STRING COG1929 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1929&targetmode=cogs SUPFAM SSF110738 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF110738 TIGRFAMs TIGR00045 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00045 UniProtKB GLXK1_ECOLI http://www.uniprot.org/uniprot/GLXK1_ECOLI UniProtKB-AC P23524 http://www.uniprot.org/uniprot/P23524 charge swissprot:GLXK1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLXK1_ECOLI eggNOG COG1929 http://eggnogapi.embl.de/nog_data/html/tree/COG1929 eggNOG ENOG4105BZW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZW epestfind swissprot:GLXK1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLXK1_ECOLI garnier swissprot:GLXK1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLXK1_ECOLI helixturnhelix swissprot:GLXK1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLXK1_ECOLI hmoment swissprot:GLXK1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLXK1_ECOLI iep swissprot:GLXK1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLXK1_ECOLI inforesidue swissprot:GLXK1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLXK1_ECOLI octanol swissprot:GLXK1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLXK1_ECOLI pepcoil swissprot:GLXK1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLXK1_ECOLI pepdigest swissprot:GLXK1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLXK1_ECOLI pepinfo swissprot:GLXK1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLXK1_ECOLI pepnet swissprot:GLXK1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLXK1_ECOLI pepstats swissprot:GLXK1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLXK1_ECOLI pepwheel swissprot:GLXK1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLXK1_ECOLI pepwindow swissprot:GLXK1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLXK1_ECOLI sigcleave swissprot:GLXK1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLXK1_ECOLI ## Database ID URL or Descriptions # AltName TDP-fucosamine acetyltransferase {ECO:0000255|HAMAP-Rule MF_02027} # AltName dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase {ECO:0000255|HAMAP-Rule MF_02027} # BioGrid 4261646 249 # CATALYTIC ACTIVITY Acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D- galactose = CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose. {ECO:0000255|HAMAP-Rule MF_02027}. # EcoGene EG11455 wecD # FUNCTION WECD_ECOLI Catalyzes the acetylation of dTDP-fucosamine (dTDP-4- amino-4,6-dideoxy-D-galactose) to dTDP-Fuc4NAc, which is utilized in the biosynthesis of the enterobacterial common antigen (ECA). {ECO 0000255|HAMAP-Rule MF_02027}. # GO_function GO:0008080 N-acetyltransferase activity; IDA:EcoCyc. # GO_process GO:0009246 enterobacterial common antigen biosynthetic process; IDA:EcoCyc. # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.630.30 -; 1. # HAMAP MF_02027 WecD_RffC # InterPro IPR000182 GNAT_dom # InterPro IPR002110 Ankyrin_rpt # InterPro IPR012752 AcTrfase_WecD # InterPro IPR016181 Acyl_CoA_acyltransferase # InterPro IPR020683 Ankyrin_rpt-contain_dom # KEGG_Brite ko01000 Enzymes # Organism WECD_ECOLI Escherichia coli (strain K12) # PATHWAY Bacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis. {ECO:0000255|HAMAP-Rule MF_02027}. # PATRIC 32123073 VBIEscCol129921_3906 # PIR A65183 A65183 # PROSITE PS51186 GNAT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName dTDP-fucosamine acetyltransferase {ECO:0000255|HAMAP-Rule MF_02027} # RefSeq WP_001145183 NZ_LN832404.1 # RefSeq YP_026256 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA67590.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAE77508.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the WecD family. {ECO:0000255|HAMAP- Rule MF_02027}. # SIMILARITY Contains 1 N-acetyltransferase domain. {ECO:0000255|HAMAP-Rule MF_02027}. # SUBUNIT Homodimer. {ECO:0000255|HAMAP-Rule MF_02027}. # SUPFAM SSF55729 SSF55729 # TIGRFAMs TIGR02382 wecD_rffC # eggNOG COG0454 LUCA # eggNOG ENOG4108WJ1 Bacteria BLAST swissprot:WECD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:WECD_ECOLI BioCyc ECOL316407:JW5597-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5597-MONOMER BioCyc EcoCyc:TDPFUCACTRANS-MONOMER http://biocyc.org/getid?id=EcoCyc:TDPFUCACTRANS-MONOMER BioCyc MetaCyc:TDPFUCACTRANS-MONOMER http://biocyc.org/getid?id=MetaCyc:TDPFUCACTRANS-MONOMER COG COG0454 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0454 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.210 {ECO:0000255|HAMAP-Rule:MF_02027} http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.210 {ECO:0000255|HAMAP-Rule:MF_02027} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.3.1.210 {ECO:0000255|HAMAP-Rule:MF_02027} http://enzyme.expasy.org/EC/2.3.1.210 {ECO:0000255|HAMAP-Rule:MF_02027} EchoBASE EB1424 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1424 EcoGene EG11455 http://www.ecogene.org/geneInfo.php?eg_id=EG11455 EnsemblBacteria AAT48214 http://www.ensemblgenomes.org/id/AAT48214 EnsemblBacteria AAT48214 http://www.ensemblgenomes.org/id/AAT48214 EnsemblBacteria BAE77508 http://www.ensemblgenomes.org/id/BAE77508 EnsemblBacteria BAE77508 http://www.ensemblgenomes.org/id/BAE77508 EnsemblBacteria BAE77508 http://www.ensemblgenomes.org/id/BAE77508 EnsemblBacteria b3790 http://www.ensemblgenomes.org/id/b3790 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008080 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008080 GO_process GO:0009246 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009246 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.630.30 http://www.cathdb.info/version/latest/superfamily/3.40.630.30 GeneID 948298 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948298 HAMAP MF_02027 http://hamap.expasy.org/unirule/MF_02027 HOGENOM HOG000126448 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126448&db=HOGENOM6 IntEnz 2.3.1.210 {ECO:0000255|HAMAP-Rule:MF_02027} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.210 {ECO:0000255|HAMAP-Rule:MF_02027} InterPro IPR000182 http://www.ebi.ac.uk/interpro/entry/IPR000182 InterPro IPR002110 http://www.ebi.ac.uk/interpro/entry/IPR002110 InterPro IPR012752 http://www.ebi.ac.uk/interpro/entry/IPR012752 InterPro IPR016181 http://www.ebi.ac.uk/interpro/entry/IPR016181 InterPro IPR020683 http://www.ebi.ac.uk/interpro/entry/IPR020683 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5597 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5597 KEGG_Gene eco:b3790 http://www.genome.jp/dbget-bin/www_bget?eco:b3790 KEGG_Orthology KO:K16704 http://www.genome.jp/dbget-bin/www_bget?KO:K16704 OMA TAYWFYR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TAYWFYR PROSITE PS51186 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51186 PSORT swissprot:WECD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:WECD_ECOLI PSORT-B swissprot:WECD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:WECD_ECOLI PSORT2 swissprot:WECD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:WECD_ECOLI Phobius swissprot:WECD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:WECD_ECOLI ProteinModelPortal P27832 http://www.proteinmodelportal.org/query/uniprot/P27832 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8366065 http://www.ncbi.nlm.nih.gov/pubmed/8366065 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001145183 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001145183 RefSeq YP_026256 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026256 SMR P27832 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P27832 STRING 511145.b3790 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3790&targetmode=cogs STRING COG0454 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0454&targetmode=cogs SUPFAM SSF55729 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55729 TIGRFAMs TIGR02382 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02382 UniProtKB WECD_ECOLI http://www.uniprot.org/uniprot/WECD_ECOLI UniProtKB-AC P27832 http://www.uniprot.org/uniprot/P27832 charge swissprot:WECD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:WECD_ECOLI eggNOG COG0454 http://eggnogapi.embl.de/nog_data/html/tree/COG0454 eggNOG ENOG4108WJ1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108WJ1 epestfind swissprot:WECD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:WECD_ECOLI garnier swissprot:WECD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:WECD_ECOLI helixturnhelix swissprot:WECD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:WECD_ECOLI hmoment swissprot:WECD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:WECD_ECOLI iep swissprot:WECD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:WECD_ECOLI inforesidue swissprot:WECD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:WECD_ECOLI octanol swissprot:WECD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:WECD_ECOLI pepcoil swissprot:WECD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:WECD_ECOLI pepdigest swissprot:WECD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:WECD_ECOLI pepinfo swissprot:WECD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:WECD_ECOLI pepnet swissprot:WECD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:WECD_ECOLI pepstats swissprot:WECD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:WECD_ECOLI pepwheel swissprot:WECD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:WECD_ECOLI pepwindow swissprot:WECD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:WECD_ECOLI sigcleave swissprot:WECD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:WECD_ECOLI ## Database ID URL or Descriptions # AltName EIICB-Mtl {ECO:0000250|UniProtKB P28008} # AltName PTS system mannitol-specific EIIB component {ECO:0000250|UniProtKB P28008} # AltName PTS system mannitol-specific EIIC component {ECO:0000250|UniProtKB P28008} # AltName PTS system mannitol-specific EIIC component {ECO:0000250|UniProtKB P28008} # BioGrid 4262068 76 # CATALYTIC ACTIVITY [Protein]-N(pi)-phospho-L-histidine + D- mannitol(Side 1) = [protein]-L-histidine + D-mannitol 1- phosphate(Side 2). {ECO:0000250|UniProtKB P00550}. # CDD cd05567 PTS_IIB_mannitol # DOMAIN PTMCB_ECOLI The EIIC type-2 domain forms the PTS system translocation channel and contains the specific substrate-binding site. {ECO 0000255|PROSITE-ProRule PRU00427}. # DOMAIN PTMCB_ECOLI The PTS EIIB type-2 domain is phosphorylated by phospho- EIIA on a cysteinyl residue. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the PTS EIIC type-2 domain. {ECO 0000255|PROSITE- ProRule PRU00422}. # EcoGene EG11792 cmtA # FUNCTION PTMCB_ECOLI The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CmtAB PTS system is involved in D-mannitol transport. {ECO 0000250|UniProtKB P28008}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0016301 kinase activity; IEA:UniProtKB-KW. # GO_function GO:0022872 protein-N(PI)-phosphohistidine-mannitol phosphotransferase system transmembrane transporter activity; IEA:InterPro. # GO_function GO:0090563 protein-phosphocysteine-sugar phosphotransferase activity; IBA:GO_Central. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; ISA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # Gene3D 3.40.50.10370 -; 1. # IntAct P69826 3 # InterPro IPR003352 PTS_EIIC # InterPro IPR003501 PTS_EIIB_2/3 # InterPro IPR004718 PTS_IIC_mtl # InterPro IPR013011 PTS_EIIB_2 # InterPro IPR013014 PTS_EIIC_2 # InterPro IPR029503 PTS_EIIB_mannitol # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00274 PTS system, mannitol-specific II component # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko00051 Fructose and mannose metabolism # KEGG_Pathway ko02060 Phosphotransferase system (PTS) # Organism PTMCB_ECOLI Escherichia coli (strain K12) # PATRIC 32121278 VBIEscCol129921_3027 # PIR D65078 S36123 # PROSITE PS51099 PTS_EIIB_TYPE_2 # PROSITE PS51104 PTS_EIIC_TYPE_2 # Pfam PF02302 PTS_IIB # Pfam PF02378 PTS_EIIC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Mannitol permease IIC component {ECO:0000250|UniProtKB P28008} # RecName Mannitol-specific phosphotransferase enzyme IIB component {ECO:0000250|UniProtKB P28008} # RecName PTS system mannitol-specific cryptic EIICB component {ECO:0000303|PubMed 8353127} # RefSeq NP_417408 NC_000913.3 # RefSeq WP_000428805 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA51229.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Vector contamination at the C-terminus.; Evidence={ECO 0000305}; # SIMILARITY Contains 1 PTS EIIB type-2 domain. {ECO:0000255|PROSITE-ProRule PRU00422}. # SIMILARITY Contains 1 PTS EIIC type-2 domain. {ECO:0000255|PROSITE-ProRule PRU00427}. # SUBCELLULAR LOCATION PTMCB_ECOLI Cell inner membrane {ECO 0000255|PROSITE- ProRule PRU00427, ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00427, ECO 0000269|PubMed 15919996}. # SUPFAM SSF52794 SSF52794 # TCDB 4.A.2.1.24 the pts fructose-mannitol (fru) family # TIGRFAMs TIGR00851 mtlA # eggNOG COG2213 LUCA # eggNOG ENOG4105CTS Bacteria BLAST swissprot:PTMCB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTMCB_ECOLI BioCyc ECOL316407:JW2900-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2900-MONOMER BioCyc EcoCyc:CMTA-MONOMER http://biocyc.org/getid?id=EcoCyc:CMTA-MONOMER BioCyc MetaCyc:CMTA-MONOMER http://biocyc.org/getid?id=MetaCyc:CMTA-MONOMER COG COG2213 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2213 DOI 10.1016/0304-4165(93)90103-F http://dx.doi.org/10.1016/0304-4165(93)90103-F DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.197 {ECO:0000250|UniProtKB:P00550, ECO:0000250|UniProtKB:P28008} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.197 {ECO:0000250|UniProtKB:P00550, ECO:0000250|UniProtKB:P28008} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EMBL X72677 http://www.ebi.ac.uk/ena/data/view/X72677 ENZYME 2.7.1.197 {ECO:0000250|UniProtKB:P00550, ECO:0000250|UniProtKB:P28008} http://enzyme.expasy.org/EC/2.7.1.197 {ECO:0000250|UniProtKB:P00550, ECO:0000250|UniProtKB:P28008} EchoBASE EB1740 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1740 EcoGene EG11792 http://www.ecogene.org/geneInfo.php?eg_id=EG11792 EnsemblBacteria AAC75970 http://www.ensemblgenomes.org/id/AAC75970 EnsemblBacteria AAC75970 http://www.ensemblgenomes.org/id/AAC75970 EnsemblBacteria BAE76996 http://www.ensemblgenomes.org/id/BAE76996 EnsemblBacteria BAE76996 http://www.ensemblgenomes.org/id/BAE76996 EnsemblBacteria BAE76996 http://www.ensemblgenomes.org/id/BAE76996 EnsemblBacteria b2933 http://www.ensemblgenomes.org/id/b2933 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_function GO:0022872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022872 GO_function GO:0090563 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090563 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.40.50.10370 http://www.cathdb.info/version/latest/superfamily/3.40.50.10370 GeneID 945256 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945256 HOGENOM HOG000252814 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000252814&db=HOGENOM6 IntAct P69826 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69826* IntEnz 2.7.1.197 {ECO:0000250|UniProtKB:P00550, ECO:0000250|UniProtKB:P28008} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.197 {ECO:0000250|UniProtKB:P00550, ECO:0000250|UniProtKB:P28008} InterPro IPR003352 http://www.ebi.ac.uk/interpro/entry/IPR003352 InterPro IPR003501 http://www.ebi.ac.uk/interpro/entry/IPR003501 InterPro IPR004718 http://www.ebi.ac.uk/interpro/entry/IPR004718 InterPro IPR013011 http://www.ebi.ac.uk/interpro/entry/IPR013011 InterPro IPR013014 http://www.ebi.ac.uk/interpro/entry/IPR013014 InterPro IPR029503 http://www.ebi.ac.uk/interpro/entry/IPR029503 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2900 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2900 KEGG_Gene eco:b2933 http://www.genome.jp/dbget-bin/www_bget?eco:b2933 KEGG_Orthology KO:K02800 http://www.genome.jp/dbget-bin/www_bget?KO:K02800 KEGG_Pathway ko00051 http://www.genome.jp/kegg-bin/show_pathway?ko00051 KEGG_Pathway ko02060 http://www.genome.jp/kegg-bin/show_pathway?ko02060 KEGG_Reaction rn:R02704 http://www.genome.jp/dbget-bin/www_bget?rn:R02704 OMA DIVVTHE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DIVVTHE PROSITE PS51099 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51099 PROSITE PS51104 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51104 PSORT swissprot:PTMCB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTMCB_ECOLI PSORT-B swissprot:PTMCB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTMCB_ECOLI PSORT2 swissprot:PTMCB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTMCB_ECOLI Pfam PF02302 http://pfam.xfam.org/family/PF02302 Pfam PF02378 http://pfam.xfam.org/family/PF02378 Phobius swissprot:PTMCB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTMCB_ECOLI PhylomeDB P69826 http://phylomedb.org/?seqid=P69826 ProteinModelPortal P69826 http://www.proteinmodelportal.org/query/uniprot/P69826 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8353127 http://www.ncbi.nlm.nih.gov/pubmed/8353127 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417408 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417408 RefSeq WP_000428805 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000428805 SMR P69826 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69826 STRING 511145.b2933 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2933&targetmode=cogs STRING COG2213 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2213&targetmode=cogs SUPFAM SSF52794 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52794 TCDB 4.A.2.1.24 http://www.tcdb.org/search/result.php?tc=4.A.2.1.24 TIGRFAMs TIGR00851 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00851 UniProtKB PTMCB_ECOLI http://www.uniprot.org/uniprot/PTMCB_ECOLI UniProtKB-AC P69826 http://www.uniprot.org/uniprot/P69826 charge swissprot:PTMCB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTMCB_ECOLI eggNOG COG2213 http://eggnogapi.embl.de/nog_data/html/tree/COG2213 eggNOG ENOG4105CTS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CTS epestfind swissprot:PTMCB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTMCB_ECOLI garnier swissprot:PTMCB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTMCB_ECOLI helixturnhelix swissprot:PTMCB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTMCB_ECOLI hmoment swissprot:PTMCB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTMCB_ECOLI iep swissprot:PTMCB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTMCB_ECOLI inforesidue swissprot:PTMCB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTMCB_ECOLI octanol swissprot:PTMCB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTMCB_ECOLI pepcoil swissprot:PTMCB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTMCB_ECOLI pepdigest swissprot:PTMCB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTMCB_ECOLI pepinfo swissprot:PTMCB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTMCB_ECOLI pepnet swissprot:PTMCB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTMCB_ECOLI pepstats swissprot:PTMCB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTMCB_ECOLI pepwheel swissprot:PTMCB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTMCB_ECOLI pepwindow swissprot:PTMCB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTMCB_ECOLI sigcleave swissprot:PTMCB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTMCB_ECOLI ## Database ID URL or Descriptions # BioGrid 4259760 77 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG11772 yafF # Organism YAFF_ECOLI Escherichia coli (strain K12) # PATRIC 48659629 VBIEscCol107702_0212 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAFF_ECOLI Putative uncharacterized protein YafF # eggNOG COG5433 LUCA # eggNOG ENOG410600T Bacteria BLAST swissprot:YAFF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAFF_ECOLI BioCyc ECOL316407:JW0208-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0208-MONOMER BioCyc EcoCyc:MONOMER0-2653 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2653 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG11772 http://www.ecogene.org/geneInfo.php?eg_id=EG11772 EnsemblBacteria BAA77888 http://www.ensemblgenomes.org/id/BAA77888 EnsemblBacteria BAA77888 http://www.ensemblgenomes.org/id/BAA77888 EnsemblBacteria BAA77888 http://www.ensemblgenomes.org/id/BAA77888 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv KEGG_Gene ecj:JW0208 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0208 OMA NCAMDEN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NCAMDEN PSORT swissprot:YAFF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAFF_ECOLI PSORT-B swissprot:YAFF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAFF_ECOLI PSORT2 swissprot:YAFF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAFF_ECOLI Phobius swissprot:YAFF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAFF_ECOLI ProteinModelPortal Q2EEP9 http://www.proteinmodelportal.org/query/uniprot/Q2EEP9 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 STRING 511145.b3484 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3484&targetmode=cogs UniProtKB YAFF_ECOLI http://www.uniprot.org/uniprot/YAFF_ECOLI UniProtKB-AC Q2EEP9 http://www.uniprot.org/uniprot/Q2EEP9 charge swissprot:YAFF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAFF_ECOLI eggNOG COG5433 http://eggnogapi.embl.de/nog_data/html/tree/COG5433 eggNOG ENOG410600T http://eggnogapi.embl.de/nog_data/html/tree/ENOG410600T epestfind swissprot:YAFF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAFF_ECOLI garnier swissprot:YAFF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAFF_ECOLI helixturnhelix swissprot:YAFF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAFF_ECOLI hmoment swissprot:YAFF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAFF_ECOLI iep swissprot:YAFF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAFF_ECOLI inforesidue swissprot:YAFF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAFF_ECOLI octanol swissprot:YAFF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAFF_ECOLI pepcoil swissprot:YAFF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAFF_ECOLI pepdigest swissprot:YAFF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAFF_ECOLI pepinfo swissprot:YAFF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAFF_ECOLI pepnet swissprot:YAFF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAFF_ECOLI pepstats swissprot:YAFF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAFF_ECOLI pepwheel swissprot:YAFF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAFF_ECOLI pepwindow swissprot:YAFF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAFF_ECOLI sigcleave swissprot:YAFF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAFF_ECOLI ## Database ID URL or Descriptions # AltName EX3_ECOLI AP endonuclease VI # BioGrid 4261904 52 # CATALYTIC ACTIVITY EX3_ECOLI Exonucleolytic cleavage in the 3'- to 5'- direction to yield nucleoside 5'-phosphates. # COFACTOR EX3_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000250}; Note=Probably binds two magnesium or manganese ions per subunit. {ECO 0000250}; # EcoGene EG11073 xthA # FUNCTION EX3_ECOLI Major apurinic-apyrimidinic endonuclease of E.coli. It removes the damaged DNA at cytosines and guanines by cleaving on the 3'-side of the AP site by a beta-elimination reaction. It exhibits 3'-5'-exonuclease, 3'-phosphomonoesterase, 3'-repair diesterase and ribonuclease H activities. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_function GO:0004519 endonuclease activity; IEA:InterPro. # GO_function GO:0004527 exonuclease activity; IDA:EcoCyc. # GO_function GO:0008853 exodeoxyribonuclease III activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006281 DNA repair; IEA:UniProtKB-KW. # GO_process GO:0006974 cellular response to DNA damage stimulus; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004518 nuclease activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # Gene3D 3.60.10.10 -; 1. # IntAct P09030 16 # InterPro IPR004808 AP_endonuc_1 # InterPro IPR005135 Endo/exonuclease/phosphatase # InterPro IPR020847 AP_endonuclease_F1_BS # InterPro IPR020848 AP_endonuclease_F1_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko03410 Base excision repair # Organism EX3_ECOLI Escherichia coli (strain K12) # PANTHER PTHR22748 PTHR22748 # PATRIC 32118809 VBIEscCol129921_1822 # PDB 1AKO X-ray; 1.70 A; A=1-268 # PIR E64934 NCECX3 # PROSITE PS00726 AP_NUCLEASE_F1_1 # PROSITE PS00727 AP_NUCLEASE_F1_2 # PROSITE PS00728 AP_NUCLEASE_F1_3 # PROSITE PS51435 AP_NUCLEASE_F1_4 # Pfam PF03372 Exo_endo_phos # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EX3_ECOLI Exodeoxyribonuclease III # RefSeq NP_416263 NC_000913.3 # RefSeq WP_000673918 NZ_LN832404.1 # SIMILARITY Belongs to the DNA repair enzymes AP/ExoA family. {ECO 0000305}. # SUBUNIT EX3_ECOLI Monomer. # SUPFAM SSF56219 SSF56219 # TIGRFAMs TIGR00633 xth # WEB RESOURCE EX3_ECOLI Name=Wikipedia; Note=Exonuclease III entry; URL="https //en.wikipedia.org/wiki/Exonuclease_III"; # eggNOG COG0708 LUCA # eggNOG ENOG4105CGK Bacteria BLAST swissprot:EX3_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EX3_ECOLI BioCyc ECOL316407:JW1738-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1738-MONOMER BioCyc EcoCyc:EG11073-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11073-MONOMER BioCyc MetaCyc:EG11073-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11073-MONOMER COG COG0708 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0708 DIP DIP-11148N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11148N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/374381a0 http://dx.doi.org/10.1038/374381a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/24.22.4572 http://dx.doi.org/10.1093/nar/24.22.4572 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.11.2 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.11.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M22592 http://www.ebi.ac.uk/ena/data/view/M22592 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X13002 http://www.ebi.ac.uk/ena/data/view/X13002 ENZYME 3.1.11.2 http://enzyme.expasy.org/EC/3.1.11.2 EchoBASE EB1066 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1066 EcoGene EG11073 http://www.ecogene.org/geneInfo.php?eg_id=EG11073 EnsemblBacteria AAC74819 http://www.ensemblgenomes.org/id/AAC74819 EnsemblBacteria AAC74819 http://www.ensemblgenomes.org/id/AAC74819 EnsemblBacteria BAA15540 http://www.ensemblgenomes.org/id/BAA15540 EnsemblBacteria BAA15540 http://www.ensemblgenomes.org/id/BAA15540 EnsemblBacteria BAA15540 http://www.ensemblgenomes.org/id/BAA15540 EnsemblBacteria b1749 http://www.ensemblgenomes.org/id/b1749 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004519 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004519 GO_function GO:0004527 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004527 GO_function GO:0008853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008853 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006281 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.60.10.10 http://www.cathdb.info/version/latest/superfamily/3.60.10.10 GeneID 946254 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946254 HOGENOM HOG000034587 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000034587&db=HOGENOM6 InParanoid P09030 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P09030 IntAct P09030 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P09030* IntEnz 3.1.11.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.11.2 InterPro IPR004808 http://www.ebi.ac.uk/interpro/entry/IPR004808 InterPro IPR005135 http://www.ebi.ac.uk/interpro/entry/IPR005135 InterPro IPR020847 http://www.ebi.ac.uk/interpro/entry/IPR020847 InterPro IPR020848 http://www.ebi.ac.uk/interpro/entry/IPR020848 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW1738 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1738 KEGG_Gene eco:b1749 http://www.genome.jp/dbget-bin/www_bget?eco:b1749 KEGG_Orthology KO:K01142 http://www.genome.jp/dbget-bin/www_bget?KO:K01142 KEGG_Pathway ko03410 http://www.genome.jp/kegg-bin/show_pathway?ko03410 MINT MINT-1243969 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1243969 OMA YTPNSQQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YTPNSQQ PANTHER PTHR22748 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22748 PDB 1AKO http://www.ebi.ac.uk/pdbe-srv/view/entry/1AKO PDBsum 1AKO http://www.ebi.ac.uk/pdbsum/1AKO PROSITE PS00726 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00726 PROSITE PS00727 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00727 PROSITE PS00728 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00728 PROSITE PS51435 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51435 PSORT swissprot:EX3_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EX3_ECOLI PSORT-B swissprot:EX3_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EX3_ECOLI PSORT2 swissprot:EX3_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EX3_ECOLI Pfam PF03372 http://pfam.xfam.org/family/PF03372 Phobius swissprot:EX3_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EX3_ECOLI PhylomeDB P09030 http://phylomedb.org/?seqid=P09030 ProteinModelPortal P09030 http://www.proteinmodelportal.org/query/uniprot/P09030 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3049539 http://www.ncbi.nlm.nih.gov/pubmed/3049539 PubMed 7885481 http://www.ncbi.nlm.nih.gov/pubmed/7885481 PubMed 8948651 http://www.ncbi.nlm.nih.gov/pubmed/8948651 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_416263 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416263 RefSeq WP_000673918 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000673918 SMR P09030 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P09030 STRING 511145.b1749 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1749&targetmode=cogs STRING COG0708 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0708&targetmode=cogs SUPFAM SSF56219 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56219 SWISS-2DPAGE P09030 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P09030 TIGRFAMs TIGR00633 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00633 UniProtKB EX3_ECOLI http://www.uniprot.org/uniprot/EX3_ECOLI UniProtKB-AC P09030 http://www.uniprot.org/uniprot/P09030 charge swissprot:EX3_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EX3_ECOLI eggNOG COG0708 http://eggnogapi.embl.de/nog_data/html/tree/COG0708 eggNOG ENOG4105CGK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CGK epestfind swissprot:EX3_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EX3_ECOLI garnier swissprot:EX3_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EX3_ECOLI helixturnhelix swissprot:EX3_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EX3_ECOLI hmoment swissprot:EX3_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EX3_ECOLI iep swissprot:EX3_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EX3_ECOLI inforesidue swissprot:EX3_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EX3_ECOLI octanol swissprot:EX3_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EX3_ECOLI pepcoil swissprot:EX3_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EX3_ECOLI pepdigest swissprot:EX3_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EX3_ECOLI pepinfo swissprot:EX3_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EX3_ECOLI pepnet swissprot:EX3_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EX3_ECOLI pepstats swissprot:EX3_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EX3_ECOLI pepwheel swissprot:EX3_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EX3_ECOLI pepwindow swissprot:EX3_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EX3_ECOLI sigcleave swissprot:EX3_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EX3_ECOLI ## Database ID URL or Descriptions # BioGrid 4261879 12 # EcoGene EG12358 ssuB # FUNCTION SSUB_ECOLI Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import. Responsible for energy coupling to the transport system (Probable). {ECO 0000305|PubMed 10506196, ECO 0000305|PubMed 10781534}. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IEA:UniProtKB-HAMAP. # GO_function GO:0005215 transporter activity; IEA:UniProtKB-HAMAP. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0016887 ATPase activity; IEA:InterPro. # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.300 -; 1. # INDUCTION Repressed by sulfate and cystine. Transcriptionally regulated by cbl. {ECO:0000269|PubMed 10506196}. # IntAct P0AAI1 7 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR017871 ABC_transporter_CS # InterPro IPR017875 SsuB # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00436 Sulfonate transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism SSUB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR24220:SF365 PTHR24220:SF365 # PATRIC 32117085 VBIEscCol129921_0967 # PIR D64833 D64833 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # PROSITE PS51291 SSUB # Pfam PF00005 ABC_tran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Aliphatic sulfonates import ATP-binding protein SsuB {ECO:0000255|HAMAP-Rule MF_01724} # RefSeq NP_415453 NC_000913.3 # RefSeq WP_001090506 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. Aliphatic sulfonates importer (TC 3.A.1.17.2) family. {ECO:0000255|HAMAP- Rule MF_01724}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|HAMAP- Rule MF_01724}. # SMART SM00382 AAA # SUBCELLULAR LOCATION SSUB_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01724}; Peripheral membrane protein {ECO 0000255|HAMAP- Rule MF_01724}. # SUBUNIT The complex is composed of two ATP-binding proteins (SsuB), two transmembrane proteins (SsuC) and a solute-binding protein (SsuA). {ECO:0000255|HAMAP-Rule MF_01724}. # SUPFAM SSF52540 SSF52540 # eggNOG COG1116 LUCA # eggNOG ENOG4105E2Y Bacteria BLAST swissprot:SSUB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SSUB_ECOLI BioCyc ECOL316407:JW0916-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0916-MONOMER BioCyc EcoCyc:YCBE-MONOMER http://biocyc.org/getid?id=EcoCyc:YCBE-MONOMER BioCyc MetaCyc:YCBE-MONOMER http://biocyc.org/getid?id=MetaCyc:YCBE-MONOMER COG COG1116 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1116 DOI 10.1007/s002030100298 http://dx.doi.org/10.1007/s002030100298 DOI 10.1016/0378-1119(86)90360-4 http://dx.doi.org/10.1016/0378-1119(86)90360-4 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.274.41.29358 http://dx.doi.org/10.1074/jbc.274.41.29358 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.10.2687-2695.2000 http://dx.doi.org/10.1128/JB.182.10.2687-2695.2000 EC_number EC:3.6.3.- {ECO:0000255|HAMAP-Rule:MF_01724} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.- {ECO:0000255|HAMAP-Rule:MF_01724} EMBL AJ237695 http://www.ebi.ac.uk/ena/data/view/AJ237695 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M15273 http://www.ebi.ac.uk/ena/data/view/M15273 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.6.3.- {ECO:0000255|HAMAP-Rule:MF_01724} http://enzyme.expasy.org/EC/3.6.3.- {ECO:0000255|HAMAP-Rule:MF_01724} EchoBASE EB2261 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2261 EcoGene EG12358 http://www.ecogene.org/geneInfo.php?eg_id=EG12358 EnsemblBacteria AAC74019 http://www.ensemblgenomes.org/id/AAC74019 EnsemblBacteria AAC74019 http://www.ensemblgenomes.org/id/AAC74019 EnsemblBacteria BAA35685 http://www.ensemblgenomes.org/id/BAA35685 EnsemblBacteria BAA35685 http://www.ensemblgenomes.org/id/BAA35685 EnsemblBacteria BAA35685 http://www.ensemblgenomes.org/id/BAA35685 EnsemblBacteria b0933 http://www.ensemblgenomes.org/id/b0933 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947220 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947220 InParanoid P0AAI1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAI1 IntAct P0AAI1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAI1* IntEnz 3.6.3.- {ECO:0000255|HAMAP-Rule:MF_01724} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.- {ECO:0000255|HAMAP-Rule:MF_01724} InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR017875 http://www.ebi.ac.uk/interpro/entry/IPR017875 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0916 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0916 KEGG_Gene eco:b0933 http://www.genome.jp/dbget-bin/www_bget?eco:b0933 KEGG_Orthology KO:K15555 http://www.genome.jp/dbget-bin/www_bget?KO:K15555 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA TRIEMQS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TRIEMQS PANTHER PTHR24220:SF365 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24220:SF365 PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PROSITE PS51291 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51291 PSORT swissprot:SSUB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SSUB_ECOLI PSORT-B swissprot:SSUB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SSUB_ECOLI PSORT2 swissprot:SSUB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SSUB_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Phobius swissprot:SSUB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SSUB_ECOLI PhylomeDB P0AAI1 http://phylomedb.org/?seqid=P0AAI1 ProteinModelPortal P0AAI1 http://www.proteinmodelportal.org/query/uniprot/P0AAI1 PubMed 10506196 http://www.ncbi.nlm.nih.gov/pubmed/10506196 PubMed 10781534 http://www.ncbi.nlm.nih.gov/pubmed/10781534 PubMed 11479697 http://www.ncbi.nlm.nih.gov/pubmed/11479697 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3549459 http://www.ncbi.nlm.nih.gov/pubmed/3549459 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415453 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415453 RefSeq WP_001090506 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001090506 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 STRING 511145.b0933 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0933&targetmode=cogs STRING COG1116 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1116&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB SSUB_ECOLI http://www.uniprot.org/uniprot/SSUB_ECOLI UniProtKB-AC P0AAI1 http://www.uniprot.org/uniprot/P0AAI1 charge swissprot:SSUB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SSUB_ECOLI eggNOG COG1116 http://eggnogapi.embl.de/nog_data/html/tree/COG1116 eggNOG ENOG4105E2Y http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E2Y epestfind swissprot:SSUB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SSUB_ECOLI garnier swissprot:SSUB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SSUB_ECOLI helixturnhelix swissprot:SSUB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SSUB_ECOLI hmoment swissprot:SSUB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SSUB_ECOLI iep swissprot:SSUB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SSUB_ECOLI inforesidue swissprot:SSUB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SSUB_ECOLI octanol swissprot:SSUB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SSUB_ECOLI pepcoil swissprot:SSUB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SSUB_ECOLI pepdigest swissprot:SSUB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SSUB_ECOLI pepinfo swissprot:SSUB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SSUB_ECOLI pepnet swissprot:SSUB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SSUB_ECOLI pepstats swissprot:SSUB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SSUB_ECOLI pepwheel swissprot:SSUB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SSUB_ECOLI pepwindow swissprot:SSUB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SSUB_ECOLI sigcleave swissprot:SSUB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SSUB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260556 101 # CDD cd06174 MFS # DISRUPTION PHENOTYPE Mutants are more sensitive to nalidixic acid, mitomycin C and other stresses such as hydrogen peroxide or UV irradiation. {ECO:0000269|PubMed 20128927}. # EcoGene EG13283 emrY # FUNCTION EMRY_ECOLI Part of the tripartite efflux system EmrYK-TolC, which confers resistance to various drugs. {ECO 0000250}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006974 cellular response to DNA damage stimulus; IMP:EcoCyc. # GO_process GO:0046677 response to antibiotic; IMP:EcoCyc. # GO_process GO:0055085 transmembrane transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0055085 transmembrane transport # INDUCTION Growth phase-dependent transcription is induced by tetracycline. Expression may be controlled by both RpoS and the Mar system. {ECO:0000269|PubMed 12501312}. # IntAct P52600 2 # InterPro IPR004638 Drug-R_transpt_efflux_EmrB # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02020 Two-component system # Organism EMRY_ECOLI Escherichia coli (strain K12) # PATRIC 32120113 VBIEscCol129921_2465 # PIR D65010 D65010 # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EMRY_ECOLI Probable multidrug resistance protein EmrY # RefSeq NP_416868 NC_000913.3 # RefSeq WP_001018714 NZ_CP014272.1 # SIMILARITY Belongs to the major facilitator superfamily. EmrB family. {ECO 0000305}. # SUBCELLULAR LOCATION EMRY_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # SUBUNIT Part of the tripartite efflux system EmrYK-TolC, which is composed of an inner membrane transporter, EmrY, a membrane fusion protein, EmrK, and an outer membrane component, TolC. The complex forms a large protein conduit and can translocate molecules across both the inner and outer membranes (By similarity). {ECO 0000250}. # SUPFAM SSF103473 SSF103473; 3 # TIGRFAMs TIGR00711 efflux_EmrB # eggNOG ENOG4105C0R Bacteria # eggNOG ENOG410XNN3 LUCA BLAST swissprot:EMRY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EMRY_ECOLI BioCyc ECOL316407:JW2364-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2364-MONOMER BioCyc EcoCyc:EMRY-MONOMER http://biocyc.org/getid?id=EcoCyc:EMRY-MONOMER COG COG0477 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0477 DIP DIP-9507N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9507N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1186/1471-2180-10-35 http://dx.doi.org/10.1186/1471-2180-10-35 DOI 10.2323/jgam.43.257 http://dx.doi.org/10.2323/jgam.43.257 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D78168 http://www.ebi.ac.uk/ena/data/view/D78168 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3068 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3068 EcoGene EG13283 http://www.ecogene.org/geneInfo.php?eg_id=EG13283 EnsemblBacteria AAC75426 http://www.ensemblgenomes.org/id/AAC75426 EnsemblBacteria AAC75426 http://www.ensemblgenomes.org/id/AAC75426 EnsemblBacteria BAA16230 http://www.ensemblgenomes.org/id/BAA16230 EnsemblBacteria BAA16230 http://www.ensemblgenomes.org/id/BAA16230 EnsemblBacteria BAA16230 http://www.ensemblgenomes.org/id/BAA16230 EnsemblBacteria b2367 http://www.ensemblgenomes.org/id/b2367 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 946835 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946835 HOGENOM HOG000112190 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000112190&db=HOGENOM6 InParanoid P52600 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P52600 IntAct P52600 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P52600* InterPro IPR004638 http://www.ebi.ac.uk/interpro/entry/IPR004638 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2364 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2364 KEGG_Gene eco:b2367 http://www.genome.jp/dbget-bin/www_bget?eco:b2367 KEGG_Orthology KO:K07786 http://www.genome.jp/dbget-bin/www_bget?KO:K07786 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 MINT MINT-1286081 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1286081 OMA ADNFPPN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ADNFPPN PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:EMRY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EMRY_ECOLI PSORT-B swissprot:EMRY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EMRY_ECOLI PSORT2 swissprot:EMRY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EMRY_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:EMRY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EMRY_ECOLI PhylomeDB P52600 http://phylomedb.org/?seqid=P52600 ProteinModelPortal P52600 http://www.proteinmodelportal.org/query/uniprot/P52600 PubMed 12501312 http://www.ncbi.nlm.nih.gov/pubmed/12501312 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20128927 http://www.ncbi.nlm.nih.gov/pubmed/20128927 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416868 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416868 RefSeq WP_001018714 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001018714 STRING 511145.b2367 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2367&targetmode=cogs STRING COG0477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0477&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TIGRFAMs TIGR00711 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00711 UniProtKB EMRY_ECOLI http://www.uniprot.org/uniprot/EMRY_ECOLI UniProtKB-AC P52600 http://www.uniprot.org/uniprot/P52600 charge swissprot:EMRY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EMRY_ECOLI eggNOG ENOG4105C0R http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C0R eggNOG ENOG410XNN3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNN3 epestfind swissprot:EMRY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EMRY_ECOLI garnier swissprot:EMRY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EMRY_ECOLI helixturnhelix swissprot:EMRY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EMRY_ECOLI hmoment swissprot:EMRY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EMRY_ECOLI iep swissprot:EMRY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EMRY_ECOLI inforesidue swissprot:EMRY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EMRY_ECOLI octanol swissprot:EMRY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EMRY_ECOLI pepcoil swissprot:EMRY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EMRY_ECOLI pepdigest swissprot:EMRY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EMRY_ECOLI pepinfo swissprot:EMRY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EMRY_ECOLI pepnet swissprot:EMRY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EMRY_ECOLI pepstats swissprot:EMRY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EMRY_ECOLI pepwheel swissprot:EMRY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EMRY_ECOLI pepwindow swissprot:EMRY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EMRY_ECOLI sigcleave swissprot:EMRY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EMRY_ECOLI ## Database ID URL or Descriptions # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # InterPro IPR020263 Uncharacterised_YqgD # Organism YQGD_ECOLI Escherichia coli (strain K12) # PATRIC 48665320 VBIEscCol107702_2970 # PIR D65079 D65079 # Pfam PF10885 DUF2684 # ProDom PD060540 Uncharacterised_YqgD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQGD_ECOLI Uncharacterized protein YqgD # RefSeq WP_001326496 NZ_LN832404.1 BLAST swissprot:YQGD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQGD_ECOLI BioCyc ECOL316407:JW2908-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2908-MONOMER BioCyc EcoCyc:G7523-MONOMER http://biocyc.org/getid?id=EcoCyc:G7523-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2958 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2958 EnsemblBacteria BAE77004 http://www.ensemblgenomes.org/id/BAE77004 EnsemblBacteria BAE77004 http://www.ensemblgenomes.org/id/BAE77004 EnsemblBacteria BAE77004 http://www.ensemblgenomes.org/id/BAE77004 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv InterPro IPR020263 http://www.ebi.ac.uk/interpro/entry/IPR020263 KEGG_Gene ecj:JW2908 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2908 OMA LRIYILQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LRIYILQ PSORT swissprot:YQGD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQGD_ECOLI PSORT-B swissprot:YQGD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQGD_ECOLI PSORT2 swissprot:YQGD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQGD_ECOLI Pfam PF10885 http://pfam.xfam.org/family/PF10885 Phobius swissprot:YQGD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQGD_ECOLI ProteinModelPortal P46879 http://www.proteinmodelportal.org/query/uniprot/P46879 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001326496 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001326496 UniProtKB YQGD_ECOLI http://www.uniprot.org/uniprot/YQGD_ECOLI UniProtKB-AC P46879 http://www.uniprot.org/uniprot/P46879 charge swissprot:YQGD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQGD_ECOLI epestfind swissprot:YQGD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQGD_ECOLI garnier swissprot:YQGD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQGD_ECOLI helixturnhelix swissprot:YQGD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQGD_ECOLI hmoment swissprot:YQGD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQGD_ECOLI iep swissprot:YQGD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQGD_ECOLI inforesidue swissprot:YQGD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQGD_ECOLI octanol swissprot:YQGD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQGD_ECOLI pepcoil swissprot:YQGD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQGD_ECOLI pepdigest swissprot:YQGD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQGD_ECOLI pepinfo swissprot:YQGD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQGD_ECOLI pepnet swissprot:YQGD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQGD_ECOLI pepstats swissprot:YQGD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQGD_ECOLI pepwheel swissprot:YQGD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQGD_ECOLI pepwindow swissprot:YQGD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQGD_ECOLI sigcleave swissprot:YQGD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQGD_ECOLI ## Database ID URL or Descriptions # BioGrid 4260065 16 # EcoGene EG11489 csgA # FUNCTION CSGA_ECOLI Curlin is the structural subunit of the curli fimbriae. Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. # GO_component GO:0009289 pilus; IDA:EcoCyc. # GO_process GO:0007155 cell adhesion; IMP:EcoCyc. # GO_process GO:0044010 single-species biofilm formation; IMP:EcoCyc. # GO_process GO:1990000 amyloid fibril formation; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0007155 cell adhesion # GOslim_process GO:0008150 biological_process # GOslim_process GO:0030198 extracellular matrix organization # INDUCTION Under control of the CsgD transcription factor, part of the csgBAC/ymdA operon. {ECO:0000269|PubMed 17010156}. # InterPro IPR009742 Curlin_rpt # KEGG_Brite ko02044 Secretion system # Organism CSGA_ECOLI Escherichia coli (strain K12) # PATRIC 32117321 VBIEscCol129921_1083 # PIR S70788 S70788 # Pfam PF07012 Curlin_rpt; 3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CSGA_ECOLI Major curlin subunit # RefSeq NP_415560 NC_000913.3 # RefSeq WP_000771437 NZ_LN832404.1 # SIMILARITY Belongs to the CsgA/CsgB family. {ECO 0000305}. # SUBCELLULAR LOCATION CSGA_ECOLI Fimbrium. Note=Part of the curli surface structure. # eggNOG ENOG4105G76 Bacteria # eggNOG ENOG4111QFZ LUCA BLAST swissprot:CSGA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CSGA_ECOLI BioCyc ECOL316407:JW1025-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1025-MONOMER BioCyc EcoCyc:EG11489-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11489-MONOMER DIP DIP-9325N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9325N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1993.tb01143.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb01143.x DOI 10.1111/j.1365-2958.1995.mmi_18040661.x http://dx.doi.org/10.1111/j.1365-2958.1995.mmi_18040661.x DOI 10.1111/j.1365-2958.2006.05440.x http://dx.doi.org/10.1111/j.1365-2958.2006.05440.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L04979 http://www.ebi.ac.uk/ena/data/view/L04979 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X90754 http://www.ebi.ac.uk/ena/data/view/X90754 EchoBASE EB1452 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1452 EcoGene EG11489 http://www.ecogene.org/geneInfo.php?eg_id=EG11489 EnsemblBacteria AAC74126 http://www.ensemblgenomes.org/id/AAC74126 EnsemblBacteria AAC74126 http://www.ensemblgenomes.org/id/AAC74126 EnsemblBacteria BAA35832 http://www.ensemblgenomes.org/id/BAA35832 EnsemblBacteria BAA35832 http://www.ensemblgenomes.org/id/BAA35832 EnsemblBacteria BAA35832 http://www.ensemblgenomes.org/id/BAA35832 EnsemblBacteria b1042 http://www.ensemblgenomes.org/id/b1042 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009289 GO_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GO_process GO:0044010 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044010 GO_process GO:1990000 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990000 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0030198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030198 GeneID 949055 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949055 HOGENOM HOG000118951 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118951&db=HOGENOM6 InParanoid P28307 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P28307 InterPro IPR009742 http://www.ebi.ac.uk/interpro/entry/IPR009742 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW1025 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1025 KEGG_Gene eco:b1042 http://www.genome.jp/dbget-bin/www_bget?eco:b1042 KEGG_Orthology KO:K04334 http://www.genome.jp/dbget-bin/www_bget?KO:K04334 OMA NSEIQIY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NSEIQIY PSORT swissprot:CSGA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CSGA_ECOLI PSORT-B swissprot:CSGA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CSGA_ECOLI PSORT2 swissprot:CSGA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CSGA_ECOLI Pfam PF07012 http://pfam.xfam.org/family/PF07012 Phobius swissprot:CSGA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CSGA_ECOLI PhylomeDB P28307 http://phylomedb.org/?seqid=P28307 ProteinModelPortal P28307 http://www.proteinmodelportal.org/query/uniprot/P28307 PubMed 1357528 http://www.ncbi.nlm.nih.gov/pubmed/1357528 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1677357 http://www.ncbi.nlm.nih.gov/pubmed/1677357 PubMed 17010156 http://www.ncbi.nlm.nih.gov/pubmed/17010156 PubMed 8459772 http://www.ncbi.nlm.nih.gov/pubmed/8459772 PubMed 8817489 http://www.ncbi.nlm.nih.gov/pubmed/8817489 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415560 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415560 RefSeq WP_000771437 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000771437 STRING 511145.b1042 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1042&targetmode=cogs UniProtKB CSGA_ECOLI http://www.uniprot.org/uniprot/CSGA_ECOLI UniProtKB-AC P28307 http://www.uniprot.org/uniprot/P28307 charge swissprot:CSGA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CSGA_ECOLI eggNOG ENOG4105G76 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105G76 eggNOG ENOG4111QFZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111QFZ epestfind swissprot:CSGA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CSGA_ECOLI garnier swissprot:CSGA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CSGA_ECOLI helixturnhelix swissprot:CSGA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CSGA_ECOLI hmoment swissprot:CSGA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CSGA_ECOLI iep swissprot:CSGA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CSGA_ECOLI inforesidue swissprot:CSGA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CSGA_ECOLI octanol swissprot:CSGA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CSGA_ECOLI pepcoil swissprot:CSGA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CSGA_ECOLI pepdigest swissprot:CSGA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CSGA_ECOLI pepinfo swissprot:CSGA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CSGA_ECOLI pepnet swissprot:CSGA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CSGA_ECOLI pepstats swissprot:CSGA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CSGA_ECOLI pepwheel swissprot:CSGA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CSGA_ECOLI pepwindow swissprot:CSGA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CSGA_ECOLI sigcleave swissprot:CSGA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CSGA_ECOLI ## Database ID URL or Descriptions # EcoGene EG11301 ydfB # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GOslim_component GO:0005737 cytoplasm # INDUCTION Constitutively expressed (at protein level). {ECO:0000269|PubMed 19121005}. # Organism YDFB_ECOLI Escherichia coli (strain K12) # PATRIC 32118444 VBIEscCol129921_1642 # PIR G64912 G64912 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDFB_ECOLI Uncharacterized protein YdfB # RefSeq NP_416090 NC_000913.3 # SUBCELLULAR LOCATION YDFB_ECOLI Cytoplasm {ECO 0000269|PubMed 21778229}. Note=Probably associated with the inner membrane. BLAST swissprot:YDFB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDFB_ECOLI BioCyc ECOL316407:JW1564-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1564-MONOMER BioCyc EcoCyc:EG11301-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11301-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M111.245696 http://dx.doi.org/10.1074/jbc.M111.245696 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/16.14.6327 http://dx.doi.org/10.1093/nar/16.14.6327 DOI 10.1111/j.1365-2958.2008.06495.x http://dx.doi.org/10.1111/j.1365-2958.2008.06495.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X07465 http://www.ebi.ac.uk/ena/data/view/X07465 EchoBASE EB1278 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1278 EcoGene EG11301 http://www.ecogene.org/geneInfo.php?eg_id=EG11301 EnsemblBacteria AAC74645 http://www.ensemblgenomes.org/id/AAC74645 EnsemblBacteria AAC74645 http://www.ensemblgenomes.org/id/AAC74645 EnsemblBacteria BAA15277 http://www.ensemblgenomes.org/id/BAA15277 EnsemblBacteria BAA15277 http://www.ensemblgenomes.org/id/BAA15277 EnsemblBacteria BAA15277 http://www.ensemblgenomes.org/id/BAA15277 EnsemblBacteria b1572 http://www.ensemblgenomes.org/id/b1572 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GeneID 946176 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946176 HOGENOM HOG000050181 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000050181&db=HOGENOM6 KEGG_Gene ecj:JW1564 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1564 KEGG_Gene eco:b1572 http://www.genome.jp/dbget-bin/www_bget?eco:b1572 PSORT swissprot:YDFB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDFB_ECOLI PSORT-B swissprot:YDFB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDFB_ECOLI PSORT2 swissprot:YDFB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDFB_ECOLI Phobius swissprot:YDFB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDFB_ECOLI ProteinModelPortal P29009 http://www.proteinmodelportal.org/query/uniprot/P29009 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19121005 http://www.ncbi.nlm.nih.gov/pubmed/19121005 PubMed 21778229 http://www.ncbi.nlm.nih.gov/pubmed/21778229 PubMed 3041373 http://www.ncbi.nlm.nih.gov/pubmed/3041373 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416090 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416090 STRING 511145.b1572 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1572&targetmode=cogs UniProtKB YDFB_ECOLI http://www.uniprot.org/uniprot/YDFB_ECOLI UniProtKB-AC P29009 http://www.uniprot.org/uniprot/P29009 charge swissprot:YDFB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDFB_ECOLI epestfind swissprot:YDFB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDFB_ECOLI garnier swissprot:YDFB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDFB_ECOLI helixturnhelix swissprot:YDFB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDFB_ECOLI hmoment swissprot:YDFB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDFB_ECOLI iep swissprot:YDFB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDFB_ECOLI inforesidue swissprot:YDFB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDFB_ECOLI octanol swissprot:YDFB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDFB_ECOLI pepcoil swissprot:YDFB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDFB_ECOLI pepdigest swissprot:YDFB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDFB_ECOLI pepinfo swissprot:YDFB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDFB_ECOLI pepnet swissprot:YDFB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDFB_ECOLI pepstats swissprot:YDFB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDFB_ECOLI pepwheel swissprot:YDFB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDFB_ECOLI pepwindow swissprot:YDFB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDFB_ECOLI sigcleave swissprot:YDFB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDFB_ECOLI ## Database ID URL or Descriptions # BioGrid 4261946 179 # EcoGene EG13359 ydaQ # InterPro IPR009634 Phage_933W_Xis # Organism YDAQ_ECOLI Escherichia coli (strain K12) # PATRIC 32117972 VBIEscCol129921_1406 # Pfam PF06806 DUF1233 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDAQ_ECOLI Uncharacterized protein YdaQ # RefSeq NP_415862 NC_000913.3 # RefSeq WP_000079604 NZ_CP014272.1 # eggNOG ENOG4107160 Bacteria # eggNOG ENOG410YTX8 LUCA BLAST swissprot:YDAQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDAQ_ECOLI BioCyc ECOL316407:JW5207-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5207-MONOMER BioCyc EcoCyc:G6677-MONOMER http://biocyc.org/getid?id=EcoCyc:G6677-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3142 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3142 EcoGene EG13359 http://www.ecogene.org/geneInfo.php?eg_id=EG13359 EnsemblBacteria AAC74428 http://www.ensemblgenomes.org/id/AAC74428 EnsemblBacteria AAC74428 http://www.ensemblgenomes.org/id/AAC74428 EnsemblBacteria BAE76409 http://www.ensemblgenomes.org/id/BAE76409 EnsemblBacteria BAE76409 http://www.ensemblgenomes.org/id/BAE76409 EnsemblBacteria BAE76409 http://www.ensemblgenomes.org/id/BAE76409 EnsemblBacteria b1346 http://www.ensemblgenomes.org/id/b1346 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947399 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947399 HOGENOM HOG000294448 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000294448&db=HOGENOM6 InterPro IPR009634 http://www.ebi.ac.uk/interpro/entry/IPR009634 KEGG_Gene ecj:JW5207 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5207 KEGG_Gene eco:b1346 http://www.genome.jp/dbget-bin/www_bget?eco:b1346 OMA GVHFKRL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GVHFKRL PSORT swissprot:YDAQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDAQ_ECOLI PSORT-B swissprot:YDAQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDAQ_ECOLI PSORT2 swissprot:YDAQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDAQ_ECOLI Pfam PF06806 http://pfam.xfam.org/family/PF06806 Phobius swissprot:YDAQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDAQ_ECOLI ProteinModelPortal P76057 http://www.proteinmodelportal.org/query/uniprot/P76057 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415862 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415862 RefSeq WP_000079604 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000079604 SMR P76057 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76057 STRING 511145.b1346 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1346&targetmode=cogs UniProtKB YDAQ_ECOLI http://www.uniprot.org/uniprot/YDAQ_ECOLI UniProtKB-AC P76057 http://www.uniprot.org/uniprot/P76057 charge swissprot:YDAQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDAQ_ECOLI eggNOG ENOG4107160 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107160 eggNOG ENOG410YTX8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YTX8 epestfind swissprot:YDAQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDAQ_ECOLI garnier swissprot:YDAQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDAQ_ECOLI helixturnhelix swissprot:YDAQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDAQ_ECOLI hmoment swissprot:YDAQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDAQ_ECOLI iep swissprot:YDAQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDAQ_ECOLI inforesidue swissprot:YDAQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDAQ_ECOLI octanol swissprot:YDAQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDAQ_ECOLI pepcoil swissprot:YDAQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDAQ_ECOLI pepdigest swissprot:YDAQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDAQ_ECOLI pepinfo swissprot:YDAQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDAQ_ECOLI pepnet swissprot:YDAQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDAQ_ECOLI pepstats swissprot:YDAQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDAQ_ECOLI pepwheel swissprot:YDAQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDAQ_ECOLI pepwindow swissprot:YDAQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDAQ_ECOLI sigcleave swissprot:YDAQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDAQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4263284 15 # CDD cd00002 YbaK_deacylase # DISRUPTION PHENOTYPE Non-essential gene. {ECO:0000269|PubMed 15886196}. # EcoGene EG12454 ybaK # FUNCTION YBAK_ECOLI Functions in trans to edit the amino acid from incorrectly charged Cys-tRNA(Pro) via a Cys-tRNA(Pro) deacylase activity. May compensate for the lack of Cys-tRNA(Pro) editing by ProRS. Is also able to deacylate Cys-tRNA(Cys), and displays weak deacylase activity in vitro against Gly-tRNA(Gly), as well as, at higher concentrations, some other correctly charged tRNAs. Unlike some of its orthologs it is not able to remove the amino acid moiety from incorrectly charged Ala-tRNA(Pro). {ECO 0000269|PubMed 15886196, ECO 0000269|PubMed 23185990}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0002161 aminoacyl-tRNA editing activity; IDA:UniProtKB. # GO_function GO:0016829 lyase activity; IEA:UniProtKB-KW. # GO_function GO:0043907 Cys-tRNA(Pro) hydrolase activity; IDA:EcoCyc. # GO_process GO:0006412 translation; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0006412 translation # Gene3D 3.90.960.10 -; 1. # IntAct P0AAR3 17 # InterPro IPR004369 Prolyl-tRNA_editing_YbaK/EbsC # InterPro IPR007214 YbaK/aa-tRNA-synth-assoc-dom # MISCELLANEOUS YBAK_ECOLI Has been suggested to be potentially involved in suppression of transcription of ushA. # MISCELLANEOUS YBAK_ECOLI Reaction mechanism involves exclusion of catalytic water from the active site and substrate-mediated catalysis the sulfhydryl side chain of the Cys substrate acts as a nucleophile and attacks the carbonyl center of the ester bond, leading to the cleavage of the Cys-tRNA ester bond and formation of a cyclic cysteine thiolactone intermediate. In contrast, the INS editing domain of ProRS catalyzes Ala-tRNA(Pro) hydrolysis via nucleophilic attack by a catalytic water molecule (PubMed 23185990). {ECO 0000305|PubMed 23185990}. # Organism YBAK_ECOLI Escherichia coli (strain K12) # PATRIC 32116119 VBIEscCol129921_0501 # PDB 2DXA X-ray; 1.58 A; A=1-159 # PIR H64778 H64778 # PIRSF PIRSF006181 EbsC_YbaK # Pfam PF04073 tRNA_edit # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBAK_ECOLI Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK # RefSeq NP_415014 NC_000913.3 # RefSeq WP_000186631 NZ_LN832404.1 # SIMILARITY Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION YBAK_ECOLI Cytoplasm {ECO 0000250}. # SUPFAM SSF55826 SSF55826 # TIGRFAMs TIGR00011 YbaK_EbsC # eggNOG COG2606 LUCA # eggNOG ENOG4108Z66 Bacteria BLAST swissprot:YBAK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBAK_ECOLI BioCyc ECOL316407:JW0470-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0470-MONOMER BioCyc EcoCyc:EG12454-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12454-MONOMER DIP DIP-48133N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48133N DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1021/jp308628y http://dx.doi.org/10.1021/jp308628y DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.2136934100 http://dx.doi.org/10.1073/pnas.2136934100 DOI 10.1074/jbc.M502174200 http://dx.doi.org/10.1074/jbc.M502174200 DOI 10.1093/nar/14.10.4325 http://dx.doi.org/10.1093/nar/14.10.4325 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.-.- http://www.genome.jp/dbget-bin/www_bget?EC:4.2.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL X03895 http://www.ebi.ac.uk/ena/data/view/X03895 ENZYME 4.2.-.- http://enzyme.expasy.org/EC/4.2.-.- EchoBASE EB2348 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2348 EcoGene EG12454 http://www.ecogene.org/geneInfo.php?eg_id=EG12454 EnsemblBacteria AAC73583 http://www.ensemblgenomes.org/id/AAC73583 EnsemblBacteria AAC73583 http://www.ensemblgenomes.org/id/AAC73583 EnsemblBacteria BAE76260 http://www.ensemblgenomes.org/id/BAE76260 EnsemblBacteria BAE76260 http://www.ensemblgenomes.org/id/BAE76260 EnsemblBacteria BAE76260 http://www.ensemblgenomes.org/id/BAE76260 EnsemblBacteria b0481 http://www.ensemblgenomes.org/id/b0481 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0002161 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002161 GO_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GO_function GO:0043907 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043907 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 Gene3D 3.90.960.10 http://www.cathdb.info/version/latest/superfamily/3.90.960.10 GeneID 947083 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947083 HOGENOM HOG000262090 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000262090&db=HOGENOM6 InParanoid P0AAR3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAR3 IntAct P0AAR3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAR3* IntEnz 4.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2 InterPro IPR004369 http://www.ebi.ac.uk/interpro/entry/IPR004369 InterPro IPR007214 http://www.ebi.ac.uk/interpro/entry/IPR007214 KEGG_Gene ecj:JW0470 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0470 KEGG_Gene eco:b0481 http://www.genome.jp/dbget-bin/www_bget?eco:b0481 MINT MINT-1228144 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1228144 OMA FTVHAYD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FTVHAYD PDB 2DXA http://www.ebi.ac.uk/pdbe-srv/view/entry/2DXA PDBsum 2DXA http://www.ebi.ac.uk/pdbsum/2DXA PSORT swissprot:YBAK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBAK_ECOLI PSORT-B swissprot:YBAK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBAK_ECOLI PSORT2 swissprot:YBAK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBAK_ECOLI Pfam PF04073 http://pfam.xfam.org/family/PF04073 Phobius swissprot:YBAK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBAK_ECOLI PhylomeDB P0AAR3 http://phylomedb.org/?seqid=P0AAR3 ProteinModelPortal P0AAR3 http://www.proteinmodelportal.org/query/uniprot/P0AAR3 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 14663147 http://www.ncbi.nlm.nih.gov/pubmed/14663147 PubMed 15886196 http://www.ncbi.nlm.nih.gov/pubmed/15886196 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 23185990 http://www.ncbi.nlm.nih.gov/pubmed/23185990 PubMed 3012467 http://www.ncbi.nlm.nih.gov/pubmed/3012467 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415014 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415014 RefSeq WP_000186631 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000186631 SMR P0AAR3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAR3 STRING 511145.b0481 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0481&targetmode=cogs SUPFAM SSF55826 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55826 TIGRFAMs TIGR00011 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00011 UniProtKB YBAK_ECOLI http://www.uniprot.org/uniprot/YBAK_ECOLI UniProtKB-AC P0AAR3 http://www.uniprot.org/uniprot/P0AAR3 charge swissprot:YBAK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBAK_ECOLI eggNOG COG2606 http://eggnogapi.embl.de/nog_data/html/tree/COG2606 eggNOG ENOG4108Z66 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Z66 epestfind swissprot:YBAK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBAK_ECOLI garnier swissprot:YBAK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBAK_ECOLI helixturnhelix swissprot:YBAK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBAK_ECOLI hmoment swissprot:YBAK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBAK_ECOLI iep swissprot:YBAK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBAK_ECOLI inforesidue swissprot:YBAK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBAK_ECOLI octanol swissprot:YBAK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBAK_ECOLI pepcoil swissprot:YBAK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBAK_ECOLI pepdigest swissprot:YBAK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBAK_ECOLI pepinfo swissprot:YBAK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBAK_ECOLI pepnet swissprot:YBAK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBAK_ECOLI pepstats swissprot:YBAK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBAK_ECOLI pepwheel swissprot:YBAK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBAK_ECOLI pepwindow swissprot:YBAK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBAK_ECOLI sigcleave swissprot:YBAK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBAK_ECOLI ## Database ID URL or Descriptions # AltName DKGB_ECOLI AKR5D # BIOPHYSICOCHEMICAL PROPERTIES pH dependence Optimum pH is 7.0.; # BRENDA 1.1.1.274 2026 # BioGrid 4261784 5 # CATALYTIC ACTIVITY DKGB_ECOLI 2-dehydro-L-gulonate + NADP(+) = 2,5- didehydro-D-gluconate + NADPH. # CDD cd06660 Aldo_ket_red # EcoGene EG11648 dkgB # FUNCTION DKGB_ECOLI Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0004033 aldo-keto reductase (NADP) activity; IDA:EcoCyc. # GO_function GO:0047681 aryl-alcohol dehydrogenase (NADP+) activity; IDA:EcoCyc. # GO_function GO:1990002 methylglyoxal reductase (NADPH-dependent, acetol producing); IDA:EcoCyc. # GO_process GO:0019853 L-ascorbic acid biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0051596 methylglyoxal catabolic process; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.100 -; 1. # InterPro IPR001395 Aldo/ket_red/Kv-b # InterPro IPR018170 Aldo/ket_reductase_CS # InterPro IPR020471 Aldo/keto_reductase # InterPro IPR023210 NADP_OxRdtase_dom # KEGG_Brite ko01000 Enzymes # MISCELLANEOUS DKGB_ECOLI 2-keto-L-gulonic acid is a key intermediate in the production of L-ascorbic acid (vitamin C). # Organism DKGB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11732 PTHR11732 # PATRIC 32115527 VBIEscCol129921_0209 # PIR A64745 A64745 # PIRSF PIRSF000097 AKR # PRINTS PR00069 ALDKETRDTASE # PROSITE PS00062 ALDOKETO_REDUCTASE_2 # PROSITE PS00798 ALDOKETO_REDUCTASE_1 # Pfam PF00248 Aldo_ket_red # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DKGB_ECOLI 2,5-diketo-D-gluconic acid reductase B # RefSeq NP_414743 NC_000913.3 # RefSeq WP_000997010 NZ_LN832404.1 # SIMILARITY Belongs to the aldo/keto reductase family. {ECO 0000305}. # SUBCELLULAR LOCATION DKGB_ECOLI Cytoplasm {ECO 0000250}. # SUBUNIT DKGB_ECOLI Monomer. # SUPFAM SSF51430 SSF51430 # eggNOG COG0656 LUCA # eggNOG ENOG4105CV8 Bacteria BLAST swissprot:DKGB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DKGB_ECOLI BioCyc ECOL316407:JW0197-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0197-MONOMER BioCyc EcoCyc:MONOMER0-149 http://biocyc.org/getid?id=EcoCyc:MONOMER0-149 BioCyc MetaCyc:MONOMER0-149 http://biocyc.org/getid?id=MetaCyc:MONOMER0-149 COG COG0656 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0656 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/8.17.3809 http://dx.doi.org/10.1093/nar/8.17.3809 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.346 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.346 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D12650 http://www.ebi.ac.uk/ena/data/view/D12650 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EMBL V00336 http://www.ebi.ac.uk/ena/data/view/V00336 ENZYME 1.1.1.346 http://enzyme.expasy.org/EC/1.1.1.346 EchoBASE EB1601 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1601 EcoGene EG11648 http://www.ecogene.org/geneInfo.php?eg_id=EG11648 EnsemblBacteria AAC73312 http://www.ensemblgenomes.org/id/AAC73312 EnsemblBacteria AAC73312 http://www.ensemblgenomes.org/id/AAC73312 EnsemblBacteria BAA77878 http://www.ensemblgenomes.org/id/BAA77878 EnsemblBacteria BAA77878 http://www.ensemblgenomes.org/id/BAA77878 EnsemblBacteria BAA77878 http://www.ensemblgenomes.org/id/BAA77878 EnsemblBacteria b0207 http://www.ensemblgenomes.org/id/b0207 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004033 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004033 GO_function GO:0047681 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047681 GO_function GO:1990002 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990002 GO_process GO:0019853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019853 GO_process GO:0051596 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051596 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.100 http://www.cathdb.info/version/latest/superfamily/3.20.20.100 GeneID 944901 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944901 HOGENOM HOG000250272 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000250272&db=HOGENOM6 InParanoid P30863 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30863 IntAct P30863 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P30863* IntEnz 1.1.1.346 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.346 InterPro IPR001395 http://www.ebi.ac.uk/interpro/entry/IPR001395 InterPro IPR018170 http://www.ebi.ac.uk/interpro/entry/IPR018170 InterPro IPR020471 http://www.ebi.ac.uk/interpro/entry/IPR020471 InterPro IPR023210 http://www.ebi.ac.uk/interpro/entry/IPR023210 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0197 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0197 KEGG_Gene eco:b0207 http://www.genome.jp/dbget-bin/www_bget?eco:b0207 KEGG_Orthology KO:K06222 http://www.genome.jp/dbget-bin/www_bget?KO:K06222 OMA QKLRTDH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QKLRTDH PANTHER PTHR11732 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11732 PRINTS PR00069 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00069 PROSITE PS00062 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00062 PROSITE PS00798 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00798 PSORT swissprot:DKGB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DKGB_ECOLI PSORT-B swissprot:DKGB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DKGB_ECOLI PSORT2 swissprot:DKGB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DKGB_ECOLI Pfam PF00248 http://pfam.xfam.org/family/PF00248 Phobius swissprot:DKGB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DKGB_ECOLI PhylomeDB P30863 http://phylomedb.org/?seqid=P30863 ProteinModelPortal P30863 http://www.proteinmodelportal.org/query/uniprot/P30863 PubMed 10427017 http://www.ncbi.nlm.nih.gov/pubmed/10427017 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6255418 http://www.ncbi.nlm.nih.gov/pubmed/6255418 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414743 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414743 RefSeq WP_000997010 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000997010 SMR P30863 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P30863 STRING 511145.b0207 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0207&targetmode=cogs STRING COG0656 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0656&targetmode=cogs SUPFAM SSF51430 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51430 UniProtKB DKGB_ECOLI http://www.uniprot.org/uniprot/DKGB_ECOLI UniProtKB-AC P30863 http://www.uniprot.org/uniprot/P30863 charge swissprot:DKGB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DKGB_ECOLI eggNOG COG0656 http://eggnogapi.embl.de/nog_data/html/tree/COG0656 eggNOG ENOG4105CV8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CV8 epestfind swissprot:DKGB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DKGB_ECOLI garnier swissprot:DKGB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DKGB_ECOLI helixturnhelix swissprot:DKGB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DKGB_ECOLI hmoment swissprot:DKGB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DKGB_ECOLI iep swissprot:DKGB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DKGB_ECOLI inforesidue swissprot:DKGB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DKGB_ECOLI octanol swissprot:DKGB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DKGB_ECOLI pepcoil swissprot:DKGB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DKGB_ECOLI pepdigest swissprot:DKGB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DKGB_ECOLI pepinfo swissprot:DKGB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DKGB_ECOLI pepnet swissprot:DKGB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DKGB_ECOLI pepstats swissprot:DKGB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DKGB_ECOLI pepwheel swissprot:DKGB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DKGB_ECOLI pepwindow swissprot:DKGB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DKGB_ECOLI sigcleave swissprot:DKGB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DKGB_ECOLI ## Database ID URL or Descriptions # AltName RSMD_ECOLI 16S rRNA m2G966 methyltransferase # AltName RSMD_ECOLI rRNA (guanine-N(2)-)-methyltransferase # BRENDA 2.1.1.171 2026 # BioGrid 4262500 46 # CATALYTIC ACTIVITY RSMD_ECOLI S-adenosyl-L-methionine + guanine(966) in 16S rRNA = S-adenosyl-L-homocysteine + N(2)-methylguanine(966) in 16S rRNA. # EcoGene EG10343 rsmD # FUNCTION RSMD_ECOLI Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle. {ECO 0000269|PubMed 17189261}. # GO_function GO:0003676 nucleic acid binding; IEA:InterPro. # GO_function GO:0052913 16S rRNA (guanine(966)-N(2))-methyltransferase activity; IDA:EcoCyc. # GO_process GO:0070475 rRNA base methylation; IMP:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.50.150 -; 1. # IntAct P0ADX9 6 # InterPro IPR002052 DNA_methylase_N6_adenine_CS # InterPro IPR004398 RNA_MeTrfase_RsmD # InterPro IPR029063 SAM-dependent_MTases # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # Organism RSMD_ECOLI Escherichia coli (strain K12) # PATRIC 32122374 VBIEscCol129921_3564 # PDB 2FPO X-ray; 2.05 A; A/B/C/D/E/F=1-198 # PIR S03129 QQECX3 # PIRSF PIRSF004553 CHP00095 # PROSITE PS00092 N6_MTASE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RSMD_ECOLI Ribosomal RNA small subunit methyltransferase D # RefSeq NP_417922 NC_000913.3 # RefSeq WP_000743193 NZ_LN832404.1 # SIMILARITY Belongs to the methyltransferase superfamily. RsmD family. {ECO 0000305}. # SUPFAM SSF53335 SSF53335 # TIGRFAMs TIGR00095 TIGR00095 # eggNOG COG0742 LUCA # eggNOG ENOG4106H78 Bacteria BLAST swissprot:RSMD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RSMD_ECOLI BioCyc ECOL316407:JW3430-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3430-MONOMER BioCyc EcoCyc:EG10343-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10343-MONOMER BioCyc MetaCyc:EG10343-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10343-MONOMER COG COG0742 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0742 DIP DIP-48275N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48275N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1007/BF02428043 http://dx.doi.org/10.1007/BF02428043 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M608214200 http://dx.doi.org/10.1074/jbc.M608214200 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.1.171 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.171 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X04398 http://www.ebi.ac.uk/ena/data/view/X04398 ENZYME 2.1.1.171 http://enzyme.expasy.org/EC/2.1.1.171 EchoBASE EB0339 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0339 EcoGene EG10343 http://www.ecogene.org/geneInfo.php?eg_id=EG10343 EnsemblBacteria AAC76490 http://www.ensemblgenomes.org/id/AAC76490 EnsemblBacteria AAC76490 http://www.ensemblgenomes.org/id/AAC76490 EnsemblBacteria BAE77828 http://www.ensemblgenomes.org/id/BAE77828 EnsemblBacteria BAE77828 http://www.ensemblgenomes.org/id/BAE77828 EnsemblBacteria BAE77828 http://www.ensemblgenomes.org/id/BAE77828 EnsemblBacteria b3465 http://www.ensemblgenomes.org/id/b3465 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003676 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003676 GO_function GO:0052913 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052913 GO_process GO:0070475 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070475 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 GeneID 947977 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947977 HOGENOM HOG000050676 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000050676&db=HOGENOM6 InParanoid P0ADX9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADX9 IntAct P0ADX9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADX9* IntEnz 2.1.1.171 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.171 InterPro IPR002052 http://www.ebi.ac.uk/interpro/entry/IPR002052 InterPro IPR004398 http://www.ebi.ac.uk/interpro/entry/IPR004398 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW3430 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3430 KEGG_Gene eco:b3465 http://www.genome.jp/dbget-bin/www_bget?eco:b3465 KEGG_Orthology KO:K08316 http://www.genome.jp/dbget-bin/www_bget?KO:K08316 KEGG_Reaction rn:R07234 http://www.genome.jp/dbget-bin/www_bget?rn:R07234 MINT MINT-1267285 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1267285 OMA MVDARCL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MVDARCL PDB 2FPO http://www.ebi.ac.uk/pdbe-srv/view/entry/2FPO PDBsum 2FPO http://www.ebi.ac.uk/pdbsum/2FPO PROSITE PS00092 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00092 PSORT swissprot:RSMD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RSMD_ECOLI PSORT-B swissprot:RSMD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RSMD_ECOLI PSORT2 swissprot:RSMD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RSMD_ECOLI Phobius swissprot:RSMD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RSMD_ECOLI PhylomeDB P0ADX9 http://phylomedb.org/?seqid=P0ADX9 ProteinModelPortal P0ADX9 http://www.proteinmodelportal.org/query/uniprot/P0ADX9 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17189261 http://www.ncbi.nlm.nih.gov/pubmed/17189261 PubMed 3025556 http://www.ncbi.nlm.nih.gov/pubmed/3025556 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417922 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417922 RefSeq WP_000743193 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000743193 SMR P0ADX9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADX9 STRING 511145.b3465 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3465&targetmode=cogs STRING COG0742 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0742&targetmode=cogs SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 SWISS-2DPAGE P0ADX9 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0ADX9 TIGRFAMs TIGR00095 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00095 UniProtKB RSMD_ECOLI http://www.uniprot.org/uniprot/RSMD_ECOLI UniProtKB-AC P0ADX9 http://www.uniprot.org/uniprot/P0ADX9 charge swissprot:RSMD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RSMD_ECOLI eggNOG COG0742 http://eggnogapi.embl.de/nog_data/html/tree/COG0742 eggNOG ENOG4106H78 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106H78 epestfind swissprot:RSMD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RSMD_ECOLI garnier swissprot:RSMD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RSMD_ECOLI helixturnhelix swissprot:RSMD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RSMD_ECOLI hmoment swissprot:RSMD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RSMD_ECOLI iep swissprot:RSMD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RSMD_ECOLI inforesidue swissprot:RSMD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RSMD_ECOLI octanol swissprot:RSMD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RSMD_ECOLI pepcoil swissprot:RSMD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RSMD_ECOLI pepdigest swissprot:RSMD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RSMD_ECOLI pepinfo swissprot:RSMD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RSMD_ECOLI pepnet swissprot:RSMD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RSMD_ECOLI pepstats swissprot:RSMD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RSMD_ECOLI pepwheel swissprot:RSMD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RSMD_ECOLI pepwindow swissprot:RSMD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RSMD_ECOLI sigcleave swissprot:RSMD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RSMD_ECOLI ## Database ID URL or Descriptions # BioGrid 4259329 70 # EcoGene EG12841 yrdD # GO_component GO:0005694 chromosome; IEA:InterPro. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0003697 single-stranded DNA binding; IDA:EcoCyc. # GO_function GO:0003916 DNA topoisomerase activity; IBA:GO_Central. # GO_function GO:0003917 DNA topoisomerase type I activity; IEA:InterPro. # GO_function GO:0005506 iron ion binding; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_process GO:0006265 DNA topological change; IBA:GO_Central. # GOslim_component GO:0005694 chromosome # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0051276 chromosome organization # IntAct P45771 7 # InterPro IPR000380 Topo_IA # InterPro IPR013498 Topo_IA_Znf # Organism YRDD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11390 PTHR11390 # PATRIC 32122000 VBIEscCol129921_3377 # PIR F65120 F65120 # Pfam PF01396 zf-C4_Topoisom; 4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YRDD_ECOLI Uncharacterized protein YrdD # RefSeq WP_001129722 NZ_LN832404.1 # RefSeq YP_026210 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA58080.1; Type=Frameshift; Positions=26; Evidence={ECO 0000305}; # SIMILARITY To H.influenzae HI_0656.1. {ECO 0000305}. # eggNOG COG0551 LUCA # eggNOG ENOG4108WI1 Bacteria BLAST swissprot:YRDD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YRDD_ECOLI BioCyc ECOL316407:JW5949-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5949-MONOMER BioCyc EcoCyc:G7699-MONOMER http://biocyc.org/getid?id=EcoCyc:G7699-MONOMER COG COG0551 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0551 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2690 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2690 EcoGene EG12841 http://www.ecogene.org/geneInfo.php?eg_id=EG12841 EnsemblBacteria AAT48175 http://www.ensemblgenomes.org/id/AAT48175 EnsemblBacteria AAT48175 http://www.ensemblgenomes.org/id/AAT48175 EnsemblBacteria BAE78008 http://www.ensemblgenomes.org/id/BAE78008 EnsemblBacteria BAE78008 http://www.ensemblgenomes.org/id/BAE78008 EnsemblBacteria BAE78008 http://www.ensemblgenomes.org/id/BAE78008 EnsemblBacteria b3283 http://www.ensemblgenomes.org/id/b3283 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005694 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005694 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003697 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003697 GO_function GO:0003916 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003916 GO_function GO:0003917 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003917 GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_process GO:0006265 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006265 GOslim_component GO:0005694 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005694 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0051276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051276 GeneID 947782 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947782 HOGENOM HOG000270078 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000270078&db=HOGENOM6 InParanoid P45771 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45771 IntAct P45771 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45771* InterPro IPR000380 http://www.ebi.ac.uk/interpro/entry/IPR000380 InterPro IPR013498 http://www.ebi.ac.uk/interpro/entry/IPR013498 KEGG_Gene ecj:JW5949 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5949 KEGG_Gene eco:b3283 http://www.genome.jp/dbget-bin/www_bget?eco:b3283 KEGG_Orthology KO:K07479 http://www.genome.jp/dbget-bin/www_bget?KO:K07479 MINT MINT-1244363 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1244363 OMA GRYGMFV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GRYGMFV PANTHER PTHR11390 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11390 PSORT swissprot:YRDD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YRDD_ECOLI PSORT-B swissprot:YRDD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YRDD_ECOLI PSORT2 swissprot:YRDD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YRDD_ECOLI Pfam PF01396 http://pfam.xfam.org/family/PF01396 Phobius swissprot:YRDD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YRDD_ECOLI ProteinModelPortal P45771 http://www.proteinmodelportal.org/query/uniprot/P45771 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001129722 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001129722 RefSeq YP_026210 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026210 STRING 511145.b3283 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3283&targetmode=cogs STRING COG0551 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0551&targetmode=cogs UniProtKB YRDD_ECOLI http://www.uniprot.org/uniprot/YRDD_ECOLI UniProtKB-AC P45771 http://www.uniprot.org/uniprot/P45771 charge swissprot:YRDD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YRDD_ECOLI eggNOG COG0551 http://eggnogapi.embl.de/nog_data/html/tree/COG0551 eggNOG ENOG4108WI1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108WI1 epestfind swissprot:YRDD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YRDD_ECOLI garnier swissprot:YRDD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YRDD_ECOLI helixturnhelix swissprot:YRDD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YRDD_ECOLI hmoment swissprot:YRDD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YRDD_ECOLI iep swissprot:YRDD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YRDD_ECOLI inforesidue swissprot:YRDD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YRDD_ECOLI octanol swissprot:YRDD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YRDD_ECOLI pepcoil swissprot:YRDD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YRDD_ECOLI pepdigest swissprot:YRDD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YRDD_ECOLI pepinfo swissprot:YRDD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YRDD_ECOLI pepnet swissprot:YRDD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YRDD_ECOLI pepstats swissprot:YRDD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YRDD_ECOLI pepwheel swissprot:YRDD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YRDD_ECOLI pepwindow swissprot:YRDD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YRDD_ECOLI sigcleave swissprot:YRDD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YRDD_ECOLI ## Database ID URL or Descriptions # AltName ATP-AMP transphosphorylase {ECO:0000255|HAMAP-Rule MF_00235} # AltName ATP:AMP phosphotransferase {ECO 0000255|HAMAP-Rule:MF_00235} # AltName Adenylate monophosphate kinase {ECO:0000255|HAMAP-Rule MF_00235} # BIOPHYSICOCHEMICAL PROPERTIES KAD_ECOLI Kinetic parameters KM=51 uM for ATP (at pH 7.4 and 30 degrees Celsius) {ECO 0000269|PubMed 10398370}; KM=38 uM for AMP (at pH 7.4 and 30 degrees Celsius) {ECO 0000269|PubMed 10398370}; KM=92 uM for ADP (at pH 7.4 and 30 degrees Celsius) {ECO 0000269|PubMed 10398370}; Vmax=1020 umol/min/mg enzyme for the forward reaction (at pH 7.4 and 30 degrees Celsius) {ECO 0000269|PubMed 10398370}; Vmax=605 umol/min/mg enzyme for the reverse reaction (at pH 7.4 and 30 degrees Celsius) {ECO 0000269|PubMed 10398370}; Temperature dependence Optimum temperature is 45 degrees Celsius. Thermostable. Is half-inactivated at 52 degrees Celsius. {ECO 0000269|PubMed 10398370}; # BRENDA 2.7.4 2026 # BioGrid 4261613 11 # CATALYTIC ACTIVITY KAD_ECOLI ATP + AMP = 2 ADP. {ECO 0000255|HAMAP- Rule MF_00235, ECO 0000269|PubMed 10398370}. # CDD cd01428 ADK # DOMAIN KAD_ECOLI Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. {ECO 0000255|HAMAP- Rule MF_00235, ECO 0000305|PubMed 8805521}. # EcoGene EG10032 adk # FUNCTION KAD_ECOLI Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. {ECO 0000255|HAMAP-Rule MF_00235, ECO 0000269|PubMed 166976, ECO 0000269|PubMed 6243627}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0004017 adenylate kinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IDA:EcoCyc. # GO_function GO:0016208 AMP binding; IDA:EcoCyc. # GO_process GO:0006172 ADP biosynthetic process; IMP:EcoliWiki. # GO_process GO:0006412 translation; IMP:EcoliWiki. # GO_process GO:0008654 phospholipid biosynthetic process; IMP:EcoliWiki. # GO_process GO:0015951 purine ribonucleotide interconversion; IMP:EcoCyc. # GO_process GO:0032774 RNA biosynthetic process; IMP:EcoliWiki. # GO_process GO:0044209 AMP salvage; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006412 translation # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.300 -; 1. # HAMAP MF_00235 Adenylate_kinase_Adk # INTERACTION KAD_ECOLI P77806 ybdL; NbExp=2; IntAct=EBI-543592, EBI-543661; # IntAct P69441 13 # InterPro IPR000850 Adenylat/UMP-CMP_kin # InterPro IPR006259 Adenyl_kin_sub # InterPro IPR007862 Adenylate_kinase_lid-dom # InterPro IPR027417 P-loop_NTPase # InterPro IPR033690 Adenylat_kinase_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # Organism KAD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR23359 PTHR23359 # PATHWAY Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1. {ECO 0000255|HAMAP-Rule:MF_00235}. # PATRIC 32116105 VBIEscCol129921_0494 # PDB 1AKE X-ray; 2.00 A; A/B=1-214 # PDB 1ANK X-ray; 2.00 A; A/B=1-214 # PDB 1E4V X-ray; 1.85 A; A/B=1-214 # PDB 1E4Y X-ray; 1.85 A; A/B=1-214 # PDB 2ECK X-ray; 2.80 A; A/B=1-214 # PDB 3HPQ X-ray; 2.00 A; A/B=1-214 # PDB 3HPR X-ray; 2.00 A; A/B=1-214 # PDB 4AKE X-ray; 2.20 A; A/B=1-214 # PDB 4X8H X-ray; 2.50 A; A=1-214 # PDB 4X8L X-ray; 1.70 A; A/B=1-214 # PDB 4X8M X-ray; 2.60 A; A=1-214 # PDB 4X8O X-ray; 2.10 A; A/B=1-214 # PIR A24275 KIECA # PRINTS PR00094 ADENYLTKNASE # PROSITE PS00113 ADENYLATE_KINASE # Pfam PF05191 ADK_lid # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Adenylate kinase {ECO:0000255|HAMAP-Rule MF_00235} # RefSeq NP_415007 NC_000913.3 # RefSeq WP_001220233 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40228.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the adenylate kinase family. {ECO:0000255|HAMAP-Rule MF_00235}. # SUBCELLULAR LOCATION KAD_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00235}. # SUBUNIT KAD_ECOLI Monomer. {ECO 0000255|HAMAP-Rule MF_00235, ECO 0000269|PubMed 16302237, ECO 0000269|PubMed 19805185, ECO 0000269|PubMed 8451239}. # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR01351 adk # UniPathway UPA00588 UER00649 # eggNOG COG0563 LUCA # eggNOG ENOG4105CC8 Bacteria BLAST swissprot:KAD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:KAD_ECOLI BioCyc ECOL316407:JW0463-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0463-MONOMER BioCyc EcoCyc:ADENYL-KIN-MONOMER http://biocyc.org/getid?id=EcoCyc:ADENYL-KIN-MONOMER BioCyc MetaCyc:ADENYL-KIN-MONOMER http://biocyc.org/getid?id=MetaCyc:ADENYL-KIN-MONOMER COG COG0563 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0563 DIP DIP-47903N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47903N DOI 10.1002/(SICI)1097-0134(19990801)36:2<238::AID-PROT9>3.0.CO http://dx.doi.org/10.1002/(SICI)1097-0134(19990801)36:2<238::AID-PROT9>3.0.CO DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1002/prot.20699 http://dx.doi.org/10.1002/prot.20699 DOI 10.1002/prot.340150106 http://dx.doi.org/10.1002/prot.340150106 DOI 10.1002/prot.340190304 http://dx.doi.org/10.1002/prot.340190304 DOI 10.1006/jmbi.1998.1726 http://dx.doi.org/10.1006/jmbi.1998.1726 DOI 10.1016/0022-2836(91)90180-E http://dx.doi.org/10.1016/0022-2836(91)90180-E DOI 10.1016/0022-2836(92)90582-5 http://dx.doi.org/10.1016/0022-2836(92)90582-5 DOI 10.1016/S0969-2126(96)00018-4 http://dx.doi.org/10.1016/S0969-2126(96)00018-4 DOI 10.1021/bi00413a020 http://dx.doi.org/10.1021/bi00413a020 DOI 10.1021/bi00484a014 http://dx.doi.org/10.1021/bi00484a014 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0906510106 http://dx.doi.org/10.1073/pnas.0906510106 DOI 10.1073/pnas.84.15.5177 http://dx.doi.org/10.1073/pnas.84.15.5177 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/nar/13.19.7139 http://dx.doi.org/10.1093/nar/13.19.7139 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.4.3 {ECO:0000255|HAMAP-Rule:MF_00235} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.4.3 {ECO:0000255|HAMAP-Rule:MF_00235} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D90259 http://www.ebi.ac.uk/ena/data/view/D90259 EMBL M38777 http://www.ebi.ac.uk/ena/data/view/M38777 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL X03038 http://www.ebi.ac.uk/ena/data/view/X03038 ENZYME 2.7.4.3 {ECO:0000255|HAMAP-Rule:MF_00235} http://enzyme.expasy.org/EC/2.7.4.3 {ECO:0000255|HAMAP-Rule:MF_00235} EchoBASE EB0031 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0031 EcoGene EG10032 http://www.ecogene.org/geneInfo.php?eg_id=EG10032 EnsemblBacteria AAC73576 http://www.ensemblgenomes.org/id/AAC73576 EnsemblBacteria AAC73576 http://www.ensemblgenomes.org/id/AAC73576 EnsemblBacteria BAE76253 http://www.ensemblgenomes.org/id/BAE76253 EnsemblBacteria BAE76253 http://www.ensemblgenomes.org/id/BAE76253 EnsemblBacteria BAE76253 http://www.ensemblgenomes.org/id/BAE76253 EnsemblBacteria b0474 http://www.ensemblgenomes.org/id/b0474 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0004017 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004017 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016208 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016208 GO_process GO:0006172 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006172 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GO_process GO:0008654 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008654 GO_process GO:0015951 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015951 GO_process GO:0032774 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032774 GO_process GO:0044209 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044209 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945097 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945097 HAMAP MF_00235 http://hamap.expasy.org/unirule/MF_00235 HOGENOM HOG000238772 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000238772&db=HOGENOM6 InParanoid P69441 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P69441 IntAct P69441 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69441* IntEnz 2.7.4.3 {ECO:0000255|HAMAP-Rule:MF_00235} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.4.3 {ECO:0000255|HAMAP-Rule:MF_00235} InterPro IPR000850 http://www.ebi.ac.uk/interpro/entry/IPR000850 InterPro IPR006259 http://www.ebi.ac.uk/interpro/entry/IPR006259 InterPro IPR007862 http://www.ebi.ac.uk/interpro/entry/IPR007862 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR033690 http://www.ebi.ac.uk/interpro/entry/IPR033690 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0463 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0463 KEGG_Gene eco:b0474 http://www.genome.jp/dbget-bin/www_bget?eco:b0474 KEGG_Orthology KO:K00939 http://www.genome.jp/dbget-bin/www_bget?KO:K00939 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Reaction rn:R00127 http://www.genome.jp/dbget-bin/www_bget?rn:R00127 KEGG_Reaction rn:R01547 http://www.genome.jp/dbget-bin/www_bget?rn:R01547 OMA RVYHIVF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RVYHIVF PANTHER PTHR23359 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23359 PDB 1AKE http://www.ebi.ac.uk/pdbe-srv/view/entry/1AKE PDB 1ANK http://www.ebi.ac.uk/pdbe-srv/view/entry/1ANK PDB 1E4V http://www.ebi.ac.uk/pdbe-srv/view/entry/1E4V PDB 1E4Y http://www.ebi.ac.uk/pdbe-srv/view/entry/1E4Y PDB 2ECK http://www.ebi.ac.uk/pdbe-srv/view/entry/2ECK PDB 3HPQ http://www.ebi.ac.uk/pdbe-srv/view/entry/3HPQ PDB 3HPR http://www.ebi.ac.uk/pdbe-srv/view/entry/3HPR PDB 4AKE http://www.ebi.ac.uk/pdbe-srv/view/entry/4AKE PDB 4X8H http://www.ebi.ac.uk/pdbe-srv/view/entry/4X8H PDB 4X8L http://www.ebi.ac.uk/pdbe-srv/view/entry/4X8L PDB 4X8M http://www.ebi.ac.uk/pdbe-srv/view/entry/4X8M PDB 4X8O http://www.ebi.ac.uk/pdbe-srv/view/entry/4X8O PDBsum 1AKE http://www.ebi.ac.uk/pdbsum/1AKE PDBsum 1ANK http://www.ebi.ac.uk/pdbsum/1ANK PDBsum 1E4V http://www.ebi.ac.uk/pdbsum/1E4V PDBsum 1E4Y http://www.ebi.ac.uk/pdbsum/1E4Y PDBsum 2ECK http://www.ebi.ac.uk/pdbsum/2ECK PDBsum 3HPQ http://www.ebi.ac.uk/pdbsum/3HPQ PDBsum 3HPR http://www.ebi.ac.uk/pdbsum/3HPR PDBsum 4AKE http://www.ebi.ac.uk/pdbsum/4AKE PDBsum 4X8H http://www.ebi.ac.uk/pdbsum/4X8H PDBsum 4X8L http://www.ebi.ac.uk/pdbsum/4X8L PDBsum 4X8M http://www.ebi.ac.uk/pdbsum/4X8M PDBsum 4X8O http://www.ebi.ac.uk/pdbsum/4X8O PRINTS PR00094 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00094 PROSITE PS00113 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00113 PSORT swissprot:KAD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:KAD_ECOLI PSORT-B swissprot:KAD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:KAD_ECOLI PSORT2 swissprot:KAD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:KAD_ECOLI Pfam PF05191 http://pfam.xfam.org/family/PF05191 Phobius swissprot:KAD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:KAD_ECOLI PhylomeDB P69441 http://phylomedb.org/?seqid=P69441 ProteinModelPortal P69441 http://www.proteinmodelportal.org/query/uniprot/P69441 PubMed 10398370 http://www.ncbi.nlm.nih.gov/pubmed/10398370 PubMed 1548697 http://www.ncbi.nlm.nih.gov/pubmed/1548697 PubMed 16302237 http://www.ncbi.nlm.nih.gov/pubmed/16302237 PubMed 166976 http://www.ncbi.nlm.nih.gov/pubmed/166976 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 19805185 http://www.ncbi.nlm.nih.gov/pubmed/19805185 PubMed 2051480 http://www.ncbi.nlm.nih.gov/pubmed/2051480 PubMed 2223776 http://www.ncbi.nlm.nih.gov/pubmed/2223776 PubMed 2844237 http://www.ncbi.nlm.nih.gov/pubmed/2844237 PubMed 2997739 http://www.ncbi.nlm.nih.gov/pubmed/2997739 PubMed 3299380 http://www.ncbi.nlm.nih.gov/pubmed/3299380 PubMed 6243627 http://www.ncbi.nlm.nih.gov/pubmed/6243627 PubMed 7937733 http://www.ncbi.nlm.nih.gov/pubmed/7937733 PubMed 8451239 http://www.ncbi.nlm.nih.gov/pubmed/8451239 PubMed 8805521 http://www.ncbi.nlm.nih.gov/pubmed/8805521 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 RefSeq NP_415007 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415007 RefSeq WP_001220233 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001220233 SMR P69441 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69441 STRING 511145.b0474 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0474&targetmode=cogs STRING COG0563 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0563&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SWISS-2DPAGE P69441 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P69441 TIGRFAMs TIGR01351 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01351 UniProtKB KAD_ECOLI http://www.uniprot.org/uniprot/KAD_ECOLI UniProtKB-AC P69441 http://www.uniprot.org/uniprot/P69441 charge swissprot:KAD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:KAD_ECOLI eggNOG COG0563 http://eggnogapi.embl.de/nog_data/html/tree/COG0563 eggNOG ENOG4105CC8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CC8 epestfind swissprot:KAD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:KAD_ECOLI garnier swissprot:KAD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:KAD_ECOLI helixturnhelix swissprot:KAD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:KAD_ECOLI hmoment swissprot:KAD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:KAD_ECOLI iep swissprot:KAD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:KAD_ECOLI inforesidue swissprot:KAD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:KAD_ECOLI octanol swissprot:KAD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:KAD_ECOLI pepcoil swissprot:KAD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:KAD_ECOLI pepdigest swissprot:KAD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:KAD_ECOLI pepinfo swissprot:KAD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:KAD_ECOLI pepnet swissprot:KAD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:KAD_ECOLI pepstats swissprot:KAD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:KAD_ECOLI pepwheel swissprot:KAD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:KAD_ECOLI pepwindow swissprot:KAD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:KAD_ECOLI sigcleave swissprot:KAD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:KAD_ECOLI ## Database ID URL or Descriptions # BioGrid 4259230 2 # EcoGene EG13039 ygeI # Organism YGEI_ECOLI Escherichia coli (strain K12) # PATRIC 48665146 VBIEscCol107702_2887 # PIR F65068 F65068 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGEI_ECOLI Uncharacterized protein YgeI # RefSeq NP_417330 NC_000913.3 # RefSeq WP_000184091 NZ_LN832404.1 BLAST swissprot:YGEI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGEI_ECOLI BioCyc ECOL316407:JW5456-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5456-MONOMER BioCyc EcoCyc:G7473-MONOMER http://biocyc.org/getid?id=EcoCyc:G7473-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 EchoBASE EB2854 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2854 EcoGene EG13039 http://www.ecogene.org/geneInfo.php?eg_id=EG13039 EnsemblBacteria AAC75892 http://www.ensemblgenomes.org/id/AAC75892 EnsemblBacteria AAC75892 http://www.ensemblgenomes.org/id/AAC75892 EnsemblBacteria BAE76922 http://www.ensemblgenomes.org/id/BAE76922 EnsemblBacteria BAE76922 http://www.ensemblgenomes.org/id/BAE76922 EnsemblBacteria BAE76922 http://www.ensemblgenomes.org/id/BAE76922 EnsemblBacteria b2853 http://www.ensemblgenomes.org/id/b2853 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947336 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947336 HOGENOM HOG000050884 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000050884&db=HOGENOM6 KEGG_Gene ecj:JW5456 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5456 KEGG_Gene eco:b2853 http://www.genome.jp/dbget-bin/www_bget?eco:b2853 OMA QNDMYSK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QNDMYSK PSORT swissprot:YGEI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGEI_ECOLI PSORT-B swissprot:YGEI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGEI_ECOLI PSORT2 swissprot:YGEI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGEI_ECOLI Phobius swissprot:YGEI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGEI_ECOLI ProteinModelPortal Q46789 http://www.proteinmodelportal.org/query/uniprot/Q46789 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417330 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417330 RefSeq WP_000184091 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000184091 STRING 511145.b2853 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2853&targetmode=cogs UniProtKB YGEI_ECOLI http://www.uniprot.org/uniprot/YGEI_ECOLI UniProtKB-AC Q46789 http://www.uniprot.org/uniprot/Q46789 charge swissprot:YGEI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGEI_ECOLI epestfind swissprot:YGEI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGEI_ECOLI garnier swissprot:YGEI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGEI_ECOLI helixturnhelix swissprot:YGEI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGEI_ECOLI hmoment swissprot:YGEI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGEI_ECOLI iep swissprot:YGEI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGEI_ECOLI inforesidue swissprot:YGEI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGEI_ECOLI octanol swissprot:YGEI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGEI_ECOLI pepcoil swissprot:YGEI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGEI_ECOLI pepdigest swissprot:YGEI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGEI_ECOLI pepinfo swissprot:YGEI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGEI_ECOLI pepnet swissprot:YGEI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGEI_ECOLI pepstats swissprot:YGEI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGEI_ECOLI pepwheel swissprot:YGEI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGEI_ECOLI pepwindow swissprot:YGEI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGEI_ECOLI sigcleave swissprot:YGEI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGEI_ECOLI ## Database ID URL or Descriptions # BioGrid 4260528 50 # DISRUPTION PHENOTYPE Deletion causes a mild cell chaining phenotype. {ECO:0000269|PubMed 19684127}. # DOMAIN DEDD_ECOLI The SPOR domain binds septal peptidoglycans and is required to target DedD to the septal ring. {ECO 0000255|HAMAP- Rule MF_02022, ECO 0000269|PubMed 19880599}. # EcoGene EG10218 dedD # FUNCTION DEDD_ECOLI Non-essential cell division protein that could be required for efficient cell constriction. {ECO 0000255|HAMAP- Rule MF_02022, ECO 0000269|PubMed 19684127}. # GO_component GO:0005887 integral component of plasma membrane; IEA:UniProtKB-HAMAP. # GO_component GO:0030428 cell septum; IDA:EcoCyc. # GO_component GO:0032153 cell division site; IDA:EcoCyc. # GO_function GO:0042834 peptidoglycan binding; IDA:EcoCyc. # GO_process GO:0032506 cytokinetic process; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0008150 biological_process # Gene3D 3.30.70.1070 -; 1. # HAMAP MF_02022 DedD # InterPro IPR007730 SPOR_dom # InterPro IPR032898 DedD # Organism DEDD_ECOLI Escherichia coli (strain K12) # PATRIC 32119999 VBIEscCol129921_2409 # PIR H65003 XMECDD # PROSITE PS51724 SPOR # Pfam PF05036 SPOR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Cell division protein DedD {ECO:0000255|HAMAP-Rule MF_02022, ECO:0000305} # RefSeq NP_416817 NC_000913.3 # RefSeq WP_000146992 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA23967.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the DedD family. {ECO:0000255|HAMAP- Rule MF_02022, ECO:0000305}. # SIMILARITY Contains 1 SPOR domain. {ECO:0000255|HAMAP- Rule MF_02022}. # SUBCELLULAR LOCATION DEDD_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_02022, ECO 0000305}; Single-pass membrane protein {ECO 0000255|HAMAP-Rule MF_02022}. Note=Localizes at the septal ring. {ECO 0000255|HAMAP-Rule MF_02022, ECO 0000269|PubMed 19684127, ECO 0000269|PubMed 19880599}. # SUPFAM SSF110997 SSF110997 # eggNOG COG3147 LUCA # eggNOG ENOG4108S3P Bacteria BLAST swissprot:DEDD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DEDD_ECOLI BioCyc ECOL316407:JW5378-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5378-MONOMER BioCyc EcoCyc:EG10218-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10218-MONOMER COG COG3147 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3147 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00811-09 http://dx.doi.org/10.1128/JB.00811-09 DOI 10.1128/JB.01244-09 http://dx.doi.org/10.1128/JB.01244-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M68934 http://www.ebi.ac.uk/ena/data/view/M68934 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0214 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0214 EcoGene EG10218 http://www.ecogene.org/geneInfo.php?eg_id=EG10218 EnsemblBacteria AAC75374 http://www.ensemblgenomes.org/id/AAC75374 EnsemblBacteria AAC75374 http://www.ensemblgenomes.org/id/AAC75374 EnsemblBacteria BAA16162 http://www.ensemblgenomes.org/id/BAA16162 EnsemblBacteria BAA16162 http://www.ensemblgenomes.org/id/BAA16162 EnsemblBacteria BAA16162 http://www.ensemblgenomes.org/id/BAA16162 EnsemblBacteria b2314 http://www.ensemblgenomes.org/id/b2314 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0030428 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030428 GO_component GO:0032153 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032153 GO_function GO:0042834 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042834 GO_process GO:0032506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032506 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.30.70.1070 http://www.cathdb.info/version/latest/superfamily/3.30.70.1070 GeneID 944971 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944971 HAMAP MF_02022 http://hamap.expasy.org/unirule/MF_02022 HOGENOM HOG000279501 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000279501&db=HOGENOM6 InterPro IPR007730 http://www.ebi.ac.uk/interpro/entry/IPR007730 InterPro IPR032898 http://www.ebi.ac.uk/interpro/entry/IPR032898 KEGG_Gene ecj:JW5378 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5378 KEGG_Gene eco:b2314 http://www.genome.jp/dbget-bin/www_bget?eco:b2314 KEGG_Orthology KO:K03749 http://www.genome.jp/dbget-bin/www_bget?KO:K03749 OMA PTRRGAN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PTRRGAN PROSITE PS51724 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51724 PSORT swissprot:DEDD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DEDD_ECOLI PSORT-B swissprot:DEDD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DEDD_ECOLI PSORT2 swissprot:DEDD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DEDD_ECOLI Pfam PF05036 http://pfam.xfam.org/family/PF05036 Phobius swissprot:DEDD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DEDD_ECOLI ProteinModelPortal P09549 http://www.proteinmodelportal.org/query/uniprot/P09549 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19684127 http://www.ncbi.nlm.nih.gov/pubmed/19684127 PubMed 19880599 http://www.ncbi.nlm.nih.gov/pubmed/19880599 PubMed 3040734 http://www.ncbi.nlm.nih.gov/pubmed/3040734 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416817 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416817 RefSeq WP_000146992 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000146992 STRING 511145.b2314 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2314&targetmode=cogs STRING COG3147 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3147&targetmode=cogs SUPFAM SSF110997 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF110997 UniProtKB DEDD_ECOLI http://www.uniprot.org/uniprot/DEDD_ECOLI UniProtKB-AC P09549 http://www.uniprot.org/uniprot/P09549 charge swissprot:DEDD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DEDD_ECOLI eggNOG COG3147 http://eggnogapi.embl.de/nog_data/html/tree/COG3147 eggNOG ENOG4108S3P http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108S3P epestfind swissprot:DEDD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DEDD_ECOLI garnier swissprot:DEDD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DEDD_ECOLI helixturnhelix swissprot:DEDD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DEDD_ECOLI hmoment swissprot:DEDD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DEDD_ECOLI iep swissprot:DEDD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DEDD_ECOLI inforesidue swissprot:DEDD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DEDD_ECOLI octanol swissprot:DEDD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DEDD_ECOLI pepcoil swissprot:DEDD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DEDD_ECOLI pepdigest swissprot:DEDD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DEDD_ECOLI pepinfo swissprot:DEDD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DEDD_ECOLI pepnet swissprot:DEDD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DEDD_ECOLI pepstats swissprot:DEDD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DEDD_ECOLI pepwheel swissprot:DEDD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DEDD_ECOLI pepwindow swissprot:DEDD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DEDD_ECOLI sigcleave swissprot:DEDD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DEDD_ECOLI ## Database ID URL or Descriptions # BioGrid 4261290 237 # EcoGene EG10883 rplW # FUNCTION RL23_ECOLI One of the early assembly proteins, it binds 23S rRNA; is essential for growth. One of the proteins that surround the polypeptide exit tunnel on the outside of the subunit. Acts as the docking site for trigger factor (PubMed 12226666) for Ffh binding to the ribosome (SRP54, PubMed 12756233 and PubMed 12702815) and to nascent polypeptide chains (PubMed 12756233). {ECO 0000269|PubMed 12226666, ECO 0000269|PubMed 12702815, ECO 0000269|PubMed 12756233, ECO 0000269|PubMed 3298242, ECO 0000269|PubMed 6170935}. # GO_component GO:0022625 cytosolic large ribosomal subunit; IDA:EcoCyc. # GO_function GO:0000166 nucleotide binding; IEA:InterPro. # GO_function GO:0003735 structural constituent of ribosome; IBA:GO_Central. # GO_function GO:0019843 rRNA binding; IEA:UniProtKB-HAMAP. # GO_process GO:0000027 ribosomal large subunit assembly; IBA:GO_Central. # GO_process GO:0006412 translation; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_function GO:0019843 rRNA binding # GOslim_process GO:0006412 translation # GOslim_process GO:0022618 ribonucleoprotein complex assembly # Gene3D 3.30.70.330 -; 1. # HAMAP MF_01369_B Ribosomal_L23_B # INTERACTION RL23_ECOLI P0A7W1 rpsE; NbExp=2; IntAct=EBI-542264, EBI-543949; # IntAct P0ADZ0 73 # InterPro IPR001014 Ribosomal_L23/L25_CS # InterPro IPR012677 Nucleotide-bd_a/b_plait # InterPro IPR012678 Ribosomal_L23/L15e_core_dom # InterPro IPR013025 Ribosomal_L25/23 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 M00179 Ribosome, archaea # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=11198.0; Method=MALDI; Range=1-100; Evidence={ECO:0000269|PubMed 10094780}; # Organism RL23_ECOLI Escherichia coli (strain K12) # PATRIC 32122068 VBIEscCol129921_3411 # PDB 1ML5 EM; 14.00 A; t=2-85 # PDB 2J28 EM; 8.00 A; T=1-99 # PDB 2RDO EM; 9.10 A; T=1-100 # PDB 2VRH EM; 19.00 A; B=1-100 # PDB 3BBX EM; 10.00 A; T=1-100 # PDB 3IY9 EM; 14.10 A; T=1-99 # PDB 3J45 EM; 9.50 A; T=1-100 # PDB 3J46 EM; 10.10 A; T=1-100 # PDB 3J5L EM; 6.60 A; T=1-93 # PDB 3J7Z EM; 3.90 A; T=1-100 # PDB 3J8G EM; 5.00 A; T=1-100 # PDB 3J9Y EM; 3.90 A; T=1-100 # PDB 3J9Z EM; 3.60 A; LR=1-100 # PDB 3JA1 EM; 3.60 A; LV=1-100 # PDB 3JBU EM; 3.64 A; t=1-100 # PDB 3JBV EM; 3.32 A; t=1-100 # PDB 3JCD EM; 3.70 A; T=1-100 # PDB 3JCE EM; 3.20 A; T=1-100 # PDB 3JCJ EM; 3.70 A; S=1-100 # PDB 3JCN EM; 4.60 A; T=1-100 # PDB 4CSU EM; 5.50 A; T=1-100 # PDB 4U1U X-ray; 2.95 A; BT/DT=1-93 # PDB 4U1V X-ray; 3.00 A; BT/DT=1-93 # PDB 4U20 X-ray; 2.90 A; BT/DT=1-93 # PDB 4U24 X-ray; 2.90 A; BT/DT=1-93 # PDB 4U25 X-ray; 2.90 A; BT/DT=1-93 # PDB 4U26 X-ray; 2.80 A; BT/DT=1-93 # PDB 4U27 X-ray; 2.80 A; BT/DT=1-93 # PDB 4UY8 EM; 3.80 A; T=1-93 # PDB 4V47 EM; 12.30 A; AR=1-100 # PDB 4V48 EM; 11.50 A; AR=1-100 # PDB 4V4H X-ray; 3.46 A; BT/DT=1-100 # PDB 4V4Q X-ray; 3.46 A; BT/DT=1-100 # PDB 4V4V EM; 15.00 A; BR=7-98 # PDB 4V4W EM; 15.00 A; BR=7-98 # PDB 4V50 X-ray; 3.22 A; BT/DT=1-100 # PDB 4V52 X-ray; 3.21 A; BT/DT=1-100 # PDB 4V53 X-ray; 3.54 A; BT/DT=1-100 # PDB 4V54 X-ray; 3.30 A; BT/DT=1-100 # PDB 4V55 X-ray; 4.00 A; BT/DT=1-100 # PDB 4V56 X-ray; 3.93 A; BT/DT=1-100 # PDB 4V57 X-ray; 3.50 A; BT/DT=1-100 # PDB 4V5B X-ray; 3.74 A; AT/CT=1-100 # PDB 4V5H EM; 5.80 A; BT=1-93 # PDB 4V5Y X-ray; 4.45 A; BT/DT=1-100 # PDB 4V64 X-ray; 3.50 A; BT/DT=1-100 # PDB 4V65 EM; 9.00 A; BM=1-99 # PDB 4V66 EM; 9.00 A; BM=1-99 # PDB 4V69 EM; 6.70 A; BT=1-93 # PDB 4V6C X-ray; 3.19 A; BT/DT=1-100 # PDB 4V6D X-ray; 3.81 A; BT/DT=1-100 # PDB 4V6E X-ray; 3.71 A; BT/DT=1-100 # PDB 4V6K EM; 8.25 A; AU=1-100 # PDB 4V6L EM; 13.20 A; BU=1-100 # PDB 4V6M EM; 7.10 A; BT=1-100 # PDB 4V6N EM; 12.10 A; AV=1-100 # PDB 4V6O EM; 14.70 A; BV=1-100 # PDB 4V6P EM; 13.50 A; BV=1-100 # PDB 4V6Q EM; 11.50 A; BV=1-100 # PDB 4V6R EM; 11.50 A; BV=1-100 # PDB 4V6S EM; 13.10 A; AV=1-100 # PDB 4V6T EM; 8.30 A; BT=1-93 # PDB 4V6V EM; 9.80 A; BX=1-100 # PDB 4V6Y EM; 12.00 A; BT=1-93 # PDB 4V6Z EM; 12.00 A; BT=1-93 # PDB 4V70 EM; 17.00 A; BT=1-93 # PDB 4V71 EM; 20.00 A; BT=1-93 # PDB 4V72 EM; 13.00 A; BT=1-93 # PDB 4V73 EM; 15.00 A; BT=1-93 # PDB 4V74 EM; 17.00 A; BT=1-93 # PDB 4V75 EM; 12.00 A; BT=1-93 # PDB 4V76 EM; 17.00 A; BT=1-93 # PDB 4V77 EM; 17.00 A; BT=1-93 # PDB 4V78 EM; 20.00 A; BT=1-93 # PDB 4V79 EM; 15.00 A; BT=1-93 # PDB 4V7A EM; 9.00 A; BT=1-93 # PDB 4V7B EM; 6.80 A; BT=1-100 # PDB 4V7C EM; 7.60 A; BV=1-100 # PDB 4V7D EM; 7.60 A; AW=1-100 # PDB 4V7I EM; 9.60 A; AT=1-100 # PDB 4V7S X-ray; 3.25 A; BT/DT=1-93 # PDB 4V7T X-ray; 3.19 A; BT/DT=1-93 # PDB 4V7U X-ray; 3.10 A; BT/DT=1-93 # PDB 4V7V X-ray; 3.29 A; BT/DT=1-93 # PDB 4V85 X-ray; 3.20 A; X=1-100 # PDB 4V89 X-ray; 3.70 A; BX=1-100 # PDB 4V9C X-ray; 3.30 A; BT/DT=1-100 # PDB 4V9D X-ray; 3.00 A; CT/DT=1-93 # PDB 4V9O X-ray; 2.90 A; AT/CT/ET/GT=1-100 # PDB 4V9P X-ray; 2.90 A; AT/CT/ET/GT=1-100 # PDB 4WF1 X-ray; 3.09 A; BT/DT=1-93 # PDB 4WOI X-ray; 3.00 A; BT/CT=1-100 # PDB 4WWW X-ray; 3.10 A; RT/YT=1-93 # PDB 4YBB X-ray; 2.10 A; CU/DU=1-93 # PDB 5ADY EM; 4.50 A; T=1-100 # PDB 5AFI EM; 2.90 A; T=1-100 # PDB 5AKA EM; 5.70 A; T=1-100 # PDB 5GAD EM; 3.70 A; U=1-100 # PDB 5GAE EM; 3.33 A; U=1-100 # PDB 5GAF EM; 4.30 A; U=2-96 # PDB 5GAG EM; 3.80 A; U=1-100 # PDB 5GAH EM; 3.80 A; U=1-100 # PDB 5IQR EM; 3.00 A; T=1-100 # PDB 5IT8 X-ray; 3.12 A; CU/DU=1-93 # PDB 5J5B X-ray; 2.80 A; CU/DU=1-93 # PDB 5J7L X-ray; 3.00 A; CU/DU=1-93 # PDB 5J88 X-ray; 3.32 A; CU/DU=1-100 # PDB 5J8A X-ray; 3.10 A; CU/DU=1-93 # PDB 5J91 X-ray; 2.96 A; CU/DU=1-93 # PDB 5JC9 X-ray; 3.03 A; CU/DU=1-93 # PDB 5JTE EM; 3.60 A; BT=1-100 # PDB 5JU8 EM; 3.60 A; BT=1-100 # PDB 5KCR EM; 3.60 A; 1X=1-100 # PDB 5KCS EM; 3.90 A; 1X=1-100 # PDB 5KPS EM; 3.90 A; T=1-100 # PDB 5KPV EM; 4.10 A; S=1-100 # PDB 5KPW EM; 3.90 A; S=1-100 # PDB 5KPX EM; 3.90 A; S=1-100 # PDB 5L3P EM; 3.70 A; X=1-100 # PIR A65125 R5EC23 # PROSITE PS00050 RIBOSOMAL_L23 # Pfam PF00276 Ribosomal_L23 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 50S ribosomal protein L23 {ECO:0000255|HAMAP-Rule MF_01369} # RefSeq NP_417777 NC_000913.3 # RefSeq WP_000617544 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein L23P family. {ECO:0000255|HAMAP-Rule MF_01369}. # SUBUNIT RL23_ECOLI Part of the 50S ribosomal subunit. Contacts protein L29 and trigger factor. Might also contact SecE and probably does contact SecG and SecY when the SecYEG translocation complex is docked with the ribosome. {ECO 0000269|PubMed 12226666, ECO 0000269|PubMed 12756233, ECO 0000269|PubMed 16292303, ECO 0000269|PubMed 21499241, ECO 0000269|PubMed 2665813}. # SUPFAM SSF54189 SSF54189 # eggNOG COG0089 LUCA # eggNOG ENOG41080KG Bacteria BLAST swissprot:RL23_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RL23_ECOLI BioCyc ECOL316407:JW3280-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3280-MONOMER BioCyc EcoCyc:EG10883-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10883-MONOMER BioCyc MetaCyc:EG10883-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10883-MONOMER COG COG0089 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0089 DIP DIP-35972N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35972N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1016/0014-5793(79)81181-3 http://dx.doi.org/10.1016/0014-5793(79)81181-3 DOI 10.1016/S0092-8674(03)00427-6 http://dx.doi.org/10.1016/S0092-8674(03)00427-6 DOI 10.1016/j.celrep.2014.09.011 http://dx.doi.org/10.1016/j.celrep.2014.09.011 DOI 10.1021/bi00435a071 http://dx.doi.org/10.1021/bi00435a071 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature01047 http://dx.doi.org/10.1038/nature01047 DOI 10.1038/nature04133 http://dx.doi.org/10.1038/nature04133 DOI 10.1038/nsmb.2026 http://dx.doi.org/10.1038/nsmb.2026 DOI 10.1083/jcb.200302130 http://dx.doi.org/10.1083/jcb.200302130 DOI 10.1093/nar/13.12.4521 http://dx.doi.org/10.1093/nar/13.12.4521 DOI 10.1093/nar/9.17.4285 http://dx.doi.org/10.1093/nar/9.17.4285 DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1261/rna.2196403 http://dx.doi.org/10.1261/rna.2196403 DOI 10.1371/journal.pbio.1001866 http://dx.doi.org/10.1371/journal.pbio.1001866 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X02613 http://www.ebi.ac.uk/ena/data/view/X02613 EchoBASE EB0876 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0876 EcoGene EG10883 http://www.ecogene.org/geneInfo.php?eg_id=EG10883 EnsemblBacteria AAC76343 http://www.ensemblgenomes.org/id/AAC76343 EnsemblBacteria AAC76343 http://www.ensemblgenomes.org/id/AAC76343 EnsemblBacteria BAE77973 http://www.ensemblgenomes.org/id/BAE77973 EnsemblBacteria BAE77973 http://www.ensemblgenomes.org/id/BAE77973 EnsemblBacteria BAE77973 http://www.ensemblgenomes.org/id/BAE77973 EnsemblBacteria b3318 http://www.ensemblgenomes.org/id/b3318 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0022625 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022625 GO_function GO:0000166 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000166 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GO_process GO:0000027 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000027 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_process GO:0022618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022618 Gene3D 3.30.70.330 http://www.cathdb.info/version/latest/superfamily/3.30.70.330 GeneID 947819 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947819 HAMAP MF_01369_B http://hamap.expasy.org/unirule/MF_01369_B HOGENOM HOG000231364 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231364&db=HOGENOM6 InParanoid P0ADZ0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADZ0 IntAct P0ADZ0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADZ0* InterPro IPR001014 http://www.ebi.ac.uk/interpro/entry/IPR001014 InterPro IPR012677 http://www.ebi.ac.uk/interpro/entry/IPR012677 InterPro IPR012678 http://www.ebi.ac.uk/interpro/entry/IPR012678 InterPro IPR013025 http://www.ebi.ac.uk/interpro/entry/IPR013025 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW3280 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3280 KEGG_Gene eco:b3318 http://www.genome.jp/dbget-bin/www_bget?eco:b3318 KEGG_Orthology KO:K02892 http://www.genome.jp/dbget-bin/www_bget?KO:K02892 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 MINT MINT-1225825 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1225825 OMA KGIVGRQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KGIVGRQ PDB 1ML5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ML5 PDB 2J28 http://www.ebi.ac.uk/pdbe-srv/view/entry/2J28 PDB 2RDO http://www.ebi.ac.uk/pdbe-srv/view/entry/2RDO PDB 2VRH http://www.ebi.ac.uk/pdbe-srv/view/entry/2VRH PDB 3BBX http://www.ebi.ac.uk/pdbe-srv/view/entry/3BBX PDB 3IY9 http://www.ebi.ac.uk/pdbe-srv/view/entry/3IY9 PDB 3J45 http://www.ebi.ac.uk/pdbe-srv/view/entry/3J45 PDB 3J46 http://www.ebi.ac.uk/pdbe-srv/view/entry/3J46 PDB 3J5L http://www.ebi.ac.uk/pdbe-srv/view/entry/3J5L PDB 3J7Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J7Z PDB 3J8G http://www.ebi.ac.uk/pdbe-srv/view/entry/3J8G PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 4CSU http://www.ebi.ac.uk/pdbe-srv/view/entry/4CSU PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4UY8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4UY8 PDB 4V47 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V47 PDB 4V48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V48 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5ADY http://www.ebi.ac.uk/pdbe-srv/view/entry/5ADY PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5AKA http://www.ebi.ac.uk/pdbe-srv/view/entry/5AKA PDB 5GAD http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAD PDB 5GAE http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAE PDB 5GAF http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAF PDB 5GAG http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAG PDB 5GAH http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAH PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 1ML5 http://www.ebi.ac.uk/pdbsum/1ML5 PDBsum 2J28 http://www.ebi.ac.uk/pdbsum/2J28 PDBsum 2RDO http://www.ebi.ac.uk/pdbsum/2RDO PDBsum 2VRH http://www.ebi.ac.uk/pdbsum/2VRH PDBsum 3BBX http://www.ebi.ac.uk/pdbsum/3BBX PDBsum 3IY9 http://www.ebi.ac.uk/pdbsum/3IY9 PDBsum 3J45 http://www.ebi.ac.uk/pdbsum/3J45 PDBsum 3J46 http://www.ebi.ac.uk/pdbsum/3J46 PDBsum 3J5L http://www.ebi.ac.uk/pdbsum/3J5L PDBsum 3J7Z http://www.ebi.ac.uk/pdbsum/3J7Z PDBsum 3J8G http://www.ebi.ac.uk/pdbsum/3J8G PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 4CSU http://www.ebi.ac.uk/pdbsum/4CSU PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4UY8 http://www.ebi.ac.uk/pdbsum/4UY8 PDBsum 4V47 http://www.ebi.ac.uk/pdbsum/4V47 PDBsum 4V48 http://www.ebi.ac.uk/pdbsum/4V48 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5ADY http://www.ebi.ac.uk/pdbsum/5ADY PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5AKA http://www.ebi.ac.uk/pdbsum/5AKA PDBsum 5GAD http://www.ebi.ac.uk/pdbsum/5GAD PDBsum 5GAE http://www.ebi.ac.uk/pdbsum/5GAE PDBsum 5GAF http://www.ebi.ac.uk/pdbsum/5GAF PDBsum 5GAG http://www.ebi.ac.uk/pdbsum/5GAG PDBsum 5GAH http://www.ebi.ac.uk/pdbsum/5GAH PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PROSITE PS00050 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00050 PSORT swissprot:RL23_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RL23_ECOLI PSORT-B swissprot:RL23_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RL23_ECOLI PSORT2 swissprot:RL23_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RL23_ECOLI Pfam PF00276 http://pfam.xfam.org/family/PF00276 Phobius swissprot:RL23_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RL23_ECOLI PhylomeDB P0ADZ0 http://phylomedb.org/?seqid=P0ADZ0 ProteinModelPortal P0ADZ0 http://www.proteinmodelportal.org/query/uniprot/P0ADZ0 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 12226666 http://www.ncbi.nlm.nih.gov/pubmed/12226666 PubMed 12702815 http://www.ncbi.nlm.nih.gov/pubmed/12702815 PubMed 12756233 http://www.ncbi.nlm.nih.gov/pubmed/12756233 PubMed 12809609 http://www.ncbi.nlm.nih.gov/pubmed/12809609 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16292303 http://www.ncbi.nlm.nih.gov/pubmed/16292303 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21499241 http://www.ncbi.nlm.nih.gov/pubmed/21499241 PubMed 24844575 http://www.ncbi.nlm.nih.gov/pubmed/24844575 PubMed 25310980 http://www.ncbi.nlm.nih.gov/pubmed/25310980 PubMed 2665813 http://www.ncbi.nlm.nih.gov/pubmed/2665813 PubMed 3298242 http://www.ncbi.nlm.nih.gov/pubmed/3298242 PubMed 3892488 http://www.ncbi.nlm.nih.gov/pubmed/3892488 PubMed 391594 http://www.ncbi.nlm.nih.gov/pubmed/391594 PubMed 6170935 http://www.ncbi.nlm.nih.gov/pubmed/6170935 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417777 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417777 RefSeq WP_000617544 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000617544 SMR P0ADZ0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADZ0 STRING 511145.b3318 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3318&targetmode=cogs STRING COG0089 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0089&targetmode=cogs SUPFAM SSF54189 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54189 UniProtKB RL23_ECOLI http://www.uniprot.org/uniprot/RL23_ECOLI UniProtKB-AC P0ADZ0 http://www.uniprot.org/uniprot/P0ADZ0 charge swissprot:RL23_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RL23_ECOLI eggNOG COG0089 http://eggnogapi.embl.de/nog_data/html/tree/COG0089 eggNOG ENOG41080KG http://eggnogapi.embl.de/nog_data/html/tree/ENOG41080KG epestfind swissprot:RL23_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RL23_ECOLI garnier swissprot:RL23_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RL23_ECOLI helixturnhelix swissprot:RL23_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RL23_ECOLI hmoment swissprot:RL23_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RL23_ECOLI iep swissprot:RL23_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RL23_ECOLI inforesidue swissprot:RL23_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RL23_ECOLI octanol swissprot:RL23_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RL23_ECOLI pepcoil swissprot:RL23_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RL23_ECOLI pepdigest swissprot:RL23_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RL23_ECOLI pepinfo swissprot:RL23_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RL23_ECOLI pepnet swissprot:RL23_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RL23_ECOLI pepstats swissprot:RL23_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RL23_ECOLI pepwheel swissprot:RL23_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RL23_ECOLI pepwindow swissprot:RL23_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RL23_ECOLI sigcleave swissprot:RL23_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RL23_ECOLI ## Database ID URL or Descriptions # AltName AMPH_ECOLI DD-alanine-endopeptidase # AltName AMPH_ECOLI DD-carboxypeptidase # AltName AMPH_ECOLI Penicillin-binding protein AmpH # BIOPHYSICOCHEMICAL PROPERTIES AMPH_ECOLI Kinetic parameters KM=102 uM for D45 (at 37 degrees Celsius and pH 7.3) {ECO 0000269|PubMed 22001512}; KM=134 uM for D44 (at 37 degrees Celsius and pH 7.3) {ECO 0000269|PubMed 22001512}; KM=225 uM for M5 (at 37 degrees Celsius and pH 7.5) {ECO 0000269|PubMed 22001512}; Vmax=4.98 nmol/min/ug enzyme with M5 as substrate (at 37 degrees Celsius and pH 7.5) {ECO 0000269|PubMed 22001512}; Vmax=162 nmol/min/ug enzyme with D44 as substrate (at 37 degrees Celsius and pH 7.3) {ECO 0000269|PubMed 22001512}; Vmax=174 nmol/min/ug enzyme with D45 as substrate (at 37 degrees Celsius and pH 7.3) {ECO 0000269|PubMed 22001512}; # BioGrid 4259482 219 # DISRUPTION PHENOTYPE Disruption is viable and exhibits no overt growth defects, but produces morphologically aberrant cells, particularly in cell filaments induced by aztreonam. {ECO:0000269|PubMed 9324260}. # ENZYME REGULATION Inhibited by cefmetazole. {ECO:0000269|PubMed 22001512}. # EcoGene EG12867 ampH # FUNCTION AMPH_ECOLI Hydrolyzes the cross-linked dimers tetrapentapeptide (D45) and tetratetrapeptide (D44). Removes the terminal D-alanine from muropeptides and disaccharide pentapeptide M5 with a C- terminal D-Ala-D-Ala dipeptide. Associated with recycling and remodeling of peptidoglycan (PG). Also displays a low beta- lactamase activity. {ECO 0000269|PubMed 22001512}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_function GO:0004175 endopeptidase activity; IDA:UniProtKB. # GO_function GO:0004180 carboxypeptidase activity; IDA:UniProtKB. # GO_function GO:0008658 penicillin binding; IDA:EcoCyc. # GO_process GO:0008360 regulation of cell shape; IMP:UniProtKB. # GO_process GO:0009253 peptidoglycan catabolic process; IMP:UniProtKB. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 3.40.710.10 -; 1. # InterPro IPR001466 Beta-lactam-related # InterPro IPR012338 Beta-lactam/transpept-like # MASS SPECTROMETRY Mass=41860; Method=MALDI; Range=23-385; Evidence={ECO:0000269|PubMed 22001512}; # Organism AMPH_ECOLI Escherichia coli (strain K12) # PATRIC 32115891 VBIEscCol129921_0387 # PIR H64765 H64765 # Pfam PF00144 Beta-lactamase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AMPH_ECOLI D-alanyl-D-alanine-carboxypeptidase/endopeptidase AmpH # RefSeq NP_414910 NC_000913.3 # RefSeq WP_000830741 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18099.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the beta-lactamase family. {ECO 0000305}. # SUBCELLULAR LOCATION AMPH_ECOLI Cell inner membrane {ECO 0000269|PubMed 22001512}. # SUPFAM SSF56601 SSF56601 # eggNOG COG1680 LUCA # eggNOG ENOG4107R6D Bacteria BLAST swissprot:AMPH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AMPH_ECOLI BioCyc ECOL316407:JW5052-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5052-MONOMER BioCyc EcoCyc:EG12867-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12867-MONOMER BioCyc MetaCyc:EG12867-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12867-MONOMER DIP DIP-47910N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47910N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.05764-11 http://dx.doi.org/10.1128/JB.05764-11 EC_number EC:3.4.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.4.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EMBL X54153 http://www.ebi.ac.uk/ena/data/view/X54153 ENZYME 3.4.-.- http://enzyme.expasy.org/EC/3.4.-.- EchoBASE EB2708 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2708 EcoGene EG12867 http://www.ecogene.org/geneInfo.php?eg_id=EG12867 EnsemblBacteria AAC73479 http://www.ensemblgenomes.org/id/AAC73479 EnsemblBacteria AAC73479 http://www.ensemblgenomes.org/id/AAC73479 EnsemblBacteria BAE76157 http://www.ensemblgenomes.org/id/BAE76157 EnsemblBacteria BAE76157 http://www.ensemblgenomes.org/id/BAE76157 EnsemblBacteria BAE76157 http://www.ensemblgenomes.org/id/BAE76157 EnsemblBacteria b0376 http://www.ensemblgenomes.org/id/b0376 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0004175 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004175 GO_function GO:0004180 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004180 GO_function GO:0008658 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008658 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0009253 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009253 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 3.40.710.10 http://www.cathdb.info/version/latest/superfamily/3.40.710.10 GeneID 946904 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946904 HOGENOM HOG000117477 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117477&db=HOGENOM6 InParanoid P0AD70 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AD70 IntAct P0AD70 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AD70* IntEnz 3.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4 InterPro IPR001466 http://www.ebi.ac.uk/interpro/entry/IPR001466 InterPro IPR012338 http://www.ebi.ac.uk/interpro/entry/IPR012338 KEGG_Gene ecj:JW5052 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5052 KEGG_Gene eco:b0376 http://www.genome.jp/dbget-bin/www_bget?eco:b0376 OMA PASANAY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PASANAY PSORT swissprot:AMPH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AMPH_ECOLI PSORT-B swissprot:AMPH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AMPH_ECOLI PSORT2 swissprot:AMPH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AMPH_ECOLI Pfam PF00144 http://pfam.xfam.org/family/PF00144 Phobius swissprot:AMPH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AMPH_ECOLI PhylomeDB P0AD70 http://phylomedb.org/?seqid=P0AD70 ProteinModelPortal P0AD70 http://www.proteinmodelportal.org/query/uniprot/P0AD70 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1840583 http://www.ncbi.nlm.nih.gov/pubmed/1840583 PubMed 22001512 http://www.ncbi.nlm.nih.gov/pubmed/22001512 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9324260 http://www.ncbi.nlm.nih.gov/pubmed/9324260 RefSeq NP_414910 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414910 RefSeq WP_000830741 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000830741 SMR P0AD70 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AD70 STRING 511145.b0376 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0376&targetmode=cogs SUPFAM SSF56601 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56601 UniProtKB AMPH_ECOLI http://www.uniprot.org/uniprot/AMPH_ECOLI UniProtKB-AC P0AD70 http://www.uniprot.org/uniprot/P0AD70 charge swissprot:AMPH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AMPH_ECOLI eggNOG COG1680 http://eggnogapi.embl.de/nog_data/html/tree/COG1680 eggNOG ENOG4107R6D http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107R6D epestfind swissprot:AMPH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AMPH_ECOLI garnier swissprot:AMPH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AMPH_ECOLI helixturnhelix swissprot:AMPH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AMPH_ECOLI hmoment swissprot:AMPH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AMPH_ECOLI iep swissprot:AMPH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AMPH_ECOLI inforesidue swissprot:AMPH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AMPH_ECOLI octanol swissprot:AMPH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AMPH_ECOLI pepcoil swissprot:AMPH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AMPH_ECOLI pepdigest swissprot:AMPH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AMPH_ECOLI pepinfo swissprot:AMPH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AMPH_ECOLI pepnet swissprot:AMPH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AMPH_ECOLI pepstats swissprot:AMPH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AMPH_ECOLI pepwheel swissprot:AMPH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AMPH_ECOLI pepwindow swissprot:AMPH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AMPH_ECOLI sigcleave swissprot:AMPH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AMPH_ECOLI ## Database ID URL or Descriptions # AltName INSB3_ECOLI IS1c # EcoGene EG40002 insB3 # FUNCTION INSB3_ECOLI Absolutely required for transposition of IS1. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # InterPro IPR005063 Transposase_27 # Organism INSB3_ECOLI Escherichia coli (strain K12) # PIR JN0137 IEECA1 # Pfam PF03400 DDE_Tnp_IS1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSB3_ECOLI Insertion element IS1 3 protein InsB # RefSeq NP_414798 NC_000913.3 # RefSeq NP_414808 NC_000913.3 # RefSeq WP_001119292 NZ_LN832404.1 # SIMILARITY Belongs to the transposase 27 family. {ECO 0000305}. # eggNOG COG1662 LUCA # eggNOG ENOG4108MBK Bacteria BLAST swissprot:INSB3_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSB3_ECOLI COG COG1662 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1662 DOI 10.1016/0378-1119(91)90096-T http://dx.doi.org/10.1016/0378-1119(91)90096-T DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EMBL X52535 http://www.ebi.ac.uk/ena/data/view/X52535 EchoBASE EB4707 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4707 EcoGene EG40002 http://www.ecogene.org/geneInfo.php?eg_id=EG40002 EnsemblBacteria AAC73377 http://www.ensemblgenomes.org/id/AAC73377 EnsemblBacteria AAC73377 http://www.ensemblgenomes.org/id/AAC73377 EnsemblBacteria BAE76058 http://www.ensemblgenomes.org/id/BAE76058 EnsemblBacteria BAE76058 http://www.ensemblgenomes.org/id/BAE76058 EnsemblBacteria BAE76058 http://www.ensemblgenomes.org/id/BAE76058 EnsemblBacteria b0274 http://www.ensemblgenomes.org/id/b0274 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GeneID 944950 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944950 GeneID 947698 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947698 HOGENOM HOG000036821 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000036821&db=HOGENOM6 InParanoid P0CF27 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CF27 InterPro IPR005063 http://www.ebi.ac.uk/interpro/entry/IPR005063 KEGG_Gene ecj:JW0268 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0268 KEGG_Gene eco:b0264 http://www.genome.jp/dbget-bin/www_bget?eco:b0264 KEGG_Gene eco:b0274 http://www.genome.jp/dbget-bin/www_bget?eco:b0274 KEGG_Orthology KO:K07480 http://www.genome.jp/dbget-bin/www_bget?KO:K07480 PSORT swissprot:INSB3_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSB3_ECOLI PSORT-B swissprot:INSB3_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSB3_ECOLI PSORT2 swissprot:INSB3_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSB3_ECOLI Pfam PF03400 http://pfam.xfam.org/family/PF03400 Phobius swissprot:INSB3_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSB3_ECOLI PhylomeDB P0CF27 http://phylomedb.org/?seqid=P0CF27 ProteinModelPortal P0CF27 http://www.proteinmodelportal.org/query/uniprot/P0CF27 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1849492 http://www.ncbi.nlm.nih.gov/pubmed/1849492 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414798 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414798 RefSeq NP_414808 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414808 RefSeq WP_001119292 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001119292 STRING 511145.b0274 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0274&targetmode=cogs STRING COG1662 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1662&targetmode=cogs UniProtKB INSB3_ECOLI http://www.uniprot.org/uniprot/INSB3_ECOLI UniProtKB-AC P0CF27 http://www.uniprot.org/uniprot/P0CF27 charge swissprot:INSB3_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSB3_ECOLI eggNOG COG1662 http://eggnogapi.embl.de/nog_data/html/tree/COG1662 eggNOG ENOG4108MBK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MBK epestfind swissprot:INSB3_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSB3_ECOLI garnier swissprot:INSB3_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSB3_ECOLI helixturnhelix swissprot:INSB3_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSB3_ECOLI hmoment swissprot:INSB3_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSB3_ECOLI iep swissprot:INSB3_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSB3_ECOLI inforesidue swissprot:INSB3_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSB3_ECOLI octanol swissprot:INSB3_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSB3_ECOLI pepcoil swissprot:INSB3_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSB3_ECOLI pepdigest swissprot:INSB3_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSB3_ECOLI pepinfo swissprot:INSB3_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSB3_ECOLI pepnet swissprot:INSB3_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSB3_ECOLI pepstats swissprot:INSB3_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSB3_ECOLI pepwheel swissprot:INSB3_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSB3_ECOLI pepwindow swissprot:INSB3_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSB3_ECOLI sigcleave swissprot:INSB3_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSB3_ECOLI ## Database ID URL or Descriptions # AltName CRFC_ECOLI Clamp-binding sister replication fork colocalization protein # BioGrid 4263087 5 # DISRUPTION PHENOTYPE A small proportion of anucleate cells, disrupts nucleoid positioning, leads to premature separation of sister replication forks. {ECO:0000269|PubMed 23994470}. # EcoGene EG11210 crfC # FUNCTION CRFC_ECOLI Important for the colocalization of sister nascent DNA strands after replication fork passage during DNA replication, and for positioning and subsequent partitioning of sister chromosomes. Does not have GTPase activity on its own. {ECO 0000269|PubMed 23994470}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0005525 GTP binding; IEA:InterPro. # GO_process GO:0006260 DNA replication; IEA:UniProtKB-KW. # GO_process GO:0007059 chromosome segregation; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0007059 chromosome segregation # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.300 -; 2. # IntAct P0DM85 12 # InterPro IPR022812 Dynamin_SF # InterPro IPR027417 P-loop_NTPase # InterPro IPR030381 G_DYNAMIN_dom # Organism CRFC_ECOLI Escherichia coli (strain K12) # PIR S56337 S56337 # PROSITE PS51718 G_DYNAMIN_2 # Pfam PF00350 Dynamin_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CRFC_ECOLI Clamp-binding protein CrfC # RefSeq NP_418533 NC_000913.3 # RefSeq WP_000288603 NZ_LN832404.1 # SIMILARITY Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. {ECO 0000305}. # SIMILARITY Contains 1 dynamin-type G (guanine nucleotide-binding) domain. {ECO 0000305}. # SUBCELLULAR LOCATION CRFC_ECOLI Cytoplasm {ECO 0000269|PubMed 23994470}. Note=About half the protein co-localizes with beta sliding clamp (DnaN) at midcell, the rest without clamp in quarter-cell positions when chromosomes are condensed during DNA replication. # SUBUNIT Forms homooligomers. Binds to the beta sliding clamp processivity factor (DnaN) in the presence and absence of DNA, may bind to the clamp itself as homodimers or trimers. Homooligomers may be able to bind more than 1 clamp complex. {ECO:0000269|PubMed 23994470}. # SUPFAM SSF52540 SSF52540; 2 # eggNOG COG0699 LUCA # eggNOG ENOG4108F5E Bacteria BLAST swissprot:CRFC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CRFC_ECOLI DOI 10.1016/j.celrep.2013.07.040 http://dx.doi.org/10.1016/j.celrep.2013.07.040 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB1195 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1195 EcoGene EG11210 http://www.ecogene.org/geneInfo.php?eg_id=EG11210 EnsemblBacteria AAC77070 http://www.ensemblgenomes.org/id/AAC77070 EnsemblBacteria AAC77070 http://www.ensemblgenomes.org/id/AAC77070 EnsemblBacteria BAE78111 http://www.ensemblgenomes.org/id/BAE78111 EnsemblBacteria BAE78111 http://www.ensemblgenomes.org/id/BAE78111 EnsemblBacteria BAE78111 http://www.ensemblgenomes.org/id/BAE78111 EnsemblBacteria b4109 http://www.ensemblgenomes.org/id/b4109 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_process GO:0006260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260 GO_process GO:0007059 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007059 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0007059 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007059 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948620 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948620 IntAct P0DM85 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0DM85* InterPro IPR022812 http://www.ebi.ac.uk/interpro/entry/IPR022812 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR030381 http://www.ebi.ac.uk/interpro/entry/IPR030381 KEGG_Gene ecj:JW4070 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4070 KEGG_Gene eco:b4109 http://www.genome.jp/dbget-bin/www_bget?eco:b4109 OMA TAGMATF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TAGMATF PROSITE PS51718 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51718 PSORT swissprot:CRFC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CRFC_ECOLI PSORT-B swissprot:CRFC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CRFC_ECOLI PSORT2 swissprot:CRFC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CRFC_ECOLI Pfam PF00350 http://pfam.xfam.org/family/PF00350 Phobius swissprot:CRFC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CRFC_ECOLI ProteinModelPortal P0DM85 http://www.proteinmodelportal.org/query/uniprot/P0DM85 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 23994470 http://www.ncbi.nlm.nih.gov/pubmed/23994470 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418533 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418533 RefSeq WP_000288603 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000288603 SMR P0DM85 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0DM85 STRING 511145.b4109 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4109&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB CRFC_ECOLI http://www.uniprot.org/uniprot/CRFC_ECOLI UniProtKB-AC P0DM85 http://www.uniprot.org/uniprot/P0DM85 charge swissprot:CRFC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CRFC_ECOLI eggNOG COG0699 http://eggnogapi.embl.de/nog_data/html/tree/COG0699 eggNOG ENOG4108F5E http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108F5E epestfind swissprot:CRFC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CRFC_ECOLI garnier swissprot:CRFC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CRFC_ECOLI helixturnhelix swissprot:CRFC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CRFC_ECOLI hmoment swissprot:CRFC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CRFC_ECOLI iep swissprot:CRFC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CRFC_ECOLI inforesidue swissprot:CRFC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CRFC_ECOLI octanol swissprot:CRFC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CRFC_ECOLI pepcoil swissprot:CRFC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CRFC_ECOLI pepdigest swissprot:CRFC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CRFC_ECOLI pepinfo swissprot:CRFC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CRFC_ECOLI pepnet swissprot:CRFC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CRFC_ECOLI pepstats swissprot:CRFC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CRFC_ECOLI pepwheel swissprot:CRFC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CRFC_ECOLI pepwindow swissprot:CRFC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CRFC_ECOLI sigcleave swissprot:CRFC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CRFC_ECOLI ## Database ID URL or Descriptions # BioGrid 4259181 309 # EcoGene EG14156 yfeO # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005247 voltage-gated chloride channel activity; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # Gene3D 1.10.3080.10 -; 1. # HAMAP MF_01115 CLC_YfeO # InterPro IPR001807 Cl-channel_volt-gated # InterPro IPR014743 Cl-channel_core # InterPro IPR022969 Chloride_channel_YfeO # Organism YFEO_ECOLI Escherichia coli (strain K12) # PATRIC 32120157 VBIEscCol129921_2487 # PIR B65013 B65013 # PRINTS PR00762 CLCHANNEL # Pfam PF00654 Voltage_CLC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFEO_ECOLI Putative ion-transport protein YfeO # RefSeq NP_416890 NC_000913.3 # RefSeq WP_000903148 NZ_LN832404.1 # SIMILARITY Belongs to the chloride channel (TC 2.A.49) family. {ECO 0000305}. # SUBCELLULAR LOCATION YFEO_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # SUPFAM SSF81340 SSF81340 # eggNOG COG0038 LUCA # eggNOG ENOG4105VCT Bacteria BLAST swissprot:YFEO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFEO_ECOLI BioCyc ECOL316407:JW2386-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2386-MONOMER BioCyc EcoCyc:G7251-MONOMER http://biocyc.org/getid?id=EcoCyc:G7251-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3908 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3908 EcoGene EG14156 http://www.ecogene.org/geneInfo.php?eg_id=EG14156 EnsemblBacteria AAC75448 http://www.ensemblgenomes.org/id/AAC75448 EnsemblBacteria AAC75448 http://www.ensemblgenomes.org/id/AAC75448 EnsemblBacteria BAE76708 http://www.ensemblgenomes.org/id/BAE76708 EnsemblBacteria BAE76708 http://www.ensemblgenomes.org/id/BAE76708 EnsemblBacteria BAE76708 http://www.ensemblgenomes.org/id/BAE76708 EnsemblBacteria b2389 http://www.ensemblgenomes.org/id/b2389 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005247 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005247 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 Gene3D 1.10.3080.10 http://www.cathdb.info/version/latest/superfamily/1.10.3080.10 GeneID 946854 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946854 HAMAP MF_01115 http://hamap.expasy.org/unirule/MF_01115 HOGENOM HOG000267985 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267985&db=HOGENOM6 InParanoid P67729 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P67729 InterPro IPR001807 http://www.ebi.ac.uk/interpro/entry/IPR001807 InterPro IPR014743 http://www.ebi.ac.uk/interpro/entry/IPR014743 InterPro IPR022969 http://www.ebi.ac.uk/interpro/entry/IPR022969 KEGG_Gene ecj:JW2386 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2386 KEGG_Gene eco:b2389 http://www.genome.jp/dbget-bin/www_bget?eco:b2389 OMA MQQLAFS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MQQLAFS PRINTS PR00762 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00762 PSORT swissprot:YFEO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFEO_ECOLI PSORT-B swissprot:YFEO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFEO_ECOLI PSORT2 swissprot:YFEO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFEO_ECOLI Pfam PF00654 http://pfam.xfam.org/family/PF00654 Phobius swissprot:YFEO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFEO_ECOLI ProteinModelPortal P67729 http://www.proteinmodelportal.org/query/uniprot/P67729 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416890 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416890 RefSeq WP_000903148 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000903148 STRING 511145.b2389 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2389&targetmode=cogs SUPFAM SSF81340 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81340 UniProtKB YFEO_ECOLI http://www.uniprot.org/uniprot/YFEO_ECOLI UniProtKB-AC P67729 http://www.uniprot.org/uniprot/P67729 charge swissprot:YFEO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFEO_ECOLI eggNOG COG0038 http://eggnogapi.embl.de/nog_data/html/tree/COG0038 eggNOG ENOG4105VCT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VCT epestfind swissprot:YFEO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFEO_ECOLI garnier swissprot:YFEO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFEO_ECOLI helixturnhelix swissprot:YFEO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFEO_ECOLI hmoment swissprot:YFEO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFEO_ECOLI iep swissprot:YFEO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFEO_ECOLI inforesidue swissprot:YFEO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFEO_ECOLI octanol swissprot:YFEO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFEO_ECOLI pepcoil swissprot:YFEO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFEO_ECOLI pepdigest swissprot:YFEO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFEO_ECOLI pepinfo swissprot:YFEO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFEO_ECOLI pepnet swissprot:YFEO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFEO_ECOLI pepstats swissprot:YFEO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFEO_ECOLI pepwheel swissprot:YFEO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFEO_ECOLI pepwindow swissprot:YFEO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFEO_ECOLI sigcleave swissprot:YFEO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFEO_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES IMDH_ECOLI Kinetic parameters KM=61 uM for Inosine 5'-phosphate {ECO 0000269|PubMed 9341229}; KM=2000 uM for NAD(+) {ECO 0000269|PubMed 9341229}; KM=2.8 mM for K(+) {ECO 0000269|PubMed 9341229}; # BioGrid 4263221 63 # CATALYTIC ACTIVITY Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH. {ECO:0000255|HAMAP-Rule MF_01964}. # CDD cd00381 IMPDH # COFACTOR IMDH_ECOLI Name=K(+); Xref=ChEBI CHEBI 29103; Evidence={ECO 0000255|HAMAP-Rule MF_01964}; # DOMAIN IMDH_ECOLI The CBS domain of IMPDH is a negative trans-regulator of adenylate nucleotide synthesis, and this role is independent of the catalytic function of IMPDH in the de novo GMP biosynthesis. Deletion of the CBS domain derepresses the synthesis of AMP from IMP. {ECO 0000269|PubMed 18312263, ECO 0000269|PubMed 19153081}. # ENZYME REGULATION IMDH_ECOLI Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. IMP dehydrogenase subunit of E.coli contains a cysteine at the IMP binding site and is inhibited in a simple competitive manner by GMP. It does not exhibit allosteric properties as does IMP dehydrogenase from B.subtilis or S.typhimurium. {ECO 0000255|HAMAP-Rule MF_01964, ECO 0000269|PubMed 9341229}. # EcoGene EG10421 guaB # FUNCTION IMDH_ECOLI Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. {ECO 0000255|HAMAP-Rule MF_01964, ECO 0000269|PubMed 9341229}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0000166 nucleotide binding; IEA:UniProtKB-HAMAP. # GO_function GO:0003938 IMP dehydrogenase activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006177 GMP biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0006183 GTP biosynthetic process; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.70 -; 1. # HAMAP MF_01964 IMPDH # InterPro IPR000644 CBS_dom # InterPro IPR001093 IMP_DH_GMPRt # InterPro IPR005990 IMP_DH # InterPro IPR013785 Aldolase_TIM # InterPro IPR015875 IMP_DH/GMP_Rdtase_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00983 Drug metabolism - other enzymes # Organism IMDH_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11911:SF6 PTHR11911:SF6; 2 # PATHWAY Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1. {ECO 0000255|HAMAP-Rule:MF_01964}. # PATRIC 32120407 VBIEscCol129921_2606 # PIR C65027 DEECIP # PIRSF PIRSF000130 IMPDH # PROSITE PS00487 IMP_DH_GMP_RED # PROSITE PS51371 CBS; 2 # Pfam PF00478 IMPDH # Pfam PF00571 CBS; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Inosine-5'-monophosphate dehydrogenase {ECO:0000255|HAMAP-Rule MF_01964} # RefSeq NP_417003 NC_000913.3 # RefSeq WP_001299507 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA26133.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the IMPDH/GMPR family. {ECO:0000255|HAMAP- Rule MF_01964}. # SIMILARITY Contains 2 CBS domains. {ECO:0000255|HAMAP- Rule MF_01964}. # SMART SM00116 CBS; 2 # SUBUNIT IMDH_ECOLI Homotetramer. {ECO 0000255|HAMAP-Rule MF_01964, ECO 0000269|PubMed 9341229}. # TIGRFAMs TIGR01302 IMP_dehydrog # UniPathway UPA00601 UER00295 # eggNOG COG0516 LUCA # eggNOG COG0517 LUCA # eggNOG ENOG4105CP4 Bacteria BLAST swissprot:IMDH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:IMDH_ECOLI BioCyc ECOL316407:JW5401-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5401-MONOMER BioCyc EcoCyc:IMP-DEHYDROG-MONOMER http://biocyc.org/getid?id=EcoCyc:IMP-DEHYDROG-MONOMER BioCyc MetaCyc:IMP-DEHYDROG-MONOMER http://biocyc.org/getid?id=MetaCyc:IMP-DEHYDROG-MONOMER COG COG0516 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0516 COG COG0517 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0517 DIP DIP-36207N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36207N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1002/elps.1150190539 http://dx.doi.org/10.1002/elps.1150190539 DOI 10.1006/jmbi.1998.1726 http://dx.doi.org/10.1006/jmbi.1998.1726 DOI 10.1016/0378-1119(85)90068-X http://dx.doi.org/10.1016/0378-1119(85)90068-X DOI 10.1021/bi9714161 http://dx.doi.org/10.1021/bi9714161 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M808541200 http://dx.doi.org/10.1074/jbc.M808541200 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/nar/13.4.1303 http://dx.doi.org/10.1093/nar/13.4.1303 DOI 10.1111/j.1365-2958.2008.06153.x http://dx.doi.org/10.1111/j.1365-2958.2008.06153.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.205 {ECO:0000255|HAMAP-Rule:MF_01964} http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.205 {ECO:0000255|HAMAP-Rule:MF_01964} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M10101 http://www.ebi.ac.uk/ena/data/view/M10101 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X02209 http://www.ebi.ac.uk/ena/data/view/X02209 ENZYME 1.1.1.205 {ECO:0000255|HAMAP-Rule:MF_01964} http://enzyme.expasy.org/EC/1.1.1.205 {ECO:0000255|HAMAP-Rule:MF_01964} EchoBASE EB0416 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0416 EcoGene EG10421 http://www.ecogene.org/geneInfo.php?eg_id=EG10421 EnsemblBacteria AAC75561 http://www.ensemblgenomes.org/id/AAC75561 EnsemblBacteria AAC75561 http://www.ensemblgenomes.org/id/AAC75561 EnsemblBacteria BAA16395 http://www.ensemblgenomes.org/id/BAA16395 EnsemblBacteria BAA16395 http://www.ensemblgenomes.org/id/BAA16395 EnsemblBacteria BAA16395 http://www.ensemblgenomes.org/id/BAA16395 EnsemblBacteria b2508 http://www.ensemblgenomes.org/id/b2508 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000166 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000166 GO_function GO:0003938 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003938 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006177 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006177 GO_process GO:0006183 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006183 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 946985 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946985 HAMAP MF_01964 http://hamap.expasy.org/unirule/MF_01964 HOGENOM HOG000165755 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000165755&db=HOGENOM6 InParanoid P0ADG7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADG7 IntAct P0ADG7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADG7* IntEnz 1.1.1.205 {ECO:0000255|HAMAP-Rule:MF_01964} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.205 {ECO:0000255|HAMAP-Rule:MF_01964} InterPro IPR000644 http://www.ebi.ac.uk/interpro/entry/IPR000644 InterPro IPR001093 http://www.ebi.ac.uk/interpro/entry/IPR001093 InterPro IPR005990 http://www.ebi.ac.uk/interpro/entry/IPR005990 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR015875 http://www.ebi.ac.uk/interpro/entry/IPR015875 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5401 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5401 KEGG_Gene eco:b2508 http://www.genome.jp/dbget-bin/www_bget?eco:b2508 KEGG_Orthology KO:K00088 http://www.genome.jp/dbget-bin/www_bget?KO:K00088 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00983 http://www.genome.jp/kegg-bin/show_pathway?ko00983 KEGG_Reaction rn:R01130 http://www.genome.jp/dbget-bin/www_bget?rn:R01130 KEGG_Reaction rn:R08240 http://www.genome.jp/dbget-bin/www_bget?rn:R08240 MINT MINT-1235980 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1235980 OMA SSMGYCG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SSMGYCG PANTHER PTHR11911:SF6 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11911:SF6 PROSITE PS00487 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00487 PROSITE PS51371 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51371 PSORT swissprot:IMDH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:IMDH_ECOLI PSORT-B swissprot:IMDH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:IMDH_ECOLI PSORT2 swissprot:IMDH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:IMDH_ECOLI Pfam PF00478 http://pfam.xfam.org/family/PF00478 Pfam PF00571 http://pfam.xfam.org/family/PF00571 Phobius swissprot:IMDH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:IMDH_ECOLI PhylomeDB P0ADG7 http://phylomedb.org/?seqid=P0ADG7 ProteinModelPortal P0ADG7 http://www.proteinmodelportal.org/query/uniprot/P0ADG7 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1736096 http://www.ncbi.nlm.nih.gov/pubmed/1736096 PubMed 18312263 http://www.ncbi.nlm.nih.gov/pubmed/18312263 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 19153081 http://www.ncbi.nlm.nih.gov/pubmed/19153081 PubMed 2860637 http://www.ncbi.nlm.nih.gov/pubmed/2860637 PubMed 2998937 http://www.ncbi.nlm.nih.gov/pubmed/2998937 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9341229 http://www.ncbi.nlm.nih.gov/pubmed/9341229 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 PubMed 9629924 http://www.ncbi.nlm.nih.gov/pubmed/9629924 RefSeq NP_417003 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417003 RefSeq WP_001299507 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001299507 SMART SM00116 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00116 SMR P0ADG7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADG7 STRING 511145.b2508 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2508&targetmode=cogs STRING COG0516 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0516&targetmode=cogs STRING COG0517 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0517&targetmode=cogs SWISS-2DPAGE P0ADG7 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0ADG7 TIGRFAMs TIGR01302 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01302 UniProtKB IMDH_ECOLI http://www.uniprot.org/uniprot/IMDH_ECOLI UniProtKB-AC P0ADG7 http://www.uniprot.org/uniprot/P0ADG7 charge swissprot:IMDH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:IMDH_ECOLI eggNOG COG0516 http://eggnogapi.embl.de/nog_data/html/tree/COG0516 eggNOG COG0517 http://eggnogapi.embl.de/nog_data/html/tree/COG0517 eggNOG ENOG4105CP4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CP4 epestfind swissprot:IMDH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:IMDH_ECOLI garnier swissprot:IMDH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:IMDH_ECOLI helixturnhelix swissprot:IMDH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:IMDH_ECOLI hmoment swissprot:IMDH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:IMDH_ECOLI iep swissprot:IMDH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:IMDH_ECOLI inforesidue swissprot:IMDH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:IMDH_ECOLI octanol swissprot:IMDH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:IMDH_ECOLI pepcoil swissprot:IMDH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:IMDH_ECOLI pepdigest swissprot:IMDH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:IMDH_ECOLI pepinfo swissprot:IMDH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:IMDH_ECOLI pepnet swissprot:IMDH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:IMDH_ECOLI pepstats swissprot:IMDH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:IMDH_ECOLI pepwheel swissprot:IMDH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:IMDH_ECOLI pepwindow swissprot:IMDH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:IMDH_ECOLI sigcleave swissprot:IMDH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:IMDH_ECOLI ## Database ID URL or Descriptions # AltName IDNK_ECOLI Gluconate kinase 1 # BioGrid 4261380 10 # CATALYTIC ACTIVITY IDNK_ECOLI ATP + D-gluconate = ADP + 6-phospho-D- gluconate. # CDD cd02021 GntK # EcoGene EG12152 idnK # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0046316 gluconokinase activity; IDA:EcoCyc. # GO_process GO:0019521 D-gluconate metabolic process; IMP:EcoCyc. # GO_process GO:0046183 L-idonate catabolic process; IMP:EcoCyc. # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.300 -; 1. # IntAct P39208 8 # InterPro IPR006001 Therm_gnt_kin # InterPro IPR027417 P-loop_NTPase # InterPro IPR031322 Shikimate/glucono_kinase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00030 Pentose phosphate pathway # Organism IDNK_ECOLI Escherichia coli (strain K12) # PATHWAY IDNK_ECOLI Carbohydrate acid metabolism; L-idonate degradation. # PATRIC 32124109 VBIEscCol129921_4399 # PIR S56494 S56494 # Pfam PF01202 SKI # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName IDNK_ECOLI Thermosensitive gluconokinase # RefSeq NP_418689 NC_000913.3 # RefSeq WP_000896738 NZ_LN832404.1 # SIMILARITY Belongs to the gluconokinase GntK/GntV family. {ECO 0000305}. # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR01313 therm_gnt_kin # eggNOG COG3265 LUCA # eggNOG ENOG4108Z67 Bacteria BLAST swissprot:IDNK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:IDNK_ECOLI BioCyc ECOL316407:JW4225-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4225-MONOMER BioCyc EcoCyc:GLUCONOKINI-MONOMER http://biocyc.org/getid?id=EcoCyc:GLUCONOKINI-MONOMER BioCyc MetaCyc:GLUCONOKINI-MONOMER http://biocyc.org/getid?id=MetaCyc:GLUCONOKINI-MONOMER COG COG3265 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3265 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.12 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.12 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M96355 http://www.ebi.ac.uk/ena/data/view/M96355 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 2.7.1.12 http://enzyme.expasy.org/EC/2.7.1.12 EchoBASE EB2072 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2072 EcoGene EG12152 http://www.ecogene.org/geneInfo.php?eg_id=EG12152 EnsemblBacteria AAC77225 http://www.ensemblgenomes.org/id/AAC77225 EnsemblBacteria AAC77225 http://www.ensemblgenomes.org/id/AAC77225 EnsemblBacteria BAE78265 http://www.ensemblgenomes.org/id/BAE78265 EnsemblBacteria BAE78265 http://www.ensemblgenomes.org/id/BAE78265 EnsemblBacteria BAE78265 http://www.ensemblgenomes.org/id/BAE78265 EnsemblBacteria b4268 http://www.ensemblgenomes.org/id/b4268 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0046316 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046316 GO_process GO:0019521 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019521 GO_process GO:0046183 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046183 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 946066 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946066 HOGENOM HOG000032567 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000032567&db=HOGENOM6 InParanoid P39208 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39208 IntAct P39208 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39208* IntEnz 2.7.1.12 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.12 InterPro IPR006001 http://www.ebi.ac.uk/interpro/entry/IPR006001 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR031322 http://www.ebi.ac.uk/interpro/entry/IPR031322 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4225 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4225 KEGG_Gene eco:b4268 http://www.genome.jp/dbget-bin/www_bget?eco:b4268 KEGG_Orthology KO:K00851 http://www.genome.jp/dbget-bin/www_bget?KO:K00851 KEGG_Pathway ko00030 http://www.genome.jp/kegg-bin/show_pathway?ko00030 KEGG_Reaction rn:R01737 http://www.genome.jp/dbget-bin/www_bget?rn:R01737 OMA HHAPESI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HHAPESI PSORT swissprot:IDNK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:IDNK_ECOLI PSORT-B swissprot:IDNK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:IDNK_ECOLI PSORT2 swissprot:IDNK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:IDNK_ECOLI Pfam PF01202 http://pfam.xfam.org/family/PF01202 Phobius swissprot:IDNK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:IDNK_ECOLI PhylomeDB P39208 http://phylomedb.org/?seqid=P39208 ProteinModelPortal P39208 http://www.proteinmodelportal.org/query/uniprot/P39208 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9658018 http://www.ncbi.nlm.nih.gov/pubmed/9658018 RefSeq NP_418689 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418689 RefSeq WP_000896738 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000896738 SMR P39208 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39208 STRING 511145.b4268 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4268&targetmode=cogs STRING COG3265 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3265&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR01313 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01313 UniProtKB IDNK_ECOLI http://www.uniprot.org/uniprot/IDNK_ECOLI UniProtKB-AC P39208 http://www.uniprot.org/uniprot/P39208 charge swissprot:IDNK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:IDNK_ECOLI eggNOG COG3265 http://eggnogapi.embl.de/nog_data/html/tree/COG3265 eggNOG ENOG4108Z67 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Z67 epestfind swissprot:IDNK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:IDNK_ECOLI garnier swissprot:IDNK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:IDNK_ECOLI helixturnhelix swissprot:IDNK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:IDNK_ECOLI hmoment swissprot:IDNK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:IDNK_ECOLI iep swissprot:IDNK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:IDNK_ECOLI inforesidue swissprot:IDNK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:IDNK_ECOLI octanol swissprot:IDNK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:IDNK_ECOLI pepcoil swissprot:IDNK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:IDNK_ECOLI pepdigest swissprot:IDNK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:IDNK_ECOLI pepinfo swissprot:IDNK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:IDNK_ECOLI pepnet swissprot:IDNK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:IDNK_ECOLI pepstats swissprot:IDNK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:IDNK_ECOLI pepwheel swissprot:IDNK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:IDNK_ECOLI pepwindow swissprot:IDNK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:IDNK_ECOLI sigcleave swissprot:IDNK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:IDNK_ECOLI ## Database ID URL or Descriptions # AltName STFP_ECOLI Uncharacterized protein StfP from lambdoid prophage e14 region # BioGrid 4262856 14 # EcoGene EG12877 stfP # Organism STFP_ECOLI Escherichia coli (strain K12) # PATRIC 32117545 VBIEscCol129921_1195 # PIR G64860 G64860 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Uncharacterized protein StfP {ECO 0000305} # RefSeq NP_415672 NC_000913.3 # SIMILARITY To E.coli YfdL and M.jannaschii MJ0347. {ECO 0000305}. # eggNOG ENOG4105Y9F Bacteria # eggNOG ENOG4112657 LUCA BLAST swissprot:STFP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:STFP_ECOLI BioCyc ECOL316407:JW1140-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1140-MONOMER BioCyc EcoCyc:EG12877-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12877-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X01805 http://www.ebi.ac.uk/ena/data/view/X01805 EchoBASE EB2715 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2715 EcoGene EG12877 http://www.ecogene.org/geneInfo.php?eg_id=EG12877 EnsemblBacteria AAC74238 http://www.ensemblgenomes.org/id/AAC74238 EnsemblBacteria AAC74238 http://www.ensemblgenomes.org/id/AAC74238 EnsemblBacteria BAA35980 http://www.ensemblgenomes.org/id/BAA35980 EnsemblBacteria BAA35980 http://www.ensemblgenomes.org/id/BAA35980 EnsemblBacteria BAA35980 http://www.ensemblgenomes.org/id/BAA35980 EnsemblBacteria b1154 http://www.ensemblgenomes.org/id/b1154 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945726 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945726 HOGENOM HOG000267967 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267967&db=HOGENOM6 InParanoid P45581 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45581 KEGG_Gene ecj:JW1140 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1140 KEGG_Gene eco:b1154 http://www.genome.jp/dbget-bin/www_bget?eco:b1154 PSORT swissprot:STFP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:STFP_ECOLI PSORT-B swissprot:STFP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:STFP_ECOLI PSORT2 swissprot:STFP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:STFP_ECOLI Phobius swissprot:STFP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:STFP_ECOLI ProteinModelPortal P45581 http://www.proteinmodelportal.org/query/uniprot/P45581 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3894006 http://www.ncbi.nlm.nih.gov/pubmed/3894006 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415672 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415672 SMR P45581 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45581 STRING 511145.b1154 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1154&targetmode=cogs UniProtKB STFP_ECOLI http://www.uniprot.org/uniprot/STFP_ECOLI UniProtKB-AC P45581 http://www.uniprot.org/uniprot/P45581 charge swissprot:STFP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:STFP_ECOLI eggNOG ENOG4105Y9F http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105Y9F eggNOG ENOG4112657 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4112657 epestfind swissprot:STFP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:STFP_ECOLI garnier swissprot:STFP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:STFP_ECOLI helixturnhelix swissprot:STFP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:STFP_ECOLI hmoment swissprot:STFP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:STFP_ECOLI iep swissprot:STFP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:STFP_ECOLI inforesidue swissprot:STFP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:STFP_ECOLI octanol swissprot:STFP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:STFP_ECOLI pepcoil swissprot:STFP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:STFP_ECOLI pepdigest swissprot:STFP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:STFP_ECOLI pepinfo swissprot:STFP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:STFP_ECOLI pepnet swissprot:STFP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:STFP_ECOLI pepstats swissprot:STFP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:STFP_ECOLI pepwheel swissprot:STFP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:STFP_ECOLI pepwindow swissprot:STFP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:STFP_ECOLI sigcleave swissprot:STFP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:STFP_ECOLI ## Database ID URL or Descriptions # BioGrid 4259587 14 # EcoGene EG11241 ycaC # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0016787 hydrolase activity; IEA:UniProtKB-KW. # GO_process GO:0008152 metabolic process; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.850 -; 1. # IntAct P21367 3 # InterPro IPR000868 Isochorismatase-like # Organism YCAC_ECOLI Escherichia coli (strain K12) # PATRIC 32117005 VBIEscCol129921_0927 # PDB 1YAC X-ray; 1.80 A; A/B=1-208 # PIR S09671 S09671 # Pfam PF00857 Isochorismatase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCAC_ECOLI Uncharacterized protein YcaC # RefSeq NP_415417 NC_000913.3 # RefSeq WP_000165879 NZ_LN832404.1 # SUBUNIT YCAC_ECOLI Homooctamer composed of two tetrameric rings. # SUPFAM SSF52499 SSF52499 # eggNOG COG1335 LUCA # eggNOG ENOG4105CHJ Bacteria BLAST swissprot:YCAC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCAC_ECOLI BioCyc ECOL316407:JW0880-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0880-MONOMER BioCyc EcoCyc:EG11241-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11241-MONOMER DIP DIP-11462N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11462N DOI 10.1016/S0969-2126(98)00132-4 http://dx.doi.org/10.1016/S0969-2126(98)00132-4 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1988.tb00090.x http://dx.doi.org/10.1111/j.1365-2958.1988.tb00090.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J03412 http://www.ebi.ac.uk/ena/data/view/J03412 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1223 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1223 EcoGene EG11241 http://www.ecogene.org/geneInfo.php?eg_id=EG11241 EnsemblBacteria AAC73983 http://www.ensemblgenomes.org/id/AAC73983 EnsemblBacteria AAC73983 http://www.ensemblgenomes.org/id/AAC73983 EnsemblBacteria BAA35629 http://www.ensemblgenomes.org/id/BAA35629 EnsemblBacteria BAA35629 http://www.ensemblgenomes.org/id/BAA35629 EnsemblBacteria BAA35629 http://www.ensemblgenomes.org/id/BAA35629 EnsemblBacteria b0897 http://www.ensemblgenomes.org/id/b0897 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0016787 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016787 GO_process GO:0008152 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008152 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.850 http://www.cathdb.info/version/latest/superfamily/3.40.50.850 GeneID 945512 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945512 HOGENOM HOG000167093 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000167093&db=HOGENOM6 InParanoid P21367 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P21367 IntAct P21367 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P21367* InterPro IPR000868 http://www.ebi.ac.uk/interpro/entry/IPR000868 KEGG_Gene ecj:JW0880 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0880 KEGG_Gene eco:b0897 http://www.genome.jp/dbget-bin/www_bget?eco:b0897 OMA MYPDAPL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MYPDAPL PDB 1YAC http://www.ebi.ac.uk/pdbe-srv/view/entry/1YAC PDBsum 1YAC http://www.ebi.ac.uk/pdbsum/1YAC PSORT swissprot:YCAC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCAC_ECOLI PSORT-B swissprot:YCAC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCAC_ECOLI PSORT2 swissprot:YCAC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCAC_ECOLI Pfam PF00857 http://pfam.xfam.org/family/PF00857 Phobius swissprot:YCAC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCAC_ECOLI PhylomeDB P21367 http://phylomedb.org/?seqid=P21367 ProteinModelPortal P21367 http://www.proteinmodelportal.org/query/uniprot/P21367 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3062312 http://www.ncbi.nlm.nih.gov/pubmed/3062312 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9782055 http://www.ncbi.nlm.nih.gov/pubmed/9782055 RefSeq NP_415417 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415417 RefSeq WP_000165879 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000165879 SMR P21367 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P21367 STRING 511145.b0897 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0897&targetmode=cogs SUPFAM SSF52499 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52499 UniProtKB YCAC_ECOLI http://www.uniprot.org/uniprot/YCAC_ECOLI UniProtKB-AC P21367 http://www.uniprot.org/uniprot/P21367 charge swissprot:YCAC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCAC_ECOLI eggNOG COG1335 http://eggnogapi.embl.de/nog_data/html/tree/COG1335 eggNOG ENOG4105CHJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CHJ epestfind swissprot:YCAC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCAC_ECOLI garnier swissprot:YCAC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCAC_ECOLI helixturnhelix swissprot:YCAC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCAC_ECOLI hmoment swissprot:YCAC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCAC_ECOLI iep swissprot:YCAC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCAC_ECOLI inforesidue swissprot:YCAC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCAC_ECOLI octanol swissprot:YCAC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCAC_ECOLI pepcoil swissprot:YCAC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCAC_ECOLI pepdigest swissprot:YCAC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCAC_ECOLI pepinfo swissprot:YCAC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCAC_ECOLI pepnet swissprot:YCAC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCAC_ECOLI pepstats swissprot:YCAC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCAC_ECOLI pepwheel swissprot:YCAC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCAC_ECOLI pepwindow swissprot:YCAC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCAC_ECOLI sigcleave swissprot:YCAC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCAC_ECOLI ## Database ID URL or Descriptions # AltName CRL_ECOLI Curlin genes transcriptional activatory protein # BioGrid 4260821 12 # CAUTION A pseudogene in strain MG1655 / ATCC 700926, but not its parent MG1655 / ATCC 47076. In ATCC 700926 IS1I has recently inserted into the gene (PubMed:22081388). {ECO 0000305|PubMed:22081388}. # EcoGene EG11092 crl # FUNCTION CRL_ECOLI Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes, such as the csgBAC operon encoding the subunits of curli proteins. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 (rpoD) and sigma-32 (rpoH). {ECO 0000269|PubMed 1357528, ECO 0000269|PubMed 16980472}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0043623 cellular protein complex assembly; IDA:EcoCyc. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # HAMAP MF_01178 Crl # INDUCTION CRL_ECOLI Induced at stationary phase, and by low temperatures. # IntAct P24251 11 # InterPro IPR009986 Tscrpt_reg_Crl # Organism CRL_ECOLI Escherichia coli (strain K12) # PATRIC 32115595 VBIEscCol129921_0242 # PIR A64749 A64749 # Pfam PF07417 Crl # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CRL_ECOLI Sigma factor-binding protein Crl # RefSeq WP_000174689 NZ_LN832404.1 # SIMILARITY Belongs to the Crl family. {ECO 0000305}. # SUBCELLULAR LOCATION CRL_ECOLI Cytoplasm. # eggNOG ENOG4108UVK Bacteria # eggNOG ENOG4111IQF LUCA BLAST swissprot:CRL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CRL_ECOLI BioCyc ECOL316407:JW0230-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0230-MONOMER BioCyc EcoCyc:EG11092-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11092-MONOMER DOI 10.1016/0022-2836(83)90110-9 http://dx.doi.org/10.1016/0022-2836(83)90110-9 DOI 10.1016/0378-1119(84)90052-0 http://dx.doi.org/10.1016/0378-1119(84)90052-0 DOI 10.1038/338652a0 http://dx.doi.org/10.1038/338652a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1998.01007.x http://dx.doi.org/10.1046/j.1365-2958.1998.01007.x DOI 10.1074/jbc.M314145200 http://dx.doi.org/10.1074/jbc.M314145200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01266-06 http://dx.doi.org/10.1128/JB.01266-06 DOI 10.1128/JB.06087-11 http://dx.doi.org/10.1128/JB.06087-11 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M13422 http://www.ebi.ac.uk/ena/data/view/M13422 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EMBL V00316 http://www.ebi.ac.uk/ena/data/view/V00316 EMBL X67207 http://www.ebi.ac.uk/ena/data/view/X67207 EchoBASE EB1084 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1084 EcoGene EG11092 http://www.ecogene.org/geneInfo.php?eg_id=EG11092 EnsemblBacteria BAA77909 http://www.ensemblgenomes.org/id/BAA77909 EnsemblBacteria BAA77909 http://www.ensemblgenomes.org/id/BAA77909 EnsemblBacteria BAA77909 http://www.ensemblgenomes.org/id/BAA77909 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0043623 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043623 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 HAMAP MF_01178 http://hamap.expasy.org/unirule/MF_01178 HOGENOM HOG000282284 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000282284&db=HOGENOM6 IntAct P24251 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P24251* InterPro IPR009986 http://www.ebi.ac.uk/interpro/entry/IPR009986 KEGG_Gene ecj:JW0230 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0230 OMA GWWLNLE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GWWLNLE PSORT swissprot:CRL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CRL_ECOLI PSORT-B swissprot:CRL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CRL_ECOLI PSORT2 swissprot:CRL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CRL_ECOLI Pfam PF07417 http://pfam.xfam.org/family/PF07417 Phobius swissprot:CRL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CRL_ECOLI ProteinModelPortal P24251 http://www.proteinmodelportal.org/query/uniprot/P24251 PubMed 1357528 http://www.ncbi.nlm.nih.gov/pubmed/1357528 PubMed 14978043 http://www.ncbi.nlm.nih.gov/pubmed/14978043 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16980472 http://www.ncbi.nlm.nih.gov/pubmed/16980472 PubMed 1729226 http://www.ncbi.nlm.nih.gov/pubmed/1729226 PubMed 22081388 http://www.ncbi.nlm.nih.gov/pubmed/22081388 PubMed 2649795 http://www.ncbi.nlm.nih.gov/pubmed/2649795 PubMed 6341601 http://www.ncbi.nlm.nih.gov/pubmed/6341601 PubMed 6397401 http://www.ncbi.nlm.nih.gov/pubmed/6397401 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9767590 http://www.ncbi.nlm.nih.gov/pubmed/9767590 RefSeq WP_000174689 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000174689 SMR P24251 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P24251 STRING 511145.b0240 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0240&targetmode=cogs UniProtKB CRL_ECOLI http://www.uniprot.org/uniprot/CRL_ECOLI UniProtKB-AC P24251 http://www.uniprot.org/uniprot/P24251 charge swissprot:CRL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CRL_ECOLI eggNOG ENOG4108UVK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UVK eggNOG ENOG4111IQF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111IQF epestfind swissprot:CRL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CRL_ECOLI garnier swissprot:CRL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CRL_ECOLI helixturnhelix swissprot:CRL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CRL_ECOLI hmoment swissprot:CRL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CRL_ECOLI iep swissprot:CRL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CRL_ECOLI inforesidue swissprot:CRL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CRL_ECOLI octanol swissprot:CRL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CRL_ECOLI pepcoil swissprot:CRL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CRL_ECOLI pepdigest swissprot:CRL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CRL_ECOLI pepinfo swissprot:CRL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CRL_ECOLI pepnet swissprot:CRL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CRL_ECOLI pepstats swissprot:CRL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CRL_ECOLI pepwheel swissprot:CRL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CRL_ECOLI pepwindow swissprot:CRL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CRL_ECOLI sigcleave swissprot:CRL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CRL_ECOLI ## Database ID URL or Descriptions # AltName Thr operon attenuator {ECO:0000255|HAMAP-Rule MF_01907} # BioGrid 4261932 4 # EcoGene EG11277 thrL # FUNCTION LPT_ECOLI This protein is involved in control of the biosynthesis of threonine. # GO_process GO:0009088 threonine biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0031555 transcriptional attenuation; IMP:EcoCyc. # GO_process GO:0031556 transcriptional attenuation by ribosome; IEA:UniProtKB-HAMAP. # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # HAMAP MF_01907 Leader_Thr # InterPro IPR011720 Thr_lead_pept # Organism LPT_ECOLI Escherichia coli (strain K12) # PIR A03595 LFECT # Pfam PF08254 Leader_Thr # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Thr operon leader peptide {ECO:0000255|HAMAP-Rule MF_01907} # RefSeq NP_414542 NC_000913.3 # RefSeq WP_001386572 NZ_LN832404.1 # SIMILARITY Belongs to the Thr operon leader peptide family. {ECO:0000255|HAMAP-Rule MF_01907}. # TIGRFAMs TIGR02077 thr_lead_pep BLAST swissprot:LPT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LPT_ECOLI BioCyc ECOL316407:JW4367-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4367-MONOMER BioCyc EcoCyc:EG11277-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11277-MONOMER DOI 10.1016/0022-2836(85)90169-X http://dx.doi.org/10.1016/0022-2836(85)90169-X DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.76.4.1706 http://dx.doi.org/10.1073/pnas.76.4.1706 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01706 http://www.ebi.ac.uk/ena/data/view/J01706 EMBL M28570 http://www.ebi.ac.uk/ena/data/view/M28570 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL V00360 http://www.ebi.ac.uk/ena/data/view/V00360 EMBL X68872 http://www.ebi.ac.uk/ena/data/view/X68872 EchoBASE EB1255 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1255 EcoGene EG11277 http://www.ecogene.org/geneInfo.php?eg_id=EG11277 EnsemblBacteria AAC73112 http://www.ensemblgenomes.org/id/AAC73112 EnsemblBacteria AAC73112 http://www.ensemblgenomes.org/id/AAC73112 EnsemblBacteria BAE76026 http://www.ensemblgenomes.org/id/BAE76026 EnsemblBacteria BAE76026 http://www.ensemblgenomes.org/id/BAE76026 EnsemblBacteria BAE76026 http://www.ensemblgenomes.org/id/BAE76026 EnsemblBacteria b0001 http://www.ensemblgenomes.org/id/b0001 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0009088 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009088 GO_process GO:0031555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031555 GO_process GO:0031556 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031556 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 944742 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944742 HAMAP MF_01907 http://hamap.expasy.org/unirule/MF_01907 InterPro IPR011720 http://www.ebi.ac.uk/interpro/entry/IPR011720 KEGG_Gene ecj:JW4367 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4367 KEGG_Gene eco:b0001 http://www.genome.jp/dbget-bin/www_bget?eco:b0001 KEGG_Orthology KO:K08278 http://www.genome.jp/dbget-bin/www_bget?KO:K08278 PSORT swissprot:LPT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LPT_ECOLI PSORT-B swissprot:LPT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LPT_ECOLI PSORT2 swissprot:LPT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LPT_ECOLI Pfam PF08254 http://pfam.xfam.org/family/PF08254 Phobius swissprot:LPT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LPT_ECOLI PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2410621 http://www.ncbi.nlm.nih.gov/pubmed/2410621 PubMed 287010 http://www.ncbi.nlm.nih.gov/pubmed/287010 PubMed 6277952 http://www.ncbi.nlm.nih.gov/pubmed/6277952 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414542 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414542 RefSeq WP_001386572 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001386572 STRING 511145.b0001 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0001&targetmode=cogs TIGRFAMs TIGR02077 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02077 UniProtKB LPT_ECOLI http://www.uniprot.org/uniprot/LPT_ECOLI UniProtKB-AC P0AD86 http://www.uniprot.org/uniprot/P0AD86 charge swissprot:LPT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LPT_ECOLI epestfind swissprot:LPT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LPT_ECOLI garnier swissprot:LPT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LPT_ECOLI helixturnhelix swissprot:LPT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LPT_ECOLI hmoment swissprot:LPT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LPT_ECOLI iep swissprot:LPT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LPT_ECOLI inforesidue swissprot:LPT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LPT_ECOLI octanol swissprot:LPT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LPT_ECOLI pepcoil swissprot:LPT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LPT_ECOLI pepdigest swissprot:LPT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LPT_ECOLI pepinfo swissprot:LPT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LPT_ECOLI pepnet swissprot:LPT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LPT_ECOLI pepstats swissprot:LPT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LPT_ECOLI pepwheel swissprot:LPT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LPT_ECOLI pepwindow swissprot:LPT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LPT_ECOLI sigcleave swissprot:LPT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LPT_ECOLI ## Database ID URL or Descriptions # AltName SGCC_ECOLI Putative PTS system EIIC component # BioGrid 4262751 6 # DOMAIN SGCC_ECOLI The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site. # EcoGene EG12556 sgcC # FUNCTION SGCC_ECOLI The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. {ECO 0000250}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015577 galactitol transmembrane transporter activity; IEA:InterPro. # GO_function GO:0090584 protein-phosphocysteine-galactitol-phosphotransferase system transporter activity; IBA:GO_Central. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IBA:GO_Central. # GO_process GO:0015796 galactitol transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR004703 PTS_sugar-sp_permease # InterPro IPR013014 PTS_EIIC_2 # InterPro IPR013853 GatC # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00279 PTS system, galactitol-specific II component # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko00052 Galactose metabolism # KEGG_Pathway ko02060 Phosphotransferase system (PTS) # Organism SGCC_ECOLI Escherichia coli (strain K12) # PATRIC 32124194 VBIEscCol129921_4440 # PIR S56529 S56529 # PIRSF PIRSF006304 GatC # PROSITE PS51104 PTS_EIIC_TYPE_2 # Pfam PF03611 EIIC-GAT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SGCC_ECOLI Putative permease IIC component # RefSeq NP_418724 NC_000913.3 # RefSeq WP_000460843 NZ_LN832404.1 # SIMILARITY Contains 1 PTS EIIC type-2 domain. {ECO:0000255|PROSITE-ProRule PRU00427}. # SUBCELLULAR LOCATION SGCC_ECOLI Cell inner membrane {ECO 0000255|PROSITE- ProRule PRU00427, ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00427, ECO 0000269|PubMed 15919996}. # TCDB 4.A.5.1 the pts galactitol (gat) family # TIGRFAMs TIGR00827 EIIC-GAT # eggNOG COG3775 LUCA # eggNOG ENOG4105DT3 Bacteria BLAST swissprot:SGCC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SGCC_ECOLI BioCyc ECOL316407:JW4266-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4266-MONOMER BioCyc EcoCyc:SGCC-MONOMER http://biocyc.org/getid?id=EcoCyc:SGCC-MONOMER BioCyc MetaCyc:SGCC-MONOMER http://biocyc.org/getid?id=MetaCyc:SGCC-MONOMER COG COG3775 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3775 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2444 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2444 EcoGene EG12556 http://www.ecogene.org/geneInfo.php?eg_id=EG12556 EnsemblBacteria AAC77260 http://www.ensemblgenomes.org/id/AAC77260 EnsemblBacteria AAC77260 http://www.ensemblgenomes.org/id/AAC77260 EnsemblBacteria BAE78295 http://www.ensemblgenomes.org/id/BAE78295 EnsemblBacteria BAE78295 http://www.ensemblgenomes.org/id/BAE78295 EnsemblBacteria BAE78295 http://www.ensemblgenomes.org/id/BAE78295 EnsemblBacteria b4304 http://www.ensemblgenomes.org/id/b4304 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015577 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015577 GO_function GO:0090584 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090584 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GO_process GO:0015796 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015796 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 946849 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946849 HOGENOM HOG000053574 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000053574&db=HOGENOM6 InParanoid P39365 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39365 InterPro IPR004703 http://www.ebi.ac.uk/interpro/entry/IPR004703 InterPro IPR013014 http://www.ebi.ac.uk/interpro/entry/IPR013014 InterPro IPR013853 http://www.ebi.ac.uk/interpro/entry/IPR013853 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW4266 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4266 KEGG_Gene eco:b4304 http://www.genome.jp/dbget-bin/www_bget?eco:b4304 KEGG_Orthology KO:K02775 http://www.genome.jp/dbget-bin/www_bget?KO:K02775 KEGG_Pathway ko00052 http://www.genome.jp/kegg-bin/show_pathway?ko00052 KEGG_Pathway ko02060 http://www.genome.jp/kegg-bin/show_pathway?ko02060 KEGG_Reaction rn:R05570 http://www.genome.jp/dbget-bin/www_bget?rn:R05570 OMA INFIMLT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=INFIMLT PROSITE PS51104 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51104 PSORT swissprot:SGCC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SGCC_ECOLI PSORT-B swissprot:SGCC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SGCC_ECOLI PSORT2 swissprot:SGCC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SGCC_ECOLI Pfam PF03611 http://pfam.xfam.org/family/PF03611 Phobius swissprot:SGCC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SGCC_ECOLI PhylomeDB P39365 http://phylomedb.org/?seqid=P39365 ProteinModelPortal P39365 http://www.proteinmodelportal.org/query/uniprot/P39365 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418724 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418724 RefSeq WP_000460843 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000460843 STRING 511145.b4304 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4304&targetmode=cogs STRING COG3775 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3775&targetmode=cogs TCDB 4.A.5.1 http://www.tcdb.org/search/result.php?tc=4.A.5.1 TIGRFAMs TIGR00827 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00827 UniProtKB SGCC_ECOLI http://www.uniprot.org/uniprot/SGCC_ECOLI UniProtKB-AC P39365 http://www.uniprot.org/uniprot/P39365 charge swissprot:SGCC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SGCC_ECOLI eggNOG COG3775 http://eggnogapi.embl.de/nog_data/html/tree/COG3775 eggNOG ENOG4105DT3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DT3 epestfind swissprot:SGCC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SGCC_ECOLI garnier swissprot:SGCC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SGCC_ECOLI helixturnhelix swissprot:SGCC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SGCC_ECOLI hmoment swissprot:SGCC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SGCC_ECOLI iep swissprot:SGCC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SGCC_ECOLI inforesidue swissprot:SGCC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SGCC_ECOLI octanol swissprot:SGCC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SGCC_ECOLI pepcoil swissprot:SGCC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SGCC_ECOLI pepdigest swissprot:SGCC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SGCC_ECOLI pepinfo swissprot:SGCC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SGCC_ECOLI pepnet swissprot:SGCC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SGCC_ECOLI pepstats swissprot:SGCC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SGCC_ECOLI pepwheel swissprot:SGCC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SGCC_ECOLI pepwindow swissprot:SGCC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SGCC_ECOLI sigcleave swissprot:SGCC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SGCC_ECOLI ## Database ID URL or Descriptions # BioGrid 4261488 9 # CDD cd00383 trans_reg_C # EcoGene EG12615 torR # FUNCTION TORR_ECOLI Member of the two-component regulatory system TorS/TorR involved in the anaerobic utilization of trimethylamine-N-oxide (TMAO). Phosphorylated TorR activates the transcription of the torCAD operon by binding to four decameric boxes located in the torCAD promoter. Box1, 2 and 4 contain the DNA sequence 5'- CTGTTCATAT-3' and box3 contains the DNA sequence 5'-CCGTTCATCC-3'. Phosphorylated as well as unphosphorylated TorR negatively regulates its own expression by binding to box1 and 2. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0000156 phosphorelay response regulator activity; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004871 signal transducer activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # IntAct P38684 4 # InterPro IPR001789 Sig_transdc_resp-reg_receiver # InterPro IPR001867 OmpR/PhoB-type_DNA-bd # InterPro IPR011006 CheY-like_superfamily # InterPro IPR011991 WHTH_DNA-bd_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02022 M00455 TorS-TorR (trimethylamine N-oxide respiration) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # Organism TORR_ECOLI Escherichia coli (strain K12) # PATRIC 32117215 VBIEscCol129921_1031 # PDB 1ZGZ X-ray; 1.80 A; A/B/C/D=1-122 # PIR A64841 A64841 # PROSITE PS50110 RESPONSE_REGULATORY # PROSITE PS51755 OMPR_PHOB # PTM TORR_ECOLI Phosphorylated and dephosphorylated by TorS. # Pfam PF00072 Response_reg # Pfam PF00486 Trans_reg_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TORR_ECOLI TorCAD operon transcriptional regulatory protein TorR # RefSeq NP_415515 NC_000913.3 # RefSeq WP_001120125 NZ_LN832404.1 # SIMILARITY Contains 1 OmpR/PhoB-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU01091}. # SIMILARITY Contains 1 response regulatory domain. {ECO:0000255|PROSITE-ProRule PRU00169}. # SMART SM00448 REC # SMART SM00862 Trans_reg_C # SUBCELLULAR LOCATION TORR_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Interacts with TorI. TorI binds to the effector domain of TorR. This interaction, which does not interfere with TorR DNA binding activity, probably prevents the recruitment of RNA polymerase to the torCAD promoter. {ECO:0000269|PubMed 15197250}. # SUPFAM SSF52172 SSF52172 # eggNOG COG0745 LUCA # eggNOG ENOG4106WF9 Bacteria BLAST swissprot:TORR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TORR_ECOLI BioCyc ECOL316407:JW0980-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0980-MONOMER BioCyc EcoCyc:TORR-MONOMER http://biocyc.org/getid?id=EcoCyc:TORR-MONOMER COG COG0745 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0745 DIP DIP-11016N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11016N DOI 10.1006/jmbi.1997.0919 http://dx.doi.org/10.1006/jmbi.1997.0919 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0401927101 http://dx.doi.org/10.1073/pnas.0401927101 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1995.mmi_17050971.x http://dx.doi.org/10.1111/j.1365-2958.1995.mmi_17050971.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.4.961-966.2000 http://dx.doi.org/10.1128/JB.182.4.961-966.2000 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X94231 http://www.ebi.ac.uk/ena/data/view/X94231 EchoBASE EB2499 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2499 EcoGene EG12615 http://www.ecogene.org/geneInfo.php?eg_id=EG12615 EnsemblBacteria AAC74080 http://www.ensemblgenomes.org/id/AAC74080 EnsemblBacteria AAC74080 http://www.ensemblgenomes.org/id/AAC74080 EnsemblBacteria BAA36137 http://www.ensemblgenomes.org/id/BAA36137 EnsemblBacteria BAA36137 http://www.ensemblgenomes.org/id/BAA36137 EnsemblBacteria BAA36137 http://www.ensemblgenomes.org/id/BAA36137 EnsemblBacteria b0995 http://www.ensemblgenomes.org/id/b0995 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000156 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000156 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 946182 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946182 HOGENOM HOG000034819 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000034819&db=HOGENOM6 InParanoid P38684 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P38684 IntAct P38684 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P38684* InterPro IPR001789 http://www.ebi.ac.uk/interpro/entry/IPR001789 InterPro IPR001867 http://www.ebi.ac.uk/interpro/entry/IPR001867 InterPro IPR011006 http://www.ebi.ac.uk/interpro/entry/IPR011006 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW0980 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0980 KEGG_Gene eco:b0995 http://www.genome.jp/dbget-bin/www_bget?eco:b0995 KEGG_Orthology KO:K07772 http://www.genome.jp/dbget-bin/www_bget?KO:K07772 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 MINT MINT-1283676 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1283676 OMA REVWGWD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=REVWGWD PDB 1ZGZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZGZ PDBsum 1ZGZ http://www.ebi.ac.uk/pdbsum/1ZGZ PROSITE PS50110 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50110 PROSITE PS51755 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51755 PSORT swissprot:TORR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TORR_ECOLI PSORT-B swissprot:TORR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TORR_ECOLI PSORT2 swissprot:TORR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TORR_ECOLI Pfam PF00072 http://pfam.xfam.org/family/PF00072 Pfam PF00486 http://pfam.xfam.org/family/PF00486 Phobius swissprot:TORR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TORR_ECOLI PhylomeDB P38684 http://phylomedb.org/?seqid=P38684 ProteinModelPortal P38684 http://www.proteinmodelportal.org/query/uniprot/P38684 PubMed 10648521 http://www.ncbi.nlm.nih.gov/pubmed/10648521 PubMed 15197250 http://www.ncbi.nlm.nih.gov/pubmed/15197250 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7798146 http://www.ncbi.nlm.nih.gov/pubmed/7798146 PubMed 8083154 http://www.ncbi.nlm.nih.gov/pubmed/8083154 PubMed 8596446 http://www.ncbi.nlm.nih.gov/pubmed/8596446 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9135110 http://www.ncbi.nlm.nih.gov/pubmed/9135110 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415515 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415515 RefSeq WP_001120125 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001120125 SMART SM00448 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00448 SMART SM00862 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00862 SMR P38684 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P38684 STRING 511145.b0995 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0995&targetmode=cogs STRING COG0745 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0745&targetmode=cogs SUPFAM SSF52172 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52172 UniProtKB TORR_ECOLI http://www.uniprot.org/uniprot/TORR_ECOLI UniProtKB-AC P38684 http://www.uniprot.org/uniprot/P38684 charge swissprot:TORR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TORR_ECOLI eggNOG COG0745 http://eggnogapi.embl.de/nog_data/html/tree/COG0745 eggNOG ENOG4106WF9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106WF9 epestfind swissprot:TORR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TORR_ECOLI garnier swissprot:TORR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TORR_ECOLI helixturnhelix swissprot:TORR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TORR_ECOLI hmoment swissprot:TORR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TORR_ECOLI iep swissprot:TORR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TORR_ECOLI inforesidue swissprot:TORR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TORR_ECOLI octanol swissprot:TORR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TORR_ECOLI pepcoil swissprot:TORR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TORR_ECOLI pepdigest swissprot:TORR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TORR_ECOLI pepinfo swissprot:TORR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TORR_ECOLI pepnet swissprot:TORR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TORR_ECOLI pepstats swissprot:TORR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TORR_ECOLI pepwheel swissprot:TORR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TORR_ECOLI pepwindow swissprot:TORR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TORR_ECOLI sigcleave swissprot:TORR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TORR_ECOLI ## Database ID URL or Descriptions # AltName DBHA_ECOLI HU-2 # AltName DBHA_ECOLI NS2 # BioGrid 4263459 132 # EcoGene EG10466 hupA # FUNCTION DBHA_ECOLI Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_component GO:1990178 HU-DNA complex; IDA:CACAO. # GO_function GO:0003677 DNA binding; IDA:EcoliWiki. # GO_process GO:0006351 transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0030261 chromosome condensation; IEA:UniProtKB-KW. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0051276 chromosome organization # Gene3D 4.10.520.10 -; 1. # INTERACTION DBHA_ECOLI Self; NbExp=2; IntAct=EBI-547648, EBI-547648; P03004 dnaA; NbExp=5; IntAct=EBI-547648, EBI-548951; P0ACF4 hupB; NbExp=6; IntAct=EBI-547648, EBI-370411; # IntAct P0ACF0 66 # InterPro IPR000119 Hist_DNA-bd # InterPro IPR010992 IHF-like_DNA-bd_dom # InterPro IPR020816 Histone-like_DNA-bd_CS # KEGG_Brite ko03032 DNA replication proteins # KEGG_Brite ko03036 Chromosome # KEGG_Brite ko03400 DNA repair and recombination proteins # Organism DBHA_ECOLI Escherichia coli (strain K12) # PATRIC 32123523 VBIEscCol129921_4114 # PDB 1MUL X-ray; 2.30 A; A=1-90 # PDB 2O97 X-ray; 2.45 A; A=1-90 # PDB 4YEW X-ray; 2.68 A; C=1-90 # PDB 4YEX X-ray; 3.20 A; A/C=1-90 # PDB 4YEY X-ray; 3.35 A; A/C=1-90 # PDB 4YF0 X-ray; 2.79 A; A/B=1-90 # PDB 4YFH X-ray; 3.49 A; A/B=1-90 # PDB 4YFT X-ray; 2.91 A; C=1-90 # PIR S06269 DNECS2 # PRINTS PR01727 DNABINDINGHU # PROSITE PS00045 HISTONE_LIKE # Pfam PF00216 Bac_DNA_binding # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DBHA_ECOLI DNA-binding protein HU-alpha # RefSeq NP_418428 NC_000913.3 # RefSeq WP_001044513 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial histone-like protein family. {ECO 0000305}. # SMART SM00411 BHL # SUBCELLULAR LOCATION DBHA_ECOLI Cytoplasm, nucleoid {ECO 0000269|PubMed 21903814}. Note=Scattered throughout the nucleoid (PubMed 21903814). {ECO 0000269|PubMed 21903814}. # SUBUNIT Heterodimer of an alpha and a beta chain. {ECO:0000269|PubMed 227733}. # SUPFAM SSF47729 SSF47729 # eggNOG COG0776 LUCA # eggNOG ENOG4105K70 Bacteria BLAST swissprot:DBHA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DBHA_ECOLI BioCyc ECOL316407:JW3964-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3964-MONOMER BioCyc EcoCyc:EG10466-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10466-MONOMER COG COG0776 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0776 DIP DIP-35892N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35892N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1007/BF00329674 http://dx.doi.org/10.1007/BF00329674 DOI 10.1016/0014-5793(78)80446-3 http://dx.doi.org/10.1016/0014-5793(78)80446-3 DOI 10.1016/0014-5793(78)80535-3 http://dx.doi.org/10.1016/0014-5793(78)80535-3 DOI 10.1016/0014-5793(79)80518-9 http://dx.doi.org/10.1016/0014-5793(79)80518-9 DOI 10.1016/S0022-2836(05)80119-6 http://dx.doi.org/10.1016/S0022-2836(05)80119-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1111/j.1432-1033.1980.tb05968.x http://dx.doi.org/10.1111/j.1432-1033.1980.tb05968.x DOI 10.1111/j.1574-6968.1998.tb13343.x http://dx.doi.org/10.1111/j.1574-6968.1998.tb13343.x DOI 10.1126/science.1204697 http://dx.doi.org/10.1126/science.1204697 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D12624 http://www.ebi.ac.uk/ena/data/view/D12624 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X05994 http://www.ebi.ac.uk/ena/data/view/X05994 EMBL X54555 http://www.ebi.ac.uk/ena/data/view/X54555 EchoBASE EB0461 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0461 EcoGene EG10466 http://www.ecogene.org/geneInfo.php?eg_id=EG10466 EnsemblBacteria AAC76974 http://www.ensemblgenomes.org/id/AAC76974 EnsemblBacteria AAC76974 http://www.ensemblgenomes.org/id/AAC76974 EnsemblBacteria BAE77319 http://www.ensemblgenomes.org/id/BAE77319 EnsemblBacteria BAE77319 http://www.ensemblgenomes.org/id/BAE77319 EnsemblBacteria BAE77319 http://www.ensemblgenomes.org/id/BAE77319 EnsemblBacteria b4000 http://www.ensemblgenomes.org/id/b4000 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:1990178 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990178 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0030261 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030261 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0051276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051276 Gene3D 4.10.520.10 http://www.cathdb.info/version/latest/superfamily/4.10.520.10 GeneID 948499 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948499 HOGENOM HOG000043828 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000043828&db=HOGENOM6 InParanoid P0ACF0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACF0 IntAct P0ACF0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACF0* InterPro IPR000119 http://www.ebi.ac.uk/interpro/entry/IPR000119 InterPro IPR010992 http://www.ebi.ac.uk/interpro/entry/IPR010992 InterPro IPR020816 http://www.ebi.ac.uk/interpro/entry/IPR020816 KEGG_Brite ko03032 http://www.genome.jp/dbget-bin/www_bget?ko03032 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW3964 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3964 KEGG_Gene eco:b4000 http://www.genome.jp/dbget-bin/www_bget?eco:b4000 KEGG_Orthology KO:K05787 http://www.genome.jp/dbget-bin/www_bget?KO:K05787 MINT MINT-1244407 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1244407 OMA MNSITYE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MNSITYE PDB 1MUL http://www.ebi.ac.uk/pdbe-srv/view/entry/1MUL PDB 2O97 http://www.ebi.ac.uk/pdbe-srv/view/entry/2O97 PDB 4YEW http://www.ebi.ac.uk/pdbe-srv/view/entry/4YEW PDB 4YEX http://www.ebi.ac.uk/pdbe-srv/view/entry/4YEX PDB 4YEY http://www.ebi.ac.uk/pdbe-srv/view/entry/4YEY PDB 4YF0 http://www.ebi.ac.uk/pdbe-srv/view/entry/4YF0 PDB 4YFH http://www.ebi.ac.uk/pdbe-srv/view/entry/4YFH PDB 4YFT http://www.ebi.ac.uk/pdbe-srv/view/entry/4YFT PDBsum 1MUL http://www.ebi.ac.uk/pdbsum/1MUL PDBsum 2O97 http://www.ebi.ac.uk/pdbsum/2O97 PDBsum 4YEW http://www.ebi.ac.uk/pdbsum/4YEW PDBsum 4YEX http://www.ebi.ac.uk/pdbsum/4YEX PDBsum 4YEY http://www.ebi.ac.uk/pdbsum/4YEY PDBsum 4YF0 http://www.ebi.ac.uk/pdbsum/4YF0 PDBsum 4YFH http://www.ebi.ac.uk/pdbsum/4YFH PDBsum 4YFT http://www.ebi.ac.uk/pdbsum/4YFT PRINTS PR01727 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01727 PROSITE PS00045 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00045 PSORT swissprot:DBHA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DBHA_ECOLI PSORT-B swissprot:DBHA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DBHA_ECOLI PSORT2 swissprot:DBHA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DBHA_ECOLI Pfam PF00216 http://pfam.xfam.org/family/PF00216 Phobius swissprot:DBHA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DBHA_ECOLI PhylomeDB P0ACF0 http://phylomedb.org/?seqid=P0ACF0 ProteinModelPortal P0ACF0 http://www.proteinmodelportal.org/query/uniprot/P0ACF0 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 215461 http://www.ncbi.nlm.nih.gov/pubmed/215461 PubMed 2187099 http://www.ncbi.nlm.nih.gov/pubmed/2187099 PubMed 21903814 http://www.ncbi.nlm.nih.gov/pubmed/21903814 PubMed 227733 http://www.ncbi.nlm.nih.gov/pubmed/227733 PubMed 3312963 http://www.ncbi.nlm.nih.gov/pubmed/3312963 PubMed 350619 http://www.ncbi.nlm.nih.gov/pubmed/350619 PubMed 6987059 http://www.ncbi.nlm.nih.gov/pubmed/6987059 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9868784 http://www.ncbi.nlm.nih.gov/pubmed/9868784 RefSeq NP_418428 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418428 RefSeq WP_001044513 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001044513 SMART SM00411 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00411 SMR P0ACF0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACF0 STRING 511145.b4000 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4000&targetmode=cogs STRING COG0776 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0776&targetmode=cogs SUPFAM SSF47729 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47729 UniProtKB DBHA_ECOLI http://www.uniprot.org/uniprot/DBHA_ECOLI UniProtKB-AC P0ACF0 http://www.uniprot.org/uniprot/P0ACF0 charge swissprot:DBHA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DBHA_ECOLI eggNOG COG0776 http://eggnogapi.embl.de/nog_data/html/tree/COG0776 eggNOG ENOG4105K70 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K70 epestfind swissprot:DBHA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DBHA_ECOLI garnier swissprot:DBHA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DBHA_ECOLI helixturnhelix swissprot:DBHA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DBHA_ECOLI hmoment swissprot:DBHA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DBHA_ECOLI iep swissprot:DBHA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DBHA_ECOLI inforesidue swissprot:DBHA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DBHA_ECOLI octanol swissprot:DBHA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DBHA_ECOLI pepcoil swissprot:DBHA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DBHA_ECOLI pepdigest swissprot:DBHA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DBHA_ECOLI pepinfo swissprot:DBHA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DBHA_ECOLI pepnet swissprot:DBHA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DBHA_ECOLI pepstats swissprot:DBHA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DBHA_ECOLI pepwheel swissprot:DBHA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DBHA_ECOLI pepwindow swissprot:DBHA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DBHA_ECOLI sigcleave swissprot:DBHA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DBHA_ECOLI ## Database ID URL or Descriptions # Organism YUAA_ECOLI Escherichia coli (strain K12) # RecName YUAA_ECOLI Uncharacterized protein YuaA # RefSeq NP_061382 NC_002483.1 # RefSeq WP_001336433 NC_002483.1 BLAST swissprot:YUAA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YUAA_ECOLI EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1263579 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263579 PSORT swissprot:YUAA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YUAA_ECOLI PSORT-B swissprot:YUAA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YUAA_ECOLI PSORT2 swissprot:YUAA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YUAA_ECOLI Phobius swissprot:YUAA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YUAA_ECOLI ProteinModelPortal Q9JMT9 http://www.proteinmodelportal.org/query/uniprot/Q9JMT9 RefSeq NP_061382 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061382 RefSeq WP_001336433 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001336433 UniProtKB YUAA_ECOLI http://www.uniprot.org/uniprot/YUAA_ECOLI UniProtKB-AC Q9JMT9 http://www.uniprot.org/uniprot/Q9JMT9 charge swissprot:YUAA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YUAA_ECOLI epestfind swissprot:YUAA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YUAA_ECOLI garnier swissprot:YUAA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YUAA_ECOLI helixturnhelix swissprot:YUAA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YUAA_ECOLI hmoment swissprot:YUAA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YUAA_ECOLI iep swissprot:YUAA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YUAA_ECOLI inforesidue swissprot:YUAA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YUAA_ECOLI octanol swissprot:YUAA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YUAA_ECOLI pepcoil swissprot:YUAA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YUAA_ECOLI pepdigest swissprot:YUAA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YUAA_ECOLI pepinfo swissprot:YUAA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YUAA_ECOLI pepnet swissprot:YUAA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YUAA_ECOLI pepstats swissprot:YUAA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YUAA_ECOLI pepwheel swissprot:YUAA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YUAA_ECOLI pepwindow swissprot:YUAA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YUAA_ECOLI sigcleave swissprot:YUAA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YUAA_ECOLI ## Database ID URL or Descriptions # AltName 23S rRNA (adenine(2030)-N6)-methyltransferase {ECO:0000255|HAMAP-Rule MF_00934} # AltName 23S rRNA m6A2030 methyltransferase {ECO:0000255|HAMAP-Rule MF_00934} # BRENDA 2.1.1.266 2026 # BioGrid 4262505 7 # CATALYTIC ACTIVITY RLMJ_ECOLI S-adenosyl-L-methionine + adenine(2030) in 23S rRNA = S-adenosyl-L-homocysteine + N(6)-methyladenine(2030) in 23S rRNA. {ECO 0000255|HAMAP-Rule MF_00934, ECO 0000269|PubMed 22847818, ECO 0000269|PubMed 23945937}. # DISRUPTION PHENOTYPE RLMJ_ECOLI The inactivation of the this gene results in the complete loss of A2030 modification, but does not cause the accumulation of ribosome assembly intermediates. The phenotype of rlmJ knockout gene is very mild under various growth conditions and at the stationary phase, except for a small growth advantage at anaerobic conditions. Only minor changes in the total E.coli proteome can be observed in a cell devoid of the 23S rRNA nucleotide A2030 methylation (PubMed 22847818). Cells lacking this gene are unable to grow using DNA as a sole nutrition source (PubMed 16707682). {ECO 0000269|PubMed 16707682, ECO 0000269|PubMed 22847818}. # EcoGene EG12234 rlmJ # FUNCTION RLMJ_ECOLI Specifically methylates the adenine in position 2030 of 23S rRNA. Nascent 23S rRNA seems to be the natural substrate. Appears to be not necessary for ribosome assembly. Seems to be required for the utilization of extracellular DNA as the sole source of carbon and energy. {ECO 0000255|HAMAP-Rule MF_00934, ECO 0000269|PubMed 16707682, ECO 0000269|PubMed 22847818, ECO 0000269|PubMed 23945937}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003723 RNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008988 rRNA (adenine-N6-)-methyltransferase activity; IDA:UniProtKB. # GO_function GO:0036307 23S rRNA (adenine(2030)-N(6))-methyltransferase activity; IDA:EcoCyc. # GO_process GO:0015976 carbon utilization; IMP:EcoCyc. # GO_process GO:0070475 rRNA base methylation; IDA:UniProtKB. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.50.150 -; 1. # HAMAP MF_00934 23SrRNA_methyltr_J # IntAct P37634 20 # InterPro IPR002052 DNA_methylase_N6_adenine_CS # InterPro IPR007473 RlmJ # InterPro IPR029063 SAM-dependent_MTases # MISCELLANEOUS RLMJ_ECOLI Recombinant protein prefers protein-free 23S rRNA to ribonucleoprotein particles containing only part of the 50S subunit proteins and does not methylate the assembled 50S subunit (PubMed 22847818). Recognizes a minimal substrate corresponding to helix 72; this shows that RlmJ requires only a small hairpin for activity and this suggests that RlmJ can methylate A2030 before the 23S RNA is completely transcribed, processed and folded (PubMed 23945937). Cannot modify single-stranded DNA having the same sequence as H72 (PubMed 23945937). {ECO 0000305|PubMed 22847818, ECO 0000305|PubMed 23945937}. # Organism RLMJ_ECOLI Escherichia coli (strain K12) # PATRIC 32122448 VBIEscCol129921_3601 # PDB 4BLU X-ray; 1.85 A; A/B=1-280 # PDB 4BLV X-ray; 2.00 A; A/B=1-280 # PDB 4BLW X-ray; 1.95 A; A/B=1-280 # PIR S47719 S47719 # PROSITE PS00092 N6_MTASE; 2 # Pfam PF04378 RsmJ # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Ribosomal RNA large subunit methyltransferase J {ECO:0000255|HAMAP-Rule MF_00934} # RefSeq NP_417956 NC_000913.3 # RefSeq WP_001300574 NZ_LN832404.1 # SIMILARITY Belongs to the RlmJ family. {ECO:0000255|HAMAP- Rule MF_00934}. # SUBUNIT RLMJ_ECOLI Monomer. {ECO 0000255|HAMAP-Rule MF_00934, ECO 0000269|PubMed 23989148}. # SUPFAM SSF53335 SSF53335 # eggNOG COG2961 LUCA # eggNOG ENOG4105D6S Bacteria BLAST swissprot:RLMJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RLMJ_ECOLI BioCyc ECOL316407:JW3466-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3466-MONOMER BioCyc EcoCyc:EG12234-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12234-MONOMER BioCyc MetaCyc:EG12234-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12234-MONOMER COG COG2961 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2961 DIP DIP-12371N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12371N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1093/nar/gkt719 http://dx.doi.org/10.1093/nar/gkt719 DOI 10.1107/S1744309113020289 http://dx.doi.org/10.1107/S1744309113020289 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01974-05 http://dx.doi.org/10.1128/JB.01974-05 DOI 10.1261/rna.034207.112 http://dx.doi.org/10.1261/rna.034207.112 EC_number EC:2.1.1.266 {ECO:0000255|HAMAP-Rule:MF_00934} http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.266 {ECO:0000255|HAMAP-Rule:MF_00934} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.1.1.266 {ECO:0000255|HAMAP-Rule:MF_00934} http://enzyme.expasy.org/EC/2.1.1.266 {ECO:0000255|HAMAP-Rule:MF_00934} EchoBASE EB2146 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2146 EcoGene EG12234 http://www.ecogene.org/geneInfo.php?eg_id=EG12234 EnsemblBacteria AAC76524 http://www.ensemblgenomes.org/id/AAC76524 EnsemblBacteria AAC76524 http://www.ensemblgenomes.org/id/AAC76524 EnsemblBacteria BAE77795 http://www.ensemblgenomes.org/id/BAE77795 EnsemblBacteria BAE77795 http://www.ensemblgenomes.org/id/BAE77795 EnsemblBacteria BAE77795 http://www.ensemblgenomes.org/id/BAE77795 EnsemblBacteria b3499 http://www.ensemblgenomes.org/id/b3499 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0008988 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008988 GO_function GO:0036307 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036307 GO_process GO:0015976 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015976 GO_process GO:0070475 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070475 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 GeneID 948012 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948012 HAMAP MF_00934 http://hamap.expasy.org/unirule/MF_00934 HOGENOM HOG000262479 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000262479&db=HOGENOM6 InParanoid P37634 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37634 IntAct P37634 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37634* IntEnz 2.1.1.266 {ECO:0000255|HAMAP-Rule:MF_00934} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.266 {ECO:0000255|HAMAP-Rule:MF_00934} InterPro IPR002052 http://www.ebi.ac.uk/interpro/entry/IPR002052 InterPro IPR007473 http://www.ebi.ac.uk/interpro/entry/IPR007473 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 KEGG_Gene ecj:JW3466 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3466 KEGG_Gene eco:b3499 http://www.genome.jp/dbget-bin/www_bget?eco:b3499 KEGG_Orthology KO:K07115 http://www.genome.jp/dbget-bin/www_bget?KO:K07115 MINT MINT-1219143 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1219143 OMA TYAIWYP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TYAIWYP PDB 4BLU http://www.ebi.ac.uk/pdbe-srv/view/entry/4BLU PDB 4BLV http://www.ebi.ac.uk/pdbe-srv/view/entry/4BLV PDB 4BLW http://www.ebi.ac.uk/pdbe-srv/view/entry/4BLW PDBsum 4BLU http://www.ebi.ac.uk/pdbsum/4BLU PDBsum 4BLV http://www.ebi.ac.uk/pdbsum/4BLV PDBsum 4BLW http://www.ebi.ac.uk/pdbsum/4BLW PROSITE PS00092 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00092 PSORT swissprot:RLMJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RLMJ_ECOLI PSORT-B swissprot:RLMJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RLMJ_ECOLI PSORT2 swissprot:RLMJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RLMJ_ECOLI Pfam PF04378 http://pfam.xfam.org/family/PF04378 Phobius swissprot:RLMJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RLMJ_ECOLI PhylomeDB P37634 http://phylomedb.org/?seqid=P37634 ProteinModelPortal P37634 http://www.proteinmodelportal.org/query/uniprot/P37634 PubMed 16707682 http://www.ncbi.nlm.nih.gov/pubmed/16707682 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22847818 http://www.ncbi.nlm.nih.gov/pubmed/22847818 PubMed 23945937 http://www.ncbi.nlm.nih.gov/pubmed/23945937 PubMed 23989148 http://www.ncbi.nlm.nih.gov/pubmed/23989148 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417956 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417956 RefSeq WP_001300574 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300574 SMR P37634 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37634 STRING 511145.b3499 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3499&targetmode=cogs STRING COG2961 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2961&targetmode=cogs SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 UniProtKB RLMJ_ECOLI http://www.uniprot.org/uniprot/RLMJ_ECOLI UniProtKB-AC P37634 http://www.uniprot.org/uniprot/P37634 charge swissprot:RLMJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RLMJ_ECOLI eggNOG COG2961 http://eggnogapi.embl.de/nog_data/html/tree/COG2961 eggNOG ENOG4105D6S http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D6S epestfind swissprot:RLMJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RLMJ_ECOLI garnier swissprot:RLMJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RLMJ_ECOLI helixturnhelix swissprot:RLMJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RLMJ_ECOLI hmoment swissprot:RLMJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RLMJ_ECOLI iep swissprot:RLMJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RLMJ_ECOLI inforesidue swissprot:RLMJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RLMJ_ECOLI octanol swissprot:RLMJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RLMJ_ECOLI pepcoil swissprot:RLMJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RLMJ_ECOLI pepdigest swissprot:RLMJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RLMJ_ECOLI pepinfo swissprot:RLMJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RLMJ_ECOLI pepnet swissprot:RLMJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RLMJ_ECOLI pepstats swissprot:RLMJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RLMJ_ECOLI pepwheel swissprot:RLMJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RLMJ_ECOLI pepwindow swissprot:RLMJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RLMJ_ECOLI sigcleave swissprot:RLMJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RLMJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4260742 7 # CATALYTIC ACTIVITY ARGD_ECOLI N(2)-acetyl-L-ornithine + 2-oxoglutarate = N- acetyl-L-glutamate 5-semialdehyde + L-glutamate. {ECO 0000255|HAMAP-Rule MF_01107, ECO 0000269|PubMed 10074354}. # CATALYTIC ACTIVITY ARGD_ECOLI N-succinyl-L-2,6-diaminoheptanedioate + 2- oxoglutarate = N-succinyl-2-L-amino-6-oxoheptanedioate + L- glutamate. {ECO 0000255|HAMAP-Rule MF_01107, ECO 0000269|PubMed 10074354}. # CDD cd00610 OAT_like # COFACTOR ARGD_ECOLI Name=pyridoxal 5'-phosphate; Xref=ChEBI CHEBI 597326; Evidence={ECO 0000305|PubMed 10074354}; Note=Binds 1 pyridoxal phosphate per subunit. {ECO 0000305|PubMed 10074354}; # EcoGene EG10066 argD # FUNCTION ARGD_ECOLI Involved in both the arginine and lysine biosynthetic pathways. {ECO 0000255|HAMAP-Rule MF_01107, ECO 0000269|PubMed 10074354}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function ARGD_ECOLI GO 0003992 N2-acetyl-L-ornithine 2-oxoglutarate 5-aminotransferase activity; IDA EcoliWiki. # GO_function GO:0009016 succinyldiaminopimelate transaminase activity; IDA:EcoliWiki. # GO_function GO:0030170 pyridoxal phosphate binding; IBA:GO_Central. # GO_function GO:0042802 identical protein binding; IBA:GO_Central. # GO_process GO:0033359 lysine biosynthetic process via diaminopimelate and N-succinyl-2-amino-6-ketopimelate; IGI:EcoCyc. # GO_process GO:0042450 arginine biosynthetic process via ornithine; IGI:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.640.10 -; 1. # Gene3D 3.90.1150.10 -; 1. # HAMAP MF_01107 ArgD_aminotrans_3 # IntAct P18335 6 # InterPro IPR004636 AcOrn/SuccOrn_fam # InterPro IPR005814 Aminotrans_3 # InterPro IPR015421 PyrdxlP-dep_Trfase_major_sub1 # InterPro IPR015422 PyrdxlP-dep_Trfase_major_sub2 # InterPro IPR015424 PyrdxlP-dep_Trfase # InterPro IPR017652 Ac/SucOrn_transaminase_bac # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01007 Amino acid related enzymes # KEGG_Pathway ko00300 Lysine biosynthesis # KEGG_Pathway ko00330 Arginine and proline metabolism # MISCELLANEOUS ARGD_ECOLI The reaction catalyzed by ACOAT is highly reversible. This enzyme may also transaminate ornithine. # Organism ARGD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11986 PTHR11986 # PATHWAY ARGD_ECOLI Amino-acid biosynthesis; L-arginine biosynthesis; N(2)- acetyl-L-ornithine from L-glutamate step 4/4. {ECO 0000255|HAMAP- Rule MF_01107, ECO 0000269|PubMed 10074354}. # PATHWAY ARGD_ECOLI Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route) step 2/3. {ECO 0000255|HAMAP-Rule MF_01107, ECO 0000269|PubMed 10074354}. # PATRIC 32122152 VBIEscCol129921_3453 # PIR B65130 B65130 # PROSITE PS00600 AA_TRANSFER_CLASS_3 # Pfam PF00202 Aminotran_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Acetylornithine/succinyldiaminopimelate aminotransferase {ECO:0000255|HAMAP-Rule MF_01107} # RefSeq NP_417818 NC_000913.3 # RefSeq WP_000963792 NZ_LN832404.1 # SIMILARITY Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. {ECO:0000255|HAMAP- Rule MF_01107}. # SUBCELLULAR LOCATION ARGD_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Homodimer. {ECO 0000305}. # SUPFAM SSF53383 SSF53383 # TIGRFAMs TIGR00707 argD # TIGRFAMs TIGR03246 arg_catab_astC # UniPathway UPA00034 UER00020 # UniPathway UPA00068 UER00109 # eggNOG COG4992 LUCA # eggNOG ENOG4105C8Y Bacteria BLAST swissprot:ARGD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARGD_ECOLI BioCyc ECOL316407:JW3322-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3322-MONOMER BioCyc EcoCyc:ACETYLORNTRANSAM-MONOMER http://biocyc.org/getid?id=EcoCyc:ACETYLORNTRANSAM-MONOMER BioCyc MetaCyc:ACETYLORNTRANSAM-MONOMER http://biocyc.org/getid?id=MetaCyc:ACETYLORNTRANSAM-MONOMER COG COG4992 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4992 DIP DIP-9138N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9138N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1016/0378-1119(90)90440-3 http://dx.doi.org/10.1016/0378-1119(90)90440-3 DOI 10.1021/bi982574a http://dx.doi.org/10.1021/bi982574a DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.6.1.11 {ECO:0000255|HAMAP-Rule:MF_01107} http://www.genome.jp/dbget-bin/www_bget?EC:2.6.1.11 {ECO:0000255|HAMAP-Rule:MF_01107} EC_number EC:2.6.1.17 {ECO:0000255|HAMAP-Rule:MF_01107} http://www.genome.jp/dbget-bin/www_bget?EC:2.6.1.17 {ECO:0000255|HAMAP-Rule:MF_01107} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M32796 http://www.ebi.ac.uk/ena/data/view/M32796 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 2.6.1.11 {ECO:0000255|HAMAP-Rule:MF_01107} http://enzyme.expasy.org/EC/2.6.1.11 {ECO:0000255|HAMAP-Rule:MF_01107} ENZYME 2.6.1.17 {ECO:0000255|HAMAP-Rule:MF_01107} http://enzyme.expasy.org/EC/2.6.1.17 {ECO:0000255|HAMAP-Rule:MF_01107} EchoBASE EB0064 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0064 EcoGene EG10066 http://www.ecogene.org/geneInfo.php?eg_id=EG10066 EnsemblBacteria AAC76384 http://www.ensemblgenomes.org/id/AAC76384 EnsemblBacteria AAC76384 http://www.ensemblgenomes.org/id/AAC76384 EnsemblBacteria BAE77931 http://www.ensemblgenomes.org/id/BAE77931 EnsemblBacteria BAE77931 http://www.ensemblgenomes.org/id/BAE77931 EnsemblBacteria BAE77931 http://www.ensemblgenomes.org/id/BAE77931 EnsemblBacteria b3359 http://www.ensemblgenomes.org/id/b3359 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003992 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003992 GO_function GO:0009016 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009016 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0033359 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033359 GO_process GO:0042450 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042450 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.640.10 http://www.cathdb.info/version/latest/superfamily/3.40.640.10 Gene3D 3.90.1150.10 http://www.cathdb.info/version/latest/superfamily/3.90.1150.10 GeneID 947864 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947864 HAMAP MF_01107 http://hamap.expasy.org/unirule/MF_01107 HOGENOM HOG000020206 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000020206&db=HOGENOM6 InParanoid P18335 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P18335 IntAct P18335 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P18335* IntEnz 2.6.1.11 {ECO:0000255|HAMAP-Rule:MF_01107} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.6.1.11 {ECO:0000255|HAMAP-Rule:MF_01107} IntEnz 2.6.1.17 {ECO:0000255|HAMAP-Rule:MF_01107} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.6.1.17 {ECO:0000255|HAMAP-Rule:MF_01107} InterPro IPR004636 http://www.ebi.ac.uk/interpro/entry/IPR004636 InterPro IPR005814 http://www.ebi.ac.uk/interpro/entry/IPR005814 InterPro IPR015421 http://www.ebi.ac.uk/interpro/entry/IPR015421 InterPro IPR015422 http://www.ebi.ac.uk/interpro/entry/IPR015422 InterPro IPR015424 http://www.ebi.ac.uk/interpro/entry/IPR015424 InterPro IPR017652 http://www.ebi.ac.uk/interpro/entry/IPR017652 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Gene ecj:JW3322 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3322 KEGG_Gene eco:b3359 http://www.genome.jp/dbget-bin/www_bget?eco:b3359 KEGG_Orthology KO:K00821 http://www.genome.jp/dbget-bin/www_bget?KO:K00821 KEGG_Pathway ko00300 http://www.genome.jp/kegg-bin/show_pathway?ko00300 KEGG_Pathway ko00330 http://www.genome.jp/kegg-bin/show_pathway?ko00330 KEGG_Reaction rn:R02283 http://www.genome.jp/dbget-bin/www_bget?rn:R02283 KEGG_Reaction rn:R04475 http://www.genome.jp/dbget-bin/www_bget?rn:R04475 OMA DFEPLMP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DFEPLMP PANTHER PTHR11986 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11986 PROSITE PS00600 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00600 PSORT swissprot:ARGD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARGD_ECOLI PSORT-B swissprot:ARGD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARGD_ECOLI PSORT2 swissprot:ARGD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARGD_ECOLI Pfam PF00202 http://pfam.xfam.org/family/PF00202 Phobius swissprot:ARGD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARGD_ECOLI PhylomeDB P18335 http://phylomedb.org/?seqid=P18335 ProteinModelPortal P18335 http://www.proteinmodelportal.org/query/uniprot/P18335 PubMed 10074354 http://www.ncbi.nlm.nih.gov/pubmed/10074354 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2199330 http://www.ncbi.nlm.nih.gov/pubmed/2199330 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_417818 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417818 RefSeq WP_000963792 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000963792 SMR P18335 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P18335 STRING 511145.b3359 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3359&targetmode=cogs STRING COG4992 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4992&targetmode=cogs SUPFAM SSF53383 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53383 SWISS-2DPAGE P18335 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P18335 TIGRFAMs TIGR00707 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00707 TIGRFAMs TIGR03246 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03246 UniProtKB ARGD_ECOLI http://www.uniprot.org/uniprot/ARGD_ECOLI UniProtKB-AC P18335 http://www.uniprot.org/uniprot/P18335 charge swissprot:ARGD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARGD_ECOLI eggNOG COG4992 http://eggnogapi.embl.de/nog_data/html/tree/COG4992 eggNOG ENOG4105C8Y http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C8Y epestfind swissprot:ARGD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARGD_ECOLI garnier swissprot:ARGD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARGD_ECOLI helixturnhelix swissprot:ARGD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARGD_ECOLI hmoment swissprot:ARGD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARGD_ECOLI iep swissprot:ARGD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARGD_ECOLI inforesidue swissprot:ARGD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARGD_ECOLI octanol swissprot:ARGD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARGD_ECOLI pepcoil swissprot:ARGD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARGD_ECOLI pepdigest swissprot:ARGD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARGD_ECOLI pepinfo swissprot:ARGD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARGD_ECOLI pepnet swissprot:ARGD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARGD_ECOLI pepstats swissprot:ARGD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARGD_ECOLI pepwheel swissprot:ARGD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARGD_ECOLI pepwindow swissprot:ARGD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARGD_ECOLI sigcleave swissprot:ARGD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARGD_ECOLI ## Database ID URL or Descriptions # EcoGene EG14417 yoaI # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # Organism YOAI_ECOLI Escherichia coli (strain K12) # PATRIC 32118887 VBIEscCol129921_1861 # PIR D64939 D64939 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YOAI_ECOLI Uncharacterized protein YoaI # RefSeq NP_416302 NC_000913.3 # SUBCELLULAR LOCATION YOAI_ECOLI Membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. BLAST swissprot:YOAI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YOAI_ECOLI BioCyc ECOL316407:JW5885-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5885-MONOMER BioCyc EcoCyc:G6974-MONOMER http://biocyc.org/getid?id=EcoCyc:G6974-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14417 http://www.ecogene.org/geneInfo.php?eg_id=EG14417 EnsemblBacteria AAC74858 http://www.ensemblgenomes.org/id/AAC74858 EnsemblBacteria AAC74858 http://www.ensemblgenomes.org/id/AAC74858 EnsemblBacteria BAE76527 http://www.ensemblgenomes.org/id/BAE76527 EnsemblBacteria BAE76527 http://www.ensemblgenomes.org/id/BAE76527 EnsemblBacteria BAE76527 http://www.ensemblgenomes.org/id/BAE76527 EnsemblBacteria b1788 http://www.ensemblgenomes.org/id/b1788 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GeneID 946294 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946294 HOGENOM HOG000009483 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009483&db=HOGENOM6 KEGG_Gene ecj:JW5885 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5885 KEGG_Gene eco:b1788 http://www.genome.jp/dbget-bin/www_bget?eco:b1788 PSORT swissprot:YOAI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YOAI_ECOLI PSORT-B swissprot:YOAI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YOAI_ECOLI PSORT2 swissprot:YOAI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YOAI_ECOLI Phobius swissprot:YOAI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YOAI_ECOLI ProteinModelPortal P76239 http://www.proteinmodelportal.org/query/uniprot/P76239 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416302 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416302 STRING 511145.b1788 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1788&targetmode=cogs UniProtKB YOAI_ECOLI http://www.uniprot.org/uniprot/YOAI_ECOLI UniProtKB-AC P76239 http://www.uniprot.org/uniprot/P76239 charge swissprot:YOAI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YOAI_ECOLI epestfind swissprot:YOAI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YOAI_ECOLI garnier swissprot:YOAI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YOAI_ECOLI helixturnhelix swissprot:YOAI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YOAI_ECOLI hmoment swissprot:YOAI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YOAI_ECOLI iep swissprot:YOAI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YOAI_ECOLI inforesidue swissprot:YOAI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YOAI_ECOLI octanol swissprot:YOAI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YOAI_ECOLI pepcoil swissprot:YOAI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YOAI_ECOLI pepdigest swissprot:YOAI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YOAI_ECOLI pepinfo swissprot:YOAI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YOAI_ECOLI pepnet swissprot:YOAI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YOAI_ECOLI pepstats swissprot:YOAI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YOAI_ECOLI pepwheel swissprot:YOAI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YOAI_ECOLI pepwindow swissprot:YOAI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YOAI_ECOLI sigcleave swissprot:YOAI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YOAI_ECOLI ## Database ID URL or Descriptions # BioGrid 4263500 11 # CATALYTIC ACTIVITY CMOA_ECOLI Prephenate + S-adenosyl-L-methionine = phenylpyruvate + carboxy-S-adenosyl-L-methionine + H(2)O. {ECO 0000255|HAMAP-Rule MF_01589, ECO 0000269|PubMed 23676670}. # EcoGene EG14033 cmoA # FUNCTION CMOA_ECOLI Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM). {ECO 0000255|HAMAP-Rule MF_01589, ECO 0000269|PubMed 23676670}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008757 S-adenosylmethionine-dependent methyltransferase activity; IBA:GO_Central. # GO_function GO:0016743 carboxyl- or carbamoyltransferase activity; IEA:UniProtKB-HAMAP. # GO_function GO:1904047 S-adenosyl-L-methionine binding; IEA:UniProtKB-HAMAP. # GO_process GO:0002098 tRNA wobble uridine modification; IMP:EcoCyc. # GO_process GO:0032259 methylation; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.150 -; 1. # HAMAP MF_01589 Cx_SAM_synthase # IntAct P76290 6 # InterPro IPR005271 CmoA # InterPro IPR029063 SAM-dependent_MTases # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # MISCELLANEOUS Mechanistic analyses show the involvement of a unique ylide intermediate as the carboxyl acceptor in the conversion of SAM to Cx-SAM. {ECO:0000269|PubMed 23676670}. # Organism CMOA_ECOLI Escherichia coli (strain K12) # PATRIC 32119063 VBIEscCol129921_1949 # PDB 4GEK X-ray; 1.50 A; A/G=1-247 # PDB 4IWN X-ray; 1.73 A; A/B=19-247 # PIR F64949 F64949 # PIRSF PIRSF006325 MeTrfase_bac # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Carboxy-S-adenosyl-L-methionine synthase {ECO:0000255|HAMAP-Rule MF_01589, ECO:0000305} # RefSeq NP_416384 NC_000913.3 # RefSeq WP_000019590 NZ_LN832404.1 # SIMILARITY Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family. {ECO:0000255|HAMAP-Rule MF_01589, ECO:0000305}. # SUBUNIT CMOA_ECOLI Homodimer. {ECO 0000255|HAMAP-Rule MF_01589, ECO 0000269|PubMed 23695253}. # SUPFAM SSF53335 SSF53335 # TIGRFAMs TIGR00740 TIGR00740 # eggNOG COG0500 LUCA # eggNOG ENOG4105DA6 Bacteria BLAST swissprot:CMOA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CMOA_ECOLI BioCyc ECOL316407:JW1859-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1859-MONOMER BioCyc EcoCyc:G7020-MONOMER http://biocyc.org/getid?id=EcoCyc:G7020-MONOMER BioCyc MetaCyc:G7020-MONOMER http://biocyc.org/getid?id=MetaCyc:G7020-MONOMER COG COG0500 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0500 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature12180 http://dx.doi.org/10.1038/nature12180 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1107/S0907444913004939 http://dx.doi.org/10.1107/S0907444913004939 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.3.- {ECO:0000255|HAMAP-Rule:MF_01589, ECO:0000269|PubMed:23676670} http://www.genome.jp/dbget-bin/www_bget?EC:2.1.3.- {ECO:0000255|HAMAP-Rule:MF_01589, ECO:0000269|PubMed:23676670} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.1.3.- {ECO:0000255|HAMAP-Rule:MF_01589, ECO:0000269|PubMed:23676670} http://enzyme.expasy.org/EC/2.1.3.- {ECO:0000255|HAMAP-Rule:MF_01589, ECO:0000269|PubMed:23676670} EchoBASE EB3787 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3787 EcoGene EG14033 http://www.ecogene.org/geneInfo.php?eg_id=EG14033 EnsemblBacteria AAC74940 http://www.ensemblgenomes.org/id/AAC74940 EnsemblBacteria AAC74940 http://www.ensemblgenomes.org/id/AAC74940 EnsemblBacteria BAA15680 http://www.ensemblgenomes.org/id/BAA15680 EnsemblBacteria BAA15680 http://www.ensemblgenomes.org/id/BAA15680 EnsemblBacteria BAA15680 http://www.ensemblgenomes.org/id/BAA15680 EnsemblBacteria b1870 http://www.ensemblgenomes.org/id/b1870 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008757 GO_function GO:0016743 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016743 GO_function GO:1904047 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1904047 GO_process GO:0002098 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002098 GO_process GO:0032259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032259 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 GeneID 946380 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946380 HAMAP MF_01589 http://hamap.expasy.org/unirule/MF_01589 HOGENOM HOG000218457 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218457&db=HOGENOM6 InParanoid P76290 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76290 IntAct P76290 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76290* IntEnz 2.1.3.- {ECO:0000255|HAMAP-Rule:MF_01589, ECO:0000269|PubMed:23676670} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.3.- {ECO:0000255|HAMAP-Rule:MF_01589, ECO:0000269|PubMed:23676670} InterPro IPR005271 http://www.ebi.ac.uk/interpro/entry/IPR005271 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW1859 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1859 KEGG_Gene eco:b1870 http://www.genome.jp/dbget-bin/www_bget?eco:b1870 KEGG_Orthology KO:K15256 http://www.genome.jp/dbget-bin/www_bget?KO:K15256 MINT MINT-7290797 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-7290797 OMA MIELYYL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MIELYYL PDB 4GEK http://www.ebi.ac.uk/pdbe-srv/view/entry/4GEK PDB 4IWN http://www.ebi.ac.uk/pdbe-srv/view/entry/4IWN PDBsum 4GEK http://www.ebi.ac.uk/pdbsum/4GEK PDBsum 4IWN http://www.ebi.ac.uk/pdbsum/4IWN PSORT swissprot:CMOA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CMOA_ECOLI PSORT-B swissprot:CMOA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CMOA_ECOLI PSORT2 swissprot:CMOA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CMOA_ECOLI Phobius swissprot:CMOA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CMOA_ECOLI PhylomeDB P76290 http://phylomedb.org/?seqid=P76290 ProteinModelPortal P76290 http://www.proteinmodelportal.org/query/uniprot/P76290 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 23676670 http://www.ncbi.nlm.nih.gov/pubmed/23676670 PubMed 23695253 http://www.ncbi.nlm.nih.gov/pubmed/23695253 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416384 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416384 RefSeq WP_000019590 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000019590 SMR P76290 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76290 STRING 511145.b1870 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1870&targetmode=cogs STRING COG0500 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0500&targetmode=cogs SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 SWISS-2DPAGE P76290 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P76290 TIGRFAMs TIGR00740 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00740 UniProtKB CMOA_ECOLI http://www.uniprot.org/uniprot/CMOA_ECOLI UniProtKB-AC P76290 http://www.uniprot.org/uniprot/P76290 charge swissprot:CMOA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CMOA_ECOLI eggNOG COG0500 http://eggnogapi.embl.de/nog_data/html/tree/COG0500 eggNOG ENOG4105DA6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DA6 epestfind swissprot:CMOA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CMOA_ECOLI garnier swissprot:CMOA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CMOA_ECOLI helixturnhelix swissprot:CMOA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CMOA_ECOLI hmoment swissprot:CMOA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CMOA_ECOLI iep swissprot:CMOA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CMOA_ECOLI inforesidue swissprot:CMOA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CMOA_ECOLI octanol swissprot:CMOA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CMOA_ECOLI pepcoil swissprot:CMOA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CMOA_ECOLI pepdigest swissprot:CMOA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CMOA_ECOLI pepinfo swissprot:CMOA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CMOA_ECOLI pepnet swissprot:CMOA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CMOA_ECOLI pepstats swissprot:CMOA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CMOA_ECOLI pepwheel swissprot:CMOA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CMOA_ECOLI pepwindow swissprot:CMOA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CMOA_ECOLI sigcleave swissprot:CMOA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CMOA_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES SFGH1_ECOLI Kinetic parameters KM=0.41 mM for S-formylglutathione {ECO 0000269|PubMed 16567800}; KM=0.29 mM for pNP-acetate {ECO 0000269|PubMed 16567800}; KM=0.83 mM for pNP-propionate {ECO 0000269|PubMed 16567800}; KM=0.60 mM for S-lactoylglutathione {ECO 0000269|PubMed 16567800}; Vmax=55.0 umol/min/mg enzyme with S-formylglutathione as substrate {ECO 0000269|PubMed 16567800}; Vmax=0.58 umol/min/mg enzyme with pNP-acetate as substrate {ECO 0000269|PubMed 16567800}; Vmax=0.27 umol/min/mg enzyme with pNP-propionate as substrate {ECO 0000269|PubMed 16567800}; Vmax=0.09 umol/min/mg enzyme with S-lactoylglutathione as substrate {ECO 0000269|PubMed 16567800}; # BioGrid 4261809 10 # CATALYTIC ACTIVITY S-formylglutathione + H(2)O = glutathione + formate. {ECO:0000269|PubMed 16567800}. # ENZYME REGULATION Inhibited by the sulfhydryl inhibitors (N- ethylmaleimide, iodoacetate, ZnCl(2) and CuCl(2)). {ECO:0000269|PubMed 16567800}. # ESTHER ecoli-yaim A85-EsteraseD-FGH # EcoGene EG13295 frmB # FUNCTION SFGH1_ECOLI Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate. Shows also esterase activity against two pNP-esters (pNP- acetate and pNP-propionate), alpha-naphthyl acetate and lactoylglutathione. {ECO 0000269|PubMed 16567800}. # GO_function GO:0018738 S-formylglutathione hydrolase activity; IDA:EcoCyc. # GO_function GO:0052689 carboxylic ester hydrolase activity; IEA:UniProtKB-KW. # GO_process GO:0046292 formaldehyde metabolic process; IMP:EcoCyc. # GO_process GO:0046294 formaldehyde catabolic process; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.1820 -; 1. # INDUCTION SFGH1_ECOLI Induced by formaldehyde and repressed by FrmR. {ECO 0000269|PubMed 15466022, ECO 0000269|PubMed 16567800}. # IntAct P51025 5 # InterPro IPR000801 Esterase_put # InterPro IPR014186 S-formylglutathione_hydrol # InterPro IPR029058 AB_hydrolase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00680 Methane metabolism # Organism SFGH1_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10061 PTHR10061 # PATRIC 32115849 VBIEscCol129921_0366 # PIR C64763 C64763 # Pfam PF00756 Esterase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SFGH1_ECOLI S-formylglutathione hydrolase FrmB # RefSeq NP_414889 NC_000913.3 # RefSeq WP_000419081 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=D85613; Type=Frameshift; Positions=137; Evidence={ECO 0000305}; # SIMILARITY Belongs to the esterase D family. {ECO 0000305}. # SUPFAM SSF53474 SSF53474 # TIGRFAMs TIGR02821 fghA_ester_D # eggNOG COG0627 LUCA # eggNOG ENOG4105C4W Bacteria BLAST swissprot:SFGH1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SFGH1_ECOLI BioCyc ECOL316407:JW0346-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0346-MONOMER BioCyc EcoCyc:G6208-MONOMER http://biocyc.org/getid?id=EcoCyc:G6208-MONOMER BioCyc MetaCyc:G6208-MONOMER http://biocyc.org/getid?id=MetaCyc:G6208-MONOMER COG COG0627 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0627 DIP DIP-11274N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11274N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M600996200 http://dx.doi.org/10.1074/jbc.M600996200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.186.20.6714-6720.2004 http://dx.doi.org/10.1128/JB.186.20.6714-6720.2004 EC_number EC:3.1.2.12 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.2.12 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D85613 http://www.ebi.ac.uk/ena/data/view/D85613 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 ENZYME 3.1.2.12 http://enzyme.expasy.org/EC/3.1.2.12 EchoBASE EB3080 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3080 EcoGene EG13295 http://www.ecogene.org/geneInfo.php?eg_id=EG13295 EnsemblBacteria AAC73458 http://www.ensemblgenomes.org/id/AAC73458 EnsemblBacteria AAC73458 http://www.ensemblgenomes.org/id/AAC73458 EnsemblBacteria BAE76137 http://www.ensemblgenomes.org/id/BAE76137 EnsemblBacteria BAE76137 http://www.ensemblgenomes.org/id/BAE76137 EnsemblBacteria BAE76137 http://www.ensemblgenomes.org/id/BAE76137 EnsemblBacteria b0355 http://www.ensemblgenomes.org/id/b0355 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0018738 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018738 GO_function GO:0052689 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052689 GO_process GO:0046292 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046292 GO_process GO:0046294 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046294 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.1820 http://www.cathdb.info/version/latest/superfamily/3.40.50.1820 GeneID 944991 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944991 HOGENOM HOG000263929 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000263929&db=HOGENOM6 InParanoid P51025 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P51025 IntAct P51025 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P51025* IntEnz 3.1.2.12 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.2.12 InterPro IPR000801 http://www.ebi.ac.uk/interpro/entry/IPR000801 InterPro IPR014186 http://www.ebi.ac.uk/interpro/entry/IPR014186 InterPro IPR029058 http://www.ebi.ac.uk/interpro/entry/IPR029058 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0346 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0346 KEGG_Gene eco:b0355 http://www.genome.jp/dbget-bin/www_bget?eco:b0355 KEGG_Orthology KO:K01070 http://www.genome.jp/dbget-bin/www_bget?KO:K01070 KEGG_Pathway ko00680 http://www.genome.jp/kegg-bin/show_pathway?ko00680 KEGG_Reaction rn:R00527 http://www.genome.jp/dbget-bin/www_bget?rn:R00527 OMA KWHAERL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KWHAERL PANTHER PTHR10061 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10061 PSORT swissprot:SFGH1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SFGH1_ECOLI PSORT-B swissprot:SFGH1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SFGH1_ECOLI PSORT2 swissprot:SFGH1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SFGH1_ECOLI Pfam PF00756 http://pfam.xfam.org/family/PF00756 Phobius swissprot:SFGH1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SFGH1_ECOLI PhylomeDB P51025 http://phylomedb.org/?seqid=P51025 ProteinModelPortal P51025 http://www.proteinmodelportal.org/query/uniprot/P51025 PubMed 15466022 http://www.ncbi.nlm.nih.gov/pubmed/15466022 PubMed 16567800 http://www.ncbi.nlm.nih.gov/pubmed/16567800 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414889 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414889 RefSeq WP_000419081 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000419081 SMR P51025 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P51025 STRING 511145.b0355 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0355&targetmode=cogs STRING COG0627 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0627&targetmode=cogs SUPFAM SSF53474 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53474 TIGRFAMs TIGR02821 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02821 UniProtKB SFGH1_ECOLI http://www.uniprot.org/uniprot/SFGH1_ECOLI UniProtKB-AC P51025 http://www.uniprot.org/uniprot/P51025 charge swissprot:SFGH1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SFGH1_ECOLI eggNOG COG0627 http://eggnogapi.embl.de/nog_data/html/tree/COG0627 eggNOG ENOG4105C4W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C4W epestfind swissprot:SFGH1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SFGH1_ECOLI garnier swissprot:SFGH1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SFGH1_ECOLI helixturnhelix swissprot:SFGH1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SFGH1_ECOLI hmoment swissprot:SFGH1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SFGH1_ECOLI iep swissprot:SFGH1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SFGH1_ECOLI inforesidue swissprot:SFGH1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SFGH1_ECOLI octanol swissprot:SFGH1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SFGH1_ECOLI pepcoil swissprot:SFGH1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SFGH1_ECOLI pepdigest swissprot:SFGH1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SFGH1_ECOLI pepinfo swissprot:SFGH1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SFGH1_ECOLI pepnet swissprot:SFGH1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SFGH1_ECOLI pepstats swissprot:SFGH1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SFGH1_ECOLI pepwheel swissprot:SFGH1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SFGH1_ECOLI pepwindow swissprot:SFGH1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SFGH1_ECOLI sigcleave swissprot:SFGH1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SFGH1_ECOLI ## Database ID URL or Descriptions # BioGrid 4259563 143 # EcoGene EG13755 ydcL # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GOslim_component GO:0005886 plasma membrane # InterPro IPR021747 DUF3313 # Organism YDCL_ECOLI Escherichia coli (strain K12) # PATRIC 32118148 VBIEscCol129921_1494 # PIR B64895 B64895 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF11769 DUF3313 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDCL_ECOLI Uncharacterized lipoprotein YdcL # RefSeq NP_415948 NC_000913.3 # RefSeq WP_001261013 NZ_LN832404.1 # SUBCELLULAR LOCATION YDCL_ECOLI Cell membrane {ECO 0000305}; Lipid-anchor {ECO 0000305}. # eggNOG ENOG4108KKZ Bacteria # eggNOG ENOG410Z8VE LUCA BLAST swissprot:YDCL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDCL_ECOLI BioCyc ECOL316407:JW1427-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1427-MONOMER BioCyc EcoCyc:G6742-MONOMER http://biocyc.org/getid?id=EcoCyc:G6742-MONOMER DIP DIP-47883N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47883N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3518 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3518 EcoGene EG13755 http://www.ecogene.org/geneInfo.php?eg_id=EG13755 EnsemblBacteria AAC74513 http://www.ensemblgenomes.org/id/AAC74513 EnsemblBacteria AAC74513 http://www.ensemblgenomes.org/id/AAC74513 EnsemblBacteria BAE76436 http://www.ensemblgenomes.org/id/BAE76436 EnsemblBacteria BAE76436 http://www.ensemblgenomes.org/id/BAE76436 EnsemblBacteria BAE76436 http://www.ensemblgenomes.org/id/BAE76436 EnsemblBacteria b1431 http://www.ensemblgenomes.org/id/b1431 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 948203 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948203 HOGENOM HOG000120597 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120597&db=HOGENOM6 InterPro IPR021747 http://www.ebi.ac.uk/interpro/entry/IPR021747 KEGG_Gene ecj:JW1427 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1427 KEGG_Gene eco:b1431 http://www.genome.jp/dbget-bin/www_bget?eco:b1431 OMA MRWIDPK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MRWIDPK PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YDCL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDCL_ECOLI PSORT-B swissprot:YDCL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDCL_ECOLI PSORT2 swissprot:YDCL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDCL_ECOLI Pfam PF11769 http://pfam.xfam.org/family/PF11769 Phobius swissprot:YDCL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDCL_ECOLI ProteinModelPortal P64451 http://www.proteinmodelportal.org/query/uniprot/P64451 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415948 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415948 RefSeq WP_001261013 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001261013 STRING 511145.b1431 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1431&targetmode=cogs UniProtKB YDCL_ECOLI http://www.uniprot.org/uniprot/YDCL_ECOLI UniProtKB-AC P64451 http://www.uniprot.org/uniprot/P64451 charge swissprot:YDCL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDCL_ECOLI eggNOG ENOG4108KKZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108KKZ eggNOG ENOG410Z8VE http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Z8VE epestfind swissprot:YDCL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDCL_ECOLI garnier swissprot:YDCL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDCL_ECOLI helixturnhelix swissprot:YDCL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDCL_ECOLI hmoment swissprot:YDCL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDCL_ECOLI iep swissprot:YDCL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDCL_ECOLI inforesidue swissprot:YDCL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDCL_ECOLI octanol swissprot:YDCL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDCL_ECOLI pepcoil swissprot:YDCL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDCL_ECOLI pepdigest swissprot:YDCL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDCL_ECOLI pepinfo swissprot:YDCL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDCL_ECOLI pepnet swissprot:YDCL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDCL_ECOLI pepstats swissprot:YDCL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDCL_ECOLI pepwheel swissprot:YDCL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDCL_ECOLI pepwindow swissprot:YDCL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDCL_ECOLI sigcleave swissprot:YDCL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDCL_ECOLI ## Database ID URL or Descriptions # BioGrid 4261546 7 # EcoGene EG13182 ydbJ # InterPro IPR005590 DUF333 # Organism YDBJ_ECOLI Escherichia coli (strain K12) # PATRIC 32118042 VBIEscCol129921_1441 # Pfam PF03891 DUF333 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDBJ_ECOLI Uncharacterized protein YdbJ # RefSeq WP_001295715 NZ_LN832404.1 # RefSeq YP_588453 NC_000913.3 # eggNOG COG3042 LUCA # eggNOG ENOG4105IKK Bacteria BLAST swissprot:YDBJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDBJ_ECOLI BioCyc ECOL316407:JW5215-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5215-MONOMER BioCyc EcoCyc:MONOMER0-2672 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2672 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1099/00221287-143-1-187 http://dx.doi.org/10.1099/00221287-143-1-187 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36928 http://www.ebi.ac.uk/ena/data/view/U36928 EchoBASE EB2974 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2974 EcoGene EG13182 http://www.ecogene.org/geneInfo.php?eg_id=EG13182 EnsemblBacteria ABD18661 http://www.ensemblgenomes.org/id/ABD18661 EnsemblBacteria ABD18661 http://www.ensemblgenomes.org/id/ABD18661 EnsemblBacteria BAA14983 http://www.ensemblgenomes.org/id/BAA14983 EnsemblBacteria BAA14983 http://www.ensemblgenomes.org/id/BAA14983 EnsemblBacteria BAA14983 http://www.ensemblgenomes.org/id/BAA14983 EnsemblBacteria b4529 http://www.ensemblgenomes.org/id/b4529 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 4056027 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4056027 HOGENOM HOG000219348 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219348&db=HOGENOM6 InterPro IPR005590 http://www.ebi.ac.uk/interpro/entry/IPR005590 KEGG_Gene ecj:JW5215 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5215 KEGG_Gene eco:b4529 http://www.genome.jp/dbget-bin/www_bget?eco:b4529 OMA GRRCDEQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GRRCDEQ PSORT swissprot:YDBJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDBJ_ECOLI PSORT-B swissprot:YDBJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDBJ_ECOLI PSORT2 swissprot:YDBJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDBJ_ECOLI Pfam PF03891 http://pfam.xfam.org/family/PF03891 Phobius swissprot:YDBJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDBJ_ECOLI ProteinModelPortal P0ACW2 http://www.proteinmodelportal.org/query/uniprot/P0ACW2 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9025293 http://www.ncbi.nlm.nih.gov/pubmed/9025293 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001295715 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295715 RefSeq YP_588453 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_588453 STRING 511145.b4529 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4529&targetmode=cogs UniProtKB YDBJ_ECOLI http://www.uniprot.org/uniprot/YDBJ_ECOLI UniProtKB-AC P0ACW2 http://www.uniprot.org/uniprot/P0ACW2 charge swissprot:YDBJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDBJ_ECOLI eggNOG COG3042 http://eggnogapi.embl.de/nog_data/html/tree/COG3042 eggNOG ENOG4105IKK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105IKK epestfind swissprot:YDBJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDBJ_ECOLI garnier swissprot:YDBJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDBJ_ECOLI helixturnhelix swissprot:YDBJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDBJ_ECOLI hmoment swissprot:YDBJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDBJ_ECOLI iep swissprot:YDBJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDBJ_ECOLI inforesidue swissprot:YDBJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDBJ_ECOLI octanol swissprot:YDBJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDBJ_ECOLI pepcoil swissprot:YDBJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDBJ_ECOLI pepdigest swissprot:YDBJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDBJ_ECOLI pepinfo swissprot:YDBJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDBJ_ECOLI pepnet swissprot:YDBJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDBJ_ECOLI pepstats swissprot:YDBJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDBJ_ECOLI pepwheel swissprot:YDBJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDBJ_ECOLI pepwindow swissprot:YDBJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDBJ_ECOLI sigcleave swissprot:YDBJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDBJ_ECOLI ## Database ID URL or Descriptions # AltName MELB_ECOLI Melibiose permease # AltName MELB_ECOLI Melibiose transporter # AltName MELB_ECOLI Na+ (Li+)/melibiose symporter # AltName MELB_ECOLI Thiomethylgalactoside permease II # BioGrid 4263176 14 # EcoGene EG10578 melB # FUNCTION MELB_ECOLI Responsible for melibiose and other galactoside transport. It is capable of using hydrogen, sodium, and lithium cations as coupling cations for cotransport, depending on the particular sugar transported (symport system). # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_function GO:0015592 methylgalactoside transmembrane transporter activity; IDA:EcoCyc. # GO_function MELB_ECOLI GO 0015487 melibiose monovalent cation symporter activity; IDA EcoCyc. # GO_function MELB_ECOLI GO 0043887 melibiose sodium symporter activity; IDA EcoCyc. # GO_process GO:0015765 methylgalactoside transport; IDA:EcoCyc. # GO_process GO:0015769 melibiose transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR001927 Na/Gal_symport # InterPro IPR018043 Na/Gal_symport_CS # InterPro IPR020846 MFS_dom # KEGG_Brite ko02000 Transporters # Organism MELB_ECOLI Escherichia coli (strain K12) # PATRIC 32123805 VBIEscCol129921_4251 # PIR A03421 BDEC # PROSITE PS00872 NA_GALACTOSIDE_SYMP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MELB_ECOLI Melibiose carrier protein # RefSeq NP_418544 NC_000913.3 # RefSeq WP_000028111 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA24148.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAA97020.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=BAE78122.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; # SIMILARITY Belongs to the sodium:galactoside symporter (TC 2.A.2) family. {ECO 0000305}. # SUBCELLULAR LOCATION MELB_ECOLI Cell inner membrane {ECO 0000269|PubMed 7703254}; Multi-pass membrane protein {ECO 0000269|PubMed 7703254}. # SUBUNIT Monomer and homodimer. {ECO:0000269|PubMed 7703254}. # SUPFAM SSF103473 SSF103473 # TIGRFAMs TIGR00792 gph # eggNOG COG2211 LUCA # eggNOG ENOG4105CT4 Bacteria BLAST swissprot:MELB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MELB_ECOLI BioCyc ECOL316407:JW4081-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4081-MONOMER BioCyc EcoCyc:MELB-MONOMER http://biocyc.org/getid?id=EcoCyc:MELB-MONOMER BioCyc MetaCyc:MELB-MONOMER http://biocyc.org/getid?id=MetaCyc:MELB-MONOMER COG COG2211 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2211 DIP DIP-10180N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10180N DOI 10.1016/0006-291X(91)91016-6 http://dx.doi.org/10.1016/0006-291X(91)91016-6 DOI 10.1021/bi00013a033 http://dx.doi.org/10.1021/bi00013a033 DOI 10.1021/bi9527496 http://dx.doi.org/10.1021/bi9527496 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0905516106 http://dx.doi.org/10.1073/pnas.0905516106 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K01991 http://www.ebi.ac.uk/ena/data/view/K01991 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB0573 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0573 EcoGene EG10578 http://www.ecogene.org/geneInfo.php?eg_id=EG10578 EnsemblBacteria AAC77081 http://www.ensemblgenomes.org/id/AAC77081 EnsemblBacteria AAC77081 http://www.ensemblgenomes.org/id/AAC77081 EnsemblBacteria BAE78122 http://www.ensemblgenomes.org/id/BAE78122 EnsemblBacteria BAE78122 http://www.ensemblgenomes.org/id/BAE78122 EnsemblBacteria BAE78122 http://www.ensemblgenomes.org/id/BAE78122 EnsemblBacteria b4120 http://www.ensemblgenomes.org/id/b4120 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015487 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015487 GO_function GO:0015592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015592 GO_function GO:0043887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043887 GO_process GO:0015765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015765 GO_process GO:0015769 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015769 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948635 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948635 HOGENOM HOG000294602 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000294602&db=HOGENOM6 InParanoid P02921 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P02921 IntAct P02921 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P02921* InterPro IPR001927 http://www.ebi.ac.uk/interpro/entry/IPR001927 InterPro IPR018043 http://www.ebi.ac.uk/interpro/entry/IPR018043 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW4081 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4081 KEGG_Gene eco:b4120 http://www.genome.jp/dbget-bin/www_bget?eco:b4120 KEGG_Orthology KO:K11104 http://www.genome.jp/dbget-bin/www_bget?KO:K11104 MINT MINT-1320140 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1320140 PROSITE PS00872 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00872 PSORT swissprot:MELB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MELB_ECOLI PSORT-B swissprot:MELB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MELB_ECOLI PSORT2 swissprot:MELB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MELB_ECOLI Phobius swissprot:MELB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MELB_ECOLI ProteinModelPortal P02921 http://www.proteinmodelportal.org/query/uniprot/P02921 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1730719 http://www.ncbi.nlm.nih.gov/pubmed/1730719 PubMed 1872836 http://www.ncbi.nlm.nih.gov/pubmed/1872836 PubMed 19706416 http://www.ncbi.nlm.nih.gov/pubmed/19706416 PubMed 6323466 http://www.ncbi.nlm.nih.gov/pubmed/6323466 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 7703254 http://www.ncbi.nlm.nih.gov/pubmed/7703254 PubMed 8672452 http://www.ncbi.nlm.nih.gov/pubmed/8672452 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418544 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418544 RefSeq WP_000028111 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000028111 STRING 511145.b4120 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4120&targetmode=cogs STRING COG2211 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2211&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TIGRFAMs TIGR00792 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00792 UniProtKB MELB_ECOLI http://www.uniprot.org/uniprot/MELB_ECOLI UniProtKB-AC P02921 http://www.uniprot.org/uniprot/P02921 charge swissprot:MELB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MELB_ECOLI eggNOG COG2211 http://eggnogapi.embl.de/nog_data/html/tree/COG2211 eggNOG ENOG4105CT4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CT4 epestfind swissprot:MELB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MELB_ECOLI garnier swissprot:MELB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MELB_ECOLI helixturnhelix swissprot:MELB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MELB_ECOLI hmoment swissprot:MELB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MELB_ECOLI iep swissprot:MELB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MELB_ECOLI inforesidue swissprot:MELB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MELB_ECOLI octanol swissprot:MELB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MELB_ECOLI pepcoil swissprot:MELB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MELB_ECOLI pepdigest swissprot:MELB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MELB_ECOLI pepinfo swissprot:MELB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MELB_ECOLI pepnet swissprot:MELB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MELB_ECOLI pepstats swissprot:MELB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MELB_ECOLI pepwheel swissprot:MELB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MELB_ECOLI pepwindow swissprot:MELB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MELB_ECOLI sigcleave swissprot:MELB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MELB_ECOLI ## Database ID URL or Descriptions # BioGrid 4261903 15 # EcoGene EG13651 ybeU # InterPro IPR009677 DUF1266 # Organism YBEU_ECOLI Escherichia coli (strain K12) # PATRIC 32116479 VBIEscCol129921_0679 # PIR F64799 F64799 # Pfam PF06889 DUF1266 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBEU_ECOLI Uncharacterized protein YbeU # RefSeq NP_415181 NC_000913.3 # RefSeq WP_001030934 NZ_LN832404.1 # SIMILARITY To E.coli YbeR. {ECO 0000305}. # eggNOG ENOG41069CF Bacteria # eggNOG ENOG410XVCG LUCA BLAST swissprot:YBEU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBEU_ECOLI BioCyc ECOL316407:JW0643-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0643-MONOMER BioCyc EcoCyc:G6355-MONOMER http://biocyc.org/getid?id=EcoCyc:G6355-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB3415 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3415 EcoGene EG13651 http://www.ecogene.org/geneInfo.php?eg_id=EG13651 EnsemblBacteria AAC73749 http://www.ensemblgenomes.org/id/AAC73749 EnsemblBacteria AAC73749 http://www.ensemblgenomes.org/id/AAC73749 EnsemblBacteria BAA35295 http://www.ensemblgenomes.org/id/BAA35295 EnsemblBacteria BAA35295 http://www.ensemblgenomes.org/id/BAA35295 EnsemblBacteria BAA35295 http://www.ensemblgenomes.org/id/BAA35295 EnsemblBacteria b0648 http://www.ensemblgenomes.org/id/b0648 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945244 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945244 HOGENOM HOG000009368 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009368&db=HOGENOM6 InParanoid P77427 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77427 InterPro IPR009677 http://www.ebi.ac.uk/interpro/entry/IPR009677 KEGG_Gene ecj:JW0643 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0643 KEGG_Gene eco:b0648 http://www.genome.jp/dbget-bin/www_bget?eco:b0648 OMA HCANQSE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HCANQSE PSORT swissprot:YBEU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBEU_ECOLI PSORT-B swissprot:YBEU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBEU_ECOLI PSORT2 swissprot:YBEU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBEU_ECOLI Pfam PF06889 http://pfam.xfam.org/family/PF06889 Phobius swissprot:YBEU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBEU_ECOLI PhylomeDB P77427 http://phylomedb.org/?seqid=P77427 ProteinModelPortal P77427 http://www.proteinmodelportal.org/query/uniprot/P77427 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415181 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415181 RefSeq WP_001030934 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001030934 STRING 511145.b0648 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0648&targetmode=cogs UniProtKB YBEU_ECOLI http://www.uniprot.org/uniprot/YBEU_ECOLI UniProtKB-AC P77427 http://www.uniprot.org/uniprot/P77427 charge swissprot:YBEU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBEU_ECOLI eggNOG ENOG41069CF http://eggnogapi.embl.de/nog_data/html/tree/ENOG41069CF eggNOG ENOG410XVCG http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XVCG epestfind swissprot:YBEU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBEU_ECOLI garnier swissprot:YBEU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBEU_ECOLI helixturnhelix swissprot:YBEU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBEU_ECOLI hmoment swissprot:YBEU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBEU_ECOLI iep swissprot:YBEU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBEU_ECOLI inforesidue swissprot:YBEU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBEU_ECOLI octanol swissprot:YBEU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBEU_ECOLI pepcoil swissprot:YBEU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBEU_ECOLI pepdigest swissprot:YBEU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBEU_ECOLI pepinfo swissprot:YBEU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBEU_ECOLI pepnet swissprot:YBEU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBEU_ECOLI pepstats swissprot:YBEU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBEU_ECOLI pepwheel swissprot:YBEU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBEU_ECOLI pepwindow swissprot:YBEU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBEU_ECOLI sigcleave swissprot:YBEU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBEU_ECOLI ## Database ID URL or Descriptions # BioGrid 4263070 103 # DISRUPTION PHENOTYPE Not required for motility, disruption leads to derepression of the adhesive curli fimbriae genes. {ECO:0000269|PubMed 18765794}. # EcoGene EG11356 fliZ # FUNCTION FLIZ_ECOLI During the post-exponential growth phase transiently interferes with RpoS (sigma S) activity without affecting expression of RpoS itself. It is probably not an anti-sigma factor as its overexpression is detrimental in rapidly growing cells where there is almost no sigma S factor. There is a strong overlap between Crl-activated genes and FliZ-down-regulated genes. FliZ acts as a timing device for expression of the genes for the adhesive curli fimbriae by indirectly decreasing expression of the curli regulator CsgD. {ECO 0000269|PubMed 18765794}. # GO_function GO:0001047 core promoter binding; IDA:EcoCyc. # GO_function GO:0016989 sigma factor antagonist activity; IMP:EcoCyc. # GO_process GO:0015074 DNA integration; IEA:InterPro. # GO_process GO:1902021 regulation of bacterial-type flagellum-dependent cell motility; IMP:EcoCyc. # GOslim_function GO:0000988 transcription factor activity, protein binding # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0008150 biological_process # INDUCTION Induced in early post-exponential phase, its expression decreases again at OD578 2-2.5. {ECO:0000269|PubMed 18765794}. # IntAct P52627 7 # InterPro IPR004107 Integrase_SAM-like_N # InterPro IPR022523 Flagellar_regulator_FliZ # KEGG_Brite ko02035 Bacterial motility proteins # Organism FLIZ_ECOLI Escherichia coli (strain K12) # PATRIC 32119177 VBIEscCol129921_2003 # PIR F64955 F64955 # Pfam PF02899 Phage_int_SAM_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FLIZ_ECOLI Regulator of sigma S factor FliZ # RefSeq NP_416431 NC_000913.3 # RefSeq WP_001350518 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAC43544.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # TIGRFAMs TIGR03823 FliZ # eggNOG ENOG4108M9K Bacteria # eggNOG ENOG4111I0Y LUCA BLAST swissprot:FLIZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLIZ_ECOLI BioCyc ECOL316407:JW1906-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1906-MONOMER BioCyc EcoCyc:EG11356-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11356-MONOMER DOI 10.1016/0378-1119(95)00480-T http://dx.doi.org/10.1016/0378-1119(95)00480-T DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1101/gad.475808 http://dx.doi.org/10.1101/gad.475808 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L36677 http://www.ebi.ac.uk/ena/data/view/L36677 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18539 http://www.ebi.ac.uk/ena/data/view/U18539 EchoBASE EB1331 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1331 EcoGene EG11356 http://www.ecogene.org/geneInfo.php?eg_id=EG11356 EnsemblBacteria AAC74988 http://www.ensemblgenomes.org/id/AAC74988 EnsemblBacteria AAC74988 http://www.ensemblgenomes.org/id/AAC74988 EnsemblBacteria BAA15741 http://www.ensemblgenomes.org/id/BAA15741 EnsemblBacteria BAA15741 http://www.ensemblgenomes.org/id/BAA15741 EnsemblBacteria BAA15741 http://www.ensemblgenomes.org/id/BAA15741 EnsemblBacteria b1921 http://www.ensemblgenomes.org/id/b1921 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0001047 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001047 GO_function GO:0016989 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016989 GO_process GO:0015074 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015074 GO_process GO:1902021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902021 GOslim_function GO:0000988 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000988 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 946833 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946833 HOGENOM HOG000121298 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000121298&db=HOGENOM6 IntAct P52627 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P52627* InterPro IPR004107 http://www.ebi.ac.uk/interpro/entry/IPR004107 InterPro IPR022523 http://www.ebi.ac.uk/interpro/entry/IPR022523 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW1906 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1906 KEGG_Gene eco:b1921 http://www.genome.jp/dbget-bin/www_bget?eco:b1921 KEGG_Orthology KO:K02425 http://www.genome.jp/dbget-bin/www_bget?KO:K02425 OMA LHCKEQS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LHCKEQS PSORT swissprot:FLIZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLIZ_ECOLI PSORT-B swissprot:FLIZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLIZ_ECOLI PSORT2 swissprot:FLIZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLIZ_ECOLI Pfam PF02899 http://pfam.xfam.org/family/PF02899 Phobius swissprot:FLIZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLIZ_ECOLI ProteinModelPortal P52627 http://www.proteinmodelportal.org/query/uniprot/P52627 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18765794 http://www.ncbi.nlm.nih.gov/pubmed/18765794 PubMed 7590326 http://www.ncbi.nlm.nih.gov/pubmed/7590326 PubMed 8550423 http://www.ncbi.nlm.nih.gov/pubmed/8550423 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416431 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416431 RefSeq WP_001350518 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001350518 STRING 511145.b1921 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1921&targetmode=cogs TIGRFAMs TIGR03823 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03823 UniProtKB FLIZ_ECOLI http://www.uniprot.org/uniprot/FLIZ_ECOLI UniProtKB-AC P52627 http://www.uniprot.org/uniprot/P52627 charge swissprot:FLIZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLIZ_ECOLI eggNOG ENOG4108M9K http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108M9K eggNOG ENOG4111I0Y http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111I0Y epestfind swissprot:FLIZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLIZ_ECOLI garnier swissprot:FLIZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLIZ_ECOLI helixturnhelix swissprot:FLIZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLIZ_ECOLI hmoment swissprot:FLIZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLIZ_ECOLI iep swissprot:FLIZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLIZ_ECOLI inforesidue swissprot:FLIZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLIZ_ECOLI octanol swissprot:FLIZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLIZ_ECOLI pepcoil swissprot:FLIZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLIZ_ECOLI pepdigest swissprot:FLIZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLIZ_ECOLI pepinfo swissprot:FLIZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLIZ_ECOLI pepnet swissprot:FLIZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLIZ_ECOLI pepstats swissprot:FLIZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLIZ_ECOLI pepwheel swissprot:FLIZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLIZ_ECOLI pepwindow swissprot:FLIZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLIZ_ECOLI sigcleave swissprot:FLIZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLIZ_ECOLI ## Database ID URL or Descriptions # AltName ALLB_ECOLI Allantoin-utilizing enzyme # BIOPHYSICOCHEMICAL PROPERTIES ALLB_ECOLI Kinetic parameters KM=4.2 mM for allantoin (at 40 degrees Celsius and pH 8.0) {ECO 0000269|PubMed 11092864, ECO 0000269|PubMed 12486048}; KM=17.0 mM for allantoin (in zinc-supplemented medium at 37 degrees Celsius and pH 7.4) {ECO 0000269|PubMed 11092864, ECO 0000269|PubMed 12486048}; KM=19.5 mM for allantoin (in cobalt-supplemented medium at 37 degrees Celsius and pH 7.4) {ECO 0000269|PubMed 11092864, ECO 0000269|PubMed 12486048}; KM=80.0 mM for allantoin (in nickel-supplemented medium at 37 degrees Celsius and pH 7.4) {ECO 0000269|PubMed 11092864, ECO 0000269|PubMed 12486048}; Vmax=101 umol/min/mg enzyme (in zinc-supplemented medium at 37 degrees Celsius and pH 7.4) {ECO 0000269|PubMed 11092864, ECO 0000269|PubMed 12486048}; Vmax=8.1 umol/min/mg enzyme (in cobalt-supplemented medium (20mM) at 37 degrees Celsius and pH 7.4) {ECO 0000269|PubMed 11092864, ECO 0000269|PubMed 12486048}; Vmax=6.7 umol/min/mg enzyme (at 40 degrees Celsius and pH 8.0) {ECO 0000269|PubMed 11092864, ECO 0000269|PubMed 12486048}; Vmax=3.9 umol/min/mg enzyme (in cobalt-supplemented medium (2mM) at 37 degrees Celsius and pH 7.4) {ECO 0000269|PubMed 11092864, ECO 0000269|PubMed 12486048}; Vmax=0.7 umol/min/mg enzyme (without added metal at 37 degrees Celsius and pH 7.4) {ECO 0000269|PubMed 11092864, ECO 0000269|PubMed 12486048}; pH dependence Optimum pH is 7.5-8.0. The optimal activity is at pH 8.8 for zinc-containing form and pH 9.0 for cobalt-containing form. {ECO 0000269|PubMed 11092864, ECO 0000269|PubMed 12486048}; Temperature dependence Optimum temperature is 40-45 degrees Celsius. {ECO 0000269|PubMed 11092864, ECO 0000269|PubMed 12486048}; # BRENDA 3.5.2 2026 # BioGrid 4259862 9 # CATALYTIC ACTIVITY (S)-allantoin + H(2)O = allantoate. {ECO:0000269|PubMed 11092864}. # COFACTOR ALLB_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 11092864, ECO 0000269|PubMed 12486048, ECO 0000305}; Name=Ni(2+); Xref=ChEBI CHEBI 49786; Evidence={ECO 0000269|PubMed 11092864, ECO 0000269|PubMed 12486048, ECO 0000305}; Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000269|PubMed 11092864, ECO 0000269|PubMed 12486048, ECO 0000305}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 11092864, ECO 0000269|PubMed 12486048, ECO 0000305}; Note=Binds 2 Zn(2+) ions per subunit. Can also use Ni(2+), Co(2+) or Mn(2+). {ECO 0000269|PubMed 11092864, ECO 0000269|PubMed 12486048, ECO 0000305}; # ENZYME REGULATION ALLB_ECOLI Severely inhibited by copper, and competitively inhibited by dithiothreitol (DTT). Zinc concentrations above 2.5 mM and cobalt or nickel concentrations above 1 mM are inhibitors. {ECO 0000269|PubMed 11092864, ECO 0000269|PubMed 12486048}. # EcoGene EG13619 allB # FUNCTION ALLB_ECOLI Catalyzes the conversion of allantoin (5- ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring. {ECO 0000269|PubMed 10601204, ECO 0000269|PubMed 11092864}. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_function GO:0004038 allantoinase activity; IDA:EcoliWiki. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_function GO:0050897 cobalt ion binding; IEA:InterPro. # GO_process GO:0006145 purine nucleobase catabolic process; IBA:GO_Central. # GO_process GO:0009442 allantoin assimilation pathway; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 2.30.40.10 -; 1. # HAMAP MF_01645 Hydantoinase # INDUCTION ALLB_ECOLI By glyoxylate. # IntAct P77671 7 # InterPro IPR006680 Amidohydro-rel # InterPro IPR011059 Metal-dep_hydrolase_composite # InterPro IPR017593 Allantoinase # InterPro IPR032466 Metal_Hydrolase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # MISCELLANEOUS ALLB_ECOLI The zinc-containing form utilizes only the (S)- isomer of allantoin, whereas the cobalt-containing form prefers the (S)-isomer, but also hydrolyzes the (R)-isomer at about 1/10 the rate. # Organism ALLB_ECOLI Escherichia coli (strain K12) # PATHWAY Nitrogen metabolism; (S)-allantoin degradation; allantoate from (S)-allantoin step 1/1. # PATRIC 32116181 VBIEscCol129921_0532 # PDB 3E74 X-ray; 2.10 A; A/B/C/D=1-453 # PIR G64782 G64782 # PTM ALLB_ECOLI Carbamylation allows a single lysine to coordinate two zinc ions. {ECO 0000250}. # Pfam PF01979 Amidohydro_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ALLB_ECOLI Allantoinase # RefSeq NP_415045 NC_000913.3 # RefSeq WP_000006900 NZ_LN832404.1 # SIMILARITY Belongs to the DHOase family. Allantoinase subfamily. {ECO 0000305}. # SUBUNIT Homotetramer. {ECO:0000269|PubMed 11092864}. # SUPFAM SSF51338 SSF51338; 2 # SUPFAM SSF51556 SSF51556 # TIGRFAMs TIGR03178 allantoinase # UniPathway UPA00395 UER00653 # eggNOG COG0044 LUCA # eggNOG ENOG4105CD3 Bacteria BLAST swissprot:ALLB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ALLB_ECOLI BioCyc ECOL316407:JW0500-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0500-MONOMER BioCyc EcoCyc:G6281-MONOMER http://biocyc.org/getid?id=EcoCyc:G6281-MONOMER BioCyc MetaCyc:G6281-MONOMER http://biocyc.org/getid?id=MetaCyc:G6281-MONOMER COG COG0044 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0044 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.24.7021-7028.2000 http://dx.doi.org/10.1128/JB.182.24.7021-7028.2000 DOI 10.1128/JB.185.1.126-134.2003 http://dx.doi.org/10.1128/JB.185.1.126-134.2003 EC_number EC:3.5.2.5 http://www.genome.jp/dbget-bin/www_bget?EC:3.5.2.5 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL U89279 http://www.ebi.ac.uk/ena/data/view/U89279 ENZYME 3.5.2.5 http://enzyme.expasy.org/EC/3.5.2.5 EchoBASE EB3384 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3384 EcoGene EG13619 http://www.ecogene.org/geneInfo.php?eg_id=EG13619 EnsemblBacteria AAC73614 http://www.ensemblgenomes.org/id/AAC73614 EnsemblBacteria AAC73614 http://www.ensemblgenomes.org/id/AAC73614 EnsemblBacteria BAE76290 http://www.ensemblgenomes.org/id/BAE76290 EnsemblBacteria BAE76290 http://www.ensemblgenomes.org/id/BAE76290 EnsemblBacteria BAE76290 http://www.ensemblgenomes.org/id/BAE76290 EnsemblBacteria b0512 http://www.ensemblgenomes.org/id/b0512 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004038 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004038 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0050897 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050897 GO_process GO:0006145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006145 GO_process GO:0009442 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009442 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 2.30.40.10 http://www.cathdb.info/version/latest/superfamily/2.30.40.10 GeneID 945134 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945134 HAMAP MF_01645 http://hamap.expasy.org/unirule/MF_01645 HOGENOM HOG000219146 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219146&db=HOGENOM6 InParanoid P77671 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77671 IntAct P77671 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77671* IntEnz 3.5.2.5 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.2.5 InterPro IPR006680 http://www.ebi.ac.uk/interpro/entry/IPR006680 InterPro IPR011059 http://www.ebi.ac.uk/interpro/entry/IPR011059 InterPro IPR017593 http://www.ebi.ac.uk/interpro/entry/IPR017593 InterPro IPR032466 http://www.ebi.ac.uk/interpro/entry/IPR032466 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0500 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0500 KEGG_Gene eco:b0512 http://www.genome.jp/dbget-bin/www_bget?eco:b0512 KEGG_Orthology KO:K01466 http://www.genome.jp/dbget-bin/www_bget?KO:K01466 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Reaction rn:R02425 http://www.genome.jp/dbget-bin/www_bget?rn:R02425 OMA EMIPPIT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EMIPPIT PDB 3E74 http://www.ebi.ac.uk/pdbe-srv/view/entry/3E74 PDBsum 3E74 http://www.ebi.ac.uk/pdbsum/3E74 PSORT swissprot:ALLB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ALLB_ECOLI PSORT-B swissprot:ALLB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ALLB_ECOLI PSORT2 swissprot:ALLB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ALLB_ECOLI Pfam PF01979 http://pfam.xfam.org/family/PF01979 Phobius swissprot:ALLB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ALLB_ECOLI PhylomeDB P77671 http://phylomedb.org/?seqid=P77671 ProteinModelPortal P77671 http://www.proteinmodelportal.org/query/uniprot/P77671 PubMed 10601204 http://www.ncbi.nlm.nih.gov/pubmed/10601204 PubMed 11092864 http://www.ncbi.nlm.nih.gov/pubmed/11092864 PubMed 12486048 http://www.ncbi.nlm.nih.gov/pubmed/12486048 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415045 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415045 RefSeq WP_000006900 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000006900 SMR P77671 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77671 STRING 511145.b0512 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0512&targetmode=cogs STRING COG0044 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0044&targetmode=cogs SUPFAM SSF51338 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51338 SUPFAM SSF51556 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51556 TIGRFAMs TIGR03178 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03178 UniProtKB ALLB_ECOLI http://www.uniprot.org/uniprot/ALLB_ECOLI UniProtKB-AC P77671 http://www.uniprot.org/uniprot/P77671 charge swissprot:ALLB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ALLB_ECOLI eggNOG COG0044 http://eggnogapi.embl.de/nog_data/html/tree/COG0044 eggNOG ENOG4105CD3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CD3 epestfind swissprot:ALLB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ALLB_ECOLI garnier swissprot:ALLB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ALLB_ECOLI helixturnhelix swissprot:ALLB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ALLB_ECOLI hmoment swissprot:ALLB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ALLB_ECOLI iep swissprot:ALLB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ALLB_ECOLI inforesidue swissprot:ALLB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ALLB_ECOLI octanol swissprot:ALLB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ALLB_ECOLI pepcoil swissprot:ALLB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ALLB_ECOLI pepdigest swissprot:ALLB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ALLB_ECOLI pepinfo swissprot:ALLB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ALLB_ECOLI pepnet swissprot:ALLB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ALLB_ECOLI pepstats swissprot:ALLB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ALLB_ECOLI pepwheel swissprot:ALLB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ALLB_ECOLI pepwindow swissprot:ALLB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ALLB_ECOLI sigcleave swissprot:ALLB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ALLB_ECOLI ## Database ID URL or Descriptions # BioGrid 4261602 103 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG14419 ybfQ # InterPro IPR032806 YbfD_N # Organism YBFQ_ECOLI Escherichia coli (strain K12) # PATRIC 48660641 VBIEscCol107702_0703 # PIR T48916 T48916 # Pfam PF13808 DDE_Tnp_1_assoc # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBFQ_ECOLI Putative defective transposase YbfQ # RefSeq WP_000421001 NZ_LN832404.1 # eggNOG COG5433 LUCA # eggNOG ENOG410600T Bacteria BLAST swissprot:YBFQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBFQ_ECOLI BioCyc ECOL316407:JW0694-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0694-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14419 http://www.ecogene.org/geneInfo.php?eg_id=EG14419 EnsemblBacteria BAA35363 http://www.ensemblgenomes.org/id/BAA35363 EnsemblBacteria BAA35363 http://www.ensemblgenomes.org/id/BAA35363 EnsemblBacteria BAA35363 http://www.ensemblgenomes.org/id/BAA35363 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv InterPro IPR032806 http://www.ebi.ac.uk/interpro/entry/IPR032806 KEGG_Gene ecj:JW0694 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0694 OMA QAWKVEN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QAWKVEN PSORT swissprot:YBFQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBFQ_ECOLI PSORT-B swissprot:YBFQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBFQ_ECOLI PSORT2 swissprot:YBFQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBFQ_ECOLI Pfam PF13808 http://pfam.xfam.org/family/PF13808 Phobius swissprot:YBFQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBFQ_ECOLI ProteinModelPortal Q2EEQ8 http://www.proteinmodelportal.org/query/uniprot/Q2EEQ8 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000421001 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000421001 STRING 511145.b0706 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0706&targetmode=cogs UniProtKB YBFQ_ECOLI http://www.uniprot.org/uniprot/YBFQ_ECOLI UniProtKB-AC Q2EEQ8 http://www.uniprot.org/uniprot/Q2EEQ8 charge swissprot:YBFQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBFQ_ECOLI eggNOG COG5433 http://eggnogapi.embl.de/nog_data/html/tree/COG5433 eggNOG ENOG410600T http://eggnogapi.embl.de/nog_data/html/tree/ENOG410600T epestfind swissprot:YBFQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBFQ_ECOLI garnier swissprot:YBFQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBFQ_ECOLI helixturnhelix swissprot:YBFQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBFQ_ECOLI hmoment swissprot:YBFQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBFQ_ECOLI iep swissprot:YBFQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBFQ_ECOLI inforesidue swissprot:YBFQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBFQ_ECOLI octanol swissprot:YBFQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBFQ_ECOLI pepcoil swissprot:YBFQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBFQ_ECOLI pepdigest swissprot:YBFQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBFQ_ECOLI pepinfo swissprot:YBFQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBFQ_ECOLI pepnet swissprot:YBFQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBFQ_ECOLI pepstats swissprot:YBFQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBFQ_ECOLI pepwheel swissprot:YBFQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBFQ_ECOLI pepwindow swissprot:YBFQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBFQ_ECOLI sigcleave swissprot:YBFQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBFQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4262291 18 # EcoGene EG13123 ygcP # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:InterPro. # GO_process GO:0009607 response to biotic stimulus; IEA:InterPro. # GOslim_process GO:0008150 biological_process # Gene3D 3.20.20.400 -; 1. # INTERACTION YGCP_ECOLI P0A6Y8 dnaK; NbExp=2; IntAct=EBI-557727, EBI-542092; # IntAct Q46906 11 # InterPro IPR006699 G3P_antiterm # Organism YGCP_ECOLI Escherichia coli (strain K12) # PATRIC 32120948 VBIEscCol129921_2866 # PIR D65058 D65058 # PIRSF PIRSF016897 GlpP # Pfam PF04309 G3P_antiterm # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGCP_ECOLI Uncharacterized protein YgcP # RefSeq NP_417248 NC_000913.3 # RefSeq WP_001130266 NZ_LN832404.1 # SIMILARITY To B.subtilis GlpP. {ECO 0000305}. # SUPFAM SSF110391 SSF110391 # eggNOG COG1954 LUCA # eggNOG ENOG4108ZIA Bacteria BLAST swissprot:YGCP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGCP_ECOLI BioCyc ECOL316407:JW2738-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2738-MONOMER BioCyc EcoCyc:G7434-MONOMER http://biocyc.org/getid?id=EcoCyc:G7434-MONOMER DIP DIP-12132N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12132N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EchoBASE EB2924 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2924 EcoGene EG13123 http://www.ecogene.org/geneInfo.php?eg_id=EG13123 EnsemblBacteria AAC75810 http://www.ensemblgenomes.org/id/AAC75810 EnsemblBacteria AAC75810 http://www.ensemblgenomes.org/id/AAC75810 EnsemblBacteria BAE76845 http://www.ensemblgenomes.org/id/BAE76845 EnsemblBacteria BAE76845 http://www.ensemblgenomes.org/id/BAE76845 EnsemblBacteria BAE76845 http://www.ensemblgenomes.org/id/BAE76845 EnsemblBacteria b2768 http://www.ensemblgenomes.org/id/b2768 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0009607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009607 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.20.20.400 http://www.cathdb.info/version/latest/superfamily/3.20.20.400 GeneID 947536 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947536 HOGENOM HOG000011232 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000011232&db=HOGENOM6 InParanoid Q46906 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46906 IntAct Q46906 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46906* InterPro IPR006699 http://www.ebi.ac.uk/interpro/entry/IPR006699 KEGG_Gene ecj:JW2738 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2738 KEGG_Gene eco:b2768 http://www.genome.jp/dbget-bin/www_bget?eco:b2768 MINT MINT-1221014 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1221014 OMA GIKHDEY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GIKHDEY PSORT swissprot:YGCP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGCP_ECOLI PSORT-B swissprot:YGCP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGCP_ECOLI PSORT2 swissprot:YGCP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGCP_ECOLI Pfam PF04309 http://pfam.xfam.org/family/PF04309 Phobius swissprot:YGCP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGCP_ECOLI PhylomeDB Q46906 http://phylomedb.org/?seqid=Q46906 ProteinModelPortal Q46906 http://www.proteinmodelportal.org/query/uniprot/Q46906 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417248 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417248 RefSeq WP_001130266 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001130266 SMR Q46906 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46906 STRING 511145.b2768 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2768&targetmode=cogs SUPFAM SSF110391 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF110391 UniProtKB YGCP_ECOLI http://www.uniprot.org/uniprot/YGCP_ECOLI UniProtKB-AC Q46906 http://www.uniprot.org/uniprot/Q46906 charge swissprot:YGCP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGCP_ECOLI eggNOG COG1954 http://eggnogapi.embl.de/nog_data/html/tree/COG1954 eggNOG ENOG4108ZIA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZIA epestfind swissprot:YGCP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGCP_ECOLI garnier swissprot:YGCP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGCP_ECOLI helixturnhelix swissprot:YGCP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGCP_ECOLI hmoment swissprot:YGCP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGCP_ECOLI iep swissprot:YGCP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGCP_ECOLI inforesidue swissprot:YGCP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGCP_ECOLI octanol swissprot:YGCP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGCP_ECOLI pepcoil swissprot:YGCP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGCP_ECOLI pepdigest swissprot:YGCP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGCP_ECOLI pepinfo swissprot:YGCP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGCP_ECOLI pepnet swissprot:YGCP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGCP_ECOLI pepstats swissprot:YGCP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGCP_ECOLI pepwheel swissprot:YGCP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGCP_ECOLI pepwindow swissprot:YGCP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGCP_ECOLI sigcleave swissprot:YGCP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGCP_ECOLI ## Database ID URL or Descriptions # BioGrid 4261961 15 # CATALYTIC ACTIVITY Cyclic di-3',5'-guanylate + H(2)O = 5'- phosphoguanylyl(3'->5')guanosine. {ECO:0000269|PubMed 17010156}. # CDD cd01948 EAL # CDD cd01949 GGDEF # DISRUPTION PHENOTYPE Leads to overproduction of curli fimbrae and autoaggregation in cultures grown at 28 degrees Celsius. {ECO:0000269|PubMed 17010156}. # EcoGene EG13415 gmr # FUNCTION GMR_ECOLI Part of a 2 protein system that seems to be dedicated to transcription of csgD. This protein decreases csgD transcription and thus decreases expression of adhesive curli fimbriae genes csgEFG, csgBAC/ymaD and adrA (yaic). Activity of this protein is antagonized by the diguanylate cyclase YdaM. In vitro has c-di-GMP phosphodiesterase activity. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria. {ECO 0000269|PubMed 17010156}. # GO_function GO:0005525 GTP binding; IDA:EcoCyc. # GO_function GO:0071111 cyclic-guanylate-specific phosphodiesterase activity; IDA:EcoCyc. # GO_process GO:0010608 posttranscriptional regulation of gene expression; IMP:EcoCyc. # GO_process GO:0031280 negative regulation of cyclase activity; IDA:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # Gene3D 3.20.20.450 -; 1. # INDUCTION GMR_ECOLI Constitutively expressed at both 28 and 37 degrees Celsius, during transition into stationary phase, more highly expressed on plates than in liquid medium. Expression is RpoS dependent and repressed by H-NS. {ECO 0000269|PubMed 17010156, ECO 0000269|PubMed 19332833}. # INTERACTION GMR_ECOLI P33358 mlrA; NbExp=2; IntAct=EBI-548149, EBI-1127668; P77302 ydaM; NbExp=5; IntAct=EBI-548149, EBI-544662; # IntAct P77334 6 # InterPro IPR000014 PAS # InterPro IPR000160 GGDEF_dom # InterPro IPR001633 EAL_dom # InterPro IPR029787 Nucleotide_cyclase # KEGG_Brite ko01000 Enzymes # Organism GMR_ECOLI Escherichia coli (strain K12) # PATRIC 32117836 VBIEscCol129921_1338 # PIR H64876 H64876 # PROSITE PS50112 PAS # PROSITE PS50883 EAL # PROSITE PS50887 GGDEF # Pfam PF00563 EAL # Pfam PF00990 GGDEF # Pfam PF13426 PAS_9 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GMR_ECOLI Cyclic di-GMP phosphodiesterase Gmr # RefSeq NP_415801 NC_000913.3 # RefSeq WP_000859945 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=L40788; Type=Frameshift; Positions=5, 25, 365, 392, 451; Evidence={ECO 0000305}; # SIMILARITY Contains 1 EAL domain. {ECO:0000255|PROSITE- ProRule PRU00074}. # SIMILARITY Contains 1 GGDEF domain. {ECO:0000255|PROSITE- ProRule PRU00095}. # SIMILARITY Contains 1 PAS (PER-ARNT-SIM) domain. {ECO:0000255|PROSITE-ProRule PRU00140}. # SMART SM00052 EAL # SMART SM00091 PAS # SMART SM00267 GGDEF # SUPFAM SSF141868 SSF141868 # SUPFAM SSF55073 SSF55073 # SUPFAM SSF55785 SSF55785 # TIGRFAMs TIGR00229 sensory_box # TIGRFAMs TIGR00254 GGDEF # eggNOG COG2199 LUCA # eggNOG COG2200 LUCA # eggNOG COG2202 LUCA # eggNOG ENOG4105BZU Bacteria BLAST swissprot:GMR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GMR_ECOLI BioCyc ECOL316407:JW1278-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1278-MONOMER BioCyc EcoCyc:G6639-MONOMER http://biocyc.org/getid?id=EcoCyc:G6639-MONOMER BioCyc MetaCyc:G6639-MONOMER http://biocyc.org/getid?id=MetaCyc:G6639-MONOMER COG COG2199 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2199 COG COG2200 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2200 COG COG2202 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2202 DIP DIP-11590N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11590N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1099/mic.0.024257-0 http://dx.doi.org/10.1099/mic.0.024257-0 DOI 10.1111/j.1365-2958.2006.05440.x http://dx.doi.org/10.1111/j.1365-2958.2006.05440.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.4.52 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.4.52 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L40788 http://www.ebi.ac.uk/ena/data/view/L40788 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.4.52 http://enzyme.expasy.org/EC/3.1.4.52 EchoBASE EB3191 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3191 EcoGene EG13415 http://www.ecogene.org/geneInfo.php?eg_id=EG13415 EnsemblBacteria AAC74367 http://www.ensemblgenomes.org/id/AAC74367 EnsemblBacteria AAC74367 http://www.ensemblgenomes.org/id/AAC74367 EnsemblBacteria BAA14839 http://www.ensemblgenomes.org/id/BAA14839 EnsemblBacteria BAA14839 http://www.ensemblgenomes.org/id/BAA14839 EnsemblBacteria BAA14839 http://www.ensemblgenomes.org/id/BAA14839 EnsemblBacteria b1285 http://www.ensemblgenomes.org/id/b1285 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_function GO:0071111 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071111 GO_process GO:0010608 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010608 GO_process GO:0031280 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031280 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.20.20.450 http://www.cathdb.info/version/latest/superfamily/3.20.20.450 GeneID 945868 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945868 HOGENOM HOG000136248 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000136248&db=HOGENOM6 InParanoid P77334 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77334 IntAct P77334 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77334* IntEnz 3.1.4.52 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.4.52 InterPro IPR000014 http://www.ebi.ac.uk/interpro/entry/IPR000014 InterPro IPR000160 http://www.ebi.ac.uk/interpro/entry/IPR000160 InterPro IPR001633 http://www.ebi.ac.uk/interpro/entry/IPR001633 InterPro IPR029787 http://www.ebi.ac.uk/interpro/entry/IPR029787 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1278 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1278 KEGG_Gene eco:b1285 http://www.genome.jp/dbget-bin/www_bget?eco:b1285 KEGG_Orthology KO:K14051 http://www.genome.jp/dbget-bin/www_bget?KO:K14051 MINT MINT-1265402 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1265402 OMA YTGLKEQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YTGLKEQ PROSITE PS50112 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50112 PROSITE PS50883 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50883 PROSITE PS50887 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50887 PSORT swissprot:GMR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GMR_ECOLI PSORT-B swissprot:GMR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GMR_ECOLI PSORT2 swissprot:GMR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GMR_ECOLI Pfam PF00563 http://pfam.xfam.org/family/PF00563 Pfam PF00990 http://pfam.xfam.org/family/PF00990 Pfam PF13426 http://pfam.xfam.org/family/PF13426 Phobius swissprot:GMR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GMR_ECOLI PhylomeDB P77334 http://phylomedb.org/?seqid=P77334 ProteinModelPortal P77334 http://www.proteinmodelportal.org/query/uniprot/P77334 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17010156 http://www.ncbi.nlm.nih.gov/pubmed/17010156 PubMed 19332833 http://www.ncbi.nlm.nih.gov/pubmed/19332833 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415801 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415801 RefSeq WP_000859945 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000859945 SMART SM00052 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00052 SMART SM00091 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00091 SMART SM00267 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00267 SMR P77334 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77334 STRING 511145.b1285 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1285&targetmode=cogs STRING COG2199 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2199&targetmode=cogs STRING COG2200 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2200&targetmode=cogs STRING COG2202 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2202&targetmode=cogs SUPFAM SSF141868 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF141868 SUPFAM SSF55073 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55073 SUPFAM SSF55785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55785 TIGRFAMs TIGR00229 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00229 TIGRFAMs TIGR00254 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00254 UniProtKB GMR_ECOLI http://www.uniprot.org/uniprot/GMR_ECOLI UniProtKB-AC P77334 http://www.uniprot.org/uniprot/P77334 charge swissprot:GMR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GMR_ECOLI eggNOG COG2199 http://eggnogapi.embl.de/nog_data/html/tree/COG2199 eggNOG COG2200 http://eggnogapi.embl.de/nog_data/html/tree/COG2200 eggNOG COG2202 http://eggnogapi.embl.de/nog_data/html/tree/COG2202 eggNOG ENOG4105BZU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZU epestfind swissprot:GMR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GMR_ECOLI garnier swissprot:GMR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GMR_ECOLI helixturnhelix swissprot:GMR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GMR_ECOLI hmoment swissprot:GMR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GMR_ECOLI iep swissprot:GMR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GMR_ECOLI inforesidue swissprot:GMR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GMR_ECOLI octanol swissprot:GMR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GMR_ECOLI pepcoil swissprot:GMR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GMR_ECOLI pepdigest swissprot:GMR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GMR_ECOLI pepinfo swissprot:GMR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GMR_ECOLI pepnet swissprot:GMR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GMR_ECOLI pepstats swissprot:GMR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GMR_ECOLI pepwheel swissprot:GMR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GMR_ECOLI pepwindow swissprot:GMR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GMR_ECOLI sigcleave swissprot:GMR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GMR_ECOLI ## Database ID URL or Descriptions # BioGrid 4262054 11 # EcoGene EG11139 yecA # Gene3D 3.10.450.50 -; 1. # IntAct P0AD05 21 # InterPro IPR004027 SEC_C_motif # InterPro IPR011978 UPF0149 # InterPro IPR032710 NTF2-like_dom # Organism YECA_ECOLI Escherichia coli (strain K12) # PATRIC 32119147 VBIEscCol129921_1991 # PIR D64954 QQECW7 # Pfam PF02810 SEC-C # Pfam PF03695 UPF0149 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YECA_ECOLI Uncharacterized protein YecA # RefSeq NP_416421 NC_000913.3 # RefSeq WP_000847902 NZ_LN832404.1 # SUPFAM SSF101327 SSF101327 # TIGRFAMs TIGR02292 ygfB_yecA # eggNOG COG3318 LUCA # eggNOG ENOG4106RHG Bacteria BLAST swissprot:YECA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YECA_ECOLI BioCyc ECOL316407:JW1896-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1896-MONOMER BioCyc EcoCyc:EG11139-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11139-MONOMER COG COG3318 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3318 DIP DIP-48035N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48035N DOI 10.1016/S0300-9084(85)80300-X http://dx.doi.org/10.1016/S0300-9084(85)80300-X DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X03239 http://www.ebi.ac.uk/ena/data/view/X03239 EchoBASE EB1129 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1129 EcoGene EG11139 http://www.ecogene.org/geneInfo.php?eg_id=EG11139 EnsemblBacteria AAC74978 http://www.ensemblgenomes.org/id/AAC74978 EnsemblBacteria AAC74978 http://www.ensemblgenomes.org/id/AAC74978 EnsemblBacteria BAA15731 http://www.ensemblgenomes.org/id/BAA15731 EnsemblBacteria BAA15731 http://www.ensemblgenomes.org/id/BAA15731 EnsemblBacteria BAA15731 http://www.ensemblgenomes.org/id/BAA15731 EnsemblBacteria b1908 http://www.ensemblgenomes.org/id/b1908 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.10.450.50 http://www.cathdb.info/version/latest/superfamily/3.10.450.50 GeneID 945061 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945061 HOGENOM HOG000121287 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000121287&db=HOGENOM6 InParanoid P0AD05 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AD05 IntAct P0AD05 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AD05* InterPro IPR004027 http://www.ebi.ac.uk/interpro/entry/IPR004027 InterPro IPR011978 http://www.ebi.ac.uk/interpro/entry/IPR011978 InterPro IPR032710 http://www.ebi.ac.uk/interpro/entry/IPR032710 KEGG_Gene ecj:JW1896 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1896 KEGG_Gene eco:b1908 http://www.genome.jp/dbget-bin/www_bget?eco:b1908 KEGG_Orthology KO:K07039 http://www.genome.jp/dbget-bin/www_bget?KO:K07039 OMA CFGYLRG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CFGYLRG PSORT swissprot:YECA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YECA_ECOLI PSORT-B swissprot:YECA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YECA_ECOLI PSORT2 swissprot:YECA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YECA_ECOLI Pfam PF02810 http://pfam.xfam.org/family/PF02810 Pfam PF03695 http://pfam.xfam.org/family/PF03695 Phobius swissprot:YECA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YECA_ECOLI ProteinModelPortal P0AD05 http://www.proteinmodelportal.org/query/uniprot/P0AD05 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3002500 http://www.ncbi.nlm.nih.gov/pubmed/3002500 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416421 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416421 RefSeq WP_000847902 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000847902 STRING 511145.b1908 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1908&targetmode=cogs STRING COG3318 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3318&targetmode=cogs SUPFAM SSF101327 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF101327 TIGRFAMs TIGR02292 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02292 UniProtKB YECA_ECOLI http://www.uniprot.org/uniprot/YECA_ECOLI UniProtKB-AC P0AD05 http://www.uniprot.org/uniprot/P0AD05 charge swissprot:YECA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YECA_ECOLI eggNOG COG3318 http://eggnogapi.embl.de/nog_data/html/tree/COG3318 eggNOG ENOG4106RHG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106RHG epestfind swissprot:YECA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YECA_ECOLI garnier swissprot:YECA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YECA_ECOLI helixturnhelix swissprot:YECA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YECA_ECOLI hmoment swissprot:YECA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YECA_ECOLI iep swissprot:YECA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YECA_ECOLI inforesidue swissprot:YECA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YECA_ECOLI octanol swissprot:YECA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YECA_ECOLI pepcoil swissprot:YECA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YECA_ECOLI pepdigest swissprot:YECA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YECA_ECOLI pepinfo swissprot:YECA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YECA_ECOLI pepnet swissprot:YECA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YECA_ECOLI pepstats swissprot:YECA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YECA_ECOLI pepwheel swissprot:YECA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YECA_ECOLI pepwindow swissprot:YECA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YECA_ECOLI sigcleave swissprot:YECA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YECA_ECOLI ## Database ID URL or Descriptions # AltName FIS_ECOLI Factor-for-inversion stimulation protein # AltName FIS_ECOLI Hin recombinational enhancer-binding protein # BioGrid 4261864 53 # EcoGene EG10317 fis # FUNCTION FIS_ECOLI Activates ribosomal RNA transcription, as well other genes. Plays a direct role in upstream activation of rRNA promoters. Binds to a recombinational enhancer sequence that is required to stimulate hin-mediated DNA inversion. Prevents initiation of DNA replication from oriC. Binds to hundreds of transcriptionally active and inactive AT-rich sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome (PubMed 16963779). {ECO 0000269|PubMed 16963779, ECO 0000269|PubMed 2209559, ECO 0000269|PubMed 8836178}. # GO_component GO:0000787 cytoplasmic nucleosome; IDA:EcoCyc. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0009295 nucleoid; IEA:UniProtKB-SubCell. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0043565 sequence-specific DNA binding; IDA:EcoliWiki. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.60 -; 1. # HAMAP MF_00166 DNA_binding_Fis # INTERACTION FIS_ECOLI P64503 yebV; NbExp=3; IntAct=EBI-550170, EBI-9126792; # IntAct P0A6R3 25 # InterPro IPR002197 HTH_Fis # InterPro IPR005412 Fis_DNA-bd # InterPro IPR009057 Homeodomain-like # KEGG_Brite ko03000 Transcription factors # KEGG_Brite ko03036 Chromosome # KEGG_Brite ko03400 DNA repair and recombination proteins # Organism FIS_ECOLI Escherichia coli (strain K12) # PATRIC 32121952 VBIEscCol129921_3360 # PDB 1ETK X-ray; 2.10 A; A/B=1-98 # PDB 1ETO X-ray; 1.90 A; A/B=1-98 # PDB 1ETQ X-ray; 2.80 A; A/B/C/D=1-98 # PDB 1ETV X-ray; 2.00 A; A/B=1-98 # PDB 1ETW X-ray; 2.00 A; A/B=1-98 # PDB 1ETX X-ray; 1.90 A; A/B=1-98 # PDB 1ETY X-ray; 2.00 A; A/B=1-98 # PDB 1F36 X-ray; 2.65 A; A/B=1-98 # PDB 1FIA X-ray; 2.00 A; A/B=1-98 # PDB 1FIP X-ray; 1.90 A; A/B=1-98 # PDB 3FIS X-ray; 2.30 A; A/B=1-98 # PDB 3IV5 X-ray; 2.90 A; A/B=1-98 # PDB 3JR9 X-ray; 2.90 A; A/B=1-98 # PDB 3JRA X-ray; 3.11 A; A/B=1-98 # PDB 3JRB X-ray; 3.10 A; A/B=1-98 # PDB 3JRC X-ray; 3.08 A; A/B=1-98 # PDB 3JRD X-ray; 3.10 A; A/B=1-98 # PDB 3JRE X-ray; 3.17 A; A/B=1-98 # PDB 3JRF X-ray; 3.05 A; A/B=1-98 # PDB 3JRG X-ray; 3.11 A; A/B=1-98 # PDB 3JRH X-ray; 2.88 A; A/B=1-98 # PDB 3JRI X-ray; 3.11 A; A/B=1-98 # PDB 4FIS X-ray; 2.30 A; A/B=1-98 # PDB 5DS9 X-ray; 2.56 A; A/B=1-98 # PDB 5DTD X-ray; 2.64 A; A/B=1-98 # PDB 5E3L X-ray; 2.66 A; A/B=1-98 # PDB 5E3M X-ray; 2.89 A; A/B=1-98 # PDB 5E3N X-ray; 2.66 A; A/B=1-98 # PDB 5E3O X-ray; 2.78 A; A/B=1-98 # PIR A32142 DNECFS # PIRSF PIRSF002097 DNA-binding_Fis # PRINTS PR01590 HTHFIS # PRINTS PR01591 DNABINDNGFIS # Pfam PF02954 HTH_8 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DNA-binding protein Fis {ECO:0000255|HAMAP-Rule MF_00166} # RefSeq NP_417727 NC_000913.3 # RefSeq WP_000462905 NZ_LN832404.1 # SIMILARITY Belongs to the transcriptional regulatory Fis family. {ECO:0000255|HAMAP-Rule MF_00166}. # SUBCELLULAR LOCATION FIS_ECOLI Cytoplasm, nucleoid {ECO 0000269|PubMed 21903814}. Note=Scattered throughout the nucleoid (PubMed 21903814). {ECO 0000269|PubMed 21903814}. # SUBUNIT FIS_ECOLI Homodimer. # SUPFAM SSF46689 SSF46689 # eggNOG COG2901 LUCA BLAST swissprot:FIS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FIS_ECOLI BioCyc ECOL316407:JW3229-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3229-MONOMER BioCyc EcoCyc:PD00196 http://biocyc.org/getid?id=EcoCyc:PD00196 COG COG2901 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2901 DIP DIP-47975N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47975N DOI 10.1006/jmbi.2000.4123 http://dx.doi.org/10.1006/jmbi.2000.4123 DOI 10.1016/0022-2836(92)90134-6 http://dx.doi.org/10.1016/0022-2836(92)90134-6 DOI 10.1038/349178a0 http://dx.doi.org/10.1038/349178a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.85.10.3484 http://dx.doi.org/10.1073/pnas.85.10.3484 DOI 10.1073/pnas.85.12.4237 http://dx.doi.org/10.1073/pnas.85.12.4237 DOI 10.1074/jbc.M008832200 http://dx.doi.org/10.1074/jbc.M008832200 DOI 10.1093/emboj/16.22.6860 http://dx.doi.org/10.1093/emboj/16.22.6860 DOI 10.1093/nar/24.18.3527 http://dx.doi.org/10.1093/nar/24.18.3527 DOI 10.1093/nar/gkl542 http://dx.doi.org/10.1093/nar/gkl542 DOI 10.1111/j.1365-2958.1996.tb02545.x http://dx.doi.org/10.1111/j.1365-2958.1996.tb02545.x DOI 10.1126/science.1204697 http://dx.doi.org/10.1126/science.1204697 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DisProt DP00422 http://www.disprot.org/protein.php?id=DP00422 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J03245 http://www.ebi.ac.uk/ena/data/view/J03245 EMBL J03816 http://www.ebi.ac.uk/ena/data/view/J03816 EMBL M95784 http://www.ebi.ac.uk/ena/data/view/M95784 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB0313 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0313 EcoGene EG10317 http://www.ecogene.org/geneInfo.php?eg_id=EG10317 EnsemblBacteria AAC76293 http://www.ensemblgenomes.org/id/AAC76293 EnsemblBacteria AAC76293 http://www.ensemblgenomes.org/id/AAC76293 EnsemblBacteria BAE77302 http://www.ensemblgenomes.org/id/BAE77302 EnsemblBacteria BAE77302 http://www.ensemblgenomes.org/id/BAE77302 EnsemblBacteria BAE77302 http://www.ensemblgenomes.org/id/BAE77302 EnsemblBacteria b3261 http://www.ensemblgenomes.org/id/b3261 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0000787 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000787 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0009295 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009295 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 GeneID 8911232 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8911232 GeneID 947697 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947697 HAMAP MF_00166 http://hamap.expasy.org/unirule/MF_00166 HOGENOM HOG000256331 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000256331&db=HOGENOM6 InParanoid P0A6R3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6R3 IntAct P0A6R3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6R3* InterPro IPR002197 http://www.ebi.ac.uk/interpro/entry/IPR002197 InterPro IPR005412 http://www.ebi.ac.uk/interpro/entry/IPR005412 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW3229 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3229 KEGG_Gene eco:b3261 http://www.genome.jp/dbget-bin/www_bget?eco:b3261 KEGG_Orthology KO:K03557 http://www.genome.jp/dbget-bin/www_bget?KO:K03557 MINT MINT-1225073 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1225073 OMA MSDNANL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MSDNANL PDB 1ETK http://www.ebi.ac.uk/pdbe-srv/view/entry/1ETK PDB 1ETO http://www.ebi.ac.uk/pdbe-srv/view/entry/1ETO PDB 1ETQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1ETQ PDB 1ETV http://www.ebi.ac.uk/pdbe-srv/view/entry/1ETV PDB 1ETW http://www.ebi.ac.uk/pdbe-srv/view/entry/1ETW PDB 1ETX http://www.ebi.ac.uk/pdbe-srv/view/entry/1ETX PDB 1ETY http://www.ebi.ac.uk/pdbe-srv/view/entry/1ETY PDB 1F36 http://www.ebi.ac.uk/pdbe-srv/view/entry/1F36 PDB 1FIA http://www.ebi.ac.uk/pdbe-srv/view/entry/1FIA PDB 1FIP http://www.ebi.ac.uk/pdbe-srv/view/entry/1FIP PDB 3FIS http://www.ebi.ac.uk/pdbe-srv/view/entry/3FIS PDB 3IV5 http://www.ebi.ac.uk/pdbe-srv/view/entry/3IV5 PDB 3JR9 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JR9 PDB 3JRA http://www.ebi.ac.uk/pdbe-srv/view/entry/3JRA PDB 3JRB http://www.ebi.ac.uk/pdbe-srv/view/entry/3JRB PDB 3JRC http://www.ebi.ac.uk/pdbe-srv/view/entry/3JRC PDB 3JRD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JRD PDB 3JRE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JRE PDB 3JRF http://www.ebi.ac.uk/pdbe-srv/view/entry/3JRF PDB 3JRG http://www.ebi.ac.uk/pdbe-srv/view/entry/3JRG PDB 3JRH http://www.ebi.ac.uk/pdbe-srv/view/entry/3JRH PDB 3JRI http://www.ebi.ac.uk/pdbe-srv/view/entry/3JRI PDB 4FIS http://www.ebi.ac.uk/pdbe-srv/view/entry/4FIS PDB 5DS9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5DS9 PDB 5DTD http://www.ebi.ac.uk/pdbe-srv/view/entry/5DTD PDB 5E3L http://www.ebi.ac.uk/pdbe-srv/view/entry/5E3L PDB 5E3M http://www.ebi.ac.uk/pdbe-srv/view/entry/5E3M PDB 5E3N http://www.ebi.ac.uk/pdbe-srv/view/entry/5E3N PDB 5E3O http://www.ebi.ac.uk/pdbe-srv/view/entry/5E3O PDBsum 1ETK http://www.ebi.ac.uk/pdbsum/1ETK PDBsum 1ETO http://www.ebi.ac.uk/pdbsum/1ETO PDBsum 1ETQ http://www.ebi.ac.uk/pdbsum/1ETQ PDBsum 1ETV http://www.ebi.ac.uk/pdbsum/1ETV PDBsum 1ETW http://www.ebi.ac.uk/pdbsum/1ETW PDBsum 1ETX http://www.ebi.ac.uk/pdbsum/1ETX PDBsum 1ETY http://www.ebi.ac.uk/pdbsum/1ETY PDBsum 1F36 http://www.ebi.ac.uk/pdbsum/1F36 PDBsum 1FIA http://www.ebi.ac.uk/pdbsum/1FIA PDBsum 1FIP http://www.ebi.ac.uk/pdbsum/1FIP PDBsum 3FIS http://www.ebi.ac.uk/pdbsum/3FIS PDBsum 3IV5 http://www.ebi.ac.uk/pdbsum/3IV5 PDBsum 3JR9 http://www.ebi.ac.uk/pdbsum/3JR9 PDBsum 3JRA http://www.ebi.ac.uk/pdbsum/3JRA PDBsum 3JRB http://www.ebi.ac.uk/pdbsum/3JRB PDBsum 3JRC http://www.ebi.ac.uk/pdbsum/3JRC PDBsum 3JRD http://www.ebi.ac.uk/pdbsum/3JRD PDBsum 3JRE http://www.ebi.ac.uk/pdbsum/3JRE PDBsum 3JRF http://www.ebi.ac.uk/pdbsum/3JRF PDBsum 3JRG http://www.ebi.ac.uk/pdbsum/3JRG PDBsum 3JRH http://www.ebi.ac.uk/pdbsum/3JRH PDBsum 3JRI http://www.ebi.ac.uk/pdbsum/3JRI PDBsum 4FIS http://www.ebi.ac.uk/pdbsum/4FIS PDBsum 5DS9 http://www.ebi.ac.uk/pdbsum/5DS9 PDBsum 5DTD http://www.ebi.ac.uk/pdbsum/5DTD PDBsum 5E3L http://www.ebi.ac.uk/pdbsum/5E3L PDBsum 5E3M http://www.ebi.ac.uk/pdbsum/5E3M PDBsum 5E3N http://www.ebi.ac.uk/pdbsum/5E3N PDBsum 5E3O http://www.ebi.ac.uk/pdbsum/5E3O PRINTS PR01590 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01590 PRINTS PR01591 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01591 PSORT swissprot:FIS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FIS_ECOLI PSORT-B swissprot:FIS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FIS_ECOLI PSORT2 swissprot:FIS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FIS_ECOLI Pfam PF02954 http://pfam.xfam.org/family/PF02954 Phobius swissprot:FIS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FIS_ECOLI PhylomeDB P0A6R3 http://phylomedb.org/?seqid=P0A6R3 ProteinModelPortal P0A6R3 http://www.proteinmodelportal.org/query/uniprot/P0A6R3 PubMed 11071896 http://www.ncbi.nlm.nih.gov/pubmed/11071896 PubMed 11183780 http://www.ncbi.nlm.nih.gov/pubmed/11183780 PubMed 1459953 http://www.ncbi.nlm.nih.gov/pubmed/1459953 PubMed 1619650 http://www.ncbi.nlm.nih.gov/pubmed/1619650 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16963779 http://www.ncbi.nlm.nih.gov/pubmed/16963779 PubMed 1851089 http://www.ncbi.nlm.nih.gov/pubmed/1851089 PubMed 1986310 http://www.ncbi.nlm.nih.gov/pubmed/1986310 PubMed 21903814 http://www.ncbi.nlm.nih.gov/pubmed/21903814 PubMed 2209559 http://www.ncbi.nlm.nih.gov/pubmed/2209559 PubMed 2835774 http://www.ncbi.nlm.nih.gov/pubmed/2835774 PubMed 2837762 http://www.ncbi.nlm.nih.gov/pubmed/2837762 PubMed 8809757 http://www.ncbi.nlm.nih.gov/pubmed/8809757 PubMed 8836178 http://www.ncbi.nlm.nih.gov/pubmed/8836178 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9362499 http://www.ncbi.nlm.nih.gov/pubmed/9362499 RefSeq NP_417727 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417727 RefSeq WP_000462905 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000462905 SMR P0A6R3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6R3 STRING 511145.b3261 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3261&targetmode=cogs STRING COG2901 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2901&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 UniProtKB FIS_ECOLI http://www.uniprot.org/uniprot/FIS_ECOLI UniProtKB-AC P0A6R3 http://www.uniprot.org/uniprot/P0A6R3 charge swissprot:FIS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FIS_ECOLI eggNOG COG2901 http://eggnogapi.embl.de/nog_data/html/tree/COG2901 epestfind swissprot:FIS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FIS_ECOLI garnier swissprot:FIS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FIS_ECOLI helixturnhelix swissprot:FIS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FIS_ECOLI hmoment swissprot:FIS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FIS_ECOLI iep swissprot:FIS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FIS_ECOLI inforesidue swissprot:FIS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FIS_ECOLI octanol swissprot:FIS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FIS_ECOLI pepcoil swissprot:FIS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FIS_ECOLI pepdigest swissprot:FIS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FIS_ECOLI pepinfo swissprot:FIS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FIS_ECOLI pepnet swissprot:FIS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FIS_ECOLI pepstats swissprot:FIS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FIS_ECOLI pepwheel swissprot:FIS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FIS_ECOLI pepwindow swissprot:FIS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FIS_ECOLI sigcleave swissprot:FIS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FIS_ECOLI ## Database ID URL or Descriptions # BRENDA 3.6.3.33 2026 # BioGrid 4261861 275 # EcoGene EG12334 btuF # FUNCTION BTUF_ECOLI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC. {ECO 0000255|HAMAP-Rule MF_01000, ECO 0000269|PubMed 11790740}. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_component GO:0042597 periplasmic space; IDA:EcoliWiki. # GO_function GO:0031419 cobalamin binding; IDA:EcoliWiki. # GO_process GO:0015889 cobalamin transport; IMP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006810 transport # HAMAP MF_01000 BtuF # IntAct P37028 5 # InterPro IPR002491 ABC_transptr_periplasmic_BD # InterPro IPR023544 ABC_transptr_vit_B12-bd # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00241 Vitamin B12 transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # MISCELLANEOUS Vitamin B12 is bound in a deep cleft formed at the interface between the two lobes of BtuF. {ECO:0000269|PubMed 12475936}. # Organism BTUF_ECOLI Escherichia coli (strain K12) # PATRIC 32115425 VBIEscCol129921_0164 # PDB 1N2Z X-ray; 2.00 A; A/B=22-266 # PDB 1N4A X-ray; 2.00 A; A/B=23-266 # PDB 1N4D X-ray; 3.00 A; A/B=23-266 # PDB 2QI9 X-ray; 2.60 A; F=22-266 # PDB 4DBL X-ray; 3.49 A; E/J=22-266 # PDB 4FI3 X-ray; 3.47 A; F=22-266 # PIR F64739 F64739 # PROSITE PS50983 FE_B12_PBP # Pfam PF01497 Peripla_BP_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Vitamin B12-binding protein {ECO:0000255|HAMAP-Rule MF_01000} # RefSeq NP_414700 NC_000913.3 # RefSeq WP_001129927 NZ_LN832404.1 # SIMILARITY Belongs to the BtuF family. {ECO:0000255|HAMAP- Rule MF_01000, ECO:0000305}. # SIMILARITY Contains 1 Fe/B12 periplasmic-binding domain. {ECO:0000255|HAMAP-Rule MF_01000}. # SUBCELLULAR LOCATION BTUF_ECOLI Periplasm {ECO 0000255|HAMAP-Rule MF_01000, ECO 0000269|PubMed 11790740}. # SUBUNIT BTUF_ECOLI The complex is composed of two ATP-binding proteins (BtuD), two transmembrane proteins (BtuC) and a solute-binding protein (BtuF). {ECO 0000255|HAMAP-Rule MF_01000, ECO 0000269|PubMed 12468528, ECO 0000269|PubMed 12475936}. # eggNOG COG0614 LUCA # eggNOG ENOG4105JKQ Bacteria BLAST swissprot:BTUF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BTUF_ECOLI BioCyc ECOL316407:JW0154-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0154-MONOMER BioCyc EcoCyc:EG12334-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12334-MONOMER BioCyc MetaCyc:EG12334-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12334-MONOMER COG COG0614 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0614 DIP DIP-11194N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11194N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.262659699 http://dx.doi.org/10.1073/pnas.262659699 DOI 10.1074/jbc.M212239200 http://dx.doi.org/10.1074/jbc.M212239200 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.3.706-717.2002 http://dx.doi.org/10.1128/JB.184.3.706-717.2002 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EchoBASE EB2238 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2238 EcoGene EG12334 http://www.ecogene.org/geneInfo.php?eg_id=EG12334 EnsemblBacteria AAC73269 http://www.ensemblgenomes.org/id/AAC73269 EnsemblBacteria AAC73269 http://www.ensemblgenomes.org/id/AAC73269 EnsemblBacteria BAB96735 http://www.ensemblgenomes.org/id/BAB96735 EnsemblBacteria BAB96735 http://www.ensemblgenomes.org/id/BAB96735 EnsemblBacteria BAB96735 http://www.ensemblgenomes.org/id/BAB96735 EnsemblBacteria b0158 http://www.ensemblgenomes.org/id/b0158 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0031419 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031419 GO_process GO:0015889 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015889 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 947574 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947574 HAMAP MF_01000 http://hamap.expasy.org/unirule/MF_01000 HOGENOM HOG000282913 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000282913&db=HOGENOM6 InParanoid P37028 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37028 IntAct P37028 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37028* InterPro IPR002491 http://www.ebi.ac.uk/interpro/entry/IPR002491 InterPro IPR023544 http://www.ebi.ac.uk/interpro/entry/IPR023544 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0154 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0154 KEGG_Gene eco:b0158 http://www.genome.jp/dbget-bin/www_bget?eco:b0158 KEGG_Orthology KO:K06858 http://www.genome.jp/dbget-bin/www_bget?KO:K06858 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 MINT MINT-6803779 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-6803779 OMA VSVFYQV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VSVFYQV PDB 1N2Z http://www.ebi.ac.uk/pdbe-srv/view/entry/1N2Z PDB 1N4A http://www.ebi.ac.uk/pdbe-srv/view/entry/1N4A PDB 1N4D http://www.ebi.ac.uk/pdbe-srv/view/entry/1N4D PDB 2QI9 http://www.ebi.ac.uk/pdbe-srv/view/entry/2QI9 PDB 4DBL http://www.ebi.ac.uk/pdbe-srv/view/entry/4DBL PDB 4FI3 http://www.ebi.ac.uk/pdbe-srv/view/entry/4FI3 PDBsum 1N2Z http://www.ebi.ac.uk/pdbsum/1N2Z PDBsum 1N4A http://www.ebi.ac.uk/pdbsum/1N4A PDBsum 1N4D http://www.ebi.ac.uk/pdbsum/1N4D PDBsum 2QI9 http://www.ebi.ac.uk/pdbsum/2QI9 PDBsum 4DBL http://www.ebi.ac.uk/pdbsum/4DBL PDBsum 4FI3 http://www.ebi.ac.uk/pdbsum/4FI3 PROSITE PS50983 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50983 PSORT swissprot:BTUF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BTUF_ECOLI PSORT-B swissprot:BTUF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BTUF_ECOLI PSORT2 swissprot:BTUF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BTUF_ECOLI Pfam PF01497 http://pfam.xfam.org/family/PF01497 Phobius swissprot:BTUF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BTUF_ECOLI PhylomeDB P37028 http://phylomedb.org/?seqid=P37028 ProteinModelPortal P37028 http://www.proteinmodelportal.org/query/uniprot/P37028 PubMed 11790740 http://www.ncbi.nlm.nih.gov/pubmed/11790740 PubMed 12468528 http://www.ncbi.nlm.nih.gov/pubmed/12468528 PubMed 12475936 http://www.ncbi.nlm.nih.gov/pubmed/12475936 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414700 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414700 RefSeq WP_001129927 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001129927 SMR P37028 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37028 STRING 511145.b0158 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0158&targetmode=cogs STRING COG0614 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0614&targetmode=cogs UniProtKB BTUF_ECOLI http://www.uniprot.org/uniprot/BTUF_ECOLI UniProtKB-AC P37028 http://www.uniprot.org/uniprot/P37028 charge swissprot:BTUF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BTUF_ECOLI eggNOG COG0614 http://eggnogapi.embl.de/nog_data/html/tree/COG0614 eggNOG ENOG4105JKQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105JKQ epestfind swissprot:BTUF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BTUF_ECOLI garnier swissprot:BTUF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BTUF_ECOLI helixturnhelix swissprot:BTUF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BTUF_ECOLI hmoment swissprot:BTUF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BTUF_ECOLI iep swissprot:BTUF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BTUF_ECOLI inforesidue swissprot:BTUF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BTUF_ECOLI octanol swissprot:BTUF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BTUF_ECOLI pepcoil swissprot:BTUF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BTUF_ECOLI pepdigest swissprot:BTUF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BTUF_ECOLI pepinfo swissprot:BTUF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BTUF_ECOLI pepnet swissprot:BTUF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BTUF_ECOLI pepstats swissprot:BTUF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BTUF_ECOLI pepwheel swissprot:BTUF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BTUF_ECOLI pepwindow swissprot:BTUF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BTUF_ECOLI sigcleave swissprot:BTUF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BTUF_ECOLI ## Database ID URL or Descriptions # BioGrid 4262376 6 # EcoGene EG11800 hybB # FUNCTION HYBB_ECOLI Probable b-type cytochrome. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; ISM:EcoCyc. # GO_component GO:0016021 integral component of membrane; IBA:GO_Central. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0055114 oxidation-reduction process; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # InterPro IPR005614 NrfD_fam # Organism HYBB_ECOLI Escherichia coli (strain K12) # PATRIC 32121406 VBIEscCol129921_3090 # PIR A65086 A65086 # Pfam PF03916 NrfD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HYBB_ECOLI Probable Ni/Fe-hydrogenase 2 b-type cytochrome subunit # RefSeq NP_417469 NC_000913.3 # RefSeq WP_000017703 NZ_LN832404.1 # SIMILARITY Belongs to the NrfD family. {ECO 0000305}. # SUBCELLULAR LOCATION HYBB_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG COG5557 LUCA # eggNOG ENOG4105CJ5 Bacteria BLAST swissprot:HYBB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HYBB_ECOLI BioCyc ECOL316407:JW5494-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5494-MONOMER BioCyc EcoCyc:EG11800-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11800-MONOMER BioCyc MetaCyc:EG11800-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11800-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U09177 http://www.ebi.ac.uk/ena/data/view/U09177 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB1748 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1748 EcoGene EG11800 http://www.ecogene.org/geneInfo.php?eg_id=EG11800 EnsemblBacteria AAC76031 http://www.ensemblgenomes.org/id/AAC76031 EnsemblBacteria AAC76031 http://www.ensemblgenomes.org/id/AAC76031 EnsemblBacteria BAE77056 http://www.ensemblgenomes.org/id/BAE77056 EnsemblBacteria BAE77056 http://www.ensemblgenomes.org/id/BAE77056 EnsemblBacteria BAE77056 http://www.ensemblgenomes.org/id/BAE77056 EnsemblBacteria b2995 http://www.ensemblgenomes.org/id/b2995 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0055114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 948615 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948615 HOGENOM HOG000278811 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278811&db=HOGENOM6 InParanoid P37180 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37180 InterPro IPR005614 http://www.ebi.ac.uk/interpro/entry/IPR005614 KEGG_Gene ecj:JW5494 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5494 KEGG_Gene eco:b2995 http://www.genome.jp/dbget-bin/www_bget?eco:b2995 OMA AIEVCAY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AIEVCAY PSORT swissprot:HYBB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HYBB_ECOLI PSORT-B swissprot:HYBB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HYBB_ECOLI PSORT2 swissprot:HYBB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HYBB_ECOLI Pfam PF03916 http://pfam.xfam.org/family/PF03916 Phobius swissprot:HYBB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HYBB_ECOLI PhylomeDB P37180 http://phylomedb.org/?seqid=P37180 ProteinModelPortal P37180 http://www.proteinmodelportal.org/query/uniprot/P37180 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8021226 http://www.ncbi.nlm.nih.gov/pubmed/8021226 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417469 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417469 RefSeq WP_000017703 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000017703 STRING 511145.b2995 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2995&targetmode=cogs UniProtKB HYBB_ECOLI http://www.uniprot.org/uniprot/HYBB_ECOLI UniProtKB-AC P37180 http://www.uniprot.org/uniprot/P37180 charge swissprot:HYBB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HYBB_ECOLI eggNOG COG5557 http://eggnogapi.embl.de/nog_data/html/tree/COG5557 eggNOG ENOG4105CJ5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CJ5 epestfind swissprot:HYBB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HYBB_ECOLI garnier swissprot:HYBB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HYBB_ECOLI helixturnhelix swissprot:HYBB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HYBB_ECOLI hmoment swissprot:HYBB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HYBB_ECOLI iep swissprot:HYBB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HYBB_ECOLI inforesidue swissprot:HYBB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HYBB_ECOLI octanol swissprot:HYBB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HYBB_ECOLI pepcoil swissprot:HYBB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HYBB_ECOLI pepdigest swissprot:HYBB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HYBB_ECOLI pepinfo swissprot:HYBB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HYBB_ECOLI pepnet swissprot:HYBB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HYBB_ECOLI pepstats swissprot:HYBB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HYBB_ECOLI pepwheel swissprot:HYBB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HYBB_ECOLI pepwindow swissprot:HYBB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HYBB_ECOLI sigcleave swissprot:HYBB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HYBB_ECOLI ## Database ID URL or Descriptions # BioGrid 4261696 4 # EcoGene EG13818 yneJ # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; ISS:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # IntAct P77309 2 # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR005119 LysR_subst-bd # InterPro IPR011991 WHTH_DNA-bd_dom # Organism YNEJ_ECOLI Escherichia coli (strain K12) # PATRIC 32118350 VBIEscCol129921_1595 # PIR A64907 A64907 # PROSITE PS50931 HTH_LYSR # Pfam PF00126 HTH_1 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNEJ_ECOLI Uncharacterized HTH-type transcriptional regulator YneJ # RefSeq NP_416043 NC_000913.3 # RefSeq WP_000366501 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lysR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00253}. # SUPFAM SSF46785 SSF46785 # eggNOG ENOG4105EGI Bacteria # eggNOG ENOG410XR3F LUCA BLAST swissprot:YNEJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNEJ_ECOLI BioCyc ECOL316407:JW1519-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1519-MONOMER BioCyc EcoCyc:G6812-MONOMER http://biocyc.org/getid?id=EcoCyc:G6812-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3579 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3579 EcoGene EG13818 http://www.ecogene.org/geneInfo.php?eg_id=EG13818 EnsemblBacteria AAC74599 http://www.ensemblgenomes.org/id/AAC74599 EnsemblBacteria AAC74599 http://www.ensemblgenomes.org/id/AAC74599 EnsemblBacteria BAA15209 http://www.ensemblgenomes.org/id/BAA15209 EnsemblBacteria BAA15209 http://www.ensemblgenomes.org/id/BAA15209 EnsemblBacteria BAA15209 http://www.ensemblgenomes.org/id/BAA15209 EnsemblBacteria b1526 http://www.ensemblgenomes.org/id/b1526 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 946079 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946079 HOGENOM HOG000233521 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000233521&db=HOGENOM6 InParanoid P77309 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77309 IntAct P77309 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77309* InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW1519 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1519 KEGG_Gene eco:b1526 http://www.genome.jp/dbget-bin/www_bget?eco:b1526 OMA FRSNCSY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FRSNCSY PROSITE PS50931 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50931 PSORT swissprot:YNEJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNEJ_ECOLI PSORT-B swissprot:YNEJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNEJ_ECOLI PSORT2 swissprot:YNEJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNEJ_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:YNEJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNEJ_ECOLI PhylomeDB P77309 http://phylomedb.org/?seqid=P77309 ProteinModelPortal P77309 http://www.proteinmodelportal.org/query/uniprot/P77309 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416043 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416043 RefSeq WP_000366501 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000366501 SMR P77309 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77309 STRING 511145.b1526 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1526&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB YNEJ_ECOLI http://www.uniprot.org/uniprot/YNEJ_ECOLI UniProtKB-AC P77309 http://www.uniprot.org/uniprot/P77309 charge swissprot:YNEJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNEJ_ECOLI eggNOG ENOG4105EGI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EGI eggNOG ENOG410XR3F http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XR3F epestfind swissprot:YNEJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNEJ_ECOLI garnier swissprot:YNEJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNEJ_ECOLI helixturnhelix swissprot:YNEJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNEJ_ECOLI hmoment swissprot:YNEJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNEJ_ECOLI iep swissprot:YNEJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNEJ_ECOLI inforesidue swissprot:YNEJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNEJ_ECOLI octanol swissprot:YNEJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNEJ_ECOLI pepcoil swissprot:YNEJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNEJ_ECOLI pepdigest swissprot:YNEJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNEJ_ECOLI pepinfo swissprot:YNEJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNEJ_ECOLI pepnet swissprot:YNEJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNEJ_ECOLI pepstats swissprot:YNEJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNEJ_ECOLI pepwheel swissprot:YNEJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNEJ_ECOLI pepwindow swissprot:YNEJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNEJ_ECOLI sigcleave swissprot:YNEJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNEJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4262665 11 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG11927 yjbI # Gene3D 3.80.10.10 -; 2. # InterPro IPR001646 5peptide_repeat # InterPro IPR025726 SopA-like_central # InterPro IPR032675 L_dom-like # Organism YJBI_ECOLI Escherichia coli (strain K12) # PATRIC 48667621 VBIEscCol107702_4070 # PIR E65211 E65211 # Pfam PF13599 Pentapeptide_4 # Pfam PF13981 SopA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJBI_ECOLI Putative uncharacterized protein YjbI # RefSeq WP_001311302 NZ_LN832404.1 # eggNOG COG1357 LUCA BLAST swissprot:YJBI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJBI_ECOLI BioCyc ECOL316407:JW3998-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3998-MONOMER BioCyc EcoCyc:EG11927-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11927-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1099/00221287-139-8-1795 http://dx.doi.org/10.1099/00221287-139-8-1795 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M96268 http://www.ebi.ac.uk/ena/data/view/M96268 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1871 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1871 EcoGene EG11927 http://www.ecogene.org/geneInfo.php?eg_id=EG11927 EnsemblBacteria BAE78040 http://www.ensemblgenomes.org/id/BAE78040 EnsemblBacteria BAE78040 http://www.ensemblgenomes.org/id/BAE78040 EnsemblBacteria BAE78040 http://www.ensemblgenomes.org/id/BAE78040 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.80.10.10 http://www.cathdb.info/version/latest/superfamily/3.80.10.10 HOGENOM HOG000009806 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009806&db=HOGENOM6 IntAct P32690 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32690* InterPro IPR001646 http://www.ebi.ac.uk/interpro/entry/IPR001646 InterPro IPR025726 http://www.ebi.ac.uk/interpro/entry/IPR025726 InterPro IPR032675 http://www.ebi.ac.uk/interpro/entry/IPR032675 KEGG_Gene ecj:JW3998 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3998 OMA CNFTTAT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CNFTTAT PSORT swissprot:YJBI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJBI_ECOLI PSORT-B swissprot:YJBI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJBI_ECOLI PSORT2 swissprot:YJBI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJBI_ECOLI Pfam PF13599 http://pfam.xfam.org/family/PF13599 Pfam PF13981 http://pfam.xfam.org/family/PF13981 Phobius swissprot:YJBI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJBI_ECOLI ProteinModelPortal P32690 http://www.proteinmodelportal.org/query/uniprot/P32690 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 8409922 http://www.ncbi.nlm.nih.gov/pubmed/8409922 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001311302 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001311302 STRING 316407.85676790 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85676790&targetmode=cogs UniProtKB YJBI_ECOLI http://www.uniprot.org/uniprot/YJBI_ECOLI UniProtKB-AC P32690 http://www.uniprot.org/uniprot/P32690 charge swissprot:YJBI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJBI_ECOLI eggNOG COG1357 http://eggnogapi.embl.de/nog_data/html/tree/COG1357 epestfind swissprot:YJBI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJBI_ECOLI garnier swissprot:YJBI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJBI_ECOLI helixturnhelix swissprot:YJBI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJBI_ECOLI hmoment swissprot:YJBI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJBI_ECOLI iep swissprot:YJBI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJBI_ECOLI inforesidue swissprot:YJBI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJBI_ECOLI octanol swissprot:YJBI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJBI_ECOLI pepcoil swissprot:YJBI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJBI_ECOLI pepdigest swissprot:YJBI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJBI_ECOLI pepinfo swissprot:YJBI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJBI_ECOLI pepnet swissprot:YJBI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJBI_ECOLI pepstats swissprot:YJBI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJBI_ECOLI pepwheel swissprot:YJBI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJBI_ECOLI pepwindow swissprot:YJBI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJBI_ECOLI sigcleave swissprot:YJBI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJBI_ECOLI ## Database ID URL or Descriptions # BioGrid 4260965 3 # EcoGene EG11849 yihW # FUNCTION YIHW_ECOLI Could be involved in the transcriptional regulation of the sulfoquinovose operon. {ECO 0000269|PubMed 24463506}. # GO_component GO:0005622 intracellular; IEA:InterPro. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; ISS:EcoCyc. # GOslim_component GO:0005622 intracellular # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # InterPro IPR001034 DeoR_HTH # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR014036 DeoR_C # InterPro IPR018356 Tscrpt_reg_HTH_DeoR_CS # Organism YIHW_ECOLI Escherichia coli (strain K12) # PATRIC 32123271 VBIEscCol129921_3996 # PRINTS PR00037 HTHLACR # PROSITE PS00894 HTH_DEOR_1 # PROSITE PS51000 HTH_DEOR_2 # Pfam PF00455 DeoRC # Pfam PF08220 HTH_DeoR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIHW_ECOLI Uncharacterized HTH-type transcriptional regulator YihW # RefSeq NP_418320 NC_000913.3 # RefSeq WP_000059678 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB03017.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Contains 1 HTH deoR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00349}. # SMART SM00420 HTH_DEOR # SUPFAM SSF46785 SSF46785 # eggNOG COG1349 LUCA # eggNOG ENOG4105E98 Bacteria BLAST swissprot:YIHW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIHW_ECOLI BioCyc ECOL316407:JW5567-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5567-MONOMER BioCyc EcoCyc:EG11849-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11849-MONOMER DIP DIP-12504N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12504N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature12947 http://dx.doi.org/10.1038/nature12947 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1795 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1795 EcoGene EG11849 http://www.ecogene.org/geneInfo.php?eg_id=EG11849 EnsemblBacteria AAD13446 http://www.ensemblgenomes.org/id/AAD13446 EnsemblBacteria AAD13446 http://www.ensemblgenomes.org/id/AAD13446 EnsemblBacteria BAE77425 http://www.ensemblgenomes.org/id/BAE77425 EnsemblBacteria BAE77425 http://www.ensemblgenomes.org/id/BAE77425 EnsemblBacteria BAE77425 http://www.ensemblgenomes.org/id/BAE77425 EnsemblBacteria b3884 http://www.ensemblgenomes.org/id/b3884 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 948381 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948381 HOGENOM HOG000224685 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000224685&db=HOGENOM6 InParanoid P32144 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32144 InterPro IPR001034 http://www.ebi.ac.uk/interpro/entry/IPR001034 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR014036 http://www.ebi.ac.uk/interpro/entry/IPR014036 InterPro IPR018356 http://www.ebi.ac.uk/interpro/entry/IPR018356 KEGG_Gene ecj:JW5567 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5567 KEGG_Gene eco:b3884 http://www.genome.jp/dbget-bin/www_bget?eco:b3884 MINT MINT-1301395 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1301395 OMA PHNGGII http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PHNGGII PRINTS PR00037 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00037 PROSITE PS00894 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00894 PROSITE PS51000 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51000 PSORT swissprot:YIHW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIHW_ECOLI PSORT-B swissprot:YIHW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIHW_ECOLI PSORT2 swissprot:YIHW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIHW_ECOLI Pfam PF00455 http://pfam.xfam.org/family/PF00455 Pfam PF08220 http://pfam.xfam.org/family/PF08220 Phobius swissprot:YIHW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIHW_ECOLI PhylomeDB P32144 http://phylomedb.org/?seqid=P32144 ProteinModelPortal P32144 http://www.proteinmodelportal.org/query/uniprot/P32144 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 24463506 http://www.ncbi.nlm.nih.gov/pubmed/24463506 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418320 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418320 RefSeq WP_000059678 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000059678 SMART SM00420 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00420 SMR P32144 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32144 STRING 511145.b3884 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3884&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB YIHW_ECOLI http://www.uniprot.org/uniprot/YIHW_ECOLI UniProtKB-AC P32144 http://www.uniprot.org/uniprot/P32144 charge swissprot:YIHW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIHW_ECOLI eggNOG COG1349 http://eggnogapi.embl.de/nog_data/html/tree/COG1349 eggNOG ENOG4105E98 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E98 epestfind swissprot:YIHW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIHW_ECOLI garnier swissprot:YIHW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIHW_ECOLI helixturnhelix swissprot:YIHW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIHW_ECOLI hmoment swissprot:YIHW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIHW_ECOLI iep swissprot:YIHW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIHW_ECOLI inforesidue swissprot:YIHW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIHW_ECOLI octanol swissprot:YIHW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIHW_ECOLI pepcoil swissprot:YIHW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIHW_ECOLI pepdigest swissprot:YIHW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIHW_ECOLI pepinfo swissprot:YIHW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIHW_ECOLI pepnet swissprot:YIHW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIHW_ECOLI pepstats swissprot:YIHW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIHW_ECOLI pepwheel swissprot:YIHW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIHW_ECOLI pepwindow swissprot:YIHW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIHW_ECOLI sigcleave swissprot:YIHW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIHW_ECOLI ## Database ID URL or Descriptions # BioGrid 4260159 68 # EcoGene EG13364 ydaV # GO_function GO:0005524 ATP binding; IEA:InterPro. # GO_function GO:0043565 sequence-specific DNA binding; IBA:GO_Central. # GO_process GO:0006260 DNA replication; IBA:GO_Central. # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.300 -; 1. # IntAct P77546 2 # InterPro IPR002611 IstB_ATP-bd # InterPro IPR027417 P-loop_NTPase # InterPro IPR028350 DNAC/ATP-binding # Organism YDAV_ECOLI Escherichia coli (strain K12) # PATRIC 32117998 VBIEscCol129921_1419 # PIR C64886 C64886 # PIRSF PIRSF003073 DNAC_TnpB_IstB # Pfam PF01695 IstB_IS21 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDAV_ECOLI Uncharacterized protein YdaV # RefSeq NP_415878 NC_000913.3 # RefSeq WP_000788970 NZ_CP014272.1 # SUPFAM SSF52540 SSF52540 # eggNOG ENOG4105JBR Bacteria # eggNOG ENOG4111QIU LUCA BLAST swissprot:YDAV_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDAV_ECOLI BioCyc ECOL316407:JW1355-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1355-MONOMER BioCyc EcoCyc:G6684-MONOMER http://biocyc.org/getid?id=EcoCyc:G6684-MONOMER COG COG1484 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1484 DIP DIP-48163N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48163N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3147 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3147 EcoGene EG13364 http://www.ecogene.org/geneInfo.php?eg_id=EG13364 EnsemblBacteria AAC74442 http://www.ensemblgenomes.org/id/AAC74442 EnsemblBacteria AAC74442 http://www.ensemblgenomes.org/id/AAC74442 EnsemblBacteria BAA14958 http://www.ensemblgenomes.org/id/BAA14958 EnsemblBacteria BAA14958 http://www.ensemblgenomes.org/id/BAA14958 EnsemblBacteria BAA14958 http://www.ensemblgenomes.org/id/BAA14958 EnsemblBacteria b1360 http://www.ensemblgenomes.org/id/b1360 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945926 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945926 HOGENOM HOG000120230 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120230&db=HOGENOM6 InParanoid P77546 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77546 IntAct P77546 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77546* InterPro IPR002611 http://www.ebi.ac.uk/interpro/entry/IPR002611 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR028350 http://www.ebi.ac.uk/interpro/entry/IPR028350 KEGG_Gene ecj:JW1355 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1355 KEGG_Gene eco:b1360 http://www.genome.jp/dbget-bin/www_bget?eco:b1360 KEGG_Orthology KO:K10762 http://www.genome.jp/dbget-bin/www_bget?KO:K10762 OMA WISHERC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WISHERC PSORT swissprot:YDAV_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDAV_ECOLI PSORT-B swissprot:YDAV_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDAV_ECOLI PSORT2 swissprot:YDAV_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDAV_ECOLI Pfam PF01695 http://pfam.xfam.org/family/PF01695 Phobius swissprot:YDAV_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDAV_ECOLI ProteinModelPortal P77546 http://www.proteinmodelportal.org/query/uniprot/P77546 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415878 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415878 RefSeq WP_000788970 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000788970 SMR P77546 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77546 STRING 511145.b1360 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1360&targetmode=cogs STRING COG1484 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1484&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB YDAV_ECOLI http://www.uniprot.org/uniprot/YDAV_ECOLI UniProtKB-AC P77546 http://www.uniprot.org/uniprot/P77546 charge swissprot:YDAV_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDAV_ECOLI eggNOG ENOG4105JBR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105JBR eggNOG ENOG4111QIU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111QIU epestfind swissprot:YDAV_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDAV_ECOLI garnier swissprot:YDAV_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDAV_ECOLI helixturnhelix swissprot:YDAV_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDAV_ECOLI hmoment swissprot:YDAV_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDAV_ECOLI iep swissprot:YDAV_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDAV_ECOLI inforesidue swissprot:YDAV_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDAV_ECOLI octanol swissprot:YDAV_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDAV_ECOLI pepcoil swissprot:YDAV_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDAV_ECOLI pepdigest swissprot:YDAV_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDAV_ECOLI pepinfo swissprot:YDAV_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDAV_ECOLI pepnet swissprot:YDAV_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDAV_ECOLI pepstats swissprot:YDAV_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDAV_ECOLI pepwheel swissprot:YDAV_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDAV_ECOLI pepwindow swissprot:YDAV_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDAV_ECOLI sigcleave swissprot:YDAV_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDAV_ECOLI ## Database ID URL or Descriptions # AltName CITE_ECOLI Citrate (pro-3S)-lyase subunit beta # AltName CITE_ECOLI Citryl-CoA lyase subunit # BioGrid 4261999 12 # CATALYTIC ACTIVITY CITE_ECOLI (3S)-citryl-CoA = acetyl-CoA + oxaloacetate. # CATALYTIC ACTIVITY CITE_ECOLI Citrate = acetate + oxaloacetate. # COFACTOR CITE_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250}; Note=Binds 1 Mg(2+) ion per subunit. {ECO 0000250}; # EcoGene EG13542 citE # FUNCTION CITE_ECOLI Represents a citryl-ACP lyase. {ECO 0000250}. # GO_component GO:0009346 citrate lyase complex; IEA:InterPro. # GO_function GO:0000287 magnesium ion binding; IBA:GO_Central. # GO_function GO:0008815 citrate (pro-3S)-lyase activity; IEA:UniProtKB-EC. # GO_function GO:0008816 citryl-CoA lyase activity; IEA:UniProtKB-EC. # GO_process GO:0006084 acetyl-CoA metabolic process; IEA:InterPro. # GO_process GO:0006107 oxaloacetate metabolic process; IBA:GO_Central. # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.20.20.60 -; 1. # INDUCTION Repressed by H-NS. Part of the citCDEFXG operon. {ECO:0000269|PubMed 19429622}. # IntAct P0A9I1 9 # InterPro IPR005000 Aldolase/citrate-lyase_domain # InterPro IPR006475 Citrate_lyase_beta_bac # InterPro IPR011206 Citrate_lyase_beta/mcl1/mcl2 # InterPro IPR015813 Pyrv/PenolPyrv_Kinase-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00020 Citrate cycle (TCA cycle) # KEGG_Pathway ko02020 Two-component system # Organism CITE_ECOLI Escherichia coli (strain K12) # PANTHER PTHR32308 PTHR32308 # PATRIC 32116412 VBIEscCol129921_0646 # PIR F64795 F64795 # PIRSF PIRSF015582 Cit_lyase_B # Pfam PF03328 HpcH_HpaI # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CITE_ECOLI Citrate lyase subunit beta # RefSeq NP_415149 NC_000913.3 # RefSeq WP_000622357 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40816.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the HpcH/HpaI aldolase family. Citrate lyase beta subunit subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION CITE_ECOLI Cytoplasm. # SUBUNIT Oligomer with a subunit composition of (alpha,beta, gamma)6. {ECO 0000250}. # SUPFAM SSF51621 SSF51621 # TIGRFAMs TIGR01588 citE # eggNOG COG2301 LUCA # eggNOG ENOG4105CI0 Bacteria BLAST swissprot:CITE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CITE_ECOLI BioCyc ECOL316407:JW0608-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0608-MONOMER BioCyc EcoCyc:CITRYLY-MONOMER http://biocyc.org/getid?id=EcoCyc:CITRYLY-MONOMER BioCyc MetaCyc:CITRYLY-MONOMER http://biocyc.org/getid?id=MetaCyc:CITRYLY-MONOMER COG COG2301 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2301 DIP DIP-9285N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9285N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00108-09 http://dx.doi.org/10.1128/JB.00108-09 EC_number EC:4.1.3.34 http://www.genome.jp/dbget-bin/www_bget?EC:4.1.3.34 EC_number EC:4.1.3.6 http://www.genome.jp/dbget-bin/www_bget?EC:4.1.3.6 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U46667 http://www.ebi.ac.uk/ena/data/view/U46667 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 ENZYME 4.1.3.34 http://enzyme.expasy.org/EC/4.1.3.34 ENZYME 4.1.3.6 http://enzyme.expasy.org/EC/4.1.3.6 EchoBASE EB3312 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3312 EcoGene EG13542 http://www.ecogene.org/geneInfo.php?eg_id=EG13542 EnsemblBacteria AAC73717 http://www.ensemblgenomes.org/id/AAC73717 EnsemblBacteria AAC73717 http://www.ensemblgenomes.org/id/AAC73717 EnsemblBacteria BAA35252 http://www.ensemblgenomes.org/id/BAA35252 EnsemblBacteria BAA35252 http://www.ensemblgenomes.org/id/BAA35252 EnsemblBacteria BAA35252 http://www.ensemblgenomes.org/id/BAA35252 EnsemblBacteria b0616 http://www.ensemblgenomes.org/id/b0616 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009346 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009346 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0008815 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008815 GO_function GO:0008816 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008816 GO_process GO:0006084 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006084 GO_process GO:0006107 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006107 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.20.20.60 http://www.cathdb.info/version/latest/superfamily/3.20.20.60 GeneID 945406 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945406 HOGENOM HOG000242282 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000242282&db=HOGENOM6 InParanoid P0A9I1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9I1 IntAct P0A9I1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9I1* IntEnz 4.1.3.34 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.3.34 IntEnz 4.1.3.6 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.3.6 InterPro IPR005000 http://www.ebi.ac.uk/interpro/entry/IPR005000 InterPro IPR006475 http://www.ebi.ac.uk/interpro/entry/IPR006475 InterPro IPR011206 http://www.ebi.ac.uk/interpro/entry/IPR011206 InterPro IPR015813 http://www.ebi.ac.uk/interpro/entry/IPR015813 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0608 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0608 KEGG_Gene eco:b0616 http://www.genome.jp/dbget-bin/www_bget?eco:b0616 KEGG_Orthology KO:K01644 http://www.genome.jp/dbget-bin/www_bget?KO:K01644 KEGG_Pathway ko00020 http://www.genome.jp/kegg-bin/show_pathway?ko00020 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 KEGG_Reaction rn:R00362 http://www.genome.jp/dbget-bin/www_bget?rn:R00362 MINT MINT-1283346 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1283346 OMA MALNKMS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MALNKMS PANTHER PTHR32308 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32308 PSORT swissprot:CITE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CITE_ECOLI PSORT-B swissprot:CITE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CITE_ECOLI PSORT2 swissprot:CITE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CITE_ECOLI Pfam PF03328 http://pfam.xfam.org/family/PF03328 Phobius swissprot:CITE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CITE_ECOLI PhylomeDB P0A9I1 http://phylomedb.org/?seqid=P0A9I1 ProteinModelPortal P0A9I1 http://www.proteinmodelportal.org/query/uniprot/P0A9I1 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19429622 http://www.ncbi.nlm.nih.gov/pubmed/19429622 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415149 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415149 RefSeq WP_000622357 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000622357 SMR P0A9I1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9I1 STRING 511145.b0616 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0616&targetmode=cogs STRING COG2301 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2301&targetmode=cogs SUPFAM SSF51621 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51621 TIGRFAMs TIGR01588 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01588 UniProtKB CITE_ECOLI http://www.uniprot.org/uniprot/CITE_ECOLI UniProtKB-AC P0A9I1 http://www.uniprot.org/uniprot/P0A9I1 charge swissprot:CITE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CITE_ECOLI eggNOG COG2301 http://eggnogapi.embl.de/nog_data/html/tree/COG2301 eggNOG ENOG4105CI0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CI0 epestfind swissprot:CITE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CITE_ECOLI garnier swissprot:CITE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CITE_ECOLI helixturnhelix swissprot:CITE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CITE_ECOLI hmoment swissprot:CITE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CITE_ECOLI iep swissprot:CITE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CITE_ECOLI inforesidue swissprot:CITE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CITE_ECOLI octanol swissprot:CITE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CITE_ECOLI pepcoil swissprot:CITE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CITE_ECOLI pepdigest swissprot:CITE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CITE_ECOLI pepinfo swissprot:CITE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CITE_ECOLI pepnet swissprot:CITE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CITE_ECOLI pepstats swissprot:CITE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CITE_ECOLI pepwheel swissprot:CITE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CITE_ECOLI pepwindow swissprot:CITE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CITE_ECOLI sigcleave swissprot:CITE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CITE_ECOLI ## Database ID URL or Descriptions # BioGrid 4262133 267 # EcoGene EG12850 yfaL # GO_component GO:0019867 outer membrane; IEA:InterPro. # GO_process GO:0043708 cell adhesion involved in biofilm formation; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0007155 cell adhesion # Gene3D 2.160.20.20 -; 1. # Gene3D 2.40.128.130 -; 1. # IntAct P45508 6 # InterPro IPR003368 POMP_repeat # InterPro IPR005546 Autotransporte_beta # InterPro IPR006315 OM_autotransptr_brl # InterPro IPR011050 Pectin_lyase_fold/virulence # InterPro IPR012332 P22_tailspike_C-like # InterPro IPR013425 Autotrns_rpt # Organism YFAL_ECOLI Escherichia coli (strain K12) # PATRIC 32119825 VBIEscCol129921_2322 # PIR G64993 G64993 # PROSITE PS51208 AUTOTRANSPORTER # Pfam PF02415 Chlam_PMP; 3 # Pfam PF03797 Autotransporter # Pfam PF12951 PATR; 3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFAL_ECOLI Uncharacterized protein YfaL # RefSeq NP_416736 NC_000913.3 # RefSeq WP_001220077 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=K02672; Type=Frameshift; Positions=Several; Evidence={ECO 0000305}; # SIMILARITY Contains 1 autotransporter (TC 1.B.12) domain. {ECO:0000255|PROSITE-ProRule PRU00556}. # SMART SM00869 Autotransporter # SUPFAM SSF103515 SSF103515 # SUPFAM SSF51126 SSF51126; 2 # TCDB 1.B.12.1 the autotransporter-1 (at-1) family # TIGRFAMs TIGR01376 POMP_repeat; 2 # TIGRFAMs TIGR01414 autotrans_barl # TIGRFAMs TIGR02601 autotrns_rpt # eggNOG COG3468 LUCA # eggNOG ENOG4107GHC Bacteria BLAST swissprot:YFAL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFAL_ECOLI BioCyc ECOL316407:JW2227-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2227-MONOMER BioCyc EcoCyc:EG12850-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12850-MONOMER COG COG3468 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3468 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.81.14.4294 http://dx.doi.org/10.1073/pnas.81.14.4294 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1111/j.1365-2958.1987.tb01932.x http://dx.doi.org/10.1111/j.1365-2958.1987.tb01932.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K02672 http://www.ebi.ac.uk/ena/data/view/K02672 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U30459 http://www.ebi.ac.uk/ena/data/view/U30459 EMBL Y00544 http://www.ebi.ac.uk/ena/data/view/Y00544 EchoBASE EB2695 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2695 EcoGene EG12850 http://www.ecogene.org/geneInfo.php?eg_id=EG12850 EnsemblBacteria AAC75293 http://www.ensemblgenomes.org/id/AAC75293 EnsemblBacteria AAC75293 http://www.ensemblgenomes.org/id/AAC75293 EnsemblBacteria BAA16050 http://www.ensemblgenomes.org/id/BAA16050 EnsemblBacteria BAA16050 http://www.ensemblgenomes.org/id/BAA16050 EnsemblBacteria BAA16050 http://www.ensemblgenomes.org/id/BAA16050 EnsemblBacteria b2233 http://www.ensemblgenomes.org/id/b2233 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0019867 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019867 GO_process GO:0043708 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043708 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 Gene3D 2.160.20.20 http://www.cathdb.info/version/latest/superfamily/2.160.20.20 Gene3D 2.40.128.130 http://www.cathdb.info/version/latest/superfamily/2.40.128.130 GeneID 946595 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946595 HOGENOM HOG000122378 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122378&db=HOGENOM6 IntAct P45508 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45508* InterPro IPR003368 http://www.ebi.ac.uk/interpro/entry/IPR003368 InterPro IPR005546 http://www.ebi.ac.uk/interpro/entry/IPR005546 InterPro IPR006315 http://www.ebi.ac.uk/interpro/entry/IPR006315 InterPro IPR011050 http://www.ebi.ac.uk/interpro/entry/IPR011050 InterPro IPR012332 http://www.ebi.ac.uk/interpro/entry/IPR012332 InterPro IPR013425 http://www.ebi.ac.uk/interpro/entry/IPR013425 KEGG_Gene ecj:JW2227 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2227 KEGG_Gene eco:b2233 http://www.genome.jp/dbget-bin/www_bget?eco:b2233 KEGG_Orthology KO:K07279 http://www.genome.jp/dbget-bin/www_bget?KO:K07279 OMA IKASCQA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IKASCQA PROSITE PS51208 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51208 PSORT swissprot:YFAL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFAL_ECOLI PSORT-B swissprot:YFAL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFAL_ECOLI PSORT2 swissprot:YFAL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFAL_ECOLI Pfam PF02415 http://pfam.xfam.org/family/PF02415 Pfam PF03797 http://pfam.xfam.org/family/PF03797 Pfam PF12951 http://pfam.xfam.org/family/PF12951 Phobius swissprot:YFAL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFAL_ECOLI PhylomeDB P45508 http://phylomedb.org/?seqid=P45508 ProteinModelPortal P45508 http://www.proteinmodelportal.org/query/uniprot/P45508 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2834621 http://www.ncbi.nlm.nih.gov/pubmed/2834621 PubMed 6087316 http://www.ncbi.nlm.nih.gov/pubmed/6087316 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416736 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416736 RefSeq WP_001220077 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001220077 SMART SM00869 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00869 SMR P45508 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45508 STRING 511145.b2233 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2233&targetmode=cogs STRING COG3468 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3468&targetmode=cogs SUPFAM SSF103515 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103515 SUPFAM SSF51126 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51126 TCDB 1.B.12.1 http://www.tcdb.org/search/result.php?tc=1.B.12.1 TIGRFAMs TIGR01376 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01376 TIGRFAMs TIGR01414 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01414 TIGRFAMs TIGR02601 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02601 UniProtKB YFAL_ECOLI http://www.uniprot.org/uniprot/YFAL_ECOLI UniProtKB-AC P45508 http://www.uniprot.org/uniprot/P45508 charge swissprot:YFAL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFAL_ECOLI eggNOG COG3468 http://eggnogapi.embl.de/nog_data/html/tree/COG3468 eggNOG ENOG4107GHC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107GHC epestfind swissprot:YFAL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFAL_ECOLI garnier swissprot:YFAL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFAL_ECOLI helixturnhelix swissprot:YFAL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFAL_ECOLI hmoment swissprot:YFAL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFAL_ECOLI iep swissprot:YFAL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFAL_ECOLI inforesidue swissprot:YFAL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFAL_ECOLI octanol swissprot:YFAL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFAL_ECOLI pepcoil swissprot:YFAL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFAL_ECOLI pepdigest swissprot:YFAL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFAL_ECOLI pepinfo swissprot:YFAL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFAL_ECOLI pepnet swissprot:YFAL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFAL_ECOLI pepstats swissprot:YFAL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFAL_ECOLI pepwheel swissprot:YFAL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFAL_ECOLI pepwindow swissprot:YFAL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFAL_ECOLI sigcleave swissprot:YFAL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFAL_ECOLI ## Database ID URL or Descriptions # AltName UIDB2_ECOLI Glucuronide permease # FUNCTION UIDB2_ECOLI Responsible for the transport of glucuronide into the cell energized by the proton motive force (probably by symport). Import is enhanced by UidC (GusC, AC Q47706). # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015293 symporter activity; IEA:UniProtKB-KW. # GO_process GO:0006814 sodium ion transport; IEA:InterPro. # GO_process GO:0008643 carbohydrate transport; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # INDUCTION In the presence of glucuronides. {ECO:0000269|PubMed 15774881}. # InterPro IPR001927 Na/Gal_symport # InterPro IPR018043 Na/Gal_symport_CS # InterPro IPR020846 MFS_dom # MISCELLANEOUS UIDB2_ECOLI In some K12 strains, the protein is inactive for transport, probably due to a mutation at position 100. # Organism UIDB2_ECOLI Escherichia coli (strain K12) # PROSITE PS00872 NA_GALACTOSIDE_SYMP # RecName UIDB2_ECOLI Glucuronide carrier protein # SIMILARITY Belongs to the sodium:galactoside symporter (TC 2.A.2) family. {ECO 0000305}. # SUBCELLULAR LOCATION UIDB2_ECOLI Cell inner membrane {ECO 0000269|PubMed 15774881}; Multi-pass membrane protein {ECO 0000269|PubMed 15774881}. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.2.3:the glycoside-pentoside-hexuronide (gph) cation symporter family # TIGRFAMs TIGR00792 gph # eggNOG COG2211 LUCA # eggNOG ENOG4105CT4 Bacteria BLAST swissprot:UIDB2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UIDB2_ECOLI DOI 10.1073/pnas.83.22.8447 http://dx.doi.org/10.1073/pnas.83.22.8447 DOI 10.1128/JB.187.7.2377-2385.2005 http://dx.doi.org/10.1128/JB.187.7.2377-2385.2005 EMBL M14641 http://www.ebi.ac.uk/ena/data/view/M14641 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015293 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293 GO_process GO:0006814 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814 GO_process GO:0008643 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008643 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 HOGENOM HOG000222021 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000222021&db=HOGENOM6 InterPro IPR001927 http://www.ebi.ac.uk/interpro/entry/IPR001927 InterPro IPR018043 http://www.ebi.ac.uk/interpro/entry/IPR018043 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 OMA AWISSIV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AWISSIV PROSITE PS00872 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00872 PSORT swissprot:UIDB2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UIDB2_ECOLI PSORT-B swissprot:UIDB2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UIDB2_ECOLI PSORT2 swissprot:UIDB2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UIDB2_ECOLI Phobius swissprot:UIDB2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UIDB2_ECOLI PhylomeDB P0CE45 http://phylomedb.org/?seqid=P0CE45 ProteinModelPortal P0CE45 http://www.proteinmodelportal.org/query/uniprot/P0CE45 PubMed 15774881 http://www.ncbi.nlm.nih.gov/pubmed/15774881 PubMed 3534890 http://www.ncbi.nlm.nih.gov/pubmed/3534890 STRING 511145.b1616 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1616&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.2.3 http://www.tcdb.org/search/result.php?tc=2.A.2.3 TIGRFAMs TIGR00792 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00792 UniProtKB UIDB2_ECOLI http://www.uniprot.org/uniprot/UIDB2_ECOLI UniProtKB-AC P0CE45 http://www.uniprot.org/uniprot/P0CE45 charge swissprot:UIDB2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UIDB2_ECOLI eggNOG COG2211 http://eggnogapi.embl.de/nog_data/html/tree/COG2211 eggNOG ENOG4105CT4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CT4 epestfind swissprot:UIDB2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UIDB2_ECOLI garnier swissprot:UIDB2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UIDB2_ECOLI helixturnhelix swissprot:UIDB2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UIDB2_ECOLI hmoment swissprot:UIDB2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UIDB2_ECOLI iep swissprot:UIDB2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UIDB2_ECOLI inforesidue swissprot:UIDB2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UIDB2_ECOLI octanol swissprot:UIDB2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UIDB2_ECOLI pepcoil swissprot:UIDB2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UIDB2_ECOLI pepdigest swissprot:UIDB2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UIDB2_ECOLI pepinfo swissprot:UIDB2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UIDB2_ECOLI pepnet swissprot:UIDB2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UIDB2_ECOLI pepstats swissprot:UIDB2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UIDB2_ECOLI pepwheel swissprot:UIDB2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UIDB2_ECOLI pepwindow swissprot:UIDB2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UIDB2_ECOLI sigcleave swissprot:UIDB2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UIDB2_ECOLI ## Database ID URL or Descriptions # AltName Lipid A acylation protein {ECO:0000255|HAMAP-Rule MF_00837} # BioGrid 4260645 351 # CATALYTIC ACTIVITY 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + lipid II(A) = 2-acyl-sn-glycero-3-phosphocholine + lipid II(B). {ECO:0000255|HAMAP-Rule MF_00837}. # CATALYTIC ACTIVITY PAGP_ECOLI 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A = 2-acyl-sn-glycero-3-phosphocholine + hepta- acyl lipid A. {ECO 0000255|HAMAP-Rule MF_00837, ECO 0000269|PubMed 11013210}. # CATALYTIC ACTIVITY PAGP_ECOLI 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IV(A) = 2-acyl-sn-glycero-3-phosphocholine + lipid IV(B). {ECO 0000255|HAMAP-Rule MF_00837, ECO 0000269|PubMed 11013210}. # ENZYME REGULATION Inhibited by lauryldimethylamine oxide (LDAO) and dodecylphosphocholine (DPC). {ECO:0000269|PubMed 15272304}. # EcoGene EG12180 pagP # FUNCTION PAGP_ECOLI Transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors. Phosphatidylglycerol (PtdGro), phosphatidylethanolamine (PtdEtn), phosphatidylserine (PtdSer) and phosphatidic acid (Ptd-OH) are all effective acyl donors. {ECO 0000269|PubMed 11013210, ECO 0000269|PubMed 20826347, ECO 0000269|PubMed 20853818}. # GO_component GO:0009279 cell outer membrane; IDA:UniProtKB. # GO_component GO:0016021 integral component of membrane; IEA:InterPro. # GO_function GO:0016416 O-palmitoyltransferase activity; IDA:UniProtKB. # GO_process GO:0009245 lipid A biosynthetic process; IDA:UniProtKB. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 2.40.160.20 -; 1. # HAMAP MF_00837 PagP_transferase # INDUCTION In magnesium-deficient conditions. {ECO:0000269|PubMed 9790526}. # InterPro IPR009746 Peptid-resist/lipidA_acyl_PagP # InterPro IPR011250 OMP/PagP_b-brl # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # KEGG_Pathway ko05133 Pertussis # MISCELLANEOUS Overproduction leads to camphor resistance and chromosome condensation. {ECO:0000269|PubMed 8844142}. # Organism PAGP_ECOLI Escherichia coli (strain K12) # PATRIC 32116424 VBIEscCol129921_0652 # PDB 1MM4 NMR; -; A=26-186 # PDB 1MM5 NMR; -; A=26-186 # PDB 1THQ X-ray; 1.90 A; A=26-186 # PDB 3GP6 X-ray; 1.40 A; A=26-186 # PIR D64796 D64796 # Pfam PF07017 PagP # ProDom PD103779 PagP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Lipid A palmitoyltransferase PagP {ECO:0000255|HAMAP-Rule MF_00837, ECO:0000305} # RefSeq NP_415155 NC_000913.3 # RefSeq WP_001103094 NZ_LN832404.1 # SIMILARITY Belongs to the lipid A palmitoyltransferase family. {ECO:0000255|HAMAP-Rule MF_00837, ECO:0000305}. # SUBCELLULAR LOCATION PAGP_ECOLI Cell outer membrane {ECO 0000255|HAMAP- Rule MF_00837, ECO 0000269|PubMed 11013210}. # SUBUNIT PAGP_ECOLI Homodimer. {ECO 0000255|HAMAP-Rule MF_00837, ECO 0000269|PubMed 11013210, ECO 0000269|PubMed 15272304, ECO 0000269|PubMed 20826347}. # SUPFAM SSF56925 SSF56925 # eggNOG ENOG41079UR Bacteria # eggNOG ENOG410XTHE LUCA BLAST swissprot:PAGP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PAGP_ECOLI BioCyc ECOL316407:JW0617-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0617-MONOMER BioCyc EcoCyc:EG12180-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12180-MONOMER BioCyc MetaCyc:EG12180-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12180-MONOMER DOI 10.1016/S0092-8674(00)81750-X http://dx.doi.org/10.1016/S0092-8674(00)81750-X DOI 10.1016/j.str.2010.06.014 http://dx.doi.org/10.1016/j.str.2010.06.014 DOI 10.1021/bi1011496 http://dx.doi.org/10.1021/bi1011496 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/sj.emboj.7600320 http://dx.doi.org/10.1038/sj.emboj.7600320 DOI 10.1073/pnas.212344499 http://dx.doi.org/10.1073/pnas.212344499 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/emboj/19.19.5071 http://dx.doi.org/10.1093/emboj/19.19.5071 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.251 {ECO:0000255|HAMAP-Rule:MF_00837, ECO:0000269|PubMed:11013210} http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.251 {ECO:0000255|HAMAP-Rule:MF_00837, ECO:0000269|PubMed:11013210} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D28497 http://www.ebi.ac.uk/ena/data/view/D28497 EMBL L29054 http://www.ebi.ac.uk/ena/data/view/L29054 EMBL S83396 http://www.ebi.ac.uk/ena/data/view/S83396 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 ENZYME 2.3.1.251 {ECO:0000255|HAMAP-Rule:MF_00837, ECO:0000269|PubMed:11013210} http://enzyme.expasy.org/EC/2.3.1.251 {ECO:0000255|HAMAP-Rule:MF_00837, ECO:0000269|PubMed:11013210} EchoBASE EB2097 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2097 EcoGene EG12180 http://www.ecogene.org/geneInfo.php?eg_id=EG12180 EnsemblBacteria AAC73723 http://www.ensemblgenomes.org/id/AAC73723 EnsemblBacteria AAC73723 http://www.ensemblgenomes.org/id/AAC73723 EnsemblBacteria BAA35265 http://www.ensemblgenomes.org/id/BAA35265 EnsemblBacteria BAA35265 http://www.ensemblgenomes.org/id/BAA35265 EnsemblBacteria BAA35265 http://www.ensemblgenomes.org/id/BAA35265 EnsemblBacteria b0622 http://www.ensemblgenomes.org/id/b0622 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0016416 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016416 GO_process GO:0009245 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009245 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 2.40.160.20 http://www.cathdb.info/version/latest/superfamily/2.40.160.20 GeneID 946360 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946360 HAMAP MF_00837 http://hamap.expasy.org/unirule/MF_00837 HOGENOM HOG000117945 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117945&db=HOGENOM6 IntEnz 2.3.1.251 {ECO:0000255|HAMAP-Rule:MF_00837, ECO:0000269|PubMed:11013210} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.251 {ECO:0000255|HAMAP-Rule:MF_00837, ECO:0000269|PubMed:11013210} InterPro IPR009746 http://www.ebi.ac.uk/interpro/entry/IPR009746 InterPro IPR011250 http://www.ebi.ac.uk/interpro/entry/IPR011250 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Gene ecj:JW0617 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0617 KEGG_Gene eco:b0622 http://www.genome.jp/dbget-bin/www_bget?eco:b0622 KEGG_Orthology KO:K12973 http://www.genome.jp/dbget-bin/www_bget?KO:K12973 KEGG_Pathway ko05133 http://www.genome.jp/kegg-bin/show_pathway?ko05133 OMA KTWRPLA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KTWRPLA PDB 1MM4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1MM4 PDB 1MM5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1MM5 PDB 1THQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1THQ PDB 3GP6 http://www.ebi.ac.uk/pdbe-srv/view/entry/3GP6 PDBsum 1MM4 http://www.ebi.ac.uk/pdbsum/1MM4 PDBsum 1MM5 http://www.ebi.ac.uk/pdbsum/1MM5 PDBsum 1THQ http://www.ebi.ac.uk/pdbsum/1THQ PDBsum 3GP6 http://www.ebi.ac.uk/pdbsum/3GP6 PSORT swissprot:PAGP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PAGP_ECOLI PSORT-B swissprot:PAGP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PAGP_ECOLI PSORT2 swissprot:PAGP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PAGP_ECOLI Pfam PF07017 http://pfam.xfam.org/family/PF07017 Phobius swissprot:PAGP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PAGP_ECOLI ProteinModelPortal P37001 http://www.proteinmodelportal.org/query/uniprot/P37001 PubMed 11013210 http://www.ncbi.nlm.nih.gov/pubmed/11013210 PubMed 12357033 http://www.ncbi.nlm.nih.gov/pubmed/12357033 PubMed 15272304 http://www.ncbi.nlm.nih.gov/pubmed/15272304 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20826347 http://www.ncbi.nlm.nih.gov/pubmed/20826347 PubMed 20853818 http://www.ncbi.nlm.nih.gov/pubmed/20853818 PubMed 8844142 http://www.ncbi.nlm.nih.gov/pubmed/8844142 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9790526 http://www.ncbi.nlm.nih.gov/pubmed/9790526 RefSeq NP_415155 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415155 RefSeq WP_001103094 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001103094 SMR P37001 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37001 STRING 511145.b0622 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0622&targetmode=cogs SUPFAM SSF56925 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56925 UniProtKB PAGP_ECOLI http://www.uniprot.org/uniprot/PAGP_ECOLI UniProtKB-AC P37001 http://www.uniprot.org/uniprot/P37001 charge swissprot:PAGP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PAGP_ECOLI eggNOG ENOG41079UR http://eggnogapi.embl.de/nog_data/html/tree/ENOG41079UR eggNOG ENOG410XTHE http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XTHE epestfind swissprot:PAGP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PAGP_ECOLI garnier swissprot:PAGP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PAGP_ECOLI helixturnhelix swissprot:PAGP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PAGP_ECOLI hmoment swissprot:PAGP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PAGP_ECOLI iep swissprot:PAGP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PAGP_ECOLI inforesidue swissprot:PAGP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PAGP_ECOLI octanol swissprot:PAGP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PAGP_ECOLI pepcoil swissprot:PAGP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PAGP_ECOLI pepdigest swissprot:PAGP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PAGP_ECOLI pepinfo swissprot:PAGP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PAGP_ECOLI pepnet swissprot:PAGP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PAGP_ECOLI pepstats swissprot:PAGP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PAGP_ECOLI pepwheel swissprot:PAGP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PAGP_ECOLI pepwindow swissprot:PAGP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PAGP_ECOLI sigcleave swissprot:PAGP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PAGP_ECOLI ## Database ID URL or Descriptions # BioGrid 4260155 258 # EcoGene EG13376 mppA # FUNCTION MPPA_ECOLI Essential for the uptake of the murein peptide L-alanyl- gamma-D-glutamyl-meso-diaminopimelate. Also transports some alpha- linked peptides such as Pro-Phe-Lys with low affinity. The transport is effected by the oligopeptide permease system. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_component GO:0042597 periplasmic space; IDA:EcoliWiki. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IEA:InterPro. # GO_function GO:0015197 peptide transporter activity; IBA:GO_Central. # GO_process GO:0015031 protein transport; IEA:UniProtKB-KW. # GO_process GO:0042939 tripeptide transport; IMP:EcoliWiki. # GO_process GO:0055085 transmembrane transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # InterPro IPR000914 SBP_5_dom # InterPro IPR023765 SBP_5_CS # InterPro IPR030678 Peptide/Ni-bd # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00439 Oligopeptide transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism MPPA_ECOLI Escherichia coli (strain K12) # PATRIC 32117934 VBIEscCol129921_1387 # PDB 3O9P X-ray; 2.07 A; A=23-537 # PDB 4TOZ X-ray; 1.50 A; A/B=23-537 # PIR D64882 D64882 # PIRSF PIRSF002741 MppA # PROSITE PS01040 SBP_BACTERIAL_5 # Pfam PF00496 SBP_bac_5 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MPPA_ECOLI Periplasmic murein peptide-binding protein # RefSeq NP_415845 NC_000913.3 # RefSeq WP_000683020 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial solute-binding protein 5 family. {ECO 0000305}. # SUBCELLULAR LOCATION MPPA_ECOLI Periplasm. # TCDB 3.A.1.5 the atp-binding cassette (abc) superfamily # TCDB 3.A.1.5.41 the atp-binding cassette (abc) superfamily # eggNOG COG4166 LUCA # eggNOG ENOG4107QSI Bacteria BLAST swissprot:MPPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MPPA_ECOLI BioCyc ECOL316407:JW1322-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1322-MONOMER BioCyc EcoCyc:G6665-MONOMER http://biocyc.org/getid?id=EcoCyc:G6665-MONOMER BioCyc MetaCyc:G6665-MONOMER http://biocyc.org/getid?id=MetaCyc:G6665-MONOMER COG COG4166 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4166 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U88242 http://www.ebi.ac.uk/ena/data/view/U88242 EchoBASE EB3158 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3158 EcoGene EG13376 http://www.ecogene.org/geneInfo.php?eg_id=EG13376 EnsemblBacteria AAC74411 http://www.ensemblgenomes.org/id/AAC74411 EnsemblBacteria AAC74411 http://www.ensemblgenomes.org/id/AAC74411 EnsemblBacteria BAA14922 http://www.ensemblgenomes.org/id/BAA14922 EnsemblBacteria BAA14922 http://www.ensemblgenomes.org/id/BAA14922 EnsemblBacteria BAA14922 http://www.ensemblgenomes.org/id/BAA14922 EnsemblBacteria b1329 http://www.ensemblgenomes.org/id/b1329 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0015197 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015197 GO_process GO:0015031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031 GO_process GO:0042939 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042939 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 945951 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945951 HOGENOM HOG000179191 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000179191&db=HOGENOM6 InParanoid P77348 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77348 InterPro IPR000914 http://www.ebi.ac.uk/interpro/entry/IPR000914 InterPro IPR023765 http://www.ebi.ac.uk/interpro/entry/IPR023765 InterPro IPR030678 http://www.ebi.ac.uk/interpro/entry/IPR030678 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1322 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1322 KEGG_Gene eco:b1329 http://www.genome.jp/dbget-bin/www_bget?eco:b1329 KEGG_Orthology KO:K15580 http://www.genome.jp/dbget-bin/www_bget?KO:K15580 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA IDRRVMA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IDRRVMA PDB 3O9P http://www.ebi.ac.uk/pdbe-srv/view/entry/3O9P PDB 4TOZ http://www.ebi.ac.uk/pdbe-srv/view/entry/4TOZ PDBsum 3O9P http://www.ebi.ac.uk/pdbsum/3O9P PDBsum 4TOZ http://www.ebi.ac.uk/pdbsum/4TOZ PROSITE PS01040 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01040 PSORT swissprot:MPPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MPPA_ECOLI PSORT-B swissprot:MPPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MPPA_ECOLI PSORT2 swissprot:MPPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MPPA_ECOLI Pfam PF00496 http://pfam.xfam.org/family/PF00496 Phobius swissprot:MPPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MPPA_ECOLI PhylomeDB P77348 http://phylomedb.org/?seqid=P77348 ProteinModelPortal P77348 http://www.proteinmodelportal.org/query/uniprot/P77348 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9495761 http://www.ncbi.nlm.nih.gov/pubmed/9495761 RefSeq NP_415845 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415845 RefSeq WP_000683020 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000683020 SMR P77348 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77348 STRING 511145.b1329 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1329&targetmode=cogs STRING COG4166 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4166&targetmode=cogs SWISS-2DPAGE P77348 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P77348 TCDB 3.A.1.5 http://www.tcdb.org/search/result.php?tc=3.A.1.5 TCDB 3.A.1.5.41 http://www.tcdb.org/search/result.php?tc=3.A.1.5.41 UniProtKB MPPA_ECOLI http://www.uniprot.org/uniprot/MPPA_ECOLI UniProtKB-AC P77348 http://www.uniprot.org/uniprot/P77348 charge swissprot:MPPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MPPA_ECOLI eggNOG COG4166 http://eggnogapi.embl.de/nog_data/html/tree/COG4166 eggNOG ENOG4107QSI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QSI epestfind swissprot:MPPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MPPA_ECOLI garnier swissprot:MPPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MPPA_ECOLI helixturnhelix swissprot:MPPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MPPA_ECOLI hmoment swissprot:MPPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MPPA_ECOLI iep swissprot:MPPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MPPA_ECOLI inforesidue swissprot:MPPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MPPA_ECOLI octanol swissprot:MPPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MPPA_ECOLI pepcoil swissprot:MPPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MPPA_ECOLI pepdigest swissprot:MPPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MPPA_ECOLI pepinfo swissprot:MPPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MPPA_ECOLI pepnet swissprot:MPPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MPPA_ECOLI pepstats swissprot:MPPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MPPA_ECOLI pepwheel swissprot:MPPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MPPA_ECOLI pepwindow swissprot:MPPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MPPA_ECOLI sigcleave swissprot:MPPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MPPA_ECOLI ## Database ID URL or Descriptions # AltName MALT_ECOLI ATP-dependent transcriptional activator MalT # BioGrid 4261189 19 # CDD cd06170 LuxR_C_like # DOMAIN MALT_ECOLI Consists of four structural domains the ATP binding site resides in domain I (DT1); DT3 binds the positive effector maltotriose with a low affinity, and the binding affinity is increased in the presence of DT2; the C-terminal domain DT4 contains the helix-turn-helix DNA binding motif. DT1 also contains the region that interacts with MalY (but not with MalK), and the binding site for aes is also likely to be contained in the N- terminal portion of MalT encompassing DT1 and DT2. {ECO 0000269|PubMed 12003949}. # DrugBank DB03793 Benzoic Acid # EcoGene EG10562 malT # FUNCTION MALT_ECOLI Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Binds and recognizes a DNA motif (called the malT box) 5'-GGA[TG]GA-3'. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0048031 trisaccharide binding; IMP:EcoCyc. # GO_process GO:0005975 carbohydrate metabolic process; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-HAMAP. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IEA:UniProtKB-HAMAP. # GO_process GO:0045913 positive regulation of carbohydrate metabolic process; IEA:UniProtKB-HAMAP. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # Gene3D 1.25.40.10 -; 1. # Gene3D 3.40.50.300 -; 1. # HAMAP MF_01247 HTH_type_MalT # INTERACTION MALT_ECOLI Self; NbExp=2; IntAct=EBI-542934, EBI-542934; P08622 dnaJ; NbExp=3; IntAct=EBI-542934, EBI-545285; P0ACG8 hslR; NbExp=2; IntAct=EBI-542934, EBI-562824; # IntAct P06993 29 # InterPro IPR000792 Tscrpt_reg_LuxR_C # InterPro IPR011990 TPR-like_helical_dom # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR016032 Sig_transdc_resp-reg_C-effctor # InterPro IPR023768 Tscrpt_reg_HTH_MalT # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko03000 Transcription factors # MISCELLANEOUS A study on malT mutants (PubMed:12003949) has shown that some of them became nearly completely resistant to Aes repression while still being sensitive to MalY. These mutations are located at positions 38, 220, 243, and 359, most likely defining the interaction patch with aes on the three-dimensional structure of MalT. {ECO 0000305|PubMed:12003949}. # Organism MALT_ECOLI Escherichia coli (strain K12) # PATRIC 32122274 VBIEscCol129921_3514 # PDB 1HZ4 X-ray; 1.45 A; A=437-806 # PIR E65137 RGECMT # PRINTS PR00038 HTHLUXR # PROSITE PS00622 HTH_LUXR_1 # PROSITE PS50043 HTH_LUXR_2 # Pfam PF00196 GerE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MALT_ECOLI HTH-type transcriptional regulator MalT # RefSeq NP_417877 NC_000913.3 # RefSeq WP_000906961 NZ_CP014272.1 # SIMILARITY Contains 1 HTH luxR-type DNA-binding domain. {ECO 0000305}. # SMART SM00421 HTH_LUXR # SUBUNIT MALT_ECOLI Monomer in solution but oligomerizes to an active state in the presence of the positive effectors ATP and maltotriose. Interacts with MalY, MalK and Aes, all of which negatively regulate MalT activity by antagonizing maltotriose binding. # SUPFAM SSF46894 SSF46894 # SUPFAM SSF48452 SSF48452 # SUPFAM SSF52540 SSF52540 # eggNOG COG2909 LUCA # eggNOG ENOG41061ZR Bacteria BLAST swissprot:MALT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MALT_ECOLI BioCyc ECOL316407:JW3381-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3381-MONOMER BioCyc EcoCyc:PD00237 http://biocyc.org/getid?id=EcoCyc:PD00237 BioCyc MetaCyc:PD00237 http://biocyc.org/getid?id=MetaCyc:PD00237 COG COG2909 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2909 DIP DIP-10149N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10149N DOI 10.1007/BF00333795 http://dx.doi.org/10.1007/BF00333795 DOI 10.1016/0378-1119(86)90297-0 http://dx.doi.org/10.1016/0378-1119(86)90297-0 DOI 10.1016/S0969-2126(01)00665-7 http://dx.doi.org/10.1016/S0969-2126(01)00665-7 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.11.3069-3077.2002 http://dx.doi.org/10.1128/JB.184.11.3069-3077.2002 DrugBank DB03793 http://www.drugbank.ca/drugs/DB03793 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M13585 http://www.ebi.ac.uk/ena/data/view/M13585 EMBL M24342 http://www.ebi.ac.uk/ena/data/view/M24342 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL V00304 http://www.ebi.ac.uk/ena/data/view/V00304 EMBL X02003 http://www.ebi.ac.uk/ena/data/view/X02003 EchoBASE EB0557 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0557 EcoGene EG10562 http://www.ecogene.org/geneInfo.php?eg_id=EG10562 EnsemblBacteria AAC76443 http://www.ensemblgenomes.org/id/AAC76443 EnsemblBacteria AAC76443 http://www.ensemblgenomes.org/id/AAC76443 EnsemblBacteria BAE77873 http://www.ensemblgenomes.org/id/BAE77873 EnsemblBacteria BAE77873 http://www.ensemblgenomes.org/id/BAE77873 EnsemblBacteria BAE77873 http://www.ensemblgenomes.org/id/BAE77873 EnsemblBacteria b3418 http://www.ensemblgenomes.org/id/b3418 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0048031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048031 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GO_process GO:0045913 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045913 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 1.25.40.10 http://www.cathdb.info/version/latest/superfamily/1.25.40.10 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947921 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947921 HAMAP MF_01247 http://hamap.expasy.org/unirule/MF_01247 HOGENOM HOG000218261 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218261&db=HOGENOM6 InParanoid P06993 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P06993 IntAct P06993 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P06993* InterPro IPR000792 http://www.ebi.ac.uk/interpro/entry/IPR000792 InterPro IPR011990 http://www.ebi.ac.uk/interpro/entry/IPR011990 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR016032 http://www.ebi.ac.uk/interpro/entry/IPR016032 InterPro IPR023768 http://www.ebi.ac.uk/interpro/entry/IPR023768 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW3381 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3381 KEGG_Gene eco:b3418 http://www.genome.jp/dbget-bin/www_bget?eco:b3418 KEGG_Orthology KO:K03556 http://www.genome.jp/dbget-bin/www_bget?KO:K03556 MINT MINT-1233939 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1233939 OMA SDWVSNA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SDWVSNA PDB 1HZ4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1HZ4 PDBsum 1HZ4 http://www.ebi.ac.uk/pdbsum/1HZ4 PRINTS PR00038 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00038 PROSITE PS00622 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00622 PROSITE PS50043 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50043 PSORT swissprot:MALT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MALT_ECOLI PSORT-B swissprot:MALT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MALT_ECOLI PSORT2 swissprot:MALT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MALT_ECOLI Pfam PF00196 http://pfam.xfam.org/family/PF00196 Phobius swissprot:MALT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MALT_ECOLI PhylomeDB P06993 http://phylomedb.org/?seqid=P06993 ProteinModelPortal P06993 http://www.proteinmodelportal.org/query/uniprot/P06993 PubMed 11709169 http://www.ncbi.nlm.nih.gov/pubmed/11709169 PubMed 12003949 http://www.ncbi.nlm.nih.gov/pubmed/12003949 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2524384 http://www.ncbi.nlm.nih.gov/pubmed/2524384 PubMed 3015733 http://www.ncbi.nlm.nih.gov/pubmed/3015733 PubMed 6283313 http://www.ncbi.nlm.nih.gov/pubmed/6283313 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417877 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417877 RefSeq WP_000906961 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000906961 SMART SM00421 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00421 SMR P06993 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P06993 STRING 511145.b3418 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3418&targetmode=cogs STRING COG2909 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2909&targetmode=cogs SUPFAM SSF46894 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46894 SUPFAM SSF48452 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48452 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB MALT_ECOLI http://www.uniprot.org/uniprot/MALT_ECOLI UniProtKB-AC P06993 http://www.uniprot.org/uniprot/P06993 charge swissprot:MALT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MALT_ECOLI eggNOG COG2909 http://eggnogapi.embl.de/nog_data/html/tree/COG2909 eggNOG ENOG41061ZR http://eggnogapi.embl.de/nog_data/html/tree/ENOG41061ZR epestfind swissprot:MALT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MALT_ECOLI garnier swissprot:MALT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MALT_ECOLI helixturnhelix swissprot:MALT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MALT_ECOLI hmoment swissprot:MALT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MALT_ECOLI iep swissprot:MALT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MALT_ECOLI inforesidue swissprot:MALT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MALT_ECOLI octanol swissprot:MALT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MALT_ECOLI pepcoil swissprot:MALT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MALT_ECOLI pepdigest swissprot:MALT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MALT_ECOLI pepinfo swissprot:MALT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MALT_ECOLI pepnet swissprot:MALT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MALT_ECOLI pepstats swissprot:MALT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MALT_ECOLI pepwheel swissprot:MALT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MALT_ECOLI pepwindow swissprot:MALT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MALT_ECOLI sigcleave swissprot:MALT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MALT_ECOLI ## Database ID URL or Descriptions # BioGrid 4262491 27 # CDD cd08489 PBP2_NikA # EcoGene EG12075 nikA # FUNCTION NIKA_ECOLI Involved in a nickel transport system, probably represents the nickel binder. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_component GO:0042597 periplasmic space; IDA:EcoliWiki. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IEA:InterPro. # GO_function GO:0015197 peptide transporter activity; IBA:GO_Central. # GO_function GO:0016151 nickel cation binding; IDA:EcoliWiki. # GO_function GO:0020037 heme binding; IDA:EcoliWiki. # GO_function GO:0046914 transition metal ion binding; IDA:EcoliWiki. # GO_process GO:0015675 nickel cation transport; IEA:InterPro. # GO_process GO:0050919 negative chemotaxis; IMP:EcoliWiki. # GO_process GO:0055085 transmembrane transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # GOslim_process GO:0040011 locomotion # GOslim_process GO:0055085 transmembrane transport # InterPro IPR000914 SBP_5_dom # InterPro IPR011980 NikA_ABC_Ni-bd # InterPro IPR023765 SBP_5_CS # InterPro IPR030678 Peptide/Ni-bd # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00440 Nickel transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism NIKA_ECOLI Escherichia coli (strain K12) # PATRIC 32122396 VBIEscCol129921_3575 # PDB 1UIU X-ray; 1.85 A; A/B=23-524 # PDB 1UIV X-ray; 1.95 A; A/B=23-524 # PDB 1ZLQ X-ray; 1.80 A; A/B=23-524 # PDB 2NOO X-ray; 1.65 A; A=23-524 # PDB 3DP8 X-ray; 2.50 A; A/B/C=23-524 # PDB 3E3K X-ray; 2.80 A; A/B/C=23-524 # PDB 3MVW X-ray; 1.79 A; A/B=23-524 # PDB 3MVX X-ray; 1.70 A; A/B=23-524 # PDB 3MVY X-ray; 2.50 A; A/B=23-524 # PDB 3MVZ X-ray; 1.70 A; A/B=23-524 # PDB 3MW0 X-ray; 2.30 A; A/B=23-524 # PDB 3MZ9 X-ray; 1.80 A; A/B=23-524 # PDB 3MZB X-ray; 1.70 A; A/B=23-523 # PDB 3QIM X-ray; 2.10 A; A/B=23-524 # PDB 4DCX X-ray; 2.00 A; A/B=23-524 # PDB 4DCY X-ray; 2.00 A; A/B=23-524 # PDB 4I8C X-ray; 2.50 A; A/B/C=23-524 # PDB 4I9D X-ray; 1.70 A; A/B=23-524 # PIR S39594 S39594 # PIRSF PIRSF002741 MppA # PROSITE PS01040 SBP_BACTERIAL_5 # Pfam PF00496 SBP_bac_5 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NIKA_ECOLI Nickel-binding periplasmic protein # RefSeq NP_417933 NC_000913.3 # RefSeq WP_000953361 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial solute-binding protein 5 family. {ECO 0000305}. # SUBCELLULAR LOCATION NIKA_ECOLI Periplasm {ECO 0000305}. # TCDB 3.A.1.5 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR02294 nickel_nikA # eggNOG COG0747 LUCA # eggNOG ENOG4107RNA Bacteria BLAST swissprot:NIKA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NIKA_ECOLI BioCyc ECOL316407:JW3441-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3441-MONOMER BioCyc EcoCyc:NIKA-MONOMER http://biocyc.org/getid?id=EcoCyc:NIKA-MONOMER BioCyc MetaCyc:NIKA-MONOMER http://biocyc.org/getid?id=MetaCyc:NIKA-MONOMER COG COG0747 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0747 DIP DIP-10340N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10340N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M307941200 http://dx.doi.org/10.1074/jbc.M307941200 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1111/j.1365-2958.1993.tb01247.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb01247.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X73143 http://www.ebi.ac.uk/ena/data/view/X73143 EchoBASE EB2000 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2000 EcoGene EG12075 http://www.ecogene.org/geneInfo.php?eg_id=EG12075 EnsemblBacteria AAC76501 http://www.ensemblgenomes.org/id/AAC76501 EnsemblBacteria AAC76501 http://www.ensemblgenomes.org/id/AAC76501 EnsemblBacteria BAE77817 http://www.ensemblgenomes.org/id/BAE77817 EnsemblBacteria BAE77817 http://www.ensemblgenomes.org/id/BAE77817 EnsemblBacteria BAE77817 http://www.ensemblgenomes.org/id/BAE77817 EnsemblBacteria b3476 http://www.ensemblgenomes.org/id/b3476 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0015197 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015197 GO_function GO:0016151 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016151 GO_function GO:0020037 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0020037 GO_function GO:0046914 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046914 GO_process GO:0015675 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015675 GO_process GO:0050919 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050919 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0040011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 947981 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947981 HOGENOM HOG000125740 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125740&db=HOGENOM6 InParanoid P33590 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33590 IntAct P33590 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33590* InterPro IPR000914 http://www.ebi.ac.uk/interpro/entry/IPR000914 InterPro IPR011980 http://www.ebi.ac.uk/interpro/entry/IPR011980 InterPro IPR023765 http://www.ebi.ac.uk/interpro/entry/IPR023765 InterPro IPR030678 http://www.ebi.ac.uk/interpro/entry/IPR030678 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3441 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3441 KEGG_Gene eco:b3476 http://www.genome.jp/dbget-bin/www_bget?eco:b3476 KEGG_Orthology KO:K15584 http://www.genome.jp/dbget-bin/www_bget?KO:K15584 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 MINT MINT-1272849 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1272849 OMA FTRHEGY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FTRHEGY PDB 1UIU http://www.ebi.ac.uk/pdbe-srv/view/entry/1UIU PDB 1UIV http://www.ebi.ac.uk/pdbe-srv/view/entry/1UIV PDB 1ZLQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZLQ PDB 2NOO http://www.ebi.ac.uk/pdbe-srv/view/entry/2NOO PDB 3DP8 http://www.ebi.ac.uk/pdbe-srv/view/entry/3DP8 PDB 3E3K http://www.ebi.ac.uk/pdbe-srv/view/entry/3E3K PDB 3MVW http://www.ebi.ac.uk/pdbe-srv/view/entry/3MVW PDB 3MVX http://www.ebi.ac.uk/pdbe-srv/view/entry/3MVX PDB 3MVY http://www.ebi.ac.uk/pdbe-srv/view/entry/3MVY PDB 3MVZ http://www.ebi.ac.uk/pdbe-srv/view/entry/3MVZ PDB 3MW0 http://www.ebi.ac.uk/pdbe-srv/view/entry/3MW0 PDB 3MZ9 http://www.ebi.ac.uk/pdbe-srv/view/entry/3MZ9 PDB 3MZB http://www.ebi.ac.uk/pdbe-srv/view/entry/3MZB PDB 3QIM http://www.ebi.ac.uk/pdbe-srv/view/entry/3QIM PDB 4DCX http://www.ebi.ac.uk/pdbe-srv/view/entry/4DCX PDB 4DCY http://www.ebi.ac.uk/pdbe-srv/view/entry/4DCY PDB 4I8C http://www.ebi.ac.uk/pdbe-srv/view/entry/4I8C PDB 4I9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4I9D PDBsum 1UIU http://www.ebi.ac.uk/pdbsum/1UIU PDBsum 1UIV http://www.ebi.ac.uk/pdbsum/1UIV PDBsum 1ZLQ http://www.ebi.ac.uk/pdbsum/1ZLQ PDBsum 2NOO http://www.ebi.ac.uk/pdbsum/2NOO PDBsum 3DP8 http://www.ebi.ac.uk/pdbsum/3DP8 PDBsum 3E3K http://www.ebi.ac.uk/pdbsum/3E3K PDBsum 3MVW http://www.ebi.ac.uk/pdbsum/3MVW PDBsum 3MVX http://www.ebi.ac.uk/pdbsum/3MVX PDBsum 3MVY http://www.ebi.ac.uk/pdbsum/3MVY PDBsum 3MVZ http://www.ebi.ac.uk/pdbsum/3MVZ PDBsum 3MW0 http://www.ebi.ac.uk/pdbsum/3MW0 PDBsum 3MZ9 http://www.ebi.ac.uk/pdbsum/3MZ9 PDBsum 3MZB http://www.ebi.ac.uk/pdbsum/3MZB PDBsum 3QIM http://www.ebi.ac.uk/pdbsum/3QIM PDBsum 4DCX http://www.ebi.ac.uk/pdbsum/4DCX PDBsum 4DCY http://www.ebi.ac.uk/pdbsum/4DCY PDBsum 4I8C http://www.ebi.ac.uk/pdbsum/4I8C PDBsum 4I9D http://www.ebi.ac.uk/pdbsum/4I9D PROSITE PS01040 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01040 PSORT swissprot:NIKA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NIKA_ECOLI PSORT-B swissprot:NIKA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NIKA_ECOLI PSORT2 swissprot:NIKA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NIKA_ECOLI Pfam PF00496 http://pfam.xfam.org/family/PF00496 Phobius swissprot:NIKA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NIKA_ECOLI PhylomeDB P33590 http://phylomedb.org/?seqid=P33590 ProteinModelPortal P33590 http://www.proteinmodelportal.org/query/uniprot/P33590 PubMed 12960164 http://www.ncbi.nlm.nih.gov/pubmed/12960164 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7934931 http://www.ncbi.nlm.nih.gov/pubmed/7934931 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417933 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417933 RefSeq WP_000953361 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000953361 SMR P33590 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33590 STRING 511145.b3476 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3476&targetmode=cogs STRING COG0747 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0747&targetmode=cogs TCDB 3.A.1.5 http://www.tcdb.org/search/result.php?tc=3.A.1.5 TIGRFAMs TIGR02294 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02294 UniProtKB NIKA_ECOLI http://www.uniprot.org/uniprot/NIKA_ECOLI UniProtKB-AC P33590 http://www.uniprot.org/uniprot/P33590 charge swissprot:NIKA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NIKA_ECOLI eggNOG COG0747 http://eggnogapi.embl.de/nog_data/html/tree/COG0747 eggNOG ENOG4107RNA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107RNA epestfind swissprot:NIKA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NIKA_ECOLI garnier swissprot:NIKA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NIKA_ECOLI helixturnhelix swissprot:NIKA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NIKA_ECOLI hmoment swissprot:NIKA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NIKA_ECOLI iep swissprot:NIKA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NIKA_ECOLI inforesidue swissprot:NIKA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NIKA_ECOLI octanol swissprot:NIKA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NIKA_ECOLI pepcoil swissprot:NIKA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NIKA_ECOLI pepdigest swissprot:NIKA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NIKA_ECOLI pepinfo swissprot:NIKA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NIKA_ECOLI pepnet swissprot:NIKA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NIKA_ECOLI pepstats swissprot:NIKA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NIKA_ECOLI pepwheel swissprot:NIKA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NIKA_ECOLI pepwindow swissprot:NIKA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NIKA_ECOLI sigcleave swissprot:NIKA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NIKA_ECOLI ## Database ID URL or Descriptions # AltName YJJA_ECOLI Protein P-18 # BioGrid 4261868 388 # EcoGene EG11214 yjjA # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # InterPro IPR019637 DUF2501 # Organism YJJA_ECOLI Escherichia coli (strain K12) # PATRIC 32124328 VBIEscCol129921_4507 # PIR S56587 RMEC18 # Pfam PF10696 DUF2501 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJJA_ECOLI Uncharacterized protein YjjA # RefSeq NP_418780 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA23701.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAA97259.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # eggNOG ENOG4105RI1 Bacteria # eggNOG ENOG4111ZVK LUCA BLAST swissprot:YJJA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJJA_ECOLI BioCyc ECOL316407:JW5795-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5795-MONOMER BioCyc EcoCyc:EG11214-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11214-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J04030 http://www.ebi.ac.uk/ena/data/view/J04030 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB1198 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1198 EcoGene EG11214 http://www.ecogene.org/geneInfo.php?eg_id=EG11214 EnsemblBacteria AAC77316 http://www.ensemblgenomes.org/id/AAC77316 EnsemblBacteria AAC77316 http://www.ensemblgenomes.org/id/AAC77316 EnsemblBacteria BAE78350 http://www.ensemblgenomes.org/id/BAE78350 EnsemblBacteria BAE78350 http://www.ensemblgenomes.org/id/BAE78350 EnsemblBacteria BAE78350 http://www.ensemblgenomes.org/id/BAE78350 EnsemblBacteria b4360 http://www.ensemblgenomes.org/id/b4360 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GeneID 948887 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948887 HOGENOM HOG000127584 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000127584&db=HOGENOM6 InterPro IPR019637 http://www.ebi.ac.uk/interpro/entry/IPR019637 KEGG_Gene ecj:JW5795 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5795 KEGG_Gene eco:b4360 http://www.genome.jp/dbget-bin/www_bget?eco:b4360 OMA WQDSLSS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WQDSLSS PSORT swissprot:YJJA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJJA_ECOLI PSORT-B swissprot:YJJA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJJA_ECOLI PSORT2 swissprot:YJJA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJJA_ECOLI Pfam PF10696 http://pfam.xfam.org/family/PF10696 Phobius swissprot:YJJA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJJA_ECOLI ProteinModelPortal P18390 http://www.proteinmodelportal.org/query/uniprot/P18390 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2844800 http://www.ncbi.nlm.nih.gov/pubmed/2844800 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418780 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418780 STRING 511145.b4360 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4360&targetmode=cogs UniProtKB YJJA_ECOLI http://www.uniprot.org/uniprot/YJJA_ECOLI UniProtKB-AC P18390 http://www.uniprot.org/uniprot/P18390 charge swissprot:YJJA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJJA_ECOLI eggNOG ENOG4105RI1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105RI1 eggNOG ENOG4111ZVK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111ZVK epestfind swissprot:YJJA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJJA_ECOLI garnier swissprot:YJJA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJJA_ECOLI helixturnhelix swissprot:YJJA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJJA_ECOLI hmoment swissprot:YJJA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJJA_ECOLI iep swissprot:YJJA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJJA_ECOLI inforesidue swissprot:YJJA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJJA_ECOLI octanol swissprot:YJJA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJJA_ECOLI pepcoil swissprot:YJJA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJJA_ECOLI pepdigest swissprot:YJJA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJJA_ECOLI pepinfo swissprot:YJJA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJJA_ECOLI pepnet swissprot:YJJA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJJA_ECOLI pepstats swissprot:YJJA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJJA_ECOLI pepwheel swissprot:YJJA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJJA_ECOLI pepwindow swissprot:YJJA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJJA_ECOLI sigcleave swissprot:YJJA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJJA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262323 12 # CDD cd05649 M20_ArgE_DapE_like4 # COFACTOR YGEY_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000250}; Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000250}; Note=Binds 2 Zn(2+) or Co(2+) ions per subunit. {ECO 0000250}; # EcoGene EG13055 ygeY # GO_function GO:0008270 zinc ion binding; IBA:GO_Central. # GO_function GO:0070573 metallodipeptidase activity; IBA:GO_Central. # GO_process GO:0043171 peptide catabolic process; IBA:GO_Central. # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.30.70.360 -; 1. # IntAct P65807 10 # InterPro IPR001261 ArgE/DapE_CS # InterPro IPR002933 Peptidase_M20 # InterPro IPR011650 Peptidase_M20_dimer # InterPro IPR017706 Peptidase_M20/DapE_YgeY # Organism YGEY_ECOLI Escherichia coli (strain K12) # PATRIC 32121154 VBIEscCol129921_2965 # PIR H65070 H65070 # PROSITE PS00758 ARGE_DAPE_CPG2_1 # Pfam PF01546 Peptidase_M20 # Pfam PF07687 M20_dimer # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGEY_ECOLI Uncharacterized protein YgeY # RefSeq NP_417348 NC_000913.3 # RefSeq WP_001107125 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase M20A family. {ECO 0000305}. # SUPFAM SSF55031 SSF55031 # TIGRFAMs TIGR03526 selenium_YgeY # eggNOG COG0624 LUCA # eggNOG ENOG4107S4Y Bacteria BLAST swissprot:YGEY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGEY_ECOLI BioCyc ECOL316407:JW2840-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2840-MONOMER BioCyc EcoCyc:G7491-MONOMER http://biocyc.org/getid?id=EcoCyc:G7491-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 EchoBASE EB2867 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2867 EcoGene EG13055 http://www.ecogene.org/geneInfo.php?eg_id=EG13055 EnsemblBacteria AAC75910 http://www.ensemblgenomes.org/id/AAC75910 EnsemblBacteria AAC75910 http://www.ensemblgenomes.org/id/AAC75910 EnsemblBacteria BAE76938 http://www.ensemblgenomes.org/id/BAE76938 EnsemblBacteria BAE76938 http://www.ensemblgenomes.org/id/BAE76938 EnsemblBacteria BAE76938 http://www.ensemblgenomes.org/id/BAE76938 EnsemblBacteria b2872 http://www.ensemblgenomes.org/id/b2872 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0070573 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070573 GO_process GO:0043171 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043171 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.30.70.360 http://www.cathdb.info/version/latest/superfamily/3.30.70.360 GeneID 947360 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947360 HOGENOM HOG000243776 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000243776&db=HOGENOM6 InParanoid P65807 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P65807 IntAct P65807 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P65807* InterPro IPR001261 http://www.ebi.ac.uk/interpro/entry/IPR001261 InterPro IPR002933 http://www.ebi.ac.uk/interpro/entry/IPR002933 InterPro IPR011650 http://www.ebi.ac.uk/interpro/entry/IPR011650 InterPro IPR017706 http://www.ebi.ac.uk/interpro/entry/IPR017706 KEGG_Gene ecj:JW2840 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2840 KEGG_Gene eco:b2872 http://www.genome.jp/dbget-bin/www_bget?eco:b2872 OMA NAIYKMA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NAIYKMA PROSITE PS00758 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00758 PSORT swissprot:YGEY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGEY_ECOLI PSORT-B swissprot:YGEY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGEY_ECOLI PSORT2 swissprot:YGEY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGEY_ECOLI Pfam PF01546 http://pfam.xfam.org/family/PF01546 Pfam PF07687 http://pfam.xfam.org/family/PF07687 Phobius swissprot:YGEY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGEY_ECOLI PhylomeDB P65807 http://phylomedb.org/?seqid=P65807 ProteinModelPortal P65807 http://www.proteinmodelportal.org/query/uniprot/P65807 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417348 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417348 RefSeq WP_001107125 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001107125 STRING 511145.b2872 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2872&targetmode=cogs SUPFAM SSF55031 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55031 TIGRFAMs TIGR03526 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03526 UniProtKB YGEY_ECOLI http://www.uniprot.org/uniprot/YGEY_ECOLI UniProtKB-AC P65807 http://www.uniprot.org/uniprot/P65807 charge swissprot:YGEY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGEY_ECOLI eggNOG COG0624 http://eggnogapi.embl.de/nog_data/html/tree/COG0624 eggNOG ENOG4107S4Y http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107S4Y epestfind swissprot:YGEY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGEY_ECOLI garnier swissprot:YGEY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGEY_ECOLI helixturnhelix swissprot:YGEY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGEY_ECOLI hmoment swissprot:YGEY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGEY_ECOLI iep swissprot:YGEY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGEY_ECOLI inforesidue swissprot:YGEY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGEY_ECOLI octanol swissprot:YGEY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGEY_ECOLI pepcoil swissprot:YGEY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGEY_ECOLI pepdigest swissprot:YGEY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGEY_ECOLI pepinfo swissprot:YGEY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGEY_ECOLI pepnet swissprot:YGEY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGEY_ECOLI pepstats swissprot:YGEY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGEY_ECOLI pepwheel swissprot:YGEY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGEY_ECOLI pepwindow swissprot:YGEY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGEY_ECOLI sigcleave swissprot:YGEY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGEY_ECOLI ## Database ID URL or Descriptions # BioGrid 4262816 50 # EcoGene EG10765 priC # FUNCTION PRIC_ECOLI PriA recognizes a specific hairpin sequence on bacteriophage phi X174 ssDNA. This structure is then recognized and bound by proteins PriB and PriC. Formation of the primosome proceeds with the subsequent actions of DnaB, DnaC, DnaT and primase. # GO_component GO:1990077 primosome complex; IEA:UniProtKB-KW. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_process GO:0006261 DNA-dependent DNA replication; IMP:EcoCyc. # GO_process GO:0006269 DNA replication, synthesis of RNA primer; IEA:UniProtKB-KW. # GO_process GO:0006270 DNA replication initiation; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0009058 biosynthetic process # INTERACTION PRIC_ECOLI P0ACJ8 crp; NbExp=2; IntAct=EBI-1117383, EBI-547513; P0ACB0 dnaB; NbExp=5; IntAct=EBI-1117383, EBI-548978; P77732 rhmR; NbExp=3; IntAct=EBI-1117383, EBI-549004; # IntAct P23862 25 # InterPro IPR010890 Primosomal_replicat_PriB/PriC # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko03440 Homologous recombination # Organism PRIC_ECOLI Escherichia coli (strain K12) # PATRIC 32116089 VBIEscCol129921_0486 # PDB 2RT6 NMR; -; A=1-98 # PIR JQ1149 JQ1149 # Pfam PF07445 PriC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PRIC_ECOLI Primosomal replication protein N'' # RefSeq NP_415000 NC_000913.3 # RefSeq WP_000844874 NZ_LN832404.1 # eggNOG COG3923 LUCA # eggNOG ENOG4108URS Bacteria BLAST swissprot:PRIC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PRIC_ECOLI BioCyc ECOL316407:JW0456-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0456-MONOMER BioCyc EcoCyc:EG10765-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10765-MONOMER BioCyc MetaCyc:EG10765-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10765-MONOMER COG COG3923 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3923 DIP DIP-10564N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10564N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D13958 http://www.ebi.ac.uk/ena/data/view/D13958 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EchoBASE EB0758 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0758 EcoGene EG10765 http://www.ecogene.org/geneInfo.php?eg_id=EG10765 EnsemblBacteria AAC73569 http://www.ensemblgenomes.org/id/AAC73569 EnsemblBacteria AAC73569 http://www.ensemblgenomes.org/id/AAC73569 EnsemblBacteria BAE76246 http://www.ensemblgenomes.org/id/BAE76246 EnsemblBacteria BAE76246 http://www.ensemblgenomes.org/id/BAE76246 EnsemblBacteria BAE76246 http://www.ensemblgenomes.org/id/BAE76246 EnsemblBacteria b0467 http://www.ensemblgenomes.org/id/b0467 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:1990077 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990077 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006261 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006261 GO_process GO:0006269 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006269 GO_process GO:0006270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006270 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 945071 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945071 HOGENOM HOG000117643 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117643&db=HOGENOM6 IntAct P23862 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P23862* InterPro IPR010890 http://www.ebi.ac.uk/interpro/entry/IPR010890 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW0456 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0456 KEGG_Gene eco:b0467 http://www.genome.jp/dbget-bin/www_bget?eco:b0467 KEGG_Orthology KO:K04067 http://www.genome.jp/dbget-bin/www_bget?KO:K04067 KEGG_Pathway ko03440 http://www.genome.jp/kegg-bin/show_pathway?ko03440 OMA QHQEYER http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QHQEYER PDB 2RT6 http://www.ebi.ac.uk/pdbe-srv/view/entry/2RT6 PDBsum 2RT6 http://www.ebi.ac.uk/pdbsum/2RT6 PSORT swissprot:PRIC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PRIC_ECOLI PSORT-B swissprot:PRIC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PRIC_ECOLI PSORT2 swissprot:PRIC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PRIC_ECOLI Pfam PF07445 http://pfam.xfam.org/family/PF07445 Phobius swissprot:PRIC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PRIC_ECOLI ProteinModelPortal P23862 http://www.proteinmodelportal.org/query/uniprot/P23862 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1856227 http://www.ncbi.nlm.nih.gov/pubmed/1856227 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415000 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415000 RefSeq WP_000844874 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000844874 SMR P23862 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P23862 STRING 511145.b0467 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0467&targetmode=cogs STRING COG3923 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3923&targetmode=cogs UniProtKB PRIC_ECOLI http://www.uniprot.org/uniprot/PRIC_ECOLI UniProtKB-AC P23862 http://www.uniprot.org/uniprot/P23862 charge swissprot:PRIC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PRIC_ECOLI eggNOG COG3923 http://eggnogapi.embl.de/nog_data/html/tree/COG3923 eggNOG ENOG4108URS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108URS epestfind swissprot:PRIC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PRIC_ECOLI garnier swissprot:PRIC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PRIC_ECOLI helixturnhelix swissprot:PRIC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PRIC_ECOLI hmoment swissprot:PRIC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PRIC_ECOLI iep swissprot:PRIC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PRIC_ECOLI inforesidue swissprot:PRIC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PRIC_ECOLI octanol swissprot:PRIC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PRIC_ECOLI pepcoil swissprot:PRIC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PRIC_ECOLI pepdigest swissprot:PRIC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PRIC_ECOLI pepinfo swissprot:PRIC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PRIC_ECOLI pepnet swissprot:PRIC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PRIC_ECOLI pepstats swissprot:PRIC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PRIC_ECOLI pepwheel swissprot:PRIC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PRIC_ECOLI pepwindow swissprot:PRIC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PRIC_ECOLI sigcleave swissprot:PRIC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PRIC_ECOLI ## Database ID URL or Descriptions # BRENDA 4.1.1.18 2026 # BioGrid 4260777 2 # CATALYTIC ACTIVITY LDCI_ECOLI L-lysine = cadaverine + CO(2). # CDD cd00615 Orn_deC_like # COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI 597326; # EcoGene EG10131 cadA # FUNCTION LDCI_ECOLI Plays a role in pH homeostasis by consuming protons and neutralizing the acidic by-products of carbohydrate fermentation. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0008923 lysine decarboxylase activity; IMP:EcoCyc. # GO_function GO:0042802 identical protein binding; IPI:IntAct. # GO_process GO:0006554 lysine catabolic process; IMP:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # Gene3D 3.40.640.10 -; 1. # Gene3D 3.90.100.10 -; 1. # Gene3D 3.90.1150.10 -; 1. # INDUCTION At low pH in the presence of lysine, achieves maximal levels under anaerobic conditions. Expression controlled by CadC. {ECO:0000269|PubMed 1370290}. # INTERACTION LDCI_ECOLI Self; NbExp=7; IntAct=EBI-545922, EBI-545922; P52095 ldcC; NbExp=3; IntAct=EBI-545922, EBI-545944; P31473 ravA; NbExp=7; IntAct=EBI-545922, EBI-561223; # IntAct P0A9H3 20 # InterPro IPR000310 Orn/Lys/Arg_deCO2ase_major_dom # InterPro IPR005308 OKR_de-COase_N # InterPro IPR008286 Prn/Lys/Arg_de-COase_C # InterPro IPR011193 Orn/lys/arg_de-COase # InterPro IPR015421 PyrdxlP-dep_Trfase_major_sub1 # InterPro IPR015422 PyrdxlP-dep_Trfase_major_sub2 # InterPro IPR015424 PyrdxlP-dep_Trfase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00310 Lysine degradation # KEGG_Pathway ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis # Organism LDCI_ECOLI Escherichia coli (strain K12) # PATRIC 32123829 VBIEscCol129921_4263 # PDB 3N75 X-ray; 2.00 A; A/B/C/D/E=1-715 # PDB 3Q16 X-ray; 4.10 A; A/B/C/D/E=1-715 # PDB 4UPB EM; 11.00 A; A/B=1-715 # PDB 4UPF EM; 7.50 A; A=1-715 # PDB 5FKX EM; 6.10 A; A=1-711 # PDB 5FL2 EM; 6.20 A; A=1-711 # PIR B41842 B41842 # PIRSF PIRSF009393 Orn_decarb # PROSITE PS00703 OKR_DC_1 # Pfam PF01276 OKR_DC_1 # Pfam PF03709 OKR_DC_1_N # Pfam PF03711 OKR_DC_1_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LDCI_ECOLI Lysine decarboxylase, inducible # RefSeq NP_418555 NC_000913.3 # RefSeq WP_001295383 NZ_LN832404.1 # SIMILARITY Belongs to the Orn/Lys/Arg decarboxylase class-I family. {ECO 0000305}. # SUBCELLULAR LOCATION LDCI_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Homodecamer at pH 7.0/low ionic strength and dimer at pH 8.0/high ionic strength. Interacts with RavA. {ECO:0000269|PubMed 16301313}. # SUPFAM SSF53383 SSF53383 # SUPFAM SSF55904 SSF55904 # eggNOG COG1982 LUCA # eggNOG ENOG4105CXN Bacteria BLAST swissprot:LDCI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LDCI_ECOLI BioCyc ECOL316407:JW4092-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4092-MONOMER BioCyc EcoCyc:LYSDECARBOX-MONOMER http://biocyc.org/getid?id=EcoCyc:LYSDECARBOX-MONOMER BioCyc MetaCyc:LYSDECARBOX-MONOMER http://biocyc.org/getid?id=MetaCyc:LYSDECARBOX-MONOMER COG COG1982 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1982 DIP DIP-35646N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35646N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1021/bi00701a006 http://dx.doi.org/10.1021/bi00701a006 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M511172200 http://dx.doi.org/10.1074/jbc.M511172200 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1111/j.1365-2958.1989.tb00208.x http://dx.doi.org/10.1111/j.1365-2958.1989.tb00208.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.1.1.18 http://www.genome.jp/dbget-bin/www_bget?EC:4.1.1.18 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M67452 http://www.ebi.ac.uk/ena/data/view/M67452 EMBL M76411 http://www.ebi.ac.uk/ena/data/view/M76411 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 4.1.1.18 http://enzyme.expasy.org/EC/4.1.1.18 EchoBASE EB0129 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0129 EcoGene EG10131 http://www.ecogene.org/geneInfo.php?eg_id=EG10131 EnsemblBacteria AAC77092 http://www.ensemblgenomes.org/id/AAC77092 EnsemblBacteria AAC77092 http://www.ensemblgenomes.org/id/AAC77092 EnsemblBacteria BAE78134 http://www.ensemblgenomes.org/id/BAE78134 EnsemblBacteria BAE78134 http://www.ensemblgenomes.org/id/BAE78134 EnsemblBacteria BAE78134 http://www.ensemblgenomes.org/id/BAE78134 EnsemblBacteria b4131 http://www.ensemblgenomes.org/id/b4131 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0008923 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008923 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0006554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006554 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 3.40.640.10 http://www.cathdb.info/version/latest/superfamily/3.40.640.10 Gene3D 3.90.100.10 http://www.cathdb.info/version/latest/superfamily/3.90.100.10 Gene3D 3.90.1150.10 http://www.cathdb.info/version/latest/superfamily/3.90.1150.10 GeneID 948643 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948643 HOGENOM HOG000164394 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000164394&db=HOGENOM6 InParanoid P0A9H3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9H3 IntAct P0A9H3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9H3* IntEnz 4.1.1.18 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.1.18 InterPro IPR000310 http://www.ebi.ac.uk/interpro/entry/IPR000310 InterPro IPR005308 http://www.ebi.ac.uk/interpro/entry/IPR005308 InterPro IPR008286 http://www.ebi.ac.uk/interpro/entry/IPR008286 InterPro IPR011193 http://www.ebi.ac.uk/interpro/entry/IPR011193 InterPro IPR015421 http://www.ebi.ac.uk/interpro/entry/IPR015421 InterPro IPR015422 http://www.ebi.ac.uk/interpro/entry/IPR015422 InterPro IPR015424 http://www.ebi.ac.uk/interpro/entry/IPR015424 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4092 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4092 KEGG_Gene eco:b4131 http://www.genome.jp/dbget-bin/www_bget?eco:b4131 KEGG_Orthology KO:K01582 http://www.genome.jp/dbget-bin/www_bget?KO:K01582 KEGG_Pathway ko00310 http://www.genome.jp/kegg-bin/show_pathway?ko00310 KEGG_Pathway ko00960 http://www.genome.jp/kegg-bin/show_pathway?ko00960 KEGG_Reaction rn:R00462 http://www.genome.jp/dbget-bin/www_bget?rn:R00462 MINT MINT-1234345 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1234345 OMA PSFYEGM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PSFYEGM PDB 3N75 http://www.ebi.ac.uk/pdbe-srv/view/entry/3N75 PDB 3Q16 http://www.ebi.ac.uk/pdbe-srv/view/entry/3Q16 PDB 4UPB http://www.ebi.ac.uk/pdbe-srv/view/entry/4UPB PDB 4UPF http://www.ebi.ac.uk/pdbe-srv/view/entry/4UPF PDB 5FKX http://www.ebi.ac.uk/pdbe-srv/view/entry/5FKX PDB 5FL2 http://www.ebi.ac.uk/pdbe-srv/view/entry/5FL2 PDBsum 3N75 http://www.ebi.ac.uk/pdbsum/3N75 PDBsum 3Q16 http://www.ebi.ac.uk/pdbsum/3Q16 PDBsum 4UPB http://www.ebi.ac.uk/pdbsum/4UPB PDBsum 4UPF http://www.ebi.ac.uk/pdbsum/4UPF PDBsum 5FKX http://www.ebi.ac.uk/pdbsum/5FKX PDBsum 5FL2 http://www.ebi.ac.uk/pdbsum/5FL2 PROSITE PS00703 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00703 PSORT swissprot:LDCI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LDCI_ECOLI PSORT-B swissprot:LDCI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LDCI_ECOLI PSORT2 swissprot:LDCI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LDCI_ECOLI Pfam PF01276 http://pfam.xfam.org/family/PF01276 Pfam PF03709 http://pfam.xfam.org/family/PF03709 Pfam PF03711 http://pfam.xfam.org/family/PF03711 Phobius swissprot:LDCI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LDCI_ECOLI PhylomeDB P0A9H3 http://phylomedb.org/?seqid=P0A9H3 ProteinModelPortal P0A9H3 http://www.proteinmodelportal.org/query/uniprot/P0A9H3 PubMed 1370290 http://www.ncbi.nlm.nih.gov/pubmed/1370290 PubMed 1556085 http://www.ncbi.nlm.nih.gov/pubmed/1556085 PubMed 16301313 http://www.ncbi.nlm.nih.gov/pubmed/16301313 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2527331 http://www.ncbi.nlm.nih.gov/pubmed/2527331 PubMed 4204273 http://www.ncbi.nlm.nih.gov/pubmed/4204273 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_418555 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418555 RefSeq WP_001295383 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295383 SMR P0A9H3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9H3 STRING 511145.b4131 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4131&targetmode=cogs STRING COG1982 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1982&targetmode=cogs SUPFAM SSF53383 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53383 SUPFAM SSF55904 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55904 UniProtKB LDCI_ECOLI http://www.uniprot.org/uniprot/LDCI_ECOLI UniProtKB-AC P0A9H3 http://www.uniprot.org/uniprot/P0A9H3 charge swissprot:LDCI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LDCI_ECOLI eggNOG COG1982 http://eggnogapi.embl.de/nog_data/html/tree/COG1982 eggNOG ENOG4105CXN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CXN epestfind swissprot:LDCI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LDCI_ECOLI garnier swissprot:LDCI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LDCI_ECOLI helixturnhelix swissprot:LDCI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LDCI_ECOLI hmoment swissprot:LDCI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LDCI_ECOLI iep swissprot:LDCI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LDCI_ECOLI inforesidue swissprot:LDCI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LDCI_ECOLI octanol swissprot:LDCI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LDCI_ECOLI pepcoil swissprot:LDCI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LDCI_ECOLI pepdigest swissprot:LDCI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LDCI_ECOLI pepinfo swissprot:LDCI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LDCI_ECOLI pepnet swissprot:LDCI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LDCI_ECOLI pepstats swissprot:LDCI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LDCI_ECOLI pepwheel swissprot:LDCI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LDCI_ECOLI pepwindow swissprot:LDCI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LDCI_ECOLI sigcleave swissprot:LDCI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LDCI_ECOLI ## Database ID URL or Descriptions # BioGrid 4262329 6 # CATALYTIC ACTIVITY Propanoyl-CoA + succinate = propionate + succinyl-CoA. {ECO:0000269|PubMed 10769117}. # EcoGene EG12973 scpC # FUNCTION SCPC_ECOLI Catalyzes the transfer of coenzyme A from propionyl-CoA to succinate. Could be part of a pathway that converts succinate to propionate. {ECO 0000269|PubMed 10769117}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0003986 acetyl-CoA hydrolase activity; IBA:GO_Central. # GO_function GO:0008775 acetate CoA-transferase activity; IBA:GO_Central. # GO_function SCPC_ECOLI GO 0043821 propionyl-CoA succinate CoA-transferase activity; IDA EcoCyc. # GO_process GO:0006083 acetate metabolic process; IBA:GO_Central. # GO_process GO:0006084 acetyl-CoA metabolic process; IEA:InterPro. # GO_process GO:0019679 propionate metabolic process, methylcitrate cycle; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # IntAct P52043 9 # InterPro IPR003702 ActCoA_hydro # InterPro IPR017821 Succinate_CoA_transferase # InterPro IPR026888 AcetylCoA_hyd_C # Organism SCPC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21432 PTHR21432 # PATRIC 32121254 VBIEscCol129921_3015 # PIR G65076 G65076 # Pfam PF02550 AcetylCoA_hydro # Pfam PF13336 AcetylCoA_hyd_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Propionyl-CoA succinate CoA transferase # RefSeq NP_417395 NC_000913.3 # RefSeq WP_000449965 NZ_LN832404.1 # SIMILARITY Belongs to the acetyl-CoA hydrolase/transferase family. {ECO 0000305}. # TIGRFAMs TIGR03458 YgfH_subfam # eggNOG COG0427 LUCA # eggNOG ENOG4105CYC Bacteria BLAST swissprot:SCPC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SCPC_ECOLI BioCyc ECOL316407:JW2887-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2887-MONOMER BioCyc EcoCyc:G7517-MONOMER http://biocyc.org/getid?id=EcoCyc:G7517-MONOMER BioCyc MetaCyc:G7517-MONOMER http://biocyc.org/getid?id=MetaCyc:G7517-MONOMER DIP DIP-12167N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12167N DOI 10.1021/bi992888d http://dx.doi.org/10.1021/bi992888d DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.8.3.- http://www.genome.jp/dbget-bin/www_bget?EC:2.8.3.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 ENZYME 2.8.3.- http://enzyme.expasy.org/EC/2.8.3.- EchoBASE EB2800 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2800 EcoGene EG12973 http://www.ecogene.org/geneInfo.php?eg_id=EG12973 EnsemblBacteria AAC75957 http://www.ensemblgenomes.org/id/AAC75957 EnsemblBacteria AAC75957 http://www.ensemblgenomes.org/id/AAC75957 EnsemblBacteria BAE76984 http://www.ensemblgenomes.org/id/BAE76984 EnsemblBacteria BAE76984 http://www.ensemblgenomes.org/id/BAE76984 EnsemblBacteria BAE76984 http://www.ensemblgenomes.org/id/BAE76984 EnsemblBacteria b2920 http://www.ensemblgenomes.org/id/b2920 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003986 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003986 GO_function GO:0008775 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008775 GO_function GO:0043821 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043821 GO_process GO:0006083 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006083 GO_process GO:0006084 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006084 GO_process GO:0019679 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019679 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GeneID 947402 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947402 HOGENOM HOG000172597 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000172597&db=HOGENOM6 InParanoid P52043 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P52043 IntAct P52043 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P52043* IntEnz 2.8.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.8.3 InterPro IPR003702 http://www.ebi.ac.uk/interpro/entry/IPR003702 InterPro IPR017821 http://www.ebi.ac.uk/interpro/entry/IPR017821 InterPro IPR026888 http://www.ebi.ac.uk/interpro/entry/IPR026888 KEGG_Gene ecj:JW2887 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2887 KEGG_Gene eco:b2920 http://www.genome.jp/dbget-bin/www_bget?eco:b2920 MINT MINT-1232787 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1232787 OMA QAGIGNI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QAGIGNI PANTHER PTHR21432 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21432 PSORT swissprot:SCPC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SCPC_ECOLI PSORT-B swissprot:SCPC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SCPC_ECOLI PSORT2 swissprot:SCPC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SCPC_ECOLI Pfam PF02550 http://pfam.xfam.org/family/PF02550 Pfam PF13336 http://pfam.xfam.org/family/PF13336 Phobius swissprot:SCPC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SCPC_ECOLI PhylomeDB P52043 http://phylomedb.org/?seqid=P52043 ProteinModelPortal P52043 http://www.proteinmodelportal.org/query/uniprot/P52043 PubMed 10769117 http://www.ncbi.nlm.nih.gov/pubmed/10769117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417395 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417395 RefSeq WP_000449965 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000449965 SMR P52043 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P52043 STRING 511145.b2920 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2920&targetmode=cogs TIGRFAMs TIGR03458 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03458 UniProtKB SCPC_ECOLI http://www.uniprot.org/uniprot/SCPC_ECOLI UniProtKB-AC P52043 http://www.uniprot.org/uniprot/P52043 charge swissprot:SCPC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SCPC_ECOLI eggNOG COG0427 http://eggnogapi.embl.de/nog_data/html/tree/COG0427 eggNOG ENOG4105CYC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CYC epestfind swissprot:SCPC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SCPC_ECOLI garnier swissprot:SCPC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SCPC_ECOLI helixturnhelix swissprot:SCPC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SCPC_ECOLI hmoment swissprot:SCPC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SCPC_ECOLI iep swissprot:SCPC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SCPC_ECOLI inforesidue swissprot:SCPC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SCPC_ECOLI octanol swissprot:SCPC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SCPC_ECOLI pepcoil swissprot:SCPC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SCPC_ECOLI pepdigest swissprot:SCPC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SCPC_ECOLI pepinfo swissprot:SCPC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SCPC_ECOLI pepnet swissprot:SCPC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SCPC_ECOLI pepstats swissprot:SCPC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SCPC_ECOLI pepwheel swissprot:SCPC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SCPC_ECOLI pepwindow swissprot:SCPC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SCPC_ECOLI sigcleave swissprot:SCPC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SCPC_ECOLI ## Database ID URL or Descriptions # BioGrid 4259801 11 # EcoGene EG13594 yahJ # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # Gene3D 2.30.40.10 -; 1. # IntAct P77554 4 # InterPro IPR006311 TAT_signal # InterPro IPR011059 Metal-dep_hydrolase_composite # InterPro IPR013108 Amidohydro_3 # InterPro IPR032466 Metal_Hydrolase # Organism YAHJ_ECOLI Escherichia coli (strain K12) # PATRIC 32115777 VBIEscCol129921_0331 # PIR D64759 D64759 # PROSITE PS51318 TAT # PTM YAHJ_ECOLI Exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven. Can also be exported by the Sec system. # Pfam PF07969 Amidohydro_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAHJ_ECOLI Uncharacterized protein YahJ # RefSeq NP_414858 NC_000913.3 # RefSeq WP_000665120 NZ_LN832404.1 # SUPFAM SSF51338 SSF51338 # SUPFAM SSF51556 SSF51556 # eggNOG COG0402 LUCA # eggNOG ENOG4105DZC Bacteria BLAST swissprot:YAHJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAHJ_ECOLI BioCyc ECOL316407:JW0316-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0316-MONOMER BioCyc EcoCyc:G6189-MONOMER http://biocyc.org/getid?id=EcoCyc:G6189-MONOMER DIP DIP-11262N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11262N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M610507200 http://dx.doi.org/10.1074/jbc.M610507200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB3363 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3363 EcoGene EG13594 http://www.ecogene.org/geneInfo.php?eg_id=EG13594 EnsemblBacteria AAC73427 http://www.ensemblgenomes.org/id/AAC73427 EnsemblBacteria AAC73427 http://www.ensemblgenomes.org/id/AAC73427 EnsemblBacteria BAE76107 http://www.ensemblgenomes.org/id/BAE76107 EnsemblBacteria BAE76107 http://www.ensemblgenomes.org/id/BAE76107 EnsemblBacteria BAE76107 http://www.ensemblgenomes.org/id/BAE76107 EnsemblBacteria b0324 http://www.ensemblgenomes.org/id/b0324 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0016814 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016814 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 Gene3D 2.30.40.10 http://www.cathdb.info/version/latest/superfamily/2.30.40.10 GeneID 944976 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944976 HOGENOM HOG000184779 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000184779&db=HOGENOM6 InParanoid P77554 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77554 IntAct P77554 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77554* InterPro IPR006311 http://www.ebi.ac.uk/interpro/entry/IPR006311 InterPro IPR011059 http://www.ebi.ac.uk/interpro/entry/IPR011059 InterPro IPR013108 http://www.ebi.ac.uk/interpro/entry/IPR013108 InterPro IPR032466 http://www.ebi.ac.uk/interpro/entry/IPR032466 KEGG_Gene ecj:JW0316 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0316 KEGG_Gene eco:b0324 http://www.genome.jp/dbget-bin/www_bget?eco:b0324 MINT MINT-1299954 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1299954 OMA FRDMHIH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FRDMHIH PROSITE PS51318 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51318 PSORT swissprot:YAHJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAHJ_ECOLI PSORT-B swissprot:YAHJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAHJ_ECOLI PSORT2 swissprot:YAHJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAHJ_ECOLI Pfam PF07969 http://pfam.xfam.org/family/PF07969 Phobius swissprot:YAHJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAHJ_ECOLI PhylomeDB P77554 http://phylomedb.org/?seqid=P77554 ProteinModelPortal P77554 http://www.proteinmodelportal.org/query/uniprot/P77554 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17218314 http://www.ncbi.nlm.nih.gov/pubmed/17218314 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414858 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414858 RefSeq WP_000665120 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000665120 SMR P77554 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77554 STRING 511145.b0324 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0324&targetmode=cogs SUPFAM SSF51338 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51338 SUPFAM SSF51556 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51556 UniProtKB YAHJ_ECOLI http://www.uniprot.org/uniprot/YAHJ_ECOLI UniProtKB-AC P77554 http://www.uniprot.org/uniprot/P77554 charge swissprot:YAHJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAHJ_ECOLI eggNOG COG0402 http://eggnogapi.embl.de/nog_data/html/tree/COG0402 eggNOG ENOG4105DZC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DZC epestfind swissprot:YAHJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAHJ_ECOLI garnier swissprot:YAHJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAHJ_ECOLI helixturnhelix swissprot:YAHJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAHJ_ECOLI hmoment swissprot:YAHJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAHJ_ECOLI iep swissprot:YAHJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAHJ_ECOLI inforesidue swissprot:YAHJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAHJ_ECOLI octanol swissprot:YAHJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAHJ_ECOLI pepcoil swissprot:YAHJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAHJ_ECOLI pepdigest swissprot:YAHJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAHJ_ECOLI pepinfo swissprot:YAHJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAHJ_ECOLI pepnet swissprot:YAHJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAHJ_ECOLI pepstats swissprot:YAHJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAHJ_ECOLI pepwheel swissprot:YAHJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAHJ_ECOLI pepwindow swissprot:YAHJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAHJ_ECOLI sigcleave swissprot:YAHJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAHJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4262230 6 # EcoGene EG13955 ydhU # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0009055 electron carrier activity; IEA:InterPro. # GO_process GO:0022904 respiratory electron transport chain; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006091 generation of precursor metabolites and energy # INDUCTION Up-regulated by the oxygen-responsive transcription factor FNR under anaerobic conditions. Repressed in the presence of nitrate or nitrite via the two-component systems NarXL and NarPQ, respectively. {ECO:0000269|PubMed 18227264}. # IntAct P77409 3 # InterPro IPR011577 Cyt_b561_bac/Ni-Hgenase # InterPro IPR016174 Di-haem_cyt_TM # KEGG_Brite ko02000 Transporters # Organism PHSC_ECOLI Escherichia coli (strain K12) # PATRIC 32118646 VBIEscCol129921_1741 # PIR F64924 F64924 # Pfam PF01292 Ni_hydr_CYTB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PHSC_ECOLI Protein PhsC homolog # RefSeq NP_416185 NC_000913.3 # RefSeq WP_001069979 NZ_LN832404.1 # SUBCELLULAR LOCATION PHSC_ECOLI Cell inner membrane {ECO 0000305}; Multi- pass membrane protein {ECO 0000305}. # SUPFAM SSF81342 SSF81342 # eggNOG COG4117 LUCA # eggNOG ENOG4108NWD Bacteria BLAST swissprot:PHSC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PHSC_ECOLI BioCyc ECOL316407:JW1660-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1660-MONOMER BioCyc EcoCyc:G6898-MONOMER http://biocyc.org/getid?id=EcoCyc:G6898-MONOMER COG COG4117 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4117 DIP DIP-11740N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11740N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1099/mic.0.2007/012146-0 http://dx.doi.org/10.1099/mic.0.2007/012146-0 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U68703 http://www.ebi.ac.uk/ena/data/view/U68703 EchoBASE EB3713 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3713 EcoGene EG13955 http://www.ecogene.org/geneInfo.php?eg_id=EG13955 EnsemblBacteria AAC74740 http://www.ensemblgenomes.org/id/AAC74740 EnsemblBacteria AAC74740 http://www.ensemblgenomes.org/id/AAC74740 EnsemblBacteria BAA15442 http://www.ensemblgenomes.org/id/BAA15442 EnsemblBacteria BAA15442 http://www.ensemblgenomes.org/id/BAA15442 EnsemblBacteria BAA15442 http://www.ensemblgenomes.org/id/BAA15442 EnsemblBacteria b1670 http://www.ensemblgenomes.org/id/b1670 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_process GO:0022904 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022904 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GeneID 945608 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945608 HOGENOM HOG000004863 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000004863&db=HOGENOM6 InParanoid P77409 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77409 IntAct P77409 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77409* InterPro IPR011577 http://www.ebi.ac.uk/interpro/entry/IPR011577 InterPro IPR016174 http://www.ebi.ac.uk/interpro/entry/IPR016174 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1660 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1660 KEGG_Gene eco:b1670 http://www.genome.jp/dbget-bin/www_bget?eco:b1670 KEGG_Orthology KO:K08354 http://www.genome.jp/dbget-bin/www_bget?KO:K08354 MINT MINT-1292289 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1292289 OMA ITGWEEV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ITGWEEV PSORT swissprot:PHSC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PHSC_ECOLI PSORT-B swissprot:PHSC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PHSC_ECOLI PSORT2 swissprot:PHSC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PHSC_ECOLI Pfam PF01292 http://pfam.xfam.org/family/PF01292 Phobius swissprot:PHSC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PHSC_ECOLI PhylomeDB P77409 http://phylomedb.org/?seqid=P77409 ProteinModelPortal P77409 http://www.proteinmodelportal.org/query/uniprot/P77409 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18227264 http://www.ncbi.nlm.nih.gov/pubmed/18227264 PubMed 9023191 http://www.ncbi.nlm.nih.gov/pubmed/9023191 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416185 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416185 RefSeq WP_001069979 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001069979 STRING 511145.b1670 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1670&targetmode=cogs STRING COG4117 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4117&targetmode=cogs SUPFAM SSF81342 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81342 UniProtKB PHSC_ECOLI http://www.uniprot.org/uniprot/PHSC_ECOLI UniProtKB-AC P77409 http://www.uniprot.org/uniprot/P77409 charge swissprot:PHSC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PHSC_ECOLI eggNOG COG4117 http://eggnogapi.embl.de/nog_data/html/tree/COG4117 eggNOG ENOG4108NWD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108NWD epestfind swissprot:PHSC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PHSC_ECOLI garnier swissprot:PHSC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PHSC_ECOLI helixturnhelix swissprot:PHSC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PHSC_ECOLI hmoment swissprot:PHSC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PHSC_ECOLI iep swissprot:PHSC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PHSC_ECOLI inforesidue swissprot:PHSC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PHSC_ECOLI octanol swissprot:PHSC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PHSC_ECOLI pepcoil swissprot:PHSC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PHSC_ECOLI pepdigest swissprot:PHSC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PHSC_ECOLI pepinfo swissprot:PHSC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PHSC_ECOLI pepnet swissprot:PHSC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PHSC_ECOLI pepstats swissprot:PHSC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PHSC_ECOLI pepwheel swissprot:PHSC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PHSC_ECOLI pepwindow swissprot:PHSC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PHSC_ECOLI sigcleave swissprot:PHSC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PHSC_ECOLI ## Database ID URL or Descriptions # BioGrid 4260856 9 # EcoGene EG13325 ybiT # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016887 ATPase activity; IEA:InterPro. # GO_process GO:0006810 transport; IEA:UniProtKB-KW. # GO_process GO:0009409 response to cold; IEP:EcoCyc. # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # GOslim_process GO:0006950 response to stress # Gene3D 3.40.50.300 -; 3. # INTERACTION YBIT_ECOLI P0AAH8 sapF; NbExp=2; IntAct=EBI-558999, EBI-558765; # IntAct P0A9U3 3 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR027417 P-loop_NTPase # InterPro IPR032781 ABC_tran_Xtn # Organism YBIT_ECOLI Escherichia coli (strain K12) # PATRIC 32116843 VBIEscCol129921_0847 # PIR D64819 D64819 # PROSITE PS50893 ABC_TRANSPORTER_2; 2 # Pfam PF00005 ABC_tran; 2 # Pfam PF12848 ABC_tran_Xtn # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBIT_ECOLI Uncharacterized ABC transporter ATP-binding protein YbiT # RefSeq NP_415341 NC_000913.3 # RefSeq WP_000961458 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily. {ECO 0000305}. # SIMILARITY Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA; 2 # SUPFAM SSF52540 SSF52540; 2 # eggNOG COG0488 LUCA # eggNOG ENOG4105C5H Bacteria BLAST swissprot:YBIT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBIT_ECOLI BioCyc ECOL316407:JW0804-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0804-MONOMER BioCyc EcoCyc:G6423-MONOMER http://biocyc.org/getid?id=EcoCyc:G6423-MONOMER DIP DIP-11439N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11439N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3109 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3109 EcoGene EG13325 http://www.ecogene.org/geneInfo.php?eg_id=EG13325 EnsemblBacteria AAC73907 http://www.ensemblgenomes.org/id/AAC73907 EnsemblBacteria AAC73907 http://www.ensemblgenomes.org/id/AAC73907 EnsemblBacteria BAA35501 http://www.ensemblgenomes.org/id/BAA35501 EnsemblBacteria BAA35501 http://www.ensemblgenomes.org/id/BAA35501 EnsemblBacteria BAA35501 http://www.ensemblgenomes.org/id/BAA35501 EnsemblBacteria b0820 http://www.ensemblgenomes.org/id/b0820 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GO_process GO:0009409 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009409 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945440 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945440 HOGENOM HOG000271629 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000271629&db=HOGENOM6 InParanoid P0A9U3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9U3 IntAct P0A9U3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9U3* InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR032781 http://www.ebi.ac.uk/interpro/entry/IPR032781 KEGG_Gene ecj:JW0804 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0804 KEGG_Gene eco:b0820 http://www.genome.jp/dbget-bin/www_bget?eco:b0820 MINT MINT-1321005 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1321005 OMA WSENAKI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WSENAKI PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:YBIT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBIT_ECOLI PSORT-B swissprot:YBIT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBIT_ECOLI PSORT2 swissprot:YBIT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBIT_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Pfam PF12848 http://pfam.xfam.org/family/PF12848 Phobius swissprot:YBIT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBIT_ECOLI PhylomeDB P0A9U3 http://phylomedb.org/?seqid=P0A9U3 ProteinModelPortal P0A9U3 http://www.proteinmodelportal.org/query/uniprot/P0A9U3 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415341 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415341 RefSeq WP_000961458 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000961458 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P0A9U3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9U3 STRING 511145.b0820 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0820&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB YBIT_ECOLI http://www.uniprot.org/uniprot/YBIT_ECOLI UniProtKB-AC P0A9U3 http://www.uniprot.org/uniprot/P0A9U3 charge swissprot:YBIT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBIT_ECOLI eggNOG COG0488 http://eggnogapi.embl.de/nog_data/html/tree/COG0488 eggNOG ENOG4105C5H http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C5H epestfind swissprot:YBIT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBIT_ECOLI garnier swissprot:YBIT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBIT_ECOLI helixturnhelix swissprot:YBIT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBIT_ECOLI hmoment swissprot:YBIT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBIT_ECOLI iep swissprot:YBIT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBIT_ECOLI inforesidue swissprot:YBIT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBIT_ECOLI octanol swissprot:YBIT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBIT_ECOLI pepcoil swissprot:YBIT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBIT_ECOLI pepdigest swissprot:YBIT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBIT_ECOLI pepinfo swissprot:YBIT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBIT_ECOLI pepnet swissprot:YBIT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBIT_ECOLI pepstats swissprot:YBIT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBIT_ECOLI pepwheel swissprot:YBIT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBIT_ECOLI pepwindow swissprot:YBIT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBIT_ECOLI sigcleave swissprot:YBIT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBIT_ECOLI ## Database ID URL or Descriptions # AltName TDCG_ECOLI L-serine deaminase # BRENDA 4.3.1.17 2026 # BioGrid 4259263 9 # CATALYTIC ACTIVITY TDCG_ECOLI L-serine = pyruvate + NH(3). # COFACTOR TDCG_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000305}; Note=Binds 1 [4Fe-4S] cluster. {ECO 0000305}; # EcoGene EG12756 tdcG # GO_function GO:0003941 L-serine ammonia-lyase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0006094 gluconeogenesis; IEA:UniProtKB-KW. # GO_process GO:0009063 cellular amino acid catabolic process; IDA:EcoCyc. # GO_process GO:0070689 L-threonine catabolic process to propionate; IEA:UniProtKB-UniPathway. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.30.1330.90 -; 1. # IntAct P42630 3 # InterPro IPR004644 Fe-S_L-Ser_mono # InterPro IPR005130 Ser_deHydtase-like_asu # InterPro IPR005131 Ser_deHydtase_bsu # InterPro IPR029009 ASB_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00260 Glycine, serine and threonine metabolism # KEGG_Pathway ko00270 Cysteine and methionine metabolism # Organism TDCG_ECOLI Escherichia coli (strain K12) # PATHWAY TDCG_ECOLI Amino-acid degradation; L-threonine degradation via propanoate pathway. # PATRIC 32121640 VBIEscCol129921_3206 # Pfam PF03313 SDH_alpha # Pfam PF03315 SDH_beta # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TDCG_ECOLI L-serine dehydratase TdcG # RefSeq WP_000622126 NZ_LN832404.1 # RefSeq YP_026204 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA57915.1; Type=Frameshift; Positions=133; Evidence={ECO:0000305}; Sequence=AAA57916.1; Type=Frameshift; Positions=133; Evidence={ECO 0000305}; # SIMILARITY Belongs to the iron-sulfur dependent L-serine dehydratase family. {ECO 0000305}. # SUPFAM SSF143548 SSF143548 # TIGRFAMs TIGR00720 sda_mono # eggNOG COG1760 LUCA # eggNOG ENOG4105EJQ Bacteria BLAST swissprot:TDCG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TDCG_ECOLI BioCyc ECOL316407:JW5520-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5520-MONOMER BioCyc EcoCyc:LSERINEDEAM3-MONOMER http://biocyc.org/getid?id=EcoCyc:LSERINEDEAM3-MONOMER BioCyc MetaCyc:LSERINEDEAM3-MONOMER http://biocyc.org/getid?id=MetaCyc:LSERINEDEAM3-MONOMER COG COG1760 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1760 DIP DIP-10974N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10974N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1998.00696.x http://dx.doi.org/10.1046/j.1365-2958.1998.00696.x DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.3.1.17 http://www.genome.jp/dbget-bin/www_bget?EC:4.3.1.17 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 4.3.1.17 http://enzyme.expasy.org/EC/4.3.1.17 EchoBASE EB2610 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2610 EcoGene EG12756 http://www.ecogene.org/geneInfo.php?eg_id=EG12756 EnsemblBacteria AAT48169 http://www.ensemblgenomes.org/id/AAT48169 EnsemblBacteria AAT48169 http://www.ensemblgenomes.org/id/AAT48169 EnsemblBacteria BAE77160 http://www.ensemblgenomes.org/id/BAE77160 EnsemblBacteria BAE77160 http://www.ensemblgenomes.org/id/BAE77160 EnsemblBacteria BAE77160 http://www.ensemblgenomes.org/id/BAE77160 EnsemblBacteria b4471 http://www.ensemblgenomes.org/id/b4471 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003941 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003941 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0006094 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006094 GO_process GO:0009063 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009063 GO_process GO:0070689 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070689 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.30.1330.90 http://www.cathdb.info/version/latest/superfamily/3.30.1330.90 GeneID 2847724 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2847724 HOGENOM HOG000036732 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000036732&db=HOGENOM6 InParanoid P42630 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P42630 IntAct P42630 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P42630* IntEnz 4.3.1.17 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.3.1.17 InterPro IPR004644 http://www.ebi.ac.uk/interpro/entry/IPR004644 InterPro IPR005130 http://www.ebi.ac.uk/interpro/entry/IPR005130 InterPro IPR005131 http://www.ebi.ac.uk/interpro/entry/IPR005131 InterPro IPR029009 http://www.ebi.ac.uk/interpro/entry/IPR029009 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5520 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5520 KEGG_Gene eco:b4471 http://www.genome.jp/dbget-bin/www_bget?eco:b4471 KEGG_Orthology KO:K01752 http://www.genome.jp/dbget-bin/www_bget?KO:K01752 KEGG_Pathway ko00260 http://www.genome.jp/kegg-bin/show_pathway?ko00260 KEGG_Pathway ko00270 http://www.genome.jp/kegg-bin/show_pathway?ko00270 KEGG_Reaction rn:R00220 http://www.genome.jp/dbget-bin/www_bget?rn:R00220 KEGG_Reaction rn:R00590 http://www.genome.jp/dbget-bin/www_bget?rn:R00590 OMA WEVMQSC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WEVMQSC PSORT swissprot:TDCG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TDCG_ECOLI PSORT-B swissprot:TDCG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TDCG_ECOLI PSORT2 swissprot:TDCG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TDCG_ECOLI Pfam PF03313 http://pfam.xfam.org/family/PF03313 Pfam PF03315 http://pfam.xfam.org/family/PF03315 Phobius swissprot:TDCG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TDCG_ECOLI PhylomeDB P42630 http://phylomedb.org/?seqid=P42630 ProteinModelPortal P42630 http://www.proteinmodelportal.org/query/uniprot/P42630 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9484901 http://www.ncbi.nlm.nih.gov/pubmed/9484901 RefSeq WP_000622126 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000622126 RefSeq YP_026204 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026204 SMR P42630 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P42630 STRING 511145.b4471 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4471&targetmode=cogs STRING COG1760 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1760&targetmode=cogs SUPFAM SSF143548 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF143548 TIGRFAMs TIGR00720 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00720 UniProtKB TDCG_ECOLI http://www.uniprot.org/uniprot/TDCG_ECOLI UniProtKB-AC P42630 http://www.uniprot.org/uniprot/P42630 charge swissprot:TDCG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TDCG_ECOLI eggNOG COG1760 http://eggnogapi.embl.de/nog_data/html/tree/COG1760 eggNOG ENOG4105EJQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EJQ epestfind swissprot:TDCG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TDCG_ECOLI garnier swissprot:TDCG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TDCG_ECOLI helixturnhelix swissprot:TDCG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TDCG_ECOLI hmoment swissprot:TDCG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TDCG_ECOLI iep swissprot:TDCG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TDCG_ECOLI inforesidue swissprot:TDCG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TDCG_ECOLI octanol swissprot:TDCG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TDCG_ECOLI pepcoil swissprot:TDCG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TDCG_ECOLI pepdigest swissprot:TDCG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TDCG_ECOLI pepinfo swissprot:TDCG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TDCG_ECOLI pepnet swissprot:TDCG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TDCG_ECOLI pepstats swissprot:TDCG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TDCG_ECOLI pepwheel swissprot:TDCG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TDCG_ECOLI pepwindow swissprot:TDCG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TDCG_ECOLI sigcleave swissprot:TDCG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TDCG_ECOLI ## Database ID URL or Descriptions # AltName AROH_ECOLI 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase # AltName AROH_ECOLI DAHP synthase # AltName AROH_ECOLI Phospho-2-keto-3-deoxyheptonate aldolase # BioGrid 4260296 11 # CATALYTIC ACTIVITY AROH_ECOLI Phosphoenolpyruvate + D-erythrose 4-phosphate + H(2)O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate. # EcoGene EG10080 aroH # FUNCTION AROH_ECOLI Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP). # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_function GO:0003849 3-deoxy-7-phosphoheptulonate synthase activity; IDA:EcoliWiki. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0008652 cellular amino acid biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0009073 aromatic amino acid family biosynthetic process; IDA:EcoliWiki. # GO_process GO:0009423 chorismate biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.70 -; 1. # INTERACTION AROH_ECOLI P0A6F5 groL; NbExp=3; IntAct=EBI-1125143, EBI-543750; # IntAct P00887 5 # InterPro IPR006218 DAHP1/KDSA # InterPro IPR006219 DHAP_synth_1 # InterPro IPR013785 Aldolase_TIM # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis # MISCELLANEOUS AROH_ECOLI There are 3 DAHP synthases, AroH is feedback- inhibited by Trp. The other 2 DAHP synthases are Tyr- and Phe- sensitive, respectively. # Organism AROH_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21225 PTHR21225 # PATHWAY Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate step 1/7. # PATRIC 32118714 VBIEscCol129921_1775 # PIR H64928 ADECH # PIRSF PIRSF001361 DAHP_synthase # Pfam PF00793 DAHP_synth_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AROH_ECOLI Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive # RefSeq NP_416219 NC_000913.3 # RefSeq WP_001082229 NZ_LN832404.1 # SIMILARITY Belongs to the class-I DAHP synthase family. {ECO 0000305}. # TIGRFAMs TIGR00034 aroFGH # UniPathway UPA00053 UER00084 # eggNOG COG0722 LUCA # eggNOG ENOG4105E99 Bacteria BLAST swissprot:AROH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AROH_ECOLI BioCyc ECOL316407:JW1694-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1694-MONOMER BioCyc EcoCyc:AROH-MONOMER http://biocyc.org/getid?id=EcoCyc:AROH-MONOMER BioCyc MetaCyc:AROH-MONOMER http://biocyc.org/getid?id=MetaCyc:AROH-MONOMER COG COG0722 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0722 DIP DIP-6846N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-6846N DOI 10.1016/0022-2836(81)90334-X http://dx.doi.org/10.1016/0022-2836(81)90334-X DOI 10.1016/0378-1119(91)90544-L http://dx.doi.org/10.1016/0378-1119(91)90544-L DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.5.1.54 http://www.genome.jp/dbget-bin/www_bget?EC:2.5.1.54 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J04221 http://www.ebi.ac.uk/ena/data/view/J04221 EMBL M38266 http://www.ebi.ac.uk/ena/data/view/M38266 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00261 http://www.ebi.ac.uk/ena/data/view/V00261 EMBL X04373 http://www.ebi.ac.uk/ena/data/view/X04373 ENZYME 2.5.1.54 http://enzyme.expasy.org/EC/2.5.1.54 EchoBASE EB0078 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0078 EcoGene EG10080 http://www.ecogene.org/geneInfo.php?eg_id=EG10080 EnsemblBacteria AAC74774 http://www.ensemblgenomes.org/id/AAC74774 EnsemblBacteria AAC74774 http://www.ensemblgenomes.org/id/AAC74774 EnsemblBacteria BAA15473 http://www.ensemblgenomes.org/id/BAA15473 EnsemblBacteria BAA15473 http://www.ensemblgenomes.org/id/BAA15473 EnsemblBacteria BAA15473 http://www.ensemblgenomes.org/id/BAA15473 EnsemblBacteria b1704 http://www.ensemblgenomes.org/id/b1704 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003849 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003849 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0008652 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008652 GO_process GO:0009073 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009073 GO_process GO:0009423 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009423 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016765 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 946229 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946229 HOGENOM HOG000220501 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220501&db=HOGENOM6 InParanoid P00887 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00887 IntAct P00887 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00887* IntEnz 2.5.1.54 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.5.1.54 InterPro IPR006218 http://www.ebi.ac.uk/interpro/entry/IPR006218 InterPro IPR006219 http://www.ebi.ac.uk/interpro/entry/IPR006219 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1694 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1694 KEGG_Gene eco:b1704 http://www.genome.jp/dbget-bin/www_bget?eco:b1704 KEGG_Orthology KO:K01626 http://www.genome.jp/dbget-bin/www_bget?KO:K01626 KEGG_Pathway ko00400 http://www.genome.jp/kegg-bin/show_pathway?ko00400 KEGG_Reaction rn:R01826 http://www.genome.jp/dbget-bin/www_bget?rn:R01826 OMA PCLSWED http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PCLSWED PANTHER PTHR21225 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21225 PSORT swissprot:AROH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AROH_ECOLI PSORT-B swissprot:AROH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AROH_ECOLI PSORT2 swissprot:AROH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AROH_ECOLI Pfam PF00793 http://pfam.xfam.org/family/PF00793 Phobius swissprot:AROH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AROH_ECOLI PhylomeDB P00887 http://phylomedb.org/?seqid=P00887 ProteinModelPortal P00887 http://www.proteinmodelportal.org/query/uniprot/P00887 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1677907 http://www.ncbi.nlm.nih.gov/pubmed/1677907 PubMed 2903857 http://www.ncbi.nlm.nih.gov/pubmed/2903857 PubMed 6167722 http://www.ncbi.nlm.nih.gov/pubmed/6167722 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416219 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416219 RefSeq WP_001082229 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001082229 SMR P00887 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00887 STRING 511145.b1704 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1704&targetmode=cogs STRING COG0722 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0722&targetmode=cogs TIGRFAMs TIGR00034 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00034 UniProtKB AROH_ECOLI http://www.uniprot.org/uniprot/AROH_ECOLI UniProtKB-AC P00887 http://www.uniprot.org/uniprot/P00887 charge swissprot:AROH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AROH_ECOLI eggNOG COG0722 http://eggnogapi.embl.de/nog_data/html/tree/COG0722 eggNOG ENOG4105E99 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E99 epestfind swissprot:AROH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AROH_ECOLI garnier swissprot:AROH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AROH_ECOLI helixturnhelix swissprot:AROH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AROH_ECOLI hmoment swissprot:AROH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AROH_ECOLI iep swissprot:AROH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AROH_ECOLI inforesidue swissprot:AROH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AROH_ECOLI octanol swissprot:AROH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AROH_ECOLI pepcoil swissprot:AROH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AROH_ECOLI pepdigest swissprot:AROH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AROH_ECOLI pepinfo swissprot:AROH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AROH_ECOLI pepnet swissprot:AROH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AROH_ECOLI pepstats swissprot:AROH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AROH_ECOLI pepwheel swissprot:AROH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AROH_ECOLI pepwindow swissprot:AROH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AROH_ECOLI sigcleave swissprot:AROH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AROH_ECOLI ## Database ID URL or Descriptions # AltName GSPC_ECOLI Putative general secretion pathway protein C # BioGrid 4261296 198 # EcoGene EG12889 gspC # FUNCTION GSPC_ECOLI Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. {ECO 0000305}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0015627 type II protein secretion system complex; IEA:InterPro. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0008565 protein transporter activity; IEA:InterPro. # GO_process GO:0015628 protein secretion by the type II secretion system; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0008565 protein transporter activity # GOslim_process GO:0055085 transmembrane transport # Gene3D 2.30.42.10 -; 1. # INDUCTION Silenced by the DNA-binding protein H-NS under standard growth conditions. {ECO:0000269|PubMed 11118204}. # InterPro IPR001478 PDZ # InterPro IPR001639 T2SS_protein-C # InterPro IPR024961 T2SSC_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02044 M00331 Type II general secretion system # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko03070 Bacterial secretion system # MISCELLANEOUS GSPC_ECOLI Part of a cryptic operon that encodes proteins involved in type II secretion machinery in other organisms, but is not expressed in strain K12. # Organism GSPC_ECOLI Escherichia coli (strain K12) # PATRIC 32122080 VBIEscCol129921_3417 # PIR G65125 G65125 # PROSITE PS01141 T2SP_C # Pfam PF11356 T2SSC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GSPC_ECOLI Putative type II secretion system protein C # RefSeq NP_417783 NC_000913.3 # RefSeq WP_001142708 NZ_LN832404.1 # SIMILARITY Belongs to the GSP C family. {ECO 0000305}. # SUBCELLULAR LOCATION GSPC_ECOLI Cell inner membrane {ECO 0000305}; Single- pass membrane protein {ECO 0000305}. # SUPFAM SSF50156 SSF50156 # TIGRFAMs TIGR01713 typeII_sec_gspC # eggNOG COG3031 LUCA # eggNOG ENOG4107KSE Bacteria BLAST swissprot:GSPC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GSPC_ECOLI BioCyc ECOL316407:JW3286-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3286-MONOMER BioCyc EcoCyc:G7702-MONOMER http://biocyc.org/getid?id=EcoCyc:G7702-MONOMER BioCyc MetaCyc:G7702-MONOMER http://biocyc.org/getid?id=MetaCyc:G7702-MONOMER COG COG3031 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3031 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/emboj/19.24.6697 http://dx.doi.org/10.1093/emboj/19.24.6697 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2726 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2726 EcoGene EG12889 http://www.ecogene.org/geneInfo.php?eg_id=EG12889 EnsemblBacteria AAC76349 http://www.ensemblgenomes.org/id/AAC76349 EnsemblBacteria AAC76349 http://www.ensemblgenomes.org/id/AAC76349 EnsemblBacteria BAE77967 http://www.ensemblgenomes.org/id/BAE77967 EnsemblBacteria BAE77967 http://www.ensemblgenomes.org/id/BAE77967 EnsemblBacteria BAE77967 http://www.ensemblgenomes.org/id/BAE77967 EnsemblBacteria b3324 http://www.ensemblgenomes.org/id/b3324 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0015627 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015627 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GO_process GO:0015628 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015628 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 2.30.42.10 http://www.cathdb.info/version/latest/superfamily/2.30.42.10 GeneID 947824 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947824 HOGENOM HOG000125342 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125342&db=HOGENOM6 InterPro IPR001478 http://www.ebi.ac.uk/interpro/entry/IPR001478 InterPro IPR001639 http://www.ebi.ac.uk/interpro/entry/IPR001639 InterPro IPR024961 http://www.ebi.ac.uk/interpro/entry/IPR024961 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW3286 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3286 KEGG_Gene eco:b3324 http://www.genome.jp/dbget-bin/www_bget?eco:b3324 KEGG_Orthology KO:K02452 http://www.genome.jp/dbget-bin/www_bget?KO:K02452 KEGG_Pathway ko03070 http://www.genome.jp/kegg-bin/show_pathway?ko03070 OMA FAAICIC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FAAICIC PROSITE PS01141 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01141 PSORT swissprot:GSPC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GSPC_ECOLI PSORT-B swissprot:GSPC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GSPC_ECOLI PSORT2 swissprot:GSPC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GSPC_ECOLI Pfam PF11356 http://pfam.xfam.org/family/PF11356 Phobius swissprot:GSPC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GSPC_ECOLI ProteinModelPortal P45757 http://www.proteinmodelportal.org/query/uniprot/P45757 PubMed 11118204 http://www.ncbi.nlm.nih.gov/pubmed/11118204 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8655552 http://www.ncbi.nlm.nih.gov/pubmed/8655552 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417783 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417783 RefSeq WP_001142708 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001142708 SMR P45757 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45757 STRING 511145.b3324 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3324&targetmode=cogs STRING COG3031 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3031&targetmode=cogs SUPFAM SSF50156 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50156 TIGRFAMs TIGR01713 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01713 UniProtKB GSPC_ECOLI http://www.uniprot.org/uniprot/GSPC_ECOLI UniProtKB-AC P45757 http://www.uniprot.org/uniprot/P45757 charge swissprot:GSPC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GSPC_ECOLI eggNOG COG3031 http://eggnogapi.embl.de/nog_data/html/tree/COG3031 eggNOG ENOG4107KSE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107KSE epestfind swissprot:GSPC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GSPC_ECOLI garnier swissprot:GSPC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GSPC_ECOLI helixturnhelix swissprot:GSPC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GSPC_ECOLI hmoment swissprot:GSPC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GSPC_ECOLI iep swissprot:GSPC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GSPC_ECOLI inforesidue swissprot:GSPC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GSPC_ECOLI octanol swissprot:GSPC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GSPC_ECOLI pepcoil swissprot:GSPC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GSPC_ECOLI pepdigest swissprot:GSPC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GSPC_ECOLI pepinfo swissprot:GSPC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GSPC_ECOLI pepnet swissprot:GSPC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GSPC_ECOLI pepstats swissprot:GSPC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GSPC_ECOLI pepwheel swissprot:GSPC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GSPC_ECOLI pepwindow swissprot:GSPC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GSPC_ECOLI sigcleave swissprot:GSPC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GSPC_ECOLI ## Database ID URL or Descriptions # AltName ARFB_ECOLI Alternative ribosome-rescue factor B # BioGrid 4263371 6 # CATALYTIC ACTIVITY ARFB_ECOLI N-substituted aminoacyl-tRNA + H(2)O = N- substituted amino acid + tRNA. {ECO 0000269|PubMed 21051357, ECO 0000269|PubMed 21418110}. # DOMAIN ARFB_ECOLI The unstructured C-terminal region is required for ribosome binding and peptidyl-tRNA hydrolase activity. The C- terminal tail functions as a sensor to discriminate between stalled and actively translating ribosomes by binding in the mRNA entry channel downstream of the A site between the head and shoulder of the 30S subunit. This allows the N-terminal globular domain to sample different conformations, so that its conserved GGQ motif is optimally positioned in the peptidyltransferase center (PTC) to catalyze the hydrolysis of peptidyl-tRNA. The N- terminal domain of ArfB is bound in the A site of the 50S subunit next to the P-site tRNA. {ECO 0000269|PubMed 21051357, ECO 0000269|PubMed 21418110, ECO 0000269|PubMed 22422986}. # EcoGene EG12354 arfB # FUNCTION ARFB_ECOLI Rescues stalled ribosomes. Can hydrolyze peptidyl-tRNA on ribosomes stalled by both non-stop mRNAs and mRNAs that contain rare codon clusters. May function as a complementary rescue system when the stalled ribosome cannot be rescued by the SsrA(tmRNA)- SmpB quality control system or the alternative ribosome-rescue factor A. {ECO 0000269|PubMed 21051357, ECO 0000269|PubMed 21418110, ECO 0000269|PubMed 22422986}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0004045 aminoacyl-tRNA hydrolase activity; IDA:EcoCyc. # GO_function GO:0016150 translation release factor activity, codon nonspecific; IBA:GO_Central. # GO_function GO:0043022 ribosome binding; IDA:EcoCyc. # GO_process GO:0072344 rescue of stalled ribosome; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008135 translation factor activity, RNA binding # GOslim_process GO:0009058 biosynthetic process # IntAct P40711 8 # InterPro IPR000352 Pep_chain_release_fac_I_II # KEGG_Brite ko03012 Translation factors # Organism ARFB_ECOLI Escherichia coli (strain K12) # PATRIC 32115495 VBIEscCol129921_0199 # PDB 2RTX NMR; -; A=1-109 # PDB 4V95 X-ray; 3.20 A; AY=1-140 # PIR G64743 G64743 # PROSITE PS00745 RF_PROK_I # Pfam PF00472 RF-1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ARFB_ECOLI Peptidyl-tRNA hydrolase ArfB # RefSeq NP_414733 NC_000913.3 # RefSeq WP_000635537 NZ_LN832404.1 # SIMILARITY Belongs to the prokaryotic/mitochondrial release factor family. {ECO 0000305}. # SUBCELLULAR LOCATION ARFB_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Associated with 70S ribosomes and polysomes. {ECO:0000269|PubMed 22422986}. # eggNOG COG1186 LUCA # eggNOG ENOG4108YZN Bacteria BLAST swissprot:ARFB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARFB_ECOLI BioCyc ECOL316407:JW0187-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0187-MONOMER BioCyc EcoCyc:EG12354-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12354-MONOMER BioCyc MetaCyc:EG12354-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12354-MONOMER COG COG1186 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1186 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkq1097 http://dx.doi.org/10.1093/nar/gkq1097 DOI 10.1111/j.1365-2958.2011.07607.x http://dx.doi.org/10.1111/j.1365-2958.2011.07607.x DOI 10.1126/science.1217443 http://dx.doi.org/10.1126/science.1217443 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.1.29 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.1.29 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D49445 http://www.ebi.ac.uk/ena/data/view/D49445 EMBL L38619 http://www.ebi.ac.uk/ena/data/view/L38619 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18345 http://www.ebi.ac.uk/ena/data/view/U18345 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 ENZYME 3.1.1.29 http://enzyme.expasy.org/EC/3.1.1.29 EchoBASE EB2258 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2258 EcoGene EG12354 http://www.ecogene.org/geneInfo.php?eg_id=EG12354 EnsemblBacteria AAC73302 http://www.ensemblgenomes.org/id/AAC73302 EnsemblBacteria AAC73302 http://www.ensemblgenomes.org/id/AAC73302 EnsemblBacteria BAA77867 http://www.ensemblgenomes.org/id/BAA77867 EnsemblBacteria BAA77867 http://www.ensemblgenomes.org/id/BAA77867 EnsemblBacteria BAA77867 http://www.ensemblgenomes.org/id/BAA77867 EnsemblBacteria b0191 http://www.ensemblgenomes.org/id/b0191 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004045 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004045 GO_function GO:0016150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016150 GO_function GO:0043022 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043022 GO_process GO:0072344 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072344 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008135 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008135 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 946046 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946046 HOGENOM HOG000244440 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000244440&db=HOGENOM6 InParanoid P40711 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P40711 IntAct P40711 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P40711* IntEnz 3.1.1.29 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.1.29 InterPro IPR000352 http://www.ebi.ac.uk/interpro/entry/IPR000352 KEGG_Brite ko03012 http://www.genome.jp/dbget-bin/www_bget?ko03012 KEGG_Gene ecj:JW0187 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0187 KEGG_Gene eco:b0191 http://www.genome.jp/dbget-bin/www_bget?eco:b0191 KEGG_Orthology KO:K15034 http://www.genome.jp/dbget-bin/www_bget?KO:K15034 OMA KAQQHRT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KAQQHRT PDB 2RTX http://www.ebi.ac.uk/pdbe-srv/view/entry/2RTX PDB 4V95 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V95 PDBsum 2RTX http://www.ebi.ac.uk/pdbsum/2RTX PDBsum 4V95 http://www.ebi.ac.uk/pdbsum/4V95 PROSITE PS00745 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00745 PSORT swissprot:ARFB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARFB_ECOLI PSORT-B swissprot:ARFB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARFB_ECOLI PSORT2 swissprot:ARFB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARFB_ECOLI Pfam PF00472 http://pfam.xfam.org/family/PF00472 Phobius swissprot:ARFB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARFB_ECOLI PhylomeDB P40711 http://phylomedb.org/?seqid=P40711 ProteinModelPortal P40711 http://www.proteinmodelportal.org/query/uniprot/P40711 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21051357 http://www.ncbi.nlm.nih.gov/pubmed/21051357 PubMed 21418110 http://www.ncbi.nlm.nih.gov/pubmed/21418110 PubMed 22422986 http://www.ncbi.nlm.nih.gov/pubmed/22422986 PubMed 7635807 http://www.ncbi.nlm.nih.gov/pubmed/7635807 PubMed 7635808 http://www.ncbi.nlm.nih.gov/pubmed/7635808 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414733 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414733 RefSeq WP_000635537 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000635537 SMR P40711 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P40711 STRING 511145.b0191 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0191&targetmode=cogs STRING COG1186 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1186&targetmode=cogs UniProtKB ARFB_ECOLI http://www.uniprot.org/uniprot/ARFB_ECOLI UniProtKB-AC P40711 http://www.uniprot.org/uniprot/P40711 charge swissprot:ARFB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARFB_ECOLI eggNOG COG1186 http://eggnogapi.embl.de/nog_data/html/tree/COG1186 eggNOG ENOG4108YZN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108YZN epestfind swissprot:ARFB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARFB_ECOLI garnier swissprot:ARFB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARFB_ECOLI helixturnhelix swissprot:ARFB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARFB_ECOLI hmoment swissprot:ARFB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARFB_ECOLI iep swissprot:ARFB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARFB_ECOLI inforesidue swissprot:ARFB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARFB_ECOLI octanol swissprot:ARFB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARFB_ECOLI pepcoil swissprot:ARFB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARFB_ECOLI pepdigest swissprot:ARFB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARFB_ECOLI pepinfo swissprot:ARFB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARFB_ECOLI pepnet swissprot:ARFB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARFB_ECOLI pepstats swissprot:ARFB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARFB_ECOLI pepwheel swissprot:ARFB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARFB_ECOLI pepwindow swissprot:ARFB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARFB_ECOLI sigcleave swissprot:ARFB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARFB_ECOLI ## Database ID URL or Descriptions # BioGrid 4262002 20 # EcoGene EG10972 gutM # FUNCTION GUTM_ECOLI Positive regulator for glucitol operon expression. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IMP:EcoCyc. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # InterPro IPR009693 Glucitol_operon_activator # Organism GUTM_ECOLI Escherichia coli (strain K12) # PATRIC 32120810 VBIEscCol129921_2797 # PIR S01831 S01831 # PIRSF PIRSF011474 Glucitol_operon_activator # Pfam PF06923 GutM # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GUTM_ECOLI Glucitol operon activator protein # RefSeq NP_417186 NC_000913.3 # RefSeq WP_000252908 NZ_LN832404.1 # eggNOG COG4578 LUCA # eggNOG ENOG4105J92 Bacteria BLAST swissprot:GUTM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GUTM_ECOLI BioCyc ECOL316407:JW2675-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2675-MONOMER BioCyc EcoCyc:PD00345 http://biocyc.org/getid?id=EcoCyc:PD00345 COG COG4578 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4578 DOI 10.1016/0022-2836(88)90193-3 http://dx.doi.org/10.1016/0022-2836(88)90193-3 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J02708 http://www.ebi.ac.uk/ena/data/view/J02708 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EMBL X13463 http://www.ebi.ac.uk/ena/data/view/X13463 EchoBASE EB0965 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0965 EcoGene EG10972 http://www.ecogene.org/geneInfo.php?eg_id=EG10972 EnsemblBacteria AAC75748 http://www.ensemblgenomes.org/id/AAC75748 EnsemblBacteria AAC75748 http://www.ensemblgenomes.org/id/AAC75748 EnsemblBacteria BAA16567 http://www.ensemblgenomes.org/id/BAA16567 EnsemblBacteria BAA16567 http://www.ensemblgenomes.org/id/BAA16567 EnsemblBacteria BAA16567 http://www.ensemblgenomes.org/id/BAA16567 EnsemblBacteria b2706 http://www.ensemblgenomes.org/id/b2706 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 948938 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948938 HOGENOM HOG000124047 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000124047&db=HOGENOM6 InterPro IPR009693 http://www.ebi.ac.uk/interpro/entry/IPR009693 KEGG_Gene ecj:JW2675 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2675 KEGG_Gene eco:b2706 http://www.genome.jp/dbget-bin/www_bget?eco:b2706 KEGG_Orthology KO:K02466 http://www.genome.jp/dbget-bin/www_bget?KO:K02466 OMA QIALGWW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QIALGWW PSORT swissprot:GUTM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GUTM_ECOLI PSORT-B swissprot:GUTM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GUTM_ECOLI PSORT2 swissprot:GUTM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GUTM_ECOLI Pfam PF06923 http://pfam.xfam.org/family/PF06923 Phobius swissprot:GUTM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GUTM_ECOLI ProteinModelPortal P15081 http://www.proteinmodelportal.org/query/uniprot/P15081 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3062173 http://www.ncbi.nlm.nih.gov/pubmed/3062173 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417186 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417186 RefSeq WP_000252908 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000252908 STRING 511145.b2706 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2706&targetmode=cogs STRING COG4578 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4578&targetmode=cogs UniProtKB GUTM_ECOLI http://www.uniprot.org/uniprot/GUTM_ECOLI UniProtKB-AC P15081 http://www.uniprot.org/uniprot/P15081 charge swissprot:GUTM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GUTM_ECOLI eggNOG COG4578 http://eggnogapi.embl.de/nog_data/html/tree/COG4578 eggNOG ENOG4105J92 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105J92 epestfind swissprot:GUTM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GUTM_ECOLI garnier swissprot:GUTM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GUTM_ECOLI helixturnhelix swissprot:GUTM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GUTM_ECOLI hmoment swissprot:GUTM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GUTM_ECOLI iep swissprot:GUTM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GUTM_ECOLI inforesidue swissprot:GUTM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GUTM_ECOLI octanol swissprot:GUTM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GUTM_ECOLI pepcoil swissprot:GUTM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GUTM_ECOLI pepdigest swissprot:GUTM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GUTM_ECOLI pepinfo swissprot:GUTM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GUTM_ECOLI pepnet swissprot:GUTM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GUTM_ECOLI pepstats swissprot:GUTM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GUTM_ECOLI pepwheel swissprot:GUTM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GUTM_ECOLI pepwindow swissprot:GUTM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GUTM_ECOLI sigcleave swissprot:GUTM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GUTM_ECOLI ## Database ID URL or Descriptions # BioGrid 4262025 9 # EcoGene EG14183 eutG # FUNCTION EUTG_ECOLI May act on the acetaldehyde produced from the degradation of ethanolamine. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0004022 alcohol dehydrogenase (NAD) activity; IMP:CACAO. # GO_function GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:InterPro. # GO_process GO:0046336 ethanolamine catabolic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # InterPro IPR001670 ADH_Fe # InterPro IPR018211 ADH_Fe_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko00010 Glycolysis / Gluconeogenesis # Organism EUTG_ECOLI Escherichia coli (strain K12) # PATHWAY EUTG_ECOLI Amine and polyamine degradation; ethanolamine degradation. # PATRIC 32120289 VBIEscCol129921_2547 # PIR D65020 D65020 # PROSITE PS00060 ADH_IRON_2 # PROSITE PS00913 ADH_IRON_1 # Pfam PF00465 Fe-ADH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EUTG_ECOLI Ethanolamine utilization protein EutG # RefSeq NP_416948 NC_000913.3 # RefSeq WP_001326575 NZ_LN832404.1 # SIMILARITY Belongs to the iron-containing alcohol dehydrogenase family. {ECO 0000305}. # eggNOG COG1454 LUCA # eggNOG ENOG4105C0A Bacteria BLAST swissprot:EUTG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EUTG_ECOLI BioCyc ECOL316407:JW2437-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2437-MONOMER BioCyc EcoCyc:G7283-MONOMER http://biocyc.org/getid?id=EcoCyc:G7283-MONOMER COG COG1454 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1454 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.1.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.1.-.- http://enzyme.expasy.org/EC/1.1.-.- EchoBASE EB3935 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3935 EcoGene EG14183 http://www.ecogene.org/geneInfo.php?eg_id=EG14183 EnsemblBacteria AAC75506 http://www.ensemblgenomes.org/id/AAC75506 EnsemblBacteria AAC75506 http://www.ensemblgenomes.org/id/AAC75506 EnsemblBacteria BAA16331 http://www.ensemblgenomes.org/id/BAA16331 EnsemblBacteria BAA16331 http://www.ensemblgenomes.org/id/BAA16331 EnsemblBacteria BAA16331 http://www.ensemblgenomes.org/id/BAA16331 EnsemblBacteria b2453 http://www.ensemblgenomes.org/id/b2453 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004022 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004022 GO_function GO:0016616 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016616 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0046336 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046336 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 946233 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946233 HOGENOM HOG000243333 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000243333&db=HOGENOM6 InParanoid P76553 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76553 IntAct P76553 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76553* IntEnz 1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1 InterPro IPR001670 http://www.ebi.ac.uk/interpro/entry/IPR001670 InterPro IPR018211 http://www.ebi.ac.uk/interpro/entry/IPR018211 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW2437 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2437 KEGG_Gene eco:b2453 http://www.genome.jp/dbget-bin/www_bget?eco:b2453 KEGG_Orthology KO:K04022 http://www.genome.jp/dbget-bin/www_bget?KO:K04022 KEGG_Pathway ko00010 http://www.genome.jp/kegg-bin/show_pathway?ko00010 KEGG_Reaction rn:R00754 http://www.genome.jp/dbget-bin/www_bget?rn:R00754 OMA TEGVPPH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TEGVPPH PROSITE PS00060 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00060 PROSITE PS00913 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00913 PSORT swissprot:EUTG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EUTG_ECOLI PSORT-B swissprot:EUTG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EUTG_ECOLI PSORT2 swissprot:EUTG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EUTG_ECOLI Pfam PF00465 http://pfam.xfam.org/family/PF00465 Phobius swissprot:EUTG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EUTG_ECOLI PhylomeDB P76553 http://phylomedb.org/?seqid=P76553 ProteinModelPortal P76553 http://www.proteinmodelportal.org/query/uniprot/P76553 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416948 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416948 RefSeq WP_001326575 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001326575 SMR P76553 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76553 STRING 511145.b2453 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2453&targetmode=cogs STRING COG1454 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1454&targetmode=cogs UniProtKB EUTG_ECOLI http://www.uniprot.org/uniprot/EUTG_ECOLI UniProtKB-AC P76553 http://www.uniprot.org/uniprot/P76553 charge swissprot:EUTG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EUTG_ECOLI eggNOG COG1454 http://eggnogapi.embl.de/nog_data/html/tree/COG1454 eggNOG ENOG4105C0A http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C0A epestfind swissprot:EUTG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EUTG_ECOLI garnier swissprot:EUTG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EUTG_ECOLI helixturnhelix swissprot:EUTG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EUTG_ECOLI hmoment swissprot:EUTG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EUTG_ECOLI iep swissprot:EUTG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EUTG_ECOLI inforesidue swissprot:EUTG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EUTG_ECOLI octanol swissprot:EUTG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EUTG_ECOLI pepcoil swissprot:EUTG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EUTG_ECOLI pepdigest swissprot:EUTG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EUTG_ECOLI pepinfo swissprot:EUTG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EUTG_ECOLI pepnet swissprot:EUTG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EUTG_ECOLI pepstats swissprot:EUTG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EUTG_ECOLI pepwheel swissprot:EUTG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EUTG_ECOLI pepwindow swissprot:EUTG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EUTG_ECOLI sigcleave swissprot:EUTG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EUTG_ECOLI ## Database ID URL or Descriptions # AltName YCIA_ECOLI Protein P14 # BRENDA 3.1.2 2026 # BRENDA 3.1.2.20 2026 # BioGrid 4262997 15 # EcoGene EG11121 yciA # FUNCTION YCIA_ECOLI Catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA. {ECO 0000269|PubMed 15808744}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0047617 acyl-CoA hydrolase activity; IDA:EcoCyc. # GO_process GO:0006631 fatty acid metabolic process; IBA:GO_Central. # GO_process GO:0006637 acyl-CoA metabolic process; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.10.129.10 -; 1. # IntAct P0A8Z0 14 # InterPro IPR006683 Thioestr_dom # InterPro IPR029069 HotDog_dom # InterPro IPR033120 HOTDOG_ACOT # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01004 Lipid biosynthesis proteins # KEGG_Pathway ko01040 Biosynthesis of unsaturated fatty acids # Organism YCIA_ECOLI Escherichia coli (strain K12) # PATRIC 32117766 VBIEscCol129921_1303 # PDB 2G6S Model; -; A=1-132 # PIR A05224 A05224 # PROSITE PS51770 HOTDOG_ACOT # Pfam PF03061 4HBT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCIA_ECOLI Acyl-CoA thioester hydrolase YciA # RefSeq NP_415769 NC_000913.3 # RefSeq WP_000108160 NZ_LN832404.1 # SIMILARITY Belongs to the acyl coenzyme A hydrolase family. {ECO 0000305}. # SIMILARITY Contains 1 HotDog ACOT-type domain. {ECO:0000255|PROSITE-ProRule PRU01106}. # SUPFAM SSF54637 SSF54637 # eggNOG COG1607 LUCA # eggNOG ENOG4105NAU Bacteria BLAST swissprot:YCIA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCIA_ECOLI BioCyc ECOL316407:JW1245-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1245-MONOMER BioCyc EcoCyc:EG11121-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11121-MONOMER BioCyc MetaCyc:EG11121-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11121-MONOMER COG COG1607 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1607 DIP DIP-35956N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35956N DOI 10.1016/S0092-8674(85)80030-1 http://dx.doi.org/10.1016/S0092-8674(85)80030-1 DOI 10.1016/j.fmrre.2004.12.006 http://dx.doi.org/10.1016/j.fmrre.2004.12.006 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.2.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.2.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K00431 http://www.ebi.ac.uk/ena/data/view/K00431 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U24195 http://www.ebi.ac.uk/ena/data/view/U24195 EMBL U24196 http://www.ebi.ac.uk/ena/data/view/U24196 EMBL U24197 http://www.ebi.ac.uk/ena/data/view/U24197 EMBL U24198 http://www.ebi.ac.uk/ena/data/view/U24198 EMBL U24199 http://www.ebi.ac.uk/ena/data/view/U24199 EMBL U24200 http://www.ebi.ac.uk/ena/data/view/U24200 EMBL U24201 http://www.ebi.ac.uk/ena/data/view/U24201 EMBL U24202 http://www.ebi.ac.uk/ena/data/view/U24202 EMBL U24203 http://www.ebi.ac.uk/ena/data/view/U24203 EMBL U24204 http://www.ebi.ac.uk/ena/data/view/U24204 EMBL U24205 http://www.ebi.ac.uk/ena/data/view/U24205 EMBL U24206 http://www.ebi.ac.uk/ena/data/view/U24206 ENZYME 3.1.2.- http://enzyme.expasy.org/EC/3.1.2.- EchoBASE EB1111 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1111 EcoGene EG11121 http://www.ecogene.org/geneInfo.php?eg_id=EG11121 EnsemblBacteria AAC74335 http://www.ensemblgenomes.org/id/AAC74335 EnsemblBacteria AAC74335 http://www.ensemblgenomes.org/id/AAC74335 EnsemblBacteria BAA14785 http://www.ensemblgenomes.org/id/BAA14785 EnsemblBacteria BAA14785 http://www.ensemblgenomes.org/id/BAA14785 EnsemblBacteria BAA14785 http://www.ensemblgenomes.org/id/BAA14785 EnsemblBacteria b1253 http://www.ensemblgenomes.org/id/b1253 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0047617 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047617 GO_process GO:0006631 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006631 GO_process GO:0006637 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006637 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.10.129.10 http://www.cathdb.info/version/latest/superfamily/3.10.129.10 GeneID 946634 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946634 HOGENOM HOG000044841 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000044841&db=HOGENOM6 InParanoid P0A8Z0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8Z0 IntAct P0A8Z0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8Z0* IntEnz 3.1.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.2 InterPro IPR006683 http://www.ebi.ac.uk/interpro/entry/IPR006683 InterPro IPR029069 http://www.ebi.ac.uk/interpro/entry/IPR029069 InterPro IPR033120 http://www.ebi.ac.uk/interpro/entry/IPR033120 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01004 http://www.genome.jp/dbget-bin/www_bget?ko01004 KEGG_Gene ecj:JW1245 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1245 KEGG_Gene eco:b1253 http://www.genome.jp/dbget-bin/www_bget?eco:b1253 KEGG_Orthology KO:K10806 http://www.genome.jp/dbget-bin/www_bget?KO:K10806 KEGG_Pathway ko01040 http://www.genome.jp/kegg-bin/show_pathway?ko01040 OMA VNVEVWV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VNVEVWV PDB 2G6S http://www.ebi.ac.uk/pdbe-srv/view/entry/2G6S PDBsum 2G6S http://www.ebi.ac.uk/pdbsum/2G6S PROSITE PS51770 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51770 PSORT swissprot:YCIA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCIA_ECOLI PSORT-B swissprot:YCIA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCIA_ECOLI PSORT2 swissprot:YCIA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCIA_ECOLI Pfam PF03061 http://pfam.xfam.org/family/PF03061 Phobius swissprot:YCIA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCIA_ECOLI PhylomeDB P0A8Z0 http://phylomedb.org/?seqid=P0A8Z0 ProteinModelPortal P0A8Z0 http://www.proteinmodelportal.org/query/uniprot/P0A8Z0 PubMed 15808744 http://www.ncbi.nlm.nih.gov/pubmed/15808744 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2985285 http://www.ncbi.nlm.nih.gov/pubmed/2985285 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415769 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415769 RefSeq WP_000108160 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000108160 SMR P0A8Z0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8Z0 STRING 511145.b1253 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1253&targetmode=cogs STRING COG1607 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1607&targetmode=cogs SUPFAM SSF54637 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54637 UniProtKB YCIA_ECOLI http://www.uniprot.org/uniprot/YCIA_ECOLI UniProtKB-AC P0A8Z0 http://www.uniprot.org/uniprot/P0A8Z0 charge swissprot:YCIA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCIA_ECOLI eggNOG COG1607 http://eggnogapi.embl.de/nog_data/html/tree/COG1607 eggNOG ENOG4105NAU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105NAU epestfind swissprot:YCIA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCIA_ECOLI garnier swissprot:YCIA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCIA_ECOLI helixturnhelix swissprot:YCIA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCIA_ECOLI hmoment swissprot:YCIA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCIA_ECOLI iep swissprot:YCIA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCIA_ECOLI inforesidue swissprot:YCIA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCIA_ECOLI octanol swissprot:YCIA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCIA_ECOLI pepcoil swissprot:YCIA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCIA_ECOLI pepdigest swissprot:YCIA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCIA_ECOLI pepinfo swissprot:YCIA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCIA_ECOLI pepnet swissprot:YCIA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCIA_ECOLI pepstats swissprot:YCIA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCIA_ECOLI pepwheel swissprot:YCIA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCIA_ECOLI pepwindow swissprot:YCIA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCIA_ECOLI sigcleave swissprot:YCIA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCIA_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES CYSZ_ECOLI Kinetic parameters KM=0.72 uM for sulfate {ECO 0000269|PubMed 24657232}; KM=1.3 uM for sulfate (in the presence of 5 uM sulfite) {ECO 0000269|PubMed 24657232}; # BioGrid 4259702 8 # ENZYME REGULATION Inhibited by sulfite. {ECO:0000269|PubMed 24657232}. # EcoGene EG10003 cysZ # FUNCTION CYSZ_ECOLI High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway. Does not transport thiosulfate. {ECO 0000269|PubMed 24657232}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_function CYSZ_ECOLI GO 0009675 high-affinity sulfate proton symporter activity; IDA EcoCyc. # GO_function GO:0015116 sulfate transmembrane transporter activity; IDA:EcoCyc. # GO_process GO:0000103 sulfate assimilation; IMP:EcoCyc. # GO_process GO:0008652 cellular amino acid biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0019344 cysteine biosynthetic process; IDA:EcoCyc. # GO_process GO:1902358 sulfate transmembrane transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0055085 transmembrane transport # HAMAP MF_00468 CysZ # InterPro IPR022985 Sulfate_CysZ # Organism CYSZ_ECOLI Escherichia coli (strain K12) # PATRIC 32120209 VBIEscCol129921_2507 # PIR D65015 BVECCZ # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CYSZ_ECOLI Sulfate transporter CysZ {ECO 0000255|HAMAP-Rule MF_00468, ECO 0000303|PubMed 24657232} # RefSeq NP_416908 NC_000913.3 # RefSeq WP_000254839 NZ_LN832404.1 # SIMILARITY Belongs to the CysZ family. {ECO:0000255|HAMAP- Rule MF_00468, ECO:0000305}. # SUBCELLULAR LOCATION CYSZ_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_00468, ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255|HAMAP-Rule MF_00468}. # TCDB 2.A.121.1 the sulfate transporter (cysz) family # eggNOG COG2981 LUCA # eggNOG ENOG4105EXN Bacteria BLAST swissprot:CYSZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CYSZ_ECOLI BioCyc ECOL316407:JW2406-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2406-MONOMER BioCyc EcoCyc:EG10003-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10003-MONOMER COG COG2981 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2981 DOI 10.1016/S0092-8674(00)81838-3 http://dx.doi.org/10.1016/S0092-8674(00)81838-3 DOI 10.1016/j.bbamem.2014.03.003 http://dx.doi.org/10.1016/j.bbamem.2014.03.003 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1365-2958.1988.tb00089.x http://dx.doi.org/10.1111/j.1365-2958.1988.tb00089.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M21451 http://www.ebi.ac.uk/ena/data/view/M21451 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U74650 http://www.ebi.ac.uk/ena/data/view/U74650 EMBL X12615 http://www.ebi.ac.uk/ena/data/view/X12615 EchoBASE EB0003 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0003 EcoGene EG10003 http://www.ecogene.org/geneInfo.php?eg_id=EG10003 EnsemblBacteria AAC75466 http://www.ensemblgenomes.org/id/AAC75466 EnsemblBacteria AAC75466 http://www.ensemblgenomes.org/id/AAC75466 EnsemblBacteria BAA16287 http://www.ensemblgenomes.org/id/BAA16287 EnsemblBacteria BAA16287 http://www.ensemblgenomes.org/id/BAA16287 EnsemblBacteria BAA16287 http://www.ensemblgenomes.org/id/BAA16287 EnsemblBacteria b2413 http://www.ensemblgenomes.org/id/b2413 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0009675 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009675 GO_function GO:0015116 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015116 GO_process GO:0000103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000103 GO_process GO:0008652 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008652 GO_process GO:0019344 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019344 GO_process GO:1902358 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902358 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 946875 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946875 HAMAP MF_00468 http://hamap.expasy.org/unirule/MF_00468 HOGENOM HOG000273989 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000273989&db=HOGENOM6 InParanoid P0A6J3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6J3 InterPro IPR022985 http://www.ebi.ac.uk/interpro/entry/IPR022985 KEGG_Gene ecj:JW2406 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2406 KEGG_Gene eco:b2413 http://www.genome.jp/dbget-bin/www_bget?eco:b2413 KEGG_Orthology KO:K06203 http://www.genome.jp/dbget-bin/www_bget?KO:K06203 OMA ATLFWVR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ATLFWVR PSORT swissprot:CYSZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CYSZ_ECOLI PSORT-B swissprot:CYSZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CYSZ_ECOLI PSORT2 swissprot:CYSZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CYSZ_ECOLI Phobius swissprot:CYSZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CYSZ_ECOLI PhylomeDB P0A6J3 http://phylomedb.org/?seqid=P0A6J3 ProteinModelPortal P0A6J3 http://www.proteinmodelportal.org/query/uniprot/P0A6J3 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 24657232 http://www.ncbi.nlm.nih.gov/pubmed/24657232 PubMed 3062311 http://www.ncbi.nlm.nih.gov/pubmed/3062311 PubMed 3290198 http://www.ncbi.nlm.nih.gov/pubmed/3290198 PubMed 9008158 http://www.ncbi.nlm.nih.gov/pubmed/9008158 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416908 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416908 RefSeq WP_000254839 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000254839 STRING 511145.b2413 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2413&targetmode=cogs STRING COG2981 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2981&targetmode=cogs TCDB 2.A.121.1 http://www.tcdb.org/search/result.php?tc=2.A.121.1 UniProtKB CYSZ_ECOLI http://www.uniprot.org/uniprot/CYSZ_ECOLI UniProtKB-AC P0A6J3 http://www.uniprot.org/uniprot/P0A6J3 charge swissprot:CYSZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CYSZ_ECOLI eggNOG COG2981 http://eggnogapi.embl.de/nog_data/html/tree/COG2981 eggNOG ENOG4105EXN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EXN epestfind swissprot:CYSZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CYSZ_ECOLI garnier swissprot:CYSZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CYSZ_ECOLI helixturnhelix swissprot:CYSZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CYSZ_ECOLI hmoment swissprot:CYSZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CYSZ_ECOLI iep swissprot:CYSZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CYSZ_ECOLI inforesidue swissprot:CYSZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CYSZ_ECOLI octanol swissprot:CYSZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CYSZ_ECOLI pepcoil swissprot:CYSZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CYSZ_ECOLI pepdigest swissprot:CYSZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CYSZ_ECOLI pepinfo swissprot:CYSZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CYSZ_ECOLI pepnet swissprot:CYSZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CYSZ_ECOLI pepstats swissprot:CYSZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CYSZ_ECOLI pepwheel swissprot:CYSZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CYSZ_ECOLI pepwindow swissprot:CYSZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CYSZ_ECOLI sigcleave swissprot:CYSZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CYSZ_ECOLI ## Database ID URL or Descriptions # FUNCTION INSD7_ECOLI Involved in the transposition of the insertion sequence IS2. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006310 DNA recombination; IEA:UniProtKB-KW. # GO_process GO:0015074 DNA integration; IEA:InterPro. # GO_process GO:0032196 transposition; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 3.30.420.10 -; 1. # InterPro IPR001584 Integrase_cat-core # InterPro IPR012337 RNaseH-like_dom # InterPro IPR025948 HTH-like_dom # Organism INSD7_ECOLI Escherichia coli (strain K12) # PIR A64764 C65092 # PROSITE PS50994 INTEGRASE # Pfam PF00665 rve # Pfam PF13276 HTH_21 # RecName INSD7_ECOLI Transposase InsD for insertion element IS2 on F plasmid # RefSeq NP_061399 NC_002483.1 # RefSeq WP_000376502 NZ_LN832404.1 # SIMILARITY Contains 1 integrase catalytic domain. {ECO:0000255|PROSITE-ProRule PRU00457}. # SUPFAM SSF53098 SSF53098 # eggNOG ENOG4108MVM Bacteria # eggNOG ENOG410Z4Y8 LUCA BLAST swissprot:INSD7_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSD7_ECOLI EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0015074 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015074 GO_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 3.30.420.10 http://www.cathdb.info/version/latest/superfamily/3.30.420.10 GeneID 1263540 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263540 InterPro IPR001584 http://www.ebi.ac.uk/interpro/entry/IPR001584 InterPro IPR012337 http://www.ebi.ac.uk/interpro/entry/IPR012337 InterPro IPR025948 http://www.ebi.ac.uk/interpro/entry/IPR025948 PROSITE PS50994 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50994 PSORT swissprot:INSD7_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSD7_ECOLI PSORT-B swissprot:INSD7_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSD7_ECOLI PSORT2 swissprot:INSD7_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSD7_ECOLI Pfam PF00665 http://pfam.xfam.org/family/PF00665 Pfam PF13276 http://pfam.xfam.org/family/PF13276 Phobius swissprot:INSD7_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSD7_ECOLI PhylomeDB P0CF59 http://phylomedb.org/?seqid=P0CF59 ProteinModelPortal P0CF59 http://www.proteinmodelportal.org/query/uniprot/P0CF59 RefSeq NP_061399 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061399 RefSeq WP_000376502 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000376502 SMR P0CF59 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0CF59 STRING 511145.b4273 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4273&targetmode=cogs SUPFAM SSF53098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098 UniProtKB INSD7_ECOLI http://www.uniprot.org/uniprot/INSD7_ECOLI UniProtKB-AC P0CF59 http://www.uniprot.org/uniprot/P0CF59 charge swissprot:INSD7_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSD7_ECOLI eggNOG ENOG4108MVM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MVM eggNOG ENOG410Z4Y8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Z4Y8 epestfind swissprot:INSD7_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSD7_ECOLI garnier swissprot:INSD7_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSD7_ECOLI helixturnhelix swissprot:INSD7_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSD7_ECOLI hmoment swissprot:INSD7_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSD7_ECOLI iep swissprot:INSD7_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSD7_ECOLI inforesidue swissprot:INSD7_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSD7_ECOLI octanol swissprot:INSD7_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSD7_ECOLI pepcoil swissprot:INSD7_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSD7_ECOLI pepdigest swissprot:INSD7_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSD7_ECOLI pepinfo swissprot:INSD7_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSD7_ECOLI pepnet swissprot:INSD7_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSD7_ECOLI pepstats swissprot:INSD7_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSD7_ECOLI pepwheel swissprot:INSD7_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSD7_ECOLI pepwindow swissprot:INSD7_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSD7_ECOLI sigcleave swissprot:INSD7_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSD7_ECOLI ## Database ID URL or Descriptions # BioGrid 4263219 114 # DISRUPTION PHENOTYPE Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain. {ECO:0000269|PubMed 20345943}. # EcoGene EG13882 sfmC # FUNCTION SFMC_ECOLI Part of the sfmACDHF fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes. {ECO 0000269|PubMed 20345943}. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IEA:InterPro. # GO_function GO:0044183 protein binding involved in protein folding; IBA:GO_Central. # GO_process GO:0043711 pilus organization; IBA:GO_Central. # GO_process GO:0061077 chaperone-mediated protein folding; IBA:GO_Central. # GO_process GO:0071555 cell wall organization; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006457 protein folding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 2.60.40.1070 -; 1. # Gene3D 2.60.40.360 -; 1. # INDUCTION Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression. {ECO:0000269|PubMed 20345943}. # IntAct P77249 3 # InterPro IPR001829 Pili_assmbl_chaperone_bac # InterPro IPR008962 PapD-like # InterPro IPR016147 Pili_assmbl_chaperone_N # InterPro IPR016148 Pili_assmbl_chaperone_C # InterPro IPR018046 Pili_assmbl_chaperone_CS # KEGG_Brite ko02035 Bacterial motility proteins # MISCELLANEOUS The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed. {ECO:0000305|PubMed 20345943}. # Organism SFMC_ECOLI Escherichia coli (strain K12) # PATRIC 32116222 VBIEscCol129921_0552 # PIR B64785 B64785 # PRINTS PR00969 CHAPERONPILI # PROSITE PS00635 PILI_CHAPERONE # Pfam PF00345 PapD_N # Pfam PF02753 PapD_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SFMC_ECOLI Probable fimbrial chaperone SfmC # RefSeq NP_415064 NC_000913.3 # RefSeq WP_000988364 NZ_LN832404.1 # SIMILARITY Belongs to the periplasmic pilus chaperone family. {ECO 0000305}. # SIMILARITY Contains 1 Ig-like (immunoglobulin-like) domain. {ECO 0000305}. # SUBCELLULAR LOCATION SFMC_ECOLI Periplasm {ECO 0000305}. # SUPFAM SSF49354 SSF49354 # SUPFAM SSF49584 SSF49584 # eggNOG ENOG4108AF8 Bacteria # eggNOG ENOG410ZPTT LUCA BLAST swissprot:SFMC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SFMC_ECOLI BioCyc ECOL316407:JW0520-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0520-MONOMER BioCyc EcoCyc:G6291-MONOMER http://biocyc.org/getid?id=EcoCyc:G6291-MONOMER COG COG3121 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3121 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1462-2920.2010.02202.x http://dx.doi.org/10.1111/j.1462-2920.2010.02202.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EchoBASE EB3641 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3641 EcoGene EG13882 http://www.ecogene.org/geneInfo.php?eg_id=EG13882 EnsemblBacteria AAC73633 http://www.ensemblgenomes.org/id/AAC73633 EnsemblBacteria AAC73633 http://www.ensemblgenomes.org/id/AAC73633 EnsemblBacteria BAE76308 http://www.ensemblgenomes.org/id/BAE76308 EnsemblBacteria BAE76308 http://www.ensemblgenomes.org/id/BAE76308 EnsemblBacteria BAE76308 http://www.ensemblgenomes.org/id/BAE76308 EnsemblBacteria b0531 http://www.ensemblgenomes.org/id/b0531 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0044183 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044183 GO_process GO:0043711 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043711 GO_process GO:0061077 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061077 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 2.60.40.1070 http://www.cathdb.info/version/latest/superfamily/2.60.40.1070 Gene3D 2.60.40.360 http://www.cathdb.info/version/latest/superfamily/2.60.40.360 GeneID 945367 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945367 HOGENOM HOG000260152 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260152&db=HOGENOM6 IntAct P77249 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77249* InterPro IPR001829 http://www.ebi.ac.uk/interpro/entry/IPR001829 InterPro IPR008962 http://www.ebi.ac.uk/interpro/entry/IPR008962 InterPro IPR016147 http://www.ebi.ac.uk/interpro/entry/IPR016147 InterPro IPR016148 http://www.ebi.ac.uk/interpro/entry/IPR016148 InterPro IPR018046 http://www.ebi.ac.uk/interpro/entry/IPR018046 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW0520 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0520 KEGG_Gene eco:b0531 http://www.genome.jp/dbget-bin/www_bget?eco:b0531 KEGG_Orthology KO:K07353 http://www.genome.jp/dbget-bin/www_bget?KO:K07353 OMA MIAPKNS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MIAPKNS PRINTS PR00969 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00969 PROSITE PS00635 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00635 PSORT swissprot:SFMC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SFMC_ECOLI PSORT-B swissprot:SFMC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SFMC_ECOLI PSORT2 swissprot:SFMC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SFMC_ECOLI Pfam PF00345 http://pfam.xfam.org/family/PF00345 Pfam PF02753 http://pfam.xfam.org/family/PF02753 Phobius swissprot:SFMC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SFMC_ECOLI PhylomeDB P77249 http://phylomedb.org/?seqid=P77249 ProteinModelPortal P77249 http://www.proteinmodelportal.org/query/uniprot/P77249 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20345943 http://www.ncbi.nlm.nih.gov/pubmed/20345943 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415064 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415064 RefSeq WP_000988364 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000988364 STRING 511145.b0531 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0531&targetmode=cogs STRING COG3121 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3121&targetmode=cogs SUPFAM SSF49354 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49354 SUPFAM SSF49584 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49584 UniProtKB SFMC_ECOLI http://www.uniprot.org/uniprot/SFMC_ECOLI UniProtKB-AC P77249 http://www.uniprot.org/uniprot/P77249 charge swissprot:SFMC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SFMC_ECOLI eggNOG ENOG4108AF8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108AF8 eggNOG ENOG410ZPTT http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZPTT epestfind swissprot:SFMC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SFMC_ECOLI garnier swissprot:SFMC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SFMC_ECOLI helixturnhelix swissprot:SFMC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SFMC_ECOLI hmoment swissprot:SFMC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SFMC_ECOLI iep swissprot:SFMC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SFMC_ECOLI inforesidue swissprot:SFMC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SFMC_ECOLI octanol swissprot:SFMC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SFMC_ECOLI pepcoil swissprot:SFMC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SFMC_ECOLI pepdigest swissprot:SFMC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SFMC_ECOLI pepinfo swissprot:SFMC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SFMC_ECOLI pepnet swissprot:SFMC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SFMC_ECOLI pepstats swissprot:SFMC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SFMC_ECOLI pepwheel swissprot:SFMC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SFMC_ECOLI pepwindow swissprot:SFMC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SFMC_ECOLI sigcleave swissprot:SFMC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SFMC_ECOLI ## Database ID URL or Descriptions # BioGrid 4259922 240 # EcoGene EG13307 ybgK # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # Gene3D 2.40.100.10 -; 1. # IntAct P75745 6 # InterPro IPR003778 CT_A_B # InterPro IPR029000 Cyclophilin-like_dom # Organism YBGK_ECOLI Escherichia coli (strain K12) # PATRIC 32116619 VBIEscCol129921_0742 # PDB 5DUD X-ray; 2.80 A; A/C=1-310 # PIR G64806 G64806 # Pfam PF02626 CT_A_B # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBGK_ECOLI Uncharacterized protein YbgK # RefSeq NP_415240 NC_000913.3 # RefSeq WP_000912724 NZ_LN832404.1 # SIMILARITY To B.subtilis YcsJ and yeast urea amidolyase (DUR1,2). {ECO 0000305}. # SIMILARITY To H.influenzae HI_1730. {ECO 0000305}. # SMART SM00797 AHS2 # SUPFAM SSF50891 SSF50891 # TIGRFAMs TIGR00724 urea_amlyse_rel # eggNOG COG1984 LUCA # eggNOG ENOG4107R7A Bacteria BLAST swissprot:YBGK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBGK_ECOLI BioCyc ECOL316407:JW0702-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0702-MONOMER BioCyc EcoCyc:G6381-MONOMER http://biocyc.org/getid?id=EcoCyc:G6381-MONOMER DIP DIP-11397N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11397N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3091 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3091 EcoGene EG13307 http://www.ecogene.org/geneInfo.php?eg_id=EG13307 EnsemblBacteria AAC73806 http://www.ensemblgenomes.org/id/AAC73806 EnsemblBacteria AAC73806 http://www.ensemblgenomes.org/id/AAC73806 EnsemblBacteria BAA35376 http://www.ensemblgenomes.org/id/BAA35376 EnsemblBacteria BAA35376 http://www.ensemblgenomes.org/id/BAA35376 EnsemblBacteria BAA35376 http://www.ensemblgenomes.org/id/BAA35376 EnsemblBacteria b0712 http://www.ensemblgenomes.org/id/b0712 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 Gene3D 2.40.100.10 http://www.cathdb.info/version/latest/superfamily/2.40.100.10 GeneID 945317 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945317 HOGENOM HOG000236167 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000236167&db=HOGENOM6 InParanoid P75745 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75745 IntAct P75745 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75745* InterPro IPR003778 http://www.ebi.ac.uk/interpro/entry/IPR003778 InterPro IPR029000 http://www.ebi.ac.uk/interpro/entry/IPR029000 KEGG_Gene ecj:JW0702 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0702 KEGG_Gene eco:b0712 http://www.genome.jp/dbget-bin/www_bget?eco:b0712 OMA QDLGRSH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QDLGRSH PDB 5DUD http://www.ebi.ac.uk/pdbe-srv/view/entry/5DUD PDBsum 5DUD http://www.ebi.ac.uk/pdbsum/5DUD PSORT swissprot:YBGK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBGK_ECOLI PSORT-B swissprot:YBGK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBGK_ECOLI PSORT2 swissprot:YBGK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBGK_ECOLI Pfam PF02626 http://pfam.xfam.org/family/PF02626 Phobius swissprot:YBGK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBGK_ECOLI PhylomeDB P75745 http://phylomedb.org/?seqid=P75745 ProteinModelPortal P75745 http://www.proteinmodelportal.org/query/uniprot/P75745 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415240 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415240 RefSeq WP_000912724 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000912724 SMART SM00797 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00797 SMR P75745 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75745 STRING 511145.b0712 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0712&targetmode=cogs SUPFAM SSF50891 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50891 TIGRFAMs TIGR00724 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00724 UniProtKB YBGK_ECOLI http://www.uniprot.org/uniprot/YBGK_ECOLI UniProtKB-AC P75745 http://www.uniprot.org/uniprot/P75745 charge swissprot:YBGK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBGK_ECOLI eggNOG COG1984 http://eggnogapi.embl.de/nog_data/html/tree/COG1984 eggNOG ENOG4107R7A http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107R7A epestfind swissprot:YBGK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBGK_ECOLI garnier swissprot:YBGK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBGK_ECOLI helixturnhelix swissprot:YBGK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBGK_ECOLI hmoment swissprot:YBGK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBGK_ECOLI iep swissprot:YBGK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBGK_ECOLI inforesidue swissprot:YBGK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBGK_ECOLI octanol swissprot:YBGK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBGK_ECOLI pepcoil swissprot:YBGK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBGK_ECOLI pepdigest swissprot:YBGK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBGK_ECOLI pepinfo swissprot:YBGK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBGK_ECOLI pepnet swissprot:YBGK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBGK_ECOLI pepstats swissprot:YBGK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBGK_ECOLI pepwheel swissprot:YBGK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBGK_ECOLI pepwindow swissprot:YBGK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBGK_ECOLI sigcleave swissprot:YBGK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBGK_ECOLI ## Database ID URL or Descriptions # AltName HIPA_ECOLI Toxin HipA # BioGrid 4260220 11 # CATALYTIC ACTIVITY ATP + a protein = ADP + a phosphoprotein. {ECO:0000269|PubMed 19150849}. # CAUTION HIPA_ECOLI Has been reported to phosphorylate EF-Tu in vitro (on 'Thr-383') (PubMed 19150849). According to another report, does not phosphorylate EF-Tu (PubMed 19622872). {ECO 0000305|PubMed 19150849, ECO 0000305|PubMed 19622872}. # DISRUPTION PHENOTYPE Cells lacking hipA or the hipBA operon cannot produce persister cells at a high frequency. {ECO:0000269|PubMed 8021189}. # ENZYME REGULATION Once phosphorylated no longer has kinase activity. {ECO:0000269|PubMed 22999936}. # EcoGene EG10443 hipA # FUNCTION HIPA_ECOLI Toxic component of a toxin-antitoxin (TA) module. Phosphorylates Glu-tRNA-ligase (GltX, on 'Ser-239') in vivo. Phosphorylation of GltX prevents it from being charged, leading to an increase in uncharged tRNA(Glu). This induces amino acid starvation and the stringent response via RelA/SpoT and increased ppGpp levels, which inhibits replication, transcription, translation and cell wall synthesis, reducing growth and leading to multidrug resistance and persistence. The hipA7 mutation (a double G22S D291A mutation) leads to increased generation of persister cells, cells that survive antibiotic treatment probably by entering into a dormant state. Wild-type cells produce persisters at a frequency of 10(-6) to 10(-5) whereas mutant hipA7 cells produce persisters at a frequency of 10(-2). Generation of persister cells requires ppGpp as cells lacking relA or relA/spoT generate fewer or no persister cells respectively compared to hipA7. Low level expression of HipA induces dormancy and depending on the protein level, can be toxic enough to reduce cell growth or even kill cells. Low levels of wild-type HipA lead to high beta- lactam antibiotic tolerance of the survivor cells, also dependent on relA and relA/spoT. The toxic effect of HipA is neutralized by its cognate antitoxin HipB. With HipB acts as a corepressor for transcription of the hipBA promoter; binding to DNA induces a 70 degree bend. {ECO 0000269|PubMed 14622409, ECO 0000269|PubMed 16707675, ECO 0000269|PubMed 17041039, ECO 0000269|PubMed 19150849, ECO 0000269|PubMed 23667235, ECO 0000269|PubMed 24095282, ECO 0000269|PubMed 6348026, ECO 0000269|PubMed 8021189}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004674 protein serine/threonine kinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IDA:EcoCyc. # GO_process GO:0022611 dormancy process; IDA:EcoCyc. # GO_process GO:0036289 peptidyl-serine autophosphorylation; IDA:EcoCyc. # GO_process GO:0043086 negative regulation of catalytic activity; IDA:EcoCyc. # GO_process GO:0044010 single-species biofilm formation; IMP:EcoCyc. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0008150 biological_process # IntAct P23874 4 # InterPro IPR012893 HipA-like_C # InterPro IPR012894 HipA_N2 # InterPro IPR017508 HipA_N1 # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01001 Protein kinases # MASS SPECTROMETRY Mass=49143.80; Method=MALDI; Range=1-440; Evidence={ECO:0000269|PubMed 24095282}; # MASS SPECTROMETRY Mass=49223.80; Method=MALDI; Range=1-440; Note=Phosphorylated form.; Evidence={ECO:0000269|PubMed 24095282}; # Organism HIPA_ECOLI Escherichia coli (strain K12) # PATRIC 32118308 VBIEscCol129921_1574 # PDB 2WIU X-ray; 2.35 A; A/C=1-440 # PDB 3DNT X-ray; 1.66 A; A/B=1-440 # PDB 3DNU X-ray; 1.54 A; A=1-440 # PDB 3DNV X-ray; 2.68 A; A=1-440 # PDB 3FBR X-ray; 3.50 A; A=1-437 # PDB 3HZI X-ray; 2.98 A; A=1-440 # PDB 3TPB X-ray; 1.88 A; A=1-440 # PDB 3TPD X-ray; 1.50 A; A=1-440 # PDB 3TPE X-ray; 1.90 A; A=1-440 # PDB 3TPT X-ray; 2.25 A; A/B=1-440 # PDB 3TPV X-ray; 2.30 A; B=1-440 # PDB 4YG7 X-ray; 3.77 A; D/K=2-437 # PDB 5K98 X-ray; 3.99 A; A/D=2-440 # PIR F64904 F64904 # PTM HIPA_ECOLI Autophosphorylates intermolecularly on Ser-150; phosphorylated form not seen to bind ATP and no longer has kinase activity. {ECO 0000269|PubMed 17041039, ECO 0000269|PubMed 22999936}. # Pfam PF07804 HipA_C # Pfam PF07805 HipA_N # Pfam PF13657 Couple_hipA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HIPA_ECOLI Serine/threonine-protein kinase HipA # RefSeq NP_416024 NC_000913.3 # RefSeq WP_001125439 NZ_CP014272.1 # SIMILARITY Belongs to the HipA Ser/Thr kinase family. {ECO 0000305}. # SUBUNIT HIPA_ECOLI Forms a HipA(2)HipB(2) heterotetramer which can interact with DNA. {ECO 0000269|PubMed 19150849, ECO 0000269|PubMed 19622872, ECO 0000269|PubMed 22999936, ECO 0000269|PubMed 24089363, ECO 0000269|PubMed 24095282}. # TIGRFAMs TIGR03071 couple_hipA # eggNOG COG3550 LUCA # eggNOG ENOG4105CAF Bacteria BLAST swissprot:HIPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HIPA_ECOLI BioCyc ECOL316407:JW1500-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1500-MONOMER BioCyc EcoCyc:EG10443-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10443-MONOMER BioCyc MetaCyc:EG10443-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10443-MONOMER COG COG3550 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3550 DIP DIP-9898N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9898N DOI 10.1002/jmr.2300 http://dx.doi.org/10.1002/jmr.2300 DOI 10.1016/j.celrep.2012.08.013 http://dx.doi.org/10.1016/j.celrep.2012.08.013 DOI 10.1016/j.molcel.2013.08.045 http://dx.doi.org/10.1016/j.molcel.2013.08.045 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2003.03779.x http://dx.doi.org/10.1046/j.1365-2958.2003.03779.x DOI 10.1107/S0907444909018800 http://dx.doi.org/10.1107/S0907444909018800 DOI 10.1126/science.1163806 http://dx.doi.org/10.1126/science.1163806 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01237-06 http://dx.doi.org/10.1128/JB.01237-06 DOI 10.1128/JB.01740-05 http://dx.doi.org/10.1128/JB.01740-05 DOI 10.1128/JB.02210-12 http://dx.doi.org/10.1128/JB.02210-12 EC_number EC:2.7.11.1 {ECO:0000269|PubMed:19150849} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.11.1 {ECO:0000269|PubMed:19150849} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M61242 http://www.ebi.ac.uk/ena/data/view/M61242 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.11.1 {ECO:0000269|PubMed:19150849} http://enzyme.expasy.org/EC/2.7.11.1 {ECO:0000269|PubMed:19150849} EchoBASE EB0438 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0438 EcoGene EG10443 http://www.ecogene.org/geneInfo.php?eg_id=EG10443 EnsemblBacteria AAC74580 http://www.ensemblgenomes.org/id/AAC74580 EnsemblBacteria AAC74580 http://www.ensemblgenomes.org/id/AAC74580 EnsemblBacteria BAA15179 http://www.ensemblgenomes.org/id/BAA15179 EnsemblBacteria BAA15179 http://www.ensemblgenomes.org/id/BAA15179 EnsemblBacteria BAA15179 http://www.ensemblgenomes.org/id/BAA15179 EnsemblBacteria b1507 http://www.ensemblgenomes.org/id/b1507 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004674 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0022611 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022611 GO_process GO:0036289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036289 GO_process GO:0043086 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043086 GO_process GO:0044010 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044010 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 946064 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946064 HOGENOM HOG000188799 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000188799&db=HOGENOM6 InParanoid P23874 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23874 IntAct P23874 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P23874* IntEnz 2.7.11.1 {ECO:0000269|PubMed:19150849} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.11.1 {ECO:0000269|PubMed:19150849} InterPro IPR012893 http://www.ebi.ac.uk/interpro/entry/IPR012893 InterPro IPR012894 http://www.ebi.ac.uk/interpro/entry/IPR012894 InterPro IPR017508 http://www.ebi.ac.uk/interpro/entry/IPR017508 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01001 http://www.genome.jp/dbget-bin/www_bget?ko01001 KEGG_Gene ecj:JW1500 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1500 KEGG_Gene eco:b1507 http://www.genome.jp/dbget-bin/www_bget?eco:b1507 KEGG_Orthology KO:K07154 http://www.genome.jp/dbget-bin/www_bget?KO:K07154 MINT MINT-1292260 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1292260 OMA SCENEWL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SCENEWL PDB 2WIU http://www.ebi.ac.uk/pdbe-srv/view/entry/2WIU PDB 3DNT http://www.ebi.ac.uk/pdbe-srv/view/entry/3DNT PDB 3DNU http://www.ebi.ac.uk/pdbe-srv/view/entry/3DNU PDB 3DNV http://www.ebi.ac.uk/pdbe-srv/view/entry/3DNV PDB 3FBR http://www.ebi.ac.uk/pdbe-srv/view/entry/3FBR PDB 3HZI http://www.ebi.ac.uk/pdbe-srv/view/entry/3HZI PDB 3TPB http://www.ebi.ac.uk/pdbe-srv/view/entry/3TPB PDB 3TPD http://www.ebi.ac.uk/pdbe-srv/view/entry/3TPD PDB 3TPE http://www.ebi.ac.uk/pdbe-srv/view/entry/3TPE PDB 3TPT http://www.ebi.ac.uk/pdbe-srv/view/entry/3TPT PDB 3TPV http://www.ebi.ac.uk/pdbe-srv/view/entry/3TPV PDB 4YG7 http://www.ebi.ac.uk/pdbe-srv/view/entry/4YG7 PDB 5K98 http://www.ebi.ac.uk/pdbe-srv/view/entry/5K98 PDBsum 2WIU http://www.ebi.ac.uk/pdbsum/2WIU PDBsum 3DNT http://www.ebi.ac.uk/pdbsum/3DNT PDBsum 3DNU http://www.ebi.ac.uk/pdbsum/3DNU PDBsum 3DNV http://www.ebi.ac.uk/pdbsum/3DNV PDBsum 3FBR http://www.ebi.ac.uk/pdbsum/3FBR PDBsum 3HZI http://www.ebi.ac.uk/pdbsum/3HZI PDBsum 3TPB http://www.ebi.ac.uk/pdbsum/3TPB PDBsum 3TPD http://www.ebi.ac.uk/pdbsum/3TPD PDBsum 3TPE http://www.ebi.ac.uk/pdbsum/3TPE PDBsum 3TPT http://www.ebi.ac.uk/pdbsum/3TPT PDBsum 3TPV http://www.ebi.ac.uk/pdbsum/3TPV PDBsum 4YG7 http://www.ebi.ac.uk/pdbsum/4YG7 PDBsum 5K98 http://www.ebi.ac.uk/pdbsum/5K98 PSORT swissprot:HIPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HIPA_ECOLI PSORT-B swissprot:HIPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HIPA_ECOLI PSORT2 swissprot:HIPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HIPA_ECOLI Pfam PF07804 http://pfam.xfam.org/family/PF07804 Pfam PF07805 http://pfam.xfam.org/family/PF07805 Pfam PF13657 http://pfam.xfam.org/family/PF13657 Phobius swissprot:HIPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HIPA_ECOLI ProteinModelPortal P23874 http://www.proteinmodelportal.org/query/uniprot/P23874 PubMed 14622409 http://www.ncbi.nlm.nih.gov/pubmed/14622409 PubMed 16707675 http://www.ncbi.nlm.nih.gov/pubmed/16707675 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17041039 http://www.ncbi.nlm.nih.gov/pubmed/17041039 PubMed 1715862 http://www.ncbi.nlm.nih.gov/pubmed/1715862 PubMed 19150849 http://www.ncbi.nlm.nih.gov/pubmed/19150849 PubMed 19622872 http://www.ncbi.nlm.nih.gov/pubmed/19622872 PubMed 22999936 http://www.ncbi.nlm.nih.gov/pubmed/22999936 PubMed 23667235 http://www.ncbi.nlm.nih.gov/pubmed/23667235 PubMed 24089363 http://www.ncbi.nlm.nih.gov/pubmed/24089363 PubMed 24095282 http://www.ncbi.nlm.nih.gov/pubmed/24095282 PubMed 6348026 http://www.ncbi.nlm.nih.gov/pubmed/6348026 PubMed 8021189 http://www.ncbi.nlm.nih.gov/pubmed/8021189 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416024 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416024 RefSeq WP_001125439 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001125439 SMR P23874 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P23874 STRING 511145.b1507 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1507&targetmode=cogs STRING COG3550 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3550&targetmode=cogs TIGRFAMs TIGR03071 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03071 UniProtKB HIPA_ECOLI http://www.uniprot.org/uniprot/HIPA_ECOLI UniProtKB-AC P23874 http://www.uniprot.org/uniprot/P23874 charge swissprot:HIPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HIPA_ECOLI eggNOG COG3550 http://eggnogapi.embl.de/nog_data/html/tree/COG3550 eggNOG ENOG4105CAF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CAF epestfind swissprot:HIPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HIPA_ECOLI garnier swissprot:HIPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HIPA_ECOLI helixturnhelix swissprot:HIPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HIPA_ECOLI hmoment swissprot:HIPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HIPA_ECOLI iep swissprot:HIPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HIPA_ECOLI inforesidue swissprot:HIPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HIPA_ECOLI octanol swissprot:HIPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HIPA_ECOLI pepcoil swissprot:HIPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HIPA_ECOLI pepdigest swissprot:HIPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HIPA_ECOLI pepinfo swissprot:HIPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HIPA_ECOLI pepnet swissprot:HIPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HIPA_ECOLI pepstats swissprot:HIPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HIPA_ECOLI pepwheel swissprot:HIPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HIPA_ECOLI pepwindow swissprot:HIPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HIPA_ECOLI sigcleave swissprot:HIPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HIPA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260106 4 # COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI 18420; Evidence={ECO:0000250}; # ENZYME REGULATION ATPase activity is stimulated by potassium and other monovalent cations. Stimulation is maximal in the presence of K(+), followed by NH(4)(+), Rb(+), Na(+) and Cs(+). {ECO:0000269|PubMed 21527254}. # EcoGene EG11404 ychF # FUNCTION YCHF_ECOLI ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. Does not hydrolyze GTP. {ECO 0000255|HAMAP-Rule MF_00944, ECO 0000269|PubMed 21527254}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0004857 enzyme inhibitor activity; IMP:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0005525 GTP binding; IEA:InterPro. # GO_function GO:0016887 ATPase activity; IDA:EcoCyc. # GO_function GO:0043022 ribosome binding; IDA:EcoCyc. # GO_function GO:0043023 ribosomal large subunit binding; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006979 response to oxidative stress; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0030234 enzyme regulator activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # Gene3D 1.10.150.300 -; 1. # Gene3D 3.10.20.30 -; 1. # Gene3D 3.40.50.300 -; 2. # HAMAP MF_00944 YchF_OLA1_ATPase # IntAct P0ABU2 6 # InterPro IPR004396 ATPase_YchF/OLA1 # InterPro IPR006073 GTP_binding_domain # InterPro IPR012675 Beta-grasp_dom # InterPro IPR012676 TGS-like # InterPro IPR013029 DUF933 # InterPro IPR023192 TGS-like_dom # InterPro IPR027417 P-loop_NTPase # InterPro IPR031167 G_OBG # Organism YCHF_ECOLI Escherichia coli (strain K12) # PATRIC 32117658 VBIEscCol129921_1251 # PIR H64866 H64866 # PIRSF PIRSF006641 CHP00092 # PRINTS PR00326 GTP1OBG # PROSITE PS51710 G_OBG # Pfam PF01926 MMR_HSR1 # Pfam PF06071 YchF-GTPase_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Ribosome-binding ATPase YchF {ECO:0000255|HAMAP-Rule MF_00944} # RefSeq NP_415721 NC_000913.3 # RefSeq WP_000505866 NZ_LN832404.1 # SIMILARITY Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily. {ECO:0000255|HAMAP-Rule MF_00944}. # SIMILARITY Contains 1 OBG-type G (guanine nucleotide-binding) domain. {ECO 0000305}. # SUBUNIT Monomer. {ECO:0000269|PubMed 21527254}. # SUPFAM SSF52540 SSF52540 # SUPFAM SSF81271 SSF81271 # TIGRFAMs TIGR00092 TIGR00092 # eggNOG COG0012 LUCA # eggNOG ENOG4105C3G Bacteria BLAST swissprot:YCHF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCHF_ECOLI BioCyc ECOL316407:JW1194-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1194-MONOMER BioCyc EcoCyc:EG11404-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11404-MONOMER BioCyc MetaCyc:EG11404-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11404-MONOMER COG COG0012 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0012 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1016/0378-1119(94)90647-5 http://dx.doi.org/10.1016/0378-1119(94)90647-5 DOI 10.1016/j.bbrc.2011.04.052 http://dx.doi.org/10.1016/j.bbrc.2011.04.052 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U02423 http://www.ebi.ac.uk/ena/data/view/U02423 EMBL X61941 http://www.ebi.ac.uk/ena/data/view/X61941 EchoBASE EB1376 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1376 EcoGene EG11404 http://www.ecogene.org/geneInfo.php?eg_id=EG11404 EnsemblBacteria AAC74287 http://www.ensemblgenomes.org/id/AAC74287 EnsemblBacteria AAC74287 http://www.ensemblgenomes.org/id/AAC74287 EnsemblBacteria BAA36061 http://www.ensemblgenomes.org/id/BAA36061 EnsemblBacteria BAA36061 http://www.ensemblgenomes.org/id/BAA36061 EnsemblBacteria BAA36061 http://www.ensemblgenomes.org/id/BAA36061 EnsemblBacteria b1203 http://www.ensemblgenomes.org/id/b1203 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004857 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_function GO:0043022 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043022 GO_function GO:0043023 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043023 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 1.10.150.300 http://www.cathdb.info/version/latest/superfamily/1.10.150.300 Gene3D 3.10.20.30 http://www.cathdb.info/version/latest/superfamily/3.10.20.30 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945769 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945769 HAMAP MF_00944 http://hamap.expasy.org/unirule/MF_00944 HOGENOM HOG000087629 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000087629&db=HOGENOM6 InParanoid P0ABU2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABU2 IntAct P0ABU2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABU2* InterPro IPR004396 http://www.ebi.ac.uk/interpro/entry/IPR004396 InterPro IPR006073 http://www.ebi.ac.uk/interpro/entry/IPR006073 InterPro IPR012675 http://www.ebi.ac.uk/interpro/entry/IPR012675 InterPro IPR012676 http://www.ebi.ac.uk/interpro/entry/IPR012676 InterPro IPR013029 http://www.ebi.ac.uk/interpro/entry/IPR013029 InterPro IPR023192 http://www.ebi.ac.uk/interpro/entry/IPR023192 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR031167 http://www.ebi.ac.uk/interpro/entry/IPR031167 KEGG_Gene ecj:JW1194 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1194 KEGG_Gene eco:b1203 http://www.genome.jp/dbget-bin/www_bget?eco:b1203 KEGG_Orthology KO:K06942 http://www.genome.jp/dbget-bin/www_bget?KO:K06942 OMA CTIEPNI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CTIEPNI PRINTS PR00326 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00326 PROSITE PS51710 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51710 PSORT swissprot:YCHF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCHF_ECOLI PSORT-B swissprot:YCHF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCHF_ECOLI PSORT2 swissprot:YCHF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCHF_ECOLI Pfam PF01926 http://pfam.xfam.org/family/PF01926 Pfam PF06071 http://pfam.xfam.org/family/PF06071 Phobius swissprot:YCHF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCHF_ECOLI PhylomeDB P0ABU2 http://phylomedb.org/?seqid=P0ABU2 ProteinModelPortal P0ABU2 http://www.proteinmodelportal.org/query/uniprot/P0ABU2 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1833189 http://www.ncbi.nlm.nih.gov/pubmed/1833189 PubMed 21527254 http://www.ncbi.nlm.nih.gov/pubmed/21527254 PubMed 7828865 http://www.ncbi.nlm.nih.gov/pubmed/7828865 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_415721 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415721 RefSeq WP_000505866 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000505866 SMR P0ABU2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABU2 STRING 511145.b1203 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1203&targetmode=cogs STRING COG0012 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0012&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SUPFAM SSF81271 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81271 SWISS-2DPAGE P0ABU2 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0ABU2 TIGRFAMs TIGR00092 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00092 UniProtKB YCHF_ECOLI http://www.uniprot.org/uniprot/YCHF_ECOLI UniProtKB-AC P0ABU2 http://www.uniprot.org/uniprot/P0ABU2 charge swissprot:YCHF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCHF_ECOLI eggNOG COG0012 http://eggnogapi.embl.de/nog_data/html/tree/COG0012 eggNOG ENOG4105C3G http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C3G epestfind swissprot:YCHF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCHF_ECOLI garnier swissprot:YCHF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCHF_ECOLI helixturnhelix swissprot:YCHF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCHF_ECOLI hmoment swissprot:YCHF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCHF_ECOLI iep swissprot:YCHF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCHF_ECOLI inforesidue swissprot:YCHF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCHF_ECOLI octanol swissprot:YCHF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCHF_ECOLI pepcoil swissprot:YCHF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCHF_ECOLI pepdigest swissprot:YCHF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCHF_ECOLI pepinfo swissprot:YCHF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCHF_ECOLI pepnet swissprot:YCHF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCHF_ECOLI pepstats swissprot:YCHF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCHF_ECOLI pepwheel swissprot:YCHF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCHF_ECOLI pepwindow swissprot:YCHF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCHF_ECOLI sigcleave swissprot:YCHF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCHF_ECOLI ## Database ID URL or Descriptions # AltName ERA_ECOLI GTP-binding protein Era # BIOPHYSICOCHEMICAL PROPERTIES ERA_ECOLI Kinetic parameters KM=15.4 uM for GTP (for His-tagged protein at pH 8.0, 5 mM MgCl(2)) {ECO 0000269|PubMed 2105934, ECO 0000269|PubMed 8919456}; KM=9.0 uM for GTP (for overexpressed protein at pH 8.0, 5 mM MgCl(2)) {ECO 0000269|PubMed 2105934, ECO 0000269|PubMed 8919456}; # BioGrid 4263220 444 # CDD cd04163 Era # DISRUPTION PHENOTYPE ERA_ECOLI Lethality. In the presence of 1% protein cells grow extremely slowly and are blocked at the predivisional two-cell stage of the cell cycle. In the absence of Era and Rnc there is an additional defect in chromosome partitioning. In depletion experiments cells grow normally for 2 hours when protein levels fall. After 4 hours 16S rRNA levels decrease with a concomitant rise in the 17S precursor rRNA molecule (extra sequences at both the 5' and 3' end compared to mature 16S rRNA) and a loss of 70S ribosome assembly. {ECO 0000269|PubMed 2527846, ECO 0000269|PubMed 2540151, ECO 0000269|PubMed 9515700}. # ENZYME REGULATION GTPase is competitively inhibited by GDP but not by ADP, ATP, CTP or UTP. {ECO:0000269|PubMed 2105934}. # EcoGene EG10270 era # FUNCTION ERA_ECOLI An essential GTPase that binds both GDP and GTP, with nucleotide exchange occurring on the order of seconds whereas hydrolysis occurs on the order of minutes. Plays a role in numerous processes, including cell cycle regulation, energy metabolism, as a chaperone for 16S rRNA processing and 30S ribosomal subunit biogenesis. Its presence in the 30S subunit may prevent translation initiation. Seems to be critical for maintaining cell growth and cell divison rates; a dramatic reduction in Era protein levels temporarily arrests cell growth just before cytokinesis (at the predivisional two-cell stage) and delays cell division. Era mutant era1 suppresses some temperature- sensitive mutations that affect DNA replication and chromosome partitioning and segregation. The dominant-negative Era-de mutant which is missing residues in a putative effector region, is unable to complement the disruption mutant; upon overproduction it shows a significant decrease in cell viability and a synthetic lethal phenotype in the presence of acetate. Era function probably overlaps RbfA. Binds to the pre-30S subunit through several stages of protein assembly. {ECO 0000269|PubMed 12753192, ECO 0000269|PubMed 16825789, ECO 0000269|PubMed 20188109, ECO 0000269|PubMed 9515700}. # GO_component GO:0005737 cytoplasm; TAS:UniProtKB. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005886 plasma membrane; IDA:UniProtKB. # GO_function GO:0003924 GTPase activity; IDA:UniProtKB. # GO_function GO:0005525 GTP binding; IDA:UniProtKB. # GO_function GO:0043024 ribosomal small subunit binding; IDA:UniProtKB. # GO_function GO:0070181 small ribosomal subunit rRNA binding; IDA:UniProtKB. # GO_process GO:0000028 ribosomal small subunit assembly; IBA:GO_Central. # GO_process GO:0006468 protein phosphorylation; IDA:UniProtKB. # GO_process GO:0042274 ribosomal small subunit biogenesis; IMP:UniProtKB. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003924 GTPase activity # GOslim_function GO:0019843 rRNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0022618 ribonucleoprotein complex assembly # Gene3D 3.30.300.20 -; 1. # Gene3D 3.40.50.300 -; 1. # HAMAP MF_00367 GTPase_Era # INDUCTION Expression increases as the growth rate increases. Encoded in the rnc-era-recO operon. {ECO:0000269|PubMed 9515700}. # IntAct P06616 28 # InterPro IPR004044 KH_dom_type_2 # InterPro IPR005225 Small_GTP-bd_dom # InterPro IPR005662 GTP-bd_Era # InterPro IPR006073 GTP_binding_domain # InterPro IPR009019 KH_prok-type # InterPro IPR015946 KH_dom-like_a/b # InterPro IPR027417 P-loop_NTPase # InterPro IPR030388 G_ERA_dom # KEGG_Brite ko03009 Ribosome biogenesis # MASS SPECTROMETRY Mass=33682; Mass_error=5; Method=Electrospray; Range=2-301; Evidence={ECO:0000269|PubMed 10094501}; # MISCELLANEOUS ERA_ECOLI When overexpressed partially suppresses the slow growth and decreased 70S ribosome phenotype of an rsgA knockout; RsgA may be involved in 30S ribosomal subunit biogenesis. When overexpressed partially suppresses the ribosome assembly defects and cold-sensitivity of an rbfA knockout; an era mutant missing residues 40-49 fully suppresses these phenotypes. RbfA plays a role in 30S ribosomal subunit maturation. Overexpression is not able to suppress a rimM disruption phenotype nor a C23U mutation in 16S rRNA. Also suppresses temperature-sensitive mutations in DNA primase. # Organism ERA_ECOLI Escherichia coli (strain K12) # PATRIC 32120531 VBIEscCol129921_2668 # PDB 1EGA X-ray; 2.40 A; A/B=1-301 # PDB 3IEU X-ray; 2.80 A; A/B=1-301 # PIR S44713 RGECGT # PROSITE PS50823 KH_TYPE_2 # PROSITE PS51713 G_ERA # PTM ERA_ECOLI Autophosphorylated. {ECO 0000269|PubMed 8919456}. # Pfam PF01926 MMR_HSR1 # Pfam PF07650 KH_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ERA_ECOLI GTPase Era # RefSeq NP_417061 NC_000913.3 # RefSeq WP_000020749 NZ_LN832404.1 # SIMILARITY Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. Era GTPase family. {ECO 0000305}. # SIMILARITY Contains 1 Era-type G (guanine nucleotide-binding) domain. {ECO 0000305}. # SIMILARITY Contains 1 KH type-2 domain. {ECO 0000305}. # SUBCELLULAR LOCATION ERA_ECOLI Cytoplasm {ECO 0000269|PubMed 8282709}. Cell inner membrane {ECO 0000269|PubMed 8282709}; Peripheral membrane protein {ECO 0000269|PubMed 8282709}; Cytoplasmic side {ECO 0000269|PubMed 8282709}. Note=Binding is GDP or GTP- dependent, slightly more protein is bound in the presence of GTP than GDP. # SUBUNIT ERA_ECOLI Monomer. Binds both 16S rRNA and 30S ribosomal subunits; binding is inhibited by GDP and GTP. Binds to MazG; GDP-bound Era binds more tightly to MazG than GTP-bound Era. {ECO 0000269|PubMed 10094501, ECO 0000269|PubMed 19706445}. # SUPFAM SSF52540 SSF52540 # SUPFAM SSF54814 SSF54814 # TIGRFAMs TIGR00231 small_GTP # TIGRFAMs TIGR00436 era # eggNOG COG1159 LUCA # eggNOG ENOG4105CWT Bacteria BLAST swissprot:ERA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ERA_ECOLI BioCyc ECOL316407:JW2550-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2550-MONOMER BioCyc EcoCyc:EG10270-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10270-MONOMER COG COG1159 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1159 DIP DIP-9521N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9521N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/bbrc.1999.1471 http://dx.doi.org/10.1006/bbrc.1999.1471 DOI 10.1016/0378-1097(92)90419-O http://dx.doi.org/10.1016/0378-1097(92)90419-O DOI 10.1016/S0014-5793(99)00178-7 http://dx.doi.org/10.1016/S0014-5793(99)00178-7 DOI 10.1016/j.jmb.2010.02.036 http://dx.doi.org/10.1016/j.jmb.2010.02.036 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1998.00719.x http://dx.doi.org/10.1046/j.1365-2958.1998.00719.x DOI 10.1046/j.1365-2958.2003.03475.x http://dx.doi.org/10.1046/j.1365-2958.2003.03475.x DOI 10.1073/pnas.0904032106 http://dx.doi.org/10.1073/pnas.0904032106 DOI 10.1073/pnas.83.23.8849 http://dx.doi.org/10.1073/pnas.83.23.8849 DOI 10.1073/pnas.96.15.8396 http://dx.doi.org/10.1073/pnas.96.15.8396 DOI 10.1093/nar/13.13.4677 http://dx.doi.org/10.1093/nar/13.13.4677 DOI 10.1111/j.1365-2958.1994.tb01009.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb01009.x DOI 10.1111/j.1574-6968.1995.tb07432.x http://dx.doi.org/10.1111/j.1574-6968.1995.tb07432.x DOI 10.1111/j.1574-6968.1996.tb08025.x http://dx.doi.org/10.1111/j.1574-6968.1996.tb08025.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01744-07 http://dx.doi.org/10.1128/JB.01744-07 DOI 10.1128/JB.182.12.3460-3466.2000 http://dx.doi.org/10.1128/JB.182.12.3460-3466.2000 DOI 10.1128/JB.184.19.5323-5329.2002 http://dx.doi.org/10.1128/JB.184.19.5323-5329.2002 DOI 10.1159/000092818 http://dx.doi.org/10.1159/000092818 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D64044 http://www.ebi.ac.uk/ena/data/view/D64044 EMBL M14658 http://www.ebi.ac.uk/ena/data/view/M14658 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36841 http://www.ebi.ac.uk/ena/data/view/U36841 EMBL X02673 http://www.ebi.ac.uk/ena/data/view/X02673 EchoBASE EB0266 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0266 EcoGene EG10270 http://www.ecogene.org/geneInfo.php?eg_id=EG10270 EnsemblBacteria AAC75619 http://www.ensemblgenomes.org/id/AAC75619 EnsemblBacteria AAC75619 http://www.ensemblgenomes.org/id/AAC75619 EnsemblBacteria BAE76742 http://www.ensemblgenomes.org/id/BAE76742 EnsemblBacteria BAE76742 http://www.ensemblgenomes.org/id/BAE76742 EnsemblBacteria BAE76742 http://www.ensemblgenomes.org/id/BAE76742 EnsemblBacteria b2566 http://www.ensemblgenomes.org/id/b2566 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_function GO:0043024 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043024 GO_function GO:0070181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070181 GO_process GO:0000028 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000028 GO_process GO:0006468 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006468 GO_process GO:0042274 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042274 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0022618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022618 Gene3D 3.30.300.20 http://www.cathdb.info/version/latest/superfamily/3.30.300.20 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947036 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947036 HAMAP MF_00367 http://hamap.expasy.org/unirule/MF_00367 HOGENOM HOG000245597 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000245597&db=HOGENOM6 InParanoid P06616 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P06616 IntAct P06616 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P06616* InterPro IPR004044 http://www.ebi.ac.uk/interpro/entry/IPR004044 InterPro IPR005225 http://www.ebi.ac.uk/interpro/entry/IPR005225 InterPro IPR005662 http://www.ebi.ac.uk/interpro/entry/IPR005662 InterPro IPR006073 http://www.ebi.ac.uk/interpro/entry/IPR006073 InterPro IPR009019 http://www.ebi.ac.uk/interpro/entry/IPR009019 InterPro IPR015946 http://www.ebi.ac.uk/interpro/entry/IPR015946 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR030388 http://www.ebi.ac.uk/interpro/entry/IPR030388 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW2550 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2550 KEGG_Gene eco:b2566 http://www.genome.jp/dbget-bin/www_bget?eco:b2566 KEGG_Orthology KO:K03595 http://www.genome.jp/dbget-bin/www_bget?KO:K03595 MINT MINT-1248282 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1248282 OMA KVAKDWQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KVAKDWQ PDB 1EGA http://www.ebi.ac.uk/pdbe-srv/view/entry/1EGA PDB 3IEU http://www.ebi.ac.uk/pdbe-srv/view/entry/3IEU PDBsum 1EGA http://www.ebi.ac.uk/pdbsum/1EGA PDBsum 3IEU http://www.ebi.ac.uk/pdbsum/3IEU PROSITE PS50823 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50823 PROSITE PS51713 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51713 PSORT swissprot:ERA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ERA_ECOLI PSORT-B swissprot:ERA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ERA_ECOLI PSORT2 swissprot:ERA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ERA_ECOLI Pfam PF01926 http://pfam.xfam.org/family/PF01926 Pfam PF07650 http://pfam.xfam.org/family/PF07650 Phobius swissprot:ERA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ERA_ECOLI PhylomeDB P06616 http://phylomedb.org/?seqid=P06616 ProteinModelPortal P06616 http://www.proteinmodelportal.org/query/uniprot/P06616 PubMed 10094501 http://www.ncbi.nlm.nih.gov/pubmed/10094501 PubMed 10411886 http://www.ncbi.nlm.nih.gov/pubmed/10411886 PubMed 10527840 http://www.ncbi.nlm.nih.gov/pubmed/10527840 PubMed 10852878 http://www.ncbi.nlm.nih.gov/pubmed/10852878 PubMed 12125819 http://www.ncbi.nlm.nih.gov/pubmed/12125819 PubMed 12218018 http://www.ncbi.nlm.nih.gov/pubmed/12218018 PubMed 12753192 http://www.ncbi.nlm.nih.gov/pubmed/12753192 PubMed 1526446 http://www.ncbi.nlm.nih.gov/pubmed/1526446 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16825789 http://www.ncbi.nlm.nih.gov/pubmed/16825789 PubMed 18223068 http://www.ncbi.nlm.nih.gov/pubmed/18223068 PubMed 19706445 http://www.ncbi.nlm.nih.gov/pubmed/19706445 PubMed 20188109 http://www.ncbi.nlm.nih.gov/pubmed/20188109 PubMed 2105934 http://www.ncbi.nlm.nih.gov/pubmed/2105934 PubMed 2527846 http://www.ncbi.nlm.nih.gov/pubmed/2527846 PubMed 2540151 http://www.ncbi.nlm.nih.gov/pubmed/2540151 PubMed 3097637 http://www.ncbi.nlm.nih.gov/pubmed/3097637 PubMed 3895158 http://www.ncbi.nlm.nih.gov/pubmed/3895158 PubMed 7729673 http://www.ncbi.nlm.nih.gov/pubmed/7729673 PubMed 8057845 http://www.ncbi.nlm.nih.gov/pubmed/8057845 PubMed 8282709 http://www.ncbi.nlm.nih.gov/pubmed/8282709 PubMed 8919456 http://www.ncbi.nlm.nih.gov/pubmed/8919456 PubMed 9093842 http://www.ncbi.nlm.nih.gov/pubmed/9093842 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9515700 http://www.ncbi.nlm.nih.gov/pubmed/9515700 PubMed 9748462 http://www.ncbi.nlm.nih.gov/pubmed/9748462 RefSeq NP_417061 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417061 RefSeq WP_000020749 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000020749 SMR P06616 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P06616 STRING 511145.b2566 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2566&targetmode=cogs STRING COG1159 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1159&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SUPFAM SSF54814 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54814 TIGRFAMs TIGR00231 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00231 TIGRFAMs TIGR00436 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00436 UniProtKB ERA_ECOLI http://www.uniprot.org/uniprot/ERA_ECOLI UniProtKB-AC P06616 http://www.uniprot.org/uniprot/P06616 charge swissprot:ERA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ERA_ECOLI eggNOG COG1159 http://eggnogapi.embl.de/nog_data/html/tree/COG1159 eggNOG ENOG4105CWT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CWT epestfind swissprot:ERA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ERA_ECOLI garnier swissprot:ERA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ERA_ECOLI helixturnhelix swissprot:ERA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ERA_ECOLI hmoment swissprot:ERA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ERA_ECOLI iep swissprot:ERA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ERA_ECOLI inforesidue swissprot:ERA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ERA_ECOLI octanol swissprot:ERA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ERA_ECOLI pepcoil swissprot:ERA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ERA_ECOLI pepdigest swissprot:ERA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ERA_ECOLI pepinfo swissprot:ERA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ERA_ECOLI pepnet swissprot:ERA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ERA_ECOLI pepstats swissprot:ERA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ERA_ECOLI pepwheel swissprot:ERA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ERA_ECOLI pepwindow swissprot:ERA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ERA_ECOLI sigcleave swissprot:ERA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ERA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262321 8 # CDD cd00207 fer2 # COFACTOR XDHC_ECOLI Name=[2Fe-2S] cluster; Xref=ChEBI CHEBI 49601; Evidence={ECO 0000250}; Note=Binds 2 [2Fe-2S] clusters. {ECO 0000250}; # EcoGene EG13051 xdhC # FUNCTION XDHC_ECOLI Iron-sulfur subunit of the xanthine dehydrogenase complex. # GO_function GO:0009055 electron carrier activity; IEA:InterPro. # GO_function GO:0016491 oxidoreductase activity; IEA:InterPro. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051537 2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0006166 purine ribonucleoside salvage; IEA:UniProtKB-KW. # GO_process GO:0009114 hypoxanthine catabolic process; IEA:UniProtKB-UniPathway. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.150.120 -; 1. # Gene3D 3.10.20.30 -; 1. # IntAct Q46801 4 # InterPro IPR001041 2Fe-2S_ferredoxin-type # InterPro IPR002888 2Fe-2S-bd # InterPro IPR012675 Beta-grasp_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Pathway ko00230 Purine metabolism # Organism XDHC_ECOLI Escherichia coli (strain K12) # PATHWAY Purine metabolism; hypoxanthine degradation; urate from hypoxanthine step 1/2. # PATRIC 32121146 VBIEscCol129921_2961 # PIR D65070 D65070 # PROSITE PS51085 2FE2S_FER_2 # Pfam PF00111 Fer2 # Pfam PF01799 Fer2_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName XDHC_ECOLI Xanthine dehydrogenase iron-sulfur-binding subunit # RefSeq NP_417344 NC_000913.3 # RefSeq WP_001016605 NZ_LN832404.1 # SIMILARITY Contains 1 2Fe-2S ferredoxin-type domain. {ECO:0000255|PROSITE-ProRule PRU00465}. # SUBUNIT Heterotrimer of XdhA, XdhB and XdhC. {ECO 0000305}. # SUPFAM SSF47741 SSF47741 # SUPFAM SSF54292 SSF54292 # UniPathway UPA00604 UER00661 # eggNOG COG2080 LUCA # eggNOG ENOG4108UTP Bacteria BLAST swissprot:XDHC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:XDHC_ECOLI BioCyc ECOL316407:JW2836-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2836-MONOMER BioCyc EcoCyc:G7487-MONOMER http://biocyc.org/getid?id=EcoCyc:G7487-MONOMER BioCyc MetaCyc:G7487-MONOMER http://biocyc.org/getid?id=MetaCyc:G7487-MONOMER COG COG2080 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2080 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.19.5332-5341.2000 http://dx.doi.org/10.1128/JB.182.19.5332-5341.2000 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 EchoBASE EB2863 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2863 EcoGene EG13051 http://www.ecogene.org/geneInfo.php?eg_id=EG13051 EnsemblBacteria AAC75906 http://www.ensemblgenomes.org/id/AAC75906 EnsemblBacteria AAC75906 http://www.ensemblgenomes.org/id/AAC75906 EnsemblBacteria BAE76934 http://www.ensemblgenomes.org/id/BAE76934 EnsemblBacteria BAE76934 http://www.ensemblgenomes.org/id/BAE76934 EnsemblBacteria BAE76934 http://www.ensemblgenomes.org/id/BAE76934 EnsemblBacteria b2868 http://www.ensemblgenomes.org/id/b2868 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051537 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051537 GO_process GO:0006166 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006166 GO_process GO:0009114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009114 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.150.120 http://www.cathdb.info/version/latest/superfamily/1.10.150.120 Gene3D 3.10.20.30 http://www.cathdb.info/version/latest/superfamily/3.10.20.30 GeneID 945148 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945148 HOGENOM HOG000166647 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000166647&db=HOGENOM6 InParanoid Q46801 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46801 IntAct Q46801 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46801* InterPro IPR001041 http://www.ebi.ac.uk/interpro/entry/IPR001041 InterPro IPR002888 http://www.ebi.ac.uk/interpro/entry/IPR002888 InterPro IPR012675 http://www.ebi.ac.uk/interpro/entry/IPR012675 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Gene ecj:JW2836 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2836 KEGG_Gene eco:b2868 http://www.genome.jp/dbget-bin/www_bget?eco:b2868 KEGG_Orthology KO:K13480 http://www.genome.jp/dbget-bin/www_bget?KO:K13480 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Reaction rn:R01768 http://www.genome.jp/dbget-bin/www_bget?rn:R01768 KEGG_Reaction rn:R02103 http://www.genome.jp/dbget-bin/www_bget?rn:R02103 OMA IQCEING http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IQCEING PROSITE PS51085 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51085 PSORT swissprot:XDHC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:XDHC_ECOLI PSORT-B swissprot:XDHC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:XDHC_ECOLI PSORT2 swissprot:XDHC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:XDHC_ECOLI Pfam PF00111 http://pfam.xfam.org/family/PF00111 Pfam PF01799 http://pfam.xfam.org/family/PF01799 Phobius swissprot:XDHC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:XDHC_ECOLI PhylomeDB Q46801 http://phylomedb.org/?seqid=Q46801 ProteinModelPortal Q46801 http://www.proteinmodelportal.org/query/uniprot/Q46801 PubMed 10986234 http://www.ncbi.nlm.nih.gov/pubmed/10986234 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417344 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417344 RefSeq WP_001016605 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001016605 SMR Q46801 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46801 STRING 511145.b2868 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2868&targetmode=cogs STRING COG2080 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2080&targetmode=cogs SUPFAM SSF47741 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47741 SUPFAM SSF54292 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54292 UniProtKB XDHC_ECOLI http://www.uniprot.org/uniprot/XDHC_ECOLI UniProtKB-AC Q46801 http://www.uniprot.org/uniprot/Q46801 charge swissprot:XDHC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:XDHC_ECOLI eggNOG COG2080 http://eggnogapi.embl.de/nog_data/html/tree/COG2080 eggNOG ENOG4108UTP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UTP epestfind swissprot:XDHC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:XDHC_ECOLI garnier swissprot:XDHC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:XDHC_ECOLI helixturnhelix swissprot:XDHC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:XDHC_ECOLI hmoment swissprot:XDHC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:XDHC_ECOLI iep swissprot:XDHC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:XDHC_ECOLI inforesidue swissprot:XDHC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:XDHC_ECOLI octanol swissprot:XDHC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:XDHC_ECOLI pepcoil swissprot:XDHC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:XDHC_ECOLI pepdigest swissprot:XDHC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:XDHC_ECOLI pepinfo swissprot:XDHC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:XDHC_ECOLI pepnet swissprot:XDHC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:XDHC_ECOLI pepstats swissprot:XDHC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:XDHC_ECOLI pepwheel swissprot:XDHC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:XDHC_ECOLI pepwindow swissprot:XDHC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:XDHC_ECOLI sigcleave swissprot:XDHC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:XDHC_ECOLI ## Database ID URL or Descriptions # EcoGene EG14477 ymiB # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # Organism YMIB_ECOLI Escherichia coli (strain K12) # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YMIB_ECOLI Putative protein YmiB # RefSeq WP_000221855 NZ_LN832404.1 # RefSeq YP_002791239 NC_000913.3 # SUBCELLULAR LOCATION YMIB_ECOLI Membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. BLAST swissprot:YMIB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YMIB_ECOLI DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14477 http://www.ecogene.org/geneInfo.php?eg_id=EG14477 EnsemblBacteria ACO59991 http://www.ensemblgenomes.org/id/ACO59991 EnsemblBacteria ACO59991 http://www.ensemblgenomes.org/id/ACO59991 EnsemblBacteria b4672 http://www.ensemblgenomes.org/id/b4672 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GeneID 7751616 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7751616 KEGG_Gene eco:b4672 http://www.genome.jp/dbget-bin/www_bget?eco:b4672 PSORT swissprot:YMIB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YMIB_ECOLI PSORT-B swissprot:YMIB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YMIB_ECOLI PSORT2 swissprot:YMIB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YMIB_ECOLI Phobius swissprot:YMIB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YMIB_ECOLI ProteinModelPortal C1P5Z9 http://www.proteinmodelportal.org/query/uniprot/C1P5Z9 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000221855 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000221855 RefSeq YP_002791239 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_002791239 STRING 511145.b4672 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4672&targetmode=cogs UniProtKB YMIB_ECOLI http://www.uniprot.org/uniprot/YMIB_ECOLI UniProtKB-AC C1P5Z9 http://www.uniprot.org/uniprot/C1P5Z9 charge swissprot:YMIB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YMIB_ECOLI epestfind swissprot:YMIB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YMIB_ECOLI garnier swissprot:YMIB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YMIB_ECOLI helixturnhelix swissprot:YMIB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YMIB_ECOLI hmoment swissprot:YMIB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YMIB_ECOLI iep swissprot:YMIB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YMIB_ECOLI inforesidue swissprot:YMIB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YMIB_ECOLI octanol swissprot:YMIB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YMIB_ECOLI pepcoil swissprot:YMIB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YMIB_ECOLI pepdigest swissprot:YMIB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YMIB_ECOLI pepinfo swissprot:YMIB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YMIB_ECOLI pepnet swissprot:YMIB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YMIB_ECOLI pepstats swissprot:YMIB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YMIB_ECOLI pepwheel swissprot:YMIB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YMIB_ECOLI pepwindow swissprot:YMIB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YMIB_ECOLI sigcleave swissprot:YMIB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YMIB_ECOLI ## Database ID URL or Descriptions # BioGrid 4262134 14 # EcoGene EG14082 yfaT # Gene3D 3.90.1720.10 -; 1. # InterPro IPR000064 NLP_P60_dom # InterPro IPR009558 DUF1175 # Organism YFAT_ECOLI Escherichia coli (strain K12) # PATRIC 32119817 VBIEscCol129921_2318 # Pfam PF06672 DUF1175 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFAT_ECOLI Uncharacterized protein YfaT # RefSeq NP_416732 NC_000913.3 # RefSeq WP_001295211 NZ_LN832404.1 # SIMILARITY To P.aeruginosa PA4490 and T.maritima TM0986. {ECO 0000305}. # eggNOG COG3234 LUCA # eggNOG ENOG4108QJJ Bacteria BLAST swissprot:YFAT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFAT_ECOLI BioCyc ECOL316407:JW2223-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2223-MONOMER BioCyc EcoCyc:G7156-MONOMER http://biocyc.org/getid?id=EcoCyc:G7156-MONOMER COG COG3234 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3234 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3835 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3835 EcoGene EG14082 http://www.ecogene.org/geneInfo.php?eg_id=EG14082 EnsemblBacteria AAC75289 http://www.ensemblgenomes.org/id/AAC75289 EnsemblBacteria AAC75289 http://www.ensemblgenomes.org/id/AAC75289 EnsemblBacteria BAE76671 http://www.ensemblgenomes.org/id/BAE76671 EnsemblBacteria BAE76671 http://www.ensemblgenomes.org/id/BAE76671 EnsemblBacteria BAE76671 http://www.ensemblgenomes.org/id/BAE76671 EnsemblBacteria b2229 http://www.ensemblgenomes.org/id/b2229 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.90.1720.10 http://www.cathdb.info/version/latest/superfamily/3.90.1720.10 GeneID 946622 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946622 HOGENOM HOG000122356 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122356&db=HOGENOM6 InParanoid P76466 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76466 InterPro IPR000064 http://www.ebi.ac.uk/interpro/entry/IPR000064 InterPro IPR009558 http://www.ebi.ac.uk/interpro/entry/IPR009558 KEGG_Gene ecj:JW2223 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2223 KEGG_Gene eco:b2229 http://www.genome.jp/dbget-bin/www_bget?eco:b2229 KEGG_Orthology KO:K09934 http://www.genome.jp/dbget-bin/www_bget?KO:K09934 OMA THRDCAG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=THRDCAG PSORT swissprot:YFAT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFAT_ECOLI PSORT-B swissprot:YFAT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFAT_ECOLI PSORT2 swissprot:YFAT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFAT_ECOLI Pfam PF06672 http://pfam.xfam.org/family/PF06672 Phobius swissprot:YFAT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFAT_ECOLI PhylomeDB P76466 http://phylomedb.org/?seqid=P76466 ProteinModelPortal P76466 http://www.proteinmodelportal.org/query/uniprot/P76466 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416732 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416732 RefSeq WP_001295211 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295211 STRING 511145.b2229 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2229&targetmode=cogs STRING COG3234 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3234&targetmode=cogs UniProtKB YFAT_ECOLI http://www.uniprot.org/uniprot/YFAT_ECOLI UniProtKB-AC P76466 http://www.uniprot.org/uniprot/P76466 charge swissprot:YFAT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFAT_ECOLI eggNOG COG3234 http://eggnogapi.embl.de/nog_data/html/tree/COG3234 eggNOG ENOG4108QJJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108QJJ epestfind swissprot:YFAT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFAT_ECOLI garnier swissprot:YFAT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFAT_ECOLI helixturnhelix swissprot:YFAT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFAT_ECOLI hmoment swissprot:YFAT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFAT_ECOLI iep swissprot:YFAT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFAT_ECOLI inforesidue swissprot:YFAT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFAT_ECOLI octanol swissprot:YFAT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFAT_ECOLI pepcoil swissprot:YFAT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFAT_ECOLI pepdigest swissprot:YFAT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFAT_ECOLI pepinfo swissprot:YFAT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFAT_ECOLI pepnet swissprot:YFAT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFAT_ECOLI pepstats swissprot:YFAT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFAT_ECOLI pepwheel swissprot:YFAT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFAT_ECOLI pepwindow swissprot:YFAT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFAT_ECOLI sigcleave swissprot:YFAT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFAT_ECOLI ## Database ID URL or Descriptions # BioGrid 4260449 6 # CAUTION YEHY_ECOLI Was originally thought to be part of an osmoprotectant uptake system (PubMed 15251200). However, it was shown later that the complex does not mediate osmotic stress protection (PubMed 26325238). {ECO 0000305|PubMed 15251200, ECO 0000305|PubMed 26325238}. # CDD cd06261 TM_PBP2 # EcoGene EG12011 yehY # FUNCTION YEHY_ECOLI Part of an ABC transporter complex involved in low- affinity glycine betaine uptake. Probably responsible for the translocation of the substrate across the membrane. {ECO 0000269|PubMed 26325238}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005215 transporter activity; IBA:GO_Central. # GO_process GO:0006865 amino acid transport; IEA:UniProtKB-KW. # GO_process GO:0031460 glycine betaine transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006810 transport # Gene3D 1.10.3720.10 -; 1. # INDUCTION Expression is sigma S-dependent. Induced by both osmotic shock and entry into stationary phase. {ECO:0000269|PubMed 15251200}. # IntAct P33361 2 # InterPro IPR000515 MetI-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00209 Osmoprotectant transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism YEHY_ECOLI Escherichia coli (strain K12) # PATRIC 32119599 VBIEscCol129921_2210 # PIR A64981 A64981 # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Glycine betaine uptake system permease protein YehY {ECO 0000305} # RefSeq NP_416634 NC_000913.3 # RefSeq WP_000220837 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA60493.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION YEHY_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255}. # SUBUNIT The complex is composed of two ATP-binding proteins (YehX), two transmembrane proteins (YehW and YehY) and a solute- binding protein (YehZ). {ECO 0000305}. # SUPFAM SSF161098 SSF161098 # TCDB 3.A.1.12.15 the atp-binding cassette (abc) superfamily # eggNOG COG1174 LUCA # eggNOG ENOG4107T5X Bacteria BLAST swissprot:YEHY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEHY_ECOLI BioCyc ECOL316407:JW2118-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2118-MONOMER BioCyc EcoCyc:YEHY-MONOMER http://biocyc.org/getid?id=EcoCyc:YEHY-MONOMER BioCyc MetaCyc:YEHY-MONOMER http://biocyc.org/getid?id=MetaCyc:YEHY-MONOMER COG COG1174 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1174 DIP DIP-11913N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11913N DOI 10.1016/j.femsle.2004.05.046 http://dx.doi.org/10.1016/j.femsle.2004.05.046 DOI 10.1021/acs.biochem.5b00274 http://dx.doi.org/10.1021/acs.biochem.5b00274 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1949 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1949 EcoGene EG12011 http://www.ecogene.org/geneInfo.php?eg_id=EG12011 EnsemblBacteria AAC75191 http://www.ensemblgenomes.org/id/AAC75191 EnsemblBacteria AAC75191 http://www.ensemblgenomes.org/id/AAC75191 EnsemblBacteria BAE76607 http://www.ensemblgenomes.org/id/BAE76607 EnsemblBacteria BAE76607 http://www.ensemblgenomes.org/id/BAE76607 EnsemblBacteria BAE76607 http://www.ensemblgenomes.org/id/BAE76607 EnsemblBacteria b2130 http://www.ensemblgenomes.org/id/b2130 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_process GO:0006865 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865 GO_process GO:0031460 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031460 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 946660 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946660 HOGENOM HOG000218077 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218077&db=HOGENOM6 InParanoid P33361 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33361 IntAct P33361 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33361* InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2118 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2118 KEGG_Gene eco:b2130 http://www.genome.jp/dbget-bin/www_bget?eco:b2130 KEGG_Orthology KO:K05846 http://www.genome.jp/dbget-bin/www_bget?KO:K05846 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 MINT MINT-1271646 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1271646 OMA SPGSGLW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SPGSGLW PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:YEHY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEHY_ECOLI PSORT-B swissprot:YEHY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEHY_ECOLI PSORT2 swissprot:YEHY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEHY_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Phobius swissprot:YEHY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEHY_ECOLI ProteinModelPortal P33361 http://www.proteinmodelportal.org/query/uniprot/P33361 PubMed 15251200 http://www.ncbi.nlm.nih.gov/pubmed/15251200 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 26325238 http://www.ncbi.nlm.nih.gov/pubmed/26325238 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416634 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416634 RefSeq WP_000220837 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000220837 STRING 511145.b2130 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2130&targetmode=cogs STRING COG1174 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1174&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.12.15 http://www.tcdb.org/search/result.php?tc=3.A.1.12.15 UniProtKB YEHY_ECOLI http://www.uniprot.org/uniprot/YEHY_ECOLI UniProtKB-AC P33361 http://www.uniprot.org/uniprot/P33361 charge swissprot:YEHY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEHY_ECOLI eggNOG COG1174 http://eggnogapi.embl.de/nog_data/html/tree/COG1174 eggNOG ENOG4107T5X http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107T5X epestfind swissprot:YEHY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEHY_ECOLI garnier swissprot:YEHY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEHY_ECOLI helixturnhelix swissprot:YEHY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEHY_ECOLI hmoment swissprot:YEHY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEHY_ECOLI iep swissprot:YEHY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEHY_ECOLI inforesidue swissprot:YEHY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEHY_ECOLI octanol swissprot:YEHY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEHY_ECOLI pepcoil swissprot:YEHY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEHY_ECOLI pepdigest swissprot:YEHY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEHY_ECOLI pepinfo swissprot:YEHY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEHY_ECOLI pepnet swissprot:YEHY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEHY_ECOLI pepstats swissprot:YEHY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEHY_ECOLI pepwheel swissprot:YEHY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEHY_ECOLI pepwindow swissprot:YEHY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEHY_ECOLI sigcleave swissprot:YEHY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEHY_ECOLI ## Database ID URL or Descriptions # BioGrid 4262250 11 # EcoGene EG13210 yfjX # IntAct P52139 3 # InterPro IPR004914 Antirestrict # Organism YFJX_ECOLI Escherichia coli (strain K12) # PATRIC 32120679 VBIEscCol129921_2738 # PIR E65043 E65043 # Pfam PF03230 Antirestrict # ProDom PD012854 Antirestrict # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFJX_ECOLI Uncharacterized protein YfjX # RefSeq NP_417130 NC_000913.3 # RefSeq WP_000211841 NZ_LN832404.1 # SIMILARITY Belongs to the antirestriction protein family. {ECO 0000305}. # eggNOG ENOG4105MFG Bacteria # eggNOG ENOG4111V8R LUCA BLAST swissprot:YFJX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFJX_ECOLI BioCyc ECOL316407:JW2624-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2624-MONOMER BioCyc EcoCyc:G7378-MONOMER http://biocyc.org/getid?id=EcoCyc:G7378-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36840 http://www.ebi.ac.uk/ena/data/view/U36840 EchoBASE EB3002 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3002 EcoGene EG13210 http://www.ecogene.org/geneInfo.php?eg_id=EG13210 EnsemblBacteria AAC75691 http://www.ensemblgenomes.org/id/AAC75691 EnsemblBacteria AAC75691 http://www.ensemblgenomes.org/id/AAC75691 EnsemblBacteria BAA16511 http://www.ensemblgenomes.org/id/BAA16511 EnsemblBacteria BAA16511 http://www.ensemblgenomes.org/id/BAA16511 EnsemblBacteria BAA16511 http://www.ensemblgenomes.org/id/BAA16511 EnsemblBacteria b2643 http://www.ensemblgenomes.org/id/b2643 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947126 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947126 HOGENOM HOG000124758 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000124758&db=HOGENOM6 IntAct P52139 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P52139* InterPro IPR004914 http://www.ebi.ac.uk/interpro/entry/IPR004914 KEGG_Gene ecj:JW2624 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2624 KEGG_Gene eco:b2643 http://www.genome.jp/dbget-bin/www_bget?eco:b2643 OMA ELRIGFW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ELRIGFW PSORT swissprot:YFJX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFJX_ECOLI PSORT-B swissprot:YFJX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFJX_ECOLI PSORT2 swissprot:YFJX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFJX_ECOLI Pfam PF03230 http://pfam.xfam.org/family/PF03230 Phobius swissprot:YFJX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFJX_ECOLI PhylomeDB P52139 http://phylomedb.org/?seqid=P52139 ProteinModelPortal P52139 http://www.proteinmodelportal.org/query/uniprot/P52139 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417130 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417130 RefSeq WP_000211841 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000211841 SMR P52139 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P52139 STRING 511145.b2643 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2643&targetmode=cogs UniProtKB YFJX_ECOLI http://www.uniprot.org/uniprot/YFJX_ECOLI UniProtKB-AC P52139 http://www.uniprot.org/uniprot/P52139 charge swissprot:YFJX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFJX_ECOLI eggNOG ENOG4105MFG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105MFG eggNOG ENOG4111V8R http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111V8R epestfind swissprot:YFJX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFJX_ECOLI garnier swissprot:YFJX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFJX_ECOLI helixturnhelix swissprot:YFJX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFJX_ECOLI hmoment swissprot:YFJX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFJX_ECOLI iep swissprot:YFJX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFJX_ECOLI inforesidue swissprot:YFJX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFJX_ECOLI octanol swissprot:YFJX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFJX_ECOLI pepcoil swissprot:YFJX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFJX_ECOLI pepdigest swissprot:YFJX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFJX_ECOLI pepinfo swissprot:YFJX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFJX_ECOLI pepnet swissprot:YFJX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFJX_ECOLI pepstats swissprot:YFJX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFJX_ECOLI pepwheel swissprot:YFJX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFJX_ECOLI pepwindow swissprot:YFJX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFJX_ECOLI sigcleave swissprot:YFJX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFJX_ECOLI ## Database ID URL or Descriptions # AltName PTPB1_ECOLI EIIB-Aga # AltName PTPB1_ECOLI PTS system N-acetylgalactosamine-specific EIIB component 1 # BioGrid 4259399 11 # CATALYTIC ACTIVITY Protein EIIB N(pi)-phospho-L- histidine/cysteine + sugar = protein EIIB + sugar phosphate. {ECO:0000255|PROSITE-ProRule PRU00424}. # CDD cd00001 PTS_IIB_man # DOMAIN PTPB1_ECOLI The EIIB domain is phosphorylated by phospho-EIIA on a cysteinyl or histidyl residue, depending on the transported sugar. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the EIIC domain. # EcoGene EG12769 agaB # FUNCTION PTPB1_ECOLI The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylgalactosamine transport. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0008982 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:InterPro. # GO_function GO:0016301 kinase activity; IEA:UniProtKB-KW. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # Gene3D 3.40.35.10 -; 1. # IntAct P42909 5 # InterPro IPR004720 PTS_IIB_sorbose-sp # InterPro IPR018455 PTS_IIB_sorbose-sp_subgr # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00287 PTS system, galactosamine-specific II component # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko00052 Galactose metabolism # KEGG_Pathway ko02060 Phosphotransferase system (PTS) # Organism PTPB1_ECOLI Escherichia coli (strain K12) # PATRIC 32121694 VBIEscCol129921_3233 # PIR F65103 F65103 # PROSITE PS51101 PTS_EIIB_TYPE_4 # Pfam PF03830 PTSIIB_sorb # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PTPB1_ECOLI N-acetylgalactosamine-specific phosphotransferase enzyme IIB component 1 # RefSeq NP_417607 NC_000913.3 # RefSeq WP_000203711 NZ_LN832404.1 # SIMILARITY Contains 1 PTS EIIB type-4 domain. {ECO:0000255|PROSITE-ProRule PRU00424}. # SUBCELLULAR LOCATION PTPB1_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF52728 SSF52728 # TCDB 4.A.6.1 the pts mannose-fructose-sorbose (man) family # TIGRFAMs TIGR00854 pts-sorbose # eggNOG COG3444 LUCA # eggNOG ENOG4108UZY Bacteria BLAST swissprot:PTPB1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTPB1_ECOLI BioCyc ECOL316407:JW3107-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3107-MONOMER BioCyc EcoCyc:AGAB-MONOMER http://biocyc.org/getid?id=EcoCyc:AGAB-MONOMER COG COG3444 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3444 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2000.01969.x http://dx.doi.org/10.1046/j.1365-2958.2000.01969.x DOI 10.1099/13500872-142-2-231 http://dx.doi.org/10.1099/13500872-142-2-231 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.- EMBL AF228498 http://www.ebi.ac.uk/ena/data/view/AF228498 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 2.7.1.- http://enzyme.expasy.org/EC/2.7.1.- EchoBASE EB2622 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2622 EcoGene EG12769 http://www.ecogene.org/geneInfo.php?eg_id=EG12769 EnsemblBacteria AAC76172 http://www.ensemblgenomes.org/id/AAC76172 EnsemblBacteria AAC76172 http://www.ensemblgenomes.org/id/AAC76172 EnsemblBacteria BAE77184 http://www.ensemblgenomes.org/id/BAE77184 EnsemblBacteria BAE77184 http://www.ensemblgenomes.org/id/BAE77184 EnsemblBacteria BAE77184 http://www.ensemblgenomes.org/id/BAE77184 EnsemblBacteria b3138 http://www.ensemblgenomes.org/id/b3138 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0008982 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008982 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.40.35.10 http://www.cathdb.info/version/latest/superfamily/3.40.35.10 GeneID 947653 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947653 HOGENOM HOG000096437 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000096437&db=HOGENOM6 InParanoid P42909 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P42909 IntAct P42909 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P42909* IntEnz 2.7.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1 InterPro IPR004720 http://www.ebi.ac.uk/interpro/entry/IPR004720 InterPro IPR018455 http://www.ebi.ac.uk/interpro/entry/IPR018455 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3107 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3107 KEGG_Gene eco:b3138 http://www.genome.jp/dbget-bin/www_bget?eco:b3138 KEGG_Orthology KO:K10984 http://www.genome.jp/dbget-bin/www_bget?KO:K10984 KEGG_Pathway ko00052 http://www.genome.jp/kegg-bin/show_pathway?ko00052 KEGG_Pathway ko02060 http://www.genome.jp/kegg-bin/show_pathway?ko02060 KEGG_Reaction rn:R08367 http://www.genome.jp/dbget-bin/www_bget?rn:R08367 OMA HKASERQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HKASERQ PROSITE PS51101 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51101 PSORT swissprot:PTPB1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTPB1_ECOLI PSORT-B swissprot:PTPB1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTPB1_ECOLI PSORT2 swissprot:PTPB1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTPB1_ECOLI Pfam PF03830 http://pfam.xfam.org/family/PF03830 Phobius swissprot:PTPB1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTPB1_ECOLI PhylomeDB P42909 http://phylomedb.org/?seqid=P42909 ProteinModelPortal P42909 http://www.proteinmodelportal.org/query/uniprot/P42909 PubMed 10931310 http://www.ncbi.nlm.nih.gov/pubmed/10931310 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8932697 http://www.ncbi.nlm.nih.gov/pubmed/8932697 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417607 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417607 RefSeq WP_000203711 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000203711 SMR P42909 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P42909 STRING 511145.b3138 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3138&targetmode=cogs STRING COG3444 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3444&targetmode=cogs SUPFAM SSF52728 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52728 TCDB 4.A.6.1 http://www.tcdb.org/search/result.php?tc=4.A.6.1 TIGRFAMs TIGR00854 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00854 UniProtKB PTPB1_ECOLI http://www.uniprot.org/uniprot/PTPB1_ECOLI UniProtKB-AC P42909 http://www.uniprot.org/uniprot/P42909 charge swissprot:PTPB1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTPB1_ECOLI eggNOG COG3444 http://eggnogapi.embl.de/nog_data/html/tree/COG3444 eggNOG ENOG4108UZY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UZY epestfind swissprot:PTPB1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTPB1_ECOLI garnier swissprot:PTPB1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTPB1_ECOLI helixturnhelix swissprot:PTPB1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTPB1_ECOLI hmoment swissprot:PTPB1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTPB1_ECOLI iep swissprot:PTPB1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTPB1_ECOLI inforesidue swissprot:PTPB1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTPB1_ECOLI octanol swissprot:PTPB1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTPB1_ECOLI pepcoil swissprot:PTPB1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTPB1_ECOLI pepdigest swissprot:PTPB1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTPB1_ECOLI pepinfo swissprot:PTPB1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTPB1_ECOLI pepnet swissprot:PTPB1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTPB1_ECOLI pepstats swissprot:PTPB1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTPB1_ECOLI pepwheel swissprot:PTPB1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTPB1_ECOLI pepwindow swissprot:PTPB1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTPB1_ECOLI sigcleave swissprot:PTPB1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTPB1_ECOLI ## Database ID URL or Descriptions # EcoGene EG40014 insN # FUNCTION INSN2_ECOLI Involved in the transposition of the insertion sequence IS911. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 1.10.10.60 -; 1. # InterPro IPR002514 Transposase_8 # InterPro IPR009057 Homeodomain-like # Organism INSN2_ECOLI Escherichia coli (strain K12) # PATRIC 48668134 VBIEscCol107702_4318 # PIR S56508 S56508 # Pfam PF01527 HTH_Tnp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSN2_ECOLI Transposase InsN for insertion sequence element IS911B # RefSeq WP_032244723 NZ_CP010445.1 # SEQUENCE CAUTION Sequence=BAE78275.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the transposase 8 family. {ECO 0000305}. # SUPFAM SSF46689 SSF46689 BLAST swissprot:INSN2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSN2_ECOLI BioCyc ECOL316407:JW5771-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5771-MONOMER BioCyc EcoCyc:G7904-MONOMER http://biocyc.org/getid?id=EcoCyc:G7904-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB4745 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4745 EcoGene EG40014 http://www.ecogene.org/geneInfo.php?eg_id=EG40014 EnsemblBacteria BAE78275 http://www.ensemblgenomes.org/id/BAE78275 EnsemblBacteria BAE78275 http://www.ensemblgenomes.org/id/BAE78275 EnsemblBacteria BAE78275 http://www.ensemblgenomes.org/id/BAE78275 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 InParanoid P39212 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39212 IntAct P39212 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39212* InterPro IPR002514 http://www.ebi.ac.uk/interpro/entry/IPR002514 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 KEGG_Gene ecj:JW5771 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5771 OMA SITQACK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SITQACK PSORT swissprot:INSN2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSN2_ECOLI PSORT-B swissprot:INSN2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSN2_ECOLI PSORT2 swissprot:INSN2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSN2_ECOLI Pfam PF01527 http://pfam.xfam.org/family/PF01527 Phobius swissprot:INSN2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSN2_ECOLI PhylomeDB P39212 http://phylomedb.org/?seqid=P39212 ProteinModelPortal P39212 http://www.proteinmodelportal.org/query/uniprot/P39212 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_032244723 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_032244723 STRING 316407.85677025 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85677025&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 UniProtKB INSN2_ECOLI http://www.uniprot.org/uniprot/INSN2_ECOLI UniProtKB-AC P39212 http://www.uniprot.org/uniprot/P39212 charge swissprot:INSN2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSN2_ECOLI epestfind swissprot:INSN2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSN2_ECOLI garnier swissprot:INSN2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSN2_ECOLI helixturnhelix swissprot:INSN2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSN2_ECOLI hmoment swissprot:INSN2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSN2_ECOLI iep swissprot:INSN2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSN2_ECOLI inforesidue swissprot:INSN2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSN2_ECOLI octanol swissprot:INSN2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSN2_ECOLI pepcoil swissprot:INSN2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSN2_ECOLI pepdigest swissprot:INSN2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSN2_ECOLI pepinfo swissprot:INSN2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSN2_ECOLI pepnet swissprot:INSN2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSN2_ECOLI pepstats swissprot:INSN2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSN2_ECOLI pepwheel swissprot:INSN2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSN2_ECOLI pepwindow swissprot:INSN2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSN2_ECOLI sigcleave swissprot:INSN2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSN2_ECOLI ## Database ID URL or Descriptions # EcoGene EG14396 ypfM # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GOslim_component GO:0005737 cytoplasm # INDUCTION YPFM_ECOLI Constitutively expressed (PubMed 19121005), increases in stationary phase and at 45 degrees Celsius (PubMed 19121005) (at protein level). {ECO 0000269|PubMed 19121005, ECO 0000269|PubMed 19734316}. # Organism YPFM_ECOLI Escherichia coli (strain K12) # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YPFM_ECOLI Uncharacterized protein YpfM # RefSeq YP_001165325 NC_000913.3 # SUBCELLULAR LOCATION YPFM_ECOLI Cytoplasm {ECO 0000269|PubMed 19121005}. BLAST swissprot:YPFM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YPFM_ECOLI BioCyc EcoCyc:MONOMER0-762 http://biocyc.org/getid?id=EcoCyc:MONOMER0-762 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2008.06495.x http://dx.doi.org/10.1111/j.1365-2958.2008.06495.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00872-09 http://dx.doi.org/10.1128/JB.00872-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14396 http://www.ecogene.org/geneInfo.php?eg_id=EG14396 EnsemblBacteria ABP93450 http://www.ensemblgenomes.org/id/ABP93450 EnsemblBacteria ABP93450 http://www.ensemblgenomes.org/id/ABP93450 EnsemblBacteria b4606 http://www.ensemblgenomes.org/id/b4606 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GeneID 5061513 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5061513 KEGG_Gene eco:b4606 http://www.genome.jp/dbget-bin/www_bget?eco:b4606 PSORT swissprot:YPFM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YPFM_ECOLI PSORT-B swissprot:YPFM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YPFM_ECOLI PSORT2 swissprot:YPFM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YPFM_ECOLI Phobius swissprot:YPFM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YPFM_ECOLI PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19121005 http://www.ncbi.nlm.nih.gov/pubmed/19121005 PubMed 19734316 http://www.ncbi.nlm.nih.gov/pubmed/19734316 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq YP_001165325 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001165325 STRING 511145.b4606 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4606&targetmode=cogs UniProtKB YPFM_ECOLI http://www.uniprot.org/uniprot/YPFM_ECOLI UniProtKB-AC A5A621 http://www.uniprot.org/uniprot/A5A621 charge swissprot:YPFM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YPFM_ECOLI epestfind swissprot:YPFM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YPFM_ECOLI garnier swissprot:YPFM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YPFM_ECOLI helixturnhelix swissprot:YPFM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YPFM_ECOLI hmoment swissprot:YPFM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YPFM_ECOLI iep swissprot:YPFM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YPFM_ECOLI inforesidue swissprot:YPFM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YPFM_ECOLI octanol swissprot:YPFM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YPFM_ECOLI pepcoil swissprot:YPFM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YPFM_ECOLI pepdigest swissprot:YPFM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YPFM_ECOLI pepinfo swissprot:YPFM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YPFM_ECOLI pepnet swissprot:YPFM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YPFM_ECOLI pepstats swissprot:YPFM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YPFM_ECOLI pepwheel swissprot:YPFM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YPFM_ECOLI pepwindow swissprot:YPFM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YPFM_ECOLI sigcleave swissprot:YPFM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YPFM_ECOLI ## Database ID URL or Descriptions # CDD cd07026 Ribosomal_L20 # EcoGene EG10881 rplT # FUNCTION RL20_ECOLI One of the primary rRNA binding proteins, it binds close to the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. {ECO 0000269|PubMed 3298242}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0022625 cytosolic large ribosomal subunit; IDA:EcoCyc. # GO_function GO:0000900 translation repressor activity, nucleic acid binding; IDA:EcoCyc. # GO_function GO:0003735 structural constituent of ribosome; IDA:EcoCyc. # GO_function GO:0019843 rRNA binding; IEA:UniProtKB-HAMAP. # GO_process GO:0000027 ribosomal large subunit assembly; IDA:EcoCyc. # GO_process GO:0006412 translation; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_function GO:0019843 rRNA binding # GOslim_process GO:0006412 translation # GOslim_process GO:0022618 ribonucleoprotein complex assembly # HAMAP MF_00382 Ribosomal_L20 # IntAct P0A7L3 35 # InterPro IPR005813 Ribosomal_L20 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=13366.9; Method=MALDI; Range=2-118; Evidence={ECO:0000269|PubMed 10094780}; # Organism RL20_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10986 PTHR10986 # PATRIC 32118736 VBIEscCol129921_1786 # PDB 2J28 EM; 8.00 A; Q=2-118 # PDB 2RDO EM; 9.10 A; Q=2-118 # PDB 3BBX EM; 10.00 A; Q=2-118 # PDB 3J5L EM; 6.60 A; Q=2-118 # PDB 3J7Z EM; 3.90 A; Q=1-118 # PDB 3J8G EM; 5.00 A; Q=1-118 # PDB 3J9Y EM; 3.90 A; Q=1-118 # PDB 3J9Z EM; 3.60 A; LO=2-118 # PDB 3JA1 EM; 3.60 A; LS=2-118 # PDB 3JBU EM; 3.64 A; q=1-118 # PDB 3JBV EM; 3.32 A; q=1-118 # PDB 3JCD EM; 3.70 A; Q=1-118 # PDB 3JCE EM; 3.20 A; Q=1-118 # PDB 3JCJ EM; 3.70 A; P=1-118 # PDB 3JCN EM; 4.60 A; Q=1-118 # PDB 4CSU EM; 5.50 A; Q=2-118 # PDB 4U1U X-ray; 2.95 A; BQ/DQ=2-118 # PDB 4U1V X-ray; 3.00 A; BQ/DQ=2-118 # PDB 4U20 X-ray; 2.90 A; BQ/DQ=2-118 # PDB 4U24 X-ray; 2.90 A; BQ/DQ=2-118 # PDB 4U25 X-ray; 2.90 A; BQ/DQ=2-118 # PDB 4U26 X-ray; 2.80 A; BQ/DQ=2-118 # PDB 4U27 X-ray; 2.80 A; BQ/DQ=2-118 # PDB 4UY8 EM; 3.80 A; Q=2-118 # PDB 4V47 EM; 12.30 A; AO=2-118 # PDB 4V48 EM; 11.50 A; AO=2-118 # PDB 4V4H X-ray; 3.46 A; BQ/DQ=1-118 # PDB 4V4Q X-ray; 3.46 A; BQ/DQ=2-118 # PDB 4V4V EM; 15.00 A; BO=3-117 # PDB 4V4W EM; 15.00 A; BO=3-117 # PDB 4V50 X-ray; 3.22 A; BQ/DQ=2-118 # PDB 4V52 X-ray; 3.21 A; BQ/DQ=2-118 # PDB 4V53 X-ray; 3.54 A; BQ/DQ=2-118 # PDB 4V54 X-ray; 3.30 A; BQ/DQ=2-118 # PDB 4V55 X-ray; 4.00 A; BQ/DQ=2-118 # PDB 4V56 X-ray; 3.93 A; BQ/DQ=2-118 # PDB 4V57 X-ray; 3.50 A; BQ/DQ=2-118 # PDB 4V5B X-ray; 3.74 A; AQ/CQ=2-118 # PDB 4V5H EM; 5.80 A; BQ=2-118 # PDB 4V5Y X-ray; 4.45 A; BQ/DQ=2-118 # PDB 4V64 X-ray; 3.50 A; BQ/DQ=2-118 # PDB 4V65 EM; 9.00 A; BJ=1-118 # PDB 4V66 EM; 9.00 A; BJ=1-118 # PDB 4V69 EM; 6.70 A; BQ=2-118 # PDB 4V6C X-ray; 3.19 A; BQ/DQ=1-118 # PDB 4V6D X-ray; 3.81 A; BQ/DQ=1-118 # PDB 4V6E X-ray; 3.71 A; BQ/DQ=1-118 # PDB 4V6K EM; 8.25 A; AR=1-118 # PDB 4V6L EM; 13.20 A; BR=1-118 # PDB 4V6M EM; 7.10 A; BQ=2-118 # PDB 4V6N EM; 12.10 A; AS=2-118 # PDB 4V6O EM; 14.70 A; BS=2-118 # PDB 4V6P EM; 13.50 A; BS=2-118 # PDB 4V6Q EM; 11.50 A; BS=2-118 # PDB 4V6R EM; 11.50 A; BS=2-118 # PDB 4V6S EM; 13.10 A; AS=2-118 # PDB 4V6T EM; 8.30 A; BQ=2-118 # PDB 4V6V EM; 9.80 A; BU=2-118 # PDB 4V6Y EM; 12.00 A; BQ=1-118 # PDB 4V6Z EM; 12.00 A; BQ=1-118 # PDB 4V70 EM; 17.00 A; BQ=1-118 # PDB 4V71 EM; 20.00 A; BQ=1-118 # PDB 4V72 EM; 13.00 A; BQ=1-118 # PDB 4V73 EM; 15.00 A; BQ=1-118 # PDB 4V74 EM; 17.00 A; BQ=1-118 # PDB 4V75 EM; 12.00 A; BQ=1-118 # PDB 4V76 EM; 17.00 A; BQ=1-118 # PDB 4V77 EM; 17.00 A; BQ=1-118 # PDB 4V78 EM; 20.00 A; BQ=1-118 # PDB 4V79 EM; 15.00 A; BQ=1-118 # PDB 4V7A EM; 9.00 A; BQ=1-118 # PDB 4V7B EM; 6.80 A; BQ=1-118 # PDB 4V7C EM; 7.60 A; BS=2-118 # PDB 4V7D EM; 7.60 A; AT=2-118 # PDB 4V7I EM; 9.60 A; AQ=1-118 # PDB 4V7S X-ray; 3.25 A; BQ/DQ=2-118 # PDB 4V7T X-ray; 3.19 A; BQ/DQ=2-118 # PDB 4V7U X-ray; 3.10 A; BQ/DQ=2-118 # PDB 4V7V X-ray; 3.29 A; BQ/DQ=2-118 # PDB 4V85 X-ray; 3.20 A; U=1-118 # PDB 4V89 X-ray; 3.70 A; BU=1-118 # PDB 4V9C X-ray; 3.30 A; BQ/DQ=1-118 # PDB 4V9D X-ray; 3.00 A; CQ/DQ=2-118 # PDB 4V9O X-ray; 2.90 A; AQ/CQ/EQ/GQ=1-118 # PDB 4V9P X-ray; 2.90 A; AQ/CQ/EQ/GQ=1-118 # PDB 4WF1 X-ray; 3.09 A; BQ/DQ=2-118 # PDB 4WOI X-ray; 3.00 A; BQ/CQ=1-118 # PDB 4WWW X-ray; 3.10 A; RQ/YQ=2-118 # PDB 4YBB X-ray; 2.10 A; CR/DR=2-118 # PDB 5ADY EM; 4.50 A; Q=1-118 # PDB 5AFI EM; 2.90 A; Q=1-118 # PDB 5AKA EM; 5.70 A; Q=2-118 # PDB 5GAD EM; 3.70 A; R=1-118 # PDB 5GAE EM; 3.33 A; R=1-118 # PDB 5GAF EM; 4.30 A; R=2-118 # PDB 5GAG EM; 3.80 A; R=1-118 # PDB 5GAH EM; 3.80 A; R=1-118 # PDB 5IQR EM; 3.00 A; Q=1-118 # PDB 5IT8 X-ray; 3.12 A; CR/DR=2-118 # PDB 5J5B X-ray; 2.80 A; CR/DR=2-118 # PDB 5J7L X-ray; 3.00 A; CR/DR=2-118 # PDB 5J88 X-ray; 3.32 A; CR/DR=2-118 # PDB 5J8A X-ray; 3.10 A; CR/DR=2-118 # PDB 5J91 X-ray; 2.96 A; CR/DR=2-118 # PDB 5JC9 X-ray; 3.03 A; CR/DR=2-118 # PDB 5JTE EM; 3.60 A; BQ=1-118 # PDB 5JU8 EM; 3.60 A; BQ=1-118 # PDB 5KCR EM; 3.60 A; 1U=1-118 # PDB 5KCS EM; 3.90 A; 1U=1-118 # PDB 5KPS EM; 3.90 A; Q=1-118 # PDB 5KPV EM; 4.10 A; P=1-118 # PDB 5KPW EM; 3.90 A; P=1-118 # PDB 5KPX EM; 3.90 A; P=1-118 # PDB 5L3P EM; 3.70 A; U=1-118 # PIR D64930 R5EC20 # PRINTS PR00062 RIBOSOMALL20 # PROSITE PS00937 RIBOSOMAL_L20 # Pfam PF00453 Ribosomal_L20 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RL20_ECOLI 50S ribosomal protein L20 # RefSeq NP_416231 NC_000913.3 # RefSeq WP_000124850 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein L20P family. {ECO 0000305}. # SUBUNIT Part of the 50S ribosomal subunit. Contacts L21 (PubMed:2665813). {ECO 0000269|PubMed:2665813}. # TIGRFAMs TIGR01032 rplT_bact # eggNOG COG0292 LUCA # eggNOG ENOG4108YZX Bacteria BLAST swissprot:RL20_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RL20_ECOLI BioCyc ECOL316407:JW1706-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1706-MONOMER BioCyc EcoCyc:EG10881-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10881-MONOMER BioCyc MetaCyc:EG10881-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10881-MONOMER COG COG0292 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0292 DIP DIP-47941N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47941N DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1016/0014-5793(79)81250-8 http://dx.doi.org/10.1016/0014-5793(79)81250-8 DOI 10.1016/0022-2836(83)90092-X http://dx.doi.org/10.1016/0022-2836(83)90092-X DOI 10.1016/0022-2836(85)90420-6 http://dx.doi.org/10.1016/0022-2836(85)90420-6 DOI 10.1016/S0092-8674(03)00427-6 http://dx.doi.org/10.1016/S0092-8674(03)00427-6 DOI 10.1016/j.celrep.2014.09.011 http://dx.doi.org/10.1016/j.celrep.2014.09.011 DOI 10.1021/bi00435a071 http://dx.doi.org/10.1021/bi00435a071 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pbio.1001866 http://dx.doi.org/10.1371/journal.pbio.1001866 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K02844 http://www.ebi.ac.uk/ena/data/view/K02844 EMBL M10423 http://www.ebi.ac.uk/ena/data/view/M10423 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00291 http://www.ebi.ac.uk/ena/data/view/V00291 EchoBASE EB0874 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0874 EcoGene EG10881 http://www.ecogene.org/geneInfo.php?eg_id=EG10881 EnsemblBacteria AAC74786 http://www.ensemblgenomes.org/id/AAC74786 EnsemblBacteria AAC74786 http://www.ensemblgenomes.org/id/AAC74786 EnsemblBacteria BAA15483 http://www.ensemblgenomes.org/id/BAA15483 EnsemblBacteria BAA15483 http://www.ensemblgenomes.org/id/BAA15483 EnsemblBacteria BAA15483 http://www.ensemblgenomes.org/id/BAA15483 EnsemblBacteria b1716 http://www.ensemblgenomes.org/id/b1716 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0022625 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022625 GO_function GO:0000900 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000900 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GO_process GO:0000027 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000027 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_process GO:0022618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022618 GeneID 945152 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945152 HAMAP MF_00382 http://hamap.expasy.org/unirule/MF_00382 HOGENOM HOG000035046 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000035046&db=HOGENOM6 InParanoid P0A7L3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7L3 IntAct P0A7L3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7L3* InterPro IPR005813 http://www.ebi.ac.uk/interpro/entry/IPR005813 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW1706 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1706 KEGG_Gene eco:b1716 http://www.genome.jp/dbget-bin/www_bget?eco:b1716 KEGG_Orthology KO:K02887 http://www.genome.jp/dbget-bin/www_bget?KO:K02887 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 MINT MINT-1321645 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1321645 OMA WIRNRGP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WIRNRGP PANTHER PTHR10986 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10986 PDB 2J28 http://www.ebi.ac.uk/pdbe-srv/view/entry/2J28 PDB 2RDO http://www.ebi.ac.uk/pdbe-srv/view/entry/2RDO PDB 3BBX http://www.ebi.ac.uk/pdbe-srv/view/entry/3BBX PDB 3J5L http://www.ebi.ac.uk/pdbe-srv/view/entry/3J5L PDB 3J7Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J7Z PDB 3J8G http://www.ebi.ac.uk/pdbe-srv/view/entry/3J8G PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 4CSU http://www.ebi.ac.uk/pdbe-srv/view/entry/4CSU PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4UY8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4UY8 PDB 4V47 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V47 PDB 4V48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V48 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5ADY http://www.ebi.ac.uk/pdbe-srv/view/entry/5ADY PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5AKA http://www.ebi.ac.uk/pdbe-srv/view/entry/5AKA PDB 5GAD http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAD PDB 5GAE http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAE PDB 5GAF http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAF PDB 5GAG http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAG PDB 5GAH http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAH PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 2J28 http://www.ebi.ac.uk/pdbsum/2J28 PDBsum 2RDO http://www.ebi.ac.uk/pdbsum/2RDO PDBsum 3BBX http://www.ebi.ac.uk/pdbsum/3BBX PDBsum 3J5L http://www.ebi.ac.uk/pdbsum/3J5L PDBsum 3J7Z http://www.ebi.ac.uk/pdbsum/3J7Z PDBsum 3J8G http://www.ebi.ac.uk/pdbsum/3J8G PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 4CSU http://www.ebi.ac.uk/pdbsum/4CSU PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4UY8 http://www.ebi.ac.uk/pdbsum/4UY8 PDBsum 4V47 http://www.ebi.ac.uk/pdbsum/4V47 PDBsum 4V48 http://www.ebi.ac.uk/pdbsum/4V48 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5ADY http://www.ebi.ac.uk/pdbsum/5ADY PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5AKA http://www.ebi.ac.uk/pdbsum/5AKA PDBsum 5GAD http://www.ebi.ac.uk/pdbsum/5GAD PDBsum 5GAE http://www.ebi.ac.uk/pdbsum/5GAE PDBsum 5GAF http://www.ebi.ac.uk/pdbsum/5GAF PDBsum 5GAG http://www.ebi.ac.uk/pdbsum/5GAG PDBsum 5GAH http://www.ebi.ac.uk/pdbsum/5GAH PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PRINTS PR00062 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00062 PROSITE PS00937 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00937 PSORT swissprot:RL20_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RL20_ECOLI PSORT-B swissprot:RL20_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RL20_ECOLI PSORT2 swissprot:RL20_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RL20_ECOLI Pfam PF00453 http://pfam.xfam.org/family/PF00453 Phobius swissprot:RL20_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RL20_ECOLI PhylomeDB P0A7L3 http://phylomedb.org/?seqid=P0A7L3 ProteinModelPortal P0A7L3 http://www.proteinmodelportal.org/query/uniprot/P0A7L3 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 12809609 http://www.ncbi.nlm.nih.gov/pubmed/12809609 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 24844575 http://www.ncbi.nlm.nih.gov/pubmed/24844575 PubMed 25310980 http://www.ncbi.nlm.nih.gov/pubmed/25310980 PubMed 2665813 http://www.ncbi.nlm.nih.gov/pubmed/2665813 PubMed 3158742 http://www.ncbi.nlm.nih.gov/pubmed/3158742 PubMed 3298242 http://www.ncbi.nlm.nih.gov/pubmed/3298242 PubMed 381019 http://www.ncbi.nlm.nih.gov/pubmed/381019 PubMed 6317865 http://www.ncbi.nlm.nih.gov/pubmed/6317865 PubMed 6397321 http://www.ncbi.nlm.nih.gov/pubmed/6397321 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416231 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416231 RefSeq WP_000124850 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000124850 SMR P0A7L3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7L3 STRING 511145.b1716 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1716&targetmode=cogs STRING COG0292 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0292&targetmode=cogs TIGRFAMs TIGR01032 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01032 UniProtKB RL20_ECOLI http://www.uniprot.org/uniprot/RL20_ECOLI UniProtKB-AC P0A7L3 http://www.uniprot.org/uniprot/P0A7L3 charge swissprot:RL20_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RL20_ECOLI eggNOG COG0292 http://eggnogapi.embl.de/nog_data/html/tree/COG0292 eggNOG ENOG4108YZX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108YZX epestfind swissprot:RL20_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RL20_ECOLI garnier swissprot:RL20_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RL20_ECOLI helixturnhelix swissprot:RL20_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RL20_ECOLI hmoment swissprot:RL20_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RL20_ECOLI iep swissprot:RL20_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RL20_ECOLI inforesidue swissprot:RL20_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RL20_ECOLI octanol swissprot:RL20_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RL20_ECOLI pepcoil swissprot:RL20_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RL20_ECOLI pepdigest swissprot:RL20_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RL20_ECOLI pepinfo swissprot:RL20_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RL20_ECOLI pepnet swissprot:RL20_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RL20_ECOLI pepstats swissprot:RL20_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RL20_ECOLI pepwheel swissprot:RL20_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RL20_ECOLI pepwindow swissprot:RL20_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RL20_ECOLI sigcleave swissprot:RL20_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RL20_ECOLI ## Database ID URL or Descriptions # BioGrid 4261149 15 # EcoGene EG13099 yqeH # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:InterPro. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # Gene3D 1.10.10.10 -; 1. # IntAct Q46941 2 # InterPro IPR000792 Tscrpt_reg_LuxR_C # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR016032 Sig_transdc_resp-reg_C-effctor # Organism YQEH_ECOLI Escherichia coli (strain K12) # PATRIC 32121110 VBIEscCol129921_2944 # Pfam PF00196 GerE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQEH_ECOLI Uncharacterized protein YqeH # RefSeq NP_417323 NC_000913.3 # RefSeq WP_001336169 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40493.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY To E.coli YkgK. {ECO 0000305}. # SUPFAM SSF46894 SSF46894 # eggNOG ENOG4105ISV Bacteria # eggNOG ENOG4111PDN LUCA BLAST swissprot:YQEH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQEH_ECOLI BioCyc ECOL316407:JW5454-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5454-MONOMER BioCyc EcoCyc:G7466-MONOMER http://biocyc.org/getid?id=EcoCyc:G7466-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 EchoBASE EB2902 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2902 EcoGene EG13099 http://www.ecogene.org/geneInfo.php?eg_id=EG13099 EnsemblBacteria AAC75885 http://www.ensemblgenomes.org/id/AAC75885 EnsemblBacteria AAC75885 http://www.ensemblgenomes.org/id/AAC75885 EnsemblBacteria BAE76915 http://www.ensemblgenomes.org/id/BAE76915 EnsemblBacteria BAE76915 http://www.ensemblgenomes.org/id/BAE76915 EnsemblBacteria BAE76915 http://www.ensemblgenomes.org/id/BAE76915 EnsemblBacteria b2846 http://www.ensemblgenomes.org/id/b2846 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 945263 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945263 HOGENOM HOG000009547 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009547&db=HOGENOM6 IntAct Q46941 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46941* InterPro IPR000792 http://www.ebi.ac.uk/interpro/entry/IPR000792 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR016032 http://www.ebi.ac.uk/interpro/entry/IPR016032 KEGG_Gene ecj:JW5454 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5454 KEGG_Gene eco:b2846 http://www.genome.jp/dbget-bin/www_bget?eco:b2846 OMA NSGMHIV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NSGMHIV PSORT swissprot:YQEH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQEH_ECOLI PSORT-B swissprot:YQEH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQEH_ECOLI PSORT2 swissprot:YQEH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQEH_ECOLI Pfam PF00196 http://pfam.xfam.org/family/PF00196 Phobius swissprot:YQEH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQEH_ECOLI ProteinModelPortal Q46941 http://www.proteinmodelportal.org/query/uniprot/Q46941 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417323 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417323 RefSeq WP_001336169 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001336169 SMR Q46941 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46941 STRING 511145.b2846 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2846&targetmode=cogs SUPFAM SSF46894 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46894 UniProtKB YQEH_ECOLI http://www.uniprot.org/uniprot/YQEH_ECOLI UniProtKB-AC Q46941 http://www.uniprot.org/uniprot/Q46941 charge swissprot:YQEH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQEH_ECOLI eggNOG ENOG4105ISV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ISV eggNOG ENOG4111PDN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111PDN epestfind swissprot:YQEH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQEH_ECOLI garnier swissprot:YQEH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQEH_ECOLI helixturnhelix swissprot:YQEH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQEH_ECOLI hmoment swissprot:YQEH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQEH_ECOLI iep swissprot:YQEH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQEH_ECOLI inforesidue swissprot:YQEH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQEH_ECOLI octanol swissprot:YQEH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQEH_ECOLI pepcoil swissprot:YQEH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQEH_ECOLI pepdigest swissprot:YQEH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQEH_ECOLI pepinfo swissprot:YQEH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQEH_ECOLI pepnet swissprot:YQEH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQEH_ECOLI pepstats swissprot:YQEH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQEH_ECOLI pepwheel swissprot:YQEH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQEH_ECOLI pepwindow swissprot:YQEH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQEH_ECOLI sigcleave swissprot:YQEH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQEH_ECOLI ## Database ID URL or Descriptions # BioGrid 4263114 6 # EcoGene EG11933 pspG # FUNCTION PSPG_ECOLI Effector of the phage shock response. {ECO 0000269|PubMed 15485810}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0009271 phage shock; IEP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006950 response to stress # GOslim_process GO:0044403 symbiosis, encompassing mutualism through parasitism # INDUCTION Up-regulated in response to filamentous phage secretin protein IV. Induced by PspF and negatively regulated by PspA. {ECO:0000269|PubMed 15485810}. # InterPro IPR014318 Phageshock_PspG # Organism PSPG_ECOLI Escherichia coli (strain K12) # PATRIC 32123639 VBIEscCol129921_4168 # PIR A65213 A65213 # Pfam PF09583 Phageshock_PspG # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PSPG_ECOLI Phage shock protein G # RefSeq NP_418474 NC_000913.3 # RefSeq WP_000891404 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAC43144.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SUBCELLULAR LOCATION PSPG_ECOLI Cell inner membrane {ECO 0000269|PubMed 19555453}; Multi-pass membrane protein {ECO 0000269|PubMed 19555453}. Note=Localizes at both cell poles and along the length of the cell. # TIGRFAMs TIGR02975 phageshock_pspG # eggNOG ENOG4105P4Z Bacteria # eggNOG ENOG411217G LUCA BLAST swissprot:PSPG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PSPG_ECOLI BioCyc ECOL316407:JW5716-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5716-MONOMER BioCyc EcoCyc:EG11933-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11933-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M408994200 http://dx.doi.org/10.1074/jbc.M408994200 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1111/j.1365-2958.2009.06776.x http://dx.doi.org/10.1111/j.1365-2958.2009.06776.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1877 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1877 EcoGene EG11933 http://www.ecogene.org/geneInfo.php?eg_id=EG11933 EnsemblBacteria AAC77020 http://www.ensemblgenomes.org/id/AAC77020 EnsemblBacteria AAC77020 http://www.ensemblgenomes.org/id/AAC77020 EnsemblBacteria BAE78052 http://www.ensemblgenomes.org/id/BAE78052 EnsemblBacteria BAE78052 http://www.ensemblgenomes.org/id/BAE78052 EnsemblBacteria BAE78052 http://www.ensemblgenomes.org/id/BAE78052 EnsemblBacteria b4050 http://www.ensemblgenomes.org/id/b4050 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0009271 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009271 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0044403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403 GeneID 948557 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948557 HOGENOM HOG000218415 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218415&db=HOGENOM6 InterPro IPR014318 http://www.ebi.ac.uk/interpro/entry/IPR014318 KEGG_Gene ecj:JW5716 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5716 KEGG_Gene eco:b4050 http://www.genome.jp/dbget-bin/www_bget?eco:b4050 OMA MFELIFI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MFELIFI PSORT swissprot:PSPG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PSPG_ECOLI PSORT-B swissprot:PSPG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PSPG_ECOLI PSORT2 swissprot:PSPG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PSPG_ECOLI Pfam PF09583 http://pfam.xfam.org/family/PF09583 Phobius swissprot:PSPG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PSPG_ECOLI ProteinModelPortal P32696 http://www.proteinmodelportal.org/query/uniprot/P32696 PubMed 15485810 http://www.ncbi.nlm.nih.gov/pubmed/15485810 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19555453 http://www.ncbi.nlm.nih.gov/pubmed/19555453 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418474 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418474 RefSeq WP_000891404 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000891404 STRING 511145.b4050 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4050&targetmode=cogs TIGRFAMs TIGR02975 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02975 UniProtKB PSPG_ECOLI http://www.uniprot.org/uniprot/PSPG_ECOLI UniProtKB-AC P32696 http://www.uniprot.org/uniprot/P32696 charge swissprot:PSPG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PSPG_ECOLI eggNOG ENOG4105P4Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105P4Z eggNOG ENOG411217G http://eggnogapi.embl.de/nog_data/html/tree/ENOG411217G epestfind swissprot:PSPG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PSPG_ECOLI garnier swissprot:PSPG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PSPG_ECOLI helixturnhelix swissprot:PSPG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PSPG_ECOLI hmoment swissprot:PSPG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PSPG_ECOLI iep swissprot:PSPG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PSPG_ECOLI inforesidue swissprot:PSPG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PSPG_ECOLI octanol swissprot:PSPG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PSPG_ECOLI pepcoil swissprot:PSPG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PSPG_ECOLI pepdigest swissprot:PSPG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PSPG_ECOLI pepinfo swissprot:PSPG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PSPG_ECOLI pepnet swissprot:PSPG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PSPG_ECOLI pepstats swissprot:PSPG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PSPG_ECOLI pepwheel swissprot:PSPG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PSPG_ECOLI pepwindow swissprot:PSPG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PSPG_ECOLI sigcleave swissprot:PSPG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PSPG_ECOLI ## Database ID URL or Descriptions # AltName K(+)/H(+) antiporter {ECO:0000255|HAMAP-Rule MF_01413} # BioGrid 4262200 7 # DOMAIN KEFC_ECOLI The cytoplasmic RCK N-terminal domain regulates channel activity. It binds glutathione, resulting in inhibition of potassium efflux. In contrast, binding of the adducts formed between glutathione and electrophiles leads to activation of potassium efflux. Is expected to bind NADH, but X-ray crystallography shows bound AMP, and it would be difficult to accommodate NADH in this binding site (PubMed 21041667). {ECO 0000269|PubMed 21041667}. # ENZYME REGULATION KEFC_ECOLI Inhibited by glutathione. This inhibition is increased by NADH. Activated by adducts between glutathione and electrophiles. {ECO 0000269|PubMed 17679694, ECO 0000269|PubMed 21041667, ECO 0000269|PubMed 9023177}. # EcoGene EG10521 kefC # FUNCTION KEFC_ECOLI Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. Can also export rubidium, lithium and sodium. {ECO 0000255|HAMAP-Rule MF_01413, ECO 0000269|PubMed 17679694, ECO 0000269|PubMed 21041667, ECO 0000269|PubMed 9023177}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoliWiki. # GO_component GO:0016020 membrane; IDA:EcoCyc. # GO_function GO:0000166 nucleotide binding; IEA:UniProtKB-KW. # GO_function GO:0015503 glutathione-regulated potassium exporter activity; IMP:EcoCyc. # GO_function GO:0015643 toxic substance binding; IDA:EcoCyc. # GO_function GO:0019899 enzyme binding; IMP:EcoCyc. # GO_function KEFC_ECOLI GO 0015299 solute proton antiporter activity; IEA InterPro. # GO_process GO:0006813 potassium ion transport; IDA:EcoliWiki. # GO_process GO:0006885 regulation of pH; IDA:EcoliWiki. # GO_process GO:0009636 response to toxic substance; IMP:EcoCyc. # GO_process GO:0051595 response to methylglyoxal; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0019899 enzyme binding # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # GOslim_process GO:0042592 homeostatic process # Gene3D 3.40.50.720 -; 1. # HAMAP MF_01413 K_H_efflux_KefC # IntAct P03819 2 # InterPro IPR003148 RCK_N # InterPro IPR004771 K/H_exchanger # InterPro IPR006036 K_uptake_TrkA # InterPro IPR006153 Cation/H_exchanger # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR023941 K_H_efflux_KefC # Organism KEFC_ECOLI Escherichia coli (strain K12) # PATRIC 32115193 VBIEscCol129921_0048 # PDB 3EYW X-ray; 2.40 A; A/B=401-620 # PDB 3L9W X-ray; 1.75 A; A/B=401-620 # PDB 3L9X X-ray; 2.10 A; A/B=401-620 # PIR S40568 QQECRD # PRINTS PR00335 KUPTAKETRKA # PROSITE PS51201 RCK_N # Pfam PF00999 Na_H_Exchanger # Pfam PF02254 TrkA_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Glutathione-regulated potassium-efflux system protein KefC {ECO:0000255|HAMAP-Rule MF_01413} # RefSeq NP_414589 NC_000913.3 # RefSeq WP_000377098 NZ_LN832404.1 # SIMILARITY Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. KefC subfamily. {ECO 0000255|HAMAP-Rule:MF_01413}. # SIMILARITY Contains 1 RCK N-terminal domain. {ECO:0000255|HAMAP- Rule MF_01413}. # SUBCELLULAR LOCATION KEFC_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01413, ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 2046548}; Multi-pass membrane protein {ECO 0000255|HAMAP-Rule MF_01413, ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 2046548}. # SUBUNIT KEFC_ECOLI Homodimer. Interacts with the regulatory subunit KefF, forming a heterotetramer with 2 2 stoichiometry. Interaction with KefF is required for optimal activity. The active antiporter may be formed by the heterotetramer, or by an octamer. {ECO 0000255|HAMAP-Rule MF_01413, ECO 0000269|PubMed 17679694, ECO 0000269|PubMed 19523906, ECO 0000269|PubMed 21041667}. # SUPFAM SSF51735 SSF51735 # TCDB 2.A.37.1:the monovalent cation proton antiporter-2 (cpa2) family # TIGRFAMs TIGR00932 2a37 # eggNOG COG0475 LUCA # eggNOG COG1226 LUCA # eggNOG ENOG4105CKD Bacteria BLAST swissprot:KEFC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:KEFC_ECOLI BioCyc ECOL316407:JW0046-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0046-MONOMER BioCyc EcoCyc:KEFC-MONOMER http://biocyc.org/getid?id=EcoCyc:KEFC-MONOMER BioCyc MetaCyc:KEFC-MONOMER http://biocyc.org/getid?id=MetaCyc:KEFC-MONOMER COG COG0475 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0475 COG COG1226 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1226 DIP DIP-10072N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10072N DOI 10.1016/0378-1097(92)90601-J http://dx.doi.org/10.1016/0378-1097(92)90601-J DOI 10.1016/j.str.2009.03.018 http://dx.doi.org/10.1016/j.str.2009.03.018 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0703709104 http://dx.doi.org/10.1073/pnas.0703709104 DOI 10.1073/pnas.1012716107 http://dx.doi.org/10.1073/pnas.1012716107 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1093/nar/8.10.2255 http://dx.doi.org/10.1093/nar/8.10.2255 DOI 10.1111/j.1365-2958.1991.tb00731.x http://dx.doi.org/10.1111/j.1365-2958.1991.tb00731.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01609 http://www.ebi.ac.uk/ena/data/view/J01609 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X56742 http://www.ebi.ac.uk/ena/data/view/X56742 EchoBASE EB0516 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0516 EcoGene EG10521 http://www.ecogene.org/geneInfo.php?eg_id=EG10521 EnsemblBacteria AAC73158 http://www.ensemblgenomes.org/id/AAC73158 EnsemblBacteria AAC73158 http://www.ensemblgenomes.org/id/AAC73158 EnsemblBacteria BAB96615 http://www.ensemblgenomes.org/id/BAB96615 EnsemblBacteria BAB96615 http://www.ensemblgenomes.org/id/BAB96615 EnsemblBacteria BAB96615 http://www.ensemblgenomes.org/id/BAB96615 EnsemblBacteria b0047 http://www.ensemblgenomes.org/id/b0047 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0000166 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000166 GO_function GO:0015299 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015299 GO_function GO:0015503 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015503 GO_function GO:0015643 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015643 GO_function GO:0019899 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899 GO_process GO:0006813 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813 GO_process GO:0006885 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006885 GO_process GO:0009636 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009636 GO_process GO:0051595 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051595 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0019899 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 944773 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944773 HAMAP MF_01413 http://hamap.expasy.org/unirule/MF_01413 HOGENOM HOG000179076 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000179076&db=HOGENOM6 InParanoid P03819 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P03819 IntAct P03819 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P03819* InterPro IPR003148 http://www.ebi.ac.uk/interpro/entry/IPR003148 InterPro IPR004771 http://www.ebi.ac.uk/interpro/entry/IPR004771 InterPro IPR006036 http://www.ebi.ac.uk/interpro/entry/IPR006036 InterPro IPR006153 http://www.ebi.ac.uk/interpro/entry/IPR006153 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR023941 http://www.ebi.ac.uk/interpro/entry/IPR023941 KEGG_Gene ecj:JW0046 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0046 KEGG_Gene eco:b0047 http://www.genome.jp/dbget-bin/www_bget?eco:b0047 KEGG_Orthology KO:K11745 http://www.genome.jp/dbget-bin/www_bget?KO:K11745 MINT MINT-1257196 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1257196 OMA RNRRHAY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RNRRHAY PDB 3EYW http://www.ebi.ac.uk/pdbe-srv/view/entry/3EYW PDB 3L9W http://www.ebi.ac.uk/pdbe-srv/view/entry/3L9W PDB 3L9X http://www.ebi.ac.uk/pdbe-srv/view/entry/3L9X PDBsum 3EYW http://www.ebi.ac.uk/pdbsum/3EYW PDBsum 3L9W http://www.ebi.ac.uk/pdbsum/3L9W PDBsum 3L9X http://www.ebi.ac.uk/pdbsum/3L9X PRINTS PR00335 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00335 PROSITE PS51201 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51201 PSORT swissprot:KEFC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:KEFC_ECOLI PSORT-B swissprot:KEFC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:KEFC_ECOLI PSORT2 swissprot:KEFC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:KEFC_ECOLI Pfam PF00999 http://pfam.xfam.org/family/PF00999 Pfam PF02254 http://pfam.xfam.org/family/PF02254 Phobius swissprot:KEFC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:KEFC_ECOLI PhylomeDB P03819 http://phylomedb.org/?seqid=P03819 ProteinModelPortal P03819 http://www.proteinmodelportal.org/query/uniprot/P03819 PubMed 1325937 http://www.ncbi.nlm.nih.gov/pubmed/1325937 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17679694 http://www.ncbi.nlm.nih.gov/pubmed/17679694 PubMed 19523906 http://www.ncbi.nlm.nih.gov/pubmed/19523906 PubMed 2046548 http://www.ncbi.nlm.nih.gov/pubmed/2046548 PubMed 21041667 http://www.ncbi.nlm.nih.gov/pubmed/21041667 PubMed 6159575 http://www.ncbi.nlm.nih.gov/pubmed/6159575 PubMed 9023177 http://www.ncbi.nlm.nih.gov/pubmed/9023177 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414589 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414589 RefSeq WP_000377098 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000377098 SMR P03819 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P03819 STRING 511145.b0047 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0047&targetmode=cogs STRING COG0475 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0475&targetmode=cogs STRING COG1226 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1226&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 TCDB 2.A.37.1 http://www.tcdb.org/search/result.php?tc=2.A.37.1 TIGRFAMs TIGR00932 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00932 UniProtKB KEFC_ECOLI http://www.uniprot.org/uniprot/KEFC_ECOLI UniProtKB-AC P03819 http://www.uniprot.org/uniprot/P03819 charge swissprot:KEFC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:KEFC_ECOLI eggNOG COG0475 http://eggnogapi.embl.de/nog_data/html/tree/COG0475 eggNOG COG1226 http://eggnogapi.embl.de/nog_data/html/tree/COG1226 eggNOG ENOG4105CKD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CKD epestfind swissprot:KEFC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:KEFC_ECOLI garnier swissprot:KEFC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:KEFC_ECOLI helixturnhelix swissprot:KEFC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:KEFC_ECOLI hmoment swissprot:KEFC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:KEFC_ECOLI iep swissprot:KEFC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:KEFC_ECOLI inforesidue swissprot:KEFC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:KEFC_ECOLI octanol swissprot:KEFC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:KEFC_ECOLI pepcoil swissprot:KEFC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:KEFC_ECOLI pepdigest swissprot:KEFC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:KEFC_ECOLI pepinfo swissprot:KEFC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:KEFC_ECOLI pepnet swissprot:KEFC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:KEFC_ECOLI pepstats swissprot:KEFC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:KEFC_ECOLI pepwheel swissprot:KEFC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:KEFC_ECOLI pepwindow swissprot:KEFC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:KEFC_ECOLI sigcleave swissprot:KEFC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:KEFC_ECOLI ## Database ID URL or Descriptions # AltName HEM2_ECOLI Porphobilinogen synthase # BRENDA 4.2.1.24 2026 # CATALYTIC ACTIVITY HEM2_ECOLI 2 5-aminolevulinate = porphobilinogen + 2 H(2)O. # COFACTOR HEM2_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 10194344, ECO 0000269|PubMed 11444968, ECO 0000269|PubMed 11909869, ECO 0000269|PubMed 7592604}; Note=Binds 1 zinc ion per monomer. {ECO 0000269|PubMed 10194344, ECO 0000269|PubMed 11444968, ECO 0000269|PubMed 11909869, ECO 0000269|PubMed 7592604}; # ENZYME REGULATION Allosteric enzyme. Stimulated by magnesium ions. {ECO:0000269|PubMed 7592604}. # EcoGene EG10428 hemB # FUNCTION HEM2_ECOLI Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0004655 porphobilinogen synthase activity; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IDA:EcoCyc. # GO_process GO:0006782 protoporphyrinogen IX biosynthetic process; IDA:EcoCyc. # GO_process GO:0006783 heme biosynthetic process; IMP:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.20.20.70 -; 1. # IntAct P0ACB2 6 # InterPro IPR001731 ALAD # InterPro IPR013785 Aldolase_TIM # InterPro IPR030656 ALAD_AS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00860 Porphyrin and chlorophyll metabolism # Organism HEM2_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11458 PTHR11458 # PATHWAY Porphyrin-containing compound metabolism; protoporphyrin- IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate step 1/4. # PATRIC 32115877 VBIEscCol129921_0380 # PDB 1B4E X-ray; 2.00 A; A=2-324 # PDB 1I8J X-ray; 1.90 A; A/B=2-324 # PDB 1L6S X-ray; 1.70 A; A/B=2-324 # PDB 1L6Y X-ray; 1.90 A; A/B=2-324 # PDB 5IC2 X-ray; 2.10 A; A=1-324 # PIR A64765 SYECPF # PIRSF PIRSF001415 Porphbilin_synth # PRINTS PR00144 DALDHYDRTASE # PROSITE PS00169 D_ALA_DEHYDRATASE # Pfam PF00490 ALAD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HEM2_ECOLI Delta-aminolevulinic acid dehydratase # RefSeq NP_414903 NC_000913.3 # RefSeq WP_001295337 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18092.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA12842.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ALAD family. {ECO 0000305}. # SMART SM01004 ALAD # SUBUNIT HEM2_ECOLI Homooctamer. {ECO 0000269|PubMed 10194344, ECO 0000269|PubMed 11444968, ECO 0000269|PubMed 11909869}. # UniPathway UPA00251 UER00318 # eggNOG COG0113 LUCA # eggNOG ENOG4105D52 Bacteria BLAST swissprot:HEM2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HEM2_ECOLI BioCyc ECOL316407:JW0361-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0361-MONOMER BioCyc EcoCyc:PORPHOBILSYNTH-MONOMER http://biocyc.org/getid?id=EcoCyc:PORPHOBILSYNTH-MONOMER BioCyc MetaCyc:PORPHOBILSYNTH-MONOMER http://biocyc.org/getid?id=MetaCyc:PORPHOBILSYNTH-MONOMER COG COG0113 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0113 DIP DIP-36209N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36209N DOI 10.1007/BF00330487 http://dx.doi.org/10.1007/BF00330487 DOI 10.1016/0378-1119(89)90394-6 http://dx.doi.org/10.1016/0378-1119(89)90394-6 DOI 10.1021/bi010656k http://dx.doi.org/10.1021/bi010656k DOI 10.1021/bi982137w http://dx.doi.org/10.1021/bi982137w DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2900279 http://dx.doi.org/10.1042/bj2900279 DOI 10.1074/jbc.270.41.24054 http://dx.doi.org/10.1074/jbc.270.41.24054 DOI 10.1074/jbc.M201486200 http://dx.doi.org/10.1074/jbc.M201486200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.1.24 http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.24 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D85613 http://www.ebi.ac.uk/ena/data/view/D85613 EMBL L44595 http://www.ebi.ac.uk/ena/data/view/L44595 EMBL M24488 http://www.ebi.ac.uk/ena/data/view/M24488 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EMBL X17417 http://www.ebi.ac.uk/ena/data/view/X17417 ENZYME 4.2.1.24 http://enzyme.expasy.org/EC/4.2.1.24 EchoBASE EB0423 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0423 EcoGene EG10428 http://www.ecogene.org/geneInfo.php?eg_id=EG10428 EnsemblBacteria AAC73472 http://www.ensemblgenomes.org/id/AAC73472 EnsemblBacteria AAC73472 http://www.ensemblgenomes.org/id/AAC73472 EnsemblBacteria BAE76150 http://www.ensemblgenomes.org/id/BAE76150 EnsemblBacteria BAE76150 http://www.ensemblgenomes.org/id/BAE76150 EnsemblBacteria BAE76150 http://www.ensemblgenomes.org/id/BAE76150 EnsemblBacteria b0369 http://www.ensemblgenomes.org/id/b0369 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004655 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006782 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006782 GO_process GO:0006783 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006783 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 945017 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945017 HOGENOM HOG000020323 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000020323&db=HOGENOM6 InParanoid P0ACB2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACB2 IntAct P0ACB2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACB2* IntEnz 4.2.1.24 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.24 InterPro IPR001731 http://www.ebi.ac.uk/interpro/entry/IPR001731 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR030656 http://www.ebi.ac.uk/interpro/entry/IPR030656 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0361 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0361 KEGG_Gene eco:b0369 http://www.genome.jp/dbget-bin/www_bget?eco:b0369 KEGG_Orthology KO:K01698 http://www.genome.jp/dbget-bin/www_bget?KO:K01698 KEGG_Pathway ko00860 http://www.genome.jp/kegg-bin/show_pathway?ko00860 KEGG_Reaction rn:R00036 http://www.genome.jp/dbget-bin/www_bget?rn:R00036 MINT MINT-6765615 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-6765615 OMA ISYHAKE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ISYHAKE PANTHER PTHR11458 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11458 PDB 1B4E http://www.ebi.ac.uk/pdbe-srv/view/entry/1B4E PDB 1I8J http://www.ebi.ac.uk/pdbe-srv/view/entry/1I8J PDB 1L6S http://www.ebi.ac.uk/pdbe-srv/view/entry/1L6S PDB 1L6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/1L6Y PDB 5IC2 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IC2 PDBsum 1B4E http://www.ebi.ac.uk/pdbsum/1B4E PDBsum 1I8J http://www.ebi.ac.uk/pdbsum/1I8J PDBsum 1L6S http://www.ebi.ac.uk/pdbsum/1L6S PDBsum 1L6Y http://www.ebi.ac.uk/pdbsum/1L6Y PDBsum 5IC2 http://www.ebi.ac.uk/pdbsum/5IC2 PRINTS PR00144 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00144 PROSITE PS00169 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00169 PSORT swissprot:HEM2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HEM2_ECOLI PSORT-B swissprot:HEM2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HEM2_ECOLI PSORT2 swissprot:HEM2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HEM2_ECOLI Pfam PF00490 http://pfam.xfam.org/family/PF00490 Phobius swissprot:HEM2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HEM2_ECOLI PhylomeDB P0ACB2 http://phylomedb.org/?seqid=P0ACB2 ProteinModelPortal P0ACB2 http://www.proteinmodelportal.org/query/uniprot/P0ACB2 PubMed 10194344 http://www.ncbi.nlm.nih.gov/pubmed/10194344 PubMed 11444968 http://www.ncbi.nlm.nih.gov/pubmed/11444968 PubMed 11909869 http://www.ncbi.nlm.nih.gov/pubmed/11909869 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2464127 http://www.ncbi.nlm.nih.gov/pubmed/2464127 PubMed 2656410 http://www.ncbi.nlm.nih.gov/pubmed/2656410 PubMed 7592604 http://www.ncbi.nlm.nih.gov/pubmed/7592604 PubMed 8439296 http://www.ncbi.nlm.nih.gov/pubmed/8439296 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414903 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414903 RefSeq WP_001295337 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295337 SMART SM01004 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01004 SMR P0ACB2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACB2 STRING 511145.b0369 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0369&targetmode=cogs STRING COG0113 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0113&targetmode=cogs SWISS-2DPAGE P0ACB2 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0ACB2 UniProtKB HEM2_ECOLI http://www.uniprot.org/uniprot/HEM2_ECOLI UniProtKB-AC P0ACB2 http://www.uniprot.org/uniprot/P0ACB2 charge swissprot:HEM2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HEM2_ECOLI eggNOG COG0113 http://eggnogapi.embl.de/nog_data/html/tree/COG0113 eggNOG ENOG4105D52 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D52 epestfind swissprot:HEM2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HEM2_ECOLI garnier swissprot:HEM2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HEM2_ECOLI helixturnhelix swissprot:HEM2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HEM2_ECOLI hmoment swissprot:HEM2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HEM2_ECOLI iep swissprot:HEM2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HEM2_ECOLI inforesidue swissprot:HEM2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HEM2_ECOLI octanol swissprot:HEM2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HEM2_ECOLI pepcoil swissprot:HEM2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HEM2_ECOLI pepdigest swissprot:HEM2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HEM2_ECOLI pepinfo swissprot:HEM2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HEM2_ECOLI pepnet swissprot:HEM2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HEM2_ECOLI pepstats swissprot:HEM2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HEM2_ECOLI pepwheel swissprot:HEM2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HEM2_ECOLI pepwindow swissprot:HEM2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HEM2_ECOLI sigcleave swissprot:HEM2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HEM2_ECOLI ## Database ID URL or Descriptions # BioGrid 4259899 380 # EcoGene EG10295 fepC # FUNCTION FEPC_ECOLI Part of the binding-protein-dependent transport system for ferric enterobactin. Probably responsible for energy coupling to the transport system. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; NAS:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016887 ATPase activity; IEA:InterPro. # GO_process GO:0006811 ion transport; IEA:UniProtKB-KW. # GO_process GO:0055072 iron ion homeostasis; IEA:UniProtKB-KW. # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # GOslim_process GO:0042592 homeostatic process # Gene3D 3.40.50.300 -; 1. # INDUCTION Induced 1.5-fold by hydroxyurea. {ECO:0000269|PubMed 20005847}. # IntAct P23878 14 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00240 Iron complex transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism FEPC_ECOLI Escherichia coli (strain K12) # PATRIC 32116352 VBIEscCol129921_0616 # PIR B64792 B64792 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # Pfam PF00005 ABC_tran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FEPC_ECOLI Ferric enterobactin transport ATP-binding protein FepC # RefSeq NP_415120 NC_000913.3 # RefSeq WP_000140647 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40787.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ABC transporter superfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA # SUBCELLULAR LOCATION FEPC_ECOLI Cell inner membrane {ECO 0000305}; Peripheral membrane protein {ECO 0000305}. # SUPFAM SSF52540 SSF52540 # TCDB 3.A.1.14 the atp-binding cassette (abc) superfamily # eggNOG COG1120 LUCA # eggNOG ENOG4105E0A Bacteria BLAST swissprot:FEPC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FEPC_ECOLI BioCyc ECOL316407:JW0580-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0580-MONOMER BioCyc EcoCyc:FEPC-MONOMER http://biocyc.org/getid?id=EcoCyc:FEPC-MONOMER BioCyc MetaCyc:FEPC-MONOMER http://biocyc.org/getid?id=MetaCyc:FEPC-MONOMER COG COG1120 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1120 DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1991.tb00788.x http://dx.doi.org/10.1111/j.1365-2958.1991.tb00788.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EMBL X57471 http://www.ebi.ac.uk/ena/data/view/X57471 EchoBASE EB0291 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0291 EcoGene EG10295 http://www.ecogene.org/geneInfo.php?eg_id=EG10295 EnsemblBacteria AAC73689 http://www.ensemblgenomes.org/id/AAC73689 EnsemblBacteria AAC73689 http://www.ensemblgenomes.org/id/AAC73689 EnsemblBacteria BAE76343 http://www.ensemblgenomes.org/id/BAE76343 EnsemblBacteria BAE76343 http://www.ensemblgenomes.org/id/BAE76343 EnsemblBacteria BAE76343 http://www.ensemblgenomes.org/id/BAE76343 EnsemblBacteria b0588 http://www.ensemblgenomes.org/id/b0588 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_process GO:0006811 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811 GO_process GO:0055072 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055072 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945201 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945201 InParanoid P23878 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23878 IntAct P23878 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P23878* InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0580 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0580 KEGG_Gene eco:b0588 http://www.genome.jp/dbget-bin/www_bget?eco:b0588 KEGG_Orthology KO:K02013 http://www.genome.jp/dbget-bin/www_bget?KO:K02013 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA PCRVIDD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PCRVIDD PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:FEPC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FEPC_ECOLI PSORT-B swissprot:FEPC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FEPC_ECOLI PSORT2 swissprot:FEPC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FEPC_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Phobius swissprot:FEPC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FEPC_ECOLI PhylomeDB P23878 http://phylomedb.org/?seqid=P23878 ProteinModelPortal P23878 http://www.proteinmodelportal.org/query/uniprot/P23878 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1838574 http://www.ncbi.nlm.nih.gov/pubmed/1838574 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415120 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415120 RefSeq WP_000140647 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000140647 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P23878 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P23878 STRING 511145.b0588 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0588&targetmode=cogs STRING COG1120 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1120&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.14 http://www.tcdb.org/search/result.php?tc=3.A.1.14 UniProtKB FEPC_ECOLI http://www.uniprot.org/uniprot/FEPC_ECOLI UniProtKB-AC P23878 http://www.uniprot.org/uniprot/P23878 charge swissprot:FEPC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FEPC_ECOLI eggNOG COG1120 http://eggnogapi.embl.de/nog_data/html/tree/COG1120 eggNOG ENOG4105E0A http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E0A epestfind swissprot:FEPC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FEPC_ECOLI garnier swissprot:FEPC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FEPC_ECOLI helixturnhelix swissprot:FEPC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FEPC_ECOLI hmoment swissprot:FEPC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FEPC_ECOLI iep swissprot:FEPC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FEPC_ECOLI inforesidue swissprot:FEPC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FEPC_ECOLI octanol swissprot:FEPC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FEPC_ECOLI pepcoil swissprot:FEPC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FEPC_ECOLI pepdigest swissprot:FEPC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FEPC_ECOLI pepinfo swissprot:FEPC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FEPC_ECOLI pepnet swissprot:FEPC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FEPC_ECOLI pepstats swissprot:FEPC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FEPC_ECOLI pepwheel swissprot:FEPC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FEPC_ECOLI pepwindow swissprot:FEPC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FEPC_ECOLI sigcleave swissprot:FEPC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FEPC_ECOLI ## Database ID URL or Descriptions # BioGrid 4263401 7 # DISRUPTION PHENOTYPE Mutation confers sensitivity to SDS-EDTA and leads to accumulation of phospholipid in the outer leaflet of the outer membrane. {ECO:0000269|PubMed 19383799}. # EcoGene EG12801 mlaF # FUNCTION MLAF_ECOLI Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. Probably responsible for energy coupling to the transport system. {ECO 0000269|PubMed 19383799}. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IMP:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0005548 phospholipid transporter activity; IMP:EcoCyc. # GO_function GO:0016887 ATPase activity; IEA:InterPro. # GO_process GO:0015914 phospholipid transport; IMP:EcoCyc. # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # Gene3D 3.40.50.300 -; 1. # INTERACTION MLAF_ECOLI P0A6F5 groL; NbExp=3; IntAct=EBI-561408, EBI-543750; # IntAct P63386 8 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00210 Putative ABC transport system # KEGG_Brite ko02000 Transporters # Organism MLAF_ECOLI Escherichia coli (strain K12) # PATRIC 32121810 VBIEscCol129921_3289 # PIR E65110 E65110 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # Pfam PF00005 ABC_tran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Probable phospholipid import ATP-binding protein MlaF {ECO 0000305} # RefSeq NP_417662 NC_000913.3 # RefSeq WP_000438245 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. MlaF family. {ECO 0000305}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA # SUBCELLULAR LOCATION MLAF_ECOLI Cell inner membrane {ECO 0000305|PubMed 19383799}; Peripheral membrane protein {ECO 0000305|PubMed 19383799}; Cytoplasmic side {ECO 0000305|PubMed 19383799}. # SUBUNIT The complex is composed of two ATP-binding proteins (MlaF), two transmembrane proteins (MlaE), two cytoplasmic solute- binding proteins (MlaB) and a periplamic solute-binding protein (MlaD). {ECO:0000305|PubMed 19383799}. # SUPFAM SSF52540 SSF52540 # TCDB 3.A.1.27 the atp-binding cassette (abc) superfamily # eggNOG COG1127 LUCA # eggNOG ENOG4105DHJ Bacteria BLAST swissprot:MLAF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MLAF_ECOLI BioCyc ECOL316407:JW3162-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3162-MONOMER BioCyc EcoCyc:YRBF-MONOMER http://biocyc.org/getid?id=EcoCyc:YRBF-MONOMER COG COG1127 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1127 DIP DIP-35865N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35865N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0903229106 http://dx.doi.org/10.1073/pnas.0903229106 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.3.- {ECO:0000305|PubMed:19383799} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.- {ECO:0000305|PubMed:19383799} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 3.6.3.- {ECO:0000305|PubMed:19383799} http://enzyme.expasy.org/EC/3.6.3.- {ECO:0000305|PubMed:19383799} EchoBASE EB2653 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2653 EcoGene EG12801 http://www.ecogene.org/geneInfo.php?eg_id=EG12801 EnsemblBacteria AAC76227 http://www.ensemblgenomes.org/id/AAC76227 EnsemblBacteria AAC76227 http://www.ensemblgenomes.org/id/AAC76227 EnsemblBacteria BAE77239 http://www.ensemblgenomes.org/id/BAE77239 EnsemblBacteria BAE77239 http://www.ensemblgenomes.org/id/BAE77239 EnsemblBacteria BAE77239 http://www.ensemblgenomes.org/id/BAE77239 EnsemblBacteria b3195 http://www.ensemblgenomes.org/id/b3195 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0005548 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005548 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_process GO:0015914 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015914 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947729 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947729 InParanoid P63386 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P63386 IntAct P63386 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P63386* IntEnz 3.6.3.- {ECO:0000305|PubMed:19383799} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.- {ECO:0000305|PubMed:19383799} InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3162 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3162 KEGG_Gene eco:b3195 http://www.genome.jp/dbget-bin/www_bget?eco:b3195 KEGG_Orthology KO:K02065 http://www.genome.jp/dbget-bin/www_bget?KO:K02065 MINT MINT-1228070 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1228070 OMA IRSIVLM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IRSIVLM PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:MLAF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MLAF_ECOLI PSORT-B swissprot:MLAF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MLAF_ECOLI PSORT2 swissprot:MLAF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MLAF_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Phobius swissprot:MLAF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MLAF_ECOLI PhylomeDB P63386 http://phylomedb.org/?seqid=P63386 ProteinModelPortal P63386 http://www.proteinmodelportal.org/query/uniprot/P63386 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19383799 http://www.ncbi.nlm.nih.gov/pubmed/19383799 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417662 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417662 RefSeq WP_000438245 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000438245 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P63386 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P63386 STRING 511145.b3195 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3195&targetmode=cogs STRING COG1127 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1127&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.27 http://www.tcdb.org/search/result.php?tc=3.A.1.27 UniProtKB MLAF_ECOLI http://www.uniprot.org/uniprot/MLAF_ECOLI UniProtKB-AC P63386 http://www.uniprot.org/uniprot/P63386 charge swissprot:MLAF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MLAF_ECOLI eggNOG COG1127 http://eggnogapi.embl.de/nog_data/html/tree/COG1127 eggNOG ENOG4105DHJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DHJ epestfind swissprot:MLAF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MLAF_ECOLI garnier swissprot:MLAF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MLAF_ECOLI helixturnhelix swissprot:MLAF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MLAF_ECOLI hmoment swissprot:MLAF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MLAF_ECOLI iep swissprot:MLAF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MLAF_ECOLI inforesidue swissprot:MLAF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MLAF_ECOLI octanol swissprot:MLAF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MLAF_ECOLI pepcoil swissprot:MLAF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MLAF_ECOLI pepdigest swissprot:MLAF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MLAF_ECOLI pepinfo swissprot:MLAF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MLAF_ECOLI pepnet swissprot:MLAF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MLAF_ECOLI pepstats swissprot:MLAF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MLAF_ECOLI pepwheel swissprot:MLAF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MLAF_ECOLI pepwindow swissprot:MLAF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MLAF_ECOLI sigcleave swissprot:MLAF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MLAF_ECOLI ## Database ID URL or Descriptions # BioGrid 4263506 15 # CDD cd07178 terB_like_YebE # EcoGene EG11806 yebE # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # Gene3D 1.10.3680.10 -; 1. # IntAct P33218 5 # InterPro IPR007486 YebE # InterPro IPR029024 TerB-like # Organism YEBE_ECOLI Escherichia coli (strain K12) # PATRIC 32119013 VBIEscCol129921_1924 # PIR F64946 F64946 # Pfam PF04391 DUF533 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEBE_ECOLI Inner membrane protein YebE # RefSeq NP_416360 NC_000913.3 # RefSeq WP_000024757 NZ_LN832404.1 # SUBCELLULAR LOCATION YEBE_ECOLI Cell inner membrane; Single-pass membrane protein. # SUPFAM SSF158682 SSF158682 # eggNOG COG2979 LUCA # eggNOG ENOG4108Q2J Bacteria BLAST swissprot:YEBE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEBE_ECOLI BioCyc ECOL316407:JW1835-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1835-MONOMER BioCyc EcoCyc:EG11806-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11806-MONOMER DIP DIP-11808N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11808N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L20897 http://www.ebi.ac.uk/ena/data/view/L20897 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U26598 http://www.ebi.ac.uk/ena/data/view/U26598 EchoBASE EB1754 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1754 EcoGene EG11806 http://www.ecogene.org/geneInfo.php?eg_id=EG11806 EnsemblBacteria AAC74916 http://www.ensemblgenomes.org/id/AAC74916 EnsemblBacteria AAC74916 http://www.ensemblgenomes.org/id/AAC74916 EnsemblBacteria BAA15652 http://www.ensemblgenomes.org/id/BAA15652 EnsemblBacteria BAA15652 http://www.ensemblgenomes.org/id/BAA15652 EnsemblBacteria BAA15652 http://www.ensemblgenomes.org/id/BAA15652 EnsemblBacteria b1846 http://www.ensemblgenomes.org/id/b1846 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 Gene3D 1.10.3680.10 http://www.cathdb.info/version/latest/superfamily/1.10.3680.10 GeneID 946355 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946355 HOGENOM HOG000275691 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275691&db=HOGENOM6 InParanoid P33218 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33218 IntAct P33218 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33218* InterPro IPR007486 http://www.ebi.ac.uk/interpro/entry/IPR007486 InterPro IPR029024 http://www.ebi.ac.uk/interpro/entry/IPR029024 KEGG_Gene ecj:JW1835 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1835 KEGG_Gene eco:b1846 http://www.genome.jp/dbget-bin/www_bget?eco:b1846 OMA SCAAIDV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SCAAIDV PSORT swissprot:YEBE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEBE_ECOLI PSORT-B swissprot:YEBE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEBE_ECOLI PSORT2 swissprot:YEBE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEBE_ECOLI Pfam PF04391 http://pfam.xfam.org/family/PF04391 Phobius swissprot:YEBE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEBE_ECOLI ProteinModelPortal P33218 http://www.proteinmodelportal.org/query/uniprot/P33218 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416360 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416360 RefSeq WP_000024757 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000024757 SMR P33218 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33218 STRING 511145.b1846 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1846&targetmode=cogs SUPFAM SSF158682 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF158682 UniProtKB YEBE_ECOLI http://www.uniprot.org/uniprot/YEBE_ECOLI UniProtKB-AC P33218 http://www.uniprot.org/uniprot/P33218 charge swissprot:YEBE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEBE_ECOLI eggNOG COG2979 http://eggnogapi.embl.de/nog_data/html/tree/COG2979 eggNOG ENOG4108Q2J http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Q2J epestfind swissprot:YEBE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEBE_ECOLI garnier swissprot:YEBE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEBE_ECOLI helixturnhelix swissprot:YEBE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEBE_ECOLI hmoment swissprot:YEBE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEBE_ECOLI iep swissprot:YEBE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEBE_ECOLI inforesidue swissprot:YEBE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEBE_ECOLI octanol swissprot:YEBE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEBE_ECOLI pepcoil swissprot:YEBE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEBE_ECOLI pepdigest swissprot:YEBE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEBE_ECOLI pepinfo swissprot:YEBE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEBE_ECOLI pepnet swissprot:YEBE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEBE_ECOLI pepstats swissprot:YEBE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEBE_ECOLI pepwheel swissprot:YEBE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEBE_ECOLI pepwindow swissprot:YEBE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEBE_ECOLI sigcleave swissprot:YEBE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEBE_ECOLI ## Database ID URL or Descriptions # BioGrid 4260306 423 # COFACTOR YDJJ_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000250}; Note=Binds 2 Zn(2+) ions per subunit. {ECO 0000250}; # EcoGene EG13486 ydjJ # GO_function GO:0008270 zinc ion binding; IEA:InterPro. # GO_function GO:0016491 oxidoreductase activity; IEA:UniProtKB-KW. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.720 -; 1. # Gene3D 3.90.180.10 -; 1. # IntAct P77280 9 # InterPro IPR002085 ADH_SF_Zn-type # InterPro IPR002328 ADH_Zn_CS # InterPro IPR011032 GroES-like # InterPro IPR013149 ADH_C # InterPro IPR013154 ADH_N # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR020843 PKS_ER # Organism YDJJ_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11695 PTHR11695 # PATRIC 32118859 VBIEscCol129921_1847 # PIR F64937 F64937 # PROSITE PS00059 ADH_ZINC # Pfam PF00107 ADH_zinc_N # Pfam PF08240 ADH_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDJJ_ECOLI Uncharacterized zinc-type alcohol dehydrogenase-like protein YdjJ # RefSeq NP_416288 NC_000913.3 # RefSeq WP_000798110 NZ_LN832404.1 # SIMILARITY Belongs to the zinc-containing alcohol dehydrogenase family. {ECO 0000305}. # SMART SM00829 PKS_ER # SUPFAM SSF50129 SSF50129 # SUPFAM SSF51735 SSF51735 # eggNOG COG1063 LUCA # eggNOG ENOG4105CPQ Bacteria BLAST swissprot:YDJJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDJJ_ECOLI BioCyc ECOL316407:JW1763-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1763-MONOMER BioCyc EcoCyc:G6961-MONOMER http://biocyc.org/getid?id=EcoCyc:G6961-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- EchoBASE EB3259 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3259 EcoGene EG13486 http://www.ecogene.org/geneInfo.php?eg_id=EG13486 EnsemblBacteria AAC74844 http://www.ensemblgenomes.org/id/AAC74844 EnsemblBacteria AAC74844 http://www.ensemblgenomes.org/id/AAC74844 EnsemblBacteria BAA15572 http://www.ensemblgenomes.org/id/BAA15572 EnsemblBacteria BAA15572 http://www.ensemblgenomes.org/id/BAA15572 EnsemblBacteria BAA15572 http://www.ensemblgenomes.org/id/BAA15572 EnsemblBacteria b1774 http://www.ensemblgenomes.org/id/b1774 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 Gene3D 3.90.180.10 http://www.cathdb.info/version/latest/superfamily/3.90.180.10 GeneID 946292 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946292 HOGENOM HOG000294670 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000294670&db=HOGENOM6 InParanoid P77280 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77280 IntAct P77280 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77280* IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR002085 http://www.ebi.ac.uk/interpro/entry/IPR002085 InterPro IPR002328 http://www.ebi.ac.uk/interpro/entry/IPR002328 InterPro IPR011032 http://www.ebi.ac.uk/interpro/entry/IPR011032 InterPro IPR013149 http://www.ebi.ac.uk/interpro/entry/IPR013149 InterPro IPR013154 http://www.ebi.ac.uk/interpro/entry/IPR013154 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR020843 http://www.ebi.ac.uk/interpro/entry/IPR020843 KEGG_Gene ecj:JW1763 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1763 KEGG_Gene eco:b1774 http://www.genome.jp/dbget-bin/www_bget?eco:b1774 OMA MHNTREI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MHNTREI PANTHER PTHR11695 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11695 PROSITE PS00059 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00059 PSORT swissprot:YDJJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDJJ_ECOLI PSORT-B swissprot:YDJJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDJJ_ECOLI PSORT2 swissprot:YDJJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDJJ_ECOLI Pfam PF00107 http://pfam.xfam.org/family/PF00107 Pfam PF08240 http://pfam.xfam.org/family/PF08240 Phobius swissprot:YDJJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDJJ_ECOLI PhylomeDB P77280 http://phylomedb.org/?seqid=P77280 ProteinModelPortal P77280 http://www.proteinmodelportal.org/query/uniprot/P77280 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416288 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416288 RefSeq WP_000798110 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000798110 SMART SM00829 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00829 SMR P77280 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77280 STRING 511145.b1774 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1774&targetmode=cogs SUPFAM SSF50129 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50129 SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB YDJJ_ECOLI http://www.uniprot.org/uniprot/YDJJ_ECOLI UniProtKB-AC P77280 http://www.uniprot.org/uniprot/P77280 charge swissprot:YDJJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDJJ_ECOLI eggNOG COG1063 http://eggnogapi.embl.de/nog_data/html/tree/COG1063 eggNOG ENOG4105CPQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CPQ epestfind swissprot:YDJJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDJJ_ECOLI garnier swissprot:YDJJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDJJ_ECOLI helixturnhelix swissprot:YDJJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDJJ_ECOLI hmoment swissprot:YDJJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDJJ_ECOLI iep swissprot:YDJJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDJJ_ECOLI inforesidue swissprot:YDJJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDJJ_ECOLI octanol swissprot:YDJJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDJJ_ECOLI pepcoil swissprot:YDJJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDJJ_ECOLI pepdigest swissprot:YDJJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDJJ_ECOLI pepinfo swissprot:YDJJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDJJ_ECOLI pepnet swissprot:YDJJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDJJ_ECOLI pepstats swissprot:YDJJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDJJ_ECOLI pepwheel swissprot:YDJJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDJJ_ECOLI pepwindow swissprot:YDJJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDJJ_ECOLI sigcleave swissprot:YDJJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDJJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4260372 11 # EcoGene EG12861 yecF # IntAct P0AD07 15 # InterPro IPR019705 DUF2594 # Organism YECF_ECOLI Escherichia coli (strain K12) # PATRIC 32119165 VBIEscCol129921_1997 # PIR H64954 H64954 # Pfam PF10769 DUF2594 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YECF_ECOLI Uncharacterized protein YecF # RefSeq NP_416425 NC_000913.3 # RefSeq WP_000106474 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=X03691; Type=Frameshift; Positions=38; Evidence={ECO 0000305}; # eggNOG ENOG4105XVG Bacteria # eggNOG ENOG41122AK LUCA BLAST swissprot:YECF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YECF_ECOLI BioCyc ECOL316407:JW1900-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1900-MONOMER BioCyc EcoCyc:EG12861-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12861-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/nar/14.5.2301 http://dx.doi.org/10.1093/nar/14.5.2301 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X03691 http://www.ebi.ac.uk/ena/data/view/X03691 EchoBASE EB2703 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2703 EcoGene EG12861 http://www.ecogene.org/geneInfo.php?eg_id=EG12861 EnsemblBacteria AAC74982 http://www.ensemblgenomes.org/id/AAC74982 EnsemblBacteria AAC74982 http://www.ensemblgenomes.org/id/AAC74982 EnsemblBacteria BAA15735 http://www.ensemblgenomes.org/id/BAA15735 EnsemblBacteria BAA15735 http://www.ensemblgenomes.org/id/BAA15735 EnsemblBacteria BAA15735 http://www.ensemblgenomes.org/id/BAA15735 EnsemblBacteria b1915 http://www.ensemblgenomes.org/id/b1915 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946420 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946420 HOGENOM HOG000219285 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219285&db=HOGENOM6 IntAct P0AD07 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AD07* InterPro IPR019705 http://www.ebi.ac.uk/interpro/entry/IPR019705 KEGG_Gene ecj:JW1900 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1900 KEGG_Gene eco:b1915 http://www.genome.jp/dbget-bin/www_bget?eco:b1915 OMA AHEVSCL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AHEVSCL PSORT swissprot:YECF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YECF_ECOLI PSORT-B swissprot:YECF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YECF_ECOLI PSORT2 swissprot:YECF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YECF_ECOLI Pfam PF10769 http://pfam.xfam.org/family/PF10769 Phobius swissprot:YECF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YECF_ECOLI ProteinModelPortal P0AD07 http://www.proteinmodelportal.org/query/uniprot/P0AD07 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3515318 http://www.ncbi.nlm.nih.gov/pubmed/3515318 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416425 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416425 RefSeq WP_000106474 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000106474 STRING 511145.b1915 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1915&targetmode=cogs UniProtKB YECF_ECOLI http://www.uniprot.org/uniprot/YECF_ECOLI UniProtKB-AC P0AD07 http://www.uniprot.org/uniprot/P0AD07 charge swissprot:YECF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YECF_ECOLI eggNOG ENOG4105XVG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105XVG eggNOG ENOG41122AK http://eggnogapi.embl.de/nog_data/html/tree/ENOG41122AK epestfind swissprot:YECF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YECF_ECOLI garnier swissprot:YECF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YECF_ECOLI helixturnhelix swissprot:YECF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YECF_ECOLI hmoment swissprot:YECF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YECF_ECOLI iep swissprot:YECF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YECF_ECOLI inforesidue swissprot:YECF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YECF_ECOLI octanol swissprot:YECF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YECF_ECOLI pepcoil swissprot:YECF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YECF_ECOLI pepdigest swissprot:YECF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YECF_ECOLI pepinfo swissprot:YECF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YECF_ECOLI pepnet swissprot:YECF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YECF_ECOLI pepstats swissprot:YECF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YECF_ECOLI pepwheel swissprot:YECF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YECF_ECOLI pepwindow swissprot:YECF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YECF_ECOLI sigcleave swissprot:YECF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YECF_ECOLI ## Database ID URL or Descriptions # BioGrid 4261791 140 # EcoGene EG13660 chiQ # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GOslim_component GO:0005886 plasma membrane # INDUCTION CHIQ_ECOLI In the absence of chitobiose, expression of chiPQ is silenced by the MicM small regulatory RNA (sRNA), which sequesters the ribosome binding site of the chiPQ mRNA by an antisense mechanism. In the presence of chitosugars, the chbBCARFG chitobiose operon is induced and acts as an RNA trap to degrade the constitutively expressed MicM, leading to the translation of chiPQ. {ECO 0000269|PubMed 19400782, ECO 0000269|PubMed 19682266}. # InterPro IPR025727 YbfN-like # Organism CHIQ_ECOLI Escherichia coli (strain K12) # PATRIC 32116557 VBIEscCol129921_0711 # PIR A64803 A64803 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF13982 YbfN # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CHIQ_ECOLI Uncharacterized lipoprotein ChiQ # RefSeq NP_415208 NC_000913.3 # RefSeq WP_000733579 NZ_LN832404.1 # SUBCELLULAR LOCATION CHIQ_ECOLI Cell membrane {ECO 0000305|PubMed 12876315}; Lipid-anchor {ECO 0000305|PubMed 12876315}. # eggNOG ENOG4105GX6 Bacteria # eggNOG ENOG4111N6E LUCA BLAST swissprot:CHIQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CHIQ_ECOLI BioCyc ECOL316407:JW0668-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0668-MONOMER BioCyc EcoCyc:G6371-MONOMER http://biocyc.org/getid?id=EcoCyc:G6371-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1110/ps.0303703 http://dx.doi.org/10.1110/ps.0303703 DOI 10.1111/j.1365-2958.2009.06688.x http://dx.doi.org/10.1111/j.1365-2958.2009.06688.x DOI 10.1111/j.1365-2958.2009.06807.x http://dx.doi.org/10.1111/j.1365-2958.2009.06807.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3424 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3424 EcoGene EG13660 http://www.ecogene.org/geneInfo.php?eg_id=EG13660 EnsemblBacteria AAC73776 http://www.ensemblgenomes.org/id/AAC73776 EnsemblBacteria AAC73776 http://www.ensemblgenomes.org/id/AAC73776 EnsemblBacteria BAA35330 http://www.ensemblgenomes.org/id/BAA35330 EnsemblBacteria BAA35330 http://www.ensemblgenomes.org/id/BAA35330 EnsemblBacteria BAA35330 http://www.ensemblgenomes.org/id/BAA35330 EnsemblBacteria b0682 http://www.ensemblgenomes.org/id/b0682 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 945713 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945713 HOGENOM HOG000117979 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117979&db=HOGENOM6 InterPro IPR025727 http://www.ebi.ac.uk/interpro/entry/IPR025727 KEGG_Gene ecj:JW0668 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0668 KEGG_Gene eco:b0682 http://www.genome.jp/dbget-bin/www_bget?eco:b0682 OMA HEQFATQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HEQFATQ PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:CHIQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CHIQ_ECOLI PSORT-B swissprot:CHIQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CHIQ_ECOLI PSORT2 swissprot:CHIQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CHIQ_ECOLI Pfam PF13982 http://pfam.xfam.org/family/PF13982 Phobius swissprot:CHIQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CHIQ_ECOLI ProteinModelPortal P75734 http://www.proteinmodelportal.org/query/uniprot/P75734 PubMed 12876315 http://www.ncbi.nlm.nih.gov/pubmed/12876315 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19400782 http://www.ncbi.nlm.nih.gov/pubmed/19400782 PubMed 19682266 http://www.ncbi.nlm.nih.gov/pubmed/19682266 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415208 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415208 RefSeq WP_000733579 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000733579 STRING 511145.b0682 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0682&targetmode=cogs UniProtKB CHIQ_ECOLI http://www.uniprot.org/uniprot/CHIQ_ECOLI UniProtKB-AC P75734 http://www.uniprot.org/uniprot/P75734 charge swissprot:CHIQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CHIQ_ECOLI eggNOG ENOG4105GX6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105GX6 eggNOG ENOG4111N6E http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111N6E epestfind swissprot:CHIQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CHIQ_ECOLI garnier swissprot:CHIQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CHIQ_ECOLI helixturnhelix swissprot:CHIQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CHIQ_ECOLI hmoment swissprot:CHIQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CHIQ_ECOLI iep swissprot:CHIQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CHIQ_ECOLI inforesidue swissprot:CHIQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CHIQ_ECOLI octanol swissprot:CHIQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CHIQ_ECOLI pepcoil swissprot:CHIQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CHIQ_ECOLI pepdigest swissprot:CHIQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CHIQ_ECOLI pepinfo swissprot:CHIQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CHIQ_ECOLI pepnet swissprot:CHIQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CHIQ_ECOLI pepstats swissprot:CHIQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CHIQ_ECOLI pepwheel swissprot:CHIQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CHIQ_ECOLI pepwindow swissprot:CHIQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CHIQ_ECOLI sigcleave swissprot:CHIQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CHIQ_ECOLI ## Database ID URL or Descriptions # EcoGene EG40004 insD4 # FUNCTION INSD4_ECOLI Involved in the transposition of the insertion sequence IS2. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006310 DNA recombination; IEA:UniProtKB-KW. # GO_process GO:0015074 DNA integration; IEA:InterPro. # GO_process GO:0032196 transposition; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 3.30.420.10 -; 1. # InterPro IPR001584 Integrase_cat-core # InterPro IPR012337 RNaseH-like_dom # InterPro IPR025948 HTH-like_dom # Organism INSD4_ECOLI Escherichia coli (strain K12) # PIR A64764 C65092 # PROSITE PS50994 INTEGRASE # Pfam PF00665 rve # Pfam PF13276 HTH_21 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSD4_ECOLI Transposase InsD for insertion element IS2H # RefSeq NP_061399 NC_002483.1 # RefSeq NP_414895 NC_000913.3 # RefSeq NP_415920 NC_000913.3 # RefSeq NP_416500 NC_000913.3 # RefSeq NP_417337 NC_000913.3 # RefSeq NP_417517 NC_000913.3 # RefSeq NP_418693 NC_000913.3 # RefSeq WP_000376502 NZ_LN832404.1 # RefSeq YP_424823 NC_007635.1 # SIMILARITY Contains 1 integrase catalytic domain. {ECO:0000255|PROSITE-ProRule PRU00457}. # SUPFAM SSF53098 SSF53098 # eggNOG ENOG4108MVM Bacteria # eggNOG ENOG410Z4Y8 LUCA BLAST swissprot:INSD4_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSD4_ECOLI DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 EchoBASE EB4737 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4737 EcoGene EG40004 http://www.ecogene.org/geneInfo.php?eg_id=EG40004 EnsemblBacteria AAC75899 http://www.ensemblgenomes.org/id/AAC75899 EnsemblBacteria AAC75899 http://www.ensemblgenomes.org/id/AAC75899 EnsemblBacteria BAE76927 http://www.ensemblgenomes.org/id/BAE76927 EnsemblBacteria BAE76927 http://www.ensemblgenomes.org/id/BAE76927 EnsemblBacteria BAE76927 http://www.ensemblgenomes.org/id/BAE76927 EnsemblBacteria b2860 http://www.ensemblgenomes.org/id/b2860 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0015074 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015074 GO_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 3.30.420.10 http://www.cathdb.info/version/latest/superfamily/3.30.420.10 GeneID 1263540 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263540 GeneID 3829341 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3829341 GeneID 945203 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945203 GeneID 945952 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945952 GeneID 946403 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946403 GeneID 947346 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947346 GeneID 947517 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947517 GeneID 948779 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948779 InParanoid P0CF56 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CF56 InterPro IPR001584 http://www.ebi.ac.uk/interpro/entry/IPR001584 InterPro IPR012337 http://www.ebi.ac.uk/interpro/entry/IPR012337 InterPro IPR025948 http://www.ebi.ac.uk/interpro/entry/IPR025948 KEGG_Gene ecj:JW2826 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2826 KEGG_Gene eco:b0361 http://www.genome.jp/dbget-bin/www_bget?eco:b0361 KEGG_Gene eco:b1402 http://www.genome.jp/dbget-bin/www_bget?eco:b1402 KEGG_Gene eco:b1996 http://www.genome.jp/dbget-bin/www_bget?eco:b1996 KEGG_Gene eco:b2860 http://www.genome.jp/dbget-bin/www_bget?eco:b2860 KEGG_Gene eco:b3045 http://www.genome.jp/dbget-bin/www_bget?eco:b3045 KEGG_Gene eco:b4273 http://www.genome.jp/dbget-bin/www_bget?eco:b4273 PROSITE PS50994 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50994 PSORT swissprot:INSD4_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSD4_ECOLI PSORT-B swissprot:INSD4_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSD4_ECOLI PSORT2 swissprot:INSD4_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSD4_ECOLI Pfam PF00665 http://pfam.xfam.org/family/PF00665 Pfam PF13276 http://pfam.xfam.org/family/PF13276 Phobius swissprot:INSD4_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSD4_ECOLI PhylomeDB P0CF56 http://phylomedb.org/?seqid=P0CF56 ProteinModelPortal P0CF56 http://www.proteinmodelportal.org/query/uniprot/P0CF56 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_061399 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061399 RefSeq NP_414895 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414895 RefSeq NP_415920 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415920 RefSeq NP_416500 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416500 RefSeq NP_417337 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417337 RefSeq NP_417517 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417517 RefSeq NP_418693 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418693 RefSeq WP_000376502 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000376502 RefSeq YP_424823 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_424823 SMR P0CF56 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0CF56 STRING 511145.b4273 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4273&targetmode=cogs SUPFAM SSF53098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098 UniProtKB INSD4_ECOLI http://www.uniprot.org/uniprot/INSD4_ECOLI UniProtKB-AC P0CF56 http://www.uniprot.org/uniprot/P0CF56 charge swissprot:INSD4_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSD4_ECOLI eggNOG ENOG4108MVM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MVM eggNOG ENOG410Z4Y8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Z4Y8 epestfind swissprot:INSD4_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSD4_ECOLI garnier swissprot:INSD4_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSD4_ECOLI helixturnhelix swissprot:INSD4_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSD4_ECOLI hmoment swissprot:INSD4_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSD4_ECOLI iep swissprot:INSD4_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSD4_ECOLI inforesidue swissprot:INSD4_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSD4_ECOLI octanol swissprot:INSD4_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSD4_ECOLI pepcoil swissprot:INSD4_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSD4_ECOLI pepdigest swissprot:INSD4_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSD4_ECOLI pepinfo swissprot:INSD4_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSD4_ECOLI pepnet swissprot:INSD4_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSD4_ECOLI pepstats swissprot:INSD4_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSD4_ECOLI pepwheel swissprot:INSD4_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSD4_ECOLI pepwindow swissprot:INSD4_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSD4_ECOLI sigcleave swissprot:INSD4_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSD4_ECOLI ## Database ID URL or Descriptions # BioGrid 4262327 17 # EcoGene EG13063 ygfM # GO_function GO:0016614 oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro. # GO_function GO:0050660 flavin adenine dinucleotide binding; IEA:InterPro. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # Gene3D 3.30.465.10 -; 1. # InterPro IPR002346 Mopterin_DH_FAD-bd # InterPro IPR005107 CO_DH_flav_C # InterPro IPR016166 FAD-bd_2 # InterPro IPR016169 CO_DH_flavot_FAD-bd_sub2 # InterPro IPR017698 Se_Rdtase_FAD-bd_su # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko00450 Selenocompound metabolism # Organism YGFM_ECOLI Escherichia coli (strain K12) # PATRIC 32121170 VBIEscCol129921_2973 # PIR H65071 H65071 # PROSITE PS51387 FAD_PCMH # Pfam PF00941 FAD_binding_5 # Pfam PF03450 CO_deh_flav_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGFM_ECOLI Uncharacterized protein YgfM # RefSeq NP_417356 NC_000913.3 # RefSeq WP_000572462 NZ_LN832404.1 # SIMILARITY Contains 1 FAD-binding PCMH-type domain. {ECO:0000255|PROSITE-ProRule PRU00718}. # SMART SM01092 CO_deh_flav_C # SUPFAM SSF55447 SSF55447 # SUPFAM SSF56176 SSF56176 # TIGRFAMs TIGR03312 Se_sel_red_FAD # eggNOG ENOG410873Y Bacteria # eggNOG ENOG410YU1D LUCA BLAST swissprot:YGFM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGFM_ECOLI BioCyc ECOL316407:JW2848-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2848-MONOMER BioCyc EcoCyc:G7499-MONOMER http://biocyc.org/getid?id=EcoCyc:G7499-MONOMER COG COG1319 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1319 DIP DIP-48265N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48265N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 EchoBASE EB2875 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2875 EcoGene EG13063 http://www.ecogene.org/geneInfo.php?eg_id=EG13063 EnsemblBacteria AAC75918 http://www.ensemblgenomes.org/id/AAC75918 EnsemblBacteria AAC75918 http://www.ensemblgenomes.org/id/AAC75918 EnsemblBacteria BAE76946 http://www.ensemblgenomes.org/id/BAE76946 EnsemblBacteria BAE76946 http://www.ensemblgenomes.org/id/BAE76946 EnsemblBacteria BAE76946 http://www.ensemblgenomes.org/id/BAE76946 EnsemblBacteria b2880 http://www.ensemblgenomes.org/id/b2880 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016614 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016614 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.30.465.10 http://www.cathdb.info/version/latest/superfamily/3.30.465.10 GeneID 949071 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949071 HOGENOM HOG000277448 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000277448&db=HOGENOM6 InterPro IPR002346 http://www.ebi.ac.uk/interpro/entry/IPR002346 InterPro IPR005107 http://www.ebi.ac.uk/interpro/entry/IPR005107 InterPro IPR016166 http://www.ebi.ac.uk/interpro/entry/IPR016166 InterPro IPR016169 http://www.ebi.ac.uk/interpro/entry/IPR016169 InterPro IPR017698 http://www.ebi.ac.uk/interpro/entry/IPR017698 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW2848 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2848 KEGG_Gene eco:b2880 http://www.genome.jp/dbget-bin/www_bget?eco:b2880 KEGG_Orthology KO:K12529 http://www.genome.jp/dbget-bin/www_bget?KO:K12529 KEGG_Pathway ko00450 http://www.genome.jp/kegg-bin/show_pathway?ko00450 OMA CATRRIS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CATRRIS PROSITE PS51387 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51387 PSORT swissprot:YGFM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGFM_ECOLI PSORT-B swissprot:YGFM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGFM_ECOLI PSORT2 swissprot:YGFM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGFM_ECOLI Pfam PF00941 http://pfam.xfam.org/family/PF00941 Pfam PF03450 http://pfam.xfam.org/family/PF03450 Phobius swissprot:YGFM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGFM_ECOLI ProteinModelPortal P64557 http://www.proteinmodelportal.org/query/uniprot/P64557 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417356 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417356 RefSeq WP_000572462 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000572462 SMART SM01092 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01092 SMR P64557 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P64557 STRING 511145.b2880 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2880&targetmode=cogs STRING COG1319 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1319&targetmode=cogs SUPFAM SSF55447 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55447 SUPFAM SSF56176 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56176 TIGRFAMs TIGR03312 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03312 UniProtKB YGFM_ECOLI http://www.uniprot.org/uniprot/YGFM_ECOLI UniProtKB-AC P64557 http://www.uniprot.org/uniprot/P64557 charge swissprot:YGFM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGFM_ECOLI eggNOG ENOG410873Y http://eggnogapi.embl.de/nog_data/html/tree/ENOG410873Y eggNOG ENOG410YU1D http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YU1D epestfind swissprot:YGFM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGFM_ECOLI garnier swissprot:YGFM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGFM_ECOLI helixturnhelix swissprot:YGFM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGFM_ECOLI hmoment swissprot:YGFM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGFM_ECOLI iep swissprot:YGFM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGFM_ECOLI inforesidue swissprot:YGFM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGFM_ECOLI octanol swissprot:YGFM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGFM_ECOLI pepcoil swissprot:YGFM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGFM_ECOLI pepdigest swissprot:YGFM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGFM_ECOLI pepinfo swissprot:YGFM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGFM_ECOLI pepnet swissprot:YGFM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGFM_ECOLI pepstats swissprot:YGFM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGFM_ECOLI pepwheel swissprot:YGFM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGFM_ECOLI pepwindow swissprot:YGFM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGFM_ECOLI sigcleave swissprot:YGFM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGFM_ECOLI ## Database ID URL or Descriptions # BioGrid 4259483 94 # DISRUPTION PHENOTYPE Mutants are resistant to proline-rich antimicrobial peptides of eukaryotic origin. {ECO:0000269|PubMed 17725560}. # EcoGene EG10928 sbmA # FUNCTION SBMA_ECOLI Uptake of antimicrobial peptides. Required for the transport of microcin B17 (MccB17), microcin 25 (Mcc25) and proline-rich antimicrobial peptides into the cell. {ECO 0000269|PubMed 17725560, ECO 0000269|PubMed 3543211, ECO 0000269|PubMed 7768835}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:InterPro. # GO_function GO:0015197 peptide transporter activity; IDA:EcoCyc. # GO_function GO:0015291 secondary active transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0015638 microcin uptake transporter activity; IMP:EcoCyc. # GO_function GO:0019534 toxin transporter activity; IDA:EcoCyc. # GO_function GO:0042626 ATPase activity, coupled to transmembrane movement of substances; IEA:InterPro. # GO_process GO:0015031 protein transport; IEA:UniProtKB-KW. # GO_process GO:0015833 peptide transport; IDA:EcoCyc. # GO_process GO:0042884 microcin transport; IMP:EcoCyc. # GO_process GO:0042885 microcin B17 transport; IMP:EcoCyc. # GO_process GO:0046677 response to antibiotic; IMP:EcoCyc. # GO_process GO:1901998 toxin transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # InterPro IPR009248 SbmA_BacA # InterPro IPR011527 ABC1_TM_dom # Organism SBMA_ECOLI Escherichia coli (strain K12) # PATRIC 32115895 VBIEscCol129921_0389 # PIR A64766 A64766 # Pfam PF05992 SbmA_BacA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SBMA_ECOLI Peptide antibiotic transporter SbmA # RefSeq NP_414911 NC_000913.3 # RefSeq WP_001301663 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18100.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the peptide uptake permease (PUP) (TC 9.A.18) family. {ECO 0000305}. # SUBCELLULAR LOCATION SBMA_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # SUPFAM SSF90123 SSF90123 # TCDB 9.A.18.1 the peptide uptake permease (pup) family # eggNOG COG1133 LUCA # eggNOG ENOG4108DQG Bacteria BLAST swissprot:SBMA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SBMA_ECOLI BioCyc ECOL316407:JW0368-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0368-MONOMER BioCyc EcoCyc:SBMA-MONOMER http://biocyc.org/getid?id=EcoCyc:SBMA-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1099/00221287-132-6-1685 http://dx.doi.org/10.1099/00221287-132-6-1685 DOI 10.1111/j.1365-2958.2007.05903.x http://dx.doi.org/10.1111/j.1365-2958.2007.05903.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EMBL X54153 http://www.ebi.ac.uk/ena/data/view/X54153 EchoBASE EB0921 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0921 EcoGene EG10928 http://www.ecogene.org/geneInfo.php?eg_id=EG10928 EnsemblBacteria AAC73480 http://www.ensemblgenomes.org/id/AAC73480 EnsemblBacteria AAC73480 http://www.ensemblgenomes.org/id/AAC73480 EnsemblBacteria BAE76158 http://www.ensemblgenomes.org/id/BAE76158 EnsemblBacteria BAE76158 http://www.ensemblgenomes.org/id/BAE76158 EnsemblBacteria BAE76158 http://www.ensemblgenomes.org/id/BAE76158 EnsemblBacteria b0377 http://www.ensemblgenomes.org/id/b0377 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0015197 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015197 GO_function GO:0015291 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015291 GO_function GO:0015638 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015638 GO_function GO:0019534 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019534 GO_function GO:0042626 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042626 GO_process GO:0015031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031 GO_process GO:0015833 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015833 GO_process GO:0042884 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042884 GO_process GO:0042885 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042885 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GO_process GO:1901998 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901998 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 946884 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946884 HOGENOM HOG000100637 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000100637&db=HOGENOM6 InParanoid P0AFY6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFY6 InterPro IPR009248 http://www.ebi.ac.uk/interpro/entry/IPR009248 InterPro IPR011527 http://www.ebi.ac.uk/interpro/entry/IPR011527 KEGG_Gene ecj:JW0368 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0368 KEGG_Gene eco:b0377 http://www.genome.jp/dbget-bin/www_bget?eco:b0377 OMA SFFPQPK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SFFPQPK PSORT swissprot:SBMA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SBMA_ECOLI PSORT-B swissprot:SBMA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SBMA_ECOLI PSORT2 swissprot:SBMA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SBMA_ECOLI Pfam PF05992 http://pfam.xfam.org/family/PF05992 Phobius swissprot:SBMA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SBMA_ECOLI PhylomeDB P0AFY6 http://phylomedb.org/?seqid=P0AFY6 ProteinModelPortal P0AFY6 http://www.proteinmodelportal.org/query/uniprot/P0AFY6 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17725560 http://www.ncbi.nlm.nih.gov/pubmed/17725560 PubMed 3543211 http://www.ncbi.nlm.nih.gov/pubmed/3543211 PubMed 7768835 http://www.ncbi.nlm.nih.gov/pubmed/7768835 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414911 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414911 RefSeq WP_001301663 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001301663 STRING 511145.b0377 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0377&targetmode=cogs SUPFAM SSF90123 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90123 TCDB 9.A.18.1 http://www.tcdb.org/search/result.php?tc=9.A.18.1 UniProtKB SBMA_ECOLI http://www.uniprot.org/uniprot/SBMA_ECOLI UniProtKB-AC P0AFY6 http://www.uniprot.org/uniprot/P0AFY6 charge swissprot:SBMA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SBMA_ECOLI eggNOG COG1133 http://eggnogapi.embl.de/nog_data/html/tree/COG1133 eggNOG ENOG4108DQG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108DQG epestfind swissprot:SBMA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SBMA_ECOLI garnier swissprot:SBMA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SBMA_ECOLI helixturnhelix swissprot:SBMA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SBMA_ECOLI hmoment swissprot:SBMA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SBMA_ECOLI iep swissprot:SBMA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SBMA_ECOLI inforesidue swissprot:SBMA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SBMA_ECOLI octanol swissprot:SBMA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SBMA_ECOLI pepcoil swissprot:SBMA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SBMA_ECOLI pepdigest swissprot:SBMA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SBMA_ECOLI pepinfo swissprot:SBMA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SBMA_ECOLI pepnet swissprot:SBMA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SBMA_ECOLI pepstats swissprot:SBMA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SBMA_ECOLI pepwheel swissprot:SBMA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SBMA_ECOLI pepwindow swissprot:SBMA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SBMA_ECOLI sigcleave swissprot:SBMA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SBMA_ECOLI ## Database ID URL or Descriptions # AltName EIIB'BC-Fru {ECO:0000305|PubMed 8626640} # AltName EIIB'BC-Fru {ECO:0000305|PubMed 8626640} # AltName EIII-Fru {ECO:0000303|PubMed 3076173} # AltName Fructose permease IIC component {ECO:0000303|PubMed 3076173} # AltName Fructose-specific phosphotransferase enzyme IIB component {ECO:0000303|PubMed 3076173} # AltName Fructose-specific phosphotransferase enzyme IIB component {ECO:0000303|PubMed 3076173} # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=5.4 uM for fructose {ECO 0000269|PubMed:8626640}; # BioGrid 4260463 14 # CATALYTIC ACTIVITY PTFBC_ECOLI [Protein]-N(pi)-phospho-L-histidine + D- fructose(Side 1) = [protein]-L-histidine + D-fructose 1- phosphate(Side 2). {ECO 0000269|PubMed 8626640, ECO 0000305|PubMed 3510127}. # CDD cd05569 PTS_IIB_fructose # DOMAIN PTFBC_ECOLI In the N-terminal, the PTS system fructose-specific possesses a duplicated EIIB domain (EIIB' domain) which lacks the active site and functions to facilitate phosphoryl transfer between the EIIA domain of diphosphoryl transfer protein (DTP) and the EIIB domain. Construction of a protein lacking the EIIB' domain shows that it is functional for fructose transport in vivo as well as fructose phosphorylation in vitro. The presence of the EIIB' domain, however, is required for normal high affinity recognition of DTP by the PTS system fructose-specific as well as for normal rates of phosphoryl transfer between the EIIA and EIIB domains of DTP and PTS system fructose-specific, respectively. {ECO 0000269|PubMed 8626640}. # DOMAIN PTFBC_ECOLI The EIIC type-2 domain forms the PTS system translocation channel and contains the specific substrate-binding site. {ECO 0000255|PROSITE-ProRule PRU00427}. # DOMAIN PTFBC_ECOLI The PTS EIIB type-2 domain is phosphorylated by phospho- EIIA on a cysteinyl residue. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the PTS EIIC type-2 domain. {ECO 0000255|PROSITE- ProRule PRU00422}. # EcoGene EG10336 fruA # FUNCTION PTFBC_ECOLI The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FruAB PTS system is involved in fructose transport. {ECO 0000269|PubMed 3510127, ECO 0000269|PubMed 8626640, ECO 0000305|PubMed 3076173}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0016301 kinase activity; IEA:UniProtKB-KW. # GO_function GO:0022877 protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity; IEA:InterPro. # GO_function GO:0090582 protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity; IMP:EcoCyc. # GO_function PTFBC_ECOLI GO 0005351 sugar proton symporter activity; IEA InterPro. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # INDUCTION By fructose. {ECO:0000250|UniProtKB P23355}. # IntAct P20966 2 # InterPro IPR003352 PTS_EIIC # InterPro IPR003353 PTS_IIB_fruc # InterPro IPR003501 PTS_EIIB_2/3 # InterPro IPR006327 PTS_IIC_fruc # InterPro IPR013011 PTS_EIIB_2 # InterPro IPR013014 PTS_EIIC_2 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00273 PTS system, fructose-specific II component # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko00051 Fructose and mannose metabolism # KEGG_Pathway ko02060 Phosphotransferase system (PTS) # Organism PTFBC_ECOLI Escherichia coli (strain K12) # PATRIC 32119683 VBIEscCol129921_2252 # PIR A34962 A34962 # PROSITE PS51099 PTS_EIIB_TYPE_2 # PROSITE PS51104 PTS_EIIC_TYPE_2 # Pfam PF02302 PTS_IIB # Pfam PF02378 PTS_EIIC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PTS system fructose-specific EIIB component {ECO:0000303|PubMed 3076173} # RecName PTS system fructose-specific EIIB'BC component {ECO:0000305|PubMed 8626640} # RecName PTS system fructose-specific EIIC component {ECO:0000303|PubMed 3076173} # RefSeq NP_416672 NC_000913.3 # RefSeq WP_000854447 NZ_LN832404.1 # SIMILARITY Contains 1 PTS EIIC type-2 domain. {ECO:0000255|PROSITE-ProRule PRU00427}. # SIMILARITY Contains 2 PTS EIIB type-2 domains. {ECO:0000255|PROSITE-ProRule PRU00422}. # SUBCELLULAR LOCATION PTFBC_ECOLI Cell inner membrane {ECO 0000255|PROSITE- ProRule PRU00427, ECO 0000269|PubMed 15919996, ECO 0000305|PubMed 3076173}; Multi-pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00427, ECO 0000269|PubMed 15919996, ECO 0000305|PubMed 3076173, ECO 0000305|PubMed 8626640}. # SUPFAM SSF52794 SSF52794; 2 # TCDB 4.A.2.1 the pts fructose-mannitol (fru) family # TIGRFAMs TIGR00829 FRU # TIGRFAMs TIGR01427 PTS_IIC_fructo # eggNOG COG1299 LUCA # eggNOG COG1445 LUCA # eggNOG COG3925 LUCA # eggNOG ENOG4105DM4 Bacteria BLAST swissprot:PTFBC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTFBC_ECOLI BioCyc ECOL316407:JW2154-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2154-MONOMER BioCyc EcoCyc:FRUA-MONOMER http://biocyc.org/getid?id=EcoCyc:FRUA-MONOMER BioCyc MetaCyc:FRUA-MONOMER http://biocyc.org/getid?id=MetaCyc:FRUA-MONOMER COG COG1299 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1299 DOI 10.1016/0014-5793(86)80042-4 http://dx.doi.org/10.1016/0014-5793(86)80042-4 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.271.17.9997 http://dx.doi.org/10.1074/jbc.271.17.9997 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1098/rspb.1990.0108 http://dx.doi.org/10.1098/rspb.1990.0108 DOI 10.1099/00221287-134-10-2757 http://dx.doi.org/10.1099/00221287-134-10-2757 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.202 {ECO:0000269|PubMed:8626640, ECO:0000305|PubMed:3510127} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.202 {ECO:0000269|PubMed:8626640, ECO:0000305|PubMed:3510127} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M23196 http://www.ebi.ac.uk/ena/data/view/M23196 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X53948 http://www.ebi.ac.uk/ena/data/view/X53948 ENZYME 2.7.1.202 {ECO:0000269|PubMed:8626640, ECO:0000305|PubMed:3510127} http://enzyme.expasy.org/EC/2.7.1.202 {ECO:0000269|PubMed:8626640, ECO:0000305|PubMed:3510127} EchoBASE EB0332 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0332 EcoGene EG10336 http://www.ecogene.org/geneInfo.php?eg_id=EG10336 EnsemblBacteria AAC75228 http://www.ensemblgenomes.org/id/AAC75228 EnsemblBacteria AAC75228 http://www.ensemblgenomes.org/id/AAC75228 EnsemblBacteria BAA15976 http://www.ensemblgenomes.org/id/BAA15976 EnsemblBacteria BAA15976 http://www.ensemblgenomes.org/id/BAA15976 EnsemblBacteria BAA15976 http://www.ensemblgenomes.org/id/BAA15976 EnsemblBacteria b2167 http://www.ensemblgenomes.org/id/b2167 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005351 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_function GO:0022877 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022877 GO_function GO:0090582 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090582 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 946672 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946672 HOGENOM HOG000227677 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000227677&db=HOGENOM6 InParanoid P20966 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P20966 IntAct P20966 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P20966* IntEnz 2.7.1.202 {ECO:0000269|PubMed:8626640, ECO:0000305|PubMed:3510127} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.202 {ECO:0000269|PubMed:8626640, ECO:0000305|PubMed:3510127} InterPro IPR003352 http://www.ebi.ac.uk/interpro/entry/IPR003352 InterPro IPR003353 http://www.ebi.ac.uk/interpro/entry/IPR003353 InterPro IPR003501 http://www.ebi.ac.uk/interpro/entry/IPR003501 InterPro IPR006327 http://www.ebi.ac.uk/interpro/entry/IPR006327 InterPro IPR013011 http://www.ebi.ac.uk/interpro/entry/IPR013011 InterPro IPR013014 http://www.ebi.ac.uk/interpro/entry/IPR013014 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2154 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2154 KEGG_Gene eco:b2167 http://www.genome.jp/dbget-bin/www_bget?eco:b2167 KEGG_Orthology KO:K02770 http://www.genome.jp/dbget-bin/www_bget?KO:K02770 KEGG_Pathway ko00051 http://www.genome.jp/kegg-bin/show_pathway?ko00051 KEGG_Pathway ko02060 http://www.genome.jp/kegg-bin/show_pathway?ko02060 KEGG_Reaction rn:R03232 http://www.genome.jp/dbget-bin/www_bget?rn:R03232 OMA HAVILAC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HAVILAC PROSITE PS51099 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51099 PROSITE PS51104 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51104 PSORT swissprot:PTFBC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTFBC_ECOLI PSORT-B swissprot:PTFBC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTFBC_ECOLI PSORT2 swissprot:PTFBC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTFBC_ECOLI Pfam PF02302 http://pfam.xfam.org/family/PF02302 Pfam PF02378 http://pfam.xfam.org/family/PF02378 Phobius swissprot:PTFBC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTFBC_ECOLI PhylomeDB P20966 http://phylomedb.org/?seqid=P20966 ProteinModelPortal P20966 http://www.proteinmodelportal.org/query/uniprot/P20966 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1981619 http://www.ncbi.nlm.nih.gov/pubmed/1981619 PubMed 3076173 http://www.ncbi.nlm.nih.gov/pubmed/3076173 PubMed 3510127 http://www.ncbi.nlm.nih.gov/pubmed/3510127 PubMed 8626640 http://www.ncbi.nlm.nih.gov/pubmed/8626640 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416672 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416672 RefSeq WP_000854447 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000854447 SMR P20966 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P20966 STRING 511145.b2167 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2167&targetmode=cogs STRING COG1299 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1299&targetmode=cogs SUPFAM SSF52794 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52794 TCDB 4.A.2.1 http://www.tcdb.org/search/result.php?tc=4.A.2.1 TIGRFAMs TIGR00829 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00829 TIGRFAMs TIGR01427 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01427 UniProtKB PTFBC_ECOLI http://www.uniprot.org/uniprot/PTFBC_ECOLI UniProtKB-AC P20966 http://www.uniprot.org/uniprot/P20966 charge swissprot:PTFBC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTFBC_ECOLI eggNOG COG1299 http://eggnogapi.embl.de/nog_data/html/tree/COG1299 eggNOG COG1445 http://eggnogapi.embl.de/nog_data/html/tree/COG1445 eggNOG COG3925 http://eggnogapi.embl.de/nog_data/html/tree/COG3925 eggNOG ENOG4105DM4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DM4 epestfind swissprot:PTFBC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTFBC_ECOLI garnier swissprot:PTFBC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTFBC_ECOLI helixturnhelix swissprot:PTFBC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTFBC_ECOLI hmoment swissprot:PTFBC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTFBC_ECOLI iep swissprot:PTFBC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTFBC_ECOLI inforesidue swissprot:PTFBC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTFBC_ECOLI octanol swissprot:PTFBC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTFBC_ECOLI pepcoil swissprot:PTFBC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTFBC_ECOLI pepdigest swissprot:PTFBC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTFBC_ECOLI pepinfo swissprot:PTFBC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTFBC_ECOLI pepnet swissprot:PTFBC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTFBC_ECOLI pepstats swissprot:PTFBC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTFBC_ECOLI pepwheel swissprot:PTFBC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTFBC_ECOLI pepwindow swissprot:PTFBC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTFBC_ECOLI sigcleave swissprot:PTFBC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTFBC_ECOLI ## Database ID URL or Descriptions # BioGrid 4261644 70 # COFACTOR YJJV_ECOLI Name=a divalent metal cation; Xref=ChEBI CHEBI 60240; Evidence={ECO 0000269|Ref.4}; Note=Binds 2 divalent metal cations per subunit. {ECO 0000269|Ref.4}; # EcoGene EG12598 yjjV # GO_function GO:0004536 deoxyribonuclease activity; IBA:GO_Central. # GO_function GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006308 DNA catabolic process; IBA:GO_Central. # GOslim_function GO:0004518 nuclease activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # IntAct P39408 4 # InterPro IPR001130 TatD_family # InterPro IPR018228 DNase_TatD-rel_CS # InterPro IPR032466 Metal_Hydrolase # KEGG_Brite ko01000 Enzymes # Organism YJJV_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10060 PTHR10060 # PATRIC 32124368 VBIEscCol129921_4524 # PDB 1ZZM X-ray; 1.80 A; A=1-259 # PIR S56602 S56602 # PIRSF PIRSF005902 DNase_TatD # PROSITE PS01090 TATD_2 # PROSITE PS01091 TATD_3 # PROSITE PS01137 TATD_1 # Pfam PF01026 TatD_DNase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Uncharacterized metal-dependent hydrolase YjjV {ECO 0000305} # RefSeq WP_000563040 NZ_LN832404.1 # RefSeq YP_026291 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA97274.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the TatD-type hydrolase family. {ECO 0000305}. # SUPFAM SSF51556 SSF51556 # eggNOG COG0084 LUCA # eggNOG ENOG4105EYA Bacteria BLAST swissprot:YJJV_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJJV_ECOLI BioCyc ECOL316407:JW4341-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4341-MONOMER BioCyc EcoCyc:G7952-MONOMER http://biocyc.org/getid?id=EcoCyc:G7952-MONOMER COG COG0084 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0084 DIP DIP-12661N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12661N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.-.- {ECO:0000305} http://www.genome.jp/dbget-bin/www_bget?EC:3.1.-.- {ECO:0000305} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 3.1.-.- {ECO:0000305} http://enzyme.expasy.org/EC/3.1.-.- {ECO:0000305} EchoBASE EB2483 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2483 EcoGene EG12598 http://www.ecogene.org/geneInfo.php?eg_id=EG12598 EnsemblBacteria AAC77331 http://www.ensemblgenomes.org/id/AAC77331 EnsemblBacteria AAC77331 http://www.ensemblgenomes.org/id/AAC77331 EnsemblBacteria BAE78367 http://www.ensemblgenomes.org/id/BAE78367 EnsemblBacteria BAE78367 http://www.ensemblgenomes.org/id/BAE78367 EnsemblBacteria BAE78367 http://www.ensemblgenomes.org/id/BAE78367 EnsemblBacteria b4378 http://www.ensemblgenomes.org/id/b4378 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004536 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004536 GO_function GO:0016888 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016888 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006308 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006308 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 GeneID 2847741 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2847741 HOGENOM HOG000201521 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000201521&db=HOGENOM6 InParanoid P39408 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39408 IntAct P39408 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39408* IntEnz 3.1.-.- {ECO:0000305} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.-.- {ECO:0000305} InterPro IPR001130 http://www.ebi.ac.uk/interpro/entry/IPR001130 InterPro IPR018228 http://www.ebi.ac.uk/interpro/entry/IPR018228 InterPro IPR032466 http://www.ebi.ac.uk/interpro/entry/IPR032466 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4341 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4341 KEGG_Gene eco:b4378 http://www.genome.jp/dbget-bin/www_bget?eco:b4378 KEGG_Orthology KO:K03424 http://www.genome.jp/dbget-bin/www_bget?KO:K03424 MINT MINT-1227009 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1227009 OMA GVIHGFS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GVIHGFS PANTHER PTHR10060 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10060 PDB 1ZZM http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZZM PDBsum 1ZZM http://www.ebi.ac.uk/pdbsum/1ZZM PROSITE PS01090 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01090 PROSITE PS01091 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01091 PROSITE PS01137 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01137 PSORT swissprot:YJJV_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJJV_ECOLI PSORT-B swissprot:YJJV_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJJV_ECOLI PSORT2 swissprot:YJJV_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJJV_ECOLI Pfam PF01026 http://pfam.xfam.org/family/PF01026 Phobius swissprot:YJJV_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJJV_ECOLI PhylomeDB P39408 http://phylomedb.org/?seqid=P39408 ProteinModelPortal P39408 http://www.proteinmodelportal.org/query/uniprot/P39408 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000563040 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000563040 RefSeq YP_026291 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026291 SMR P39408 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39408 STRING 511145.b4378 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4378&targetmode=cogs STRING COG0084 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0084&targetmode=cogs SUPFAM SSF51556 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51556 UniProtKB YJJV_ECOLI http://www.uniprot.org/uniprot/YJJV_ECOLI UniProtKB-AC P39408 http://www.uniprot.org/uniprot/P39408 charge swissprot:YJJV_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJJV_ECOLI eggNOG COG0084 http://eggnogapi.embl.de/nog_data/html/tree/COG0084 eggNOG ENOG4105EYA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EYA epestfind swissprot:YJJV_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJJV_ECOLI garnier swissprot:YJJV_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJJV_ECOLI helixturnhelix swissprot:YJJV_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJJV_ECOLI hmoment swissprot:YJJV_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJJV_ECOLI iep swissprot:YJJV_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJJV_ECOLI inforesidue swissprot:YJJV_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJJV_ECOLI octanol swissprot:YJJV_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJJV_ECOLI pepcoil swissprot:YJJV_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJJV_ECOLI pepdigest swissprot:YJJV_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJJV_ECOLI pepinfo swissprot:YJJV_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJJV_ECOLI pepnet swissprot:YJJV_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJJV_ECOLI pepstats swissprot:YJJV_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJJV_ECOLI pepwheel swissprot:YJJV_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJJV_ECOLI pepwindow swissprot:YJJV_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJJV_ECOLI sigcleave swissprot:YJJV_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJJV_ECOLI ## Database ID URL or Descriptions # AltName ODO2_ECOLI 2-oxoglutarate dehydrogenase complex component E2 # AltName ODO2_ECOLI Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex # BRENDA 2.3.1.61 2026 # BioGrid 4259945 11 # CATALYTIC ACTIVITY ODO2_ECOLI Succinyl-CoA + enzyme N(6)- (dihydrolipoyl)lysine = CoA + enzyme N(6)-(S- succinyldihydrolipoyl)lysine. # COFACTOR Name=(R)-lipoate; Xref=ChEBI:CHEBI 83088; Note=Binds 1 lipoyl cofactor covalently.; # EcoGene EG10980 sucB # FUNCTION ODO2_ECOLI The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3). # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0045252 oxoglutarate dehydrogenase complex; IDA:EcoliWiki. # GO_function GO:0004149 dihydrolipoyllysine-residue succinyltransferase activity; IDA:EcoliWiki. # GO_function GO:0031405 lipoic acid binding; IDA:EcoliWiki. # GO_process GO:0006099 tricarboxylic acid cycle; IMP:EcoliWiki. # GO_process GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_component GO:0043234 protein complex # GOslim_function GO:0008289 lipid binding # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.30.559.10 -; 1. # Gene3D 4.10.320.10 -; 1. # INTERACTION ODO2_ECOLI P0AFG3 sucA; NbExp=5; IntAct=EBI-558621, EBI-543523; # IntAct P0AFG6 39 # InterPro IPR000089 Biotin_lipoyl # InterPro IPR001078 2-oxoacid_DH_actylTfrase # InterPro IPR003016 2-oxoA_DH_lipoyl-BS # InterPro IPR004167 E3-bd # InterPro IPR006255 SucB # InterPro IPR011053 Single_hybrid_motif # InterPro IPR023213 CAT-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00020 Citrate cycle (TCA cycle) # KEGG_Pathway ko00310 Lysine degradation # Organism ODO2_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine step 6/6. # PATRIC 32116649 VBIEscCol129921_0757 # PDB 1BAL NMR; -; A=104-153 # PDB 1BBL NMR; -; A=104-153 # PDB 1C4T X-ray; 3.00 A; A/B/C=173-405 # PDB 1E2O X-ray; 3.00 A; A=173-405 # PDB 1PMR NMR; -; A=2-81 # PDB 1SCZ X-ray; 2.20 A; A=173-405 # PDB 1W4H NMR; -; A=109-153 # PDB 2BTG NMR; -; A=109-153 # PDB 2BTH NMR; -; A=109-153 # PDB 2WXC NMR; -; A=109-153 # PIR F64808 XUECSD # PROSITE PS00189 LIPOYL # PROSITE PS50968 BIOTINYL_LIPOYL # Pfam PF00198 2-oxoacid_dh # Pfam PF00364 Biotin_lipoyl # Pfam PF02817 E3_binding # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ODO2_ECOLI Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex # RefSeq NP_415255 NC_000913.3 # RefSeq WP_000099823 NZ_LN832404.1 # SIMILARITY Belongs to the 2-oxoacid dehydrogenase family. {ECO 0000305}. # SIMILARITY Contains 1 lipoyl-binding domain. {ECO:0000255|PROSITE-ProRule PRU01066, ECO:0000305}. # SUBUNIT ODO2_ECOLI Forms a 24-polypeptide structural core with octahedral symmetry. # SUPFAM SSF47005 SSF47005 # SUPFAM SSF51230 SSF51230 # TIGRFAMs TIGR01347 sucB # UniPathway UPA00868 UER00840 # eggNOG COG0508 LUCA # eggNOG ENOG4105C7S Bacteria BLAST swissprot:ODO2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ODO2_ECOLI BioCyc ECOL316407:JW0716-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0716-MONOMER BioCyc EcoCyc:E2O-MONOMER http://biocyc.org/getid?id=EcoCyc:E2O-MONOMER BioCyc MetaCyc:E2O-MONOMER http://biocyc.org/getid?id=MetaCyc:E2O-MONOMER COG COG0508 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0508 DIP DIP-35787N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35787N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1996.0632 http://dx.doi.org/10.1006/jmbi.1996.0632 DOI 10.1006/jmbi.1998.1924 http://dx.doi.org/10.1006/jmbi.1998.1924 DOI 10.1021/bi00128a021 http://dx.doi.org/10.1021/bi00128a021 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1110/ps.9.1.37 http://dx.doi.org/10.1110/ps.9.1.37 DOI 10.1111/j.1432-1033.1984.tb08199.x http://dx.doi.org/10.1111/j.1432-1033.1984.tb08199.x DOI 10.1111/j.1432-1033.1984.tb08200.x http://dx.doi.org/10.1111/j.1432-1033.1984.tb08200.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1266/ggs.82.291 http://dx.doi.org/10.1266/ggs.82.291 EC_number EC:2.3.1.61 http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.61 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01619 http://www.ebi.ac.uk/ena/data/view/J01619 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X00661 http://www.ebi.ac.uk/ena/data/view/X00661 EMBL X00664 http://www.ebi.ac.uk/ena/data/view/X00664 ENZYME 2.3.1.61 http://enzyme.expasy.org/EC/2.3.1.61 EchoBASE EB0973 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0973 EcoGene EG10980 http://www.ecogene.org/geneInfo.php?eg_id=EG10980 EnsemblBacteria AAC73821 http://www.ensemblgenomes.org/id/AAC73821 EnsemblBacteria AAC73821 http://www.ensemblgenomes.org/id/AAC73821 EnsemblBacteria BAA35393 http://www.ensemblgenomes.org/id/BAA35393 EnsemblBacteria BAA35393 http://www.ensemblgenomes.org/id/BAA35393 EnsemblBacteria BAA35393 http://www.ensemblgenomes.org/id/BAA35393 EnsemblBacteria b0727 http://www.ensemblgenomes.org/id/b0727 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0045252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045252 GO_function GO:0004149 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004149 GO_function GO:0031405 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031405 GO_process GO:0006099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006099 GO_process GO:0033512 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033512 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0008289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.30.559.10 http://www.cathdb.info/version/latest/superfamily/3.30.559.10 Gene3D 4.10.320.10 http://www.cathdb.info/version/latest/superfamily/4.10.320.10 GeneID 945307 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945307 HOGENOM HOG000281563 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000281563&db=HOGENOM6 InParanoid P0AFG6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFG6 IntAct P0AFG6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFG6* IntEnz 2.3.1.61 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.61 InterPro IPR000089 http://www.ebi.ac.uk/interpro/entry/IPR000089 InterPro IPR001078 http://www.ebi.ac.uk/interpro/entry/IPR001078 InterPro IPR003016 http://www.ebi.ac.uk/interpro/entry/IPR003016 InterPro IPR004167 http://www.ebi.ac.uk/interpro/entry/IPR004167 InterPro IPR006255 http://www.ebi.ac.uk/interpro/entry/IPR006255 InterPro IPR011053 http://www.ebi.ac.uk/interpro/entry/IPR011053 InterPro IPR023213 http://www.ebi.ac.uk/interpro/entry/IPR023213 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0716 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0716 KEGG_Gene eco:b0727 http://www.genome.jp/dbget-bin/www_bget?eco:b0727 KEGG_Orthology KO:K00658 http://www.genome.jp/dbget-bin/www_bget?KO:K00658 KEGG_Pathway ko00020 http://www.genome.jp/kegg-bin/show_pathway?ko00020 KEGG_Pathway ko00310 http://www.genome.jp/kegg-bin/show_pathway?ko00310 KEGG_Reaction rn:R02570 http://www.genome.jp/dbget-bin/www_bget?rn:R02570 KEGG_Reaction rn:R02571 http://www.genome.jp/dbget-bin/www_bget?rn:R02571 MINT MINT-1242608 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1242608 OMA TFGKKAR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TFGKKAR PDB 1BAL http://www.ebi.ac.uk/pdbe-srv/view/entry/1BAL PDB 1BBL http://www.ebi.ac.uk/pdbe-srv/view/entry/1BBL PDB 1C4T http://www.ebi.ac.uk/pdbe-srv/view/entry/1C4T PDB 1E2O http://www.ebi.ac.uk/pdbe-srv/view/entry/1E2O PDB 1PMR http://www.ebi.ac.uk/pdbe-srv/view/entry/1PMR PDB 1SCZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1SCZ PDB 1W4H http://www.ebi.ac.uk/pdbe-srv/view/entry/1W4H PDB 2BTG http://www.ebi.ac.uk/pdbe-srv/view/entry/2BTG PDB 2BTH http://www.ebi.ac.uk/pdbe-srv/view/entry/2BTH PDB 2WXC http://www.ebi.ac.uk/pdbe-srv/view/entry/2WXC PDBsum 1BAL http://www.ebi.ac.uk/pdbsum/1BAL PDBsum 1BBL http://www.ebi.ac.uk/pdbsum/1BBL PDBsum 1C4T http://www.ebi.ac.uk/pdbsum/1C4T PDBsum 1E2O http://www.ebi.ac.uk/pdbsum/1E2O PDBsum 1PMR http://www.ebi.ac.uk/pdbsum/1PMR PDBsum 1SCZ http://www.ebi.ac.uk/pdbsum/1SCZ PDBsum 1W4H http://www.ebi.ac.uk/pdbsum/1W4H PDBsum 2BTG http://www.ebi.ac.uk/pdbsum/2BTG PDBsum 2BTH http://www.ebi.ac.uk/pdbsum/2BTH PDBsum 2WXC http://www.ebi.ac.uk/pdbsum/2WXC PROSITE PS00189 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00189 PROSITE PS50968 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50968 PSORT swissprot:ODO2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ODO2_ECOLI PSORT-B swissprot:ODO2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ODO2_ECOLI PSORT2 swissprot:ODO2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ODO2_ECOLI Pfam PF00198 http://pfam.xfam.org/family/PF00198 Pfam PF00364 http://pfam.xfam.org/family/PF00364 Pfam PF02817 http://pfam.xfam.org/family/PF02817 Phobius swissprot:ODO2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ODO2_ECOLI PhylomeDB P0AFG6 http://phylomedb.org/?seqid=P0AFG6 ProteinModelPortal P0AFG6 http://www.proteinmodelportal.org/query/uniprot/P0AFG6 PubMed 10739245 http://www.ncbi.nlm.nih.gov/pubmed/10739245 PubMed 1554728 http://www.ncbi.nlm.nih.gov/pubmed/1554728 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17895580 http://www.ncbi.nlm.nih.gov/pubmed/17895580 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 6376123 http://www.ncbi.nlm.nih.gov/pubmed/6376123 PubMed 6376124 http://www.ncbi.nlm.nih.gov/pubmed/6376124 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 8950276 http://www.ncbi.nlm.nih.gov/pubmed/8950276 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9677295 http://www.ncbi.nlm.nih.gov/pubmed/9677295 RefSeq NP_415255 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415255 RefSeq WP_000099823 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000099823 SMR P0AFG6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFG6 STRING 511145.b0727 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0727&targetmode=cogs STRING COG0508 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0508&targetmode=cogs SUPFAM SSF47005 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47005 SUPFAM SSF51230 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51230 SWISS-2DPAGE P0AFG6 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AFG6 TIGRFAMs TIGR01347 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01347 UniProtKB ODO2_ECOLI http://www.uniprot.org/uniprot/ODO2_ECOLI UniProtKB-AC P0AFG6 http://www.uniprot.org/uniprot/P0AFG6 charge swissprot:ODO2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ODO2_ECOLI eggNOG COG0508 http://eggnogapi.embl.de/nog_data/html/tree/COG0508 eggNOG ENOG4105C7S http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C7S epestfind swissprot:ODO2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ODO2_ECOLI garnier swissprot:ODO2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ODO2_ECOLI helixturnhelix swissprot:ODO2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ODO2_ECOLI hmoment swissprot:ODO2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ODO2_ECOLI iep swissprot:ODO2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ODO2_ECOLI inforesidue swissprot:ODO2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ODO2_ECOLI octanol swissprot:ODO2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ODO2_ECOLI pepcoil swissprot:ODO2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ODO2_ECOLI pepdigest swissprot:ODO2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ODO2_ECOLI pepinfo swissprot:ODO2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ODO2_ECOLI pepnet swissprot:ODO2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ODO2_ECOLI pepstats swissprot:ODO2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ODO2_ECOLI pepwheel swissprot:ODO2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ODO2_ECOLI pepwindow swissprot:ODO2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ODO2_ECOLI sigcleave swissprot:ODO2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ODO2_ECOLI ## Database ID URL or Descriptions # AltName Triose-phosphate isomerase {ECO:0000255|HAMAP-Rule MF_00147} # BIOPHYSICOCHEMICAL PROPERTIES TPIS_ECOLI Kinetic parameters KM=1030 uM for D-glyceraldehyde 3-phosphate (at 25 degrees Celsius) {ECO 0000269|PubMed 9442062}; Note=Kcat is 54000 min(-1) for isomerase activity with D- glyceraldehyde 3-phosphate as substrate (at 25 degrees Celsius). {ECO 0000269|PubMed 9442062}; # BRENDA 5.3.1 2026 # CATALYTIC ACTIVITY TPIS_ECOLI D-glyceraldehyde 3-phosphate = glycerone phosphate. {ECO 0000255|HAMAP-Rule MF_00147, ECO 0000269|PubMed 9442062}. # CDD cd00311 TIM # DISRUPTION PHENOTYPE Cells lacking this gene accumulates methylglyoxal and are unable to grow on glucose, lactate or other carbon sources. {ECO:0000269|PubMed 24745552}. # EcoGene EG11015 tpiA # FUNCTION TPIS_ECOLI Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P). {ECO 0000255|HAMAP- Rule MF_00147, ECO 0000269|PubMed 9442062}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0004807 triose-phosphate isomerase activity; IDA:EcoCyc. # GO_process GO:0006094 gluconeogenesis; IMP:EcoliWiki. # GO_process GO:0006096 glycolytic process; IMP:EcoCyc. # GO_process GO:0006098 pentose-phosphate shunt; IEA:UniProtKB-HAMAP. # GO_process GO:0019563 glycerol catabolic process; IBA:GO_Central. # GO_process GO:0046166 glyceraldehyde-3-phosphate biosynthetic process; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.20.20.70 -; 1. # HAMAP MF_00147_B TIM_B # INDUCTION TPIS_ECOLI Induced by CsrA and repressed by spermidine. {ECO 0000269|PubMed 16223443, ECO 0000269|PubMed 7493933}. # INTERACTION TPIS_ECOLI Self; NbExp=3; IntAct=EBI-368978, EBI-368978; P29745 pepT; NbExp=4; IntAct=EBI-368978, EBI-555639; P09373 pflB; NbExp=5; IntAct=EBI-368978, EBI-546682; # IntAct P0A858 28 # InterPro IPR000652 Triosephosphate_isomerase # InterPro IPR013785 Aldolase_TIM # InterPro IPR020861 Triosephosphate_isomerase_AS # InterPro IPR022896 TrioseP_Isoase_bac/euk # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00010 Glycolysis / Gluconeogenesis # KEGG_Pathway ko00051 Fructose and mannose metabolism # KEGG_Pathway ko00562 Inositol phosphate metabolism # KEGG_Pathway ko00710 Carbon fixation in photosynthetic organisms # Organism TPIS_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21139 PTHR21139 # PATHWAY Carbohydrate biosynthesis; gluconeogenesis. {ECO:0000255|HAMAP-Rule MF_00147}. # PATHWAY Carbohydrate degradation; glycolysis; D-glyceraldehyde 3- phosphate from glycerone phosphate: step 1/1. {ECO 0000255|HAMAP- Rule:MF_00147}. # PATRIC 32123351 VBIEscCol129921_4036 # PDB 1TMH X-ray; 2.80 A; A/B/C/D=1-255 # PDB 1TRE X-ray; 2.60 A; A/B=1-255 # PIR B65198 ISECT # PROSITE PS00171 TIM_1 # PROSITE PS51440 TIM_2 # Pfam PF00121 TIM # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TPIS_ECOLI Triosephosphate isomerase {ECO 0000255|HAMAP-Rule MF_00147, ECO 0000303|PubMed 6092857} # RefSeq NP_418354 NC_000913.3 # RefSeq WP_001216325 NZ_LN832404.1 # SIMILARITY Belongs to the triosephosphate isomerase family. {ECO:0000255|HAMAP-Rule MF_00147}. # SUBCELLULAR LOCATION TPIS_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00147, ECO 0000305}. # SUBUNIT TPIS_ECOLI Homodimer. {ECO 0000255|HAMAP-Rule MF_00147, ECO 0000269|PubMed 15299515, ECO 0000269|PubMed 7809033, ECO 0000269|PubMed 8309937}. # SUPFAM SSF51351 SSF51351 # TIGRFAMs TIGR00419 tim # UniPathway UPA00109 UER00189 # eggNOG COG0149 LUCA # eggNOG ENOG4105CP7 Bacteria BLAST swissprot:TPIS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TPIS_ECOLI BioCyc ECOL316407:JW3890-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3890-MONOMER BioCyc EcoCyc:TPI-MONOMER http://biocyc.org/getid?id=EcoCyc:TPI-MONOMER BioCyc MetaCyc:TPI-MONOMER http://biocyc.org/getid?id=MetaCyc:TPI-MONOMER COG COG0149 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0149 DIP DIP-31849N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31849N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1998.1726 http://dx.doi.org/10.1006/jmbi.1998.1726 DOI 10.1007/BF00332765 http://dx.doi.org/10.1007/BF00332765 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.270.49.29096 http://dx.doi.org/10.1074/jbc.270.49.29096 DOI 10.1074/jbc.273.4.2199 http://dx.doi.org/10.1074/jbc.273.4.2199 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1093/protein/6.8.893 http://dx.doi.org/10.1093/protein/6.8.893 DOI 10.1093/protein/7.8.945 http://dx.doi.org/10.1093/protein/7.8.945 DOI 10.1107/S0907444993002628 http://dx.doi.org/10.1107/S0907444993002628 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1186/1471-2180-5-59 http://dx.doi.org/10.1186/1471-2180-5-59 DOI 10.1186/1475-2859-13-58 http://dx.doi.org/10.1186/1475-2859-13-58 DOI 10.1266/ggs.82.291 http://dx.doi.org/10.1266/ggs.82.291 EC_number EC:5.3.1.1 {ECO:0000255|HAMAP-Rule:MF_00147, ECO:0000269|PubMed:9442062} http://www.genome.jp/dbget-bin/www_bget?EC:5.3.1.1 {ECO:0000255|HAMAP-Rule:MF_00147, ECO:0000269|PubMed:9442062} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X00617 http://www.ebi.ac.uk/ena/data/view/X00617 ENZYME 5.3.1.1 {ECO:0000255|HAMAP-Rule:MF_00147, ECO:0000269|PubMed:9442062} http://enzyme.expasy.org/EC/5.3.1.1 {ECO:0000255|HAMAP-Rule:MF_00147, ECO:0000269|PubMed:9442062} EchoBASE EB1008 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1008 EcoGene EG11015 http://www.ecogene.org/geneInfo.php?eg_id=EG11015 EnsemblBacteria AAC76901 http://www.ensemblgenomes.org/id/AAC76901 EnsemblBacteria AAC76901 http://www.ensemblgenomes.org/id/AAC76901 EnsemblBacteria BAE77391 http://www.ensemblgenomes.org/id/BAE77391 EnsemblBacteria BAE77391 http://www.ensemblgenomes.org/id/BAE77391 EnsemblBacteria BAE77391 http://www.ensemblgenomes.org/id/BAE77391 EnsemblBacteria b3919 http://www.ensemblgenomes.org/id/b3919 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0004807 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004807 GO_process GO:0006094 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006094 GO_process GO:0006096 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006096 GO_process GO:0006098 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006098 GO_process GO:0019563 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019563 GO_process GO:0046166 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046166 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 948409 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948409 HAMAP MF_00147_B http://hamap.expasy.org/unirule/MF_00147_B HOGENOM HOG000226413 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000226413&db=HOGENOM6 InParanoid P0A858 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A858 IntAct P0A858 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A858* IntEnz 5.3.1.1 {ECO:0000255|HAMAP-Rule:MF_00147, ECO:0000269|PubMed:9442062} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.3.1.1 {ECO:0000255|HAMAP-Rule:MF_00147, ECO:0000269|PubMed:9442062} InterPro IPR000652 http://www.ebi.ac.uk/interpro/entry/IPR000652 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR020861 http://www.ebi.ac.uk/interpro/entry/IPR020861 InterPro IPR022896 http://www.ebi.ac.uk/interpro/entry/IPR022896 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3890 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3890 KEGG_Gene eco:b3919 http://www.genome.jp/dbget-bin/www_bget?eco:b3919 KEGG_Orthology KO:K01803 http://www.genome.jp/dbget-bin/www_bget?KO:K01803 KEGG_Pathway ko00010 http://www.genome.jp/kegg-bin/show_pathway?ko00010 KEGG_Pathway ko00051 http://www.genome.jp/kegg-bin/show_pathway?ko00051 KEGG_Pathway ko00562 http://www.genome.jp/kegg-bin/show_pathway?ko00562 KEGG_Pathway ko00710 http://www.genome.jp/kegg-bin/show_pathway?ko00710 KEGG_Reaction rn:R01015 http://www.genome.jp/dbget-bin/www_bget?rn:R01015 MINT MINT-1228759 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1228759 OMA WKMNNDL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WKMNNDL PANTHER PTHR21139 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21139 PDB 1TMH http://www.ebi.ac.uk/pdbe-srv/view/entry/1TMH PDB 1TRE http://www.ebi.ac.uk/pdbe-srv/view/entry/1TRE PDBsum 1TMH http://www.ebi.ac.uk/pdbsum/1TMH PDBsum 1TRE http://www.ebi.ac.uk/pdbsum/1TRE PROSITE PS00171 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00171 PROSITE PS51440 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51440 PSORT swissprot:TPIS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TPIS_ECOLI PSORT-B swissprot:TPIS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TPIS_ECOLI PSORT2 swissprot:TPIS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TPIS_ECOLI Pfam PF00121 http://pfam.xfam.org/family/PF00121 Phobius swissprot:TPIS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TPIS_ECOLI PhylomeDB P0A858 http://phylomedb.org/?seqid=P0A858 ProteinModelPortal P0A858 http://www.proteinmodelportal.org/query/uniprot/P0A858 PubMed 15299515 http://www.ncbi.nlm.nih.gov/pubmed/15299515 PubMed 16223443 http://www.ncbi.nlm.nih.gov/pubmed/16223443 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17895580 http://www.ncbi.nlm.nih.gov/pubmed/17895580 PubMed 24745552 http://www.ncbi.nlm.nih.gov/pubmed/24745552 PubMed 6092857 http://www.ncbi.nlm.nih.gov/pubmed/6092857 PubMed 7493933 http://www.ncbi.nlm.nih.gov/pubmed/7493933 PubMed 7809033 http://www.ncbi.nlm.nih.gov/pubmed/7809033 PubMed 8309937 http://www.ncbi.nlm.nih.gov/pubmed/8309937 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9442062 http://www.ncbi.nlm.nih.gov/pubmed/9442062 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 RefSeq NP_418354 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418354 RefSeq WP_001216325 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001216325 SMR P0A858 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A858 STRING 511145.b3919 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3919&targetmode=cogs STRING COG0149 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0149&targetmode=cogs SUPFAM SSF51351 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51351 SWISS-2DPAGE P0A858 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A858 TIGRFAMs TIGR00419 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00419 UniProtKB TPIS_ECOLI http://www.uniprot.org/uniprot/TPIS_ECOLI UniProtKB-AC P0A858 http://www.uniprot.org/uniprot/P0A858 charge swissprot:TPIS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TPIS_ECOLI eggNOG COG0149 http://eggnogapi.embl.de/nog_data/html/tree/COG0149 eggNOG ENOG4105CP7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CP7 epestfind swissprot:TPIS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TPIS_ECOLI garnier swissprot:TPIS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TPIS_ECOLI helixturnhelix swissprot:TPIS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TPIS_ECOLI hmoment swissprot:TPIS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TPIS_ECOLI iep swissprot:TPIS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TPIS_ECOLI inforesidue swissprot:TPIS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TPIS_ECOLI octanol swissprot:TPIS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TPIS_ECOLI pepcoil swissprot:TPIS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TPIS_ECOLI pepdigest swissprot:TPIS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TPIS_ECOLI pepinfo swissprot:TPIS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TPIS_ECOLI pepnet swissprot:TPIS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TPIS_ECOLI pepstats swissprot:TPIS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TPIS_ECOLI pepwheel swissprot:TPIS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TPIS_ECOLI pepwindow swissprot:TPIS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TPIS_ECOLI sigcleave swissprot:TPIS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TPIS_ECOLI ## Database ID URL or Descriptions # AltName ALF_ECOLI Fructose-1,6-bisphosphate aldolase # AltName ALF_ECOLI Fructose-bisphosphate aldolase class II # BIOPHYSICOCHEMICAL PROPERTIES ALF_ECOLI Kinetic parameters KM=0.17 mM for fructose-1,6-bisphosphate {ECO 0000269|PubMed 10712619}; KM=0.35 mM for tagatose-1,6-bisphosphate {ECO 0000269|PubMed 10712619}; Note=The catalytic efficiency measured with fructose-1,6- bisphosphate as substrate is 1440-fold higher than that with tagatose-1,6-bisphosphate.; # BRENDA 4.1.2.13 2026 # BioGrid 4262069 17 # CATALYTIC ACTIVITY D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. {ECO:0000269|PubMed 10712619}. # CDD cd00946 FBP_aldolase_IIA # COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI 29105; Note=Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.; # EcoGene EG10282 fbaA # FUNCTION ALF_ECOLI Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. {ECO 0000269|PubMed 10712619}. # GO_component GO:0005618 cell wall; IBA:GO_Central. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005886 plasma membrane; IBA:GO_Central. # GO_function GO:0004332 fructose-bisphosphate aldolase activity; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IDA:EcoliWiki. # GO_process GO:0006094 gluconeogenesis; IBA:GO_Central. # GO_process GO:0006096 glycolytic process; IMP:EcoCyc. # GOslim_component GO:0005618 cell wall # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.20.20.70 -; 1. # INTERACTION ALF_ECOLI P0A6Y8 dnaK; NbExp=2; IntAct=EBI-370916, EBI-542092; # IntAct P0AB71 7 # InterPro IPR000771 FBA_II # InterPro IPR006411 Fruct_bisP_bact # InterPro IPR013785 Aldolase_TIM # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00010 Glycolysis / Gluconeogenesis # KEGG_Pathway ko00030 Pentose phosphate pathway # KEGG_Pathway ko00051 Fructose and mannose metabolism # KEGG_Pathway ko00680 Methane metabolism # KEGG_Pathway ko00710 Carbon fixation in photosynthetic organisms # Organism ALF_ECOLI Escherichia coli (strain K12) # PATHWAY Carbohydrate degradation; glycolysis; D-glyceraldehyde 3- phosphate and glycerone phosphate from D-glucose step 4/4. # PATRIC 32121264 VBIEscCol129921_3020 # PDB 1B57 X-ray; 2.00 A; A/B=2-359 # PDB 1DOS X-ray; 1.67 A; A/B=2-359 # PDB 1GYN X-ray; 2.00 A; A=2-359 # PDB 1ZEN X-ray; 2.50 A; A=2-359 # PIR S02177 ADEC2A # PIRSF PIRSF001359 F_bP_aldolase_II # PROSITE PS00602 ALDOLASE_CLASS_II_1 # PROSITE PS00806 ALDOLASE_CLASS_II_2 # Pfam PF01116 F_bP_aldolase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ALF_ECOLI Fructose-bisphosphate aldolase class 2 # RefSeq NP_417400 NC_000913.3 # RefSeq WP_000034372 NZ_LN832404.1 # SIMILARITY Belongs to the class II fructose-bisphosphate aldolase family. {ECO 0000305}. # SUBUNIT ALF_ECOLI Homodimer. {ECO 0000269|PubMed 10080900, ECO 0000269|PubMed 12595741, ECO 0000269|PubMed 8836102, ECO 0000269|PubMed 8939754}. # TIGRFAMs TIGR00167 cbbA # TIGRFAMs TIGR01520 FruBisAldo_II_A # UniPathway UPA00109 UER00183 # eggNOG COG0191 LUCA # eggNOG ENOG4105D2N Bacteria BLAST swissprot:ALF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ALF_ECOLI BioCyc ECOL316407:JW2892-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2892-MONOMER BioCyc EcoCyc:FRUCTBISALD-CLASSII-MONOMER http://biocyc.org/getid?id=EcoCyc:FRUCTBISALD-CLASSII-MONOMER BioCyc MetaCyc:FRUCTBISALD-CLASSII-MONOMER http://biocyc.org/getid?id=MetaCyc:FRUCTBISALD-CLASSII-MONOMER COG COG0191 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0191 DIP DIP-31872N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31872N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1998.1726 http://dx.doi.org/10.1006/jmbi.1998.1726 DOI 10.1006/jmbi.1999.2609 http://dx.doi.org/10.1006/jmbi.1999.2609 DOI 10.1016/0014-5793(93)81317-S http://dx.doi.org/10.1016/0014-5793(93)81317-S DOI 10.1016/S0969-2126(96)00138-4 http://dx.doi.org/10.1016/S0969-2126(96)00138-4 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nchembio.495 http://dx.doi.org/10.1038/nchembio.495 DOI 10.1038/nsb1096-856 http://dx.doi.org/10.1038/nsb1096-856 DOI 10.1042/bj2570529 http://dx.doi.org/10.1042/bj2570529 DOI 10.1046/j.1432-1327.2000.01191.x http://dx.doi.org/10.1046/j.1432-1327.2000.01191.x DOI 10.1074/mcp.M111.012658 http://dx.doi.org/10.1074/mcp.M111.012658 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1107/S0907444902023661 http://dx.doi.org/10.1107/S0907444902023661 DOI 10.1111/j.1365-2958.1989.tb00221.x http://dx.doi.org/10.1111/j.1365-2958.1989.tb00221.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.1.2.13 http://www.genome.jp/dbget-bin/www_bget?EC:4.1.2.13 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EMBL X14436 http://www.ebi.ac.uk/ena/data/view/X14436 ENZYME 4.1.2.13 http://enzyme.expasy.org/EC/4.1.2.13 EchoBASE EB0278 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0278 EcoGene EG10282 http://www.ecogene.org/geneInfo.php?eg_id=EG10282 EnsemblBacteria AAC75962 http://www.ensemblgenomes.org/id/AAC75962 EnsemblBacteria AAC75962 http://www.ensemblgenomes.org/id/AAC75962 EnsemblBacteria BAE76989 http://www.ensemblgenomes.org/id/BAE76989 EnsemblBacteria BAE76989 http://www.ensemblgenomes.org/id/BAE76989 EnsemblBacteria BAE76989 http://www.ensemblgenomes.org/id/BAE76989 EnsemblBacteria b2925 http://www.ensemblgenomes.org/id/b2925 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005618 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0004332 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004332 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_process GO:0006094 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006094 GO_process GO:0006096 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006096 GOslim_component GO:0005618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005618 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 947415 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947415 HOGENOM HOG000227794 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000227794&db=HOGENOM6 InParanoid P0AB71 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AB71 IntAct P0AB71 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AB71* IntEnz 4.1.2.13 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.2.13 InterPro IPR000771 http://www.ebi.ac.uk/interpro/entry/IPR000771 InterPro IPR006411 http://www.ebi.ac.uk/interpro/entry/IPR006411 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2892 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2892 KEGG_Gene eco:b2925 http://www.genome.jp/dbget-bin/www_bget?eco:b2925 KEGG_Orthology KO:K01624 http://www.genome.jp/dbget-bin/www_bget?KO:K01624 KEGG_Pathway ko00010 http://www.genome.jp/kegg-bin/show_pathway?ko00010 KEGG_Pathway ko00030 http://www.genome.jp/kegg-bin/show_pathway?ko00030 KEGG_Pathway ko00051 http://www.genome.jp/kegg-bin/show_pathway?ko00051 KEGG_Pathway ko00680 http://www.genome.jp/kegg-bin/show_pathway?ko00680 KEGG_Pathway ko00710 http://www.genome.jp/kegg-bin/show_pathway?ko00710 KEGG_Reaction rn:R01068 http://www.genome.jp/dbget-bin/www_bget?rn:R01068 KEGG_Reaction rn:R01070 http://www.genome.jp/dbget-bin/www_bget?rn:R01070 KEGG_Reaction rn:R01829 http://www.genome.jp/dbget-bin/www_bget?rn:R01829 KEGG_Reaction rn:R02568 http://www.genome.jp/dbget-bin/www_bget?rn:R02568 OMA RMSKMGM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RMSKMGM PDB 1B57 http://www.ebi.ac.uk/pdbe-srv/view/entry/1B57 PDB 1DOS http://www.ebi.ac.uk/pdbe-srv/view/entry/1DOS PDB 1GYN http://www.ebi.ac.uk/pdbe-srv/view/entry/1GYN PDB 1ZEN http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZEN PDBsum 1B57 http://www.ebi.ac.uk/pdbsum/1B57 PDBsum 1DOS http://www.ebi.ac.uk/pdbsum/1DOS PDBsum 1GYN http://www.ebi.ac.uk/pdbsum/1GYN PDBsum 1ZEN http://www.ebi.ac.uk/pdbsum/1ZEN PROSITE PS00602 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00602 PROSITE PS00806 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00806 PSORT swissprot:ALF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ALF_ECOLI PSORT-B swissprot:ALF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ALF_ECOLI PSORT2 swissprot:ALF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ALF_ECOLI Pfam PF01116 http://pfam.xfam.org/family/PF01116 Phobius swissprot:ALF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ALF_ECOLI PhylomeDB P0AB71 http://phylomedb.org/?seqid=P0AB71 ProteinModelPortal P0AB71 http://www.proteinmodelportal.org/query/uniprot/P0AB71 PubMed 10080900 http://www.ncbi.nlm.nih.gov/pubmed/10080900 PubMed 10712619 http://www.ncbi.nlm.nih.gov/pubmed/10712619 PubMed 12595741 http://www.ncbi.nlm.nih.gov/pubmed/12595741 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 21151122 http://www.ncbi.nlm.nih.gov/pubmed/21151122 PubMed 21908771 http://www.ncbi.nlm.nih.gov/pubmed/21908771 PubMed 2546007 http://www.ncbi.nlm.nih.gov/pubmed/2546007 PubMed 2649077 http://www.ncbi.nlm.nih.gov/pubmed/2649077 PubMed 8436219 http://www.ncbi.nlm.nih.gov/pubmed/8436219 PubMed 8836102 http://www.ncbi.nlm.nih.gov/pubmed/8836102 PubMed 8939754 http://www.ncbi.nlm.nih.gov/pubmed/8939754 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 RefSeq NP_417400 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417400 RefSeq WP_000034372 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000034372 SMR P0AB71 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AB71 STRING 511145.b2925 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2925&targetmode=cogs STRING COG0191 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0191&targetmode=cogs SWISS-2DPAGE P0AB71 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AB71 TIGRFAMs TIGR00167 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00167 TIGRFAMs TIGR01520 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01520 UniProtKB ALF_ECOLI http://www.uniprot.org/uniprot/ALF_ECOLI UniProtKB-AC P0AB71 http://www.uniprot.org/uniprot/P0AB71 charge swissprot:ALF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ALF_ECOLI eggNOG COG0191 http://eggnogapi.embl.de/nog_data/html/tree/COG0191 eggNOG ENOG4105D2N http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D2N epestfind swissprot:ALF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ALF_ECOLI garnier swissprot:ALF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ALF_ECOLI helixturnhelix swissprot:ALF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ALF_ECOLI hmoment swissprot:ALF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ALF_ECOLI iep swissprot:ALF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ALF_ECOLI inforesidue swissprot:ALF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ALF_ECOLI octanol swissprot:ALF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ALF_ECOLI pepcoil swissprot:ALF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ALF_ECOLI pepdigest swissprot:ALF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ALF_ECOLI pepinfo swissprot:ALF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ALF_ECOLI pepnet swissprot:ALF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ALF_ECOLI pepstats swissprot:ALF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ALF_ECOLI pepwheel swissprot:ALF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ALF_ECOLI pepwindow swissprot:ALF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ALF_ECOLI sigcleave swissprot:ALF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ALF_ECOLI ## Database ID URL or Descriptions # BioGrid 4260416 4 # EcoGene EG11895 yeeE # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR007272 Sulf_transp # Organism YEEE_ECOLI Escherichia coli (strain K12) # PATRIC 32119361 VBIEscCol129921_2090 # PIR D64966 D64966 # Pfam PF04143 Sulf_transp # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEEE_ECOLI UPF0394 inner membrane protein YeeE # RefSeq NP_416517 NC_000913.3 # RefSeq WP_000492339 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0394 family. {ECO 0000305}. # SUBCELLULAR LOCATION YEEE_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 9.B.102.1 the yede/yeee (yede/yeee) family # eggNOG COG2391 LUCA # eggNOG ENOG4105CUC Bacteria BLAST swissprot:YEEE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEEE_ECOLI BioCyc ECOL316407:JW1995-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1995-MONOMER BioCyc EcoCyc:EG11895-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11895-MONOMER COG COG2391 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2391 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00009 http://www.ebi.ac.uk/ena/data/view/U00009 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1841 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1841 EcoGene EG11895 http://www.ecogene.org/geneInfo.php?eg_id=EG11895 EnsemblBacteria AAC75074 http://www.ensemblgenomes.org/id/AAC75074 EnsemblBacteria AAC75074 http://www.ensemblgenomes.org/id/AAC75074 EnsemblBacteria BAA15841 http://www.ensemblgenomes.org/id/BAA15841 EnsemblBacteria BAA15841 http://www.ensemblgenomes.org/id/BAA15841 EnsemblBacteria BAA15841 http://www.ensemblgenomes.org/id/BAA15841 EnsemblBacteria b2013 http://www.ensemblgenomes.org/id/b2013 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 946526 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946526 HOGENOM HOG000121907 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000121907&db=HOGENOM6 InParanoid P33015 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33015 InterPro IPR007272 http://www.ebi.ac.uk/interpro/entry/IPR007272 KEGG_Gene ecj:JW1995 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1995 KEGG_Gene eco:b2013 http://www.genome.jp/dbget-bin/www_bget?eco:b2013 KEGG_Orthology KO:K07112 http://www.genome.jp/dbget-bin/www_bget?KO:K07112 OMA AQMLMIG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AQMLMIG PSORT swissprot:YEEE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEEE_ECOLI PSORT-B swissprot:YEEE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEEE_ECOLI PSORT2 swissprot:YEEE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEEE_ECOLI Pfam PF04143 http://pfam.xfam.org/family/PF04143 Phobius swissprot:YEEE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEEE_ECOLI PhylomeDB P33015 http://phylomedb.org/?seqid=P33015 ProteinModelPortal P33015 http://www.proteinmodelportal.org/query/uniprot/P33015 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416517 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416517 RefSeq WP_000492339 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000492339 STRING 511145.b2013 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2013&targetmode=cogs STRING COG2391 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2391&targetmode=cogs TCDB 9.B.102.1 http://www.tcdb.org/search/result.php?tc=9.B.102.1 UniProtKB YEEE_ECOLI http://www.uniprot.org/uniprot/YEEE_ECOLI UniProtKB-AC P33015 http://www.uniprot.org/uniprot/P33015 charge swissprot:YEEE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEEE_ECOLI eggNOG COG2391 http://eggnogapi.embl.de/nog_data/html/tree/COG2391 eggNOG ENOG4105CUC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CUC epestfind swissprot:YEEE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEEE_ECOLI garnier swissprot:YEEE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEEE_ECOLI helixturnhelix swissprot:YEEE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEEE_ECOLI hmoment swissprot:YEEE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEEE_ECOLI iep swissprot:YEEE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEEE_ECOLI inforesidue swissprot:YEEE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEEE_ECOLI octanol swissprot:YEEE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEEE_ECOLI pepcoil swissprot:YEEE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEEE_ECOLI pepdigest swissprot:YEEE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEEE_ECOLI pepinfo swissprot:YEEE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEEE_ECOLI pepnet swissprot:YEEE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEEE_ECOLI pepstats swissprot:YEEE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEEE_ECOLI pepwheel swissprot:YEEE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEEE_ECOLI pepwindow swissprot:YEEE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEEE_ECOLI sigcleave swissprot:YEEE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEEE_ECOLI ## Database ID URL or Descriptions # BioGrid 4262525 10 # CATALYTIC ACTIVITY YHJA_ECOLI 2 ferrocytochrome c + H(2)O(2) = 2 ferricytochrome c + 2 H(2)O. # EcoGene EG12244 yhjA # GO_function GO:0004130 cytochrome-c peroxidase activity; IEA:UniProtKB-EC. # GO_function GO:0009055 electron carrier activity; IEA:InterPro. # GO_function GO:0020037 heme binding; IEA:InterPro. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0042542 response to hydrogen peroxide; IMP:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # Gene3D 1.10.760.10 -; 2. # IntAct P37197 2 # InterPro IPR004852 Di-haem_cyt_c_peroxidsae # InterPro IPR009056 Cyt_c-like_dom # InterPro IPR025992 Haem-bd # KEGG_Brite ko01000 Enzymes # Organism YHJA_ECOLI Escherichia coli (strain K12) # PATRIC 32122498 VBIEscCol129921_3627 # PIR S47738 S47738 # PROSITE PS51007 CYTC; 3 # PTM YHJA_ECOLI Binds 3 heme groups per subunit. {ECO 0000305}. # Pfam PF00034 Cytochrom_C # Pfam PF03150 CCP_MauG # Pfam PF14376 Haem_bd # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHJA_ECOLI Probable cytochrome c peroxidase # RefSeq NP_417975 NC_000913.3 # RefSeq WP_000784827 NZ_LN832404.1 # SMART SM01235 Haem_bd # SUPFAM SSF46626 SSF46626; 2 # eggNOG COG1858 LUCA # eggNOG ENOG4105CA0 Bacteria BLAST swissprot:YHJA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHJA_ECOLI BioCyc ECOL316407:JW3486-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3486-MONOMER BioCyc EcoCyc:EG12244-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12244-MONOMER COG COG1858 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1858 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.11.1.5 http://www.genome.jp/dbget-bin/www_bget?EC:1.11.1.5 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.11.1.5 http://enzyme.expasy.org/EC/1.11.1.5 EchoBASE EB2155 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2155 EcoGene EG12244 http://www.ecogene.org/geneInfo.php?eg_id=EG12244 EnsemblBacteria AAC76543 http://www.ensemblgenomes.org/id/AAC76543 EnsemblBacteria AAC76543 http://www.ensemblgenomes.org/id/AAC76543 EnsemblBacteria BAE77776 http://www.ensemblgenomes.org/id/BAE77776 EnsemblBacteria BAE77776 http://www.ensemblgenomes.org/id/BAE77776 EnsemblBacteria BAE77776 http://www.ensemblgenomes.org/id/BAE77776 EnsemblBacteria b3518 http://www.ensemblgenomes.org/id/b3518 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004130 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004130 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0020037 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0020037 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0042542 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042542 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 1.10.760.10 http://www.cathdb.info/version/latest/superfamily/1.10.760.10 GeneID 948038 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948038 HOGENOM HOG000173943 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000173943&db=HOGENOM6 InParanoid P37197 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37197 IntAct P37197 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37197* IntEnz 1.11.1.5 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.11.1.5 InterPro IPR004852 http://www.ebi.ac.uk/interpro/entry/IPR004852 InterPro IPR009056 http://www.ebi.ac.uk/interpro/entry/IPR009056 InterPro IPR025992 http://www.ebi.ac.uk/interpro/entry/IPR025992 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3486 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3486 KEGG_Gene eco:b3518 http://www.genome.jp/dbget-bin/www_bget?eco:b3518 KEGG_Orthology KO:K00428 http://www.genome.jp/dbget-bin/www_bget?KO:K00428 OMA EMGSHDW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EMGSHDW PROSITE PS51007 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51007 PSORT swissprot:YHJA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHJA_ECOLI PSORT-B swissprot:YHJA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHJA_ECOLI PSORT2 swissprot:YHJA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHJA_ECOLI Pfam PF00034 http://pfam.xfam.org/family/PF00034 Pfam PF03150 http://pfam.xfam.org/family/PF03150 Pfam PF14376 http://pfam.xfam.org/family/PF14376 Phobius swissprot:YHJA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHJA_ECOLI PhylomeDB P37197 http://phylomedb.org/?seqid=P37197 ProteinModelPortal P37197 http://www.proteinmodelportal.org/query/uniprot/P37197 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417975 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417975 RefSeq WP_000784827 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000784827 SMART SM01235 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01235 SMR P37197 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37197 STRING 511145.b3518 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3518&targetmode=cogs STRING COG1858 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1858&targetmode=cogs SUPFAM SSF46626 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46626 UniProtKB YHJA_ECOLI http://www.uniprot.org/uniprot/YHJA_ECOLI UniProtKB-AC P37197 http://www.uniprot.org/uniprot/P37197 charge swissprot:YHJA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHJA_ECOLI eggNOG COG1858 http://eggnogapi.embl.de/nog_data/html/tree/COG1858 eggNOG ENOG4105CA0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CA0 epestfind swissprot:YHJA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHJA_ECOLI garnier swissprot:YHJA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHJA_ECOLI helixturnhelix swissprot:YHJA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHJA_ECOLI hmoment swissprot:YHJA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHJA_ECOLI iep swissprot:YHJA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHJA_ECOLI inforesidue swissprot:YHJA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHJA_ECOLI octanol swissprot:YHJA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHJA_ECOLI pepcoil swissprot:YHJA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHJA_ECOLI pepdigest swissprot:YHJA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHJA_ECOLI pepinfo swissprot:YHJA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHJA_ECOLI pepnet swissprot:YHJA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHJA_ECOLI pepstats swissprot:YHJA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHJA_ECOLI pepwheel swissprot:YHJA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHJA_ECOLI pepwindow swissprot:YHJA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHJA_ECOLI sigcleave swissprot:YHJA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHJA_ECOLI ## Database ID URL or Descriptions # AltName CYNR_ECOLI Cyn operon transcriptional activator # EcoGene EG11421 cynR # FUNCTION CYNR_ECOLI Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region. {ECO 0000269|PubMed 1592818}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # INDUCTION Negatively autoregulated. {ECO:0000269|PubMed 1592818}. # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR005119 LysR_subst-bd # InterPro IPR011991 WHTH_DNA-bd_dom # KEGG_Brite ko03000 Transcription factors # Organism CYNR_ECOLI Escherichia coli (strain K12) # PATRIC 32115809 VBIEscCol129921_0346 # PDB 2HXR X-ray; 2.05 A; A/B=63-299 # PDB 3HFU X-ray; 2.60 A; A/B/C/D=63-299 # PIR A41900 A41900 # PRINTS PR00039 HTHLYSR # PROSITE PS50931 HTH_LYSR # Pfam PF00126 HTH_1 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CYNR_ECOLI HTH-type transcriptional regulator CynR # RefSeq NP_414872 NC_000913.3 # RefSeq WP_000952503 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18062.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Contains 1 HTH lysR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00253}. # SUBCELLULAR LOCATION CYNR_ECOLI Cytoplasm. # SUPFAM SSF46785 SSF46785 # eggNOG ENOG4105DND Bacteria # eggNOG ENOG410YUCG LUCA BLAST swissprot:CYNR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CYNR_ECOLI BioCyc ECOL316407:JW5894-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5894-MONOMER BioCyc EcoCyc:PD00291 http://biocyc.org/getid?id=EcoCyc:PD00291 COG COG0583 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0583 DIP DIP-9364N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9364N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M93053 http://www.ebi.ac.uk/ena/data/view/M93053 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB1391 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1391 EcoGene EG11421 http://www.ecogene.org/geneInfo.php?eg_id=EG11421 EnsemblBacteria AAC73441 http://www.ensemblgenomes.org/id/AAC73441 EnsemblBacteria AAC73441 http://www.ensemblgenomes.org/id/AAC73441 EnsemblBacteria BAE76120 http://www.ensemblgenomes.org/id/BAE76120 EnsemblBacteria BAE76120 http://www.ensemblgenomes.org/id/BAE76120 EnsemblBacteria BAE76120 http://www.ensemblgenomes.org/id/BAE76120 EnsemblBacteria b0338 http://www.ensemblgenomes.org/id/b0338 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 945001 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945001 HOGENOM HOG000233514 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000233514&db=HOGENOM6 InParanoid P27111 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P27111 InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW5894 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5894 KEGG_Gene eco:b0338 http://www.genome.jp/dbget-bin/www_bget?eco:b0338 KEGG_Orthology KO:K11921 http://www.genome.jp/dbget-bin/www_bget?KO:K11921 OMA YLMPRMI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YLMPRMI PDB 2HXR http://www.ebi.ac.uk/pdbe-srv/view/entry/2HXR PDB 3HFU http://www.ebi.ac.uk/pdbe-srv/view/entry/3HFU PDBsum 2HXR http://www.ebi.ac.uk/pdbsum/2HXR PDBsum 3HFU http://www.ebi.ac.uk/pdbsum/3HFU PRINTS PR00039 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00039 PROSITE PS50931 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50931 PSORT swissprot:CYNR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CYNR_ECOLI PSORT-B swissprot:CYNR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CYNR_ECOLI PSORT2 swissprot:CYNR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CYNR_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:CYNR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CYNR_ECOLI PhylomeDB P27111 http://phylomedb.org/?seqid=P27111 ProteinModelPortal P27111 http://www.proteinmodelportal.org/query/uniprot/P27111 PubMed 1592818 http://www.ncbi.nlm.nih.gov/pubmed/1592818 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8253686 http://www.ncbi.nlm.nih.gov/pubmed/8253686 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414872 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414872 RefSeq WP_000952503 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000952503 SMR P27111 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P27111 STRING 511145.b0338 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0338&targetmode=cogs STRING COG0583 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0583&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB CYNR_ECOLI http://www.uniprot.org/uniprot/CYNR_ECOLI UniProtKB-AC P27111 http://www.uniprot.org/uniprot/P27111 charge swissprot:CYNR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CYNR_ECOLI eggNOG ENOG4105DND http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DND eggNOG ENOG410YUCG http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YUCG epestfind swissprot:CYNR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CYNR_ECOLI garnier swissprot:CYNR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CYNR_ECOLI helixturnhelix swissprot:CYNR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CYNR_ECOLI hmoment swissprot:CYNR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CYNR_ECOLI iep swissprot:CYNR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CYNR_ECOLI inforesidue swissprot:CYNR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CYNR_ECOLI octanol swissprot:CYNR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CYNR_ECOLI pepcoil swissprot:CYNR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CYNR_ECOLI pepdigest swissprot:CYNR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CYNR_ECOLI pepinfo swissprot:CYNR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CYNR_ECOLI pepnet swissprot:CYNR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CYNR_ECOLI pepstats swissprot:CYNR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CYNR_ECOLI pepwheel swissprot:CYNR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CYNR_ECOLI pepwindow swissprot:CYNR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CYNR_ECOLI sigcleave swissprot:CYNR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CYNR_ECOLI ## Database ID URL or Descriptions # AltName Transcript cleavage factor GreB {ECO:0000255|HAMAP-Rule MF_00930} # BioGrid 4261264 21 # EcoGene EG11578 greB # FUNCTION GREB_ECOLI Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length. {ECO 0000255|HAMAP-Rule MF_00930, ECO 0000269|PubMed 8431948}. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006352 DNA-templated transcription, initiation; IDA:EcoCyc. # GO_process GO:0031439 positive regulation of mRNA cleavage; IMP:EcoCyc. # GO_process GO:0032784 regulation of DNA-templated transcription, elongation; IDA:EcoCyc. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.287.180 -; 1. # Gene3D 3.10.50.30 -; 1. # HAMAP MF_00105 GreA_GreB # HAMAP MF_00930 GreB # IntAct P30128 24 # InterPro IPR001437 Tscrpt_elong_fac_GreA/B_C # InterPro IPR006358 Tscrpt_elong_fac_GreB # InterPro IPR018151 TF_GreA/GreB_CS # InterPro IPR022691 Tscrpt_elong_fac_GreA/B_N # InterPro IPR023459 Tscrpt_elong_fac_GreA/B_fam # InterPro IPR028624 Tscrpt_elong_fac_GreA/B # KEGG_Brite ko03021 Transcription machinery # Organism GREB_ECOLI Escherichia coli (strain K12) # PATRIC 32122248 VBIEscCol129921_3501 # PDB 2P4V X-ray; 2.60 A; A/B/C/D/E/F=1-158 # PIR A65136 A65136 # PIRSF PIRSF006092 GreA_GreB # PROSITE PS00829 GREAB_1 # PROSITE PS00830 GREAB_2 # Pfam PF01272 GreA_GreB # Pfam PF03449 GreA_GreB_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Transcription elongation factor GreB {ECO:0000255|HAMAP-Rule MF_00930} # RefSeq WP_000856737 NZ_LN832404.1 # RefSeq YP_026216 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA58203.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the GreA/GreB family. GreB subfamily. {ECO:0000255|HAMAP-Rule MF_00930}. # SUPFAM SSF46557 SSF46557 # TIGRFAMs TIGR01461 greB # eggNOG COG0782 LUCA # eggNOG ENOG4108RRZ Bacteria BLAST swissprot:GREB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GREB_ECOLI BioCyc ECOL316407:JW3369-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3369-MONOMER BioCyc EcoCyc:EG11578-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11578-MONOMER COG COG0782 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0782 DIP DIP-9834N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9834N DOI 10.1016/0092-8674(93)90121-6 http://dx.doi.org/10.1016/0092-8674(93)90121-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL U81522 http://www.ebi.ac.uk/ena/data/view/U81522 EchoBASE EB1538 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1538 EcoGene EG11578 http://www.ecogene.org/geneInfo.php?eg_id=EG11578 EnsemblBacteria AAC76431 http://www.ensemblgenomes.org/id/AAC76431 EnsemblBacteria AAC76431 http://www.ensemblgenomes.org/id/AAC76431 EnsemblBacteria BAE77885 http://www.ensemblgenomes.org/id/BAE77885 EnsemblBacteria BAE77885 http://www.ensemblgenomes.org/id/BAE77885 EnsemblBacteria BAE77885 http://www.ensemblgenomes.org/id/BAE77885 EnsemblBacteria b3406 http://www.ensemblgenomes.org/id/b3406 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006352 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006352 GO_process GO:0031439 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031439 GO_process GO:0032784 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032784 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.287.180 http://www.cathdb.info/version/latest/superfamily/1.10.287.180 Gene3D 3.10.50.30 http://www.cathdb.info/version/latest/superfamily/3.10.50.30 GeneID 2847706 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2847706 HAMAP MF_00105 http://hamap.expasy.org/unirule/MF_00105 HAMAP MF_00930 http://hamap.expasy.org/unirule/MF_00930 HOGENOM HOG000241145 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000241145&db=HOGENOM6 InParanoid P30128 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30128 IntAct P30128 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P30128* InterPro IPR001437 http://www.ebi.ac.uk/interpro/entry/IPR001437 InterPro IPR006358 http://www.ebi.ac.uk/interpro/entry/IPR006358 InterPro IPR018151 http://www.ebi.ac.uk/interpro/entry/IPR018151 InterPro IPR022691 http://www.ebi.ac.uk/interpro/entry/IPR022691 InterPro IPR023459 http://www.ebi.ac.uk/interpro/entry/IPR023459 InterPro IPR028624 http://www.ebi.ac.uk/interpro/entry/IPR028624 KEGG_Brite ko03021 http://www.genome.jp/dbget-bin/www_bget?ko03021 KEGG_Gene ecj:JW3369 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3369 KEGG_Gene eco:b3406 http://www.genome.jp/dbget-bin/www_bget?eco:b3406 KEGG_Orthology KO:K04760 http://www.genome.jp/dbget-bin/www_bget?KO:K04760 MINT MINT-1255527 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1255527 OMA DQIFFGA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DQIFFGA PDB 2P4V http://www.ebi.ac.uk/pdbe-srv/view/entry/2P4V PDBsum 2P4V http://www.ebi.ac.uk/pdbsum/2P4V PROSITE PS00829 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00829 PROSITE PS00830 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00830 PSORT swissprot:GREB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GREB_ECOLI PSORT-B swissprot:GREB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GREB_ECOLI PSORT2 swissprot:GREB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GREB_ECOLI Pfam PF01272 http://pfam.xfam.org/family/PF01272 Pfam PF03449 http://pfam.xfam.org/family/PF03449 Phobius swissprot:GREB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GREB_ECOLI PhylomeDB P30128 http://phylomedb.org/?seqid=P30128 ProteinModelPortal P30128 http://www.proteinmodelportal.org/query/uniprot/P30128 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8431948 http://www.ncbi.nlm.nih.gov/pubmed/8431948 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000856737 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000856737 RefSeq YP_026216 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026216 SMR P30128 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P30128 STRING 511145.b3406 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3406&targetmode=cogs STRING COG0782 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0782&targetmode=cogs SUPFAM SSF46557 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46557 TIGRFAMs TIGR01461 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01461 UniProtKB GREB_ECOLI http://www.uniprot.org/uniprot/GREB_ECOLI UniProtKB-AC P30128 http://www.uniprot.org/uniprot/P30128 charge swissprot:GREB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GREB_ECOLI eggNOG COG0782 http://eggnogapi.embl.de/nog_data/html/tree/COG0782 eggNOG ENOG4108RRZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108RRZ epestfind swissprot:GREB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GREB_ECOLI garnier swissprot:GREB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GREB_ECOLI helixturnhelix swissprot:GREB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GREB_ECOLI hmoment swissprot:GREB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GREB_ECOLI iep swissprot:GREB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GREB_ECOLI inforesidue swissprot:GREB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GREB_ECOLI octanol swissprot:GREB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GREB_ECOLI pepcoil swissprot:GREB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GREB_ECOLI pepdigest swissprot:GREB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GREB_ECOLI pepinfo swissprot:GREB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GREB_ECOLI pepnet swissprot:GREB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GREB_ECOLI pepstats swissprot:GREB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GREB_ECOLI pepwheel swissprot:GREB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GREB_ECOLI pepwindow swissprot:GREB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GREB_ECOLI sigcleave swissprot:GREB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GREB_ECOLI ## Database ID URL or Descriptions # AltName MBHS_ECOLI Membrane-bound hydrogenase 1 small subunit # AltName MBHS_ECOLI NiFe hydrogenase # BRENDA 1.12.99 2026 # BioGrid 4261801 9 # CATALYTIC ACTIVITY MBHS_ECOLI H(2) + A = AH(2). # COFACTOR MBHS_ECOLI Name=[3Fe-4S] cluster; Xref=ChEBI CHEBI 21137; Evidence={ECO 0000250}; Note=Binds 1 [3Fe-4S] cluster. {ECO 0000250}; # COFACTOR MBHS_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000250}; Note=Binds 2 [4Fe-4S] clusters. {ECO 0000250}; # EcoGene EG10468 hyaA # FUNCTION MBHS_ECOLI This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD1 is believed to have a role in hydrogen cycling during fermentative growth. # GO_component GO:0009375 ferredoxin hydrogenase complex; IEA:InterPro. # GO_component GO:0016020 membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; ISM:EcoCyc. # GO_component GO:0031237 intrinsic component of periplasmic side of plasma membrane; IDA:EcoCyc. # GO_component GO:0044569 [Ni-Fe] hydrogenase complex; IDA:EcoCyc. # GO_function GO:0008901 ferredoxin hydrogenase activity; IEA:InterPro. # GO_function GO:0009055 electron carrier activity; IDA:EcoCyc. # GO_function GO:0033748 hydrogenase (acceptor) activity; IEA:UniProtKB-EC. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051538 3 iron, 4 sulfur cluster binding; IDA:EcoCyc. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IDA:EcoCyc. # GO_process GO:0006113 fermentation; IEP:EcoCyc. # GO_process GO:0009061 anaerobic respiration; IEP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # Gene3D 3.40.50.700 -; 1. # Gene3D 4.10.480.10 -; 1. # IntAct P69739 2 # InterPro IPR001821 NiFe_hydrogenase_ssu # InterPro IPR006137 NADH_UbQ_OxRdtase-like_20kDa # InterPro IPR006311 TAT_signal # InterPro IPR019546 TAT_signal_bac_arc # InterPro IPR027394 Cytochrome-c3_hydrogenase_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00633 Nitrotoluene degradation # Organism MBHS_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30013 PTHR30013 # PATRIC 32117165 VBIEscCol129921_1006 # PDB 3UQY X-ray; 1.47 A; S/T=46-372 # PDB 3USC X-ray; 2.00 A; S/T=46-372 # PDB 3USE X-ray; 1.67 A; S/T=46-372 # PDB 4GD3 X-ray; 3.30 A; Q/R/S/T=46-372 # PDB 4UE3 X-ray; 1.40 A; S/T=46-372 # PDB 5A4F X-ray; 1.25 A; S/T=46-372 # PDB 5A4I X-ray; 1.23 A; S/T=46-372 # PDB 5A4M X-ray; 1.70 A; S/T=46-311 # PDB 5ADU X-ray; 1.10 A; S/T=46-372 # PIR JV0072 HQECSN # PIRSF PIRSF000310 NiFe_hyd_ssu # PRINTS PR00614 NIHGNASESMLL # PROSITE PS51318 TAT # PTM MBHS_ECOLI Exported by the Tat system. The position of the signal peptide cleavage has been experimentally proven. # Pfam PF01058 Oxidored_q6 # Pfam PF14720 NiFe_hyd_SSU_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MBHS_ECOLI Hydrogenase-1 small chain # RefSeq NP_415491 NC_000913.3 # RefSeq WP_001058323 NZ_LN832404.1 # SIMILARITY Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family. {ECO 0000305}. # SUBCELLULAR LOCATION MBHS_ECOLI Cell inner membrane; Single-pass type I membrane protein; Periplasmic side. # SUBUNIT MBHS_ECOLI Heterodimer of a large and a small subunit. # TIGRFAMs TIGR00391 hydA # TIGRFAMs TIGR01409 TAT_signal_seq # eggNOG COG1740 LUCA # eggNOG ENOG4105E3S Bacteria BLAST swissprot:MBHS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MBHS_ECOLI BioCyc ECOL316407:JW0954-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0954-MONOMER BioCyc EcoCyc:HYAA-MONOMER http://biocyc.org/getid?id=EcoCyc:HYAA-MONOMER BioCyc MetaCyc:HYAA-MONOMER http://biocyc.org/getid?id=MetaCyc:HYAA-MONOMER COG COG1740 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1740 DIP DIP-47848N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47848N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M610507200 http://dx.doi.org/10.1074/jbc.M610507200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.12.99.6 http://www.genome.jp/dbget-bin/www_bget?EC:1.12.99.6 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M34825 http://www.ebi.ac.uk/ena/data/view/M34825 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.12.99.6 http://enzyme.expasy.org/EC/1.12.99.6 EchoBASE EB0463 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0463 EcoGene EG10468 http://www.ecogene.org/geneInfo.php?eg_id=EG10468 EnsemblBacteria AAC74057 http://www.ensemblgenomes.org/id/AAC74057 EnsemblBacteria AAC74057 http://www.ensemblgenomes.org/id/AAC74057 EnsemblBacteria BAA35737 http://www.ensemblgenomes.org/id/BAA35737 EnsemblBacteria BAA35737 http://www.ensemblgenomes.org/id/BAA35737 EnsemblBacteria BAA35737 http://www.ensemblgenomes.org/id/BAA35737 EnsemblBacteria b0972 http://www.ensemblgenomes.org/id/b0972 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009375 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009375 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0031237 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031237 GO_component GO:0044569 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044569 GO_function GO:0008901 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008901 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0033748 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033748 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051538 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051538 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0006113 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006113 GO_process GO:0009061 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009061 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 Gene3D 3.40.50.700 http://www.cathdb.info/version/latest/superfamily/3.40.50.700 Gene3D 4.10.480.10 http://www.cathdb.info/version/latest/superfamily/4.10.480.10 GeneID 945579 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945579 HOGENOM HOG000278822 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278822&db=HOGENOM6 InParanoid P69739 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P69739 IntAct P69739 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69739* IntEnz 1.12.99.6 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.12.99.6 InterPro IPR001821 http://www.ebi.ac.uk/interpro/entry/IPR001821 InterPro IPR006137 http://www.ebi.ac.uk/interpro/entry/IPR006137 InterPro IPR006311 http://www.ebi.ac.uk/interpro/entry/IPR006311 InterPro IPR019546 http://www.ebi.ac.uk/interpro/entry/IPR019546 InterPro IPR027394 http://www.ebi.ac.uk/interpro/entry/IPR027394 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0954 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0954 KEGG_Gene eco:b0972 http://www.genome.jp/dbget-bin/www_bget?eco:b0972 KEGG_Orthology KO:K06282 http://www.genome.jp/dbget-bin/www_bget?KO:K06282 KEGG_Pathway ko00633 http://www.genome.jp/kegg-bin/show_pathway?ko00633 KEGG_Reaction rn:R08034 http://www.genome.jp/dbget-bin/www_bget?rn:R08034 OMA MFVESFD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MFVESFD PANTHER PTHR30013 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30013 PDB 3UQY http://www.ebi.ac.uk/pdbe-srv/view/entry/3UQY PDB 3USC http://www.ebi.ac.uk/pdbe-srv/view/entry/3USC PDB 3USE http://www.ebi.ac.uk/pdbe-srv/view/entry/3USE PDB 4GD3 http://www.ebi.ac.uk/pdbe-srv/view/entry/4GD3 PDB 4UE3 http://www.ebi.ac.uk/pdbe-srv/view/entry/4UE3 PDB 5A4F http://www.ebi.ac.uk/pdbe-srv/view/entry/5A4F PDB 5A4I http://www.ebi.ac.uk/pdbe-srv/view/entry/5A4I PDB 5A4M http://www.ebi.ac.uk/pdbe-srv/view/entry/5A4M PDB 5ADU http://www.ebi.ac.uk/pdbe-srv/view/entry/5ADU PDBsum 3UQY http://www.ebi.ac.uk/pdbsum/3UQY PDBsum 3USC http://www.ebi.ac.uk/pdbsum/3USC PDBsum 3USE http://www.ebi.ac.uk/pdbsum/3USE PDBsum 4GD3 http://www.ebi.ac.uk/pdbsum/4GD3 PDBsum 4UE3 http://www.ebi.ac.uk/pdbsum/4UE3 PDBsum 5A4F http://www.ebi.ac.uk/pdbsum/5A4F PDBsum 5A4I http://www.ebi.ac.uk/pdbsum/5A4I PDBsum 5A4M http://www.ebi.ac.uk/pdbsum/5A4M PDBsum 5ADU http://www.ebi.ac.uk/pdbsum/5ADU PRINTS PR00614 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00614 PROSITE PS51318 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51318 PSORT swissprot:MBHS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MBHS_ECOLI PSORT-B swissprot:MBHS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MBHS_ECOLI PSORT2 swissprot:MBHS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MBHS_ECOLI Pfam PF01058 http://pfam.xfam.org/family/PF01058 Pfam PF14720 http://pfam.xfam.org/family/PF14720 Phobius swissprot:MBHS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MBHS_ECOLI PhylomeDB P69739 http://phylomedb.org/?seqid=P69739 ProteinModelPortal P69739 http://www.proteinmodelportal.org/query/uniprot/P69739 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17218314 http://www.ncbi.nlm.nih.gov/pubmed/17218314 PubMed 2180913 http://www.ncbi.nlm.nih.gov/pubmed/2180913 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415491 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415491 RefSeq WP_001058323 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001058323 SMR P69739 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69739 STRING 511145.b0972 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0972&targetmode=cogs STRING COG1740 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1740&targetmode=cogs TIGRFAMs TIGR00391 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00391 TIGRFAMs TIGR01409 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01409 UniProtKB MBHS_ECOLI http://www.uniprot.org/uniprot/MBHS_ECOLI UniProtKB-AC P69739 http://www.uniprot.org/uniprot/P69739 charge swissprot:MBHS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MBHS_ECOLI eggNOG COG1740 http://eggnogapi.embl.de/nog_data/html/tree/COG1740 eggNOG ENOG4105E3S http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E3S epestfind swissprot:MBHS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MBHS_ECOLI garnier swissprot:MBHS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MBHS_ECOLI helixturnhelix swissprot:MBHS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MBHS_ECOLI hmoment swissprot:MBHS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MBHS_ECOLI iep swissprot:MBHS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MBHS_ECOLI inforesidue swissprot:MBHS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MBHS_ECOLI octanol swissprot:MBHS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MBHS_ECOLI pepcoil swissprot:MBHS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MBHS_ECOLI pepdigest swissprot:MBHS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MBHS_ECOLI pepinfo swissprot:MBHS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MBHS_ECOLI pepnet swissprot:MBHS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MBHS_ECOLI pepstats swissprot:MBHS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MBHS_ECOLI pepwheel swissprot:MBHS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MBHS_ECOLI pepwindow swissprot:MBHS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MBHS_ECOLI sigcleave swissprot:MBHS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MBHS_ECOLI ## Database ID URL or Descriptions # BioGrid 4262880 6 # EcoGene EG13354 smrA # FUNCTION SMRA_ECOLI Has DNA endonuclease activity. Binds DNA. {ECO 0000269|PubMed 21276852}. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0004520 endodeoxyribonuclease activity; IDA:EcoCyc. # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004518 nuclease activity # InterPro IPR002625 Smr_dom # Organism SMRA_ECOLI Escherichia coli (strain K12) # PATRIC 32117958 VBIEscCol129921_1399 # PDB 3QD7 X-ray; 2.30 A; X=39-175 # PIR G64883 G64883 # PROSITE PS50828 SMR # Pfam PF01713 Smr # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SMRA_ECOLI Probable DNA endonuclease SmrA # RefSeq NP_415856 NC_000913.3 # RefSeq WP_001046829 NZ_LN832404.1 # SIMILARITY Contains 1 Smr domain. {ECO:0000255|PROSITE- ProRule PRU00321}. # SMART SM00463 SMR # SUPFAM SSF160443 SSF160443 # eggNOG COG2840 LUCA # eggNOG ENOG4108DG9 Bacteria BLAST swissprot:SMRA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SMRA_ECOLI BioCyc ECOL316407:JW1334-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1334-MONOMER BioCyc EcoCyc:G6672-MONOMER http://biocyc.org/getid?id=EcoCyc:G6672-MONOMER DOI 10.1016/j.jsb.2011.01.008 http://dx.doi.org/10.1016/j.jsb.2011.01.008 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.-.- http://enzyme.expasy.org/EC/3.1.-.- EchoBASE EB3137 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3137 EcoGene EG13354 http://www.ecogene.org/geneInfo.php?eg_id=EG13354 EnsemblBacteria AAC74422 http://www.ensemblgenomes.org/id/AAC74422 EnsemblBacteria AAC74422 http://www.ensemblgenomes.org/id/AAC74422 EnsemblBacteria BAE76405 http://www.ensemblgenomes.org/id/BAE76405 EnsemblBacteria BAE76405 http://www.ensemblgenomes.org/id/BAE76405 EnsemblBacteria BAE76405 http://www.ensemblgenomes.org/id/BAE76405 EnsemblBacteria b1340 http://www.ensemblgenomes.org/id/b1340 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004520 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GeneID 945953 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945953 HOGENOM HOG000257489 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000257489&db=HOGENOM6 InParanoid P76053 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76053 IntAct P76053 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76053* IntEnz 3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1 InterPro IPR002625 http://www.ebi.ac.uk/interpro/entry/IPR002625 KEGG_Gene ecj:JW1334 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1334 KEGG_Gene eco:b1340 http://www.genome.jp/dbget-bin/www_bget?eco:b1340 OMA DDSHANI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DDSHANI PDB 3QD7 http://www.ebi.ac.uk/pdbe-srv/view/entry/3QD7 PDBsum 3QD7 http://www.ebi.ac.uk/pdbsum/3QD7 PROSITE PS50828 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50828 PSORT swissprot:SMRA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SMRA_ECOLI PSORT-B swissprot:SMRA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SMRA_ECOLI PSORT2 swissprot:SMRA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SMRA_ECOLI Pfam PF01713 http://pfam.xfam.org/family/PF01713 Phobius swissprot:SMRA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SMRA_ECOLI PhylomeDB P76053 http://phylomedb.org/?seqid=P76053 ProteinModelPortal P76053 http://www.proteinmodelportal.org/query/uniprot/P76053 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21276852 http://www.ncbi.nlm.nih.gov/pubmed/21276852 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415856 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415856 RefSeq WP_001046829 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001046829 SMART SM00463 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00463 SMR P76053 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76053 STRING 511145.b1340 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1340&targetmode=cogs SUPFAM SSF160443 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF160443 UniProtKB SMRA_ECOLI http://www.uniprot.org/uniprot/SMRA_ECOLI UniProtKB-AC P76053 http://www.uniprot.org/uniprot/P76053 charge swissprot:SMRA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SMRA_ECOLI eggNOG COG2840 http://eggnogapi.embl.de/nog_data/html/tree/COG2840 eggNOG ENOG4108DG9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108DG9 epestfind swissprot:SMRA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SMRA_ECOLI garnier swissprot:SMRA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SMRA_ECOLI helixturnhelix swissprot:SMRA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SMRA_ECOLI hmoment swissprot:SMRA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SMRA_ECOLI iep swissprot:SMRA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SMRA_ECOLI inforesidue swissprot:SMRA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SMRA_ECOLI octanol swissprot:SMRA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SMRA_ECOLI pepcoil swissprot:SMRA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SMRA_ECOLI pepdigest swissprot:SMRA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SMRA_ECOLI pepinfo swissprot:SMRA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SMRA_ECOLI pepnet swissprot:SMRA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SMRA_ECOLI pepstats swissprot:SMRA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SMRA_ECOLI pepwheel swissprot:SMRA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SMRA_ECOLI pepwindow swissprot:SMRA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SMRA_ECOLI sigcleave swissprot:SMRA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SMRA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261780 11 # EcoGene EG11467 yigI # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # Gene3D 3.10.129.10 -; 1. # InterPro IPR003736 PAAI_dom # InterPro IPR006683 Thioestr_dom # InterPro IPR029069 HotDog_dom # Organism YIGI_ECOLI Escherichia coli (strain K12) # PATRIC 32123141 VBIEscCol129921_3936 # Pfam PF03061 4HBT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIGI_ECOLI Uncharacterized protein YigI # RefSeq NP_418264 NC_000913.3 # RefSeq WP_001277142 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA67616.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAD15042.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SUPFAM SSF54637 SSF54637 # TIGRFAMs TIGR00369 unchar_dom_1 # eggNOG COG2050 LUCA # eggNOG ENOG4108VUY Bacteria BLAST swissprot:YIGI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIGI_ECOLI BioCyc ECOL316407:JW5588-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5588-MONOMER BioCyc EcoCyc:EG11467-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11467-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L02122 http://www.ebi.ac.uk/ena/data/view/L02122 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X02143 http://www.ebi.ac.uk/ena/data/view/X02143 EchoBASE EB1435 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1435 EcoGene EG11467 http://www.ecogene.org/geneInfo.php?eg_id=EG11467 EnsemblBacteria AAC76823 http://www.ensemblgenomes.org/id/AAC76823 EnsemblBacteria AAC76823 http://www.ensemblgenomes.org/id/AAC76823 EnsemblBacteria BAE77481 http://www.ensemblgenomes.org/id/BAE77481 EnsemblBacteria BAE77481 http://www.ensemblgenomes.org/id/BAE77481 EnsemblBacteria BAE77481 http://www.ensemblgenomes.org/id/BAE77481 EnsemblBacteria b3820 http://www.ensemblgenomes.org/id/b3820 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 Gene3D 3.10.129.10 http://www.cathdb.info/version/latest/superfamily/3.10.129.10 GeneID 948338 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948338 HOGENOM HOG000066992 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000066992&db=HOGENOM6 InParanoid P0ADP2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADP2 InterPro IPR003736 http://www.ebi.ac.uk/interpro/entry/IPR003736 InterPro IPR006683 http://www.ebi.ac.uk/interpro/entry/IPR006683 InterPro IPR029069 http://www.ebi.ac.uk/interpro/entry/IPR029069 KEGG_Gene ecj:JW5588 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5588 KEGG_Gene eco:b3820 http://www.genome.jp/dbget-bin/www_bget?eco:b3820 OMA YHMPFNQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YHMPFNQ PSORT swissprot:YIGI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIGI_ECOLI PSORT-B swissprot:YIGI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIGI_ECOLI PSORT2 swissprot:YIGI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIGI_ECOLI Pfam PF03061 http://pfam.xfam.org/family/PF03061 Phobius swissprot:YIGI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIGI_ECOLI PhylomeDB P0ADP2 http://phylomedb.org/?seqid=P0ADP2 ProteinModelPortal P0ADP2 http://www.proteinmodelportal.org/query/uniprot/P0ADP2 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6397464 http://www.ncbi.nlm.nih.gov/pubmed/6397464 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418264 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418264 RefSeq WP_001277142 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001277142 SMR P0ADP2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADP2 STRING 511145.b3820 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3820&targetmode=cogs SUPFAM SSF54637 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54637 TIGRFAMs TIGR00369 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00369 UniProtKB YIGI_ECOLI http://www.uniprot.org/uniprot/YIGI_ECOLI UniProtKB-AC P0ADP2 http://www.uniprot.org/uniprot/P0ADP2 charge swissprot:YIGI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIGI_ECOLI eggNOG COG2050 http://eggnogapi.embl.de/nog_data/html/tree/COG2050 eggNOG ENOG4108VUY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108VUY epestfind swissprot:YIGI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIGI_ECOLI garnier swissprot:YIGI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIGI_ECOLI helixturnhelix swissprot:YIGI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIGI_ECOLI hmoment swissprot:YIGI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIGI_ECOLI iep swissprot:YIGI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIGI_ECOLI inforesidue swissprot:YIGI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIGI_ECOLI octanol swissprot:YIGI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIGI_ECOLI pepcoil swissprot:YIGI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIGI_ECOLI pepdigest swissprot:YIGI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIGI_ECOLI pepinfo swissprot:YIGI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIGI_ECOLI pepnet swissprot:YIGI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIGI_ECOLI pepstats swissprot:YIGI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIGI_ECOLI pepwheel swissprot:YIGI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIGI_ECOLI pepwindow swissprot:YIGI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIGI_ECOLI sigcleave swissprot:YIGI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIGI_ECOLI ## Database ID URL or Descriptions # BioGrid 4262107 228 # DISRUPTION PHENOTYPE Null mutation results in the accumulation of lipid III and cell death. {ECO:0000269|PubMed 12621029}. # EcoGene EG11486 wzxE # FUNCTION WZXE_ECOLI Mediates the transbilayer movement of Und-PP-GlcNAc- ManNAcA-Fuc4NAc (lipid III) from the inner to the outer leaflet of the cytoplasmic membrane during the assembly of enterobacterial common antigen (ECA). Required for the assembly of the phosphoglyceride-linked form of ECA (ECA(PG)) and the water- soluble cyclic form of ECA (ECA(CYC)). Could also mediate the translocation of Und-PP-GlcNAc. {ECO 0000269|PubMed 12621029, ECO 0000269|PubMed 16199561}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IEA:UniProtKB-HAMAP. # GO_process GO:0006810 transport; IBA:GO_Central. # GO_process GO:0009246 enterobacterial common antigen biosynthetic process; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006810 transport # GOslim_process GO:0009058 biosynthetic process # HAMAP MF_02024 WzxE # InterPro IPR002797 Polysacc_synth # InterPro IPR032896 WzxE # KEGG_Brite ko02000 Transporters # Organism WZXE_ECOLI Escherichia coli (strain K12) # PATHWAY WZXE_ECOLI Bacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis. {ECO 0000255|HAMAP-Rule MF_02024, ECO 0000269|PubMed 12621029, ECO 0000269|PubMed 16199561}. # PATRIC 32123077 VBIEscCol129921_3908 # PIR C65183 C65183 # Pfam PF01943 Polysacc_synt # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Lipid III flippase {ECO:0000255|HAMAP-Rule MF_02024, ECO:0000305} # RefSeq NP_418239 NC_000913.3 # RefSeq WP_000050265 NZ_LN832404.1 # SIMILARITY Belongs to the polysaccharide transport (PST) (TC 2.A.66.2) family. {ECO:0000255|HAMAP-Rule MF_02024, ECO:0000305}. # SUBCELLULAR LOCATION WZXE_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_02024, ECO 0000305}; Multi-pass membrane protein {ECO 0000255|HAMAP-Rule MF_02024}. # SUBUNIT WZXE_ECOLI Probably part of a complex composed of WzxE, WzyE and WzzE. {ECO 0000255|HAMAP-Rule MF_02024, ECO 0000305|PubMed 16816184}. # TCDB 2.A.66.2 the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily # eggNOG COG2244 LUCA # eggNOG ENOG4105EGZ Bacteria BLAST swissprot:WZXE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:WZXE_ECOLI BioCyc ECOL316407:JW3766-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3766-MONOMER BioCyc EcoCyc:EG11486-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11486-MONOMER BioCyc MetaCyc:EG11486-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11486-MONOMER COG COG2244 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2244 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M301750200 http://dx.doi.org/10.1074/jbc.M301750200 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00461-06 http://dx.doi.org/10.1128/JB.00461-06 DOI 10.1128/JB.187.20.6917-6927.2005 http://dx.doi.org/10.1128/JB.187.20.6917-6927.2005 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1449 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1449 EcoGene EG11486 http://www.ecogene.org/geneInfo.php?eg_id=EG11486 EnsemblBacteria AAC76797 http://www.ensemblgenomes.org/id/AAC76797 EnsemblBacteria AAC76797 http://www.ensemblgenomes.org/id/AAC76797 EnsemblBacteria BAE77506 http://www.ensemblgenomes.org/id/BAE77506 EnsemblBacteria BAE77506 http://www.ensemblgenomes.org/id/BAE77506 EnsemblBacteria BAE77506 http://www.ensemblgenomes.org/id/BAE77506 EnsemblBacteria b3792 http://www.ensemblgenomes.org/id/b3792 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GO_process GO:0009246 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009246 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 948294 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948294 HAMAP MF_02024 http://hamap.expasy.org/unirule/MF_02024 HOGENOM HOG000126459 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126459&db=HOGENOM6 InParanoid P0AAA7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAA7 InterPro IPR002797 http://www.ebi.ac.uk/interpro/entry/IPR002797 InterPro IPR032896 http://www.ebi.ac.uk/interpro/entry/IPR032896 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3766 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3766 KEGG_Gene eco:b3792 http://www.genome.jp/dbget-bin/www_bget?eco:b3792 KEGG_Orthology KO:K16693 http://www.genome.jp/dbget-bin/www_bget?KO:K16693 OMA YICFRIG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YICFRIG PSORT swissprot:WZXE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:WZXE_ECOLI PSORT-B swissprot:WZXE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:WZXE_ECOLI PSORT2 swissprot:WZXE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:WZXE_ECOLI Pfam PF01943 http://pfam.xfam.org/family/PF01943 Phobius swissprot:WZXE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:WZXE_ECOLI ProteinModelPortal P0AAA7 http://www.proteinmodelportal.org/query/uniprot/P0AAA7 PubMed 12621029 http://www.ncbi.nlm.nih.gov/pubmed/12621029 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16199561 http://www.ncbi.nlm.nih.gov/pubmed/16199561 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16816184 http://www.ncbi.nlm.nih.gov/pubmed/16816184 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418239 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418239 RefSeq WP_000050265 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000050265 STRING 511145.b3792 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3792&targetmode=cogs STRING COG2244 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2244&targetmode=cogs TCDB 2.A.66.2 http://www.tcdb.org/search/result.php?tc=2.A.66.2 UniProtKB WZXE_ECOLI http://www.uniprot.org/uniprot/WZXE_ECOLI UniProtKB-AC P0AAA7 http://www.uniprot.org/uniprot/P0AAA7 charge swissprot:WZXE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:WZXE_ECOLI eggNOG COG2244 http://eggnogapi.embl.de/nog_data/html/tree/COG2244 eggNOG ENOG4105EGZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EGZ epestfind swissprot:WZXE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:WZXE_ECOLI garnier swissprot:WZXE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:WZXE_ECOLI helixturnhelix swissprot:WZXE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:WZXE_ECOLI hmoment swissprot:WZXE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:WZXE_ECOLI iep swissprot:WZXE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:WZXE_ECOLI inforesidue swissprot:WZXE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:WZXE_ECOLI octanol swissprot:WZXE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:WZXE_ECOLI pepcoil swissprot:WZXE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:WZXE_ECOLI pepdigest swissprot:WZXE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:WZXE_ECOLI pepinfo swissprot:WZXE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:WZXE_ECOLI pepnet swissprot:WZXE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:WZXE_ECOLI pepstats swissprot:WZXE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:WZXE_ECOLI pepwheel swissprot:WZXE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:WZXE_ECOLI pepwindow swissprot:WZXE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:WZXE_ECOLI sigcleave swissprot:WZXE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:WZXE_ECOLI ## Database ID URL or Descriptions # AltName RNPH_ECOLI tRNA nucleotidyltransferase # CATALYTIC ACTIVITY RNPH_ECOLI tRNA(n+1) + phosphate = tRNA(n) + a nucleoside diphosphate. # CDD cd11362 RNase_PH_bact # EcoGene EG10863 rph # FUNCTION RNPH_ECOLI Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates. Also acts to regulate the attenuation of PyrE. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000049 tRNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0004527 exonuclease activity; IDA:EcoCyc. # GO_function GO:0009022 tRNA nucleotidyltransferase activity; IDA:EcoCyc. # GO_process GO:0006399 tRNA metabolic process; EXP:EcoCyc. # GO_process GO:0016075 rRNA catabolic process; IBA:GO_Central. # GO_process GO:0042780 tRNA 3'-end processing; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0004518 nuclease activity # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # Gene3D 3.30.230.70 -; 1. # HAMAP MF_00564 RNase_PH # IntAct P0CG19 8 # InterPro IPR001247 ExoRNase_PH_dom1 # InterPro IPR002381 RNase_PH_bac-type # InterPro IPR015847 ExoRNase_PH_dom2 # InterPro IPR018336 RNase_PH_CS # InterPro IPR020568 Ribosomal_S5_D2-typ_fold # InterPro IPR027408 PNPase/RNase_PH_dom # MISCELLANEOUS RNPH_ECOLI The gene in K12 strains MG1655 and W3110 (and also other derivatives of K12 W1485) has a frameshift mutation that leads to loss of activity, although the protein is translated. Thus in those strains rph is an expressed but non-functional pseudogene. For the functional protein without the frameshift mutation see AC P0CG18. # Organism RNPH_ECOLI Escherichia coli (strain K12) # PATRIC 32122773 VBIEscCol129921_3763 # PIR A04470 QQECPE # PROSITE PS01277 RIBONUCLEASE_PH # Pfam PF01138 RNase_PH # Pfam PF03725 RNase_PH_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RNPH_ECOLI Inactive ribonuclease PH # SIMILARITY Belongs to the RNase PH family. {ECO 0000305}. # SUBUNIT Homodimer. {ECO 0000250}. # SUPFAM SSF54211 SSF54211 # SUPFAM SSF55666 SSF55666 # TIGRFAMs TIGR01966 RNasePH # eggNOG COG0689 LUCA # eggNOG ENOG4105ED0 Bacteria BLAST swissprot:RNPH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RNPH_ECOLI BioCyc EcoCyc:EG10863-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10863-MONOMER BioCyc MetaCyc:EG10863-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10863-MONOMER DIP DIP-10738N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10738N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.7.56 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.56 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V01578 http://www.ebi.ac.uk/ena/data/view/V01578 EMBL X72920 http://www.ebi.ac.uk/ena/data/view/X72920 ENZYME 2.7.7.56 http://enzyme.expasy.org/EC/2.7.7.56 EcoGene EG10863 http://www.ecogene.org/geneInfo.php?eg_id=EG10863 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000049 GO_function GO:0004527 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004527 GO_function GO:0009022 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009022 GO_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GO_process GO:0016075 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016075 GO_process GO:0042780 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042780 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 Gene3D 3.30.230.70 http://www.cathdb.info/version/latest/superfamily/3.30.230.70 HAMAP MF_00564 http://hamap.expasy.org/unirule/MF_00564 InParanoid P0CG19 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CG19 IntAct P0CG19 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0CG19* IntEnz 2.7.7.56 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.56 InterPro IPR001247 http://www.ebi.ac.uk/interpro/entry/IPR001247 InterPro IPR002381 http://www.ebi.ac.uk/interpro/entry/IPR002381 InterPro IPR015847 http://www.ebi.ac.uk/interpro/entry/IPR015847 InterPro IPR018336 http://www.ebi.ac.uk/interpro/entry/IPR018336 InterPro IPR020568 http://www.ebi.ac.uk/interpro/entry/IPR020568 InterPro IPR027408 http://www.ebi.ac.uk/interpro/entry/IPR027408 MINT MINT-1233748 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1233748 PROSITE PS01277 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01277 PSORT swissprot:RNPH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RNPH_ECOLI PSORT-B swissprot:RNPH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RNPH_ECOLI PSORT2 swissprot:RNPH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RNPH_ECOLI Pfam PF01138 http://pfam.xfam.org/family/PF01138 Pfam PF03725 http://pfam.xfam.org/family/PF03725 Phobius swissprot:RNPH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RNPH_ECOLI ProteinModelPortal P0CG19 http://www.proteinmodelportal.org/query/uniprot/P0CG19 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 8501045 http://www.ncbi.nlm.nih.gov/pubmed/8501045 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SMR P0CG19 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0CG19 STRING 511145.b3643 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3643&targetmode=cogs SUPFAM SSF54211 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54211 SUPFAM SSF55666 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55666 TIGRFAMs TIGR01966 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01966 UniProtKB RNPH_ECOLI http://www.uniprot.org/uniprot/RNPH_ECOLI UniProtKB-AC P0CG19 http://www.uniprot.org/uniprot/P0CG19 charge swissprot:RNPH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RNPH_ECOLI eggNOG COG0689 http://eggnogapi.embl.de/nog_data/html/tree/COG0689 eggNOG ENOG4105ED0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ED0 epestfind swissprot:RNPH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RNPH_ECOLI garnier swissprot:RNPH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RNPH_ECOLI helixturnhelix swissprot:RNPH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RNPH_ECOLI hmoment swissprot:RNPH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RNPH_ECOLI iep swissprot:RNPH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RNPH_ECOLI inforesidue swissprot:RNPH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RNPH_ECOLI octanol swissprot:RNPH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RNPH_ECOLI pepcoil swissprot:RNPH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RNPH_ECOLI pepdigest swissprot:RNPH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RNPH_ECOLI pepinfo swissprot:RNPH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RNPH_ECOLI pepnet swissprot:RNPH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RNPH_ECOLI pepstats swissprot:RNPH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RNPH_ECOLI pepwheel swissprot:RNPH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RNPH_ECOLI pepwindow swissprot:RNPH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RNPH_ECOLI sigcleave swissprot:RNPH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RNPH_ECOLI ## Database ID URL or Descriptions # BioGrid 4261141 145 # EcoGene EG11890 slp # FUNCTION SLP_ECOLI The induction of slp may help to stabilize the outer membrane during carbon starvation and stationary phase. # GO_component GO:0009279 cell outer membrane; IEA:UniProtKB-SubCell. # GO_component GO:0019867 outer membrane; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # INDUCTION SLP_ECOLI Induced upon starvation and slowed growth. cAMP/CRP- independent. # INTERACTION SLP_ECOLI Self; NbExp=2; IntAct=EBI-907245, EBI-907245; # IntAct P37194 4 # InterPro IPR004658 OMP_Slp # Organism SLP_ECOLI Escherichia coli (strain K12) # PATRIC 32122470 VBIEscCol129921_3613 # PIR S47726 S47726 # PIRSF PIRSF004982 SlP # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF03843 Slp # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SLP_ECOLI Outer membrane protein slp # RefSeq NP_417963 NC_000913.3 # RefSeq WP_001350553 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18482.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SUBCELLULAR LOCATION SLP_ECOLI Cell outer membrane {ECO 0000269|PubMed 16079137}; Lipid-anchor {ECO 0000255|PROSITE- ProRule PRU00303, ECO 0000269|PubMed 16079137}. # SUBUNIT Forms homooligomers. {ECO:0000269|PubMed 16079137}. # TIGRFAMs TIGR00752 slp # eggNOG COG3065 LUCA # eggNOG ENOG4105Y4Z Bacteria BLAST swissprot:SLP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SLP_ECOLI BioCyc ECOL316407:JW3474-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3474-MONOMER BioCyc EcoCyc:EG11890-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11890-MONOMER COG COG3065 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3065 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1111/j.1365-2958.1994.tb00383.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb00383.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L23635 http://www.ebi.ac.uk/ena/data/view/L23635 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1836 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1836 EcoGene EG11890 http://www.ecogene.org/geneInfo.php?eg_id=EG11890 EnsemblBacteria AAC76531 http://www.ensemblgenomes.org/id/AAC76531 EnsemblBacteria AAC76531 http://www.ensemblgenomes.org/id/AAC76531 EnsemblBacteria BAE77788 http://www.ensemblgenomes.org/id/BAE77788 EnsemblBacteria BAE77788 http://www.ensemblgenomes.org/id/BAE77788 EnsemblBacteria BAE77788 http://www.ensemblgenomes.org/id/BAE77788 EnsemblBacteria b3506 http://www.ensemblgenomes.org/id/b3506 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0019867 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019867 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GeneID 948022 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948022 HOGENOM HOG000277549 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000277549&db=HOGENOM6 InParanoid P37194 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37194 IntAct P37194 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37194* InterPro IPR004658 http://www.ebi.ac.uk/interpro/entry/IPR004658 KEGG_Gene ecj:JW3474 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3474 KEGG_Gene eco:b3506 http://www.genome.jp/dbget-bin/www_bget?eco:b3506 KEGG_Orthology KO:K07285 http://www.genome.jp/dbget-bin/www_bget?KO:K07285 OMA FIACRAG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FIACRAG PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:SLP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SLP_ECOLI PSORT-B swissprot:SLP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SLP_ECOLI PSORT2 swissprot:SLP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SLP_ECOLI Pfam PF03843 http://pfam.xfam.org/family/PF03843 Phobius swissprot:SLP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SLP_ECOLI PhylomeDB P37194 http://phylomedb.org/?seqid=P37194 ProteinModelPortal P37194 http://www.proteinmodelportal.org/query/uniprot/P37194 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8022277 http://www.ncbi.nlm.nih.gov/pubmed/8022277 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417963 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417963 RefSeq WP_001350553 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001350553 STRING 511145.b3506 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3506&targetmode=cogs STRING COG3065 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3065&targetmode=cogs TIGRFAMs TIGR00752 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00752 UniProtKB SLP_ECOLI http://www.uniprot.org/uniprot/SLP_ECOLI UniProtKB-AC P37194 http://www.uniprot.org/uniprot/P37194 charge swissprot:SLP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SLP_ECOLI eggNOG COG3065 http://eggnogapi.embl.de/nog_data/html/tree/COG3065 eggNOG ENOG4105Y4Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105Y4Z epestfind swissprot:SLP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SLP_ECOLI garnier swissprot:SLP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SLP_ECOLI helixturnhelix swissprot:SLP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SLP_ECOLI hmoment swissprot:SLP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SLP_ECOLI iep swissprot:SLP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SLP_ECOLI inforesidue swissprot:SLP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SLP_ECOLI octanol swissprot:SLP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SLP_ECOLI pepcoil swissprot:SLP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SLP_ECOLI pepdigest swissprot:SLP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SLP_ECOLI pepinfo swissprot:SLP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SLP_ECOLI pepnet swissprot:SLP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SLP_ECOLI pepstats swissprot:SLP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SLP_ECOLI pepwheel swissprot:SLP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SLP_ECOLI pepwindow swissprot:SLP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SLP_ECOLI sigcleave swissprot:SLP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SLP_ECOLI ## Database ID URL or Descriptions # AltName HSRA_ECOLI High-copy suppressor of rspA # BioGrid 4262603 136 # CDD cd06174 MFS # EcoGene EG11732 hsrA # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0055085 transmembrane transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0055085 transmembrane transport # InterPro IPR004638 Drug-R_transpt_efflux_EmrB # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # MISCELLANEOUS HSRA_ECOLI Overexpression causes homocysteine accumulation and reverses rspA-mediated suppression of rpoS. # Organism HSRA_ECOLI Escherichia coli (strain K12) # PATRIC 32123007 VBIEscCol129921_3879 # PIR C65179 C65179 # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HSRA_ECOLI Probable transport protein HsrA # RefSeq NP_418210 NC_000913.3 # RefSeq WP_001280852 NZ_LN832404.1 # SIMILARITY Belongs to the major facilitator superfamily. EmrB family. {ECO 0000305}. # SUBCELLULAR LOCATION HSRA_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF103473 SSF103473; 2 # TCDB 2.A.1.3.51 the major facilitator superfamily (mfs) # TIGRFAMs TIGR00711 efflux_EmrB # eggNOG ENOG4105C0R Bacteria # eggNOG ENOG410XNN3 LUCA BLAST swissprot:HSRA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HSRA_ECOLI BioCyc ECOL316407:JW3733-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3733-MONOMER BioCyc EcoCyc:YIEO-MONOMER http://biocyc.org/getid?id=EcoCyc:YIEO-MONOMER DIP DIP-12470N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12470N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1574-6968.2000.tb09048.x http://dx.doi.org/10.1111/j.1574-6968.2000.tb09048.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1683 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1683 EcoGene EG11732 http://www.ecogene.org/geneInfo.php?eg_id=EG11732 EnsemblBacteria AAC76777 http://www.ensemblgenomes.org/id/AAC76777 EnsemblBacteria AAC76777 http://www.ensemblgenomes.org/id/AAC76777 EnsemblBacteria BAE77534 http://www.ensemblgenomes.org/id/BAE77534 EnsemblBacteria BAE77534 http://www.ensemblgenomes.org/id/BAE77534 EnsemblBacteria BAE77534 http://www.ensemblgenomes.org/id/BAE77534 EnsemblBacteria b3754 http://www.ensemblgenomes.org/id/b3754 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 948265 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948265 HOGENOM HOG000193484 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000193484&db=HOGENOM6 InParanoid P31474 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31474 IntAct P31474 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31474* InterPro IPR004638 http://www.ebi.ac.uk/interpro/entry/IPR004638 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Gene ecj:JW3733 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3733 KEGG_Gene eco:b3754 http://www.genome.jp/dbget-bin/www_bget?eco:b3754 MINT MINT-1239630 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1239630 OMA GSLACAM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GSLACAM PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:HSRA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HSRA_ECOLI PSORT-B swissprot:HSRA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HSRA_ECOLI PSORT2 swissprot:HSRA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HSRA_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:HSRA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HSRA_ECOLI PhylomeDB P31474 http://phylomedb.org/?seqid=P31474 ProteinModelPortal P31474 http://www.proteinmodelportal.org/query/uniprot/P31474 PubMed 10754234 http://www.ncbi.nlm.nih.gov/pubmed/10754234 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418210 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418210 RefSeq WP_001280852 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001280852 STRING 511145.b3754 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3754&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.3.51 http://www.tcdb.org/search/result.php?tc=2.A.1.3.51 TIGRFAMs TIGR00711 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00711 UniProtKB HSRA_ECOLI http://www.uniprot.org/uniprot/HSRA_ECOLI UniProtKB-AC P31474 http://www.uniprot.org/uniprot/P31474 charge swissprot:HSRA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HSRA_ECOLI eggNOG ENOG4105C0R http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C0R eggNOG ENOG410XNN3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNN3 epestfind swissprot:HSRA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HSRA_ECOLI garnier swissprot:HSRA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HSRA_ECOLI helixturnhelix swissprot:HSRA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HSRA_ECOLI hmoment swissprot:HSRA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HSRA_ECOLI iep swissprot:HSRA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HSRA_ECOLI inforesidue swissprot:HSRA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HSRA_ECOLI octanol swissprot:HSRA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HSRA_ECOLI pepcoil swissprot:HSRA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HSRA_ECOLI pepdigest swissprot:HSRA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HSRA_ECOLI pepinfo swissprot:HSRA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HSRA_ECOLI pepnet swissprot:HSRA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HSRA_ECOLI pepstats swissprot:HSRA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HSRA_ECOLI pepwheel swissprot:HSRA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HSRA_ECOLI pepwindow swissprot:HSRA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HSRA_ECOLI sigcleave swissprot:HSRA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HSRA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262532 9 # EcoGene EG12624 yiaG # GO_function GO:0043565 sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.260.40 -; 1. # IntAct P0A9V5 6 # InterPro IPR001387 Cro/C1-type_HTH # InterPro IPR010982 Lambda_DNA-bd_dom # KEGG_Brite ko03000 Transcription factors # Organism YIAG_ECOLI Escherichia coli (strain K12) # PATRIC 32122582 VBIEscCol129921_3668 # PIR S47776 S47776 # PROSITE PS50943 HTH_CROC1 # Pfam PF01381 HTH_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIAG_ECOLI Uncharacterized HTH-type transcriptional regulator YiaG # RefSeq NP_418011 NC_000913.3 # RefSeq WP_000455798 NZ_LN832404.1 # SIMILARITY Contains 1 HTH cro/C1-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00257}. # SMART SM00530 HTH_XRE # SUPFAM SSF47413 SSF47413 # eggNOG COG2944 LUCA # eggNOG ENOG4105MVF Bacteria BLAST swissprot:YIAG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIAG_ECOLI BioCyc ECOL316407:JW3524-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3524-MONOMER BioCyc EcoCyc:EG12624-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12624-MONOMER COG COG2944 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2944 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.87.1.283 http://dx.doi.org/10.1073/pnas.87.1.283 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M30139 http://www.ebi.ac.uk/ena/data/view/M30139 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2508 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2508 EcoGene EG12624 http://www.ecogene.org/geneInfo.php?eg_id=EG12624 EnsemblBacteria AAC76579 http://www.ensemblgenomes.org/id/AAC76579 EnsemblBacteria AAC76579 http://www.ensemblgenomes.org/id/AAC76579 EnsemblBacteria BAE77740 http://www.ensemblgenomes.org/id/BAE77740 EnsemblBacteria BAE77740 http://www.ensemblgenomes.org/id/BAE77740 EnsemblBacteria BAE77740 http://www.ensemblgenomes.org/id/BAE77740 EnsemblBacteria b3555 http://www.ensemblgenomes.org/id/b3555 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.260.40 http://www.cathdb.info/version/latest/superfamily/1.10.260.40 GeneID 948071 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948071 HOGENOM HOG000265486 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000265486&db=HOGENOM6 IntAct P0A9V5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9V5* InterPro IPR001387 http://www.ebi.ac.uk/interpro/entry/IPR001387 InterPro IPR010982 http://www.ebi.ac.uk/interpro/entry/IPR010982 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW3524 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3524 KEGG_Gene eco:b3555 http://www.genome.jp/dbget-bin/www_bget?eco:b3555 KEGG_Orthology KO:K07726 http://www.genome.jp/dbget-bin/www_bget?KO:K07726 OMA MAMPEPQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MAMPEPQ PROSITE PS50943 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50943 PSORT swissprot:YIAG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIAG_ECOLI PSORT-B swissprot:YIAG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIAG_ECOLI PSORT2 swissprot:YIAG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIAG_ECOLI Pfam PF01381 http://pfam.xfam.org/family/PF01381 Phobius swissprot:YIAG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIAG_ECOLI ProteinModelPortal P0A9V5 http://www.proteinmodelportal.org/query/uniprot/P0A9V5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2404279 http://www.ncbi.nlm.nih.gov/pubmed/2404279 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418011 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418011 RefSeq WP_000455798 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000455798 SMART SM00530 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00530 STRING 511145.b3555 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3555&targetmode=cogs STRING COG2944 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2944&targetmode=cogs SUPFAM SSF47413 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47413 UniProtKB YIAG_ECOLI http://www.uniprot.org/uniprot/YIAG_ECOLI UniProtKB-AC P0A9V5 http://www.uniprot.org/uniprot/P0A9V5 charge swissprot:YIAG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIAG_ECOLI eggNOG COG2944 http://eggnogapi.embl.de/nog_data/html/tree/COG2944 eggNOG ENOG4105MVF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105MVF epestfind swissprot:YIAG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIAG_ECOLI garnier swissprot:YIAG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIAG_ECOLI helixturnhelix swissprot:YIAG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIAG_ECOLI hmoment swissprot:YIAG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIAG_ECOLI iep swissprot:YIAG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIAG_ECOLI inforesidue swissprot:YIAG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIAG_ECOLI octanol swissprot:YIAG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIAG_ECOLI pepcoil swissprot:YIAG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIAG_ECOLI pepdigest swissprot:YIAG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIAG_ECOLI pepinfo swissprot:YIAG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIAG_ECOLI pepnet swissprot:YIAG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIAG_ECOLI pepstats swissprot:YIAG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIAG_ECOLI pepwheel swissprot:YIAG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIAG_ECOLI pepwindow swissprot:YIAG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIAG_ECOLI sigcleave swissprot:YIAG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIAG_ECOLI ## Database ID URL or Descriptions # BioGrid 4260342 3 # EcoGene EG13514 yoaB # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_process GO:0044010 single-species biofilm formation; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_process GO:0008150 biological_process # Gene3D 3.30.1330.40 -; 1. # InterPro IPR006175 YjgF/YER057c/UK114 # InterPro IPR013813 Endoribo_LPSP/chorism_mut-like # InterPro IPR019897 RidA_CS # Organism YOAB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11803 PTHR11803 # PATRIC 32118935 VBIEscCol129921_1885 # PIR A64942 A64942 # PROSITE PS01094 UPF0076 # Pfam PF01042 Ribonuc_L-PSP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YOAB_ECOLI RutC family protein YoaB # RefSeq NP_416323 NC_000913.3 # RefSeq WP_001295493 NZ_LN832404.1 # SIMILARITY Belongs to the RutC family. {ECO 0000305}. # SUPFAM SSF55298 SSF55298 # eggNOG COG0251 LUCA # eggNOG ENOG4105M4H Bacteria BLAST swissprot:YOAB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YOAB_ECOLI BioCyc ECOL316407:JW5295-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5295-MONOMER BioCyc EcoCyc:G6993-MONOMER http://biocyc.org/getid?id=EcoCyc:G6993-MONOMER DIP DIP-47897N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47897N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3287 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3287 EcoGene EG13514 http://www.ecogene.org/geneInfo.php?eg_id=EG13514 EnsemblBacteria AAC74879 http://www.ensemblgenomes.org/id/AAC74879 EnsemblBacteria AAC74879 http://www.ensemblgenomes.org/id/AAC74879 EnsemblBacteria BAA15618 http://www.ensemblgenomes.org/id/BAA15618 EnsemblBacteria BAA15618 http://www.ensemblgenomes.org/id/BAA15618 EnsemblBacteria BAA15618 http://www.ensemblgenomes.org/id/BAA15618 EnsemblBacteria b1809 http://www.ensemblgenomes.org/id/b1809 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_process GO:0044010 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044010 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.30.1330.40 http://www.cathdb.info/version/latest/superfamily/3.30.1330.40 GeneID 946357 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946357 HOGENOM HOG000267214 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267214&db=HOGENOM6 InParanoid P0AEB7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEB7 InterPro IPR006175 http://www.ebi.ac.uk/interpro/entry/IPR006175 InterPro IPR013813 http://www.ebi.ac.uk/interpro/entry/IPR013813 InterPro IPR019897 http://www.ebi.ac.uk/interpro/entry/IPR019897 KEGG_Gene ecj:JW5295 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5295 KEGG_Gene eco:b1809 http://www.genome.jp/dbget-bin/www_bget?eco:b1809 OMA NEAWDAW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NEAWDAW PANTHER PTHR11803 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11803 PROSITE PS01094 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01094 PSORT swissprot:YOAB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YOAB_ECOLI PSORT-B swissprot:YOAB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YOAB_ECOLI PSORT2 swissprot:YOAB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YOAB_ECOLI Pfam PF01042 http://pfam.xfam.org/family/PF01042 Phobius swissprot:YOAB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YOAB_ECOLI PhylomeDB P0AEB7 http://phylomedb.org/?seqid=P0AEB7 ProteinModelPortal P0AEB7 http://www.proteinmodelportal.org/query/uniprot/P0AEB7 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416323 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416323 RefSeq WP_001295493 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295493 SMR P0AEB7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEB7 STRING 511145.b1809 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1809&targetmode=cogs SUPFAM SSF55298 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55298 UniProtKB YOAB_ECOLI http://www.uniprot.org/uniprot/YOAB_ECOLI UniProtKB-AC P0AEB7 http://www.uniprot.org/uniprot/P0AEB7 charge swissprot:YOAB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YOAB_ECOLI eggNOG COG0251 http://eggnogapi.embl.de/nog_data/html/tree/COG0251 eggNOG ENOG4105M4H http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105M4H epestfind swissprot:YOAB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YOAB_ECOLI garnier swissprot:YOAB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YOAB_ECOLI helixturnhelix swissprot:YOAB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YOAB_ECOLI hmoment swissprot:YOAB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YOAB_ECOLI iep swissprot:YOAB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YOAB_ECOLI inforesidue swissprot:YOAB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YOAB_ECOLI octanol swissprot:YOAB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YOAB_ECOLI pepcoil swissprot:YOAB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YOAB_ECOLI pepdigest swissprot:YOAB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YOAB_ECOLI pepinfo swissprot:YOAB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YOAB_ECOLI pepnet swissprot:YOAB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YOAB_ECOLI pepstats swissprot:YOAB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YOAB_ECOLI pepwheel swissprot:YOAB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YOAB_ECOLI pepwindow swissprot:YOAB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YOAB_ECOLI sigcleave swissprot:YOAB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YOAB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260867 5 # CDD cd06261 TM_PBP2 # EcoGene EG12835 yhdX # FUNCTION YHDX_ECOLI Probably part of the binding-protein-dependent transport system YdhWXYZ for an amino acid; probably responsible for the translocation of the substrate across the membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005215 transporter activity; IEA:InterPro. # GO_process GO:0006865 amino acid transport; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006810 transport # Gene3D 1.10.3720.10 -; 2. # InterPro IPR000515 MetI-like # InterPro IPR010065 AA_ABC_transptr_permease_3TM # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00232 General L-amino acid transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism YHDX_ECOLI Escherichia coli (strain K12) # PATRIC 32121970 VBIEscCol129921_3369 # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHDX_ECOLI Putative amino-acid ABC transporter permease protein YhdX # RefSeq WP_000019655 NZ_LN832404.1 # RefSeq YP_026209 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA58073.1; Type=Frameshift; Positions=358; Evidence={ECO 0000305}; # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION YHDX_ECOLI Cell inner membrane {ECO 0000305}; Multi- pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00441}. # SUPFAM SSF161098 SSF161098; 2 # TCDB 3.A.1.3.26 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR01726 HEQRo_perm_3TM # eggNOG COG4597 LUCA # eggNOG ENOG4105EZ7 Bacteria BLAST swissprot:YHDX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHDX_ECOLI BioCyc ECOL316407:JW5544-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5544-MONOMER BioCyc EcoCyc:YHDX-MONOMER http://biocyc.org/getid?id=EcoCyc:YHDX-MONOMER COG COG4597 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4597 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2684 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2684 EcoGene EG12835 http://www.ecogene.org/geneInfo.php?eg_id=EG12835 EnsemblBacteria AAT48174 http://www.ensemblgenomes.org/id/AAT48174 EnsemblBacteria AAT48174 http://www.ensemblgenomes.org/id/AAT48174 EnsemblBacteria BAE77310 http://www.ensemblgenomes.org/id/BAE77310 EnsemblBacteria BAE77310 http://www.ensemblgenomes.org/id/BAE77310 EnsemblBacteria BAE77310 http://www.ensemblgenomes.org/id/BAE77310 EnsemblBacteria b3269 http://www.ensemblgenomes.org/id/b3269 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_process GO:0006865 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 947765 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947765 HOGENOM HOG000267553 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267553&db=HOGENOM6 InParanoid P45767 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45767 InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 InterPro IPR010065 http://www.ebi.ac.uk/interpro/entry/IPR010065 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5544 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5544 KEGG_Gene eco:b3269 http://www.genome.jp/dbget-bin/www_bget?eco:b3269 KEGG_Orthology KO:K09970 http://www.genome.jp/dbget-bin/www_bget?KO:K09970 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA STIYIET http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=STIYIET PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:YHDX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHDX_ECOLI PSORT-B swissprot:YHDX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHDX_ECOLI PSORT2 swissprot:YHDX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHDX_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Phobius swissprot:YHDX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHDX_ECOLI PhylomeDB P45767 http://phylomedb.org/?seqid=P45767 ProteinModelPortal P45767 http://www.proteinmodelportal.org/query/uniprot/P45767 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000019655 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000019655 RefSeq YP_026209 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026209 SMR P45767 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45767 STRING 511145.b3269 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3269&targetmode=cogs STRING COG4597 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4597&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.3.26 http://www.tcdb.org/search/result.php?tc=3.A.1.3.26 TIGRFAMs TIGR01726 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01726 UniProtKB YHDX_ECOLI http://www.uniprot.org/uniprot/YHDX_ECOLI UniProtKB-AC P45767 http://www.uniprot.org/uniprot/P45767 charge swissprot:YHDX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHDX_ECOLI eggNOG COG4597 http://eggnogapi.embl.de/nog_data/html/tree/COG4597 eggNOG ENOG4105EZ7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EZ7 epestfind swissprot:YHDX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHDX_ECOLI garnier swissprot:YHDX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHDX_ECOLI helixturnhelix swissprot:YHDX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHDX_ECOLI hmoment swissprot:YHDX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHDX_ECOLI iep swissprot:YHDX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHDX_ECOLI inforesidue swissprot:YHDX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHDX_ECOLI octanol swissprot:YHDX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHDX_ECOLI pepcoil swissprot:YHDX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHDX_ECOLI pepdigest swissprot:YHDX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHDX_ECOLI pepinfo swissprot:YHDX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHDX_ECOLI pepnet swissprot:YHDX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHDX_ECOLI pepstats swissprot:YHDX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHDX_ECOLI pepwheel swissprot:YHDX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHDX_ECOLI pepwindow swissprot:YHDX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHDX_ECOLI sigcleave swissprot:YHDX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHDX_ECOLI ## Database ID URL or Descriptions # BioGrid 4259282 23 # EcoGene EG10898 rpoN # FUNCTION RP54_ECOLI Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is responsible for the expression of enzymes involved in arginine catabolism. The open complex (sigma-54 and core RNA polymerase) serves as the receptor for the receipt of the melting signal from the remotely bound activator protein GlnG(NtrC). # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_function GO:0003899 DNA-directed RNA polymerase activity; IEA:UniProtKB-KW. # GO_function GO:0016987 sigma factor activity; IEA:UniProtKB-KW. # GO_process GO:0006352 DNA-templated transcription, initiation; IEA:InterPro. # GO_process GO:0006525 arginine metabolic process; IEA:UniProtKB-KW. # GOslim_function GO:0000988 transcription factor activity, protein binding # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # IntAct P24255 14 # InterPro IPR000394 RNA_pol_sigma_54 # InterPro IPR007046 RNA_pol_sigma_54_core-bd # InterPro IPR007634 RNA_pol_sigma_54_DNA-bd # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko03021 Transcription machinery # KEGG_Pathway ko02020 Two-component system # KEGG_Pathway ko05111 Vibrio cholerae pathogenic cycle # Organism RP54_ECOLI Escherichia coli (strain K12) # PATRIC 32121824 VBIEscCol129921_3296 # PDB 2MT3 NMR; -; A=414-477 # PIR I57054 A35695 # PIRSF PIRSF000774 RpoN # PRINTS PR00045 SIGMA54FCT # PROSITE PS00717 SIGMA54_1 # PROSITE PS00718 SIGMA54_2 # PROSITE PS50044 SIGMA54_3 # Pfam PF00309 Sigma54_AID # Pfam PF04552 Sigma54_DBD # Pfam PF04963 Sigma54_CBD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RP54_ECOLI RNA polymerase sigma-54 factor # RefSeq NP_417669 NC_000913.3 # RefSeq WP_000809057 NZ_LN832404.1 # SIMILARITY Belongs to the sigma-54 factor family. {ECO 0000305}. # TIGRFAMs TIGR02395 rpoN_sigma # eggNOG COG1508 LUCA # eggNOG ENOG4105DTW Bacteria BLAST swissprot:RP54_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RP54_ECOLI BioCyc ECOL316407:JW3169-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3169-MONOMER BioCyc EcoCyc:RPON-MONOMER http://biocyc.org/getid?id=EcoCyc:RPON-MONOMER BioCyc MetaCyc:RPON-MONOMER http://biocyc.org/getid?id=MetaCyc:RPON-MONOMER COG COG1508 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1508 DIP DIP-10776N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10776N DOI 10.1016/0092-8674(90)90269-K http://dx.doi.org/10.1016/0092-8674(90)90269-K DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.270.9.4822 http://dx.doi.org/10.1074/jbc.270.9.4822 DOI 10.1099/13500872-140-5-1035 http://dx.doi.org/10.1099/13500872-140-5-1035 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D12938 http://www.ebi.ac.uk/ena/data/view/D12938 EMBL M57612 http://www.ebi.ac.uk/ena/data/view/M57612 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U12684 http://www.ebi.ac.uk/ena/data/view/U12684 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL Z27094 http://www.ebi.ac.uk/ena/data/view/Z27094 EchoBASE EB0891 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0891 EcoGene EG10898 http://www.ecogene.org/geneInfo.php?eg_id=EG10898 EnsemblBacteria AAC76234 http://www.ensemblgenomes.org/id/AAC76234 EnsemblBacteria AAC76234 http://www.ensemblgenomes.org/id/AAC76234 EnsemblBacteria BAE77246 http://www.ensemblgenomes.org/id/BAE77246 EnsemblBacteria BAE77246 http://www.ensemblgenomes.org/id/BAE77246 EnsemblBacteria BAE77246 http://www.ensemblgenomes.org/id/BAE77246 EnsemblBacteria b3202 http://www.ensemblgenomes.org/id/b3202 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0003899 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003899 GO_function GO:0016987 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016987 GO_process GO:0006352 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006352 GO_process GO:0006525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006525 GOslim_function GO:0000988 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000988 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 947714 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947714 HOGENOM HOG000071905 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000071905&db=HOGENOM6 InParanoid P24255 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P24255 IntAct P24255 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P24255* InterPro IPR000394 http://www.ebi.ac.uk/interpro/entry/IPR000394 InterPro IPR007046 http://www.ebi.ac.uk/interpro/entry/IPR007046 InterPro IPR007634 http://www.ebi.ac.uk/interpro/entry/IPR007634 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko03021 http://www.genome.jp/dbget-bin/www_bget?ko03021 KEGG_Gene ecj:JW3169 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3169 KEGG_Gene eco:b3202 http://www.genome.jp/dbget-bin/www_bget?eco:b3202 KEGG_Orthology KO:K03092 http://www.genome.jp/dbget-bin/www_bget?KO:K03092 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 KEGG_Pathway ko05111 http://www.genome.jp/kegg-bin/show_pathway?ko05111 MINT MINT-1224654 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1224654 OMA TQKFMHT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TQKFMHT PDB 2MT3 http://www.ebi.ac.uk/pdbe-srv/view/entry/2MT3 PDBsum 2MT3 http://www.ebi.ac.uk/pdbsum/2MT3 PRINTS PR00045 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00045 PROSITE PS00717 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00717 PROSITE PS00718 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00718 PROSITE PS50044 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50044 PSORT swissprot:RP54_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RP54_ECOLI PSORT-B swissprot:RP54_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RP54_ECOLI PSORT2 swissprot:RP54_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RP54_ECOLI Pfam PF00309 http://pfam.xfam.org/family/PF00309 Pfam PF04552 http://pfam.xfam.org/family/PF04552 Pfam PF04963 http://pfam.xfam.org/family/PF04963 Phobius swissprot:RP54_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RP54_ECOLI PhylomeDB P24255 http://phylomedb.org/?seqid=P24255 ProteinModelPortal P24255 http://www.proteinmodelportal.org/query/uniprot/P24255 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2203540 http://www.ncbi.nlm.nih.gov/pubmed/2203540 PubMed 7876255 http://www.ncbi.nlm.nih.gov/pubmed/7876255 PubMed 8025669 http://www.ncbi.nlm.nih.gov/pubmed/8025669 PubMed 8444818 http://www.ncbi.nlm.nih.gov/pubmed/8444818 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417669 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417669 RefSeq WP_000809057 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000809057 SMR P24255 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P24255 STRING 511145.b3202 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3202&targetmode=cogs STRING COG1508 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1508&targetmode=cogs TIGRFAMs TIGR02395 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02395 UniProtKB RP54_ECOLI http://www.uniprot.org/uniprot/RP54_ECOLI UniProtKB-AC P24255 http://www.uniprot.org/uniprot/P24255 charge swissprot:RP54_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RP54_ECOLI eggNOG COG1508 http://eggnogapi.embl.de/nog_data/html/tree/COG1508 eggNOG ENOG4105DTW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DTW epestfind swissprot:RP54_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RP54_ECOLI garnier swissprot:RP54_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RP54_ECOLI helixturnhelix swissprot:RP54_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RP54_ECOLI hmoment swissprot:RP54_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RP54_ECOLI iep swissprot:RP54_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RP54_ECOLI inforesidue swissprot:RP54_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RP54_ECOLI octanol swissprot:RP54_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RP54_ECOLI pepcoil swissprot:RP54_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RP54_ECOLI pepdigest swissprot:RP54_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RP54_ECOLI pepinfo swissprot:RP54_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RP54_ECOLI pepnet swissprot:RP54_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RP54_ECOLI pepstats swissprot:RP54_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RP54_ECOLI pepwheel swissprot:RP54_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RP54_ECOLI pepwindow swissprot:RP54_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RP54_ECOLI sigcleave swissprot:RP54_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RP54_ECOLI ## Database ID URL or Descriptions # AltName EPTB_ECOLI Phosphoethanolamine transferase EptB # BioGrid 4262537 2 # CATALYTIC ACTIVITY Diacylphosphatidylethanolamine + alpha-D-Kdo- (2->4)-alpha-D-Kdo-(2->6)-lipid A = diacyglycerol + 7-O-(2- aminoethoxy(hydroxy)phosphoryl)-alpha-D-Kdo-(2->4)-alpha-D-Kdo- (2->6)-lipid A. {ECO:0000269|PubMed 15795227}. # CATALYTIC ACTIVITY Diacylphosphatidylethanolamine + alpha-D-Kdo- (2->4)-alpha-D-Kdo-(2->6)-lipid IV(A) = diacyglycerol + 7-O-(2- aminoethoxy(hydroxy)phosphoryl)-alpha-D-Kdo-(2->4)-alpha-D-Kdo- (2->6)-lipid IV(A). {ECO:0000269|PubMed 15795227}. # COFACTOR EPTB_ECOLI Name=Ca(2+); Xref=ChEBI CHEBI 29108; Evidence={ECO 0000269|PubMed 15795227}; # ENZYME REGULATION Inhibited by calcium concentrations higher than 1 mM. {ECO:0000269|PubMed 15795227}. # EcoGene EG12267 eptB # FUNCTION EPTB_ECOLI Catalyzes the addition of a phosphoethanolamine (pEtN) moiety to the outer 3-deoxy-D-manno-octulosonic acid (Kdo) residue of a Kdo(2)-lipid A. Phosphatidylethanolamines with one unsaturated acyl group functions as pEtN donors and the reaction releases diacylglycerol. {ECO 0000269|PubMed 15795227}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function EPTB_ECOLI GO 0043838 phosphatidylethanolamine Kdo2-lipid A phosphoethanolamine transferase activity; IDA EcoCyc. # GO_function GO:0008484 sulfuric ester hydrolase activity; IEA:InterPro. # GO_process GO:0009244 lipopolysaccharide core region biosynthetic process; IBA:GO_Central. # GO_process GO:0009245 lipid A biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.720.10 -; 1. # IntAct P37661 5 # InterPro IPR000917 Sulfatase_N # InterPro IPR012549 DUF1705 # InterPro IPR017849 Alkaline_Pase-like_a/b/a # InterPro IPR017850 Alkaline_phosphatase_core # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # Organism EPTB_ECOLI Escherichia coli (strain K12) # PATRIC 32122564 VBIEscCol129921_3659 # PIR D65153 D65153 # Pfam PF00884 Sulfatase # Pfam PF08019 DUF1705 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EPTB_ECOLI Kdo(2)-lipid A phosphoethanolamine 7''-transferase # RefSeq NP_418002 NC_000913.3 # RefSeq WP_001269197 NZ_LN832404.1 # SIMILARITY Belongs to the phosphoethanolamine transferase family. EptB subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION EPTB_ECOLI Cell inner membrane {ECO 0000269|PubMed 15795227}; Multi-pass membrane protein {ECO 0000269|PubMed 15795227}. # SUPFAM SSF53649 SSF53649 # eggNOG COG2194 LUCA # eggNOG ENOG4105DIJ Bacteria BLAST swissprot:EPTB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EPTB_ECOLI BioCyc ECOL316407:JW5660-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5660-MONOMER BioCyc EcoCyc:EG12267-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12267-MONOMER BioCyc MetaCyc:EG12267-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12267-MONOMER COG COG2194 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2194 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M500964200 http://dx.doi.org/10.1074/jbc.M500964200 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.8.42 {ECO:0000269|PubMed:15795227} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.8.42 {ECO:0000269|PubMed:15795227} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.8.42 {ECO:0000269|PubMed:15795227} http://enzyme.expasy.org/EC/2.7.8.42 {ECO:0000269|PubMed:15795227} EchoBASE EB2176 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2176 EcoGene EG12267 http://www.ecogene.org/geneInfo.php?eg_id=EG12267 EnsemblBacteria AAC76570 http://www.ensemblgenomes.org/id/AAC76570 EnsemblBacteria AAC76570 http://www.ensemblgenomes.org/id/AAC76570 EnsemblBacteria BAE77749 http://www.ensemblgenomes.org/id/BAE77749 EnsemblBacteria BAE77749 http://www.ensemblgenomes.org/id/BAE77749 EnsemblBacteria BAE77749 http://www.ensemblgenomes.org/id/BAE77749 EnsemblBacteria b3546 http://www.ensemblgenomes.org/id/b3546 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008484 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008484 GO_function GO:0043838 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043838 GO_process GO:0009244 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009244 GO_process GO:0009245 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009245 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.720.10 http://www.cathdb.info/version/latest/superfamily/3.40.720.10 GeneID 948068 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948068 HOGENOM HOG000125991 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125991&db=HOGENOM6 InParanoid P37661 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37661 IntAct P37661 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37661* IntEnz 2.7.8.42 {ECO:0000269|PubMed:15795227} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.8.42 {ECO:0000269|PubMed:15795227} InterPro IPR000917 http://www.ebi.ac.uk/interpro/entry/IPR000917 InterPro IPR012549 http://www.ebi.ac.uk/interpro/entry/IPR012549 InterPro IPR017849 http://www.ebi.ac.uk/interpro/entry/IPR017849 InterPro IPR017850 http://www.ebi.ac.uk/interpro/entry/IPR017850 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Gene ecj:JW5660 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5660 KEGG_Gene eco:b3546 http://www.genome.jp/dbget-bin/www_bget?eco:b3546 KEGG_Orthology KO:K12975 http://www.genome.jp/dbget-bin/www_bget?KO:K12975 OMA FAMQSEV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FAMQSEV PSORT swissprot:EPTB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EPTB_ECOLI PSORT-B swissprot:EPTB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EPTB_ECOLI PSORT2 swissprot:EPTB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EPTB_ECOLI Pfam PF00884 http://pfam.xfam.org/family/PF00884 Pfam PF08019 http://pfam.xfam.org/family/PF08019 Phobius swissprot:EPTB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EPTB_ECOLI PhylomeDB P37661 http://phylomedb.org/?seqid=P37661 ProteinModelPortal P37661 http://www.proteinmodelportal.org/query/uniprot/P37661 PubMed 15795227 http://www.ncbi.nlm.nih.gov/pubmed/15795227 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_418002 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418002 RefSeq WP_001269197 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001269197 SMR P37661 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37661 STRING 511145.b3546 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3546&targetmode=cogs STRING COG2194 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2194&targetmode=cogs SUPFAM SSF53649 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53649 UniProtKB EPTB_ECOLI http://www.uniprot.org/uniprot/EPTB_ECOLI UniProtKB-AC P37661 http://www.uniprot.org/uniprot/P37661 charge swissprot:EPTB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EPTB_ECOLI eggNOG COG2194 http://eggnogapi.embl.de/nog_data/html/tree/COG2194 eggNOG ENOG4105DIJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DIJ epestfind swissprot:EPTB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EPTB_ECOLI garnier swissprot:EPTB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EPTB_ECOLI helixturnhelix swissprot:EPTB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EPTB_ECOLI hmoment swissprot:EPTB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EPTB_ECOLI iep swissprot:EPTB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EPTB_ECOLI inforesidue swissprot:EPTB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EPTB_ECOLI octanol swissprot:EPTB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EPTB_ECOLI pepcoil swissprot:EPTB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EPTB_ECOLI pepdigest swissprot:EPTB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EPTB_ECOLI pepinfo swissprot:EPTB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EPTB_ECOLI pepnet swissprot:EPTB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EPTB_ECOLI pepstats swissprot:EPTB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EPTB_ECOLI pepwheel swissprot:EPTB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EPTB_ECOLI pepwindow swissprot:EPTB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EPTB_ECOLI sigcleave swissprot:EPTB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EPTB_ECOLI ## Database ID URL or Descriptions # BRENDA 2.8.1.10 2026 # BioGrid 4262656 16 # CATALYTIC ACTIVITY THIG_ECOLI 1-deoxy-D-xylulose 5-phosphate + 2- iminoacetate + thiocarboxy-[sulfur-carrier protein ThiS] = 2- ((2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate + [sulfur-carrier protein ThiS] + 2 H(2)O. # CDD cd04728 ThiG # EcoGene EG11589 thiG # FUNCTION THIG_ECOLI Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. {ECO 0000269|PubMed 12650933}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0016783 sulfurtransferase activity; IEA:UniProtKB-HAMAP. # GO_process GO:0009228 thiamine biosynthetic process; IMP:EcoCyc. # GO_process GO:0009229 thiamine diphosphate biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.20.20.70 -; 1. # HAMAP MF_00443 ThiG # INTERACTION THIG_ECOLI P30140 thiH; NbExp=2; IntAct=EBI-547059, EBI-1125553; # IntAct P30139 10 # InterPro IPR008867 ThiG # InterPro IPR013785 Aldolase_TIM # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko00730 Thiamine metabolism # MASS SPECTROMETRY Mass=26893.3; Method=Electrospray; Range=1-256; Evidence={ECO:0000269|PubMed 12650933}; # MASS SPECTROMETRY Mass=26896.5; Method=Electrospray; Range=1-256; Evidence={ECO:0000269|PubMed 10082377}; # Organism THIG_ECOLI Escherichia coli (strain K12) # PATHWAY THIG_ECOLI Cofactor biosynthesis; thiamine diphosphate biosynthesis. # PATRIC 32123503 VBIEscCol129921_4104 # PIR B65206 B65206 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName THIG_ECOLI Thiazole synthase # RefSeq NP_418418 NC_000913.3 # RefSeq WP_000944104 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAC43089.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ThiG family. {ECO 0000305}. # SUBCELLULAR LOCATION THIG_ECOLI Cytoplasm. # SUBUNIT Homotetramer. Forms heterodimers with either ThiH or ThiS. {ECO:0000269|PubMed 12650933}. # eggNOG COG2022 LUCA # eggNOG ENOG4105CA8 Bacteria BLAST swissprot:THIG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:THIG_ECOLI BioCyc ECOL316407:JW5549-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5549-MONOMER BioCyc EcoCyc:THIG-MONOMER http://biocyc.org/getid?id=EcoCyc:THIG-MONOMER BioCyc MetaCyc:THIG-MONOMER http://biocyc.org/getid?id=MetaCyc:THIG-MONOMER COG COG2022 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2022 DIP DIP-6868N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-6868N DOI 10.1002/pro.5560070815 http://dx.doi.org/10.1002/pro.5560070815 DOI 10.1016/S0014-5793(03)00204-7 http://dx.doi.org/10.1016/S0014-5793(03)00204-7 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.8.1.10 http://www.genome.jp/dbget-bin/www_bget?EC:2.8.1.10 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M88701 http://www.ebi.ac.uk/ena/data/view/M88701 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.8.1.10 http://enzyme.expasy.org/EC/2.8.1.10 EchoBASE EB1547 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1547 EcoGene EG11589 http://www.ecogene.org/geneInfo.php?eg_id=EG11589 EnsemblBacteria AAC76965 http://www.ensemblgenomes.org/id/AAC76965 EnsemblBacteria AAC76965 http://www.ensemblgenomes.org/id/AAC76965 EnsemblBacteria BAE77329 http://www.ensemblgenomes.org/id/BAE77329 EnsemblBacteria BAE77329 http://www.ensemblgenomes.org/id/BAE77329 EnsemblBacteria BAE77329 http://www.ensemblgenomes.org/id/BAE77329 EnsemblBacteria b3991 http://www.ensemblgenomes.org/id/b3991 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0016783 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016783 GO_process GO:0009228 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009228 GO_process GO:0009229 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009229 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 948493 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948493 HAMAP MF_00443 http://hamap.expasy.org/unirule/MF_00443 HOGENOM HOG000248049 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000248049&db=HOGENOM6 InParanoid P30139 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30139 IntAct P30139 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P30139* IntEnz 2.8.1.10 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.8.1.10 InterPro IPR008867 http://www.ebi.ac.uk/interpro/entry/IPR008867 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW5549 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5549 KEGG_Gene eco:b3991 http://www.genome.jp/dbget-bin/www_bget?eco:b3991 KEGG_Orthology KO:K03149 http://www.genome.jp/dbget-bin/www_bget?KO:K03149 KEGG_Pathway ko00730 http://www.genome.jp/kegg-bin/show_pathway?ko00730 KEGG_Reaction rn:R07465 http://www.genome.jp/dbget-bin/www_bget?rn:R07465 MINT MINT-1289283 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1289283 OMA AQYPSPA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AQYPSPA PSORT swissprot:THIG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:THIG_ECOLI PSORT-B swissprot:THIG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:THIG_ECOLI PSORT2 swissprot:THIG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:THIG_ECOLI Phobius swissprot:THIG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:THIG_ECOLI PhylomeDB P30139 http://phylomedb.org/?seqid=P30139 ProteinModelPortal P30139 http://www.proteinmodelportal.org/query/uniprot/P30139 PubMed 10082377 http://www.ncbi.nlm.nih.gov/pubmed/10082377 PubMed 12650933 http://www.ncbi.nlm.nih.gov/pubmed/12650933 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 8432721 http://www.ncbi.nlm.nih.gov/pubmed/8432721 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418418 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418418 RefSeq WP_000944104 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000944104 SMR P30139 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P30139 STRING 511145.b3991 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3991&targetmode=cogs STRING COG2022 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2022&targetmode=cogs UniProtKB THIG_ECOLI http://www.uniprot.org/uniprot/THIG_ECOLI UniProtKB-AC P30139 http://www.uniprot.org/uniprot/P30139 charge swissprot:THIG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:THIG_ECOLI eggNOG COG2022 http://eggnogapi.embl.de/nog_data/html/tree/COG2022 eggNOG ENOG4105CA8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CA8 epestfind swissprot:THIG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:THIG_ECOLI garnier swissprot:THIG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:THIG_ECOLI helixturnhelix swissprot:THIG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:THIG_ECOLI hmoment swissprot:THIG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:THIG_ECOLI iep swissprot:THIG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:THIG_ECOLI inforesidue swissprot:THIG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:THIG_ECOLI octanol swissprot:THIG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:THIG_ECOLI pepcoil swissprot:THIG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:THIG_ECOLI pepdigest swissprot:THIG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:THIG_ECOLI pepinfo swissprot:THIG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:THIG_ECOLI pepnet swissprot:THIG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:THIG_ECOLI pepstats swissprot:THIG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:THIG_ECOLI pepwheel swissprot:THIG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:THIG_ECOLI pepwindow swissprot:THIG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:THIG_ECOLI sigcleave swissprot:THIG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:THIG_ECOLI ## Database ID URL or Descriptions # BioGrid 4261636 18 # EcoGene EG11785 yfiE # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; ISS:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # IntAct P33634 3 # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR005119 LysR_subst-bd # InterPro IPR011991 WHTH_DNA-bd_dom # Organism YFIE_ECOLI Escherichia coli (strain K12) # PATRIC 32120555 VBIEscCol129921_2680 # PIR H65035 H65035 # PROSITE PS50931 HTH_LYSR # Pfam PF00126 HTH_1 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFIE_ECOLI Uncharacterized HTH-type transcriptional regulator YfiE # RefSeq NP_417072 NC_000913.3 # RefSeq WP_001300638 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lysR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00253}. # SUPFAM SSF46785 SSF46785 # eggNOG ENOG41090KR Bacteria # eggNOG ENOG4111QDM LUCA BLAST swissprot:YFIE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFIE_ECOLI BioCyc ECOL316407:JW2561-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2561-MONOMER BioCyc EcoCyc:EG11785-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11785-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D13169 http://www.ebi.ac.uk/ena/data/view/D13169 EMBL D64044 http://www.ebi.ac.uk/ena/data/view/D64044 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1733 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1733 EcoGene EG11785 http://www.ecogene.org/geneInfo.php?eg_id=EG11785 EnsemblBacteria AAC75630 http://www.ensemblgenomes.org/id/AAC75630 EnsemblBacteria AAC75630 http://www.ensemblgenomes.org/id/AAC75630 EnsemblBacteria BAA20920 http://www.ensemblgenomes.org/id/BAA20920 EnsemblBacteria BAA20920 http://www.ensemblgenomes.org/id/BAA20920 EnsemblBacteria BAA20920 http://www.ensemblgenomes.org/id/BAA20920 EnsemblBacteria b2577 http://www.ensemblgenomes.org/id/b2577 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 947064 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947064 HOGENOM HOG000233521 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000233521&db=HOGENOM6 InParanoid P33634 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33634 IntAct P33634 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33634* InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW2561 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2561 KEGG_Gene eco:b2577 http://www.genome.jp/dbget-bin/www_bget?eco:b2577 OMA MRVFMQC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MRVFMQC PROSITE PS50931 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50931 PSORT swissprot:YFIE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFIE_ECOLI PSORT-B swissprot:YFIE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFIE_ECOLI PSORT2 swissprot:YFIE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFIE_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:YFIE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFIE_ECOLI PhylomeDB P33634 http://phylomedb.org/?seqid=P33634 ProteinModelPortal P33634 http://www.proteinmodelportal.org/query/uniprot/P33634 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417072 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417072 RefSeq WP_001300638 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300638 SMR P33634 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33634 STRING 511145.b2577 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2577&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB YFIE_ECOLI http://www.uniprot.org/uniprot/YFIE_ECOLI UniProtKB-AC P33634 http://www.uniprot.org/uniprot/P33634 charge swissprot:YFIE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFIE_ECOLI eggNOG ENOG41090KR http://eggnogapi.embl.de/nog_data/html/tree/ENOG41090KR eggNOG ENOG4111QDM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111QDM epestfind swissprot:YFIE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFIE_ECOLI garnier swissprot:YFIE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFIE_ECOLI helixturnhelix swissprot:YFIE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFIE_ECOLI hmoment swissprot:YFIE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFIE_ECOLI iep swissprot:YFIE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFIE_ECOLI inforesidue swissprot:YFIE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFIE_ECOLI octanol swissprot:YFIE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFIE_ECOLI pepcoil swissprot:YFIE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFIE_ECOLI pepdigest swissprot:YFIE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFIE_ECOLI pepinfo swissprot:YFIE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFIE_ECOLI pepnet swissprot:YFIE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFIE_ECOLI pepstats swissprot:YFIE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFIE_ECOLI pepwheel swissprot:YFIE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFIE_ECOLI pepwindow swissprot:YFIE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFIE_ECOLI sigcleave swissprot:YFIE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFIE_ECOLI ## Database ID URL or Descriptions # AltName RAVA_ECOLI Regulatory ATPase variant A # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=790 uM for ATP (at pH 7.5); Note=RavA also has GTPase activity.; pH dependence Optimum pH is 7.5.; # BioGrid 4262601 623 # ENZYME REGULATION RAVA_ECOLI The complex formed with CadA represents a possible means of regulating RavA activity in response to acid stress conditions. This interaction results in an increase in RavA ATPase activity. # EcoGene EG11731 ravA # FUNCTION RAVA_ECOLI Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone. # GO_component GO:0005737 cytoplasm; IDA:EcoCyc. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances; IEA:InterPro. # GO_function GO:0016887 ATPase activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IPI:IntAct. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.300 -; 1. # HAMAP MF_01625 ATPase_RavA # INDUCTION RAVA_ECOLI Expression is sigma S-dependent. # INTERACTION RAVA_ECOLI Self; NbExp=4; IntAct=EBI-561223, EBI-561223; P0A9H3 cadA; NbExp=7; IntAct=EBI-561223, EBI-545922; # IntAct P31473 21 # InterPro IPR003593 AAA+_ATPase # InterPro IPR011704 ATPase_dyneun-rel_AAA # InterPro IPR022547 ATPase_RavA_C # InterPro IPR023671 ATPase_RavA # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko01000 Enzymes # Organism RAVA_ECOLI Escherichia coli (strain K12) # PATRIC 32122991 VBIEscCol129921_3871 # PDB 3NBX X-ray; 2.91 A; X=1-498 # PDB 4UPB EM; 11.00 A; C/D/E=1-498 # PDB 4UPF EM; 7.50 A; D=329-440 # PDB 5FL2 EM; 6.20 A; K=332-437 # PIR C65178 C65178 # Pfam PF07728 AAA_5 # Pfam PF12592 DUF3763 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RAVA_ECOLI ATPase RavA # RefSeq NP_418202 NC_000913.3 # RefSeq WP_001299914 NZ_LN832404.1 # SIMILARITY Belongs to the RavA family. {ECO 0000305}. # SMART SM00382 AAA # SUBCELLULAR LOCATION RAVA_ECOLI Cytoplasm. # SUBUNIT Hexameric oligomer. Interactions of five RavA oligomers with two CadA decamers. Possible formation of a ternary complex RavA-ViaA-CadA. {ECO:0000269|PubMed 16301313}. # SUPFAM SSF52540 SSF52540 # eggNOG COG0714 LUCA # eggNOG ENOG4107R4Q Bacteria BLAST swissprot:RAVA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RAVA_ECOLI BioCyc ECOL316407:JW3725-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3725-MONOMER BioCyc EcoCyc:EG11731-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11731-MONOMER BioCyc MetaCyc:EG11731-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11731-MONOMER COG COG0714 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0714 DIP DIP-12469N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12469N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M511172200 http://dx.doi.org/10.1074/jbc.M511172200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.3.- http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.6.3.- http://enzyme.expasy.org/EC/3.6.3.- EchoBASE EB1682 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1682 EcoGene EG11731 http://www.ecogene.org/geneInfo.php?eg_id=EG11731 EnsemblBacteria AAC76769 http://www.ensemblgenomes.org/id/AAC76769 EnsemblBacteria AAC76769 http://www.ensemblgenomes.org/id/AAC76769 EnsemblBacteria BAE77542 http://www.ensemblgenomes.org/id/BAE77542 EnsemblBacteria BAE77542 http://www.ensemblgenomes.org/id/BAE77542 EnsemblBacteria BAE77542 http://www.ensemblgenomes.org/id/BAE77542 EnsemblBacteria b3746 http://www.ensemblgenomes.org/id/b3746 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016820 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016820 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948256 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948256 HAMAP MF_01625 http://hamap.expasy.org/unirule/MF_01625 HOGENOM HOG000272029 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000272029&db=HOGENOM6 InParanoid P31473 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31473 IntAct P31473 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31473* IntEnz 3.6.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR011704 http://www.ebi.ac.uk/interpro/entry/IPR011704 InterPro IPR022547 http://www.ebi.ac.uk/interpro/entry/IPR022547 InterPro IPR023671 http://www.ebi.ac.uk/interpro/entry/IPR023671 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3725 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3725 KEGG_Gene eco:b3746 http://www.genome.jp/dbget-bin/www_bget?eco:b3746 KEGG_Orthology KO:K03924 http://www.genome.jp/dbget-bin/www_bget?KO:K03924 MINT MINT-1242859 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1242859 OMA RRFRNGN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RRFRNGN PDB 3NBX http://www.ebi.ac.uk/pdbe-srv/view/entry/3NBX PDB 4UPB http://www.ebi.ac.uk/pdbe-srv/view/entry/4UPB PDB 4UPF http://www.ebi.ac.uk/pdbe-srv/view/entry/4UPF PDB 5FL2 http://www.ebi.ac.uk/pdbe-srv/view/entry/5FL2 PDBsum 3NBX http://www.ebi.ac.uk/pdbsum/3NBX PDBsum 4UPB http://www.ebi.ac.uk/pdbsum/4UPB PDBsum 4UPF http://www.ebi.ac.uk/pdbsum/4UPF PDBsum 5FL2 http://www.ebi.ac.uk/pdbsum/5FL2 PSORT swissprot:RAVA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RAVA_ECOLI PSORT-B swissprot:RAVA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RAVA_ECOLI PSORT2 swissprot:RAVA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RAVA_ECOLI Pfam PF07728 http://pfam.xfam.org/family/PF07728 Pfam PF12592 http://pfam.xfam.org/family/PF12592 Phobius swissprot:RAVA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RAVA_ECOLI PhylomeDB P31473 http://phylomedb.org/?seqid=P31473 ProteinModelPortal P31473 http://www.proteinmodelportal.org/query/uniprot/P31473 PubMed 16301313 http://www.ncbi.nlm.nih.gov/pubmed/16301313 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418202 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418202 RefSeq WP_001299914 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001299914 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P31473 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31473 STRING 511145.b3746 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3746&targetmode=cogs STRING COG0714 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0714&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB RAVA_ECOLI http://www.uniprot.org/uniprot/RAVA_ECOLI UniProtKB-AC P31473 http://www.uniprot.org/uniprot/P31473 charge swissprot:RAVA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RAVA_ECOLI eggNOG COG0714 http://eggnogapi.embl.de/nog_data/html/tree/COG0714 eggNOG ENOG4107R4Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107R4Q epestfind swissprot:RAVA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RAVA_ECOLI garnier swissprot:RAVA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RAVA_ECOLI helixturnhelix swissprot:RAVA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RAVA_ECOLI hmoment swissprot:RAVA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RAVA_ECOLI iep swissprot:RAVA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RAVA_ECOLI inforesidue swissprot:RAVA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RAVA_ECOLI octanol swissprot:RAVA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RAVA_ECOLI pepcoil swissprot:RAVA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RAVA_ECOLI pepdigest swissprot:RAVA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RAVA_ECOLI pepinfo swissprot:RAVA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RAVA_ECOLI pepnet swissprot:RAVA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RAVA_ECOLI pepstats swissprot:RAVA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RAVA_ECOLI pepwheel swissprot:RAVA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RAVA_ECOLI pepwindow swissprot:RAVA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RAVA_ECOLI sigcleave swissprot:RAVA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RAVA_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES PHNM_ECOLI Kinetic parameters KM=56 uM for alpha-D-ribose 1-methylphosphonate 5-triphosphate {ECO 0000269|PubMed 22089136}; KM=98 uM for D-ribose-5-triphosphate {ECO 0000269|PubMed 22089136}; KM=200 uM for D-ribose-5-diphosphate {ECO 0000269|PubMed 22089136}; # BioGrid 4262021 7 # CATALYTIC ACTIVITY Alpha-D-ribose 1-methylphosphonate 5- triphosphate + H(2)O = alpha-D-ribose 1-methylphosphonate 5- phosphate + diphosphate. {ECO:0000269|PubMed 22089136}. # CDD cd01306 PhnM # EcoGene EG10722 phnM # FUNCTION PHNM_ECOLI Catalyzes the hydrolysis of alpha-D-ribose 1- methylphosphonate triphosphate (RPnTP) to form alpha-D-ribose 1- methylphosphonate phosphate (PRPn) and diphosphate. {ECO 0000269|PubMed 22089136}. # GO_function GO:0004000 adenosine deaminase activity; IBA:GO_Central. # GO_function GO:0050270 S-adenosylhomocysteine deaminase activity; IBA:GO_Central. # GO_process GO:0019700 organic phosphonate catabolic process; IMP:EcoCyc. # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_process GO:0009056 catabolic process # Gene3D 2.30.40.10 -; 1. # InterPro IPR011059 Metal-dep_hydrolase_composite # InterPro IPR012696 PhnM # InterPro IPR013108 Amidohydro_3 # InterPro IPR032466 Metal_Hydrolase # MISCELLANEOUS PHNM_ECOLI The sequence shown is that of strain K12. # Organism PHNM_ECOLI Escherichia coli (strain K12) # PATRIC 32123749 VBIEscCol129921_4223 # PIR S56323 S56323 # PIRSF PIRSF038971 PhnM # Pfam PF07969 Amidohydro_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PHNM_ECOLI Alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase # RefSeq NP_418519 NC_000913.3 # RefSeq WP_000586325 NZ_LN832404.1 # SUPFAM SSF51338 SSF51338; 2 # SUPFAM SSF51556 SSF51556 # TIGRFAMs TIGR02318 phosphono_phnM # eggNOG COG3454 LUCA # eggNOG ENOG4105FD8 Bacteria BLAST swissprot:PHNM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PHNM_ECOLI BioCyc ECOL316407:JW4056-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4056-MONOMER BioCyc EcoCyc:EG10722-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10722-MONOMER BioCyc MetaCyc:EG10722-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10722-MONOMER COG COG3454 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3454 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature10622 http://dx.doi.org/10.1038/nature10622 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.1.63 http://www.genome.jp/dbget-bin/www_bget?EC:3.6.1.63 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D90227 http://www.ebi.ac.uk/ena/data/view/D90227 EMBL J05260 http://www.ebi.ac.uk/ena/data/view/J05260 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 3.6.1.63 http://enzyme.expasy.org/EC/3.6.1.63 EchoBASE EB0716 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0716 EcoGene EG10722 http://www.ecogene.org/geneInfo.php?eg_id=EG10722 EnsemblBacteria AAC77056 http://www.ensemblgenomes.org/id/AAC77056 EnsemblBacteria AAC77056 http://www.ensemblgenomes.org/id/AAC77056 EnsemblBacteria BAE78098 http://www.ensemblgenomes.org/id/BAE78098 EnsemblBacteria BAE78098 http://www.ensemblgenomes.org/id/BAE78098 EnsemblBacteria BAE78098 http://www.ensemblgenomes.org/id/BAE78098 EnsemblBacteria b4095 http://www.ensemblgenomes.org/id/b4095 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004000 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004000 GO_function GO:0050270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050270 GO_process GO:0019700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019700 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 2.30.40.10 http://www.cathdb.info/version/latest/superfamily/2.30.40.10 GeneID 948613 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948613 HOGENOM HOG000126996 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126996&db=HOGENOM6 InParanoid P16689 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P16689 IntEnz 3.6.1.63 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.1.63 InterPro IPR011059 http://www.ebi.ac.uk/interpro/entry/IPR011059 InterPro IPR012696 http://www.ebi.ac.uk/interpro/entry/IPR012696 InterPro IPR013108 http://www.ebi.ac.uk/interpro/entry/IPR013108 InterPro IPR032466 http://www.ebi.ac.uk/interpro/entry/IPR032466 KEGG_Gene ecj:JW4056 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4056 KEGG_Gene eco:b4095 http://www.genome.jp/dbget-bin/www_bget?eco:b4095 KEGG_Orthology KO:K06162 http://www.genome.jp/dbget-bin/www_bget?KO:K06162 OMA WSQPNRQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WSQPNRQ PSORT swissprot:PHNM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PHNM_ECOLI PSORT-B swissprot:PHNM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PHNM_ECOLI PSORT2 swissprot:PHNM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PHNM_ECOLI Pfam PF07969 http://pfam.xfam.org/family/PF07969 Phobius swissprot:PHNM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PHNM_ECOLI PhylomeDB P16689 http://phylomedb.org/?seqid=P16689 ProteinModelPortal P16689 http://www.proteinmodelportal.org/query/uniprot/P16689 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1840580 http://www.ncbi.nlm.nih.gov/pubmed/1840580 PubMed 2155230 http://www.ncbi.nlm.nih.gov/pubmed/2155230 PubMed 22089136 http://www.ncbi.nlm.nih.gov/pubmed/22089136 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418519 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418519 RefSeq WP_000586325 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000586325 STRING 511145.b4095 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4095&targetmode=cogs STRING COG3454 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3454&targetmode=cogs SUPFAM SSF51338 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51338 SUPFAM SSF51556 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51556 TIGRFAMs TIGR02318 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02318 UniProtKB PHNM_ECOLI http://www.uniprot.org/uniprot/PHNM_ECOLI UniProtKB-AC P16689 http://www.uniprot.org/uniprot/P16689 charge swissprot:PHNM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PHNM_ECOLI eggNOG COG3454 http://eggnogapi.embl.de/nog_data/html/tree/COG3454 eggNOG ENOG4105FD8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FD8 epestfind swissprot:PHNM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PHNM_ECOLI garnier swissprot:PHNM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PHNM_ECOLI helixturnhelix swissprot:PHNM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PHNM_ECOLI hmoment swissprot:PHNM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PHNM_ECOLI iep swissprot:PHNM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PHNM_ECOLI inforesidue swissprot:PHNM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PHNM_ECOLI octanol swissprot:PHNM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PHNM_ECOLI pepcoil swissprot:PHNM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PHNM_ECOLI pepdigest swissprot:PHNM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PHNM_ECOLI pepinfo swissprot:PHNM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PHNM_ECOLI pepnet swissprot:PHNM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PHNM_ECOLI pepstats swissprot:PHNM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PHNM_ECOLI pepwheel swissprot:PHNM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PHNM_ECOLI pepwindow swissprot:PHNM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PHNM_ECOLI sigcleave swissprot:PHNM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PHNM_ECOLI ## Database ID URL or Descriptions # BioGrid 4259835 105 # CDD cd06660 Aldo_ket_red # EcoGene EG13611 yajO # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0016491 oxidoreductase activity; IEA:UniProtKB-KW. # GO_process GO:0006772 thiamine metabolic process; EXP:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.100 -; 1. # IntAct P77735 6 # InterPro IPR001395 Aldo/ket_red/Kv-b # InterPro IPR020471 Aldo/keto_reductase # InterPro IPR023210 NADP_OxRdtase_dom # Organism YAJO_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11732 PTHR11732; 2 # PATRIC 32115987 VBIEscCol129921_0435 # PIR C64771 C64771 # PRINTS PR00069 ALDKETRDTASE # Pfam PF00248 Aldo_ket_red # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAJO_ECOLI Uncharacterized oxidoreductase YajO # RefSeq NP_414953 NC_000913.3 # RefSeq WP_001199800 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40175.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily. {ECO 0000305}. # SUPFAM SSF51430 SSF51430 # TCDB 8.A.5.1 the voltage-gated k(+) channel -subunit (kv) family # eggNOG COG0667 LUCA # eggNOG ENOG4105CPC Bacteria BLAST swissprot:YAJO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAJO_ECOLI BioCyc ECOL316407:JW0409-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0409-MONOMER BioCyc EcoCyc:G6236-MONOMER http://biocyc.org/getid?id=EcoCyc:G6236-MONOMER BioCyc MetaCyc:G6236-MONOMER http://biocyc.org/getid?id=MetaCyc:G6236-MONOMER DIP DIP-11291N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11291N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- EchoBASE EB3377 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3377 EcoGene EG13611 http://www.ecogene.org/geneInfo.php?eg_id=EG13611 EnsemblBacteria AAC73522 http://www.ensemblgenomes.org/id/AAC73522 EnsemblBacteria AAC73522 http://www.ensemblgenomes.org/id/AAC73522 EnsemblBacteria BAE76199 http://www.ensemblgenomes.org/id/BAE76199 EnsemblBacteria BAE76199 http://www.ensemblgenomes.org/id/BAE76199 EnsemblBacteria BAE76199 http://www.ensemblgenomes.org/id/BAE76199 EnsemblBacteria b0419 http://www.ensemblgenomes.org/id/b0419 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_process GO:0006772 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006772 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.100 http://www.cathdb.info/version/latest/superfamily/3.20.20.100 GeneID 946903 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946903 HOGENOM HOG000250270 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000250270&db=HOGENOM6 InParanoid P77735 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77735 IntAct P77735 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77735* IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR001395 http://www.ebi.ac.uk/interpro/entry/IPR001395 InterPro IPR020471 http://www.ebi.ac.uk/interpro/entry/IPR020471 InterPro IPR023210 http://www.ebi.ac.uk/interpro/entry/IPR023210 KEGG_Gene ecj:JW0409 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0409 KEGG_Gene eco:b0419 http://www.genome.jp/dbget-bin/www_bget?eco:b0419 OMA SDWREWV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SDWREWV PANTHER PTHR11732 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11732 PRINTS PR00069 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00069 PSORT swissprot:YAJO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAJO_ECOLI PSORT-B swissprot:YAJO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAJO_ECOLI PSORT2 swissprot:YAJO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAJO_ECOLI Pfam PF00248 http://pfam.xfam.org/family/PF00248 Phobius swissprot:YAJO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAJO_ECOLI PhylomeDB P77735 http://phylomedb.org/?seqid=P77735 ProteinModelPortal P77735 http://www.proteinmodelportal.org/query/uniprot/P77735 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414953 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414953 RefSeq WP_001199800 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001199800 SMR P77735 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77735 STRING 511145.b0419 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0419&targetmode=cogs SUPFAM SSF51430 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51430 TCDB 8.A.5.1 http://www.tcdb.org/search/result.php?tc=8.A.5.1 UniProtKB YAJO_ECOLI http://www.uniprot.org/uniprot/YAJO_ECOLI UniProtKB-AC P77735 http://www.uniprot.org/uniprot/P77735 charge swissprot:YAJO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAJO_ECOLI eggNOG COG0667 http://eggnogapi.embl.de/nog_data/html/tree/COG0667 eggNOG ENOG4105CPC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CPC epestfind swissprot:YAJO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAJO_ECOLI garnier swissprot:YAJO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAJO_ECOLI helixturnhelix swissprot:YAJO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAJO_ECOLI hmoment swissprot:YAJO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAJO_ECOLI iep swissprot:YAJO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAJO_ECOLI inforesidue swissprot:YAJO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAJO_ECOLI octanol swissprot:YAJO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAJO_ECOLI pepcoil swissprot:YAJO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAJO_ECOLI pepdigest swissprot:YAJO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAJO_ECOLI pepinfo swissprot:YAJO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAJO_ECOLI pepnet swissprot:YAJO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAJO_ECOLI pepstats swissprot:YAJO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAJO_ECOLI pepwheel swissprot:YAJO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAJO_ECOLI pepwindow swissprot:YAJO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAJO_ECOLI sigcleave swissprot:YAJO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAJO_ECOLI ## Database ID URL or Descriptions # AltName TYPA_ECOLI Tyrosine phosphorylated protein A # BioGrid 4262631 10 # EcoGene EG11837 typA # FUNCTION TYPA_ECOLI Probably interacts with the ribosomes in a GTP dependent manner. GTPase that mediates interactions between enteropathogenic E.coli (EPEC) and epithelial cells. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003924 GTPase activity; IBA:GO_Central. # GO_function GO:0005525 GTP binding; IEA:UniProtKB-KW. # GO_process GO:0009408 response to heat; IMP:EcoCyc. # GO_process GO:0009409 response to cold; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003924 GTPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # Gene3D 3.30.70.240 -; 1. # Gene3D 3.40.50.300 -; 1. # INTERACTION TYPA_ECOLI P75864 rlmL; NbExp=3; IntAct=EBI-562154, EBI-547718; # IntAct P32132 5 # InterPro IPR000640 EFG_V # InterPro IPR000795 TF_GTP-bd_dom # InterPro IPR004161 EFTu-like_2 # InterPro IPR005225 Small_GTP-bd_dom # InterPro IPR006298 TypA_GTP-bd # InterPro IPR009000 Transl_B-barrel # InterPro IPR009022 EFG_III-V # InterPro IPR027417 P-loop_NTPase # InterPro IPR031157 G_TR_CS # Organism TYPA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR23115:SF14 PTHR23115:SF14 # PATRIC 32123245 VBIEscCol129921_3983 # PDB 4ZCI X-ray; 2.63 A; A/B=1-601 # PDB 4ZCK X-ray; 2.48 A; A=306-603 # PDB 4ZCL X-ray; 3.06 A; A/B=1-601 # PDB 4ZCM X-ray; 3.31 A; A/B=1-607 # PDB 5A9W X-ray; 3.70 A; A=1-607 # PDB 5A9X X-ray; 3.80 A; A=1-607 # PDB 5A9Y X-ray; 4.00 A; A=1-607 # PIR S40816 S40816 # PRINTS PR00315 ELONGATNFCT # PROSITE PS00301 G_TR_1 # PROSITE PS51722 G_TR_2 # PTM TYPA_ECOLI Phosphorylated on tyrosine residues. {ECO 0000269|PubMed 7783627, ECO 0000269|PubMed 9642082}. # Pfam PF00679 EFG_C # Pfam PF03144 GTP_EFTU_D2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TYPA_ECOLI GTP-binding protein TypA/BipA # RefSeq WP_000570668 NZ_LN832404.1 # RefSeq YP_026274 NC_000913.3 # SIMILARITY Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. TypA subfamily. {ECO:0000255|PROSITE-ProRule PRU01059}. # SIMILARITY Contains 1 tr-type G (guanine nucleotide-binding) domain. {ECO:0000255|PROSITE-ProRule PRU01059}. # SUPFAM SSF50447 SSF50447 # SUPFAM SSF52540 SSF52540 # SUPFAM SSF54980 SSF54980; 2 # TIGRFAMs TIGR00231 small_GTP # TIGRFAMs TIGR01394 TypA_BipA # eggNOG COG1217 LUCA # eggNOG ENOG4105CI3 Bacteria BLAST swissprot:TYPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TYPA_ECOLI BioCyc ECOL316407:JW5571-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5571-MONOMER BioCyc EcoCyc:EG11837-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11837-MONOMER COG COG1217 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1217 DIP DIP-11058N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11058N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1998.1836 http://dx.doi.org/10.1006/jmbi.1998.1836 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1998.00793.x http://dx.doi.org/10.1046/j.1365-2958.1998.00793.x DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1111/j.1365-2958.1995.tb02270.x http://dx.doi.org/10.1111/j.1365-2958.1995.tb02270.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AJ224871 http://www.ebi.ac.uk/ena/data/view/AJ224871 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1783 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1783 EcoGene EG11837 http://www.ecogene.org/geneInfo.php?eg_id=EG11837 EnsemblBacteria AAT48232 http://www.ensemblgenomes.org/id/AAT48232 EnsemblBacteria AAT48232 http://www.ensemblgenomes.org/id/AAT48232 EnsemblBacteria BAE77438 http://www.ensemblgenomes.org/id/BAE77438 EnsemblBacteria BAE77438 http://www.ensemblgenomes.org/id/BAE77438 EnsemblBacteria BAE77438 http://www.ensemblgenomes.org/id/BAE77438 EnsemblBacteria b3871 http://www.ensemblgenomes.org/id/b3871 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GO_process GO:0009409 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009409 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.30.70.240 http://www.cathdb.info/version/latest/superfamily/3.30.70.240 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948369 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948369 HOGENOM HOG000282351 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000282351&db=HOGENOM6 InParanoid P32132 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32132 IntAct P32132 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32132* InterPro IPR000640 http://www.ebi.ac.uk/interpro/entry/IPR000640 InterPro IPR000795 http://www.ebi.ac.uk/interpro/entry/IPR000795 InterPro IPR004161 http://www.ebi.ac.uk/interpro/entry/IPR004161 InterPro IPR005225 http://www.ebi.ac.uk/interpro/entry/IPR005225 InterPro IPR006298 http://www.ebi.ac.uk/interpro/entry/IPR006298 InterPro IPR009000 http://www.ebi.ac.uk/interpro/entry/IPR009000 InterPro IPR009022 http://www.ebi.ac.uk/interpro/entry/IPR009022 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR031157 http://www.ebi.ac.uk/interpro/entry/IPR031157 KEGG_Gene ecj:JW5571 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5571 KEGG_Gene eco:b3871 http://www.genome.jp/dbget-bin/www_bget?eco:b3871 KEGG_Orthology KO:K06207 http://www.genome.jp/dbget-bin/www_bget?KO:K06207 OMA SMLFTIN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SMLFTIN PANTHER PTHR23115:SF14 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23115:SF14 PDB 4ZCI http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZCI PDB 4ZCK http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZCK PDB 4ZCL http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZCL PDB 4ZCM http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZCM PDB 5A9W http://www.ebi.ac.uk/pdbe-srv/view/entry/5A9W PDB 5A9X http://www.ebi.ac.uk/pdbe-srv/view/entry/5A9X PDB 5A9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/5A9Y PDBsum 4ZCI http://www.ebi.ac.uk/pdbsum/4ZCI PDBsum 4ZCK http://www.ebi.ac.uk/pdbsum/4ZCK PDBsum 4ZCL http://www.ebi.ac.uk/pdbsum/4ZCL PDBsum 4ZCM http://www.ebi.ac.uk/pdbsum/4ZCM PDBsum 5A9W http://www.ebi.ac.uk/pdbsum/5A9W PDBsum 5A9X http://www.ebi.ac.uk/pdbsum/5A9X PDBsum 5A9Y http://www.ebi.ac.uk/pdbsum/5A9Y PRINTS PR00315 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00315 PROSITE PS00301 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00301 PROSITE PS51722 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51722 PSORT swissprot:TYPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TYPA_ECOLI PSORT-B swissprot:TYPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TYPA_ECOLI PSORT2 swissprot:TYPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TYPA_ECOLI Pfam PF00679 http://pfam.xfam.org/family/PF00679 Pfam PF03144 http://pfam.xfam.org/family/PF03144 Phobius swissprot:TYPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TYPA_ECOLI PhylomeDB P32132 http://phylomedb.org/?seqid=P32132 ProteinModelPortal P32132 http://www.proteinmodelportal.org/query/uniprot/P32132 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7783627 http://www.ncbi.nlm.nih.gov/pubmed/7783627 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9622352 http://www.ncbi.nlm.nih.gov/pubmed/9622352 PubMed 9642082 http://www.ncbi.nlm.nih.gov/pubmed/9642082 RefSeq WP_000570668 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000570668 RefSeq YP_026274 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026274 SMR P32132 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32132 STRING 511145.b3871 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3871&targetmode=cogs STRING COG1217 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1217&targetmode=cogs SUPFAM SSF50447 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50447 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SUPFAM SSF54980 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54980 TIGRFAMs TIGR00231 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00231 TIGRFAMs TIGR01394 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01394 UniProtKB TYPA_ECOLI http://www.uniprot.org/uniprot/TYPA_ECOLI UniProtKB-AC P32132 http://www.uniprot.org/uniprot/P32132 charge swissprot:TYPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TYPA_ECOLI eggNOG COG1217 http://eggnogapi.embl.de/nog_data/html/tree/COG1217 eggNOG ENOG4105CI3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CI3 epestfind swissprot:TYPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TYPA_ECOLI garnier swissprot:TYPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TYPA_ECOLI helixturnhelix swissprot:TYPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TYPA_ECOLI hmoment swissprot:TYPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TYPA_ECOLI iep swissprot:TYPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TYPA_ECOLI inforesidue swissprot:TYPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TYPA_ECOLI octanol swissprot:TYPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TYPA_ECOLI pepcoil swissprot:TYPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TYPA_ECOLI pepdigest swissprot:TYPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TYPA_ECOLI pepinfo swissprot:TYPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TYPA_ECOLI pepnet swissprot:TYPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TYPA_ECOLI pepstats swissprot:TYPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TYPA_ECOLI pepwheel swissprot:TYPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TYPA_ECOLI pepwindow swissprot:TYPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TYPA_ECOLI sigcleave swissprot:TYPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TYPA_ECOLI ## Database ID URL or Descriptions # AltName FOLX_ECOLI D-erythro-7,8-dihydroneopterin triphosphate epimerase # BIOPHYSICOCHEMICAL PROPERTIES FOLX_ECOLI Kinetic parameters KM=13 uM for 7,8-dihydroneopterin triphosphate {ECO 0000269|PubMed 9651328}; KM=149 uM for 7,8-dihydroneopterin {ECO 0000269|PubMed 9651328}; KM=66 uM for 7,8-dihydromonapterin {ECO 0000269|PubMed 9651328}; Vmax=480 umol/h/mg enzyme for the epimerization of 7,8- dihydroneopterin triphosphate {ECO 0000269|PubMed 9651328}; Vmax=0.95 umol/h/mg enzyme for the epimerization of 7,8- dihydroneopterin {ECO 0000269|PubMed 9651328}; Vmax=0.67 umol/h/mg enzyme for the epimerization of 7,8- dihydromonapterin {ECO 0000269|PubMed 9651328}; # BioGrid 4260518 7 # CATALYTIC ACTIVITY FOLX_ECOLI 7,8-dihydroneopterin 3'-triphosphate = 7,8- dihydromonapterin 3'-triphosphate. {ECO 0000269|PubMed 9182560, ECO 0000269|PubMed 9651328}. # CDD cd00534 DHNA_DHNTPE # DISRUPTION PHENOTYPE FOLX_ECOLI Cells lacking this gene show no detectable growth defect on complete and minimal medium (PubMed 9651328). The folX deletion selectively eliminates monapterin production and secretion, but has no effect on the intra- and extracellular folate profiles (PubMed 19897652). {ECO 0000269|PubMed 19897652, ECO 0000269|PubMed 9651328}. # EcoGene EG14263 folX # FUNCTION FOLX_ECOLI Catalyzes the epimerization of carbon 2' of the side chain of 7,8-dihydroneopterin triphosphate (H2NTP) to form 7,8- dihydromonapterin triphosphate (H2MTP) (PubMed 9182560) (PubMed 9651328). Is required for tetrahydromonapterin biosynthesis, a major pterin in E.coli (PubMed 19897652). {ECO 0000269|PubMed 19897652, ECO 0000269|PubMed 9182560, ECO 0000269|PubMed 9651328}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004150 dihydroneopterin aldolase activity; IEA:InterPro. # GO_function GO:0008719 dihydroneopterin triphosphate 2'-epimerase activity; IDA:EcoliWiki. # GO_process GO:0006760 folic acid-containing compound metabolic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # IntAct P0AC19 3 # InterPro IPR006157 FolB_dom # KEGG_Brite ko01000 Enzymes # Organism FOLX_ECOLI Escherichia coli (strain K12) # PATRIC 32119977 VBIEscCol129921_2398 # PDB 1B9L X-ray; 2.90 A; A/B/C/D/E/F/G/H=1-120 # PIR E65002 E65002 # Pfam PF02152 FolB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Dihydroneopterin triphosphate 2'-epimerase {ECO:0000303|PubMed 9182560} # RefSeq NP_416806 NC_000913.3 # RefSeq WP_000068457 NZ_LN832404.1 # SIMILARITY Belongs to the DHNA family. {ECO 0000305}. # SMART SM00905 FolB # SUBUNIT FOLX_ECOLI Homooctamer. {ECO 0000269|PubMed 10378270, ECO 0000269|PubMed 9651328}. # TIGRFAMs TIGR00526 folB_dom # eggNOG COG1539 LUCA # eggNOG ENOG4105KKP Bacteria BLAST swissprot:FOLX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FOLX_ECOLI BioCyc ECOL316407:JW2300-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2300-MONOMER BioCyc EcoCyc:H2NTPEPIM-MONOMER http://biocyc.org/getid?id=EcoCyc:H2NTPEPIM-MONOMER BioCyc MetaCyc:H2NTPEPIM-MONOMER http://biocyc.org/getid?id=MetaCyc:H2NTPEPIM-MONOMER COG COG1539 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1539 DIP DIP-9679N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9679N DOI 10.1016/S0969-2126(99)80067-7 http://dx.doi.org/10.1016/S0969-2126(99)80067-7 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.272.24.15323 http://dx.doi.org/10.1074/jbc.272.24.15323 DOI 10.1074/jbc.273.28.17418 http://dx.doi.org/10.1074/jbc.273.28.17418 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01198-09 http://dx.doi.org/10.1128/JB.01198-09 EC_number EC:5.1.99.- {ECO:0000269|PubMed:9182560, ECO:0000269|PubMed:9651328} http://www.genome.jp/dbget-bin/www_bget?EC:5.1.99.- {ECO:0000269|PubMed:9182560, ECO:0000269|PubMed:9651328} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U47639 http://www.ebi.ac.uk/ena/data/view/U47639 EMBL X96709 http://www.ebi.ac.uk/ena/data/view/X96709 ENZYME 5.1.99.- {ECO:0000269|PubMed:9182560, ECO:0000269|PubMed:9651328} http://enzyme.expasy.org/EC/5.1.99.- {ECO:0000269|PubMed:9182560, ECO:0000269|PubMed:9651328} EchoBASE EB4011 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4011 EcoGene EG14263 http://www.ecogene.org/geneInfo.php?eg_id=EG14263 EnsemblBacteria AAC75363 http://www.ensemblgenomes.org/id/AAC75363 EnsemblBacteria AAC75363 http://www.ensemblgenomes.org/id/AAC75363 EnsemblBacteria BAA16140 http://www.ensemblgenomes.org/id/BAA16140 EnsemblBacteria BAA16140 http://www.ensemblgenomes.org/id/BAA16140 EnsemblBacteria BAA16140 http://www.ensemblgenomes.org/id/BAA16140 EnsemblBacteria b2303 http://www.ensemblgenomes.org/id/b2303 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004150 GO_function GO:0008719 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008719 GO_process GO:0006760 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006760 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GeneID 946781 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946781 HOGENOM HOG000217626 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000217626&db=HOGENOM6 InParanoid P0AC19 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AC19 IntAct P0AC19 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AC19* IntEnz 5.1.99.- {ECO:0000269|PubMed:9182560, ECO:0000269|PubMed:9651328} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.1.99.- {ECO:0000269|PubMed:9182560, ECO:0000269|PubMed:9651328} InterPro IPR006157 http://www.ebi.ac.uk/interpro/entry/IPR006157 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2300 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2300 KEGG_Gene eco:b2303 http://www.genome.jp/dbget-bin/www_bget?eco:b2303 KEGG_Orthology KO:K07589 http://www.genome.jp/dbget-bin/www_bget?KO:K07589 OMA TKAIIAH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TKAIIAH PDB 1B9L http://www.ebi.ac.uk/pdbe-srv/view/entry/1B9L PDBsum 1B9L http://www.ebi.ac.uk/pdbsum/1B9L PSORT swissprot:FOLX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FOLX_ECOLI PSORT-B swissprot:FOLX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FOLX_ECOLI PSORT2 swissprot:FOLX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FOLX_ECOLI Pfam PF02152 http://pfam.xfam.org/family/PF02152 Phobius swissprot:FOLX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FOLX_ECOLI PhylomeDB P0AC19 http://phylomedb.org/?seqid=P0AC19 ProteinModelPortal P0AC19 http://www.proteinmodelportal.org/query/uniprot/P0AC19 PubMed 10378270 http://www.ncbi.nlm.nih.gov/pubmed/10378270 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19897652 http://www.ncbi.nlm.nih.gov/pubmed/19897652 PubMed 9006053 http://www.ncbi.nlm.nih.gov/pubmed/9006053 PubMed 9182560 http://www.ncbi.nlm.nih.gov/pubmed/9182560 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9651328 http://www.ncbi.nlm.nih.gov/pubmed/9651328 RefSeq NP_416806 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416806 RefSeq WP_000068457 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000068457 SMART SM00905 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00905 SMR P0AC19 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AC19 STRING 511145.b2303 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2303&targetmode=cogs STRING COG1539 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1539&targetmode=cogs TIGRFAMs TIGR00526 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00526 UniProtKB FOLX_ECOLI http://www.uniprot.org/uniprot/FOLX_ECOLI UniProtKB-AC P0AC19 http://www.uniprot.org/uniprot/P0AC19 charge swissprot:FOLX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FOLX_ECOLI eggNOG COG1539 http://eggnogapi.embl.de/nog_data/html/tree/COG1539 eggNOG ENOG4105KKP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KKP epestfind swissprot:FOLX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FOLX_ECOLI garnier swissprot:FOLX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FOLX_ECOLI helixturnhelix swissprot:FOLX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FOLX_ECOLI hmoment swissprot:FOLX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FOLX_ECOLI iep swissprot:FOLX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FOLX_ECOLI inforesidue swissprot:FOLX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FOLX_ECOLI octanol swissprot:FOLX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FOLX_ECOLI pepcoil swissprot:FOLX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FOLX_ECOLI pepdigest swissprot:FOLX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FOLX_ECOLI pepinfo swissprot:FOLX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FOLX_ECOLI pepnet swissprot:FOLX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FOLX_ECOLI pepstats swissprot:FOLX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FOLX_ECOLI pepwheel swissprot:FOLX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FOLX_ECOLI pepwindow swissprot:FOLX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FOLX_ECOLI sigcleave swissprot:FOLX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FOLX_ECOLI ## Database ID URL or Descriptions # BioGrid 4262908 22 # EcoGene EG12140 ydhB # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # IntAct P0ACR2 5 # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR005119 LysR_subst-bd # InterPro IPR011991 WHTH_DNA-bd_dom # Organism YDHB_ECOLI Escherichia coli (strain K12) # PATRIC 32118624 VBIEscCol129921_1732 # PIR E64923 E64923 # PROSITE PS50931 HTH_LYSR # Pfam PF00126 HTH_1 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDHB_ECOLI Uncharacterized HTH-type transcriptional regulator YdhB # RefSeq NP_416176 NC_000913.3 # RefSeq WP_000269501 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lysR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00253}. # SUPFAM SSF46785 SSF46785 # eggNOG ENOG4105F52 Bacteria # eggNOG ENOG410XT26 LUCA BLAST swissprot:YDHB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDHB_ECOLI BioCyc ECOL316407:JW1651-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1651-MONOMER BioCyc EcoCyc:EG12140-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12140-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1111/j.1432-1033.1990.tb15314.x http://dx.doi.org/10.1111/j.1432-1033.1990.tb15314.x DOI 10.1111/j.1432-1033.1996.0712r.x http://dx.doi.org/10.1111/j.1432-1033.1996.0712r.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X51368 http://www.ebi.ac.uk/ena/data/view/X51368 EMBL X69109 http://www.ebi.ac.uk/ena/data/view/X69109 EchoBASE EB2061 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2061 EcoGene EG12140 http://www.ecogene.org/geneInfo.php?eg_id=EG12140 EnsemblBacteria AAC74731 http://www.ensemblgenomes.org/id/AAC74731 EnsemblBacteria AAC74731 http://www.ensemblgenomes.org/id/AAC74731 EnsemblBacteria BAA15425 http://www.ensemblgenomes.org/id/BAA15425 EnsemblBacteria BAA15425 http://www.ensemblgenomes.org/id/BAA15425 EnsemblBacteria BAA15425 http://www.ensemblgenomes.org/id/BAA15425 EnsemblBacteria b1659 http://www.ensemblgenomes.org/id/b1659 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 945208 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945208 HOGENOM HOG000181313 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000181313&db=HOGENOM6 InParanoid P0ACR2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACR2 IntAct P0ACR2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACR2* InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW1651 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1651 KEGG_Gene eco:b1659 http://www.genome.jp/dbget-bin/www_bget?eco:b1659 OMA PKRTTWL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PKRTTWL PROSITE PS50931 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50931 PSORT swissprot:YDHB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDHB_ECOLI PSORT-B swissprot:YDHB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDHB_ECOLI PSORT2 swissprot:YDHB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDHB_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:YDHB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDHB_ECOLI PhylomeDB P0ACR2 http://phylomedb.org/?seqid=P0ACR2 ProteinModelPortal P0ACR2 http://www.proteinmodelportal.org/query/uniprot/P0ACR2 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2404765 http://www.ncbi.nlm.nih.gov/pubmed/2404765 PubMed 9022701 http://www.ncbi.nlm.nih.gov/pubmed/9022701 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416176 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416176 RefSeq WP_000269501 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000269501 SMR P0ACR2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACR2 STRING 511145.b1659 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1659&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB YDHB_ECOLI http://www.uniprot.org/uniprot/YDHB_ECOLI UniProtKB-AC P0ACR2 http://www.uniprot.org/uniprot/P0ACR2 charge swissprot:YDHB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDHB_ECOLI eggNOG ENOG4105F52 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F52 eggNOG ENOG410XT26 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XT26 epestfind swissprot:YDHB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDHB_ECOLI garnier swissprot:YDHB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDHB_ECOLI helixturnhelix swissprot:YDHB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDHB_ECOLI hmoment swissprot:YDHB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDHB_ECOLI iep swissprot:YDHB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDHB_ECOLI inforesidue swissprot:YDHB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDHB_ECOLI octanol swissprot:YDHB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDHB_ECOLI pepcoil swissprot:YDHB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDHB_ECOLI pepdigest swissprot:YDHB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDHB_ECOLI pepinfo swissprot:YDHB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDHB_ECOLI pepnet swissprot:YDHB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDHB_ECOLI pepstats swissprot:YDHB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDHB_ECOLI pepwheel swissprot:YDHB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDHB_ECOLI pepwindow swissprot:YDHB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDHB_ECOLI sigcleave swissprot:YDHB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDHB_ECOLI ## Database ID URL or Descriptions # AltName Potassium/proton antiporter NhaP2 {ECO:0000255|HAMAP-Rule MF_01075} # BioGrid 4261367 11 # EcoGene EG13896 cvrA # FUNCTION NHAP2_ECOLI K(+)/H(+) antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels (By similarity). Participates in control of cell volume in low-osmolarity conditions. {ECO 0000255|HAMAP-Rule MF_01075, ECO 0000269|PubMed 11700351}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IEA:UniProtKB-HAMAP. # GO_component GO:0016021 integral component of membrane; IDA:EcoCyc. # GO_function GO:0015459 potassium channel regulator activity; IEA:UniProtKB-HAMAP. # GO_function GO:0016614 oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro. # GO_function GO:0050660 flavin adenine dinucleotide binding; IEA:InterPro. # GO_function NHAP2_ECOLI GO 0015386 potassium proton antiporter activity; IEA UniProtKB-HAMAP. # GO_process GO:0006884 cell volume homeostasis; IMP:EcoCyc. # GO_process GO:0043266 regulation of potassium ion transport; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0042592 homeostatic process # Gene3D 3.30.465.10 -; 1. # Gene3D 3.30.70.1450 -; 1. # HAMAP MF_01075 NhaP2 # InterPro IPR005170 Transptr-assoc_dom # InterPro IPR006037 RCK_C # InterPro IPR006153 Cation/H_exchanger # InterPro IPR016166 FAD-bd_2 # InterPro IPR016169 CO_DH_flavot_FAD-bd_sub2 # InterPro IPR023729 NhaP2 # InterPro IPR030151 NhaP # Organism NHAP2_ECOLI Escherichia coli (strain K12) # PANTHER PTHR32507:SF7 PTHR32507:SF7 # PATRIC 32117630 VBIEscCol129921_1237 # PIR D64865 D64865 # PROSITE PS51202 RCK_C # Pfam PF00999 Na_H_Exchanger # Pfam PF02080 TrkA_C # Pfam PF03471 CorC_HlyC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName K(+)/H(+) antiporter NhaP2 {ECO:0000255|HAMAP-Rule MF_01075} # RefSeq NP_415709 NC_000913.3 # RefSeq WP_000340194 NZ_LN832404.1 # SIMILARITY Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. NhaP2 subfamily. {ECO 0000255|HAMAP-Rule:MF_01075}. # SIMILARITY Contains 1 RCK C-terminal domain. {ECO:0000255|HAMAP- Rule MF_01075}. # SMART SM01091 CorC_HlyC # SUBCELLULAR LOCATION NHAP2_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01075}; Multi-pass membrane protein {ECO 0000255|HAMAP- Rule MF_01075}. # SUPFAM SSF116726 SSF116726 # SUPFAM SSF56176 SSF56176 # TCDB 2.A.36.6.11:the monovalent cation proton antiporter-1 (cpa1) family # eggNOG COG3263 LUCA # eggNOG ENOG4105C3N Bacteria BLAST swissprot:NHAP2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NHAP2_ECOLI BioCyc ECOL316407:JW5184-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5184-MONOMER BioCyc EcoCyc:YCGO-MONOMER http://biocyc.org/getid?id=EcoCyc:YCGO-MONOMER COG COG3263 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3263 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3655 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3655 EcoGene EG13896 http://www.ecogene.org/geneInfo.php?eg_id=EG13896 EnsemblBacteria AAC74275 http://www.ensemblgenomes.org/id/AAC74275 EnsemblBacteria AAC74275 http://www.ensemblgenomes.org/id/AAC74275 EnsemblBacteria BAA36046 http://www.ensemblgenomes.org/id/BAA36046 EnsemblBacteria BAA36046 http://www.ensemblgenomes.org/id/BAA36046 EnsemblBacteria BAA36046 http://www.ensemblgenomes.org/id/BAA36046 EnsemblBacteria b1191 http://www.ensemblgenomes.org/id/b1191 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015386 GO_function GO:0015459 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015459 GO_function GO:0016614 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016614 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_process GO:0006884 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006884 GO_process GO:0043266 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043266 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 Gene3D 3.30.465.10 http://www.cathdb.info/version/latest/superfamily/3.30.465.10 Gene3D 3.30.70.1450 http://www.cathdb.info/version/latest/superfamily/3.30.70.1450 GeneID 945755 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945755 HAMAP MF_01075 http://hamap.expasy.org/unirule/MF_01075 HOGENOM HOG000019567 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000019567&db=HOGENOM6 InParanoid P76007 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76007 IntAct P76007 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76007* InterPro IPR005170 http://www.ebi.ac.uk/interpro/entry/IPR005170 InterPro IPR006037 http://www.ebi.ac.uk/interpro/entry/IPR006037 InterPro IPR006153 http://www.ebi.ac.uk/interpro/entry/IPR006153 InterPro IPR016166 http://www.ebi.ac.uk/interpro/entry/IPR016166 InterPro IPR016169 http://www.ebi.ac.uk/interpro/entry/IPR016169 InterPro IPR023729 http://www.ebi.ac.uk/interpro/entry/IPR023729 InterPro IPR030151 http://www.ebi.ac.uk/interpro/entry/IPR030151 KEGG_Gene ecj:JW5184 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5184 KEGG_Gene eco:b1191 http://www.genome.jp/dbget-bin/www_bget?eco:b1191 KEGG_Orthology KO:K11105 http://www.genome.jp/dbget-bin/www_bget?KO:K11105 OMA FRFNWRE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FRFNWRE PANTHER PTHR32507:SF7 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32507:SF7 PROSITE PS51202 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51202 PSORT swissprot:NHAP2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NHAP2_ECOLI PSORT-B swissprot:NHAP2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NHAP2_ECOLI PSORT2 swissprot:NHAP2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NHAP2_ECOLI Pfam PF00999 http://pfam.xfam.org/family/PF00999 Pfam PF02080 http://pfam.xfam.org/family/PF02080 Pfam PF03471 http://pfam.xfam.org/family/PF03471 Phobius swissprot:NHAP2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NHAP2_ECOLI PhylomeDB P76007 http://phylomedb.org/?seqid=P76007 ProteinModelPortal P76007 http://www.proteinmodelportal.org/query/uniprot/P76007 PubMed 11700351 http://www.ncbi.nlm.nih.gov/pubmed/11700351 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415709 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415709 RefSeq WP_000340194 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000340194 SMART SM01091 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01091 STRING 511145.b1191 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1191&targetmode=cogs STRING COG3263 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3263&targetmode=cogs SUPFAM SSF116726 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF116726 SUPFAM SSF56176 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56176 TCDB 2.A.36.6.11 http://www.tcdb.org/search/result.php?tc=2.A.36.6.11 UniProtKB NHAP2_ECOLI http://www.uniprot.org/uniprot/NHAP2_ECOLI UniProtKB-AC P76007 http://www.uniprot.org/uniprot/P76007 charge swissprot:NHAP2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NHAP2_ECOLI eggNOG COG3263 http://eggnogapi.embl.de/nog_data/html/tree/COG3263 eggNOG ENOG4105C3N http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C3N epestfind swissprot:NHAP2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NHAP2_ECOLI garnier swissprot:NHAP2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NHAP2_ECOLI helixturnhelix swissprot:NHAP2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NHAP2_ECOLI hmoment swissprot:NHAP2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NHAP2_ECOLI iep swissprot:NHAP2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NHAP2_ECOLI inforesidue swissprot:NHAP2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NHAP2_ECOLI octanol swissprot:NHAP2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NHAP2_ECOLI pepcoil swissprot:NHAP2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NHAP2_ECOLI pepdigest swissprot:NHAP2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NHAP2_ECOLI pepinfo swissprot:NHAP2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NHAP2_ECOLI pepnet swissprot:NHAP2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NHAP2_ECOLI pepstats swissprot:NHAP2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NHAP2_ECOLI pepwheel swissprot:NHAP2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NHAP2_ECOLI pepwindow swissprot:NHAP2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NHAP2_ECOLI sigcleave swissprot:NHAP2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NHAP2_ECOLI ## Database ID URL or Descriptions # BioGrid 4261373 153 # EcoGene EG12269 yhjY # GO_component GO:0019867 outer membrane; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # Gene3D 2.40.128.130 -; 1. # InterPro IPR005546 Autotransporte_beta # InterPro IPR006315 OM_autotransptr_brl # InterPro IPR016955 Autotranspt_YhjY_prd # Organism YHJY_ECOLI Escherichia coli (strain K12) # PATRIC 32122568 VBIEscCol129921_3661 # PIR S47769 S47769 # PIRSF PIRSF030748 Autotransporter_YhjY_prd # PROSITE PS51208 AUTOTRANSPORTER # Pfam PF03797 Autotransporter # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHJY_ECOLI Uncharacterized protein YhjY # RefSeq NP_418004 NC_000913.3 # RefSeq WP_001299523 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18525.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Contains 1 autotransporter (TC 1.B.12) domain. {ECO:0000255|PROSITE-ProRule PRU00556}. # SUPFAM SSF103515 SSF103515 # TIGRFAMs TIGR01414 autotrans_barl # eggNOG COG5571 LUCA # eggNOG ENOG4105EAX Bacteria BLAST swissprot:YHJY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHJY_ECOLI BioCyc ECOL316407:JW5659-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5659-MONOMER BioCyc EcoCyc:EG12269-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12269-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2178 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2178 EcoGene EG12269 http://www.ecogene.org/geneInfo.php?eg_id=EG12269 EnsemblBacteria AAC76572 http://www.ensemblgenomes.org/id/AAC76572 EnsemblBacteria AAC76572 http://www.ensemblgenomes.org/id/AAC76572 EnsemblBacteria BAE77747 http://www.ensemblgenomes.org/id/BAE77747 EnsemblBacteria BAE77747 http://www.ensemblgenomes.org/id/BAE77747 EnsemblBacteria BAE77747 http://www.ensemblgenomes.org/id/BAE77747 EnsemblBacteria b3548 http://www.ensemblgenomes.org/id/b3548 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0019867 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019867 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 Gene3D 2.40.128.130 http://www.cathdb.info/version/latest/superfamily/2.40.128.130 GeneID 948073 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948073 HOGENOM HOG000125992 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125992&db=HOGENOM6 InterPro IPR005546 http://www.ebi.ac.uk/interpro/entry/IPR005546 InterPro IPR006315 http://www.ebi.ac.uk/interpro/entry/IPR006315 InterPro IPR016955 http://www.ebi.ac.uk/interpro/entry/IPR016955 KEGG_Gene ecj:JW5659 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5659 KEGG_Gene eco:b3548 http://www.genome.jp/dbget-bin/www_bget?eco:b3548 OMA SERYTWD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SERYTWD PROSITE PS51208 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51208 PSORT swissprot:YHJY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHJY_ECOLI PSORT-B swissprot:YHJY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHJY_ECOLI PSORT2 swissprot:YHJY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHJY_ECOLI Pfam PF03797 http://pfam.xfam.org/family/PF03797 Phobius swissprot:YHJY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHJY_ECOLI ProteinModelPortal P37663 http://www.proteinmodelportal.org/query/uniprot/P37663 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418004 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418004 RefSeq WP_001299523 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001299523 STRING 511145.b3548 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3548&targetmode=cogs SUPFAM SSF103515 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103515 TIGRFAMs TIGR01414 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01414 UniProtKB YHJY_ECOLI http://www.uniprot.org/uniprot/YHJY_ECOLI UniProtKB-AC P37663 http://www.uniprot.org/uniprot/P37663 charge swissprot:YHJY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHJY_ECOLI eggNOG COG5571 http://eggnogapi.embl.de/nog_data/html/tree/COG5571 eggNOG ENOG4105EAX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EAX epestfind swissprot:YHJY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHJY_ECOLI garnier swissprot:YHJY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHJY_ECOLI helixturnhelix swissprot:YHJY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHJY_ECOLI hmoment swissprot:YHJY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHJY_ECOLI iep swissprot:YHJY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHJY_ECOLI inforesidue swissprot:YHJY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHJY_ECOLI octanol swissprot:YHJY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHJY_ECOLI pepcoil swissprot:YHJY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHJY_ECOLI pepdigest swissprot:YHJY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHJY_ECOLI pepinfo swissprot:YHJY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHJY_ECOLI pepnet swissprot:YHJY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHJY_ECOLI pepstats swissprot:YHJY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHJY_ECOLI pepwheel swissprot:YHJY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHJY_ECOLI pepwindow swissprot:YHJY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHJY_ECOLI sigcleave swissprot:YHJY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHJY_ECOLI ## Database ID URL or Descriptions # AltName TSAB_ECOLI t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaB # BioGrid 4260340 15 # CAUTION The well-known t(6)A modification appears to be a hydrolyzed artifact of natural cyclic t(6)A (ct(6)A) that occurs during the preparation and handling of tRNA in E.coli and many other species (PubMed:23242255). In these species, the t(6)A modification is processed further by dehydration into ct(6)A, a reaction catalyzed by TcdA. {ECO 0000305}. # DISRUPTION PHENOTYPE Appears essential for growth, since no null mutants can be obtained. Conditional depletion of this gene leads to enlarged cells, which display highly condensed nucleoids. The TsaB depletion phenotype is suppressed by overexpressing the response regulator RstA. {ECO:0000269|PubMed 19376873}. # EcoGene EG13512 tsaB # FUNCTION TSAB_ECOLI Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaE. TsaB seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD. In fact, can act as a protease that specifically degrades TsaD in vitro; therefore TsaB may post-translationally regulate cellular pools of TsaD via proteolytic degradation. Does not show sialoglycoprotease activity against glycophorin A. {ECO 0000269|PubMed 19376873, ECO 0000269|PubMed 22378793}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008237 metallopeptidase activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0002949 tRNA threonylcarbamoyladenosine modification; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008233 peptidase activity # GOslim_process GO:0006399 tRNA metabolic process # INTERACTION TSAB_ECOLI P05852 tsaD; NbExp=6; IntAct=EBI-560669, EBI-561994; # IntAct P76256 12 # InterPro IPR000905 Gcp-like_dom # InterPro IPR022496 T6A_YeaZ # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # MISCELLANEOUS TsaBCDE are necessary and sufficient for tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification in vitro in E.coli. {ECO:0000305|PubMed 22378793}. # Organism TSAB_ECOLI Escherichia coli (strain K12) # PATRIC 32118931 VBIEscCol129921_1883 # PDB 1OKJ X-ray; 2.28 A; A/B/C/D=2-231 # PDB 4WQ4 X-ray; 2.33 A; C/D=1-231 # PDB 4WQ5 X-ray; 2.33 A; C/D=1-231 # PDB 4YDU X-ray; 2.33 A; C/D=1-231 # PIR G64941 G64941 # Pfam PF00814 Peptidase_M22 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TSAB_ECOLI tRNA threonylcarbamoyladenosine biosynthesis protein TsaB # RefSeq NP_416321 NC_000913.3 # RefSeq WP_001220966 NZ_LN832404.1 # SIMILARITY Belongs to the KAE1 / TsaD family. TsaB subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION TSAB_ECOLI Cytoplasm {ECO 0000269|PubMed 19376873}. # SUBUNIT TSAB_ECOLI Homodimer. Interacts with TsaD and TsaE in a mutually exclusive manner; TsaD is the preferred partner. Also interacts with TsaC. {ECO 0000269|PubMed 19376873, ECO 0000269|PubMed 20701780, ECO 0000269|PubMed 22378793}. # TIGRFAMs TIGR03725 T6A_YeaZ # eggNOG COG1214 LUCA # eggNOG ENOG41072GX Bacteria BLAST swissprot:TSAB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TSAB_ECOLI BioCyc ECOL316407:JW1796-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1796-MONOMER BioCyc EcoCyc:G6991-MONOMER http://biocyc.org/getid?id=EcoCyc:G6991-MONOMER BioCyc MetaCyc:G6991-MONOMER http://biocyc.org/getid?id=MetaCyc:G6991-MONOMER COG COG1214 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1214 DIP DIP-11804N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11804N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M112.344028 http://dx.doi.org/10.1074/jbc.M112.344028 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1107/S1744309105025856 http://dx.doi.org/10.1107/S1744309105025856 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00136-09 http://dx.doi.org/10.1128/JB.00136-09 DOI 10.1186/1471-2164-11-470 http://dx.doi.org/10.1186/1471-2164-11-470 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3285 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3285 EcoGene EG13512 http://www.ecogene.org/geneInfo.php?eg_id=EG13512 EnsemblBacteria AAC74877 http://www.ensemblgenomes.org/id/AAC74877 EnsemblBacteria AAC74877 http://www.ensemblgenomes.org/id/AAC74877 EnsemblBacteria BAA15611 http://www.ensemblgenomes.org/id/BAA15611 EnsemblBacteria BAA15611 http://www.ensemblgenomes.org/id/BAA15611 EnsemblBacteria BAA15611 http://www.ensemblgenomes.org/id/BAA15611 EnsemblBacteria b1807 http://www.ensemblgenomes.org/id/b1807 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008237 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008237 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0002949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002949 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GeneID 946304 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946304 HOGENOM HOG000052125 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000052125&db=HOGENOM6 InParanoid P76256 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76256 IntAct P76256 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76256* InterPro IPR000905 http://www.ebi.ac.uk/interpro/entry/IPR000905 InterPro IPR022496 http://www.ebi.ac.uk/interpro/entry/IPR022496 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW1796 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1796 KEGG_Gene eco:b1807 http://www.genome.jp/dbget-bin/www_bget?eco:b1807 KEGG_Orthology KO:K14742 http://www.genome.jp/dbget-bin/www_bget?KO:K14742 MINT MINT-1255819 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1255819 OMA DWFGAGT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DWFGAGT PDB 1OKJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1OKJ PDB 4WQ4 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WQ4 PDB 4WQ5 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WQ5 PDB 4YDU http://www.ebi.ac.uk/pdbe-srv/view/entry/4YDU PDBsum 1OKJ http://www.ebi.ac.uk/pdbsum/1OKJ PDBsum 4WQ4 http://www.ebi.ac.uk/pdbsum/4WQ4 PDBsum 4WQ5 http://www.ebi.ac.uk/pdbsum/4WQ5 PDBsum 4YDU http://www.ebi.ac.uk/pdbsum/4YDU PSORT swissprot:TSAB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TSAB_ECOLI PSORT-B swissprot:TSAB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TSAB_ECOLI PSORT2 swissprot:TSAB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TSAB_ECOLI Pfam PF00814 http://pfam.xfam.org/family/PF00814 Phobius swissprot:TSAB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TSAB_ECOLI PhylomeDB P76256 http://phylomedb.org/?seqid=P76256 ProteinModelPortal P76256 http://www.proteinmodelportal.org/query/uniprot/P76256 PubMed 16511176 http://www.ncbi.nlm.nih.gov/pubmed/16511176 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19376873 http://www.ncbi.nlm.nih.gov/pubmed/19376873 PubMed 20701780 http://www.ncbi.nlm.nih.gov/pubmed/20701780 PubMed 22378793 http://www.ncbi.nlm.nih.gov/pubmed/22378793 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416321 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416321 RefSeq WP_001220966 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001220966 SMR P76256 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76256 STRING 511145.b1807 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1807&targetmode=cogs STRING COG1214 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1214&targetmode=cogs TIGRFAMs TIGR03725 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03725 UniProtKB TSAB_ECOLI http://www.uniprot.org/uniprot/TSAB_ECOLI UniProtKB-AC P76256 http://www.uniprot.org/uniprot/P76256 charge swissprot:TSAB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TSAB_ECOLI eggNOG COG1214 http://eggnogapi.embl.de/nog_data/html/tree/COG1214 eggNOG ENOG41072GX http://eggnogapi.embl.de/nog_data/html/tree/ENOG41072GX epestfind swissprot:TSAB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TSAB_ECOLI garnier swissprot:TSAB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TSAB_ECOLI helixturnhelix swissprot:TSAB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TSAB_ECOLI hmoment swissprot:TSAB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TSAB_ECOLI iep swissprot:TSAB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TSAB_ECOLI inforesidue swissprot:TSAB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TSAB_ECOLI octanol swissprot:TSAB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TSAB_ECOLI pepcoil swissprot:TSAB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TSAB_ECOLI pepdigest swissprot:TSAB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TSAB_ECOLI pepinfo swissprot:TSAB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TSAB_ECOLI pepnet swissprot:TSAB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TSAB_ECOLI pepstats swissprot:TSAB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TSAB_ECOLI pepwheel swissprot:TSAB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TSAB_ECOLI pepwindow swissprot:TSAB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TSAB_ECOLI sigcleave swissprot:TSAB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TSAB_ECOLI ## Database ID URL or Descriptions # BioGrid 4259360 5 # CDD cd06261 TM_PBP2 # EcoGene EG12038 yejB # FUNCTION YEJB_ECOLI Probably part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; ISS:EcoCyc. # GO_function GO:0022857 transmembrane transporter activity; IBA:GO_Central. # GO_function GO:0042626 ATPase activity, coupled to transmembrane movement of substances; ISS:EcoCyc. # GO_process GO:0042884 microcin transport; IMP:EcoCyc. # GO_process GO:0055085 transmembrane transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # Gene3D 1.10.3720.10 -; 1. # InterPro IPR000515 MetI-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00349 Microcin C transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism YEJB_ECOLI Escherichia coli (strain K12) # PATRIC 32119711 VBIEscCol129921_2266 # PIR A64987 A64987 # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEJB_ECOLI Inner membrane ABC transporter permease protein YejB # RefSeq NP_416683 NC_000913.3 # RefSeq WP_000501604 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA16376.1; Type=Frameshift; Positions=126; Evidence={ECO 0000305}; # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION YEJB_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF161098 SSF161098 # eggNOG COG4174 LUCA # eggNOG ENOG4108I5X Bacteria BLAST swissprot:YEJB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEJB_ECOLI BioCyc ECOL316407:JW2166-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2166-MONOMER BioCyc EcoCyc:YEJB-MONOMER http://biocyc.org/getid?id=EcoCyc:YEJB-MONOMER COG COG4174 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4174 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00008 http://www.ebi.ac.uk/ena/data/view/U00008 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1973 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1973 EcoGene EG12038 http://www.ecogene.org/geneInfo.php?eg_id=EG12038 EnsemblBacteria AAC75239 http://www.ensemblgenomes.org/id/AAC75239 EnsemblBacteria AAC75239 http://www.ensemblgenomes.org/id/AAC75239 EnsemblBacteria BAA15986 http://www.ensemblgenomes.org/id/BAA15986 EnsemblBacteria BAA15986 http://www.ensemblgenomes.org/id/BAA15986 EnsemblBacteria BAA15986 http://www.ensemblgenomes.org/id/BAA15986 EnsemblBacteria b2178 http://www.ensemblgenomes.org/id/b2178 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GO_function GO:0042626 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042626 GO_process GO:0042884 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042884 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 946679 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946679 HOGENOM HOG000170244 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000170244&db=HOGENOM6 InParanoid P0AFU0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFU0 InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2166 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2166 KEGG_Gene eco:b2178 http://www.genome.jp/dbget-bin/www_bget?eco:b2178 KEGG_Orthology KO:K13894 http://www.genome.jp/dbget-bin/www_bget?KO:K13894 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA VRFDFGN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VRFDFGN PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:YEJB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEJB_ECOLI PSORT-B swissprot:YEJB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEJB_ECOLI PSORT2 swissprot:YEJB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEJB_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Phobius swissprot:YEJB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEJB_ECOLI PhylomeDB P0AFU0 http://phylomedb.org/?seqid=P0AFU0 ProteinModelPortal P0AFU0 http://www.proteinmodelportal.org/query/uniprot/P0AFU0 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416683 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416683 RefSeq WP_000501604 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000501604 STRING 511145.b2178 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2178&targetmode=cogs STRING COG4174 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4174&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 UniProtKB YEJB_ECOLI http://www.uniprot.org/uniprot/YEJB_ECOLI UniProtKB-AC P0AFU0 http://www.uniprot.org/uniprot/P0AFU0 charge swissprot:YEJB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEJB_ECOLI eggNOG COG4174 http://eggnogapi.embl.de/nog_data/html/tree/COG4174 eggNOG ENOG4108I5X http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108I5X epestfind swissprot:YEJB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEJB_ECOLI garnier swissprot:YEJB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEJB_ECOLI helixturnhelix swissprot:YEJB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEJB_ECOLI hmoment swissprot:YEJB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEJB_ECOLI iep swissprot:YEJB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEJB_ECOLI inforesidue swissprot:YEJB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEJB_ECOLI octanol swissprot:YEJB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEJB_ECOLI pepcoil swissprot:YEJB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEJB_ECOLI pepdigest swissprot:YEJB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEJB_ECOLI pepinfo swissprot:YEJB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEJB_ECOLI pepnet swissprot:YEJB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEJB_ECOLI pepstats swissprot:YEJB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEJB_ECOLI pepwheel swissprot:YEJB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEJB_ECOLI pepwindow swissprot:YEJB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEJB_ECOLI sigcleave swissprot:YEJB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEJB_ECOLI ## Database ID URL or Descriptions # AltName Branch migration protein RadA {ECO:0000303|PubMed 26845522} # AltName DNA repair protein Sms {ECO:0000303|PubMed 1327967} # BioGrid 4262780 144 # DISRUPTION PHENOTYPE RADA_ECOLI Increased sensitivity to methyl methanesulfonate, mitomycin C, phleomycin (PubMed 1327967, PubMed 12446634). Has a modest defect in RecA-mediated conjugational DNA recombination; double radA-radD mutants have wild-type levels (PubMed 25425430, PubMed 12446634). 10- to 1000- fold decrease in survival after ionising irradiation (IR) (PubMed 25049088, PubMed 25425430). Double radA-radD deletions have nearly 10(6)-fold lower survival against IR and the double mutant is more severely affected by UV radiation than either of the single mutants alone. The single mutation is more sensitive to dsDNA breaks induced by ciprofloxacin (CFX), the double radA-radD mutant is inviable upon CFX treatment; the SOS response is slightly induced in the single and more induced in the double mutant (PubMed 25425430). Another group showed very slight sensitivity to CFX, UV and azidothymidine (AZT) in single deletion mutants, a radA-recG deletion is extremely sensitive to CFX and AZT, less so to UV. The SOS response is induced in the radA-recG double mutant, indicating spontaneous DNA damage. AZT sensitivity is suppressed by further recA or recF deletions, suggesting AZT- induced DNA gaps are processed into lethal intermediates in a RecA-dependent fashion mediated by RecF. RuvAB suppresses UV, CFX and AZT sensitivity to vaarying degrees. Similarly, radA-uvrD double deletions are also more sensitive to UV, CFX and AZT. Adding a recF mutation almost completely suppresses AZT and partially suppresses UV and CFX sensitivity, suggesting RadA processes a class of intermediates that accumulates in uvrD mutants (PubMed 25484163). {ECO 0000269|PubMed 12446634, ECO 0000269|PubMed 1327967, ECO 0000269|PubMed 25049088, ECO 0000269|PubMed 25425430, ECO 0000269|PubMed 25484163}. # DOMAIN RADA_ECOLI Has a putative N-terminal zinc-finger, a region with homology to RecA with ATPase motifs including the RadA KNRFG motif (approximately residues 60-290), while the C-terminus is homologous to Lon protease (from about residue 290 to the end, the ribosomal S5 domain). In this organism the Lon protease active site Ser-372 is conserved, but not all other bacteria encode Ser at this position (PubMed 1327967, PubMed 8759876). Mutation of Ser-372 has no discernible effect on RadA function, suggesting RadA is not a protease (PubMed 25484163). {ECO 0000255|HAMAP- Rule MF_01498, ECO 0000269|PubMed 25484163, ECO 0000305|PubMed 1327967, ECO 0000305|PubMed 8759876}. # EcoGene EG11296 radA # FUNCTION RADA_ECOLI DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function (PubMed 26845522). Genetic experiments involving combination of radA mutations with mutations in recA, recB, recG, recJ, recQ, ruvA and ruvC show it plays a role in recombination and recombinational repair, probably involving stabilizing or processing branched DNA or blocked replication forks. Is genetically synergistic to RecG and RuvABC (PubMed 12446634, PubMed 25484163). May be involved in recovery of genetic rearrangements during replication fork breakdown (PubMed 16904387). In combination with RadD is important in recovery from double-strand DNA breaks (DSB) (PubMed 25425430). {ECO 0000269|PubMed 12446634, ECO 0000269|PubMed 16904387, ECO 0000269|PubMed 25425430, ECO 0000269|PubMed 25484163, ECO 0000269|PubMed 26845522}. # GO_function GO:0003684 damaged DNA binding; IEA:InterPro. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008094 DNA-dependent ATPase activity; IEA:InterPro. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0000725 recombinational repair; IMP:EcoCyc. # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # Gene3D 3.30.230.10 -; 1. # Gene3D 3.40.50.300 -; 1. # HAMAP MF_01498 RadA_bact # INDUCTION Part of the serB-radA operon (PubMed:1327967). {ECO 0000269|PubMed:1327967}. # IntAct P24554 5 # InterPro IPR003593 AAA+_ATPase # InterPro IPR004504 DNA_repair_RadA # InterPro IPR014721 Ribosomal_S5_D2-typ_fold_subgr # InterPro IPR020568 Ribosomal_S5_D2-typ_fold # InterPro IPR020588 RecA_ATP-bd # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko03400 DNA repair and recombination proteins # Organism RADA_ECOLI Escherichia coli (strain K12) # PATRIC 32124394 VBIEscCol129921_4537 # PIR JC1417 JC1417 # PROSITE PS50162 RECA_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RADA_ECOLI DNA repair protein RadA {ECO 0000255|HAMAP-Rule MF_01498, ECO 0000303|PubMed 6754650} # RefSeq NP_418806 NC_000913.3 # RefSeq WP_001029687 NZ_LN832404.1 # SIMILARITY Belongs to the RecA family. RadA subfamily. {ECO:0000255|HAMAP-Rule MF_01498}. # SMART SM00382 AAA # SUPFAM SSF52540 SSF52540 # SUPFAM SSF54211 SSF54211; 2 # TIGRFAMs TIGR00416 sms # eggNOG COG1066 LUCA # eggNOG ENOG4105DNJ Bacteria BLAST swissprot:RADA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RADA_ECOLI BioCyc ECOL316407:JW4352-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4352-MONOMER BioCyc EcoCyc:EG11296-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11296-MONOMER COG COG1066 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1066 DIP DIP-10635N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10635N DOI 10.1016/0378-1119(92)90002-7 http://dx.doi.org/10.1016/0378-1119(92)90002-7 DOI 10.1016/j.dnarep.2006.06.008 http://dx.doi.org/10.1016/j.dnarep.2006.06.008 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1080/09553008214551251 http://dx.doi.org/10.1080/09553008214551251 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1111/mmi.12885 http://dx.doi.org/10.1111/mmi.12885 DOI 10.1111/mmi.12899 http://dx.doi.org/10.1111/mmi.12899 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01589-14 http://dx.doi.org/10.1128/JB.01589-14 DOI 10.1128/JB.184.24.6836-6844.2002 http://dx.doi.org/10.1128/JB.184.24.6836-6844.2002 DOI 10.7554/eLife.10807 http://dx.doi.org/10.7554/eLife.10807 EC_number EC:3.6.4.- {ECO:0000269|PubMed:26845522} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.4.- {ECO:0000269|PubMed:26845522} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL U59449 http://www.ebi.ac.uk/ena/data/view/U59449 EMBL X63155 http://www.ebi.ac.uk/ena/data/view/X63155 ENZYME 3.6.4.- {ECO:0000269|PubMed:26845522} http://enzyme.expasy.org/EC/3.6.4.- {ECO:0000269|PubMed:26845522} EchoBASE EB1273 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1273 EcoGene EG11296 http://www.ecogene.org/geneInfo.php?eg_id=EG11296 EnsemblBacteria AAC77342 http://www.ensemblgenomes.org/id/AAC77342 EnsemblBacteria AAC77342 http://www.ensemblgenomes.org/id/AAC77342 EnsemblBacteria BAE78378 http://www.ensemblgenomes.org/id/BAE78378 EnsemblBacteria BAE78378 http://www.ensemblgenomes.org/id/BAE78378 EnsemblBacteria BAE78378 http://www.ensemblgenomes.org/id/BAE78378 EnsemblBacteria b4389 http://www.ensemblgenomes.org/id/b4389 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003684 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003684 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008094 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008094 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0000725 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000725 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.30.230.10 http://www.cathdb.info/version/latest/superfamily/3.30.230.10 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948912 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948912 HAMAP MF_01498 http://hamap.expasy.org/unirule/MF_01498 HOGENOM HOG000218329 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218329&db=HOGENOM6 InParanoid P24554 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P24554 IntAct P24554 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P24554* IntEnz 3.6.4.- {ECO:0000269|PubMed:26845522} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.4.- {ECO:0000269|PubMed:26845522} InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR004504 http://www.ebi.ac.uk/interpro/entry/IPR004504 InterPro IPR014721 http://www.ebi.ac.uk/interpro/entry/IPR014721 InterPro IPR020568 http://www.ebi.ac.uk/interpro/entry/IPR020568 InterPro IPR020588 http://www.ebi.ac.uk/interpro/entry/IPR020588 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW4352 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4352 KEGG_Gene eco:b4389 http://www.genome.jp/dbget-bin/www_bget?eco:b4389 KEGG_Orthology KO:K04485 http://www.genome.jp/dbget-bin/www_bget?KO:K04485 OMA EVGCFEL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EVGCFEL PROSITE PS50162 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50162 PSORT swissprot:RADA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RADA_ECOLI PSORT-B swissprot:RADA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RADA_ECOLI PSORT2 swissprot:RADA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RADA_ECOLI Phobius swissprot:RADA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RADA_ECOLI PhylomeDB P24554 http://phylomedb.org/?seqid=P24554 ProteinModelPortal P24554 http://www.proteinmodelportal.org/query/uniprot/P24554 PubMed 12446634 http://www.ncbi.nlm.nih.gov/pubmed/12446634 PubMed 1327967 http://www.ncbi.nlm.nih.gov/pubmed/1327967 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16904387 http://www.ncbi.nlm.nih.gov/pubmed/16904387 PubMed 25049088 http://www.ncbi.nlm.nih.gov/pubmed/25049088 PubMed 25425430 http://www.ncbi.nlm.nih.gov/pubmed/25425430 PubMed 25484163 http://www.ncbi.nlm.nih.gov/pubmed/25484163 PubMed 26845522 http://www.ncbi.nlm.nih.gov/pubmed/26845522 PubMed 6754650 http://www.ncbi.nlm.nih.gov/pubmed/6754650 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8759876 http://www.ncbi.nlm.nih.gov/pubmed/8759876 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418806 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418806 RefSeq WP_001029687 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001029687 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P24554 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P24554 STRING 511145.b4389 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4389&targetmode=cogs STRING COG1066 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1066&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SUPFAM SSF54211 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54211 TIGRFAMs TIGR00416 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00416 UniProtKB RADA_ECOLI http://www.uniprot.org/uniprot/RADA_ECOLI UniProtKB-AC P24554 http://www.uniprot.org/uniprot/P24554 charge swissprot:RADA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RADA_ECOLI eggNOG COG1066 http://eggnogapi.embl.de/nog_data/html/tree/COG1066 eggNOG ENOG4105DNJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DNJ epestfind swissprot:RADA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RADA_ECOLI garnier swissprot:RADA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RADA_ECOLI helixturnhelix swissprot:RADA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RADA_ECOLI hmoment swissprot:RADA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RADA_ECOLI iep swissprot:RADA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RADA_ECOLI inforesidue swissprot:RADA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RADA_ECOLI octanol swissprot:RADA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RADA_ECOLI pepcoil swissprot:RADA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RADA_ECOLI pepdigest swissprot:RADA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RADA_ECOLI pepinfo swissprot:RADA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RADA_ECOLI pepnet swissprot:RADA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RADA_ECOLI pepstats swissprot:RADA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RADA_ECOLI pepwheel swissprot:RADA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RADA_ECOLI pepwindow swissprot:RADA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RADA_ECOLI sigcleave swissprot:RADA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RADA_ECOLI ## Database ID URL or Descriptions # AltName SERC_ECOLI Phosphohydroxythreonine aminotransferase # BIOPHYSICOCHEMICAL PROPERTIES SERC_ECOLI Kinetic parameters KM=15 uM for 3-phosphonooxypyruvate {ECO 0000269|PubMed 8706854}; KM=17 uM for O(3)-phospho-L-serine {ECO 0000269|PubMed 8706854}; KM=110 uM for 4-phosphonooxy-L-threonine {ECO 0000269|PubMed 8706854}; Vmax=45 nmol/sec/mg enzyme with 3-phosphonooxypyruvate as substrate {ECO 0000269|PubMed 8706854}; Vmax=9.9 nmol/sec/mg enzyme with O(3)-phospho-L-serine as substrate {ECO 0000269|PubMed 8706854}; Vmax=3.8 nmol/sec/mg enzyme with 4-phosphonooxy-L-threonine as substrate {ECO 0000269|PubMed 8706854}; Note=No activity could be observed with non-phosphorylated substrates.; pH dependence Optimum pH is 7.5-8.8. {ECO 0000269|PubMed 8706854}; # BioGrid 4260006 18 # CATALYTIC ACTIVITY 4-phosphonooxy-L-threonine + 2-oxoglutarate = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate. {ECO:0000269|PubMed 8706854}. # CATALYTIC ACTIVITY O-phospho-L-serine + 2-oxoglutarate = 3- phosphonooxypyruvate + L-glutamate. {ECO:0000269|PubMed 8706854}. # CDD cd00611 PSAT_like # COFACTOR SERC_ECOLI Name=pyridoxal 5'-phosphate; Xref=ChEBI CHEBI 597326; Evidence={ECO 0000269|PubMed 8706854}; Note=Binds 1 pyridoxal phosphate per subunit. {ECO 0000269|PubMed 8706854}; # EcoGene EG10946 serC # FUNCTION SERC_ECOLI Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. Is involved in both pyridoxine and serine biosynthesis. {ECO 0000269|PubMed 2121717, ECO 0000269|PubMed 8706854}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0030170 pyridoxal phosphate binding; IDA:EcoCyc. # GO_function SERC_ECOLI GO 0004648 O-phospho-L-serine 2-oxoglutarate aminotransferase activity; IDA EcoCyc. # GO_process GO:0006563 L-serine metabolic process; IGI:UniProtKB. # GO_process GO:0006564 L-serine biosynthetic process; IMP:EcoCyc. # GO_process GO:0008615 pyridoxine biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0033359 lysine biosynthetic process via diaminopimelate and N-succinyl-2-amino-6-ketopimelate; IGI:EcoCyc. # GO_process GO:0042823 pyridoxal phosphate biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.640.10 -; 1. # Gene3D 3.90.1150.10 -; 1. # HAMAP MF_00160 SerC_aminotrans_5 # IntAct P23721 9 # InterPro IPR000192 Aminotrans_V_dom # InterPro IPR015421 PyrdxlP-dep_Trfase_major_sub1 # InterPro IPR015422 PyrdxlP-dep_Trfase_major_sub2 # InterPro IPR015424 PyrdxlP-dep_Trfase # InterPro IPR020578 Aminotrans_V_PyrdxlP_BS # InterPro IPR022278 Pser_aminoTfrase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01007 Amino acid related enzymes # KEGG_Pathway ko00260 Glycine, serine and threonine metabolism # KEGG_Pathway ko00680 Methane metabolism # KEGG_Pathway ko00750 Vitamin B6 metabolism # Organism SERC_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3. {ECO 0000269|PubMed:2121717}. # PATHWAY Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4- phosphate: step 3/5. {ECO 0000269|PubMed:2121717}. # PATRIC 32117027 VBIEscCol129921_0938 # PDB 1BJN X-ray; 2.30 A; A/B=3-362 # PDB 1BJO X-ray; 2.80 A; A/B=3-362 # PIR B64830 B64830 # PIRSF PIRSF000525 SerC # PROSITE PS00595 AA_TRANSFER_CLASS_5 # Pfam PF00266 Aminotran_5 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SERC_ECOLI Phosphoserine aminotransferase # RefSeq NP_415427 NC_000913.3 # RefSeq WP_000057138 NZ_LN832404.1 # SIMILARITY Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION SERC_ECOLI Cytoplasm. # SUBUNIT Homodimer. {ECO:0000269|PubMed 10024454}. # SUPFAM SSF53383 SSF53383 # TIGRFAMs TIGR01364 serC_1 # UniPathway UPA00135 UER00197 # UniPathway UPA00244 UER00311 # eggNOG COG1932 LUCA # eggNOG ENOG4107QM1 Bacteria BLAST swissprot:SERC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SERC_ECOLI BioCyc ECOL316407:JW0890-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0890-MONOMER BioCyc EcoCyc:PSERTRANSAM-MONOMER http://biocyc.org/getid?id=EcoCyc:PSERTRANSAM-MONOMER BioCyc MetaCyc:PSERTRANSAM-MONOMER http://biocyc.org/getid?id=MetaCyc:PSERTRANSAM-MONOMER COG COG1932 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1932 DIP DIP-2896N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-2896N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1998.2506 http://dx.doi.org/10.1006/jmbi.1998.2506 DOI 10.1016/0014-5793(96)00652-7 http://dx.doi.org/10.1016/0014-5793(96)00652-7 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2340049 http://dx.doi.org/10.1042/bj2340049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/17.20.8379 http://dx.doi.org/10.1093/nar/17.20.8379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.6.1.52 http://www.genome.jp/dbget-bin/www_bget?EC:2.6.1.52 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.6.1.52 http://enzyme.expasy.org/EC/2.6.1.52 EchoBASE EB0939 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0939 EcoGene EG10946 http://www.ecogene.org/geneInfo.php?eg_id=EG10946 EnsemblBacteria AAC73993 http://www.ensemblgenomes.org/id/AAC73993 EnsemblBacteria AAC73993 http://www.ensemblgenomes.org/id/AAC73993 EnsemblBacteria BAA35642 http://www.ensemblgenomes.org/id/BAA35642 EnsemblBacteria BAA35642 http://www.ensemblgenomes.org/id/BAA35642 EnsemblBacteria BAA35642 http://www.ensemblgenomes.org/id/BAA35642 EnsemblBacteria b0907 http://www.ensemblgenomes.org/id/b0907 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004648 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004648 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_process GO:0006563 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006563 GO_process GO:0006564 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006564 GO_process GO:0008615 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008615 GO_process GO:0033359 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033359 GO_process GO:0042823 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042823 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.640.10 http://www.cathdb.info/version/latest/superfamily/3.40.640.10 Gene3D 3.90.1150.10 http://www.cathdb.info/version/latest/superfamily/3.90.1150.10 GeneID 945527 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945527 HAMAP MF_00160 http://hamap.expasy.org/unirule/MF_00160 HOGENOM HOG000088965 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000088965&db=HOGENOM6 InParanoid P23721 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23721 IntAct P23721 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P23721* IntEnz 2.6.1.52 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.6.1.52 InterPro IPR000192 http://www.ebi.ac.uk/interpro/entry/IPR000192 InterPro IPR015421 http://www.ebi.ac.uk/interpro/entry/IPR015421 InterPro IPR015422 http://www.ebi.ac.uk/interpro/entry/IPR015422 InterPro IPR015424 http://www.ebi.ac.uk/interpro/entry/IPR015424 InterPro IPR020578 http://www.ebi.ac.uk/interpro/entry/IPR020578 InterPro IPR022278 http://www.ebi.ac.uk/interpro/entry/IPR022278 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Gene ecj:JW0890 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0890 KEGG_Gene eco:b0907 http://www.genome.jp/dbget-bin/www_bget?eco:b0907 KEGG_Orthology KO:K00831 http://www.genome.jp/dbget-bin/www_bget?KO:K00831 KEGG_Pathway ko00260 http://www.genome.jp/kegg-bin/show_pathway?ko00260 KEGG_Pathway ko00680 http://www.genome.jp/kegg-bin/show_pathway?ko00680 KEGG_Pathway ko00750 http://www.genome.jp/kegg-bin/show_pathway?ko00750 KEGG_Reaction rn:R04173 http://www.genome.jp/dbget-bin/www_bget?rn:R04173 KEGG_Reaction rn:R05085 http://www.genome.jp/dbget-bin/www_bget?rn:R05085 MINT MINT-1249760 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1249760 OMA GAQKNMG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GAQKNMG PDB 1BJN http://www.ebi.ac.uk/pdbe-srv/view/entry/1BJN PDB 1BJO http://www.ebi.ac.uk/pdbe-srv/view/entry/1BJO PDBsum 1BJN http://www.ebi.ac.uk/pdbsum/1BJN PDBsum 1BJO http://www.ebi.ac.uk/pdbsum/1BJO PROSITE PS00595 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00595 PSORT swissprot:SERC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SERC_ECOLI PSORT-B swissprot:SERC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SERC_ECOLI PSORT2 swissprot:SERC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SERC_ECOLI Pfam PF00266 http://pfam.xfam.org/family/PF00266 Phobius swissprot:SERC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SERC_ECOLI PhylomeDB P23721 http://phylomedb.org/?seqid=P23721 ProteinModelPortal P23721 http://www.proteinmodelportal.org/query/uniprot/P23721 PubMed 10024454 http://www.ncbi.nlm.nih.gov/pubmed/10024454 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2121717 http://www.ncbi.nlm.nih.gov/pubmed/2121717 PubMed 2682527 http://www.ncbi.nlm.nih.gov/pubmed/2682527 PubMed 3518706 http://www.ncbi.nlm.nih.gov/pubmed/3518706 PubMed 8706854 http://www.ncbi.nlm.nih.gov/pubmed/8706854 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_415427 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415427 RefSeq WP_000057138 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000057138 SMR P23721 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P23721 STRING 511145.b0907 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0907&targetmode=cogs STRING COG1932 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1932&targetmode=cogs SUPFAM SSF53383 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53383 SWISS-2DPAGE P23721 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P23721 TIGRFAMs TIGR01364 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01364 UniProtKB SERC_ECOLI http://www.uniprot.org/uniprot/SERC_ECOLI UniProtKB-AC P23721 http://www.uniprot.org/uniprot/P23721 charge swissprot:SERC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SERC_ECOLI eggNOG COG1932 http://eggnogapi.embl.de/nog_data/html/tree/COG1932 eggNOG ENOG4107QM1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QM1 epestfind swissprot:SERC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SERC_ECOLI garnier swissprot:SERC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SERC_ECOLI helixturnhelix swissprot:SERC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SERC_ECOLI hmoment swissprot:SERC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SERC_ECOLI iep swissprot:SERC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SERC_ECOLI inforesidue swissprot:SERC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SERC_ECOLI octanol swissprot:SERC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SERC_ECOLI pepcoil swissprot:SERC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SERC_ECOLI pepdigest swissprot:SERC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SERC_ECOLI pepinfo swissprot:SERC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SERC_ECOLI pepnet swissprot:SERC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SERC_ECOLI pepstats swissprot:SERC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SERC_ECOLI pepwheel swissprot:SERC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SERC_ECOLI pepwindow swissprot:SERC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SERC_ECOLI sigcleave swissprot:SERC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SERC_ECOLI ## Database ID URL or Descriptions # AltName ABGT_ECOLI PABA-GLU transport protein # BioGrid 4260156 183 # DISRUPTION PHENOTYPE Cells lacking this gene loss the p- aminobenzoyl-glutamate utilization phenotype. {ECO:0000269|PubMed 9829935}. # ENZYME REGULATION Completely inhibited by 100 nM of sodium azide and slightly inhibited by 100 mM of potassium fluoride. {ECO:0000269|PubMed 17307853}. # EcoGene EG12853 abgT # FUNCTION ABGT_ECOLI Essential for aminobenzoyl-glutamate utilization. It catalyzes the concentration-dependent uptake of p-aminobenzoyl- glutamate (PABA-GLU) into the cell and allows accumulation of PABA-GLU to a concentration enabling AbgAB to catalyze cleavage into p-aminobenzoate and glutamate. It seems also to increase the sensitivity to low levels of aminobenzoyl-glutamate. May actually serve physiologically as a transporter for some other molecule, perhaps a dipeptide, and that it transports p-aminobenzoyl- glutamate as a secondary activity. The physiological role of abgABT should be clarified. {ECO 0000269|PubMed 17307853, ECO 0000269|PubMed 20190044}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015291 secondary active transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0015558 p-aminobenzoyl-glutamate uptake transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0006865 amino acid transport; IEA:UniProtKB-KW. # GO_process GO:0015814 p-aminobenzoyl-glutamate transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # INDUCTION Could be transcriptionally regulated by AbgR. {ECO:0000269|PubMed 9829935}. # InterPro IPR004697 AbgT # InterPro IPR011540 AbgT_Proteobac # MISCELLANEOUS It is suggested that in wild-type strain abgT would normally be cryptic or not expressed under conditions of growth on minimal medium. Altering the expression of abgT from its wild-type context appears to be the mechanism for obtaining the growth phenotype (PubMed:9829935). {ECO 0000305|PubMed:9829935}. # Organism ABGT_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30282:SF0 PTHR30282:SF0 # PATRIC 32117948 VBIEscCol129921_1394 # PIR C64883 C64883 # Pfam PF03806 ABG_transport # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ABGT_ECOLI p-aminobenzoyl-glutamate transport protein # RefSeq NP_415852 NC_000913.3 # SUBCELLULAR LOCATION ABGT_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # TCDB 2.A.68.1 the p-aminobenzoyl-glutamate transporter (abgt) family # TIGRFAMs TIGR00819 ydaH # eggNOG COG2978 LUCA # eggNOG ENOG4105CFC Bacteria BLAST swissprot:ABGT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ABGT_ECOLI BioCyc ECOL316407:JW5822-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5822-MONOMER BioCyc EcoCyc:ABGT-MONOMER http://biocyc.org/getid?id=EcoCyc:ABGT-MONOMER BioCyc MetaCyc:ABGT-MONOMER http://biocyc.org/getid?id=MetaCyc:ABGT-MONOMER COG COG2978 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2978 DIP DIP-9031N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9031N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/15.22.9177 http://dx.doi.org/10.1093/nar/15.22.9177 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01362-09 http://dx.doi.org/10.1128/JB.01362-09 DOI 10.1128/JB.01940-06 http://dx.doi.org/10.1128/JB.01940-06 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL Y00495 http://www.ebi.ac.uk/ena/data/view/Y00495 EchoBASE EB2697 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2697 EcoGene EG12853 http://www.ecogene.org/geneInfo.php?eg_id=EG12853 EnsemblBacteria AAC74418 http://www.ensemblgenomes.org/id/AAC74418 EnsemblBacteria AAC74418 http://www.ensemblgenomes.org/id/AAC74418 EnsemblBacteria BAA14929 http://www.ensemblgenomes.org/id/BAA14929 EnsemblBacteria BAA14929 http://www.ensemblgenomes.org/id/BAA14929 EnsemblBacteria BAA14929 http://www.ensemblgenomes.org/id/BAA14929 EnsemblBacteria b1336 http://www.ensemblgenomes.org/id/b1336 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015291 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015291 GO_function GO:0015558 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015558 GO_process GO:0006865 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865 GO_process GO:0015814 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015814 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 945912 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945912 HOGENOM HOG000285565 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000285565&db=HOGENOM6 InParanoid P46133 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P46133 IntAct P46133 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P46133* InterPro IPR004697 http://www.ebi.ac.uk/interpro/entry/IPR004697 InterPro IPR011540 http://www.ebi.ac.uk/interpro/entry/IPR011540 KEGG_Gene ecj:JW5822 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5822 KEGG_Gene eco:b1336 http://www.genome.jp/dbget-bin/www_bget?eco:b1336 KEGG_Orthology KO:K12942 http://www.genome.jp/dbget-bin/www_bget?KO:K12942 OMA PFIQGIV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PFIQGIV PANTHER PTHR30282:SF0 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30282:SF0 PSORT swissprot:ABGT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ABGT_ECOLI PSORT-B swissprot:ABGT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ABGT_ECOLI PSORT2 swissprot:ABGT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ABGT_ECOLI Pfam PF03806 http://pfam.xfam.org/family/PF03806 Phobius swissprot:ABGT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ABGT_ECOLI PhylomeDB P46133 http://phylomedb.org/?seqid=P46133 ProteinModelPortal P46133 http://www.proteinmodelportal.org/query/uniprot/P46133 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17307853 http://www.ncbi.nlm.nih.gov/pubmed/17307853 PubMed 20190044 http://www.ncbi.nlm.nih.gov/pubmed/20190044 PubMed 2825131 http://www.ncbi.nlm.nih.gov/pubmed/2825131 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9829935 http://www.ncbi.nlm.nih.gov/pubmed/9829935 RefSeq NP_415852 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415852 STRING 511145.b1336 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1336&targetmode=cogs STRING COG2978 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2978&targetmode=cogs TCDB 2.A.68.1 http://www.tcdb.org/search/result.php?tc=2.A.68.1 TIGRFAMs TIGR00819 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00819 UniProtKB ABGT_ECOLI http://www.uniprot.org/uniprot/ABGT_ECOLI UniProtKB-AC P46133 http://www.uniprot.org/uniprot/P46133 charge swissprot:ABGT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ABGT_ECOLI eggNOG COG2978 http://eggnogapi.embl.de/nog_data/html/tree/COG2978 eggNOG ENOG4105CFC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CFC epestfind swissprot:ABGT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ABGT_ECOLI garnier swissprot:ABGT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ABGT_ECOLI helixturnhelix swissprot:ABGT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ABGT_ECOLI hmoment swissprot:ABGT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ABGT_ECOLI iep swissprot:ABGT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ABGT_ECOLI inforesidue swissprot:ABGT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ABGT_ECOLI octanol swissprot:ABGT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ABGT_ECOLI pepcoil swissprot:ABGT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ABGT_ECOLI pepdigest swissprot:ABGT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ABGT_ECOLI pepinfo swissprot:ABGT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ABGT_ECOLI pepnet swissprot:ABGT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ABGT_ECOLI pepstats swissprot:ABGT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ABGT_ECOLI pepwheel swissprot:ABGT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ABGT_ECOLI pepwindow swissprot:ABGT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ABGT_ECOLI sigcleave swissprot:ABGT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ABGT_ECOLI ## Database ID URL or Descriptions # BioGrid 4260376 10 # EcoGene EG14013 flhE # FUNCTION FLHE_ECOLI Not essential for flagellar formation and function. # GO_component GO:0009288 bacterial-type flagellum; IMP:EcoCyc. # GO_process GO:0044781 bacterial-type flagellum organization; IMP:EcoCyc. # GOslim_component GO:0043226 organelle # GOslim_process GO:0008150 biological_process # IntAct P76297 3 # InterPro IPR009420 FlhE # KEGG_Brite ko02035 Bacterial motility proteins # Organism FLHE_ECOLI Escherichia coli (strain K12) # PATRIC 32119081 VBIEscCol129921_1958 # PIR F64950 F64950 # Pfam PF06366 FlhE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FLHE_ECOLI Flagellar protein FlhE # RefSeq NP_416392 NC_000913.3 # RefSeq WP_001259583 NZ_LN832404.1 # eggNOG ENOG4105W13 Bacteria # eggNOG ENOG41122XP LUCA BLAST swissprot:FLHE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLHE_ECOLI BioCyc ECOL316407:JW1867-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1867-MONOMER BioCyc EcoCyc:G7027-MONOMER http://biocyc.org/getid?id=EcoCyc:G7027-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U88319 http://www.ebi.ac.uk/ena/data/view/U88319 EchoBASE EB3769 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3769 EcoGene EG14013 http://www.ecogene.org/geneInfo.php?eg_id=EG14013 EnsemblBacteria AAC74948 http://www.ensemblgenomes.org/id/AAC74948 EnsemblBacteria AAC74948 http://www.ensemblgenomes.org/id/AAC74948 EnsemblBacteria BAA15687 http://www.ensemblgenomes.org/id/BAA15687 EnsemblBacteria BAA15687 http://www.ensemblgenomes.org/id/BAA15687 EnsemblBacteria BAA15687 http://www.ensemblgenomes.org/id/BAA15687 EnsemblBacteria b1878 http://www.ensemblgenomes.org/id/b1878 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009288 GO_process GO:0044781 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044781 GOslim_component GO:0043226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 946094 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946094 HOGENOM HOG000121262 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000121262&db=HOGENOM6 IntAct P76297 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76297* InterPro IPR009420 http://www.ebi.ac.uk/interpro/entry/IPR009420 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW1867 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1867 KEGG_Gene eco:b1878 http://www.genome.jp/dbget-bin/www_bget?eco:b1878 KEGG_Orthology KO:K03516 http://www.genome.jp/dbget-bin/www_bget?KO:K03516 OMA EGAWQAS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EGAWQAS PSORT swissprot:FLHE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLHE_ECOLI PSORT-B swissprot:FLHE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLHE_ECOLI PSORT2 swissprot:FLHE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLHE_ECOLI Pfam PF06366 http://pfam.xfam.org/family/PF06366 Phobius swissprot:FLHE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLHE_ECOLI ProteinModelPortal P76297 http://www.proteinmodelportal.org/query/uniprot/P76297 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416392 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416392 RefSeq WP_001259583 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001259583 SMR P76297 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76297 STRING 511145.b1878 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1878&targetmode=cogs UniProtKB FLHE_ECOLI http://www.uniprot.org/uniprot/FLHE_ECOLI UniProtKB-AC P76297 http://www.uniprot.org/uniprot/P76297 charge swissprot:FLHE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLHE_ECOLI eggNOG ENOG4105W13 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105W13 eggNOG ENOG41122XP http://eggnogapi.embl.de/nog_data/html/tree/ENOG41122XP epestfind swissprot:FLHE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLHE_ECOLI garnier swissprot:FLHE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLHE_ECOLI helixturnhelix swissprot:FLHE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLHE_ECOLI hmoment swissprot:FLHE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLHE_ECOLI iep swissprot:FLHE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLHE_ECOLI inforesidue swissprot:FLHE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLHE_ECOLI octanol swissprot:FLHE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLHE_ECOLI pepcoil swissprot:FLHE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLHE_ECOLI pepdigest swissprot:FLHE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLHE_ECOLI pepinfo swissprot:FLHE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLHE_ECOLI pepnet swissprot:FLHE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLHE_ECOLI pepstats swissprot:FLHE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLHE_ECOLI pepwheel swissprot:FLHE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLHE_ECOLI pepwindow swissprot:FLHE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLHE_ECOLI sigcleave swissprot:FLHE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLHE_ECOLI ## Database ID URL or Descriptions # AltName CYSQ_ECOLI 3'(2'),5-bisphosphonucleoside 3'(2')-phosphohydrolase # AltName CYSQ_ECOLI 3'-phosphoadenosine 5'-phosphate phosphatase # AltName CYSQ_ECOLI DPNPase # BIOPHYSICOCHEMICAL PROPERTIES CYSQ_ECOLI Kinetic parameters KM=1.1 uM for PAP {ECO 0000269|PubMed 10224133}; KM=1.2 mM for Ins(1,4)P2 {ECO 0000269|PubMed 10224133}; # BioGrid 4259304 19 # CATALYTIC ACTIVITY Adenosine 3',5'-bisphosphate + H(2)O = adenosine 5'-phosphate + phosphate. {ECO:0000269|PubMed 10224133}. # CAUTION Was originally thought to be an ammonium transport protein. {ECO:0000305|PubMed 1856684}. # COFACTOR CYSQ_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000305|PubMed 16682444}; # ENZYME REGULATION Inhibited by lithium and calcium. {ECO:0000269|PubMed 16682444}. # EcoGene EG10043 cysQ # FUNCTION CYSQ_ECOLI Converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP. May also convert adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS). Has 10000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2). {ECO 0000269|PubMed 16682444, ECO 0000269|PubMed 7493934}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0008441 3'(2'),5'-bisphosphate nucleotidase activity; IDA:EcoCyc. # GO_process GO:0000103 sulfate assimilation; IMP:EcoCyc. # GO_process GO:0046854 phosphatidylinositol phosphorylation; IEA:InterPro. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # INDUCTION CYSQ_ECOLI Strongly repressed during nitrogen excess. # IntAct P22255 6 # InterPro IPR000760 Inositol_monophosphatase-like # InterPro IPR006240 Bisphos_bac # InterPro IPR020550 Inositol_monophosphatase_CS # InterPro IPR020583 Inositol_monoP_metal-BS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # KEGG_Pathway ko00920 Sulfur metabolism # Organism CYSQ_ECOLI Escherichia coli (strain K12) # PANTHER PTHR20854 PTHR20854 # PATRIC 32124003 VBIEscCol129921_4346 # PIR S56439 S56439 # PROSITE PS00629 IMP_1 # PROSITE PS00630 IMP_2 # Pfam PF00459 Inositol_P # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CYSQ_ECOLI 3'(2'),5'-bisphosphate nucleotidase CysQ # RefSeq NP_418635 NC_000913.3 # RefSeq WP_000886919 NZ_LN832404.1 # SIMILARITY Belongs to the inositol monophosphatase family. {ECO 0000305}. # SUBCELLULAR LOCATION CYSQ_ECOLI Cytoplasm. Cell inner membrane {ECO 0000305}; Peripheral membrane protein {ECO 0000305}; Cytoplasmic side {ECO 0000305}. # TIGRFAMs TIGR01331 bisphos_cysQ # eggNOG COG1218 LUCA # eggNOG ENOG4108RNI Bacteria BLAST swissprot:CYSQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CYSQ_ECOLI BioCyc ECOL316407:JW4172-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4172-MONOMER BioCyc EcoCyc:EG10043-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10043-MONOMER BioCyc MetaCyc:EG10043-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10043-MONOMER COG COG1218 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1218 DIP DIP-9385N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9385N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.270.49.29105 http://dx.doi.org/10.1074/jbc.270.49.29105 DOI 10.1074/jbc.274.19.13619 http://dx.doi.org/10.1074/jbc.274.19.13619 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1093/nar/gkl247 http://dx.doi.org/10.1093/nar/gkl247 DOI 10.1099/00221287-137-4-983 http://dx.doi.org/10.1099/00221287-137-4-983 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.3.7 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.7 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M55170 http://www.ebi.ac.uk/ena/data/view/M55170 EMBL M80795 http://www.ebi.ac.uk/ena/data/view/M80795 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X54008 http://www.ebi.ac.uk/ena/data/view/X54008 ENZYME 3.1.3.7 http://enzyme.expasy.org/EC/3.1.3.7 EchoBASE EB0041 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0041 EcoGene EG10043 http://www.ecogene.org/geneInfo.php?eg_id=EG10043 EnsemblBacteria AAC77171 http://www.ensemblgenomes.org/id/AAC77171 EnsemblBacteria AAC77171 http://www.ensemblgenomes.org/id/AAC77171 EnsemblBacteria BAE78215 http://www.ensemblgenomes.org/id/BAE78215 EnsemblBacteria BAE78215 http://www.ensemblgenomes.org/id/BAE78215 EnsemblBacteria BAE78215 http://www.ensemblgenomes.org/id/BAE78215 EnsemblBacteria b4214 http://www.ensemblgenomes.org/id/b4214 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0008441 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008441 GO_process GO:0000103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000103 GO_process GO:0046854 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046854 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GeneID 948728 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948728 HOGENOM HOG000282237 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000282237&db=HOGENOM6 InParanoid P22255 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P22255 IntAct P22255 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P22255* IntEnz 3.1.3.7 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.7 InterPro IPR000760 http://www.ebi.ac.uk/interpro/entry/IPR000760 InterPro IPR006240 http://www.ebi.ac.uk/interpro/entry/IPR006240 InterPro IPR020550 http://www.ebi.ac.uk/interpro/entry/IPR020550 InterPro IPR020583 http://www.ebi.ac.uk/interpro/entry/IPR020583 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW4172 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4172 KEGG_Gene eco:b4214 http://www.genome.jp/dbget-bin/www_bget?eco:b4214 KEGG_Orthology KO:K01082 http://www.genome.jp/dbget-bin/www_bget?KO:K01082 KEGG_Pathway ko00920 http://www.genome.jp/kegg-bin/show_pathway?ko00920 KEGG_Reaction rn:R00508 http://www.genome.jp/dbget-bin/www_bget?rn:R00508 MINT MINT-1300047 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1300047 OMA AIMQVYN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AIMQVYN PANTHER PTHR20854 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20854 PROSITE PS00629 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00629 PROSITE PS00630 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00630 PSORT swissprot:CYSQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CYSQ_ECOLI PSORT-B swissprot:CYSQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CYSQ_ECOLI PSORT2 swissprot:CYSQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CYSQ_ECOLI Pfam PF00459 http://pfam.xfam.org/family/PF00459 Phobius swissprot:CYSQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CYSQ_ECOLI PhylomeDB P22255 http://phylomedb.org/?seqid=P22255 ProteinModelPortal P22255 http://www.proteinmodelportal.org/query/uniprot/P22255 PubMed 10224133 http://www.ncbi.nlm.nih.gov/pubmed/10224133 PubMed 16682444 http://www.ncbi.nlm.nih.gov/pubmed/16682444 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1729235 http://www.ncbi.nlm.nih.gov/pubmed/1729235 PubMed 1856684 http://www.ncbi.nlm.nih.gov/pubmed/1856684 PubMed 2172762 http://www.ncbi.nlm.nih.gov/pubmed/2172762 PubMed 7493934 http://www.ncbi.nlm.nih.gov/pubmed/7493934 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418635 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418635 RefSeq WP_000886919 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000886919 SMR P22255 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P22255 STRING 511145.b4214 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4214&targetmode=cogs STRING COG1218 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1218&targetmode=cogs TIGRFAMs TIGR01331 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01331 UniProtKB CYSQ_ECOLI http://www.uniprot.org/uniprot/CYSQ_ECOLI UniProtKB-AC P22255 http://www.uniprot.org/uniprot/P22255 charge swissprot:CYSQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CYSQ_ECOLI eggNOG COG1218 http://eggnogapi.embl.de/nog_data/html/tree/COG1218 eggNOG ENOG4108RNI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108RNI epestfind swissprot:CYSQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CYSQ_ECOLI garnier swissprot:CYSQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CYSQ_ECOLI helixturnhelix swissprot:CYSQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CYSQ_ECOLI hmoment swissprot:CYSQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CYSQ_ECOLI iep swissprot:CYSQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CYSQ_ECOLI inforesidue swissprot:CYSQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CYSQ_ECOLI octanol swissprot:CYSQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CYSQ_ECOLI pepcoil swissprot:CYSQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CYSQ_ECOLI pepdigest swissprot:CYSQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CYSQ_ECOLI pepinfo swissprot:CYSQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CYSQ_ECOLI pepnet swissprot:CYSQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CYSQ_ECOLI pepstats swissprot:CYSQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CYSQ_ECOLI pepwheel swissprot:CYSQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CYSQ_ECOLI pepwindow swissprot:CYSQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CYSQ_ECOLI sigcleave swissprot:CYSQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CYSQ_ECOLI ## Database ID URL or Descriptions # AltName MTNN_ECOLI 5'-methylthioadenosine nucleosidase # AltName MTNN_ECOLI P46 # AltName MTNN_ECOLI S-adenosylhomocysteine nucleosidase # BIOPHYSICOCHEMICAL PROPERTIES MTNN_ECOLI Kinetic parameters KM=0.43 uM for 5'-methylthioadenosine (at pH 7 and 37 degrees Celsius) {ECO 0000269|PubMed 16101288, ECO 0000269|PubMed 3911944, ECO 0000269|PubMed 8941345}; KM=0.8 uM for 5'-methylthioadenosine (at pH 7 and 22 degrees Celsius) {ECO 0000269|PubMed 16101288, ECO 0000269|PubMed 3911944, ECO 0000269|PubMed 8941345}; KM=4.3 uM for S-adenosylhomocysteine (at pH 7 and 37 degrees Celsius) {ECO 0000269|PubMed 16101288, ECO 0000269|PubMed 3911944, ECO 0000269|PubMed 8941345}; KM=1.3 uM for S-adenosylhomocysteine (at pH 7 and 22 degrees Celsius) {ECO 0000269|PubMed 16101288, ECO 0000269|PubMed 3911944, ECO 0000269|PubMed 8941345}; Vmax=373 umol/min/mg enzyme with 5'-methylthioadenosine as substrate (at pH 7 and 37 degrees Celsius) {ECO 0000269|PubMed 16101288, ECO 0000269|PubMed 3911944, ECO 0000269|PubMed 8941345}; Vmax=156 umol/min/mg enzyme with S-adenosylhomocysteine as substrate (at pH 7 and 37 degrees Celsius) {ECO 0000269|PubMed 16101288, ECO 0000269|PubMed 3911944, ECO 0000269|PubMed 8941345}; Note=kcat is 3.0 sec(-1) and 2.6 sec(-1) with 5'- methylthioadenosine and S-adenosylhomocysteine as substrate, respectively. {ECO 0000269|PubMed 16101288}; pH dependence Exhibits activity across a broad pH range. Enzyme activity is moderately improved under acidic conditions. {ECO 0000269|PubMed 3911944, ECO 0000269|PubMed 8941345}; Temperature dependence Optimum temperature is 37-45 degrees Celsius. Rapidly inactivated after exposure for 10 minutes at 55 degrees Celsius. {ECO 0000269|PubMed 3911944, ECO 0000269|PubMed 8941345}; # BRENDA 3.2.2 2026 # BRENDA 3.2.2.30 2026 # BioGrid 4260991 6 # CATALYTIC ACTIVITY S-adenosyl-L-homocysteine + H(2)O = S-(5- deoxy-D-ribos-5-yl)-L-homocysteine + adenine. {ECO:0000269|PubMed 16101288}. # CATALYTIC ACTIVITY S-methyl-5'-thioadenosine + H(2)O = S-methyl- 5-thio-D-ribose + adenine. {ECO:0000269|PubMed 16101288}. # DrugBank DB00173 Adenine # ENZYME REGULATION MTNN_ECOLI Strongly inhibited by aryl-substituted MTA analogs, alkyl-substituted MTA analogs, 5'-methylthioformycin, 5'- chloroformycin, S-formycinylhomocysteine, 5'-methylthiotubercidin, S-tubercidinylhomocysteine and S-8-aza-adenosylhomocysteine. Poorly inhibited by 5'-isobutylthioinosine, 5'-n-butylthioinosine, 5'-methylthio-3-deaza-adenosine, 5'-isobutylthio-3-deaza- adenosine, S-n-6-methyl-3-deaza-adenosylhomocysteine, S- adenosylhomocysteine sulphoxide and Sinefungin. {ECO 0000269|PubMed 12496243, ECO 0000269|PubMed 15749708, ECO 0000269|PubMed 3911944, ECO 0000269|PubMed 8941345}. # EcoGene EG11090 pfs # FUNCTION MTNN_ECOLI Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Can also use 5'-isobutylthioadenosine, 5'-n- butylthioadenosine, S-adenosyl-D-homocysteine, decarboxylated adenosylhomocysteine, deaminated adenosylhomocysteine and S-2-aza- adenosylhomocysteine as substrates. {ECO 0000269|PubMed 16101288}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008782 adenosylhomocysteine nucleosidase activity; IDA:EcoCyc. # GO_function GO:0008930 methylthioadenosine nucleosidase activity; IDA:EcoCyc. # GO_process GO:0009164 nucleoside catabolic process; IEA:InterPro. # GO_process GO:0019284 L-methionine biosynthetic process from S-adenosylmethionine; IDA:EcoCyc. # GO_process GO:0019509 L-methionine biosynthetic process from methylthioadenosine; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.1580 -; 1. # HAMAP MF_01684 Salvage_MtnN # IntAct P0AF12 7 # InterPro IPR000845 Nucleoside_phosphorylase_d # InterPro IPR010049 MTA_SAH_Nsdase # InterPro IPR018017 Nucleoside_phosphorylase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00270 Cysteine and methionine metabolism # Organism MTNN_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21234 PTHR21234 # PATHWAY Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route) step 1/2. # PATRIC 32115427 VBIEscCol129921_0165 # PDB 1JYS X-ray; 1.90 A; A/B=1-232 # PDB 1NC1 X-ray; 2.00 A; A/B=1-232 # PDB 1NC3 X-ray; 2.20 A; A/B=1-232 # PDB 1Y6Q X-ray; 2.20 A; A/B=1-232 # PDB 1Y6R X-ray; 2.20 A; A/B=1-232 # PDB 1Z5N X-ray; 2.10 A; A/B=1-232 # PDB 1Z5O X-ray; 2.00 A; A/B=1-232 # PDB 1Z5P X-ray; 2.00 A; A=1-232 # PDB 3O4V X-ray; 1.75 A; A/B=1-232 # PDB 4WKC X-ray; 1.64 A; A=1-232 # PDB 4YML X-ray; 1.75 A; A=1-232 # PIR S45227 S45227 # Pfam PF01048 PNP_UDP_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MTNN_ECOLI 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase # RefSeq NP_414701 NC_000913.3 # RefSeq WP_000689844 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA23678.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. {ECO 0000305}. # SUBUNIT MTNN_ECOLI Homodimer. {ECO 0000269|PubMed 11591349, ECO 0000269|PubMed 12496243, ECO 0000269|PubMed 15749708, ECO 0000269|PubMed 16109423}. # SUPFAM SSF53167 SSF53167 # TIGRFAMs TIGR01704 MTA/SAH-Nsdase # UniPathway UPA00904 UER00871 # eggNOG COG0775 LUCA # eggNOG ENOG4105DUF Bacteria BLAST swissprot:MTNN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MTNN_ECOLI BioCyc ECOL316407:JW0155-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0155-MONOMER BioCyc EcoCyc:EG11090-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11090-MONOMER BioCyc MetaCyc:EG11090-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11090-MONOMER COG COG0775 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0775 DIP DIP-10270N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10270N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/bbrc.1996.1723 http://dx.doi.org/10.1006/bbrc.1996.1723 DOI 10.1016/S0167-4781(97)00169-3 http://dx.doi.org/10.1016/S0167-4781(97)00169-3 DOI 10.1016/S0969-2126(01)00656-6 http://dx.doi.org/10.1016/S0969-2126(01)00656-6 DOI 10.1016/j.jmb.2005.07.027 http://dx.doi.org/10.1016/j.jmb.2005.07.027 DOI 10.1021/bi050493q http://dx.doi.org/10.1021/bi050493q DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.87.7.2740 http://dx.doi.org/10.1073/pnas.87.7.2740 DOI 10.1074/jbc.M210836200 http://dx.doi.org/10.1074/jbc.M210836200 DOI 10.1074/jbc.M414472200 http://dx.doi.org/10.1074/jbc.M414472200 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB00173 http://www.drugbank.ca/drugs/DB00173 EC_number EC:3.2.2.9 http://www.genome.jp/dbget-bin/www_bget?EC:3.2.2.9 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M31772 http://www.ebi.ac.uk/ena/data/view/M31772 EMBL M83735 http://www.ebi.ac.uk/ena/data/view/M83735 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U24438 http://www.ebi.ac.uk/ena/data/view/U24438 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 ENZYME 3.2.2.9 http://enzyme.expasy.org/EC/3.2.2.9 EchoBASE EB1082 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1082 EcoGene EG11090 http://www.ecogene.org/geneInfo.php?eg_id=EG11090 EnsemblBacteria AAC73270 http://www.ensemblgenomes.org/id/AAC73270 EnsemblBacteria AAC73270 http://www.ensemblgenomes.org/id/AAC73270 EnsemblBacteria BAB96736 http://www.ensemblgenomes.org/id/BAB96736 EnsemblBacteria BAB96736 http://www.ensemblgenomes.org/id/BAB96736 EnsemblBacteria BAB96736 http://www.ensemblgenomes.org/id/BAB96736 EnsemblBacteria b0159 http://www.ensemblgenomes.org/id/b0159 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008782 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008782 GO_function GO:0008930 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008930 GO_process GO:0009164 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009164 GO_process GO:0019284 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019284 GO_process GO:0019509 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019509 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.1580 http://www.cathdb.info/version/latest/superfamily/3.40.50.1580 GeneID 948542 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948542 HAMAP MF_01684 http://hamap.expasy.org/unirule/MF_01684 HOGENOM HOG000259346 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000259346&db=HOGENOM6 InParanoid P0AF12 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AF12 IntAct P0AF12 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AF12* IntEnz 3.2.2.9 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.2.2.9 InterPro IPR000845 http://www.ebi.ac.uk/interpro/entry/IPR000845 InterPro IPR010049 http://www.ebi.ac.uk/interpro/entry/IPR010049 InterPro IPR018017 http://www.ebi.ac.uk/interpro/entry/IPR018017 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0155 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0155 KEGG_Gene eco:b0159 http://www.genome.jp/dbget-bin/www_bget?eco:b0159 KEGG_Orthology KO:K01243 http://www.genome.jp/dbget-bin/www_bget?KO:K01243 KEGG_Pathway ko00270 http://www.genome.jp/kegg-bin/show_pathway?ko00270 KEGG_Reaction rn:R00194 http://www.genome.jp/dbget-bin/www_bget?rn:R00194 KEGG_Reaction rn:R01401 http://www.genome.jp/dbget-bin/www_bget?rn:R01401 OMA LLERCKP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LLERCKP PANTHER PTHR21234 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21234 PDB 1JYS http://www.ebi.ac.uk/pdbe-srv/view/entry/1JYS PDB 1NC1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1NC1 PDB 1NC3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1NC3 PDB 1Y6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/1Y6Q PDB 1Y6R http://www.ebi.ac.uk/pdbe-srv/view/entry/1Y6R PDB 1Z5N http://www.ebi.ac.uk/pdbe-srv/view/entry/1Z5N PDB 1Z5O http://www.ebi.ac.uk/pdbe-srv/view/entry/1Z5O PDB 1Z5P http://www.ebi.ac.uk/pdbe-srv/view/entry/1Z5P PDB 3O4V http://www.ebi.ac.uk/pdbe-srv/view/entry/3O4V PDB 4WKC http://www.ebi.ac.uk/pdbe-srv/view/entry/4WKC PDB 4YML http://www.ebi.ac.uk/pdbe-srv/view/entry/4YML PDBsum 1JYS http://www.ebi.ac.uk/pdbsum/1JYS PDBsum 1NC1 http://www.ebi.ac.uk/pdbsum/1NC1 PDBsum 1NC3 http://www.ebi.ac.uk/pdbsum/1NC3 PDBsum 1Y6Q http://www.ebi.ac.uk/pdbsum/1Y6Q PDBsum 1Y6R http://www.ebi.ac.uk/pdbsum/1Y6R PDBsum 1Z5N http://www.ebi.ac.uk/pdbsum/1Z5N PDBsum 1Z5O http://www.ebi.ac.uk/pdbsum/1Z5O PDBsum 1Z5P http://www.ebi.ac.uk/pdbsum/1Z5P PDBsum 3O4V http://www.ebi.ac.uk/pdbsum/3O4V PDBsum 4WKC http://www.ebi.ac.uk/pdbsum/4WKC PDBsum 4YML http://www.ebi.ac.uk/pdbsum/4YML PSORT swissprot:MTNN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MTNN_ECOLI PSORT-B swissprot:MTNN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MTNN_ECOLI PSORT2 swissprot:MTNN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MTNN_ECOLI Pfam PF01048 http://pfam.xfam.org/family/PF01048 Phobius swissprot:MTNN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MTNN_ECOLI PhylomeDB P0AF12 http://phylomedb.org/?seqid=P0AF12 ProteinModelPortal P0AF12 http://www.proteinmodelportal.org/query/uniprot/P0AF12 PubMed 11591349 http://www.ncbi.nlm.nih.gov/pubmed/11591349 PubMed 12496243 http://www.ncbi.nlm.nih.gov/pubmed/12496243 PubMed 15749708 http://www.ncbi.nlm.nih.gov/pubmed/15749708 PubMed 16101288 http://www.ncbi.nlm.nih.gov/pubmed/16101288 PubMed 16109423 http://www.ncbi.nlm.nih.gov/pubmed/16109423 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2157212 http://www.ncbi.nlm.nih.gov/pubmed/2157212 PubMed 3911944 http://www.ncbi.nlm.nih.gov/pubmed/3911944 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 8941345 http://www.ncbi.nlm.nih.gov/pubmed/8941345 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9524204 http://www.ncbi.nlm.nih.gov/pubmed/9524204 RefSeq NP_414701 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414701 RefSeq WP_000689844 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000689844 SMR P0AF12 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AF12 STRING 511145.b0159 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0159&targetmode=cogs STRING COG0775 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0775&targetmode=cogs SUPFAM SSF53167 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53167 SWISS-2DPAGE P0AF12 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AF12 TIGRFAMs TIGR01704 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01704 UniProtKB MTNN_ECOLI http://www.uniprot.org/uniprot/MTNN_ECOLI UniProtKB-AC P0AF12 http://www.uniprot.org/uniprot/P0AF12 charge swissprot:MTNN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MTNN_ECOLI eggNOG COG0775 http://eggnogapi.embl.de/nog_data/html/tree/COG0775 eggNOG ENOG4105DUF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DUF epestfind swissprot:MTNN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MTNN_ECOLI garnier swissprot:MTNN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MTNN_ECOLI helixturnhelix swissprot:MTNN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MTNN_ECOLI hmoment swissprot:MTNN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MTNN_ECOLI iep swissprot:MTNN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MTNN_ECOLI inforesidue swissprot:MTNN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MTNN_ECOLI octanol swissprot:MTNN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MTNN_ECOLI pepcoil swissprot:MTNN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MTNN_ECOLI pepdigest swissprot:MTNN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MTNN_ECOLI pepinfo swissprot:MTNN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MTNN_ECOLI pepnet swissprot:MTNN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MTNN_ECOLI pepstats swissprot:MTNN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MTNN_ECOLI pepwheel swissprot:MTNN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MTNN_ECOLI pepwindow swissprot:MTNN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MTNN_ECOLI sigcleave swissprot:MTNN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MTNN_ECOLI ## Database ID URL or Descriptions # BioGrid 4261123 398 # DISRUPTION PHENOTYPE CSDE_ECOLI Cells lacking this gene display a high decrease in the level of ct(6)A modification in tRNAs, and show the t(6)A modification instead. They also show no defects in motility, fitness or antibiotic sensitivity, in contrast to csdA mutants. {ECO 0000269|PubMed 20054882, ECO 0000269|PubMed 23242255}. # EcoGene EG13083 csdE # FUNCTION CSDE_ECOLI Stimulates the cysteine desulfurase activity of CsdA. Contains a cysteine residue (Cys-61) that acts to accept sulfur liberated via the desulfurase activity of CsdA. May be able to transfer sulfur to TcdA/CsdL. Seems to support the function of TcdA in the generation of cyclic threonylcarbamoyladenosine at position 37 (ct(6)A37) in tRNAs that read codons beginning with adenine. Does not appear to participate in Fe/S biogenesis. {ECO 0000269|PubMed 15901727, ECO 0000269|PubMed 20054882, ECO 0000269|PubMed 23242255}. # GO_process GO:0016226 iron-sulfur cluster assembly; IDA:EcoCyc. # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0051186 cofactor metabolic process # INTERACTION CSDE_ECOLI Q46925 csdA; NbExp=8; IntAct=EBI-1130454, EBI-545660; Q46927 tcdA; NbExp=3; IntAct=EBI-1130454, EBI-1130463; # IntAct P0AGF2 5 # InterPro IPR003808 Fe-S_metab-assoc_dom # InterPro IPR017763 Cysteine_desulfurase_CsdE # Organism CSDE_ECOLI Escherichia coli (strain K12) # PATRIC 32121038 VBIEscCol129921_2911 # PDB 1NI7 NMR; -; A=1-147 # PDB 5EEP X-ray; 2.40 A; A=1-147 # PIR G65063 G65063 # Pfam PF02657 SufE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CSDE_ECOLI Sulfur acceptor protein CsdE # RefSeq NP_417291 NC_000913.3 # RefSeq WP_000184261 NZ_LN832404.1 # SIMILARITY Belongs to the SufE family. {ECO 0000305}. # SUBUNIT CSDE_ECOLI Homodimer. Forms a heterodimer with CsdA. Interacts with CsdA and with TcdA/CsdL. {ECO 0000269|PubMed 15901727, ECO 0000269|PubMed 20054882}. # TIGRFAMs TIGR03391 FeS_syn_CsdE # eggNOG COG2166 LUCA # eggNOG ENOG4105P9C Bacteria BLAST swissprot:CSDE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CSDE_ECOLI BioCyc ECOL316407:JW2782-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2782-MONOMER BioCyc EcoCyc:G7455-MONOMER http://biocyc.org/getid?id=EcoCyc:G7455-MONOMER BioCyc MetaCyc:G7455-MONOMER http://biocyc.org/getid?id=MetaCyc:G7455-MONOMER COG COG2166 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2166 DIP DIP-12143N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12143N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nchembio.1137 http://dx.doi.org/10.1038/nchembio.1137 DOI 10.1074/jbc.M504067200 http://dx.doi.org/10.1074/jbc.M504067200 DOI 10.1110/ps.041322705 http://dx.doi.org/10.1110/ps.041322705 DOI 10.1111/j.1365-2958.2009.06954.x http://dx.doi.org/10.1111/j.1365-2958.2009.06954.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 EchoBASE EB2892 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2892 EcoGene EG13083 http://www.ecogene.org/geneInfo.php?eg_id=EG13083 EnsemblBacteria AAC75853 http://www.ensemblgenomes.org/id/AAC75853 EnsemblBacteria AAC75853 http://www.ensemblgenomes.org/id/AAC75853 EnsemblBacteria BAE76883 http://www.ensemblgenomes.org/id/BAE76883 EnsemblBacteria BAE76883 http://www.ensemblgenomes.org/id/BAE76883 EnsemblBacteria BAE76883 http://www.ensemblgenomes.org/id/BAE76883 EnsemblBacteria b2811 http://www.ensemblgenomes.org/id/b2811 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0016226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016226 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GeneID 947274 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947274 HOGENOM HOG000285041 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000285041&db=HOGENOM6 InParanoid P0AGF2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGF2 IntAct P0AGF2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AGF2* InterPro IPR003808 http://www.ebi.ac.uk/interpro/entry/IPR003808 InterPro IPR017763 http://www.ebi.ac.uk/interpro/entry/IPR017763 KEGG_Gene ecj:JW2782 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2782 KEGG_Gene eco:b2811 http://www.genome.jp/dbget-bin/www_bget?eco:b2811 KEGG_Orthology KO:K02426 http://www.genome.jp/dbget-bin/www_bget?KO:K02426 OMA CESKVWL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CESKVWL PDB 1NI7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1NI7 PDB 5EEP http://www.ebi.ac.uk/pdbe-srv/view/entry/5EEP PDBsum 1NI7 http://www.ebi.ac.uk/pdbsum/1NI7 PDBsum 5EEP http://www.ebi.ac.uk/pdbsum/5EEP PSORT swissprot:CSDE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CSDE_ECOLI PSORT-B swissprot:CSDE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CSDE_ECOLI PSORT2 swissprot:CSDE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CSDE_ECOLI Pfam PF02657 http://pfam.xfam.org/family/PF02657 Phobius swissprot:CSDE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CSDE_ECOLI PhylomeDB P0AGF2 http://phylomedb.org/?seqid=P0AGF2 ProteinModelPortal P0AGF2 http://www.proteinmodelportal.org/query/uniprot/P0AGF2 PubMed 15901727 http://www.ncbi.nlm.nih.gov/pubmed/15901727 PubMed 15930006 http://www.ncbi.nlm.nih.gov/pubmed/15930006 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20054882 http://www.ncbi.nlm.nih.gov/pubmed/20054882 PubMed 23242255 http://www.ncbi.nlm.nih.gov/pubmed/23242255 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417291 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417291 RefSeq WP_000184261 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000184261 SMR P0AGF2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AGF2 STRING 511145.b2811 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2811&targetmode=cogs STRING COG2166 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2166&targetmode=cogs TIGRFAMs TIGR03391 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03391 UniProtKB CSDE_ECOLI http://www.uniprot.org/uniprot/CSDE_ECOLI UniProtKB-AC P0AGF2 http://www.uniprot.org/uniprot/P0AGF2 charge swissprot:CSDE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CSDE_ECOLI eggNOG COG2166 http://eggnogapi.embl.de/nog_data/html/tree/COG2166 eggNOG ENOG4105P9C http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105P9C epestfind swissprot:CSDE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CSDE_ECOLI garnier swissprot:CSDE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CSDE_ECOLI helixturnhelix swissprot:CSDE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CSDE_ECOLI hmoment swissprot:CSDE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CSDE_ECOLI iep swissprot:CSDE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CSDE_ECOLI inforesidue swissprot:CSDE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CSDE_ECOLI octanol swissprot:CSDE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CSDE_ECOLI pepcoil swissprot:CSDE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CSDE_ECOLI pepdigest swissprot:CSDE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CSDE_ECOLI pepinfo swissprot:CSDE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CSDE_ECOLI pepnet swissprot:CSDE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CSDE_ECOLI pepstats swissprot:CSDE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CSDE_ECOLI pepwheel swissprot:CSDE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CSDE_ECOLI pepwindow swissprot:CSDE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CSDE_ECOLI sigcleave swissprot:CSDE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CSDE_ECOLI ## Database ID URL or Descriptions # AltName GUAA_ECOLI GMP synthetase # AltName GUAA_ECOLI Glutamine amidotransferase # BRENDA 6.3.5 2026 # BioGrid 4259645 32 # CATALYTIC ACTIVITY GUAA_ECOLI ATP + XMP + L-glutamine + H(2)O = AMP + diphosphate + GMP + L-glutamate. # CDD cd01742 GATase1_GMP_Synthase # CDD cd01997 GMP_synthase_C # ENZYME REGULATION Inhibited by 2-fluoroinosine 5'-monophosphate (F-IMP) and by N(2)-hydroxyguanosine 5'-monophosphate (N(2)-OH- GMP). {ECO:0000269|PubMed 9890911}. # EcoGene EG10420 guaA # FUNCTION GUAA_ECOLI Catalyzes the synthesis of GMP from XMP. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0003921 GMP synthase activity; IDA:EcoCyc. # GO_function GO:0003922 GMP synthase (glutamine-hydrolyzing) activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0016462 pyrophosphatase activity; IEA:InterPro. # GO_process GO:0006177 GMP biosynthetic process; IMP:EcoCyc. # GO_process GO:0006541 glutamine metabolic process; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.620 -; 1. # Gene3D 3.40.50.880 -; 1. # HAMAP MF_00344 GMP_synthase # INDUCTION GUAA_ECOLI Activated by cAMP receptor protein (CRP). Repressed by DnaA. # INTERACTION GUAA_ECOLI Self; NbExp=2; IntAct=EBI-909122, EBI-909122; # IntAct P04079 8 # InterPro IPR001674 GMP_synth_C # InterPro IPR004739 GMP_synth_GATase # InterPro IPR014729 Rossmann-like_a/b/a_fold # InterPro IPR017926 GATASE # InterPro IPR022310 NAD/GMP_synthase # InterPro IPR022955 GMP_synthase # InterPro IPR025777 GMPS_ATP_PPase_dom # InterPro IPR029062 Class_I_gatase-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00983 Drug metabolism - other enzymes # Organism GUAA_ECOLI Escherichia coli (strain K12) # PATHWAY Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route) step 1/1. # PATRIC 32120405 VBIEscCol129921_2605 # PDB 1GPM X-ray; 2.20 A; A/B/C/D=1-525 # PIR A24640 SYECGU # PROSITE PS51273 GATASE_TYPE_1 # PROSITE PS51553 GMPS_ATP_PPASE # Pfam PF00117 GATase # Pfam PF00958 GMP_synt_C # Pfam PF02540 NAD_synthase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GUAA_ECOLI GMP synthase [glutamine-hydrolyzing] # RefSeq NP_417002 NC_000913.3 # RefSeq WP_000138270 NZ_LN832404.1 # SIMILARITY Contains 1 GMPS ATP-PPase (ATP pyrophosphatase) domain. {ECO 0000305}. # SIMILARITY Contains 1 glutamine amidotransferase type-1 domain. {ECO 0000305}. # SUBUNIT GUAA_ECOLI Homodimer. # SUPFAM SSF52317 SSF52317 # TIGRFAMs TIGR00884 guaA_Cterm # TIGRFAMs TIGR00888 guaA_Nterm # UniPathway UPA00189 UER00296 # eggNOG COG0518 LUCA # eggNOG COG0519 LUCA # eggNOG ENOG4105CM0 Bacteria BLAST swissprot:GUAA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GUAA_ECOLI BioCyc ECOL316407:JW2491-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2491-MONOMER BioCyc EcoCyc:GMP-SYN-MONOMER http://biocyc.org/getid?id=EcoCyc:GMP-SYN-MONOMER BioCyc MetaCyc:GMP-SYN-MONOMER http://biocyc.org/getid?id=MetaCyc:GMP-SYN-MONOMER COG COG0518 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0518 COG COG0519 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0519 DIP DIP-9852N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9852N DOI 10.1021/bi981980r http://dx.doi.org/10.1021/bi981980r DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb0196-74 http://dx.doi.org/10.1038/nsb0196-74 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1574-6968.2000.tb09146.x http://dx.doi.org/10.1111/j.1574-6968.2000.tb09146.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.3.5.2 http://www.genome.jp/dbget-bin/www_bget?EC:6.3.5.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M10101 http://www.ebi.ac.uk/ena/data/view/M10101 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 6.3.5.2 http://enzyme.expasy.org/EC/6.3.5.2 EchoBASE EB0415 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0415 EcoGene EG10420 http://www.ecogene.org/geneInfo.php?eg_id=EG10420 EnsemblBacteria AAC75560 http://www.ensemblgenomes.org/id/AAC75560 EnsemblBacteria AAC75560 http://www.ensemblgenomes.org/id/AAC75560 EnsemblBacteria BAA16394 http://www.ensemblgenomes.org/id/BAA16394 EnsemblBacteria BAA16394 http://www.ensemblgenomes.org/id/BAA16394 EnsemblBacteria BAA16394 http://www.ensemblgenomes.org/id/BAA16394 EnsemblBacteria b2507 http://www.ensemblgenomes.org/id/b2507 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003921 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003921 GO_function GO:0003922 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003922 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016462 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016462 GO_process GO:0006177 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006177 GO_process GO:0006541 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006541 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 Gene3D 3.40.50.880 http://www.cathdb.info/version/latest/superfamily/3.40.50.880 GeneID 947334 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947334 HAMAP MF_00344 http://hamap.expasy.org/unirule/MF_00344 HOGENOM HOG000223964 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000223964&db=HOGENOM6 InParanoid P04079 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P04079 IntAct P04079 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P04079* IntEnz 6.3.5.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.5.2 InterPro IPR001674 http://www.ebi.ac.uk/interpro/entry/IPR001674 InterPro IPR004739 http://www.ebi.ac.uk/interpro/entry/IPR004739 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 InterPro IPR017926 http://www.ebi.ac.uk/interpro/entry/IPR017926 InterPro IPR022310 http://www.ebi.ac.uk/interpro/entry/IPR022310 InterPro IPR022955 http://www.ebi.ac.uk/interpro/entry/IPR022955 InterPro IPR025777 http://www.ebi.ac.uk/interpro/entry/IPR025777 InterPro IPR029062 http://www.ebi.ac.uk/interpro/entry/IPR029062 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW2491 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2491 KEGG_Gene eco:b2507 http://www.genome.jp/dbget-bin/www_bget?eco:b2507 KEGG_Orthology KO:K01951 http://www.genome.jp/dbget-bin/www_bget?KO:K01951 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00983 http://www.genome.jp/kegg-bin/show_pathway?ko00983 KEGG_Reaction rn:R01230 http://www.genome.jp/dbget-bin/www_bget?rn:R01230 KEGG_Reaction rn:R01231 http://www.genome.jp/dbget-bin/www_bget?rn:R01231 KEGG_Reaction rn:R08244 http://www.genome.jp/dbget-bin/www_bget?rn:R08244 OMA MILVLDF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MILVLDF PDB 1GPM http://www.ebi.ac.uk/pdbe-srv/view/entry/1GPM PDBsum 1GPM http://www.ebi.ac.uk/pdbsum/1GPM PROSITE PS51273 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51273 PROSITE PS51553 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51553 PSORT swissprot:GUAA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GUAA_ECOLI PSORT-B swissprot:GUAA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GUAA_ECOLI PSORT2 swissprot:GUAA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GUAA_ECOLI Pfam PF00117 http://pfam.xfam.org/family/PF00117 Pfam PF00958 http://pfam.xfam.org/family/PF00958 Pfam PF02540 http://pfam.xfam.org/family/PF02540 Phobius swissprot:GUAA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GUAA_ECOLI PhylomeDB P04079 http://phylomedb.org/?seqid=P04079 ProteinModelPortal P04079 http://www.proteinmodelportal.org/query/uniprot/P04079 PubMed 10856643 http://www.ncbi.nlm.nih.gov/pubmed/10856643 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1736096 http://www.ncbi.nlm.nih.gov/pubmed/1736096 PubMed 2982857 http://www.ncbi.nlm.nih.gov/pubmed/2982857 PubMed 3894345 http://www.ncbi.nlm.nih.gov/pubmed/3894345 PubMed 8548458 http://www.ncbi.nlm.nih.gov/pubmed/8548458 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9890911 http://www.ncbi.nlm.nih.gov/pubmed/9890911 RefSeq NP_417002 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417002 RefSeq WP_000138270 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000138270 SMR P04079 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P04079 STRING 511145.b2507 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2507&targetmode=cogs STRING COG0518 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0518&targetmode=cogs STRING COG0519 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0519&targetmode=cogs SUPFAM SSF52317 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52317 TIGRFAMs TIGR00884 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00884 TIGRFAMs TIGR00888 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00888 UniProtKB GUAA_ECOLI http://www.uniprot.org/uniprot/GUAA_ECOLI UniProtKB-AC P04079 http://www.uniprot.org/uniprot/P04079 charge swissprot:GUAA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GUAA_ECOLI eggNOG COG0518 http://eggnogapi.embl.de/nog_data/html/tree/COG0518 eggNOG COG0519 http://eggnogapi.embl.de/nog_data/html/tree/COG0519 eggNOG ENOG4105CM0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CM0 epestfind swissprot:GUAA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GUAA_ECOLI garnier swissprot:GUAA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GUAA_ECOLI helixturnhelix swissprot:GUAA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GUAA_ECOLI hmoment swissprot:GUAA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GUAA_ECOLI iep swissprot:GUAA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GUAA_ECOLI inforesidue swissprot:GUAA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GUAA_ECOLI octanol swissprot:GUAA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GUAA_ECOLI pepcoil swissprot:GUAA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GUAA_ECOLI pepdigest swissprot:GUAA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GUAA_ECOLI pepinfo swissprot:GUAA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GUAA_ECOLI pepnet swissprot:GUAA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GUAA_ECOLI pepstats swissprot:GUAA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GUAA_ECOLI pepwheel swissprot:GUAA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GUAA_ECOLI pepwindow swissprot:GUAA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GUAA_ECOLI sigcleave swissprot:GUAA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GUAA_ECOLI ## Database ID URL or Descriptions # EcoGene EG14476 ykgR # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # INDUCTION YKGR_ECOLI Constitutively expressed (PubMed 19121005), repressed in minimal glucose medium, by SDS/EDTA (envelope stress), at 10 degrees Celsius and H(2)O(2), induced in minimal glycerol medium, by thiol oxidant diamide, strongly induced at 45 degrees Celsius (PubMed 19734316) (at protein level). Transcription is dependent on CRP. {ECO 0000269|PubMed 19121005, ECO 0000269|PubMed 19734316}. # Organism YKGR_ECOLI Escherichia coli (strain K12) # PATRIC 32115721 VBIEscCol129921_0303 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YKGR_ECOLI Uncharacterized membrane protein YkgR # RefSeq WP_000662258 NZ_LN832404.1 # RefSeq YP_002791238 NC_000913.3 # SUBCELLULAR LOCATION YKGR_ECOLI Cell inner membrane {ECO 0000305|PubMed 21778229}; Single-pass membrane protein {ECO 0000305|PubMed 21778229}. BLAST swissprot:YKGR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YKGR_ECOLI BioCyc EcoCyc:MONOMER0-2881 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2881 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M111.245696 http://dx.doi.org/10.1074/jbc.M111.245696 DOI 10.1111/j.1365-2958.2008.06495.x http://dx.doi.org/10.1111/j.1365-2958.2008.06495.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00872-09 http://dx.doi.org/10.1128/JB.00872-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14476 http://www.ecogene.org/geneInfo.php?eg_id=EG14476 EnsemblBacteria ACO59990 http://www.ensemblgenomes.org/id/ACO59990 EnsemblBacteria ACO59990 http://www.ensemblgenomes.org/id/ACO59990 EnsemblBacteria b4671 http://www.ensemblgenomes.org/id/b4671 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 7751635 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7751635 HOGENOM HOG000009336 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009336&db=HOGENOM6 KEGG_Gene eco:b4671 http://www.genome.jp/dbget-bin/www_bget?eco:b4671 PSORT swissprot:YKGR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YKGR_ECOLI PSORT-B swissprot:YKGR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YKGR_ECOLI PSORT2 swissprot:YKGR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YKGR_ECOLI Phobius swissprot:YKGR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YKGR_ECOLI PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19121005 http://www.ncbi.nlm.nih.gov/pubmed/19121005 PubMed 19734316 http://www.ncbi.nlm.nih.gov/pubmed/19734316 PubMed 21778229 http://www.ncbi.nlm.nih.gov/pubmed/21778229 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000662258 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000662258 RefSeq YP_002791238 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_002791238 STRING 511145.b4671 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4671&targetmode=cogs UniProtKB YKGR_ECOLI http://www.uniprot.org/uniprot/YKGR_ECOLI UniProtKB-AC C1P5Z8 http://www.uniprot.org/uniprot/C1P5Z8 charge swissprot:YKGR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YKGR_ECOLI epestfind swissprot:YKGR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YKGR_ECOLI garnier swissprot:YKGR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YKGR_ECOLI helixturnhelix swissprot:YKGR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YKGR_ECOLI hmoment swissprot:YKGR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YKGR_ECOLI iep swissprot:YKGR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YKGR_ECOLI inforesidue swissprot:YKGR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YKGR_ECOLI octanol swissprot:YKGR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YKGR_ECOLI pepcoil swissprot:YKGR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YKGR_ECOLI pepdigest swissprot:YKGR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YKGR_ECOLI pepinfo swissprot:YKGR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YKGR_ECOLI pepnet swissprot:YKGR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YKGR_ECOLI pepstats swissprot:YKGR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YKGR_ECOLI pepwheel swissprot:YKGR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YKGR_ECOLI pepwindow swissprot:YKGR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YKGR_ECOLI sigcleave swissprot:YKGR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YKGR_ECOLI ## Database ID URL or Descriptions # AltName SYY_ECOLI Tyrosyl-tRNA synthetase # BRENDA 6.1.1 2026 # BioGrid 4263487 17 # CATALYTIC ACTIVITY SYY_ECOLI ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr). # CDD cd00805 TyrRS_core # EcoGene EG11043 tyrS # FUNCTION SYY_ECOLI Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr). # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0003723 RNA binding; IEA:UniProtKB-KW. # GO_function GO:0004831 tyrosine-tRNA ligase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006437 tyrosyl-tRNA aminoacylation; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0006520 cellular amino acid metabolic process # Gene3D 3.10.290.10 -; 1. # Gene3D 3.40.50.620 -; 1. # HAMAP MF_02006 Tyr_tRNA_synth_type1 # IntAct P0AGJ9 8 # InterPro IPR001412 aa-tRNA-synth_I_CS # InterPro IPR002305 aa-tRNA-synth_Ic # InterPro IPR002307 Tyr-tRNA-ligase # InterPro IPR002942 S4_RNA-bd # InterPro IPR014729 Rossmann-like_a/b/a_fold # InterPro IPR024088 Tyr-tRNA-ligase_bac-type # InterPro IPR024107 Tyr-tRNA-ligase_bac_1 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01007 Amino acid related enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # KEGG_Pathway ko00970 Aminoacyl-tRNA biosynthesis # Organism SYY_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11766 PTHR11766 # PATRIC 32118576 VBIEscCol129921_1708 # PDB 1VBM X-ray; 2.70 A; A/B=5-322 # PDB 1VBN X-ray; 2.70 A; A/B=5-322 # PDB 1WQ3 X-ray; 2.00 A; A=1-322 # PDB 1WQ4 X-ray; 2.00 A; A=2-322 # PDB 1X8X X-ray; 2.00 A; A=1-322 # PDB 2YXN X-ray; 1.80 A; A=1-322 # PIR A01178 SYECYT # PRINTS PR01040 TRNASYNTHTYR # PROSITE PS00178 AA_TRNA_LIGASE_I # PROSITE PS50889 S4 # Pfam PF00579 tRNA-synt_1b # Pfam PF01479 S4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SYY_ECOLI Tyrosine--tRNA ligase # RefSeq NP_416154 NC_000913.3 # RefSeq WP_001295400 NZ_LN832404.1 # SIMILARITY Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. {ECO 0000305}. # SIMILARITY Contains 1 S4 RNA-binding domain. {ECO 0000305}. # SMART SM00363 S4 # SUBCELLULAR LOCATION SYY_ECOLI Cytoplasm. # SUBUNIT SYY_ECOLI Homodimer. {ECO 0000269|PubMed 15663931, ECO 0000269|PubMed 15671170}. # TIGRFAMs TIGR00234 tyrS # eggNOG COG0162 LUCA # eggNOG ENOG4105DA0 Bacteria BLAST swissprot:SYY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SYY_ECOLI BioCyc ECOL316407:JW1629-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1629-MONOMER BioCyc EcoCyc:TYRS-MONOMER http://biocyc.org/getid?id=EcoCyc:TYRS-MONOMER BioCyc MetaCyc:TYRS-MONOMER http://biocyc.org/getid?id=MetaCyc:TYRS-MONOMER COG COG0162 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0162 DIP DIP-36227N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36227N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0014-5793(82)80781-3 http://dx.doi.org/10.1016/0014-5793(82)80781-3 DOI 10.1016/j.jmb.2004.11.034 http://dx.doi.org/10.1016/j.jmb.2004.11.034 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0407039102 http://dx.doi.org/10.1073/pnas.0407039102 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.1.1.1 http://www.genome.jp/dbget-bin/www_bget?EC:6.1.1.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01719 http://www.ebi.ac.uk/ena/data/view/J01719 EMBL M92351 http://www.ebi.ac.uk/ena/data/view/M92351 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 6.1.1.1 http://enzyme.expasy.org/EC/6.1.1.1 EchoBASE EB1036 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1036 EcoGene EG11043 http://www.ecogene.org/geneInfo.php?eg_id=EG11043 EnsemblBacteria AAC74709 http://www.ensemblgenomes.org/id/AAC74709 EnsemblBacteria AAC74709 http://www.ensemblgenomes.org/id/AAC74709 EnsemblBacteria BAA15398 http://www.ensemblgenomes.org/id/BAA15398 EnsemblBacteria BAA15398 http://www.ensemblgenomes.org/id/BAA15398 EnsemblBacteria BAA15398 http://www.ensemblgenomes.org/id/BAA15398 EnsemblBacteria b1637 http://www.ensemblgenomes.org/id/b1637 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0004831 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004831 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006437 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006437 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 Gene3D 3.10.290.10 http://www.cathdb.info/version/latest/superfamily/3.10.290.10 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 GeneID 948855 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948855 HAMAP MF_02006 http://hamap.expasy.org/unirule/MF_02006 HOGENOM HOG000242790 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000242790&db=HOGENOM6 InParanoid P0AGJ9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGJ9 IntAct P0AGJ9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AGJ9* IntEnz 6.1.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.1.1.1 InterPro IPR001412 http://www.ebi.ac.uk/interpro/entry/IPR001412 InterPro IPR002305 http://www.ebi.ac.uk/interpro/entry/IPR002305 InterPro IPR002307 http://www.ebi.ac.uk/interpro/entry/IPR002307 InterPro IPR002942 http://www.ebi.ac.uk/interpro/entry/IPR002942 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 InterPro IPR024088 http://www.ebi.ac.uk/interpro/entry/IPR024088 InterPro IPR024107 http://www.ebi.ac.uk/interpro/entry/IPR024107 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW1629 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1629 KEGG_Gene eco:b1637 http://www.genome.jp/dbget-bin/www_bget?eco:b1637 KEGG_Orthology KO:K01866 http://www.genome.jp/dbget-bin/www_bget?KO:K01866 KEGG_Pathway ko00970 http://www.genome.jp/kegg-bin/show_pathway?ko00970 KEGG_Reaction rn:R02918 http://www.genome.jp/dbget-bin/www_bget?rn:R02918 MINT MINT-1224558 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1224558 OMA GKHFPVN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GKHFPVN PANTHER PTHR11766 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11766 PDB 1VBM http://www.ebi.ac.uk/pdbe-srv/view/entry/1VBM PDB 1VBN http://www.ebi.ac.uk/pdbe-srv/view/entry/1VBN PDB 1WQ3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1WQ3 PDB 1WQ4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1WQ4 PDB 1X8X http://www.ebi.ac.uk/pdbe-srv/view/entry/1X8X PDB 2YXN http://www.ebi.ac.uk/pdbe-srv/view/entry/2YXN PDBsum 1VBM http://www.ebi.ac.uk/pdbsum/1VBM PDBsum 1VBN http://www.ebi.ac.uk/pdbsum/1VBN PDBsum 1WQ3 http://www.ebi.ac.uk/pdbsum/1WQ3 PDBsum 1WQ4 http://www.ebi.ac.uk/pdbsum/1WQ4 PDBsum 1X8X http://www.ebi.ac.uk/pdbsum/1X8X PDBsum 2YXN http://www.ebi.ac.uk/pdbsum/2YXN PRINTS PR01040 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01040 PROSITE PS00178 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00178 PROSITE PS50889 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50889 PSORT swissprot:SYY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SYY_ECOLI PSORT-B swissprot:SYY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SYY_ECOLI PSORT2 swissprot:SYY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SYY_ECOLI Pfam PF00579 http://pfam.xfam.org/family/PF00579 Pfam PF01479 http://pfam.xfam.org/family/PF01479 Phobius swissprot:SYY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SYY_ECOLI PhylomeDB P0AGJ9 http://phylomedb.org/?seqid=P0AGJ9 ProteinModelPortal P0AGJ9 http://www.proteinmodelportal.org/query/uniprot/P0AGJ9 PubMed 1356963 http://www.ncbi.nlm.nih.gov/pubmed/1356963 PubMed 15663931 http://www.ncbi.nlm.nih.gov/pubmed/15663931 PubMed 15671170 http://www.ncbi.nlm.nih.gov/pubmed/15671170 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 6761148 http://www.ncbi.nlm.nih.gov/pubmed/6761148 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_416154 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416154 RefSeq WP_001295400 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295400 SMART SM00363 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00363 SMR P0AGJ9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AGJ9 STRING 511145.b1637 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1637&targetmode=cogs STRING COG0162 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0162&targetmode=cogs SWISS-2DPAGE P0AGJ9 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AGJ9 TIGRFAMs TIGR00234 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00234 UniProtKB SYY_ECOLI http://www.uniprot.org/uniprot/SYY_ECOLI UniProtKB-AC P0AGJ9 http://www.uniprot.org/uniprot/P0AGJ9 charge swissprot:SYY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SYY_ECOLI eggNOG COG0162 http://eggnogapi.embl.de/nog_data/html/tree/COG0162 eggNOG ENOG4105DA0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DA0 epestfind swissprot:SYY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SYY_ECOLI garnier swissprot:SYY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SYY_ECOLI helixturnhelix swissprot:SYY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SYY_ECOLI hmoment swissprot:SYY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SYY_ECOLI iep swissprot:SYY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SYY_ECOLI inforesidue swissprot:SYY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SYY_ECOLI octanol swissprot:SYY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SYY_ECOLI pepcoil swissprot:SYY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SYY_ECOLI pepdigest swissprot:SYY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SYY_ECOLI pepinfo swissprot:SYY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SYY_ECOLI pepnet swissprot:SYY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SYY_ECOLI pepstats swissprot:SYY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SYY_ECOLI pepwheel swissprot:SYY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SYY_ECOLI pepwindow swissprot:SYY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SYY_ECOLI sigcleave swissprot:SYY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SYY_ECOLI ## Database ID URL or Descriptions # BioGrid 4261962 9 # EcoGene EG12320 yadG # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016887 ATPase activity; IEA:InterPro. # GO_process GO:0006810 transport; IEA:UniProtKB-KW. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # Gene3D 3.40.50.300 -; 1. # IntAct P36879 5 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00248 Putative antibiotic transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism YADG_ECOLI Escherichia coli (strain K12) # PATRIC 32115357 VBIEscCol129921_0130 # PIR S45204 S45204 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # Pfam PF00005 ABC_tran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YADG_ECOLI Uncharacterized ABC transporter ATP-binding protein YadG # RefSeq NP_414669 NC_000913.3 # RefSeq WP_000150637 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA # SUPFAM SSF52540 SSF52540 # TCDB 3.A.1.105.17 the atp-binding cassette (abc) superfamily # eggNOG COG1131 LUCA # eggNOG ENOG4105DA5 Bacteria BLAST swissprot:YADG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YADG_ECOLI BioCyc ECOL316407:JW0123-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0123-MONOMER BioCyc EcoCyc:YADG-MONOMER http://biocyc.org/getid?id=EcoCyc:YADG-MONOMER COG COG1131 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1131 DIP DIP-11185N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11185N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2225 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2225 EcoGene EG12320 http://www.ecogene.org/geneInfo.php?eg_id=EG12320 EnsemblBacteria AAC73238 http://www.ensemblgenomes.org/id/AAC73238 EnsemblBacteria AAC73238 http://www.ensemblgenomes.org/id/AAC73238 EnsemblBacteria BAB96703 http://www.ensemblgenomes.org/id/BAB96703 EnsemblBacteria BAB96703 http://www.ensemblgenomes.org/id/BAB96703 EnsemblBacteria BAB96703 http://www.ensemblgenomes.org/id/BAB96703 EnsemblBacteria b0127 http://www.ensemblgenomes.org/id/b0127 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 944833 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944833 InParanoid P36879 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P36879 IntAct P36879 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P36879* InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0123 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0123 KEGG_Gene eco:b0127 http://www.genome.jp/dbget-bin/www_bget?eco:b0127 KEGG_Orthology KO:K09687 http://www.genome.jp/dbget-bin/www_bget?KO:K09687 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 MINT MINT-1289416 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1289416 OMA NIGIIQR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NIGIIQR PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:YADG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YADG_ECOLI PSORT-B swissprot:YADG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YADG_ECOLI PSORT2 swissprot:YADG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YADG_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Phobius swissprot:YADG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YADG_ECOLI PhylomeDB P36879 http://phylomedb.org/?seqid=P36879 ProteinModelPortal P36879 http://www.proteinmodelportal.org/query/uniprot/P36879 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414669 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414669 RefSeq WP_000150637 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000150637 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P36879 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P36879 STRING 511145.b0127 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0127&targetmode=cogs STRING COG1131 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1131&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.105.17 http://www.tcdb.org/search/result.php?tc=3.A.1.105.17 UniProtKB YADG_ECOLI http://www.uniprot.org/uniprot/YADG_ECOLI UniProtKB-AC P36879 http://www.uniprot.org/uniprot/P36879 charge swissprot:YADG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YADG_ECOLI eggNOG COG1131 http://eggnogapi.embl.de/nog_data/html/tree/COG1131 eggNOG ENOG4105DA5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DA5 epestfind swissprot:YADG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YADG_ECOLI garnier swissprot:YADG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YADG_ECOLI helixturnhelix swissprot:YADG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YADG_ECOLI hmoment swissprot:YADG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YADG_ECOLI iep swissprot:YADG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YADG_ECOLI inforesidue swissprot:YADG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YADG_ECOLI octanol swissprot:YADG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YADG_ECOLI pepcoil swissprot:YADG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YADG_ECOLI pepdigest swissprot:YADG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YADG_ECOLI pepinfo swissprot:YADG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YADG_ECOLI pepnet swissprot:YADG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YADG_ECOLI pepstats swissprot:YADG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YADG_ECOLI pepwheel swissprot:YADG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YADG_ECOLI pepwindow swissprot:YADG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YADG_ECOLI sigcleave swissprot:YADG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YADG_ECOLI ## Database ID URL or Descriptions # BioGrid 4260198 4 # EcoGene EG13775 yncE # GO_component GO:0030288 outer membrane-bounded periplasmic space; IGI:EcoCyc. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003677 DNA binding # Gene3D 2.130.10.10 -; 1. # INDUCTION Repressed by Fur. {ECO:0000269|PubMed 12746439}. # IntAct P76116 4 # InterPro IPR011048 Haem_d1 # InterPro IPR015943 WD40/YVTN_repeat-like_dom # MISCELLANEOUS YNCE_ECOLI Preliminary crystallization indicates the presence of a single beta-propeller domain that contains 7 4-stranded beta- sheets. # Organism YNCE_ECOLI Escherichia coli (strain K12) # PATRIC 32118196 VBIEscCol129921_1518 # PDB 3VGZ X-ray; 1.70 A; A/B/C/D=1-353 # PDB 3VH0 X-ray; 2.90 A; A/B/C/D=1-353 # PIR G64897 G64897 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNCE_ECOLI Uncharacterized protein YncE # RefSeq NP_415969 NC_000913.3 # RefSeq WP_000550695 NZ_LN832404.1 # SUBUNIT Monomer. {ECO:0000269|PubMed 18931447}. # SUPFAM SSF51004 SSF51004 # eggNOG COG3391 LUCA # eggNOG ENOG4108NS2 Bacteria BLAST swissprot:YNCE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNCE_ECOLI BioCyc ECOL316407:JW1447-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1447-MONOMER BioCyc EcoCyc:G6763-MONOMER http://biocyc.org/getid?id=EcoCyc:G6763-MONOMER DIP DIP-28079N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-28079N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M303381200 http://dx.doi.org/10.1074/jbc.M303381200 DOI 10.1074/jbc.M509929200 http://dx.doi.org/10.1074/jbc.M509929200 DOI 10.1107/S1744309108029515 http://dx.doi.org/10.1107/S1744309108029515 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3537 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3537 EcoGene EG13775 http://www.ecogene.org/geneInfo.php?eg_id=EG13775 EnsemblBacteria AAC74534 http://www.ensemblgenomes.org/id/AAC74534 EnsemblBacteria AAC74534 http://www.ensemblgenomes.org/id/AAC74534 EnsemblBacteria BAE76445 http://www.ensemblgenomes.org/id/BAE76445 EnsemblBacteria BAE76445 http://www.ensemblgenomes.org/id/BAE76445 EnsemblBacteria BAE76445 http://www.ensemblgenomes.org/id/BAE76445 EnsemblBacteria b1452 http://www.ensemblgenomes.org/id/b1452 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 Gene3D 2.130.10.10 http://www.cathdb.info/version/latest/superfamily/2.130.10.10 GeneID 946006 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946006 HOGENOM HOG000120631 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120631&db=HOGENOM6 InParanoid P76116 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76116 IntAct P76116 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76116* InterPro IPR011048 http://www.ebi.ac.uk/interpro/entry/IPR011048 InterPro IPR015943 http://www.ebi.ac.uk/interpro/entry/IPR015943 KEGG_Gene ecj:JW1447 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1447 KEGG_Gene eco:b1452 http://www.genome.jp/dbget-bin/www_bget?eco:b1452 OMA QDDGKEH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QDDGKEH PDB 3VGZ http://www.ebi.ac.uk/pdbe-srv/view/entry/3VGZ PDB 3VH0 http://www.ebi.ac.uk/pdbe-srv/view/entry/3VH0 PDBsum 3VGZ http://www.ebi.ac.uk/pdbsum/3VGZ PDBsum 3VH0 http://www.ebi.ac.uk/pdbsum/3VH0 PSORT swissprot:YNCE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNCE_ECOLI PSORT-B swissprot:YNCE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNCE_ECOLI PSORT2 swissprot:YNCE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNCE_ECOLI Phobius swissprot:YNCE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNCE_ECOLI PhylomeDB P76116 http://phylomedb.org/?seqid=P76116 ProteinModelPortal P76116 http://www.proteinmodelportal.org/query/uniprot/P76116 PubMed 12746439 http://www.ncbi.nlm.nih.gov/pubmed/12746439 PubMed 16352602 http://www.ncbi.nlm.nih.gov/pubmed/16352602 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18931447 http://www.ncbi.nlm.nih.gov/pubmed/18931447 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415969 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415969 RefSeq WP_000550695 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000550695 SMR P76116 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76116 STRING 511145.b1452 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1452&targetmode=cogs SUPFAM SSF51004 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51004 UniProtKB YNCE_ECOLI http://www.uniprot.org/uniprot/YNCE_ECOLI UniProtKB-AC P76116 http://www.uniprot.org/uniprot/P76116 charge swissprot:YNCE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNCE_ECOLI eggNOG COG3391 http://eggnogapi.embl.de/nog_data/html/tree/COG3391 eggNOG ENOG4108NS2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108NS2 epestfind swissprot:YNCE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNCE_ECOLI garnier swissprot:YNCE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNCE_ECOLI helixturnhelix swissprot:YNCE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNCE_ECOLI hmoment swissprot:YNCE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNCE_ECOLI iep swissprot:YNCE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNCE_ECOLI inforesidue swissprot:YNCE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNCE_ECOLI octanol swissprot:YNCE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNCE_ECOLI pepcoil swissprot:YNCE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNCE_ECOLI pepdigest swissprot:YNCE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNCE_ECOLI pepinfo swissprot:YNCE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNCE_ECOLI pepnet swissprot:YNCE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNCE_ECOLI pepstats swissprot:YNCE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNCE_ECOLI pepwheel swissprot:YNCE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNCE_ECOLI pepwindow swissprot:YNCE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNCE_ECOLI sigcleave swissprot:YNCE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNCE_ECOLI ## Database ID URL or Descriptions # BioGrid 4260759 137 # EcoGene EG13681 ybjL # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0008324 cation transmembrane transporter activity; IEA:InterPro. # GO_function GO:0015459 potassium channel regulator activity; IEA:UniProtKB-HAMAP. # GO_process GO:0006813 potassium ion transport; IEA:InterPro. # GO_process GO:0043266 regulation of potassium ion transport; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # Gene3D 3.30.70.1450 -; 2. # HAMAP MF_01015 YbjL # InterPro IPR006037 RCK_C # InterPro IPR006512 YidE_YbjL # InterPro IPR023017 Transp_YbjL_put # Organism YBJL_ECOLI Escherichia coli (strain K12) # PATRIC 32116899 VBIEscCol129921_0875 # PIR G64822 G64822 # PROSITE PS51202 RCK_C; 2 # Pfam PF02080 TrkA_C; 2 # Pfam PF06826 Asp-Al_Ex; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Putative transport protein YbjL {ECO:0000255|HAMAP-Rule MF_01015} # RefSeq NP_415368 NC_000913.3 # RefSeq WP_001024876 NZ_CP014272.1 # SIMILARITY Belongs to the AAE transporter (TC 2.A.81) family. YbjL subfamily. {ECO:0000255|HAMAP-Rule MF_01015}. # SIMILARITY Contains 2 RCK C-terminal domains. {ECO:0000255|HAMAP- Rule MF_01015}. # SUBCELLULAR LOCATION YBJL_ECOLI Cell membrane {ECO 0000255|HAMAP- Rule MF_01015}; Multi-pass membrane protein {ECO 0000255|HAMAP- Rule MF_01015}. # SUPFAM SSF116726 SSF116726; 2 # TIGRFAMs TIGR01625 YidE_YbjL_dupl; 2 # eggNOG COG2985 LUCA # eggNOG ENOG4105D0C Bacteria BLAST swissprot:YBJL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBJL_ECOLI BioCyc ECOL316407:JW0831-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0831-MONOMER BioCyc EcoCyc:G6445-MONOMER http://biocyc.org/getid?id=EcoCyc:G6445-MONOMER COG COG2985 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2985 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D38308 http://www.ebi.ac.uk/ena/data/view/D38308 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3445 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3445 EcoGene EG13681 http://www.ecogene.org/geneInfo.php?eg_id=EG13681 EnsemblBacteria AAC73934 http://www.ensemblgenomes.org/id/AAC73934 EnsemblBacteria AAC73934 http://www.ensemblgenomes.org/id/AAC73934 EnsemblBacteria BAA35551 http://www.ensemblgenomes.org/id/BAA35551 EnsemblBacteria BAA35551 http://www.ensemblgenomes.org/id/BAA35551 EnsemblBacteria BAA35551 http://www.ensemblgenomes.org/id/BAA35551 EnsemblBacteria b0847 http://www.ensemblgenomes.org/id/b0847 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008324 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008324 GO_function GO:0015459 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015459 GO_process GO:0006813 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813 GO_process GO:0043266 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043266 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.30.70.1450 http://www.cathdb.info/version/latest/superfamily/3.30.70.1450 GeneID 945474 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945474 HAMAP MF_01015 http://hamap.expasy.org/unirule/MF_01015 HOGENOM HOG000218047 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218047&db=HOGENOM6 InParanoid P60869 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P60869 InterPro IPR006037 http://www.ebi.ac.uk/interpro/entry/IPR006037 InterPro IPR006512 http://www.ebi.ac.uk/interpro/entry/IPR006512 InterPro IPR023017 http://www.ebi.ac.uk/interpro/entry/IPR023017 KEGG_Gene ecj:JW0831 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0831 KEGG_Gene eco:b0847 http://www.genome.jp/dbget-bin/www_bget?eco:b0847 KEGG_Orthology KO:K07085 http://www.genome.jp/dbget-bin/www_bget?KO:K07085 OMA RDGKNYF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RDGKNYF PROSITE PS51202 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51202 PSORT swissprot:YBJL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBJL_ECOLI PSORT-B swissprot:YBJL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBJL_ECOLI PSORT2 swissprot:YBJL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBJL_ECOLI Pfam PF02080 http://pfam.xfam.org/family/PF02080 Pfam PF06826 http://pfam.xfam.org/family/PF06826 Phobius swissprot:YBJL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBJL_ECOLI PhylomeDB P60869 http://phylomedb.org/?seqid=P60869 ProteinModelPortal P60869 http://www.proteinmodelportal.org/query/uniprot/P60869 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8755878 http://www.ncbi.nlm.nih.gov/pubmed/8755878 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415368 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415368 RefSeq WP_001024876 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001024876 SMR P60869 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P60869 STRING 511145.b0847 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0847&targetmode=cogs STRING COG2985 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2985&targetmode=cogs SUPFAM SSF116726 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF116726 TIGRFAMs TIGR01625 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01625 UniProtKB YBJL_ECOLI http://www.uniprot.org/uniprot/YBJL_ECOLI UniProtKB-AC P60869 http://www.uniprot.org/uniprot/P60869 charge swissprot:YBJL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBJL_ECOLI eggNOG COG2985 http://eggnogapi.embl.de/nog_data/html/tree/COG2985 eggNOG ENOG4105D0C http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D0C epestfind swissprot:YBJL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBJL_ECOLI garnier swissprot:YBJL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBJL_ECOLI helixturnhelix swissprot:YBJL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBJL_ECOLI hmoment swissprot:YBJL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBJL_ECOLI iep swissprot:YBJL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBJL_ECOLI inforesidue swissprot:YBJL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBJL_ECOLI octanol swissprot:YBJL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBJL_ECOLI pepcoil swissprot:YBJL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBJL_ECOLI pepdigest swissprot:YBJL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBJL_ECOLI pepinfo swissprot:YBJL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBJL_ECOLI pepnet swissprot:YBJL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBJL_ECOLI pepstats swissprot:YBJL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBJL_ECOLI pepwheel swissprot:YBJL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBJL_ECOLI pepwindow swissprot:YBJL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBJL_ECOLI sigcleave swissprot:YBJL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBJL_ECOLI ## Database ID URL or Descriptions # BioGrid 4263130 12 # DISRUPTION PHENOTYPE Cells lacking this gene show an increased lysogenization frequency. {ECO:0000269|PubMed 11278968}. # EcoGene EG11345 hflD # FUNCTION HFLD_ECOLI Negative regulator of phage lambda lysogenization. Contributes to the degradation of the phage regulatory protein CII. Acts probably by holding CII on the membrane surface, away from the target promoters, but close to the FtsH protease. {ECO 0000269|PubMed 11278968}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0031234 extrinsic component of cytoplasmic side of plasma membrane; IDA:EcoCyc. # GO_process GO:0009408 response to heat; IEP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006950 response to stress # Gene3D 1.10.3890.10 -; 1. # HAMAP MF_00695 HflD_protein # InterPro IPR007451 UPF0274 # Organism HFLD_ECOLI Escherichia coli (strain K12) # PATRIC 32117513 VBIEscCol129921_1179 # PDB 1QZ4 X-ray; 2.00 A; A=2-213 # PDB 1SDI X-ray; 1.65 A; A=2-213 # PIR S19211 S19211 # Pfam PF04356 DUF489 # ProDom PD037115 UPF0274 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HFLD_ECOLI High frequency lysogenization protein HflD # RefSeq NP_415650 NC_000913.3 # RefSeq WP_001297479 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=M74924; Type=Frameshift; Positions=49, 174, 178; Evidence={ECO 0000305}; # SIMILARITY Belongs to the HflD family. {ECO 0000305}. # SUBCELLULAR LOCATION HFLD_ECOLI Cytoplasm {ECO 0000269|PubMed 11278968}. Cell inner membrane {ECO 0000269|PubMed 11278968}; Peripheral membrane protein {ECO 0000269|PubMed 11278968}; Cytoplasmic side {ECO 0000269|PubMed 11278968}. # SUBUNIT Interacts with CII protein from phage lambda. {ECO:0000269|PubMed 11278968}. # SUPFAM SSF101322 SSF101322 # eggNOG COG2915 LUCA # eggNOG ENOG41075W9 Bacteria BLAST swissprot:HFLD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HFLD_ECOLI BioCyc ECOL316407:JW5165-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5165-MONOMER BioCyc EcoCyc:EG11345-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11345-MONOMER COG COG2915 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2915 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M011699200 http://dx.doi.org/10.1074/jbc.M011699200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1099/13500872-142-11-3219 http://dx.doi.org/10.1099/13500872-142-11-3219 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M74924 http://www.ebi.ac.uk/ena/data/view/M74924 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X59307 http://www.ebi.ac.uk/ena/data/view/X59307 EchoBASE EB1321 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1321 EcoGene EG11345 http://www.ecogene.org/geneInfo.php?eg_id=EG11345 EnsemblBacteria AAC74216 http://www.ensemblgenomes.org/id/AAC74216 EnsemblBacteria AAC74216 http://www.ensemblgenomes.org/id/AAC74216 EnsemblBacteria BAA35954 http://www.ensemblgenomes.org/id/BAA35954 EnsemblBacteria BAA35954 http://www.ensemblgenomes.org/id/BAA35954 EnsemblBacteria BAA35954 http://www.ensemblgenomes.org/id/BAA35954 EnsemblBacteria b1132 http://www.ensemblgenomes.org/id/b1132 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0031234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031234 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 1.10.3890.10 http://www.cathdb.info/version/latest/superfamily/1.10.3890.10 GeneID 945693 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945693 HAMAP MF_00695 http://hamap.expasy.org/unirule/MF_00695 HOGENOM HOG000119128 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000119128&db=HOGENOM6 InParanoid P25746 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P25746 InterPro IPR007451 http://www.ebi.ac.uk/interpro/entry/IPR007451 KEGG_Gene ecj:JW5165 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5165 KEGG_Gene eco:b1132 http://www.genome.jp/dbget-bin/www_bget?eco:b1132 KEGG_Orthology KO:K07153 http://www.genome.jp/dbget-bin/www_bget?KO:K07153 OMA RSAVLWH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RSAVLWH PDB 1QZ4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1QZ4 PDB 1SDI http://www.ebi.ac.uk/pdbe-srv/view/entry/1SDI PDBsum 1QZ4 http://www.ebi.ac.uk/pdbsum/1QZ4 PDBsum 1SDI http://www.ebi.ac.uk/pdbsum/1SDI PSORT swissprot:HFLD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HFLD_ECOLI PSORT-B swissprot:HFLD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HFLD_ECOLI PSORT2 swissprot:HFLD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HFLD_ECOLI Pfam PF04356 http://pfam.xfam.org/family/PF04356 Phobius swissprot:HFLD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HFLD_ECOLI ProteinModelPortal P25746 http://www.proteinmodelportal.org/query/uniprot/P25746 PubMed 11278968 http://www.ncbi.nlm.nih.gov/pubmed/11278968 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1729205 http://www.ncbi.nlm.nih.gov/pubmed/1729205 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 8969519 http://www.ncbi.nlm.nih.gov/pubmed/8969519 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415650 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415650 RefSeq WP_001297479 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001297479 SMR P25746 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P25746 STRING 511145.b1132 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1132&targetmode=cogs STRING COG2915 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2915&targetmode=cogs SUPFAM SSF101322 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF101322 UniProtKB HFLD_ECOLI http://www.uniprot.org/uniprot/HFLD_ECOLI UniProtKB-AC P25746 http://www.uniprot.org/uniprot/P25746 charge swissprot:HFLD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HFLD_ECOLI eggNOG COG2915 http://eggnogapi.embl.de/nog_data/html/tree/COG2915 eggNOG ENOG41075W9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41075W9 epestfind swissprot:HFLD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HFLD_ECOLI garnier swissprot:HFLD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HFLD_ECOLI helixturnhelix swissprot:HFLD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HFLD_ECOLI hmoment swissprot:HFLD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HFLD_ECOLI iep swissprot:HFLD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HFLD_ECOLI inforesidue swissprot:HFLD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HFLD_ECOLI octanol swissprot:HFLD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HFLD_ECOLI pepcoil swissprot:HFLD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HFLD_ECOLI pepdigest swissprot:HFLD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HFLD_ECOLI pepinfo swissprot:HFLD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HFLD_ECOLI pepnet swissprot:HFLD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HFLD_ECOLI pepstats swissprot:HFLD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HFLD_ECOLI pepwheel swissprot:HFLD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HFLD_ECOLI pepwindow swissprot:HFLD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HFLD_ECOLI sigcleave swissprot:HFLD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HFLD_ECOLI ## Database ID URL or Descriptions # BioGrid 4261684 8 # EcoGene EG12106 hofB # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0006276 plasmid maintenance; IMP:EcoCyc. # GO_process GO:0006810 transport; IEA:UniProtKB-KW. # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.300 -; 1. # IntAct P36645 5 # InterPro IPR001482 T2SS_protein-E # InterPro IPR007831 GSPII_E_N # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko02044 Secretion system # Organism HOFB_ECOLI Escherichia coli (strain K12) # PATRIC 32115315 VBIEscCol129921_0109 # PIR C64733 C64733 # PROSITE PS00662 T2SP_E # Pfam PF00437 T2SSE # Pfam PF05157 T2SSE_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HOFB_ECOLI Protein transport protein HofB homolog # RefSeq NP_414649 NC_000913.3 # RefSeq WP_001025145 NZ_LN832404.1 # SIMILARITY Belongs to the GSP E family. {ECO 0000305}. # SUPFAM SSF52540 SSF52540 # eggNOG COG2804 LUCA # eggNOG ENOG4107QHF Bacteria BLAST swissprot:HOFB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HOFB_ECOLI BioCyc ECOL316407:JW0103-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0103-MONOMER BioCyc EcoCyc:EG12106-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12106-MONOMER COG COG2804 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2804 DIP DIP-9919N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9919N DOI 10.1016/0378-1119(94)90851-6 http://dx.doi.org/10.1016/0378-1119(94)90851-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L20834 http://www.ebi.ac.uk/ena/data/view/L20834 EMBL L28105 http://www.ebi.ac.uk/ena/data/view/L28105 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2030 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2030 EcoGene EG12106 http://www.ecogene.org/geneInfo.php?eg_id=EG12106 EnsemblBacteria AAC73218 http://www.ensemblgenomes.org/id/AAC73218 EnsemblBacteria AAC73218 http://www.ensemblgenomes.org/id/AAC73218 EnsemblBacteria BAB96676 http://www.ensemblgenomes.org/id/BAB96676 EnsemblBacteria BAB96676 http://www.ensemblgenomes.org/id/BAB96676 EnsemblBacteria BAB96676 http://www.ensemblgenomes.org/id/BAB96676 EnsemblBacteria b0107 http://www.ensemblgenomes.org/id/b0107 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006276 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947481 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947481 HOGENOM HOG000008427 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000008427&db=HOGENOM6 InParanoid P36645 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P36645 IntAct P36645 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P36645* InterPro IPR001482 http://www.ebi.ac.uk/interpro/entry/IPR001482 InterPro IPR007831 http://www.ebi.ac.uk/interpro/entry/IPR007831 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW0103 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0103 KEGG_Gene eco:b0107 http://www.genome.jp/dbget-bin/www_bget?eco:b0107 KEGG_Orthology KO:K02504 http://www.genome.jp/dbget-bin/www_bget?KO:K02504 OMA WPRARIE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WPRARIE PROSITE PS00662 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00662 PSORT swissprot:HOFB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HOFB_ECOLI PSORT-B swissprot:HOFB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HOFB_ECOLI PSORT2 swissprot:HOFB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HOFB_ECOLI Pfam PF00437 http://pfam.xfam.org/family/PF00437 Pfam PF05157 http://pfam.xfam.org/family/PF05157 Phobius swissprot:HOFB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HOFB_ECOLI PhylomeDB P36645 http://phylomedb.org/?seqid=P36645 ProteinModelPortal P36645 http://www.proteinmodelportal.org/query/uniprot/P36645 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7959070 http://www.ncbi.nlm.nih.gov/pubmed/7959070 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414649 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414649 RefSeq WP_001025145 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001025145 SMR P36645 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P36645 STRING 511145.b0107 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0107&targetmode=cogs STRING COG2804 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2804&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB HOFB_ECOLI http://www.uniprot.org/uniprot/HOFB_ECOLI UniProtKB-AC P36645 http://www.uniprot.org/uniprot/P36645 charge swissprot:HOFB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HOFB_ECOLI eggNOG COG2804 http://eggnogapi.embl.de/nog_data/html/tree/COG2804 eggNOG ENOG4107QHF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QHF epestfind swissprot:HOFB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HOFB_ECOLI garnier swissprot:HOFB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HOFB_ECOLI helixturnhelix swissprot:HOFB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HOFB_ECOLI hmoment swissprot:HOFB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HOFB_ECOLI iep swissprot:HOFB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HOFB_ECOLI inforesidue swissprot:HOFB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HOFB_ECOLI octanol swissprot:HOFB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HOFB_ECOLI pepcoil swissprot:HOFB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HOFB_ECOLI pepdigest swissprot:HOFB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HOFB_ECOLI pepinfo swissprot:HOFB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HOFB_ECOLI pepnet swissprot:HOFB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HOFB_ECOLI pepstats swissprot:HOFB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HOFB_ECOLI pepwheel swissprot:HOFB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HOFB_ECOLI pepwindow swissprot:HOFB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HOFB_ECOLI sigcleave swissprot:HOFB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HOFB_ECOLI ## Database ID URL or Descriptions # AltName PHNN_ECOLI Ribose 1,5-bisphosphokinase # CATALYTIC ACTIVITY ATP + alpha-D-ribose 1,5-bisphosphate = ADP + 5-phospho-alpha-D-ribose 1-diphosphate. {ECO:0000269|PubMed 12700258}. # EcoGene EG10723 phnN # FUNCTION PHNN_ECOLI Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP). Accepts ATP but not GTP as a phosphoryl donor, and uses ribose 1,5-bisphosphate but not ribose, ribose 1-phosphate, or ribose 5-phosphate as a phosphoryl acceptor. {ECO 0000269|PubMed 12700258, ECO 0000269|PubMed 19733071}. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0033863 ribose 1,5-bisphosphate phosphokinase activity; IDA:UniProtKB. # GO_process GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process; IDA:UniProtKB. # GO_process GO:0019634 organic phosphonate metabolic process; IDA:UniProtKB. # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.300 -; 2. # HAMAP MF_00836 PhnN # IntAct P16690 33 # InterPro IPR008145 GK/Ca_channel_bsu # InterPro IPR012699 PhnN # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00030 Pentose phosphate pathway # Organism PHNN_ECOLI Escherichia coli (strain K12) # PATHWAY Metabolic intermediate biosynthesis; 5-phospho-alpha-D- ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1- diphosphate from D-ribose 5-phosphate (route II) step 3/3. # PATRIC 32123747 VBIEscCol129921_4222 # PIR F35719 F35719 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PHNN_ECOLI Ribose 1,5-bisphosphate phosphokinase PhnN # RefSeq NP_418518 NC_000913.3 # RefSeq WP_000971886 NZ_LN832404.1 # SIMILARITY Belongs to the ribose 1,5-bisphosphokinase family. {ECO 0000305}. # SMART SM00072 GuKc # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR02322 phosphon_PhnN # UniPathway UPA00087 UER00175 # eggNOG COG3709 LUCA # eggNOG ENOG4105MFQ Bacteria BLAST swissprot:PHNN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PHNN_ECOLI BioCyc ECOL316407:JW4055-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4055-MONOMER BioCyc EcoCyc:EG10723-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10723-MONOMER BioCyc MetaCyc:EG10723-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10723-MONOMER COG COG3709 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3709 DOI 10.1016/j.bmcl.2009.08.035 http://dx.doi.org/10.1016/j.bmcl.2009.08.035 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01131-09 http://dx.doi.org/10.1128/JB.01131-09 DOI 10.1128/JB.185.9.2793-2801.2003 http://dx.doi.org/10.1128/JB.185.9.2793-2801.2003 EC_number EC:2.7.4.23 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.4.23 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D90227 http://www.ebi.ac.uk/ena/data/view/D90227 EMBL J05260 http://www.ebi.ac.uk/ena/data/view/J05260 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 2.7.4.23 http://enzyme.expasy.org/EC/2.7.4.23 EchoBASE EB0717 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0717 EcoGene EG10723 http://www.ecogene.org/geneInfo.php?eg_id=EG10723 EnsemblBacteria AAC77055 http://www.ensemblgenomes.org/id/AAC77055 EnsemblBacteria AAC77055 http://www.ensemblgenomes.org/id/AAC77055 EnsemblBacteria BAE78097 http://www.ensemblgenomes.org/id/BAE78097 EnsemblBacteria BAE78097 http://www.ensemblgenomes.org/id/BAE78097 EnsemblBacteria BAE78097 http://www.ensemblgenomes.org/id/BAE78097 EnsemblBacteria b4094 http://www.ensemblgenomes.org/id/b4094 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0033863 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033863 GO_process GO:0006015 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006015 GO_process GO:0019634 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019634 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948608 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948608 HAMAP MF_00836 http://hamap.expasy.org/unirule/MF_00836 HOGENOM HOG000037637 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000037637&db=HOGENOM6 InParanoid P16690 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P16690 IntAct P16690 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P16690* IntEnz 2.7.4.23 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.4.23 InterPro IPR008145 http://www.ebi.ac.uk/interpro/entry/IPR008145 InterPro IPR012699 http://www.ebi.ac.uk/interpro/entry/IPR012699 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4055 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4055 KEGG_Gene eco:b4094 http://www.genome.jp/dbget-bin/www_bget?eco:b4094 KEGG_Orthology KO:K05774 http://www.genome.jp/dbget-bin/www_bget?KO:K05774 KEGG_Pathway ko00030 http://www.genome.jp/kegg-bin/show_pathway?ko00030 KEGG_Reaction rn:R06836 http://www.genome.jp/dbget-bin/www_bget?rn:R06836 OMA MARLIWL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MARLIWL PSORT swissprot:PHNN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PHNN_ECOLI PSORT-B swissprot:PHNN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PHNN_ECOLI PSORT2 swissprot:PHNN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PHNN_ECOLI Phobius swissprot:PHNN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PHNN_ECOLI PhylomeDB P16690 http://phylomedb.org/?seqid=P16690 ProteinModelPortal P16690 http://www.proteinmodelportal.org/query/uniprot/P16690 PubMed 12700258 http://www.ncbi.nlm.nih.gov/pubmed/12700258 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1840580 http://www.ncbi.nlm.nih.gov/pubmed/1840580 PubMed 19733071 http://www.ncbi.nlm.nih.gov/pubmed/19733071 PubMed 19854894 http://www.ncbi.nlm.nih.gov/pubmed/19854894 PubMed 2155230 http://www.ncbi.nlm.nih.gov/pubmed/2155230 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418518 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418518 RefSeq WP_000971886 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000971886 SMART SM00072 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00072 SMR P16690 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P16690 STRING 511145.b4094 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4094&targetmode=cogs STRING COG3709 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3709&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR02322 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02322 UniProtKB PHNN_ECOLI http://www.uniprot.org/uniprot/PHNN_ECOLI UniProtKB-AC P16690 http://www.uniprot.org/uniprot/P16690 charge swissprot:PHNN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PHNN_ECOLI eggNOG COG3709 http://eggnogapi.embl.de/nog_data/html/tree/COG3709 eggNOG ENOG4105MFQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105MFQ epestfind swissprot:PHNN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PHNN_ECOLI garnier swissprot:PHNN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PHNN_ECOLI helixturnhelix swissprot:PHNN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PHNN_ECOLI hmoment swissprot:PHNN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PHNN_ECOLI iep swissprot:PHNN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PHNN_ECOLI inforesidue swissprot:PHNN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PHNN_ECOLI octanol swissprot:PHNN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PHNN_ECOLI pepcoil swissprot:PHNN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PHNN_ECOLI pepdigest swissprot:PHNN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PHNN_ECOLI pepinfo swissprot:PHNN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PHNN_ECOLI pepnet swissprot:PHNN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PHNN_ECOLI pepstats swissprot:PHNN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PHNN_ECOLI pepwheel swissprot:PHNN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PHNN_ECOLI pepwindow swissprot:PHNN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PHNN_ECOLI sigcleave swissprot:PHNN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PHNN_ECOLI ## Database ID URL or Descriptions # AltName YAFO_ECOLI Endoribonuclease YafO # AltName YAFO_ECOLI Toxin YafO # BioGrid 4259763 133 # EcoGene EG13152 yafO # FUNCTION YAFO_ECOLI Toxic component of a toxin-antitoxin (TA) module. A translation-dependent mRNA interferase. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation; this blockage is overcome by subsequent expression of antitoxin YafN. Overexpression causes cleavage of a number of mRNAs in a ribosome-dependent fashion. YafO binding to the 50S ribosomal subunit in the translation complex induces mRNA cleavage 3' to the region protected by the ribosome; YafO alone is not able to digest mRNA. {ECO 0000269|PubMed 19617347, ECO 0000269|PubMed 19943910}. # GO_function GO:0003723 RNA binding; IEA:UniProtKB-KW. # GO_function GO:0004521 endoribonuclease activity; IDA:UniProtKB. # GO_function GO:0043023 ribosomal large subunit binding; IDA:EcoCyc. # GO_process GO:0006281 DNA repair; IEA:UniProtKB-KW. # GO_process GO:0009432 SOS response; IEA:UniProtKB-KW. # GO_process GO:0017148 negative regulation of translation; IDA:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0004518 nuclease activity # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # INDUCTION YAFO_ECOLI Induced by amino acid starvation, glucose starvation, the DNA cross-linker mitomycin C (SOS response) and when translation is blocked. Induction is decreased in the absence of the Lon protease suggesting, by homology to other toxin-antitoxin systems, that Lon may degrade the YafN antitoxin. Transcription is negatively regulated by the cognate locus, probably by YafN. A member of the dinB-yafNOP operon; it has 2 promoters, 1 upstream of dinB and 1 specific for yafN-yfaO. {ECO 0000269|PubMed 12813093, ECO 0000269|PubMed 19943910}. # IntAct Q47157 6 # InterPro IPR020353 Toxin_YafO # Organism YAFO_ECOLI Escherichia coli (strain K12) # PATRIC 32115581 VBIEscCol129921_0235 # PIR B64748 B64748 # Pfam PF13957 YafO_toxin # ProDom PD082093 Uncharacterised_YafO # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAFO_ECOLI mRNA interferase YafO # RefSeq NP_414768 NC_000913.3 # RefSeq WP_001263489 NZ_LN832404.1 # SUBUNIT Probably forms a complex with the antitoxin YafN which inhibits the mRNA interferase activity. {ECO 0000305}. # eggNOG ENOG41065DM Bacteria # eggNOG ENOG410XTZP LUCA BLAST swissprot:YAFO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAFO_ECOLI BioCyc ECOL316407:JW0223-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0223-MONOMER BioCyc EcoCyc:G6117-MONOMER http://biocyc.org/getid?id=EcoCyc:G6117-MONOMER BioCyc MetaCyc:G6117-MONOMER http://biocyc.org/getid?id=MetaCyc:G6117-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M109.036624 http://dx.doi.org/10.1074/jbc.M109.036624 DOI 10.1111/j.1365-2958.2009.06969.x http://dx.doi.org/10.1111/j.1365-2958.2009.06969.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.185.13.3972-3977.2003 http://dx.doi.org/10.1128/JB.185.13.3972-3977.2003 EC_number EC:3.1.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D38582 http://www.ebi.ac.uk/ena/data/view/D38582 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 ENZYME 3.1.-.- http://enzyme.expasy.org/EC/3.1.-.- EchoBASE EB2946 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2946 EcoGene EG13152 http://www.ecogene.org/geneInfo.php?eg_id=EG13152 EnsemblBacteria AAC73337 http://www.ensemblgenomes.org/id/AAC73337 EnsemblBacteria AAC73337 http://www.ensemblgenomes.org/id/AAC73337 EnsemblBacteria BAA77902 http://www.ensemblgenomes.org/id/BAA77902 EnsemblBacteria BAA77902 http://www.ensemblgenomes.org/id/BAA77902 EnsemblBacteria BAA77902 http://www.ensemblgenomes.org/id/BAA77902 EnsemblBacteria b0233 http://www.ensemblgenomes.org/id/b0233 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0004521 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004521 GO_function GO:0043023 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043023 GO_process GO:0006281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006281 GO_process GO:0009432 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009432 GO_process GO:0017148 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017148 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 944916 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944916 HOGENOM HOG000117057 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117057&db=HOGENOM6 IntAct Q47157 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q47157* IntEnz 3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1 InterPro IPR020353 http://www.ebi.ac.uk/interpro/entry/IPR020353 KEGG_Gene ecj:JW0223 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0223 KEGG_Gene eco:b0233 http://www.genome.jp/dbget-bin/www_bget?eco:b0233 OMA MSIRIFK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MSIRIFK PSORT swissprot:YAFO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAFO_ECOLI PSORT-B swissprot:YAFO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAFO_ECOLI PSORT2 swissprot:YAFO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAFO_ECOLI Pfam PF13957 http://pfam.xfam.org/family/PF13957 Phobius swissprot:YAFO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAFO_ECOLI ProteinModelPortal Q47157 http://www.proteinmodelportal.org/query/uniprot/Q47157 PubMed 12813093 http://www.ncbi.nlm.nih.gov/pubmed/12813093 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19617347 http://www.ncbi.nlm.nih.gov/pubmed/19617347 PubMed 19943910 http://www.ncbi.nlm.nih.gov/pubmed/19943910 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414768 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414768 RefSeq WP_001263489 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001263489 STRING 511145.b0233 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0233&targetmode=cogs UniProtKB YAFO_ECOLI http://www.uniprot.org/uniprot/YAFO_ECOLI UniProtKB-AC Q47157 http://www.uniprot.org/uniprot/Q47157 charge swissprot:YAFO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAFO_ECOLI eggNOG ENOG41065DM http://eggnogapi.embl.de/nog_data/html/tree/ENOG41065DM eggNOG ENOG410XTZP http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XTZP epestfind swissprot:YAFO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAFO_ECOLI garnier swissprot:YAFO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAFO_ECOLI helixturnhelix swissprot:YAFO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAFO_ECOLI hmoment swissprot:YAFO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAFO_ECOLI iep swissprot:YAFO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAFO_ECOLI inforesidue swissprot:YAFO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAFO_ECOLI octanol swissprot:YAFO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAFO_ECOLI pepcoil swissprot:YAFO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAFO_ECOLI pepdigest swissprot:YAFO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAFO_ECOLI pepinfo swissprot:YAFO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAFO_ECOLI pepnet swissprot:YAFO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAFO_ECOLI pepstats swissprot:YAFO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAFO_ECOLI pepwheel swissprot:YAFO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAFO_ECOLI pepwindow swissprot:YAFO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAFO_ECOLI sigcleave swissprot:YAFO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAFO_ECOLI ## Database ID URL or Descriptions # BioGrid 4259762 72 # EcoGene EG13151 yafN # FUNCTION YAFN_ECOLI Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin; overexpression prevents YafO-mediated cessation of cell growth and inhibition of cell proliferation. {ECO 0000269|PubMed 19617347, ECO 0000269|PubMed 19943910}. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006281 DNA repair; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IMP:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0009432 SOS response; IEA:UniProtKB-KW. # GO_process GO:0044092 negative regulation of molecular function; IDA:EcoCyc. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # INDUCTION YAFN_ECOLI Induced by amino acid starvation, glucose starvation, the DNA cross-linker mitomycin C (SOS response) and when translation is blocked. Induction is decreased in the absence of the Lon protease suggesting, by homology to other toxin-antitoxin systems, that Lon may degrade the YafN antitoxin. Transcription is negatively regulated by the cognate locus, probably by this protein. A member of the dinB-yafNOP operon; it has 2 promoters, 1 upstream of dinB and 1 specific for yafN-yfaO. {ECO 0000269|PubMed 12813093, ECO 0000269|PubMed 19943910}. # IntAct Q47156 2 # InterPro IPR006442 Antitoxin_Phd/YefM # Organism YAFN_ECOLI Escherichia coli (strain K12) # PATRIC 32115579 VBIEscCol129921_0234 # PIR A64748 A64748 # Pfam PF02604 PhdYeFM_antitox # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAFN_ECOLI Antitoxin YafN # RefSeq NP_414767 NC_000913.3 # RefSeq WP_000554758 NZ_LN832404.1 # SIMILARITY Belongs to the phD/YefM antitoxin family. {ECO 0000305}. # SUBUNIT Probably forms a complex with the mRNA interferase YafO which inhibits the mRNA interferase activity. {ECO 0000305}. # eggNOG COG2161 LUCA # eggNOG ENOG4105UG9 Bacteria BLAST swissprot:YAFN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAFN_ECOLI BioCyc ECOL316407:JW0222-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0222-MONOMER BioCyc EcoCyc:G6116-MONOMER http://biocyc.org/getid?id=EcoCyc:G6116-MONOMER DOI 10.1016/0165-7992(95)90024-1 http://dx.doi.org/10.1016/0165-7992(95)90024-1 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M109.036624 http://dx.doi.org/10.1074/jbc.M109.036624 DOI 10.1111/j.1365-2958.2009.06969.x http://dx.doi.org/10.1111/j.1365-2958.2009.06969.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.185.13.3972-3977.2003 http://dx.doi.org/10.1128/JB.185.13.3972-3977.2003 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D38582 http://www.ebi.ac.uk/ena/data/view/D38582 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EchoBASE EB2945 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2945 EcoGene EG13151 http://www.ecogene.org/geneInfo.php?eg_id=EG13151 EnsemblBacteria AAC73336 http://www.ensemblgenomes.org/id/AAC73336 EnsemblBacteria AAC73336 http://www.ensemblgenomes.org/id/AAC73336 EnsemblBacteria BAE76047 http://www.ensemblgenomes.org/id/BAE76047 EnsemblBacteria BAE76047 http://www.ensemblgenomes.org/id/BAE76047 EnsemblBacteria BAE76047 http://www.ensemblgenomes.org/id/BAE76047 EnsemblBacteria b0232 http://www.ensemblgenomes.org/id/b0232 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006281 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0009432 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009432 GO_process GO:0044092 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044092 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 944920 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944920 HOGENOM HOG000117056 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117056&db=HOGENOM6 InParanoid Q47156 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q47156 IntAct Q47156 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q47156* InterPro IPR006442 http://www.ebi.ac.uk/interpro/entry/IPR006442 KEGG_Gene ecj:JW0222 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0222 KEGG_Gene eco:b0232 http://www.genome.jp/dbget-bin/www_bget?eco:b0232 OMA NNKPAGY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NNKPAGY PSORT swissprot:YAFN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAFN_ECOLI PSORT-B swissprot:YAFN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAFN_ECOLI PSORT2 swissprot:YAFN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAFN_ECOLI Pfam PF02604 http://pfam.xfam.org/family/PF02604 Phobius swissprot:YAFN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAFN_ECOLI ProteinModelPortal Q47156 http://www.proteinmodelportal.org/query/uniprot/Q47156 PubMed 12813093 http://www.ncbi.nlm.nih.gov/pubmed/12813093 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19617347 http://www.ncbi.nlm.nih.gov/pubmed/19617347 PubMed 19943910 http://www.ncbi.nlm.nih.gov/pubmed/19943910 PubMed 7596361 http://www.ncbi.nlm.nih.gov/pubmed/7596361 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414767 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414767 RefSeq WP_000554758 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000554758 STRING 511145.b0232 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0232&targetmode=cogs UniProtKB YAFN_ECOLI http://www.uniprot.org/uniprot/YAFN_ECOLI UniProtKB-AC Q47156 http://www.uniprot.org/uniprot/Q47156 charge swissprot:YAFN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAFN_ECOLI eggNOG COG2161 http://eggnogapi.embl.de/nog_data/html/tree/COG2161 eggNOG ENOG4105UG9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105UG9 epestfind swissprot:YAFN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAFN_ECOLI garnier swissprot:YAFN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAFN_ECOLI helixturnhelix swissprot:YAFN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAFN_ECOLI hmoment swissprot:YAFN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAFN_ECOLI iep swissprot:YAFN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAFN_ECOLI inforesidue swissprot:YAFN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAFN_ECOLI octanol swissprot:YAFN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAFN_ECOLI pepcoil swissprot:YAFN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAFN_ECOLI pepdigest swissprot:YAFN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAFN_ECOLI pepinfo swissprot:YAFN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAFN_ECOLI pepnet swissprot:YAFN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAFN_ECOLI pepstats swissprot:YAFN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAFN_ECOLI pepwheel swissprot:YAFN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAFN_ECOLI pepwindow swissprot:YAFN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAFN_ECOLI sigcleave swissprot:YAFN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAFN_ECOLI ## Database ID URL or Descriptions # BioGrid 4261691 134 # CDD cd06174 MFS # EcoGene EG11242 ycaD # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005215 transporter activity; IEA:UniProtKB-HAMAP. # GO_process GO:0055085 transmembrane transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0055085 transmembrane transport # HAMAP MF_01149 MFS_YcaD # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # InterPro IPR023745 MFS_YcaD # KEGG_Brite ko02000 Transporters # Organism YCAD_ECOLI Escherichia coli (strain K12) # PATRIC 32117009 VBIEscCol129921_0929 # PIR A64829 A64829 # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCAD_ECOLI Uncharacterized MFS-type transporter YcaD # RefSeq NP_415418 NC_000913.3 # RefSeq WP_000109259 NZ_LN832404.1 # SIMILARITY Belongs to the major facilitator superfamily. YcaD (TC 2.A.1.26) family. {ECO 0000305}. # SUBCELLULAR LOCATION YCAD_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.26 the major facilitator superfamily (mfs) # eggNOG ENOG4108ISG Bacteria # eggNOG ENOG410Y0GE LUCA BLAST swissprot:YCAD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCAD_ECOLI BioCyc ECOL316407:JW0881-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0881-MONOMER BioCyc EcoCyc:YCAD-MONOMER http://biocyc.org/getid?id=EcoCyc:YCAD-MONOMER COG COG0477 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0477 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1988.tb00090.x http://dx.doi.org/10.1111/j.1365-2958.1988.tb00090.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J03412 http://www.ebi.ac.uk/ena/data/view/J03412 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1224 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1224 EcoGene EG11242 http://www.ecogene.org/geneInfo.php?eg_id=EG11242 EnsemblBacteria AAC73984 http://www.ensemblgenomes.org/id/AAC73984 EnsemblBacteria AAC73984 http://www.ensemblgenomes.org/id/AAC73984 EnsemblBacteria BAA35630 http://www.ensemblgenomes.org/id/BAA35630 EnsemblBacteria BAA35630 http://www.ensemblgenomes.org/id/BAA35630 EnsemblBacteria BAA35630 http://www.ensemblgenomes.org/id/BAA35630 EnsemblBacteria b0898 http://www.ensemblgenomes.org/id/b0898 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 945515 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945515 HAMAP MF_01149 http://hamap.expasy.org/unirule/MF_01149 HOGENOM HOG000280030 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000280030&db=HOGENOM6 InParanoid P21503 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P21503 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 InterPro IPR023745 http://www.ebi.ac.uk/interpro/entry/IPR023745 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0881 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0881 KEGG_Gene eco:b0898 http://www.genome.jp/dbget-bin/www_bget?eco:b0898 KEGG_Orthology KO:K08219 http://www.genome.jp/dbget-bin/www_bget?KO:K08219 OMA YWMALLI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YWMALLI PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:YCAD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCAD_ECOLI PSORT-B swissprot:YCAD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCAD_ECOLI PSORT2 swissprot:YCAD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCAD_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:YCAD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCAD_ECOLI PhylomeDB P21503 http://phylomedb.org/?seqid=P21503 ProteinModelPortal P21503 http://www.proteinmodelportal.org/query/uniprot/P21503 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3062312 http://www.ncbi.nlm.nih.gov/pubmed/3062312 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415418 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415418 RefSeq WP_000109259 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000109259 STRING 511145.b0898 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0898&targetmode=cogs STRING COG0477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0477&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.26 http://www.tcdb.org/search/result.php?tc=2.A.1.26 UniProtKB YCAD_ECOLI http://www.uniprot.org/uniprot/YCAD_ECOLI UniProtKB-AC P21503 http://www.uniprot.org/uniprot/P21503 charge swissprot:YCAD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCAD_ECOLI eggNOG ENOG4108ISG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ISG eggNOG ENOG410Y0GE http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y0GE epestfind swissprot:YCAD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCAD_ECOLI garnier swissprot:YCAD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCAD_ECOLI helixturnhelix swissprot:YCAD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCAD_ECOLI hmoment swissprot:YCAD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCAD_ECOLI iep swissprot:YCAD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCAD_ECOLI inforesidue swissprot:YCAD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCAD_ECOLI octanol swissprot:YCAD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCAD_ECOLI pepcoil swissprot:YCAD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCAD_ECOLI pepdigest swissprot:YCAD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCAD_ECOLI pepinfo swissprot:YCAD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCAD_ECOLI pepnet swissprot:YCAD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCAD_ECOLI pepstats swissprot:YCAD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCAD_ECOLI pepwheel swissprot:YCAD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCAD_ECOLI pepwindow swissprot:YCAD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCAD_ECOLI sigcleave swissprot:YCAD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCAD_ECOLI ## Database ID URL or Descriptions # BioGrid 4261401 38 # CATALYTIC ACTIVITY HRPB_ECOLI ATP + H(2)O = ADP + phosphate. # EcoGene EG12329 hrpB # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0004004 ATP-dependent RNA helicase activity; IBA:GO_Central. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0044822 poly(A) RNA binding; IBA:GO_Central. # GO_process GO:0006396 RNA processing; IBA:GO_Central. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0004386 helicase activity # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.50.300 -; 2. # IntAct P37024 10 # InterPro IPR001650 Helicase_C # InterPro IPR007502 Helicase-assoc_dom # InterPro IPR010225 RNA_helicase_ATP-dep_DEAH_HrpB # InterPro IPR011545 DEAD/DEAH_box_helicase_dom # InterPro IPR013689 RNA_helicase_ATP-dep_HrpB_C # InterPro IPR014001 Helicase_ATP-bd # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko01000 Enzymes # Organism HRPB_ECOLI Escherichia coli (strain K12) # PATRIC 32115403 VBIEscCol129921_0153 # PIR D64738 D64738 # PIRSF PIRSF005496 ATP_hel_hrpB # PROSITE PS51192 HELICASE_ATP_BIND_1 # PROSITE PS51194 HELICASE_CTER # Pfam PF00270 DEAD # Pfam PF00271 Helicase_C # Pfam PF04408 HA2 # Pfam PF08482 HrpB_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HRPB_ECOLI ATP-dependent RNA helicase HrpB # RefSeq NP_414690 NC_000913.3 # SIMILARITY Belongs to the DEAD box helicase family. {ECO 0000305}. # SIMILARITY Contains 1 helicase ATP-binding domain. {ECO:0000255|PROSITE-ProRule PRU00541}. # SIMILARITY Contains 1 helicase C-terminal domain. {ECO:0000255|PROSITE-ProRule PRU00542}. # SMART SM00487 DEXDc # SMART SM00490 HELICc # SMART SM00847 HA2 # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR01970 DEAH_box_HrpB # eggNOG COG1643 LUCA # eggNOG ENOG4105CQ7 Bacteria BLAST swissprot:HRPB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HRPB_ECOLI BioCyc ECOL316407:JW0144-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0144-MONOMER BioCyc EcoCyc:EG12329-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12329-MONOMER COG COG1643 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1643 DIP DIP-9938N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9938N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1093/nar/23.4.595 http://dx.doi.org/10.1093/nar/23.4.595 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.4.13 http://www.genome.jp/dbget-bin/www_bget?EC:3.6.4.13 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D42122 http://www.ebi.ac.uk/ena/data/view/D42122 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.6.4.13 http://enzyme.expasy.org/EC/3.6.4.13 EchoBASE EB2233 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2233 EcoGene EG12329 http://www.ecogene.org/geneInfo.php?eg_id=EG12329 EnsemblBacteria AAC73259 http://www.ensemblgenomes.org/id/AAC73259 EnsemblBacteria AAC73259 http://www.ensemblgenomes.org/id/AAC73259 EnsemblBacteria BAE76044 http://www.ensemblgenomes.org/id/BAE76044 EnsemblBacteria BAE76044 http://www.ensemblgenomes.org/id/BAE76044 EnsemblBacteria BAE76044 http://www.ensemblgenomes.org/id/BAE76044 EnsemblBacteria b0148 http://www.ensemblgenomes.org/id/b0148 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004004 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004004 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0044822 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044822 GO_process GO:0006396 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006396 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0004386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004386 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 944845 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944845 HOGENOM HOG000244609 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000244609&db=HOGENOM6 InParanoid P37024 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37024 IntAct P37024 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37024* IntEnz 3.6.4.13 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.4.13 InterPro IPR001650 http://www.ebi.ac.uk/interpro/entry/IPR001650 InterPro IPR007502 http://www.ebi.ac.uk/interpro/entry/IPR007502 InterPro IPR010225 http://www.ebi.ac.uk/interpro/entry/IPR010225 InterPro IPR011545 http://www.ebi.ac.uk/interpro/entry/IPR011545 InterPro IPR013689 http://www.ebi.ac.uk/interpro/entry/IPR013689 InterPro IPR014001 http://www.ebi.ac.uk/interpro/entry/IPR014001 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0144 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0144 KEGG_Gene eco:b0148 http://www.genome.jp/dbget-bin/www_bget?eco:b0148 KEGG_Orthology KO:K03579 http://www.genome.jp/dbget-bin/www_bget?KO:K03579 MINT MINT-1231977 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1231977 OMA DLRILVM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DLRILVM PROSITE PS51192 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51192 PROSITE PS51194 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51194 PSORT swissprot:HRPB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HRPB_ECOLI PSORT-B swissprot:HRPB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HRPB_ECOLI PSORT2 swissprot:HRPB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HRPB_ECOLI Pfam PF00270 http://pfam.xfam.org/family/PF00270 Pfam PF00271 http://pfam.xfam.org/family/PF00271 Pfam PF04408 http://pfam.xfam.org/family/PF04408 Pfam PF08482 http://pfam.xfam.org/family/PF08482 Phobius swissprot:HRPB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HRPB_ECOLI PhylomeDB P37024 http://phylomedb.org/?seqid=P37024 ProteinModelPortal P37024 http://www.proteinmodelportal.org/query/uniprot/P37024 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7899078 http://www.ncbi.nlm.nih.gov/pubmed/7899078 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414690 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414690 SMART SM00487 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00487 SMART SM00490 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00490 SMART SM00847 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00847 SMR P37024 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37024 STRING 511145.b0148 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0148&targetmode=cogs STRING COG1643 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1643&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR01970 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01970 UniProtKB HRPB_ECOLI http://www.uniprot.org/uniprot/HRPB_ECOLI UniProtKB-AC P37024 http://www.uniprot.org/uniprot/P37024 charge swissprot:HRPB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HRPB_ECOLI eggNOG COG1643 http://eggnogapi.embl.de/nog_data/html/tree/COG1643 eggNOG ENOG4105CQ7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CQ7 epestfind swissprot:HRPB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HRPB_ECOLI garnier swissprot:HRPB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HRPB_ECOLI helixturnhelix swissprot:HRPB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HRPB_ECOLI hmoment swissprot:HRPB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HRPB_ECOLI iep swissprot:HRPB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HRPB_ECOLI inforesidue swissprot:HRPB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HRPB_ECOLI octanol swissprot:HRPB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HRPB_ECOLI pepcoil swissprot:HRPB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HRPB_ECOLI pepdigest swissprot:HRPB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HRPB_ECOLI pepinfo swissprot:HRPB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HRPB_ECOLI pepnet swissprot:HRPB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HRPB_ECOLI pepstats swissprot:HRPB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HRPB_ECOLI pepwheel swissprot:HRPB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HRPB_ECOLI pepwindow swissprot:HRPB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HRPB_ECOLI sigcleave swissprot:HRPB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HRPB_ECOLI ## Database ID URL or Descriptions # EcoGene EG40003 insC2 # FUNCTION INSC2_ECOLI Involved in the transposition of the insertion sequence IS2. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 1.10.10.60 -; 1. # InterPro IPR002514 Transposase_8 # InterPro IPR009057 Homeodomain-like # Organism INSC2_ECOLI Escherichia coli (strain K12) # PIR B65240 B65240 # Pfam PF01527 HTH_Tnp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSC2_ECOLI Transposase InsC for insertion element IS2D # RefSeq NP_414894 NC_000913.3 # RefSeq NP_415921 NC_000913.3 # RefSeq NP_417338 NC_000913.3 # RefSeq NP_417516 NC_000913.3 # RefSeq NP_418692 NC_000913.3 # RefSeq WP_000567766 NZ_LN832404.1 # RefSeq YP_026163 NC_000913.3 # SEQUENCE CAUTION Sequence=BAA15013.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the transposase 8 family. {ECO 0000305}. # SUPFAM SSF46689 SSF46689 # eggNOG COG2963 LUCA # eggNOG ENOG4108ZQS Bacteria BLAST swissprot:INSC2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSC2_ECOLI BioCyc EcoCyc:MONOMER0-4250 http://biocyc.org/getid?id=EcoCyc:MONOMER0-4250 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4725 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4725 EcoGene EG40003 http://www.ecogene.org/geneInfo.php?eg_id=EG40003 EnsemblBacteria AAC74485 http://www.ensemblgenomes.org/id/AAC74485 EnsemblBacteria AAC74485 http://www.ensemblgenomes.org/id/AAC74485 EnsemblBacteria BAA15013 http://www.ensemblgenomes.org/id/BAA15013 EnsemblBacteria BAA15013 http://www.ensemblgenomes.org/id/BAA15013 EnsemblBacteria BAA15013 http://www.ensemblgenomes.org/id/BAA15013 EnsemblBacteria b1403 http://www.ensemblgenomes.org/id/b1403 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 GeneID 945025 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945025 GeneID 945967 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945967 GeneID 946455 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946455 GeneID 947347 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947347 GeneID 947520 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947520 GeneID 948781 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948781 InParanoid P0CF41 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CF41 InterPro IPR002514 http://www.ebi.ac.uk/interpro/entry/IPR002514 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 KEGG_Gene ecj:JW1400 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1400 KEGG_Gene eco:b0360 http://www.genome.jp/dbget-bin/www_bget?eco:b0360 KEGG_Gene eco:b1403 http://www.genome.jp/dbget-bin/www_bget?eco:b1403 KEGG_Gene eco:b1997 http://www.genome.jp/dbget-bin/www_bget?eco:b1997 KEGG_Gene eco:b2861 http://www.genome.jp/dbget-bin/www_bget?eco:b2861 KEGG_Gene eco:b3044 http://www.genome.jp/dbget-bin/www_bget?eco:b3044 KEGG_Gene eco:b4272 http://www.genome.jp/dbget-bin/www_bget?eco:b4272 PSORT swissprot:INSC2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSC2_ECOLI PSORT-B swissprot:INSC2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSC2_ECOLI PSORT2 swissprot:INSC2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSC2_ECOLI Pfam PF01527 http://pfam.xfam.org/family/PF01527 Phobius swissprot:INSC2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSC2_ECOLI PhylomeDB P0CF41 http://phylomedb.org/?seqid=P0CF41 ProteinModelPortal P0CF41 http://www.proteinmodelportal.org/query/uniprot/P0CF41 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414894 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414894 RefSeq NP_415921 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415921 RefSeq NP_417338 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417338 RefSeq NP_417516 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417516 RefSeq NP_418692 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418692 RefSeq WP_000567766 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000567766 RefSeq YP_026163 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026163 STRING 511145.b4272 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4272&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 UniProtKB INSC2_ECOLI http://www.uniprot.org/uniprot/INSC2_ECOLI UniProtKB-AC P0CF41 http://www.uniprot.org/uniprot/P0CF41 charge swissprot:INSC2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSC2_ECOLI eggNOG COG2963 http://eggnogapi.embl.de/nog_data/html/tree/COG2963 eggNOG ENOG4108ZQS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZQS epestfind swissprot:INSC2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSC2_ECOLI garnier swissprot:INSC2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSC2_ECOLI helixturnhelix swissprot:INSC2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSC2_ECOLI hmoment swissprot:INSC2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSC2_ECOLI iep swissprot:INSC2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSC2_ECOLI inforesidue swissprot:INSC2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSC2_ECOLI octanol swissprot:INSC2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSC2_ECOLI pepcoil swissprot:INSC2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSC2_ECOLI pepdigest swissprot:INSC2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSC2_ECOLI pepinfo swissprot:INSC2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSC2_ECOLI pepnet swissprot:INSC2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSC2_ECOLI pepstats swissprot:INSC2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSC2_ECOLI pepwheel swissprot:INSC2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSC2_ECOLI pepwindow swissprot:INSC2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSC2_ECOLI sigcleave swissprot:INSC2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSC2_ECOLI ## Database ID URL or Descriptions # BioGrid 4262844 10 # EcoGene EG11820 yceI # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GOslim_component GO:0005575 cellular_component # Gene3D 2.40.128.110 -; 1. # HAMAP MF_00780 UPF0312 # IntAct P0A8X2 4 # InterPro IPR007372 Lipid/polyisoprenoid-bd_YceI # InterPro IPR023480 UPF0312/YceI # Organism YCEI_ECOLI Escherichia coli (strain K12) # PATRIC 32117349 VBIEscCol129921_1097 # PDB 1Y0G X-ray; 2.20 A; A/B/C/D=1-191 # PIR E64848 E64848 # Pfam PF04264 YceI # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCEI_ECOLI Protein YceI # RefSeq NP_415574 NC_000913.3 # RefSeq WP_000749261 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0312 family. Type 1 subfamily. {ECO 0000305}. # SMART SM00867 YceI # SUBCELLULAR LOCATION YCEI_ECOLI Periplasm {ECO 0000305}. # SUPFAM SSF101874 SSF101874 # eggNOG COG2353 LUCA # eggNOG ENOG4108YYC Bacteria BLAST swissprot:YCEI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCEI_ECOLI BioCyc ECOL316407:JW1043-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1043-MONOMER BioCyc EcoCyc:EG11820-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11820-MONOMER DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1991.tb02159.x http://dx.doi.org/10.1111/j.1365-2958.1991.tb02159.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X61000 http://www.ebi.ac.uk/ena/data/view/X61000 EchoBASE EB1767 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1767 EcoGene EG11820 http://www.ecogene.org/geneInfo.php?eg_id=EG11820 EnsemblBacteria AAC74140 http://www.ensemblgenomes.org/id/AAC74140 EnsemblBacteria AAC74140 http://www.ensemblgenomes.org/id/AAC74140 EnsemblBacteria BAA35854 http://www.ensemblgenomes.org/id/BAA35854 EnsemblBacteria BAA35854 http://www.ensemblgenomes.org/id/BAA35854 EnsemblBacteria BAA35854 http://www.ensemblgenomes.org/id/BAA35854 EnsemblBacteria b1056 http://www.ensemblgenomes.org/id/b1056 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 Gene3D 2.40.128.110 http://www.cathdb.info/version/latest/superfamily/2.40.128.110 GeneID 946145 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946145 HAMAP MF_00780 http://hamap.expasy.org/unirule/MF_00780 HOGENOM HOG000262659 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000262659&db=HOGENOM6 InParanoid P0A8X2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8X2 IntAct P0A8X2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8X2* InterPro IPR007372 http://www.ebi.ac.uk/interpro/entry/IPR007372 InterPro IPR023480 http://www.ebi.ac.uk/interpro/entry/IPR023480 KEGG_Gene ecj:JW1043 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1043 KEGG_Gene eco:b1056 http://www.genome.jp/dbget-bin/www_bget?eco:b1056 OMA GNYRAGF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GNYRAGF PDB 1Y0G http://www.ebi.ac.uk/pdbe-srv/view/entry/1Y0G PDBsum 1Y0G http://www.ebi.ac.uk/pdbsum/1Y0G PSORT swissprot:YCEI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCEI_ECOLI PSORT-B swissprot:YCEI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCEI_ECOLI PSORT2 swissprot:YCEI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCEI_ECOLI Pfam PF04264 http://pfam.xfam.org/family/PF04264 Phobius swissprot:YCEI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCEI_ECOLI PhylomeDB P0A8X2 http://phylomedb.org/?seqid=P0A8X2 ProteinModelPortal P0A8X2 http://www.proteinmodelportal.org/query/uniprot/P0A8X2 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1840644 http://www.ncbi.nlm.nih.gov/pubmed/1840644 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_415574 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415574 RefSeq WP_000749261 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000749261 SMART SM00867 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00867 SMR P0A8X2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8X2 STRING 511145.b1056 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1056&targetmode=cogs SUPFAM SSF101874 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF101874 SWISS-2DPAGE P0A8X2 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A8X2 UniProtKB YCEI_ECOLI http://www.uniprot.org/uniprot/YCEI_ECOLI UniProtKB-AC P0A8X2 http://www.uniprot.org/uniprot/P0A8X2 charge swissprot:YCEI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCEI_ECOLI eggNOG COG2353 http://eggnogapi.embl.de/nog_data/html/tree/COG2353 eggNOG ENOG4108YYC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108YYC epestfind swissprot:YCEI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCEI_ECOLI garnier swissprot:YCEI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCEI_ECOLI helixturnhelix swissprot:YCEI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCEI_ECOLI hmoment swissprot:YCEI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCEI_ECOLI iep swissprot:YCEI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCEI_ECOLI inforesidue swissprot:YCEI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCEI_ECOLI octanol swissprot:YCEI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCEI_ECOLI pepcoil swissprot:YCEI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCEI_ECOLI pepdigest swissprot:YCEI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCEI_ECOLI pepinfo swissprot:YCEI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCEI_ECOLI pepnet swissprot:YCEI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCEI_ECOLI pepstats swissprot:YCEI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCEI_ECOLI pepwheel swissprot:YCEI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCEI_ECOLI pepwindow swissprot:YCEI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCEI_ECOLI sigcleave swissprot:YCEI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCEI_ECOLI ## Database ID URL or Descriptions # AltName Dephospho-CoA pyrophosphorylase {ECO:0000255|HAMAP-Rule MF_00151} # AltName Pantetheine-phosphate adenylyltransferase {ECO:0000255|HAMAP-Rule MF_00151} # BIOPHYSICOCHEMICAL PROPERTIES COAD_ECOLI Kinetic parameters KM=7.0 uM for 3'-dephospho-CoA {ECO 0000269|PubMed 10480925}; KM=17.0 uM for 3'-dephospho-CoA {ECO 0000269|PubMed 17873050}; KM=0.22 mM for diphosphate {ECO 0000269|PubMed 10480925}; KM=0.23 mM for diphosphate {ECO 0000269|PubMed 17873050}; KM=220 uM for ATP {ECO 0000269|PubMed 17873050}; KM=4.7 uM for 4'-phosphopantetheine {ECO 0000269|PubMed 17873050}; Note=kcat is 1.37/s (PubMed 17873050) to 3.3/s (PubMed 10480925). {ECO 0000269|PubMed 10480925, ECO 0000269|PubMed 17873050}; pH dependence Optimum pH is 6.9. {ECO 0000269|PubMed 10480925}; # BRENDA 2.7.7 2026 # BioGrid 4263379 238 # CATALYTIC ACTIVITY COAD_ECOLI ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA. {ECO 0000255|HAMAP-Rule MF_00151, ECO 0000269|PubMed 10480925, ECO 0000269|PubMed 17873050}. # CAUTION Was originally thought to have an essential function in lipopolysaccharide biosynthesis. {ECO:0000305|PubMed 1577693}. # CDD cd02163 PPAT # COFACTOR COAD_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 11812124}; Note=Crystallized in the absence of Mg(2+), the catalytic metal is not bound by the protein but probably by non-esterified oxygen atoms from ATP and/or ordered H(2)O (PubMed 11812124). {ECO 0000305|PubMed 11812124}; # ENZYME REGULATION COAD_ECOLI Inhibited by CoA, which competes with ATP, 4'- phosphopantetheine and 3'-dephospho-CoA (PubMed 12837781). Binds 0.5 CoA tightly per monomer in the same position as 3'-dephospho- CoA but in a different fashion (PubMed 12837781, PubMed 17873050). CoA is not a substrate for the enzyme (PubMed 10480925). {ECO 0000269|PubMed 12837781, ECO 0000269|PubMed 17873050, ECO 0000305|PubMed 10480925}. # EcoGene EG11190 coaD # FUNCTION COAD_ECOLI Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (PubMed 10480925). The crystal structures in complex with substrates suggest the enyzme stabilizes the transition state without the direct involvement of enzymatic functional groups in the reaction (PubMed 11812124). {ECO 0000269|PubMed 10480925, ECO 0000269|PubMed 11812124}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0004595 pantetheine-phosphate adenylyltransferase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0015937 coenzyme A biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.620 -; 1. # HAMAP MF_00151 PPAT_bact # IntAct P0A6I6 10 # InterPro IPR001980 LPS_biosynth # InterPro IPR004821 Cyt_trans-like # InterPro IPR014729 Rossmann-like_a/b/a_fold # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00770 Pantothenate and CoA biosynthesis # Organism COAD_ECOLI Escherichia coli (strain K12) # PATHWAY Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5. {ECO 0000255|HAMAP-Rule:MF_00151}. # PATRIC 32122755 VBIEscCol129921_3754 # PDB 1B6T X-ray; 1.80 A; A/B=1-159 # PDB 1GN8 X-ray; 1.83 A; A/B=1-159 # PDB 1H1T X-ray; 1.78 A; A/B=1-159 # PDB 1QJC X-ray; 1.63 A; A/B=2-159 # PDB 5JBN X-ray; 1.45 A; A/B=1-159 # PIR JU0468 JU0468 # PRINTS PR01020 LPSBIOSNTHSS # Pfam PF01467 CTP_transf_like # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Phosphopantetheine adenylyltransferase {ECO:0000255|HAMAP-Rule MF_00151} # RefSeq NP_418091 NC_000913.3 # RefSeq WP_001171866 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial CoaD family. {ECO:0000255|HAMAP-Rule MF_00151}. # SUBCELLULAR LOCATION COAD_ECOLI Cytoplasm. # SUBUNIT COAD_ECOLI Homohexamer, a dimerized trimer with a solvent channel through the middle (PubMed 10480925, PubMed 10205156, PubMed 11812124, PubMed 12837781, PubMed 17873050). In crystals only 1 trimer is seen to bind substrate/product at a time (PubMed 10205156, PubMed 11812124). {ECO 0000269|PubMed 10205156, ECO 0000269|PubMed 10480925, ECO 0000269|PubMed 11812124, ECO 0000269|PubMed 12837781, ECO 0000269|PubMed 17873050}. # TIGRFAMs TIGR00125 cyt_tran_rel # TIGRFAMs TIGR01510 coaD_prev_kdtB # UniPathway UPA00241 UER00355 # eggNOG COG0669 LUCA # eggNOG ENOG4108ZEF Bacteria BLAST swissprot:COAD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:COAD_ECOLI BioCyc ECOL316407:JW3609-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3609-MONOMER BioCyc EcoCyc:PANTEPADENYLYLTRAN-MONOMER http://biocyc.org/getid?id=EcoCyc:PANTEPADENYLYLTRAN-MONOMER BioCyc MetaCyc:PANTEPADENYLYLTRAN-MONOMER http://biocyc.org/getid?id=MetaCyc:PANTEPADENYLYLTRAN-MONOMER COG COG0669 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0669 DIP DIP-35966N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35966N DOI 10.1006/jmbi.2001.5272 http://dx.doi.org/10.1006/jmbi.2001.5272 DOI 10.1007/s10858-016-0032-2 http://dx.doi.org/10.1007/s10858-016-0032-2 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.274.38.27105 http://dx.doi.org/10.1074/jbc.274.38.27105 DOI 10.1093/emboj/18.8.2021 http://dx.doi.org/10.1093/emboj/18.8.2021 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00732-07 http://dx.doi.org/10.1128/JB.00732-07 DOI 10.1128/JB.185.14.4074-4080.2003 http://dx.doi.org/10.1128/JB.185.14.4074-4080.2003 EC_number EC:2.7.7.3 {ECO:0000255|HAMAP-Rule:MF_00151, ECO:0000269|PubMed:10480925, ECO:0000269|PubMed:17873050} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.3 {ECO:0000255|HAMAP-Rule:MF_00151, ECO:0000269|PubMed:10480925, ECO:0000269|PubMed:17873050} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M60670 http://www.ebi.ac.uk/ena/data/view/M60670 EMBL M86305 http://www.ebi.ac.uk/ena/data/view/M86305 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.7.3 {ECO:0000255|HAMAP-Rule:MF_00151, ECO:0000269|PubMed:10480925, ECO:0000269|PubMed:17873050} http://enzyme.expasy.org/EC/2.7.7.3 {ECO:0000255|HAMAP-Rule:MF_00151, ECO:0000269|PubMed:10480925, ECO:0000269|PubMed:17873050} EchoBASE EB1176 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1176 EcoGene EG11190 http://www.ecogene.org/geneInfo.php?eg_id=EG11190 EnsemblBacteria AAC76658 http://www.ensemblgenomes.org/id/AAC76658 EnsemblBacteria AAC76658 http://www.ensemblgenomes.org/id/AAC76658 EnsemblBacteria BAE77658 http://www.ensemblgenomes.org/id/BAE77658 EnsemblBacteria BAE77658 http://www.ensemblgenomes.org/id/BAE77658 EnsemblBacteria BAE77658 http://www.ensemblgenomes.org/id/BAE77658 EnsemblBacteria b3634 http://www.ensemblgenomes.org/id/b3634 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004595 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004595 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0015937 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015937 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 GeneID 947386 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947386 HAMAP MF_00151 http://hamap.expasy.org/unirule/MF_00151 HOGENOM HOG000006518 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006518&db=HOGENOM6 InParanoid P0A6I6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6I6 IntAct P0A6I6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6I6* IntEnz 2.7.7.3 {ECO:0000255|HAMAP-Rule:MF_00151, ECO:0000269|PubMed:10480925, ECO:0000269|PubMed:17873050} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.3 {ECO:0000255|HAMAP-Rule:MF_00151, ECO:0000269|PubMed:10480925, ECO:0000269|PubMed:17873050} InterPro IPR001980 http://www.ebi.ac.uk/interpro/entry/IPR001980 InterPro IPR004821 http://www.ebi.ac.uk/interpro/entry/IPR004821 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3609 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3609 KEGG_Gene eco:b3634 http://www.genome.jp/dbget-bin/www_bget?eco:b3634 KEGG_Orthology KO:K00954 http://www.genome.jp/dbget-bin/www_bget?KO:K00954 KEGG_Pathway ko00770 http://www.genome.jp/kegg-bin/show_pathway?ko00770 KEGG_Reaction rn:R03035 http://www.genome.jp/dbget-bin/www_bget?rn:R03035 OMA EFQMALM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EFQMALM PDB 1B6T http://www.ebi.ac.uk/pdbe-srv/view/entry/1B6T PDB 1GN8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1GN8 PDB 1H1T http://www.ebi.ac.uk/pdbe-srv/view/entry/1H1T PDB 1QJC http://www.ebi.ac.uk/pdbe-srv/view/entry/1QJC PDB 5JBN http://www.ebi.ac.uk/pdbe-srv/view/entry/5JBN PDBsum 1B6T http://www.ebi.ac.uk/pdbsum/1B6T PDBsum 1GN8 http://www.ebi.ac.uk/pdbsum/1GN8 PDBsum 1H1T http://www.ebi.ac.uk/pdbsum/1H1T PDBsum 1QJC http://www.ebi.ac.uk/pdbsum/1QJC PDBsum 5JBN http://www.ebi.ac.uk/pdbsum/5JBN PRINTS PR01020 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01020 PSORT swissprot:COAD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:COAD_ECOLI PSORT-B swissprot:COAD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:COAD_ECOLI PSORT2 swissprot:COAD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:COAD_ECOLI Pfam PF01467 http://pfam.xfam.org/family/PF01467 Phobius swissprot:COAD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:COAD_ECOLI PhylomeDB P0A6I6 http://phylomedb.org/?seqid=P0A6I6 ProteinModelPortal P0A6I6 http://www.proteinmodelportal.org/query/uniprot/P0A6I6 PubMed 10205156 http://www.ncbi.nlm.nih.gov/pubmed/10205156 PubMed 10480925 http://www.ncbi.nlm.nih.gov/pubmed/10480925 PubMed 11812124 http://www.ncbi.nlm.nih.gov/pubmed/11812124 PubMed 12837781 http://www.ncbi.nlm.nih.gov/pubmed/12837781 PubMed 1577693 http://www.ncbi.nlm.nih.gov/pubmed/1577693 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17873050 http://www.ncbi.nlm.nih.gov/pubmed/17873050 PubMed 2033061 http://www.ncbi.nlm.nih.gov/pubmed/2033061 PubMed 27130242 http://www.ncbi.nlm.nih.gov/pubmed/27130242 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418091 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418091 RefSeq WP_001171866 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001171866 SMR P0A6I6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6I6 STRING 511145.b3634 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3634&targetmode=cogs STRING COG0669 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0669&targetmode=cogs TIGRFAMs TIGR00125 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00125 TIGRFAMs TIGR01510 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01510 UniProtKB COAD_ECOLI http://www.uniprot.org/uniprot/COAD_ECOLI UniProtKB-AC P0A6I6 http://www.uniprot.org/uniprot/P0A6I6 charge swissprot:COAD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:COAD_ECOLI eggNOG COG0669 http://eggnogapi.embl.de/nog_data/html/tree/COG0669 eggNOG ENOG4108ZEF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZEF epestfind swissprot:COAD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:COAD_ECOLI garnier swissprot:COAD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:COAD_ECOLI helixturnhelix swissprot:COAD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:COAD_ECOLI hmoment swissprot:COAD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:COAD_ECOLI iep swissprot:COAD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:COAD_ECOLI inforesidue swissprot:COAD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:COAD_ECOLI octanol swissprot:COAD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:COAD_ECOLI pepcoil swissprot:COAD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:COAD_ECOLI pepdigest swissprot:COAD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:COAD_ECOLI pepinfo swissprot:COAD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:COAD_ECOLI pepnet swissprot:COAD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:COAD_ECOLI pepstats swissprot:COAD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:COAD_ECOLI pepwheel swissprot:COAD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:COAD_ECOLI pepwindow swissprot:COAD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:COAD_ECOLI sigcleave swissprot:COAD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:COAD_ECOLI ## Database ID URL or Descriptions # AltName TESB_ECOLI Acyl-CoA thioesterase II # BRENDA 3.1.2 2026 # BRENDA 3.1.2.20 2026 # BioGrid 4259857 16 # EcoGene EG10995 tesB # FUNCTION TESB_ECOLI Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0047617 acyl-CoA hydrolase activity; IDA:EcoCyc. # GO_process GO:0006637 acyl-CoA metabolic process; IEA:InterPro. # GO_process GO:0009062 fatty acid catabolic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.10.129.10 -; 2. # IntAct P0AGG2 5 # InterPro IPR003703 Acyl_CoA_thio # InterPro IPR029069 HotDog_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01004 Lipid biosynthesis proteins # KEGG_Pathway ko01040 Biosynthesis of unsaturated fatty acids # Organism TESB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11066 PTHR11066 # PATRIC 32116059 VBIEscCol129921_0471 # PDB 1C8U X-ray; 1.90 A; A/B=2-286 # PIR D64775 D64775 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TESB_ECOLI Acyl-CoA thioesterase 2 # RefSeq NP_414986 NC_000913.3 # RefSeq WP_000075876 NZ_LN832404.1 # SIMILARITY Belongs to the C/M/P thioester hydrolase family. {ECO 0000305}. # SUBUNIT TESB_ECOLI Homotetramer. # SUPFAM SSF54637 SSF54637; 2 # TIGRFAMs TIGR00189 tesB # eggNOG COG1946 LUCA # eggNOG ENOG4105C29 Bacteria BLAST swissprot:TESB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TESB_ECOLI BioCyc ECOL316407:JW0442-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0442-MONOMER BioCyc EcoCyc:THIOESTERII-MONOMER http://biocyc.org/getid?id=EcoCyc:THIOESTERII-MONOMER BioCyc MetaCyc:THIOESTERII-MONOMER http://biocyc.org/getid?id=MetaCyc:THIOESTERII-MONOMER COG COG1946 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1946 DIP DIP-10980N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10980N DOI 10.1038/76776 http://dx.doi.org/10.1038/76776 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.2.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.2.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M63308 http://www.ebi.ac.uk/ena/data/view/M63308 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 ENZYME 3.1.2.- http://enzyme.expasy.org/EC/3.1.2.- EchoBASE EB0988 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0988 EcoGene EG10995 http://www.ecogene.org/geneInfo.php?eg_id=EG10995 EnsemblBacteria AAC73555 http://www.ensemblgenomes.org/id/AAC73555 EnsemblBacteria AAC73555 http://www.ensemblgenomes.org/id/AAC73555 EnsemblBacteria BAE76232 http://www.ensemblgenomes.org/id/BAE76232 EnsemblBacteria BAE76232 http://www.ensemblgenomes.org/id/BAE76232 EnsemblBacteria BAE76232 http://www.ensemblgenomes.org/id/BAE76232 EnsemblBacteria b0452 http://www.ensemblgenomes.org/id/b0452 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0047617 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047617 GO_process GO:0006637 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006637 GO_process GO:0009062 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009062 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.10.129.10 http://www.cathdb.info/version/latest/superfamily/3.10.129.10 GeneID 945074 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945074 HOGENOM HOG000246495 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000246495&db=HOGENOM6 InParanoid P0AGG2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGG2 IntAct P0AGG2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AGG2* IntEnz 3.1.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.2 InterPro IPR003703 http://www.ebi.ac.uk/interpro/entry/IPR003703 InterPro IPR029069 http://www.ebi.ac.uk/interpro/entry/IPR029069 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01004 http://www.genome.jp/dbget-bin/www_bget?ko01004 KEGG_Gene ecj:JW0442 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0442 KEGG_Gene eco:b0452 http://www.genome.jp/dbget-bin/www_bget?eco:b0452 KEGG_Orthology KO:K10805 http://www.genome.jp/dbget-bin/www_bget?KO:K10805 KEGG_Pathway ko01040 http://www.genome.jp/kegg-bin/show_pathway?ko01040 OMA IYDVEIL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IYDVEIL PANTHER PTHR11066 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11066 PDB 1C8U http://www.ebi.ac.uk/pdbe-srv/view/entry/1C8U PDBsum 1C8U http://www.ebi.ac.uk/pdbsum/1C8U PSORT swissprot:TESB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TESB_ECOLI PSORT-B swissprot:TESB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TESB_ECOLI PSORT2 swissprot:TESB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TESB_ECOLI Phobius swissprot:TESB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TESB_ECOLI PhylomeDB P0AGG2 http://phylomedb.org/?seqid=P0AGG2 ProteinModelPortal P0AGG2 http://www.proteinmodelportal.org/query/uniprot/P0AGG2 PubMed 10876240 http://www.ncbi.nlm.nih.gov/pubmed/10876240 PubMed 1645722 http://www.ncbi.nlm.nih.gov/pubmed/1645722 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414986 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414986 RefSeq WP_000075876 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000075876 SMR P0AGG2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AGG2 STRING 511145.b0452 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0452&targetmode=cogs STRING COG1946 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1946&targetmode=cogs SUPFAM SSF54637 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54637 TIGRFAMs TIGR00189 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00189 UniProtKB TESB_ECOLI http://www.uniprot.org/uniprot/TESB_ECOLI UniProtKB-AC P0AGG2 http://www.uniprot.org/uniprot/P0AGG2 charge swissprot:TESB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TESB_ECOLI eggNOG COG1946 http://eggnogapi.embl.de/nog_data/html/tree/COG1946 eggNOG ENOG4105C29 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C29 epestfind swissprot:TESB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TESB_ECOLI garnier swissprot:TESB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TESB_ECOLI helixturnhelix swissprot:TESB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TESB_ECOLI hmoment swissprot:TESB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TESB_ECOLI iep swissprot:TESB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TESB_ECOLI inforesidue swissprot:TESB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TESB_ECOLI octanol swissprot:TESB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TESB_ECOLI pepcoil swissprot:TESB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TESB_ECOLI pepdigest swissprot:TESB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TESB_ECOLI pepinfo swissprot:TESB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TESB_ECOLI pepnet swissprot:TESB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TESB_ECOLI pepstats swissprot:TESB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TESB_ECOLI pepwheel swissprot:TESB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TESB_ECOLI pepwindow swissprot:TESB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TESB_ECOLI sigcleave swissprot:TESB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TESB_ECOLI ## Database ID URL or Descriptions # AltName DBHB_ECOLI HU-1 # AltName DBHB_ECOLI NS1 # BioGrid 4260733 44 # EcoGene EG10467 hupB # FUNCTION DBHB_ECOLI Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0030261 chromosome condensation; IEA:UniProtKB-KW. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0051276 chromosome organization # Gene3D 4.10.520.10 -; 1. # INTERACTION DBHB_ECOLI Self; NbExp=2; IntAct=EBI-370411, EBI-370411; P0ACF0 hupA; NbExp=6; IntAct=EBI-370411, EBI-547648; # IntAct P0ACF4 68 # InterPro IPR000119 Hist_DNA-bd # InterPro IPR010992 IHF-like_DNA-bd_dom # InterPro IPR020816 Histone-like_DNA-bd_CS # KEGG_Brite ko03032 DNA replication proteins # KEGG_Brite ko03036 Chromosome # KEGG_Brite ko03400 DNA repair and recombination proteins # Organism DBHB_ECOLI Escherichia coli (strain K12) # PATRIC 32116033 VBIEscCol129921_0458 # PDB 2O97 X-ray; 2.45 A; B=1-90 # PDB 4P3V X-ray; 1.25 A; A=1-90 # PIR S06880 DNECS1 # PRINTS PR01727 DNABINDINGHU # PROSITE PS00045 HISTONE_LIKE # Pfam PF00216 Bac_DNA_binding # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DBHB_ECOLI DNA-binding protein HU-beta # RefSeq NP_414974 NC_000913.3 # RefSeq WP_001043542 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial histone-like protein family. {ECO 0000305}. # SMART SM00411 BHL # SUBUNIT Heterodimer of an alpha and a beta chain. {ECO:0000269|PubMed 227733}. # SUPFAM SSF47729 SSF47729 # eggNOG COG0776 LUCA # eggNOG ENOG4105K70 Bacteria BLAST swissprot:DBHB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DBHB_ECOLI BioCyc ECOL316407:JW0430-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0430-MONOMER BioCyc EcoCyc:EG10467-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10467-MONOMER COG COG0776 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0776 DIP DIP-31833N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31833N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1007/BF00425687 http://dx.doi.org/10.1007/BF00425687 DOI 10.1016/0014-5793(78)80446-3 http://dx.doi.org/10.1016/0014-5793(78)80446-3 DOI 10.1016/0014-5793(78)80535-3 http://dx.doi.org/10.1016/0014-5793(78)80535-3 DOI 10.1016/0014-5793(79)80518-9 http://dx.doi.org/10.1016/0014-5793(79)80518-9 DOI 10.1016/0378-1119(90)90355-U http://dx.doi.org/10.1016/0378-1119(90)90355-U DOI 10.1016/S0022-2836(05)80119-6 http://dx.doi.org/10.1016/S0022-2836(05)80119-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1432-1033.1980.tb05968.x http://dx.doi.org/10.1111/j.1432-1033.1980.tb05968.x DOI 10.1111/j.1574-6968.1998.tb13343.x http://dx.doi.org/10.1111/j.1574-6968.1998.tb13343.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D82943 http://www.ebi.ac.uk/ena/data/view/D82943 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL X16540 http://www.ebi.ac.uk/ena/data/view/X16540 EMBL X53241 http://www.ebi.ac.uk/ena/data/view/X53241 EchoBASE EB0462 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0462 EcoGene EG10467 http://www.ecogene.org/geneInfo.php?eg_id=EG10467 EnsemblBacteria AAC73543 http://www.ensemblgenomes.org/id/AAC73543 EnsemblBacteria AAC73543 http://www.ensemblgenomes.org/id/AAC73543 EnsemblBacteria BAE76220 http://www.ensemblgenomes.org/id/BAE76220 EnsemblBacteria BAE76220 http://www.ensemblgenomes.org/id/BAE76220 EnsemblBacteria BAE76220 http://www.ensemblgenomes.org/id/BAE76220 EnsemblBacteria b0440 http://www.ensemblgenomes.org/id/b0440 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0030261 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030261 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0051276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051276 Gene3D 4.10.520.10 http://www.cathdb.info/version/latest/superfamily/4.10.520.10 GeneID 949095 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949095 HOGENOM HOG000043828 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000043828&db=HOGENOM6 InParanoid P0ACF4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACF4 IntAct P0ACF4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACF4* InterPro IPR000119 http://www.ebi.ac.uk/interpro/entry/IPR000119 InterPro IPR010992 http://www.ebi.ac.uk/interpro/entry/IPR010992 InterPro IPR020816 http://www.ebi.ac.uk/interpro/entry/IPR020816 KEGG_Brite ko03032 http://www.genome.jp/dbget-bin/www_bget?ko03032 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW0430 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0430 KEGG_Gene eco:b0440 http://www.genome.jp/dbget-bin/www_bget?eco:b0440 KEGG_Orthology KO:K03530 http://www.genome.jp/dbget-bin/www_bget?KO:K03530 MINT MINT-1236756 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1236756 OMA GSWSVSK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GSWSVSK PDB 2O97 http://www.ebi.ac.uk/pdbe-srv/view/entry/2O97 PDB 4P3V http://www.ebi.ac.uk/pdbe-srv/view/entry/4P3V PDBsum 2O97 http://www.ebi.ac.uk/pdbsum/2O97 PDBsum 4P3V http://www.ebi.ac.uk/pdbsum/4P3V PRINTS PR01727 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01727 PROSITE PS00045 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00045 PSORT swissprot:DBHB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DBHB_ECOLI PSORT-B swissprot:DBHB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DBHB_ECOLI PSORT2 swissprot:DBHB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DBHB_ECOLI Pfam PF00216 http://pfam.xfam.org/family/PF00216 Phobius swissprot:DBHB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DBHB_ECOLI PhylomeDB P0ACF4 http://phylomedb.org/?seqid=P0ACF4 ProteinModelPortal P0ACF4 http://www.proteinmodelportal.org/query/uniprot/P0ACF4 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 215461 http://www.ncbi.nlm.nih.gov/pubmed/215461 PubMed 2187099 http://www.ncbi.nlm.nih.gov/pubmed/2187099 PubMed 2265752 http://www.ncbi.nlm.nih.gov/pubmed/2265752 PubMed 227733 http://www.ncbi.nlm.nih.gov/pubmed/227733 PubMed 3003540 http://www.ncbi.nlm.nih.gov/pubmed/3003540 PubMed 350619 http://www.ncbi.nlm.nih.gov/pubmed/350619 PubMed 6987059 http://www.ncbi.nlm.nih.gov/pubmed/6987059 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9868784 http://www.ncbi.nlm.nih.gov/pubmed/9868784 RefSeq NP_414974 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414974 RefSeq WP_001043542 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001043542 SMART SM00411 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00411 SMR P0ACF4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACF4 STRING 511145.b0440 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0440&targetmode=cogs STRING COG0776 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0776&targetmode=cogs SUPFAM SSF47729 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47729 UniProtKB DBHB_ECOLI http://www.uniprot.org/uniprot/DBHB_ECOLI UniProtKB-AC P0ACF4 http://www.uniprot.org/uniprot/P0ACF4 charge swissprot:DBHB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DBHB_ECOLI eggNOG COG0776 http://eggnogapi.embl.de/nog_data/html/tree/COG0776 eggNOG ENOG4105K70 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K70 epestfind swissprot:DBHB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DBHB_ECOLI garnier swissprot:DBHB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DBHB_ECOLI helixturnhelix swissprot:DBHB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DBHB_ECOLI hmoment swissprot:DBHB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DBHB_ECOLI iep swissprot:DBHB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DBHB_ECOLI inforesidue swissprot:DBHB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DBHB_ECOLI octanol swissprot:DBHB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DBHB_ECOLI pepcoil swissprot:DBHB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DBHB_ECOLI pepdigest swissprot:DBHB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DBHB_ECOLI pepinfo swissprot:DBHB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DBHB_ECOLI pepnet swissprot:DBHB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DBHB_ECOLI pepstats swissprot:DBHB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DBHB_ECOLI pepwheel swissprot:DBHB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DBHB_ECOLI pepwindow swissprot:DBHB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DBHB_ECOLI sigcleave swissprot:DBHB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DBHB_ECOLI ## Database ID URL or Descriptions # BioGrid 4259924 3 # CDD cd00383 trans_reg_C # EcoGene EG10517 kdpE # FUNCTION KDPE_ECOLI Member of the two-component regulatory system KdpD/KdpE involved in the regulation of the kdp operon. {ECO 0000269|PubMed 1532388}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0000986 bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding; IDA:EcoCyc. # GO_function GO:0001131 transcription factor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding; IDA:EcoCyc. # GO_process GO:0000160 phosphorelay signal transduction system; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # INTERACTION KDPE_ECOLI P21865 kdpD; NbExp=5; IntAct=EBI-6403634, EBI-1123100; P52108 rstA; NbExp=2; IntAct=EBI-6403634, EBI-558990; # IntAct P21866 2 # InterPro IPR001789 Sig_transdc_resp-reg_receiver # InterPro IPR001867 OmpR/PhoB-type_DNA-bd # InterPro IPR011006 CheY-like_superfamily # InterPro IPR011991 WHTH_DNA-bd_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02022 M00454 KdpD-KdpE (potassium transport) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # Organism KDPE_ECOLI Escherichia coli (strain K12) # PATRIC 32116583 VBIEscCol129921_0724 # PDB 1ZH2 X-ray; 2.00 A; A/B=1-121 # PDB 1ZH4 X-ray; 2.20 A; A/B=1-121 # PDB 3ZQ7 X-ray; 2.52 A; A=124-225 # PDB 4KFC X-ray; 2.53 A; A/B=3-225 # PDB 4KNY X-ray; 2.94 A; A/B=3-225 # PDB 4L85 X-ray; 2.20 A; A/B/C=3-121 # PIR E64804 E64804 # PROSITE PS50110 RESPONSE_REGULATORY # PROSITE PS51755 OMPR_PHOB # PTM KDPE_ECOLI Phosphorylated by KdpD. {ECO 0000305}. # Pfam PF00072 Response_reg # Pfam PF00486 Trans_reg_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName KDPE_ECOLI KDP operon transcriptional regulatory protein KdpE # RefSeq NP_415222 NC_000913.3 # RefSeq WP_000186076 NZ_CP014272.1 # SIMILARITY Contains 1 OmpR/PhoB-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU01091}. # SIMILARITY Contains 1 response regulatory domain. {ECO:0000255|PROSITE-ProRule PRU00169}. # SMART SM00448 REC # SMART SM00862 Trans_reg_C # SUBCELLULAR LOCATION KDPE_ECOLI Cytoplasm {ECO 0000269|PubMed 1532388}. # SUPFAM SSF52172 SSF52172 # eggNOG COG0745 LUCA # eggNOG ENOG4105EEX Bacteria BLAST swissprot:KDPE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:KDPE_ECOLI BioCyc ECOL316407:JW5096-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5096-MONOMER BioCyc EcoCyc:KDPE-MONOMER http://biocyc.org/getid?id=EcoCyc:KDPE-MONOMER COG COG0745 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0745 DIP DIP-10063N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10063N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M36066 http://www.ebi.ac.uk/ena/data/view/M36066 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0512 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0512 EcoGene EG10517 http://www.ecogene.org/geneInfo.php?eg_id=EG10517 EnsemblBacteria AAC73788 http://www.ensemblgenomes.org/id/AAC73788 EnsemblBacteria AAC73788 http://www.ensemblgenomes.org/id/AAC73788 EnsemblBacteria BAA35351 http://www.ensemblgenomes.org/id/BAA35351 EnsemblBacteria BAA35351 http://www.ensemblgenomes.org/id/BAA35351 EnsemblBacteria BAA35351 http://www.ensemblgenomes.org/id/BAA35351 EnsemblBacteria b0694 http://www.ensemblgenomes.org/id/b0694 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000986 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000986 GO_function GO:0001131 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001131 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 945302 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945302 HOGENOM HOG000034815 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000034815&db=HOGENOM6 InParanoid P21866 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P21866 IntAct P21866 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P21866* InterPro IPR001789 http://www.ebi.ac.uk/interpro/entry/IPR001789 InterPro IPR001867 http://www.ebi.ac.uk/interpro/entry/IPR001867 InterPro IPR011006 http://www.ebi.ac.uk/interpro/entry/IPR011006 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW5096 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5096 KEGG_Gene eco:b0694 http://www.genome.jp/dbget-bin/www_bget?eco:b0694 KEGG_Orthology KO:K07667 http://www.genome.jp/dbget-bin/www_bget?KO:K07667 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA LEGEGCR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LEGEGCR PDB 1ZH2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZH2 PDB 1ZH4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZH4 PDB 3ZQ7 http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZQ7 PDB 4KFC http://www.ebi.ac.uk/pdbe-srv/view/entry/4KFC PDB 4KNY http://www.ebi.ac.uk/pdbe-srv/view/entry/4KNY PDB 4L85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4L85 PDBsum 1ZH2 http://www.ebi.ac.uk/pdbsum/1ZH2 PDBsum 1ZH4 http://www.ebi.ac.uk/pdbsum/1ZH4 PDBsum 3ZQ7 http://www.ebi.ac.uk/pdbsum/3ZQ7 PDBsum 4KFC http://www.ebi.ac.uk/pdbsum/4KFC PDBsum 4KNY http://www.ebi.ac.uk/pdbsum/4KNY PDBsum 4L85 http://www.ebi.ac.uk/pdbsum/4L85 PROSITE PS50110 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50110 PROSITE PS51755 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51755 PSORT swissprot:KDPE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:KDPE_ECOLI PSORT-B swissprot:KDPE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:KDPE_ECOLI PSORT2 swissprot:KDPE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:KDPE_ECOLI Pfam PF00072 http://pfam.xfam.org/family/PF00072 Pfam PF00486 http://pfam.xfam.org/family/PF00486 Phobius swissprot:KDPE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:KDPE_ECOLI PhylomeDB P21866 http://phylomedb.org/?seqid=P21866 ProteinModelPortal P21866 http://www.proteinmodelportal.org/query/uniprot/P21866 PubMed 1532388 http://www.ncbi.nlm.nih.gov/pubmed/1532388 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_415222 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415222 RefSeq WP_000186076 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000186076 SMART SM00448 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00448 SMART SM00862 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00862 SMR P21866 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P21866 STRING 511145.b0694 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0694&targetmode=cogs STRING COG0745 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0745&targetmode=cogs SUPFAM SSF52172 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52172 UniProtKB KDPE_ECOLI http://www.uniprot.org/uniprot/KDPE_ECOLI UniProtKB-AC P21866 http://www.uniprot.org/uniprot/P21866 charge swissprot:KDPE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:KDPE_ECOLI eggNOG COG0745 http://eggnogapi.embl.de/nog_data/html/tree/COG0745 eggNOG ENOG4105EEX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EEX epestfind swissprot:KDPE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:KDPE_ECOLI garnier swissprot:KDPE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:KDPE_ECOLI helixturnhelix swissprot:KDPE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:KDPE_ECOLI hmoment swissprot:KDPE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:KDPE_ECOLI iep swissprot:KDPE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:KDPE_ECOLI inforesidue swissprot:KDPE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:KDPE_ECOLI octanol swissprot:KDPE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:KDPE_ECOLI pepcoil swissprot:KDPE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:KDPE_ECOLI pepdigest swissprot:KDPE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:KDPE_ECOLI pepinfo swissprot:KDPE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:KDPE_ECOLI pepnet swissprot:KDPE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:KDPE_ECOLI pepstats swissprot:KDPE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:KDPE_ECOLI pepwheel swissprot:KDPE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:KDPE_ECOLI pepwindow swissprot:KDPE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:KDPE_ECOLI sigcleave swissprot:KDPE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:KDPE_ECOLI ## Database ID URL or Descriptions # BioGrid 4259215 237 # EcoGene EG13213 ypjA # GO_component GO:0009279 cell outer membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0007155 cell adhesion; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0007155 cell adhesion # Gene3D 2.160.20.20 -; 5. # Gene3D 2.40.128.130 -; 1. # InterPro IPR003991 Pertactin_virulence_factor # InterPro IPR004899 Pertactin_central # InterPro IPR005546 Autotransporte_beta # InterPro IPR006315 OM_autotransptr_brl # InterPro IPR011050 Pectin_lyase_fold/virulence # InterPro IPR012332 P22_tailspike_C-like # InterPro IPR030930 AIDA # Organism YPJA_ECOLI Escherichia coli (strain K12) # PATRIC 32120689 VBIEscCol129921_2743 # PIR A65044 A65044 # PRINTS PR01484 PRTACTNFAMLY # PROSITE PS51208 AUTOTRANSPORTER # Pfam PF03212 Pertactin # Pfam PF03797 Autotransporter # Pfam PF16168 AIDA; 6 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YPJA_ECOLI Uncharacterized outer membrane protein YpjA # RefSeq NP_417134 NC_000913.3 # SIMILARITY Contains 1 autotransporter (TC 1.B.12) domain. {ECO:0000255|PROSITE-ProRule PRU00556}. # SMART SM00869 Autotransporter # SUBCELLULAR LOCATION YPJA_ECOLI Cell outer membrane {ECO 0000305}; Peripheral membrane protein {ECO 0000305}. # SUPFAM SSF103515 SSF103515 # SUPFAM SSF51126 SSF51126 # TIGRFAMs TIGR01414 autotrans_barl # TIGRFAMs TIGR04415 O_hepto_targRPT; 6 # eggNOG ENOG4108MGN Bacteria # eggNOG ENOG4110GG4 LUCA BLAST swissprot:YPJA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YPJA_ECOLI BioCyc ECOL316407:JW5422-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5422-MONOMER BioCyc EcoCyc:G7382-MONOMER http://biocyc.org/getid?id=EcoCyc:G7382-MONOMER DIP DIP-12834N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12834N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36840 http://www.ebi.ac.uk/ena/data/view/U36840 EchoBASE EB3005 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3005 EcoGene EG13213 http://www.ecogene.org/geneInfo.php?eg_id=EG13213 EnsemblBacteria AAC75695 http://www.ensemblgenomes.org/id/AAC75695 EnsemblBacteria AAC75695 http://www.ensemblgenomes.org/id/AAC75695 EnsemblBacteria BAA16514 http://www.ensemblgenomes.org/id/BAA16514 EnsemblBacteria BAA16514 http://www.ensemblgenomes.org/id/BAA16514 EnsemblBacteria BAA16514 http://www.ensemblgenomes.org/id/BAA16514 EnsemblBacteria b2647 http://www.ensemblgenomes.org/id/b2647 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 Gene3D 2.160.20.20 http://www.cathdb.info/version/latest/superfamily/2.160.20.20 Gene3D 2.40.128.130 http://www.cathdb.info/version/latest/superfamily/2.40.128.130 GeneID 948630 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948630 HOGENOM HOG000009752 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009752&db=HOGENOM6 InParanoid P52143 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P52143 IntAct P52143 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P52143* InterPro IPR003991 http://www.ebi.ac.uk/interpro/entry/IPR003991 InterPro IPR004899 http://www.ebi.ac.uk/interpro/entry/IPR004899 InterPro IPR005546 http://www.ebi.ac.uk/interpro/entry/IPR005546 InterPro IPR006315 http://www.ebi.ac.uk/interpro/entry/IPR006315 InterPro IPR011050 http://www.ebi.ac.uk/interpro/entry/IPR011050 InterPro IPR012332 http://www.ebi.ac.uk/interpro/entry/IPR012332 InterPro IPR030930 http://www.ebi.ac.uk/interpro/entry/IPR030930 KEGG_Gene ecj:JW5422 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5422 KEGG_Gene eco:b2647 http://www.genome.jp/dbget-bin/www_bget?eco:b2647 MINT MINT-1218786 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1218786 OMA IEPTKTQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IEPTKTQ PRINTS PR01484 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01484 PROSITE PS51208 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51208 PSORT swissprot:YPJA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YPJA_ECOLI PSORT-B swissprot:YPJA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YPJA_ECOLI PSORT2 swissprot:YPJA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YPJA_ECOLI Pfam PF03212 http://pfam.xfam.org/family/PF03212 Pfam PF03797 http://pfam.xfam.org/family/PF03797 Pfam PF16168 http://pfam.xfam.org/family/PF16168 Phobius swissprot:YPJA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YPJA_ECOLI PhylomeDB P52143 http://phylomedb.org/?seqid=P52143 ProteinModelPortal P52143 http://www.proteinmodelportal.org/query/uniprot/P52143 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417134 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417134 SMART SM00869 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00869 SMR P52143 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P52143 STRING 511145.b2647 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2647&targetmode=cogs SUPFAM SSF103515 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103515 SUPFAM SSF51126 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51126 TIGRFAMs TIGR01414 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01414 TIGRFAMs TIGR04415 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR04415 UniProtKB YPJA_ECOLI http://www.uniprot.org/uniprot/YPJA_ECOLI UniProtKB-AC P52143 http://www.uniprot.org/uniprot/P52143 charge swissprot:YPJA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YPJA_ECOLI eggNOG ENOG4108MGN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MGN eggNOG ENOG4110GG4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4110GG4 epestfind swissprot:YPJA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YPJA_ECOLI garnier swissprot:YPJA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YPJA_ECOLI helixturnhelix swissprot:YPJA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YPJA_ECOLI hmoment swissprot:YPJA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YPJA_ECOLI iep swissprot:YPJA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YPJA_ECOLI inforesidue swissprot:YPJA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YPJA_ECOLI octanol swissprot:YPJA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YPJA_ECOLI pepcoil swissprot:YPJA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YPJA_ECOLI pepdigest swissprot:YPJA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YPJA_ECOLI pepinfo swissprot:YPJA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YPJA_ECOLI pepnet swissprot:YPJA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YPJA_ECOLI pepstats swissprot:YPJA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YPJA_ECOLI pepwheel swissprot:YPJA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YPJA_ECOLI pepwindow swissprot:YPJA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YPJA_ECOLI sigcleave swissprot:YPJA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YPJA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262310 16 # EcoGene EG11157 ygeA # GO_function GO:0047661 amino-acid racemase activity; IBA:GO_Central. # GO_process GO:0006520 cellular amino acid metabolic process; IEA:InterPro. # GO_process GO:0009252 peptidoglycan biosynthetic process; IBA:GO_Central. # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.1860 -; 2. # IntAct P03813 2 # InterPro IPR001920 Asp/Glu_race # InterPro IPR004380 Asp_race # InterPro IPR015942 Asp/Glu/hydantoin_racemase # InterPro IPR018187 Asp/Glu_racemase_AS_1 # InterPro IPR033134 Asp/Glu_racemase_AS_2 # Organism YGEA_ECOLI Escherichia coli (strain K12) # PATRIC 32121098 VBIEscCol129921_2938 # PIR A04438 QQECK # PROSITE PS00923 ASP_GLU_RACEMASE_1 # PROSITE PS00924 ASP_GLU_RACEMASE_2 # Pfam PF01177 Asp_Glu_race # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGEA_ECOLI Uncharacterized protein YgeA # RefSeq NP_417317 NC_000913.3 # RefSeq WP_000848659 NZ_LN832404.1 # SIMILARITY Belongs to the aspartate/glutamate racemases family. {ECO 0000305}. # SUPFAM SSF53681 SSF53681; 2 # TIGRFAMs TIGR00035 asp_race # eggNOG COG1794 LUCA # eggNOG ENOG4105CG9 Bacteria BLAST swissprot:YGEA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGEA_ECOLI BioCyc ECOL316407:JW2808-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2808-MONOMER BioCyc EcoCyc:EG11157-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11157-MONOMER DIP DIP-12147N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12147N DOI 10.1016/S0022-2836(83)80022-9 http://dx.doi.org/10.1016/S0022-2836(83)80022-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01614 http://www.ebi.ac.uk/ena/data/view/J01614 EMBL J03732 http://www.ebi.ac.uk/ena/data/view/J03732 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 EchoBASE EB1146 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1146 EcoGene EG11157 http://www.ecogene.org/geneInfo.php?eg_id=EG11157 EnsemblBacteria AAC75879 http://www.ensemblgenomes.org/id/AAC75879 EnsemblBacteria AAC75879 http://www.ensemblgenomes.org/id/AAC75879 EnsemblBacteria BAE76909 http://www.ensemblgenomes.org/id/BAE76909 EnsemblBacteria BAE76909 http://www.ensemblgenomes.org/id/BAE76909 EnsemblBacteria BAE76909 http://www.ensemblgenomes.org/id/BAE76909 EnsemblBacteria b2840 http://www.ensemblgenomes.org/id/b2840 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0047661 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047661 GO_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GO_process GO:0009252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009252 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.1860 http://www.cathdb.info/version/latest/superfamily/3.40.50.1860 GeneID 947348 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947348 HOGENOM HOG000262146 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000262146&db=HOGENOM6 InParanoid P03813 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P03813 IntAct P03813 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P03813* InterPro IPR001920 http://www.ebi.ac.uk/interpro/entry/IPR001920 InterPro IPR004380 http://www.ebi.ac.uk/interpro/entry/IPR004380 InterPro IPR015942 http://www.ebi.ac.uk/interpro/entry/IPR015942 InterPro IPR018187 http://www.ebi.ac.uk/interpro/entry/IPR018187 InterPro IPR033134 http://www.ebi.ac.uk/interpro/entry/IPR033134 KEGG_Gene ecj:JW2808 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2808 KEGG_Gene eco:b2840 http://www.genome.jp/dbget-bin/www_bget?eco:b2840 OMA VICTNTM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VICTNTM PROSITE PS00923 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00923 PROSITE PS00924 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00924 PSORT swissprot:YGEA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGEA_ECOLI PSORT-B swissprot:YGEA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGEA_ECOLI PSORT2 swissprot:YGEA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGEA_ECOLI Pfam PF01177 http://pfam.xfam.org/family/PF01177 Phobius swissprot:YGEA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGEA_ECOLI PhylomeDB P03813 http://phylomedb.org/?seqid=P03813 ProteinModelPortal P03813 http://www.proteinmodelportal.org/query/uniprot/P03813 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2836407 http://www.ncbi.nlm.nih.gov/pubmed/2836407 PubMed 6350602 http://www.ncbi.nlm.nih.gov/pubmed/6350602 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417317 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417317 RefSeq WP_000848659 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000848659 SMR P03813 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P03813 STRING 511145.b2840 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2840&targetmode=cogs SUPFAM SSF53681 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53681 TIGRFAMs TIGR00035 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00035 UniProtKB YGEA_ECOLI http://www.uniprot.org/uniprot/YGEA_ECOLI UniProtKB-AC P03813 http://www.uniprot.org/uniprot/P03813 charge swissprot:YGEA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGEA_ECOLI eggNOG COG1794 http://eggnogapi.embl.de/nog_data/html/tree/COG1794 eggNOG ENOG4105CG9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CG9 epestfind swissprot:YGEA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGEA_ECOLI garnier swissprot:YGEA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGEA_ECOLI helixturnhelix swissprot:YGEA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGEA_ECOLI hmoment swissprot:YGEA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGEA_ECOLI iep swissprot:YGEA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGEA_ECOLI inforesidue swissprot:YGEA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGEA_ECOLI octanol swissprot:YGEA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGEA_ECOLI pepcoil swissprot:YGEA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGEA_ECOLI pepdigest swissprot:YGEA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGEA_ECOLI pepinfo swissprot:YGEA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGEA_ECOLI pepnet swissprot:YGEA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGEA_ECOLI pepstats swissprot:YGEA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGEA_ECOLI pepwheel swissprot:YGEA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGEA_ECOLI pepwindow swissprot:YGEA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGEA_ECOLI sigcleave swissprot:YGEA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGEA_ECOLI ## Database ID URL or Descriptions # AltName EIIC-Chb {ECO:0000303|PubMed 2092358} # AltName IIcel {ECO:0000303|PubMed 2179047} # AltName N,N'-diacetylchitobiose-specific phosphotransferase enzyme IIC component {ECO:0000303|PubMed 2092358} # BioGrid 4260315 19 # CAUTION Was originally (PubMed:2179047) characterized as part of a cryptic cel operon for a cellobiose degradation system. The Cel+ phenotype is due to mutations making expression chitobiose- independent and altering the substrate specificity. {ECO 0000305|PubMed:2179047}. # DOMAIN PTQC_ECOLI The EIIC type-3 domain forms the PTS system translocation channel and contains the specific substrate-binding site. {ECO 0000255|PROSITE-ProRule PRU00428}. # EcoGene EG10141 chbC # FUNCTION PTQC_ECOLI The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ChbABC PTS system is involved in the transport of the chitin disaccharide N,N'-diacetylchitobiose (GlcNAc2) (PubMed 10913117). Also able to use N,N',N''-triacetyl chitotriose (GlcNAc3) (PubMed 10913117). {ECO 0000269|PubMed 10913117, ECO 0000305|PubMed 2092358}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0008982 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:InterPro. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW. # GO_process GO:1902815 N,N'-diacetylchitobiose import; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # INDUCTION By GlcNAc2, GlcNAc3 and beta-N,N'-diacetylchitobiose (Me-TCB). {ECO:0000269|PubMed 10913117}. # InterPro IPR003352 PTS_EIIC # InterPro IPR004501 PTS_EIIC_3 # InterPro IPR004796 PTS_IIC_cello # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00275 PTS system, cellobiose-specific II component # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02060 Phosphotransferase system (PTS) # Organism PTQC_ECOLI Escherichia coli (strain K12) # PATRIC 32118783 VBIEscCol129921_1809 # PIR A64933 A64933 # PIR S10871 S10871 # PIRSF PIRSF006351 PTS_EIIC-Cellobiose # PROSITE PS51105 PTS_EIIC_TYPE_3 # Pfam PF02378 PTS_EIIC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PTS system N,N'-diacetylchitobiose-specific EIIC component {ECO:0000303|PubMed 2092358} # RefSeq NP_416251 NC_000913.3 # RefSeq WP_000073041 NZ_LN832404.1 # SIMILARITY Contains 1 PTS EIIC type-3 domain. {ECO:0000255|PROSITE-ProRule PRU00428}. # SUBCELLULAR LOCATION PTQC_ECOLI Cell inner membrane {ECO 0000255|PROSITE- ProRule PRU00428}; Multi-pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00428}. # TCDB 4.A.3.2 the pts lactose-n,n'-diacetylchitobiose-Beta-glucoside (lac) family # TIGRFAMs TIGR00359 cello_pts_IIC # TIGRFAMs TIGR00410 lacE # eggNOG COG1455 LUCA # eggNOG ENOG4105CK1 Bacteria BLAST swissprot:PTQC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTQC_ECOLI BioCyc ECOL316407:JW1726-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1726-MONOMER BioCyc EcoCyc:CELB-MONOMER http://biocyc.org/getid?id=EcoCyc:CELB-MONOMER BioCyc MetaCyc:CELB-MONOMER http://biocyc.org/getid?id=MetaCyc:CELB-MONOMER COG COG1455 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1455 DIP DIP-9264N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9264N DOI 10.1016/0923-2508(90)90079-6 http://dx.doi.org/10.1016/0923-2508(90)90079-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.94.26.14367 http://dx.doi.org/10.1073/pnas.94.26.14367 DOI 10.1074/jbc.M001043200 http://dx.doi.org/10.1074/jbc.M001043200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X52890 http://www.ebi.ac.uk/ena/data/view/X52890 EchoBASE EB0139 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0139 EcoGene EG10141 http://www.ecogene.org/geneInfo.php?eg_id=EG10141 EnsemblBacteria AAC74807 http://www.ensemblgenomes.org/id/AAC74807 EnsemblBacteria AAC74807 http://www.ensemblgenomes.org/id/AAC74807 EnsemblBacteria BAA15518 http://www.ensemblgenomes.org/id/BAA15518 EnsemblBacteria BAA15518 http://www.ensemblgenomes.org/id/BAA15518 EnsemblBacteria BAA15518 http://www.ensemblgenomes.org/id/BAA15518 EnsemblBacteria b1737 http://www.ensemblgenomes.org/id/b1737 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008982 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008982 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GO_process GO:1902815 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902815 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 945982 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945982 HOGENOM HOG000224102 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000224102&db=HOGENOM6 InParanoid P17334 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P17334 IntAct P17334 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P17334* InterPro IPR003352 http://www.ebi.ac.uk/interpro/entry/IPR003352 InterPro IPR004501 http://www.ebi.ac.uk/interpro/entry/IPR004501 InterPro IPR004796 http://www.ebi.ac.uk/interpro/entry/IPR004796 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1726 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1726 KEGG_Gene eco:b1737 http://www.genome.jp/dbget-bin/www_bget?eco:b1737 KEGG_Orthology KO:K02761 http://www.genome.jp/dbget-bin/www_bget?KO:K02761 KEGG_Pathway ko02060 http://www.genome.jp/kegg-bin/show_pathway?ko02060 OMA MAIKLPE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MAIKLPE PROSITE PS51105 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51105 PSORT swissprot:PTQC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTQC_ECOLI PSORT-B swissprot:PTQC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTQC_ECOLI PSORT2 swissprot:PTQC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTQC_ECOLI Pfam PF02378 http://pfam.xfam.org/family/PF02378 Phobius swissprot:PTQC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTQC_ECOLI PhylomeDB P17334 http://phylomedb.org/?seqid=P17334 ProteinModelPortal P17334 http://www.proteinmodelportal.org/query/uniprot/P17334 PubMed 10913117 http://www.ncbi.nlm.nih.gov/pubmed/10913117 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2092358 http://www.ncbi.nlm.nih.gov/pubmed/2092358 PubMed 2179047 http://www.ncbi.nlm.nih.gov/pubmed/2179047 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9405618 http://www.ncbi.nlm.nih.gov/pubmed/9405618 RefSeq NP_416251 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416251 RefSeq WP_000073041 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000073041 STRING 511145.b1737 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1737&targetmode=cogs STRING COG1455 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1455&targetmode=cogs TCDB 4.A.3.2 http://www.tcdb.org/search/result.php?tc=4.A.3.2 TIGRFAMs TIGR00359 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00359 TIGRFAMs TIGR00410 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00410 UniProtKB PTQC_ECOLI http://www.uniprot.org/uniprot/PTQC_ECOLI UniProtKB-AC P17334 http://www.uniprot.org/uniprot/P17334 charge swissprot:PTQC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTQC_ECOLI eggNOG COG1455 http://eggnogapi.embl.de/nog_data/html/tree/COG1455 eggNOG ENOG4105CK1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CK1 epestfind swissprot:PTQC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTQC_ECOLI garnier swissprot:PTQC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTQC_ECOLI helixturnhelix swissprot:PTQC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTQC_ECOLI hmoment swissprot:PTQC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTQC_ECOLI iep swissprot:PTQC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTQC_ECOLI inforesidue swissprot:PTQC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTQC_ECOLI octanol swissprot:PTQC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTQC_ECOLI pepcoil swissprot:PTQC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTQC_ECOLI pepdigest swissprot:PTQC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTQC_ECOLI pepinfo swissprot:PTQC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTQC_ECOLI pepnet swissprot:PTQC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTQC_ECOLI pepstats swissprot:PTQC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTQC_ECOLI pepwheel swissprot:PTQC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTQC_ECOLI pepwindow swissprot:PTQC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTQC_ECOLI sigcleave swissprot:PTQC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTQC_ECOLI ## Database ID URL or Descriptions # AltName GSA_ECOLI Glutamate-1-semialdehyde aminotransferase # CATALYTIC ACTIVITY GSA_ECOLI (S)-4-amino-5-oxopentanoate = 5- aminolevulinate. # CDD cd00610 OAT_like # COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI 597326; # EcoGene EG10432 hemL # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0008483 transaminase activity; IEA:InterPro. # GO_function GO:0030170 pyridoxal phosphate binding; IBA:GO_Central. # GO_function GO:0042286 glutamate-1-semialdehyde 2,1-aminomutase activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0006782 protoporphyrinogen IX biosynthetic process; IDA:EcoCyc. # GO_process GO:0033014 tetrapyrrole biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.640.10 -; 1. # Gene3D 3.90.1150.10 -; 2. # HAMAP MF_00375 HemL_aminotrans_3 # INDUCTION Induced by low extracellular levels of magnesium via the PhoQ/PhoP two-component regulatory system. {ECO:0000269|PubMed 12813061}. # INTERACTION GSA_ECOLI P0ACL5 glcC; NbExp=4; IntAct=EBI-909193, EBI-1115389; # IntAct P23893 2 # InterPro IPR004639 4pyrrol_synth_GluAld_NH2Trfase # InterPro IPR005814 Aminotrans_3 # InterPro IPR015421 PyrdxlP-dep_Trfase_major_sub1 # InterPro IPR015422 PyrdxlP-dep_Trfase_major_sub2 # InterPro IPR015424 PyrdxlP-dep_Trfase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01007 Amino acid related enzymes # KEGG_Pathway ko00860 Porphyrin and chlorophyll metabolism # Organism GSA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11986 PTHR11986 # PATHWAY Porphyrin-containing compound metabolism; protoporphyrin- IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu) step 2/2. # PATRIC 32115417 VBIEscCol129921_0160 # PIR B64739 B64739 # PROSITE PS00600 AA_TRANSFER_CLASS_3 # Pfam PF00202 Aminotran_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GSA_ECOLI Glutamate-1-semialdehyde 2,1-aminomutase # RefSeq NP_414696 NC_000913.3 # RefSeq WP_000045315 NZ_LN832404.1 # SIMILARITY Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION GSA_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT GSA_ECOLI Homodimer. # SUPFAM SSF53383 SSF53383 # TIGRFAMs TIGR00713 hemL # UniPathway UPA00251 UER00317 # eggNOG COG0001 LUCA # eggNOG ENOG4105CDM Bacteria BLAST swissprot:GSA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GSA_ECOLI BioCyc ECOL316407:JW0150-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0150-MONOMER BioCyc EcoCyc:GSAAMINOTRANS-MONOMER http://biocyc.org/getid?id=EcoCyc:GSAAMINOTRANS-MONOMER BioCyc MetaCyc:GSAAMINOTRANS-MONOMER http://biocyc.org/getid?id=MetaCyc:GSAAMINOTRANS-MONOMER COG COG0001 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0001 DIP DIP-9886N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9886N DOI 10.1007/BF00282635 http://dx.doi.org/10.1007/BF00282635 DOI 10.1021/bi00146a016 http://dx.doi.org/10.1021/bi00146a016 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.185.13.3696-3702.2003 http://dx.doi.org/10.1128/JB.185.13.3696-3702.2003 EC_number EC:5.4.3.8 http://www.genome.jp/dbget-bin/www_bget?EC:5.4.3.8 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EMBL X53696 http://www.ebi.ac.uk/ena/data/view/X53696 ENZYME 5.4.3.8 http://enzyme.expasy.org/EC/5.4.3.8 EchoBASE EB0427 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0427 EcoGene EG10432 http://www.ecogene.org/geneInfo.php?eg_id=EG10432 EnsemblBacteria AAC73265 http://www.ensemblgenomes.org/id/AAC73265 EnsemblBacteria AAC73265 http://www.ensemblgenomes.org/id/AAC73265 EnsemblBacteria BAB96731 http://www.ensemblgenomes.org/id/BAB96731 EnsemblBacteria BAB96731 http://www.ensemblgenomes.org/id/BAB96731 EnsemblBacteria BAB96731 http://www.ensemblgenomes.org/id/BAB96731 EnsemblBacteria b0154 http://www.ensemblgenomes.org/id/b0154 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008483 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008483 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_function GO:0042286 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042286 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0006782 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006782 GO_process GO:0033014 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033014 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.640.10 http://www.cathdb.info/version/latest/superfamily/3.40.640.10 Gene3D 3.90.1150.10 http://www.cathdb.info/version/latest/superfamily/3.90.1150.10 GeneID 946892 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946892 HAMAP MF_00375 http://hamap.expasy.org/unirule/MF_00375 HOGENOM HOG000020210 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000020210&db=HOGENOM6 InParanoid P23893 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23893 IntAct P23893 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P23893* IntEnz 5.4.3.8 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.4.3.8 InterPro IPR004639 http://www.ebi.ac.uk/interpro/entry/IPR004639 InterPro IPR005814 http://www.ebi.ac.uk/interpro/entry/IPR005814 InterPro IPR015421 http://www.ebi.ac.uk/interpro/entry/IPR015421 InterPro IPR015422 http://www.ebi.ac.uk/interpro/entry/IPR015422 InterPro IPR015424 http://www.ebi.ac.uk/interpro/entry/IPR015424 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Gene ecj:JW0150 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0150 KEGG_Gene eco:b0154 http://www.genome.jp/dbget-bin/www_bget?eco:b0154 KEGG_Orthology KO:K01845 http://www.genome.jp/dbget-bin/www_bget?KO:K01845 KEGG_Pathway ko00860 http://www.genome.jp/kegg-bin/show_pathway?ko00860 KEGG_Reaction rn:R02272 http://www.genome.jp/dbget-bin/www_bget?rn:R02272 OMA CGHAHPE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CGHAHPE PANTHER PTHR11986 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11986 PROSITE PS00600 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00600 PSORT swissprot:GSA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GSA_ECOLI PSORT-B swissprot:GSA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GSA_ECOLI PSORT2 swissprot:GSA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GSA_ECOLI Pfam PF00202 http://pfam.xfam.org/family/PF00202 Phobius swissprot:GSA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GSA_ECOLI PhylomeDB P23893 http://phylomedb.org/?seqid=P23893 ProteinModelPortal P23893 http://www.proteinmodelportal.org/query/uniprot/P23893 PubMed 12813061 http://www.ncbi.nlm.nih.gov/pubmed/12813061 PubMed 1643048 http://www.ncbi.nlm.nih.gov/pubmed/1643048 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1900346 http://www.ncbi.nlm.nih.gov/pubmed/1900346 PubMed 2045363 http://www.ncbi.nlm.nih.gov/pubmed/2045363 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414696 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414696 RefSeq WP_000045315 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000045315 SMR P23893 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P23893 STRING 511145.b0154 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0154&targetmode=cogs STRING COG0001 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0001&targetmode=cogs SUPFAM SSF53383 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53383 TIGRFAMs TIGR00713 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00713 UniProtKB GSA_ECOLI http://www.uniprot.org/uniprot/GSA_ECOLI UniProtKB-AC P23893 http://www.uniprot.org/uniprot/P23893 charge swissprot:GSA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GSA_ECOLI eggNOG COG0001 http://eggnogapi.embl.de/nog_data/html/tree/COG0001 eggNOG ENOG4105CDM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CDM epestfind swissprot:GSA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GSA_ECOLI garnier swissprot:GSA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GSA_ECOLI helixturnhelix swissprot:GSA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GSA_ECOLI hmoment swissprot:GSA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GSA_ECOLI iep swissprot:GSA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GSA_ECOLI inforesidue swissprot:GSA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GSA_ECOLI octanol swissprot:GSA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GSA_ECOLI pepcoil swissprot:GSA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GSA_ECOLI pepdigest swissprot:GSA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GSA_ECOLI pepinfo swissprot:GSA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GSA_ECOLI pepnet swissprot:GSA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GSA_ECOLI pepstats swissprot:GSA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GSA_ECOLI pepwheel swissprot:GSA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GSA_ECOLI pepwindow swissprot:GSA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GSA_ECOLI sigcleave swissprot:GSA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GSA_ECOLI ## Database ID URL or Descriptions # AltName SELB_ECOLI SelB translation factor # BioGrid 4261875 4 # EcoGene EG10942 selB # FUNCTION SELB_ECOLI Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP. # GO_component GO:0005622 intracellular; IBA:GO_Central. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0000049 tRNA binding; IDA:EcoCyc. # GO_function GO:0003746 translation elongation factor activity; IEA:InterPro. # GO_function GO:0003924 GTPase activity; IDA:EcoCyc. # GO_function GO:0005525 GTP binding; IDA:EcoCyc. # GO_function GO:0019003 GDP binding; IDA:EcoCyc. # GO_function GO:0035368 selenocysteine insertion sequence binding; IDA:EcoCyc. # GO_process GO:0001514 selenocysteine incorporation; IMP:EcoCyc. # GO_process GO:0016259 selenocysteine metabolic process; IMP:EcoCyc. # GOslim_component GO:0005622 intracellular # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0003729 mRNA binding # GOslim_function GO:0003924 GTPase activity # GOslim_function GO:0008135 translation factor activity, RNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 1.10.10.10 -; 2. # Gene3D 3.40.50.300 -; 1. # IntAct P14081 42 # InterPro IPR000795 TF_GTP-bd_dom # InterPro IPR004161 EFTu-like_2 # InterPro IPR004535 Transl_elong_SelB # InterPro IPR009000 Transl_B-barrel # InterPro IPR009001 Transl_elong_EF1A/Init_IF2_C # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR015190 Elong_fac_SelB-wing-hlx_typ-2 # InterPro IPR015191 Elong_fac_SelB-wing-hlx_typ-3 # InterPro IPR027417 P-loop_NTPase # InterPro IPR031157 G_TR_CS # KEGG_Brite ko03012 Translation factors # MISCELLANEOUS SELB_ECOLI There are about 1100 copies of SelB per E.coli cell. # Organism SELB_ECOLI Escherichia coli (strain K12) # PATRIC 32122658 VBIEscCol129921_3706 # PDB 2PJP X-ray; 2.30 A; A=487-607 # PIR JV0050 EFECSB # PRINTS PR00315 ELONGATNFCT # PROSITE PS00301 G_TR_1 # PROSITE PS51722 G_TR_2 # Pfam PF03144 GTP_EFTU_D2 # Pfam PF09106 SelB-wing_2 # Pfam PF09107 SelB-wing_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SELB_ECOLI Selenocysteine-specific elongation factor # RefSeq NP_418047 NC_000913.3 # RefSeq WP_000582468 NZ_LN832404.1 # SIMILARITY Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. SelB subfamily. {ECO:0000255|PROSITE-ProRule PRU01059}. # SIMILARITY Contains 1 tr-type G (guanine nucleotide-binding) domain. {ECO:0000255|PROSITE-ProRule PRU01059}. # SUBCELLULAR LOCATION SELB_ECOLI Cytoplasm. # SUPFAM SSF46785 SSF46785; 3 # SUPFAM SSF50447 SSF50447 # SUPFAM SSF50465 SSF50465 # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR00475 selB # eggNOG COG3276 LUCA # eggNOG ENOG4105EM7 Bacteria BLAST swissprot:SELB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SELB_ECOLI BioCyc ECOL316407:JW3563-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3563-MONOMER BioCyc EcoCyc:EG10942-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10942-MONOMER BioCyc MetaCyc:EG10942-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10942-MONOMER COG COG3276 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3276 DIP DIP-10848N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10848N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/342453a0 http://dx.doi.org/10.1038/342453a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X16644 http://www.ebi.ac.uk/ena/data/view/X16644 EchoBASE EB0935 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0935 EcoGene EG10942 http://www.ecogene.org/geneInfo.php?eg_id=EG10942 EnsemblBacteria AAC76614 http://www.ensemblgenomes.org/id/AAC76614 EnsemblBacteria AAC76614 http://www.ensemblgenomes.org/id/AAC76614 EnsemblBacteria BAE77703 http://www.ensemblgenomes.org/id/BAE77703 EnsemblBacteria BAE77703 http://www.ensemblgenomes.org/id/BAE77703 EnsemblBacteria BAE77703 http://www.ensemblgenomes.org/id/BAE77703 EnsemblBacteria b3590 http://www.ensemblgenomes.org/id/b3590 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000049 GO_function GO:0003746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003746 GO_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_function GO:0019003 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019003 GO_function GO:0035368 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035368 GO_process GO:0001514 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001514 GO_process GO:0016259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016259 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0003729 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003729 GOslim_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GOslim_function GO:0008135 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008135 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948103 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948103 HOGENOM HOG000163837 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000163837&db=HOGENOM6 InParanoid P14081 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P14081 IntAct P14081 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P14081* InterPro IPR000795 http://www.ebi.ac.uk/interpro/entry/IPR000795 InterPro IPR004161 http://www.ebi.ac.uk/interpro/entry/IPR004161 InterPro IPR004535 http://www.ebi.ac.uk/interpro/entry/IPR004535 InterPro IPR009000 http://www.ebi.ac.uk/interpro/entry/IPR009000 InterPro IPR009001 http://www.ebi.ac.uk/interpro/entry/IPR009001 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR015190 http://www.ebi.ac.uk/interpro/entry/IPR015190 InterPro IPR015191 http://www.ebi.ac.uk/interpro/entry/IPR015191 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR031157 http://www.ebi.ac.uk/interpro/entry/IPR031157 KEGG_Brite ko03012 http://www.genome.jp/dbget-bin/www_bget?ko03012 KEGG_Gene ecj:JW3563 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3563 KEGG_Gene eco:b3590 http://www.genome.jp/dbget-bin/www_bget?eco:b3590 KEGG_Orthology KO:K03833 http://www.genome.jp/dbget-bin/www_bget?KO:K03833 MINT MINT-1221874 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1221874 OMA YAIDRVF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YAIDRVF PDB 2PJP http://www.ebi.ac.uk/pdbe-srv/view/entry/2PJP PDBsum 2PJP http://www.ebi.ac.uk/pdbsum/2PJP PRINTS PR00315 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00315 PROSITE PS00301 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00301 PROSITE PS51722 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51722 PSORT swissprot:SELB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SELB_ECOLI PSORT-B swissprot:SELB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SELB_ECOLI PSORT2 swissprot:SELB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SELB_ECOLI Pfam PF03144 http://pfam.xfam.org/family/PF03144 Pfam PF09106 http://pfam.xfam.org/family/PF09106 Pfam PF09107 http://pfam.xfam.org/family/PF09107 Phobius swissprot:SELB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SELB_ECOLI PhylomeDB P14081 http://phylomedb.org/?seqid=P14081 ProteinModelPortal P14081 http://www.proteinmodelportal.org/query/uniprot/P14081 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2140572 http://www.ncbi.nlm.nih.gov/pubmed/2140572 PubMed 2531290 http://www.ncbi.nlm.nih.gov/pubmed/2531290 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_418047 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418047 RefSeq WP_000582468 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000582468 SMR P14081 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P14081 STRING 511145.b3590 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3590&targetmode=cogs STRING COG3276 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3276&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SUPFAM SSF50447 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50447 SUPFAM SSF50465 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50465 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR00475 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00475 UniProtKB SELB_ECOLI http://www.uniprot.org/uniprot/SELB_ECOLI UniProtKB-AC P14081 http://www.uniprot.org/uniprot/P14081 charge swissprot:SELB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SELB_ECOLI eggNOG COG3276 http://eggnogapi.embl.de/nog_data/html/tree/COG3276 eggNOG ENOG4105EM7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EM7 epestfind swissprot:SELB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SELB_ECOLI garnier swissprot:SELB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SELB_ECOLI helixturnhelix swissprot:SELB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SELB_ECOLI hmoment swissprot:SELB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SELB_ECOLI iep swissprot:SELB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SELB_ECOLI inforesidue swissprot:SELB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SELB_ECOLI octanol swissprot:SELB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SELB_ECOLI pepcoil swissprot:SELB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SELB_ECOLI pepdigest swissprot:SELB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SELB_ECOLI pepinfo swissprot:SELB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SELB_ECOLI pepnet swissprot:SELB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SELB_ECOLI pepstats swissprot:SELB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SELB_ECOLI pepwheel swissprot:SELB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SELB_ECOLI pepwindow swissprot:SELB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SELB_ECOLI sigcleave swissprot:SELB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SELB_ECOLI ## Database ID URL or Descriptions # BioGrid 4262999 21 # EcoGene EG11123 yciC # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # HAMAP MF_01067 UPF0259 # InterPro IPR009627 UPF0259 # Organism YCIC_ECOLI Escherichia coli (strain K12) # PATRIC 32117770 VBIEscCol129921_1305 # PIR B64873 B64873 # PIR T45502 T45502 # Pfam PF06790 UPF0259 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCIC_ECOLI UPF0259 membrane protein YciC # RefSeq NP_415771 NC_000913.3 # RefSeq WP_000028545 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0259 family. {ECO 0000305}. # SUBCELLULAR LOCATION YCIC_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG ENOG4108S3I Bacteria # eggNOG ENOG410XRTM LUCA BLAST swissprot:YCIC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCIC_ECOLI BioCyc ECOL316407:JW1247-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1247-MONOMER BioCyc EcoCyc:EG11123-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11123-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U24195 http://www.ebi.ac.uk/ena/data/view/U24195 EMBL U24196 http://www.ebi.ac.uk/ena/data/view/U24196 EMBL U24197 http://www.ebi.ac.uk/ena/data/view/U24197 EMBL U24198 http://www.ebi.ac.uk/ena/data/view/U24198 EMBL U24199 http://www.ebi.ac.uk/ena/data/view/U24199 EMBL U24200 http://www.ebi.ac.uk/ena/data/view/U24200 EMBL U24201 http://www.ebi.ac.uk/ena/data/view/U24201 EMBL U24202 http://www.ebi.ac.uk/ena/data/view/U24202 EMBL U24203 http://www.ebi.ac.uk/ena/data/view/U24203 EMBL U24204 http://www.ebi.ac.uk/ena/data/view/U24204 EMBL U24205 http://www.ebi.ac.uk/ena/data/view/U24205 EMBL U24206 http://www.ebi.ac.uk/ena/data/view/U24206 EMBL X13583 http://www.ebi.ac.uk/ena/data/view/X13583 EchoBASE EB1113 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1113 EcoGene EG11123 http://www.ecogene.org/geneInfo.php?eg_id=EG11123 EnsemblBacteria AAC74337 http://www.ensemblgenomes.org/id/AAC74337 EnsemblBacteria AAC74337 http://www.ensemblgenomes.org/id/AAC74337 EnsemblBacteria BAA14787 http://www.ensemblgenomes.org/id/BAA14787 EnsemblBacteria BAA14787 http://www.ensemblgenomes.org/id/BAA14787 EnsemblBacteria BAA14787 http://www.ensemblgenomes.org/id/BAA14787 EnsemblBacteria b1255 http://www.ensemblgenomes.org/id/b1255 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 945844 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945844 HAMAP MF_01067 http://hamap.expasy.org/unirule/MF_01067 InterPro IPR009627 http://www.ebi.ac.uk/interpro/entry/IPR009627 KEGG_Gene ecj:JW1247 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1247 KEGG_Gene eco:b1255 http://www.genome.jp/dbget-bin/www_bget?eco:b1255 OMA FFRNQFV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FFRNQFV PSORT swissprot:YCIC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCIC_ECOLI PSORT-B swissprot:YCIC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCIC_ECOLI PSORT2 swissprot:YCIC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCIC_ECOLI Pfam PF06790 http://pfam.xfam.org/family/PF06790 Phobius swissprot:YCIC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCIC_ECOLI ProteinModelPortal P21365 http://www.proteinmodelportal.org/query/uniprot/P21365 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3058546 http://www.ncbi.nlm.nih.gov/pubmed/3058546 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415771 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415771 RefSeq WP_000028545 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000028545 STRING 511145.b1255 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1255&targetmode=cogs UniProtKB YCIC_ECOLI http://www.uniprot.org/uniprot/YCIC_ECOLI UniProtKB-AC P21365 http://www.uniprot.org/uniprot/P21365 charge swissprot:YCIC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCIC_ECOLI eggNOG ENOG4108S3I http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108S3I eggNOG ENOG410XRTM http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRTM epestfind swissprot:YCIC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCIC_ECOLI garnier swissprot:YCIC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCIC_ECOLI helixturnhelix swissprot:YCIC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCIC_ECOLI hmoment swissprot:YCIC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCIC_ECOLI iep swissprot:YCIC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCIC_ECOLI inforesidue swissprot:YCIC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCIC_ECOLI octanol swissprot:YCIC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCIC_ECOLI pepcoil swissprot:YCIC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCIC_ECOLI pepdigest swissprot:YCIC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCIC_ECOLI pepinfo swissprot:YCIC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCIC_ECOLI pepnet swissprot:YCIC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCIC_ECOLI pepstats swissprot:YCIC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCIC_ECOLI pepwheel swissprot:YCIC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCIC_ECOLI pepwindow swissprot:YCIC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCIC_ECOLI sigcleave swissprot:YCIC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCIC_ECOLI ## Database ID URL or Descriptions # AltName GNTU_ECOLI Gluconate permease # AltName GNTU_ECOLI Gnt-I system # BioGrid 4261494 5 # EcoGene EG12631 gntU # FUNCTION GNTU_ECOLI Part of the gluconate utilization system Gnt-I; low- affinity intake of gluconate. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoliWiki. # GO_function GNTU_ECOLI GO 0005402 cation sugar symporter activity; IDA EcoCyc. # GO_function GO:0015128 gluconate transmembrane transporter activity; IEA:InterPro. # GO_process GO:0019521 D-gluconate metabolic process; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0044281 small molecule metabolic process # InterPro IPR003474 Glcn_transporter # KEGG_Brite ko02000 Transporters # Organism GNTU_ECOLI Escherichia coli (strain K12) # PATRIC 32122310 VBIEscCol129921_3532 # PIR JC4989 JC4989 # PIRSF PIRSF002746 Gluconate_transporter # Pfam PF02447 GntP_permease # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GNTU_ECOLI Low-affinity gluconate transporter # RefSeq WP_000210111 NZ_LN832404.1 # RefSeq YP_026221 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA58233.1; Type=Frameshift; Positions=332; Evidence={ECO:0000305}; Sequence=AAA58234.1; Type=Frameshift; Positions=332; Evidence={ECO 0000305}; # SIMILARITY Belongs to the GntP permease family. {ECO 0000305}. # SUBCELLULAR LOCATION GNTU_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.8.1:the gluconate h(+) symporter (gntp) family # TIGRFAMs TIGR00791 gntP # eggNOG COG2610 LUCA # eggNOG ENOG4105C6Z Bacteria BLAST swissprot:GNTU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GNTU_ECOLI BioCyc ECOL316407:JW5686-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5686-MONOMER BioCyc EcoCyc:GNTU-MONOMER http://biocyc.org/getid?id=EcoCyc:GNTU-MONOMER BioCyc MetaCyc:GNTU-MONOMER http://biocyc.org/getid?id=MetaCyc:GNTU-MONOMER COG COG2610 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2610 DOI 10.1006/jmbi.1996.0913 http://dx.doi.org/10.1006/jmbi.1996.0913 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1271/bbb.60.1548 http://dx.doi.org/10.1271/bbb.60.1548 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D84362 http://www.ebi.ac.uk/ena/data/view/D84362 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2515 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2515 EcoGene EG12631 http://www.ecogene.org/geneInfo.php?eg_id=EG12631 EnsemblBacteria AAT48183 http://www.ensemblgenomes.org/id/AAT48183 EnsemblBacteria AAT48183 http://www.ensemblgenomes.org/id/AAT48183 EnsemblBacteria BAE77857 http://www.ensemblgenomes.org/id/BAE77857 EnsemblBacteria BAE77857 http://www.ensemblgenomes.org/id/BAE77857 EnsemblBacteria BAE77857 http://www.ensemblgenomes.org/id/BAE77857 EnsemblBacteria b4476 http://www.ensemblgenomes.org/id/b4476 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0005402 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005402 GO_function GO:0015128 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015128 GO_process GO:0019521 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019521 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 2847760 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2847760 HOGENOM HOG000237114 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000237114&db=HOGENOM6 InParanoid P0AC96 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AC96 InterPro IPR003474 http://www.ebi.ac.uk/interpro/entry/IPR003474 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5686 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5686 KEGG_Gene eco:b4476 http://www.genome.jp/dbget-bin/www_bget?eco:b4476 KEGG_Orthology KO:K06156 http://www.genome.jp/dbget-bin/www_bget?KO:K06156 OMA PLCKAIS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PLCKAIS PSORT swissprot:GNTU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GNTU_ECOLI PSORT-B swissprot:GNTU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GNTU_ECOLI PSORT2 swissprot:GNTU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GNTU_ECOLI Pfam PF02447 http://pfam.xfam.org/family/PF02447 Phobius swissprot:GNTU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GNTU_ECOLI PhylomeDB P0AC96 http://phylomedb.org/?seqid=P0AC96 ProteinModelPortal P0AC96 http://www.proteinmodelportal.org/query/uniprot/P0AC96 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8655507 http://www.ncbi.nlm.nih.gov/pubmed/8655507 PubMed 8987614 http://www.ncbi.nlm.nih.gov/pubmed/8987614 PubMed 9135111 http://www.ncbi.nlm.nih.gov/pubmed/9135111 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000210111 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000210111 RefSeq YP_026221 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026221 STRING 511145.b4476 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4476&targetmode=cogs STRING COG2610 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2610&targetmode=cogs TCDB 2.A.8.1 http://www.tcdb.org/search/result.php?tc=2.A.8.1 TIGRFAMs TIGR00791 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00791 UniProtKB GNTU_ECOLI http://www.uniprot.org/uniprot/GNTU_ECOLI UniProtKB-AC P0AC96 http://www.uniprot.org/uniprot/P0AC96 charge swissprot:GNTU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GNTU_ECOLI eggNOG COG2610 http://eggnogapi.embl.de/nog_data/html/tree/COG2610 eggNOG ENOG4105C6Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C6Z epestfind swissprot:GNTU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GNTU_ECOLI garnier swissprot:GNTU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GNTU_ECOLI helixturnhelix swissprot:GNTU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GNTU_ECOLI hmoment swissprot:GNTU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GNTU_ECOLI iep swissprot:GNTU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GNTU_ECOLI inforesidue swissprot:GNTU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GNTU_ECOLI octanol swissprot:GNTU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GNTU_ECOLI pepcoil swissprot:GNTU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GNTU_ECOLI pepdigest swissprot:GNTU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GNTU_ECOLI pepinfo swissprot:GNTU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GNTU_ECOLI pepnet swissprot:GNTU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GNTU_ECOLI pepstats swissprot:GNTU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GNTU_ECOLI pepwheel swissprot:GNTU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GNTU_ECOLI pepwindow swissprot:GNTU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GNTU_ECOLI sigcleave swissprot:GNTU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GNTU_ECOLI ## Database ID URL or Descriptions # AltName ISPB_ECOLI All-trans-octaprenyl-diphosphate synthase # AltName ISPB_ECOLI Octaprenyl pyrophosphate synthase # BRENDA 2.5.1.90 2026 # BioGrid 4261111 123 # BioGrid 851687 2 # CATALYTIC ACTIVITY (2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-octaprenyl diphosphate. {ECO:0000269|PubMed 8037730}. # COFACTOR ISPB_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250}; Note=Binds 3 Mg(2+) ions per subunit. {ECO 0000250}; # EcoGene EG10017 ispB # FUNCTION ISPB_ECOLI Supplies octaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone and menaquinone. {ECO 0000269|PubMed 8037730}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004659 prenyltransferase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006744 ubiquinone biosynthetic process; IMP:EcoCyc. # GO_process GO:0016094 polyprenol biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 1.10.600.10 -; 1. # INTERACTION ISPB_ECOLI Self; NbExp=2; IntAct=EBI-1131851, EBI-1131851; O13851 dlp1 (xeno); NbExp=2; IntAct=EBI-1131851, EBI-7701234; O43091 dps1 (xeno); NbExp=2; IntAct=EBI-1131851, EBI-7701164; # IntAct P0AD57 5 # InterPro IPR000092 Polyprenyl_synt # InterPro IPR008949 Isoprenoid_synthase_dom # InterPro IPR033749 Polyprenyl_synt_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01006 Prenyltransferases # KEGG_Pathway ko00900 Terpenoid backbone biosynthesis # Organism ISPB_ECOLI Escherichia coli (strain K12) # PATRIC 32121794 VBIEscCol129921_3281 # PIR E65109 E65109 # PROSITE PS00444 POLYPRENYL_SYNTHASE_2 # PROSITE PS00723 POLYPRENYL_SYNTHASE_1 # Pfam PF00348 polyprenyl_synt # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ISPB_ECOLI Octaprenyl-diphosphate synthase # RefSeq NP_417654 NC_000913.3 # RefSeq WP_001047336 NZ_LN832404.1 # SIMILARITY Belongs to the FPP/GGPP synthase family. {ECO 0000305}. # SUPFAM SSF48576 SSF48576 # eggNOG COG0142 LUCA # eggNOG ENOG4105EAH Bacteria BLAST swissprot:ISPB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ISPB_ECOLI BioCyc ECOL316407:JW3154-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3154-MONOMER BioCyc EcoCyc:OPPSYN-MONOMER http://biocyc.org/getid?id=EcoCyc:OPPSYN-MONOMER BioCyc MetaCyc:OPPSYN-MONOMER http://biocyc.org/getid?id=MetaCyc:OPPSYN-MONOMER COG COG0142 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0142 DOI 10.1006/bbrc.1994.1933 http://dx.doi.org/10.1006/bbrc.1994.1933 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.5.1.90 http://www.genome.jp/dbget-bin/www_bget?EC:2.5.1.90 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D13267 http://www.ebi.ac.uk/ena/data/view/D13267 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X68873 http://www.ebi.ac.uk/ena/data/view/X68873 ENZYME 2.5.1.90 http://enzyme.expasy.org/EC/2.5.1.90 EchoBASE EB0017 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0017 EcoGene EG10017 http://www.ecogene.org/geneInfo.php?eg_id=EG10017 EnsemblBacteria AAC76219 http://www.ensemblgenomes.org/id/AAC76219 EnsemblBacteria AAC76219 http://www.ensemblgenomes.org/id/AAC76219 EnsemblBacteria BAE77231 http://www.ensemblgenomes.org/id/BAE77231 EnsemblBacteria BAE77231 http://www.ensemblgenomes.org/id/BAE77231 EnsemblBacteria BAE77231 http://www.ensemblgenomes.org/id/BAE77231 EnsemblBacteria b3187 http://www.ensemblgenomes.org/id/b3187 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004659 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004659 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006744 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006744 GO_process GO:0016094 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016094 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016765 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 1.10.600.10 http://www.cathdb.info/version/latest/superfamily/1.10.600.10 GeneID 947364 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947364 HOGENOM HOG000009102 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009102&db=HOGENOM6 InParanoid P0AD57 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AD57 IntAct P0AD57 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AD57* IntEnz 2.5.1.90 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.5.1.90 InterPro IPR000092 http://www.ebi.ac.uk/interpro/entry/IPR000092 InterPro IPR008949 http://www.ebi.ac.uk/interpro/entry/IPR008949 InterPro IPR033749 http://www.ebi.ac.uk/interpro/entry/IPR033749 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01006 http://www.genome.jp/dbget-bin/www_bget?ko01006 KEGG_Gene ecj:JW3154 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3154 KEGG_Gene eco:b3187 http://www.genome.jp/dbget-bin/www_bget?eco:b3187 KEGG_Orthology KO:K02523 http://www.genome.jp/dbget-bin/www_bget?KO:K02523 KEGG_Pathway ko00900 http://www.genome.jp/kegg-bin/show_pathway?ko00900 KEGG_Reaction rn:R09248 http://www.genome.jp/dbget-bin/www_bget?rn:R09248 MINT MINT-7384996 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-7384996 OMA MRVMEVL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MRVMEVL PROSITE PS00444 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00444 PROSITE PS00723 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00723 PSORT swissprot:ISPB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ISPB_ECOLI PSORT-B swissprot:ISPB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ISPB_ECOLI PSORT2 swissprot:ISPB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ISPB_ECOLI Pfam PF00348 http://pfam.xfam.org/family/PF00348 Phobius swissprot:ISPB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ISPB_ECOLI PhylomeDB P0AD57 http://phylomedb.org/?seqid=P0AD57 ProteinModelPortal P0AD57 http://www.proteinmodelportal.org/query/uniprot/P0AD57 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2670911 http://www.ncbi.nlm.nih.gov/pubmed/2670911 PubMed 8037730 http://www.ncbi.nlm.nih.gov/pubmed/8037730 PubMed 8312607 http://www.ncbi.nlm.nih.gov/pubmed/8312607 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417654 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417654 RefSeq WP_001047336 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001047336 SMR P0AD57 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AD57 STRING 511145.b3187 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3187&targetmode=cogs STRING COG0142 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0142&targetmode=cogs SUPFAM SSF48576 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48576 UniProtKB ISPB_ECOLI http://www.uniprot.org/uniprot/ISPB_ECOLI UniProtKB-AC P0AD57 http://www.uniprot.org/uniprot/P0AD57 charge swissprot:ISPB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ISPB_ECOLI eggNOG COG0142 http://eggnogapi.embl.de/nog_data/html/tree/COG0142 eggNOG ENOG4105EAH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EAH epestfind swissprot:ISPB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ISPB_ECOLI garnier swissprot:ISPB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ISPB_ECOLI helixturnhelix swissprot:ISPB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ISPB_ECOLI hmoment swissprot:ISPB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ISPB_ECOLI iep swissprot:ISPB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ISPB_ECOLI inforesidue swissprot:ISPB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ISPB_ECOLI octanol swissprot:ISPB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ISPB_ECOLI pepcoil swissprot:ISPB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ISPB_ECOLI pepdigest swissprot:ISPB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ISPB_ECOLI pepinfo swissprot:ISPB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ISPB_ECOLI pepnet swissprot:ISPB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ISPB_ECOLI pepstats swissprot:ISPB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ISPB_ECOLI pepwheel swissprot:ISPB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ISPB_ECOLI pepwindow swissprot:ISPB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ISPB_ECOLI sigcleave swissprot:ISPB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ISPB_ECOLI ## Database ID URL or Descriptions # BioGrid 4259939 126 # EcoGene EG13313 ybgQ # FUNCTION YBGQ_ECOLI Could be involved in the export and assembly of the putative YbgD fimbrial subunit across the outer membrane. # GO_component GO:0009279 cell outer membrane; IBA:GO_Central. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015473 fimbrial usher porin activity; IBA:GO_Central. # GO_process GO:0009297 pilus assembly; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0022607 cellular component assembly # InterPro IPR000015 Fimb_usher # InterPro IPR018030 Fimbrial_membr_usher_CS # InterPro IPR025885 PapC_N # InterPro IPR025949 PapC-like_C # Organism YBGQ_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30451 PTHR30451 # PATRIC 32116631 VBIEscCol129921_0748 # PIR E64807 E64807 # PROSITE PS01151 FIMBRIAL_USHER # Pfam PF00577 Usher # Pfam PF13953 PapC_C # Pfam PF13954 PapC_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBGQ_ECOLI Uncharacterized outer membrane usher protein YbgQ # RefSeq NP_415246 NC_000913.3 # RefSeq WP_001350492 NZ_LN832404.1 # SIMILARITY Belongs to the fimbrial export usher family. {ECO 0000305}. # SUBCELLULAR LOCATION YBGQ_ECOLI Cell outer membrane {ECO 0000250}; Multi- pass membrane protein {ECO 0000250}. # TCDB 1.B.11.2 the outer membrane fimbrial usher porin (fup) family # eggNOG COG3188 LUCA # eggNOG ENOG4106PG1 Bacteria BLAST swissprot:YBGQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBGQ_ECOLI BioCyc ECOL316407:JW5099-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5099-MONOMER BioCyc EcoCyc:G6387-MONOMER http://biocyc.org/getid?id=EcoCyc:G6387-MONOMER DIP DIP-11401N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11401N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3097 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3097 EcoGene EG13313 http://www.ecogene.org/geneInfo.php?eg_id=EG13313 EnsemblBacteria AAC73812 http://www.ensemblgenomes.org/id/AAC73812 EnsemblBacteria AAC73812 http://www.ensemblgenomes.org/id/AAC73812 EnsemblBacteria BAA35382 http://www.ensemblgenomes.org/id/BAA35382 EnsemblBacteria BAA35382 http://www.ensemblgenomes.org/id/BAA35382 EnsemblBacteria BAA35382 http://www.ensemblgenomes.org/id/BAA35382 EnsemblBacteria b0718 http://www.ensemblgenomes.org/id/b0718 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015473 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015473 GO_process GO:0009297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009297 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GeneID 946537 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946537 HOGENOM HOG000260138 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260138&db=HOGENOM6 InParanoid P75750 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75750 IntAct P75750 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75750* InterPro IPR000015 http://www.ebi.ac.uk/interpro/entry/IPR000015 InterPro IPR018030 http://www.ebi.ac.uk/interpro/entry/IPR018030 InterPro IPR025885 http://www.ebi.ac.uk/interpro/entry/IPR025885 InterPro IPR025949 http://www.ebi.ac.uk/interpro/entry/IPR025949 KEGG_Gene ecj:JW5099 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5099 KEGG_Gene eco:b0718 http://www.genome.jp/dbget-bin/www_bget?eco:b0718 MINT MINT-1307660 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1307660 OMA DERMLPW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DERMLPW PANTHER PTHR30451 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30451 PROSITE PS01151 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01151 PSORT swissprot:YBGQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBGQ_ECOLI PSORT-B swissprot:YBGQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBGQ_ECOLI PSORT2 swissprot:YBGQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBGQ_ECOLI Pfam PF00577 http://pfam.xfam.org/family/PF00577 Pfam PF13953 http://pfam.xfam.org/family/PF13953 Pfam PF13954 http://pfam.xfam.org/family/PF13954 Phobius swissprot:YBGQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBGQ_ECOLI PhylomeDB P75750 http://phylomedb.org/?seqid=P75750 ProteinModelPortal P75750 http://www.proteinmodelportal.org/query/uniprot/P75750 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415246 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415246 RefSeq WP_001350492 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001350492 SMR P75750 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75750 STRING 511145.b0718 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0718&targetmode=cogs TCDB 1.B.11.2 http://www.tcdb.org/search/result.php?tc=1.B.11.2 UniProtKB YBGQ_ECOLI http://www.uniprot.org/uniprot/YBGQ_ECOLI UniProtKB-AC P75750 http://www.uniprot.org/uniprot/P75750 charge swissprot:YBGQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBGQ_ECOLI eggNOG COG3188 http://eggnogapi.embl.de/nog_data/html/tree/COG3188 eggNOG ENOG4106PG1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106PG1 epestfind swissprot:YBGQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBGQ_ECOLI garnier swissprot:YBGQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBGQ_ECOLI helixturnhelix swissprot:YBGQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBGQ_ECOLI hmoment swissprot:YBGQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBGQ_ECOLI iep swissprot:YBGQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBGQ_ECOLI inforesidue swissprot:YBGQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBGQ_ECOLI octanol swissprot:YBGQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBGQ_ECOLI pepcoil swissprot:YBGQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBGQ_ECOLI pepdigest swissprot:YBGQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBGQ_ECOLI pepinfo swissprot:YBGQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBGQ_ECOLI pepnet swissprot:YBGQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBGQ_ECOLI pepstats swissprot:YBGQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBGQ_ECOLI pepwheel swissprot:YBGQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBGQ_ECOLI pepwindow swissprot:YBGQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBGQ_ECOLI sigcleave swissprot:YBGQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBGQ_ECOLI ## Database ID URL or Descriptions # AltName RECX_ECOLI Protein OraA # BioGrid 4259217 128 # EcoGene EG12080 recX # FUNCTION RECX_ECOLI Modulates RecA activity through direct physical interaction. Can inhibit both RecA recombinase and coprotease activities. May have a regulatory role during the SOS response. Inhibits DNA strand exchange in vitro. {ECO 0000269|PubMed 12427742}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0019899 enzyme binding; IPI:EcoCyc. # GO_process GO:0006281 DNA repair; IEA:UniProtKB-KW. # GO_process GO:0006282 regulation of DNA repair; IEA:UniProtKB-HAMAP. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoCyc. # GO_process GO:0009432 SOS response; IEP:EcoCyc. # GO_process GO:0043086 negative regulation of catalytic activity; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0019899 enzyme binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # Gene3D 1.10.10.10 -; 3. # HAMAP MF_01114 RecX # INDUCTION RECX_ECOLI By DNA damage, via LexA, as part of the SOS response. # INTERACTION RECX_ECOLI P61949 fldA; NbExp=3; IntAct=EBI-1129990, EBI-550021; # IntAct P33596 5 # InterPro IPR003783 Regulatory_RecX # InterPro IPR011991 WHTH_DNA-bd_dom # Organism RECX_ECOLI Escherichia coli (strain K12) # PATRIC 32120794 VBIEscCol129921_2789 # PDB 2A7Z Model; -; A=1-166 # PIR F65049 F65049 # Pfam PF02631 RecX # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RECX_ECOLI Regulatory protein RecX # RefSeq NP_417178 NC_000913.3 # RefSeq WP_000140508 NZ_LN832404.1 # SIMILARITY Belongs to the RecX family. {ECO 0000305}. # SUBCELLULAR LOCATION RECX_ECOLI Cytoplasm {ECO 0000305}. # eggNOG COG2137 LUCA # eggNOG ENOG4105Y3E Bacteria BLAST swissprot:RECX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RECX_ECOLI BioCyc ECOL316407:JW2668-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2668-MONOMER BioCyc EcoCyc:EG12080-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12080-MONOMER COG COG2137 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2137 DIP DIP-10410N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10410N DOI 10.1016/0165-7992(94)90030-2 http://dx.doi.org/10.1016/0165-7992(94)90030-2 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M210496200 http://dx.doi.org/10.1074/jbc.M210496200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/nar/22.7.1313 http://dx.doi.org/10.1093/nar/22.7.1313 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L25853 http://www.ebi.ac.uk/ena/data/view/L25853 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2005 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2005 EcoGene EG12080 http://www.ecogene.org/geneInfo.php?eg_id=EG12080 EnsemblBacteria AAC75740 http://www.ensemblgenomes.org/id/AAC75740 EnsemblBacteria AAC75740 http://www.ensemblgenomes.org/id/AAC75740 EnsemblBacteria BAA16560 http://www.ensemblgenomes.org/id/BAA16560 EnsemblBacteria BAA16560 http://www.ensemblgenomes.org/id/BAA16560 EnsemblBacteria BAA16560 http://www.ensemblgenomes.org/id/BAA16560 EnsemblBacteria b2698 http://www.ensemblgenomes.org/id/b2698 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0019899 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899 GO_process GO:0006281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006281 GO_process GO:0006282 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006282 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0009432 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009432 GO_process GO:0043086 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043086 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0019899 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 947172 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947172 HAMAP MF_01114 http://hamap.expasy.org/unirule/MF_01114 HOGENOM HOG000242561 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000242561&db=HOGENOM6 InParanoid P33596 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33596 IntAct P33596 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33596* InterPro IPR003783 http://www.ebi.ac.uk/interpro/entry/IPR003783 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW2668 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2668 KEGG_Gene eco:b2698 http://www.genome.jp/dbget-bin/www_bget?eco:b2698 KEGG_Orthology KO:K03565 http://www.genome.jp/dbget-bin/www_bget?KO:K03565 OMA VIAWCYE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VIAWCYE PDB 2A7Z http://www.ebi.ac.uk/pdbe-srv/view/entry/2A7Z PDBsum 2A7Z http://www.ebi.ac.uk/pdbsum/2A7Z PSORT swissprot:RECX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RECX_ECOLI PSORT-B swissprot:RECX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RECX_ECOLI PSORT2 swissprot:RECX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RECX_ECOLI Pfam PF02631 http://pfam.xfam.org/family/PF02631 Phobius swissprot:RECX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RECX_ECOLI PhylomeDB P33596 http://phylomedb.org/?seqid=P33596 ProteinModelPortal P33596 http://www.proteinmodelportal.org/query/uniprot/P33596 PubMed 12427742 http://www.ncbi.nlm.nih.gov/pubmed/12427742 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7512687 http://www.ncbi.nlm.nih.gov/pubmed/7512687 PubMed 8165147 http://www.ncbi.nlm.nih.gov/pubmed/8165147 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417178 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417178 RefSeq WP_000140508 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000140508 SMR P33596 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33596 STRING 511145.b2698 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2698&targetmode=cogs STRING COG2137 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2137&targetmode=cogs UniProtKB RECX_ECOLI http://www.uniprot.org/uniprot/RECX_ECOLI UniProtKB-AC P33596 http://www.uniprot.org/uniprot/P33596 charge swissprot:RECX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RECX_ECOLI eggNOG COG2137 http://eggnogapi.embl.de/nog_data/html/tree/COG2137 eggNOG ENOG4105Y3E http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105Y3E epestfind swissprot:RECX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RECX_ECOLI garnier swissprot:RECX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RECX_ECOLI helixturnhelix swissprot:RECX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RECX_ECOLI hmoment swissprot:RECX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RECX_ECOLI iep swissprot:RECX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RECX_ECOLI inforesidue swissprot:RECX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RECX_ECOLI octanol swissprot:RECX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RECX_ECOLI pepcoil swissprot:RECX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RECX_ECOLI pepdigest swissprot:RECX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RECX_ECOLI pepinfo swissprot:RECX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RECX_ECOLI pepnet swissprot:RECX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RECX_ECOLI pepstats swissprot:RECX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RECX_ECOLI pepwheel swissprot:RECX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RECX_ECOLI pepwindow swissprot:RECX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RECX_ECOLI sigcleave swissprot:RECX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RECX_ECOLI ## Database ID URL or Descriptions # AltName PDXH_ECOLI PNP/PMP oxidase # AltName PDXH_ECOLI Pyridoxal 5'-phosphate synthase # BIOPHYSICOCHEMICAL PROPERTIES PDXH_ECOLI Kinetic parameters KM=0.3 uM for pyridoxamine 5'-phosphate {ECO 0000269|PubMed 11786019}; KM=2 uM for pyridoxine 5'-phosphate (at pH 7.6 and 37 degrees Celsius) {ECO 0000269|PubMed 7860596, ECO 0000269|PubMed 9693059}; KM=105 uM for pyridoxamine 5'-phosphate (at pH 7.6 and 37 degrees Celsius) {ECO 0000269|PubMed 7860596}; Note=Kcat is 0.3 sec(-1) for oxidase activity with pyridoxine 5'-phosphate as substrate (at pH 7.6 and 37 degrees Celsius). {ECO 0000269|PubMed 9693059}; # BRENDA 1.4.3 2026 # CATALYTIC ACTIVITY PDXH_ECOLI Pyridoxamine 5'-phosphate + H(2)O + O(2) = pyridoxal 5'-phosphate + NH(3) + H(2)O(2). {ECO 0000269|PubMed 11786019, ECO 0000269|PubMed 7860596, ECO 0000269|PubMed 9693059}. # CATALYTIC ACTIVITY PDXH_ECOLI Pyridoxine 5'-phosphate + O(2) = pyridoxal 5'- phosphate + H(2)O(2). {ECO 0000269|PubMed 11786019, ECO 0000269|PubMed 7860596, ECO 0000269|PubMed 9693059}. # COFACTOR PDXH_ECOLI Name=FMN; Xref=ChEBI CHEBI 58210; Evidence={ECO 0000269|PubMed 10903950, ECO 0000269|PubMed 11453690, ECO 0000269|PubMed 11786019, ECO 0000269|PubMed 15858270, ECO 0000269|PubMed 7860596, ECO 0000269|PubMed 9693059}; Note=Binds 1 FMN per subunit. {ECO 0000269|PubMed 10903950, ECO 0000269|PubMed 11453690, ECO 0000269|PubMed 11786019, ECO 0000269|PubMed 15858270, ECO 0000269|PubMed 7860596, ECO 0000269|PubMed 9693059}; # EcoGene EG11487 pdxH # FUNCTION PDXH_ECOLI Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). {ECO 0000269|PubMed 11786019, ECO 0000269|PubMed 7860596, ECO 0000269|PubMed 9693059}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004733 pyridoxamine-phosphate oxidase activity; IDA:EcoCyc. # GO_function GO:0010181 FMN binding; IDA:EcoCyc. # GO_function GO:0016491 oxidoreductase activity; IDA:EcoliWiki. # GO_process GO:0008615 pyridoxine biosynthetic process; IDA:EcoCyc. # GO_process GO:0009443 pyridoxal 5'-phosphate salvage; EXP:EcoCyc. # GO_process GO:0055114 oxidation-reduction process; IDA:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 2.30.110.10 -; 1. # HAMAP MF_01629 PdxH # IntAct P0AFI7 13 # InterPro IPR000659 Pyridox_Oxase # InterPro IPR011576 Pyridox_Oxase_FMN-bd # InterPro IPR012349 Split_barrel_FMN-bd # InterPro IPR019576 Pyridoxamine_oxidase_dimer_C # InterPro IPR019740 Pyridox_Oxase_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00750 Vitamin B6 metabolism # MISCELLANEOUS PDXH_ECOLI Can bind a second molecule of pyridoxamine 5'- phosphate at a non-catalytic site in a cleft at the protein surface. # Organism PDXH_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10851:SF0 PTHR10851:SF0 # PATHWAY Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate step 1/1. # PATHWAY Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate step 1/1. # PATRIC 32118578 VBIEscCol129921_1709 # PDB 1DNL X-ray; 1.80 A; A=20-218 # PDB 1G76 X-ray; 2.20 A; A=1-218 # PDB 1G77 X-ray; 2.10 A; A=1-218 # PDB 1G78 X-ray; 2.20 A; A=1-218 # PDB 1G79 X-ray; 2.00 A; A=1-218 # PDB 1JNW X-ray; 2.07 A; A=1-218 # PDB 1WV4 X-ray; 2.60 A; A/B=1-218 # PIR B43261 B43261 # PIRSF PIRSF000190 Pyd_amn-ph_oxd # PROSITE PS01064 PYRIDOX_OXIDASE # Pfam PF01243 Pyridox_oxidase # Pfam PF10590 PNPOx_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PDXH_ECOLI Pyridoxine/pyridoxamine 5'-phosphate oxidase # RefSeq NP_416155 NC_000913.3 # RefSeq WP_001282319 NZ_LN832404.1 # SIMILARITY Belongs to the pyridoxamine 5'-phosphate oxidase family. {ECO 0000305}. # SUBUNIT PDXH_ECOLI Homodimer. {ECO 0000269|PubMed 10903950, ECO 0000269|PubMed 11453690, ECO 0000269|PubMed 11786019, ECO 0000269|PubMed 15858270, ECO 0000269|PubMed 7860596, ECO 0000269|PubMed 9693059}. # SUPFAM SSF50475 SSF50475 # TIGRFAMs TIGR00558 pdxH # UniPathway UPA01068 UER00304 # UniPathway UPA01068 UER00305 # eggNOG COG0259 LUCA # eggNOG ENOG4108S7T Bacteria BLAST swissprot:PDXH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PDXH_ECOLI BioCyc ECOL316407:JW1630-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1630-MONOMER BioCyc EcoCyc:PDXH-MONOMER http://biocyc.org/getid?id=EcoCyc:PDXH-MONOMER BioCyc MetaCyc:PDXH-MONOMER http://biocyc.org/getid?id=MetaCyc:PDXH-MONOMER COG COG0259 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0259 DIP DIP-48024N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48024N DOI 10.1006/jmbi.2001.4734 http://dx.doi.org/10.1006/jmbi.2001.4734 DOI 10.1006/jmbi.2001.5254 http://dx.doi.org/10.1006/jmbi.2001.5254 DOI 10.1006/prep.1998.0904 http://dx.doi.org/10.1006/prep.1998.0904 DOI 10.1016/S0969-2126(00)00162-3 http://dx.doi.org/10.1016/S0969-2126(00)00162-3 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1107/S0907444905005512 http://dx.doi.org/10.1107/S0907444905005512 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DisProt DP00165 http://www.disprot.org/protein.php?id=DP00165 EC_number EC:1.4.3.5 {ECO:0000269|PubMed:11786019, ECO:0000269|PubMed:7860596, ECO:0000269|PubMed:9693059} http://www.genome.jp/dbget-bin/www_bget?EC:1.4.3.5 {ECO:0000269|PubMed:11786019, ECO:0000269|PubMed:7860596, ECO:0000269|PubMed:9693059} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M92351 http://www.ebi.ac.uk/ena/data/view/M92351 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.4.3.5 {ECO:0000269|PubMed:11786019, ECO:0000269|PubMed:7860596, ECO:0000269|PubMed:9693059} http://enzyme.expasy.org/EC/1.4.3.5 {ECO:0000269|PubMed:11786019, ECO:0000269|PubMed:7860596, ECO:0000269|PubMed:9693059} EchoBASE EB1450 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1450 EcoGene EG11487 http://www.ecogene.org/geneInfo.php?eg_id=EG11487 EnsemblBacteria AAC74710 http://www.ensemblgenomes.org/id/AAC74710 EnsemblBacteria AAC74710 http://www.ensemblgenomes.org/id/AAC74710 EnsemblBacteria BAA15399 http://www.ensemblgenomes.org/id/BAA15399 EnsemblBacteria BAA15399 http://www.ensemblgenomes.org/id/BAA15399 EnsemblBacteria BAA15399 http://www.ensemblgenomes.org/id/BAA15399 EnsemblBacteria b1638 http://www.ensemblgenomes.org/id/b1638 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004733 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004733 GO_function GO:0010181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010181 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_process GO:0008615 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008615 GO_process GO:0009443 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009443 GO_process GO:0055114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 2.30.110.10 http://www.cathdb.info/version/latest/superfamily/2.30.110.10 GeneID 946806 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946806 HAMAP MF_01629 http://hamap.expasy.org/unirule/MF_01629 HOGENOM HOG000242755 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000242755&db=HOGENOM6 InParanoid P0AFI7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFI7 IntAct P0AFI7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFI7* IntEnz 1.4.3.5 {ECO:0000269|PubMed:11786019, ECO:0000269|PubMed:7860596, ECO:0000269|PubMed:9693059} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.4.3.5 {ECO:0000269|PubMed:11786019, ECO:0000269|PubMed:7860596, ECO:0000269|PubMed:9693059} InterPro IPR000659 http://www.ebi.ac.uk/interpro/entry/IPR000659 InterPro IPR011576 http://www.ebi.ac.uk/interpro/entry/IPR011576 InterPro IPR012349 http://www.ebi.ac.uk/interpro/entry/IPR012349 InterPro IPR019576 http://www.ebi.ac.uk/interpro/entry/IPR019576 InterPro IPR019740 http://www.ebi.ac.uk/interpro/entry/IPR019740 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1630 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1630 KEGG_Gene eco:b1638 http://www.genome.jp/dbget-bin/www_bget?eco:b1638 KEGG_Orthology KO:K00275 http://www.genome.jp/dbget-bin/www_bget?KO:K00275 KEGG_Pathway ko00750 http://www.genome.jp/kegg-bin/show_pathway?ko00750 KEGG_Reaction rn:R00277 http://www.genome.jp/dbget-bin/www_bget?rn:R00277 KEGG_Reaction rn:R00278 http://www.genome.jp/dbget-bin/www_bget?rn:R00278 KEGG_Reaction rn:R01710 http://www.genome.jp/dbget-bin/www_bget?rn:R01710 KEGG_Reaction rn:R01711 http://www.genome.jp/dbget-bin/www_bget?rn:R01711 OMA PEHWGGY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PEHWGGY PANTHER PTHR10851:SF0 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10851:SF0 PDB 1DNL http://www.ebi.ac.uk/pdbe-srv/view/entry/1DNL PDB 1G76 http://www.ebi.ac.uk/pdbe-srv/view/entry/1G76 PDB 1G77 http://www.ebi.ac.uk/pdbe-srv/view/entry/1G77 PDB 1G78 http://www.ebi.ac.uk/pdbe-srv/view/entry/1G78 PDB 1G79 http://www.ebi.ac.uk/pdbe-srv/view/entry/1G79 PDB 1JNW http://www.ebi.ac.uk/pdbe-srv/view/entry/1JNW PDB 1WV4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1WV4 PDBsum 1DNL http://www.ebi.ac.uk/pdbsum/1DNL PDBsum 1G76 http://www.ebi.ac.uk/pdbsum/1G76 PDBsum 1G77 http://www.ebi.ac.uk/pdbsum/1G77 PDBsum 1G78 http://www.ebi.ac.uk/pdbsum/1G78 PDBsum 1G79 http://www.ebi.ac.uk/pdbsum/1G79 PDBsum 1JNW http://www.ebi.ac.uk/pdbsum/1JNW PDBsum 1WV4 http://www.ebi.ac.uk/pdbsum/1WV4 PROSITE PS01064 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01064 PSORT swissprot:PDXH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PDXH_ECOLI PSORT-B swissprot:PDXH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PDXH_ECOLI PSORT2 swissprot:PDXH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PDXH_ECOLI Pfam PF01243 http://pfam.xfam.org/family/PF01243 Pfam PF10590 http://pfam.xfam.org/family/PF10590 Phobius swissprot:PDXH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PDXH_ECOLI PhylomeDB P0AFI7 http://phylomedb.org/?seqid=P0AFI7 ProteinModelPortal P0AFI7 http://www.proteinmodelportal.org/query/uniprot/P0AFI7 PubMed 10903950 http://www.ncbi.nlm.nih.gov/pubmed/10903950 PubMed 11453690 http://www.ncbi.nlm.nih.gov/pubmed/11453690 PubMed 11786019 http://www.ncbi.nlm.nih.gov/pubmed/11786019 PubMed 1356963 http://www.ncbi.nlm.nih.gov/pubmed/1356963 PubMed 15858270 http://www.ncbi.nlm.nih.gov/pubmed/15858270 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7860596 http://www.ncbi.nlm.nih.gov/pubmed/7860596 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9693059 http://www.ncbi.nlm.nih.gov/pubmed/9693059 RefSeq NP_416155 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416155 RefSeq WP_001282319 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001282319 SMR P0AFI7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFI7 STRING 511145.b1638 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1638&targetmode=cogs STRING COG0259 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0259&targetmode=cogs SUPFAM SSF50475 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50475 TIGRFAMs TIGR00558 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00558 UniProtKB PDXH_ECOLI http://www.uniprot.org/uniprot/PDXH_ECOLI UniProtKB-AC P0AFI7 http://www.uniprot.org/uniprot/P0AFI7 charge swissprot:PDXH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PDXH_ECOLI eggNOG COG0259 http://eggnogapi.embl.de/nog_data/html/tree/COG0259 eggNOG ENOG4108S7T http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108S7T epestfind swissprot:PDXH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PDXH_ECOLI garnier swissprot:PDXH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PDXH_ECOLI helixturnhelix swissprot:PDXH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PDXH_ECOLI hmoment swissprot:PDXH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PDXH_ECOLI iep swissprot:PDXH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PDXH_ECOLI inforesidue swissprot:PDXH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PDXH_ECOLI octanol swissprot:PDXH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PDXH_ECOLI pepcoil swissprot:PDXH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PDXH_ECOLI pepdigest swissprot:PDXH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PDXH_ECOLI pepinfo swissprot:PDXH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PDXH_ECOLI pepnet swissprot:PDXH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PDXH_ECOLI pepstats swissprot:PDXH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PDXH_ECOLI pepwheel swissprot:PDXH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PDXH_ECOLI pepwindow swissprot:PDXH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PDXH_ECOLI sigcleave swissprot:PDXH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PDXH_ECOLI ## Database ID URL or Descriptions # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG40121 insO # GO_process GO:0032196 transposition; IEA:UniProtKB-KW. # GOslim_process GO:0032196 transposition # INTERACTION INSO1_ECOLI P75728 ubiF; NbExp=3; IntAct=EBI-9152908, EBI-562588; P37909 ybgD; NbExp=2; IntAct=EBI-9152908, EBI-1119998; # IntAct P75680 8 # Organism INSO1_ECOLI Escherichia coli (strain K12) # PATRIC 48659712 VBIEscCol107702_0252 # PIR A64751 A64751 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSO1_ECOLI Putative transposase InsO for insertion sequence element IS911A # RefSeq WP_000212151 NZ_LN832404.1 # eggNOG COG2801 LUCA BLAST swissprot:INSO1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSO1_ECOLI BioCyc ECOL316407:JW0247-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0247-MONOMER BioCyc EcoCyc:G6132-MONOMER http://biocyc.org/getid?id=EcoCyc:G6132-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG40121 http://www.ecogene.org/geneInfo.php?eg_id=EG40121 EnsemblBacteria BAA77926 http://www.ensemblgenomes.org/id/BAA77926 EnsemblBacteria BAA77926 http://www.ensemblgenomes.org/id/BAA77926 EnsemblBacteria BAA77926 http://www.ensemblgenomes.org/id/BAA77926 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 InParanoid P75680 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75680 IntAct P75680 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75680* KEGG_Gene ecj:JW0247 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0247 OMA QENAGHT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QENAGHT PSORT swissprot:INSO1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSO1_ECOLI PSORT-B swissprot:INSO1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSO1_ECOLI PSORT2 swissprot:INSO1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSO1_ECOLI Phobius swissprot:INSO1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSO1_ECOLI PhylomeDB P75680 http://phylomedb.org/?seqid=P75680 ProteinModelPortal P75680 http://www.proteinmodelportal.org/query/uniprot/P75680 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000212151 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000212151 SMR P75680 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75680 STRING 316407.85674401 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85674401&targetmode=cogs UniProtKB INSO1_ECOLI http://www.uniprot.org/uniprot/INSO1_ECOLI UniProtKB-AC P75680 http://www.uniprot.org/uniprot/P75680 charge swissprot:INSO1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSO1_ECOLI eggNOG COG2801 http://eggnogapi.embl.de/nog_data/html/tree/COG2801 epestfind swissprot:INSO1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSO1_ECOLI garnier swissprot:INSO1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSO1_ECOLI helixturnhelix swissprot:INSO1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSO1_ECOLI hmoment swissprot:INSO1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSO1_ECOLI iep swissprot:INSO1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSO1_ECOLI inforesidue swissprot:INSO1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSO1_ECOLI octanol swissprot:INSO1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSO1_ECOLI pepcoil swissprot:INSO1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSO1_ECOLI pepdigest swissprot:INSO1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSO1_ECOLI pepinfo swissprot:INSO1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSO1_ECOLI pepnet swissprot:INSO1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSO1_ECOLI pepstats swissprot:INSO1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSO1_ECOLI pepwheel swissprot:INSO1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSO1_ECOLI pepwindow swissprot:INSO1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSO1_ECOLI sigcleave swissprot:INSO1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSO1_ECOLI ## Database ID URL or Descriptions # BioGrid 4260683 6 # EcoGene EG12133 ucpA # GO_function GO:0016491 oxidoreductase activity; IEA:UniProtKB-KW. # GOslim_function GO:0016491 oxidoreductase activity # Gene3D 3.40.50.720 -; 1. # IntAct P37440 3 # InterPro IPR002347 SDR_fam # InterPro IPR016040 NAD(P)-bd_dom # Organism UCPA_ECOLI Escherichia coli (strain K12) # PATRIC 32120237 VBIEscCol129921_2521 # PIR A65017 A65017 # PRINTS PR00080 SDRFAMILY # PRINTS PR00081 GDHRDH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UCPA_ECOLI Oxidoreductase UcpA # RefSeq NP_416921 NC_000913.3 # RefSeq WP_000517431 NZ_LN832404.1 # SIMILARITY Belongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO 0000305}. # SUPFAM SSF51735 SSF51735 # eggNOG ENOG4105I7Z Bacteria # eggNOG ENOG410XSIT LUCA BLAST swissprot:UCPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UCPA_ECOLI BioCyc ECOL316407:JW5394-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5394-MONOMER BioCyc EcoCyc:EG12133-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12133-MONOMER DIP DIP-11073N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11073N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M32101 http://www.ebi.ac.uk/ena/data/view/M32101 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X99908 http://www.ebi.ac.uk/ena/data/view/X99908 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- EchoBASE EB2054 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2054 EcoGene EG12133 http://www.ecogene.org/geneInfo.php?eg_id=EG12133 EnsemblBacteria AAC75479 http://www.ensemblgenomes.org/id/AAC75479 EnsemblBacteria AAC75479 http://www.ensemblgenomes.org/id/AAC75479 EnsemblBacteria BAA16309 http://www.ensemblgenomes.org/id/BAA16309 EnsemblBacteria BAA16309 http://www.ensemblgenomes.org/id/BAA16309 EnsemblBacteria BAA16309 http://www.ensemblgenomes.org/id/BAA16309 EnsemblBacteria b2426 http://www.ensemblgenomes.org/id/b2426 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 946898 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946898 InParanoid P37440 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37440 IntAct P37440 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37440* IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR002347 http://www.ebi.ac.uk/interpro/entry/IPR002347 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 KEGG_Gene ecj:JW5394 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5394 KEGG_Gene eco:b2426 http://www.genome.jp/dbget-bin/www_bget?eco:b2426 MINT MINT-1256783 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1256783 OMA ILYFQRE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ILYFQRE PRINTS PR00080 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00080 PRINTS PR00081 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00081 PSORT swissprot:UCPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UCPA_ECOLI PSORT-B swissprot:UCPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UCPA_ECOLI PSORT2 swissprot:UCPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UCPA_ECOLI Phobius swissprot:UCPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UCPA_ECOLI PhylomeDB P37440 http://phylomedb.org/?seqid=P37440 ProteinModelPortal P37440 http://www.proteinmodelportal.org/query/uniprot/P37440 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2188959 http://www.ncbi.nlm.nih.gov/pubmed/2188959 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9241368 http://www.ncbi.nlm.nih.gov/pubmed/9241368 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416921 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416921 RefSeq WP_000517431 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000517431 SMR P37440 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37440 STRING 511145.b2426 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2426&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB UCPA_ECOLI http://www.uniprot.org/uniprot/UCPA_ECOLI UniProtKB-AC P37440 http://www.uniprot.org/uniprot/P37440 charge swissprot:UCPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UCPA_ECOLI eggNOG ENOG4105I7Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105I7Z eggNOG ENOG410XSIT http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XSIT epestfind swissprot:UCPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UCPA_ECOLI garnier swissprot:UCPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UCPA_ECOLI helixturnhelix swissprot:UCPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UCPA_ECOLI hmoment swissprot:UCPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UCPA_ECOLI iep swissprot:UCPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UCPA_ECOLI inforesidue swissprot:UCPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UCPA_ECOLI octanol swissprot:UCPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UCPA_ECOLI pepcoil swissprot:UCPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UCPA_ECOLI pepdigest swissprot:UCPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UCPA_ECOLI pepinfo swissprot:UCPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UCPA_ECOLI pepnet swissprot:UCPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UCPA_ECOLI pepstats swissprot:UCPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UCPA_ECOLI pepwheel swissprot:UCPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UCPA_ECOLI pepwindow swissprot:UCPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UCPA_ECOLI sigcleave swissprot:UCPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UCPA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262038 7 # COFACTOR Name=FMN; Xref=ChEBI:CHEBI 58210; Evidence={ECO:0000250}; # EcoGene EG13779 yddH # GO_function GO:0010181 FMN binding; IEA:InterPro. # GO_function GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor; IBA:GO_Central. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # Gene3D 2.30.110.10 -; 1. # IntAct P76121 13 # InterPro IPR002563 Flavin_Rdtase-like_dom # InterPro IPR012349 Split_barrel_FMN-bd # Organism YDDH_ECOLI Escherichia coli (strain K12) # PATRIC 32118216 VBIEscCol129921_1528 # PIR A64899 A64899 # Pfam PF01613 Flavin_Reduct # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDDH_ECOLI Uncharacterized protein YddH # RefSeq NP_415979 NC_000913.3 # RefSeq WP_000085899 NZ_LN832404.1 # SIMILARITY Belongs to the flavoredoxin family. {ECO 0000305}. # SMART SM00903 Flavin_Reduct # SUPFAM SSF50475 SSF50475 # eggNOG COG1853 LUCA # eggNOG ENOG4108MEJ Bacteria BLAST swissprot:YDDH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDDH_ECOLI BioCyc ECOL316407:JW1457-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1457-MONOMER BioCyc EcoCyc:G6769-MONOMER http://biocyc.org/getid?id=EcoCyc:G6769-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3541 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3541 EcoGene EG13779 http://www.ecogene.org/geneInfo.php?eg_id=EG13779 EnsemblBacteria AAC74544 http://www.ensemblgenomes.org/id/AAC74544 EnsemblBacteria AAC74544 http://www.ensemblgenomes.org/id/AAC74544 EnsemblBacteria BAE76448 http://www.ensemblgenomes.org/id/BAE76448 EnsemblBacteria BAE76448 http://www.ensemblgenomes.org/id/BAE76448 EnsemblBacteria BAE76448 http://www.ensemblgenomes.org/id/BAE76448 EnsemblBacteria b1462 http://www.ensemblgenomes.org/id/b1462 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0010181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010181 GO_function GO:0016646 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016646 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 2.30.110.10 http://www.cathdb.info/version/latest/superfamily/2.30.110.10 GeneID 946192 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946192 HOGENOM HOG000115782 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000115782&db=HOGENOM6 InParanoid P76121 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76121 IntAct P76121 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76121* InterPro IPR002563 http://www.ebi.ac.uk/interpro/entry/IPR002563 InterPro IPR012349 http://www.ebi.ac.uk/interpro/entry/IPR012349 KEGG_Gene ecj:JW1457 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1457 KEGG_Gene eco:b1462 http://www.genome.jp/dbget-bin/www_bget?eco:b1462 OMA WAMPLDF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WAMPLDF PSORT swissprot:YDDH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDDH_ECOLI PSORT-B swissprot:YDDH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDDH_ECOLI PSORT2 swissprot:YDDH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDDH_ECOLI Pfam PF01613 http://pfam.xfam.org/family/PF01613 Phobius swissprot:YDDH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDDH_ECOLI PhylomeDB P76121 http://phylomedb.org/?seqid=P76121 ProteinModelPortal P76121 http://www.proteinmodelportal.org/query/uniprot/P76121 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415979 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415979 RefSeq WP_000085899 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000085899 SMART SM00903 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00903 SMR P76121 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76121 STRING 511145.b1462 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1462&targetmode=cogs SUPFAM SSF50475 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50475 UniProtKB YDDH_ECOLI http://www.uniprot.org/uniprot/YDDH_ECOLI UniProtKB-AC P76121 http://www.uniprot.org/uniprot/P76121 charge swissprot:YDDH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDDH_ECOLI eggNOG COG1853 http://eggnogapi.embl.de/nog_data/html/tree/COG1853 eggNOG ENOG4108MEJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MEJ epestfind swissprot:YDDH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDDH_ECOLI garnier swissprot:YDDH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDDH_ECOLI helixturnhelix swissprot:YDDH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDDH_ECOLI hmoment swissprot:YDDH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDDH_ECOLI iep swissprot:YDDH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDDH_ECOLI inforesidue swissprot:YDDH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDDH_ECOLI octanol swissprot:YDDH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDDH_ECOLI pepcoil swissprot:YDDH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDDH_ECOLI pepdigest swissprot:YDDH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDDH_ECOLI pepinfo swissprot:YDDH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDDH_ECOLI pepnet swissprot:YDDH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDDH_ECOLI pepstats swissprot:YDDH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDDH_ECOLI pepwheel swissprot:YDDH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDDH_ECOLI pepwindow swissprot:YDDH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDDH_ECOLI sigcleave swissprot:YDDH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDDH_ECOLI ## Database ID URL or Descriptions # BRENDA 4.1.1.31 2026 # BioGrid 4262649 8 # CATALYTIC ACTIVITY CAPP_ECOLI Phosphate + oxaloacetate = H(2)O + phosphoenolpyruvate + HCO(3)(-). # COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI 18420; Evidence={ECO:0000250}; # ENZYME REGULATION CAPP_ECOLI The enzyme has distinct binding sites for each of the allosteric effectors such as acetyl-CoA, fructose 1,6- bisphosphate, guanosine 3'-diphosphate 5'-diphosphate, long chain fatty acids, and L-aspartate. # EcoGene EG10756 ppc # FUNCTION CAPP_ECOLI Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008964 phosphoenolpyruvate carboxylase activity; IDA:EcoCyc. # GO_process GO:0006099 tricarboxylic acid cycle; IEA:InterPro. # GO_process GO:0006107 oxaloacetate metabolic process; IEA:UniProtKB-HAMAP. # GO_process GO:0015977 carbon fixation; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0044281 small molecule metabolic process # HAMAP MF_00595 PEPcase_type1 # IntAct P00864 3 # InterPro IPR015813 Pyrv/PenolPyrv_Kinase-like_dom # InterPro IPR018129 PEP_COase_Lys_AS # InterPro IPR021135 PEP_COase # InterPro IPR022805 PEP_COase_bac/pln-type # InterPro IPR033129 PEPCASE_His_AS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00620 Pyruvate metabolism # KEGG_Pathway ko00680 Methane metabolism # KEGG_Pathway ko00710 Carbon fixation in photosynthetic organisms # KEGG_Pathway ko00720 Carbon fixation pathways in prokaryotes # Organism CAPP_ECOLI Escherichia coli (strain K12) # PATRIC 32123433 VBIEscCol129921_4077 # PDB 1FIY X-ray; 2.80 A; A=1-883 # PDB 1JQN X-ray; 2.35 A; A=1-883 # PDB 1QB4 X-ray; 2.60 A; A=1-883 # PIR A01083 QYEC # PRINTS PR00150 PEPCARBXLASE # PROSITE PS00393 PEPCASE_2 # PROSITE PS00781 PEPCASE_1 # Pfam PF00311 PEPcase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CAPP_ECOLI Phosphoenolpyruvate carboxylase # RefSeq NP_418391 NC_000913.3 # RefSeq WP_001005586 NZ_LN832404.1 # SIMILARITY Belongs to the PEPCase type 1 family. {ECO 0000305}. # SUBUNIT CAPP_ECOLI Homotetramer. # SUPFAM SSF51621 SSF51621 # WEB RESOURCE CAPP_ECOLI Name=Worthington enzyme manual; URL="http //www.worthington-biochem.com/PEPC/"; # eggNOG COG2352 LUCA # eggNOG ENOG4105CCA Bacteria BLAST swissprot:CAPP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CAPP_ECOLI BioCyc ECOL316407:JW3928-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3928-MONOMER BioCyc EcoCyc:PEPCARBOX-MONOMER http://biocyc.org/getid?id=EcoCyc:PEPCARBOX-MONOMER BioCyc MetaCyc:PEPCARBOX-MONOMER http://biocyc.org/getid?id=MetaCyc:PEPCARBOX-MONOMER COG COG1892 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1892 COG COG2352 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2352 DIP DIP-10538N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10538N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0022-2836(89)90515-9 http://dx.doi.org/10.1016/0022-2836(89)90515-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.96.3.823 http://dx.doi.org/10.1073/pnas.96.3.823 DOI 10.1093/nar/13.1.59 http://dx.doi.org/10.1093/nar/13.1.59 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1111/j.1432-1033.1991.tb16435.x http://dx.doi.org/10.1111/j.1432-1033.1991.tb16435.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.1.1.31 http://www.genome.jp/dbget-bin/www_bget?EC:4.1.1.31 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X01700 http://www.ebi.ac.uk/ena/data/view/X01700 EMBL X05903 http://www.ebi.ac.uk/ena/data/view/X05903 EMBL X55417 http://www.ebi.ac.uk/ena/data/view/X55417 ENZYME 4.1.1.31 http://enzyme.expasy.org/EC/4.1.1.31 EchoBASE EB0749 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0749 EcoGene EG10756 http://www.ecogene.org/geneInfo.php?eg_id=EG10756 EnsemblBacteria AAC76938 http://www.ensemblgenomes.org/id/AAC76938 EnsemblBacteria AAC76938 http://www.ensemblgenomes.org/id/AAC76938 EnsemblBacteria BAE77355 http://www.ensemblgenomes.org/id/BAE77355 EnsemblBacteria BAE77355 http://www.ensemblgenomes.org/id/BAE77355 EnsemblBacteria BAE77355 http://www.ensemblgenomes.org/id/BAE77355 EnsemblBacteria b3956 http://www.ensemblgenomes.org/id/b3956 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0008964 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008964 GO_process GO:0006099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006099 GO_process GO:0006107 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006107 GO_process GO:0015977 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015977 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 948457 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948457 HAMAP MF_00595 http://hamap.expasy.org/unirule/MF_00595 HOGENOM HOG000238648 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000238648&db=HOGENOM6 InParanoid P00864 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00864 IntAct P00864 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00864* IntEnz 4.1.1.31 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.1.31 InterPro IPR015813 http://www.ebi.ac.uk/interpro/entry/IPR015813 InterPro IPR018129 http://www.ebi.ac.uk/interpro/entry/IPR018129 InterPro IPR021135 http://www.ebi.ac.uk/interpro/entry/IPR021135 InterPro IPR022805 http://www.ebi.ac.uk/interpro/entry/IPR022805 InterPro IPR033129 http://www.ebi.ac.uk/interpro/entry/IPR033129 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3928 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3928 KEGG_Gene eco:b3956 http://www.genome.jp/dbget-bin/www_bget?eco:b3956 KEGG_Orthology KO:K01595 http://www.genome.jp/dbget-bin/www_bget?KO:K01595 KEGG_Pathway ko00620 http://www.genome.jp/kegg-bin/show_pathway?ko00620 KEGG_Pathway ko00680 http://www.genome.jp/kegg-bin/show_pathway?ko00680 KEGG_Pathway ko00710 http://www.genome.jp/kegg-bin/show_pathway?ko00710 KEGG_Pathway ko00720 http://www.genome.jp/kegg-bin/show_pathway?ko00720 KEGG_Reaction rn:R00345 http://www.genome.jp/dbget-bin/www_bget?rn:R00345 OMA IAEAWHT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IAEAWHT PDB 1FIY http://www.ebi.ac.uk/pdbe-srv/view/entry/1FIY PDB 1JQN http://www.ebi.ac.uk/pdbe-srv/view/entry/1JQN PDB 1QB4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1QB4 PDBsum 1FIY http://www.ebi.ac.uk/pdbsum/1FIY PDBsum 1JQN http://www.ebi.ac.uk/pdbsum/1JQN PDBsum 1QB4 http://www.ebi.ac.uk/pdbsum/1QB4 PRINTS PR00150 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00150 PROSITE PS00393 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00393 PROSITE PS00781 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00781 PSORT swissprot:CAPP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CAPP_ECOLI PSORT-B swissprot:CAPP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CAPP_ECOLI PSORT2 swissprot:CAPP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CAPP_ECOLI Pfam PF00311 http://pfam.xfam.org/family/PF00311 Phobius swissprot:CAPP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CAPP_ECOLI PhylomeDB P00864 http://phylomedb.org/?seqid=P00864 ProteinModelPortal P00864 http://www.proteinmodelportal.org/query/uniprot/P00864 PubMed 1551850 http://www.ncbi.nlm.nih.gov/pubmed/1551850 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1765093 http://www.ncbi.nlm.nih.gov/pubmed/1765093 PubMed 2016273 http://www.ncbi.nlm.nih.gov/pubmed/2016273 PubMed 2677392 http://www.ncbi.nlm.nih.gov/pubmed/2677392 PubMed 3889833 http://www.ncbi.nlm.nih.gov/pubmed/3889833 PubMed 6086598 http://www.ncbi.nlm.nih.gov/pubmed/6086598 PubMed 7490260 http://www.ncbi.nlm.nih.gov/pubmed/7490260 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9927652 http://www.ncbi.nlm.nih.gov/pubmed/9927652 RefSeq NP_418391 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418391 RefSeq WP_001005586 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001005586 SMR P00864 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00864 STRING 511145.b3956 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3956&targetmode=cogs STRING COG1892 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1892&targetmode=cogs STRING COG2352 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2352&targetmode=cogs SUPFAM SSF51621 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51621 UniProtKB CAPP_ECOLI http://www.uniprot.org/uniprot/CAPP_ECOLI UniProtKB-AC P00864 http://www.uniprot.org/uniprot/P00864 charge swissprot:CAPP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CAPP_ECOLI eggNOG COG2352 http://eggnogapi.embl.de/nog_data/html/tree/COG2352 eggNOG ENOG4105CCA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CCA epestfind swissprot:CAPP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CAPP_ECOLI garnier swissprot:CAPP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CAPP_ECOLI helixturnhelix swissprot:CAPP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CAPP_ECOLI hmoment swissprot:CAPP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CAPP_ECOLI iep swissprot:CAPP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CAPP_ECOLI inforesidue swissprot:CAPP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CAPP_ECOLI octanol swissprot:CAPP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CAPP_ECOLI pepcoil swissprot:CAPP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CAPP_ECOLI pepdigest swissprot:CAPP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CAPP_ECOLI pepinfo swissprot:CAPP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CAPP_ECOLI pepnet swissprot:CAPP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CAPP_ECOLI pepstats swissprot:CAPP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CAPP_ECOLI pepwheel swissprot:CAPP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CAPP_ECOLI pepwindow swissprot:CAPP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CAPP_ECOLI sigcleave swissprot:CAPP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CAPP_ECOLI ## Database ID URL or Descriptions # BioGrid 4263022 300 # EcoGene EG13749 ynbB # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0004605 phosphatidate cytidylyltransferase activity; IBA:GO_Central. # GO_process GO:0006655 phosphatidylglycerol biosynthetic process; IBA:GO_Central. # GO_process GO:0009273 peptidoglycan-based cell wall biogenesis; IMP:EcoCyc. # GO_process GO:0016024 CDP-diacylglycerol biosynthetic process; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0071554 cell wall organization or biogenesis # InterPro IPR000374 PC_trans # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00564 Glycerophospholipid metabolism # KEGG_Pathway ko04070 Phosphatidylinositol signaling system # Organism YNBB_ECOLI Escherichia coli (strain K12) # PATRIC 32118104 VBIEscCol129921_1472 # PIR D64892 D64892 # PROSITE PS01315 CDS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNBB_ECOLI Uncharacterized protein YnbB # RefSeq NP_415927 NC_000913.3 # RefSeq WP_000890941 NZ_LN832404.1 # SIMILARITY Belongs to the CDS family. {ECO 0000305}. # SUBCELLULAR LOCATION YNBB_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # eggNOG COG4589 LUCA # eggNOG ENOG4108HPI Bacteria BLAST swissprot:YNBB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNBB_ECOLI BioCyc ECOL316407:JW1406-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1406-MONOMER BioCyc EcoCyc:G6728-MONOMER http://biocyc.org/getid?id=EcoCyc:G6728-MONOMER COG COG0575 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0575 DIP DIP-12743N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12743N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3512 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3512 EcoGene EG13749 http://www.ecogene.org/geneInfo.php?eg_id=EG13749 EnsemblBacteria AAC74491 http://www.ensemblgenomes.org/id/AAC74491 EnsemblBacteria AAC74491 http://www.ensemblgenomes.org/id/AAC74491 EnsemblBacteria BAA15023 http://www.ensemblgenomes.org/id/BAA15023 EnsemblBacteria BAA15023 http://www.ensemblgenomes.org/id/BAA15023 EnsemblBacteria BAA15023 http://www.ensemblgenomes.org/id/BAA15023 EnsemblBacteria b1409 http://www.ensemblgenomes.org/id/b1409 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0004605 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004605 GO_process GO:0006655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006655 GO_process GO:0009273 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009273 GO_process GO:0016024 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016024 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 GeneID 945972 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945972 HOGENOM HOG000259010 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000259010&db=HOGENOM6 InParanoid P76091 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76091 IntAct P76091 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76091* InterPro IPR000374 http://www.ebi.ac.uk/interpro/entry/IPR000374 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1406 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1406 KEGG_Gene eco:b1409 http://www.genome.jp/dbget-bin/www_bget?eco:b1409 KEGG_Orthology KO:K00981 http://www.genome.jp/dbget-bin/www_bget?KO:K00981 KEGG_Pathway ko00564 http://www.genome.jp/kegg-bin/show_pathway?ko00564 KEGG_Pathway ko04070 http://www.genome.jp/kegg-bin/show_pathway?ko04070 KEGG_Reaction rn:R01799 http://www.genome.jp/dbget-bin/www_bget?rn:R01799 OMA CISHVPA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CISHVPA PROSITE PS01315 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01315 PSORT swissprot:YNBB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNBB_ECOLI PSORT-B swissprot:YNBB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNBB_ECOLI PSORT2 swissprot:YNBB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNBB_ECOLI Phobius swissprot:YNBB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNBB_ECOLI PhylomeDB P76091 http://phylomedb.org/?seqid=P76091 ProteinModelPortal P76091 http://www.proteinmodelportal.org/query/uniprot/P76091 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415927 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415927 RefSeq WP_000890941 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000890941 STRING 511145.b1409 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1409&targetmode=cogs STRING COG0575 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0575&targetmode=cogs UniProtKB YNBB_ECOLI http://www.uniprot.org/uniprot/YNBB_ECOLI UniProtKB-AC P76091 http://www.uniprot.org/uniprot/P76091 charge swissprot:YNBB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNBB_ECOLI eggNOG COG4589 http://eggnogapi.embl.de/nog_data/html/tree/COG4589 eggNOG ENOG4108HPI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108HPI epestfind swissprot:YNBB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNBB_ECOLI garnier swissprot:YNBB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNBB_ECOLI helixturnhelix swissprot:YNBB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNBB_ECOLI hmoment swissprot:YNBB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNBB_ECOLI iep swissprot:YNBB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNBB_ECOLI inforesidue swissprot:YNBB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNBB_ECOLI octanol swissprot:YNBB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNBB_ECOLI pepcoil swissprot:YNBB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNBB_ECOLI pepdigest swissprot:YNBB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNBB_ECOLI pepinfo swissprot:YNBB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNBB_ECOLI pepnet swissprot:YNBB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNBB_ECOLI pepstats swissprot:YNBB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNBB_ECOLI pepwheel swissprot:YNBB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNBB_ECOLI pepwindow swissprot:YNBB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNBB_ECOLI sigcleave swissprot:YNBB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNBB_ECOLI ## Database ID URL or Descriptions # BioGrid 4262666 8 # EcoGene EG11930 yjbL # InterPro IPR020276 Uncharacterised_YjbL # Organism YJBL_ECOLI Escherichia coli (strain K12) # PATRIC 32123631 VBIEscCol129921_4164 # PIR F65212 F65212 # ProDom PD060861 Uncharacterised_YjbL_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJBL_ECOLI Uncharacterized protein YjbL # RefSeq NP_418471 NC_000913.3 # RefSeq WP_000912571 NZ_LN832404.1 BLAST swissprot:YJBL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJBL_ECOLI BioCyc ECOL316407:JW4007-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4007-MONOMER BioCyc EcoCyc:EG11930-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11930-MONOMER DIP DIP-12540N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12540N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1874 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1874 EcoGene EG11930 http://www.ecogene.org/geneInfo.php?eg_id=EG11930 EnsemblBacteria AAC77017 http://www.ensemblgenomes.org/id/AAC77017 EnsemblBacteria AAC77017 http://www.ensemblgenomes.org/id/AAC77017 EnsemblBacteria BAE78049 http://www.ensemblgenomes.org/id/BAE78049 EnsemblBacteria BAE78049 http://www.ensemblgenomes.org/id/BAE78049 EnsemblBacteria BAE78049 http://www.ensemblgenomes.org/id/BAE78049 EnsemblBacteria b4047 http://www.ensemblgenomes.org/id/b4047 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 948551 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948551 HOGENOM HOG000009807 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009807&db=HOGENOM6 IntAct P32693 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32693* InterPro IPR020276 http://www.ebi.ac.uk/interpro/entry/IPR020276 KEGG_Gene ecj:JW4007 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4007 KEGG_Gene eco:b4047 http://www.genome.jp/dbget-bin/www_bget?eco:b4047 OMA ITKIDLF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ITKIDLF PSORT swissprot:YJBL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJBL_ECOLI PSORT-B swissprot:YJBL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJBL_ECOLI PSORT2 swissprot:YJBL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJBL_ECOLI Phobius swissprot:YJBL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJBL_ECOLI ProteinModelPortal P32693 http://www.proteinmodelportal.org/query/uniprot/P32693 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418471 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418471 RefSeq WP_000912571 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000912571 STRING 511145.b4047 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4047&targetmode=cogs UniProtKB YJBL_ECOLI http://www.uniprot.org/uniprot/YJBL_ECOLI UniProtKB-AC P32693 http://www.uniprot.org/uniprot/P32693 charge swissprot:YJBL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJBL_ECOLI epestfind swissprot:YJBL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJBL_ECOLI garnier swissprot:YJBL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJBL_ECOLI helixturnhelix swissprot:YJBL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJBL_ECOLI hmoment swissprot:YJBL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJBL_ECOLI iep swissprot:YJBL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJBL_ECOLI inforesidue swissprot:YJBL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJBL_ECOLI octanol swissprot:YJBL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJBL_ECOLI pepcoil swissprot:YJBL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJBL_ECOLI pepdigest swissprot:YJBL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJBL_ECOLI pepinfo swissprot:YJBL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJBL_ECOLI pepnet swissprot:YJBL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJBL_ECOLI pepstats swissprot:YJBL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJBL_ECOLI pepwheel swissprot:YJBL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJBL_ECOLI pepwindow swissprot:YJBL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJBL_ECOLI sigcleave swissprot:YJBL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJBL_ECOLI ## Database ID URL or Descriptions # AltName ASLA_ECOLI Aryl-sulfate sulphohydrolase # BioGrid 4262605 5 # CATALYTIC ACTIVITY ASLA_ECOLI A phenol sulfate + H(2)O = a phenol + sulfate. # COFACTOR ASLA_ECOLI Name=Ca(2+); Xref=ChEBI CHEBI 29108; Evidence={ECO 0000250}; Note=Binds 1 Ca(2+) ion per subunit. {ECO 0000250}; # EcoGene EG10089 aslA # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_function GO:0004065 arylsulfatase activity; IEA:UniProtKB-EC. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0008152 metabolic process; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # Gene3D 3.40.720.10 -; 1. # InterPro IPR000917 Sulfatase_N # InterPro IPR017849 Alkaline_Pase-like_a/b/a # InterPro IPR017850 Alkaline_phosphatase_core # InterPro IPR024607 Sulfatase_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00140 Steroid hormone biosynthesis # KEGG_Pathway ko00600 Sphingolipid metabolism # Organism ASLA_ECOLI Escherichia coli (strain K12) # PATRIC 32123099 VBIEscCol129921_3915 # PIR S30691 S30691 # PROSITE PS00149 SULFATASE_2 # PROSITE PS00523 SULFATASE_1 # PTM ASLA_ECOLI The conversion to 3-oxoalanine (also known as C- formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. {ECO 0000250}. # Pfam PF00884 Sulfatase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ASLA_ECOLI Arylsulfatase # RefSeq NP_418245 NC_000913.3 # RefSeq WP_000395863 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAC32036.1; Type=Frameshift; Positions=462; Evidence={ECO 0000305}; # SIMILARITY Belongs to the sulfatase family. {ECO 0000305}. # SUBCELLULAR LOCATION ASLA_ECOLI Periplasm {ECO 0000305}. # SUPFAM SSF53649 SSF53649 # eggNOG COG3119 LUCA # eggNOG ENOG4105ENH Bacteria BLAST swissprot:ASLA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ASLA_ECOLI BioCyc ECOL316407:JW3773-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3773-MONOMER BioCyc EcoCyc:ARYLSULFAT-MONOMER http://biocyc.org/getid?id=EcoCyc:ARYLSULFAT-MONOMER BioCyc MetaCyc:ARYLSULFAT-MONOMER http://biocyc.org/getid?id=MetaCyc:ARYLSULFAT-MONOMER COG COG3119 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3119 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.6.1 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.6.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL M90498 http://www.ebi.ac.uk/ena/data/view/M90498 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.6.1 http://enzyme.expasy.org/EC/3.1.6.1 EchoBASE EB0087 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0087 EcoGene EG10089 http://www.ecogene.org/geneInfo.php?eg_id=EG10089 EnsemblBacteria AAC76804 http://www.ensemblgenomes.org/id/AAC76804 EnsemblBacteria AAC76804 http://www.ensemblgenomes.org/id/AAC76804 EnsemblBacteria BAE77500 http://www.ensemblgenomes.org/id/BAE77500 EnsemblBacteria BAE77500 http://www.ensemblgenomes.org/id/BAE77500 EnsemblBacteria BAE77500 http://www.ensemblgenomes.org/id/BAE77500 EnsemblBacteria b3801 http://www.ensemblgenomes.org/id/b3801 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0004065 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004065 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0008152 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008152 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.720.10 http://www.cathdb.info/version/latest/superfamily/3.40.720.10 GeneID 949015 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949015 HOGENOM HOG000126460 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126460&db=HOGENOM6 InParanoid P25549 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P25549 IntAct P25549 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P25549* IntEnz 3.1.6.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.6.1 InterPro IPR000917 http://www.ebi.ac.uk/interpro/entry/IPR000917 InterPro IPR017849 http://www.ebi.ac.uk/interpro/entry/IPR017849 InterPro IPR017850 http://www.ebi.ac.uk/interpro/entry/IPR017850 InterPro IPR024607 http://www.ebi.ac.uk/interpro/entry/IPR024607 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3773 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3773 KEGG_Gene eco:b3801 http://www.genome.jp/dbget-bin/www_bget?eco:b3801 KEGG_Orthology KO:K01130 http://www.genome.jp/dbget-bin/www_bget?KO:K01130 KEGG_Pathway ko00140 http://www.genome.jp/kegg-bin/show_pathway?ko00140 KEGG_Pathway ko00600 http://www.genome.jp/kegg-bin/show_pathway?ko00600 KEGG_Reaction rn:R03980 http://www.genome.jp/dbget-bin/www_bget?rn:R03980 KEGG_Reaction rn:R04856 http://www.genome.jp/dbget-bin/www_bget?rn:R04856 OMA VHHDPPL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VHHDPPL PROSITE PS00149 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00149 PROSITE PS00523 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00523 PSORT swissprot:ASLA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ASLA_ECOLI PSORT-B swissprot:ASLA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ASLA_ECOLI PSORT2 swissprot:ASLA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ASLA_ECOLI Pfam PF00884 http://pfam.xfam.org/family/PF00884 Phobius swissprot:ASLA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ASLA_ECOLI PhylomeDB P25549 http://phylomedb.org/?seqid=P25549 ProteinModelPortal P25549 http://www.proteinmodelportal.org/query/uniprot/P25549 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418245 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418245 RefSeq WP_000395863 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000395863 STRING 511145.b3801 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3801&targetmode=cogs STRING COG3119 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3119&targetmode=cogs SUPFAM SSF53649 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53649 UniProtKB ASLA_ECOLI http://www.uniprot.org/uniprot/ASLA_ECOLI UniProtKB-AC P25549 http://www.uniprot.org/uniprot/P25549 charge swissprot:ASLA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ASLA_ECOLI eggNOG COG3119 http://eggnogapi.embl.de/nog_data/html/tree/COG3119 eggNOG ENOG4105ENH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ENH epestfind swissprot:ASLA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ASLA_ECOLI garnier swissprot:ASLA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ASLA_ECOLI helixturnhelix swissprot:ASLA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ASLA_ECOLI hmoment swissprot:ASLA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ASLA_ECOLI iep swissprot:ASLA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ASLA_ECOLI inforesidue swissprot:ASLA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ASLA_ECOLI octanol swissprot:ASLA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ASLA_ECOLI pepcoil swissprot:ASLA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ASLA_ECOLI pepdigest swissprot:ASLA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ASLA_ECOLI pepinfo swissprot:ASLA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ASLA_ECOLI pepnet swissprot:ASLA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ASLA_ECOLI pepstats swissprot:ASLA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ASLA_ECOLI pepwheel swissprot:ASLA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ASLA_ECOLI pepwindow swissprot:ASLA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ASLA_ECOLI sigcleave swissprot:ASLA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ASLA_ECOLI ## Database ID URL or Descriptions # AltName KDGK_ECOLI 2-keto-3-deoxygluconokinase # AltName KDGK_ECOLI 3-deoxy-2-oxo-D-gluconate kinase # AltName KDGK_ECOLI KDG kinase # BIOPHYSICOCHEMICAL PROPERTIES KDGK_ECOLI Kinetic parameters KM=1 uM for ATP {ECO 0000269|PubMed 4944816}; KM=1 uM for KDG {ECO 0000269|PubMed 4944816}; pH dependence Optimum pH is around 6. {ECO 0000269|PubMed 4944816}; # BioGrid 4262528 7 # CATALYTIC ACTIVITY ATP + 2-dehydro-3-deoxy-D-gluconate = ADP + 2- dehydro-3-deoxy-6-phospho-D-gluconate. {ECO:0000269|PubMed 4944816}. # EcoGene EG12253 kdgK # FUNCTION KDGK_ECOLI Catalyzes the phosphorylation of 2-keto-3-deoxygluconate (KDG) to produce 2-keto-3-deoxy-6-phosphogluconate (KDPG). {ECO 0000269|PubMed 4944816}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0008673 2-dehydro-3-deoxygluconokinase activity; IDA:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0019698 D-galacturonate catabolic process; IMP:EcoCyc. # GO_process GO:0042840 D-glucuronate catabolic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.1190.20 -; 1. # IntAct P37647 3 # InterPro IPR002173 Carboh/pur_kinase_PfkB_CS # InterPro IPR011611 PfkB_dom # InterPro IPR029056 Ribokinase-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00030 Pentose phosphate pathway # KEGG_Pathway ko00040 Pentose and glucuronate interconversions # Organism KDGK_ECOLI Escherichia coli (strain K12) # PATHWAY Carbohydrate acid metabolism; 2-dehydro-3-deoxy-D- gluconate degradation; D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-gluconate step 1/2. # PATRIC 32122516 VBIEscCol129921_3636 # PIR S47747 S47747 # PROSITE PS00584 PFKB_KINASES_2 # Pfam PF00294 PfkB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName KDGK_ECOLI 2-dehydro-3-deoxygluconokinase # RefSeq NP_417983 NC_000913.3 # RefSeq WP_000037562 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18503.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the carbohydrate kinase PfkB family. {ECO 0000305}. # SUPFAM SSF53613 SSF53613 # UniPathway UPA00856 UER00828 # eggNOG COG0524 LUCA # eggNOG ENOG4107SS6 Bacteria BLAST swissprot:KDGK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:KDGK_ECOLI BioCyc ECOL316407:JW5668-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5668-MONOMER BioCyc EcoCyc:DEOXYGLUCONOKIN-MONOMER http://biocyc.org/getid?id=EcoCyc:DEOXYGLUCONOKIN-MONOMER BioCyc MetaCyc:DEOXYGLUCONOKIN-MONOMER http://biocyc.org/getid?id=MetaCyc:DEOXYGLUCONOKIN-MONOMER COG COG0524 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0524 DIP DIP-10056N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10056N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.45 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.45 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.45 http://enzyme.expasy.org/EC/2.7.1.45 EchoBASE EB2163 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2163 EcoGene EG12253 http://www.ecogene.org/geneInfo.php?eg_id=EG12253 EnsemblBacteria AAC76551 http://www.ensemblgenomes.org/id/AAC76551 EnsemblBacteria AAC76551 http://www.ensemblgenomes.org/id/AAC76551 EnsemblBacteria BAE77768 http://www.ensemblgenomes.org/id/BAE77768 EnsemblBacteria BAE77768 http://www.ensemblgenomes.org/id/BAE77768 EnsemblBacteria BAE77768 http://www.ensemblgenomes.org/id/BAE77768 EnsemblBacteria b3526 http://www.ensemblgenomes.org/id/b3526 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008673 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008673 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0019698 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019698 GO_process GO:0042840 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042840 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.1190.20 http://www.cathdb.info/version/latest/superfamily/3.40.1190.20 GeneID 948041 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948041 HOGENOM HOG000235952 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000235952&db=HOGENOM6 InParanoid P37647 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37647 IntAct P37647 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37647* IntEnz 2.7.1.45 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.45 InterPro IPR002173 http://www.ebi.ac.uk/interpro/entry/IPR002173 InterPro IPR011611 http://www.ebi.ac.uk/interpro/entry/IPR011611 InterPro IPR029056 http://www.ebi.ac.uk/interpro/entry/IPR029056 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5668 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5668 KEGG_Gene eco:b3526 http://www.genome.jp/dbget-bin/www_bget?eco:b3526 KEGG_Orthology KO:K00874 http://www.genome.jp/dbget-bin/www_bget?KO:K00874 KEGG_Pathway ko00030 http://www.genome.jp/kegg-bin/show_pathway?ko00030 KEGG_Pathway ko00040 http://www.genome.jp/kegg-bin/show_pathway?ko00040 KEGG_Reaction rn:R01541 http://www.genome.jp/dbget-bin/www_bget?rn:R01541 MINT MINT-1219186 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1219186 OMA RGAESCL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RGAESCL PROSITE PS00584 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00584 PSORT swissprot:KDGK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:KDGK_ECOLI PSORT-B swissprot:KDGK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:KDGK_ECOLI PSORT2 swissprot:KDGK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:KDGK_ECOLI Pfam PF00294 http://pfam.xfam.org/family/PF00294 Phobius swissprot:KDGK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:KDGK_ECOLI PhylomeDB P37647 http://phylomedb.org/?seqid=P37647 ProteinModelPortal P37647 http://www.proteinmodelportal.org/query/uniprot/P37647 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 4944816 http://www.ncbi.nlm.nih.gov/pubmed/4944816 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417983 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417983 RefSeq WP_000037562 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000037562 SMR P37647 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37647 STRING 511145.b3526 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3526&targetmode=cogs STRING COG0524 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0524&targetmode=cogs SUPFAM SSF53613 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53613 UniProtKB KDGK_ECOLI http://www.uniprot.org/uniprot/KDGK_ECOLI UniProtKB-AC P37647 http://www.uniprot.org/uniprot/P37647 charge swissprot:KDGK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:KDGK_ECOLI eggNOG COG0524 http://eggnogapi.embl.de/nog_data/html/tree/COG0524 eggNOG ENOG4107SS6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107SS6 epestfind swissprot:KDGK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:KDGK_ECOLI garnier swissprot:KDGK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:KDGK_ECOLI helixturnhelix swissprot:KDGK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:KDGK_ECOLI hmoment swissprot:KDGK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:KDGK_ECOLI iep swissprot:KDGK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:KDGK_ECOLI inforesidue swissprot:KDGK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:KDGK_ECOLI octanol swissprot:KDGK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:KDGK_ECOLI pepcoil swissprot:KDGK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:KDGK_ECOLI pepdigest swissprot:KDGK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:KDGK_ECOLI pepinfo swissprot:KDGK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:KDGK_ECOLI pepnet swissprot:KDGK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:KDGK_ECOLI pepstats swissprot:KDGK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:KDGK_ECOLI pepwheel swissprot:KDGK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:KDGK_ECOLI pepwindow swissprot:KDGK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:KDGK_ECOLI sigcleave swissprot:KDGK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:KDGK_ECOLI ## Database ID URL or Descriptions # AltName EIIC-Gat {ECO:0000303|PubMed 7772602} # AltName Galactitol permease IIC component {ECO:0000303|PubMed 7772602} # BioGrid 4260430 3 # CAUTION A pseudogene in strain MG1655 / ATCC 700926 due to a recent laboratory-derived single nucleotide insertion, but not its parent MG1655 / ATCC 47076. {ECO:0000305|PubMed 22081388}. # DOMAIN PTKC_ECOLI The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site. {ECO 0000255|PROSITE-ProRule PRU00427}. # EcoGene EG12416 gatC # FUNCTION PTKC_ECOLI The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. The enzyme II complex composed of GatA, GatB and GatC is involved in galactitol transport. {ECO 0000269|PubMed 8955298}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015577 galactitol transmembrane transporter activity; IEA:InterPro. # GO_function GO:0090584 protein-phosphocysteine-galactitol-phosphotransferase system transporter activity; IDA:EcoCyc. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IDA:EcoCyc. # GO_process GO:0015796 galactitol transport; IDA:EcoCyc. # GO_process GO:0019402 galactitol metabolic process; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006810 transport # GOslim_process GO:0044281 small molecule metabolic process # INDUCTION Constitutively expressed. {ECO:0000269|PubMed 8955298}. # InterPro IPR004703 PTS_sugar-sp_permease # InterPro IPR013014 PTS_EIIC_2 # InterPro IPR013853 GatC # Organism PTKC_ECOLI Escherichia coli (strain K12) # PATRIC 32119517 VBIEscCol129921_2169 # PIR C64976 C64976 # PIR S55905 S55905 # PIRSF PIRSF006304 GatC # PROSITE PS51104 PTS_EIIC_TYPE_2 # Pfam PF03611 EIIC-GAT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PTS system galactitol-specific EIIC component {ECO:0000303|PubMed 7772602} # RefSeq WP_000490679 NZ_LN832404.1 # SIMILARITY Contains 1 PTS EIIC type-2 domain. {ECO:0000255|PROSITE-ProRule PRU00427}. # SUBCELLULAR LOCATION PTKC_ECOLI Cell inner membrane {ECO 0000255|PROSITE- ProRule PRU00427, ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 16079137}; Multi-pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00427, ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 16079137}. # SUBUNIT Forms a complex with one each of subunit of GatA, GatB and 2 subunits of GatC. {ECO:0000269|PubMed 16079137}. # TCDB 4.A.5.1 the pts galactitol (gat) family # TIGRFAMs TIGR00827 EIIC-GAT # eggNOG COG3775 LUCA # eggNOG ENOG4105DT3 Bacteria BLAST swissprot:PTKC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTKC_ECOLI BioCyc ECOL316407:JW2076-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2076-MONOMER BioCyc EcoCyc:GATC-MONOMER http://biocyc.org/getid?id=EcoCyc:GATC-MONOMER BioCyc MetaCyc:GATC-MONOMER http://biocyc.org/getid?id=MetaCyc:GATC-MONOMER DOI 10.1016/0167-4781(95)00053-J http://dx.doi.org/10.1016/0167-4781(95)00053-J DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.06087-11 http://dx.doi.org/10.1128/JB.06087-11 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X79837 http://www.ebi.ac.uk/ena/data/view/X79837 EchoBASE EB2315 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2315 EcoGene EG12416 http://www.ecogene.org/geneInfo.php?eg_id=EG12416 EnsemblBacteria BAA15955 http://www.ensemblgenomes.org/id/BAA15955 EnsemblBacteria BAA15955 http://www.ensemblgenomes.org/id/BAA15955 EnsemblBacteria BAA15955 http://www.ensemblgenomes.org/id/BAA15955 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015577 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015577 GO_function GO:0090584 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090584 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GO_process GO:0015796 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015796 GO_process GO:0019402 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019402 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 HOGENOM HOG000053574 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000053574&db=HOGENOM6 InParanoid P69831 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P69831 InterPro IPR004703 http://www.ebi.ac.uk/interpro/entry/IPR004703 InterPro IPR013014 http://www.ebi.ac.uk/interpro/entry/IPR013014 InterPro IPR013853 http://www.ebi.ac.uk/interpro/entry/IPR013853 KEGG_Gene ecj:JW2076 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2076 OMA GFYVANA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GFYVANA PROSITE PS51104 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51104 PSORT swissprot:PTKC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTKC_ECOLI PSORT-B swissprot:PTKC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTKC_ECOLI PSORT2 swissprot:PTKC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTKC_ECOLI Pfam PF03611 http://pfam.xfam.org/family/PF03611 Phobius swissprot:PTKC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTKC_ECOLI PhylomeDB P69831 http://phylomedb.org/?seqid=P69831 ProteinModelPortal P69831 http://www.proteinmodelportal.org/query/uniprot/P69831 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22081388 http://www.ncbi.nlm.nih.gov/pubmed/22081388 PubMed 7772602 http://www.ncbi.nlm.nih.gov/pubmed/7772602 PubMed 8955298 http://www.ncbi.nlm.nih.gov/pubmed/8955298 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000490679 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000490679 STRING 511145.b2092 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2092&targetmode=cogs TCDB 4.A.5.1 http://www.tcdb.org/search/result.php?tc=4.A.5.1 TIGRFAMs TIGR00827 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00827 UniProtKB PTKC_ECOLI http://www.uniprot.org/uniprot/PTKC_ECOLI UniProtKB-AC P69831 http://www.uniprot.org/uniprot/P69831 charge swissprot:PTKC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTKC_ECOLI eggNOG COG3775 http://eggnogapi.embl.de/nog_data/html/tree/COG3775 eggNOG ENOG4105DT3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DT3 epestfind swissprot:PTKC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTKC_ECOLI garnier swissprot:PTKC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTKC_ECOLI helixturnhelix swissprot:PTKC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTKC_ECOLI hmoment swissprot:PTKC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTKC_ECOLI iep swissprot:PTKC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTKC_ECOLI inforesidue swissprot:PTKC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTKC_ECOLI octanol swissprot:PTKC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTKC_ECOLI pepcoil swissprot:PTKC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTKC_ECOLI pepdigest swissprot:PTKC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTKC_ECOLI pepinfo swissprot:PTKC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTKC_ECOLI pepnet swissprot:PTKC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTKC_ECOLI pepstats swissprot:PTKC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTKC_ECOLI pepwheel swissprot:PTKC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTKC_ECOLI pepwindow swissprot:PTKC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTKC_ECOLI sigcleave swissprot:PTKC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTKC_ECOLI ## Database ID URL or Descriptions # BioGrid 4260818 21 # EcoGene EG13840 ynfB # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # HAMAP MF_01581 UPF0482 # IntAct P76170 3 # InterPro IPR009700 DUF1283 # Organism YNFB_ECOLI Escherichia coli (strain K12) # PATRIC 32118468 VBIEscCol129921_1654 # PIR A64914 A64914 # Pfam PF06932 DUF1283 # ProDom PD073251 DUF1283 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UPF0482 protein YnfB {ECO:0000255|HAMAP-Rule MF_01581} # RefSeq NP_416100 NC_000913.3 # RefSeq WP_000705211 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0482 family. {ECO:0000255|HAMAP- Rule MF_01581}. # eggNOG ENOG4105M5Q Bacteria # eggNOG ENOG4111VZ1 LUCA BLAST swissprot:YNFB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNFB_ECOLI BioCyc ECOL316407:JW1575-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1575-MONOMER BioCyc EcoCyc:G6841-MONOMER http://biocyc.org/getid?id=EcoCyc:G6841-MONOMER DIP DIP-12762N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12762N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3601 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3601 EcoGene EG13840 http://www.ecogene.org/geneInfo.php?eg_id=EG13840 EnsemblBacteria AAC74655 http://www.ensemblgenomes.org/id/AAC74655 EnsemblBacteria AAC74655 http://www.ensemblgenomes.org/id/AAC74655 EnsemblBacteria BAE76477 http://www.ensemblgenomes.org/id/BAE76477 EnsemblBacteria BAE76477 http://www.ensemblgenomes.org/id/BAE76477 EnsemblBacteria BAE76477 http://www.ensemblgenomes.org/id/BAE76477 EnsemblBacteria b1583 http://www.ensemblgenomes.org/id/b1583 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GeneID 946119 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946119 HAMAP MF_01581 http://hamap.expasy.org/unirule/MF_01581 HOGENOM HOG000059285 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000059285&db=HOGENOM6 IntAct P76170 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76170* InterPro IPR009700 http://www.ebi.ac.uk/interpro/entry/IPR009700 KEGG_Gene ecj:JW1575 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1575 KEGG_Gene eco:b1583 http://www.genome.jp/dbget-bin/www_bget?eco:b1583 OMA DKEQWND http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DKEQWND PSORT swissprot:YNFB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNFB_ECOLI PSORT-B swissprot:YNFB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNFB_ECOLI PSORT2 swissprot:YNFB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNFB_ECOLI Pfam PF06932 http://pfam.xfam.org/family/PF06932 Phobius swissprot:YNFB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNFB_ECOLI ProteinModelPortal P76170 http://www.proteinmodelportal.org/query/uniprot/P76170 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416100 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416100 RefSeq WP_000705211 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000705211 STRING 511145.b1583 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1583&targetmode=cogs UniProtKB YNFB_ECOLI http://www.uniprot.org/uniprot/YNFB_ECOLI UniProtKB-AC P76170 http://www.uniprot.org/uniprot/P76170 charge swissprot:YNFB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNFB_ECOLI eggNOG ENOG4105M5Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105M5Q eggNOG ENOG4111VZ1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111VZ1 epestfind swissprot:YNFB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNFB_ECOLI garnier swissprot:YNFB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNFB_ECOLI helixturnhelix swissprot:YNFB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNFB_ECOLI hmoment swissprot:YNFB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNFB_ECOLI iep swissprot:YNFB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNFB_ECOLI inforesidue swissprot:YNFB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNFB_ECOLI octanol swissprot:YNFB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNFB_ECOLI pepcoil swissprot:YNFB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNFB_ECOLI pepdigest swissprot:YNFB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNFB_ECOLI pepinfo swissprot:YNFB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNFB_ECOLI pepnet swissprot:YNFB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNFB_ECOLI pepstats swissprot:YNFB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNFB_ECOLI pepwheel swissprot:YNFB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNFB_ECOLI pepwindow swissprot:YNFB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNFB_ECOLI sigcleave swissprot:YNFB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNFB_ECOLI ## Database ID URL or Descriptions # AltName VSR_ECOLI DNA mismatch endonuclease # AltName VSR_ECOLI V.EcoKDcm # AltName VSR_ECOLI Vsr mismatch endonuclease # BioGrid 4263264 75 # CDD cd00221 Vsr # COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI 18420; Note=Binds 2 magnesium ions per subunit.; # COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI 29105; Note=Binds 1 zinc ion per subunit.; # EcoGene EG11068 vsr # FUNCTION VSR_ECOLI Deamination of 5-methylcytosine in DNA results in T/G mismatches. If unrepaired, these mismatches can lead to C-to-C transition mutations. The very short patch (VSP) repair process in E.coli counteracts the mutagenic process by repairing the mismatches in favor of the G-containing strand. This enzyme is an endonuclease that nicks double-stranded DNA within the sequence CT(AT)GN or NT(AT)GG next to the thymidine residue that is mismatched to 2'-deoxyguanosine. The incision is mismatch- dependent and strand-specific. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0043765 T/G mismatch-specific endonuclease activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006298 mismatch repair; IDA:EcoCyc. # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004518 nuclease activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # Gene3D 3.40.960.10 -; 1. # INTERACTION VSR_ECOLI P23367 mutL; NbExp=3; IntAct=EBI-765033, EBI-554913; # IntAct P09184 10 # InterPro IPR004603 DNA_mismatch_endonuc_vsr # InterPro IPR011335 Restrct_endonuc-II-like # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # Organism VSR_ECOLI Escherichia coli (strain K12) # PATRIC 32119249 VBIEscCol129921_2039 # PDB 1CW0 X-ray; 2.30 A; A=2-156 # PDB 1ODG X-ray; 2.80 A; A=23-156 # PDB 1VSR X-ray; 1.80 A; A=21-156 # PIR JS0264 JS0264 # PIRSF PIRSF018267 VSR_endonuc # Pfam PF03852 Vsr # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # REBASE 3641 V.EcoKDcm # RecName VSR_ECOLI Very short patch repair protein # RefSeq NP_416469 NC_000913.3 # RefSeq WP_000786005 NZ_LN832404.1 # SIMILARITY Belongs to the vsr family. {ECO 0000305}. # SUPFAM SSF52980 SSF52980 # TIGRFAMs TIGR00632 vsr # eggNOG COG3727 LUCA # eggNOG ENOG41090BB Bacteria BLAST swissprot:VSR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:VSR_ECOLI BioCyc ECOL316407:JW1943-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1943-MONOMER BioCyc EcoCyc:EG11068-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11068-MONOMER COG COG3727 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3727 DIP DIP-11114N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11114N DOI 10.1016/S0092-8674(00)81550-0 http://dx.doi.org/10.1016/S0092-8674(00)81550-0 DOI 10.1016/S1097-2765(00)80355-X http://dx.doi.org/10.1016/S1097-2765(00)80355-X DOI 10.1038/353776a0 http://dx.doi.org/10.1038/353776a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/nar/17.14.5844 http://dx.doi.org/10.1093/nar/17.14.5844 DOI 10.1093/nar/28.13.2535 http://dx.doi.org/10.1093/nar/28.13.2535 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M32307 http://www.ebi.ac.uk/ena/data/view/M32307 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X13330 http://www.ebi.ac.uk/ena/data/view/X13330 ENZYME 3.1.-.- http://enzyme.expasy.org/EC/3.1.-.- EchoBASE EB1061 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1061 EcoGene EG11068 http://www.ecogene.org/geneInfo.php?eg_id=EG11068 EnsemblBacteria AAC75026 http://www.ensemblgenomes.org/id/AAC75026 EnsemblBacteria AAC75026 http://www.ensemblgenomes.org/id/AAC75026 EnsemblBacteria BAA15787 http://www.ensemblgenomes.org/id/BAA15787 EnsemblBacteria BAA15787 http://www.ensemblgenomes.org/id/BAA15787 EnsemblBacteria BAA15787 http://www.ensemblgenomes.org/id/BAA15787 EnsemblBacteria b1960 http://www.ensemblgenomes.org/id/b1960 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0043765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043765 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006298 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006298 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.40.960.10 http://www.cathdb.info/version/latest/superfamily/3.40.960.10 GeneID 946476 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946476 HOGENOM HOG000239922 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000239922&db=HOGENOM6 InParanoid P09184 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P09184 IntAct P09184 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P09184* IntEnz 3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1 InterPro IPR004603 http://www.ebi.ac.uk/interpro/entry/IPR004603 InterPro IPR011335 http://www.ebi.ac.uk/interpro/entry/IPR011335 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW1943 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1943 KEGG_Gene eco:b1960 http://www.genome.jp/dbget-bin/www_bget?eco:b1960 KEGG_Orthology KO:K07458 http://www.genome.jp/dbget-bin/www_bget?KO:K07458 OMA HDCYLFK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HDCYLFK PDB 1CW0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1CW0 PDB 1ODG http://www.ebi.ac.uk/pdbe-srv/view/entry/1ODG PDB 1VSR http://www.ebi.ac.uk/pdbe-srv/view/entry/1VSR PDBsum 1CW0 http://www.ebi.ac.uk/pdbsum/1CW0 PDBsum 1ODG http://www.ebi.ac.uk/pdbsum/1ODG PDBsum 1VSR http://www.ebi.ac.uk/pdbsum/1VSR PSORT swissprot:VSR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:VSR_ECOLI PSORT-B swissprot:VSR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:VSR_ECOLI PSORT2 swissprot:VSR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:VSR_ECOLI Pfam PF03852 http://pfam.xfam.org/family/PF03852 Phobius swissprot:VSR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:VSR_ECOLI PhylomeDB P09184 http://phylomedb.org/?seqid=P09184 ProteinModelPortal P09184 http://www.proteinmodelportal.org/query/uniprot/P09184 PubMed 10360178 http://www.ncbi.nlm.nih.gov/pubmed/10360178 PubMed 10612397 http://www.ncbi.nlm.nih.gov/pubmed/10612397 PubMed 10871403 http://www.ncbi.nlm.nih.gov/pubmed/10871403 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1944537 http://www.ncbi.nlm.nih.gov/pubmed/1944537 PubMed 2198248 http://www.ncbi.nlm.nih.gov/pubmed/2198248 PubMed 2527357 http://www.ncbi.nlm.nih.gov/pubmed/2527357 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 REBASE 3641 http://rebase.neb.com/rebase/enz/3641.html RefSeq NP_416469 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416469 RefSeq WP_000786005 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000786005 SMR P09184 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P09184 STRING 511145.b1960 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1960&targetmode=cogs STRING COG3727 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3727&targetmode=cogs SUPFAM SSF52980 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52980 TIGRFAMs TIGR00632 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00632 UniProtKB VSR_ECOLI http://www.uniprot.org/uniprot/VSR_ECOLI UniProtKB-AC P09184 http://www.uniprot.org/uniprot/P09184 charge swissprot:VSR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:VSR_ECOLI eggNOG COG3727 http://eggnogapi.embl.de/nog_data/html/tree/COG3727 eggNOG ENOG41090BB http://eggnogapi.embl.de/nog_data/html/tree/ENOG41090BB epestfind swissprot:VSR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:VSR_ECOLI garnier swissprot:VSR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:VSR_ECOLI helixturnhelix swissprot:VSR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:VSR_ECOLI hmoment swissprot:VSR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:VSR_ECOLI iep swissprot:VSR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:VSR_ECOLI inforesidue swissprot:VSR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:VSR_ECOLI octanol swissprot:VSR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:VSR_ECOLI pepcoil swissprot:VSR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:VSR_ECOLI pepdigest swissprot:VSR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:VSR_ECOLI pepinfo swissprot:VSR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:VSR_ECOLI pepnet swissprot:VSR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:VSR_ECOLI pepstats swissprot:VSR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:VSR_ECOLI pepwheel swissprot:VSR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:VSR_ECOLI pepwindow swissprot:VSR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:VSR_ECOLI sigcleave swissprot:VSR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:VSR_ECOLI ## Database ID URL or Descriptions # AltName MURF_ECOLI D-alanyl-D-alanine-adding enzyme {ECO 0000255|HAMAP-Rule MF_02019, ECO 0000303|PubMed 2186811} # AltName UDP-MurNAc-pentapeptide synthetase {ECO:0000303|PubMed 2668880} # BRENDA 6.3.2 2026 # BRENDA 6.3.2.10 2026 # BioGrid 4261642 416 # CATALYTIC ACTIVITY MURF_ECOLI ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D- glutamyl-L-lysine + D-alanyl-D-alanine = ADP + phosphate + UDP-N- acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D- alanine. {ECO 0000255|HAMAP-Rule MF_02019, ECO 0000269|PubMed 2186811}. # EcoGene EG10622 murF # FUNCTION MURF_ECOLI Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein. {ECO 0000255|HAMAP-Rule MF_02019, ECO 0000269|PubMed 2186811}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008766 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity; IDA:EcoCyc. # GO_function GO:0047480 UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity; IDA:EcoCyc. # GO_process GO:0007049 cell cycle; IEA:UniProtKB-KW. # GO_process GO:0008360 regulation of cell shape; IEA:UniProtKB-KW. # GO_process GO:0009252 peptidoglycan biosynthetic process; IMP:EcoCyc. # GO_process GO:0051301 cell division; IEA:UniProtKB-KW. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0007049 cell cycle # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0051301 cell division # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 3.40.1190.10 -; 1. # Gene3D 3.40.1390.10 -; 1. # Gene3D 3.90.190.20 -; 1. # HAMAP MF_02019 MurF # IntAct P11880 11 # InterPro IPR000713 Mur_ligase_N # InterPro IPR004101 Mur_ligase_C # InterPro IPR005863 UDP-N-AcMur_synth # InterPro IPR013221 Mur_ligase_cen # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00300 Lysine biosynthesis # KEGG_Pathway ko00550 Peptidoglycan biosynthesis # Organism MURF_ECOLI Escherichia coli (strain K12) # PANTHER PTHR23135:SF3 PTHR23135:SF3 # PATHWAY MURF_ECOLI Cell wall biogenesis; peptidoglycan biosynthesis. {ECO 0000255|HAMAP-Rule MF_02019, ECO 0000269|PubMed 2186811}. # PATRIC 32115277 VBIEscCol129921_0090 # PDB 1GG4 X-ray; 2.30 A; A/B=1-452 # PIR F64730 F64730 # Pfam PF01225 Mur_ligase # Pfam PF02875 Mur_ligase_C # Pfam PF08245 Mur_ligase_M # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase {ECO:0000255|HAMAP-Rule MF_02019, ECO:0000305} # RefSeq NP_414628 NC_000913.3 # RefSeq WP_000626685 NZ_LN832404.1 # SIMILARITY Belongs to the MurCDEF family. MurF subfamily. {ECO:0000255|HAMAP-Rule MF_02019, ECO:0000305}. # SUBCELLULAR LOCATION MURF_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_02019, ECO 0000269|PubMed 2186811}. # SUBUNIT Monomer. {ECO:0000269|PubMed 2186811}. # SUPFAM SSF53244 SSF53244 # SUPFAM SSF53623 SSF53623 # SUPFAM SSF63418 SSF63418 # TIGRFAMs TIGR01143 murF # eggNOG COG0770 LUCA # eggNOG ENOG4108EQQ Bacteria BLAST swissprot:MURF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MURF_ECOLI BioCyc ECOL316407:JW0084-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0084-MONOMER BioCyc EcoCyc:UDP-NACMURALGLDAPAALIG-MONOMER http://biocyc.org/getid?id=EcoCyc:UDP-NACMURALGLDAPAALIG-MONOMER BioCyc MetaCyc:UDP-NACMURALGLDAPAALIG-MONOMER http://biocyc.org/getid?id=MetaCyc:UDP-NACMURALGLDAPAALIG-MONOMER COG COG0770 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0770 DIP DIP-10281N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10281N DOI 10.1006/jmbi.2000.4215 http://dx.doi.org/10.1006/jmbi.2000.4215 DOI 10.1021/bi00461a023 http://dx.doi.org/10.1021/bi00461a023 DOI 10.1021/bi961872+ http://dx.doi.org/10.1021/bi961872+ DOI 10.1021/bi9701078 http://dx.doi.org/10.1021/bi9701078 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/17.13.5379 http://dx.doi.org/10.1093/nar/17.13.5379 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.3.2.10 {ECO:0000255|HAMAP-Rule:MF_02019, ECO:0000269|PubMed:2186811} http://www.genome.jp/dbget-bin/www_bget?EC:6.3.2.10 {ECO:0000255|HAMAP-Rule:MF_02019, ECO:0000269|PubMed:2186811} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U67891 http://www.ebi.ac.uk/ena/data/view/U67891 EMBL U67893 http://www.ebi.ac.uk/ena/data/view/U67893 EMBL X15432 http://www.ebi.ac.uk/ena/data/view/X15432 EMBL X55034 http://www.ebi.ac.uk/ena/data/view/X55034 ENZYME 6.3.2.10 {ECO:0000255|HAMAP-Rule:MF_02019, ECO:0000269|PubMed:2186811} http://enzyme.expasy.org/EC/6.3.2.10 {ECO:0000255|HAMAP-Rule:MF_02019, ECO:0000269|PubMed:2186811} EchoBASE EB0617 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0617 EcoGene EG10622 http://www.ecogene.org/geneInfo.php?eg_id=EG10622 EnsemblBacteria AAC73197 http://www.ensemblgenomes.org/id/AAC73197 EnsemblBacteria AAC73197 http://www.ensemblgenomes.org/id/AAC73197 EnsemblBacteria BAB96654 http://www.ensemblgenomes.org/id/BAB96654 EnsemblBacteria BAB96654 http://www.ensemblgenomes.org/id/BAB96654 EnsemblBacteria BAB96654 http://www.ensemblgenomes.org/id/BAB96654 EnsemblBacteria b0086 http://www.ensemblgenomes.org/id/b0086 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008766 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008766 GO_function GO:0047480 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047480 GO_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0009252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009252 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 3.40.1190.10 http://www.cathdb.info/version/latest/superfamily/3.40.1190.10 Gene3D 3.40.1390.10 http://www.cathdb.info/version/latest/superfamily/3.40.1390.10 Gene3D 3.90.190.20 http://www.cathdb.info/version/latest/superfamily/3.90.190.20 GeneID 944813 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944813 HAMAP MF_02019 http://hamap.expasy.org/unirule/MF_02019 HOGENOM HOG000268120 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000268120&db=HOGENOM6 InParanoid P11880 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P11880 IntAct P11880 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P11880* IntEnz 6.3.2.10 {ECO:0000255|HAMAP-Rule:MF_02019, ECO:0000269|PubMed:2186811} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.2.10 {ECO:0000255|HAMAP-Rule:MF_02019, ECO:0000269|PubMed:2186811} InterPro IPR000713 http://www.ebi.ac.uk/interpro/entry/IPR000713 InterPro IPR004101 http://www.ebi.ac.uk/interpro/entry/IPR004101 InterPro IPR005863 http://www.ebi.ac.uk/interpro/entry/IPR005863 InterPro IPR013221 http://www.ebi.ac.uk/interpro/entry/IPR013221 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0084 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0084 KEGG_Gene eco:b0086 http://www.genome.jp/dbget-bin/www_bget?eco:b0086 KEGG_Orthology KO:K01929 http://www.genome.jp/dbget-bin/www_bget?KO:K01929 KEGG_Pathway ko00300 http://www.genome.jp/kegg-bin/show_pathway?ko00300 KEGG_Pathway ko00550 http://www.genome.jp/kegg-bin/show_pathway?ko00550 KEGG_Reaction rn:R04573 http://www.genome.jp/dbget-bin/www_bget?rn:R04573 KEGG_Reaction rn:R04617 http://www.genome.jp/dbget-bin/www_bget?rn:R04617 MINT MINT-1227223 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1227223 OMA DYAVIEM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DYAVIEM PANTHER PTHR23135:SF3 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23135:SF3 PDB 1GG4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1GG4 PDBsum 1GG4 http://www.ebi.ac.uk/pdbsum/1GG4 PSORT swissprot:MURF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MURF_ECOLI PSORT-B swissprot:MURF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MURF_ECOLI PSORT2 swissprot:MURF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MURF_ECOLI Pfam PF01225 http://pfam.xfam.org/family/PF01225 Pfam PF02875 http://pfam.xfam.org/family/PF02875 Pfam PF08245 http://pfam.xfam.org/family/PF08245 Phobius swissprot:MURF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MURF_ECOLI PhylomeDB P11880 http://phylomedb.org/?seqid=P11880 ProteinModelPortal P11880 http://www.proteinmodelportal.org/query/uniprot/P11880 PubMed 11090285 http://www.ncbi.nlm.nih.gov/pubmed/11090285 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2186811 http://www.ncbi.nlm.nih.gov/pubmed/2186811 PubMed 2668880 http://www.ncbi.nlm.nih.gov/pubmed/2668880 PubMed 8973200 http://www.ncbi.nlm.nih.gov/pubmed/8973200 PubMed 9166795 http://www.ncbi.nlm.nih.gov/pubmed/9166795 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414628 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414628 RefSeq WP_000626685 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000626685 SMR P11880 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P11880 STRING 511145.b0086 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0086&targetmode=cogs STRING COG0770 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0770&targetmode=cogs SUPFAM SSF53244 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53244 SUPFAM SSF53623 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53623 SUPFAM SSF63418 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63418 TIGRFAMs TIGR01143 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01143 UniProtKB MURF_ECOLI http://www.uniprot.org/uniprot/MURF_ECOLI UniProtKB-AC P11880 http://www.uniprot.org/uniprot/P11880 charge swissprot:MURF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MURF_ECOLI eggNOG COG0770 http://eggnogapi.embl.de/nog_data/html/tree/COG0770 eggNOG ENOG4108EQQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108EQQ epestfind swissprot:MURF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MURF_ECOLI garnier swissprot:MURF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MURF_ECOLI helixturnhelix swissprot:MURF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MURF_ECOLI hmoment swissprot:MURF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MURF_ECOLI iep swissprot:MURF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MURF_ECOLI inforesidue swissprot:MURF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MURF_ECOLI octanol swissprot:MURF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MURF_ECOLI pepcoil swissprot:MURF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MURF_ECOLI pepdigest swissprot:MURF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MURF_ECOLI pepinfo swissprot:MURF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MURF_ECOLI pepnet swissprot:MURF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MURF_ECOLI pepstats swissprot:MURF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MURF_ECOLI pepwheel swissprot:MURF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MURF_ECOLI pepwindow swissprot:MURF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MURF_ECOLI sigcleave swissprot:MURF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MURF_ECOLI ## Database ID URL or Descriptions # BioGrid 4260557 148 # DISRUPTION PHENOTYPE Mutants are more sensitive to nalidixic acid, mitomycin C and other stresses such as hydrogen peroxide or UV irradiation. {ECO:0000269|PubMed 20128927}. # EcoGene EG13282 emrK # FUNCTION EMRK_ECOLI Part of the tripartite efflux system EmrYK-TolC, which confers resistance to various drugs. {ECO 0000250}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015238 drug transmembrane transporter activity; IEA:InterPro. # GO_process GO:0006974 cellular response to DNA damage stimulus; IMP:EcoCyc. # GO_process GO:0046677 response to antibiotic; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # INDUCTION Growth phase-dependent transcription is induced by tetracycline. Expression may be controlled by both RpoS and the Mar system. {ECO:0000269|PubMed 12501312}. # InterPro IPR005694 Emr # InterPro IPR006143 RND_pump_MFP # InterPro IPR032317 HlyD_D23 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko02020 Two-component system # Organism EMRK_ECOLI Escherichia coli (strain K12) # PATRIC 32120115 VBIEscCol129921_2466 # PIR E65010 E65010 # Pfam PF00529 HlyD # Pfam PF16576 HlyD_D23 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EMRK_ECOLI Probable multidrug resistance protein EmrK # RefSeq NP_416869 NC_000913.3 # RefSeq WP_000435167 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA11236.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. {ECO 0000305}. # SUBCELLULAR LOCATION EMRK_ECOLI Cell inner membrane {ECO 0000305}; Single- pass membrane protein {ECO 0000305}; Periplasmic side {ECO 0000305}. # SUBUNIT Part of the tripartite efflux system EmrYK-TolC, which is composed of an inner membrane transporter, EmrY, a membrane fusion protein, EmrK, and an outer membrane component, TolC. The complex forms a large protein conduit and can translocate molecules across both the inner and outer membranes (By similarity). {ECO 0000250}. # TIGRFAMs TIGR00998 8a0101 # eggNOG COG1566 LUCA # eggNOG ENOG4105CW7 Bacteria BLAST swissprot:EMRK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EMRK_ECOLI BioCyc ECOL316407:JW2365-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2365-MONOMER BioCyc EcoCyc:G7233-MONOMER http://biocyc.org/getid?id=EcoCyc:G7233-MONOMER COG COG1566 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1566 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1186/1471-2180-10-35 http://dx.doi.org/10.1186/1471-2180-10-35 DOI 10.2323/jgam.43.257 http://dx.doi.org/10.2323/jgam.43.257 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D78168 http://www.ebi.ac.uk/ena/data/view/D78168 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3067 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3067 EcoGene EG13282 http://www.ecogene.org/geneInfo.php?eg_id=EG13282 EnsemblBacteria AAC75427 http://www.ensemblgenomes.org/id/AAC75427 EnsemblBacteria AAC75427 http://www.ensemblgenomes.org/id/AAC75427 EnsemblBacteria BAA16239 http://www.ensemblgenomes.org/id/BAA16239 EnsemblBacteria BAA16239 http://www.ensemblgenomes.org/id/BAA16239 EnsemblBacteria BAA16239 http://www.ensemblgenomes.org/id/BAA16239 EnsemblBacteria b2368 http://www.ensemblgenomes.org/id/b2368 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015238 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015238 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 946840 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946840 HOGENOM HOG000112072 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000112072&db=HOGENOM6 InParanoid P52599 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P52599 InterPro IPR005694 http://www.ebi.ac.uk/interpro/entry/IPR005694 InterPro IPR006143 http://www.ebi.ac.uk/interpro/entry/IPR006143 InterPro IPR032317 http://www.ebi.ac.uk/interpro/entry/IPR032317 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW2365 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2365 KEGG_Gene eco:b2368 http://www.genome.jp/dbget-bin/www_bget?eco:b2368 KEGG_Orthology KO:K07797 http://www.genome.jp/dbget-bin/www_bget?KO:K07797 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA LDQLWID http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LDQLWID PSORT swissprot:EMRK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EMRK_ECOLI PSORT-B swissprot:EMRK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EMRK_ECOLI PSORT2 swissprot:EMRK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EMRK_ECOLI Pfam PF00529 http://pfam.xfam.org/family/PF00529 Pfam PF16576 http://pfam.xfam.org/family/PF16576 Phobius swissprot:EMRK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EMRK_ECOLI PhylomeDB P52599 http://phylomedb.org/?seqid=P52599 ProteinModelPortal P52599 http://www.proteinmodelportal.org/query/uniprot/P52599 PubMed 12501312 http://www.ncbi.nlm.nih.gov/pubmed/12501312 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20128927 http://www.ncbi.nlm.nih.gov/pubmed/20128927 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416869 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416869 RefSeq WP_000435167 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000435167 SMR P52599 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P52599 STRING 511145.b2368 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2368&targetmode=cogs STRING COG1566 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1566&targetmode=cogs TIGRFAMs TIGR00998 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00998 UniProtKB EMRK_ECOLI http://www.uniprot.org/uniprot/EMRK_ECOLI UniProtKB-AC P52599 http://www.uniprot.org/uniprot/P52599 charge swissprot:EMRK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EMRK_ECOLI eggNOG COG1566 http://eggnogapi.embl.de/nog_data/html/tree/COG1566 eggNOG ENOG4105CW7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CW7 epestfind swissprot:EMRK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EMRK_ECOLI garnier swissprot:EMRK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EMRK_ECOLI helixturnhelix swissprot:EMRK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EMRK_ECOLI hmoment swissprot:EMRK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EMRK_ECOLI iep swissprot:EMRK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EMRK_ECOLI inforesidue swissprot:EMRK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EMRK_ECOLI octanol swissprot:EMRK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EMRK_ECOLI pepcoil swissprot:EMRK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EMRK_ECOLI pepdigest swissprot:EMRK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EMRK_ECOLI pepinfo swissprot:EMRK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EMRK_ECOLI pepnet swissprot:EMRK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EMRK_ECOLI pepstats swissprot:EMRK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EMRK_ECOLI pepwheel swissprot:EMRK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EMRK_ECOLI pepwindow swissprot:EMRK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EMRK_ECOLI sigcleave swissprot:EMRK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EMRK_ECOLI ## Database ID URL or Descriptions # AltName FHUE_ECOLI Outer-membrane receptor for Fe(III)-coprogen, Fe(III)-ferrioxamine B and Fe(III)-rhodotrulic acid # BioGrid 4260942 181 # EcoGene EG10306 fhuE # FUNCTION FHUE_ECOLI Required for the uptake of Fe(3+) via coprogen, ferrioxamine B, and rhodotorulic acid. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0004872 receptor activity; IEA:InterPro. # GO_function GO:0005506 iron ion binding; IEA:InterPro. # GO_function GO:0015344 siderophore uptake transmembrane transporter activity; IBA:GO_Central. # GO_process GO:0055072 iron ion homeostasis; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0042592 homeostatic process # Gene3D 2.170.130.10 -; 1. # Gene3D 2.40.170.20 -; 1. # INDUCTION For induction, the TonB and the ExbB proteins have to be active. Induced by hydroxyurea (PubMed:20005847). {ECO 0000269|PubMed:20005847}. # InterPro IPR000531 TonB-dep_rcpt_b-brl # InterPro IPR010105 TonB_sidphr_rcpt # InterPro IPR010916 TonB_box_CS # InterPro IPR010917 TonB_rcpt_CS # InterPro IPR012910 Plug_dom # KEGG_Brite ko02000 Transporters # Organism FHUE_ECOLI Escherichia coli (strain K12) # PATRIC 32117445 VBIEscCol129921_1145 # PIR C64854 C64854 # PROSITE PS00430 TONB_DEPENDENT_REC_1 # PROSITE PS01156 TONB_DEPENDENT_REC_2 # Pfam PF00593 TonB_dep_Rec # Pfam PF07715 Plug # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FHUE_ECOLI FhuE receptor # RefSeq NP_415620 NC_000913.3 # RefSeq WP_000953441 NZ_LN832404.1 # SIMILARITY Belongs to the TonB-dependent receptor family. {ECO 0000305}. # SUBCELLULAR LOCATION FHUE_ECOLI Cell outer membrane. # TCDB 1.B.14.1 the outer membrane receptor (omr) family # TIGRFAMs TIGR01783 TonB-siderophor # eggNOG COG4773 LUCA # eggNOG ENOG4105CNM Bacteria BLAST swissprot:FHUE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FHUE_ECOLI BioCyc ECOL316407:JW1088-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1088-MONOMER BioCyc EcoCyc:EG10306-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10306-MONOMER BioCyc MetaCyc:EG10306-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10306-MONOMER COG COG4773 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4773 DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1990.tb00609.x http://dx.doi.org/10.1111/j.1365-2958.1990.tb00609.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X17615 http://www.ebi.ac.uk/ena/data/view/X17615 EchoBASE EB0302 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0302 EcoGene EG10306 http://www.ecogene.org/geneInfo.php?eg_id=EG10306 EnsemblBacteria AAC74186 http://www.ensemblgenomes.org/id/AAC74186 EnsemblBacteria AAC74186 http://www.ensemblgenomes.org/id/AAC74186 EnsemblBacteria BAA35909 http://www.ensemblgenomes.org/id/BAA35909 EnsemblBacteria BAA35909 http://www.ensemblgenomes.org/id/BAA35909 EnsemblBacteria BAA35909 http://www.ensemblgenomes.org/id/BAA35909 EnsemblBacteria b1102 http://www.ensemblgenomes.org/id/b1102 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0004872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004872 GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0015344 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015344 GO_process GO:0055072 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055072 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 Gene3D 2.170.130.10 http://www.cathdb.info/version/latest/superfamily/2.170.130.10 Gene3D 2.40.170.20 http://www.cathdb.info/version/latest/superfamily/2.40.170.20 GeneID 945649 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945649 HOGENOM HOG000217242 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000217242&db=HOGENOM6 InParanoid P16869 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P16869 InterPro IPR000531 http://www.ebi.ac.uk/interpro/entry/IPR000531 InterPro IPR010105 http://www.ebi.ac.uk/interpro/entry/IPR010105 InterPro IPR010916 http://www.ebi.ac.uk/interpro/entry/IPR010916 InterPro IPR010917 http://www.ebi.ac.uk/interpro/entry/IPR010917 InterPro IPR012910 http://www.ebi.ac.uk/interpro/entry/IPR012910 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1088 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1088 KEGG_Gene eco:b1102 http://www.genome.jp/dbget-bin/www_bget?eco:b1102 KEGG_Orthology KO:K16088 http://www.genome.jp/dbget-bin/www_bget?KO:K16088 OMA YDTNMEG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YDTNMEG PROSITE PS00430 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00430 PROSITE PS01156 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01156 PSORT swissprot:FHUE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FHUE_ECOLI PSORT-B swissprot:FHUE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FHUE_ECOLI PSORT2 swissprot:FHUE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FHUE_ECOLI Pfam PF00593 http://pfam.xfam.org/family/PF00593 Pfam PF07715 http://pfam.xfam.org/family/PF07715 Phobius swissprot:FHUE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FHUE_ECOLI PhylomeDB P16869 http://phylomedb.org/?seqid=P16869 ProteinModelPortal P16869 http://www.proteinmodelportal.org/query/uniprot/P16869 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 2162465 http://www.ncbi.nlm.nih.gov/pubmed/2162465 PubMed 3032906 http://www.ncbi.nlm.nih.gov/pubmed/3032906 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415620 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415620 RefSeq WP_000953441 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000953441 STRING 511145.b1102 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1102&targetmode=cogs STRING COG4773 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4773&targetmode=cogs TCDB 1.B.14.1 http://www.tcdb.org/search/result.php?tc=1.B.14.1 TIGRFAMs TIGR01783 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01783 UniProtKB FHUE_ECOLI http://www.uniprot.org/uniprot/FHUE_ECOLI UniProtKB-AC P16869 http://www.uniprot.org/uniprot/P16869 charge swissprot:FHUE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FHUE_ECOLI eggNOG COG4773 http://eggnogapi.embl.de/nog_data/html/tree/COG4773 eggNOG ENOG4105CNM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CNM epestfind swissprot:FHUE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FHUE_ECOLI garnier swissprot:FHUE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FHUE_ECOLI helixturnhelix swissprot:FHUE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FHUE_ECOLI hmoment swissprot:FHUE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FHUE_ECOLI iep swissprot:FHUE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FHUE_ECOLI inforesidue swissprot:FHUE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FHUE_ECOLI octanol swissprot:FHUE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FHUE_ECOLI pepcoil swissprot:FHUE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FHUE_ECOLI pepdigest swissprot:FHUE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FHUE_ECOLI pepinfo swissprot:FHUE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FHUE_ECOLI pepnet swissprot:FHUE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FHUE_ECOLI pepstats swissprot:FHUE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FHUE_ECOLI pepwheel swissprot:FHUE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FHUE_ECOLI pepwindow swissprot:FHUE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FHUE_ECOLI sigcleave swissprot:FHUE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FHUE_ECOLI ## Database ID URL or Descriptions # FUNCTION TRAK1_ECOLI Involved in pilus assembly. # GO_component GO:0009279 cell outer membrane; IEA:UniProtKB-SubCell. # GO_process GO:0000746 conjugation; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0008150 biological_process # InterPro IPR010563 Pilus_assembly_TraK # InterPro IPR014126 TraK_Ftype # Organism TRAK1_ECOLI Escherichia coli (strain K12) # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF06586 TraK # RecName TRAK1_ECOLI TraK lipoprotein # RefSeq NP_061456 NC_002483.1 # RefSeq NP_862922 NC_004998.1 # RefSeq WP_001230787 NZ_CP014273.1 # RefSeq YP_001965445 NC_010862.1 # RefSeq YP_003108305 NC_013122.1 # RefSeq YP_003162580 NC_013175.1 # RefSeq YP_003937620 NC_014615.1 # RefSeq YP_006953523 NC_019073.1 # RefSeq YP_008997955 NC_023315.1 # RefSeq YP_009060153 NC_024956.1 # RefSeq YP_009068348 NC_025139.1 # RefSeq YP_009068621 NC_025141.1 # RefSeq YP_009070613 NC_025175.1 # RefSeq YP_009070970 NC_025177.1 # RefSeq YP_009071233 NC_025179.1 # RefSeq YP_190141 NC_006671.1 # SUBCELLULAR LOCATION TRAK1_ECOLI Cell outer membrane {ECO 0000305}; Lipid- anchor {ECO 0000255|PROSITE-ProRule PRU00303}. # TIGRFAMs TIGR02756 TraK_Ftype BLAST swissprot:TRAK1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRAK1_ECOLI DIP DIP-16928N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-16928N EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL U01159 http://www.ebi.ac.uk/ena/data/view/U01159 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_process GO:0000746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000746 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 1263586 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263586 GeneID 13906449 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13906449 GeneID 1446486 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1446486 GeneID 18194781 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18194781 GeneID 20466903 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20466903 GeneID 20491478 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20491478 GeneID 20491753 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20491753 GeneID 20492681 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20492681 GeneID 20493040 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20493040 GeneID 20493305 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20493305 GeneID 3244813 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3244813 GeneID 6382241 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6382241 GeneID 8319235 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8319235 GeneID 8381927 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8381927 GeneID 9846147 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9846147 InterPro IPR010563 http://www.ebi.ac.uk/interpro/entry/IPR010563 InterPro IPR014126 http://www.ebi.ac.uk/interpro/entry/IPR014126 OMA PFENDAA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PFENDAA PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:TRAK1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRAK1_ECOLI PSORT-B swissprot:TRAK1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRAK1_ECOLI PSORT2 swissprot:TRAK1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRAK1_ECOLI Pfam PF06586 http://pfam.xfam.org/family/PF06586 Phobius swissprot:TRAK1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRAK1_ECOLI ProteinModelPortal P41066 http://www.proteinmodelportal.org/query/uniprot/P41066 PubMed 7915817 http://www.ncbi.nlm.nih.gov/pubmed/7915817 RefSeq NP_061456 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061456 RefSeq NP_862922 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_862922 RefSeq WP_001230787 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001230787 RefSeq YP_001965445 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001965445 RefSeq YP_003108305 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_003108305 RefSeq YP_003162580 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_003162580 RefSeq YP_003937620 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_003937620 RefSeq YP_006953523 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_006953523 RefSeq YP_008997955 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_008997955 RefSeq YP_009060153 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009060153 RefSeq YP_009068348 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009068348 RefSeq YP_009068621 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009068621 RefSeq YP_009070613 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009070613 RefSeq YP_009070970 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009070970 RefSeq YP_009071233 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009071233 RefSeq YP_190141 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_190141 TIGRFAMs TIGR02756 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02756 UniProtKB TRAK1_ECOLI http://www.uniprot.org/uniprot/TRAK1_ECOLI UniProtKB-AC P41066 http://www.uniprot.org/uniprot/P41066 charge swissprot:TRAK1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRAK1_ECOLI epestfind swissprot:TRAK1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRAK1_ECOLI garnier swissprot:TRAK1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRAK1_ECOLI helixturnhelix swissprot:TRAK1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRAK1_ECOLI hmoment swissprot:TRAK1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRAK1_ECOLI iep swissprot:TRAK1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRAK1_ECOLI inforesidue swissprot:TRAK1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRAK1_ECOLI octanol swissprot:TRAK1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRAK1_ECOLI pepcoil swissprot:TRAK1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRAK1_ECOLI pepdigest swissprot:TRAK1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRAK1_ECOLI pepinfo swissprot:TRAK1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRAK1_ECOLI pepnet swissprot:TRAK1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRAK1_ECOLI pepstats swissprot:TRAK1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRAK1_ECOLI pepwheel swissprot:TRAK1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRAK1_ECOLI pepwindow swissprot:TRAK1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRAK1_ECOLI sigcleave swissprot:TRAK1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRAK1_ECOLI ## Database ID URL or Descriptions # BioGrid 4260837 11 # DISRUPTION PHENOTYPE Mutant shows a decrease in the ratio of methylthiolated to unmodified S12 and a decrease in transcription of a subset of genes. {ECO:0000269|PubMed 21169565}. # EcoGene EG13699 ycaO # FUNCTION YCAO_ECOLI Involved in beta-methylthiolation of ribosomal protein S12. {ECO 0000269|PubMed 21169565}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0047693 ATP diphosphatase activity; IDA:EcoCyc. # GO_process GO:0018339 peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # IntAct P75838 7 # InterPro IPR003776 YcaO-like_dom # KEGG_Brite ko03009 Ribosome biogenesis # Organism YCAO_ECOLI Escherichia coli (strain K12) # PATRIC 32117023 VBIEscCol129921_0936 # PDB 4Q84 X-ray; 2.64 A; A/B=1-586 # PDB 4Q85 X-ray; 3.29 A; A/B/C/D/E/F/G/H=1-586 # PDB 4Q86 X-ray; 2.25 A; A/B/C/D/E/F/G/H=1-586 # PIR H64829 H64829 # PROSITE PS51664 YCAO # Pfam PF02624 YcaO # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCAO_ECOLI Ribosomal protein S12 methylthiotransferase accessory factor YcaO # RefSeq NP_415425 NC_000913.3 # RefSeq WP_001295344 NZ_LN832404.1 # SIMILARITY Contains 1 YcaO domain. {ECO:0000255|PROSITE- ProRule PRU00999}. # SUBUNIT Interacts with the ribosomal small subunit. {ECO:0000269|PubMed 21169565}. # TIGRFAMs TIGR00702 TIGR00702 # eggNOG COG1944 LUCA # eggNOG ENOG4105DDY Bacteria BLAST swissprot:YCAO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCAO_ECOLI BioCyc ECOL316407:JW0888-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0888-MONOMER BioCyc EcoCyc:G6468-MONOMER http://biocyc.org/getid?id=EcoCyc:G6468-MONOMER BioCyc MetaCyc:G6468-MONOMER http://biocyc.org/getid?id=MetaCyc:G6468-MONOMER COG COG1944 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1944 DIP DIP-11470N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11470N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/mcp.M110.005199 http://dx.doi.org/10.1074/mcp.M110.005199 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3463 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3463 EcoGene EG13699 http://www.ecogene.org/geneInfo.php?eg_id=EG13699 EnsemblBacteria AAC73991 http://www.ensemblgenomes.org/id/AAC73991 EnsemblBacteria AAC73991 http://www.ensemblgenomes.org/id/AAC73991 EnsemblBacteria BAA35640 http://www.ensemblgenomes.org/id/BAA35640 EnsemblBacteria BAA35640 http://www.ensemblgenomes.org/id/BAA35640 EnsemblBacteria BAA35640 http://www.ensemblgenomes.org/id/BAA35640 EnsemblBacteria b0905 http://www.ensemblgenomes.org/id/b0905 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0047693 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047693 GO_process GO:0018339 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018339 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GeneID 945509 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945509 HOGENOM HOG000276724 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276724&db=HOGENOM6 InParanoid P75838 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75838 IntAct P75838 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75838* InterPro IPR003776 http://www.ebi.ac.uk/interpro/entry/IPR003776 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW0888 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0888 KEGG_Gene eco:b0905 http://www.genome.jp/dbget-bin/www_bget?eco:b0905 KEGG_Orthology KO:K09136 http://www.genome.jp/dbget-bin/www_bget?KO:K09136 MINT MINT-1240855 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1240855 OMA EFVEWDF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EFVEWDF PDB 4Q84 http://www.ebi.ac.uk/pdbe-srv/view/entry/4Q84 PDB 4Q85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4Q85 PDB 4Q86 http://www.ebi.ac.uk/pdbe-srv/view/entry/4Q86 PDBsum 4Q84 http://www.ebi.ac.uk/pdbsum/4Q84 PDBsum 4Q85 http://www.ebi.ac.uk/pdbsum/4Q85 PDBsum 4Q86 http://www.ebi.ac.uk/pdbsum/4Q86 PROSITE PS51664 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51664 PSORT swissprot:YCAO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCAO_ECOLI PSORT-B swissprot:YCAO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCAO_ECOLI PSORT2 swissprot:YCAO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCAO_ECOLI Pfam PF02624 http://pfam.xfam.org/family/PF02624 Phobius swissprot:YCAO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCAO_ECOLI ProteinModelPortal P75838 http://www.proteinmodelportal.org/query/uniprot/P75838 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21169565 http://www.ncbi.nlm.nih.gov/pubmed/21169565 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415425 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415425 RefSeq WP_001295344 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295344 SMR P75838 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75838 STRING 511145.b0905 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0905&targetmode=cogs STRING COG1944 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1944&targetmode=cogs TIGRFAMs TIGR00702 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00702 UniProtKB YCAO_ECOLI http://www.uniprot.org/uniprot/YCAO_ECOLI UniProtKB-AC P75838 http://www.uniprot.org/uniprot/P75838 charge swissprot:YCAO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCAO_ECOLI eggNOG COG1944 http://eggnogapi.embl.de/nog_data/html/tree/COG1944 eggNOG ENOG4105DDY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DDY epestfind swissprot:YCAO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCAO_ECOLI garnier swissprot:YCAO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCAO_ECOLI helixturnhelix swissprot:YCAO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCAO_ECOLI hmoment swissprot:YCAO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCAO_ECOLI iep swissprot:YCAO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCAO_ECOLI inforesidue swissprot:YCAO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCAO_ECOLI octanol swissprot:YCAO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCAO_ECOLI pepcoil swissprot:YCAO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCAO_ECOLI pepdigest swissprot:YCAO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCAO_ECOLI pepinfo swissprot:YCAO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCAO_ECOLI pepnet swissprot:YCAO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCAO_ECOLI pepstats swissprot:YCAO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCAO_ECOLI pepwheel swissprot:YCAO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCAO_ECOLI pepwindow swissprot:YCAO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCAO_ECOLI sigcleave swissprot:YCAO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCAO_ECOLI ## Database ID URL or Descriptions # AltName Acetate SH-citrate lyase ligase # AltName CITC_ECOLI Citrate lyase synthetase # BioGrid 4259904 14 # CATALYTIC ACTIVITY CITC_ECOLI ATP + acetate + [citrate (pro-3S)-lyase](thiol form) = AMP + diphosphate + [citrate (pro-3S)-lyase](acetyl form). # DrugBank DB00336 Nitrofural # EcoGene EG13645 citC # FUNCTION CITC_ECOLI Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0008080 N-acetyltransferase activity; IEA:InterPro. # GO_function GO:0008771 [citrate (pro-3S)-lyase] ligase activity; IDA:EcoCyc. # GO_process GO:0006464 cellular protein modification process; IDA:EcoCyc. # GO_process GO:0009058 biosynthetic process; IEA:InterPro. # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.620 -; 1. # Gene3D 3.40.630.30 -; 1. # INDUCTION Repressed by H-NS. Part of the citCDEFXG operon. {ECO:0000269|PubMed 19429622}. # INTERACTION CITC_ECOLI P0A8D3 yaiI; NbExp=2; IntAct=EBI-1119239, EBI-1116378; # IntAct P77390 9 # InterPro IPR000182 GNAT_dom # InterPro IPR004821 Cyt_trans-like # InterPro IPR005216 Citrate_lyase_ligase # InterPro IPR013166 Citrate_lyase_ligase_C # InterPro IPR014729 Rossmann-like_a/b/a_fold # InterPro IPR016181 Acyl_CoA_acyltransferase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko02020 Two-component system # Organism CITC_ECOLI Escherichia coli (strain K12) # PATRIC 32116416 VBIEscCol129921_0648 # PIR H64795 H64795 # PIRSF PIRSF005751 Acet_citr_lig # PROSITE PS51186 GNAT # Pfam PF08218 Citrate_ly_lig # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CITC_ECOLI [Citrate [pro-3S]-lyase] ligase # RefSeq NP_415151 NC_000913.3 # RefSeq WP_000467705 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40818.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Contains 1 N-acetyltransferase domain. {ECO:0000255|PROSITE-ProRule PRU00532}. # SMART SM00764 Citrate_ly_lig # SUPFAM SSF55729 SSF55729 # TIGRFAMs TIGR00124 cit_ly_ligase # TIGRFAMs TIGR00125 cyt_tran_rel # eggNOG COG3053 LUCA # eggNOG ENOG4105DUA Bacteria BLAST swissprot:CITC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CITC_ECOLI BioCyc ECOL316407:JW0610-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0610-MONOMER BioCyc EcoCyc:CITC-MONOMER http://biocyc.org/getid?id=EcoCyc:CITC-MONOMER COG COG3053 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3053 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00108-09 http://dx.doi.org/10.1128/JB.00108-09 DrugBank DB00336 http://www.drugbank.ca/drugs/DB00336 EC_number EC:6.2.1.22 http://www.genome.jp/dbget-bin/www_bget?EC:6.2.1.22 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U46667 http://www.ebi.ac.uk/ena/data/view/U46667 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 ENZYME 6.2.1.22 http://enzyme.expasy.org/EC/6.2.1.22 EchoBASE EB3409 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3409 EcoGene EG13645 http://www.ecogene.org/geneInfo.php?eg_id=EG13645 EnsemblBacteria AAC73719 http://www.ensemblgenomes.org/id/AAC73719 EnsemblBacteria AAC73719 http://www.ensemblgenomes.org/id/AAC73719 EnsemblBacteria BAA35254 http://www.ensemblgenomes.org/id/BAA35254 EnsemblBacteria BAA35254 http://www.ensemblgenomes.org/id/BAA35254 EnsemblBacteria BAA35254 http://www.ensemblgenomes.org/id/BAA35254 EnsemblBacteria b0618 http://www.ensemblgenomes.org/id/b0618 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008080 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008080 GO_function GO:0008771 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008771 GO_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GO_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 Gene3D 3.40.630.30 http://www.cathdb.info/version/latest/superfamily/3.40.630.30 GeneID 945231 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945231 HOGENOM HOG000117934 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117934&db=HOGENOM6 InParanoid P77390 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77390 IntAct P77390 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77390* IntEnz 6.2.1.22 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.2.1.22 InterPro IPR000182 http://www.ebi.ac.uk/interpro/entry/IPR000182 InterPro IPR004821 http://www.ebi.ac.uk/interpro/entry/IPR004821 InterPro IPR005216 http://www.ebi.ac.uk/interpro/entry/IPR005216 InterPro IPR013166 http://www.ebi.ac.uk/interpro/entry/IPR013166 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 InterPro IPR016181 http://www.ebi.ac.uk/interpro/entry/IPR016181 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0610 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0610 KEGG_Gene eco:b0618 http://www.genome.jp/dbget-bin/www_bget?eco:b0618 KEGG_Orthology KO:K01910 http://www.genome.jp/dbget-bin/www_bget?KO:K01910 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA KGHQYLV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KGHQYLV PROSITE PS51186 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51186 PSORT swissprot:CITC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CITC_ECOLI PSORT-B swissprot:CITC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CITC_ECOLI PSORT2 swissprot:CITC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CITC_ECOLI Pfam PF08218 http://pfam.xfam.org/family/PF08218 Phobius swissprot:CITC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CITC_ECOLI PhylomeDB P77390 http://phylomedb.org/?seqid=P77390 ProteinModelPortal P77390 http://www.proteinmodelportal.org/query/uniprot/P77390 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19429622 http://www.ncbi.nlm.nih.gov/pubmed/19429622 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415151 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415151 RefSeq WP_000467705 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000467705 SMART SM00764 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00764 STRING 511145.b0618 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0618&targetmode=cogs STRING COG3053 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3053&targetmode=cogs SUPFAM SSF55729 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55729 TIGRFAMs TIGR00124 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00124 TIGRFAMs TIGR00125 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00125 UniProtKB CITC_ECOLI http://www.uniprot.org/uniprot/CITC_ECOLI UniProtKB-AC P77390 http://www.uniprot.org/uniprot/P77390 charge swissprot:CITC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CITC_ECOLI eggNOG COG3053 http://eggnogapi.embl.de/nog_data/html/tree/COG3053 eggNOG ENOG4105DUA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DUA epestfind swissprot:CITC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CITC_ECOLI garnier swissprot:CITC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CITC_ECOLI helixturnhelix swissprot:CITC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CITC_ECOLI hmoment swissprot:CITC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CITC_ECOLI iep swissprot:CITC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CITC_ECOLI inforesidue swissprot:CITC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CITC_ECOLI octanol swissprot:CITC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CITC_ECOLI pepcoil swissprot:CITC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CITC_ECOLI pepdigest swissprot:CITC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CITC_ECOLI pepinfo swissprot:CITC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CITC_ECOLI pepnet swissprot:CITC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CITC_ECOLI pepstats swissprot:CITC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CITC_ECOLI pepwheel swissprot:CITC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CITC_ECOLI pepwindow swissprot:CITC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CITC_ECOLI sigcleave swissprot:CITC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CITC_ECOLI ## Database ID URL or Descriptions # BioGrid 4260980 351 # EcoGene EG10294 fepB # FUNCTION FEPB_ECOLI Binds ferrienterobactin; part of the binding-protein- dependent transport system for uptake of ferrienterobactin. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IDA:EcoCyc. # GO_process GO:0006811 ion transport; IEA:UniProtKB-KW. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0055072 iron ion homeostasis; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043234 protein complex # GOslim_process GO:0006810 transport # GOslim_process GO:0006950 response to stress # GOslim_process GO:0042592 homeostatic process # INDUCTION Controlled in part by the amount of available iron. Induced by hydroxyurea (PubMed:20005847). {ECO 0000269|PubMed:20005847}. # IntAct P0AEL6 14 # InterPro IPR002491 ABC_transptr_periplasmic_BD # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00240 Iron complex transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism FEPB_ECOLI Escherichia coli (strain K12) # PATRIC 32116360 VBIEscCol129921_0620 # PDB 2M6K NMR; -; A=27-318 # PDB 2M6L NMR; -; A=27-318 # PDB 3TLK X-ray; 1.85 A; A/B/C=1-318 # PIR JV0045 JV0045 # PROSITE PS50983 FE_B12_PBP # Pfam PF01497 Peripla_BP_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FEPB_ECOLI Ferrienterobactin-binding periplasmic protein # RefSeq NP_415124 NC_000913.3 # RefSeq WP_001234311 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial solute-binding protein 8 family. {ECO 0000305}. # SIMILARITY Contains 1 Fe/B12 periplasmic-binding domain. {ECO:0000255|PROSITE-ProRule PRU00344}. # SUBCELLULAR LOCATION FEPB_ECOLI Periplasm. # eggNOG COG4592 LUCA # eggNOG ENOG4105PEC Bacteria BLAST swissprot:FEPB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FEPB_ECOLI BioCyc ECOL316407:JW0584-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0584-MONOMER BioCyc EcoCyc:FEPB-MONOMER http://biocyc.org/getid?id=EcoCyc:FEPB-MONOMER BioCyc MetaCyc:FEPB-MONOMER http://biocyc.org/getid?id=MetaCyc:FEPB-MONOMER COG COG0614 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0614 DIP DIP-9593N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9593N DOI 10.1016/0022-2836(90)90229-F http://dx.doi.org/10.1016/0022-2836(90)90229-F DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1099/13500872-141-7-1647 http://dx.doi.org/10.1099/13500872-141-7-1647 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M29730 http://www.ebi.ac.uk/ena/data/view/M29730 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EMBL X53274 http://www.ebi.ac.uk/ena/data/view/X53274 EchoBASE EB0290 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0290 EcoGene EG10294 http://www.ecogene.org/geneInfo.php?eg_id=EG10294 EnsemblBacteria AAC73693 http://www.ensemblgenomes.org/id/AAC73693 EnsemblBacteria AAC73693 http://www.ensemblgenomes.org/id/AAC73693 EnsemblBacteria BAE76347 http://www.ensemblgenomes.org/id/BAE76347 EnsemblBacteria BAE76347 http://www.ensemblgenomes.org/id/BAE76347 EnsemblBacteria BAE76347 http://www.ensemblgenomes.org/id/BAE76347 EnsemblBacteria b0592 http://www.ensemblgenomes.org/id/b0592 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_process GO:0006811 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0055072 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055072 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GeneID 947538 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947538 HOGENOM HOG000117867 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117867&db=HOGENOM6 InParanoid P0AEL6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEL6 IntAct P0AEL6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEL6* InterPro IPR002491 http://www.ebi.ac.uk/interpro/entry/IPR002491 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0584 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0584 KEGG_Gene eco:b0592 http://www.genome.jp/dbget-bin/www_bget?eco:b0592 KEGG_Orthology KO:K02016 http://www.genome.jp/dbget-bin/www_bget?KO:K02016 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA EIAPTIM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EIAPTIM PDB 2M6K http://www.ebi.ac.uk/pdbe-srv/view/entry/2M6K PDB 2M6L http://www.ebi.ac.uk/pdbe-srv/view/entry/2M6L PDB 3TLK http://www.ebi.ac.uk/pdbe-srv/view/entry/3TLK PDBsum 2M6K http://www.ebi.ac.uk/pdbsum/2M6K PDBsum 2M6L http://www.ebi.ac.uk/pdbsum/2M6L PDBsum 3TLK http://www.ebi.ac.uk/pdbsum/3TLK PROSITE PS50983 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50983 PSORT swissprot:FEPB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FEPB_ECOLI PSORT-B swissprot:FEPB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FEPB_ECOLI PSORT2 swissprot:FEPB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FEPB_ECOLI Pfam PF01497 http://pfam.xfam.org/family/PF01497 Phobius swissprot:FEPB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FEPB_ECOLI PhylomeDB P0AEL6 http://phylomedb.org/?seqid=P0AEL6 ProteinModelPortal P0AEL6 http://www.proteinmodelportal.org/query/uniprot/P0AEL6 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 2139473 http://www.ncbi.nlm.nih.gov/pubmed/2139473 PubMed 2529253 http://www.ncbi.nlm.nih.gov/pubmed/2529253 PubMed 7551033 http://www.ncbi.nlm.nih.gov/pubmed/7551033 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415124 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415124 RefSeq WP_001234311 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001234311 SMR P0AEL6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEL6 STRING 511145.b0592 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0592&targetmode=cogs STRING COG0614 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0614&targetmode=cogs UniProtKB FEPB_ECOLI http://www.uniprot.org/uniprot/FEPB_ECOLI UniProtKB-AC P0AEL6 http://www.uniprot.org/uniprot/P0AEL6 charge swissprot:FEPB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FEPB_ECOLI eggNOG COG4592 http://eggnogapi.embl.de/nog_data/html/tree/COG4592 eggNOG ENOG4105PEC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105PEC epestfind swissprot:FEPB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FEPB_ECOLI garnier swissprot:FEPB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FEPB_ECOLI helixturnhelix swissprot:FEPB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FEPB_ECOLI hmoment swissprot:FEPB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FEPB_ECOLI iep swissprot:FEPB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FEPB_ECOLI inforesidue swissprot:FEPB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FEPB_ECOLI octanol swissprot:FEPB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FEPB_ECOLI pepcoil swissprot:FEPB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FEPB_ECOLI pepdigest swissprot:FEPB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FEPB_ECOLI pepinfo swissprot:FEPB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FEPB_ECOLI pepnet swissprot:FEPB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FEPB_ECOLI pepstats swissprot:FEPB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FEPB_ECOLI pepwheel swissprot:FEPB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FEPB_ECOLI pepwindow swissprot:FEPB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FEPB_ECOLI sigcleave swissprot:FEPB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FEPB_ECOLI ## Database ID URL or Descriptions # AltName 5'-phosphoribosylglycinamide transformylase {ECO:0000255|HAMAP-Rule MF_01930} # AltName GAR transformylase {ECO:0000255|HAMAP-Rule MF_01930} # BIOPHYSICOCHEMICAL PROPERTIES PUR3_ECOLI Kinetic parameters KM=77.5 uM for (6R)-N10-formyltetrahydrofolate (at pH 8.5) {ECO 0000269|PubMed 2185839}; KM=84.8 uM for (6R)-N10-formyltetrahydrofolate (at pH 7.5) {ECO 0000269|PubMed 2185839}; Note=kcat is 20.7 sec(-1) for (6R)-N10-formyltetrahydrofolate (at pH 8.5). kcat is 13.5 sec(-1) for (6R)-N10- formyltetrahydrofolate (at pH 7.5). {ECO 0000269|PubMed 2185839}; pH dependence Optimum pH is 8.5. {ECO 0000269|PubMed 2185839}; # BioGrid 4261440 10 # CATALYTIC ACTIVITY PUR3_ECOLI 10-formyltetrahydrofolate + N(1)-(5-phospho-D- ribosyl)glycinamide = tetrahydrofolate + N(2)-formyl-N(1)-(5- phospho-D-ribosyl)glycinamide. {ECO 0000255|HAMAP-Rule MF_01930, ECO 0000269|PubMed 2185839, ECO 0000269|PubMed 350869}. # CDD cd08645 FMT_core_GART # ENZYME REGULATION Inhibited by N10-(bromoacetyl)-5,8- dideazafolate. {ECO:0000269|PubMed 2185839}. # EcoGene EG10799 purN # FUNCTION PUR3_ECOLI Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. {ECO 0000255|HAMAP-Rule MF_01930, ECO 0000269|PubMed 2185839, ECO 0000269|PubMed 350869}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004644 phosphoribosylglycinamide formyltransferase activity; IDA:EcoCyc. # GO_process GO:0006189 'de novo' IMP biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.170 -; 1. # HAMAP MF_01930 PurN # InterPro IPR001555 GART_AS # InterPro IPR002376 Formyl_transf_N # InterPro IPR004607 PurN # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00670 One carbon pool by folate # Organism PUR3_ECOLI Escherichia coli (strain K12) # PATHWAY PUR3_ECOLI Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5- phospho-D-ribosyl)glycinamide (10-formyl THF route) step 1/1. {ECO 0000255|HAMAP-Rule MF_01930, ECO 0000269|PubMed 8688421}. # PATRIC 32120389 VBIEscCol129921_2597 # PDB 1C2T X-ray; 2.10 A; A/B=1-212 # PDB 1C3E X-ray; 2.10 A; A/B=1-209 # PDB 1CDD X-ray; 2.80 A; A/B=1-212 # PDB 1CDE X-ray; 2.50 A; A/B/C/D=1-212 # PDB 1GAR X-ray; 1.96 A; A/B=1-212 # PDB 1GRC X-ray; 3.00 A; A/B=1-212 # PDB 1JKX X-ray; 1.60 A; A/B/C/D=1-212 # PDB 2GAR X-ray; 1.80 A; A=1-212 # PDB 3GAR X-ray; 1.90 A; A=1-212 # PIR A28486 XYECGF # PROSITE PS00373 GART # Pfam PF00551 Formyl_trans_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Phosphoribosylglycinamide formyltransferase {ECO:0000255|HAMAP-Rule MF_01930} # RefSeq NP_416995 NC_000913.3 # RefSeq WP_001028612 NZ_LN832404.1 # SIMILARITY Belongs to the GART family. {ECO:0000255|HAMAP- Rule MF_01930, ECO:0000305}. # SUBUNIT PUR3_ECOLI Monomer. Homodimer below pH 6.8. {ECO 0000269|PubMed 10606510, ECO 0000269|PubMed 1522592, ECO 0000269|PubMed 1631098, ECO 0000269|PubMed 2185839, ECO 0000269|PubMed 9698564}. # SUPFAM SSF53328 SSF53328 # TIGRFAMs TIGR00639 PurN # UniPathway UPA00074 UER00126 # eggNOG COG0299 LUCA # eggNOG ENOG4108V3E Bacteria BLAST swissprot:PUR3_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PUR3_ECOLI BioCyc ECOL316407:JW2485-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2485-MONOMER BioCyc EcoCyc:GART-MONOMER http://biocyc.org/getid?id=EcoCyc:GART-MONOMER BioCyc MetaCyc:GART-MONOMER http://biocyc.org/getid?id=MetaCyc:GART-MONOMER COG COG0299 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0299 DOI 10.1006/jmbi.1998.1931 http://dx.doi.org/10.1006/jmbi.1998.1931 DOI 10.1016/0022-2836(92)90698-J http://dx.doi.org/10.1016/0022-2836(92)90698-J DOI 10.1021/bi00458a014 http://dx.doi.org/10.1021/bi00458a014 DOI 10.1021/bi00480a018 http://dx.doi.org/10.1021/bi00480a018 DOI 10.1021/bi9528715 http://dx.doi.org/10.1021/bi9528715 DOI 10.1021/bi9904609 http://dx.doi.org/10.1021/bi9904609 DOI 10.1021/bi991888a http://dx.doi.org/10.1021/bi991888a DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.180094797 http://dx.doi.org/10.1073/pnas.180094797 DOI 10.1073/pnas.89.13.6114 http://dx.doi.org/10.1073/pnas.89.13.6114 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.2.2 {ECO:0000255|HAMAP-Rule:MF_01930, ECO:0000269|PubMed:2185839, ECO:0000269|PubMed:350869} http://www.genome.jp/dbget-bin/www_bget?EC:2.1.2.2 {ECO:0000255|HAMAP-Rule:MF_01930, ECO:0000269|PubMed:2185839, ECO:0000269|PubMed:350869} EMBL AF293167 http://www.ebi.ac.uk/ena/data/view/AF293167 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M13747 http://www.ebi.ac.uk/ena/data/view/M13747 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.1.2.2 {ECO:0000255|HAMAP-Rule:MF_01930, ECO:0000269|PubMed:2185839, ECO:0000269|PubMed:350869} http://enzyme.expasy.org/EC/2.1.2.2 {ECO:0000255|HAMAP-Rule:MF_01930, ECO:0000269|PubMed:2185839, ECO:0000269|PubMed:350869} EchoBASE EB0792 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0792 EcoGene EG10799 http://www.ecogene.org/geneInfo.php?eg_id=EG10799 EnsemblBacteria AAC75553 http://www.ensemblgenomes.org/id/AAC75553 EnsemblBacteria AAC75553 http://www.ensemblgenomes.org/id/AAC75553 EnsemblBacteria BAA16388 http://www.ensemblgenomes.org/id/BAA16388 EnsemblBacteria BAA16388 http://www.ensemblgenomes.org/id/BAA16388 EnsemblBacteria BAA16388 http://www.ensemblgenomes.org/id/BAA16388 EnsemblBacteria b2500 http://www.ensemblgenomes.org/id/b2500 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004644 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004644 GO_process GO:0006189 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006189 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.170 http://www.cathdb.info/version/latest/superfamily/3.40.50.170 GeneID 946973 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946973 HAMAP MF_01930 http://hamap.expasy.org/unirule/MF_01930 HOGENOM HOG000033575 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000033575&db=HOGENOM6 InParanoid P08179 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P08179 IntAct P08179 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P08179* IntEnz 2.1.2.2 {ECO:0000255|HAMAP-Rule:MF_01930, ECO:0000269|PubMed:2185839, ECO:0000269|PubMed:350869} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.2.2 {ECO:0000255|HAMAP-Rule:MF_01930, ECO:0000269|PubMed:2185839, ECO:0000269|PubMed:350869} InterPro IPR001555 http://www.ebi.ac.uk/interpro/entry/IPR001555 InterPro IPR002376 http://www.ebi.ac.uk/interpro/entry/IPR002376 InterPro IPR004607 http://www.ebi.ac.uk/interpro/entry/IPR004607 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2485 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2485 KEGG_Gene eco:b2500 http://www.genome.jp/dbget-bin/www_bget?eco:b2500 KEGG_Orthology KO:K11175 http://www.genome.jp/dbget-bin/www_bget?KO:K11175 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00670 http://www.genome.jp/kegg-bin/show_pathway?ko00670 KEGG_Reaction rn:R04325 http://www.genome.jp/dbget-bin/www_bget?rn:R04325 KEGG_Reaction rn:R04326 http://www.genome.jp/dbget-bin/www_bget?rn:R04326 OMA FKGTHTH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FKGTHTH PDB 1C2T http://www.ebi.ac.uk/pdbe-srv/view/entry/1C2T PDB 1C3E http://www.ebi.ac.uk/pdbe-srv/view/entry/1C3E PDB 1CDD http://www.ebi.ac.uk/pdbe-srv/view/entry/1CDD PDB 1CDE http://www.ebi.ac.uk/pdbe-srv/view/entry/1CDE PDB 1GAR http://www.ebi.ac.uk/pdbe-srv/view/entry/1GAR PDB 1GRC http://www.ebi.ac.uk/pdbe-srv/view/entry/1GRC PDB 1JKX http://www.ebi.ac.uk/pdbe-srv/view/entry/1JKX PDB 2GAR http://www.ebi.ac.uk/pdbe-srv/view/entry/2GAR PDB 3GAR http://www.ebi.ac.uk/pdbe-srv/view/entry/3GAR PDBsum 1C2T http://www.ebi.ac.uk/pdbsum/1C2T PDBsum 1C3E http://www.ebi.ac.uk/pdbsum/1C3E PDBsum 1CDD http://www.ebi.ac.uk/pdbsum/1CDD PDBsum 1CDE http://www.ebi.ac.uk/pdbsum/1CDE PDBsum 1GAR http://www.ebi.ac.uk/pdbsum/1GAR PDBsum 1GRC http://www.ebi.ac.uk/pdbsum/1GRC PDBsum 1JKX http://www.ebi.ac.uk/pdbsum/1JKX PDBsum 2GAR http://www.ebi.ac.uk/pdbsum/2GAR PDBsum 3GAR http://www.ebi.ac.uk/pdbsum/3GAR PROSITE PS00373 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00373 PSORT swissprot:PUR3_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PUR3_ECOLI PSORT-B swissprot:PUR3_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PUR3_ECOLI PSORT2 swissprot:PUR3_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PUR3_ECOLI Pfam PF00551 http://pfam.xfam.org/family/PF00551 Phobius swissprot:PUR3_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PUR3_ECOLI PhylomeDB P08179 http://phylomedb.org/?seqid=P08179 ProteinModelPortal P08179 http://www.proteinmodelportal.org/query/uniprot/P08179 PubMed 10433709 http://www.ncbi.nlm.nih.gov/pubmed/10433709 PubMed 10606510 http://www.ncbi.nlm.nih.gov/pubmed/10606510 PubMed 10954745 http://www.ncbi.nlm.nih.gov/pubmed/10954745 PubMed 1522592 http://www.ncbi.nlm.nih.gov/pubmed/1522592 PubMed 1631098 http://www.ncbi.nlm.nih.gov/pubmed/1631098 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2185839 http://www.ncbi.nlm.nih.gov/pubmed/2185839 PubMed 2204419 http://www.ncbi.nlm.nih.gov/pubmed/2204419 PubMed 3301838 http://www.ncbi.nlm.nih.gov/pubmed/3301838 PubMed 350869 http://www.ncbi.nlm.nih.gov/pubmed/350869 PubMed 8688421 http://www.ncbi.nlm.nih.gov/pubmed/8688421 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9698564 http://www.ncbi.nlm.nih.gov/pubmed/9698564 RefSeq NP_416995 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416995 RefSeq WP_001028612 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001028612 SMR P08179 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P08179 STRING 511145.b2500 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2500&targetmode=cogs STRING COG0299 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0299&targetmode=cogs SUPFAM SSF53328 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53328 TIGRFAMs TIGR00639 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00639 UniProtKB PUR3_ECOLI http://www.uniprot.org/uniprot/PUR3_ECOLI UniProtKB-AC P08179 http://www.uniprot.org/uniprot/P08179 charge swissprot:PUR3_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PUR3_ECOLI eggNOG COG0299 http://eggnogapi.embl.de/nog_data/html/tree/COG0299 eggNOG ENOG4108V3E http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108V3E epestfind swissprot:PUR3_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PUR3_ECOLI garnier swissprot:PUR3_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PUR3_ECOLI helixturnhelix swissprot:PUR3_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PUR3_ECOLI hmoment swissprot:PUR3_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PUR3_ECOLI iep swissprot:PUR3_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PUR3_ECOLI inforesidue swissprot:PUR3_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PUR3_ECOLI octanol swissprot:PUR3_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PUR3_ECOLI pepcoil swissprot:PUR3_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PUR3_ECOLI pepdigest swissprot:PUR3_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PUR3_ECOLI pepinfo swissprot:PUR3_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PUR3_ECOLI pepnet swissprot:PUR3_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PUR3_ECOLI pepstats swissprot:PUR3_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PUR3_ECOLI pepwheel swissprot:PUR3_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PUR3_ECOLI pepwindow swissprot:PUR3_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PUR3_ECOLI sigcleave swissprot:PUR3_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PUR3_ECOLI ## Database ID URL or Descriptions # AltName CTP molybdopterin cytidylyltransferase # AltName MOCA_ECOLI Mo-MPT cytidylyltransferase # AltName MOCA_ECOLI Molybdopterin cytidylyltransferase # AltName MOCA_ECOLI Molybdopterin-cytosine dinucleotide synthase # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=3.4 uM for CTP {ECO 0000269|PubMed:19542235}; # BioGrid 4259705 99 # CATALYTIC ACTIVITY CTP + molybdenum cofactor = diphosphate + cytidylyl molybdenum cofactor. {ECO:0000269|PubMed 19542235}. # COFACTOR MOCA_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 19542235}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 19542235}; Note=Mg(2+) is essential for activity. However, Mn(2+) is able to functionally replace Mg(2+) with a 50% reduced efficiency, whereas no MCD is produced with other divalent cations like Co(2+) or Ni(2+). {ECO 0000269|PubMed 19542235}; # DISRUPTION PHENOTYPE A disruption in the mocA gene impairs MCD biosynthesis in E.coli, resulting in an inactive PaoABC aldehyde oxidoreductase devoid of MCD cofactor. {ECO:0000269|PubMed 19542235}. # DOMAIN MOCA_ECOLI The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein. When the N-terminal domain of MobA is fused to the C-terminal domain of MocA, comparable kinetic constants as wild-type MobA are obtained with GTP, and the activity with CTP is completely lost. Consistent results are obtained when the N-terminal domain of MocA is fused to the C- terminal domain of MobA the kinetic constants with CTP are comparable with the ones found for wild-type MocA, although no activity with GTP is detected. {ECO 0000269|PubMed 21081498}. # EcoGene EG13060 mocA # FUNCTION MOCA_ECOLI Transfers a CMP moiety from CTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin cytosine dinucleotide (Mo-MCD) cofactor. Is specific for CTP; other nucleotides such as ATP and GTP cannot be utilized. Is also able to convert MPT to MCD in the absence of molybdate, however, with only one catalytic turnover. {ECO 0000269|PubMed 19542235}. # GO_function GO:0000166 nucleotide binding; IEA:UniProtKB-KW. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0061602 molybdenum cofactor cytidylyltransferase activity; IDA:EcoCyc. # GO_process GO:0006777 Mo-molybdopterin cofactor biosynthetic process; IMP:EcoCyc. # GO_process GO:1902760 Mo(VI)-molybdopterin cytosine dinucleotide biosynthetic process; IDA:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.90.550.10 -; 1. # IntAct Q46810 2 # InterPro IPR017696 Mo_hydrolase_YgfJ # InterPro IPR025877 MobA-like_NTP_Trfase # InterPro IPR029044 Nucleotide-diphossugar_trans # KEGG_Brite ko01000 Enzymes # Organism MOCA_ECOLI Escherichia coli (strain K12) # PATRIC 32121164 VBIEscCol129921_2970 # PIR E65071 E65071 # Pfam PF12804 NTP_transf_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MOCA_ECOLI Molybdenum cofactor cytidylyltransferase # RefSeq NP_417353 NC_000913.3 # RefSeq WP_001272828 NZ_LN832404.1 # SUBUNIT MOCA_ECOLI Monomer. Interacts with the Moco-binding chaperone PaoD. {ECO 0000269|PubMed 19542235, ECO 0000269|PubMed 21081498}. # SUPFAM SSF53448 SSF53448 # TIGRFAMs TIGR03310 matur_MocA_YgfJ # eggNOG COG2068 LUCA # eggNOG ENOG4105MFX Bacteria BLAST swissprot:MOCA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MOCA_ECOLI BioCyc ECOL316407:JW2845-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2845-MONOMER BioCyc EcoCyc:G7496-MONOMER http://biocyc.org/getid?id=EcoCyc:G7496-MONOMER BioCyc MetaCyc:G7496-MONOMER http://biocyc.org/getid?id=MetaCyc:G7496-MONOMER COG COG2068 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2068 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M109.008565 http://dx.doi.org/10.1074/jbc.M109.008565 DOI 10.1074/jbc.M110.155671 http://dx.doi.org/10.1074/jbc.M110.155671 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.7.76 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.76 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 ENZYME 2.7.7.76 http://enzyme.expasy.org/EC/2.7.7.76 EchoBASE EB2872 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2872 EcoGene EG13060 http://www.ecogene.org/geneInfo.php?eg_id=EG13060 EnsemblBacteria AAC75915 http://www.ensemblgenomes.org/id/AAC75915 EnsemblBacteria AAC75915 http://www.ensemblgenomes.org/id/AAC75915 EnsemblBacteria BAE76943 http://www.ensemblgenomes.org/id/BAE76943 EnsemblBacteria BAE76943 http://www.ensemblgenomes.org/id/BAE76943 EnsemblBacteria BAE76943 http://www.ensemblgenomes.org/id/BAE76943 EnsemblBacteria b2877 http://www.ensemblgenomes.org/id/b2877 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000166 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000166 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0061602 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061602 GO_process GO:0006777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006777 GO_process GO:1902760 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902760 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.90.550.10 http://www.cathdb.info/version/latest/superfamily/3.90.550.10 GeneID 947356 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947356 HOGENOM HOG000280424 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000280424&db=HOGENOM6 InParanoid Q46810 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46810 IntAct Q46810 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46810* IntEnz 2.7.7.76 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.76 InterPro IPR017696 http://www.ebi.ac.uk/interpro/entry/IPR017696 InterPro IPR025877 http://www.ebi.ac.uk/interpro/entry/IPR025877 InterPro IPR029044 http://www.ebi.ac.uk/interpro/entry/IPR029044 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2845 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2845 KEGG_Gene eco:b2877 http://www.genome.jp/dbget-bin/www_bget?eco:b2877 KEGG_Orthology KO:K07141 http://www.genome.jp/dbget-bin/www_bget?KO:K07141 OMA TEYCFLT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TEYCFLT PSORT swissprot:MOCA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MOCA_ECOLI PSORT-B swissprot:MOCA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MOCA_ECOLI PSORT2 swissprot:MOCA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MOCA_ECOLI Pfam PF12804 http://pfam.xfam.org/family/PF12804 Phobius swissprot:MOCA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MOCA_ECOLI PhylomeDB Q46810 http://phylomedb.org/?seqid=Q46810 ProteinModelPortal Q46810 http://www.proteinmodelportal.org/query/uniprot/Q46810 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19542235 http://www.ncbi.nlm.nih.gov/pubmed/19542235 PubMed 21081498 http://www.ncbi.nlm.nih.gov/pubmed/21081498 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417353 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417353 RefSeq WP_001272828 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001272828 STRING 511145.b2877 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2877&targetmode=cogs STRING COG2068 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2068&targetmode=cogs SUPFAM SSF53448 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53448 TIGRFAMs TIGR03310 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03310 UniProtKB MOCA_ECOLI http://www.uniprot.org/uniprot/MOCA_ECOLI UniProtKB-AC Q46810 http://www.uniprot.org/uniprot/Q46810 charge swissprot:MOCA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MOCA_ECOLI eggNOG COG2068 http://eggnogapi.embl.de/nog_data/html/tree/COG2068 eggNOG ENOG4105MFX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105MFX epestfind swissprot:MOCA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MOCA_ECOLI garnier swissprot:MOCA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MOCA_ECOLI helixturnhelix swissprot:MOCA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MOCA_ECOLI hmoment swissprot:MOCA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MOCA_ECOLI iep swissprot:MOCA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MOCA_ECOLI inforesidue swissprot:MOCA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MOCA_ECOLI octanol swissprot:MOCA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MOCA_ECOLI pepcoil swissprot:MOCA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MOCA_ECOLI pepdigest swissprot:MOCA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MOCA_ECOLI pepinfo swissprot:MOCA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MOCA_ECOLI pepnet swissprot:MOCA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MOCA_ECOLI pepstats swissprot:MOCA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MOCA_ECOLI pepwheel swissprot:MOCA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MOCA_ECOLI pepwindow swissprot:MOCA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MOCA_ECOLI sigcleave swissprot:MOCA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MOCA_ECOLI ## Database ID URL or Descriptions # AltName YAEF_ECOLI Uncharacterized lipoprotein YaeF # BioGrid 4261951 286 # EcoGene EG12138 yaeF # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_function GO:0008234 cysteine-type peptidase activity; IEA:UniProtKB-KW. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0008233 peptidase activity # InterPro IPR024453 Peptidase_C92 # Organism YAEF_ECOLI Escherichia coli (strain K12) # PATRIC 32115499 VBIEscCol129921_0201 # PIR A64744 A64744 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF05708 Peptidase_C92 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAEF_ECOLI Probable endopeptidase YaeF # RefSeq NP_414735 NC_000913.3 # RefSeq WP_001336393 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA82973.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAB08621.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=BAA08434.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; # SUBCELLULAR LOCATION YAEF_ECOLI Cell membrane {ECO 0000255|PROSITE- ProRule PRU00303}; Lipid-anchor {ECO 0000255|PROSITE- ProRule PRU00303}. # eggNOG ENOG4108UY0 Bacteria # eggNOG ENOG4111S0X LUCA BLAST swissprot:YAEF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAEF_ECOLI BioCyc ECOL316407:JW5016-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5016-MONOMER BioCyc EcoCyc:EG12138-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12138-MONOMER DOI 10.1038/347203a0 http://dx.doi.org/10.1038/347203a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.4.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D49445 http://www.ebi.ac.uk/ena/data/view/D49445 EMBL L38619 http://www.ebi.ac.uk/ena/data/view/L38619 EMBL M32357 http://www.ebi.ac.uk/ena/data/view/M32357 EMBL M97858 http://www.ebi.ac.uk/ena/data/view/M97858 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18345 http://www.ebi.ac.uk/ena/data/view/U18345 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 ENZYME 3.4.-.- http://enzyme.expasy.org/EC/3.4.-.- EchoBASE EB2059 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2059 EcoGene EG12138 http://www.ecogene.org/geneInfo.php?eg_id=EG12138 EnsemblBacteria AAC73304 http://www.ensemblgenomes.org/id/AAC73304 EnsemblBacteria AAC73304 http://www.ensemblgenomes.org/id/AAC73304 EnsemblBacteria BAA77869 http://www.ensemblgenomes.org/id/BAA77869 EnsemblBacteria BAA77869 http://www.ensemblgenomes.org/id/BAA77869 EnsemblBacteria BAA77869 http://www.ensemblgenomes.org/id/BAA77869 EnsemblBacteria b0193 http://www.ensemblgenomes.org/id/b0193 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0008234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008234 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GeneID 944892 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944892 HOGENOM HOG000116934 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000116934&db=HOGENOM6 InParanoid P37056 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37056 IntEnz 3.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4 InterPro IPR024453 http://www.ebi.ac.uk/interpro/entry/IPR024453 KEGG_Gene ecj:JW5016 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5016 KEGG_Gene eco:b0193 http://www.genome.jp/dbget-bin/www_bget?eco:b0193 OMA VATFKPE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VATFKPE PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YAEF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAEF_ECOLI PSORT-B swissprot:YAEF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAEF_ECOLI PSORT2 swissprot:YAEF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAEF_ECOLI Pfam PF05708 http://pfam.xfam.org/family/PF05708 Phobius swissprot:YAEF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAEF_ECOLI ProteinModelPortal P37056 http://www.proteinmodelportal.org/query/uniprot/P37056 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1688424 http://www.ncbi.nlm.nih.gov/pubmed/1688424 PubMed 2203971 http://www.ncbi.nlm.nih.gov/pubmed/2203971 PubMed 7635807 http://www.ncbi.nlm.nih.gov/pubmed/7635807 PubMed 7635808 http://www.ncbi.nlm.nih.gov/pubmed/7635808 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414735 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414735 RefSeq WP_001336393 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001336393 SMR P37056 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37056 STRING 511145.b0193 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0193&targetmode=cogs UniProtKB YAEF_ECOLI http://www.uniprot.org/uniprot/YAEF_ECOLI UniProtKB-AC P37056 http://www.uniprot.org/uniprot/P37056 charge swissprot:YAEF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAEF_ECOLI eggNOG ENOG4108UY0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UY0 eggNOG ENOG4111S0X http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111S0X epestfind swissprot:YAEF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAEF_ECOLI garnier swissprot:YAEF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAEF_ECOLI helixturnhelix swissprot:YAEF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAEF_ECOLI hmoment swissprot:YAEF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAEF_ECOLI iep swissprot:YAEF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAEF_ECOLI inforesidue swissprot:YAEF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAEF_ECOLI octanol swissprot:YAEF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAEF_ECOLI pepcoil swissprot:YAEF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAEF_ECOLI pepdigest swissprot:YAEF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAEF_ECOLI pepinfo swissprot:YAEF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAEF_ECOLI pepnet swissprot:YAEF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAEF_ECOLI pepstats swissprot:YAEF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAEF_ECOLI pepwheel swissprot:YAEF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAEF_ECOLI pepwindow swissprot:YAEF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAEF_ECOLI sigcleave swissprot:YAEF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAEF_ECOLI ## Database ID URL or Descriptions # BioGrid 4260912 12 # EcoGene EG14406 ldrD # FUNCTION LDRD_ECOLI Toxic peptide whose overexpression causes rapid cell killing and nucleoid condensation of the host cell. Overexpression induces stress-response and a number of membrane protein genes. {ECO 0000269|PubMed 12123448, ECO 0000269|PubMed 18710431}. # GO_process GO:0008219 cell death; IMP:EcoCyc. # GOslim_process GO:0008219 cell death # INDUCTION A type I toxin antitoxin (TA) system, where expression of the proteinaceous toxin is controlled by an antisense sRNA, in this case RdlD. Only a few of these TA systems have been mechanistically characterized; the mechanisms used to control expression of the toxin gene are not necessarily the same (Probable). {ECO 0000305}. # InterPro IPR025253 Toxin_Ldr # Organism LDRD_ECOLI Escherichia coli (strain K12) # PATRIC 48667006 VBIEscCol107702_3769 # Pfam PF13940 Ldr_toxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LDRD_ECOLI Small toxic polypeptide LdrD # RefSeq WP_000141634 NZ_LN832404.1 # RefSeq YP_026227 NC_000913.3 # SIMILARITY Belongs to the toxic peptide ldr family. {ECO 0000305}. BLAST swissprot:LDRD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LDRD_ECOLI BioCyc ECOL316407:JW5966-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5966-MONOMER BioCyc EcoCyc:MONOMER0-921 http://biocyc.org/getid?id=EcoCyc:MONOMER0-921 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2002.03042.x http://dx.doi.org/10.1046/j.1365-2958.2002.03042.x DOI 10.1111/j.1365-2958.2008.06394.x http://dx.doi.org/10.1111/j.1365-2958.2008.06394.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14406 http://www.ecogene.org/geneInfo.php?eg_id=EG14406 EnsemblBacteria AAT48189 http://www.ensemblgenomes.org/id/AAT48189 EnsemblBacteria AAT48189 http://www.ensemblgenomes.org/id/AAT48189 EnsemblBacteria BAE77756 http://www.ensemblgenomes.org/id/BAE77756 EnsemblBacteria BAE77756 http://www.ensemblgenomes.org/id/BAE77756 EnsemblBacteria BAE77756 http://www.ensemblgenomes.org/id/BAE77756 EnsemblBacteria b4453 http://www.ensemblgenomes.org/id/b4453 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0008219 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008219 GOslim_process GO:0008219 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008219 GeneID 2847730 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2847730 HOGENOM HOG000125979 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125979&db=HOGENOM6 InterPro IPR025253 http://www.ebi.ac.uk/interpro/entry/IPR025253 KEGG_Gene ecj:JW5966 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5966 KEGG_Gene eco:b4453 http://www.genome.jp/dbget-bin/www_bget?eco:b4453 PSORT swissprot:LDRD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LDRD_ECOLI PSORT-B swissprot:LDRD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LDRD_ECOLI PSORT2 swissprot:LDRD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LDRD_ECOLI Pfam PF13940 http://pfam.xfam.org/family/PF13940 Phobius swissprot:LDRD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LDRD_ECOLI PhylomeDB Q6BF25 http://phylomedb.org/?seqid=Q6BF25 ProteinModelPortal Q6BF25 http://www.proteinmodelportal.org/query/uniprot/Q6BF25 PubMed 12123448 http://www.ncbi.nlm.nih.gov/pubmed/12123448 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18710431 http://www.ncbi.nlm.nih.gov/pubmed/18710431 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000141634 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000141634 RefSeq YP_026227 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026227 STRING 511145.b4453 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4453&targetmode=cogs UniProtKB LDRD_ECOLI http://www.uniprot.org/uniprot/LDRD_ECOLI UniProtKB-AC Q6BF25 http://www.uniprot.org/uniprot/Q6BF25 charge swissprot:LDRD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LDRD_ECOLI epestfind swissprot:LDRD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LDRD_ECOLI garnier swissprot:LDRD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LDRD_ECOLI helixturnhelix swissprot:LDRD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LDRD_ECOLI hmoment swissprot:LDRD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LDRD_ECOLI iep swissprot:LDRD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LDRD_ECOLI inforesidue swissprot:LDRD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LDRD_ECOLI octanol swissprot:LDRD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LDRD_ECOLI pepcoil swissprot:LDRD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LDRD_ECOLI pepdigest swissprot:LDRD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LDRD_ECOLI pepinfo swissprot:LDRD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LDRD_ECOLI pepnet swissprot:LDRD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LDRD_ECOLI pepstats swissprot:LDRD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LDRD_ECOLI pepwheel swissprot:LDRD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LDRD_ECOLI pepwindow swissprot:LDRD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LDRD_ECOLI sigcleave swissprot:LDRD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LDRD_ECOLI ## Database ID URL or Descriptions # BioGrid 4262166 8 # CDD cd04235 AAK_CK # EcoGene EG13593 yahI # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008804 carbamate kinase activity; IBA:GO_Central. # GO_process GO:0019546 arginine deiminase pathway; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016301 kinase activity # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # Gene3D 3.40.1160.10 -; 1. # IntAct P77624 14 # InterPro IPR001048 Asp/Glu/Uridylate_kinase # InterPro IPR003964 Carb_kinase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00330 Arginine and proline metabolism # KEGG_Pathway ko00910 Nitrogen metabolism # Organism ARCM_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30409 PTHR30409 # PATRIC 32115775 VBIEscCol129921_0330 # PIR C64759 C64759 # PIRSF PIRSF000723 Carbamate_kin # Pfam PF00696 AA_kinase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ARCM_ECOLI Carbamate kinase-like protein YahI # RefSeq NP_414857 NC_000913.3 # RefSeq WP_000661672 NZ_LN832404.1 # SIMILARITY Belongs to the carbamate kinase family. {ECO 0000305}. # SUPFAM SSF53633 SSF53633 # eggNOG COG0549 LUCA # eggNOG ENOG4105C5B Bacteria BLAST swissprot:ARCM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARCM_ECOLI BioCyc ECOL316407:JW0315-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0315-MONOMER BioCyc EcoCyc:G6188-MONOMER http://biocyc.org/getid?id=EcoCyc:G6188-MONOMER COG COG0549 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0549 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB3362 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3362 EcoGene EG13593 http://www.ecogene.org/geneInfo.php?eg_id=EG13593 EnsemblBacteria AAC73426 http://www.ensemblgenomes.org/id/AAC73426 EnsemblBacteria AAC73426 http://www.ensemblgenomes.org/id/AAC73426 EnsemblBacteria BAE76106 http://www.ensemblgenomes.org/id/BAE76106 EnsemblBacteria BAE76106 http://www.ensemblgenomes.org/id/BAE76106 EnsemblBacteria BAE76106 http://www.ensemblgenomes.org/id/BAE76106 EnsemblBacteria b0323 http://www.ensemblgenomes.org/id/b0323 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008804 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008804 GO_process GO:0019546 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019546 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 3.40.1160.10 http://www.cathdb.info/version/latest/superfamily/3.40.1160.10 GeneID 944984 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944984 HOGENOM HOG000277403 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000277403&db=HOGENOM6 InParanoid P77624 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77624 IntAct P77624 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77624* InterPro IPR001048 http://www.ebi.ac.uk/interpro/entry/IPR001048 InterPro IPR003964 http://www.ebi.ac.uk/interpro/entry/IPR003964 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0315 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0315 KEGG_Gene eco:b0323 http://www.genome.jp/dbget-bin/www_bget?eco:b0323 KEGG_Orthology KO:K00926 http://www.genome.jp/dbget-bin/www_bget?KO:K00926 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00330 http://www.genome.jp/kegg-bin/show_pathway?ko00330 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Reaction rn:R00150 http://www.genome.jp/dbget-bin/www_bget?rn:R00150 KEGG_Reaction rn:R01395 http://www.genome.jp/dbget-bin/www_bget?rn:R01395 OMA DWHFVED http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DWHFVED PANTHER PTHR30409 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30409 PSORT swissprot:ARCM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARCM_ECOLI PSORT-B swissprot:ARCM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARCM_ECOLI PSORT2 swissprot:ARCM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARCM_ECOLI Pfam PF00696 http://pfam.xfam.org/family/PF00696 Phobius swissprot:ARCM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARCM_ECOLI PhylomeDB P77624 http://phylomedb.org/?seqid=P77624 ProteinModelPortal P77624 http://www.proteinmodelportal.org/query/uniprot/P77624 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414857 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414857 RefSeq WP_000661672 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000661672 SMR P77624 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77624 STRING 511145.b0323 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0323&targetmode=cogs STRING COG0549 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0549&targetmode=cogs SUPFAM SSF53633 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53633 UniProtKB ARCM_ECOLI http://www.uniprot.org/uniprot/ARCM_ECOLI UniProtKB-AC P77624 http://www.uniprot.org/uniprot/P77624 charge swissprot:ARCM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARCM_ECOLI eggNOG COG0549 http://eggnogapi.embl.de/nog_data/html/tree/COG0549 eggNOG ENOG4105C5B http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C5B epestfind swissprot:ARCM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARCM_ECOLI garnier swissprot:ARCM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARCM_ECOLI helixturnhelix swissprot:ARCM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARCM_ECOLI hmoment swissprot:ARCM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARCM_ECOLI iep swissprot:ARCM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARCM_ECOLI inforesidue swissprot:ARCM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARCM_ECOLI octanol swissprot:ARCM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARCM_ECOLI pepcoil swissprot:ARCM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARCM_ECOLI pepdigest swissprot:ARCM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARCM_ECOLI pepinfo swissprot:ARCM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARCM_ECOLI pepnet swissprot:ARCM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARCM_ECOLI pepstats swissprot:ARCM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARCM_ECOLI pepwheel swissprot:ARCM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARCM_ECOLI pepwindow swissprot:ARCM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARCM_ECOLI sigcleave swissprot:ARCM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARCM_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES GLDA_ECOLI Kinetic parameters KM=0.30 mM for dihydroxyacetone (at 25 degrees Celsius and pH 7) {ECO 0000269|PubMed 18179582}; KM=0.85 mM for glycolaldehyde (at 25 degrees Celsius and pH 7) {ECO 0000269|PubMed 18179582}; KM=0.50 mM for methylglyoxal (at 25 degrees Celsius and pH 7) {ECO 0000269|PubMed 18179582}; KM=56 mM for glycerol (at 25 degrees Celsius and pH 7) {ECO 0000269|PubMed 18179582}; Note=The catalytic efficiency of the reverse reaction (dihydroxyacetone reduction) is more than 100-fold higher than that of the forward direction (glycerol oxidation).; pH dependence Optimum pH is 5.5-6.0 for dihydroxyacetone reduction and 9.5- 10.0 for glycerol oxidation. {ECO 0000269|PubMed 40950}; # BioGrid 4262653 12 # CATALYTIC ACTIVITY Glycerol + NAD(+) = glycerone + NADH. {ECO:0000269|PubMed 18179582}. # COFACTOR GLDA_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000250}; Note=Binds 1 zinc ion per subunit. {ECO 0000250}; # DEVELOPMENTAL STAGE Expression is higher during stationary phase than during logarithmic growth. {ECO:0000269|PubMed 8132480}. # ENZYME REGULATION Inhibited by Cu(2+). {ECO:0000269|PubMed 40950}. # EcoGene EG11904 gldA # FUNCTION GLDA_ECOLI Catalyzes the NAD-dependent oxidation of glycerol to dihydroxyacetone (glycerone). Allows microorganisms to utilize glycerol as a source of carbon under anaerobic conditions. In E.coli, an important role of GldA is also likely to regulate the intracellular level of dihydroxyacetone by catalyzing the reverse reaction, i.e. the conversion of dihydroxyacetone into glycerol. Possesses a broad substrate specificity, since it is also able to oxidize 1,2-propanediol and to reduce glycolaldehyde, methylglyoxal and hydroxyacetone into ethylene glycol, lactaldehyde and 1,2-propanediol, respectively. {ECO 0000269|PubMed 18179582, ECO 0000269|PubMed 18632294, ECO 0000269|PubMed 40950, ECO 0000269|PubMed 8132480}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008888 glycerol dehydrogenase [NAD+] activity; IDA:EcoCyc. # GO_function GO:0019147 (R)-aminopropanol dehydrogenase activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0019588 anaerobic glycerol catabolic process; IMP:EcoCyc. # GO_process GO:0051596 methylglyoxal catabolic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # INDUCTION Full expression of gldA is achieved by induction with hydroxyacetone and stationary-phase growth conditions. {ECO:0000269|PubMed 8132480}. # InterPro IPR001670 ADH_Fe # InterPro IPR018211 ADH_Fe_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00561 Glycerolipid metabolism # Organism GLDA_ECOLI Escherichia coli (strain K12) # PATHWAY Polyol metabolism; glycerol fermentation; glycerone phosphate from glycerol (oxidative route) step 1/2. # PATRIC 32123413 VBIEscCol129921_4067 # PIR D65201 D65201 # PROSITE PS00060 ADH_IRON_2 # PROSITE PS00913 ADH_IRON_1 # Pfam PF00465 Fe-ADH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLDA_ECOLI Glycerol dehydrogenase # RefSeq NP_418380 NC_000913.3 # RefSeq WP_000374004 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAC43051.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the iron-containing alcohol dehydrogenase family. {ECO 0000305}. # SUBUNIT Homodimer and homooctamer. {ECO:0000269|PubMed 40950}. # UniPathway UPA00617 UER00668 # eggNOG COG0371 LUCA # eggNOG ENOG4105DCT Bacteria BLAST swissprot:GLDA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLDA_ECOLI BioCyc ECOL316407:JW5556-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5556-MONOMER BioCyc EcoCyc:GLYCDEH-MONOMER http://biocyc.org/getid?id=EcoCyc:GLYCDEH-MONOMER BioCyc MetaCyc:GLYCDEH-MONOMER http://biocyc.org/getid?id=MetaCyc:GLYCDEH-MONOMER COG COG0371 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0371 DIP DIP-47916N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47916N DOI 10.1016/j.ymben.2008.05.001 http://dx.doi.org/10.1016/j.ymben.2008.05.001 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1111/j.1574-6968.2007.01032.x http://dx.doi.org/10.1111/j.1574-6968.2007.01032.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1266/ggs.82.291 http://dx.doi.org/10.1266/ggs.82.291 EC_number EC:1.1.1.6 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.6 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.1.1.6 http://enzyme.expasy.org/EC/1.1.1.6 EchoBASE EB1849 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1849 EcoGene EG11904 http://www.ecogene.org/geneInfo.php?eg_id=EG11904 EnsemblBacteria AAC76927 http://www.ensemblgenomes.org/id/AAC76927 EnsemblBacteria AAC76927 http://www.ensemblgenomes.org/id/AAC76927 EnsemblBacteria BAE77365 http://www.ensemblgenomes.org/id/BAE77365 EnsemblBacteria BAE77365 http://www.ensemblgenomes.org/id/BAE77365 EnsemblBacteria BAE77365 http://www.ensemblgenomes.org/id/BAE77365 EnsemblBacteria b3945 http://www.ensemblgenomes.org/id/b3945 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008888 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008888 GO_function GO:0019147 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019147 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0019588 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019588 GO_process GO:0051596 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051596 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 948440 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948440 HOGENOM HOG000031784 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000031784&db=HOGENOM6 InParanoid P0A9S5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9S5 IntAct P0A9S5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9S5* IntEnz 1.1.1.6 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.6 InterPro IPR001670 http://www.ebi.ac.uk/interpro/entry/IPR001670 InterPro IPR018211 http://www.ebi.ac.uk/interpro/entry/IPR018211 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5556 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5556 KEGG_Gene eco:b3945 http://www.genome.jp/dbget-bin/www_bget?eco:b3945 KEGG_Orthology KO:K00005 http://www.genome.jp/dbget-bin/www_bget?KO:K00005 KEGG_Pathway ko00561 http://www.genome.jp/kegg-bin/show_pathway?ko00561 KEGG_Reaction rn:R01034 http://www.genome.jp/dbget-bin/www_bget?rn:R01034 OMA CERTLFA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CERTLFA PROSITE PS00060 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00060 PROSITE PS00913 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00913 PSORT swissprot:GLDA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLDA_ECOLI PSORT-B swissprot:GLDA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLDA_ECOLI PSORT2 swissprot:GLDA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLDA_ECOLI Pfam PF00465 http://pfam.xfam.org/family/PF00465 Phobius swissprot:GLDA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLDA_ECOLI PhylomeDB P0A9S5 http://phylomedb.org/?seqid=P0A9S5 ProteinModelPortal P0A9S5 http://www.proteinmodelportal.org/query/uniprot/P0A9S5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17895580 http://www.ncbi.nlm.nih.gov/pubmed/17895580 PubMed 18179582 http://www.ncbi.nlm.nih.gov/pubmed/18179582 PubMed 18632294 http://www.ncbi.nlm.nih.gov/pubmed/18632294 PubMed 40950 http://www.ncbi.nlm.nih.gov/pubmed/40950 PubMed 8132480 http://www.ncbi.nlm.nih.gov/pubmed/8132480 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418380 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418380 RefSeq WP_000374004 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000374004 SMR P0A9S5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9S5 STRING 511145.b3945 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3945&targetmode=cogs STRING COG0371 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0371&targetmode=cogs UniProtKB GLDA_ECOLI http://www.uniprot.org/uniprot/GLDA_ECOLI UniProtKB-AC P0A9S5 http://www.uniprot.org/uniprot/P0A9S5 charge swissprot:GLDA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLDA_ECOLI eggNOG COG0371 http://eggnogapi.embl.de/nog_data/html/tree/COG0371 eggNOG ENOG4105DCT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DCT epestfind swissprot:GLDA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLDA_ECOLI garnier swissprot:GLDA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLDA_ECOLI helixturnhelix swissprot:GLDA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLDA_ECOLI hmoment swissprot:GLDA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLDA_ECOLI iep swissprot:GLDA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLDA_ECOLI inforesidue swissprot:GLDA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLDA_ECOLI octanol swissprot:GLDA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLDA_ECOLI pepcoil swissprot:GLDA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLDA_ECOLI pepdigest swissprot:GLDA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLDA_ECOLI pepinfo swissprot:GLDA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLDA_ECOLI pepnet swissprot:GLDA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLDA_ECOLI pepstats swissprot:GLDA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLDA_ECOLI pepwheel swissprot:GLDA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLDA_ECOLI pepwindow swissprot:GLDA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLDA_ECOLI sigcleave swissprot:GLDA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLDA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261662 15 # EcoGene EG12948 yrhB # IntAct P46857 5 # InterPro IPR029082 Imm35 # Organism YRHB_ECOLI Escherichia coli (strain K12) # PATRIC 32122332 VBIEscCol129921_3543 # PIR A65141 A65141 # Pfam PF15567 Imm35 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YRHB_ECOLI Uncharacterized protein YrhB # RefSeq NP_417903 NC_000913.3 # RefSeq WP_000634159 NZ_LN832404.1 # eggNOG ENOG4106FA4 Bacteria # eggNOG ENOG410Y58G LUCA BLAST swissprot:YRHB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YRHB_ECOLI BioCyc ECOL316407:JW3411-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3411-MONOMER BioCyc EcoCyc:G7763-MONOMER http://biocyc.org/getid?id=EcoCyc:G7763-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2782 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2782 EcoGene EG12948 http://www.ecogene.org/geneInfo.php?eg_id=EG12948 EnsemblBacteria AAC76471 http://www.ensemblgenomes.org/id/AAC76471 EnsemblBacteria AAC76471 http://www.ensemblgenomes.org/id/AAC76471 EnsemblBacteria BAE77847 http://www.ensemblgenomes.org/id/BAE77847 EnsemblBacteria BAE77847 http://www.ensemblgenomes.org/id/BAE77847 EnsemblBacteria BAE77847 http://www.ensemblgenomes.org/id/BAE77847 EnsemblBacteria b3446 http://www.ensemblgenomes.org/id/b3446 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947948 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947948 HOGENOM HOG000125664 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125664&db=HOGENOM6 IntAct P46857 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P46857* InterPro IPR029082 http://www.ebi.ac.uk/interpro/entry/IPR029082 KEGG_Gene ecj:JW3411 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3411 KEGG_Gene eco:b3446 http://www.genome.jp/dbget-bin/www_bget?eco:b3446 PSORT swissprot:YRHB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YRHB_ECOLI PSORT-B swissprot:YRHB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YRHB_ECOLI PSORT2 swissprot:YRHB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YRHB_ECOLI Pfam PF15567 http://pfam.xfam.org/family/PF15567 Phobius swissprot:YRHB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YRHB_ECOLI ProteinModelPortal P46857 http://www.proteinmodelportal.org/query/uniprot/P46857 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417903 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417903 RefSeq WP_000634159 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000634159 STRING 511145.b3446 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3446&targetmode=cogs UniProtKB YRHB_ECOLI http://www.uniprot.org/uniprot/YRHB_ECOLI UniProtKB-AC P46857 http://www.uniprot.org/uniprot/P46857 charge swissprot:YRHB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YRHB_ECOLI eggNOG ENOG4106FA4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106FA4 eggNOG ENOG410Y58G http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y58G epestfind swissprot:YRHB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YRHB_ECOLI garnier swissprot:YRHB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YRHB_ECOLI helixturnhelix swissprot:YRHB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YRHB_ECOLI hmoment swissprot:YRHB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YRHB_ECOLI iep swissprot:YRHB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YRHB_ECOLI inforesidue swissprot:YRHB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YRHB_ECOLI octanol swissprot:YRHB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YRHB_ECOLI pepcoil swissprot:YRHB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YRHB_ECOLI pepdigest swissprot:YRHB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YRHB_ECOLI pepinfo swissprot:YRHB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YRHB_ECOLI pepnet swissprot:YRHB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YRHB_ECOLI pepstats swissprot:YRHB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YRHB_ECOLI pepwheel swissprot:YRHB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YRHB_ECOLI pepwindow swissprot:YRHB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YRHB_ECOLI sigcleave swissprot:YRHB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YRHB_ECOLI ## Database ID URL or Descriptions # BioGrid 4261514 3 # EcoGene EG13842 ynfD # InterPro IPR010595 DUF1161 # Organism YNFD_ECOLI Escherichia coli (strain K12) # PATRIC 32118474 VBIEscCol129921_1657 # PIR D64914 D64914 # Pfam PF06649 DUF1161 # ProDom PD336997 DUF1161 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNFD_ECOLI Uncharacterized protein YnfD # RefSeq NP_416103 NC_000913.3 # RefSeq WP_001300836 NZ_LN832404.1 # eggNOG ENOG4105KBG Bacteria # eggNOG ENOG41125YI LUCA BLAST swissprot:YNFD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNFD_ECOLI BioCyc ECOL316407:JW5259-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5259-MONOMER BioCyc EcoCyc:G6844-MONOMER http://biocyc.org/getid?id=EcoCyc:G6844-MONOMER DIP DIP-12764N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12764N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1574-6968.1998.tb13343.x http://dx.doi.org/10.1111/j.1574-6968.1998.tb13343.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3603 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3603 EcoGene EG13842 http://www.ecogene.org/geneInfo.php?eg_id=EG13842 EnsemblBacteria AAC74658 http://www.ensemblgenomes.org/id/AAC74658 EnsemblBacteria AAC74658 http://www.ensemblgenomes.org/id/AAC74658 EnsemblBacteria BAE76479 http://www.ensemblgenomes.org/id/BAE76479 EnsemblBacteria BAE76479 http://www.ensemblgenomes.org/id/BAE76479 EnsemblBacteria BAE76479 http://www.ensemblgenomes.org/id/BAE76479 EnsemblBacteria b1586 http://www.ensemblgenomes.org/id/b1586 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946133 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946133 HOGENOM HOG000120817 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120817&db=HOGENOM6 InParanoid P76172 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76172 IntAct P76172 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76172* InterPro IPR010595 http://www.ebi.ac.uk/interpro/entry/IPR010595 KEGG_Gene ecj:JW5259 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5259 KEGG_Gene eco:b1586 http://www.genome.jp/dbget-bin/www_bget?eco:b1586 OMA NIVPNDQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NIVPNDQ PSORT swissprot:YNFD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNFD_ECOLI PSORT-B swissprot:YNFD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNFD_ECOLI PSORT2 swissprot:YNFD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNFD_ECOLI Pfam PF06649 http://pfam.xfam.org/family/PF06649 Phobius swissprot:YNFD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNFD_ECOLI ProteinModelPortal P76172 http://www.proteinmodelportal.org/query/uniprot/P76172 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9868784 http://www.ncbi.nlm.nih.gov/pubmed/9868784 RefSeq NP_416103 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416103 RefSeq WP_001300836 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300836 STRING 511145.b1586 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1586&targetmode=cogs UniProtKB YNFD_ECOLI http://www.uniprot.org/uniprot/YNFD_ECOLI UniProtKB-AC P76172 http://www.uniprot.org/uniprot/P76172 charge swissprot:YNFD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNFD_ECOLI eggNOG ENOG4105KBG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KBG eggNOG ENOG41125YI http://eggnogapi.embl.de/nog_data/html/tree/ENOG41125YI epestfind swissprot:YNFD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNFD_ECOLI garnier swissprot:YNFD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNFD_ECOLI helixturnhelix swissprot:YNFD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNFD_ECOLI hmoment swissprot:YNFD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNFD_ECOLI iep swissprot:YNFD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNFD_ECOLI inforesidue swissprot:YNFD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNFD_ECOLI octanol swissprot:YNFD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNFD_ECOLI pepcoil swissprot:YNFD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNFD_ECOLI pepdigest swissprot:YNFD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNFD_ECOLI pepinfo swissprot:YNFD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNFD_ECOLI pepnet swissprot:YNFD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNFD_ECOLI pepstats swissprot:YNFD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNFD_ECOLI pepwheel swissprot:YNFD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNFD_ECOLI pepwindow swissprot:YNFD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNFD_ECOLI sigcleave swissprot:YNFD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNFD_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES MAZG_ECOLI Kinetic parameters KM=0.34 mM for dATP (at pH 9.6 and at 37 degrees Celsius in the presence of 5 mM magnesium) {ECO 0000269|PubMed 20529853}; KM=0.71 mM for UTP (at pH 9.6 and at 37 degrees Celsius in the presence of 5 mM magnesium) {ECO 0000269|PubMed 20529853}; KM=0.36 mM for 8-oxo-dGTP (at pH 9.6 and at 37 degrees Celsius in the presence of 5 mM magnesium) {ECO 0000269|PubMed 20529853}; Vmax=0.23 nmol/min/ug enzyme for 8-oxo-dGTP (at pH 9.6 and at 37 degrees Celsius in the presence of 5 mM magnesium) {ECO 0000269|PubMed 20529853}; Vmax=1.9 nmol/min/ug enzyme for dATP (at pH 9.6 and at 37 degrees Celsius in the presence of 5 mM magnesium) {ECO 0000269|PubMed 20529853}; Vmax=1.9 nmol/min/ug enzyme for dUTP (at pH 9.6 and at 37 degrees Celsius in the presence of 5 mM magnesium) {ECO 0000269|PubMed 20529853}; # BioGrid 4262299 19 # CATALYTIC ACTIVITY MAZG_ECOLI ATP + H(2)O = AMP + diphosphate. {ECO 0000269|PubMed 12218018, ECO 0000269|PubMed 18353782}. # COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI 18420; # ENZYME REGULATION Inhibited by the MazE-MazF complex. {ECO:0000269|PubMed 16390452}. # EcoGene EG10572 mazG # FUNCTION MAZG_ECOLI Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazE-MazF toxin-antitoxin (TA) module that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp produced by RelA under amino acid starvation, thus protecting the cell from the toxicity of MazF. Reduction of (p)ppGpp can be achieved by direct degradation of (p)ppGpp or by degradation of NTPs, which are substrates for (p)ppGpp synthesis by RelA. {ECO 0000269|PubMed 16390452, ECO 0000269|PubMed 18353782, ECO 0000269|PubMed 20529853}. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0047429 nucleoside-triphosphate diphosphatase activity; IDA:EcoCyc. # GO_function GO:0047693 ATP diphosphatase activity; IEA:UniProtKB-EC. # GO_process GO:0006203 dGTP catabolic process; IBA:GO_Central. # GO_process GO:0009267 cellular response to starvation; IMP:EcoCyc. # GO_process GO:0046047 TTP catabolic process; IBA:GO_Central. # GO_process GO:0046052 UTP catabolic process; IBA:GO_Central. # GO_process GO:0046061 dATP catabolic process; IBA:GO_Central. # GO_process GO:0046076 dTTP catabolic process; IBA:GO_Central. # GO_process GO:0046081 dUTP catabolic process; IBA:GO_Central. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # GOslim_process GO:0044281 small molecule metabolic process # INDUCTION MAZG_ECOLI Part of the relA-mazE-mazF-mazG operon, there is also a second mazE-mazF specific promoter which is negatively autoregulated. # IntAct P0AEY3 7 # InterPro IPR004518 MazG_cat # InterPro IPR011551 NTP_PyrPHydrolase_MazG # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00240 Pyrimidine metabolism # Organism MAZG_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30522:SF0 PTHR30522:SF0 # PATRIC 32120978 VBIEscCol129921_2881 # PDB 3CRA X-ray; 2.10 A; A/B=1-263 # PDB 3CRC X-ray; 3.00 A; A/B=1-263 # PIR A65060 A65060 # Pfam PF03819 MazG; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MAZG_ECOLI Nucleoside triphosphate pyrophosphohydrolase # RefSeq NP_417261 NC_000913.3 # RefSeq WP_001071648 NZ_LN832404.1 # SIMILARITY Belongs to the nucleoside triphosphate pyrophosphohydrolase family. {ECO 0000305}. # SUBUNIT MAZG_ECOLI Homodimer. Interacts with Era. {ECO 0000269|PubMed 12218018, ECO 0000269|PubMed 18353782}. # TIGRFAMs TIGR00444 mazG # eggNOG COG1694 LUCA # eggNOG ENOG4105DXN Bacteria BLAST swissprot:MAZG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MAZG_ECOLI BioCyc ECOL316407:JW2752-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2752-MONOMER BioCyc EcoCyc:EG10572-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10572-MONOMER BioCyc MetaCyc:EG10572-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10572-MONOMER COG COG1694 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1694 DIP DIP-48054N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48054N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M109.088872 http://dx.doi.org/10.1074/jbc.M109.088872 DOI 10.1074/jbc.M800479200 http://dx.doi.org/10.1074/jbc.M800479200 DOI 10.1111/j.1365-2958.2005.04956.x http://dx.doi.org/10.1111/j.1365-2958.2005.04956.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.19.5323-5329.2002 http://dx.doi.org/10.1128/JB.184.19.5323-5329.2002 EC_number EC:3.6.1.8 http://www.genome.jp/dbget-bin/www_bget?EC:3.6.1.8 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J04039 http://www.ebi.ac.uk/ena/data/view/J04039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29580 http://www.ebi.ac.uk/ena/data/view/U29580 ENZYME 3.6.1.8 http://enzyme.expasy.org/EC/3.6.1.8 EchoBASE EB0567 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0567 EcoGene EG10572 http://www.ecogene.org/geneInfo.php?eg_id=EG10572 EnsemblBacteria AAC75823 http://www.ensemblgenomes.org/id/AAC75823 EnsemblBacteria AAC75823 http://www.ensemblgenomes.org/id/AAC75823 EnsemblBacteria BAE76855 http://www.ensemblgenomes.org/id/BAE76855 EnsemblBacteria BAE76855 http://www.ensemblgenomes.org/id/BAE76855 EnsemblBacteria BAE76855 http://www.ensemblgenomes.org/id/BAE76855 EnsemblBacteria b2781 http://www.ensemblgenomes.org/id/b2781 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0047429 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047429 GO_function GO:0047693 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047693 GO_process GO:0006203 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006203 GO_process GO:0009267 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009267 GO_process GO:0046047 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046047 GO_process GO:0046052 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046052 GO_process GO:0046061 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046061 GO_process GO:0046076 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046076 GO_process GO:0046081 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046081 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 947254 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947254 HOGENOM HOG000272340 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000272340&db=HOGENOM6 InParanoid P0AEY3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEY3 IntAct P0AEY3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEY3* IntEnz 3.6.1.8 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.1.8 InterPro IPR004518 http://www.ebi.ac.uk/interpro/entry/IPR004518 InterPro IPR011551 http://www.ebi.ac.uk/interpro/entry/IPR011551 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2752 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2752 KEGG_Gene eco:b2781 http://www.genome.jp/dbget-bin/www_bget?eco:b2781 KEGG_Orthology KO:K04765 http://www.genome.jp/dbget-bin/www_bget?KO:K04765 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Reaction rn:R00086 http://www.genome.jp/dbget-bin/www_bget?rn:R00086 KEGG_Reaction rn:R00087 http://www.genome.jp/dbget-bin/www_bget?rn:R00087 KEGG_Reaction rn:R00287 http://www.genome.jp/dbget-bin/www_bget?rn:R00287 KEGG_Reaction rn:R00426 http://www.genome.jp/dbget-bin/www_bget?rn:R00426 KEGG_Reaction rn:R00515 http://www.genome.jp/dbget-bin/www_bget?rn:R00515 KEGG_Reaction rn:R00662 http://www.genome.jp/dbget-bin/www_bget?rn:R00662 KEGG_Reaction rn:R00720 http://www.genome.jp/dbget-bin/www_bget?rn:R00720 MINT MINT-1311211 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1311211 OMA RVGFDWE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RVGFDWE PANTHER PTHR30522:SF0 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30522:SF0 PDB 3CRA http://www.ebi.ac.uk/pdbe-srv/view/entry/3CRA PDB 3CRC http://www.ebi.ac.uk/pdbe-srv/view/entry/3CRC PDBsum 3CRA http://www.ebi.ac.uk/pdbsum/3CRA PDBsum 3CRC http://www.ebi.ac.uk/pdbsum/3CRC PSORT swissprot:MAZG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MAZG_ECOLI PSORT-B swissprot:MAZG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MAZG_ECOLI PSORT2 swissprot:MAZG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MAZG_ECOLI Pfam PF03819 http://pfam.xfam.org/family/PF03819 Phobius swissprot:MAZG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MAZG_ECOLI PhylomeDB P0AEY3 http://phylomedb.org/?seqid=P0AEY3 ProteinModelPortal P0AEY3 http://www.proteinmodelportal.org/query/uniprot/P0AEY3 PubMed 12218018 http://www.ncbi.nlm.nih.gov/pubmed/12218018 PubMed 16390452 http://www.ncbi.nlm.nih.gov/pubmed/16390452 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18353782 http://www.ncbi.nlm.nih.gov/pubmed/18353782 PubMed 20529853 http://www.ncbi.nlm.nih.gov/pubmed/20529853 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417261 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417261 RefSeq WP_001071648 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001071648 SMR P0AEY3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEY3 STRING 511145.b2781 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2781&targetmode=cogs STRING COG1694 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1694&targetmode=cogs TIGRFAMs TIGR00444 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00444 UniProtKB MAZG_ECOLI http://www.uniprot.org/uniprot/MAZG_ECOLI UniProtKB-AC P0AEY3 http://www.uniprot.org/uniprot/P0AEY3 charge swissprot:MAZG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MAZG_ECOLI eggNOG COG1694 http://eggnogapi.embl.de/nog_data/html/tree/COG1694 eggNOG ENOG4105DXN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DXN epestfind swissprot:MAZG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MAZG_ECOLI garnier swissprot:MAZG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MAZG_ECOLI helixturnhelix swissprot:MAZG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MAZG_ECOLI hmoment swissprot:MAZG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MAZG_ECOLI iep swissprot:MAZG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MAZG_ECOLI inforesidue swissprot:MAZG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MAZG_ECOLI octanol swissprot:MAZG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MAZG_ECOLI pepcoil swissprot:MAZG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MAZG_ECOLI pepdigest swissprot:MAZG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MAZG_ECOLI pepinfo swissprot:MAZG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MAZG_ECOLI pepnet swissprot:MAZG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MAZG_ECOLI pepstats swissprot:MAZG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MAZG_ECOLI pepwheel swissprot:MAZG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MAZG_ECOLI pepwindow swissprot:MAZG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MAZG_ECOLI sigcleave swissprot:MAZG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MAZG_ECOLI ## Database ID URL or Descriptions # BioGrid 4262112 119 # EcoGene EG13710 elfD # FUNCTION ELFD_ECOLI Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the ElfA fimbriae. {ECO 0000269|PubMed 20345943}. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IEA:InterPro. # GO_function GO:0044183 protein binding involved in protein folding; IBA:GO_Central. # GO_process GO:0043711 pilus organization; IMP:EcoCyc. # GO_process GO:0061077 chaperone-mediated protein folding; IBA:GO_Central. # GO_process GO:0071555 cell wall organization; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006457 protein folding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 2.60.40.1070 -; 1. # Gene3D 2.60.40.360 -; 1. # INDUCTION Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression. {ECO:0000269|PubMed 20345943}. # IntAct P75856 3 # InterPro IPR001829 Pili_assmbl_chaperone_bac # InterPro IPR008962 PapD-like # InterPro IPR016147 Pili_assmbl_chaperone_N # InterPro IPR016148 Pili_assmbl_chaperone_C # InterPro IPR018046 Pili_assmbl_chaperone_CS # MISCELLANEOUS The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed. {ECO:0000305|PubMed 20345943}. # Organism ELFD_ECOLI Escherichia coli (strain K12) # PATRIC 32117097 VBIEscCol129921_0973 # PIR B64834 B64834 # PRINTS PR00969 CHAPERONPILI # PROSITE PS00635 PILI_CHAPERONE # Pfam PF00345 PapD_N # Pfam PF02753 PapD_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ELFD_ECOLI Probable fimbrial chaperone protein ElfD # RefSeq NP_415459 NC_000913.3 # SIMILARITY Belongs to the periplasmic pilus chaperone family. {ECO 0000305}. # SIMILARITY Contains 1 Ig-like (immunoglobulin-like) domain. {ECO 0000305}. # SUBCELLULAR LOCATION ELFD_ECOLI Periplasm {ECO 0000250}. # SUPFAM SSF49354 SSF49354 # SUPFAM SSF49584 SSF49584 # eggNOG COG3121 LUCA # eggNOG ENOG4106JJN Bacteria BLAST swissprot:ELFD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ELFD_ECOLI BioCyc ECOL316407:JW0922-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0922-MONOMER BioCyc EcoCyc:G6481-MONOMER http://biocyc.org/getid?id=EcoCyc:G6481-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1462-2920.2010.02202.x http://dx.doi.org/10.1111/j.1462-2920.2010.02202.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3474 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3474 EcoGene EG13710 http://www.ecogene.org/geneInfo.php?eg_id=EG13710 EnsemblBacteria AAC74025 http://www.ensemblgenomes.org/id/AAC74025 EnsemblBacteria AAC74025 http://www.ensemblgenomes.org/id/AAC74025 EnsemblBacteria BAA35694 http://www.ensemblgenomes.org/id/BAA35694 EnsemblBacteria BAA35694 http://www.ensemblgenomes.org/id/BAA35694 EnsemblBacteria BAA35694 http://www.ensemblgenomes.org/id/BAA35694 EnsemblBacteria b0939 http://www.ensemblgenomes.org/id/b0939 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0044183 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044183 GO_process GO:0043711 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043711 GO_process GO:0061077 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061077 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 2.60.40.1070 http://www.cathdb.info/version/latest/superfamily/2.60.40.1070 Gene3D 2.60.40.360 http://www.cathdb.info/version/latest/superfamily/2.60.40.360 GeneID 946773 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946773 HOGENOM HOG000260152 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260152&db=HOGENOM6 IntAct P75856 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75856* InterPro IPR001829 http://www.ebi.ac.uk/interpro/entry/IPR001829 InterPro IPR008962 http://www.ebi.ac.uk/interpro/entry/IPR008962 InterPro IPR016147 http://www.ebi.ac.uk/interpro/entry/IPR016147 InterPro IPR016148 http://www.ebi.ac.uk/interpro/entry/IPR016148 InterPro IPR018046 http://www.ebi.ac.uk/interpro/entry/IPR018046 KEGG_Gene ecj:JW0922 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0922 KEGG_Gene eco:b0939 http://www.genome.jp/dbget-bin/www_bget?eco:b0939 OMA MGAKNSS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MGAKNSS PRINTS PR00969 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00969 PROSITE PS00635 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00635 PSORT swissprot:ELFD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ELFD_ECOLI PSORT-B swissprot:ELFD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ELFD_ECOLI PSORT2 swissprot:ELFD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ELFD_ECOLI Pfam PF00345 http://pfam.xfam.org/family/PF00345 Pfam PF02753 http://pfam.xfam.org/family/PF02753 Phobius swissprot:ELFD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ELFD_ECOLI PhylomeDB P75856 http://phylomedb.org/?seqid=P75856 ProteinModelPortal P75856 http://www.proteinmodelportal.org/query/uniprot/P75856 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20345943 http://www.ncbi.nlm.nih.gov/pubmed/20345943 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415459 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415459 STRING 511145.b0939 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0939&targetmode=cogs SUPFAM SSF49354 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49354 SUPFAM SSF49584 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49584 UniProtKB ELFD_ECOLI http://www.uniprot.org/uniprot/ELFD_ECOLI UniProtKB-AC P75856 http://www.uniprot.org/uniprot/P75856 charge swissprot:ELFD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ELFD_ECOLI eggNOG COG3121 http://eggnogapi.embl.de/nog_data/html/tree/COG3121 eggNOG ENOG4106JJN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106JJN epestfind swissprot:ELFD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ELFD_ECOLI garnier swissprot:ELFD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ELFD_ECOLI helixturnhelix swissprot:ELFD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ELFD_ECOLI hmoment swissprot:ELFD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ELFD_ECOLI iep swissprot:ELFD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ELFD_ECOLI inforesidue swissprot:ELFD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ELFD_ECOLI octanol swissprot:ELFD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ELFD_ECOLI pepcoil swissprot:ELFD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ELFD_ECOLI pepdigest swissprot:ELFD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ELFD_ECOLI pepinfo swissprot:ELFD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ELFD_ECOLI pepnet swissprot:ELFD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ELFD_ECOLI pepstats swissprot:ELFD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ELFD_ECOLI pepwheel swissprot:ELFD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ELFD_ECOLI pepwindow swissprot:ELFD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ELFD_ECOLI sigcleave swissprot:ELFD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ELFD_ECOLI ## Database ID URL or Descriptions # BioGrid 4262506 8 # CATALYTIC ACTIVITY OPDA_ECOLI Hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-|-Gly-Pro-Ala is cleaved, but not Z-(Gly)(5). # COFACTOR OPDA_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000250}; Note=Binds 1 zinc ion. {ECO 0000250}; # EcoGene EG11441 prlC # FUNCTION OPDA_ECOLI May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4). # GO_component GO:0005737 cytoplasm; TAS:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004222 metalloendopeptidase activity; IBA:GO_Central. # GO_function GO:0008233 peptidase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006260 DNA replication; TAS:EcoCyc. # GO_process GO:0006465 signal peptide processing; IDA:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0051604 protein maturation # Gene3D 1.10.1370.10 -; 2. # Gene3D 1.20.1050.40 -; 1. # Gene3D 3.40.390.10 -; 1. # IntAct P27298 4 # InterPro IPR001567 Pept_M3A_M3B # InterPro IPR024077 Neurolysin/TOP_dom2 # InterPro IPR024079 MetalloPept_cat_dom # InterPro IPR024080 Neurolysin/TOP_N # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # Organism OPDA_ECOLI Escherichia coli (strain K12) # PATRIC 32122446 VBIEscCol129921_3600 # PIR S47718 S47718 # PROSITE PS00142 ZINC_PROTEASE # Pfam PF01432 Peptidase_M3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName OPDA_ECOLI Oligopeptidase A # RefSeq NP_417955 NC_000913.3 # RefSeq WP_001298719 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase M3 family. {ECO 0000305}. # eggNOG COG0339 LUCA # eggNOG ENOG4105DGW Bacteria BLAST swissprot:OPDA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:OPDA_ECOLI BioCyc ECOL316407:JW3465-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3465-MONOMER BioCyc EcoCyc:EG11441-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11441-MONOMER BioCyc MetaCyc:EG11441-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11441-MONOMER COG COG0339 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0339 DIP DIP-10566N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10566N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.24.70 http://www.genome.jp/dbget-bin/www_bget?EC:3.4.24.70 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M93984 http://www.ebi.ac.uk/ena/data/view/M93984 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.4.24.70 http://enzyme.expasy.org/EC/3.4.24.70 EchoBASE EB1411 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1411 EcoGene EG11441 http://www.ecogene.org/geneInfo.php?eg_id=EG11441 EnsemblBacteria AAC76523 http://www.ensemblgenomes.org/id/AAC76523 EnsemblBacteria AAC76523 http://www.ensemblgenomes.org/id/AAC76523 EnsemblBacteria BAE77796 http://www.ensemblgenomes.org/id/BAE77796 EnsemblBacteria BAE77796 http://www.ensemblgenomes.org/id/BAE77796 EnsemblBacteria BAE77796 http://www.ensemblgenomes.org/id/BAE77796 EnsemblBacteria b3498 http://www.ensemblgenomes.org/id/b3498 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004222 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004222 GO_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260 GO_process GO:0006465 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006465 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 Gene3D 1.10.1370.10 http://www.cathdb.info/version/latest/superfamily/1.10.1370.10 Gene3D 1.20.1050.40 http://www.cathdb.info/version/latest/superfamily/1.20.1050.40 Gene3D 3.40.390.10 http://www.cathdb.info/version/latest/superfamily/3.40.390.10 GeneID 948016 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948016 HOGENOM HOG000245986 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000245986&db=HOGENOM6 InParanoid P27298 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P27298 IntAct P27298 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P27298* IntEnz 3.4.24.70 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.24.70 InterPro IPR001567 http://www.ebi.ac.uk/interpro/entry/IPR001567 InterPro IPR024077 http://www.ebi.ac.uk/interpro/entry/IPR024077 InterPro IPR024079 http://www.ebi.ac.uk/interpro/entry/IPR024079 InterPro IPR024080 http://www.ebi.ac.uk/interpro/entry/IPR024080 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW3465 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3465 KEGG_Gene eco:b3498 http://www.genome.jp/dbget-bin/www_bget?eco:b3498 KEGG_Orthology KO:K01414 http://www.genome.jp/dbget-bin/www_bget?KO:K01414 MINT MINT-1234260 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1234260 OMA VMRPPAY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VMRPPAY PROSITE PS00142 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00142 PSORT swissprot:OPDA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:OPDA_ECOLI PSORT-B swissprot:OPDA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:OPDA_ECOLI PSORT2 swissprot:OPDA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:OPDA_ECOLI Pfam PF01432 http://pfam.xfam.org/family/PF01432 Phobius swissprot:OPDA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:OPDA_ECOLI PhylomeDB P27298 http://phylomedb.org/?seqid=P27298 ProteinModelPortal P27298 http://www.proteinmodelportal.org/query/uniprot/P27298 PubMed 1325967 http://www.ncbi.nlm.nih.gov/pubmed/1325967 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 8366062 http://www.ncbi.nlm.nih.gov/pubmed/8366062 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417955 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417955 RefSeq WP_001298719 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001298719 SMR P27298 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P27298 STRING 511145.b3498 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3498&targetmode=cogs STRING COG0339 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0339&targetmode=cogs UniProtKB OPDA_ECOLI http://www.uniprot.org/uniprot/OPDA_ECOLI UniProtKB-AC P27298 http://www.uniprot.org/uniprot/P27298 charge swissprot:OPDA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:OPDA_ECOLI eggNOG COG0339 http://eggnogapi.embl.de/nog_data/html/tree/COG0339 eggNOG ENOG4105DGW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DGW epestfind swissprot:OPDA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:OPDA_ECOLI garnier swissprot:OPDA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:OPDA_ECOLI helixturnhelix swissprot:OPDA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:OPDA_ECOLI hmoment swissprot:OPDA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:OPDA_ECOLI iep swissprot:OPDA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:OPDA_ECOLI inforesidue swissprot:OPDA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:OPDA_ECOLI octanol swissprot:OPDA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:OPDA_ECOLI pepcoil swissprot:OPDA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:OPDA_ECOLI pepdigest swissprot:OPDA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:OPDA_ECOLI pepinfo swissprot:OPDA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:OPDA_ECOLI pepnet swissprot:OPDA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:OPDA_ECOLI pepstats swissprot:OPDA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:OPDA_ECOLI pepwheel swissprot:OPDA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:OPDA_ECOLI pepwindow swissprot:OPDA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:OPDA_ECOLI sigcleave swissprot:OPDA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:OPDA_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES LHGO_ECOLI Kinetic parameters KM=95 uM for L-2-hydroxyglutarate {ECO 0000269|PubMed 18390652}; Vmax=113 nmol/min/mg enzyme {ECO 0000269|PubMed 18390652}; # BioGrid 4263106 8 # CATALYTIC ACTIVITY LHGO_ECOLI (S)-2-hydroxy acid + O(2) = 2-oxo acid + H(2)O(2). {ECO 0000255|HAMAP-Rule MF_00990, ECO 0000269|PubMed 18390652}. # COFACTOR LHGO_ECOLI Name=FAD; Xref=ChEBI CHEBI 57692; Evidence={ECO 0000255|HAMAP-Rule MF_00990, ECO 0000269|PubMed 18390652}; # EcoGene EG12387 lhgO # FUNCTION LHGO_ECOLI Oxidizes L-2-hydroxyglutarate, probably to recover alpha-ketoglutarate mistakenly reduced by other enzymes or formed during growth on propionate. {ECO 0000255|HAMAP-Rule MF_00990, ECO 0000269|PubMed 18390652}. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_function GO:0034419 L-2-hydroxyglutarate oxidase activity; IDA:EcoCyc. # GO_function GO:0050660 flavin adenine dinucleotide binding; IDA:EcoCyc. # GO_function GO:0052852 very-long-chain-(S)-2-hydroxy-acid oxidase activity; IEA:UniProtKB-EC. # GO_function GO:0052853 long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity; IEA:UniProtKB-EC. # GO_function GO:0052854 medium-chain-(S)-2-hydroxy-acid oxidase activity; IEA:UniProtKB-EC. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # Gene3D 3.50.50.60 -; 2. # HAMAP MF_00990 L_hydroxyglutarate_oxidase # INDUCTION Expression is induced by RpoS during carbon starvation and at stationary phase. Is also regulated by cAMP-CRP. Repressed by CsiR. {ECO:0000269|PubMed 14731280}. # IntAct P37339 4 # InterPro IPR006076 FAD-dep_OxRdtase # InterPro IPR023753 FAD/NAD-binding_dom # InterPro IPR030862 L_hydroxyglutarate_Oxase # KEGG_Brite ko01000 Enzymes # Organism LHGO_ECOLI Escherichia coli (strain K12) # PATRIC 32120710 VBIEscCol129921_2752 # PIR E65045 E65045 # Pfam PF01266 DAO # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName L-2-hydroxyglutarate oxidase LhgO {ECO:0000255|HAMAP-Rule MF_00990} # RefSeq NP_417146 NC_000913.3 # RefSeq WP_000271909 NZ_LN832404.1 # SIMILARITY Belongs to the L2HGDH family. {ECO:0000255|HAMAP- Rule MF_00990}. # SUPFAM SSF51905 SSF51905 # eggNOG COG0579 LUCA # eggNOG ENOG4105D5U Bacteria BLAST swissprot:LHGO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LHGO_ECOLI BioCyc ECOL316407:JW2635-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2635-MONOMER BioCyc EcoCyc:EG12387-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12387-MONOMER BioCyc MetaCyc:EG12387-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12387-MONOMER COG COG0579 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0579 DIP DIP-12096N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12096N DOI 10.1007/BF00245306 http://dx.doi.org/10.1007/BF00245306 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2003.03867.x http://dx.doi.org/10.1046/j.1365-2958.2003.03867.x DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01977-07 http://dx.doi.org/10.1128/JB.01977-07 EC_number EC:1.1.3.15 {ECO:0000255|HAMAP-Rule:MF_00990} http://www.genome.jp/dbget-bin/www_bget?EC:1.1.3.15 {ECO:0000255|HAMAP-Rule:MF_00990} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M88334 http://www.ebi.ac.uk/ena/data/view/M88334 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.1.3.15 {ECO:0000255|HAMAP-Rule:MF_00990} http://enzyme.expasy.org/EC/1.1.3.15 {ECO:0000255|HAMAP-Rule:MF_00990} EchoBASE EB2288 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2288 EcoGene EG12387 http://www.ecogene.org/geneInfo.php?eg_id=EG12387 EnsemblBacteria AAC75707 http://www.ensemblgenomes.org/id/AAC75707 EnsemblBacteria AAC75707 http://www.ensemblgenomes.org/id/AAC75707 EnsemblBacteria BAA16521 http://www.ensemblgenomes.org/id/BAA16521 EnsemblBacteria BAA16521 http://www.ensemblgenomes.org/id/BAA16521 EnsemblBacteria BAA16521 http://www.ensemblgenomes.org/id/BAA16521 EnsemblBacteria b2660 http://www.ensemblgenomes.org/id/b2660 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0034419 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034419 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_function GO:0052852 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052852 GO_function GO:0052853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052853 GO_function GO:0052854 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052854 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 GeneID 948069 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948069 HAMAP MF_00990 http://hamap.expasy.org/unirule/MF_00990 HOGENOM HOG000245180 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000245180&db=HOGENOM6 InParanoid P37339 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37339 IntAct P37339 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37339* IntEnz 1.1.3.15 {ECO:0000255|HAMAP-Rule:MF_00990} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.3.15 {ECO:0000255|HAMAP-Rule:MF_00990} InterPro IPR006076 http://www.ebi.ac.uk/interpro/entry/IPR006076 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 InterPro IPR030862 http://www.ebi.ac.uk/interpro/entry/IPR030862 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2635 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2635 KEGG_Gene eco:b2660 http://www.genome.jp/dbget-bin/www_bget?eco:b2660 KEGG_Orthology KO:K15736 http://www.genome.jp/dbget-bin/www_bget?KO:K15736 MINT MINT-1301841 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1301841 OMA GVHFTRM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GVHFTRM PSORT swissprot:LHGO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LHGO_ECOLI PSORT-B swissprot:LHGO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LHGO_ECOLI PSORT2 swissprot:LHGO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LHGO_ECOLI Pfam PF01266 http://pfam.xfam.org/family/PF01266 Phobius swissprot:LHGO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LHGO_ECOLI PhylomeDB P37339 http://phylomedb.org/?seqid=P37339 ProteinModelPortal P37339 http://www.proteinmodelportal.org/query/uniprot/P37339 PubMed 14731280 http://www.ncbi.nlm.nih.gov/pubmed/14731280 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18390652 http://www.ncbi.nlm.nih.gov/pubmed/18390652 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 8297211 http://www.ncbi.nlm.nih.gov/pubmed/8297211 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417146 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417146 RefSeq WP_000271909 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000271909 STRING 511145.b2660 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2660&targetmode=cogs STRING COG0579 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0579&targetmode=cogs SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 UniProtKB LHGO_ECOLI http://www.uniprot.org/uniprot/LHGO_ECOLI UniProtKB-AC P37339 http://www.uniprot.org/uniprot/P37339 charge swissprot:LHGO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LHGO_ECOLI eggNOG COG0579 http://eggnogapi.embl.de/nog_data/html/tree/COG0579 eggNOG ENOG4105D5U http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D5U epestfind swissprot:LHGO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LHGO_ECOLI garnier swissprot:LHGO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LHGO_ECOLI helixturnhelix swissprot:LHGO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LHGO_ECOLI hmoment swissprot:LHGO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LHGO_ECOLI iep swissprot:LHGO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LHGO_ECOLI inforesidue swissprot:LHGO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LHGO_ECOLI octanol swissprot:LHGO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LHGO_ECOLI pepcoil swissprot:LHGO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LHGO_ECOLI pepdigest swissprot:LHGO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LHGO_ECOLI pepinfo swissprot:LHGO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LHGO_ECOLI pepnet swissprot:LHGO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LHGO_ECOLI pepstats swissprot:LHGO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LHGO_ECOLI pepwheel swissprot:LHGO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LHGO_ECOLI pepwindow swissprot:LHGO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LHGO_ECOLI sigcleave swissprot:LHGO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LHGO_ECOLI ## Database ID URL or Descriptions # BioGrid 4263227 7 # CATALYTIC ACTIVITY YCDT_ECOLI 2 GTP = 2 diphosphate + cyclic di-3',5'- guanylate. # CDD cd01949 GGDEF # COFACTOR YCDT_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250}; Note=Binds 1 Mg(2+) ion per monomer. {ECO 0000250}; # DISRUPTION PHENOTYPE A slight increase in motility. No visible effect on curli production. {ECO:0000269|PubMed 18713317}. # EcoGene EG13866 ycdT # FUNCTION YCDT_ECOLI A probable diguanylate cyclase, overexpression leads to a strong repression of swimming; swimming returns to normal when residues 359-360 are both mutated to Ala. Overexpression also leads to a 20-fold increase in c-di-GMP levels in vivo. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria. {ECO 0000269|PubMed 18713317}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005525 GTP binding; IEA:UniProtKB-KW. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0052621 diguanylate cyclase activity; IMP:EcoCyc. # GO_process GO:0051271 negative regulation of cellular component movement; IMP:EcoCyc. # GO_process GO:0090609 single-species submerged biofilm formation; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # INDUCTION CsrA binds to the mRNA and reduces its levels. Expressed at low levels at both 28 and 37 degrees Celsius. {ECO:0000269|PubMed 19332833}. # InterPro IPR000160 GGDEF_dom # InterPro IPR029787 Nucleotide_cyclase # InterPro IPR033424 MASE4 # Organism YCDT_ECOLI Escherichia coli (strain K12) # PATHWAY YCDT_ECOLI Purine metabolism; 3',5'-cyclic di-GMP biosynthesis. # PATRIC 32117283 VBIEscCol129921_1065 # PIR G64844 G64844 # PROSITE PS50887 GGDEF # Pfam PF00990 GGDEF # Pfam PF17158 MASE4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCDT_ECOLI Probable diguanylate cyclase YcdT # RefSeq NP_415544 NC_000913.3 # RefSeq WP_000409873 NZ_LN832404.1 # SIMILARITY Contains 1 GGDEF domain. {ECO:0000255|PROSITE- ProRule PRU00095}. # SMART SM00267 GGDEF # SUBCELLULAR LOCATION YCDT_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT Homodimer. {ECO 0000250}. # SUPFAM SSF55073 SSF55073 # TIGRFAMs TIGR00254 GGDEF # eggNOG ENOG4105BZU Bacteria # eggNOG ENOG410XNMH LUCA BLAST swissprot:YCDT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCDT_ECOLI BioCyc ECOL316407:JW5143-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5143-MONOMER BioCyc EcoCyc:G6532-MONOMER http://biocyc.org/getid?id=EcoCyc:G6532-MONOMER BioCyc MetaCyc:G6532-MONOMER http://biocyc.org/getid?id=MetaCyc:G6532-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1099/mic.0.024257-0 http://dx.doi.org/10.1099/mic.0.024257-0 DOI 10.1111/j.1365-2958.2008.06411.x http://dx.doi.org/10.1111/j.1365-2958.2008.06411.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.7.65 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.65 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.7.65 http://enzyme.expasy.org/EC/2.7.7.65 EchoBASE EB3626 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3626 EcoGene EG13866 http://www.ecogene.org/geneInfo.php?eg_id=EG13866 EnsemblBacteria AAC74110 http://www.ensemblgenomes.org/id/AAC74110 EnsemblBacteria AAC74110 http://www.ensemblgenomes.org/id/AAC74110 EnsemblBacteria BAA35810 http://www.ensemblgenomes.org/id/BAA35810 EnsemblBacteria BAA35810 http://www.ensemblgenomes.org/id/BAA35810 EnsemblBacteria BAA35810 http://www.ensemblgenomes.org/id/BAA35810 EnsemblBacteria b1025 http://www.ensemblgenomes.org/id/b1025 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0052621 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052621 GO_process GO:0051271 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051271 GO_process GO:0090609 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090609 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 945593 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945593 HOGENOM HOG000118907 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118907&db=HOGENOM6 InParanoid P75908 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75908 IntEnz 2.7.7.65 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.65 InterPro IPR000160 http://www.ebi.ac.uk/interpro/entry/IPR000160 InterPro IPR029787 http://www.ebi.ac.uk/interpro/entry/IPR029787 InterPro IPR033424 http://www.ebi.ac.uk/interpro/entry/IPR033424 KEGG_Gene ecj:JW5143 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5143 KEGG_Gene eco:b1025 http://www.genome.jp/dbget-bin/www_bget?eco:b1025 OMA WNGVSVI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WNGVSVI PROSITE PS50887 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50887 PSORT swissprot:YCDT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCDT_ECOLI PSORT-B swissprot:YCDT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCDT_ECOLI PSORT2 swissprot:YCDT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCDT_ECOLI Pfam PF00990 http://pfam.xfam.org/family/PF00990 Pfam PF17158 http://pfam.xfam.org/family/PF17158 Phobius swissprot:YCDT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCDT_ECOLI PhylomeDB P75908 http://phylomedb.org/?seqid=P75908 ProteinModelPortal P75908 http://www.proteinmodelportal.org/query/uniprot/P75908 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18713317 http://www.ncbi.nlm.nih.gov/pubmed/18713317 PubMed 19332833 http://www.ncbi.nlm.nih.gov/pubmed/19332833 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415544 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415544 RefSeq WP_000409873 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000409873 SMART SM00267 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00267 SMR P75908 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75908 STRING 511145.b1025 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1025&targetmode=cogs SUPFAM SSF55073 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55073 TIGRFAMs TIGR00254 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00254 UniProtKB YCDT_ECOLI http://www.uniprot.org/uniprot/YCDT_ECOLI UniProtKB-AC P75908 http://www.uniprot.org/uniprot/P75908 charge swissprot:YCDT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCDT_ECOLI eggNOG ENOG4105BZU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZU eggNOG ENOG410XNMH http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNMH epestfind swissprot:YCDT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCDT_ECOLI garnier swissprot:YCDT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCDT_ECOLI helixturnhelix swissprot:YCDT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCDT_ECOLI hmoment swissprot:YCDT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCDT_ECOLI iep swissprot:YCDT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCDT_ECOLI inforesidue swissprot:YCDT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCDT_ECOLI octanol swissprot:YCDT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCDT_ECOLI pepcoil swissprot:YCDT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCDT_ECOLI pepdigest swissprot:YCDT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCDT_ECOLI pepinfo swissprot:YCDT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCDT_ECOLI pepnet swissprot:YCDT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCDT_ECOLI pepstats swissprot:YCDT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCDT_ECOLI pepwheel swissprot:YCDT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCDT_ECOLI pepwindow swissprot:YCDT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCDT_ECOLI sigcleave swissprot:YCDT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCDT_ECOLI ## Database ID URL or Descriptions # EcoGene EG10237 dnaC # FUNCTION DNAC_ECOLI This protein is required for chromosomal replication. It forms, in concert with DnaB protein and other prepriming proteins DnaT, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'. # GO_component GO:1990077 primosome complex; IEA:UniProtKB-KW. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0043565 sequence-specific DNA binding; IBA:GO_Central. # GO_process GO:0006269 DNA replication, synthesis of RNA primer; IEA:UniProtKB-KW. # GO_process GO:0006271 DNA strand elongation involved in DNA replication; IGI:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.300 -; 1. # INDUCTION Induced by hydroxyurea. {ECO:0000269|PubMed 20005847}. # INTERACTION DNAC_ECOLI P0ACB0 dnaB; NbExp=9; IntAct=EBI-549012, EBI-548978; # IntAct P0AEF0 13 # InterPro IPR002611 IstB_ATP-bd # InterPro IPR003593 AAA+_ATPase # InterPro IPR027417 P-loop_NTPase # InterPro IPR028350 DNAC/ATP-binding # KEGG_Brite ko03032 DNA replication proteins # Organism DNAC_ECOLI Escherichia coli (strain K12) # PATRIC 32124330 VBIEscCol129921_4508 # PIR A28484 XMECNC # PIRSF PIRSF003073 DNAC_TnpB_IstB # Pfam PF01695 IstB_IS21 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DNAC_ECOLI DNA replication protein DnaC # RefSeq NP_418781 NC_000913.3 # RefSeq WP_000799911 NZ_LN832404.1 # SIMILARITY Belongs to the DnaC family. {ECO 0000305}. # SMART SM00382 AAA # SUPFAM SSF52540 SSF52540 # eggNOG COG1484 LUCA # eggNOG ENOG4106CVF Bacteria BLAST swissprot:DNAC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DNAC_ECOLI BioCyc ECOL316407:JW4325-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4325-MONOMER BioCyc EcoCyc:EG10237-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10237-MONOMER COG COG1484 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1484 DIP DIP-9457N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9457N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.83.5.1256 http://dx.doi.org/10.1073/pnas.83.5.1256 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J04030 http://www.ebi.ac.uk/ena/data/view/J04030 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB0233 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0233 EcoGene EG10237 http://www.ecogene.org/geneInfo.php?eg_id=EG10237 EnsemblBacteria AAC77317 http://www.ensemblgenomes.org/id/AAC77317 EnsemblBacteria AAC77317 http://www.ensemblgenomes.org/id/AAC77317 EnsemblBacteria BAE78351 http://www.ensemblgenomes.org/id/BAE78351 EnsemblBacteria BAE78351 http://www.ensemblgenomes.org/id/BAE78351 EnsemblBacteria BAE78351 http://www.ensemblgenomes.org/id/BAE78351 EnsemblBacteria b4361 http://www.ensemblgenomes.org/id/b4361 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:1990077 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990077 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006269 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006269 GO_process GO:0006271 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006271 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948864 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948864 HOGENOM HOG000120230 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120230&db=HOGENOM6 InParanoid P0AEF0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEF0 IntAct P0AEF0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEF0* InterPro IPR002611 http://www.ebi.ac.uk/interpro/entry/IPR002611 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR028350 http://www.ebi.ac.uk/interpro/entry/IPR028350 KEGG_Brite ko03032 http://www.genome.jp/dbget-bin/www_bget?ko03032 KEGG_Gene ecj:JW4325 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4325 KEGG_Gene eco:b4361 http://www.genome.jp/dbget-bin/www_bget?eco:b4361 KEGG_Orthology KO:K02315 http://www.genome.jp/dbget-bin/www_bget?KO:K02315 MINT MINT-1276712 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1276712 OMA VGDLMKR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VGDLMKR PSORT swissprot:DNAC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DNAC_ECOLI PSORT-B swissprot:DNAC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DNAC_ECOLI PSORT2 swissprot:DNAC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DNAC_ECOLI Pfam PF01695 http://pfam.xfam.org/family/PF01695 Phobius swissprot:DNAC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DNAC_ECOLI PhylomeDB P0AEF0 http://phylomedb.org/?seqid=P0AEF0 ProteinModelPortal P0AEF0 http://www.proteinmodelportal.org/query/uniprot/P0AEF0 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 2844800 http://www.ncbi.nlm.nih.gov/pubmed/2844800 PubMed 3006041 http://www.ncbi.nlm.nih.gov/pubmed/3006041 PubMed 3301836 http://www.ncbi.nlm.nih.gov/pubmed/3301836 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_418781 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418781 RefSeq WP_000799911 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000799911 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 STRING 511145.b4361 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4361&targetmode=cogs STRING COG1484 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1484&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB DNAC_ECOLI http://www.uniprot.org/uniprot/DNAC_ECOLI UniProtKB-AC P0AEF0 http://www.uniprot.org/uniprot/P0AEF0 charge swissprot:DNAC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DNAC_ECOLI eggNOG COG1484 http://eggnogapi.embl.de/nog_data/html/tree/COG1484 eggNOG ENOG4106CVF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106CVF epestfind swissprot:DNAC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DNAC_ECOLI garnier swissprot:DNAC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DNAC_ECOLI helixturnhelix swissprot:DNAC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DNAC_ECOLI hmoment swissprot:DNAC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DNAC_ECOLI iep swissprot:DNAC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DNAC_ECOLI inforesidue swissprot:DNAC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DNAC_ECOLI octanol swissprot:DNAC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DNAC_ECOLI pepcoil swissprot:DNAC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DNAC_ECOLI pepdigest swissprot:DNAC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DNAC_ECOLI pepinfo swissprot:DNAC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DNAC_ECOLI pepnet swissprot:DNAC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DNAC_ECOLI pepstats swissprot:DNAC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DNAC_ECOLI pepwheel swissprot:DNAC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DNAC_ECOLI pepwindow swissprot:DNAC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DNAC_ECOLI sigcleave swissprot:DNAC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DNAC_ECOLI ## Database ID URL or Descriptions # AltName RL10_ECOLI 50S ribosomal protein L8 # EcoGene EG10871 rplJ # FUNCTION RL10_ECOLI Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. {ECO 0000269|PubMed 15923259}. # FUNCTION RL10_ECOLI Protein L10 is also a translational repressor protein. It controls the translation of the rplJL-rpoBC operon by binding to its mRNA. {ECO 0000269|PubMed 2448482}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0022625 cytosolic large ribosomal subunit; IDA:EcoCyc. # GO_function GO:0003735 structural constituent of ribosome; IBA:GO_Central. # GO_function GO:0070180 large ribosomal subunit rRNA binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006412 translation; IBA:GO_Central. # GO_process GO:0006417 regulation of translation; IEA:UniProtKB-KW. # GO_process GO:0042254 ribosome biogenesis; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_function GO:0019843 rRNA binding # GOslim_process GO:0006412 translation # GOslim_process GO:0008150 biological_process # GOslim_process GO:0042254 ribosome biogenesis # HAMAP MF_00362 Ribosomal_L10 # IntAct P0A7J3 52 # InterPro IPR001790 Ribosomal_L10P # InterPro IPR002363 Ribosomal_L10_eubac_CS # InterPro IPR022973 Ribosomal_L10 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 M00179 Ribosome, archaea # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=17580; Mass_error=2; Method=Electrospray; Range=2-165; Evidence={ECO:0000269|PubMed 15923259}; # MASS SPECTROMETRY Mass=17581.1; Method=MALDI; Range=2-165; Evidence={ECO:0000269|PubMed 10094780}; # MASS SPECTROMETRY Mass=66643; Mass_error=13; Method=Electrospray; Range=2-165; Note=Isolated L10(L12)4.; Evidence={ECO:0000269|PubMed 15923259}; # MISCELLANEOUS Ribosomal protein L8 appears to be an aggregate of ribosomal proteins L7/L12 and L10. {ECO:0000269|PubMed 773698}. # Organism RL10_ECOLI Escherichia coli (strain K12) # PATRIC 32123491 VBIEscCol129921_4098 # PDB 3J7Z EM; 3.90 A; 5=1-165 # PDB 3J9Y EM; 3.90 A; 5=1-165 # PDB 3J9Z EM; 3.60 A; LD=2-165 # PDB 3JA1 EM; 3.60 A; LJ=2-165 # PDB 3JCJ EM; 3.70 A; e=1-165 # PDB 4UY8 EM; 3.80 A; 5=1-148 # PDB 4V6N EM; 12.10 A; AJ=2-165 # PDB 4V6O EM; 14.70 A; BJ=2-165 # PDB 4V6P EM; 13.50 A; BJ=2-165 # PDB 4V6Q EM; 11.50 A; BJ=2-165 # PDB 4V6R EM; 11.50 A; BJ=2-165 # PDB 4V6S EM; 13.10 A; AJ=2-165 # PDB 4V6V EM; 9.80 A; BJ=2-165 # PDB 4V7B EM; 6.80 A; B5=1-165 # PDB 4V7C EM; 7.60 A; BJ=1-165 # PDB 4V7D EM; 7.60 A; AJ=1-165 # PDB 4V85 X-ray; 3.20 A; H=1-165 # PDB 4V89 X-ray; 3.70 A; BH=1-165 # PDB 4V9O X-ray; 2.90 A; A5/C5/E5=1-165 # PDB 4V9P X-ray; 2.90 A; A5/E5=1-165 # PDB 4YBB X-ray; 2.10 A; DI=2-136 # PDB 5ADY EM; 4.50 A; 7=1-165 # PDB 5AFI EM; 2.90 A; 5=1-165 # PDB 5GAD EM; 3.70 A; I=1-165 # PDB 5GAE EM; 3.33 A; I=1-165 # PDB 5GAF EM; 4.30 A; I=2-126 # PDB 5GAG EM; 3.80 A; I=1-165 # PDB 5GAH EM; 3.80 A; I=1-165 # PDB 5IQR EM; 3.00 A; H=1-165 # PDB 5IT8 X-ray; 3.12 A; DI=2-136 # PDB 5J5B X-ray; 2.80 A; DI=2-136 # PDB 5J7L X-ray; 3.00 A; DI=2-136 # PDB 5J88 X-ray; 3.32 A; DI=2-136 # PDB 5J8A X-ray; 3.10 A; DI=2-136 # PDB 5J91 X-ray; 2.96 A; DI=2-136 # PDB 5JC9 X-ray; 3.03 A; DI=2-136 # PDB 5KCR EM; 3.60 A; 1J=1-165 # PDB 5KCS EM; 3.90 A; 1J=1-165 # PDB 5KPS EM; 3.90 A; H=1-165 # PDB 5KPV EM; 4.10 A; G=1-165 # PDB 5KPW EM; 3.90 A; G=1-165 # PDB 5KPX EM; 3.90 A; G=1-165 # PDB 5L3P EM; 3.70 A; J=1-165 # PIR S12574 R5EC10 # PROSITE PS01109 RIBOSOMAL_L10 # Pfam PF00466 Ribosomal_L10 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RL10_ECOLI 50S ribosomal protein L10 # RefSeq NP_418412 NC_000913.3 # RefSeq WP_001207201 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein L10P family. {ECO 0000305}. # SUBUNIT Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which 2 L12 dimers bind in a sequential fashion forming a pentameric L10(L12)(L12)2 complex. Two L12 dimers associate with a copy of L10 to form a very strong complex (called L8). {ECO:0000269|PubMed 15923259}. # eggNOG COG0244 LUCA # eggNOG ENOG4108VZM Bacteria BLAST swissprot:RL10_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RL10_ECOLI BioCyc ECOL316407:JW3948-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3948-MONOMER BioCyc EcoCyc:EG10871-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10871-MONOMER BioCyc MetaCyc:EG10871-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10871-MONOMER COG COG0244 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0244 DIP DIP-35816N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35816N DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1016/0014-5793(76)80267-0 http://dx.doi.org/10.1016/0014-5793(76)80267-0 DOI 10.1016/0014-5793(76)80870-8 http://dx.doi.org/10.1016/0014-5793(76)80870-8 DOI 10.1016/0022-2836(87)90287-7 http://dx.doi.org/10.1016/0022-2836(87)90287-7 DOI 10.1016/j.celrep.2014.09.011 http://dx.doi.org/10.1016/j.celrep.2014.09.011 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0502193102 http://dx.doi.org/10.1073/pnas.0502193102 DOI 10.1073/pnas.76.4.1697 http://dx.doi.org/10.1073/pnas.76.4.1697 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1093/nar/gkr1031 http://dx.doi.org/10.1093/nar/gkr1031 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00339 http://www.ebi.ac.uk/ena/data/view/V00339 EchoBASE EB0864 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0864 EcoGene EG10871 http://www.ecogene.org/geneInfo.php?eg_id=EG10871 EnsemblBacteria AAC76959 http://www.ensemblgenomes.org/id/AAC76959 EnsemblBacteria AAC76959 http://www.ensemblgenomes.org/id/AAC76959 EnsemblBacteria BAE77335 http://www.ensemblgenomes.org/id/BAE77335 EnsemblBacteria BAE77335 http://www.ensemblgenomes.org/id/BAE77335 EnsemblBacteria BAE77335 http://www.ensemblgenomes.org/id/BAE77335 EnsemblBacteria b3985 http://www.ensemblgenomes.org/id/b3985 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0022625 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022625 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_function GO:0070180 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070180 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GO_process GO:0006417 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006417 GO_process GO:0042254 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042254 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0042254 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042254 GeneID 948490 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948490 HAMAP MF_00362 http://hamap.expasy.org/unirule/MF_00362 HOGENOM HOG000004851 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000004851&db=HOGENOM6 InParanoid P0A7J3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7J3 IntAct P0A7J3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7J3* InterPro IPR001790 http://www.ebi.ac.uk/interpro/entry/IPR001790 InterPro IPR002363 http://www.ebi.ac.uk/interpro/entry/IPR002363 InterPro IPR022973 http://www.ebi.ac.uk/interpro/entry/IPR022973 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW3948 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3948 KEGG_Gene eco:b3985 http://www.genome.jp/dbget-bin/www_bget?eco:b3985 KEGG_Orthology KO:K02864 http://www.genome.jp/dbget-bin/www_bget?KO:K02864 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 MINT MINT-1264502 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1264502 OMA AKANPAF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AKANPAF PDB 3J7Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J7Z PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 4UY8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4UY8 PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5ADY http://www.ebi.ac.uk/pdbe-srv/view/entry/5ADY PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5GAD http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAD PDB 5GAE http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAE PDB 5GAF http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAF PDB 5GAG http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAG PDB 5GAH http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAH PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 3J7Z http://www.ebi.ac.uk/pdbsum/3J7Z PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 4UY8 http://www.ebi.ac.uk/pdbsum/4UY8 PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5ADY http://www.ebi.ac.uk/pdbsum/5ADY PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5GAD http://www.ebi.ac.uk/pdbsum/5GAD PDBsum 5GAE http://www.ebi.ac.uk/pdbsum/5GAE PDBsum 5GAF http://www.ebi.ac.uk/pdbsum/5GAF PDBsum 5GAG http://www.ebi.ac.uk/pdbsum/5GAG PDBsum 5GAH http://www.ebi.ac.uk/pdbsum/5GAH PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PROSITE PS01109 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01109 PSORT swissprot:RL10_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RL10_ECOLI PSORT-B swissprot:RL10_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RL10_ECOLI PSORT2 swissprot:RL10_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RL10_ECOLI Pfam PF00466 http://pfam.xfam.org/family/PF00466 Phobius swissprot:RL10_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RL10_ECOLI PhylomeDB P0A7J3 http://phylomedb.org/?seqid=P0A7J3 ProteinModelPortal P0A7J3 http://www.proteinmodelportal.org/query/uniprot/P0A7J3 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 15923259 http://www.ncbi.nlm.nih.gov/pubmed/15923259 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 22102582 http://www.ncbi.nlm.nih.gov/pubmed/22102582 PubMed 2448482 http://www.ncbi.nlm.nih.gov/pubmed/2448482 PubMed 25310980 http://www.ncbi.nlm.nih.gov/pubmed/25310980 PubMed 377281 http://www.ncbi.nlm.nih.gov/pubmed/377281 PubMed 773698 http://www.ncbi.nlm.nih.gov/pubmed/773698 PubMed 782920 http://www.ncbi.nlm.nih.gov/pubmed/782920 PubMed 797648 http://www.ncbi.nlm.nih.gov/pubmed/797648 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418412 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418412 RefSeq WP_001207201 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001207201 SMR P0A7J3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7J3 STRING 511145.b3985 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3985&targetmode=cogs STRING COG0244 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0244&targetmode=cogs UniProtKB RL10_ECOLI http://www.uniprot.org/uniprot/RL10_ECOLI UniProtKB-AC P0A7J3 http://www.uniprot.org/uniprot/P0A7J3 charge swissprot:RL10_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RL10_ECOLI eggNOG COG0244 http://eggnogapi.embl.de/nog_data/html/tree/COG0244 eggNOG ENOG4108VZM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108VZM epestfind swissprot:RL10_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RL10_ECOLI garnier swissprot:RL10_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RL10_ECOLI helixturnhelix swissprot:RL10_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RL10_ECOLI hmoment swissprot:RL10_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RL10_ECOLI iep swissprot:RL10_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RL10_ECOLI inforesidue swissprot:RL10_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RL10_ECOLI octanol swissprot:RL10_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RL10_ECOLI pepcoil swissprot:RL10_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RL10_ECOLI pepdigest swissprot:RL10_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RL10_ECOLI pepinfo swissprot:RL10_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RL10_ECOLI pepnet swissprot:RL10_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RL10_ECOLI pepstats swissprot:RL10_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RL10_ECOLI pepwheel swissprot:RL10_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RL10_ECOLI pepwindow swissprot:RL10_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RL10_ECOLI sigcleave swissprot:RL10_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RL10_ECOLI ## Database ID URL or Descriptions # AltName CRA_ECOLI Fructose repressor # BioGrid 4259359 7 # CDD cd01392 HTH_LacI # ENZYME REGULATION Is displaced from DNA by low concentrations of fructose-1-phosphate. {ECO:0000269|PubMed 8230205}. # EcoGene EG10338 cra # FUNCTION CRA_ECOLI Global transcriptional regulator, which plays an important role in the regulation of carbon metabolism. Activates transcription of genes encoding biosynthetic and oxidative enzymes (involved in Krebs cycle, glyoxylate shunt and gluconeogenesis, such as ppsA and fbp). Represses genes involved in sugar catabolism, such as fruB, pfkA, pykF and adhE. Binds asymmetrically to the two half-sites of its operator. {ECO 0000269|PubMed 16115199, ECO 0000269|PubMed 8195118, ECO 0000269|PubMed 8230205, ECO 0000269|PubMed 8550429, ECO 0000269|PubMed 8577250, ECO 0000269|PubMed 8858581, ECO 0000269|PubMed 9084760, ECO 0000269|PubMed 9371462}. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_process GO:0006096 glycolytic process; EXP:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0009750 response to fructose; IEA:InterPro. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 1.10.260.40 -; 1. # IntAct P0ACP1 11 # InterPro IPR000843 HTH_LacI # InterPro IPR001761 Peripla_BP/Lac1_sug-bd_dom # InterPro IPR010982 Lambda_DNA-bd_dom # InterPro IPR012781 Fruct_sucro_rep # InterPro IPR028082 Peripla_BP_I # KEGG_Brite ko03000 Transcription factors # MISCELLANEOUS Activation of transcription is observed when the Cra operator is upstream of the RNA polymerase binding site. Inhibition of transcription is observed when the operator overlaps or is downstream of the RNA polymerase binding site (PubMed:8655535). {ECO 0000305|PubMed:8655535}. # Organism CRA_ECOLI Escherichia coli (strain K12) # PATRIC 32115263 VBIEscCol129921_0083 # PDB 1UXC NMR; -; A=1-57 # PDB 1UXD NMR; -; A=1-57 # PDB 2IKS X-ray; 1.85 A; A/B=44-334 # PIR JU0298 JU0298 # PROSITE PS00356 HTH_LACI_1 # PROSITE PS50932 HTH_LACI_2 # Pfam PF00356 LacI # Pfam PF00532 Peripla_BP_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CRA_ECOLI Catabolite repressor/activator # RefSeq NP_414622 NC_000913.3 # RefSeq WP_000762401 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lacI-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00111}. # SMART SM00354 HTH_LACI # SUBUNIT Homotetramer. {ECO:0000269|PubMed 8195118}. # SUPFAM SSF47413 SSF47413 # SUPFAM SSF53822 SSF53822 # TIGRFAMs TIGR02417 fruct_sucro_rep # eggNOG COG1609 LUCA # eggNOG ENOG4107B7Y Bacteria BLAST swissprot:CRA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CRA_ECOLI BioCyc ECOL316407:JW0078-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0078-MONOMER BioCyc EcoCyc:PD00521 http://biocyc.org/getid?id=EcoCyc:PD00521 COG COG1609 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1609 DIP DIP-35838N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35838N DOI 10.1006/jmbi.1993.1561 http://dx.doi.org/10.1006/jmbi.1993.1561 DOI 10.1006/jmbi.1997.1123 http://dx.doi.org/10.1006/jmbi.1997.1123 DOI 10.1007/BF00273623 http://dx.doi.org/10.1007/BF00273623 DOI 10.1016/0923-2508(96)84003-4 http://dx.doi.org/10.1016/0923-2508(96)84003-4 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1996.6341350.x http://dx.doi.org/10.1046/j.1365-2958.1996.6341350.x DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1111/j.1365-2443.2005.00888.x http://dx.doi.org/10.1111/j.1365-2443.2005.00888.x DOI 10.1111/j.1365-2958.1995.tb02339.x http://dx.doi.org/10.1111/j.1365-2958.1995.tb02339.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M35034 http://www.ebi.ac.uk/ena/data/view/M35034 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X55034 http://www.ebi.ac.uk/ena/data/view/X55034 EMBL X55457 http://www.ebi.ac.uk/ena/data/view/X55457 EchoBASE EB0334 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0334 EcoGene EG10338 http://www.ecogene.org/geneInfo.php?eg_id=EG10338 EnsemblBacteria AAC73191 http://www.ensemblgenomes.org/id/AAC73191 EnsemblBacteria AAC73191 http://www.ensemblgenomes.org/id/AAC73191 EnsemblBacteria BAB96648 http://www.ensemblgenomes.org/id/BAB96648 EnsemblBacteria BAB96648 http://www.ensemblgenomes.org/id/BAB96648 EnsemblBacteria BAB96648 http://www.ensemblgenomes.org/id/BAB96648 EnsemblBacteria b0080 http://www.ensemblgenomes.org/id/b0080 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006096 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006096 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0009750 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009750 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 1.10.260.40 http://www.cathdb.info/version/latest/superfamily/1.10.260.40 GeneID 944804 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944804 HOGENOM HOG000278142 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278142&db=HOGENOM6 InParanoid P0ACP1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACP1 IntAct P0ACP1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACP1* InterPro IPR000843 http://www.ebi.ac.uk/interpro/entry/IPR000843 InterPro IPR001761 http://www.ebi.ac.uk/interpro/entry/IPR001761 InterPro IPR010982 http://www.ebi.ac.uk/interpro/entry/IPR010982 InterPro IPR012781 http://www.ebi.ac.uk/interpro/entry/IPR012781 InterPro IPR028082 http://www.ebi.ac.uk/interpro/entry/IPR028082 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW0078 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0078 KEGG_Gene eco:b0080 http://www.genome.jp/dbget-bin/www_bget?eco:b0080 KEGG_Orthology KO:K03435 http://www.genome.jp/dbget-bin/www_bget?KO:K03435 MINT MINT-1252433 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1252433 OMA WANDSFP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WANDSFP PDB 1UXC http://www.ebi.ac.uk/pdbe-srv/view/entry/1UXC PDB 1UXD http://www.ebi.ac.uk/pdbe-srv/view/entry/1UXD PDB 2IKS http://www.ebi.ac.uk/pdbe-srv/view/entry/2IKS PDBsum 1UXC http://www.ebi.ac.uk/pdbsum/1UXC PDBsum 1UXD http://www.ebi.ac.uk/pdbsum/1UXD PDBsum 2IKS http://www.ebi.ac.uk/pdbsum/2IKS PROSITE PS00356 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00356 PROSITE PS50932 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50932 PSORT swissprot:CRA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CRA_ECOLI PSORT-B swissprot:CRA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CRA_ECOLI PSORT2 swissprot:CRA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CRA_ECOLI Pfam PF00356 http://pfam.xfam.org/family/PF00356 Pfam PF00532 http://pfam.xfam.org/family/PF00532 Phobius swissprot:CRA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CRA_ECOLI PhylomeDB P0ACP1 http://phylomedb.org/?seqid=P0ACP1 ProteinModelPortal P0ACP1 http://www.proteinmodelportal.org/query/uniprot/P0ACP1 PubMed 16115199 http://www.ncbi.nlm.nih.gov/pubmed/16115199 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1851954 http://www.ncbi.nlm.nih.gov/pubmed/1851954 PubMed 2198273 http://www.ncbi.nlm.nih.gov/pubmed/2198273 PubMed 8195118 http://www.ncbi.nlm.nih.gov/pubmed/8195118 PubMed 8230205 http://www.ncbi.nlm.nih.gov/pubmed/8230205 PubMed 8550429 http://www.ncbi.nlm.nih.gov/pubmed/8550429 PubMed 8577250 http://www.ncbi.nlm.nih.gov/pubmed/8577250 PubMed 8655535 http://www.ncbi.nlm.nih.gov/pubmed/8655535 PubMed 8858581 http://www.ncbi.nlm.nih.gov/pubmed/8858581 PubMed 9084760 http://www.ncbi.nlm.nih.gov/pubmed/9084760 PubMed 9237914 http://www.ncbi.nlm.nih.gov/pubmed/9237914 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9371462 http://www.ncbi.nlm.nih.gov/pubmed/9371462 RefSeq NP_414622 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414622 RefSeq WP_000762401 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000762401 SMART SM00354 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00354 SMR P0ACP1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACP1 STRING 511145.b0080 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0080&targetmode=cogs STRING COG1609 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1609&targetmode=cogs SUPFAM SSF47413 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47413 SUPFAM SSF53822 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822 TIGRFAMs TIGR02417 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02417 UniProtKB CRA_ECOLI http://www.uniprot.org/uniprot/CRA_ECOLI UniProtKB-AC P0ACP1 http://www.uniprot.org/uniprot/P0ACP1 charge swissprot:CRA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CRA_ECOLI eggNOG COG1609 http://eggnogapi.embl.de/nog_data/html/tree/COG1609 eggNOG ENOG4107B7Y http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107B7Y epestfind swissprot:CRA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CRA_ECOLI garnier swissprot:CRA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CRA_ECOLI helixturnhelix swissprot:CRA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CRA_ECOLI hmoment swissprot:CRA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CRA_ECOLI iep swissprot:CRA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CRA_ECOLI inforesidue swissprot:CRA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CRA_ECOLI octanol swissprot:CRA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CRA_ECOLI pepcoil swissprot:CRA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CRA_ECOLI pepdigest swissprot:CRA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CRA_ECOLI pepinfo swissprot:CRA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CRA_ECOLI pepnet swissprot:CRA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CRA_ECOLI pepstats swissprot:CRA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CRA_ECOLI pepwheel swissprot:CRA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CRA_ECOLI pepwindow swissprot:CRA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CRA_ECOLI sigcleave swissprot:CRA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CRA_ECOLI ## Database ID URL or Descriptions # FUNCTION TRAB1_ECOLI Involved in F pilus assembly. # GO_function GO:0016887 ATPase activity; IDA:CACAO. # GO_process GO:0000746 conjugation; IEA:UniProtKB-KW. # GOslim_function GO:0016887 ATPase activity # GOslim_process GO:0008150 biological_process # InterPro IPR005498 T4SS_VirB10/TraB/TrbI # Organism TRAB1_ECOLI Escherichia coli (strain K12) # Pfam PF03743 TrbI # RecName TRAB1_ECOLI Protein TraB # RefSeq NP_061457 NC_002483.1 # RefSeq WP_000146685 NZ_CP014273.1 # RefSeq YP_001711962 NC_010409.1 # RefSeq YP_001965444 NC_010862.1 # RefSeq YP_003937621 NC_014615.1 # RefSeq YP_006953831 NC_019089.1 # RefSeq YP_008997954 NC_023315.1 # RefSeq YP_009066482 NC_025106.1 # RefSeq YP_009071234 NC_025179.1 # RefSeq YP_190140 NC_006671.1 # RefSeq YP_443980 NC_007675.1 # SIMILARITY Belongs to the TraB family. {ECO 0000305}. BLAST swissprot:TRAB1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRAB1_ECOLI DIP DIP-16929N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-16929N EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL U01159 http://www.ebi.ac.uk/ena/data/view/U01159 EMBL U51860 http://www.ebi.ac.uk/ena/data/view/U51860 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_process GO:0000746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000746 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 1263578 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263578 GeneID 13906776 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13906776 GeneID 18194780 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18194780 GeneID 20471972 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20471972 GeneID 20493306 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20493306 GeneID 3244814 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3244814 GeneID 3853419 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3853419 GeneID 5962183 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5962183 GeneID 6382240 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6382240 GeneID 9846153 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9846153 InterPro IPR005498 http://www.ebi.ac.uk/interpro/entry/IPR005498 OMA FMSGDKN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FMSGDKN PSORT swissprot:TRAB1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRAB1_ECOLI PSORT-B swissprot:TRAB1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRAB1_ECOLI PSORT2 swissprot:TRAB1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRAB1_ECOLI Pfam PF03743 http://pfam.xfam.org/family/PF03743 Phobius swissprot:TRAB1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRAB1_ECOLI ProteinModelPortal P41067 http://www.proteinmodelportal.org/query/uniprot/P41067 PubMed 7915817 http://www.ncbi.nlm.nih.gov/pubmed/7915817 PubMed 8655498 http://www.ncbi.nlm.nih.gov/pubmed/8655498 RefSeq NP_061457 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061457 RefSeq WP_000146685 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000146685 RefSeq YP_001711962 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001711962 RefSeq YP_001965444 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001965444 RefSeq YP_003937621 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_003937621 RefSeq YP_006953831 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_006953831 RefSeq YP_008997954 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_008997954 RefSeq YP_009066482 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009066482 RefSeq YP_009071234 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009071234 RefSeq YP_190140 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_190140 RefSeq YP_443980 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_443980 UniProtKB TRAB1_ECOLI http://www.uniprot.org/uniprot/TRAB1_ECOLI UniProtKB-AC P41067 http://www.uniprot.org/uniprot/P41067 charge swissprot:TRAB1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRAB1_ECOLI epestfind swissprot:TRAB1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRAB1_ECOLI garnier swissprot:TRAB1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRAB1_ECOLI helixturnhelix swissprot:TRAB1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRAB1_ECOLI hmoment swissprot:TRAB1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRAB1_ECOLI iep swissprot:TRAB1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRAB1_ECOLI inforesidue swissprot:TRAB1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRAB1_ECOLI octanol swissprot:TRAB1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRAB1_ECOLI pepcoil swissprot:TRAB1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRAB1_ECOLI pepdigest swissprot:TRAB1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRAB1_ECOLI pepinfo swissprot:TRAB1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRAB1_ECOLI pepnet swissprot:TRAB1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRAB1_ECOLI pepstats swissprot:TRAB1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRAB1_ECOLI pepwheel swissprot:TRAB1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRAB1_ECOLI pepwindow swissprot:TRAB1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRAB1_ECOLI sigcleave swissprot:TRAB1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRAB1_ECOLI ## Database ID URL or Descriptions # BioGrid 4259578 4 # EcoGene EG12868 yciN # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # IntAct P0AB61 9 # InterPro IPR019633 DUF2498 # Organism YCIN_ECOLI Escherichia coli (strain K12) # PATRIC 32117804 VBIEscCol129921_1322 # PIR D64875 D64875 # Pfam PF10692 DUF2498 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCIN_ECOLI Protein YciN # RefSeq NP_415789 NC_000913.3 # RefSeq WP_001031530 NZ_LN832404.1 # eggNOG ENOG4105RKX Bacteria # eggNOG ENOG4111PJF LUCA BLAST swissprot:YCIN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCIN_ECOLI BioCyc ECOL316407:JW1265-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1265-MONOMER BioCyc EcoCyc:EG12868-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12868-MONOMER DIP DIP-35851N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35851N DOI 10.1016/0022-2836(86)90129-4 http://dx.doi.org/10.1016/0022-2836(86)90129-4 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1111/j.1574-6968.1998.tb13343.x http://dx.doi.org/10.1111/j.1574-6968.1998.tb13343.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X04475 http://www.ebi.ac.uk/ena/data/view/X04475 EchoBASE EB2709 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2709 EcoGene EG12868 http://www.ecogene.org/geneInfo.php?eg_id=EG12868 EnsemblBacteria AAC74355 http://www.ensemblgenomes.org/id/AAC74355 EnsemblBacteria AAC74355 http://www.ensemblgenomes.org/id/AAC74355 EnsemblBacteria BAA14810 http://www.ensemblgenomes.org/id/BAA14810 EnsemblBacteria BAA14810 http://www.ensemblgenomes.org/id/BAA14810 EnsemblBacteria BAA14810 http://www.ensemblgenomes.org/id/BAA14810 EnsemblBacteria b1273 http://www.ensemblgenomes.org/id/b1273 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GeneID 945860 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945860 HOGENOM HOG000274156 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000274156&db=HOGENOM6 InParanoid P0AB61 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AB61 IntAct P0AB61 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AB61* InterPro IPR019633 http://www.ebi.ac.uk/interpro/entry/IPR019633 KEGG_Gene ecj:JW1265 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1265 KEGG_Gene eco:b1273 http://www.genome.jp/dbget-bin/www_bget?eco:b1273 OMA NTTAVFN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NTTAVFN PSORT swissprot:YCIN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCIN_ECOLI PSORT-B swissprot:YCIN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCIN_ECOLI PSORT2 swissprot:YCIN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCIN_ECOLI Pfam PF10692 http://pfam.xfam.org/family/PF10692 Phobius swissprot:YCIN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCIN_ECOLI ProteinModelPortal P0AB61 http://www.proteinmodelportal.org/query/uniprot/P0AB61 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3029379 http://www.ncbi.nlm.nih.gov/pubmed/3029379 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9868784 http://www.ncbi.nlm.nih.gov/pubmed/9868784 RefSeq NP_415789 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415789 RefSeq WP_001031530 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001031530 SMR P0AB61 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AB61 STRING 511145.b1273 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1273&targetmode=cogs UniProtKB YCIN_ECOLI http://www.uniprot.org/uniprot/YCIN_ECOLI UniProtKB-AC P0AB61 http://www.uniprot.org/uniprot/P0AB61 charge swissprot:YCIN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCIN_ECOLI eggNOG ENOG4105RKX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105RKX eggNOG ENOG4111PJF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111PJF epestfind swissprot:YCIN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCIN_ECOLI garnier swissprot:YCIN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCIN_ECOLI helixturnhelix swissprot:YCIN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCIN_ECOLI hmoment swissprot:YCIN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCIN_ECOLI iep swissprot:YCIN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCIN_ECOLI inforesidue swissprot:YCIN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCIN_ECOLI octanol swissprot:YCIN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCIN_ECOLI pepcoil swissprot:YCIN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCIN_ECOLI pepdigest swissprot:YCIN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCIN_ECOLI pepinfo swissprot:YCIN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCIN_ECOLI pepnet swissprot:YCIN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCIN_ECOLI pepstats swissprot:YCIN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCIN_ECOLI pepwheel swissprot:YCIN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCIN_ECOLI pepwindow swissprot:YCIN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCIN_ECOLI sigcleave swissprot:YCIN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCIN_ECOLI ## Database ID URL or Descriptions # EcoGene EG12978 yggR # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0006810 transport; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # Gene3D 3.40.50.300 -; 1. # INTERACTION YGGR_ECOLI P21599 pykA; NbExp=3; IntAct=EBI-552531, EBI-368956; # IntAct P52052 4 # InterPro IPR001482 T2SS_protein-E # InterPro IPR003593 AAA+_ATPase # InterPro IPR006321 PilT # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Brite ko02044 Secretion system # Organism YGGR_ECOLI Escherichia coli (strain K12) # PATRIC 32121312 VBIEscCol129921_3044 # PIR E65080 E65080 # PROSITE PS00662 T2SP_E # Pfam PF00437 T2SSE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGGR_ECOLI Uncharacterized protein YggR # RefSeq NP_417425 NC_000913.3 # RefSeq WP_001326494 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA69117.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the GSP E family. {ECO 0000305}. # SMART SM00382 AAA # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR01420 pilT_fam # eggNOG COG2805 LUCA # eggNOG ENOG4105CZX Bacteria BLAST swissprot:YGGR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGGR_ECOLI BioCyc ECOL316407:JW2917-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2917-MONOMER BioCyc EcoCyc:G7526-MONOMER http://biocyc.org/getid?id=EcoCyc:G7526-MONOMER COG COG2805 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2805 DIP DIP-12193N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12193N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2803 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2803 EcoGene EG12978 http://www.ecogene.org/geneInfo.php?eg_id=EG12978 EnsemblBacteria AAC75987 http://www.ensemblgenomes.org/id/AAC75987 EnsemblBacteria AAC75987 http://www.ensemblgenomes.org/id/AAC75987 EnsemblBacteria BAE77013 http://www.ensemblgenomes.org/id/BAE77013 EnsemblBacteria BAE77013 http://www.ensemblgenomes.org/id/BAE77013 EnsemblBacteria BAE77013 http://www.ensemblgenomes.org/id/BAE77013 EnsemblBacteria b2950 http://www.ensemblgenomes.org/id/b2950 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947430 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947430 HOGENOM HOG000008425 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000008425&db=HOGENOM6 InParanoid P52052 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P52052 IntAct P52052 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P52052* InterPro IPR001482 http://www.ebi.ac.uk/interpro/entry/IPR001482 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR006321 http://www.ebi.ac.uk/interpro/entry/IPR006321 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW2917 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2917 KEGG_Gene eco:b2950 http://www.genome.jp/dbget-bin/www_bget?eco:b2950 KEGG_Orthology KO:K02669 http://www.genome.jp/dbget-bin/www_bget?KO:K02669 MINT MINT-1260255 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1260255 OMA SERCLIQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SERCLIQ PROSITE PS00662 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00662 PSORT swissprot:YGGR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGGR_ECOLI PSORT-B swissprot:YGGR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGGR_ECOLI PSORT2 swissprot:YGGR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGGR_ECOLI Pfam PF00437 http://pfam.xfam.org/family/PF00437 Phobius swissprot:YGGR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGGR_ECOLI PhylomeDB P52052 http://phylomedb.org/?seqid=P52052 ProteinModelPortal P52052 http://www.proteinmodelportal.org/query/uniprot/P52052 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417425 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417425 RefSeq WP_001326494 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001326494 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P52052 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P52052 STRING 511145.b2950 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2950&targetmode=cogs STRING COG2805 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2805&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR01420 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01420 UniProtKB YGGR_ECOLI http://www.uniprot.org/uniprot/YGGR_ECOLI UniProtKB-AC P52052 http://www.uniprot.org/uniprot/P52052 charge swissprot:YGGR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGGR_ECOLI eggNOG COG2805 http://eggnogapi.embl.de/nog_data/html/tree/COG2805 eggNOG ENOG4105CZX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CZX epestfind swissprot:YGGR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGGR_ECOLI garnier swissprot:YGGR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGGR_ECOLI helixturnhelix swissprot:YGGR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGGR_ECOLI hmoment swissprot:YGGR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGGR_ECOLI iep swissprot:YGGR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGGR_ECOLI inforesidue swissprot:YGGR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGGR_ECOLI octanol swissprot:YGGR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGGR_ECOLI pepcoil swissprot:YGGR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGGR_ECOLI pepdigest swissprot:YGGR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGGR_ECOLI pepinfo swissprot:YGGR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGGR_ECOLI pepnet swissprot:YGGR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGGR_ECOLI pepstats swissprot:YGGR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGGR_ECOLI pepwheel swissprot:YGGR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGGR_ECOLI pepwindow swissprot:YGGR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGGR_ECOLI sigcleave swissprot:YGGR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGGR_ECOLI ## Database ID URL or Descriptions # AltName NANT_ECOLI Sialic acid permease # BioGrid 4262439 9 # CDD cd06174 MFS # EcoGene EG20145 nanT # FUNCTION NANT_ECOLI May be a sugar-cation symporter involved in sialic acid transport as it is required for sialic acid uptake. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015136 sialic acid transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0046943 carboxylic acid transmembrane transporter activity; IBA:GO_Central. # GO_function NANT_ECOLI GO 0005351 sugar proton symporter activity; IDA EcoCyc. # GO_function NANT_ECOLI GO 0015538 sialic acid proton symporter activity; IEA UniProtKB-HAMAP. # GO_process GO:0015739 sialic acid transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # HAMAP MF_01238 MFS_NanT # INDUCTION NANT_ECOLI By N-acetylneuraminate. # InterPro IPR004742 SA_transporter # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # KEGG_Brite ko02000 Transporters # Organism NANT_ECOLI Escherichia coli (strain K12) # PATRIC 32121872 VBIEscCol129921_3320 # PIR B65114 B65114 # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NANT_ECOLI Putative sialic acid transporter # RefSeq NP_417691 NC_000913.3 # RefSeq WP_000108454 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA58026.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAA86827.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Sialic acid transporter (TC 2.A.1.12.1) subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION NANT_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF103473 SSF103473; 2 # TCDB 2.A.1.12 the major facilitator superfamily (mfs) # TIGRFAMs TIGR00891 2A0112 # eggNOG ENOG4105JHE Bacteria # eggNOG ENOG410XSSD LUCA BLAST swissprot:NANT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NANT_ECOLI BioCyc ECOL316407:JW3193-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3193-MONOMER BioCyc EcoCyc:NANT-MONOMER http://biocyc.org/getid?id=EcoCyc:NANT-MONOMER BioCyc MetaCyc:NANT-MONOMER http://biocyc.org/getid?id=MetaCyc:NANT-MONOMER COG COG0477 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0477 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D00067 http://www.ebi.ac.uk/ena/data/view/D00067 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL U19539 http://www.ebi.ac.uk/ena/data/view/U19539 EchoBASE EB4145 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4145 EcoGene EG20145 http://www.ecogene.org/geneInfo.php?eg_id=EG20145 EnsemblBacteria AAC76256 http://www.ensemblgenomes.org/id/AAC76256 EnsemblBacteria AAC76256 http://www.ensemblgenomes.org/id/AAC76256 EnsemblBacteria BAE77267 http://www.ensemblgenomes.org/id/BAE77267 EnsemblBacteria BAE77267 http://www.ensemblgenomes.org/id/BAE77267 EnsemblBacteria BAE77267 http://www.ensemblgenomes.org/id/BAE77267 EnsemblBacteria b3224 http://www.ensemblgenomes.org/id/b3224 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005351 GO_function GO:0015136 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015136 GO_function GO:0015538 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015538 GO_function GO:0046943 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046943 GO_process GO:0015739 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015739 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 947740 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947740 HAMAP MF_01238 http://hamap.expasy.org/unirule/MF_01238 HOGENOM HOG000074791 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000074791&db=HOGENOM6 InParanoid P41036 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P41036 InterPro IPR004742 http://www.ebi.ac.uk/interpro/entry/IPR004742 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3193 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3193 KEGG_Gene eco:b3224 http://www.genome.jp/dbget-bin/www_bget?eco:b3224 KEGG_Orthology KO:K03290 http://www.genome.jp/dbget-bin/www_bget?KO:K03290 OMA IGYLLDG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IGYLLDG PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:NANT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NANT_ECOLI PSORT-B swissprot:NANT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NANT_ECOLI PSORT2 swissprot:NANT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NANT_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:NANT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NANT_ECOLI PhylomeDB P41036 http://phylomedb.org/?seqid=P41036 ProteinModelPortal P41036 http://www.proteinmodelportal.org/query/uniprot/P41036 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7592358 http://www.ncbi.nlm.nih.gov/pubmed/7592358 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417691 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417691 RefSeq WP_000108454 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000108454 STRING 511145.b3224 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3224&targetmode=cogs STRING COG0477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0477&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.12 http://www.tcdb.org/search/result.php?tc=2.A.1.12 TIGRFAMs TIGR00891 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00891 UniProtKB NANT_ECOLI http://www.uniprot.org/uniprot/NANT_ECOLI UniProtKB-AC P41036 http://www.uniprot.org/uniprot/P41036 charge swissprot:NANT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NANT_ECOLI eggNOG ENOG4105JHE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105JHE eggNOG ENOG410XSSD http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XSSD epestfind swissprot:NANT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NANT_ECOLI garnier swissprot:NANT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NANT_ECOLI helixturnhelix swissprot:NANT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NANT_ECOLI hmoment swissprot:NANT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NANT_ECOLI iep swissprot:NANT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NANT_ECOLI inforesidue swissprot:NANT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NANT_ECOLI octanol swissprot:NANT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NANT_ECOLI pepcoil swissprot:NANT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NANT_ECOLI pepdigest swissprot:NANT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NANT_ECOLI pepinfo swissprot:NANT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NANT_ECOLI pepnet swissprot:NANT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NANT_ECOLI pepstats swissprot:NANT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NANT_ECOLI pepwheel swissprot:NANT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NANT_ECOLI pepwindow swissprot:NANT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NANT_ECOLI sigcleave swissprot:NANT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NANT_ECOLI ## Database ID URL or Descriptions # BioGrid 4263475 6 # DISRUPTION PHENOTYPE Cells undergo an apoptotic-like death upon DNA damage characterized by membrane depolarization; further disruption of recA prevents membrane depolarization. {ECO:0000269|PubMed 22412352}. # EcoGene EG11784 grcA # FUNCTION GRCA_ECOLI Acts as a radical domain for damaged PFL and possibly other radical proteins. {ECO 0000269|PubMed 11444864}. # GO_component GO:0005737 cytoplasm; IDA:UniProtKB. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003824 catalytic activity; IEA:InterPro. # GO_process GO:0006567 threonine catabolic process; IBA:GO_Central. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # HAMAP MF_00806 GrcA # INDUCTION By acid stress. {ECO:0000269|PubMed 11932447}. # IntAct P68066 12 # InterPro IPR001150 Gly_radical # InterPro IPR011140 Glycyl_radical_cofactor_GrcA # InterPro IPR019777 Form_AcTrfase_GR_CS # Organism GRCA_ECOLI Escherichia coli (strain K12) # PATRIC 32120559 VBIEscCol129921_2682 # PIR B65036 B65036 # PIRSF PIRSF000378 Gly_radicl_yfiD # PROSITE PS00850 GLY_RADICAL_1 # PROSITE PS51149 GLY_RADICAL_2 # Pfam PF01228 Gly_radical # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GRCA_ECOLI Autonomous glycyl radical cofactor # RefSeq NP_417074 NC_000913.3 # RefSeq WP_000627807 NZ_LN832404.1 # SIMILARITY Contains 1 glycine radical domain. {ECO 0000305}. # TIGRFAMs TIGR04365 spare_glycyl # eggNOG COG3445 LUCA # eggNOG ENOG4108VKA Bacteria BLAST swissprot:GRCA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GRCA_ECOLI BioCyc ECOL316407:JW2563-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2563-MONOMER BioCyc EcoCyc:EG11784-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11784-MONOMER COG COG3445 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3445 DIP DIP-47913N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47913N DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1006/bbrc.2001.5186 http://dx.doi.org/10.1006/bbrc.2001.5186 DOI 10.1006/jmbi.1998.1726 http://dx.doi.org/10.1006/jmbi.1998.1726 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1111/j.1574-6968.1998.tb13343.x http://dx.doi.org/10.1111/j.1574-6968.1998.tb13343.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pbio.1001281 http://dx.doi.org/10.1371/journal.pbio.1001281 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D13169 http://www.ebi.ac.uk/ena/data/view/D13169 EMBL D64044 http://www.ebi.ac.uk/ena/data/view/D64044 EMBL J03725 http://www.ebi.ac.uk/ena/data/view/J03725 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1732 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1732 EcoGene EG11784 http://www.ecogene.org/geneInfo.php?eg_id=EG11784 EnsemblBacteria AAC75632 http://www.ensemblgenomes.org/id/AAC75632 EnsemblBacteria AAC75632 http://www.ensemblgenomes.org/id/AAC75632 EnsemblBacteria BAA16465 http://www.ensemblgenomes.org/id/BAA16465 EnsemblBacteria BAA16465 http://www.ensemblgenomes.org/id/BAA16465 EnsemblBacteria BAA16465 http://www.ensemblgenomes.org/id/BAA16465 EnsemblBacteria b2579 http://www.ensemblgenomes.org/id/b2579 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003824 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003824 GO_process GO:0006567 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006567 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GeneID 947068 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947068 HAMAP MF_00806 http://hamap.expasy.org/unirule/MF_00806 HOGENOM HOG000281256 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000281256&db=HOGENOM6 IntAct P68066 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P68066* InterPro IPR001150 http://www.ebi.ac.uk/interpro/entry/IPR001150 InterPro IPR011140 http://www.ebi.ac.uk/interpro/entry/IPR011140 InterPro IPR019777 http://www.ebi.ac.uk/interpro/entry/IPR019777 KEGG_Gene ecj:JW2563 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2563 KEGG_Gene eco:b2579 http://www.genome.jp/dbget-bin/www_bget?eco:b2579 KEGG_Orthology KO:K06866 http://www.genome.jp/dbget-bin/www_bget?KO:K06866 OMA GQFEYRE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GQFEYRE PROSITE PS00850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00850 PROSITE PS51149 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51149 PSORT swissprot:GRCA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GRCA_ECOLI PSORT-B swissprot:GRCA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GRCA_ECOLI PSORT2 swissprot:GRCA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GRCA_ECOLI Pfam PF01228 http://pfam.xfam.org/family/PF01228 Phobius swissprot:GRCA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GRCA_ECOLI ProteinModelPortal P68066 http://www.proteinmodelportal.org/query/uniprot/P68066 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 11444864 http://www.ncbi.nlm.nih.gov/pubmed/11444864 PubMed 11932447 http://www.ncbi.nlm.nih.gov/pubmed/11932447 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 22412352 http://www.ncbi.nlm.nih.gov/pubmed/22412352 PubMed 2836397 http://www.ncbi.nlm.nih.gov/pubmed/2836397 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 PubMed 9868784 http://www.ncbi.nlm.nih.gov/pubmed/9868784 RefSeq NP_417074 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417074 RefSeq WP_000627807 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000627807 SMR P68066 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P68066 STRING 511145.b2579 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2579&targetmode=cogs STRING COG3445 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3445&targetmode=cogs SWISS-2DPAGE P68066 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P68066 TIGRFAMs TIGR04365 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR04365 UniProtKB GRCA_ECOLI http://www.uniprot.org/uniprot/GRCA_ECOLI UniProtKB-AC P68066 http://www.uniprot.org/uniprot/P68066 charge swissprot:GRCA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GRCA_ECOLI eggNOG COG3445 http://eggnogapi.embl.de/nog_data/html/tree/COG3445 eggNOG ENOG4108VKA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108VKA epestfind swissprot:GRCA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GRCA_ECOLI garnier swissprot:GRCA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GRCA_ECOLI helixturnhelix swissprot:GRCA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GRCA_ECOLI hmoment swissprot:GRCA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GRCA_ECOLI iep swissprot:GRCA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GRCA_ECOLI inforesidue swissprot:GRCA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GRCA_ECOLI octanol swissprot:GRCA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GRCA_ECOLI pepcoil swissprot:GRCA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GRCA_ECOLI pepdigest swissprot:GRCA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GRCA_ECOLI pepinfo swissprot:GRCA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GRCA_ECOLI pepnet swissprot:GRCA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GRCA_ECOLI pepstats swissprot:GRCA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GRCA_ECOLI pepwheel swissprot:GRCA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GRCA_ECOLI pepwindow swissprot:GRCA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GRCA_ECOLI sigcleave swissprot:GRCA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GRCA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260675 294 # CAZy GT4 Glycosyltransferase Family 4 # EcoGene EG13571 wcaC # GO_function GO:0016740 transferase activity; IEA:UniProtKB-KW. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0045228 slime layer polysaccharide biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # IntAct P71237 6 # InterPro IPR001296 Glyco_trans_1 # InterPro IPR023916 Colanic_acid_synth_WcaC # InterPro IPR028098 Glyco_trans_4-like_N # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01003 Glycosyltransferases # Organism WCAC_ECOLI Escherichia coli (strain K12) # PATHWAY WCAC_ECOLI Slime biogenesis; slime polysaccharide biosynthesis. # PATRIC 32119447 VBIEscCol129921_2134 # PIR H64971 H64971 # Pfam PF00534 Glycos_transf_1 # Pfam PF13439 Glyco_transf_4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName WCAC_ECOLI Putative colanic acid biosynthesis glycosyl transferase WcaC # RefSeq NP_416561 NC_000913.3 # RefSeq WP_001023871 NZ_LN832404.1 # TIGRFAMs TIGR04015 WcaC # eggNOG COG0438 LUCA # eggNOG ENOG4107RXY Bacteria BLAST swissprot:WCAC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:WCAC_ECOLI BioCyc ECOL316407:JW2042-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2042-MONOMER BioCyc EcoCyc:G7102-MONOMER http://biocyc.org/getid?id=EcoCyc:G7102-MONOMER COG CAZy: http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=CAZy: COG COG0438 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0438 COG GT4 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=GT4 DIP DIP-11119N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11119N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U38473 http://www.ebi.ac.uk/ena/data/view/U38473 EchoBASE EB3341 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3341 EcoGene EG13571 http://www.ecogene.org/geneInfo.php?eg_id=EG13571 EnsemblBacteria AAC75118 http://www.ensemblgenomes.org/id/AAC75118 EnsemblBacteria AAC75118 http://www.ensemblgenomes.org/id/AAC75118 EnsemblBacteria BAE76574 http://www.ensemblgenomes.org/id/BAE76574 EnsemblBacteria BAE76574 http://www.ensemblgenomes.org/id/BAE76574 EnsemblBacteria BAE76574 http://www.ensemblgenomes.org/id/BAE76574 EnsemblBacteria b2057 http://www.ensemblgenomes.org/id/b2057 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016740 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016740 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GO_process GO:0045228 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045228 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 946579 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946579 HOGENOM HOG000121966 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000121966&db=HOGENOM6 InParanoid P71237 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P71237 IntAct P71237 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P71237* InterPro IPR001296 http://www.ebi.ac.uk/interpro/entry/IPR001296 InterPro IPR023916 http://www.ebi.ac.uk/interpro/entry/IPR023916 InterPro IPR028098 http://www.ebi.ac.uk/interpro/entry/IPR028098 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01003 http://www.genome.jp/dbget-bin/www_bget?ko01003 KEGG_Gene ecj:JW2042 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2042 KEGG_Gene eco:b2057 http://www.genome.jp/dbget-bin/www_bget?eco:b2057 KEGG_Orthology KO:K13684 http://www.genome.jp/dbget-bin/www_bget?KO:K13684 MINT MINT-1255947 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1255947 OMA VKVDRAH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VKVDRAH PSORT swissprot:WCAC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:WCAC_ECOLI PSORT-B swissprot:WCAC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:WCAC_ECOLI PSORT2 swissprot:WCAC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:WCAC_ECOLI Pfam PF00534 http://pfam.xfam.org/family/PF00534 Pfam PF13439 http://pfam.xfam.org/family/PF13439 Phobius swissprot:WCAC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:WCAC_ECOLI PhylomeDB P71237 http://phylomedb.org/?seqid=P71237 ProteinModelPortal P71237 http://www.proteinmodelportal.org/query/uniprot/P71237 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8759852 http://www.ncbi.nlm.nih.gov/pubmed/8759852 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416561 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416561 RefSeq WP_001023871 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001023871 STRING 511145.b2057 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2057&targetmode=cogs STRING CAZy: http://string-db.org/newstring_cgi/show_network_section.pl?identifier=CAZy:&targetmode=cogs STRING COG0438 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0438&targetmode=cogs STRING GT4 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=GT4&targetmode=cogs TIGRFAMs TIGR04015 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR04015 UniProtKB WCAC_ECOLI http://www.uniprot.org/uniprot/WCAC_ECOLI UniProtKB-AC P71237 http://www.uniprot.org/uniprot/P71237 charge swissprot:WCAC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:WCAC_ECOLI eggNOG COG0438 http://eggnogapi.embl.de/nog_data/html/tree/COG0438 eggNOG ENOG4107RXY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107RXY epestfind swissprot:WCAC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:WCAC_ECOLI garnier swissprot:WCAC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:WCAC_ECOLI helixturnhelix swissprot:WCAC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:WCAC_ECOLI hmoment swissprot:WCAC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:WCAC_ECOLI iep swissprot:WCAC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:WCAC_ECOLI inforesidue swissprot:WCAC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:WCAC_ECOLI octanol swissprot:WCAC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:WCAC_ECOLI pepcoil swissprot:WCAC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:WCAC_ECOLI pepdigest swissprot:WCAC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:WCAC_ECOLI pepinfo swissprot:WCAC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:WCAC_ECOLI pepnet swissprot:WCAC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:WCAC_ECOLI pepstats swissprot:WCAC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:WCAC_ECOLI pepwheel swissprot:WCAC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:WCAC_ECOLI pepwindow swissprot:WCAC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:WCAC_ECOLI sigcleave swissprot:WCAC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:WCAC_ECOLI ## Database ID URL or Descriptions # BioGrid 4259393 2 # EcoGene EG13196 yfjJ # IntAct P52125 6 # Organism YFJJ_ECOLI Escherichia coli (strain K12) # PIR D65041 D65041 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFJJ_ECOLI Uncharacterized protein YfjJ # RefSeq NP_417115 NC_000913.3 # RefSeq WP_000220524 NZ_LN832404.1 # SIMILARITY To E.coli YagK. {ECO 0000305}. # eggNOG ENOG4105H5P Bacteria # eggNOG ENOG4111NRD LUCA BLAST swissprot:YFJJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFJJ_ECOLI BioCyc ECOL316407:JW2607-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2607-MONOMER BioCyc EcoCyc:G7361-MONOMER http://biocyc.org/getid?id=EcoCyc:G7361-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36840 http://www.ebi.ac.uk/ena/data/view/U36840 EchoBASE EB2988 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2988 EcoGene EG13196 http://www.ecogene.org/geneInfo.php?eg_id=EG13196 EnsemblBacteria AAC75674 http://www.ensemblgenomes.org/id/AAC75674 EnsemblBacteria AAC75674 http://www.ensemblgenomes.org/id/AAC75674 EnsemblBacteria BAE76761 http://www.ensemblgenomes.org/id/BAE76761 EnsemblBacteria BAE76761 http://www.ensemblgenomes.org/id/BAE76761 EnsemblBacteria BAE76761 http://www.ensemblgenomes.org/id/BAE76761 EnsemblBacteria b2626 http://www.ensemblgenomes.org/id/b2626 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947112 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947112 HOGENOM HOG000290900 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000290900&db=HOGENOM6 IntAct P52125 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P52125* KEGG_Gene ecj:JW2607 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2607 KEGG_Gene eco:b2626 http://www.genome.jp/dbget-bin/www_bget?eco:b2626 OMA EERSFGC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EERSFGC PSORT swissprot:YFJJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFJJ_ECOLI PSORT-B swissprot:YFJJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFJJ_ECOLI PSORT2 swissprot:YFJJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFJJ_ECOLI Phobius swissprot:YFJJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFJJ_ECOLI ProteinModelPortal P52125 http://www.proteinmodelportal.org/query/uniprot/P52125 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417115 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417115 RefSeq WP_000220524 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000220524 STRING 511145.b2626 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2626&targetmode=cogs UniProtKB YFJJ_ECOLI http://www.uniprot.org/uniprot/YFJJ_ECOLI UniProtKB-AC P52125 http://www.uniprot.org/uniprot/P52125 charge swissprot:YFJJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFJJ_ECOLI eggNOG ENOG4105H5P http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105H5P eggNOG ENOG4111NRD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111NRD epestfind swissprot:YFJJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFJJ_ECOLI garnier swissprot:YFJJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFJJ_ECOLI helixturnhelix swissprot:YFJJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFJJ_ECOLI hmoment swissprot:YFJJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFJJ_ECOLI iep swissprot:YFJJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFJJ_ECOLI inforesidue swissprot:YFJJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFJJ_ECOLI octanol swissprot:YFJJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFJJ_ECOLI pepcoil swissprot:YFJJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFJJ_ECOLI pepdigest swissprot:YFJJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFJJ_ECOLI pepinfo swissprot:YFJJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFJJ_ECOLI pepnet swissprot:YFJJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFJJ_ECOLI pepstats swissprot:YFJJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFJJ_ECOLI pepwheel swissprot:YFJJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFJJ_ECOLI pepwindow swissprot:YFJJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFJJ_ECOLI sigcleave swissprot:YFJJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFJJ_ECOLI ## Database ID URL or Descriptions # AltName 4-(2'-carboxyphenyl)-4-oxybutyric acid synthase {ECO:0000255|HAMAP-Rule MF_00470, ECO:0000305} # AltName o-succinylbenzoic acid synthase {ECO:0000255|HAMAP-Rule MF_00470, ECO:0000305} # BRENDA 4.2.1.113 2026 # BioGrid 4260503 22 # CATALYTIC ACTIVITY MENC_ECOLI (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4- diene-1-carboxylate = 2-succinylbenzoate + H(2)O. {ECO 0000255|HAMAP-Rule MF_00470, ECO 0000269|PubMed 10194342, ECO 0000269|PubMed 8335646}. # COFACTOR MENC_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 10978150}; # EcoGene EG11532 menC # FUNCTION MENC_ECOLI Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). {ECO 0000255|HAMAP-Rule MF_00470, ECO 0000269|PubMed 10194342, ECO 0000269|PubMed 8335646}. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0016836 hydro-lyase activity; IDA:EcoCyc. # GO_process GO:0009234 menaquinone biosynthetic process; IMP:EcoCyc. # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.20.20.120 -; 1. # Gene3D 3.30.390.10 -; 1. # HAMAP MF_00470 MenC_1 # IntAct P29208 5 # InterPro IPR001354 MR/MLE/MAL # InterPro IPR010196 OSB_synthase_MenC1 # InterPro IPR010197 OSB_synthase_MenC_2 # InterPro IPR013342 Mandelate_racemase_C # InterPro IPR029017 Enolase_N-like # InterPro IPR029065 Enolase_C-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00130 Ubiquinone and other terpenoid-quinone biosynthesis # Organism MENC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR13794 PTHR13794 # PANTHER PTHR13794:SF8 PTHR13794:SF8 # PATHWAY MENC_ECOLI Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate step 4/7. {ECO 0000255|HAMAP-Rule MF_00470, ECO 0000269|PubMed 8335646}. # PATHWAY MENC_ECOLI Quinol/quinone metabolism; menaquinone biosynthesis. {ECO 0000255|HAMAP-Rule MF_00470, ECO 0000269|PubMed 8335646}. # PATRIC 32119889 VBIEscCol129921_2354 # PDB 1FHU X-ray; 1.65 A; A=1-320 # PDB 1FHV X-ray; 1.77 A; A=1-320 # PDB 1R6W X-ray; 1.62 A; A=1-320 # PDB 2OFJ X-ray; 2.30 A; A/B/C/D=1-320 # PIR C64997 C64997 # Pfam PF13378 MR_MLE_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MENC_ECOLI o-succinylbenzoate synthase {ECO 0000255|HAMAP-Rule MF_00470, ECO 0000303|PubMed 8335646} # RefSeq NP_416764 NC_000913.3 # RefSeq WP_001255628 NZ_LN832404.1 # SIMILARITY Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily. {ECO:0000255|HAMAP- Rule MF_00470, ECO:0000305}. # SMART SM00922 MR_MLE # SUPFAM SSF51604 SSF51604 # SUPFAM SSF54826 SSF54826 # UniPathway UPA01057 UER00165 # eggNOG COG1441 LUCA # eggNOG ENOG4105DNI Bacteria BLAST swissprot:MENC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MENC_ECOLI BioCyc ECOL316407:JW2256-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2256-MONOMER BioCyc EcoCyc:O-SUCCINYLBENZOATE-COA-SYN-MONOMER http://biocyc.org/getid?id=EcoCyc:O-SUCCINYLBENZOATE-COA-SYN-MONOMER BioCyc MetaCyc:O-SUCCINYLBENZOATE-COA-SYN-MONOMER http://biocyc.org/getid?id=MetaCyc:O-SUCCINYLBENZOATE-COA-SYN-MONOMER COG COG1441 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1441 DOI 10.1021/bi000855o http://dx.doi.org/10.1021/bi000855o DOI 10.1021/bi990140p http://dx.doi.org/10.1021/bi990140p DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.1.113 {ECO:0000255|HAMAP-Rule:MF_00470, ECO:0000269|PubMed:10194342, ECO:0000269|PubMed:8335646} http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.113 {ECO:0000255|HAMAP-Rule:MF_00470, ECO:0000269|PubMed:10194342, ECO:0000269|PubMed:8335646} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L07256 http://www.ebi.ac.uk/ena/data/view/L07256 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 4.2.1.113 {ECO:0000255|HAMAP-Rule:MF_00470, ECO:0000269|PubMed:10194342, ECO:0000269|PubMed:8335646} http://enzyme.expasy.org/EC/4.2.1.113 {ECO:0000255|HAMAP-Rule:MF_00470, ECO:0000269|PubMed:10194342, ECO:0000269|PubMed:8335646} EchoBASE EB1494 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1494 EcoGene EG11532 http://www.ecogene.org/geneInfo.php?eg_id=EG11532 EnsemblBacteria AAC75321 http://www.ensemblgenomes.org/id/AAC75321 EnsemblBacteria AAC75321 http://www.ensemblgenomes.org/id/AAC75321 EnsemblBacteria BAA16085 http://www.ensemblgenomes.org/id/BAA16085 EnsemblBacteria BAA16085 http://www.ensemblgenomes.org/id/BAA16085 EnsemblBacteria BAA16085 http://www.ensemblgenomes.org/id/BAA16085 EnsemblBacteria b2261 http://www.ensemblgenomes.org/id/b2261 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0016836 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016836 GO_process GO:0009234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009234 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.20.20.120 http://www.cathdb.info/version/latest/superfamily/3.20.20.120 Gene3D 3.30.390.10 http://www.cathdb.info/version/latest/superfamily/3.30.390.10 GeneID 946734 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946734 HAMAP MF_00470 http://hamap.expasy.org/unirule/MF_00470 HOGENOM HOG000271247 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000271247&db=HOGENOM6 InParanoid P29208 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P29208 IntAct P29208 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P29208* IntEnz 4.2.1.113 {ECO:0000255|HAMAP-Rule:MF_00470, ECO:0000269|PubMed:10194342, ECO:0000269|PubMed:8335646} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.113 {ECO:0000255|HAMAP-Rule:MF_00470, ECO:0000269|PubMed:10194342, ECO:0000269|PubMed:8335646} InterPro IPR001354 http://www.ebi.ac.uk/interpro/entry/IPR001354 InterPro IPR010196 http://www.ebi.ac.uk/interpro/entry/IPR010196 InterPro IPR010197 http://www.ebi.ac.uk/interpro/entry/IPR010197 InterPro IPR013342 http://www.ebi.ac.uk/interpro/entry/IPR013342 InterPro IPR029017 http://www.ebi.ac.uk/interpro/entry/IPR029017 InterPro IPR029065 http://www.ebi.ac.uk/interpro/entry/IPR029065 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2256 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2256 KEGG_Gene eco:b2261 http://www.genome.jp/dbget-bin/www_bget?eco:b2261 KEGG_Orthology KO:K02549 http://www.genome.jp/dbget-bin/www_bget?KO:K02549 KEGG_Pathway ko00130 http://www.genome.jp/kegg-bin/show_pathway?ko00130 KEGG_Reaction rn:R04031 http://www.genome.jp/dbget-bin/www_bget?rn:R04031 MINT MINT-1305669 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1305669 OMA YEANRDG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YEANRDG PANTHER PTHR13794 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13794 PANTHER PTHR13794:SF8 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13794:SF8 PDB 1FHU http://www.ebi.ac.uk/pdbe-srv/view/entry/1FHU PDB 1FHV http://www.ebi.ac.uk/pdbe-srv/view/entry/1FHV PDB 1R6W http://www.ebi.ac.uk/pdbe-srv/view/entry/1R6W PDB 2OFJ http://www.ebi.ac.uk/pdbe-srv/view/entry/2OFJ PDBsum 1FHU http://www.ebi.ac.uk/pdbsum/1FHU PDBsum 1FHV http://www.ebi.ac.uk/pdbsum/1FHV PDBsum 1R6W http://www.ebi.ac.uk/pdbsum/1R6W PDBsum 2OFJ http://www.ebi.ac.uk/pdbsum/2OFJ PSORT swissprot:MENC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MENC_ECOLI PSORT-B swissprot:MENC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MENC_ECOLI PSORT2 swissprot:MENC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MENC_ECOLI Pfam PF13378 http://pfam.xfam.org/family/PF13378 Phobius swissprot:MENC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MENC_ECOLI PhylomeDB P29208 http://phylomedb.org/?seqid=P29208 ProteinModelPortal P29208 http://www.proteinmodelportal.org/query/uniprot/P29208 PubMed 10194342 http://www.ncbi.nlm.nih.gov/pubmed/10194342 PubMed 10978150 http://www.ncbi.nlm.nih.gov/pubmed/10978150 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8335646 http://www.ncbi.nlm.nih.gov/pubmed/8335646 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416764 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416764 RefSeq WP_001255628 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001255628 SMART SM00922 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00922 SMR P29208 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P29208 STRING 511145.b2261 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2261&targetmode=cogs STRING COG1441 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1441&targetmode=cogs SUPFAM SSF51604 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51604 SUPFAM SSF54826 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54826 UniProtKB MENC_ECOLI http://www.uniprot.org/uniprot/MENC_ECOLI UniProtKB-AC P29208 http://www.uniprot.org/uniprot/P29208 charge swissprot:MENC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MENC_ECOLI eggNOG COG1441 http://eggnogapi.embl.de/nog_data/html/tree/COG1441 eggNOG ENOG4105DNI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DNI epestfind swissprot:MENC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MENC_ECOLI garnier swissprot:MENC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MENC_ECOLI helixturnhelix swissprot:MENC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MENC_ECOLI hmoment swissprot:MENC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MENC_ECOLI iep swissprot:MENC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MENC_ECOLI inforesidue swissprot:MENC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MENC_ECOLI octanol swissprot:MENC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MENC_ECOLI pepcoil swissprot:MENC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MENC_ECOLI pepdigest swissprot:MENC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MENC_ECOLI pepinfo swissprot:MENC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MENC_ECOLI pepnet swissprot:MENC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MENC_ECOLI pepstats swissprot:MENC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MENC_ECOLI pepwheel swissprot:MENC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MENC_ECOLI pepwindow swissprot:MENC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MENC_ECOLI sigcleave swissprot:MENC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MENC_ECOLI ## Database ID URL or Descriptions # BioGrid 4260588 4 # EcoGene EG14209 yfgM # GO_component GO:0043234 protein complex; IPI:EcoCyc. # GO_component GO:0071575 integral component of external side of plasma membrane; IDA:EcoCyc. # GO_function GO:0032403 protein complex binding; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # Gene3D 1.25.40.10 -; 1. # IntAct P76576 5 # InterPro IPR011990 TPR-like_helical_dom # InterPro IPR018704 TPR_21 # InterPro IPR026039 UPF0070 # Organism YFGM_ECOLI Escherichia coli (strain K12) # PATRIC 32120419 VBIEscCol129921_2612 # PIR H65027 H65027 # PIRSF PIRSF006170 YfgM # Pfam PF09976 TPR_21 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFGM_ECOLI UPF0070 protein YfgM # RefSeq NP_417008 NC_000913.3 # RefSeq WP_000409205 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0070 family. {ECO 0000305}. # SUBCELLULAR LOCATION YFGM_ECOLI Membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. # SUPFAM SSF48452 SSF48452 # eggNOG COG2976 LUCA # eggNOG ENOG4105N21 Bacteria BLAST swissprot:YFGM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFGM_ECOLI BioCyc ECOL316407:JW2497-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2497-MONOMER BioCyc EcoCyc:G7321-MONOMER http://biocyc.org/getid?id=EcoCyc:G7321-MONOMER DIP DIP-12043N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12043N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3961 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3961 EcoGene EG14209 http://www.ecogene.org/geneInfo.php?eg_id=EG14209 EnsemblBacteria AAC75566 http://www.ensemblgenomes.org/id/AAC75566 EnsemblBacteria AAC75566 http://www.ensemblgenomes.org/id/AAC75566 EnsemblBacteria BAA16399 http://www.ensemblgenomes.org/id/BAA16399 EnsemblBacteria BAA16399 http://www.ensemblgenomes.org/id/BAA16399 EnsemblBacteria BAA16399 http://www.ensemblgenomes.org/id/BAA16399 EnsemblBacteria b2513 http://www.ensemblgenomes.org/id/b2513 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GO_component GO:0071575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071575 GO_function GO:0032403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032403 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 Gene3D 1.25.40.10 http://www.cathdb.info/version/latest/superfamily/1.25.40.10 GeneID 946981 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946981 HOGENOM HOG000261006 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261006&db=HOGENOM6 InParanoid P76576 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76576 IntAct P76576 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76576* InterPro IPR011990 http://www.ebi.ac.uk/interpro/entry/IPR011990 InterPro IPR018704 http://www.ebi.ac.uk/interpro/entry/IPR018704 InterPro IPR026039 http://www.ebi.ac.uk/interpro/entry/IPR026039 KEGG_Gene ecj:JW2497 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2497 KEGG_Gene eco:b2513 http://www.genome.jp/dbget-bin/www_bget?eco:b2513 OMA VGWRFWQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VGWRFWQ PSORT swissprot:YFGM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFGM_ECOLI PSORT-B swissprot:YFGM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFGM_ECOLI PSORT2 swissprot:YFGM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFGM_ECOLI Pfam PF09976 http://pfam.xfam.org/family/PF09976 Phobius swissprot:YFGM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFGM_ECOLI ProteinModelPortal P76576 http://www.proteinmodelportal.org/query/uniprot/P76576 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417008 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417008 RefSeq WP_000409205 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000409205 SMR P76576 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76576 STRING 511145.b2513 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2513&targetmode=cogs SUPFAM SSF48452 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48452 UniProtKB YFGM_ECOLI http://www.uniprot.org/uniprot/YFGM_ECOLI UniProtKB-AC P76576 http://www.uniprot.org/uniprot/P76576 charge swissprot:YFGM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFGM_ECOLI eggNOG COG2976 http://eggnogapi.embl.de/nog_data/html/tree/COG2976 eggNOG ENOG4105N21 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105N21 epestfind swissprot:YFGM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFGM_ECOLI garnier swissprot:YFGM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFGM_ECOLI helixturnhelix swissprot:YFGM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFGM_ECOLI hmoment swissprot:YFGM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFGM_ECOLI iep swissprot:YFGM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFGM_ECOLI inforesidue swissprot:YFGM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFGM_ECOLI octanol swissprot:YFGM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFGM_ECOLI pepcoil swissprot:YFGM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFGM_ECOLI pepdigest swissprot:YFGM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFGM_ECOLI pepinfo swissprot:YFGM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFGM_ECOLI pepnet swissprot:YFGM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFGM_ECOLI pepstats swissprot:YFGM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFGM_ECOLI pepwheel swissprot:YFGM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFGM_ECOLI pepwindow swissprot:YFGM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFGM_ECOLI sigcleave swissprot:YFGM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFGM_ECOLI ## Database ID URL or Descriptions # AltName DER_ECOLI Double era-like domain protein # AltName DER_ECOLI GTP-binding protein EngA # BIOPHYSICOCHEMICAL PROPERTIES DER_ECOLI Kinetic parameters KM=125 uM for GTP (to 143 uM) in the absence of YihI {ECO 0000269|PubMed 16930151, ECO 0000269|PubMed 20434458}; KM=59.2 uM for GTP in the presence of full-length YihI {ECO 0000269|PubMed 16930151, ECO 0000269|PubMed 20434458}; KM=50.1 uM for GTP in the presence of N-terminally truncated YihI {ECO 0000269|PubMed 16930151, ECO 0000269|PubMed 20434458}; Note=Vmax increases 35% in the presence of full length YihI and 90% in the presence of YihI missing the first 45 residues.; # BioGrid 4263153 14 # DISRUPTION PHENOTYPE DER_ECOLI Lethality. In a depletion experiment cells grow normally for 4 hours, at which time there is no detectable protein left. After 4 hours cell growth decreases rapidly, the amount of 50S ribosomal subunit decreases, rRNA precursors accumulate. A 40S ribosomal subunit is detected which is missing proteins L9 and L18 and has slightly reduced amounts of L2 and L6 compared to wild-type ribosomes. {ECO 0000269|PubMed 11387344, ECO 0000269|PubMed 16930151, ECO 0000269|PubMed 16963571}. # DOMAIN DER_ECOLI The 2 G (guanine nucleotide-binding) domains are essential for activity and function cooperatively. The KH-like domain is required for ribosome recognition. {ECO 0000269|PubMed 20172997}. # EcoGene EG14207 der # FUNCTION DER_ECOLI GTPase that plays an essential role in the late steps of ribosome biogenesis. GTPase point mutations (but not a deletion mutant) are suppressed by mild overexpression of RelA, probably due to increased levels of the stringent response mediator (p)ppGpp. 50S subunits assembled in the absence of Der are defective and unable to assemble into 70S ribosomes. GTPase activity is stimulated by YihI. Overexpression rescues an rrmJ deletion, stabilizing the 70S ribosome. Der and RrmJ are likely to share a mechanism to stabilize 50S ribosomal subunits at a very late stage of 50S subunit maturation possibly by interacting with 23S rRNA or 23S rRNA/r-protein complex. {ECO 0000269|PubMed 11976298, ECO 0000269|PubMed 16930151}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003924 GTPase activity; IDA:EcoCyc. # GO_function GO:0005525 GTP binding; IBA:GO_Central. # GO_function GO:0032794 GTPase activating protein binding; IPI:EcoCyc. # GO_function GO:0043022 ribosome binding; IDA:EcoCyc. # GO_process GO:0000027 ribosomal large subunit assembly; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003924 GTPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0022618 ribonucleoprotein complex assembly # Gene3D 3.30.300.20 -; 1. # Gene3D 3.40.50.300 -; 2. # HAMAP MF_00195 GTPase_Der # IntAct P0A6P5 7 # InterPro IPR005225 Small_GTP-bd_dom # InterPro IPR006073 GTP_binding_domain # InterPro IPR015946 KH_dom-like_a/b # InterPro IPR016484 GTP-bd_EngA # InterPro IPR027417 P-loop_NTPase # InterPro IPR031166 G_ENGA # InterPro IPR032859 KH_dom-like # KEGG_Brite ko03009 Ribosome biogenesis # Organism DER_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11649:SF5 PTHR11649:SF5 # PATRIC 32120415 VBIEscCol129921_2610 # PDB 3J8G EM; 5.00 A; X=1-490 # PIR F65027 F65027 # PIRSF PIRSF006485 GTP-binding_EngA # PRINTS PR00326 GTP1OBG # PROSITE PS51712 G_ENGA; 2 # Pfam PF01926 MMR_HSR1; 2 # Pfam PF14714 KH_dom-like # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DER_ECOLI GTPase Der # RefSeq NP_417006 NC_000913.3 # RefSeq WP_000249410 NZ_LN832404.1 # SIMILARITY Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. EngA (Der) GTPase family. {ECO 0000305}. # SIMILARITY Contains 1 KH-like domain. {ECO 0000305}. # SIMILARITY Contains 2 EngA-type G (guanine nucleotide-binding) domains. {ECO 0000305}. # SUBUNIT DER_ECOLI Associates with the 50S ribosomal subunit in the presence of GMPPNP, a non-hydrolysable GTP analog, and thus probably also in the presence of GTP, but not in the presence of GDP or in the absence of nucleotide. Interacts with YihI via the last 490 residues. {ECO 0000269|PubMed 16930151, ECO 0000269|PubMed 16963571, ECO 0000269|PubMed 20434458}. # SUPFAM SSF52540 SSF52540; 3 # TIGRFAMs TIGR00231 small_GTP; 2 # TIGRFAMs TIGR03594 GTPase_EngA # eggNOG COG1160 LUCA # eggNOG ENOG4105DKZ Bacteria BLAST swissprot:DER_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DER_ECOLI BioCyc ECOL316407:JW5403-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5403-MONOMER BioCyc EcoCyc:G7319-MONOMER http://biocyc.org/getid?id=EcoCyc:G7319-MONOMER BioCyc MetaCyc:G7319-MONOMER http://biocyc.org/getid?id=MetaCyc:G7319-MONOMER COG COG1160 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1160 DIP DIP-48272N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48272N DOI 10.1016/j.jmb.2010.04.040 http://dx.doi.org/10.1016/j.jmb.2010.04.040 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M104455200 http://dx.doi.org/10.1074/jbc.M104455200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1365-2958.2006.05348.x http://dx.doi.org/10.1111/j.1365-2958.2006.05348.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00045-10 http://dx.doi.org/10.1128/JB.00045-10 DOI 10.1128/JB.00959-06 http://dx.doi.org/10.1128/JB.00959-06 DOI 10.1128/JB.01758-07 http://dx.doi.org/10.1128/JB.01758-07 DOI 10.1128/JB.184.10.2692-2698.2002 http://dx.doi.org/10.1128/JB.184.10.2692-2698.2002 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3959 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3959 EcoGene EG14207 http://www.ecogene.org/geneInfo.php?eg_id=EG14207 EnsemblBacteria AAC75564 http://www.ensemblgenomes.org/id/AAC75564 EnsemblBacteria AAC75564 http://www.ensemblgenomes.org/id/AAC75564 EnsemblBacteria BAA16397 http://www.ensemblgenomes.org/id/BAA16397 EnsemblBacteria BAA16397 http://www.ensemblgenomes.org/id/BAA16397 EnsemblBacteria BAA16397 http://www.ensemblgenomes.org/id/BAA16397 EnsemblBacteria b2511 http://www.ensemblgenomes.org/id/b2511 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_function GO:0032794 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032794 GO_function GO:0043022 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043022 GO_process GO:0000027 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000027 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0022618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022618 Gene3D 3.30.300.20 http://www.cathdb.info/version/latest/superfamily/3.30.300.20 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 946983 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946983 HAMAP MF_00195 http://hamap.expasy.org/unirule/MF_00195 HOGENOM HOG000242862 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000242862&db=HOGENOM6 InParanoid P0A6P5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6P5 IntAct P0A6P5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6P5* InterPro IPR005225 http://www.ebi.ac.uk/interpro/entry/IPR005225 InterPro IPR006073 http://www.ebi.ac.uk/interpro/entry/IPR006073 InterPro IPR015946 http://www.ebi.ac.uk/interpro/entry/IPR015946 InterPro IPR016484 http://www.ebi.ac.uk/interpro/entry/IPR016484 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR031166 http://www.ebi.ac.uk/interpro/entry/IPR031166 InterPro IPR032859 http://www.ebi.ac.uk/interpro/entry/IPR032859 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW5403 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5403 KEGG_Gene eco:b2511 http://www.genome.jp/dbget-bin/www_bget?eco:b2511 KEGG_Orthology KO:K03977 http://www.genome.jp/dbget-bin/www_bget?KO:K03977 OMA DVMGTPI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DVMGTPI PANTHER PTHR11649:SF5 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11649:SF5 PDB 3J8G http://www.ebi.ac.uk/pdbe-srv/view/entry/3J8G PDBsum 3J8G http://www.ebi.ac.uk/pdbsum/3J8G PRINTS PR00326 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00326 PROSITE PS51712 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51712 PSORT swissprot:DER_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DER_ECOLI PSORT-B swissprot:DER_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DER_ECOLI PSORT2 swissprot:DER_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DER_ECOLI Pfam PF01926 http://pfam.xfam.org/family/PF01926 Pfam PF14714 http://pfam.xfam.org/family/PF14714 Phobius swissprot:DER_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DER_ECOLI PhylomeDB P0A6P5 http://phylomedb.org/?seqid=P0A6P5 ProteinModelPortal P0A6P5 http://www.proteinmodelportal.org/query/uniprot/P0A6P5 PubMed 11387344 http://www.ncbi.nlm.nih.gov/pubmed/11387344 PubMed 11976298 http://www.ncbi.nlm.nih.gov/pubmed/11976298 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16930151 http://www.ncbi.nlm.nih.gov/pubmed/16930151 PubMed 16963571 http://www.ncbi.nlm.nih.gov/pubmed/16963571 PubMed 18296517 http://www.ncbi.nlm.nih.gov/pubmed/18296517 PubMed 20172997 http://www.ncbi.nlm.nih.gov/pubmed/20172997 PubMed 20434458 http://www.ncbi.nlm.nih.gov/pubmed/20434458 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417006 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417006 RefSeq WP_000249410 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000249410 SMR P0A6P5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6P5 STRING 511145.b2511 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2511&targetmode=cogs STRING COG1160 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1160&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR00231 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00231 TIGRFAMs TIGR03594 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03594 UniProtKB DER_ECOLI http://www.uniprot.org/uniprot/DER_ECOLI UniProtKB-AC P0A6P5 http://www.uniprot.org/uniprot/P0A6P5 charge swissprot:DER_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DER_ECOLI eggNOG COG1160 http://eggnogapi.embl.de/nog_data/html/tree/COG1160 eggNOG ENOG4105DKZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DKZ epestfind swissprot:DER_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DER_ECOLI garnier swissprot:DER_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DER_ECOLI helixturnhelix swissprot:DER_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DER_ECOLI hmoment swissprot:DER_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DER_ECOLI iep swissprot:DER_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DER_ECOLI inforesidue swissprot:DER_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DER_ECOLI octanol swissprot:DER_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DER_ECOLI pepcoil swissprot:DER_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DER_ECOLI pepdigest swissprot:DER_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DER_ECOLI pepinfo swissprot:DER_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DER_ECOLI pepnet swissprot:DER_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DER_ECOLI pepstats swissprot:DER_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DER_ECOLI pepwheel swissprot:DER_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DER_ECOLI pepwindow swissprot:DER_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DER_ECOLI sigcleave swissprot:DER_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DER_ECOLI ## Database ID URL or Descriptions # BioGrid 4260027 13 # EcoGene EG12965 pqiA # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # INDUCTION PQIA_ECOLI By paraquat. # IntAct P0AFL9 2 # InterPro IPR005219 CHP00155 # InterPro IPR007498 PqiA # Organism PQIA_ECOLI Escherichia coli (strain K12) # PATRIC 32117119 VBIEscCol129921_0984 # PIR E64835 E64835 # Pfam PF04403 PqiA; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PQIA_ECOLI Paraquat-inducible protein A # RefSeq NP_415470 NC_000913.3 # RefSeq WP_000333176 NZ_LN832404.1 # SIMILARITY Belongs to the PqiA family. {ECO 0000305}. # SUBCELLULAR LOCATION PQIA_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # TIGRFAMs TIGR00155 pqiA_fam # eggNOG COG2995 LUCA # eggNOG ENOG4105F1S Bacteria BLAST swissprot:PQIA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PQIA_ECOLI BioCyc ECOL316407:JW0933-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0933-MONOMER BioCyc EcoCyc:G6490-MONOMER http://biocyc.org/getid?id=EcoCyc:G6490-MONOMER COG COG2995 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2995 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X81561 http://www.ebi.ac.uk/ena/data/view/X81561 EchoBASE EB2794 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2794 EcoGene EG12965 http://www.ecogene.org/geneInfo.php?eg_id=EG12965 EnsemblBacteria AAC74036 http://www.ensemblgenomes.org/id/AAC74036 EnsemblBacteria AAC74036 http://www.ensemblgenomes.org/id/AAC74036 EnsemblBacteria BAA35708 http://www.ensemblgenomes.org/id/BAA35708 EnsemblBacteria BAA35708 http://www.ensemblgenomes.org/id/BAA35708 EnsemblBacteria BAA35708 http://www.ensemblgenomes.org/id/BAA35708 EnsemblBacteria b0950 http://www.ensemblgenomes.org/id/b0950 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 944999 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944999 HOGENOM HOG000283618 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000283618&db=HOGENOM6 InParanoid P0AFL9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFL9 IntAct P0AFL9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFL9* InterPro IPR005219 http://www.ebi.ac.uk/interpro/entry/IPR005219 InterPro IPR007498 http://www.ebi.ac.uk/interpro/entry/IPR007498 KEGG_Gene ecj:JW0933 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0933 KEGG_Gene eco:b0950 http://www.genome.jp/dbget-bin/www_bget?eco:b0950 KEGG_Orthology KO:K03808 http://www.genome.jp/dbget-bin/www_bget?KO:K03808 OMA GNCRDEA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GNCRDEA PSORT swissprot:PQIA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PQIA_ECOLI PSORT-B swissprot:PQIA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PQIA_ECOLI PSORT2 swissprot:PQIA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PQIA_ECOLI Pfam PF04403 http://pfam.xfam.org/family/PF04403 Phobius swissprot:PQIA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PQIA_ECOLI PhylomeDB P0AFL9 http://phylomedb.org/?seqid=P0AFL9 ProteinModelPortal P0AFL9 http://www.proteinmodelportal.org/query/uniprot/P0AFL9 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7751275 http://www.ncbi.nlm.nih.gov/pubmed/7751275 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415470 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415470 RefSeq WP_000333176 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000333176 STRING 511145.b0950 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0950&targetmode=cogs STRING COG2995 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2995&targetmode=cogs TIGRFAMs TIGR00155 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00155 UniProtKB PQIA_ECOLI http://www.uniprot.org/uniprot/PQIA_ECOLI UniProtKB-AC P0AFL9 http://www.uniprot.org/uniprot/P0AFL9 charge swissprot:PQIA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PQIA_ECOLI eggNOG COG2995 http://eggnogapi.embl.de/nog_data/html/tree/COG2995 eggNOG ENOG4105F1S http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F1S epestfind swissprot:PQIA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PQIA_ECOLI garnier swissprot:PQIA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PQIA_ECOLI helixturnhelix swissprot:PQIA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PQIA_ECOLI hmoment swissprot:PQIA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PQIA_ECOLI iep swissprot:PQIA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PQIA_ECOLI inforesidue swissprot:PQIA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PQIA_ECOLI octanol swissprot:PQIA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PQIA_ECOLI pepcoil swissprot:PQIA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PQIA_ECOLI pepdigest swissprot:PQIA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PQIA_ECOLI pepinfo swissprot:PQIA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PQIA_ECOLI pepnet swissprot:PQIA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PQIA_ECOLI pepstats swissprot:PQIA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PQIA_ECOLI pepwheel swissprot:PQIA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PQIA_ECOLI pepwindow swissprot:PQIA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PQIA_ECOLI sigcleave swissprot:PQIA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PQIA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262819 252 # CATALYTIC ACTIVITY 5,10-methenyltetrahydrofolate + H(2)O = 10- formyltetrahydrofolate. {ECO:0000255|HAMAP-Rule MF_01576}. # CATALYTIC ACTIVITY 5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH. {ECO:0000255|HAMAP- Rule MF_01576}. # EcoGene EG10328 folD # FUNCTION FOLD_ECOLI Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate. This enzyme is specific for NADP. {ECO 0000255|HAMAP-Rule MF_01576, ECO 0000269|PubMed 1748668}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004477 methenyltetrahydrofolate cyclohydrolase activity; IDA:EcoCyc. # GO_function GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity; IBA:GO_Central. # GO_process GO:0000105 histidine biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0006164 purine nucleotide biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0006730 one-carbon metabolic process; IBA:GO_Central. # GO_process GO:0009086 methionine biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0009396 folic acid-containing compound biosynthetic process; IEA:InterPro. # GO_process GO:0035999 tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.720 -; 1. # HAMAP MF_01576 THF_DHG_CYH # IntAct P24186 4 # InterPro IPR000672 THF_DH/CycHdrlase # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR020630 THF_DH/CycHdrlase_cat_dom # InterPro IPR020631 THF_DH/CycHdrlase_NAD-bd_dom # InterPro IPR020867 THF_DH/CycHdrlase_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00670 One carbon pool by folate # KEGG_Pathway ko00720 Carbon fixation pathways in prokaryotes # Organism FOLD_ECOLI Escherichia coli (strain K12) # PATHWAY One-carbon metabolism; tetrahydrofolate interconversion. {ECO:0000255|HAMAP-Rule MF_01576}. # PATRIC 32116218 VBIEscCol129921_0550 # PDB 1B0A X-ray; 2.56 A; A=1-288 # PIR H64784 JS0662 # PRINTS PR00085 THFDHDRGNASE # PROSITE PS00766 THF_DHG_CYH_1 # PROSITE PS00767 THF_DHG_CYH_2 # Pfam PF00763 THF_DHG_CYH # Pfam PF02882 THF_DHG_CYH_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Bifunctional protein FolD {ECO:0000255|HAMAP-Rule MF_01576} # RecName Bifunctional protein FolD {ECO:0000255|HAMAP-Rule MF_01576} # RecName Methenyltetrahydrofolate cyclohydrolase {ECO:0000255|HAMAP-Rule MF_01576} # RecName Methylenetetrahydrofolate dehydrogenase {ECO:0000255|HAMAP-Rule MF_01576} # RefSeq NP_415062 NC_000913.3 # RefSeq WP_000729160 NZ_LN832404.1 # SIMILARITY Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. {ECO:0000255|HAMAP- Rule MF_01576}. # SUBUNIT FOLD_ECOLI Homodimer. {ECO 0000255|HAMAP-Rule MF_01576, ECO 0000269|PubMed 10386884, ECO 0000269|PubMed 1748668}. # SUPFAM SSF51735 SSF51735 # eggNOG COG0190 LUCA # eggNOG ENOG4105CN0 Bacteria BLAST swissprot:FOLD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FOLD_ECOLI BioCyc ECOL316407:JW0518-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0518-MONOMER BioCyc EcoCyc:FOLD-MONOMER http://biocyc.org/getid?id=EcoCyc:FOLD-MONOMER BioCyc MetaCyc:FOLD-MONOMER http://biocyc.org/getid?id=MetaCyc:FOLD-MONOMER COG COG0190 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0190 DIP DIP-9675N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9675N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1110/ps.8.6.1342 http://dx.doi.org/10.1110/ps.8.6.1342 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.5.1.5 {ECO:0000255|HAMAP-Rule:MF_01576} http://www.genome.jp/dbget-bin/www_bget?EC:1.5.1.5 {ECO:0000255|HAMAP-Rule:MF_01576} EC_number EC:3.5.4.9 {ECO:0000255|HAMAP-Rule:MF_01576} http://www.genome.jp/dbget-bin/www_bget?EC:3.5.4.9 {ECO:0000255|HAMAP-Rule:MF_01576} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D10588 http://www.ebi.ac.uk/ena/data/view/D10588 EMBL M74789 http://www.ebi.ac.uk/ena/data/view/M74789 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 ENZYME 1.5.1.5 {ECO:0000255|HAMAP-Rule:MF_01576} http://enzyme.expasy.org/EC/1.5.1.5 {ECO:0000255|HAMAP-Rule:MF_01576} ENZYME 3.5.4.9 {ECO:0000255|HAMAP-Rule:MF_01576} http://enzyme.expasy.org/EC/3.5.4.9 {ECO:0000255|HAMAP-Rule:MF_01576} EchoBASE EB0324 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0324 EcoGene EG10328 http://www.ecogene.org/geneInfo.php?eg_id=EG10328 EnsemblBacteria AAC73631 http://www.ensemblgenomes.org/id/AAC73631 EnsemblBacteria AAC73631 http://www.ensemblgenomes.org/id/AAC73631 EnsemblBacteria BAE76306 http://www.ensemblgenomes.org/id/BAE76306 EnsemblBacteria BAE76306 http://www.ensemblgenomes.org/id/BAE76306 EnsemblBacteria BAE76306 http://www.ensemblgenomes.org/id/BAE76306 EnsemblBacteria b0529 http://www.ensemblgenomes.org/id/b0529 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004477 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004477 GO_function GO:0004488 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004488 GO_process GO:0000105 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000105 GO_process GO:0006164 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006164 GO_process GO:0006730 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006730 GO_process GO:0009086 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009086 GO_process GO:0009396 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009396 GO_process GO:0035999 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035999 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 945221 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945221 HAMAP MF_01576 http://hamap.expasy.org/unirule/MF_01576 HOGENOM HOG000218242 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218242&db=HOGENOM6 InParanoid P24186 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P24186 IntAct P24186 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P24186* IntEnz 1.5.1.5 {ECO:0000255|HAMAP-Rule:MF_01576} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.5.1.5 {ECO:0000255|HAMAP-Rule:MF_01576} IntEnz 3.5.4.9 {ECO:0000255|HAMAP-Rule:MF_01576} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.4.9 {ECO:0000255|HAMAP-Rule:MF_01576} InterPro IPR000672 http://www.ebi.ac.uk/interpro/entry/IPR000672 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR020630 http://www.ebi.ac.uk/interpro/entry/IPR020630 InterPro IPR020631 http://www.ebi.ac.uk/interpro/entry/IPR020631 InterPro IPR020867 http://www.ebi.ac.uk/interpro/entry/IPR020867 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0518 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0518 KEGG_Gene eco:b0529 http://www.genome.jp/dbget-bin/www_bget?eco:b0529 KEGG_Orthology KO:K01491 http://www.genome.jp/dbget-bin/www_bget?KO:K01491 KEGG_Pathway ko00670 http://www.genome.jp/kegg-bin/show_pathway?ko00670 KEGG_Pathway ko00720 http://www.genome.jp/kegg-bin/show_pathway?ko00720 KEGG_Reaction rn:R01220 http://www.genome.jp/dbget-bin/www_bget?rn:R01220 KEGG_Reaction rn:R01655 http://www.genome.jp/dbget-bin/www_bget?rn:R01655 OMA GQPMALM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GQPMALM PDB 1B0A http://www.ebi.ac.uk/pdbe-srv/view/entry/1B0A PDBsum 1B0A http://www.ebi.ac.uk/pdbsum/1B0A PRINTS PR00085 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00085 PROSITE PS00766 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00766 PROSITE PS00767 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00767 PSORT swissprot:FOLD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FOLD_ECOLI PSORT-B swissprot:FOLD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FOLD_ECOLI PSORT2 swissprot:FOLD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FOLD_ECOLI Pfam PF00763 http://pfam.xfam.org/family/PF00763 Pfam PF02882 http://pfam.xfam.org/family/PF02882 Phobius swissprot:FOLD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FOLD_ECOLI PhylomeDB P24186 http://phylomedb.org/?seqid=P24186 ProteinModelPortal P24186 http://www.proteinmodelportal.org/query/uniprot/P24186 PubMed 10386884 http://www.ncbi.nlm.nih.gov/pubmed/10386884 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1748668 http://www.ncbi.nlm.nih.gov/pubmed/1748668 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415062 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415062 RefSeq WP_000729160 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000729160 SMR P24186 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P24186 STRING 511145.b0529 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0529&targetmode=cogs STRING COG0190 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0190&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB FOLD_ECOLI http://www.uniprot.org/uniprot/FOLD_ECOLI UniProtKB-AC P24186 http://www.uniprot.org/uniprot/P24186 charge swissprot:FOLD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FOLD_ECOLI eggNOG COG0190 http://eggnogapi.embl.de/nog_data/html/tree/COG0190 eggNOG ENOG4105CN0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CN0 epestfind swissprot:FOLD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FOLD_ECOLI garnier swissprot:FOLD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FOLD_ECOLI helixturnhelix swissprot:FOLD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FOLD_ECOLI hmoment swissprot:FOLD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FOLD_ECOLI iep swissprot:FOLD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FOLD_ECOLI inforesidue swissprot:FOLD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FOLD_ECOLI octanol swissprot:FOLD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FOLD_ECOLI pepcoil swissprot:FOLD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FOLD_ECOLI pepdigest swissprot:FOLD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FOLD_ECOLI pepinfo swissprot:FOLD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FOLD_ECOLI pepnet swissprot:FOLD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FOLD_ECOLI pepstats swissprot:FOLD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FOLD_ECOLI pepwheel swissprot:FOLD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FOLD_ECOLI pepwindow swissprot:FOLD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FOLD_ECOLI sigcleave swissprot:FOLD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FOLD_ECOLI ## Database ID URL or Descriptions # BRENDA 3.1.2 2026 # BioGrid 4261839 24 # CAUTION YBHC_ECOLI Lacks the conserved Asp residue in position 252 essential for pectinase activity. Likewise, most of the residues involved in substrate binding are not conserved. Was originally (PubMed 15808744) thought to have palmitoyl-CoA thioesterase activity, but PubMed 19452549 were unable to detect any pectinase or palmitoyl-CoA thioesterase activity. Its enzyme activity is therefore unsure. {ECO 0000305|PubMed 15808744}. # EcoGene EG12875 ybhC # FUNCTION YBHC_ECOLI Putative thioesterase. Does not bind pectin, and has no pectinesterase activity. {ECO 0000269|PubMed 15808744, ECO 0000269|PubMed 19452549}. # GO_component GO:0005618 cell wall; IEA:InterPro. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_function GO:0030599 pectinesterase activity; IEA:InterPro. # GO_function GO:0045330 aspartyl esterase activity; IEA:UniProtKB-KW. # GO_process GO:0042545 cell wall modification; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005618 cell wall # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 2.160.20.10 -; 1. # IntAct P46130 3 # InterPro IPR000070 Pectinesterase_cat # InterPro IPR011050 Pectin_lyase_fold/virulence # InterPro IPR012334 Pectin_lyas_fold # InterPro IPR033131 Pectinesterase_Asp_AS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00040 Pentose and glucuronate interconversions # KEGG_Pathway ko00500 Starch and sucrose metabolism # Organism YBHC_ECOLI Escherichia coli (strain K12) # PATRIC 32116745 VBIEscCol129921_0798 # PDB 3GRH X-ray; 1.70 A; A=29-427 # PIR D64813 D64813 # PROSITE PS00503 PECTINESTERASE_2 # PROSITE PS00800 PECTINESTERASE_1 # Pfam PF01095 Pectinesterase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBHC_ECOLI Putative acyl-CoA thioester hydrolase YbhC # RefSeq NP_415293 NC_000913.3 # RefSeq WP_001091569 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=U39938; Type=Frameshift; Positions=37; Evidence={ECO 0000305}; # SIMILARITY Belongs to the pectinesterase family. {ECO 0000305}. # SUBCELLULAR LOCATION YBHC_ECOLI Cell outer membrane {ECO 0000305}; Lipid- anchor {ECO 0000305}. # SUPFAM SSF51126 SSF51126; 3 # eggNOG COG4677 LUCA # eggNOG ENOG4105NBR Bacteria BLAST swissprot:YBHC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBHC_ECOLI BioCyc ECOL316407:JW0755-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0755-MONOMER BioCyc EcoCyc:EG12875-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12875-MONOMER DIP DIP-11407N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11407N DOI 10.1002/prot.22453 http://dx.doi.org/10.1002/prot.22453 DOI 10.1016/j.fmrre.2004.12.006 http://dx.doi.org/10.1016/j.fmrre.2004.12.006 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1432-1327.2000.01296.x http://dx.doi.org/10.1046/j.1432-1327.2000.01296.x DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1126/science.331474 http://dx.doi.org/10.1126/science.331474 EC_number EC:3.1.2.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.2.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01638 http://www.ebi.ac.uk/ena/data/view/J01638 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U39938 http://www.ebi.ac.uk/ena/data/view/U39938 ENZYME 3.1.2.- http://enzyme.expasy.org/EC/3.1.2.- EchoBASE EB2713 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2713 EcoGene EG12875 http://www.ecogene.org/geneInfo.php?eg_id=EG12875 EnsemblBacteria AAC73859 http://www.ensemblgenomes.org/id/AAC73859 EnsemblBacteria AAC73859 http://www.ensemblgenomes.org/id/AAC73859 EnsemblBacteria BAA35436 http://www.ensemblgenomes.org/id/BAA35436 EnsemblBacteria BAA35436 http://www.ensemblgenomes.org/id/BAA35436 EnsemblBacteria BAA35436 http://www.ensemblgenomes.org/id/BAA35436 EnsemblBacteria b0772 http://www.ensemblgenomes.org/id/b0772 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005618 GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_function GO:0030599 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030599 GO_function GO:0045330 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045330 GO_process GO:0042545 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042545 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005618 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 2.160.20.10 http://www.cathdb.info/version/latest/superfamily/2.160.20.10 GeneID 945381 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945381 HOGENOM HOG000118057 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118057&db=HOGENOM6 InParanoid P46130 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P46130 IntAct P46130 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P46130* IntEnz 3.1.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.2 InterPro IPR000070 http://www.ebi.ac.uk/interpro/entry/IPR000070 InterPro IPR011050 http://www.ebi.ac.uk/interpro/entry/IPR011050 InterPro IPR012334 http://www.ebi.ac.uk/interpro/entry/IPR012334 InterPro IPR033131 http://www.ebi.ac.uk/interpro/entry/IPR033131 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0755 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0755 KEGG_Gene eco:b0772 http://www.genome.jp/dbget-bin/www_bget?eco:b0772 KEGG_Orthology KO:K01051 http://www.genome.jp/dbget-bin/www_bget?KO:K01051 KEGG_Pathway ko00040 http://www.genome.jp/kegg-bin/show_pathway?ko00040 KEGG_Pathway ko00500 http://www.genome.jp/kegg-bin/show_pathway?ko00500 KEGG_Reaction rn:R02362 http://www.genome.jp/dbget-bin/www_bget?rn:R02362 MINT MINT-1240146 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1240146 OMA FNRMWEY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FNRMWEY PDB 3GRH http://www.ebi.ac.uk/pdbe-srv/view/entry/3GRH PDBsum 3GRH http://www.ebi.ac.uk/pdbsum/3GRH PROSITE PS00503 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00503 PROSITE PS00800 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00800 PSORT swissprot:YBHC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBHC_ECOLI PSORT-B swissprot:YBHC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBHC_ECOLI PSORT2 swissprot:YBHC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBHC_ECOLI Pfam PF01095 http://pfam.xfam.org/family/PF01095 Phobius swissprot:YBHC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBHC_ECOLI PhylomeDB P46130 http://phylomedb.org/?seqid=P46130 ProteinModelPortal P46130 http://www.proteinmodelportal.org/query/uniprot/P46130 PubMed 10806384 http://www.ncbi.nlm.nih.gov/pubmed/10806384 PubMed 15808744 http://www.ncbi.nlm.nih.gov/pubmed/15808744 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19452549 http://www.ncbi.nlm.nih.gov/pubmed/19452549 PubMed 331474 http://www.ncbi.nlm.nih.gov/pubmed/331474 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415293 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415293 RefSeq WP_001091569 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001091569 SMR P46130 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P46130 STRING 511145.b0772 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0772&targetmode=cogs SUPFAM SSF51126 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51126 UniProtKB YBHC_ECOLI http://www.uniprot.org/uniprot/YBHC_ECOLI UniProtKB-AC P46130 http://www.uniprot.org/uniprot/P46130 charge swissprot:YBHC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBHC_ECOLI eggNOG COG4677 http://eggnogapi.embl.de/nog_data/html/tree/COG4677 eggNOG ENOG4105NBR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105NBR epestfind swissprot:YBHC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBHC_ECOLI garnier swissprot:YBHC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBHC_ECOLI helixturnhelix swissprot:YBHC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBHC_ECOLI hmoment swissprot:YBHC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBHC_ECOLI iep swissprot:YBHC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBHC_ECOLI inforesidue swissprot:YBHC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBHC_ECOLI octanol swissprot:YBHC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBHC_ECOLI pepcoil swissprot:YBHC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBHC_ECOLI pepdigest swissprot:YBHC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBHC_ECOLI pepinfo swissprot:YBHC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBHC_ECOLI pepnet swissprot:YBHC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBHC_ECOLI pepstats swissprot:YBHC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBHC_ECOLI pepwheel swissprot:YBHC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBHC_ECOLI pepwindow swissprot:YBHC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBHC_ECOLI sigcleave swissprot:YBHC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBHC_ECOLI ## Database ID URL or Descriptions # AltName FTSH_ECOLI Cell division protease FtsH # BRENDA 3.4.24.B17 2026 # BRENDA 3.4.24.B20 2026 # BioGrid 4262980 336 # CAUTION Glu-476 was identified as the third Zn ligand (PubMed:11827531), however in other crystal structures (Aquifex aeolicus and Thermotoga maritima) the conserved equivalent residue does not bind Zn. Instead it makes a hydrogen bond with the side chain of the first catalytic Zn-binding residue and indirectly stabilizes the Zn. {ECO 0000305|PubMed:11827531}. # COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI 29105; Note=Binds 1 zinc ion per subunit.; # DISRUPTION PHENOTYPE Lethality, due to increased levels of LpxC, which increases the level of LPS in the cell and results in formation of abnormal membrane structures in the periplasm. Lethality is suppressed under conditions in which LPS synthesis is reduced. {ECO:0000269|PubMed 10048027}. # ENZYME REGULATION (Microbial infection) Activity against phage lambda cII protein is inhibited by EDTA but not by PMSF. In vitro pre-incubation of FtsH with HflKC abolishes its activity against phage lambda cII protein at the cytoplasmic side of the membrane. {ECO:0000269|PubMed 9159109}. # EcoGene EG11506 ftsH # FUNCTION FTSH_ECOLI Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins. Degrades a few membrane proteins that have not been assembled into complexes such as SecY, F(0) ATPase subunit a and YccA, and also cytoplasmic proteins sigma-32, LpxC, KdtA and phage lambda cII protein among others. Degrades membrane proteins in a processive manner starting at either the N- or C-terminus; recognition requires a cytoplasmic tail of about 20 residues with no apparent sequence requirements. It presumably dislocates membrane-spanning and periplasmic segments of the protein into the cytoplasm to degrade them, this probably requires ATP. Degrades C-terminal- tagged cytoplasmic proteins which are tagged with an 11-amino-acid nonpolar destabilizing tail via a mechanism involving the 10SA (SsrA) stable RNA. # FUNCTION FTSH_ECOLI As FtsH regulates the levels of both LpxC and KdtA it is required for synthesis of both the protein and lipid components of lipopolysaccharide (LPS). # GO_component GO:0005886 plasma membrane; IBA:GO_Central. # GO_component GO:0016021 integral component of membrane; IDA:EcoliWiki. # GO_function GO:0004176 ATP-dependent peptidase activity; IBA:GO_Central. # GO_function GO:0004222 metalloendopeptidase activity; IEA:InterPro. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008237 metallopeptidase activity; IBA:GO_Central. # GO_function GO:0008270 zinc ion binding; IDA:EcoliWiki. # GO_function GO:0016887 ATPase activity; IDA:EcoliWiki. # GO_function GO:0030145 manganese ion binding; IDA:EcoliWiki. # GO_function GO:0043273 CTPase activity; IDA:EcoliWiki. # GO_process GO:0006508 proteolysis; IDA:EcoliWiki. # GO_process GO:0030163 protein catabolic process; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # Gene3D 3.40.50.300 -; 1. # HAMAP MF_01458 FtsH # IntAct P0AAI3 28 # InterPro IPR000642 Peptidase_M41 # InterPro IPR003593 AAA+_ATPase # InterPro IPR003959 ATPase_AAA_core # InterPro IPR003960 ATPase_AAA_CS # InterPro IPR005936 FtsH # InterPro IPR011546 Pept_M41_FtsH_extracell # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # KEGG_Brite ko03110 Chaperones and folding catalysts # MISCELLANEOUS FTSH_ECOLI Requires ATP for protease catalytic activity, probably due to tight coupling of the 2 activities; ADP or non- hydrolyzable analogs cannot substitute, except when unfolded, non- physiological substrates are tested. # MISCELLANEOUS The ftsH gene was discovered independently through 3 different phenotypes and received 3 different names: ftsH, for filamentous temperature-sensitive; tolZ, for colicin tolerance, and hlfB, because mutants show a high frequency of lysogenization when infected with phage lambda. {ECO 0000305|PubMed:19744556}. # Organism FTSH_ECOLI Escherichia coli (strain K12) # PATRIC 32121774 VBIEscCol129921_3271 # PDB 1LV7 X-ray; 1.50 A; A=141-395 # PDB 4V0B X-ray; 2.55 A; A/B/C=25-96 # PIR S35109 S35109 # PROSITE PS00674 AAA # Pfam PF00004 AAA # Pfam PF01434 Peptidase_M41 # Pfam PF06480 FtsH_ext # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ATP-dependent zinc metalloprotease FtsH {ECO:0000255|HAMAP-Rule MF_01458} # RefSeq NP_417645 NC_000913.3 # RefSeq WP_001107467 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97508.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY In the C-terminal section; belongs to the peptidase M41 family. {ECO:0000255|HAMAP-Rule MF_01458}. # SIMILARITY In the central section; belongs to the AAA ATPase family. {ECO:0000255|HAMAP-Rule MF_01458}. # SMART SM00382 AAA # SUBCELLULAR LOCATION FTSH_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01458, ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 8444797, ECO 0000269|PubMed 8947034}; Multi- pass membrane protein {ECO 0000255|HAMAP-Rule MF_01458, ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 8444797, ECO 0000269|PubMed 8947034}. # SUBUNIT FTSH_ECOLI The E.coli AAA domain has been modeled as a homohexamer, in Thermus thermophilus the same domain crystallizes as a homohexamer. Forms a complex with HflKC (formerly called HflA); complex formation is stimulated by ATP. Interacts with YccA, and probably weakly with QmcA. Can be cross-linked to YidC (OxaA) and to a nascent polypeptide chain for an integral membrane protein. {ECO 0000269|PubMed 18387365, ECO 0000269|PubMed 8947034, ECO 0000269|PubMed 9159109, ECO 0000269|PubMed 9636708}. # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR01241 FtsH_fam # eggNOG COG0465 LUCA # eggNOG ENOG4105C3H Bacteria BLAST swissprot:FTSH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FTSH_ECOLI BioCyc ECOL316407:JW3145-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3145-MONOMER BioCyc EcoCyc:EG11506-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11506-MONOMER BioCyc MetaCyc:EG11506-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11506-MONOMER COG COG0465 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0465 DIP DIP-35828N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35828N DOI 10.1006/jmbi.1998.1781 http://dx.doi.org/10.1006/jmbi.1998.1781 DOI 10.1016/0923-2508(91)90041-8 http://dx.doi.org/10.1016/0923-2508(91)90041-8 DOI 10.1016/S0969-2126(02)00806-7 http://dx.doi.org/10.1016/S0969-2126(02)00806-7 DOI 10.1016/j.febslet.2008.02.082 http://dx.doi.org/10.1016/j.febslet.2008.02.082 DOI 10.1016/j.resmic.2009.08.011 http://dx.doi.org/10.1016/j.resmic.2009.08.011 DOI 10.1021/bi015748o http://dx.doi.org/10.1021/bi015748o DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1999.01221.x http://dx.doi.org/10.1046/j.1365-2958.1999.01221.x DOI 10.1073/pnas.90.22.10861 http://dx.doi.org/10.1073/pnas.90.22.10861 DOI 10.1073/pnas.92.10.4532 http://dx.doi.org/10.1073/pnas.92.10.4532 DOI 10.1073/pnas.94.11.5544 http://dx.doi.org/10.1073/pnas.94.11.5544 DOI 10.1074/jbc.274.37.26225 http://dx.doi.org/10.1074/jbc.274.37.26225 DOI 10.1074/jbc.M308327200 http://dx.doi.org/10.1074/jbc.M308327200 DOI 10.1093/embo-reports/kvd005 http://dx.doi.org/10.1093/embo-reports/kvd005 DOI 10.1093/emboj/18.11.2970 http://dx.doi.org/10.1093/emboj/18.11.2970 DOI 10.1093/jb/mvp071 http://dx.doi.org/10.1093/jb/mvp071 DOI 10.1101/gad.12.9.1348 http://dx.doi.org/10.1101/gad.12.9.1348 DOI 10.1107/S0907444902006972 http://dx.doi.org/10.1107/S0907444902006972 DOI 10.1111/j.1365-2958.2006.05104.x http://dx.doi.org/10.1111/j.1365-2958.2006.05104.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00871-08 http://dx.doi.org/10.1128/JB.00871-08 DOI 10.1128/JB.184.17.4775-4782.2002 http://dx.doi.org/10.1128/JB.184.17.4775-4782.2002 EC_number EC:3.4.24.- {ECO:0000255|HAMAP-Rule:MF_01458} http://www.genome.jp/dbget-bin/www_bget?EC:3.4.24.- {ECO:0000255|HAMAP-Rule:MF_01458} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M83138 http://www.ebi.ac.uk/ena/data/view/M83138 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U01376 http://www.ebi.ac.uk/ena/data/view/U01376 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 3.4.24.- {ECO:0000255|HAMAP-Rule:MF_01458} http://enzyme.expasy.org/EC/3.4.24.- {ECO:0000255|HAMAP-Rule:MF_01458} EchoBASE EB1469 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1469 EcoGene EG11506 http://www.ecogene.org/geneInfo.php?eg_id=EG11506 EnsemblBacteria AAC76210 http://www.ensemblgenomes.org/id/AAC76210 EnsemblBacteria AAC76210 http://www.ensemblgenomes.org/id/AAC76210 EnsemblBacteria BAE77222 http://www.ensemblgenomes.org/id/BAE77222 EnsemblBacteria BAE77222 http://www.ensemblgenomes.org/id/BAE77222 EnsemblBacteria BAE77222 http://www.ensemblgenomes.org/id/BAE77222 EnsemblBacteria b3178 http://www.ensemblgenomes.org/id/b3178 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0004176 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004176 GO_function GO:0004222 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004222 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008237 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008237 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_function GO:0043273 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043273 GO_process GO:0006508 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006508 GO_process GO:0030163 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030163 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947690 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947690 HAMAP MF_01458 http://hamap.expasy.org/unirule/MF_01458 HOGENOM HOG000217276 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000217276&db=HOGENOM6 InParanoid P0AAI3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAI3 IntAct P0AAI3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAI3* IntEnz 3.4.24.- {ECO:0000255|HAMAP-Rule:MF_01458} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.24.- {ECO:0000255|HAMAP-Rule:MF_01458} InterPro IPR000642 http://www.ebi.ac.uk/interpro/entry/IPR000642 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR003959 http://www.ebi.ac.uk/interpro/entry/IPR003959 InterPro IPR003960 http://www.ebi.ac.uk/interpro/entry/IPR003960 InterPro IPR005936 http://www.ebi.ac.uk/interpro/entry/IPR005936 InterPro IPR011546 http://www.ebi.ac.uk/interpro/entry/IPR011546 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW3145 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3145 KEGG_Gene eco:b3178 http://www.genome.jp/dbget-bin/www_bget?eco:b3178 KEGG_Orthology KO:K03798 http://www.genome.jp/dbget-bin/www_bget?KO:K03798 MINT MINT-1226643 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1226643 OMA NMDILHS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NMDILHS PDB 1LV7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1LV7 PDB 4V0B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V0B PDBsum 1LV7 http://www.ebi.ac.uk/pdbsum/1LV7 PDBsum 4V0B http://www.ebi.ac.uk/pdbsum/4V0B PROSITE PS00674 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00674 PSORT swissprot:FTSH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FTSH_ECOLI PSORT-B swissprot:FTSH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FTSH_ECOLI PSORT2 swissprot:FTSH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FTSH_ECOLI Pfam PF00004 http://pfam.xfam.org/family/PF00004 Pfam PF01434 http://pfam.xfam.org/family/PF01434 Pfam PF06480 http://pfam.xfam.org/family/PF06480 Phobius swissprot:FTSH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FTSH_ECOLI PhylomeDB P0AAI3 http://phylomedb.org/?seqid=P0AAI3 ProteinModelPortal P0AAI3 http://www.proteinmodelportal.org/query/uniprot/P0AAI3 PubMed 10048027 http://www.ncbi.nlm.nih.gov/pubmed/10048027 PubMed 10357810 http://www.ncbi.nlm.nih.gov/pubmed/10357810 PubMed 10473576 http://www.ncbi.nlm.nih.gov/pubmed/10473576 PubMed 11256624 http://www.ncbi.nlm.nih.gov/pubmed/11256624 PubMed 11827531 http://www.ncbi.nlm.nih.gov/pubmed/11827531 PubMed 12037319 http://www.ncbi.nlm.nih.gov/pubmed/12037319 PubMed 12169602 http://www.ncbi.nlm.nih.gov/pubmed/12169602 PubMed 12176385 http://www.ncbi.nlm.nih.gov/pubmed/12176385 PubMed 14514680 http://www.ncbi.nlm.nih.gov/pubmed/14514680 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16573693 http://www.ncbi.nlm.nih.gov/pubmed/16573693 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18387365 http://www.ncbi.nlm.nih.gov/pubmed/18387365 PubMed 18776015 http://www.ncbi.nlm.nih.gov/pubmed/18776015 PubMed 1925026 http://www.ncbi.nlm.nih.gov/pubmed/1925026 PubMed 19454621 http://www.ncbi.nlm.nih.gov/pubmed/19454621 PubMed 19744556 http://www.ncbi.nlm.nih.gov/pubmed/19744556 PubMed 7753838 http://www.ncbi.nlm.nih.gov/pubmed/7753838 PubMed 7781608 http://www.ncbi.nlm.nih.gov/pubmed/7781608 PubMed 8106505 http://www.ncbi.nlm.nih.gov/pubmed/8106505 PubMed 8248182 http://www.ncbi.nlm.nih.gov/pubmed/8248182 PubMed 8444796 http://www.ncbi.nlm.nih.gov/pubmed/8444796 PubMed 8444797 http://www.ncbi.nlm.nih.gov/pubmed/8444797 PubMed 8947034 http://www.ncbi.nlm.nih.gov/pubmed/8947034 PubMed 9159109 http://www.ncbi.nlm.nih.gov/pubmed/9159109 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9573051 http://www.ncbi.nlm.nih.gov/pubmed/9573051 PubMed 9636708 http://www.ncbi.nlm.nih.gov/pubmed/9636708 RefSeq NP_417645 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417645 RefSeq WP_001107467 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001107467 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P0AAI3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAI3 STRING 511145.b3178 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3178&targetmode=cogs STRING COG0465 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0465&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR01241 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01241 UniProtKB FTSH_ECOLI http://www.uniprot.org/uniprot/FTSH_ECOLI UniProtKB-AC P0AAI3 http://www.uniprot.org/uniprot/P0AAI3 charge swissprot:FTSH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FTSH_ECOLI eggNOG COG0465 http://eggnogapi.embl.de/nog_data/html/tree/COG0465 eggNOG ENOG4105C3H http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C3H epestfind swissprot:FTSH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FTSH_ECOLI garnier swissprot:FTSH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FTSH_ECOLI helixturnhelix swissprot:FTSH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FTSH_ECOLI hmoment swissprot:FTSH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FTSH_ECOLI iep swissprot:FTSH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FTSH_ECOLI inforesidue swissprot:FTSH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FTSH_ECOLI octanol swissprot:FTSH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FTSH_ECOLI pepcoil swissprot:FTSH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FTSH_ECOLI pepdigest swissprot:FTSH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FTSH_ECOLI pepinfo swissprot:FTSH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FTSH_ECOLI pepnet swissprot:FTSH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FTSH_ECOLI pepstats swissprot:FTSH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FTSH_ECOLI pepwheel swissprot:FTSH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FTSH_ECOLI pepwindow swissprot:FTSH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FTSH_ECOLI sigcleave swissprot:FTSH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FTSH_ECOLI ## Database ID URL or Descriptions # BRENDA 2.7.11 2026 # BioGrid 4261467 10 # CATALYTIC ACTIVITY ATP + [isocitrate dehydrogenase (NADP(+))] = ADP + [isocitrate dehydrogenase (NADP(+))] phosphate. {ECO:0000255|HAMAP-Rule MF_00747}. # EcoGene EG10026 aceK # FUNCTION ACEK_ECOLI Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation. # GO_component GO:0005737 cytoplasm; IC:EcoliWiki. # GO_function GO:0004674 protein serine/threonine kinase activity; IDA:EcoCyc. # GO_function GO:0004722 protein serine/threonine phosphatase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IDA:EcoliWiki. # GO_function GO:0008772 [isocitrate dehydrogenase (NADP+)] kinase activity; IDA:EcoCyc. # GO_function GO:0016208 AMP binding; IDA:EcoCyc. # GO_function GO:0101014 [isocitrate dehydrogenase (NADP+)] phosphatase activity; IEA:UniProtKB-EC. # GO_process GO:0006006 glucose metabolic process; IEA:InterPro. # GO_process GO:0006097 glyoxylate cycle; IC:EcoliWiki. # GO_process GO:0006099 tricarboxylic acid cycle; IC:EcoliWiki. # GO_process GO:0018105 peptidyl-serine phosphorylation; IDA:EcoCyc. # GO_process GO:0050790 regulation of catalytic activity; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0044281 small molecule metabolic process # HAMAP MF_00747 AceK # IntAct P11071 12 # InterPro IPR010452 Isocitrate_DH_AceK # KEGG_Brite ko01000 Enzymes # Organism ACEK_ECOLI Escherichia coli (strain K12) # PATRIC 32123561 VBIEscCol129921_4129 # PIR G65208 KIECID # PIRSF PIRSF000719 AceK # Pfam PF06315 AceK # ProDom PD043552 Isocitrate_DH_AceK # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Isocitrate dehydrogenase kinase/phosphatase {ECO:0000255|HAMAP-Rule MF_00747} # RefSeq NP_418440 NC_000913.3 # RefSeq WP_001137220 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA24007.1; Type=Frameshift; Positions=92, 137, 166; Evidence={ECO 0000305}; # SIMILARITY Belongs to the AceK family. {ECO:0000255|HAMAP- Rule MF_00747}. # SUBCELLULAR LOCATION ACEK_ECOLI Cytoplasm. # eggNOG COG4579 LUCA # eggNOG ENOG4105VS7 Bacteria BLAST swissprot:ACEK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ACEK_ECOLI BioCyc ECOL316407:JW3976-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3976-MONOMER BioCyc EcoCyc:ICITDEHASE-KIN-PHOSPHA http://biocyc.org/getid?id=EcoCyc:ICITDEHASE-KIN-PHOSPHA BioCyc MetaCyc:ICITDEHASE-KIN-PHOSPHA http://biocyc.org/getid?id=MetaCyc:ICITDEHASE-KIN-PHOSPHA COG COG4579 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4579 DIP DIP-9041N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9041N DOI 10.1016/0300-9084(89)90110-7 http://dx.doi.org/10.1016/0300-9084(89)90110-7 DOI 10.1016/0378-1119(91)90024-6 http://dx.doi.org/10.1016/0378-1119(91)90024-6 DOI 10.1021/bi001713x http://dx.doi.org/10.1021/bi001713x DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.11.5 {ECO:0000255|HAMAP-Rule:MF_00747} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.11.5 {ECO:0000255|HAMAP-Rule:MF_00747} EC_number EC:3.1.3.- {ECO:0000255|HAMAP-Rule:MF_00747} http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.- {ECO:0000255|HAMAP-Rule:MF_00747} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M18974 http://www.ebi.ac.uk/ena/data/view/M18974 EMBL M20714 http://www.ebi.ac.uk/ena/data/view/M20714 EMBL M22621 http://www.ebi.ac.uk/ena/data/view/M22621 EMBL M63497 http://www.ebi.ac.uk/ena/data/view/M63497 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.11.5 {ECO:0000255|HAMAP-Rule:MF_00747} http://enzyme.expasy.org/EC/2.7.11.5 {ECO:0000255|HAMAP-Rule:MF_00747} ENZYME 3.1.3.- {ECO:0000255|HAMAP-Rule:MF_00747} http://enzyme.expasy.org/EC/3.1.3.- {ECO:0000255|HAMAP-Rule:MF_00747} EchoBASE EB0025 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0025 EcoGene EG10026 http://www.ecogene.org/geneInfo.php?eg_id=EG10026 EnsemblBacteria AAC76986 http://www.ensemblgenomes.org/id/AAC76986 EnsemblBacteria AAC76986 http://www.ensemblgenomes.org/id/AAC76986 EnsemblBacteria BAE78018 http://www.ensemblgenomes.org/id/BAE78018 EnsemblBacteria BAE78018 http://www.ensemblgenomes.org/id/BAE78018 EnsemblBacteria BAE78018 http://www.ensemblgenomes.org/id/BAE78018 EnsemblBacteria b4016 http://www.ensemblgenomes.org/id/b4016 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004674 GO_function GO:0004722 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004722 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008772 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008772 GO_function GO:0016208 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016208 GO_function GO:0101014 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0101014 GO_process GO:0006006 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006006 GO_process GO:0006097 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006097 GO_process GO:0006099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006099 GO_process GO:0018105 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018105 GO_process GO:0050790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050790 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 944797 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944797 HAMAP MF_00747 http://hamap.expasy.org/unirule/MF_00747 HOGENOM HOG000247673 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000247673&db=HOGENOM6 InParanoid P11071 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P11071 IntAct P11071 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P11071* IntEnz 2.7.11.5 {ECO:0000255|HAMAP-Rule:MF_00747} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.11.5 {ECO:0000255|HAMAP-Rule:MF_00747} IntEnz 3.1.3.- {ECO:0000255|HAMAP-Rule:MF_00747} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.- {ECO:0000255|HAMAP-Rule:MF_00747} InterPro IPR010452 http://www.ebi.ac.uk/interpro/entry/IPR010452 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3976 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3976 KEGG_Gene eco:b4016 http://www.genome.jp/dbget-bin/www_bget?eco:b4016 KEGG_Orthology KO:K00906 http://www.genome.jp/dbget-bin/www_bget?KO:K00906 MINT MINT-1711235 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1711235 OMA EPWYSVG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EPWYSVG PSORT swissprot:ACEK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ACEK_ECOLI PSORT-B swissprot:ACEK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ACEK_ECOLI PSORT2 swissprot:ACEK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ACEK_ECOLI Pfam PF06315 http://pfam.xfam.org/family/PF06315 Phobius swissprot:ACEK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ACEK_ECOLI ProteinModelPortal P11071 http://www.proteinmodelportal.org/query/uniprot/P11071 PubMed 11258918 http://www.ncbi.nlm.nih.gov/pubmed/11258918 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1995429 http://www.ncbi.nlm.nih.gov/pubmed/1995429 PubMed 2557093 http://www.ncbi.nlm.nih.gov/pubmed/2557093 PubMed 2826408 http://www.ncbi.nlm.nih.gov/pubmed/2826408 PubMed 2836370 http://www.ncbi.nlm.nih.gov/pubmed/2836370 PubMed 3049537 http://www.ncbi.nlm.nih.gov/pubmed/3049537 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418440 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418440 RefSeq WP_001137220 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001137220 SMR P11071 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P11071 STRING 511145.b4016 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4016&targetmode=cogs STRING COG4579 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4579&targetmode=cogs UniProtKB ACEK_ECOLI http://www.uniprot.org/uniprot/ACEK_ECOLI UniProtKB-AC P11071 http://www.uniprot.org/uniprot/P11071 charge swissprot:ACEK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ACEK_ECOLI eggNOG COG4579 http://eggnogapi.embl.de/nog_data/html/tree/COG4579 eggNOG ENOG4105VS7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VS7 epestfind swissprot:ACEK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ACEK_ECOLI garnier swissprot:ACEK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ACEK_ECOLI helixturnhelix swissprot:ACEK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ACEK_ECOLI hmoment swissprot:ACEK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ACEK_ECOLI iep swissprot:ACEK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ACEK_ECOLI inforesidue swissprot:ACEK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ACEK_ECOLI octanol swissprot:ACEK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ACEK_ECOLI pepcoil swissprot:ACEK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ACEK_ECOLI pepdigest swissprot:ACEK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ACEK_ECOLI pepinfo swissprot:ACEK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ACEK_ECOLI pepnet swissprot:ACEK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ACEK_ECOLI pepstats swissprot:ACEK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ACEK_ECOLI pepwheel swissprot:ACEK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ACEK_ECOLI pepwindow swissprot:ACEK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ACEK_ECOLI sigcleave swissprot:ACEK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ACEK_ECOLI ## Database ID URL or Descriptions # CAUTION There is no equivalent of this gene in strain K12 / MG1655. {ECO 0000305}. # FUNCTION INH14_ECOLI Involved in the transposition of the insertion sequence IS5. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # InterPro IPR002559 Transposase_11 # InterPro IPR008490 Transposase_InsH_N # Organism INH14_ECOLI Escherichia coli (strain K12) # Pfam PF01609 DDE_Tnp_1 # Pfam PF05598 DUF772 # RecName INH14_ECOLI Transposase InsH for insertion sequence element IS5-14 # RefSeq WP_000019403 NZ_LN832404.1 # SIMILARITY Belongs to the transposase 11 family. {ECO 0000305}. # eggNOG COG3039 LUCA # eggNOG ENOG4105F2I Bacteria BLAST swissprot:INH14_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INH14_ECOLI DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EnsemblBacteria BAA15962 http://www.ensemblgenomes.org/id/BAA15962 EnsemblBacteria BAA15962 http://www.ensemblgenomes.org/id/BAA15962 EnsemblBacteria BAA15962 http://www.ensemblgenomes.org/id/BAA15962 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 InterPro IPR002559 http://www.ebi.ac.uk/interpro/entry/IPR002559 InterPro IPR008490 http://www.ebi.ac.uk/interpro/entry/IPR008490 KEGG_Gene ecj:JW5914 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5914 PSORT swissprot:INH14_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INH14_ECOLI PSORT-B swissprot:INH14_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INH14_ECOLI PSORT2 swissprot:INH14_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INH14_ECOLI Pfam PF01609 http://pfam.xfam.org/family/PF01609 Pfam PF05598 http://pfam.xfam.org/family/PF05598 Phobius swissprot:INH14_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INH14_ECOLI PhylomeDB P0CE61 http://phylomedb.org/?seqid=P0CE61 ProteinModelPortal P0CE61 http://www.proteinmodelportal.org/query/uniprot/P0CE61 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 RefSeq WP_000019403 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000019403 SMR P0CE61 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0CE61 STRING 511145.b3505 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3505&targetmode=cogs UniProtKB INH14_ECOLI http://www.uniprot.org/uniprot/INH14_ECOLI UniProtKB-AC P0CE61 http://www.uniprot.org/uniprot/P0CE61 charge swissprot:INH14_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INH14_ECOLI eggNOG COG3039 http://eggnogapi.embl.de/nog_data/html/tree/COG3039 eggNOG ENOG4105F2I http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F2I epestfind swissprot:INH14_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INH14_ECOLI garnier swissprot:INH14_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INH14_ECOLI helixturnhelix swissprot:INH14_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INH14_ECOLI hmoment swissprot:INH14_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INH14_ECOLI iep swissprot:INH14_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INH14_ECOLI inforesidue swissprot:INH14_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INH14_ECOLI octanol swissprot:INH14_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INH14_ECOLI pepcoil swissprot:INH14_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INH14_ECOLI pepdigest swissprot:INH14_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INH14_ECOLI pepinfo swissprot:INH14_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INH14_ECOLI pepnet swissprot:INH14_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INH14_ECOLI pepstats swissprot:INH14_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INH14_ECOLI pepwheel swissprot:INH14_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INH14_ECOLI pepwindow swissprot:INH14_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INH14_ECOLI sigcleave swissprot:INH14_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INH14_ECOLI ## Database ID URL or Descriptions # AltName BCSB_ECOLI Cellulose synthase regulatory subunit # BioGrid 4262529 269 # EcoGene EG12259 bcsB # FUNCTION BCSB_ECOLI Binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP). {ECO 0000250}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006011 UDP-glucose metabolic process; IEA:InterPro. # GO_process GO:0030244 cellulose biosynthetic process; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # IntAct P37652 4 # InterPro IPR003920 Cell_synth_B # InterPro IPR018513 Cell_synthase_bac # MISCELLANEOUS BCSB_ECOLI The genes bscA, bcsB, bcsZ and bcsC are constitutively transcribed but cellulose synthesis occurs only when AdrA, a putative transmembrane protein regulated by AgfD, is expressed. Cellulose production is abolished in E.coli K12. # Organism BCSB_ECOLI Escherichia coli (strain K12) # PATHWAY BCSB_ECOLI Glycan metabolism; bacterial cellulose biosynthesis. # PATRIC 32122530 VBIEscCol129921_3643 # PIR G65151 G65151 # PRINTS PR01440 CELLSNTHASEB # Pfam PF03170 BcsB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BCSB_ECOLI Cyclic di-GMP-binding protein # RefSeq NP_417989 NC_000913.3 # RefSeq WP_001407405 NZ_LN832404.1 # SIMILARITY Belongs to the AcsB/BcsB family. {ECO 0000305}. # SUBCELLULAR LOCATION BCSB_ECOLI Cell inner membrane; Single-pass type I membrane protein. # SUBUNIT Tightly associated with the cellulose synthase catalytic subunit. {ECO 0000250}. # TCDB 4.D.3.1 the glycan glucosyl transferase (opgh) family # eggNOG ENOG4107EEX Bacteria # eggNOG ENOG410XNNB LUCA BLAST swissprot:BCSB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BCSB_ECOLI BioCyc ECOL316407:JW3500-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3500-MONOMER BioCyc EcoCyc:EG12259-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12259-MONOMER BioCyc MetaCyc:EG12259-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12259-MONOMER DIP DIP-12386N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12386N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2001.02337.x http://dx.doi.org/10.1046/j.1365-2958.2001.02337.x DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2168 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2168 EcoGene EG12259 http://www.ecogene.org/geneInfo.php?eg_id=EG12259 EnsemblBacteria AAC76557 http://www.ensemblgenomes.org/id/AAC76557 EnsemblBacteria AAC76557 http://www.ensemblgenomes.org/id/AAC76557 EnsemblBacteria BAE77762 http://www.ensemblgenomes.org/id/BAE77762 EnsemblBacteria BAE77762 http://www.ensemblgenomes.org/id/BAE77762 EnsemblBacteria BAE77762 http://www.ensemblgenomes.org/id/BAE77762 EnsemblBacteria b3532 http://www.ensemblgenomes.org/id/b3532 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006011 GO_process GO:0030244 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030244 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 948045 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948045 HOGENOM HOG000259077 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000259077&db=HOGENOM6 InParanoid P37652 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37652 IntAct P37652 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37652* InterPro IPR003920 http://www.ebi.ac.uk/interpro/entry/IPR003920 InterPro IPR018513 http://www.ebi.ac.uk/interpro/entry/IPR018513 KEGG_Gene ecj:JW3500 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3500 KEGG_Gene eco:b3532 http://www.genome.jp/dbget-bin/www_bget?eco:b3532 OMA FQYMNPM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FQYMNPM PRINTS PR01440 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01440 PSORT swissprot:BCSB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BCSB_ECOLI PSORT-B swissprot:BCSB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BCSB_ECOLI PSORT2 swissprot:BCSB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BCSB_ECOLI Pfam PF03170 http://pfam.xfam.org/family/PF03170 Phobius swissprot:BCSB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BCSB_ECOLI ProteinModelPortal P37652 http://www.proteinmodelportal.org/query/uniprot/P37652 PubMed 11260463 http://www.ncbi.nlm.nih.gov/pubmed/11260463 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417989 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417989 RefSeq WP_001407405 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001407405 STRING 511145.b3532 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3532&targetmode=cogs TCDB 4.D.3.1 http://www.tcdb.org/search/result.php?tc=4.D.3.1 UniProtKB BCSB_ECOLI http://www.uniprot.org/uniprot/BCSB_ECOLI UniProtKB-AC P37652 http://www.uniprot.org/uniprot/P37652 charge swissprot:BCSB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BCSB_ECOLI eggNOG ENOG4107EEX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107EEX eggNOG ENOG410XNNB http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNNB epestfind swissprot:BCSB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BCSB_ECOLI garnier swissprot:BCSB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BCSB_ECOLI helixturnhelix swissprot:BCSB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BCSB_ECOLI hmoment swissprot:BCSB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BCSB_ECOLI iep swissprot:BCSB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BCSB_ECOLI inforesidue swissprot:BCSB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BCSB_ECOLI octanol swissprot:BCSB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BCSB_ECOLI pepcoil swissprot:BCSB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BCSB_ECOLI pepdigest swissprot:BCSB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BCSB_ECOLI pepinfo swissprot:BCSB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BCSB_ECOLI pepnet swissprot:BCSB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BCSB_ECOLI pepstats swissprot:BCSB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BCSB_ECOLI pepwheel swissprot:BCSB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BCSB_ECOLI pepwindow swissprot:BCSB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BCSB_ECOLI sigcleave swissprot:BCSB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BCSB_ECOLI ## Database ID URL or Descriptions # AltName Bacteriophage Q beta RNA-directed RNA polymerase subunit IV {ECO:0000303|PubMed 816798} # BioGrid 4260795 5 # EcoGene EG11033 tsf # FUNCTION EFTS_ECOLI Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. # FUNCTION EFTS_ECOLI In case of infection by bacteriophage Qbeta, part of the viral RNA-dependent RNA polymerase complex. With EF-Tu may provide a stabilizing scaffold for the beta (catalytic) subunit, implicated in the elongation step of viral RNA synthesis where it fixes EF-Tu in an open conformation. {ECO 0000269|PubMed 20534494, ECO 0000269|PubMed 20798060, ECO 0000269|PubMed 22245970, ECO 0000269|PubMed 22884418, ECO 0000269|PubMed 25122749, ECO 0000269|PubMed 816798}. # GO_component GO:0005737 cytoplasm; IDA:UniProtKB. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0003746 translation elongation factor activity; IBA:GO_Central. # GO_function GO:0005085 guanyl-nucleotide exchange factor activity; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IDA:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008135 translation factor activity, RNA binding # GOslim_function GO:0043167 ion binding # Gene3D 3.30.479.20 -; 2. # HAMAP MF_00050 EF_Ts # INTERACTION EFTS_ECOLI P0CE47 tufA; NbExp=7; IntAct=EBI-301164, EBI-301077; # IntAct P0A6P1 10 # InterPro IPR001816 Transl_elong_EFTs/EF1B # InterPro IPR009060 UBA-like # InterPro IPR014039 Transl_elong_EFTs/EF1B_dimer # InterPro IPR018101 Transl_elong_Ts_CS # KEGG_Brite ko03012 Translation factors # MASS SPECTROMETRY Mass=30294; Mass_error=6; Method=Electrospray; Range=2-283; Evidence={ECO:0000269|PubMed 7615087}; # MISCELLANEOUS EFTS_ECOLI In order to produce high amounts of bacteriophage Qbeta RNA polymerase catalytic core, a fusion protein consisting of tsf-tufB-replicase with a cleavable linker between tufB and the viral replicase subunit is frequently used. {ECO 0000269|PubMed 16781472, ECO 0000269|PubMed 20798060, ECO 0000269|PubMed 22245970, ECO 0000269|PubMed 22884418, ECO 0000269|PubMed 25122749}. # Organism EFTS_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11741 PTHR11741 # PATRIC 32115449 VBIEscCol129921_0176 # PDB 1EFU X-ray; 2.50 A; B/D=2-283 # PDB 3AGP X-ray; 2.80 A; A=1-283 # PDB 3AGQ X-ray; 3.22 A; A=1-283 # PDB 3AVT X-ray; 2.61 A; A=1-283 # PDB 3AVU X-ray; 2.91 A; A=1-283 # PDB 3AVV X-ray; 3.12 A; A=1-283 # PDB 3AVW X-ray; 2.60 A; A=1-283 # PDB 3AVX X-ray; 2.41 A; A=1-283 # PDB 3AVY X-ray; 2.62 A; A=1-283 # PDB 3MMP X-ray; 2.50 A; A/C=1-283 # PDB 3VNU X-ray; 3.20 A; A=1-283 # PDB 3VNV X-ray; 2.60 A; A=1-283 # PDB 4FWT X-ray; 3.20 A; A=1-283 # PDB 4PC3 X-ray; 1.83 A; C/D=2-283 # PDB 4PC7 X-ray; 3.60 A; C=2-283 # PDB 4Q7J X-ray; 2.90 A; A/E=2-283 # PDB 4R71 X-ray; 3.21 A; A/C=1-283 # PIR A03525 EFECS # PROSITE PS01126 EF_TS_1 # PROSITE PS01127 EF_TS_2 # Pfam PF00889 EF_TS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EFTS_ECOLI Elongation factor Ts # RefSeq NP_414712 NC_000913.3 # RefSeq WP_000818114 NZ_LN832404.1 # SIMILARITY Belongs to the EF-Ts family. {ECO 0000305}. # SUBCELLULAR LOCATION EFTS_ECOLI Cytoplasm. # SUBUNIT EFTS_ECOLI Heterotetramer composed of two EF-Ts.EF-Tu dimer complexes. In case of infection by bacteriophage Qbeta, part of the viral RNA-dependent RNA polymerase complex, the other subunits are the viral replicase catalytic subunit (AC P14647), host ribosomal protein S1 and EF-Tu (PubMed 816798). {ECO 0000269|PubMed 20534494, ECO 0000269|PubMed 20798060, ECO 0000269|PubMed 22245970, ECO 0000269|PubMed 22884418, ECO 0000269|PubMed 25122749, ECO 0000269|PubMed 816798}. # SUPFAM SSF46934 SSF46934 # SUPFAM SSF54713 SSF54713; 2 # TIGRFAMs TIGR00116 tsf # eggNOG COG0264 LUCA # eggNOG ENOG4105CU7 Bacteria BLAST swissprot:EFTS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EFTS_ECOLI BioCyc ECOL316407:JW0165-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0165-MONOMER BioCyc EcoCyc:EG11033-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11033-MONOMER COG COG0264 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0264 DIP DIP-31835N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31835N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1998.1726 http://dx.doi.org/10.1006/jmbi.1998.1726 DOI 10.1016/0014-5793(95)00597-3 http://dx.doi.org/10.1016/0014-5793(95)00597-3 DOI 10.1016/j.str.2012.07.004 http://dx.doi.org/10.1016/j.str.2012.07.004 DOI 10.1038/379511a0 http://dx.doi.org/10.1038/379511a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsmb.2204 http://dx.doi.org/10.1038/nsmb.2204 DOI 10.1073/pnas.1003015107 http://dx.doi.org/10.1073/pnas.1003015107 DOI 10.1073/pnas.1006559107 http://dx.doi.org/10.1073/pnas.1006559107 DOI 10.1074/jbc.273.8.4556 http://dx.doi.org/10.1074/jbc.273.8.4556 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1093/nar/9.16.4163 http://dx.doi.org/10.1093/nar/9.16.4163 DOI 10.1093/nar/gku745 http://dx.doi.org/10.1093/nar/gku745 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1263/jbb.101.421 http://dx.doi.org/10.1263/jbb.101.421 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D13334 http://www.ebi.ac.uk/ena/data/view/D13334 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EMBL V00343 http://www.ebi.ac.uk/ena/data/view/V00343 EchoBASE EB1026 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1026 EcoGene EG11033 http://www.ecogene.org/geneInfo.php?eg_id=EG11033 EnsemblBacteria AAC73281 http://www.ensemblgenomes.org/id/AAC73281 EnsemblBacteria AAC73281 http://www.ensemblgenomes.org/id/AAC73281 EnsemblBacteria BAB96746 http://www.ensemblgenomes.org/id/BAB96746 EnsemblBacteria BAB96746 http://www.ensemblgenomes.org/id/BAB96746 EnsemblBacteria BAB96746 http://www.ensemblgenomes.org/id/BAB96746 EnsemblBacteria b0170 http://www.ensemblgenomes.org/id/b0170 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0003746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003746 GO_function GO:0005085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005085 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008135 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008135 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.30.479.20 http://www.cathdb.info/version/latest/superfamily/3.30.479.20 GeneID 944866 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944866 HAMAP MF_00050 http://hamap.expasy.org/unirule/MF_00050 HOGENOM HOG000220986 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220986&db=HOGENOM6 InParanoid P0A6P1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6P1 IntAct P0A6P1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6P1* InterPro IPR001816 http://www.ebi.ac.uk/interpro/entry/IPR001816 InterPro IPR009060 http://www.ebi.ac.uk/interpro/entry/IPR009060 InterPro IPR014039 http://www.ebi.ac.uk/interpro/entry/IPR014039 InterPro IPR018101 http://www.ebi.ac.uk/interpro/entry/IPR018101 KEGG_Brite ko03012 http://www.genome.jp/dbget-bin/www_bget?ko03012 KEGG_Gene ecj:JW0165 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0165 KEGG_Gene eco:b0170 http://www.genome.jp/dbget-bin/www_bget?eco:b0170 KEGG_Orthology KO:K02357 http://www.genome.jp/dbget-bin/www_bget?KO:K02357 MINT MINT-1273899 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1273899 OMA FIMEPKK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FIMEPKK PANTHER PTHR11741 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11741 PDB 1EFU http://www.ebi.ac.uk/pdbe-srv/view/entry/1EFU PDB 3AGP http://www.ebi.ac.uk/pdbe-srv/view/entry/3AGP PDB 3AGQ http://www.ebi.ac.uk/pdbe-srv/view/entry/3AGQ PDB 3AVT http://www.ebi.ac.uk/pdbe-srv/view/entry/3AVT PDB 3AVU http://www.ebi.ac.uk/pdbe-srv/view/entry/3AVU PDB 3AVV http://www.ebi.ac.uk/pdbe-srv/view/entry/3AVV PDB 3AVW http://www.ebi.ac.uk/pdbe-srv/view/entry/3AVW PDB 3AVX http://www.ebi.ac.uk/pdbe-srv/view/entry/3AVX PDB 3AVY http://www.ebi.ac.uk/pdbe-srv/view/entry/3AVY PDB 3MMP http://www.ebi.ac.uk/pdbe-srv/view/entry/3MMP PDB 3VNU http://www.ebi.ac.uk/pdbe-srv/view/entry/3VNU PDB 3VNV http://www.ebi.ac.uk/pdbe-srv/view/entry/3VNV PDB 4FWT http://www.ebi.ac.uk/pdbe-srv/view/entry/4FWT PDB 4PC3 http://www.ebi.ac.uk/pdbe-srv/view/entry/4PC3 PDB 4PC7 http://www.ebi.ac.uk/pdbe-srv/view/entry/4PC7 PDB 4Q7J http://www.ebi.ac.uk/pdbe-srv/view/entry/4Q7J PDB 4R71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4R71 PDBsum 1EFU http://www.ebi.ac.uk/pdbsum/1EFU PDBsum 3AGP http://www.ebi.ac.uk/pdbsum/3AGP PDBsum 3AGQ http://www.ebi.ac.uk/pdbsum/3AGQ PDBsum 3AVT http://www.ebi.ac.uk/pdbsum/3AVT PDBsum 3AVU http://www.ebi.ac.uk/pdbsum/3AVU PDBsum 3AVV http://www.ebi.ac.uk/pdbsum/3AVV PDBsum 3AVW http://www.ebi.ac.uk/pdbsum/3AVW PDBsum 3AVX http://www.ebi.ac.uk/pdbsum/3AVX PDBsum 3AVY http://www.ebi.ac.uk/pdbsum/3AVY PDBsum 3MMP http://www.ebi.ac.uk/pdbsum/3MMP PDBsum 3VNU http://www.ebi.ac.uk/pdbsum/3VNU PDBsum 3VNV http://www.ebi.ac.uk/pdbsum/3VNV PDBsum 4FWT http://www.ebi.ac.uk/pdbsum/4FWT PDBsum 4PC3 http://www.ebi.ac.uk/pdbsum/4PC3 PDBsum 4PC7 http://www.ebi.ac.uk/pdbsum/4PC7 PDBsum 4Q7J http://www.ebi.ac.uk/pdbsum/4Q7J PDBsum 4R71 http://www.ebi.ac.uk/pdbsum/4R71 PROSITE PS01126 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01126 PROSITE PS01127 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01127 PSORT swissprot:EFTS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EFTS_ECOLI PSORT-B swissprot:EFTS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EFTS_ECOLI PSORT2 swissprot:EFTS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EFTS_ECOLI Pfam PF00889 http://pfam.xfam.org/family/PF00889 Phobius swissprot:EFTS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EFTS_ECOLI PhylomeDB P0A6P1 http://phylomedb.org/?seqid=P0A6P1 ProteinModelPortal P0A6P1 http://www.proteinmodelportal.org/query/uniprot/P0A6P1 PubMed 1447125 http://www.ncbi.nlm.nih.gov/pubmed/1447125 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16781472 http://www.ncbi.nlm.nih.gov/pubmed/16781472 PubMed 20534494 http://www.ncbi.nlm.nih.gov/pubmed/20534494 PubMed 20798060 http://www.ncbi.nlm.nih.gov/pubmed/20798060 PubMed 22245970 http://www.ncbi.nlm.nih.gov/pubmed/22245970 PubMed 22884418 http://www.ncbi.nlm.nih.gov/pubmed/22884418 PubMed 25122749 http://www.ncbi.nlm.nih.gov/pubmed/25122749 PubMed 2661533 http://www.ncbi.nlm.nih.gov/pubmed/2661533 PubMed 6272196 http://www.ncbi.nlm.nih.gov/pubmed/6272196 PubMed 7615087 http://www.ncbi.nlm.nih.gov/pubmed/7615087 PubMed 816798 http://www.ncbi.nlm.nih.gov/pubmed/816798 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 8596629 http://www.ncbi.nlm.nih.gov/pubmed/8596629 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9468511 http://www.ncbi.nlm.nih.gov/pubmed/9468511 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 RefSeq NP_414712 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414712 RefSeq WP_000818114 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000818114 SMR P0A6P1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6P1 STRING 511145.b0170 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0170&targetmode=cogs STRING COG0264 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0264&targetmode=cogs SUPFAM SSF46934 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46934 SUPFAM SSF54713 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54713 SWISS-2DPAGE P0A6P1 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A6P1 TIGRFAMs TIGR00116 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00116 UniProtKB EFTS_ECOLI http://www.uniprot.org/uniprot/EFTS_ECOLI UniProtKB-AC P0A6P1 http://www.uniprot.org/uniprot/P0A6P1 charge swissprot:EFTS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EFTS_ECOLI eggNOG COG0264 http://eggnogapi.embl.de/nog_data/html/tree/COG0264 eggNOG ENOG4105CU7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CU7 epestfind swissprot:EFTS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EFTS_ECOLI garnier swissprot:EFTS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EFTS_ECOLI helixturnhelix swissprot:EFTS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EFTS_ECOLI hmoment swissprot:EFTS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EFTS_ECOLI iep swissprot:EFTS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EFTS_ECOLI inforesidue swissprot:EFTS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EFTS_ECOLI octanol swissprot:EFTS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EFTS_ECOLI pepcoil swissprot:EFTS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EFTS_ECOLI pepdigest swissprot:EFTS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EFTS_ECOLI pepinfo swissprot:EFTS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EFTS_ECOLI pepnet swissprot:EFTS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EFTS_ECOLI pepstats swissprot:EFTS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EFTS_ECOLI pepwheel swissprot:EFTS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EFTS_ECOLI pepwindow swissprot:EFTS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EFTS_ECOLI sigcleave swissprot:EFTS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EFTS_ECOLI ## Database ID URL or Descriptions # AltName MSRA_ECOLI Peptide-methionine (S)-S-oxide reductase # BRENDA 1.8.4.11 2026 # BioGrid 4259307 6 # CATALYTIC ACTIVITY MSRA_ECOLI L-methionine + thioredoxin disulfide + H(2)O = L-methionine (S)-S-oxide + thioredoxin. # CATALYTIC ACTIVITY MSRA_ECOLI Peptide-L-methionine + thioredoxin disulfide + H(2)O = peptide-L-methionine (S)-S-oxide + thioredoxin. # EcoGene EG11433 msrA # FUNCTION MSRA_ECOLI Could have an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008113 peptide-methionine (S)-S-oxide reductase activity; IDA:EcoCyc. # GO_function GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor; IMP:EcoCyc. # GO_function GO:0036456 L-methionine-(S)-S-oxide reductase activity; IDA:EcoCyc. # GO_process GO:0006464 cellular protein modification process; IEA:UniProtKB-HAMAP. # GO_process GO:0006979 response to oxidative stress; IMP:EcoCyc. # GO_process GO:0030091 protein repair; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # Gene3D 3.30.1060.10 -; 1. # HAMAP MF_01401 MsrA # IntAct P0A744 4 # InterPro IPR002569 Met_Sox_Rdtase_MsrA # InterPro IPR028427 Met_Sox_Rdtase # KEGG_Brite ko01000 Enzymes # Organism MSRA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10173 PTHR10173 # PATRIC 32124013 VBIEscCol129921_4351 # PDB 1FF3 X-ray; 1.90 A; A/B/C=2-212 # PDB 2GT3 NMR; -; A=1-212 # PDB 2IEM NMR; -; A=2-212 # PIR S56444 S56444 # Pfam PF01625 PMSR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MSRA_ECOLI Peptide methionine sulfoxide reductase MsrA # RefSeq NP_418640 NC_000913.3 # RefSeq WP_001295196 NZ_LN832404.1 # SIMILARITY Belongs to the MsrA Met sulfoxide reductase family. {ECO 0000305}. # SUPFAM SSF55068 SSF55068 # TIGRFAMs TIGR00401 msrA # eggNOG COG0225 LUCA # eggNOG ENOG4107QXP Bacteria BLAST swissprot:MSRA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MSRA_ECOLI BioCyc ECOL316407:JW4178-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4178-MONOMER BioCyc EcoCyc:EG11433-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11433-MONOMER BioCyc MetaCyc:EG11433-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11433-MONOMER COG COG0225 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0225 DOI 10.1016/S0969-2126(00)00526-8 http://dx.doi.org/10.1016/S0969-2126(00)00526-8 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M006137200 http://dx.doi.org/10.1074/jbc.M006137200 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.8.4.11 http://www.genome.jp/dbget-bin/www_bget?EC:1.8.4.11 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M89992 http://www.ebi.ac.uk/ena/data/view/M89992 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 1.8.4.11 http://enzyme.expasy.org/EC/1.8.4.11 EchoBASE EB1403 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1403 EcoGene EG11433 http://www.ecogene.org/geneInfo.php?eg_id=EG11433 EnsemblBacteria AAC77176 http://www.ensemblgenomes.org/id/AAC77176 EnsemblBacteria AAC77176 http://www.ensemblgenomes.org/id/AAC77176 EnsemblBacteria BAE78220 http://www.ensemblgenomes.org/id/BAE78220 EnsemblBacteria BAE78220 http://www.ensemblgenomes.org/id/BAE78220 EnsemblBacteria BAE78220 http://www.ensemblgenomes.org/id/BAE78220 EnsemblBacteria b4219 http://www.ensemblgenomes.org/id/b4219 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008113 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008113 GO_function GO:0016671 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016671 GO_function GO:0036456 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036456 GO_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GO_process GO:0006979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979 GO_process GO:0030091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030091 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.30.1060.10 http://www.cathdb.info/version/latest/superfamily/3.30.1060.10 GeneID 948734 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948734 HAMAP MF_01401 http://hamap.expasy.org/unirule/MF_01401 HOGENOM HOG000263862 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000263862&db=HOGENOM6 InParanoid P0A744 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A744 IntAct P0A744 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A744* IntEnz 1.8.4.11 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.8.4.11 InterPro IPR002569 http://www.ebi.ac.uk/interpro/entry/IPR002569 InterPro IPR028427 http://www.ebi.ac.uk/interpro/entry/IPR028427 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4178 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4178 KEGG_Gene eco:b4219 http://www.genome.jp/dbget-bin/www_bget?eco:b4219 KEGG_Orthology KO:K07304 http://www.genome.jp/dbget-bin/www_bget?KO:K07304 OMA MVLRSEI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MVLRSEI PANTHER PTHR10173 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10173 PDB 1FF3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1FF3 PDB 2GT3 http://www.ebi.ac.uk/pdbe-srv/view/entry/2GT3 PDB 2IEM http://www.ebi.ac.uk/pdbe-srv/view/entry/2IEM PDBsum 1FF3 http://www.ebi.ac.uk/pdbsum/1FF3 PDBsum 2GT3 http://www.ebi.ac.uk/pdbsum/2GT3 PDBsum 2IEM http://www.ebi.ac.uk/pdbsum/2IEM PSORT swissprot:MSRA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MSRA_ECOLI PSORT-B swissprot:MSRA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MSRA_ECOLI PSORT2 swissprot:MSRA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MSRA_ECOLI Pfam PF01625 http://pfam.xfam.org/family/PF01625 Phobius swissprot:MSRA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MSRA_ECOLI PhylomeDB P0A744 http://phylomedb.org/?seqid=P0A744 ProteinModelPortal P0A744 http://www.proteinmodelportal.org/query/uniprot/P0A744 PubMed 10964927 http://www.ncbi.nlm.nih.gov/pubmed/10964927 PubMed 11080639 http://www.ncbi.nlm.nih.gov/pubmed/11080639 PubMed 1386361 http://www.ncbi.nlm.nih.gov/pubmed/1386361 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418640 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418640 RefSeq WP_001295196 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295196 SMR P0A744 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A744 STRING 511145.b4219 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4219&targetmode=cogs STRING COG0225 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0225&targetmode=cogs SUPFAM SSF55068 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55068 TIGRFAMs TIGR00401 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00401 UniProtKB MSRA_ECOLI http://www.uniprot.org/uniprot/MSRA_ECOLI UniProtKB-AC P0A744 http://www.uniprot.org/uniprot/P0A744 charge swissprot:MSRA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MSRA_ECOLI eggNOG COG0225 http://eggnogapi.embl.de/nog_data/html/tree/COG0225 eggNOG ENOG4107QXP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QXP epestfind swissprot:MSRA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MSRA_ECOLI garnier swissprot:MSRA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MSRA_ECOLI helixturnhelix swissprot:MSRA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MSRA_ECOLI hmoment swissprot:MSRA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MSRA_ECOLI iep swissprot:MSRA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MSRA_ECOLI inforesidue swissprot:MSRA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MSRA_ECOLI octanol swissprot:MSRA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MSRA_ECOLI pepcoil swissprot:MSRA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MSRA_ECOLI pepdigest swissprot:MSRA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MSRA_ECOLI pepinfo swissprot:MSRA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MSRA_ECOLI pepnet swissprot:MSRA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MSRA_ECOLI pepstats swissprot:MSRA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MSRA_ECOLI pepwheel swissprot:MSRA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MSRA_ECOLI pepwindow swissprot:MSRA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MSRA_ECOLI sigcleave swissprot:MSRA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MSRA_ECOLI ## Database ID URL or Descriptions # AltName YCEA_ECOLI ORF39.9 # BioGrid 4262843 121 # EcoGene EG11116 yceA # Gene3D 3.40.250.10 -; 1. # HAMAP MF_00469 UPF0176 # INDUCTION YCEA_ECOLI Is expressed at all temperatures, but accumulation of yceA transcripts decline with raising temperature. Thus, its expression is repressed by heat shock. # IntAct P24188 7 # InterPro IPR001763 Rhodanese-like_dom # InterPro IPR020936 UPF0176 # InterPro IPR022111 Rhodanese_C # Organism YCEA_ECOLI Escherichia coli (strain K12) # PATRIC 32117347 VBIEscCol129921_1096 # PIR D64848 D64848 # PROSITE PS50206 RHODANESE_3 # Pfam PF00581 Rhodanese # Pfam PF12368 Rhodanese_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCEA_ECOLI UPF0176 protein YceA # RefSeq NP_415573 NC_000913.3 # RefSeq WP_001144615 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0176 family. {ECO 0000305}. # SIMILARITY Contains 1 rhodanese domain. {ECO 0000305}. # SMART SM00450 RHOD # SUPFAM SSF52821 SSF52821 # eggNOG COG1054 LUCA # eggNOG ENOG4105C72 Bacteria BLAST swissprot:YCEA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCEA_ECOLI BioCyc ECOL316407:JW1042-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1042-MONOMER BioCyc EcoCyc:EG11116-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11116-MONOMER COG COG1054 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1054 DIP DIP-11521N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11521N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1991.tb02159.x http://dx.doi.org/10.1111/j.1365-2958.1991.tb02159.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X61000 http://www.ebi.ac.uk/ena/data/view/X61000 EchoBASE EB1106 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1106 EcoGene EG11116 http://www.ecogene.org/geneInfo.php?eg_id=EG11116 EnsemblBacteria AAC74139 http://www.ensemblgenomes.org/id/AAC74139 EnsemblBacteria AAC74139 http://www.ensemblgenomes.org/id/AAC74139 EnsemblBacteria BAA35853 http://www.ensemblgenomes.org/id/BAA35853 EnsemblBacteria BAA35853 http://www.ensemblgenomes.org/id/BAA35853 EnsemblBacteria BAA35853 http://www.ensemblgenomes.org/id/BAA35853 EnsemblBacteria b1055 http://www.ensemblgenomes.org/id/b1055 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.40.250.10 http://www.cathdb.info/version/latest/superfamily/3.40.250.10 GeneID 945601 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945601 HAMAP MF_00469 http://hamap.expasy.org/unirule/MF_00469 HOGENOM HOG000034809 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000034809&db=HOGENOM6 InParanoid P24188 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P24188 IntAct P24188 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P24188* InterPro IPR001763 http://www.ebi.ac.uk/interpro/entry/IPR001763 InterPro IPR020936 http://www.ebi.ac.uk/interpro/entry/IPR020936 InterPro IPR022111 http://www.ebi.ac.uk/interpro/entry/IPR022111 KEGG_Gene ecj:JW1042 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1042 KEGG_Gene eco:b1055 http://www.genome.jp/dbget-bin/www_bget?eco:b1055 KEGG_Orthology KO:K07146 http://www.genome.jp/dbget-bin/www_bget?KO:K07146 MINT MINT-1227067 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1227067 OMA CDTHVNC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CDTHVNC PROSITE PS50206 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50206 PSORT swissprot:YCEA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCEA_ECOLI PSORT-B swissprot:YCEA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCEA_ECOLI PSORT2 swissprot:YCEA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCEA_ECOLI Pfam PF00581 http://pfam.xfam.org/family/PF00581 Pfam PF12368 http://pfam.xfam.org/family/PF12368 Phobius swissprot:YCEA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCEA_ECOLI PhylomeDB P24188 http://phylomedb.org/?seqid=P24188 ProteinModelPortal P24188 http://www.proteinmodelportal.org/query/uniprot/P24188 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1840644 http://www.ncbi.nlm.nih.gov/pubmed/1840644 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415573 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415573 RefSeq WP_001144615 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001144615 SMART SM00450 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00450 SMR P24188 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P24188 STRING 511145.b1055 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1055&targetmode=cogs STRING COG1054 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1054&targetmode=cogs SUPFAM SSF52821 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52821 UniProtKB YCEA_ECOLI http://www.uniprot.org/uniprot/YCEA_ECOLI UniProtKB-AC P24188 http://www.uniprot.org/uniprot/P24188 charge swissprot:YCEA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCEA_ECOLI eggNOG COG1054 http://eggnogapi.embl.de/nog_data/html/tree/COG1054 eggNOG ENOG4105C72 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C72 epestfind swissprot:YCEA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCEA_ECOLI garnier swissprot:YCEA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCEA_ECOLI helixturnhelix swissprot:YCEA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCEA_ECOLI hmoment swissprot:YCEA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCEA_ECOLI iep swissprot:YCEA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCEA_ECOLI inforesidue swissprot:YCEA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCEA_ECOLI octanol swissprot:YCEA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCEA_ECOLI pepcoil swissprot:YCEA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCEA_ECOLI pepdigest swissprot:YCEA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCEA_ECOLI pepinfo swissprot:YCEA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCEA_ECOLI pepnet swissprot:YCEA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCEA_ECOLI pepstats swissprot:YCEA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCEA_ECOLI pepwheel swissprot:YCEA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCEA_ECOLI pepwindow swissprot:YCEA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCEA_ECOLI sigcleave swissprot:YCEA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCEA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262324 9 # CDD cd04235 AAK_CK # EcoGene EG13057 yqeA # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0008804 carbamate kinase activity; IBA:GO_Central. # GO_process GO:0019546 arginine deiminase pathway; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016301 kinase activity # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # Gene3D 3.40.1160.10 -; 1. # InterPro IPR001048 Asp/Glu/Uridylate_kinase # InterPro IPR003964 Carb_kinase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00330 Arginine and proline metabolism # KEGG_Pathway ko00910 Nitrogen metabolism # Organism ARCL_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30409 PTHR30409 # PATRIC 32121158 VBIEscCol129921_2967 # PIR B65071 B65071 # PIRSF PIRSF000723 Carbamate_kin # Pfam PF00696 AA_kinase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ARCL_ECOLI Carbamate kinase-like protein YqeA # RefSeq NP_417350 NC_000913.3 # RefSeq WP_000037992 NZ_LN832404.1 # SIMILARITY Belongs to the carbamate kinase family. {ECO 0000305}. # SUPFAM SSF53633 SSF53633 # TIGRFAMs TIGR00746 arcC # eggNOG COG0549 LUCA # eggNOG ENOG4105C5B Bacteria BLAST swissprot:ARCL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARCL_ECOLI BioCyc ECOL316407:JW2842-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2842-MONOMER BioCyc EcoCyc:G7493-MONOMER http://biocyc.org/getid?id=EcoCyc:G7493-MONOMER COG COG0549 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0549 DIP DIP-12850N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12850N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 EchoBASE EB2869 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2869 EcoGene EG13057 http://www.ecogene.org/geneInfo.php?eg_id=EG13057 EnsemblBacteria AAC75912 http://www.ensemblgenomes.org/id/AAC75912 EnsemblBacteria AAC75912 http://www.ensemblgenomes.org/id/AAC75912 EnsemblBacteria BAE76940 http://www.ensemblgenomes.org/id/BAE76940 EnsemblBacteria BAE76940 http://www.ensemblgenomes.org/id/BAE76940 EnsemblBacteria BAE76940 http://www.ensemblgenomes.org/id/BAE76940 EnsemblBacteria b2874 http://www.ensemblgenomes.org/id/b2874 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008804 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008804 GO_process GO:0019546 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019546 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 3.40.1160.10 http://www.cathdb.info/version/latest/superfamily/3.40.1160.10 GeneID 947358 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947358 HOGENOM HOG000277403 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000277403&db=HOGENOM6 InParanoid Q46807 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46807 InterPro IPR001048 http://www.ebi.ac.uk/interpro/entry/IPR001048 InterPro IPR003964 http://www.ebi.ac.uk/interpro/entry/IPR003964 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2842 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2842 KEGG_Gene eco:b2874 http://www.genome.jp/dbget-bin/www_bget?eco:b2874 KEGG_Orthology KO:K00926 http://www.genome.jp/dbget-bin/www_bget?KO:K00926 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00330 http://www.genome.jp/kegg-bin/show_pathway?ko00330 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Reaction rn:R00150 http://www.genome.jp/dbget-bin/www_bget?rn:R00150 KEGG_Reaction rn:R01395 http://www.genome.jp/dbget-bin/www_bget?rn:R01395 MINT MINT-1322368 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1322368 OMA PQVGQIN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PQVGQIN PANTHER PTHR30409 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30409 PSORT swissprot:ARCL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARCL_ECOLI PSORT-B swissprot:ARCL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARCL_ECOLI PSORT2 swissprot:ARCL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARCL_ECOLI Pfam PF00696 http://pfam.xfam.org/family/PF00696 Phobius swissprot:ARCL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARCL_ECOLI PhylomeDB Q46807 http://phylomedb.org/?seqid=Q46807 ProteinModelPortal Q46807 http://www.proteinmodelportal.org/query/uniprot/Q46807 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417350 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417350 RefSeq WP_000037992 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000037992 SMR Q46807 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46807 STRING 511145.b2874 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2874&targetmode=cogs STRING COG0549 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0549&targetmode=cogs SUPFAM SSF53633 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53633 TIGRFAMs TIGR00746 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00746 UniProtKB ARCL_ECOLI http://www.uniprot.org/uniprot/ARCL_ECOLI UniProtKB-AC Q46807 http://www.uniprot.org/uniprot/Q46807 charge swissprot:ARCL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARCL_ECOLI eggNOG COG0549 http://eggnogapi.embl.de/nog_data/html/tree/COG0549 eggNOG ENOG4105C5B http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C5B epestfind swissprot:ARCL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARCL_ECOLI garnier swissprot:ARCL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARCL_ECOLI helixturnhelix swissprot:ARCL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARCL_ECOLI hmoment swissprot:ARCL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARCL_ECOLI iep swissprot:ARCL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARCL_ECOLI inforesidue swissprot:ARCL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARCL_ECOLI octanol swissprot:ARCL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARCL_ECOLI pepcoil swissprot:ARCL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARCL_ECOLI pepdigest swissprot:ARCL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARCL_ECOLI pepinfo swissprot:ARCL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARCL_ECOLI pepnet swissprot:ARCL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARCL_ECOLI pepstats swissprot:ARCL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARCL_ECOLI pepwheel swissprot:ARCL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARCL_ECOLI pepwindow swissprot:ARCL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARCL_ECOLI sigcleave swissprot:ARCL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARCL_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES PHEA_ECOLI Kinetic parameters KM=45 uM for chorismate (at pH 7.8 and at 37 degrees Celsius, PubMed 4261395) {ECO 0000269|PubMed 4261395, ECO 0000269|Ref.8}; KM=100 uM for prephenate (at pH 7.8 and at 37 degrees Celsius, PubMed 4261395) {ECO 0000269|PubMed 4261395, ECO 0000269|Ref.8}; KM=147 uM for chorismate (at pH 4.9) {ECO 0000269|PubMed 4261395, ECO 0000269|Ref.8}; KM=296 uM for chorismate (at pH 7.5) {ECO 0000269|PubMed 4261395, ECO 0000269|Ref.8}; Temperature dependence Optimum temperature is 7.3 degrees Celsius for chorismate mutase. {ECO 0000269|PubMed 4261395, ECO 0000269|Ref.8}; # BRENDA 5.4.99 2026 # BioGrid 4263461 7 # CATALYTIC ACTIVITY PHEA_ECOLI Chorismate = prephenate. # CATALYTIC ACTIVITY PHEA_ECOLI Prephenate = phenylpyruvate + H(2)O + CO(2). # ENZYME REGULATION Inhibited by L-phenylalanine. {ECO:0000269|PubMed 4261395}. # EcoGene EG10707 pheA # FUNCTION PHEA_ECOLI Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate. {ECO 0000269|PubMed 4261395}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0004106 chorismate mutase activity; IDA:EcoCyc. # GO_function GO:0004664 prephenate dehydratase activity; IDA:EcoCyc. # GO_function GO:0016597 amino acid binding; IEA:InterPro. # GO_process GO:0006571 tyrosine biosynthetic process; IMP:EcoCyc. # GO_process GO:0009094 L-phenylalanine biosynthetic process; IMP:EcoCyc. # GO_process GO:0046417 chorismate metabolic process; IEA:InterPro. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.20.59.10 -; 1. # IntAct P0A9J8 17 # InterPro IPR001086 Preph_deHydtase # InterPro IPR002701 Chorismate_mutase # InterPro IPR002912 ACT_dom # InterPro IPR008242 Chor_mutase/pphenate_deHydtase # InterPro IPR010952 CM_P_1 # InterPro IPR018528 Preph_deHydtase_CS # InterPro IPR020822 Chorismate_mutase_type_II # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis # Organism PHEA_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate step 1/1. # PATHWAY Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate step 1/1. # PATRIC 32120597 VBIEscCol129921_2697 # PDB 1ECM X-ray; 2.20 A; A/B=1-109 # PIR A30261 KMECPW # PIRSF PIRSF001500 Chor_mut_pdt_Ppr # PROSITE PS00857 PREPHENATE_DEHYDR_1 # PROSITE PS00858 PREPHENATE_DEHYDR_2 # PROSITE PS51168 CHORISMATE_MUT_2 # PROSITE PS51171 PREPHENATE_DEHYDR_3 # PROSITE PS51671 ACT # Pfam PF00800 PDT # Pfam PF01817 CM_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PHEA_ECOLI Chorismate mutase # RecName PHEA_ECOLI P-protein # RecName PHEA_ECOLI P-protein # RecName PHEA_ECOLI Prephenate dehydratase # RefSeq NP_417090 NC_000913.3 # RefSeq WP_000200120 NZ_LN832404.1 # SIMILARITY Contains 1 ACT domain. {ECO:0000255|PROSITE- ProRule PRU01007}. # SIMILARITY Contains 1 chorismate mutase domain. {ECO:0000255|PROSITE-ProRule PRU00515}. # SIMILARITY Contains 1 prephenate dehydratase domain. {ECO:0000255|PROSITE-ProRule PRU00517}. # SMART SM00830 CM_2 # SUBCELLULAR LOCATION PHEA_ECOLI Cytoplasm. # SUBUNIT Homodimer. {ECO 0000269|Ref.10}. # SUPFAM SSF48600 SSF48600 # TIGRFAMs TIGR01797 CM_P_1 # UniPathway UPA00120 UER00203 # UniPathway UPA00121 UER00345 # eggNOG COG0077 LUCA # eggNOG COG1605 LUCA # eggNOG ENOG4105CQC Bacteria BLAST swissprot:PHEA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PHEA_ECOLI BioCyc ECOL316407:JW2580-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2580-MONOMER BioCyc EcoCyc:CHORISMUTPREPHENDEHYDRAT-MONOMER http://biocyc.org/getid?id=EcoCyc:CHORISMUTPREPHENDEHYDRAT-MONOMER BioCyc MetaCyc:CHORISMUTPREPHENDEHYDRAT-MONOMER http://biocyc.org/getid?id=MetaCyc:CHORISMUTPREPHENDEHYDRAT-MONOMER COG COG0077 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0077 COG COG1605 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1605 DIP DIP-36017N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36017N DOI 10.1016/0022-2836(84)90269-9 http://dx.doi.org/10.1016/0022-2836(84)90269-9 DOI 10.1021/ja00117a038 http://dx.doi.org/10.1021/ja00117a038 DOI 10.1021/ja953151o http://dx.doi.org/10.1021/ja953151o DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.75.9.4271 http://dx.doi.org/10.1073/pnas.75.9.4271 DOI 10.1074/jbc.273.11.6248 http://dx.doi.org/10.1074/jbc.273.11.6248 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.1.51 http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.51 EC_number EC:5.4.99.5 http://www.genome.jp/dbget-bin/www_bget?EC:5.4.99.5 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M10431 http://www.ebi.ac.uk/ena/data/view/M10431 EMBL M58024 http://www.ebi.ac.uk/ena/data/view/M58024 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00314 http://www.ebi.ac.uk/ena/data/view/V00314 ENZYME 4.2.1.51 http://enzyme.expasy.org/EC/4.2.1.51 ENZYME 5.4.99.5 http://enzyme.expasy.org/EC/5.4.99.5 EchoBASE EB0701 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0701 EcoGene EG10707 http://www.ecogene.org/geneInfo.php?eg_id=EG10707 EnsemblBacteria AAC75648 http://www.ensemblgenomes.org/id/AAC75648 EnsemblBacteria AAC75648 http://www.ensemblgenomes.org/id/AAC75648 EnsemblBacteria BAA16484 http://www.ensemblgenomes.org/id/BAA16484 EnsemblBacteria BAA16484 http://www.ensemblgenomes.org/id/BAA16484 EnsemblBacteria BAA16484 http://www.ensemblgenomes.org/id/BAA16484 EnsemblBacteria b2599 http://www.ensemblgenomes.org/id/b2599 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004106 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004106 GO_function GO:0004664 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004664 GO_function GO:0016597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016597 GO_process GO:0006571 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006571 GO_process GO:0009094 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009094 GO_process GO:0046417 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046417 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.20.59.10 http://www.cathdb.info/version/latest/superfamily/1.20.59.10 GeneID 947081 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947081 HOGENOM HOG000018972 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000018972&db=HOGENOM6 InParanoid P0A9J8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9J8 IntAct P0A9J8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9J8* IntEnz 4.2.1.51 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.51 IntEnz 5.4.99.5 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.4.99.5 InterPro IPR001086 http://www.ebi.ac.uk/interpro/entry/IPR001086 InterPro IPR002701 http://www.ebi.ac.uk/interpro/entry/IPR002701 InterPro IPR002912 http://www.ebi.ac.uk/interpro/entry/IPR002912 InterPro IPR008242 http://www.ebi.ac.uk/interpro/entry/IPR008242 InterPro IPR010952 http://www.ebi.ac.uk/interpro/entry/IPR010952 InterPro IPR018528 http://www.ebi.ac.uk/interpro/entry/IPR018528 InterPro IPR020822 http://www.ebi.ac.uk/interpro/entry/IPR020822 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2580 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2580 KEGG_Gene eco:b2599 http://www.genome.jp/dbget-bin/www_bget?eco:b2599 KEGG_Orthology KO:K14170 http://www.genome.jp/dbget-bin/www_bget?KO:K14170 KEGG_Pathway ko00400 http://www.genome.jp/kegg-bin/show_pathway?ko00400 KEGG_Reaction rn:R00691 http://www.genome.jp/dbget-bin/www_bget?rn:R00691 KEGG_Reaction rn:R01373 http://www.genome.jp/dbget-bin/www_bget?rn:R01373 KEGG_Reaction rn:R01715 http://www.genome.jp/dbget-bin/www_bget?rn:R01715 MINT MINT-1248118 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1248118 OMA WREVMSA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WREVMSA PDB 1ECM http://www.ebi.ac.uk/pdbe-srv/view/entry/1ECM PDBsum 1ECM http://www.ebi.ac.uk/pdbsum/1ECM PROSITE PS00857 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00857 PROSITE PS00858 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00858 PROSITE PS51168 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51168 PROSITE PS51171 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51171 PROSITE PS51671 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51671 PSORT swissprot:PHEA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PHEA_ECOLI PSORT-B swissprot:PHEA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PHEA_ECOLI PSORT2 swissprot:PHEA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PHEA_ECOLI Pfam PF00800 http://pfam.xfam.org/family/PF00800 Pfam PF01817 http://pfam.xfam.org/family/PF01817 Phobius swissprot:PHEA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PHEA_ECOLI PhylomeDB P0A9J8 http://phylomedb.org/?seqid=P0A9J8 ProteinModelPortal P0A9J8 http://www.proteinmodelportal.org/query/uniprot/P0A9J8 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2254312 http://www.ncbi.nlm.nih.gov/pubmed/2254312 PubMed 360214 http://www.ncbi.nlm.nih.gov/pubmed/360214 PubMed 4261395 http://www.ncbi.nlm.nih.gov/pubmed/4261395 PubMed 6396419 http://www.ncbi.nlm.nih.gov/pubmed/6396419 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9497350 http://www.ncbi.nlm.nih.gov/pubmed/9497350 RefSeq NP_417090 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417090 RefSeq WP_000200120 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000200120 SMART SM00830 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00830 SMR P0A9J8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9J8 STRING 511145.b2599 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2599&targetmode=cogs STRING COG0077 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0077&targetmode=cogs STRING COG1605 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1605&targetmode=cogs SUPFAM SSF48600 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48600 TIGRFAMs TIGR01797 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01797 UniProtKB PHEA_ECOLI http://www.uniprot.org/uniprot/PHEA_ECOLI UniProtKB-AC P0A9J8 http://www.uniprot.org/uniprot/P0A9J8 charge swissprot:PHEA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PHEA_ECOLI eggNOG COG0077 http://eggnogapi.embl.de/nog_data/html/tree/COG0077 eggNOG COG1605 http://eggnogapi.embl.de/nog_data/html/tree/COG1605 eggNOG ENOG4105CQC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CQC epestfind swissprot:PHEA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PHEA_ECOLI garnier swissprot:PHEA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PHEA_ECOLI helixturnhelix swissprot:PHEA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PHEA_ECOLI hmoment swissprot:PHEA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PHEA_ECOLI iep swissprot:PHEA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PHEA_ECOLI inforesidue swissprot:PHEA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PHEA_ECOLI octanol swissprot:PHEA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PHEA_ECOLI pepcoil swissprot:PHEA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PHEA_ECOLI pepdigest swissprot:PHEA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PHEA_ECOLI pepinfo swissprot:PHEA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PHEA_ECOLI pepnet swissprot:PHEA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PHEA_ECOLI pepstats swissprot:PHEA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PHEA_ECOLI pepwheel swissprot:PHEA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PHEA_ECOLI pepwindow swissprot:PHEA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PHEA_ECOLI sigcleave swissprot:PHEA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PHEA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259357 22 # DISRUPTION PHENOTYPE Mutation gives no obvious mutant phenotype, but, when combined with xer or dif mutants, leads to slower growth. {ECO:0000269|PubMed 11459952}. # DOMAIN RARA_ECOLI Contains an N-terminal ATP-binding domain, an adjacent helical lid domain, and a C-terminal tetramerization domain. {ECO 0000269|PubMed 21297161}. # EcoGene EG12690 rarA # FUNCTION RARA_ECOLI DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes. {ECO 0000269|PubMed 11459952, ECO 0000269|PubMed 15743409, ECO 0000269|PubMed 21297161}. # GO_component GO:0030894 replisome; IDA:EcoliWiki. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0006261 DNA-dependent DNA replication; IGI:EcoCyc. # GO_process GO:0006310 DNA recombination; IGI:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.300 -; 1. # IntAct P0AAZ4 7 # InterPro IPR003593 AAA+_ATPase # InterPro IPR003959 ATPase_AAA_core # InterPro IPR008921 DNA_pol3_clamp-load_cplx_C # InterPro IPR021886 MgsA_C # InterPro IPR027417 P-loop_NTPase # InterPro IPR032423 AAA_assoc_2 # MISCELLANEOUS Overexpression causes an increase in mutation frequency and inhibits growth of recA mutant. {ECO:0000269|PubMed 15743409}. # Organism RARA_ECOLI Escherichia coli (strain K12) # PATRIC 32116995 VBIEscCol129921_0922 # PDB 3PVS X-ray; 2.50 A; A/B/C/D=1-447 # PIR C64828 C64828 # Pfam PF00004 AAA # Pfam PF12002 MgsA_C # Pfam PF16193 AAA_assoc_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Replication-associated recombination protein A {ECO:0000303|PubMed 11459952} # RefSeq NP_415412 NC_000913.3 # RefSeq WP_000067755 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=X05017; Type=Frameshift; Positions=370; Evidence={ECO 0000305}; # SIMILARITY Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily. {ECO 0000305}. # SMART SM00382 AAA # SUBUNIT Homotetramer. Interacts with the single-stranded DNA- binding protein (ssb). {ECO:0000269|PubMed 21297161}. # SUPFAM SSF48019 SSF48019 # SUPFAM SSF52540 SSF52540 # eggNOG COG2256 LUCA # eggNOG ENOG4105D1H Bacteria BLAST swissprot:RARA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RARA_ECOLI BioCyc ECOL316407:JW0875-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0875-MONOMER BioCyc EcoCyc:EG12690-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12690-MONOMER COG COG2256 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2256 DIP DIP-48151N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48151N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.111008998 http://dx.doi.org/10.1073/pnas.111008998 DOI 10.1074/jbc.M110.210187 http://dx.doi.org/10.1074/jbc.M110.210187 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/15.3.1005 http://dx.doi.org/10.1093/nar/15.3.1005 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1111/j.1365-2443.2005.00831.x http://dx.doi.org/10.1111/j.1365-2443.2005.00831.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D49398 http://www.ebi.ac.uk/ena/data/view/D49398 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X05017 http://www.ebi.ac.uk/ena/data/view/X05017 EchoBASE EB2553 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2553 EcoGene EG12690 http://www.ecogene.org/geneInfo.php?eg_id=EG12690 EnsemblBacteria AAC73978 http://www.ensemblgenomes.org/id/AAC73978 EnsemblBacteria AAC73978 http://www.ensemblgenomes.org/id/AAC73978 EnsemblBacteria BAA35617 http://www.ensemblgenomes.org/id/BAA35617 EnsemblBacteria BAA35617 http://www.ensemblgenomes.org/id/BAA35617 EnsemblBacteria BAA35617 http://www.ensemblgenomes.org/id/BAA35617 EnsemblBacteria b0892 http://www.ensemblgenomes.org/id/b0892 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030894 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030894 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006261 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006261 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945505 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945505 HOGENOM HOG000017623 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000017623&db=HOGENOM6 InParanoid P0AAZ4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAZ4 IntAct P0AAZ4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAZ4* InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR003959 http://www.ebi.ac.uk/interpro/entry/IPR003959 InterPro IPR008921 http://www.ebi.ac.uk/interpro/entry/IPR008921 InterPro IPR021886 http://www.ebi.ac.uk/interpro/entry/IPR021886 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR032423 http://www.ebi.ac.uk/interpro/entry/IPR032423 KEGG_Gene ecj:JW0875 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0875 KEGG_Gene eco:b0892 http://www.genome.jp/dbget-bin/www_bget?eco:b0892 KEGG_Orthology KO:K07478 http://www.genome.jp/dbget-bin/www_bget?KO:K07478 MINT MINT-1224512 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1224512 OMA QHYNLIS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QHYNLIS PDB 3PVS http://www.ebi.ac.uk/pdbe-srv/view/entry/3PVS PDBsum 3PVS http://www.ebi.ac.uk/pdbsum/3PVS PSORT swissprot:RARA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RARA_ECOLI PSORT-B swissprot:RARA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RARA_ECOLI PSORT2 swissprot:RARA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RARA_ECOLI Pfam PF00004 http://pfam.xfam.org/family/PF00004 Pfam PF12002 http://pfam.xfam.org/family/PF12002 Pfam PF16193 http://pfam.xfam.org/family/PF16193 Phobius swissprot:RARA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RARA_ECOLI PhylomeDB P0AAZ4 http://phylomedb.org/?seqid=P0AAZ4 ProteinModelPortal P0AAZ4 http://www.proteinmodelportal.org/query/uniprot/P0AAZ4 PubMed 11459952 http://www.ncbi.nlm.nih.gov/pubmed/11459952 PubMed 15743409 http://www.ncbi.nlm.nih.gov/pubmed/15743409 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21297161 http://www.ncbi.nlm.nih.gov/pubmed/21297161 PubMed 3029694 http://www.ncbi.nlm.nih.gov/pubmed/3029694 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 7628437 http://www.ncbi.nlm.nih.gov/pubmed/7628437 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415412 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415412 RefSeq WP_000067755 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000067755 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P0AAZ4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAZ4 STRING 511145.b0892 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0892&targetmode=cogs STRING COG2256 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2256&targetmode=cogs SUPFAM SSF48019 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48019 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB RARA_ECOLI http://www.uniprot.org/uniprot/RARA_ECOLI UniProtKB-AC P0AAZ4 http://www.uniprot.org/uniprot/P0AAZ4 charge swissprot:RARA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RARA_ECOLI eggNOG COG2256 http://eggnogapi.embl.de/nog_data/html/tree/COG2256 eggNOG ENOG4105D1H http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D1H epestfind swissprot:RARA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RARA_ECOLI garnier swissprot:RARA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RARA_ECOLI helixturnhelix swissprot:RARA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RARA_ECOLI hmoment swissprot:RARA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RARA_ECOLI iep swissprot:RARA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RARA_ECOLI inforesidue swissprot:RARA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RARA_ECOLI octanol swissprot:RARA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RARA_ECOLI pepcoil swissprot:RARA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RARA_ECOLI pepdigest swissprot:RARA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RARA_ECOLI pepinfo swissprot:RARA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RARA_ECOLI pepnet swissprot:RARA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RARA_ECOLI pepstats swissprot:RARA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RARA_ECOLI pepwheel swissprot:RARA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RARA_ECOLI pepwindow swissprot:RARA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RARA_ECOLI sigcleave swissprot:RARA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RARA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259394 15 # EcoGene EG13199 yfjM # IntAct P52128 4 # InterPro IPR011089 DUF1524 # Organism YFJM_ECOLI Escherichia coli (strain K12) # PATRIC 48664664 VBIEscCol107702_2660 # PIR T08641 T08641 # Pfam PF07510 DUF1524 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFJM_ECOLI Uncharacterized protein YfjM # RefSeq NP_417118 NC_000913.3 # RefSeq WP_000502050 NZ_LN832404.1 # eggNOG ENOG4107NPW Bacteria # eggNOG ENOG410ZDU4 LUCA BLAST swissprot:YFJM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFJM_ECOLI BioCyc ECOL316407:JW2610-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2610-MONOMER BioCyc EcoCyc:G7364-MONOMER http://biocyc.org/getid?id=EcoCyc:G7364-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36840 http://www.ebi.ac.uk/ena/data/view/U36840 EchoBASE EB2991 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2991 EcoGene EG13199 http://www.ecogene.org/geneInfo.php?eg_id=EG13199 EnsemblBacteria AAC75677 http://www.ensemblgenomes.org/id/AAC75677 EnsemblBacteria AAC75677 http://www.ensemblgenomes.org/id/AAC75677 EnsemblBacteria BAE76764 http://www.ensemblgenomes.org/id/BAE76764 EnsemblBacteria BAE76764 http://www.ensemblgenomes.org/id/BAE76764 EnsemblBacteria BAE76764 http://www.ensemblgenomes.org/id/BAE76764 EnsemblBacteria b2629 http://www.ensemblgenomes.org/id/b2629 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947108 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947108 IntAct P52128 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P52128* InterPro IPR011089 http://www.ebi.ac.uk/interpro/entry/IPR011089 KEGG_Gene ecj:JW2610 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2610 KEGG_Gene eco:b2629 http://www.genome.jp/dbget-bin/www_bget?eco:b2629 PSORT swissprot:YFJM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFJM_ECOLI PSORT-B swissprot:YFJM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFJM_ECOLI PSORT2 swissprot:YFJM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFJM_ECOLI Pfam PF07510 http://pfam.xfam.org/family/PF07510 Phobius swissprot:YFJM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFJM_ECOLI ProteinModelPortal P52128 http://www.proteinmodelportal.org/query/uniprot/P52128 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417118 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417118 RefSeq WP_000502050 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000502050 STRING 511145.b2629 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2629&targetmode=cogs UniProtKB YFJM_ECOLI http://www.uniprot.org/uniprot/YFJM_ECOLI UniProtKB-AC P52128 http://www.uniprot.org/uniprot/P52128 charge swissprot:YFJM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFJM_ECOLI eggNOG ENOG4107NPW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107NPW eggNOG ENOG410ZDU4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZDU4 epestfind swissprot:YFJM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFJM_ECOLI garnier swissprot:YFJM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFJM_ECOLI helixturnhelix swissprot:YFJM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFJM_ECOLI hmoment swissprot:YFJM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFJM_ECOLI iep swissprot:YFJM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFJM_ECOLI inforesidue swissprot:YFJM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFJM_ECOLI octanol swissprot:YFJM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFJM_ECOLI pepcoil swissprot:YFJM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFJM_ECOLI pepdigest swissprot:YFJM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFJM_ECOLI pepinfo swissprot:YFJM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFJM_ECOLI pepnet swissprot:YFJM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFJM_ECOLI pepstats swissprot:YFJM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFJM_ECOLI pepwheel swissprot:YFJM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFJM_ECOLI pepwindow swissprot:YFJM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFJM_ECOLI sigcleave swissprot:YFJM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFJM_ECOLI ## Database ID URL or Descriptions # BioGrid 4262804 9 # EcoGene EG13586 yahB # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; ISS:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # INTERACTION YAHB_ECOLI P11989 bglG; NbExp=3; IntAct=EBI-545731, EBI-545674; # IntAct P77700 6 # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR005119 LysR_subst-bd # InterPro IPR011991 WHTH_DNA-bd_dom # Organism YAHB_ECOLI Escherichia coli (strain K12) # PATRIC 32115761 VBIEscCol129921_0323 # PIR D64758 D64758 # PROSITE PS50931 HTH_LYSR # Pfam PF00126 HTH_1 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAHB_ECOLI Uncharacterized HTH-type transcriptional regulator YahB # RefSeq NP_414850 NC_000913.3 # RefSeq WP_001084394 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lysR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00253}. # SUPFAM SSF46785 SSF46785 # eggNOG ENOG4108NUU Bacteria # eggNOG ENOG410XQF9 LUCA BLAST swissprot:YAHB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAHB_ECOLI BioCyc ECOL316407:JW0308-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0308-MONOMER BioCyc EcoCyc:G6181-MONOMER http://biocyc.org/getid?id=EcoCyc:G6181-MONOMER DIP DIP-11254N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11254N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB3356 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3356 EcoGene EG13586 http://www.ecogene.org/geneInfo.php?eg_id=EG13586 EnsemblBacteria AAC73419 http://www.ensemblgenomes.org/id/AAC73419 EnsemblBacteria AAC73419 http://www.ensemblgenomes.org/id/AAC73419 EnsemblBacteria BAE76099 http://www.ensemblgenomes.org/id/BAE76099 EnsemblBacteria BAE76099 http://www.ensemblgenomes.org/id/BAE76099 EnsemblBacteria BAE76099 http://www.ensemblgenomes.org/id/BAE76099 EnsemblBacteria b0316 http://www.ensemblgenomes.org/id/b0316 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 945278 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945278 HOGENOM HOG000181312 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000181312&db=HOGENOM6 InParanoid P77700 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77700 IntAct P77700 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77700* InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW0308 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0308 KEGG_Gene eco:b0316 http://www.genome.jp/dbget-bin/www_bget?eco:b0316 MINT MINT-1294849 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1294849 OMA YFYRKAT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YFYRKAT PROSITE PS50931 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50931 PSORT swissprot:YAHB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAHB_ECOLI PSORT-B swissprot:YAHB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAHB_ECOLI PSORT2 swissprot:YAHB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAHB_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:YAHB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAHB_ECOLI PhylomeDB P77700 http://phylomedb.org/?seqid=P77700 ProteinModelPortal P77700 http://www.proteinmodelportal.org/query/uniprot/P77700 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414850 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414850 RefSeq WP_001084394 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001084394 SMR P77700 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77700 STRING 511145.b0316 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0316&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB YAHB_ECOLI http://www.uniprot.org/uniprot/YAHB_ECOLI UniProtKB-AC P77700 http://www.uniprot.org/uniprot/P77700 charge swissprot:YAHB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAHB_ECOLI eggNOG ENOG4108NUU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108NUU eggNOG ENOG410XQF9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQF9 epestfind swissprot:YAHB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAHB_ECOLI garnier swissprot:YAHB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAHB_ECOLI helixturnhelix swissprot:YAHB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAHB_ECOLI hmoment swissprot:YAHB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAHB_ECOLI iep swissprot:YAHB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAHB_ECOLI inforesidue swissprot:YAHB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAHB_ECOLI octanol swissprot:YAHB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAHB_ECOLI pepcoil swissprot:YAHB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAHB_ECOLI pepdigest swissprot:YAHB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAHB_ECOLI pepinfo swissprot:YAHB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAHB_ECOLI pepnet swissprot:YAHB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAHB_ECOLI pepstats swissprot:YAHB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAHB_ECOLI pepwheel swissprot:YAHB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAHB_ECOLI pepwindow swissprot:YAHB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAHB_ECOLI sigcleave swissprot:YAHB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAHB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260686 329 # DOMAIN OPGG_ECOLI Contains a large N-terminal domain that would serve as the catalytic core subunit, and a smaller C-terminal domain that would act to modulate this enzymatic activity. # EcoGene EG11885 mdoG # FUNCTION OPGG_ECOLI Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs). # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0003824 catalytic activity; IEA:InterPro. # GO_function GO:0030246 carbohydrate binding; IEA:InterPro. # GO_process GO:0006970 response to osmotic stress; IDA:EcoCyc. # GO_process GO:0051274 beta-glucan biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # Gene3D 2.60.40.10 -; 1. # Gene3D 2.70.98.10 -; 1. # HAMAP MF_01069 MdoG_OpgG # IntAct P33136 6 # InterPro IPR007444 Glucan_biosyn_MdoG_C # InterPro IPR011013 Gal_mutarotase_SF_dom # InterPro IPR013783 Ig-like_fold # InterPro IPR014438 Glucan_biosyn_MdoGD # InterPro IPR014718 GH-type_carb-bd # InterPro IPR014756 Ig_E-set # InterPro IPR023704 MdoG_OpgG # Organism OPGG_ECOLI Escherichia coli (strain K12) # PATHWAY OPGG_ECOLI Glycan metabolism; osmoregulated periplasmic glucan (OPG) biosynthesis. # PATRIC 32117335 VBIEscCol129921_1090 # PDB 1TXK X-ray; 2.50 A; A/B=23-511 # PIR S35417 S35417 # PIRSF PIRSF006281 MdoG # Pfam PF04349 MdoG # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName OPGG_ECOLI Glucans biosynthesis protein G # RefSeq NP_415566 NC_000913.3 # SIMILARITY Belongs to the OpgD/OpgG family. {ECO 0000305}. # SUBCELLULAR LOCATION OPGG_ECOLI Periplasm. # SUPFAM SSF74650 SSF74650 # SUPFAM SSF81296 SSF81296 # eggNOG COG3131 LUCA # eggNOG ENOG4105DJ9 Bacteria BLAST swissprot:OPGG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:OPGG_ECOLI BioCyc ECOL316407:JW1035-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1035-MONOMER BioCyc EcoCyc:EG11885-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11885-MONOMER COG COG3131 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3131 DIP DIP-10177N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10177N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1016/j.jmb.2004.07.004 http://dx.doi.org/10.1016/j.jmb.2004.07.004 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1993.tb01959.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb01959.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X64197 http://www.ebi.ac.uk/ena/data/view/X64197 EchoBASE EB1831 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1831 EcoGene EG11885 http://www.ecogene.org/geneInfo.php?eg_id=EG11885 EnsemblBacteria AAC74132 http://www.ensemblgenomes.org/id/AAC74132 EnsemblBacteria AAC74132 http://www.ensemblgenomes.org/id/AAC74132 EnsemblBacteria BAA35846 http://www.ensemblgenomes.org/id/BAA35846 EnsemblBacteria BAA35846 http://www.ensemblgenomes.org/id/BAA35846 EnsemblBacteria BAA35846 http://www.ensemblgenomes.org/id/BAA35846 EnsemblBacteria b1048 http://www.ensemblgenomes.org/id/b1048 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0003824 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003824 GO_function GO:0030246 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030246 GO_process GO:0006970 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006970 GO_process GO:0051274 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051274 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 2.60.40.10 http://www.cathdb.info/version/latest/superfamily/2.60.40.10 Gene3D 2.70.98.10 http://www.cathdb.info/version/latest/superfamily/2.70.98.10 GeneID 945005 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945005 HAMAP MF_01069 http://hamap.expasy.org/unirule/MF_01069 HOGENOM HOG000288261 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000288261&db=HOGENOM6 InParanoid P33136 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33136 IntAct P33136 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33136* InterPro IPR007444 http://www.ebi.ac.uk/interpro/entry/IPR007444 InterPro IPR011013 http://www.ebi.ac.uk/interpro/entry/IPR011013 InterPro IPR013783 http://www.ebi.ac.uk/interpro/entry/IPR013783 InterPro IPR014438 http://www.ebi.ac.uk/interpro/entry/IPR014438 InterPro IPR014718 http://www.ebi.ac.uk/interpro/entry/IPR014718 InterPro IPR014756 http://www.ebi.ac.uk/interpro/entry/IPR014756 InterPro IPR023704 http://www.ebi.ac.uk/interpro/entry/IPR023704 KEGG_Gene ecj:JW1035 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1035 KEGG_Gene eco:b1048 http://www.genome.jp/dbget-bin/www_bget?eco:b1048 KEGG_Orthology KO:K03670 http://www.genome.jp/dbget-bin/www_bget?KO:K03670 OMA KQDEIMT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KQDEIMT PDB 1TXK http://www.ebi.ac.uk/pdbe-srv/view/entry/1TXK PDBsum 1TXK http://www.ebi.ac.uk/pdbsum/1TXK PSORT swissprot:OPGG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:OPGG_ECOLI PSORT-B swissprot:OPGG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:OPGG_ECOLI PSORT2 swissprot:OPGG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:OPGG_ECOLI Pfam PF04349 http://pfam.xfam.org/family/PF04349 Phobius swissprot:OPGG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:OPGG_ECOLI PhylomeDB P33136 http://phylomedb.org/?seqid=P33136 ProteinModelPortal P33136 http://www.proteinmodelportal.org/query/uniprot/P33136 PubMed 15313617 http://www.ncbi.nlm.nih.gov/pubmed/15313617 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7934824 http://www.ncbi.nlm.nih.gov/pubmed/7934824 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_415566 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415566 SMR P33136 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33136 STRING 511145.b1048 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1048&targetmode=cogs STRING COG3131 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3131&targetmode=cogs SUPFAM SSF74650 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF74650 SUPFAM SSF81296 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81296 SWISS-2DPAGE P33136 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P33136 UniProtKB OPGG_ECOLI http://www.uniprot.org/uniprot/OPGG_ECOLI UniProtKB-AC P33136 http://www.uniprot.org/uniprot/P33136 charge swissprot:OPGG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:OPGG_ECOLI eggNOG COG3131 http://eggnogapi.embl.de/nog_data/html/tree/COG3131 eggNOG ENOG4105DJ9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DJ9 epestfind swissprot:OPGG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:OPGG_ECOLI garnier swissprot:OPGG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:OPGG_ECOLI helixturnhelix swissprot:OPGG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:OPGG_ECOLI hmoment swissprot:OPGG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:OPGG_ECOLI iep swissprot:OPGG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:OPGG_ECOLI inforesidue swissprot:OPGG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:OPGG_ECOLI octanol swissprot:OPGG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:OPGG_ECOLI pepcoil swissprot:OPGG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:OPGG_ECOLI pepdigest swissprot:OPGG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:OPGG_ECOLI pepinfo swissprot:OPGG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:OPGG_ECOLI pepnet swissprot:OPGG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:OPGG_ECOLI pepstats swissprot:OPGG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:OPGG_ECOLI pepwheel swissprot:OPGG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:OPGG_ECOLI pepwindow swissprot:OPGG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:OPGG_ECOLI sigcleave swissprot:OPGG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:OPGG_ECOLI ## Database ID URL or Descriptions # BioGrid 4263251 80 # EcoGene EG14296 ynaK # IntAct P76068 2 # InterPro IPR003115 ParB/Sulfiredoxin_dom # Organism YNAK_ECOLI Escherichia coli (strain K12) # PATRIC 32118006 VBIEscCol129921_1423 # PIR H64886 H64886 # Pfam PF02195 ParBc # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNAK_ECOLI Uncharacterized protein YnaK # RefSeq NP_415883 NC_000913.3 # RefSeq WP_001350510 NZ_CP014272.1 # SMART SM00470 ParB # SUPFAM SSF110849 SSF110849 # eggNOG COG1475 LUCA # eggNOG ENOG4108ES9 Bacteria BLAST swissprot:YNAK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNAK_ECOLI BioCyc ECOL316407:JW1359-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1359-MONOMER BioCyc EcoCyc:G6688-MONOMER http://biocyc.org/getid?id=EcoCyc:G6688-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4044 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4044 EcoGene EG14296 http://www.ecogene.org/geneInfo.php?eg_id=EG14296 EnsemblBacteria AAC74447 http://www.ensemblgenomes.org/id/AAC74447 EnsemblBacteria AAC74447 http://www.ensemblgenomes.org/id/AAC74447 EnsemblBacteria BAE76417 http://www.ensemblgenomes.org/id/BAE76417 EnsemblBacteria BAE76417 http://www.ensemblgenomes.org/id/BAE76417 EnsemblBacteria BAE76417 http://www.ensemblgenomes.org/id/BAE76417 EnsemblBacteria b1365 http://www.ensemblgenomes.org/id/b1365 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947417 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947417 IntAct P76068 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76068* InterPro IPR003115 http://www.ebi.ac.uk/interpro/entry/IPR003115 KEGG_Gene ecj:JW1359 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1359 KEGG_Gene eco:b1365 http://www.genome.jp/dbget-bin/www_bget?eco:b1365 OMA NCEPIVD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NCEPIVD PSORT swissprot:YNAK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNAK_ECOLI PSORT-B swissprot:YNAK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNAK_ECOLI PSORT2 swissprot:YNAK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNAK_ECOLI Pfam PF02195 http://pfam.xfam.org/family/PF02195 Phobius swissprot:YNAK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNAK_ECOLI PhylomeDB P76068 http://phylomedb.org/?seqid=P76068 ProteinModelPortal P76068 http://www.proteinmodelportal.org/query/uniprot/P76068 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415883 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415883 RefSeq WP_001350510 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001350510 SMART SM00470 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00470 SMR P76068 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76068 STRING 511145.b1365 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1365&targetmode=cogs SUPFAM SSF110849 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF110849 UniProtKB YNAK_ECOLI http://www.uniprot.org/uniprot/YNAK_ECOLI UniProtKB-AC P76068 http://www.uniprot.org/uniprot/P76068 charge swissprot:YNAK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNAK_ECOLI eggNOG COG1475 http://eggnogapi.embl.de/nog_data/html/tree/COG1475 eggNOG ENOG4108ES9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ES9 epestfind swissprot:YNAK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNAK_ECOLI garnier swissprot:YNAK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNAK_ECOLI helixturnhelix swissprot:YNAK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNAK_ECOLI hmoment swissprot:YNAK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNAK_ECOLI iep swissprot:YNAK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNAK_ECOLI inforesidue swissprot:YNAK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNAK_ECOLI octanol swissprot:YNAK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNAK_ECOLI pepcoil swissprot:YNAK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNAK_ECOLI pepdigest swissprot:YNAK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNAK_ECOLI pepinfo swissprot:YNAK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNAK_ECOLI pepnet swissprot:YNAK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNAK_ECOLI pepstats swissprot:YNAK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNAK_ECOLI pepwheel swissprot:YNAK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNAK_ECOLI pepwindow swissprot:YNAK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNAK_ECOLI sigcleave swissprot:YNAK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNAK_ECOLI ## Database ID URL or Descriptions # BioGrid 4259509 35 # CDD cd00403 Ribosomal_L1 # EcoGene EG10864 rplA # FUNCTION RL1_ECOLI One of the primary rRNA binding proteins, it binds very close to the 3'-end of the 23S rRNA. Forms part of the L1 stalk. It is often not seen in high-resolution crystal structures, but can be seen in cryo_EM and 3D reconstruction models. These indicate that the distal end of the stalk moves by approximately 20 angstroms (PubMed 12859903, PubMed 16272117). This stalk movement is thought to be coupled to movement of deacylated tRNA into and out of the E site, and thus to participate in tRNA translocation (PubMed 12859903, PubMed 16272117). Contacts the P and E site tRNAs. {ECO 0000269|PubMed 12859903, ECO 0000269|PubMed 16272117}. # FUNCTION RL1_ECOLI Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0022625 cytosolic large ribosomal subunit; IDA:EcoCyc. # GO_function GO:0000049 tRNA binding; IEA:UniProtKB-KW. # GO_function GO:0003723 RNA binding; IBA:GO_Central. # GO_function GO:0003735 structural constituent of ribosome; IEA:InterPro. # GO_function GO:0019843 rRNA binding; IEA:UniProtKB-HAMAP. # GO_process GO:0000470 maturation of LSU-rRNA; IBA:GO_Central. # GO_process GO:0006412 translation; IEA:UniProtKB-HAMAP. # GO_process GO:0045947 negative regulation of translational initiation; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_function GO:0019843 rRNA binding # GOslim_process GO:0006412 translation # GOslim_process GO:0008150 biological_process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.30.190.20 -; 2. # Gene3D 3.40.50.790 -; 1. # HAMAP MF_01318_B Ribosomal_L1_B # INTERACTION RL1_ECOLI P0A978 cspG; NbExp=2; IntAct=EBI-543771, EBI-547581; P0A8M3 thrS; NbExp=2; IntAct=EBI-543771, EBI-551254; # IntAct P0A7L0 125 # InterPro IPR002143 Ribosomal_L1 # InterPro IPR005878 Ribosom_L1_bac-type # InterPro IPR016094 Ribosomal_L1_2-a/b-sand # InterPro IPR016095 Ribosomal_L1_3-a/b-sand # InterPro IPR023673 Ribosomal_L1_CS # InterPro IPR023674 Ribosomal_L1-like # InterPro IPR028364 Ribosomal_L1/biogenesis # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 M00179 Ribosome, archaea # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=24598.9; Method=MALDI; Range=2-234; Evidence={ECO:0000269|PubMed 10094780}; # Organism RL1_ECOLI Escherichia coli (strain K12) # PATRIC 32123489 VBIEscCol129921_4097 # PDB 1EG0 EM; 11.50 A; N=1-229 # PDB 1ML5 EM; 14.00 A; c=2-229 # PDB 2RDO EM; 9.10 A; 9=2-234 # PDB 3J46 EM; 10.10 A; 5=1-234 # PDB 3J5S EM; 7.50 A; F=1-234 # PDB 3J8G EM; 5.00 A; 5=1-234 # PDB 3J9Z EM; 3.60 A; LC=1-234 # PDB 3JA1 EM; 3.60 A; LC=1-234 # PDB 3JCD EM; 3.70 A; 5=1-234 # PDB 3JCE EM; 3.20 A; 5=1-234 # PDB 487D EM; 7.50 A; H=29-201 # PDB 4CSU EM; 5.50 A; 5=1-234 # PDB 4U1U X-ray; 2.95 A; B5=2-229 # PDB 4U1V X-ray; 3.00 A; B5=2-229 # PDB 4U20 X-ray; 2.90 A; B5=2-229 # PDB 4U24 X-ray; 2.90 A; B5=2-229 # PDB 4U25 X-ray; 2.90 A; B5=2-229 # PDB 4U26 X-ray; 2.80 A; B5=2-229 # PDB 4U27 X-ray; 2.80 A; B5=2-229 # PDB 4V4V EM; 15.00 A; B2=6-227 # PDB 4V4W EM; 15.00 A; B2=6-227 # PDB 4V5H EM; 5.80 A; B5=1-234 # PDB 4V65 EM; 9.00 A; BZ=5-220 # PDB 4V66 EM; 9.00 A; BZ=5-220 # PDB 4V69 EM; 6.70 A; B5=1-234 # PDB 4V6K EM; 8.25 A; AC=1-234 # PDB 4V6L EM; 13.20 A; BC=1-234 # PDB 4V6M EM; 7.10 A; B5=1-234 # PDB 4V6N EM; 12.10 A; AC=1-234 # PDB 4V6O EM; 14.70 A; BC=1-234 # PDB 4V6P EM; 13.50 A; BC=1-234 # PDB 4V6Q EM; 11.50 A; BC=1-234 # PDB 4V6R EM; 11.50 A; BC=1-234 # PDB 4V6S EM; 13.10 A; AC=1-234 # PDB 4V6V EM; 9.80 A; BC=1-234 # PDB 4V6Y EM; 12.00 A; B5=1-234 # PDB 4V6Z EM; 12.00 A; B5=1-234 # PDB 4V70 EM; 17.00 A; B5=1-234 # PDB 4V71 EM; 20.00 A; B5=1-234 # PDB 4V72 EM; 13.00 A; B5=1-234 # PDB 4V73 EM; 15.00 A; B5=1-234 # PDB 4V74 EM; 17.00 A; B5=1-234 # PDB 4V75 EM; 12.00 A; B5=1-234 # PDB 4V76 EM; 17.00 A; B5=1-234 # PDB 4V77 EM; 17.00 A; B5=1-234 # PDB 4V78 EM; 20.00 A; B5=1-234 # PDB 4V79 EM; 15.00 A; B5=1-234 # PDB 4V7A EM; 9.00 A; B5=1-234 # PDB 4V7C EM; 7.60 A; BC=2-234 # PDB 4V7D EM; 7.60 A; AC=2-234 # PDB 4V7I EM; 9.60 A; A5=1-234 # PDB 4WOI X-ray; 3.00 A; B5=2-229 # PDB 5ADY EM; 4.50 A; 5=1-234 # PIR S12573 R5EC1 # PIRSF PIRSF002155 Ribosomal_L1 # PROSITE PS01199 RIBOSOMAL_L1 # Pfam PF00687 Ribosomal_L1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RL1_ECOLI 50S ribosomal protein L1 # RefSeq NP_418411 NC_000913.3 # RefSeq WP_001096684 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein L1P family. {ECO 0000305}. # SUBUNIT RL1_ECOLI Part of the 50S ribosomal subunit. Cross-links to the P and E site tRNAs. # SUPFAM SSF56808 SSF56808 # TIGRFAMs TIGR01169 rplA_bact # eggNOG COG0081 LUCA # eggNOG ENOG4105C64 Bacteria BLAST swissprot:RL1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RL1_ECOLI BioCyc ECOL316407:JW3947-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3947-MONOMER BioCyc EcoCyc:EG10864-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10864-MONOMER BioCyc MetaCyc:EG10864-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10864-MONOMER COG COG0081 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0081 DIP DIP-35746N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35746N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1006/jmbi.2000.3635 http://dx.doi.org/10.1006/jmbi.2000.3635 DOI 10.1016/0014-5793(78)80426-8 http://dx.doi.org/10.1016/0014-5793(78)80426-8 DOI 10.1016/S0092-8674(03)00476-8 http://dx.doi.org/10.1016/S0092-8674(03)00476-8 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nchembio.495 http://dx.doi.org/10.1038/nchembio.495 DOI 10.1073/pnas.76.4.1697 http://dx.doi.org/10.1073/pnas.76.4.1697 DOI 10.1093/nar/15.7.3085 http://dx.doi.org/10.1093/nar/15.7.3085 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1093/nar/23.22.4635 http://dx.doi.org/10.1093/nar/23.22.4635 DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pbio.1001866 http://dx.doi.org/10.1371/journal.pbio.1001866 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00339 http://www.ebi.ac.uk/ena/data/view/V00339 EchoBASE EB0857 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0857 EcoGene EG10864 http://www.ecogene.org/geneInfo.php?eg_id=EG10864 EnsemblBacteria AAC76958 http://www.ensemblgenomes.org/id/AAC76958 EnsemblBacteria AAC76958 http://www.ensemblgenomes.org/id/AAC76958 EnsemblBacteria BAE77336 http://www.ensemblgenomes.org/id/BAE77336 EnsemblBacteria BAE77336 http://www.ensemblgenomes.org/id/BAE77336 EnsemblBacteria BAE77336 http://www.ensemblgenomes.org/id/BAE77336 EnsemblBacteria b3984 http://www.ensemblgenomes.org/id/b3984 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0022625 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022625 GO_function GO:0000049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000049 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GO_process GO:0000470 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000470 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GO_process GO:0045947 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045947 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.30.190.20 http://www.cathdb.info/version/latest/superfamily/3.30.190.20 Gene3D 3.40.50.790 http://www.cathdb.info/version/latest/superfamily/3.40.50.790 GeneID 948483 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948483 HAMAP MF_01318_B http://hamap.expasy.org/unirule/MF_01318_B HOGENOM HOG000207015 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000207015&db=HOGENOM6 InParanoid P0A7L0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7L0 IntAct P0A7L0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7L0* InterPro IPR002143 http://www.ebi.ac.uk/interpro/entry/IPR002143 InterPro IPR005878 http://www.ebi.ac.uk/interpro/entry/IPR005878 InterPro IPR016094 http://www.ebi.ac.uk/interpro/entry/IPR016094 InterPro IPR016095 http://www.ebi.ac.uk/interpro/entry/IPR016095 InterPro IPR023673 http://www.ebi.ac.uk/interpro/entry/IPR023673 InterPro IPR023674 http://www.ebi.ac.uk/interpro/entry/IPR023674 InterPro IPR028364 http://www.ebi.ac.uk/interpro/entry/IPR028364 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW3947 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3947 KEGG_Gene eco:b3984 http://www.genome.jp/dbget-bin/www_bget?eco:b3984 KEGG_Orthology KO:K02863 http://www.genome.jp/dbget-bin/www_bget?KO:K02863 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 MINT MINT-1268287 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1268287 OMA KIQNDKV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KIQNDKV PDB 1EG0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1EG0 PDB 1ML5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ML5 PDB 2RDO http://www.ebi.ac.uk/pdbe-srv/view/entry/2RDO PDB 3J46 http://www.ebi.ac.uk/pdbe-srv/view/entry/3J46 PDB 3J5S http://www.ebi.ac.uk/pdbe-srv/view/entry/3J5S PDB 3J8G http://www.ebi.ac.uk/pdbe-srv/view/entry/3J8G PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 487D http://www.ebi.ac.uk/pdbe-srv/view/entry/487D PDB 4CSU http://www.ebi.ac.uk/pdbe-srv/view/entry/4CSU PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 5ADY http://www.ebi.ac.uk/pdbe-srv/view/entry/5ADY PDBsum 1EG0 http://www.ebi.ac.uk/pdbsum/1EG0 PDBsum 1ML5 http://www.ebi.ac.uk/pdbsum/1ML5 PDBsum 2RDO http://www.ebi.ac.uk/pdbsum/2RDO PDBsum 3J46 http://www.ebi.ac.uk/pdbsum/3J46 PDBsum 3J5S http://www.ebi.ac.uk/pdbsum/3J5S PDBsum 3J8G http://www.ebi.ac.uk/pdbsum/3J8G PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 487D http://www.ebi.ac.uk/pdbsum/487D PDBsum 4CSU http://www.ebi.ac.uk/pdbsum/4CSU PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 5ADY http://www.ebi.ac.uk/pdbsum/5ADY PROSITE PS01199 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01199 PSORT swissprot:RL1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RL1_ECOLI PSORT-B swissprot:RL1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RL1_ECOLI PSORT2 swissprot:RL1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RL1_ECOLI Pfam PF00687 http://pfam.xfam.org/family/PF00687 Phobius swissprot:RL1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RL1_ECOLI PhylomeDB P0A7L0 http://phylomedb.org/?seqid=P0A7L0 ProteinModelPortal P0A7L0 http://www.proteinmodelportal.org/query/uniprot/P0A7L0 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 10756104 http://www.ncbi.nlm.nih.gov/pubmed/10756104 PubMed 12859903 http://www.ncbi.nlm.nih.gov/pubmed/12859903 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21151122 http://www.ncbi.nlm.nih.gov/pubmed/21151122 PubMed 24844575 http://www.ncbi.nlm.nih.gov/pubmed/24844575 PubMed 3104883 http://www.ncbi.nlm.nih.gov/pubmed/3104883 PubMed 3298242 http://www.ncbi.nlm.nih.gov/pubmed/3298242 PubMed 365581 http://www.ncbi.nlm.nih.gov/pubmed/365581 PubMed 377281 http://www.ncbi.nlm.nih.gov/pubmed/377281 PubMed 7556101 http://www.ncbi.nlm.nih.gov/pubmed/7556101 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 8524654 http://www.ncbi.nlm.nih.gov/pubmed/8524654 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_418411 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418411 RefSeq WP_001096684 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001096684 SMR P0A7L0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7L0 STRING 511145.b3984 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3984&targetmode=cogs STRING COG0081 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0081&targetmode=cogs SUPFAM SSF56808 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56808 SWISS-2DPAGE P0A7L0 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A7L0 TIGRFAMs TIGR01169 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01169 UniProtKB RL1_ECOLI http://www.uniprot.org/uniprot/RL1_ECOLI UniProtKB-AC P0A7L0 http://www.uniprot.org/uniprot/P0A7L0 charge swissprot:RL1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RL1_ECOLI eggNOG COG0081 http://eggnogapi.embl.de/nog_data/html/tree/COG0081 eggNOG ENOG4105C64 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C64 epestfind swissprot:RL1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RL1_ECOLI garnier swissprot:RL1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RL1_ECOLI helixturnhelix swissprot:RL1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RL1_ECOLI hmoment swissprot:RL1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RL1_ECOLI iep swissprot:RL1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RL1_ECOLI inforesidue swissprot:RL1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RL1_ECOLI octanol swissprot:RL1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RL1_ECOLI pepcoil swissprot:RL1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RL1_ECOLI pepdigest swissprot:RL1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RL1_ECOLI pepinfo swissprot:RL1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RL1_ECOLI pepnet swissprot:RL1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RL1_ECOLI pepstats swissprot:RL1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RL1_ECOLI pepwheel swissprot:RL1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RL1_ECOLI pepwindow swissprot:RL1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RL1_ECOLI sigcleave swissprot:RL1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RL1_ECOLI ## Database ID URL or Descriptions # BioGrid 4261147 8 # CATALYTIC ACTIVITY ATP + H(2)O + molybdate(Out) = ADP + phosphate + molybdate(In). {ECO:0000255|HAMAP-Rule MF_01705}. # EcoGene EG10152 modC # FUNCTION MODC_ECOLI Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system. {ECO 0000255|HAMAP-Rule MF_01705}. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IEA:UniProtKB-HAMAP. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0015412 ATPase-coupled molybdate transmembrane transporter activity; IEA:UniProtKB-HAMAP. # GO_function GO:0030151 molybdenum ion binding; IEA:InterPro. # GO_function GO:0042888 molybdenum ion transmembrane transporter activity; IEA:InterPro. # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.300 -; 1. # IntAct P09833 2 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR004606 Mo-pterin-bd # InterPro IPR005116 Transp-assoc_OB_typ1 # InterPro IPR008995 Mo/tungstate-bd_C_term_dom # InterPro IPR011868 ModC_ABC_ATP-bd # InterPro IPR015852 ABC_transpr_ModC # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00189 Molybdate transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism MODC_ECOLI Escherichia coli (strain K12) # PATRIC 32116731 VBIEscCol129921_0791 # PIR E64812 BVECHD # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # PROSITE PS51241 MODC # Pfam PF00005 ABC_tran # Pfam PF03459 TOBE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Molybdenum import ATP-binding protein ModC {ECO:0000255|HAMAP-Rule MF_01705} # RefSeq NP_415286 NC_000913.3 # RefSeq WP_000891692 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. Molybdate importer (TC 3.A.1.8) family. {ECO:0000255|HAMAP-Rule MF_01705}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|HAMAP- Rule MF_01705}. # SMART SM00382 AAA # SUBCELLULAR LOCATION MODC_ECOLI Cell inner membrane; Peripheral membrane protein. # SUBUNIT The complex is composed of two ATP-binding proteins (ModC), two transmembrane proteins (ModB) and a solute-binding protein (ModA). {ECO:0000255|HAMAP-Rule MF_01705}. # SUPFAM SSF50331 SSF50331 # SUPFAM SSF52540 SSF52540 # TCDB 3.A.1.8 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR00638 Mop # TIGRFAMs TIGR02142 modC_ABC # eggNOG COG4148 LUCA # eggNOG ENOG4105CGB Bacteria BLAST swissprot:MODC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MODC_ECOLI BioCyc ECOL316407:JW0748-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0748-MONOMER BioCyc EcoCyc:MODC-MONOMER http://biocyc.org/getid?id=EcoCyc:MODC-MONOMER BioCyc MetaCyc:MODC-MONOMER http://biocyc.org/getid?id=MetaCyc:MODC-MONOMER COG COG1118 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1118 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.3.29 {ECO:0000255|HAMAP-Rule:MF_01705} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.29 {ECO:0000255|HAMAP-Rule:MF_01705} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L34009 http://www.ebi.ac.uk/ena/data/view/L34009 EMBL M16182 http://www.ebi.ac.uk/ena/data/view/M16182 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U07867 http://www.ebi.ac.uk/ena/data/view/U07867 EMBL U27192 http://www.ebi.ac.uk/ena/data/view/U27192 ENZYME 3.6.3.29 {ECO:0000255|HAMAP-Rule:MF_01705} http://enzyme.expasy.org/EC/3.6.3.29 {ECO:0000255|HAMAP-Rule:MF_01705} EchoBASE EB0150 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0150 EcoGene EG10152 http://www.ecogene.org/geneInfo.php?eg_id=EG10152 EnsemblBacteria AAC73852 http://www.ensemblgenomes.org/id/AAC73852 EnsemblBacteria AAC73852 http://www.ensemblgenomes.org/id/AAC73852 EnsemblBacteria BAA35429 http://www.ensemblgenomes.org/id/BAA35429 EnsemblBacteria BAA35429 http://www.ensemblgenomes.org/id/BAA35429 EnsemblBacteria BAA35429 http://www.ensemblgenomes.org/id/BAA35429 EnsemblBacteria b0765 http://www.ensemblgenomes.org/id/b0765 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0015412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015412 GO_function GO:0030151 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030151 GO_function GO:0042888 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042888 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945362 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945362 InParanoid P09833 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P09833 IntAct P09833 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P09833* IntEnz 3.6.3.29 {ECO:0000255|HAMAP-Rule:MF_01705} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.29 {ECO:0000255|HAMAP-Rule:MF_01705} InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR004606 http://www.ebi.ac.uk/interpro/entry/IPR004606 InterPro IPR005116 http://www.ebi.ac.uk/interpro/entry/IPR005116 InterPro IPR008995 http://www.ebi.ac.uk/interpro/entry/IPR008995 InterPro IPR011868 http://www.ebi.ac.uk/interpro/entry/IPR011868 InterPro IPR015852 http://www.ebi.ac.uk/interpro/entry/IPR015852 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0748 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0748 KEGG_Gene eco:b0765 http://www.genome.jp/dbget-bin/www_bget?eco:b0765 KEGG_Orthology KO:K02017 http://www.genome.jp/dbget-bin/www_bget?KO:K02017 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA MLELDFS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MLELDFS PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PROSITE PS51241 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51241 PSORT swissprot:MODC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MODC_ECOLI PSORT-B swissprot:MODC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MODC_ECOLI PSORT2 swissprot:MODC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MODC_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Pfam PF03459 http://pfam.xfam.org/family/PF03459 Phobius swissprot:MODC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MODC_ECOLI PhylomeDB P09833 http://phylomedb.org/?seqid=P09833 ProteinModelPortal P09833 http://www.proteinmodelportal.org/query/uniprot/P09833 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3553151 http://www.ncbi.nlm.nih.gov/pubmed/3553151 PubMed 7665460 http://www.ncbi.nlm.nih.gov/pubmed/7665460 PubMed 8564363 http://www.ncbi.nlm.nih.gov/pubmed/8564363 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415286 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415286 RefSeq WP_000891692 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000891692 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P09833 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P09833 STRING 511145.b0765 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0765&targetmode=cogs STRING COG1118 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1118&targetmode=cogs SUPFAM SSF50331 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50331 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.8 http://www.tcdb.org/search/result.php?tc=3.A.1.8 TIGRFAMs TIGR00638 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00638 TIGRFAMs TIGR02142 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02142 UniProtKB MODC_ECOLI http://www.uniprot.org/uniprot/MODC_ECOLI UniProtKB-AC P09833 http://www.uniprot.org/uniprot/P09833 charge swissprot:MODC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MODC_ECOLI eggNOG COG4148 http://eggnogapi.embl.de/nog_data/html/tree/COG4148 eggNOG ENOG4105CGB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CGB epestfind swissprot:MODC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MODC_ECOLI garnier swissprot:MODC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MODC_ECOLI helixturnhelix swissprot:MODC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MODC_ECOLI hmoment swissprot:MODC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MODC_ECOLI iep swissprot:MODC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MODC_ECOLI inforesidue swissprot:MODC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MODC_ECOLI octanol swissprot:MODC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MODC_ECOLI pepcoil swissprot:MODC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MODC_ECOLI pepdigest swissprot:MODC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MODC_ECOLI pepinfo swissprot:MODC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MODC_ECOLI pepnet swissprot:MODC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MODC_ECOLI pepstats swissprot:MODC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MODC_ECOLI pepwheel swissprot:MODC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MODC_ECOLI pepwindow swissprot:MODC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MODC_ECOLI sigcleave swissprot:MODC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MODC_ECOLI ## Database ID URL or Descriptions # BioGrid 4260435 265 # DISRUPTION PHENOTYPE Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain. {ECO:0000269|PubMed 20345943}. # EcoGene EG11988 yehB # FUNCTION YEHB_ECOLI Part of the yehABCD fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Probably involved in the export and assembly of fimbrial subunits across the outer membrane. {ECO 0000269|PubMed 20345943}. # GO_component GO:0009279 cell outer membrane; IBA:GO_Central. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015473 fimbrial usher porin activity; IBA:GO_Central. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0009297 pilus assembly; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006950 response to stress # GOslim_process GO:0022607 cellular component assembly # INDUCTION Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression. {ECO:0000269|PubMed 20345943}. # IntAct P33341 2 # InterPro IPR000015 Fimb_usher # InterPro IPR018030 Fimbrial_membr_usher_CS # InterPro IPR025885 PapC_N # InterPro IPR025949 PapC-like_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02000 Transporters # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko05133 Pertussis # MISCELLANEOUS The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed. {ECO:0000305|PubMed 20345943}. # Organism YEHB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30451 PTHR30451 # PATRIC 32119551 VBIEscCol129921_2186 # PIR D64978 D64978 # PROSITE PS01151 FIMBRIAL_USHER # Pfam PF00577 Usher # Pfam PF13953 PapC_C # Pfam PF13954 PapC_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEHB_ECOLI Outer membrane usher protein YehB # RefSeq NP_416612 NC_000913.3 # RefSeq WP_000945454 NZ_LN832404.1 # SIMILARITY Belongs to the fimbrial export usher family. {ECO 0000305}. # SUBCELLULAR LOCATION YEHB_ECOLI Cell outer membrane {ECO 0000250}; Multi- pass membrane protein {ECO 0000250}. # TCDB 1.B.11.3.11 the outer membrane fimbrial usher porin (fup) family # eggNOG COG3188 LUCA # eggNOG ENOG4105CW0 Bacteria BLAST swissprot:YEHB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEHB_ECOLI BioCyc ECOL316407:JW2096-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2096-MONOMER BioCyc EcoCyc:EG11988-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11988-MONOMER COG COG3188 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3188 DIP DIP-11896N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11896N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1111/j.1462-2920.2010.02202.x http://dx.doi.org/10.1111/j.1462-2920.2010.02202.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1931 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1931 EcoGene EG11988 http://www.ecogene.org/geneInfo.php?eg_id=EG11988 EnsemblBacteria AAC75170 http://www.ensemblgenomes.org/id/AAC75170 EnsemblBacteria AAC75170 http://www.ensemblgenomes.org/id/AAC75170 EnsemblBacteria BAA15975 http://www.ensemblgenomes.org/id/BAA15975 EnsemblBacteria BAA15975 http://www.ensemblgenomes.org/id/BAA15975 EnsemblBacteria BAA15975 http://www.ensemblgenomes.org/id/BAA15975 EnsemblBacteria b2109 http://www.ensemblgenomes.org/id/b2109 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015473 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015473 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0009297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009297 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GeneID 946617 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946617 HOGENOM HOG000111415 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000111415&db=HOGENOM6 InParanoid P33341 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33341 IntAct P33341 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33341* InterPro IPR000015 http://www.ebi.ac.uk/interpro/entry/IPR000015 InterPro IPR018030 http://www.ebi.ac.uk/interpro/entry/IPR018030 InterPro IPR025885 http://www.ebi.ac.uk/interpro/entry/IPR025885 InterPro IPR025949 http://www.ebi.ac.uk/interpro/entry/IPR025949 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW2096 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2096 KEGG_Gene eco:b2109 http://www.genome.jp/dbget-bin/www_bget?eco:b2109 KEGG_Orthology KO:K07347 http://www.genome.jp/dbget-bin/www_bget?KO:K07347 KEGG_Pathway ko05133 http://www.genome.jp/kegg-bin/show_pathway?ko05133 MINT MINT-1263138 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1263138 OMA GINTDNF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GINTDNF PANTHER PTHR30451 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30451 PROSITE PS01151 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01151 PSORT swissprot:YEHB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEHB_ECOLI PSORT-B swissprot:YEHB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEHB_ECOLI PSORT2 swissprot:YEHB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEHB_ECOLI Pfam PF00577 http://pfam.xfam.org/family/PF00577 Pfam PF13953 http://pfam.xfam.org/family/PF13953 Pfam PF13954 http://pfam.xfam.org/family/PF13954 Phobius swissprot:YEHB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEHB_ECOLI PhylomeDB P33341 http://phylomedb.org/?seqid=P33341 ProteinModelPortal P33341 http://www.proteinmodelportal.org/query/uniprot/P33341 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20345943 http://www.ncbi.nlm.nih.gov/pubmed/20345943 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416612 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416612 RefSeq WP_000945454 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000945454 SMR P33341 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33341 STRING 511145.b2109 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2109&targetmode=cogs STRING COG3188 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3188&targetmode=cogs TCDB 1.B.11.3.11 http://www.tcdb.org/search/result.php?tc=1.B.11.3.11 UniProtKB YEHB_ECOLI http://www.uniprot.org/uniprot/YEHB_ECOLI UniProtKB-AC P33341 http://www.uniprot.org/uniprot/P33341 charge swissprot:YEHB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEHB_ECOLI eggNOG COG3188 http://eggnogapi.embl.de/nog_data/html/tree/COG3188 eggNOG ENOG4105CW0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CW0 epestfind swissprot:YEHB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEHB_ECOLI garnier swissprot:YEHB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEHB_ECOLI helixturnhelix swissprot:YEHB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEHB_ECOLI hmoment swissprot:YEHB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEHB_ECOLI iep swissprot:YEHB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEHB_ECOLI inforesidue swissprot:YEHB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEHB_ECOLI octanol swissprot:YEHB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEHB_ECOLI pepcoil swissprot:YEHB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEHB_ECOLI pepdigest swissprot:YEHB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEHB_ECOLI pepinfo swissprot:YEHB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEHB_ECOLI pepnet swissprot:YEHB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEHB_ECOLI pepstats swissprot:YEHB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEHB_ECOLI pepwheel swissprot:YEHB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEHB_ECOLI pepwindow swissprot:YEHB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEHB_ECOLI sigcleave swissprot:YEHB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEHB_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES ADEP_ECOLI Kinetic parameters KM=1.0 uM for adenine {ECO 0000269|PubMed 24214977}; Vmax=1.7 nmol/min/mg enzyme {ECO 0000269|PubMed 24214977}; # BioGrid 4262172 244 # ENZYME REGULATION Internal adenine may inhibit transport. {ECO:0000269|PubMed 8165228}. # EcoGene EG11724 adeP # FUNCTION ADEP_ECOLI High-affinity transporter for adenine. {ECO 0000269|PubMed 24214977, ECO 0000269|PubMed 6198438, ECO 0000269|PubMed 8165228}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function ADEP_ECOLI GO 0015295 solute proton symporter activity; IDA EcoCyc. # GO_function GO:0015207 adenine transmembrane transporter activity; IDA:EcoCyc. # GO_process GO:0015853 adenine transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR006043 Xant/urac/vitC # InterPro IPR026033 Pur_Permease_PbuG-like # InterPro IPR029940 AzgA # KEGG_Brite ko02000 Transporters # Organism ADEP_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11119 PTHR11119 # PANTHER PTHR11119:SF9 PTHR11119:SF9 # PATRIC 32122923 VBIEscCol129921_3837 # PIR C65174 C65174 # PIRSF PIRSF005353 PbuG # Pfam PF00860 Xan_ur_permease # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ADEP_ECOLI Adenine permease AdeP # RefSeq NP_418170 NC_000913.3 # RefSeq WP_000019348 NZ_LN832404.1 # SIMILARITY Belongs to the xanthine/uracil permease family. AzgA purine transporter (TC 2.A.1.40) subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION ADEP_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 24214977}; Multi- pass membrane protein {ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 24214977}. # TCDB 2.A.40.7:the nucleobase/ascorbate transporter (nat) or nucleobase cation symporter-2 (ncs2) family # eggNOG COG2252 LUCA # eggNOG ENOG4105C7N Bacteria BLAST swissprot:ADEP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ADEP_ECOLI BioCyc ECOL316407:JW3692-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3692-MONOMER BioCyc EcoCyc:EG11724-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11724-MONOMER BioCyc MetaCyc:EG11724-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11724-MONOMER COG COG2252 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2252 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M113.523340 http://dx.doi.org/10.1074/jbc.M113.523340 DOI 10.1098/rspb.1994.0022 http://dx.doi.org/10.1098/rspb.1994.0022 DOI 10.1099/00221287-129-11-3505 http://dx.doi.org/10.1099/00221287-129-11-3505 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1675 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1675 EcoGene EG11724 http://www.ecogene.org/geneInfo.php?eg_id=EG11724 EnsemblBacteria AAC76737 http://www.ensemblgenomes.org/id/AAC76737 EnsemblBacteria AAC76737 http://www.ensemblgenomes.org/id/AAC76737 EnsemblBacteria BAE77574 http://www.ensemblgenomes.org/id/BAE77574 EnsemblBacteria BAE77574 http://www.ensemblgenomes.org/id/BAE77574 EnsemblBacteria BAE77574 http://www.ensemblgenomes.org/id/BAE77574 EnsemblBacteria b3714 http://www.ensemblgenomes.org/id/b3714 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015207 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015207 GO_function GO:0015295 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015295 GO_process GO:0015853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015853 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948224 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948224 HOGENOM HOG000244362 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000244362&db=HOGENOM6 InParanoid P31466 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31466 InterPro IPR006043 http://www.ebi.ac.uk/interpro/entry/IPR006043 InterPro IPR026033 http://www.ebi.ac.uk/interpro/entry/IPR026033 InterPro IPR029940 http://www.ebi.ac.uk/interpro/entry/IPR029940 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3692 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3692 KEGG_Gene eco:b3714 http://www.genome.jp/dbget-bin/www_bget?eco:b3714 KEGG_Orthology KO:K06901 http://www.genome.jp/dbget-bin/www_bget?KO:K06901 OMA MVDFFDT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MVDFFDT PANTHER PTHR11119 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11119 PANTHER PTHR11119:SF9 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11119:SF9 PSORT swissprot:ADEP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ADEP_ECOLI PSORT-B swissprot:ADEP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ADEP_ECOLI PSORT2 swissprot:ADEP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ADEP_ECOLI Pfam PF00860 http://pfam.xfam.org/family/PF00860 Phobius swissprot:ADEP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ADEP_ECOLI PhylomeDB P31466 http://phylomedb.org/?seqid=P31466 ProteinModelPortal P31466 http://www.proteinmodelportal.org/query/uniprot/P31466 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 24214977 http://www.ncbi.nlm.nih.gov/pubmed/24214977 PubMed 6198438 http://www.ncbi.nlm.nih.gov/pubmed/6198438 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 8165228 http://www.ncbi.nlm.nih.gov/pubmed/8165228 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418170 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418170 RefSeq WP_000019348 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000019348 STRING 511145.b3714 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3714&targetmode=cogs STRING COG2252 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2252&targetmode=cogs TCDB 2.A.40.7 http://www.tcdb.org/search/result.php?tc=2.A.40.7 UniProtKB ADEP_ECOLI http://www.uniprot.org/uniprot/ADEP_ECOLI UniProtKB-AC P31466 http://www.uniprot.org/uniprot/P31466 charge swissprot:ADEP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ADEP_ECOLI eggNOG COG2252 http://eggnogapi.embl.de/nog_data/html/tree/COG2252 eggNOG ENOG4105C7N http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C7N epestfind swissprot:ADEP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ADEP_ECOLI garnier swissprot:ADEP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ADEP_ECOLI helixturnhelix swissprot:ADEP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ADEP_ECOLI hmoment swissprot:ADEP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ADEP_ECOLI iep swissprot:ADEP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ADEP_ECOLI inforesidue swissprot:ADEP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ADEP_ECOLI octanol swissprot:ADEP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ADEP_ECOLI pepcoil swissprot:ADEP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ADEP_ECOLI pepdigest swissprot:ADEP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ADEP_ECOLI pepinfo swissprot:ADEP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ADEP_ECOLI pepnet swissprot:ADEP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ADEP_ECOLI pepstats swissprot:ADEP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ADEP_ECOLI pepwheel swissprot:ADEP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ADEP_ECOLI pepwindow swissprot:ADEP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ADEP_ECOLI sigcleave swissprot:ADEP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ADEP_ECOLI ## Database ID URL or Descriptions # AltName HIUH_ECOLI Transthyretin-like protein # AltName HIUH_ECOLI Transthyretin-related protein # BRENDA 3.5.2.17 2026 # BioGrid 4260382 3 # CATALYTIC ACTIVITY 5-hydroxyisourate + H(2)O = 5-hydroxy-2-oxo-4- ureido-2,5-dihydro-1H-imidazole-5-carboxylate. {ECO:0000269|PubMed 16098976}. # EcoGene EG14046 hiuH # FUNCTION HIUH_ECOLI Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU). # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_function GO:0033971 hydroxyisourate hydrolase activity; IEA:UniProtKB-EC. # GO_process GO:0006144 purine nucleobase metabolic process; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 2.60.40.180 -; 1. # InterPro IPR000895 Transthyretin/HIU_hydrolase # InterPro IPR014306 Hydroxyisourate_hydrolase # InterPro IPR023416 Transthyretin/HIU_hydrolase_SF # InterPro IPR023418 Thyroxine_BS # InterPro IPR023419 Transthyretin_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # MASS SPECTROMETRY Mass=13013; Method=Electrospray; Range=24-137; Evidence={ECO:0000269|PubMed 12542701}; # MISCELLANEOUS HIUH_ECOLI Although some crystallographic structures were found to contain zinc, the purified protein does not contain bound metal ions, and does not require zinc or other metal ions for enzyme activity. # MISCELLANEOUS HIUH_ECOLI Despite its homology to transthyretins, is not able to bind to the thyroid hormones thyroxine (T4) and triiodothyronine (T3). # MISCELLANEOUS HIUH_ECOLI HIU hydrolysis also occurs spontaneously, but more slowly. # Organism HIUH_ECOLI Escherichia coli (strain K12) # PATRIC 32119271 VBIEscCol129921_2050 # PDB 2G2N X-ray; 1.65 A; A/B/C/D=24-137 # PDB 2G2P X-ray; 2.10 A; A/B/C/D=24-137 # PDB 2IGL X-ray; 1.80 A; A/B/C/D=24-137 # PIR F64961 F64961 # PRINTS PR00189 TRNSTHYRETIN # PROSITE PS00768 TRANSTHYRETIN_1 # PROSITE PS00769 TRANSTHYRETIN_2 # Pfam PF00576 Transthyretin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HIUH_ECOLI 5-hydroxyisourate hydrolase # RefSeq NP_416479 NC_000913.3 # RefSeq WP_000920120 NZ_LN832404.1 # SIMILARITY Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily. {ECO 0000305}. # SMART SM00095 TR_THY # SUBCELLULAR LOCATION HIUH_ECOLI Periplasm {ECO 0000269|Ref.3}. # SUBUNIT HIUH_ECOLI Homotetramer. {ECO 0000269|PubMed 12542701, ECO 0000269|PubMed 16723258}. # SUPFAM SSF49472 SSF49472 # TIGRFAMs TIGR02962 hdxy_isourate # eggNOG COG2351 LUCA # eggNOG ENOG4105VT2 Bacteria BLAST swissprot:HIUH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HIUH_ECOLI BioCyc ECOL316407:JW1953-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1953-MONOMER BioCyc EcoCyc:G7058-MONOMER http://biocyc.org/getid?id=EcoCyc:G7058-MONOMER BioCyc MetaCyc:G7058-MONOMER http://biocyc.org/getid?id=MetaCyc:G7058-MONOMER COG COG2351 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2351 DIP DIP-11854N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11854N DOI 10.1016/j.febslet.2005.07.056 http://dx.doi.org/10.1016/j.febslet.2005.07.056 DOI 10.1016/j.jsb.2006.04.002 http://dx.doi.org/10.1016/j.jsb.2006.04.002 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1432-1033.2003.03408.x http://dx.doi.org/10.1046/j.1432-1033.2003.03408.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.5.2.17 http://www.genome.jp/dbget-bin/www_bget?EC:3.5.2.17 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.5.2.17 http://enzyme.expasy.org/EC/3.5.2.17 EchoBASE EB3799 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3799 EcoGene EG14046 http://www.ecogene.org/geneInfo.php?eg_id=EG14046 EnsemblBacteria AAC75036 http://www.ensemblgenomes.org/id/AAC75036 EnsemblBacteria AAC75036 http://www.ensemblgenomes.org/id/AAC75036 EnsemblBacteria BAE76558 http://www.ensemblgenomes.org/id/BAE76558 EnsemblBacteria BAE76558 http://www.ensemblgenomes.org/id/BAE76558 EnsemblBacteria BAE76558 http://www.ensemblgenomes.org/id/BAE76558 EnsemblBacteria b1970 http://www.ensemblgenomes.org/id/b1970 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0033971 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033971 GO_process GO:0006144 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006144 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 2.60.40.180 http://www.cathdb.info/version/latest/superfamily/2.60.40.180 GeneID 946485 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946485 HOGENOM HOG000251776 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000251776&db=HOGENOM6 InParanoid P76341 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76341 IntAct P76341 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76341* IntEnz 3.5.2.17 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.2.17 InterPro IPR000895 http://www.ebi.ac.uk/interpro/entry/IPR000895 InterPro IPR014306 http://www.ebi.ac.uk/interpro/entry/IPR014306 InterPro IPR023416 http://www.ebi.ac.uk/interpro/entry/IPR023416 InterPro IPR023418 http://www.ebi.ac.uk/interpro/entry/IPR023418 InterPro IPR023419 http://www.ebi.ac.uk/interpro/entry/IPR023419 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1953 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1953 KEGG_Gene eco:b1970 http://www.genome.jp/dbget-bin/www_bget?eco:b1970 KEGG_Orthology KO:K07127 http://www.genome.jp/dbget-bin/www_bget?KO:K07127 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Reaction rn:R06601 http://www.genome.jp/dbget-bin/www_bget?rn:R06601 OMA PWAYSTY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PWAYSTY PDB 2G2N http://www.ebi.ac.uk/pdbe-srv/view/entry/2G2N PDB 2G2P http://www.ebi.ac.uk/pdbe-srv/view/entry/2G2P PDB 2IGL http://www.ebi.ac.uk/pdbe-srv/view/entry/2IGL PDBsum 2G2N http://www.ebi.ac.uk/pdbsum/2G2N PDBsum 2G2P http://www.ebi.ac.uk/pdbsum/2G2P PDBsum 2IGL http://www.ebi.ac.uk/pdbsum/2IGL PRINTS PR00189 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00189 PROSITE PS00768 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00768 PROSITE PS00769 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00769 PSORT swissprot:HIUH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HIUH_ECOLI PSORT-B swissprot:HIUH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HIUH_ECOLI PSORT2 swissprot:HIUH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HIUH_ECOLI Pfam PF00576 http://pfam.xfam.org/family/PF00576 Phobius swissprot:HIUH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HIUH_ECOLI PhylomeDB P76341 http://phylomedb.org/?seqid=P76341 ProteinModelPortal P76341 http://www.proteinmodelportal.org/query/uniprot/P76341 PubMed 12542701 http://www.ncbi.nlm.nih.gov/pubmed/12542701 PubMed 16098976 http://www.ncbi.nlm.nih.gov/pubmed/16098976 PubMed 16723258 http://www.ncbi.nlm.nih.gov/pubmed/16723258 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416479 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416479 RefSeq WP_000920120 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000920120 SMART SM00095 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00095 SMR P76341 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76341 STRING 511145.b1970 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1970&targetmode=cogs STRING COG2351 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2351&targetmode=cogs SUPFAM SSF49472 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49472 TIGRFAMs TIGR02962 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02962 UniProtKB HIUH_ECOLI http://www.uniprot.org/uniprot/HIUH_ECOLI UniProtKB-AC P76341 http://www.uniprot.org/uniprot/P76341 charge swissprot:HIUH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HIUH_ECOLI eggNOG COG2351 http://eggnogapi.embl.de/nog_data/html/tree/COG2351 eggNOG ENOG4105VT2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VT2 epestfind swissprot:HIUH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HIUH_ECOLI garnier swissprot:HIUH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HIUH_ECOLI helixturnhelix swissprot:HIUH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HIUH_ECOLI hmoment swissprot:HIUH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HIUH_ECOLI iep swissprot:HIUH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HIUH_ECOLI inforesidue swissprot:HIUH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HIUH_ECOLI octanol swissprot:HIUH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HIUH_ECOLI pepcoil swissprot:HIUH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HIUH_ECOLI pepdigest swissprot:HIUH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HIUH_ECOLI pepinfo swissprot:HIUH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HIUH_ECOLI pepnet swissprot:HIUH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HIUH_ECOLI pepstats swissprot:HIUH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HIUH_ECOLI pepwheel swissprot:HIUH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HIUH_ECOLI pepwindow swissprot:HIUH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HIUH_ECOLI sigcleave swissprot:HIUH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HIUH_ECOLI ## Database ID URL or Descriptions # BioGrid 4262584 22 # CDD cd06170 LuxR_C_like # ENZYME REGULATION Phosphorylation by UhpB enhances DNA binding activity. {ECO:0000269|PubMed 8999880}. # EcoGene EG11051 uhpA # FUNCTION UHPA_ECOLI Part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. Activates the transcription of the uhpT gene. Acts by binding specifically to the uhpT promoter region. {ECO 0000269|PubMed 3038843, ECO 0000269|PubMed 8999880}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_process GO:0000160 phosphorelay signal transduction system; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # IntAct P0AGA6 4 # InterPro IPR000792 Tscrpt_reg_LuxR_C # InterPro IPR001789 Sig_transdc_resp-reg_receiver # InterPro IPR011006 CheY-like_superfamily # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR016032 Sig_transdc_resp-reg_C-effctor # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02022 M00473 UhpB-UhpA (hexose phosphates uptake) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # Organism UHPA_ECOLI Escherichia coli (strain K12) # PATRIC 32122831 VBIEscCol129921_3791 # PIR A26925 BVECAU # PRINTS PR00038 HTHLUXR # PROSITE PS00622 HTH_LUXR_1 # PROSITE PS50043 HTH_LUXR_2 # PROSITE PS50110 RESPONSE_REGULATORY # PTM UHPA_ECOLI Phosphorylated and dephosphorylated by UhpB. {ECO 0000269|PubMed 11053370, ECO 0000269|PubMed 11739766}. # Pfam PF00072 Response_reg # Pfam PF00196 GerE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Transcriptional regulatory protein UhpA {ECO 0000305} # RefSeq NP_418125 NC_000913.3 # RefSeq WP_000633668 NZ_LN832404.1 # SIMILARITY Contains 1 HTH luxR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00411}. # SIMILARITY Contains 1 response regulatory domain. {ECO:0000255|PROSITE-ProRule PRU00169}. # SMART SM00421 HTH_LUXR # SMART SM00448 REC # SUBCELLULAR LOCATION UHPA_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF46894 SSF46894 # SUPFAM SSF52172 SSF52172 # eggNOG COG2197 LUCA # eggNOG ENOG4108KX4 Bacteria BLAST swissprot:UHPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UHPA_ECOLI BioCyc ECOL316407:JW3644-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3644-MONOMER BioCyc EcoCyc:UHPA-MONOMER http://biocyc.org/getid?id=EcoCyc:UHPA-MONOMER COG COG2197 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2197 DIP DIP-11082N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11082N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.272.3.1910 http://dx.doi.org/10.1074/jbc.272.3.1910 DOI 10.1099/00221287-147-12-3345 http://dx.doi.org/10.1099/00221287-147-12-3345 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.22.6279-6286.2000 http://dx.doi.org/10.1128/JB.182.22.6279-6286.2000 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M17102 http://www.ebi.ac.uk/ena/data/view/M17102 EMBL M89479 http://www.ebi.ac.uk/ena/data/view/M89479 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1044 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1044 EcoGene EG11051 http://www.ecogene.org/geneInfo.php?eg_id=EG11051 EnsemblBacteria AAC76692 http://www.ensemblgenomes.org/id/AAC76692 EnsemblBacteria AAC76692 http://www.ensemblgenomes.org/id/AAC76692 EnsemblBacteria BAE77624 http://www.ensemblgenomes.org/id/BAE77624 EnsemblBacteria BAE77624 http://www.ensemblgenomes.org/id/BAE77624 EnsemblBacteria BAE77624 http://www.ensemblgenomes.org/id/BAE77624 EnsemblBacteria b3669 http://www.ensemblgenomes.org/id/b3669 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 948178 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948178 HOGENOM HOG000034813 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000034813&db=HOGENOM6 InParanoid P0AGA6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGA6 IntAct P0AGA6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AGA6* InterPro IPR000792 http://www.ebi.ac.uk/interpro/entry/IPR000792 InterPro IPR001789 http://www.ebi.ac.uk/interpro/entry/IPR001789 InterPro IPR011006 http://www.ebi.ac.uk/interpro/entry/IPR011006 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR016032 http://www.ebi.ac.uk/interpro/entry/IPR016032 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW3644 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3644 KEGG_Gene eco:b3669 http://www.genome.jp/dbget-bin/www_bget?eco:b3669 KEGG_Orthology KO:K07686 http://www.genome.jp/dbget-bin/www_bget?KO:K07686 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA CIMLSVH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CIMLSVH PRINTS PR00038 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00038 PROSITE PS00622 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00622 PROSITE PS50043 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50043 PROSITE PS50110 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50110 PSORT swissprot:UHPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UHPA_ECOLI PSORT-B swissprot:UHPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UHPA_ECOLI PSORT2 swissprot:UHPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UHPA_ECOLI Pfam PF00072 http://pfam.xfam.org/family/PF00072 Pfam PF00196 http://pfam.xfam.org/family/PF00196 Phobius swissprot:UHPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UHPA_ECOLI PhylomeDB P0AGA6 http://phylomedb.org/?seqid=P0AGA6 ProteinModelPortal P0AGA6 http://www.proteinmodelportal.org/query/uniprot/P0AGA6 PubMed 11053370 http://www.ncbi.nlm.nih.gov/pubmed/11053370 PubMed 11739766 http://www.ncbi.nlm.nih.gov/pubmed/11739766 PubMed 1569007 http://www.ncbi.nlm.nih.gov/pubmed/1569007 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3038843 http://www.ncbi.nlm.nih.gov/pubmed/3038843 PubMed 3301805 http://www.ncbi.nlm.nih.gov/pubmed/3301805 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 8999880 http://www.ncbi.nlm.nih.gov/pubmed/8999880 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_418125 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418125 RefSeq WP_000633668 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000633668 SMART SM00421 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00421 SMART SM00448 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00448 SMR P0AGA6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AGA6 STRING 511145.b3669 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3669&targetmode=cogs STRING COG2197 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2197&targetmode=cogs SUPFAM SSF46894 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46894 SUPFAM SSF52172 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52172 UniProtKB UHPA_ECOLI http://www.uniprot.org/uniprot/UHPA_ECOLI UniProtKB-AC P0AGA6 http://www.uniprot.org/uniprot/P0AGA6 charge swissprot:UHPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UHPA_ECOLI eggNOG COG2197 http://eggnogapi.embl.de/nog_data/html/tree/COG2197 eggNOG ENOG4108KX4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108KX4 epestfind swissprot:UHPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UHPA_ECOLI garnier swissprot:UHPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UHPA_ECOLI helixturnhelix swissprot:UHPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UHPA_ECOLI hmoment swissprot:UHPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UHPA_ECOLI iep swissprot:UHPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UHPA_ECOLI inforesidue swissprot:UHPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UHPA_ECOLI octanol swissprot:UHPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UHPA_ECOLI pepcoil swissprot:UHPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UHPA_ECOLI pepdigest swissprot:UHPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UHPA_ECOLI pepinfo swissprot:UHPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UHPA_ECOLI pepnet swissprot:UHPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UHPA_ECOLI pepstats swissprot:UHPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UHPA_ECOLI pepwheel swissprot:UHPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UHPA_ECOLI pepwindow swissprot:UHPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UHPA_ECOLI sigcleave swissprot:UHPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UHPA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259274 161 # EcoGene EG12789 yhbT # GO_component GO:0005622 intracellular; IEA:GOC. # GO_process GO:0032365 intracellular lipid transport; IBA:GO_Central. # GOslim_component GO:0005622 intracellular # GOslim_process GO:0006810 transport # Gene3D 3.30.1050.10 -; 1. # IntAct P64599 6 # InterPro IPR003033 SCP2_sterol-bd_dom # InterPro IPR016830 UCP025550_lipid_carrier # Organism YHBT_ECOLI Escherichia coli (strain K12) # PATRIC 32121732 VBIEscCol129921_3252 # PIR A65106 A65106 # PIRSF PIRSF025550 UCP025550_lpd_carrier # Pfam PF02036 SCP2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHBT_ECOLI Uncharacterized protein YhbT # RefSeq NP_417626 NC_000913.3 # RefSeq WP_001295552 NZ_LN832404.1 # SUPFAM SSF55718 SSF55718 # eggNOG COG3154 LUCA # eggNOG ENOG4105XPQ Bacteria BLAST swissprot:YHBT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHBT_ECOLI BioCyc ECOL316407:JW3126-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3126-MONOMER BioCyc EcoCyc:G7651-MONOMER http://biocyc.org/getid?id=EcoCyc:G7651-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2641 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2641 EcoGene EG12789 http://www.ecogene.org/geneInfo.php?eg_id=EG12789 EnsemblBacteria AAC76191 http://www.ensemblgenomes.org/id/AAC76191 EnsemblBacteria AAC76191 http://www.ensemblgenomes.org/id/AAC76191 EnsemblBacteria BAE77203 http://www.ensemblgenomes.org/id/BAE77203 EnsemblBacteria BAE77203 http://www.ensemblgenomes.org/id/BAE77203 EnsemblBacteria BAE77203 http://www.ensemblgenomes.org/id/BAE77203 EnsemblBacteria b3157 http://www.ensemblgenomes.org/id/b3157 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_process GO:0032365 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032365 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.30.1050.10 http://www.cathdb.info/version/latest/superfamily/3.30.1050.10 GeneID 947669 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947669 HOGENOM HOG000276109 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276109&db=HOGENOM6 InParanoid P64599 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P64599 IntAct P64599 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P64599* InterPro IPR003033 http://www.ebi.ac.uk/interpro/entry/IPR003033 InterPro IPR016830 http://www.ebi.ac.uk/interpro/entry/IPR016830 KEGG_Gene ecj:JW3126 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3126 KEGG_Gene eco:b3157 http://www.genome.jp/dbget-bin/www_bget?eco:b3157 OMA FTPFALQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FTPFALQ PSORT swissprot:YHBT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHBT_ECOLI PSORT-B swissprot:YHBT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHBT_ECOLI PSORT2 swissprot:YHBT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHBT_ECOLI Pfam PF02036 http://pfam.xfam.org/family/PF02036 Phobius swissprot:YHBT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHBT_ECOLI ProteinModelPortal P64599 http://www.proteinmodelportal.org/query/uniprot/P64599 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417626 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417626 RefSeq WP_001295552 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295552 STRING 511145.b3157 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3157&targetmode=cogs SUPFAM SSF55718 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55718 UniProtKB YHBT_ECOLI http://www.uniprot.org/uniprot/YHBT_ECOLI UniProtKB-AC P64599 http://www.uniprot.org/uniprot/P64599 charge swissprot:YHBT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHBT_ECOLI eggNOG COG3154 http://eggnogapi.embl.de/nog_data/html/tree/COG3154 eggNOG ENOG4105XPQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105XPQ epestfind swissprot:YHBT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHBT_ECOLI garnier swissprot:YHBT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHBT_ECOLI helixturnhelix swissprot:YHBT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHBT_ECOLI hmoment swissprot:YHBT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHBT_ECOLI iep swissprot:YHBT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHBT_ECOLI inforesidue swissprot:YHBT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHBT_ECOLI octanol swissprot:YHBT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHBT_ECOLI pepcoil swissprot:YHBT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHBT_ECOLI pepdigest swissprot:YHBT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHBT_ECOLI pepinfo swissprot:YHBT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHBT_ECOLI pepnet swissprot:YHBT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHBT_ECOLI pepstats swissprot:YHBT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHBT_ECOLI pepwheel swissprot:YHBT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHBT_ECOLI pepwindow swissprot:YHBT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHBT_ECOLI sigcleave swissprot:YHBT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHBT_ECOLI ## Database ID URL or Descriptions # AltName HYCG_ECOLI Hydrogenase-3 component G # BioGrid 4262939 15 # COFACTOR HYCG_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000305}; Note=Binds 1 [4Fe-4S] cluster. {ECO 0000305}; # EcoGene EG10480 hycG # GO_function GO:0008137 NADH dehydrogenase (ubiquinone) activity; IEA:InterPro. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0048038 quinone binding; IEA:InterPro. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.700 -; 1. # INTERACTION HYCG_ECOLI P07658 fdhF; NbExp=3; IntAct=EBI-541977, EBI-1121603; P30750 metN; NbExp=5; IntAct=EBI-541977, EBI-541886; P0A9F1 mntR; NbExp=4; IntAct=EBI-541977, EBI-541895; # IntAct P16433 10 # InterPro IPR006137 NADH_UbQ_OxRdtase-like_20kDa # InterPro IPR006138 NADH_UQ_OxRdtase_20Kd_su # Organism HYCG_ECOLI Escherichia coli (strain K12) # PATRIC 32120838 VBIEscCol129921_2811 # PIR S08625 S08625 # PROSITE PS01150 COMPLEX1_20K # Pfam PF01058 Oxidored_q6 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HYCG_ECOLI Formate hydrogenlyase subunit 7 # RefSeq NP_417199 NC_000913.3 # RefSeq WP_000067392 NZ_LN832404.1 # SIMILARITY Belongs to the complex I 20 kDa subunit family. {ECO 0000305}. # SUBUNIT HYCG_ECOLI FHL comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (isoenzyme 3). In this non- energy conserving pathway molecular hydrogen and carbodioxide from formate are released. # TCDB 3.D.1.9 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family # eggNOG COG3260 LUCA # eggNOG ENOG4105C47 Bacteria BLAST swissprot:HYCG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HYCG_ECOLI BioCyc ECOL316407:JW2689-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2689-MONOMER BioCyc EcoCyc:HYCG-MONOMER http://biocyc.org/getid?id=EcoCyc:HYCG-MONOMER BioCyc MetaCyc:HYCG-MONOMER http://biocyc.org/getid?id=MetaCyc:HYCG-MONOMER COG COG3260 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3260 DIP DIP-9977N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9977N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1990.tb00590.x http://dx.doi.org/10.1111/j.1365-2958.1990.tb00590.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EMBL X17506 http://www.ebi.ac.uk/ena/data/view/X17506 EchoBASE EB0475 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0475 EcoGene EG10480 http://www.ecogene.org/geneInfo.php?eg_id=EG10480 EnsemblBacteria AAC75761 http://www.ensemblgenomes.org/id/AAC75761 EnsemblBacteria AAC75761 http://www.ensemblgenomes.org/id/AAC75761 EnsemblBacteria BAE76796 http://www.ensemblgenomes.org/id/BAE76796 EnsemblBacteria BAE76796 http://www.ensemblgenomes.org/id/BAE76796 EnsemblBacteria BAE76796 http://www.ensemblgenomes.org/id/BAE76796 EnsemblBacteria b2719 http://www.ensemblgenomes.org/id/b2719 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008137 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008137 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0048038 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048038 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.700 http://www.cathdb.info/version/latest/superfamily/3.40.50.700 GeneID 947191 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947191 HOGENOM HOG000228250 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000228250&db=HOGENOM6 InParanoid P16433 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P16433 IntAct P16433 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P16433* InterPro IPR006137 http://www.ebi.ac.uk/interpro/entry/IPR006137 InterPro IPR006138 http://www.ebi.ac.uk/interpro/entry/IPR006138 KEGG_Gene ecj:JW2689 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2689 KEGG_Gene eco:b2719 http://www.genome.jp/dbget-bin/www_bget?eco:b2719 KEGG_Orthology KO:K15832 http://www.genome.jp/dbget-bin/www_bget?KO:K15832 MINT MINT-1287919 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1287919 OMA CIAYGAC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CIAYGAC PROSITE PS01150 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01150 PSORT swissprot:HYCG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HYCG_ECOLI PSORT-B swissprot:HYCG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HYCG_ECOLI PSORT2 swissprot:HYCG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HYCG_ECOLI Pfam PF01058 http://pfam.xfam.org/family/PF01058 Phobius swissprot:HYCG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HYCG_ECOLI PhylomeDB P16433 http://phylomedb.org/?seqid=P16433 ProteinModelPortal P16433 http://www.proteinmodelportal.org/query/uniprot/P16433 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2187144 http://www.ncbi.nlm.nih.gov/pubmed/2187144 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417199 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417199 RefSeq WP_000067392 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000067392 STRING 511145.b2719 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2719&targetmode=cogs STRING COG3260 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3260&targetmode=cogs TCDB 3.D.1.9 http://www.tcdb.org/search/result.php?tc=3.D.1.9 UniProtKB HYCG_ECOLI http://www.uniprot.org/uniprot/HYCG_ECOLI UniProtKB-AC P16433 http://www.uniprot.org/uniprot/P16433 charge swissprot:HYCG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HYCG_ECOLI eggNOG COG3260 http://eggnogapi.embl.de/nog_data/html/tree/COG3260 eggNOG ENOG4105C47 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C47 epestfind swissprot:HYCG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HYCG_ECOLI garnier swissprot:HYCG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HYCG_ECOLI helixturnhelix swissprot:HYCG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HYCG_ECOLI hmoment swissprot:HYCG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HYCG_ECOLI iep swissprot:HYCG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HYCG_ECOLI inforesidue swissprot:HYCG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HYCG_ECOLI octanol swissprot:HYCG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HYCG_ECOLI pepcoil swissprot:HYCG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HYCG_ECOLI pepdigest swissprot:HYCG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HYCG_ECOLI pepinfo swissprot:HYCG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HYCG_ECOLI pepnet swissprot:HYCG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HYCG_ECOLI pepstats swissprot:HYCG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HYCG_ECOLI pepwheel swissprot:HYCG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HYCG_ECOLI pepwindow swissprot:HYCG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HYCG_ECOLI sigcleave swissprot:HYCG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HYCG_ECOLI ## Database ID URL or Descriptions # BioGrid 4259108 5 # EcoGene EG13768 ydcY # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # INTERACTION YDCY_ECOLI P0A9N4 pflA; NbExp=4; IntAct=EBI-9129853, EBI-1114060; # IntAct P64455 9 # InterPro IPR019671 DUF2526 # Organism YDCY_ECOLI Escherichia coli (strain K12) # PATRIC 32118184 VBIEscCol129921_1512 # PIR A64897 A64897 # Pfam PF10735 DUF2526 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDCY_ECOLI Uncharacterized protein YdcY # RefSeq NP_415963 NC_000913.3 # RefSeq WP_000018633 NZ_LN832404.1 # eggNOG ENOG4105R71 Bacteria # eggNOG ENOG4111WST LUCA BLAST swissprot:YDCY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDCY_ECOLI BioCyc ECOL316407:JW1441-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1441-MONOMER BioCyc EcoCyc:G6757-MONOMER http://biocyc.org/getid?id=EcoCyc:G6757-MONOMER DIP DIP-47884N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47884N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3531 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3531 EcoGene EG13768 http://www.ecogene.org/geneInfo.php?eg_id=EG13768 EnsemblBacteria AAC74528 http://www.ensemblgenomes.org/id/AAC74528 EnsemblBacteria AAC74528 http://www.ensemblgenomes.org/id/AAC74528 EnsemblBacteria BAE76442 http://www.ensemblgenomes.org/id/BAE76442 EnsemblBacteria BAE76442 http://www.ensemblgenomes.org/id/BAE76442 EnsemblBacteria BAE76442 http://www.ensemblgenomes.org/id/BAE76442 EnsemblBacteria b1446 http://www.ensemblgenomes.org/id/b1446 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GeneID 945916 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945916 HOGENOM HOG000267919 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267919&db=HOGENOM6 InParanoid P64455 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P64455 IntAct P64455 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P64455* InterPro IPR019671 http://www.ebi.ac.uk/interpro/entry/IPR019671 KEGG_Gene ecj:JW1441 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1441 KEGG_Gene eco:b1446 http://www.genome.jp/dbget-bin/www_bget?eco:b1446 OMA HGRQHKE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HGRQHKE PSORT swissprot:YDCY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDCY_ECOLI PSORT-B swissprot:YDCY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDCY_ECOLI PSORT2 swissprot:YDCY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDCY_ECOLI Pfam PF10735 http://pfam.xfam.org/family/PF10735 Phobius swissprot:YDCY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDCY_ECOLI ProteinModelPortal P64455 http://www.proteinmodelportal.org/query/uniprot/P64455 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415963 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415963 RefSeq WP_000018633 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000018633 SMR P64455 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P64455 STRING 511145.b1446 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1446&targetmode=cogs UniProtKB YDCY_ECOLI http://www.uniprot.org/uniprot/YDCY_ECOLI UniProtKB-AC P64455 http://www.uniprot.org/uniprot/P64455 charge swissprot:YDCY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDCY_ECOLI eggNOG ENOG4105R71 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105R71 eggNOG ENOG4111WST http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111WST epestfind swissprot:YDCY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDCY_ECOLI garnier swissprot:YDCY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDCY_ECOLI helixturnhelix swissprot:YDCY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDCY_ECOLI hmoment swissprot:YDCY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDCY_ECOLI iep swissprot:YDCY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDCY_ECOLI inforesidue swissprot:YDCY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDCY_ECOLI octanol swissprot:YDCY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDCY_ECOLI pepcoil swissprot:YDCY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDCY_ECOLI pepdigest swissprot:YDCY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDCY_ECOLI pepinfo swissprot:YDCY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDCY_ECOLI pepnet swissprot:YDCY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDCY_ECOLI pepstats swissprot:YDCY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDCY_ECOLI pepwheel swissprot:YDCY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDCY_ECOLI pepwindow swissprot:YDCY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDCY_ECOLI sigcleave swissprot:YDCY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDCY_ECOLI ## Database ID URL or Descriptions # BioGrid 4263000 209 # EcoGene EG11124 ompW # FUNCTION OMPW_ECOLI Acts as a receptor for colicin S4. {ECO 0000269|PubMed 10348872}. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # Gene3D 2.40.160.20 -; 1. # INTERACTION OMPW_ECOLI P0AC47 frdB; NbExp=2; IntAct=EBI-1132929, EBI-906724; # IntAct P0A915 5 # InterPro IPR005618 OMPW # InterPro IPR011250 OMP/PagP_b-brl # Organism OMPW_ECOLI Escherichia coli (strain K12) # PATRIC 32117772 VBIEscCol129921_1306 # PDB 2F1T X-ray; 3.00 A; A/B/C=22-212 # PDB 2F1V X-ray; 2.70 A; A/B/C/D/E/F=22-212 # PIR S07797 S07797 # PIR T45501 T45501 # Pfam PF03922 OmpW # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName OMPW_ECOLI Outer membrane protein W # RefSeq NP_415772 NC_000913.3 # RefSeq WP_000737226 NZ_LN832404.1 # SIMILARITY Belongs to the OmpW/AlkL family. {ECO 0000305}. # SUBCELLULAR LOCATION OMPW_ECOLI Cell outer membrane. # SUPFAM SSF56925 SSF56925 # TCDB 1.B.39.1 the bacterial porin, ompw (ompw) family # eggNOG COG3047 LUCA # eggNOG ENOG4105EIF Bacteria BLAST swissprot:OMPW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:OMPW_ECOLI BioCyc ECOL316407:JW1248-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1248-MONOMER BioCyc EcoCyc:EG11124-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11124-MONOMER COG COG3047 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3047 DOI 10.1002/elps.1150190539 http://dx.doi.org/10.1002/elps.1150190539 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U24195 http://www.ebi.ac.uk/ena/data/view/U24195 EMBL U24196 http://www.ebi.ac.uk/ena/data/view/U24196 EMBL U24197 http://www.ebi.ac.uk/ena/data/view/U24197 EMBL U24198 http://www.ebi.ac.uk/ena/data/view/U24198 EMBL U24199 http://www.ebi.ac.uk/ena/data/view/U24199 EMBL U24200 http://www.ebi.ac.uk/ena/data/view/U24200 EMBL U24201 http://www.ebi.ac.uk/ena/data/view/U24201 EMBL U24202 http://www.ebi.ac.uk/ena/data/view/U24202 EMBL U24203 http://www.ebi.ac.uk/ena/data/view/U24203 EMBL U24204 http://www.ebi.ac.uk/ena/data/view/U24204 EMBL U24205 http://www.ebi.ac.uk/ena/data/view/U24205 EMBL U24206 http://www.ebi.ac.uk/ena/data/view/U24206 EMBL X13583 http://www.ebi.ac.uk/ena/data/view/X13583 EchoBASE EB1114 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1114 EcoGene EG11124 http://www.ecogene.org/geneInfo.php?eg_id=EG11124 EnsemblBacteria AAC74338 http://www.ensemblgenomes.org/id/AAC74338 EnsemblBacteria AAC74338 http://www.ensemblgenomes.org/id/AAC74338 EnsemblBacteria BAA14788 http://www.ensemblgenomes.org/id/BAA14788 EnsemblBacteria BAA14788 http://www.ensemblgenomes.org/id/BAA14788 EnsemblBacteria BAA14788 http://www.ensemblgenomes.org/id/BAA14788 EnsemblBacteria b1256 http://www.ensemblgenomes.org/id/b1256 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 Gene3D 2.40.160.20 http://www.cathdb.info/version/latest/superfamily/2.40.160.20 GeneID 945128 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945128 HOGENOM HOG000217796 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000217796&db=HOGENOM6 InParanoid P0A915 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A915 IntAct P0A915 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A915* InterPro IPR005618 http://www.ebi.ac.uk/interpro/entry/IPR005618 InterPro IPR011250 http://www.ebi.ac.uk/interpro/entry/IPR011250 KEGG_Gene ecj:JW1248 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1248 KEGG_Gene eco:b1256 http://www.genome.jp/dbget-bin/www_bget?eco:b1256 KEGG_Orthology KO:K07275 http://www.genome.jp/dbget-bin/www_bget?KO:K07275 OMA DYMLTDN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DYMLTDN PDB 2F1T http://www.ebi.ac.uk/pdbe-srv/view/entry/2F1T PDB 2F1V http://www.ebi.ac.uk/pdbe-srv/view/entry/2F1V PDBsum 2F1T http://www.ebi.ac.uk/pdbsum/2F1T PDBsum 2F1V http://www.ebi.ac.uk/pdbsum/2F1V PSORT swissprot:OMPW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:OMPW_ECOLI PSORT-B swissprot:OMPW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:OMPW_ECOLI PSORT2 swissprot:OMPW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:OMPW_ECOLI Pfam PF03922 http://pfam.xfam.org/family/PF03922 Phobius swissprot:OMPW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:OMPW_ECOLI PhylomeDB P0A915 http://phylomedb.org/?seqid=P0A915 ProteinModelPortal P0A915 http://www.proteinmodelportal.org/query/uniprot/P0A915 PubMed 10348872 http://www.ncbi.nlm.nih.gov/pubmed/10348872 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3058546 http://www.ncbi.nlm.nih.gov/pubmed/3058546 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9629924 http://www.ncbi.nlm.nih.gov/pubmed/9629924 RefSeq NP_415772 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415772 RefSeq WP_000737226 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000737226 SMR P0A915 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A915 STRING 511145.b1256 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1256&targetmode=cogs STRING COG3047 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3047&targetmode=cogs SUPFAM SSF56925 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56925 TCDB 1.B.39.1 http://www.tcdb.org/search/result.php?tc=1.B.39.1 UniProtKB OMPW_ECOLI http://www.uniprot.org/uniprot/OMPW_ECOLI UniProtKB-AC P0A915 http://www.uniprot.org/uniprot/P0A915 charge swissprot:OMPW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:OMPW_ECOLI eggNOG COG3047 http://eggnogapi.embl.de/nog_data/html/tree/COG3047 eggNOG ENOG4105EIF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EIF epestfind swissprot:OMPW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:OMPW_ECOLI garnier swissprot:OMPW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:OMPW_ECOLI helixturnhelix swissprot:OMPW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:OMPW_ECOLI hmoment swissprot:OMPW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:OMPW_ECOLI iep swissprot:OMPW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:OMPW_ECOLI inforesidue swissprot:OMPW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:OMPW_ECOLI octanol swissprot:OMPW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:OMPW_ECOLI pepcoil swissprot:OMPW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:OMPW_ECOLI pepdigest swissprot:OMPW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:OMPW_ECOLI pepinfo swissprot:OMPW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:OMPW_ECOLI pepnet swissprot:OMPW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:OMPW_ECOLI pepstats swissprot:OMPW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:OMPW_ECOLI pepwheel swissprot:OMPW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:OMPW_ECOLI pepwindow swissprot:OMPW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:OMPW_ECOLI sigcleave swissprot:OMPW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:OMPW_ECOLI ## Database ID URL or Descriptions # BioGrid 4259984 14 # CDD cd06261 TM_PBP2 # EcoGene EG13475 gsiD # FUNCTION GSID_ECOLI Part of the ABC transporter complex GsiABCD involved in glutathione import. Probably responsible for the translocation of the substrate across the membrane (Probable). {ECO 0000305|PubMed 16109926}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0034634 glutathione transmembrane transporter activity; IDA:EcoCyc. # GO_process GO:0034775 glutathione transmembrane transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0055085 transmembrane transport # Gene3D 1.10.3720.10 -; 1. # InterPro IPR000515 MetI-like # InterPro IPR025966 OppC_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00348 Glutathione transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism GSID_ECOLI Escherichia coli (strain K12) # PATRIC 32116867 VBIEscCol129921_0859 # PIR H64820 H64820 # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Pfam PF12911 OppC_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GSID_ECOLI Glutathione transport system permease protein GsiD # RefSeq NP_415353 NC_000913.3 # RefSeq WP_001236051 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION GSID_ECOLI Cell inner membrane {ECO 0000250}; Multi- pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00441}. # SUBUNIT The complex is composed of two ATP-binding proteins (GsiA), two transmembrane proteins (GsiC and GsiD) and a solute- binding protein (GsiB). {ECO 0000305}. # SUPFAM SSF161098 SSF161098 # TCDB 3.A.1.5.11 the atp-binding cassette (abc) superfamily # eggNOG COG1173 LUCA # eggNOG ENOG4105C2T Bacteria BLAST swissprot:GSID_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GSID_ECOLI BioCyc ECOL316407:JW0816-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0816-MONOMER BioCyc EcoCyc:YLID-MONOMER http://biocyc.org/getid?id=EcoCyc:YLID-MONOMER BioCyc MetaCyc:YLID-MONOMER http://biocyc.org/getid?id=MetaCyc:YLID-MONOMER COG COG1173 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1173 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.187.17.5861-5867.2005 http://dx.doi.org/10.1128/JB.187.17.5861-5867.2005 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3248 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3248 EcoGene EG13475 http://www.ecogene.org/geneInfo.php?eg_id=EG13475 EnsemblBacteria AAC73919 http://www.ensemblgenomes.org/id/AAC73919 EnsemblBacteria AAC73919 http://www.ensemblgenomes.org/id/AAC73919 EnsemblBacteria BAA35527 http://www.ensemblgenomes.org/id/BAA35527 EnsemblBacteria BAA35527 http://www.ensemblgenomes.org/id/BAA35527 EnsemblBacteria BAA35527 http://www.ensemblgenomes.org/id/BAA35527 EnsemblBacteria b0832 http://www.ensemblgenomes.org/id/b0832 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0034634 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034634 GO_process GO:0034775 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034775 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 945461 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945461 HOGENOM HOG000171368 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000171368&db=HOGENOM6 InParanoid P75799 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75799 InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 InterPro IPR025966 http://www.ebi.ac.uk/interpro/entry/IPR025966 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0816 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0816 KEGG_Gene eco:b0832 http://www.genome.jp/dbget-bin/www_bget?eco:b0832 KEGG_Orthology KO:K13891 http://www.genome.jp/dbget-bin/www_bget?KO:K13891 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA FTLMIQA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FTLMIQA PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:GSID_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GSID_ECOLI PSORT-B swissprot:GSID_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GSID_ECOLI PSORT2 swissprot:GSID_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GSID_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Pfam PF12911 http://pfam.xfam.org/family/PF12911 Phobius swissprot:GSID_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GSID_ECOLI PhylomeDB P75799 http://phylomedb.org/?seqid=P75799 ProteinModelPortal P75799 http://www.proteinmodelportal.org/query/uniprot/P75799 PubMed 16109926 http://www.ncbi.nlm.nih.gov/pubmed/16109926 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415353 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415353 RefSeq WP_001236051 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001236051 SMR P75799 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75799 STRING 511145.b0832 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0832&targetmode=cogs STRING COG1173 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1173&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.5.11 http://www.tcdb.org/search/result.php?tc=3.A.1.5.11 UniProtKB GSID_ECOLI http://www.uniprot.org/uniprot/GSID_ECOLI UniProtKB-AC P75799 http://www.uniprot.org/uniprot/P75799 charge swissprot:GSID_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GSID_ECOLI eggNOG COG1173 http://eggnogapi.embl.de/nog_data/html/tree/COG1173 eggNOG ENOG4105C2T http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C2T epestfind swissprot:GSID_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GSID_ECOLI garnier swissprot:GSID_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GSID_ECOLI helixturnhelix swissprot:GSID_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GSID_ECOLI hmoment swissprot:GSID_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GSID_ECOLI iep swissprot:GSID_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GSID_ECOLI inforesidue swissprot:GSID_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GSID_ECOLI octanol swissprot:GSID_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GSID_ECOLI pepcoil swissprot:GSID_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GSID_ECOLI pepdigest swissprot:GSID_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GSID_ECOLI pepinfo swissprot:GSID_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GSID_ECOLI pepnet swissprot:GSID_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GSID_ECOLI pepstats swissprot:GSID_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GSID_ECOLI pepwheel swissprot:GSID_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GSID_ECOLI pepwindow swissprot:GSID_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GSID_ECOLI sigcleave swissprot:GSID_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GSID_ECOLI ## Database ID URL or Descriptions # BioGrid 4261676 5 # CATALYTIC ACTIVITY NIFJ_ECOLI Pyruvate + CoA + oxidized flavodoxin = acetyl- CoA + CO(2) + reduced flavodoxin. # COFACTOR NIFJ_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000250|UniProtKB P94692}; Note=Binds 3 [4Fe-4S] clusters per subunit. {ECO 0000250|UniProtKB P94692}; # DrugBank DB00698 Nitrofurantoin # EcoGene EG13183 ydbK # FUNCTION NIFJ_ECOLI Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin. {ECO 0000305}. # GO_function GO:0005506 iron ion binding; IEA:InterPro. # GO_function GO:0030976 thiamine pyrophosphate binding; IEA:InterPro. # GO_function GO:0043873 pyruvate-flavodoxin oxidoreductase activity; IDA:EcoCyc. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0006979 response to oxidative stress; IMP:EcoCyc. # GO_process GO:0022900 electron transport chain; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0006950 response to stress # Gene3D 3.40.50.920 -; 1. # Gene3D 3.40.50.970 -; 2. # Gene3D 3.40.920.10 -; 1. # Gene3D 4.10.780.10 -; 1. # IntAct P52647 10 # InterPro IPR002869 Pyrv_flavodox_OxRed_cen # InterPro IPR002880 Pyrv_Fd/Flavodoxin_OxRdtase_N # InterPro IPR009014 Transketo_C/PFOR_II # InterPro IPR011766 TPP_enzyme-bd_C # InterPro IPR011895 Pyrv_flavodox_OxRed # InterPro IPR017896 4Fe4S_Fe-S-bd # InterPro IPR017900 4Fe4S_Fe_S_CS # InterPro IPR019456 Pyrv-flavodox_OxRtase_EKR # InterPro IPR019752 Pyrv/ketoisovalerate_OxRed_cat # InterPro IPR029061 THDP-binding # InterPro IPR033412 PFOR_II # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00720 Carbon fixation pathways in prokaryotes # KEGG_Pathway ko00910 Nitrogen metabolism # Organism NIFJ_ECOLI Escherichia coli (strain K12) # PATRIC 32118040 VBIEscCol129921_1440 # PIR E64888 E64888 # PIRSF PIRSF000159 NifJ # PROSITE PS00198 4FE4S_FER_1; 2 # PROSITE PS51379 4FE4S_FER_2; 2 # Pfam PF01558 POR # Pfam PF01855 POR_N # Pfam PF02775 TPP_enzyme_C # Pfam PF10371 EKR # Pfam PF17147 PFOR_II # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NIFJ_ECOLI Probable pyruvate-flavodoxin oxidoreductase # RefSeq NP_415896 NC_000913.3 # RefSeq WP_000628244 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=U36928; Type=Frameshift; Positions=35; Evidence={ECO 0000305}; # SIMILARITY Belongs to the NifJ family. {ECO 0000305}. # SIMILARITY Contains 2 4Fe-4S ferredoxin-type domains. {ECO:0000255|PROSITE-ProRule PRU00711}. # SMART SM00890 EKR # SUPFAM SSF52518 SSF52518; 2 # SUPFAM SSF52922 SSF52922 # SUPFAM SSF53323 SSF53323 # TIGRFAMs TIGR02176 pyruv_ox_red # eggNOG COG0674 LUCA # eggNOG COG1013 LUCA # eggNOG COG1014 LUCA # eggNOG ENOG4105D95 Bacteria BLAST swissprot:NIFJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NIFJ_ECOLI BioCyc ECOL316407:JW1372-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1372-MONOMER BioCyc EcoCyc:G6701-MONOMER http://biocyc.org/getid?id=EcoCyc:G6701-MONOMER BioCyc MetaCyc:G6701-MONOMER http://biocyc.org/getid?id=MetaCyc:G6701-MONOMER COG COG0674 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0674 COG COG1013 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1013 COG COG1014 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1014 DIP DIP-11636N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11636N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1099/00221287-143-1-187 http://dx.doi.org/10.1099/00221287-143-1-187 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB00698 http://www.drugbank.ca/drugs/DB00698 EC_number EC:1.2.7.- http://www.genome.jp/dbget-bin/www_bget?EC:1.2.7.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36928 http://www.ebi.ac.uk/ena/data/view/U36928 ENZYME 1.2.7.- http://enzyme.expasy.org/EC/1.2.7.- EchoBASE EB2975 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2975 EcoGene EG13183 http://www.ecogene.org/geneInfo.php?eg_id=EG13183 EnsemblBacteria AAC74460 http://www.ensemblgenomes.org/id/AAC74460 EnsemblBacteria AAC74460 http://www.ensemblgenomes.org/id/AAC74460 EnsemblBacteria BAA14982 http://www.ensemblgenomes.org/id/BAA14982 EnsemblBacteria BAA14982 http://www.ensemblgenomes.org/id/BAA14982 EnsemblBacteria BAA14982 http://www.ensemblgenomes.org/id/BAA14982 EnsemblBacteria b1378 http://www.ensemblgenomes.org/id/b1378 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0030976 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030976 GO_function GO:0043873 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043873 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0006979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979 GO_process GO:0022900 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022900 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.40.50.920 http://www.cathdb.info/version/latest/superfamily/3.40.50.920 Gene3D 3.40.50.970 http://www.cathdb.info/version/latest/superfamily/3.40.50.970 Gene3D 3.40.920.10 http://www.cathdb.info/version/latest/superfamily/3.40.920.10 Gene3D 4.10.780.10 http://www.cathdb.info/version/latest/superfamily/4.10.780.10 GeneID 946587 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946587 HOGENOM HOG000266425 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000266425&db=HOGENOM6 InParanoid P52647 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P52647 IntAct P52647 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P52647* IntEnz 1.2.7 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.2.7 InterPro IPR002869 http://www.ebi.ac.uk/interpro/entry/IPR002869 InterPro IPR002880 http://www.ebi.ac.uk/interpro/entry/IPR002880 InterPro IPR009014 http://www.ebi.ac.uk/interpro/entry/IPR009014 InterPro IPR011766 http://www.ebi.ac.uk/interpro/entry/IPR011766 InterPro IPR011895 http://www.ebi.ac.uk/interpro/entry/IPR011895 InterPro IPR017896 http://www.ebi.ac.uk/interpro/entry/IPR017896 InterPro IPR017900 http://www.ebi.ac.uk/interpro/entry/IPR017900 InterPro IPR019456 http://www.ebi.ac.uk/interpro/entry/IPR019456 InterPro IPR019752 http://www.ebi.ac.uk/interpro/entry/IPR019752 InterPro IPR029061 http://www.ebi.ac.uk/interpro/entry/IPR029061 InterPro IPR033412 http://www.ebi.ac.uk/interpro/entry/IPR033412 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1372 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1372 KEGG_Gene eco:b1378 http://www.genome.jp/dbget-bin/www_bget?eco:b1378 KEGG_Orthology KO:K03737 http://www.genome.jp/dbget-bin/www_bget?KO:K03737 KEGG_Pathway ko00720 http://www.genome.jp/kegg-bin/show_pathway?ko00720 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Reaction rn:R01196 http://www.genome.jp/dbget-bin/www_bget?rn:R01196 MINT MINT-1299276 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1299276 OMA MQACFFA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MQACFFA PROSITE PS00198 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00198 PROSITE PS51379 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51379 PSORT swissprot:NIFJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NIFJ_ECOLI PSORT-B swissprot:NIFJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NIFJ_ECOLI PSORT2 swissprot:NIFJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NIFJ_ECOLI Pfam PF01558 http://pfam.xfam.org/family/PF01558 Pfam PF01855 http://pfam.xfam.org/family/PF01855 Pfam PF02775 http://pfam.xfam.org/family/PF02775 Pfam PF10371 http://pfam.xfam.org/family/PF10371 Pfam PF17147 http://pfam.xfam.org/family/PF17147 Phobius swissprot:NIFJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NIFJ_ECOLI PhylomeDB P52647 http://phylomedb.org/?seqid=P52647 ProteinModelPortal P52647 http://www.proteinmodelportal.org/query/uniprot/P52647 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9025293 http://www.ncbi.nlm.nih.gov/pubmed/9025293 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415896 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415896 RefSeq WP_000628244 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000628244 SMART SM00890 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00890 SMR P52647 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P52647 STRING 511145.b1378 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1378&targetmode=cogs STRING COG0674 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0674&targetmode=cogs STRING COG1013 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1013&targetmode=cogs STRING COG1014 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1014&targetmode=cogs SUPFAM SSF52518 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52518 SUPFAM SSF52922 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52922 SUPFAM SSF53323 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53323 TIGRFAMs TIGR02176 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02176 UniProtKB NIFJ_ECOLI http://www.uniprot.org/uniprot/NIFJ_ECOLI UniProtKB-AC P52647 http://www.uniprot.org/uniprot/P52647 charge swissprot:NIFJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NIFJ_ECOLI eggNOG COG0674 http://eggnogapi.embl.de/nog_data/html/tree/COG0674 eggNOG COG1013 http://eggnogapi.embl.de/nog_data/html/tree/COG1013 eggNOG COG1014 http://eggnogapi.embl.de/nog_data/html/tree/COG1014 eggNOG ENOG4105D95 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D95 epestfind swissprot:NIFJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NIFJ_ECOLI garnier swissprot:NIFJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NIFJ_ECOLI helixturnhelix swissprot:NIFJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NIFJ_ECOLI hmoment swissprot:NIFJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NIFJ_ECOLI iep swissprot:NIFJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NIFJ_ECOLI inforesidue swissprot:NIFJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NIFJ_ECOLI octanol swissprot:NIFJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NIFJ_ECOLI pepcoil swissprot:NIFJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NIFJ_ECOLI pepdigest swissprot:NIFJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NIFJ_ECOLI pepinfo swissprot:NIFJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NIFJ_ECOLI pepnet swissprot:NIFJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NIFJ_ECOLI pepstats swissprot:NIFJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NIFJ_ECOLI pepwheel swissprot:NIFJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NIFJ_ECOLI pepwindow swissprot:NIFJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NIFJ_ECOLI sigcleave swissprot:NIFJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NIFJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4260459 7 # EcoGene EG12029 nupX # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0005337 nucleoside transmembrane transporter activity; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # InterPro IPR002668 CNT_N_dom # InterPro IPR008276 C_nuclsd_transpt # InterPro IPR011657 CNT_C_dom # InterPro IPR018270 C_nuclsd_transpt_met_bac # KEGG_Brite ko02000 Transporters # Organism NUPX_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10590 PTHR10590 # PATRIC 32119671 VBIEscCol129921_2246 # PIR H64984 H64984 # Pfam PF01773 Nucleos_tra2_N # Pfam PF07662 Nucleos_tra2_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Putative nucleoside permease NupX {ECO 0000305} # RefSeq NP_416666 NC_000913.3 # RefSeq WP_000382966 NZ_LN832404.1 # SIMILARITY Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family. {ECO 0000305}. # SUBCELLULAR LOCATION NUPX_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255}. # TCDB 2.A.41.2.10 the concentrative nucleoside transporter (cnt) family # TIGRFAMs TIGR00804 nupC # eggNOG COG1972 LUCA # eggNOG ENOG4105D9N Bacteria BLAST swissprot:NUPX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NUPX_ECOLI BioCyc ECOL316407:JW2148-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2148-MONOMER BioCyc EcoCyc:YEIJ-MONOMER http://biocyc.org/getid?id=EcoCyc:YEIJ-MONOMER COG COG1972 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1972 DIP DIP-11922N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11922N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1964 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1964 EcoGene EG12029 http://www.ecogene.org/geneInfo.php?eg_id=EG12029 EnsemblBacteria AAC75222 http://www.ensemblgenomes.org/id/AAC75222 EnsemblBacteria AAC75222 http://www.ensemblgenomes.org/id/AAC75222 EnsemblBacteria BAE76638 http://www.ensemblgenomes.org/id/BAE76638 EnsemblBacteria BAE76638 http://www.ensemblgenomes.org/id/BAE76638 EnsemblBacteria BAE76638 http://www.ensemblgenomes.org/id/BAE76638 EnsemblBacteria b2161 http://www.ensemblgenomes.org/id/b2161 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0005337 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005337 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GeneID 946655 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946655 HOGENOM HOG000267656 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267656&db=HOGENOM6 InParanoid P33021 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33021 IntAct P33021 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33021* InterPro IPR002668 http://www.ebi.ac.uk/interpro/entry/IPR002668 InterPro IPR008276 http://www.ebi.ac.uk/interpro/entry/IPR008276 InterPro IPR011657 http://www.ebi.ac.uk/interpro/entry/IPR011657 InterPro IPR018270 http://www.ebi.ac.uk/interpro/entry/IPR018270 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2148 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2148 KEGG_Gene eco:b2161 http://www.genome.jp/dbget-bin/www_bget?eco:b2161 KEGG_Orthology KO:K16325 http://www.genome.jp/dbget-bin/www_bget?KO:K16325 MINT MINT-1264070 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1264070 OMA SEICAIM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SEICAIM PANTHER PTHR10590 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10590 PSORT swissprot:NUPX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NUPX_ECOLI PSORT-B swissprot:NUPX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NUPX_ECOLI PSORT2 swissprot:NUPX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NUPX_ECOLI Pfam PF01773 http://pfam.xfam.org/family/PF01773 Pfam PF07662 http://pfam.xfam.org/family/PF07662 Phobius swissprot:NUPX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NUPX_ECOLI PhylomeDB P33021 http://phylomedb.org/?seqid=P33021 ProteinModelPortal P33021 http://www.proteinmodelportal.org/query/uniprot/P33021 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416666 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416666 RefSeq WP_000382966 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000382966 SMR P33021 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33021 STRING 511145.b2161 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2161&targetmode=cogs STRING COG1972 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1972&targetmode=cogs TCDB 2.A.41.2.10 http://www.tcdb.org/search/result.php?tc=2.A.41.2.10 TIGRFAMs TIGR00804 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00804 UniProtKB NUPX_ECOLI http://www.uniprot.org/uniprot/NUPX_ECOLI UniProtKB-AC P33021 http://www.uniprot.org/uniprot/P33021 charge swissprot:NUPX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NUPX_ECOLI eggNOG COG1972 http://eggnogapi.embl.de/nog_data/html/tree/COG1972 eggNOG ENOG4105D9N http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D9N epestfind swissprot:NUPX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NUPX_ECOLI garnier swissprot:NUPX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NUPX_ECOLI helixturnhelix swissprot:NUPX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NUPX_ECOLI hmoment swissprot:NUPX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NUPX_ECOLI iep swissprot:NUPX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NUPX_ECOLI inforesidue swissprot:NUPX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NUPX_ECOLI octanol swissprot:NUPX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NUPX_ECOLI pepcoil swissprot:NUPX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NUPX_ECOLI pepdigest swissprot:NUPX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NUPX_ECOLI pepinfo swissprot:NUPX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NUPX_ECOLI pepnet swissprot:NUPX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NUPX_ECOLI pepstats swissprot:NUPX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NUPX_ECOLI pepwheel swissprot:NUPX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NUPX_ECOLI pepwindow swissprot:NUPX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NUPX_ECOLI sigcleave swissprot:NUPX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NUPX_ECOLI ## Database ID URL or Descriptions # BioGrid 4261158 779 # EcoGene EG12767 agaS # FUNCTION AGAS_ECOLI May be a tagatose-6-phosphate ketose/aldose isomerase. {ECO 0000250}. # GO_function GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses; IEA:InterPro. # GO_function GO:0030246 carbohydrate binding; IEA:InterPro. # GO_process GO:0005975 carbohydrate metabolic process; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0005975 carbohydrate metabolic process # IntAct P42907 5 # InterPro IPR001347 SIS # InterPro IPR014180 Sugar_isomerase_AgaS # KEGG_Brite ko01000 Enzymes # MISCELLANEOUS AGAS_ECOLI In contrast to E.coli strains C and EC3132, K-12 strains cannot grow on N-acetylgalactosamine and D-galactosamine, because they carry a deletion and thus lack active PTS systems specific for these compounds. Therefore, AgaS in K-12 strains is not involved in the degradation of these compounds. # Organism AGAS_ECOLI Escherichia coli (strain K12) # PATRIC 32121690 VBIEscCol129921_3231 # PDB 3C3J X-ray; 1.80 A; A/B/C/D/E/F=1-384 # PIR D65103 D65103 # PROSITE PS51464 SIS; 2 # Pfam PF01380 SIS; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AGAS_ECOLI Putative tagatose-6-phosphate ketose/aldose isomerase # RefSeq NP_417605 NC_000913.3 # RefSeq WP_001114869 NZ_LN832404.1 # SIMILARITY Belongs to the SIS family. AgaS subfamily. {ECO 0000305}. # SIMILARITY Contains 2 SIS domains. {ECO:0000255|PROSITE- ProRule PRU00797}. # TIGRFAMs TIGR02815 agaS_fam # eggNOG COG2222 LUCA # eggNOG ENOG4105E70 Bacteria BLAST swissprot:AGAS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AGAS_ECOLI BioCyc ECOL316407:JW3105-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3105-MONOMER BioCyc EcoCyc:G7634-MONOMER http://biocyc.org/getid?id=EcoCyc:G7634-MONOMER COG COG2222 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2222 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1099/13500872-142-2-231 http://dx.doi.org/10.1099/13500872-142-2-231 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.3.1.- http://www.genome.jp/dbget-bin/www_bget?EC:5.3.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 5.3.1.- http://enzyme.expasy.org/EC/5.3.1.- EchoBASE EB2620 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2620 EcoGene EG12767 http://www.ecogene.org/geneInfo.php?eg_id=EG12767 EnsemblBacteria AAC76170 http://www.ensemblgenomes.org/id/AAC76170 EnsemblBacteria AAC76170 http://www.ensemblgenomes.org/id/AAC76170 EnsemblBacteria BAE77182 http://www.ensemblgenomes.org/id/BAE77182 EnsemblBacteria BAE77182 http://www.ensemblgenomes.org/id/BAE77182 EnsemblBacteria BAE77182 http://www.ensemblgenomes.org/id/BAE77182 EnsemblBacteria b3136 http://www.ensemblgenomes.org/id/b3136 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016861 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016861 GO_function GO:0030246 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030246 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GeneID 947645 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947645 HOGENOM HOG000272306 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000272306&db=HOGENOM6 InParanoid P42907 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P42907 IntAct P42907 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P42907* IntEnz 5.3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.3.1 InterPro IPR001347 http://www.ebi.ac.uk/interpro/entry/IPR001347 InterPro IPR014180 http://www.ebi.ac.uk/interpro/entry/IPR014180 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3105 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3105 KEGG_Gene eco:b3136 http://www.genome.jp/dbget-bin/www_bget?eco:b3136 KEGG_Orthology KO:K02082 http://www.genome.jp/dbget-bin/www_bget?KO:K02082 OMA YHLIITC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YHLIITC PDB 3C3J http://www.ebi.ac.uk/pdbe-srv/view/entry/3C3J PDBsum 3C3J http://www.ebi.ac.uk/pdbsum/3C3J PROSITE PS51464 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51464 PSORT swissprot:AGAS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AGAS_ECOLI PSORT-B swissprot:AGAS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AGAS_ECOLI PSORT2 swissprot:AGAS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AGAS_ECOLI Pfam PF01380 http://pfam.xfam.org/family/PF01380 Phobius swissprot:AGAS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AGAS_ECOLI PhylomeDB P42907 http://phylomedb.org/?seqid=P42907 ProteinModelPortal P42907 http://www.proteinmodelportal.org/query/uniprot/P42907 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8932697 http://www.ncbi.nlm.nih.gov/pubmed/8932697 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417605 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417605 RefSeq WP_001114869 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001114869 SMR P42907 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P42907 STRING 511145.b3136 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3136&targetmode=cogs STRING COG2222 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2222&targetmode=cogs TIGRFAMs TIGR02815 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02815 UniProtKB AGAS_ECOLI http://www.uniprot.org/uniprot/AGAS_ECOLI UniProtKB-AC P42907 http://www.uniprot.org/uniprot/P42907 charge swissprot:AGAS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AGAS_ECOLI eggNOG COG2222 http://eggnogapi.embl.de/nog_data/html/tree/COG2222 eggNOG ENOG4105E70 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E70 epestfind swissprot:AGAS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AGAS_ECOLI garnier swissprot:AGAS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AGAS_ECOLI helixturnhelix swissprot:AGAS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AGAS_ECOLI hmoment swissprot:AGAS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AGAS_ECOLI iep swissprot:AGAS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AGAS_ECOLI inforesidue swissprot:AGAS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AGAS_ECOLI octanol swissprot:AGAS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AGAS_ECOLI pepcoil swissprot:AGAS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AGAS_ECOLI pepdigest swissprot:AGAS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AGAS_ECOLI pepinfo swissprot:AGAS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AGAS_ECOLI pepnet swissprot:AGAS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AGAS_ECOLI pepstats swissprot:AGAS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AGAS_ECOLI pepwheel swissprot:AGAS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AGAS_ECOLI pepwindow swissprot:AGAS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AGAS_ECOLI sigcleave swissprot:AGAS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AGAS_ECOLI ## Database ID URL or Descriptions # CAUTION Could be the product of a pseudogene. This seems to be a remnant of a longer hydrolase gene that can be found in some other Escherichia and Shigella strains. {ECO 0000305}. # EcoGene EG14478 ymjD # INDUCTION In stationary phase (at protein level). {ECO:0000269|PubMed 19121005}. # Organism YMJD_ECOLI Escherichia coli (strain K12) # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YMJD_ECOLI Putative uncharacterized protein YmjD BLAST swissprot:YMJD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YMJD_ECOLI BioCyc EcoCyc:MONOMER0-2872 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2872 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2008.06495.x http://dx.doi.org/10.1111/j.1365-2958.2008.06495.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14478 http://www.ecogene.org/geneInfo.php?eg_id=EG14478 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv PSORT swissprot:YMJD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YMJD_ECOLI PSORT-B swissprot:YMJD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YMJD_ECOLI PSORT2 swissprot:YMJD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YMJD_ECOLI Phobius swissprot:YMJD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YMJD_ECOLI PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19121005 http://www.ncbi.nlm.nih.gov/pubmed/19121005 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 UniProtKB YMJD_ECOLI http://www.uniprot.org/uniprot/YMJD_ECOLI UniProtKB-AC P0CD93 http://www.uniprot.org/uniprot/P0CD93 charge swissprot:YMJD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YMJD_ECOLI epestfind swissprot:YMJD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YMJD_ECOLI garnier swissprot:YMJD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YMJD_ECOLI helixturnhelix swissprot:YMJD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YMJD_ECOLI hmoment swissprot:YMJD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YMJD_ECOLI iep swissprot:YMJD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YMJD_ECOLI inforesidue swissprot:YMJD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YMJD_ECOLI octanol swissprot:YMJD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YMJD_ECOLI pepcoil swissprot:YMJD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YMJD_ECOLI pepdigest swissprot:YMJD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YMJD_ECOLI pepinfo swissprot:YMJD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YMJD_ECOLI pepnet swissprot:YMJD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YMJD_ECOLI pepstats swissprot:YMJD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YMJD_ECOLI pepwheel swissprot:YMJD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YMJD_ECOLI pepwindow swissprot:YMJD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YMJD_ECOLI sigcleave swissprot:YMJD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YMJD_ECOLI ## Database ID URL or Descriptions # BioGrid 4260354 7 # EcoGene EG11136 yebB # InterPro IPR024453 Peptidase_C92 # Organism YEBB_ECOLI Escherichia coli (strain K12) # PATRIC 32119047 VBIEscCol129921_1941 # PIR F64948 F64948 # Pfam PF05708 Peptidase_C92 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEBB_ECOLI Uncharacterized protein YebB # RefSeq NP_416376 NC_000913.3 # RefSeq WP_001024932 NZ_LN832404.1 # SIMILARITY To E.coli YiiX. {ECO 0000305}. # eggNOG ENOG4107S01 Bacteria # eggNOG ENOG41115XM LUCA BLAST swissprot:YEBB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEBB_ECOLI BioCyc ECOL316407:JW5306-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5306-MONOMER BioCyc EcoCyc:EG11136-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11136-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D10165 http://www.ebi.ac.uk/ena/data/view/D10165 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X59551 http://www.ebi.ac.uk/ena/data/view/X59551 EchoBASE EB1126 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1126 EcoGene EG11136 http://www.ecogene.org/geneInfo.php?eg_id=EG11136 EnsemblBacteria AAC74932 http://www.ensemblgenomes.org/id/AAC74932 EnsemblBacteria AAC74932 http://www.ensemblgenomes.org/id/AAC74932 EnsemblBacteria BAA15673 http://www.ensemblgenomes.org/id/BAA15673 EnsemblBacteria BAA15673 http://www.ensemblgenomes.org/id/BAA15673 EnsemblBacteria BAA15673 http://www.ensemblgenomes.org/id/BAA15673 EnsemblBacteria b1862 http://www.ensemblgenomes.org/id/b1862 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946377 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946377 HOGENOM HOG000122724 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122724&db=HOGENOM6 InterPro IPR024453 http://www.ebi.ac.uk/interpro/entry/IPR024453 KEGG_Gene ecj:JW5306 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5306 KEGG_Gene eco:b1862 http://www.genome.jp/dbget-bin/www_bget?eco:b1862 OMA DNVNINY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DNVNINY PSORT swissprot:YEBB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEBB_ECOLI PSORT-B swissprot:YEBB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEBB_ECOLI PSORT2 swissprot:YEBB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEBB_ECOLI Pfam PF05708 http://pfam.xfam.org/family/PF05708 Phobius swissprot:YEBB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEBB_ECOLI PhylomeDB P24238 http://phylomedb.org/?seqid=P24238 ProteinModelPortal P24238 http://www.proteinmodelportal.org/query/uniprot/P24238 PubMed 1657895 http://www.ncbi.nlm.nih.gov/pubmed/1657895 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1885548 http://www.ncbi.nlm.nih.gov/pubmed/1885548 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416376 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416376 RefSeq WP_001024932 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001024932 SMR P24238 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P24238 STRING 511145.b1862 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1862&targetmode=cogs UniProtKB YEBB_ECOLI http://www.uniprot.org/uniprot/YEBB_ECOLI UniProtKB-AC P24238 http://www.uniprot.org/uniprot/P24238 charge swissprot:YEBB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEBB_ECOLI eggNOG ENOG4107S01 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107S01 eggNOG ENOG41115XM http://eggnogapi.embl.de/nog_data/html/tree/ENOG41115XM epestfind swissprot:YEBB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEBB_ECOLI garnier swissprot:YEBB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEBB_ECOLI helixturnhelix swissprot:YEBB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEBB_ECOLI hmoment swissprot:YEBB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEBB_ECOLI iep swissprot:YEBB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEBB_ECOLI inforesidue swissprot:YEBB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEBB_ECOLI octanol swissprot:YEBB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEBB_ECOLI pepcoil swissprot:YEBB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEBB_ECOLI pepdigest swissprot:YEBB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEBB_ECOLI pepinfo swissprot:YEBB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEBB_ECOLI pepnet swissprot:YEBB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEBB_ECOLI pepstats swissprot:YEBB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEBB_ECOLI pepwheel swissprot:YEBB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEBB_ECOLI pepwindow swissprot:YEBB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEBB_ECOLI sigcleave swissprot:YEBB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEBB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260547 14 # EcoGene EG14138 yfdP # IntAct P76512 4 # Organism YFDP_ECOLI Escherichia coli (strain K12) # PATRIC 32120095 VBIEscCol129921_2456 # PIR D65009 D65009 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFDP_ECOLI Uncharacterized protein YfdP # RefSeq NP_416860 NC_000913.3 # RefSeq WP_000135673 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAE76698.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY To phage T4 y06Q. {ECO 0000305}. # eggNOG ENOG4105H40 Bacteria # eggNOG ENOG4111T2F LUCA BLAST swissprot:YFDP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFDP_ECOLI BioCyc ECOL316407:JW2356-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2356-MONOMER BioCyc EcoCyc:G7228-MONOMER http://biocyc.org/getid?id=EcoCyc:G7228-MONOMER DIP DIP-12004N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12004N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14138 http://www.ecogene.org/geneInfo.php?eg_id=EG14138 EnsemblBacteria AAC75418 http://www.ensemblgenomes.org/id/AAC75418 EnsemblBacteria AAC75418 http://www.ensemblgenomes.org/id/AAC75418 EnsemblBacteria BAE76698 http://www.ensemblgenomes.org/id/BAE76698 EnsemblBacteria BAE76698 http://www.ensemblgenomes.org/id/BAE76698 EnsemblBacteria BAE76698 http://www.ensemblgenomes.org/id/BAE76698 EnsemblBacteria b2359 http://www.ensemblgenomes.org/id/b2359 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945565 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945565 HOGENOM HOG000123914 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000123914&db=HOGENOM6 IntAct P76512 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76512* KEGG_Gene ecj:JW2356 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2356 KEGG_Gene eco:b2359 http://www.genome.jp/dbget-bin/www_bget?eco:b2359 OMA MYVGKGG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MYVGKGG PSORT swissprot:YFDP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFDP_ECOLI PSORT-B swissprot:YFDP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFDP_ECOLI PSORT2 swissprot:YFDP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFDP_ECOLI Phobius swissprot:YFDP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFDP_ECOLI ProteinModelPortal P76512 http://www.proteinmodelportal.org/query/uniprot/P76512 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416860 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416860 RefSeq WP_000135673 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000135673 STRING 511145.b2359 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2359&targetmode=cogs UniProtKB YFDP_ECOLI http://www.uniprot.org/uniprot/YFDP_ECOLI UniProtKB-AC P76512 http://www.uniprot.org/uniprot/P76512 charge swissprot:YFDP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFDP_ECOLI eggNOG ENOG4105H40 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105H40 eggNOG ENOG4111T2F http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111T2F epestfind swissprot:YFDP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFDP_ECOLI garnier swissprot:YFDP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFDP_ECOLI helixturnhelix swissprot:YFDP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFDP_ECOLI hmoment swissprot:YFDP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFDP_ECOLI iep swissprot:YFDP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFDP_ECOLI inforesidue swissprot:YFDP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFDP_ECOLI octanol swissprot:YFDP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFDP_ECOLI pepcoil swissprot:YFDP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFDP_ECOLI pepdigest swissprot:YFDP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFDP_ECOLI pepinfo swissprot:YFDP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFDP_ECOLI pepnet swissprot:YFDP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFDP_ECOLI pepstats swissprot:YFDP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFDP_ECOLI pepwheel swissprot:YFDP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFDP_ECOLI pepwindow swissprot:YFDP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFDP_ECOLI sigcleave swissprot:YFDP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFDP_ECOLI ## Database ID URL or Descriptions # AltName Polyprenyl p-hydroxybenzoate decarboxylase {ECO:0000255|HAMAP-Rule MF_01636} # BioGrid 4261466 301 # CATALYTIC ACTIVITY UBID_ECOLI A 4-hydroxy-3-polyprenylbenzoate = a 2- polyprenylphenol + CO(2). {ECO 0000255|HAMAP-Rule MF_01636, ECO 0000269|PubMed 782527}. # COFACTOR UBID_ECOLI Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000255|HAMAP-Rule MF_01636, ECO 0000269|PubMed 782527}; Name=prenyl-FMN; Xref=ChEBI CHEBI 87746; Evidence={ECO 0000255|HAMAP-Rule MF_01636}; Note=Binds 1 prenylated FMN (prenyl-FMN) per subunit. {ECO 0000255|HAMAP-Rule MF_01636}; # ENZYME REGULATION Requires phospholipid, a metal ion, dithiothreitol and at least one other so far unidentified soluble cofactor for maximal activity. Inhibited by EDTA. {ECO:0000269|PubMed 782527}. # EcoGene EG11396 ubiD # FUNCTION UBID_ECOLI Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis. {ECO 0000255|HAMAP-Rule MF_01636, ECO 0000269|PubMed 782527}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_function GO:0008694 3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity; IDA:EcoCyc. # GO_function GO:0010181 FMN binding; IEA:InterPro. # GO_function GO:0016491 oxidoreductase activity; IEA:InterPro. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006744 ubiquinone biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # HAMAP MF_01636 UbiD # IntAct P0AAB4 4 # InterPro IPR002830 UbiD # InterPro IPR012349 Split_barrel_FMN-bd # InterPro IPR023677 UbiD_bacteria # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00130 Ubiquinone and other terpenoid-quinone biosynthesis # Organism UBID_ECOLI Escherichia coli (strain K12) # PATHWAY UBID_ECOLI Cofactor biosynthesis; ubiquinone biosynthesis. {ECO 0000255|HAMAP-Rule MF_01636, ECO 0000269|PubMed 782527}. # PATRIC 32123183 VBIEscCol129921_3957 # PDB 2IDB X-ray; 2.90 A; A/B/C=1-497 # PIR D65189 D65189 # PIR S20905 S20905 # PIR S30734 S30734 # Pfam PF01977 UbiD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 3-octaprenyl-4-hydroxybenzoate carboxy-lyase {ECO:0000255|HAMAP-Rule MF_01636} # RefSeq NP_418285 NC_000913.3 # RefSeq WP_000339804 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA67639.1; Type=Frameshift; Positions=380; Evidence={ECO:0000305}; Sequence=CAA46146.1; Type=Frameshift; Positions=376; Evidence={ECO 0000305}; # SIMILARITY Belongs to the UbiD family. {ECO:0000255|HAMAP- Rule MF_01636}. # SUBCELLULAR LOCATION UBID_ECOLI Cell membrane {ECO 0000255|HAMAP- Rule MF_01636, ECO 0000305|PubMed 782527}; Peripheral membrane protein {ECO 0000255|HAMAP-Rule MF_01636, ECO 0000305|PubMed 782527}. # SUBUNIT UBID_ECOLI Homohexamer. {ECO 0000255|HAMAP-Rule MF_01636, ECO 0000305|PubMed 782527, ECO 0000305|Ref.7}. # SUPFAM SSF50475 SSF50475 # TIGRFAMs TIGR00148 TIGR00148 # eggNOG COG0043 LUCA # eggNOG ENOG4105D3H Bacteria BLAST swissprot:UBID_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UBID_ECOLI BioCyc ECOL316407:JW3819-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3819-MONOMER BioCyc EcoCyc:EG11396-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11396-MONOMER BioCyc MetaCyc:EG11396-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11396-MONOMER COG COG0043 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0043 DIP DIP-48249N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48249N DOI 10.1016/0005-2736(76)90407-7 http://dx.doi.org/10.1016/0005-2736(76)90407-7 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1992.tb02166.x http://dx.doi.org/10.1111/j.1365-2958.1992.tb02166.x DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.21.6243-6246.2000 http://dx.doi.org/10.1128/JB.182.21.6243-6246.2000 EC_number EC:4.1.1.98 {ECO:0000255|HAMAP-Rule:MF_01636} http://www.genome.jp/dbget-bin/www_bget?EC:4.1.1.98 {ECO:0000255|HAMAP-Rule:MF_01636} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X65013 http://www.ebi.ac.uk/ena/data/view/X65013 ENZYME 4.1.1.98 {ECO:0000255|HAMAP-Rule:MF_01636} http://enzyme.expasy.org/EC/4.1.1.98 {ECO:0000255|HAMAP-Rule:MF_01636} EchoBASE EB1369 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1369 EcoGene EG11396 http://www.ecogene.org/geneInfo.php?eg_id=EG11396 EnsemblBacteria AAC76846 http://www.ensemblgenomes.org/id/AAC76846 EnsemblBacteria AAC76846 http://www.ensemblgenomes.org/id/AAC76846 EnsemblBacteria BAE77460 http://www.ensemblgenomes.org/id/BAE77460 EnsemblBacteria BAE77460 http://www.ensemblgenomes.org/id/BAE77460 EnsemblBacteria BAE77460 http://www.ensemblgenomes.org/id/BAE77460 EnsemblBacteria b3843 http://www.ensemblgenomes.org/id/b3843 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0008694 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008694 GO_function GO:0010181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010181 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006744 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006744 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GeneID 948326 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948326 HAMAP MF_01636 http://hamap.expasy.org/unirule/MF_01636 InParanoid P0AAB4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAB4 IntAct P0AAB4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAB4* IntEnz 4.1.1.98 {ECO:0000255|HAMAP-Rule:MF_01636} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.1.98 {ECO:0000255|HAMAP-Rule:MF_01636} InterPro IPR002830 http://www.ebi.ac.uk/interpro/entry/IPR002830 InterPro IPR012349 http://www.ebi.ac.uk/interpro/entry/IPR012349 InterPro IPR023677 http://www.ebi.ac.uk/interpro/entry/IPR023677 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3819 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3819 KEGG_Gene eco:b3843 http://www.genome.jp/dbget-bin/www_bget?eco:b3843 KEGG_Orthology KO:K03182 http://www.genome.jp/dbget-bin/www_bget?KO:K03182 KEGG_Pathway ko00130 http://www.genome.jp/kegg-bin/show_pathway?ko00130 KEGG_Reaction rn:R04985 http://www.genome.jp/dbget-bin/www_bget?rn:R04985 KEGG_Reaction rn:R04986 http://www.genome.jp/dbget-bin/www_bget?rn:R04986 OMA DFQEWCQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DFQEWCQ PDB 2IDB http://www.ebi.ac.uk/pdbe-srv/view/entry/2IDB PDBsum 2IDB http://www.ebi.ac.uk/pdbsum/2IDB PSORT swissprot:UBID_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UBID_ECOLI PSORT-B swissprot:UBID_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UBID_ECOLI PSORT2 swissprot:UBID_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UBID_ECOLI Pfam PF01977 http://pfam.xfam.org/family/PF01977 Phobius swissprot:UBID_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UBID_ECOLI PhylomeDB P0AAB4 http://phylomedb.org/?seqid=P0AAB4 ProteinModelPortal P0AAB4 http://www.proteinmodelportal.org/query/uniprot/P0AAB4 PubMed 11029449 http://www.ncbi.nlm.nih.gov/pubmed/11029449 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 1584020 http://www.ncbi.nlm.nih.gov/pubmed/1584020 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 782527 http://www.ncbi.nlm.nih.gov/pubmed/782527 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418285 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418285 RefSeq WP_000339804 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000339804 SMR P0AAB4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAB4 STRING 511145.b3843 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3843&targetmode=cogs STRING COG0043 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0043&targetmode=cogs SUPFAM SSF50475 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50475 TIGRFAMs TIGR00148 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00148 UniProtKB UBID_ECOLI http://www.uniprot.org/uniprot/UBID_ECOLI UniProtKB-AC P0AAB4 http://www.uniprot.org/uniprot/P0AAB4 charge swissprot:UBID_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UBID_ECOLI eggNOG COG0043 http://eggnogapi.embl.de/nog_data/html/tree/COG0043 eggNOG ENOG4105D3H http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D3H epestfind swissprot:UBID_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UBID_ECOLI garnier swissprot:UBID_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UBID_ECOLI helixturnhelix swissprot:UBID_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UBID_ECOLI hmoment swissprot:UBID_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UBID_ECOLI iep swissprot:UBID_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UBID_ECOLI inforesidue swissprot:UBID_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UBID_ECOLI octanol swissprot:UBID_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UBID_ECOLI pepcoil swissprot:UBID_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UBID_ECOLI pepdigest swissprot:UBID_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UBID_ECOLI pepinfo swissprot:UBID_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UBID_ECOLI pepnet swissprot:UBID_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UBID_ECOLI pepstats swissprot:UBID_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UBID_ECOLI pepwheel swissprot:UBID_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UBID_ECOLI pepwindow swissprot:UBID_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UBID_ECOLI sigcleave swissprot:UBID_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UBID_ECOLI ## Database ID URL or Descriptions # BioGrid 4260502 11 # EcoGene EG14097 yfbM # Gene3D 3.40.1760.10 -; 1. # IntAct P76483 5 # InterPro IPR015068 DUF1877 # Organism YFBM_ECOLI Escherichia coli (strain K12) # PATRIC 32119911 VBIEscCol129921_2365 # PDB 1RYL X-ray; 1.60 A; A/B=1-167 # PIR F64998 F64998 # Pfam PF08974 DUF1877 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFBM_ECOLI Protein YfbM # RefSeq NP_416775 NC_000913.3 # RefSeq WP_000525360 NZ_LN832404.1 # SUBUNIT Monomer. {ECO 0000269|Ref.3}. # SUPFAM SSF111069 SSF111069 # eggNOG ENOG4105GDX Bacteria # eggNOG ENOG4111J8J LUCA BLAST swissprot:YFBM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFBM_ECOLI BioCyc ECOL316407:JW2267-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2267-MONOMER BioCyc EcoCyc:G7179-MONOMER http://biocyc.org/getid?id=EcoCyc:G7179-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3850 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3850 EcoGene EG14097 http://www.ecogene.org/geneInfo.php?eg_id=EG14097 EnsemblBacteria AAC75332 http://www.ensemblgenomes.org/id/AAC75332 EnsemblBacteria AAC75332 http://www.ensemblgenomes.org/id/AAC75332 EnsemblBacteria BAE76680 http://www.ensemblgenomes.org/id/BAE76680 EnsemblBacteria BAE76680 http://www.ensemblgenomes.org/id/BAE76680 EnsemblBacteria BAE76680 http://www.ensemblgenomes.org/id/BAE76680 EnsemblBacteria b2272 http://www.ensemblgenomes.org/id/b2272 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.40.1760.10 http://www.cathdb.info/version/latest/superfamily/3.40.1760.10 GeneID 946745 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946745 HOGENOM HOG000122445 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122445&db=HOGENOM6 IntAct P76483 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76483* InterPro IPR015068 http://www.ebi.ac.uk/interpro/entry/IPR015068 KEGG_Gene ecj:JW2267 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2267 KEGG_Gene eco:b2272 http://www.genome.jp/dbget-bin/www_bget?eco:b2272 OMA PNIWDYE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PNIWDYE PDB 1RYL http://www.ebi.ac.uk/pdbe-srv/view/entry/1RYL PDBsum 1RYL http://www.ebi.ac.uk/pdbsum/1RYL PSORT swissprot:YFBM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFBM_ECOLI PSORT-B swissprot:YFBM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFBM_ECOLI PSORT2 swissprot:YFBM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFBM_ECOLI Pfam PF08974 http://pfam.xfam.org/family/PF08974 Phobius swissprot:YFBM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFBM_ECOLI ProteinModelPortal P76483 http://www.proteinmodelportal.org/query/uniprot/P76483 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416775 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416775 RefSeq WP_000525360 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000525360 SMR P76483 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76483 STRING 511145.b2272 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2272&targetmode=cogs SUPFAM SSF111069 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF111069 UniProtKB YFBM_ECOLI http://www.uniprot.org/uniprot/YFBM_ECOLI UniProtKB-AC P76483 http://www.uniprot.org/uniprot/P76483 charge swissprot:YFBM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFBM_ECOLI eggNOG ENOG4105GDX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105GDX eggNOG ENOG4111J8J http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111J8J epestfind swissprot:YFBM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFBM_ECOLI garnier swissprot:YFBM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFBM_ECOLI helixturnhelix swissprot:YFBM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFBM_ECOLI hmoment swissprot:YFBM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFBM_ECOLI iep swissprot:YFBM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFBM_ECOLI inforesidue swissprot:YFBM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFBM_ECOLI octanol swissprot:YFBM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFBM_ECOLI pepcoil swissprot:YFBM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFBM_ECOLI pepdigest swissprot:YFBM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFBM_ECOLI pepinfo swissprot:YFBM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFBM_ECOLI pepnet swissprot:YFBM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFBM_ECOLI pepstats swissprot:YFBM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFBM_ECOLI pepwheel swissprot:YFBM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFBM_ECOLI pepwindow swissprot:YFBM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFBM_ECOLI sigcleave swissprot:YFBM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFBM_ECOLI ## Database ID URL or Descriptions # BioGrid 4262207 10 # CDD cd01714 ETF_beta # EcoGene EG11562 fixA # FUNCTION FIXA_ECOLI Required for anaerobic carnitine reduction. May bring reductant to CaiA. {ECO 0000269|PubMed 12081978}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0009055 electron carrier activity; IBA:GO_Central. # GO_process GO:0009437 carnitine metabolic process; IMP:EcoliWiki. # GO_process GO:0055114 oxidation-reduction process; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0008150 biological_process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.50.620 -; 1. # HAMAP MF_01055 FixA # INTERACTION FIXA_ECOLI P0A9U1 ybhF; NbExp=3; IntAct=EBI-1113126, EBI-547696; # IntAct P60566 8 # InterPro IPR000049 ET-Flavoprotein_bsu_CS # InterPro IPR012255 ETF_b # InterPro IPR014729 Rossmann-like_a/b/a_fold # InterPro IPR014730 ETF_a/b_N # InterPro IPR023463 FixA # InterPro IPR033948 ETF_beta_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko00910 Nitrogen metabolism # Organism FIXA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21294 PTHR21294 # PATHWAY FIXA_ECOLI Amine and polyamine metabolism; carnitine metabolism. # PATRIC 32115181 VBIEscCol129921_0042 # PIR A64725 A64725 # PIRSF PIRSF000090 Beta-ETF # PROSITE PS01065 ETF_BETA # Pfam PF01012 ETF # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FIXA_ECOLI Protein FixA # RefSeq NP_414583 NC_000913.3 # RefSeq WP_000692204 NZ_LN832404.1 # SIMILARITY Belongs to the ETF beta-subunit/FixA family. {ECO 0000305}. # SMART SM00893 ETF # SUBUNIT Heterodimer of FixA and FixB. {ECO 0000305}. # eggNOG COG2086 LUCA # eggNOG ENOG4105BZJ Bacteria BLAST swissprot:FIXA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FIXA_ECOLI BioCyc ECOL316407:JW0040-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0040-MONOMER BioCyc EcoCyc:EG11562-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11562-MONOMER COG COG2086 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2086 DOI 10.1002/jobm.3620350404 http://dx.doi.org/10.1002/jobm.3620350404 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.14.4044-4047.2002 http://dx.doi.org/10.1128/JB.184.14.4044-4047.2002 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X71977 http://www.ebi.ac.uk/ena/data/view/X71977 EchoBASE EB1523 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1523 EcoGene EG11562 http://www.ecogene.org/geneInfo.php?eg_id=EG11562 EnsemblBacteria AAC73152 http://www.ensemblgenomes.org/id/AAC73152 EnsemblBacteria AAC73152 http://www.ensemblgenomes.org/id/AAC73152 EnsemblBacteria BAB96610 http://www.ensemblgenomes.org/id/BAB96610 EnsemblBacteria BAB96610 http://www.ensemblgenomes.org/id/BAB96610 EnsemblBacteria BAB96610 http://www.ensemblgenomes.org/id/BAB96610 EnsemblBacteria b0041 http://www.ensemblgenomes.org/id/b0041 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_process GO:0009437 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009437 GO_process GO:0055114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 GeneID 947316 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947316 HAMAP MF_01055 http://hamap.expasy.org/unirule/MF_01055 HOGENOM HOG000247880 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000247880&db=HOGENOM6 InParanoid P60566 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P60566 IntAct P60566 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P60566* InterPro IPR000049 http://www.ebi.ac.uk/interpro/entry/IPR000049 InterPro IPR012255 http://www.ebi.ac.uk/interpro/entry/IPR012255 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 InterPro IPR014730 http://www.ebi.ac.uk/interpro/entry/IPR014730 InterPro IPR023463 http://www.ebi.ac.uk/interpro/entry/IPR023463 InterPro IPR033948 http://www.ebi.ac.uk/interpro/entry/IPR033948 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW0040 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0040 KEGG_Gene eco:b0041 http://www.genome.jp/dbget-bin/www_bget?eco:b0041 KEGG_Orthology KO:K03521 http://www.genome.jp/dbget-bin/www_bget?KO:K03521 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 OMA CMGPPQA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CMGPPQA PANTHER PTHR21294 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21294 PROSITE PS01065 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01065 PSORT swissprot:FIXA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FIXA_ECOLI PSORT-B swissprot:FIXA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FIXA_ECOLI PSORT2 swissprot:FIXA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FIXA_ECOLI Pfam PF01012 http://pfam.xfam.org/family/PF01012 Phobius swissprot:FIXA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FIXA_ECOLI PhylomeDB P60566 http://phylomedb.org/?seqid=P60566 ProteinModelPortal P60566 http://www.proteinmodelportal.org/query/uniprot/P60566 PubMed 12081978 http://www.ncbi.nlm.nih.gov/pubmed/12081978 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7473063 http://www.ncbi.nlm.nih.gov/pubmed/7473063 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414583 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414583 RefSeq WP_000692204 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000692204 SMART SM00893 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00893 SMR P60566 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P60566 STRING 511145.b0041 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0041&targetmode=cogs STRING COG2086 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2086&targetmode=cogs UniProtKB FIXA_ECOLI http://www.uniprot.org/uniprot/FIXA_ECOLI UniProtKB-AC P60566 http://www.uniprot.org/uniprot/P60566 charge swissprot:FIXA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FIXA_ECOLI eggNOG COG2086 http://eggnogapi.embl.de/nog_data/html/tree/COG2086 eggNOG ENOG4105BZJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZJ epestfind swissprot:FIXA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FIXA_ECOLI garnier swissprot:FIXA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FIXA_ECOLI helixturnhelix swissprot:FIXA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FIXA_ECOLI hmoment swissprot:FIXA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FIXA_ECOLI iep swissprot:FIXA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FIXA_ECOLI inforesidue swissprot:FIXA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FIXA_ECOLI octanol swissprot:FIXA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FIXA_ECOLI pepcoil swissprot:FIXA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FIXA_ECOLI pepdigest swissprot:FIXA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FIXA_ECOLI pepinfo swissprot:FIXA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FIXA_ECOLI pepnet swissprot:FIXA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FIXA_ECOLI pepstats swissprot:FIXA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FIXA_ECOLI pepwheel swissprot:FIXA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FIXA_ECOLI pepwindow swissprot:FIXA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FIXA_ECOLI sigcleave swissprot:FIXA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FIXA_ECOLI ## Database ID URL or Descriptions # AltName LPMG_ECOLI Regulatory leader peptide for mgtA # EcoGene EG14498 mgtL # FUNCTION LPMG_ECOLI Makes mgtA transcription sensitive to intracellular proline levels. Under low levels of proline this protein cannot be fully translated, and a stem loop forms which permits transcription of the downstream mgtA gene (By similarity). {ECO 0000250}. # InterPro IPR031434 MGTL # Organism LPMG_ECOLI Escherichia coli (strain K12) # Pfam PF17059 MGTL # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LPMG_ECOLI MgtA leader peptide # RefSeq YP_003933616 NC_000913.3 # SIMILARITY Belongs to the mgtL family. {ECO 0000305}. BLAST swissprot:LPMG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LPMG_ECOLI BioCyc EcoCyc:MONOMER0-4201 http://biocyc.org/getid?id=EcoCyc:MONOMER0-4201 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14498 http://www.ecogene.org/geneInfo.php?eg_id=EG14498 EnsemblBacteria ADO17949 http://www.ensemblgenomes.org/id/ADO17949 EnsemblBacteria ADO17949 http://www.ensemblgenomes.org/id/ADO17949 EnsemblBacteria b4702 http://www.ensemblgenomes.org/id/b4702 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 9797237 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9797237 InterPro IPR031434 http://www.ebi.ac.uk/interpro/entry/IPR031434 KEGG_Gene eco:b4702 http://www.genome.jp/dbget-bin/www_bget?eco:b4702 PSORT swissprot:LPMG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LPMG_ECOLI PSORT-B swissprot:LPMG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LPMG_ECOLI PSORT2 swissprot:LPMG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LPMG_ECOLI Pfam PF17059 http://pfam.xfam.org/family/PF17059 Phobius swissprot:LPMG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LPMG_ECOLI PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq YP_003933616 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_003933616 STRING 511145.b4702 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4702&targetmode=cogs UniProtKB LPMG_ECOLI http://www.uniprot.org/uniprot/LPMG_ECOLI UniProtKB-AC E2JKY7 http://www.uniprot.org/uniprot/E2JKY7 charge swissprot:LPMG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LPMG_ECOLI epestfind swissprot:LPMG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LPMG_ECOLI garnier swissprot:LPMG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LPMG_ECOLI helixturnhelix swissprot:LPMG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LPMG_ECOLI hmoment swissprot:LPMG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LPMG_ECOLI iep swissprot:LPMG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LPMG_ECOLI inforesidue swissprot:LPMG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LPMG_ECOLI octanol swissprot:LPMG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LPMG_ECOLI pepcoil swissprot:LPMG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LPMG_ECOLI pepdigest swissprot:LPMG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LPMG_ECOLI pepinfo swissprot:LPMG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LPMG_ECOLI pepnet swissprot:LPMG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LPMG_ECOLI pepstats swissprot:LPMG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LPMG_ECOLI pepwheel swissprot:LPMG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LPMG_ECOLI pepwindow swissprot:LPMG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LPMG_ECOLI sigcleave swissprot:LPMG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LPMG_ECOLI ## Database ID URL or Descriptions # BioGrid 4261656 200 # CAUTION Was originally thought to be the site of the radC102 mutation, but it was subsequently shown that radC102 is an allele of RecG. {ECO:0000305|PubMed 11053371}. # CDD cd08071 MPN_DUF2466 # EcoGene EG11312 yicR # HAMAP MF_00018 UPF0758_YicR # IntAct P25531 2 # InterPro IPR001405 RadC # InterPro IPR010994 RuvA_2-like # InterPro IPR020891 UPF0758_CS # InterPro IPR022820 UPF0758_YicR # InterPro IPR025657 RadC_JAB # Organism YICR_ECOLI Escherichia coli (strain K12) # PATRIC 32122763 VBIEscCol129921_3758 # PIR H65164 H65164 # PROSITE PS01302 UPF0758 # Pfam PF04002 RadC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YICR_ECOLI UPF0758 protein YicR # RefSeq NP_418095 NC_000913.3 # RefSeq WP_001350561 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA61991.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the UPF0758 family. YicR subfamily. {ECO 0000305}. # SUPFAM SSF47781 SSF47781 # TIGRFAMs TIGR00608 radc # eggNOG COG2003 LUCA # eggNOG ENOG4105W5Q Bacteria BLAST swissprot:YICR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YICR_ECOLI BioCyc ECOL316407:JW5643-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5643-MONOMER BioCyc EcoCyc:EG11312-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11312-MONOMER COG COG2003 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2003 DIP DIP-10636N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10636N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/20.2.366 http://dx.doi.org/10.1093/nar/20.2.366 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.22.6287-6291.2000 http://dx.doi.org/10.1128/JB.182.22.6287-6291.2000 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X63366 http://www.ebi.ac.uk/ena/data/view/X63366 EMBL X63367 http://www.ebi.ac.uk/ena/data/view/X63367 EchoBASE EB1288 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1288 EcoGene EG11312 http://www.ecogene.org/geneInfo.php?eg_id=EG11312 EnsemblBacteria AAC76662 http://www.ensemblgenomes.org/id/AAC76662 EnsemblBacteria AAC76662 http://www.ensemblgenomes.org/id/AAC76662 EnsemblBacteria BAE77654 http://www.ensemblgenomes.org/id/BAE77654 EnsemblBacteria BAE77654 http://www.ensemblgenomes.org/id/BAE77654 EnsemblBacteria BAE77654 http://www.ensemblgenomes.org/id/BAE77654 EnsemblBacteria b3638 http://www.ensemblgenomes.org/id/b3638 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 948968 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948968 HAMAP MF_00018 http://hamap.expasy.org/unirule/MF_00018 HOGENOM HOG000273376 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000273376&db=HOGENOM6 InParanoid P25531 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P25531 IntAct P25531 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P25531* InterPro IPR001405 http://www.ebi.ac.uk/interpro/entry/IPR001405 InterPro IPR010994 http://www.ebi.ac.uk/interpro/entry/IPR010994 InterPro IPR020891 http://www.ebi.ac.uk/interpro/entry/IPR020891 InterPro IPR022820 http://www.ebi.ac.uk/interpro/entry/IPR022820 InterPro IPR025657 http://www.ebi.ac.uk/interpro/entry/IPR025657 KEGG_Gene ecj:JW5643 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5643 KEGG_Gene eco:b3638 http://www.genome.jp/dbget-bin/www_bget?eco:b3638 KEGG_Orthology KO:K03630 http://www.genome.jp/dbget-bin/www_bget?KO:K03630 MINT MINT-1313016 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1313016 OMA PHEEFWV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PHEEFWV PROSITE PS01302 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01302 PSORT swissprot:YICR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YICR_ECOLI PSORT-B swissprot:YICR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YICR_ECOLI PSORT2 swissprot:YICR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YICR_ECOLI Pfam PF04002 http://pfam.xfam.org/family/PF04002 Phobius swissprot:YICR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YICR_ECOLI PhylomeDB P25531 http://phylomedb.org/?seqid=P25531 ProteinModelPortal P25531 http://www.proteinmodelportal.org/query/uniprot/P25531 PubMed 11053371 http://www.ncbi.nlm.nih.gov/pubmed/11053371 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1741263 http://www.ncbi.nlm.nih.gov/pubmed/1741263 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418095 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418095 RefSeq WP_001350561 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001350561 SMR P25531 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P25531 STRING 511145.b3638 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3638&targetmode=cogs STRING COG2003 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2003&targetmode=cogs SUPFAM SSF47781 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47781 TIGRFAMs TIGR00608 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00608 UniProtKB YICR_ECOLI http://www.uniprot.org/uniprot/YICR_ECOLI UniProtKB-AC P25531 http://www.uniprot.org/uniprot/P25531 charge swissprot:YICR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YICR_ECOLI eggNOG COG2003 http://eggnogapi.embl.de/nog_data/html/tree/COG2003 eggNOG ENOG4105W5Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105W5Q epestfind swissprot:YICR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YICR_ECOLI garnier swissprot:YICR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YICR_ECOLI helixturnhelix swissprot:YICR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YICR_ECOLI hmoment swissprot:YICR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YICR_ECOLI iep swissprot:YICR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YICR_ECOLI inforesidue swissprot:YICR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YICR_ECOLI octanol swissprot:YICR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YICR_ECOLI pepcoil swissprot:YICR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YICR_ECOLI pepdigest swissprot:YICR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YICR_ECOLI pepinfo swissprot:YICR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YICR_ECOLI pepnet swissprot:YICR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YICR_ECOLI pepstats swissprot:YICR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YICR_ECOLI pepwheel swissprot:YICR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YICR_ECOLI pepwindow swissprot:YICR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YICR_ECOLI sigcleave swissprot:YICR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YICR_ECOLI ## Database ID URL or Descriptions # BioGrid 4259546 6 # DISRUPTION PHENOTYPE Cells lacking this gene fail to grow on the nucleobase uracil as the sole nitrogen source but use the nucleoside uridine normally. {ECO:0000269|PubMed 20400551}. # EcoGene EG13853 rutG # FUNCTION RUTG_ECOLI May function as a proton-driven pyrimidine uptake system. {ECO 0000269|PubMed 16540542}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_function GO:0015210 uracil transmembrane transporter activity; IMP:EcoCyc. # GO_function GO:0015218 pyrimidine nucleotide transmembrane transporter activity; IEA:InterPro. # GO_function GO:0015293 symporter activity; IEA:UniProtKB-KW. # GO_process GO:0006212 uracil catabolic process; IMP:EcoCyc. # GO_process GO:0015857 uracil transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # INDUCTION RUTG_ECOLI Up-regulated by the nitrogen regulatory protein C (NtrC also called GlnG) and repressed by RutR. {ECO 0000269|PubMed 11121068, ECO 0000269|PubMed 17919280}. # InterPro IPR006042 Xan_ur_permease # InterPro IPR006043 Xant/urac/vitC # InterPro IPR019918 Pyrimidine_permease_RutG_pred # KEGG_Brite ko02000 Transporters # MISCELLANEOUS RUTG_ECOLI The Rut pathway degrades exogenous pyrimidines as the sole nitrogen source at room temperature but not at 37 degrees Celsius, a restriction that is apparently a consequence of an inadequate ability to remove toxic malonic semialdehyde at the higher temperature (RutE/YdfG function). # Organism RUTG_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11119 PTHR11119 # PATRIC 32117241 VBIEscCol129921_1044 # PIR D64842 D64842 # PROSITE PS01116 XANTH_URACIL_PERMASE # Pfam PF00860 Xan_ur_permease # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RUTG_ECOLI Putative pyrimidine permease RutG # RefSeq NP_415526 NC_000913.3 # RefSeq WP_001326838 NZ_LN832404.1 # SIMILARITY Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION RUTG_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.40.1:the nucleobase/ascorbate transporter (nat) or nucleobase cation symporter-2 (ncs2) family # TIGRFAMs TIGR00801 ncs2 # TIGRFAMs TIGR03616 RutG # eggNOG COG2233 LUCA # eggNOG ENOG4105C2W Bacteria BLAST swissprot:RUTG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RUTG_ECOLI BioCyc ECOL316407:JW5137-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5137-MONOMER BioCyc EcoCyc:B1006-MONOMER http://biocyc.org/getid?id=EcoCyc:B1006-MONOMER BioCyc MetaCyc:B1006-MONOMER http://biocyc.org/getid?id=MetaCyc:B1006-MONOMER COG COG2233 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2233 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0600521103 http://dx.doi.org/10.1073/pnas.0600521103 DOI 10.1073/pnas.97.26.14674 http://dx.doi.org/10.1073/pnas.97.26.14674 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.2007.05954.x http://dx.doi.org/10.1111/j.1365-2958.2007.05954.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00201-10 http://dx.doi.org/10.1128/JB.00201-10 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3613 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3613 EcoGene EG13853 http://www.ecogene.org/geneInfo.php?eg_id=EG13853 EnsemblBacteria AAC74091 http://www.ensemblgenomes.org/id/AAC74091 EnsemblBacteria AAC74091 http://www.ensemblgenomes.org/id/AAC74091 EnsemblBacteria BAA35773 http://www.ensemblgenomes.org/id/BAA35773 EnsemblBacteria BAA35773 http://www.ensemblgenomes.org/id/BAA35773 EnsemblBacteria BAA35773 http://www.ensemblgenomes.org/id/BAA35773 EnsemblBacteria b1006 http://www.ensemblgenomes.org/id/b1006 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015210 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015210 GO_function GO:0015218 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015218 GO_function GO:0015293 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293 GO_process GO:0006212 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006212 GO_process GO:0015857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015857 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 946589 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946589 HOGENOM HOG000038200 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000038200&db=HOGENOM6 InParanoid P75892 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75892 InterPro IPR006042 http://www.ebi.ac.uk/interpro/entry/IPR006042 InterPro IPR006043 http://www.ebi.ac.uk/interpro/entry/IPR006043 InterPro IPR019918 http://www.ebi.ac.uk/interpro/entry/IPR019918 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5137 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5137 KEGG_Gene eco:b1006 http://www.genome.jp/dbget-bin/www_bget?eco:b1006 KEGG_Orthology KO:K09016 http://www.genome.jp/dbget-bin/www_bget?KO:K09016 OMA RLTWTRT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RLTWTRT PANTHER PTHR11119 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11119 PROSITE PS01116 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01116 PSORT swissprot:RUTG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RUTG_ECOLI PSORT-B swissprot:RUTG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RUTG_ECOLI PSORT2 swissprot:RUTG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RUTG_ECOLI Pfam PF00860 http://pfam.xfam.org/family/PF00860 Phobius swissprot:RUTG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RUTG_ECOLI PhylomeDB P75892 http://phylomedb.org/?seqid=P75892 ProteinModelPortal P75892 http://www.proteinmodelportal.org/query/uniprot/P75892 PubMed 11121068 http://www.ncbi.nlm.nih.gov/pubmed/11121068 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16540542 http://www.ncbi.nlm.nih.gov/pubmed/16540542 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17919280 http://www.ncbi.nlm.nih.gov/pubmed/17919280 PubMed 20400551 http://www.ncbi.nlm.nih.gov/pubmed/20400551 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415526 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415526 RefSeq WP_001326838 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001326838 STRING 511145.b1006 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1006&targetmode=cogs STRING COG2233 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2233&targetmode=cogs TCDB 2.A.40.1 http://www.tcdb.org/search/result.php?tc=2.A.40.1 TIGRFAMs TIGR00801 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00801 TIGRFAMs TIGR03616 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03616 UniProtKB RUTG_ECOLI http://www.uniprot.org/uniprot/RUTG_ECOLI UniProtKB-AC P75892 http://www.uniprot.org/uniprot/P75892 charge swissprot:RUTG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RUTG_ECOLI eggNOG COG2233 http://eggnogapi.embl.de/nog_data/html/tree/COG2233 eggNOG ENOG4105C2W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C2W epestfind swissprot:RUTG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RUTG_ECOLI garnier swissprot:RUTG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RUTG_ECOLI helixturnhelix swissprot:RUTG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RUTG_ECOLI hmoment swissprot:RUTG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RUTG_ECOLI iep swissprot:RUTG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RUTG_ECOLI inforesidue swissprot:RUTG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RUTG_ECOLI octanol swissprot:RUTG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RUTG_ECOLI pepcoil swissprot:RUTG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RUTG_ECOLI pepdigest swissprot:RUTG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RUTG_ECOLI pepinfo swissprot:RUTG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RUTG_ECOLI pepnet swissprot:RUTG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RUTG_ECOLI pepstats swissprot:RUTG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RUTG_ECOLI pepwheel swissprot:RUTG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RUTG_ECOLI pepwindow swissprot:RUTG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RUTG_ECOLI sigcleave swissprot:RUTG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RUTG_ECOLI ## Database ID URL or Descriptions # AltName ZAPA_ECOLI Z ring-associated protein ZapA # BioGrid 4262169 354 # EcoGene EG12878 zapA # FUNCTION ZAPA_ECOLI Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division. {ECO 0000269|PubMed 15060045}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-HAMAP. # GO_component GO:0030428 cell septum; IMP:EcoliWiki. # GO_component GO:0032153 cell division site; IDA:EcoliWiki. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0000917 barrier septum assembly; IMP:EcoliWiki. # GO_process GO:0000921 septin ring assembly; IDA:EcoliWiki. # GO_process GO:0043093 FtsZ-dependent cytokinesis; IMP:EcoCyc. # GO_process GO:0051301 cell division; IMP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0007010 cytoskeleton organization # GOslim_process GO:0008150 biological_process # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0051301 cell division # HAMAP MF_02012 ZapA_type1 # INTERACTION ZAPA_ECOLI P0AF36 zapB; NbExp=4; IntAct=EBI-1119901, EBI-1134093; # IntAct P0ADS2 8 # InterPro IPR007838 Cell_div_ZapA-like # InterPro IPR023771 Cell_div_ZapA_eubact # KEGG_Brite ko03036 Chromosome # Organism ZAPA_ECOLI Escherichia coli (strain K12) # PATRIC 32121234 VBIEscCol129921_3005 # PDB 4P1M X-ray; 1.95 A; A/B=1-109 # PIR F65075 F65075 # Pfam PF05164 ZapA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ZAPA_ECOLI Cell division protein ZapA # RefSeq NP_417386 NC_000913.3 # RefSeq WP_001276008 NZ_LN832404.1 # SIMILARITY Belongs to the ZapA family. Type 1 subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION ZAPA_ECOLI Cytoplasm {ECO 0000269|PubMed 12368265}. Note=Localizes at mid-cell. # SUBUNIT ZAPA_ECOLI Homodimer. Interacts with FtsZ. {ECO 0000269|PubMed 15317782, ECO 0000269|PubMed 17428494}. # SUPFAM SSF102829 SSF102829 # eggNOG COG3027 LUCA # eggNOG ENOG4107YUN Bacteria BLAST swissprot:ZAPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ZAPA_ECOLI BioCyc ECOL316407:JW2878-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2878-MONOMER BioCyc EcoCyc:EG12878-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12878-MONOMER COG COG3027 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3027 DOI 10.1016/j.jmb.2007.03.025 http://dx.doi.org/10.1016/j.jmb.2007.03.025 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1101/gad.1014102 http://dx.doi.org/10.1101/gad.1014102 DOI 10.1101/gad.1253805 http://dx.doi.org/10.1101/gad.1253805 DOI 10.1107/S1744309105003945 http://dx.doi.org/10.1107/S1744309105003945 DOI 10.1111/j.1365-2958.2005.04502.x http://dx.doi.org/10.1111/j.1365-2958.2005.04502.x DOI 10.1111/j.1365-2958.2006.05206.x http://dx.doi.org/10.1111/j.1365-2958.2006.05206.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.186.17.5775-5781.2004 http://dx.doi.org/10.1128/JB.186.17.5775-5781.2004 DOI 10.1128/JB.186.8.2418-2429.2004 http://dx.doi.org/10.1128/JB.186.8.2418-2429.2004 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D90281 http://www.ebi.ac.uk/ena/data/view/D90281 EMBL M12965 http://www.ebi.ac.uk/ena/data/view/M12965 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2716 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2716 EcoGene EG12878 http://www.ecogene.org/geneInfo.php?eg_id=EG12878 EnsemblBacteria AAC75948 http://www.ensemblgenomes.org/id/AAC75948 EnsemblBacteria AAC75948 http://www.ensemblgenomes.org/id/AAC75948 EnsemblBacteria BAE76975 http://www.ensemblgenomes.org/id/BAE76975 EnsemblBacteria BAE76975 http://www.ensemblgenomes.org/id/BAE76975 EnsemblBacteria BAE76975 http://www.ensemblgenomes.org/id/BAE76975 EnsemblBacteria b2910 http://www.ensemblgenomes.org/id/b2910 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0030428 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030428 GO_component GO:0032153 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032153 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0000917 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000917 GO_process GO:0000921 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000921 GO_process GO:0043093 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043093 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0007010 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007010 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GeneID 947404 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947404 HAMAP MF_02012 http://hamap.expasy.org/unirule/MF_02012 HOGENOM HOG000263522 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000263522&db=HOGENOM6 InParanoid P0ADS2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADS2 IntAct P0ADS2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADS2* InterPro IPR007838 http://www.ebi.ac.uk/interpro/entry/IPR007838 InterPro IPR023771 http://www.ebi.ac.uk/interpro/entry/IPR023771 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene ecj:JW2878 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2878 KEGG_Gene eco:b2910 http://www.genome.jp/dbget-bin/www_bget?eco:b2910 KEGG_Orthology KO:K09888 http://www.genome.jp/dbget-bin/www_bget?KO:K09888 OMA NICYELH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NICYELH PDB 4P1M http://www.ebi.ac.uk/pdbe-srv/view/entry/4P1M PDBsum 4P1M http://www.ebi.ac.uk/pdbsum/4P1M PSORT swissprot:ZAPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ZAPA_ECOLI PSORT-B swissprot:ZAPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ZAPA_ECOLI PSORT2 swissprot:ZAPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ZAPA_ECOLI Pfam PF05164 http://pfam.xfam.org/family/PF05164 Phobius swissprot:ZAPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ZAPA_ECOLI PhylomeDB P0ADS2 http://phylomedb.org/?seqid=P0ADS2 ProteinModelPortal P0ADS2 http://www.proteinmodelportal.org/query/uniprot/P0ADS2 PubMed 12368265 http://www.ncbi.nlm.nih.gov/pubmed/12368265 PubMed 1339425 http://www.ncbi.nlm.nih.gov/pubmed/1339425 PubMed 15060045 http://www.ncbi.nlm.nih.gov/pubmed/15060045 PubMed 15317782 http://www.ncbi.nlm.nih.gov/pubmed/15317782 PubMed 15630023 http://www.ncbi.nlm.nih.gov/pubmed/15630023 PubMed 15752189 http://www.ncbi.nlm.nih.gov/pubmed/15752189 PubMed 16511026 http://www.ncbi.nlm.nih.gov/pubmed/16511026 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16824093 http://www.ncbi.nlm.nih.gov/pubmed/16824093 PubMed 17428494 http://www.ncbi.nlm.nih.gov/pubmed/17428494 PubMed 2579060 http://www.ncbi.nlm.nih.gov/pubmed/2579060 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417386 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417386 RefSeq WP_001276008 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001276008 SMR P0ADS2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADS2 STRING 511145.b2910 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2910&targetmode=cogs STRING COG3027 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3027&targetmode=cogs SUPFAM SSF102829 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF102829 UniProtKB ZAPA_ECOLI http://www.uniprot.org/uniprot/ZAPA_ECOLI UniProtKB-AC P0ADS2 http://www.uniprot.org/uniprot/P0ADS2 charge swissprot:ZAPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ZAPA_ECOLI eggNOG COG3027 http://eggnogapi.embl.de/nog_data/html/tree/COG3027 eggNOG ENOG4107YUN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107YUN epestfind swissprot:ZAPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ZAPA_ECOLI garnier swissprot:ZAPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ZAPA_ECOLI helixturnhelix swissprot:ZAPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ZAPA_ECOLI hmoment swissprot:ZAPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ZAPA_ECOLI iep swissprot:ZAPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ZAPA_ECOLI inforesidue swissprot:ZAPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ZAPA_ECOLI octanol swissprot:ZAPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ZAPA_ECOLI pepcoil swissprot:ZAPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ZAPA_ECOLI pepdigest swissprot:ZAPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ZAPA_ECOLI pepinfo swissprot:ZAPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ZAPA_ECOLI pepnet swissprot:ZAPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ZAPA_ECOLI pepstats swissprot:ZAPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ZAPA_ECOLI pepwheel swissprot:ZAPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ZAPA_ECOLI pepwindow swissprot:ZAPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ZAPA_ECOLI sigcleave swissprot:ZAPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ZAPA_ECOLI ## Database ID URL or Descriptions # AltName Fructose-like phosphotransferase enzyme IIB component 2 {ECO:0000250|UniProtKB P20966} # BioGrid 4262059 13 # CATALYTIC ACTIVITY [Protein]-N(pi)-phospho-L-histidine + D- fructose(Side 1) = [protein]-L-histidine + D-fructose 1- phosphate(Side 2). {ECO:0000250|UniProtKB P20966}. # CDD cd05569 PTS_IIB_fructose # DOMAIN PTFB2_ECOLI The PTS EIIB type-2 domain is phosphorylated by phospho- EIIA on a cysteinyl residue. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the PTS EIIC type-2 domain. {ECO 0000255|PROSITE- ProRule PRU00422}. # EcoGene EG11909 frwB # FUNCTION PTFB2_ECOLI The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FrwABC PTS system is involved in fructose transport. {ECO 0000250|UniProtKB P20966, ECO 0000305|PubMed 7773398}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0016301 kinase activity; IEA:UniProtKB-KW. # GO_function GO:0022877 protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity; IEA:InterPro. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # IntAct P69816 4 # InterPro IPR003353 PTS_IIB_fruc # InterPro IPR003501 PTS_EIIB_2/3 # InterPro IPR013011 PTS_EIIB_2 # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00306 PTS system, fructose-specific II-like component # KEGG_Brite ko02000 Transporters # Organism PTFB2_ECOLI Escherichia coli (strain K12) # PATRIC 32123421 VBIEscCol129921_4071 # PIR A65202 A65202 # PROSITE PS51099 PTS_EIIB_TYPE_2 # Pfam PF02302 PTS_IIB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PTS system fructose-like EIIB component 2 {ECO:0000250|UniProtKB P20966} # RefSeq NP_418385 NC_000913.3 # RefSeq WP_000161265 NZ_LN832404.1 # SIMILARITY Contains 1 PTS EIIB type-2 domain. {ECO:0000255|PROSITE-ProRule PRU00422}. # SUBCELLULAR LOCATION PTFB2_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF52794 SSF52794 # TCDB 4.A.2.1.10 the pts fructose-mannitol (fru) family # TIGRFAMs TIGR00829 FRU # eggNOG COG1445 LUCA # eggNOG ENOG4108YRF Bacteria BLAST swissprot:PTFB2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTFB2_ECOLI BioCyc ECOL316407:JW3922-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3922-MONOMER BioCyc EcoCyc:FRWB-MONOMER http://biocyc.org/getid?id=EcoCyc:FRWB-MONOMER BioCyc MetaCyc:FRWB-MONOMER http://biocyc.org/getid?id=MetaCyc:FRWB-MONOMER COG COG1445 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1445 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1099/13500872-141-4-961 http://dx.doi.org/10.1099/13500872-141-4-961 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.202 {ECO:0000250|UniProtKB:P20966} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.202 {ECO:0000250|UniProtKB:P20966} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.202 {ECO:0000250|UniProtKB:P20966} http://enzyme.expasy.org/EC/2.7.1.202 {ECO:0000250|UniProtKB:P20966} EchoBASE EB1853 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1853 EcoGene EG11909 http://www.ecogene.org/geneInfo.php?eg_id=EG11909 EnsemblBacteria AAC76932 http://www.ensemblgenomes.org/id/AAC76932 EnsemblBacteria AAC76932 http://www.ensemblgenomes.org/id/AAC76932 EnsemblBacteria BAE77361 http://www.ensemblgenomes.org/id/BAE77361 EnsemblBacteria BAE77361 http://www.ensemblgenomes.org/id/BAE77361 EnsemblBacteria BAE77361 http://www.ensemblgenomes.org/id/BAE77361 EnsemblBacteria b3950 http://www.ensemblgenomes.org/id/b3950 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_function GO:0022877 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022877 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948447 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948447 HOGENOM HOG000231313 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231313&db=HOGENOM6 IntAct P69816 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69816* IntEnz 2.7.1.202 {ECO:0000250|UniProtKB:P20966} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.202 {ECO:0000250|UniProtKB:P20966} InterPro IPR003353 http://www.ebi.ac.uk/interpro/entry/IPR003353 InterPro IPR003501 http://www.ebi.ac.uk/interpro/entry/IPR003501 InterPro IPR013011 http://www.ebi.ac.uk/interpro/entry/IPR013011 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3922 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3922 KEGG_Gene eco:b3950 http://www.genome.jp/dbget-bin/www_bget?eco:b3950 KEGG_Orthology KO:K11202 http://www.genome.jp/dbget-bin/www_bget?KO:K11202 OMA GAMGMID http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GAMGMID PROSITE PS51099 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51099 PSORT swissprot:PTFB2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTFB2_ECOLI PSORT-B swissprot:PTFB2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTFB2_ECOLI PSORT2 swissprot:PTFB2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTFB2_ECOLI Pfam PF02302 http://pfam.xfam.org/family/PF02302 Phobius swissprot:PTFB2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTFB2_ECOLI PhylomeDB P69816 http://phylomedb.org/?seqid=P69816 ProteinModelPortal P69816 http://www.proteinmodelportal.org/query/uniprot/P69816 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7773398 http://www.ncbi.nlm.nih.gov/pubmed/7773398 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418385 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418385 RefSeq WP_000161265 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000161265 SMR P69816 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69816 STRING 511145.b3950 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3950&targetmode=cogs STRING COG1445 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1445&targetmode=cogs SUPFAM SSF52794 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52794 TCDB 4.A.2.1.10 http://www.tcdb.org/search/result.php?tc=4.A.2.1.10 TIGRFAMs TIGR00829 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00829 UniProtKB PTFB2_ECOLI http://www.uniprot.org/uniprot/PTFB2_ECOLI UniProtKB-AC P69816 http://www.uniprot.org/uniprot/P69816 charge swissprot:PTFB2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTFB2_ECOLI eggNOG COG1445 http://eggnogapi.embl.de/nog_data/html/tree/COG1445 eggNOG ENOG4108YRF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108YRF epestfind swissprot:PTFB2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTFB2_ECOLI garnier swissprot:PTFB2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTFB2_ECOLI helixturnhelix swissprot:PTFB2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTFB2_ECOLI hmoment swissprot:PTFB2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTFB2_ECOLI iep swissprot:PTFB2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTFB2_ECOLI inforesidue swissprot:PTFB2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTFB2_ECOLI octanol swissprot:PTFB2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTFB2_ECOLI pepcoil swissprot:PTFB2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTFB2_ECOLI pepdigest swissprot:PTFB2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTFB2_ECOLI pepinfo swissprot:PTFB2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTFB2_ECOLI pepnet swissprot:PTFB2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTFB2_ECOLI pepstats swissprot:PTFB2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTFB2_ECOLI pepwheel swissprot:PTFB2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTFB2_ECOLI pepwindow swissprot:PTFB2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTFB2_ECOLI sigcleave swissprot:PTFB2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTFB2_ECOLI ## Database ID URL or Descriptions # BioGrid 4261285 126 # EcoGene EG13248 ybaT # FUNCTION YBAT_ECOLI Probable amino-acid or metabolite transport protein. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0015179 L-amino acid transmembrane transporter activity; IBA:GO_Central. # GO_function GO:0015297 antiporter activity; IBA:GO_Central. # GO_process GO:0009268 response to pH; IEP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0008150 biological_process # InterPro IPR002293 AA/rel_permease1 # Organism YBAT_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11785 PTHR11785 # PATRIC 32116131 VBIEscCol129921_0507 # PIR E64779 E64779 # PIRSF PIRSF006060 AA_transporter # Pfam PF13520 AA_permease_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBAT_ECOLI Inner membrane transport protein YbaT # RefSeq NP_415019 NC_000913.3 # RefSeq WP_000982172 NZ_LN832404.1 # SIMILARITY Belongs to the amino acid-polyamine-organocation (APC) superfamily. {ECO 0000305}. # SUBCELLULAR LOCATION YBAT_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.3.6 the amino acid-polyamine-organocation (apc) family # eggNOG COG0531 LUCA # eggNOG ENOG4107RY6 Bacteria BLAST swissprot:YBAT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBAT_ECOLI BioCyc ECOL316407:JW0475-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0475-MONOMER BioCyc EcoCyc:B0486-MONOMER http://biocyc.org/getid?id=EcoCyc:B0486-MONOMER DIP DIP-11308N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11308N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EchoBASE EB3037 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3037 EcoGene EG13248 http://www.ecogene.org/geneInfo.php?eg_id=EG13248 EnsemblBacteria AAC73588 http://www.ensemblgenomes.org/id/AAC73588 EnsemblBacteria AAC73588 http://www.ensemblgenomes.org/id/AAC73588 EnsemblBacteria BAE76265 http://www.ensemblgenomes.org/id/BAE76265 EnsemblBacteria BAE76265 http://www.ensemblgenomes.org/id/BAE76265 EnsemblBacteria BAE76265 http://www.ensemblgenomes.org/id/BAE76265 EnsemblBacteria b0486 http://www.ensemblgenomes.org/id/b0486 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015179 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015179 GO_function GO:0015297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015297 GO_process GO:0009268 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009268 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 945363 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945363 HOGENOM HOG000050034 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000050034&db=HOGENOM6 InParanoid P77400 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77400 IntAct P77400 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77400* InterPro IPR002293 http://www.ebi.ac.uk/interpro/entry/IPR002293 KEGG_Gene ecj:JW0475 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0475 KEGG_Gene eco:b0486 http://www.genome.jp/dbget-bin/www_bget?eco:b0486 MINT MINT-1267628 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1267628 OMA HAFGAYA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HAFGAYA PANTHER PTHR11785 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11785 PSORT swissprot:YBAT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBAT_ECOLI PSORT-B swissprot:YBAT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBAT_ECOLI PSORT2 swissprot:YBAT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBAT_ECOLI Pfam PF13520 http://pfam.xfam.org/family/PF13520 Phobius swissprot:YBAT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBAT_ECOLI PhylomeDB P77400 http://phylomedb.org/?seqid=P77400 ProteinModelPortal P77400 http://www.proteinmodelportal.org/query/uniprot/P77400 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415019 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415019 RefSeq WP_000982172 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000982172 STRING 511145.b0486 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0486&targetmode=cogs TCDB 2.A.3.6 http://www.tcdb.org/search/result.php?tc=2.A.3.6 UniProtKB YBAT_ECOLI http://www.uniprot.org/uniprot/YBAT_ECOLI UniProtKB-AC P77400 http://www.uniprot.org/uniprot/P77400 charge swissprot:YBAT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBAT_ECOLI eggNOG COG0531 http://eggnogapi.embl.de/nog_data/html/tree/COG0531 eggNOG ENOG4107RY6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107RY6 epestfind swissprot:YBAT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBAT_ECOLI garnier swissprot:YBAT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBAT_ECOLI helixturnhelix swissprot:YBAT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBAT_ECOLI hmoment swissprot:YBAT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBAT_ECOLI iep swissprot:YBAT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBAT_ECOLI inforesidue swissprot:YBAT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBAT_ECOLI octanol swissprot:YBAT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBAT_ECOLI pepcoil swissprot:YBAT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBAT_ECOLI pepdigest swissprot:YBAT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBAT_ECOLI pepinfo swissprot:YBAT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBAT_ECOLI pepnet swissprot:YBAT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBAT_ECOLI pepstats swissprot:YBAT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBAT_ECOLI pepwheel swissprot:YBAT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBAT_ECOLI pepwindow swissprot:YBAT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBAT_ECOLI sigcleave swissprot:YBAT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBAT_ECOLI ## Database ID URL or Descriptions # AltName G-protein chaperone {ECO 0000305} # BioGrid 4259325 10 # CATALYTIC ACTIVITY GTP + H(2)O = GDP + phosphate. {ECO:0000269|PubMed 18950999}. # CAUTION Was originally thought to be a membrane protein kinase involved in phosphorylation of the AO and LAO periplasmic-binding proteins (PubMed:9733684). However, its role needs to be reexamined. {ECO 0000305|PubMed:9733684}. # EcoGene EG11445 argK # FUNCTION ARGK_ECOLI Binds and hydrolyzes GTP (PubMed 18950999). Likely functions as a G-protein chaperone that assists AdoCbl cofactor delivery to the methylmalonyl-CoA mutase (MCM) ScpA and reactivation of the enzyme during catalysis. {ECO 0000269|PubMed 18950999, ECO 0000305}. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_function GO:0000155 phosphorelay sensor kinase activity; IEA:InterPro. # GO_function GO:0003924 GTPase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0005525 GTP binding; IEA:UniProtKB-KW. # GOslim_component GO:0005622 intracellular # GOslim_function GO:0003924 GTPase activity # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # Gene3D 1.10.287.130 -; 1. # Gene3D 3.40.50.300 -; 1. # IntAct P27254 13 # InterPro IPR003661 HisK_dim/P # InterPro IPR005129 GTPase_ArgK # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko01000 Enzymes # MISCELLANEOUS Part of an operon that encodes enzymes converting succinate to propionate. {ECO:0000305|PubMed 18950999}. # Organism ARGK_ECOLI Escherichia coli (strain K12) # PATRIC 32121250 VBIEscCol129921_3013 # PDB 2P67 X-ray; 1.80 A; A=2-331 # PIR E65076 E65076 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GTPase ArgK {ECO:0000305|PubMed 18950999} # RefSeq NP_417393 NC_000913.3 # RefSeq WP_000606525 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA47312.1; Type=Frameshift; Positions=Several; Evidence={ECO 0000305}; # SIMILARITY Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily. {ECO 0000305}. # SUBUNIT Monomer. Interacts with the methylmalonyl-CoA mutase ScpA. {ECO:0000269|PubMed 18950999}. # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR00750 lao # eggNOG COG1703 LUCA # eggNOG ENOG4105DJT Bacteria BLAST swissprot:ARGK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARGK_ECOLI BioCyc ECOL316407:JW2885-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2885-MONOMER BioCyc EcoCyc:EG11445-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11445-MONOMER BioCyc MetaCyc:EG11445-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11445-MONOMER COG COG1703 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1703 DOI 10.1016/j.micres.2008.08.006 http://dx.doi.org/10.1016/j.micres.2008.08.006 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.5.- {ECO:0000269|PubMed:18950999} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.5.- {ECO:0000269|PubMed:18950999} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EMBL X66836 http://www.ebi.ac.uk/ena/data/view/X66836 ENZYME 3.6.5.- {ECO:0000269|PubMed:18950999} http://enzyme.expasy.org/EC/3.6.5.- {ECO:0000269|PubMed:18950999} EchoBASE EB1415 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1415 EcoGene EG11445 http://www.ecogene.org/geneInfo.php?eg_id=EG11445 EnsemblBacteria AAC75955 http://www.ensemblgenomes.org/id/AAC75955 EnsemblBacteria AAC75955 http://www.ensemblgenomes.org/id/AAC75955 EnsemblBacteria BAE76982 http://www.ensemblgenomes.org/id/BAE76982 EnsemblBacteria BAE76982 http://www.ensemblgenomes.org/id/BAE76982 EnsemblBacteria BAE76982 http://www.ensemblgenomes.org/id/BAE76982 EnsemblBacteria b2918 http://www.ensemblgenomes.org/id/b2918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_function GO:0000155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000155 GO_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 1.10.287.130 http://www.cathdb.info/version/latest/superfamily/1.10.287.130 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947412 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947412 HOGENOM HOG000003902 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000003902&db=HOGENOM6 InParanoid P27254 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P27254 IntAct P27254 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P27254* IntEnz 3.6.5.- {ECO:0000269|PubMed:18950999} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.5.- {ECO:0000269|PubMed:18950999} InterPro IPR003661 http://www.ebi.ac.uk/interpro/entry/IPR003661 InterPro IPR005129 http://www.ebi.ac.uk/interpro/entry/IPR005129 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2885 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2885 KEGG_Gene eco:b2918 http://www.genome.jp/dbget-bin/www_bget?eco:b2918 KEGG_Orthology KO:K07588 http://www.genome.jp/dbget-bin/www_bget?KO:K07588 OMA NKADGPH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NKADGPH PDB 2P67 http://www.ebi.ac.uk/pdbe-srv/view/entry/2P67 PDBsum 2P67 http://www.ebi.ac.uk/pdbsum/2P67 PSORT swissprot:ARGK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARGK_ECOLI PSORT-B swissprot:ARGK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARGK_ECOLI PSORT2 swissprot:ARGK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARGK_ECOLI Phobius swissprot:ARGK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARGK_ECOLI PhylomeDB P27254 http://phylomedb.org/?seqid=P27254 ProteinModelPortal P27254 http://www.proteinmodelportal.org/query/uniprot/P27254 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18950999 http://www.ncbi.nlm.nih.gov/pubmed/18950999 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9733684 http://www.ncbi.nlm.nih.gov/pubmed/9733684 RefSeq NP_417393 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417393 RefSeq WP_000606525 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000606525 SMR P27254 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P27254 STRING 511145.b2918 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2918&targetmode=cogs STRING COG1703 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1703&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR00750 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00750 UniProtKB ARGK_ECOLI http://www.uniprot.org/uniprot/ARGK_ECOLI UniProtKB-AC P27254 http://www.uniprot.org/uniprot/P27254 charge swissprot:ARGK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARGK_ECOLI eggNOG COG1703 http://eggnogapi.embl.de/nog_data/html/tree/COG1703 eggNOG ENOG4105DJT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DJT epestfind swissprot:ARGK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARGK_ECOLI garnier swissprot:ARGK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARGK_ECOLI helixturnhelix swissprot:ARGK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARGK_ECOLI hmoment swissprot:ARGK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARGK_ECOLI iep swissprot:ARGK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARGK_ECOLI inforesidue swissprot:ARGK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARGK_ECOLI octanol swissprot:ARGK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARGK_ECOLI pepcoil swissprot:ARGK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARGK_ECOLI pepdigest swissprot:ARGK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARGK_ECOLI pepinfo swissprot:ARGK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARGK_ECOLI pepnet swissprot:ARGK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARGK_ECOLI pepstats swissprot:ARGK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARGK_ECOLI pepwheel swissprot:ARGK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARGK_ECOLI pepwindow swissprot:ARGK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARGK_ECOLI sigcleave swissprot:ARGK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARGK_ECOLI ## Database ID URL or Descriptions # BioGrid 4261240 9 # EcoGene EG11694 yidF # IntAct P31443 8 # Organism YIDF_ECOLI Escherichia coli (strain K12) # PATRIC 32122839 VBIEscCol129921_3795 # PIR C65169 C65169 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIDF_ECOLI Uncharacterized protein YidF # RefSeq NP_418130 NC_000913.3 # RefSeq WP_000148061 NZ_LN832404.1 # eggNOG COG0641 LUCA # eggNOG ENOG4105J13 Bacteria BLAST swissprot:YIDF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIDF_ECOLI BioCyc ECOL316407:JW3650-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3650-MONOMER BioCyc EcoCyc:EG11694-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11694-MONOMER COG COG0641 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0641 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1645 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1645 EcoGene EG11694 http://www.ecogene.org/geneInfo.php?eg_id=EG11694 EnsemblBacteria AAC76697 http://www.ensemblgenomes.org/id/AAC76697 EnsemblBacteria AAC76697 http://www.ensemblgenomes.org/id/AAC76697 EnsemblBacteria BAE77619 http://www.ensemblgenomes.org/id/BAE77619 EnsemblBacteria BAE77619 http://www.ensemblgenomes.org/id/BAE77619 EnsemblBacteria BAE77619 http://www.ensemblgenomes.org/id/BAE77619 EnsemblBacteria b3674 http://www.ensemblgenomes.org/id/b3674 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 948179 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948179 HOGENOM HOG000000300 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000000300&db=HOGENOM6 IntAct P31443 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31443* KEGG_Gene ecj:JW3650 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3650 KEGG_Gene eco:b3674 http://www.genome.jp/dbget-bin/www_bget?eco:b3674 KEGG_Orthology KO:K06871 http://www.genome.jp/dbget-bin/www_bget?KO:K06871 OMA VEAPDKA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VEAPDKA PSORT swissprot:YIDF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIDF_ECOLI PSORT-B swissprot:YIDF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIDF_ECOLI PSORT2 swissprot:YIDF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIDF_ECOLI Phobius swissprot:YIDF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIDF_ECOLI PhylomeDB P31443 http://phylomedb.org/?seqid=P31443 ProteinModelPortal P31443 http://www.proteinmodelportal.org/query/uniprot/P31443 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418130 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418130 RefSeq WP_000148061 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000148061 SMR P31443 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31443 STRING 511145.b3674 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3674&targetmode=cogs STRING COG0641 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0641&targetmode=cogs UniProtKB YIDF_ECOLI http://www.uniprot.org/uniprot/YIDF_ECOLI UniProtKB-AC P31443 http://www.uniprot.org/uniprot/P31443 charge swissprot:YIDF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIDF_ECOLI eggNOG COG0641 http://eggnogapi.embl.de/nog_data/html/tree/COG0641 eggNOG ENOG4105J13 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105J13 epestfind swissprot:YIDF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIDF_ECOLI garnier swissprot:YIDF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIDF_ECOLI helixturnhelix swissprot:YIDF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIDF_ECOLI hmoment swissprot:YIDF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIDF_ECOLI iep swissprot:YIDF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIDF_ECOLI inforesidue swissprot:YIDF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIDF_ECOLI octanol swissprot:YIDF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIDF_ECOLI pepcoil swissprot:YIDF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIDF_ECOLI pepdigest swissprot:YIDF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIDF_ECOLI pepinfo swissprot:YIDF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIDF_ECOLI pepnet swissprot:YIDF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIDF_ECOLI pepstats swissprot:YIDF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIDF_ECOLI pepwheel swissprot:YIDF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIDF_ECOLI pepwindow swissprot:YIDF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIDF_ECOLI sigcleave swissprot:YIDF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIDF_ECOLI ## Database ID URL or Descriptions # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # GO_process GO:0031555 transcriptional attenuation; IMP:EcoCyc. # GOslim_process GO:0008150 biological_process # Organism LPRH_ECOLI Escherichia coli (strain K12) # PIR A05111 A05111 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LPRH_ECOLI Putative rho operon leader peptide # RefSeq WP_001295255 NZ_LN832404.1 BLAST swissprot:LPRH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LPRH_ECOLI BioCyc ECOL316407:JW3755-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3755-MONOMER BioCyc EcoCyc:EG12428-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12428-MONOMER DOI 10.1016/0022-2836(82)90527-7 http://dx.doi.org/10.1016/0022-2836(82)90527-7 DOI 10.1016/0378-1119(84)90015-5 http://dx.doi.org/10.1016/0378-1119(84)90015-5 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/11.11.3531 http://dx.doi.org/10.1093/nar/11.11.3531 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01673 http://www.ebi.ac.uk/ena/data/view/J01673 EMBL K02845 http://www.ebi.ac.uk/ena/data/view/K02845 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4306 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4306 EnsemblBacteria BAE77516 http://www.ensemblgenomes.org/id/BAE77516 EnsemblBacteria BAE77516 http://www.ensemblgenomes.org/id/BAE77516 EnsemblBacteria BAE77516 http://www.ensemblgenomes.org/id/BAE77516 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0031555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031555 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 IntAct P0ADF3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADF3* KEGG_Gene ecj:JW3755 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3755 PSORT swissprot:LPRH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LPRH_ECOLI PSORT-B swissprot:LPRH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LPRH_ECOLI PSORT2 swissprot:LPRH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LPRH_ECOLI Phobius swissprot:LPRH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LPRH_ECOLI ProteinModelPortal P0ADF3 http://www.proteinmodelportal.org/query/uniprot/P0ADF3 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6099324 http://www.ncbi.nlm.nih.gov/pubmed/6099324 PubMed 6219230 http://www.ncbi.nlm.nih.gov/pubmed/6219230 PubMed 6304634 http://www.ncbi.nlm.nih.gov/pubmed/6304634 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001295255 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295255 STRING 316407.85676266 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85676266&targetmode=cogs UniProtKB LPRH_ECOLI http://www.uniprot.org/uniprot/LPRH_ECOLI UniProtKB-AC P0ADF3 http://www.uniprot.org/uniprot/P0ADF3 charge swissprot:LPRH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LPRH_ECOLI epestfind swissprot:LPRH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LPRH_ECOLI garnier swissprot:LPRH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LPRH_ECOLI helixturnhelix swissprot:LPRH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LPRH_ECOLI hmoment swissprot:LPRH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LPRH_ECOLI iep swissprot:LPRH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LPRH_ECOLI inforesidue swissprot:LPRH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LPRH_ECOLI octanol swissprot:LPRH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LPRH_ECOLI pepcoil swissprot:LPRH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LPRH_ECOLI pepdigest swissprot:LPRH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LPRH_ECOLI pepinfo swissprot:LPRH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LPRH_ECOLI pepnet swissprot:LPRH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LPRH_ECOLI pepstats swissprot:LPRH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LPRH_ECOLI pepwheel swissprot:LPRH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LPRH_ECOLI pepwindow swissprot:LPRH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LPRH_ECOLI sigcleave swissprot:LPRH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LPRH_ECOLI ## Database ID URL or Descriptions # AltName AMPN_ECOLI Alpha-aminoacylpeptide hydrolase # BRENDA 3.4.11 2026 # BioGrid 4261880 12 # CATALYTIC ACTIVITY AMPN_ECOLI Release of an N-terminal amino acid, Xaa-|- Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide. {ECO 0000269|PubMed 16885166, ECO 0000269|PubMed 18416562, ECO 0000269|PubMed 19622865}. # CDD cd09600 M1_APN_1 # COFACTOR AMPN_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 16885166, ECO 0000269|PubMed 18416562, ECO 0000269|PubMed 19622865}; Note=Binds 1 zinc ion per subunit. {ECO 0000269|PubMed 16885166, ECO 0000269|PubMed 18416562, ECO 0000269|PubMed 19622865}; # DISRUPTION PHENOTYPE A quadruple peptidase disruption (pepA, pepB, pepD and pepN) does not grow in M9 minimal medium, does grow better when supplemented with casamino acids (PubMed:20067529). {ECO 0000269|PubMed:20067529}. # EcoGene EG10696 pepN # FUNCTION AMPN_ECOLI Aminopeptidase N is involved in the degradation of intracellular peptides generated by protein breakdown during normal growth as well as in response to nutrient starvation. {ECO 0000269|PubMed 16885166, ECO 0000269|PubMed 18416562, ECO 0000269|PubMed 19622865, ECO 0000305|PubMed 20067529}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_component GO:0005886 plasma membrane; IBA:GO_Central. # GO_function GO:0004177 aminopeptidase activity; IDA:EcoliWiki. # GO_function GO:0008270 zinc ion binding; IBA:GO_Central. # GO_function GO:0042277 peptide binding; IBA:GO_Central. # GO_function GO:0070006 metalloaminopeptidase activity; IBA:GO_Central. # GO_process GO:0006508 proteolysis; IMP:EcoCyc. # GO_process GO:0043171 peptide catabolic process; IGI:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.25.50.10 -; 1. # INTERACTION AMPN_ECOLI Self; NbExp=2; IntAct=EBI-545385, EBI-545385; # IntAct P04825 13 # InterPro IPR001930 Peptidase_M1 # InterPro IPR012779 Peptidase_M1_pepN # InterPro IPR014782 Peptidase_M1_N # InterPro IPR024601 Peptidase_M1_pepN_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # KEGG_Pathway ko00480 Glutathione metabolism # Organism AMPN_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11533 PTHR11533; 2 # PATRIC 32117083 VBIEscCol129921_0966 # PDB 2DQ6 X-ray; 1.50 A; A=1-870 # PDB 2DQM X-ray; 1.60 A; A=1-870 # PDB 2HPO X-ray; 1.65 A; A=1-870 # PDB 2HPT X-ray; 2.30 A; A=1-870 # PDB 2ZXG X-ray; 1.55 A; A=1-870 # PDB 3B2P X-ray; 2.00 A; A=1-870 # PDB 3B2X X-ray; 1.50 A; A=1-870 # PDB 3B34 X-ray; 1.30 A; A=1-870 # PDB 3B37 X-ray; 1.70 A; A=1-870 # PDB 3B3B X-ray; 1.85 A; A=1-870 # PDB 3KED X-ray; 2.30 A; A=1-870 # PDB 3PUU X-ray; 2.15 A; A=1-870 # PDB 3QJX X-ray; 1.45 A; A=1-870 # PDB 4Q4E X-ray; 1.90 A; A=1-870 # PDB 4Q4I X-ray; 2.31 A; A=1-870 # PDB 4XMT X-ray; 2.00 A; A=4-870 # PDB 4XMU X-ray; 2.91 A; A=5-870 # PDB 4XMV X-ray; 2.92 A; A=5-870 # PDB 4XMW X-ray; 2.20 A; A=4-870 # PDB 4XMX X-ray; 2.30 A; A=5-870 # PDB 4XMZ X-ray; 2.15 A; A=4-870 # PDB 4XN1 X-ray; 2.20 A; A=4-870 # PDB 4XN2 X-ray; 2.11 A; A=5-870 # PDB 4XN4 X-ray; 1.99 A; A=5-870 # PDB 4XN5 X-ray; 2.66 A; A=5-870 # PDB 4XN7 X-ray; 2.22 A; A=5-870 # PDB 4XN8 X-ray; 1.89 A; A=5-870 # PDB 4XN9 X-ray; 2.80 A; A=5-870 # PDB 4XNA X-ray; 2.40 A; A=5-870 # PDB 4XNB X-ray; 1.95 A; A=5-870 # PDB 4XND X-ray; 1.93 A; A=5-870 # PDB 4XO3 X-ray; 2.00 A; A=5-870 # PDB 4XO4 X-ray; 2.18 A; A=1-870 # PDB 4XO5 X-ray; 1.98 A; A=5-870 # PIR C64833 DPECN # PRINTS PR00756 ALADIPTASE # PROSITE PS00142 ZINC_PROTEASE # Pfam PF01433 Peptidase_M1 # Pfam PF11940 DUF3458 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AMPN_ECOLI Aminopeptidase N # RefSeq NP_415452 NC_000913.3 # RefSeq WP_000193841 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase M1 family. {ECO 0000305}. # SUBCELLULAR LOCATION AMPN_ECOLI Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. # TIGRFAMs TIGR02414 pepN_proteo # eggNOG COG0308 LUCA # eggNOG ENOG4105CD8 Bacteria BLAST swissprot:AMPN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AMPN_ECOLI BioCyc ECOL316407:JW0915-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0915-MONOMER BioCyc EcoCyc:EG10696-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10696-MONOMER BioCyc MetaCyc:EG10696-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10696-MONOMER COG COG0308 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0308 DIP DIP-10458N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10458N DOI 10.1007/BF00330202 http://dx.doi.org/10.1007/BF00330202 DOI 10.1016/0378-1119(86)90360-4 http://dx.doi.org/10.1016/0378-1119(86)90360-4 DOI 10.1016/0378-1119(86)90366-5 http://dx.doi.org/10.1016/0378-1119(86)90366-5 DOI 10.1021/bi7022333 http://dx.doi.org/10.1021/bi7022333 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M605203200 http://dx.doi.org/10.1074/jbc.M605203200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1107/S090744490901779X http://dx.doi.org/10.1107/S090744490901779X DOI 10.1111/j.1432-1033.1986.tb09525.x http://dx.doi.org/10.1111/j.1432-1033.1986.tb09525.x DOI 10.1111/j.1574-6968.2009.01879.x http://dx.doi.org/10.1111/j.1574-6968.2009.01879.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.11.2 {ECO:0000269|PubMed:16885166, ECO:0000269|PubMed:18416562, ECO:0000269|PubMed:19622865} http://www.genome.jp/dbget-bin/www_bget?EC:3.4.11.2 {ECO:0000269|PubMed:16885166, ECO:0000269|PubMed:18416562, ECO:0000269|PubMed:19622865} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M15273 http://www.ebi.ac.uk/ena/data/view/M15273 EMBL M15676 http://www.ebi.ac.uk/ena/data/view/M15676 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X03709 http://www.ebi.ac.uk/ena/data/view/X03709 EMBL X04020 http://www.ebi.ac.uk/ena/data/view/X04020 ENZYME 3.4.11.2 {ECO:0000269|PubMed:16885166, ECO:0000269|PubMed:18416562, ECO:0000269|PubMed:19622865} http://enzyme.expasy.org/EC/3.4.11.2 {ECO:0000269|PubMed:16885166, ECO:0000269|PubMed:18416562, ECO:0000269|PubMed:19622865} EchoBASE EB0690 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0690 EcoGene EG10696 http://www.ecogene.org/geneInfo.php?eg_id=EG10696 EnsemblBacteria AAC74018 http://www.ensemblgenomes.org/id/AAC74018 EnsemblBacteria AAC74018 http://www.ensemblgenomes.org/id/AAC74018 EnsemblBacteria BAA35684 http://www.ensemblgenomes.org/id/BAA35684 EnsemblBacteria BAA35684 http://www.ensemblgenomes.org/id/BAA35684 EnsemblBacteria BAA35684 http://www.ensemblgenomes.org/id/BAA35684 EnsemblBacteria b0932 http://www.ensemblgenomes.org/id/b0932 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0004177 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004177 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0042277 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042277 GO_function GO:0070006 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070006 GO_process GO:0006508 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006508 GO_process GO:0043171 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043171 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.25.50.10 http://www.cathdb.info/version/latest/superfamily/1.25.50.10 GeneID 947253 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947253 HOGENOM HOG000257670 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000257670&db=HOGENOM6 InParanoid P04825 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P04825 IntAct P04825 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P04825* IntEnz 3.4.11.2 {ECO:0000269|PubMed:16885166, ECO:0000269|PubMed:18416562, ECO:0000269|PubMed:19622865} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.11.2 {ECO:0000269|PubMed:16885166, ECO:0000269|PubMed:18416562, ECO:0000269|PubMed:19622865} InterPro IPR001930 http://www.ebi.ac.uk/interpro/entry/IPR001930 InterPro IPR012779 http://www.ebi.ac.uk/interpro/entry/IPR012779 InterPro IPR014782 http://www.ebi.ac.uk/interpro/entry/IPR014782 InterPro IPR024601 http://www.ebi.ac.uk/interpro/entry/IPR024601 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW0915 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0915 KEGG_Gene eco:b0932 http://www.genome.jp/dbget-bin/www_bget?eco:b0932 KEGG_Orthology KO:K01256 http://www.genome.jp/dbget-bin/www_bget?KO:K01256 KEGG_Pathway ko00480 http://www.genome.jp/kegg-bin/show_pathway?ko00480 KEGG_Reaction rn:R00899 http://www.genome.jp/dbget-bin/www_bget?rn:R00899 KEGG_Reaction rn:R04951 http://www.genome.jp/dbget-bin/www_bget?rn:R04951 MINT MINT-1310653 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1310653 OMA MIVAVND http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MIVAVND PANTHER PTHR11533 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11533 PDB 2DQ6 http://www.ebi.ac.uk/pdbe-srv/view/entry/2DQ6 PDB 2DQM http://www.ebi.ac.uk/pdbe-srv/view/entry/2DQM PDB 2HPO http://www.ebi.ac.uk/pdbe-srv/view/entry/2HPO PDB 2HPT http://www.ebi.ac.uk/pdbe-srv/view/entry/2HPT PDB 2ZXG http://www.ebi.ac.uk/pdbe-srv/view/entry/2ZXG PDB 3B2P http://www.ebi.ac.uk/pdbe-srv/view/entry/3B2P PDB 3B2X http://www.ebi.ac.uk/pdbe-srv/view/entry/3B2X PDB 3B34 http://www.ebi.ac.uk/pdbe-srv/view/entry/3B34 PDB 3B37 http://www.ebi.ac.uk/pdbe-srv/view/entry/3B37 PDB 3B3B http://www.ebi.ac.uk/pdbe-srv/view/entry/3B3B PDB 3KED http://www.ebi.ac.uk/pdbe-srv/view/entry/3KED PDB 3PUU http://www.ebi.ac.uk/pdbe-srv/view/entry/3PUU PDB 3QJX http://www.ebi.ac.uk/pdbe-srv/view/entry/3QJX PDB 4Q4E http://www.ebi.ac.uk/pdbe-srv/view/entry/4Q4E PDB 4Q4I http://www.ebi.ac.uk/pdbe-srv/view/entry/4Q4I PDB 4XMT http://www.ebi.ac.uk/pdbe-srv/view/entry/4XMT PDB 4XMU http://www.ebi.ac.uk/pdbe-srv/view/entry/4XMU PDB 4XMV http://www.ebi.ac.uk/pdbe-srv/view/entry/4XMV PDB 4XMW http://www.ebi.ac.uk/pdbe-srv/view/entry/4XMW PDB 4XMX http://www.ebi.ac.uk/pdbe-srv/view/entry/4XMX PDB 4XMZ http://www.ebi.ac.uk/pdbe-srv/view/entry/4XMZ PDB 4XN1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4XN1 PDB 4XN2 http://www.ebi.ac.uk/pdbe-srv/view/entry/4XN2 PDB 4XN4 http://www.ebi.ac.uk/pdbe-srv/view/entry/4XN4 PDB 4XN5 http://www.ebi.ac.uk/pdbe-srv/view/entry/4XN5 PDB 4XN7 http://www.ebi.ac.uk/pdbe-srv/view/entry/4XN7 PDB 4XN8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4XN8 PDB 4XN9 http://www.ebi.ac.uk/pdbe-srv/view/entry/4XN9 PDB 4XNA http://www.ebi.ac.uk/pdbe-srv/view/entry/4XNA PDB 4XNB http://www.ebi.ac.uk/pdbe-srv/view/entry/4XNB PDB 4XND http://www.ebi.ac.uk/pdbe-srv/view/entry/4XND PDB 4XO3 http://www.ebi.ac.uk/pdbe-srv/view/entry/4XO3 PDB 4XO4 http://www.ebi.ac.uk/pdbe-srv/view/entry/4XO4 PDB 4XO5 http://www.ebi.ac.uk/pdbe-srv/view/entry/4XO5 PDBsum 2DQ6 http://www.ebi.ac.uk/pdbsum/2DQ6 PDBsum 2DQM http://www.ebi.ac.uk/pdbsum/2DQM PDBsum 2HPO http://www.ebi.ac.uk/pdbsum/2HPO PDBsum 2HPT http://www.ebi.ac.uk/pdbsum/2HPT PDBsum 2ZXG http://www.ebi.ac.uk/pdbsum/2ZXG PDBsum 3B2P http://www.ebi.ac.uk/pdbsum/3B2P PDBsum 3B2X http://www.ebi.ac.uk/pdbsum/3B2X PDBsum 3B34 http://www.ebi.ac.uk/pdbsum/3B34 PDBsum 3B37 http://www.ebi.ac.uk/pdbsum/3B37 PDBsum 3B3B http://www.ebi.ac.uk/pdbsum/3B3B PDBsum 3KED http://www.ebi.ac.uk/pdbsum/3KED PDBsum 3PUU http://www.ebi.ac.uk/pdbsum/3PUU PDBsum 3QJX http://www.ebi.ac.uk/pdbsum/3QJX PDBsum 4Q4E http://www.ebi.ac.uk/pdbsum/4Q4E PDBsum 4Q4I http://www.ebi.ac.uk/pdbsum/4Q4I PDBsum 4XMT http://www.ebi.ac.uk/pdbsum/4XMT PDBsum 4XMU http://www.ebi.ac.uk/pdbsum/4XMU PDBsum 4XMV http://www.ebi.ac.uk/pdbsum/4XMV PDBsum 4XMW http://www.ebi.ac.uk/pdbsum/4XMW PDBsum 4XMX http://www.ebi.ac.uk/pdbsum/4XMX PDBsum 4XMZ http://www.ebi.ac.uk/pdbsum/4XMZ PDBsum 4XN1 http://www.ebi.ac.uk/pdbsum/4XN1 PDBsum 4XN2 http://www.ebi.ac.uk/pdbsum/4XN2 PDBsum 4XN4 http://www.ebi.ac.uk/pdbsum/4XN4 PDBsum 4XN5 http://www.ebi.ac.uk/pdbsum/4XN5 PDBsum 4XN7 http://www.ebi.ac.uk/pdbsum/4XN7 PDBsum 4XN8 http://www.ebi.ac.uk/pdbsum/4XN8 PDBsum 4XN9 http://www.ebi.ac.uk/pdbsum/4XN9 PDBsum 4XNA http://www.ebi.ac.uk/pdbsum/4XNA PDBsum 4XNB http://www.ebi.ac.uk/pdbsum/4XNB PDBsum 4XND http://www.ebi.ac.uk/pdbsum/4XND PDBsum 4XO3 http://www.ebi.ac.uk/pdbsum/4XO3 PDBsum 4XO4 http://www.ebi.ac.uk/pdbsum/4XO4 PDBsum 4XO5 http://www.ebi.ac.uk/pdbsum/4XO5 PRINTS PR00756 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00756 PROSITE PS00142 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00142 PSORT swissprot:AMPN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AMPN_ECOLI PSORT-B swissprot:AMPN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AMPN_ECOLI PSORT2 swissprot:AMPN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AMPN_ECOLI Pfam PF01433 http://pfam.xfam.org/family/PF01433 Pfam PF11940 http://pfam.xfam.org/family/PF11940 Phobius swissprot:AMPN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AMPN_ECOLI PhylomeDB P04825 http://phylomedb.org/?seqid=P04825 ProteinModelPortal P04825 http://www.proteinmodelportal.org/query/uniprot/P04825 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16885166 http://www.ncbi.nlm.nih.gov/pubmed/16885166 PubMed 18416562 http://www.ncbi.nlm.nih.gov/pubmed/18416562 PubMed 19622865 http://www.ncbi.nlm.nih.gov/pubmed/19622865 PubMed 20067529 http://www.ncbi.nlm.nih.gov/pubmed/20067529 PubMed 2436977 http://www.ncbi.nlm.nih.gov/pubmed/2436977 PubMed 2869947 http://www.ncbi.nlm.nih.gov/pubmed/2869947 PubMed 3018440 http://www.ncbi.nlm.nih.gov/pubmed/3018440 PubMed 3549459 http://www.ncbi.nlm.nih.gov/pubmed/3549459 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415452 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415452 RefSeq WP_000193841 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000193841 SMR P04825 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P04825 STRING 511145.b0932 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0932&targetmode=cogs STRING COG0308 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0308&targetmode=cogs TIGRFAMs TIGR02414 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02414 UniProtKB AMPN_ECOLI http://www.uniprot.org/uniprot/AMPN_ECOLI UniProtKB-AC P04825 http://www.uniprot.org/uniprot/P04825 charge swissprot:AMPN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AMPN_ECOLI eggNOG COG0308 http://eggnogapi.embl.de/nog_data/html/tree/COG0308 eggNOG ENOG4105CD8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CD8 epestfind swissprot:AMPN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AMPN_ECOLI garnier swissprot:AMPN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AMPN_ECOLI helixturnhelix swissprot:AMPN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AMPN_ECOLI hmoment swissprot:AMPN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AMPN_ECOLI iep swissprot:AMPN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AMPN_ECOLI inforesidue swissprot:AMPN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AMPN_ECOLI octanol swissprot:AMPN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AMPN_ECOLI pepcoil swissprot:AMPN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AMPN_ECOLI pepdigest swissprot:AMPN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AMPN_ECOLI pepinfo swissprot:AMPN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AMPN_ECOLI pepnet swissprot:AMPN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AMPN_ECOLI pepstats swissprot:AMPN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AMPN_ECOLI pepwheel swissprot:AMPN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AMPN_ECOLI pepwindow swissprot:AMPN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AMPN_ECOLI sigcleave swissprot:AMPN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AMPN_ECOLI ## Database ID URL or Descriptions # BioGrid 4259163 7 # EcoGene EG13387 yeeT # IntAct P64521 6 # InterPro IPR009329 DUF987 # Organism YEET_ECOLI Escherichia coli (strain K12) # PATRIC 32119339 VBIEscCol129921_2079 # PIR B64965 B64965 # Pfam PF06174 DUF987 # ProDom PD056719 DUF987 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEET_ECOLI Uncharacterized protein YeeT # RefSeq NP_416507 NC_000913.3 # RefSeq WP_000692323 NZ_LN832404.1 # SIMILARITY Belongs to the YeeT/YkfH/YpjJ family. {ECO 0000305}. BLAST swissprot:YEET_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEET_ECOLI BioCyc ECOL316407:JW1985-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1985-MONOMER BioCyc EcoCyc:G7083-MONOMER http://biocyc.org/getid?id=EcoCyc:G7083-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3168 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3168 EcoGene EG13387 http://www.ecogene.org/geneInfo.php?eg_id=EG13387 EnsemblBacteria AAC75064 http://www.ensemblgenomes.org/id/AAC75064 EnsemblBacteria AAC75064 http://www.ensemblgenomes.org/id/AAC75064 EnsemblBacteria BAE76564 http://www.ensemblgenomes.org/id/BAE76564 EnsemblBacteria BAE76564 http://www.ensemblgenomes.org/id/BAE76564 EnsemblBacteria BAE76564 http://www.ensemblgenomes.org/id/BAE76564 EnsemblBacteria b2003 http://www.ensemblgenomes.org/id/b2003 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946513 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946513 HOGENOM HOG000267802 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267802&db=HOGENOM6 IntAct P64521 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P64521* InterPro IPR009329 http://www.ebi.ac.uk/interpro/entry/IPR009329 KEGG_Gene ecj:JW1985 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1985 KEGG_Gene eco:b2003 http://www.genome.jp/dbget-bin/www_bget?eco:b2003 OMA EAMHIHR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EAMHIHR PSORT swissprot:YEET_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEET_ECOLI PSORT-B swissprot:YEET_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEET_ECOLI PSORT2 swissprot:YEET_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEET_ECOLI Pfam PF06174 http://pfam.xfam.org/family/PF06174 Phobius swissprot:YEET_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEET_ECOLI PhylomeDB P64521 http://phylomedb.org/?seqid=P64521 ProteinModelPortal P64521 http://www.proteinmodelportal.org/query/uniprot/P64521 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416507 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416507 RefSeq WP_000692323 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000692323 SMR P64521 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P64521 STRING 511145.b2003 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2003&targetmode=cogs UniProtKB YEET_ECOLI http://www.uniprot.org/uniprot/YEET_ECOLI UniProtKB-AC P64521 http://www.uniprot.org/uniprot/P64521 charge swissprot:YEET_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEET_ECOLI epestfind swissprot:YEET_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEET_ECOLI garnier swissprot:YEET_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEET_ECOLI helixturnhelix swissprot:YEET_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEET_ECOLI hmoment swissprot:YEET_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEET_ECOLI iep swissprot:YEET_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEET_ECOLI inforesidue swissprot:YEET_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEET_ECOLI octanol swissprot:YEET_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEET_ECOLI pepcoil swissprot:YEET_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEET_ECOLI pepdigest swissprot:YEET_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEET_ECOLI pepinfo swissprot:YEET_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEET_ECOLI pepnet swissprot:YEET_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEET_ECOLI pepstats swissprot:YEET_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEET_ECOLI pepwheel swissprot:YEET_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEET_ECOLI pepwindow swissprot:YEET_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEET_ECOLI sigcleave swissprot:YEET_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEET_ECOLI ## Database ID URL or Descriptions # BioGrid 4261907 82 # DOMAIN SEQA_ECOLI The N-terminal domain is required for multimerization. The C-terminal domain is involved in DNA-binding. {ECO 0000269|PubMed 12379844, ECO 0000269|PubMed 12507506, ECO 0000269|PubMed 19304745}. # EcoGene EG12197 seqA # FUNCTION SEQA_ECOLI Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. Can also bind to hemimethylated GATC sequences outside of oriC region. Binds, with less affinity, to fully methylated GATC sites and affects timing of replication. May play a role in chromosome organization and gene regulation. {ECO 0000255|HAMAP-Rule MF_00908, ECO 0000269|PubMed 10931282, ECO 0000269|PubMed 11080170, ECO 0000269|PubMed 20689753, ECO 0000269|PubMed 7553853, ECO 0000269|PubMed 7891562, ECO 0000269|PubMed 8011018}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:1990097 SeqA-DNA complex; IDA:EcoCyc. # GO_function GO:0003688 DNA replication origin binding; IDA:EcoCyc. # GO_function GO:0010385 double-stranded methylated DNA binding; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IPI:IntAct. # GO_function GO:0044729 hemi-methylated DNA-binding; IDA:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:InterPro. # GO_process GO:0007062 sister chromatid cohesion; IGI:EcoCyc. # GO_process GO:0032297 negative regulation of DNA-dependent DNA replication initiation; IMP:EcoCyc. # GO_process GO:0051289 protein homotetramerization; IDA:EcoCyc. # GO_process GO:0090143 nucleoid organization; IGI:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0008150 biological_process # GOslim_process GO:0051276 chromosome organization # Gene3D 1.10.1220.10 -; 1. # Gene3D 1.20.1380.10 -; 1. # HAMAP MF_00908 SeqA # INTERACTION SEQA_ECOLI Self; NbExp=13; IntAct=EBI-552553, EBI-552553; P0A8F8 uvrB; NbExp=2; IntAct=EBI-552553, EBI-552176; # IntAct P0AFY8 3 # InterPro IPR005621 SeqA # InterPro IPR010985 Ribbon_hlx_hlx # InterPro IPR013321 Arc_rbn_hlx_hlx # InterPro IPR026577 SeqA_DNA-bd_C # InterPro IPR033761 SeqA_N # KEGG_Brite ko03032 DNA replication proteins # KEGG_Brite ko03036 Chromosome # Organism SEQA_ECOLI Escherichia coli (strain K12) # PATRIC 32116567 VBIEscCol129921_0716 # PDB 1IU3 X-ray; 3.00 A; C/F=71-181 # PDB 1J3E X-ray; 2.50 A; A=71-181 # PDB 1LRR X-ray; 2.65 A; A/D=51-181 # PDB 1XRX X-ray; 2.15 A; A/B/C/D=1-50 # PDB 2CH3 Model; -; A=1-181 # PDB 3FMT X-ray; 2.98 A; A/B/E/F=1-181 # PIR A54296 A54296 # PIRSF PIRSF019401 SeqA # Pfam PF03925 SeqA # Pfam PF17206 SeqA_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Negative modulator of initiation of replication {ECO:0000255|HAMAP-Rule MF_00908} # RefSeq NP_415213 NC_000913.3 # RefSeq WP_000848387 NZ_LN832404.1 # SIMILARITY Belongs to the SeqA family. {ECO:0000255|HAMAP- Rule MF_00908}. # SUBCELLULAR LOCATION SEQA_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00908, ECO 0000269|PubMed 9660922}. Note=Localization is cell cycle- dependent. Localizes at midcell in newborn cells, then migrates in opposite directions toward cell quarter sites and remains tethered there until the cell divides. # SUBUNIT SEQA_ECOLI Homodimer. Polymerizes to form helical filaments. Dimerization is sufficient for DNA-binding, but oligomerization is essential for function. {ECO 0000255|HAMAP-Rule MF_00908, ECO 0000269|PubMed 12379844, ECO 0000269|PubMed 14704346, ECO 0000269|PubMed 15933720, ECO 0000269|PubMed 19304745}. # SUPFAM SSF47598 SSF47598 # SUPFAM SSF82808 SSF82808 # eggNOG COG3057 LUCA # eggNOG ENOG4107CDU Bacteria BLAST swissprot:SEQA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SEQA_ECOLI BioCyc ECOL316407:JW0674-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0674-MONOMER BioCyc EcoCyc:EG12197-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12197-MONOMER COG COG3057 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3057 DIP DIP-48017N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48017N DOI 10.1016/0092-8674(94)90156-2 http://dx.doi.org/10.1016/0092-8674(94)90156-2 DOI 10.1016/0092-8674(95)90272-4 http://dx.doi.org/10.1016/0092-8674(95)90272-4 DOI 10.1016/S0006-291X(02)02891-7 http://dx.doi.org/10.1016/S0006-291X(02)02891-7 DOI 10.1016/S0960-9822(00)00214-1 http://dx.doi.org/10.1016/S0960-9822(00)00214-1 DOI 10.1016/S1097-2765(00)80038-6 http://dx.doi.org/10.1016/S1097-2765(00)80038-6 DOI 10.1016/j.patbio.2008.03.013 http://dx.doi.org/10.1016/j.patbio.2008.03.013 DOI 10.1016/j.plasmid.2009.02.004 http://dx.doi.org/10.1016/j.plasmid.2009.02.004 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb857 http://dx.doi.org/10.1038/nsb857 DOI 10.1038/sj.emboj.7600634 http://dx.doi.org/10.1038/sj.emboj.7600634 DOI 10.1046/j.1365-2958.2000.01943.x http://dx.doi.org/10.1046/j.1365-2958.2000.01943.x DOI 10.1073/pnas.95.19.11117 http://dx.doi.org/10.1073/pnas.95.19.11117 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/emboj/19.22.6249 http://dx.doi.org/10.1093/emboj/19.22.6249 DOI 10.1093/nar/gkh173 http://dx.doi.org/10.1093/nar/gkh173 DOI 10.1093/nar/gkp151 http://dx.doi.org/10.1093/nar/gkp151 DOI 10.1111/j.1365-2958.1994.tb01313.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb01313.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/mBio.00012-10 http://dx.doi.org/10.1128/mBio.00012-10 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U07651 http://www.ebi.ac.uk/ena/data/view/U07651 EchoBASE EB2114 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2114 EcoGene EG12197 http://www.ecogene.org/geneInfo.php?eg_id=EG12197 EnsemblBacteria AAC73781 http://www.ensemblgenomes.org/id/AAC73781 EnsemblBacteria AAC73781 http://www.ensemblgenomes.org/id/AAC73781 EnsemblBacteria BAA35336 http://www.ensemblgenomes.org/id/BAA35336 EnsemblBacteria BAA35336 http://www.ensemblgenomes.org/id/BAA35336 EnsemblBacteria BAA35336 http://www.ensemblgenomes.org/id/BAA35336 EnsemblBacteria b0687 http://www.ensemblgenomes.org/id/b0687 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:1990097 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990097 GO_function GO:0003688 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003688 GO_function GO:0010385 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010385 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0044729 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044729 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0007062 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007062 GO_process GO:0032297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032297 GO_process GO:0051289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051289 GO_process GO:0090143 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090143 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0051276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051276 Gene3D 1.10.1220.10 http://www.cathdb.info/version/latest/superfamily/1.10.1220.10 Gene3D 1.20.1380.10 http://www.cathdb.info/version/latest/superfamily/1.20.1380.10 GeneID 945272 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945272 HAMAP MF_00908 http://hamap.expasy.org/unirule/MF_00908 HOGENOM HOG000275226 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275226&db=HOGENOM6 IntAct P0AFY8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFY8* InterPro IPR005621 http://www.ebi.ac.uk/interpro/entry/IPR005621 InterPro IPR010985 http://www.ebi.ac.uk/interpro/entry/IPR010985 InterPro IPR013321 http://www.ebi.ac.uk/interpro/entry/IPR013321 InterPro IPR026577 http://www.ebi.ac.uk/interpro/entry/IPR026577 InterPro IPR033761 http://www.ebi.ac.uk/interpro/entry/IPR033761 KEGG_Brite ko03032 http://www.genome.jp/dbget-bin/www_bget?ko03032 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene ecj:JW0674 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0674 KEGG_Gene eco:b0687 http://www.genome.jp/dbget-bin/www_bget?eco:b0687 KEGG_Orthology KO:K03645 http://www.genome.jp/dbget-bin/www_bget?KO:K03645 MINT MINT-1238758 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1238758 OMA RTRTYFA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RTRTYFA PDB 1IU3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1IU3 PDB 1J3E http://www.ebi.ac.uk/pdbe-srv/view/entry/1J3E PDB 1LRR http://www.ebi.ac.uk/pdbe-srv/view/entry/1LRR PDB 1XRX http://www.ebi.ac.uk/pdbe-srv/view/entry/1XRX PDB 2CH3 http://www.ebi.ac.uk/pdbe-srv/view/entry/2CH3 PDB 3FMT http://www.ebi.ac.uk/pdbe-srv/view/entry/3FMT PDBsum 1IU3 http://www.ebi.ac.uk/pdbsum/1IU3 PDBsum 1J3E http://www.ebi.ac.uk/pdbsum/1J3E PDBsum 1LRR http://www.ebi.ac.uk/pdbsum/1LRR PDBsum 1XRX http://www.ebi.ac.uk/pdbsum/1XRX PDBsum 2CH3 http://www.ebi.ac.uk/pdbsum/2CH3 PDBsum 3FMT http://www.ebi.ac.uk/pdbsum/3FMT PSORT swissprot:SEQA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SEQA_ECOLI PSORT-B swissprot:SEQA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SEQA_ECOLI PSORT2 swissprot:SEQA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SEQA_ECOLI Pfam PF03925 http://pfam.xfam.org/family/PF03925 Pfam PF17206 http://pfam.xfam.org/family/PF17206 Phobius swissprot:SEQA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SEQA_ECOLI ProteinModelPortal P0AFY8 http://www.proteinmodelportal.org/query/uniprot/P0AFY8 PubMed 10931282 http://www.ncbi.nlm.nih.gov/pubmed/10931282 PubMed 11080170 http://www.ncbi.nlm.nih.gov/pubmed/11080170 PubMed 12379844 http://www.ncbi.nlm.nih.gov/pubmed/12379844 PubMed 12507506 http://www.ncbi.nlm.nih.gov/pubmed/12507506 PubMed 14704346 http://www.ncbi.nlm.nih.gov/pubmed/14704346 PubMed 15933720 http://www.ncbi.nlm.nih.gov/pubmed/15933720 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18849124 http://www.ncbi.nlm.nih.gov/pubmed/18849124 PubMed 19254745 http://www.ncbi.nlm.nih.gov/pubmed/19254745 PubMed 19304745 http://www.ncbi.nlm.nih.gov/pubmed/19304745 PubMed 20689753 http://www.ncbi.nlm.nih.gov/pubmed/20689753 PubMed 7553853 http://www.ncbi.nlm.nih.gov/pubmed/7553853 PubMed 7850437 http://www.ncbi.nlm.nih.gov/pubmed/7850437 PubMed 7891562 http://www.ncbi.nlm.nih.gov/pubmed/7891562 PubMed 8011018 http://www.ncbi.nlm.nih.gov/pubmed/8011018 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9660922 http://www.ncbi.nlm.nih.gov/pubmed/9660922 PubMed 9736699 http://www.ncbi.nlm.nih.gov/pubmed/9736699 RefSeq NP_415213 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415213 RefSeq WP_000848387 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000848387 SMR P0AFY8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFY8 STRING 511145.b0687 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0687&targetmode=cogs STRING COG3057 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3057&targetmode=cogs SUPFAM SSF47598 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47598 SUPFAM SSF82808 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF82808 UniProtKB SEQA_ECOLI http://www.uniprot.org/uniprot/SEQA_ECOLI UniProtKB-AC P0AFY8 http://www.uniprot.org/uniprot/P0AFY8 charge swissprot:SEQA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SEQA_ECOLI eggNOG COG3057 http://eggnogapi.embl.de/nog_data/html/tree/COG3057 eggNOG ENOG4107CDU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107CDU epestfind swissprot:SEQA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SEQA_ECOLI garnier swissprot:SEQA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SEQA_ECOLI helixturnhelix swissprot:SEQA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SEQA_ECOLI hmoment swissprot:SEQA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SEQA_ECOLI iep swissprot:SEQA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SEQA_ECOLI inforesidue swissprot:SEQA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SEQA_ECOLI octanol swissprot:SEQA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SEQA_ECOLI pepcoil swissprot:SEQA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SEQA_ECOLI pepdigest swissprot:SEQA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SEQA_ECOLI pepinfo swissprot:SEQA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SEQA_ECOLI pepnet swissprot:SEQA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SEQA_ECOLI pepstats swissprot:SEQA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SEQA_ECOLI pepwheel swissprot:SEQA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SEQA_ECOLI pepwindow swissprot:SEQA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SEQA_ECOLI sigcleave swissprot:SEQA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SEQA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260543 220 # EcoGene EG14133 yfdI # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # Organism YFDI_ECOLI Escherichia coli (strain K12) # PATRIC 32120077 VBIEscCol129921_2447 # PIR E65008 E65008 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFDI_ECOLI Uncharacterized protein YfdI # RefSeq NP_416853 NC_000913.3 # RefSeq WP_001030215 NZ_LN832404.1 # SUBCELLULAR LOCATION YFDI_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. BLAST swissprot:YFDI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFDI_ECOLI BioCyc ECOL316407:JW5382-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5382-MONOMER BioCyc EcoCyc:G7221-MONOMER http://biocyc.org/getid?id=EcoCyc:G7221-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3885 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3885 EcoGene EG14133 http://www.ecogene.org/geneInfo.php?eg_id=EG14133 EnsemblBacteria AAC75411 http://www.ensemblgenomes.org/id/AAC75411 EnsemblBacteria AAC75411 http://www.ensemblgenomes.org/id/AAC75411 EnsemblBacteria BAE76694 http://www.ensemblgenomes.org/id/BAE76694 EnsemblBacteria BAE76694 http://www.ensemblgenomes.org/id/BAE76694 EnsemblBacteria BAE76694 http://www.ensemblgenomes.org/id/BAE76694 EnsemblBacteria b2352 http://www.ensemblgenomes.org/id/b2352 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 946822 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946822 KEGG_Gene ecj:JW5382 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5382 KEGG_Gene eco:b2352 http://www.genome.jp/dbget-bin/www_bget?eco:b2352 OMA NNIYQSV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NNIYQSV PSORT swissprot:YFDI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFDI_ECOLI PSORT-B swissprot:YFDI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFDI_ECOLI PSORT2 swissprot:YFDI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFDI_ECOLI Phobius swissprot:YFDI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFDI_ECOLI ProteinModelPortal P76507 http://www.proteinmodelportal.org/query/uniprot/P76507 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416853 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416853 RefSeq WP_001030215 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001030215 STRING 511145.b2352 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2352&targetmode=cogs UniProtKB YFDI_ECOLI http://www.uniprot.org/uniprot/YFDI_ECOLI UniProtKB-AC P76507 http://www.uniprot.org/uniprot/P76507 charge swissprot:YFDI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFDI_ECOLI epestfind swissprot:YFDI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFDI_ECOLI garnier swissprot:YFDI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFDI_ECOLI helixturnhelix swissprot:YFDI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFDI_ECOLI hmoment swissprot:YFDI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFDI_ECOLI iep swissprot:YFDI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFDI_ECOLI inforesidue swissprot:YFDI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFDI_ECOLI octanol swissprot:YFDI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFDI_ECOLI pepcoil swissprot:YFDI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFDI_ECOLI pepdigest swissprot:YFDI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFDI_ECOLI pepinfo swissprot:YFDI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFDI_ECOLI pepnet swissprot:YFDI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFDI_ECOLI pepstats swissprot:YFDI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFDI_ECOLI pepwheel swissprot:YFDI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFDI_ECOLI pepwindow swissprot:YFDI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFDI_ECOLI sigcleave swissprot:YFDI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFDI_ECOLI ## Database ID URL or Descriptions # BioGrid 4259927 6 # EcoGene EG11521 ybfA # IntAct P0AAU2 3 # InterPro IPR019663 YbfA # Organism YBFA_ECOLI Escherichia coli (strain K12) # PATRIC 32116595 VBIEscCol129921_0730 # PIR B64805 B64805 # Pfam PF10725 DUF2517 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBFA_ECOLI Uncharacterized protein YbfA # RefSeq NP_415228 NC_000913.3 # RefSeq WP_000424924 NZ_LN832404.1 # eggNOG ENOG4105XIQ Bacteria # eggNOG ENOG41123Q8 LUCA BLAST swissprot:YBFA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBFA_ECOLI BioCyc ECOL316407:JW0688-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0688-MONOMER BioCyc EcoCyc:EG11521-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11521-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L02373 http://www.ebi.ac.uk/ena/data/view/L02373 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1483 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1483 EcoGene EG11521 http://www.ecogene.org/geneInfo.php?eg_id=EG11521 EnsemblBacteria AAC73793 http://www.ensemblgenomes.org/id/AAC73793 EnsemblBacteria AAC73793 http://www.ensemblgenomes.org/id/AAC73793 EnsemblBacteria BAA35358 http://www.ensemblgenomes.org/id/BAA35358 EnsemblBacteria BAA35358 http://www.ensemblgenomes.org/id/BAA35358 EnsemblBacteria BAA35358 http://www.ensemblgenomes.org/id/BAA35358 EnsemblBacteria b0699 http://www.ensemblgenomes.org/id/b0699 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947452 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947452 HOGENOM HOG000281014 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000281014&db=HOGENOM6 IntAct P0AAU2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAU2* InterPro IPR019663 http://www.ebi.ac.uk/interpro/entry/IPR019663 KEGG_Gene ecj:JW0688 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0688 KEGG_Gene eco:b0699 http://www.genome.jp/dbget-bin/www_bget?eco:b0699 OMA HRVWAKT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HRVWAKT PSORT swissprot:YBFA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBFA_ECOLI PSORT-B swissprot:YBFA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBFA_ECOLI PSORT2 swissprot:YBFA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBFA_ECOLI Pfam PF10725 http://pfam.xfam.org/family/PF10725 Phobius swissprot:YBFA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBFA_ECOLI ProteinModelPortal P0AAU2 http://www.proteinmodelportal.org/query/uniprot/P0AAU2 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8387990 http://www.ncbi.nlm.nih.gov/pubmed/8387990 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415228 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415228 RefSeq WP_000424924 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000424924 STRING 511145.b0699 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0699&targetmode=cogs UniProtKB YBFA_ECOLI http://www.uniprot.org/uniprot/YBFA_ECOLI UniProtKB-AC P0AAU2 http://www.uniprot.org/uniprot/P0AAU2 charge swissprot:YBFA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBFA_ECOLI eggNOG ENOG4105XIQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105XIQ eggNOG ENOG41123Q8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41123Q8 epestfind swissprot:YBFA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBFA_ECOLI garnier swissprot:YBFA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBFA_ECOLI helixturnhelix swissprot:YBFA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBFA_ECOLI hmoment swissprot:YBFA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBFA_ECOLI iep swissprot:YBFA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBFA_ECOLI inforesidue swissprot:YBFA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBFA_ECOLI octanol swissprot:YBFA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBFA_ECOLI pepcoil swissprot:YBFA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBFA_ECOLI pepdigest swissprot:YBFA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBFA_ECOLI pepinfo swissprot:YBFA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBFA_ECOLI pepnet swissprot:YBFA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBFA_ECOLI pepstats swissprot:YBFA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBFA_ECOLI pepwheel swissprot:YBFA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBFA_ECOLI pepwindow swissprot:YBFA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBFA_ECOLI sigcleave swissprot:YBFA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBFA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262115 17 # CAUTION Could be the product of a pseudogene. The original sequence is interrupted after position 103 and the C-terminal 552 amino acids are deleted. {ECO 0000305}. # EcoGene EG14308 yoeA # GO_component GO:0016020 membrane; IEA:InterPro. # GO_function GO:0004872 receptor activity; IEA:InterPro. # GO_process GO:0006810 transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006810 transport # Gene3D 2.170.130.10 -; 1. # IntAct P76356 4 # InterPro IPR012910 Plug_dom # Organism YOEA_ECOLI Escherichia coli (strain K12) # PATRIC 48663337 VBIEscCol107702_2016 # PIR B64964 B64964 # PIR E64964 E64964 # Pfam PF07715 Plug # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YOEA_ECOLI Putative uncharacterized protein YoeA # eggNOG COG1629 LUCA BLAST swissprot:YOEA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YOEA_ECOLI BioCyc ECOL316407:JW1980-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1980-MONOMER BioCyc EcoCyc:G7075-MONOMER http://biocyc.org/getid?id=EcoCyc:G7075-MONOMER BioCyc EcoCyc:G7078-MONOMER http://biocyc.org/getid?id=EcoCyc:G7078-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14308 http://www.ecogene.org/geneInfo.php?eg_id=EG14308 EnsemblBacteria BAA15823 http://www.ensemblgenomes.org/id/BAA15823 EnsemblBacteria BAA15823 http://www.ensemblgenomes.org/id/BAA15823 EnsemblBacteria BAA15823 http://www.ensemblgenomes.org/id/BAA15823 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0004872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004872 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 2.170.130.10 http://www.cathdb.info/version/latest/superfamily/2.170.130.10 InParanoid P76356 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76356 IntAct P76356 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76356* InterPro IPR012910 http://www.ebi.ac.uk/interpro/entry/IPR012910 KEGG_Gene ecj:JW1980 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1980 PSORT swissprot:YOEA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YOEA_ECOLI PSORT-B swissprot:YOEA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YOEA_ECOLI PSORT2 swissprot:YOEA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YOEA_ECOLI Pfam PF07715 http://pfam.xfam.org/family/PF07715 Phobius swissprot:YOEA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YOEA_ECOLI ProteinModelPortal P76356 http://www.proteinmodelportal.org/query/uniprot/P76356 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SMR P76356 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76356 STRING 316407.85675182 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85675182&targetmode=cogs UniProtKB YOEA_ECOLI http://www.uniprot.org/uniprot/YOEA_ECOLI UniProtKB-AC P76356 http://www.uniprot.org/uniprot/P76356 charge swissprot:YOEA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YOEA_ECOLI eggNOG COG1629 http://eggnogapi.embl.de/nog_data/html/tree/COG1629 epestfind swissprot:YOEA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YOEA_ECOLI garnier swissprot:YOEA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YOEA_ECOLI helixturnhelix swissprot:YOEA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YOEA_ECOLI hmoment swissprot:YOEA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YOEA_ECOLI iep swissprot:YOEA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YOEA_ECOLI inforesidue swissprot:YOEA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YOEA_ECOLI octanol swissprot:YOEA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YOEA_ECOLI pepcoil swissprot:YOEA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YOEA_ECOLI pepdigest swissprot:YOEA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YOEA_ECOLI pepinfo swissprot:YOEA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YOEA_ECOLI pepnet swissprot:YOEA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YOEA_ECOLI pepstats swissprot:YOEA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YOEA_ECOLI pepwheel swissprot:YOEA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YOEA_ECOLI pepwindow swissprot:YOEA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YOEA_ECOLI sigcleave swissprot:YOEA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YOEA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262629 6 # CATALYTIC ACTIVITY NTRB_ECOLI ATP + protein L-histidine = ADP + protein N- phospho-L-histidine. # EcoGene EG10387 glnL # FUNCTION NTRB_ECOLI NtrB acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of NtrC. In nitrogen limitation NtrB activates NtrC by phosphorylating it, while in nitrogen excess NtrC is dephosphorylated and consequently inactivated by NtrB. # GO_component GO:0005622 intracellular; IDA:EcoCyc. # GO_function GO:0000155 phosphorelay sensor kinase activity; IDA:EcoCyc. # GO_function GO:0004721 phosphoprotein phosphatase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0000160 phosphorelay signal transduction system; IDA:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:InterPro. # GO_process GO:0009399 nitrogen fixation; IEA:UniProtKB-KW. # GO_process GO:0046777 protein autophosphorylation; IMP:EcoCyc. # GO_process GO:0051171 regulation of nitrogen compound metabolic process; IMP:EcoCyc. # GOslim_component GO:0005622 intracellular # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0071941 nitrogen cycle metabolic process # Gene3D 1.10.287.130 -; 1. # Gene3D 3.30.565.10 -; 1. # INTERACTION NTRB_ECOLI Self; NbExp=3; IntAct=EBI-701156, EBI-701156; P0A9Z1 glnB; NbExp=5; IntAct=EBI-701156, EBI-551053; P0AFB8 glnG; NbExp=3; IntAct=EBI-701156, EBI-1113197; P0AC55 glnK; NbExp=5; IntAct=EBI-701156, EBI-559503; P09153 tfaE; NbExp=4; IntAct=EBI-701156, EBI-9133821; # IntAct P0AFB5 10 # InterPro IPR000014 PAS # InterPro IPR003594 HATPase_C # InterPro IPR003661 HisK_dim/P # InterPro IPR004358 Sig_transdc_His_kin-like_C # InterPro IPR005467 His_kinase_dom # InterPro IPR013767 PAS_fold # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01001 Protein kinases # KEGG_Brite ko02022 M00497 GlnL-GlnG (nitrogen regulation) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # Organism NTRB_ECOLI Escherichia coli (strain K12) # PATRIC 32123241 VBIEscCol129921_3981 # PDB 1R62 X-ray; 1.60 A; A=190-349 # PIR A30377 RGECGL # PRINTS PR00344 BCTRLSENSOR # PROSITE PS50109 HIS_KIN # PROSITE PS50112 PAS # Pfam PF00512 HisKA # Pfam PF00989 PAS # Pfam PF02518 HATPase_c # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NTRB_ECOLI Nitrogen regulation protein NR(II) # RefSeq NP_418305 NC_000913.3 # RefSeq WP_000190577 NZ_LN832404.1 # SIMILARITY Contains 1 PAS (PER-ARNT-SIM) domain. {ECO:0000255|PROSITE-ProRule PRU00140}. # SIMILARITY Contains 1 histidine kinase domain. {ECO:0000255|PROSITE-ProRule PRU00107}. # SMART SM00091 PAS # SMART SM00387 HATPase_c # SMART SM00388 HisKA # SUPFAM SSF47384 SSF47384 # SUPFAM SSF55785 SSF55785 # SUPFAM SSF55874 SSF55874 # eggNOG COG3852 LUCA # eggNOG ENOG4105CUX Bacteria BLAST swissprot:NTRB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NTRB_ECOLI BioCyc ECOL316407:JW3840-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3840-MONOMER BioCyc EcoCyc:PROTEIN-NRII http://biocyc.org/getid?id=EcoCyc:PROTEIN-NRII COG COG3852 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3852 DIP DIP-9784N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9784N DOI 10.1016/0378-1119(85)90261-6 http://dx.doi.org/10.1016/0378-1119(85)90261-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/15.6.2757 http://dx.doi.org/10.1093/nar/15.6.2757 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.13.3 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.13.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K02176 http://www.ebi.ac.uk/ena/data/view/K02176 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X05173 http://www.ebi.ac.uk/ena/data/view/X05173 ENZYME 2.7.13.3 http://enzyme.expasy.org/EC/2.7.13.3 EchoBASE EB0382 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0382 EcoGene EG10387 http://www.ecogene.org/geneInfo.php?eg_id=EG10387 EnsemblBacteria AAC76866 http://www.ensemblgenomes.org/id/AAC76866 EnsemblBacteria AAC76866 http://www.ensemblgenomes.org/id/AAC76866 EnsemblBacteria BAE77440 http://www.ensemblgenomes.org/id/BAE77440 EnsemblBacteria BAE77440 http://www.ensemblgenomes.org/id/BAE77440 EnsemblBacteria BAE77440 http://www.ensemblgenomes.org/id/BAE77440 EnsemblBacteria b3869 http://www.ensemblgenomes.org/id/b3869 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_function GO:0000155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000155 GO_function GO:0004721 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004721 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0009399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009399 GO_process GO:0046777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046777 GO_process GO:0051171 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051171 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0071941 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071941 Gene3D 1.10.287.130 http://www.cathdb.info/version/latest/superfamily/1.10.287.130 Gene3D 3.30.565.10 http://www.cathdb.info/version/latest/superfamily/3.30.565.10 GeneID 948360 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948360 HOGENOM HOG000262169 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000262169&db=HOGENOM6 InParanoid P0AFB5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFB5 IntAct P0AFB5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFB5* IntEnz 2.7.13.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.13.3 InterPro IPR000014 http://www.ebi.ac.uk/interpro/entry/IPR000014 InterPro IPR003594 http://www.ebi.ac.uk/interpro/entry/IPR003594 InterPro IPR003661 http://www.ebi.ac.uk/interpro/entry/IPR003661 InterPro IPR004358 http://www.ebi.ac.uk/interpro/entry/IPR004358 InterPro IPR005467 http://www.ebi.ac.uk/interpro/entry/IPR005467 InterPro IPR013767 http://www.ebi.ac.uk/interpro/entry/IPR013767 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01001 http://www.genome.jp/dbget-bin/www_bget?ko01001 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW3840 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3840 KEGG_Gene eco:b3869 http://www.genome.jp/dbget-bin/www_bget?eco:b3869 KEGG_Orthology KO:K07708 http://www.genome.jp/dbget-bin/www_bget?KO:K07708 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA EMRKIDQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EMRKIDQ PDB 1R62 http://www.ebi.ac.uk/pdbe-srv/view/entry/1R62 PDBsum 1R62 http://www.ebi.ac.uk/pdbsum/1R62 PRINTS PR00344 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00344 PROSITE PS50109 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50109 PROSITE PS50112 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50112 PSORT swissprot:NTRB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NTRB_ECOLI PSORT-B swissprot:NTRB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NTRB_ECOLI PSORT2 swissprot:NTRB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NTRB_ECOLI Pfam PF00512 http://pfam.xfam.org/family/PF00512 Pfam PF00989 http://pfam.xfam.org/family/PF00989 Pfam PF02518 http://pfam.xfam.org/family/PF02518 Phobius swissprot:NTRB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NTRB_ECOLI PhylomeDB P0AFB5 http://phylomedb.org/?seqid=P0AFB5 ProteinModelPortal P0AFB5 http://www.proteinmodelportal.org/query/uniprot/P0AFB5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2016302 http://www.ncbi.nlm.nih.gov/pubmed/2016302 PubMed 2865194 http://www.ncbi.nlm.nih.gov/pubmed/2865194 PubMed 2882477 http://www.ncbi.nlm.nih.gov/pubmed/2882477 PubMed 6148334 http://www.ncbi.nlm.nih.gov/pubmed/6148334 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418305 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418305 RefSeq WP_000190577 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000190577 SMART SM00091 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00091 SMART SM00387 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00387 SMART SM00388 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00388 SMR P0AFB5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFB5 STRING 511145.b3869 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3869&targetmode=cogs STRING COG3852 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3852&targetmode=cogs SUPFAM SSF47384 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47384 SUPFAM SSF55785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55785 SUPFAM SSF55874 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55874 UniProtKB NTRB_ECOLI http://www.uniprot.org/uniprot/NTRB_ECOLI UniProtKB-AC P0AFB5 http://www.uniprot.org/uniprot/P0AFB5 charge swissprot:NTRB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NTRB_ECOLI eggNOG COG3852 http://eggnogapi.embl.de/nog_data/html/tree/COG3852 eggNOG ENOG4105CUX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CUX epestfind swissprot:NTRB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NTRB_ECOLI garnier swissprot:NTRB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NTRB_ECOLI helixturnhelix swissprot:NTRB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NTRB_ECOLI hmoment swissprot:NTRB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NTRB_ECOLI iep swissprot:NTRB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NTRB_ECOLI inforesidue swissprot:NTRB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NTRB_ECOLI octanol swissprot:NTRB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NTRB_ECOLI pepcoil swissprot:NTRB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NTRB_ECOLI pepdigest swissprot:NTRB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NTRB_ECOLI pepinfo swissprot:NTRB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NTRB_ECOLI pepnet swissprot:NTRB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NTRB_ECOLI pepstats swissprot:NTRB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NTRB_ECOLI pepwheel swissprot:NTRB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NTRB_ECOLI pepwindow swissprot:NTRB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NTRB_ECOLI sigcleave swissprot:NTRB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NTRB_ECOLI ## Database ID URL or Descriptions # BRENDA 3.5.3.23 2026 # BioGrid 4262234 10 # CATALYTIC ACTIVITY ASTB_ECOLI N(2)-succinyl-L-arginine + 2 H(2)O = N(2)- succinyl-L-ornithine + 2 NH(3) + CO(2). # EcoGene EG13996 astB # FUNCTION ASTB_ECOLI Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2). {ECO 0000269|PubMed 15703173, ECO 0000269|PubMed 9696779}. # GO_function GO:0009015 N-succinylarginine dihydrolase activity; IDA:EcoCyc. # GO_process GO:0006527 arginine catabolic process; IMP:EcoliWiki. # GO_process GO:0019544 arginine catabolic process to glutamate; IEA:UniProtKB-HAMAP. # GO_process GO:0019545 arginine catabolic process to succinate; IEA:UniProtKB-UniPathway. # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # Gene3D 3.75.10.20 -; 1. # HAMAP MF_01172 AstB # INDUCTION By nitrogen starvation, and arginine. Induced at stationary phase via sigma S. {ECO:0000269|PubMed 12003934}. # InterPro IPR007079 SuccinylArg_d-Hdrlase_AstB # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00330 Arginine and proline metabolism # Organism ASTB_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine step 2/5. # PATRIC 32118799 VBIEscCol129921_1817 # PDB 1YNF X-ray; 1.90 A; A/B/C/D/E/F=2-447 # PDB 1YNH X-ray; 1.95 A; A/B/C/D=2-447 # PDB 1YNI X-ray; 2.20 A; A/B/C/D=2-447 # PIR A64934 A64934 # Pfam PF04996 AstB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ASTB_ECOLI N-succinylarginine dihydrolase # RefSeq NP_416259 NC_000913.3 # RefSeq WP_000994973 NZ_LN832404.1 # SIMILARITY Belongs to the succinylarginine dihydrolase family. {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 15703173}. # TIGRFAMs TIGR03241 arg_catab_astB # UniPathway UPA00185 UER00280 # eggNOG COG3724 LUCA # eggNOG ENOG4105EY2 Bacteria BLAST swissprot:ASTB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ASTB_ECOLI BioCyc ECOL316407:JW1734-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1734-MONOMER BioCyc EcoCyc:SUCCARGDIHYDRO-MONOMER http://biocyc.org/getid?id=EcoCyc:SUCCARGDIHYDRO-MONOMER BioCyc MetaCyc:SUCCARGDIHYDRO-MONOMER http://biocyc.org/getid?id=MetaCyc:SUCCARGDIHYDRO-MONOMER COG COG3724 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3724 DOI 10.1016/S0014-5793(03)01314-0 http://dx.doi.org/10.1016/S0014-5793(03)01314-0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M413833200 http://dx.doi.org/10.1074/jbc.M413833200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.11.2940-2950.2002 http://dx.doi.org/10.1128/JB.184.11.2940-2950.2002 EC_number EC:3.5.3.23 http://www.genome.jp/dbget-bin/www_bget?EC:3.5.3.23 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.5.3.23 http://enzyme.expasy.org/EC/3.5.3.23 EchoBASE EB3752 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3752 EcoGene EG13996 http://www.ecogene.org/geneInfo.php?eg_id=EG13996 EnsemblBacteria AAC74815 http://www.ensemblgenomes.org/id/AAC74815 EnsemblBacteria AAC74815 http://www.ensemblgenomes.org/id/AAC74815 EnsemblBacteria BAE76516 http://www.ensemblgenomes.org/id/BAE76516 EnsemblBacteria BAE76516 http://www.ensemblgenomes.org/id/BAE76516 EnsemblBacteria BAE76516 http://www.ensemblgenomes.org/id/BAE76516 EnsemblBacteria b1745 http://www.ensemblgenomes.org/id/b1745 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0009015 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009015 GO_process GO:0006527 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006527 GO_process GO:0019544 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019544 GO_process GO:0019545 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019545 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 3.75.10.20 http://www.cathdb.info/version/latest/superfamily/3.75.10.20 GeneID 946259 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946259 HAMAP MF_01172 http://hamap.expasy.org/unirule/MF_01172 HOGENOM HOG000226005 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000226005&db=HOGENOM6 InParanoid P76216 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76216 IntAct P76216 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76216* IntEnz 3.5.3.23 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.3.23 InterPro IPR007079 http://www.ebi.ac.uk/interpro/entry/IPR007079 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1734 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1734 KEGG_Gene eco:b1745 http://www.genome.jp/dbget-bin/www_bget?eco:b1745 KEGG_Orthology KO:K01484 http://www.genome.jp/dbget-bin/www_bget?KO:K01484 KEGG_Pathway ko00330 http://www.genome.jp/kegg-bin/show_pathway?ko00330 KEGG_Reaction rn:R04189 http://www.genome.jp/dbget-bin/www_bget?rn:R04189 OMA RVAMNDQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RVAMNDQ PDB 1YNF http://www.ebi.ac.uk/pdbe-srv/view/entry/1YNF PDB 1YNH http://www.ebi.ac.uk/pdbe-srv/view/entry/1YNH PDB 1YNI http://www.ebi.ac.uk/pdbe-srv/view/entry/1YNI PDBsum 1YNF http://www.ebi.ac.uk/pdbsum/1YNF PDBsum 1YNH http://www.ebi.ac.uk/pdbsum/1YNH PDBsum 1YNI http://www.ebi.ac.uk/pdbsum/1YNI PSORT swissprot:ASTB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ASTB_ECOLI PSORT-B swissprot:ASTB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ASTB_ECOLI PSORT2 swissprot:ASTB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ASTB_ECOLI Pfam PF04996 http://pfam.xfam.org/family/PF04996 Phobius swissprot:ASTB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ASTB_ECOLI ProteinModelPortal P76216 http://www.proteinmodelportal.org/query/uniprot/P76216 PubMed 12003934 http://www.ncbi.nlm.nih.gov/pubmed/12003934 PubMed 14675764 http://www.ncbi.nlm.nih.gov/pubmed/14675764 PubMed 15703173 http://www.ncbi.nlm.nih.gov/pubmed/15703173 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9696779 http://www.ncbi.nlm.nih.gov/pubmed/9696779 RefSeq NP_416259 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416259 RefSeq WP_000994973 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000994973 SMR P76216 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76216 STRING 511145.b1745 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1745&targetmode=cogs STRING COG3724 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3724&targetmode=cogs TIGRFAMs TIGR03241 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03241 UniProtKB ASTB_ECOLI http://www.uniprot.org/uniprot/ASTB_ECOLI UniProtKB-AC P76216 http://www.uniprot.org/uniprot/P76216 charge swissprot:ASTB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ASTB_ECOLI eggNOG COG3724 http://eggnogapi.embl.de/nog_data/html/tree/COG3724 eggNOG ENOG4105EY2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EY2 epestfind swissprot:ASTB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ASTB_ECOLI garnier swissprot:ASTB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ASTB_ECOLI helixturnhelix swissprot:ASTB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ASTB_ECOLI hmoment swissprot:ASTB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ASTB_ECOLI iep swissprot:ASTB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ASTB_ECOLI inforesidue swissprot:ASTB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ASTB_ECOLI octanol swissprot:ASTB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ASTB_ECOLI pepcoil swissprot:ASTB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ASTB_ECOLI pepdigest swissprot:ASTB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ASTB_ECOLI pepinfo swissprot:ASTB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ASTB_ECOLI pepnet swissprot:ASTB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ASTB_ECOLI pepstats swissprot:ASTB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ASTB_ECOLI pepwheel swissprot:ASTB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ASTB_ECOLI pepwindow swissprot:ASTB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ASTB_ECOLI sigcleave swissprot:ASTB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ASTB_ECOLI ## Database ID URL or Descriptions # AltName MEPA_ECOLI D-alanyl-D-alanine-endopeptidase # BIOPHYSICOCHEMICAL PROPERTIES pH dependence: Optimum pH is 5-8. {ECO 0000269|PubMed:15292190}; # BioGrid 4259647 309 # CATALYTIC ACTIVITY Splits the D-alanyl-gamma-meso-2,6-diamino- pimelyl peptide bond connecting neighboring peptidoglycan strands. {ECO:0000269|PubMed 15292190}. # COFACTOR MEPA_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 15292190}; Note=Binds 2 Zn(2+) ions per subunit. Zn(2+) ion 1 is bound in the active site. Zn(2+) ion 2 is bound at the dimer interface by residues from both subunits. {ECO 0000269|PubMed 15292190}; # ENZYME REGULATION Inhibited by Zn(2+) at 10 mM and by metal chelating agents EDTA and 1,10-phenanthroline. {ECO:0000269|PubMed 15292190}. # EcoGene EG10580 mepA # FUNCTION MEPA_ECOLI Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein. {ECO 0000269|PubMed 15292190}. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IEA:InterPro. # GO_function GO:0004175 endopeptidase activity; IMP:EcoCyc. # GO_function GO:0004222 metalloendopeptidase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0004252 serine-type endopeptidase activity; IEA:InterPro. # GO_function GO:0008233 peptidase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0000270 peptidoglycan metabolic process; IDA:EcoCyc. # GO_process GO:0009252 peptidoglycan biosynthetic process; IDA:EcoCyc. # GO_process GO:0042493 response to drug; IEP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.30.1380.10 -; 1. # HAMAP MF_01623 MepA # InterPro IPR005073 Peptidase_M74 # InterPro IPR009045 Hedgehog_sig/DD-Pept_Zn-bd_dom # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # MASS SPECTROMETRY Mass=28295; Method=Unknown; Range=20-274; Evidence={ECO:0000269|PubMed 15292190}; # MISCELLANEOUS In E.coli there are three murein endopeptidases: two are penicillin sensitive (DacB and PbpG), the other (MepA) not. {ECO 0000269|PubMed:15292190}. # Organism MEPA_ECOLI Escherichia coli (strain K12) # PATRIC 32120029 VBIEscCol129921_2424 # PDB 1TZP X-ray; 1.40 A; A/B=20-274 # PDB 1U10 X-ray; 2.40 A; A/B/C/D/E/F=20-274 # PIR S08345 S08345 # PIRSF PIRSF018455 MepA # Pfam PF03411 Peptidase_M74 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MEPA_ECOLI Penicillin-insensitive murein endopeptidase # RefSeq NP_416831 NC_000913.3 # RefSeq WP_001043825 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase M74 family. {ECO 0000305}. # SUBCELLULAR LOCATION MEPA_ECOLI Periplasm {ECO 0000305|PubMed 15292190}. # SUBUNIT Dimer. {ECO:0000269|PubMed 15292190}. # SUPFAM SSF55166 SSF55166 # eggNOG COG3770 LUCA # eggNOG ENOG4105HPZ Bacteria BLAST swissprot:MEPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MEPA_ECOLI BioCyc ECOL316407:JW2325-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2325-MONOMER BioCyc EcoCyc:EG10580-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10580-MONOMER BioCyc MetaCyc:EG10580-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10580-MONOMER COG COG3770 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3770 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M406735200 http://dx.doi.org/10.1074/jbc.M406735200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1365-2958.1990.tb00588.x http://dx.doi.org/10.1111/j.1365-2958.1990.tb00588.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.24.- {ECO:0000269|PubMed:15292190} http://www.genome.jp/dbget-bin/www_bget?EC:3.4.24.- {ECO:0000269|PubMed:15292190} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X16909 http://www.ebi.ac.uk/ena/data/view/X16909 ENZYME 3.4.24.- {ECO:0000269|PubMed:15292190} http://enzyme.expasy.org/EC/3.4.24.- {ECO:0000269|PubMed:15292190} EchoBASE EB0575 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0575 EcoGene EG10580 http://www.ecogene.org/geneInfo.php?eg_id=EG10580 EnsemblBacteria AAC75388 http://www.ensemblgenomes.org/id/AAC75388 EnsemblBacteria AAC75388 http://www.ensemblgenomes.org/id/AAC75388 EnsemblBacteria BAA16184 http://www.ensemblgenomes.org/id/BAA16184 EnsemblBacteria BAA16184 http://www.ensemblgenomes.org/id/BAA16184 EnsemblBacteria BAA16184 http://www.ensemblgenomes.org/id/BAA16184 EnsemblBacteria b2328 http://www.ensemblgenomes.org/id/b2328 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0004175 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004175 GO_function GO:0004222 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004222 GO_function GO:0004252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004252 GO_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0000270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000270 GO_process GO:0009252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009252 GO_process GO:0042493 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.30.1380.10 http://www.cathdb.info/version/latest/superfamily/3.30.1380.10 GeneID 946812 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946812 HAMAP MF_01623 http://hamap.expasy.org/unirule/MF_01623 HOGENOM HOG000276210 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276210&db=HOGENOM6 InParanoid P0C0T5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0C0T5 IntAct P0C0T5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0C0T5* IntEnz 3.4.24.- {ECO:0000269|PubMed:15292190} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.24.- {ECO:0000269|PubMed:15292190} InterPro IPR005073 http://www.ebi.ac.uk/interpro/entry/IPR005073 InterPro IPR009045 http://www.ebi.ac.uk/interpro/entry/IPR009045 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW2325 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2325 KEGG_Gene eco:b2328 http://www.genome.jp/dbget-bin/www_bget?eco:b2328 KEGG_Orthology KO:K07261 http://www.genome.jp/dbget-bin/www_bget?KO:K07261 OMA EPFLCQQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EPFLCQQ PDB 1TZP http://www.ebi.ac.uk/pdbe-srv/view/entry/1TZP PDB 1U10 http://www.ebi.ac.uk/pdbe-srv/view/entry/1U10 PDBsum 1TZP http://www.ebi.ac.uk/pdbsum/1TZP PDBsum 1U10 http://www.ebi.ac.uk/pdbsum/1U10 PSORT swissprot:MEPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MEPA_ECOLI PSORT-B swissprot:MEPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MEPA_ECOLI PSORT2 swissprot:MEPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MEPA_ECOLI Pfam PF03411 http://pfam.xfam.org/family/PF03411 Phobius swissprot:MEPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MEPA_ECOLI ProteinModelPortal P0C0T5 http://www.proteinmodelportal.org/query/uniprot/P0C0T5 PubMed 15292190 http://www.ncbi.nlm.nih.gov/pubmed/15292190 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2187143 http://www.ncbi.nlm.nih.gov/pubmed/2187143 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416831 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416831 RefSeq WP_001043825 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001043825 SMR P0C0T5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0C0T5 STRING 511145.b2328 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2328&targetmode=cogs STRING COG3770 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3770&targetmode=cogs SUPFAM SSF55166 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55166 UniProtKB MEPA_ECOLI http://www.uniprot.org/uniprot/MEPA_ECOLI UniProtKB-AC P0C0T5 http://www.uniprot.org/uniprot/P0C0T5 charge swissprot:MEPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MEPA_ECOLI eggNOG COG3770 http://eggnogapi.embl.de/nog_data/html/tree/COG3770 eggNOG ENOG4105HPZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105HPZ epestfind swissprot:MEPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MEPA_ECOLI garnier swissprot:MEPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MEPA_ECOLI helixturnhelix swissprot:MEPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MEPA_ECOLI hmoment swissprot:MEPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MEPA_ECOLI iep swissprot:MEPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MEPA_ECOLI inforesidue swissprot:MEPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MEPA_ECOLI octanol swissprot:MEPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MEPA_ECOLI pepcoil swissprot:MEPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MEPA_ECOLI pepdigest swissprot:MEPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MEPA_ECOLI pepinfo swissprot:MEPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MEPA_ECOLI pepnet swissprot:MEPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MEPA_ECOLI pepstats swissprot:MEPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MEPA_ECOLI pepwheel swissprot:MEPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MEPA_ECOLI pepwindow swissprot:MEPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MEPA_ECOLI sigcleave swissprot:MEPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MEPA_ECOLI ## Database ID URL or Descriptions # BioGrid 4263161 78 # EcoGene EG14333 ykfI # FUNCTION YKFI_ECOLI Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures and a decrease in colony formation; these effects are overcome by concomitant expression of antitoxin YafW, which leads to toxin loss by an unknown mechanism. {ECO 0000269|PubMed 14594833}. # GO_process GO:0030308 negative regulation of cell growth; IMP:EcoCyc. # GOslim_process GO:0008150 biological_process # IntAct P77692 3 # InterPro IPR009610 CbtA_toxin # Organism YKFI_ECOLI Escherichia coli (strain K12) # PATRIC 32115605 VBIEscCol129921_0246 # PIR E64749 E64749 # Pfam PF06755 CbtA_toxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YKFI_ECOLI Toxin YkfI # RefSeq NP_414779 NC_000913.3 # RefSeq WP_000854672 NZ_LN832404.1 # SIMILARITY Belongs to the CbtA/YkfI/YpjF toxin family. {ECO 0000305}. # eggNOG ENOG4108X3P Bacteria # eggNOG ENOG4111PBJ LUCA BLAST swissprot:YKFI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YKFI_ECOLI BioCyc ECOL316407:JW0234-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0234-MONOMER BioCyc EcoCyc:G6120-MONOMER http://biocyc.org/getid?id=EcoCyc:G6120-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.185.22.6600-6608.2003 http://dx.doi.org/10.1128/JB.185.22.6600-6608.2003 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EchoBASE EB4079 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4079 EcoGene EG14333 http://www.ecogene.org/geneInfo.php?eg_id=EG14333 EnsemblBacteria AAC73348 http://www.ensemblgenomes.org/id/AAC73348 EnsemblBacteria AAC73348 http://www.ensemblgenomes.org/id/AAC73348 EnsemblBacteria BAA77913 http://www.ensemblgenomes.org/id/BAA77913 EnsemblBacteria BAA77913 http://www.ensemblgenomes.org/id/BAA77913 EnsemblBacteria BAA77913 http://www.ensemblgenomes.org/id/BAA77913 EnsemblBacteria b0245 http://www.ensemblgenomes.org/id/b0245 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0030308 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030308 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 946726 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946726 HOGENOM HOG000124769 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000124769&db=HOGENOM6 IntAct P77692 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77692* InterPro IPR009610 http://www.ebi.ac.uk/interpro/entry/IPR009610 KEGG_Gene ecj:JW0234 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0234 KEGG_Gene eco:b0245 http://www.genome.jp/dbget-bin/www_bget?eco:b0245 OMA WQEQSPF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WQEQSPF PSORT swissprot:YKFI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YKFI_ECOLI PSORT-B swissprot:YKFI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YKFI_ECOLI PSORT2 swissprot:YKFI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YKFI_ECOLI Pfam PF06755 http://pfam.xfam.org/family/PF06755 Phobius swissprot:YKFI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YKFI_ECOLI PhylomeDB P77692 http://phylomedb.org/?seqid=P77692 ProteinModelPortal P77692 http://www.proteinmodelportal.org/query/uniprot/P77692 PubMed 14594833 http://www.ncbi.nlm.nih.gov/pubmed/14594833 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414779 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414779 RefSeq WP_000854672 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000854672 STRING 511145.b0245 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0245&targetmode=cogs UniProtKB YKFI_ECOLI http://www.uniprot.org/uniprot/YKFI_ECOLI UniProtKB-AC P77692 http://www.uniprot.org/uniprot/P77692 charge swissprot:YKFI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YKFI_ECOLI eggNOG ENOG4108X3P http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108X3P eggNOG ENOG4111PBJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111PBJ epestfind swissprot:YKFI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YKFI_ECOLI garnier swissprot:YKFI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YKFI_ECOLI helixturnhelix swissprot:YKFI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YKFI_ECOLI hmoment swissprot:YKFI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YKFI_ECOLI iep swissprot:YKFI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YKFI_ECOLI inforesidue swissprot:YKFI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YKFI_ECOLI octanol swissprot:YKFI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YKFI_ECOLI pepcoil swissprot:YKFI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YKFI_ECOLI pepdigest swissprot:YKFI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YKFI_ECOLI pepinfo swissprot:YKFI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YKFI_ECOLI pepnet swissprot:YKFI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YKFI_ECOLI pepstats swissprot:YKFI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YKFI_ECOLI pepwheel swissprot:YKFI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YKFI_ECOLI pepwindow swissprot:YKFI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YKFI_ECOLI sigcleave swissprot:YKFI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YKFI_ECOLI ## Database ID URL or Descriptions # AltName TUSC_ECOLI tRNA 2-thiouridine synthesizing protein C # BioGrid 4262468 28 # EcoGene EG12897 tusC # FUNCTION TUSC_ECOLI Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. {ECO 0000269|PubMed 16387657}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_process GO:0008033 tRNA processing; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005737 cytoplasm # GOslim_process GO:0006399 tRNA metabolic process # Gene3D 3.40.1260.10 -; 1. # HAMAP MF_00389 Thiourid_synth_C # IntAct P45531 6 # InterPro IPR003787 Sulphur_relay_DrsE/F-like # InterPro IPR017462 Sulphur_relay_TusC/DsrF # InterPro IPR027396 DsrEFH-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko03016 Transfer RNA biogenesis # KEGG_Pathway ko04122 Sulfur relay system # Organism TUSC_ECOLI Escherichia coli (strain K12) # PATRIC 32122120 VBIEscCol129921_3437 # PDB 2D1P X-ray; 2.15 A; B/E/H=1-119 # PIR C65128 C65128 # Pfam PF02635 DrsE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TUSC_ECOLI Protein TusC # RefSeq NP_417803 NC_000913.3 # RefSeq WP_000820714 NZ_LN832404.1 # SIMILARITY Belongs to the DsrF/TusC family. {ECO 0000305}. # SUBCELLULAR LOCATION TUSC_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT TUSC_ECOLI Heterohexamer, formed by a dimer of trimers. The hexameric TusBCD complex contains 2 copies each of TusB, TusC and TusD. The TusBCD complex interacts with TusE. {ECO 0000269|PubMed 16387657, ECO 0000269|PubMed 16472754}. # SUPFAM SSF75169 SSF75169 # TIGRFAMs TIGR03010 sulf_tusC_dsrF # eggNOG COG2923 LUCA # eggNOG ENOG4108ZKU Bacteria BLAST swissprot:TUSC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TUSC_ECOLI BioCyc ECOL316407:JW3306-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3306-MONOMER BioCyc EcoCyc:G7713-MONOMER http://biocyc.org/getid?id=EcoCyc:G7713-MONOMER BioCyc MetaCyc:G7713-MONOMER http://biocyc.org/getid?id=MetaCyc:G7713-MONOMER COG COG2923 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2923 DIP DIP-12309N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12309N DOI 10.1016/j.molcel.2005.11.001 http://dx.doi.org/10.1016/j.molcel.2005.11.001 DOI 10.1016/j.str.2005.11.009 http://dx.doi.org/10.1016/j.str.2005.11.009 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2734 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2734 EcoGene EG12897 http://www.ecogene.org/geneInfo.php?eg_id=EG12897 EnsemblBacteria AAC76369 http://www.ensemblgenomes.org/id/AAC76369 EnsemblBacteria AAC76369 http://www.ensemblgenomes.org/id/AAC76369 EnsemblBacteria BAE77947 http://www.ensemblgenomes.org/id/BAE77947 EnsemblBacteria BAE77947 http://www.ensemblgenomes.org/id/BAE77947 EnsemblBacteria BAE77947 http://www.ensemblgenomes.org/id/BAE77947 EnsemblBacteria b3344 http://www.ensemblgenomes.org/id/b3344 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_process GO:0008033 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008033 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 Gene3D 3.40.1260.10 http://www.cathdb.info/version/latest/superfamily/3.40.1260.10 GeneID 947853 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947853 HAMAP MF_00389 http://hamap.expasy.org/unirule/MF_00389 HOGENOM HOG000284344 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000284344&db=HOGENOM6 InParanoid P45531 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45531 IntAct P45531 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45531* InterPro IPR003787 http://www.ebi.ac.uk/interpro/entry/IPR003787 InterPro IPR017462 http://www.ebi.ac.uk/interpro/entry/IPR017462 InterPro IPR027396 http://www.ebi.ac.uk/interpro/entry/IPR027396 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW3306 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3306 KEGG_Gene eco:b3344 http://www.genome.jp/dbget-bin/www_bget?eco:b3344 KEGG_Orthology KO:K07236 http://www.genome.jp/dbget-bin/www_bget?KO:K07236 KEGG_Pathway ko04122 http://www.genome.jp/kegg-bin/show_pathway?ko04122 MINT MINT-1238866 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1238866 OMA MRNYIAT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MRNYIAT PDB 2D1P http://www.ebi.ac.uk/pdbe-srv/view/entry/2D1P PDBsum 2D1P http://www.ebi.ac.uk/pdbsum/2D1P PSORT swissprot:TUSC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TUSC_ECOLI PSORT-B swissprot:TUSC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TUSC_ECOLI PSORT2 swissprot:TUSC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TUSC_ECOLI Pfam PF02635 http://pfam.xfam.org/family/PF02635 Phobius swissprot:TUSC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TUSC_ECOLI ProteinModelPortal P45531 http://www.proteinmodelportal.org/query/uniprot/P45531 PubMed 16387657 http://www.ncbi.nlm.nih.gov/pubmed/16387657 PubMed 16472754 http://www.ncbi.nlm.nih.gov/pubmed/16472754 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417803 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417803 RefSeq WP_000820714 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000820714 SMR P45531 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45531 STRING 511145.b3344 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3344&targetmode=cogs STRING COG2923 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2923&targetmode=cogs SUPFAM SSF75169 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF75169 TIGRFAMs TIGR03010 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03010 UniProtKB TUSC_ECOLI http://www.uniprot.org/uniprot/TUSC_ECOLI UniProtKB-AC P45531 http://www.uniprot.org/uniprot/P45531 charge swissprot:TUSC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TUSC_ECOLI eggNOG COG2923 http://eggnogapi.embl.de/nog_data/html/tree/COG2923 eggNOG ENOG4108ZKU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZKU epestfind swissprot:TUSC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TUSC_ECOLI garnier swissprot:TUSC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TUSC_ECOLI helixturnhelix swissprot:TUSC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TUSC_ECOLI hmoment swissprot:TUSC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TUSC_ECOLI iep swissprot:TUSC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TUSC_ECOLI inforesidue swissprot:TUSC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TUSC_ECOLI octanol swissprot:TUSC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TUSC_ECOLI pepcoil swissprot:TUSC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TUSC_ECOLI pepdigest swissprot:TUSC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TUSC_ECOLI pepinfo swissprot:TUSC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TUSC_ECOLI pepnet swissprot:TUSC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TUSC_ECOLI pepstats swissprot:TUSC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TUSC_ECOLI pepwheel swissprot:TUSC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TUSC_ECOLI pepwindow swissprot:TUSC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TUSC_ECOLI sigcleave swissprot:TUSC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TUSC_ECOLI ## Database ID URL or Descriptions # BRENDA 3.5.1.96 2026 # BioGrid 4262239 18 # CATALYTIC ACTIVITY ASTE_ECOLI N-succinyl-L-glutamate + H(2)O = succinate + L-glutamate. # CDD cd03855 M14_ASTE # COFACTOR ASTE_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000250}; Note=Binds 1 zinc ion per subunit. {ECO 0000250}; # EcoGene EG13995 astE # FUNCTION ASTE_ECOLI Transforms N(2)-succinylglutamate into succinate and glutamate. {ECO 0000269|PubMed 9696779}. # GO_function GO:0008270 zinc ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0009017 succinylglutamate desuccinylase activity; IDA:EcoCyc. # GO_function GO:0016788 hydrolase activity, acting on ester bonds; IEA:UniProtKB-HAMAP. # GO_process GO:0019544 arginine catabolic process to glutamate; IEA:UniProtKB-HAMAP. # GO_process GO:0019545 arginine catabolic process to succinate; IEA:UniProtKB-UniPathway. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # HAMAP MF_00767 Arg_catab_AstE # INDUCTION By nitrogen starvation, and arginine. Induced at stationary phase by sigma S. {ECO:0000269|PubMed 12003934}. # INTERACTION ASTE_ECOLI P0ACS9 acrR; NbExp=3; IntAct=EBI-1121806, EBI-1117360; # IntAct P76215 10 # InterPro IPR007036 Aste_AspA # InterPro IPR016681 SuccinylGlu_desuccinylase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00330 Arginine and proline metabolism # Organism ASTE_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine step 5/5. # PATRIC 32118797 VBIEscCol129921_1816 # PDB 1YW6 X-ray; 3.10 A; A/B=1-322 # PIR H64933 H64933 # PIRSF PIRSF017020 AstE # Pfam PF04952 AstE_AspA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ASTE_ECOLI Succinylglutamate desuccinylase # RefSeq NP_416258 NC_000913.3 # RefSeq WP_000368506 NZ_LN832404.1 # SIMILARITY Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily. {ECO 0000305}. # TIGRFAMs TIGR03242 arg_catab_astE # UniPathway UPA00185 UER00283 # eggNOG COG2988 LUCA # eggNOG ENOG4107UI5 Bacteria BLAST swissprot:ASTE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ASTE_ECOLI BioCyc ECOL316407:JW1733-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1733-MONOMER BioCyc EcoCyc:SUCCGLUDESUCC-MONOMER http://biocyc.org/getid?id=EcoCyc:SUCCGLUDESUCC-MONOMER BioCyc MetaCyc:SUCCGLUDESUCC-MONOMER http://biocyc.org/getid?id=MetaCyc:SUCCGLUDESUCC-MONOMER COG COG2988 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2988 DOI 10.1006/jmbi.1999.3059 http://dx.doi.org/10.1006/jmbi.1999.3059 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.11.2940-2950.2002 http://dx.doi.org/10.1128/JB.184.11.2940-2950.2002 EC_number EC:3.5.1.96 http://www.genome.jp/dbget-bin/www_bget?EC:3.5.1.96 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.5.1.96 http://enzyme.expasy.org/EC/3.5.1.96 EchoBASE EB3751 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3751 EcoGene EG13995 http://www.ecogene.org/geneInfo.php?eg_id=EG13995 EnsemblBacteria AAC74814 http://www.ensemblgenomes.org/id/AAC74814 EnsemblBacteria AAC74814 http://www.ensemblgenomes.org/id/AAC74814 EnsemblBacteria BAE76515 http://www.ensemblgenomes.org/id/BAE76515 EnsemblBacteria BAE76515 http://www.ensemblgenomes.org/id/BAE76515 EnsemblBacteria BAE76515 http://www.ensemblgenomes.org/id/BAE76515 EnsemblBacteria b1744 http://www.ensemblgenomes.org/id/b1744 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0009017 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009017 GO_function GO:0016788 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016788 GO_process GO:0019544 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019544 GO_process GO:0019545 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019545 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GeneID 946256 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946256 HAMAP MF_00767 http://hamap.expasy.org/unirule/MF_00767 HOGENOM HOG000280300 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000280300&db=HOGENOM6 InParanoid P76215 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76215 IntAct P76215 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76215* IntEnz 3.5.1.96 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.1.96 InterPro IPR007036 http://www.ebi.ac.uk/interpro/entry/IPR007036 InterPro IPR016681 http://www.ebi.ac.uk/interpro/entry/IPR016681 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1733 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1733 KEGG_Gene eco:b1744 http://www.genome.jp/dbget-bin/www_bget?eco:b1744 KEGG_Orthology KO:K05526 http://www.genome.jp/dbget-bin/www_bget?KO:K05526 KEGG_Pathway ko00330 http://www.genome.jp/kegg-bin/show_pathway?ko00330 KEGG_Reaction rn:R00411 http://www.genome.jp/dbget-bin/www_bget?rn:R00411 OMA AHAFTVE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AHAFTVE PDB 1YW6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1YW6 PDBsum 1YW6 http://www.ebi.ac.uk/pdbsum/1YW6 PSORT swissprot:ASTE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ASTE_ECOLI PSORT-B swissprot:ASTE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ASTE_ECOLI PSORT2 swissprot:ASTE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ASTE_ECOLI Pfam PF04952 http://pfam.xfam.org/family/PF04952 Phobius swissprot:ASTE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ASTE_ECOLI ProteinModelPortal P76215 http://www.proteinmodelportal.org/query/uniprot/P76215 PubMed 10493853 http://www.ncbi.nlm.nih.gov/pubmed/10493853 PubMed 12003934 http://www.ncbi.nlm.nih.gov/pubmed/12003934 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9068658 http://www.ncbi.nlm.nih.gov/pubmed/9068658 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9696779 http://www.ncbi.nlm.nih.gov/pubmed/9696779 RefSeq NP_416258 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416258 RefSeq WP_000368506 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000368506 SMR P76215 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76215 STRING 511145.b1744 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1744&targetmode=cogs STRING COG2988 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2988&targetmode=cogs TIGRFAMs TIGR03242 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03242 UniProtKB ASTE_ECOLI http://www.uniprot.org/uniprot/ASTE_ECOLI UniProtKB-AC P76215 http://www.uniprot.org/uniprot/P76215 charge swissprot:ASTE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ASTE_ECOLI eggNOG COG2988 http://eggnogapi.embl.de/nog_data/html/tree/COG2988 eggNOG ENOG4107UI5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107UI5 epestfind swissprot:ASTE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ASTE_ECOLI garnier swissprot:ASTE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ASTE_ECOLI helixturnhelix swissprot:ASTE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ASTE_ECOLI hmoment swissprot:ASTE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ASTE_ECOLI iep swissprot:ASTE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ASTE_ECOLI inforesidue swissprot:ASTE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ASTE_ECOLI octanol swissprot:ASTE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ASTE_ECOLI pepcoil swissprot:ASTE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ASTE_ECOLI pepdigest swissprot:ASTE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ASTE_ECOLI pepinfo swissprot:ASTE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ASTE_ECOLI pepnet swissprot:ASTE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ASTE_ECOLI pepstats swissprot:ASTE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ASTE_ECOLI pepwheel swissprot:ASTE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ASTE_ECOLI pepwindow swissprot:ASTE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ASTE_ECOLI sigcleave swissprot:ASTE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ASTE_ECOLI ## Database ID URL or Descriptions # AltName ATPL_ECOLI ATP synthase F(0) sector subunit c # AltName ATPL_ECOLI Dicyclohexylcarbodiimide-binding protein # AltName ATPL_ECOLI F-type ATPase subunit c # AltName ATPL_ECOLI Lipid-binding protein # EcoGene EG10102 atpE # FUNCTION ATPL_ECOLI F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. # FUNCTION ATPL_ECOLI Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of 10 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IDA:EcoliWiki. # GO_component GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o); IMP:EcoliWiki. # GO_function GO:0008289 lipid binding; IEA:UniProtKB-KW. # GO_function GO:0046933 proton-transporting ATP synthase activity, rotational mechanism; IMP:EcoCyc. # GO_function GO:0046961 proton-transporting ATPase activity, rotational mechanism; IMP:EcoCyc. # GO_process GO:0015986 ATP synthesis coupled proton transport; IBA:GO_Central. # GO_process GO:0015991 ATP hydrolysis coupled proton transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0008289 lipid binding # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0055085 transmembrane transport # Gene3D 1.20.20.10 -; 1. # HAMAP MF_01396 ATP_synth_c_bact # IntAct P68699 3 # InterPro IPR000454 ATP_synth_F0_csu # InterPro IPR002379 ATPase_proteolipid_c-like_dom # InterPro IPR005953 ATP_synth_csu_bac/chlpt # InterPro IPR020537 ATP_synth_F0_csu_DDCD_BS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko00194 Photosynthesis proteins # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00190 Oxidative phosphorylation # KEGG_Pathway ko00195 Photosynthesis # MISCELLANEOUS ATPL_ECOLI Dicyclohexylcarbodiimide (DCDD) binding to the reversibly protonated aspartate residue inhibits ATPase in vitro. # MISCELLANEOUS In this organism c-rings of between c(8) and c(12) can be isolated in vivo following experimental manipulations, however only c(8) and c(9), in addition to c(10), are partially functional. {ECO:0000305|PubMed 11320246}. # Organism ATPL_ECOLI Escherichia coli (strain K12) # PATRIC 32122971 VBIEscCol129921_3861 # PDB 1A91 NMR; -; A=1-79 # PDB 1ATY NMR; -; A=1-79 # PDB 1C0V NMR; -; A=1-79 # PDB 1C17 NMR; -; A/B/C/D/E/F/G/H/I/J/K/L=1-79 # PDB 1C99 NMR; -; A=1-79 # PDB 1IJP NMR; -; A=1-79 # PDB 1J7F Model; -; A/B/C/D/E/F/G/H/I/J/K/L=1-79 # PDB 1L6T NMR; -; A=1-79 # PDB 1QO1 X-ray; 3.90 A; K/L/M/N/O/P/Q/R/S/T=1-79 # PDB 4UTQ EM; 8.00 A; Z=1-79 # PIR B93732 LWECA # PRINTS PR00124 ATPASEC # PROSITE PS00605 ATPASE_C # Pfam PF00137 ATP-synt_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ATPL_ECOLI ATP synthase subunit c # RefSeq NP_418193 NC_000913.3 # RefSeq WP_000429386 NZ_LN832404.1 # SIMILARITY Belongs to the ATPase C chain family. {ECO 0000305}. # SUBCELLULAR LOCATION ATPL_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # SUBUNIT ATPL_ECOLI F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits a(1), b(2) and c(10). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains. {ECO 0000269|PubMed 11320246}. # SUPFAM SSF81333 SSF81333 # TCDB 3.A.2.1 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily # TIGRFAMs TIGR01260 ATP_synt_c # eggNOG COG0636 LUCA BLAST swissprot:ATPL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ATPL_ECOLI BioCyc ECOL316407:JW3715-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3715-MONOMER BioCyc EcoCyc:ATPE-MONOMER http://biocyc.org/getid?id=EcoCyc:ATPE-MONOMER BioCyc MetaCyc:ATPE-MONOMER http://biocyc.org/getid?id=MetaCyc:ATPE-MONOMER COG COG0636 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0636 DIP DIP-2198N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-2198N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1007/BF00271191 http://dx.doi.org/10.1007/BF00271191 DOI 10.1016/0014-5793(80)80606-5 http://dx.doi.org/10.1016/0014-5793(80)80606-5 DOI 10.1016/S0006-291X(81)80085-X http://dx.doi.org/10.1016/S0006-291X(81)80085-X DOI 10.1016/S0014-5793(97)00529-2 http://dx.doi.org/10.1016/S0014-5793(97)00529-2 DOI 10.1021/bi00005a020 http://dx.doi.org/10.1021/bi00005a020 DOI 10.1021/bi00142a017 http://dx.doi.org/10.1021/bi00142a017 DOI 10.1021/bi980511m http://dx.doi.org/10.1021/bi980511m DOI 10.1038/46224 http://dx.doi.org/10.1038/46224 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2110717 http://dx.doi.org/10.1042/bj2110717 DOI 10.1042/bj2130451 http://dx.doi.org/10.1042/bj2130451 DOI 10.1042/bj2240799 http://dx.doi.org/10.1042/bj2240799 DOI 10.1073/pnas.081424898 http://dx.doi.org/10.1073/pnas.081424898 DOI 10.1093/nar/9.16.3919 http://dx.doi.org/10.1093/nar/9.16.3919 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01594 http://www.ebi.ac.uk/ena/data/view/J01594 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M12214 http://www.ebi.ac.uk/ena/data/view/M12214 EMBL M25464 http://www.ebi.ac.uk/ena/data/view/M25464 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00264 http://www.ebi.ac.uk/ena/data/view/V00264 EMBL V00266 http://www.ebi.ac.uk/ena/data/view/V00266 EMBL V00310 http://www.ebi.ac.uk/ena/data/view/V00310 EMBL V01506 http://www.ebi.ac.uk/ena/data/view/V01506 EMBL X01631 http://www.ebi.ac.uk/ena/data/view/X01631 EchoBASE EB0100 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0100 EcoGene EG10102 http://www.ecogene.org/geneInfo.php?eg_id=EG10102 EnsemblBacteria AAC76760 http://www.ensemblgenomes.org/id/AAC76760 EnsemblBacteria AAC76760 http://www.ensemblgenomes.org/id/AAC76760 EnsemblBacteria BAE77551 http://www.ensemblgenomes.org/id/BAE77551 EnsemblBacteria BAE77551 http://www.ensemblgenomes.org/id/BAE77551 EnsemblBacteria BAE77551 http://www.ensemblgenomes.org/id/BAE77551 EnsemblBacteria b3737 http://www.ensemblgenomes.org/id/b3737 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0045263 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045263 GO_function GO:0008289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289 GO_function GO:0046933 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046933 GO_function GO:0046961 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046961 GO_process GO:0015986 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015986 GO_process GO:0015991 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015991 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0008289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 1.20.20.10 http://www.cathdb.info/version/latest/superfamily/1.20.20.10 GeneID 5549087 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5549087 GeneID 948253 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948253 HAMAP MF_01396 http://hamap.expasy.org/unirule/MF_01396 HOGENOM HOG000235244 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000235244&db=HOGENOM6 InParanoid P68699 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P68699 IntAct P68699 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P68699* InterPro IPR000454 http://www.ebi.ac.uk/interpro/entry/IPR000454 InterPro IPR002379 http://www.ebi.ac.uk/interpro/entry/IPR002379 InterPro IPR005953 http://www.ebi.ac.uk/interpro/entry/IPR005953 InterPro IPR020537 http://www.ebi.ac.uk/interpro/entry/IPR020537 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko00194 http://www.genome.jp/dbget-bin/www_bget?ko00194 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3715 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3715 KEGG_Gene eco:b3737 http://www.genome.jp/dbget-bin/www_bget?eco:b3737 KEGG_Orthology KO:K02110 http://www.genome.jp/dbget-bin/www_bget?KO:K02110 KEGG_Pathway ko00190 http://www.genome.jp/kegg-bin/show_pathway?ko00190 KEGG_Pathway ko00195 http://www.genome.jp/kegg-bin/show_pathway?ko00195 MINT MINT-8087956 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8087956 OMA MDLLYIA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MDLLYIA PDB 1A91 http://www.ebi.ac.uk/pdbe-srv/view/entry/1A91 PDB 1ATY http://www.ebi.ac.uk/pdbe-srv/view/entry/1ATY PDB 1C0V http://www.ebi.ac.uk/pdbe-srv/view/entry/1C0V PDB 1C17 http://www.ebi.ac.uk/pdbe-srv/view/entry/1C17 PDB 1C99 http://www.ebi.ac.uk/pdbe-srv/view/entry/1C99 PDB 1IJP http://www.ebi.ac.uk/pdbe-srv/view/entry/1IJP PDB 1J7F http://www.ebi.ac.uk/pdbe-srv/view/entry/1J7F PDB 1L6T http://www.ebi.ac.uk/pdbe-srv/view/entry/1L6T PDB 1QO1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1QO1 PDB 4UTQ http://www.ebi.ac.uk/pdbe-srv/view/entry/4UTQ PDBsum 1A91 http://www.ebi.ac.uk/pdbsum/1A91 PDBsum 1ATY http://www.ebi.ac.uk/pdbsum/1ATY PDBsum 1C0V http://www.ebi.ac.uk/pdbsum/1C0V PDBsum 1C17 http://www.ebi.ac.uk/pdbsum/1C17 PDBsum 1C99 http://www.ebi.ac.uk/pdbsum/1C99 PDBsum 1IJP http://www.ebi.ac.uk/pdbsum/1IJP PDBsum 1J7F http://www.ebi.ac.uk/pdbsum/1J7F PDBsum 1L6T http://www.ebi.ac.uk/pdbsum/1L6T PDBsum 1QO1 http://www.ebi.ac.uk/pdbsum/1QO1 PDBsum 4UTQ http://www.ebi.ac.uk/pdbsum/4UTQ PRINTS PR00124 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00124 PROSITE PS00605 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00605 PSORT swissprot:ATPL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ATPL_ECOLI PSORT-B swissprot:ATPL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ATPL_ECOLI PSORT2 swissprot:ATPL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ATPL_ECOLI Pfam PF00137 http://pfam.xfam.org/family/PF00137 Phobius swissprot:ATPL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ATPL_ECOLI ProteinModelPortal P68699 http://www.proteinmodelportal.org/query/uniprot/P68699 PubMed 10580496 http://www.ncbi.nlm.nih.gov/pubmed/10580496 PubMed 11320246 http://www.ncbi.nlm.nih.gov/pubmed/11320246 PubMed 1385726 http://www.ncbi.nlm.nih.gov/pubmed/1385726 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6193778 http://www.ncbi.nlm.nih.gov/pubmed/6193778 PubMed 6266400 http://www.ncbi.nlm.nih.gov/pubmed/6266400 PubMed 6272190 http://www.ncbi.nlm.nih.gov/pubmed/6272190 PubMed 6278247 http://www.ncbi.nlm.nih.gov/pubmed/6278247 PubMed 6309138 http://www.ncbi.nlm.nih.gov/pubmed/6309138 PubMed 6395859 http://www.ncbi.nlm.nih.gov/pubmed/6395859 PubMed 6446460 http://www.ncbi.nlm.nih.gov/pubmed/6446460 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 7849023 http://www.ncbi.nlm.nih.gov/pubmed/7849023 PubMed 9237612 http://www.ncbi.nlm.nih.gov/pubmed/9237612 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9636021 http://www.ncbi.nlm.nih.gov/pubmed/9636021 RefSeq NP_418193 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418193 RefSeq WP_000429386 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000429386 SMR P68699 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P68699 STRING 511145.b3737 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3737&targetmode=cogs STRING COG0636 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0636&targetmode=cogs SUPFAM SSF81333 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81333 TCDB 3.A.2.1 http://www.tcdb.org/search/result.php?tc=3.A.2.1 TIGRFAMs TIGR01260 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01260 UniProtKB ATPL_ECOLI http://www.uniprot.org/uniprot/ATPL_ECOLI UniProtKB-AC P68699 http://www.uniprot.org/uniprot/P68699 charge swissprot:ATPL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ATPL_ECOLI eggNOG COG0636 http://eggnogapi.embl.de/nog_data/html/tree/COG0636 epestfind swissprot:ATPL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ATPL_ECOLI garnier swissprot:ATPL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ATPL_ECOLI helixturnhelix swissprot:ATPL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ATPL_ECOLI hmoment swissprot:ATPL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ATPL_ECOLI iep swissprot:ATPL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ATPL_ECOLI inforesidue swissprot:ATPL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ATPL_ECOLI octanol swissprot:ATPL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ATPL_ECOLI pepcoil swissprot:ATPL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ATPL_ECOLI pepdigest swissprot:ATPL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ATPL_ECOLI pepinfo swissprot:ATPL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ATPL_ECOLI pepnet swissprot:ATPL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ATPL_ECOLI pepstats swissprot:ATPL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ATPL_ECOLI pepwheel swissprot:ATPL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ATPL_ECOLI pepwindow swissprot:ATPL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ATPL_ECOLI sigcleave swissprot:ATPL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ATPL_ECOLI ## Database ID URL or Descriptions # BioGrid 4262292 4 # EcoGene EG13124 ygcQ # FUNCTION YGCQ_ECOLI May play a role in a redox process. # GO_function GO:0009055 electron carrier activity; IEA:InterPro. # GO_function GO:0050660 flavin adenine dinucleotide binding; IEA:InterPro. # GO_process GO:0055114 oxidation-reduction process; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.1220 -; 1. # Gene3D 3.40.50.620 -; 1. # IntAct Q46907 2 # InterPro IPR001308 ETF_a/FixB # InterPro IPR014729 Rossmann-like_a/b/a_fold # InterPro IPR014730 ETF_a/b_N # InterPro IPR014731 ETF_asu_C # InterPro IPR029035 DHS-like_NAD/FAD-binding_dom # Organism YGCQ_ECOLI Escherichia coli (strain K12) # PATRIC 32120950 VBIEscCol129921_2867 # PIR E65058 E65058 # PIRSF PIRSF000089 Electra_flavoP_a # Pfam PF00766 ETF_alpha # Pfam PF01012 ETF # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGCQ_ECOLI Putative electron transfer flavoprotein subunit YgcQ # RefSeq NP_417249 NC_000913.3 # RefSeq WP_001299097 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA69279.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ETF alpha-subunit/FixB family. {ECO 0000305}. # SUBUNIT YgcQ and YgcR form a heterodimer. {ECO 0000305}. # SUPFAM SSF52467 SSF52467 # eggNOG COG2025 LUCA # eggNOG ENOG4105YBM Bacteria BLAST swissprot:YGCQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGCQ_ECOLI BioCyc ECOL316407:JW5440-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5440-MONOMER BioCyc EcoCyc:G7435-MONOMER http://biocyc.org/getid?id=EcoCyc:G7435-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EchoBASE EB2925 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2925 EcoGene EG13124 http://www.ecogene.org/geneInfo.php?eg_id=EG13124 EnsemblBacteria AAC75811 http://www.ensemblgenomes.org/id/AAC75811 EnsemblBacteria AAC75811 http://www.ensemblgenomes.org/id/AAC75811 EnsemblBacteria BAE76846 http://www.ensemblgenomes.org/id/BAE76846 EnsemblBacteria BAE76846 http://www.ensemblgenomes.org/id/BAE76846 EnsemblBacteria BAE76846 http://www.ensemblgenomes.org/id/BAE76846 EnsemblBacteria b2769 http://www.ensemblgenomes.org/id/b2769 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_process GO:0055114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.1220 http://www.cathdb.info/version/latest/superfamily/3.40.50.1220 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 GeneID 946413 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946413 HOGENOM HOG000124102 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000124102&db=HOGENOM6 InParanoid Q46907 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46907 IntAct Q46907 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46907* InterPro IPR001308 http://www.ebi.ac.uk/interpro/entry/IPR001308 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 InterPro IPR014730 http://www.ebi.ac.uk/interpro/entry/IPR014730 InterPro IPR014731 http://www.ebi.ac.uk/interpro/entry/IPR014731 InterPro IPR029035 http://www.ebi.ac.uk/interpro/entry/IPR029035 KEGG_Gene ecj:JW5440 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5440 KEGG_Gene eco:b2769 http://www.genome.jp/dbget-bin/www_bget?eco:b2769 OMA ISTIECQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ISTIECQ PSORT swissprot:YGCQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGCQ_ECOLI PSORT-B swissprot:YGCQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGCQ_ECOLI PSORT2 swissprot:YGCQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGCQ_ECOLI Pfam PF00766 http://pfam.xfam.org/family/PF00766 Pfam PF01012 http://pfam.xfam.org/family/PF01012 Phobius swissprot:YGCQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGCQ_ECOLI PhylomeDB Q46907 http://phylomedb.org/?seqid=Q46907 ProteinModelPortal Q46907 http://www.proteinmodelportal.org/query/uniprot/Q46907 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417249 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417249 RefSeq WP_001299097 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001299097 STRING 511145.b2769 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2769&targetmode=cogs SUPFAM SSF52467 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52467 UniProtKB YGCQ_ECOLI http://www.uniprot.org/uniprot/YGCQ_ECOLI UniProtKB-AC Q46907 http://www.uniprot.org/uniprot/Q46907 charge swissprot:YGCQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGCQ_ECOLI eggNOG COG2025 http://eggnogapi.embl.de/nog_data/html/tree/COG2025 eggNOG ENOG4105YBM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105YBM epestfind swissprot:YGCQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGCQ_ECOLI garnier swissprot:YGCQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGCQ_ECOLI helixturnhelix swissprot:YGCQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGCQ_ECOLI hmoment swissprot:YGCQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGCQ_ECOLI iep swissprot:YGCQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGCQ_ECOLI inforesidue swissprot:YGCQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGCQ_ECOLI octanol swissprot:YGCQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGCQ_ECOLI pepcoil swissprot:YGCQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGCQ_ECOLI pepdigest swissprot:YGCQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGCQ_ECOLI pepinfo swissprot:YGCQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGCQ_ECOLI pepnet swissprot:YGCQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGCQ_ECOLI pepstats swissprot:YGCQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGCQ_ECOLI pepwheel swissprot:YGCQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGCQ_ECOLI pepwindow swissprot:YGCQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGCQ_ECOLI sigcleave swissprot:YGCQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGCQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4259973 6 # CATALYTIC ACTIVITY DPS_ECOLI 2 Fe(2+) + H(2)O(2) + 2 H(+) = 2 Fe(3+) + 2 H(2)O. # CDD cd01043 DPS # DOMAIN DPS_ECOLI 12 dinuclear ferroxidase centers are located at the interfaces between subunits related by 2-fold symmetry axes. The lysine-rich N-terminus is required for self-aggregation as well as for dps-driven DNA condensation. # EcoGene EG11415 dps # FUNCTION DPS_ECOLI During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction. Dps also protects the cell from UV and gamma irradiation, iron and copper toxicity, thermal stress and acid and base shocks. Also shows a weak catalase activity. {ECO 0000269|PubMed 10403254, ECO 0000269|PubMed 1340475, ECO 0000269|PubMed 15205421, ECO 0000269|PubMed 15534364}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-HAMAP. # GO_component GO:0009295 nucleoid; IEA:UniProtKB-SubCell. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0003677 DNA binding; IDA:EcoliWiki. # GO_function GO:0008199 ferric iron binding; IEA:UniProtKB-HAMAP. # GO_function GO:0016722 oxidoreductase activity, oxidizing metal ions; IEA:InterPro. # GO_process GO:0006879 cellular iron ion homeostasis; IEA:UniProtKB-KW. # GO_process GO:0030261 chromosome condensation; IEA:UniProtKB-KW. # GO_process GO:0042594 response to starvation; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0042592 homeostatic process # GOslim_process GO:0051276 chromosome organization # Gene3D 1.20.1260.10 -; 1. # HAMAP MF_01441 Dps # INDUCTION Induced by RpoS and IHF in the early stationary phase. Induced by OxyR in response to oxidative stress during exponential phase. ClpXP probably directly regulate proteolysis of dps during exponential phase. ClpAP seems to play an indirect role in maintaining ongoing dps synthesis during stationary phase. {ECO:0000269|PubMed 7984106}. # INTERACTION DPS_ECOLI P0A8Q6 clpS; NbExp=5; IntAct=EBI-549640, EBI-561456; P03004 dnaA; NbExp=2; IntAct=EBI-549640, EBI-548951; # IntAct P0ABT2 31 # InterPro IPR002177 DPS_DNA-bd # InterPro IPR008331 Ferritin_DPS_dom # InterPro IPR009078 Ferritin-like_SF # InterPro IPR012347 Ferritin-rel # InterPro IPR023067 Dps_gammaproteobac # InterPro IPR023188 DPS_DNA-bd_CS # KEGG_Brite ko03036 Chromosome # Organism DPS_ECOLI Escherichia coli (strain K12) # PATRIC 32116827 VBIEscCol129921_0839 # PDB 1DPS X-ray; 1.60 A; A/B/C/D/E/F/G/H/I/J/K/L=1-167 # PDB 1F30 X-ray; 2.85 A; A/B/C/D/E/F/G/H/I/J/K/L=1-167 # PDB 1F33 X-ray; 2.60 A; A/B/C/D/E/F/G/H/I/J/K/L=1-167 # PDB 1JRE X-ray; 2.65 A; A/B/C/D/E/F/G/H/I/J/K/L=1-167 # PDB 1JTS X-ray; 2.60 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=1-167 # PDB 1L8H X-ray; 3.20 A; A/B/C/D/E/F/G/H/I/J/K/L=1-167 # PDB 1L8I X-ray; 3.00 A; A/B/C/D/E/F/G/H/I/J/K/L=1-167 # PDB 2W9R X-ray; 1.70 A; B=6-16 # PDB 3O2H X-ray; 1.70 A; B=6-16 # PIR A46401 A46401 # PIRSF PIRSF005900 Dps # PRINTS PR01346 HELNAPAPROT # PROSITE PS00818 DPS_1 # PROSITE PS00819 DPS_2 # Pfam PF00210 Ferritin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DPS_ECOLI DNA protection during starvation protein # RefSeq NP_415333 NC_000913.3 # RefSeq WP_000100800 NZ_LN832404.1 # SIMILARITY Belongs to the Dps family. {ECO 0000305}. # SUBCELLULAR LOCATION DPS_ECOLI Cytoplasm, nucleoid. # SUBUNIT Homododecamer. The 12 subunits form a hollow sphere into which the mineral iron core of up to 500 Fe(3+) can be deposited. {ECO:0000269|PubMed 9546221, ECO:0000269|Ref.20}. # SUPFAM SSF47240 SSF47240 # eggNOG COG0783 LUCA # eggNOG ENOG4105DPV Bacteria BLAST swissprot:DPS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DPS_ECOLI BioCyc ECOL316407:JW0797-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0797-MONOMER BioCyc EcoCyc:EG11415-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11415-MONOMER COG COG0783 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0783 DIP DIP-35919N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35919N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1007/BF00430437 http://dx.doi.org/10.1007/BF00430437 DOI 10.1038/21918 http://dx.doi.org/10.1038/21918 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb0498-294 http://dx.doi.org/10.1038/nsb0498-294 DOI 10.1046/j.1365-2958.2003.03644.x http://dx.doi.org/10.1046/j.1365-2958.2003.03644.x DOI 10.1074/jbc.273.33.21393 http://dx.doi.org/10.1074/jbc.273.33.21393 DOI 10.1074/jbc.M202094200 http://dx.doi.org/10.1074/jbc.M202094200 DOI 10.1074/jbc.M206186200 http://dx.doi.org/10.1074/jbc.M206186200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/gkh915 http://dx.doi.org/10.1093/nar/gkh915 DOI 10.1101/gad.6.12b.2646 http://dx.doi.org/10.1101/gad.6.12b.2646 DOI 10.1111/j.1365-2958.1994.tb00421.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb00421.x DOI 10.1111/j.1574-6968.1993.tb06338.x http://dx.doi.org/10.1111/j.1574-6968.1993.tb06338.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.186.13.4192-4198.2004 http://dx.doi.org/10.1128/JB.186.13.4192-4198.2004 EC_number EC:1.16.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.16.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U04242 http://www.ebi.ac.uk/ena/data/view/U04242 EMBL X14180 http://www.ebi.ac.uk/ena/data/view/X14180 EMBL X69337 http://www.ebi.ac.uk/ena/data/view/X69337 ENZYME 1.16.-.- http://enzyme.expasy.org/EC/1.16.-.- EchoBASE EB1387 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1387 EcoGene EG11415 http://www.ecogene.org/geneInfo.php?eg_id=EG11415 EnsemblBacteria AAC73899 http://www.ensemblgenomes.org/id/AAC73899 EnsemblBacteria AAC73899 http://www.ensemblgenomes.org/id/AAC73899 EnsemblBacteria BAA35484 http://www.ensemblgenomes.org/id/BAA35484 EnsemblBacteria BAA35484 http://www.ensemblgenomes.org/id/BAA35484 EnsemblBacteria BAA35484 http://www.ensemblgenomes.org/id/BAA35484 EnsemblBacteria b0812 http://www.ensemblgenomes.org/id/b0812 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0009295 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009295 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0008199 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008199 GO_function GO:0016722 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016722 GO_process GO:0006879 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006879 GO_process GO:0030261 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030261 GO_process GO:0042594 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042594 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GOslim_process GO:0051276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051276 Gene3D 1.20.1260.10 http://www.cathdb.info/version/latest/superfamily/1.20.1260.10 GeneID 945101 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945101 HAMAP MF_01441 http://hamap.expasy.org/unirule/MF_01441 HOGENOM HOG000273542 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000273542&db=HOGENOM6 InParanoid P0ABT2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABT2 IntAct P0ABT2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABT2* IntEnz 1.16 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.16 InterPro IPR002177 http://www.ebi.ac.uk/interpro/entry/IPR002177 InterPro IPR008331 http://www.ebi.ac.uk/interpro/entry/IPR008331 InterPro IPR009078 http://www.ebi.ac.uk/interpro/entry/IPR009078 InterPro IPR012347 http://www.ebi.ac.uk/interpro/entry/IPR012347 InterPro IPR023067 http://www.ebi.ac.uk/interpro/entry/IPR023067 InterPro IPR023188 http://www.ebi.ac.uk/interpro/entry/IPR023188 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene ecj:JW0797 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0797 KEGG_Gene eco:b0812 http://www.genome.jp/dbget-bin/www_bget?eco:b0812 KEGG_Orthology KO:K04047 http://www.genome.jp/dbget-bin/www_bget?KO:K04047 MINT MINT-1220368 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1220368 OMA DIHSVQD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DIHSVQD PDB 1DPS http://www.ebi.ac.uk/pdbe-srv/view/entry/1DPS PDB 1F30 http://www.ebi.ac.uk/pdbe-srv/view/entry/1F30 PDB 1F33 http://www.ebi.ac.uk/pdbe-srv/view/entry/1F33 PDB 1JRE http://www.ebi.ac.uk/pdbe-srv/view/entry/1JRE PDB 1JTS http://www.ebi.ac.uk/pdbe-srv/view/entry/1JTS PDB 1L8H http://www.ebi.ac.uk/pdbe-srv/view/entry/1L8H PDB 1L8I http://www.ebi.ac.uk/pdbe-srv/view/entry/1L8I PDB 2W9R http://www.ebi.ac.uk/pdbe-srv/view/entry/2W9R PDB 3O2H http://www.ebi.ac.uk/pdbe-srv/view/entry/3O2H PDBsum 1DPS http://www.ebi.ac.uk/pdbsum/1DPS PDBsum 1F30 http://www.ebi.ac.uk/pdbsum/1F30 PDBsum 1F33 http://www.ebi.ac.uk/pdbsum/1F33 PDBsum 1JRE http://www.ebi.ac.uk/pdbsum/1JRE PDBsum 1JTS http://www.ebi.ac.uk/pdbsum/1JTS PDBsum 1L8H http://www.ebi.ac.uk/pdbsum/1L8H PDBsum 1L8I http://www.ebi.ac.uk/pdbsum/1L8I PDBsum 2W9R http://www.ebi.ac.uk/pdbsum/2W9R PDBsum 3O2H http://www.ebi.ac.uk/pdbsum/3O2H PRINTS PR01346 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01346 PROSITE PS00818 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00818 PROSITE PS00819 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00819 PSORT swissprot:DPS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DPS_ECOLI PSORT-B swissprot:DPS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DPS_ECOLI PSORT2 swissprot:DPS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DPS_ECOLI Pfam PF00210 http://pfam.xfam.org/family/PF00210 Phobius swissprot:DPS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DPS_ECOLI PhylomeDB P0ABT2 http://phylomedb.org/?seqid=P0ABT2 ProteinModelPortal P0ABT2 http://www.proteinmodelportal.org/query/uniprot/P0ABT2 PubMed 10403254 http://www.ncbi.nlm.nih.gov/pubmed/10403254 PubMed 12016214 http://www.ncbi.nlm.nih.gov/pubmed/12016214 PubMed 12163499 http://www.ncbi.nlm.nih.gov/pubmed/12163499 PubMed 12950924 http://www.ncbi.nlm.nih.gov/pubmed/12950924 PubMed 1340475 http://www.ncbi.nlm.nih.gov/pubmed/1340475 PubMed 15205421 http://www.ncbi.nlm.nih.gov/pubmed/15205421 PubMed 15534364 http://www.ncbi.nlm.nih.gov/pubmed/15534364 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3027504 http://www.ncbi.nlm.nih.gov/pubmed/3027504 PubMed 7984106 http://www.ncbi.nlm.nih.gov/pubmed/7984106 PubMed 8021175 http://www.ncbi.nlm.nih.gov/pubmed/8021175 PubMed 8354462 http://www.ncbi.nlm.nih.gov/pubmed/8354462 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9546221 http://www.ncbi.nlm.nih.gov/pubmed/9546221 PubMed 9694902 http://www.ncbi.nlm.nih.gov/pubmed/9694902 RefSeq NP_415333 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415333 RefSeq WP_000100800 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000100800 SMR P0ABT2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABT2 STRING 511145.b0812 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0812&targetmode=cogs STRING COG0783 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0783&targetmode=cogs SUPFAM SSF47240 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47240 SWISS-2DPAGE P0ABT2 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0ABT2 UniProtKB DPS_ECOLI http://www.uniprot.org/uniprot/DPS_ECOLI UniProtKB-AC P0ABT2 http://www.uniprot.org/uniprot/P0ABT2 charge swissprot:DPS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DPS_ECOLI eggNOG COG0783 http://eggnogapi.embl.de/nog_data/html/tree/COG0783 eggNOG ENOG4105DPV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DPV epestfind swissprot:DPS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DPS_ECOLI garnier swissprot:DPS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DPS_ECOLI helixturnhelix swissprot:DPS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DPS_ECOLI hmoment swissprot:DPS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DPS_ECOLI iep swissprot:DPS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DPS_ECOLI inforesidue swissprot:DPS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DPS_ECOLI octanol swissprot:DPS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DPS_ECOLI pepcoil swissprot:DPS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DPS_ECOLI pepdigest swissprot:DPS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DPS_ECOLI pepinfo swissprot:DPS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DPS_ECOLI pepnet swissprot:DPS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DPS_ECOLI pepstats swissprot:DPS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DPS_ECOLI pepwheel swissprot:DPS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DPS_ECOLI pepwindow swissprot:DPS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DPS_ECOLI sigcleave swissprot:DPS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DPS_ECOLI ## Database ID URL or Descriptions # BioGrid 4262884 12 # DISRUPTION PHENOTYPE Partial loss of Obg-controlled persistence. {ECO:0000269|PubMed 26051177}. # EcoGene EG11240 hokB # FUNCTION HOKB_ECOLI Toxic component of a type I toxin-antitoxin (TA) module. Its toxic effects are probably neutralized by sRNA antitoxin sokB, which is encoded in trans on the opposite DNA strand (Probable). Expression leads to membrane depolarization; when protein levels are high enough depolarization probably leads to lowered metabolic activity which in turn induces some cells to enter the persistent state in which they transiently survive antibiotic exposure. {ECO 0000269|PubMed 26051177, ECO 0000305}. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0022611 dormancy process; IDA:UniProtKB. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0008150 biological_process # INDUCTION Induced by GTPase Obg expression, which requires alarmone (p)ppGpp. {ECO:0000269|PubMed 26051177}. # InterPro IPR000021 Hok/gef_toxin # InterPro IPR018084 Hok/gef_toxin_CS # Organism HOKB_ECOLI Escherichia coli (strain K12) # PRINTS PR00281 HOKGEFTOXIC # PROSITE PS00556 HOK_GEF # Pfam PF01848 HOK_GEF # ProDom PD005979 Hok/gef_toxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Toxin HokB {ECO 0000305} # RefSeq WP_001320773 NZ_LN832404.1 # RefSeq YP_025301 NC_000913.3 # SIMILARITY Belongs to the hok/gef family. {ECO 0000305}. # SUBCELLULAR LOCATION HOKB_ECOLI Membrane {ECO 0000305|PubMed 26051177}; Single-pass membrane protein {ECO 0000255}. # TCDB 1.E.53.1 the toxic hok/gef protein (hok/gef) family # eggNOG ENOG4107NK6 Bacteria # eggNOG ENOG410ZT31 LUCA BLAST swissprot:HOKB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HOKB_ECOLI BioCyc ECOL316407:JW5225-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5225-MONOMER BioCyc EcoCyc:MONOMER0-1604 http://biocyc.org/getid?id=EcoCyc:MONOMER0-1604 DOI 10.1016/j.molcel.2015.05.011 http://dx.doi.org/10.1016/j.molcel.2015.05.011 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1999.01431.x http://dx.doi.org/10.1046/j.1365-2958.1999.01431.x DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1222 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1222 EcoGene EG11240 http://www.ecogene.org/geneInfo.php?eg_id=EG11240 EnsemblBacteria AAT48130 http://www.ensemblgenomes.org/id/AAT48130 EnsemblBacteria AAT48130 http://www.ensemblgenomes.org/id/AAT48130 EnsemblBacteria BAA15042 http://www.ensemblgenomes.org/id/BAA15042 EnsemblBacteria BAA15042 http://www.ensemblgenomes.org/id/BAA15042 EnsemblBacteria BAA15042 http://www.ensemblgenomes.org/id/BAA15042 EnsemblBacteria b4428 http://www.ensemblgenomes.org/id/b4428 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0022611 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022611 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 2847727 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2847727 HOGENOM HOG000041219 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000041219&db=HOGENOM6 InterPro IPR000021 http://www.ebi.ac.uk/interpro/entry/IPR000021 InterPro IPR018084 http://www.ebi.ac.uk/interpro/entry/IPR018084 KEGG_Gene ecj:JW5225 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5225 KEGG_Gene eco:b4428 http://www.genome.jp/dbget-bin/www_bget?eco:b4428 PRINTS PR00281 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00281 PROSITE PS00556 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00556 PSORT swissprot:HOKB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HOKB_ECOLI PSORT-B swissprot:HOKB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HOKB_ECOLI PSORT2 swissprot:HOKB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HOKB_ECOLI Pfam PF01848 http://pfam.xfam.org/family/PF01848 Phobius swissprot:HOKB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HOKB_ECOLI ProteinModelPortal P77494 http://www.proteinmodelportal.org/query/uniprot/P77494 PubMed 10361310 http://www.ncbi.nlm.nih.gov/pubmed/10361310 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 26051177 http://www.ncbi.nlm.nih.gov/pubmed/26051177 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001320773 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001320773 RefSeq YP_025301 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_025301 STRING 511145.b4428 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4428&targetmode=cogs TCDB 1.E.53.1 http://www.tcdb.org/search/result.php?tc=1.E.53.1 UniProtKB HOKB_ECOLI http://www.uniprot.org/uniprot/HOKB_ECOLI UniProtKB-AC P77494 http://www.uniprot.org/uniprot/P77494 charge swissprot:HOKB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HOKB_ECOLI eggNOG ENOG4107NK6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107NK6 eggNOG ENOG410ZT31 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZT31 epestfind swissprot:HOKB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HOKB_ECOLI garnier swissprot:HOKB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HOKB_ECOLI helixturnhelix swissprot:HOKB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HOKB_ECOLI hmoment swissprot:HOKB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HOKB_ECOLI iep swissprot:HOKB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HOKB_ECOLI inforesidue swissprot:HOKB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HOKB_ECOLI octanol swissprot:HOKB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HOKB_ECOLI pepcoil swissprot:HOKB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HOKB_ECOLI pepdigest swissprot:HOKB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HOKB_ECOLI pepinfo swissprot:HOKB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HOKB_ECOLI pepnet swissprot:HOKB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HOKB_ECOLI pepstats swissprot:HOKB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HOKB_ECOLI pepwheel swissprot:HOKB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HOKB_ECOLI pepwindow swissprot:HOKB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HOKB_ECOLI sigcleave swissprot:HOKB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HOKB_ECOLI ## Database ID URL or Descriptions # EcoGene EG10915 rpsP # FUNCTION RS16_ECOLI In addition to being a ribosomal protein, S16 also has a cation-dependent endonuclease activity. {ECO 0000269|PubMed 8730873}. # FUNCTION RS16_ECOLI In-frame fusions with the ribosome maturation factor rimM suppress mutations in the latter (probably due to increased rimM expression) and are found in translationally active 70S ribosomes. {ECO 0000269|PubMed 8730873}. # GO_component GO:0022627 cytosolic small ribosomal subunit; IDA:EcoCyc. # GO_function GO:0003735 structural constituent of ribosome; IBA:GO_Central. # GO_function GO:0004520 endodeoxyribonuclease activity; IDA:EcoCyc. # GO_function GO:0043566 structure-specific DNA binding; IDA:EcoCyc. # GO_process GO:0000028 ribosomal small subunit assembly; IDA:EcoCyc. # GO_process GO:0006412 translation; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_function GO:0004518 nuclease activity # GOslim_process GO:0006412 translation # GOslim_process GO:0022618 ribonucleoprotein complex assembly # Gene3D 3.30.1320.10 -; 1. # HAMAP MF_00385 Ribosomal_S16 # INDUCTION RS16_ECOLI Part of the rpsP-rimM-trmD-rplS operon. # IntAct P0A7T3 55 # InterPro IPR000307 Ribosomal_S16 # InterPro IPR020592 Ribosomal_S16_CS # InterPro IPR023803 Ribosomal_S16_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=9190.5; Method=MALDI; Range=1-82; Evidence={ECO:0000269|PubMed 10094780}; # Organism RS16_ECOLI Escherichia coli (strain K12) # PANTHER PTHR12919 PTHR12919 # PATRIC 32120617 VBIEscCol129921_2707 # PDB 1M5G Model; -; P=1-82 # PDB 1ML5 EM; 14.00 A; S=1-82 # PDB 2YKR EM; 9.80 A; P=1-82 # PDB 3J9Y EM; 3.90 A; p=1-82 # PDB 3J9Z EM; 3.60 A; SP=1-82 # PDB 3JA1 EM; 3.60 A; SP=1-82 # PDB 3JBU EM; 3.64 A; P=1-82 # PDB 3JBV EM; 3.32 A; P=1-82 # PDB 3JCD EM; 3.70 A; p=1-82 # PDB 3JCE EM; 3.20 A; p=1-82 # PDB 3JCJ EM; 3.70 A; y=1-82 # PDB 3JCN EM; 4.60 A; s=1-82 # PDB 4A2I EM; 16.50 A; P=1-82 # PDB 4ADV EM; 13.50 A; P=1-82 # PDB 4U1U X-ray; 2.95 A; AP/CP=1-82 # PDB 4U1V X-ray; 3.00 A; AP/CP=1-82 # PDB 4U20 X-ray; 2.90 A; AP/CP=1-82 # PDB 4U24 X-ray; 2.90 A; AP/CP=1-82 # PDB 4U25 X-ray; 2.90 A; AP/CP=1-82 # PDB 4U26 X-ray; 2.80 A; AP/CP=1-82 # PDB 4U27 X-ray; 2.80 A; AP/CP=1-82 # PDB 4V47 EM; 12.30 A; BP=1-82 # PDB 4V48 EM; 11.50 A; BP=1-82 # PDB 4V4H X-ray; 3.46 A; AP/CP=1-82 # PDB 4V4Q X-ray; 3.46 A; AP/CP=1-82 # PDB 4V4V EM; 15.00 A; AP=1-78 # PDB 4V4W EM; 15.00 A; AP=1-78 # PDB 4V50 X-ray; 3.22 A; AP/CP=1-82 # PDB 4V52 X-ray; 3.21 A; AP/CP=1-82 # PDB 4V53 X-ray; 3.54 A; AP/CP=1-82 # PDB 4V54 X-ray; 3.30 A; AP/CP=1-82 # PDB 4V55 X-ray; 4.00 A; AP/CP=1-82 # PDB 4V56 X-ray; 3.93 A; AP/CP=1-82 # PDB 4V57 X-ray; 3.50 A; AP/CP=1-82 # PDB 4V5B X-ray; 3.74 A; BP/DP=1-82 # PDB 4V5H EM; 5.80 A; AP=1-80 # PDB 4V5Y X-ray; 4.45 A; AP/CP=1-82 # PDB 4V64 X-ray; 3.50 A; AP/CP=1-82 # PDB 4V65 EM; 9.00 A; AI=1-82 # PDB 4V66 EM; 9.00 A; AI=1-82 # PDB 4V69 EM; 6.70 A; AP=1-80 # PDB 4V6C X-ray; 3.19 A; AP/CP=1-82 # PDB 4V6D X-ray; 3.81 A; AP/CP=1-82 # PDB 4V6E X-ray; 3.71 A; AP/CP=1-82 # PDB 4V6K EM; 8.25 A; BT=1-82 # PDB 4V6L EM; 13.20 A; AT=1-82 # PDB 4V6M EM; 7.10 A; AP=1-82 # PDB 4V6N EM; 12.10 A; BS=1-82 # PDB 4V6O EM; 14.70 A; AS=1-82 # PDB 4V6P EM; 13.50 A; AS=1-82 # PDB 4V6Q EM; 11.50 A; AS=1-82 # PDB 4V6R EM; 11.50 A; AS=1-82 # PDB 4V6S EM; 13.10 A; BR=1-82 # PDB 4V6T EM; 8.30 A; AP=1-82 # PDB 4V6V EM; 9.80 A; AP=1-82 # PDB 4V6Y EM; 12.00 A; AP=1-80 # PDB 4V6Z EM; 12.00 A; AP=1-80 # PDB 4V70 EM; 17.00 A; AP=1-80 # PDB 4V71 EM; 20.00 A; AP=1-80 # PDB 4V72 EM; 13.00 A; AP=1-80 # PDB 4V73 EM; 15.00 A; AP=1-80 # PDB 4V74 EM; 17.00 A; AP=1-80 # PDB 4V75 EM; 12.00 A; AP=1-80 # PDB 4V76 EM; 17.00 A; AP=1-80 # PDB 4V77 EM; 17.00 A; AP=1-80 # PDB 4V78 EM; 20.00 A; AP=1-80 # PDB 4V79 EM; 15.00 A; AP=1-80 # PDB 4V7A EM; 9.00 A; AP=1-80 # PDB 4V7B EM; 6.80 A; AP=1-82 # PDB 4V7C EM; 7.60 A; AP=1-82 # PDB 4V7D EM; 7.60 A; BP=1-82 # PDB 4V7I EM; 9.60 A; BP=1-82 # PDB 4V7S X-ray; 3.25 A; AP=1-82, CP=1-80 # PDB 4V7T X-ray; 3.19 A; AP=1-82, CP=1-80 # PDB 4V7U X-ray; 3.10 A; AP/CP=1-82 # PDB 4V7V X-ray; 3.29 A; AP=1-82, CP=1-80 # PDB 4V85 X-ray; 3.20 A; P=1-82 # PDB 4V89 X-ray; 3.70 A; AP=1-82 # PDB 4V9C X-ray; 3.30 A; AP/CP=1-82 # PDB 4V9D X-ray; 3.00 A; AP/BP=1-82 # PDB 4V9O X-ray; 2.90 A; BP/DP/FP/HP=1-82 # PDB 4V9P X-ray; 2.90 A; BP/DP/FP/HP=1-82 # PDB 4WF1 X-ray; 3.09 A; AP/CP=1-82 # PDB 4WOI X-ray; 3.00 A; AP/DP=1-82 # PDB 4WWW X-ray; 3.10 A; QP/XP=1-82 # PDB 4YBB X-ray; 2.10 A; AP/BP=1-82 # PDB 5AFI EM; 2.90 A; p=1-82 # PDB 5IQR EM; 3.00 A; u=1-82 # PDB 5IT8 X-ray; 3.12 A; AP/BP=1-82 # PDB 5J5B X-ray; 2.80 A; AP/BP=1-82 # PDB 5J7L X-ray; 3.00 A; AP/BP=1-82 # PDB 5J88 X-ray; 3.32 A; AP/BP=1-82 # PDB 5J8A X-ray; 3.10 A; AP/BP=1-82 # PDB 5J91 X-ray; 2.96 A; AP/BP=1-82 # PDB 5JC9 X-ray; 3.03 A; AP/BP=1-82 # PDB 5JTE EM; 3.60 A; AP=1-82 # PDB 5JU8 EM; 3.60 A; AP=1-82 # PDB 5KCR EM; 3.60 A; 1p=1-82 # PDB 5KCS EM; 3.90 A; 1p=1-82 # PDB 5KPS EM; 3.90 A; 21=1-82 # PDB 5KPV EM; 4.10 A; 20=1-82 # PDB 5KPW EM; 3.90 A; 20=1-82 # PDB 5KPX EM; 3.90 A; 20=1-82 # PDB 5L3P EM; 3.70 A; p=1-82 # PIR S07948 R3EC16 # PROSITE PS00732 RIBOSOMAL_S16 # Pfam PF00886 Ribosomal_S16 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 30S ribosomal protein S16 {ECO:0000255|HAMAP-Rule MF_00385} # RefSeq NP_417100 NC_000913.3 # RefSeq WP_000256450 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein S16P family. {ECO:0000255|HAMAP-Rule MF_00385}. # SUPFAM SSF54565 SSF54565 # TIGRFAMs TIGR00002 S16 # eggNOG COG0228 LUCA # eggNOG ENOG4105K5M Bacteria BLAST swissprot:RS16_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RS16_ECOLI BioCyc ECOL316407:JW2590-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2590-MONOMER BioCyc EcoCyc:EG10915-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10915-MONOMER BioCyc MetaCyc:EG10915-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10915-MONOMER COG COG0228 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0228 DIP DIP-47829N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47829N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1016/S0092-8674(03)00427-6 http://dx.doi.org/10.1016/S0092-8674(03)00427-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb841 http://dx.doi.org/10.1038/nsb841 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1365-2958.1996.tb02476.x http://dx.doi.org/10.1111/j.1365-2958.1996.tb02476.x DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.183.18.5352-5357.2001 http://dx.doi.org/10.1128/JB.183.18.5352-5357.2001 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X01818 http://www.ebi.ac.uk/ena/data/view/X01818 EchoBASE EB0908 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0908 EcoGene EG10915 http://www.ecogene.org/geneInfo.php?eg_id=EG10915 EnsemblBacteria AAC75658 http://www.ensemblgenomes.org/id/AAC75658 EnsemblBacteria AAC75658 http://www.ensemblgenomes.org/id/AAC75658 EnsemblBacteria BAA16494 http://www.ensemblgenomes.org/id/BAA16494 EnsemblBacteria BAA16494 http://www.ensemblgenomes.org/id/BAA16494 EnsemblBacteria BAA16494 http://www.ensemblgenomes.org/id/BAA16494 EnsemblBacteria b2609 http://www.ensemblgenomes.org/id/b2609 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0022627 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022627 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_function GO:0004520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004520 GO_function GO:0043566 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043566 GO_process GO:0000028 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000028 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_process GO:0022618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022618 Gene3D 3.30.1320.10 http://www.cathdb.info/version/latest/superfamily/3.30.1320.10 GeneID 947103 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947103 HAMAP MF_00385 http://hamap.expasy.org/unirule/MF_00385 HOGENOM HOG000246720 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000246720&db=HOGENOM6 InParanoid P0A7T3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7T3 IntAct P0A7T3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7T3* InterPro IPR000307 http://www.ebi.ac.uk/interpro/entry/IPR000307 InterPro IPR020592 http://www.ebi.ac.uk/interpro/entry/IPR020592 InterPro IPR023803 http://www.ebi.ac.uk/interpro/entry/IPR023803 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW2590 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2590 KEGG_Gene eco:b2609 http://www.genome.jp/dbget-bin/www_bget?eco:b2609 KEGG_Orthology KO:K02959 http://www.genome.jp/dbget-bin/www_bget?KO:K02959 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 MINT MINT-1280042 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1280042 OMA RVEHWVG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RVEHWVG PANTHER PTHR12919 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12919 PDB 1M5G http://www.ebi.ac.uk/pdbe-srv/view/entry/1M5G PDB 1ML5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ML5 PDB 2YKR http://www.ebi.ac.uk/pdbe-srv/view/entry/2YKR PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 4A2I http://www.ebi.ac.uk/pdbe-srv/view/entry/4A2I PDB 4ADV http://www.ebi.ac.uk/pdbe-srv/view/entry/4ADV PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4V47 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V47 PDB 4V48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V48 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 1M5G http://www.ebi.ac.uk/pdbsum/1M5G PDBsum 1ML5 http://www.ebi.ac.uk/pdbsum/1ML5 PDBsum 2YKR http://www.ebi.ac.uk/pdbsum/2YKR PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 4A2I http://www.ebi.ac.uk/pdbsum/4A2I PDBsum 4ADV http://www.ebi.ac.uk/pdbsum/4ADV PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4V47 http://www.ebi.ac.uk/pdbsum/4V47 PDBsum 4V48 http://www.ebi.ac.uk/pdbsum/4V48 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PROSITE PS00732 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00732 PSORT swissprot:RS16_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RS16_ECOLI PSORT-B swissprot:RS16_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RS16_ECOLI PSORT2 swissprot:RS16_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RS16_ECOLI Pfam PF00886 http://pfam.xfam.org/family/PF00886 Phobius swissprot:RS16_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RS16_ECOLI PhylomeDB P0A7T3 http://phylomedb.org/?seqid=P0A7T3 ProteinModelPortal P0A7T3 http://www.proteinmodelportal.org/query/uniprot/P0A7T3 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 11514519 http://www.ncbi.nlm.nih.gov/pubmed/11514519 PubMed 12244297 http://www.ncbi.nlm.nih.gov/pubmed/12244297 PubMed 12809609 http://www.ncbi.nlm.nih.gov/pubmed/12809609 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 336510 http://www.ncbi.nlm.nih.gov/pubmed/336510 PubMed 6357787 http://www.ncbi.nlm.nih.gov/pubmed/6357787 PubMed 8730873 http://www.ncbi.nlm.nih.gov/pubmed/8730873 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_417100 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417100 RefSeq WP_000256450 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000256450 SMR P0A7T3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7T3 STRING 511145.b2609 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2609&targetmode=cogs STRING COG0228 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0228&targetmode=cogs SUPFAM SSF54565 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54565 TIGRFAMs TIGR00002 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00002 UniProtKB RS16_ECOLI http://www.uniprot.org/uniprot/RS16_ECOLI UniProtKB-AC P0A7T3 http://www.uniprot.org/uniprot/P0A7T3 charge swissprot:RS16_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RS16_ECOLI eggNOG COG0228 http://eggnogapi.embl.de/nog_data/html/tree/COG0228 eggNOG ENOG4105K5M http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K5M epestfind swissprot:RS16_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RS16_ECOLI garnier swissprot:RS16_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RS16_ECOLI helixturnhelix swissprot:RS16_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RS16_ECOLI hmoment swissprot:RS16_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RS16_ECOLI iep swissprot:RS16_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RS16_ECOLI inforesidue swissprot:RS16_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RS16_ECOLI octanol swissprot:RS16_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RS16_ECOLI pepcoil swissprot:RS16_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RS16_ECOLI pepdigest swissprot:RS16_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RS16_ECOLI pepinfo swissprot:RS16_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RS16_ECOLI pepnet swissprot:RS16_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RS16_ECOLI pepstats swissprot:RS16_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RS16_ECOLI pepwheel swissprot:RS16_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RS16_ECOLI pepwindow swissprot:RS16_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RS16_ECOLI sigcleave swissprot:RS16_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RS16_ECOLI ## Database ID URL or Descriptions # AltName KPYK1_ECOLI PK-1 # BioGrid 4260275 18 # CATALYTIC ACTIVITY KPYK1_ECOLI ATP + pyruvate = ADP + phosphoenolpyruvate. # COFACTOR Name=K(+); Xref=ChEBI:CHEBI 29103; # COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI 18420; # ENZYME REGULATION KPYK1_ECOLI Belongs to type I PK; fructose 1,6- bisphosphate-activated. # EcoGene EG10804 pykF # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0000287 magnesium ion binding; IEA:InterPro. # GO_function GO:0004743 pyruvate kinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016301 kinase activity; IEA:UniProtKB-KW. # GO_function GO:0030955 potassium ion binding; IEA:InterPro. # GO_function GO:0042802 identical protein binding; IPI:EcoCyc. # GO_process GO:0009408 response to heat; IMP:EcoCyc. # GO_process GO:0051289 protein homotetramerization; IPI:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0006950 response to stress # Gene3D 2.40.33.10 -; 1. # Gene3D 3.20.20.60 -; 2. # Gene3D 3.40.1380.20 -; 1. # IntAct P0AD61 21 # InterPro IPR001697 Pyr_Knase # InterPro IPR011037 Pyrv_Knase-like_insert_dom # InterPro IPR015793 Pyrv_Knase_brl # InterPro IPR015794 Pyrv_Knase_a/b # InterPro IPR015795 Pyrv_Knase_C # InterPro IPR015806 Pyrv_Knase_insert_dom # InterPro IPR015813 Pyrv/PenolPyrv_Kinase-like_dom # InterPro IPR018209 Pyrv_Knase_AS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00010 Glycolysis / Gluconeogenesis # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00620 Pyruvate metabolism # KEGG_Pathway ko00710 Carbon fixation in photosynthetic organisms # KEGG_Pathway ko04930 Type II diabetes mellitus # KEGG_Pathway ko05203 Viral carcinogenesis # Organism KPYK1_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11817 PTHR11817 # PATHWAY Carbohydrate degradation; glycolysis; pyruvate from D- glyceraldehyde 3-phosphate step 5/5. # PATRIC 32118658 VBIEscCol129921_1747 # PDB 1E0T X-ray; 1.80 A; A/B/C/D=1-470 # PDB 1E0U X-ray; 2.80 A; A/B/C/D=1-470 # PDB 1PKY X-ray; 2.50 A; A/B/C/D=1-470 # PDB 4YNG X-ray; 2.28 A; A/B/C/D/E/F/G/H=1-470 # PIR D64925 D64925 # PRINTS PR01050 PYRUVTKNASE # PROSITE PS00110 PYRUVATE_KINASE # Pfam PF00224 PK # Pfam PF02887 PK_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName KPYK1_ECOLI Pyruvate kinase I # RefSeq NP_416191 NC_000913.3 # RefSeq WP_001295403 NZ_LN832404.1 # SIMILARITY Belongs to the pyruvate kinase family. {ECO 0000305}. # SUBUNIT KPYK1_ECOLI Homotetramer. # SUPFAM SSF50800 SSF50800 # SUPFAM SSF51621 SSF51621; 2 # SUPFAM SSF52935 SSF52935 # TIGRFAMs TIGR01064 pyruv_kin # UniPathway UPA00109 UER00188 # eggNOG COG0469 LUCA # eggNOG ENOG4105CA9 Bacteria BLAST swissprot:KPYK1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:KPYK1_ECOLI BioCyc ECOL316407:JW1666-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1666-MONOMER BioCyc EcoCyc:PKI-MONOMER http://biocyc.org/getid?id=EcoCyc:PKI-MONOMER BioCyc MetaCyc:PKI-MONOMER http://biocyc.org/getid?id=MetaCyc:PKI-MONOMER COG COG0469 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0469 DIP DIP-36221N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36221N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1016/S0969-2126(01)00207-6 http://dx.doi.org/10.1016/S0969-2126(01)00207-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.86.18.6883 http://dx.doi.org/10.1073/pnas.86.18.6883 DOI 10.1074/jbc.M001870200 http://dx.doi.org/10.1074/jbc.M001870200 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.40 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.40 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M24636 http://www.ebi.ac.uk/ena/data/view/M24636 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U68703 http://www.ebi.ac.uk/ena/data/view/U68703 ENZYME 2.7.1.40 http://enzyme.expasy.org/EC/2.7.1.40 EchoBASE EB0797 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0797 EcoGene EG10804 http://www.ecogene.org/geneInfo.php?eg_id=EG10804 EnsemblBacteria AAC74746 http://www.ensemblgenomes.org/id/AAC74746 EnsemblBacteria AAC74746 http://www.ensemblgenomes.org/id/AAC74746 EnsemblBacteria BAA15445 http://www.ensemblgenomes.org/id/BAA15445 EnsemblBacteria BAA15445 http://www.ensemblgenomes.org/id/BAA15445 EnsemblBacteria BAA15445 http://www.ensemblgenomes.org/id/BAA15445 EnsemblBacteria b1676 http://www.ensemblgenomes.org/id/b1676 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0004743 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004743 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_function GO:0030955 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030955 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GO_process GO:0051289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051289 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 2.40.33.10 http://www.cathdb.info/version/latest/superfamily/2.40.33.10 Gene3D 3.20.20.60 http://www.cathdb.info/version/latest/superfamily/3.20.20.60 Gene3D 3.40.1380.20 http://www.cathdb.info/version/latest/superfamily/3.40.1380.20 GeneID 946179 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946179 HOGENOM HOG000021559 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000021559&db=HOGENOM6 InParanoid P0AD61 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AD61 IntAct P0AD61 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AD61* IntEnz 2.7.1.40 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.40 InterPro IPR001697 http://www.ebi.ac.uk/interpro/entry/IPR001697 InterPro IPR011037 http://www.ebi.ac.uk/interpro/entry/IPR011037 InterPro IPR015793 http://www.ebi.ac.uk/interpro/entry/IPR015793 InterPro IPR015794 http://www.ebi.ac.uk/interpro/entry/IPR015794 InterPro IPR015795 http://www.ebi.ac.uk/interpro/entry/IPR015795 InterPro IPR015806 http://www.ebi.ac.uk/interpro/entry/IPR015806 InterPro IPR015813 http://www.ebi.ac.uk/interpro/entry/IPR015813 InterPro IPR018209 http://www.ebi.ac.uk/interpro/entry/IPR018209 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1666 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1666 KEGG_Gene eco:b1676 http://www.genome.jp/dbget-bin/www_bget?eco:b1676 KEGG_Orthology KO:K00873 http://www.genome.jp/dbget-bin/www_bget?KO:K00873 KEGG_Pathway ko00010 http://www.genome.jp/kegg-bin/show_pathway?ko00010 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00620 http://www.genome.jp/kegg-bin/show_pathway?ko00620 KEGG_Pathway ko00710 http://www.genome.jp/kegg-bin/show_pathway?ko00710 KEGG_Pathway ko04930 http://www.genome.jp/kegg-bin/show_pathway?ko04930 KEGG_Pathway ko05203 http://www.genome.jp/kegg-bin/show_pathway?ko05203 KEGG_Reaction rn:R00200 http://www.genome.jp/dbget-bin/www_bget?rn:R00200 KEGG_Reaction rn:R00430 http://www.genome.jp/dbget-bin/www_bget?rn:R00430 KEGG_Reaction rn:R01138 http://www.genome.jp/dbget-bin/www_bget?rn:R01138 KEGG_Reaction rn:R01858 http://www.genome.jp/dbget-bin/www_bget?rn:R01858 KEGG_Reaction rn:R02320 http://www.genome.jp/dbget-bin/www_bget?rn:R02320 OMA GTHEEHK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GTHEEHK PANTHER PTHR11817 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11817 PDB 1E0T http://www.ebi.ac.uk/pdbe-srv/view/entry/1E0T PDB 1E0U http://www.ebi.ac.uk/pdbe-srv/view/entry/1E0U PDB 1PKY http://www.ebi.ac.uk/pdbe-srv/view/entry/1PKY PDB 4YNG http://www.ebi.ac.uk/pdbe-srv/view/entry/4YNG PDBsum 1E0T http://www.ebi.ac.uk/pdbsum/1E0T PDBsum 1E0U http://www.ebi.ac.uk/pdbsum/1E0U PDBsum 1PKY http://www.ebi.ac.uk/pdbsum/1PKY PDBsum 4YNG http://www.ebi.ac.uk/pdbsum/4YNG PRINTS PR01050 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01050 PROSITE PS00110 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00110 PSORT swissprot:KPYK1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:KPYK1_ECOLI PSORT-B swissprot:KPYK1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:KPYK1_ECOLI PSORT2 swissprot:KPYK1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:KPYK1_ECOLI Pfam PF00224 http://pfam.xfam.org/family/PF00224 Pfam PF02887 http://pfam.xfam.org/family/PF02887 Phobius swissprot:KPYK1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:KPYK1_ECOLI PhylomeDB P0AD61 http://phylomedb.org/?seqid=P0AD61 ProteinModelPortal P0AD61 http://www.proteinmodelportal.org/query/uniprot/P0AD61 PubMed 10751408 http://www.ncbi.nlm.nih.gov/pubmed/10751408 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1859631 http://www.ncbi.nlm.nih.gov/pubmed/1859631 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 2653362 http://www.ncbi.nlm.nih.gov/pubmed/2653362 PubMed 2674937 http://www.ncbi.nlm.nih.gov/pubmed/2674937 PubMed 8591049 http://www.ncbi.nlm.nih.gov/pubmed/8591049 PubMed 9023191 http://www.ncbi.nlm.nih.gov/pubmed/9023191 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_416191 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416191 RefSeq WP_001295403 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295403 SMR P0AD61 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AD61 STRING 511145.b1676 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1676&targetmode=cogs STRING COG0469 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0469&targetmode=cogs SUPFAM SSF50800 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50800 SUPFAM SSF51621 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51621 SUPFAM SSF52935 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52935 SWISS-2DPAGE P0AD61 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AD61 TIGRFAMs TIGR01064 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01064 UniProtKB KPYK1_ECOLI http://www.uniprot.org/uniprot/KPYK1_ECOLI UniProtKB-AC P0AD61 http://www.uniprot.org/uniprot/P0AD61 charge swissprot:KPYK1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:KPYK1_ECOLI eggNOG COG0469 http://eggnogapi.embl.de/nog_data/html/tree/COG0469 eggNOG ENOG4105CA9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CA9 epestfind swissprot:KPYK1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:KPYK1_ECOLI garnier swissprot:KPYK1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:KPYK1_ECOLI helixturnhelix swissprot:KPYK1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:KPYK1_ECOLI hmoment swissprot:KPYK1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:KPYK1_ECOLI iep swissprot:KPYK1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:KPYK1_ECOLI inforesidue swissprot:KPYK1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:KPYK1_ECOLI octanol swissprot:KPYK1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:KPYK1_ECOLI pepcoil swissprot:KPYK1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:KPYK1_ECOLI pepdigest swissprot:KPYK1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:KPYK1_ECOLI pepinfo swissprot:KPYK1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:KPYK1_ECOLI pepnet swissprot:KPYK1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:KPYK1_ECOLI pepstats swissprot:KPYK1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:KPYK1_ECOLI pepwheel swissprot:KPYK1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:KPYK1_ECOLI pepwindow swissprot:KPYK1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:KPYK1_ECOLI sigcleave swissprot:KPYK1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:KPYK1_ECOLI ## Database ID URL or Descriptions # BioGrid 4260205 15 # EcoGene EG12713 yddG # FUNCTION YDDG_ECOLI Probable efflux pump. Overexpression confers resistance to phenylalanine and increases export of phenylalanine, tyrosine and tryptophan. {ECO 0000269|PubMed 17784858}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005302 L-tyrosine transmembrane transporter activity; IMP:EcoCyc. # GO_function GO:0015192 L-phenylalanine transmembrane transporter activity; IMP:EcoCyc. # GO_function GO:0015196 L-tryptophan transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0015823 phenylalanine transport; IMP:EcoCyc. # GO_process GO:0015827 tryptophan transport; IMP:EcoCyc. # GO_process GO:0015828 tyrosine transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR000620 EamA_dom # Organism YDDG_ECOLI Escherichia coli (strain K12) # PATRIC 32118238 VBIEscCol129921_1539 # PIR D64900 D64900 # Pfam PF00892 EamA; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDDG_ECOLI Aromatic amino acid exporter YddG # RefSeq NP_415990 NC_000913.3 # SEQUENCE CAUTION Sequence=BAA15122.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the drug/metabolite transporter (DMT) superfamily. Aromatic amino acid/paraquat exporter (ArAA/P-E) (TC 2.A.7.17) family. {ECO 0000305}. # SIMILARITY Contains 2 EamA domains. {ECO 0000305}. # SUBCELLULAR LOCATION YDDG_ECOLI Cell inner membrane {ECO 0000269|PubMed 21042032}; Multi-pass membrane protein {ECO 0000269|PubMed 21042032}. # TCDB 2.A.7.17 the drug/metabolite transporter (dmt) superfamily # eggNOG COG0697 LUCA # eggNOG ENOG4105RPH Bacteria BLAST swissprot:YDDG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDDG_ECOLI BioCyc ECOL316407:JW1469-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1469-MONOMER BioCyc EcoCyc:EG12713-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12713-MONOMER BioCyc MetaCyc:EG12713-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12713-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1111/j.1574-6968.2007.00894.x http://dx.doi.org/10.1111/j.1574-6968.2007.00894.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1159/000320699 http://dx.doi.org/10.1159/000320699 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M75029 http://www.ebi.ac.uk/ena/data/view/M75029 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2574 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2574 EcoGene EG12713 http://www.ecogene.org/geneInfo.php?eg_id=EG12713 EnsemblBacteria AAD13437 http://www.ensemblgenomes.org/id/AAD13437 EnsemblBacteria AAD13437 http://www.ensemblgenomes.org/id/AAD13437 EnsemblBacteria BAA15122 http://www.ensemblgenomes.org/id/BAA15122 EnsemblBacteria BAA15122 http://www.ensemblgenomes.org/id/BAA15122 EnsemblBacteria BAA15122 http://www.ensemblgenomes.org/id/BAA15122 EnsemblBacteria b1473 http://www.ensemblgenomes.org/id/b1473 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005302 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005302 GO_function GO:0015192 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015192 GO_function GO:0015196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015196 GO_process GO:0015823 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015823 GO_process GO:0015827 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015827 GO_process GO:0015828 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015828 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 945942 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945942 HOGENOM HOG000194714 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000194714&db=HOGENOM6 InParanoid P46136 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P46136 InterPro IPR000620 http://www.ebi.ac.uk/interpro/entry/IPR000620 KEGG_Gene ecj:JW1469 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1469 KEGG_Gene eco:b1473 http://www.genome.jp/dbget-bin/www_bget?eco:b1473 OMA VALWFHY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VALWFHY PSORT swissprot:YDDG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDDG_ECOLI PSORT-B swissprot:YDDG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDDG_ECOLI PSORT2 swissprot:YDDG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDDG_ECOLI Pfam PF00892 http://pfam.xfam.org/family/PF00892 Phobius swissprot:YDDG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDDG_ECOLI PhylomeDB P46136 http://phylomedb.org/?seqid=P46136 ProteinModelPortal P46136 http://www.proteinmodelportal.org/query/uniprot/P46136 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17784858 http://www.ncbi.nlm.nih.gov/pubmed/17784858 PubMed 1834669 http://www.ncbi.nlm.nih.gov/pubmed/1834669 PubMed 21042032 http://www.ncbi.nlm.nih.gov/pubmed/21042032 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415990 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415990 STRING 511145.b1473 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1473&targetmode=cogs TCDB 2.A.7.17 http://www.tcdb.org/search/result.php?tc=2.A.7.17 UniProtKB YDDG_ECOLI http://www.uniprot.org/uniprot/YDDG_ECOLI UniProtKB-AC P46136 http://www.uniprot.org/uniprot/P46136 charge swissprot:YDDG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDDG_ECOLI eggNOG COG0697 http://eggnogapi.embl.de/nog_data/html/tree/COG0697 eggNOG ENOG4105RPH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105RPH epestfind swissprot:YDDG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDDG_ECOLI garnier swissprot:YDDG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDDG_ECOLI helixturnhelix swissprot:YDDG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDDG_ECOLI hmoment swissprot:YDDG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDDG_ECOLI iep swissprot:YDDG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDDG_ECOLI inforesidue swissprot:YDDG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDDG_ECOLI octanol swissprot:YDDG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDDG_ECOLI pepcoil swissprot:YDDG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDDG_ECOLI pepdigest swissprot:YDDG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDDG_ECOLI pepinfo swissprot:YDDG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDDG_ECOLI pepnet swissprot:YDDG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDDG_ECOLI pepstats swissprot:YDDG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDDG_ECOLI pepwheel swissprot:YDDG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDDG_ECOLI pepwindow swissprot:YDDG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDDG_ECOLI sigcleave swissprot:YDDG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDDG_ECOLI ## Database ID URL or Descriptions # BioGrid 4261107 99 # CDD cd06170 LuxR_C_like # EcoGene EG11140 uvrY # FUNCTION UVRY_ECOLI Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the effects of CsrA on csrB RNA by BarA-dependent and BarA-independent mechanisms. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0000156 phosphorelay response regulator activity; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0000160 phosphorelay signal transduction system; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004871 signal transducer activity # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # INDUCTION UVRY_ECOLI Expression is regulated by SidA. # IntAct P0AED5 37 # InterPro IPR000792 Tscrpt_reg_LuxR_C # InterPro IPR001789 Sig_transdc_resp-reg_receiver # InterPro IPR011006 CheY-like_superfamily # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR016032 Sig_transdc_resp-reg_C-effctor # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02022 M00475 BarA-UvrY (central carbon metabolism) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # Organism UVRY_ECOLI Escherichia coli (strain K12) # PATRIC 32119161 VBIEscCol129921_1995 # PIR A26750 QQEC24 # PRINTS PR00038 HTHLUXR # PROSITE PS00622 HTH_LUXR_1 # PROSITE PS50043 HTH_LUXR_2 # PROSITE PS50110 RESPONSE_REGULATORY # PTM UVRY_ECOLI Phosphorylated and activated by BarA. # Pfam PF00072 Response_reg # Pfam PF00196 GerE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UVRY_ECOLI Response regulator UvrY # RefSeq NP_416424 NC_000913.3 # RefSeq WP_000611335 NZ_LN832404.1 # SIMILARITY Contains 1 HTH luxR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00411}. # SIMILARITY Contains 1 response regulatory domain. {ECO:0000255|PROSITE-ProRule PRU00169}. # SMART SM00421 HTH_LUXR # SMART SM00448 REC # SUBCELLULAR LOCATION UVRY_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF46894 SSF46894 # SUPFAM SSF52172 SSF52172 # eggNOG COG2197 LUCA # eggNOG ENOG4105WH1 Bacteria BLAST swissprot:UVRY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UVRY_ECOLI BioCyc ECOL316407:JW1899-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1899-MONOMER BioCyc EcoCyc:EG11140-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11140-MONOMER COG COG2197 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2197 DIP DIP-35922N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35922N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M001550200 http://dx.doi.org/10.1074/jbc.M001550200 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/nar/14.5.2301 http://dx.doi.org/10.1093/nar/14.5.2301 DOI 10.1093/nar/15.10.4273 http://dx.doi.org/10.1093/nar/15.10.4273 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.18.5130-5140.2002 http://dx.doi.org/10.1128/JB.184.18.5130-5140.2002 DOI 10.1128/JB.185.3.843-853.2003 http://dx.doi.org/10.1128/JB.185.3.843-853.2003 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M24615 http://www.ebi.ac.uk/ena/data/view/M24615 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X03691 http://www.ebi.ac.uk/ena/data/view/X03691 EMBL X05398 http://www.ebi.ac.uk/ena/data/view/X05398 EchoBASE EB1130 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1130 EcoGene EG11140 http://www.ecogene.org/geneInfo.php?eg_id=EG11140 EnsemblBacteria AAC74981 http://www.ensemblgenomes.org/id/AAC74981 EnsemblBacteria AAC74981 http://www.ensemblgenomes.org/id/AAC74981 EnsemblBacteria BAA15734 http://www.ensemblgenomes.org/id/BAA15734 EnsemblBacteria BAA15734 http://www.ensemblgenomes.org/id/BAA15734 EnsemblBacteria BAA15734 http://www.ensemblgenomes.org/id/BAA15734 EnsemblBacteria b1914 http://www.ensemblgenomes.org/id/b1914 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000156 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000156 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 946424 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946424 HOGENOM HOG000034813 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000034813&db=HOGENOM6 InParanoid P0AED5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AED5 IntAct P0AED5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AED5* InterPro IPR000792 http://www.ebi.ac.uk/interpro/entry/IPR000792 InterPro IPR001789 http://www.ebi.ac.uk/interpro/entry/IPR001789 InterPro IPR011006 http://www.ebi.ac.uk/interpro/entry/IPR011006 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR016032 http://www.ebi.ac.uk/interpro/entry/IPR016032 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW1899 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1899 KEGG_Gene eco:b1914 http://www.genome.jp/dbget-bin/www_bget?eco:b1914 KEGG_Orthology KO:K07689 http://www.genome.jp/dbget-bin/www_bget?KO:K07689 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 MINT MINT-1243107 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1243107 OMA VICAIRS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VICAIRS PRINTS PR00038 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00038 PROSITE PS00622 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00622 PROSITE PS50043 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50043 PROSITE PS50110 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50110 PSORT swissprot:UVRY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UVRY_ECOLI PSORT-B swissprot:UVRY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UVRY_ECOLI PSORT2 swissprot:UVRY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UVRY_ECOLI Pfam PF00072 http://pfam.xfam.org/family/PF00072 Pfam PF00196 http://pfam.xfam.org/family/PF00196 Phobius swissprot:UVRY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UVRY_ECOLI PhylomeDB P0AED5 http://phylomedb.org/?seqid=P0AED5 ProteinModelPortal P0AED5 http://www.proteinmodelportal.org/query/uniprot/P0AED5 PubMed 11022030 http://www.ncbi.nlm.nih.gov/pubmed/11022030 PubMed 12193630 http://www.ncbi.nlm.nih.gov/pubmed/12193630 PubMed 12533459 http://www.ncbi.nlm.nih.gov/pubmed/12533459 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3295776 http://www.ncbi.nlm.nih.gov/pubmed/3295776 PubMed 3515318 http://www.ncbi.nlm.nih.gov/pubmed/3515318 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416424 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416424 RefSeq WP_000611335 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000611335 SMART SM00421 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00421 SMART SM00448 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00448 SMR P0AED5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AED5 STRING 511145.b1914 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1914&targetmode=cogs STRING COG2197 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2197&targetmode=cogs SUPFAM SSF46894 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46894 SUPFAM SSF52172 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52172 UniProtKB UVRY_ECOLI http://www.uniprot.org/uniprot/UVRY_ECOLI UniProtKB-AC P0AED5 http://www.uniprot.org/uniprot/P0AED5 charge swissprot:UVRY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UVRY_ECOLI eggNOG COG2197 http://eggnogapi.embl.de/nog_data/html/tree/COG2197 eggNOG ENOG4105WH1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105WH1 epestfind swissprot:UVRY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UVRY_ECOLI garnier swissprot:UVRY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UVRY_ECOLI helixturnhelix swissprot:UVRY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UVRY_ECOLI hmoment swissprot:UVRY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UVRY_ECOLI iep swissprot:UVRY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UVRY_ECOLI inforesidue swissprot:UVRY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UVRY_ECOLI octanol swissprot:UVRY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UVRY_ECOLI pepcoil swissprot:UVRY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UVRY_ECOLI pepdigest swissprot:UVRY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UVRY_ECOLI pepinfo swissprot:UVRY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UVRY_ECOLI pepnet swissprot:UVRY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UVRY_ECOLI pepstats swissprot:UVRY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UVRY_ECOLI pepwheel swissprot:UVRY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UVRY_ECOLI pepwindow swissprot:UVRY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UVRY_ECOLI sigcleave swissprot:UVRY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UVRY_ECOLI ## Database ID URL or Descriptions # BioGrid 4260900 172 # CDD cd03020 DsbA_DsbC_DsbG # DISRUPTION PHENOTYPE No visible phenotype. {ECO:0000269|PubMed 19965429}. # EcoGene EG13535 dsbG # FUNCTION DSBG_ECOLI Involved in disulfide bond formation. DsbG and DsbC are part of a periplasmic reducing system that controls the level of cysteine sulfenylation, and provides reducing equivalents to rescue oxidatively damaged secreted proteins such as ErfK, YbiS and YnhG. Probably also functions as a disulfide isomerase with a narrower substrate specificity than DsbC. DsbG is maintained in a reduced state by DsbD. Displays chaperone activity in both redox states in vitro. {ECO 0000269|PubMed 19965429}. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_function GO:0003756 protein disulfide isomerase activity; IMP:EcoliWiki. # GO_function GO:0015035 protein disulfide oxidoreductase activity; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0016853 isomerase activity # Gene3D 3.40.30.10 -; 1. # IntAct P77202 11 # InterPro IPR012336 Thioredoxin-like_fold # InterPro IPR018950 DiS-bond_isomerase_DsbC/G_N # InterPro IPR033954 DiS-bond_Isoase_DsbC/G # KEGG_Brite ko03110 Chaperones and folding catalysts # Organism DSBG_ECOLI Escherichia coli (strain K12) # PATRIC 32116386 VBIEscCol129921_0633 # PDB 1V57 X-ray; 2.00 A; A/B=18-248 # PDB 1V58 X-ray; 1.70 A; A/B=18-248 # PDB 2H0G X-ray; 2.30 A; A/B=18-248 # PDB 2H0H X-ray; 1.80 A; A/B=18-248 # PDB 2H0I X-ray; 2.40 A; A/B=18-248 # PDB 2IY2 X-ray; 1.90 A; A/B=19-89 # PDB 5G1K X-ray; 1.96 A; A/B=1-248 # PDB 5G1L X-ray; 1.70 A; A/B=1-248 # PIR B64794 B64794 # Pfam PF13098 Thioredoxin_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Thiol disulfide interchange protein DsbG # RefSeq NP_415137 NC_000913.3 # RefSeq WP_000913829 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40805.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the thioredoxin family. DsbC subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION DSBG_ECOLI Periplasm. # SUBUNIT DSBG_ECOLI Homodimer. Interacts with ErfK, YbiS and YnhG. {ECO 0000269|PubMed 17372350, ECO 0000269|PubMed 19965429}. # SUPFAM SSF52833 SSF52833 # SUPFAM SSF54423 SSF54423 # eggNOG COG1651 LUCA # eggNOG ENOG4108KHN Bacteria BLAST swissprot:DSBG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DSBG_ECOLI BioCyc ECOL316407:JW0597-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0597-MONOMER BioCyc EcoCyc:DSBG-MONOMER http://biocyc.org/getid?id=EcoCyc:DSBG-MONOMER BioCyc MetaCyc:DSBG-MONOMER http://biocyc.org/getid?id=MetaCyc:DSBG-MONOMER COG COG1651 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1651 DIP DIP-9478N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9478N DOI 10.1016/S0014-5793(98)00539-0 http://dx.doi.org/10.1016/S0014-5793(98)00539-0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1997.5581925.x http://dx.doi.org/10.1046/j.1365-2958.1997.5581925.x DOI 10.1073/pnas.0402769101 http://dx.doi.org/10.1073/pnas.0402769101 DOI 10.1074/jbc.274.12.7784 http://dx.doi.org/10.1074/jbc.274.12.7784 DOI 10.1074/jbc.275.18.13349 http://dx.doi.org/10.1074/jbc.275.18.13349 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1107/S0907444907003320 http://dx.doi.org/10.1107/S0907444907003320 DOI 10.1126/science.1179557 http://dx.doi.org/10.1126/science.1179557 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AF000956 http://www.ebi.ac.uk/ena/data/view/AF000956 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB3306 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3306 EcoGene EG13535 http://www.ecogene.org/geneInfo.php?eg_id=EG13535 EnsemblBacteria AAC73705 http://www.ensemblgenomes.org/id/AAC73705 EnsemblBacteria AAC73705 http://www.ensemblgenomes.org/id/AAC73705 EnsemblBacteria BAA35234 http://www.ensemblgenomes.org/id/BAA35234 EnsemblBacteria BAA35234 http://www.ensemblgenomes.org/id/BAA35234 EnsemblBacteria BAA35234 http://www.ensemblgenomes.org/id/BAA35234 EnsemblBacteria b0604 http://www.ensemblgenomes.org/id/b0604 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0003756 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003756 GO_function GO:0015035 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015035 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 Gene3D 3.40.30.10 http://www.cathdb.info/version/latest/superfamily/3.40.30.10 GeneID 945224 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945224 HOGENOM HOG000117889 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117889&db=HOGENOM6 InParanoid P77202 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77202 IntAct P77202 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77202* InterPro IPR012336 http://www.ebi.ac.uk/interpro/entry/IPR012336 InterPro IPR018950 http://www.ebi.ac.uk/interpro/entry/IPR018950 InterPro IPR033954 http://www.ebi.ac.uk/interpro/entry/IPR033954 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW0597 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0597 KEGG_Gene eco:b0604 http://www.genome.jp/dbget-bin/www_bget?eco:b0604 KEGG_Orthology KO:K03805 http://www.genome.jp/dbget-bin/www_bget?KO:K03805 MINT MINT-1232069 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1232069 OMA KLVYAPM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KLVYAPM PDB 1V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/1V57 PDB 1V58 http://www.ebi.ac.uk/pdbe-srv/view/entry/1V58 PDB 2H0G http://www.ebi.ac.uk/pdbe-srv/view/entry/2H0G PDB 2H0H http://www.ebi.ac.uk/pdbe-srv/view/entry/2H0H PDB 2H0I http://www.ebi.ac.uk/pdbe-srv/view/entry/2H0I PDB 2IY2 http://www.ebi.ac.uk/pdbe-srv/view/entry/2IY2 PDB 5G1K http://www.ebi.ac.uk/pdbe-srv/view/entry/5G1K PDB 5G1L http://www.ebi.ac.uk/pdbe-srv/view/entry/5G1L PDBsum 1V57 http://www.ebi.ac.uk/pdbsum/1V57 PDBsum 1V58 http://www.ebi.ac.uk/pdbsum/1V58 PDBsum 2H0G http://www.ebi.ac.uk/pdbsum/2H0G PDBsum 2H0H http://www.ebi.ac.uk/pdbsum/2H0H PDBsum 2H0I http://www.ebi.ac.uk/pdbsum/2H0I PDBsum 2IY2 http://www.ebi.ac.uk/pdbsum/2IY2 PDBsum 5G1K http://www.ebi.ac.uk/pdbsum/5G1K PDBsum 5G1L http://www.ebi.ac.uk/pdbsum/5G1L PSORT swissprot:DSBG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DSBG_ECOLI PSORT-B swissprot:DSBG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DSBG_ECOLI PSORT2 swissprot:DSBG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DSBG_ECOLI Pfam PF13098 http://pfam.xfam.org/family/PF13098 Phobius swissprot:DSBG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DSBG_ECOLI PhylomeDB P77202 http://phylomedb.org/?seqid=P77202 ProteinModelPortal P77202 http://www.proteinmodelportal.org/query/uniprot/P77202 PubMed 10075670 http://www.ncbi.nlm.nih.gov/pubmed/10075670 PubMed 10788443 http://www.ncbi.nlm.nih.gov/pubmed/10788443 PubMed 15184683 http://www.ncbi.nlm.nih.gov/pubmed/15184683 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17372350 http://www.ncbi.nlm.nih.gov/pubmed/17372350 PubMed 19965429 http://www.ncbi.nlm.nih.gov/pubmed/19965429 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9383195 http://www.ncbi.nlm.nih.gov/pubmed/9383195 PubMed 9654144 http://www.ncbi.nlm.nih.gov/pubmed/9654144 RefSeq NP_415137 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415137 RefSeq WP_000913829 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000913829 SMR P77202 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77202 STRING 511145.b0604 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0604&targetmode=cogs STRING COG1651 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1651&targetmode=cogs SUPFAM SSF52833 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52833 SUPFAM SSF54423 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54423 UniProtKB DSBG_ECOLI http://www.uniprot.org/uniprot/DSBG_ECOLI UniProtKB-AC P77202 http://www.uniprot.org/uniprot/P77202 charge swissprot:DSBG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DSBG_ECOLI eggNOG COG1651 http://eggnogapi.embl.de/nog_data/html/tree/COG1651 eggNOG ENOG4108KHN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108KHN epestfind swissprot:DSBG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DSBG_ECOLI garnier swissprot:DSBG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DSBG_ECOLI helixturnhelix swissprot:DSBG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DSBG_ECOLI hmoment swissprot:DSBG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DSBG_ECOLI iep swissprot:DSBG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DSBG_ECOLI inforesidue swissprot:DSBG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DSBG_ECOLI octanol swissprot:DSBG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DSBG_ECOLI pepcoil swissprot:DSBG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DSBG_ECOLI pepdigest swissprot:DSBG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DSBG_ECOLI pepinfo swissprot:DSBG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DSBG_ECOLI pepnet swissprot:DSBG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DSBG_ECOLI pepstats swissprot:DSBG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DSBG_ECOLI pepwheel swissprot:DSBG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DSBG_ECOLI pepwindow swissprot:DSBG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DSBG_ECOLI sigcleave swissprot:DSBG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DSBG_ECOLI ## Database ID URL or Descriptions # BioGrid 4261279 16 # EcoGene EG13194 yfjH # Organism YFJH_ECOLI Escherichia coli (strain K12) # PATRIC 32120643 VBIEscCol129921_2720 # PIR A65041 A65041 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFJH_ECOLI Uncharacterized protein YfjH # RefSeq NP_417112 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA79792.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # eggNOG ENOG4106QCB Bacteria # eggNOG ENOG410YGKB LUCA BLAST swissprot:YFJH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFJH_ECOLI BioCyc ECOL316407:JW2603-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2603-MONOMER BioCyc EcoCyc:G7359-MONOMER http://biocyc.org/getid?id=EcoCyc:G7359-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36840 http://www.ebi.ac.uk/ena/data/view/U36840 EchoBASE EB2986 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2986 EcoGene EG13194 http://www.ecogene.org/geneInfo.php?eg_id=EG13194 EnsemblBacteria AAC75671 http://www.ensemblgenomes.org/id/AAC75671 EnsemblBacteria AAC75671 http://www.ensemblgenomes.org/id/AAC75671 EnsemblBacteria BAE76758 http://www.ensemblgenomes.org/id/BAE76758 EnsemblBacteria BAE76758 http://www.ensemblgenomes.org/id/BAE76758 EnsemblBacteria BAE76758 http://www.ensemblgenomes.org/id/BAE76758 EnsemblBacteria b2623 http://www.ensemblgenomes.org/id/b2623 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946123 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946123 HOGENOM HOG000054864 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000054864&db=HOGENOM6 KEGG_Gene ecj:JW2603 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2603 KEGG_Gene eco:b2623 http://www.genome.jp/dbget-bin/www_bget?eco:b2623 OMA HRYNDSH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HRYNDSH PSORT swissprot:YFJH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFJH_ECOLI PSORT-B swissprot:YFJH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFJH_ECOLI PSORT2 swissprot:YFJH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFJH_ECOLI Phobius swissprot:YFJH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFJH_ECOLI ProteinModelPortal P52123 http://www.proteinmodelportal.org/query/uniprot/P52123 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417112 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417112 STRING 511145.b2623 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2623&targetmode=cogs UniProtKB YFJH_ECOLI http://www.uniprot.org/uniprot/YFJH_ECOLI UniProtKB-AC P52123 http://www.uniprot.org/uniprot/P52123 charge swissprot:YFJH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFJH_ECOLI eggNOG ENOG4106QCB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106QCB eggNOG ENOG410YGKB http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YGKB epestfind swissprot:YFJH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFJH_ECOLI garnier swissprot:YFJH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFJH_ECOLI helixturnhelix swissprot:YFJH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFJH_ECOLI hmoment swissprot:YFJH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFJH_ECOLI iep swissprot:YFJH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFJH_ECOLI inforesidue swissprot:YFJH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFJH_ECOLI octanol swissprot:YFJH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFJH_ECOLI pepcoil swissprot:YFJH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFJH_ECOLI pepdigest swissprot:YFJH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFJH_ECOLI pepinfo swissprot:YFJH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFJH_ECOLI pepnet swissprot:YFJH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFJH_ECOLI pepstats swissprot:YFJH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFJH_ECOLI pepwheel swissprot:YFJH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFJH_ECOLI pepwindow swissprot:YFJH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFJH_ECOLI sigcleave swissprot:YFJH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFJH_ECOLI ## Database ID URL or Descriptions # BioGrid 4261992 331 # EcoGene EG12781 yraP # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GOslim_component GO:0005575 cellular_component # InterPro IPR007055 BON_dom # InterPro IPR014004 Transpt-assoc_nodulatn_dom_bac # Organism YRAP_ECOLI Escherichia coli (strain K12) # PATRIC 32121718 VBIEscCol129921_3245 # PIR B65105 B65105 # PROSITE PS50914 BON; 2 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF04972 BON; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YRAP_ECOLI Uncharacterized protein YraP # RefSeq NP_417619 NC_000913.3 # RefSeq WP_000646033 NZ_CP014272.1 # SIMILARITY Contains 2 BON domains. {ECO:0000255|PROSITE- ProRule PRU00229}. # SMART SM00749 BON; 2 # SUBCELLULAR LOCATION YRAP_ECOLI Periplasm {ECO 0000305}. # eggNOG COG2823 LUCA # eggNOG ENOG4105W4M Bacteria BLAST swissprot:YRAP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YRAP_ECOLI BioCyc ECOL316407:JW3119-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3119-MONOMER BioCyc EcoCyc:G7644-MONOMER http://biocyc.org/getid?id=EcoCyc:G7644-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2634 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2634 EcoGene EG12781 http://www.ecogene.org/geneInfo.php?eg_id=EG12781 EnsemblBacteria AAC76184 http://www.ensemblgenomes.org/id/AAC76184 EnsemblBacteria AAC76184 http://www.ensemblgenomes.org/id/AAC76184 EnsemblBacteria BAE77196 http://www.ensemblgenomes.org/id/BAE77196 EnsemblBacteria BAE77196 http://www.ensemblgenomes.org/id/BAE77196 EnsemblBacteria BAE77196 http://www.ensemblgenomes.org/id/BAE77196 EnsemblBacteria b3150 http://www.ensemblgenomes.org/id/b3150 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GeneID 947659 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947659 HOGENOM HOG000254779 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000254779&db=HOGENOM6 InParanoid P64596 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P64596 IntAct P64596 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P64596* InterPro IPR007055 http://www.ebi.ac.uk/interpro/entry/IPR007055 InterPro IPR014004 http://www.ebi.ac.uk/interpro/entry/IPR014004 KEGG_Gene ecj:JW3119 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3119 KEGG_Gene eco:b3150 http://www.genome.jp/dbget-bin/www_bget?eco:b3150 OMA MLQGCIG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MLQGCIG PROSITE PS50914 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50914 PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YRAP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YRAP_ECOLI PSORT-B swissprot:YRAP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YRAP_ECOLI PSORT2 swissprot:YRAP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YRAP_ECOLI Pfam PF04972 http://pfam.xfam.org/family/PF04972 Phobius swissprot:YRAP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YRAP_ECOLI PhylomeDB P64596 http://phylomedb.org/?seqid=P64596 ProteinModelPortal P64596 http://www.proteinmodelportal.org/query/uniprot/P64596 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417619 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417619 RefSeq WP_000646033 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000646033 SMART SM00749 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00749 SMR P64596 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P64596 STRING 511145.b3150 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3150&targetmode=cogs UniProtKB YRAP_ECOLI http://www.uniprot.org/uniprot/YRAP_ECOLI UniProtKB-AC P64596 http://www.uniprot.org/uniprot/P64596 charge swissprot:YRAP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YRAP_ECOLI eggNOG COG2823 http://eggnogapi.embl.de/nog_data/html/tree/COG2823 eggNOG ENOG4105W4M http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105W4M epestfind swissprot:YRAP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YRAP_ECOLI garnier swissprot:YRAP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YRAP_ECOLI helixturnhelix swissprot:YRAP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YRAP_ECOLI hmoment swissprot:YRAP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YRAP_ECOLI iep swissprot:YRAP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YRAP_ECOLI inforesidue swissprot:YRAP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YRAP_ECOLI octanol swissprot:YRAP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YRAP_ECOLI pepcoil swissprot:YRAP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YRAP_ECOLI pepdigest swissprot:YRAP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YRAP_ECOLI pepinfo swissprot:YRAP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YRAP_ECOLI pepnet swissprot:YRAP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YRAP_ECOLI pepstats swissprot:YRAP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YRAP_ECOLI pepwheel swissprot:YRAP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YRAP_ECOLI pepwindow swissprot:YRAP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YRAP_ECOLI sigcleave swissprot:YRAP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YRAP_ECOLI ## Database ID URL or Descriptions # AltName SFMA_ECOLI Type-1A pilin # BioGrid 4259878 15 # DISRUPTION PHENOTYPE Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain. {ECO:0000269|PubMed 20345943}. # EcoGene EG13881 sfmA # FUNCTION SFMA_ECOLI Part of the sfmACDHF fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes. {ECO 0000269|PubMed 20345943}. # GO_component GO:0009289 pilus; IEA:UniProtKB-SubCell. # GO_process GO:0007155 cell adhesion; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0007155 cell adhesion # Gene3D 2.60.40.1090 -; 1. # INDUCTION Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression. {ECO:0000269|PubMed 20345943}. # IntAct P0ABW5 13 # InterPro IPR000259 Adhesion_dom_fimbrial # InterPro IPR008966 Adhesion_dom # KEGG_Brite ko02035 Bacterial motility proteins # MISCELLANEOUS The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed. {ECO:0000305|PubMed 20345943}. # Organism SFMA_ECOLI Escherichia coli (strain K12) # PATRIC 32116220 VBIEscCol129921_0551 # PIR A64785 A64785 # Pfam PF00419 Fimbrial # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SFMA_ECOLI Uncharacterized fimbrial-like protein SfmA # RefSeq NP_415063 NC_000913.3 # RefSeq WP_000776555 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40283.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the fimbrial protein family. {ECO 0000305}. # SUBCELLULAR LOCATION SFMA_ECOLI Fimbrium {ECO 0000250}. # SUPFAM SSF49401 SSF49401 # eggNOG ENOG4108WDE Bacteria # eggNOG ENOG4111P69 LUCA BLAST swissprot:SFMA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SFMA_ECOLI BioCyc ECOL316407:JW0519-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0519-MONOMER BioCyc EcoCyc:G6290-MONOMER http://biocyc.org/getid?id=EcoCyc:G6290-MONOMER COG COG3539 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3539 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1462-2920.2010.02202.x http://dx.doi.org/10.1111/j.1462-2920.2010.02202.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EchoBASE EB3640 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3640 EcoGene EG13881 http://www.ecogene.org/geneInfo.php?eg_id=EG13881 EnsemblBacteria AAC73632 http://www.ensemblgenomes.org/id/AAC73632 EnsemblBacteria AAC73632 http://www.ensemblgenomes.org/id/AAC73632 EnsemblBacteria BAE76307 http://www.ensemblgenomes.org/id/BAE76307 EnsemblBacteria BAE76307 http://www.ensemblgenomes.org/id/BAE76307 EnsemblBacteria BAE76307 http://www.ensemblgenomes.org/id/BAE76307 EnsemblBacteria b0530 http://www.ensemblgenomes.org/id/b0530 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009289 GO_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 Gene3D 2.60.40.1090 http://www.cathdb.info/version/latest/superfamily/2.60.40.1090 GeneID 945522 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945522 HOGENOM HOG000260127 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260127&db=HOGENOM6 InParanoid P0ABW5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABW5 IntAct P0ABW5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABW5* InterPro IPR000259 http://www.ebi.ac.uk/interpro/entry/IPR000259 InterPro IPR008966 http://www.ebi.ac.uk/interpro/entry/IPR008966 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW0519 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0519 KEGG_Gene eco:b0530 http://www.genome.jp/dbget-bin/www_bget?eco:b0530 KEGG_Orthology KO:K07352 http://www.genome.jp/dbget-bin/www_bget?KO:K07352 OMA ATFVMKY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ATFVMKY PSORT swissprot:SFMA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SFMA_ECOLI PSORT-B swissprot:SFMA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SFMA_ECOLI PSORT2 swissprot:SFMA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SFMA_ECOLI Pfam PF00419 http://pfam.xfam.org/family/PF00419 Phobius swissprot:SFMA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SFMA_ECOLI PhylomeDB P0ABW5 http://phylomedb.org/?seqid=P0ABW5 ProteinModelPortal P0ABW5 http://www.proteinmodelportal.org/query/uniprot/P0ABW5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20345943 http://www.ncbi.nlm.nih.gov/pubmed/20345943 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415063 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415063 RefSeq WP_000776555 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000776555 SMR P0ABW5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABW5 STRING 511145.b0530 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0530&targetmode=cogs STRING COG3539 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3539&targetmode=cogs SUPFAM SSF49401 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49401 UniProtKB SFMA_ECOLI http://www.uniprot.org/uniprot/SFMA_ECOLI UniProtKB-AC P0ABW5 http://www.uniprot.org/uniprot/P0ABW5 charge swissprot:SFMA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SFMA_ECOLI eggNOG ENOG4108WDE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108WDE eggNOG ENOG4111P69 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111P69 epestfind swissprot:SFMA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SFMA_ECOLI garnier swissprot:SFMA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SFMA_ECOLI helixturnhelix swissprot:SFMA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SFMA_ECOLI hmoment swissprot:SFMA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SFMA_ECOLI iep swissprot:SFMA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SFMA_ECOLI inforesidue swissprot:SFMA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SFMA_ECOLI octanol swissprot:SFMA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SFMA_ECOLI pepcoil swissprot:SFMA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SFMA_ECOLI pepdigest swissprot:SFMA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SFMA_ECOLI pepinfo swissprot:SFMA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SFMA_ECOLI pepnet swissprot:SFMA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SFMA_ECOLI pepstats swissprot:SFMA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SFMA_ECOLI pepwheel swissprot:SFMA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SFMA_ECOLI pepwindow swissprot:SFMA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SFMA_ECOLI sigcleave swissprot:SFMA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SFMA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262549 9 # CAUTION Was originally proposed to be a subunit from an L- xylulose uptake system, but PubMed:16385129 shows that it does not bind L- or D-xylulose. {ECO 0000305|PubMed:14668138}. # EcoGene EG12282 yiaN # FUNCTION YIAN_ECOLI Part of the tripartite ATP-independent periplasmic (TRAP) transport system YiaMNO involved in the uptake of 2,3- diketo-L-gulonate. {ECO 0000269|PubMed 16385129}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0022891 substrate-specific transmembrane transporter activity; IDA:EcoCyc. # GO_process GO:0034219 carbohydrate transmembrane transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0055085 transmembrane transport # InterPro IPR004681 TRAP_transpt_permease # InterPro IPR010656 DctM # Organism YIAN_ECOLI Escherichia coli (strain K12) # PATRIC 32122632 VBIEscCol129921_3693 # PIR S47799 S47799 # PIRSF PIRSF006066 HI0050 # Pfam PF06808 DctM # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIAN_ECOLI 2,3-diketo-L-gulonate TRAP transporter large permease protein YiaN # RefSeq WP_000279599 NZ_LN832404.1 # RefSeq YP_026232 NC_000913.3 # SEQUENCE CAUTION Sequence=AAB18555.1; Type=Frameshift; Positions=391; Evidence={ECO 0000305}; # SIMILARITY Belongs to the TRAP transporter large permease family. {ECO 0000305}. # SUBCELLULAR LOCATION YIAN_ECOLI Cell inner membrane {ECO 0000305}; Multi- pass membrane protein {ECO 0000305}. # SUBUNIT YIAN_ECOLI The complex comprises the extracytoplasmic solute receptor protein YiaO, and the two transmembrane proteins YiaM and YiaN. # TCDB 2.A.56.1 the tripartite atp-independent periplasmic transporter (trap-t) family # TIGRFAMs TIGR00786 dctM # eggNOG COG1593 LUCA # eggNOG ENOG4105CG6 Bacteria BLAST swissprot:YIAN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIAN_ECOLI BioCyc ECOL316407:JW5651-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5651-MONOMER BioCyc EcoCyc:EG12282-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12282-MONOMER BioCyc MetaCyc:EG12282-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12282-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1080/09687680310001607369 http://dx.doi.org/10.1080/09687680310001607369 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1099/mic.0.27851-0 http://dx.doi.org/10.1099/mic.0.27851-0 DOI 10.1099/mic.0.28334-0 http://dx.doi.org/10.1099/mic.0.28334-0 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2190 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2190 EcoGene EG12282 http://www.ecogene.org/geneInfo.php?eg_id=EG12282 EnsemblBacteria AAT48194 http://www.ensemblgenomes.org/id/AAT48194 EnsemblBacteria AAT48194 http://www.ensemblgenomes.org/id/AAT48194 EnsemblBacteria BAE77715 http://www.ensemblgenomes.org/id/BAE77715 EnsemblBacteria BAE77715 http://www.ensemblgenomes.org/id/BAE77715 EnsemblBacteria BAE77715 http://www.ensemblgenomes.org/id/BAE77715 EnsemblBacteria b3578 http://www.ensemblgenomes.org/id/b3578 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0022891 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022891 GO_process GO:0034219 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034219 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 948092 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948092 HOGENOM HOG000266922 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000266922&db=HOGENOM6 InParanoid P37675 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37675 InterPro IPR004681 http://www.ebi.ac.uk/interpro/entry/IPR004681 InterPro IPR010656 http://www.ebi.ac.uk/interpro/entry/IPR010656 KEGG_Gene ecj:JW5651 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5651 KEGG_Gene eco:b3578 http://www.genome.jp/dbget-bin/www_bget?eco:b3578 OMA IHRELNC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IHRELNC PSORT swissprot:YIAN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIAN_ECOLI PSORT-B swissprot:YIAN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIAN_ECOLI PSORT2 swissprot:YIAN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIAN_ECOLI Pfam PF06808 http://pfam.xfam.org/family/PF06808 Phobius swissprot:YIAN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIAN_ECOLI PhylomeDB P37675 http://phylomedb.org/?seqid=P37675 ProteinModelPortal P37675 http://www.proteinmodelportal.org/query/uniprot/P37675 PubMed 14668138 http://www.ncbi.nlm.nih.gov/pubmed/14668138 PubMed 15870475 http://www.ncbi.nlm.nih.gov/pubmed/15870475 PubMed 16385129 http://www.ncbi.nlm.nih.gov/pubmed/16385129 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000279599 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000279599 RefSeq YP_026232 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026232 STRING 511145.b3578 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3578&targetmode=cogs TCDB 2.A.56.1 http://www.tcdb.org/search/result.php?tc=2.A.56.1 TIGRFAMs TIGR00786 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00786 UniProtKB YIAN_ECOLI http://www.uniprot.org/uniprot/YIAN_ECOLI UniProtKB-AC P37675 http://www.uniprot.org/uniprot/P37675 charge swissprot:YIAN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIAN_ECOLI eggNOG COG1593 http://eggnogapi.embl.de/nog_data/html/tree/COG1593 eggNOG ENOG4105CG6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CG6 epestfind swissprot:YIAN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIAN_ECOLI garnier swissprot:YIAN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIAN_ECOLI helixturnhelix swissprot:YIAN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIAN_ECOLI hmoment swissprot:YIAN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIAN_ECOLI iep swissprot:YIAN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIAN_ECOLI inforesidue swissprot:YIAN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIAN_ECOLI octanol swissprot:YIAN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIAN_ECOLI pepcoil swissprot:YIAN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIAN_ECOLI pepdigest swissprot:YIAN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIAN_ECOLI pepinfo swissprot:YIAN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIAN_ECOLI pepnet swissprot:YIAN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIAN_ECOLI pepstats swissprot:YIAN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIAN_ECOLI pepwheel swissprot:YIAN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIAN_ECOLI pepwindow swissprot:YIAN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIAN_ECOLI sigcleave swissprot:YIAN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIAN_ECOLI ## Database ID URL or Descriptions # BioGrid 4260219 9 # CATALYTIC ACTIVITY TAM_ECOLI S-adenosyl-L-methionine + trans-aconitate = S- adenosyl-L-homocysteine + (E)-3-(methoxycarbonyl)pent-2-enedioate. # EcoGene EG13812 tam # FUNCTION TAM_ECOLI Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate at high affinity and of cis- aconitate, isocitrate, and citrate at lower velocities and affinities. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0030798 trans-aconitate 2-methyltransferase activity; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0008168 methyltransferase activity # Gene3D 1.10.150.290 -; 1. # Gene3D 3.40.50.150 -; 1. # HAMAP MF_00560 Tran_acon_Me_trans # InterPro IPR023149 Trans_acon_MeTrfase_C # InterPro IPR023506 Trans-aconitate_MeTrfase # InterPro IPR029063 SAM-dependent_MTases # KEGG_Brite ko01000 Enzymes # Organism TAM_ECOLI Escherichia coli (strain K12) # PATRIC 32118334 VBIEscCol129921_1587 # PIR B64906 B64906 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TAM_ECOLI Trans-aconitate 2-methyltransferase # RefSeq NP_416036 NC_000913.3 # RefSeq WP_001286597 NZ_LN832404.1 # SIMILARITY Belongs to the methyltransferase superfamily. Tam family. {ECO 0000305}. # SUBCELLULAR LOCATION TAM_ECOLI Cytoplasm. # SUBUNIT TAM_ECOLI Monomer. # SUPFAM SSF53335 SSF53335 # eggNOG COG4106 LUCA # eggNOG ENOG4107R6G Bacteria BLAST swissprot:TAM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TAM_ECOLI BioCyc ECOL316407:JW1512-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1512-MONOMER BioCyc EcoCyc:G6806-MONOMER http://biocyc.org/getid?id=EcoCyc:G6806-MONOMER BioCyc MetaCyc:G6806-MONOMER http://biocyc.org/getid?id=MetaCyc:G6806-MONOMER COG COG0500 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0500 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.274.19.13470 http://dx.doi.org/10.1074/jbc.274.19.13470 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.1.144 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.144 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.1.1.144 http://enzyme.expasy.org/EC/2.1.1.144 EchoBASE EB3573 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3573 EcoGene EG13812 http://www.ecogene.org/geneInfo.php?eg_id=EG13812 EnsemblBacteria AAC74592 http://www.ensemblgenomes.org/id/AAC74592 EnsemblBacteria AAC74592 http://www.ensemblgenomes.org/id/AAC74592 EnsemblBacteria BAE76459 http://www.ensemblgenomes.org/id/BAE76459 EnsemblBacteria BAE76459 http://www.ensemblgenomes.org/id/BAE76459 EnsemblBacteria BAE76459 http://www.ensemblgenomes.org/id/BAE76459 EnsemblBacteria b1519 http://www.ensemblgenomes.org/id/b1519 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0030798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030798 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 Gene3D 1.10.150.290 http://www.cathdb.info/version/latest/superfamily/1.10.150.290 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 GeneID 946074 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946074 HAMAP MF_00560 http://hamap.expasy.org/unirule/MF_00560 HOGENOM HOG000125295 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125295&db=HOGENOM6 InParanoid P76145 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76145 IntAct P76145 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76145* IntEnz 2.1.1.144 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.144 InterPro IPR023149 http://www.ebi.ac.uk/interpro/entry/IPR023149 InterPro IPR023506 http://www.ebi.ac.uk/interpro/entry/IPR023506 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1512 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1512 KEGG_Gene eco:b1519 http://www.genome.jp/dbget-bin/www_bget?eco:b1519 KEGG_Orthology KO:K00598 http://www.genome.jp/dbget-bin/www_bget?KO:K00598 OMA ETTYLHV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ETTYLHV PSORT swissprot:TAM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TAM_ECOLI PSORT-B swissprot:TAM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TAM_ECOLI PSORT2 swissprot:TAM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TAM_ECOLI Phobius swissprot:TAM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TAM_ECOLI PhylomeDB P76145 http://phylomedb.org/?seqid=P76145 ProteinModelPortal P76145 http://www.proteinmodelportal.org/query/uniprot/P76145 PubMed 10224113 http://www.ncbi.nlm.nih.gov/pubmed/10224113 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416036 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416036 RefSeq WP_001286597 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001286597 SMR P76145 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76145 STRING 511145.b1519 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1519&targetmode=cogs STRING COG0500 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0500&targetmode=cogs SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 UniProtKB TAM_ECOLI http://www.uniprot.org/uniprot/TAM_ECOLI UniProtKB-AC P76145 http://www.uniprot.org/uniprot/P76145 charge swissprot:TAM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TAM_ECOLI eggNOG COG4106 http://eggnogapi.embl.de/nog_data/html/tree/COG4106 eggNOG ENOG4107R6G http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107R6G epestfind swissprot:TAM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TAM_ECOLI garnier swissprot:TAM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TAM_ECOLI helixturnhelix swissprot:TAM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TAM_ECOLI hmoment swissprot:TAM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TAM_ECOLI iep swissprot:TAM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TAM_ECOLI inforesidue swissprot:TAM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TAM_ECOLI octanol swissprot:TAM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TAM_ECOLI pepcoil swissprot:TAM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TAM_ECOLI pepdigest swissprot:TAM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TAM_ECOLI pepinfo swissprot:TAM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TAM_ECOLI pepnet swissprot:TAM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TAM_ECOLI pepstats swissprot:TAM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TAM_ECOLI pepwheel swissprot:TAM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TAM_ECOLI pepwindow swissprot:TAM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TAM_ECOLI sigcleave swissprot:TAM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TAM_ECOLI ## Database ID URL or Descriptions # AltName ASPG1_ECOLI L-asparaginase I # AltName ASPG1_ECOLI L-asparagine amidohydrolase I # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters KM=3.5 mM for L-asparagine; # BioGrid 4259141 6 # CATALYTIC ACTIVITY L-asparagine + H(2)O = L-aspartate + NH(3). {ECO:0000269|PubMed 17451745}. # ENZYME REGULATION Shows cooperative activation. Allosterically activated by asparagine. {ECO:0000269|PubMed 17451745}. # EcoGene EG10045 ansA # GO_component GO:0005737 cytoplasm; IDA:EcoCyc. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004067 asparaginase activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0033345 asparagine catabolic process via L-aspartate; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.50.1170 -; 1. # Gene3D 3.40.50.40 -; 1. # IntAct P0A962 6 # InterPro IPR006033 AsnASEI # InterPro IPR006034 Asparaginase/glutaminase # InterPro IPR020827 Asparaginase/glutaminase_AS1 # InterPro IPR027473 L-asparaginase_C # InterPro IPR027474 L-asparaginase_N # InterPro IPR027475 Asparaginase/glutaminase_AS2 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00250 Alanine, aspartate and glutamate metabolism # KEGG_Pathway ko00460 Cyanoamino acid metabolism # KEGG_Pathway ko00910 Nitrogen metabolism # MISCELLANEOUS E.coli contains two L-asparaginase isoenzymes L- asparaginase I, a low-affinity enzyme located in the cytoplasm, and L-asparaginase II, a high-affinity secreted enzyme. # Organism ASPG1_ECOLI Escherichia coli (strain K12) # PATRIC 32118845 VBIEscCol129921_1840 # PDB 2HIM X-ray; 1.82 A; A/B/C/D=1-338 # PDB 2P2D X-ray; 1.89 A; A/B/C/D=1-338 # PDB 2P2N X-ray; 1.90 A; A/B/C/D=1-338 # PIR G64936 XDEC1 # PIRSF PIRSF001220 L-ASNase_gatD # PRINTS PR00139 ASNGLNASE # PROSITE PS00144 ASN_GLN_ASE_1 # PROSITE PS00917 ASN_GLN_ASE_2 # PROSITE PS51732 ASN_GLN_ASE_3 # Pfam PF00710 Asparaginase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ASPG1_ECOLI L-asparaginase 1 # RefSeq NP_416281 NC_000913.3 # RefSeq WP_001170162 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA23446.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the asparaginase 1 family. {ECO 0000305}. # SIMILARITY Contains 1 asparaginase/glutaminase domain. {ECO:0000255|PROSITE-ProRule PRU01068}. # SMART SM00870 Asparaginase # SUBCELLULAR LOCATION ASPG1_ECOLI Cytoplasm. # SUBUNIT Homotetramer. {ECO:0000269|PubMed 17451745}. # SUPFAM SSF53774 SSF53774 # TIGRFAMs TIGR00519 asnASE_I # eggNOG COG0252 LUCA # eggNOG ENOG4105HDK Bacteria BLAST swissprot:ASPG1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ASPG1_ECOLI BioCyc ECOL316407:JW1756-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1756-MONOMER BioCyc EcoCyc:ANSA-MONOMER http://biocyc.org/getid?id=EcoCyc:ANSA-MONOMER BioCyc MetaCyc:ANSA-MONOMER http://biocyc.org/getid?id=MetaCyc:ANSA-MONOMER COG COG0252 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0252 DIP DIP-9109N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9109N DOI 10.1016/0378-1119(89)90312-0 http://dx.doi.org/10.1016/0378-1119(89)90312-0 DOI 10.1016/j.jmb.2007.03.061 http://dx.doi.org/10.1016/j.jmb.2007.03.061 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.5.1.1 http://www.genome.jp/dbget-bin/www_bget?EC:3.5.1.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M26934 http://www.ebi.ac.uk/ena/data/view/M26934 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.5.1.1 http://enzyme.expasy.org/EC/3.5.1.1 EchoBASE EB0043 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0043 EcoGene EG10045 http://www.ecogene.org/geneInfo.php?eg_id=EG10045 EnsemblBacteria AAC74837 http://www.ensemblgenomes.org/id/AAC74837 EnsemblBacteria AAC74837 http://www.ensemblgenomes.org/id/AAC74837 EnsemblBacteria BAA15558 http://www.ensemblgenomes.org/id/BAA15558 EnsemblBacteria BAA15558 http://www.ensemblgenomes.org/id/BAA15558 EnsemblBacteria BAA15558 http://www.ensemblgenomes.org/id/BAA15558 EnsemblBacteria b1767 http://www.ensemblgenomes.org/id/b1767 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004067 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004067 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0033345 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033345 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.50.1170 http://www.cathdb.info/version/latest/superfamily/3.40.50.1170 Gene3D 3.40.50.40 http://www.cathdb.info/version/latest/superfamily/3.40.50.40 GeneID 946278 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946278 HOGENOM HOG000227974 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000227974&db=HOGENOM6 InParanoid P0A962 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A962 IntAct P0A962 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A962* IntEnz 3.5.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.1.1 InterPro IPR006033 http://www.ebi.ac.uk/interpro/entry/IPR006033 InterPro IPR006034 http://www.ebi.ac.uk/interpro/entry/IPR006034 InterPro IPR020827 http://www.ebi.ac.uk/interpro/entry/IPR020827 InterPro IPR027473 http://www.ebi.ac.uk/interpro/entry/IPR027473 InterPro IPR027474 http://www.ebi.ac.uk/interpro/entry/IPR027474 InterPro IPR027475 http://www.ebi.ac.uk/interpro/entry/IPR027475 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1756 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1756 KEGG_Gene eco:b1767 http://www.genome.jp/dbget-bin/www_bget?eco:b1767 KEGG_Orthology KO:K01424 http://www.genome.jp/dbget-bin/www_bget?KO:K01424 KEGG_Pathway ko00250 http://www.genome.jp/kegg-bin/show_pathway?ko00250 KEGG_Pathway ko00460 http://www.genome.jp/kegg-bin/show_pathway?ko00460 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Reaction rn:R00485 http://www.genome.jp/dbget-bin/www_bget?rn:R00485 OMA MPEFYHD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MPEFYHD PDB 2HIM http://www.ebi.ac.uk/pdbe-srv/view/entry/2HIM PDB 2P2D http://www.ebi.ac.uk/pdbe-srv/view/entry/2P2D PDB 2P2N http://www.ebi.ac.uk/pdbe-srv/view/entry/2P2N PDBsum 2HIM http://www.ebi.ac.uk/pdbsum/2HIM PDBsum 2P2D http://www.ebi.ac.uk/pdbsum/2P2D PDBsum 2P2N http://www.ebi.ac.uk/pdbsum/2P2N PRINTS PR00139 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00139 PROSITE PS00144 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00144 PROSITE PS00917 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00917 PROSITE PS51732 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51732 PSORT swissprot:ASPG1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ASPG1_ECOLI PSORT-B swissprot:ASPG1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ASPG1_ECOLI PSORT2 swissprot:ASPG1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ASPG1_ECOLI Pfam PF00710 http://pfam.xfam.org/family/PF00710 Phobius swissprot:ASPG1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ASPG1_ECOLI PhylomeDB P0A962 http://phylomedb.org/?seqid=P0A962 ProteinModelPortal P0A962 http://www.proteinmodelportal.org/query/uniprot/P0A962 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17451745 http://www.ncbi.nlm.nih.gov/pubmed/17451745 PubMed 2670682 http://www.ncbi.nlm.nih.gov/pubmed/2670682 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416281 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416281 RefSeq WP_001170162 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001170162 SMART SM00870 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00870 SMR P0A962 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A962 STRING 511145.b1767 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1767&targetmode=cogs STRING COG0252 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0252&targetmode=cogs SUPFAM SSF53774 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53774 TIGRFAMs TIGR00519 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00519 UniProtKB ASPG1_ECOLI http://www.uniprot.org/uniprot/ASPG1_ECOLI UniProtKB-AC P0A962 http://www.uniprot.org/uniprot/P0A962 charge swissprot:ASPG1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ASPG1_ECOLI eggNOG COG0252 http://eggnogapi.embl.de/nog_data/html/tree/COG0252 eggNOG ENOG4105HDK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105HDK epestfind swissprot:ASPG1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ASPG1_ECOLI garnier swissprot:ASPG1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ASPG1_ECOLI helixturnhelix swissprot:ASPG1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ASPG1_ECOLI hmoment swissprot:ASPG1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ASPG1_ECOLI iep swissprot:ASPG1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ASPG1_ECOLI inforesidue swissprot:ASPG1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ASPG1_ECOLI octanol swissprot:ASPG1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ASPG1_ECOLI pepcoil swissprot:ASPG1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ASPG1_ECOLI pepdigest swissprot:ASPG1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ASPG1_ECOLI pepinfo swissprot:ASPG1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ASPG1_ECOLI pepnet swissprot:ASPG1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ASPG1_ECOLI pepstats swissprot:ASPG1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ASPG1_ECOLI pepwheel swissprot:ASPG1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ASPG1_ECOLI pepwindow swissprot:ASPG1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ASPG1_ECOLI sigcleave swissprot:ASPG1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ASPG1_ECOLI ## Database ID URL or Descriptions # BRENDA 3.6.3.19 2026 # BioGrid 4262662 8 # CATALYTIC ACTIVITY ATP + H(2)O + maltose(Out) = ADP + phosphate + maltose(In). {ECO:0000255|HAMAP-Rule MF_01709}. # EcoGene EG10558 malK # FUNCTION MALK_ECOLI Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Responsible for energy coupling to the transport system. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_component GO:0031234 extrinsic component of cytoplasmic side of plasma membrane; IDA:EcoCyc. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IDA:EcoCyc. # GO_component GO:1990060 maltose transport complex; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IDA:EcoCyc. # GO_function GO:0015423 maltose-transporting ATPase activity; IDA:EcoCyc. # GO_function GO:0015609 maltooligosaccharide-importing ATPase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0033613 activating transcription factor binding; IPI:EcoCyc. # GO_process GO:0015768 maltose transport; IDA:EcoCyc. # GO_process GO:0042956 maltodextrin transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043234 protein complex # GOslim_function GO:0008134 transcription factor binding # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # Gene3D 3.40.50.300 -; 1. # IntAct P68187 8 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR008995 Mo/tungstate-bd_C_term_dom # InterPro IPR013611 Transp-assoc_OB_typ2 # InterPro IPR015855 ABC_transpr_MalK # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00194 Maltose/maltodextrin transport system # KEGG_Brite ko02000 M00197 Putative fructooligosaccharide transport system # KEGG_Brite ko02000 M00491 Putative arabinogalactan oligomer transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # MISCELLANEOUS MALK_ECOLI Acts as a repressor of mal genes. In absence of maltose, the C-terminus of MalK interacts with MalT, then MalT becomes inactive and the mal genes are not activated. In presence of maltose, MalK is tightly associated with the MalFG complex and has no affinity for MalT. # MISCELLANEOUS MALK_ECOLI Target for inducer exclusion, mediated by the unphosphorylated enzyme III of the phosphotransferase system for glucose and resulting in the inhibition of maltose transport. # Organism MALK_ECOLI Escherichia coli (strain K12) # PATRIC 32123603 VBIEscCol129921_4150 # PDB 1Q12 X-ray; 2.60 A; A/B/C/D=1-371 # PDB 1Q1B X-ray; 2.80 A; A/B/C/D=1-371 # PDB 1Q1E X-ray; 2.90 A; A/B=1-371 # PDB 2AWN X-ray; 2.30 A; A/B/C/D=1-371 # PDB 2AWO X-ray; 2.80 A; A/B/C/D=1-371 # PDB 2R6G X-ray; 2.80 A; A/B=1-371 # PDB 3FH6 X-ray; 4.50 A; A/B/C/D=1-371 # PDB 3GD7 X-ray; 2.70 A; A/B/C/D=219-371 # PDB 3PUV X-ray; 2.40 A; A/B=1-371 # PDB 3PUW X-ray; 2.30 A; A/B=1-371 # PDB 3PUX X-ray; 2.30 A; A/B=1-371 # PDB 3PUY X-ray; 3.10 A; A/B=1-371 # PDB 3PUZ X-ray; 2.90 A; A/B=1-371 # PDB 3PV0 X-ray; 3.10 A; A/B=1-371 # PDB 3RLF X-ray; 2.20 A; A/B=1-371 # PDB 4JBW X-ray; 3.91 A; A/B/C/D=1-371 # PDB 4KI0 X-ray; 2.38 A; A/B=1-371 # PIR B65211 MMECMK # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # PROSITE PS51245 MALK # Pfam PF00005 ABC_tran # Pfam PF08402 TOBE_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Maltose/maltodextrin import ATP-binding protein MalK {ECO:0000255|HAMAP-Rule MF_01709} # RefSeq NP_418459 NC_000913.3 # RefSeq WP_000179165 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA23582.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ABC transporter superfamily. Maltooligosaccharide importer (TC 3.A.1.1.1) family. {ECO:0000255|HAMAP-Rule MF_01709}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|HAMAP- Rule MF_01709}. # SMART SM00382 AAA # SUBCELLULAR LOCATION MALK_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01709, ECO 0000269|PubMed 16079137, ECO 0000269|PubMed 18456666}; Peripheral membrane protein {ECO 0000255|HAMAP-Rule MF_01709, ECO 0000269|PubMed 16079137, ECO 0000269|PubMed 18456666}. # SUBUNIT The complex is composed of two ATP-binding proteins (MalK), two transmembrane proteins (MalG and MalF) and a solute- binding protein (MalE). Protein stability and stable complex formation require YidC. {ECO:0000269|PubMed 18456666}. # SUPFAM SSF50331 SSF50331 # SUPFAM SSF52540 SSF52540 # TCDB 3.A.1.1 the atp-binding cassette (abc) superfamily # eggNOG COG3839 LUCA # eggNOG ENOG4108IJ9 Bacteria BLAST swissprot:MALK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MALK_ECOLI BioCyc ECOL316407:JW3995-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3995-MONOMER BioCyc EcoCyc:MALK-MONOMER http://biocyc.org/getid?id=EcoCyc:MALK-MONOMER BioCyc MetaCyc:MALK-MONOMER http://biocyc.org/getid?id=MetaCyc:MALK-MONOMER COG COG3839 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3839 DIP DIP-47850N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47850N DOI 10.1007/BF00331269 http://dx.doi.org/10.1007/BF00331269 DOI 10.1007/BF00333794 http://dx.doi.org/10.1007/BF00333794 DOI 10.1016/j.molcel.2003.08.004 http://dx.doi.org/10.1016/j.molcel.2003.08.004 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1998.01084.x http://dx.doi.org/10.1046/j.1365-2958.1998.01084.x DOI 10.1074/jbc.275.20.15526 http://dx.doi.org/10.1074/jbc.275.20.15526 DOI 10.1074/jbc.M107905200 http://dx.doi.org/10.1074/jbc.M107905200 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1074/jbc.M801481200 http://dx.doi.org/10.1074/jbc.M801481200 DOI 10.1093/emboj/16.11.3066 http://dx.doi.org/10.1093/emboj/16.11.3066 DOI 10.1093/nar/10.22.7449 http://dx.doi.org/10.1093/nar/10.22.7449 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.3.19 {ECO:0000255|HAMAP-Rule:MF_01709} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.19 {ECO:0000255|HAMAP-Rule:MF_01709} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01648 http://www.ebi.ac.uk/ena/data/view/J01648 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00303 http://www.ebi.ac.uk/ena/data/view/V00303 ENZYME 3.6.3.19 {ECO:0000255|HAMAP-Rule:MF_01709} http://enzyme.expasy.org/EC/3.6.3.19 {ECO:0000255|HAMAP-Rule:MF_01709} EchoBASE EB0553 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0553 EcoGene EG10558 http://www.ecogene.org/geneInfo.php?eg_id=EG10558 EnsemblBacteria AAC77005 http://www.ensemblgenomes.org/id/AAC77005 EnsemblBacteria AAC77005 http://www.ensemblgenomes.org/id/AAC77005 EnsemblBacteria BAE78037 http://www.ensemblgenomes.org/id/BAE78037 EnsemblBacteria BAE78037 http://www.ensemblgenomes.org/id/BAE78037 EnsemblBacteria BAE78037 http://www.ensemblgenomes.org/id/BAE78037 EnsemblBacteria b4035 http://www.ensemblgenomes.org/id/b4035 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0031234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031234 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_component GO:1990060 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990060 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0015423 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015423 GO_function GO:0015609 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015609 GO_function GO:0033613 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033613 GO_process GO:0015768 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015768 GO_process GO:0042956 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042956 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0008134 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008134 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948537 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948537 InParanoid P68187 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P68187 IntAct P68187 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P68187* IntEnz 3.6.3.19 {ECO:0000255|HAMAP-Rule:MF_01709} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.19 {ECO:0000255|HAMAP-Rule:MF_01709} InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR008995 http://www.ebi.ac.uk/interpro/entry/IPR008995 InterPro IPR013611 http://www.ebi.ac.uk/interpro/entry/IPR013611 InterPro IPR015855 http://www.ebi.ac.uk/interpro/entry/IPR015855 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3995 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3995 KEGG_Gene eco:b4035 http://www.genome.jp/dbget-bin/www_bget?eco:b4035 KEGG_Orthology KO:K10111 http://www.genome.jp/dbget-bin/www_bget?KO:K10111 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 MINT MINT-1223477 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1223477 OMA VPERCHL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VPERCHL PDB 1Q12 http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q12 PDB 1Q1B http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q1B PDB 1Q1E http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q1E PDB 2AWN http://www.ebi.ac.uk/pdbe-srv/view/entry/2AWN PDB 2AWO http://www.ebi.ac.uk/pdbe-srv/view/entry/2AWO PDB 2R6G http://www.ebi.ac.uk/pdbe-srv/view/entry/2R6G PDB 3FH6 http://www.ebi.ac.uk/pdbe-srv/view/entry/3FH6 PDB 3GD7 http://www.ebi.ac.uk/pdbe-srv/view/entry/3GD7 PDB 3PUV http://www.ebi.ac.uk/pdbe-srv/view/entry/3PUV PDB 3PUW http://www.ebi.ac.uk/pdbe-srv/view/entry/3PUW PDB 3PUX http://www.ebi.ac.uk/pdbe-srv/view/entry/3PUX PDB 3PUY http://www.ebi.ac.uk/pdbe-srv/view/entry/3PUY PDB 3PUZ http://www.ebi.ac.uk/pdbe-srv/view/entry/3PUZ PDB 3PV0 http://www.ebi.ac.uk/pdbe-srv/view/entry/3PV0 PDB 3RLF http://www.ebi.ac.uk/pdbe-srv/view/entry/3RLF PDB 4JBW http://www.ebi.ac.uk/pdbe-srv/view/entry/4JBW PDB 4KI0 http://www.ebi.ac.uk/pdbe-srv/view/entry/4KI0 PDBsum 1Q12 http://www.ebi.ac.uk/pdbsum/1Q12 PDBsum 1Q1B http://www.ebi.ac.uk/pdbsum/1Q1B PDBsum 1Q1E http://www.ebi.ac.uk/pdbsum/1Q1E PDBsum 2AWN http://www.ebi.ac.uk/pdbsum/2AWN PDBsum 2AWO http://www.ebi.ac.uk/pdbsum/2AWO PDBsum 2R6G http://www.ebi.ac.uk/pdbsum/2R6G PDBsum 3FH6 http://www.ebi.ac.uk/pdbsum/3FH6 PDBsum 3GD7 http://www.ebi.ac.uk/pdbsum/3GD7 PDBsum 3PUV http://www.ebi.ac.uk/pdbsum/3PUV PDBsum 3PUW http://www.ebi.ac.uk/pdbsum/3PUW PDBsum 3PUX http://www.ebi.ac.uk/pdbsum/3PUX PDBsum 3PUY http://www.ebi.ac.uk/pdbsum/3PUY PDBsum 3PUZ http://www.ebi.ac.uk/pdbsum/3PUZ PDBsum 3PV0 http://www.ebi.ac.uk/pdbsum/3PV0 PDBsum 3RLF http://www.ebi.ac.uk/pdbsum/3RLF PDBsum 4JBW http://www.ebi.ac.uk/pdbsum/4JBW PDBsum 4KI0 http://www.ebi.ac.uk/pdbsum/4KI0 PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PROSITE PS51245 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51245 PSORT swissprot:MALK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MALK_ECOLI PSORT-B swissprot:MALK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MALK_ECOLI PSORT2 swissprot:MALK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MALK_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Pfam PF08402 http://pfam.xfam.org/family/PF08402 Phobius swissprot:MALK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MALK_ECOLI PhylomeDB P68187 http://phylomedb.org/?seqid=P68187 ProteinModelPortal P68187 http://www.proteinmodelportal.org/query/uniprot/P68187 PubMed 10809785 http://www.ncbi.nlm.nih.gov/pubmed/10809785 PubMed 11709552 http://www.ncbi.nlm.nih.gov/pubmed/11709552 PubMed 14527411 http://www.ncbi.nlm.nih.gov/pubmed/14527411 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18456666 http://www.ncbi.nlm.nih.gov/pubmed/18456666 PubMed 2007546 http://www.ncbi.nlm.nih.gov/pubmed/2007546 PubMed 2026607 http://www.ncbi.nlm.nih.gov/pubmed/2026607 PubMed 2155217 http://www.ncbi.nlm.nih.gov/pubmed/2155217 PubMed 2250006 http://www.ncbi.nlm.nih.gov/pubmed/2250006 PubMed 2674653 http://www.ncbi.nlm.nih.gov/pubmed/2674653 PubMed 6283312 http://www.ncbi.nlm.nih.gov/pubmed/6283312 PubMed 6296778 http://www.ncbi.nlm.nih.gov/pubmed/6296778 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9214624 http://www.ncbi.nlm.nih.gov/pubmed/9214624 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9529892 http://www.ncbi.nlm.nih.gov/pubmed/9529892 PubMed 9822819 http://www.ncbi.nlm.nih.gov/pubmed/9822819 RefSeq NP_418459 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418459 RefSeq WP_000179165 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000179165 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P68187 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P68187 STRING 511145.b4035 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4035&targetmode=cogs STRING COG3839 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3839&targetmode=cogs SUPFAM SSF50331 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50331 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.1 http://www.tcdb.org/search/result.php?tc=3.A.1.1 UniProtKB MALK_ECOLI http://www.uniprot.org/uniprot/MALK_ECOLI UniProtKB-AC P68187 http://www.uniprot.org/uniprot/P68187 charge swissprot:MALK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MALK_ECOLI eggNOG COG3839 http://eggnogapi.embl.de/nog_data/html/tree/COG3839 eggNOG ENOG4108IJ9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108IJ9 epestfind swissprot:MALK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MALK_ECOLI garnier swissprot:MALK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MALK_ECOLI helixturnhelix swissprot:MALK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MALK_ECOLI hmoment swissprot:MALK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MALK_ECOLI iep swissprot:MALK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MALK_ECOLI inforesidue swissprot:MALK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MALK_ECOLI octanol swissprot:MALK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MALK_ECOLI pepcoil swissprot:MALK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MALK_ECOLI pepdigest swissprot:MALK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MALK_ECOLI pepinfo swissprot:MALK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MALK_ECOLI pepnet swissprot:MALK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MALK_ECOLI pepstats swissprot:MALK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MALK_ECOLI pepwheel swissprot:MALK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MALK_ECOLI pepwindow swissprot:MALK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MALK_ECOLI sigcleave swissprot:MALK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MALK_ECOLI ## Database ID URL or Descriptions # BioGrid 4263009 10 # EcoGene EG14150 ypdC # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0000987 core promoter proximal region sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IBA:GO_Central. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.60 -; 2. # IntAct P77396 8 # InterPro IPR009057 Homeodomain-like # InterPro IPR018060 HTH_AraC # InterPro IPR018062 HTH_AraC-typ_CS # InterPro IPR020449 Tscrpt_reg_HTH_AraC-type # Organism YPDC_ECOLI Escherichia coli (strain K12) # PATRIC 32120143 VBIEscCol129921_2480 # PIR C65012 C65012 # PRINTS PR00032 HTHARAC # PROSITE PS00041 HTH_ARAC_FAMILY_1 # PROSITE PS01124 HTH_ARAC_FAMILY_2 # Pfam PF12833 HTH_18 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YPDC_ECOLI Uncharacterized HTH-type transcriptional regulator YpdC # RefSeq NP_416883 NC_000913.3 # RefSeq WP_000646835 NZ_LN832404.1 # SIMILARITY Contains 1 HTH araC/xylS-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00593}. # SMART SM00342 HTH_ARAC # SUPFAM SSF46689 SSF46689; 2 # eggNOG ENOG4108CIP Bacteria # eggNOG ENOG410XTD9 LUCA BLAST swissprot:YPDC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YPDC_ECOLI BioCyc ECOL316407:JW2379-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2379-MONOMER BioCyc EcoCyc:G7245-MONOMER http://biocyc.org/getid?id=EcoCyc:G7245-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3902 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3902 EcoGene EG14150 http://www.ecogene.org/geneInfo.php?eg_id=EG14150 EnsemblBacteria AAC75441 http://www.ensemblgenomes.org/id/AAC75441 EnsemblBacteria AAC75441 http://www.ensemblgenomes.org/id/AAC75441 EnsemblBacteria BAA16252 http://www.ensemblgenomes.org/id/BAA16252 EnsemblBacteria BAA16252 http://www.ensemblgenomes.org/id/BAA16252 EnsemblBacteria BAA16252 http://www.ensemblgenomes.org/id/BAA16252 EnsemblBacteria b2382 http://www.ensemblgenomes.org/id/b2382 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000987 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000987 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 GeneID 946856 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946856 HOGENOM HOG000274763 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000274763&db=HOGENOM6 InParanoid P77396 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77396 IntAct P77396 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77396* InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR018060 http://www.ebi.ac.uk/interpro/entry/IPR018060 InterPro IPR018062 http://www.ebi.ac.uk/interpro/entry/IPR018062 InterPro IPR020449 http://www.ebi.ac.uk/interpro/entry/IPR020449 KEGG_Gene ecj:JW2379 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2379 KEGG_Gene eco:b2382 http://www.genome.jp/dbget-bin/www_bget?eco:b2382 OMA HRPITRD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HRPITRD PRINTS PR00032 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00032 PROSITE PS00041 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00041 PROSITE PS01124 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01124 PSORT swissprot:YPDC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YPDC_ECOLI PSORT-B swissprot:YPDC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YPDC_ECOLI PSORT2 swissprot:YPDC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YPDC_ECOLI Pfam PF12833 http://pfam.xfam.org/family/PF12833 Phobius swissprot:YPDC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YPDC_ECOLI PhylomeDB P77396 http://phylomedb.org/?seqid=P77396 ProteinModelPortal P77396 http://www.proteinmodelportal.org/query/uniprot/P77396 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416883 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416883 RefSeq WP_000646835 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000646835 SMART SM00342 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00342 SMR P77396 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77396 STRING 511145.b2382 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2382&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 UniProtKB YPDC_ECOLI http://www.uniprot.org/uniprot/YPDC_ECOLI UniProtKB-AC P77396 http://www.uniprot.org/uniprot/P77396 charge swissprot:YPDC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YPDC_ECOLI eggNOG ENOG4108CIP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108CIP eggNOG ENOG410XTD9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XTD9 epestfind swissprot:YPDC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YPDC_ECOLI garnier swissprot:YPDC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YPDC_ECOLI helixturnhelix swissprot:YPDC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YPDC_ECOLI hmoment swissprot:YPDC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YPDC_ECOLI iep swissprot:YPDC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YPDC_ECOLI inforesidue swissprot:YPDC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YPDC_ECOLI octanol swissprot:YPDC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YPDC_ECOLI pepcoil swissprot:YPDC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YPDC_ECOLI pepdigest swissprot:YPDC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YPDC_ECOLI pepinfo swissprot:YPDC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YPDC_ECOLI pepnet swissprot:YPDC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YPDC_ECOLI pepstats swissprot:YPDC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YPDC_ECOLI pepwheel swissprot:YPDC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YPDC_ECOLI pepwindow swissprot:YPDC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YPDC_ECOLI sigcleave swissprot:YPDC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YPDC_ECOLI ## Database ID URL or Descriptions # BioGrid 4259446 21 # EcoGene EG13830 ydfR # IntAct P76160 4 # InterPro IPR009759 Phage_ES18_Gp24 # Organism YDFR_ECOLI Escherichia coli (strain K12) # PATRIC 32118412 VBIEscCol129921_1626 # PIR F64910 F64910 # Pfam PF07041 DUF1327 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDFR_ECOLI Uncharacterized protein YdfR # RefSeq NP_416073 NC_000913.3 # RefSeq WP_000189916 NZ_LN832404.1 BLAST swissprot:YDFR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDFR_ECOLI BioCyc ECOL316407:JW1547-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1547-MONOMER BioCyc EcoCyc:G6828-MONOMER http://biocyc.org/getid?id=EcoCyc:G6828-MONOMER DIP DIP-11703N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11703N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3591 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3591 EcoGene EG13830 http://www.ecogene.org/geneInfo.php?eg_id=EG13830 EnsemblBacteria AAC74628 http://www.ensemblgenomes.org/id/AAC74628 EnsemblBacteria AAC74628 http://www.ensemblgenomes.org/id/AAC74628 EnsemblBacteria BAE76470 http://www.ensemblgenomes.org/id/BAE76470 EnsemblBacteria BAE76470 http://www.ensemblgenomes.org/id/BAE76470 EnsemblBacteria BAE76470 http://www.ensemblgenomes.org/id/BAE76470 EnsemblBacteria b1555 http://www.ensemblgenomes.org/id/b1555 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946095 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946095 HOGENOM HOG000050872 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000050872&db=HOGENOM6 IntAct P76160 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76160* InterPro IPR009759 http://www.ebi.ac.uk/interpro/entry/IPR009759 KEGG_Gene ecj:JW1547 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1547 KEGG_Gene eco:b1555 http://www.genome.jp/dbget-bin/www_bget?eco:b1555 PSORT swissprot:YDFR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDFR_ECOLI PSORT-B swissprot:YDFR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDFR_ECOLI PSORT2 swissprot:YDFR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDFR_ECOLI Pfam PF07041 http://pfam.xfam.org/family/PF07041 Phobius swissprot:YDFR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDFR_ECOLI ProteinModelPortal P76160 http://www.proteinmodelportal.org/query/uniprot/P76160 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416073 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416073 RefSeq WP_000189916 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000189916 STRING 511145.b1555 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1555&targetmode=cogs UniProtKB YDFR_ECOLI http://www.uniprot.org/uniprot/YDFR_ECOLI UniProtKB-AC P76160 http://www.uniprot.org/uniprot/P76160 charge swissprot:YDFR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDFR_ECOLI epestfind swissprot:YDFR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDFR_ECOLI garnier swissprot:YDFR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDFR_ECOLI helixturnhelix swissprot:YDFR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDFR_ECOLI hmoment swissprot:YDFR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDFR_ECOLI iep swissprot:YDFR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDFR_ECOLI inforesidue swissprot:YDFR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDFR_ECOLI octanol swissprot:YDFR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDFR_ECOLI pepcoil swissprot:YDFR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDFR_ECOLI pepdigest swissprot:YDFR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDFR_ECOLI pepinfo swissprot:YDFR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDFR_ECOLI pepnet swissprot:YDFR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDFR_ECOLI pepstats swissprot:YDFR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDFR_ECOLI pepwheel swissprot:YDFR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDFR_ECOLI pepwindow swissprot:YDFR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDFR_ECOLI sigcleave swissprot:YDFR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDFR_ECOLI ## Database ID URL or Descriptions # AltName DNLJ_ECOLI Polydeoxyribonucleotide synthase [NAD(+)] # BRENDA 6.5.1 2026 # BioGrid 4259672 128 # CATALYTIC ACTIVITY NAD(+) + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + beta-nicotinamide D- ribonucleotide + (deoxyribonucleotide)(n+m). {ECO:0000269|PubMed 11781321}. # CDD cd00027 BRCT # COFACTOR DNLJ_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 11781321}; # EcoGene EG10534 ligA # FUNCTION DNLJ_ECOLI DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0003911 DNA ligase (NAD+) activity; IDA:EcoliWiki. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0070403 NAD+ binding; IMP:EcoCyc. # GO_process GO:0006260 DNA replication; IEA:UniProtKB-KW. # GO_process GO:0006266 DNA ligation; IDA:EcoCyc. # GO_process GO:0006288 base-excision repair, DNA ligation; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.10190 -; 1. # HAMAP MF_01588 DNA_ligase_A # IntAct P15042 20 # InterPro IPR001357 BRCT_dom # InterPro IPR001679 DNAligase # InterPro IPR003583 Hlx-hairpin-Hlx_DNA-bd_motif # InterPro IPR004149 Znf_DNAligase_C4 # InterPro IPR004150 NAD_DNA_ligase_OB # InterPro IPR010994 RuvA_2-like # InterPro IPR012340 NA-bd_OB-fold # InterPro IPR013839 DNAligase_adenylation # InterPro IPR013840 DNAligase_N # InterPro IPR018239 DNA_ligase_AS # InterPro IPR033136 DNA_ligase_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03032 DNA replication proteins # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko03030 DNA replication # KEGG_Pathway ko03410 Base excision repair # KEGG_Pathway ko03420 Nucleotide excision repair # KEGG_Pathway ko03430 Mismatch repair # Organism DNLJ_ECOLI Escherichia coli (strain K12) # PATRIC 32120205 VBIEscCol129921_2505 # PDB 2OWO X-ray; 2.30 A; A=1-671 # PDB 4GLX X-ray; 1.90 A; A=1-586 # PIR B65015 LQECC6 # PIRSF PIRSF001604 LigA # PROSITE PS01055 DNA_LIGASE_N1 # PROSITE PS01056 DNA_LIGASE_N2 # PROSITE PS50172 BRCT # Pfam PF00533 BRCT # Pfam PF01653 DNA_ligase_aden # Pfam PF03119 DNA_ligase_ZBD # Pfam PF03120 DNA_ligase_OB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DNLJ_ECOLI DNA ligase # RefSeq NP_416906 NC_000913.3 # RefSeq WP_000443661 NZ_LN832404.1 # SIMILARITY Belongs to the NAD-dependent DNA ligase family. LigA subfamily. {ECO 0000305}. # SIMILARITY Contains 1 BRCT domain. {ECO 0000305}. # SMART SM00278 HhH1; 4 # SMART SM00292 BRCT # SMART SM00532 LIGANc # SUPFAM SSF47781 SSF47781 # SUPFAM SSF50249 SSF50249 # SUPFAM SSF52113 SSF52113 # TIGRFAMs TIGR00575 dnlj # eggNOG COG0272 LUCA # eggNOG ENOG4105C77 Bacteria BLAST swissprot:DNLJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DNLJ_ECOLI BioCyc ECOL316407:JW2403-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2403-MONOMER BioCyc EcoCyc:EG10534-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10534-MONOMER BioCyc MetaCyc:EG10534-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10534-MONOMER COG COG0272 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0272 DIP DIP-10098N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10098N DOI 10.1007/BF00330179 http://dx.doi.org/10.1007/BF00330179 DOI 10.1016/S0092-8674(00)81838-3 http://dx.doi.org/10.1016/S0092-8674(00)81838-3 DOI 10.1016/j.molcel.2007.02.026 http://dx.doi.org/10.1016/j.molcel.2007.02.026 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M111164200 http://dx.doi.org/10.1074/jbc.M111164200 DOI 10.1074/jbc.M413685200 http://dx.doi.org/10.1074/jbc.M413685200 DOI 10.1074/jbc.M802945200 http://dx.doi.org/10.1074/jbc.M802945200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.5.1.2 http://www.genome.jp/dbget-bin/www_bget?EC:6.5.1.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M24278 http://www.ebi.ac.uk/ena/data/view/M24278 EMBL M30255 http://www.ebi.ac.uk/ena/data/view/M30255 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U74650 http://www.ebi.ac.uk/ena/data/view/U74650 ENZYME 6.5.1.2 http://enzyme.expasy.org/EC/6.5.1.2 EchoBASE EB0529 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0529 EcoGene EG10534 http://www.ecogene.org/geneInfo.php?eg_id=EG10534 EnsemblBacteria AAC75464 http://www.ensemblgenomes.org/id/AAC75464 EnsemblBacteria AAC75464 http://www.ensemblgenomes.org/id/AAC75464 EnsemblBacteria BAA16282 http://www.ensemblgenomes.org/id/BAA16282 EnsemblBacteria BAA16282 http://www.ensemblgenomes.org/id/BAA16282 EnsemblBacteria BAA16282 http://www.ensemblgenomes.org/id/BAA16282 EnsemblBacteria b2411 http://www.ensemblgenomes.org/id/b2411 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003911 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003911 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0070403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070403 GO_process GO:0006260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260 GO_process GO:0006266 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006266 GO_process GO:0006288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006288 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.10190 http://www.cathdb.info/version/latest/superfamily/3.40.50.10190 GeneID 946885 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946885 HAMAP MF_01588 http://hamap.expasy.org/unirule/MF_01588 HOGENOM HOG000218459 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218459&db=HOGENOM6 InParanoid P15042 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P15042 IntAct P15042 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P15042* IntEnz 6.5.1.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.5.1.2 InterPro IPR001357 http://www.ebi.ac.uk/interpro/entry/IPR001357 InterPro IPR001679 http://www.ebi.ac.uk/interpro/entry/IPR001679 InterPro IPR003583 http://www.ebi.ac.uk/interpro/entry/IPR003583 InterPro IPR004149 http://www.ebi.ac.uk/interpro/entry/IPR004149 InterPro IPR004150 http://www.ebi.ac.uk/interpro/entry/IPR004150 InterPro IPR010994 http://www.ebi.ac.uk/interpro/entry/IPR010994 InterPro IPR012340 http://www.ebi.ac.uk/interpro/entry/IPR012340 InterPro IPR013839 http://www.ebi.ac.uk/interpro/entry/IPR013839 InterPro IPR013840 http://www.ebi.ac.uk/interpro/entry/IPR013840 InterPro IPR018239 http://www.ebi.ac.uk/interpro/entry/IPR018239 InterPro IPR033136 http://www.ebi.ac.uk/interpro/entry/IPR033136 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03032 http://www.genome.jp/dbget-bin/www_bget?ko03032 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW2403 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2403 KEGG_Gene eco:b2411 http://www.genome.jp/dbget-bin/www_bget?eco:b2411 KEGG_Orthology KO:K01972 http://www.genome.jp/dbget-bin/www_bget?KO:K01972 KEGG_Pathway ko03030 http://www.genome.jp/kegg-bin/show_pathway?ko03030 KEGG_Pathway ko03410 http://www.genome.jp/kegg-bin/show_pathway?ko03410 KEGG_Pathway ko03420 http://www.genome.jp/kegg-bin/show_pathway?ko03420 KEGG_Pathway ko03430 http://www.genome.jp/kegg-bin/show_pathway?ko03430 MINT MINT-204717 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-204717 OMA FTAKSPR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FTAKSPR PDB 2OWO http://www.ebi.ac.uk/pdbe-srv/view/entry/2OWO PDB 4GLX http://www.ebi.ac.uk/pdbe-srv/view/entry/4GLX PDBsum 2OWO http://www.ebi.ac.uk/pdbsum/2OWO PDBsum 4GLX http://www.ebi.ac.uk/pdbsum/4GLX PROSITE PS01055 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01055 PROSITE PS01056 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01056 PROSITE PS50172 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50172 PSORT swissprot:DNLJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DNLJ_ECOLI PSORT-B swissprot:DNLJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DNLJ_ECOLI PSORT2 swissprot:DNLJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DNLJ_ECOLI Pfam PF00533 http://pfam.xfam.org/family/PF00533 Pfam PF01653 http://pfam.xfam.org/family/PF01653 Pfam PF03119 http://pfam.xfam.org/family/PF03119 Pfam PF03120 http://pfam.xfam.org/family/PF03120 Phobius swissprot:DNLJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DNLJ_ECOLI PhylomeDB P15042 http://phylomedb.org/?seqid=P15042 ProteinModelPortal P15042 http://www.proteinmodelportal.org/query/uniprot/P15042 PubMed 11781321 http://www.ncbi.nlm.nih.gov/pubmed/11781321 PubMed 15671015 http://www.ncbi.nlm.nih.gov/pubmed/15671015 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17466627 http://www.ncbi.nlm.nih.gov/pubmed/17466627 PubMed 18515356 http://www.ncbi.nlm.nih.gov/pubmed/18515356 PubMed 3018436 http://www.ncbi.nlm.nih.gov/pubmed/3018436 PubMed 9008158 http://www.ncbi.nlm.nih.gov/pubmed/9008158 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416906 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416906 RefSeq WP_000443661 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000443661 SMART SM00278 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00278 SMART SM00292 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00292 SMART SM00532 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00532 SMR P15042 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P15042 STRING 511145.b2411 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2411&targetmode=cogs STRING COG0272 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0272&targetmode=cogs SUPFAM SSF47781 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47781 SUPFAM SSF50249 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50249 SUPFAM SSF52113 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52113 TIGRFAMs TIGR00575 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00575 UniProtKB DNLJ_ECOLI http://www.uniprot.org/uniprot/DNLJ_ECOLI UniProtKB-AC P15042 http://www.uniprot.org/uniprot/P15042 charge swissprot:DNLJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DNLJ_ECOLI eggNOG COG0272 http://eggnogapi.embl.de/nog_data/html/tree/COG0272 eggNOG ENOG4105C77 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C77 epestfind swissprot:DNLJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DNLJ_ECOLI garnier swissprot:DNLJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DNLJ_ECOLI helixturnhelix swissprot:DNLJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DNLJ_ECOLI hmoment swissprot:DNLJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DNLJ_ECOLI iep swissprot:DNLJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DNLJ_ECOLI inforesidue swissprot:DNLJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DNLJ_ECOLI octanol swissprot:DNLJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DNLJ_ECOLI pepcoil swissprot:DNLJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DNLJ_ECOLI pepdigest swissprot:DNLJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DNLJ_ECOLI pepinfo swissprot:DNLJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DNLJ_ECOLI pepnet swissprot:DNLJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DNLJ_ECOLI pepstats swissprot:DNLJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DNLJ_ECOLI pepwheel swissprot:DNLJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DNLJ_ECOLI pepwindow swissprot:DNLJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DNLJ_ECOLI sigcleave swissprot:DNLJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DNLJ_ECOLI ## Database ID URL or Descriptions # AltName GSHB_ECOLI GSH synthetase # AltName GSHB_ECOLI Glutathione synthase # BRENDA 6.3.2 2026 # BioGrid 4259406 5 # CATALYTIC ACTIVITY GSHB_ECOLI ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione. # COFACTOR GSHB_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000250}; Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit. {ECO 0000250}; # ENZYME REGULATION GSHB_ECOLI Inhibited by 7,8-dihydrofolate, methotrexate and trimethoprim. # EcoGene EG10419 gshB # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0004363 glutathione synthase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0030145 manganese ion binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006750 glutathione biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.30.1490.20 -; 1. # Gene3D 3.30.470.20 -; 1. # Gene3D 3.40.50.20 -; 1. # HAMAP MF_00162 GSH_S # IntAct P04425 5 # InterPro IPR004215 GSHS_N # InterPro IPR004218 GSHS_ATP-bd # InterPro IPR006284 Glut_synth_pro # InterPro IPR011761 ATP-grasp # InterPro IPR013815 ATP_grasp_subdomain_1 # InterPro IPR013816 ATP_grasp_subdomain_2 # InterPro IPR016185 PreATP-grasp_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00480 Glutathione metabolism # Organism GSHB_ECOLI Escherichia coli (strain K12) # PATHWAY Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate step 2/2. # PATRIC 32121304 VBIEscCol129921_3040 # PDB 1GLV X-ray; 2.70 A; A=1-316 # PDB 1GSA X-ray; 2.00 A; A=1-316 # PDB 1GSH X-ray; 2.00 A; A=1-316 # PDB 2GLT X-ray; 2.20 A; A=1-316 # PIR A01194 SYECGS # PROSITE PS50975 ATP_GRASP # Pfam PF02951 GSH-S_N # Pfam PF02955 GSH-S_ATP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GSHB_ECOLI Glutathione synthetase # RefSeq NP_417422 NC_000913.3 # RefSeq WP_000593273 NZ_LN832404.1 # SIMILARITY Belongs to the prokaryotic GSH synthase family. {ECO 0000305}. # SIMILARITY Contains 1 ATP-grasp domain. {ECO 0000305}. # SUBUNIT GSHB_ECOLI Homotetramer. # SUPFAM SSF52440 SSF52440 # TIGRFAMs TIGR01380 glut_syn # UniPathway UPA00142 UER00210 # eggNOG COG0189 LUCA # eggNOG ENOG4105D7Z Bacteria BLAST swissprot:GSHB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GSHB_ECOLI BioCyc ECOL316407:JW2914-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2914-MONOMER BioCyc EcoCyc:GLUTATHIONE-SYN-MONOMER http://biocyc.org/getid?id=EcoCyc:GLUTATHIONE-SYN-MONOMER BioCyc MetaCyc:GLUTATHIONE-SYN-MONOMER http://biocyc.org/getid?id=MetaCyc:GLUTATHIONE-SYN-MONOMER COG COG0189 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0189 DIP DIP-9840N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9840N DOI 10.1006/jmbi.1993.1106 http://dx.doi.org/10.1006/jmbi.1993.1106 DOI 10.1021/bi00097a018 http://dx.doi.org/10.1021/bi00097a018 DOI 10.1021/bi00123a007 http://dx.doi.org/10.1021/bi00123a007 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/12.24.9299 http://dx.doi.org/10.1093/nar/12.24.9299 DOI 10.1093/protein/9.12.1083 http://dx.doi.org/10.1093/protein/9.12.1083 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.3.2.3 http://www.genome.jp/dbget-bin/www_bget?EC:6.3.2.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EMBL X01666 http://www.ebi.ac.uk/ena/data/view/X01666 ENZYME 6.3.2.3 http://enzyme.expasy.org/EC/6.3.2.3 EchoBASE EB0414 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0414 EcoGene EG10419 http://www.ecogene.org/geneInfo.php?eg_id=EG10419 EnsemblBacteria AAC75984 http://www.ensemblgenomes.org/id/AAC75984 EnsemblBacteria AAC75984 http://www.ensemblgenomes.org/id/AAC75984 EnsemblBacteria BAE77010 http://www.ensemblgenomes.org/id/BAE77010 EnsemblBacteria BAE77010 http://www.ensemblgenomes.org/id/BAE77010 EnsemblBacteria BAE77010 http://www.ensemblgenomes.org/id/BAE77010 EnsemblBacteria b2947 http://www.ensemblgenomes.org/id/b2947 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0004363 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004363 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_process GO:0006750 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006750 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.30.1490.20 http://www.cathdb.info/version/latest/superfamily/3.30.1490.20 Gene3D 3.30.470.20 http://www.cathdb.info/version/latest/superfamily/3.30.470.20 Gene3D 3.40.50.20 http://www.cathdb.info/version/latest/superfamily/3.40.50.20 GeneID 947445 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947445 HAMAP MF_00162 http://hamap.expasy.org/unirule/MF_00162 HOGENOM HOG000265022 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000265022&db=HOGENOM6 InParanoid P04425 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P04425 IntAct P04425 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P04425* IntEnz 6.3.2.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.2.3 InterPro IPR004215 http://www.ebi.ac.uk/interpro/entry/IPR004215 InterPro IPR004218 http://www.ebi.ac.uk/interpro/entry/IPR004218 InterPro IPR006284 http://www.ebi.ac.uk/interpro/entry/IPR006284 InterPro IPR011761 http://www.ebi.ac.uk/interpro/entry/IPR011761 InterPro IPR013815 http://www.ebi.ac.uk/interpro/entry/IPR013815 InterPro IPR013816 http://www.ebi.ac.uk/interpro/entry/IPR013816 InterPro IPR016185 http://www.ebi.ac.uk/interpro/entry/IPR016185 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2914 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2914 KEGG_Gene eco:b2947 http://www.genome.jp/dbget-bin/www_bget?eco:b2947 KEGG_Orthology KO:K01920 http://www.genome.jp/dbget-bin/www_bget?KO:K01920 KEGG_Pathway ko00480 http://www.genome.jp/kegg-bin/show_pathway?ko00480 KEGG_Reaction rn:R00497 http://www.genome.jp/dbget-bin/www_bget?rn:R00497 OMA GMGIFRV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GMGIFRV PDB 1GLV http://www.ebi.ac.uk/pdbe-srv/view/entry/1GLV PDB 1GSA http://www.ebi.ac.uk/pdbe-srv/view/entry/1GSA PDB 1GSH http://www.ebi.ac.uk/pdbe-srv/view/entry/1GSH PDB 2GLT http://www.ebi.ac.uk/pdbe-srv/view/entry/2GLT PDBsum 1GLV http://www.ebi.ac.uk/pdbsum/1GLV PDBsum 1GSA http://www.ebi.ac.uk/pdbsum/1GSA PDBsum 1GSH http://www.ebi.ac.uk/pdbsum/1GSH PDBsum 2GLT http://www.ebi.ac.uk/pdbsum/2GLT PROSITE PS50975 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50975 PSORT swissprot:GSHB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GSHB_ECOLI PSORT-B swissprot:GSHB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GSHB_ECOLI PSORT2 swissprot:GSHB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GSHB_ECOLI Pfam PF02951 http://pfam.xfam.org/family/PF02951 Pfam PF02955 http://pfam.xfam.org/family/PF02955 Phobius swissprot:GSHB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GSHB_ECOLI PhylomeDB P04425 http://phylomedb.org/?seqid=P04425 ProteinModelPortal P04425 http://www.proteinmodelportal.org/query/uniprot/P04425 PubMed 1540581 http://www.ncbi.nlm.nih.gov/pubmed/1540581 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3042775 http://www.ncbi.nlm.nih.gov/pubmed/3042775 PubMed 6393055 http://www.ncbi.nlm.nih.gov/pubmed/6393055 PubMed 8241129 http://www.ncbi.nlm.nih.gov/pubmed/8241129 PubMed 8445637 http://www.ncbi.nlm.nih.gov/pubmed/8445637 PubMed 9010922 http://www.ncbi.nlm.nih.gov/pubmed/9010922 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417422 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417422 RefSeq WP_000593273 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000593273 SMR P04425 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P04425 STRING 511145.b2947 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2947&targetmode=cogs STRING COG0189 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0189&targetmode=cogs SUPFAM SSF52440 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52440 TIGRFAMs TIGR01380 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01380 UniProtKB GSHB_ECOLI http://www.uniprot.org/uniprot/GSHB_ECOLI UniProtKB-AC P04425 http://www.uniprot.org/uniprot/P04425 charge swissprot:GSHB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GSHB_ECOLI eggNOG COG0189 http://eggnogapi.embl.de/nog_data/html/tree/COG0189 eggNOG ENOG4105D7Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D7Z epestfind swissprot:GSHB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GSHB_ECOLI garnier swissprot:GSHB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GSHB_ECOLI helixturnhelix swissprot:GSHB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GSHB_ECOLI hmoment swissprot:GSHB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GSHB_ECOLI iep swissprot:GSHB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GSHB_ECOLI inforesidue swissprot:GSHB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GSHB_ECOLI octanol swissprot:GSHB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GSHB_ECOLI pepcoil swissprot:GSHB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GSHB_ECOLI pepdigest swissprot:GSHB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GSHB_ECOLI pepinfo swissprot:GSHB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GSHB_ECOLI pepnet swissprot:GSHB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GSHB_ECOLI pepstats swissprot:GSHB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GSHB_ECOLI pepwheel swissprot:GSHB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GSHB_ECOLI pepwindow swissprot:GSHB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GSHB_ECOLI sigcleave swissprot:GSHB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GSHB_ECOLI ## Database ID URL or Descriptions # AltName SSTT_ECOLI Na(+)/serine-threonine symporter # BIOPHYSICOCHEMICAL PROPERTIES SSTT_ECOLI Kinetic parameters KM=0.82 uM for serine {ECO 0000269|PubMed 12097162}; Vmax=0.37 umol/min/mg enzyme {ECO 0000269|PubMed 12097162}; pH dependence Optimum pH is 7.0. {ECO 0000269|PubMed 12097162}; Temperature dependence Optimum temperature is 40 degrees Celsius. {ECO 0000269|PubMed 12097162}; # BioGrid 4260951 7 # ENZYME REGULATION Activated by valinomycin and inhibited by monensin. {ECO:0000269|PubMed 12097162}. # EcoGene EG12732 sstT # FUNCTION SSTT_ECOLI Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system). {ECO 0000269|PubMed 12097162, ECO 0000269|PubMed 9852024}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IDA:EcoliWiki. # GO_function GO:0015175 neutral amino acid transmembrane transporter activity; IDA:EcoliWiki. # GO_function SSTT_ECOLI GO 0005295 neutral amino acid sodium symporter activity; IDA EcoliWiki. # GO_process GO:0006865 amino acid transport; IDA:EcoliWiki. # GO_process GO:0015826 threonine transport; IEA:InterPro. # GO_process GO:0032329 serine transport; IDA:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # Gene3D 1.10.3860.10 -; 1. # HAMAP MF_01582 Ser_Thr_transp_SstT # INDUCTION Repressed by tryptophan. {ECO:0000269|PubMed 9852024}. # InterPro IPR001991 Na-dicarboxylate_symporter # InterPro IPR023025 Ser_Thr_transp_SstT # Organism SSTT_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11958 PTHR11958 # PATRIC 32121596 VBIEscCol129921_3184 # PIR F65097 F65097 # PRINTS PR00173 EDTRNSPORT # PROSITE PS00713 NA_DICARBOXYL_SYMP_1 # Pfam PF00375 SDF # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SSTT_ECOLI Serine/threonine transporter SstT # RefSeq NP_417560 NC_000913.3 # RefSeq WP_000211655 NZ_LN832404.1 # SIMILARITY Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. {ECO 0000305}. # SUBCELLULAR LOCATION SSTT_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF118215 SSF118215 # TCDB 2.A.23.4:the dicarboxylate/amino acid cation (na(+) or h(+)) symporter (daacs) family # eggNOG COG3633 LUCA # eggNOG ENOG4107QV7 Bacteria BLAST swissprot:SSTT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SSTT_ECOLI BioCyc ECOL316407:JW3060-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3060-MONOMER BioCyc EcoCyc:YGJU-MONOMER http://biocyc.org/getid?id=EcoCyc:YGJU-MONOMER BioCyc MetaCyc:YGJU-MONOMER http://biocyc.org/getid?id=MetaCyc:YGJU-MONOMER COG COG3633 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3633 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/oxfordjournals.jbchem.a003201 http://dx.doi.org/10.1093/oxfordjournals.jbchem.a003201 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D13328 http://www.ebi.ac.uk/ena/data/view/D13328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2590 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2590 EcoGene EG12732 http://www.ecogene.org/geneInfo.php?eg_id=EG12732 EnsemblBacteria AAC76124 http://www.ensemblgenomes.org/id/AAC76124 EnsemblBacteria AAC76124 http://www.ensemblgenomes.org/id/AAC76124 EnsemblBacteria BAE77139 http://www.ensemblgenomes.org/id/BAE77139 EnsemblBacteria BAE77139 http://www.ensemblgenomes.org/id/BAE77139 EnsemblBacteria BAE77139 http://www.ensemblgenomes.org/id/BAE77139 EnsemblBacteria b3089 http://www.ensemblgenomes.org/id/b3089 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005295 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005295 GO_function GO:0015175 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015175 GO_process GO:0006865 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865 GO_process GO:0015826 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015826 GO_process GO:0032329 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032329 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 1.10.3860.10 http://www.cathdb.info/version/latest/superfamily/1.10.3860.10 GeneID 947605 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947605 HAMAP MF_01582 http://hamap.expasy.org/unirule/MF_01582 HOGENOM HOG000218252 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218252&db=HOGENOM6 InParanoid P0AGE4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGE4 InterPro IPR001991 http://www.ebi.ac.uk/interpro/entry/IPR001991 InterPro IPR023025 http://www.ebi.ac.uk/interpro/entry/IPR023025 KEGG_Gene ecj:JW3060 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3060 KEGG_Gene eco:b3089 http://www.genome.jp/dbget-bin/www_bget?eco:b3089 KEGG_Orthology KO:K07862 http://www.genome.jp/dbget-bin/www_bget?KO:K07862 OMA MYQRIGL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MYQRIGL PANTHER PTHR11958 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11958 PRINTS PR00173 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00173 PROSITE PS00713 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00713 PSORT swissprot:SSTT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SSTT_ECOLI PSORT-B swissprot:SSTT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SSTT_ECOLI PSORT2 swissprot:SSTT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SSTT_ECOLI Pfam PF00375 http://pfam.xfam.org/family/PF00375 Phobius swissprot:SSTT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SSTT_ECOLI PhylomeDB P0AGE4 http://phylomedb.org/?seqid=P0AGE4 ProteinModelPortal P0AGE4 http://www.proteinmodelportal.org/query/uniprot/P0AGE4 PubMed 12097162 http://www.ncbi.nlm.nih.gov/pubmed/12097162 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9852024 http://www.ncbi.nlm.nih.gov/pubmed/9852024 RefSeq NP_417560 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417560 RefSeq WP_000211655 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000211655 STRING 511145.b3089 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3089&targetmode=cogs STRING COG3633 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3633&targetmode=cogs SUPFAM SSF118215 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF118215 TCDB 2.A.23.4 http://www.tcdb.org/search/result.php?tc=2.A.23.4 UniProtKB SSTT_ECOLI http://www.uniprot.org/uniprot/SSTT_ECOLI UniProtKB-AC P0AGE4 http://www.uniprot.org/uniprot/P0AGE4 charge swissprot:SSTT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SSTT_ECOLI eggNOG COG3633 http://eggnogapi.embl.de/nog_data/html/tree/COG3633 eggNOG ENOG4107QV7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QV7 epestfind swissprot:SSTT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SSTT_ECOLI garnier swissprot:SSTT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SSTT_ECOLI helixturnhelix swissprot:SSTT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SSTT_ECOLI hmoment swissprot:SSTT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SSTT_ECOLI iep swissprot:SSTT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SSTT_ECOLI inforesidue swissprot:SSTT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SSTT_ECOLI octanol swissprot:SSTT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SSTT_ECOLI pepcoil swissprot:SSTT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SSTT_ECOLI pepdigest swissprot:SSTT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SSTT_ECOLI pepinfo swissprot:SSTT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SSTT_ECOLI pepnet swissprot:SSTT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SSTT_ECOLI pepstats swissprot:SSTT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SSTT_ECOLI pepwheel swissprot:SSTT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SSTT_ECOLI pepwindow swissprot:SSTT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SSTT_ECOLI sigcleave swissprot:SSTT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SSTT_ECOLI ## Database ID URL or Descriptions # BioGrid 4262472 66 # EcoGene EG11664 slyX # HAMAP MF_00715 SlyX # InterPro IPR007236 SlyX # Organism SLYX_ECOLI Escherichia coli (strain K12) # PATRIC 32122128 VBIEscCol129921_3441 # PIR A49988 A49988 # Pfam PF04102 SlyX # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SLYX_ECOLI Protein SlyX # RefSeq NP_417807 NC_000913.3 # RefSeq WP_001153615 NZ_LN832404.1 # SIMILARITY Belongs to the SlyX family. {ECO 0000305}. # eggNOG COG2900 LUCA # eggNOG ENOG4105VRX Bacteria BLAST swissprot:SLYX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SLYX_ECOLI BioCyc ECOL316407:JW3310-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3310-MONOMER BioCyc EcoCyc:EG11664-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11664-MONOMER COG COG2900 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2900 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L13261 http://www.ebi.ac.uk/ena/data/view/L13261 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB1615 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1615 EcoGene EG11664 http://www.ecogene.org/geneInfo.php?eg_id=EG11664 EnsemblBacteria AAC76373 http://www.ensemblgenomes.org/id/AAC76373 EnsemblBacteria AAC76373 http://www.ensemblgenomes.org/id/AAC76373 EnsemblBacteria BAE77943 http://www.ensemblgenomes.org/id/BAE77943 EnsemblBacteria BAE77943 http://www.ensemblgenomes.org/id/BAE77943 EnsemblBacteria BAE77943 http://www.ensemblgenomes.org/id/BAE77943 EnsemblBacteria b3348 http://www.ensemblgenomes.org/id/b3348 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947849 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947849 HAMAP MF_00715 http://hamap.expasy.org/unirule/MF_00715 HOGENOM HOG000273046 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000273046&db=HOGENOM6 InParanoid P0A8R4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8R4 InterPro IPR007236 http://www.ebi.ac.uk/interpro/entry/IPR007236 KEGG_Gene ecj:JW3310 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3310 KEGG_Gene eco:b3348 http://www.genome.jp/dbget-bin/www_bget?eco:b3348 KEGG_Orthology KO:K03745 http://www.genome.jp/dbget-bin/www_bget?KO:K03745 OMA DMQPSNI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DMQPSNI PSORT swissprot:SLYX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SLYX_ECOLI PSORT-B swissprot:SLYX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SLYX_ECOLI PSORT2 swissprot:SLYX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SLYX_ECOLI Pfam PF04102 http://pfam.xfam.org/family/PF04102 Phobius swissprot:SLYX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SLYX_ECOLI ProteinModelPortal P0A8R4 http://www.proteinmodelportal.org/query/uniprot/P0A8R4 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8300625 http://www.ncbi.nlm.nih.gov/pubmed/8300625 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417807 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417807 RefSeq WP_001153615 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001153615 SMR P0A8R4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8R4 STRING 511145.b3348 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3348&targetmode=cogs STRING COG2900 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2900&targetmode=cogs UniProtKB SLYX_ECOLI http://www.uniprot.org/uniprot/SLYX_ECOLI UniProtKB-AC P0A8R4 http://www.uniprot.org/uniprot/P0A8R4 charge swissprot:SLYX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SLYX_ECOLI eggNOG COG2900 http://eggnogapi.embl.de/nog_data/html/tree/COG2900 eggNOG ENOG4105VRX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VRX epestfind swissprot:SLYX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SLYX_ECOLI garnier swissprot:SLYX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SLYX_ECOLI helixturnhelix swissprot:SLYX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SLYX_ECOLI hmoment swissprot:SLYX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SLYX_ECOLI iep swissprot:SLYX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SLYX_ECOLI inforesidue swissprot:SLYX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SLYX_ECOLI octanol swissprot:SLYX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SLYX_ECOLI pepcoil swissprot:SLYX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SLYX_ECOLI pepdigest swissprot:SLYX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SLYX_ECOLI pepinfo swissprot:SLYX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SLYX_ECOLI pepnet swissprot:SLYX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SLYX_ECOLI pepstats swissprot:SLYX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SLYX_ECOLI pepwheel swissprot:SLYX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SLYX_ECOLI pepwindow swissprot:SLYX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SLYX_ECOLI sigcleave swissprot:SLYX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SLYX_ECOLI ## Database ID URL or Descriptions # BioGrid 4262615 4 # EcoGene EG11465 yigG # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR020332 Uncharacterised_IM_YigG # Organism YIGG_ECOLI Escherichia coli (strain K12) # PATRIC 32123137 VBIEscCol129921_3934 # PIR S30708 S30708 # ProDom PD084423 Inner_membrane_protein_YigG # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIGG_ECOLI Inner membrane protein YigG # RefSeq NP_418262 NC_000913.3 # RefSeq WP_000944218 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA67614.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAD15040.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SUBCELLULAR LOCATION YIGG_ECOLI Cell inner membrane {ECO 0000269|PubMed 11867724}; Multi-pass membrane protein {ECO 0000269|PubMed 11867724}. # eggNOG ENOG4106WR8 Bacteria # eggNOG ENOG410YS6D LUCA BLAST swissprot:YIGG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIGG_ECOLI BioCyc ECOL316407:JW5590-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5590-MONOMER BioCyc EcoCyc:EG11465-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11465-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.052018199 http://dx.doi.org/10.1073/pnas.052018199 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L02122 http://www.ebi.ac.uk/ena/data/view/L02122 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1433 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1433 EcoGene EG11465 http://www.ecogene.org/geneInfo.php?eg_id=EG11465 EnsemblBacteria AAC76821 http://www.ensemblgenomes.org/id/AAC76821 EnsemblBacteria AAC76821 http://www.ensemblgenomes.org/id/AAC76821 EnsemblBacteria BAE77483 http://www.ensemblgenomes.org/id/BAE77483 EnsemblBacteria BAE77483 http://www.ensemblgenomes.org/id/BAE77483 EnsemblBacteria BAE77483 http://www.ensemblgenomes.org/id/BAE77483 EnsemblBacteria b3818 http://www.ensemblgenomes.org/id/b3818 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 948344 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948344 HOGENOM HOG000050889 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000050889&db=HOGENOM6 InterPro IPR020332 http://www.ebi.ac.uk/interpro/entry/IPR020332 KEGG_Gene ecj:JW5590 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5590 KEGG_Gene eco:b3818 http://www.genome.jp/dbget-bin/www_bget?eco:b3818 OMA EHFDCSG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EHFDCSG PSORT swissprot:YIGG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIGG_ECOLI PSORT-B swissprot:YIGG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIGG_ECOLI PSORT2 swissprot:YIGG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIGG_ECOLI Phobius swissprot:YIGG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIGG_ECOLI ProteinModelPortal P27843 http://www.proteinmodelportal.org/query/uniprot/P27843 PubMed 11867724 http://www.ncbi.nlm.nih.gov/pubmed/11867724 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418262 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418262 RefSeq WP_000944218 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000944218 STRING 511145.b3818 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3818&targetmode=cogs UniProtKB YIGG_ECOLI http://www.uniprot.org/uniprot/YIGG_ECOLI UniProtKB-AC P27843 http://www.uniprot.org/uniprot/P27843 charge swissprot:YIGG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIGG_ECOLI eggNOG ENOG4106WR8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106WR8 eggNOG ENOG410YS6D http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YS6D epestfind swissprot:YIGG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIGG_ECOLI garnier swissprot:YIGG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIGG_ECOLI helixturnhelix swissprot:YIGG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIGG_ECOLI hmoment swissprot:YIGG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIGG_ECOLI iep swissprot:YIGG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIGG_ECOLI inforesidue swissprot:YIGG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIGG_ECOLI octanol swissprot:YIGG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIGG_ECOLI pepcoil swissprot:YIGG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIGG_ECOLI pepdigest swissprot:YIGG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIGG_ECOLI pepinfo swissprot:YIGG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIGG_ECOLI pepnet swissprot:YIGG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIGG_ECOLI pepstats swissprot:YIGG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIGG_ECOLI pepwheel swissprot:YIGG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIGG_ECOLI pepwindow swissprot:YIGG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIGG_ECOLI sigcleave swissprot:YIGG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIGG_ECOLI ## Database ID URL or Descriptions # AltName NUOL_ECOLI NADH dehydrogenase I subunit L # AltName NUOL_ECOLI NDH-1 subunit L # AltName NUOL_ECOLI NUO12 # BioGrid 4260888 12 # CATALYTIC ACTIVITY NUOL_ECOLI NADH + a quinone = NAD(+) + a quinol. # EcoGene EG12092 nuoL # FUNCTION NUOL_ECOLI NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0030964 NADH dehydrogenase complex; IDA:EcoliWiki. # GO_component GO:0045272 plasma membrane respiratory chain complex I; IDA:EcoCyc. # GO_function GO:0008137 NADH dehydrogenase (ubiquinone) activity; IEA:InterPro. # GO_function GO:0048038 quinone binding; IEA:UniProtKB-KW. # GO_process GO:0015990 electron transport coupled proton transport; IMP:EcoCyc. # GO_process GO:0042773 ATP synthesis coupled electron transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0055085 transmembrane transport # InterPro IPR001516 Proton_antipo_N # InterPro IPR001750 ND/Mrp_mem # InterPro IPR003945 NADHpl_OxRdtase_5 # InterPro IPR018393 NADHpl_OxRdtase_5_subgr # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00190 Oxidative phosphorylation # KEGG_Pathway ko00910 Nitrogen metabolism # Organism NUOL_ECOLI Escherichia coli (strain K12) # PATRIC 32119923 VBIEscCol129921_2371 # PIR D64999 D64999 # PRINTS PR01435 NPOXDRDTASE5 # Pfam PF00361 Proton_antipo_M # Pfam PF00662 Proton_antipo_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NUOL_ECOLI NADH-quinone oxidoreductase subunit L # RefSeq NP_416781 NC_000913.3 # RefSeq WP_001056643 NZ_LN832404.1 # SIMILARITY Belongs to the complex I subunit 5 family. {ECO 0000305}. # SUBCELLULAR LOCATION NUOL_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT NUOL_ECOLI Composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex. # TCDB 3.D.1.1 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family # TIGRFAMs TIGR01974 NDH_I_L # eggNOG COG1009 LUCA # eggNOG ENOG4105D65 Bacteria BLAST swissprot:NUOL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NUOL_ECOLI BioCyc ECOL316407:JW2273-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2273-MONOMER BioCyc EcoCyc:NUOL-MONOMER http://biocyc.org/getid?id=EcoCyc:NUOL-MONOMER BioCyc MetaCyc:NUOL-MONOMER http://biocyc.org/getid?id=MetaCyc:NUOL-MONOMER COG COG1009 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1009 DIP DIP-10388N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10388N DOI 10.1006/jmbi.1993.1488 http://dx.doi.org/10.1006/jmbi.1993.1488 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.6.5.11 http://www.genome.jp/dbget-bin/www_bget?EC:1.6.5.11 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X68301 http://www.ebi.ac.uk/ena/data/view/X68301 ENZYME 1.6.5.11 http://enzyme.expasy.org/EC/1.6.5.11 EchoBASE EB2016 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2016 EcoGene EG12092 http://www.ecogene.org/geneInfo.php?eg_id=EG12092 EnsemblBacteria AAC75338 http://www.ensemblgenomes.org/id/AAC75338 EnsemblBacteria AAC75338 http://www.ensemblgenomes.org/id/AAC75338 EnsemblBacteria BAA16106 http://www.ensemblgenomes.org/id/BAA16106 EnsemblBacteria BAA16106 http://www.ensemblgenomes.org/id/BAA16106 EnsemblBacteria BAA16106 http://www.ensemblgenomes.org/id/BAA16106 EnsemblBacteria b2278 http://www.ensemblgenomes.org/id/b2278 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0030964 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030964 GO_component GO:0045272 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045272 GO_function GO:0008137 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008137 GO_function GO:0048038 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048038 GO_process GO:0015990 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015990 GO_process GO:0042773 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042773 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 945540 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945540 HOGENOM HOG000100570 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000100570&db=HOGENOM6 InParanoid P33607 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33607 IntEnz 1.6.5.11 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.6.5.11 InterPro IPR001516 http://www.ebi.ac.uk/interpro/entry/IPR001516 InterPro IPR001750 http://www.ebi.ac.uk/interpro/entry/IPR001750 InterPro IPR003945 http://www.ebi.ac.uk/interpro/entry/IPR003945 InterPro IPR018393 http://www.ebi.ac.uk/interpro/entry/IPR018393 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2273 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2273 KEGG_Gene eco:b2278 http://www.genome.jp/dbget-bin/www_bget?eco:b2278 KEGG_Orthology KO:K00341 http://www.genome.jp/dbget-bin/www_bget?KO:K00341 KEGG_Pathway ko00190 http://www.genome.jp/kegg-bin/show_pathway?ko00190 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Reaction rn:R02166 http://www.genome.jp/dbget-bin/www_bget?rn:R02166 OMA AWEGAIF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AWEGAIF PRINTS PR01435 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01435 PSORT swissprot:NUOL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NUOL_ECOLI PSORT-B swissprot:NUOL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NUOL_ECOLI PSORT2 swissprot:NUOL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NUOL_ECOLI Pfam PF00361 http://pfam.xfam.org/family/PF00361 Pfam PF00662 http://pfam.xfam.org/family/PF00662 Phobius swissprot:NUOL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NUOL_ECOLI PhylomeDB P33607 http://phylomedb.org/?seqid=P33607 ProteinModelPortal P33607 http://www.proteinmodelportal.org/query/uniprot/P33607 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7690854 http://www.ncbi.nlm.nih.gov/pubmed/7690854 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416781 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416781 RefSeq WP_001056643 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001056643 STRING 511145.b2278 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2278&targetmode=cogs STRING COG1009 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1009&targetmode=cogs TCDB 3.D.1.1 http://www.tcdb.org/search/result.php?tc=3.D.1.1 TIGRFAMs TIGR01974 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01974 UniProtKB NUOL_ECOLI http://www.uniprot.org/uniprot/NUOL_ECOLI UniProtKB-AC P33607 http://www.uniprot.org/uniprot/P33607 charge swissprot:NUOL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NUOL_ECOLI eggNOG COG1009 http://eggnogapi.embl.de/nog_data/html/tree/COG1009 eggNOG ENOG4105D65 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D65 epestfind swissprot:NUOL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NUOL_ECOLI garnier swissprot:NUOL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NUOL_ECOLI helixturnhelix swissprot:NUOL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NUOL_ECOLI hmoment swissprot:NUOL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NUOL_ECOLI iep swissprot:NUOL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NUOL_ECOLI inforesidue swissprot:NUOL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NUOL_ECOLI octanol swissprot:NUOL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NUOL_ECOLI pepcoil swissprot:NUOL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NUOL_ECOLI pepdigest swissprot:NUOL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NUOL_ECOLI pepinfo swissprot:NUOL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NUOL_ECOLI pepnet swissprot:NUOL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NUOL_ECOLI pepstats swissprot:NUOL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NUOL_ECOLI pepwheel swissprot:NUOL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NUOL_ECOLI pepwindow swissprot:NUOL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NUOL_ECOLI sigcleave swissprot:NUOL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NUOL_ECOLI ## Database ID URL or Descriptions # BioGrid 4261995 13 # DISRUPTION PHENOTYPE Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain. {ECO:0000269|PubMed 20345943}. # EcoGene EG12773 yraH # FUNCTION YRAH_ECOLI Part of the yraHIJK fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim operon. {ECO 0000269|PubMed 20345943}. # GO_component GO:0009289 pilus; IEA:UniProtKB-SubCell. # GO_process GO:0007155 cell adhesion; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0007155 cell adhesion # Gene3D 2.60.40.1090 -; 1. # INDUCTION Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression. {ECO:0000269|PubMed 20345943}. # InterPro IPR000259 Adhesion_dom_fimbrial # InterPro IPR008966 Adhesion_dom # MISCELLANEOUS The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed. {ECO:0000305|PubMed 20345943}. # Organism YRAH_ECOLI Escherichia coli (strain K12) # PATRIC 32121702 VBIEscCol129921_3237 # PIR B65104 B65104 # Pfam PF00419 Fimbrial # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YRAH_ECOLI Uncharacterized fimbrial-like protein YraH # RefSeq NP_417611 NC_000913.3 # RefSeq WP_001045432 NZ_LN832404.1 # SIMILARITY Belongs to the fimbrial protein family. {ECO 0000305}. # SUBCELLULAR LOCATION YRAH_ECOLI Fimbrium {ECO 0000305}. # SUPFAM SSF49401 SSF49401 # eggNOG ENOG4105Q10 Bacteria # eggNOG ENOG4111VA0 LUCA BLAST swissprot:YRAH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YRAH_ECOLI BioCyc ECOL316407:JW3111-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3111-MONOMER BioCyc EcoCyc:G7637-MONOMER http://biocyc.org/getid?id=EcoCyc:G7637-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1462-2920.2010.02202.x http://dx.doi.org/10.1111/j.1462-2920.2010.02202.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2626 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2626 EcoGene EG12773 http://www.ecogene.org/geneInfo.php?eg_id=EG12773 EnsemblBacteria AAC76176 http://www.ensemblgenomes.org/id/AAC76176 EnsemblBacteria AAC76176 http://www.ensemblgenomes.org/id/AAC76176 EnsemblBacteria BAE77188 http://www.ensemblgenomes.org/id/BAE77188 EnsemblBacteria BAE77188 http://www.ensemblgenomes.org/id/BAE77188 EnsemblBacteria BAE77188 http://www.ensemblgenomes.org/id/BAE77188 EnsemblBacteria b3142 http://www.ensemblgenomes.org/id/b3142 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009289 GO_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 Gene3D 2.60.40.1090 http://www.cathdb.info/version/latest/superfamily/2.60.40.1090 GeneID 947658 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947658 HOGENOM HOG000260127 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260127&db=HOGENOM6 InterPro IPR000259 http://www.ebi.ac.uk/interpro/entry/IPR000259 InterPro IPR008966 http://www.ebi.ac.uk/interpro/entry/IPR008966 KEGG_Gene ecj:JW3111 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3111 KEGG_Gene eco:b3142 http://www.genome.jp/dbget-bin/www_bget?eco:b3142 OMA MKINGLP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MKINGLP PSORT swissprot:YRAH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YRAH_ECOLI PSORT-B swissprot:YRAH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YRAH_ECOLI PSORT2 swissprot:YRAH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YRAH_ECOLI Pfam PF00419 http://pfam.xfam.org/family/PF00419 Phobius swissprot:YRAH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YRAH_ECOLI PhylomeDB P42913 http://phylomedb.org/?seqid=P42913 ProteinModelPortal P42913 http://www.proteinmodelportal.org/query/uniprot/P42913 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20345943 http://www.ncbi.nlm.nih.gov/pubmed/20345943 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417611 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417611 RefSeq WP_001045432 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001045432 STRING 511145.b3142 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3142&targetmode=cogs SUPFAM SSF49401 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49401 UniProtKB YRAH_ECOLI http://www.uniprot.org/uniprot/YRAH_ECOLI UniProtKB-AC P42913 http://www.uniprot.org/uniprot/P42913 charge swissprot:YRAH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YRAH_ECOLI eggNOG ENOG4105Q10 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105Q10 eggNOG ENOG4111VA0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111VA0 epestfind swissprot:YRAH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YRAH_ECOLI garnier swissprot:YRAH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YRAH_ECOLI helixturnhelix swissprot:YRAH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YRAH_ECOLI hmoment swissprot:YRAH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YRAH_ECOLI iep swissprot:YRAH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YRAH_ECOLI inforesidue swissprot:YRAH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YRAH_ECOLI octanol swissprot:YRAH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YRAH_ECOLI pepcoil swissprot:YRAH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YRAH_ECOLI pepdigest swissprot:YRAH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YRAH_ECOLI pepinfo swissprot:YRAH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YRAH_ECOLI pepnet swissprot:YRAH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YRAH_ECOLI pepstats swissprot:YRAH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YRAH_ECOLI pepwheel swissprot:YRAH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YRAH_ECOLI pepwindow swissprot:YRAH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YRAH_ECOLI sigcleave swissprot:YRAH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YRAH_ECOLI ## Database ID URL or Descriptions # BioGrid 4261795 3 # EcoGene EG12794 yhbY # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003723 RNA binding; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # Gene3D 3.30.110.60 -; 1. # IntAct P0AGK4 39 # InterPro IPR001890 RNA-binding_CRM # InterPro IPR017924 RNA-binding_YhbY # KEGG_Brite ko03009 Ribosome biogenesis # Organism YHBY_ECOLI Escherichia coli (strain K12) # PATRIC 32121778 VBIEscCol129921_3273 # PDB 1LN4 X-ray; 1.50 A; A=3-97 # PIR F65108 F65108 # PROSITE PS51295 CRM # Pfam PF01985 CRS1_YhbY # ProDom PD010559 RNA-binding_CRM # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHBY_ECOLI RNA-binding protein YhbY # RefSeq NP_417647 NC_000913.3 # RefSeq WP_001054420 NZ_LN832404.1 # SIMILARITY Contains 1 CRM domain. {ECO:0000255|PROSITE- ProRule PRU00626}. # SMART SM01103 CRS1_YhbY # SUBCELLULAR LOCATION YHBY_ECOLI Cytoplasm {ECO 0000269|PubMed 16980477}. Note=Has been seen to comigrate with the 50S ribosomal subunit in sucrose gradients. # SUPFAM SSF75471 SSF75471 # TIGRFAMs TIGR00253 RNA_bind_YhbY # eggNOG COG1534 LUCA # eggNOG ENOG4105HBR Bacteria BLAST swissprot:YHBY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHBY_ECOLI BioCyc ECOL316407:JW3147-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3147-MONOMER BioCyc EcoCyc:EG12794-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12794-MONOMER COG COG1534 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1534 DIP DIP-47893N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47893N DOI 10.1016/S0969-2126(02)00886-9 http://dx.doi.org/10.1016/S0969-2126(02)00886-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/18.21.6443 http://dx.doi.org/10.1093/nar/18.21.6443 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00444-06 http://dx.doi.org/10.1128/JB.00444-06 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U01376 http://www.ebi.ac.uk/ena/data/view/U01376 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X54718 http://www.ebi.ac.uk/ena/data/view/X54718 EchoBASE EB2646 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2646 EcoGene EG12794 http://www.ecogene.org/geneInfo.php?eg_id=EG12794 EnsemblBacteria AAC76212 http://www.ensemblgenomes.org/id/AAC76212 EnsemblBacteria AAC76212 http://www.ensemblgenomes.org/id/AAC76212 EnsemblBacteria BAE77224 http://www.ensemblgenomes.org/id/BAE77224 EnsemblBacteria BAE77224 http://www.ensemblgenomes.org/id/BAE77224 EnsemblBacteria BAE77224 http://www.ensemblgenomes.org/id/BAE77224 EnsemblBacteria b3180 http://www.ensemblgenomes.org/id/b3180 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 Gene3D 3.30.110.60 http://www.cathdb.info/version/latest/superfamily/3.30.110.60 GeneID 947688 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947688 HOGENOM HOG000016279 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000016279&db=HOGENOM6 InParanoid P0AGK4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGK4 IntAct P0AGK4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AGK4* InterPro IPR001890 http://www.ebi.ac.uk/interpro/entry/IPR001890 InterPro IPR017924 http://www.ebi.ac.uk/interpro/entry/IPR017924 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW3147 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3147 KEGG_Gene eco:b3180 http://www.genome.jp/dbget-bin/www_bget?eco:b3180 KEGG_Orthology KO:K07574 http://www.genome.jp/dbget-bin/www_bget?KO:K07574 MINT MINT-1224994 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1224994 OMA LSPIFQV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LSPIFQV PDB 1LN4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1LN4 PDBsum 1LN4 http://www.ebi.ac.uk/pdbsum/1LN4 PROSITE PS51295 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51295 PSORT swissprot:YHBY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHBY_ECOLI PSORT-B swissprot:YHBY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHBY_ECOLI PSORT2 swissprot:YHBY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHBY_ECOLI Pfam PF01985 http://pfam.xfam.org/family/PF01985 Phobius swissprot:YHBY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHBY_ECOLI PhylomeDB P0AGK4 http://phylomedb.org/?seqid=P0AGK4 ProteinModelPortal P0AGK4 http://www.proteinmodelportal.org/query/uniprot/P0AGK4 PubMed 12429100 http://www.ncbi.nlm.nih.gov/pubmed/12429100 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16980477 http://www.ncbi.nlm.nih.gov/pubmed/16980477 PubMed 2243801 http://www.ncbi.nlm.nih.gov/pubmed/2243801 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417647 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417647 RefSeq WP_001054420 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001054420 SMART SM01103 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01103 SMR P0AGK4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AGK4 STRING 511145.b3180 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3180&targetmode=cogs STRING COG1534 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1534&targetmode=cogs SUPFAM SSF75471 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF75471 TIGRFAMs TIGR00253 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00253 UniProtKB YHBY_ECOLI http://www.uniprot.org/uniprot/YHBY_ECOLI UniProtKB-AC P0AGK4 http://www.uniprot.org/uniprot/P0AGK4 charge swissprot:YHBY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHBY_ECOLI eggNOG COG1534 http://eggnogapi.embl.de/nog_data/html/tree/COG1534 eggNOG ENOG4105HBR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105HBR epestfind swissprot:YHBY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHBY_ECOLI garnier swissprot:YHBY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHBY_ECOLI helixturnhelix swissprot:YHBY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHBY_ECOLI hmoment swissprot:YHBY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHBY_ECOLI iep swissprot:YHBY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHBY_ECOLI inforesidue swissprot:YHBY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHBY_ECOLI octanol swissprot:YHBY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHBY_ECOLI pepcoil swissprot:YHBY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHBY_ECOLI pepdigest swissprot:YHBY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHBY_ECOLI pepinfo swissprot:YHBY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHBY_ECOLI pepnet swissprot:YHBY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHBY_ECOLI pepstats swissprot:YHBY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHBY_ECOLI pepwheel swissprot:YHBY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHBY_ECOLI pepwindow swissprot:YHBY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHBY_ECOLI sigcleave swissprot:YHBY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHBY_ECOLI ## Database ID URL or Descriptions # BioGrid 4262213 171 # CDD cd06174 MFS # EcoGene EG11720 mdtL # FUNCTION MDTL_ECOLI Confers resistance to chloramphenicol. {ECO 0000269|PubMed 11566977}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005215 transporter activity; IEA:UniProtKB-HAMAP. # GO_process GO:0006855 drug transmembrane transport; IMP:EcoCyc. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0008150 biological_process # GOslim_process GO:0055085 transmembrane transport # HAMAP MF_01530 MFS_MdtL # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # InterPro IPR023697 Multidrug-R_MdtL # KEGG_Brite ko02000 Transporters # Organism MDTL_ECOLI Escherichia coli (strain K12) # PATRIC 32122915 VBIEscCol129921_3833 # PIR G65173 G65173 # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MDTL_ECOLI Multidrug resistance protein MdtL # RefSeq NP_418166 NC_000913.3 # RefSeq WP_000085982 NZ_LN832404.1 # SIMILARITY Belongs to the major facilitator superfamily. DHA1 family. MdtL (TC 2.A.1.2.22) subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION MDTL_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.2.22 the major facilitator superfamily (mfs) # eggNOG ENOG4105CNH Bacteria # eggNOG ENOG410YI0P LUCA BLAST swissprot:MDTL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MDTL_ECOLI BioCyc ECOL316407:JW3688-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3688-MONOMER BioCyc EcoCyc:YIDY-MONOMER http://biocyc.org/getid?id=EcoCyc:YIDY-MONOMER COG COG0477 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0477 DIP DIP-12457N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12457N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.183.20.5803-5812.2001 http://dx.doi.org/10.1128/JB.183.20.5803-5812.2001 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1671 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1671 EcoGene EG11720 http://www.ecogene.org/geneInfo.php?eg_id=EG11720 EnsemblBacteria AAC76733 http://www.ensemblgenomes.org/id/AAC76733 EnsemblBacteria AAC76733 http://www.ensemblgenomes.org/id/AAC76733 EnsemblBacteria BAE77580 http://www.ensemblgenomes.org/id/BAE77580 EnsemblBacteria BAE77580 http://www.ensemblgenomes.org/id/BAE77580 EnsemblBacteria BAE77580 http://www.ensemblgenomes.org/id/BAE77580 EnsemblBacteria b3710 http://www.ensemblgenomes.org/id/b3710 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_process GO:0006855 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006855 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 948219 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948219 HAMAP MF_01530 http://hamap.expasy.org/unirule/MF_01530 HOGENOM HOG000277663 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000277663&db=HOGENOM6 InParanoid P31462 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31462 IntAct P31462 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31462* InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 InterPro IPR023697 http://www.ebi.ac.uk/interpro/entry/IPR023697 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3688 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3688 KEGG_Gene eco:b3710 http://www.genome.jp/dbget-bin/www_bget?eco:b3710 KEGG_Orthology KO:K08163 http://www.genome.jp/dbget-bin/www_bget?KO:K08163 MINT MINT-1316334 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1316334 OMA SAVGFFY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SAVGFFY PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:MDTL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MDTL_ECOLI PSORT-B swissprot:MDTL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MDTL_ECOLI PSORT2 swissprot:MDTL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MDTL_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:MDTL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MDTL_ECOLI PhylomeDB P31462 http://phylomedb.org/?seqid=P31462 ProteinModelPortal P31462 http://www.proteinmodelportal.org/query/uniprot/P31462 PubMed 11566977 http://www.ncbi.nlm.nih.gov/pubmed/11566977 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418166 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418166 RefSeq WP_000085982 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000085982 STRING 511145.b3710 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3710&targetmode=cogs STRING COG0477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0477&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.2.22 http://www.tcdb.org/search/result.php?tc=2.A.1.2.22 UniProtKB MDTL_ECOLI http://www.uniprot.org/uniprot/MDTL_ECOLI UniProtKB-AC P31462 http://www.uniprot.org/uniprot/P31462 charge swissprot:MDTL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MDTL_ECOLI eggNOG ENOG4105CNH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CNH eggNOG ENOG410YI0P http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YI0P epestfind swissprot:MDTL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MDTL_ECOLI garnier swissprot:MDTL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MDTL_ECOLI helixturnhelix swissprot:MDTL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MDTL_ECOLI hmoment swissprot:MDTL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MDTL_ECOLI iep swissprot:MDTL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MDTL_ECOLI inforesidue swissprot:MDTL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MDTL_ECOLI octanol swissprot:MDTL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MDTL_ECOLI pepcoil swissprot:MDTL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MDTL_ECOLI pepdigest swissprot:MDTL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MDTL_ECOLI pepinfo swissprot:MDTL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MDTL_ECOLI pepnet swissprot:MDTL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MDTL_ECOLI pepstats swissprot:MDTL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MDTL_ECOLI pepwheel swissprot:MDTL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MDTL_ECOLI pepwindow swissprot:MDTL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MDTL_ECOLI sigcleave swissprot:MDTL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MDTL_ECOLI ## Database ID URL or Descriptions # BioGrid 4263208 7 # CDD cd06261 TM_PBP2 # EcoGene EG10197 cysU # FUNCTION CYST_ECOLI Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015419 ATPase-coupled sulfate transmembrane transporter activity; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # Gene3D 1.10.3720.10 -; 1. # InterPro IPR000515 MetI-like # InterPro IPR005667 Sulph_transpt2 # InterPro IPR011865 CysT_permease # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00185 Sulfate transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism CYST_ECOLI Escherichia coli (strain K12) # PATRIC 32120233 VBIEscCol129921_2519 # PIR A35402 QRECST # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CYST_ECOLI Sulfate transport system permease protein CysT # RefSeq NP_416919 NC_000913.3 # RefSeq WP_000458406 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION CYST_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00441, ECO 0000269|PubMed 15919996}. # SUBUNIT The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute- binding protein (CysP). {ECO 0000305}. # SUPFAM SSF161098 SSF161098 # TCDB 3.A.1.6 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR00969 3a0106s02 # TIGRFAMs TIGR02139 permease_CysT # eggNOG COG0555 LUCA # eggNOG ENOG4108I5D Bacteria BLAST swissprot:CYST_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CYST_ECOLI BioCyc ECOL316407:JW2417-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2417-MONOMER BioCyc EcoCyc:CYST-MONOMER http://biocyc.org/getid?id=EcoCyc:CYST-MONOMER BioCyc MetaCyc:CYST-MONOMER http://biocyc.org/getid?id=MetaCyc:CYST-MONOMER COG COG0555 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0555 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M32101 http://www.ebi.ac.uk/ena/data/view/M32101 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0194 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0194 EcoGene EG10197 http://www.ecogene.org/geneInfo.php?eg_id=EG10197 EnsemblBacteria AAC75477 http://www.ensemblgenomes.org/id/AAC75477 EnsemblBacteria AAC75477 http://www.ensemblgenomes.org/id/AAC75477 EnsemblBacteria BAA16298 http://www.ensemblgenomes.org/id/BAA16298 EnsemblBacteria BAA16298 http://www.ensemblgenomes.org/id/BAA16298 EnsemblBacteria BAA16298 http://www.ensemblgenomes.org/id/BAA16298 EnsemblBacteria b2424 http://www.ensemblgenomes.org/id/b2424 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015419 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015419 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 946882 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946882 HOGENOM HOG000263698 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000263698&db=HOGENOM6 InParanoid P16701 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P16701 InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 InterPro IPR005667 http://www.ebi.ac.uk/interpro/entry/IPR005667 InterPro IPR011865 http://www.ebi.ac.uk/interpro/entry/IPR011865 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2417 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2417 KEGG_Gene eco:b2424 http://www.genome.jp/dbget-bin/www_bget?eco:b2424 KEGG_Orthology KO:K02046 http://www.genome.jp/dbget-bin/www_bget?KO:K02046 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA SWSRRRY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SWSRRRY PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:CYST_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CYST_ECOLI PSORT-B swissprot:CYST_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CYST_ECOLI PSORT2 swissprot:CYST_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CYST_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Phobius swissprot:CYST_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CYST_ECOLI PhylomeDB P16701 http://phylomedb.org/?seqid=P16701 ProteinModelPortal P16701 http://www.proteinmodelportal.org/query/uniprot/P16701 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2188958 http://www.ncbi.nlm.nih.gov/pubmed/2188958 PubMed 2188959 http://www.ncbi.nlm.nih.gov/pubmed/2188959 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416919 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416919 RefSeq WP_000458406 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000458406 STRING 511145.b2424 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2424&targetmode=cogs STRING COG0555 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0555&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.6 http://www.tcdb.org/search/result.php?tc=3.A.1.6 TIGRFAMs TIGR00969 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00969 TIGRFAMs TIGR02139 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02139 UniProtKB CYST_ECOLI http://www.uniprot.org/uniprot/CYST_ECOLI UniProtKB-AC P16701 http://www.uniprot.org/uniprot/P16701 charge swissprot:CYST_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CYST_ECOLI eggNOG COG0555 http://eggnogapi.embl.de/nog_data/html/tree/COG0555 eggNOG ENOG4108I5D http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108I5D epestfind swissprot:CYST_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CYST_ECOLI garnier swissprot:CYST_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CYST_ECOLI helixturnhelix swissprot:CYST_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CYST_ECOLI hmoment swissprot:CYST_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CYST_ECOLI iep swissprot:CYST_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CYST_ECOLI inforesidue swissprot:CYST_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CYST_ECOLI octanol swissprot:CYST_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CYST_ECOLI pepcoil swissprot:CYST_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CYST_ECOLI pepdigest swissprot:CYST_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CYST_ECOLI pepinfo swissprot:CYST_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CYST_ECOLI pepnet swissprot:CYST_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CYST_ECOLI pepstats swissprot:CYST_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CYST_ECOLI pepwheel swissprot:CYST_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CYST_ECOLI pepwindow swissprot:CYST_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CYST_ECOLI sigcleave swissprot:CYST_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CYST_ECOLI ## Database ID URL or Descriptions # AltName AcrAB-TolC multidrug efflux pump accessory protein AcrZ {ECO:0000255|HAMAP-Rule MF_01484} # AltName Acridine resistance protein Z {ECO:0000255|HAMAP-Rule MF_01484} # BioGrid 4259947 12 # DISRUPTION PHENOTYPE Becomes sensitive to some antibiotics (chloramphenicol, puromycin and tetracycline) but not to others (erythromycin, rifampicin and fusidic acid). {ECO:0000269|PubMed 23010927}. # EcoGene EG14328 acrZ # FUNCTION ACRZ_ECOLI AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export. {ECO 0000255|HAMAP-Rule MF_01484, ECO 0000269|PubMed 23010927}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015238 drug transmembrane transporter activity; IMP:UniProtKB. # GO_process GO:0036460 cellular response to cell envelope stress; IMP:EcoCyc. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # HAMAP MF_01484 AcrZ # INDUCTION ACRZ_ECOLI Constitutively expressed (PubMed 19121005), may be repressed at 45 degrees Celsius (PubMed 19121005) (at protein level). Positively regulated by MarA, Rob and SoxS transcriptional regulators. {ECO 0000269|PubMed 19121005, ECO 0000269|PubMed 19734316, ECO 0000269|PubMed 23010927}. # INTERACTION ACRZ_ECOLI P31224 acrB; NbExp=4; IntAct=EBI-6313593, EBI-551006; # IntAct P0AAW9 2 # InterPro IPR019702 AcrZ # Organism ACRZ_ECOLI Escherichia coli (strain K12) # PATRIC 32116725 VBIEscCol129921_0788 # PDB 4C48 X-ray; 3.30 A; C=1-49 # PIR B64812 B64812 # Pfam PF10766 AcrZ # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Multidrug efflux pump accessory protein AcrZ {ECO:0000255|HAMAP-Rule MF_01484} # RefSeq NP_415283 NC_000913.3 # RefSeq WP_000891515 NZ_LN832404.1 # SIMILARITY Belongs to the AcrZ family. {ECO:0000255|HAMAP- Rule MF_01484}. # SUBCELLULAR LOCATION ACRZ_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01484, ECO 0000269|PubMed 19121005, ECO 0000269|PubMed 21778229}; Single-pass membrane protein {ECO 0000255|HAMAP-Rule MF_01484, ECO 0000269|PubMed 19121005, ECO 0000269|PubMed 21778229}. Note=In sucrose cushions fractionates with both the inner and outer membranes. # SUBUNIT ACRZ_ECOLI Part of the AcrA-AcrB-AcrZ-TolC efflux pump, interacts directly with AcrB. {ECO 0000255|HAMAP-Rule MF_01484, ECO 0000269|PubMed 23010927}. # TCDB 2.A.6.2 the resistance-nodulation-cell division (rnd) superfamily # TCDB 8.A.50.1 the acrz rnd auxillary subunit (acrz) family BLAST swissprot:ACRZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ACRZ_ECOLI BioCyc ECOL316407:JW5102-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5102-MONOMER BioCyc EcoCyc:G6396-MONOMER http://biocyc.org/getid?id=EcoCyc:G6396-MONOMER DIP DIP-11423N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11423N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.1210093109 http://dx.doi.org/10.1073/pnas.1210093109 DOI 10.1074/jbc.M111.245696 http://dx.doi.org/10.1074/jbc.M111.245696 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.2008.06495.x http://dx.doi.org/10.1111/j.1365-2958.2008.06495.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00872-09 http://dx.doi.org/10.1128/JB.00872-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4074 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4074 EcoGene EG14328 http://www.ecogene.org/geneInfo.php?eg_id=EG14328 EnsemblBacteria AAC73849 http://www.ensemblgenomes.org/id/AAC73849 EnsemblBacteria AAC73849 http://www.ensemblgenomes.org/id/AAC73849 EnsemblBacteria BAA35426 http://www.ensemblgenomes.org/id/BAA35426 EnsemblBacteria BAA35426 http://www.ensemblgenomes.org/id/BAA35426 EnsemblBacteria BAA35426 http://www.ensemblgenomes.org/id/BAA35426 EnsemblBacteria b0762 http://www.ensemblgenomes.org/id/b0762 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015238 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015238 GO_process GO:0036460 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036460 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 945365 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945365 HAMAP MF_01484 http://hamap.expasy.org/unirule/MF_01484 HOGENOM HOG000219534 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219534&db=HOGENOM6 IntAct P0AAW9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAW9* InterPro IPR019702 http://www.ebi.ac.uk/interpro/entry/IPR019702 KEGG_Gene ecj:JW5102 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5102 KEGG_Gene eco:b0762 http://www.genome.jp/dbget-bin/www_bget?eco:b0762 PDB 4C48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4C48 PDBsum 4C48 http://www.ebi.ac.uk/pdbsum/4C48 PSORT swissprot:ACRZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ACRZ_ECOLI PSORT-B swissprot:ACRZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ACRZ_ECOLI PSORT2 swissprot:ACRZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ACRZ_ECOLI Pfam PF10766 http://pfam.xfam.org/family/PF10766 Phobius swissprot:ACRZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ACRZ_ECOLI ProteinModelPortal P0AAW9 http://www.proteinmodelportal.org/query/uniprot/P0AAW9 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19121005 http://www.ncbi.nlm.nih.gov/pubmed/19121005 PubMed 19734316 http://www.ncbi.nlm.nih.gov/pubmed/19734316 PubMed 21778229 http://www.ncbi.nlm.nih.gov/pubmed/21778229 PubMed 23010927 http://www.ncbi.nlm.nih.gov/pubmed/23010927 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415283 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415283 RefSeq WP_000891515 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000891515 SMR P0AAW9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAW9 STRING 511145.b0762 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0762&targetmode=cogs TCDB 2.A.6.2 http://www.tcdb.org/search/result.php?tc=2.A.6.2 TCDB 8.A.50.1 http://www.tcdb.org/search/result.php?tc=8.A.50.1 UniProtKB ACRZ_ECOLI http://www.uniprot.org/uniprot/ACRZ_ECOLI UniProtKB-AC P0AAW9 http://www.uniprot.org/uniprot/P0AAW9 charge swissprot:ACRZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ACRZ_ECOLI epestfind swissprot:ACRZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ACRZ_ECOLI garnier swissprot:ACRZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ACRZ_ECOLI helixturnhelix swissprot:ACRZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ACRZ_ECOLI hmoment swissprot:ACRZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ACRZ_ECOLI iep swissprot:ACRZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ACRZ_ECOLI inforesidue swissprot:ACRZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ACRZ_ECOLI octanol swissprot:ACRZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ACRZ_ECOLI pepcoil swissprot:ACRZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ACRZ_ECOLI pepdigest swissprot:ACRZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ACRZ_ECOLI pepinfo swissprot:ACRZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ACRZ_ECOLI pepnet swissprot:ACRZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ACRZ_ECOLI pepstats swissprot:ACRZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ACRZ_ECOLI pepwheel swissprot:ACRZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ACRZ_ECOLI pepwindow swissprot:ACRZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ACRZ_ECOLI sigcleave swissprot:ACRZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ACRZ_ECOLI ## Database ID URL or Descriptions # BioGrid 4259453 197 # EcoGene EG11010 tolQ # FUNCTION TOLQ_ECOLI Involved in the TonB-independent uptake of group A colicins (colicins A, E1, E2, E3, and K). # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IDA:EcoliWiki. # GO_component GO:0030313 cell envelope; IDA:EcoCyc. # GO_component GO:0032153 cell division site; IDA:EcoCyc. # GO_function GO:0008565 protein transporter activity; IEA:InterPro. # GO_process GO:0017038 protein import; IMP:EcoliWiki. # GO_process GO:0043213 bacteriocin transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0008565 protein transporter activity # GOslim_process GO:0006810 transport # InterPro IPR002898 MotA_ExbB_proton_chnl # InterPro IPR014163 Tol-Pal_TolQ # KEGG_Brite ko02000 Transporters # Organism TOLQ_ECOLI Escherichia coli (strain K12) # PATRIC 32116673 VBIEscCol129921_0769 # PIR B25980 BVECTQ # Pfam PF01618 MotA_ExbB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TOLQ_ECOLI Protein TolQ # RefSeq NP_415265 NC_000913.3 # SIMILARITY Belongs to the ExbB/TolQ family. {ECO 0000305}. # SUBCELLULAR LOCATION TOLQ_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 1.A.30.2 the h(+)- or na(+)-translocating bacterial flagellar motor/exbbd outer membrane transport energizer (mot/exb) superfamily # TIGRFAMs TIGR02796 tolQ # eggNOG COG0811 LUCA # eggNOG ENOG4105E02 Bacteria BLAST swissprot:TOLQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TOLQ_ECOLI BioCyc ECOL316407:JW0727-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0727-MONOMER BioCyc EcoCyc:EG11010-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11010-MONOMER COG COG0811 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0811 DIP DIP-11008N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11008N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M16489 http://www.ebi.ac.uk/ena/data/view/M16489 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1003 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1003 EcoGene EG11010 http://www.ecogene.org/geneInfo.php?eg_id=EG11010 EnsemblBacteria AAC73831 http://www.ensemblgenomes.org/id/AAC73831 EnsemblBacteria AAC73831 http://www.ensemblgenomes.org/id/AAC73831 EnsemblBacteria BAA35403 http://www.ensemblgenomes.org/id/BAA35403 EnsemblBacteria BAA35403 http://www.ensemblgenomes.org/id/BAA35403 EnsemblBacteria BAA35403 http://www.ensemblgenomes.org/id/BAA35403 EnsemblBacteria b0737 http://www.ensemblgenomes.org/id/b0737 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0030313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030313 GO_component GO:0032153 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032153 GO_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GO_process GO:0017038 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017038 GO_process GO:0043213 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043213 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948900 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948900 HOGENOM HOG000134795 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000134795&db=HOGENOM6 InParanoid P0ABU9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABU9 InterPro IPR002898 http://www.ebi.ac.uk/interpro/entry/IPR002898 InterPro IPR014163 http://www.ebi.ac.uk/interpro/entry/IPR014163 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0727 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0727 KEGG_Gene eco:b0737 http://www.genome.jp/dbget-bin/www_bget?eco:b0737 KEGG_Orthology KO:K03562 http://www.genome.jp/dbget-bin/www_bget?KO:K03562 OMA LESHLPF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LESHLPF PSORT swissprot:TOLQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TOLQ_ECOLI PSORT-B swissprot:TOLQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TOLQ_ECOLI PSORT2 swissprot:TOLQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TOLQ_ECOLI Pfam PF01618 http://pfam.xfam.org/family/PF01618 Phobius swissprot:TOLQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TOLQ_ECOLI PhylomeDB P0ABU9 http://phylomedb.org/?seqid=P0ABU9 ProteinModelPortal P0ABU9 http://www.proteinmodelportal.org/query/uniprot/P0ABU9 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3294803 http://www.ncbi.nlm.nih.gov/pubmed/3294803 PubMed 8300535 http://www.ncbi.nlm.nih.gov/pubmed/8300535 PubMed 8331075 http://www.ncbi.nlm.nih.gov/pubmed/8331075 PubMed 8376353 http://www.ncbi.nlm.nih.gov/pubmed/8376353 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415265 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415265 STRING 511145.b0737 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0737&targetmode=cogs STRING COG0811 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0811&targetmode=cogs TCDB 1.A.30.2 http://www.tcdb.org/search/result.php?tc=1.A.30.2 TIGRFAMs TIGR02796 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02796 UniProtKB TOLQ_ECOLI http://www.uniprot.org/uniprot/TOLQ_ECOLI UniProtKB-AC P0ABU9 http://www.uniprot.org/uniprot/P0ABU9 charge swissprot:TOLQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TOLQ_ECOLI eggNOG COG0811 http://eggnogapi.embl.de/nog_data/html/tree/COG0811 eggNOG ENOG4105E02 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E02 epestfind swissprot:TOLQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TOLQ_ECOLI garnier swissprot:TOLQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TOLQ_ECOLI helixturnhelix swissprot:TOLQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TOLQ_ECOLI hmoment swissprot:TOLQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TOLQ_ECOLI iep swissprot:TOLQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TOLQ_ECOLI inforesidue swissprot:TOLQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TOLQ_ECOLI octanol swissprot:TOLQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TOLQ_ECOLI pepcoil swissprot:TOLQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TOLQ_ECOLI pepdigest swissprot:TOLQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TOLQ_ECOLI pepinfo swissprot:TOLQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TOLQ_ECOLI pepnet swissprot:TOLQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TOLQ_ECOLI pepstats swissprot:TOLQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TOLQ_ECOLI pepwheel swissprot:TOLQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TOLQ_ECOLI pepwindow swissprot:TOLQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TOLQ_ECOLI sigcleave swissprot:TOLQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TOLQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4261387 11 # CDD cd06174 MFS # EcoGene EG13454 hcaT # FUNCTION HCAT_ECOLI Probable permease involved in the uptake of 3- phenylpropionic acid. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015293 symporter activity; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # InterPro IPR020846 MFS_dom # InterPro IPR024989 MFS_assoc_dom # InterPro IPR026032 HcaT # KEGG_Brite ko02000 Transporters # Organism HCAT_ECOLI Escherichia coli (strain K12) # PATRIC 32120469 VBIEscCol129921_2637 # PIR G65030 G65030 # PIR S49295 S49295 # PIRSF PIRSF004925 HcaT # Pfam PF12832 MFS_1_like # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HCAT_ECOLI Probable 3-phenylpropionic acid transporter # RefSeq NP_417031 NC_000913.3 # RefSeq WP_000244193 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA86021.1; Type=Frameshift; Positions=208; Evidence={ECO 0000305}; # SIMILARITY Belongs to the LacY/RafB permease family. HcaT subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION HCAT_ECOLI Cell inner membrane {ECO 0000305}; Multi- pass membrane protein {ECO 0000305}. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.27 the major facilitator superfamily (mfs) # TIGRFAMs TIGR00902 2A0127 # eggNOG ENOG4105D8G Bacteria # eggNOG ENOG410XQVS LUCA BLAST swissprot:HCAT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HCAT_ECOLI BioCyc ECOL316407:JW2520-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2520-MONOMER BioCyc EcoCyc:HCAT-MONOMER http://biocyc.org/getid?id=EcoCyc:HCAT-MONOMER COG COG0477 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0477 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL Y11071 http://www.ebi.ac.uk/ena/data/view/Y11071 EMBL Z37966 http://www.ebi.ac.uk/ena/data/view/Z37966 EchoBASE EB3227 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3227 EcoGene EG13454 http://www.ecogene.org/geneInfo.php?eg_id=EG13454 EnsemblBacteria AAC75589 http://www.ensemblgenomes.org/id/AAC75589 EnsemblBacteria AAC75589 http://www.ensemblgenomes.org/id/AAC75589 EnsemblBacteria BAA16431 http://www.ensemblgenomes.org/id/BAA16431 EnsemblBacteria BAA16431 http://www.ensemblgenomes.org/id/BAA16431 EnsemblBacteria BAA16431 http://www.ensemblgenomes.org/id/BAA16431 EnsemblBacteria b2536 http://www.ensemblgenomes.org/id/b2536 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015293 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GeneID 947007 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947007 HOGENOM HOG000272903 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000272903&db=HOGENOM6 InParanoid Q47142 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q47142 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 InterPro IPR024989 http://www.ebi.ac.uk/interpro/entry/IPR024989 InterPro IPR026032 http://www.ebi.ac.uk/interpro/entry/IPR026032 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2520 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2520 KEGG_Gene eco:b2536 http://www.genome.jp/dbget-bin/www_bget?eco:b2536 KEGG_Orthology KO:K05820 http://www.genome.jp/dbget-bin/www_bget?KO:K05820 OMA MDYGRVR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MDYGRVR PSORT swissprot:HCAT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HCAT_ECOLI PSORT-B swissprot:HCAT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HCAT_ECOLI PSORT2 swissprot:HCAT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HCAT_ECOLI Pfam PF12832 http://pfam.xfam.org/family/PF12832 Phobius swissprot:HCAT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HCAT_ECOLI PhylomeDB Q47142 http://phylomedb.org/?seqid=Q47142 ProteinModelPortal Q47142 http://www.proteinmodelportal.org/query/uniprot/Q47142 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9603882 http://www.ncbi.nlm.nih.gov/pubmed/9603882 RefSeq NP_417031 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417031 RefSeq WP_000244193 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000244193 STRING 511145.b2536 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2536&targetmode=cogs STRING COG0477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0477&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.27 http://www.tcdb.org/search/result.php?tc=2.A.1.27 TIGRFAMs TIGR00902 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00902 UniProtKB HCAT_ECOLI http://www.uniprot.org/uniprot/HCAT_ECOLI UniProtKB-AC Q47142 http://www.uniprot.org/uniprot/Q47142 charge swissprot:HCAT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HCAT_ECOLI eggNOG ENOG4105D8G http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D8G eggNOG ENOG410XQVS http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQVS epestfind swissprot:HCAT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HCAT_ECOLI garnier swissprot:HCAT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HCAT_ECOLI helixturnhelix swissprot:HCAT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HCAT_ECOLI hmoment swissprot:HCAT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HCAT_ECOLI iep swissprot:HCAT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HCAT_ECOLI inforesidue swissprot:HCAT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HCAT_ECOLI octanol swissprot:HCAT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HCAT_ECOLI pepcoil swissprot:HCAT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HCAT_ECOLI pepdigest swissprot:HCAT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HCAT_ECOLI pepinfo swissprot:HCAT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HCAT_ECOLI pepnet swissprot:HCAT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HCAT_ECOLI pepstats swissprot:HCAT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HCAT_ECOLI pepwheel swissprot:HCAT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HCAT_ECOLI pepwindow swissprot:HCAT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HCAT_ECOLI sigcleave swissprot:HCAT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HCAT_ECOLI ## Database ID URL or Descriptions # BioGrid 4260976 6 # CDD cd00429 RPE # COFACTOR SGCE_ECOLI Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000250}; Name=Fe(2+); Xref=ChEBI CHEBI 29033; Evidence={ECO 0000250}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000250}; Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000250}; Note=Binds 1 divalent metal cation per subunit. Active with Co(2+), Fe(2+), Mn(2+) and Zn(2+). {ECO 0000250}; # EcoGene EG12553 sgcE # FUNCTION SGCE_ECOLI Probable pentose-5-phosphate 3-epimerase. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0004750 ribulose-phosphate 3-epimerase activity; IBA:GO_Central. # GO_function GO:0046872 metal ion binding; IBA:GO_Central. # GO_process GO:0009052 pentose-phosphate shunt, non-oxidative branch; IBA:GO_Central. # GO_process GO:0019323 pentose catabolic process; IBA:GO_Central. # GO_process GO:0044262 cellular carbohydrate metabolic process; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.70 -; 1. # IntAct P39362 5 # InterPro IPR000056 Ribul_P_3_epim-like # InterPro IPR011060 RibuloseP-bd_barrel # InterPro IPR013785 Aldolase_TIM # KEGG_Brite ko01000 Enzymes # Organism SGCE_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11749 PTHR11749 # PATRIC 32124188 VBIEscCol129921_4437 # PIR S56526 S56526 # PROSITE PS01085 RIBUL_P_3_EPIMER_1 # PROSITE PS01086 RIBUL_P_3_EPIMER_2 # Pfam PF00834 Ribul_P_3_epim # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SGCE_ECOLI Protein SgcE # RefSeq NP_418721 NC_000913.3 # RefSeq WP_000600622 NZ_LN832404.1 # SIMILARITY Belongs to the ribulose-phosphate 3-epimerase family. {ECO 0000305}. # SUPFAM SSF51366 SSF51366 # eggNOG COG0036 LUCA # eggNOG ENOG4108RK0 Bacteria BLAST swissprot:SGCE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SGCE_ECOLI BioCyc ECOL316407:JW4263-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4263-MONOMER BioCyc EcoCyc:G7914-MONOMER http://biocyc.org/getid?id=EcoCyc:G7914-MONOMER COG COG0036 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0036 DIP DIP-10878N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10878N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.1.3.- http://www.genome.jp/dbget-bin/www_bget?EC:5.1.3.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 5.1.3.- http://enzyme.expasy.org/EC/5.1.3.- EchoBASE EB2441 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2441 EcoGene EG12553 http://www.ecogene.org/geneInfo.php?eg_id=EG12553 EnsemblBacteria AAC77257 http://www.ensemblgenomes.org/id/AAC77257 EnsemblBacteria AAC77257 http://www.ensemblgenomes.org/id/AAC77257 EnsemblBacteria BAE78292 http://www.ensemblgenomes.org/id/BAE78292 EnsemblBacteria BAE78292 http://www.ensemblgenomes.org/id/BAE78292 EnsemblBacteria BAE78292 http://www.ensemblgenomes.org/id/BAE78292 EnsemblBacteria b4301 http://www.ensemblgenomes.org/id/b4301 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004750 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004750 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0009052 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009052 GO_process GO:0019323 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019323 GO_process GO:0044262 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044262 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 948829 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948829 HOGENOM HOG000259347 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000259347&db=HOGENOM6 InParanoid P39362 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39362 IntAct P39362 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39362* IntEnz 5.1.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.1.3 InterPro IPR000056 http://www.ebi.ac.uk/interpro/entry/IPR000056 InterPro IPR011060 http://www.ebi.ac.uk/interpro/entry/IPR011060 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4263 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4263 KEGG_Gene eco:b4301 http://www.genome.jp/dbget-bin/www_bget?eco:b4301 KEGG_Orthology KO:K14587 http://www.genome.jp/dbget-bin/www_bget?KO:K14587 OMA PYLNDVE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PYLNDVE PANTHER PTHR11749 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11749 PROSITE PS01085 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01085 PROSITE PS01086 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01086 PSORT swissprot:SGCE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SGCE_ECOLI PSORT-B swissprot:SGCE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SGCE_ECOLI PSORT2 swissprot:SGCE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SGCE_ECOLI Pfam PF00834 http://pfam.xfam.org/family/PF00834 Phobius swissprot:SGCE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SGCE_ECOLI PhylomeDB P39362 http://phylomedb.org/?seqid=P39362 ProteinModelPortal P39362 http://www.proteinmodelportal.org/query/uniprot/P39362 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418721 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418721 RefSeq WP_000600622 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000600622 SMR P39362 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39362 STRING 511145.b4301 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4301&targetmode=cogs STRING COG0036 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0036&targetmode=cogs SUPFAM SSF51366 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51366 UniProtKB SGCE_ECOLI http://www.uniprot.org/uniprot/SGCE_ECOLI UniProtKB-AC P39362 http://www.uniprot.org/uniprot/P39362 charge swissprot:SGCE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SGCE_ECOLI eggNOG COG0036 http://eggnogapi.embl.de/nog_data/html/tree/COG0036 eggNOG ENOG4108RK0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108RK0 epestfind swissprot:SGCE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SGCE_ECOLI garnier swissprot:SGCE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SGCE_ECOLI helixturnhelix swissprot:SGCE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SGCE_ECOLI hmoment swissprot:SGCE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SGCE_ECOLI iep swissprot:SGCE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SGCE_ECOLI inforesidue swissprot:SGCE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SGCE_ECOLI octanol swissprot:SGCE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SGCE_ECOLI pepcoil swissprot:SGCE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SGCE_ECOLI pepdigest swissprot:SGCE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SGCE_ECOLI pepinfo swissprot:SGCE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SGCE_ECOLI pepnet swissprot:SGCE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SGCE_ECOLI pepstats swissprot:SGCE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SGCE_ECOLI pepwheel swissprot:SGCE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SGCE_ECOLI pepwindow swissprot:SGCE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SGCE_ECOLI sigcleave swissprot:SGCE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SGCE_ECOLI ## Database ID URL or Descriptions # AltName Dihydroxyacetone kinase subunit M {ECO:0000303|PubMed 11350937} # AltName Lysine deacetylase {ECO:0000303|PubMed 26716769} # AltName PEP-dependent dihydroxyacetone kinase, phosphoryl donor subunit DhaM {ECO:0000305|PubMed 11350937} # BIOPHYSICOCHEMICAL PROPERTIES DHAM_ECOLI Kinetic parameters KM=2.13 uM for acetylated RutR {ECO 0000269|PubMed 26716769}; Vmax=0.29 umol/min/mg enzyme for the deacetylation of RutR {ECO 0000269|PubMed 26716769}; # BRENDA 2.7.1.29 2026 # BioGrid 4260761 17 # CDD cd00367 PTS-HPr_like # COFACTOR Note=Does not use NAD(+) or Zn(2+) like other established KDACs. {ECO:0000269|PubMed 26716769}; # DOMAIN DHAM_ECOLI Consists of three domains. The N-terminal dimerization domain has the same fold as the IIA domain of the mannose transporter of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The middle domain is similar to HPr and the C-terminus is similar to the N-terminal domain of enzyme I (EI) of the PTS. The IIA domain of DhaM (via phospho-His- 9), instead of ATP, is the phosphoryl donor to dihydroxyacetone (Dha). The phosphoryl flow likely involves HPr ('His-15') -> DhaM (His-430 -> His-169 -> His-9) -> DhaL-ADP -> Dha. The HPr-like domain of DhaM cannot efficiently substitute for the general carrier protein HPr. {ECO 0000305|PubMed 11350937}. # EcoGene EG12399 dhaM # FUNCTION DHAM_ECOLI Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaM serves as the phosphoryl donor. Is phosphorylated by phosphoenolpyruvate in an EI- and HPr- dependent reaction, and a phosphorelay system on histidine residues finally leads to phosphoryl transfer to DhaL and dihydroxyacetone. {ECO 0000269|PubMed 11350937}. # FUNCTION DHAM_ECOLI Protein deacetylase that removes acetyl groups on specific lysine residues in target proteins. Regulates transcription by catalyzing deacetylation of 'Lys-52' and 'Lys-62' of the transcriptional repressor RutR. Is also able to deacetylate NhoA and RluC in vitro. Targets a distinct set of substrates compared to CobB. {ECO 0000269|PubMed 26716769}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:InterPro. # GO_function GO:0016772 transferase activity, transferring phosphorus-containing groups; IEA:InterPro. # GO_function GO:0016787 hydrolase activity; IEA:UniProtKB-KW. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:InterPro. # GO_process GO:0016310 phosphorylation; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006810 transport # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # Gene3D 1.10.274.10 -; 1. # Gene3D 3.30.1340.10 -; 1. # Gene3D 3.40.50.510 -; 1. # Gene3D 3.50.30.10 -; 1. # InterPro IPR000032 HPr-like # InterPro IPR001020 PTS_HPr_His_P_site # InterPro IPR004701 PTS_EIIA_man-typ # InterPro IPR008279 PEP-util_enz_mobile_dom # InterPro IPR008731 PTS_EIN # InterPro IPR012844 DhaM_N # KEGG_Brite ko02000 Transporters # MISCELLANEOUS Unlike the carbohydrate-specific transporters of the PTS, the complex DhaKLM has no transport activity. {ECO:0000269|PubMed 11350937}. # Organism DHAM_ECOLI Escherichia coli (strain K12) # PATRIC 32117646 VBIEscCol129921_1245 # PIR C64866 C64866 # PRINTS PR00107 PHOSPHOCPHPR # PROSITE PS00369 PTS_HPR_HIS # PROSITE PS51096 PTS_EIIA_TYPE_4 # PROSITE PS51350 PTS_HPR_DOM # Pfam PF00381 PTS-HPr # Pfam PF00391 PEP-utilizers # Pfam PF03610 EIIA-man # Pfam PF05524 PEP-utilisers_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Protein-lysine deacetylase {ECO:0000303|PubMed 26716769} # RefSeq NP_415716 NC_000913.3 # RefSeq WP_001301101 NZ_LN832404.1 # SIMILARITY Belongs to the PEP-utilizing enzyme family. {ECO 0000305}. # SIMILARITY Contains 1 HPr domain. {ECO:0000255|PROSITE- ProRule PRU00681}. # SIMILARITY Contains 1 PTS EIIA type-4 domain. {ECO:0000255|PROSITE-ProRule PRU00419}. # SUBUNIT Homodimer (PubMed:11350937). The dihydroxyacetone kinase complex is composed of a homodimer of DhaM, a homodimer of DhaK and the subunit DhaL. {ECO 0000269|PubMed:11350937}. # SUPFAM SSF47831 SSF47831 # SUPFAM SSF52009 SSF52009 # SUPFAM SSF53062 SSF53062 # SUPFAM SSF55594 SSF55594 # TIGRFAMs TIGR01003 PTS_HPr_family # TIGRFAMs TIGR02364 dha_pts # eggNOG COG1080 LUCA # eggNOG COG1925 LUCA # eggNOG COG3412 LUCA # eggNOG ENOG4105VDH Bacteria BLAST swissprot:DHAM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DHAM_ECOLI BioCyc ECOL316407:JW5185-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5185-MONOMER BioCyc EcoCyc:EG12399-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12399-MONOMER BioCyc MetaCyc:EG12399-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12399-MONOMER DIP DIP-11551N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11551N DOI 10.1007/BF02464903 http://dx.doi.org/10.1007/BF02464903 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/emboj/20.10.2480 http://dx.doi.org/10.1093/emboj/20.10.2480 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.7554/eLife.05322 http://dx.doi.org/10.7554/eLife.05322 EC_number EC:3.5.1.- {ECO:0000269|PubMed:26716769} http://www.genome.jp/dbget-bin/www_bget?EC:3.5.1.- {ECO:0000269|PubMed:26716769} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X15868 http://www.ebi.ac.uk/ena/data/view/X15868 ENZYME 3.5.1.- {ECO:0000269|PubMed:26716769} http://enzyme.expasy.org/EC/3.5.1.- {ECO:0000269|PubMed:26716769} EchoBASE EB2299 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2299 EcoGene EG12399 http://www.ecogene.org/geneInfo.php?eg_id=EG12399 EnsemblBacteria AAC74282 http://www.ensemblgenomes.org/id/AAC74282 EnsemblBacteria AAC74282 http://www.ensemblgenomes.org/id/AAC74282 EnsemblBacteria BAA36055 http://www.ensemblgenomes.org/id/BAA36055 EnsemblBacteria BAA36055 http://www.ensemblgenomes.org/id/BAA36055 EnsemblBacteria BAA36055 http://www.ensemblgenomes.org/id/BAA36055 EnsemblBacteria b1198 http://www.ensemblgenomes.org/id/b1198 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0016772 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016772 GO_function GO:0016787 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016787 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GO_process GO:0016310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016310 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.10.274.10 http://www.cathdb.info/version/latest/superfamily/1.10.274.10 Gene3D 3.30.1340.10 http://www.cathdb.info/version/latest/superfamily/3.30.1340.10 Gene3D 3.40.50.510 http://www.cathdb.info/version/latest/superfamily/3.40.50.510 Gene3D 3.50.30.10 http://www.cathdb.info/version/latest/superfamily/3.50.30.10 GeneID 945749 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945749 HOGENOM HOG000119746 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000119746&db=HOGENOM6 IntAct P37349 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37349* IntEnz 3.5.1.- {ECO:0000269|PubMed:26716769} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.1.- {ECO:0000269|PubMed:26716769} InterPro IPR000032 http://www.ebi.ac.uk/interpro/entry/IPR000032 InterPro IPR001020 http://www.ebi.ac.uk/interpro/entry/IPR001020 InterPro IPR004701 http://www.ebi.ac.uk/interpro/entry/IPR004701 InterPro IPR008279 http://www.ebi.ac.uk/interpro/entry/IPR008279 InterPro IPR008731 http://www.ebi.ac.uk/interpro/entry/IPR008731 InterPro IPR012844 http://www.ebi.ac.uk/interpro/entry/IPR012844 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5185 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5185 KEGG_Gene eco:b1198 http://www.genome.jp/dbget-bin/www_bget?eco:b1198 KEGG_Orthology KO:K05881 http://www.genome.jp/dbget-bin/www_bget?KO:K05881 OMA TDHVLVM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TDHVLVM PRINTS PR00107 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00107 PROSITE PS00369 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00369 PROSITE PS51096 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51096 PROSITE PS51350 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51350 PSORT swissprot:DHAM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DHAM_ECOLI PSORT-B swissprot:DHAM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DHAM_ECOLI PSORT2 swissprot:DHAM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DHAM_ECOLI Pfam PF00381 http://pfam.xfam.org/family/PF00381 Pfam PF00391 http://pfam.xfam.org/family/PF00391 Pfam PF03610 http://pfam.xfam.org/family/PF03610 Pfam PF05524 http://pfam.xfam.org/family/PF05524 Phobius swissprot:DHAM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DHAM_ECOLI PhylomeDB P37349 http://phylomedb.org/?seqid=P37349 ProteinModelPortal P37349 http://www.proteinmodelportal.org/query/uniprot/P37349 PubMed 11350937 http://www.ncbi.nlm.nih.gov/pubmed/11350937 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2671658 http://www.ncbi.nlm.nih.gov/pubmed/2671658 PubMed 26716769 http://www.ncbi.nlm.nih.gov/pubmed/26716769 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415716 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415716 RefSeq WP_001301101 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001301101 SMR P37349 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37349 STRING 511145.b1198 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1198&targetmode=cogs SUPFAM SSF47831 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47831 SUPFAM SSF52009 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52009 SUPFAM SSF53062 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53062 SUPFAM SSF55594 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55594 SWISS-2DPAGE P37349 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P37349 TIGRFAMs TIGR01003 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01003 TIGRFAMs TIGR02364 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02364 UniProtKB DHAM_ECOLI http://www.uniprot.org/uniprot/DHAM_ECOLI UniProtKB-AC P37349 http://www.uniprot.org/uniprot/P37349 charge swissprot:DHAM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DHAM_ECOLI eggNOG COG1080 http://eggnogapi.embl.de/nog_data/html/tree/COG1080 eggNOG COG1925 http://eggnogapi.embl.de/nog_data/html/tree/COG1925 eggNOG COG3412 http://eggnogapi.embl.de/nog_data/html/tree/COG3412 eggNOG ENOG4105VDH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VDH epestfind swissprot:DHAM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DHAM_ECOLI garnier swissprot:DHAM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DHAM_ECOLI helixturnhelix swissprot:DHAM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DHAM_ECOLI hmoment swissprot:DHAM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DHAM_ECOLI iep swissprot:DHAM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DHAM_ECOLI inforesidue swissprot:DHAM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DHAM_ECOLI octanol swissprot:DHAM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DHAM_ECOLI pepcoil swissprot:DHAM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DHAM_ECOLI pepdigest swissprot:DHAM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DHAM_ECOLI pepinfo swissprot:DHAM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DHAM_ECOLI pepnet swissprot:DHAM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DHAM_ECOLI pepstats swissprot:DHAM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DHAM_ECOLI pepwheel swissprot:DHAM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DHAM_ECOLI pepwindow swissprot:DHAM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DHAM_ECOLI sigcleave swissprot:DHAM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DHAM_ECOLI ## Database ID URL or Descriptions # BioGrid 4261181 18 # EcoGene EG12883 pitB # FUNCTION PITB_ECOLI Low-affinity inorganic phosphate transport. {ECO 0000250}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; ISM:EcoCyc. # GO_component GO:0016021 integral component of membrane; IDA:EcoCyc. # GO_function GO:0005315 inorganic phosphate transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0035435 phosphate ion transmembrane transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0055085 transmembrane transport # InterPro IPR001204 Phos_transporter # KEGG_Brite ko02000 Transporters # Organism PITB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11101 PTHR11101 # PATRIC 32121390 VBIEscCol129921_3082 # PIR A65085 A65085 # Pfam PF01384 PHO4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PITB_ECOLI Probable low-affinity inorganic phosphate transporter 2 # RefSeq NP_417461 NC_000913.3 # RefSeq WP_000933250 NZ_LN832404.1 # SIMILARITY Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. Pit subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION PITB_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # TCDB 2.A.20.1 the inorganic phosphate transporter (pit) family # eggNOG COG0306 LUCA # eggNOG ENOG4105CJ3 Bacteria BLAST swissprot:PITB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PITB_ECOLI BioCyc ECOL316407:JW2955-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2955-MONOMER BioCyc EcoCyc:PITB-MONOMER http://biocyc.org/getid?id=EcoCyc:PITB-MONOMER BioCyc MetaCyc:PITB-MONOMER http://biocyc.org/getid?id=MetaCyc:PITB-MONOMER COG COG0306 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0306 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.270.23.14031 http://dx.doi.org/10.1074/jbc.270.23.14031 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U23148 http://www.ebi.ac.uk/ena/data/view/U23148 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2721 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2721 EcoGene EG12883 http://www.ecogene.org/geneInfo.php?eg_id=EG12883 EnsemblBacteria AAC76023 http://www.ensemblgenomes.org/id/AAC76023 EnsemblBacteria AAC76023 http://www.ensemblgenomes.org/id/AAC76023 EnsemblBacteria BAE77048 http://www.ensemblgenomes.org/id/BAE77048 EnsemblBacteria BAE77048 http://www.ensemblgenomes.org/id/BAE77048 EnsemblBacteria BAE77048 http://www.ensemblgenomes.org/id/BAE77048 EnsemblBacteria b2987 http://www.ensemblgenomes.org/id/b2987 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005315 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005315 GO_process GO:0035435 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035435 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 947475 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947475 HOGENOM HOG000231893 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231893&db=HOGENOM6 InParanoid P43676 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P43676 InterPro IPR001204 http://www.ebi.ac.uk/interpro/entry/IPR001204 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2955 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2955 KEGG_Gene eco:b2987 http://www.genome.jp/dbget-bin/www_bget?eco:b2987 KEGG_Orthology KO:K16322 http://www.genome.jp/dbget-bin/www_bget?KO:K16322 OMA YGTIWAD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YGTIWAD PANTHER PTHR11101 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11101 PSORT swissprot:PITB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PITB_ECOLI PSORT-B swissprot:PITB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PITB_ECOLI PSORT2 swissprot:PITB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PITB_ECOLI Pfam PF01384 http://pfam.xfam.org/family/PF01384 Phobius swissprot:PITB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PITB_ECOLI PhylomeDB P43676 http://phylomedb.org/?seqid=P43676 ProteinModelPortal P43676 http://www.proteinmodelportal.org/query/uniprot/P43676 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7775463 http://www.ncbi.nlm.nih.gov/pubmed/7775463 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417461 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417461 RefSeq WP_000933250 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000933250 STRING 511145.b2987 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2987&targetmode=cogs STRING COG0306 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0306&targetmode=cogs TCDB 2.A.20.1 http://www.tcdb.org/search/result.php?tc=2.A.20.1 UniProtKB PITB_ECOLI http://www.uniprot.org/uniprot/PITB_ECOLI UniProtKB-AC P43676 http://www.uniprot.org/uniprot/P43676 charge swissprot:PITB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PITB_ECOLI eggNOG COG0306 http://eggnogapi.embl.de/nog_data/html/tree/COG0306 eggNOG ENOG4105CJ3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CJ3 epestfind swissprot:PITB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PITB_ECOLI garnier swissprot:PITB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PITB_ECOLI helixturnhelix swissprot:PITB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PITB_ECOLI hmoment swissprot:PITB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PITB_ECOLI iep swissprot:PITB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PITB_ECOLI inforesidue swissprot:PITB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PITB_ECOLI octanol swissprot:PITB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PITB_ECOLI pepcoil swissprot:PITB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PITB_ECOLI pepdigest swissprot:PITB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PITB_ECOLI pepinfo swissprot:PITB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PITB_ECOLI pepnet swissprot:PITB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PITB_ECOLI pepstats swissprot:PITB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PITB_ECOLI pepwheel swissprot:PITB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PITB_ECOLI pepwindow swissprot:PITB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PITB_ECOLI sigcleave swissprot:PITB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PITB_ECOLI ## Database ID URL or Descriptions # BioGrid 4263365 17 # EcoGene EG14295 ymjA # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # IntAct P0ACV8 12 # InterPro IPR020251 Uncharacterised_YmjA # Organism YMJA_ECOLI Escherichia coli (strain K12) # PATRIC 32117860 VBIEscCol129921_1350 # PIR B64878 B64878 # Pfam PF10820 DUF2543 # ProDom PD059807 Uncharacterized_YmjA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YMJA_ECOLI Uncharacterized protein YmjA # RefSeq NP_415811 NC_000913.3 # RefSeq WP_001015110 NZ_LN832404.1 # eggNOG ENOG4105N0E Bacteria # eggNOG ENOG4111W05 LUCA BLAST swissprot:YMJA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YMJA_ECOLI BioCyc ECOL316407:JW1288-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1288-MONOMER BioCyc EcoCyc:G6642-MONOMER http://biocyc.org/getid?id=EcoCyc:G6642-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4043 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4043 EcoGene EG14295 http://www.ecogene.org/geneInfo.php?eg_id=EG14295 EnsemblBacteria AAC74377 http://www.ensemblgenomes.org/id/AAC74377 EnsemblBacteria AAC74377 http://www.ensemblgenomes.org/id/AAC74377 EnsemblBacteria BAE76397 http://www.ensemblgenomes.org/id/BAE76397 EnsemblBacteria BAE76397 http://www.ensemblgenomes.org/id/BAE76397 EnsemblBacteria BAE76397 http://www.ensemblgenomes.org/id/BAE76397 EnsemblBacteria b1295 http://www.ensemblgenomes.org/id/b1295 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GeneID 945874 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945874 HOGENOM HOG000267965 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267965&db=HOGENOM6 IntAct P0ACV8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACV8* InterPro IPR020251 http://www.ebi.ac.uk/interpro/entry/IPR020251 KEGG_Gene ecj:JW1288 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1288 KEGG_Gene eco:b1295 http://www.genome.jp/dbget-bin/www_bget?eco:b1295 OMA YYDIVDE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YYDIVDE PSORT swissprot:YMJA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YMJA_ECOLI PSORT-B swissprot:YMJA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YMJA_ECOLI PSORT2 swissprot:YMJA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YMJA_ECOLI Pfam PF10820 http://pfam.xfam.org/family/PF10820 Phobius swissprot:YMJA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YMJA_ECOLI ProteinModelPortal P0ACV8 http://www.proteinmodelportal.org/query/uniprot/P0ACV8 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415811 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415811 RefSeq WP_001015110 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001015110 STRING 511145.b1295 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1295&targetmode=cogs UniProtKB YMJA_ECOLI http://www.uniprot.org/uniprot/YMJA_ECOLI UniProtKB-AC P0ACV8 http://www.uniprot.org/uniprot/P0ACV8 charge swissprot:YMJA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YMJA_ECOLI eggNOG ENOG4105N0E http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105N0E eggNOG ENOG4111W05 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111W05 epestfind swissprot:YMJA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YMJA_ECOLI garnier swissprot:YMJA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YMJA_ECOLI helixturnhelix swissprot:YMJA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YMJA_ECOLI hmoment swissprot:YMJA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YMJA_ECOLI iep swissprot:YMJA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YMJA_ECOLI inforesidue swissprot:YMJA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YMJA_ECOLI octanol swissprot:YMJA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YMJA_ECOLI pepcoil swissprot:YMJA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YMJA_ECOLI pepdigest swissprot:YMJA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YMJA_ECOLI pepinfo swissprot:YMJA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YMJA_ECOLI pepnet swissprot:YMJA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YMJA_ECOLI pepstats swissprot:YMJA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YMJA_ECOLI pepwheel swissprot:YMJA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YMJA_ECOLI pepwindow swissprot:YMJA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YMJA_ECOLI sigcleave swissprot:YMJA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YMJA_ECOLI ## Database ID URL or Descriptions # EcoGene EG14370 yrhD # Organism YRHD_ECOLI Escherichia coli (strain K12) # Proteomes UP000000625 Chromosome # RecName YRHD_ECOLI Uncharacterized protein YrhD BLAST swissprot:YRHD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YRHD_ECOLI BioCyc EcoCyc:MONOMER0-2826 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2826 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EcoGene EG14370 http://www.ecogene.org/geneInfo.php?eg_id=EG14370 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv HOGENOM HOG000081231 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000081231&db=HOGENOM6 PSORT swissprot:YRHD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YRHD_ECOLI PSORT-B swissprot:YRHD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YRHD_ECOLI PSORT2 swissprot:YRHD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YRHD_ECOLI Phobius swissprot:YRHD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YRHD_ECOLI ProteinModelPortal P58037 http://www.proteinmodelportal.org/query/uniprot/P58037 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 STRING 511145.b4612 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4612&targetmode=cogs UniProtKB YRHD_ECOLI http://www.uniprot.org/uniprot/YRHD_ECOLI UniProtKB-AC P58037 http://www.uniprot.org/uniprot/P58037 charge swissprot:YRHD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YRHD_ECOLI epestfind swissprot:YRHD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YRHD_ECOLI garnier swissprot:YRHD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YRHD_ECOLI helixturnhelix swissprot:YRHD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YRHD_ECOLI hmoment swissprot:YRHD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YRHD_ECOLI iep swissprot:YRHD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YRHD_ECOLI inforesidue swissprot:YRHD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YRHD_ECOLI octanol swissprot:YRHD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YRHD_ECOLI pepcoil swissprot:YRHD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YRHD_ECOLI pepdigest swissprot:YRHD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YRHD_ECOLI pepinfo swissprot:YRHD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YRHD_ECOLI pepnet swissprot:YRHD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YRHD_ECOLI pepstats swissprot:YRHD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YRHD_ECOLI pepwheel swissprot:YRHD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YRHD_ECOLI pepwindow swissprot:YRHD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YRHD_ECOLI sigcleave swissprot:YRHD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YRHD_ECOLI ## Database ID URL or Descriptions # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG14438 yibV # InterPro IPR028955 Imm57 # Organism YIBV_ECOLI Escherichia coli (strain K12) # Pfam PF15596 Imm57 # Proteomes UP000000625 Chromosome # RecName YIBV_ECOLI Putative uncharacterized protein YibV BLAST swissprot:YIBV_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIBV_ECOLI BioCyc EcoCyc:MONOMER0-2827 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2827 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14438 http://www.ecogene.org/geneInfo.php?eg_id=EG14438 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv HOGENOM HOG000050907 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000050907&db=HOGENOM6 InterPro IPR028955 http://www.ebi.ac.uk/interpro/entry/IPR028955 PSORT swissprot:YIBV_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIBV_ECOLI PSORT-B swissprot:YIBV_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIBV_ECOLI PSORT2 swissprot:YIBV_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIBV_ECOLI Pfam PF15596 http://pfam.xfam.org/family/PF15596 Phobius swissprot:YIBV_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIBV_ECOLI ProteinModelPortal A5A625 http://www.proteinmodelportal.org/query/uniprot/A5A625 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 UniProtKB YIBV_ECOLI http://www.uniprot.org/uniprot/YIBV_ECOLI UniProtKB-AC A5A625 http://www.uniprot.org/uniprot/A5A625 charge swissprot:YIBV_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIBV_ECOLI epestfind swissprot:YIBV_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIBV_ECOLI garnier swissprot:YIBV_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIBV_ECOLI helixturnhelix swissprot:YIBV_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIBV_ECOLI hmoment swissprot:YIBV_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIBV_ECOLI iep swissprot:YIBV_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIBV_ECOLI inforesidue swissprot:YIBV_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIBV_ECOLI octanol swissprot:YIBV_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIBV_ECOLI pepcoil swissprot:YIBV_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIBV_ECOLI pepdigest swissprot:YIBV_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIBV_ECOLI pepinfo swissprot:YIBV_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIBV_ECOLI pepnet swissprot:YIBV_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIBV_ECOLI pepstats swissprot:YIBV_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIBV_ECOLI pepwheel swissprot:YIBV_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIBV_ECOLI pepwindow swissprot:YIBV_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIBV_ECOLI sigcleave swissprot:YIBV_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIBV_ECOLI ## Database ID URL or Descriptions # BioGrid 4262707 207 # EcoGene EG12488 yjfM # IntAct P39295 2 # InterPro IPR009576 Biofilm_formation_YgiB # Organism YJFM_ECOLI Escherichia coli (strain K12) # PATRIC 32123945 VBIEscCol129921_4317 # PIR S56410 S56410 # Pfam PF06693 DUF1190 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJFM_ECOLI Uncharacterized protein YjfM # RefSeq NP_418606 NC_000913.3 # RefSeq WP_000101658 NZ_LN832404.1 # eggNOG COG5463 LUCA # eggNOG ENOG4108KXT Bacteria BLAST swissprot:YJFM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJFM_ECOLI BioCyc ECOL316407:JW4143-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4143-MONOMER BioCyc EcoCyc:G7850-MONOMER http://biocyc.org/getid?id=EcoCyc:G7850-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2381 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2381 EcoGene EG12488 http://www.ecogene.org/geneInfo.php?eg_id=EG12488 EnsemblBacteria AAC77142 http://www.ensemblgenomes.org/id/AAC77142 EnsemblBacteria AAC77142 http://www.ensemblgenomes.org/id/AAC77142 EnsemblBacteria BAE78186 http://www.ensemblgenomes.org/id/BAE78186 EnsemblBacteria BAE78186 http://www.ensemblgenomes.org/id/BAE78186 EnsemblBacteria BAE78186 http://www.ensemblgenomes.org/id/BAE78186 EnsemblBacteria b4185 http://www.ensemblgenomes.org/id/b4185 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 948700 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948700 HOGENOM HOG000127353 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000127353&db=HOGENOM6 IntAct P39295 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39295* InterPro IPR009576 http://www.ebi.ac.uk/interpro/entry/IPR009576 KEGG_Gene ecj:JW4143 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4143 KEGG_Gene eco:b4185 http://www.genome.jp/dbget-bin/www_bget?eco:b4185 OMA ACSTAYG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ACSTAYG PSORT swissprot:YJFM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJFM_ECOLI PSORT-B swissprot:YJFM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJFM_ECOLI PSORT2 swissprot:YJFM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJFM_ECOLI Pfam PF06693 http://pfam.xfam.org/family/PF06693 Phobius swissprot:YJFM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJFM_ECOLI ProteinModelPortal P39295 http://www.proteinmodelportal.org/query/uniprot/P39295 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418606 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418606 RefSeq WP_000101658 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000101658 STRING 511145.b4185 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4185&targetmode=cogs UniProtKB YJFM_ECOLI http://www.uniprot.org/uniprot/YJFM_ECOLI UniProtKB-AC P39295 http://www.uniprot.org/uniprot/P39295 charge swissprot:YJFM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJFM_ECOLI eggNOG COG5463 http://eggnogapi.embl.de/nog_data/html/tree/COG5463 eggNOG ENOG4108KXT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108KXT epestfind swissprot:YJFM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJFM_ECOLI garnier swissprot:YJFM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJFM_ECOLI helixturnhelix swissprot:YJFM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJFM_ECOLI hmoment swissprot:YJFM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJFM_ECOLI iep swissprot:YJFM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJFM_ECOLI inforesidue swissprot:YJFM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJFM_ECOLI octanol swissprot:YJFM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJFM_ECOLI pepcoil swissprot:YJFM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJFM_ECOLI pepdigest swissprot:YJFM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJFM_ECOLI pepinfo swissprot:YJFM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJFM_ECOLI pepnet swissprot:YJFM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJFM_ECOLI pepstats swissprot:YJFM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJFM_ECOLI pepwheel swissprot:YJFM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJFM_ECOLI pepwindow swissprot:YJFM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJFM_ECOLI sigcleave swissprot:YJFM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJFM_ECOLI ## Database ID URL or Descriptions # AltName BGA2_ECOLI Lactase # BioGrid 4263419 6 # CATALYTIC ACTIVITY BGA2_ECOLI Hydrolysis of terminal non-reducing beta-D- galactose residues in beta-D-galactosides. # CAZy GH2 Glycoside Hydrolase Family 2 # DrugBank DB00581 Lactulose # EcoGene EG10252 ebgA # FUNCTION BGA2_ECOLI The wild-type enzyme is an ineffective lactase. Two classes of point mutations dramatically improve activity of the enzyme. # GO_component GO:0009341 beta-galactosidase complex; IEA:InterPro. # GO_component GO:0043231 intracellular membrane-bounded organelle; IBA:GO_Central. # GO_function GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds; IBA:GO_Central. # GO_function GO:0004565 beta-galactosidase activity; IEA:UniProtKB-EC. # GO_function GO:0030246 carbohydrate binding; IEA:InterPro. # GO_process GO:0005975 carbohydrate metabolic process; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043226 organelle # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_process GO:0005975 carbohydrate metabolic process # Gene3D 2.60.120.260 -; 1. # Gene3D 2.60.40.320 -; 2. # Gene3D 2.70.98.10 -; 1. # Gene3D 3.20.20.80 -; 1. # IntAct P06864 6 # InterPro IPR004199 B-gal_small/dom_5 # InterPro IPR006101 Glyco_hydro_2 # InterPro IPR006102 Glyco_hydro_2_Ig-like # InterPro IPR006103 Glyco_hydro_2_cat # InterPro IPR006104 Glyco_hydro_2_N # InterPro IPR008979 Galactose-bd-like # InterPro IPR011013 Gal_mutarotase_SF_dom # InterPro IPR013781 Glyco_hydro_catalytic_dom # InterPro IPR013812 Glyco_hydro_2/20_Ig-like # InterPro IPR014718 GH-type_carb-bd # InterPro IPR017853 Glycoside_hydrolase_SF # InterPro IPR023230 Glyco_hydro_2_CS # InterPro IPR023232 Glyco_hydro_2_AS # InterPro IPR032312 LacZ_4 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00052 Galactose metabolism # KEGG_Pathway ko00511 Other glycan degradation # Organism BGA2_ECOLI Escherichia coli (strain K12) # PATRIC 32121568 VBIEscCol129921_3170 # PIR A65096 GBECE # PRINTS PR00132 GLHYDRLASE2 # PROSITE PS00608 GLYCOSYL_HYDROL_F2_2 # PROSITE PS00719 GLYCOSYL_HYDROL_F2_1 # Pfam PF00703 Glyco_hydro_2 # Pfam PF02836 Glyco_hydro_2_C # Pfam PF02837 Glyco_hydro_2_N # Pfam PF02929 Bgal_small_N # Pfam PF16353 DUF4981 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BGA2_ECOLI Evolved beta-galactosidase subunit alpha # RefSeq WP_001082856 NZ_LN832404.1 # RefSeq YP_026199 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA57877.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the glycosyl hydrolase 2 family. {ECO 0000305}. # SMART SM01038 Bgal_small_N # SUBUNIT Heterooctamer of 4 alpha and 4 beta subunits. {ECO:0000269|PubMed 1540130}. # SUPFAM SSF49303 SSF49303; 2 # SUPFAM SSF49785 SSF49785 # SUPFAM SSF51445 SSF51445 # SUPFAM SSF74650 SSF74650 # eggNOG COG3250 LUCA # eggNOG ENOG4105CNT Bacteria BLAST swissprot:BGA2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BGA2_ECOLI BioCyc ECOL316407:JW5511-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5511-MONOMER BioCyc EcoCyc:EG10252-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10252-MONOMER COG COG3250 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3250 DIP DIP-2893N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-2893N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2820155 http://dx.doi.org/10.1042/bj2820155 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB00581 http://www.drugbank.ca/drugs/DB00581 EC_number EC:3.2.1.23 http://www.genome.jp/dbget-bin/www_bget?EC:3.2.1.23 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M64441 http://www.ebi.ac.uk/ena/data/view/M64441 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X03228 http://www.ebi.ac.uk/ena/data/view/X03228 EMBL X52031 http://www.ebi.ac.uk/ena/data/view/X52031 ENZYME 3.2.1.23 http://enzyme.expasy.org/EC/3.2.1.23 EchoBASE EB0248 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0248 EcoGene EG10252 http://www.ecogene.org/geneInfo.php?eg_id=EG10252 EnsemblBacteria AAT48164 http://www.ensemblgenomes.org/id/AAT48164 EnsemblBacteria AAT48164 http://www.ensemblgenomes.org/id/AAT48164 EnsemblBacteria BAE77126 http://www.ensemblgenomes.org/id/BAE77126 EnsemblBacteria BAE77126 http://www.ensemblgenomes.org/id/BAE77126 EnsemblBacteria BAE77126 http://www.ensemblgenomes.org/id/BAE77126 EnsemblBacteria b3076 http://www.ensemblgenomes.org/id/b3076 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009341 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009341 GO_component GO:0043231 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231 GO_function GO:0004553 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004553 GO_function GO:0004565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004565 GO_function GO:0030246 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030246 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 Gene3D 2.60.120.260 http://www.cathdb.info/version/latest/superfamily/2.60.120.260 Gene3D 2.60.40.320 http://www.cathdb.info/version/latest/superfamily/2.60.40.320 Gene3D 2.70.98.10 http://www.cathdb.info/version/latest/superfamily/2.70.98.10 Gene3D 3.20.20.80 http://www.cathdb.info/version/latest/superfamily/3.20.20.80 GeneID 947583 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947583 HOGENOM HOG000252444 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000252444&db=HOGENOM6 InParanoid P06864 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P06864 IntAct P06864 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P06864* IntEnz 3.2.1.23 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.2.1.23 InterPro IPR004199 http://www.ebi.ac.uk/interpro/entry/IPR004199 InterPro IPR006101 http://www.ebi.ac.uk/interpro/entry/IPR006101 InterPro IPR006102 http://www.ebi.ac.uk/interpro/entry/IPR006102 InterPro IPR006103 http://www.ebi.ac.uk/interpro/entry/IPR006103 InterPro IPR006104 http://www.ebi.ac.uk/interpro/entry/IPR006104 InterPro IPR008979 http://www.ebi.ac.uk/interpro/entry/IPR008979 InterPro IPR011013 http://www.ebi.ac.uk/interpro/entry/IPR011013 InterPro IPR013781 http://www.ebi.ac.uk/interpro/entry/IPR013781 InterPro IPR013812 http://www.ebi.ac.uk/interpro/entry/IPR013812 InterPro IPR014718 http://www.ebi.ac.uk/interpro/entry/IPR014718 InterPro IPR017853 http://www.ebi.ac.uk/interpro/entry/IPR017853 InterPro IPR023230 http://www.ebi.ac.uk/interpro/entry/IPR023230 InterPro IPR023232 http://www.ebi.ac.uk/interpro/entry/IPR023232 InterPro IPR032312 http://www.ebi.ac.uk/interpro/entry/IPR032312 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5511 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5511 KEGG_Gene eco:b3076 http://www.genome.jp/dbget-bin/www_bget?eco:b3076 KEGG_Orthology KO:K12111 http://www.genome.jp/dbget-bin/www_bget?KO:K12111 KEGG_Pathway ko00052 http://www.genome.jp/kegg-bin/show_pathway?ko00052 KEGG_Pathway ko00511 http://www.genome.jp/kegg-bin/show_pathway?ko00511 KEGG_Reaction rn:R01678 http://www.genome.jp/dbget-bin/www_bget?rn:R01678 KEGG_Reaction rn:R06114 http://www.genome.jp/dbget-bin/www_bget?rn:R06114 OMA HGVAIYT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HGVAIYT PRINTS PR00132 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00132 PROSITE PS00608 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00608 PROSITE PS00719 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00719 PSORT swissprot:BGA2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BGA2_ECOLI PSORT-B swissprot:BGA2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BGA2_ECOLI PSORT2 swissprot:BGA2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BGA2_ECOLI Pfam PF00703 http://pfam.xfam.org/family/PF00703 Pfam PF02836 http://pfam.xfam.org/family/PF02836 Pfam PF02837 http://pfam.xfam.org/family/PF02837 Pfam PF02929 http://pfam.xfam.org/family/PF02929 Pfam PF16353 http://pfam.xfam.org/family/PF16353 Phobius swissprot:BGA2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BGA2_ECOLI PhylomeDB P06864 http://phylomedb.org/?seqid=P06864 ProteinModelPortal P06864 http://www.proteinmodelportal.org/query/uniprot/P06864 PubMed 1540130 http://www.ncbi.nlm.nih.gov/pubmed/1540130 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2515108 http://www.ncbi.nlm.nih.gov/pubmed/2515108 PubMed 3939707 http://www.ncbi.nlm.nih.gov/pubmed/3939707 PubMed 6411710 http://www.ncbi.nlm.nih.gov/pubmed/6411710 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001082856 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001082856 RefSeq YP_026199 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026199 SMART SM01038 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01038 SMR P06864 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P06864 STRING 511145.b3076 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3076&targetmode=cogs STRING COG3250 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3250&targetmode=cogs SUPFAM SSF49303 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49303 SUPFAM SSF49785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49785 SUPFAM SSF51445 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51445 SUPFAM SSF74650 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF74650 UniProtKB BGA2_ECOLI http://www.uniprot.org/uniprot/BGA2_ECOLI UniProtKB-AC P06864 http://www.uniprot.org/uniprot/P06864 charge swissprot:BGA2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BGA2_ECOLI eggNOG COG3250 http://eggnogapi.embl.de/nog_data/html/tree/COG3250 eggNOG ENOG4105CNT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CNT epestfind swissprot:BGA2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BGA2_ECOLI garnier swissprot:BGA2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BGA2_ECOLI helixturnhelix swissprot:BGA2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BGA2_ECOLI hmoment swissprot:BGA2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BGA2_ECOLI iep swissprot:BGA2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BGA2_ECOLI inforesidue swissprot:BGA2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BGA2_ECOLI octanol swissprot:BGA2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BGA2_ECOLI pepcoil swissprot:BGA2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BGA2_ECOLI pepdigest swissprot:BGA2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BGA2_ECOLI pepinfo swissprot:BGA2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BGA2_ECOLI pepnet swissprot:BGA2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BGA2_ECOLI pepstats swissprot:BGA2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BGA2_ECOLI pepwheel swissprot:BGA2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BGA2_ECOLI pepwindow swissprot:BGA2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BGA2_ECOLI sigcleave swissprot:BGA2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BGA2_ECOLI ## Database ID URL or Descriptions # AltName HSLO_ECOLI Heat shock protein 33 # BioGrid 4262486 6 # CDD cd00498 Hsp33 # EcoGene EG12930 hslO # FUNCTION HSLO_ECOLI Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IPI:IntAct. # GO_process GO:0006457 protein folding; IEA:InterPro. # GO_process GO:0009408 response to heat; IEP:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006457 protein folding # GOslim_process GO:0006950 response to stress # Gene3D 1.10.287.480 -; 1. # Gene3D 3.55.30.10 -; 1. # Gene3D 3.90.1280.10 -; 1. # HAMAP MF_00117 HslO # INDUCTION HSLO_ECOLI By heat shock. # INTERACTION HSLO_ECOLI Self; NbExp=5; IntAct=EBI-562857, EBI-562857; P0CE47 tufA; NbExp=2; IntAct=EBI-562857, EBI-301077; # IntAct P0A6Y5 10 # InterPro IPR000397 Heat_shock_Hsp33 # InterPro IPR016153 Heat_shock_Hsp33_N # InterPro IPR016154 Heat_shock_Hsp33_C # InterPro IPR023212 Hsp33_helix_hairpin_bin_dom # KEGG_Brite ko03110 Chaperones and folding catalysts # Organism HSLO_ECOLI Escherichia coli (strain K12) # PATRIC 32122236 VBIEscCol129921_3495 # PDB 1HW7 X-ray; 2.20 A; A=1-253 # PDB 1I7F X-ray; 2.70 A; A=1-292 # PDB 1XJH NMR; -; A=225-285 # PDB 3M7M X-ray; 2.90 A; X=1-233 # PIR D65135 D65135 # PIRSF PIRSF005261 Heat_shock_Hsp33 # PTM HSLO_ECOLI Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive. # Pfam PF01430 HSP33 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 33 kDa chaperonin {ECO:0000255|HAMAP-Rule MF_00117} # RefSeq NP_417860 NC_000913.3 # RefSeq WP_001135574 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA58198.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the HSP33 family. {ECO:0000255|HAMAP- Rule MF_00117}. # SUBCELLULAR LOCATION HSLO_ECOLI Cytoplasm. # SUPFAM SSF118352 SSF118352 # SUPFAM SSF64397 SSF64397 # eggNOG COG1281 LUCA # eggNOG ENOG4105F4C Bacteria BLAST swissprot:HSLO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HSLO_ECOLI BioCyc ECOL316407:JW5692-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5692-MONOMER BioCyc EcoCyc:G7744-MONOMER http://biocyc.org/getid?id=EcoCyc:G7744-MONOMER COG COG1281 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1281 DIP DIP-48013N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48013N DOI 10.1016/S0092-8674(00)80547-4 http://dx.doi.org/10.1016/S0092-8674(00)80547-4 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M001089200 http://dx.doi.org/10.1074/jbc.M001089200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2766 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2766 EcoGene EG12930 http://www.ecogene.org/geneInfo.php?eg_id=EG12930 EnsemblBacteria AAC76426 http://www.ensemblgenomes.org/id/AAC76426 EnsemblBacteria AAC76426 http://www.ensemblgenomes.org/id/AAC76426 EnsemblBacteria BAE77890 http://www.ensemblgenomes.org/id/BAE77890 EnsemblBacteria BAE77890 http://www.ensemblgenomes.org/id/BAE77890 EnsemblBacteria BAE77890 http://www.ensemblgenomes.org/id/BAE77890 EnsemblBacteria b3401 http://www.ensemblgenomes.org/id/b3401 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 1.10.287.480 http://www.cathdb.info/version/latest/superfamily/1.10.287.480 Gene3D 3.55.30.10 http://www.cathdb.info/version/latest/superfamily/3.55.30.10 Gene3D 3.90.1280.10 http://www.cathdb.info/version/latest/superfamily/3.90.1280.10 GeneID 947178 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947178 HAMAP MF_00117 http://hamap.expasy.org/unirule/MF_00117 HOGENOM HOG000261998 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261998&db=HOGENOM6 InParanoid P0A6Y5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6Y5 IntAct P0A6Y5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6Y5* InterPro IPR000397 http://www.ebi.ac.uk/interpro/entry/IPR000397 InterPro IPR016153 http://www.ebi.ac.uk/interpro/entry/IPR016153 InterPro IPR016154 http://www.ebi.ac.uk/interpro/entry/IPR016154 InterPro IPR023212 http://www.ebi.ac.uk/interpro/entry/IPR023212 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW5692 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5692 KEGG_Gene eco:b3401 http://www.genome.jp/dbget-bin/www_bget?eco:b3401 KEGG_Orthology KO:K04083 http://www.genome.jp/dbget-bin/www_bget?KO:K04083 MINT MINT-8302273 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8302273 OMA IVCQFCQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IVCQFCQ PDB 1HW7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1HW7 PDB 1I7F http://www.ebi.ac.uk/pdbe-srv/view/entry/1I7F PDB 1XJH http://www.ebi.ac.uk/pdbe-srv/view/entry/1XJH PDB 3M7M http://www.ebi.ac.uk/pdbe-srv/view/entry/3M7M PDBsum 1HW7 http://www.ebi.ac.uk/pdbsum/1HW7 PDBsum 1I7F http://www.ebi.ac.uk/pdbsum/1I7F PDBsum 1XJH http://www.ebi.ac.uk/pdbsum/1XJH PDBsum 3M7M http://www.ebi.ac.uk/pdbsum/3M7M PSORT swissprot:HSLO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HSLO_ECOLI PSORT-B swissprot:HSLO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HSLO_ECOLI PSORT2 swissprot:HSLO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HSLO_ECOLI Pfam PF01430 http://pfam.xfam.org/family/PF01430 Phobius swissprot:HSLO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HSLO_ECOLI PhylomeDB P0A6Y5 http://phylomedb.org/?seqid=P0A6Y5 ProteinModelPortal P0A6Y5 http://www.proteinmodelportal.org/query/uniprot/P0A6Y5 PubMed 10025400 http://www.ncbi.nlm.nih.gov/pubmed/10025400 PubMed 10764757 http://www.ncbi.nlm.nih.gov/pubmed/10764757 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417860 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417860 RefSeq WP_001135574 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001135574 SMR P0A6Y5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6Y5 STRING 511145.b3401 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3401&targetmode=cogs STRING COG1281 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1281&targetmode=cogs SUPFAM SSF118352 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF118352 SUPFAM SSF64397 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF64397 UniProtKB HSLO_ECOLI http://www.uniprot.org/uniprot/HSLO_ECOLI UniProtKB-AC P0A6Y5 http://www.uniprot.org/uniprot/P0A6Y5 charge swissprot:HSLO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HSLO_ECOLI eggNOG COG1281 http://eggnogapi.embl.de/nog_data/html/tree/COG1281 eggNOG ENOG4105F4C http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F4C epestfind swissprot:HSLO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HSLO_ECOLI garnier swissprot:HSLO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HSLO_ECOLI helixturnhelix swissprot:HSLO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HSLO_ECOLI hmoment swissprot:HSLO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HSLO_ECOLI iep swissprot:HSLO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HSLO_ECOLI inforesidue swissprot:HSLO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HSLO_ECOLI octanol swissprot:HSLO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HSLO_ECOLI pepcoil swissprot:HSLO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HSLO_ECOLI pepdigest swissprot:HSLO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HSLO_ECOLI pepinfo swissprot:HSLO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HSLO_ECOLI pepnet swissprot:HSLO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HSLO_ECOLI pepstats swissprot:HSLO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HSLO_ECOLI pepwheel swissprot:HSLO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HSLO_ECOLI pepwindow swissprot:HSLO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HSLO_ECOLI sigcleave swissprot:HSLO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HSLO_ECOLI ## Database ID URL or Descriptions # AltName Autoinducer 2-degrading protein LsrG {ECO:0000255|HAMAP-Rule MF_02051} # AltName LSRG_ECOLI Phospho-(S)-4,5-dihydroxy-2,3-pentanedione isomerase {ECO 0000255|HAMAP-Rule MF_02051, ECO 0000303|PubMed 21454635} # AltName Phospho-AI-2 isomerase {ECO:0000255|HAMAP-Rule MF_02051} # BioGrid 4260228 10 # CATALYTIC ACTIVITY LSRG_ECOLI (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione = 3-hydroxy-5-phosphonooxypentane-2,4-dione. {ECO 0000255|HAMAP- Rule MF_02051, ECO 0000269|PubMed 21454635}. # EcoGene EG13811 lsrG # FUNCTION LSRG_ECOLI Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the conversion of (4S)-4-hydroxy-5- phosphonooxypentane-2,3-dione (P-DPD) to 3-hydroxy-5- phosphonooxypentane-2,4-dione (P-HPD). {ECO 0000255|HAMAP- Rule MF_02051, ECO 0000269|PubMed 17274596, ECO 0000269|PubMed 21454635}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0016853 isomerase activity; IDA:EcoCyc. # GO_function GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016853 isomerase activity # HAMAP MF_02051 LsrG # INDUCTION LSRG_ECOLI In the absence of AI-2, repressed by LsrR. Induced by AI-2, via release of the LsrR repressor. In the absence of glucose, induced by cAMP-CRP by direct binding to the upstream region of the lsr promoter. {ECO 0000269|PubMed 15601708, ECO 0000269|PubMed 15743955}. # IntAct P64461 5 # InterPro IPR007138 ABM_dom # InterPro IPR011008 Dimeric_a/b-barrel # InterPro IPR033672 LsrG # Organism LSRG_ECOLI Escherichia coli (strain K12) # PATRIC 32118332 VBIEscCol129921_1586 # PDB 3QMQ X-ray; 1.80 A; A/B/C/D=1-96 # PIR A64906 A64906 # PROSITE PS51725 ABM # Pfam PF03992 ABM # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase {ECO:0000255|HAMAP-Rule MF_02051} # RefSeq NP_416035 NC_000913.3 # RefSeq WP_000558527 NZ_LN832404.1 # SIMILARITY Belongs to the LsrG family. {ECO:0000255|HAMAP- Rule MF_02051}. # SIMILARITY Contains 1 ABM domain. {ECO:0000255|HAMAP- Rule MF_02051}. # SUBCELLULAR LOCATION LSRG_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_02051}. # SUBUNIT LSRG_ECOLI Homodimer. {ECO 0000255|HAMAP-Rule MF_02051, ECO 0000269|PubMed 21454635}. # SUPFAM SSF54909 SSF54909 # eggNOG COG1359 LUCA # eggNOG ENOG4105K34 Bacteria BLAST swissprot:LSRG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LSRG_ECOLI BioCyc ECOL316407:JW1511-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1511-MONOMER BioCyc EcoCyc:G6805-MONOMER http://biocyc.org/getid?id=EcoCyc:G6805-MONOMER BioCyc MetaCyc:G6805-MONOMER http://biocyc.org/getid?id=MetaCyc:G6805-MONOMER COG COG1359 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1359 DIP DIP-47853N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47853N DOI 10.1021/cb600444h http://dx.doi.org/10.1021/cb600444h DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M111.230227 http://dx.doi.org/10.1074/jbc.M111.230227 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.187.1.238-248.2005 http://dx.doi.org/10.1128/JB.187.1.238-248.2005 DOI 10.1128/JB.187.6.2066-2076.2005 http://dx.doi.org/10.1128/JB.187.6.2066-2076.2005 EC_number EC:5.3.1.32 {ECO:0000255|HAMAP-Rule:MF_02051, ECO:0000269|PubMed:21454635} http://www.genome.jp/dbget-bin/www_bget?EC:5.3.1.32 {ECO:0000255|HAMAP-Rule:MF_02051, ECO:0000269|PubMed:21454635} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 5.3.1.32 {ECO:0000255|HAMAP-Rule:MF_02051, ECO:0000269|PubMed:21454635} http://enzyme.expasy.org/EC/5.3.1.32 {ECO:0000255|HAMAP-Rule:MF_02051, ECO:0000269|PubMed:21454635} EchoBASE EB3572 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3572 EcoGene EG13811 http://www.ecogene.org/geneInfo.php?eg_id=EG13811 EnsemblBacteria AAC74591 http://www.ensemblgenomes.org/id/AAC74591 EnsemblBacteria AAC74591 http://www.ensemblgenomes.org/id/AAC74591 EnsemblBacteria BAE76458 http://www.ensemblgenomes.org/id/BAE76458 EnsemblBacteria BAE76458 http://www.ensemblgenomes.org/id/BAE76458 EnsemblBacteria BAE76458 http://www.ensemblgenomes.org/id/BAE76458 EnsemblBacteria b1518 http://www.ensemblgenomes.org/id/b1518 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GO_function GO:0016861 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016861 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GeneID 946073 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946073 HAMAP MF_02051 http://hamap.expasy.org/unirule/MF_02051 HOGENOM HOG000145619 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000145619&db=HOGENOM6 InParanoid P64461 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P64461 IntAct P64461 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P64461* IntEnz 5.3.1.32 {ECO:0000255|HAMAP-Rule:MF_02051, ECO:0000269|PubMed:21454635} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.3.1.32 {ECO:0000255|HAMAP-Rule:MF_02051, ECO:0000269|PubMed:21454635} InterPro IPR007138 http://www.ebi.ac.uk/interpro/entry/IPR007138 InterPro IPR011008 http://www.ebi.ac.uk/interpro/entry/IPR011008 InterPro IPR033672 http://www.ebi.ac.uk/interpro/entry/IPR033672 KEGG_Gene ecj:JW1511 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1511 KEGG_Gene eco:b1518 http://www.genome.jp/dbget-bin/www_bget?eco:b1518 KEGG_Orthology KO:K11530 http://www.genome.jp/dbget-bin/www_bget?KO:K11530 OMA NIPTRFY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NIPTRFY PDB 3QMQ http://www.ebi.ac.uk/pdbe-srv/view/entry/3QMQ PDBsum 3QMQ http://www.ebi.ac.uk/pdbsum/3QMQ PROSITE PS51725 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51725 PSORT swissprot:LSRG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LSRG_ECOLI PSORT-B swissprot:LSRG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LSRG_ECOLI PSORT2 swissprot:LSRG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LSRG_ECOLI Pfam PF03992 http://pfam.xfam.org/family/PF03992 Phobius swissprot:LSRG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LSRG_ECOLI ProteinModelPortal P64461 http://www.proteinmodelportal.org/query/uniprot/P64461 PubMed 15601708 http://www.ncbi.nlm.nih.gov/pubmed/15601708 PubMed 15743955 http://www.ncbi.nlm.nih.gov/pubmed/15743955 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17274596 http://www.ncbi.nlm.nih.gov/pubmed/17274596 PubMed 21454635 http://www.ncbi.nlm.nih.gov/pubmed/21454635 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416035 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416035 RefSeq WP_000558527 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000558527 SMR P64461 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P64461 STRING 511145.b1518 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1518&targetmode=cogs STRING COG1359 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1359&targetmode=cogs SUPFAM SSF54909 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54909 UniProtKB LSRG_ECOLI http://www.uniprot.org/uniprot/LSRG_ECOLI UniProtKB-AC P64461 http://www.uniprot.org/uniprot/P64461 charge swissprot:LSRG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LSRG_ECOLI eggNOG COG1359 http://eggnogapi.embl.de/nog_data/html/tree/COG1359 eggNOG ENOG4105K34 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K34 epestfind swissprot:LSRG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LSRG_ECOLI garnier swissprot:LSRG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LSRG_ECOLI helixturnhelix swissprot:LSRG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LSRG_ECOLI hmoment swissprot:LSRG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LSRG_ECOLI iep swissprot:LSRG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LSRG_ECOLI inforesidue swissprot:LSRG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LSRG_ECOLI octanol swissprot:LSRG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LSRG_ECOLI pepcoil swissprot:LSRG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LSRG_ECOLI pepdigest swissprot:LSRG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LSRG_ECOLI pepinfo swissprot:LSRG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LSRG_ECOLI pepnet swissprot:LSRG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LSRG_ECOLI pepstats swissprot:LSRG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LSRG_ECOLI pepwheel swissprot:LSRG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LSRG_ECOLI pepwindow swissprot:LSRG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LSRG_ECOLI sigcleave swissprot:LSRG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LSRG_ECOLI ## Database ID URL or Descriptions # BioGrid 4259758 13 # EcoGene EG13332 yafT # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GOslim_component GO:0005886 plasma membrane # Organism YAFT_ECOLI Escherichia coli (strain K12) # PATRIC 32115547 VBIEscCol129921_0218 # PIR B64746 B64746 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAFT_ECOLI Uncharacterized lipoprotein YafT # RefSeq NP_414752 NC_000913.3 # RefSeq WP_001086141 NZ_LN832404.1 # SUBCELLULAR LOCATION YAFT_ECOLI Cell membrane {ECO 0000305}; Lipid-anchor {ECO 0000305}. # eggNOG ENOG410600K Bacteria # eggNOG ENOG41128QG LUCA BLAST swissprot:YAFT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAFT_ECOLI BioCyc ECOL316407:JW0206-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0206-MONOMER BioCyc EcoCyc:G6101-MONOMER http://biocyc.org/getid?id=EcoCyc:G6101-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EchoBASE EB3116 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3116 EcoGene EG13332 http://www.ecogene.org/geneInfo.php?eg_id=EG13332 EnsemblBacteria AAC73321 http://www.ensemblgenomes.org/id/AAC73321 EnsemblBacteria AAC73321 http://www.ensemblgenomes.org/id/AAC73321 EnsemblBacteria BAA77887 http://www.ensemblgenomes.org/id/BAA77887 EnsemblBacteria BAA77887 http://www.ensemblgenomes.org/id/BAA77887 EnsemblBacteria BAA77887 http://www.ensemblgenomes.org/id/BAA77887 EnsemblBacteria b0217 http://www.ensemblgenomes.org/id/b0217 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 949009 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949009 HOGENOM HOG000116945 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000116945&db=HOGENOM6 IntAct P77339 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77339* KEGG_Gene ecj:JW0206 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0206 KEGG_Gene eco:b0217 http://www.genome.jp/dbget-bin/www_bget?eco:b0217 OMA APEAIMQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=APEAIMQ PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YAFT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAFT_ECOLI PSORT-B swissprot:YAFT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAFT_ECOLI PSORT2 swissprot:YAFT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAFT_ECOLI Phobius swissprot:YAFT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAFT_ECOLI ProteinModelPortal P77339 http://www.proteinmodelportal.org/query/uniprot/P77339 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414752 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414752 RefSeq WP_001086141 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001086141 STRING 511145.b0217 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0217&targetmode=cogs UniProtKB YAFT_ECOLI http://www.uniprot.org/uniprot/YAFT_ECOLI UniProtKB-AC P77339 http://www.uniprot.org/uniprot/P77339 charge swissprot:YAFT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAFT_ECOLI eggNOG ENOG410600K http://eggnogapi.embl.de/nog_data/html/tree/ENOG410600K eggNOG ENOG41128QG http://eggnogapi.embl.de/nog_data/html/tree/ENOG41128QG epestfind swissprot:YAFT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAFT_ECOLI garnier swissprot:YAFT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAFT_ECOLI helixturnhelix swissprot:YAFT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAFT_ECOLI hmoment swissprot:YAFT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAFT_ECOLI iep swissprot:YAFT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAFT_ECOLI inforesidue swissprot:YAFT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAFT_ECOLI octanol swissprot:YAFT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAFT_ECOLI pepcoil swissprot:YAFT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAFT_ECOLI pepdigest swissprot:YAFT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAFT_ECOLI pepinfo swissprot:YAFT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAFT_ECOLI pepnet swissprot:YAFT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAFT_ECOLI pepstats swissprot:YAFT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAFT_ECOLI pepwheel swissprot:YAFT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAFT_ECOLI pepwindow swissprot:YAFT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAFT_ECOLI sigcleave swissprot:YAFT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAFT_ECOLI ## Database ID URL or Descriptions # BioGrid 4262921 11 # CATALYTIC ACTIVITY ATZN_ECOLI ATP + H(2)O + Cd(2+)(In) = ADP + phosphate + Cd(2+)(Out). # CATALYTIC ACTIVITY ATZN_ECOLI ATP + H(2)O + Zn(2+)(In) = ADP + phosphate + Zn(2+)(Out). # CDD cd00371 HMA # EcoGene EG12215 zntA # FUNCTION ATZN_ECOLI Involved in export of lead, cadmium, zinc and mercury. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_component GO:0016021 integral component of membrane; IDA:EcoCyc. # GO_component GO:0043231 intracellular membrane-bounded organelle; IBA:GO_Central. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0008551 cadmium-exporting ATPase activity; IDA:EcoCyc. # GO_function GO:0015087 cobalt ion transmembrane transporter activity; IMP:EcoCyc. # GO_function GO:0015094 lead ion transmembrane transporter activity; IMP:EcoCyc. # GO_function GO:0015099 nickel cation transmembrane transporter activity; IMP:EcoCyc. # GO_function GO:0016463 zinc-exporting ATPase activity; IDA:EcoCyc. # GO_function GO:0016887 ATPase activity; ISA:EcoliWiki. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006824 cobalt ion transport; IMP:EcoCyc. # GO_process GO:0006829 zinc II ion transport; IMP:EcoliWiki. # GO_process GO:0010312 detoxification of zinc ion; IMP:EcoliWiki. # GO_process GO:0015692 lead ion transport; IMP:EcoCyc. # GO_process GO:0046686 response to cadmium ion; IMP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043226 organelle # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # Gene3D 2.70.150.10 -; 1. # Gene3D 3.40.1110.10 -; 1. # Gene3D 3.40.50.1000 -; 2. # IntAct P37617 8 # InterPro IPR001757 P_typ_ATPase # InterPro IPR006121 HMA_dom # InterPro IPR008250 ATPase_P-typ_transduc_dom_A # InterPro IPR017969 Heavy-metal-associated_CS # InterPro IPR018303 ATPase_P-typ_P_site # InterPro IPR023214 HAD-like_dom # InterPro IPR023299 ATPase_P-typ_cyto_domN # InterPro IPR027256 P-typ_ATPase_IB # KEGG_Brite ko01000 Enzymes # Organism ATZN_ECOLI Escherichia coli (strain K12) # PATRIC 32122382 VBIEscCol129921_3568 # PDB 1MWY NMR; -; A=46-118 # PDB 1MWZ NMR; -; A=46-118 # PIR S47688 S47688 # PRINTS PR00120 HATPASE # PROSITE PS00154 ATPASE_E1_E2 # PROSITE PS01047 HMA_1 # PROSITE PS50846 HMA_2 # Pfam PF00122 E1-E2_ATPase # Pfam PF00403 HMA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ATZN_ECOLI Lead, cadmium, zinc and mercury-transporting ATPase # RefSeq NP_417926 NC_000913.3 # RefSeq WP_000106551 NZ_LN832404.1 # SIMILARITY Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. {ECO 0000305}. # SIMILARITY Contains 1 HMA domain. {ECO:0000255|PROSITE- ProRule PRU00280}. # SUBCELLULAR LOCATION ATZN_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF55008 SSF55008 # SUPFAM SSF56784 SSF56784; 2 # TCDB 3.A.3.6 the p-type atpase (p-atpase) superfamily # TIGRFAMs TIGR01494 ATPase_P-type # TIGRFAMs TIGR01525 ATPase-IB_hvy # eggNOG COG2217 LUCA # eggNOG ENOG4105C59 Bacteria BLAST swissprot:ATZN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ATZN_ECOLI BioCyc ECOL316407:JW3434-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3434-MONOMER BioCyc EcoCyc:YHHO-MONOMER http://biocyc.org/getid?id=EcoCyc:YHHO-MONOMER BioCyc MetaCyc:YHHO-MONOMER http://biocyc.org/getid?id=MetaCyc:YHHO-MONOMER COG COG2217 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2217 DIP DIP-12947N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12947N DOI 10.1016/S0022-2836(02)01007-0 http://dx.doi.org/10.1016/S0022-2836(02)01007-0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.94.26.14326 http://dx.doi.org/10.1073/pnas.94.26.14326 DOI 10.1074/jbc.275.6.3873 http://dx.doi.org/10.1074/jbc.275.6.3873 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1111/j.1365-2958.1997.mmi518.x http://dx.doi.org/10.1111/j.1365-2958.1997.mmi518.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.3.3 http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.3 EC_number EC:3.6.3.5 http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.5 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.6.3.3 http://enzyme.expasy.org/EC/3.6.3.3 ENZYME 3.6.3.5 http://enzyme.expasy.org/EC/3.6.3.5 EchoBASE EB2129 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2129 EcoGene EG12215 http://www.ecogene.org/geneInfo.php?eg_id=EG12215 EnsemblBacteria AAC76494 http://www.ensemblgenomes.org/id/AAC76494 EnsemblBacteria AAC76494 http://www.ensemblgenomes.org/id/AAC76494 EnsemblBacteria BAE77824 http://www.ensemblgenomes.org/id/BAE77824 EnsemblBacteria BAE77824 http://www.ensemblgenomes.org/id/BAE77824 EnsemblBacteria BAE77824 http://www.ensemblgenomes.org/id/BAE77824 EnsemblBacteria b3469 http://www.ensemblgenomes.org/id/b3469 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0043231 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008551 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008551 GO_function GO:0015087 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015087 GO_function GO:0015094 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015094 GO_function GO:0015099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015099 GO_function GO:0016463 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016463 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006824 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006824 GO_process GO:0006829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006829 GO_process GO:0010312 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010312 GO_process GO:0015692 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015692 GO_process GO:0046686 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046686 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 2.70.150.10 http://www.cathdb.info/version/latest/superfamily/2.70.150.10 Gene3D 3.40.1110.10 http://www.cathdb.info/version/latest/superfamily/3.40.1110.10 Gene3D 3.40.50.1000 http://www.cathdb.info/version/latest/superfamily/3.40.50.1000 GeneID 947972 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947972 HOGENOM HOG000250399 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000250399&db=HOGENOM6 InParanoid P37617 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37617 IntAct P37617 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37617* IntEnz 3.6.3.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.3 IntEnz 3.6.3.5 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.5 InterPro IPR001757 http://www.ebi.ac.uk/interpro/entry/IPR001757 InterPro IPR006121 http://www.ebi.ac.uk/interpro/entry/IPR006121 InterPro IPR008250 http://www.ebi.ac.uk/interpro/entry/IPR008250 InterPro IPR017969 http://www.ebi.ac.uk/interpro/entry/IPR017969 InterPro IPR018303 http://www.ebi.ac.uk/interpro/entry/IPR018303 InterPro IPR023214 http://www.ebi.ac.uk/interpro/entry/IPR023214 InterPro IPR023299 http://www.ebi.ac.uk/interpro/entry/IPR023299 InterPro IPR027256 http://www.ebi.ac.uk/interpro/entry/IPR027256 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3434 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3434 KEGG_Gene eco:b3469 http://www.genome.jp/dbget-bin/www_bget?eco:b3469 KEGG_Orthology KO:K01534 http://www.genome.jp/dbget-bin/www_bget?KO:K01534 MINT MINT-1256950 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1256950 OMA EPWETWI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EPWETWI PDB 1MWY http://www.ebi.ac.uk/pdbe-srv/view/entry/1MWY PDB 1MWZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1MWZ PDBsum 1MWY http://www.ebi.ac.uk/pdbsum/1MWY PDBsum 1MWZ http://www.ebi.ac.uk/pdbsum/1MWZ PRINTS PR00120 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00120 PROSITE PS00154 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00154 PROSITE PS01047 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01047 PROSITE PS50846 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50846 PSORT swissprot:ATZN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ATZN_ECOLI PSORT-B swissprot:ATZN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ATZN_ECOLI PSORT2 swissprot:ATZN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ATZN_ECOLI Pfam PF00122 http://pfam.xfam.org/family/PF00122 Pfam PF00403 http://pfam.xfam.org/family/PF00403 Phobius swissprot:ATZN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ATZN_ECOLI PhylomeDB P37617 http://phylomedb.org/?seqid=P37617 ProteinModelPortal P37617 http://www.proteinmodelportal.org/query/uniprot/P37617 PubMed 10660539 http://www.ncbi.nlm.nih.gov/pubmed/10660539 PubMed 12417201 http://www.ncbi.nlm.nih.gov/pubmed/12417201 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9364914 http://www.ncbi.nlm.nih.gov/pubmed/9364914 PubMed 9405611 http://www.ncbi.nlm.nih.gov/pubmed/9405611 RefSeq NP_417926 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417926 RefSeq WP_000106551 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000106551 SMR P37617 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37617 STRING 511145.b3469 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3469&targetmode=cogs STRING COG2217 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2217&targetmode=cogs SUPFAM SSF55008 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55008 SUPFAM SSF56784 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784 TCDB 3.A.3.6 http://www.tcdb.org/search/result.php?tc=3.A.3.6 TIGRFAMs TIGR01494 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01494 TIGRFAMs TIGR01525 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01525 UniProtKB ATZN_ECOLI http://www.uniprot.org/uniprot/ATZN_ECOLI UniProtKB-AC P37617 http://www.uniprot.org/uniprot/P37617 charge swissprot:ATZN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ATZN_ECOLI eggNOG COG2217 http://eggnogapi.embl.de/nog_data/html/tree/COG2217 eggNOG ENOG4105C59 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C59 epestfind swissprot:ATZN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ATZN_ECOLI garnier swissprot:ATZN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ATZN_ECOLI helixturnhelix swissprot:ATZN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ATZN_ECOLI hmoment swissprot:ATZN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ATZN_ECOLI iep swissprot:ATZN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ATZN_ECOLI inforesidue swissprot:ATZN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ATZN_ECOLI octanol swissprot:ATZN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ATZN_ECOLI pepcoil swissprot:ATZN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ATZN_ECOLI pepdigest swissprot:ATZN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ATZN_ECOLI pepinfo swissprot:ATZN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ATZN_ECOLI pepnet swissprot:ATZN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ATZN_ECOLI pepstats swissprot:ATZN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ATZN_ECOLI pepwheel swissprot:ATZN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ATZN_ECOLI pepwindow swissprot:ATZN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ATZN_ECOLI sigcleave swissprot:ATZN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ATZN_ECOLI ## Database ID URL or Descriptions # BioGrid 4260963 257 # CDD cd06261 TM_PBP2 # EcoGene EG13788 ddpC # FUNCTION DDPC_ECOLI Part of the ABC transporter complex DdpABCDF, which is probably involved in D,D-dipeptide transport. Probably responsible for the translocation of the substrate across the membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoliWiki. # GO_function GO:0022857 transmembrane transporter activity; IBA:GO_Central. # GO_function GO:0042936 dipeptide transporter activity; IBA:GO_Central. # GO_process GO:0015031 protein transport; IEA:UniProtKB-KW. # GO_process GO:0055085 transmembrane transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # Gene3D 1.10.3720.10 -; 1. # INDUCTION Induced by RpoS in stationary phase. {ECO:0000269|PubMed 9751644}. # IntAct P77463 2 # InterPro IPR000515 MetI-like # InterPro IPR025966 OppC_N # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00239 Peptides/nickel transport system # KEGG_Brite ko02000 Transporters # Organism DDPC_ECOLI Escherichia coli (strain K12) # PATRIC 32118264 VBIEscCol129921_1552 # PIR H64901 H64901 # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Pfam PF12911 OppC_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DDPC_ECOLI Probable D,D-dipeptide transport system permease protein DdpC # RefSeq NP_416002 NC_000913.3 # RefSeq WP_000979626 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION DDPC_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT The complex is composed of two ATP-binding proteins (DdpD and DdpF), two transmembrane proteins (DdpB and DdpC) and a solute-binding protein (DdpA). {ECO 0000305}. # SUPFAM SSF161098 SSF161098 # TCDB 3.A.1.5.38 the atp-binding cassette (abc) superfamily # eggNOG COG1173 LUCA # eggNOG ENOG4105C2T Bacteria BLAST swissprot:DDPC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DDPC_ECOLI BioCyc ECOL316407:JW1480-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1480-MONOMER BioCyc EcoCyc:YDDQ-MONOMER http://biocyc.org/getid?id=EcoCyc:YDDQ-MONOMER COG COG1173 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1173 DOI 10.1016/S1074-5521(98)90005-9 http://dx.doi.org/10.1016/S1074-5521(98)90005-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.052018199 http://dx.doi.org/10.1073/pnas.052018199 DOI 10.1073/pnas.96.20.11028 http://dx.doi.org/10.1073/pnas.96.20.11028 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3549 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3549 EcoGene EG13788 http://www.ecogene.org/geneInfo.php?eg_id=EG13788 EnsemblBacteria AAC74558 http://www.ensemblgenomes.org/id/AAC74558 EnsemblBacteria AAC74558 http://www.ensemblgenomes.org/id/AAC74558 EnsemblBacteria BAA15140 http://www.ensemblgenomes.org/id/BAA15140 EnsemblBacteria BAA15140 http://www.ensemblgenomes.org/id/BAA15140 EnsemblBacteria BAA15140 http://www.ensemblgenomes.org/id/BAA15140 EnsemblBacteria b1485 http://www.ensemblgenomes.org/id/b1485 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GO_function GO:0042936 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042936 GO_process GO:0015031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 946028 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946028 HOGENOM HOG000171368 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000171368&db=HOGENOM6 InParanoid P77463 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77463 IntAct P77463 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77463* InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 InterPro IPR025966 http://www.ebi.ac.uk/interpro/entry/IPR025966 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1480 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1480 KEGG_Gene eco:b1485 http://www.genome.jp/dbget-bin/www_bget?eco:b1485 KEGG_Orthology KO:K02034 http://www.genome.jp/dbget-bin/www_bget?KO:K02034 OMA PDWGLDL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PDWGLDL PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:DDPC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DDPC_ECOLI PSORT-B swissprot:DDPC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DDPC_ECOLI PSORT2 swissprot:DDPC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DDPC_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Pfam PF12911 http://pfam.xfam.org/family/PF12911 Phobius swissprot:DDPC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DDPC_ECOLI PhylomeDB P77463 http://phylomedb.org/?seqid=P77463 ProteinModelPortal P77463 http://www.proteinmodelportal.org/query/uniprot/P77463 PubMed 10500118 http://www.ncbi.nlm.nih.gov/pubmed/10500118 PubMed 11867724 http://www.ncbi.nlm.nih.gov/pubmed/11867724 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9751644 http://www.ncbi.nlm.nih.gov/pubmed/9751644 RefSeq NP_416002 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416002 RefSeq WP_000979626 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000979626 STRING 511145.b1485 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1485&targetmode=cogs STRING COG1173 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1173&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.5.38 http://www.tcdb.org/search/result.php?tc=3.A.1.5.38 UniProtKB DDPC_ECOLI http://www.uniprot.org/uniprot/DDPC_ECOLI UniProtKB-AC P77463 http://www.uniprot.org/uniprot/P77463 charge swissprot:DDPC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DDPC_ECOLI eggNOG COG1173 http://eggnogapi.embl.de/nog_data/html/tree/COG1173 eggNOG ENOG4105C2T http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C2T epestfind swissprot:DDPC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DDPC_ECOLI garnier swissprot:DDPC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DDPC_ECOLI helixturnhelix swissprot:DDPC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DDPC_ECOLI hmoment swissprot:DDPC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DDPC_ECOLI iep swissprot:DDPC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DDPC_ECOLI inforesidue swissprot:DDPC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DDPC_ECOLI octanol swissprot:DDPC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DDPC_ECOLI pepcoil swissprot:DDPC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DDPC_ECOLI pepdigest swissprot:DDPC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DDPC_ECOLI pepinfo swissprot:DDPC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DDPC_ECOLI pepnet swissprot:DDPC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DDPC_ECOLI pepstats swissprot:DDPC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DDPC_ECOLI pepwheel swissprot:DDPC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DDPC_ECOLI pepwindow swissprot:DDPC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DDPC_ECOLI sigcleave swissprot:DDPC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DDPC_ECOLI ## Database ID URL or Descriptions # BioGrid 4261112 319 # DOMAIN FTSQ_ECOLI The C-terminal periplasmic region is necessary and sufficient for septal targeting. The transmembrane region contributes to localization to the cell division site. Three periplasmic subdomains are involved in the interactions with other cell division proteins. Localization and recruitment require two separate domains. {ECO 0000269|PubMed 17185541, ECO 0000269|PubMed 17693520, ECO 0000269|PubMed 18312270, ECO 0000269|PubMed 9829918, ECO 0000269|PubMed 9882666}. # EcoGene EG10342 ftsQ # FUNCTION FTSQ_ECOLI Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. {ECO 0000255|HAMAP-Rule MF_00911, ECO 0000269|PubMed 17185541, ECO 0000269|PubMed 19233928}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IDA:EcoliWiki. # GO_component GO:0032153 cell division site; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IPI:IntAct. # GO_process GO:0000917 barrier septum assembly; IMP:EcoliWiki. # GO_process GO:0043093 FtsZ-dependent cytokinesis; IMP:EcoCyc. # GO_process GO:0051301 cell division; IMP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0008150 biological_process # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0051301 cell division # HAMAP MF_00911 FtsQ_subfam # INDUCTION Repressed by hydroxyurea. {ECO:0000269|PubMed 20005847}. # INTERACTION FTSQ_ECOLI Self; NbExp=6; IntAct=EBI-1130157, EBI-1130157; P0A6S5 ftsB; NbExp=10; IntAct=EBI-1130157, EBI-1113953; P0AD68 ftsI; NbExp=5; IntAct=EBI-1130157, EBI-548564; P46889 ftsK; NbExp=3; IntAct=EBI-1130157, EBI-550795; P0AEN4 ftsL; NbExp=11; IntAct=EBI-1130157, EBI-1119082; P29131 ftsN; NbExp=7; IntAct=EBI-1130157, EBI-1134233; P0ABG4 ftsW; NbExp=3; IntAct=EBI-1130157, EBI-1214767; P58034 ymgF; NbExp=3; IntAct=EBI-1130157, EBI-1214577; # IntAct P06136 19 # InterPro IPR005548 Cell_div_FtsQ/DivIB # InterPro IPR013685 POTRA_FtsQ_type # InterPro IPR026579 FtsQ # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko03036 Chromosome # KEGG_Pathway ko04112 Cell cycle - Caulobacter # Organism FTSQ_ECOLI Escherichia coli (strain K12) # PATRIC 32115291 VBIEscCol129921_0097 # PDB 2VH1 X-ray; 2.70 A; A/B=58-276 # PDB 4UE4 EM; 7.00 A; B=29-50 # PDB 4V6M EM; 7.1 A; Z=22-103 # PIR S10852 CEECQ # PROSITE PS51779 POTRA # Pfam PF03799 FtsQ # Pfam PF08478 POTRA_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Cell division protein FtsQ {ECO:0000255|HAMAP-Rule MF_00911} # RefSeq NP_414635 NC_000913.3 # RefSeq WP_000075748 NZ_LN832404.1 # SIMILARITY Belongs to the FtsQ/DivIB family. FtsQ subfamily. {ECO:0000255|HAMAP-Rule MF_00911}. # SIMILARITY Contains 1 POTRA domain. {ECO:0000255|PROSITE- ProRule PRU01115}. # SUBCELLULAR LOCATION FTSQ_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_00911, ECO 0000269|PubMed 11415986, ECO 0000269|PubMed 11703663, ECO 0000269|PubMed 11948172, ECO 0000269|PubMed 15165235, ECO 0000269|PubMed 17693520, ECO 0000269|PubMed 2007547, ECO 0000269|PubMed 9829918, ECO 0000269|PubMed 9882666}; Single-pass type II membrane protein {ECO 0000255|HAMAP-Rule MF_00911, ECO 0000269|PubMed 11415986, ECO 0000269|PubMed 11703663, ECO 0000269|PubMed 11948172, ECO 0000269|PubMed 15165235, ECO 0000269|PubMed 17693520, ECO 0000269|PubMed 2007547, ECO 0000269|PubMed 9829918, ECO 0000269|PubMed 9882666}. Note=Localizes to the division septum. Localization requires FtsZ, FtsA, ZipA and FtsK, but not FtsL, FtsI and FtsN. Insertion into the membrane requires YidC and the Sec translocase. # SUBUNIT FTSQ_ECOLI Part of a complex composed of FtsB, FtsL and FtsQ. The complex can be formed before its localization to the division site. This tripartite complex can be divided further into a subcomplex of FtsB and FtsL, which forms in the absence of FtsQ. Interacts with FtsA, FtsK, FtsL, FtsB, FtsW, FtsI, FtsN, FtsX and YmgF. {ECO 0000255|HAMAP-Rule MF_00911, ECO 0000269|PubMed 15165235, ECO 0000269|PubMed 15774864, ECO 0000269|PubMed 17185541, ECO 0000269|PubMed 19233928}. # eggNOG COG1589 LUCA # eggNOG ENOG4105K7E Bacteria BLAST swissprot:FTSQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FTSQ_ECOLI BioCyc ECOL316407:JW0091-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0091-MONOMER BioCyc EcoCyc:EG10342-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10342-MONOMER COG COG1589 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1589 DIP DIP-9706N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9706N DOI 10.1016/0022-2836(85)90290-6 http://dx.doi.org/10.1016/0022-2836(85)90290-6 DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsmb.2026 http://dx.doi.org/10.1038/nsmb.2026 DOI 10.1046/j.1365-2958.2001.02640.x http://dx.doi.org/10.1046/j.1365-2958.2001.02640.x DOI 10.1093/embo-reports/kve108 http://dx.doi.org/10.1093/embo-reports/kve108 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1099/mic.0.2006/000265-0 http://dx.doi.org/10.1099/mic.0.2006/000265-0 DOI 10.1111/j.1365-2958.2004.04044.x http://dx.doi.org/10.1111/j.1365-2958.2004.04044.x DOI 10.1111/j.1365-2958.2008.06141.x http://dx.doi.org/10.1111/j.1365-2958.2008.06141.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00723-07 http://dx.doi.org/10.1128/JB.00723-07 DOI 10.1128/JB.01597-08 http://dx.doi.org/10.1128/JB.01597-08 DOI 10.1128/JB.184.9.2552-2556.2002 http://dx.doi.org/10.1128/JB.184.9.2552-2556.2002 DOI 10.1128/JB.187.7.2233-2243.2005 http://dx.doi.org/10.1128/JB.187.7.2233-2243.2005 DOI 10.1186/1472-6807-11-28 http://dx.doi.org/10.1186/1472-6807-11-28 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K02668 http://www.ebi.ac.uk/ena/data/view/K02668 EMBL M14029 http://www.ebi.ac.uk/ena/data/view/M14029 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X55034 http://www.ebi.ac.uk/ena/data/view/X55034 EchoBASE EB0338 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0338 EcoGene EG10342 http://www.ecogene.org/geneInfo.php?eg_id=EG10342 EnsemblBacteria AAC73204 http://www.ensemblgenomes.org/id/AAC73204 EnsemblBacteria AAC73204 http://www.ensemblgenomes.org/id/AAC73204 EnsemblBacteria BAB96661 http://www.ensemblgenomes.org/id/BAB96661 EnsemblBacteria BAB96661 http://www.ensemblgenomes.org/id/BAB96661 EnsemblBacteria BAB96661 http://www.ensemblgenomes.org/id/BAB96661 EnsemblBacteria b0093 http://www.ensemblgenomes.org/id/b0093 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0032153 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032153 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0000917 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000917 GO_process GO:0043093 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043093 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GeneID 944823 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944823 HAMAP MF_00911 http://hamap.expasy.org/unirule/MF_00911 HOGENOM HOG000255872 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000255872&db=HOGENOM6 InParanoid P06136 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P06136 IntAct P06136 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P06136* InterPro IPR005548 http://www.ebi.ac.uk/interpro/entry/IPR005548 InterPro IPR013685 http://www.ebi.ac.uk/interpro/entry/IPR013685 InterPro IPR026579 http://www.ebi.ac.uk/interpro/entry/IPR026579 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene ecj:JW0091 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0091 KEGG_Gene eco:b0093 http://www.genome.jp/dbget-bin/www_bget?eco:b0093 KEGG_Orthology KO:K03589 http://www.genome.jp/dbget-bin/www_bget?KO:K03589 KEGG_Pathway ko04112 http://www.genome.jp/kegg-bin/show_pathway?ko04112 MINT MINT-1031860 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1031860 OMA VFEAPSH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VFEAPSH PDB 2VH1 http://www.ebi.ac.uk/pdbe-srv/view/entry/2VH1 PDB 4UE4 http://www.ebi.ac.uk/pdbe-srv/view/entry/4UE4 PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDBsum 2VH1 http://www.ebi.ac.uk/pdbsum/2VH1 PDBsum 4UE4 http://www.ebi.ac.uk/pdbsum/4UE4 PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PROSITE PS51779 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51779 PSORT swissprot:FTSQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FTSQ_ECOLI PSORT-B swissprot:FTSQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FTSQ_ECOLI PSORT2 swissprot:FTSQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FTSQ_ECOLI Pfam PF03799 http://pfam.xfam.org/family/PF03799 Pfam PF08478 http://pfam.xfam.org/family/PF08478 Phobius swissprot:FTSQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FTSQ_ECOLI PhylomeDB P06136 http://phylomedb.org/?seqid=P06136 ProteinModelPortal P06136 http://www.proteinmodelportal.org/query/uniprot/P06136 PubMed 11415986 http://www.ncbi.nlm.nih.gov/pubmed/11415986 PubMed 11703663 http://www.ncbi.nlm.nih.gov/pubmed/11703663 PubMed 11948172 http://www.ncbi.nlm.nih.gov/pubmed/11948172 PubMed 15165235 http://www.ncbi.nlm.nih.gov/pubmed/15165235 PubMed 15774864 http://www.ncbi.nlm.nih.gov/pubmed/15774864 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17185541 http://www.ncbi.nlm.nih.gov/pubmed/17185541 PubMed 17693520 http://www.ncbi.nlm.nih.gov/pubmed/17693520 PubMed 18312270 http://www.ncbi.nlm.nih.gov/pubmed/18312270 PubMed 19233928 http://www.ncbi.nlm.nih.gov/pubmed/19233928 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 2007547 http://www.ncbi.nlm.nih.gov/pubmed/2007547 PubMed 21499241 http://www.ncbi.nlm.nih.gov/pubmed/21499241 PubMed 21672257 http://www.ncbi.nlm.nih.gov/pubmed/21672257 PubMed 2228979 http://www.ncbi.nlm.nih.gov/pubmed/2228979 PubMed 2995680 http://www.ncbi.nlm.nih.gov/pubmed/2995680 PubMed 3528126 http://www.ncbi.nlm.nih.gov/pubmed/3528126 PubMed 6094474 http://www.ncbi.nlm.nih.gov/pubmed/6094474 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9829918 http://www.ncbi.nlm.nih.gov/pubmed/9829918 PubMed 9882666 http://www.ncbi.nlm.nih.gov/pubmed/9882666 RefSeq NP_414635 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414635 RefSeq WP_000075748 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000075748 SMR P06136 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P06136 STRING 511145.b0093 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0093&targetmode=cogs STRING COG1589 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1589&targetmode=cogs UniProtKB FTSQ_ECOLI http://www.uniprot.org/uniprot/FTSQ_ECOLI UniProtKB-AC P06136 http://www.uniprot.org/uniprot/P06136 charge swissprot:FTSQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FTSQ_ECOLI eggNOG COG1589 http://eggnogapi.embl.de/nog_data/html/tree/COG1589 eggNOG ENOG4105K7E http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K7E epestfind swissprot:FTSQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FTSQ_ECOLI garnier swissprot:FTSQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FTSQ_ECOLI helixturnhelix swissprot:FTSQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FTSQ_ECOLI hmoment swissprot:FTSQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FTSQ_ECOLI iep swissprot:FTSQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FTSQ_ECOLI inforesidue swissprot:FTSQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FTSQ_ECOLI octanol swissprot:FTSQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FTSQ_ECOLI pepcoil swissprot:FTSQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FTSQ_ECOLI pepdigest swissprot:FTSQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FTSQ_ECOLI pepinfo swissprot:FTSQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FTSQ_ECOLI pepnet swissprot:FTSQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FTSQ_ECOLI pepstats swissprot:FTSQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FTSQ_ECOLI pepwheel swissprot:FTSQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FTSQ_ECOLI pepwindow swissprot:FTSQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FTSQ_ECOLI sigcleave swissprot:FTSQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FTSQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4260919 2 # CATALYTIC ACTIVITY EUTT_ECOLI ATP + cob(I)yrinic acid a,c-diamide = triphosphate + adenosylcob(III)yrinic acid a,c-diamide. # CATALYTIC ACTIVITY EUTT_ECOLI ATP + cobinamide = triphosphate + adenosylcobinamide. # EcoGene EG14189 eutT # FUNCTION EUTT_ECOLI Converts CNB12 to ADOB12. {ECO 0000250}. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0008817 cob(I)yrinic acid a,c-diamide adenosyltransferase activity; IEA:UniProtKB-EC. # GO_process GO:0009236 cobalamin biosynthetic process; IEA:InterPro. # GO_process GO:0046336 ethanolamine catabolic process; IEA:UniProtKB-UniPathway. # GOslim_function GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.20.1200.10 -; 1. # IntAct P65643 7 # InterPro IPR009194 AdoCbl_synth_CblAdoTrfase_EutT # InterPro IPR016030 AdoCbl_synth_CblAdoTrfase-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00860 Porphyrin and chlorophyll metabolism # Organism EUTT_ECOLI Escherichia coli (strain K12) # PATHWAY EUTT_ECOLI Amine and polyamine degradation; ethanolamine degradation. # PATRIC 32120301 VBIEscCol129921_2553 # PIR B65021 B65021 # PIRSF PIRSF012294 ATR_EutT # Pfam PF01923 Cob_adeno_trans # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EUTT_ECOLI Ethanolamine utilization cobalamin adenosyltransferase # RefSeq NP_416954 NC_000913.3 # RefSeq WP_000651298 NZ_LN832404.1 # SUPFAM SSF89028 SSF89028 # eggNOG COG4812 LUCA # eggNOG ENOG4108PFF Bacteria BLAST swissprot:EUTT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EUTT_ECOLI BioCyc ECOL316407:JW2443-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2443-MONOMER BioCyc EcoCyc:G7289-MONOMER http://biocyc.org/getid?id=EcoCyc:G7289-MONOMER DIP DIP-9543N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9543N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.5.1.17 http://www.genome.jp/dbget-bin/www_bget?EC:2.5.1.17 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.5.1.17 http://enzyme.expasy.org/EC/2.5.1.17 EchoBASE EB3941 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3941 EcoGene EG14189 http://www.ecogene.org/geneInfo.php?eg_id=EG14189 EnsemblBacteria AAC75512 http://www.ensemblgenomes.org/id/AAC75512 EnsemblBacteria AAC75512 http://www.ensemblgenomes.org/id/AAC75512 EnsemblBacteria BAE76717 http://www.ensemblgenomes.org/id/BAE76717 EnsemblBacteria BAE76717 http://www.ensemblgenomes.org/id/BAE76717 EnsemblBacteria BAE76717 http://www.ensemblgenomes.org/id/BAE76717 EnsemblBacteria b2459 http://www.ensemblgenomes.org/id/b2459 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008817 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008817 GO_process GO:0009236 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009236 GO_process GO:0046336 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046336 GOslim_function GO:0016765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016765 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.20.1200.10 http://www.cathdb.info/version/latest/superfamily/1.20.1200.10 GeneID 946939 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946939 HOGENOM HOG000289182 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000289182&db=HOGENOM6 InParanoid P65643 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P65643 IntAct P65643 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P65643* IntEnz 2.5.1.17 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.5.1.17 InterPro IPR009194 http://www.ebi.ac.uk/interpro/entry/IPR009194 InterPro IPR016030 http://www.ebi.ac.uk/interpro/entry/IPR016030 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2443 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2443 KEGG_Gene eco:b2459 http://www.genome.jp/dbget-bin/www_bget?eco:b2459 KEGG_Orthology KO:K04032 http://www.genome.jp/dbget-bin/www_bget?KO:K04032 KEGG_Pathway ko00860 http://www.genome.jp/kegg-bin/show_pathway?ko00860 KEGG_Reaction rn:R01492 http://www.genome.jp/dbget-bin/www_bget?rn:R01492 OMA ACCELCH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ACCELCH PSORT swissprot:EUTT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EUTT_ECOLI PSORT-B swissprot:EUTT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EUTT_ECOLI PSORT2 swissprot:EUTT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EUTT_ECOLI Pfam PF01923 http://pfam.xfam.org/family/PF01923 Phobius swissprot:EUTT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EUTT_ECOLI ProteinModelPortal P65643 http://www.proteinmodelportal.org/query/uniprot/P65643 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416954 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416954 RefSeq WP_000651298 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000651298 STRING 511145.b2459 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2459&targetmode=cogs SUPFAM SSF89028 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF89028 UniProtKB EUTT_ECOLI http://www.uniprot.org/uniprot/EUTT_ECOLI UniProtKB-AC P65643 http://www.uniprot.org/uniprot/P65643 charge swissprot:EUTT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EUTT_ECOLI eggNOG COG4812 http://eggnogapi.embl.de/nog_data/html/tree/COG4812 eggNOG ENOG4108PFF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108PFF epestfind swissprot:EUTT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EUTT_ECOLI garnier swissprot:EUTT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EUTT_ECOLI helixturnhelix swissprot:EUTT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EUTT_ECOLI hmoment swissprot:EUTT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EUTT_ECOLI iep swissprot:EUTT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EUTT_ECOLI inforesidue swissprot:EUTT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EUTT_ECOLI octanol swissprot:EUTT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EUTT_ECOLI pepcoil swissprot:EUTT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EUTT_ECOLI pepdigest swissprot:EUTT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EUTT_ECOLI pepinfo swissprot:EUTT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EUTT_ECOLI pepnet swissprot:EUTT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EUTT_ECOLI pepstats swissprot:EUTT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EUTT_ECOLI pepwheel swissprot:EUTT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EUTT_ECOLI pepwindow swissprot:EUTT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EUTT_ECOLI sigcleave swissprot:EUTT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EUTT_ECOLI ## Database ID URL or Descriptions # AltName MRAY_ECOLI UDP-MurNAc-pentapeptide phosphotransferase # BioGrid 4261478 327 # CATALYTIC ACTIVITY MRAY_ECOLI UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala- D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D- Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. # CDD cd06852 GT_MraY # COFACTOR MRAY_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Name=Mn(2+); Xref=ChEBI CHEBI 29035; # EcoGene EG10604 mraY # FUNCTION MRAY_ECOLI First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan. {ECO 0000269|PubMed 1846850}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0008963 phospho-N-acetylmuramoyl-pentapeptide-transferase activity; IDA:EcoliWiki. # GO_function MRAY_ECOLI GO 0051992 UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine undecaprenyl-phosphate transferase activity; IEA UniProtKB-EC. # GO_process GO:0007049 cell cycle; IEA:UniProtKB-KW. # GO_process GO:0008360 regulation of cell shape; IEA:UniProtKB-KW. # GO_process GO:0009252 peptidoglycan biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0051301 cell division; IEA:UniProtKB-KW. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0007049 cell cycle # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0051301 cell division # GOslim_process GO:0071554 cell wall organization or biogenesis # HAMAP MF_00038 MraY # InterPro IPR000715 Glycosyl_transferase_4 # InterPro IPR003524 PNAcMuramoyl-5peptid_Trfase # InterPro IPR018480 PNAcMuramoyl-5peptid_Trfase_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00550 Peptidoglycan biosynthesis # Organism MRAY_ECOLI Escherichia coli (strain K12) # PANTHER PTHR22926 PTHR22926 # PATHWAY MRAY_ECOLI Cell wall biogenesis; peptidoglycan biosynthesis. # PATRIC 32115279 VBIEscCol129921_0091 # PIR S08395 S08395 # PROSITE PS01347 MRAY_1 # PROSITE PS01348 MRAY_2 # Pfam PF00953 Glycos_transf_4 # Pfam PF10555 MraY_sig1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MRAY_ECOLI Phospho-N-acetylmuramoyl-pentapeptide-transferase # RefSeq NP_414629 NC_000913.3 # RefSeq WP_000964131 NZ_LN832404.1 # SIMILARITY Belongs to the glycosyltransferase 4 family. MraY subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION MRAY_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # TCDB 9.B.146.1 the putative undecaprenyl-phosphate n-acetylglucosaminyl transferase (murg) family # TIGRFAMs TIGR00445 mraY # eggNOG COG0472 LUCA # eggNOG ENOG4105CPY Bacteria BLAST swissprot:MRAY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MRAY_ECOLI BioCyc ECOL316407:JW0085-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0085-MONOMER BioCyc EcoCyc:PHOSNACMURPENTATRANS-MONOMER http://biocyc.org/getid?id=EcoCyc:PHOSNACMURPENTATRANS-MONOMER BioCyc MetaCyc:PHOSNACMURPENTATRANS-MONOMER http://biocyc.org/getid?id=MetaCyc:PHOSNACMURPENTATRANS-MONOMER COG COG0472 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0472 DOI 10.1016/0005-2744(78)90355-8 http://dx.doi.org/10.1016/0005-2744(78)90355-8 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1999.01623.x http://dx.doi.org/10.1046/j.1365-2958.1999.01623.x DOI 10.1093/nar/18.4.1058 http://dx.doi.org/10.1093/nar/18.4.1058 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.8.13 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.8.13 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X51584 http://www.ebi.ac.uk/ena/data/view/X51584 EMBL X55034 http://www.ebi.ac.uk/ena/data/view/X55034 ENZYME 2.7.8.13 http://enzyme.expasy.org/EC/2.7.8.13 EchoBASE EB0599 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0599 EcoGene EG10604 http://www.ecogene.org/geneInfo.php?eg_id=EG10604 EnsemblBacteria AAC73198 http://www.ensemblgenomes.org/id/AAC73198 EnsemblBacteria AAC73198 http://www.ensemblgenomes.org/id/AAC73198 EnsemblBacteria BAB96655 http://www.ensemblgenomes.org/id/BAB96655 EnsemblBacteria BAB96655 http://www.ensemblgenomes.org/id/BAB96655 EnsemblBacteria BAB96655 http://www.ensemblgenomes.org/id/BAB96655 EnsemblBacteria b0087 http://www.ensemblgenomes.org/id/b0087 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008963 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008963 GO_function GO:0051992 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051992 GO_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0009252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009252 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 GeneID 944814 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944814 HAMAP MF_00038 http://hamap.expasy.org/unirule/MF_00038 HOGENOM HOG000275122 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275122&db=HOGENOM6 InParanoid P0A6W3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6W3 IntEnz 2.7.8.13 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.8.13 InterPro IPR000715 http://www.ebi.ac.uk/interpro/entry/IPR000715 InterPro IPR003524 http://www.ebi.ac.uk/interpro/entry/IPR003524 InterPro IPR018480 http://www.ebi.ac.uk/interpro/entry/IPR018480 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0085 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0085 KEGG_Gene eco:b0087 http://www.genome.jp/dbget-bin/www_bget?eco:b0087 KEGG_Orthology KO:K01000 http://www.genome.jp/dbget-bin/www_bget?KO:K01000 KEGG_Pathway ko00550 http://www.genome.jp/kegg-bin/show_pathway?ko00550 KEGG_Reaction rn:R05629 http://www.genome.jp/dbget-bin/www_bget?rn:R05629 KEGG_Reaction rn:R05630 http://www.genome.jp/dbget-bin/www_bget?rn:R05630 OMA HQNKKDT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HQNKKDT PANTHER PTHR22926 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22926 PROSITE PS01347 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01347 PROSITE PS01348 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01348 PSORT swissprot:MRAY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MRAY_ECOLI PSORT-B swissprot:MRAY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MRAY_ECOLI PSORT2 swissprot:MRAY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MRAY_ECOLI Pfam PF00953 http://pfam.xfam.org/family/PF00953 Pfam PF10555 http://pfam.xfam.org/family/PF10555 Phobius swissprot:MRAY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MRAY_ECOLI PhylomeDB P0A6W3 http://phylomedb.org/?seqid=P0A6W3 ProteinModelPortal P0A6W3 http://www.proteinmodelportal.org/query/uniprot/P0A6W3 PubMed 10564498 http://www.ncbi.nlm.nih.gov/pubmed/10564498 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1846850 http://www.ncbi.nlm.nih.gov/pubmed/1846850 PubMed 215212 http://www.ncbi.nlm.nih.gov/pubmed/215212 PubMed 2179861 http://www.ncbi.nlm.nih.gov/pubmed/2179861 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414629 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414629 RefSeq WP_000964131 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000964131 SMR P0A6W3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6W3 STRING 511145.b0087 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0087&targetmode=cogs STRING COG0472 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0472&targetmode=cogs TCDB 9.B.146.1 http://www.tcdb.org/search/result.php?tc=9.B.146.1 TIGRFAMs TIGR00445 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00445 UniProtKB MRAY_ECOLI http://www.uniprot.org/uniprot/MRAY_ECOLI UniProtKB-AC P0A6W3 http://www.uniprot.org/uniprot/P0A6W3 charge swissprot:MRAY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MRAY_ECOLI eggNOG COG0472 http://eggnogapi.embl.de/nog_data/html/tree/COG0472 eggNOG ENOG4105CPY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CPY epestfind swissprot:MRAY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MRAY_ECOLI garnier swissprot:MRAY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MRAY_ECOLI helixturnhelix swissprot:MRAY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MRAY_ECOLI hmoment swissprot:MRAY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MRAY_ECOLI iep swissprot:MRAY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MRAY_ECOLI inforesidue swissprot:MRAY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MRAY_ECOLI octanol swissprot:MRAY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MRAY_ECOLI pepcoil swissprot:MRAY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MRAY_ECOLI pepdigest swissprot:MRAY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MRAY_ECOLI pepinfo swissprot:MRAY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MRAY_ECOLI pepnet swissprot:MRAY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MRAY_ECOLI pepstats swissprot:MRAY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MRAY_ECOLI pepwheel swissprot:MRAY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MRAY_ECOLI pepwindow swissprot:MRAY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MRAY_ECOLI sigcleave swissprot:MRAY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MRAY_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=30.6 mM for glutamine {ECO 0000269|PubMed:18459799}; # BRENDA 3.5.1 2026 # BioGrid 4261695 6 # CATALYTIC ACTIVITY GLSA2_ECOLI L-glutamine + H(2)O = L-glutamate + NH(3). {ECO 0000255|HAMAP-Rule MF_00313, ECO 0000269|PubMed 18459799}. # EcoGene EG13816 glsA2 # GO_function GO:0004359 glutaminase activity; IDA:EcoCyc. # GO_process GO:0006537 glutamate biosynthetic process; IBA:GO_Central. # GO_process GO:0006543 glutamine catabolic process; IMP:EcoCyc. # GO_process GO:0045926 negative regulation of growth; IMP:EcoliWiki. # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.710.10 -; 1. # HAMAP MF_00313 Glutaminase # IntAct P0A6W0 3 # InterPro IPR012338 Beta-lactam/transpept-like # InterPro IPR015868 Glutaminase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00250 Alanine, aspartate and glutamate metabolism # KEGG_Pathway ko00330 Arginine and proline metabolism # KEGG_Pathway ko00471 D-Glutamine and D-glutamate metabolism # KEGG_Pathway ko00910 Nitrogen metabolism # KEGG_Pathway ko04724 Glutamatergic synapse # KEGG_Pathway ko04727 GABAergic synapse # KEGG_Pathway ko04964 Proximal tubule bicarbonate reclamation # Organism GLSA2_ECOLI Escherichia coli (strain K12) # PANTHER PTHR12544 PTHR12544 # PATRIC 32118346 VBIEscCol129921_1593 # PIR G64906 G64906 # Pfam PF04960 Glutaminase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Glutaminase 2 {ECO:0000255|HAMAP-Rule MF_00313} # RefSeq NP_416041 NC_000913.3 # RefSeq WP_000257409 NZ_LN832404.1 # SIMILARITY Belongs to the glutaminase family. {ECO:0000255|HAMAP- Rule MF_00313}. # SUBUNIT GLSA2_ECOLI Homotetramer. {ECO 0000255|HAMAP-Rule MF_00313, ECO 0000269|PubMed 18459799}. # SUPFAM SSF56601 SSF56601 # TIGRFAMs TIGR03814 Gln_ase # eggNOG COG2066 LUCA # eggNOG ENOG4105CSV Bacteria BLAST swissprot:GLSA2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLSA2_ECOLI BioCyc ECOL316407:JW1517-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1517-MONOMER BioCyc EcoCyc:G6810-MONOMER http://biocyc.org/getid?id=EcoCyc:G6810-MONOMER BioCyc MetaCyc:G6810-MONOMER http://biocyc.org/getid?id=MetaCyc:G6810-MONOMER COG COG2066 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2066 DIP DIP-12757N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12757N DOI 10.1021/bi800097h http://dx.doi.org/10.1021/bi800097h DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.5.1.2 {ECO:0000255|HAMAP-Rule:MF_00313} http://www.genome.jp/dbget-bin/www_bget?EC:3.5.1.2 {ECO:0000255|HAMAP-Rule:MF_00313} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.5.1.2 {ECO:0000255|HAMAP-Rule:MF_00313} http://enzyme.expasy.org/EC/3.5.1.2 {ECO:0000255|HAMAP-Rule:MF_00313} EchoBASE EB3577 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3577 EcoGene EG13816 http://www.ecogene.org/geneInfo.php?eg_id=EG13816 EnsemblBacteria AAC74597 http://www.ensemblgenomes.org/id/AAC74597 EnsemblBacteria AAC74597 http://www.ensemblgenomes.org/id/AAC74597 EnsemblBacteria BAA15206 http://www.ensemblgenomes.org/id/BAA15206 EnsemblBacteria BAA15206 http://www.ensemblgenomes.org/id/BAA15206 EnsemblBacteria BAA15206 http://www.ensemblgenomes.org/id/BAA15206 EnsemblBacteria b1524 http://www.ensemblgenomes.org/id/b1524 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004359 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004359 GO_process GO:0006537 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006537 GO_process GO:0006543 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006543 GO_process GO:0045926 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045926 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.710.10 http://www.cathdb.info/version/latest/superfamily/3.40.710.10 GeneID 944973 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944973 HAMAP MF_00313 http://hamap.expasy.org/unirule/MF_00313 HOGENOM HOG000216890 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000216890&db=HOGENOM6 InParanoid P0A6W0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6W0 IntAct P0A6W0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6W0* IntEnz 3.5.1.2 {ECO:0000255|HAMAP-Rule:MF_00313} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.1.2 {ECO:0000255|HAMAP-Rule:MF_00313} InterPro IPR012338 http://www.ebi.ac.uk/interpro/entry/IPR012338 InterPro IPR015868 http://www.ebi.ac.uk/interpro/entry/IPR015868 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1517 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1517 KEGG_Gene eco:b1524 http://www.genome.jp/dbget-bin/www_bget?eco:b1524 KEGG_Orthology KO:K01425 http://www.genome.jp/dbget-bin/www_bget?KO:K01425 KEGG_Pathway ko00250 http://www.genome.jp/kegg-bin/show_pathway?ko00250 KEGG_Pathway ko00330 http://www.genome.jp/kegg-bin/show_pathway?ko00330 KEGG_Pathway ko00471 http://www.genome.jp/kegg-bin/show_pathway?ko00471 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Pathway ko04724 http://www.genome.jp/kegg-bin/show_pathway?ko04724 KEGG_Pathway ko04727 http://www.genome.jp/kegg-bin/show_pathway?ko04727 KEGG_Pathway ko04964 http://www.genome.jp/kegg-bin/show_pathway?ko04964 KEGG_Reaction rn:R00256 http://www.genome.jp/dbget-bin/www_bget?rn:R00256 KEGG_Reaction rn:R01579 http://www.genome.jp/dbget-bin/www_bget?rn:R01579 OMA VNSIMAT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VNSIMAT PANTHER PTHR12544 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12544 PSORT swissprot:GLSA2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLSA2_ECOLI PSORT-B swissprot:GLSA2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLSA2_ECOLI PSORT2 swissprot:GLSA2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLSA2_ECOLI Pfam PF04960 http://pfam.xfam.org/family/PF04960 Phobius swissprot:GLSA2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLSA2_ECOLI PhylomeDB P0A6W0 http://phylomedb.org/?seqid=P0A6W0 ProteinModelPortal P0A6W0 http://www.proteinmodelportal.org/query/uniprot/P0A6W0 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18459799 http://www.ncbi.nlm.nih.gov/pubmed/18459799 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416041 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416041 RefSeq WP_000257409 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000257409 SMR P0A6W0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6W0 STRING 511145.b1524 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1524&targetmode=cogs STRING COG2066 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2066&targetmode=cogs SUPFAM SSF56601 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56601 TIGRFAMs TIGR03814 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03814 UniProtKB GLSA2_ECOLI http://www.uniprot.org/uniprot/GLSA2_ECOLI UniProtKB-AC P0A6W0 http://www.uniprot.org/uniprot/P0A6W0 charge swissprot:GLSA2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLSA2_ECOLI eggNOG COG2066 http://eggnogapi.embl.de/nog_data/html/tree/COG2066 eggNOG ENOG4105CSV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CSV epestfind swissprot:GLSA2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLSA2_ECOLI garnier swissprot:GLSA2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLSA2_ECOLI helixturnhelix swissprot:GLSA2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLSA2_ECOLI hmoment swissprot:GLSA2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLSA2_ECOLI iep swissprot:GLSA2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLSA2_ECOLI inforesidue swissprot:GLSA2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLSA2_ECOLI octanol swissprot:GLSA2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLSA2_ECOLI pepcoil swissprot:GLSA2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLSA2_ECOLI pepdigest swissprot:GLSA2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLSA2_ECOLI pepinfo swissprot:GLSA2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLSA2_ECOLI pepnet swissprot:GLSA2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLSA2_ECOLI pepstats swissprot:GLSA2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLSA2_ECOLI pepwheel swissprot:GLSA2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLSA2_ECOLI pepwindow swissprot:GLSA2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLSA2_ECOLI sigcleave swissprot:GLSA2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLSA2_ECOLI ## Database ID URL or Descriptions # BioGrid 4261574 17 # CAUTION The 21 C-terminal amino acids have been proposed to be expressed from an independent promoter within this gene and called IroK. Overexpression of IroK has been suggested to be responsible for 3-hydroxypropionic acid (3-HP) resistance. However the IroK peptide's existence has not been proven, nor has mutagenesis of HcaR itself rather than overexpression of IroK been ruled out as the cause of 3-HP resistance (PubMed:22161628). {ECO 0000305|PubMed:22161628}. # EcoGene EG13455 hcaR # FUNCTION HCAR_ECOLI Transcriptional activator of the hca operon for 3- phenylpropionic acid catabolism. # GO_function GO:0003677 DNA binding; IDA:EcoliWiki. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # IntAct Q47141 2 # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR005119 LysR_subst-bd # InterPro IPR011991 WHTH_DNA-bd_dom # KEGG_Brite ko03000 Transcription factors # Organism HCAR_ECOLI Escherichia coli (strain K12) # PATRIC 32120471 VBIEscCol129921_2638 # PIR H65030 H65030 # PRINTS PR00039 HTHLYSR # PROSITE PS50931 HTH_LYSR # Pfam PF00126 HTH_1 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HCAR_ECOLI Hca operon transcriptional activator HcaR # RefSeq NP_417032 NC_000913.3 # RefSeq WP_000423261 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lysR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00253}. # SUPFAM SSF46785 SSF46785 # eggNOG ENOG4108W5M Bacteria # eggNOG ENOG4111IYC LUCA BLAST swissprot:HCAR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HCAR_ECOLI BioCyc ECOL316407:JW2521-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2521-MONOMER BioCyc EcoCyc:G7331-MONOMER http://biocyc.org/getid?id=EcoCyc:G7331-MONOMER COG COG0583 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0583 DOI 10.1002/bit.24398 http://dx.doi.org/10.1002/bit.24398 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL Z37966 http://www.ebi.ac.uk/ena/data/view/Z37966 EchoBASE EB3228 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3228 EcoGene EG13455 http://www.ecogene.org/geneInfo.php?eg_id=EG13455 EnsemblBacteria AAC75590 http://www.ensemblgenomes.org/id/AAC75590 EnsemblBacteria AAC75590 http://www.ensemblgenomes.org/id/AAC75590 EnsemblBacteria BAA16432 http://www.ensemblgenomes.org/id/BAA16432 EnsemblBacteria BAA16432 http://www.ensemblgenomes.org/id/BAA16432 EnsemblBacteria BAA16432 http://www.ensemblgenomes.org/id/BAA16432 EnsemblBacteria b2537 http://www.ensemblgenomes.org/id/b2537 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 947000 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947000 HOGENOM HOG000233514 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000233514&db=HOGENOM6 InParanoid Q47141 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q47141 IntAct Q47141 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q47141* InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW2521 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2521 KEGG_Gene eco:b2537 http://www.genome.jp/dbget-bin/www_bget?eco:b2537 KEGG_Orthology KO:K05817 http://www.genome.jp/dbget-bin/www_bget?KO:K05817 OMA GFGRIRY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GFGRIRY PRINTS PR00039 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00039 PROSITE PS50931 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50931 PSORT swissprot:HCAR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HCAR_ECOLI PSORT-B swissprot:HCAR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HCAR_ECOLI PSORT2 swissprot:HCAR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HCAR_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:HCAR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HCAR_ECOLI PhylomeDB Q47141 http://phylomedb.org/?seqid=Q47141 ProteinModelPortal Q47141 http://www.proteinmodelportal.org/query/uniprot/Q47141 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22161628 http://www.ncbi.nlm.nih.gov/pubmed/22161628 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9603882 http://www.ncbi.nlm.nih.gov/pubmed/9603882 RefSeq NP_417032 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417032 RefSeq WP_000423261 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000423261 SMR Q47141 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q47141 STRING 511145.b2537 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2537&targetmode=cogs STRING COG0583 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0583&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB HCAR_ECOLI http://www.uniprot.org/uniprot/HCAR_ECOLI UniProtKB-AC Q47141 http://www.uniprot.org/uniprot/Q47141 charge swissprot:HCAR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HCAR_ECOLI eggNOG ENOG4108W5M http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108W5M eggNOG ENOG4111IYC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111IYC epestfind swissprot:HCAR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HCAR_ECOLI garnier swissprot:HCAR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HCAR_ECOLI helixturnhelix swissprot:HCAR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HCAR_ECOLI hmoment swissprot:HCAR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HCAR_ECOLI iep swissprot:HCAR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HCAR_ECOLI inforesidue swissprot:HCAR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HCAR_ECOLI octanol swissprot:HCAR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HCAR_ECOLI pepcoil swissprot:HCAR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HCAR_ECOLI pepdigest swissprot:HCAR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HCAR_ECOLI pepinfo swissprot:HCAR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HCAR_ECOLI pepnet swissprot:HCAR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HCAR_ECOLI pepstats swissprot:HCAR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HCAR_ECOLI pepwheel swissprot:HCAR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HCAR_ECOLI pepwindow swissprot:HCAR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HCAR_ECOLI sigcleave swissprot:HCAR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HCAR_ECOLI ## Database ID URL or Descriptions # EcoGene EG14395 yneM # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # INDUCTION YNEM_ECOLI Expressed during exponential phase (PubMed 19121005), induced by SDS/EDTA (envelope stress), at 45 degrees Celsius, repressed in minimal glucose or glycerol medium and by the thiol oxidant diamide (PubMed 19734316) (at protein level). {ECO 0000269|PubMed 19121005, ECO 0000269|PubMed 19734316}. # Organism YNEM_ECOLI Escherichia coli (strain K12) # PATRIC 32118368 VBIEscCol129921_1604 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNEM_ECOLI Uncharacterized protein YneM # RefSeq WP_000901367 NZ_LN832404.1 # RefSeq YP_001165319 NC_000913.3 # SUBCELLULAR LOCATION YNEM_ECOLI Cell inner membrane {ECO 0000305|PubMed 19121005, ECO 0000305|PubMed 21778229}; Single-pass membrane protein {ECO 0000269|PubMed 19121005, ECO 0000269|PubMed 21778229}. BLAST swissprot:YNEM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNEM_ECOLI BioCyc EcoCyc:MONOMER0-766 http://biocyc.org/getid?id=EcoCyc:MONOMER0-766 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M111.245696 http://dx.doi.org/10.1074/jbc.M111.245696 DOI 10.1111/j.1365-2958.2008.06495.x http://dx.doi.org/10.1111/j.1365-2958.2008.06495.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00872-09 http://dx.doi.org/10.1128/JB.00872-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14395 http://www.ecogene.org/geneInfo.php?eg_id=EG14395 EnsemblBacteria ABP93445 http://www.ensemblgenomes.org/id/ABP93445 EnsemblBacteria ABP93445 http://www.ensemblgenomes.org/id/ABP93445 EnsemblBacteria b4599 http://www.ensemblgenomes.org/id/b4599 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 5061497 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5061497 HOGENOM HOG000009467 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009467&db=HOGENOM6 KEGG_Gene eco:b4599 http://www.genome.jp/dbget-bin/www_bget?eco:b4599 PSORT swissprot:YNEM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNEM_ECOLI PSORT-B swissprot:YNEM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNEM_ECOLI PSORT2 swissprot:YNEM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNEM_ECOLI Phobius swissprot:YNEM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNEM_ECOLI ProteinModelPortal A5A616 http://www.proteinmodelportal.org/query/uniprot/A5A616 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19121005 http://www.ncbi.nlm.nih.gov/pubmed/19121005 PubMed 19734316 http://www.ncbi.nlm.nih.gov/pubmed/19734316 PubMed 21778229 http://www.ncbi.nlm.nih.gov/pubmed/21778229 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000901367 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000901367 RefSeq YP_001165319 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001165319 STRING 511145.b4599 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4599&targetmode=cogs UniProtKB YNEM_ECOLI http://www.uniprot.org/uniprot/YNEM_ECOLI UniProtKB-AC A5A616 http://www.uniprot.org/uniprot/A5A616 charge swissprot:YNEM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNEM_ECOLI epestfind swissprot:YNEM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNEM_ECOLI garnier swissprot:YNEM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNEM_ECOLI helixturnhelix swissprot:YNEM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNEM_ECOLI hmoment swissprot:YNEM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNEM_ECOLI iep swissprot:YNEM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNEM_ECOLI inforesidue swissprot:YNEM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNEM_ECOLI octanol swissprot:YNEM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNEM_ECOLI pepcoil swissprot:YNEM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNEM_ECOLI pepdigest swissprot:YNEM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNEM_ECOLI pepinfo swissprot:YNEM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNEM_ECOLI pepnet swissprot:YNEM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNEM_ECOLI pepstats swissprot:YNEM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNEM_ECOLI pepwheel swissprot:YNEM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNEM_ECOLI pepwindow swissprot:YNEM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNEM_ECOLI sigcleave swissprot:YNEM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNEM_ECOLI ## Database ID URL or Descriptions # BioGrid 4261150 19 # EcoGene EG12028 yeiI # GO_function GO:0016301 kinase activity; IEA:UniProtKB-KW. # GO_function GO:0016773 phosphotransferase activity, alcohol group as acceptor; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016301 kinase activity # Gene3D 1.10.10.10 -; 1. # Gene3D 3.40.1190.20 -; 1. # IntAct P33020 5 # InterPro IPR002173 Carboh/pur_kinase_PfkB_CS # InterPro IPR011611 PfkB_dom # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR029056 Ribokinase-like # Organism YEII_ECOLI Escherichia coli (strain K12) # PATRIC 32119669 VBIEscCol129921_2245 # PIR G64984 G64984 # PROSITE PS00583 PFKB_KINASES_1 # PROSITE PS00584 PFKB_KINASES_2 # Pfam PF00294 PfkB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEII_ECOLI Uncharacterized sugar kinase YeiI # RefSeq NP_416665 NC_000913.3 # RefSeq WP_001065016 NZ_LN832404.1 # SIMILARITY Belongs to the carbohydrate kinase PfkB family. {ECO 0000305}. # SUPFAM SSF46785 SSF46785 # SUPFAM SSF53613 SSF53613 # eggNOG COG0524 LUCA # eggNOG COG2771 LUCA # eggNOG ENOG4105DD7 Bacteria BLAST swissprot:YEII_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEII_ECOLI BioCyc ECOL316407:JW2147-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2147-MONOMER BioCyc EcoCyc:EG12028-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12028-MONOMER DIP DIP-11921N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11921N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M22591 http://www.ebi.ac.uk/ena/data/view/M22591 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.- http://enzyme.expasy.org/EC/2.7.1.- EchoBASE EB1963 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1963 EcoGene EG12028 http://www.ecogene.org/geneInfo.php?eg_id=EG12028 EnsemblBacteria AAC75221 http://www.ensemblgenomes.org/id/AAC75221 EnsemblBacteria AAC75221 http://www.ensemblgenomes.org/id/AAC75221 EnsemblBacteria BAE76637 http://www.ensemblgenomes.org/id/BAE76637 EnsemblBacteria BAE76637 http://www.ensemblgenomes.org/id/BAE76637 EnsemblBacteria BAE76637 http://www.ensemblgenomes.org/id/BAE76637 EnsemblBacteria b2160 http://www.ensemblgenomes.org/id/b2160 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_function GO:0016773 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016773 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 3.40.1190.20 http://www.cathdb.info/version/latest/superfamily/3.40.1190.20 GeneID 946640 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946640 HOGENOM HOG000064422 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000064422&db=HOGENOM6 InParanoid P33020 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33020 IntAct P33020 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33020* IntEnz 2.7.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1 InterPro IPR002173 http://www.ebi.ac.uk/interpro/entry/IPR002173 InterPro IPR011611 http://www.ebi.ac.uk/interpro/entry/IPR011611 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR029056 http://www.ebi.ac.uk/interpro/entry/IPR029056 KEGG_Gene ecj:JW2147 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2147 KEGG_Gene eco:b2160 http://www.genome.jp/dbget-bin/www_bget?eco:b2160 OMA GHINIAP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GHINIAP PROSITE PS00583 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00583 PROSITE PS00584 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00584 PSORT swissprot:YEII_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEII_ECOLI PSORT-B swissprot:YEII_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEII_ECOLI PSORT2 swissprot:YEII_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEII_ECOLI Pfam PF00294 http://pfam.xfam.org/family/PF00294 Phobius swissprot:YEII_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEII_ECOLI PhylomeDB P33020 http://phylomedb.org/?seqid=P33020 ProteinModelPortal P33020 http://www.proteinmodelportal.org/query/uniprot/P33020 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2460435 http://www.ncbi.nlm.nih.gov/pubmed/2460435 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416665 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416665 RefSeq WP_001065016 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001065016 SMR P33020 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33020 STRING 511145.b2160 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2160&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SUPFAM SSF53613 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53613 UniProtKB YEII_ECOLI http://www.uniprot.org/uniprot/YEII_ECOLI UniProtKB-AC P33020 http://www.uniprot.org/uniprot/P33020 charge swissprot:YEII_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEII_ECOLI eggNOG COG0524 http://eggnogapi.embl.de/nog_data/html/tree/COG0524 eggNOG COG2771 http://eggnogapi.embl.de/nog_data/html/tree/COG2771 eggNOG ENOG4105DD7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DD7 epestfind swissprot:YEII_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEII_ECOLI garnier swissprot:YEII_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEII_ECOLI helixturnhelix swissprot:YEII_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEII_ECOLI hmoment swissprot:YEII_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEII_ECOLI iep swissprot:YEII_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEII_ECOLI inforesidue swissprot:YEII_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEII_ECOLI octanol swissprot:YEII_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEII_ECOLI pepcoil swissprot:YEII_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEII_ECOLI pepdigest swissprot:YEII_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEII_ECOLI pepinfo swissprot:YEII_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEII_ECOLI pepnet swissprot:YEII_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEII_ECOLI pepstats swissprot:YEII_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEII_ECOLI pepwheel swissprot:YEII_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEII_ECOLI pepwindow swissprot:YEII_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEII_ECOLI sigcleave swissprot:YEII_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEII_ECOLI ## Database ID URL or Descriptions # BioGrid 4262535 115 # CDD cd06261 TM_PBP2 # EcoGene EG12625 dppB # FUNCTION DPPB_ECOLI Part of the binding-protein-dependent transport system for dipeptides; probably responsible for the translocation of the substrate across the membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_component GO:0016021 integral component of membrane; ISS:EcoCyc. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; ISS:EcoCyc. # GO_function GO:0022857 transmembrane transporter activity; IBA:GO_Central. # GO_process GO:0015031 protein transport; IEA:UniProtKB-KW. # GO_process GO:0015833 peptide transport; IEA:UniProtKB-KW. # GO_process GO:0055085 transmembrane transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # Gene3D 1.10.3720.10 -; 2. # IntAct P0AEF8 2 # InterPro IPR000515 MetI-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00324 Dipeptide transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism DPPB_ECOLI Escherichia coli (strain K12) # PATRIC 32122554 VBIEscCol129921_3655 # PIR S47765 S47765 # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DPPB_ECOLI Dipeptide transport system permease protein DppB # RefSeq NP_418000 NC_000913.3 # RefSeq WP_000938855 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION DPPB_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF161098 SSF161098; 2 # eggNOG COG0601 LUCA # eggNOG ENOG4105CJM Bacteria BLAST swissprot:DPPB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DPPB_ECOLI BioCyc ECOL316407:JW3512-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3512-MONOMER BioCyc EcoCyc:DPPB-MONOMER http://biocyc.org/getid?id=EcoCyc:DPPB-MONOMER BioCyc MetaCyc:DPPB-MONOMER http://biocyc.org/getid?id=MetaCyc:DPPB-MONOMER COG COG0601 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0601 DIP DIP-47927N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47927N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1111/j.1365-2958.1994.tb01340.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb01340.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L08399 http://www.ebi.ac.uk/ena/data/view/L08399 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2509 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2509 EcoGene EG12625 http://www.ecogene.org/geneInfo.php?eg_id=EG12625 EnsemblBacteria AAC76568 http://www.ensemblgenomes.org/id/AAC76568 EnsemblBacteria AAC76568 http://www.ensemblgenomes.org/id/AAC76568 EnsemblBacteria BAE77751 http://www.ensemblgenomes.org/id/BAE77751 EnsemblBacteria BAE77751 http://www.ensemblgenomes.org/id/BAE77751 EnsemblBacteria BAE77751 http://www.ensemblgenomes.org/id/BAE77751 EnsemblBacteria b3543 http://www.ensemblgenomes.org/id/b3543 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GO_process GO:0015031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031 GO_process GO:0015833 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015833 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 948063 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948063 HOGENOM HOG000170242 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000170242&db=HOGENOM6 InParanoid P0AEF8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEF8 IntAct P0AEF8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEF8* InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3512 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3512 KEGG_Gene eco:b3543 http://www.genome.jp/dbget-bin/www_bget?eco:b3543 KEGG_Orthology KO:K12369 http://www.genome.jp/dbget-bin/www_bget?KO:K12369 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 MINT MINT-1309644 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1309644 OMA ITRYTRS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ITRYTRS PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:DPPB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DPPB_ECOLI PSORT-B swissprot:DPPB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DPPB_ECOLI PSORT2 swissprot:DPPB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DPPB_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Phobius swissprot:DPPB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DPPB_ECOLI PhylomeDB P0AEF8 http://phylomedb.org/?seqid=P0AEF8 ProteinModelPortal P0AEF8 http://www.proteinmodelportal.org/query/uniprot/P0AEF8 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7536291 http://www.ncbi.nlm.nih.gov/pubmed/7536291 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418000 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418000 RefSeq WP_000938855 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000938855 STRING 511145.b3543 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3543&targetmode=cogs STRING COG0601 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0601&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 UniProtKB DPPB_ECOLI http://www.uniprot.org/uniprot/DPPB_ECOLI UniProtKB-AC P0AEF8 http://www.uniprot.org/uniprot/P0AEF8 charge swissprot:DPPB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DPPB_ECOLI eggNOG COG0601 http://eggnogapi.embl.de/nog_data/html/tree/COG0601 eggNOG ENOG4105CJM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CJM epestfind swissprot:DPPB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DPPB_ECOLI garnier swissprot:DPPB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DPPB_ECOLI helixturnhelix swissprot:DPPB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DPPB_ECOLI hmoment swissprot:DPPB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DPPB_ECOLI iep swissprot:DPPB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DPPB_ECOLI inforesidue swissprot:DPPB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DPPB_ECOLI octanol swissprot:DPPB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DPPB_ECOLI pepcoil swissprot:DPPB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DPPB_ECOLI pepdigest swissprot:DPPB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DPPB_ECOLI pepinfo swissprot:DPPB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DPPB_ECOLI pepnet swissprot:DPPB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DPPB_ECOLI pepstats swissprot:DPPB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DPPB_ECOLI pepwheel swissprot:DPPB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DPPB_ECOLI pepwindow swissprot:DPPB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DPPB_ECOLI sigcleave swissprot:DPPB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DPPB_ECOLI ## Database ID URL or Descriptions # BioGrid 4261420 15 # CATALYTIC ACTIVITY PRP2_ECOLI [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate. # COFACTOR PRP2_ECOLI Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000250}; Note=Binds 2 manganese ions per subunit. {ECO 0000250}; # EcoGene EG13102 pphB # FUNCTION PRP2_ECOLI Has been shown, in vitro, to act on Ser, Thr and Tyr- phosphorylated substrates. # GO_function GO:0008138 protein tyrosine/serine/threonine phosphatase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0043167 ion binding # Gene3D 3.60.21.10 -; 1. # IntAct P55799 5 # InterPro IPR004843 Calcineurin-like_PHP_ApaH # InterPro IPR006186 Ser/Thr-sp_prot-phosphatase # InterPro IPR029052 Metallo-depent_PP-like # KEGG_Brite ko01000 Enzymes # Organism PRP2_ECOLI Escherichia coli (strain K12) # PATRIC 32120870 VBIEscCol129921_2827 # PIR B65054 B65054 # PROSITE PS00125 SER_THR_PHOSPHATASE # Pfam PF00149 Metallophos # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PRP2_ECOLI Serine/threonine-protein phosphatase 2 # RefSeq NP_417214 NC_000913.3 # RefSeq WP_001141337 NZ_LN832404.1 # SIMILARITY Belongs to the PPP phosphatase family. {ECO 0000305}. # SUPFAM SSF56300 SSF56300 # eggNOG COG0639 LUCA # eggNOG ENOG4105MEW Bacteria BLAST swissprot:PRP2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PRP2_ECOLI BioCyc ECOL316407:JW2704-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2704-MONOMER BioCyc EcoCyc:G7415-MONOMER http://biocyc.org/getid?id=EcoCyc:G7415-MONOMER BioCyc MetaCyc:G7415-MONOMER http://biocyc.org/getid?id=MetaCyc:G7415-MONOMER COG COG0639 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0639 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/emboj/16.7.1670 http://dx.doi.org/10.1093/emboj/16.7.1670 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.3.16 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.16 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EMBL U51682 http://www.ebi.ac.uk/ena/data/view/U51682 ENZYME 3.1.3.16 http://enzyme.expasy.org/EC/3.1.3.16 EchoBASE EB2905 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2905 EcoGene EG13102 http://www.ecogene.org/geneInfo.php?eg_id=EG13102 EnsemblBacteria AAC75776 http://www.ensemblgenomes.org/id/AAC75776 EnsemblBacteria AAC75776 http://www.ensemblgenomes.org/id/AAC75776 EnsemblBacteria BAE76811 http://www.ensemblgenomes.org/id/BAE76811 EnsemblBacteria BAE76811 http://www.ensemblgenomes.org/id/BAE76811 EnsemblBacteria BAE76811 http://www.ensemblgenomes.org/id/BAE76811 EnsemblBacteria b2734 http://www.ensemblgenomes.org/id/b2734 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008138 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008138 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.60.21.10 http://www.cathdb.info/version/latest/superfamily/3.60.21.10 GeneID 947196 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947196 HOGENOM HOG000251869 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000251869&db=HOGENOM6 InParanoid P55799 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P55799 IntAct P55799 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P55799* IntEnz 3.1.3.16 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.16 InterPro IPR004843 http://www.ebi.ac.uk/interpro/entry/IPR004843 InterPro IPR006186 http://www.ebi.ac.uk/interpro/entry/IPR006186 InterPro IPR029052 http://www.ebi.ac.uk/interpro/entry/IPR029052 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2704 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2704 KEGG_Gene eco:b2734 http://www.genome.jp/dbget-bin/www_bget?eco:b2734 KEGG_Orthology KO:K07314 http://www.genome.jp/dbget-bin/www_bget?KO:K07314 OMA NTSWFIS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NTSWFIS PROSITE PS00125 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00125 PSORT swissprot:PRP2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PRP2_ECOLI PSORT-B swissprot:PRP2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PRP2_ECOLI PSORT2 swissprot:PRP2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PRP2_ECOLI Pfam PF00149 http://pfam.xfam.org/family/PF00149 Phobius swissprot:PRP2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PRP2_ECOLI PhylomeDB P55799 http://phylomedb.org/?seqid=P55799 ProteinModelPortal P55799 http://www.proteinmodelportal.org/query/uniprot/P55799 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9130712 http://www.ncbi.nlm.nih.gov/pubmed/9130712 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417214 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417214 RefSeq WP_001141337 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001141337 SMR P55799 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P55799 STRING 511145.b2734 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2734&targetmode=cogs STRING COG0639 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0639&targetmode=cogs SUPFAM SSF56300 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56300 UniProtKB PRP2_ECOLI http://www.uniprot.org/uniprot/PRP2_ECOLI UniProtKB-AC P55799 http://www.uniprot.org/uniprot/P55799 charge swissprot:PRP2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PRP2_ECOLI eggNOG COG0639 http://eggnogapi.embl.de/nog_data/html/tree/COG0639 eggNOG ENOG4105MEW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105MEW epestfind swissprot:PRP2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PRP2_ECOLI garnier swissprot:PRP2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PRP2_ECOLI helixturnhelix swissprot:PRP2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PRP2_ECOLI hmoment swissprot:PRP2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PRP2_ECOLI iep swissprot:PRP2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PRP2_ECOLI inforesidue swissprot:PRP2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PRP2_ECOLI octanol swissprot:PRP2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PRP2_ECOLI pepcoil swissprot:PRP2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PRP2_ECOLI pepdigest swissprot:PRP2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PRP2_ECOLI pepinfo swissprot:PRP2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PRP2_ECOLI pepnet swissprot:PRP2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PRP2_ECOLI pepstats swissprot:PRP2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PRP2_ECOLI pepwheel swissprot:PRP2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PRP2_ECOLI pepwindow swissprot:PRP2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PRP2_ECOLI sigcleave swissprot:PRP2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PRP2_ECOLI ## Database ID URL or Descriptions # BioGrid 4261379 266 # ESTHER ecoli-ycfp abh_upf00227 # EcoGene EG13434 ycfP # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # Gene3D 3.40.50.1820 -; 1. # HAMAP MF_01047 UPF0227 # INTERACTION YCFP_ECOLI P0A805 frr; NbExp=2; IntAct=EBI-9129402, EBI-1114349; P0A862 tpx; NbExp=3; IntAct=EBI-9129402, EBI-369411; # IntAct P0A8E1 4 # InterPro IPR008886 UPF0227/Esterase_YqiA # InterPro IPR022987 UPF0227 # InterPro IPR029058 AB_hydrolase # Organism YCFP_ECOLI Escherichia coli (strain K12) # PATRIC 32117459 VBIEscCol129921_1152 # PIR A64855 A64855 # Pfam PF05728 UPF0227 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCFP_ECOLI UPF0227 protein YcfP # RefSeq NP_415626 NC_000913.3 # RefSeq WP_000587933 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0227 family. {ECO 0000305}. # SUPFAM SSF53474 SSF53474 # eggNOG COG3150 LUCA # eggNOG ENOG4105D0Y Bacteria BLAST swissprot:YCFP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCFP_ECOLI BioCyc ECOL316407:JW5158-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5158-MONOMER BioCyc EcoCyc:G6568-MONOMER http://biocyc.org/getid?id=EcoCyc:G6568-MONOMER COG COG3150 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3150 DIP DIP-48123N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48123N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3208 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3208 EcoGene EG13434 http://www.ecogene.org/geneInfo.php?eg_id=EG13434 EnsemblBacteria AAC74192 http://www.ensemblgenomes.org/id/AAC74192 EnsemblBacteria AAC74192 http://www.ensemblgenomes.org/id/AAC74192 EnsemblBacteria BAA35915 http://www.ensemblgenomes.org/id/BAA35915 EnsemblBacteria BAA35915 http://www.ensemblgenomes.org/id/BAA35915 EnsemblBacteria BAA35915 http://www.ensemblgenomes.org/id/BAA35915 EnsemblBacteria b1108 http://www.ensemblgenomes.org/id/b1108 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 Gene3D 3.40.50.1820 http://www.cathdb.info/version/latest/superfamily/3.40.50.1820 GeneID 945676 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945676 HAMAP MF_01047 http://hamap.expasy.org/unirule/MF_01047 HOGENOM HOG000279089 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000279089&db=HOGENOM6 IntAct P0A8E1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8E1* InterPro IPR008886 http://www.ebi.ac.uk/interpro/entry/IPR008886 InterPro IPR022987 http://www.ebi.ac.uk/interpro/entry/IPR022987 InterPro IPR029058 http://www.ebi.ac.uk/interpro/entry/IPR029058 KEGG_Gene ecj:JW5158 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5158 KEGG_Gene eco:b1108 http://www.genome.jp/dbget-bin/www_bget?eco:b1108 KEGG_Orthology KO:K07000 http://www.genome.jp/dbget-bin/www_bget?KO:K07000 OMA KCVSEFR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KCVSEFR PSORT swissprot:YCFP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCFP_ECOLI PSORT-B swissprot:YCFP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCFP_ECOLI PSORT2 swissprot:YCFP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCFP_ECOLI Pfam PF05728 http://pfam.xfam.org/family/PF05728 Phobius swissprot:YCFP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCFP_ECOLI ProteinModelPortal P0A8E1 http://www.proteinmodelportal.org/query/uniprot/P0A8E1 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415626 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415626 RefSeq WP_000587933 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000587933 STRING 511145.b1108 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1108&targetmode=cogs STRING COG3150 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3150&targetmode=cogs SUPFAM SSF53474 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53474 UniProtKB YCFP_ECOLI http://www.uniprot.org/uniprot/YCFP_ECOLI UniProtKB-AC P0A8E1 http://www.uniprot.org/uniprot/P0A8E1 charge swissprot:YCFP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCFP_ECOLI eggNOG COG3150 http://eggnogapi.embl.de/nog_data/html/tree/COG3150 eggNOG ENOG4105D0Y http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D0Y epestfind swissprot:YCFP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCFP_ECOLI garnier swissprot:YCFP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCFP_ECOLI helixturnhelix swissprot:YCFP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCFP_ECOLI hmoment swissprot:YCFP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCFP_ECOLI iep swissprot:YCFP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCFP_ECOLI inforesidue swissprot:YCFP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCFP_ECOLI octanol swissprot:YCFP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCFP_ECOLI pepcoil swissprot:YCFP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCFP_ECOLI pepdigest swissprot:YCFP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCFP_ECOLI pepinfo swissprot:YCFP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCFP_ECOLI pepnet swissprot:YCFP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCFP_ECOLI pepstats swissprot:YCFP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCFP_ECOLI pepwheel swissprot:YCFP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCFP_ECOLI pepwindow swissprot:YCFP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCFP_ECOLI sigcleave swissprot:YCFP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCFP_ECOLI ## Database ID URL or Descriptions # DrugBank DB00560 Tigecycline # DrugBank DB00759 Tetracycline # EcoGene EG10918 rpsS # FUNCTION RS19_ECOLI In the E.coli 70S ribosome in the initiation state (PubMed 12809609) it has been modeled to contact the 23S rRNA of the 50S subunit forming part of bridge B1a; this bridge is broken in the model with bound EF-G. The 23S rRNA contact site in bridge B1a is modeled to differ in different ribosomal states (PubMed 12859903), contacting alternately S13 or S19. In the 3.5 angstroms resolved ribosome structures (PubMed 16272117) the contacts between L5, S13 and S19 bridge B1b are different, confirming the dynamic nature of this interaction. Bridge B1a is not visible in the crystallized ribosomes due to 23S rRNA disorder. {ECO 0000269|PubMed 12809609, ECO 0000269|PubMed 12859903, ECO 0000269|PubMed 16272117}. # FUNCTION RS19_ECOLI Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. Contacts the A site tRNA. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0022627 cytosolic small ribosomal subunit; IDA:EcoliWiki. # GO_function GO:0000049 tRNA binding; IEA:UniProtKB-KW. # GO_function GO:0003735 structural constituent of ribosome; IBA:GO_Central. # GO_function GO:0019843 rRNA binding; IEA:UniProtKB-HAMAP. # GO_process GO:0000028 ribosomal small subunit assembly; IBA:GO_Central. # GO_process GO:0006412 translation; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_function GO:0019843 rRNA binding # GOslim_process GO:0006412 translation # GOslim_process GO:0022618 ribonucleoprotein complex assembly # Gene3D 3.30.860.10 -; 1. # HAMAP MF_00531 Ribosomal_S19 # IntAct P0A7U3 30 # InterPro IPR002222 Ribosomal_S19 # InterPro IPR005732 Ribosomal_S19_bac-type # InterPro IPR020934 Ribosomal_S19_CS # InterPro IPR023575 Ribosomal_S19_SF # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 M00179 Ribosome, archaea # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=10299.6; Method=MALDI; Range=2-92; Evidence={ECO:0000269|PubMed 10094780}; # Organism RS19_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11880 PTHR11880 # PATRIC 32122064 VBIEscCol129921_3409 # PDB 1M5G Model; -; S=3-81 # PDB 2YKR EM; 9.80 A; S=3-81 # PDB 3J9Y EM; 3.90 A; s=1-92 # PDB 3J9Z EM; 3.60 A; SS=2-92 # PDB 3JA1 EM; 3.60 A; SS=2-92 # PDB 3JBU EM; 3.64 A; S=1-92 # PDB 3JBV EM; 3.32 A; S=1-92 # PDB 3JCD EM; 3.70 A; s=1-92 # PDB 3JCE EM; 3.20 A; s=1-92 # PDB 3JCJ EM; 3.70 A; z=1-92 # PDB 3JCN EM; 4.60 A; t=1-92 # PDB 4A2I EM; 16.50 A; S=3-81 # PDB 4ADV EM; 13.50 A; S=2-92 # PDB 4U1U X-ray; 2.95 A; AS/CS=3-81 # PDB 4U1V X-ray; 3.00 A; AS/CS=3-81 # PDB 4U20 X-ray; 2.90 A; AS/CS=3-81 # PDB 4U24 X-ray; 2.90 A; AS/CS=3-81 # PDB 4U25 X-ray; 2.90 A; AS/CS=3-81 # PDB 4U26 X-ray; 2.80 A; AS/CS=3-81 # PDB 4U27 X-ray; 2.80 A; AS/CS=3-81 # PDB 4V47 EM; 12.30 A; BS=2-92 # PDB 4V48 EM; 11.50 A; BS=2-92 # PDB 4V4H X-ray; 3.46 A; AS/CS=1-92 # PDB 4V4Q X-ray; 3.46 A; AS/CS=2-92 # PDB 4V4V EM; 15.00 A; AS=2-88 # PDB 4V4W EM; 15.00 A; AS=2-88 # PDB 4V50 X-ray; 3.22 A; AS/CS=2-92 # PDB 4V52 X-ray; 3.21 A; AS/CS=2-92 # PDB 4V53 X-ray; 3.54 A; AS/CS=2-92 # PDB 4V54 X-ray; 3.30 A; AS/CS=2-92 # PDB 4V55 X-ray; 4.00 A; AS/CS=2-92 # PDB 4V56 X-ray; 3.93 A; AS/CS=2-92 # PDB 4V57 X-ray; 3.50 A; AS/CS=2-92 # PDB 4V5B X-ray; 3.74 A; BS/DS=2-92 # PDB 4V5H EM; 5.80 A; AS=3-81 # PDB 4V5Y X-ray; 4.45 A; AS/CS=2-92 # PDB 4V64 X-ray; 3.50 A; AS/CS=2-92 # PDB 4V65 EM; 9.00 A; AL=1-92 # PDB 4V66 EM; 9.00 A; AL=1-92 # PDB 4V69 EM; 6.70 A; AS=3-81 # PDB 4V6C X-ray; 3.19 A; AS/CS=1-92 # PDB 4V6D X-ray; 3.81 A; AS/CS=1-92 # PDB 4V6E X-ray; 3.71 A; AS/CS=1-92 # PDB 4V6K EM; 8.25 A; BW=1-92 # PDB 4V6L EM; 13.20 A; AW=1-92 # PDB 4V6M EM; 7.10 A; AS=2-92 # PDB 4V6N EM; 12.10 A; BV=2-92 # PDB 4V6O EM; 14.70 A; AV=2-92 # PDB 4V6P EM; 13.50 A; AV=2-92 # PDB 4V6Q EM; 11.50 A; AV=2-92 # PDB 4V6R EM; 11.50 A; AV=2-92 # PDB 4V6S EM; 13.10 A; BU=2-92 # PDB 4V6T EM; 8.30 A; AS=3-81 # PDB 4V6V EM; 9.80 A; AS=2-92 # PDB 4V6Y EM; 12.00 A; AS=3-81 # PDB 4V6Z EM; 12.00 A; AS=3-81 # PDB 4V70 EM; 17.00 A; AS=3-81 # PDB 4V71 EM; 20.00 A; AS=3-81 # PDB 4V72 EM; 13.00 A; AS=3-81 # PDB 4V73 EM; 15.00 A; AS=3-81 # PDB 4V74 EM; 17.00 A; AS=3-81 # PDB 4V75 EM; 12.00 A; AS=3-81 # PDB 4V76 EM; 17.00 A; AS=3-81 # PDB 4V77 EM; 17.00 A; AS=3-81 # PDB 4V78 EM; 20.00 A; AS=3-81 # PDB 4V79 EM; 15.00 A; AS=3-81 # PDB 4V7A EM; 9.00 A; AS=3-81 # PDB 4V7B EM; 6.80 A; AS=1-92 # PDB 4V7C EM; 7.60 A; AS=2-92 # PDB 4V7D EM; 7.60 A; BS=2-92 # PDB 4V7I EM; 9.60 A; BS=1-92 # PDB 4V7S X-ray; 3.25 A; AS/CS=3-81 # PDB 4V7T X-ray; 3.19 A; AS/CS=3-81 # PDB 4V7U X-ray; 3.10 A; AS/CS=3-81 # PDB 4V7V X-ray; 3.29 A; AS/CS=3-81 # PDB 4V85 X-ray; 3.20 A; S=1-92 # PDB 4V89 X-ray; 3.70 A; AS=1-92 # PDB 4V9C X-ray; 3.30 A; AS/CS=1-92 # PDB 4V9D X-ray; 3.00 A; AS/BS=3-81 # PDB 4V9O X-ray; 2.90 A; BS/DS/FS/HS=1-92 # PDB 4V9P X-ray; 2.90 A; BS/DS/FS/HS=1-92 # PDB 4WF1 X-ray; 3.09 A; AS/CS=3-81 # PDB 4WOI X-ray; 3.00 A; AS/DS=1-92 # PDB 4WWW X-ray; 3.10 A; QS/XS=3-81 # PDB 4YBB X-ray; 2.10 A; AS/BS=3-81 # PDB 5AFI EM; 2.90 A; s=1-92 # PDB 5IQR EM; 3.00 A; x=1-92 # PDB 5IT8 X-ray; 3.12 A; AS/BS=3-81 # PDB 5J5B X-ray; 2.80 A; AS/BS=3-81 # PDB 5J7L X-ray; 3.00 A; AS/BS=3-81 # PDB 5J88 X-ray; 3.32 A; AS/BS=3-81 # PDB 5J8A X-ray; 3.10 A; AS/BS=3-81 # PDB 5J91 X-ray; 2.96 A; AS/BS=3-81 # PDB 5JC9 X-ray; 3.03 A; AS/BS=3-81 # PDB 5JTE EM; 3.60 A; AS=1-92 # PDB 5JU8 EM; 3.60 A; AS=1-92 # PDB 5KCR EM; 3.60 A; 1s=1-92 # PDB 5KCS EM; 3.90 A; 1s=1-92 # PDB 5KPS EM; 3.90 A; 24=1-92 # PDB 5KPV EM; 4.10 A; 23=1-92 # PDB 5KPW EM; 3.90 A; 23=1-92 # PDB 5KPX EM; 3.90 A; 23=1-92 # PDB 5L3P EM; 3.70 A; s=1-92 # PIR F23129 R3EC19 # PIRSF PIRSF002144 Ribosomal_S19 # PRINTS PR00975 RIBOSOMALS19 # PROSITE PS00323 RIBOSOMAL_S19 # Pfam PF00203 Ribosomal_S19 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RS19_ECOLI 30S ribosomal protein S19 # RefSeq NP_417775 NC_000913.3 # RefSeq WP_001138117 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein S19P family. {ECO 0000305}. # SUBUNIT RS19_ECOLI Part of the 30S ribosomal subunit. Binds S13 and L5 and cross-links to the A site tRNA. # SUPFAM SSF54570 SSF54570 # TIGRFAMs TIGR01050 rpsS_bact # eggNOG COG0185 LUCA BLAST swissprot:RS19_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RS19_ECOLI BioCyc ECOL316407:JW3278-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3278-MONOMER BioCyc EcoCyc:EG10918-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10918-MONOMER BioCyc MetaCyc:EG10918-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10918-MONOMER COG COG0185 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0185 DIP DIP-47904N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47904N DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1016/0014-5793(78)80180-X http://dx.doi.org/10.1016/0014-5793(78)80180-X DOI 10.1016/S0092-8674(03)00427-6 http://dx.doi.org/10.1016/S0092-8674(03)00427-6 DOI 10.1016/S0092-8674(03)00476-8 http://dx.doi.org/10.1016/S0092-8674(03)00476-8 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb841 http://dx.doi.org/10.1038/nsb841 DOI 10.1093/nar/13.12.4521 http://dx.doi.org/10.1093/nar/13.12.4521 DOI 10.1093/nar/23.22.4635 http://dx.doi.org/10.1093/nar/23.22.4635 DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1261/rna.7720204 http://dx.doi.org/10.1261/rna.7720204 DisProt DP00147 http://www.disprot.org/protein.php?id=DP00147 DrugBank DB00560 http://www.drugbank.ca/drugs/DB00560 DrugBank DB00759 http://www.drugbank.ca/drugs/DB00759 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X02613 http://www.ebi.ac.uk/ena/data/view/X02613 EchoBASE EB0911 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0911 EcoGene EG10918 http://www.ecogene.org/geneInfo.php?eg_id=EG10918 EnsemblBacteria AAC76341 http://www.ensemblgenomes.org/id/AAC76341 EnsemblBacteria AAC76341 http://www.ensemblgenomes.org/id/AAC76341 EnsemblBacteria BAE77975 http://www.ensemblgenomes.org/id/BAE77975 EnsemblBacteria BAE77975 http://www.ensemblgenomes.org/id/BAE77975 EnsemblBacteria BAE77975 http://www.ensemblgenomes.org/id/BAE77975 EnsemblBacteria b3316 http://www.ensemblgenomes.org/id/b3316 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0022627 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022627 GO_function GO:0000049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000049 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GO_process GO:0000028 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000028 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_process GO:0022618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022618 Gene3D 3.30.860.10 http://www.cathdb.info/version/latest/superfamily/3.30.860.10 GeneID 947811 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947811 HAMAP MF_00531 http://hamap.expasy.org/unirule/MF_00531 HOGENOM HOG000111560 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000111560&db=HOGENOM6 InParanoid P0A7U3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7U3 IntAct P0A7U3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7U3* InterPro IPR002222 http://www.ebi.ac.uk/interpro/entry/IPR002222 InterPro IPR005732 http://www.ebi.ac.uk/interpro/entry/IPR005732 InterPro IPR020934 http://www.ebi.ac.uk/interpro/entry/IPR020934 InterPro IPR023575 http://www.ebi.ac.uk/interpro/entry/IPR023575 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW3278 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3278 KEGG_Gene eco:b3316 http://www.genome.jp/dbget-bin/www_bget?eco:b3316 KEGG_Orthology KO:K02965 http://www.genome.jp/dbget-bin/www_bget?KO:K02965 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 OMA VHNGRQF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VHNGRQF PANTHER PTHR11880 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11880 PDB 1M5G http://www.ebi.ac.uk/pdbe-srv/view/entry/1M5G PDB 2YKR http://www.ebi.ac.uk/pdbe-srv/view/entry/2YKR PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 4A2I http://www.ebi.ac.uk/pdbe-srv/view/entry/4A2I PDB 4ADV http://www.ebi.ac.uk/pdbe-srv/view/entry/4ADV PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4V47 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V47 PDB 4V48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V48 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 1M5G http://www.ebi.ac.uk/pdbsum/1M5G PDBsum 2YKR http://www.ebi.ac.uk/pdbsum/2YKR PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 4A2I http://www.ebi.ac.uk/pdbsum/4A2I PDBsum 4ADV http://www.ebi.ac.uk/pdbsum/4ADV PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4V47 http://www.ebi.ac.uk/pdbsum/4V47 PDBsum 4V48 http://www.ebi.ac.uk/pdbsum/4V48 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PRINTS PR00975 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00975 PROSITE PS00323 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00323 PSORT swissprot:RS19_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RS19_ECOLI PSORT-B swissprot:RS19_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RS19_ECOLI PSORT2 swissprot:RS19_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RS19_ECOLI Pfam PF00203 http://pfam.xfam.org/family/PF00203 Phobius swissprot:RS19_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RS19_ECOLI PhylomeDB P0A7U3 http://phylomedb.org/?seqid=P0A7U3 ProteinModelPortal P0A7U3 http://www.proteinmodelportal.org/query/uniprot/P0A7U3 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 12244297 http://www.ncbi.nlm.nih.gov/pubmed/12244297 PubMed 12809609 http://www.ncbi.nlm.nih.gov/pubmed/12809609 PubMed 12859903 http://www.ncbi.nlm.nih.gov/pubmed/12859903 PubMed 15496525 http://www.ncbi.nlm.nih.gov/pubmed/15496525 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3279034 http://www.ncbi.nlm.nih.gov/pubmed/3279034 PubMed 348496 http://www.ncbi.nlm.nih.gov/pubmed/348496 PubMed 3892488 http://www.ncbi.nlm.nih.gov/pubmed/3892488 PubMed 8524654 http://www.ncbi.nlm.nih.gov/pubmed/8524654 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417775 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417775 RefSeq WP_001138117 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001138117 SMR P0A7U3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7U3 STRING 511145.b3316 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3316&targetmode=cogs STRING COG0185 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0185&targetmode=cogs SUPFAM SSF54570 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54570 TIGRFAMs TIGR01050 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01050 UniProtKB RS19_ECOLI http://www.uniprot.org/uniprot/RS19_ECOLI UniProtKB-AC P0A7U3 http://www.uniprot.org/uniprot/P0A7U3 charge swissprot:RS19_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RS19_ECOLI eggNOG COG0185 http://eggnogapi.embl.de/nog_data/html/tree/COG0185 epestfind swissprot:RS19_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RS19_ECOLI garnier swissprot:RS19_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RS19_ECOLI helixturnhelix swissprot:RS19_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RS19_ECOLI hmoment swissprot:RS19_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RS19_ECOLI iep swissprot:RS19_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RS19_ECOLI inforesidue swissprot:RS19_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RS19_ECOLI octanol swissprot:RS19_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RS19_ECOLI pepcoil swissprot:RS19_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RS19_ECOLI pepdigest swissprot:RS19_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RS19_ECOLI pepinfo swissprot:RS19_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RS19_ECOLI pepnet swissprot:RS19_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RS19_ECOLI pepstats swissprot:RS19_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RS19_ECOLI pepwheel swissprot:RS19_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RS19_ECOLI pepwindow swissprot:RS19_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RS19_ECOLI sigcleave swissprot:RS19_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RS19_ECOLI ## Database ID URL or Descriptions # AltName EIIAB-Man {ECO:0000303|PubMed 8262947} # AltName EIII-Man {ECO:0000303|PubMed 2951378} # AltName EIII-Man {ECO:0000303|PubMed 2951378} # AltName PTS system mannose-specific EIIA component {ECO:0000303|PubMed 8262947} # AltName PTS system mannose-specific EIIA component {ECO:0000303|PubMed 8262947} # AltName PTS system mannose-specific EIIB component {ECO:0000303|PubMed 8262947} # BioGrid 4259144 308 # CATALYTIC ACTIVITY PTNAB_ECOLI [Protein]-N(pi)-phospho-L-histidine + D- mannose(Side 1) = [protein]-L-histidine + D-mannose 6- phosphate(Side 2). {ECO 0000269|PubMed 2681202, ECO 0000269|PubMed 8262947}. # CDD cd00001 PTS_IIB_man # CDD cd00006 PTS_IIA_man # DOMAIN PTNAB_ECOLI The PTS EIIA type-4 domain is phosphorylated by phospho- HPr on a histidyl residue. Then, it transfers the phosphoryl group to the PTS EIIB type-4 domain. {ECO 0000305|PubMed 18270202, ECO 0000305|PubMed 8676384}. # DOMAIN PTNAB_ECOLI The PTS EIIB type-4 domain is phosphorylated by phospho- EIIA on a histidyl residue. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the PTS EIIC type-4 domain. {ECO 0000255|PROSITE- ProRule PRU00424, ECO 0000305|PubMed 18270202}. # EcoGene EG10567 manX # FUNCTION PTNAB_ECOLI The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (PubMed 2951378, PubMed 2999119, PubMed 2681202, PubMed 8262947). The enzyme II ManXYZ PTS system is involved in mannose transport (PubMed 2951378, PubMed 2999119, PubMed 2681202, PubMed 8262947). Also functions as a receptor for bacterial chemotaxis and is required for infection of the cell by bacteriophage lambda where it most likely functions as a pore for penetration of lambda DNA (PubMed 4604906, PubMed 353494). {ECO 0000269|PubMed 2681202, ECO 0000269|PubMed 2951378, ECO 0000269|PubMed 2999119, ECO 0000269|PubMed 353494, ECO 0000269|PubMed 4604906, ECO 0000269|PubMed 8262947}. # GO_component GO:0005737 cytoplasm; IDA:EcoCyc. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0016301 kinase activity; IDA:EcoCyc. # GO_function GO:0022870 protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity; IDA:EcoCyc. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IDA:EcoCyc. # GO_process GO:0015761 mannose transport; IDA:EcoCyc. # GO_process GO:0061490 glucose import into cell; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # Gene3D 3.40.35.10 -; 1. # Gene3D 3.40.50.510 -; 1. # INTERACTION PTNAB_ECOLI P0ACN7 cytR; NbExp=2; IntAct=EBI-554089, EBI-1125696; # IntAct P69797 14 # InterPro IPR004701 PTS_EIIA_man-typ # InterPro IPR004720 PTS_IIB_sorbose-sp # InterPro IPR013789 PTS_EIIA_man # InterPro IPR018455 PTS_IIB_sorbose-sp_subgr # InterPro IPR033887 PTS_IIA_man # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00276 PTS system, mannose-specific II component # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko00051 Fructose and mannose metabolism # KEGG_Pathway ko00520 Amino sugar and nucleotide sugar metabolism # KEGG_Pathway ko02060 Phosphotransferase system (PTS) # Organism PTNAB_ECOLI Escherichia coli (strain K12) # PATRIC 32118953 VBIEscCol129921_1894 # PDB 1PDO X-ray; 1.70 A; A=2-133 # PDB 1VRC NMR; -; A/B=1-133 # PDB 1VSQ NMR; -; A/B=2-134, C=159-323 # PDB 2JZH NMR; -; A=154-323 # PDB 2JZN NMR; -; A/B=2-134, C=159-323 # PDB 2JZO NMR; -; A/B=2-134, D=159-323 # PIR A30286 WQECM3 # PROSITE PS51096 PTS_EIIA_TYPE_4 # PROSITE PS51101 PTS_EIIB_TYPE_4 # Pfam PF03610 EIIA-man # Pfam PF03830 PTSIIB_sorb # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Mannose-specific phosphotransferase enzyme IIA component {ECO:0000303|PubMed 8262947} # RecName Mannose-specific phosphotransferase enzyme IIB component {ECO:0000303|PubMed 8262947} # RecName PTS system mannose-specific EIIAB component {ECO:0000303|PubMed 8262947} # RefSeq NP_416331 NC_000913.3 # RefSeq WP_000150543 NZ_LN832404.1 # SIMILARITY Contains 1 PTS EIIA type-4 domain. {ECO:0000255|PROSITE-ProRule PRU00419}. # SIMILARITY Contains 1 PTS EIIB type-4 domain. {ECO:0000255|PROSITE-ProRule PRU00424}. # SUBCELLULAR LOCATION PTNAB_ECOLI Cytoplasm {ECO 0000269|PubMed 16079137, ECO 0000269|PubMed 2951378, ECO 0000269|PubMed 2999119}. Cell inner membrane {ECO 0000269|PubMed 16079137, ECO 0000269|PubMed 2999119}; Peripheral membrane protein {ECO 0000269|PubMed 16079137, ECO 0000269|PubMed 2999119}. # SUBUNIT PTNAB_ECOLI Homodimer. {ECO 0000269|PubMed 15788390, ECO 0000269|PubMed 2681202, ECO 0000269|PubMed 2951378, ECO 0000269|PubMed 2999119, ECO 0000305|PubMed 8262947}. # SUPFAM SSF52728 SSF52728 # SUPFAM SSF53062 SSF53062 # TCDB 4.A.6.1 the pts mannose-fructose-sorbose (man) family # TIGRFAMs TIGR00824 EIIA-man # TIGRFAMs TIGR00854 pts-sorbose # eggNOG COG2893 LUCA # eggNOG COG3444 LUCA # eggNOG ENOG4105DAS Bacteria BLAST swissprot:PTNAB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTNAB_ECOLI BioCyc ECOL316407:JW1806-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1806-MONOMER BioCyc EcoCyc:MANX-MONOMER http://biocyc.org/getid?id=EcoCyc:MANX-MONOMER BioCyc MetaCyc:MANX-MONOMER http://biocyc.org/getid?id=MetaCyc:MANX-MONOMER COG COG3444 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3444 DIP DIP-35846N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35846N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1996.0335 http://dx.doi.org/10.1006/jmbi.1996.0335 DOI 10.1007/BF00266608 http://dx.doi.org/10.1007/BF00266608 DOI 10.1016/0014-5793(94)80138-X http://dx.doi.org/10.1016/0014-5793(94)80138-X DOI 10.1016/S0014-5793(97)00084-7 http://dx.doi.org/10.1016/S0014-5793(97)00084-7 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.71.7.2895 http://dx.doi.org/10.1073/pnas.71.7.2895 DOI 10.1074/jbc.M501986200 http://dx.doi.org/10.1074/jbc.M501986200 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1074/jbc.M800312200 http://dx.doi.org/10.1074/jbc.M800312200 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.191 {ECO:0000269|PubMed:2681202, ECO:0000269|PubMed:8262947} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.191 {ECO:0000269|PubMed:2681202, ECO:0000269|PubMed:8262947} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J02699 http://www.ebi.ac.uk/ena/data/view/J02699 EMBL M36404 http://www.ebi.ac.uk/ena/data/view/M36404 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.191 {ECO:0000269|PubMed:2681202, ECO:0000269|PubMed:8262947} http://enzyme.expasy.org/EC/2.7.1.191 {ECO:0000269|PubMed:2681202, ECO:0000269|PubMed:8262947} EchoBASE EB0562 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0562 EcoGene EG10567 http://www.ecogene.org/geneInfo.php?eg_id=EG10567 EnsemblBacteria AAC74887 http://www.ensemblgenomes.org/id/AAC74887 EnsemblBacteria AAC74887 http://www.ensemblgenomes.org/id/AAC74887 EnsemblBacteria BAA15624 http://www.ensemblgenomes.org/id/BAA15624 EnsemblBacteria BAA15624 http://www.ensemblgenomes.org/id/BAA15624 EnsemblBacteria BAA15624 http://www.ensemblgenomes.org/id/BAA15624 EnsemblBacteria b1817 http://www.ensemblgenomes.org/id/b1817 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_function GO:0022870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022870 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GO_process GO:0015761 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015761 GO_process GO:0061490 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061490 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.40.35.10 http://www.cathdb.info/version/latest/superfamily/3.40.35.10 Gene3D 3.40.50.510 http://www.cathdb.info/version/latest/superfamily/3.40.50.510 GeneID 946334 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946334 HOGENOM HOG000140047 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000140047&db=HOGENOM6 InParanoid P69797 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P69797 IntAct P69797 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69797* IntEnz 2.7.1.191 {ECO:0000269|PubMed:2681202, ECO:0000269|PubMed:8262947} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.191 {ECO:0000269|PubMed:2681202, ECO:0000269|PubMed:8262947} InterPro IPR004701 http://www.ebi.ac.uk/interpro/entry/IPR004701 InterPro IPR004720 http://www.ebi.ac.uk/interpro/entry/IPR004720 InterPro IPR013789 http://www.ebi.ac.uk/interpro/entry/IPR013789 InterPro IPR018455 http://www.ebi.ac.uk/interpro/entry/IPR018455 InterPro IPR033887 http://www.ebi.ac.uk/interpro/entry/IPR033887 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1806 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1806 KEGG_Gene eco:b1817 http://www.genome.jp/dbget-bin/www_bget?eco:b1817 KEGG_Orthology KO:K02794 http://www.genome.jp/dbget-bin/www_bget?KO:K02794 KEGG_Pathway ko00051 http://www.genome.jp/kegg-bin/show_pathway?ko00051 KEGG_Pathway ko00520 http://www.genome.jp/kegg-bin/show_pathway?ko00520 KEGG_Pathway ko02060 http://www.genome.jp/kegg-bin/show_pathway?ko02060 KEGG_Reaction rn:R02630 http://www.genome.jp/dbget-bin/www_bget?rn:R02630 MINT MINT-1228428 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1228428 OMA EMIFGKQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EMIFGKQ PDB 1PDO http://www.ebi.ac.uk/pdbe-srv/view/entry/1PDO PDB 1VRC http://www.ebi.ac.uk/pdbe-srv/view/entry/1VRC PDB 1VSQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1VSQ PDB 2JZH http://www.ebi.ac.uk/pdbe-srv/view/entry/2JZH PDB 2JZN http://www.ebi.ac.uk/pdbe-srv/view/entry/2JZN PDB 2JZO http://www.ebi.ac.uk/pdbe-srv/view/entry/2JZO PDBsum 1PDO http://www.ebi.ac.uk/pdbsum/1PDO PDBsum 1VRC http://www.ebi.ac.uk/pdbsum/1VRC PDBsum 1VSQ http://www.ebi.ac.uk/pdbsum/1VSQ PDBsum 2JZH http://www.ebi.ac.uk/pdbsum/2JZH PDBsum 2JZN http://www.ebi.ac.uk/pdbsum/2JZN PDBsum 2JZO http://www.ebi.ac.uk/pdbsum/2JZO PROSITE PS51096 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51096 PROSITE PS51101 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51101 PSORT swissprot:PTNAB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTNAB_ECOLI PSORT-B swissprot:PTNAB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTNAB_ECOLI PSORT2 swissprot:PTNAB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTNAB_ECOLI Pfam PF03610 http://pfam.xfam.org/family/PF03610 Pfam PF03830 http://pfam.xfam.org/family/PF03830 Phobius swissprot:PTNAB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTNAB_ECOLI PhylomeDB P69797 http://phylomedb.org/?seqid=P69797 ProteinModelPortal P69797 http://www.proteinmodelportal.org/query/uniprot/P69797 PubMed 15788390 http://www.ncbi.nlm.nih.gov/pubmed/15788390 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18270202 http://www.ncbi.nlm.nih.gov/pubmed/18270202 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 2681202 http://www.ncbi.nlm.nih.gov/pubmed/2681202 PubMed 2951378 http://www.ncbi.nlm.nih.gov/pubmed/2951378 PubMed 2999119 http://www.ncbi.nlm.nih.gov/pubmed/2999119 PubMed 353494 http://www.ncbi.nlm.nih.gov/pubmed/353494 PubMed 4604906 http://www.ncbi.nlm.nih.gov/pubmed/4604906 PubMed 8131846 http://www.ncbi.nlm.nih.gov/pubmed/8131846 PubMed 8262947 http://www.ncbi.nlm.nih.gov/pubmed/8262947 PubMed 8676384 http://www.ncbi.nlm.nih.gov/pubmed/8676384 PubMed 9074635 http://www.ncbi.nlm.nih.gov/pubmed/9074635 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_416331 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416331 RefSeq WP_000150543 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000150543 SMR P69797 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69797 STRING 511145.b1817 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1817&targetmode=cogs STRING COG3444 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3444&targetmode=cogs SUPFAM SSF52728 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52728 SUPFAM SSF53062 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53062 SWISS-2DPAGE P69797 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P69797 TCDB 4.A.6.1 http://www.tcdb.org/search/result.php?tc=4.A.6.1 TIGRFAMs TIGR00824 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00824 TIGRFAMs TIGR00854 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00854 UniProtKB PTNAB_ECOLI http://www.uniprot.org/uniprot/PTNAB_ECOLI UniProtKB-AC P69797 http://www.uniprot.org/uniprot/P69797 charge swissprot:PTNAB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTNAB_ECOLI eggNOG COG2893 http://eggnogapi.embl.de/nog_data/html/tree/COG2893 eggNOG COG3444 http://eggnogapi.embl.de/nog_data/html/tree/COG3444 eggNOG ENOG4105DAS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DAS epestfind swissprot:PTNAB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTNAB_ECOLI garnier swissprot:PTNAB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTNAB_ECOLI helixturnhelix swissprot:PTNAB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTNAB_ECOLI hmoment swissprot:PTNAB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTNAB_ECOLI iep swissprot:PTNAB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTNAB_ECOLI inforesidue swissprot:PTNAB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTNAB_ECOLI octanol swissprot:PTNAB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTNAB_ECOLI pepcoil swissprot:PTNAB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTNAB_ECOLI pepdigest swissprot:PTNAB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTNAB_ECOLI pepinfo swissprot:PTNAB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTNAB_ECOLI pepnet swissprot:PTNAB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTNAB_ECOLI pepstats swissprot:PTNAB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTNAB_ECOLI pepwheel swissprot:PTNAB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTNAB_ECOLI pepwindow swissprot:PTNAB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTNAB_ECOLI sigcleave swissprot:PTNAB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTNAB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260481 8 # EcoGene EG12052 ccmH # FUNCTION CCMH_ECOLI May be required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_component GO:0031237 intrinsic component of periplasmic side of plasma membrane; IDA:EcoCyc. # GO_function GO:0015035 protein disulfide oxidoreductase activity; ISM:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0017004 cytochrome complex assembly; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006461 protein complex assembly # Gene3D 1.25.40.10 -; 2. # INTERACTION CCMH_ECOLI P33927 ccmF; NbExp=3; IntAct=EBI-560309, EBI-763370; # IntAct P0ABM9 4 # InterPro IPR005616 CcmH/CycL/Ccl2/NrfF # InterPro IPR011990 TPR-like_helical_dom # InterPro IPR013026 TPR-contain_dom # InterPro IPR019734 TPR_repeat # Organism CCMH_ECOLI Escherichia coli (strain K12) # PATRIC 32119747 VBIEscCol129921_2283 # PIR H64988 H64988 # PROSITE PS50005 TPR; 2 # PROSITE PS50293 TPR_REGION # Pfam PF03918 CcmH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CCMH_ECOLI Cytochrome c-type biogenesis protein CcmH # RefSeq NP_416698 NC_000913.3 # RefSeq WP_001211575 NZ_LN832404.1 # SIMILARITY Belongs to the CcmH/CycL/Ccl2/NrfF family. {ECO 0000305}. # SIMILARITY Contains 2 TPR repeats. {ECO:0000255|PROSITE- ProRule PRU00339}. # SUBCELLULAR LOCATION CCMH_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF48452 SSF48452 # eggNOG COG3088 LUCA # eggNOG COG4235 LUCA # eggNOG ENOG4105KWW Bacteria BLAST swissprot:CCMH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CCMH_ECOLI BioCyc ECOL316407:JW2182-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2182-MONOMER BioCyc EcoCyc:EG12052-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12052-MONOMER COG COG0457 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0457 COG COG3088 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3088 DIP DIP-48146N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48146N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00008 http://www.ebi.ac.uk/ena/data/view/U00008 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1983 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1983 EcoGene EG12052 http://www.ecogene.org/geneInfo.php?eg_id=EG12052 EnsemblBacteria AAC75254 http://www.ensemblgenomes.org/id/AAC75254 EnsemblBacteria AAC75254 http://www.ensemblgenomes.org/id/AAC75254 EnsemblBacteria BAE76657 http://www.ensemblgenomes.org/id/BAE76657 EnsemblBacteria BAE76657 http://www.ensemblgenomes.org/id/BAE76657 EnsemblBacteria BAE76657 http://www.ensemblgenomes.org/id/BAE76657 EnsemblBacteria b2194 http://www.ensemblgenomes.org/id/b2194 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0031237 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031237 GO_function GO:0015035 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015035 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0017004 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017004 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 Gene3D 1.25.40.10 http://www.cathdb.info/version/latest/superfamily/1.25.40.10 GeneID 946623 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946623 HOGENOM HOG000274683 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000274683&db=HOGENOM6 IntAct P0ABM9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABM9* InterPro IPR005616 http://www.ebi.ac.uk/interpro/entry/IPR005616 InterPro IPR011990 http://www.ebi.ac.uk/interpro/entry/IPR011990 InterPro IPR013026 http://www.ebi.ac.uk/interpro/entry/IPR013026 InterPro IPR019734 http://www.ebi.ac.uk/interpro/entry/IPR019734 KEGG_Gene ecj:JW2182 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2182 KEGG_Gene eco:b2194 http://www.genome.jp/dbget-bin/www_bget?eco:b2194 KEGG_Orthology KO:K02200 http://www.genome.jp/dbget-bin/www_bget?KO:K02200 MINT MINT-225097 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-225097 OMA GYVAYLP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GYVAYLP PROSITE PS50005 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50005 PROSITE PS50293 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50293 PSORT swissprot:CCMH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CCMH_ECOLI PSORT-B swissprot:CCMH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CCMH_ECOLI PSORT2 swissprot:CCMH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CCMH_ECOLI Pfam PF03918 http://pfam.xfam.org/family/PF03918 Phobius swissprot:CCMH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CCMH_ECOLI ProteinModelPortal P0ABM9 http://www.proteinmodelportal.org/query/uniprot/P0ABM9 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7635817 http://www.ncbi.nlm.nih.gov/pubmed/7635817 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416698 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416698 RefSeq WP_001211575 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001211575 SMR P0ABM9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABM9 STRING 511145.b2194 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2194&targetmode=cogs STRING COG0457 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0457&targetmode=cogs STRING COG3088 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3088&targetmode=cogs SUPFAM SSF48452 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48452 UniProtKB CCMH_ECOLI http://www.uniprot.org/uniprot/CCMH_ECOLI UniProtKB-AC P0ABM9 http://www.uniprot.org/uniprot/P0ABM9 charge swissprot:CCMH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CCMH_ECOLI eggNOG COG3088 http://eggnogapi.embl.de/nog_data/html/tree/COG3088 eggNOG COG4235 http://eggnogapi.embl.de/nog_data/html/tree/COG4235 eggNOG ENOG4105KWW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KWW epestfind swissprot:CCMH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CCMH_ECOLI garnier swissprot:CCMH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CCMH_ECOLI helixturnhelix swissprot:CCMH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CCMH_ECOLI hmoment swissprot:CCMH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CCMH_ECOLI iep swissprot:CCMH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CCMH_ECOLI inforesidue swissprot:CCMH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CCMH_ECOLI octanol swissprot:CCMH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CCMH_ECOLI pepcoil swissprot:CCMH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CCMH_ECOLI pepdigest swissprot:CCMH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CCMH_ECOLI pepinfo swissprot:CCMH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CCMH_ECOLI pepnet swissprot:CCMH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CCMH_ECOLI pepstats swissprot:CCMH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CCMH_ECOLI pepwheel swissprot:CCMH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CCMH_ECOLI pepwindow swissprot:CCMH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CCMH_ECOLI sigcleave swissprot:CCMH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CCMH_ECOLI ## Database ID URL or Descriptions # DrugBank DB00759 Tetracycline # EcoGene EG10906 rpsG # FUNCTION RS7_ECOLI One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, where it has been shown to contact mRNA. Has been shown to contact tRNA in both the P and E sites; it probably blocks exit of the E site tRNA. {ECO 0000269|PubMed 2461734}. # FUNCTION RS7_ECOLI Protein S7 is also a translational repressor protein; it regulates the expression of the str operon members to different degrees by binding to its mRNA. {ECO 0000269|PubMed 2461734}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_component GO:0022627 cytosolic small ribosomal subunit; IDA:EcoCyc. # GO_function GO:0000049 tRNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0003729 mRNA binding; IDA:EcoCyc. # GO_function GO:0003735 structural constituent of ribosome; IBA:GO_Central. # GO_function GO:0019843 rRNA binding; IDA:EcoCyc. # GO_process GO:0000028 ribosomal small subunit assembly; IDA:EcoCyc. # GO_process GO:0006412 translation; IEA:UniProtKB-HAMAP. # GO_process GO:0017148 negative regulation of translation; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0003729 mRNA binding # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_function GO:0019843 rRNA binding # GOslim_process GO:0006412 translation # GOslim_process GO:0008150 biological_process # GOslim_process GO:0022618 ribonucleoprotein complex assembly # Gene3D 1.10.455.10 -; 1. # HAMAP MF_00480_B Ribosomal_S7_B # INTERACTION RS7_ECOLI P0A707 infC; NbExp=3; IntAct=EBI-543074, EBI-546262; P37765 rluB; NbExp=3; IntAct=EBI-543074, EBI-561550; P0A850 tig; NbExp=3; IntAct=EBI-543074, EBI-544862; # IntAct P02359 151 # InterPro IPR000235 Ribosomal_S5/S7 # InterPro IPR005717 Ribosomal_S7_bac/org-type # InterPro IPR020606 Ribosomal_S7_CS # InterPro IPR023798 Ribosomal_S7_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 M00179 Ribosome, archaea # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=19888.7; Method=MALDI; Range=2-179; Evidence={ECO:0000269|PubMed 10094780}; # MISCELLANEOUS Has been predicted to contact the N-terminal domain of IF-3 based on footprint studies; exactly how IF-3 interacts with the 30S subunit is controversial. {ECO:0000305|PubMed 11684020}. # MISCELLANEOUS RS7_ECOLI The strain K12 sequence is shown. # Organism RS7_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11205 PTHR11205 # PATRIC 32122114 VBIEscCol129921_3434 # PDB 1EG0 EM; 11.50 A; D=1-146 # PDB 1M5G Model; -; G=3-156 # PDB 1ML5 EM; 14.00 A; J=1-156 # PDB 2YKR EM; 9.80 A; G=2-152 # PDB 3J5S EM; 7.50 A; I=2-152 # PDB 3J9Y EM; 3.90 A; g=1-179 # PDB 3J9Z EM; 3.60 A; SG=2-179 # PDB 3JA1 EM; 3.60 A; SG=2-179 # PDB 3JBU EM; 3.64 A; G=1-156 # PDB 3JBV EM; 3.32 A; G=1-156 # PDB 3JCD EM; 3.70 A; g=1-179 # PDB 3JCE EM; 3.20 A; g=1-179 # PDB 3JCJ EM; 3.70 A; m=1-179 # PDB 3JCN EM; 4.60 A; h=1-179 # PDB 4A2I EM; 16.50 A; G=3-152 # PDB 4ADV EM; 13.50 A; G=2-179 # PDB 4U1U X-ray; 2.95 A; AG/CG=2-152 # PDB 4U1V X-ray; 3.00 A; AG/CG=2-152 # PDB 4U20 X-ray; 2.90 A; AG/CG=2-152 # PDB 4U24 X-ray; 2.90 A; AG/CG=2-152 # PDB 4U25 X-ray; 2.90 A; AG/CG=2-152 # PDB 4U26 X-ray; 2.80 A; AG/CG=2-152 # PDB 4U27 X-ray; 2.80 A; AG/CG=2-152 # PDB 4V47 EM; 12.30 A; BG=2-179 # PDB 4V48 EM; 11.50 A; BG=2-179 # PDB 4V4H X-ray; 3.46 A; AG/CG=1-179 # PDB 4V4Q X-ray; 3.46 A; AG/CG=2-179 # PDB 4V4V EM; 15.00 A; AG=20-156 # PDB 4V4W EM; 15.00 A; AG=20-156 # PDB 4V50 X-ray; 3.22 A; AG/CG=2-179 # PDB 4V52 X-ray; 3.21 A; AG/CG=2-179 # PDB 4V53 X-ray; 3.54 A; AG/CG=2-179 # PDB 4V54 X-ray; 3.30 A; AG/CG=2-179 # PDB 4V55 X-ray; 4.00 A; AG/CG=2-179 # PDB 4V56 X-ray; 3.93 A; AG/CG=2-179 # PDB 4V57 X-ray; 3.50 A; AG/CG=2-179 # PDB 4V5B X-ray; 3.74 A; BG/DG=2-179 # PDB 4V5H EM; 5.80 A; AG=3-152 # PDB 4V5Y X-ray; 4.45 A; AG/CG=2-179 # PDB 4V64 X-ray; 3.50 A; AG/CG=2-179 # PDB 4V65 EM; 9.00 A; AU=1-179 # PDB 4V66 EM; 9.00 A; AU=1-179 # PDB 4V69 EM; 6.70 A; AG=3-152 # PDB 4V6C X-ray; 3.19 A; AG/CG=1-179 # PDB 4V6D X-ray; 3.81 A; AG/CG=1-179 # PDB 4V6E X-ray; 3.71 A; AG/CG=1-179 # PDB 4V6K EM; 8.25 A; BK=1-179 # PDB 4V6L EM; 13.20 A; AK=1-179 # PDB 4V6M EM; 7.10 A; AG=2-179 # PDB 4V6N EM; 12.10 A; BJ=2-179 # PDB 4V6O EM; 14.70 A; AJ=2-179 # PDB 4V6P EM; 13.50 A; AJ=2-179 # PDB 4V6Q EM; 11.50 A; AJ=2-179 # PDB 4V6R EM; 11.50 A; AJ=2-179 # PDB 4V6S EM; 13.10 A; BI=2-179 # PDB 4V6T EM; 8.30 A; AG=2-152 # PDB 4V6V EM; 9.80 A; AG=2-179 # PDB 4V6Y EM; 12.00 A; AG=3-152 # PDB 4V6Z EM; 12.00 A; AG=3-152 # PDB 4V70 EM; 17.00 A; AG=3-152 # PDB 4V71 EM; 20.00 A; AG=3-152 # PDB 4V72 EM; 13.00 A; AG=3-152 # PDB 4V73 EM; 15.00 A; AG=3-152 # PDB 4V74 EM; 17.00 A; AG=3-152 # PDB 4V75 EM; 12.00 A; AG=3-152 # PDB 4V76 EM; 17.00 A; AG=3-152 # PDB 4V77 EM; 17.00 A; AG=3-152 # PDB 4V78 EM; 20.00 A; AG=3-152 # PDB 4V79 EM; 15.00 A; AG=3-152 # PDB 4V7A EM; 9.00 A; AG=3-152 # PDB 4V7B EM; 6.80 A; AG=1-179 # PDB 4V7C EM; 7.60 A; AG=2-179 # PDB 4V7D EM; 7.60 A; BG=2-179 # PDB 4V7I EM; 9.60 A; BG=1-179 # PDB 4V7S X-ray; 3.25 A; AG=2-152, CG=3-152 # PDB 4V7T X-ray; 3.19 A; AG=2-152, CG=3-152 # PDB 4V7U X-ray; 3.10 A; AG/CG=2-152 # PDB 4V7V X-ray; 3.29 A; AG=2-152, CG=3-152 # PDB 4V85 X-ray; 3.20 A; G=1-156 # PDB 4V89 X-ray; 3.70 A; AG=1-179 # PDB 4V9C X-ray; 3.30 A; AG/CG=1-179 # PDB 4V9D X-ray; 3.00 A; AG/BG=2-152 # PDB 4V9O X-ray; 2.90 A; BG/DG/FG/HG=1-179 # PDB 4V9P X-ray; 2.90 A; BG/DG/FG/HG=1-179 # PDB 4WF1 X-ray; 3.09 A; AG/CG=2-152 # PDB 4WOI X-ray; 3.00 A; AG/DG=1-179 # PDB 4WWW X-ray; 3.10 A; QG/XG=2-152 # PDB 4YBB X-ray; 2.10 A; AG/BG=2-152 # PDB 5AFI EM; 2.90 A; g=1-179 # PDB 5IQR EM; 3.00 A; l=1-179 # PDB 5IT8 X-ray; 3.12 A; AG/BG=2-152 # PDB 5J5B X-ray; 2.80 A; AG/BG=2-152 # PDB 5J7L X-ray; 3.00 A; AG/BG=2-152 # PDB 5J88 X-ray; 3.32 A; AG/BG=2-152 # PDB 5J8A X-ray; 3.10 A; AG/BG=2-152 # PDB 5J91 X-ray; 2.96 A; AG/BG=2-152 # PDB 5JC9 X-ray; 3.03 A; AG/BG=2-152 # PDB 5JTE EM; 3.60 A; AG=1-179 # PDB 5JU8 EM; 3.60 A; AG=1-179 # PDB 5KCR EM; 3.60 A; 1g=1-179 # PDB 5KCS EM; 3.90 A; 1g=1-179 # PDB 5KPS EM; 3.90 A; 12=1-179 # PDB 5KPV EM; 4.10 A; 11=1-179 # PDB 5KPW EM; 3.90 A; 11=1-179 # PDB 5KPX EM; 3.90 A; 11=1-179 # PDB 5L3P EM; 3.70 A; g=1-179 # PIR H65127 R3EC7K # PIRSF PIRSF002122 RPS7p_RPS7a_RPS5e_RPS7o # PROSITE PS00052 RIBOSOMAL_S7 # Pfam PF00177 Ribosomal_S7 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RS7_ECOLI 30S ribosomal protein S7 # RefSeq NP_417800 NC_000913.3 # RefSeq WP_001138045 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein S7P family. {ECO 0000305}. # SUBUNIT Part of the 30S ribosomal subunit. Contacts proteins S9 and S11 (By similarity). Cross-links to IF3 and the P and E site tRNAs. {ECO 0000250}. # SUPFAM SSF47973 SSF47973 # TIGRFAMs TIGR01029 rpsG_bact # eggNOG COG0049 LUCA # eggNOG ENOG4108UHY Bacteria BLAST swissprot:RS7_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RS7_ECOLI BioCyc ECOL316407:JW3303-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3303-MONOMER BioCyc EcoCyc:EG10906-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10906-MONOMER BioCyc MetaCyc:EG10906-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10906-MONOMER COG COG0049 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0049 DIP DIP-10783N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10783N DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1006/jmbi.2000.3563 http://dx.doi.org/10.1006/jmbi.2000.3563 DOI 10.1007/BF00299141 http://dx.doi.org/10.1007/BF00299141 DOI 10.1016/0378-1119(92)90014-G http://dx.doi.org/10.1016/0378-1119(92)90014-G DOI 10.1016/S0022-2836(05)80020-8 http://dx.doi.org/10.1016/S0022-2836(05)80020-8 DOI 10.1016/S0092-8674(03)00427-6 http://dx.doi.org/10.1016/S0092-8674(03)00427-6 DOI 10.1016/S0300-9084(79)80207-2 http://dx.doi.org/10.1016/S0300-9084(79)80207-2 DOI 10.1016/S1097-2765(01)00356-2 http://dx.doi.org/10.1016/S1097-2765(01)00356-2 DOI 10.1017/S1355838299991550 http://dx.doi.org/10.1017/S1355838299991550 DOI 10.1021/bi00282a020 http://dx.doi.org/10.1021/bi00282a020 DOI 10.1021/bi00418a057 http://dx.doi.org/10.1021/bi00418a057 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb841 http://dx.doi.org/10.1038/nsb841 DOI 10.1093/nar/23.22.4635 http://dx.doi.org/10.1093/nar/23.22.4635 DOI 10.1093/nar/29.3.677 http://dx.doi.org/10.1093/nar/29.3.677 DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB00759 http://www.drugbank.ca/drugs/DB00759 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01688 http://www.ebi.ac.uk/ena/data/view/J01688 EMBL J01689 http://www.ebi.ac.uk/ena/data/view/J01689 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL V00355 http://www.ebi.ac.uk/ena/data/view/V00355 EMBL X64592 http://www.ebi.ac.uk/ena/data/view/X64592 EMBL X65735 http://www.ebi.ac.uk/ena/data/view/X65735 EchoBASE EB0899 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0899 EcoGene EG10906 http://www.ecogene.org/geneInfo.php?eg_id=EG10906 EnsemblBacteria AAC76366 http://www.ensemblgenomes.org/id/AAC76366 EnsemblBacteria AAC76366 http://www.ensemblgenomes.org/id/AAC76366 EnsemblBacteria BAE77950 http://www.ensemblgenomes.org/id/BAE77950 EnsemblBacteria BAE77950 http://www.ensemblgenomes.org/id/BAE77950 EnsemblBacteria BAE77950 http://www.ensemblgenomes.org/id/BAE77950 EnsemblBacteria b3341 http://www.ensemblgenomes.org/id/b3341 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0022627 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022627 GO_function GO:0000049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000049 GO_function GO:0003729 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003729 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GO_process GO:0000028 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000028 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GO_process GO:0017148 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017148 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0003729 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003729 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0022618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022618 Gene3D 1.10.455.10 http://www.cathdb.info/version/latest/superfamily/1.10.455.10 GeneID 947846 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947846 HAMAP MF_00480_B http://hamap.expasy.org/unirule/MF_00480_B HOGENOM HOG000039067 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000039067&db=HOGENOM6 InParanoid P02359 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P02359 IntAct P02359 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P02359* InterPro IPR000235 http://www.ebi.ac.uk/interpro/entry/IPR000235 InterPro IPR005717 http://www.ebi.ac.uk/interpro/entry/IPR005717 InterPro IPR020606 http://www.ebi.ac.uk/interpro/entry/IPR020606 InterPro IPR023798 http://www.ebi.ac.uk/interpro/entry/IPR023798 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW3303 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3303 KEGG_Gene eco:b3341 http://www.genome.jp/dbget-bin/www_bget?eco:b3341 KEGG_Orthology KO:K02992 http://www.genome.jp/dbget-bin/www_bget?KO:K02992 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 MINT MINT-1236482 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1236482 OMA EVHRMAD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EVHRMAD PANTHER PTHR11205 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11205 PDB 1EG0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1EG0 PDB 1M5G http://www.ebi.ac.uk/pdbe-srv/view/entry/1M5G PDB 1ML5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ML5 PDB 2YKR http://www.ebi.ac.uk/pdbe-srv/view/entry/2YKR PDB 3J5S http://www.ebi.ac.uk/pdbe-srv/view/entry/3J5S PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 4A2I http://www.ebi.ac.uk/pdbe-srv/view/entry/4A2I PDB 4ADV http://www.ebi.ac.uk/pdbe-srv/view/entry/4ADV PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4V47 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V47 PDB 4V48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V48 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 1EG0 http://www.ebi.ac.uk/pdbsum/1EG0 PDBsum 1M5G http://www.ebi.ac.uk/pdbsum/1M5G PDBsum 1ML5 http://www.ebi.ac.uk/pdbsum/1ML5 PDBsum 2YKR http://www.ebi.ac.uk/pdbsum/2YKR PDBsum 3J5S http://www.ebi.ac.uk/pdbsum/3J5S PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 4A2I http://www.ebi.ac.uk/pdbsum/4A2I PDBsum 4ADV http://www.ebi.ac.uk/pdbsum/4ADV PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4V47 http://www.ebi.ac.uk/pdbsum/4V47 PDBsum 4V48 http://www.ebi.ac.uk/pdbsum/4V48 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PROSITE PS00052 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00052 PSORT swissprot:RS7_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RS7_ECOLI PSORT-B swissprot:RS7_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RS7_ECOLI PSORT2 swissprot:RS7_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RS7_ECOLI Pfam PF00177 http://pfam.xfam.org/family/PF00177 Phobius swissprot:RS7_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RS7_ECOLI PhylomeDB P02359 http://phylomedb.org/?seqid=P02359 ProteinModelPortal P02359 http://www.proteinmodelportal.org/query/uniprot/P02359 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 10606263 http://www.ncbi.nlm.nih.gov/pubmed/10606263 PubMed 10772857 http://www.ncbi.nlm.nih.gov/pubmed/10772857 PubMed 11160889 http://www.ncbi.nlm.nih.gov/pubmed/11160889 PubMed 11684020 http://www.ncbi.nlm.nih.gov/pubmed/11684020 PubMed 12244297 http://www.ncbi.nlm.nih.gov/pubmed/12244297 PubMed 12809609 http://www.ncbi.nlm.nih.gov/pubmed/12809609 PubMed 1398129 http://www.ncbi.nlm.nih.gov/pubmed/1398129 PubMed 1552908 http://www.ncbi.nlm.nih.gov/pubmed/1552908 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2461734 http://www.ncbi.nlm.nih.gov/pubmed/2461734 PubMed 385062 http://www.ncbi.nlm.nih.gov/pubmed/385062 PubMed 6349681 http://www.ncbi.nlm.nih.gov/pubmed/6349681 PubMed 6989816 http://www.ncbi.nlm.nih.gov/pubmed/6989816 PubMed 7000779 http://www.ncbi.nlm.nih.gov/pubmed/7000779 PubMed 7507167 http://www.ncbi.nlm.nih.gov/pubmed/7507167 PubMed 7556101 http://www.ncbi.nlm.nih.gov/pubmed/7556101 PubMed 8524654 http://www.ncbi.nlm.nih.gov/pubmed/8524654 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417800 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417800 RefSeq WP_001138045 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001138045 SMR P02359 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P02359 STRING 511145.b3341 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3341&targetmode=cogs STRING COG0049 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0049&targetmode=cogs SUPFAM SSF47973 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47973 TIGRFAMs TIGR01029 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01029 UniProtKB RS7_ECOLI http://www.uniprot.org/uniprot/RS7_ECOLI UniProtKB-AC P02359 http://www.uniprot.org/uniprot/P02359 charge swissprot:RS7_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RS7_ECOLI eggNOG COG0049 http://eggnogapi.embl.de/nog_data/html/tree/COG0049 eggNOG ENOG4108UHY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UHY epestfind swissprot:RS7_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RS7_ECOLI garnier swissprot:RS7_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RS7_ECOLI helixturnhelix swissprot:RS7_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RS7_ECOLI hmoment swissprot:RS7_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RS7_ECOLI iep swissprot:RS7_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RS7_ECOLI inforesidue swissprot:RS7_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RS7_ECOLI octanol swissprot:RS7_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RS7_ECOLI pepcoil swissprot:RS7_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RS7_ECOLI pepdigest swissprot:RS7_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RS7_ECOLI pepinfo swissprot:RS7_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RS7_ECOLI pepnet swissprot:RS7_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RS7_ECOLI pepstats swissprot:RS7_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RS7_ECOLI pepwheel swissprot:RS7_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RS7_ECOLI pepwindow swissprot:RS7_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RS7_ECOLI sigcleave swissprot:RS7_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RS7_ECOLI ## Database ID URL or Descriptions # BRENDA 1.14.99.B4 2026 # BioGrid 4261231 299 # COFACTOR Name=FAD; Xref=ChEBI:CHEBI 57692; Evidence={ECO:0000305}; # EcoGene EG13658 ubiF # FUNCTION UBIF_ECOLI Oxygenase that introduces the hydroxyl group at carbon five of 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol. # GO_function GO:0004497 monooxygenase activity; IBA:GO_Central. # GO_function GO:0008682 2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase activity; IMP:EcoliWiki. # GO_function GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; ISS:EcoCyc. # GO_function GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; IEA:InterPro. # GO_function GO:0071949 FAD binding; IEA:InterPro. # GO_process GO:0006744 ubiquinone biosynthetic process; IMP:EcoCyc. # GO_process GO:0044550 secondary metabolite biosynthetic process; IBA:GO_Central. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0019748 secondary metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.50.50.60 -; 2. # INTERACTION UBIF_ECOLI P75680 insO1; NbExp=3; IntAct=EBI-562588, EBI-9152908; # IntAct P75728 12 # InterPro IPR002938 FAD-bd # InterPro IPR010971 UbiH/COQ6 # InterPro IPR018168 Ubi_Hdrlase_CS # InterPro IPR023753 FAD/NAD-binding_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00130 Ubiquinone and other terpenoid-quinone biosynthesis # Organism UBIF_ECOLI Escherichia coli (strain K12) # PATHWAY UBIF_ECOLI Cofactor biosynthesis; ubiquinone biosynthesis. # PATRIC 32116513 VBIEscCol129921_0696 # PIR D64801 D64801 # PROSITE PS01304 UBIH # Pfam PF01494 FAD_binding_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UBIF_ECOLI 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase # RefSeq NP_415195 NC_000913.3 # RefSeq WP_000184541 NZ_LN832404.1 # SIMILARITY Belongs to the UbiH/COQ6 family. {ECO 0000305}. # SUPFAM SSF51905 SSF51905; 2 # TIGRFAMs TIGR01988 Ubi-OHases # eggNOG COG0654 LUCA # eggNOG ENOG4105EAK Bacteria BLAST swissprot:UBIF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UBIF_ECOLI BioCyc ECOL316407:JW0659-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0659-MONOMER BioCyc EcoCyc:OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-MON http://biocyc.org/getid?id=EcoCyc:OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-MON BioCyc MetaCyc:OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-MON http://biocyc.org/getid?id=MetaCyc:OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-MON COG COG0654 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0654 DIP DIP-11069N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11069N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1574-6968.2000.tb09097.x http://dx.doi.org/10.1111/j.1574-6968.2000.tb09097.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.14.13.- http://www.genome.jp/dbget-bin/www_bget?EC:1.14.13.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 ENZYME 1.14.13.- http://enzyme.expasy.org/EC/1.14.13.- EchoBASE EB3422 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3422 EcoGene EG13658 http://www.ecogene.org/geneInfo.php?eg_id=EG13658 EnsemblBacteria AAC73763 http://www.ensemblgenomes.org/id/AAC73763 EnsemblBacteria AAC73763 http://www.ensemblgenomes.org/id/AAC73763 EnsemblBacteria BAA35316 http://www.ensemblgenomes.org/id/BAA35316 EnsemblBacteria BAA35316 http://www.ensemblgenomes.org/id/BAA35316 EnsemblBacteria BAA35316 http://www.ensemblgenomes.org/id/BAA35316 EnsemblBacteria b0662 http://www.ensemblgenomes.org/id/b0662 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004497 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004497 GO_function GO:0008682 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008682 GO_function GO:0016705 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016705 GO_function GO:0016709 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016709 GO_function GO:0071949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071949 GO_process GO:0006744 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006744 GO_process GO:0044550 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044550 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0019748 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019748 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 GeneID 945261 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945261 HOGENOM HOG000255771 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000255771&db=HOGENOM6 InParanoid P75728 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75728 IntAct P75728 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75728* IntEnz 1.14.13 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.14.13 InterPro IPR002938 http://www.ebi.ac.uk/interpro/entry/IPR002938 InterPro IPR010971 http://www.ebi.ac.uk/interpro/entry/IPR010971 InterPro IPR018168 http://www.ebi.ac.uk/interpro/entry/IPR018168 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0659 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0659 KEGG_Gene eco:b0662 http://www.genome.jp/dbget-bin/www_bget?eco:b0662 KEGG_Orthology KO:K03184 http://www.genome.jp/dbget-bin/www_bget?KO:K03184 KEGG_Pathway ko00130 http://www.genome.jp/kegg-bin/show_pathway?ko00130 KEGG_Reaction rn:R06146 http://www.genome.jp/dbget-bin/www_bget?rn:R06146 KEGG_Reaction rn:R08775 http://www.genome.jp/dbget-bin/www_bget?rn:R08775 OMA TWEIEGF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TWEIEGF PROSITE PS01304 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01304 PSORT swissprot:UBIF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UBIF_ECOLI PSORT-B swissprot:UBIF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UBIF_ECOLI PSORT2 swissprot:UBIF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UBIF_ECOLI Pfam PF01494 http://pfam.xfam.org/family/PF01494 Phobius swissprot:UBIF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UBIF_ECOLI PhylomeDB P75728 http://phylomedb.org/?seqid=P75728 ProteinModelPortal P75728 http://www.proteinmodelportal.org/query/uniprot/P75728 PubMed 10802164 http://www.ncbi.nlm.nih.gov/pubmed/10802164 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415195 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415195 RefSeq WP_000184541 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000184541 SMR P75728 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75728 STRING 511145.b0662 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0662&targetmode=cogs STRING COG0654 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0654&targetmode=cogs SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 TIGRFAMs TIGR01988 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01988 UniProtKB UBIF_ECOLI http://www.uniprot.org/uniprot/UBIF_ECOLI UniProtKB-AC P75728 http://www.uniprot.org/uniprot/P75728 charge swissprot:UBIF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UBIF_ECOLI eggNOG COG0654 http://eggnogapi.embl.de/nog_data/html/tree/COG0654 eggNOG ENOG4105EAK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EAK epestfind swissprot:UBIF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UBIF_ECOLI garnier swissprot:UBIF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UBIF_ECOLI helixturnhelix swissprot:UBIF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UBIF_ECOLI hmoment swissprot:UBIF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UBIF_ECOLI iep swissprot:UBIF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UBIF_ECOLI inforesidue swissprot:UBIF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UBIF_ECOLI octanol swissprot:UBIF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UBIF_ECOLI pepcoil swissprot:UBIF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UBIF_ECOLI pepdigest swissprot:UBIF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UBIF_ECOLI pepinfo swissprot:UBIF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UBIF_ECOLI pepnet swissprot:UBIF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UBIF_ECOLI pepstats swissprot:UBIF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UBIF_ECOLI pepwheel swissprot:UBIF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UBIF_ECOLI pepwindow swissprot:UBIF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UBIF_ECOLI sigcleave swissprot:UBIF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UBIF_ECOLI ## Database ID URL or Descriptions # BRENDA 2.4.2.17 2026 # BioGrid 4263530 10 # CATALYTIC ACTIVITY 1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate. {ECO:0000269|PubMed 4909873}. # COFACTOR HIS1_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000305|PubMed 4909873}; # ENZYME REGULATION HIS1_ECOLI Feedback inhibited by histidine. Also inhibited by AMP and PR-ATP. {ECO 0000269|PubMed 14741209, ECO 0000269|PubMed 4909873}. # EcoGene EG10449 hisG # FUNCTION HIS1_ECOLI Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. {ECO 0000269|PubMed 4909873}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0003879 ATP phosphoribosyltransferase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0000105 histidine biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.30.70.120 -; 1. # HAMAP MF_00079 HisG_Long # InterPro IPR001348 ATP_PRibTrfase_HisG # InterPro IPR011322 N-reg_PII-like_a/b # InterPro IPR013115 HisG_C # InterPro IPR013820 ATP_PRibTrfase_cat # InterPro IPR015867 N-reg_PII/ATP_PRibTrfase_C # InterPro IPR018198 ATP_PRibTrfase_CS # InterPro IPR020621 ATP_PRibTrfase_HisG_long # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00340 Histidine metabolism # Organism HIS1_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21403 PTHR21403 # PATHWAY Amino-acid biosynthesis; L-histidine biosynthesis; L- histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9. {ECO 0000269|PubMed:4909873}. # PATRIC 32119373 VBIEscCol129921_2096 # PDB 1H3D X-ray; 2.70 A; A=1-299 # PDB 1Q1K X-ray; 2.90 A; A=1-299 # PIR B64967 XREC # PROSITE PS01316 ATP_P_PHORIBOSYLTR # Pfam PF01634 HisG # Pfam PF08029 HisG_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HIS1_ECOLI ATP phosphoribosyltransferase # RefSeq NP_416523 NC_000913.3 # RefSeq WP_000131782 NZ_LN832404.1 # SIMILARITY Belongs to the ATP phosphoribosyltransferase family. Long subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION HIS1_ECOLI Cytoplasm. # SUBUNIT HIS1_ECOLI Equilibrium between an active dimeric form, an inactive hexameric form and higher aggregates. Interconversion between the various forms is largely reversible and is influenced by the natural substrates and inhibitors of the enzyme. {ECO 0000269|PubMed 14741209, ECO 0000269|PubMed 4358959, ECO 0000269|PubMed 4927808}. # SUPFAM SSF54913 SSF54913 # TIGRFAMs TIGR00070 hisG # TIGRFAMs TIGR03455 HisG_C-term # UniPathway UPA00031 UER00006 # eggNOG COG0040 LUCA # eggNOG ENOG4105E21 Bacteria BLAST swissprot:HIS1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HIS1_ECOLI BioCyc ECOL316407:JW2001-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2001-MONOMER BioCyc EcoCyc:ATPPHOSRIBOSTRANS-MONOMER http://biocyc.org/getid?id=EcoCyc:ATPPHOSRIBOSTRANS-MONOMER BioCyc MetaCyc:ATPPHOSRIBOSTRANS-MONOMER http://biocyc.org/getid?id=MetaCyc:ATPPHOSRIBOSTRANS-MONOMER COG COG0040 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0040 DOI 10.1006/jmbi.1994.1384 http://dx.doi.org/10.1006/jmbi.1994.1384 DOI 10.1007/BF01943865 http://dx.doi.org/10.1007/BF01943865 DOI 10.1016/0005-2744(71)90064-7 http://dx.doi.org/10.1016/0005-2744(71)90064-7 DOI 10.1016/0022-2836(88)90194-5 http://dx.doi.org/10.1016/0022-2836(88)90194-5 DOI 10.1016/j.jmb.2003.12.020 http://dx.doi.org/10.1016/j.jmb.2003.12.020 DOI 10.1021/bi00811a025 http://dx.doi.org/10.1021/bi00811a025 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/nar/9.9.2075 http://dx.doi.org/10.1093/nar/9.9.2075 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.4.2.17 http://www.genome.jp/dbget-bin/www_bget?EC:2.4.2.17 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U02070 http://www.ebi.ac.uk/ena/data/view/U02070 EMBL V00284 http://www.ebi.ac.uk/ena/data/view/V00284 EMBL X13462 http://www.ebi.ac.uk/ena/data/view/X13462 EMBL X63697 http://www.ebi.ac.uk/ena/data/view/X63697 ENZYME 2.4.2.17 http://enzyme.expasy.org/EC/2.4.2.17 EchoBASE EB0444 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0444 EcoGene EG10449 http://www.ecogene.org/geneInfo.php?eg_id=EG10449 EnsemblBacteria AAC75080 http://www.ensemblgenomes.org/id/AAC75080 EnsemblBacteria AAC75080 http://www.ensemblgenomes.org/id/AAC75080 EnsemblBacteria BAA15850 http://www.ensemblgenomes.org/id/BAA15850 EnsemblBacteria BAA15850 http://www.ensemblgenomes.org/id/BAA15850 EnsemblBacteria BAA15850 http://www.ensemblgenomes.org/id/BAA15850 EnsemblBacteria b2019 http://www.ensemblgenomes.org/id/b2019 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0003879 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003879 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0000105 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000105 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.30.70.120 http://www.cathdb.info/version/latest/superfamily/3.30.70.120 GeneID 946549 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946549 HAMAP MF_00079 http://hamap.expasy.org/unirule/MF_00079 HOGENOM HOG000223247 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000223247&db=HOGENOM6 InParanoid P60757 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P60757 IntAct P60757 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P60757* IntEnz 2.4.2.17 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.2.17 InterPro IPR001348 http://www.ebi.ac.uk/interpro/entry/IPR001348 InterPro IPR011322 http://www.ebi.ac.uk/interpro/entry/IPR011322 InterPro IPR013115 http://www.ebi.ac.uk/interpro/entry/IPR013115 InterPro IPR013820 http://www.ebi.ac.uk/interpro/entry/IPR013820 InterPro IPR015867 http://www.ebi.ac.uk/interpro/entry/IPR015867 InterPro IPR018198 http://www.ebi.ac.uk/interpro/entry/IPR018198 InterPro IPR020621 http://www.ebi.ac.uk/interpro/entry/IPR020621 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2001 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2001 KEGG_Gene eco:b2019 http://www.genome.jp/dbget-bin/www_bget?eco:b2019 KEGG_Orthology KO:K00765 http://www.genome.jp/dbget-bin/www_bget?KO:K00765 KEGG_Pathway ko00340 http://www.genome.jp/kegg-bin/show_pathway?ko00340 KEGG_Reaction rn:R01071 http://www.genome.jp/dbget-bin/www_bget?rn:R01071 OMA YVMMDYD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YVMMDYD PANTHER PTHR21403 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21403 PDB 1H3D http://www.ebi.ac.uk/pdbe-srv/view/entry/1H3D PDB 1Q1K http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q1K PDBsum 1H3D http://www.ebi.ac.uk/pdbsum/1H3D PDBsum 1Q1K http://www.ebi.ac.uk/pdbsum/1Q1K PROSITE PS01316 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01316 PSORT swissprot:HIS1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HIS1_ECOLI PSORT-B swissprot:HIS1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HIS1_ECOLI PSORT2 swissprot:HIS1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HIS1_ECOLI Pfam PF01634 http://pfam.xfam.org/family/PF01634 Pfam PF08029 http://pfam.xfam.org/family/PF08029 Phobius swissprot:HIS1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HIS1_ECOLI PhylomeDB P60757 http://phylomedb.org/?seqid=P60757 ProteinModelPortal P60757 http://www.proteinmodelportal.org/query/uniprot/P60757 PubMed 11185885 http://www.ncbi.nlm.nih.gov/pubmed/11185885 PubMed 14741209 http://www.ncbi.nlm.nih.gov/pubmed/14741209 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3062174 http://www.ncbi.nlm.nih.gov/pubmed/3062174 PubMed 4358959 http://www.ncbi.nlm.nih.gov/pubmed/4358959 PubMed 4909873 http://www.ncbi.nlm.nih.gov/pubmed/4909873 PubMed 4927808 http://www.ncbi.nlm.nih.gov/pubmed/4927808 PubMed 6170941 http://www.ncbi.nlm.nih.gov/pubmed/6170941 PubMed 8201624 http://www.ncbi.nlm.nih.gov/pubmed/8201624 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416523 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416523 RefSeq WP_000131782 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000131782 SMR P60757 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P60757 STRING 511145.b2019 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2019&targetmode=cogs STRING COG0040 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0040&targetmode=cogs SUPFAM SSF54913 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54913 SWISS-2DPAGE P60757 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P60757 TIGRFAMs TIGR00070 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00070 TIGRFAMs TIGR03455 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03455 UniProtKB HIS1_ECOLI http://www.uniprot.org/uniprot/HIS1_ECOLI UniProtKB-AC P60757 http://www.uniprot.org/uniprot/P60757 charge swissprot:HIS1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HIS1_ECOLI eggNOG COG0040 http://eggnogapi.embl.de/nog_data/html/tree/COG0040 eggNOG ENOG4105E21 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E21 epestfind swissprot:HIS1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HIS1_ECOLI garnier swissprot:HIS1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HIS1_ECOLI helixturnhelix swissprot:HIS1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HIS1_ECOLI hmoment swissprot:HIS1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HIS1_ECOLI iep swissprot:HIS1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HIS1_ECOLI inforesidue swissprot:HIS1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HIS1_ECOLI octanol swissprot:HIS1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HIS1_ECOLI pepcoil swissprot:HIS1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HIS1_ECOLI pepdigest swissprot:HIS1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HIS1_ECOLI pepinfo swissprot:HIS1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HIS1_ECOLI pepnet swissprot:HIS1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HIS1_ECOLI pepstats swissprot:HIS1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HIS1_ECOLI pepwheel swissprot:HIS1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HIS1_ECOLI pepwindow swissprot:HIS1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HIS1_ECOLI sigcleave swissprot:HIS1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HIS1_ECOLI ## Database ID URL or Descriptions # AltName ATP-polyphosphate phosphotransferase {ECO:0000255|HAMAP-Rule MF_00347} # AltName Polyphosphoric acid kinase {ECO:0000255|HAMAP-Rule MF_00347} # BRENDA 2.7.4 2026 # BioGrid 4261066 17 # CATALYTIC ACTIVITY PPK_ECOLI ATP + (phosphate)(n) = ADP + (phosphate)(n+1). {ECO 0000255|HAMAP-Rule MF_00347, ECO 0000269|PubMed 10660553, ECO 0000269|PubMed 1331061, ECO 0000269|PubMed 8962061}. # COFACTOR PPK_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_00347, ECO 0000269|PubMed 10660553}; # EcoGene EG11510 ppk # FUNCTION PPK_ECOLI Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Can form linear polymers of orthophosphate with chain lengths up to 1000 or more. Can use GTP instead of ATP, but the efficiency of GTP is 5% that of ATP. Also exhibits several other enzymatic activities, which include ATP synthesis from polyP in the presence of excess ADP, general nucleoside-diphosphate kinase activity, linear guanosine 5'-tetraphosphate (ppppG) synthesis and autophosphorylation. {ECO 0000269|PubMed 10660553, ECO 0000269|PubMed 8962061}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0009358 polyphosphate kinase complex; IDA:EcoCyc. # GO_component GO:0031241 periplasmic side of cell outer membrane; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0008976 polyphosphate kinase activity; IDA:EcoCyc. # GO_function GO:0016776 phosphotransferase activity, phosphate group as acceptor; IDA:EcoCyc. # GO_function GO:0016778 diphosphotransferase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function PPK_ECOLI GO 0043751 polyphosphate AMP phosphotransferase activity; IMP EcoCyc. # GO_process GO:0006757 ATP generation from ADP; IDA:EcoCyc. # GO_process GO:0006799 polyphosphate biosynthetic process; IDA:EcoCyc. # GO_process GO:0046777 protein autophosphorylation; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.30.1840.10 -; 1. # HAMAP MF_00347 Polyphosphate_kinase # IntAct P0A7B1 29 # InterPro IPR001736 PLipase_D/transphosphatidylase # InterPro IPR003414 PP_kinase # InterPro IPR024953 PP_kinase_middle # InterPro IPR025198 PPK_N_dom # InterPro IPR025200 PPK_C_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00190 Oxidative phosphorylation # KEGG_Pathway ko03018 RNA degradation # Organism PPK_ECOLI Escherichia coli (strain K12) # PATRIC 32120391 VBIEscCol129921_2598 # PDB 1XDO X-ray; 3.00 A; A/B=2-688 # PDB 1XDP X-ray; 2.50 A; A/B=2-688 # PIR A44306 A44306 # PIRSF PIRSF015589 PP_kinase # PROSITE PS50035 PLD # PTM PPK_ECOLI An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond. {ECO 0000255|HAMAP-Rule MF_00347, ECO 0000269|PubMed 8962061}. # Pfam PF02503 PP_kinase # Pfam PF13089 PP_kinase_N # Pfam PF13090 PP_kinase_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Polyphosphate kinase {ECO:0000255|HAMAP-Rule MF_00347} # RefSeq NP_416996 NC_000913.3 # RefSeq WP_000529576 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA83900.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the polyphosphate kinase family. {ECO:0000255|HAMAP-Rule MF_00347}. # SIMILARITY Contains 1 PLD phosphodiesterase domain. {ECO:0000255|HAMAP-Rule MF_00347}. # SUBCELLULAR LOCATION PPK_ECOLI Cell membrane {ECO 0000269|PubMed 1331061}; Peripheral membrane protein {ECO 0000269|PubMed 1331061}. Note=Associated with the outer membrane in overproducing cells. {ECO 0000269|PubMed 1331061}. # SUBUNIT PPK_ECOLI Homotetramer (PubMed 1331061). Dimer of dimers (PubMed 10660553, PubMed 15947782). The diverse functions of this enzyme involve different subunit organizations and conformations (PubMed 10660553). {ECO 0000269|PubMed 10660553, ECO 0000269|PubMed 1331061, ECO 0000269|PubMed 15947782}. # SUPFAM SSF140356 SSF140356 # TIGRFAMs TIGR03705 poly_P_kin # eggNOG COG0855 LUCA # eggNOG ENOG4105CUU Bacteria BLAST swissprot:PPK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PPK_ECOLI BioCyc ECOL316407:JW2486-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2486-MONOMER BioCyc EcoCyc:PPK-MONOMER http://biocyc.org/getid?id=EcoCyc:PPK-MONOMER BioCyc MetaCyc:PPK-MONOMER http://biocyc.org/getid?id=MetaCyc:PPK-MONOMER COG COG0855 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0855 DIP DIP-36218N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36218N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/sj.embor.7400448 http://dx.doi.org/10.1038/sj.embor.7400448 DOI 10.1073/pnas.93.25.14391 http://dx.doi.org/10.1073/pnas.93.25.14391 DOI 10.1074/jbc.275.6.3977 http://dx.doi.org/10.1074/jbc.275.6.3977 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.4.1 {ECO:0000255|HAMAP-Rule:MF_00347, ECO:0000269|PubMed:10660553, ECO:0000269|PubMed:1331061, ECO:0000269|PubMed:8962061} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.4.1 {ECO:0000255|HAMAP-Rule:MF_00347, ECO:0000269|PubMed:10660553, ECO:0000269|PubMed:1331061, ECO:0000269|PubMed:8962061} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L03719 http://www.ebi.ac.uk/ena/data/view/L03719 EMBL L06129 http://www.ebi.ac.uk/ena/data/view/L06129 EMBL M13747 http://www.ebi.ac.uk/ena/data/view/M13747 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.4.1 {ECO:0000255|HAMAP-Rule:MF_00347, ECO:0000269|PubMed:10660553, ECO:0000269|PubMed:1331061, ECO:0000269|PubMed:8962061} http://enzyme.expasy.org/EC/2.7.4.1 {ECO:0000255|HAMAP-Rule:MF_00347, ECO:0000269|PubMed:10660553, ECO:0000269|PubMed:1331061, ECO:0000269|PubMed:8962061} EchoBASE EB1472 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1472 EcoGene EG11510 http://www.ecogene.org/geneInfo.php?eg_id=EG11510 EnsemblBacteria AAC75554 http://www.ensemblgenomes.org/id/AAC75554 EnsemblBacteria AAC75554 http://www.ensemblgenomes.org/id/AAC75554 EnsemblBacteria BAA16389 http://www.ensemblgenomes.org/id/BAA16389 EnsemblBacteria BAA16389 http://www.ensemblgenomes.org/id/BAA16389 EnsemblBacteria BAA16389 http://www.ensemblgenomes.org/id/BAA16389 EnsemblBacteria b2501 http://www.ensemblgenomes.org/id/b2501 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0009358 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009358 GO_component GO:0031241 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031241 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008976 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008976 GO_function GO:0016776 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016776 GO_function GO:0016778 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016778 GO_function GO:0043751 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043751 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006757 GO_process GO:0006799 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006799 GO_process GO:0046777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046777 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.30.1840.10 http://www.cathdb.info/version/latest/superfamily/3.30.1840.10 GeneID 946971 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946971 HAMAP MF_00347 http://hamap.expasy.org/unirule/MF_00347 HOGENOM HOG000248949 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000248949&db=HOGENOM6 InParanoid P0A7B1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7B1 IntAct P0A7B1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7B1* IntEnz 2.7.4.1 {ECO:0000255|HAMAP-Rule:MF_00347, ECO:0000269|PubMed:10660553, ECO:0000269|PubMed:1331061, ECO:0000269|PubMed:8962061} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.4.1 {ECO:0000255|HAMAP-Rule:MF_00347, ECO:0000269|PubMed:10660553, ECO:0000269|PubMed:1331061, ECO:0000269|PubMed:8962061} InterPro IPR001736 http://www.ebi.ac.uk/interpro/entry/IPR001736 InterPro IPR003414 http://www.ebi.ac.uk/interpro/entry/IPR003414 InterPro IPR024953 http://www.ebi.ac.uk/interpro/entry/IPR024953 InterPro IPR025198 http://www.ebi.ac.uk/interpro/entry/IPR025198 InterPro IPR025200 http://www.ebi.ac.uk/interpro/entry/IPR025200 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2486 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2486 KEGG_Gene eco:b2501 http://www.genome.jp/dbget-bin/www_bget?eco:b2501 KEGG_Orthology KO:K00937 http://www.genome.jp/dbget-bin/www_bget?KO:K00937 KEGG_Pathway ko00190 http://www.genome.jp/kegg-bin/show_pathway?ko00190 KEGG_Pathway ko03018 http://www.genome.jp/kegg-bin/show_pathway?ko03018 MINT MINT-1244108 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1244108 OMA LSSMIHA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LSSMIHA PDB 1XDO http://www.ebi.ac.uk/pdbe-srv/view/entry/1XDO PDB 1XDP http://www.ebi.ac.uk/pdbe-srv/view/entry/1XDP PDBsum 1XDO http://www.ebi.ac.uk/pdbsum/1XDO PDBsum 1XDP http://www.ebi.ac.uk/pdbsum/1XDP PROSITE PS50035 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50035 PSORT swissprot:PPK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PPK_ECOLI PSORT-B swissprot:PPK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PPK_ECOLI PSORT2 swissprot:PPK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PPK_ECOLI Pfam PF02503 http://pfam.xfam.org/family/PF02503 Pfam PF13089 http://pfam.xfam.org/family/PF13089 Pfam PF13090 http://pfam.xfam.org/family/PF13090 Phobius swissprot:PPK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PPK_ECOLI PhylomeDB P0A7B1 http://phylomedb.org/?seqid=P0A7B1 ProteinModelPortal P0A7B1 http://www.proteinmodelportal.org/query/uniprot/P0A7B1 PubMed 10660553 http://www.ncbi.nlm.nih.gov/pubmed/10660553 PubMed 1331061 http://www.ncbi.nlm.nih.gov/pubmed/1331061 PubMed 15947782 http://www.ncbi.nlm.nih.gov/pubmed/15947782 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3301838 http://www.ncbi.nlm.nih.gov/pubmed/3301838 PubMed 8380170 http://www.ncbi.nlm.nih.gov/pubmed/8380170 PubMed 8962061 http://www.ncbi.nlm.nih.gov/pubmed/8962061 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416996 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416996 RefSeq WP_000529576 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000529576 SMR P0A7B1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7B1 STRING 511145.b2501 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2501&targetmode=cogs STRING COG0855 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0855&targetmode=cogs SUPFAM SSF140356 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF140356 TIGRFAMs TIGR03705 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03705 UniProtKB PPK_ECOLI http://www.uniprot.org/uniprot/PPK_ECOLI UniProtKB-AC P0A7B1 http://www.uniprot.org/uniprot/P0A7B1 charge swissprot:PPK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PPK_ECOLI eggNOG COG0855 http://eggnogapi.embl.de/nog_data/html/tree/COG0855 eggNOG ENOG4105CUU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CUU epestfind swissprot:PPK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PPK_ECOLI garnier swissprot:PPK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PPK_ECOLI helixturnhelix swissprot:PPK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PPK_ECOLI hmoment swissprot:PPK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PPK_ECOLI iep swissprot:PPK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PPK_ECOLI inforesidue swissprot:PPK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PPK_ECOLI octanol swissprot:PPK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PPK_ECOLI pepcoil swissprot:PPK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PPK_ECOLI pepdigest swissprot:PPK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PPK_ECOLI pepinfo swissprot:PPK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PPK_ECOLI pepnet swissprot:PPK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PPK_ECOLI pepstats swissprot:PPK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PPK_ECOLI pepwheel swissprot:PPK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PPK_ECOLI pepwindow swissprot:PPK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PPK_ECOLI sigcleave swissprot:PPK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PPK_ECOLI ## Database ID URL or Descriptions # BioGrid 4260537 49 # EcoGene EG14130 yfdF # Organism YFDF_ECOLI Escherichia coli (strain K12) # PATRIC 32120063 VBIEscCol129921_2441 # PIR G65007 G65007 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFDF_ECOLI Uncharacterized protein YfdF # RefSeq NP_416847 NC_000913.3 # RefSeq WP_000937788 NZ_LN832404.1 BLAST swissprot:YFDF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFDF_ECOLI BioCyc ECOL316407:JW2342-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2342-MONOMER BioCyc EcoCyc:G7215-MONOMER http://biocyc.org/getid?id=EcoCyc:G7215-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3882 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3882 EcoGene EG14130 http://www.ecogene.org/geneInfo.php?eg_id=EG14130 EnsemblBacteria AAC75405 http://www.ensemblgenomes.org/id/AAC75405 EnsemblBacteria AAC75405 http://www.ensemblgenomes.org/id/AAC75405 EnsemblBacteria BAE76693 http://www.ensemblgenomes.org/id/BAE76693 EnsemblBacteria BAE76693 http://www.ensemblgenomes.org/id/BAE76693 EnsemblBacteria BAE76693 http://www.ensemblgenomes.org/id/BAE76693 EnsemblBacteria b2345 http://www.ensemblgenomes.org/id/b2345 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946819 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946819 HOGENOM HOG000009518 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009518&db=HOGENOM6 IntAct P76505 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76505* KEGG_Gene ecj:JW2342 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2342 KEGG_Gene eco:b2345 http://www.genome.jp/dbget-bin/www_bget?eco:b2345 OMA PDRFNIN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PDRFNIN PSORT swissprot:YFDF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFDF_ECOLI PSORT-B swissprot:YFDF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFDF_ECOLI PSORT2 swissprot:YFDF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFDF_ECOLI Phobius swissprot:YFDF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFDF_ECOLI ProteinModelPortal P76505 http://www.proteinmodelportal.org/query/uniprot/P76505 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416847 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416847 RefSeq WP_000937788 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000937788 STRING 511145.b2345 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2345&targetmode=cogs UniProtKB YFDF_ECOLI http://www.uniprot.org/uniprot/YFDF_ECOLI UniProtKB-AC P76505 http://www.uniprot.org/uniprot/P76505 charge swissprot:YFDF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFDF_ECOLI epestfind swissprot:YFDF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFDF_ECOLI garnier swissprot:YFDF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFDF_ECOLI helixturnhelix swissprot:YFDF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFDF_ECOLI hmoment swissprot:YFDF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFDF_ECOLI iep swissprot:YFDF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFDF_ECOLI inforesidue swissprot:YFDF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFDF_ECOLI octanol swissprot:YFDF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFDF_ECOLI pepcoil swissprot:YFDF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFDF_ECOLI pepdigest swissprot:YFDF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFDF_ECOLI pepinfo swissprot:YFDF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFDF_ECOLI pepnet swissprot:YFDF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFDF_ECOLI pepstats swissprot:YFDF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFDF_ECOLI pepwheel swissprot:YFDF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFDF_ECOLI pepwindow swissprot:YFDF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFDF_ECOLI sigcleave swissprot:YFDF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFDF_ECOLI ## Database ID URL or Descriptions # BioGrid 4261275 37 # DISRUPTION PHENOTYPE Deletion mutants grow faster and have higher viabilities in rich media, but have lower viabilities than the wild type in the late stationary phase. {ECO:0000269|PubMed 22534295}. # EcoGene EG12796 ibaG # FUNCTION IBAG_ECOLI Involved in cell resistance against acid stress. {ECO 0000269|PubMed 22534295}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # Gene3D 3.30.300.90 -; 1. # INDUCTION Induced by acidic stress during exponential phase. {ECO:0000269|PubMed 22534295}. # IntAct P0A9W6 2 # InterPro IPR002634 BolA # Organism IBAG_ECOLI Escherichia coli (strain K12) # PATRIC 32121800 VBIEscCol129921_3284 # PDB 1NY8 NMR; -; A=1-84 # PIRSF PIRSF003113 BolA # Pfam PF01722 BolA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Acid stress protein IbaG {ECO 0000305} # RefSeq NP_417657 NC_000913.3 # RefSeq WP_000429656 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA57991.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the BolA/IbaG family. {ECO 0000305}. # SUPFAM SSF82657 SSF82657 # eggNOG COG5007 LUCA # eggNOG ENOG4105VFK Bacteria BLAST swissprot:IBAG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:IBAG_ECOLI BioCyc ECOL316407:JW3157-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3157-MONOMER BioCyc EcoCyc:G7657-MONOMER http://biocyc.org/getid?id=EcoCyc:G7657-MONOMER DIP DIP-48231N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48231N DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2648 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2648 EcoGene EG12796 http://www.ecogene.org/geneInfo.php?eg_id=EG12796 EnsemblBacteria AAC76222 http://www.ensemblgenomes.org/id/AAC76222 EnsemblBacteria AAC76222 http://www.ensemblgenomes.org/id/AAC76222 EnsemblBacteria BAE77234 http://www.ensemblgenomes.org/id/BAE77234 EnsemblBacteria BAE77234 http://www.ensemblgenomes.org/id/BAE77234 EnsemblBacteria BAE77234 http://www.ensemblgenomes.org/id/BAE77234 EnsemblBacteria b3190 http://www.ensemblgenomes.org/id/b3190 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 Gene3D 3.30.300.90 http://www.cathdb.info/version/latest/superfamily/3.30.300.90 GeneID 947958 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947958 HOGENOM HOG000255170 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000255170&db=HOGENOM6 InParanoid P0A9W6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9W6 IntAct P0A9W6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9W6* InterPro IPR002634 http://www.ebi.ac.uk/interpro/entry/IPR002634 KEGG_Gene ecj:JW3157 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3157 KEGG_Gene eco:b3190 http://www.genome.jp/dbget-bin/www_bget?eco:b3190 OMA TINAFTP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TINAFTP PDB 1NY8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1NY8 PDBsum 1NY8 http://www.ebi.ac.uk/pdbsum/1NY8 PSORT swissprot:IBAG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:IBAG_ECOLI PSORT-B swissprot:IBAG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:IBAG_ECOLI PSORT2 swissprot:IBAG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:IBAG_ECOLI Pfam PF01722 http://pfam.xfam.org/family/PF01722 Phobius swissprot:IBAG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:IBAG_ECOLI PhylomeDB P0A9W6 http://phylomedb.org/?seqid=P0A9W6 ProteinModelPortal P0A9W6 http://www.proteinmodelportal.org/query/uniprot/P0A9W6 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22534295 http://www.ncbi.nlm.nih.gov/pubmed/22534295 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417657 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417657 RefSeq WP_000429656 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000429656 SMR P0A9W6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9W6 STRING 511145.b3190 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3190&targetmode=cogs SUPFAM SSF82657 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF82657 UniProtKB IBAG_ECOLI http://www.uniprot.org/uniprot/IBAG_ECOLI UniProtKB-AC P0A9W6 http://www.uniprot.org/uniprot/P0A9W6 charge swissprot:IBAG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:IBAG_ECOLI eggNOG COG5007 http://eggnogapi.embl.de/nog_data/html/tree/COG5007 eggNOG ENOG4105VFK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VFK epestfind swissprot:IBAG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:IBAG_ECOLI garnier swissprot:IBAG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:IBAG_ECOLI helixturnhelix swissprot:IBAG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:IBAG_ECOLI hmoment swissprot:IBAG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:IBAG_ECOLI iep swissprot:IBAG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:IBAG_ECOLI inforesidue swissprot:IBAG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:IBAG_ECOLI octanol swissprot:IBAG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:IBAG_ECOLI pepcoil swissprot:IBAG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:IBAG_ECOLI pepdigest swissprot:IBAG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:IBAG_ECOLI pepinfo swissprot:IBAG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:IBAG_ECOLI pepnet swissprot:IBAG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:IBAG_ECOLI pepstats swissprot:IBAG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:IBAG_ECOLI pepwheel swissprot:IBAG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:IBAG_ECOLI pepwindow swissprot:IBAG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:IBAG_ECOLI sigcleave swissprot:IBAG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:IBAG_ECOLI ## Database ID URL or Descriptions # BioGrid 4261481 3 # EcoGene EG14429 yicS # IntAct Q2M7X4 5 # Organism YICS_ECOLI Escherichia coli (strain K12) # PATRIC 32122815 VBIEscCol129921_3783 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YICS_ECOLI Uncharacterized protein YicS # RefSeq WP_000805509 NZ_LN832404.1 # RefSeq YP_588471 NC_000913.3 # eggNOG ENOG4105T8A Bacteria # eggNOG ENOG4111WZH LUCA BLAST swissprot:YICS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YICS_ECOLI BioCyc ECOL316407:JW5965-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5965-MONOMER BioCyc EcoCyc:MONOMER0-2691 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2691 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14429 http://www.ecogene.org/geneInfo.php?eg_id=EG14429 EnsemblBacteria ABD18705 http://www.ensemblgenomes.org/id/ABD18705 EnsemblBacteria ABD18705 http://www.ensemblgenomes.org/id/ABD18705 EnsemblBacteria BAE77632 http://www.ensemblgenomes.org/id/BAE77632 EnsemblBacteria BAE77632 http://www.ensemblgenomes.org/id/BAE77632 EnsemblBacteria BAE77632 http://www.ensemblgenomes.org/id/BAE77632 EnsemblBacteria b4555 http://www.ensemblgenomes.org/id/b4555 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1450300 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1450300 HOGENOM HOG000126271 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126271&db=HOGENOM6 IntAct Q2M7X4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q2M7X4* KEGG_Gene ecj:JW5965 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5965 KEGG_Gene eco:b4555 http://www.genome.jp/dbget-bin/www_bget?eco:b4555 OMA ERNNQNN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ERNNQNN PSORT swissprot:YICS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YICS_ECOLI PSORT-B swissprot:YICS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YICS_ECOLI PSORT2 swissprot:YICS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YICS_ECOLI Phobius swissprot:YICS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YICS_ECOLI ProteinModelPortal Q2M7X4 http://www.proteinmodelportal.org/query/uniprot/Q2M7X4 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000805509 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000805509 RefSeq YP_588471 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_588471 STRING 511145.b4555 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4555&targetmode=cogs UniProtKB YICS_ECOLI http://www.uniprot.org/uniprot/YICS_ECOLI UniProtKB-AC Q2M7X4 http://www.uniprot.org/uniprot/Q2M7X4 charge swissprot:YICS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YICS_ECOLI eggNOG ENOG4105T8A http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105T8A eggNOG ENOG4111WZH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111WZH epestfind swissprot:YICS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YICS_ECOLI garnier swissprot:YICS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YICS_ECOLI helixturnhelix swissprot:YICS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YICS_ECOLI hmoment swissprot:YICS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YICS_ECOLI iep swissprot:YICS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YICS_ECOLI inforesidue swissprot:YICS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YICS_ECOLI octanol swissprot:YICS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YICS_ECOLI pepcoil swissprot:YICS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YICS_ECOLI pepdigest swissprot:YICS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YICS_ECOLI pepinfo swissprot:YICS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YICS_ECOLI pepnet swissprot:YICS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YICS_ECOLI pepstats swissprot:YICS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YICS_ECOLI pepwheel swissprot:YICS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YICS_ECOLI pepwindow swissprot:YICS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YICS_ECOLI sigcleave swissprot:YICS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YICS_ECOLI ## Database ID URL or Descriptions # BioGrid 4259379 56 # EcoGene EG10312 fimE # FUNCTION FIME_ECOLI FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_process GO:0006310 DNA recombination; IMP:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0015074 DNA integration; IMP:EcoCyc. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.443.10 -; 1. # InterPro IPR002104 Integrase_catalytic # InterPro IPR011010 DNA_brk_join_enz # InterPro IPR013762 Integrase-like_cat # Organism FIME_ECOLI Escherichia coli (strain K12) # PATRIC 32124222 VBIEscCol129921_4454 # PIR B25111 RGECFE # Pfam PF00589 Phage_integrase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FIME_ECOLI Type 1 fimbriae regulatory protein FimE # RefSeq NP_418733 NC_000913.3 # RefSeq WP_000044711 NZ_LN832404.1 # SIMILARITY Belongs to the 'phage' integrase family. {ECO 0000305}. # SUPFAM SSF56349 SSF56349 # eggNOG COG0582 LUCA # eggNOG ENOG4105E71 Bacteria BLAST swissprot:FIME_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FIME_ECOLI BioCyc ECOL316407:JW4276-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4276-MONOMER BioCyc EcoCyc:EG10312-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10312-MONOMER COG COG0582 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0582 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X03923 http://www.ebi.ac.uk/ena/data/view/X03923 EchoBASE EB0308 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0308 EcoGene EG10312 http://www.ecogene.org/geneInfo.php?eg_id=EG10312 EnsemblBacteria AAC77269 http://www.ensemblgenomes.org/id/AAC77269 EnsemblBacteria AAC77269 http://www.ensemblgenomes.org/id/AAC77269 EnsemblBacteria BAE78306 http://www.ensemblgenomes.org/id/BAE78306 EnsemblBacteria BAE78306 http://www.ensemblgenomes.org/id/BAE78306 EnsemblBacteria BAE78306 http://www.ensemblgenomes.org/id/BAE78306 EnsemblBacteria b4313 http://www.ensemblgenomes.org/id/b4313 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0015074 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015074 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.443.10 http://www.cathdb.info/version/latest/superfamily/1.10.443.10 GeneID 948836 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948836 HOGENOM HOG000117333 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117333&db=HOGENOM6 InParanoid P0ADH7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADH7 IntAct P0ADH7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADH7* InterPro IPR002104 http://www.ebi.ac.uk/interpro/entry/IPR002104 InterPro IPR011010 http://www.ebi.ac.uk/interpro/entry/IPR011010 InterPro IPR013762 http://www.ebi.ac.uk/interpro/entry/IPR013762 KEGG_Gene ecj:JW4276 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4276 KEGG_Gene eco:b4313 http://www.genome.jp/dbget-bin/www_bget?eco:b4313 KEGG_Orthology KO:K07358 http://www.genome.jp/dbget-bin/www_bget?KO:K07358 OMA KRDYLFF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KRDYLFF PSORT swissprot:FIME_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FIME_ECOLI PSORT-B swissprot:FIME_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FIME_ECOLI PSORT2 swissprot:FIME_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FIME_ECOLI Pfam PF00589 http://pfam.xfam.org/family/PF00589 Phobius swissprot:FIME_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FIME_ECOLI PhylomeDB P0ADH7 http://phylomedb.org/?seqid=P0ADH7 ProteinModelPortal P0ADH7 http://www.proteinmodelportal.org/query/uniprot/P0ADH7 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2874022 http://www.ncbi.nlm.nih.gov/pubmed/2874022 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418733 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418733 RefSeq WP_000044711 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000044711 SMR P0ADH7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADH7 STRING 511145.b4313 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4313&targetmode=cogs STRING COG0582 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0582&targetmode=cogs SUPFAM SSF56349 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56349 UniProtKB FIME_ECOLI http://www.uniprot.org/uniprot/FIME_ECOLI UniProtKB-AC P0ADH7 http://www.uniprot.org/uniprot/P0ADH7 charge swissprot:FIME_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FIME_ECOLI eggNOG COG0582 http://eggnogapi.embl.de/nog_data/html/tree/COG0582 eggNOG ENOG4105E71 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E71 epestfind swissprot:FIME_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FIME_ECOLI garnier swissprot:FIME_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FIME_ECOLI helixturnhelix swissprot:FIME_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FIME_ECOLI hmoment swissprot:FIME_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FIME_ECOLI iep swissprot:FIME_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FIME_ECOLI inforesidue swissprot:FIME_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FIME_ECOLI octanol swissprot:FIME_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FIME_ECOLI pepcoil swissprot:FIME_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FIME_ECOLI pepdigest swissprot:FIME_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FIME_ECOLI pepinfo swissprot:FIME_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FIME_ECOLI pepnet swissprot:FIME_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FIME_ECOLI pepstats swissprot:FIME_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FIME_ECOLI pepwheel swissprot:FIME_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FIME_ECOLI pepwindow swissprot:FIME_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FIME_ECOLI sigcleave swissprot:FIME_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FIME_ECOLI ## Database ID URL or Descriptions # BioGrid 4263195 16 # CATALYTIC ACTIVITY PGMB_ECOLI Beta-D-glucose 1-phosphate = beta-D-glucose 6- phosphate. # COFACTOR PGMB_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 15808744}; Note=Binds 2 magnesium ions per subunit. {ECO 0000269|PubMed 15808744}; # DISRUPTION PHENOTYPE Cells lacking this gene are only slightly more susceptible to nalidixic acid, but are more sensitive to UV irradiation than the wild-type. {ECO:0000269|PubMed 20128927}. # EcoGene EG13918 ycjU # FUNCTION PGMB_ECOLI Catalyzes the interconversion of D-glucose 1-phosphate (G1P) and D-glucose 6-phosphate (G6P), forming beta-D-glucose 1,6- (bis)phosphate (beta-G16P) as an intermediate. The beta- phosphoglucomutase (Beta-PGM) acts on the beta-C(1) anomer of G1P. Glucose or lactose are used in preference to maltose, which is only utilized after glucose or lactose has been exhausted. It plays a key role in the regulation of the flow of carbohydrate intermediates in glycolysis and the formation of the sugar nucleotide UDP-glucose. {ECO 0000269|PubMed 15808744}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0000287 magnesium ion binding; IDA:UniProtKB. # GO_function GO:0008801 beta-phosphoglucomutase activity; IDA:EcoCyc. # GO_function GO:0016791 phosphatase activity; IBA:GO_Central. # GO_process GO:0005975 carbohydrate metabolic process; ISS:UniProtKB. # GO_process GO:0006974 cellular response to DNA damage stimulus; IMP:EcoCyc. # GO_process GO:0009294 DNA mediated transformation; IMP:EcoCyc. # GO_process GO:0046677 response to antibiotic; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # Gene3D 1.10.150.240 -; 1. # Gene3D 3.40.50.1000 -; 2. # InterPro IPR006439 HAD-SF_hydro_IA # InterPro IPR010972 Beta-phosphoglucomutase # InterPro IPR010976 B-phosphoglucomutase_hydrolase # InterPro IPR023198 PGP_dom2 # InterPro IPR023214 HAD-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00500 Starch and sucrose metabolism # MISCELLANEOUS The catalysis proceeds via a phosphoenzyme formed by reaction of an active-site nucleophile with the cofactor glucose 1,6-diphosphate (G1,6-diP). The phosphorylated mutase binds either G1P or G6P and transfers the phosphoryl group to the C(6)OH or C(1)OH, respectively (By similarity). {ECO 0000250}. # Organism PGMB_ECOLI Escherichia coli (strain K12) # PATRIC 32117906 VBIEscCol129921_1373 # PDB 4G9B X-ray; 1.70 A; A=1-219 # PIR H64880 H64880 # PRINTS PR00413 HADHALOGNASE # PTM PGMB_ECOLI Autophosphorylated. {ECO 0000250}. # Pfam PF13419 HAD_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PGMB_ECOLI Beta-phosphoglucomutase # RefSeq NP_415833 NC_000913.3 # RefSeq WP_000775794 NZ_LN832404.1 # SIMILARITY Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. {ECO 0000305}. # SUBCELLULAR LOCATION PGMB_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Monomer. {ECO 0000250}. # SUPFAM SSF56784 SSF56784 # TIGRFAMs TIGR01509 HAD-SF-IA-v3 # TIGRFAMs TIGR01990 bPGM # TIGRFAMs TIGR02009 PGMB-YQAB-SF # eggNOG COG0637 LUCA # eggNOG ENOG4107URF Bacteria BLAST swissprot:PGMB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PGMB_ECOLI BioCyc ECOL316407:JW1310-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1310-MONOMER BioCyc EcoCyc:G6655-MONOMER http://biocyc.org/getid?id=EcoCyc:G6655-MONOMER BioCyc MetaCyc:G6655-MONOMER http://biocyc.org/getid?id=MetaCyc:G6655-MONOMER COG COG0637 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0637 DOI 10.1016/j.fmrre.2004.12.006 http://dx.doi.org/10.1016/j.fmrre.2004.12.006 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1186/1471-2180-10-35 http://dx.doi.org/10.1186/1471-2180-10-35 EC_number EC:5.4.2.6 http://www.genome.jp/dbget-bin/www_bget?EC:5.4.2.6 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 5.4.2.6 http://enzyme.expasy.org/EC/5.4.2.6 EchoBASE EB3677 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3677 EcoGene EG13918 http://www.ecogene.org/geneInfo.php?eg_id=EG13918 EnsemblBacteria AAC74399 http://www.ensemblgenomes.org/id/AAC74399 EnsemblBacteria AAC74399 http://www.ensemblgenomes.org/id/AAC74399 EnsemblBacteria BAA14892 http://www.ensemblgenomes.org/id/BAA14892 EnsemblBacteria BAA14892 http://www.ensemblgenomes.org/id/BAA14892 EnsemblBacteria BAA14892 http://www.ensemblgenomes.org/id/BAA14892 EnsemblBacteria b1317 http://www.ensemblgenomes.org/id/b1317 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0008801 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008801 GO_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0009294 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009294 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.10.150.240 http://www.cathdb.info/version/latest/superfamily/1.10.150.240 Gene3D 3.40.50.1000 http://www.cathdb.info/version/latest/superfamily/3.40.50.1000 GeneID 945891 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945891 HOGENOM HOG000248341 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000248341&db=HOGENOM6 InParanoid P77366 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77366 IntAct P77366 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77366* IntEnz 5.4.2.6 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.4.2.6 InterPro IPR006439 http://www.ebi.ac.uk/interpro/entry/IPR006439 InterPro IPR010972 http://www.ebi.ac.uk/interpro/entry/IPR010972 InterPro IPR010976 http://www.ebi.ac.uk/interpro/entry/IPR010976 InterPro IPR023198 http://www.ebi.ac.uk/interpro/entry/IPR023198 InterPro IPR023214 http://www.ebi.ac.uk/interpro/entry/IPR023214 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1310 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1310 KEGG_Gene eco:b1317 http://www.genome.jp/dbget-bin/www_bget?eco:b1317 KEGG_Orthology KO:K01838 http://www.genome.jp/dbget-bin/www_bget?KO:K01838 KEGG_Pathway ko00500 http://www.genome.jp/kegg-bin/show_pathway?ko00500 KEGG_Reaction rn:R02728 http://www.genome.jp/dbget-bin/www_bget?rn:R02728 OMA KYHYLAW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KYHYLAW PDB 4G9B http://www.ebi.ac.uk/pdbe-srv/view/entry/4G9B PDBsum 4G9B http://www.ebi.ac.uk/pdbsum/4G9B PRINTS PR00413 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00413 PSORT swissprot:PGMB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PGMB_ECOLI PSORT-B swissprot:PGMB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PGMB_ECOLI PSORT2 swissprot:PGMB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PGMB_ECOLI Pfam PF13419 http://pfam.xfam.org/family/PF13419 Phobius swissprot:PGMB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PGMB_ECOLI PhylomeDB P77366 http://phylomedb.org/?seqid=P77366 ProteinModelPortal P77366 http://www.proteinmodelportal.org/query/uniprot/P77366 PubMed 15808744 http://www.ncbi.nlm.nih.gov/pubmed/15808744 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20128927 http://www.ncbi.nlm.nih.gov/pubmed/20128927 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415833 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415833 RefSeq WP_000775794 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000775794 SMR P77366 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77366 STRING 511145.b1317 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1317&targetmode=cogs STRING COG0637 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0637&targetmode=cogs SUPFAM SSF56784 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784 TIGRFAMs TIGR01509 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01509 TIGRFAMs TIGR01990 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01990 TIGRFAMs TIGR02009 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02009 UniProtKB PGMB_ECOLI http://www.uniprot.org/uniprot/PGMB_ECOLI UniProtKB-AC P77366 http://www.uniprot.org/uniprot/P77366 charge swissprot:PGMB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PGMB_ECOLI eggNOG COG0637 http://eggnogapi.embl.de/nog_data/html/tree/COG0637 eggNOG ENOG4107URF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107URF epestfind swissprot:PGMB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PGMB_ECOLI garnier swissprot:PGMB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PGMB_ECOLI helixturnhelix swissprot:PGMB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PGMB_ECOLI hmoment swissprot:PGMB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PGMB_ECOLI iep swissprot:PGMB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PGMB_ECOLI inforesidue swissprot:PGMB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PGMB_ECOLI octanol swissprot:PGMB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PGMB_ECOLI pepcoil swissprot:PGMB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PGMB_ECOLI pepdigest swissprot:PGMB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PGMB_ECOLI pepinfo swissprot:PGMB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PGMB_ECOLI pepnet swissprot:PGMB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PGMB_ECOLI pepstats swissprot:PGMB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PGMB_ECOLI pepwheel swissprot:PGMB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PGMB_ECOLI pepwindow swissprot:PGMB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PGMB_ECOLI sigcleave swissprot:PGMB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PGMB_ECOLI ## Database ID URL or Descriptions # BioGrid 4262719 8 # CATALYTIC ACTIVITY A 3'-ribonucleotide + H(2)O = a ribonucleoside + phosphate. {ECO:0000269|PubMed 3005231}. # CATALYTIC ACTIVITY Nucleoside 2',3'-cyclic phosphate + H(2)O = nucleoside 3'-phosphate. {ECO:0000269|PubMed 3005231}. # COFACTOR Name=a divalent metal cation; Xref=ChEBI:CHEBI 60240; Evidence={ECO:0000250}; # EcoGene EG10160 cpdB # FUNCTION CPDB_ECOLI This bifunctional enzyme catalyzes two consecutive reactions during ribonucleic acid degradation. Converts a 2',3'- cyclic nucleotide to a 3'-nucleotide and then the 3'-nucleotide to the corresponding nucleoside and phosphate. {ECO 0000269|PubMed 3005231}. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_component GO:0042597 periplasmic space; IDA:EcoCyc. # GO_function GO:0000166 nucleotide binding; IEA:UniProtKB-KW. # GO_function GO:0008254 3'-nucleotidase activity; IDA:EcoCyc. # GO_function GO:0008663 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0009166 nucleotide catabolic process; IEP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.60.21.10 -; 1. # Gene3D 3.90.780.10 -; 1. # IntAct P08331 2 # InterPro IPR004843 Calcineurin-like_PHP_ApaH # InterPro IPR006146 5'-Nucleotdase_CS # InterPro IPR006179 5_nucleotidase/apyrase # InterPro IPR006294 Cyc_nuc_PDE_nucleotidase # InterPro IPR008334 5'-Nucleotdase_C # InterPro IPR029052 Metallo-depent_PP-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00240 Pyrimidine metabolism # MISCELLANEOUS CPDB_ECOLI Two kinetically distinguishable active sites for the two substrates (2',3'-cyclic nucleotides and 3'-nucleotides) have been identified. # Organism CPDB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11575 PTHR11575 # PATRIC 32124001 VBIEscCol129921_4345 # PIR H65232 ESECPC # PRINTS PR01607 APYRASEFAMLY # PROSITE PS00785 5_NUCLEOTIDASE_1 # PROSITE PS00786 5_NUCLEOTIDASE_2 # Pfam PF00149 Metallophos # Pfam PF02872 5_nucleotid_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CPDB_ECOLI 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase # RefSeq NP_418634 NC_000913.3 # RefSeq WP_000589431 NZ_LN832404.1 # SIMILARITY Belongs to the 5'-nucleotidase family. {ECO 0000305}. # SUBCELLULAR LOCATION CPDB_ECOLI Periplasm {ECO 0000269|PubMed 3005231}. # SUPFAM SSF55816 SSF55816 # SUPFAM SSF56300 SSF56300 # TIGRFAMs TIGR01390 CycNucDiestase # eggNOG COG0737 LUCA # eggNOG ENOG4107RNS Bacteria BLAST swissprot:CPDB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CPDB_ECOLI BioCyc ECOL316407:JW4171-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4171-MONOMER BioCyc EcoCyc:CPDB-MONOMER http://biocyc.org/getid?id=EcoCyc:CPDB-MONOMER BioCyc MetaCyc:CPDB-MONOMER http://biocyc.org/getid?id=MetaCyc:CPDB-MONOMER COG COG0737 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0737 DIP DIP-9311N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9311N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.3.6 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.6 EC_number EC:3.1.4.16 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.4.16 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M13464 http://www.ebi.ac.uk/ena/data/view/M13464 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X54008 http://www.ebi.ac.uk/ena/data/view/X54008 ENZYME 3.1.3.6 http://enzyme.expasy.org/EC/3.1.3.6 ENZYME 3.1.4.16 http://enzyme.expasy.org/EC/3.1.4.16 EchoBASE EB0158 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0158 EcoGene EG10160 http://www.ecogene.org/geneInfo.php?eg_id=EG10160 EnsemblBacteria AAC77170 http://www.ensemblgenomes.org/id/AAC77170 EnsemblBacteria AAC77170 http://www.ensemblgenomes.org/id/AAC77170 EnsemblBacteria BAE78214 http://www.ensemblgenomes.org/id/BAE78214 EnsemblBacteria BAE78214 http://www.ensemblgenomes.org/id/BAE78214 EnsemblBacteria BAE78214 http://www.ensemblgenomes.org/id/BAE78214 EnsemblBacteria b4213 http://www.ensemblgenomes.org/id/b4213 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0000166 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000166 GO_function GO:0008254 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008254 GO_function GO:0008663 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008663 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0009166 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009166 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.60.21.10 http://www.cathdb.info/version/latest/superfamily/3.60.21.10 Gene3D 3.90.780.10 http://www.cathdb.info/version/latest/superfamily/3.90.780.10 GeneID 948729 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948729 HOGENOM HOG000248800 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000248800&db=HOGENOM6 InParanoid P08331 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P08331 IntAct P08331 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P08331* IntEnz 3.1.3.6 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.6 IntEnz 3.1.4.16 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.4.16 InterPro IPR004843 http://www.ebi.ac.uk/interpro/entry/IPR004843 InterPro IPR006146 http://www.ebi.ac.uk/interpro/entry/IPR006146 InterPro IPR006179 http://www.ebi.ac.uk/interpro/entry/IPR006179 InterPro IPR006294 http://www.ebi.ac.uk/interpro/entry/IPR006294 InterPro IPR008334 http://www.ebi.ac.uk/interpro/entry/IPR008334 InterPro IPR029052 http://www.ebi.ac.uk/interpro/entry/IPR029052 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4171 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4171 KEGG_Gene eco:b4213 http://www.genome.jp/dbget-bin/www_bget?eco:b4213 KEGG_Orthology KO:K01119 http://www.genome.jp/dbget-bin/www_bget?KO:K01119 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Reaction rn:R03537 http://www.genome.jp/dbget-bin/www_bget?rn:R03537 KEGG_Reaction rn:R03538 http://www.genome.jp/dbget-bin/www_bget?rn:R03538 KEGG_Reaction rn:R03929 http://www.genome.jp/dbget-bin/www_bget?rn:R03929 KEGG_Reaction rn:R05135 http://www.genome.jp/dbget-bin/www_bget?rn:R05135 MINT MINT-1228170 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1228170 OMA MVWDKAN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MVWDKAN PANTHER PTHR11575 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11575 PRINTS PR01607 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01607 PROSITE PS00785 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00785 PROSITE PS00786 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00786 PSORT swissprot:CPDB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CPDB_ECOLI PSORT-B swissprot:CPDB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CPDB_ECOLI PSORT2 swissprot:CPDB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CPDB_ECOLI Pfam PF00149 http://pfam.xfam.org/family/PF00149 Pfam PF02872 http://pfam.xfam.org/family/PF02872 Phobius swissprot:CPDB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CPDB_ECOLI ProteinModelPortal P08331 http://www.proteinmodelportal.org/query/uniprot/P08331 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2172762 http://www.ncbi.nlm.nih.gov/pubmed/2172762 PubMed 3005231 http://www.ncbi.nlm.nih.gov/pubmed/3005231 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_418634 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418634 RefSeq WP_000589431 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000589431 SMR P08331 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P08331 STRING 511145.b4213 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4213&targetmode=cogs STRING COG0737 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0737&targetmode=cogs SUPFAM SSF55816 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55816 SUPFAM SSF56300 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56300 TIGRFAMs TIGR01390 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01390 UniProtKB CPDB_ECOLI http://www.uniprot.org/uniprot/CPDB_ECOLI UniProtKB-AC P08331 http://www.uniprot.org/uniprot/P08331 charge swissprot:CPDB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CPDB_ECOLI eggNOG COG0737 http://eggnogapi.embl.de/nog_data/html/tree/COG0737 eggNOG ENOG4107RNS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107RNS epestfind swissprot:CPDB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CPDB_ECOLI garnier swissprot:CPDB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CPDB_ECOLI helixturnhelix swissprot:CPDB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CPDB_ECOLI hmoment swissprot:CPDB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CPDB_ECOLI iep swissprot:CPDB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CPDB_ECOLI inforesidue swissprot:CPDB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CPDB_ECOLI octanol swissprot:CPDB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CPDB_ECOLI pepcoil swissprot:CPDB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CPDB_ECOLI pepdigest swissprot:CPDB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CPDB_ECOLI pepinfo swissprot:CPDB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CPDB_ECOLI pepnet swissprot:CPDB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CPDB_ECOLI pepstats swissprot:CPDB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CPDB_ECOLI pepwheel swissprot:CPDB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CPDB_ECOLI pepwindow swissprot:CPDB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CPDB_ECOLI sigcleave swissprot:CPDB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CPDB_ECOLI ## Database ID URL or Descriptions # BioGrid 4261222 7 # CDD cd06223 PRTases_typeI # EcoGene EG12934 gntX # FUNCTION GNTX_ECOLI Could be involved in gluconate metabolism. {ECO 0000269|PubMed 9871335}. # GO_process GO:0046121 deoxyribonucleoside catabolic process; IMP:EcoCyc. # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.2020 -; 1. # InterPro IPR000836 PRibTrfase_dom # InterPro IPR005222 Competence_ComF # InterPro IPR029057 PRTase-like # Organism GNTX_ECOLI Escherichia coli (strain K12) # PATRIC 32122264 VBIEscCol129921_3509 # PIR H65136 H65136 # Pfam PF00156 Pribosyltran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GNTX_ECOLI Protein GntX # RefSeq NP_417872 NC_000913.3 # RefSeq WP_001333371 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA58211.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ComF/GntX family. {ECO 0000305}. # SUPFAM SSF53271 SSF53271 # TIGRFAMs TIGR00201 comF # eggNOG COG1040 LUCA # eggNOG ENOG4105MJ2 Bacteria BLAST swissprot:GNTX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GNTX_ECOLI BioCyc ECOL316407:JW5691-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5691-MONOMER BioCyc EcoCyc:G7747-MONOMER http://biocyc.org/getid?id=EcoCyc:G7747-MONOMER DOI 10.1002/(SICI)1521-4028(199811)38:5/6<395::AID-JOBM395>3.3.CO http://dx.doi.org/10.1002/(SICI)1521-4028(199811)38:5/6<395::AID-JOBM395>3.3.CO DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2770 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2770 EcoGene EG12934 http://www.ecogene.org/geneInfo.php?eg_id=EG12934 EnsemblBacteria AAC76438 http://www.ensemblgenomes.org/id/AAC76438 EnsemblBacteria AAC76438 http://www.ensemblgenomes.org/id/AAC76438 EnsemblBacteria BAE77878 http://www.ensemblgenomes.org/id/BAE77878 EnsemblBacteria BAE77878 http://www.ensemblgenomes.org/id/BAE77878 EnsemblBacteria BAE77878 http://www.ensemblgenomes.org/id/BAE77878 EnsemblBacteria b3413 http://www.ensemblgenomes.org/id/b3413 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0046121 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046121 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.2020 http://www.cathdb.info/version/latest/superfamily/3.40.50.2020 GeneID 947915 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947915 HOGENOM HOG000075042 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000075042&db=HOGENOM6 InParanoid P46846 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P46846 InterPro IPR000836 http://www.ebi.ac.uk/interpro/entry/IPR000836 InterPro IPR005222 http://www.ebi.ac.uk/interpro/entry/IPR005222 InterPro IPR029057 http://www.ebi.ac.uk/interpro/entry/IPR029057 KEGG_Gene ecj:JW5691 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5691 KEGG_Gene eco:b3413 http://www.genome.jp/dbget-bin/www_bget?eco:b3413 OMA LARWLGC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LARWLGC PSORT swissprot:GNTX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GNTX_ECOLI PSORT-B swissprot:GNTX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GNTX_ECOLI PSORT2 swissprot:GNTX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GNTX_ECOLI Pfam PF00156 http://pfam.xfam.org/family/PF00156 Phobius swissprot:GNTX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GNTX_ECOLI PhylomeDB P46846 http://phylomedb.org/?seqid=P46846 ProteinModelPortal P46846 http://www.proteinmodelportal.org/query/uniprot/P46846 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9871335 http://www.ncbi.nlm.nih.gov/pubmed/9871335 RefSeq NP_417872 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417872 RefSeq WP_001333371 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001333371 STRING 511145.b3413 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3413&targetmode=cogs SUPFAM SSF53271 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53271 TIGRFAMs TIGR00201 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00201 UniProtKB GNTX_ECOLI http://www.uniprot.org/uniprot/GNTX_ECOLI UniProtKB-AC P46846 http://www.uniprot.org/uniprot/P46846 charge swissprot:GNTX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GNTX_ECOLI eggNOG COG1040 http://eggnogapi.embl.de/nog_data/html/tree/COG1040 eggNOG ENOG4105MJ2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105MJ2 epestfind swissprot:GNTX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GNTX_ECOLI garnier swissprot:GNTX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GNTX_ECOLI helixturnhelix swissprot:GNTX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GNTX_ECOLI hmoment swissprot:GNTX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GNTX_ECOLI iep swissprot:GNTX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GNTX_ECOLI inforesidue swissprot:GNTX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GNTX_ECOLI octanol swissprot:GNTX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GNTX_ECOLI pepcoil swissprot:GNTX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GNTX_ECOLI pepdigest swissprot:GNTX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GNTX_ECOLI pepinfo swissprot:GNTX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GNTX_ECOLI pepnet swissprot:GNTX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GNTX_ECOLI pepstats swissprot:GNTX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GNTX_ECOLI pepwheel swissprot:GNTX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GNTX_ECOLI pepwindow swissprot:GNTX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GNTX_ECOLI sigcleave swissprot:GNTX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GNTX_ECOLI ## Database ID URL or Descriptions # BioGrid 4261660 11 # EcoGene EG14251 ymfM # IntAct P75977 13 # Organism YMFM_ECOLI Escherichia coli (strain K12) # PIR A64860 A64860 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YMFM_ECOLI Uncharacterized protein YmfM # RefSeq NP_415666 NC_000913.3 # RefSeq WP_001350501 NZ_CP010440.1 BLAST swissprot:YMFM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YMFM_ECOLI BioCyc ECOL316407:JW1134-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1134-MONOMER BioCyc EcoCyc:G6592-MONOMER http://biocyc.org/getid?id=EcoCyc:G6592-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3999 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3999 EcoGene EG14251 http://www.ecogene.org/geneInfo.php?eg_id=EG14251 EnsemblBacteria AAC74232 http://www.ensemblgenomes.org/id/AAC74232 EnsemblBacteria AAC74232 http://www.ensemblgenomes.org/id/AAC74232 EnsemblBacteria BAE76380 http://www.ensemblgenomes.org/id/BAE76380 EnsemblBacteria BAE76380 http://www.ensemblgenomes.org/id/BAE76380 EnsemblBacteria BAE76380 http://www.ensemblgenomes.org/id/BAE76380 EnsemblBacteria b1148 http://www.ensemblgenomes.org/id/b1148 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945715 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945715 HOGENOM HOG000123870 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000123870&db=HOGENOM6 IntAct P75977 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75977* KEGG_Gene ecj:JW1134 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1134 KEGG_Gene eco:b1148 http://www.genome.jp/dbget-bin/www_bget?eco:b1148 OMA THRFAEW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=THRFAEW PSORT swissprot:YMFM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YMFM_ECOLI PSORT-B swissprot:YMFM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YMFM_ECOLI PSORT2 swissprot:YMFM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YMFM_ECOLI Phobius swissprot:YMFM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YMFM_ECOLI ProteinModelPortal P75977 http://www.proteinmodelportal.org/query/uniprot/P75977 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415666 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415666 RefSeq WP_001350501 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001350501 SMR P75977 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75977 STRING 511145.b1148 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1148&targetmode=cogs UniProtKB YMFM_ECOLI http://www.uniprot.org/uniprot/YMFM_ECOLI UniProtKB-AC P75977 http://www.uniprot.org/uniprot/P75977 charge swissprot:YMFM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YMFM_ECOLI epestfind swissprot:YMFM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YMFM_ECOLI garnier swissprot:YMFM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YMFM_ECOLI helixturnhelix swissprot:YMFM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YMFM_ECOLI hmoment swissprot:YMFM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YMFM_ECOLI iep swissprot:YMFM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YMFM_ECOLI inforesidue swissprot:YMFM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YMFM_ECOLI octanol swissprot:YMFM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YMFM_ECOLI pepcoil swissprot:YMFM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YMFM_ECOLI pepdigest swissprot:YMFM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YMFM_ECOLI pepinfo swissprot:YMFM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YMFM_ECOLI pepnet swissprot:YMFM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YMFM_ECOLI pepstats swissprot:YMFM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YMFM_ECOLI pepwheel swissprot:YMFM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YMFM_ECOLI pepwindow swissprot:YMFM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YMFM_ECOLI sigcleave swissprot:YMFM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YMFM_ECOLI ## Database ID URL or Descriptions # BioGrid 4260211 201 # CDD cd06261 TM_PBP2 # EcoGene EG13789 ddpB # FUNCTION DDPB_ECOLI Part of the ABC transporter complex DdpABCDF, which is probably involved in D,D-dipeptide transport. Probably responsible for the translocation of the substrate across the membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0022857 transmembrane transporter activity; IBA:GO_Central. # GO_function GO:0042936 dipeptide transporter activity; IBA:GO_Central. # GO_process GO:0015031 protein transport; IEA:UniProtKB-KW. # GO_process GO:0055085 transmembrane transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # Gene3D 1.10.3720.10 -; 2. # INDUCTION Induced by RpoS in stationary phase. {ECO:0000269|PubMed 9751644}. # IntAct P77308 2 # InterPro IPR000515 MetI-like # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00239 Peptides/nickel transport system # KEGG_Brite ko02000 Transporters # Organism DDPB_ECOLI Escherichia coli (strain K12) # PATRIC 32118266 VBIEscCol129921_1553 # PIR A64902 A64902 # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DDPB_ECOLI Probable D,D-dipeptide transport system permease protein DdpB # RefSeq NP_416003 NC_000913.3 # RefSeq WP_000145123 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION DDPB_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT The complex is composed of two ATP-binding proteins (DdpD and DdpF), two transmembrane proteins (DdpB and DdpC) and a solute-binding protein (DdpA). {ECO 0000305}. # SUPFAM SSF161098 SSF161098; 2 # TCDB 3.A.1.5.38 the atp-binding cassette (abc) superfamily # eggNOG COG0601 LUCA # eggNOG ENOG4105CJM Bacteria BLAST swissprot:DDPB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DDPB_ECOLI BioCyc ECOL316407:JW1481-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1481-MONOMER BioCyc EcoCyc:YDDR-MONOMER http://biocyc.org/getid?id=EcoCyc:YDDR-MONOMER COG COG0601 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0601 DIP DIP-11671N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11671N DOI 10.1016/S1074-5521(98)90005-9 http://dx.doi.org/10.1016/S1074-5521(98)90005-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.96.20.11028 http://dx.doi.org/10.1073/pnas.96.20.11028 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3550 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3550 EcoGene EG13789 http://www.ecogene.org/geneInfo.php?eg_id=EG13789 EnsemblBacteria AAC74559 http://www.ensemblgenomes.org/id/AAC74559 EnsemblBacteria AAC74559 http://www.ensemblgenomes.org/id/AAC74559 EnsemblBacteria BAA15141 http://www.ensemblgenomes.org/id/BAA15141 EnsemblBacteria BAA15141 http://www.ensemblgenomes.org/id/BAA15141 EnsemblBacteria BAA15141 http://www.ensemblgenomes.org/id/BAA15141 EnsemblBacteria b1486 http://www.ensemblgenomes.org/id/b1486 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GO_function GO:0042936 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042936 GO_process GO:0015031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 946044 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946044 HOGENOM HOG000170242 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000170242&db=HOGENOM6 InParanoid P77308 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77308 IntAct P77308 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77308* InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1481 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1481 KEGG_Gene eco:b1486 http://www.genome.jp/dbget-bin/www_bget?eco:b1486 KEGG_Orthology KO:K02033 http://www.genome.jp/dbget-bin/www_bget?KO:K02033 OMA AAWKHGT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AAWKHGT PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:DDPB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DDPB_ECOLI PSORT-B swissprot:DDPB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DDPB_ECOLI PSORT2 swissprot:DDPB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DDPB_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Phobius swissprot:DDPB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DDPB_ECOLI PhylomeDB P77308 http://phylomedb.org/?seqid=P77308 ProteinModelPortal P77308 http://www.proteinmodelportal.org/query/uniprot/P77308 PubMed 10500118 http://www.ncbi.nlm.nih.gov/pubmed/10500118 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9751644 http://www.ncbi.nlm.nih.gov/pubmed/9751644 RefSeq NP_416003 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416003 RefSeq WP_000145123 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000145123 STRING 511145.b1486 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1486&targetmode=cogs STRING COG0601 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0601&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.5.38 http://www.tcdb.org/search/result.php?tc=3.A.1.5.38 UniProtKB DDPB_ECOLI http://www.uniprot.org/uniprot/DDPB_ECOLI UniProtKB-AC P77308 http://www.uniprot.org/uniprot/P77308 charge swissprot:DDPB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DDPB_ECOLI eggNOG COG0601 http://eggnogapi.embl.de/nog_data/html/tree/COG0601 eggNOG ENOG4105CJM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CJM epestfind swissprot:DDPB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DDPB_ECOLI garnier swissprot:DDPB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DDPB_ECOLI helixturnhelix swissprot:DDPB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DDPB_ECOLI hmoment swissprot:DDPB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DDPB_ECOLI iep swissprot:DDPB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DDPB_ECOLI inforesidue swissprot:DDPB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DDPB_ECOLI octanol swissprot:DDPB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DDPB_ECOLI pepcoil swissprot:DDPB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DDPB_ECOLI pepdigest swissprot:DDPB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DDPB_ECOLI pepinfo swissprot:DDPB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DDPB_ECOLI pepnet swissprot:DDPB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DDPB_ECOLI pepstats swissprot:DDPB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DDPB_ECOLI pepwheel swissprot:DDPB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DDPB_ECOLI pepwindow swissprot:DDPB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DDPB_ECOLI sigcleave swissprot:DDPB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DDPB_ECOLI ## Database ID URL or Descriptions # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # Organism LPFS_ECOLI Escherichia coli (strain K12) # PIR JU0297 JU0297 # Proteomes UP000000625 Chromosome # RecName LPFS_ECOLI Putative fruR/shl operon leader peptide # RefSeq WP_001303787 NZ_LN832404.1 BLAST swissprot:LPFS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LPFS_ECOLI DOI 10.1007/BF00273623 http://dx.doi.org/10.1007/BF00273623 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL M35034 http://www.ebi.ac.uk/ena/data/view/M35034 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X55034 http://www.ebi.ac.uk/ena/data/view/X55034 EchoBASE EB4307 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4307 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv PSORT swissprot:LPFS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LPFS_ECOLI PSORT-B swissprot:LPFS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LPFS_ECOLI PSORT2 swissprot:LPFS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LPFS_ECOLI Phobius swissprot:LPFS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LPFS_ECOLI PubMed 1851954 http://www.ncbi.nlm.nih.gov/pubmed/1851954 PubMed 2198273 http://www.ncbi.nlm.nih.gov/pubmed/2198273 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001303787 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001303787 UniProtKB LPFS_ECOLI http://www.uniprot.org/uniprot/LPFS_ECOLI UniProtKB-AC P0ADF0 http://www.uniprot.org/uniprot/P0ADF0 charge swissprot:LPFS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LPFS_ECOLI epestfind swissprot:LPFS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LPFS_ECOLI garnier swissprot:LPFS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LPFS_ECOLI helixturnhelix swissprot:LPFS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LPFS_ECOLI hmoment swissprot:LPFS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LPFS_ECOLI iep swissprot:LPFS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LPFS_ECOLI inforesidue swissprot:LPFS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LPFS_ECOLI octanol swissprot:LPFS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LPFS_ECOLI pepcoil swissprot:LPFS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LPFS_ECOLI pepdigest swissprot:LPFS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LPFS_ECOLI pepinfo swissprot:LPFS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LPFS_ECOLI pepnet swissprot:LPFS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LPFS_ECOLI pepstats swissprot:LPFS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LPFS_ECOLI pepwheel swissprot:LPFS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LPFS_ECOLI pepwindow swissprot:LPFS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LPFS_ECOLI sigcleave swissprot:LPFS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LPFS_ECOLI ## Database ID URL or Descriptions # BioGrid 4259995 14 # CDD cd06261 TM_PBP2 # EcoGene EG11631 potH # FUNCTION POTH_ECOLI Required for the activity of the bacterial periplasmic transport system of putrescine. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015594 putrescine-importing ATPase activity; IMP:EcoCyc. # GO_process GO:0015847 putrescine transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # Gene3D 1.10.3720.10 -; 1. # InterPro IPR000515 MetI-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00300 Putrescine transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism POTH_ECOLI Escherichia coli (strain K12) # PATRIC 32116917 VBIEscCol129921_0884 # PIR C45313 C45313 # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName POTH_ECOLI Putrescine transport system permease protein PotH # RefSeq NP_415377 NC_000913.3 # RefSeq WP_000105430 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION POTH_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF161098 SSF161098 # TCDB 3.A.1.11 the atp-binding cassette (abc) superfamily # eggNOG COG1176 LUCA # eggNOG ENOG4105F38 Bacteria BLAST swissprot:POTH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:POTH_ECOLI BioCyc ECOL316407:JW0840-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0840-MONOMER BioCyc EcoCyc:POTH-MONOMER http://biocyc.org/getid?id=EcoCyc:POTH-MONOMER BioCyc MetaCyc:POTH-MONOMER http://biocyc.org/getid?id=MetaCyc:POTH-MONOMER COG COG1176 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1176 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M93239 http://www.ebi.ac.uk/ena/data/view/M93239 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1588 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1588 EcoGene EG11631 http://www.ecogene.org/geneInfo.php?eg_id=EG11631 EnsemblBacteria AAC73943 http://www.ensemblgenomes.org/id/AAC73943 EnsemblBacteria AAC73943 http://www.ensemblgenomes.org/id/AAC73943 EnsemblBacteria BAA35567 http://www.ensemblgenomes.org/id/BAA35567 EnsemblBacteria BAA35567 http://www.ensemblgenomes.org/id/BAA35567 EnsemblBacteria BAA35567 http://www.ensemblgenomes.org/id/BAA35567 EnsemblBacteria b0856 http://www.ensemblgenomes.org/id/b0856 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015594 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015594 GO_process GO:0015847 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015847 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 945475 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945475 HOGENOM HOG000263582 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000263582&db=HOGENOM6 InParanoid P31135 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31135 IntAct P31135 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31135* InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0840 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0840 KEGG_Gene eco:b0856 http://www.genome.jp/dbget-bin/www_bget?eco:b0856 KEGG_Orthology KO:K11075 http://www.genome.jp/dbget-bin/www_bget?KO:K11075 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA LWSEFFS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LWSEFFS PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:POTH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:POTH_ECOLI PSORT-B swissprot:POTH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:POTH_ECOLI PSORT2 swissprot:POTH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:POTH_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Phobius swissprot:POTH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:POTH_ECOLI PhylomeDB P31135 http://phylomedb.org/?seqid=P31135 ProteinModelPortal P31135 http://www.proteinmodelportal.org/query/uniprot/P31135 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8416922 http://www.ncbi.nlm.nih.gov/pubmed/8416922 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415377 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415377 RefSeq WP_000105430 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000105430 STRING 511145.b0856 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0856&targetmode=cogs STRING COG1176 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1176&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.11 http://www.tcdb.org/search/result.php?tc=3.A.1.11 UniProtKB POTH_ECOLI http://www.uniprot.org/uniprot/POTH_ECOLI UniProtKB-AC P31135 http://www.uniprot.org/uniprot/P31135 charge swissprot:POTH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:POTH_ECOLI eggNOG COG1176 http://eggnogapi.embl.de/nog_data/html/tree/COG1176 eggNOG ENOG4105F38 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F38 epestfind swissprot:POTH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:POTH_ECOLI garnier swissprot:POTH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:POTH_ECOLI helixturnhelix swissprot:POTH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:POTH_ECOLI hmoment swissprot:POTH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:POTH_ECOLI iep swissprot:POTH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:POTH_ECOLI inforesidue swissprot:POTH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:POTH_ECOLI octanol swissprot:POTH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:POTH_ECOLI pepcoil swissprot:POTH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:POTH_ECOLI pepdigest swissprot:POTH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:POTH_ECOLI pepinfo swissprot:POTH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:POTH_ECOLI pepnet swissprot:POTH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:POTH_ECOLI pepstats swissprot:POTH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:POTH_ECOLI pepwheel swissprot:POTH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:POTH_ECOLI pepwindow swissprot:POTH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:POTH_ECOLI sigcleave swissprot:POTH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:POTH_ECOLI ## Database ID URL or Descriptions # BioGrid 4262178 4 # EcoGene EG13668 ybhL # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR006214 Bax_inhibitor_1-related # Organism YBHL_ECOLI Escherichia coli (strain K12) # PANTHER PTHR23291 PTHR23291 # PATRIC 32116773 VBIEscCol129921_0812 # PIR B64815 B64815 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBHL_ECOLI Inner membrane protein YbhL # RefSeq NP_415307 NC_000913.3 # RefSeq WP_000373624 NZ_LN832404.1 # SIMILARITY Belongs to the BI1 family. {ECO 0000305}. # SUBCELLULAR LOCATION YBHL_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 1.A.14.2 the testis-enhanced gene transfer (tegt) family # eggNOG COG0670 LUCA # eggNOG ENOG4105HFZ Bacteria BLAST swissprot:YBHL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBHL_ECOLI BioCyc ECOL316407:JW0769-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0769-MONOMER BioCyc EcoCyc:G6403-MONOMER http://biocyc.org/getid?id=EcoCyc:G6403-MONOMER COG COG0670 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0670 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3432 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3432 EcoGene EG13668 http://www.ecogene.org/geneInfo.php?eg_id=EG13668 EnsemblBacteria AAC73873 http://www.ensemblgenomes.org/id/AAC73873 EnsemblBacteria AAC73873 http://www.ensemblgenomes.org/id/AAC73873 EnsemblBacteria BAA35444 http://www.ensemblgenomes.org/id/BAA35444 EnsemblBacteria BAA35444 http://www.ensemblgenomes.org/id/BAA35444 EnsemblBacteria BAA35444 http://www.ensemblgenomes.org/id/BAA35444 EnsemblBacteria b0786 http://www.ensemblgenomes.org/id/b0786 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 945401 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945401 HOGENOM HOG000060392 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000060392&db=HOGENOM6 InParanoid P0AAC4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAC4 InterPro IPR006214 http://www.ebi.ac.uk/interpro/entry/IPR006214 KEGG_Gene ecj:JW0769 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0769 KEGG_Gene eco:b0786 http://www.genome.jp/dbget-bin/www_bget?eco:b0786 KEGG_Orthology KO:K06890 http://www.genome.jp/dbget-bin/www_bget?KO:K06890 OMA ATLVNFW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ATLVNFW PANTHER PTHR23291 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23291 PSORT swissprot:YBHL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBHL_ECOLI PSORT-B swissprot:YBHL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBHL_ECOLI PSORT2 swissprot:YBHL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBHL_ECOLI Phobius swissprot:YBHL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBHL_ECOLI PhylomeDB P0AAC4 http://phylomedb.org/?seqid=P0AAC4 ProteinModelPortal P0AAC4 http://www.proteinmodelportal.org/query/uniprot/P0AAC4 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415307 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415307 RefSeq WP_000373624 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000373624 STRING 511145.b0786 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0786&targetmode=cogs STRING COG0670 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0670&targetmode=cogs TCDB 1.A.14.2 http://www.tcdb.org/search/result.php?tc=1.A.14.2 UniProtKB YBHL_ECOLI http://www.uniprot.org/uniprot/YBHL_ECOLI UniProtKB-AC P0AAC4 http://www.uniprot.org/uniprot/P0AAC4 charge swissprot:YBHL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBHL_ECOLI eggNOG COG0670 http://eggnogapi.embl.de/nog_data/html/tree/COG0670 eggNOG ENOG4105HFZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105HFZ epestfind swissprot:YBHL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBHL_ECOLI garnier swissprot:YBHL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBHL_ECOLI helixturnhelix swissprot:YBHL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBHL_ECOLI hmoment swissprot:YBHL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBHL_ECOLI iep swissprot:YBHL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBHL_ECOLI inforesidue swissprot:YBHL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBHL_ECOLI octanol swissprot:YBHL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBHL_ECOLI pepcoil swissprot:YBHL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBHL_ECOLI pepdigest swissprot:YBHL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBHL_ECOLI pepinfo swissprot:YBHL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBHL_ECOLI pepnet swissprot:YBHL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBHL_ECOLI pepstats swissprot:YBHL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBHL_ECOLI pepwheel swissprot:YBHL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBHL_ECOLI pepwindow swissprot:YBHL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBHL_ECOLI sigcleave swissprot:YBHL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBHL_ECOLI ## Database ID URL or Descriptions # AltName CYSM_ECOLI O-acetylserine (thiol)-lyase B # AltName CYSM_ECOLI O-acetylserine sulfhydrylase B # BRENDA 2.5.1.47 2026 # BioGrid 4259326 6 # CATALYTIC ACTIVITY CYSM_ECOLI O-acetyl-L-serine + hydrogen sulfide = L- cysteine + acetate. # COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI 597326; # EcoGene EG10193 cysM # FUNCTION CYSM_ECOLI Two cysteine synthase enzymes are found. Both catalyze the same reaction. Cysteine synthase B can also use thiosulfate in place of sulfide to give cysteine thiosulfonate as a product. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0004124 cysteine synthase activity; IDA:EcoCyc. # GO_function GO:0016740 transferase activity; IEA:UniProtKB-KW. # GO_function GO:0030170 pyridoxal phosphate binding; IBA:GO_Central. # GO_function GO:0080146 L-cysteine desulfhydrase activity; IMP:EcoCyc. # GO_process GO:0006535 cysteine biosynthetic process from serine; IDA:EcoCyc. # GO_process GO:0008652 cellular amino acid biosynthetic process; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # IntAct P16703 21 # InterPro IPR001216 P-phosphate_BS # InterPro IPR001926 TrpB-like_PLP-dep # InterPro IPR005856 Cys_synth # InterPro IPR005858 CysM # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00270 Cysteine and methionine metabolism # KEGG_Pathway ko00920 Sulfur metabolism # Organism CYSM_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-cysteine biosynthesis; L- cysteine from L-serine step 2/2. # PATRIC 32120227 VBIEscCol129921_2516 # PDB 2BHS X-ray; 2.67 A; A/B/C/D=1-303 # PDB 2BHT X-ray; 2.10 A; A/B/C/D=1-303 # PDB 2V03 X-ray; 1.33 A; A=1-303 # PIR D35402 SYECBC # PROSITE PS00901 CYS_SYNTHASE # Pfam PF00291 PALP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CYSM_ECOLI Cysteine synthase B # RefSeq NP_416916 NC_000913.3 # RefSeq WP_001336044 NZ_LN832404.1 # SIMILARITY Belongs to the cysteine synthase/cystathionine beta- synthase family. {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 15952768}. # SUPFAM SSF53686 SSF53686 # TIGRFAMs TIGR01136 cysKM # TIGRFAMs TIGR01138 cysM # UniPathway UPA00136 UER00200 # eggNOG COG0031 LUCA # eggNOG ENOG4105C6T Bacteria BLAST swissprot:CYSM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CYSM_ECOLI BioCyc ECOL316407:JW2414-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2414-MONOMER BioCyc EcoCyc:ACSERLYB-MONOMER http://biocyc.org/getid?id=EcoCyc:ACSERLYB-MONOMER BioCyc MetaCyc:ACSERLYB-MONOMER http://biocyc.org/getid?id=MetaCyc:ACSERLYB-MONOMER COG COG0031 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0031 DIP DIP-9383N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9383N DOI 10.1021/bi050485+ http://dx.doi.org/10.1021/bi050485+ DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.5.1.47 http://www.genome.jp/dbget-bin/www_bget?EC:2.5.1.47 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M32101 http://www.ebi.ac.uk/ena/data/view/M32101 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.5.1.47 http://enzyme.expasy.org/EC/2.5.1.47 EchoBASE EB0190 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0190 EcoGene EG10193 http://www.ecogene.org/geneInfo.php?eg_id=EG10193 EnsemblBacteria AAC75474 http://www.ensemblgenomes.org/id/AAC75474 EnsemblBacteria AAC75474 http://www.ensemblgenomes.org/id/AAC75474 EnsemblBacteria BAA16295 http://www.ensemblgenomes.org/id/BAA16295 EnsemblBacteria BAA16295 http://www.ensemblgenomes.org/id/BAA16295 EnsemblBacteria BAA16295 http://www.ensemblgenomes.org/id/BAA16295 EnsemblBacteria b2421 http://www.ensemblgenomes.org/id/b2421 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004124 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004124 GO_function GO:0016740 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016740 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_function GO:0080146 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0080146 GO_process GO:0006535 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006535 GO_process GO:0008652 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008652 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 946888 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946888 HOGENOM HOG000217394 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000217394&db=HOGENOM6 InParanoid P16703 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P16703 IntAct P16703 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P16703* IntEnz 2.5.1.47 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.5.1.47 InterPro IPR001216 http://www.ebi.ac.uk/interpro/entry/IPR001216 InterPro IPR001926 http://www.ebi.ac.uk/interpro/entry/IPR001926 InterPro IPR005856 http://www.ebi.ac.uk/interpro/entry/IPR005856 InterPro IPR005858 http://www.ebi.ac.uk/interpro/entry/IPR005858 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2414 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2414 KEGG_Gene eco:b2421 http://www.genome.jp/dbget-bin/www_bget?eco:b2421 KEGG_Orthology KO:K12339 http://www.genome.jp/dbget-bin/www_bget?KO:K12339 KEGG_Pathway ko00270 http://www.genome.jp/kegg-bin/show_pathway?ko00270 KEGG_Pathway ko00920 http://www.genome.jp/kegg-bin/show_pathway?ko00920 KEGG_Reaction rn:R00897 http://www.genome.jp/dbget-bin/www_bget?rn:R00897 KEGG_Reaction rn:R03132 http://www.genome.jp/dbget-bin/www_bget?rn:R03132 KEGG_Reaction rn:R03601 http://www.genome.jp/dbget-bin/www_bget?rn:R03601 KEGG_Reaction rn:R04859 http://www.genome.jp/dbget-bin/www_bget?rn:R04859 MINT MINT-1300981 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1300981 OMA FTTTGPE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FTTTGPE PDB 2BHS http://www.ebi.ac.uk/pdbe-srv/view/entry/2BHS PDB 2BHT http://www.ebi.ac.uk/pdbe-srv/view/entry/2BHT PDB 2V03 http://www.ebi.ac.uk/pdbe-srv/view/entry/2V03 PDBsum 2BHS http://www.ebi.ac.uk/pdbsum/2BHS PDBsum 2BHT http://www.ebi.ac.uk/pdbsum/2BHT PDBsum 2V03 http://www.ebi.ac.uk/pdbsum/2V03 PROSITE PS00901 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00901 PSORT swissprot:CYSM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CYSM_ECOLI PSORT-B swissprot:CYSM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CYSM_ECOLI PSORT2 swissprot:CYSM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CYSM_ECOLI Pfam PF00291 http://pfam.xfam.org/family/PF00291 Phobius swissprot:CYSM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CYSM_ECOLI PhylomeDB P16703 http://phylomedb.org/?seqid=P16703 ProteinModelPortal P16703 http://www.proteinmodelportal.org/query/uniprot/P16703 PubMed 15952768 http://www.ncbi.nlm.nih.gov/pubmed/15952768 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2188958 http://www.ncbi.nlm.nih.gov/pubmed/2188958 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416916 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416916 RefSeq WP_001336044 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001336044 SMR P16703 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P16703 STRING 511145.b2421 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2421&targetmode=cogs STRING COG0031 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0031&targetmode=cogs SUPFAM SSF53686 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53686 SWISS-2DPAGE P16703 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P16703 TIGRFAMs TIGR01136 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01136 TIGRFAMs TIGR01138 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01138 UniProtKB CYSM_ECOLI http://www.uniprot.org/uniprot/CYSM_ECOLI UniProtKB-AC P16703 http://www.uniprot.org/uniprot/P16703 charge swissprot:CYSM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CYSM_ECOLI eggNOG COG0031 http://eggnogapi.embl.de/nog_data/html/tree/COG0031 eggNOG ENOG4105C6T http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C6T epestfind swissprot:CYSM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CYSM_ECOLI garnier swissprot:CYSM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CYSM_ECOLI helixturnhelix swissprot:CYSM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CYSM_ECOLI hmoment swissprot:CYSM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CYSM_ECOLI iep swissprot:CYSM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CYSM_ECOLI inforesidue swissprot:CYSM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CYSM_ECOLI octanol swissprot:CYSM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CYSM_ECOLI pepcoil swissprot:CYSM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CYSM_ECOLI pepdigest swissprot:CYSM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CYSM_ECOLI pepinfo swissprot:CYSM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CYSM_ECOLI pepnet swissprot:CYSM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CYSM_ECOLI pepstats swissprot:CYSM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CYSM_ECOLI pepwheel swissprot:CYSM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CYSM_ECOLI pepwindow swissprot:CYSM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CYSM_ECOLI sigcleave swissprot:CYSM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CYSM_ECOLI ## Database ID URL or Descriptions # BioGrid 4259851 12 # EcoGene EG11099 ybaA # IntAct P0AAQ6 15 # InterPro IPR009874 DUF1428 # InterPro IPR011008 Dimeric_a/b-barrel # Organism YBAA_ECOLI Escherichia coli (strain K12) # PATRIC 32116065 VBIEscCol129921_0474 # PIR S07261 S07261 # PIRSF PIRSF007028 UCP007028 # Pfam PF07237 DUF1428 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBAA_ECOLI Uncharacterized protein YbaA # RefSeq NP_414989 NC_000913.3 # RefSeq WP_000878140 NZ_LN832404.1 # SUPFAM SSF54909 SSF54909 # TCDB 3.A.5.1 the general secretory pathway (sec) family # eggNOG COG5507 LUCA # eggNOG ENOG4105KCV Bacteria BLAST swissprot:YBAA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBAA_ECOLI BioCyc ECOL316407:JW0445-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0445-MONOMER BioCyc EcoCyc:EG11099-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11099-MONOMER DOI 10.1016/0022-2836(84)90236-5 http://dx.doi.org/10.1016/0022-2836(84)90236-5 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL X01074 http://www.ebi.ac.uk/ena/data/view/X01074 EchoBASE EB1091 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1091 EcoGene EG11099 http://www.ecogene.org/geneInfo.php?eg_id=EG11099 EnsemblBacteria AAC73558 http://www.ensemblgenomes.org/id/AAC73558 EnsemblBacteria AAC73558 http://www.ensemblgenomes.org/id/AAC73558 EnsemblBacteria BAE76235 http://www.ensemblgenomes.org/id/BAE76235 EnsemblBacteria BAE76235 http://www.ensemblgenomes.org/id/BAE76235 EnsemblBacteria BAE76235 http://www.ensemblgenomes.org/id/BAE76235 EnsemblBacteria b0456 http://www.ensemblgenomes.org/id/b0456 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 948863 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948863 HOGENOM HOG000117599 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117599&db=HOGENOM6 InParanoid P0AAQ6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAQ6 IntAct P0AAQ6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAQ6* InterPro IPR009874 http://www.ebi.ac.uk/interpro/entry/IPR009874 InterPro IPR011008 http://www.ebi.ac.uk/interpro/entry/IPR011008 KEGG_Gene ecj:JW0445 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0445 KEGG_Gene eco:b0456 http://www.genome.jp/dbget-bin/www_bget?eco:b0456 OMA ECIGDDV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ECIGDDV PSORT swissprot:YBAA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBAA_ECOLI PSORT-B swissprot:YBAA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBAA_ECOLI PSORT2 swissprot:YBAA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBAA_ECOLI Pfam PF07237 http://pfam.xfam.org/family/PF07237 Phobius swissprot:YBAA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBAA_ECOLI PhylomeDB P0AAQ6 http://phylomedb.org/?seqid=P0AAQ6 ProteinModelPortal P0AAQ6 http://www.proteinmodelportal.org/query/uniprot/P0AAQ6 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6208370 http://www.ncbi.nlm.nih.gov/pubmed/6208370 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414989 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414989 RefSeq WP_000878140 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000878140 SMR P0AAQ6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAQ6 STRING 511145.b0456 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0456&targetmode=cogs SUPFAM SSF54909 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54909 TCDB 3.A.5.1 http://www.tcdb.org/search/result.php?tc=3.A.5.1 UniProtKB YBAA_ECOLI http://www.uniprot.org/uniprot/YBAA_ECOLI UniProtKB-AC P0AAQ6 http://www.uniprot.org/uniprot/P0AAQ6 charge swissprot:YBAA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBAA_ECOLI eggNOG COG5507 http://eggnogapi.embl.de/nog_data/html/tree/COG5507 eggNOG ENOG4105KCV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KCV epestfind swissprot:YBAA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBAA_ECOLI garnier swissprot:YBAA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBAA_ECOLI helixturnhelix swissprot:YBAA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBAA_ECOLI hmoment swissprot:YBAA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBAA_ECOLI iep swissprot:YBAA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBAA_ECOLI inforesidue swissprot:YBAA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBAA_ECOLI octanol swissprot:YBAA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBAA_ECOLI pepcoil swissprot:YBAA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBAA_ECOLI pepdigest swissprot:YBAA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBAA_ECOLI pepinfo swissprot:YBAA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBAA_ECOLI pepnet swissprot:YBAA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBAA_ECOLI pepstats swissprot:YBAA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBAA_ECOLI pepwheel swissprot:YBAA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBAA_ECOLI pepwindow swissprot:YBAA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBAA_ECOLI sigcleave swissprot:YBAA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBAA_ECOLI ## Database ID URL or Descriptions # AltName RLMM_ECOLI 23S rRNA (cytidine2498-2'-O)-methyltransferase # AltName RLMM_ECOLI 23S rRNA 2'-O-ribose methyltransferase RlmM # BRENDA 2.1.1.186 2026 # BioGrid 4263537 17 # CATALYTIC ACTIVITY RLMM_ECOLI S-adenosyl-L-methionine + cytidine(2498) in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine(2498) in 23S rRNA. {ECO 0000269|PubMed 19400805, ECO 0000269|PubMed 22923526}. # DOMAIN RLMM_ECOLI Consists of two structural domains an N-terminal THUMP domain followed by a C-terminal catalytic Rossmann-like fold MTase domain in a novel arrangement. The two domains are connected by a long loop. {ECO 0000269|PubMed 22923526}. # EcoGene EG11794 rlmM # FUNCTION RLMM_ECOLI Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA. Modifies C2498 in naked 23S rRNA, but not in assembled 50S subunits or ribosomes. {ECO 0000269|PubMed 19400805, ECO 0000269|PubMed 22923526}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0070677 rRNA (cytosine-2'-O-)-methyltransferase activity; IDA:EcoCyc. # GO_process GO:0000453 enzyme-directed rRNA 2'-O-methylation; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.50.150 -; 1. # HAMAP MF_01551 23SrRNA_methyltr_M # IntAct P0ADR6 14 # InterPro IPR002877 rRNA_MeTrfase_FtsJ_dom # InterPro IPR011224 rRNA_MeTrfase_M # InterPro IPR029063 SAM-dependent_MTases # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # Organism RLMM_ECOLI Escherichia coli (strain K12) # PATRIC 32121028 VBIEscCol129921_2906 # PDB 4ATN X-ray; 1.95 A; A=1-366 # PDB 4AUK X-ray; 1.90 A; A/B=1-366 # PDB 4B17 X-ray; 2.60 A; A=1-366 # PIR I41067 I41067 # PIRSF PIRSF028774 UCP028774 # Pfam PF01728 FtsJ # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RLMM_ECOLI Ribosomal RNA large subunit methyltransferase M # RefSeq NP_417286 NC_000913.3 # RefSeq WP_001045520 NZ_LN832404.1 # SIMILARITY Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION RLMM_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Monomer. {ECO:0000269|PubMed 22923526}. # SUPFAM SSF53335 SSF53335 # eggNOG COG2933 LUCA # eggNOG ENOG4105EZ6 Bacteria BLAST swissprot:RLMM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RLMM_ECOLI BioCyc ECOL316407:JW2777-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2777-MONOMER BioCyc EcoCyc:EG11794-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11794-MONOMER BioCyc MetaCyc:EG11794-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11794-MONOMER COG COG2933 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2933 DOI 10.1016/S0378-1119(02)01097-1 http://dx.doi.org/10.1016/S0378-1119(02)01097-1 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gks727 http://dx.doi.org/10.1093/nar/gks727 DOI 10.1099/13500872-141-2-419 http://dx.doi.org/10.1099/13500872-141-2-419 DOI 10.1111/j.1365-2958.2009.06709.x http://dx.doi.org/10.1111/j.1365-2958.2009.06709.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.1.186 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.186 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 EMBL X73413 http://www.ebi.ac.uk/ena/data/view/X73413 ENZYME 2.1.1.186 http://enzyme.expasy.org/EC/2.1.1.186 EchoBASE EB1742 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1742 EcoGene EG11794 http://www.ecogene.org/geneInfo.php?eg_id=EG11794 EnsemblBacteria AAC75848 http://www.ensemblgenomes.org/id/AAC75848 EnsemblBacteria AAC75848 http://www.ensemblgenomes.org/id/AAC75848 EnsemblBacteria BAE76878 http://www.ensemblgenomes.org/id/BAE76878 EnsemblBacteria BAE76878 http://www.ensemblgenomes.org/id/BAE76878 EnsemblBacteria BAE76878 http://www.ensemblgenomes.org/id/BAE76878 EnsemblBacteria b2806 http://www.ensemblgenomes.org/id/b2806 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0070677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070677 GO_process GO:0000453 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000453 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 GeneID 947283 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947283 HAMAP MF_01551 http://hamap.expasy.org/unirule/MF_01551 HOGENOM HOG000247137 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000247137&db=HOGENOM6 InParanoid P0ADR6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADR6 IntAct P0ADR6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADR6* IntEnz 2.1.1.186 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.186 InterPro IPR002877 http://www.ebi.ac.uk/interpro/entry/IPR002877 InterPro IPR011224 http://www.ebi.ac.uk/interpro/entry/IPR011224 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW2777 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2777 KEGG_Gene eco:b2806 http://www.genome.jp/dbget-bin/www_bget?eco:b2806 KEGG_Orthology KO:K06968 http://www.genome.jp/dbget-bin/www_bget?KO:K06968 OMA VIFECYQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VIFECYQ PDB 4ATN http://www.ebi.ac.uk/pdbe-srv/view/entry/4ATN PDB 4AUK http://www.ebi.ac.uk/pdbe-srv/view/entry/4AUK PDB 4B17 http://www.ebi.ac.uk/pdbe-srv/view/entry/4B17 PDBsum 4ATN http://www.ebi.ac.uk/pdbsum/4ATN PDBsum 4AUK http://www.ebi.ac.uk/pdbsum/4AUK PDBsum 4B17 http://www.ebi.ac.uk/pdbsum/4B17 PSORT swissprot:RLMM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RLMM_ECOLI PSORT-B swissprot:RLMM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RLMM_ECOLI PSORT2 swissprot:RLMM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RLMM_ECOLI Pfam PF01728 http://pfam.xfam.org/family/PF01728 Phobius swissprot:RLMM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RLMM_ECOLI ProteinModelPortal P0ADR6 http://www.proteinmodelportal.org/query/uniprot/P0ADR6 PubMed 11293658 http://www.ncbi.nlm.nih.gov/pubmed/11293658 PubMed 12527203 http://www.ncbi.nlm.nih.gov/pubmed/12527203 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19400805 http://www.ncbi.nlm.nih.gov/pubmed/19400805 PubMed 22923526 http://www.ncbi.nlm.nih.gov/pubmed/22923526 PubMed 7704273 http://www.ncbi.nlm.nih.gov/pubmed/7704273 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417286 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417286 RefSeq WP_001045520 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001045520 SMR P0ADR6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADR6 STRING 511145.b2806 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2806&targetmode=cogs STRING COG2933 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2933&targetmode=cogs SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 UniProtKB RLMM_ECOLI http://www.uniprot.org/uniprot/RLMM_ECOLI UniProtKB-AC P0ADR6 http://www.uniprot.org/uniprot/P0ADR6 charge swissprot:RLMM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RLMM_ECOLI eggNOG COG2933 http://eggnogapi.embl.de/nog_data/html/tree/COG2933 eggNOG ENOG4105EZ6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EZ6 epestfind swissprot:RLMM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RLMM_ECOLI garnier swissprot:RLMM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RLMM_ECOLI helixturnhelix swissprot:RLMM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RLMM_ECOLI hmoment swissprot:RLMM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RLMM_ECOLI iep swissprot:RLMM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RLMM_ECOLI inforesidue swissprot:RLMM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RLMM_ECOLI octanol swissprot:RLMM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RLMM_ECOLI pepcoil swissprot:RLMM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RLMM_ECOLI pepdigest swissprot:RLMM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RLMM_ECOLI pepinfo swissprot:RLMM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RLMM_ECOLI pepnet swissprot:RLMM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RLMM_ECOLI pepstats swissprot:RLMM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RLMM_ECOLI pepwheel swissprot:RLMM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RLMM_ECOLI pepwindow swissprot:RLMM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RLMM_ECOLI sigcleave swissprot:RLMM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RLMM_ECOLI ## Database ID URL or Descriptions # AltName PTA_ECOLI Phosphotransacetylase # BIOPHYSICOCHEMICAL PROPERTIES PTA_ECOLI Kinetic parameters KM=67.2 uM for acetyl-CoA {ECO 0000269|PubMed 20236319}; KM=44.9 uM for acetyl phosphate {ECO 0000269|PubMed 20236319}; Vmax=177.4 uM/h/mg enzyme for acetyl-CoA-forming reaction {ECO 0000269|PubMed 20236319}; Vmax=23.1 uM/h/mg enzyme for acetyl phosphate-forming reaction {ECO 0000269|PubMed 20236319}; # BRENDA 2.3.1 2026 # BioGrid 4261500 344 # CATALYTIC ACTIVITY PTA_ECOLI Acetyl-CoA + phosphate = CoA + acetyl phosphate. # DISRUPTION PHENOTYPE PTA_ECOLI Severe impairment of growth in anaerobic conditions, as well as in growth on minimal medium. Increased sensitivity to environmental changes. Poor starvation survival and slower growth on glucose, fructose, tryptone broth, or pyruvate, but normal growth on glycerol or succinate. {ECO 0000269|PubMed 10542166, ECO 0000269|PubMed 19852855}. # DOMAIN PTA_ECOLI The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site. {ECO 0000269|PubMed 20236319}. # ENZYME REGULATION Inhibited by NADH and ATP. Pyruvate and PEP act as activators of the acetyl phosphate forming reaction while inhibiting the formation of acetyl-CoA. {ECO:0000269|PubMed 20236319}. # EcoGene EG20173 pta # FUNCTION PTA_ECOLI Involved in acetate metabolism. Catalyzes the reversible interconversion of acetyl-CoA and acetyl phosphate. The direction of the overall reaction changes depending on growth conditions. On minimal medium acetyl-CoA is generated. In rich medium acetyl-CoA is converted to acetate and allowing the cell to dump the excess of acetylation potential in exchange for energy in the form of ATP. {ECO 0000269|PubMed 15687190}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IDA:EcoliWiki. # GO_function GO:0008959 phosphate acetyltransferase activity; IDA:EcoCyc. # GO_process GO:0006083 acetate metabolic process; IMP:CACAO. # GO_process GO:0019413 acetate biosynthetic process; IMP:EcoCyc. # GO_process GO:0019427 acetyl-CoA biosynthetic process from acetate; IMP:EcoCyc. # GO_process GO:0045733 acetate catabolic process; IMP:EcoCyc. # GO_process GO:0070689 L-threonine catabolic process to propionate; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.1390.20 -; 1. # Gene3D 3.40.50.300 -; 1. # INTERACTION PTA_ECOLI P0A9I5 napD; NbExp=2; IntAct=EBI-555015, EBI-554985; # IntAct P0A9M8 27 # InterPro IPR002505 PTA_PTB # InterPro IPR004614 P_AcTrfase # InterPro IPR010766 DRTGG # InterPro IPR016475 P-Actrans_bac # InterPro IPR027417 P-loop_NTPase # InterPro IPR028979 Ser_kin/Pase_Hpr_N-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00430 Taurine and hypotaurine metabolism # KEGG_Pathway ko00620 Pyruvate metabolism # KEGG_Pathway ko00640 Propanoate metabolism # KEGG_Pathway ko00680 Methane metabolism # KEGG_Pathway ko00720 Carbon fixation pathways in prokaryotes # Organism PTA_ECOLI Escherichia coli (strain K12) # PATHWAY Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate step 2/2. # PATRIC 32119965 VBIEscCol129921_2392 # PIR G65001 G65001 # PIR JX0357 JX0357 # PIR S50130 S50130 # PIRSF PIRSF006107 PhpActrans_proteobac # Pfam PF01515 PTA_PTB # Pfam PF07085 DRTGG # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PTA_ECOLI Phosphate acetyltransferase # RefSeq NP_416800 NC_000913.3 # RefSeq WP_000086722 NZ_LN832404.1 # SIMILARITY In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family. {ECO 0000305}. # SIMILARITY In the N-terminal section; belongs to the CobB/CobQ family. {ECO 0000305}. # SUBCELLULAR LOCATION PTA_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Homohexamer. {ECO:0000269|PubMed 20236319}. # SUPFAM SSF52540 SSF52540 # SUPFAM SSF75138 SSF75138 # TIGRFAMs TIGR00651 pta # UniPathway UPA00340 UER00459 # eggNOG COG0280 LUCA # eggNOG COG0857 LUCA # eggNOG ENOG4105C6K Bacteria BLAST swissprot:PTA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTA_ECOLI BioCyc ECOL316407:JW2294-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2294-MONOMER BioCyc EcoCyc:PHOSACETYLTRANS-MONOMER http://biocyc.org/getid?id=EcoCyc:PHOSACETYLTRANS-MONOMER BioCyc MetaCyc:PHOSACETYLTRANS-MONOMER http://biocyc.org/getid?id=MetaCyc:PHOSACETYLTRANS-MONOMER COG COG0280 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0280 COG COG0857 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0857 DIP DIP-35815N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35815N DOI 10.1016/0167-4781(94)90089-2 http://dx.doi.org/10.1016/0167-4781(94)90089-2 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1742-4658.2010.07617.x http://dx.doi.org/10.1111/j.1742-4658.2010.07617.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.187.4.1266-1275.2005 http://dx.doi.org/10.1128/JB.187.4.1266-1275.2005 DOI 10.1186/1475-2859-8-54 http://dx.doi.org/10.1186/1475-2859-8-54 EC_number EC:2.3.1.8 http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.8 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D17576 http://www.ebi.ac.uk/ena/data/view/D17576 EMBL D21123 http://www.ebi.ac.uk/ena/data/view/D21123 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.3.1.8 http://enzyme.expasy.org/EC/2.3.1.8 EchoBASE EB4147 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4147 EcoGene EG20173 http://www.ecogene.org/geneInfo.php?eg_id=EG20173 EnsemblBacteria AAC75357 http://www.ensemblgenomes.org/id/AAC75357 EnsemblBacteria AAC75357 http://www.ensemblgenomes.org/id/AAC75357 EnsemblBacteria BAA16136 http://www.ensemblgenomes.org/id/BAA16136 EnsemblBacteria BAA16136 http://www.ensemblgenomes.org/id/BAA16136 EnsemblBacteria BAA16136 http://www.ensemblgenomes.org/id/BAA16136 EnsemblBacteria b2297 http://www.ensemblgenomes.org/id/b2297 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0008959 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008959 GO_process GO:0006083 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006083 GO_process GO:0019413 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019413 GO_process GO:0019427 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019427 GO_process GO:0045733 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045733 GO_process GO:0070689 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070689 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.1390.20 http://www.cathdb.info/version/latest/superfamily/3.40.1390.20 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 946778 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946778 HOGENOM HOG000053797 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000053797&db=HOGENOM6 InParanoid P0A9M8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9M8 IntAct P0A9M8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9M8* IntEnz 2.3.1.8 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.8 InterPro IPR002505 http://www.ebi.ac.uk/interpro/entry/IPR002505 InterPro IPR004614 http://www.ebi.ac.uk/interpro/entry/IPR004614 InterPro IPR010766 http://www.ebi.ac.uk/interpro/entry/IPR010766 InterPro IPR016475 http://www.ebi.ac.uk/interpro/entry/IPR016475 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR028979 http://www.ebi.ac.uk/interpro/entry/IPR028979 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2294 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2294 KEGG_Gene eco:b2297 http://www.genome.jp/dbget-bin/www_bget?eco:b2297 KEGG_Orthology KO:K13788 http://www.genome.jp/dbget-bin/www_bget?KO:K13788 KEGG_Pathway ko00430 http://www.genome.jp/kegg-bin/show_pathway?ko00430 KEGG_Pathway ko00620 http://www.genome.jp/kegg-bin/show_pathway?ko00620 KEGG_Pathway ko00640 http://www.genome.jp/kegg-bin/show_pathway?ko00640 KEGG_Pathway ko00680 http://www.genome.jp/kegg-bin/show_pathway?ko00680 KEGG_Pathway ko00720 http://www.genome.jp/kegg-bin/show_pathway?ko00720 KEGG_Reaction rn:R00230 http://www.genome.jp/dbget-bin/www_bget?rn:R00230 KEGG_Reaction rn:R00921 http://www.genome.jp/dbget-bin/www_bget?rn:R00921 MINT MINT-1263208 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1263208 OMA KPIAQPH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KPIAQPH PSORT swissprot:PTA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTA_ECOLI PSORT-B swissprot:PTA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTA_ECOLI PSORT2 swissprot:PTA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTA_ECOLI Pfam PF01515 http://pfam.xfam.org/family/PF01515 Pfam PF07085 http://pfam.xfam.org/family/PF07085 Phobius swissprot:PTA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTA_ECOLI PhylomeDB P0A9M8 http://phylomedb.org/?seqid=P0A9M8 ProteinModelPortal P0A9M8 http://www.proteinmodelportal.org/query/uniprot/P0A9M8 PubMed 10542166 http://www.ncbi.nlm.nih.gov/pubmed/10542166 PubMed 15687190 http://www.ncbi.nlm.nih.gov/pubmed/15687190 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19852855 http://www.ncbi.nlm.nih.gov/pubmed/19852855 PubMed 20236319 http://www.ncbi.nlm.nih.gov/pubmed/20236319 PubMed 2536666 http://www.ncbi.nlm.nih.gov/pubmed/2536666 PubMed 7883769 http://www.ncbi.nlm.nih.gov/pubmed/7883769 PubMed 7918659 http://www.ncbi.nlm.nih.gov/pubmed/7918659 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416800 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416800 RefSeq WP_000086722 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000086722 SMR P0A9M8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9M8 STRING 511145.b2297 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2297&targetmode=cogs STRING COG0280 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0280&targetmode=cogs STRING COG0857 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0857&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SUPFAM SSF75138 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF75138 SWISS-2DPAGE P0A9M8 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A9M8 TIGRFAMs TIGR00651 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00651 UniProtKB PTA_ECOLI http://www.uniprot.org/uniprot/PTA_ECOLI UniProtKB-AC P0A9M8 http://www.uniprot.org/uniprot/P0A9M8 charge swissprot:PTA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTA_ECOLI eggNOG COG0280 http://eggnogapi.embl.de/nog_data/html/tree/COG0280 eggNOG COG0857 http://eggnogapi.embl.de/nog_data/html/tree/COG0857 eggNOG ENOG4105C6K http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C6K epestfind swissprot:PTA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTA_ECOLI garnier swissprot:PTA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTA_ECOLI helixturnhelix swissprot:PTA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTA_ECOLI hmoment swissprot:PTA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTA_ECOLI iep swissprot:PTA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTA_ECOLI inforesidue swissprot:PTA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTA_ECOLI octanol swissprot:PTA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTA_ECOLI pepcoil swissprot:PTA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTA_ECOLI pepdigest swissprot:PTA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTA_ECOLI pepinfo swissprot:PTA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTA_ECOLI pepnet swissprot:PTA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTA_ECOLI pepstats swissprot:PTA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTA_ECOLI pepwheel swissprot:PTA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTA_ECOLI pepwindow swissprot:PTA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTA_ECOLI sigcleave swissprot:PTA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262678 9 # EcoGene EG11949 nrfF # FUNCTION NRFF_ECOLI Not required for the biosynthesis of any of the c-type cytochromes. Possible subunit of a heme lyase. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0018378 cytochrome c-heme linkage via heme-L-cysteine; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0006464 cellular protein modification process # InterPro IPR005616 CcmH/CycL/Ccl2/NrfF # InterPro IPR017565 For-dep_Cytc_NO2Rdtase_NrfF # Organism NRFF_ECOLI Escherichia coli (strain K12) # PATRIC 32123699 VBIEscCol129921_4198 # PIR F57987 F57987 # Pfam PF03918 CcmH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NRFF_ECOLI Formate-dependent nitrite reductase complex subunit NrfF # RefSeq NP_418499 NC_000913.3 # RefSeq WP_001032531 NZ_LN832404.1 # SIMILARITY Belongs to the CcmH/CycL/Ccl2/NrfF family. {ECO 0000305}. # SUBCELLULAR LOCATION NRFF_ECOLI Periplasm {ECO 0000305}. # TIGRFAMs TIGR03147 cyt_nit_nrfF # eggNOG COG3088 LUCA BLAST swissprot:NRFF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NRFF_ECOLI BioCyc ECOL316407:JW4036-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4036-MONOMER BioCyc EcoCyc:EG11949-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11949-MONOMER COG COG3088 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3088 DOI 10.1007/BF02173779 http://dx.doi.org/10.1007/BF02173779 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1111/j.1365-2958.1994.tb01004.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb01004.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X72298 http://www.ebi.ac.uk/ena/data/view/X72298 EchoBASE EB1892 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1892 EcoGene EG11949 http://www.ecogene.org/geneInfo.php?eg_id=EG11949 EnsemblBacteria AAD13458 http://www.ensemblgenomes.org/id/AAD13458 EnsemblBacteria AAD13458 http://www.ensemblgenomes.org/id/AAD13458 EnsemblBacteria BAE78077 http://www.ensemblgenomes.org/id/BAE78077 EnsemblBacteria BAE78077 http://www.ensemblgenomes.org/id/BAE78077 EnsemblBacteria BAE78077 http://www.ensemblgenomes.org/id/BAE78077 EnsemblBacteria b4075 http://www.ensemblgenomes.org/id/b4075 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0018378 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018378 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GeneID 948578 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948578 HOGENOM HOG000274670 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000274670&db=HOGENOM6 InParanoid P32711 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32711 InterPro IPR005616 http://www.ebi.ac.uk/interpro/entry/IPR005616 InterPro IPR017565 http://www.ebi.ac.uk/interpro/entry/IPR017565 KEGG_Gene ecj:JW4036 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4036 KEGG_Gene eco:b4075 http://www.genome.jp/dbget-bin/www_bget?eco:b4075 KEGG_Orthology KO:K04017 http://www.genome.jp/dbget-bin/www_bget?KO:K04017 OMA LMILILW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LMILILW PSORT swissprot:NRFF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NRFF_ECOLI PSORT-B swissprot:NRFF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NRFF_ECOLI PSORT2 swissprot:NRFF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NRFF_ECOLI Pfam PF03918 http://pfam.xfam.org/family/PF03918 Phobius swissprot:NRFF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NRFF_ECOLI PhylomeDB P32711 http://phylomedb.org/?seqid=P32711 ProteinModelPortal P32711 http://www.proteinmodelportal.org/query/uniprot/P32711 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8057835 http://www.ncbi.nlm.nih.gov/pubmed/8057835 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 8842153 http://www.ncbi.nlm.nih.gov/pubmed/8842153 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418499 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418499 RefSeq WP_001032531 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001032531 SMR P32711 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32711 STRING 511145.b4075 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4075&targetmode=cogs STRING COG3088 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3088&targetmode=cogs TIGRFAMs TIGR03147 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03147 UniProtKB NRFF_ECOLI http://www.uniprot.org/uniprot/NRFF_ECOLI UniProtKB-AC P32711 http://www.uniprot.org/uniprot/P32711 charge swissprot:NRFF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NRFF_ECOLI eggNOG COG3088 http://eggnogapi.embl.de/nog_data/html/tree/COG3088 epestfind swissprot:NRFF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NRFF_ECOLI garnier swissprot:NRFF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NRFF_ECOLI helixturnhelix swissprot:NRFF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NRFF_ECOLI hmoment swissprot:NRFF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NRFF_ECOLI iep swissprot:NRFF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NRFF_ECOLI inforesidue swissprot:NRFF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NRFF_ECOLI octanol swissprot:NRFF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NRFF_ECOLI pepcoil swissprot:NRFF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NRFF_ECOLI pepdigest swissprot:NRFF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NRFF_ECOLI pepinfo swissprot:NRFF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NRFF_ECOLI pepnet swissprot:NRFF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NRFF_ECOLI pepstats swissprot:NRFF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NRFF_ECOLI pepwheel swissprot:NRFF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NRFF_ECOLI pepwindow swissprot:NRFF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NRFF_ECOLI sigcleave swissprot:NRFF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NRFF_ECOLI ## Database ID URL or Descriptions # BioGrid 4261849 319 # DISRUPTION PHENOTYPE Deletion of yehUT has no obvious phenotypic effect under the conditions tested. {ECO:0000269|PubMed 22685278}. # EcoGene EG12006 yehT # FUNCTION YEHT_ECOLI Member of the two-component regulatory system YehU/YehT, which may be involved in the stationary-phase control network. Regulates expression of yjiY by binding to its promoter region. {ECO 0000269|PubMed 15522865, ECO 0000269|PubMed 22685278}. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0000160 phosphorelay signal transduction system; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_component GO:0005622 intracellular # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # INTERACTION YEHT_ECOLI P0A823 sfsA; NbExp=2; IntAct=EBI-556431, EBI-556413; # IntAct P0AFT5 3 # InterPro IPR001789 Sig_transdc_resp-reg_receiver # InterPro IPR007492 LytTR_DNA-bd_dom # InterPro IPR011006 CheY-like_superfamily # KEGG_Brite ko02022 Two-component system # Organism YEHT_ECOLI Escherichia coli (strain K12) # PATRIC 32119587 VBIEscCol129921_2204 # PIR D64980 D64980 # PROSITE PS50110 RESPONSE_REGULATORY # PROSITE PS50930 HTH_LYTTR # PTM YEHT_ECOLI Phosphorylated by YehU. {ECO 0000269|PubMed 15522865}. # Pfam PF00072 Response_reg # Pfam PF04397 LytTR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEHT_ECOLI Transcriptional regulatory protein YehT # RefSeq NP_416629 NC_000913.3 # RefSeq WP_000598641 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA60488.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Contains 1 HTH LytTR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00112}. # SIMILARITY Contains 1 response regulatory domain. {ECO:0000255|PROSITE-ProRule PRU00169}. # SMART SM00448 REC # SMART SM00850 LytTR # SUPFAM SSF52172 SSF52172 # eggNOG COG3279 LUCA # eggNOG ENOG4108NEV Bacteria BLAST swissprot:YEHT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEHT_ECOLI BioCyc ECOL316407:JW5352-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5352-MONOMER BioCyc EcoCyc:EG12006-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12006-MONOMER COG COG3279 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3279 DIP DIP-48085N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48085N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M410104200 http://dx.doi.org/10.1074/jbc.M410104200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00409-12 http://dx.doi.org/10.1128/JB.00409-12 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1944 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1944 EcoGene EG12006 http://www.ecogene.org/geneInfo.php?eg_id=EG12006 EnsemblBacteria AAC75186 http://www.ensemblgenomes.org/id/AAC75186 EnsemblBacteria AAC75186 http://www.ensemblgenomes.org/id/AAC75186 EnsemblBacteria BAE76601 http://www.ensemblgenomes.org/id/BAE76601 EnsemblBacteria BAE76601 http://www.ensemblgenomes.org/id/BAE76601 EnsemblBacteria BAE76601 http://www.ensemblgenomes.org/id/BAE76601 EnsemblBacteria b2125 http://www.ensemblgenomes.org/id/b2125 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 949024 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949024 HOGENOM HOG000242207 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000242207&db=HOGENOM6 InParanoid P0AFT5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFT5 IntAct P0AFT5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFT5* InterPro IPR001789 http://www.ebi.ac.uk/interpro/entry/IPR001789 InterPro IPR007492 http://www.ebi.ac.uk/interpro/entry/IPR007492 InterPro IPR011006 http://www.ebi.ac.uk/interpro/entry/IPR011006 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW5352 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5352 KEGG_Gene eco:b2125 http://www.genome.jp/dbget-bin/www_bget?eco:b2125 KEGG_Orthology KO:K02477 http://www.genome.jp/dbget-bin/www_bget?KO:K02477 MINT MINT-1311507 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1311507 OMA HDAFALR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HDAFALR PROSITE PS50110 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50110 PROSITE PS50930 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50930 PSORT swissprot:YEHT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEHT_ECOLI PSORT-B swissprot:YEHT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEHT_ECOLI PSORT2 swissprot:YEHT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEHT_ECOLI Pfam PF00072 http://pfam.xfam.org/family/PF00072 Pfam PF04397 http://pfam.xfam.org/family/PF04397 Phobius swissprot:YEHT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEHT_ECOLI PhylomeDB P0AFT5 http://phylomedb.org/?seqid=P0AFT5 ProteinModelPortal P0AFT5 http://www.proteinmodelportal.org/query/uniprot/P0AFT5 PubMed 15522865 http://www.ncbi.nlm.nih.gov/pubmed/15522865 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22685278 http://www.ncbi.nlm.nih.gov/pubmed/22685278 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416629 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416629 RefSeq WP_000598641 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000598641 SMART SM00448 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00448 SMART SM00850 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00850 SMR P0AFT5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFT5 STRING 511145.b2125 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2125&targetmode=cogs STRING COG3279 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3279&targetmode=cogs SUPFAM SSF52172 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52172 UniProtKB YEHT_ECOLI http://www.uniprot.org/uniprot/YEHT_ECOLI UniProtKB-AC P0AFT5 http://www.uniprot.org/uniprot/P0AFT5 charge swissprot:YEHT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEHT_ECOLI eggNOG COG3279 http://eggnogapi.embl.de/nog_data/html/tree/COG3279 eggNOG ENOG4108NEV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108NEV epestfind swissprot:YEHT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEHT_ECOLI garnier swissprot:YEHT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEHT_ECOLI helixturnhelix swissprot:YEHT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEHT_ECOLI hmoment swissprot:YEHT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEHT_ECOLI iep swissprot:YEHT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEHT_ECOLI inforesidue swissprot:YEHT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEHT_ECOLI octanol swissprot:YEHT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEHT_ECOLI pepcoil swissprot:YEHT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEHT_ECOLI pepdigest swissprot:YEHT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEHT_ECOLI pepinfo swissprot:YEHT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEHT_ECOLI pepnet swissprot:YEHT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEHT_ECOLI pepstats swissprot:YEHT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEHT_ECOLI pepwheel swissprot:YEHT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEHT_ECOLI pepwindow swissprot:YEHT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEHT_ECOLI sigcleave swissprot:YEHT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEHT_ECOLI ## Database ID URL or Descriptions # EcoGene EG12927 yrfF # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0009276 Gram-negative-bacterium-type cell wall; IEA:InterPro. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005618 cell wall # GOslim_component GO:0005886 plasma membrane # IntAct P45800 2 # InterPro IPR010771 IgaA # Organism IGAA_ECOLI Escherichia coli (strain K12) # PATRIC 32122230 VBIEscCol129921_3492 # PDB 4UZM NMR; -; A=36-154 # PIR A65135 A65135 # Pfam PF07095 IgaA # ProDom PD147088 IgaA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName IGAA_ECOLI Putative membrane protein IgaA homolog # RefSeq NP_417857 NC_000913.3 # RefSeq WP_000104533 NZ_LN832404.1 # SIMILARITY Belongs to the IgaA family. {ECO 0000305}. # SUBCELLULAR LOCATION IGAA_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG ENOG4105DQY Bacteria # eggNOG ENOG410XNRW LUCA BLAST swissprot:IGAA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:IGAA_ECOLI BioCyc ECOL316407:JW3361-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3361-MONOMER BioCyc EcoCyc:G7741-MONOMER http://biocyc.org/getid?id=EcoCyc:G7741-MONOMER DIP DIP-12922N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12922N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2763 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2763 EcoGene EG12927 http://www.ecogene.org/geneInfo.php?eg_id=EG12927 EnsemblBacteria AAC76423 http://www.ensemblgenomes.org/id/AAC76423 EnsemblBacteria AAC76423 http://www.ensemblgenomes.org/id/AAC76423 EnsemblBacteria BAE77893 http://www.ensemblgenomes.org/id/BAE77893 EnsemblBacteria BAE77893 http://www.ensemblgenomes.org/id/BAE77893 EnsemblBacteria BAE77893 http://www.ensemblgenomes.org/id/BAE77893 EnsemblBacteria b3398 http://www.ensemblgenomes.org/id/b3398 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0009276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009276 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005618 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 947905 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947905 HOGENOM HOG000125564 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125564&db=HOGENOM6 IntAct P45800 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45800* InterPro IPR010771 http://www.ebi.ac.uk/interpro/entry/IPR010771 KEGG_Gene ecj:JW3361 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3361 KEGG_Gene eco:b3398 http://www.genome.jp/dbget-bin/www_bget?eco:b3398 OMA DLIYPPH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DLIYPPH PDB 4UZM http://www.ebi.ac.uk/pdbe-srv/view/entry/4UZM PDBsum 4UZM http://www.ebi.ac.uk/pdbsum/4UZM PSORT swissprot:IGAA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:IGAA_ECOLI PSORT-B swissprot:IGAA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:IGAA_ECOLI PSORT2 swissprot:IGAA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:IGAA_ECOLI Pfam PF07095 http://pfam.xfam.org/family/PF07095 Phobius swissprot:IGAA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:IGAA_ECOLI ProteinModelPortal P45800 http://www.proteinmodelportal.org/query/uniprot/P45800 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417857 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417857 RefSeq WP_000104533 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000104533 SMR P45800 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45800 STRING 511145.b3398 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3398&targetmode=cogs UniProtKB IGAA_ECOLI http://www.uniprot.org/uniprot/IGAA_ECOLI UniProtKB-AC P45800 http://www.uniprot.org/uniprot/P45800 charge swissprot:IGAA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:IGAA_ECOLI eggNOG ENOG4105DQY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DQY eggNOG ENOG410XNRW http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNRW epestfind swissprot:IGAA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:IGAA_ECOLI garnier swissprot:IGAA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:IGAA_ECOLI helixturnhelix swissprot:IGAA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:IGAA_ECOLI hmoment swissprot:IGAA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:IGAA_ECOLI iep swissprot:IGAA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:IGAA_ECOLI inforesidue swissprot:IGAA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:IGAA_ECOLI octanol swissprot:IGAA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:IGAA_ECOLI pepcoil swissprot:IGAA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:IGAA_ECOLI pepdigest swissprot:IGAA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:IGAA_ECOLI pepinfo swissprot:IGAA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:IGAA_ECOLI pepnet swissprot:IGAA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:IGAA_ECOLI pepstats swissprot:IGAA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:IGAA_ECOLI pepwheel swissprot:IGAA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:IGAA_ECOLI pepwindow swissprot:IGAA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:IGAA_ECOLI sigcleave swissprot:IGAA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:IGAA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261643 11 # EcoGene EG12597 yjjU # FUNCTION YJJU_ECOLI Probable lipid hydrolase. {ECO 0000250}. # GO_function GO:0016787 hydrolase activity; IBA:GO_Central. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0016042 lipid catabolic process; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009056 catabolic process # IntAct P39407 11 # InterPro IPR002641 Patatin/PLipase_A2-rel # InterPro IPR016035 Acyl_Trfase/lysoPLipase # Organism YJJU_ECOLI Escherichia coli (strain K12) # PATRIC 32124366 VBIEscCol129921_4523 # PIR S56601 S56601 # PROSITE PS51635 PNPLA # Pfam PF01734 Patatin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJJU_ECOLI Uncharacterized protein YjjU # RefSeq NP_418794 NC_000913.3 # RefSeq WP_001299799 NZ_LN832404.1 # SIMILARITY Contains 1 PNPLA (patatin-like phospholipase) domain. {ECO:0000255|PROSITE-ProRule PRU01161}. # SUPFAM SSF52151 SSF52151 # eggNOG COG4667 LUCA # eggNOG ENOG4108NRW Bacteria BLAST swissprot:YJJU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJJU_ECOLI BioCyc ECOL316407:JW4340-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4340-MONOMER BioCyc EcoCyc:G7951-MONOMER http://biocyc.org/getid?id=EcoCyc:G7951-MONOMER DIP DIP-6892N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-6892N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.1.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 3.1.1.- http://enzyme.expasy.org/EC/3.1.1.- EchoBASE EB2482 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2482 EcoGene EG12597 http://www.ecogene.org/geneInfo.php?eg_id=EG12597 EnsemblBacteria AAC77330 http://www.ensemblgenomes.org/id/AAC77330 EnsemblBacteria AAC77330 http://www.ensemblgenomes.org/id/AAC77330 EnsemblBacteria BAE78366 http://www.ensemblgenomes.org/id/BAE78366 EnsemblBacteria BAE78366 http://www.ensemblgenomes.org/id/BAE78366 EnsemblBacteria BAE78366 http://www.ensemblgenomes.org/id/BAE78366 EnsemblBacteria b4377 http://www.ensemblgenomes.org/id/b4377 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016787 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016787 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0016042 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016042 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GeneID 948906 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948906 HOGENOM HOG000279055 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000279055&db=HOGENOM6 InParanoid P39407 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39407 IntAct P39407 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39407* IntEnz 3.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.1 InterPro IPR002641 http://www.ebi.ac.uk/interpro/entry/IPR002641 InterPro IPR016035 http://www.ebi.ac.uk/interpro/entry/IPR016035 KEGG_Gene ecj:JW4340 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4340 KEGG_Gene eco:b4377 http://www.genome.jp/dbget-bin/www_bget?eco:b4377 OMA SAYVCNQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SAYVCNQ PROSITE PS51635 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51635 PSORT swissprot:YJJU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJJU_ECOLI PSORT-B swissprot:YJJU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJJU_ECOLI PSORT2 swissprot:YJJU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJJU_ECOLI Pfam PF01734 http://pfam.xfam.org/family/PF01734 Phobius swissprot:YJJU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJJU_ECOLI PhylomeDB P39407 http://phylomedb.org/?seqid=P39407 ProteinModelPortal P39407 http://www.proteinmodelportal.org/query/uniprot/P39407 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418794 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418794 RefSeq WP_001299799 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001299799 STRING 511145.b4377 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4377&targetmode=cogs SUPFAM SSF52151 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52151 UniProtKB YJJU_ECOLI http://www.uniprot.org/uniprot/YJJU_ECOLI UniProtKB-AC P39407 http://www.uniprot.org/uniprot/P39407 charge swissprot:YJJU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJJU_ECOLI eggNOG COG4667 http://eggnogapi.embl.de/nog_data/html/tree/COG4667 eggNOG ENOG4108NRW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108NRW epestfind swissprot:YJJU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJJU_ECOLI garnier swissprot:YJJU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJJU_ECOLI helixturnhelix swissprot:YJJU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJJU_ECOLI hmoment swissprot:YJJU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJJU_ECOLI iep swissprot:YJJU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJJU_ECOLI inforesidue swissprot:YJJU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJJU_ECOLI octanol swissprot:YJJU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJJU_ECOLI pepcoil swissprot:YJJU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJJU_ECOLI pepdigest swissprot:YJJU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJJU_ECOLI pepinfo swissprot:YJJU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJJU_ECOLI pepnet swissprot:YJJU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJJU_ECOLI pepstats swissprot:YJJU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJJU_ECOLI pepwheel swissprot:YJJU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJJU_ECOLI pepwindow swissprot:YJJU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJJU_ECOLI sigcleave swissprot:YJJU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJJU_ECOLI ## Database ID URL or Descriptions # BioGrid 4262332 122 # EcoGene EG11161 yggC # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0004849 uridine kinase activity; IBA:GO_Central. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0006206 pyrimidine nucleobase metabolic process; IBA:GO_Central. # GO_process GO:0043097 pyrimidine nucleoside salvage; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.300 -; 1. # InterPro IPR027417 P-loop_NTPase # Organism YGGC_ECOLI Escherichia coli (strain K12) # PATRIC 32121270 VBIEscCol129921_3023 # PIR G65077 QQEC3B # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGGC_ECOLI Uncharacterized protein YggC # RefSeq NP_417403 NC_000913.3 # RefSeq WP_000687705 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA32602.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SUPFAM SSF52540 SSF52540 # eggNOG COG1072 LUCA # eggNOG ENOG4107Z1W Bacteria BLAST swissprot:YGGC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGGC_ECOLI BioCyc ECOL316407:JW2895-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2895-MONOMER BioCyc EcoCyc:EG11161-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11161-MONOMER COG COG1072 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1072 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1989.tb00221.x http://dx.doi.org/10.1111/j.1365-2958.1989.tb00221.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EMBL X14436 http://www.ebi.ac.uk/ena/data/view/X14436 EchoBASE EB1150 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1150 EcoGene EG11161 http://www.ecogene.org/geneInfo.php?eg_id=EG11161 EnsemblBacteria AAC75965 http://www.ensemblgenomes.org/id/AAC75965 EnsemblBacteria AAC75965 http://www.ensemblgenomes.org/id/AAC75965 EnsemblBacteria BAE76992 http://www.ensemblgenomes.org/id/BAE76992 EnsemblBacteria BAE76992 http://www.ensemblgenomes.org/id/BAE76992 EnsemblBacteria BAE76992 http://www.ensemblgenomes.org/id/BAE76992 EnsemblBacteria b2928 http://www.ensemblgenomes.org/id/b2928 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004849 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004849 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006206 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006206 GO_process GO:0043097 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043097 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947419 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947419 HOGENOM HOG000251927 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000251927&db=HOGENOM6 InParanoid P11664 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P11664 IntAct P11664 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P11664* InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Gene ecj:JW2895 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2895 KEGG_Gene eco:b2928 http://www.genome.jp/dbget-bin/www_bget?eco:b2928 KEGG_Orthology KO:K02173 http://www.genome.jp/dbget-bin/www_bget?KO:K02173 OMA ATWPQYD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ATWPQYD PSORT swissprot:YGGC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGGC_ECOLI PSORT-B swissprot:YGGC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGGC_ECOLI PSORT2 swissprot:YGGC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGGC_ECOLI Phobius swissprot:YGGC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGGC_ECOLI PhylomeDB P11664 http://phylomedb.org/?seqid=P11664 ProteinModelPortal P11664 http://www.proteinmodelportal.org/query/uniprot/P11664 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2546007 http://www.ncbi.nlm.nih.gov/pubmed/2546007 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417403 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417403 RefSeq WP_000687705 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000687705 SMR P11664 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P11664 STRING 511145.b2928 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2928&targetmode=cogs STRING COG1072 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1072&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB YGGC_ECOLI http://www.uniprot.org/uniprot/YGGC_ECOLI UniProtKB-AC P11664 http://www.uniprot.org/uniprot/P11664 charge swissprot:YGGC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGGC_ECOLI eggNOG COG1072 http://eggnogapi.embl.de/nog_data/html/tree/COG1072 eggNOG ENOG4107Z1W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107Z1W epestfind swissprot:YGGC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGGC_ECOLI garnier swissprot:YGGC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGGC_ECOLI helixturnhelix swissprot:YGGC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGGC_ECOLI hmoment swissprot:YGGC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGGC_ECOLI iep swissprot:YGGC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGGC_ECOLI inforesidue swissprot:YGGC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGGC_ECOLI octanol swissprot:YGGC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGGC_ECOLI pepcoil swissprot:YGGC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGGC_ECOLI pepdigest swissprot:YGGC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGGC_ECOLI pepinfo swissprot:YGGC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGGC_ECOLI pepnet swissprot:YGGC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGGC_ECOLI pepstats swissprot:YGGC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGGC_ECOLI pepwheel swissprot:YGGC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGGC_ECOLI pepwindow swissprot:YGGC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGGC_ECOLI sigcleave swissprot:YGGC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGGC_ECOLI ## Database ID URL or Descriptions # AltName 16S rRNA m2G1516 methyltransferase {ECO:0000255|HAMAP-Rule MF_01523} # AltName rRNA (guanine-N(2)-)-methyltransferase {ECO:0000255|HAMAP-Rule MF_01523} # BioGrid 4259385 5 # CATALYTIC ACTIVITY RSMJ_ECOLI S-adenosyl-L-methionine + guanine(1516) in 16S rRNA = S-adenosyl-L-homocysteine + N(2)-methylguanine(1516) in 16S rRNA. {ECO 0000255|HAMAP-Rule MF_01523, ECO 0000269|PubMed 22079366}. # DISRUPTION PHENOTYPE Mutants exhibit a cold-sensitive phenotype. {ECO:0000269|PubMed 22079366}. # EcoGene EG12233 rsmJ # FUNCTION RSMJ_ECOLI Specifically methylates the guanosine in position 1516 of 16S rRNA. {ECO 0000255|HAMAP-Rule MF_01523, ECO 0000269|PubMed 22079366}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0008990 rRNA (guanine-N2-)-methyltransferase activity; IDA:UniProtKB. # GO_function GO:0036308 16S rRNA (guanine(1516)-N(2))-methyltransferase activity; IDA:EcoCyc. # GO_process GO:0031167 rRNA methylation; IDA:UniProtKB. # GO_process GO:0070475 rRNA base methylation; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.50.150 -; 1. # HAMAP MF_01523 16SrRNA_methyltr_J # IntAct P68567 7 # InterPro IPR007536 16SrRNA_methylTrfase_J # InterPro IPR029063 SAM-dependent_MTases # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # Organism RSMJ_ECOLI Escherichia coli (strain K12) # PATRIC 32122444 VBIEscCol129921_3599 # PIR D65147 D65147 # Pfam PF04445 SAM_MT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Ribosomal RNA small subunit methyltransferase J {ECO:0000255|HAMAP-Rule MF_01523} # RefSeq NP_417954 NC_000913.3 # RefSeq WP_000686620 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18473.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the methyltransferase superfamily. RsmJ family. {ECO:0000255|HAMAP-Rule MF_01523}. # SUBCELLULAR LOCATION RSMJ_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_01523}. # SUPFAM SSF53335 SSF53335 # eggNOG ENOG4105FFN Bacteria # eggNOG ENOG410XPRJ LUCA BLAST swissprot:RSMJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RSMJ_ECOLI BioCyc ECOL316407:JW5672-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5672-MONOMER BioCyc EcoCyc:EG12233-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12233-MONOMER BioCyc MetaCyc:EG12233-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12233-MONOMER COG COG0500 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0500 DOI 10.1016/j.jmb.2011.10.044 http://dx.doi.org/10.1016/j.jmb.2011.10.044 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.1.242 {ECO:0000255|HAMAP-Rule:MF_01523} http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.242 {ECO:0000255|HAMAP-Rule:MF_01523} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.1.1.242 {ECO:0000255|HAMAP-Rule:MF_01523} http://enzyme.expasy.org/EC/2.1.1.242 {ECO:0000255|HAMAP-Rule:MF_01523} EchoBASE EB2145 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2145 EcoGene EG12233 http://www.ecogene.org/geneInfo.php?eg_id=EG12233 EnsemblBacteria AAC76522 http://www.ensemblgenomes.org/id/AAC76522 EnsemblBacteria AAC76522 http://www.ensemblgenomes.org/id/AAC76522 EnsemblBacteria BAE77797 http://www.ensemblgenomes.org/id/BAE77797 EnsemblBacteria BAE77797 http://www.ensemblgenomes.org/id/BAE77797 EnsemblBacteria BAE77797 http://www.ensemblgenomes.org/id/BAE77797 EnsemblBacteria b3497 http://www.ensemblgenomes.org/id/b3497 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0008990 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008990 GO_function GO:0036308 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036308 GO_process GO:0031167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031167 GO_process GO:0070475 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070475 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 GeneID 948005 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948005 HAMAP MF_01523 http://hamap.expasy.org/unirule/MF_01523 HOGENOM HOG000218236 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218236&db=HOGENOM6 InParanoid P68567 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P68567 IntAct P68567 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P68567* IntEnz 2.1.1.242 {ECO:0000255|HAMAP-Rule:MF_01523} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.242 {ECO:0000255|HAMAP-Rule:MF_01523} InterPro IPR007536 http://www.ebi.ac.uk/interpro/entry/IPR007536 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW5672 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5672 KEGG_Gene eco:b3497 http://www.genome.jp/dbget-bin/www_bget?eco:b3497 KEGG_Orthology KO:K15984 http://www.genome.jp/dbget-bin/www_bget?KO:K15984 OMA SSRYDIY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SSRYDIY PSORT swissprot:RSMJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RSMJ_ECOLI PSORT-B swissprot:RSMJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RSMJ_ECOLI PSORT2 swissprot:RSMJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RSMJ_ECOLI Pfam PF04445 http://pfam.xfam.org/family/PF04445 Phobius swissprot:RSMJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RSMJ_ECOLI PhylomeDB P68567 http://phylomedb.org/?seqid=P68567 ProteinModelPortal P68567 http://www.proteinmodelportal.org/query/uniprot/P68567 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22079366 http://www.ncbi.nlm.nih.gov/pubmed/22079366 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417954 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417954 RefSeq WP_000686620 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000686620 SMR P68567 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P68567 STRING 511145.b3497 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3497&targetmode=cogs STRING COG0500 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0500&targetmode=cogs SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 UniProtKB RSMJ_ECOLI http://www.uniprot.org/uniprot/RSMJ_ECOLI UniProtKB-AC P68567 http://www.uniprot.org/uniprot/P68567 charge swissprot:RSMJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RSMJ_ECOLI eggNOG ENOG4105FFN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FFN eggNOG ENOG410XPRJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPRJ epestfind swissprot:RSMJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RSMJ_ECOLI garnier swissprot:RSMJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RSMJ_ECOLI helixturnhelix swissprot:RSMJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RSMJ_ECOLI hmoment swissprot:RSMJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RSMJ_ECOLI iep swissprot:RSMJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RSMJ_ECOLI inforesidue swissprot:RSMJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RSMJ_ECOLI octanol swissprot:RSMJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RSMJ_ECOLI pepcoil swissprot:RSMJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RSMJ_ECOLI pepdigest swissprot:RSMJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RSMJ_ECOLI pepinfo swissprot:RSMJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RSMJ_ECOLI pepnet swissprot:RSMJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RSMJ_ECOLI pepstats swissprot:RSMJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RSMJ_ECOLI pepwheel swissprot:RSMJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RSMJ_ECOLI pepwindow swissprot:RSMJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RSMJ_ECOLI sigcleave swissprot:RSMJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RSMJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4259669 17 # EcoGene EG13959 ydhY # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0016491 oxidoreductase activity; IBA:GO_Central. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # INDUCTION Up-regulated by the oxygen-responsive transcription factor FNR under anaerobic conditions. Repressed in the presence of nitrate or nitrite via the two-component systems NarXL and NarPQ, respectively. {ECO:0000269|PubMed 18227264}. # IntAct P0AAL6 5 # InterPro IPR017896 4Fe4S_Fe-S-bd # InterPro IPR017900 4Fe4S_Fe_S_CS # Organism YDHY_ECOLI Escherichia coli (strain K12) # PATRIC 32118654 VBIEscCol129921_1745 # PIR B64925 B64925 # PROSITE PS00198 4FE4S_FER_1; 2 # PROSITE PS51379 4FE4S_FER_2; 4 # Pfam PF12800 Fer4_4 # Pfam PF13247 Fer4_11 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDHY_ECOLI Uncharacterized ferredoxin-like protein YdhY # RefSeq NP_416189 NC_000913.3 # RefSeq WP_001070230 NZ_LN832404.1 # SIMILARITY Contains 4 4Fe-4S ferredoxin-type domains. {ECO:0000255|PROSITE-ProRule PRU00711}. # eggNOG COG0437 LUCA # eggNOG ENOG4108PU5 Bacteria BLAST swissprot:YDHY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDHY_ECOLI BioCyc ECOL316407:JW1664-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1664-MONOMER BioCyc EcoCyc:G6902-MONOMER http://biocyc.org/getid?id=EcoCyc:G6902-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1099/mic.0.2007/012146-0 http://dx.doi.org/10.1099/mic.0.2007/012146-0 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U68703 http://www.ebi.ac.uk/ena/data/view/U68703 EchoBASE EB3717 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3717 EcoGene EG13959 http://www.ecogene.org/geneInfo.php?eg_id=EG13959 EnsemblBacteria AAC74744 http://www.ensemblgenomes.org/id/AAC74744 EnsemblBacteria AAC74744 http://www.ensemblgenomes.org/id/AAC74744 EnsemblBacteria BAA15444 http://www.ensemblgenomes.org/id/BAA15444 EnsemblBacteria BAA15444 http://www.ensemblgenomes.org/id/BAA15444 EnsemblBacteria BAA15444 http://www.ensemblgenomes.org/id/BAA15444 EnsemblBacteria b1674 http://www.ensemblgenomes.org/id/b1674 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GeneID 948749 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948749 HOGENOM HOG000012365 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000012365&db=HOGENOM6 InParanoid P0AAL6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAL6 IntAct P0AAL6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAL6* InterPro IPR017896 http://www.ebi.ac.uk/interpro/entry/IPR017896 InterPro IPR017900 http://www.ebi.ac.uk/interpro/entry/IPR017900 KEGG_Gene ecj:JW1664 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1664 KEGG_Gene eco:b1674 http://www.genome.jp/dbget-bin/www_bget?eco:b1674 OMA NQVERPI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NQVERPI PROSITE PS00198 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00198 PROSITE PS51379 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51379 PSORT swissprot:YDHY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDHY_ECOLI PSORT-B swissprot:YDHY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDHY_ECOLI PSORT2 swissprot:YDHY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDHY_ECOLI Pfam PF12800 http://pfam.xfam.org/family/PF12800 Pfam PF13247 http://pfam.xfam.org/family/PF13247 Phobius swissprot:YDHY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDHY_ECOLI PhylomeDB P0AAL6 http://phylomedb.org/?seqid=P0AAL6 ProteinModelPortal P0AAL6 http://www.proteinmodelportal.org/query/uniprot/P0AAL6 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18227264 http://www.ncbi.nlm.nih.gov/pubmed/18227264 PubMed 9023191 http://www.ncbi.nlm.nih.gov/pubmed/9023191 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416189 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416189 RefSeq WP_001070230 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001070230 SMR P0AAL6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAL6 STRING 511145.b1674 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1674&targetmode=cogs UniProtKB YDHY_ECOLI http://www.uniprot.org/uniprot/YDHY_ECOLI UniProtKB-AC P0AAL6 http://www.uniprot.org/uniprot/P0AAL6 charge swissprot:YDHY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDHY_ECOLI eggNOG COG0437 http://eggnogapi.embl.de/nog_data/html/tree/COG0437 eggNOG ENOG4108PU5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108PU5 epestfind swissprot:YDHY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDHY_ECOLI garnier swissprot:YDHY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDHY_ECOLI helixturnhelix swissprot:YDHY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDHY_ECOLI hmoment swissprot:YDHY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDHY_ECOLI iep swissprot:YDHY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDHY_ECOLI inforesidue swissprot:YDHY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDHY_ECOLI octanol swissprot:YDHY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDHY_ECOLI pepcoil swissprot:YDHY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDHY_ECOLI pepdigest swissprot:YDHY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDHY_ECOLI pepinfo swissprot:YDHY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDHY_ECOLI pepnet swissprot:YDHY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDHY_ECOLI pepstats swissprot:YDHY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDHY_ECOLI pepwheel swissprot:YDHY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDHY_ECOLI pepwindow swissprot:YDHY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDHY_ECOLI sigcleave swissprot:YDHY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDHY_ECOLI ## Database ID URL or Descriptions # AltName POXB_ECOLI Pyruvate oxidase # BRENDA 1.2.5 2026 # BioGrid 4262101 12 # CATALYTIC ACTIVITY Pyruvate + ubiquinone + H(2)O = acetate + CO(2) + ubiquinol. {ECO:0000269|PubMed 6752142}. # COFACTOR POXB_ECOLI Name=FAD; Xref=ChEBI CHEBI 57692; Evidence={ECO 0000269|PubMed 6752142}; Note=Binds 1 FAD per subunit. {ECO 0000269|PubMed 6752142}; # COFACTOR POXB_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 6752142}; Note=Binds 1 Mg(2+) ion per subunit. {ECO 0000269|PubMed 6752142}; # COFACTOR POXB_ECOLI Name=thiamine diphosphate; Xref=ChEBI CHEBI 58937; Evidence={ECO 0000269|PubMed 6752142}; Note=Binds 1 thiamine pyrophosphate per subunit. {ECO 0000269|PubMed 6752142}; # DrugBank DB00336 Nitrofural # EcoGene EG10754 poxB # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0008289 lipid binding; IDA:EcoCyc. # GO_function GO:0030976 thiamine pyrophosphate binding; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0050660 flavin adenine dinucleotide binding; IDA:EcoCyc. # GO_function GO:0052737 pyruvate dehydrogenase (quinone) activity; IDA:EcoCyc. # GO_process GO:0006090 pyruvate metabolic process; IMP:EcoCyc. # GO_process GO:0042867 pyruvate catabolic process; IMP:EcoCyc. # GO_process GO:0051289 protein homotetramerization; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008289 lipid binding # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.1220 -; 1. # Gene3D 3.40.50.970 -; 2. # IntAct P07003 4 # InterPro IPR000399 TPP-bd_CS # InterPro IPR011766 TPP_enzyme-bd_C # InterPro IPR012000 Thiamin_PyroP_enz_cen_dom # InterPro IPR012001 Thiamin_PyroP_enz_TPP-bd_dom # InterPro IPR029035 DHS-like_NAD/FAD-binding_dom # InterPro IPR029061 THDP-binding # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00620 Pyruvate metabolism # Organism POXB_ECOLI Escherichia coli (strain K12) # PATRIC 32116949 VBIEscCol129921_0900 # PDB 3EY9 X-ray; 2.90 A; A/B=1-572 # PDB 3EYA X-ray; 2.50 A; A/B/C/D/E/F/G/H/I/J/K/L=1-549 # PIR A23648 DEECPC # PROSITE PS00187 TPP_ENZYMES # PTM POXB_ECOLI Activated by limited proteolytic digestion. This cleavage produces a peptide (alpha-peptide) and mimics the activation of enzyme by phospholipids. The proteolytic cleavage also results in the loss of the high affinity lipid-binding site of the enzyme. # Pfam PF00205 TPP_enzyme_M # Pfam PF02775 TPP_enzyme_C # Pfam PF02776 TPP_enzyme_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName POXB_ECOLI Alpha-peptide # RecName POXB_ECOLI Pyruvate dehydrogenase [ubiquinone] # RefSeq NP_415392 NC_000913.3 # RefSeq WP_000815337 NZ_LN832404.1 # SIMILARITY Belongs to the TPP enzyme family. {ECO 0000305}. # SUBCELLULAR LOCATION POXB_ECOLI Cell membrane; Peripheral membrane protein. # SUBUNIT Homotetramer. {ECO:0000269|PubMed 6752142}. # SUPFAM SSF52467 SSF52467 # SUPFAM SSF52518 SSF52518; 2 # eggNOG COG0028 LUCA # eggNOG ENOG4105C7K Bacteria BLAST swissprot:POXB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:POXB_ECOLI BioCyc ECOL316407:JW0855-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0855-MONOMER BioCyc EcoCyc:PYRUVOXID-MONOMER http://biocyc.org/getid?id=EcoCyc:PYRUVOXID-MONOMER BioCyc MetaCyc:PYRUVOXID-MONOMER http://biocyc.org/getid?id=MetaCyc:PYRUVOXID-MONOMER COG COG0028 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0028 DIP DIP-36216N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36216N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/14.13.5449 http://dx.doi.org/10.1093/nar/14.13.5449 DOI 10.1111/j.1365-2958.1994.tb00380.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb00380.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB00336 http://www.drugbank.ca/drugs/DB00336 EC_number EC:1.2.5.1 http://www.genome.jp/dbget-bin/www_bget?EC:1.2.5.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L47688 http://www.ebi.ac.uk/ena/data/view/L47688 EMBL L47689 http://www.ebi.ac.uk/ena/data/view/L47689 EMBL L47690 http://www.ebi.ac.uk/ena/data/view/L47690 EMBL L47691 http://www.ebi.ac.uk/ena/data/view/L47691 EMBL L47692 http://www.ebi.ac.uk/ena/data/view/L47692 EMBL L47693 http://www.ebi.ac.uk/ena/data/view/L47693 EMBL L47694 http://www.ebi.ac.uk/ena/data/view/L47694 EMBL L47695 http://www.ebi.ac.uk/ena/data/view/L47695 EMBL M28208 http://www.ebi.ac.uk/ena/data/view/M28208 EMBL S73268 http://www.ebi.ac.uk/ena/data/view/S73268 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X04105 http://www.ebi.ac.uk/ena/data/view/X04105 ENZYME 1.2.5.1 http://enzyme.expasy.org/EC/1.2.5.1 EchoBASE EB0747 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0747 EcoGene EG10754 http://www.ecogene.org/geneInfo.php?eg_id=EG10754 EnsemblBacteria AAC73958 http://www.ensemblgenomes.org/id/AAC73958 EnsemblBacteria AAC73958 http://www.ensemblgenomes.org/id/AAC73958 EnsemblBacteria BAA35585 http://www.ensemblgenomes.org/id/BAA35585 EnsemblBacteria BAA35585 http://www.ensemblgenomes.org/id/BAA35585 EnsemblBacteria BAA35585 http://www.ensemblgenomes.org/id/BAA35585 EnsemblBacteria b0871 http://www.ensemblgenomes.org/id/b0871 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0008289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289 GO_function GO:0030976 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030976 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_function GO:0052737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052737 GO_process GO:0006090 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006090 GO_process GO:0042867 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042867 GO_process GO:0051289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051289 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.1220 http://www.cathdb.info/version/latest/superfamily/3.40.50.1220 Gene3D 3.40.50.970 http://www.cathdb.info/version/latest/superfamily/3.40.50.970 GeneID 946132 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946132 InParanoid P07003 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P07003 IntAct P07003 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P07003* IntEnz 1.2.5.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.2.5.1 InterPro IPR000399 http://www.ebi.ac.uk/interpro/entry/IPR000399 InterPro IPR011766 http://www.ebi.ac.uk/interpro/entry/IPR011766 InterPro IPR012000 http://www.ebi.ac.uk/interpro/entry/IPR012000 InterPro IPR012001 http://www.ebi.ac.uk/interpro/entry/IPR012001 InterPro IPR029035 http://www.ebi.ac.uk/interpro/entry/IPR029035 InterPro IPR029061 http://www.ebi.ac.uk/interpro/entry/IPR029061 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0855 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0855 KEGG_Gene eco:b0871 http://www.genome.jp/dbget-bin/www_bget?eco:b0871 KEGG_Orthology KO:K00156 http://www.genome.jp/dbget-bin/www_bget?KO:K00156 KEGG_Pathway ko00620 http://www.genome.jp/kegg-bin/show_pathway?ko00620 KEGG_Reaction rn:R03145 http://www.genome.jp/dbget-bin/www_bget?rn:R03145 OMA RGKEWIQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RGKEWIQ PDB 3EY9 http://www.ebi.ac.uk/pdbe-srv/view/entry/3EY9 PDB 3EYA http://www.ebi.ac.uk/pdbe-srv/view/entry/3EYA PDBsum 3EY9 http://www.ebi.ac.uk/pdbsum/3EY9 PDBsum 3EYA http://www.ebi.ac.uk/pdbsum/3EYA PROSITE PS00187 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00187 PSORT swissprot:POXB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:POXB_ECOLI PSORT-B swissprot:POXB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:POXB_ECOLI PSORT2 swissprot:POXB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:POXB_ECOLI Pfam PF00205 http://pfam.xfam.org/family/PF00205 Pfam PF02775 http://pfam.xfam.org/family/PF02775 Pfam PF02776 http://pfam.xfam.org/family/PF02776 Phobius swissprot:POXB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:POXB_ECOLI PhylomeDB P07003 http://phylomedb.org/?seqid=P07003 ProteinModelPortal P07003 http://www.proteinmodelportal.org/query/uniprot/P07003 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2663858 http://www.ncbi.nlm.nih.gov/pubmed/2663858 PubMed 3016647 http://www.ncbi.nlm.nih.gov/pubmed/3016647 PubMed 3902830 http://www.ncbi.nlm.nih.gov/pubmed/3902830 PubMed 6286628 http://www.ncbi.nlm.nih.gov/pubmed/6286628 PubMed 6752142 http://www.ncbi.nlm.nih.gov/pubmed/6752142 PubMed 8022274 http://www.ncbi.nlm.nih.gov/pubmed/8022274 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_415392 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415392 RefSeq WP_000815337 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000815337 SMR P07003 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P07003 STRING 511145.b0871 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0871&targetmode=cogs STRING COG0028 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0028&targetmode=cogs SUPFAM SSF52467 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52467 SUPFAM SSF52518 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52518 SWISS-2DPAGE P07003 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P07003 UniProtKB POXB_ECOLI http://www.uniprot.org/uniprot/POXB_ECOLI UniProtKB-AC P07003 http://www.uniprot.org/uniprot/P07003 charge swissprot:POXB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:POXB_ECOLI eggNOG COG0028 http://eggnogapi.embl.de/nog_data/html/tree/COG0028 eggNOG ENOG4105C7K http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C7K epestfind swissprot:POXB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:POXB_ECOLI garnier swissprot:POXB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:POXB_ECOLI helixturnhelix swissprot:POXB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:POXB_ECOLI hmoment swissprot:POXB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:POXB_ECOLI iep swissprot:POXB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:POXB_ECOLI inforesidue swissprot:POXB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:POXB_ECOLI octanol swissprot:POXB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:POXB_ECOLI pepcoil swissprot:POXB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:POXB_ECOLI pepdigest swissprot:POXB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:POXB_ECOLI pepinfo swissprot:POXB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:POXB_ECOLI pepnet swissprot:POXB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:POXB_ECOLI pepstats swissprot:POXB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:POXB_ECOLI pepwheel swissprot:POXB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:POXB_ECOLI pepwindow swissprot:POXB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:POXB_ECOLI sigcleave swissprot:POXB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:POXB_ECOLI ## Database ID URL or Descriptions # BioGrid 4262488 12 # EcoGene EG12944 yhhX # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0016491 oxidoreductase activity; IBA:GO_Central. # GO_process GO:0055114 oxidation-reduction process; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.720 -; 1. # IntAct P46853 3 # InterPro IPR000683 Oxidoreductase_N # InterPro IPR004104 OxRdtase_C # InterPro IPR016040 NAD(P)-bd_dom # Organism YHHX_ECOLI Escherichia coli (strain K12) # PATRIC 32122320 VBIEscCol129921_3537 # PDB 3F4L X-ray; 2.00 A; A/B/C/D/E/F=1-345 # PIR C65140 C65140 # Pfam PF01408 GFO_IDH_MocA # Pfam PF02894 GFO_IDH_MocA_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHHX_ECOLI Uncharacterized oxidoreductase YhhX # RefSeq NP_417897 NC_000913.3 # RefSeq WP_000236293 NZ_LN832404.1 # SIMILARITY Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily. {ECO 0000305}. # SUPFAM SSF51735 SSF51735 # eggNOG COG0673 LUCA # eggNOG ENOG4105D9R Bacteria BLAST swissprot:YHHX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHHX_ECOLI BioCyc ECOL316407:JW3403-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3403-MONOMER BioCyc EcoCyc:G7757-MONOMER http://biocyc.org/getid?id=EcoCyc:G7757-MONOMER DIP DIP-12357N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12357N DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- EchoBASE EB2778 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2778 EcoGene EG12944 http://www.ecogene.org/geneInfo.php?eg_id=EG12944 EnsemblBacteria AAC76465 http://www.ensemblgenomes.org/id/AAC76465 EnsemblBacteria AAC76465 http://www.ensemblgenomes.org/id/AAC76465 EnsemblBacteria BAE77853 http://www.ensemblgenomes.org/id/BAE77853 EnsemblBacteria BAE77853 http://www.ensemblgenomes.org/id/BAE77853 EnsemblBacteria BAE77853 http://www.ensemblgenomes.org/id/BAE77853 EnsemblBacteria b3440 http://www.ensemblgenomes.org/id/b3440 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_process GO:0055114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 947944 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947944 HOGENOM HOG000227438 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000227438&db=HOGENOM6 InParanoid P46853 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P46853 IntAct P46853 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P46853* IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR000683 http://www.ebi.ac.uk/interpro/entry/IPR000683 InterPro IPR004104 http://www.ebi.ac.uk/interpro/entry/IPR004104 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 KEGG_Gene ecj:JW3403 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3403 KEGG_Gene eco:b3440 http://www.genome.jp/dbget-bin/www_bget?eco:b3440 OMA YRRSAKP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YRRSAKP PDB 3F4L http://www.ebi.ac.uk/pdbe-srv/view/entry/3F4L PDBsum 3F4L http://www.ebi.ac.uk/pdbsum/3F4L PSORT swissprot:YHHX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHHX_ECOLI PSORT-B swissprot:YHHX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHHX_ECOLI PSORT2 swissprot:YHHX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHHX_ECOLI Pfam PF01408 http://pfam.xfam.org/family/PF01408 Pfam PF02894 http://pfam.xfam.org/family/PF02894 Phobius swissprot:YHHX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHHX_ECOLI PhylomeDB P46853 http://phylomedb.org/?seqid=P46853 ProteinModelPortal P46853 http://www.proteinmodelportal.org/query/uniprot/P46853 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417897 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417897 RefSeq WP_000236293 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000236293 SMR P46853 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P46853 STRING 511145.b3440 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3440&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB YHHX_ECOLI http://www.uniprot.org/uniprot/YHHX_ECOLI UniProtKB-AC P46853 http://www.uniprot.org/uniprot/P46853 charge swissprot:YHHX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHHX_ECOLI eggNOG COG0673 http://eggnogapi.embl.de/nog_data/html/tree/COG0673 eggNOG ENOG4105D9R http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D9R epestfind swissprot:YHHX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHHX_ECOLI garnier swissprot:YHHX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHHX_ECOLI helixturnhelix swissprot:YHHX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHHX_ECOLI hmoment swissprot:YHHX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHHX_ECOLI iep swissprot:YHHX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHHX_ECOLI inforesidue swissprot:YHHX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHHX_ECOLI octanol swissprot:YHHX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHHX_ECOLI pepcoil swissprot:YHHX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHHX_ECOLI pepdigest swissprot:YHHX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHHX_ECOLI pepinfo swissprot:YHHX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHHX_ECOLI pepnet swissprot:YHHX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHHX_ECOLI pepstats swissprot:YHHX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHHX_ECOLI pepwheel swissprot:YHHX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHHX_ECOLI pepwindow swissprot:YHHX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHHX_ECOLI sigcleave swissprot:YHHX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHHX_ECOLI ## Database ID URL or Descriptions # BioGrid 4262534 244 # EcoGene EG12627 dppD # FUNCTION DPPD_ECOLI Part of the binding-protein-dependent transport system for dipeptides. Probably responsible for energy coupling to the transport system. # GO_component GO:0005737 cytoplasm; ISS:EcoCyc. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; ISS:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0015232 heme transporter activity; IMP:EcoliWiki. # GO_function GO:0016887 ATPase activity; IEA:InterPro. # GO_process GO:0015031 protein transport; IEA:UniProtKB-KW. # GO_process GO:0015833 peptide transport; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # Gene3D 3.40.50.300 -; 1. # IntAct P0AAG0 2 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR013563 Oligopep_ABC_C # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00324 Dipeptide transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism DPPD_ECOLI Escherichia coli (strain K12) # PATRIC 32122550 VBIEscCol129921_3653 # PIR S61404 S61404 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # Pfam PF00005 ABC_tran # Pfam PF08352 oligo_HPY # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DPPD_ECOLI Dipeptide transport ATP-binding protein DppD # RefSeq NP_417998 NC_000913.3 # RefSeq WP_001196486 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA # SUBCELLULAR LOCATION DPPD_ECOLI Cell inner membrane {ECO 0000305}; Peripheral membrane protein {ECO 0000305}. # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR01727 oligo_HPY # eggNOG COG0444 LUCA # eggNOG ENOG4105C3U Bacteria BLAST swissprot:DPPD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DPPD_ECOLI BioCyc ECOL316407:JW3510-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3510-MONOMER BioCyc EcoCyc:DPPD-MONOMER http://biocyc.org/getid?id=EcoCyc:DPPD-MONOMER BioCyc MetaCyc:DPPD-MONOMER http://biocyc.org/getid?id=MetaCyc:DPPD-MONOMER COG COG0444 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0444 DIP DIP-47940N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47940N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1111/j.1365-2958.1994.tb01340.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb01340.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L08399 http://www.ebi.ac.uk/ena/data/view/L08399 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2511 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2511 EcoGene EG12627 http://www.ecogene.org/geneInfo.php?eg_id=EG12627 EnsemblBacteria AAC76566 http://www.ensemblgenomes.org/id/AAC76566 EnsemblBacteria AAC76566 http://www.ensemblgenomes.org/id/AAC76566 EnsemblBacteria BAE77753 http://www.ensemblgenomes.org/id/BAE77753 EnsemblBacteria BAE77753 http://www.ensemblgenomes.org/id/BAE77753 EnsemblBacteria BAE77753 http://www.ensemblgenomes.org/id/BAE77753 EnsemblBacteria b3541 http://www.ensemblgenomes.org/id/b3541 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0015232 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015232 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_process GO:0015031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031 GO_process GO:0015833 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015833 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948065 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948065 InParanoid P0AAG0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAG0 IntAct P0AAG0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAG0* InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR013563 http://www.ebi.ac.uk/interpro/entry/IPR013563 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3510 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3510 KEGG_Gene eco:b3541 http://www.genome.jp/dbget-bin/www_bget?eco:b3541 KEGG_Orthology KO:K12371 http://www.genome.jp/dbget-bin/www_bget?KO:K12371 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 MINT MINT-1258246 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1258246 OMA QRKENMA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QRKENMA PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:DPPD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DPPD_ECOLI PSORT-B swissprot:DPPD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DPPD_ECOLI PSORT2 swissprot:DPPD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DPPD_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Pfam PF08352 http://pfam.xfam.org/family/PF08352 Phobius swissprot:DPPD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DPPD_ECOLI PhylomeDB P0AAG0 http://phylomedb.org/?seqid=P0AAG0 ProteinModelPortal P0AAG0 http://www.proteinmodelportal.org/query/uniprot/P0AAG0 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7536291 http://www.ncbi.nlm.nih.gov/pubmed/7536291 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417998 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417998 RefSeq WP_001196486 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001196486 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P0AAG0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAG0 STRING 511145.b3541 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3541&targetmode=cogs STRING COG0444 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0444&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR01727 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01727 UniProtKB DPPD_ECOLI http://www.uniprot.org/uniprot/DPPD_ECOLI UniProtKB-AC P0AAG0 http://www.uniprot.org/uniprot/P0AAG0 charge swissprot:DPPD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DPPD_ECOLI eggNOG COG0444 http://eggnogapi.embl.de/nog_data/html/tree/COG0444 eggNOG ENOG4105C3U http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C3U epestfind swissprot:DPPD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DPPD_ECOLI garnier swissprot:DPPD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DPPD_ECOLI helixturnhelix swissprot:DPPD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DPPD_ECOLI hmoment swissprot:DPPD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DPPD_ECOLI iep swissprot:DPPD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DPPD_ECOLI inforesidue swissprot:DPPD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DPPD_ECOLI octanol swissprot:DPPD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DPPD_ECOLI pepcoil swissprot:DPPD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DPPD_ECOLI pepdigest swissprot:DPPD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DPPD_ECOLI pepinfo swissprot:DPPD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DPPD_ECOLI pepnet swissprot:DPPD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DPPD_ECOLI pepstats swissprot:DPPD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DPPD_ECOLI pepwheel swissprot:DPPD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DPPD_ECOLI pepwindow swissprot:DPPD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DPPD_ECOLI sigcleave swissprot:DPPD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DPPD_ECOLI ## Database ID URL or Descriptions # BioGrid 4263478 4 # COFACTOR YJJW_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000250|UniProtKB P0A9N4}; Note=May bind up to 3 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L- methionine. {ECO 0000305}; # EcoGene EG12599 yjjW # GO_function GO:0016491 oxidoreductase activity; IEA:UniProtKB-KW. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # INTERACTION YJJW_ECOLI P0AEF4 dpiA; NbExp=2; IntAct=EBI-9132384, EBI-1119284; P09147 galE; NbExp=2; IntAct=EBI-9132384, EBI-909010; P18196 minC; NbExp=2; IntAct=EBI-9132384, EBI-554060; # IntAct P39409 25 # InterPro IPR001989 Radical_activat_CS # InterPro IPR007197 rSAM # InterPro IPR012839 Organic_radical_activase # InterPro IPR017896 4Fe4S_Fe-S-bd # InterPro IPR017900 4Fe4S_Fe_S_CS # InterPro IPR023912 YjjW_bact # Organism YJJW_ECOLI Escherichia coli (strain K12) # PATRIC 32124370 VBIEscCol129921_4525 # PIR S56603 S56603 # PIRSF PIRSF000371 PFL_act_enz # PROSITE PS00198 4FE4S_FER_1; 2 # PROSITE PS01087 RADICAL_ACTIVATING # PROSITE PS51379 4FE4S_FER_2; 2 # Pfam PF04055 Radical_SAM # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Putative glycyl-radical enzyme activating enzyme YjjW {ECO 0000305} # RefSeq NP_418796 NC_000913.3 # RefSeq WP_001088415 NZ_LN832404.1 # SIMILARITY Belongs to the organic radical-activating enzymes family. {ECO 0000305}. # SIMILARITY Contains 2 4Fe-4S ferredoxin-type domains. {ECO:0000255|PROSITE-ProRule PRU00711}. # TIGRFAMs TIGR04041 activase_YjjW # eggNOG COG1180 LUCA # eggNOG ENOG41076CZ Bacteria BLAST swissprot:YJJW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJJW_ECOLI BioCyc ECOL316407:JW4342-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4342-MONOMER BioCyc EcoCyc:G7953-MONOMER http://biocyc.org/getid?id=EcoCyc:G7953-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.97.1.- {ECO:0000305} http://www.genome.jp/dbget-bin/www_bget?EC:1.97.1.- {ECO:0000305} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 1.97.1.- {ECO:0000305} http://enzyme.expasy.org/EC/1.97.1.- {ECO:0000305} EchoBASE EB2484 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2484 EcoGene EG12599 http://www.ecogene.org/geneInfo.php?eg_id=EG12599 EnsemblBacteria AAC77332 http://www.ensemblgenomes.org/id/AAC77332 EnsemblBacteria AAC77332 http://www.ensemblgenomes.org/id/AAC77332 EnsemblBacteria BAE78368 http://www.ensemblgenomes.org/id/BAE78368 EnsemblBacteria BAE78368 http://www.ensemblgenomes.org/id/BAE78368 EnsemblBacteria BAE78368 http://www.ensemblgenomes.org/id/BAE78368 EnsemblBacteria b4379 http://www.ensemblgenomes.org/id/b4379 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GeneID 948905 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948905 HOGENOM HOG000011457 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000011457&db=HOGENOM6 InParanoid P39409 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39409 IntAct P39409 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39409* IntEnz 1.97.1.- {ECO:0000305} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.97.1.- {ECO:0000305} InterPro IPR001989 http://www.ebi.ac.uk/interpro/entry/IPR001989 InterPro IPR007197 http://www.ebi.ac.uk/interpro/entry/IPR007197 InterPro IPR012839 http://www.ebi.ac.uk/interpro/entry/IPR012839 InterPro IPR017896 http://www.ebi.ac.uk/interpro/entry/IPR017896 InterPro IPR017900 http://www.ebi.ac.uk/interpro/entry/IPR017900 InterPro IPR023912 http://www.ebi.ac.uk/interpro/entry/IPR023912 KEGG_Gene ecj:JW4342 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4342 KEGG_Gene eco:b4379 http://www.genome.jp/dbget-bin/www_bget?eco:b4379 OMA CHEVNIH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CHEVNIH PROSITE PS00198 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00198 PROSITE PS01087 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01087 PROSITE PS51379 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51379 PSORT swissprot:YJJW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJJW_ECOLI PSORT-B swissprot:YJJW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJJW_ECOLI PSORT2 swissprot:YJJW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJJW_ECOLI Pfam PF04055 http://pfam.xfam.org/family/PF04055 Phobius swissprot:YJJW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJJW_ECOLI PhylomeDB P39409 http://phylomedb.org/?seqid=P39409 ProteinModelPortal P39409 http://www.proteinmodelportal.org/query/uniprot/P39409 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418796 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418796 RefSeq WP_001088415 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001088415 SMR P39409 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39409 STRING 511145.b4379 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4379&targetmode=cogs TIGRFAMs TIGR04041 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR04041 UniProtKB YJJW_ECOLI http://www.uniprot.org/uniprot/YJJW_ECOLI UniProtKB-AC P39409 http://www.uniprot.org/uniprot/P39409 charge swissprot:YJJW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJJW_ECOLI eggNOG COG1180 http://eggnogapi.embl.de/nog_data/html/tree/COG1180 eggNOG ENOG41076CZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG41076CZ epestfind swissprot:YJJW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJJW_ECOLI garnier swissprot:YJJW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJJW_ECOLI helixturnhelix swissprot:YJJW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJJW_ECOLI hmoment swissprot:YJJW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJJW_ECOLI iep swissprot:YJJW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJJW_ECOLI inforesidue swissprot:YJJW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJJW_ECOLI octanol swissprot:YJJW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJJW_ECOLI pepcoil swissprot:YJJW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJJW_ECOLI pepdigest swissprot:YJJW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJJW_ECOLI pepinfo swissprot:YJJW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJJW_ECOLI pepnet swissprot:YJJW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJJW_ECOLI pepstats swissprot:YJJW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJJW_ECOLI pepwheel swissprot:YJJW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJJW_ECOLI pepwindow swissprot:YJJW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJJW_ECOLI sigcleave swissprot:YJJW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJJW_ECOLI ## Database ID URL or Descriptions # BRENDA 4.1.99.12 2026 # BioGrid 4260672 13 # CATALYTIC ACTIVITY RIBB_ECOLI D-ribulose 5-phosphate = formate + L-3,4- dihydroxybutan-2-one 4-phosphate. # COFACTOR RIBB_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 11687623}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 11687623}; Note=Binds 2 divalent metal cations per subunit. Magnesium or manganese. {ECO 0000269|PubMed 11687623}; # EcoGene EG10465 ribB # FUNCTION RIBB_ECOLI Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0008686 3,4-dihydroxy-2-butanone-4-phosphate synthase activity; IDA:EcoCyc. # GO_function GO:0030145 manganese ion binding; IEA:UniProtKB-HAMAP. # GO_process GO:0009231 riboflavin biosynthetic process; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.90.870.10 -; 1. # HAMAP MF_00180 RibB # INDUCTION RIBB_ECOLI Is expressed at all temperatures, but accumulation of transcripts decline with raising temperature. Thus, its expression is repressed by heat shock. # INTERACTION RIBB_ECOLI Self; NbExp=4; IntAct=EBI-553653, EBI-553653; # IntAct P0A7J0 26 # InterPro IPR000422 DHBP_synthase_RibB # InterPro IPR017945 DHBP_synth_RibB-like_a/b_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00740 Riboflavin metabolism # MASS SPECTROMETRY Mass=23352; Mass_error=2; Method=Electrospray; Range=1-217; Evidence={ECO:0000269|PubMed 1597419}; # Organism RIBB_ECOLI Escherichia coli (strain K12) # PATHWAY Cofactor biosynthesis; riboflavin biosynthesis; 2- hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate step 1/1. # PATRIC 32121494 VBIEscCol129921_3134 # PDB 1G57 X-ray; 1.40 A; A/B=3-217 # PDB 1G58 X-ray; 1.55 A; A/B=3-217 # PDB 1IEZ NMR; -; A=1-217 # PIR A38159 A38159 # Pfam PF00926 DHBP_synthase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RIBB_ECOLI 3,4-dihydroxy-2-butanone 4-phosphate synthase # RefSeq NP_417513 NC_000913.3 # RefSeq WP_001076997 NZ_LN832404.1 # SIMILARITY Belongs to the DHBP synthase family. {ECO 0000305}. # SUBCELLULAR LOCATION RIBB_ECOLI Cell membrane {ECO 0000305}; Peripheral membrane protein {ECO 0000305}. # SUBUNIT RIBB_ECOLI Homodimer. {ECO 0000269|PubMed 11342130, ECO 0000269|PubMed 11687623}. # SUPFAM SSF55821 SSF55821 # TIGRFAMs TIGR00506 ribB # UniPathway UPA00275 UER00399 # eggNOG COG0108 LUCA # eggNOG ENOG4105C66 Bacteria BLAST swissprot:RIBB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RIBB_ECOLI BioCyc ECOL316407:JW3009-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3009-MONOMER BioCyc EcoCyc:DIOHBUTANONEPSYN-MONOMER http://biocyc.org/getid?id=EcoCyc:DIOHBUTANONEPSYN-MONOMER BioCyc MetaCyc:DIOHBUTANONEPSYN-MONOMER http://biocyc.org/getid?id=MetaCyc:DIOHBUTANONEPSYN-MONOMER COG COG0108 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0108 DIP DIP-35934N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35934N DOI 10.1016/0167-4781(92)90535-8 http://dx.doi.org/10.1016/0167-4781(92)90535-8 DOI 10.1016/S0969-2126(00)00550-5 http://dx.doi.org/10.1016/S0969-2126(00)00550-5 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.231323598 http://dx.doi.org/10.1073/pnas.231323598 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.1.99.12 http://www.genome.jp/dbget-bin/www_bget?EC:4.1.99.12 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M64472 http://www.ebi.ac.uk/ena/data/view/M64472 EMBL M77129 http://www.ebi.ac.uk/ena/data/view/M77129 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EMBL X66720 http://www.ebi.ac.uk/ena/data/view/X66720 ENZYME 4.1.99.12 http://enzyme.expasy.org/EC/4.1.99.12 EchoBASE EB0460 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0460 EcoGene EG10465 http://www.ecogene.org/geneInfo.php?eg_id=EG10465 EnsemblBacteria AAC76077 http://www.ensemblgenomes.org/id/AAC76077 EnsemblBacteria AAC76077 http://www.ensemblgenomes.org/id/AAC76077 EnsemblBacteria BAE77097 http://www.ensemblgenomes.org/id/BAE77097 EnsemblBacteria BAE77097 http://www.ensemblgenomes.org/id/BAE77097 EnsemblBacteria BAE77097 http://www.ensemblgenomes.org/id/BAE77097 EnsemblBacteria b3041 http://www.ensemblgenomes.org/id/b3041 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0008686 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008686 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_process GO:0009231 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009231 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.90.870.10 http://www.cathdb.info/version/latest/superfamily/3.90.870.10 GeneID 947526 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947526 HAMAP MF_00180 http://hamap.expasy.org/unirule/MF_00180 HOGENOM HOG000115444 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000115444&db=HOGENOM6 InParanoid P0A7J0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7J0 IntAct P0A7J0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7J0* IntEnz 4.1.99.12 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.99.12 InterPro IPR000422 http://www.ebi.ac.uk/interpro/entry/IPR000422 InterPro IPR017945 http://www.ebi.ac.uk/interpro/entry/IPR017945 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3009 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3009 KEGG_Gene eco:b3041 http://www.genome.jp/dbget-bin/www_bget?eco:b3041 KEGG_Orthology KO:K02858 http://www.genome.jp/dbget-bin/www_bget?KO:K02858 KEGG_Pathway ko00740 http://www.genome.jp/kegg-bin/show_pathway?ko00740 KEGG_Reaction rn:R07281 http://www.genome.jp/dbget-bin/www_bget?rn:R07281 MINT MINT-1239671 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1239671 OMA QMAKLIR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QMAKLIR PDB 1G57 http://www.ebi.ac.uk/pdbe-srv/view/entry/1G57 PDB 1G58 http://www.ebi.ac.uk/pdbe-srv/view/entry/1G58 PDB 1IEZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1IEZ PDBsum 1G57 http://www.ebi.ac.uk/pdbsum/1G57 PDBsum 1G58 http://www.ebi.ac.uk/pdbsum/1G58 PDBsum 1IEZ http://www.ebi.ac.uk/pdbsum/1IEZ PSORT swissprot:RIBB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RIBB_ECOLI PSORT-B swissprot:RIBB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RIBB_ECOLI PSORT2 swissprot:RIBB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RIBB_ECOLI Pfam PF00926 http://pfam.xfam.org/family/PF00926 Phobius swissprot:RIBB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RIBB_ECOLI PhylomeDB P0A7J0 http://phylomedb.org/?seqid=P0A7J0 ProteinModelPortal P0A7J0 http://www.proteinmodelportal.org/query/uniprot/P0A7J0 PubMed 11342130 http://www.ncbi.nlm.nih.gov/pubmed/11342130 PubMed 11687623 http://www.ncbi.nlm.nih.gov/pubmed/11687623 PubMed 1314093 http://www.ncbi.nlm.nih.gov/pubmed/1314093 PubMed 1597419 http://www.ncbi.nlm.nih.gov/pubmed/1597419 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1917833 http://www.ncbi.nlm.nih.gov/pubmed/1917833 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417513 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417513 RefSeq WP_001076997 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001076997 SMR P0A7J0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7J0 STRING 511145.b3041 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3041&targetmode=cogs STRING COG0108 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0108&targetmode=cogs SUPFAM SSF55821 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55821 TIGRFAMs TIGR00506 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00506 UniProtKB RIBB_ECOLI http://www.uniprot.org/uniprot/RIBB_ECOLI UniProtKB-AC P0A7J0 http://www.uniprot.org/uniprot/P0A7J0 charge swissprot:RIBB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RIBB_ECOLI eggNOG COG0108 http://eggnogapi.embl.de/nog_data/html/tree/COG0108 eggNOG ENOG4105C66 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C66 epestfind swissprot:RIBB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RIBB_ECOLI garnier swissprot:RIBB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RIBB_ECOLI helixturnhelix swissprot:RIBB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RIBB_ECOLI hmoment swissprot:RIBB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RIBB_ECOLI iep swissprot:RIBB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RIBB_ECOLI inforesidue swissprot:RIBB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RIBB_ECOLI octanol swissprot:RIBB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RIBB_ECOLI pepcoil swissprot:RIBB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RIBB_ECOLI pepdigest swissprot:RIBB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RIBB_ECOLI pepinfo swissprot:RIBB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RIBB_ECOLI pepnet swissprot:RIBB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RIBB_ECOLI pepstats swissprot:RIBB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RIBB_ECOLI pepwheel swissprot:RIBB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RIBB_ECOLI pepwindow swissprot:RIBB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RIBB_ECOLI sigcleave swissprot:RIBB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RIBB_ECOLI ## Database ID URL or Descriptions # AltName Acyl-ACP phosphotransacylase {ECO:0000255|HAMAP-Rule MF_00019} # AltName Acyl-[acyl-carrier-protein]--phosphate acyltransferase {ECO:0000255|HAMAP-Rule MF_00019} # AltName Phosphate-acyl-ACP acyltransferase {ECO:0000255|HAMAP-Rule MF_00019} # BioGrid 4261030 142 # CATALYTIC ACTIVITY Acyl-[acyl-carrier-protein] + phosphate = acyl-phosphate + [acyl-carrier-protein]. {ECO:0000255|HAMAP- Rule MF_00019}. # EcoGene EG11437 plsX # FUNCTION PLSX_ECOLI Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. {ECO 0000255|HAMAP-Rule MF_00019, ECO 0000269|PubMed 17645809}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0004147 dihydrolipoamide branched chain acyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0008951 palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016406 carnitine O-acyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016411 acylglycerol O-acyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016412 serine O-acyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016413 O-acetyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016414 O-octanoyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016416 O-palmitoyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016418 S-acetyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016419 S-malonyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016454 C-palmitoyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro. # GO_function GO:0016749 N-succinyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016750 O-succinyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016751 S-succinyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016753 O-sinapoyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0018030 peptidyl-lysine N6-myristoyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0018031 peptidyl-lysine N6-palmitoyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0018711 benzoyl acetate-CoA thiolase activity; IEA:UniProtKB-EC. # GO_function GO:0018712 3-hydroxybutyryl-CoA thiolase activity; IEA:UniProtKB-EC. # GO_function GO:0018713 3-ketopimelyl-CoA thiolase activity; IEA:UniProtKB-EC. # GO_function GO:0019186 acyl-CoA N-acyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0019705 protein-cysteine S-myristoyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0032216 glucosaminyl-phosphotidylinositol O-acyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0034737 ergosterol O-acyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0034738 lanosterol O-acyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0034848 naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity; IEA:UniProtKB-EC. # GO_function GO:0034851 2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity; IEA:UniProtKB-EC. # GO_function GO:0034915 2-methylhexanoyl-CoA C-acetyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0034919 butyryl-CoA 2-C-propionyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0034945 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0043741 L-2-aminoadipate N-acetyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0043806 keto acid formate lyase activity; IEA:UniProtKB-EC. # GO_function GO:0043849 Ras palmitoyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0046941 azetidine-2-carboxylic acid acetyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0052858 peptidyl-lysine acetyltransferase activity; IEA:UniProtKB-EC. # GO_function PLSX_ECOLI GO 0090595 acetyl-CoA L-lysine N6-acetyltransferase; IEA UniProtKB-EC. # GO_process GO:0006633 fatty acid biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0008654 phospholipid biosynthetic process; IGI:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.718.10 -; 1. # HAMAP MF_00019 PlsX # InterPro IPR003664 FA_synthesis # InterPro IPR012281 Phospholipid_synth_PlsX-like # InterPro IPR024084 IsoPropMal-DH-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01004 Lipid biosynthesis proteins # KEGG_Pathway ko00561 Glycerolipid metabolism # KEGG_Pathway ko00564 Glycerophospholipid metabolism # Organism PLSX_ECOLI Escherichia coli (strain K12) # PATHWAY Lipid metabolism; phospholipid metabolism. {ECO:0000255|HAMAP-Rule MF_00019}. # PATRIC 32117421 VBIEscCol129921_1133 # PIR G64852 G64852 # PIRSF PIRSF002465 Phsphlp_syn_PlsX # Pfam PF02504 FA_synthesis # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Phosphate acyltransferase {ECO:0000255|HAMAP-Rule MF_00019} # RefSeq NP_415608 NC_000913.3 # RefSeq WP_014639043 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB59064.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the PlsX family. {ECO:0000255|HAMAP- Rule MF_00019}. # SUBCELLULAR LOCATION PLSX_ECOLI Cytoplasm. Note=Associated with the membrane possibly through PlsY. {ECO 0000305}. # SUBUNIT Homodimer. Probably interacts with PlsY. {ECO:0000255|HAMAP-Rule MF_00019}. # TIGRFAMs TIGR00182 plsX # eggNOG COG0416 LUCA # eggNOG ENOG4105C6B Bacteria BLAST swissprot:PLSX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PLSX_ECOLI BioCyc ECOL316407:JW5156-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5156-MONOMER BioCyc EcoCyc:EG11437-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11437-MONOMER COG COG0416 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0416 DIP DIP-10517N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10517N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1186/1471-2180-7-69 http://dx.doi.org/10.1186/1471-2180-7-69 EC_number EC:2.3.1.n2 {ECO:0000255|HAMAP-Rule:MF_00019} http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.n2 {ECO:0000255|HAMAP-Rule:MF_00019} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M96793 http://www.ebi.ac.uk/ena/data/view/M96793 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.3.1.n2 {ECO:0000255|HAMAP-Rule:MF_00019} http://enzyme.expasy.org/EC/2.3.1.n2 {ECO:0000255|HAMAP-Rule:MF_00019} EchoBASE EB1407 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1407 EcoGene EG11437 http://www.ecogene.org/geneInfo.php?eg_id=EG11437 EnsemblBacteria AAC74174 http://www.ensemblgenomes.org/id/AAC74174 EnsemblBacteria AAC74174 http://www.ensemblgenomes.org/id/AAC74174 EnsemblBacteria BAA35898 http://www.ensemblgenomes.org/id/BAA35898 EnsemblBacteria BAA35898 http://www.ensemblgenomes.org/id/BAA35898 EnsemblBacteria BAA35898 http://www.ensemblgenomes.org/id/BAA35898 EnsemblBacteria b1090 http://www.ensemblgenomes.org/id/b1090 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004147 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004147 GO_function GO:0008951 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008951 GO_function GO:0016406 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016406 GO_function GO:0016411 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016411 GO_function GO:0016412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016412 GO_function GO:0016413 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016413 GO_function GO:0016414 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016414 GO_function GO:0016416 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016416 GO_function GO:0016418 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016418 GO_function GO:0016419 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016419 GO_function GO:0016454 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016454 GO_function GO:0016616 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016616 GO_function GO:0016749 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016749 GO_function GO:0016750 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016750 GO_function GO:0016751 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016751 GO_function GO:0016753 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016753 GO_function GO:0018030 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018030 GO_function GO:0018031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018031 GO_function GO:0018711 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018711 GO_function GO:0018712 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018712 GO_function GO:0018713 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018713 GO_function GO:0019186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019186 GO_function GO:0019705 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019705 GO_function GO:0032216 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032216 GO_function GO:0034737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034737 GO_function GO:0034738 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034738 GO_function GO:0034848 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034848 GO_function GO:0034851 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034851 GO_function GO:0034915 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034915 GO_function GO:0034919 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034919 GO_function GO:0034945 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034945 GO_function GO:0043741 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043741 GO_function GO:0043806 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043806 GO_function GO:0043849 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043849 GO_function GO:0046941 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046941 GO_function GO:0052858 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052858 GO_function GO:0090595 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090595 GO_process GO:0006633 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006633 GO_process GO:0008654 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008654 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.718.10 http://www.cathdb.info/version/latest/superfamily/3.40.718.10 GeneID 946165 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946165 HAMAP MF_00019 http://hamap.expasy.org/unirule/MF_00019 HOGENOM HOG000154730 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000154730&db=HOGENOM6 InParanoid P27247 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P27247 IntAct P27247 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P27247* IntEnz 2.3.1.n2 {ECO:0000255|HAMAP-Rule:MF_00019} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.n2 {ECO:0000255|HAMAP-Rule:MF_00019} InterPro IPR003664 http://www.ebi.ac.uk/interpro/entry/IPR003664 InterPro IPR012281 http://www.ebi.ac.uk/interpro/entry/IPR012281 InterPro IPR024084 http://www.ebi.ac.uk/interpro/entry/IPR024084 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01004 http://www.genome.jp/dbget-bin/www_bget?ko01004 KEGG_Gene ecj:JW5156 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5156 KEGG_Gene eco:b1090 http://www.genome.jp/dbget-bin/www_bget?eco:b1090 KEGG_Orthology KO:K03621 http://www.genome.jp/dbget-bin/www_bget?KO:K03621 KEGG_Pathway ko00561 http://www.genome.jp/kegg-bin/show_pathway?ko00561 KEGG_Pathway ko00564 http://www.genome.jp/kegg-bin/show_pathway?ko00564 KEGG_Reaction rn:R00851 http://www.genome.jp/dbget-bin/www_bget?rn:R00851 KEGG_Reaction rn:R09380 http://www.genome.jp/dbget-bin/www_bget?rn:R09380 OMA IKGIERP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IKGIERP PSORT swissprot:PLSX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PLSX_ECOLI PSORT-B swissprot:PLSX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PLSX_ECOLI PSORT2 swissprot:PLSX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PLSX_ECOLI Pfam PF02504 http://pfam.xfam.org/family/PF02504 Phobius swissprot:PLSX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PLSX_ECOLI PhylomeDB P27247 http://phylomedb.org/?seqid=P27247 ProteinModelPortal P27247 http://www.proteinmodelportal.org/query/uniprot/P27247 PubMed 1447160 http://www.ncbi.nlm.nih.gov/pubmed/1447160 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17645809 http://www.ncbi.nlm.nih.gov/pubmed/17645809 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415608 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415608 RefSeq WP_014639043 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_014639043 SMR P27247 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P27247 STRING 511145.b1090 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1090&targetmode=cogs STRING COG0416 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0416&targetmode=cogs TIGRFAMs TIGR00182 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00182 UniProtKB PLSX_ECOLI http://www.uniprot.org/uniprot/PLSX_ECOLI UniProtKB-AC P27247 http://www.uniprot.org/uniprot/P27247 charge swissprot:PLSX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PLSX_ECOLI eggNOG COG0416 http://eggnogapi.embl.de/nog_data/html/tree/COG0416 eggNOG ENOG4105C6B http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C6B epestfind swissprot:PLSX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PLSX_ECOLI garnier swissprot:PLSX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PLSX_ECOLI helixturnhelix swissprot:PLSX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PLSX_ECOLI hmoment swissprot:PLSX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PLSX_ECOLI iep swissprot:PLSX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PLSX_ECOLI inforesidue swissprot:PLSX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PLSX_ECOLI octanol swissprot:PLSX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PLSX_ECOLI pepcoil swissprot:PLSX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PLSX_ECOLI pepdigest swissprot:PLSX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PLSX_ECOLI pepinfo swissprot:PLSX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PLSX_ECOLI pepnet swissprot:PLSX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PLSX_ECOLI pepstats swissprot:PLSX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PLSX_ECOLI pepwheel swissprot:PLSX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PLSX_ECOLI pepwindow swissprot:PLSX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PLSX_ECOLI sigcleave swissprot:PLSX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PLSX_ECOLI ## Database ID URL or Descriptions # BioGrid 4262686 12 # EcoGene EG11230 melR # FUNCTION MELR_ECOLI Transcription activator for the expression of the melAB operon. MelR binds at two sites located upstream of the melAB transcription site. {ECO 0000269|PubMed 2684786}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0000987 core promoter proximal region sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IBA:GO_Central. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.60 -; 2. # Gene3D 2.60.120.10 -; 1. # IntAct P0ACH8 14 # InterPro IPR008917 TF_DNA-bd # InterPro IPR009057 Homeodomain-like # InterPro IPR011051 RmlC_Cupin # InterPro IPR014710 RmlC-like_jellyroll # InterPro IPR018060 HTH_AraC # InterPro IPR018062 HTH_AraC-typ_CS # InterPro IPR020449 Tscrpt_reg_HTH_AraC-type # Organism MELR_ECOLI Escherichia coli (strain K12) # PATRIC 32123801 VBIEscCol129921_4249 # PIR A29625 RGECMB # PRINTS PR00032 HTHARAC # PROSITE PS00041 HTH_ARAC_FAMILY_1 # PROSITE PS01124 HTH_ARAC_FAMILY_2 # Pfam PF12833 HTH_18 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MELR_ECOLI Melibiose operon regulatory protein # RefSeq NP_418542 NC_000913.3 # RefSeq WP_001090758 NZ_LN832404.1 # SIMILARITY Contains 1 HTH araC/xylS-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00593}. # SMART SM00342 HTH_ARAC # SUPFAM SSF46689 SSF46689 # SUPFAM SSF47454 SSF47454 # SUPFAM SSF51182 SSF51182 # eggNOG ENOG4108K2B Bacteria # eggNOG ENOG410XP2B LUCA BLAST swissprot:MELR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MELR_ECOLI BioCyc ECOL316407:JW4079-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4079-MONOMER BioCyc EcoCyc:PD00208 http://biocyc.org/getid?id=EcoCyc:PD00208 DIP DIP-10181N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10181N DOI 10.1016/0378-1119(87)90333-7 http://dx.doi.org/10.1016/0378-1119(87)90333-7 DOI 10.1016/0378-1119(89)90106-6 http://dx.doi.org/10.1016/0378-1119(89)90106-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2870493 http://dx.doi.org/10.1042/bj2870493 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1093/nar/25.9.1685 http://dx.doi.org/10.1093/nar/25.9.1685 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M18425 http://www.ebi.ac.uk/ena/data/view/M18425 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB1212 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1212 EcoGene EG11230 http://www.ecogene.org/geneInfo.php?eg_id=EG11230 EnsemblBacteria AAC77079 http://www.ensemblgenomes.org/id/AAC77079 EnsemblBacteria AAC77079 http://www.ensemblgenomes.org/id/AAC77079 EnsemblBacteria BAE78120 http://www.ensemblgenomes.org/id/BAE78120 EnsemblBacteria BAE78120 http://www.ensemblgenomes.org/id/BAE78120 EnsemblBacteria BAE78120 http://www.ensemblgenomes.org/id/BAE78120 EnsemblBacteria b4118 http://www.ensemblgenomes.org/id/b4118 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000987 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000987 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 Gene3D 2.60.120.10 http://www.cathdb.info/version/latest/superfamily/2.60.120.10 GeneID 948637 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948637 HOGENOM HOG000127063 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000127063&db=HOGENOM6 InParanoid P0ACH8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACH8 IntAct P0ACH8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACH8* InterPro IPR008917 http://www.ebi.ac.uk/interpro/entry/IPR008917 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR011051 http://www.ebi.ac.uk/interpro/entry/IPR011051 InterPro IPR014710 http://www.ebi.ac.uk/interpro/entry/IPR014710 InterPro IPR018060 http://www.ebi.ac.uk/interpro/entry/IPR018060 InterPro IPR018062 http://www.ebi.ac.uk/interpro/entry/IPR018062 InterPro IPR020449 http://www.ebi.ac.uk/interpro/entry/IPR020449 KEGG_Gene ecj:JW4079 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4079 KEGG_Gene eco:b4118 http://www.genome.jp/dbget-bin/www_bget?eco:b4118 OMA MCLFWGG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MCLFWGG PRINTS PR00032 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00032 PROSITE PS00041 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00041 PROSITE PS01124 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01124 PSORT swissprot:MELR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MELR_ECOLI PSORT-B swissprot:MELR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MELR_ECOLI PSORT2 swissprot:MELR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MELR_ECOLI Pfam PF12833 http://pfam.xfam.org/family/PF12833 Phobius swissprot:MELR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MELR_ECOLI PhylomeDB P0ACH8 http://phylomedb.org/?seqid=P0ACH8 ProteinModelPortal P0ACH8 http://www.proteinmodelportal.org/query/uniprot/P0ACH8 PubMed 1445207 http://www.ncbi.nlm.nih.gov/pubmed/1445207 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2684786 http://www.ncbi.nlm.nih.gov/pubmed/2684786 PubMed 2830169 http://www.ncbi.nlm.nih.gov/pubmed/2830169 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9108148 http://www.ncbi.nlm.nih.gov/pubmed/9108148 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418542 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418542 RefSeq WP_001090758 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001090758 SMART SM00342 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00342 SMR P0ACH8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACH8 STRING 511145.b4118 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4118&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF47454 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47454 SUPFAM SSF51182 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51182 UniProtKB MELR_ECOLI http://www.uniprot.org/uniprot/MELR_ECOLI UniProtKB-AC P0ACH8 http://www.uniprot.org/uniprot/P0ACH8 charge swissprot:MELR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MELR_ECOLI eggNOG ENOG4108K2B http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108K2B eggNOG ENOG410XP2B http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XP2B epestfind swissprot:MELR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MELR_ECOLI garnier swissprot:MELR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MELR_ECOLI helixturnhelix swissprot:MELR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MELR_ECOLI hmoment swissprot:MELR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MELR_ECOLI iep swissprot:MELR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MELR_ECOLI inforesidue swissprot:MELR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MELR_ECOLI octanol swissprot:MELR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MELR_ECOLI pepcoil swissprot:MELR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MELR_ECOLI pepdigest swissprot:MELR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MELR_ECOLI pepinfo swissprot:MELR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MELR_ECOLI pepnet swissprot:MELR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MELR_ECOLI pepstats swissprot:MELR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MELR_ECOLI pepwheel swissprot:MELR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MELR_ECOLI pepwindow swissprot:MELR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MELR_ECOLI sigcleave swissprot:MELR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MELR_ECOLI ## Database ID URL or Descriptions # CDD cd00383 trans_reg_C # EcoGene EG11218 creB # FUNCTION CREB_ECOLI Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0000160 phosphorelay signal transduction system; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # INTERACTION CREB_ECOLI Self; NbExp=2; IntAct=EBI-1131567, EBI-1131567; # IntAct P08368 4 # InterPro IPR001789 Sig_transdc_resp-reg_receiver # InterPro IPR001867 OmpR/PhoB-type_DNA-bd # InterPro IPR011006 CheY-like_superfamily # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR016032 Sig_transdc_resp-reg_C-effctor # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02022 M00449 CreC-CreB (phosphate regulation) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # Organism CREB_ECOLI Escherichia coli (strain K12) # PATRIC 32124414 VBIEscCol129921_4547 # PIR B25038 QQECFJ # PROSITE PS50110 RESPONSE_REGULATORY # PROSITE PS51755 OMPR_PHOB # PTM CREB_ECOLI Phosphorylated by CreC. {ECO 0000269|PubMed 15522865}. # Pfam PF00072 Response_reg # Pfam PF00486 Trans_reg_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CREB_ECOLI Transcriptional regulatory protein CreB # RefSeq NP_418815 NC_000913.3 # RefSeq WP_001188654 NZ_LN832404.1 # SIMILARITY Contains 1 OmpR/PhoB-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU01091}. # SIMILARITY Contains 1 response regulatory domain. {ECO:0000255|PROSITE-ProRule PRU00169}. # SMART SM00448 REC # SMART SM00862 Trans_reg_C # SUBCELLULAR LOCATION CREB_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF46894 SSF46894 # SUPFAM SSF52172 SSF52172 # eggNOG COG0745 LUCA # eggNOG ENOG4105E3W Bacteria BLAST swissprot:CREB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CREB_ECOLI BioCyc ECOL316407:JW4361-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4361-MONOMER BioCyc EcoCyc:CREB-MONOMER http://biocyc.org/getid?id=EcoCyc:CREB-MONOMER COG COG0745 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0745 DIP DIP-9318N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9318N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M410104200 http://dx.doi.org/10.1074/jbc.M410104200 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M13608 http://www.ebi.ac.uk/ena/data/view/M13608 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB1201 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1201 EcoGene EG11218 http://www.ecogene.org/geneInfo.php?eg_id=EG11218 EnsemblBacteria AAC77351 http://www.ensemblgenomes.org/id/AAC77351 EnsemblBacteria AAC77351 http://www.ensemblgenomes.org/id/AAC77351 EnsemblBacteria BAE78387 http://www.ensemblgenomes.org/id/BAE78387 EnsemblBacteria BAE78387 http://www.ensemblgenomes.org/id/BAE78387 EnsemblBacteria BAE78387 http://www.ensemblgenomes.org/id/BAE78387 EnsemblBacteria b4398 http://www.ensemblgenomes.org/id/b4398 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 948922 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948922 HOGENOM HOG000034819 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000034819&db=HOGENOM6 InParanoid P08368 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P08368 IntAct P08368 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P08368* InterPro IPR001789 http://www.ebi.ac.uk/interpro/entry/IPR001789 InterPro IPR001867 http://www.ebi.ac.uk/interpro/entry/IPR001867 InterPro IPR011006 http://www.ebi.ac.uk/interpro/entry/IPR011006 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR016032 http://www.ebi.ac.uk/interpro/entry/IPR016032 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW4361 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4361 KEGG_Gene eco:b4398 http://www.genome.jp/dbget-bin/www_bget?eco:b4398 KEGG_Orthology KO:K07663 http://www.genome.jp/dbget-bin/www_bget?KO:K07663 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA HDEFEVD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HDEFEVD PROSITE PS50110 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50110 PROSITE PS51755 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51755 PSORT swissprot:CREB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CREB_ECOLI PSORT-B swissprot:CREB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CREB_ECOLI PSORT2 swissprot:CREB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CREB_ECOLI Pfam PF00072 http://pfam.xfam.org/family/PF00072 Pfam PF00486 http://pfam.xfam.org/family/PF00486 Phobius swissprot:CREB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CREB_ECOLI PhylomeDB P08368 http://phylomedb.org/?seqid=P08368 ProteinModelPortal P08368 http://www.proteinmodelportal.org/query/uniprot/P08368 PubMed 15522865 http://www.ncbi.nlm.nih.gov/pubmed/15522865 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3531171 http://www.ncbi.nlm.nih.gov/pubmed/3531171 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418815 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418815 RefSeq WP_001188654 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001188654 SMART SM00448 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00448 SMART SM00862 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00862 SMR P08368 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P08368 STRING 511145.b4398 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4398&targetmode=cogs STRING COG0745 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0745&targetmode=cogs SUPFAM SSF46894 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46894 SUPFAM SSF52172 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52172 UniProtKB CREB_ECOLI http://www.uniprot.org/uniprot/CREB_ECOLI UniProtKB-AC P08368 http://www.uniprot.org/uniprot/P08368 charge swissprot:CREB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CREB_ECOLI eggNOG COG0745 http://eggnogapi.embl.de/nog_data/html/tree/COG0745 eggNOG ENOG4105E3W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E3W epestfind swissprot:CREB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CREB_ECOLI garnier swissprot:CREB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CREB_ECOLI helixturnhelix swissprot:CREB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CREB_ECOLI hmoment swissprot:CREB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CREB_ECOLI iep swissprot:CREB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CREB_ECOLI inforesidue swissprot:CREB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CREB_ECOLI octanol swissprot:CREB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CREB_ECOLI pepcoil swissprot:CREB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CREB_ECOLI pepdigest swissprot:CREB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CREB_ECOLI pepinfo swissprot:CREB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CREB_ECOLI pepnet swissprot:CREB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CREB_ECOLI pepstats swissprot:CREB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CREB_ECOLI pepwheel swissprot:CREB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CREB_ECOLI pepwindow swissprot:CREB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CREB_ECOLI sigcleave swissprot:CREB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CREB_ECOLI ## Database ID URL or Descriptions # BioGrid 4261433 14 # EcoGene EG14221 perM # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0005215 transporter activity; IBA:GO_Central. # GO_process GO:0055085 transmembrane transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0055085 transmembrane transport # InterPro IPR002549 AI-2E-like # KEGG_Brite ko02000 Transporters # Organism PERM_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21716 PTHR21716 # PATRIC 32120373 VBIEscCol129921_2589 # PIR D65025 D65025 # Pfam PF01594 AI-2E_transport # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PERM_ECOLI Putative permease PerM # RefSeq NP_416988 NC_000913.3 # RefSeq WP_000892044 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0118 (PerM) family. {ECO 0000305}. # SUBCELLULAR LOCATION PERM_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # TCDB 2.A.86.1 the autoinducer-2 exporter (ai-2e) family (formerly the perm family, tc #9.b.22) # eggNOG COG0628 LUCA # eggNOG ENOG4105C02 Bacteria BLAST swissprot:PERM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PERM_ECOLI BioCyc ECOL316407:JW2478-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2478-MONOMER BioCyc EcoCyc:G7310-MONOMER http://biocyc.org/getid?id=EcoCyc:G7310-MONOMER COG COG0628 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0628 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M63654 http://www.ebi.ac.uk/ena/data/view/M63654 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3973 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3973 EcoGene EG14221 http://www.ecogene.org/geneInfo.php?eg_id=EG14221 EnsemblBacteria AAC75546 http://www.ensemblgenomes.org/id/AAC75546 EnsemblBacteria AAC75546 http://www.ensemblgenomes.org/id/AAC75546 EnsemblBacteria BAA16382 http://www.ensemblgenomes.org/id/BAA16382 EnsemblBacteria BAA16382 http://www.ensemblgenomes.org/id/BAA16382 EnsemblBacteria BAA16382 http://www.ensemblgenomes.org/id/BAA16382 EnsemblBacteria b2493 http://www.ensemblgenomes.org/id/b2493 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 945894 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945894 HOGENOM HOG000275836 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275836&db=HOGENOM6 InParanoid P0AFI9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFI9 IntAct P0AFI9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFI9* InterPro IPR002549 http://www.ebi.ac.uk/interpro/entry/IPR002549 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2478 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2478 KEGG_Gene eco:b2493 http://www.genome.jp/dbget-bin/www_bget?eco:b2493 KEGG_Orthology KO:K03548 http://www.genome.jp/dbget-bin/www_bget?KO:K03548 OMA MPVAWQQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MPVAWQQ PANTHER PTHR21716 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21716 PSORT swissprot:PERM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PERM_ECOLI PSORT-B swissprot:PERM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PERM_ECOLI PSORT2 swissprot:PERM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PERM_ECOLI Pfam PF01594 http://pfam.xfam.org/family/PF01594 Phobius swissprot:PERM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PERM_ECOLI PhylomeDB P0AFI9 http://phylomedb.org/?seqid=P0AFI9 ProteinModelPortal P0AFI9 http://www.proteinmodelportal.org/query/uniprot/P0AFI9 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416988 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416988 RefSeq WP_000892044 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000892044 STRING 511145.b2493 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2493&targetmode=cogs STRING COG0628 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0628&targetmode=cogs TCDB 2.A.86.1 http://www.tcdb.org/search/result.php?tc=2.A.86.1 UniProtKB PERM_ECOLI http://www.uniprot.org/uniprot/PERM_ECOLI UniProtKB-AC P0AFI9 http://www.uniprot.org/uniprot/P0AFI9 charge swissprot:PERM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PERM_ECOLI eggNOG COG0628 http://eggnogapi.embl.de/nog_data/html/tree/COG0628 eggNOG ENOG4105C02 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C02 epestfind swissprot:PERM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PERM_ECOLI garnier swissprot:PERM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PERM_ECOLI helixturnhelix swissprot:PERM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PERM_ECOLI hmoment swissprot:PERM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PERM_ECOLI iep swissprot:PERM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PERM_ECOLI inforesidue swissprot:PERM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PERM_ECOLI octanol swissprot:PERM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PERM_ECOLI pepcoil swissprot:PERM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PERM_ECOLI pepdigest swissprot:PERM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PERM_ECOLI pepinfo swissprot:PERM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PERM_ECOLI pepnet swissprot:PERM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PERM_ECOLI pepstats swissprot:PERM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PERM_ECOLI pepwheel swissprot:PERM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PERM_ECOLI pepwindow swissprot:PERM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PERM_ECOLI sigcleave swissprot:PERM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PERM_ECOLI ## Database ID URL or Descriptions # CAUTION PubMed:8905232 and PubMed 16738553 sequences differ from that shown due to the presence of an IS5 insertion element between codons 327 and 328. Strain W3110A but not W3110B harbors this IS5 insertion. {ECO:0000305}. # EcoGene EG13545 dcuC # FUNCTION DCUC_ECOLI Responsible for the transport of C4-dicarboxylates during anaerobic growth. {ECO 0000269|PubMed 10368146}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015556 C4-dicarboxylate transmembrane transporter activity; IEA:InterPro. # GO_process GO:0015740 C4-dicarboxylate transport; IGI:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR004669 C4_dicarb_anaerob_car # InterPro IPR018385 C4_dicarb_anaerob_car-like # KEGG_Brite ko02000 Transporters # Organism DCUC_ECOLI Escherichia coli (strain K12) # PATRIC 32116422 VBIEscCol129921_0651 # PIR C64796 C64796 # Pfam PF03606 DcuC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DCUC_ECOLI Anaerobic C4-dicarboxylate transporter DcuC # RefSeq NP_415154 NC_000913.3 # RefSeq WP_000955063 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA35263.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the DcuC/DcuD transporter (TC 2.A.61) family. {ECO 0000305}. # SUBCELLULAR LOCATION DCUC_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # TCDB 2.A.61.1 the c4-dicarboxylate uptake c (dcuc) family # TIGRFAMs TIGR00771 DcuC # eggNOG COG3069 LUCA # eggNOG ENOG4105CEE Bacteria BLAST swissprot:DCUC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DCUC_ECOLI BioCyc ECOL316407:JW0613-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0613-MONOMER BioCyc ECOL316407:JW0616-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0616-MONOMER BioCyc EcoCyc:DCUC-MONOMER http://biocyc.org/getid?id=EcoCyc:DCUC-MONOMER BioCyc MetaCyc:DCUC-MONOMER http://biocyc.org/getid?id=MetaCyc:DCUC-MONOMER COG COG3069 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3069 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EMBL X99112 http://www.ebi.ac.uk/ena/data/view/X99112 EchoBASE EB3315 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3315 EcoGene EG13545 http://www.ecogene.org/geneInfo.php?eg_id=EG13545 EnsemblBacteria AAC73722 http://www.ensemblgenomes.org/id/AAC73722 EnsemblBacteria AAC73722 http://www.ensemblgenomes.org/id/AAC73722 EnsemblBacteria BAA35263 http://www.ensemblgenomes.org/id/BAA35263 EnsemblBacteria BAA35263 http://www.ensemblgenomes.org/id/BAA35263 EnsemblBacteria BAA35263 http://www.ensemblgenomes.org/id/BAA35263 EnsemblBacteria BAA35264 http://www.ensemblgenomes.org/id/BAA35264 EnsemblBacteria BAA35264 http://www.ensemblgenomes.org/id/BAA35264 EnsemblBacteria BAA35264 http://www.ensemblgenomes.org/id/BAA35264 EnsemblBacteria b0621 http://www.ensemblgenomes.org/id/b0621 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015556 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015556 GO_process GO:0015740 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015740 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 945000 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945000 HOGENOM HOG000274996 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000274996&db=HOGENOM6 InterPro IPR004669 http://www.ebi.ac.uk/interpro/entry/IPR004669 InterPro IPR018385 http://www.ebi.ac.uk/interpro/entry/IPR018385 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0613 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0613 KEGG_Gene ecj:JW0616 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0616 KEGG_Gene eco:b0621 http://www.genome.jp/dbget-bin/www_bget?eco:b0621 KEGG_Orthology KO:K03326 http://www.genome.jp/dbget-bin/www_bget?KO:K03326 OMA DVAYRGM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DVAYRGM PSORT swissprot:DCUC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DCUC_ECOLI PSORT-B swissprot:DCUC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DCUC_ECOLI PSORT2 swissprot:DCUC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DCUC_ECOLI Pfam PF03606 http://pfam.xfam.org/family/PF03606 Phobius swissprot:DCUC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DCUC_ECOLI ProteinModelPortal P0ABP3 http://www.proteinmodelportal.org/query/uniprot/P0ABP3 PubMed 10368146 http://www.ncbi.nlm.nih.gov/pubmed/10368146 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 8955408 http://www.ncbi.nlm.nih.gov/pubmed/8955408 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415154 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415154 RefSeq WP_000955063 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000955063 STRING 511145.b0621 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0621&targetmode=cogs STRING COG3069 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3069&targetmode=cogs TCDB 2.A.61.1 http://www.tcdb.org/search/result.php?tc=2.A.61.1 TIGRFAMs TIGR00771 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00771 UniProtKB DCUC_ECOLI http://www.uniprot.org/uniprot/DCUC_ECOLI UniProtKB-AC P0ABP3 http://www.uniprot.org/uniprot/P0ABP3 charge swissprot:DCUC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DCUC_ECOLI eggNOG COG3069 http://eggnogapi.embl.de/nog_data/html/tree/COG3069 eggNOG ENOG4105CEE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CEE epestfind swissprot:DCUC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DCUC_ECOLI garnier swissprot:DCUC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DCUC_ECOLI helixturnhelix swissprot:DCUC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DCUC_ECOLI hmoment swissprot:DCUC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DCUC_ECOLI iep swissprot:DCUC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DCUC_ECOLI inforesidue swissprot:DCUC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DCUC_ECOLI octanol swissprot:DCUC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DCUC_ECOLI pepcoil swissprot:DCUC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DCUC_ECOLI pepdigest swissprot:DCUC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DCUC_ECOLI pepinfo swissprot:DCUC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DCUC_ECOLI pepnet swissprot:DCUC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DCUC_ECOLI pepstats swissprot:DCUC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DCUC_ECOLI pepwheel swissprot:DCUC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DCUC_ECOLI pepwindow swissprot:DCUC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DCUC_ECOLI sigcleave swissprot:DCUC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DCUC_ECOLI ## Database ID URL or Descriptions # BioGrid 4260036 13 # DISRUPTION PHENOTYPE Cells lacking this gene fail to grow on uridine as the sole source of nitrogen at room temperature indicating a probably accumulation of a toxic intermediate, the peracid aminoacrylate. {ECO:0000269|PubMed 20400551}. # EcoGene EG13857 rutC # FUNCTION RUTC_ECOLI May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce in vivo, but not in vitro in the pyrimidine nitrogen degradation. {ECO 0000269|PubMed 16540542}. # GO_function GO:0016491 oxidoreductase activity; IEA:UniProtKB-HAMAP. # GO_process GO:0006208 pyrimidine nucleobase catabolic process; IMP:EcoCyc. # GO_process GO:0006212 uracil catabolic process; IMP:UniProtKB. # GO_process GO:0019740 nitrogen utilization; IMP:UniProtKB. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.30.1330.40 -; 1. # HAMAP MF_00831 RutC # INDUCTION RUTC_ECOLI Up-regulated by the nitrogen regulatory protein C (NtrC also called GlnG) and repressed by RutR. {ECO 0000269|PubMed 11121068, ECO 0000269|PubMed 17919280}. # IntAct P0AFQ5 7 # InterPro IPR006175 YjgF/YER057c/UK114 # InterPro IPR013813 Endoribo_LPSP/chorism_mut-like # InterPro IPR019897 RidA_CS # InterPro IPR019898 RutC # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko00240 Pyrimidine metabolism # MISCELLANEOUS RUTC_ECOLI The Rut pathway degrades exogenous pyrimidines as the sole nitrogen source at room temperature but not at 37 degrees Celsius, a restriction that is apparently a consequence of an inadequate ability to remove toxic malonic semialdehyde at the higher temperature (RutE/YdfG function). # Organism RUTC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11803 PTHR11803 # PATRIC 32117249 VBIEscCol129921_1048 # PIR H64842 H64842 # PROSITE PS01094 UPF0076 # Pfam PF01042 Ribonuc_L-PSP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RUTC_ECOLI Putative aminoacrylate peracid reductase RutC # RefSeq NP_415530 NC_000913.3 # RefSeq WP_001126780 NZ_LN832404.1 # SIMILARITY Belongs to the RutC family. {ECO 0000305}. # SUBUNIT Homotrimer. {ECO 0000250}. # SUPFAM SSF55298 SSF55298 # TIGRFAMs TIGR03610 RutC # eggNOG COG0251 LUCA # eggNOG ENOG4107YYT Bacteria BLAST swissprot:RUTC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RUTC_ECOLI BioCyc ECOL316407:JW0995-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0995-MONOMER BioCyc EcoCyc:G6521-MONOMER http://biocyc.org/getid?id=EcoCyc:G6521-MONOMER COG COG0251 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0251 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0600521103 http://dx.doi.org/10.1073/pnas.0600521103 DOI 10.1073/pnas.97.26.14674 http://dx.doi.org/10.1073/pnas.97.26.14674 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.2007.05954.x http://dx.doi.org/10.1111/j.1365-2958.2007.05954.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00201-10 http://dx.doi.org/10.1128/JB.00201-10 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- EchoBASE EB3617 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3617 EcoGene EG13857 http://www.ecogene.org/geneInfo.php?eg_id=EG13857 EnsemblBacteria AAC74095 http://www.ensemblgenomes.org/id/AAC74095 EnsemblBacteria AAC74095 http://www.ensemblgenomes.org/id/AAC74095 EnsemblBacteria BAA35777 http://www.ensemblgenomes.org/id/BAA35777 EnsemblBacteria BAA35777 http://www.ensemblgenomes.org/id/BAA35777 EnsemblBacteria BAA35777 http://www.ensemblgenomes.org/id/BAA35777 EnsemblBacteria b1010 http://www.ensemblgenomes.org/id/b1010 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_process GO:0006208 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006208 GO_process GO:0006212 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006212 GO_process GO:0019740 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019740 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.30.1330.40 http://www.cathdb.info/version/latest/superfamily/3.30.1330.40 GeneID 945599 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945599 HAMAP MF_00831 http://hamap.expasy.org/unirule/MF_00831 HOGENOM HOG000267215 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267215&db=HOGENOM6 InParanoid P0AFQ5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFQ5 IntAct P0AFQ5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFQ5* IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR006175 http://www.ebi.ac.uk/interpro/entry/IPR006175 InterPro IPR013813 http://www.ebi.ac.uk/interpro/entry/IPR013813 InterPro IPR019897 http://www.ebi.ac.uk/interpro/entry/IPR019897 InterPro IPR019898 http://www.ebi.ac.uk/interpro/entry/IPR019898 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW0995 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0995 KEGG_Gene eco:b1010 http://www.genome.jp/dbget-bin/www_bget?eco:b1010 KEGG_Orthology KO:K09021 http://www.genome.jp/dbget-bin/www_bget?KO:K09021 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Reaction rn:R09982 http://www.genome.jp/dbget-bin/www_bget?rn:R09982 OMA TIITPPG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TIITPPG PANTHER PTHR11803 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11803 PROSITE PS01094 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01094 PSORT swissprot:RUTC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RUTC_ECOLI PSORT-B swissprot:RUTC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RUTC_ECOLI PSORT2 swissprot:RUTC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RUTC_ECOLI Pfam PF01042 http://pfam.xfam.org/family/PF01042 Phobius swissprot:RUTC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RUTC_ECOLI PhylomeDB P0AFQ5 http://phylomedb.org/?seqid=P0AFQ5 ProteinModelPortal P0AFQ5 http://www.proteinmodelportal.org/query/uniprot/P0AFQ5 PubMed 11121068 http://www.ncbi.nlm.nih.gov/pubmed/11121068 PubMed 16540542 http://www.ncbi.nlm.nih.gov/pubmed/16540542 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17919280 http://www.ncbi.nlm.nih.gov/pubmed/17919280 PubMed 20400551 http://www.ncbi.nlm.nih.gov/pubmed/20400551 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415530 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415530 RefSeq WP_001126780 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001126780 SMR P0AFQ5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFQ5 STRING 511145.b1010 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1010&targetmode=cogs STRING COG0251 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0251&targetmode=cogs SUPFAM SSF55298 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55298 TIGRFAMs TIGR03610 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03610 UniProtKB RUTC_ECOLI http://www.uniprot.org/uniprot/RUTC_ECOLI UniProtKB-AC P0AFQ5 http://www.uniprot.org/uniprot/P0AFQ5 charge swissprot:RUTC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RUTC_ECOLI eggNOG COG0251 http://eggnogapi.embl.de/nog_data/html/tree/COG0251 eggNOG ENOG4107YYT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107YYT epestfind swissprot:RUTC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RUTC_ECOLI garnier swissprot:RUTC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RUTC_ECOLI helixturnhelix swissprot:RUTC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RUTC_ECOLI hmoment swissprot:RUTC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RUTC_ECOLI iep swissprot:RUTC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RUTC_ECOLI inforesidue swissprot:RUTC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RUTC_ECOLI octanol swissprot:RUTC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RUTC_ECOLI pepcoil swissprot:RUTC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RUTC_ECOLI pepdigest swissprot:RUTC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RUTC_ECOLI pepinfo swissprot:RUTC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RUTC_ECOLI pepnet swissprot:RUTC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RUTC_ECOLI pepstats swissprot:RUTC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RUTC_ECOLI pepwheel swissprot:RUTC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RUTC_ECOLI pepwindow swissprot:RUTC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RUTC_ECOLI sigcleave swissprot:RUTC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RUTC_ECOLI ## Database ID URL or Descriptions # BioGrid 4261434 8 # COFACTOR BEPA_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000255|HAMAP-Rule MF_00997}; Note=Binds 1 zinc ion per subunit. {ECO 0000255|HAMAP- Rule MF_00997}; # DISRUPTION PHENOTYPE Disruption sensitizes cells to multiple drugs. {ECO:0000269|PubMed 24003122}. # ENZYME REGULATION Protease activity is inhibited by the metal chelating reagents 1,10-phenanthroline and EDTA. {ECO:0000269|PubMed 24003122}. # EcoGene EG14199 bepA # FUNCTION BEPA_ECOLI Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state. Promotes disulfide rearrangement of LptD during its biogenesis, and proteolytic degradation of LptD and BamA when their proper assembly is compromised. May facilitate membrane attachment of LoiP under unfavorable conditions. {ECO 0000255|HAMAP-Rule MF_00997, ECO 0000269|PubMed 22491786, ECO 0000269|PubMed 24003122}. # GO_component GO:0016020 membrane; IDA:EcoCyc. # GO_component GO:0030288 outer membrane-bounded periplasmic space; TAS:EcoCyc. # GO_function GO:0004222 metalloendopeptidase activity; IEA:InterPro. # GO_function GO:0008237 metallopeptidase activity; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IEA:UniProtKB-HAMAP. # GO_process GO:0061077 chaperone-mediated protein folding; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006457 protein folding # Gene3D 1.25.40.10 -; 1. # HAMAP MF_00997 Protease_BepA # IntAct P66948 3 # InterPro IPR001915 Peptidase_M48 # InterPro IPR011990 TPR-like_helical_dom # InterPro IPR030873 Protease_BepA # Organism BEPA_ECOLI Escherichia coli (strain K12) # PATRIC 32120375 VBIEscCol129921_2590 # PIR E65025 E65025 # Pfam PF01435 Peptidase_M48 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Beta-barrel assembly-enhancing protease {ECO:0000255|HAMAP-Rule MF_00997} # RefSeq NP_416989 NC_000913.3 # RefSeq WP_000489667 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase M48 family. BepA subfamily. {ECO:0000255|HAMAP-Rule MF_00997}. # SIMILARITY Contains 4 TPR repeats. {ECO:0000255|HAMAP- Rule MF_00997}. # SUBCELLULAR LOCATION BEPA_ECOLI Periplasm {ECO 0000255|HAMAP-Rule MF_00997, ECO 0000269|PubMed 22491786, ECO 0000269|PubMed 24003122}. Note=A significant amount of BepA is membrane-associated. This localization could result from interaction with the BAM complex. # SUBUNIT BEPA_ECOLI Interacts with BamA and LoiP. {ECO 0000269|PubMed 22491786, ECO 0000269|PubMed 24003122}. # SUPFAM SSF48452 SSF48452 # eggNOG COG4783 LUCA # eggNOG ENOG4105ERG Bacteria BLAST swissprot:BEPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BEPA_ECOLI BioCyc ECOL316407:JW2479-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2479-MONOMER BioCyc EcoCyc:G7311-MONOMER http://biocyc.org/getid?id=EcoCyc:G7311-MONOMER DIP DIP-28089N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-28089N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1039/c2mb05506f http://dx.doi.org/10.1039/c2mb05506f DOI 10.1073/pnas.1312012110 http://dx.doi.org/10.1073/pnas.1312012110 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.-.- {ECO:0000255|HAMAP-Rule:MF_00997} http://www.genome.jp/dbget-bin/www_bget?EC:3.4.-.- {ECO:0000255|HAMAP-Rule:MF_00997} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.4.-.- {ECO:0000255|HAMAP-Rule:MF_00997} http://enzyme.expasy.org/EC/3.4.-.- {ECO:0000255|HAMAP-Rule:MF_00997} EchoBASE EB3951 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3951 EcoGene EG14199 http://www.ecogene.org/geneInfo.php?eg_id=EG14199 EnsemblBacteria AAC75547 http://www.ensemblgenomes.org/id/AAC75547 EnsemblBacteria AAC75547 http://www.ensemblgenomes.org/id/AAC75547 EnsemblBacteria BAE76724 http://www.ensemblgenomes.org/id/BAE76724 EnsemblBacteria BAE76724 http://www.ensemblgenomes.org/id/BAE76724 EnsemblBacteria BAE76724 http://www.ensemblgenomes.org/id/BAE76724 EnsemblBacteria b2494 http://www.ensemblgenomes.org/id/b2494 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0004222 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004222 GO_function GO:0008237 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008237 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_process GO:0061077 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061077 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 Gene3D 1.25.40.10 http://www.cathdb.info/version/latest/superfamily/1.25.40.10 GeneID 947029 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947029 HAMAP MF_00997 http://hamap.expasy.org/unirule/MF_00997 HOGENOM HOG000264031 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000264031&db=HOGENOM6 InParanoid P66948 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P66948 IntAct P66948 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P66948* IntEnz 3.4.-.- {ECO:0000255|HAMAP-Rule:MF_00997} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.-.- {ECO:0000255|HAMAP-Rule:MF_00997} InterPro IPR001915 http://www.ebi.ac.uk/interpro/entry/IPR001915 InterPro IPR011990 http://www.ebi.ac.uk/interpro/entry/IPR011990 InterPro IPR030873 http://www.ebi.ac.uk/interpro/entry/IPR030873 KEGG_Gene ecj:JW2479 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2479 KEGG_Gene eco:b2494 http://www.genome.jp/dbget-bin/www_bget?eco:b2494 OMA DPQLKDY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DPQLKDY PSORT swissprot:BEPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BEPA_ECOLI PSORT-B swissprot:BEPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BEPA_ECOLI PSORT2 swissprot:BEPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BEPA_ECOLI Pfam PF01435 http://pfam.xfam.org/family/PF01435 Phobius swissprot:BEPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BEPA_ECOLI PhylomeDB P66948 http://phylomedb.org/?seqid=P66948 ProteinModelPortal P66948 http://www.proteinmodelportal.org/query/uniprot/P66948 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22491786 http://www.ncbi.nlm.nih.gov/pubmed/22491786 PubMed 24003122 http://www.ncbi.nlm.nih.gov/pubmed/24003122 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416989 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416989 RefSeq WP_000489667 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000489667 SMR P66948 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P66948 STRING 511145.b2494 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2494&targetmode=cogs SUPFAM SSF48452 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48452 UniProtKB BEPA_ECOLI http://www.uniprot.org/uniprot/BEPA_ECOLI UniProtKB-AC P66948 http://www.uniprot.org/uniprot/P66948 charge swissprot:BEPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BEPA_ECOLI eggNOG COG4783 http://eggnogapi.embl.de/nog_data/html/tree/COG4783 eggNOG ENOG4105ERG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ERG epestfind swissprot:BEPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BEPA_ECOLI garnier swissprot:BEPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BEPA_ECOLI helixturnhelix swissprot:BEPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BEPA_ECOLI hmoment swissprot:BEPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BEPA_ECOLI iep swissprot:BEPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BEPA_ECOLI inforesidue swissprot:BEPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BEPA_ECOLI octanol swissprot:BEPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BEPA_ECOLI pepcoil swissprot:BEPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BEPA_ECOLI pepdigest swissprot:BEPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BEPA_ECOLI pepinfo swissprot:BEPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BEPA_ECOLI pepnet swissprot:BEPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BEPA_ECOLI pepstats swissprot:BEPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BEPA_ECOLI pepwheel swissprot:BEPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BEPA_ECOLI pepwindow swissprot:BEPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BEPA_ECOLI sigcleave swissprot:BEPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BEPA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259229 14 # EcoGene EG13069 ygfS # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0016491 oxidoreductase activity; IBA:GO_Central. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # InterPro IPR017896 4Fe4S_Fe-S-bd # InterPro IPR017900 4Fe4S_Fe_S_CS # Organism YGFS_ECOLI Escherichia coli (strain K12) # PATRIC 32121180 VBIEscCol129921_2978 # PIR F65072 F65072 # PROSITE PS00198 4FE4S_FER_1 # PROSITE PS51379 4FE4S_FER_2; 4 # Pfam PF13247 Fer4_11 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGFS_ECOLI Putative electron transport protein YgfS # RefSeq NP_417362 NC_000913.3 # RefSeq WP_000838428 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA83067.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Contains 4 4Fe-4S ferredoxin-type domains. {ECO:0000255|PROSITE-ProRule PRU00711}. # eggNOG COG1142 LUCA # eggNOG ENOG4108R8B Bacteria BLAST swissprot:YGFS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGFS_ECOLI BioCyc ECOL316407:JW5468-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5468-MONOMER BioCyc EcoCyc:G7505-MONOMER http://biocyc.org/getid?id=EcoCyc:G7505-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 EchoBASE EB2880 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2880 EcoGene EG13069 http://www.ecogene.org/geneInfo.php?eg_id=EG13069 EnsemblBacteria AAC75924 http://www.ensemblgenomes.org/id/AAC75924 EnsemblBacteria AAC75924 http://www.ensemblgenomes.org/id/AAC75924 EnsemblBacteria BAE76951 http://www.ensemblgenomes.org/id/BAE76951 EnsemblBacteria BAE76951 http://www.ensemblgenomes.org/id/BAE76951 EnsemblBacteria BAE76951 http://www.ensemblgenomes.org/id/BAE76951 EnsemblBacteria b2886 http://www.ensemblgenomes.org/id/b2886 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GeneID 949016 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949016 HOGENOM HOG000163385 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000163385&db=HOGENOM6 InParanoid Q46819 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46819 InterPro IPR017896 http://www.ebi.ac.uk/interpro/entry/IPR017896 InterPro IPR017900 http://www.ebi.ac.uk/interpro/entry/IPR017900 KEGG_Gene ecj:JW5468 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5468 KEGG_Gene eco:b2886 http://www.genome.jp/dbget-bin/www_bget?eco:b2886 OMA SVPVMCH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SVPVMCH PROSITE PS00198 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00198 PROSITE PS51379 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51379 PSORT swissprot:YGFS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGFS_ECOLI PSORT-B swissprot:YGFS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGFS_ECOLI PSORT2 swissprot:YGFS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGFS_ECOLI Pfam PF13247 http://pfam.xfam.org/family/PF13247 Phobius swissprot:YGFS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGFS_ECOLI PhylomeDB Q46819 http://phylomedb.org/?seqid=Q46819 ProteinModelPortal Q46819 http://www.proteinmodelportal.org/query/uniprot/Q46819 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417362 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417362 RefSeq WP_000838428 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000838428 SMR Q46819 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46819 STRING 511145.b2886 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2886&targetmode=cogs UniProtKB YGFS_ECOLI http://www.uniprot.org/uniprot/YGFS_ECOLI UniProtKB-AC Q46819 http://www.uniprot.org/uniprot/Q46819 charge swissprot:YGFS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGFS_ECOLI eggNOG COG1142 http://eggnogapi.embl.de/nog_data/html/tree/COG1142 eggNOG ENOG4108R8B http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108R8B epestfind swissprot:YGFS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGFS_ECOLI garnier swissprot:YGFS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGFS_ECOLI helixturnhelix swissprot:YGFS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGFS_ECOLI hmoment swissprot:YGFS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGFS_ECOLI iep swissprot:YGFS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGFS_ECOLI inforesidue swissprot:YGFS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGFS_ECOLI octanol swissprot:YGFS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGFS_ECOLI pepcoil swissprot:YGFS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGFS_ECOLI pepdigest swissprot:YGFS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGFS_ECOLI pepinfo swissprot:YGFS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGFS_ECOLI pepnet swissprot:YGFS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGFS_ECOLI pepstats swissprot:YGFS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGFS_ECOLI pepwheel swissprot:YGFS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGFS_ECOLI pepwindow swissprot:YGFS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGFS_ECOLI sigcleave swissprot:YGFS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGFS_ECOLI ## Database ID URL or Descriptions # FUNCTION PSIB1_ECOLI In contrast to PsiB protein of plasmid R6-5, this protein is unable to prevent SOS induction for potentially two reasons less activity and/or insufficient expression. # InterPro IPR009385 Plasmid_inhPsiB # Organism PSIB1_ECOLI Escherichia coli (strain K12) # PDB 3NCT X-ray; 2.20 A; A/B/C/D=1-144 # PIR S01898 S01898 # Pfam PF06290 PsiB # RecName PSIB1_ECOLI Protein PsiB # RefSeq NP_061442 NC_002483.1 # RefSeq WP_010892539 NC_002483.1 # SIMILARITY To PsiB protein of plasmid R6-5. {ECO 0000305}. BLAST swissprot:PSIB1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PSIB1_ECOLI DOI 10.1006/plas.1999.1390 http://dx.doi.org/10.1006/plas.1999.1390 DOI 10.1093/nar/16.22.10669 http://dx.doi.org/10.1093/nar/16.22.10669 EMBL AF106329 http://www.ebi.ac.uk/ena/data/view/AF106329 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL X12462 http://www.ebi.ac.uk/ena/data/view/X12462 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1263521 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263521 InterPro IPR009385 http://www.ebi.ac.uk/interpro/entry/IPR009385 OMA ANWMING http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ANWMING PDB 3NCT http://www.ebi.ac.uk/pdbe-srv/view/entry/3NCT PDBsum 3NCT http://www.ebi.ac.uk/pdbsum/3NCT PSORT swissprot:PSIB1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PSIB1_ECOLI PSORT-B swissprot:PSIB1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PSIB1_ECOLI PSORT2 swissprot:PSIB1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PSIB1_ECOLI Pfam PF06290 http://pfam.xfam.org/family/PF06290 Phobius swissprot:PSIB1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PSIB1_ECOLI ProteinModelPortal P10031 http://www.proteinmodelportal.org/query/uniprot/P10031 PubMed 10366527 http://www.ncbi.nlm.nih.gov/pubmed/10366527 PubMed 3205720 http://www.ncbi.nlm.nih.gov/pubmed/3205720 RefSeq NP_061442 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061442 RefSeq WP_010892539 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_010892539 SMR P10031 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P10031 UniProtKB PSIB1_ECOLI http://www.uniprot.org/uniprot/PSIB1_ECOLI UniProtKB-AC P10031 http://www.uniprot.org/uniprot/P10031 charge swissprot:PSIB1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PSIB1_ECOLI epestfind swissprot:PSIB1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PSIB1_ECOLI garnier swissprot:PSIB1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PSIB1_ECOLI helixturnhelix swissprot:PSIB1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PSIB1_ECOLI hmoment swissprot:PSIB1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PSIB1_ECOLI iep swissprot:PSIB1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PSIB1_ECOLI inforesidue swissprot:PSIB1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PSIB1_ECOLI octanol swissprot:PSIB1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PSIB1_ECOLI pepcoil swissprot:PSIB1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PSIB1_ECOLI pepdigest swissprot:PSIB1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PSIB1_ECOLI pepinfo swissprot:PSIB1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PSIB1_ECOLI pepnet swissprot:PSIB1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PSIB1_ECOLI pepstats swissprot:PSIB1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PSIB1_ECOLI pepwheel swissprot:PSIB1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PSIB1_ECOLI pepwindow swissprot:PSIB1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PSIB1_ECOLI sigcleave swissprot:PSIB1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PSIB1_ECOLI ## Database ID URL or Descriptions # BioGrid 4260229 8 # EcoGene EG13813 yneE # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR021134 Bestrophin/UPF0187 # Organism YNEE_ECOLI Escherichia coli (strain K12) # PATRIC 32118336 VBIEscCol129921_1588 # PIR C64906 C64906 # Pfam PF01062 Bestrophin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNEE_ECOLI UPF0187 protein YneE # RefSeq NP_416037 NC_000913.3 # RefSeq WP_001313828 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0187 family. {ECO 0000305}. # SUBCELLULAR LOCATION YNEE_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # eggNOG COG3781 LUCA # eggNOG ENOG4105FFC Bacteria BLAST swissprot:YNEE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNEE_ECOLI BioCyc ECOL316407:JW5245-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5245-MONOMER BioCyc EcoCyc:G6807-MONOMER http://biocyc.org/getid?id=EcoCyc:G6807-MONOMER COG COG3781 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3781 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3574 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3574 EcoGene EG13813 http://www.ecogene.org/geneInfo.php?eg_id=EG13813 EnsemblBacteria AAC74593 http://www.ensemblgenomes.org/id/AAC74593 EnsemblBacteria AAC74593 http://www.ensemblgenomes.org/id/AAC74593 EnsemblBacteria BAE76460 http://www.ensemblgenomes.org/id/BAE76460 EnsemblBacteria BAE76460 http://www.ensemblgenomes.org/id/BAE76460 EnsemblBacteria BAE76460 http://www.ensemblgenomes.org/id/BAE76460 EnsemblBacteria b1520 http://www.ensemblgenomes.org/id/b1520 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 946188 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946188 HOGENOM HOG000200177 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000200177&db=HOGENOM6 InParanoid P76146 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76146 InterPro IPR021134 http://www.ebi.ac.uk/interpro/entry/IPR021134 KEGG_Gene ecj:JW5245 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5245 KEGG_Gene eco:b1520 http://www.genome.jp/dbget-bin/www_bget?eco:b1520 KEGG_Orthology KO:K08994 http://www.genome.jp/dbget-bin/www_bget?KO:K08994 OMA LCGFAHA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LCGFAHA PSORT swissprot:YNEE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNEE_ECOLI PSORT-B swissprot:YNEE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNEE_ECOLI PSORT2 swissprot:YNEE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNEE_ECOLI Pfam PF01062 http://pfam.xfam.org/family/PF01062 Phobius swissprot:YNEE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNEE_ECOLI PhylomeDB P76146 http://phylomedb.org/?seqid=P76146 ProteinModelPortal P76146 http://www.proteinmodelportal.org/query/uniprot/P76146 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416037 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416037 RefSeq WP_001313828 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001313828 SMR P76146 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76146 STRING 511145.b1520 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1520&targetmode=cogs STRING COG3781 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3781&targetmode=cogs UniProtKB YNEE_ECOLI http://www.uniprot.org/uniprot/YNEE_ECOLI UniProtKB-AC P76146 http://www.uniprot.org/uniprot/P76146 charge swissprot:YNEE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNEE_ECOLI eggNOG COG3781 http://eggnogapi.embl.de/nog_data/html/tree/COG3781 eggNOG ENOG4105FFC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FFC epestfind swissprot:YNEE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNEE_ECOLI garnier swissprot:YNEE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNEE_ECOLI helixturnhelix swissprot:YNEE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNEE_ECOLI hmoment swissprot:YNEE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNEE_ECOLI iep swissprot:YNEE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNEE_ECOLI inforesidue swissprot:YNEE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNEE_ECOLI octanol swissprot:YNEE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNEE_ECOLI pepcoil swissprot:YNEE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNEE_ECOLI pepdigest swissprot:YNEE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNEE_ECOLI pepinfo swissprot:YNEE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNEE_ECOLI pepnet swissprot:YNEE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNEE_ECOLI pepstats swissprot:YNEE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNEE_ECOLI pepwheel swissprot:YNEE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNEE_ECOLI pepwindow swissprot:YNEE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNEE_ECOLI sigcleave swissprot:YNEE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNEE_ECOLI ## Database ID URL or Descriptions # BioGrid 4262556 14 # CATALYTIC ACTIVITY ADH2_ECOLI An alcohol + NAD(+) = an aldehyde or ketone + NADH. # COFACTOR Name=Fe cation; Xref=ChEBI:CHEBI 24875; Evidence={ECO:0000250}; # EcoGene EG12293 yiaY # GO_function GO:0004022 alcohol dehydrogenase (NAD) activity; IMP:CACAO. # GO_function GO:0008743 L-threonine 3-dehydrogenase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:InterPro. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # InterPro IPR001670 ADH_Fe # InterPro IPR018211 ADH_Fe_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00010 Glycolysis / Gluconeogenesis # KEGG_Pathway ko00071 Fatty acid metabolism # KEGG_Pathway ko00350 Tyrosine metabolism # KEGG_Pathway ko00625 Chloroalkane and chloroalkene degradation # KEGG_Pathway ko00626 Naphthalene degradation # Organism ADH2_ECOLI Escherichia coli (strain K12) # PATRIC 32122656 VBIEscCol129921_3705 # PIR S47810 S47810 # PROSITE PS00060 ADH_IRON_2 # PROSITE PS00913 ADH_IRON_1 # Pfam PF00465 Fe-ADH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ADH2_ECOLI Probable alcohol dehydrogenase # RefSeq WP_000741518 NZ_LN832404.1 # RefSeq YP_026233 NC_000913.3 # SIMILARITY Belongs to the iron-containing alcohol dehydrogenase family. {ECO 0000305}. # eggNOG COG1454 LUCA # eggNOG ENOG4105C0A Bacteria BLAST swissprot:ADH2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ADH2_ECOLI BioCyc ECOL316407:JW5648-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5648-MONOMER BioCyc EcoCyc:EG12293-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12293-MONOMER BioCyc MetaCyc:EG12293-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12293-MONOMER COG COG1454 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1454 DIP DIP-12414N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12414N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.1 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L40742 http://www.ebi.ac.uk/ena/data/view/L40742 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.1.1.1 http://enzyme.expasy.org/EC/1.1.1.1 EchoBASE EB2201 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2201 EcoGene EG12293 http://www.ecogene.org/geneInfo.php?eg_id=EG12293 EnsemblBacteria AAT48195 http://www.ensemblgenomes.org/id/AAT48195 EnsemblBacteria AAT48195 http://www.ensemblgenomes.org/id/AAT48195 EnsemblBacteria BAE77704 http://www.ensemblgenomes.org/id/BAE77704 EnsemblBacteria BAE77704 http://www.ensemblgenomes.org/id/BAE77704 EnsemblBacteria BAE77704 http://www.ensemblgenomes.org/id/BAE77704 EnsemblBacteria b3589 http://www.ensemblgenomes.org/id/b3589 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004022 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004022 GO_function GO:0008743 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008743 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GeneID 948102 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948102 HOGENOM HOG000243333 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000243333&db=HOGENOM6 InParanoid P37686 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37686 IntEnz 1.1.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.1 InterPro IPR001670 http://www.ebi.ac.uk/interpro/entry/IPR001670 InterPro IPR018211 http://www.ebi.ac.uk/interpro/entry/IPR018211 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5648 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5648 KEGG_Gene eco:b3589 http://www.genome.jp/dbget-bin/www_bget?eco:b3589 KEGG_Orthology KO:K13954 http://www.genome.jp/dbget-bin/www_bget?KO:K13954 KEGG_Pathway ko00010 http://www.genome.jp/kegg-bin/show_pathway?ko00010 KEGG_Pathway ko00071 http://www.genome.jp/kegg-bin/show_pathway?ko00071 KEGG_Pathway ko00350 http://www.genome.jp/kegg-bin/show_pathway?ko00350 KEGG_Pathway ko00625 http://www.genome.jp/kegg-bin/show_pathway?ko00625 KEGG_Pathway ko00626 http://www.genome.jp/kegg-bin/show_pathway?ko00626 KEGG_Reaction rn:R00623 http://www.genome.jp/dbget-bin/www_bget?rn:R00623 KEGG_Reaction rn:R00754 http://www.genome.jp/dbget-bin/www_bget?rn:R00754 KEGG_Reaction rn:R04880 http://www.genome.jp/dbget-bin/www_bget?rn:R04880 KEGG_Reaction rn:R05233 http://www.genome.jp/dbget-bin/www_bget?rn:R05233 KEGG_Reaction rn:R05234 http://www.genome.jp/dbget-bin/www_bget?rn:R05234 KEGG_Reaction rn:R06917 http://www.genome.jp/dbget-bin/www_bget?rn:R06917 KEGG_Reaction rn:R06927 http://www.genome.jp/dbget-bin/www_bget?rn:R06927 OMA IPTVNLM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IPTVNLM PROSITE PS00060 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00060 PROSITE PS00913 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00913 PSORT swissprot:ADH2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ADH2_ECOLI PSORT-B swissprot:ADH2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ADH2_ECOLI PSORT2 swissprot:ADH2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ADH2_ECOLI Pfam PF00465 http://pfam.xfam.org/family/PF00465 Phobius swissprot:ADH2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ADH2_ECOLI PhylomeDB P37686 http://phylomedb.org/?seqid=P37686 ProteinModelPortal P37686 http://www.proteinmodelportal.org/query/uniprot/P37686 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7768815 http://www.ncbi.nlm.nih.gov/pubmed/7768815 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000741518 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000741518 RefSeq YP_026233 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026233 SMR P37686 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37686 STRING 511145.b3589 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3589&targetmode=cogs STRING COG1454 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1454&targetmode=cogs UniProtKB ADH2_ECOLI http://www.uniprot.org/uniprot/ADH2_ECOLI UniProtKB-AC P37686 http://www.uniprot.org/uniprot/P37686 charge swissprot:ADH2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ADH2_ECOLI eggNOG COG1454 http://eggnogapi.embl.de/nog_data/html/tree/COG1454 eggNOG ENOG4105C0A http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C0A epestfind swissprot:ADH2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ADH2_ECOLI garnier swissprot:ADH2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ADH2_ECOLI helixturnhelix swissprot:ADH2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ADH2_ECOLI hmoment swissprot:ADH2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ADH2_ECOLI iep swissprot:ADH2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ADH2_ECOLI inforesidue swissprot:ADH2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ADH2_ECOLI octanol swissprot:ADH2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ADH2_ECOLI pepcoil swissprot:ADH2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ADH2_ECOLI pepdigest swissprot:ADH2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ADH2_ECOLI pepinfo swissprot:ADH2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ADH2_ECOLI pepnet swissprot:ADH2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ADH2_ECOLI pepstats swissprot:ADH2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ADH2_ECOLI pepwheel swissprot:ADH2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ADH2_ECOLI pepwindow swissprot:ADH2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ADH2_ECOLI sigcleave swissprot:ADH2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ADH2_ECOLI ## Database ID URL or Descriptions # AltName DLGD_ECOLI 3-dehydro-L-gulonate 2-dehydrogenase # BioGrid 4262546 12 # CATALYTIC ACTIVITY DLGD_ECOLI 3-dehydro-L-gulonate + NAD(P)(+) = (4R,5S)- 4,5,6-trihydroxy-2,3-dioxohexanoate + NAD(P)H. # ENZYME REGULATION DLGD_ECOLI The enzyme is inhibited by tartrate and D- malate. # EcoGene EG12279 dlgD # FUNCTION DLGD_ECOLI Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate. {ECO 0000269|PubMed 11741871}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IDA:EcoCyc. # GO_function GO:0047559 3-dehydro-L-gulonate 2-dehydrogenase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0070403 NAD+ binding; IEA:InterPro. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # HAMAP MF_00820 Diketo_gul_reduc # InterPro IPR003767 Malate/L-lactate_DH # InterPro IPR023689 Diketo_gul_Rdtase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00040 Pentose and glucuronate interconversions # KEGG_Pathway ko00053 Ascorbate and aldarate metabolism # MISCELLANEOUS DLGD_ECOLI NAD is bound in an unusual conformation, at the interface of a dimer of the enzyme. # Organism DLGD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11091 PTHR11091 # PATRIC 32122626 VBIEscCol129921_3690 # PDB 1NXU X-ray; 1.80 A; A/B=1-332 # PDB 1S20 X-ray; 2.20 A; A/B/C/D/E/F/G/H=1-332 # PIR A65157 A65157 # Pfam PF02615 Ldh_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DLGD_ECOLI 2,3-diketo-L-gulonate reductase # RefSeq NP_418032 NC_000913.3 # RefSeq WP_000869037 NZ_LN832404.1 # SIMILARITY Belongs to the LDH2/MDH2 oxidoreductase family. DlgD subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION DLGD_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 14718529}. # SUPFAM SSF89733 SSF89733 # eggNOG COG2055 LUCA # eggNOG ENOG4105DG4 Bacteria BLAST swissprot:DLGD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DLGD_ECOLI BioCyc ECOL316407:JW3547-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3547-MONOMER BioCyc EcoCyc:EG12279-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12279-MONOMER BioCyc MetaCyc:EG12279-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12279-MONOMER COG COG2055 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2055 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.273.14.8376 http://dx.doi.org/10.1074/jbc.273.14.8376 DOI 10.1074/jbc.M313580200 http://dx.doi.org/10.1074/jbc.M313580200 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.1.302-306.2002 http://dx.doi.org/10.1128/JB.184.1.302-306.2002 EC_number EC:1.1.1.130 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.130 EMBL AJ223475 http://www.ebi.ac.uk/ena/data/view/AJ223475 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.1.1.130 http://enzyme.expasy.org/EC/1.1.1.130 EchoBASE EB2187 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2187 EcoGene EG12279 http://www.ecogene.org/geneInfo.php?eg_id=EG12279 EnsemblBacteria AAC76599 http://www.ensemblgenomes.org/id/AAC76599 EnsemblBacteria AAC76599 http://www.ensemblgenomes.org/id/AAC76599 EnsemblBacteria BAE77718 http://www.ensemblgenomes.org/id/BAE77718 EnsemblBacteria BAE77718 http://www.ensemblgenomes.org/id/BAE77718 EnsemblBacteria BAE77718 http://www.ensemblgenomes.org/id/BAE77718 EnsemblBacteria b3575 http://www.ensemblgenomes.org/id/b3575 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0016616 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016616 GO_function GO:0047559 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047559 GO_function GO:0070403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070403 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GeneID 948096 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948096 HAMAP MF_00820 http://hamap.expasy.org/unirule/MF_00820 HOGENOM HOG000249660 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000249660&db=HOGENOM6 IntEnz 1.1.1.130 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.130 InterPro IPR003767 http://www.ebi.ac.uk/interpro/entry/IPR003767 InterPro IPR023689 http://www.ebi.ac.uk/interpro/entry/IPR023689 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3547 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3547 KEGG_Gene eco:b3575 http://www.genome.jp/dbget-bin/www_bget?eco:b3575 KEGG_Orthology KO:K08092 http://www.genome.jp/dbget-bin/www_bget?KO:K08092 KEGG_Pathway ko00040 http://www.genome.jp/kegg-bin/show_pathway?ko00040 KEGG_Pathway ko00053 http://www.genome.jp/kegg-bin/show_pathway?ko00053 KEGG_Reaction rn:R02637 http://www.genome.jp/dbget-bin/www_bget?rn:R02637 KEGG_Reaction rn:R02639 http://www.genome.jp/dbget-bin/www_bget?rn:R02639 OMA AIKNTNH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AIKNTNH PANTHER PTHR11091 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11091 PDB 1NXU http://www.ebi.ac.uk/pdbe-srv/view/entry/1NXU PDB 1S20 http://www.ebi.ac.uk/pdbe-srv/view/entry/1S20 PDBsum 1NXU http://www.ebi.ac.uk/pdbsum/1NXU PDBsum 1S20 http://www.ebi.ac.uk/pdbsum/1S20 PSORT swissprot:DLGD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DLGD_ECOLI PSORT-B swissprot:DLGD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DLGD_ECOLI PSORT2 swissprot:DLGD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DLGD_ECOLI Pfam PF02615 http://pfam.xfam.org/family/PF02615 Phobius swissprot:DLGD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DLGD_ECOLI PhylomeDB P37672 http://phylomedb.org/?seqid=P37672 ProteinModelPortal P37672 http://www.proteinmodelportal.org/query/uniprot/P37672 PubMed 11741871 http://www.ncbi.nlm.nih.gov/pubmed/11741871 PubMed 14718529 http://www.ncbi.nlm.nih.gov/pubmed/14718529 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9525947 http://www.ncbi.nlm.nih.gov/pubmed/9525947 RefSeq NP_418032 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418032 RefSeq WP_000869037 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000869037 SMR P37672 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37672 STRING 511145.b3575 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3575&targetmode=cogs STRING COG2055 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2055&targetmode=cogs SUPFAM SSF89733 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF89733 UniProtKB DLGD_ECOLI http://www.uniprot.org/uniprot/DLGD_ECOLI UniProtKB-AC P37672 http://www.uniprot.org/uniprot/P37672 charge swissprot:DLGD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DLGD_ECOLI eggNOG COG2055 http://eggnogapi.embl.de/nog_data/html/tree/COG2055 eggNOG ENOG4105DG4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DG4 epestfind swissprot:DLGD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DLGD_ECOLI garnier swissprot:DLGD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DLGD_ECOLI helixturnhelix swissprot:DLGD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DLGD_ECOLI hmoment swissprot:DLGD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DLGD_ECOLI iep swissprot:DLGD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DLGD_ECOLI inforesidue swissprot:DLGD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DLGD_ECOLI octanol swissprot:DLGD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DLGD_ECOLI pepcoil swissprot:DLGD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DLGD_ECOLI pepdigest swissprot:DLGD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DLGD_ECOLI pepinfo swissprot:DLGD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DLGD_ECOLI pepnet swissprot:DLGD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DLGD_ECOLI pepstats swissprot:DLGD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DLGD_ECOLI pepwheel swissprot:DLGD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DLGD_ECOLI pepwindow swissprot:DLGD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DLGD_ECOLI sigcleave swissprot:DLGD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DLGD_ECOLI ## Database ID URL or Descriptions # BioGrid 4260325 7 # CATALYTIC ACTIVITY YEAJ_ECOLI 2 GTP = 2 diphosphate + cyclic di-3',5'- guanylate. # CDD cd01949 GGDEF # COFACTOR YEAJ_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250}; Note=Binds 1 Mg(2+) ion per monomer. {ECO 0000250}; # DISRUPTION PHENOTYPE No visible phenotype. Disruption of this gene partially suppresses the reduced motility of a yhjH disruption. Full suppression i.e. wild-type motility, requires concomitant disruption of yeaJ, yegE and yedQ. {ECO:0000269|PubMed 18765794}. # EcoGene EG13496 yeaJ # FUNCTION YEAJ_ECOLI Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0052621 diguanylate cyclase activity; IEA:UniProtKB-EC. # GO_process GO:1902201 negative regulation of bacterial-type flagellum-dependent cell motility; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # INDUCTION Expressed during exponential and post-exponential growth, it is slightly more highly expressed at 37 than 28 degrees Celsius and is more highly induced on solid medium. {ECO:0000269|PubMed 19332833}. # INTERACTION YEAJ_ECOLI P32715 mdtO; NbExp=2; IntAct=EBI-555763, EBI-555775; # IntAct P76237 2 # InterPro IPR000160 GGDEF_dom # InterPro IPR029787 Nucleotide_cyclase # InterPro IPR033420 GAPES1 # Organism YEAJ_ECOLI Escherichia coli (strain K12) # PATHWAY YEAJ_ECOLI Purine metabolism; 3',5'-cyclic di-GMP biosynthesis. # PATRIC 32118883 VBIEscCol129921_1859 # PIR B64939 B64939 # PROSITE PS50887 GGDEF # Pfam PF00990 GGDEF # Pfam PF17155 GAPES1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEAJ_ECOLI Putative diguanylate cyclase YeaJ # RefSeq NP_416300 NC_000913.3 # RefSeq WP_000766132 NZ_LN832404.1 # SIMILARITY Contains 1 GGDEF domain. {ECO:0000255|PROSITE- ProRule PRU00095}. # SMART SM00267 GGDEF # SUBCELLULAR LOCATION YEAJ_ECOLI Cell inner membrane {ECO 0000305}; Multi- pass membrane protein {ECO 0000305}. # SUBUNIT Homodimer. {ECO 0000250}. # SUPFAM SSF55073 SSF55073 # TIGRFAMs TIGR00254 GGDEF # eggNOG COG2199 LUCA # eggNOG ENOG4108KHP Bacteria BLAST swissprot:YEAJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEAJ_ECOLI BioCyc ECOL316407:JW5291-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5291-MONOMER BioCyc EcoCyc:G6972-MONOMER http://biocyc.org/getid?id=EcoCyc:G6972-MONOMER DIP DIP-11789N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11789N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1099/mic.0.024257-0 http://dx.doi.org/10.1099/mic.0.024257-0 DOI 10.1101/gad.475808 http://dx.doi.org/10.1101/gad.475808 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.7.65 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.65 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.7.65 http://enzyme.expasy.org/EC/2.7.7.65 EchoBASE EB3269 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3269 EcoGene EG13496 http://www.ecogene.org/geneInfo.php?eg_id=EG13496 EnsemblBacteria AAC74856 http://www.ensemblgenomes.org/id/AAC74856 EnsemblBacteria AAC74856 http://www.ensemblgenomes.org/id/AAC74856 EnsemblBacteria BAA15587 http://www.ensemblgenomes.org/id/BAA15587 EnsemblBacteria BAA15587 http://www.ensemblgenomes.org/id/BAA15587 EnsemblBacteria BAA15587 http://www.ensemblgenomes.org/id/BAA15587 EnsemblBacteria b1786 http://www.ensemblgenomes.org/id/b1786 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0052621 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052621 GO_process GO:1902201 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902201 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 946290 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946290 HOGENOM HOG000121142 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000121142&db=HOGENOM6 InParanoid P76237 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76237 IntAct P76237 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76237* IntEnz 2.7.7.65 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.65 InterPro IPR000160 http://www.ebi.ac.uk/interpro/entry/IPR000160 InterPro IPR029787 http://www.ebi.ac.uk/interpro/entry/IPR029787 InterPro IPR033420 http://www.ebi.ac.uk/interpro/entry/IPR033420 KEGG_Gene ecj:JW5291 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5291 KEGG_Gene eco:b1786 http://www.genome.jp/dbget-bin/www_bget?eco:b1786 MINT MINT-1239476 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1239476 OMA SINRAQD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SINRAQD PROSITE PS50887 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50887 PSORT swissprot:YEAJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEAJ_ECOLI PSORT-B swissprot:YEAJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEAJ_ECOLI PSORT2 swissprot:YEAJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEAJ_ECOLI Pfam PF00990 http://pfam.xfam.org/family/PF00990 Pfam PF17155 http://pfam.xfam.org/family/PF17155 Phobius swissprot:YEAJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEAJ_ECOLI PhylomeDB P76237 http://phylomedb.org/?seqid=P76237 ProteinModelPortal P76237 http://www.proteinmodelportal.org/query/uniprot/P76237 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18765794 http://www.ncbi.nlm.nih.gov/pubmed/18765794 PubMed 19332833 http://www.ncbi.nlm.nih.gov/pubmed/19332833 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416300 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416300 RefSeq WP_000766132 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000766132 SMART SM00267 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00267 SMR P76237 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76237 STRING 511145.b1786 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1786&targetmode=cogs SUPFAM SSF55073 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55073 TIGRFAMs TIGR00254 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00254 UniProtKB YEAJ_ECOLI http://www.uniprot.org/uniprot/YEAJ_ECOLI UniProtKB-AC P76237 http://www.uniprot.org/uniprot/P76237 charge swissprot:YEAJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEAJ_ECOLI eggNOG COG2199 http://eggnogapi.embl.de/nog_data/html/tree/COG2199 eggNOG ENOG4108KHP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108KHP epestfind swissprot:YEAJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEAJ_ECOLI garnier swissprot:YEAJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEAJ_ECOLI helixturnhelix swissprot:YEAJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEAJ_ECOLI hmoment swissprot:YEAJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEAJ_ECOLI iep swissprot:YEAJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEAJ_ECOLI inforesidue swissprot:YEAJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEAJ_ECOLI octanol swissprot:YEAJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEAJ_ECOLI pepcoil swissprot:YEAJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEAJ_ECOLI pepdigest swissprot:YEAJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEAJ_ECOLI pepinfo swissprot:YEAJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEAJ_ECOLI pepnet swissprot:YEAJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEAJ_ECOLI pepstats swissprot:YEAJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEAJ_ECOLI pepwheel swissprot:YEAJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEAJ_ECOLI pepwindow swissprot:YEAJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEAJ_ECOLI sigcleave swissprot:YEAJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEAJ_ECOLI ## Database ID URL or Descriptions # BRENDA 2.4.2.52 2026 # BioGrid 4259903 8 # CATALYTIC ACTIVITY CITG_ECOLI ATP + 3'-dephospho-CoA = 2'-(5-triphospho- alpha-D-ribosyl)-3'-dephospho-CoA + adenine. # EcoGene EG13539 citG # FUNCTION CITG_ECOLI Catalyzes the formation of 2-(5''-triphosphoribosyl)-3'- dephosphocoenzyme-A, the precursor of the prosthetic group of the holo-acyl carrier protein (gamma chain) of citrate lyase, from ATP and dephospho-CoA. {ECO 0000269|PubMed 10924139, ECO 0000269|PubMed 11042274}. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0046917 triphosphoribosyl-dephospho-CoA synthase activity; IDA:EcoCyc. # GO_process GO:0016310 phosphorylation; IEA:InterPro. # GO_process GO:0051191 prosthetic group biosynthetic process; IDA:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0051186 cofactor metabolic process # HAMAP MF_00397 CitG # INDUCTION Repressed by H-NS. Part of the citCDEFXG operon. {ECO:0000269|PubMed 19429622}. # IntAct P77231 2 # InterPro IPR002736 CitG # InterPro IPR017551 TriPribosyl-deP-CoA_syn_CitG # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko02020 Two-component system # Organism CITG_ECOLI Escherichia coli (strain K12) # PATRIC 32116406 VBIEscCol129921_0643 # PIR C64795 C64795 # Pfam PF01874 CitG # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CITG_ECOLI 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase # RefSeq NP_415146 NC_000913.3 # RefSeq WP_000062457 NZ_LN832404.1 # SIMILARITY Belongs to the CitG/MdcB family. {ECO 0000305}. # TIGRFAMs TIGR03125 citrate_citG # eggNOG COG1767 LUCA # eggNOG ENOG4108K6F Bacteria BLAST swissprot:CITG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CITG_ECOLI BioCyc ECOL316407:JW0605-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0605-MONOMER BioCyc EcoCyc:G6339-MONOMER http://biocyc.org/getid?id=EcoCyc:G6339-MONOMER BioCyc MetaCyc:G6339-MONOMER http://biocyc.org/getid?id=MetaCyc:G6339-MONOMER COG COG1767 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1767 DOI 10.1016/S0014-5793(00)02105-0 http://dx.doi.org/10.1016/S0014-5793(00)02105-0 DOI 10.1021/bi000401r http://dx.doi.org/10.1021/bi000401r DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00108-09 http://dx.doi.org/10.1128/JB.00108-09 EC_number EC:2.4.2.52 http://www.genome.jp/dbget-bin/www_bget?EC:2.4.2.52 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 ENZYME 2.4.2.52 http://enzyme.expasy.org/EC/2.4.2.52 EchoBASE EB3309 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3309 EcoGene EG13539 http://www.ecogene.org/geneInfo.php?eg_id=EG13539 EnsemblBacteria AAC73714 http://www.ensemblgenomes.org/id/AAC73714 EnsemblBacteria AAC73714 http://www.ensemblgenomes.org/id/AAC73714 EnsemblBacteria BAE76353 http://www.ensemblgenomes.org/id/BAE76353 EnsemblBacteria BAE76353 http://www.ensemblgenomes.org/id/BAE76353 EnsemblBacteria BAE76353 http://www.ensemblgenomes.org/id/BAE76353 EnsemblBacteria b0613 http://www.ensemblgenomes.org/id/b0613 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0046917 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046917 GO_process GO:0016310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016310 GO_process GO:0051191 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051191 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GeneID 946395 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946395 HAMAP MF_00397 http://hamap.expasy.org/unirule/MF_00397 HOGENOM HOG000258582 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000258582&db=HOGENOM6 InParanoid P77231 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77231 IntAct P77231 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77231* IntEnz 2.4.2.52 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.2.52 InterPro IPR002736 http://www.ebi.ac.uk/interpro/entry/IPR002736 InterPro IPR017551 http://www.ebi.ac.uk/interpro/entry/IPR017551 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0605 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0605 KEGG_Gene eco:b0613 http://www.genome.jp/dbget-bin/www_bget?eco:b0613 KEGG_Orthology KO:K05966 http://www.genome.jp/dbget-bin/www_bget?KO:K05966 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA IHRGGIK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IHRGGIK PSORT swissprot:CITG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CITG_ECOLI PSORT-B swissprot:CITG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CITG_ECOLI PSORT2 swissprot:CITG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CITG_ECOLI Pfam PF01874 http://pfam.xfam.org/family/PF01874 Phobius swissprot:CITG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CITG_ECOLI PhylomeDB P77231 http://phylomedb.org/?seqid=P77231 ProteinModelPortal P77231 http://www.proteinmodelportal.org/query/uniprot/P77231 PubMed 10924139 http://www.ncbi.nlm.nih.gov/pubmed/10924139 PubMed 11042274 http://www.ncbi.nlm.nih.gov/pubmed/11042274 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19429622 http://www.ncbi.nlm.nih.gov/pubmed/19429622 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415146 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415146 RefSeq WP_000062457 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000062457 STRING 511145.b0613 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0613&targetmode=cogs STRING COG1767 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1767&targetmode=cogs TIGRFAMs TIGR03125 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03125 UniProtKB CITG_ECOLI http://www.uniprot.org/uniprot/CITG_ECOLI UniProtKB-AC P77231 http://www.uniprot.org/uniprot/P77231 charge swissprot:CITG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CITG_ECOLI eggNOG COG1767 http://eggnogapi.embl.de/nog_data/html/tree/COG1767 eggNOG ENOG4108K6F http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108K6F epestfind swissprot:CITG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CITG_ECOLI garnier swissprot:CITG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CITG_ECOLI helixturnhelix swissprot:CITG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CITG_ECOLI hmoment swissprot:CITG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CITG_ECOLI iep swissprot:CITG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CITG_ECOLI inforesidue swissprot:CITG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CITG_ECOLI octanol swissprot:CITG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CITG_ECOLI pepcoil swissprot:CITG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CITG_ECOLI pepdigest swissprot:CITG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CITG_ECOLI pepinfo swissprot:CITG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CITG_ECOLI pepnet swissprot:CITG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CITG_ECOLI pepstats swissprot:CITG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CITG_ECOLI pepwheel swissprot:CITG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CITG_ECOLI pepwindow swissprot:CITG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CITG_ECOLI sigcleave swissprot:CITG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CITG_ECOLI ## Database ID URL or Descriptions # AltName COPB1_ECOLI Protein CopB # FUNCTION COPB1_ECOLI This protein is involved in the determination of copy number in gene replication. It binds to the repA promoter thus inhibiting the synthesis of the mRNA for the initiator protein RepA. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006276 plasmid maintenance; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # InterPro IPR019661 RepA2 # Organism COPB1_ECOLI Escherichia coli (strain K12) # PIR A26870 QQECAP # Pfam PF10723 RepB-RCR_reg # RecName COPB1_ECOLI Replication regulatory protein RepA2 # RefSeq NP_061385 NC_002483.1 # RefSeq WP_000083834 NZ_CP014273.1 BLAST swissprot:COPB1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:COPB1_ECOLI EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL M16167 http://www.ebi.ac.uk/ena/data/view/M16167 EMBL M16168 http://www.ebi.ac.uk/ena/data/view/M16168 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006276 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 1263536 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263536 InterPro IPR019661 http://www.ebi.ac.uk/interpro/entry/IPR019661 OMA QLQEMCE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QLQEMCE PSORT swissprot:COPB1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:COPB1_ECOLI PSORT-B swissprot:COPB1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:COPB1_ECOLI PSORT2 swissprot:COPB1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:COPB1_ECOLI Pfam PF10723 http://pfam.xfam.org/family/PF10723 Phobius swissprot:COPB1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:COPB1_ECOLI ProteinModelPortal P13959 http://www.proteinmodelportal.org/query/uniprot/P13959 PubMed 3032897 http://www.ncbi.nlm.nih.gov/pubmed/3032897 RefSeq NP_061385 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061385 RefSeq WP_000083834 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000083834 UniProtKB COPB1_ECOLI http://www.uniprot.org/uniprot/COPB1_ECOLI UniProtKB-AC P13959 http://www.uniprot.org/uniprot/P13959 charge swissprot:COPB1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:COPB1_ECOLI epestfind swissprot:COPB1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:COPB1_ECOLI garnier swissprot:COPB1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:COPB1_ECOLI helixturnhelix swissprot:COPB1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:COPB1_ECOLI hmoment swissprot:COPB1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:COPB1_ECOLI iep swissprot:COPB1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:COPB1_ECOLI inforesidue swissprot:COPB1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:COPB1_ECOLI octanol swissprot:COPB1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:COPB1_ECOLI pepcoil swissprot:COPB1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:COPB1_ECOLI pepdigest swissprot:COPB1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:COPB1_ECOLI pepinfo swissprot:COPB1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:COPB1_ECOLI pepnet swissprot:COPB1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:COPB1_ECOLI pepstats swissprot:COPB1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:COPB1_ECOLI pepwheel swissprot:COPB1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:COPB1_ECOLI pepwindow swissprot:COPB1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:COPB1_ECOLI sigcleave swissprot:COPB1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:COPB1_ECOLI ## Database ID URL or Descriptions # AltName SYT_ECOLI Threonyl-tRNA synthetase # BRENDA 6.1.1 2026 # BioGrid 4262193 16 # CATALYTIC ACTIVITY SYT_ECOLI ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr). # CDD cd00771 ThrRS_core # COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI 29105; Note=Binds 1 zinc ion per subunit.; # DOMAIN SYT_ECOLI The C-terminal domain recognizes the anticodon bases but the N-terminal contributes also to the precise recognition of tRNA(Thr) by ThrRS. # EcoGene EG11001 thrS # FUNCTION SYT_ECOLI ThrS is also a translational repressor protein, it controls the translation of its own gene by binding to its mRNA. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000900 translation repressor activity, nucleic acid binding; IDA:EcoCyc. # GO_function GO:0003723 RNA binding; IDA:EcoliWiki. # GO_function GO:0004829 threonine-tRNA ligase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IDA:EcoliWiki. # GO_function GO:0008144 drug binding; IDA:EcoliWiki. # GO_function GO:0008270 zinc ion binding; IMP:EcoliWiki. # GO_function GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds; IDA:EcoliWiki. # GO_process GO:0006418 tRNA aminoacylation for protein translation; IDA:EcoliWiki. # GO_process GO:0006435 threonyl-tRNA aminoacylation; IDA:EcoCyc. # GO_process GO:0043039 tRNA aminoacylation; IDA:EcoliWiki. # GO_process GO:0045947 negative regulation of translational initiation; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0008150 biological_process # Gene3D 3.10.20.30 -; 1. # Gene3D 3.40.50.800 -; 1. # HAMAP MF_00184 Thr_tRNA_synth # INTERACTION SYT_ECOLI P0A7L0 rplA; NbExp=2; IntAct=EBI-551254, EBI-543771; # IntAct P0A8M3 49 # InterPro IPR002314 aa-tRNA-synt_IIb # InterPro IPR002320 Thr-tRNA-ligase_IIa # InterPro IPR004095 TGS # InterPro IPR004154 Anticodon-bd # InterPro IPR006195 aa-tRNA-synth_II # InterPro IPR012675 Beta-grasp_dom # InterPro IPR012676 TGS-like # InterPro IPR012947 tRNA_SAD # InterPro IPR018163 Thr/Ala-tRNA-synth_IIc_edit # InterPro IPR033728 ThrRS_core # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01007 Amino acid related enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # KEGG_Pathway ko00970 Aminoacyl-tRNA biosynthesis # Organism SYT_ECOLI Escherichia coli (strain K12) # PATRIC 32118742 VBIEscCol129921_1789 # PDB 1EVK X-ray; 2.00 A; A/B=242-642 # PDB 1EVL X-ray; 1.55 A; A/B/C/D=242-642 # PDB 1FYF X-ray; 1.65 A; A/B=242-642 # PDB 1KOG X-ray; 3.50 A; A/B/C/D/E/F/G/H=242-642 # PDB 1QF6 X-ray; 2.90 A; A=1-642 # PDB 1TJE X-ray; 1.50 A; A=1-224 # PDB 1TKE X-ray; 1.46 A; A=1-224 # PDB 1TKG X-ray; 1.50 A; A=1-224 # PDB 1TKY X-ray; 1.48 A; A=1-224 # PDB 4HWO X-ray; 1.91 A; A/B=242-642 # PDB 4HWP X-ray; 1.81 A; A/B=242-642 # PDB 4HWR X-ray; 1.90 A; A/B=242-642 # PDB 4HWS X-ray; 1.70 A; A/B=242-642 # PDB 4P3O X-ray; 2.50 A; A/B=242-642 # PDB 4P3P X-ray; 2.10 A; A/B=242-642 # PIR G64930 SYECTT # PRINTS PR01047 TRNASYNTHTHR # PROSITE PS50862 AA_TRNA_LIGASE_II # Pfam PF00587 tRNA-synt_2b # Pfam PF02824 TGS # Pfam PF03129 HGTP_anticodon # Pfam PF07973 tRNA_SAD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SYT_ECOLI Threonine--tRNA ligase # RefSeq NP_416234 NC_000913.3 # RefSeq WP_001144202 NZ_LN832404.1 # SIMILARITY Belongs to the class-II aminoacyl-tRNA synthetase family. {ECO 0000305}. # SMART SM00863 tRNA_SAD # SUBCELLULAR LOCATION SYT_ECOLI Cytoplasm. # SUBUNIT SYT_ECOLI Homodimer. # SUPFAM SSF52954 SSF52954 # SUPFAM SSF55186 SSF55186 # SUPFAM SSF81271 SSF81271 # TIGRFAMs TIGR00418 thrS # eggNOG COG0441 LUCA # eggNOG ENOG4105C22 Bacteria BLAST swissprot:SYT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SYT_ECOLI BioCyc ECOL316407:JW1709-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1709-MONOMER BioCyc EcoCyc:THRS-MONOMER http://biocyc.org/getid?id=EcoCyc:THRS-MONOMER BioCyc MetaCyc:THRS-MONOMER http://biocyc.org/getid?id=MetaCyc:THRS-MONOMER COG COG0441 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0441 DIP DIP-35823N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35823N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/S0092-8674(00)80746-1 http://dx.doi.org/10.1016/S0092-8674(00)80746-1 DOI 10.1038/75856 http://dx.doi.org/10.1038/75856 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.80.20.6152 http://dx.doi.org/10.1073/pnas.80.20.6152 DOI 10.1073/pnas.83.12.4384 http://dx.doi.org/10.1073/pnas.83.12.4384 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.1.1.3 http://www.genome.jp/dbget-bin/www_bget?EC:6.1.1.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M13549 http://www.ebi.ac.uk/ena/data/view/M13549 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00291 http://www.ebi.ac.uk/ena/data/view/V00291 ENZYME 6.1.1.3 http://enzyme.expasy.org/EC/6.1.1.3 EchoBASE EB0994 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0994 EcoGene EG11001 http://www.ecogene.org/geneInfo.php?eg_id=EG11001 EnsemblBacteria AAC74789 http://www.ensemblgenomes.org/id/AAC74789 EnsemblBacteria AAC74789 http://www.ensemblgenomes.org/id/AAC74789 EnsemblBacteria BAA15498 http://www.ensemblgenomes.org/id/BAA15498 EnsemblBacteria BAA15498 http://www.ensemblgenomes.org/id/BAA15498 EnsemblBacteria BAA15498 http://www.ensemblgenomes.org/id/BAA15498 EnsemblBacteria b1719 http://www.ensemblgenomes.org/id/b1719 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000900 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000900 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0004829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004829 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008144 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008144 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0016876 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016876 GO_process GO:0006418 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006418 GO_process GO:0006435 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006435 GO_process GO:0043039 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043039 GO_process GO:0045947 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045947 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.10.20.30 http://www.cathdb.info/version/latest/superfamily/3.10.20.30 Gene3D 3.40.50.800 http://www.cathdb.info/version/latest/superfamily/3.40.50.800 GeneID 946222 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946222 HAMAP MF_00184 http://hamap.expasy.org/unirule/MF_00184 HOGENOM HOG000003880 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000003880&db=HOGENOM6 InParanoid P0A8M3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8M3 IntAct P0A8M3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8M3* IntEnz 6.1.1.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.1.1.3 InterPro IPR002314 http://www.ebi.ac.uk/interpro/entry/IPR002314 InterPro IPR002320 http://www.ebi.ac.uk/interpro/entry/IPR002320 InterPro IPR004095 http://www.ebi.ac.uk/interpro/entry/IPR004095 InterPro IPR004154 http://www.ebi.ac.uk/interpro/entry/IPR004154 InterPro IPR006195 http://www.ebi.ac.uk/interpro/entry/IPR006195 InterPro IPR012675 http://www.ebi.ac.uk/interpro/entry/IPR012675 InterPro IPR012676 http://www.ebi.ac.uk/interpro/entry/IPR012676 InterPro IPR012947 http://www.ebi.ac.uk/interpro/entry/IPR012947 InterPro IPR018163 http://www.ebi.ac.uk/interpro/entry/IPR018163 InterPro IPR033728 http://www.ebi.ac.uk/interpro/entry/IPR033728 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW1709 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1709 KEGG_Gene eco:b1719 http://www.genome.jp/dbget-bin/www_bget?eco:b1719 KEGG_Orthology KO:K01868 http://www.genome.jp/dbget-bin/www_bget?KO:K01868 KEGG_Pathway ko00970 http://www.genome.jp/kegg-bin/show_pathway?ko00970 KEGG_Reaction rn:R03663 http://www.genome.jp/dbget-bin/www_bget?rn:R03663 MINT MINT-1229097 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1229097 OMA FYYDFAY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FYYDFAY PDB 1EVK http://www.ebi.ac.uk/pdbe-srv/view/entry/1EVK PDB 1EVL http://www.ebi.ac.uk/pdbe-srv/view/entry/1EVL PDB 1FYF http://www.ebi.ac.uk/pdbe-srv/view/entry/1FYF PDB 1KOG http://www.ebi.ac.uk/pdbe-srv/view/entry/1KOG PDB 1QF6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1QF6 PDB 1TJE http://www.ebi.ac.uk/pdbe-srv/view/entry/1TJE PDB 1TKE http://www.ebi.ac.uk/pdbe-srv/view/entry/1TKE PDB 1TKG http://www.ebi.ac.uk/pdbe-srv/view/entry/1TKG PDB 1TKY http://www.ebi.ac.uk/pdbe-srv/view/entry/1TKY PDB 4HWO http://www.ebi.ac.uk/pdbe-srv/view/entry/4HWO PDB 4HWP http://www.ebi.ac.uk/pdbe-srv/view/entry/4HWP PDB 4HWR http://www.ebi.ac.uk/pdbe-srv/view/entry/4HWR PDB 4HWS http://www.ebi.ac.uk/pdbe-srv/view/entry/4HWS PDB 4P3O http://www.ebi.ac.uk/pdbe-srv/view/entry/4P3O PDB 4P3P http://www.ebi.ac.uk/pdbe-srv/view/entry/4P3P PDBsum 1EVK http://www.ebi.ac.uk/pdbsum/1EVK PDBsum 1EVL http://www.ebi.ac.uk/pdbsum/1EVL PDBsum 1FYF http://www.ebi.ac.uk/pdbsum/1FYF PDBsum 1KOG http://www.ebi.ac.uk/pdbsum/1KOG PDBsum 1QF6 http://www.ebi.ac.uk/pdbsum/1QF6 PDBsum 1TJE http://www.ebi.ac.uk/pdbsum/1TJE PDBsum 1TKE http://www.ebi.ac.uk/pdbsum/1TKE PDBsum 1TKG http://www.ebi.ac.uk/pdbsum/1TKG PDBsum 1TKY http://www.ebi.ac.uk/pdbsum/1TKY PDBsum 4HWO http://www.ebi.ac.uk/pdbsum/4HWO PDBsum 4HWP http://www.ebi.ac.uk/pdbsum/4HWP PDBsum 4HWR http://www.ebi.ac.uk/pdbsum/4HWR PDBsum 4HWS http://www.ebi.ac.uk/pdbsum/4HWS PDBsum 4P3O http://www.ebi.ac.uk/pdbsum/4P3O PDBsum 4P3P http://www.ebi.ac.uk/pdbsum/4P3P PRINTS PR01047 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01047 PROSITE PS50862 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50862 PSORT swissprot:SYT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SYT_ECOLI PSORT-B swissprot:SYT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SYT_ECOLI PSORT2 swissprot:SYT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SYT_ECOLI Pfam PF00587 http://pfam.xfam.org/family/PF00587 Pfam PF02824 http://pfam.xfam.org/family/PF02824 Pfam PF03129 http://pfam.xfam.org/family/PF03129 Pfam PF07973 http://pfam.xfam.org/family/PF07973 Phobius swissprot:SYT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SYT_ECOLI PhylomeDB P0A8M3 http://phylomedb.org/?seqid=P0A8M3 ProteinModelPortal P0A8M3 http://www.proteinmodelportal.org/query/uniprot/P0A8M3 PubMed 10319817 http://www.ncbi.nlm.nih.gov/pubmed/10319817 PubMed 10881191 http://www.ncbi.nlm.nih.gov/pubmed/10881191 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 3086882 http://www.ncbi.nlm.nih.gov/pubmed/3086882 PubMed 6353409 http://www.ncbi.nlm.nih.gov/pubmed/6353409 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_416234 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416234 RefSeq WP_001144202 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001144202 SMART SM00863 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00863 SMR P0A8M3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8M3 STRING 511145.b1719 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1719&targetmode=cogs STRING COG0441 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0441&targetmode=cogs SUPFAM SSF52954 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52954 SUPFAM SSF55186 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55186 SUPFAM SSF81271 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81271 TIGRFAMs TIGR00418 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00418 UniProtKB SYT_ECOLI http://www.uniprot.org/uniprot/SYT_ECOLI UniProtKB-AC P0A8M3 http://www.uniprot.org/uniprot/P0A8M3 charge swissprot:SYT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SYT_ECOLI eggNOG COG0441 http://eggnogapi.embl.de/nog_data/html/tree/COG0441 eggNOG ENOG4105C22 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C22 epestfind swissprot:SYT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SYT_ECOLI garnier swissprot:SYT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SYT_ECOLI helixturnhelix swissprot:SYT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SYT_ECOLI hmoment swissprot:SYT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SYT_ECOLI iep swissprot:SYT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SYT_ECOLI inforesidue swissprot:SYT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SYT_ECOLI octanol swissprot:SYT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SYT_ECOLI pepcoil swissprot:SYT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SYT_ECOLI pepdigest swissprot:SYT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SYT_ECOLI pepinfo swissprot:SYT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SYT_ECOLI pepnet swissprot:SYT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SYT_ECOLI pepstats swissprot:SYT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SYT_ECOLI pepwheel swissprot:SYT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SYT_ECOLI pepwindow swissprot:SYT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SYT_ECOLI sigcleave swissprot:SYT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SYT_ECOLI ## Database ID URL or Descriptions # BioGrid 4260329 14 # EcoGene EG14304 yoaF # InterPro IPR005590 DUF333 # Organism YOAF_ECOLI Escherichia coli (strain K12) # PATRIC 32118899 VBIEscCol129921_1867 # PIR A64940 A64940 # Pfam PF03891 DUF333 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YOAF_ECOLI Uncharacterized protein YoaF # RefSeq NP_416307 NC_000913.3 # RefSeq WP_000691930 NZ_LN832404.1 # eggNOG COG3042 LUCA # eggNOG ENOG4105UCG Bacteria BLAST swissprot:YOAF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YOAF_ECOLI BioCyc ECOL316407:JW1782-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1782-MONOMER BioCyc EcoCyc:G6979-MONOMER http://biocyc.org/getid?id=EcoCyc:G6979-MONOMER COG COG3042 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3042 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4051 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4051 EcoGene EG14304 http://www.ecogene.org/geneInfo.php?eg_id=EG14304 EnsemblBacteria AAC74863 http://www.ensemblgenomes.org/id/AAC74863 EnsemblBacteria AAC74863 http://www.ensemblgenomes.org/id/AAC74863 EnsemblBacteria BAE76530 http://www.ensemblgenomes.org/id/BAE76530 EnsemblBacteria BAE76530 http://www.ensemblgenomes.org/id/BAE76530 EnsemblBacteria BAE76530 http://www.ensemblgenomes.org/id/BAE76530 EnsemblBacteria b1793 http://www.ensemblgenomes.org/id/b1793 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946310 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946310 HOGENOM HOG000262732 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000262732&db=HOGENOM6 InParanoid P64493 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P64493 InterPro IPR005590 http://www.ebi.ac.uk/interpro/entry/IPR005590 KEGG_Gene ecj:JW1782 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1782 KEGG_Gene eco:b1793 http://www.genome.jp/dbget-bin/www_bget?eco:b1793 KEGG_Orthology KO:K09712 http://www.genome.jp/dbget-bin/www_bget?KO:K09712 OMA KIDEWAL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KIDEWAL PSORT swissprot:YOAF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YOAF_ECOLI PSORT-B swissprot:YOAF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YOAF_ECOLI PSORT2 swissprot:YOAF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YOAF_ECOLI Pfam PF03891 http://pfam.xfam.org/family/PF03891 Phobius swissprot:YOAF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YOAF_ECOLI ProteinModelPortal P64493 http://www.proteinmodelportal.org/query/uniprot/P64493 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416307 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416307 RefSeq WP_000691930 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000691930 STRING 511145.b1793 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1793&targetmode=cogs STRING COG3042 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3042&targetmode=cogs UniProtKB YOAF_ECOLI http://www.uniprot.org/uniprot/YOAF_ECOLI UniProtKB-AC P64493 http://www.uniprot.org/uniprot/P64493 charge swissprot:YOAF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YOAF_ECOLI eggNOG COG3042 http://eggnogapi.embl.de/nog_data/html/tree/COG3042 eggNOG ENOG4105UCG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105UCG epestfind swissprot:YOAF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YOAF_ECOLI garnier swissprot:YOAF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YOAF_ECOLI helixturnhelix swissprot:YOAF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YOAF_ECOLI hmoment swissprot:YOAF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YOAF_ECOLI iep swissprot:YOAF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YOAF_ECOLI inforesidue swissprot:YOAF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YOAF_ECOLI octanol swissprot:YOAF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YOAF_ECOLI pepcoil swissprot:YOAF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YOAF_ECOLI pepdigest swissprot:YOAF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YOAF_ECOLI pepinfo swissprot:YOAF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YOAF_ECOLI pepnet swissprot:YOAF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YOAF_ECOLI pepstats swissprot:YOAF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YOAF_ECOLI pepwheel swissprot:YOAF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YOAF_ECOLI pepwindow swissprot:YOAF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YOAF_ECOLI sigcleave swissprot:YOAF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YOAF_ECOLI ## Database ID URL or Descriptions # BioGrid 4262509 11 # COFACTOR Name=Ni(2+); Xref=ChEBI:CHEBI 49786; Note=Binds 1 nickel ion per subunit.; # EcoGene EG11519 nikR # FUNCTION NIKR_ECOLI Transcriptional repressor of the nikABCDE operon. Is active in the presence of excessive concentrations of intracellular nickel. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0016151 nickel cation binding; TAS:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IMP:EcoCyc. # GO_process GO:0010045 response to nickel cation; IEA:InterPro. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.1220.10 -; 1. # HAMAP MF_00476 NikR # INTERACTION NIKR_ECOLI P77650 hcaD; NbExp=2; IntAct=EBI-562488, EBI-1129389; # IntAct P0A6Z6 15 # InterPro IPR002145 CopG # InterPro IPR010985 Ribbon_hlx_hlx # InterPro IPR013321 Arc_rbn_hlx_hlx # InterPro IPR014160 Nickel_NikR_proteobac # InterPro IPR014864 TF_NikR_Ni-bd_C # InterPro IPR022988 Ni_resp_reg_NikR # KEGG_Brite ko03000 Transcription factors # Organism NIKR_ECOLI Escherichia coli (strain K12) # PATRIC 32122406 VBIEscCol129921_3580 # PDB 1Q5V X-ray; 2.30 A; A/B/C/D=1-133 # PDB 1Q5Y X-ray; 1.40 A; A/B/C/D=49-133 # PDB 2HZA X-ray; 2.10 A; A/B=1-133 # PDB 2HZV X-ray; 3.10 A; A/B/C/D/E/F/G/H=1-133 # PDB 3BKF X-ray; 1.90 A; A=48-133 # PDB 3BKT X-ray; 1.50 A; A/B/C/D=48-133 # PDB 3BKU X-ray; 2.10 A; A/B/C/D=48-133 # PDB 3OD2 X-ray; 2.60 A; A/B=1-133 # PIR S47700 S47700 # Pfam PF01402 RHH_1 # Pfam PF08753 NikR_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NIKR_ECOLI Nickel-responsive regulator # RefSeq NP_417938 NC_000913.3 # RefSeq WP_001190062 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA04676.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the transcriptional regulatory CopG/NikR family. {ECO 0000305}. # SUBUNIT NIKR_ECOLI Homotetramer. # SUPFAM SSF47598 SSF47598 # TIGRFAMs TIGR02793 nikR # eggNOG COG0864 LUCA # eggNOG ENOG4105MRR Bacteria BLAST swissprot:NIKR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NIKR_ECOLI BioCyc ECOL316407:JW3446-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3446-MONOMER BioCyc EcoCyc:EG11519-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11519-MONOMER COG COG0864 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0864 DIP DIP-48066N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48066N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb985 http://dx.doi.org/10.1038/nsb985 DOI 10.1074/jbc.M002232200 http://dx.doi.org/10.1074/jbc.M002232200 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1110/ps.8.11.2494 http://dx.doi.org/10.1110/ps.8.11.2494 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1271/bbb.58.117 http://dx.doi.org/10.1271/bbb.58.117 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D21140 http://www.ebi.ac.uk/ena/data/view/D21140 EMBL L02370 http://www.ebi.ac.uk/ena/data/view/L02370 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL Y08952 http://www.ebi.ac.uk/ena/data/view/Y08952 EchoBASE EB1481 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1481 EcoGene EG11519 http://www.ecogene.org/geneInfo.php?eg_id=EG11519 EnsemblBacteria AAC76506 http://www.ensemblgenomes.org/id/AAC76506 EnsemblBacteria AAC76506 http://www.ensemblgenomes.org/id/AAC76506 EnsemblBacteria BAE77812 http://www.ensemblgenomes.org/id/BAE77812 EnsemblBacteria BAE77812 http://www.ensemblgenomes.org/id/BAE77812 EnsemblBacteria BAE77812 http://www.ensemblgenomes.org/id/BAE77812 EnsemblBacteria b3481 http://www.ensemblgenomes.org/id/b3481 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0016151 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016151 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0010045 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010045 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.1220.10 http://www.cathdb.info/version/latest/superfamily/1.10.1220.10 GeneID 947995 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947995 HAMAP MF_00476 http://hamap.expasy.org/unirule/MF_00476 HOGENOM HOG000102781 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000102781&db=HOGENOM6 InParanoid P0A6Z6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6Z6 IntAct P0A6Z6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6Z6* InterPro IPR002145 http://www.ebi.ac.uk/interpro/entry/IPR002145 InterPro IPR010985 http://www.ebi.ac.uk/interpro/entry/IPR010985 InterPro IPR013321 http://www.ebi.ac.uk/interpro/entry/IPR013321 InterPro IPR014160 http://www.ebi.ac.uk/interpro/entry/IPR014160 InterPro IPR014864 http://www.ebi.ac.uk/interpro/entry/IPR014864 InterPro IPR022988 http://www.ebi.ac.uk/interpro/entry/IPR022988 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW3446 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3446 KEGG_Gene eco:b3481 http://www.genome.jp/dbget-bin/www_bget?eco:b3481 KEGG_Orthology KO:K07722 http://www.genome.jp/dbget-bin/www_bget?KO:K07722 OMA ITIVYNH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ITIVYNH PDB 1Q5V http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q5V PDB 1Q5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q5Y PDB 2HZA http://www.ebi.ac.uk/pdbe-srv/view/entry/2HZA PDB 2HZV http://www.ebi.ac.uk/pdbe-srv/view/entry/2HZV PDB 3BKF http://www.ebi.ac.uk/pdbe-srv/view/entry/3BKF PDB 3BKT http://www.ebi.ac.uk/pdbe-srv/view/entry/3BKT PDB 3BKU http://www.ebi.ac.uk/pdbe-srv/view/entry/3BKU PDB 3OD2 http://www.ebi.ac.uk/pdbe-srv/view/entry/3OD2 PDBsum 1Q5V http://www.ebi.ac.uk/pdbsum/1Q5V PDBsum 1Q5Y http://www.ebi.ac.uk/pdbsum/1Q5Y PDBsum 2HZA http://www.ebi.ac.uk/pdbsum/2HZA PDBsum 2HZV http://www.ebi.ac.uk/pdbsum/2HZV PDBsum 3BKF http://www.ebi.ac.uk/pdbsum/3BKF PDBsum 3BKT http://www.ebi.ac.uk/pdbsum/3BKT PDBsum 3BKU http://www.ebi.ac.uk/pdbsum/3BKU PDBsum 3OD2 http://www.ebi.ac.uk/pdbsum/3OD2 PSORT swissprot:NIKR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NIKR_ECOLI PSORT-B swissprot:NIKR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NIKR_ECOLI PSORT2 swissprot:NIKR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NIKR_ECOLI Pfam PF01402 http://pfam.xfam.org/family/PF01402 Pfam PF08753 http://pfam.xfam.org/family/PF08753 Phobius swissprot:NIKR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NIKR_ECOLI PhylomeDB P0A6Z6 http://phylomedb.org/?seqid=P0A6Z6 ProteinModelPortal P0A6Z6 http://www.proteinmodelportal.org/query/uniprot/P0A6Z6 PubMed 10595554 http://www.ncbi.nlm.nih.gov/pubmed/10595554 PubMed 10787413 http://www.ncbi.nlm.nih.gov/pubmed/10787413 PubMed 12970756 http://www.ncbi.nlm.nih.gov/pubmed/12970756 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7764507 http://www.ncbi.nlm.nih.gov/pubmed/7764507 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 8387990 http://www.ncbi.nlm.nih.gov/pubmed/8387990 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9882686 http://www.ncbi.nlm.nih.gov/pubmed/9882686 RefSeq NP_417938 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417938 RefSeq WP_001190062 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001190062 SMR P0A6Z6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6Z6 STRING 511145.b3481 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3481&targetmode=cogs STRING COG0864 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0864&targetmode=cogs SUPFAM SSF47598 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47598 TIGRFAMs TIGR02793 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02793 UniProtKB NIKR_ECOLI http://www.uniprot.org/uniprot/NIKR_ECOLI UniProtKB-AC P0A6Z6 http://www.uniprot.org/uniprot/P0A6Z6 charge swissprot:NIKR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NIKR_ECOLI eggNOG COG0864 http://eggnogapi.embl.de/nog_data/html/tree/COG0864 eggNOG ENOG4105MRR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105MRR epestfind swissprot:NIKR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NIKR_ECOLI garnier swissprot:NIKR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NIKR_ECOLI helixturnhelix swissprot:NIKR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NIKR_ECOLI hmoment swissprot:NIKR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NIKR_ECOLI iep swissprot:NIKR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NIKR_ECOLI inforesidue swissprot:NIKR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NIKR_ECOLI octanol swissprot:NIKR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NIKR_ECOLI pepcoil swissprot:NIKR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NIKR_ECOLI pepdigest swissprot:NIKR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NIKR_ECOLI pepinfo swissprot:NIKR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NIKR_ECOLI pepnet swissprot:NIKR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NIKR_ECOLI pepstats swissprot:NIKR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NIKR_ECOLI pepwheel swissprot:NIKR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NIKR_ECOLI pepwindow swissprot:NIKR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NIKR_ECOLI sigcleave swissprot:NIKR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NIKR_ECOLI ## Database ID URL or Descriptions # AltName CBRB_ECOLI CreB-regulated gene B protein # BioGrid 4263199 6 # EcoGene EG11726 cbrB # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # INDUCTION Induced by the two-component regulatory system CreC/CreB. {ECO:0000269|PubMed 11350954}. # InterPro IPR020222 IMCbrB # MISCELLANEOUS CBRB_ECOLI Disruption of this gene leads to hypersensibility to nitrofurazone. # Organism CBRB_ECOLI Escherichia coli (strain K12) # PATRIC 32122927 VBIEscCol129921_3839 # PIR E65174 E65174 # ProDom PD092472 IM_protein_CbrB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CBRB_ECOLI Inner membrane protein CbrB # RefSeq NP_418172 NC_000913.3 # RefSeq WP_000116777 NZ_CP014272.1 # SIMILARITY Belongs to the CbrB family. {ECO 0000305}. # SUBCELLULAR LOCATION CBRB_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG ENOG4106HGK Bacteria # eggNOG ENOG410Y18Y LUCA BLAST swissprot:CBRB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CBRB_ECOLI BioCyc ECOL316407:JW3694-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3694-MONOMER BioCyc EcoCyc:EG11726-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11726-MONOMER DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M011186200 http://dx.doi.org/10.1074/jbc.M011186200 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.185.16.4956-4972.2003 http://dx.doi.org/10.1128/JB.185.16.4956-4972.2003 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1677 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1677 EcoGene EG11726 http://www.ecogene.org/geneInfo.php?eg_id=EG11726 EnsemblBacteria AAC76739 http://www.ensemblgenomes.org/id/AAC76739 EnsemblBacteria AAC76739 http://www.ensemblgenomes.org/id/AAC76739 EnsemblBacteria BAE77572 http://www.ensemblgenomes.org/id/BAE77572 EnsemblBacteria BAE77572 http://www.ensemblgenomes.org/id/BAE77572 EnsemblBacteria BAE77572 http://www.ensemblgenomes.org/id/BAE77572 EnsemblBacteria b3716 http://www.ensemblgenomes.org/id/b3716 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 948231 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948231 HOGENOM HOG000050898 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000050898&db=HOGENOM6 InterPro IPR020222 http://www.ebi.ac.uk/interpro/entry/IPR020222 KEGG_Gene ecj:JW3694 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3694 KEGG_Gene eco:b3716 http://www.genome.jp/dbget-bin/www_bget?eco:b3716 OMA IPTENAQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IPTENAQ PSORT swissprot:CBRB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CBRB_ECOLI PSORT-B swissprot:CBRB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CBRB_ECOLI PSORT2 swissprot:CBRB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CBRB_ECOLI Phobius swissprot:CBRB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CBRB_ECOLI ProteinModelPortal P31468 http://www.proteinmodelportal.org/query/uniprot/P31468 PubMed 11350954 http://www.ncbi.nlm.nih.gov/pubmed/11350954 PubMed 12897016 http://www.ncbi.nlm.nih.gov/pubmed/12897016 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418172 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418172 RefSeq WP_000116777 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000116777 STRING 511145.b3716 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3716&targetmode=cogs UniProtKB CBRB_ECOLI http://www.uniprot.org/uniprot/CBRB_ECOLI UniProtKB-AC P31468 http://www.uniprot.org/uniprot/P31468 charge swissprot:CBRB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CBRB_ECOLI eggNOG ENOG4106HGK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106HGK eggNOG ENOG410Y18Y http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y18Y epestfind swissprot:CBRB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CBRB_ECOLI garnier swissprot:CBRB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CBRB_ECOLI helixturnhelix swissprot:CBRB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CBRB_ECOLI hmoment swissprot:CBRB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CBRB_ECOLI iep swissprot:CBRB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CBRB_ECOLI inforesidue swissprot:CBRB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CBRB_ECOLI octanol swissprot:CBRB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CBRB_ECOLI pepcoil swissprot:CBRB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CBRB_ECOLI pepdigest swissprot:CBRB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CBRB_ECOLI pepinfo swissprot:CBRB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CBRB_ECOLI pepnet swissprot:CBRB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CBRB_ECOLI pepstats swissprot:CBRB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CBRB_ECOLI pepwheel swissprot:CBRB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CBRB_ECOLI pepwindow swissprot:CBRB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CBRB_ECOLI sigcleave swissprot:CBRB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CBRB_ECOLI ## Database ID URL or Descriptions # BioGrid 4259869 178 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG14285 ylbG # GO_function GO:0003677 DNA binding; IEA:InterPro. # GOslim_function GO:0003677 DNA binding # InterPro IPR009057 Homeodomain-like # Organism YLBG_ECOLI Escherichia coli (strain K12) # PATRIC 48660211 VBIEscCol107702_0499 # PIR C90699 C90699 # PIR E64781 E64781 # PIR F85549 F85549 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YLBG_ECOLI Putative uncharacterized protein YlbG # RefSeq WP_000903287 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40255.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SUPFAM SSF46689 SSF46689 BLAST swissprot:YLBG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YLBG_ECOLI BioCyc ECOL316407:JW5880-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5880-MONOMER BioCyc EcoCyc:G6273-MONOMER http://biocyc.org/getid?id=EcoCyc:G6273-MONOMER DIP DIP-48217N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48217N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EcoGene EG14285 http://www.ecogene.org/geneInfo.php?eg_id=EG14285 EnsemblBacteria BAE76280 http://www.ensemblgenomes.org/id/BAE76280 EnsemblBacteria BAE76280 http://www.ensemblgenomes.org/id/BAE76280 EnsemblBacteria BAE76280 http://www.ensemblgenomes.org/id/BAE76280 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 HOGENOM HOG000041887 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000041887&db=HOGENOM6 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 KEGG_Gene ecj:JW5880 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5880 OMA SIFISYR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SIFISYR PSORT swissprot:YLBG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YLBG_ECOLI PSORT-B swissprot:YLBG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YLBG_ECOLI PSORT2 swissprot:YLBG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YLBG_ECOLI Phobius swissprot:YLBG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YLBG_ECOLI ProteinModelPortal P77688 http://www.proteinmodelportal.org/query/uniprot/P77688 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000903287 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000903287 SMR P77688 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77688 STRING 316407.85674640 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85674640&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 UniProtKB YLBG_ECOLI http://www.uniprot.org/uniprot/YLBG_ECOLI UniProtKB-AC P77688 http://www.uniprot.org/uniprot/P77688 charge swissprot:YLBG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YLBG_ECOLI epestfind swissprot:YLBG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YLBG_ECOLI garnier swissprot:YLBG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YLBG_ECOLI helixturnhelix swissprot:YLBG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YLBG_ECOLI hmoment swissprot:YLBG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YLBG_ECOLI iep swissprot:YLBG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YLBG_ECOLI inforesidue swissprot:YLBG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YLBG_ECOLI octanol swissprot:YLBG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YLBG_ECOLI pepcoil swissprot:YLBG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YLBG_ECOLI pepdigest swissprot:YLBG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YLBG_ECOLI pepinfo swissprot:YLBG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YLBG_ECOLI pepnet swissprot:YLBG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YLBG_ECOLI pepstats swissprot:YLBG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YLBG_ECOLI pepwheel swissprot:YLBG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YLBG_ECOLI pepwindow swissprot:YLBG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YLBG_ECOLI sigcleave swissprot:YLBG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YLBG_ECOLI ## Database ID URL or Descriptions # BRENDA 2.10.1 2026 # BioGrid 4259979 8 # CATALYTIC ACTIVITY MOEA_ECOLI Adenylyl-molybdopterin + molybdate = molybdenum cofactor + AMP. # COFACTOR MOEA_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 11428898}; Note=Binds 1 Mg(2+) ion per subunit. {ECO 0000269|PubMed 11428898}; # EcoGene EG10153 moeA # FUNCTION MOEA_ECOLI Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. {ECO 0000269|PubMed 15632135}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0061598 molybdopterin adenylyltransferase activity; IBA:GO_Central. # GO_function GO:0061599 molybdopterin molybdotransferase activity; IDA:EcoCyc. # GO_process GO:0006777 Mo-molybdopterin cofactor biosynthetic process; IDA:EcoCyc. # GO_process GO:0018315 molybdenum incorporation into molybdenum-molybdopterin complex; IDA:EcoCyc. # GO_process GO:0032324 molybdopterin cofactor biosynthetic process; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 2.40.340.10 -; 1. # Gene3D 3.40.980.10 -; 1. # INTERACTION MOEA_ECOLI P32173 mobA; NbExp=3; IntAct=EBI-554393, EBI-1133881; # IntAct P12281 8 # InterPro IPR001453 MoaB/Mog_dom # InterPro IPR005110 MoeA_linker/N # InterPro IPR005111 MoeA_C_domain_IV # InterPro IPR008284 MoCF_biosynth_CS # KEGG_Brite ko01000 Enzymes # Organism MOEA_ECOLI Escherichia coli (strain K12) # PATHWAY MOEA_ECOLI Cofactor biosynthesis; molybdopterin biosynthesis. # PATRIC 32116857 VBIEscCol129921_0854 # PDB 1FC5 X-ray; 2.20 A; A/B=1-411 # PDB 1G8L X-ray; 1.95 A; A/B=1-411 # PDB 1G8R X-ray; 2.65 A; A/B=1-411 # PDB 2NQK X-ray; 2.90 A; A/B=1-411 # PDB 2NQM X-ray; 3.00 A; A/B=1-411 # PDB 2NQN X-ray; 2.20 A; A/B=1-411 # PDB 2NQQ X-ray; 2.40 A; A/B/C/D=1-411 # PDB 2NQR X-ray; 2.20 A; A/B=1-411 # PDB 2NQS X-ray; 2.50 A; A/B=1-411 # PDB 2NQU X-ray; 2.70 A; A/B=1-411 # PDB 2NQV X-ray; 2.82 A; A/B=1-411 # PDB 2NRO X-ray; 2.50 A; A/B=1-411 # PDB 2NRP X-ray; 3.00 A; A/B=1-411 # PDB 2NRS X-ray; 2.80 A; A/B=1-411 # PIR A32352 A32352 # PROSITE PS01079 MOCF_BIOSYNTHESIS_2 # Pfam PF00994 MoCF_biosynth # Pfam PF03453 MoeA_N # Pfam PF03454 MoeA_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MOEA_ECOLI Molybdopterin molybdenumtransferase # RefSeq NP_415348 NC_000913.3 # RefSeq WP_000397340 NZ_LN832404.1 # SIMILARITY Belongs to the MoeA family. {ECO 0000305}. # SMART SM00852 MoCF_biosynth # SUBUNIT MOEA_ECOLI Homodimer. Interacts with MobA, MogA and MobB in vivo. {ECO 0000269|PubMed 11428898, ECO 0000269|PubMed 11525167, ECO 0000269|PubMed 12372836}. # SUPFAM SSF53218 SSF53218 # SUPFAM SSF63867 SSF63867 # SUPFAM SSF63882 SSF63882 # TIGRFAMs TIGR00177 molyb_syn # eggNOG COG0303 LUCA # eggNOG ENOG4105CVM Bacteria BLAST swissprot:MOEA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MOEA_ECOLI BioCyc ECOL316407:JW0811-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0811-MONOMER BioCyc EcoCyc:EG10153-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10153-MONOMER BioCyc MetaCyc:EG10153-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10153-MONOMER COG COG0303 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0303 DIP DIP-10240N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10240N DOI 10.1006/jmbi.2001.4771 http://dx.doi.org/10.1006/jmbi.2001.4771 DOI 10.1016/S0969-2126(01)00588-3 http://dx.doi.org/10.1016/S0969-2126(01)00588-3 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M205806200 http://dx.doi.org/10.1074/jbc.M205806200 DOI 10.1074/jbc.M413783200 http://dx.doi.org/10.1074/jbc.M413783200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.10.1.1 http://www.genome.jp/dbget-bin/www_bget?EC:2.10.1.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M21151 http://www.ebi.ac.uk/ena/data/view/M21151 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.10.1.1 http://enzyme.expasy.org/EC/2.10.1.1 EchoBASE EB0151 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0151 EcoGene EG10153 http://www.ecogene.org/geneInfo.php?eg_id=EG10153 EnsemblBacteria AAC73914 http://www.ensemblgenomes.org/id/AAC73914 EnsemblBacteria AAC73914 http://www.ensemblgenomes.org/id/AAC73914 EnsemblBacteria BAA35515 http://www.ensemblgenomes.org/id/BAA35515 EnsemblBacteria BAA35515 http://www.ensemblgenomes.org/id/BAA35515 EnsemblBacteria BAA35515 http://www.ensemblgenomes.org/id/BAA35515 EnsemblBacteria b0827 http://www.ensemblgenomes.org/id/b0827 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0061598 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061598 GO_function GO:0061599 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061599 GO_process GO:0006777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006777 GO_process GO:0018315 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018315 GO_process GO:0032324 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032324 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 2.40.340.10 http://www.cathdb.info/version/latest/superfamily/2.40.340.10 Gene3D 3.40.980.10 http://www.cathdb.info/version/latest/superfamily/3.40.980.10 GeneID 945454 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945454 HOGENOM HOG000280652 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000280652&db=HOGENOM6 InParanoid P12281 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P12281 IntAct P12281 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P12281* IntEnz 2.10.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.10.1.1 InterPro IPR001453 http://www.ebi.ac.uk/interpro/entry/IPR001453 InterPro IPR005110 http://www.ebi.ac.uk/interpro/entry/IPR005110 InterPro IPR005111 http://www.ebi.ac.uk/interpro/entry/IPR005111 InterPro IPR008284 http://www.ebi.ac.uk/interpro/entry/IPR008284 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0811 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0811 KEGG_Gene eco:b0827 http://www.genome.jp/dbget-bin/www_bget?eco:b0827 KEGG_Orthology KO:K03750 http://www.genome.jp/dbget-bin/www_bget?KO:K03750 KEGG_Reaction rn:R09735 http://www.genome.jp/dbget-bin/www_bget?rn:R09735 MINT MINT-1250871 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1250871 OMA FALAPKD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FALAPKD PDB 1FC5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1FC5 PDB 1G8L http://www.ebi.ac.uk/pdbe-srv/view/entry/1G8L PDB 1G8R http://www.ebi.ac.uk/pdbe-srv/view/entry/1G8R PDB 2NQK http://www.ebi.ac.uk/pdbe-srv/view/entry/2NQK PDB 2NQM http://www.ebi.ac.uk/pdbe-srv/view/entry/2NQM PDB 2NQN http://www.ebi.ac.uk/pdbe-srv/view/entry/2NQN PDB 2NQQ http://www.ebi.ac.uk/pdbe-srv/view/entry/2NQQ PDB 2NQR http://www.ebi.ac.uk/pdbe-srv/view/entry/2NQR PDB 2NQS http://www.ebi.ac.uk/pdbe-srv/view/entry/2NQS PDB 2NQU http://www.ebi.ac.uk/pdbe-srv/view/entry/2NQU PDB 2NQV http://www.ebi.ac.uk/pdbe-srv/view/entry/2NQV PDB 2NRO http://www.ebi.ac.uk/pdbe-srv/view/entry/2NRO PDB 2NRP http://www.ebi.ac.uk/pdbe-srv/view/entry/2NRP PDB 2NRS http://www.ebi.ac.uk/pdbe-srv/view/entry/2NRS PDBsum 1FC5 http://www.ebi.ac.uk/pdbsum/1FC5 PDBsum 1G8L http://www.ebi.ac.uk/pdbsum/1G8L PDBsum 1G8R http://www.ebi.ac.uk/pdbsum/1G8R PDBsum 2NQK http://www.ebi.ac.uk/pdbsum/2NQK PDBsum 2NQM http://www.ebi.ac.uk/pdbsum/2NQM PDBsum 2NQN http://www.ebi.ac.uk/pdbsum/2NQN PDBsum 2NQQ http://www.ebi.ac.uk/pdbsum/2NQQ PDBsum 2NQR http://www.ebi.ac.uk/pdbsum/2NQR PDBsum 2NQS http://www.ebi.ac.uk/pdbsum/2NQS PDBsum 2NQU http://www.ebi.ac.uk/pdbsum/2NQU PDBsum 2NQV http://www.ebi.ac.uk/pdbsum/2NQV PDBsum 2NRO http://www.ebi.ac.uk/pdbsum/2NRO PDBsum 2NRP http://www.ebi.ac.uk/pdbsum/2NRP PDBsum 2NRS http://www.ebi.ac.uk/pdbsum/2NRS PROSITE PS01079 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01079 PSORT swissprot:MOEA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MOEA_ECOLI PSORT-B swissprot:MOEA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MOEA_ECOLI PSORT2 swissprot:MOEA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MOEA_ECOLI Pfam PF00994 http://pfam.xfam.org/family/PF00994 Pfam PF03453 http://pfam.xfam.org/family/PF03453 Pfam PF03454 http://pfam.xfam.org/family/PF03454 Phobius swissprot:MOEA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MOEA_ECOLI PhylomeDB P12281 http://phylomedb.org/?seqid=P12281 ProteinModelPortal P12281 http://www.proteinmodelportal.org/query/uniprot/P12281 PubMed 11428898 http://www.ncbi.nlm.nih.gov/pubmed/11428898 PubMed 11525167 http://www.ncbi.nlm.nih.gov/pubmed/11525167 PubMed 12372836 http://www.ncbi.nlm.nih.gov/pubmed/12372836 PubMed 15632135 http://www.ncbi.nlm.nih.gov/pubmed/15632135 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3045084 http://www.ncbi.nlm.nih.gov/pubmed/3045084 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9515915 http://www.ncbi.nlm.nih.gov/pubmed/9515915 RefSeq NP_415348 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415348 RefSeq WP_000397340 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000397340 SMART SM00852 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00852 SMR P12281 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P12281 STRING 511145.b0827 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0827&targetmode=cogs STRING COG0303 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0303&targetmode=cogs SUPFAM SSF53218 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53218 SUPFAM SSF63867 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63867 SUPFAM SSF63882 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63882 TIGRFAMs TIGR00177 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00177 UniProtKB MOEA_ECOLI http://www.uniprot.org/uniprot/MOEA_ECOLI UniProtKB-AC P12281 http://www.uniprot.org/uniprot/P12281 charge swissprot:MOEA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MOEA_ECOLI eggNOG COG0303 http://eggnogapi.embl.de/nog_data/html/tree/COG0303 eggNOG ENOG4105CVM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CVM epestfind swissprot:MOEA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MOEA_ECOLI garnier swissprot:MOEA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MOEA_ECOLI helixturnhelix swissprot:MOEA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MOEA_ECOLI hmoment swissprot:MOEA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MOEA_ECOLI iep swissprot:MOEA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MOEA_ECOLI inforesidue swissprot:MOEA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MOEA_ECOLI octanol swissprot:MOEA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MOEA_ECOLI pepcoil swissprot:MOEA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MOEA_ECOLI pepdigest swissprot:MOEA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MOEA_ECOLI pepinfo swissprot:MOEA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MOEA_ECOLI pepnet swissprot:MOEA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MOEA_ECOLI pepstats swissprot:MOEA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MOEA_ECOLI pepwheel swissprot:MOEA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MOEA_ECOLI pepwindow swissprot:MOEA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MOEA_ECOLI sigcleave swissprot:MOEA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MOEA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261796 153 # EcoGene EG11154 ppdC # FUNCTION PPDC_ECOLI Not yet known. # InterPro IPR012902 N_methyl_site # InterPro IPR022204 DUF3728 # KEGG_Brite ko02044 Secretion system # Organism PPDC_ECOLI Escherichia coli (strain K12) # PATRIC 32121064 VBIEscCol129921_2921 # PIR E24137 QQEC12 # PROSITE PS00409 PROKAR_NTER_METHYL # Pfam PF07963 N_methyl # Pfam PF12528 T2SSppdC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PPDC_ECOLI Prepilin peptidase-dependent protein C # RefSeq NP_417300 NC_000913.3 # RefSeq WP_001276460 NZ_LN832404.1 # TIGRFAMs TIGR02532 IV_pilin_GFxxxE # eggNOG COG4967 LUCA # eggNOG ENOG4105RVB Bacteria BLAST swissprot:PPDC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PPDC_ECOLI BioCyc ECOL316407:JW2791-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2791-MONOMER BioCyc EcoCyc:EG11154-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11154-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/14.11.4437 http://dx.doi.org/10.1093/nar/14.11.4437 DOI 10.1111/j.1365-2958.1993.tb01949.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb01949.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 EMBL X03966 http://www.ebi.ac.uk/ena/data/view/X03966 EchoBASE EB1143 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1143 EcoGene EG11154 http://www.ecogene.org/geneInfo.php?eg_id=EG11154 EnsemblBacteria AAC75862 http://www.ensemblgenomes.org/id/AAC75862 EnsemblBacteria AAC75862 http://www.ensemblgenomes.org/id/AAC75862 EnsemblBacteria BAE76892 http://www.ensemblgenomes.org/id/BAE76892 EnsemblBacteria BAE76892 http://www.ensemblgenomes.org/id/BAE76892 EnsemblBacteria BAE76892 http://www.ensemblgenomes.org/id/BAE76892 EnsemblBacteria b2823 http://www.ensemblgenomes.org/id/b2823 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945797 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945797 HOGENOM HOG000124335 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000124335&db=HOGENOM6 InterPro IPR012902 http://www.ebi.ac.uk/interpro/entry/IPR012902 InterPro IPR022204 http://www.ebi.ac.uk/interpro/entry/IPR022204 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW2791 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2791 KEGG_Gene eco:b2823 http://www.genome.jp/dbget-bin/www_bget?eco:b2823 KEGG_Orthology KO:K02681 http://www.genome.jp/dbget-bin/www_bget?KO:K02681 OMA QRTSMNS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QRTSMNS PROSITE PS00409 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00409 PSORT swissprot:PPDC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PPDC_ECOLI PSORT-B swissprot:PPDC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PPDC_ECOLI PSORT2 swissprot:PPDC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PPDC_ECOLI Pfam PF07963 http://pfam.xfam.org/family/PF07963 Pfam PF12528 http://pfam.xfam.org/family/PF12528 Phobius swissprot:PPDC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PPDC_ECOLI ProteinModelPortal P08372 http://www.proteinmodelportal.org/query/uniprot/P08372 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3520484 http://www.ncbi.nlm.nih.gov/pubmed/3520484 PubMed 7934814 http://www.ncbi.nlm.nih.gov/pubmed/7934814 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417300 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417300 RefSeq WP_001276460 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001276460 STRING 511145.b2823 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2823&targetmode=cogs TIGRFAMs TIGR02532 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02532 UniProtKB PPDC_ECOLI http://www.uniprot.org/uniprot/PPDC_ECOLI UniProtKB-AC P08372 http://www.uniprot.org/uniprot/P08372 charge swissprot:PPDC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PPDC_ECOLI eggNOG COG4967 http://eggnogapi.embl.de/nog_data/html/tree/COG4967 eggNOG ENOG4105RVB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105RVB epestfind swissprot:PPDC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PPDC_ECOLI garnier swissprot:PPDC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PPDC_ECOLI helixturnhelix swissprot:PPDC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PPDC_ECOLI hmoment swissprot:PPDC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PPDC_ECOLI iep swissprot:PPDC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PPDC_ECOLI inforesidue swissprot:PPDC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PPDC_ECOLI octanol swissprot:PPDC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PPDC_ECOLI pepcoil swissprot:PPDC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PPDC_ECOLI pepdigest swissprot:PPDC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PPDC_ECOLI pepinfo swissprot:PPDC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PPDC_ECOLI pepnet swissprot:PPDC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PPDC_ECOLI pepstats swissprot:PPDC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PPDC_ECOLI pepwheel swissprot:PPDC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PPDC_ECOLI pepwindow swissprot:PPDC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PPDC_ECOLI sigcleave swissprot:PPDC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PPDC_ECOLI ## Database ID URL or Descriptions # BioGrid 4261059 6 # EcoGene EG11661 yedF # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_process GO:0006950 response to stress # Gene3D 3.30.110.40 -; 1. # IntAct P0AA31 4 # InterPro IPR001455 TusA-like # Organism YEDF_ECOLI Escherichia coli (strain K12) # PATRIC 32119195 VBIEscCol129921_2012 # PDB 1JE3 NMR; -; A=1-77 # PIR G64956 G64956 # PROSITE PS01148 UPF0033 # Pfam PF01206 TusA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEDF_ECOLI UPF0033 protein YedF # RefSeq NP_416440 NC_000913.3 # RefSeq WP_000790504 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0033 family. {ECO 0000305}. # SUPFAM SSF64307 SSF64307 # eggNOG COG0425 LUCA BLAST swissprot:YEDF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEDF_ECOLI BioCyc ECOL316407:JW1915-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1915-MONOMER BioCyc EcoCyc:EG11661-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11661-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.042684599 http://dx.doi.org/10.1073/pnas.042684599 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1099/00221287-139-7-1401 http://dx.doi.org/10.1099/00221287-139-7-1401 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L13279 http://www.ebi.ac.uk/ena/data/view/L13279 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1613 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1613 EcoGene EG11661 http://www.ecogene.org/geneInfo.php?eg_id=EG11661 EnsemblBacteria AAC74997 http://www.ensemblgenomes.org/id/AAC74997 EnsemblBacteria AAC74997 http://www.ensemblgenomes.org/id/AAC74997 EnsemblBacteria BAA15758 http://www.ensemblgenomes.org/id/BAA15758 EnsemblBacteria BAA15758 http://www.ensemblgenomes.org/id/BAA15758 EnsemblBacteria BAA15758 http://www.ensemblgenomes.org/id/BAA15758 EnsemblBacteria b1930 http://www.ensemblgenomes.org/id/b1930 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.30.110.40 http://www.cathdb.info/version/latest/superfamily/3.30.110.40 GeneID 23338749 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23338749 GeneID 946909 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946909 HOGENOM HOG000259289 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000259289&db=HOGENOM6 InParanoid P0AA31 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AA31 IntAct P0AA31 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AA31* InterPro IPR001455 http://www.ebi.ac.uk/interpro/entry/IPR001455 KEGG_Gene ecj:JW1915 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1915 KEGG_Gene eco:b1930 http://www.genome.jp/dbget-bin/www_bget?eco:b1930 OMA IISDCPQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IISDCPQ PDB 1JE3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1JE3 PDBsum 1JE3 http://www.ebi.ac.uk/pdbsum/1JE3 PROSITE PS01148 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01148 PSORT swissprot:YEDF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEDF_ECOLI PSORT-B swissprot:YEDF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEDF_ECOLI PSORT2 swissprot:YEDF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEDF_ECOLI Pfam PF01206 http://pfam.xfam.org/family/PF01206 Phobius swissprot:YEDF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEDF_ECOLI PhylomeDB P0AA31 http://phylomedb.org/?seqid=P0AA31 ProteinModelPortal P0AA31 http://www.proteinmodelportal.org/query/uniprot/P0AA31 PubMed 11854485 http://www.ncbi.nlm.nih.gov/pubmed/11854485 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8371104 http://www.ncbi.nlm.nih.gov/pubmed/8371104 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416440 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416440 RefSeq WP_000790504 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000790504 SMR P0AA31 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AA31 STRING 511145.b1930 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1930&targetmode=cogs SUPFAM SSF64307 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF64307 UniProtKB YEDF_ECOLI http://www.uniprot.org/uniprot/YEDF_ECOLI UniProtKB-AC P0AA31 http://www.uniprot.org/uniprot/P0AA31 charge swissprot:YEDF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEDF_ECOLI eggNOG COG0425 http://eggnogapi.embl.de/nog_data/html/tree/COG0425 epestfind swissprot:YEDF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEDF_ECOLI garnier swissprot:YEDF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEDF_ECOLI helixturnhelix swissprot:YEDF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEDF_ECOLI hmoment swissprot:YEDF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEDF_ECOLI iep swissprot:YEDF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEDF_ECOLI inforesidue swissprot:YEDF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEDF_ECOLI octanol swissprot:YEDF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEDF_ECOLI pepcoil swissprot:YEDF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEDF_ECOLI pepdigest swissprot:YEDF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEDF_ECOLI pepinfo swissprot:YEDF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEDF_ECOLI pepnet swissprot:YEDF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEDF_ECOLI pepstats swissprot:YEDF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEDF_ECOLI pepwheel swissprot:YEDF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEDF_ECOLI pepwindow swissprot:YEDF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEDF_ECOLI sigcleave swissprot:YEDF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEDF_ECOLI ## Database ID URL or Descriptions # BioGrid 4261263 7 # CATALYTIC ACTIVITY PHSG_ECOLI ((1->4)-alpha-D-glucosyl)(n) + phosphate = ((1->4)-alpha-D-glucosyl)(n-1) + alpha-D-glucose 1-phosphate. # CDD cd04300 GT1_Glycogen_Phosphorylase # COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI 597326; # EcoGene EG10380 glgP # FUNCTION PHSG_ECOLI Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0008184 glycogen phosphorylase activity; IDA:EcoCyc. # GO_function GO:0030170 pyridoxal phosphate binding; IDA:EcoCyc. # GO_process GO:0005980 glycogen catabolic process; IMP:EcoCyc. # GO_process GO:0016052 carbohydrate catabolic process; IDA:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0009056 catabolic process # InterPro IPR000811 Glyco_trans_35 # InterPro IPR011833 Glycg_phsphrylas # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00500 Starch and sucrose metabolism # KEGG_Pathway ko04910 Insulin signaling pathway # Organism PHSG_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11468 PTHR11468 # PATRIC 32122296 VBIEscCol129921_3525 # PIR G65138 PHECGG # PIRSF PIRSF000460 Pprylas_GlgP # PROSITE PS00102 PHOSPHORYLASE # Pfam PF00343 Phosphorylase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PHSG_ECOLI Glycogen phosphorylase # RefSeq NP_417886 NC_000913.3 # RefSeq WP_000993449 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA34807.1; Type=Frameshift; Positions=9; Evidence={ECO 0000305}; # SIMILARITY Belongs to the glycogen phosphorylase family. {ECO 0000305}. # TIGRFAMs TIGR02093 P_ylase # eggNOG COG0058 LUCA # eggNOG ENOG4107QQN Bacteria BLAST swissprot:PHSG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PHSG_ECOLI BioCyc ECOL316407:JW3391-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3391-MONOMER BioCyc EcoCyc:GLYCOPHOSPHORYL-MONOMER http://biocyc.org/getid?id=EcoCyc:GLYCOPHOSPHORYL-MONOMER BioCyc MetaCyc:GLYCOPHOSPHORYL-MONOMER http://biocyc.org/getid?id=MetaCyc:GLYCOPHOSPHORYL-MONOMER COG COG0058 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0058 DIP DIP-47899N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47899N DOI 10.1016/0014-5793(89)80128-0 http://dx.doi.org/10.1016/0014-5793(89)80128-0 DOI 10.1016/0378-1119(88)90208-9 http://dx.doi.org/10.1016/0378-1119(88)90208-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.4.1.1 http://www.genome.jp/dbget-bin/www_bget?EC:2.4.1.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D00425 http://www.ebi.ac.uk/ena/data/view/D00425 EMBL J02616 http://www.ebi.ac.uk/ena/data/view/J02616 EMBL J03966 http://www.ebi.ac.uk/ena/data/view/J03966 EMBL M22368 http://www.ebi.ac.uk/ena/data/view/M22368 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X16931 http://www.ebi.ac.uk/ena/data/view/X16931 ENZYME 2.4.1.1 http://enzyme.expasy.org/EC/2.4.1.1 EchoBASE EB0375 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0375 EcoGene EG10380 http://www.ecogene.org/geneInfo.php?eg_id=EG10380 EnsemblBacteria AAC76453 http://www.ensemblgenomes.org/id/AAC76453 EnsemblBacteria AAC76453 http://www.ensemblgenomes.org/id/AAC76453 EnsemblBacteria BAE77864 http://www.ensemblgenomes.org/id/BAE77864 EnsemblBacteria BAE77864 http://www.ensemblgenomes.org/id/BAE77864 EnsemblBacteria BAE77864 http://www.ensemblgenomes.org/id/BAE77864 EnsemblBacteria b3428 http://www.ensemblgenomes.org/id/b3428 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0008184 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008184 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_process GO:0005980 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005980 GO_process GO:0016052 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016052 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GeneID 947931 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947931 HOGENOM HOG000278444 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278444&db=HOGENOM6 InParanoid P0AC86 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AC86 IntAct P0AC86 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AC86* IntEnz 2.4.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.1.1 InterPro IPR000811 http://www.ebi.ac.uk/interpro/entry/IPR000811 InterPro IPR011833 http://www.ebi.ac.uk/interpro/entry/IPR011833 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3391 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3391 KEGG_Gene eco:b3428 http://www.genome.jp/dbget-bin/www_bget?eco:b3428 KEGG_Orthology KO:K00688 http://www.genome.jp/dbget-bin/www_bget?KO:K00688 KEGG_Pathway ko00500 http://www.genome.jp/kegg-bin/show_pathway?ko00500 KEGG_Pathway ko04910 http://www.genome.jp/kegg-bin/show_pathway?ko04910 KEGG_Reaction rn:R02111 http://www.genome.jp/dbget-bin/www_bget?rn:R02111 MINT MINT-1307808 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1307808 OMA RMAWFSS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RMAWFSS PANTHER PTHR11468 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11468 PROSITE PS00102 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00102 PSORT swissprot:PHSG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PHSG_ECOLI PSORT-B swissprot:PHSG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PHSG_ECOLI PSORT2 swissprot:PHSG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PHSG_ECOLI Pfam PF00343 http://pfam.xfam.org/family/PF00343 Phobius swissprot:PHSG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PHSG_ECOLI PhylomeDB P0AC86 http://phylomedb.org/?seqid=P0AC86 ProteinModelPortal P0AC86 http://www.proteinmodelportal.org/query/uniprot/P0AC86 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2645169 http://www.ncbi.nlm.nih.gov/pubmed/2645169 PubMed 2975249 http://www.ncbi.nlm.nih.gov/pubmed/2975249 PubMed 3047129 http://www.ncbi.nlm.nih.gov/pubmed/3047129 PubMed 3097003 http://www.ncbi.nlm.nih.gov/pubmed/3097003 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417886 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417886 RefSeq WP_000993449 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000993449 SMR P0AC86 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AC86 STRING 511145.b3428 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3428&targetmode=cogs STRING COG0058 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0058&targetmode=cogs TIGRFAMs TIGR02093 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02093 UniProtKB PHSG_ECOLI http://www.uniprot.org/uniprot/PHSG_ECOLI UniProtKB-AC P0AC86 http://www.uniprot.org/uniprot/P0AC86 charge swissprot:PHSG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PHSG_ECOLI eggNOG COG0058 http://eggnogapi.embl.de/nog_data/html/tree/COG0058 eggNOG ENOG4107QQN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QQN epestfind swissprot:PHSG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PHSG_ECOLI garnier swissprot:PHSG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PHSG_ECOLI helixturnhelix swissprot:PHSG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PHSG_ECOLI hmoment swissprot:PHSG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PHSG_ECOLI iep swissprot:PHSG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PHSG_ECOLI inforesidue swissprot:PHSG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PHSG_ECOLI octanol swissprot:PHSG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PHSG_ECOLI pepcoil swissprot:PHSG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PHSG_ECOLI pepdigest swissprot:PHSG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PHSG_ECOLI pepinfo swissprot:PHSG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PHSG_ECOLI pepnet swissprot:PHSG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PHSG_ECOLI pepstats swissprot:PHSG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PHSG_ECOLI pepwheel swissprot:PHSG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PHSG_ECOLI pepwindow swissprot:PHSG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PHSG_ECOLI sigcleave swissprot:PHSG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PHSG_ECOLI ## Database ID URL or Descriptions # AltName Queuosine biosynthesis protein QueE {ECO:0000255|HAMAP-Rule MF_00917} # BioGrid 4262295 19 # CATALYTIC ACTIVITY 6-carboxy-5,6,7,8-tetrahydropterin = 7- carboxy-7-carbaguanine + NH(3). {ECO:0000255|HAMAP-Rule MF_00917}. # COFACTOR QUEE_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_00917}; # COFACTOR QUEE_ECOLI Name=S-adenosyl-L-methionine; Xref=ChEBI CHEBI 59789; Evidence={ECO 0000255|HAMAP-Rule MF_00917}; Note=Binds 1 S-adenosyl-L-methionine per subunit. {ECO 0000255|HAMAP-Rule MF_00917}; # COFACTOR QUEE_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000255|HAMAP-Rule MF_00917}; Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. {ECO 0000255|HAMAP-Rule MF_00917}; # EcoGene EG13034 queE # FUNCTION QUEE_ECOLI Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. {ECO 0000255|HAMAP-Rule MF_00917}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0016840 carbon-nitrogen lyase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-HAMAP. # GO_function GO:1904047 S-adenosyl-L-methionine binding; IEA:UniProtKB-HAMAP. # GO_process GO:0008616 queuosine biosynthetic process; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.70 -; 1. # HAMAP MF_00917 QueE # IntAct P64554 2 # InterPro IPR007197 rSAM # InterPro IPR013785 Aldolase_TIM # InterPro IPR024924 7-CO-7-deazaguanine_synth-like # InterPro IPR027609 rSAM_QueE_Proteobac # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # Organism QUEE_ECOLI Escherichia coli (strain K12) # PATHWAY Purine metabolism; 7-cyano-7-deazaguanine biosynthesis. {ECO:0000255|HAMAP-Rule MF_00917}. # PATRIC 32120968 VBIEscCol129921_2876 # PIR E65059 E65059 # PIRSF PIRSF000370 QueE # Pfam PF04055 Radical_SAM # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 7-carboxy-7-deazaguanine synthase {ECO:0000255|HAMAP-Rule MF_00917} # RefSeq NP_417257 NC_000913.3 # RefSeq WP_001199973 NZ_LN832404.1 # SIMILARITY Belongs to the radical SAM superfamily. 7-carboxy-7- deazaguanine synthase family. {ECO:0000255|HAMAP-Rule MF_00917}. # SUBUNIT Homodimer. {ECO:0000255|HAMAP-Rule MF_00917}. # TIGRFAMs TIGR04322 rSAM_QueE_Ecoli # eggNOG COG0602 LUCA # eggNOG ENOG4105EIZ Bacteria BLAST swissprot:QUEE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:QUEE_ECOLI BioCyc ECOL316407:JW2748-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2748-MONOMER BioCyc EcoCyc:G7443-MONOMER http://biocyc.org/getid?id=EcoCyc:G7443-MONOMER COG COG0602 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0602 DIP DIP-48192N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48192N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.3.99.3 {ECO:0000255|HAMAP-Rule:MF_00917} http://www.genome.jp/dbget-bin/www_bget?EC:4.3.99.3 {ECO:0000255|HAMAP-Rule:MF_00917} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29580 http://www.ebi.ac.uk/ena/data/view/U29580 ENZYME 4.3.99.3 {ECO:0000255|HAMAP-Rule:MF_00917} http://enzyme.expasy.org/EC/4.3.99.3 {ECO:0000255|HAMAP-Rule:MF_00917} EchoBASE EB2849 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2849 EcoGene EG13034 http://www.ecogene.org/geneInfo.php?eg_id=EG13034 EnsemblBacteria AAC75819 http://www.ensemblgenomes.org/id/AAC75819 EnsemblBacteria AAC75819 http://www.ensemblgenomes.org/id/AAC75819 EnsemblBacteria BAE76851 http://www.ensemblgenomes.org/id/BAE76851 EnsemblBacteria BAE76851 http://www.ensemblgenomes.org/id/BAE76851 EnsemblBacteria BAE76851 http://www.ensemblgenomes.org/id/BAE76851 EnsemblBacteria b2777 http://www.ensemblgenomes.org/id/b2777 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0016840 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016840 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_function GO:1904047 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1904047 GO_process GO:0008616 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008616 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 947527 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947527 HAMAP MF_00917 http://hamap.expasy.org/unirule/MF_00917 HOGENOM HOG000266143 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000266143&db=HOGENOM6 InParanoid P64554 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P64554 IntAct P64554 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P64554* IntEnz 4.3.99.3 {ECO:0000255|HAMAP-Rule:MF_00917} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.3.99.3 {ECO:0000255|HAMAP-Rule:MF_00917} InterPro IPR007197 http://www.ebi.ac.uk/interpro/entry/IPR007197 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR024924 http://www.ebi.ac.uk/interpro/entry/IPR024924 InterPro IPR027609 http://www.ebi.ac.uk/interpro/entry/IPR027609 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW2748 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2748 KEGG_Gene eco:b2777 http://www.genome.jp/dbget-bin/www_bget?eco:b2777 KEGG_Orthology KO:K10026 http://www.genome.jp/dbget-bin/www_bget?KO:K10026 KEGG_Reaction rn:R10002 http://www.genome.jp/dbget-bin/www_bget?rn:R10002 OMA PCIHDLT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PCIHDLT PSORT swissprot:QUEE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:QUEE_ECOLI PSORT-B swissprot:QUEE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:QUEE_ECOLI PSORT2 swissprot:QUEE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:QUEE_ECOLI Pfam PF04055 http://pfam.xfam.org/family/PF04055 Phobius swissprot:QUEE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:QUEE_ECOLI PhylomeDB P64554 http://phylomedb.org/?seqid=P64554 ProteinModelPortal P64554 http://www.proteinmodelportal.org/query/uniprot/P64554 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417257 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417257 RefSeq WP_001199973 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001199973 STRING 511145.b2777 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2777&targetmode=cogs STRING COG0602 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0602&targetmode=cogs TIGRFAMs TIGR04322 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR04322 UniProtKB QUEE_ECOLI http://www.uniprot.org/uniprot/QUEE_ECOLI UniProtKB-AC P64554 http://www.uniprot.org/uniprot/P64554 charge swissprot:QUEE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:QUEE_ECOLI eggNOG COG0602 http://eggnogapi.embl.de/nog_data/html/tree/COG0602 eggNOG ENOG4105EIZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EIZ epestfind swissprot:QUEE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:QUEE_ECOLI garnier swissprot:QUEE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:QUEE_ECOLI helixturnhelix swissprot:QUEE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:QUEE_ECOLI hmoment swissprot:QUEE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:QUEE_ECOLI iep swissprot:QUEE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:QUEE_ECOLI inforesidue swissprot:QUEE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:QUEE_ECOLI octanol swissprot:QUEE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:QUEE_ECOLI pepcoil swissprot:QUEE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:QUEE_ECOLI pepdigest swissprot:QUEE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:QUEE_ECOLI pepinfo swissprot:QUEE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:QUEE_ECOLI pepnet swissprot:QUEE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:QUEE_ECOLI pepstats swissprot:QUEE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:QUEE_ECOLI pepwheel swissprot:QUEE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:QUEE_ECOLI pepwindow swissprot:QUEE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:QUEE_ECOLI sigcleave swissprot:QUEE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:QUEE_ECOLI ## Database ID URL or Descriptions # CAUTION It is uncertain whether Met-1 or Met-5 is the initiator. {ECO 0000305}. # FUNCTION TRBC_ECOLI Essential for F plasmid conjugative transfer, participates in F-pilus assembly. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_process GO:0000746 conjugation; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0008150 biological_process # InterPro IPR014113 T4SS_TrbC_subgr # InterPro IPR019106 T4SS_TrbC # Organism TRBC_ECOLI Escherichia coli (strain K12) # PIR A39442 A39442 # Pfam PF09673 TrbC_Ftype # RecName TRBC_ECOLI Periplasmic protein TrbC # RefSeq NP_061467 NC_002483.1 # RefSeq WP_000777688 NZ_CP014273.1 # RefSeq YP_009060143 NC_024956.1 # RefSeq YP_009070601 NC_025175.1 # SUBCELLULAR LOCATION TRBC_ECOLI Periplasm. # TIGRFAMs TIGR02742 TrbC_Ftype BLAST swissprot:TRBC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRBC_ECOLI DOI 10.1016/0022-2836(92)90923-8 http://dx.doi.org/10.1016/0022-2836(92)90923-8 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL M34695 http://www.ebi.ac.uk/ena/data/view/M34695 EMBL M60427 http://www.ebi.ac.uk/ena/data/view/M60427 EMBL U01159 http://www.ebi.ac.uk/ena/data/view/U01159 EMBL X61575 http://www.ebi.ac.uk/ena/data/view/X61575 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_process GO:0000746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000746 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 1263546 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263546 GeneID 20466896 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20466896 GeneID 20492669 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20492669 InterPro IPR014113 http://www.ebi.ac.uk/interpro/entry/IPR014113 InterPro IPR019106 http://www.ebi.ac.uk/interpro/entry/IPR019106 OMA ALLMMLN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ALLMMLN PSORT swissprot:TRBC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRBC_ECOLI PSORT-B swissprot:TRBC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRBC_ECOLI PSORT2 swissprot:TRBC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRBC_ECOLI Pfam PF09673 http://pfam.xfam.org/family/PF09673 Phobius swissprot:TRBC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRBC_ECOLI ProteinModelPortal P18473 http://www.proteinmodelportal.org/query/uniprot/P18473 PubMed 1593622 http://www.ncbi.nlm.nih.gov/pubmed/1593622 PubMed 2050638 http://www.ncbi.nlm.nih.gov/pubmed/2050638 PubMed 2198250 http://www.ncbi.nlm.nih.gov/pubmed/2198250 PubMed 7915817 http://www.ncbi.nlm.nih.gov/pubmed/7915817 RefSeq NP_061467 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061467 RefSeq WP_000777688 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000777688 RefSeq YP_009060143 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009060143 RefSeq YP_009070601 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009070601 TIGRFAMs TIGR02742 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02742 UniProtKB TRBC_ECOLI http://www.uniprot.org/uniprot/TRBC_ECOLI UniProtKB-AC P18473 http://www.uniprot.org/uniprot/P18473 charge swissprot:TRBC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRBC_ECOLI epestfind swissprot:TRBC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRBC_ECOLI garnier swissprot:TRBC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRBC_ECOLI helixturnhelix swissprot:TRBC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRBC_ECOLI hmoment swissprot:TRBC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRBC_ECOLI iep swissprot:TRBC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRBC_ECOLI inforesidue swissprot:TRBC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRBC_ECOLI octanol swissprot:TRBC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRBC_ECOLI pepcoil swissprot:TRBC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRBC_ECOLI pepdigest swissprot:TRBC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRBC_ECOLI pepinfo swissprot:TRBC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRBC_ECOLI pepnet swissprot:TRBC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRBC_ECOLI pepstats swissprot:TRBC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRBC_ECOLI pepwheel swissprot:TRBC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRBC_ECOLI pepwindow swissprot:TRBC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRBC_ECOLI sigcleave swissprot:TRBC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRBC_ECOLI ## Database ID URL or Descriptions # AltName SATP_ECOLI Succinate-acetate transporter protein # BIOPHYSICOCHEMICAL PROPERTIES SATP_ECOLI Kinetic parameters KM=1.24 mM for acetic acid {ECO 0000269|PubMed 23844911}; KM=1.18 mM for succinic acid {ECO 0000269|PubMed 23844911}; Vmax=8.72 nmol/min/mg enzyme with acetic acid as substrate {ECO 0000269|PubMed 23844911}; Vmax=10.05 nmol/min/mg enzyme with succinic acid as substrate {ECO 0000269|PubMed 23844911}; pH dependence Optimum pH is 6.0. {ECO 0000269|PubMed 23844911}; # DISRUPTION PHENOTYPE Mutant shows a partial reduction in acetate uptake. {ECO:0000269|PubMed 23844911}. # ENZYME REGULATION Transport is inhibited by the protonophore CCCP. {ECO:0000269|PubMed 23844911}. # EcoGene EG11512 satP # FUNCTION SATP_ECOLI Uptake of acetate and succinate. Transport is energetically dependent on the protonmotive force. {ECO 0000269|PubMed 23844911}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function SATP_ECOLI GO 0015360 acetate proton symporter activity; IDA EcoCyc. # GO_process GO:0035433 acetate transmembrane transport; IMP:EcoCyc. # GO_process GO:0071422 succinate transmembrane transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0055085 transmembrane transport # InterPro IPR000791 Grp1/Fun34/SatP # Organism SATP_ECOLI Escherichia coli (strain K12) # PATRIC 32115115 VBIEscCol129921_0009 # PIR E56688 E56688 # PROSITE PS01114 GPR1_FUN34_YAAH # Pfam PF01184 Grp1_Fun34_YaaH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SATP_ECOLI Succinate-acetate/proton symporter SatP # RefSeq NP_414551 NC_000913.3 # RefSeq WP_000528538 NZ_LN832404.1 # SIMILARITY Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family. {ECO 0000305}. # SUBCELLULAR LOCATION SATP_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # TCDB 2.A.96.1 2.a.96. the acetate uptake transporter (acetr) family # eggNOG COG1584 LUCA # eggNOG ENOG4106HK8 Bacteria BLAST swissprot:SATP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SATP_ECOLI BioCyc ECOL316407:JW0009-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0009-MONOMER BioCyc EcoCyc:EG11512-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11512-MONOMER BioCyc MetaCyc:EG11512-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11512-MONOMER COG COG1584 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1584 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/BJ20130412 http://dx.doi.org/10.1042/BJ20130412 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X67700 http://www.ebi.ac.uk/ena/data/view/X67700 EchoBASE EB1474 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1474 EcoGene EG11512 http://www.ecogene.org/geneInfo.php?eg_id=EG11512 EnsemblBacteria AAC73121 http://www.ensemblgenomes.org/id/AAC73121 EnsemblBacteria AAC73121 http://www.ensemblgenomes.org/id/AAC73121 EnsemblBacteria BAB96588 http://www.ensemblgenomes.org/id/BAB96588 EnsemblBacteria BAB96588 http://www.ensemblgenomes.org/id/BAB96588 EnsemblBacteria BAB96588 http://www.ensemblgenomes.org/id/BAB96588 EnsemblBacteria b0010 http://www.ensemblgenomes.org/id/b0010 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015360 GO_process GO:0035433 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035433 GO_process GO:0071422 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071422 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 944792 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944792 HOGENOM HOG000224166 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000224166&db=HOGENOM6 InParanoid P0AC98 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AC98 InterPro IPR000791 http://www.ebi.ac.uk/interpro/entry/IPR000791 KEGG_Gene ecj:JW0009 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0009 KEGG_Gene eco:b0010 http://www.genome.jp/dbget-bin/www_bget?eco:b0010 KEGG_Orthology KO:K07034 http://www.genome.jp/dbget-bin/www_bget?KO:K07034 OMA AQFLGVF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AQFLGVF PROSITE PS01114 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01114 PSORT swissprot:SATP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SATP_ECOLI PSORT-B swissprot:SATP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SATP_ECOLI PSORT2 swissprot:SATP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SATP_ECOLI Pfam PF01184 http://pfam.xfam.org/family/PF01184 Phobius swissprot:SATP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SATP_ECOLI PhylomeDB P0AC98 http://phylomedb.org/?seqid=P0AC98 ProteinModelPortal P0AC98 http://www.proteinmodelportal.org/query/uniprot/P0AC98 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 23844911 http://www.ncbi.nlm.nih.gov/pubmed/23844911 PubMed 8400364 http://www.ncbi.nlm.nih.gov/pubmed/8400364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414551 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414551 RefSeq WP_000528538 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000528538 STRING 511145.b0010 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0010&targetmode=cogs STRING COG1584 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1584&targetmode=cogs TCDB 2.A.96.1 http://www.tcdb.org/search/result.php?tc=2.A.96.1 UniProtKB SATP_ECOLI http://www.uniprot.org/uniprot/SATP_ECOLI UniProtKB-AC P0AC98 http://www.uniprot.org/uniprot/P0AC98 charge swissprot:SATP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SATP_ECOLI eggNOG COG1584 http://eggnogapi.embl.de/nog_data/html/tree/COG1584 eggNOG ENOG4106HK8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106HK8 epestfind swissprot:SATP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SATP_ECOLI garnier swissprot:SATP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SATP_ECOLI helixturnhelix swissprot:SATP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SATP_ECOLI hmoment swissprot:SATP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SATP_ECOLI iep swissprot:SATP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SATP_ECOLI inforesidue swissprot:SATP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SATP_ECOLI octanol swissprot:SATP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SATP_ECOLI pepcoil swissprot:SATP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SATP_ECOLI pepdigest swissprot:SATP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SATP_ECOLI pepinfo swissprot:SATP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SATP_ECOLI pepnet swissprot:SATP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SATP_ECOLI pepstats swissprot:SATP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SATP_ECOLI pepwheel swissprot:SATP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SATP_ECOLI pepwindow swissprot:SATP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SATP_ECOLI sigcleave swissprot:SATP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SATP_ECOLI ## Database ID URL or Descriptions # BioGrid 4261650 8 # EcoGene EG12545 yjhC # GO_function GO:0016491 oxidoreductase activity; IBA:GO_Central. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0055114 oxidation-reduction process; IBA:GO_Central. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.720 -; 1. # IntAct P39353 2 # InterPro IPR000683 Oxidoreductase_N # InterPro IPR004104 OxRdtase_C # InterPro IPR016040 NAD(P)-bd_dom # Organism YJHC_ECOLI Escherichia coli (strain K12) # PATRIC 32124133 VBIEscCol129921_4410 # PIR S56505 S56505 # Pfam PF01408 GFO_IDH_MocA # Pfam PF02894 GFO_IDH_MocA_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJHC_ECOLI Uncharacterized oxidoreductase YjhC # RefSeq NP_418700 NC_000913.3 # RefSeq WP_000611568 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97176.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the Gfo/Idh/MocA family. {ECO 0000305}. # SUPFAM SSF51735 SSF51735 # eggNOG COG0673 LUCA # eggNOG ENOG4107RJ5 Bacteria BLAST swissprot:YJHC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJHC_ECOLI BioCyc ECOL316407:JW5769-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5769-MONOMER BioCyc EcoCyc:G7901-MONOMER http://biocyc.org/getid?id=EcoCyc:G7901-MONOMER DIP DIP-12617N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12617N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- EchoBASE EB2433 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2433 EcoGene EG12545 http://www.ecogene.org/geneInfo.php?eg_id=EG12545 EnsemblBacteria AAC77236 http://www.ensemblgenomes.org/id/AAC77236 EnsemblBacteria AAC77236 http://www.ensemblgenomes.org/id/AAC77236 EnsemblBacteria BAE78274 http://www.ensemblgenomes.org/id/BAE78274 EnsemblBacteria BAE78274 http://www.ensemblgenomes.org/id/BAE78274 EnsemblBacteria BAE78274 http://www.ensemblgenomes.org/id/BAE78274 EnsemblBacteria b4280 http://www.ensemblgenomes.org/id/b4280 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0055114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 948808 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948808 HOGENOM HOG000244297 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000244297&db=HOGENOM6 InParanoid P39353 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39353 IntAct P39353 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39353* IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR000683 http://www.ebi.ac.uk/interpro/entry/IPR000683 InterPro IPR004104 http://www.ebi.ac.uk/interpro/entry/IPR004104 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 KEGG_Gene ecj:JW5769 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5769 KEGG_Gene eco:b4280 http://www.genome.jp/dbget-bin/www_bget?eco:b4280 MINT MINT-1283412 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1283412 OMA RFAVLEW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RFAVLEW PSORT swissprot:YJHC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJHC_ECOLI PSORT-B swissprot:YJHC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJHC_ECOLI PSORT2 swissprot:YJHC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJHC_ECOLI Pfam PF01408 http://pfam.xfam.org/family/PF01408 Pfam PF02894 http://pfam.xfam.org/family/PF02894 Phobius swissprot:YJHC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJHC_ECOLI PhylomeDB P39353 http://phylomedb.org/?seqid=P39353 ProteinModelPortal P39353 http://www.proteinmodelportal.org/query/uniprot/P39353 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418700 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418700 RefSeq WP_000611568 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000611568 STRING 511145.b4280 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4280&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB YJHC_ECOLI http://www.uniprot.org/uniprot/YJHC_ECOLI UniProtKB-AC P39353 http://www.uniprot.org/uniprot/P39353 charge swissprot:YJHC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJHC_ECOLI eggNOG COG0673 http://eggnogapi.embl.de/nog_data/html/tree/COG0673 eggNOG ENOG4107RJ5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107RJ5 epestfind swissprot:YJHC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJHC_ECOLI garnier swissprot:YJHC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJHC_ECOLI helixturnhelix swissprot:YJHC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJHC_ECOLI hmoment swissprot:YJHC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJHC_ECOLI iep swissprot:YJHC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJHC_ECOLI inforesidue swissprot:YJHC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJHC_ECOLI octanol swissprot:YJHC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJHC_ECOLI pepcoil swissprot:YJHC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJHC_ECOLI pepdigest swissprot:YJHC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJHC_ECOLI pepinfo swissprot:YJHC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJHC_ECOLI pepnet swissprot:YJHC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJHC_ECOLI pepstats swissprot:YJHC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJHC_ECOLI pepwheel swissprot:YJHC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJHC_ECOLI pepwindow swissprot:YJHC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJHC_ECOLI sigcleave swissprot:YJHC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJHC_ECOLI ## Database ID URL or Descriptions # BioGrid 4259435 10 # EcoGene EG12820 yhcN # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_process GO:0044011 single-species biofilm formation on inanimate substrate; IMP:EcoCyc. # GO_process GO:0070301 cellular response to hydrogen peroxide; IMP:EcoCyc. # GO_process GO:0071468 cellular response to acidic pH; IEP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # Gene3D 3.30.1660.10 -; 1. # InterPro IPR010854 DUF1471 # InterPro IPR025543 Dodecin-like # Organism YHCN_ECOLI Escherichia coli (strain K12) # PATRIC 32121902 VBIEscCol129921_3335 # Pfam PF07338 DUF1471 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHCN_ECOLI Uncharacterized protein YhcN # RefSeq NP_417705 NC_000913.3 # RefSeq WP_000695690 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA58040.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the BhsA/McbA family. {ECO 0000305}. # SUBCELLULAR LOCATION YHCN_ECOLI Periplasm {ECO 0000305}. # SUPFAM SSF159871 SSF159871 # eggNOG ENOG4105RID Bacteria # eggNOG ENOG4111Z93 LUCA BLAST swissprot:YHCN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHCN_ECOLI BioCyc ECOL316407:JW5540-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5540-MONOMER BioCyc EcoCyc:G7683-MONOMER http://biocyc.org/getid?id=EcoCyc:G7683-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2671 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2671 EcoGene EG12820 http://www.ecogene.org/geneInfo.php?eg_id=EG12820 EnsemblBacteria AAC76270 http://www.ensemblgenomes.org/id/AAC76270 EnsemblBacteria AAC76270 http://www.ensemblgenomes.org/id/AAC76270 EnsemblBacteria BAE77281 http://www.ensemblgenomes.org/id/BAE77281 EnsemblBacteria BAE77281 http://www.ensemblgenomes.org/id/BAE77281 EnsemblBacteria BAE77281 http://www.ensemblgenomes.org/id/BAE77281 EnsemblBacteria b3238 http://www.ensemblgenomes.org/id/b3238 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_process GO:0044011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044011 GO_process GO:0070301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070301 GO_process GO:0071468 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071468 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.30.1660.10 http://www.cathdb.info/version/latest/superfamily/3.30.1660.10 GeneID 947835 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947835 HOGENOM HOG000117400 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117400&db=HOGENOM6 InterPro IPR010854 http://www.ebi.ac.uk/interpro/entry/IPR010854 InterPro IPR025543 http://www.ebi.ac.uk/interpro/entry/IPR025543 KEGG_Gene ecj:JW5540 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5540 KEGG_Gene eco:b3238 http://www.genome.jp/dbget-bin/www_bget?eco:b3238 OMA NGNYHAT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NGNYHAT PSORT swissprot:YHCN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHCN_ECOLI PSORT-B swissprot:YHCN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHCN_ECOLI PSORT2 swissprot:YHCN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHCN_ECOLI Pfam PF07338 http://pfam.xfam.org/family/PF07338 Phobius swissprot:YHCN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHCN_ECOLI ProteinModelPortal P64614 http://www.proteinmodelportal.org/query/uniprot/P64614 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417705 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417705 RefSeq WP_000695690 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000695690 SMR P64614 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P64614 STRING 511145.b3238 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3238&targetmode=cogs SUPFAM SSF159871 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF159871 UniProtKB YHCN_ECOLI http://www.uniprot.org/uniprot/YHCN_ECOLI UniProtKB-AC P64614 http://www.uniprot.org/uniprot/P64614 charge swissprot:YHCN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHCN_ECOLI eggNOG ENOG4105RID http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105RID eggNOG ENOG4111Z93 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111Z93 epestfind swissprot:YHCN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHCN_ECOLI garnier swissprot:YHCN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHCN_ECOLI helixturnhelix swissprot:YHCN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHCN_ECOLI hmoment swissprot:YHCN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHCN_ECOLI iep swissprot:YHCN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHCN_ECOLI inforesidue swissprot:YHCN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHCN_ECOLI octanol swissprot:YHCN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHCN_ECOLI pepcoil swissprot:YHCN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHCN_ECOLI pepdigest swissprot:YHCN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHCN_ECOLI pepinfo swissprot:YHCN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHCN_ECOLI pepnet swissprot:YHCN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHCN_ECOLI pepstats swissprot:YHCN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHCN_ECOLI pepwheel swissprot:YHCN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHCN_ECOLI pepwindow swissprot:YHCN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHCN_ECOLI sigcleave swissprot:YHCN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHCN_ECOLI ## Database ID URL or Descriptions # AltName PGM_ECOLI Glucose phosphomutase # BIOPHYSICOCHEMICAL PROPERTIES PGM_ECOLI Kinetic parameters KM=50 uM for D-glucose-1-phosphate {ECO 0000269|PubMed 14216423}; pH dependence Optimum pH is 9. {ECO 0000269|PubMed 14216423}; # BioGrid 4261910 16 # CATALYTIC ACTIVITY Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate. {ECO:0000269|PubMed 14216423}. # CDD cd05801 PGM_like3 # COFACTOR PGM_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 14216423}; Note=Binds 1 Mg(2+) ion per subunit. {ECO 0000269|PubMed 14216423}; # EcoGene EG12144 pgm # FUNCTION PGM_ECOLI This enzyme participates in both the breakdown and synthesis of glucose. {ECO 0000269|PubMed 14216423}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IEA:InterPro. # GO_function GO:0004614 phosphoglucomutase activity; IDA:EcoCyc. # GO_process GO:0005978 glycogen biosynthetic process; IBA:GO_Central. # GO_process GO:0006006 glucose metabolic process; IBA:GO_Central. # GO_process GO:0019388 galactose catabolic process; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.30.310.50 -; 1. # Gene3D 3.40.120.10 -; 3. # IntAct P36938 7 # InterPro IPR005843 A-D-PHexomutase_C # InterPro IPR005844 A-D-PHexomutase_a/b/a-I # InterPro IPR005845 A-D-PHexomutase_a/b/a-II # InterPro IPR005846 A-D-PHexomutase_a/b/a-III # InterPro IPR005852 PGlcMutase_a-D-Glc-sp # InterPro IPR016055 A-D-PHexomutase_a/b/a-I/II/III # InterPro IPR016066 A-D-PHexomutase_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00010 Glycolysis / Gluconeogenesis # KEGG_Pathway ko00030 Pentose phosphate pathway # KEGG_Pathway ko00052 Galactose metabolism # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00500 Starch and sucrose metabolism # KEGG_Pathway ko00520 Amino sugar and nucleotide sugar metabolism # KEGG_Pathway ko00521 Streptomycin biosynthesis # Organism PGM_ECOLI Escherichia coli (strain K12) # PATRIC 32116569 VBIEscCol129921_0717 # PIR G64803 G64803 # PROSITE PS00710 PGM_PMM # Pfam PF00408 PGM_PMM_IV # Pfam PF02878 PGM_PMM_I # Pfam PF02879 PGM_PMM_II # Pfam PF02880 PGM_PMM_III # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PGM_ECOLI Phosphoglucomutase # RefSeq NP_415214 NC_000913.3 # RefSeq WP_001297249 NZ_LN832404.1 # SIMILARITY Belongs to the phosphohexose mutase family. {ECO 0000305}. # SUBCELLULAR LOCATION PGM_ECOLI Cytoplasm {ECO 0000269|PubMed 21778229}. # SUPFAM SSF53738 SSF53738; 3 # SUPFAM SSF55957 SSF55957 # TIGRFAMs TIGR01132 pgm # eggNOG COG0033 LUCA # eggNOG ENOG4107QIX Bacteria BLAST swissprot:PGM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PGM_ECOLI BioCyc ECOL316407:JW0675-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0675-MONOMER BioCyc EcoCyc:PHOSPHOGLUCMUT-MONOMER http://biocyc.org/getid?id=EcoCyc:PHOSPHOGLUCMUT-MONOMER BioCyc MetaCyc:PHOSPHOGLUCMUT-MONOMER http://biocyc.org/getid?id=MetaCyc:PHOSPHOGLUCMUT-MONOMER COG COG0033 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0033 DIP DIP-10472N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10472N DOI 10.1016/0092-8674(94)90156-2 http://dx.doi.org/10.1016/0092-8674(94)90156-2 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M111.245696 http://dx.doi.org/10.1074/jbc.M111.245696 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.4.2.2 http://www.genome.jp/dbget-bin/www_bget?EC:5.4.2.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U07651 http://www.ebi.ac.uk/ena/data/view/U07651 EMBL U08369 http://www.ebi.ac.uk/ena/data/view/U08369 ENZYME 5.4.2.2 http://enzyme.expasy.org/EC/5.4.2.2 EchoBASE EB2065 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2065 EcoGene EG12144 http://www.ecogene.org/geneInfo.php?eg_id=EG12144 EnsemblBacteria AAC73782 http://www.ensemblgenomes.org/id/AAC73782 EnsemblBacteria AAC73782 http://www.ensemblgenomes.org/id/AAC73782 EnsemblBacteria BAA35337 http://www.ensemblgenomes.org/id/BAA35337 EnsemblBacteria BAA35337 http://www.ensemblgenomes.org/id/BAA35337 EnsemblBacteria BAA35337 http://www.ensemblgenomes.org/id/BAA35337 EnsemblBacteria b0688 http://www.ensemblgenomes.org/id/b0688 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0004614 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004614 GO_process GO:0005978 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005978 GO_process GO:0006006 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006006 GO_process GO:0019388 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019388 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.30.310.50 http://www.cathdb.info/version/latest/superfamily/3.30.310.50 Gene3D 3.40.120.10 http://www.cathdb.info/version/latest/superfamily/3.40.120.10 GeneID 945271 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945271 HOGENOM HOG000268677 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000268677&db=HOGENOM6 InParanoid P36938 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P36938 IntAct P36938 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P36938* IntEnz 5.4.2.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.4.2.2 InterPro IPR005843 http://www.ebi.ac.uk/interpro/entry/IPR005843 InterPro IPR005844 http://www.ebi.ac.uk/interpro/entry/IPR005844 InterPro IPR005845 http://www.ebi.ac.uk/interpro/entry/IPR005845 InterPro IPR005846 http://www.ebi.ac.uk/interpro/entry/IPR005846 InterPro IPR005852 http://www.ebi.ac.uk/interpro/entry/IPR005852 InterPro IPR016055 http://www.ebi.ac.uk/interpro/entry/IPR016055 InterPro IPR016066 http://www.ebi.ac.uk/interpro/entry/IPR016066 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0675 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0675 KEGG_Gene eco:b0688 http://www.genome.jp/dbget-bin/www_bget?eco:b0688 KEGG_Orthology KO:K01835 http://www.genome.jp/dbget-bin/www_bget?KO:K01835 KEGG_Pathway ko00010 http://www.genome.jp/kegg-bin/show_pathway?ko00010 KEGG_Pathway ko00030 http://www.genome.jp/kegg-bin/show_pathway?ko00030 KEGG_Pathway ko00052 http://www.genome.jp/kegg-bin/show_pathway?ko00052 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00500 http://www.genome.jp/kegg-bin/show_pathway?ko00500 KEGG_Pathway ko00520 http://www.genome.jp/kegg-bin/show_pathway?ko00520 KEGG_Pathway ko00521 http://www.genome.jp/kegg-bin/show_pathway?ko00521 KEGG_Reaction rn:R00959 http://www.genome.jp/dbget-bin/www_bget?rn:R00959 KEGG_Reaction rn:R01057 http://www.genome.jp/dbget-bin/www_bget?rn:R01057 KEGG_Reaction rn:R08639 http://www.genome.jp/dbget-bin/www_bget?rn:R08639 MINT MINT-1240111 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1240111 OMA YYARHDY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YYARHDY PROSITE PS00710 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00710 PSORT swissprot:PGM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PGM_ECOLI PSORT-B swissprot:PGM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PGM_ECOLI PSORT2 swissprot:PGM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PGM_ECOLI Pfam PF00408 http://pfam.xfam.org/family/PF00408 Pfam PF02878 http://pfam.xfam.org/family/PF02878 Pfam PF02879 http://pfam.xfam.org/family/PF02879 Pfam PF02880 http://pfam.xfam.org/family/PF02880 Phobius swissprot:PGM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PGM_ECOLI PhylomeDB P36938 http://phylomedb.org/?seqid=P36938 ProteinModelPortal P36938 http://www.proteinmodelportal.org/query/uniprot/P36938 PubMed 14216423 http://www.ncbi.nlm.nih.gov/pubmed/14216423 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21778229 http://www.ncbi.nlm.nih.gov/pubmed/21778229 PubMed 8011018 http://www.ncbi.nlm.nih.gov/pubmed/8011018 PubMed 8083177 http://www.ncbi.nlm.nih.gov/pubmed/8083177 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415214 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415214 RefSeq WP_001297249 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001297249 SMR P36938 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P36938 STRING 511145.b0688 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0688&targetmode=cogs STRING COG0033 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0033&targetmode=cogs SUPFAM SSF53738 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53738 SUPFAM SSF55957 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55957 TIGRFAMs TIGR01132 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01132 UniProtKB PGM_ECOLI http://www.uniprot.org/uniprot/PGM_ECOLI UniProtKB-AC P36938 http://www.uniprot.org/uniprot/P36938 charge swissprot:PGM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PGM_ECOLI eggNOG COG0033 http://eggnogapi.embl.de/nog_data/html/tree/COG0033 eggNOG ENOG4107QIX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QIX epestfind swissprot:PGM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PGM_ECOLI garnier swissprot:PGM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PGM_ECOLI helixturnhelix swissprot:PGM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PGM_ECOLI hmoment swissprot:PGM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PGM_ECOLI iep swissprot:PGM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PGM_ECOLI inforesidue swissprot:PGM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PGM_ECOLI octanol swissprot:PGM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PGM_ECOLI pepcoil swissprot:PGM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PGM_ECOLI pepdigest swissprot:PGM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PGM_ECOLI pepinfo swissprot:PGM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PGM_ECOLI pepnet swissprot:PGM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PGM_ECOLI pepstats swissprot:PGM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PGM_ECOLI pepwheel swissprot:PGM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PGM_ECOLI pepwindow swissprot:PGM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PGM_ECOLI sigcleave swissprot:PGM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PGM_ECOLI ## Database ID URL or Descriptions # BioGrid 4261201 11 # DISRUPTION PHENOTYPE Simultaneous disruption of erfK, ybiS, ycfS and ynhG leads to loss of covalent anchoring of the major outer membrane lipoprotein (Lpp) to the peptidoglycan. Complementation with ybiS restores most of this anchoring. {ECO:0000269|PubMed 18456808}. # EcoGene EG13324 ybiS # FUNCTION YBIS_ECOLI Responsible, at least in part, for anchoring of the major outer membrane lipoprotein (Lpp, also known as the Braun lipoprotein) to the peptidoglycan via a meso-diaminopimelyl-L-Lys- bond on the terminal residue of Lpp. Can be oxidized in vivo, its reduction depends preferentially on DsbG, although DsbC is able to partially replace DsbG. {ECO 0000269|PubMed 18456808}. # GO_component GO:0042597 periplasmic space; IDA:EcoCyc. # GO_function GO:0016755 transferase activity, transferring amino-acyl groups; IMP:EcoCyc. # GO_function GO:0016757 transferase activity, transferring glycosyl groups; IEA:UniProtKB-KW. # GO_function GO:0016807 cysteine-type carboxypeptidase activity; IMP:EcoCyc. # GO_function GO:0071972 peptidoglycan L,D-transpeptidase activity; IMP:EcoCyc. # GO_process GO:0008360 regulation of cell shape; IEA:UniProtKB-KW. # GO_process GO:0018104 peptidoglycan-protein cross-linking; IMP:EcoCyc. # GO_process GO:0043164 Gram-negative-bacterium-type cell wall biogenesis; IMP:EcoCyc. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0071554 cell wall organization or biogenesis # IntAct P0AAX8 3 # InterPro IPR005490 LD_TPept_cat_dom # KEGG_Brite ko01002 Peptidases # Organism YBIS_ECOLI Escherichia coli (strain K12) # PATHWAY YBIS_ECOLI Cell wall biogenesis; peptidoglycan biosynthesis. # PATRIC 32116841 VBIEscCol129921_0846 # PIR C64819 C64819 # PTM YBIS_ECOLI In vivo a sulfenic acid can be formed on Cys-210, which probably inactivates the protein. This disulfide is subsequently reduced by DsbG and DsbC. # Pfam PF03734 YkuD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBIS_ECOLI Probable L,D-transpeptidase YbiS # RefSeq NP_415340 NC_000913.3 # RefSeq WP_001056384 NZ_LN832404.1 # SIMILARITY Belongs to the YkuD family. {ECO 0000305}. # SUBCELLULAR LOCATION YBIS_ECOLI Periplasm. # SUBUNIT Interacts with DsbG. {ECO:0000269|PubMed 19965429}. # eggNOG COG1376 LUCA # eggNOG ENOG4107N1Q Bacteria BLAST swissprot:YBIS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBIS_ECOLI BioCyc ECOL316407:JW0803-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0803-MONOMER BioCyc EcoCyc:G6422-MONOMER http://biocyc.org/getid?id=EcoCyc:G6422-MONOMER BioCyc MetaCyc:G6422-MONOMER http://biocyc.org/getid?id=MetaCyc:G6422-MONOMER COG COG1376 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1376 DIP DIP-48069N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48069N DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1179557 http://dx.doi.org/10.1126/science.1179557 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00025-08 http://dx.doi.org/10.1128/JB.00025-08 EC_number EC:2.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:2.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.-.-.- http://enzyme.expasy.org/EC/2.-.-.- EchoBASE EB3108 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3108 EcoGene EG13324 http://www.ecogene.org/geneInfo.php?eg_id=EG13324 EnsemblBacteria AAC73906 http://www.ensemblgenomes.org/id/AAC73906 EnsemblBacteria AAC73906 http://www.ensemblgenomes.org/id/AAC73906 EnsemblBacteria BAA35500 http://www.ensemblgenomes.org/id/BAA35500 EnsemblBacteria BAA35500 http://www.ensemblgenomes.org/id/BAA35500 EnsemblBacteria BAA35500 http://www.ensemblgenomes.org/id/BAA35500 EnsemblBacteria b0819 http://www.ensemblgenomes.org/id/b0819 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0016755 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016755 GO_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GO_function GO:0016807 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016807 GO_function GO:0071972 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071972 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0018104 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018104 GO_process GO:0043164 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043164 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 GeneID 945441 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945441 HOGENOM HOG000274378 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000274378&db=HOGENOM6 InParanoid P0AAX8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAX8 IntAct P0AAX8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAX8* IntEnz 2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2 InterPro IPR005490 http://www.ebi.ac.uk/interpro/entry/IPR005490 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW0803 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0803 KEGG_Gene eco:b0819 http://www.genome.jp/dbget-bin/www_bget?eco:b0819 KEGG_Orthology KO:K16291 http://www.genome.jp/dbget-bin/www_bget?KO:K16291 OMA QNRSGMP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QNRSGMP PSORT swissprot:YBIS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBIS_ECOLI PSORT-B swissprot:YBIS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBIS_ECOLI PSORT2 swissprot:YBIS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBIS_ECOLI Pfam PF03734 http://pfam.xfam.org/family/PF03734 Phobius swissprot:YBIS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBIS_ECOLI PhylomeDB P0AAX8 http://phylomedb.org/?seqid=P0AAX8 ProteinModelPortal P0AAX8 http://www.proteinmodelportal.org/query/uniprot/P0AAX8 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18456808 http://www.ncbi.nlm.nih.gov/pubmed/18456808 PubMed 19965429 http://www.ncbi.nlm.nih.gov/pubmed/19965429 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_415340 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415340 RefSeq WP_001056384 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001056384 SMR P0AAX8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAX8 STRING 511145.b0819 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0819&targetmode=cogs STRING COG1376 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1376&targetmode=cogs UniProtKB YBIS_ECOLI http://www.uniprot.org/uniprot/YBIS_ECOLI UniProtKB-AC P0AAX8 http://www.uniprot.org/uniprot/P0AAX8 charge swissprot:YBIS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBIS_ECOLI eggNOG COG1376 http://eggnogapi.embl.de/nog_data/html/tree/COG1376 eggNOG ENOG4107N1Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107N1Q epestfind swissprot:YBIS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBIS_ECOLI garnier swissprot:YBIS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBIS_ECOLI helixturnhelix swissprot:YBIS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBIS_ECOLI hmoment swissprot:YBIS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBIS_ECOLI iep swissprot:YBIS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBIS_ECOLI inforesidue swissprot:YBIS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBIS_ECOLI octanol swissprot:YBIS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBIS_ECOLI pepcoil swissprot:YBIS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBIS_ECOLI pepdigest swissprot:YBIS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBIS_ECOLI pepinfo swissprot:YBIS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBIS_ECOLI pepnet swissprot:YBIS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBIS_ECOLI pepstats swissprot:YBIS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBIS_ECOLI pepwheel swissprot:YBIS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBIS_ECOLI pepwindow swissprot:YBIS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBIS_ECOLI sigcleave swissprot:YBIS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBIS_ECOLI ## Database ID URL or Descriptions # AltName ILVN_ECOLI Acetohydroxy-acid synthase I small subunit # BioGrid 4262585 7 # CATALYTIC ACTIVITY ILVN_ECOLI 2 pyruvate = 2-acetolactate + CO(2). # EcoGene EG10502 ilvN # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_component GO:0005948 acetolactate synthase complex; IDA:EcoCyc. # GO_function GO:0003984 acetolactate synthase activity; IDA:EcoCyc. # GO_function GO:0016597 amino acid binding; IEA:InterPro. # GO_process GO:0009097 isoleucine biosynthetic process; IDA:EcoCyc. # GO_process GO:0009099 valine biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # IntAct P0ADF8 6 # InterPro IPR002912 ACT_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00290 Valine, leucine and isoleucine biosynthesis # KEGG_Pathway ko00650 Butanoate metabolism # KEGG_Pathway ko00660 C5-Branched dibasic acid metabolism # KEGG_Pathway ko00770 Pantothenate and CoA biosynthesis # MISCELLANEOUS E.coli contains genes for 3 AHAS isozymes ilvBN, ilvGM and ilvIH. # Organism ILVN_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-isoleucine biosynthesis; L- isoleucine from 2-oxobutanoate step 1/4. # PATHWAY Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate step 1/4. # PATRIC 32122833 VBIEscCol129921_3792 # PDB 2LVW NMR; -; A/B=1-96 # PIR G65168 YCEC1S # PROSITE PS51671 ACT # Pfam PF01842 ACT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ILVN_ECOLI Acetolactate synthase isozyme 1 small subunit # RefSeq NP_418126 NC_000913.3 # RefSeq WP_001181706 NZ_LN832404.1 # SIMILARITY Belongs to the acetolactate synthase small subunit family. {ECO 0000305}. # SIMILARITY Contains 1 ACT domain. {ECO:0000255|PROSITE- ProRule PRU01007}. # SUBUNIT ILVN_ECOLI Dimer of large and small chains. # UniPathway UPA00047 UER00055 # UniPathway UPA00049 UER00059 # eggNOG COG0440 LUCA # eggNOG ENOG4105M71 Bacteria BLAST swissprot:ILVN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ILVN_ECOLI BioCyc ECOL316407:JW3645-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3645-MONOMER BioCyc EcoCyc:SMALLILVN-MONOMER http://biocyc.org/getid?id=EcoCyc:SMALLILVN-MONOMER BioCyc MetaCyc:SMALLILVN-MONOMER http://biocyc.org/getid?id=MetaCyc:SMALLILVN-MONOMER COG COG0440 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0440 DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/13.11.3979 http://dx.doi.org/10.1093/nar/13.11.3979 DOI 10.1093/nar/13.11.3995 http://dx.doi.org/10.1093/nar/13.11.3995 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.2.1.6 http://www.genome.jp/dbget-bin/www_bget?EC:2.2.1.6 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M17102 http://www.ebi.ac.uk/ena/data/view/M17102 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X02541 http://www.ebi.ac.uk/ena/data/view/X02541 ENZYME 2.2.1.6 http://enzyme.expasy.org/EC/2.2.1.6 EchoBASE EB0497 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0497 EcoGene EG10502 http://www.ecogene.org/geneInfo.php?eg_id=EG10502 EnsemblBacteria AAC76693 http://www.ensemblgenomes.org/id/AAC76693 EnsemblBacteria AAC76693 http://www.ensemblgenomes.org/id/AAC76693 EnsemblBacteria BAE77623 http://www.ensemblgenomes.org/id/BAE77623 EnsemblBacteria BAE77623 http://www.ensemblgenomes.org/id/BAE77623 EnsemblBacteria BAE77623 http://www.ensemblgenomes.org/id/BAE77623 EnsemblBacteria b3670 http://www.ensemblgenomes.org/id/b3670 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005948 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005948 GO_function GO:0003984 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003984 GO_function GO:0016597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016597 GO_process GO:0009097 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009097 GO_process GO:0009099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009099 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 948183 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948183 HOGENOM HOG000126293 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126293&db=HOGENOM6 IntAct P0ADF8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADF8* IntEnz 2.2.1.6 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.2.1.6 InterPro IPR002912 http://www.ebi.ac.uk/interpro/entry/IPR002912 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3645 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3645 KEGG_Gene eco:b3670 http://www.genome.jp/dbget-bin/www_bget?eco:b3670 KEGG_Orthology KO:K01653 http://www.genome.jp/dbget-bin/www_bget?KO:K01653 KEGG_Pathway ko00290 http://www.genome.jp/kegg-bin/show_pathway?ko00290 KEGG_Pathway ko00650 http://www.genome.jp/kegg-bin/show_pathway?ko00650 KEGG_Pathway ko00660 http://www.genome.jp/kegg-bin/show_pathway?ko00660 KEGG_Pathway ko00770 http://www.genome.jp/kegg-bin/show_pathway?ko00770 KEGG_Reaction rn:R00006 http://www.genome.jp/dbget-bin/www_bget?rn:R00006 KEGG_Reaction rn:R00014 http://www.genome.jp/dbget-bin/www_bget?rn:R00014 KEGG_Reaction rn:R00226 http://www.genome.jp/dbget-bin/www_bget?rn:R00226 KEGG_Reaction rn:R03050 http://www.genome.jp/dbget-bin/www_bget?rn:R03050 KEGG_Reaction rn:R04672 http://www.genome.jp/dbget-bin/www_bget?rn:R04672 KEGG_Reaction rn:R04673 http://www.genome.jp/dbget-bin/www_bget?rn:R04673 OMA SHENVIL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SHENVIL PDB 2LVW http://www.ebi.ac.uk/pdbe-srv/view/entry/2LVW PDBsum 2LVW http://www.ebi.ac.uk/pdbsum/2LVW PROSITE PS51671 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51671 PSORT swissprot:ILVN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ILVN_ECOLI PSORT-B swissprot:ILVN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ILVN_ECOLI PSORT2 swissprot:ILVN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ILVN_ECOLI Pfam PF01842 http://pfam.xfam.org/family/PF01842 Phobius swissprot:ILVN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ILVN_ECOLI PhylomeDB P0ADF8 http://phylomedb.org/?seqid=P0ADF8 ProteinModelPortal P0ADF8 http://www.proteinmodelportal.org/query/uniprot/P0ADF8 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2989781 http://www.ncbi.nlm.nih.gov/pubmed/2989781 PubMed 2989782 http://www.ncbi.nlm.nih.gov/pubmed/2989782 PubMed 3301805 http://www.ncbi.nlm.nih.gov/pubmed/3301805 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_418126 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418126 RefSeq WP_001181706 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001181706 SMR P0ADF8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADF8 STRING 511145.b3670 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3670&targetmode=cogs STRING COG0440 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0440&targetmode=cogs UniProtKB ILVN_ECOLI http://www.uniprot.org/uniprot/ILVN_ECOLI UniProtKB-AC P0ADF8 http://www.uniprot.org/uniprot/P0ADF8 charge swissprot:ILVN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ILVN_ECOLI eggNOG COG0440 http://eggnogapi.embl.de/nog_data/html/tree/COG0440 eggNOG ENOG4105M71 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105M71 epestfind swissprot:ILVN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ILVN_ECOLI garnier swissprot:ILVN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ILVN_ECOLI helixturnhelix swissprot:ILVN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ILVN_ECOLI hmoment swissprot:ILVN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ILVN_ECOLI iep swissprot:ILVN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ILVN_ECOLI inforesidue swissprot:ILVN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ILVN_ECOLI octanol swissprot:ILVN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ILVN_ECOLI pepcoil swissprot:ILVN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ILVN_ECOLI pepdigest swissprot:ILVN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ILVN_ECOLI pepinfo swissprot:ILVN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ILVN_ECOLI pepnet swissprot:ILVN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ILVN_ECOLI pepstats swissprot:ILVN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ILVN_ECOLI pepwheel swissprot:ILVN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ILVN_ECOLI pepwindow swissprot:ILVN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ILVN_ECOLI sigcleave swissprot:ILVN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ILVN_ECOLI ## Database ID URL or Descriptions # AltName DPIA_ECOLI Destabilizer of plasmid inheritance # BioGrid 4263364 6 # EcoGene EG13544 dpiA # FUNCTION DPIA_ECOLI Member of the two-component regulatory system DpiA/DpiB, which is essential for expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. Could be involved in response to both the presence of citrate and external redox conditions. Regulates the transcription of citCDEFXGT, dpiAB, mdh and exuT. Binds specifically to the dpiB-citC intergenic region. {ECO 0000269|PubMed 18997424, ECO 0000269|PubMed 19202292}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0000156 phosphorelay response regulator activity; IDA:EcoCyc. # GO_function GO:0001071 nucleic acid binding transcription factor activity; IEA:InterPro. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_process GO:0000160 phosphorelay signal transduction system; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IMP:EcoCyc. # GO_process GO:0009605 response to external stimulus; IEA:InterPro. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004871 signal transducer activity # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # INTERACTION DPIA_ECOLI P76079 paaC; NbExp=4; IntAct=EBI-1119284, EBI-1131666; P39409 yjjW; NbExp=2; IntAct=EBI-1119284, EBI-9132384; # IntAct P0AEF4 15 # InterPro IPR001789 Sig_transdc_resp-reg_receiver # InterPro IPR011006 CheY-like_superfamily # InterPro IPR024187 Sig_transdc_resp-reg_cit/mal # InterPro IPR028141 Transcriptional_reg_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02022 M00486 CitA-CitB (citrate fermentation) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # Organism DPIA_ECOLI Escherichia coli (strain K12) # PATRIC 32116420 VBIEscCol129921_0650 # PIR B64796 B64796 # PIRSF PIRSF006171 RR_citrat_malat # PROSITE PS50110 RESPONSE_REGULATORY # PTM DPIA_ECOLI Phosphorylated and activated by DpiB. {ECO 0000269|PubMed 19202292}. # Pfam PF00072 Response_reg # Pfam PF12431 CitT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DPIA_ECOLI Transcriptional regulatory protein DpiA # RefSeq NP_415153 NC_000913.3 # RefSeq WP_000126500 NZ_LN832404.1 # SIMILARITY Contains 1 response regulatory domain. {ECO:0000255|PROSITE-ProRule PRU00169}. # SMART SM00448 REC # SUBCELLULAR LOCATION DPIA_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF52172 SSF52172 # eggNOG COG4565 LUCA # eggNOG ENOG4106YYS Bacteria BLAST swissprot:DPIA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DPIA_ECOLI BioCyc ECOL316407:JW0612-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0612-MONOMER BioCyc EcoCyc:G6346-MONOMER http://biocyc.org/getid?id=EcoCyc:G6346-MONOMER COG COG4565 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4565 DIP DIP-47831N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47831N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1998.00895.x http://dx.doi.org/10.1046/j.1365-2958.1998.00895.x DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1271/bbb.80301 http://dx.doi.org/10.1271/bbb.80301 DOI 10.1271/bbb.80586 http://dx.doi.org/10.1271/bbb.80586 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U46667 http://www.ebi.ac.uk/ena/data/view/U46667 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB3314 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3314 EcoGene EG13544 http://www.ecogene.org/geneInfo.php?eg_id=EG13544 EnsemblBacteria AAC73721 http://www.ensemblgenomes.org/id/AAC73721 EnsemblBacteria AAC73721 http://www.ensemblgenomes.org/id/AAC73721 EnsemblBacteria BAA35256 http://www.ensemblgenomes.org/id/BAA35256 EnsemblBacteria BAA35256 http://www.ensemblgenomes.org/id/BAA35256 EnsemblBacteria BAA35256 http://www.ensemblgenomes.org/id/BAA35256 EnsemblBacteria b0620 http://www.ensemblgenomes.org/id/b0620 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000156 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000156 GO_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0009605 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009605 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 947008 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947008 HOGENOM HOG000034816 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000034816&db=HOGENOM6 InParanoid P0AEF4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEF4 IntAct P0AEF4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEF4* InterPro IPR001789 http://www.ebi.ac.uk/interpro/entry/IPR001789 InterPro IPR011006 http://www.ebi.ac.uk/interpro/entry/IPR011006 InterPro IPR024187 http://www.ebi.ac.uk/interpro/entry/IPR024187 InterPro IPR028141 http://www.ebi.ac.uk/interpro/entry/IPR028141 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW0612 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0612 KEGG_Gene eco:b0620 http://www.genome.jp/dbget-bin/www_bget?eco:b0620 KEGG_Orthology KO:K07702 http://www.genome.jp/dbget-bin/www_bget?KO:K07702 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 MINT MINT-1286196 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1286196 OMA ECIVITA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ECIVITA PROSITE PS50110 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50110 PSORT swissprot:DPIA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DPIA_ECOLI PSORT-B swissprot:DPIA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DPIA_ECOLI PSORT2 swissprot:DPIA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DPIA_ECOLI Pfam PF00072 http://pfam.xfam.org/family/PF00072 Pfam PF12431 http://pfam.xfam.org/family/PF12431 Phobius swissprot:DPIA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DPIA_ECOLI PhylomeDB P0AEF4 http://phylomedb.org/?seqid=P0AEF4 ProteinModelPortal P0AEF4 http://www.proteinmodelportal.org/query/uniprot/P0AEF4 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18997424 http://www.ncbi.nlm.nih.gov/pubmed/18997424 PubMed 19202292 http://www.ncbi.nlm.nih.gov/pubmed/19202292 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9701802 http://www.ncbi.nlm.nih.gov/pubmed/9701802 RefSeq NP_415153 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415153 RefSeq WP_000126500 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000126500 SMART SM00448 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00448 SMR P0AEF4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEF4 STRING 511145.b0620 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0620&targetmode=cogs STRING COG4565 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4565&targetmode=cogs SUPFAM SSF52172 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52172 UniProtKB DPIA_ECOLI http://www.uniprot.org/uniprot/DPIA_ECOLI UniProtKB-AC P0AEF4 http://www.uniprot.org/uniprot/P0AEF4 charge swissprot:DPIA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DPIA_ECOLI eggNOG COG4565 http://eggnogapi.embl.de/nog_data/html/tree/COG4565 eggNOG ENOG4106YYS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106YYS epestfind swissprot:DPIA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DPIA_ECOLI garnier swissprot:DPIA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DPIA_ECOLI helixturnhelix swissprot:DPIA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DPIA_ECOLI hmoment swissprot:DPIA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DPIA_ECOLI iep swissprot:DPIA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DPIA_ECOLI inforesidue swissprot:DPIA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DPIA_ECOLI octanol swissprot:DPIA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DPIA_ECOLI pepcoil swissprot:DPIA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DPIA_ECOLI pepdigest swissprot:DPIA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DPIA_ECOLI pepinfo swissprot:DPIA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DPIA_ECOLI pepnet swissprot:DPIA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DPIA_ECOLI pepstats swissprot:DPIA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DPIA_ECOLI pepwheel swissprot:DPIA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DPIA_ECOLI pepwindow swissprot:DPIA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DPIA_ECOLI sigcleave swissprot:DPIA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DPIA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261541 184 # CDD cd06174 MFS # ENZYME REGULATION Inhibited by CCCP but unaffected by sodium depletion. {ECO:0000269|PubMed 18485005}. # EcoGene EG12232 dtpB # FUNCTION DTPB_ECOLI Proton-dependent permease that transports di- and tripeptides. Has a clear preference for dipeptides and tripeptides composed of L-amino acids, and discriminates dipeptides on the basis of the position of charges within the substrate. {ECO 0000269|PubMed 18485005}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_function DTPB_ECOLI GO 0015333 peptide proton symporter activity; IDA EcoCyc. # GO_function GO:0015078 hydrogen ion transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0042895 antibiotic transporter activity; IMP:EcoCyc. # GO_function GO:0042937 tripeptide transporter activity; IMP:EcoCyc. # GO_function GO:0071916 dipeptide transmembrane transporter activity; IDA:EcoCyc. # GO_process GO:0015031 protein transport; IEA:UniProtKB-KW. # GO_process GO:0035442 dipeptide transmembrane transport; IDA:EcoCyc. # GO_process GO:0035443 tripeptide transmembrane transport; IMP:EcoCyc. # GO_process GO:0042891 antibiotic transport; IMP:EcoCyc. # GO_process GO:1902600 hydrogen ion transmembrane transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # HAMAP MF_01879 PTR2_DtpB_subfam # InterPro IPR000109 POT_fam # InterPro IPR005279 Dipep/tripep_permease # InterPro IPR018456 PTR2_symporter_CS # InterPro IPR020846 MFS_dom # InterPro IPR023778 AA/pep_transptr_DtpB # MISCELLANEOUS DTPB_ECOLI Although DtpB appears to represent a system of lower affinity, there is an obvious redundancy in substrate specificity as compared with DtpA. # Organism DTPB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11654 PTHR11654; 2 # PATRIC 32122442 VBIEscCol129921_3598 # PIR C65147 C65147 # PROSITE PS01022 PTR2_1 # PROSITE PS01023 PTR2_2 # Pfam PF00854 PTR2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DTPB_ECOLI Dipeptide and tripeptide permease B # RefSeq NP_417953 NC_000913.3 # RefSeq WP_001098652 NZ_LN832404.1 # SIMILARITY Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpB subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION DTPB_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF103473 SSF103473; 2 # TCDB 2.A.17.1 the proton-dependent oligopeptide transporter (pot/ptr) family # TIGRFAMs TIGR00924 yjdL_sub1_fam # eggNOG COG3104 LUCA # eggNOG ENOG4105DUX Bacteria BLAST swissprot:DTPB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DTPB_ECOLI BioCyc ECOL316407:JW3463-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3463-MONOMER BioCyc EcoCyc:YHIP-MONOMER http://biocyc.org/getid?id=EcoCyc:YHIP-MONOMER BioCyc MetaCyc:YHIP-MONOMER http://biocyc.org/getid?id=MetaCyc:YHIP-MONOMER COG COG3104 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3104 DIP DIP-12369N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12369N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1111/j.1742-4658.2008.06477.x http://dx.doi.org/10.1111/j.1742-4658.2008.06477.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2144 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2144 EcoGene EG12232 http://www.ecogene.org/geneInfo.php?eg_id=EG12232 EnsemblBacteria AAC76521 http://www.ensemblgenomes.org/id/AAC76521 EnsemblBacteria AAC76521 http://www.ensemblgenomes.org/id/AAC76521 EnsemblBacteria BAE77798 http://www.ensemblgenomes.org/id/BAE77798 EnsemblBacteria BAE77798 http://www.ensemblgenomes.org/id/BAE77798 EnsemblBacteria BAE77798 http://www.ensemblgenomes.org/id/BAE77798 EnsemblBacteria b3496 http://www.ensemblgenomes.org/id/b3496 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015078 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015078 GO_function GO:0015333 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015333 GO_function GO:0042895 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042895 GO_function GO:0042937 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042937 GO_function GO:0071916 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071916 GO_process GO:0015031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031 GO_process GO:0035442 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035442 GO_process GO:0035443 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035443 GO_process GO:0042891 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042891 GO_process GO:1902600 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902600 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 948006 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948006 HAMAP MF_01879 http://hamap.expasy.org/unirule/MF_01879 HOGENOM HOG000243449 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000243449&db=HOGENOM6 InParanoid P36837 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P36837 IntAct P36837 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P36837* InterPro IPR000109 http://www.ebi.ac.uk/interpro/entry/IPR000109 InterPro IPR005279 http://www.ebi.ac.uk/interpro/entry/IPR005279 InterPro IPR018456 http://www.ebi.ac.uk/interpro/entry/IPR018456 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 InterPro IPR023778 http://www.ebi.ac.uk/interpro/entry/IPR023778 KEGG_Gene ecj:JW3463 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3463 KEGG_Gene eco:b3496 http://www.genome.jp/dbget-bin/www_bget?eco:b3496 KEGG_Orthology KO:K03305 http://www.genome.jp/dbget-bin/www_bget?KO:K03305 MINT MINT-1286392 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1286392 OMA FYVLYAQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FYVLYAQ PANTHER PTHR11654 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11654 PROSITE PS01022 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01022 PROSITE PS01023 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01023 PSORT swissprot:DTPB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DTPB_ECOLI PSORT-B swissprot:DTPB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DTPB_ECOLI PSORT2 swissprot:DTPB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DTPB_ECOLI Pfam PF00854 http://pfam.xfam.org/family/PF00854 Phobius swissprot:DTPB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DTPB_ECOLI PhylomeDB P36837 http://phylomedb.org/?seqid=P36837 ProteinModelPortal P36837 http://www.proteinmodelportal.org/query/uniprot/P36837 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18485005 http://www.ncbi.nlm.nih.gov/pubmed/18485005 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417953 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417953 RefSeq WP_001098652 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001098652 STRING 511145.b3496 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3496&targetmode=cogs STRING COG3104 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3104&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.17.1 http://www.tcdb.org/search/result.php?tc=2.A.17.1 TIGRFAMs TIGR00924 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00924 UniProtKB DTPB_ECOLI http://www.uniprot.org/uniprot/DTPB_ECOLI UniProtKB-AC P36837 http://www.uniprot.org/uniprot/P36837 charge swissprot:DTPB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DTPB_ECOLI eggNOG COG3104 http://eggnogapi.embl.de/nog_data/html/tree/COG3104 eggNOG ENOG4105DUX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DUX epestfind swissprot:DTPB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DTPB_ECOLI garnier swissprot:DTPB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DTPB_ECOLI helixturnhelix swissprot:DTPB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DTPB_ECOLI hmoment swissprot:DTPB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DTPB_ECOLI iep swissprot:DTPB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DTPB_ECOLI inforesidue swissprot:DTPB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DTPB_ECOLI octanol swissprot:DTPB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DTPB_ECOLI pepcoil swissprot:DTPB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DTPB_ECOLI pepdigest swissprot:DTPB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DTPB_ECOLI pepinfo swissprot:DTPB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DTPB_ECOLI pepnet swissprot:DTPB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DTPB_ECOLI pepstats swissprot:DTPB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DTPB_ECOLI pepwheel swissprot:DTPB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DTPB_ECOLI pepwindow swissprot:DTPB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DTPB_ECOLI sigcleave swissprot:DTPB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DTPB_ECOLI ## Database ID URL or Descriptions # AltName RLMH_ECOLI 23S rRNA (pseudouridine1915-N3)-methyltransferase # AltName RLMH_ECOLI 23S rRNA m3Psi1915 methyltransferase # AltName RLMH_ECOLI rRNA (pseudouridine-N3-)-methyltransferase RlmH # BRENDA 2.1.1.177 2026 # CATALYTIC ACTIVITY RLMH_ECOLI S-adenosyl-L-methionine + pseudouridine(1915) in 23S rRNA = S-adenosyl-L-homocysteine + N(3)- methylpseudouridine(1915) in 23S rRNA. # EcoGene EG11254 rlmH # FUNCTION RLMH_ECOLI Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA. Specific for fully assembled 70S ribosomes. {ECO 0000269|PubMed 18755835, ECO 0000269|PubMed 18755836}. # GO_component GO:0005737 cytoplasm; IC:UniProtKB. # GO_function GO:0042803 protein homodimerization activity; NAS:UniProtKB. # GO_function GO:0043022 ribosome binding; NAS:UniProtKB. # GO_function GO:0070038 rRNA (pseudouridine-N3-)-methyltransferase activity; IMP:UniProtKB. # GO_process GO:0031167 rRNA methylation; IDA:UniProtKB. # GO_process GO:0070475 rRNA base methylation; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.1280.10 -; 1. # HAMAP MF_00658 23SrRNA_methyltr_H # IntAct P0A8I8 11 # InterPro IPR003742 SPOUT_MeTrfase # InterPro IPR016051 RlmH # InterPro IPR029026 tRNA_m1G_MTases_N # InterPro IPR029028 Alpha/beta_knot_MTases # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # Organism RLMH_ECOLI Escherichia coli (strain K12) # PATRIC 32116455 VBIEscCol129921_0667 # PDB 1NS5 X-ray; 1.68 A; A/B=1-155 # PIR B24995 QQECP1 # PIRSF PIRSF004505 MT_bac # Pfam PF02590 SPOUT_MTase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RLMH_ECOLI Ribosomal RNA large subunit methyltransferase H # RefSeq NP_415169 NC_000913.3 # RefSeq WP_000776104 NZ_LN832404.1 # SIMILARITY Belongs to the RNA methyltransferase RlmH family. {ECO 0000305}. # SUBCELLULAR LOCATION RLMH_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Homodimer. {ECO 0000269|Ref.8}. # SUPFAM SSF75217 SSF75217 # TIGRFAMs TIGR00246 tRNA_RlmH_YbeA # eggNOG COG1576 LUCA # eggNOG ENOG4108UXA Bacteria BLAST swissprot:RLMH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RLMH_ECOLI BioCyc ECOL316407:JW0631-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0631-MONOMER BioCyc EcoCyc:EG11254-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11254-MONOMER BioCyc MetaCyc:EG11254-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11254-MONOMER COG COG1576 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1576 DIP DIP-11357N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11357N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1432-1033.1986.tb09961.x http://dx.doi.org/10.1111/j.1432-1033.1986.tb09961.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1261/rna.1186608 http://dx.doi.org/10.1261/rna.1186608 DOI 10.1261/rna.1198108 http://dx.doi.org/10.1261/rna.1198108 EC_number EC:2.1.1.177 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.177 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EMBL X04516 http://www.ebi.ac.uk/ena/data/view/X04516 ENZYME 2.1.1.177 http://enzyme.expasy.org/EC/2.1.1.177 EchoBASE EB1234 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1234 EcoGene EG11254 http://www.ecogene.org/geneInfo.php?eg_id=EG11254 EnsemblBacteria AAC73737 http://www.ensemblgenomes.org/id/AAC73737 EnsemblBacteria AAC73737 http://www.ensemblgenomes.org/id/AAC73737 EnsemblBacteria BAA35283 http://www.ensemblgenomes.org/id/BAA35283 EnsemblBacteria BAA35283 http://www.ensemblgenomes.org/id/BAA35283 EnsemblBacteria BAA35283 http://www.ensemblgenomes.org/id/BAA35283 EnsemblBacteria b0636 http://www.ensemblgenomes.org/id/b0636 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0042803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803 GO_function GO:0043022 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043022 GO_function GO:0070038 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070038 GO_process GO:0031167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031167 GO_process GO:0070475 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070475 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.1280.10 http://www.cathdb.info/version/latest/superfamily/3.40.1280.10 GeneID 945239 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945239 HAMAP MF_00658 http://hamap.expasy.org/unirule/MF_00658 HOGENOM HOG000218434 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218434&db=HOGENOM6 InParanoid P0A8I8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8I8 IntAct P0A8I8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8I8* IntEnz 2.1.1.177 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.177 InterPro IPR003742 http://www.ebi.ac.uk/interpro/entry/IPR003742 InterPro IPR016051 http://www.ebi.ac.uk/interpro/entry/IPR016051 InterPro IPR029026 http://www.ebi.ac.uk/interpro/entry/IPR029026 InterPro IPR029028 http://www.ebi.ac.uk/interpro/entry/IPR029028 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW0631 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0631 KEGG_Gene eco:b0636 http://www.genome.jp/dbget-bin/www_bget?eco:b0636 KEGG_Orthology KO:K00783 http://www.genome.jp/dbget-bin/www_bget?KO:K00783 MINT MINT-1251153 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1251153 OMA LGSYRDQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LGSYRDQ PDB 1NS5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1NS5 PDBsum 1NS5 http://www.ebi.ac.uk/pdbsum/1NS5 PSORT swissprot:RLMH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RLMH_ECOLI PSORT-B swissprot:RLMH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RLMH_ECOLI PSORT2 swissprot:RLMH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RLMH_ECOLI Pfam PF02590 http://pfam.xfam.org/family/PF02590 Phobius swissprot:RLMH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RLMH_ECOLI PhylomeDB P0A8I8 http://phylomedb.org/?seqid=P0A8I8 ProteinModelPortal P0A8I8 http://www.proteinmodelportal.org/query/uniprot/P0A8I8 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18755835 http://www.ncbi.nlm.nih.gov/pubmed/18755835 PubMed 18755836 http://www.ncbi.nlm.nih.gov/pubmed/18755836 PubMed 3533535 http://www.ncbi.nlm.nih.gov/pubmed/3533535 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415169 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415169 RefSeq WP_000776104 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000776104 SMR P0A8I8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8I8 STRING 511145.b0636 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0636&targetmode=cogs STRING COG1576 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1576&targetmode=cogs SUPFAM SSF75217 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF75217 TIGRFAMs TIGR00246 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00246 UniProtKB RLMH_ECOLI http://www.uniprot.org/uniprot/RLMH_ECOLI UniProtKB-AC P0A8I8 http://www.uniprot.org/uniprot/P0A8I8 charge swissprot:RLMH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RLMH_ECOLI eggNOG COG1576 http://eggnogapi.embl.de/nog_data/html/tree/COG1576 eggNOG ENOG4108UXA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UXA epestfind swissprot:RLMH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RLMH_ECOLI garnier swissprot:RLMH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RLMH_ECOLI helixturnhelix swissprot:RLMH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RLMH_ECOLI hmoment swissprot:RLMH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RLMH_ECOLI iep swissprot:RLMH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RLMH_ECOLI inforesidue swissprot:RLMH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RLMH_ECOLI octanol swissprot:RLMH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RLMH_ECOLI pepcoil swissprot:RLMH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RLMH_ECOLI pepdigest swissprot:RLMH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RLMH_ECOLI pepinfo swissprot:RLMH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RLMH_ECOLI pepnet swissprot:RLMH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RLMH_ECOLI pepstats swissprot:RLMH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RLMH_ECOLI pepwheel swissprot:RLMH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RLMH_ECOLI pepwindow swissprot:RLMH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RLMH_ECOLI sigcleave swissprot:RLMH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RLMH_ECOLI ## Database ID URL or Descriptions # BioGrid 4259985 13 # EcoGene EG12134 rhtA # FUNCTION RHTA_ECOLI Involved in the efflux of threonine and homoserine. Can also export other amino acids such as proline, serine, histidine and cysteine. {ECO 0000269|PubMed 12648727}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015565 threonine efflux transmembrane transporter activity; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # InterPro IPR000620 EamA_dom # KEGG_Brite ko02000 Transporters # Organism RHTA_ECOLI Escherichia coli (strain K12) # PATRIC 32116829 VBIEscCol129921_0840 # PIR E64818 E64818 # Pfam PF00892 EamA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RHTA_ECOLI Threonine/homoserine exporter RhtA # RefSeq NP_415334 NC_000913.3 # RefSeq WP_001295297 NZ_LN832404.1 # SIMILARITY Belongs to the drug/metabolite transporter (DMT) superfamily. 10 TMS drug/metabolite exporter (DME) (TC 2.A.7.3) family. {ECO 0000305}. # SIMILARITY Contains 2 EamA domains. {ECO 0000305}. # SUBCELLULAR LOCATION RHTA_ECOLI Cell inner membrane {ECO 0000269|PubMed 12648727}; Multi-pass membrane protein {ECO 0000269|PubMed 12648727}. # TCDB 2.A.7.3 the drug/metabolite transporter (dmt) superfamily # eggNOG COG5006 LUCA # eggNOG ENOG4107AQZ Bacteria BLAST swissprot:RHTA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RHTA_ECOLI BioCyc ECOL316407:JW0798-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0798-MONOMER BioCyc EcoCyc:EG12134-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12134-MONOMER BioCyc MetaCyc:EG12134-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12134-MONOMER COG COG5006 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG5006 DOI 10.1016/S0923-2508(03)00036-6 http://dx.doi.org/10.1016/S0923-2508(03)00036-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U04242 http://www.ebi.ac.uk/ena/data/view/U04242 EchoBASE EB2055 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2055 EcoGene EG12134 http://www.ecogene.org/geneInfo.php?eg_id=EG12134 EnsemblBacteria AAC73900 http://www.ensemblgenomes.org/id/AAC73900 EnsemblBacteria AAC73900 http://www.ensemblgenomes.org/id/AAC73900 EnsemblBacteria BAA35485 http://www.ensemblgenomes.org/id/BAA35485 EnsemblBacteria BAA35485 http://www.ensemblgenomes.org/id/BAA35485 EnsemblBacteria BAA35485 http://www.ensemblgenomes.org/id/BAA35485 EnsemblBacteria b0813 http://www.ensemblgenomes.org/id/b0813 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015565 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GeneID 947045 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947045 HOGENOM HOG000283695 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000283695&db=HOGENOM6 InParanoid P0AA67 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AA67 InterPro IPR000620 http://www.ebi.ac.uk/interpro/entry/IPR000620 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0798 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0798 KEGG_Gene eco:b0813 http://www.genome.jp/dbget-bin/www_bget?eco:b0813 KEGG_Orthology KO:K11939 http://www.genome.jp/dbget-bin/www_bget?KO:K11939 OMA MALGGMN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MALGGMN PSORT swissprot:RHTA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RHTA_ECOLI PSORT-B swissprot:RHTA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RHTA_ECOLI PSORT2 swissprot:RHTA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RHTA_ECOLI Pfam PF00892 http://pfam.xfam.org/family/PF00892 Phobius swissprot:RHTA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RHTA_ECOLI PhylomeDB P0AA67 http://phylomedb.org/?seqid=P0AA67 ProteinModelPortal P0AA67 http://www.proteinmodelportal.org/query/uniprot/P0AA67 PubMed 12648727 http://www.ncbi.nlm.nih.gov/pubmed/12648727 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8021175 http://www.ncbi.nlm.nih.gov/pubmed/8021175 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415334 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415334 RefSeq WP_001295297 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295297 STRING 511145.b0813 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0813&targetmode=cogs STRING COG5006 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG5006&targetmode=cogs TCDB 2.A.7.3 http://www.tcdb.org/search/result.php?tc=2.A.7.3 UniProtKB RHTA_ECOLI http://www.uniprot.org/uniprot/RHTA_ECOLI UniProtKB-AC P0AA67 http://www.uniprot.org/uniprot/P0AA67 charge swissprot:RHTA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RHTA_ECOLI eggNOG COG5006 http://eggnogapi.embl.de/nog_data/html/tree/COG5006 eggNOG ENOG4107AQZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107AQZ epestfind swissprot:RHTA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RHTA_ECOLI garnier swissprot:RHTA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RHTA_ECOLI helixturnhelix swissprot:RHTA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RHTA_ECOLI hmoment swissprot:RHTA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RHTA_ECOLI iep swissprot:RHTA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RHTA_ECOLI inforesidue swissprot:RHTA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RHTA_ECOLI octanol swissprot:RHTA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RHTA_ECOLI pepcoil swissprot:RHTA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RHTA_ECOLI pepdigest swissprot:RHTA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RHTA_ECOLI pepinfo swissprot:RHTA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RHTA_ECOLI pepnet swissprot:RHTA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RHTA_ECOLI pepstats swissprot:RHTA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RHTA_ECOLI pepwheel swissprot:RHTA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RHTA_ECOLI pepwindow swissprot:RHTA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RHTA_ECOLI sigcleave swissprot:RHTA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RHTA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260248 170 # EcoGene EG11303 ydfD # InterPro IPR009954 DUF1482 # Organism YDFD_ECOLI Escherichia coli (strain K12) # PATRIC 32118454 VBIEscCol129921_1647 # PIR B64913 Q3ECD7 # Pfam PF07358 DUF1482 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDFD_ECOLI Uncharacterized protein YdfD # RefSeq NP_416093 NC_000913.3 # RefSeq WP_001083297 NZ_LN832404.1 # eggNOG ENOG4106G8A Bacteria # eggNOG ENOG410Y7W3 LUCA BLAST swissprot:YDFD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDFD_ECOLI BioCyc ECOL316407:JW1567-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1567-MONOMER BioCyc EcoCyc:EG11303-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11303-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/16.14.6327 http://dx.doi.org/10.1093/nar/16.14.6327 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X07465 http://www.ebi.ac.uk/ena/data/view/X07465 EchoBASE EB1280 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1280 EcoGene EG11303 http://www.ecogene.org/geneInfo.php?eg_id=EG11303 EnsemblBacteria AAC74648 http://www.ensemblgenomes.org/id/AAC74648 EnsemblBacteria AAC74648 http://www.ensemblgenomes.org/id/AAC74648 EnsemblBacteria BAA15280 http://www.ensemblgenomes.org/id/BAA15280 EnsemblBacteria BAA15280 http://www.ensemblgenomes.org/id/BAA15280 EnsemblBacteria BAA15280 http://www.ensemblgenomes.org/id/BAA15280 EnsemblBacteria b1576 http://www.ensemblgenomes.org/id/b1576 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946102 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946102 HOGENOM HOG000121196 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000121196&db=HOGENOM6 InterPro IPR009954 http://www.ebi.ac.uk/interpro/entry/IPR009954 KEGG_Gene ecj:JW1567 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1567 KEGG_Gene eco:b1576 http://www.genome.jp/dbget-bin/www_bget?eco:b1576 OMA QYNIEIP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QYNIEIP PSORT swissprot:YDFD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDFD_ECOLI PSORT-B swissprot:YDFD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDFD_ECOLI PSORT2 swissprot:YDFD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDFD_ECOLI Pfam PF07358 http://pfam.xfam.org/family/PF07358 Phobius swissprot:YDFD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDFD_ECOLI ProteinModelPortal P29010 http://www.proteinmodelportal.org/query/uniprot/P29010 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3041373 http://www.ncbi.nlm.nih.gov/pubmed/3041373 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416093 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416093 RefSeq WP_001083297 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001083297 STRING 511145.b1576 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1576&targetmode=cogs UniProtKB YDFD_ECOLI http://www.uniprot.org/uniprot/YDFD_ECOLI UniProtKB-AC P29010 http://www.uniprot.org/uniprot/P29010 charge swissprot:YDFD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDFD_ECOLI eggNOG ENOG4106G8A http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106G8A eggNOG ENOG410Y7W3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y7W3 epestfind swissprot:YDFD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDFD_ECOLI garnier swissprot:YDFD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDFD_ECOLI helixturnhelix swissprot:YDFD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDFD_ECOLI hmoment swissprot:YDFD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDFD_ECOLI iep swissprot:YDFD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDFD_ECOLI inforesidue swissprot:YDFD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDFD_ECOLI octanol swissprot:YDFD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDFD_ECOLI pepcoil swissprot:YDFD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDFD_ECOLI pepdigest swissprot:YDFD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDFD_ECOLI pepinfo swissprot:YDFD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDFD_ECOLI pepnet swissprot:YDFD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDFD_ECOLI pepstats swissprot:YDFD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDFD_ECOLI pepwheel swissprot:YDFD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDFD_ECOLI pepwindow swissprot:YDFD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDFD_ECOLI sigcleave swissprot:YDFD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDFD_ECOLI ## Database ID URL or Descriptions # BioGrid 4260628 8 # EcoGene EG13205 yfjS # FUNCTION YFJS_ECOLI Does not induce degP when overexpressed unless it is mutated to resemble YafY. {ECO 0000269|PubMed 15252048}. # GO_component GO:0005886 plasma membrane; IDA:UniProtKB. # GOslim_component GO:0005886 plasma membrane # Organism YFJS_ECOLI Escherichia coli (strain K12) # PATRIC 32120663 VBIEscCol129921_2730 # PIR F65042 F65042 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFJS_ECOLI Lipoprotein YfjS # RefSeq NP_417124 NC_000913.3 # RefSeq WP_000824222 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA79804.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY To E.coli YafY. {ECO 0000305}. # SUBCELLULAR LOCATION YFJS_ECOLI Cell inner membrane {ECO 0000305|PubMed 15252048}; Lipid-anchor {ECO 0000305|PubMed 15252048}. BLAST swissprot:YFJS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFJS_ECOLI BioCyc ECOL316407:JW5921-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5921-MONOMER BioCyc EcoCyc:G7371-MONOMER http://biocyc.org/getid?id=EcoCyc:G7371-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M406390200 http://dx.doi.org/10.1074/jbc.M406390200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36840 http://www.ebi.ac.uk/ena/data/view/U36840 EcoGene EG13205 http://www.ecogene.org/geneInfo.php?eg_id=EG13205 EnsemblBacteria AAC75684 http://www.ensemblgenomes.org/id/AAC75684 EnsemblBacteria AAC75684 http://www.ensemblgenomes.org/id/AAC75684 EnsemblBacteria BAE76771 http://www.ensemblgenomes.org/id/BAE76771 EnsemblBacteria BAE76771 http://www.ensemblgenomes.org/id/BAE76771 EnsemblBacteria BAE76771 http://www.ensemblgenomes.org/id/BAE76771 EnsemblBacteria b2636 http://www.ensemblgenomes.org/id/b2636 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 945668 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945668 HOGENOM HOG000028675 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000028675&db=HOGENOM6 KEGG_Gene ecj:JW5921 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5921 KEGG_Gene eco:b2636 http://www.genome.jp/dbget-bin/www_bget?eco:b2636 OMA SHKSDIA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SHKSDIA PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YFJS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFJS_ECOLI PSORT-B swissprot:YFJS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFJS_ECOLI PSORT2 swissprot:YFJS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFJS_ECOLI Phobius swissprot:YFJS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFJS_ECOLI ProteinModelPortal O52982 http://www.proteinmodelportal.org/query/uniprot/O52982 PubMed 15252048 http://www.ncbi.nlm.nih.gov/pubmed/15252048 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417124 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417124 RefSeq WP_000824222 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000824222 SMR O52982 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O52982 STRING 511145.b2636 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2636&targetmode=cogs UniProtKB YFJS_ECOLI http://www.uniprot.org/uniprot/YFJS_ECOLI UniProtKB-AC O52982 http://www.uniprot.org/uniprot/O52982 charge swissprot:YFJS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFJS_ECOLI epestfind swissprot:YFJS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFJS_ECOLI garnier swissprot:YFJS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFJS_ECOLI helixturnhelix swissprot:YFJS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFJS_ECOLI hmoment swissprot:YFJS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFJS_ECOLI iep swissprot:YFJS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFJS_ECOLI inforesidue swissprot:YFJS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFJS_ECOLI octanol swissprot:YFJS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFJS_ECOLI pepcoil swissprot:YFJS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFJS_ECOLI pepdigest swissprot:YFJS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFJS_ECOLI pepinfo swissprot:YFJS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFJS_ECOLI pepnet swissprot:YFJS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFJS_ECOLI pepstats swissprot:YFJS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFJS_ECOLI pepwheel swissprot:YFJS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFJS_ECOLI pepwindow swissprot:YFJS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFJS_ECOLI sigcleave swissprot:YFJS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFJS_ECOLI ## Database ID URL or Descriptions # BioGrid 4261814 6 # EcoGene EG11671 atoE # FUNCTION ATOE_ECOLI Responsible for the intake of short-chain fatty acids. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006810 transport; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006810 transport # InterPro IPR006160 SCFA_transpt_AtoE # InterPro IPR006161 CHP00366 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko02020 Two-component system # Organism ATOE_ECOLI Escherichia coli (strain K12) # PATRIC 32119805 VBIEscCol129921_2312 # PIR E64992 E64992 # Pfam PF02667 SCFA_trans # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ATOE_ECOLI Short-chain fatty acids transporter # RefSeq NP_416727 NC_000913.3 # RefSeq WP_000580275 NZ_LN832404.1 # SUBCELLULAR LOCATION ATOE_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.73.1 the short chain fatty acid uptake (atoe) family # TIGRFAMs TIGR00366 TIGR00366 # eggNOG COG2031 LUCA # eggNOG ENOG4105CRW Bacteria BLAST swissprot:ATOE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ATOE_ECOLI BioCyc ECOL316407:JW2217-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2217-MONOMER BioCyc EcoCyc:EG11671-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11671-MONOMER BioCyc MetaCyc:EG11671-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11671-MONOMER COG COG2031 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2031 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1622 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1622 EcoGene EG11671 http://www.ecogene.org/geneInfo.php?eg_id=EG11671 EnsemblBacteria AAC75283 http://www.ensemblgenomes.org/id/AAC75283 EnsemblBacteria AAC75283 http://www.ensemblgenomes.org/id/AAC75283 EnsemblBacteria BAA16019 http://www.ensemblgenomes.org/id/BAA16019 EnsemblBacteria BAA16019 http://www.ensemblgenomes.org/id/BAA16019 EnsemblBacteria BAA16019 http://www.ensemblgenomes.org/id/BAA16019 EnsemblBacteria b2223 http://www.ensemblgenomes.org/id/b2223 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 946721 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946721 HOGENOM HOG000295152 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000295152&db=HOGENOM6 InParanoid P76460 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76460 InterPro IPR006160 http://www.ebi.ac.uk/interpro/entry/IPR006160 InterPro IPR006161 http://www.ebi.ac.uk/interpro/entry/IPR006161 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW2217 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2217 KEGG_Gene eco:b2223 http://www.genome.jp/dbget-bin/www_bget?eco:b2223 KEGG_Orthology KO:K02106 http://www.genome.jp/dbget-bin/www_bget?KO:K02106 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA YSGFVIW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YSGFVIW PSORT swissprot:ATOE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ATOE_ECOLI PSORT-B swissprot:ATOE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ATOE_ECOLI PSORT2 swissprot:ATOE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ATOE_ECOLI Pfam PF02667 http://pfam.xfam.org/family/PF02667 Phobius swissprot:ATOE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ATOE_ECOLI PhylomeDB P76460 http://phylomedb.org/?seqid=P76460 ProteinModelPortal P76460 http://www.proteinmodelportal.org/query/uniprot/P76460 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416727 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416727 RefSeq WP_000580275 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000580275 STRING 511145.b2223 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2223&targetmode=cogs STRING COG2031 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2031&targetmode=cogs TCDB 2.A.73.1 http://www.tcdb.org/search/result.php?tc=2.A.73.1 TIGRFAMs TIGR00366 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00366 UniProtKB ATOE_ECOLI http://www.uniprot.org/uniprot/ATOE_ECOLI UniProtKB-AC P76460 http://www.uniprot.org/uniprot/P76460 charge swissprot:ATOE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ATOE_ECOLI eggNOG COG2031 http://eggnogapi.embl.de/nog_data/html/tree/COG2031 eggNOG ENOG4105CRW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CRW epestfind swissprot:ATOE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ATOE_ECOLI garnier swissprot:ATOE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ATOE_ECOLI helixturnhelix swissprot:ATOE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ATOE_ECOLI hmoment swissprot:ATOE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ATOE_ECOLI iep swissprot:ATOE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ATOE_ECOLI inforesidue swissprot:ATOE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ATOE_ECOLI octanol swissprot:ATOE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ATOE_ECOLI pepcoil swissprot:ATOE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ATOE_ECOLI pepdigest swissprot:ATOE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ATOE_ECOLI pepinfo swissprot:ATOE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ATOE_ECOLI pepnet swissprot:ATOE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ATOE_ECOLI pepstats swissprot:ATOE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ATOE_ECOLI pepwheel swissprot:ATOE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ATOE_ECOLI pepwindow swissprot:ATOE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ATOE_ECOLI sigcleave swissprot:ATOE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ATOE_ECOLI ## Database ID URL or Descriptions # BioGrid 4262498 546 # DISRUPTION PHENOTYPE Double deletion mutant FtsEX grows well on plates with LB medium with 1% NaCl forming healthy colonies at 30 degrees Celsius, whereas at 37 or 42 degrees Celsius, the colonies are very tiny and sick. In culture medium it exhibits mild elongation of cells at 30 degrees Celsius, and become very extensive at higher temperatures. This double mutant does not grow on LB culture medium without NaCl (LBON) at any temperature, possibly due to excessive lethal filamentation. Supplementation with any of a variety of osmolytes, such as glucose, sucrose, glycerol, or NaCl, completely rescues the growth on LBON medium. Though the growth is completely inhibited on LBON plates, the cultures grown in LBON broth show an initial increase in cell mass before the cessation of growth, and at this stage, the culture is extremely filamentous. The filaments grown in LB at 42 degrees Celsius or in LBON at 30 degrees Celsius are very long and appear to have elongated cells. They are normal and regularly spaced without any significant chromosomal aberrations or partition defects. {ECO:0000269|PubMed 17071757}. # EcoGene EG10345 ftsX # FUNCTION FTSX_ECOLI Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring. Encoded in an operon consisting of genes ftsY, ftsE and ftsX. {ECO 0000269|PubMed 10048040, ECO 0000269|PubMed 14729705}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0009276 Gram-negative-bacterium-type cell wall; IDA:UniProtKB. # GO_component GO:0016021 integral component of membrane; IDA:EcoliWiki. # GO_component GO:0032153 cell division site; IDA:EcoliWiki. # GO_process GO:0007049 cell cycle; IEA:UniProtKB-KW. # GO_process GO:0051301 cell division; IGI:UniProtKB. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005618 cell wall # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0007049 cell cycle # GOslim_process GO:0051301 cell division # IntAct P0AC30 5 # InterPro IPR003838 ABC_permease_dom # InterPro IPR004513 ABC_transpt_FtsX # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00256 Cell division transport system # KEGG_Brite ko02000 Transporters # KEGG_Brite ko03036 Chromosome # KEGG_Pathway ko02010 ABC transporters # MISCELLANEOUS FTSX_ECOLI Overexpression leads to strong inhibition of growth, cell filamentation and eventually cell death. # Organism FTSX_ECOLI Escherichia coli (strain K12) # PATRIC 32122368 VBIEscCol129921_3561 # PIR S03132 CEECFX # PIRSF PIRSF003097 FtsX # Pfam PF02687 FtsX # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FTSX_ECOLI Cell division protein FtsX # RefSeq NP_417919 NC_000913.3 # RefSeq WP_001042003 NZ_LN832404.1 # SIMILARITY Belongs to the ABC-4 integral membrane protein family. FtsX subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION FTSX_ECOLI Cell inner membrane {ECO 0000269|PubMed 10048040, ECO 0000269|PubMed 14729705, ECO 0000269|PubMed 3323846}; Multi-pass membrane protein {ECO 0000269|PubMed 10048040, ECO 0000269|PubMed 14729705, ECO 0000269|PubMed 3323846}. Note=Localizes to the septal ring at the later stages of cell growth and remains there until division is complete. This localization is dependent on localization of FtsZ, FtsA and ZipA, but not on the downstream division proteins FtsK, FtsQ or FtsI. # SUBUNIT FTSX_ECOLI Forms a membrane-associated complex with FtsE. # TIGRFAMs TIGR00439 ftsX # eggNOG COG2177 LUCA # eggNOG ENOG4105CRP Bacteria BLAST swissprot:FTSX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FTSX_ECOLI BioCyc ECOL316407:JW3427-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3427-MONOMER BioCyc EcoCyc:FTSX-MONOMER http://biocyc.org/getid?id=EcoCyc:FTSX-MONOMER COG COG2177 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2177 DIP DIP-35993N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35993N DOI 10.1007/BF00327204 http://dx.doi.org/10.1007/BF00327204 DOI 10.1007/BF00330978 http://dx.doi.org/10.1007/BF00330978 DOI 10.1007/BF02428043 http://dx.doi.org/10.1007/BF02428043 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1999.01245.x http://dx.doi.org/10.1046/j.1365-2958.1999.01245.x DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01347-06 http://dx.doi.org/10.1128/JB.01347-06 DOI 10.1128/JB.186.3.785-793.2004 http://dx.doi.org/10.1128/JB.186.3.785-793.2004 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X04398 http://www.ebi.ac.uk/ena/data/view/X04398 EchoBASE EB0341 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0341 EcoGene EG10345 http://www.ecogene.org/geneInfo.php?eg_id=EG10345 EnsemblBacteria AAC76487 http://www.ensemblgenomes.org/id/AAC76487 EnsemblBacteria AAC76487 http://www.ensemblgenomes.org/id/AAC76487 EnsemblBacteria BAE77831 http://www.ensemblgenomes.org/id/BAE77831 EnsemblBacteria BAE77831 http://www.ensemblgenomes.org/id/BAE77831 EnsemblBacteria BAE77831 http://www.ensemblgenomes.org/id/BAE77831 EnsemblBacteria b3462 http://www.ensemblgenomes.org/id/b3462 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0009276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009276 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0032153 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032153 GO_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005618 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GeneID 947969 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947969 HOGENOM HOG000270397 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000270397&db=HOGENOM6 InParanoid P0AC30 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AC30 IntAct P0AC30 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AC30* InterPro IPR003838 http://www.ebi.ac.uk/interpro/entry/IPR003838 InterPro IPR004513 http://www.ebi.ac.uk/interpro/entry/IPR004513 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene ecj:JW3427 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3427 KEGG_Gene eco:b3462 http://www.genome.jp/dbget-bin/www_bget?eco:b3462 KEGG_Orthology KO:K09811 http://www.genome.jp/dbget-bin/www_bget?KO:K09811 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA ITIFARR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ITIFARR PSORT swissprot:FTSX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FTSX_ECOLI PSORT-B swissprot:FTSX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FTSX_ECOLI PSORT2 swissprot:FTSX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FTSX_ECOLI Pfam PF02687 http://pfam.xfam.org/family/PF02687 Phobius swissprot:FTSX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FTSX_ECOLI PhylomeDB P0AC30 http://phylomedb.org/?seqid=P0AC30 ProteinModelPortal P0AC30 http://www.proteinmodelportal.org/query/uniprot/P0AC30 PubMed 10048040 http://www.ncbi.nlm.nih.gov/pubmed/10048040 PubMed 14729705 http://www.ncbi.nlm.nih.gov/pubmed/14729705 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17071757 http://www.ncbi.nlm.nih.gov/pubmed/17071757 PubMed 3025556 http://www.ncbi.nlm.nih.gov/pubmed/3025556 PubMed 3323846 http://www.ncbi.nlm.nih.gov/pubmed/3323846 PubMed 6394955 http://www.ncbi.nlm.nih.gov/pubmed/6394955 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417919 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417919 RefSeq WP_001042003 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001042003 SMR P0AC30 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AC30 STRING 511145.b3462 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3462&targetmode=cogs STRING COG2177 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2177&targetmode=cogs TIGRFAMs TIGR00439 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00439 UniProtKB FTSX_ECOLI http://www.uniprot.org/uniprot/FTSX_ECOLI UniProtKB-AC P0AC30 http://www.uniprot.org/uniprot/P0AC30 charge swissprot:FTSX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FTSX_ECOLI eggNOG COG2177 http://eggnogapi.embl.de/nog_data/html/tree/COG2177 eggNOG ENOG4105CRP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CRP epestfind swissprot:FTSX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FTSX_ECOLI garnier swissprot:FTSX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FTSX_ECOLI helixturnhelix swissprot:FTSX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FTSX_ECOLI hmoment swissprot:FTSX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FTSX_ECOLI iep swissprot:FTSX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FTSX_ECOLI inforesidue swissprot:FTSX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FTSX_ECOLI octanol swissprot:FTSX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FTSX_ECOLI pepcoil swissprot:FTSX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FTSX_ECOLI pepdigest swissprot:FTSX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FTSX_ECOLI pepinfo swissprot:FTSX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FTSX_ECOLI pepnet swissprot:FTSX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FTSX_ECOLI pepstats swissprot:FTSX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FTSX_ECOLI pepwheel swissprot:FTSX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FTSX_ECOLI pepwindow swissprot:FTSX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FTSX_ECOLI sigcleave swissprot:FTSX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FTSX_ECOLI ## Database ID URL or Descriptions # BioGrid 4259892 10 # COFACTOR YBDH_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000250}; Note=Binds 1 zinc ion per subunit. {ECO 0000250}; # EcoGene EG12692 ybdH # GO_function GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IBA:GO_Central. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006071 glycerol metabolic process; IBA:GO_Central. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0044281 small molecule metabolic process # INTERACTION YBDH_ECOLI Self; NbExp=3; IntAct=EBI-553586, EBI-553586; P0AFT8 yeiW; NbExp=3; IntAct=EBI-553586, EBI-8767954; # IntAct P45579 11 # InterPro IPR001670 ADH_Fe # InterPro IPR018211 ADH_Fe_CS # KEGG_Brite ko01000 Enzymes # Organism YBDH_ECOLI Escherichia coli (strain K12) # PATRIC 32116376 VBIEscCol129921_0628 # PIR E64793 E64793 # PROSITE PS00913 ADH_IRON_1 # Pfam PF00465 Fe-ADH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBDH_ECOLI Uncharacterized oxidoreductase YbdH # RefSeq NP_415132 NC_000913.3 # RefSeq WP_001120441 NZ_LN832404.1 # SIMILARITY Belongs to the iron-containing alcohol dehydrogenase family. {ECO 0000305}. # eggNOG COG0371 LUCA # eggNOG ENOG4107SCQ Bacteria BLAST swissprot:YBDH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBDH_ECOLI BioCyc ECOL316407:JW0592-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0592-MONOMER BioCyc EcoCyc:EG12692-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12692-MONOMER COG COG0371 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0371 DIP DIP-11347N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11347N DOI 10.1016/0022-2836(91)90879-B http://dx.doi.org/10.1016/0022-2836(91)90879-B DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.1.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EMBL X52904 http://www.ebi.ac.uk/ena/data/view/X52904 ENZYME 1.1.-.- http://enzyme.expasy.org/EC/1.1.-.- EchoBASE EB2555 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2555 EcoGene EG12692 http://www.ecogene.org/geneInfo.php?eg_id=EG12692 EnsemblBacteria AAC73700 http://www.ensemblgenomes.org/id/AAC73700 EnsemblBacteria AAC73700 http://www.ensemblgenomes.org/id/AAC73700 EnsemblBacteria BAA35229 http://www.ensemblgenomes.org/id/BAA35229 EnsemblBacteria BAA35229 http://www.ensemblgenomes.org/id/BAA35229 EnsemblBacteria BAA35229 http://www.ensemblgenomes.org/id/BAA35229 EnsemblBacteria b0599 http://www.ensemblgenomes.org/id/b0599 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016616 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016616 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006071 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 945212 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945212 HOGENOM HOG000031783 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000031783&db=HOGENOM6 InParanoid P45579 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45579 IntAct P45579 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45579* IntEnz 1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1 InterPro IPR001670 http://www.ebi.ac.uk/interpro/entry/IPR001670 InterPro IPR018211 http://www.ebi.ac.uk/interpro/entry/IPR018211 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0592 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0592 KEGG_Gene eco:b0599 http://www.genome.jp/dbget-bin/www_bget?eco:b0599 KEGG_Orthology KO:K08317 http://www.genome.jp/dbget-bin/www_bget?KO:K08317 MINT MINT-1302765 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1302765 OMA VPGPANY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VPGPANY PROSITE PS00913 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00913 PSORT swissprot:YBDH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBDH_ECOLI PSORT-B swissprot:YBDH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBDH_ECOLI PSORT2 swissprot:YBDH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBDH_ECOLI Pfam PF00465 http://pfam.xfam.org/family/PF00465 Phobius swissprot:YBDH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBDH_ECOLI PhylomeDB P45579 http://phylomedb.org/?seqid=P45579 ProteinModelPortal P45579 http://www.proteinmodelportal.org/query/uniprot/P45579 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1848300 http://www.ncbi.nlm.nih.gov/pubmed/1848300 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415132 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415132 RefSeq WP_001120441 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001120441 SMR P45579 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45579 STRING 511145.b0599 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0599&targetmode=cogs STRING COG0371 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0371&targetmode=cogs UniProtKB YBDH_ECOLI http://www.uniprot.org/uniprot/YBDH_ECOLI UniProtKB-AC P45579 http://www.uniprot.org/uniprot/P45579 charge swissprot:YBDH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBDH_ECOLI eggNOG COG0371 http://eggnogapi.embl.de/nog_data/html/tree/COG0371 eggNOG ENOG4107SCQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107SCQ epestfind swissprot:YBDH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBDH_ECOLI garnier swissprot:YBDH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBDH_ECOLI helixturnhelix swissprot:YBDH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBDH_ECOLI hmoment swissprot:YBDH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBDH_ECOLI iep swissprot:YBDH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBDH_ECOLI inforesidue swissprot:YBDH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBDH_ECOLI octanol swissprot:YBDH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBDH_ECOLI pepcoil swissprot:YBDH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBDH_ECOLI pepdigest swissprot:YBDH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBDH_ECOLI pepinfo swissprot:YBDH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBDH_ECOLI pepnet swissprot:YBDH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBDH_ECOLI pepstats swissprot:YBDH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBDH_ECOLI pepwheel swissprot:YBDH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBDH_ECOLI pepwindow swissprot:YBDH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBDH_ECOLI sigcleave swissprot:YBDH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBDH_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES SUFC_ECOLI Kinetic parameters KM=0.29 mM for ATP {ECO 0000269|PubMed 12554644}; Vmax=4.45 umol/min/mg enzyme {ECO 0000269|PubMed 12554644}; # BioGrid 4260279 53 # CDD cd03217 ABC_FeS_Assembly # EcoGene EG13964 sufC # FUNCTION SUFC_ECOLI Has low ATPase activity. The SufBCD complex acts synergistically with SufE to stimulate the cysteine desulfurase activity of SufS. The SufBCD complex contributes to the assembly or repair of oxygen-labile iron-sulfur clusters under oxidative stress. May facilitate iron uptake from extracellular iron chelators under iron limitation. {ECO 0000269|PubMed 12554644, ECO 0000269|PubMed 12941942}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016887 ATPase activity; IEA:InterPro. # GO_process GO:0006810 transport; IEA:UniProtKB-KW. # GO_process GO:0016226 iron-sulfur cluster assembly; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0006810 transport # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.300 -; 1. # INTERACTION SUFC_ECOLI P77667 sufA; NbExp=5; IntAct=EBI-561601, EBI-1125011; P77522 sufB; NbExp=13; IntAct=EBI-561601, EBI-562758; P77689 sufD; NbExp=8; IntAct=EBI-561601, EBI-562751; # IntAct P77499 16 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR010230 FeS-cluster_ATPase_SufC # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko02000 Transporters # Organism SUFC_ECOLI Escherichia coli (strain K12) # PATRIC 32118670 VBIEscCol129921_1753 # PDB 2D3W X-ray; 2.50 A; A/B/C/D=1-248 # PDB 2ZU0 X-ray; 2.20 A; C/D=1-248 # PDB 5AWF X-ray; 2.96 A; C/D/G/H=1-248 # PDB 5AWG X-ray; 4.28 A; C/D/G/H=1-248 # PIR B64926 B64926 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # Pfam PF00005 ABC_tran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SUFC_ECOLI Probable ATP-dependent transporter SufC # RefSeq NP_416197 NC_000913.3 # RefSeq WP_000948863 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. Ycf16 family. {ECO 0000305}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA # SUBCELLULAR LOCATION SUFC_ECOLI Cytoplasm {ECO 0000269|PubMed 12554644}. # SUBUNIT SUFC_ECOLI Part of the SufBCD complex that contains SufB, SufC and SufD. Interacts directly with SufB and SufD. {ECO 0000269|PubMed 12554644, ECO 0000269|PubMed 12941942}. # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR01978 sufC # eggNOG COG0396 LUCA # eggNOG ENOG4105C3K Bacteria BLAST swissprot:SUFC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SUFC_ECOLI BioCyc ECOL316407:JW1672-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1672-MONOMER BioCyc EcoCyc:G6908-MONOMER http://biocyc.org/getid?id=EcoCyc:G6908-MONOMER COG COG0396 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0396 DIP DIP-10939N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10939N DOI 10.1016/j.febslet.2005.11.058 http://dx.doi.org/10.1016/j.febslet.2005.11.058 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M308004200 http://dx.doi.org/10.1074/jbc.M308004200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/emboj/cdg061 http://dx.doi.org/10.1093/emboj/cdg061 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3722 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3722 EcoGene EG13964 http://www.ecogene.org/geneInfo.php?eg_id=EG13964 EnsemblBacteria AAC74752 http://www.ensemblgenomes.org/id/AAC74752 EnsemblBacteria AAC74752 http://www.ensemblgenomes.org/id/AAC74752 EnsemblBacteria BAA15455 http://www.ensemblgenomes.org/id/BAA15455 EnsemblBacteria BAA15455 http://www.ensemblgenomes.org/id/BAA15455 EnsemblBacteria BAA15455 http://www.ensemblgenomes.org/id/BAA15455 EnsemblBacteria b1682 http://www.ensemblgenomes.org/id/b1682 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GO_process GO:0016226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016226 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 946128 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946128 InParanoid P77499 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77499 IntAct P77499 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77499* InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR010230 http://www.ebi.ac.uk/interpro/entry/IPR010230 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1672 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1672 KEGG_Gene eco:b1682 http://www.genome.jp/dbget-bin/www_bget?eco:b1682 KEGG_Orthology KO:K09013 http://www.genome.jp/dbget-bin/www_bget?KO:K09013 MINT MINT-7290829 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-7290829 OMA MAMLEPK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MAMLEPK PDB 2D3W http://www.ebi.ac.uk/pdbe-srv/view/entry/2D3W PDB 2ZU0 http://www.ebi.ac.uk/pdbe-srv/view/entry/2ZU0 PDB 5AWF http://www.ebi.ac.uk/pdbe-srv/view/entry/5AWF PDB 5AWG http://www.ebi.ac.uk/pdbe-srv/view/entry/5AWG PDBsum 2D3W http://www.ebi.ac.uk/pdbsum/2D3W PDBsum 2ZU0 http://www.ebi.ac.uk/pdbsum/2ZU0 PDBsum 5AWF http://www.ebi.ac.uk/pdbsum/5AWF PDBsum 5AWG http://www.ebi.ac.uk/pdbsum/5AWG PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:SUFC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SUFC_ECOLI PSORT-B swissprot:SUFC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SUFC_ECOLI PSORT2 swissprot:SUFC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SUFC_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Phobius swissprot:SUFC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SUFC_ECOLI PhylomeDB P77499 http://phylomedb.org/?seqid=P77499 ProteinModelPortal P77499 http://www.proteinmodelportal.org/query/uniprot/P77499 PubMed 10322040 http://www.ncbi.nlm.nih.gov/pubmed/10322040 PubMed 12554644 http://www.ncbi.nlm.nih.gov/pubmed/12554644 PubMed 12941942 http://www.ncbi.nlm.nih.gov/pubmed/12941942 PubMed 16364320 http://www.ncbi.nlm.nih.gov/pubmed/16364320 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416197 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416197 RefSeq WP_000948863 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000948863 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P77499 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77499 STRING 511145.b1682 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1682&targetmode=cogs STRING COG0396 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0396&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR01978 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01978 UniProtKB SUFC_ECOLI http://www.uniprot.org/uniprot/SUFC_ECOLI UniProtKB-AC P77499 http://www.uniprot.org/uniprot/P77499 charge swissprot:SUFC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SUFC_ECOLI eggNOG COG0396 http://eggnogapi.embl.de/nog_data/html/tree/COG0396 eggNOG ENOG4105C3K http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C3K epestfind swissprot:SUFC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SUFC_ECOLI garnier swissprot:SUFC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SUFC_ECOLI helixturnhelix swissprot:SUFC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SUFC_ECOLI hmoment swissprot:SUFC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SUFC_ECOLI iep swissprot:SUFC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SUFC_ECOLI inforesidue swissprot:SUFC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SUFC_ECOLI octanol swissprot:SUFC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SUFC_ECOLI pepcoil swissprot:SUFC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SUFC_ECOLI pepdigest swissprot:SUFC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SUFC_ECOLI pepinfo swissprot:SUFC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SUFC_ECOLI pepnet swissprot:SUFC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SUFC_ECOLI pepstats swissprot:SUFC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SUFC_ECOLI pepwheel swissprot:SUFC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SUFC_ECOLI pepwindow swissprot:SUFC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SUFC_ECOLI sigcleave swissprot:SUFC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SUFC_ECOLI ## Database ID URL or Descriptions # BioGrid 4263182 125 # EcoGene EG11035 tsx # FUNCTION TSX_ECOLI Constitutes the receptor for colicin K and phage T6, and functions as substrate-specific channel for nucleosides and deoxynucleosides. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_component GO:0046930 pore complex; IDA:EcoCyc. # GO_function GO:0015471 nucleoside-specific channel forming porin activity; IDA:EcoCyc. # GO_process GO:0006811 ion transport; IEA:UniProtKB-KW. # GO_process GO:0015858 nucleoside transport; IDA:EcoCyc. # GO_process GO:0046718 viral entry into host cell; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043234 protein complex # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # Gene3D 2.40.230.20 -; 1. # InterPro IPR003055 Channel_Tsx # InterPro IPR018013 Channel_Tsx-like # KEGG_Brite ko02000 Transporters # Organism TSX_ECOLI Escherichia coli (strain K12) # PATRIC 32115971 VBIEscCol129921_0427 # PDB 1TLW X-ray; 3.10 A; A/B=23-294 # PDB 1TLY X-ray; 3.01 A; A/B=23-294 # PDB 1TLZ X-ray; 3.10 A; A/B=23-294 # PIR JQ0798 JQ0798 # PRINTS PR01277 CHANNELTSX # Pfam PF03502 Channel_Tsx # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TSX_ECOLI Nucleoside-specific channel-forming protein tsx # RefSeq NP_414945 NC_000913.3 # RefSeq WP_001295328 NZ_LN832404.1 # SUBCELLULAR LOCATION TSX_ECOLI Cell outer membrane; Multi-pass membrane protein. # SUPFAM SSF111364 SSF111364 # TCDB 1.B.10.1 the nucleoside-specific channel-forming outer membrane porin (tsx) family # eggNOG COG3248 LUCA # eggNOG ENOG4105DRB Bacteria BLAST swissprot:TSX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TSX_ECOLI BioCyc ECOL316407:JW0401-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0401-MONOMER BioCyc EcoCyc:EG11035-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11035-MONOMER BioCyc MetaCyc:EG11035-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11035-MONOMER COG COG3248 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3248 DOI 10.1007/BF00259416 http://dx.doi.org/10.1007/BF00259416 DOI 10.1016/0378-1119(90)90341-N http://dx.doi.org/10.1016/0378-1119(90)90341-N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M57685 http://www.ebi.ac.uk/ena/data/view/M57685 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EchoBASE EB1028 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1028 EcoGene EG11035 http://www.ecogene.org/geneInfo.php?eg_id=EG11035 EnsemblBacteria AAC73514 http://www.ensemblgenomes.org/id/AAC73514 EnsemblBacteria AAC73514 http://www.ensemblgenomes.org/id/AAC73514 EnsemblBacteria BAE76191 http://www.ensemblgenomes.org/id/BAE76191 EnsemblBacteria BAE76191 http://www.ensemblgenomes.org/id/BAE76191 EnsemblBacteria BAE76191 http://www.ensemblgenomes.org/id/BAE76191 EnsemblBacteria b0411 http://www.ensemblgenomes.org/id/b0411 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0046930 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046930 GO_function GO:0015471 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015471 GO_process GO:0006811 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811 GO_process GO:0015858 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015858 GO_process GO:0046718 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046718 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 2.40.230.20 http://www.cathdb.info/version/latest/superfamily/2.40.230.20 GeneID 946242 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946242 HOGENOM HOG000273630 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000273630&db=HOGENOM6 InterPro IPR003055 http://www.ebi.ac.uk/interpro/entry/IPR003055 InterPro IPR018013 http://www.ebi.ac.uk/interpro/entry/IPR018013 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0401 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0401 KEGG_Gene eco:b0411 http://www.genome.jp/dbget-bin/www_bget?eco:b0411 KEGG_Orthology KO:K05517 http://www.genome.jp/dbget-bin/www_bget?KO:K05517 OMA KSTGWGY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KSTGWGY PDB 1TLW http://www.ebi.ac.uk/pdbe-srv/view/entry/1TLW PDB 1TLY http://www.ebi.ac.uk/pdbe-srv/view/entry/1TLY PDB 1TLZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1TLZ PDBsum 1TLW http://www.ebi.ac.uk/pdbsum/1TLW PDBsum 1TLY http://www.ebi.ac.uk/pdbsum/1TLY PDBsum 1TLZ http://www.ebi.ac.uk/pdbsum/1TLZ PRINTS PR01277 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01277 PSORT swissprot:TSX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TSX_ECOLI PSORT-B swissprot:TSX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TSX_ECOLI PSORT2 swissprot:TSX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TSX_ECOLI Pfam PF03502 http://pfam.xfam.org/family/PF03502 Phobius swissprot:TSX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TSX_ECOLI ProteinModelPortal P0A927 http://www.proteinmodelportal.org/query/uniprot/P0A927 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2199819 http://www.ncbi.nlm.nih.gov/pubmed/2199819 PubMed 2265760 http://www.ncbi.nlm.nih.gov/pubmed/2265760 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414945 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414945 RefSeq WP_001295328 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295328 SMR P0A927 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A927 STRING 511145.b0411 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0411&targetmode=cogs STRING COG3248 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3248&targetmode=cogs SUPFAM SSF111364 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF111364 TCDB 1.B.10.1 http://www.tcdb.org/search/result.php?tc=1.B.10.1 UniProtKB TSX_ECOLI http://www.uniprot.org/uniprot/TSX_ECOLI UniProtKB-AC P0A927 http://www.uniprot.org/uniprot/P0A927 charge swissprot:TSX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TSX_ECOLI eggNOG COG3248 http://eggnogapi.embl.de/nog_data/html/tree/COG3248 eggNOG ENOG4105DRB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DRB epestfind swissprot:TSX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TSX_ECOLI garnier swissprot:TSX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TSX_ECOLI helixturnhelix swissprot:TSX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TSX_ECOLI hmoment swissprot:TSX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TSX_ECOLI iep swissprot:TSX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TSX_ECOLI inforesidue swissprot:TSX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TSX_ECOLI octanol swissprot:TSX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TSX_ECOLI pepcoil swissprot:TSX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TSX_ECOLI pepdigest swissprot:TSX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TSX_ECOLI pepinfo swissprot:TSX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TSX_ECOLI pepnet swissprot:TSX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TSX_ECOLI pepstats swissprot:TSX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TSX_ECOLI pepwheel swissprot:TSX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TSX_ECOLI pepwindow swissprot:TSX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TSX_ECOLI sigcleave swissprot:TSX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TSX_ECOLI ## Database ID URL or Descriptions # BioGrid 4259651 17 # EcoGene EG13733 ydbL # InterPro IPR008309 UCP025560 # Organism YDBL_ECOLI Escherichia coli (strain K12) # PATRIC 32118052 VBIEscCol129921_1446 # PIR B64889 B64889 # PIRSF PIRSF025560 UCP025560 # Pfam PF07027 DUF1318 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDBL_ECOLI Uncharacterized protein YdbL # RefSeq NP_415901 NC_000913.3 # RefSeq WP_001300734 NZ_LN832404.1 # eggNOG COG3784 LUCA # eggNOG ENOG4105WXT Bacteria BLAST swissprot:YDBL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDBL_ECOLI BioCyc ECOL316407:JW5216-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5216-MONOMER BioCyc EcoCyc:G6705-MONOMER http://biocyc.org/getid?id=EcoCyc:G6705-MONOMER COG COG3784 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3784 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3497 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3497 EcoGene EG13733 http://www.ecogene.org/geneInfo.php?eg_id=EG13733 EnsemblBacteria AAC74465 http://www.ensemblgenomes.org/id/AAC74465 EnsemblBacteria AAC74465 http://www.ensemblgenomes.org/id/AAC74465 EnsemblBacteria BAE76421 http://www.ensemblgenomes.org/id/BAE76421 EnsemblBacteria BAE76421 http://www.ensemblgenomes.org/id/BAE76421 EnsemblBacteria BAE76421 http://www.ensemblgenomes.org/id/BAE76421 EnsemblBacteria b1383 http://www.ensemblgenomes.org/id/b1383 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945943 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945943 HOGENOM HOG000291224 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000291224&db=HOGENOM6 InParanoid P76076 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76076 InterPro IPR008309 http://www.ebi.ac.uk/interpro/entry/IPR008309 KEGG_Gene ecj:JW5216 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5216 KEGG_Gene eco:b1383 http://www.genome.jp/dbget-bin/www_bget?eco:b1383 KEGG_Orthology KO:K09978 http://www.genome.jp/dbget-bin/www_bget?KO:K09978 OMA EQPNGYL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EQPNGYL PSORT swissprot:YDBL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDBL_ECOLI PSORT-B swissprot:YDBL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDBL_ECOLI PSORT2 swissprot:YDBL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDBL_ECOLI Pfam PF07027 http://pfam.xfam.org/family/PF07027 Phobius swissprot:YDBL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDBL_ECOLI ProteinModelPortal P76076 http://www.proteinmodelportal.org/query/uniprot/P76076 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415901 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415901 RefSeq WP_001300734 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300734 STRING 511145.b1383 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1383&targetmode=cogs STRING COG3784 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3784&targetmode=cogs UniProtKB YDBL_ECOLI http://www.uniprot.org/uniprot/YDBL_ECOLI UniProtKB-AC P76076 http://www.uniprot.org/uniprot/P76076 charge swissprot:YDBL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDBL_ECOLI eggNOG COG3784 http://eggnogapi.embl.de/nog_data/html/tree/COG3784 eggNOG ENOG4105WXT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105WXT epestfind swissprot:YDBL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDBL_ECOLI garnier swissprot:YDBL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDBL_ECOLI helixturnhelix swissprot:YDBL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDBL_ECOLI hmoment swissprot:YDBL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDBL_ECOLI iep swissprot:YDBL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDBL_ECOLI inforesidue swissprot:YDBL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDBL_ECOLI octanol swissprot:YDBL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDBL_ECOLI pepcoil swissprot:YDBL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDBL_ECOLI pepdigest swissprot:YDBL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDBL_ECOLI pepinfo swissprot:YDBL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDBL_ECOLI pepnet swissprot:YDBL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDBL_ECOLI pepstats swissprot:YDBL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDBL_ECOLI pepwheel swissprot:YDBL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDBL_ECOLI pepwindow swissprot:YDBL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDBL_ECOLI sigcleave swissprot:YDBL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDBL_ECOLI ## Database ID URL or Descriptions # AltName YDFE_ECOLI ORF6 # BioGrid 4260249 13 # CAUTION Could be the product of a pseudogene. The original protein is truncated by an IS2 element which is inserted after residue 255, giving an altered C-terminus. {ECO 0000305}. # EcoGene EG11304 ydfE # IntAct Q47138 4 # Organism YDFE_ECOLI Escherichia coli (strain K12) # PATRIC 48662468 VBIEscCol107702_1594 # PIR S03698 S03698 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDFE_ECOLI Putative uncharacterized protein YdfE BLAST swissprot:YDFE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDFE_ECOLI BioCyc ECOL316407:JW1568-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1568-MONOMER BioCyc EcoCyc:EG11304-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11304-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1111/j.1365-2958.1989.tb00249.x http://dx.doi.org/10.1111/j.1365-2958.1989.tb00249.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X07465 http://www.ebi.ac.uk/ena/data/view/X07465 EchoBASE EB1281 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1281 EcoGene EG11304 http://www.ecogene.org/geneInfo.php?eg_id=EG11304 EnsemblBacteria BAA15281 http://www.ensemblgenomes.org/id/BAA15281 EnsemblBacteria BAA15281 http://www.ensemblgenomes.org/id/BAA15281 EnsemblBacteria BAA15281 http://www.ensemblgenomes.org/id/BAA15281 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv HOGENOM HOG000202503 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000202503&db=HOGENOM6 IntAct Q47138 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q47138* KEGG_Gene ecj:JW1568 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1568 OMA ELAYGRC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ELAYGRC PSORT swissprot:YDFE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDFE_ECOLI PSORT-B swissprot:YDFE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDFE_ECOLI PSORT2 swissprot:YDFE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDFE_ECOLI Phobius swissprot:YDFE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDFE_ECOLI ProteinModelPortal Q47138 http://www.proteinmodelportal.org/query/uniprot/Q47138 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2477663 http://www.ncbi.nlm.nih.gov/pubmed/2477663 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SMR Q47138 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q47138 STRING 316407.85675028 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85675028&targetmode=cogs UniProtKB YDFE_ECOLI http://www.uniprot.org/uniprot/YDFE_ECOLI UniProtKB-AC Q47138 http://www.uniprot.org/uniprot/Q47138 charge swissprot:YDFE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDFE_ECOLI epestfind swissprot:YDFE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDFE_ECOLI garnier swissprot:YDFE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDFE_ECOLI helixturnhelix swissprot:YDFE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDFE_ECOLI hmoment swissprot:YDFE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDFE_ECOLI iep swissprot:YDFE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDFE_ECOLI inforesidue swissprot:YDFE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDFE_ECOLI octanol swissprot:YDFE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDFE_ECOLI pepcoil swissprot:YDFE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDFE_ECOLI pepdigest swissprot:YDFE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDFE_ECOLI pepinfo swissprot:YDFE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDFE_ECOLI pepnet swissprot:YDFE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDFE_ECOLI pepstats swissprot:YDFE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDFE_ECOLI pepwheel swissprot:YDFE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDFE_ECOLI pepwindow swissprot:YDFE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDFE_ECOLI sigcleave swissprot:YDFE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDFE_ECOLI ## Database ID URL or Descriptions # BioGrid 4260583 8 # EcoGene EG12311 iscX # FUNCTION ISCX_ECOLI May function as iron donor in the assembly of iron- sulfur clusters. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004857 enzyme inhibitor activity; IDA:EcoCyc. # GO_function GO:0005506 iron ion binding; IDA:EcoCyc. # GO_function GO:0008198 ferrous iron binding; IDA:EcoCyc. # GO_process GO:0016226 iron-sulfur cluster assembly; IGI:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0030234 enzyme regulator activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 1.10.10.600 -; 1. # IntAct P0C0L9 5 # InterPro IPR007479 ISC_FeS_clus_asmbl_IscsX # Organism ISCX_ECOLI Escherichia coli (strain K12) # PATRIC 32120443 VBIEscCol129921_2624 # PDB 1UJ8 X-ray; 1.75 A; A=2-66 # PDB 2BZT NMR; -; A=1-66 # PIR C65029 C65029 # PIRSF PIRSF039003 IscX # Pfam PF04384 Fe-S_assembly # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ISCX_ECOLI Protein IscX # RefSeq NP_417019 NC_000913.3 # RefSeq WP_000523616 NZ_LN832404.1 # SIMILARITY Belongs to the IscX family. {ECO 0000305}. # SUBUNIT Monomer. {ECO:0000269|PubMed 15937904}. # SUPFAM SSF140319 SSF140319 # TIGRFAMs TIGR03412 iscX_yfhJ # eggNOG COG2975 LUCA # eggNOG ENOG4105WVQ Bacteria BLAST swissprot:ISCX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ISCX_ECOLI BioCyc ECOL316407:JW2508-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2508-MONOMER BioCyc EcoCyc:EG12311-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12311-MONOMER DIP DIP-48188N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48188N DOI 10.1002/prot.20481 http://dx.doi.org/10.1002/prot.20481 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M88654 http://www.ebi.ac.uk/ena/data/view/M88654 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U01827 http://www.ebi.ac.uk/ena/data/view/U01827 EchoBASE EB2217 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2217 EcoGene EG12311 http://www.ecogene.org/geneInfo.php?eg_id=EG12311 EnsemblBacteria AAC75577 http://www.ensemblgenomes.org/id/AAC75577 EnsemblBacteria AAC75577 http://www.ensemblgenomes.org/id/AAC75577 EnsemblBacteria BAA16414 http://www.ensemblgenomes.org/id/BAA16414 EnsemblBacteria BAA16414 http://www.ensemblgenomes.org/id/BAA16414 EnsemblBacteria BAA16414 http://www.ensemblgenomes.org/id/BAA16414 EnsemblBacteria b2524 http://www.ensemblgenomes.org/id/b2524 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004857 GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0008198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008198 GO_process GO:0016226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016226 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 1.10.10.600 http://www.cathdb.info/version/latest/superfamily/1.10.10.600 GeneID 945196 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945196 HOGENOM HOG000262066 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000262066&db=HOGENOM6 InParanoid P0C0L9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0C0L9 IntAct P0C0L9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0C0L9* InterPro IPR007479 http://www.ebi.ac.uk/interpro/entry/IPR007479 KEGG_Gene ecj:JW2508 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2508 KEGG_Gene eco:b2524 http://www.genome.jp/dbget-bin/www_bget?eco:b2524 OMA AIQQAWI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AIQQAWI PDB 1UJ8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1UJ8 PDB 2BZT http://www.ebi.ac.uk/pdbe-srv/view/entry/2BZT PDBsum 1UJ8 http://www.ebi.ac.uk/pdbsum/1UJ8 PDBsum 2BZT http://www.ebi.ac.uk/pdbsum/2BZT PSORT swissprot:ISCX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ISCX_ECOLI PSORT-B swissprot:ISCX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ISCX_ECOLI PSORT2 swissprot:ISCX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ISCX_ECOLI Pfam PF04384 http://pfam.xfam.org/family/PF04384 Phobius swissprot:ISCX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ISCX_ECOLI PhylomeDB P0C0L9 http://phylomedb.org/?seqid=P0C0L9 ProteinModelPortal P0C0L9 http://www.proteinmodelportal.org/query/uniprot/P0C0L9 PubMed 1317854 http://www.ncbi.nlm.nih.gov/pubmed/1317854 PubMed 15937904 http://www.ncbi.nlm.nih.gov/pubmed/15937904 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8300516 http://www.ncbi.nlm.nih.gov/pubmed/8300516 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417019 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417019 RefSeq WP_000523616 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000523616 SMR P0C0L9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0C0L9 STRING 511145.b2524 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2524&targetmode=cogs SUPFAM SSF140319 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF140319 TIGRFAMs TIGR03412 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03412 UniProtKB ISCX_ECOLI http://www.uniprot.org/uniprot/ISCX_ECOLI UniProtKB-AC P0C0L9 http://www.uniprot.org/uniprot/P0C0L9 charge swissprot:ISCX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ISCX_ECOLI eggNOG COG2975 http://eggnogapi.embl.de/nog_data/html/tree/COG2975 eggNOG ENOG4105WVQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105WVQ epestfind swissprot:ISCX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ISCX_ECOLI garnier swissprot:ISCX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ISCX_ECOLI helixturnhelix swissprot:ISCX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ISCX_ECOLI hmoment swissprot:ISCX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ISCX_ECOLI iep swissprot:ISCX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ISCX_ECOLI inforesidue swissprot:ISCX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ISCX_ECOLI octanol swissprot:ISCX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ISCX_ECOLI pepcoil swissprot:ISCX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ISCX_ECOLI pepdigest swissprot:ISCX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ISCX_ECOLI pepinfo swissprot:ISCX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ISCX_ECOLI pepnet swissprot:ISCX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ISCX_ECOLI pepstats swissprot:ISCX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ISCX_ECOLI pepwheel swissprot:ISCX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ISCX_ECOLI pepwindow swissprot:ISCX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ISCX_ECOLI sigcleave swissprot:ISCX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ISCX_ECOLI ## Database ID URL or Descriptions # BioGrid 4262581 5 # CDD cd06174 MFS # ENZYME REGULATION Reaction is unaffected by the ionophores valinomycin, valinomycin plus nigericin, and carbonyl cyanide p- trifluoromethoxyphenylhydrazone (FCCP). {ECO:0000269|PubMed 3283129}. # EcoGene EG11054 uhpT # FUNCTION UHPT_ECOLI Mediates the exchange of external hexose 6-phosphate and internal inorganic phosphate. Can transport glucose-6-phosphate, fructose-6-phosphate and mannose-6-phosphate. Also catalyzes the neutral exchange of internal and external phosphate. {ECO 0000269|PubMed 2197272, ECO 0000269|PubMed 3038843, ECO 0000269|PubMed 3283129, ECO 0000269|PubMed 3522583, ECO 0000269|PubMed 5330662, ECO 0000269|PubMed 8402899}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IBA:GO_Central. # GO_function UHPT_ECOLI GO 0015526 hexose-phosphate inorganic phosphate antiporter activity; IDA EcoCyc. # GO_process GO:0008643 carbohydrate transport; IEA:UniProtKB-KW. # GO_process GO:0015712 hexose phosphate transport; IMP:EcoCyc. # GO_process GO:0015760 glucose-6-phosphate transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # INDUCTION UHPT_ECOLI Expression is induced by external glucose-6-phosphate through the UhpABC signaling cascade. {ECO 0000269|PubMed 11739766, ECO 0000269|PubMed 3038843, ECO 0000269|PubMed 4905309, ECO 0000269|PubMed 8999880}. # InterPro IPR000849 Sugar_P_transporter # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # InterPro IPR021159 Sugar-P_transporter_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02020 Two-component system # Organism UHPT_ECOLI Escherichia coli (strain K12) # PATRIC 32122825 VBIEscCol129921_3788 # PIR A30395 MMECHP # PIRSF PIRSF002808 Hexose_phosphate_transp # PROSITE PS00942 GLPT # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Hexose-6-phosphate:phosphate antiporter {ECO 0000305} # RefSeq NP_418122 NC_000913.3 # RefSeq WP_000879194 NZ_LN832404.1 # SIMILARITY Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family. {ECO 0000305}. # SUBCELLULAR LOCATION UHPT_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 2156798, ECO 0000269|PubMed 8402899}; Multi-pass membrane protein {ECO 0000255, ECO 0000269|PubMed 2156798}. # SUBUNIT Monomer. {ECO:0000269|PubMed 2197272}. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.4 the major facilitator superfamily (mfs) # eggNOG COG2271 LUCA # eggNOG ENOG4105CXY Bacteria BLAST swissprot:UHPT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UHPT_ECOLI BioCyc ECOL316407:JW3641-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3641-MONOMER BioCyc EcoCyc:UHPT-MONOMER http://biocyc.org/getid?id=EcoCyc:UHPT-MONOMER BioCyc MetaCyc:UHPT-MONOMER http://biocyc.org/getid?id=MetaCyc:UHPT-MONOMER COG COG2271 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2271 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1016/S0092-8674(05)80082-0 http://dx.doi.org/10.1016/S0092-8674(05)80082-0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.272.3.1910 http://dx.doi.org/10.1074/jbc.272.3.1910 DOI 10.1099/00221287-147-12-3345 http://dx.doi.org/10.1099/00221287-147-12-3345 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M17102 http://www.ebi.ac.uk/ena/data/view/M17102 EMBL M89479 http://www.ebi.ac.uk/ena/data/view/M89479 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1047 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1047 EcoGene EG11054 http://www.ecogene.org/geneInfo.php?eg_id=EG11054 EnsemblBacteria AAC76689 http://www.ensemblgenomes.org/id/AAC76689 EnsemblBacteria AAC76689 http://www.ensemblgenomes.org/id/AAC76689 EnsemblBacteria BAE77627 http://www.ensemblgenomes.org/id/BAE77627 EnsemblBacteria BAE77627 http://www.ensemblgenomes.org/id/BAE77627 EnsemblBacteria BAE77627 http://www.ensemblgenomes.org/id/BAE77627 EnsemblBacteria b3666 http://www.ensemblgenomes.org/id/b3666 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015526 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015526 GO_process GO:0008643 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008643 GO_process GO:0015712 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015712 GO_process GO:0015760 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015760 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948201 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948201 HOGENOM HOG000274728 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000274728&db=HOGENOM6 InParanoid P0AGC0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGC0 InterPro IPR000849 http://www.ebi.ac.uk/interpro/entry/IPR000849 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 InterPro IPR021159 http://www.ebi.ac.uk/interpro/entry/IPR021159 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3641 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3641 KEGG_Gene eco:b3666 http://www.genome.jp/dbget-bin/www_bget?eco:b3666 KEGG_Orthology KO:K07784 http://www.genome.jp/dbget-bin/www_bget?KO:K07784 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA WANIHAF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WANIHAF PROSITE PS00942 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00942 PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:UHPT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UHPT_ECOLI PSORT-B swissprot:UHPT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UHPT_ECOLI PSORT2 swissprot:UHPT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UHPT_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:UHPT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UHPT_ECOLI PhylomeDB P0AGC0 http://phylomedb.org/?seqid=P0AGC0 ProteinModelPortal P0AGC0 http://www.proteinmodelportal.org/query/uniprot/P0AGC0 PubMed 11739766 http://www.ncbi.nlm.nih.gov/pubmed/11739766 PubMed 1569007 http://www.ncbi.nlm.nih.gov/pubmed/1569007 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2156798 http://www.ncbi.nlm.nih.gov/pubmed/2156798 PubMed 2197272 http://www.ncbi.nlm.nih.gov/pubmed/2197272 PubMed 3038843 http://www.ncbi.nlm.nih.gov/pubmed/3038843 PubMed 3283129 http://www.ncbi.nlm.nih.gov/pubmed/3283129 PubMed 3301805 http://www.ncbi.nlm.nih.gov/pubmed/3301805 PubMed 3522583 http://www.ncbi.nlm.nih.gov/pubmed/3522583 PubMed 4905309 http://www.ncbi.nlm.nih.gov/pubmed/4905309 PubMed 5330662 http://www.ncbi.nlm.nih.gov/pubmed/5330662 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 8402899 http://www.ncbi.nlm.nih.gov/pubmed/8402899 PubMed 8999880 http://www.ncbi.nlm.nih.gov/pubmed/8999880 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418122 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418122 RefSeq WP_000879194 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000879194 STRING 511145.b3666 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3666&targetmode=cogs STRING COG2271 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2271&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.4 http://www.tcdb.org/search/result.php?tc=2.A.1.4 UniProtKB UHPT_ECOLI http://www.uniprot.org/uniprot/UHPT_ECOLI UniProtKB-AC P0AGC0 http://www.uniprot.org/uniprot/P0AGC0 charge swissprot:UHPT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UHPT_ECOLI eggNOG COG2271 http://eggnogapi.embl.de/nog_data/html/tree/COG2271 eggNOG ENOG4105CXY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CXY epestfind swissprot:UHPT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UHPT_ECOLI garnier swissprot:UHPT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UHPT_ECOLI helixturnhelix swissprot:UHPT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UHPT_ECOLI hmoment swissprot:UHPT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UHPT_ECOLI iep swissprot:UHPT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UHPT_ECOLI inforesidue swissprot:UHPT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UHPT_ECOLI octanol swissprot:UHPT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UHPT_ECOLI pepcoil swissprot:UHPT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UHPT_ECOLI pepdigest swissprot:UHPT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UHPT_ECOLI pepinfo swissprot:UHPT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UHPT_ECOLI pepnet swissprot:UHPT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UHPT_ECOLI pepstats swissprot:UHPT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UHPT_ECOLI pepwheel swissprot:UHPT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UHPT_ECOLI pepwindow swissprot:UHPT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UHPT_ECOLI sigcleave swissprot:UHPT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UHPT_ECOLI ## Database ID URL or Descriptions # BioGrid 4261423 14 # EcoGene EG10301 fhlA # FUNCTION FHLA_ECOLI Required for induction of expression of the formate dehydrogenase H and hydrogenase-3 structural genes. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0043565 sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0000160 phosphorelay signal transduction system; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.60 -; 1. # Gene3D 3.30.450.40 -; 2. # Gene3D 3.40.50.300 -; 1. # INTERACTION FHLA_ECOLI P0A6F5 groL; NbExp=2; IntAct=EBI-1113147, EBI-543750; # IntAct P19323 4 # InterPro IPR002078 Sigma_54_int # InterPro IPR002197 HTH_Fis # InterPro IPR003018 GAF # InterPro IPR003593 AAA+_ATPase # InterPro IPR009057 Homeodomain-like # InterPro IPR025662 Sigma_54_int_dom_ATP-bd_1 # InterPro IPR025944 Sigma_54_int_dom_CS # InterPro IPR027417 P-loop_NTPase # InterPro IPR029016 GAF_dom-like # KEGG_Brite ko03000 Transcription factors # Organism FHLA_ECOLI Escherichia coli (strain K12) # PATRIC 32120862 VBIEscCol129921_2823 # PIR S12079 S12079 # PRINTS PR01590 HTHFIS # PROSITE PS00675 SIGMA54_INTERACT_1 # PROSITE PS00688 SIGMA54_INTERACT_3 # PROSITE PS50045 SIGMA54_INTERACT_4 # Pfam PF00158 Sigma54_activat # Pfam PF01590 GAF # Pfam PF02954 HTH_8 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FHLA_ECOLI Formate hydrogenlyase transcriptional activator # RefSeq NP_417211 NC_000913.3 # RefSeq WP_001301332 NZ_LN832404.1 # SIMILARITY Contains 1 GAF domain. {ECO 0000305}. # SIMILARITY Contains 1 sigma-54 factor interaction domain. {ECO:0000255|PROSITE-ProRule PRU00193}. # SMART SM00065 GAF; 2 # SMART SM00382 AAA # SUPFAM SSF46689 SSF46689 # SUPFAM SSF52540 SSF52540 # SUPFAM SSF55781 SSF55781; 2 # eggNOG COG3604 LUCA # eggNOG ENOG4108JUA Bacteria BLAST swissprot:FHLA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FHLA_ECOLI BioCyc ECOL316407:JW2701-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2701-MONOMER BioCyc EcoCyc:PD02936 http://biocyc.org/getid?id=EcoCyc:PD02936 COG COG3604 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3604 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1990.tb00711.x http://dx.doi.org/10.1111/j.1365-2958.1990.tb00711.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M58504 http://www.ebi.ac.uk/ena/data/view/M58504 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EMBL X52227 http://www.ebi.ac.uk/ena/data/view/X52227 EchoBASE EB0297 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0297 EcoGene EG10301 http://www.ecogene.org/geneInfo.php?eg_id=EG10301 EnsemblBacteria AAC75773 http://www.ensemblgenomes.org/id/AAC75773 EnsemblBacteria AAC75773 http://www.ensemblgenomes.org/id/AAC75773 EnsemblBacteria BAE76808 http://www.ensemblgenomes.org/id/BAE76808 EnsemblBacteria BAE76808 http://www.ensemblgenomes.org/id/BAE76808 EnsemblBacteria BAE76808 http://www.ensemblgenomes.org/id/BAE76808 EnsemblBacteria b2731 http://www.ensemblgenomes.org/id/b2731 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 Gene3D 3.30.450.40 http://www.cathdb.info/version/latest/superfamily/3.30.450.40 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947181 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947181 HOGENOM HOG000058488 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000058488&db=HOGENOM6 InParanoid P19323 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P19323 IntAct P19323 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P19323* InterPro IPR002078 http://www.ebi.ac.uk/interpro/entry/IPR002078 InterPro IPR002197 http://www.ebi.ac.uk/interpro/entry/IPR002197 InterPro IPR003018 http://www.ebi.ac.uk/interpro/entry/IPR003018 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR025662 http://www.ebi.ac.uk/interpro/entry/IPR025662 InterPro IPR025944 http://www.ebi.ac.uk/interpro/entry/IPR025944 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR029016 http://www.ebi.ac.uk/interpro/entry/IPR029016 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW2701 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2701 KEGG_Gene eco:b2731 http://www.genome.jp/dbget-bin/www_bget?eco:b2731 KEGG_Orthology KO:K15836 http://www.genome.jp/dbget-bin/www_bget?KO:K15836 OMA NTMLGVL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NTMLGVL PRINTS PR01590 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01590 PROSITE PS00675 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00675 PROSITE PS00688 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00688 PROSITE PS50045 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50045 PSORT swissprot:FHLA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FHLA_ECOLI PSORT-B swissprot:FHLA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FHLA_ECOLI PSORT2 swissprot:FHLA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FHLA_ECOLI Pfam PF00158 http://pfam.xfam.org/family/PF00158 Pfam PF01590 http://pfam.xfam.org/family/PF01590 Pfam PF02954 http://pfam.xfam.org/family/PF02954 Phobius swissprot:FHLA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FHLA_ECOLI PhylomeDB P19323 http://phylomedb.org/?seqid=P19323 ProteinModelPortal P19323 http://www.proteinmodelportal.org/query/uniprot/P19323 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2118503 http://www.ncbi.nlm.nih.gov/pubmed/2118503 PubMed 2280686 http://www.ncbi.nlm.nih.gov/pubmed/2280686 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417211 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417211 RefSeq WP_001301332 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001301332 SMART SM00065 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00065 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P19323 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P19323 STRING 511145.b2731 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2731&targetmode=cogs STRING COG3604 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3604&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SUPFAM SSF55781 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55781 UniProtKB FHLA_ECOLI http://www.uniprot.org/uniprot/FHLA_ECOLI UniProtKB-AC P19323 http://www.uniprot.org/uniprot/P19323 charge swissprot:FHLA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FHLA_ECOLI eggNOG COG3604 http://eggnogapi.embl.de/nog_data/html/tree/COG3604 eggNOG ENOG4108JUA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108JUA epestfind swissprot:FHLA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FHLA_ECOLI garnier swissprot:FHLA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FHLA_ECOLI helixturnhelix swissprot:FHLA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FHLA_ECOLI hmoment swissprot:FHLA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FHLA_ECOLI iep swissprot:FHLA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FHLA_ECOLI inforesidue swissprot:FHLA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FHLA_ECOLI octanol swissprot:FHLA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FHLA_ECOLI pepcoil swissprot:FHLA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FHLA_ECOLI pepdigest swissprot:FHLA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FHLA_ECOLI pepinfo swissprot:FHLA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FHLA_ECOLI pepnet swissprot:FHLA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FHLA_ECOLI pepstats swissprot:FHLA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FHLA_ECOLI pepwheel swissprot:FHLA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FHLA_ECOLI pepwindow swissprot:FHLA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FHLA_ECOLI sigcleave swissprot:FHLA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FHLA_ECOLI ## Database ID URL or Descriptions # AltName TDCB_ECOLI L-serine dehydratase # AltName TDCB_ECOLI Threonine deaminase # BIOPHYSICOCHEMICAL PROPERTIES TDCB_ECOLI Kinetic parameters KM=0.30 uM for L-threonine (at 37 dregrees Celsius and at pH 7.8) {ECO 0000269|PubMed 15390404}; KM=0.35 uM for L-serine (at 37 dregrees Celsius and at pH 7.8) {ECO 0000269|PubMed 15390404}; # BioGrid 4262419 9 # CATALYTIC ACTIVITY TDCB_ECOLI L-serine = pyruvate + NH(3). # CATALYTIC ACTIVITY TDCB_ECOLI L-threonine = 2-oxobutanoate + NH(3). # COFACTOR TDCB_ECOLI Name=pyridoxal 5'-phosphate; Xref=ChEBI CHEBI 597326; Evidence={ECO 0000269|PubMed 5321308}; # ENZYME REGULATION TDCB_ECOLI Each protein molecule can bind up to four molecules of AMP, which act as an allosteric activator to the enzyme. The enzyme is also inhibited by alpha-keto acids and other catabolites. {ECO 0000269|PubMed 13405870, ECO 0000269|PubMed 15390404}. # EcoGene EG10990 tdcB # FUNCTION TDCB_ECOLI Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. TdcB also dehydrates serine to yield pyruvate via analogous enamine/imine intermediates. {ECO 0000269|PubMed 10388709, ECO 0000269|PubMed 13405870, ECO 0000269|PubMed 15390404}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000166 nucleotide binding; IEA:UniProtKB-KW. # GO_function GO:0003941 L-serine ammonia-lyase activity; IDA:EcoCyc. # GO_function GO:0004793 threonine aldolase activity; IDA:EcoliWiki. # GO_function GO:0004794 L-threonine ammonia-lyase activity; IDA:EcoCyc. # GO_function GO:0016597 amino acid binding; IDA:EcoliWiki. # GO_function GO:0030170 pyridoxal phosphate binding; IDA:EcoliWiki. # GO_process GO:0006565 L-serine catabolic process; IDA:EcoCyc. # GO_process GO:0006567 threonine catabolic process; IDA:EcoCyc. # GO_process GO:0070689 L-threonine catabolic process to propionate; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009056 catabolic process # INDUCTION In the absence of glucose and oxygen,. {ECO:0000269|PubMed 13405870}. # IntAct P0AGF6 3 # InterPro IPR000634 Ser/Thr_deHydtase_PyrdxlP-BS # InterPro IPR001926 TrpB-like_PLP-dep # InterPro IPR005789 Thr_deHydtase_catblc # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00260 Glycine, serine and threonine metabolism # KEGG_Pathway ko00290 Valine, leucine and isoleucine biosynthesis # Organism TDCB_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid degradation; L-threonine degradation via propanoate pathway; propanoate from L-threonine step 1/4. # PATRIC 32121650 VBIEscCol129921_3211 # PIR A26367 DWECTD # PROSITE PS00165 DEHYDRATASE_SER_THR # Pfam PF00291 PALP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TDCB_ECOLI L-threonine dehydratase catabolic TdcB # RefSeq NP_417587 NC_000913.3 # RefSeq WP_000548347 NZ_LN832404.1 # SIMILARITY Belongs to the serine/threonine dehydratase family. {ECO 0000305}. # SUBUNIT In the native structure, TdcB is in a dimeric form, whereas in the TdcB-AMP complex, it exists in a tetrameric form (dimer of dimers). {ECO 0000250}. # SUPFAM SSF53686 SSF53686 # TIGRFAMs TIGR01127 ilvA_1Cterm # UniPathway UPA00052 UER00507 # eggNOG COG1171 LUCA # eggNOG ENOG4105C7B Bacteria BLAST swissprot:TDCB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TDCB_ECOLI BioCyc ECOL316407:JW3088-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3088-MONOMER BioCyc EcoCyc:THREDEHYDCAT-MONOMER http://biocyc.org/getid?id=EcoCyc:THREDEHYDCAT-MONOMER BioCyc MetaCyc:THREDEHYDCAT-MONOMER http://biocyc.org/getid?id=MetaCyc:THREDEHYDCAT-MONOMER COG COG1171 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1171 DIP DIP-48063N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48063N DOI 10.1007/s12038-007-0121-1 http://dx.doi.org/10.1007/s12038-007-0121-1 DOI 10.1016/0167-4838(82)90371-5 http://dx.doi.org/10.1016/0167-4838(82)90371-5 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.84.2.393 http://dx.doi.org/10.1073/pnas.84.2.393 DOI 10.1093/nar/17.10.3994 http://dx.doi.org/10.1093/nar/17.10.3994 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.3.1.17 http://www.genome.jp/dbget-bin/www_bget?EC:4.3.1.17 EC_number EC:4.3.1.19 http://www.genome.jp/dbget-bin/www_bget?EC:4.3.1.19 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M21312 http://www.ebi.ac.uk/ena/data/view/M21312 EMBL M23638 http://www.ebi.ac.uk/ena/data/view/M23638 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X14430 http://www.ebi.ac.uk/ena/data/view/X14430 ENZYME 4.3.1.17 http://enzyme.expasy.org/EC/4.3.1.17 ENZYME 4.3.1.19 http://enzyme.expasy.org/EC/4.3.1.19 EchoBASE EB0983 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0983 EcoGene EG10990 http://www.ecogene.org/geneInfo.php?eg_id=EG10990 EnsemblBacteria AAC76152 http://www.ensemblgenomes.org/id/AAC76152 EnsemblBacteria AAC76152 http://www.ensemblgenomes.org/id/AAC76152 EnsemblBacteria BAE77166 http://www.ensemblgenomes.org/id/BAE77166 EnsemblBacteria BAE77166 http://www.ensemblgenomes.org/id/BAE77166 EnsemblBacteria BAE77166 http://www.ensemblgenomes.org/id/BAE77166 EnsemblBacteria b3117 http://www.ensemblgenomes.org/id/b3117 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000166 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000166 GO_function GO:0003941 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003941 GO_function GO:0004793 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004793 GO_function GO:0004794 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004794 GO_function GO:0016597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016597 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_process GO:0006565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006565 GO_process GO:0006567 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006567 GO_process GO:0070689 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070689 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GeneID 947633 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947633 HOGENOM HOG000046972 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000046972&db=HOGENOM6 InParanoid P0AGF6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGF6 IntAct P0AGF6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AGF6* IntEnz 4.3.1.17 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.3.1.17 IntEnz 4.3.1.19 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.3.1.19 InterPro IPR000634 http://www.ebi.ac.uk/interpro/entry/IPR000634 InterPro IPR001926 http://www.ebi.ac.uk/interpro/entry/IPR001926 InterPro IPR005789 http://www.ebi.ac.uk/interpro/entry/IPR005789 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3088 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3088 KEGG_Gene eco:b3117 http://www.genome.jp/dbget-bin/www_bget?eco:b3117 KEGG_Orthology KO:K01754 http://www.genome.jp/dbget-bin/www_bget?KO:K01754 KEGG_Pathway ko00260 http://www.genome.jp/kegg-bin/show_pathway?ko00260 KEGG_Pathway ko00290 http://www.genome.jp/kegg-bin/show_pathway?ko00290 KEGG_Reaction rn:R00220 http://www.genome.jp/dbget-bin/www_bget?rn:R00220 KEGG_Reaction rn:R00996 http://www.genome.jp/dbget-bin/www_bget?rn:R00996 OMA NPTINII http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NPTINII PROSITE PS00165 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00165 PSORT swissprot:TDCB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TDCB_ECOLI PSORT-B swissprot:TDCB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TDCB_ECOLI PSORT2 swissprot:TDCB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TDCB_ECOLI Pfam PF00291 http://pfam.xfam.org/family/PF00291 Phobius swissprot:TDCB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TDCB_ECOLI PhylomeDB P0AGF6 http://phylomedb.org/?seqid=P0AGF6 ProteinModelPortal P0AGF6 http://www.proteinmodelportal.org/query/uniprot/P0AGF6 PubMed 10388709 http://www.ncbi.nlm.nih.gov/pubmed/10388709 PubMed 13405870 http://www.ncbi.nlm.nih.gov/pubmed/13405870 PubMed 15390404 http://www.ncbi.nlm.nih.gov/pubmed/15390404 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17954980 http://www.ncbi.nlm.nih.gov/pubmed/17954980 PubMed 2660107 http://www.ncbi.nlm.nih.gov/pubmed/2660107 PubMed 3053659 http://www.ncbi.nlm.nih.gov/pubmed/3053659 PubMed 3540965 http://www.ncbi.nlm.nih.gov/pubmed/3540965 PubMed 5321308 http://www.ncbi.nlm.nih.gov/pubmed/5321308 PubMed 6751404 http://www.ncbi.nlm.nih.gov/pubmed/6751404 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417587 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417587 RefSeq WP_000548347 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000548347 SMR P0AGF6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AGF6 STRING 511145.b3117 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3117&targetmode=cogs STRING COG1171 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1171&targetmode=cogs SUPFAM SSF53686 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53686 TIGRFAMs TIGR01127 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01127 UniProtKB TDCB_ECOLI http://www.uniprot.org/uniprot/TDCB_ECOLI UniProtKB-AC P0AGF6 http://www.uniprot.org/uniprot/P0AGF6 charge swissprot:TDCB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TDCB_ECOLI eggNOG COG1171 http://eggnogapi.embl.de/nog_data/html/tree/COG1171 eggNOG ENOG4105C7B http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C7B epestfind swissprot:TDCB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TDCB_ECOLI garnier swissprot:TDCB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TDCB_ECOLI helixturnhelix swissprot:TDCB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TDCB_ECOLI hmoment swissprot:TDCB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TDCB_ECOLI iep swissprot:TDCB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TDCB_ECOLI inforesidue swissprot:TDCB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TDCB_ECOLI octanol swissprot:TDCB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TDCB_ECOLI pepcoil swissprot:TDCB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TDCB_ECOLI pepdigest swissprot:TDCB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TDCB_ECOLI pepinfo swissprot:TDCB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TDCB_ECOLI pepnet swissprot:TDCB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TDCB_ECOLI pepstats swissprot:TDCB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TDCB_ECOLI pepwheel swissprot:TDCB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TDCB_ECOLI pepwindow swissprot:TDCB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TDCB_ECOLI sigcleave swissprot:TDCB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TDCB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260617 238 # CDD cd07185 OmpA_C-like # EcoGene EG11152 yfiB # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0009279 cell outer membrane; IEA:InterPro. # GO_component GO:0016021 integral component of membrane; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # Gene3D 3.30.1330.60 -; 1. # InterPro IPR006664 OMP_bac # InterPro IPR006665 OmpA-like # Organism YFIB_ECOLI Escherichia coli (strain K12) # PATRIC 32120609 VBIEscCol129921_2703 # PIR H65038 H65038 # PRINTS PR01021 OMPADOMAIN # PROSITE PS51123 OMPA_2 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF00691 OmpA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFIB_ECOLI Putative lipoprotein YfiB # RefSeq NP_417096 NC_000913.3 # RefSeq WP_000589847 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA25961.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the OmpA family. {ECO 0000305}. # SIMILARITY Contains 1 OmpA-like domain. {ECO:0000255|PROSITE- ProRule PRU00473}. # SUBCELLULAR LOCATION YFIB_ECOLI Cell membrane {ECO 0000255|PROSITE- ProRule PRU00303}; Lipid-anchor {ECO 0000255|PROSITE- ProRule PRU00303}. # SUPFAM SSF103088 SSF103088 # TCDB 1.B.6.1.21 the ompa-ompf porin (oop) family # eggNOG COG2885 LUCA # eggNOG ENOG41090EK Bacteria BLAST swissprot:YFIB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFIB_ECOLI BioCyc ECOL316407:JW2586-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2586-MONOMER BioCyc EcoCyc:EG11152-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11152-MONOMER DIP DIP-12056N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12056N DOI 10.1007/BF00330047 http://dx.doi.org/10.1007/BF00330047 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X01818 http://www.ebi.ac.uk/ena/data/view/X01818 EchoBASE EB1141 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1141 EcoGene EG11152 http://www.ecogene.org/geneInfo.php?eg_id=EG11152 EnsemblBacteria AAC75654 http://www.ensemblgenomes.org/id/AAC75654 EnsemblBacteria AAC75654 http://www.ensemblgenomes.org/id/AAC75654 EnsemblBacteria BAA16490 http://www.ensemblgenomes.org/id/BAA16490 EnsemblBacteria BAA16490 http://www.ensemblgenomes.org/id/BAA16490 EnsemblBacteria BAA16490 http://www.ensemblgenomes.org/id/BAA16490 EnsemblBacteria b2605 http://www.ensemblgenomes.org/id/b2605 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 Gene3D 3.30.1330.60 http://www.cathdb.info/version/latest/superfamily/3.30.1330.60 GeneID 947094 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947094 HOGENOM HOG000189913 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000189913&db=HOGENOM6 InParanoid P07021 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P07021 IntAct P07021 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P07021* InterPro IPR006664 http://www.ebi.ac.uk/interpro/entry/IPR006664 InterPro IPR006665 http://www.ebi.ac.uk/interpro/entry/IPR006665 KEGG_Gene ecj:JW2586 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2586 KEGG_Gene eco:b2605 http://www.genome.jp/dbget-bin/www_bget?eco:b2605 MINT MINT-1275809 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1275809 OMA TDEGWAY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TDEGWAY PRINTS PR01021 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01021 PROSITE PS51123 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51123 PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YFIB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFIB_ECOLI PSORT-B swissprot:YFIB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFIB_ECOLI PSORT2 swissprot:YFIB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFIB_ECOLI Pfam PF00691 http://pfam.xfam.org/family/PF00691 Phobius swissprot:YFIB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFIB_ECOLI PhylomeDB P07021 http://phylomedb.org/?seqid=P07021 ProteinModelPortal P07021 http://www.proteinmodelportal.org/query/uniprot/P07021 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6298574 http://www.ncbi.nlm.nih.gov/pubmed/6298574 PubMed 6357787 http://www.ncbi.nlm.nih.gov/pubmed/6357787 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417096 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417096 RefSeq WP_000589847 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000589847 SMR P07021 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P07021 STRING 511145.b2605 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2605&targetmode=cogs SUPFAM SSF103088 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103088 TCDB 1.B.6.1.21 http://www.tcdb.org/search/result.php?tc=1.B.6.1.21 UniProtKB YFIB_ECOLI http://www.uniprot.org/uniprot/YFIB_ECOLI UniProtKB-AC P07021 http://www.uniprot.org/uniprot/P07021 charge swissprot:YFIB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFIB_ECOLI eggNOG COG2885 http://eggnogapi.embl.de/nog_data/html/tree/COG2885 eggNOG ENOG41090EK http://eggnogapi.embl.de/nog_data/html/tree/ENOG41090EK epestfind swissprot:YFIB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFIB_ECOLI garnier swissprot:YFIB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFIB_ECOLI helixturnhelix swissprot:YFIB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFIB_ECOLI hmoment swissprot:YFIB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFIB_ECOLI iep swissprot:YFIB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFIB_ECOLI inforesidue swissprot:YFIB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFIB_ECOLI octanol swissprot:YFIB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFIB_ECOLI pepcoil swissprot:YFIB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFIB_ECOLI pepdigest swissprot:YFIB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFIB_ECOLI pepinfo swissprot:YFIB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFIB_ECOLI pepnet swissprot:YFIB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFIB_ECOLI pepstats swissprot:YFIB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFIB_ECOLI pepwheel swissprot:YFIB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFIB_ECOLI pepwindow swissprot:YFIB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFIB_ECOLI sigcleave swissprot:YFIB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFIB_ECOLI ## Database ID URL or Descriptions # BioGrid 4261398 8 # EcoGene EG13244 ybaP # IntAct P77301 12 # InterPro IPR002816 Pheromone_shutdown_TraB # Organism YBAP_ECOLI Escherichia coli (strain K12) # PATRIC 32116121 VBIEscCol129921_0502 # PIR A64779 A64779 # Pfam PF01963 TraB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBAP_ECOLI Uncharacterized protein YbaP # RefSeq NP_415015 NC_000913.3 # RefSeq WP_000365173 NZ_LN832404.1 # eggNOG COG3735 LUCA # eggNOG ENOG4105MBR Bacteria BLAST swissprot:YBAP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBAP_ECOLI BioCyc ECOL316407:JW0471-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0471-MONOMER BioCyc EcoCyc:G6258-MONOMER http://biocyc.org/getid?id=EcoCyc:G6258-MONOMER COG COG3735 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3735 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EchoBASE EB3033 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3033 EcoGene EG13244 http://www.ecogene.org/geneInfo.php?eg_id=EG13244 EnsemblBacteria AAC73584 http://www.ensemblgenomes.org/id/AAC73584 EnsemblBacteria AAC73584 http://www.ensemblgenomes.org/id/AAC73584 EnsemblBacteria BAE76261 http://www.ensemblgenomes.org/id/BAE76261 EnsemblBacteria BAE76261 http://www.ensemblgenomes.org/id/BAE76261 EnsemblBacteria BAE76261 http://www.ensemblgenomes.org/id/BAE76261 EnsemblBacteria b0482 http://www.ensemblgenomes.org/id/b0482 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945124 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945124 HOGENOM HOG000117687 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117687&db=HOGENOM6 InParanoid P77301 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77301 IntAct P77301 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77301* InterPro IPR002816 http://www.ebi.ac.uk/interpro/entry/IPR002816 KEGG_Gene ecj:JW0471 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0471 KEGG_Gene eco:b0482 http://www.genome.jp/dbget-bin/www_bget?eco:b0482 KEGG_Orthology KO:K09973 http://www.genome.jp/dbget-bin/www_bget?KO:K09973 OMA LQTMISW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LQTMISW PSORT swissprot:YBAP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBAP_ECOLI PSORT-B swissprot:YBAP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBAP_ECOLI PSORT2 swissprot:YBAP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBAP_ECOLI Pfam PF01963 http://pfam.xfam.org/family/PF01963 Phobius swissprot:YBAP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBAP_ECOLI ProteinModelPortal P77301 http://www.proteinmodelportal.org/query/uniprot/P77301 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415015 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415015 RefSeq WP_000365173 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000365173 SMR P77301 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77301 STRING 511145.b0482 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0482&targetmode=cogs STRING COG3735 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3735&targetmode=cogs UniProtKB YBAP_ECOLI http://www.uniprot.org/uniprot/YBAP_ECOLI UniProtKB-AC P77301 http://www.uniprot.org/uniprot/P77301 charge swissprot:YBAP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBAP_ECOLI eggNOG COG3735 http://eggnogapi.embl.de/nog_data/html/tree/COG3735 eggNOG ENOG4105MBR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105MBR epestfind swissprot:YBAP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBAP_ECOLI garnier swissprot:YBAP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBAP_ECOLI helixturnhelix swissprot:YBAP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBAP_ECOLI hmoment swissprot:YBAP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBAP_ECOLI iep swissprot:YBAP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBAP_ECOLI inforesidue swissprot:YBAP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBAP_ECOLI octanol swissprot:YBAP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBAP_ECOLI pepcoil swissprot:YBAP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBAP_ECOLI pepdigest swissprot:YBAP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBAP_ECOLI pepinfo swissprot:YBAP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBAP_ECOLI pepnet swissprot:YBAP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBAP_ECOLI pepstats swissprot:YBAP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBAP_ECOLI pepwheel swissprot:YBAP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBAP_ECOLI pepwindow swissprot:YBAP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBAP_ECOLI sigcleave swissprot:YBAP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBAP_ECOLI ## Database ID URL or Descriptions # BioGrid 4261200 107 # CDD cd03019 DsbA_DsbA # DISRUPTION PHENOTYPE Induction of the PhoP/PhoQ two-component regulatory system, suppressed by 50 uM CuSO(4). {ECO:0000269|PubMed 22267510}. # EcoGene EG11297 dsbA # FUNCTION DSBA_ECOLI Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. Required for pilus biogenesis. PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing (deletion of dsbA/dsbB, treatment with dithiothreitol). MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway. {ECO 0000269|PubMed 1429594, ECO 0000269|PubMed 22267510}. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0003756 protein disulfide isomerase activity; IDA:EcoliWiki. # GO_function GO:0015035 protein disulfide oxidoreductase activity; IDA:EcoCyc. # GO_process GO:0045454 cell redox homeostasis; IEA:InterPro. # GO_process GO:0071236 cellular response to antibiotic; IMP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0042592 homeostatic process # Gene3D 3.40.30.10 -; 2. # INTERACTION DSBA_ECOLI P0A6M2 dsbB; NbExp=5; IntAct=EBI-549711, EBI-1170740; P00634 phoA; NbExp=2; IntAct=EBI-549711, EBI-552958; # IntAct P0AEG4 19 # InterPro IPR001853 DSBA-like_thioredoxin_dom # InterPro IPR012336 Thioredoxin-like_fold # InterPro IPR013766 Thioredoxin_domain # InterPro IPR017937 Thioredoxin_CS # InterPro IPR023205 DsbA/DsbL # KEGG_Brite ko03110 Chaperones and folding catalysts # Organism DSBA_ECOLI Escherichia coli (strain K12) # PATRIC 32123217 VBIEscCol129921_3969 # PDB 1A23 NMR; -; A=20-208 # PDB 1A24 NMR; -; A=20-208 # PDB 1A2J X-ray; 2.00 A; A=20-208 # PDB 1A2L X-ray; 2.70 A; A/B=20-208 # PDB 1A2M X-ray; 2.70 A; A/B=20-208 # PDB 1AC1 X-ray; 2.00 A; A/B=20-208 # PDB 1ACV X-ray; 1.90 A; A/B=20-208 # PDB 1BQ7 X-ray; 2.80 A; A/B/C/D/E/F=20-208 # PDB 1DSB X-ray; 2.00 A; A/B=20-208 # PDB 1FVJ X-ray; 2.06 A; A/B=20-208 # PDB 1FVK X-ray; 1.70 A; A/B=20-208 # PDB 1TI1 X-ray; 2.60 A; A=20-208 # PDB 1U3A X-ray; 2.00 A; A/B/D/E=20-208 # PDB 1UN2 X-ray; 2.40 A; A=20-118 # PDB 2B3S X-ray; 1.96 A; A/B=20-208 # PDB 2B6M X-ray; 2.65 A; A/B=20-208 # PDB 2HI7 X-ray; 3.70 A; A=20-208 # PDB 2LEG NMR; -; A=20-208 # PDB 2ZUP X-ray; 3.70 A; A=20-208 # PDB 3E9J X-ray; 3.70 A; B/E=20-208 # PDB 4TKY X-ray; 2.50 A; A/B/C/D=20-208 # PDB 4ZIJ X-ray; 1.78 A; A/B=20-207 # PIR A39292 A39292 # PIRSF PIRSF001488 Tdi_protein # PROSITE PS00194 THIOREDOXIN_1 # PROSITE PS51352 THIOREDOXIN_2 # Pfam PF01323 DSBA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Thiol disulfide interchange protein DsbA # RefSeq NP_418297 NC_000913.3 # RefSeq WP_000725337 NZ_LN832404.1 # SIMILARITY Belongs to the thioredoxin family. DsbA subfamily. {ECO 0000305}. # SIMILARITY Contains 1 thioredoxin domain. {ECO:0000255|PROSITE- ProRule PRU00691}. # SUBCELLULAR LOCATION DSBA_ECOLI Periplasm. # SUPFAM SSF52833 SSF52833 # eggNOG COG0526 LUCA # eggNOG ENOG4108Z33 Bacteria BLAST swissprot:DSBA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DSBA_ECOLI BioCyc ECOL316407:JW3832-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3832-MONOMER BioCyc EcoCyc:DISULFOXRED-MONOMER http://biocyc.org/getid?id=EcoCyc:DISULFOXRED-MONOMER BioCyc MetaCyc:DISULFOXRED-MONOMER http://biocyc.org/getid?id=MetaCyc:DISULFOXRED-MONOMER COG COG0526 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0526 DIP DIP-35886N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35886N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1002/pro.5560060603 http://dx.doi.org/10.1002/pro.5560060603 DOI 10.1002/pro.5560060910 http://dx.doi.org/10.1002/pro.5560060910 DOI 10.1006/jmbi.1998.1726 http://dx.doi.org/10.1006/jmbi.1998.1726 DOI 10.1016/0092-8674(91)90532-4 http://dx.doi.org/10.1016/0092-8674(91)90532-4 DOI 10.1016/0092-8674(95)90210-4 http://dx.doi.org/10.1016/0092-8674(95)90210-4 DOI 10.1016/S0969-2126(98)00077-X http://dx.doi.org/10.1016/S0969-2126(98)00077-X DOI 10.1016/j.jmb.2005.01.049 http://dx.doi.org/10.1016/j.jmb.2005.01.049 DOI 10.1021/bi00070a016 http://dx.doi.org/10.1021/bi00070a016 DOI 10.1021/bi980136y http://dx.doi.org/10.1021/bi980136y DOI 10.1038/365464a0 http://dx.doi.org/10.1038/365464a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1110/ps.8.1.96 http://dx.doi.org/10.1110/ps.8.1.96 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.06055-11 http://dx.doi.org/10.1128/JB.06055-11 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL M77746 http://www.ebi.ac.uk/ena/data/view/M77746 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U35662 http://www.ebi.ac.uk/ena/data/view/U35662 EMBL U35817 http://www.ebi.ac.uk/ena/data/view/U35817 EMBL U35818 http://www.ebi.ac.uk/ena/data/view/U35818 EMBL U35819 http://www.ebi.ac.uk/ena/data/view/U35819 EMBL U35820 http://www.ebi.ac.uk/ena/data/view/U35820 EMBL U35821 http://www.ebi.ac.uk/ena/data/view/U35821 EMBL U35822 http://www.ebi.ac.uk/ena/data/view/U35822 EMBL U35823 http://www.ebi.ac.uk/ena/data/view/U35823 EMBL U35824 http://www.ebi.ac.uk/ena/data/view/U35824 EMBL U35825 http://www.ebi.ac.uk/ena/data/view/U35825 EMBL U36828 http://www.ebi.ac.uk/ena/data/view/U36828 EMBL U36829 http://www.ebi.ac.uk/ena/data/view/U36829 EMBL U36830 http://www.ebi.ac.uk/ena/data/view/U36830 EMBL U36831 http://www.ebi.ac.uk/ena/data/view/U36831 EMBL U36832 http://www.ebi.ac.uk/ena/data/view/U36832 EMBL U36833 http://www.ebi.ac.uk/ena/data/view/U36833 EMBL U36834 http://www.ebi.ac.uk/ena/data/view/U36834 EMBL U36835 http://www.ebi.ac.uk/ena/data/view/U36835 EMBL X63186 http://www.ebi.ac.uk/ena/data/view/X63186 EMBL X80762 http://www.ebi.ac.uk/ena/data/view/X80762 EchoBASE EB1274 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1274 EcoGene EG11297 http://www.ecogene.org/geneInfo.php?eg_id=EG11297 EnsemblBacteria AAC76858 http://www.ensemblgenomes.org/id/AAC76858 EnsemblBacteria AAC76858 http://www.ensemblgenomes.org/id/AAC76858 EnsemblBacteria BAE77448 http://www.ensemblgenomes.org/id/BAE77448 EnsemblBacteria BAE77448 http://www.ensemblgenomes.org/id/BAE77448 EnsemblBacteria BAE77448 http://www.ensemblgenomes.org/id/BAE77448 EnsemblBacteria b3860 http://www.ensemblgenomes.org/id/b3860 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0003756 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003756 GO_function GO:0015035 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015035 GO_process GO:0045454 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045454 GO_process GO:0071236 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071236 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 Gene3D 3.40.30.10 http://www.cathdb.info/version/latest/superfamily/3.40.30.10 GeneID 948353 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948353 HOGENOM HOG000265316 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000265316&db=HOGENOM6 InParanoid P0AEG4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEG4 IntAct P0AEG4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEG4* InterPro IPR001853 http://www.ebi.ac.uk/interpro/entry/IPR001853 InterPro IPR012336 http://www.ebi.ac.uk/interpro/entry/IPR012336 InterPro IPR013766 http://www.ebi.ac.uk/interpro/entry/IPR013766 InterPro IPR017937 http://www.ebi.ac.uk/interpro/entry/IPR017937 InterPro IPR023205 http://www.ebi.ac.uk/interpro/entry/IPR023205 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW3832 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3832 KEGG_Gene eco:b3860 http://www.genome.jp/dbget-bin/www_bget?eco:b3860 KEGG_Orthology KO:K03673 http://www.genome.jp/dbget-bin/www_bget?KO:K03673 MINT MINT-1247943 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1247943 OMA DKVSPLM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DKVSPLM PDB 1A23 http://www.ebi.ac.uk/pdbe-srv/view/entry/1A23 PDB 1A24 http://www.ebi.ac.uk/pdbe-srv/view/entry/1A24 PDB 1A2J http://www.ebi.ac.uk/pdbe-srv/view/entry/1A2J PDB 1A2L http://www.ebi.ac.uk/pdbe-srv/view/entry/1A2L PDB 1A2M http://www.ebi.ac.uk/pdbe-srv/view/entry/1A2M PDB 1AC1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1AC1 PDB 1ACV http://www.ebi.ac.uk/pdbe-srv/view/entry/1ACV PDB 1BQ7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1BQ7 PDB 1DSB http://www.ebi.ac.uk/pdbe-srv/view/entry/1DSB PDB 1FVJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1FVJ PDB 1FVK http://www.ebi.ac.uk/pdbe-srv/view/entry/1FVK PDB 1TI1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1TI1 PDB 1U3A http://www.ebi.ac.uk/pdbe-srv/view/entry/1U3A PDB 1UN2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1UN2 PDB 2B3S http://www.ebi.ac.uk/pdbe-srv/view/entry/2B3S PDB 2B6M http://www.ebi.ac.uk/pdbe-srv/view/entry/2B6M PDB 2HI7 http://www.ebi.ac.uk/pdbe-srv/view/entry/2HI7 PDB 2LEG http://www.ebi.ac.uk/pdbe-srv/view/entry/2LEG PDB 2ZUP http://www.ebi.ac.uk/pdbe-srv/view/entry/2ZUP PDB 3E9J http://www.ebi.ac.uk/pdbe-srv/view/entry/3E9J PDB 4TKY http://www.ebi.ac.uk/pdbe-srv/view/entry/4TKY PDB 4ZIJ http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZIJ PDBsum 1A23 http://www.ebi.ac.uk/pdbsum/1A23 PDBsum 1A24 http://www.ebi.ac.uk/pdbsum/1A24 PDBsum 1A2J http://www.ebi.ac.uk/pdbsum/1A2J PDBsum 1A2L http://www.ebi.ac.uk/pdbsum/1A2L PDBsum 1A2M http://www.ebi.ac.uk/pdbsum/1A2M PDBsum 1AC1 http://www.ebi.ac.uk/pdbsum/1AC1 PDBsum 1ACV http://www.ebi.ac.uk/pdbsum/1ACV PDBsum 1BQ7 http://www.ebi.ac.uk/pdbsum/1BQ7 PDBsum 1DSB http://www.ebi.ac.uk/pdbsum/1DSB PDBsum 1FVJ http://www.ebi.ac.uk/pdbsum/1FVJ PDBsum 1FVK http://www.ebi.ac.uk/pdbsum/1FVK PDBsum 1TI1 http://www.ebi.ac.uk/pdbsum/1TI1 PDBsum 1U3A http://www.ebi.ac.uk/pdbsum/1U3A PDBsum 1UN2 http://www.ebi.ac.uk/pdbsum/1UN2 PDBsum 2B3S http://www.ebi.ac.uk/pdbsum/2B3S PDBsum 2B6M http://www.ebi.ac.uk/pdbsum/2B6M PDBsum 2HI7 http://www.ebi.ac.uk/pdbsum/2HI7 PDBsum 2LEG http://www.ebi.ac.uk/pdbsum/2LEG PDBsum 2ZUP http://www.ebi.ac.uk/pdbsum/2ZUP PDBsum 3E9J http://www.ebi.ac.uk/pdbsum/3E9J PDBsum 4TKY http://www.ebi.ac.uk/pdbsum/4TKY PDBsum 4ZIJ http://www.ebi.ac.uk/pdbsum/4ZIJ PROSITE PS00194 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00194 PROSITE PS51352 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51352 PSORT swissprot:DSBA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DSBA_ECOLI PSORT-B swissprot:DSBA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DSBA_ECOLI PSORT2 swissprot:DSBA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DSBA_ECOLI Pfam PF01323 http://pfam.xfam.org/family/PF01323 Phobius swissprot:DSBA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DSBA_ECOLI PhylomeDB P0AEG4 http://phylomedb.org/?seqid=P0AEG4 ProteinModelPortal P0AEG4 http://www.proteinmodelportal.org/query/uniprot/P0AEG4 PubMed 10210188 http://www.ncbi.nlm.nih.gov/pubmed/10210188 PubMed 1429594 http://www.ncbi.nlm.nih.gov/pubmed/1429594 PubMed 15755450 http://www.ncbi.nlm.nih.gov/pubmed/15755450 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1740115 http://www.ncbi.nlm.nih.gov/pubmed/1740115 PubMed 1934062 http://www.ncbi.nlm.nih.gov/pubmed/1934062 PubMed 22267510 http://www.ncbi.nlm.nih.gov/pubmed/22267510 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 8413591 http://www.ncbi.nlm.nih.gov/pubmed/8413591 PubMed 8494885 http://www.ncbi.nlm.nih.gov/pubmed/8494885 PubMed 8521518 http://www.ncbi.nlm.nih.gov/pubmed/8521518 PubMed 9194175 http://www.ncbi.nlm.nih.gov/pubmed/9194175 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9300489 http://www.ncbi.nlm.nih.gov/pubmed/9300489 PubMed 9572841 http://www.ncbi.nlm.nih.gov/pubmed/9572841 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 PubMed 9655827 http://www.ncbi.nlm.nih.gov/pubmed/9655827 RefSeq NP_418297 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418297 RefSeq WP_000725337 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000725337 SMR P0AEG4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEG4 STRING 511145.b3860 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3860&targetmode=cogs STRING COG0526 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0526&targetmode=cogs SUPFAM SSF52833 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52833 SWISS-2DPAGE P0AEG4 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AEG4 UniProtKB DSBA_ECOLI http://www.uniprot.org/uniprot/DSBA_ECOLI UniProtKB-AC P0AEG4 http://www.uniprot.org/uniprot/P0AEG4 charge swissprot:DSBA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DSBA_ECOLI eggNOG COG0526 http://eggnogapi.embl.de/nog_data/html/tree/COG0526 eggNOG ENOG4108Z33 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Z33 epestfind swissprot:DSBA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DSBA_ECOLI garnier swissprot:DSBA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DSBA_ECOLI helixturnhelix swissprot:DSBA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DSBA_ECOLI hmoment swissprot:DSBA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DSBA_ECOLI iep swissprot:DSBA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DSBA_ECOLI inforesidue swissprot:DSBA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DSBA_ECOLI octanol swissprot:DSBA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DSBA_ECOLI pepcoil swissprot:DSBA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DSBA_ECOLI pepdigest swissprot:DSBA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DSBA_ECOLI pepinfo swissprot:DSBA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DSBA_ECOLI pepnet swissprot:DSBA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DSBA_ECOLI pepstats swissprot:DSBA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DSBA_ECOLI pepwheel swissprot:DSBA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DSBA_ECOLI pepwindow swissprot:DSBA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DSBA_ECOLI sigcleave swissprot:DSBA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DSBA_ECOLI ## Database ID URL or Descriptions # ALTERNATIVE PRODUCTS CHEA_ECOLI Event=Alternative initiation; Named isoforms=2; Name=cheA(L); Synonyms=long, large; IsoId=P07363-1; Sequence=Displayed; Name=cheA(S); Synonyms=short; IsoId=P07363-2; Sequence=VSP_018886; # BRENDA 2.7.13 2026 # BioGrid 4261034 200 # CATALYTIC ACTIVITY CHEA_ECOLI ATP + protein L-histidine = ADP + protein N- phospho-L-histidine. # DOMAIN CHEA_ECOLI May have three functional domains one for interaction with CheB and CheY, a second for regulating phosphorylation and controlling the stability of the protein, and a third for receiving input signals regulating CheA activity. {ECO 0000269|PubMed 2832069}. # EcoGene EG10146 cheA # FUNCTION CHEA_ECOLI Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY. # GO_component GO:0005737 cytoplasm; IDA:EcoCyc. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_function GO:0000155 phosphorelay sensor kinase activity; IEA:InterPro. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0000160 phosphorelay signal transduction system; IDA:EcoliWiki. # GO_process GO:0006935 chemotaxis; IMP:EcoCyc. # GO_process GO:0016310 phosphorylation; IDA:EcoliWiki. # GO_process GO:0031400 negative regulation of protein modification process; IDA:CACAO. # GO_process GO:0035307 positive regulation of protein dephosphorylation; IMP:EcoCyc. # GO_process GO:0046777 protein autophosphorylation; IDA:EcoliWiki. # GO_process GO:0051649 establishment of localization in cell; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0040011 locomotion # Gene3D 1.10.287.560 -; 1. # Gene3D 1.20.120.160 -; 1. # Gene3D 3.30.565.10 -; 1. # Gene3D 3.30.70.400 -; 1. # INTERACTION CHEA_ECOLI P0AE67 cheY; NbExp=3; IntAct=EBI-1026773, EBI-546693; P0A9H9 cheZ; NbExp=3; IntAct=EBI-1026773, EBI-546726; # IntAct P07363 33 # InterPro IPR002545 CheW # InterPro IPR003594 HATPase_C # InterPro IPR003661 HisK_dim/P # InterPro IPR004105 CheA-like_dim # InterPro IPR004358 Sig_transdc_His_kin-like_C # InterPro IPR005467 His_kinase_dom # InterPro IPR008207 Sig_transdc_His_kin_Hpt_dom # InterPro IPR015162 CheY-binding # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01001 Protein kinases # KEGG_Brite ko02022 M00506 CheA-CheYBV (chemotaxis) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Brite ko02030 M00506 CheA-CheYBV (chemotaxis) two-component regulatory system # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Brite ko02035 M00506 CheA-CheYBV (chemotaxis) two-component regulatory system # KEGG_Pathway ko02020 Two-component system # KEGG_Pathway ko02030 Bacterial chemotaxis # Organism CHEA_ECOLI Escherichia coli (strain K12) # PATRIC 32119103 VBIEscCol129921_1969 # PDB 1A0O X-ray; 2.95 A; B/D/F/H=124-257 # PDB 1EAY X-ray; 2.00 A; C/D=156-228 # PDB 1FFG X-ray; 2.10 A; B/D=124-257 # PDB 1FFS X-ray; 2.40 A; B/D=124-257 # PDB 1FFW X-ray; 2.70 A; B/D=124-257 # PDB 1FWP NMR; -; A=124-262 # PDB 2LP4 NMR; -; A=1-225 # PIR H64951 QRECCS # PRINTS PR00344 BCTRLSENSOR # PROSITE PS50109 HIS_KIN # PROSITE PS50851 CHEW # PROSITE PS50894 HPT # Pfam PF01584 CheW # Pfam PF01627 Hpt # Pfam PF02518 HATPase_c # Pfam PF02895 H-kinase_dim # Pfam PF09078 CheY-binding # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CHEA_ECOLI Chemotaxis protein CheA # RefSeq NP_416402 NC_000913.3 # SIMILARITY Contains 1 HPt domain. {ECO:0000255|PROSITE- ProRule PRU00110}. # SIMILARITY Contains 1 cheW-like domain. {ECO:0000255|PROSITE- ProRule PRU00052}. # SIMILARITY Contains 1 histidine kinase domain. {ECO:0000255|PROSITE-ProRule PRU00107}. # SMART SM00073 HPT # SMART SM00260 CheW # SMART SM00387 HATPase_c # SMART SM01231 H-kinase_dim # SUBCELLULAR LOCATION CHEA_ECOLI Cytoplasm. # SUBUNIT CHEA_ECOLI An in vitro complex of CheW/CheA(L)/CheA(S) in a 1 1 1 ratio increases the autophosphorylation of CheA and is required for the binding of CheY, the phosphorylation substrate. This complex accounts for 10% of the total number of molecules. {ECO 0000269|PubMed 2068106}. # SUPFAM SSF47226 SSF47226 # SUPFAM SSF47384 SSF47384 # SUPFAM SSF50341 SSF50341 # SUPFAM SSF55052 SSF55052 # SUPFAM SSF55874 SSF55874 # eggNOG COG0643 LUCA # eggNOG ENOG4105CBS Bacteria BLAST swissprot:CHEA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CHEA_ECOLI BioCyc ECOL316407:JW1877-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1877-MONOMER BioCyc EcoCyc:CHEA-SMALL http://biocyc.org/getid?id=EcoCyc:CHEA-SMALL BioCyc EcoCyc:PROTEIN-CHEA http://biocyc.org/getid?id=EcoCyc:PROTEIN-CHEA COG COG0643 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0643 DIP DIP-6053N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-6053N DOI 10.1016/0092-8674(88)90490-4 http://dx.doi.org/10.1016/0092-8674(88)90490-4 DOI 10.1021/bi951960e http://dx.doi.org/10.1021/bi951960e DOI 10.1021/bi952707h http://dx.doi.org/10.1021/bi952707h DOI 10.1021/bi961663p http://dx.doi.org/10.1021/bi961663p DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb0198-25 http://dx.doi.org/10.1038/nsb0198-25 DOI 10.1073/pnas.88.14.6269 http://dx.doi.org/10.1073/pnas.88.14.6269 DOI 10.1073/pnas.95.13.7333 http://dx.doi.org/10.1073/pnas.95.13.7333 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DisProt DP00407 http://www.disprot.org/protein.php?id=DP00407 EC_number EC:2.7.13.3 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.13.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M13462 http://www.ebi.ac.uk/ena/data/view/M13462 EMBL M34669 http://www.ebi.ac.uk/ena/data/view/M34669 EMBL M34669 http://www.ebi.ac.uk/ena/data/view/M34669 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.13.3 http://enzyme.expasy.org/EC/2.7.13.3 EchoBASE EB0144 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0144 EcoGene EG10146 http://www.ecogene.org/geneInfo.php?eg_id=EG10146 EnsemblBacteria AAC74958 http://www.ensemblgenomes.org/id/AAC74958 EnsemblBacteria AAC74958 http://www.ensemblgenomes.org/id/AAC74958 EnsemblBacteria BAA15709 http://www.ensemblgenomes.org/id/BAA15709 EnsemblBacteria BAA15709 http://www.ensemblgenomes.org/id/BAA15709 EnsemblBacteria BAA15709 http://www.ensemblgenomes.org/id/BAA15709 EnsemblBacteria b1888 http://www.ensemblgenomes.org/id/b1888 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0000155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000155 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006935 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006935 GO_process GO:0016310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016310 GO_process GO:0031400 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031400 GO_process GO:0035307 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035307 GO_process GO:0046777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046777 GO_process GO:0051649 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051649 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0040011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011 Gene3D 1.10.287.560 http://www.cathdb.info/version/latest/superfamily/1.10.287.560 Gene3D 1.20.120.160 http://www.cathdb.info/version/latest/superfamily/1.20.120.160 Gene3D 3.30.565.10 http://www.cathdb.info/version/latest/superfamily/3.30.565.10 Gene3D 3.30.70.400 http://www.cathdb.info/version/latest/superfamily/3.30.70.400 GeneID 946401 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946401 HOGENOM HOG000255263 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000255263&db=HOGENOM6 InParanoid P07363 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P07363 IntAct P07363 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P07363* IntEnz 2.7.13.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.13.3 InterPro IPR002545 http://www.ebi.ac.uk/interpro/entry/IPR002545 InterPro IPR003594 http://www.ebi.ac.uk/interpro/entry/IPR003594 InterPro IPR003661 http://www.ebi.ac.uk/interpro/entry/IPR003661 InterPro IPR004105 http://www.ebi.ac.uk/interpro/entry/IPR004105 InterPro IPR004358 http://www.ebi.ac.uk/interpro/entry/IPR004358 InterPro IPR005467 http://www.ebi.ac.uk/interpro/entry/IPR005467 InterPro IPR008207 http://www.ebi.ac.uk/interpro/entry/IPR008207 InterPro IPR015162 http://www.ebi.ac.uk/interpro/entry/IPR015162 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01001 http://www.genome.jp/dbget-bin/www_bget?ko01001 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02030 http://www.genome.jp/dbget-bin/www_bget?ko02030 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW1877 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1877 KEGG_Gene eco:b1888 http://www.genome.jp/dbget-bin/www_bget?eco:b1888 KEGG_Orthology KO:K03407 http://www.genome.jp/dbget-bin/www_bget?KO:K03407 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 KEGG_Pathway ko02030 http://www.genome.jp/kegg-bin/show_pathway?ko02030 MINT MINT-1312842 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1312842 OMA HEDSGYK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HEDSGYK PDB 1A0O http://www.ebi.ac.uk/pdbe-srv/view/entry/1A0O PDB 1EAY http://www.ebi.ac.uk/pdbe-srv/view/entry/1EAY PDB 1FFG http://www.ebi.ac.uk/pdbe-srv/view/entry/1FFG PDB 1FFS http://www.ebi.ac.uk/pdbe-srv/view/entry/1FFS PDB 1FFW http://www.ebi.ac.uk/pdbe-srv/view/entry/1FFW PDB 1FWP http://www.ebi.ac.uk/pdbe-srv/view/entry/1FWP PDB 2LP4 http://www.ebi.ac.uk/pdbe-srv/view/entry/2LP4 PDBsum 1A0O http://www.ebi.ac.uk/pdbsum/1A0O PDBsum 1EAY http://www.ebi.ac.uk/pdbsum/1EAY PDBsum 1FFG http://www.ebi.ac.uk/pdbsum/1FFG PDBsum 1FFS http://www.ebi.ac.uk/pdbsum/1FFS PDBsum 1FFW http://www.ebi.ac.uk/pdbsum/1FFW PDBsum 1FWP http://www.ebi.ac.uk/pdbsum/1FWP PDBsum 2LP4 http://www.ebi.ac.uk/pdbsum/2LP4 PRINTS PR00344 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00344 PROSITE PS50109 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50109 PROSITE PS50851 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50851 PROSITE PS50894 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50894 PSORT swissprot:CHEA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CHEA_ECOLI PSORT-B swissprot:CHEA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CHEA_ECOLI PSORT2 swissprot:CHEA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CHEA_ECOLI Pfam PF01584 http://pfam.xfam.org/family/PF01584 Pfam PF01627 http://pfam.xfam.org/family/PF01627 Pfam PF02518 http://pfam.xfam.org/family/PF02518 Pfam PF02895 http://pfam.xfam.org/family/PF02895 Pfam PF09078 http://pfam.xfam.org/family/PF09078 Phobius swissprot:CHEA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CHEA_ECOLI PhylomeDB P07363 http://phylomedb.org/?seqid=P07363 ProteinModelPortal P07363 http://www.proteinmodelportal.org/query/uniprot/P07363 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2002011 http://www.ncbi.nlm.nih.gov/pubmed/2002011 PubMed 2068106 http://www.ncbi.nlm.nih.gov/pubmed/2068106 PubMed 2832069 http://www.ncbi.nlm.nih.gov/pubmed/2832069 PubMed 3510184 http://www.ncbi.nlm.nih.gov/pubmed/3510184 PubMed 8555213 http://www.ncbi.nlm.nih.gov/pubmed/8555213 PubMed 8639521 http://www.ncbi.nlm.nih.gov/pubmed/8639521 PubMed 9020767 http://www.ncbi.nlm.nih.gov/pubmed/9020767 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9437425 http://www.ncbi.nlm.nih.gov/pubmed/9437425 PubMed 9636149 http://www.ncbi.nlm.nih.gov/pubmed/9636149 RefSeq NP_416402 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416402 SMART SM00073 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00073 SMART SM00260 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00260 SMART SM00387 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00387 SMART SM01231 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01231 SMR P07363 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P07363 STRING 511145.b1888 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1888&targetmode=cogs STRING COG0643 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0643&targetmode=cogs SUPFAM SSF47226 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47226 SUPFAM SSF47384 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47384 SUPFAM SSF50341 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50341 SUPFAM SSF55052 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55052 SUPFAM SSF55874 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55874 UniProtKB CHEA_ECOLI http://www.uniprot.org/uniprot/CHEA_ECOLI UniProtKB-AC P07363 http://www.uniprot.org/uniprot/P07363 charge swissprot:CHEA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CHEA_ECOLI eggNOG COG0643 http://eggnogapi.embl.de/nog_data/html/tree/COG0643 eggNOG ENOG4105CBS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CBS epestfind swissprot:CHEA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CHEA_ECOLI garnier swissprot:CHEA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CHEA_ECOLI helixturnhelix swissprot:CHEA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CHEA_ECOLI hmoment swissprot:CHEA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CHEA_ECOLI iep swissprot:CHEA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CHEA_ECOLI inforesidue swissprot:CHEA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CHEA_ECOLI octanol swissprot:CHEA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CHEA_ECOLI pepcoil swissprot:CHEA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CHEA_ECOLI pepdigest swissprot:CHEA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CHEA_ECOLI pepinfo swissprot:CHEA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CHEA_ECOLI pepnet swissprot:CHEA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CHEA_ECOLI pepstats swissprot:CHEA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CHEA_ECOLI pepwheel swissprot:CHEA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CHEA_ECOLI pepwindow swissprot:CHEA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CHEA_ECOLI sigcleave swissprot:CHEA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CHEA_ECOLI ## Database ID URL or Descriptions # ESTHER ecoli-yuar AlphaBeta_hydrolase # GO_function GO:0016787 hydrolase activity; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # Gene3D 3.40.50.1820 -; 3. # InterPro IPR000073 AB_hydrolase_1 # InterPro IPR029058 AB_hydrolase # Organism YUAR_ECOLI Escherichia coli (strain K12) # PIR B36944 B36944 # Pfam PF00561 Abhydrolase_1 # RecName YUAR_ECOLI Putative hydrolase YuaR # RefSeq NP_061409 NC_002483.1 # RefSeq WP_010892530 NZ_CP014273.1 # SIMILARITY Belongs to the peptidase S33 family. {ECO 0000305}. # SIMILARITY Contains 1 AB hydrolase-1 (Alpha/Beta hydrolase fold 1) domain. {ECO 0000255}. # SUPFAM SSF53474 SSF53474; 3 BLAST swissprot:YUAR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YUAR_ECOLI EC_number EC:3.4.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.4.-.- EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL X74278 http://www.ebi.ac.uk/ena/data/view/X74278 ENZYME 3.4.-.- http://enzyme.expasy.org/EC/3.4.-.- G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016787 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016787 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 Gene3D 3.40.50.1820 http://www.cathdb.info/version/latest/superfamily/3.40.50.1820 GeneID 1263517 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263517 IntEnz 3.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4 InterPro IPR000073 http://www.ebi.ac.uk/interpro/entry/IPR000073 InterPro IPR029058 http://www.ebi.ac.uk/interpro/entry/IPR029058 OMA SKPHEIS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SKPHEIS PSORT swissprot:YUAR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YUAR_ECOLI PSORT-B swissprot:YUAR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YUAR_ECOLI PSORT2 swissprot:YUAR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YUAR_ECOLI Pfam PF00561 http://pfam.xfam.org/family/PF00561 Phobius swissprot:YUAR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YUAR_ECOLI PhylomeDB P34211 http://phylomedb.org/?seqid=P34211 ProteinModelPortal P34211 http://www.proteinmodelportal.org/query/uniprot/P34211 PubMed 8288530 http://www.ncbi.nlm.nih.gov/pubmed/8288530 RefSeq NP_061409 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061409 RefSeq WP_010892530 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_010892530 SUPFAM SSF53474 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53474 UniProtKB YUAR_ECOLI http://www.uniprot.org/uniprot/YUAR_ECOLI UniProtKB-AC P34211 http://www.uniprot.org/uniprot/P34211 charge swissprot:YUAR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YUAR_ECOLI epestfind swissprot:YUAR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YUAR_ECOLI garnier swissprot:YUAR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YUAR_ECOLI helixturnhelix swissprot:YUAR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YUAR_ECOLI hmoment swissprot:YUAR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YUAR_ECOLI iep swissprot:YUAR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YUAR_ECOLI inforesidue swissprot:YUAR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YUAR_ECOLI octanol swissprot:YUAR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YUAR_ECOLI pepcoil swissprot:YUAR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YUAR_ECOLI pepdigest swissprot:YUAR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YUAR_ECOLI pepinfo swissprot:YUAR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YUAR_ECOLI pepnet swissprot:YUAR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YUAR_ECOLI pepstats swissprot:YUAR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YUAR_ECOLI pepwheel swissprot:YUAR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YUAR_ECOLI pepwindow swissprot:YUAR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YUAR_ECOLI sigcleave swissprot:YUAR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YUAR_ECOLI ## Database ID URL or Descriptions # BioGrid 4261120 155 # EcoGene EG11798 hofC # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006276 plasmid maintenance; IMP:EcoCyc. # GO_process GO:0015628 protein secretion by the type II secretion system; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0008150 biological_process # GOslim_process GO:0055085 transmembrane transport # InterPro IPR001992 Type_2_secretion_system_CS # InterPro IPR003004 GspF/PilC # InterPro IPR018076 T2SS_F # KEGG_Brite ko02044 Secretion system # Organism HOFC_ECOLI Escherichia coli (strain K12) # PATRIC 32115313 VBIEscCol129921_0108 # PIR B64733 B64733 # PRINTS PR00812 BCTERIALGSPF # PROSITE PS00874 T2SP_F # Pfam PF00482 T2SSF; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HOFC_ECOLI Protein transport protein HofC homolog # RefSeq NP_414648 NC_000913.3 # RefSeq WP_000157266 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=X07917; Type=Frameshift; Positions=Several; Evidence={ECO 0000305}; # SIMILARITY Belongs to the GSP F family. {ECO 0000305}. # SUBCELLULAR LOCATION HOFC_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # eggNOG COG1459 LUCA # eggNOG ENOG4105D7Q Bacteria BLAST swissprot:HOFC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HOFC_ECOLI BioCyc ECOL316407:JW0102-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0102-MONOMER BioCyc EcoCyc:EG11798-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11798-MONOMER COG COG1459 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1459 DOI 10.1016/0378-1119(94)90851-6 http://dx.doi.org/10.1016/0378-1119(94)90851-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2550035 http://dx.doi.org/10.1042/bj2550035 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L28105 http://www.ebi.ac.uk/ena/data/view/L28105 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X07917 http://www.ebi.ac.uk/ena/data/view/X07917 EchoBASE EB1746 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1746 EcoGene EG11798 http://www.ecogene.org/geneInfo.php?eg_id=EG11798 EnsemblBacteria AAC73217 http://www.ensemblgenomes.org/id/AAC73217 EnsemblBacteria AAC73217 http://www.ensemblgenomes.org/id/AAC73217 EnsemblBacteria BAB96674 http://www.ensemblgenomes.org/id/BAB96674 EnsemblBacteria BAB96674 http://www.ensemblgenomes.org/id/BAB96674 EnsemblBacteria BAB96674 http://www.ensemblgenomes.org/id/BAB96674 EnsemblBacteria b0106 http://www.ensemblgenomes.org/id/b0106 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006276 GO_process GO:0015628 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015628 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 945806 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945806 HOGENOM HOG000253740 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000253740&db=HOGENOM6 InParanoid P36646 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P36646 InterPro IPR001992 http://www.ebi.ac.uk/interpro/entry/IPR001992 InterPro IPR003004 http://www.ebi.ac.uk/interpro/entry/IPR003004 InterPro IPR018076 http://www.ebi.ac.uk/interpro/entry/IPR018076 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW0102 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0102 KEGG_Gene eco:b0106 http://www.genome.jp/dbget-bin/www_bget?eco:b0106 KEGG_Orthology KO:K02505 http://www.genome.jp/dbget-bin/www_bget?KO:K02505 OMA MELQMNK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MELQMNK PRINTS PR00812 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00812 PROSITE PS00874 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00874 PSORT swissprot:HOFC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HOFC_ECOLI PSORT-B swissprot:HOFC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HOFC_ECOLI PSORT2 swissprot:HOFC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HOFC_ECOLI Pfam PF00482 http://pfam.xfam.org/family/PF00482 Phobius swissprot:HOFC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HOFC_ECOLI PhylomeDB P36646 http://phylomedb.org/?seqid=P36646 ProteinModelPortal P36646 http://www.proteinmodelportal.org/query/uniprot/P36646 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2904262 http://www.ncbi.nlm.nih.gov/pubmed/2904262 PubMed 7959070 http://www.ncbi.nlm.nih.gov/pubmed/7959070 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414648 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414648 RefSeq WP_000157266 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000157266 SMR P36646 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P36646 STRING 511145.b0106 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0106&targetmode=cogs STRING COG1459 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1459&targetmode=cogs UniProtKB HOFC_ECOLI http://www.uniprot.org/uniprot/HOFC_ECOLI UniProtKB-AC P36646 http://www.uniprot.org/uniprot/P36646 charge swissprot:HOFC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HOFC_ECOLI eggNOG COG1459 http://eggnogapi.embl.de/nog_data/html/tree/COG1459 eggNOG ENOG4105D7Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D7Q epestfind swissprot:HOFC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HOFC_ECOLI garnier swissprot:HOFC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HOFC_ECOLI helixturnhelix swissprot:HOFC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HOFC_ECOLI hmoment swissprot:HOFC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HOFC_ECOLI iep swissprot:HOFC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HOFC_ECOLI inforesidue swissprot:HOFC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HOFC_ECOLI octanol swissprot:HOFC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HOFC_ECOLI pepcoil swissprot:HOFC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HOFC_ECOLI pepdigest swissprot:HOFC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HOFC_ECOLI pepinfo swissprot:HOFC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HOFC_ECOLI pepnet swissprot:HOFC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HOFC_ECOLI pepstats swissprot:HOFC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HOFC_ECOLI pepwheel swissprot:HOFC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HOFC_ECOLI pepwindow swissprot:HOFC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HOFC_ECOLI sigcleave swissprot:HOFC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HOFC_ECOLI ## Database ID URL or Descriptions # BioGrid 4259704 10 # EcoGene EG13059 yqeC # GO_function GO:0005524 ATP binding; IEA:InterPro. # GO_process GO:0009058 biosynthetic process; IEA:InterPro. # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.1190.10 -; 1. # InterPro IPR013221 Mur_ligase_cen # InterPro IPR017587 YqeC # Organism YQEC_ECOLI Escherichia coli (strain K12) # PATRIC 32121162 VBIEscCol129921_2969 # PIR D65071 D65071 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQEC_ECOLI Uncharacterized protein YqeC # RefSeq NP_417352 NC_000913.3 # RefSeq WP_001298920 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA83057.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SUPFAM SSF53623 SSF53623 # TIGRFAMs TIGR03172 TIGR03172 # eggNOG ENOG4105MJ6 Bacteria # eggNOG ENOG4111VFN LUCA BLAST swissprot:YQEC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQEC_ECOLI BioCyc ECOL316407:JW5464-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5464-MONOMER BioCyc EcoCyc:G7495-MONOMER http://biocyc.org/getid?id=EcoCyc:G7495-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 EchoBASE EB2871 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2871 EcoGene EG13059 http://www.ecogene.org/geneInfo.php?eg_id=EG13059 EnsemblBacteria AAC75914 http://www.ensemblgenomes.org/id/AAC75914 EnsemblBacteria AAC75914 http://www.ensemblgenomes.org/id/AAC75914 EnsemblBacteria BAE76942 http://www.ensemblgenomes.org/id/BAE76942 EnsemblBacteria BAE76942 http://www.ensemblgenomes.org/id/BAE76942 EnsemblBacteria BAE76942 http://www.ensemblgenomes.org/id/BAE76942 EnsemblBacteria b2876 http://www.ensemblgenomes.org/id/b2876 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.1190.10 http://www.cathdb.info/version/latest/superfamily/3.40.1190.10 GeneID 947350 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947350 HOGENOM HOG000277426 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000277426&db=HOGENOM6 InParanoid Q46809 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46809 InterPro IPR013221 http://www.ebi.ac.uk/interpro/entry/IPR013221 InterPro IPR017587 http://www.ebi.ac.uk/interpro/entry/IPR017587 KEGG_Gene ecj:JW5464 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5464 KEGG_Gene eco:b2876 http://www.genome.jp/dbget-bin/www_bget?eco:b2876 OMA HRWPLFS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HRWPLFS PSORT swissprot:YQEC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQEC_ECOLI PSORT-B swissprot:YQEC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQEC_ECOLI PSORT2 swissprot:YQEC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQEC_ECOLI Phobius swissprot:YQEC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQEC_ECOLI ProteinModelPortal Q46809 http://www.proteinmodelportal.org/query/uniprot/Q46809 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417352 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417352 RefSeq WP_001298920 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001298920 STRING 511145.b2876 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2876&targetmode=cogs SUPFAM SSF53623 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53623 TIGRFAMs TIGR03172 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03172 UniProtKB YQEC_ECOLI http://www.uniprot.org/uniprot/YQEC_ECOLI UniProtKB-AC Q46809 http://www.uniprot.org/uniprot/Q46809 charge swissprot:YQEC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQEC_ECOLI eggNOG ENOG4105MJ6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105MJ6 eggNOG ENOG4111VFN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111VFN epestfind swissprot:YQEC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQEC_ECOLI garnier swissprot:YQEC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQEC_ECOLI helixturnhelix swissprot:YQEC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQEC_ECOLI hmoment swissprot:YQEC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQEC_ECOLI iep swissprot:YQEC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQEC_ECOLI inforesidue swissprot:YQEC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQEC_ECOLI octanol swissprot:YQEC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQEC_ECOLI pepcoil swissprot:YQEC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQEC_ECOLI pepdigest swissprot:YQEC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQEC_ECOLI pepinfo swissprot:YQEC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQEC_ECOLI pepnet swissprot:YQEC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQEC_ECOLI pepstats swissprot:YQEC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQEC_ECOLI pepwheel swissprot:YQEC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQEC_ECOLI pepwindow swissprot:YQEC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQEC_ECOLI sigcleave swissprot:YQEC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQEC_ECOLI ## Database ID URL or Descriptions # AltName INSA2_ECOLI IS1b # EcoGene EG40001 insA2 # FUNCTION INSA2_ECOLI Absolutely required for transposition of IS1. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IMP:EcoCyc. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 1.10.10.60 -; 1. # InterPro IPR003220 InsA_N_dom # InterPro IPR009057 Homeodomain-like # InterPro IPR024431 InsA_HTH_dom # Organism INSA2_ECOLI Escherichia coli (strain K12) # PIR B93826 IEECB9 # PIR JN0134 JN0134 # Pfam PF03811 Zn_Tnp_IS1 # Pfam PF12759 HTH_Tnp_IS1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSA2_ECOLI Insertion element IS1 2 protein InsA # RefSeq NP_414799 NC_000913.3 # RefSeq NP_414809 NC_000913.3 # RefSeq NP_862965 NC_004998.1 # RefSeq NP_863031 NC_004998.1 # RefSeq NP_957637 NC_005327.1 # RefSeq WP_000179210 NZ_LN832404.1 # RefSeq YP_001096420 NC_009133.1 # RefSeq YP_001096518 NC_009133.1 # RefSeq YP_001816581 NC_010558.1 # RefSeq YP_001816635 NC_010558.1 # RefSeq YP_002527566 NC_011964.1 # RefSeq YP_003108318 NC_013122.1 # RefSeq YP_006953891 NC_019090.1 # RefSeq YP_006954228 NC_019095.1 # RefSeq YP_006990704 NC_019424.1 # RefSeq YP_007447506 NC_020278.2 # RefSeq YP_009071497 NC_025183.1 # RefSeq YP_588445 NC_000913.3 # SIMILARITY Belongs to the IS1 elements InsA family. {ECO 0000305}. # eggNOG COG3677 LUCA BLAST swissprot:INSA2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSA2_ECOLI BioCyc EcoCyc:G6139-MONOMER http://biocyc.org/getid?id=EcoCyc:G6139-MONOMER DOI 10.1007/BF00633835 http://dx.doi.org/10.1007/BF00633835 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L20943 http://www.ebi.ac.uk/ena/data/view/L20943 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EMBL X17345 http://www.ebi.ac.uk/ena/data/view/X17345 EchoBASE EB4706 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4706 EcoGene EG40001 http://www.ecogene.org/geneInfo.php?eg_id=EG40001 EnsemblBacteria AAC73368 http://www.ensemblgenomes.org/id/AAC73368 EnsemblBacteria AAC73368 http://www.ensemblgenomes.org/id/AAC73368 EnsemblBacteria BAE76051 http://www.ensemblgenomes.org/id/BAE76051 EnsemblBacteria BAE76051 http://www.ensemblgenomes.org/id/BAE76051 EnsemblBacteria BAE76051 http://www.ensemblgenomes.org/id/BAE76051 EnsemblBacteria b0265 http://www.ensemblgenomes.org/id/b0265 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 GeneID 13906835 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13906835 GeneID 13906917 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13906917 GeneID 13982288 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13982288 GeneID 1446608 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1446608 GeneID 1446614 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1446614 GeneID 1450250 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1450250 GeneID 14612516 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14612516 GeneID 20493569 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20493569 GeneID 2716512 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2716512 GeneID 4924745 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4924745 GeneID 4924843 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4924843 GeneID 6275933 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6275933 GeneID 6276036 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6276036 GeneID 7324590 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7324590 GeneID 8319248 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8319248 GeneID 944946 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944946 GeneID 944951 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944951 InParanoid P0CF08 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CF08 InterPro IPR003220 http://www.ebi.ac.uk/interpro/entry/IPR003220 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR024431 http://www.ebi.ac.uk/interpro/entry/IPR024431 KEGG_Gene ecj:JW0257 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0257 KEGG_Gene eco:b0265 http://www.genome.jp/dbget-bin/www_bget?eco:b0265 KEGG_Gene eco:b0275 http://www.genome.jp/dbget-bin/www_bget?eco:b0275 KEGG_Gene eco:b4516 http://www.genome.jp/dbget-bin/www_bget?eco:b4516 OMA YLCSHCH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YLCSHCH PSORT swissprot:INSA2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSA2_ECOLI PSORT-B swissprot:INSA2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSA2_ECOLI PSORT2 swissprot:INSA2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSA2_ECOLI Pfam PF03811 http://pfam.xfam.org/family/PF03811 Pfam PF12759 http://pfam.xfam.org/family/PF12759 Phobius swissprot:INSA2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSA2_ECOLI ProteinModelPortal P0CF08 http://www.proteinmodelportal.org/query/uniprot/P0CF08 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1980336 http://www.ncbi.nlm.nih.gov/pubmed/1980336 PubMed 8113168 http://www.ncbi.nlm.nih.gov/pubmed/8113168 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414799 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414799 RefSeq NP_414809 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414809 RefSeq NP_862965 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_862965 RefSeq NP_863031 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_863031 RefSeq NP_957637 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_957637 RefSeq WP_000179210 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000179210 RefSeq YP_001096420 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001096420 RefSeq YP_001096518 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001096518 RefSeq YP_001816581 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001816581 RefSeq YP_001816635 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001816635 RefSeq YP_002527566 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_002527566 RefSeq YP_003108318 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_003108318 RefSeq YP_006953891 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_006953891 RefSeq YP_006954228 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_006954228 RefSeq YP_006990704 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_006990704 RefSeq YP_007447506 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_007447506 RefSeq YP_009071497 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009071497 RefSeq YP_588445 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_588445 STRING 511145.b4516 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4516&targetmode=cogs UniProtKB INSA2_ECOLI http://www.uniprot.org/uniprot/INSA2_ECOLI UniProtKB-AC P0CF08 http://www.uniprot.org/uniprot/P0CF08 charge swissprot:INSA2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSA2_ECOLI eggNOG COG3677 http://eggnogapi.embl.de/nog_data/html/tree/COG3677 epestfind swissprot:INSA2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSA2_ECOLI garnier swissprot:INSA2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSA2_ECOLI helixturnhelix swissprot:INSA2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSA2_ECOLI hmoment swissprot:INSA2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSA2_ECOLI iep swissprot:INSA2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSA2_ECOLI inforesidue swissprot:INSA2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSA2_ECOLI octanol swissprot:INSA2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSA2_ECOLI pepcoil swissprot:INSA2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSA2_ECOLI pepdigest swissprot:INSA2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSA2_ECOLI pepinfo swissprot:INSA2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSA2_ECOLI pepnet swissprot:INSA2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSA2_ECOLI pepstats swissprot:INSA2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSA2_ECOLI pepwheel swissprot:INSA2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSA2_ECOLI pepwindow swissprot:INSA2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSA2_ECOLI sigcleave swissprot:INSA2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSA2_ECOLI ## Database ID URL or Descriptions # BioGrid 4261977 21 # EcoGene EG14256 yciU # Gene3D 3.10.450.140 -; 1. # HAMAP MF_00680 UPF0263 # INTERACTION YCIU_ECOLI P0AFG8 aceE; NbExp=2; IntAct=EBI-544511, EBI-542683; # IntAct P0A8L7 6 # InterPro IPR007376 dsDNA_mimic_put # Organism YCIU_ECOLI Escherichia coli (strain K12) # PATRIC 32117756 VBIEscCol129921_1298 # PIR C64872 C64872 # PIRSF PIRSF004916 UCP004916 # Pfam PF04269 DUF440 # ProDom PD020447 dsDNA_mimic_put # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCIU_ECOLI UPF0263 protein YciU # RefSeq NP_415764 NC_000913.3 # RefSeq WP_000366959 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0263 family. {ECO 0000305}. # SUPFAM SSF102816 SSF102816 # eggNOG COG3099 LUCA # eggNOG ENOG4108W5H Bacteria BLAST swissprot:YCIU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCIU_ECOLI BioCyc ECOL316407:JW1240-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1240-MONOMER BioCyc EcoCyc:G6633-MONOMER http://biocyc.org/getid?id=EcoCyc:G6633-MONOMER COG COG3099 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3099 DIP DIP-47882N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47882N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4004 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4004 EcoGene EG14256 http://www.ecogene.org/geneInfo.php?eg_id=EG14256 EnsemblBacteria AAC74330 http://www.ensemblgenomes.org/id/AAC74330 EnsemblBacteria AAC74330 http://www.ensemblgenomes.org/id/AAC74330 EnsemblBacteria BAA14780 http://www.ensemblgenomes.org/id/BAA14780 EnsemblBacteria BAA14780 http://www.ensemblgenomes.org/id/BAA14780 EnsemblBacteria BAA14780 http://www.ensemblgenomes.org/id/BAA14780 EnsemblBacteria b1248 http://www.ensemblgenomes.org/id/b1248 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.10.450.140 http://www.cathdb.info/version/latest/superfamily/3.10.450.140 GeneID 945819 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945819 HAMAP MF_00680 http://hamap.expasy.org/unirule/MF_00680 HOGENOM HOG000277311 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000277311&db=HOGENOM6 IntAct P0A8L7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8L7* InterPro IPR007376 http://www.ebi.ac.uk/interpro/entry/IPR007376 KEGG_Gene ecj:JW1240 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1240 KEGG_Gene eco:b1248 http://www.genome.jp/dbget-bin/www_bget?eco:b1248 KEGG_Orthology KO:K09901 http://www.genome.jp/dbget-bin/www_bget?KO:K09901 OMA QFEDRGA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QFEDRGA PSORT swissprot:YCIU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCIU_ECOLI PSORT-B swissprot:YCIU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCIU_ECOLI PSORT2 swissprot:YCIU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCIU_ECOLI Pfam PF04269 http://pfam.xfam.org/family/PF04269 Phobius swissprot:YCIU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCIU_ECOLI ProteinModelPortal P0A8L7 http://www.proteinmodelportal.org/query/uniprot/P0A8L7 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415764 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415764 RefSeq WP_000366959 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000366959 STRING 511145.b1248 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1248&targetmode=cogs STRING COG3099 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3099&targetmode=cogs SUPFAM SSF102816 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF102816 UniProtKB YCIU_ECOLI http://www.uniprot.org/uniprot/YCIU_ECOLI UniProtKB-AC P0A8L7 http://www.uniprot.org/uniprot/P0A8L7 charge swissprot:YCIU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCIU_ECOLI eggNOG COG3099 http://eggnogapi.embl.de/nog_data/html/tree/COG3099 eggNOG ENOG4108W5H http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108W5H epestfind swissprot:YCIU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCIU_ECOLI garnier swissprot:YCIU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCIU_ECOLI helixturnhelix swissprot:YCIU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCIU_ECOLI hmoment swissprot:YCIU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCIU_ECOLI iep swissprot:YCIU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCIU_ECOLI inforesidue swissprot:YCIU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCIU_ECOLI octanol swissprot:YCIU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCIU_ECOLI pepcoil swissprot:YCIU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCIU_ECOLI pepdigest swissprot:YCIU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCIU_ECOLI pepinfo swissprot:YCIU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCIU_ECOLI pepnet swissprot:YCIU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCIU_ECOLI pepstats swissprot:YCIU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCIU_ECOLI pepwheel swissprot:YCIU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCIU_ECOLI pepwindow swissprot:YCIU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCIU_ECOLI sigcleave swissprot:YCIU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCIU_ECOLI ## Database ID URL or Descriptions # BioGrid 4261282 9 # EcoGene EG14397 yibT # Gene3D 1.20.58.250 -; 1. # IntAct Q2M7R5 8 # InterPro IPR011326 HOT # Organism YIBT_ECOLI Escherichia coli (strain K12) # PATRIC 32122687 VBIEscCol129921_3720 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIBT_ECOLI Uncharacterized protein YibT # RefSeq WP_000517100 NZ_LN832404.1 # RefSeq YP_588470 NC_000913.3 # eggNOG ENOG41060ND Bacteria # eggNOG ENOG4112BWQ LUCA BLAST swissprot:YIBT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIBT_ECOLI BioCyc ECOL316407:JW3576-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3576-MONOMER BioCyc EcoCyc:MONOMER0-2690 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2690 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14397 http://www.ecogene.org/geneInfo.php?eg_id=EG14397 EnsemblBacteria ABD18704 http://www.ensemblgenomes.org/id/ABD18704 EnsemblBacteria ABD18704 http://www.ensemblgenomes.org/id/ABD18704 EnsemblBacteria BAE77691 http://www.ensemblgenomes.org/id/BAE77691 EnsemblBacteria BAE77691 http://www.ensemblgenomes.org/id/BAE77691 EnsemblBacteria BAE77691 http://www.ensemblgenomes.org/id/BAE77691 EnsemblBacteria b4554 http://www.ensemblgenomes.org/id/b4554 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 1.20.58.250 http://www.cathdb.info/version/latest/superfamily/1.20.58.250 GeneID 1450299 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1450299 HOGENOM HOG000294583 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000294583&db=HOGENOM6 IntAct Q2M7R5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q2M7R5* InterPro IPR011326 http://www.ebi.ac.uk/interpro/entry/IPR011326 KEGG_Gene ecj:JW3576 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3576 KEGG_Gene eco:b4554 http://www.genome.jp/dbget-bin/www_bget?eco:b4554 OMA VPRIIDK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VPRIIDK PSORT swissprot:YIBT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIBT_ECOLI PSORT-B swissprot:YIBT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIBT_ECOLI PSORT2 swissprot:YIBT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIBT_ECOLI Phobius swissprot:YIBT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIBT_ECOLI ProteinModelPortal Q2M7R5 http://www.proteinmodelportal.org/query/uniprot/Q2M7R5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000517100 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000517100 RefSeq YP_588470 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_588470 SMR Q2M7R5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q2M7R5 STRING 511145.b4554 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4554&targetmode=cogs UniProtKB YIBT_ECOLI http://www.uniprot.org/uniprot/YIBT_ECOLI UniProtKB-AC Q2M7R5 http://www.uniprot.org/uniprot/Q2M7R5 charge swissprot:YIBT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIBT_ECOLI eggNOG ENOG41060ND http://eggnogapi.embl.de/nog_data/html/tree/ENOG41060ND eggNOG ENOG4112BWQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4112BWQ epestfind swissprot:YIBT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIBT_ECOLI garnier swissprot:YIBT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIBT_ECOLI helixturnhelix swissprot:YIBT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIBT_ECOLI hmoment swissprot:YIBT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIBT_ECOLI iep swissprot:YIBT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIBT_ECOLI inforesidue swissprot:YIBT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIBT_ECOLI octanol swissprot:YIBT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIBT_ECOLI pepcoil swissprot:YIBT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIBT_ECOLI pepdigest swissprot:YIBT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIBT_ECOLI pepinfo swissprot:YIBT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIBT_ECOLI pepnet swissprot:YIBT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIBT_ECOLI pepstats swissprot:YIBT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIBT_ECOLI pepwheel swissprot:YIBT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIBT_ECOLI pepwindow swissprot:YIBT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIBT_ECOLI sigcleave swissprot:YIBT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIBT_ECOLI ## Database ID URL or Descriptions # BioGrid 4260433 2 # DISRUPTION PHENOTYPE Mutants show reduced intracellular nickel or cobalt levels. {ECO:0000269|PubMed 21665978}. # EcoGene EG14072 rcnB # FUNCTION RCNB_ECOLI Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly. {ECO 0000269|PubMed 21665978}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0010045 response to nickel cation; IMP:EcoCyc. # GO_process GO:0032025 response to cobalt ion; IMP:EcoCyc. # GO_process GO:1901652 response to peptide; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # INDUCTION Repressed by RcnR. Induced by nickel and cobalt. {ECO:0000269|PubMed 21665978}. # IntAct P64534 5 # InterPro IPR024572 RcnB # Organism RCNB_ECOLI Escherichia coli (strain K12) # PATRIC 32119547 VBIEscCol129921_2184 # Pfam PF11776 RcnB # ProDom PD456999 PD456999 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RCNB_ECOLI Nickel/cobalt homeostasis protein RcnB # RefSeq NP_416610 NC_000913.3 # RefSeq WP_000153067 NZ_LN832404.1 # SIMILARITY Belongs to the RcnB family. {ECO 0000305}. # SUBCELLULAR LOCATION RCNB_ECOLI Periplasm {ECO 0000269|PubMed 21665978}. # TCDB 2.A.113.1 2.a.113. the nickel/cobalt transporter (nico) family # eggNOG COG5455 LUCA # eggNOG ENOG4108Z1S Bacteria BLAST swissprot:RCNB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RCNB_ECOLI BioCyc ECOL316407:JW5346-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5346-MONOMER BioCyc EcoCyc:G7139-MONOMER http://biocyc.org/getid?id=EcoCyc:G7139-MONOMER DIP DIP-48070N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48070N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.05032-11 http://dx.doi.org/10.1128/JB.05032-11 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3825 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3825 EcoGene EG14072 http://www.ecogene.org/geneInfo.php?eg_id=EG14072 EnsemblBacteria AAC75168 http://www.ensemblgenomes.org/id/AAC75168 EnsemblBacteria AAC75168 http://www.ensemblgenomes.org/id/AAC75168 EnsemblBacteria BAE76587 http://www.ensemblgenomes.org/id/BAE76587 EnsemblBacteria BAE76587 http://www.ensemblgenomes.org/id/BAE76587 EnsemblBacteria BAE76587 http://www.ensemblgenomes.org/id/BAE76587 EnsemblBacteria b2107 http://www.ensemblgenomes.org/id/b2107 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0010045 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010045 GO_process GO:0032025 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032025 GO_process GO:1901652 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901652 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 949080 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949080 HOGENOM HOG000122121 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122121&db=HOGENOM6 IntAct P64534 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P64534* InterPro IPR024572 http://www.ebi.ac.uk/interpro/entry/IPR024572 KEGG_Gene ecj:JW5346 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5346 KEGG_Gene eco:b2107 http://www.genome.jp/dbget-bin/www_bget?eco:b2107 OMA ILKSAYS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ILKSAYS PSORT swissprot:RCNB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RCNB_ECOLI PSORT-B swissprot:RCNB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RCNB_ECOLI PSORT2 swissprot:RCNB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RCNB_ECOLI Pfam PF11776 http://pfam.xfam.org/family/PF11776 Phobius swissprot:RCNB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RCNB_ECOLI ProteinModelPortal P64534 http://www.proteinmodelportal.org/query/uniprot/P64534 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21665978 http://www.ncbi.nlm.nih.gov/pubmed/21665978 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416610 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416610 RefSeq WP_000153067 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000153067 SMR P64534 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P64534 STRING 511145.b2107 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2107&targetmode=cogs TCDB 2.A.113.1 http://www.tcdb.org/search/result.php?tc=2.A.113.1 UniProtKB RCNB_ECOLI http://www.uniprot.org/uniprot/RCNB_ECOLI UniProtKB-AC P64534 http://www.uniprot.org/uniprot/P64534 charge swissprot:RCNB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RCNB_ECOLI eggNOG COG5455 http://eggnogapi.embl.de/nog_data/html/tree/COG5455 eggNOG ENOG4108Z1S http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Z1S epestfind swissprot:RCNB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RCNB_ECOLI garnier swissprot:RCNB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RCNB_ECOLI helixturnhelix swissprot:RCNB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RCNB_ECOLI hmoment swissprot:RCNB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RCNB_ECOLI iep swissprot:RCNB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RCNB_ECOLI inforesidue swissprot:RCNB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RCNB_ECOLI octanol swissprot:RCNB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RCNB_ECOLI pepcoil swissprot:RCNB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RCNB_ECOLI pepdigest swissprot:RCNB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RCNB_ECOLI pepinfo swissprot:RCNB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RCNB_ECOLI pepnet swissprot:RCNB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RCNB_ECOLI pepstats swissprot:RCNB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RCNB_ECOLI pepwheel swissprot:RCNB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RCNB_ECOLI pepwindow swissprot:RCNB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RCNB_ECOLI sigcleave swissprot:RCNB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RCNB_ECOLI ## Database ID URL or Descriptions # AltName HYCF_ECOLI Hydrogenase-3 component F # BioGrid 4262940 11 # EcoGene EG10479 hycF # FUNCTION HYCF_ECOLI Probable electron transfer protein for hydrogenase 3. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0055114 oxidation-reduction process; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # IntAct P16432 10 # InterPro IPR017896 4Fe4S_Fe-S-bd # InterPro IPR017900 4Fe4S_Fe_S_CS # Organism HYCF_ECOLI Escherichia coli (strain K12) # PATRIC 32120840 VBIEscCol129921_2812 # PIR S08624 S08624 # PROSITE PS00198 4FE4S_FER_1; 2 # PROSITE PS51379 4FE4S_FER_2; 2 # Pfam PF12838 Fer4_7 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HYCF_ECOLI Formate hydrogenlyase subunit 6 # RefSeq NP_417200 NC_000913.3 # RefSeq WP_000493781 NZ_LN832404.1 # SIMILARITY Contains 2 4Fe-4S ferredoxin-type domains. {ECO:0000255|PROSITE-ProRule PRU00711}. # SUBUNIT HYCF_ECOLI FHL comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (isoenzyme 3). In this non- energy conserving pathway, molecular hydrogen and carbodioxide are released from formate. # TCDB 3.D.1.9 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family # eggNOG COG1143 LUCA # eggNOG ENOG4108RG7 Bacteria BLAST swissprot:HYCF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HYCF_ECOLI BioCyc ECOL316407:JW2690-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2690-MONOMER BioCyc EcoCyc:HYCF-MONOMER http://biocyc.org/getid?id=EcoCyc:HYCF-MONOMER BioCyc MetaCyc:HYCF-MONOMER http://biocyc.org/getid?id=MetaCyc:HYCF-MONOMER COG COG1143 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1143 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1990.tb00590.x http://dx.doi.org/10.1111/j.1365-2958.1990.tb00590.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EMBL X17506 http://www.ebi.ac.uk/ena/data/view/X17506 EchoBASE EB0474 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0474 EcoGene EG10479 http://www.ecogene.org/geneInfo.php?eg_id=EG10479 EnsemblBacteria AAC75762 http://www.ensemblgenomes.org/id/AAC75762 EnsemblBacteria AAC75762 http://www.ensemblgenomes.org/id/AAC75762 EnsemblBacteria BAE76797 http://www.ensemblgenomes.org/id/BAE76797 EnsemblBacteria BAE76797 http://www.ensemblgenomes.org/id/BAE76797 EnsemblBacteria BAE76797 http://www.ensemblgenomes.org/id/BAE76797 EnsemblBacteria b2720 http://www.ensemblgenomes.org/id/b2720 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0055114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 947048 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947048 HOGENOM HOG000278697 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278697&db=HOGENOM6 InParanoid P16432 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P16432 IntAct P16432 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P16432* InterPro IPR017896 http://www.ebi.ac.uk/interpro/entry/IPR017896 InterPro IPR017900 http://www.ebi.ac.uk/interpro/entry/IPR017900 KEGG_Gene ecj:JW2690 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2690 KEGG_Gene eco:b2720 http://www.genome.jp/dbget-bin/www_bget?eco:b2720 KEGG_Orthology KO:K15831 http://www.genome.jp/dbget-bin/www_bget?KO:K15831 OMA HHRESFE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HHRESFE PROSITE PS00198 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00198 PROSITE PS51379 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51379 PSORT swissprot:HYCF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HYCF_ECOLI PSORT-B swissprot:HYCF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HYCF_ECOLI PSORT2 swissprot:HYCF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HYCF_ECOLI Pfam PF12838 http://pfam.xfam.org/family/PF12838 Phobius swissprot:HYCF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HYCF_ECOLI PhylomeDB P16432 http://phylomedb.org/?seqid=P16432 ProteinModelPortal P16432 http://www.proteinmodelportal.org/query/uniprot/P16432 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2187144 http://www.ncbi.nlm.nih.gov/pubmed/2187144 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417200 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417200 RefSeq WP_000493781 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000493781 SMR P16432 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P16432 STRING 511145.b2720 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2720&targetmode=cogs STRING COG1143 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1143&targetmode=cogs TCDB 3.D.1.9 http://www.tcdb.org/search/result.php?tc=3.D.1.9 UniProtKB HYCF_ECOLI http://www.uniprot.org/uniprot/HYCF_ECOLI UniProtKB-AC P16432 http://www.uniprot.org/uniprot/P16432 charge swissprot:HYCF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HYCF_ECOLI eggNOG COG1143 http://eggnogapi.embl.de/nog_data/html/tree/COG1143 eggNOG ENOG4108RG7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108RG7 epestfind swissprot:HYCF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HYCF_ECOLI garnier swissprot:HYCF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HYCF_ECOLI helixturnhelix swissprot:HYCF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HYCF_ECOLI hmoment swissprot:HYCF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HYCF_ECOLI iep swissprot:HYCF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HYCF_ECOLI inforesidue swissprot:HYCF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HYCF_ECOLI octanol swissprot:HYCF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HYCF_ECOLI pepcoil swissprot:HYCF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HYCF_ECOLI pepdigest swissprot:HYCF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HYCF_ECOLI pepinfo swissprot:HYCF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HYCF_ECOLI pepnet swissprot:HYCF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HYCF_ECOLI pepstats swissprot:HYCF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HYCF_ECOLI pepwheel swissprot:HYCF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HYCF_ECOLI pepwindow swissprot:HYCF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HYCF_ECOLI sigcleave swissprot:HYCF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HYCF_ECOLI ## Database ID URL or Descriptions # BioGrid 4261996 20 # DISRUPTION PHENOTYPE Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain. {ECO:0000269|PubMed 20345943}. # EcoGene EG12774 yraI # FUNCTION YRAI_ECOLI Part of the yraHIJK fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim operon. {ECO 0000269|PubMed 20345943}. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IEA:InterPro. # GO_function GO:0044183 protein binding involved in protein folding; IBA:GO_Central. # GO_process GO:0043711 pilus organization; IBA:GO_Central. # GO_process GO:0061077 chaperone-mediated protein folding; IBA:GO_Central. # GO_process GO:0071555 cell wall organization; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006457 protein folding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 2.60.40.1070 -; 1. # Gene3D 2.60.40.360 -; 1. # INDUCTION Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression. {ECO:0000269|PubMed 20345943}. # IntAct P42914 5 # InterPro IPR001829 Pili_assmbl_chaperone_bac # InterPro IPR008962 PapD-like # InterPro IPR016147 Pili_assmbl_chaperone_N # InterPro IPR016148 Pili_assmbl_chaperone_C # InterPro IPR018046 Pili_assmbl_chaperone_CS # MISCELLANEOUS The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed. {ECO:0000305|PubMed 20345943}. # Organism YRAI_ECOLI Escherichia coli (strain K12) # PATRIC 32121704 VBIEscCol129921_3238 # PIR C65104 C65104 # PRINTS PR00969 CHAPERONPILI # PROSITE PS00635 PILI_CHAPERONE # Pfam PF00345 PapD_N # Pfam PF02753 PapD_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YRAI_ECOLI Probable fimbrial chaperone YraI # RefSeq NP_417612 NC_000913.3 # RefSeq WP_000044775 NZ_LN832404.1 # SIMILARITY Belongs to the periplasmic pilus chaperone family. {ECO 0000305}. # SIMILARITY Contains 1 Ig-like (immunoglobulin-like) domain. {ECO 0000305}. # SUBCELLULAR LOCATION YRAI_ECOLI Periplasm {ECO 0000250}. # SUPFAM SSF49354 SSF49354 # SUPFAM SSF49584 SSF49584 # eggNOG ENOG4108VCD Bacteria # eggNOG ENOG4111N65 LUCA BLAST swissprot:YRAI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YRAI_ECOLI BioCyc ECOL316407:JW3112-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3112-MONOMER BioCyc EcoCyc:G7638-MONOMER http://biocyc.org/getid?id=EcoCyc:G7638-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1462-2920.2010.02202.x http://dx.doi.org/10.1111/j.1462-2920.2010.02202.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2627 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2627 EcoGene EG12774 http://www.ecogene.org/geneInfo.php?eg_id=EG12774 EnsemblBacteria AAC76177 http://www.ensemblgenomes.org/id/AAC76177 EnsemblBacteria AAC76177 http://www.ensemblgenomes.org/id/AAC76177 EnsemblBacteria BAE77189 http://www.ensemblgenomes.org/id/BAE77189 EnsemblBacteria BAE77189 http://www.ensemblgenomes.org/id/BAE77189 EnsemblBacteria BAE77189 http://www.ensemblgenomes.org/id/BAE77189 EnsemblBacteria b3143 http://www.ensemblgenomes.org/id/b3143 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0044183 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044183 GO_process GO:0043711 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043711 GO_process GO:0061077 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061077 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 2.60.40.1070 http://www.cathdb.info/version/latest/superfamily/2.60.40.1070 Gene3D 2.60.40.360 http://www.cathdb.info/version/latest/superfamily/2.60.40.360 GeneID 947657 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947657 HOGENOM HOG000260152 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260152&db=HOGENOM6 InParanoid P42914 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P42914 IntAct P42914 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P42914* InterPro IPR001829 http://www.ebi.ac.uk/interpro/entry/IPR001829 InterPro IPR008962 http://www.ebi.ac.uk/interpro/entry/IPR008962 InterPro IPR016147 http://www.ebi.ac.uk/interpro/entry/IPR016147 InterPro IPR016148 http://www.ebi.ac.uk/interpro/entry/IPR016148 InterPro IPR018046 http://www.ebi.ac.uk/interpro/entry/IPR018046 KEGG_Gene ecj:JW3112 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3112 KEGG_Gene eco:b3143 http://www.genome.jp/dbget-bin/www_bget?eco:b3143 OMA VIYEASK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VIYEASK PRINTS PR00969 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00969 PROSITE PS00635 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00635 PSORT swissprot:YRAI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YRAI_ECOLI PSORT-B swissprot:YRAI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YRAI_ECOLI PSORT2 swissprot:YRAI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YRAI_ECOLI Pfam PF00345 http://pfam.xfam.org/family/PF00345 Pfam PF02753 http://pfam.xfam.org/family/PF02753 Phobius swissprot:YRAI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YRAI_ECOLI PhylomeDB P42914 http://phylomedb.org/?seqid=P42914 ProteinModelPortal P42914 http://www.proteinmodelportal.org/query/uniprot/P42914 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20345943 http://www.ncbi.nlm.nih.gov/pubmed/20345943 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417612 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417612 RefSeq WP_000044775 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000044775 SMR P42914 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P42914 STRING 511145.b3143 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3143&targetmode=cogs SUPFAM SSF49354 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49354 SUPFAM SSF49584 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49584 UniProtKB YRAI_ECOLI http://www.uniprot.org/uniprot/YRAI_ECOLI UniProtKB-AC P42914 http://www.uniprot.org/uniprot/P42914 charge swissprot:YRAI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YRAI_ECOLI eggNOG ENOG4108VCD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108VCD eggNOG ENOG4111N65 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111N65 epestfind swissprot:YRAI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YRAI_ECOLI garnier swissprot:YRAI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YRAI_ECOLI helixturnhelix swissprot:YRAI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YRAI_ECOLI hmoment swissprot:YRAI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YRAI_ECOLI iep swissprot:YRAI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YRAI_ECOLI inforesidue swissprot:YRAI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YRAI_ECOLI octanol swissprot:YRAI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YRAI_ECOLI pepcoil swissprot:YRAI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YRAI_ECOLI pepdigest swissprot:YRAI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YRAI_ECOLI pepinfo swissprot:YRAI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YRAI_ECOLI pepnet swissprot:YRAI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YRAI_ECOLI pepstats swissprot:YRAI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YRAI_ECOLI pepwheel swissprot:YRAI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YRAI_ECOLI pepwindow swissprot:YRAI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YRAI_ECOLI sigcleave swissprot:YRAI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YRAI_ECOLI ## Database ID URL or Descriptions # AltName NADH dehydrogenase I subunit N {ECO:0000255|HAMAP-Rule MF_00445} # AltName NDH-1 subunit N {ECO:0000255|HAMAP-Rule MF_00445} # AltName NUON_ECOLI NUO14 # BioGrid 4260885 25 # CATALYTIC ACTIVITY NADH + a quinone = NAD(+) + a quinol. {ECO:0000255|HAMAP-Rule MF_00445}. # DISRUPTION PHENOTYPE Cells gene grow very poorly on M65 minimal medium containing acetate but normally on rich medium (LB). {ECO:0000269|PubMed 12718520}. # EcoGene EG12093 nuoN # FUNCTION NUON_ECOLI NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0030964 NADH dehydrogenase complex; IDA:EcoliWiki. # GO_component GO:0045272 plasma membrane respiratory chain complex I; IDA:EcoCyc. # GO_function GO:0008137 NADH dehydrogenase (ubiquinone) activity; IMP:EcoCyc. # GO_function GO:0048038 quinone binding; IEA:UniProtKB-KW. # GO_process GO:0009060 aerobic respiration; IMP:EcoCyc. # GO_process GO:0015990 electron transport coupled proton transport; IMP:EcoCyc. # GO_process GO:0042773 ATP synthesis coupled electron transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0055085 transmembrane transport # HAMAP MF_00445 NDH1_NuoN_1 # InterPro IPR001750 ND/Mrp_mem # InterPro IPR010096 NADH-Q_OxRdtase_suN/2 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00190 Oxidative phosphorylation # KEGG_Pathway ko00910 Nitrogen metabolism # MISCELLANEOUS NUON_ECOLI A construct which produces a protein lacking the first amino acids has only 5% of the wild-type rate of deamino- NADH oxidase. # Organism NUON_ECOLI Escherichia coli (strain K12) # PATRIC 32119919 VBIEscCol129921_2369 # PIR B64999 B64999 # PIR S38323 S38323 # Pfam PF00361 Proton_antipo_M # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NADH-quinone oxidoreductase subunit N {ECO:0000255|HAMAP-Rule MF_00445} # RefSeq NP_416779 NC_000913.3 # RefSeq WP_000156701 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA16103.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA48373.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the complex I subunit 2 family. {ECO:0000255|HAMAP-Rule MF_00445}. # SUBCELLULAR LOCATION NUON_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT NUON_ECOLI NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex. # TCDB 3.D.1.1 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family # TIGRFAMs TIGR01770 NDH_I_N # eggNOG COG1007 LUCA # eggNOG ENOG4105CNR Bacteria BLAST swissprot:NUON_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NUON_ECOLI BioCyc ECOL316407:JW2271-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2271-MONOMER BioCyc EcoCyc:NUON-MONOMER http://biocyc.org/getid?id=EcoCyc:NUON-MONOMER BioCyc MetaCyc:NUON-MONOMER http://biocyc.org/getid?id=MetaCyc:NUON-MONOMER COG COG1007 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1007 DIP DIP-59256N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-59256N DOI 10.1006/jmbi.1993.1488 http://dx.doi.org/10.1006/jmbi.1993.1488 DOI 10.1021/bi0340346 http://dx.doi.org/10.1021/bi0340346 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.6.5.11 {ECO:0000255|HAMAP-Rule:MF_00445} http://www.genome.jp/dbget-bin/www_bget?EC:1.6.5.11 {ECO:0000255|HAMAP-Rule:MF_00445} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X68301 http://www.ebi.ac.uk/ena/data/view/X68301 ENZYME 1.6.5.11 {ECO:0000255|HAMAP-Rule:MF_00445} http://enzyme.expasy.org/EC/1.6.5.11 {ECO:0000255|HAMAP-Rule:MF_00445} EchoBASE EB2017 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2017 EcoGene EG12093 http://www.ecogene.org/geneInfo.php?eg_id=EG12093 EnsemblBacteria AAC75336 http://www.ensemblgenomes.org/id/AAC75336 EnsemblBacteria AAC75336 http://www.ensemblgenomes.org/id/AAC75336 EnsemblBacteria BAA16103 http://www.ensemblgenomes.org/id/BAA16103 EnsemblBacteria BAA16103 http://www.ensemblgenomes.org/id/BAA16103 EnsemblBacteria BAA16103 http://www.ensemblgenomes.org/id/BAA16103 EnsemblBacteria b2276 http://www.ensemblgenomes.org/id/b2276 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0030964 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030964 GO_component GO:0045272 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045272 GO_function GO:0008137 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008137 GO_function GO:0048038 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048038 GO_process GO:0009060 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009060 GO_process GO:0015990 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015990 GO_process GO:0042773 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042773 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 945136 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945136 HAMAP MF_00445 http://hamap.expasy.org/unirule/MF_00445 HOGENOM HOG000100796 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000100796&db=HOGENOM6 InParanoid P0AFF0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFF0 IntEnz 1.6.5.11 {ECO:0000255|HAMAP-Rule:MF_00445} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.6.5.11 {ECO:0000255|HAMAP-Rule:MF_00445} InterPro IPR001750 http://www.ebi.ac.uk/interpro/entry/IPR001750 InterPro IPR010096 http://www.ebi.ac.uk/interpro/entry/IPR010096 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2271 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2271 KEGG_Gene eco:b2276 http://www.genome.jp/dbget-bin/www_bget?eco:b2276 KEGG_Orthology KO:K00343 http://www.genome.jp/dbget-bin/www_bget?KO:K00343 KEGG_Pathway ko00190 http://www.genome.jp/kegg-bin/show_pathway?ko00190 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Reaction rn:R02166 http://www.genome.jp/dbget-bin/www_bget?rn:R02166 OMA YALILMT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YALILMT PSORT swissprot:NUON_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NUON_ECOLI PSORT-B swissprot:NUON_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NUON_ECOLI PSORT2 swissprot:NUON_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NUON_ECOLI Pfam PF00361 http://pfam.xfam.org/family/PF00361 Phobius swissprot:NUON_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NUON_ECOLI PhylomeDB P0AFF0 http://phylomedb.org/?seqid=P0AFF0 ProteinModelPortal P0AFF0 http://www.proteinmodelportal.org/query/uniprot/P0AFF0 PubMed 12718520 http://www.ncbi.nlm.nih.gov/pubmed/12718520 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7690854 http://www.ncbi.nlm.nih.gov/pubmed/7690854 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416779 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416779 RefSeq WP_000156701 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000156701 STRING 511145.b2276 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2276&targetmode=cogs STRING COG1007 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1007&targetmode=cogs TCDB 3.D.1.1 http://www.tcdb.org/search/result.php?tc=3.D.1.1 TIGRFAMs TIGR01770 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01770 UniProtKB NUON_ECOLI http://www.uniprot.org/uniprot/NUON_ECOLI UniProtKB-AC P0AFF0 http://www.uniprot.org/uniprot/P0AFF0 charge swissprot:NUON_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NUON_ECOLI eggNOG COG1007 http://eggnogapi.embl.de/nog_data/html/tree/COG1007 eggNOG ENOG4105CNR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CNR epestfind swissprot:NUON_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NUON_ECOLI garnier swissprot:NUON_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NUON_ECOLI helixturnhelix swissprot:NUON_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NUON_ECOLI hmoment swissprot:NUON_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NUON_ECOLI iep swissprot:NUON_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NUON_ECOLI inforesidue swissprot:NUON_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NUON_ECOLI octanol swissprot:NUON_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NUON_ECOLI pepcoil swissprot:NUON_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NUON_ECOLI pepdigest swissprot:NUON_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NUON_ECOLI pepinfo swissprot:NUON_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NUON_ECOLI pepnet swissprot:NUON_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NUON_ECOLI pepstats swissprot:NUON_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NUON_ECOLI pepwheel swissprot:NUON_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NUON_ECOLI pepwindow swissprot:NUON_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NUON_ECOLI sigcleave swissprot:NUON_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NUON_ECOLI ## Database ID URL or Descriptions # AltName GUAD_ECOLI Guanine aminohydrolase # BioGrid 4259227 7 # CATALYTIC ACTIVITY GUAD_ECOLI Guanine + H(2)O = xanthine + NH(3). # CDD cd01303 GDEase # COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI 29105; Note=Binds 1 zinc ion per subunit.; # EcoGene EG13066 guaD # FUNCTION GUAD_ECOLI Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_function GO:0008892 guanine deaminase activity; IDA:EcoCyc. # GO_function GO:0018756 ammeline aminohydrolase activity; IMP:EcoCyc. # GO_process GO:0006147 guanine catabolic process; IEA:UniProtKB-UniPathway. # GO_process GO:0046098 guanine metabolic process; IBA:GO_Central. # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 2.30.40.10 -; 2. # InterPro IPR006680 Amidohydro-rel # InterPro IPR011059 Metal-dep_hydrolase_composite # InterPro IPR014311 Guanine_deaminase # InterPro IPR032466 Metal_Hydrolase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # Organism GUAD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11271:SF6 PTHR11271:SF6 # PATHWAY Purine metabolism; guanine degradation; xanthine from guanine step 1/1. # PATRIC 32121176 VBIEscCol129921_2976 # PIR C65072 C65072 # Pfam PF01979 Amidohydro_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GUAD_ECOLI Guanine deaminase # RefSeq NP_417359 NC_000913.3 # SIMILARITY Belongs to the ATZ/TRZ family. {ECO 0000305}. # SUPFAM SSF51338 SSF51338 # SUPFAM SSF51556 SSF51556 # TIGRFAMs TIGR02967 guan_deamin # UniPathway UPA00603 UER00660 # eggNOG COG0402 LUCA # eggNOG ENOG4107QUY Bacteria BLAST swissprot:GUAD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GUAD_ECOLI BioCyc ECOL316407:JW5466-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5466-MONOMER BioCyc EcoCyc:G7502-MONOMER http://biocyc.org/getid?id=EcoCyc:G7502-MONOMER BioCyc MetaCyc:G7502-MONOMER http://biocyc.org/getid?id=MetaCyc:G7502-MONOMER COG COG0402 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0402 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.16.4658-4660.2000 http://dx.doi.org/10.1128/JB.182.16.4658-4660.2000 EC_number EC:3.5.4.3 http://www.genome.jp/dbget-bin/www_bget?EC:3.5.4.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 ENZYME 3.5.4.3 http://enzyme.expasy.org/EC/3.5.4.3 EchoBASE EB2878 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2878 EcoGene EG13066 http://www.ecogene.org/geneInfo.php?eg_id=EG13066 EnsemblBacteria AAC75921 http://www.ensemblgenomes.org/id/AAC75921 EnsemblBacteria AAC75921 http://www.ensemblgenomes.org/id/AAC75921 EnsemblBacteria BAE76949 http://www.ensemblgenomes.org/id/BAE76949 EnsemblBacteria BAE76949 http://www.ensemblgenomes.org/id/BAE76949 EnsemblBacteria BAE76949 http://www.ensemblgenomes.org/id/BAE76949 EnsemblBacteria b2883 http://www.ensemblgenomes.org/id/b2883 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0008892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008892 GO_function GO:0018756 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018756 GO_process GO:0006147 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006147 GO_process GO:0046098 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046098 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 2.30.40.10 http://www.cathdb.info/version/latest/superfamily/2.30.40.10 GeneID 947366 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947366 HOGENOM HOG000257693 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000257693&db=HOGENOM6 InParanoid P76641 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76641 IntEnz 3.5.4.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.4.3 InterPro IPR006680 http://www.ebi.ac.uk/interpro/entry/IPR006680 InterPro IPR011059 http://www.ebi.ac.uk/interpro/entry/IPR011059 InterPro IPR014311 http://www.ebi.ac.uk/interpro/entry/IPR014311 InterPro IPR032466 http://www.ebi.ac.uk/interpro/entry/IPR032466 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5466 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5466 KEGG_Gene eco:b2883 http://www.genome.jp/dbget-bin/www_bget?eco:b2883 KEGG_Orthology KO:K01487 http://www.genome.jp/dbget-bin/www_bget?KO:K01487 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Reaction rn:R01676 http://www.genome.jp/dbget-bin/www_bget?rn:R01676 OMA DFFGDIS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DFFGDIS PANTHER PTHR11271:SF6 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11271:SF6 PSORT swissprot:GUAD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GUAD_ECOLI PSORT-B swissprot:GUAD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GUAD_ECOLI PSORT2 swissprot:GUAD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GUAD_ECOLI Pfam PF01979 http://pfam.xfam.org/family/PF01979 Phobius swissprot:GUAD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GUAD_ECOLI PhylomeDB P76641 http://phylomedb.org/?seqid=P76641 ProteinModelPortal P76641 http://www.proteinmodelportal.org/query/uniprot/P76641 PubMed 10913105 http://www.ncbi.nlm.nih.gov/pubmed/10913105 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417359 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417359 SMR P76641 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76641 STRING 511145.b2883 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2883&targetmode=cogs STRING COG0402 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0402&targetmode=cogs SUPFAM SSF51338 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51338 SUPFAM SSF51556 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51556 TIGRFAMs TIGR02967 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02967 UniProtKB GUAD_ECOLI http://www.uniprot.org/uniprot/GUAD_ECOLI UniProtKB-AC P76641 http://www.uniprot.org/uniprot/P76641 charge swissprot:GUAD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GUAD_ECOLI eggNOG COG0402 http://eggnogapi.embl.de/nog_data/html/tree/COG0402 eggNOG ENOG4107QUY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QUY epestfind swissprot:GUAD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GUAD_ECOLI garnier swissprot:GUAD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GUAD_ECOLI helixturnhelix swissprot:GUAD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GUAD_ECOLI hmoment swissprot:GUAD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GUAD_ECOLI iep swissprot:GUAD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GUAD_ECOLI inforesidue swissprot:GUAD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GUAD_ECOLI octanol swissprot:GUAD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GUAD_ECOLI pepcoil swissprot:GUAD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GUAD_ECOLI pepdigest swissprot:GUAD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GUAD_ECOLI pepinfo swissprot:GUAD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GUAD_ECOLI pepnet swissprot:GUAD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GUAD_ECOLI pepstats swissprot:GUAD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GUAD_ECOLI pepwheel swissprot:GUAD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GUAD_ECOLI pepwindow swissprot:GUAD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GUAD_ECOLI sigcleave swissprot:GUAD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GUAD_ECOLI ## Database ID URL or Descriptions # BioGrid 4262888 52 # BioGrid 4262889 186 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG14258 yncI # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # InterPro IPR002559 Transposase_11 # InterPro IPR032806 YbfD_N # Organism YNCI_ECOLI Escherichia coli (strain K12) # PATRIC 48662227 VBIEscCol107702_1475 # PIR E64898 E64898 # PIR F64898 F64898 # Pfam PF01609 DDE_Tnp_1 # Pfam PF13808 DDE_Tnp_1_assoc # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNCI_ECOLI Putative transposase YncI # SEQUENCE CAUTION Sequence=BAA15089.2; Type=Frameshift; Positions=245; Evidence={ECO:0000305}; Sequence=BAA15090.2; Type=Erroneous termination; Positions=331; Note=Translated as Glu.; Evidence={ECO 0000305}; Sequence=U00096; Type=Erroneous termination; Positions=331; Note=Translated as Glu.; Evidence={ECO:0000305}; # SIMILARITY Belongs to the transposase 11 family. {ECO 0000305}. # eggNOG COG5433 LUCA BLAST swissprot:YNCI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNCI_ECOLI BioCyc ECOL316407:JW1453-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1453-MONOMER BioCyc ECOL316407:JW5237-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5237-MONOMER BioCyc EcoCyc:G6767-MONOMER http://biocyc.org/getid?id=EcoCyc:G6767-MONOMER BioCyc EcoCyc:G6768-MONOMER http://biocyc.org/getid?id=EcoCyc:G6768-MONOMER DIP DIP-28080N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-28080N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14258 http://www.ecogene.org/geneInfo.php?eg_id=EG14258 EnsemblBacteria BAA15089 http://www.ensemblgenomes.org/id/BAA15089 EnsemblBacteria BAA15089 http://www.ensemblgenomes.org/id/BAA15089 EnsemblBacteria BAA15089 http://www.ensemblgenomes.org/id/BAA15089 EnsemblBacteria BAA15090 http://www.ensemblgenomes.org/id/BAA15090 EnsemblBacteria BAA15090 http://www.ensemblgenomes.org/id/BAA15090 EnsemblBacteria BAA15090 http://www.ensemblgenomes.org/id/BAA15090 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 HOGENOM HOG000042098 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000042098&db=HOGENOM6 InParanoid P76119 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76119 IntAct P76119 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76119* InterPro IPR002559 http://www.ebi.ac.uk/interpro/entry/IPR002559 InterPro IPR032806 http://www.ebi.ac.uk/interpro/entry/IPR032806 KEGG_Gene ecj:JW1453 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1453 KEGG_Gene ecj:JW5237 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5237 OMA DYGHGRI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DYGHGRI PSORT swissprot:YNCI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNCI_ECOLI PSORT-B swissprot:YNCI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNCI_ECOLI PSORT2 swissprot:YNCI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNCI_ECOLI Pfam PF01609 http://pfam.xfam.org/family/PF01609 Pfam PF13808 http://pfam.xfam.org/family/PF13808 Phobius swissprot:YNCI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNCI_ECOLI PhylomeDB P76119 http://phylomedb.org/?seqid=P76119 ProteinModelPortal P76119 http://www.proteinmodelportal.org/query/uniprot/P76119 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SMR P76119 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76119 STRING 316407.85674976 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85674976&targetmode=cogs UniProtKB YNCI_ECOLI http://www.uniprot.org/uniprot/YNCI_ECOLI UniProtKB-AC P76119 http://www.uniprot.org/uniprot/P76119 charge swissprot:YNCI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNCI_ECOLI eggNOG COG5433 http://eggnogapi.embl.de/nog_data/html/tree/COG5433 epestfind swissprot:YNCI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNCI_ECOLI garnier swissprot:YNCI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNCI_ECOLI helixturnhelix swissprot:YNCI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNCI_ECOLI hmoment swissprot:YNCI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNCI_ECOLI iep swissprot:YNCI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNCI_ECOLI inforesidue swissprot:YNCI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNCI_ECOLI octanol swissprot:YNCI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNCI_ECOLI pepcoil swissprot:YNCI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNCI_ECOLI pepdigest swissprot:YNCI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNCI_ECOLI pepinfo swissprot:YNCI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNCI_ECOLI pepnet swissprot:YNCI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNCI_ECOLI pepstats swissprot:YNCI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNCI_ECOLI pepwheel swissprot:YNCI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNCI_ECOLI pepwindow swissprot:YNCI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNCI_ECOLI sigcleave swissprot:YNCI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNCI_ECOLI ## Database ID URL or Descriptions # EcoGene EG40009 insI3 # FUNCTION INSI3_ECOLI Required for the transposition of the insertion element. {ECO 0000305}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004803 transposase activity; IDA:EcoCyc. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GO_process GO:0015074 DNA integration; IEA:InterPro. # GO_process GO:0032196 transposition; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 3.30.420.10 -; 1. # InterPro IPR001584 Integrase_cat-core # InterPro IPR001598 Transposase_IS30_CS # InterPro IPR012337 RNaseH-like_dom # InterPro IPR025246 IS30-like_HTH # Organism INSI3_ECOLI Escherichia coli (strain K12) # PIR F65241 F65241 # PROSITE PS01043 TRANSPOSASE_IS30 # PROSITE PS50994 INTEGRASE # Pfam PF00665 rve # Pfam PF13936 HTH_38 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSI3_ECOLI Transposase InsI for insertion sequence element IS30C # RefSeq NP_415922 NC_000913.3 # RefSeq NP_418704 NC_000913.3 # RefSeq WP_001254932 NZ_LN832404.1 # RefSeq YP_001294740 NC_009602.1 # SIMILARITY Belongs to the transposase IS30 family. {ECO 0000305}. # SIMILARITY Contains 1 integrase catalytic domain. {ECO:0000255|PROSITE-ProRule PRU00457}. # SUPFAM SSF53098 SSF53098 # eggNOG COG2826 LUCA # eggNOG ENOG4105F9F Bacteria BLAST swissprot:INSI3_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSI3_ECOLI BioCyc EcoCyc:G6725-MONOMER http://biocyc.org/getid?id=EcoCyc:G6725-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X00792 http://www.ebi.ac.uk/ena/data/view/X00792 EchoBASE EB4755 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4755 EcoGene EG40009 http://www.ecogene.org/geneInfo.php?eg_id=EG40009 EnsemblBacteria AAC74486 http://www.ensemblgenomes.org/id/AAC74486 EnsemblBacteria AAC74486 http://www.ensemblgenomes.org/id/AAC74486 EnsemblBacteria BAA15014 http://www.ensemblgenomes.org/id/BAA15014 EnsemblBacteria BAA15014 http://www.ensemblgenomes.org/id/BAA15014 EnsemblBacteria BAA15014 http://www.ensemblgenomes.org/id/BAA15014 EnsemblBacteria b1404 http://www.ensemblgenomes.org/id/b1404 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GO_process GO:0015074 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015074 GO_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 3.30.420.10 http://www.cathdb.info/version/latest/superfamily/3.30.420.10 GeneID 5290948 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5290948 GeneID 945968 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945968 GeneID 948815 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948815 HOGENOM HOG000114767 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000114767&db=HOGENOM6 InParanoid P0CF89 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CF89 InterPro IPR001584 http://www.ebi.ac.uk/interpro/entry/IPR001584 InterPro IPR001598 http://www.ebi.ac.uk/interpro/entry/IPR001598 InterPro IPR012337 http://www.ebi.ac.uk/interpro/entry/IPR012337 InterPro IPR025246 http://www.ebi.ac.uk/interpro/entry/IPR025246 KEGG_Gene ecj:JW1401 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1401 KEGG_Gene eco:b1404 http://www.genome.jp/dbget-bin/www_bget?eco:b1404 KEGG_Gene eco:b4284 http://www.genome.jp/dbget-bin/www_bget?eco:b4284 PROSITE PS01043 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01043 PROSITE PS50994 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50994 PSORT swissprot:INSI3_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSI3_ECOLI PSORT-B swissprot:INSI3_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSI3_ECOLI PSORT2 swissprot:INSI3_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSI3_ECOLI Pfam PF00665 http://pfam.xfam.org/family/PF00665 Pfam PF13936 http://pfam.xfam.org/family/PF13936 Phobius swissprot:INSI3_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSI3_ECOLI PhylomeDB P0CF89 http://phylomedb.org/?seqid=P0CF89 ProteinModelPortal P0CF89 http://www.proteinmodelportal.org/query/uniprot/P0CF89 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6092059 http://www.ncbi.nlm.nih.gov/pubmed/6092059 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415922 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415922 RefSeq NP_418704 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418704 RefSeq WP_001254932 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001254932 RefSeq YP_001294740 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001294740 STRING 511145.b4284 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4284&targetmode=cogs SUPFAM SSF53098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098 UniProtKB INSI3_ECOLI http://www.uniprot.org/uniprot/INSI3_ECOLI UniProtKB-AC P0CF89 http://www.uniprot.org/uniprot/P0CF89 charge swissprot:INSI3_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSI3_ECOLI eggNOG COG2826 http://eggnogapi.embl.de/nog_data/html/tree/COG2826 eggNOG ENOG4105F9F http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F9F epestfind swissprot:INSI3_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSI3_ECOLI garnier swissprot:INSI3_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSI3_ECOLI helixturnhelix swissprot:INSI3_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSI3_ECOLI hmoment swissprot:INSI3_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSI3_ECOLI iep swissprot:INSI3_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSI3_ECOLI inforesidue swissprot:INSI3_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSI3_ECOLI octanol swissprot:INSI3_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSI3_ECOLI pepcoil swissprot:INSI3_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSI3_ECOLI pepdigest swissprot:INSI3_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSI3_ECOLI pepinfo swissprot:INSI3_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSI3_ECOLI pepnet swissprot:INSI3_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSI3_ECOLI pepstats swissprot:INSI3_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSI3_ECOLI pepwheel swissprot:INSI3_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSI3_ECOLI pepwindow swissprot:INSI3_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSI3_ECOLI sigcleave swissprot:INSI3_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSI3_ECOLI ## Database ID URL or Descriptions # BioGrid 4261572 15 # EcoGene EG12154 sieB # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR025982 SieB # Organism SIEB_ECOLI Escherichia coli (strain K12) # PATRIC 32117986 VBIEscCol129921_1413 # Pfam PF14163 SieB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SIEB_ECOLI Superinfection exclusion protein B # RefSeq NP_415870 NC_000913.3 # RefSeq WP_001312793 NZ_CP014272.1 # SUBCELLULAR LOCATION SIEB_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. BLAST swissprot:SIEB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SIEB_ECOLI BioCyc ECOL316407:JW5209-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5209-MONOMER BioCyc EcoCyc:EG12154-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12154-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL Z23096 http://www.ebi.ac.uk/ena/data/view/Z23096 EchoBASE EB2074 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2074 EcoGene EG12154 http://www.ecogene.org/geneInfo.php?eg_id=EG12154 EnsemblBacteria AAC74435 http://www.ensemblgenomes.org/id/AAC74435 EnsemblBacteria AAC74435 http://www.ensemblgenomes.org/id/AAC74435 EnsemblBacteria BAA14956 http://www.ensemblgenomes.org/id/BAA14956 EnsemblBacteria BAA14956 http://www.ensemblgenomes.org/id/BAA14956 EnsemblBacteria BAA14956 http://www.ensemblgenomes.org/id/BAA14956 EnsemblBacteria b1353 http://www.ensemblgenomes.org/id/b1353 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 945913 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945913 HOGENOM HOG000120187 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120187&db=HOGENOM6 InterPro IPR025982 http://www.ebi.ac.uk/interpro/entry/IPR025982 KEGG_Gene ecj:JW5209 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5209 KEGG_Gene eco:b1353 http://www.genome.jp/dbget-bin/www_bget?eco:b1353 OMA HIQKHFS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HIQKHFS PSORT swissprot:SIEB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SIEB_ECOLI PSORT-B swissprot:SIEB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SIEB_ECOLI PSORT2 swissprot:SIEB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SIEB_ECOLI Pfam PF14163 http://pfam.xfam.org/family/PF14163 Phobius swissprot:SIEB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SIEB_ECOLI ProteinModelPortal P38392 http://www.proteinmodelportal.org/query/uniprot/P38392 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7508908 http://www.ncbi.nlm.nih.gov/pubmed/7508908 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415870 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415870 RefSeq WP_001312793 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001312793 STRING 511145.b1353 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1353&targetmode=cogs UniProtKB SIEB_ECOLI http://www.uniprot.org/uniprot/SIEB_ECOLI UniProtKB-AC P38392 http://www.uniprot.org/uniprot/P38392 charge swissprot:SIEB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SIEB_ECOLI epestfind swissprot:SIEB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SIEB_ECOLI garnier swissprot:SIEB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SIEB_ECOLI helixturnhelix swissprot:SIEB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SIEB_ECOLI hmoment swissprot:SIEB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SIEB_ECOLI iep swissprot:SIEB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SIEB_ECOLI inforesidue swissprot:SIEB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SIEB_ECOLI octanol swissprot:SIEB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SIEB_ECOLI pepcoil swissprot:SIEB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SIEB_ECOLI pepdigest swissprot:SIEB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SIEB_ECOLI pepinfo swissprot:SIEB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SIEB_ECOLI pepnet swissprot:SIEB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SIEB_ECOLI pepstats swissprot:SIEB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SIEB_ECOLI pepwheel swissprot:SIEB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SIEB_ECOLI pepwindow swissprot:SIEB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SIEB_ECOLI sigcleave swissprot:SIEB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SIEB_ECOLI ## Database ID URL or Descriptions # AltName PYRB_ECOLI Aspartate transcarbamylase # BRENDA 2.1.3 2026 # BioGrid 4260722 10 # CATALYTIC ACTIVITY PYRB_ECOLI Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. # EcoGene EG10805 pyrB # GO_component GO:0005737 cytoplasm; IDA:UniProtKB. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004070 aspartate carbamoyltransferase activity; IBA:GO_Central. # GO_function GO:0016597 amino acid binding; IEA:InterPro. # GO_process GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro. # GO_process GO:0006520 cellular amino acid metabolic process; IEA:InterPro. # GO_process GO:0009220 pyrimidine ribonucleotide biosynthetic process; IBA:GO_Central. # GO_process GO:0044205 'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.1370 -; 2. # HAMAP MF_00001 Asp_carb_tr # INTERACTION PYRB_ECOLI P0A7F3 pyrI; NbExp=14; IntAct=EBI-906620, EBI-906630; # IntAct P0A786 3 # InterPro IPR002082 Asp_carbamoyltransf # InterPro IPR006130 Asp/Orn_carbamoylTrfase # InterPro IPR006131 Asp_carbamoyltransf_Asp/Orn-bd # InterPro IPR006132 Asp/Orn_carbamoyltranf_P-bd # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00240 Pyrimidine metabolism # KEGG_Pathway ko00250 Alanine, aspartate and glutamate metabolism # Organism PYRB_ECOLI Escherichia coli (strain K12) # PATHWAY Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate step 2/3. # PATRIC 32124067 VBIEscCol129921_4378 # PDB 1ACM X-ray; 2.80 A; A/C=2-311 # PDB 1AT1 X-ray; 2.80 A; A/C=2-311 # PDB 1D09 X-ray; 2.10 A; A/C=2-311 # PDB 1EKX X-ray; 1.95 A; A/B/C=1-311 # PDB 1EZZ X-ray; 2.70 A; A/C=2-311 # PDB 1F1B X-ray; 2.30 A; A/C=2-311 # PDB 1GQ3 X-ray; 2.01 A; A/B/C=2-311 # PDB 1I5O X-ray; 2.80 A; A/C=2-311 # PDB 1NBE X-ray; 2.60 A; A/C=2-311 # PDB 1Q95 X-ray; 2.46 A; A/B/C/D/E/F=2-311 # PDB 1R0B X-ray; 2.90 A; A/B/C/D/E/F=2-311 # PDB 1R0C X-ray; 2.37 A; A/G=2-311 # PDB 1RAA X-ray; 2.50 A; A/C=2-311 # PDB 1RAB X-ray; 2.50 A; A/C=2-311 # PDB 1RAC X-ray; 2.50 A; A/C=2-311 # PDB 1RAD X-ray; 2.50 A; A/C=2-311 # PDB 1RAE X-ray; 2.50 A; A/C=2-311 # PDB 1RAF X-ray; 2.50 A; A/C=2-311 # PDB 1RAG X-ray; 2.50 A; A/C=2-311 # PDB 1RAH X-ray; 2.50 A; A/C=2-311 # PDB 1RAI X-ray; 2.50 A; A/C=2-311 # PDB 1SKU X-ray; 2.60 A; A/C=2-311 # PDB 1TTH X-ray; 2.80 A; A/C=2-311 # PDB 1TU0 X-ray; 2.55 A; A/C=2-311 # PDB 1TUG X-ray; 2.10 A; A/C=2-311 # PDB 1XJW X-ray; 2.71 A; A/C=2-311 # PDB 1ZA1 X-ray; 2.20 A; A/C=2-311 # PDB 1ZA2 X-ray; 2.50 A; A/C=2-311 # PDB 2A0F X-ray; 2.90 A; A/C=2-311 # PDB 2AIR X-ray; 2.00 A; A/G=2-311 # PDB 2AT1 X-ray; 2.80 A; A/C=2-311 # PDB 2ATC X-ray; 3.00 A; A=2-311 # PDB 2FZC X-ray; 2.10 A; A/C=2-311 # PDB 2FZG X-ray; 2.25 A; A/C=2-311 # PDB 2FZK X-ray; 2.50 A; A/C=2-311 # PDB 2H3E X-ray; 2.30 A; A/C=2-311 # PDB 2HSE X-ray; 2.60 A; A/C=2-311 # PDB 2IPO X-ray; 2.60 A; A/C=2-311 # PDB 2QG9 X-ray; 2.70 A; A/C=2-311 # PDB 2QGF X-ray; 2.20 A; A/C=2-311 # PDB 3AT1 X-ray; 2.80 A; A/C=2-311 # PDB 3CSU X-ray; 1.88 A; A/B/C=2-311 # PDB 3D7S X-ray; 2.80 A; A/C=2-311 # PDB 3MPU X-ray; 2.86 A; A/C/E=2-311 # PDB 3NPM X-ray; 2.10 A; A=2-311 # PDB 4AT1 X-ray; 2.60 A; A/C=2-311 # PDB 4E2F X-ray; 2.80 A; A/C/E/G/I/K=2-311 # PDB 4F04 X-ray; 2.30 A; A/C=2-311 # PDB 4FYV X-ray; 2.10 A; A/C=2-311 # PDB 4FYW X-ray; 2.10 A; A/C=2-311 # PDB 4FYX X-ray; 2.09 A; A/C=2-311 # PDB 4FYY X-ray; 1.94 A; A/C=2-311 # PDB 4WTO X-ray; 2.03 A; A/C=2-311 # PDB 5AT1 X-ray; 2.60 A; A/C=2-311 # PDB 6AT1 X-ray; 2.60 A; A/C=2-311 # PDB 7AT1 X-ray; 2.80 A; A/C=2-311 # PDB 8AT1 X-ray; 2.80 A; A/C=2-311 # PDB 8ATC X-ray; 2.50 A; A/C=2-311 # PDB 9ATC X-ray; 2.40 A; A=2-311 # PIR H65236 DTECC # PRINTS PR00100 AOTCASE # PRINTS PR00101 ATCASE # PROSITE PS00097 CARBAMOYLTRANSFERASE # Pfam PF00185 OTCace # Pfam PF02729 OTCace_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PYRB_ECOLI Aspartate carbamoyltransferase catalytic chain # RefSeq NP_418666 NC_000913.3 # RefSeq WP_000013046 NZ_LN832404.1 # SIMILARITY Belongs to the ATCase/OTCase family. {ECO 0000305}. # SUBUNIT Heterododecamer (2C3:3R2) of six catalytic PyrB chains organized as two trimers (C3), and six regulatory PyrI chains organized as three dimers (R2). {ECO 0000269|PubMed:6377306}. # SUPFAM SSF53671 SSF53671 # TIGRFAMs TIGR00670 asp_carb_tr # UniPathway UPA00070 UER00116 # eggNOG COG0540 LUCA # eggNOG ENOG4105CXT Bacteria BLAST swissprot:PYRB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PYRB_ECOLI BioCyc ECOL316407:JW4204-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4204-MONOMER BioCyc EcoCyc:ASPCARBCAT-MONOMER http://biocyc.org/getid?id=EcoCyc:ASPCARBCAT-MONOMER BioCyc MetaCyc:ASPCARBCAT-MONOMER http://biocyc.org/getid?id=MetaCyc:ASPCARBCAT-MONOMER COG COG0540 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0540 DIP DIP-35089N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35089N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1002/elps.1150190539 http://dx.doi.org/10.1002/elps.1150190539 DOI 10.1021/bi00485a019 http://dx.doi.org/10.1021/bi00485a019 DOI 10.1021/bi00485a020 http://dx.doi.org/10.1021/bi00485a020 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.80.2.368 http://dx.doi.org/10.1073/pnas.80.2.368 DOI 10.1073/pnas.80.9.2462 http://dx.doi.org/10.1073/pnas.80.9.2462 DOI 10.1073/pnas.80.9.2467 http://dx.doi.org/10.1073/pnas.80.9.2467 DOI 10.1073/pnas.81.1.115 http://dx.doi.org/10.1073/pnas.81.1.115 DOI 10.1073/pnas.81.13.4037 http://dx.doi.org/10.1073/pnas.81.13.4037 DOI 10.1073/pnas.85.19.7149 http://dx.doi.org/10.1073/pnas.85.19.7149 DOI 10.1073/pnas.96.10.5388 http://dx.doi.org/10.1073/pnas.96.10.5388 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.3.2 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.3.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01670 http://www.ebi.ac.uk/ena/data/view/J01670 EMBL K01472 http://www.ebi.ac.uk/ena/data/view/K01472 EMBL M10743 http://www.ebi.ac.uk/ena/data/view/M10743 EMBL M60508 http://www.ebi.ac.uk/ena/data/view/M60508 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 2.1.3.2 http://enzyme.expasy.org/EC/2.1.3.2 EchoBASE EB0798 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0798 EcoGene EG10805 http://www.ecogene.org/geneInfo.php?eg_id=EG10805 EnsemblBacteria AAC77202 http://www.ensemblgenomes.org/id/AAC77202 EnsemblBacteria AAC77202 http://www.ensemblgenomes.org/id/AAC77202 EnsemblBacteria BAE78244 http://www.ensemblgenomes.org/id/BAE78244 EnsemblBacteria BAE78244 http://www.ensemblgenomes.org/id/BAE78244 EnsemblBacteria BAE78244 http://www.ensemblgenomes.org/id/BAE78244 EnsemblBacteria b4245 http://www.ensemblgenomes.org/id/b4245 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004070 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004070 GO_function GO:0016597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016597 GO_process GO:0006207 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006207 GO_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GO_process GO:0009220 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009220 GO_process GO:0044205 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044205 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.1370 http://www.cathdb.info/version/latest/superfamily/3.40.50.1370 GeneID 948767 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948767 HAMAP MF_00001 http://hamap.expasy.org/unirule/MF_00001 HOGENOM HOG000022685 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000022685&db=HOGENOM6 InParanoid P0A786 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A786 IntAct P0A786 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A786* IntEnz 2.1.3.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.3.2 InterPro IPR002082 http://www.ebi.ac.uk/interpro/entry/IPR002082 InterPro IPR006130 http://www.ebi.ac.uk/interpro/entry/IPR006130 InterPro IPR006131 http://www.ebi.ac.uk/interpro/entry/IPR006131 InterPro IPR006132 http://www.ebi.ac.uk/interpro/entry/IPR006132 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4204 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4204 KEGG_Gene eco:b4245 http://www.genome.jp/dbget-bin/www_bget?eco:b4245 KEGG_Orthology KO:K00609 http://www.genome.jp/dbget-bin/www_bget?KO:K00609 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Pathway ko00250 http://www.genome.jp/kegg-bin/show_pathway?ko00250 KEGG_Reaction rn:R01397 http://www.genome.jp/dbget-bin/www_bget?rn:R01397 MINT MINT-1541312 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1541312 OMA MHPGPMV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MHPGPMV PDB 1ACM http://www.ebi.ac.uk/pdbe-srv/view/entry/1ACM PDB 1AT1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1AT1 PDB 1D09 http://www.ebi.ac.uk/pdbe-srv/view/entry/1D09 PDB 1EKX http://www.ebi.ac.uk/pdbe-srv/view/entry/1EKX PDB 1EZZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1EZZ PDB 1F1B http://www.ebi.ac.uk/pdbe-srv/view/entry/1F1B PDB 1GQ3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1GQ3 PDB 1I5O http://www.ebi.ac.uk/pdbe-srv/view/entry/1I5O PDB 1NBE http://www.ebi.ac.uk/pdbe-srv/view/entry/1NBE PDB 1Q95 http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q95 PDB 1R0B http://www.ebi.ac.uk/pdbe-srv/view/entry/1R0B PDB 1R0C http://www.ebi.ac.uk/pdbe-srv/view/entry/1R0C PDB 1RAA http://www.ebi.ac.uk/pdbe-srv/view/entry/1RAA PDB 1RAB http://www.ebi.ac.uk/pdbe-srv/view/entry/1RAB PDB 1RAC http://www.ebi.ac.uk/pdbe-srv/view/entry/1RAC PDB 1RAD http://www.ebi.ac.uk/pdbe-srv/view/entry/1RAD PDB 1RAE http://www.ebi.ac.uk/pdbe-srv/view/entry/1RAE PDB 1RAF http://www.ebi.ac.uk/pdbe-srv/view/entry/1RAF PDB 1RAG http://www.ebi.ac.uk/pdbe-srv/view/entry/1RAG PDB 1RAH http://www.ebi.ac.uk/pdbe-srv/view/entry/1RAH PDB 1RAI http://www.ebi.ac.uk/pdbe-srv/view/entry/1RAI PDB 1SKU http://www.ebi.ac.uk/pdbe-srv/view/entry/1SKU PDB 1TTH http://www.ebi.ac.uk/pdbe-srv/view/entry/1TTH PDB 1TU0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1TU0 PDB 1TUG http://www.ebi.ac.uk/pdbe-srv/view/entry/1TUG PDB 1XJW http://www.ebi.ac.uk/pdbe-srv/view/entry/1XJW PDB 1ZA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZA1 PDB 1ZA2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZA2 PDB 2A0F http://www.ebi.ac.uk/pdbe-srv/view/entry/2A0F PDB 2AIR http://www.ebi.ac.uk/pdbe-srv/view/entry/2AIR PDB 2AT1 http://www.ebi.ac.uk/pdbe-srv/view/entry/2AT1 PDB 2ATC http://www.ebi.ac.uk/pdbe-srv/view/entry/2ATC PDB 2FZC http://www.ebi.ac.uk/pdbe-srv/view/entry/2FZC PDB 2FZG http://www.ebi.ac.uk/pdbe-srv/view/entry/2FZG PDB 2FZK http://www.ebi.ac.uk/pdbe-srv/view/entry/2FZK PDB 2H3E http://www.ebi.ac.uk/pdbe-srv/view/entry/2H3E PDB 2HSE http://www.ebi.ac.uk/pdbe-srv/view/entry/2HSE PDB 2IPO http://www.ebi.ac.uk/pdbe-srv/view/entry/2IPO PDB 2QG9 http://www.ebi.ac.uk/pdbe-srv/view/entry/2QG9 PDB 2QGF http://www.ebi.ac.uk/pdbe-srv/view/entry/2QGF PDB 3AT1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3AT1 PDB 3CSU http://www.ebi.ac.uk/pdbe-srv/view/entry/3CSU PDB 3D7S http://www.ebi.ac.uk/pdbe-srv/view/entry/3D7S PDB 3MPU http://www.ebi.ac.uk/pdbe-srv/view/entry/3MPU PDB 3NPM http://www.ebi.ac.uk/pdbe-srv/view/entry/3NPM PDB 4AT1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4AT1 PDB 4E2F http://www.ebi.ac.uk/pdbe-srv/view/entry/4E2F PDB 4F04 http://www.ebi.ac.uk/pdbe-srv/view/entry/4F04 PDB 4FYV http://www.ebi.ac.uk/pdbe-srv/view/entry/4FYV PDB 4FYW http://www.ebi.ac.uk/pdbe-srv/view/entry/4FYW PDB 4FYX http://www.ebi.ac.uk/pdbe-srv/view/entry/4FYX PDB 4FYY http://www.ebi.ac.uk/pdbe-srv/view/entry/4FYY PDB 4WTO http://www.ebi.ac.uk/pdbe-srv/view/entry/4WTO PDB 5AT1 http://www.ebi.ac.uk/pdbe-srv/view/entry/5AT1 PDB 6AT1 http://www.ebi.ac.uk/pdbe-srv/view/entry/6AT1 PDB 7AT1 http://www.ebi.ac.uk/pdbe-srv/view/entry/7AT1 PDB 8AT1 http://www.ebi.ac.uk/pdbe-srv/view/entry/8AT1 PDB 8ATC http://www.ebi.ac.uk/pdbe-srv/view/entry/8ATC PDB 9ATC http://www.ebi.ac.uk/pdbe-srv/view/entry/9ATC PDBsum 1ACM http://www.ebi.ac.uk/pdbsum/1ACM PDBsum 1AT1 http://www.ebi.ac.uk/pdbsum/1AT1 PDBsum 1D09 http://www.ebi.ac.uk/pdbsum/1D09 PDBsum 1EKX http://www.ebi.ac.uk/pdbsum/1EKX PDBsum 1EZZ http://www.ebi.ac.uk/pdbsum/1EZZ PDBsum 1F1B http://www.ebi.ac.uk/pdbsum/1F1B PDBsum 1GQ3 http://www.ebi.ac.uk/pdbsum/1GQ3 PDBsum 1I5O http://www.ebi.ac.uk/pdbsum/1I5O PDBsum 1NBE http://www.ebi.ac.uk/pdbsum/1NBE PDBsum 1Q95 http://www.ebi.ac.uk/pdbsum/1Q95 PDBsum 1R0B http://www.ebi.ac.uk/pdbsum/1R0B PDBsum 1R0C http://www.ebi.ac.uk/pdbsum/1R0C PDBsum 1RAA http://www.ebi.ac.uk/pdbsum/1RAA PDBsum 1RAB http://www.ebi.ac.uk/pdbsum/1RAB PDBsum 1RAC http://www.ebi.ac.uk/pdbsum/1RAC PDBsum 1RAD http://www.ebi.ac.uk/pdbsum/1RAD PDBsum 1RAE http://www.ebi.ac.uk/pdbsum/1RAE PDBsum 1RAF http://www.ebi.ac.uk/pdbsum/1RAF PDBsum 1RAG http://www.ebi.ac.uk/pdbsum/1RAG PDBsum 1RAH http://www.ebi.ac.uk/pdbsum/1RAH PDBsum 1RAI http://www.ebi.ac.uk/pdbsum/1RAI PDBsum 1SKU http://www.ebi.ac.uk/pdbsum/1SKU PDBsum 1TTH http://www.ebi.ac.uk/pdbsum/1TTH PDBsum 1TU0 http://www.ebi.ac.uk/pdbsum/1TU0 PDBsum 1TUG http://www.ebi.ac.uk/pdbsum/1TUG PDBsum 1XJW http://www.ebi.ac.uk/pdbsum/1XJW PDBsum 1ZA1 http://www.ebi.ac.uk/pdbsum/1ZA1 PDBsum 1ZA2 http://www.ebi.ac.uk/pdbsum/1ZA2 PDBsum 2A0F http://www.ebi.ac.uk/pdbsum/2A0F PDBsum 2AIR http://www.ebi.ac.uk/pdbsum/2AIR PDBsum 2AT1 http://www.ebi.ac.uk/pdbsum/2AT1 PDBsum 2ATC http://www.ebi.ac.uk/pdbsum/2ATC PDBsum 2FZC http://www.ebi.ac.uk/pdbsum/2FZC PDBsum 2FZG http://www.ebi.ac.uk/pdbsum/2FZG PDBsum 2FZK http://www.ebi.ac.uk/pdbsum/2FZK PDBsum 2H3E http://www.ebi.ac.uk/pdbsum/2H3E PDBsum 2HSE http://www.ebi.ac.uk/pdbsum/2HSE PDBsum 2IPO http://www.ebi.ac.uk/pdbsum/2IPO PDBsum 2QG9 http://www.ebi.ac.uk/pdbsum/2QG9 PDBsum 2QGF http://www.ebi.ac.uk/pdbsum/2QGF PDBsum 3AT1 http://www.ebi.ac.uk/pdbsum/3AT1 PDBsum 3CSU http://www.ebi.ac.uk/pdbsum/3CSU PDBsum 3D7S http://www.ebi.ac.uk/pdbsum/3D7S PDBsum 3MPU http://www.ebi.ac.uk/pdbsum/3MPU PDBsum 3NPM http://www.ebi.ac.uk/pdbsum/3NPM PDBsum 4AT1 http://www.ebi.ac.uk/pdbsum/4AT1 PDBsum 4E2F http://www.ebi.ac.uk/pdbsum/4E2F PDBsum 4F04 http://www.ebi.ac.uk/pdbsum/4F04 PDBsum 4FYV http://www.ebi.ac.uk/pdbsum/4FYV PDBsum 4FYW http://www.ebi.ac.uk/pdbsum/4FYW PDBsum 4FYX http://www.ebi.ac.uk/pdbsum/4FYX PDBsum 4FYY http://www.ebi.ac.uk/pdbsum/4FYY PDBsum 4WTO http://www.ebi.ac.uk/pdbsum/4WTO PDBsum 5AT1 http://www.ebi.ac.uk/pdbsum/5AT1 PDBsum 6AT1 http://www.ebi.ac.uk/pdbsum/6AT1 PDBsum 7AT1 http://www.ebi.ac.uk/pdbsum/7AT1 PDBsum 8AT1 http://www.ebi.ac.uk/pdbsum/8AT1 PDBsum 8ATC http://www.ebi.ac.uk/pdbsum/8ATC PDBsum 9ATC http://www.ebi.ac.uk/pdbsum/9ATC PRINTS PR00100 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00100 PRINTS PR00101 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00101 PROSITE PS00097 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00097 PSORT swissprot:PYRB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PYRB_ECOLI PSORT-B swissprot:PYRB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PYRB_ECOLI PSORT2 swissprot:PYRB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PYRB_ECOLI Pfam PF00185 http://pfam.xfam.org/family/PF00185 Pfam PF02729 http://pfam.xfam.org/family/PF02729 Phobius swissprot:PYRB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PYRB_ECOLI PhylomeDB P0A786 http://phylomedb.org/?seqid=P0A786 ProteinModelPortal P0A786 http://www.proteinmodelportal.org/query/uniprot/P0A786 PubMed 10318893 http://www.ncbi.nlm.nih.gov/pubmed/10318893 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1699940 http://www.ncbi.nlm.nih.gov/pubmed/1699940 PubMed 2271528 http://www.ncbi.nlm.nih.gov/pubmed/2271528 PubMed 2271529 http://www.ncbi.nlm.nih.gov/pubmed/2271529 PubMed 2459698 http://www.ncbi.nlm.nih.gov/pubmed/2459698 PubMed 3928602 http://www.ncbi.nlm.nih.gov/pubmed/3928602 PubMed 6300835 http://www.ncbi.nlm.nih.gov/pubmed/6300835 PubMed 6302686 http://www.ncbi.nlm.nih.gov/pubmed/6302686 PubMed 6341995 http://www.ncbi.nlm.nih.gov/pubmed/6341995 PubMed 6364131 http://www.ncbi.nlm.nih.gov/pubmed/6364131 PubMed 6377306 http://www.ncbi.nlm.nih.gov/pubmed/6377306 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9629924 http://www.ncbi.nlm.nih.gov/pubmed/9629924 RefSeq NP_418666 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418666 RefSeq WP_000013046 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000013046 SMR P0A786 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A786 STRING 511145.b4245 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4245&targetmode=cogs STRING COG0540 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0540&targetmode=cogs SUPFAM SSF53671 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53671 SWISS-2DPAGE P0A786 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A786 TIGRFAMs TIGR00670 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00670 UniProtKB PYRB_ECOLI http://www.uniprot.org/uniprot/PYRB_ECOLI UniProtKB-AC P0A786 http://www.uniprot.org/uniprot/P0A786 charge swissprot:PYRB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PYRB_ECOLI eggNOG COG0540 http://eggnogapi.embl.de/nog_data/html/tree/COG0540 eggNOG ENOG4105CXT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CXT epestfind swissprot:PYRB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PYRB_ECOLI garnier swissprot:PYRB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PYRB_ECOLI helixturnhelix swissprot:PYRB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PYRB_ECOLI hmoment swissprot:PYRB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PYRB_ECOLI iep swissprot:PYRB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PYRB_ECOLI inforesidue swissprot:PYRB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PYRB_ECOLI octanol swissprot:PYRB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PYRB_ECOLI pepcoil swissprot:PYRB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PYRB_ECOLI pepdigest swissprot:PYRB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PYRB_ECOLI pepinfo swissprot:PYRB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PYRB_ECOLI pepnet swissprot:PYRB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PYRB_ECOLI pepstats swissprot:PYRB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PYRB_ECOLI pepwheel swissprot:PYRB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PYRB_ECOLI pepwindow swissprot:PYRB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PYRB_ECOLI sigcleave swissprot:PYRB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PYRB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260246 30 # EcoGene EG10228 dicC # FUNCTION DICC_ECOLI This protein is a repressor of division inhibition gene dicB. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0007049 cell cycle; IEA:UniProtKB-KW. # GO_process GO:0051301 cell division; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0007049 cell cycle # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0051301 cell division # Gene3D 1.10.260.40 -; 1. # IntAct P06965 7 # InterPro IPR010982 Lambda_DNA-bd_dom # Organism DICC_ECOLI Escherichia coli (strain K12) # PATRIC 32118440 VBIEscCol129921_1640 # PIR A24328 CEECDC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DICC_ECOLI Repressor protein of division inhibition gene dicB # RefSeq NP_416087 NC_000913.3 # RefSeq WP_000920568 NZ_LN832404.1 # SUPFAM SSF47413 SSF47413 BLAST swissprot:DICC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DICC_ECOLI BioCyc ECOL316407:JW1561-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1561-MONOMER BioCyc EcoCyc:EG10228-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10228-MONOMER DOI 10.1007/BF00322439 http://dx.doi.org/10.1007/BF00322439 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/14.17.6821 http://dx.doi.org/10.1093/nar/14.17.6821 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X07465 http://www.ebi.ac.uk/ena/data/view/X07465 EchoBASE EB0224 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0224 EcoGene EG10228 http://www.ecogene.org/geneInfo.php?eg_id=EG10228 EnsemblBacteria AAC74642 http://www.ensemblgenomes.org/id/AAC74642 EnsemblBacteria AAC74642 http://www.ensemblgenomes.org/id/AAC74642 EnsemblBacteria BAA15274 http://www.ensemblgenomes.org/id/BAA15274 EnsemblBacteria BAA15274 http://www.ensemblgenomes.org/id/BAA15274 EnsemblBacteria BAA15274 http://www.ensemblgenomes.org/id/BAA15274 EnsemblBacteria b1569 http://www.ensemblgenomes.org/id/b1569 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 Gene3D 1.10.260.40 http://www.cathdb.info/version/latest/superfamily/1.10.260.40 GeneID 946120 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946120 HOGENOM HOG000119879 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000119879&db=HOGENOM6 IntAct P06965 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P06965* InterPro IPR010982 http://www.ebi.ac.uk/interpro/entry/IPR010982 KEGG_Gene ecj:JW1561 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1561 KEGG_Gene eco:b1569 http://www.genome.jp/dbget-bin/www_bget?eco:b1569 PSORT swissprot:DICC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DICC_ECOLI PSORT-B swissprot:DICC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DICC_ECOLI PSORT2 swissprot:DICC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DICC_ECOLI Phobius swissprot:DICC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DICC_ECOLI ProteinModelPortal P06965 http://www.proteinmodelportal.org/query/uniprot/P06965 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2836697 http://www.ncbi.nlm.nih.gov/pubmed/2836697 PubMed 3532030 http://www.ncbi.nlm.nih.gov/pubmed/3532030 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416087 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416087 RefSeq WP_000920568 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000920568 SMR P06965 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P06965 STRING 511145.b1569 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1569&targetmode=cogs SUPFAM SSF47413 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47413 UniProtKB DICC_ECOLI http://www.uniprot.org/uniprot/DICC_ECOLI UniProtKB-AC P06965 http://www.uniprot.org/uniprot/P06965 charge swissprot:DICC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DICC_ECOLI epestfind swissprot:DICC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DICC_ECOLI garnier swissprot:DICC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DICC_ECOLI helixturnhelix swissprot:DICC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DICC_ECOLI hmoment swissprot:DICC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DICC_ECOLI iep swissprot:DICC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DICC_ECOLI inforesidue swissprot:DICC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DICC_ECOLI octanol swissprot:DICC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DICC_ECOLI pepcoil swissprot:DICC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DICC_ECOLI pepdigest swissprot:DICC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DICC_ECOLI pepinfo swissprot:DICC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DICC_ECOLI pepnet swissprot:DICC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DICC_ECOLI pepstats swissprot:DICC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DICC_ECOLI pepwheel swissprot:DICC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DICC_ECOLI pepwindow swissprot:DICC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DICC_ECOLI sigcleave swissprot:DICC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DICC_ECOLI ## Database ID URL or Descriptions # BioGrid 4260668 11 # CDD cd01392 HTH_LacI # EcoGene EG10525 lacI # FUNCTION LACI_ECOLI Repressor of the lactose operon. Binds allolactose as an inducer. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0000986 bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding; IDA:EcoCyc. # GO_function GO:0001141 transcriptional repressor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.260.40 -; 1. # IntAct P03023 6 # InterPro IPR000843 HTH_LacI # InterPro IPR010982 Lambda_DNA-bd_dom # InterPro IPR028082 Peripla_BP_I # MISCELLANEOUS LACI_ECOLI Removing residues 1-59 results in loss of DNA- binding activity but retains tetrameric structure and inducer- binding activity. Deleting residues 340-360 results in loss of tetramer formation, but retains dimer formation, inducer-binding activity, and DNA-binding activity (if residues 1-59 are present). # Organism LACI_ECOLI Escherichia coli (strain K12) # PATRIC 32115823 VBIEscCol129921_0353 # PDB 1CJG NMR; -; A/B=1-62 # PDB 1EFA X-ray; 2.60 A; A/B/C=1-333 # PDB 1JWL X-ray; 4.00 A; A/B/C=1-333 # PDB 1JYE X-ray; 1.70 A; A=1-349 # PDB 1JYF X-ray; 3.00 A; A=1-349 # PDB 1L1M NMR; -; A/B=1-62 # PDB 1LBG X-ray; 4.80 A; A/B/C/D=1-360 # PDB 1LBH X-ray; 3.20 A; A/B/C/D=1-360 # PDB 1LBI X-ray; 2.70 A; A/B/C/D=1-360 # PDB 1LCC NMR; -; A=1-51 # PDB 1LCD NMR; -; A=1-51 # PDB 1LQC NMR; -; A=1-56 # PDB 1LTP Model; -; L=62-323 # PDB 1OSL NMR; -; A/B=1-62 # PDB 1TLF X-ray; 2.60 A; A/B/C/D=60-360 # PDB 1Z04 Model; -; A/B/C/D=1-357 # PDB 2BJC NMR; -; A/B=1-62 # PDB 2KEI NMR; -; A/B=1-62 # PDB 2KEJ NMR; -; A/B=1-62 # PDB 2KEK NMR; -; A/B=1-62 # PDB 2P9H X-ray; 2.00 A; A/B=62-330 # PDB 2PAF X-ray; 3.50 A; A/B=62-330 # PDB 2PE5 X-ray; 3.50 A; A/B/C=2-331 # PDB 3EDC X-ray; 2.10 A; A/B/C/D=1-360 # PDB 4RZS X-ray; 2.71 A; A/B/C/D=2-360 # PDB 4RZT X-ray; 3.10 A; A/B/C/D=2-360 # PIR A93198 RPECL # PRINTS PR00036 HTHLACI # PROSITE PS00356 HTH_LACI_1 # PROSITE PS50932 HTH_LACI_2 # Pfam PF00356 LacI # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LACI_ECOLI Lactose operon repressor # RefSeq NP_414879 NC_000913.3 # RefSeq WP_000805902 NZ_CP014272.1 # SEQUENCE CAUTION Sequence=AAB18069.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAB47270.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Contains 1 HTH lacI-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00111}. # SMART SM00354 HTH_LACI # SUBUNIT LACI_ECOLI Homotetramer. # SUPFAM SSF47413 SSF47413 # SUPFAM SSF53822 SSF53822 # eggNOG COG1609 LUCA # eggNOG ENOG4105ETE Bacteria BLAST swissprot:LACI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LACI_ECOLI BioCyc ECOL316407:JW0336-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0336-MONOMER BioCyc EcoCyc:PD00763 http://biocyc.org/getid?id=EcoCyc:PD00763 DIP DIP-10079N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10079N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/jmbi.1994.1458 http://dx.doi.org/10.1006/jmbi.1994.1458 DOI 10.1006/jmbi.1996.0356 http://dx.doi.org/10.1006/jmbi.1996.0356 DOI 10.1016/0014-5793(95)01153-6 http://dx.doi.org/10.1016/0014-5793(95)01153-6 DOI 10.1016/0022-2836(88)90237-9 http://dx.doi.org/10.1016/0022-2836(88)90237-9 DOI 10.1016/S0969-2126(00)88339-2 http://dx.doi.org/10.1016/S0969-2126(00)88339-2 DOI 10.1021/bi00433a037 http://dx.doi.org/10.1021/bi00433a037 DOI 10.1038/274765a0 http://dx.doi.org/10.1038/274765a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.70.11.3165 http://dx.doi.org/10.1073/pnas.70.11.3165 DOI 10.1093/nar/19.19.5233 http://dx.doi.org/10.1093/nar/19.19.5233 DOI 10.1111/j.1432-1033.1975.tb02477.x http://dx.doi.org/10.1111/j.1432-1033.1975.tb02477.x DOI 10.1111/j.1432-1033.1991.tb16030.x http://dx.doi.org/10.1111/j.1432-1033.1991.tb16030.x DOI 10.1126/science.271.5253.1247 http://dx.doi.org/10.1126/science.271.5253.1247 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DisProt DP00433 http://www.disprot.org/protein.php?id=DP00433 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01636 http://www.ebi.ac.uk/ena/data/view/J01636 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U72488 http://www.ebi.ac.uk/ena/data/view/U72488 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EMBL U78872 http://www.ebi.ac.uk/ena/data/view/U78872 EMBL U78873 http://www.ebi.ac.uk/ena/data/view/U78873 EMBL U78874 http://www.ebi.ac.uk/ena/data/view/U78874 EMBL U86347 http://www.ebi.ac.uk/ena/data/view/U86347 EMBL V00294 http://www.ebi.ac.uk/ena/data/view/V00294 EMBL X58469 http://www.ebi.ac.uk/ena/data/view/X58469 EchoBASE EB0520 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0520 EcoGene EG10525 http://www.ecogene.org/geneInfo.php?eg_id=EG10525 EnsemblBacteria AAC73448 http://www.ensemblgenomes.org/id/AAC73448 EnsemblBacteria AAC73448 http://www.ensemblgenomes.org/id/AAC73448 EnsemblBacteria BAE76127 http://www.ensemblgenomes.org/id/BAE76127 EnsemblBacteria BAE76127 http://www.ensemblgenomes.org/id/BAE76127 EnsemblBacteria BAE76127 http://www.ensemblgenomes.org/id/BAE76127 EnsemblBacteria b0345 http://www.ensemblgenomes.org/id/b0345 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000986 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000986 GO_function GO:0001141 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001141 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.260.40 http://www.cathdb.info/version/latest/superfamily/1.10.260.40 GeneID 945007 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945007 HOGENOM HOG000220179 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220179&db=HOGENOM6 InParanoid P03023 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P03023 IntAct P03023 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P03023* InterPro IPR000843 http://www.ebi.ac.uk/interpro/entry/IPR000843 InterPro IPR010982 http://www.ebi.ac.uk/interpro/entry/IPR010982 InterPro IPR028082 http://www.ebi.ac.uk/interpro/entry/IPR028082 KEGG_Gene ecj:JW0336 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0336 KEGG_Gene eco:b0345 http://www.genome.jp/dbget-bin/www_bget?eco:b0345 MINT MINT-6478062 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-6478062 OMA YDVANHA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YDVANHA PDB 1CJG http://www.ebi.ac.uk/pdbe-srv/view/entry/1CJG PDB 1EFA http://www.ebi.ac.uk/pdbe-srv/view/entry/1EFA PDB 1JWL http://www.ebi.ac.uk/pdbe-srv/view/entry/1JWL PDB 1JYE http://www.ebi.ac.uk/pdbe-srv/view/entry/1JYE PDB 1JYF http://www.ebi.ac.uk/pdbe-srv/view/entry/1JYF PDB 1L1M http://www.ebi.ac.uk/pdbe-srv/view/entry/1L1M PDB 1LBG http://www.ebi.ac.uk/pdbe-srv/view/entry/1LBG PDB 1LBH http://www.ebi.ac.uk/pdbe-srv/view/entry/1LBH PDB 1LBI http://www.ebi.ac.uk/pdbe-srv/view/entry/1LBI PDB 1LCC http://www.ebi.ac.uk/pdbe-srv/view/entry/1LCC PDB 1LCD http://www.ebi.ac.uk/pdbe-srv/view/entry/1LCD PDB 1LQC http://www.ebi.ac.uk/pdbe-srv/view/entry/1LQC PDB 1LTP http://www.ebi.ac.uk/pdbe-srv/view/entry/1LTP PDB 1OSL http://www.ebi.ac.uk/pdbe-srv/view/entry/1OSL PDB 1TLF http://www.ebi.ac.uk/pdbe-srv/view/entry/1TLF PDB 1Z04 http://www.ebi.ac.uk/pdbe-srv/view/entry/1Z04 PDB 2BJC http://www.ebi.ac.uk/pdbe-srv/view/entry/2BJC PDB 2KEI http://www.ebi.ac.uk/pdbe-srv/view/entry/2KEI PDB 2KEJ http://www.ebi.ac.uk/pdbe-srv/view/entry/2KEJ PDB 2KEK http://www.ebi.ac.uk/pdbe-srv/view/entry/2KEK PDB 2P9H http://www.ebi.ac.uk/pdbe-srv/view/entry/2P9H PDB 2PAF http://www.ebi.ac.uk/pdbe-srv/view/entry/2PAF PDB 2PE5 http://www.ebi.ac.uk/pdbe-srv/view/entry/2PE5 PDB 3EDC http://www.ebi.ac.uk/pdbe-srv/view/entry/3EDC PDB 4RZS http://www.ebi.ac.uk/pdbe-srv/view/entry/4RZS PDB 4RZT http://www.ebi.ac.uk/pdbe-srv/view/entry/4RZT PDBsum 1CJG http://www.ebi.ac.uk/pdbsum/1CJG PDBsum 1EFA http://www.ebi.ac.uk/pdbsum/1EFA PDBsum 1JWL http://www.ebi.ac.uk/pdbsum/1JWL PDBsum 1JYE http://www.ebi.ac.uk/pdbsum/1JYE PDBsum 1JYF http://www.ebi.ac.uk/pdbsum/1JYF PDBsum 1L1M http://www.ebi.ac.uk/pdbsum/1L1M PDBsum 1LBG http://www.ebi.ac.uk/pdbsum/1LBG PDBsum 1LBH http://www.ebi.ac.uk/pdbsum/1LBH PDBsum 1LBI http://www.ebi.ac.uk/pdbsum/1LBI PDBsum 1LCC http://www.ebi.ac.uk/pdbsum/1LCC PDBsum 1LCD http://www.ebi.ac.uk/pdbsum/1LCD PDBsum 1LQC http://www.ebi.ac.uk/pdbsum/1LQC PDBsum 1LTP http://www.ebi.ac.uk/pdbsum/1LTP PDBsum 1OSL http://www.ebi.ac.uk/pdbsum/1OSL PDBsum 1TLF http://www.ebi.ac.uk/pdbsum/1TLF PDBsum 1Z04 http://www.ebi.ac.uk/pdbsum/1Z04 PDBsum 2BJC http://www.ebi.ac.uk/pdbsum/2BJC PDBsum 2KEI http://www.ebi.ac.uk/pdbsum/2KEI PDBsum 2KEJ http://www.ebi.ac.uk/pdbsum/2KEJ PDBsum 2KEK http://www.ebi.ac.uk/pdbsum/2KEK PDBsum 2P9H http://www.ebi.ac.uk/pdbsum/2P9H PDBsum 2PAF http://www.ebi.ac.uk/pdbsum/2PAF PDBsum 2PE5 http://www.ebi.ac.uk/pdbsum/2PE5 PDBsum 3EDC http://www.ebi.ac.uk/pdbsum/3EDC PDBsum 4RZS http://www.ebi.ac.uk/pdbsum/4RZS PDBsum 4RZT http://www.ebi.ac.uk/pdbsum/4RZT PRINTS PR00036 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00036 PROSITE PS00356 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00356 PROSITE PS50932 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50932 PSORT swissprot:LACI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LACI_ECOLI PSORT-B swissprot:LACI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LACI_ECOLI PSORT2 swissprot:LACI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LACI_ECOLI Pfam PF00356 http://pfam.xfam.org/family/PF00356 Phobius swissprot:LACI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LACI_ECOLI PhylomeDB P03023 http://phylomedb.org/?seqid=P03023 ProteinModelPortal P03023 http://www.proteinmodelportal.org/query/uniprot/P03023 PubMed 10647179 http://www.ncbi.nlm.nih.gov/pubmed/10647179 PubMed 1107032 http://www.ncbi.nlm.nih.gov/pubmed/1107032 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1923807 http://www.ncbi.nlm.nih.gov/pubmed/1923807 PubMed 2040302 http://www.ncbi.nlm.nih.gov/pubmed/2040302 PubMed 2178920 http://www.ncbi.nlm.nih.gov/pubmed/2178920 PubMed 2742823 http://www.ncbi.nlm.nih.gov/pubmed/2742823 PubMed 3064080 http://www.ncbi.nlm.nih.gov/pubmed/3064080 PubMed 3286877 http://www.ncbi.nlm.nih.gov/pubmed/3286877 PubMed 355891 http://www.ncbi.nlm.nih.gov/pubmed/355891 PubMed 4571224 http://www.ncbi.nlm.nih.gov/pubmed/4571224 PubMed 4594037 http://www.ncbi.nlm.nih.gov/pubmed/4594037 PubMed 7498473 http://www.ncbi.nlm.nih.gov/pubmed/7498473 PubMed 8046748 http://www.ncbi.nlm.nih.gov/pubmed/8046748 PubMed 8638105 http://www.ncbi.nlm.nih.gov/pubmed/8638105 PubMed 8683581 http://www.ncbi.nlm.nih.gov/pubmed/8683581 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_414879 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414879 RefSeq WP_000805902 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000805902 SMART SM00354 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00354 SMR P03023 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P03023 STRING 511145.b0345 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0345&targetmode=cogs SUPFAM SSF47413 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47413 SUPFAM SSF53822 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822 UniProtKB LACI_ECOLI http://www.uniprot.org/uniprot/LACI_ECOLI UniProtKB-AC P03023 http://www.uniprot.org/uniprot/P03023 charge swissprot:LACI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LACI_ECOLI eggNOG COG1609 http://eggnogapi.embl.de/nog_data/html/tree/COG1609 eggNOG ENOG4105ETE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ETE epestfind swissprot:LACI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LACI_ECOLI garnier swissprot:LACI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LACI_ECOLI helixturnhelix swissprot:LACI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LACI_ECOLI hmoment swissprot:LACI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LACI_ECOLI iep swissprot:LACI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LACI_ECOLI inforesidue swissprot:LACI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LACI_ECOLI octanol swissprot:LACI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LACI_ECOLI pepcoil swissprot:LACI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LACI_ECOLI pepdigest swissprot:LACI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LACI_ECOLI pepinfo swissprot:LACI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LACI_ECOLI pepnet swissprot:LACI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LACI_ECOLI pepstats swissprot:LACI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LACI_ECOLI pepwheel swissprot:LACI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LACI_ECOLI pepwindow swissprot:LACI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LACI_ECOLI sigcleave swissprot:LACI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LACI_ECOLI ## Database ID URL or Descriptions # BRENDA 2.5.1 2026 # CATALYTIC ACTIVITY 2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine. {ECO:0000269|PubMed 9022701}. # DrugBank DB00140 Riboflavin # EcoGene EG11406 ribC # FUNCTION RISA_ECOLI Catalyzes the dismutation of two molecules of 6,7- dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil. {ECO 0000269|PubMed 9022701}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004746 riboflavin synthase activity; IDA:EcoCyc. # GO_function GO:0016491 oxidoreductase activity; IEA:InterPro. # GO_process GO:0009231 riboflavin biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 2.40.30.20 -; 2. # IntAct P0AFU8 3 # InterPro IPR001783 Lumazine-bd # InterPro IPR017938 Riboflavin_synthase-like_b-brl # InterPro IPR023366 ATP_synth_asu-like # InterPro IPR026017 Lumazine-bd_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00740 Riboflavin metabolism # Organism RISA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21098 PTHR21098 # PATHWAY Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D- ribitylamino)uracil step 2/2. # PATRIC 32118630 VBIEscCol129921_1735 # PDB 1HZE NMR; -; A/B=1-97 # PDB 1I18 NMR; -; A/B=1-97 # PDB 1I8D X-ray; 2.00 A; A/B/C=1-213 # PDB 1PKV X-ray; 2.60 A; A/B=1-97 # PIR S28526 S28526 # PIRSF PIRSF000498 Riboflavin_syn_A # PROSITE PS51177 LUMAZINE_BIND; 2 # Pfam PF00677 Lum_binding; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RISA_ECOLI Riboflavin synthase # RefSeq NP_416179 NC_000913.3 # RefSeq WP_000493947 NZ_LN832404.1 # SIMILARITY Contains 2 lumazine-binding repeats. {ECO:0000255|PROSITE-ProRule PRU00524}. # SUBUNIT RISA_ECOLI Homotrimer. Unlike in B.subtilis, does not interact with 6,7-dimethyl-8-ribityllumazine synthase. {ECO 0000269|PubMed 11399071, ECO 0000269|PubMed 12927541, ECO 0000269|PubMed 9022701}. # SUPFAM SSF63380 SSF63380; 2 # TIGRFAMs TIGR00187 ribE # UniPathway UPA00275 UER00405 # eggNOG COG0307 LUCA # eggNOG ENOG4108R6K Bacteria BLAST swissprot:RISA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RISA_ECOLI BioCyc ECOL316407:JW1654-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1654-MONOMER BioCyc EcoCyc:RIBOFLAVIN-SYN-MONOMER http://biocyc.org/getid?id=EcoCyc:RIBOFLAVIN-SYN-MONOMER BioCyc MetaCyc:RIBOFLAVIN-SYN-MONOMER http://biocyc.org/getid?id=MetaCyc:RIBOFLAVIN-SYN-MONOMER COG COG0307 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0307 DIP DIP-47865N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47865N DOI 10.1006/jmbi.2001.4683 http://dx.doi.org/10.1006/jmbi.2001.4683 DOI 10.1016/S0022-2836(03)00844-1 http://dx.doi.org/10.1016/S0022-2836(03)00844-1 DOI 10.1016/S0969-2126(01)00600-1 http://dx.doi.org/10.1016/S0969-2126(01)00600-1 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1111/j.1432-1033.1996.0712r.x http://dx.doi.org/10.1111/j.1432-1033.1996.0712r.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB00140 http://www.drugbank.ca/drugs/DB00140 EC_number EC:2.5.1.9 http://www.genome.jp/dbget-bin/www_bget?EC:2.5.1.9 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U68703 http://www.ebi.ac.uk/ena/data/view/U68703 EMBL X69109 http://www.ebi.ac.uk/ena/data/view/X69109 ENZYME 2.5.1.9 http://enzyme.expasy.org/EC/2.5.1.9 EchoBASE EB1378 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1378 EcoGene EG11406 http://www.ecogene.org/geneInfo.php?eg_id=EG11406 EnsemblBacteria AAC74734 http://www.ensemblgenomes.org/id/AAC74734 EnsemblBacteria AAC74734 http://www.ensemblgenomes.org/id/AAC74734 EnsemblBacteria BAA15429 http://www.ensemblgenomes.org/id/BAA15429 EnsemblBacteria BAA15429 http://www.ensemblgenomes.org/id/BAA15429 EnsemblBacteria BAA15429 http://www.ensemblgenomes.org/id/BAA15429 EnsemblBacteria b1662 http://www.ensemblgenomes.org/id/b1662 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004746 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_process GO:0009231 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009231 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016765 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 2.40.30.20 http://www.cathdb.info/version/latest/superfamily/2.40.30.20 GeneID 945848 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945848 HOGENOM HOG000151758 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000151758&db=HOGENOM6 InParanoid P0AFU8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFU8 IntAct P0AFU8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFU8* IntEnz 2.5.1.9 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.5.1.9 InterPro IPR001783 http://www.ebi.ac.uk/interpro/entry/IPR001783 InterPro IPR017938 http://www.ebi.ac.uk/interpro/entry/IPR017938 InterPro IPR023366 http://www.ebi.ac.uk/interpro/entry/IPR023366 InterPro IPR026017 http://www.ebi.ac.uk/interpro/entry/IPR026017 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1654 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1654 KEGG_Gene eco:b1662 http://www.genome.jp/dbget-bin/www_bget?eco:b1662 KEGG_Orthology KO:K00793 http://www.genome.jp/dbget-bin/www_bget?KO:K00793 KEGG_Pathway ko00740 http://www.genome.jp/kegg-bin/show_pathway?ko00740 KEGG_Reaction rn:R00066 http://www.genome.jp/dbget-bin/www_bget?rn:R00066 OMA HILSGHV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HILSGHV PANTHER PTHR21098 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21098 PDB 1HZE http://www.ebi.ac.uk/pdbe-srv/view/entry/1HZE PDB 1I18 http://www.ebi.ac.uk/pdbe-srv/view/entry/1I18 PDB 1I8D http://www.ebi.ac.uk/pdbe-srv/view/entry/1I8D PDB 1PKV http://www.ebi.ac.uk/pdbe-srv/view/entry/1PKV PDBsum 1HZE http://www.ebi.ac.uk/pdbsum/1HZE PDBsum 1I18 http://www.ebi.ac.uk/pdbsum/1I18 PDBsum 1I8D http://www.ebi.ac.uk/pdbsum/1I8D PDBsum 1PKV http://www.ebi.ac.uk/pdbsum/1PKV PROSITE PS51177 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51177 PSORT swissprot:RISA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RISA_ECOLI PSORT-B swissprot:RISA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RISA_ECOLI PSORT2 swissprot:RISA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RISA_ECOLI Pfam PF00677 http://pfam.xfam.org/family/PF00677 Phobius swissprot:RISA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RISA_ECOLI PhylomeDB P0AFU8 http://phylomedb.org/?seqid=P0AFU8 ProteinModelPortal P0AFU8 http://www.proteinmodelportal.org/query/uniprot/P0AFU8 PubMed 11377200 http://www.ncbi.nlm.nih.gov/pubmed/11377200 PubMed 11399071 http://www.ncbi.nlm.nih.gov/pubmed/11399071 PubMed 12927541 http://www.ncbi.nlm.nih.gov/pubmed/12927541 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9022701 http://www.ncbi.nlm.nih.gov/pubmed/9022701 PubMed 9023191 http://www.ncbi.nlm.nih.gov/pubmed/9023191 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416179 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416179 RefSeq WP_000493947 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000493947 SMR P0AFU8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFU8 STRING 511145.b1662 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1662&targetmode=cogs STRING COG0307 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0307&targetmode=cogs SUPFAM SSF63380 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63380 SWISS-2DPAGE P0AFU8 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AFU8 TIGRFAMs TIGR00187 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00187 UniProtKB RISA_ECOLI http://www.uniprot.org/uniprot/RISA_ECOLI UniProtKB-AC P0AFU8 http://www.uniprot.org/uniprot/P0AFU8 charge swissprot:RISA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RISA_ECOLI eggNOG COG0307 http://eggnogapi.embl.de/nog_data/html/tree/COG0307 eggNOG ENOG4108R6K http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108R6K epestfind swissprot:RISA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RISA_ECOLI garnier swissprot:RISA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RISA_ECOLI helixturnhelix swissprot:RISA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RISA_ECOLI hmoment swissprot:RISA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RISA_ECOLI iep swissprot:RISA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RISA_ECOLI inforesidue swissprot:RISA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RISA_ECOLI octanol swissprot:RISA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RISA_ECOLI pepcoil swissprot:RISA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RISA_ECOLI pepdigest swissprot:RISA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RISA_ECOLI pepinfo swissprot:RISA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RISA_ECOLI pepnet swissprot:RISA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RISA_ECOLI pepstats swissprot:RISA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RISA_ECOLI pepwheel swissprot:RISA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RISA_ECOLI pepwindow swissprot:RISA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RISA_ECOLI sigcleave swissprot:RISA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RISA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262897 14 # CATALYTIC ACTIVITY NARZ_ECOLI Nitrite + acceptor = nitrate + reduced acceptor. # COFACTOR NARZ_ECOLI Name=Mo-bis(molybdopterin guanine dinucleotide); Xref=ChEBI CHEBI 60539; Evidence={ECO 0000250}; Note=Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit. {ECO 0000250}; # COFACTOR NARZ_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000250}; Note=Binds 1 [4Fe-4S] cluster per subunit. {ECO 0000250}; # EcoGene EG10648 narZ # FUNCTION NARZ_ECOLI The alpha chain is the actual site of nitrate reduction. # FUNCTION NARZ_ECOLI This is a second nitrate reductase enzyme which can substitute for the NRA enzyme and allows E.coli to use nitrate as an electron acceptor during anaerobic growth. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0009325 nitrate reductase complex; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0008940 nitrate reductase activity; IDA:EcoCyc. # GO_function GO:0009055 electron carrier activity; IEA:InterPro. # GO_function GO:0030151 molybdenum ion binding; IEA:InterPro. # GO_function GO:0043546 molybdopterin cofactor binding; ISM:EcoCyc. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0009061 anaerobic respiration; IDA:EcoCyc. # GO_process GO:0019645 anaerobic electron transport chain; IDA:EcoCyc. # GO_process GO:0042128 nitrate assimilation; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0071941 nitrogen cycle metabolic process # INTERACTION NARZ_ECOLI P11349 narH; NbExp=4; IntAct=EBI-547262, EBI-555067; P0AF26 narJ; NbExp=3; IntAct=EBI-547262, EBI-555043; P19317 narW; NbExp=3; IntAct=EBI-547262, EBI-555088; # IntAct P19319 29 # InterPro IPR006468 NarG # InterPro IPR006655 Mopterin_OxRdtase_prok_CS # InterPro IPR006656 Mopterin_OxRdtase # InterPro IPR006657 MoPterin_dinucl-bd_dom # InterPro IPR006963 Mopterin_OxRdtase_4Fe-4S_dom # InterPro IPR009010 Asp_de-COase-like_dom # InterPro IPR027467 MopterinOxRdtase_cofactor_BS # InterPro IPR028189 Nitr_red_alph_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00910 Nitrogen metabolism # Organism NARZ_ECOLI Escherichia coli (strain K12) # PATRIC 32118228 VBIEscCol129921_1534 # PIR G64899 G64899 # PROSITE PS00490 MOLYBDOPTERIN_PROK_2 # PROSITE PS00551 MOLYBDOPTERIN_PROK_1 # PROSITE PS00932 MOLYBDOPTERIN_PROK_3 # PROSITE PS51669 4FE4S_MOW_BIS_MGD # Pfam PF00384 Molybdopterin # Pfam PF01568 Molydop_binding # Pfam PF14710 Nitr_red_alph_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NARZ_ECOLI Respiratory nitrate reductase 2 alpha chain # RefSeq NP_415985 NC_000913.3 # RefSeq WP_000040458 NZ_LN832404.1 # SIMILARITY Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. {ECO 0000305}. # SIMILARITY Contains 1 4Fe-4S Mo/W bis-MGD-type domain. {ECO:0000255|PROSITE-ProRule PRU01004}. # SMART SM00926 Molybdop_Fe4S4 # SUBCELLULAR LOCATION NARZ_ECOLI Cell membrane; Peripheral membrane protein. # SUBUNIT NARZ_ECOLI Tetramer composed of an alpha, a beta and 2 gamma chains. Alpha and beta are catalytic chains; gamma chain is involved in binding the enzyme complex to the cytoplasmic membrane. # SUPFAM SSF50692 SSF50692 # TCDB 5.A.3.1 the prokaryotic molybdopterin-containing oxidoreductase (pmo) family # TIGRFAMs TIGR01580 narG # eggNOG COG5013 LUCA # eggNOG ENOG4105CRU Bacteria BLAST swissprot:NARZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NARZ_ECOLI BioCyc ECOL316407:JW1463-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1463-MONOMER BioCyc EcoCyc:NARZ-MONOMER http://biocyc.org/getid?id=EcoCyc:NARZ-MONOMER BioCyc MetaCyc:NARZ-MONOMER http://biocyc.org/getid?id=MetaCyc:NARZ-MONOMER COG COG0243 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0243 DIP DIP-10324N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10324N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.7.99.4 http://www.genome.jp/dbget-bin/www_bget?EC:1.7.99.4 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X17110 http://www.ebi.ac.uk/ena/data/view/X17110 EMBL X94992 http://www.ebi.ac.uk/ena/data/view/X94992 ENZYME 1.7.99.4 http://enzyme.expasy.org/EC/1.7.99.4 EchoBASE EB0642 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0642 EcoGene EG10648 http://www.ecogene.org/geneInfo.php?eg_id=EG10648 EnsemblBacteria AAC74550 http://www.ensemblgenomes.org/id/AAC74550 EnsemblBacteria AAC74550 http://www.ensemblgenomes.org/id/AAC74550 EnsemblBacteria BAA15105 http://www.ensemblgenomes.org/id/BAA15105 EnsemblBacteria BAA15105 http://www.ensemblgenomes.org/id/BAA15105 EnsemblBacteria BAA15105 http://www.ensemblgenomes.org/id/BAA15105 EnsemblBacteria b1468 http://www.ensemblgenomes.org/id/b1468 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0009325 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009325 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0008940 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008940 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0030151 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030151 GO_function GO:0043546 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043546 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0009061 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009061 GO_process GO:0019645 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019645 GO_process GO:0042128 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042128 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0071941 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071941 GeneID 945999 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945999 HOGENOM HOG000237341 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000237341&db=HOGENOM6 InParanoid P19319 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P19319 IntAct P19319 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P19319* IntEnz 1.7.99.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.7.99.4 InterPro IPR006468 http://www.ebi.ac.uk/interpro/entry/IPR006468 InterPro IPR006655 http://www.ebi.ac.uk/interpro/entry/IPR006655 InterPro IPR006656 http://www.ebi.ac.uk/interpro/entry/IPR006656 InterPro IPR006657 http://www.ebi.ac.uk/interpro/entry/IPR006657 InterPro IPR006963 http://www.ebi.ac.uk/interpro/entry/IPR006963 InterPro IPR009010 http://www.ebi.ac.uk/interpro/entry/IPR009010 InterPro IPR027467 http://www.ebi.ac.uk/interpro/entry/IPR027467 InterPro IPR028189 http://www.ebi.ac.uk/interpro/entry/IPR028189 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1463 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1463 KEGG_Gene eco:b1468 http://www.genome.jp/dbget-bin/www_bget?eco:b1468 KEGG_Orthology KO:K08345 http://www.genome.jp/dbget-bin/www_bget?KO:K08345 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Reaction rn:R00798 http://www.genome.jp/dbget-bin/www_bget?rn:R00798 KEGG_Reaction rn:R01106 http://www.genome.jp/dbget-bin/www_bget?rn:R01106 MINT MINT-1261362 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1261362 OMA VKQEPVL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VKQEPVL PROSITE PS00490 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00490 PROSITE PS00551 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00551 PROSITE PS00932 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00932 PROSITE PS51669 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51669 PSORT swissprot:NARZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NARZ_ECOLI PSORT-B swissprot:NARZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NARZ_ECOLI PSORT2 swissprot:NARZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NARZ_ECOLI Pfam PF00384 http://pfam.xfam.org/family/PF00384 Pfam PF01568 http://pfam.xfam.org/family/PF01568 Pfam PF14710 http://pfam.xfam.org/family/PF14710 Phobius swissprot:NARZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NARZ_ECOLI PhylomeDB P19319 http://phylomedb.org/?seqid=P19319 ProteinModelPortal P19319 http://www.proteinmodelportal.org/query/uniprot/P19319 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2233673 http://www.ncbi.nlm.nih.gov/pubmed/2233673 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415985 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415985 RefSeq WP_000040458 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000040458 SMART SM00926 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00926 SMR P19319 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P19319 STRING 511145.b1468 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1468&targetmode=cogs STRING COG0243 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0243&targetmode=cogs SUPFAM SSF50692 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50692 TCDB 5.A.3.1 http://www.tcdb.org/search/result.php?tc=5.A.3.1 TIGRFAMs TIGR01580 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01580 UniProtKB NARZ_ECOLI http://www.uniprot.org/uniprot/NARZ_ECOLI UniProtKB-AC P19319 http://www.uniprot.org/uniprot/P19319 charge swissprot:NARZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NARZ_ECOLI eggNOG COG5013 http://eggnogapi.embl.de/nog_data/html/tree/COG5013 eggNOG ENOG4105CRU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CRU epestfind swissprot:NARZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NARZ_ECOLI garnier swissprot:NARZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NARZ_ECOLI helixturnhelix swissprot:NARZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NARZ_ECOLI hmoment swissprot:NARZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NARZ_ECOLI iep swissprot:NARZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NARZ_ECOLI inforesidue swissprot:NARZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NARZ_ECOLI octanol swissprot:NARZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NARZ_ECOLI pepcoil swissprot:NARZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NARZ_ECOLI pepdigest swissprot:NARZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NARZ_ECOLI pepinfo swissprot:NARZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NARZ_ECOLI pepnet swissprot:NARZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NARZ_ECOLI pepstats swissprot:NARZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NARZ_ECOLI pepwheel swissprot:NARZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NARZ_ECOLI pepwindow swissprot:NARZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NARZ_ECOLI sigcleave swissprot:NARZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NARZ_ECOLI ## Database ID URL or Descriptions # BioGrid 4261526 9 # EcoGene EG11256 iraP # FUNCTION IRAP_ECOLI Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS especially during phosphate starvation, but also in stationary phase and during nitrogen starvation. Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway. {ECO 0000269|PubMed 16600914, ECO 0000269|PubMed 18383615}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0043856 anti-sigma factor antagonist activity; IDA:EcoCyc. # GO_process GO:0016036 cellular response to phosphate starvation; IMP:EcoCyc. # GO_process GO:0042177 negative regulation of protein catabolic process; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0000988 transcription factor activity, protein binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # HAMAP MF_01198 Anti_adapt_IraP # INDUCTION IRAP_ECOLI By phosphate and nitrogen starvation, and in stationary phase, via the alarmone ppGpp. {ECO 0000269|PubMed 16600914, ECO 0000269|PubMed 17640895}. # IntAct P0AAN9 8 # InterPro IPR019732 SigmaS_Anti-adapt_IraP # Organism IRAP_ECOLI Escherichia coli (strain K12) # PATRIC 32115905 VBIEscCol129921_0394 # PIR F64766 F64766 # Pfam PF10796 Anti-adapt_IraP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName IRAP_ECOLI Anti-adapter protein IraP # RefSeq NP_414916 NC_000913.3 # RefSeq WP_000792970 NZ_LN832404.1 # SIMILARITY Belongs to the IraP family. {ECO 0000305}. # SUBCELLULAR LOCATION IRAP_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Interacts with RssB. {ECO:0000269|PubMed 16600914}. # eggNOG ENOG4105RZQ Bacteria # eggNOG ENOG4111YMR LUCA BLAST swissprot:IRAP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:IRAP_ECOLI BioCyc ECOL316407:JW0373-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0373-MONOMER BioCyc EcoCyc:EG11256-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11256-MONOMER DIP DIP-48131N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48131N DOI 10.1016/0378-1119(86)90050-8 http://dx.doi.org/10.1016/0378-1119(86)90050-8 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0705561104 http://dx.doi.org/10.1073/pnas.0705561104 DOI 10.1093/nar/9.21.5671 http://dx.doi.org/10.1093/nar/9.21.5671 DOI 10.1101/gad.1400306 http://dx.doi.org/10.1101/gad.1400306 DOI 10.1111/j.1365-2958.2008.06146.x http://dx.doi.org/10.1111/j.1365-2958.2008.06146.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01659 http://www.ebi.ac.uk/ena/data/view/J01659 EMBL M13345 http://www.ebi.ac.uk/ena/data/view/M13345 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB1236 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1236 EcoGene EG11256 http://www.ecogene.org/geneInfo.php?eg_id=EG11256 EnsemblBacteria AAC73485 http://www.ensemblgenomes.org/id/AAC73485 EnsemblBacteria AAC73485 http://www.ensemblgenomes.org/id/AAC73485 EnsemblBacteria BAE76163 http://www.ensemblgenomes.org/id/BAE76163 EnsemblBacteria BAE76163 http://www.ensemblgenomes.org/id/BAE76163 EnsemblBacteria BAE76163 http://www.ensemblgenomes.org/id/BAE76163 EnsemblBacteria b0382 http://www.ensemblgenomes.org/id/b0382 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0043856 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043856 GO_process GO:0016036 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016036 GO_process GO:0042177 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042177 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0000988 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000988 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 947709 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947709 HAMAP MF_01198 http://hamap.expasy.org/unirule/MF_01198 HOGENOM HOG000059299 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000059299&db=HOGENOM6 IntAct P0AAN9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAN9* InterPro IPR019732 http://www.ebi.ac.uk/interpro/entry/IPR019732 KEGG_Gene ecj:JW0373 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0373 KEGG_Gene eco:b0382 http://www.genome.jp/dbget-bin/www_bget?eco:b0382 OMA RNMAQSE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RNMAQSE PSORT swissprot:IRAP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:IRAP_ECOLI PSORT-B swissprot:IRAP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:IRAP_ECOLI PSORT2 swissprot:IRAP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:IRAP_ECOLI Pfam PF10796 http://pfam.xfam.org/family/PF10796 Phobius swissprot:IRAP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:IRAP_ECOLI ProteinModelPortal P0AAN9 http://www.proteinmodelportal.org/query/uniprot/P0AAN9 PubMed 16600914 http://www.ncbi.nlm.nih.gov/pubmed/16600914 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17640895 http://www.ncbi.nlm.nih.gov/pubmed/17640895 PubMed 18383615 http://www.ncbi.nlm.nih.gov/pubmed/18383615 PubMed 3533724 http://www.ncbi.nlm.nih.gov/pubmed/3533724 PubMed 6273802 http://www.ncbi.nlm.nih.gov/pubmed/6273802 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414916 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414916 RefSeq WP_000792970 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000792970 SMR P0AAN9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAN9 STRING 511145.b0382 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0382&targetmode=cogs UniProtKB IRAP_ECOLI http://www.uniprot.org/uniprot/IRAP_ECOLI UniProtKB-AC P0AAN9 http://www.uniprot.org/uniprot/P0AAN9 charge swissprot:IRAP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:IRAP_ECOLI eggNOG ENOG4105RZQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105RZQ eggNOG ENOG4111YMR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111YMR epestfind swissprot:IRAP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:IRAP_ECOLI garnier swissprot:IRAP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:IRAP_ECOLI helixturnhelix swissprot:IRAP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:IRAP_ECOLI hmoment swissprot:IRAP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:IRAP_ECOLI iep swissprot:IRAP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:IRAP_ECOLI inforesidue swissprot:IRAP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:IRAP_ECOLI octanol swissprot:IRAP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:IRAP_ECOLI pepcoil swissprot:IRAP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:IRAP_ECOLI pepdigest swissprot:IRAP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:IRAP_ECOLI pepinfo swissprot:IRAP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:IRAP_ECOLI pepnet swissprot:IRAP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:IRAP_ECOLI pepstats swissprot:IRAP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:IRAP_ECOLI pepwheel swissprot:IRAP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:IRAP_ECOLI pepwindow swissprot:IRAP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:IRAP_ECOLI sigcleave swissprot:IRAP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:IRAP_ECOLI ## Database ID URL or Descriptions # AltName Beta-N-acetylhexosaminidase {ECO:0000255|HAMAP-Rule MF_00364} # AltName N-acetyl-beta-glucosaminidase {ECO:0000255|HAMAP-Rule MF_00364} # BIOPHYSICOCHEMICAL PROPERTIES pH dependence Optimum pH is 7.7.; # BioGrid 4259534 30 # CATALYTIC ACTIVITY Hydrolysis of terminal non-reducing N-acetyl- D-hexosamine residues in N-acetyl-beta-D-hexosaminides. {ECO:0000255|HAMAP-Rule MF_00364}. # CAZy GH3 Glycoside Hydrolase Family 3 # ENZYME REGULATION NAGZ_ECOLI Slightly inhibited by GlcNAc and N- acetylmuramic acid and strongly inhibited by N- acetylglucosaminolactone. # EcoGene EG13433 nagZ # FUNCTION NAGZ_ECOLI Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004563 beta-N-acetylhexosaminidase activity; IDA:EcoCyc. # GO_process GO:0005975 carbohydrate metabolic process; IEA:InterPro. # GO_process GO:0007049 cell cycle; IEA:UniProtKB-KW. # GO_process GO:0008360 regulation of cell shape; IEA:UniProtKB-KW. # GO_process GO:0009252 peptidoglycan biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0009254 peptidoglycan turnover; IMP:EcoliWiki. # GO_process GO:0051301 cell division; IEA:UniProtKB-KW. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0007049 cell cycle # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0051301 cell division # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 3.20.20.300 -; 1. # HAMAP MF_00364 NagZ # IntAct P75949 8 # InterPro IPR001764 Glyco_hydro_3_N # InterPro IPR017853 Glycoside_hydrolase_SF # InterPro IPR019800 Glyco_hydro_3_AS # InterPro IPR022956 Beta_hexosaminidase_bac # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00520 Amino sugar and nucleotide sugar metabolism # Organism NAGZ_ECOLI Escherichia coli (strain K12) # PATHWAY Cell wall biogenesis; peptidoglycan recycling. {ECO:0000255|HAMAP-Rule MF_00364}. # PATRIC 32117457 VBIEscCol129921_1151 # PIR H64854 H64854 # PROSITE PS00775 GLYCOSYL_HYDROL_F3 # Pfam PF00933 Glyco_hydro_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Beta-hexosaminidase {ECO:0000255|HAMAP-Rule MF_00364} # RefSeq NP_415625 NC_000913.3 # RefSeq WP_000529320 NZ_LN832404.1 # SIMILARITY Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. {ECO:0000255|HAMAP-Rule MF_00364}. # SUBCELLULAR LOCATION NAGZ_ECOLI Cytoplasm. # SUBUNIT Monomer. {ECO 0000305}. # SUPFAM SSF51445 SSF51445 # eggNOG COG1472 LUCA # eggNOG ENOG4107QPA Bacteria BLAST swissprot:NAGZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NAGZ_ECOLI BioCyc ECOL316407:JW1093-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1093-MONOMER BioCyc EcoCyc:G6567-MONOMER http://biocyc.org/getid?id=EcoCyc:G6567-MONOMER BioCyc MetaCyc:G6567-MONOMER http://biocyc.org/getid?id=MetaCyc:G6567-MONOMER COG COG1472 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1472 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.17.4836-4840.2000 http://dx.doi.org/10.1128/JB.182.17.4836-4840.2000 EC_number EC:3.2.1.52 {ECO:0000255|HAMAP-Rule:MF_00364} http://www.genome.jp/dbget-bin/www_bget?EC:3.2.1.52 {ECO:0000255|HAMAP-Rule:MF_00364} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.2.1.52 {ECO:0000255|HAMAP-Rule:MF_00364} http://enzyme.expasy.org/EC/3.2.1.52 {ECO:0000255|HAMAP-Rule:MF_00364} EchoBASE EB3207 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3207 EcoGene EG13433 http://www.ecogene.org/geneInfo.php?eg_id=EG13433 EnsemblBacteria AAC74191 http://www.ensemblgenomes.org/id/AAC74191 EnsemblBacteria AAC74191 http://www.ensemblgenomes.org/id/AAC74191 EnsemblBacteria BAA35914 http://www.ensemblgenomes.org/id/BAA35914 EnsemblBacteria BAA35914 http://www.ensemblgenomes.org/id/BAA35914 EnsemblBacteria BAA35914 http://www.ensemblgenomes.org/id/BAA35914 EnsemblBacteria b1107 http://www.ensemblgenomes.org/id/b1107 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004563 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004563 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GO_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0009252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009252 GO_process GO:0009254 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009254 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 3.20.20.300 http://www.cathdb.info/version/latest/superfamily/3.20.20.300 GeneID 945671 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945671 HAMAP MF_00364 http://hamap.expasy.org/unirule/MF_00364 HOGENOM HOG000248526 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000248526&db=HOGENOM6 InParanoid P75949 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75949 IntAct P75949 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75949* IntEnz 3.2.1.52 {ECO:0000255|HAMAP-Rule:MF_00364} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.2.1.52 {ECO:0000255|HAMAP-Rule:MF_00364} InterPro IPR001764 http://www.ebi.ac.uk/interpro/entry/IPR001764 InterPro IPR017853 http://www.ebi.ac.uk/interpro/entry/IPR017853 InterPro IPR019800 http://www.ebi.ac.uk/interpro/entry/IPR019800 InterPro IPR022956 http://www.ebi.ac.uk/interpro/entry/IPR022956 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1093 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1093 KEGG_Gene eco:b1107 http://www.genome.jp/dbget-bin/www_bget?eco:b1107 KEGG_Orthology KO:K01207 http://www.genome.jp/dbget-bin/www_bget?KO:K01207 KEGG_Pathway ko00520 http://www.genome.jp/kegg-bin/show_pathway?ko00520 KEGG_Reaction rn:R00022 http://www.genome.jp/dbget-bin/www_bget?rn:R00022 KEGG_Reaction rn:R05963 http://www.genome.jp/dbget-bin/www_bget?rn:R05963 KEGG_Reaction rn:R06004 http://www.genome.jp/dbget-bin/www_bget?rn:R06004 KEGG_Reaction rn:R07809 http://www.genome.jp/dbget-bin/www_bget?rn:R07809 KEGG_Reaction rn:R07810 http://www.genome.jp/dbget-bin/www_bget?rn:R07810 OMA DMVLICN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DMVLICN PROSITE PS00775 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00775 PSORT swissprot:NAGZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NAGZ_ECOLI PSORT-B swissprot:NAGZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NAGZ_ECOLI PSORT2 swissprot:NAGZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NAGZ_ECOLI Pfam PF00933 http://pfam.xfam.org/family/PF00933 Phobius swissprot:NAGZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NAGZ_ECOLI PhylomeDB P75949 http://phylomedb.org/?seqid=P75949 ProteinModelPortal P75949 http://www.proteinmodelportal.org/query/uniprot/P75949 PubMed 10940025 http://www.ncbi.nlm.nih.gov/pubmed/10940025 PubMed 1377 http://www.ncbi.nlm.nih.gov/pubmed/1377 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415625 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415625 RefSeq WP_000529320 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000529320 SMR P75949 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75949 STRING 511145.b1107 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1107&targetmode=cogs STRING COG1472 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1472&targetmode=cogs SUPFAM SSF51445 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51445 UniProtKB NAGZ_ECOLI http://www.uniprot.org/uniprot/NAGZ_ECOLI UniProtKB-AC P75949 http://www.uniprot.org/uniprot/P75949 charge swissprot:NAGZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NAGZ_ECOLI eggNOG COG1472 http://eggnogapi.embl.de/nog_data/html/tree/COG1472 eggNOG ENOG4107QPA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QPA epestfind swissprot:NAGZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NAGZ_ECOLI garnier swissprot:NAGZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NAGZ_ECOLI helixturnhelix swissprot:NAGZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NAGZ_ECOLI hmoment swissprot:NAGZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NAGZ_ECOLI iep swissprot:NAGZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NAGZ_ECOLI inforesidue swissprot:NAGZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NAGZ_ECOLI octanol swissprot:NAGZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NAGZ_ECOLI pepcoil swissprot:NAGZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NAGZ_ECOLI pepdigest swissprot:NAGZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NAGZ_ECOLI pepinfo swissprot:NAGZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NAGZ_ECOLI pepnet swissprot:NAGZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NAGZ_ECOLI pepstats swissprot:NAGZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NAGZ_ECOLI pepwheel swissprot:NAGZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NAGZ_ECOLI pepwindow swissprot:NAGZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NAGZ_ECOLI sigcleave swissprot:NAGZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NAGZ_ECOLI ## Database ID URL or Descriptions # BioGrid 4259336 124 # EcoGene EG14230 yqiI # FUNCTION YQII_ECOLI May be involved in a fimbrial system chaperoned by YqiH and exported by YqiG. # GO_component GO:0009289 pilus; IEA:InterPro. # GO_process GO:0007155 cell adhesion; IEA:InterPro. # GO_process GO:0051595 response to methylglyoxal; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0007155 cell adhesion # GOslim_process GO:0008150 biological_process # Gene3D 2.60.40.1090 -; 1. # InterPro IPR000259 Adhesion_dom_fimbrial # InterPro IPR008966 Adhesion_dom # Organism YQII_ECOLI Escherichia coli (strain K12) # PATRIC 32121508 VBIEscCol129921_3141 # PIR F65092 F65092 # Pfam PF00419 Fimbrial # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQII_ECOLI Uncharacterized protein YqiI # RefSeq NP_417520 NC_000913.3 # RefSeq WP_001269802 NZ_LN832404.1 # SIMILARITY To E.coli YbgO. {ECO 0000305}. # SUPFAM SSF49401 SSF49401 # eggNOG ENOG4108MY7 Bacteria # eggNOG ENOG4110VJC LUCA BLAST swissprot:YQII_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQII_ECOLI BioCyc ECOL316407:JW5509-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5509-MONOMER BioCyc EcoCyc:G7587-MONOMER http://biocyc.org/getid?id=EcoCyc:G7587-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3981 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3981 EcoGene EG14230 http://www.ecogene.org/geneInfo.php?eg_id=EG14230 EnsemblBacteria AAC76084 http://www.ensemblgenomes.org/id/AAC76084 EnsemblBacteria AAC76084 http://www.ensemblgenomes.org/id/AAC76084 EnsemblBacteria BAE77101 http://www.ensemblgenomes.org/id/BAE77101 EnsemblBacteria BAE77101 http://www.ensemblgenomes.org/id/BAE77101 EnsemblBacteria BAE77101 http://www.ensemblgenomes.org/id/BAE77101 EnsemblBacteria b3048 http://www.ensemblgenomes.org/id/b3048 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009289 GO_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GO_process GO:0051595 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051595 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 2.60.40.1090 http://www.cathdb.info/version/latest/superfamily/2.60.40.1090 GeneID 947535 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947535 HOGENOM HOG000125082 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125082&db=HOGENOM6 InParanoid P76656 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76656 InterPro IPR000259 http://www.ebi.ac.uk/interpro/entry/IPR000259 InterPro IPR008966 http://www.ebi.ac.uk/interpro/entry/IPR008966 KEGG_Gene ecj:JW5509 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5509 KEGG_Gene eco:b3048 http://www.genome.jp/dbget-bin/www_bget?eco:b3048 OMA CIDVKGA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CIDVKGA PSORT swissprot:YQII_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQII_ECOLI PSORT-B swissprot:YQII_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQII_ECOLI PSORT2 swissprot:YQII_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQII_ECOLI Pfam PF00419 http://pfam.xfam.org/family/PF00419 Phobius swissprot:YQII_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQII_ECOLI ProteinModelPortal P76656 http://www.proteinmodelportal.org/query/uniprot/P76656 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417520 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417520 RefSeq WP_001269802 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001269802 STRING 511145.b3048 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3048&targetmode=cogs SUPFAM SSF49401 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49401 UniProtKB YQII_ECOLI http://www.uniprot.org/uniprot/YQII_ECOLI UniProtKB-AC P76656 http://www.uniprot.org/uniprot/P76656 charge swissprot:YQII_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQII_ECOLI eggNOG ENOG4108MY7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MY7 eggNOG ENOG4110VJC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4110VJC epestfind swissprot:YQII_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQII_ECOLI garnier swissprot:YQII_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQII_ECOLI helixturnhelix swissprot:YQII_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQII_ECOLI hmoment swissprot:YQII_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQII_ECOLI iep swissprot:YQII_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQII_ECOLI inforesidue swissprot:YQII_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQII_ECOLI octanol swissprot:YQII_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQII_ECOLI pepcoil swissprot:YQII_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQII_ECOLI pepdigest swissprot:YQII_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQII_ECOLI pepinfo swissprot:YQII_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQII_ECOLI pepnet swissprot:YQII_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQII_ECOLI pepstats swissprot:YQII_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQII_ECOLI pepwheel swissprot:YQII_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQII_ECOLI pepwindow swissprot:YQII_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQII_ECOLI sigcleave swissprot:YQII_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQII_ECOLI ## Database ID URL or Descriptions # EcoGene EG14449 ymgI # Organism YMGI_ECOLI Escherichia coli (strain K12) # Proteomes UP000000625 Chromosome # RecName YMGI_ECOLI Uncharacterized protein YmgI # RefSeq WP_000122462 NZ_LN832404.1 # RefSeq YP_001165314 NC_000913.3 BLAST swissprot:YMGI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YMGI_ECOLI BioCyc EcoCyc:MONOMER0-2818 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2818 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14449 http://www.ecogene.org/geneInfo.php?eg_id=EG14449 EnsemblBacteria ABP93440 http://www.ensemblgenomes.org/id/ABP93440 EnsemblBacteria ABP93440 http://www.ensemblgenomes.org/id/ABP93440 EnsemblBacteria b4593 http://www.ensemblgenomes.org/id/b4593 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 5061515 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5061515 HOGENOM HOG000009432 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009432&db=HOGENOM6 KEGG_Gene eco:b4593 http://www.genome.jp/dbget-bin/www_bget?eco:b4593 PSORT swissprot:YMGI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YMGI_ECOLI PSORT-B swissprot:YMGI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YMGI_ECOLI PSORT2 swissprot:YMGI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YMGI_ECOLI Phobius swissprot:YMGI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YMGI_ECOLI ProteinModelPortal A5A611 http://www.proteinmodelportal.org/query/uniprot/A5A611 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000122462 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000122462 RefSeq YP_001165314 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001165314 STRING 511145.b4593 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4593&targetmode=cogs UniProtKB YMGI_ECOLI http://www.uniprot.org/uniprot/YMGI_ECOLI UniProtKB-AC A5A611 http://www.uniprot.org/uniprot/A5A611 charge swissprot:YMGI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YMGI_ECOLI epestfind swissprot:YMGI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YMGI_ECOLI garnier swissprot:YMGI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YMGI_ECOLI helixturnhelix swissprot:YMGI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YMGI_ECOLI hmoment swissprot:YMGI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YMGI_ECOLI iep swissprot:YMGI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YMGI_ECOLI inforesidue swissprot:YMGI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YMGI_ECOLI octanol swissprot:YMGI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YMGI_ECOLI pepcoil swissprot:YMGI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YMGI_ECOLI pepdigest swissprot:YMGI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YMGI_ECOLI pepinfo swissprot:YMGI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YMGI_ECOLI pepnet swissprot:YMGI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YMGI_ECOLI pepstats swissprot:YMGI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YMGI_ECOLI pepwheel swissprot:YMGI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YMGI_ECOLI pepwindow swissprot:YMGI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YMGI_ECOLI sigcleave swissprot:YMGI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YMGI_ECOLI ## Database ID URL or Descriptions # BioGrid 4260697 7 # EcoGene EG10547 lrp # FUNCTION LRP_ECOLI Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0016597 amino acid binding; IBA:GO_Central. # GO_function GO:0043565 sequence-specific DNA binding; IDA:EcoliWiki. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IMP:EcoliWiki. # GO_process GO:0006524 alanine catabolic process; IBA:GO_Central. # GO_process GO:0009098 leucine biosynthetic process; IMP:EcoCyc. # GO_process GO:0043201 response to leucine; IMP:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # Gene3D 3.30.70.920 -; 1. # INTERACTION LRP_ECOLI Self; NbExp=2; IntAct=EBI-1113316, EBI-1113316; P0AFW4 rnk; NbExp=4; IntAct=EBI-1113316, EBI-553769; # IntAct P0ACJ0 12 # InterPro IPR000485 AsnC-type_HTH_dom # InterPro IPR011008 Dimeric_a/b-barrel # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR019885 Tscrpt_reg_HTH_AsnC-type_CS # InterPro IPR019887 Tscrpt_reg_AsnC/Lrp_C # InterPro IPR019888 Tscrpt_reg_AsnC-typ # KEGG_Brite ko03000 Transcription factors # KEGG_Brite ko03036 Chromosome # Organism LRP_ECOLI Escherichia coli (strain K12) # PATRIC 32116989 VBIEscCol129921_0919 # PDB 2GQQ X-ray; 3.20 A; A/B/C/D=2-164 # PDB 2L4A NMR; -; A=1-66 # PIR JH0412 RGECLR # PRINTS PR00033 HTHASNC # PROSITE PS00519 HTH_ASNC_1 # PROSITE PS50956 HTH_ASNC_2 # Pfam PF01037 AsnC_trans_reg # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LRP_ECOLI Leucine-responsive regulatory protein # RefSeq NP_415409 NC_000913.3 # RefSeq WP_000228473 NZ_LN832404.1 # SIMILARITY Contains 1 HTH asnC-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00319}. # SMART SM00344 HTH_ASNC # SUBUNIT LRP_ECOLI Homodimer. # SUPFAM SSF46785 SSF46785 # SUPFAM SSF54909 SSF54909 # eggNOG COG1522 LUCA BLAST swissprot:LRP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LRP_ECOLI BioCyc ECOL316407:JW0872-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0872-MONOMER BioCyc EcoCyc:PD00353 http://biocyc.org/getid?id=EcoCyc:PD00353 COG COG1522 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1522 DIP DIP-35825N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35825N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0968-0004(93)90177-O http://dx.doi.org/10.1016/0968-0004(93)90177-O DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D11105 http://www.ebi.ac.uk/ena/data/view/D11105 EMBL M35869 http://www.ebi.ac.uk/ena/data/view/M35869 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0542 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0542 EcoGene EG10547 http://www.ecogene.org/geneInfo.php?eg_id=EG10547 EnsemblBacteria AAC73975 http://www.ensemblgenomes.org/id/AAC73975 EnsemblBacteria AAC73975 http://www.ensemblgenomes.org/id/AAC73975 EnsemblBacteria BAA35614 http://www.ensemblgenomes.org/id/BAA35614 EnsemblBacteria BAA35614 http://www.ensemblgenomes.org/id/BAA35614 EnsemblBacteria BAA35614 http://www.ensemblgenomes.org/id/BAA35614 EnsemblBacteria b0889 http://www.ensemblgenomes.org/id/b0889 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0016597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016597 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0006524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006524 GO_process GO:0009098 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009098 GO_process GO:0043201 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043201 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 3.30.70.920 http://www.cathdb.info/version/latest/superfamily/3.30.70.920 GeneID 949051 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949051 HOGENOM HOG000115327 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000115327&db=HOGENOM6 InParanoid P0ACJ0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACJ0 IntAct P0ACJ0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACJ0* InterPro IPR000485 http://www.ebi.ac.uk/interpro/entry/IPR000485 InterPro IPR011008 http://www.ebi.ac.uk/interpro/entry/IPR011008 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR019885 http://www.ebi.ac.uk/interpro/entry/IPR019885 InterPro IPR019887 http://www.ebi.ac.uk/interpro/entry/IPR019887 InterPro IPR019888 http://www.ebi.ac.uk/interpro/entry/IPR019888 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene ecj:JW0872 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0872 KEGG_Gene eco:b0889 http://www.genome.jp/dbget-bin/www_bget?eco:b0889 KEGG_Orthology KO:K03719 http://www.genome.jp/dbget-bin/www_bget?KO:K03719 OMA LVFVEIK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LVFVEIK PDB 2GQQ http://www.ebi.ac.uk/pdbe-srv/view/entry/2GQQ PDB 2L4A http://www.ebi.ac.uk/pdbe-srv/view/entry/2L4A PDBsum 2GQQ http://www.ebi.ac.uk/pdbsum/2GQQ PDBsum 2L4A http://www.ebi.ac.uk/pdbsum/2L4A PRINTS PR00033 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00033 PROSITE PS00519 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00519 PROSITE PS50956 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50956 PSORT swissprot:LRP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LRP_ECOLI PSORT-B swissprot:LRP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LRP_ECOLI PSORT2 swissprot:LRP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LRP_ECOLI Pfam PF01037 http://pfam.xfam.org/family/PF01037 Phobius swissprot:LRP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LRP_ECOLI PhylomeDB P0ACJ0 http://phylomedb.org/?seqid=P0ACJ0 ProteinModelPortal P0ACJ0 http://www.proteinmodelportal.org/query/uniprot/P0ACJ0 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1729203 http://www.ncbi.nlm.nih.gov/pubmed/1729203 PubMed 2040596 http://www.ncbi.nlm.nih.gov/pubmed/2040596 PubMed 2115869 http://www.ncbi.nlm.nih.gov/pubmed/2115869 PubMed 8212136 http://www.ncbi.nlm.nih.gov/pubmed/8212136 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_415409 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415409 RefSeq WP_000228473 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000228473 SMART SM00344 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00344 SMR P0ACJ0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACJ0 STRING 511145.b0889 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0889&targetmode=cogs STRING COG1522 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1522&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SUPFAM SSF54909 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54909 UniProtKB LRP_ECOLI http://www.uniprot.org/uniprot/LRP_ECOLI UniProtKB-AC P0ACJ0 http://www.uniprot.org/uniprot/P0ACJ0 charge swissprot:LRP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LRP_ECOLI eggNOG COG1522 http://eggnogapi.embl.de/nog_data/html/tree/COG1522 epestfind swissprot:LRP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LRP_ECOLI garnier swissprot:LRP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LRP_ECOLI helixturnhelix swissprot:LRP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LRP_ECOLI hmoment swissprot:LRP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LRP_ECOLI iep swissprot:LRP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LRP_ECOLI inforesidue swissprot:LRP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LRP_ECOLI octanol swissprot:LRP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LRP_ECOLI pepcoil swissprot:LRP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LRP_ECOLI pepdigest swissprot:LRP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LRP_ECOLI pepinfo swissprot:LRP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LRP_ECOLI pepnet swissprot:LRP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LRP_ECOLI pepstats swissprot:LRP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LRP_ECOLI pepwheel swissprot:LRP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LRP_ECOLI pepwindow swissprot:LRP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LRP_ECOLI sigcleave swissprot:LRP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LRP_ECOLI ## Database ID URL or Descriptions # AltName RIR4_ECOLI R2F protein # AltName RIR4_ECOLI Ribonucleotide reductase 2 # BRENDA 1.17.4 2026 # BioGrid 4262269 135 # CATALYTIC ACTIVITY 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H(2)O = ribonucleoside diphosphate + thioredoxin. {ECO:0000255|PROSITE-ProRule PRU10014}. # CDD cd01049 RNRR2 # COFACTOR RIR4_ECOLI Name=Fe cation; Xref=ChEBI CHEBI 24875; Evidence={ECO 0000250}; Note=Binds 2 iron ions per subunit. {ECO 0000250}; # EcoGene EG12381 nrdF # FUNCTION RIR4_ECOLI Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R2F contains the tyrosyl radical required for catalysis. # GO_component GO:0005737 cytoplasm; ISA:EcoliWiki. # GO_component GO:0005971 ribonucleoside-diphosphate reductase complex; IGI:EcoliWiki. # GO_function GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IEA:UniProtKB-EC. # GO_function GO:0005506 iron ion binding; ISA:EcoliWiki. # GO_function GO:0030145 manganese ion binding; IDA:EcoCyc. # GO_process GO:0006260 DNA replication; IEA:UniProtKB-UniPathway. # GO_process GO:0009263 deoxyribonucleotide biosynthetic process; IGI:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.620.20 -; 1. # INDUCTION Induced 2-fold by hydroxyurea. {ECO:0000269|PubMed 20005847}. # IntAct P37146 9 # InterPro IPR000358 RNR_small_fam # InterPro IPR009078 Ferritin-like_SF # InterPro IPR012348 RNR-rel # InterPro IPR026494 RNR_NrdF # InterPro IPR030475 RNR_small_AS # InterPro IPR033909 RNR_small # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00240 Pyrimidine metabolism # Organism RIR4_ECOLI Escherichia coli (strain K12) # PANTHER PTHR23409 PTHR23409 # PATHWAY RIR4_ECOLI Genetic information processing; DNA replication. # PATRIC 32120742 VBIEscCol129921_2768 # PDB 3N37 X-ray; 1.65 A; A=1-319 # PDB 3N38 X-ray; 1.90 A; A=1-319 # PDB 3N39 X-ray; 2.50 A; A/B=1-319 # PDB 3N3A X-ray; 1.99 A; A/B=1-319 # PDB 3N3B X-ray; 2.36 A; A/B=1-319 # PDB 4M1F X-ray; 2.00 A; A=1-319 # PIR E65047 E65047 # PIRSF PIRSF000355 NrdB # PROSITE PS00368 RIBORED_SMALL # Pfam PF00268 Ribonuc_red_sm # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RIR4_ECOLI Ribonucleoside-diphosphate reductase 2 subunit beta # RefSeq NP_417162 NC_000913.3 # RefSeq WP_000777969 NZ_LN832404.1 # SIMILARITY Belongs to the ribonucleoside diphosphate reductase small chain family. {ECO 0000305}. # SUBUNIT Tetramer of two alpha and two beta subunits. {ECO 0000250}. # SUPFAM SSF47240 SSF47240 # TIGRFAMs TIGR04171 RNR_1b_NrdF # eggNOG COG0208 LUCA # eggNOG ENOG4107R25 Bacteria BLAST swissprot:RIR4_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RIR4_ECOLI BioCyc ECOL316407:JW2651-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2651-MONOMER BioCyc EcoCyc:NRDF-MONOMER http://biocyc.org/getid?id=EcoCyc:NRDF-MONOMER BioCyc MetaCyc:NRDF-MONOMER http://biocyc.org/getid?id=MetaCyc:NRDF-MONOMER COG COG0208 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0208 DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.17.4.1 http://www.genome.jp/dbget-bin/www_bget?EC:1.17.4.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M24856 http://www.ebi.ac.uk/ena/data/view/M24856 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.17.4.1 http://enzyme.expasy.org/EC/1.17.4.1 EchoBASE EB2283 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2283 EcoGene EG12381 http://www.ecogene.org/geneInfo.php?eg_id=EG12381 EnsemblBacteria AAC75723 http://www.ensemblgenomes.org/id/AAC75723 EnsemblBacteria AAC75723 http://www.ensemblgenomes.org/id/AAC75723 EnsemblBacteria BAA16541 http://www.ensemblgenomes.org/id/BAA16541 EnsemblBacteria BAA16541 http://www.ensemblgenomes.org/id/BAA16541 EnsemblBacteria BAA16541 http://www.ensemblgenomes.org/id/BAA16541 EnsemblBacteria b2676 http://www.ensemblgenomes.org/id/b2676 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005971 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005971 GO_function GO:0004748 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004748 GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_process GO:0006260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260 GO_process GO:0009263 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009263 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.620.20 http://www.cathdb.info/version/latest/superfamily/1.10.620.20 GeneID 947149 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947149 HOGENOM HOG000246153 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000246153&db=HOGENOM6 InParanoid P37146 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37146 IntAct P37146 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37146* IntEnz 1.17.4.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.17.4.1 InterPro IPR000358 http://www.ebi.ac.uk/interpro/entry/IPR000358 InterPro IPR009078 http://www.ebi.ac.uk/interpro/entry/IPR009078 InterPro IPR012348 http://www.ebi.ac.uk/interpro/entry/IPR012348 InterPro IPR026494 http://www.ebi.ac.uk/interpro/entry/IPR026494 InterPro IPR030475 http://www.ebi.ac.uk/interpro/entry/IPR030475 InterPro IPR033909 http://www.ebi.ac.uk/interpro/entry/IPR033909 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW2651 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2651 KEGG_Gene eco:b2676 http://www.genome.jp/dbget-bin/www_bget?eco:b2676 KEGG_Orthology KO:K00526 http://www.genome.jp/dbget-bin/www_bget?KO:K00526 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Reaction rn:R02017 http://www.genome.jp/dbget-bin/www_bget?rn:R02017 KEGG_Reaction rn:R02018 http://www.genome.jp/dbget-bin/www_bget?rn:R02018 KEGG_Reaction rn:R02019 http://www.genome.jp/dbget-bin/www_bget?rn:R02019 KEGG_Reaction rn:R02024 http://www.genome.jp/dbget-bin/www_bget?rn:R02024 OMA MNLGQEP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MNLGQEP PANTHER PTHR23409 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23409 PDB 3N37 http://www.ebi.ac.uk/pdbe-srv/view/entry/3N37 PDB 3N38 http://www.ebi.ac.uk/pdbe-srv/view/entry/3N38 PDB 3N39 http://www.ebi.ac.uk/pdbe-srv/view/entry/3N39 PDB 3N3A http://www.ebi.ac.uk/pdbe-srv/view/entry/3N3A PDB 3N3B http://www.ebi.ac.uk/pdbe-srv/view/entry/3N3B PDB 4M1F http://www.ebi.ac.uk/pdbe-srv/view/entry/4M1F PDBsum 3N37 http://www.ebi.ac.uk/pdbsum/3N37 PDBsum 3N38 http://www.ebi.ac.uk/pdbsum/3N38 PDBsum 3N39 http://www.ebi.ac.uk/pdbsum/3N39 PDBsum 3N3A http://www.ebi.ac.uk/pdbsum/3N3A PDBsum 3N3B http://www.ebi.ac.uk/pdbsum/3N3B PDBsum 4M1F http://www.ebi.ac.uk/pdbsum/4M1F PROSITE PS00368 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00368 PSORT swissprot:RIR4_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RIR4_ECOLI PSORT-B swissprot:RIR4_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RIR4_ECOLI PSORT2 swissprot:RIR4_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RIR4_ECOLI Pfam PF00268 http://pfam.xfam.org/family/PF00268 Phobius swissprot:RIR4_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RIR4_ECOLI PhylomeDB P37146 http://phylomedb.org/?seqid=P37146 ProteinModelPortal P37146 http://www.proteinmodelportal.org/query/uniprot/P37146 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 2649479 http://www.ncbi.nlm.nih.gov/pubmed/2649479 PubMed 8195103 http://www.ncbi.nlm.nih.gov/pubmed/8195103 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417162 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417162 RefSeq WP_000777969 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000777969 SMR P37146 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37146 STRING 511145.b2676 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2676&targetmode=cogs STRING COG0208 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0208&targetmode=cogs SUPFAM SSF47240 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47240 TIGRFAMs TIGR04171 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR04171 UniProtKB RIR4_ECOLI http://www.uniprot.org/uniprot/RIR4_ECOLI UniProtKB-AC P37146 http://www.uniprot.org/uniprot/P37146 charge swissprot:RIR4_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RIR4_ECOLI eggNOG COG0208 http://eggnogapi.embl.de/nog_data/html/tree/COG0208 eggNOG ENOG4107R25 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107R25 epestfind swissprot:RIR4_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RIR4_ECOLI garnier swissprot:RIR4_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RIR4_ECOLI helixturnhelix swissprot:RIR4_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RIR4_ECOLI hmoment swissprot:RIR4_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RIR4_ECOLI iep swissprot:RIR4_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RIR4_ECOLI inforesidue swissprot:RIR4_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RIR4_ECOLI octanol swissprot:RIR4_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RIR4_ECOLI pepcoil swissprot:RIR4_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RIR4_ECOLI pepdigest swissprot:RIR4_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RIR4_ECOLI pepinfo swissprot:RIR4_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RIR4_ECOLI pepnet swissprot:RIR4_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RIR4_ECOLI pepstats swissprot:RIR4_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RIR4_ECOLI pepwheel swissprot:RIR4_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RIR4_ECOLI pepwindow swissprot:RIR4_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RIR4_ECOLI sigcleave swissprot:RIR4_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RIR4_ECOLI ## Database ID URL or Descriptions # BioGrid 4261044 426 # EcoGene EG11975 fliP # FUNCTION FLIP_ECOLI Plays a role in the flagellum-specific transport system. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0009425 bacterial-type flagellum basal body; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0009306 protein secretion; IEA:InterPro. # GO_process GO:0044781 bacterial-type flagellum organization; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # InterPro IPR005837 FliP # InterPro IPR005838 T3SS_IM_P # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko02040 Flagellar assembly # Organism FLIP_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30587:SF0 PTHR30587:SF0 # PATRIC 32119225 VBIEscCol129921_2027 # PIR B36869 B36869 # PRINTS PR00951 FLGBIOSNFLIP # PRINTS PR01302 TYPE3IMPPROT # PROSITE PS01060 FLIP_1 # PROSITE PS01061 FLIP_2 # Pfam PF00813 FliP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FLIP_ECOLI Flagellar biosynthetic protein FliP # RefSeq NP_416458 NC_000913.3 # RefSeq WP_001253441 NZ_LN832404.1 # SIMILARITY Belongs to the FliP/MopC/SpaP family. {ECO 0000305}. # SUBCELLULAR LOCATION FLIP_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. Bacterial flagellum basal body {ECO 0000269|PubMed 15919996}. # TIGRFAMs TIGR01103 fliP # eggNOG COG1338 LUCA # eggNOG ENOG4105CN7 Bacteria BLAST swissprot:FLIP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLIP_ECOLI BioCyc ECOL316407:JW1932-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1932-MONOMER BioCyc EcoCyc:EG11975-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11975-MONOMER COG COG1338 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1338 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L22182 http://www.ebi.ac.uk/ena/data/view/L22182 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1918 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1918 EcoGene EG11975 http://www.ecogene.org/geneInfo.php?eg_id=EG11975 EnsemblBacteria AAC75015 http://www.ensemblgenomes.org/id/AAC75015 EnsemblBacteria AAC75015 http://www.ensemblgenomes.org/id/AAC75015 EnsemblBacteria BAA15773 http://www.ensemblgenomes.org/id/BAA15773 EnsemblBacteria BAA15773 http://www.ensemblgenomes.org/id/BAA15773 EnsemblBacteria BAA15773 http://www.ensemblgenomes.org/id/BAA15773 EnsemblBacteria b1948 http://www.ensemblgenomes.org/id/b1948 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0009425 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009425 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0009306 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009306 GO_process GO:0044781 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044781 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 946462 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946462 HOGENOM HOG000253558 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000253558&db=HOGENOM6 InParanoid P0AC05 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AC05 InterPro IPR005837 http://www.ebi.ac.uk/interpro/entry/IPR005837 InterPro IPR005838 http://www.ebi.ac.uk/interpro/entry/IPR005838 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW1932 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1932 KEGG_Gene eco:b1948 http://www.genome.jp/dbget-bin/www_bget?eco:b1948 KEGG_Orthology KO:K02419 http://www.genome.jp/dbget-bin/www_bget?KO:K02419 KEGG_Pathway ko02040 http://www.genome.jp/kegg-bin/show_pathway?ko02040 OMA MPPNQIL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MPPNQIL PANTHER PTHR30587:SF0 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30587:SF0 PRINTS PR00951 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00951 PRINTS PR01302 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01302 PROSITE PS01060 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01060 PROSITE PS01061 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01061 PSORT swissprot:FLIP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLIP_ECOLI PSORT-B swissprot:FLIP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLIP_ECOLI PSORT2 swissprot:FLIP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLIP_ECOLI Pfam PF00813 http://pfam.xfam.org/family/PF00813 Phobius swissprot:FLIP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLIP_ECOLI PhylomeDB P0AC05 http://phylomedb.org/?seqid=P0AC05 ProteinModelPortal P0AC05 http://www.proteinmodelportal.org/query/uniprot/P0AC05 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8282695 http://www.ncbi.nlm.nih.gov/pubmed/8282695 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416458 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416458 RefSeq WP_001253441 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001253441 STRING 511145.b1948 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1948&targetmode=cogs STRING COG1338 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1338&targetmode=cogs TIGRFAMs TIGR01103 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01103 UniProtKB FLIP_ECOLI http://www.uniprot.org/uniprot/FLIP_ECOLI UniProtKB-AC P0AC05 http://www.uniprot.org/uniprot/P0AC05 charge swissprot:FLIP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLIP_ECOLI eggNOG COG1338 http://eggnogapi.embl.de/nog_data/html/tree/COG1338 eggNOG ENOG4105CN7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CN7 epestfind swissprot:FLIP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLIP_ECOLI garnier swissprot:FLIP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLIP_ECOLI helixturnhelix swissprot:FLIP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLIP_ECOLI hmoment swissprot:FLIP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLIP_ECOLI iep swissprot:FLIP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLIP_ECOLI inforesidue swissprot:FLIP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLIP_ECOLI octanol swissprot:FLIP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLIP_ECOLI pepcoil swissprot:FLIP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLIP_ECOLI pepdigest swissprot:FLIP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLIP_ECOLI pepinfo swissprot:FLIP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLIP_ECOLI pepnet swissprot:FLIP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLIP_ECOLI pepstats swissprot:FLIP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLIP_ECOLI pepwheel swissprot:FLIP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLIP_ECOLI pepwindow swissprot:FLIP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLIP_ECOLI sigcleave swissprot:FLIP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLIP_ECOLI ## Database ID URL or Descriptions # AltName ATP GTP 3'-pyrophosphotransferase # AltName SPOT_ECOLI (p)ppGpp synthase # AltName SPOT_ECOLI Penta-phosphate guanosine-3'-pyrophosphohydrolase # AltName SPOT_ECOLI Stringent response-like protein # AltName SPOT_ECOLI ppGpp synthase II # AltName SPOT_ECOLI ppGpp synthase II # BioGrid 4259361 487 # CATALYTIC ACTIVITY SPOT_ECOLI ATP + GTP = AMP + guanosine 3'-diphosphate 5'- triphosphate. # CATALYTIC ACTIVITY SPOT_ECOLI Guanosine 3',5'-bis(diphosphate) + H(2)O = guanosine 5'-diphosphate + diphosphate. # CDD cd01668 TGS_RelA_SpoT # CDD cd05399 NT_Rel-Spo_like # COFACTOR Name=Mn(2+); Xref=ChEBI:CHEBI 29035; # DISRUPTION PHENOTYPE SPOT_ECOLI In the presence of wild-type relA, spoT cannot be deleted because ppGpp accumulation is toxic. In the double relA/spoT deletion (a ppGpp0 mutant) there is a very large increase in biofilm formation (in a csrA-disrupted background) (PubMed 19460094). The double relA/spoT deletion obviates persister cell formation in a hipA7 mutant (PubMed 14622409, PubMed 26051177). {ECO 0000269|PubMed 14622409, ECO 0000269|PubMed 19460094, ECO 0000269|PubMed 26051177}. # EcoGene EG10966 spoT # FUNCTION SPOT_ECOLI In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes both the synthesis and degradation of ppGpp. The second messengers ppGpp and c-di-GMP together control biofilm formation in response to translational stress; ppGpp represses biofilm formation while c- di-GMP induces it. {ECO 0000269|PubMed 14622409, ECO 0000269|PubMed 19460094}. # GO_component GO:0005618 cell wall; IBA:GO_Central. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005886 plasma membrane; IBA:GO_Central. # GO_function GO:0008728 GTP diphosphokinase activity; IBA:GO_Central. # GO_function GO:0008893 guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity; IDA:EcoCyc. # GO_function GO:0016301 kinase activity; IEA:UniProtKB-KW. # GO_function GO:0016597 amino acid binding; IEA:InterPro. # GO_process GO:0015949 nucleobase-containing small molecule interconversion; IMP:EcoCyc. # GO_process GO:0015970 guanosine tetraphosphate biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005618 cell wall # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.10.20.30 -; 1. # INTERACTION SPOT_ECOLI P0A6A8 acpP; NbExp=5; IntAct=EBI-543228, EBI-542566; # IntAct P0AG24 59 # InterPro IPR002912 ACT_dom # InterPro IPR003607 HD/PDEase_dom # InterPro IPR004095 TGS # InterPro IPR004811 RelA/Spo_fam # InterPro IPR007685 RelA_SpoT # InterPro IPR012675 Beta-grasp_dom # InterPro IPR012676 TGS-like # InterPro IPR033655 TGS_RelA # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # KEGG_Pathway ko00230 Purine metabolism # Organism SPOT_ECOLI Escherichia coli (strain K12) # PATHWAY Purine metabolism; ppGpp biosynthesis; ppGpp from GDP step 1/1. # PATHWAY Purine metabolism; ppGpp biosynthesis; ppGpp from GTP step 1/2. # PATRIC 32122787 VBIEscCol129921_3770 # PIR B30374 SHECGD # PROSITE PS51671 ACT # Pfam PF02824 TGS # Pfam PF04607 RelA_SpoT # Pfam PF13291 ACT_4 # Pfam PF13328 HD_4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SPOT_ECOLI Bifunctional (p)ppGpp synthase/hydrolase SpoT # RecName SPOT_ECOLI Bifunctional (p)ppGpp synthase/hydrolase SpoT # RecName SPOT_ECOLI GTP pyrophosphokinase # RecName SPOT_ECOLI Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase # RefSeq NP_418107 NC_000913.3 # RefSeq WP_000280488 NZ_LN832404.1 # SIMILARITY Belongs to the RelA/SpoT family. {ECO 0000305}. # SIMILARITY Contains 1 ACT domain. {ECO:0000255|PROSITE- ProRule PRU01007}. # SIMILARITY Contains 1 HD domain. {ECO 0000305}. # SMART SM00471 HDc # SMART SM00954 RelA_SpoT # SUBCELLULAR LOCATION SPOT_ECOLI Cytoplasm {ECO 0000269|PubMed 17616600}. Note=Is associated with pre-50S ribosomal subunits in a salt- dependent manner. # SUBUNIT Interacts with ObgE/CgtA (AC P42641); this association is not required for pre-50S ribosome binding. Under both amino acid and carbon starvation conditions about half of the protein dissociates from the ribosome. {ECO:0000269|PubMed 15292126}. # SUPFAM SSF81271 SSF81271 # TIGRFAMs TIGR00691 spoT_relA # UniPathway UPA00908 UER00884 # UniPathway UPA00908 UER00886 # eggNOG COG0317 LUCA # eggNOG ENOG4105CWR Bacteria BLAST swissprot:SPOT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SPOT_ECOLI BioCyc ECOL316407:JW3625-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3625-MONOMER BioCyc EcoCyc:SPOT-MONOMER http://biocyc.org/getid?id=EcoCyc:SPOT-MONOMER BioCyc MetaCyc:SPOT-MONOMER http://biocyc.org/getid?id=MetaCyc:SPOT-MONOMER COG COG0317 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0317 DIP DIP-29378N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-29378N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1016/j.molcel.2015.05.011 http://dx.doi.org/10.1016/j.molcel.2015.05.011 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2003.03779.x http://dx.doi.org/10.1046/j.1365-2958.2003.03779.x DOI 10.1111/j.1365-2958.2009.06739.x http://dx.doi.org/10.1111/j.1365-2958.2009.06739.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00315-07 http://dx.doi.org/10.1128/JB.00315-07 DOI 10.1128/JB.186.16.5249-5257.2004 http://dx.doi.org/10.1128/JB.186.16.5249-5257.2004 DOI 10.1271/bbb.66.2735 http://dx.doi.org/10.1271/bbb.66.2735 EC_number EC:2.7.6.5 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.6.5 EC_number EC:3.1.7.2 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.7.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M24503 http://www.ebi.ac.uk/ena/data/view/M24503 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.6.5 http://enzyme.expasy.org/EC/2.7.6.5 ENZYME 3.1.7.2 http://enzyme.expasy.org/EC/3.1.7.2 EchoBASE EB0959 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0959 EcoGene EG10966 http://www.ecogene.org/geneInfo.php?eg_id=EG10966 EnsemblBacteria AAC76674 http://www.ensemblgenomes.org/id/AAC76674 EnsemblBacteria AAC76674 http://www.ensemblgenomes.org/id/AAC76674 EnsemblBacteria BAE77643 http://www.ensemblgenomes.org/id/BAE77643 EnsemblBacteria BAE77643 http://www.ensemblgenomes.org/id/BAE77643 EnsemblBacteria BAE77643 http://www.ensemblgenomes.org/id/BAE77643 EnsemblBacteria b3650 http://www.ensemblgenomes.org/id/b3650 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005618 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0008728 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008728 GO_function GO:0008893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008893 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_function GO:0016597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016597 GO_process GO:0015949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015949 GO_process GO:0015970 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015970 GOslim_component GO:0005618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005618 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.10.20.30 http://www.cathdb.info/version/latest/superfamily/3.10.20.30 GeneID 948159 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948159 HOGENOM HOG000018299 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000018299&db=HOGENOM6 InParanoid P0AG24 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AG24 IntAct P0AG24 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AG24* IntEnz 2.7.6.5 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.6.5 IntEnz 3.1.7.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.7.2 InterPro IPR002912 http://www.ebi.ac.uk/interpro/entry/IPR002912 InterPro IPR003607 http://www.ebi.ac.uk/interpro/entry/IPR003607 InterPro IPR004095 http://www.ebi.ac.uk/interpro/entry/IPR004095 InterPro IPR004811 http://www.ebi.ac.uk/interpro/entry/IPR004811 InterPro IPR007685 http://www.ebi.ac.uk/interpro/entry/IPR007685 InterPro IPR012675 http://www.ebi.ac.uk/interpro/entry/IPR012675 InterPro IPR012676 http://www.ebi.ac.uk/interpro/entry/IPR012676 InterPro IPR033655 http://www.ebi.ac.uk/interpro/entry/IPR033655 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW3625 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3625 KEGG_Gene eco:b3650 http://www.genome.jp/dbget-bin/www_bget?eco:b3650 KEGG_Orthology KO:K01139 http://www.genome.jp/dbget-bin/www_bget?KO:K01139 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Reaction rn:R00336 http://www.genome.jp/dbget-bin/www_bget?rn:R00336 MINT MINT-1219858 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1219858 OMA HGITIHR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HGITIHR PROSITE PS51671 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51671 PSORT swissprot:SPOT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SPOT_ECOLI PSORT-B swissprot:SPOT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SPOT_ECOLI PSORT2 swissprot:SPOT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SPOT_ECOLI Pfam PF02824 http://pfam.xfam.org/family/PF02824 Pfam PF04607 http://pfam.xfam.org/family/PF04607 Pfam PF13291 http://pfam.xfam.org/family/PF13291 Pfam PF13328 http://pfam.xfam.org/family/PF13328 Phobius swissprot:SPOT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SPOT_ECOLI PhylomeDB P0AG24 http://phylomedb.org/?seqid=P0AG24 ProteinModelPortal P0AG24 http://www.proteinmodelportal.org/query/uniprot/P0AG24 PubMed 12596879 http://www.ncbi.nlm.nih.gov/pubmed/12596879 PubMed 14622409 http://www.ncbi.nlm.nih.gov/pubmed/14622409 PubMed 15292126 http://www.ncbi.nlm.nih.gov/pubmed/15292126 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17616600 http://www.ncbi.nlm.nih.gov/pubmed/17616600 PubMed 19460094 http://www.ncbi.nlm.nih.gov/pubmed/19460094 PubMed 2005134 http://www.ncbi.nlm.nih.gov/pubmed/2005134 PubMed 2549050 http://www.ncbi.nlm.nih.gov/pubmed/2549050 PubMed 26051177 http://www.ncbi.nlm.nih.gov/pubmed/26051177 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418107 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418107 RefSeq WP_000280488 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000280488 SMART SM00471 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00471 SMART SM00954 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00954 SMR P0AG24 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AG24 STRING 511145.b3650 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3650&targetmode=cogs STRING COG0317 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0317&targetmode=cogs SUPFAM SSF81271 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81271 TIGRFAMs TIGR00691 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00691 UniProtKB SPOT_ECOLI http://www.uniprot.org/uniprot/SPOT_ECOLI UniProtKB-AC P0AG24 http://www.uniprot.org/uniprot/P0AG24 charge swissprot:SPOT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SPOT_ECOLI eggNOG COG0317 http://eggnogapi.embl.de/nog_data/html/tree/COG0317 eggNOG ENOG4105CWR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CWR epestfind swissprot:SPOT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SPOT_ECOLI garnier swissprot:SPOT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SPOT_ECOLI helixturnhelix swissprot:SPOT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SPOT_ECOLI hmoment swissprot:SPOT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SPOT_ECOLI iep swissprot:SPOT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SPOT_ECOLI inforesidue swissprot:SPOT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SPOT_ECOLI octanol swissprot:SPOT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SPOT_ECOLI pepcoil swissprot:SPOT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SPOT_ECOLI pepdigest swissprot:SPOT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SPOT_ECOLI pepinfo swissprot:SPOT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SPOT_ECOLI pepnet swissprot:SPOT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SPOT_ECOLI pepstats swissprot:SPOT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SPOT_ECOLI pepwheel swissprot:SPOT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SPOT_ECOLI pepwindow swissprot:SPOT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SPOT_ECOLI sigcleave swissprot:SPOT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SPOT_ECOLI ## Database ID URL or Descriptions # CDD cd01425 RPS2 # EcoGene EG10901 rpsB # FUNCTION RS2_ECOLI Required for ribosomal protein S1 to bind to the 30S subunit. {ECO 0000269|PubMed 12068815}. # GO_component GO:0022627 cytosolic small ribosomal subunit; IDA:EcoliWiki. # GO_function GO:0003735 structural constituent of ribosome; IBA:GO_Central. # GO_function GO:0008270 zinc ion binding; IDA:EcoliWiki. # GO_process GO:0006412 translation; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006412 translation # HAMAP MF_00291_B Ribosomal_S2_B # INTERACTION RS2_ECOLI P0ACG8 hslR; NbExp=2; IntAct=EBI-543439, EBI-562824; # IntAct P0A7V0 206 # InterPro IPR001865 Ribosomal_S2 # InterPro IPR005706 Ribosomal_S2_bac/mit/plastid # InterPro IPR018130 Ribosomal_S2_CS # InterPro IPR023591 Ribosomal_S2_flav_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 M00179 Ribosome, archaea # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=26610.5; Method=MALDI; Range=2-241; Evidence={ECO:0000269|PubMed 10094780}; # Organism RS2_ECOLI Escherichia coli (strain K12) # PANTHER PTHR12534 PTHR12534 # PATRIC 32115445 VBIEscCol129921_0174 # PDB 1M5G Model; -; B=6-214 # PDB 2YKR EM; 9.80 A; B=9-226 # PDB 3J9Y EM; 3.90 A; b=1-240 # PDB 3J9Z EM; 3.60 A; SB=2-241 # PDB 3JA1 EM; 3.60 A; SB=2-241 # PDB 3JBU EM; 3.64 A; B=1-241 # PDB 3JBV EM; 3.32 A; B=1-241 # PDB 3JCD EM; 3.70 A; b=1-241 # PDB 3JCE EM; 3.20 A; b=1-241 # PDB 3JCJ EM; 3.70 A; j=1-241 # PDB 3JCN EM; 4.60 A; d=1-241 # PDB 4A2I EM; 16.50 A; B=9-226 # PDB 4ADV EM; 13.50 A; B=2-241 # PDB 4ODL X-ray; 2.92 A; C/D/E/F=20-34 # PDB 4ODM X-ray; 1.75 A; E/F/G/H/I/J/K/L/M=20-34 # PDB 4ODN X-ray; 1.60 A; B=26-41 # PDB 4ODP X-ray; 1.75 A; B=20-34 # PDB 4U1U X-ray; 2.95 A; AB/CB=9-226 # PDB 4U1V X-ray; 3.00 A; AB/CB=9-226 # PDB 4U20 X-ray; 2.90 A; AB/CB=9-226 # PDB 4U24 X-ray; 2.90 A; AB/CB=9-226 # PDB 4U25 X-ray; 2.90 A; AB/CB=9-226 # PDB 4U26 X-ray; 2.80 A; AB/CB=9-226 # PDB 4U27 X-ray; 2.80 A; AB/CB=9-226 # PDB 4V48 EM; 11.50 A; BB=2-241 # PDB 4V4H X-ray; 3.46 A; AB/CB=1-241 # PDB 4V4Q X-ray; 3.46 A; AB/CB=2-241 # PDB 4V4V EM; 15.00 A; AB=6-241 # PDB 4V4W EM; 15.00 A; AB=6-241 # PDB 4V50 X-ray; 3.22 A; AB/CB=2-241 # PDB 4V52 X-ray; 3.21 A; AB/CB=2-241 # PDB 4V53 X-ray; 3.54 A; AB/CB=2-241 # PDB 4V54 X-ray; 3.30 A; AB/CB=2-241 # PDB 4V55 X-ray; 4.00 A; AB/CB=2-241 # PDB 4V56 X-ray; 3.93 A; AB/CB=2-241 # PDB 4V57 X-ray; 3.50 A; AB/CB=2-241 # PDB 4V5B X-ray; 3.74 A; BB/DB=2-241 # PDB 4V5H EM; 5.80 A; AB=9-226 # PDB 4V5Y X-ray; 4.45 A; AB/CB=2-241 # PDB 4V64 X-ray; 3.50 A; AB/CB=2-241 # PDB 4V65 EM; 9.00 A; AB=1-241 # PDB 4V66 EM; 9.00 A; AB=1-241 # PDB 4V69 EM; 6.70 A; AB=9-226 # PDB 4V6C X-ray; 3.19 A; AB/CB=1-241 # PDB 4V6D X-ray; 3.81 A; AB/CB=1-241 # PDB 4V6E X-ray; 3.71 A; AB/CB=1-241 # PDB 4V6K EM; 8.25 A; BF=1-241 # PDB 4V6L EM; 13.20 A; AF=1-241 # PDB 4V6M EM; 7.10 A; AB=2-241 # PDB 4V6N EM; 12.10 A; BE=2-241 # PDB 4V6O EM; 14.70 A; AE=2-241 # PDB 4V6P EM; 13.50 A; AE=2-241 # PDB 4V6Q EM; 11.50 A; AE=2-241 # PDB 4V6R EM; 11.50 A; AE=2-241 # PDB 4V6S EM; 13.10 A; BD=2-241 # PDB 4V6T EM; 8.30 A; AB=9-226 # PDB 4V6V EM; 9.80 A; AB=2-241 # PDB 4V6Y EM; 12.00 A; AB=9-226 # PDB 4V6Z EM; 12.00 A; AB=9-226 # PDB 4V70 EM; 17.00 A; AB=9-226 # PDB 4V71 EM; 20.00 A; AB=9-226 # PDB 4V72 EM; 13.00 A; AB=9-226 # PDB 4V73 EM; 15.00 A; AB=9-226 # PDB 4V74 EM; 17.00 A; AB=9-226 # PDB 4V75 EM; 12.00 A; AB=9-226 # PDB 4V76 EM; 17.00 A; AB=9-226 # PDB 4V77 EM; 17.00 A; AB=9-226 # PDB 4V78 EM; 20.00 A; AB=9-226 # PDB 4V79 EM; 15.00 A; AB=9-226 # PDB 4V7A EM; 9.00 A; AB=9-226 # PDB 4V7B EM; 6.80 A; AB=1-241 # PDB 4V7C EM; 7.60 A; AB=2-241 # PDB 4V7D EM; 7.60 A; BB=2-241 # PDB 4V7I EM; 9.60 A; BB=1-241 # PDB 4V7S X-ray; 3.25 A; AB/CB=9-226 # PDB 4V7T X-ray; 3.19 A; AB/CB=9-226 # PDB 4V7U X-ray; 3.10 A; AB/CB=9-226 # PDB 4V7V X-ray; 3.29 A; AB/CB=9-226 # PDB 4V85 X-ray; 3.20 A; B=1-241 # PDB 4V89 X-ray; 3.70 A; AB=1-241 # PDB 4V9C X-ray; 3.30 A; AB/CB=1-241 # PDB 4V9D X-ray; 3.00 A; AB/BB=9-226 # PDB 4V9O X-ray; 2.90 A; BB/DB/FB/HB=1-241 # PDB 4V9P X-ray; 2.90 A; BB/DB/FB/HB=1-241 # PDB 4WF1 X-ray; 3.09 A; AB/CB=9-226 # PDB 4WOI X-ray; 3.00 A; AB/DB=1-241 # PDB 4WWW X-ray; 3.10 A; QB/XB=9-226 # PDB 4YBB X-ray; 2.10 A; AB/BB=4-227 # PDB 5AFI EM; 2.90 A; b=1-240 # PDB 5IQR EM; 3.00 A; g=1-241 # PDB 5IT8 X-ray; 3.12 A; AB/BB=4-227 # PDB 5J5B X-ray; 2.80 A; AB/BB=4-227 # PDB 5J7L X-ray; 3.00 A; AB/BB=4-227 # PDB 5J88 X-ray; 3.32 A; AB/BB=4-227 # PDB 5J8A X-ray; 3.10 A; AB/BB=4-227 # PDB 5J91 X-ray; 2.96 A; AB/BB=4-227 # PDB 5JC9 X-ray; 3.03 A; AB/BB=4-227 # PDB 5JTE EM; 3.60 A; AB=1-240 # PDB 5JU8 EM; 3.60 A; AB=1-240 # PDB 5KCR EM; 3.60 A; 1b=1-241 # PDB 5KCS EM; 3.90 A; 1b=1-241 # PDB 5KPS EM; 3.90 A; 7=1-241 # PDB 5KPV EM; 4.10 A; 6=1-241 # PDB 5KPW EM; 3.90 A; 6=1-241 # PDB 5KPX EM; 3.90 A; 6=1-241 # PDB 5L3P EM; 3.70 A; b=1-240 # PIR A02696 R3EC2 # PRINTS PR00395 RIBOSOMALS2 # PROSITE PS00962 RIBOSOMAL_S2_1 # PROSITE PS00963 RIBOSOMAL_S2_2 # Pfam PF00318 Ribosomal_S2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RS2_ECOLI 30S ribosomal protein S2 # RefSeq NP_414711 NC_000913.3 # RefSeq WP_000246882 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein S2P family. {ECO 0000305}. # SUBUNIT RS2_ECOLI Part of the 30S ribosomal subunit, contacts S1. Some nascent polypeptide chains are able to cross-link to this protein in situ. {ECO 0000269|PubMed 12068815, ECO 0000269|PubMed 12809609, ECO 0000269|PubMed 16272117, ECO 0000269|PubMed 9716382}. # SUPFAM SSF52313 SSF52313 # TIGRFAMs TIGR01011 rpsB_bact # eggNOG COG0052 LUCA # eggNOG ENOG4105CE9 Bacteria BLAST swissprot:RS2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RS2_ECOLI BioCyc ECOL316407:JW0164-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0164-MONOMER BioCyc EcoCyc:EG10901-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10901-MONOMER BioCyc MetaCyc:EG10901-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10901-MONOMER COG COG0052 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0052 DIP DIP-6877N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-6877N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1016/0006-291X(92)90636-Y http://dx.doi.org/10.1016/0006-291X(92)90636-Y DOI 10.1016/0014-5793(81)80743-0 http://dx.doi.org/10.1016/0014-5793(81)80743-0 DOI 10.1016/S0092-8674(03)00427-6 http://dx.doi.org/10.1016/S0092-8674(03)00427-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nchembio.495 http://dx.doi.org/10.1038/nchembio.495 DOI 10.1038/nsb841 http://dx.doi.org/10.1038/nsb841 DOI 10.1046/j.1365-2958.2002.02971.x http://dx.doi.org/10.1046/j.1365-2958.2002.02971.x DOI 10.1046/j.1432-1327.1998.2550409.x http://dx.doi.org/10.1046/j.1432-1327.1998.2550409.x DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1093/nar/9.16.4163 http://dx.doi.org/10.1093/nar/9.16.4163 DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EMBL V00343 http://www.ebi.ac.uk/ena/data/view/V00343 EchoBASE EB0894 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0894 EcoGene EG10901 http://www.ecogene.org/geneInfo.php?eg_id=EG10901 EnsemblBacteria AAC73280 http://www.ensemblgenomes.org/id/AAC73280 EnsemblBacteria AAC73280 http://www.ensemblgenomes.org/id/AAC73280 EnsemblBacteria BAB96744 http://www.ensemblgenomes.org/id/BAB96744 EnsemblBacteria BAB96744 http://www.ensemblgenomes.org/id/BAB96744 EnsemblBacteria BAB96744 http://www.ensemblgenomes.org/id/BAB96744 EnsemblBacteria b0169 http://www.ensemblgenomes.org/id/b0169 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0022627 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022627 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GeneID 947874 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947874 HAMAP MF_00291_B http://hamap.expasy.org/unirule/MF_00291_B HOGENOM HOG000071892 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000071892&db=HOGENOM6 InParanoid P0A7V0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7V0 IntAct P0A7V0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7V0* InterPro IPR001865 http://www.ebi.ac.uk/interpro/entry/IPR001865 InterPro IPR005706 http://www.ebi.ac.uk/interpro/entry/IPR005706 InterPro IPR018130 http://www.ebi.ac.uk/interpro/entry/IPR018130 InterPro IPR023591 http://www.ebi.ac.uk/interpro/entry/IPR023591 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW0164 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0164 KEGG_Gene eco:b0169 http://www.genome.jp/dbget-bin/www_bget?eco:b0169 KEGG_Orthology KO:K02967 http://www.genome.jp/dbget-bin/www_bget?KO:K02967 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 OMA RIPDILY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RIPDILY PANTHER PTHR12534 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12534 PDB 1M5G http://www.ebi.ac.uk/pdbe-srv/view/entry/1M5G PDB 2YKR http://www.ebi.ac.uk/pdbe-srv/view/entry/2YKR PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 4A2I http://www.ebi.ac.uk/pdbe-srv/view/entry/4A2I PDB 4ADV http://www.ebi.ac.uk/pdbe-srv/view/entry/4ADV PDB 4ODL http://www.ebi.ac.uk/pdbe-srv/view/entry/4ODL PDB 4ODM http://www.ebi.ac.uk/pdbe-srv/view/entry/4ODM PDB 4ODN http://www.ebi.ac.uk/pdbe-srv/view/entry/4ODN PDB 4ODP http://www.ebi.ac.uk/pdbe-srv/view/entry/4ODP PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4V48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V48 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 1M5G http://www.ebi.ac.uk/pdbsum/1M5G PDBsum 2YKR http://www.ebi.ac.uk/pdbsum/2YKR PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 4A2I http://www.ebi.ac.uk/pdbsum/4A2I PDBsum 4ADV http://www.ebi.ac.uk/pdbsum/4ADV PDBsum 4ODL http://www.ebi.ac.uk/pdbsum/4ODL PDBsum 4ODM http://www.ebi.ac.uk/pdbsum/4ODM PDBsum 4ODN http://www.ebi.ac.uk/pdbsum/4ODN PDBsum 4ODP http://www.ebi.ac.uk/pdbsum/4ODP PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4V48 http://www.ebi.ac.uk/pdbsum/4V48 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PRINTS PR00395 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00395 PROSITE PS00962 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00962 PROSITE PS00963 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00963 PSORT swissprot:RS2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RS2_ECOLI PSORT-B swissprot:RS2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RS2_ECOLI PSORT2 swissprot:RS2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RS2_ECOLI Pfam PF00318 http://pfam.xfam.org/family/PF00318 Phobius swissprot:RS2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RS2_ECOLI PhylomeDB P0A7V0 http://phylomedb.org/?seqid=P0A7V0 ProteinModelPortal P0A7V0 http://www.proteinmodelportal.org/query/uniprot/P0A7V0 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 12068815 http://www.ncbi.nlm.nih.gov/pubmed/12068815 PubMed 12244297 http://www.ncbi.nlm.nih.gov/pubmed/12244297 PubMed 12809609 http://www.ncbi.nlm.nih.gov/pubmed/12809609 PubMed 1575737 http://www.ncbi.nlm.nih.gov/pubmed/1575737 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21151122 http://www.ncbi.nlm.nih.gov/pubmed/21151122 PubMed 6272196 http://www.ncbi.nlm.nih.gov/pubmed/6272196 PubMed 7023985 http://www.ncbi.nlm.nih.gov/pubmed/7023985 PubMed 7556101 http://www.ncbi.nlm.nih.gov/pubmed/7556101 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9716382 http://www.ncbi.nlm.nih.gov/pubmed/9716382 RefSeq NP_414711 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414711 RefSeq WP_000246882 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000246882 SMR P0A7V0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7V0 STRING 511145.b0169 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0169&targetmode=cogs STRING COG0052 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0052&targetmode=cogs SUPFAM SSF52313 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52313 SWISS-2DPAGE P0A7V0 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A7V0 TIGRFAMs TIGR01011 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01011 UniProtKB RS2_ECOLI http://www.uniprot.org/uniprot/RS2_ECOLI UniProtKB-AC P0A7V0 http://www.uniprot.org/uniprot/P0A7V0 charge swissprot:RS2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RS2_ECOLI eggNOG COG0052 http://eggnogapi.embl.de/nog_data/html/tree/COG0052 eggNOG ENOG4105CE9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CE9 epestfind swissprot:RS2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RS2_ECOLI garnier swissprot:RS2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RS2_ECOLI helixturnhelix swissprot:RS2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RS2_ECOLI hmoment swissprot:RS2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RS2_ECOLI iep swissprot:RS2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RS2_ECOLI inforesidue swissprot:RS2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RS2_ECOLI octanol swissprot:RS2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RS2_ECOLI pepcoil swissprot:RS2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RS2_ECOLI pepdigest swissprot:RS2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RS2_ECOLI pepinfo swissprot:RS2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RS2_ECOLI pepnet swissprot:RS2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RS2_ECOLI pepstats swissprot:RS2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RS2_ECOLI pepwheel swissprot:RS2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RS2_ECOLI pepwindow swissprot:RS2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RS2_ECOLI sigcleave swissprot:RS2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RS2_ECOLI ## Database ID URL or Descriptions # BioGrid 4263532 351 # EcoGene EG11096 yajC # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0031522 cell envelope Sec protein transport complex; IPI:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043234 protein complex # InterPro IPR003849 Preprotein_translocase_YajC # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02044 M00335 Sec (secretion) system # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko03060 Protein export # KEGG_Pathway ko03070 Bacterial secretion system # Organism YAJC_ECOLI Escherichia coli (strain K12) # PATRIC 32115963 VBIEscCol129921_0423 # PDB 2RDD X-ray; 3.50 A; B=19-55 # PIR D38530 D38530 # PRINTS PR01853 YAJCTRNLCASE # Pfam PF02699 YajC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAJC_ECOLI UPF0092 membrane protein YajC # RefSeq NP_414941 NC_000913.3 # RefSeq WP_000007629 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0092 family. {ECO 0000305}. # SMART SM01323 YajC # SUBCELLULAR LOCATION YAJC_ECOLI Cell inner membrane {ECO 0000269|PubMed 16079137}; Single-pass membrane protein {ECO 0000269|PubMed 16079137}. # SUBUNIT Part of the SecDF-YidC-YajC translocase complex; YajC is also present in a homooligomeric complex in excess of the other components. {ECO:0000269|PubMed 16079137}. # TCDB 3.A.5.1 the general secretory pathway (sec) family # TIGRFAMs TIGR00739 yajC # eggNOG COG1862 LUCA # eggNOG ENOG4105VIE Bacteria BLAST swissprot:YAJC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAJC_ECOLI BioCyc ECOL316407:JW0397-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0397-MONOMER BioCyc EcoCyc:EG11096-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11096-MONOMER COG COG1862 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1862 DIP DIP-29531N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-29531N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M63939 http://www.ebi.ac.uk/ena/data/view/M63939 EMBL S68715 http://www.ebi.ac.uk/ena/data/view/S68715 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL X56175 http://www.ebi.ac.uk/ena/data/view/X56175 EchoBASE EB1088 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1088 EcoGene EG11096 http://www.ecogene.org/geneInfo.php?eg_id=EG11096 EnsemblBacteria AAC73510 http://www.ensemblgenomes.org/id/AAC73510 EnsemblBacteria AAC73510 http://www.ensemblgenomes.org/id/AAC73510 EnsemblBacteria BAE76187 http://www.ensemblgenomes.org/id/BAE76187 EnsemblBacteria BAE76187 http://www.ensemblgenomes.org/id/BAE76187 EnsemblBacteria BAE76187 http://www.ensemblgenomes.org/id/BAE76187 EnsemblBacteria b0407 http://www.ensemblgenomes.org/id/b0407 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0031522 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031522 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GeneID 945374 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945374 HOGENOM HOG000018859 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000018859&db=HOGENOM6 InParanoid P0ADZ7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADZ7 IntAct P0ADZ7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADZ7* InterPro IPR003849 http://www.ebi.ac.uk/interpro/entry/IPR003849 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW0397 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0397 KEGG_Gene eco:b0407 http://www.genome.jp/dbget-bin/www_bget?eco:b0407 KEGG_Orthology KO:K03210 http://www.genome.jp/dbget-bin/www_bget?KO:K03210 KEGG_Pathway ko03060 http://www.genome.jp/kegg-bin/show_pathway?ko03060 KEGG_Pathway ko03070 http://www.genome.jp/kegg-bin/show_pathway?ko03070 OMA FFISSAW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FFISSAW PDB 2RDD http://www.ebi.ac.uk/pdbe-srv/view/entry/2RDD PDBsum 2RDD http://www.ebi.ac.uk/pdbsum/2RDD PRINTS PR01853 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01853 PSORT swissprot:YAJC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAJC_ECOLI PSORT-B swissprot:YAJC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAJC_ECOLI PSORT2 swissprot:YAJC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAJC_ECOLI Pfam PF02699 http://pfam.xfam.org/family/PF02699 Phobius swissprot:YAJC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAJC_ECOLI PhylomeDB P0ADZ7 http://phylomedb.org/?seqid=P0ADZ7 ProteinModelPortal P0ADZ7 http://www.proteinmodelportal.org/query/uniprot/P0ADZ7 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1706703 http://www.ncbi.nlm.nih.gov/pubmed/1706703 PubMed 2170107 http://www.ncbi.nlm.nih.gov/pubmed/2170107 PubMed 2249673 http://www.ncbi.nlm.nih.gov/pubmed/2249673 PubMed 7507921 http://www.ncbi.nlm.nih.gov/pubmed/7507921 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414941 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414941 RefSeq WP_000007629 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000007629 SMART SM01323 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01323 SMR P0ADZ7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADZ7 STRING 511145.b0407 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0407&targetmode=cogs STRING COG1862 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1862&targetmode=cogs TCDB 3.A.5.1 http://www.tcdb.org/search/result.php?tc=3.A.5.1 TIGRFAMs TIGR00739 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00739 UniProtKB YAJC_ECOLI http://www.uniprot.org/uniprot/YAJC_ECOLI UniProtKB-AC P0ADZ7 http://www.uniprot.org/uniprot/P0ADZ7 charge swissprot:YAJC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAJC_ECOLI eggNOG COG1862 http://eggnogapi.embl.de/nog_data/html/tree/COG1862 eggNOG ENOG4105VIE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VIE epestfind swissprot:YAJC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAJC_ECOLI garnier swissprot:YAJC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAJC_ECOLI helixturnhelix swissprot:YAJC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAJC_ECOLI hmoment swissprot:YAJC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAJC_ECOLI iep swissprot:YAJC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAJC_ECOLI inforesidue swissprot:YAJC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAJC_ECOLI octanol swissprot:YAJC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAJC_ECOLI pepcoil swissprot:YAJC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAJC_ECOLI pepdigest swissprot:YAJC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAJC_ECOLI pepinfo swissprot:YAJC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAJC_ECOLI pepnet swissprot:YAJC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAJC_ECOLI pepstats swissprot:YAJC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAJC_ECOLI pepwheel swissprot:YAJC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAJC_ECOLI pepwindow swissprot:YAJC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAJC_ECOLI sigcleave swissprot:YAJC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAJC_ECOLI ## Database ID URL or Descriptions # AltName TRUC_ECOLI tRNA pseudouridine(65) synthase # AltName TRUC_ECOLI tRNA pseudouridylate synthase C # AltName TRUC_ECOLI tRNA-uridine isomerase C # BioGrid 4262247 15 # CATALYTIC ACTIVITY tRNA uridine(65) = tRNA pseudouridine(65). {ECO:0000269|PubMed 11720289}. # EcoGene EG13171 truC # FUNCTION TRUC_ECOLI Responsible for synthesis of pseudouridine from uracil- 65 in transfer RNAs. {ECO 0000269|PubMed 11720289}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003723 RNA binding; IEA:InterPro. # GO_function GO:0009982 pseudouridine synthase activity; IMP:EcoCyc. # GO_process GO:0006399 tRNA metabolic process; IMP:EcoliWiki. # GO_process GO:0008033 tRNA processing; IMP:EcoliWiki. # GO_process GO:0009451 RNA modification; IMP:EcoliWiki. # GO_process GO:0031119 tRNA pseudouridine synthesis; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # InterPro IPR006145 PsdUridine_synth_RsuA/RluD # InterPro IPR006224 PsdUridine_synth_RluC/D_CS # InterPro IPR020103 PsdUridine_synth_cat_dom # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # Organism TRUC_ECOLI Escherichia coli (strain K12) # PATRIC 32120998 VBIEscCol129921_2891 # PIR C65061 C65061 # PROSITE PS01129 PSI_RLU # Pfam PF00849 PseudoU_synth_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TRUC_ECOLI tRNA pseudouridine synthase C # RefSeq NP_417271 NC_000913.3 # RefSeq WP_000890001 NZ_LN832404.1 # SIMILARITY Belongs to the pseudouridine synthase RluA family. {ECO 0000305}. # SUPFAM SSF55120 SSF55120 # eggNOG COG0564 LUCA # eggNOG ENOG4105DR9 Bacteria BLAST swissprot:TRUC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRUC_ECOLI BioCyc ECOL316407:JW2762-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2762-MONOMER BioCyc EcoCyc:G7449-MONOMER http://biocyc.org/getid?id=EcoCyc:G7449-MONOMER BioCyc MetaCyc:G7449-MONOMER http://biocyc.org/getid?id=MetaCyc:G7449-MONOMER COG COG0564 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0564 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.4.99.26 http://www.genome.jp/dbget-bin/www_bget?EC:5.4.99.26 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 ENZYME 5.4.99.26 http://enzyme.expasy.org/EC/5.4.99.26 EchoBASE EB2963 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2963 EcoGene EG13171 http://www.ecogene.org/geneInfo.php?eg_id=EG13171 EnsemblBacteria AAC75833 http://www.ensemblgenomes.org/id/AAC75833 EnsemblBacteria AAC75833 http://www.ensemblgenomes.org/id/AAC75833 EnsemblBacteria BAE76863 http://www.ensemblgenomes.org/id/BAE76863 EnsemblBacteria BAE76863 http://www.ensemblgenomes.org/id/BAE76863 EnsemblBacteria BAE76863 http://www.ensemblgenomes.org/id/BAE76863 EnsemblBacteria b2791 http://www.ensemblgenomes.org/id/b2791 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0009982 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009982 GO_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GO_process GO:0008033 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008033 GO_process GO:0009451 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009451 GO_process GO:0031119 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031119 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 947242 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947242 HOGENOM HOG000275920 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275920&db=HOGENOM6 InParanoid P0AA41 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AA41 IntAct P0AA41 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AA41* IntEnz 5.4.99.26 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.4.99.26 InterPro IPR006145 http://www.ebi.ac.uk/interpro/entry/IPR006145 InterPro IPR006224 http://www.ebi.ac.uk/interpro/entry/IPR006224 InterPro IPR020103 http://www.ebi.ac.uk/interpro/entry/IPR020103 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW2762 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2762 KEGG_Gene eco:b2791 http://www.genome.jp/dbget-bin/www_bget?eco:b2791 KEGG_Orthology KO:K06175 http://www.genome.jp/dbget-bin/www_bget?KO:K06175 OMA QHVFPIH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QHVFPIH PROSITE PS01129 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01129 PSORT swissprot:TRUC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRUC_ECOLI PSORT-B swissprot:TRUC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRUC_ECOLI PSORT2 swissprot:TRUC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRUC_ECOLI Pfam PF00849 http://pfam.xfam.org/family/PF00849 Phobius swissprot:TRUC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRUC_ECOLI PhylomeDB P0AA41 http://phylomedb.org/?seqid=P0AA41 ProteinModelPortal P0AA41 http://www.proteinmodelportal.org/query/uniprot/P0AA41 PubMed 11720289 http://www.ncbi.nlm.nih.gov/pubmed/11720289 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417271 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417271 RefSeq WP_000890001 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000890001 STRING 511145.b2791 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2791&targetmode=cogs STRING COG0564 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0564&targetmode=cogs SUPFAM SSF55120 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55120 UniProtKB TRUC_ECOLI http://www.uniprot.org/uniprot/TRUC_ECOLI UniProtKB-AC P0AA41 http://www.uniprot.org/uniprot/P0AA41 charge swissprot:TRUC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRUC_ECOLI eggNOG COG0564 http://eggnogapi.embl.de/nog_data/html/tree/COG0564 eggNOG ENOG4105DR9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DR9 epestfind swissprot:TRUC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRUC_ECOLI garnier swissprot:TRUC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRUC_ECOLI helixturnhelix swissprot:TRUC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRUC_ECOLI hmoment swissprot:TRUC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRUC_ECOLI iep swissprot:TRUC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRUC_ECOLI inforesidue swissprot:TRUC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRUC_ECOLI octanol swissprot:TRUC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRUC_ECOLI pepcoil swissprot:TRUC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRUC_ECOLI pepdigest swissprot:TRUC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRUC_ECOLI pepinfo swissprot:TRUC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRUC_ECOLI pepnet swissprot:TRUC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRUC_ECOLI pepstats swissprot:TRUC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRUC_ECOLI pepwheel swissprot:TRUC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRUC_ECOLI pepwindow swissprot:TRUC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRUC_ECOLI sigcleave swissprot:TRUC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRUC_ECOLI ## Database ID URL or Descriptions # AltName ASTA_ECOLI AOST # BioGrid 4262235 8 # CATALYTIC ACTIVITY ASTA_ECOLI Succinyl-CoA + L-arginine = CoA + N(2)- succinyl-L-arginine. # EcoGene EG13998 astA # FUNCTION ASTA_ECOLI Catalyzes the transfer of succinyl-CoA to arginine to produce N(2)-succinylarginine. {ECO 0000269|PubMed 9696779}. # GO_function GO:0008791 arginine N-succinyltransferase activity; IEA:UniProtKB-HAMAP. # GO_process GO:0019544 arginine catabolic process to glutamate; IEA:UniProtKB-HAMAP. # GO_process GO:0019545 arginine catabolic process to succinate; IEA:UniProtKB-UniPathway. # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # Gene3D 3.40.630.30 -; 2. # HAMAP MF_01171 AstA # INDUCTION By nitrogen starvation, and arginine. Induced at stationary phase by sigma S. {ECO:0000269|PubMed 12003934}. # IntAct P0AE37 6 # InterPro IPR007041 Arg_succinylTrfase_AstA/AruG # InterPro IPR016181 Acyl_CoA_acyltransferase # InterPro IPR017650 Arginine_N-succinylTrfase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00330 Arginine and proline metabolism # Organism ASTA_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine step 1/5. # PATRIC 32118803 VBIEscCol129921_1819 # PIR C64934 C64934 # Pfam PF04958 AstA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ASTA_ECOLI Arginine N-succinyltransferase # RefSeq NP_416261 NC_000913.3 # RefSeq WP_000989419 NZ_LN832404.1 # SIMILARITY Belongs to the arginine N-succinyltransferase family. {ECO 0000305}. # SUPFAM SSF55729 SSF55729 # TIGRFAMs TIGR03243 arg_catab_AOST # TIGRFAMs TIGR03244 arg_catab_AstA # UniPathway UPA00185 UER00279 # eggNOG COG3138 LUCA # eggNOG ENOG4105F4X Bacteria BLAST swissprot:ASTA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ASTA_ECOLI BioCyc ECOL316407:JW1736-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1736-MONOMER BioCyc EcoCyc:ARGSUCCTRAN-MONOMER http://biocyc.org/getid?id=EcoCyc:ARGSUCCTRAN-MONOMER BioCyc MetaCyc:ARGSUCCTRAN-MONOMER http://biocyc.org/getid?id=MetaCyc:ARGSUCCTRAN-MONOMER COG COG3138 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3138 DOI 10.1016/S0014-5793(03)01314-0 http://dx.doi.org/10.1016/S0014-5793(03)01314-0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.11.2940-2950.2002 http://dx.doi.org/10.1128/JB.184.11.2940-2950.2002 EC_number EC:2.3.1.109 http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.109 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.3.1.109 http://enzyme.expasy.org/EC/2.3.1.109 EchoBASE EB3754 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3754 EcoGene EG13998 http://www.ecogene.org/geneInfo.php?eg_id=EG13998 EnsemblBacteria AAC74817 http://www.ensemblgenomes.org/id/AAC74817 EnsemblBacteria AAC74817 http://www.ensemblgenomes.org/id/AAC74817 EnsemblBacteria BAE76517 http://www.ensemblgenomes.org/id/BAE76517 EnsemblBacteria BAE76517 http://www.ensemblgenomes.org/id/BAE76517 EnsemblBacteria BAE76517 http://www.ensemblgenomes.org/id/BAE76517 EnsemblBacteria b1747 http://www.ensemblgenomes.org/id/b1747 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008791 GO_process GO:0019544 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019544 GO_process GO:0019545 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019545 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 3.40.630.30 http://www.cathdb.info/version/latest/superfamily/3.40.630.30 GeneID 946261 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946261 HAMAP MF_01171 http://hamap.expasy.org/unirule/MF_01171 HOGENOM HOG000258231 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000258231&db=HOGENOM6 InParanoid P0AE37 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AE37 IntAct P0AE37 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AE37* IntEnz 2.3.1.109 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.109 InterPro IPR007041 http://www.ebi.ac.uk/interpro/entry/IPR007041 InterPro IPR016181 http://www.ebi.ac.uk/interpro/entry/IPR016181 InterPro IPR017650 http://www.ebi.ac.uk/interpro/entry/IPR017650 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1736 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1736 KEGG_Gene eco:b1747 http://www.genome.jp/dbget-bin/www_bget?eco:b1747 KEGG_Orthology KO:K00673 http://www.genome.jp/dbget-bin/www_bget?KO:K00673 KEGG_Pathway ko00330 http://www.genome.jp/kegg-bin/show_pathway?ko00330 KEGG_Reaction rn:R00832 http://www.genome.jp/dbget-bin/www_bget?rn:R00832 OMA PVLECHI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PVLECHI PSORT swissprot:ASTA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ASTA_ECOLI PSORT-B swissprot:ASTA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ASTA_ECOLI PSORT2 swissprot:ASTA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ASTA_ECOLI Pfam PF04958 http://pfam.xfam.org/family/PF04958 Phobius swissprot:ASTA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ASTA_ECOLI PhylomeDB P0AE37 http://phylomedb.org/?seqid=P0AE37 ProteinModelPortal P0AE37 http://www.proteinmodelportal.org/query/uniprot/P0AE37 PubMed 12003934 http://www.ncbi.nlm.nih.gov/pubmed/12003934 PubMed 14675764 http://www.ncbi.nlm.nih.gov/pubmed/14675764 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9696779 http://www.ncbi.nlm.nih.gov/pubmed/9696779 RefSeq NP_416261 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416261 RefSeq WP_000989419 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000989419 SMR P0AE37 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AE37 STRING 511145.b1747 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1747&targetmode=cogs STRING COG3138 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3138&targetmode=cogs SUPFAM SSF55729 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55729 TIGRFAMs TIGR03243 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03243 TIGRFAMs TIGR03244 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03244 UniProtKB ASTA_ECOLI http://www.uniprot.org/uniprot/ASTA_ECOLI UniProtKB-AC P0AE37 http://www.uniprot.org/uniprot/P0AE37 charge swissprot:ASTA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ASTA_ECOLI eggNOG COG3138 http://eggnogapi.embl.de/nog_data/html/tree/COG3138 eggNOG ENOG4105F4X http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F4X epestfind swissprot:ASTA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ASTA_ECOLI garnier swissprot:ASTA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ASTA_ECOLI helixturnhelix swissprot:ASTA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ASTA_ECOLI hmoment swissprot:ASTA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ASTA_ECOLI iep swissprot:ASTA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ASTA_ECOLI inforesidue swissprot:ASTA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ASTA_ECOLI octanol swissprot:ASTA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ASTA_ECOLI pepcoil swissprot:ASTA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ASTA_ECOLI pepdigest swissprot:ASTA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ASTA_ECOLI pepinfo swissprot:ASTA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ASTA_ECOLI pepnet swissprot:ASTA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ASTA_ECOLI pepstats swissprot:ASTA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ASTA_ECOLI pepwheel swissprot:ASTA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ASTA_ECOLI pepwindow swissprot:ASTA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ASTA_ECOLI sigcleave swissprot:ASTA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ASTA_ECOLI ## Database ID URL or Descriptions # AltName ATPE_ECOLI ATP synthase F1 sector epsilon subunit # AltName ATPE_ECOLI F-ATPase epsilon subunit # CDD cd12152 F1-ATPase_delta # EcoGene EG10100 atpC # FUNCTION ATPE_ECOLI Produces ATP from ADP in the presence of a proton gradient across the membrane. # GO_component GO:0045260 plasma membrane proton-transporting ATP synthase complex; IBA:GO_Central. # GO_component GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1); IDA:EcoliWiki. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0046933 proton-transporting ATP synthase activity, rotational mechanism; IDA:EcoCyc. # GO_process GO:0015986 ATP synthesis coupled proton transport; IBA:GO_Central. # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0055085 transmembrane transport # Gene3D 2.60.15.10 -; 1. # HAMAP MF_00530 ATP_synth_epsil_bac # INTERACTION ATPE_ECOLI P0ABA6 atpG; NbExp=4; IntAct=EBI-544362, EBI-544306; # IntAct P0A6E6 7 # InterPro IPR001469 ATP_synth_F1_dsu/esu # InterPro IPR020546 ATP_synth_F1_dsu/esu_N # InterPro IPR020547 ATP_synth_F1_dsu/esu_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko00194 Photosynthesis proteins # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00190 Oxidative phosphorylation # KEGG_Pathway ko00195 Photosynthesis # Organism ATPE_ECOLI Escherichia coli (strain K12) # PANTHER PTHR13822 PTHR13822 # PATRIC 32122959 VBIEscCol129921_3855 # PDB 1AQT X-ray; 2.30 A; A=4-139 # PDB 1BSH NMR; -; A=2-139 # PDB 1BSN NMR; -; A=2-139 # PDB 1FS0 X-ray; 2.10 A; E=2-139 # PDB 1QO1 X-ray; 3.90 A; J=4-139 # PDB 3OAA X-ray; 3.26 A; H/P/X/f=2-139 # PIR B90106 PWECE # Pfam PF00401 ATP-synt_DE # Pfam PF02823 ATP-synt_DE_N # ProDom PD000944 ATPase_F1-cplx_dsu/esu # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ATPE_ECOLI ATP synthase epsilon chain # RefSeq NP_418187 NC_000913.3 # RefSeq WP_001251965 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA23528.1; Type=Frameshift; Positions=132; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ATPase epsilon chain family. {ECO 0000305}. # SUBCELLULAR LOCATION ATPE_ECOLI Cell inner membrane {ECO 0000269|PubMed 16079137, ECO 0000269|PubMed 21778229}; Peripheral membrane protein {ECO 0000269|PubMed 16079137, ECO 0000269|PubMed 21778229}. # SUBUNIT ATPE_ECOLI F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits a, b and c. {ECO 0000269|PubMed 16079137}. # SUPFAM SSF46604 SSF46604 # SUPFAM SSF51344 SSF51344 # TCDB 3.A.2.1 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily # TIGRFAMs TIGR01216 ATP_synt_epsi # eggNOG COG0355 LUCA # eggNOG ENOG4105KNM Bacteria BLAST swissprot:ATPE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ATPE_ECOLI BioCyc ECOL316407:JW3709-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3709-MONOMER BioCyc EcoCyc:ATPC-MONOMER http://biocyc.org/getid?id=EcoCyc:ATPC-MONOMER BioCyc MetaCyc:ATPC-MONOMER http://biocyc.org/getid?id=MetaCyc:ATPC-MONOMER COG COG0355 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0355 DIP DIP-47828N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47828N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1016/0006-291X(82)90922-6 http://dx.doi.org/10.1016/0006-291X(82)90922-6 DOI 10.1016/S0969-2126(97)00272-4 http://dx.doi.org/10.1016/S0969-2126(97)00272-4 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb1195-961 http://dx.doi.org/10.1038/nsb1195-961 DOI 10.1042/bj2240799 http://dx.doi.org/10.1042/bj2240799 DOI 10.1074/jbc.273.41.26645 http://dx.doi.org/10.1074/jbc.273.41.26645 DOI 10.1074/jbc.M111.245696 http://dx.doi.org/10.1074/jbc.M111.245696 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1093/nar/9.20.5287 http://dx.doi.org/10.1093/nar/9.20.5287 DOI 10.1111/j.1574-6968.1998.tb13343.x http://dx.doi.org/10.1111/j.1574-6968.1998.tb13343.x DOI 10.1111/j.1749-6632.1982.tb25731.x http://dx.doi.org/10.1111/j.1749-6632.1982.tb25731.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01594 http://www.ebi.ac.uk/ena/data/view/J01594 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M25464 http://www.ebi.ac.uk/ena/data/view/M25464 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00267 http://www.ebi.ac.uk/ena/data/view/V00267 EMBL V00311 http://www.ebi.ac.uk/ena/data/view/V00311 EMBL X01631 http://www.ebi.ac.uk/ena/data/view/X01631 EchoBASE EB0098 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0098 EcoGene EG10100 http://www.ecogene.org/geneInfo.php?eg_id=EG10100 EnsemblBacteria AAC76754 http://www.ensemblgenomes.org/id/AAC76754 EnsemblBacteria AAC76754 http://www.ensemblgenomes.org/id/AAC76754 EnsemblBacteria BAE77557 http://www.ensemblgenomes.org/id/BAE77557 EnsemblBacteria BAE77557 http://www.ensemblgenomes.org/id/BAE77557 EnsemblBacteria BAE77557 http://www.ensemblgenomes.org/id/BAE77557 EnsemblBacteria b3731 http://www.ensemblgenomes.org/id/b3731 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0045260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045260 GO_component GO:0045261 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045261 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0046933 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046933 GO_process GO:0015986 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015986 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 2.60.15.10 http://www.cathdb.info/version/latest/superfamily/2.60.15.10 GeneID 948245 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948245 HAMAP MF_00530 http://hamap.expasy.org/unirule/MF_00530 HOGENOM HOG000216025 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000216025&db=HOGENOM6 InParanoid P0A6E6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6E6 IntAct P0A6E6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6E6* InterPro IPR001469 http://www.ebi.ac.uk/interpro/entry/IPR001469 InterPro IPR020546 http://www.ebi.ac.uk/interpro/entry/IPR020546 InterPro IPR020547 http://www.ebi.ac.uk/interpro/entry/IPR020547 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko00194 http://www.genome.jp/dbget-bin/www_bget?ko00194 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3709 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3709 KEGG_Gene eco:b3731 http://www.genome.jp/dbget-bin/www_bget?eco:b3731 KEGG_Orthology KO:K02114 http://www.genome.jp/dbget-bin/www_bget?KO:K02114 KEGG_Pathway ko00190 http://www.genome.jp/kegg-bin/show_pathway?ko00190 KEGG_Pathway ko00195 http://www.genome.jp/kegg-bin/show_pathway?ko00195 OMA MTVHCDI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MTVHCDI PANTHER PTHR13822 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13822 PDB 1AQT http://www.ebi.ac.uk/pdbe-srv/view/entry/1AQT PDB 1BSH http://www.ebi.ac.uk/pdbe-srv/view/entry/1BSH PDB 1BSN http://www.ebi.ac.uk/pdbe-srv/view/entry/1BSN PDB 1FS0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1FS0 PDB 1QO1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1QO1 PDB 3OAA http://www.ebi.ac.uk/pdbe-srv/view/entry/3OAA PDBsum 1AQT http://www.ebi.ac.uk/pdbsum/1AQT PDBsum 1BSH http://www.ebi.ac.uk/pdbsum/1BSH PDBsum 1BSN http://www.ebi.ac.uk/pdbsum/1BSN PDBsum 1FS0 http://www.ebi.ac.uk/pdbsum/1FS0 PDBsum 1QO1 http://www.ebi.ac.uk/pdbsum/1QO1 PDBsum 3OAA http://www.ebi.ac.uk/pdbsum/3OAA PSORT swissprot:ATPE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ATPE_ECOLI PSORT-B swissprot:ATPE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ATPE_ECOLI PSORT2 swissprot:ATPE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ATPE_ECOLI Pfam PF00401 http://pfam.xfam.org/family/PF00401 Pfam PF02823 http://pfam.xfam.org/family/PF02823 Phobius swissprot:ATPE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ATPE_ECOLI PhylomeDB P0A6E6 http://phylomedb.org/?seqid=P0A6E6 ProteinModelPortal P0A6E6 http://www.proteinmodelportal.org/query/uniprot/P0A6E6 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21778229 http://www.ncbi.nlm.nih.gov/pubmed/21778229 PubMed 6272217 http://www.ncbi.nlm.nih.gov/pubmed/6272217 PubMed 6285901 http://www.ncbi.nlm.nih.gov/pubmed/6285901 PubMed 6301339 http://www.ncbi.nlm.nih.gov/pubmed/6301339 PubMed 6395859 http://www.ncbi.nlm.nih.gov/pubmed/6395859 PubMed 7583669 http://www.ncbi.nlm.nih.gov/pubmed/7583669 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9331422 http://www.ncbi.nlm.nih.gov/pubmed/9331422 PubMed 9756905 http://www.ncbi.nlm.nih.gov/pubmed/9756905 PubMed 9868784 http://www.ncbi.nlm.nih.gov/pubmed/9868784 RefSeq NP_418187 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418187 RefSeq WP_001251965 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001251965 SMR P0A6E6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6E6 STRING 511145.b3731 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3731&targetmode=cogs STRING COG0355 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0355&targetmode=cogs SUPFAM SSF46604 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46604 SUPFAM SSF51344 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51344 SWISS-2DPAGE P0A6E6 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A6E6 TCDB 3.A.2.1 http://www.tcdb.org/search/result.php?tc=3.A.2.1 TIGRFAMs TIGR01216 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01216 UniProtKB ATPE_ECOLI http://www.uniprot.org/uniprot/ATPE_ECOLI UniProtKB-AC P0A6E6 http://www.uniprot.org/uniprot/P0A6E6 charge swissprot:ATPE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ATPE_ECOLI eggNOG COG0355 http://eggnogapi.embl.de/nog_data/html/tree/COG0355 eggNOG ENOG4105KNM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KNM epestfind swissprot:ATPE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ATPE_ECOLI garnier swissprot:ATPE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ATPE_ECOLI helixturnhelix swissprot:ATPE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ATPE_ECOLI hmoment swissprot:ATPE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ATPE_ECOLI iep swissprot:ATPE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ATPE_ECOLI inforesidue swissprot:ATPE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ATPE_ECOLI octanol swissprot:ATPE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ATPE_ECOLI pepcoil swissprot:ATPE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ATPE_ECOLI pepdigest swissprot:ATPE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ATPE_ECOLI pepinfo swissprot:ATPE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ATPE_ECOLI pepnet swissprot:ATPE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ATPE_ECOLI pepstats swissprot:ATPE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ATPE_ECOLI pepwheel swissprot:ATPE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ATPE_ECOLI pepwindow swissprot:ATPE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ATPE_ECOLI sigcleave swissprot:ATPE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ATPE_ECOLI ## Database ID URL or Descriptions # AltName HEMX_ECOLI ORF X # BioGrid 4259707 141 # CATALYTIC ACTIVITY HEMX_ECOLI S-adenosyl-L-methionine + precorrin-1 = S- adenosyl-L-homocysteine + precorrin-2. # CATALYTIC ACTIVITY HEMX_ECOLI S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L-homocysteine + precorrin-1. # EcoGene EG10433 hemX # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0004851 uroporphyrin-III C-methyltransferase activity; IEA:UniProtKB-EC. # GO_process GO:0006779 porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0009236 cobalamin biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # IntAct P09127 3 # InterPro IPR007470 HemX # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00860 Porphyrin and chlorophyll metabolism # Organism HEMX_ECOLI Escherichia coli (strain K12) # PATHWAY Cofactor biosynthesis; adenosylcobalamin biosynthesis; precorrin-2 from uroporphyrinogen III step 1/1. # PATRIC 32123105 VBIEscCol129921_3918 # PIR S02185 S02185 # Pfam PF04375 HemX # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HEMX_ECOLI Putative uroporphyrinogen-III C-methyltransferase # RefSeq NP_418247 NC_000913.3 # RefSeq WP_000138997 NZ_LN832404.1 # SUBCELLULAR LOCATION HEMX_ECOLI Cell inner membrane {ECO 0000269|PubMed 16079137}; Single-pass membrane protein {ECO 0000269|PubMed 16079137}. # SUBUNIT Homooligomer, possibly a homopentamer. {ECO:0000269|PubMed 16079137}. # UniPathway UPA00148 UER00211 # eggNOG COG2959 LUCA # eggNOG ENOG4105ECF Bacteria BLAST swissprot:HEMX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HEMX_ECOLI BioCyc ECOL316407:JW3775-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3775-MONOMER BioCyc EcoCyc:HEMX-MONOMER http://biocyc.org/getid?id=EcoCyc:HEMX-MONOMER BioCyc MetaCyc:HEMX-MONOMER http://biocyc.org/getid?id=MetaCyc:HEMX-MONOMER COG COG2959 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2959 DIP DIP-9888N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9888N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1093/nar/16.20.9871 http://dx.doi.org/10.1093/nar/16.20.9871 DOI 10.1093/nar/16.24.11835 http://dx.doi.org/10.1093/nar/16.24.11835 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.1.107 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.107 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X12614 http://www.ebi.ac.uk/ena/data/view/X12614 EMBL X13406 http://www.ebi.ac.uk/ena/data/view/X13406 ENZYME 2.1.1.107 http://enzyme.expasy.org/EC/2.1.1.107 EchoBASE EB0428 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0428 EcoGene EG10433 http://www.ecogene.org/geneInfo.php?eg_id=EG10433 EnsemblBacteria AAC76806 http://www.ensemblgenomes.org/id/AAC76806 EnsemblBacteria AAC76806 http://www.ensemblgenomes.org/id/AAC76806 EnsemblBacteria BAE77498 http://www.ensemblgenomes.org/id/BAE77498 EnsemblBacteria BAE77498 http://www.ensemblgenomes.org/id/BAE77498 EnsemblBacteria BAE77498 http://www.ensemblgenomes.org/id/BAE77498 EnsemblBacteria b3803 http://www.ensemblgenomes.org/id/b3803 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0004851 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004851 GO_process GO:0006779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006779 GO_process GO:0009236 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009236 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GeneID 948446 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948446 HOGENOM HOG000270899 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000270899&db=HOGENOM6 InParanoid P09127 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P09127 IntAct P09127 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P09127* IntEnz 2.1.1.107 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.107 InterPro IPR007470 http://www.ebi.ac.uk/interpro/entry/IPR007470 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3775 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3775 KEGG_Gene eco:b3803 http://www.genome.jp/dbget-bin/www_bget?eco:b3803 KEGG_Orthology KO:K02496 http://www.genome.jp/dbget-bin/www_bget?KO:K02496 KEGG_Pathway ko00860 http://www.genome.jp/kegg-bin/show_pathway?ko00860 KEGG_Reaction rn:R03194 http://www.genome.jp/dbget-bin/www_bget?rn:R03194 OMA SQQSITM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SQQSITM PSORT swissprot:HEMX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HEMX_ECOLI PSORT-B swissprot:HEMX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HEMX_ECOLI PSORT2 swissprot:HEMX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HEMX_ECOLI Pfam PF04375 http://pfam.xfam.org/family/PF04375 Phobius swissprot:HEMX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HEMX_ECOLI PhylomeDB P09127 http://phylomedb.org/?seqid=P09127 ProteinModelPortal P09127 http://www.proteinmodelportal.org/query/uniprot/P09127 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3054815 http://www.ncbi.nlm.nih.gov/pubmed/3054815 PubMed 3062586 http://www.ncbi.nlm.nih.gov/pubmed/3062586 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_418247 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418247 RefSeq WP_000138997 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000138997 STRING 511145.b3803 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3803&targetmode=cogs STRING COG2959 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2959&targetmode=cogs UniProtKB HEMX_ECOLI http://www.uniprot.org/uniprot/HEMX_ECOLI UniProtKB-AC P09127 http://www.uniprot.org/uniprot/P09127 charge swissprot:HEMX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HEMX_ECOLI eggNOG COG2959 http://eggnogapi.embl.de/nog_data/html/tree/COG2959 eggNOG ENOG4105ECF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ECF epestfind swissprot:HEMX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HEMX_ECOLI garnier swissprot:HEMX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HEMX_ECOLI helixturnhelix swissprot:HEMX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HEMX_ECOLI hmoment swissprot:HEMX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HEMX_ECOLI iep swissprot:HEMX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HEMX_ECOLI inforesidue swissprot:HEMX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HEMX_ECOLI octanol swissprot:HEMX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HEMX_ECOLI pepcoil swissprot:HEMX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HEMX_ECOLI pepdigest swissprot:HEMX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HEMX_ECOLI pepinfo swissprot:HEMX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HEMX_ECOLI pepnet swissprot:HEMX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HEMX_ECOLI pepstats swissprot:HEMX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HEMX_ECOLI pepwheel swissprot:HEMX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HEMX_ECOLI pepwindow swissprot:HEMX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HEMX_ECOLI sigcleave swissprot:HEMX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HEMX_ECOLI ## Database ID URL or Descriptions # BioGrid 4262290 25 # EcoGene EG13122 ygcO # FUNCTION YGCO_ECOLI Could be a 3Fe-4S cluster-containing protein. Probably participates in a redox process with YgcN, YgcQ and YgcR. # GO_function GO:0005506 iron ion binding; IEA:InterPro. # GO_function GO:0051536 iron-sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0009294 DNA mediated transformation; IMP:EcoCyc. # GO_process GO:0055114 oxidation-reduction process; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # IntAct Q46905 4 # InterPro IPR012206 Fd_FixX # InterPro IPR017896 4Fe4S_Fe-S-bd # Organism YGCO_ECOLI Escherichia coli (strain K12) # PATRIC 32120946 VBIEscCol129921_2865 # PIR C65058 C65058 # PIRSF PIRSF036548 Fdx_FixX # PROSITE PS51379 4FE4S_FER_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGCO_ECOLI Ferredoxin-like protein YgcO # RefSeq NP_417247 NC_000913.3 # RefSeq WP_000109529 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA69277.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the bacterial-type ferredoxin family. FixX subfamily. {ECO 0000305}. # SIMILARITY Contains 1 4Fe-4S ferredoxin-type domain. {ECO:0000255|PROSITE-ProRule PRU00711}. # eggNOG COG2440 LUCA # eggNOG ENOG4105WQV Bacteria BLAST swissprot:YGCO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGCO_ECOLI BioCyc ECOL316407:JW2737-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2737-MONOMER BioCyc EcoCyc:G7433-MONOMER http://biocyc.org/getid?id=EcoCyc:G7433-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EchoBASE EB2923 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2923 EcoGene EG13122 http://www.ecogene.org/geneInfo.php?eg_id=EG13122 EnsemblBacteria AAC75809 http://www.ensemblgenomes.org/id/AAC75809 EnsemblBacteria AAC75809 http://www.ensemblgenomes.org/id/AAC75809 EnsemblBacteria BAE76844 http://www.ensemblgenomes.org/id/BAE76844 EnsemblBacteria BAE76844 http://www.ensemblgenomes.org/id/BAE76844 EnsemblBacteria BAE76844 http://www.ensemblgenomes.org/id/BAE76844 EnsemblBacteria b2767 http://www.ensemblgenomes.org/id/b2767 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0051536 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051536 GO_process GO:0009294 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009294 GO_process GO:0055114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 945120 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945120 HOGENOM HOG000018925 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000018925&db=HOGENOM6 InParanoid Q46905 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46905 IntAct Q46905 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46905* InterPro IPR012206 http://www.ebi.ac.uk/interpro/entry/IPR012206 InterPro IPR017896 http://www.ebi.ac.uk/interpro/entry/IPR017896 KEGG_Gene ecj:JW2737 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2737 KEGG_Gene eco:b2767 http://www.genome.jp/dbget-bin/www_bget?eco:b2767 OMA WLINACP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WLINACP PROSITE PS51379 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51379 PSORT swissprot:YGCO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGCO_ECOLI PSORT-B swissprot:YGCO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGCO_ECOLI PSORT2 swissprot:YGCO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGCO_ECOLI Phobius swissprot:YGCO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGCO_ECOLI PhylomeDB Q46905 http://phylomedb.org/?seqid=Q46905 ProteinModelPortal Q46905 http://www.proteinmodelportal.org/query/uniprot/Q46905 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417247 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417247 RefSeq WP_000109529 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000109529 STRING 511145.b2767 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2767&targetmode=cogs UniProtKB YGCO_ECOLI http://www.uniprot.org/uniprot/YGCO_ECOLI UniProtKB-AC Q46905 http://www.uniprot.org/uniprot/Q46905 charge swissprot:YGCO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGCO_ECOLI eggNOG COG2440 http://eggnogapi.embl.de/nog_data/html/tree/COG2440 eggNOG ENOG4105WQV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105WQV epestfind swissprot:YGCO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGCO_ECOLI garnier swissprot:YGCO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGCO_ECOLI helixturnhelix swissprot:YGCO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGCO_ECOLI hmoment swissprot:YGCO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGCO_ECOLI iep swissprot:YGCO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGCO_ECOLI inforesidue swissprot:YGCO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGCO_ECOLI octanol swissprot:YGCO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGCO_ECOLI pepcoil swissprot:YGCO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGCO_ECOLI pepdigest swissprot:YGCO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGCO_ECOLI pepinfo swissprot:YGCO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGCO_ECOLI pepnet swissprot:YGCO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGCO_ECOLI pepstats swissprot:YGCO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGCO_ECOLI pepwheel swissprot:YGCO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGCO_ECOLI pepwindow swissprot:YGCO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGCO_ECOLI sigcleave swissprot:YGCO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGCO_ECOLI ## Database ID URL or Descriptions # BioGrid 4261449 276 # COFACTOR Name=Ca(2+); Xref=ChEBI:CHEBI 29108; Note=Binds 2 calcium ions per monomer.; # COFACTOR Name=pyrroloquinoline quinone; Xref=ChEBI:CHEBI 58442; # EcoGene EG13480 yliI # FUNCTION YLII_ECOLI Aldose sugar dehydrogenase with broad substrate specificity. The physiological substrate is unknown. Can oxidize glucose to gluconolactone. Can also utilize D-arabinose, L- arabinose and 2-deoxy-glucose. Has higher activity towards oligomeric sugars, such as maltose, maltotriose or cellobiose. It may function to input sugar-derived electrons into the respiratory network. {ECO 0000269|PubMed 16864586}. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0005509 calcium ion binding; IDA:EcoCyc. # GO_function GO:0016901 oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor; IDA:EcoCyc. # GO_function GO:0070968 pyrroloquinoline quinone binding; IDA:EcoCyc. # GO_process GO:0005975 carbohydrate metabolic process; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # Gene3D 2.120.10.30 -; 1. # IntAct P75804 2 # InterPro IPR011041 Quinoprot_gluc/sorb_DH # InterPro IPR011042 6-blade_b-propeller_TolB-like # InterPro IPR012938 Glc/Sorbosone_DH # Organism YLII_ECOLI Escherichia coli (strain K12) # PATRIC 32116877 VBIEscCol129921_0864 # PDB 2G8S X-ray; 1.50 A; A/B=21-370 # PIR E64821 E64821 # Pfam PF07995 GSDH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YLII_ECOLI Soluble aldose sugar dehydrogenase YliI # RefSeq NP_415358 NC_000913.3 # RefSeq WP_000555031 NZ_LN832404.1 # SIMILARITY Belongs to the PQQ oxidoreductase GdhB family. {ECO 0000305}. # SUBUNIT Monomer. {ECO:0000269|PubMed 16864586}. # SUPFAM SSF50952 SSF50952 # eggNOG COG2133 LUCA # eggNOG ENOG4105D8V Bacteria BLAST swissprot:YLII_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YLII_ECOLI BioCyc ECOL316407:JW0821-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0821-MONOMER BioCyc EcoCyc:G6437-MONOMER http://biocyc.org/getid?id=EcoCyc:G6437-MONOMER BioCyc MetaCyc:G6437-MONOMER http://biocyc.org/getid?id=MetaCyc:G6437-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M601783200 http://dx.doi.org/10.1074/jbc.M601783200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.5.- http://www.genome.jp/dbget-bin/www_bget?EC:1.1.5.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.1.5.- http://enzyme.expasy.org/EC/1.1.5.- EchoBASE EB3253 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3253 EcoGene EG13480 http://www.ecogene.org/geneInfo.php?eg_id=EG13480 EnsemblBacteria AAC73924 http://www.ensemblgenomes.org/id/AAC73924 EnsemblBacteria AAC73924 http://www.ensemblgenomes.org/id/AAC73924 EnsemblBacteria BAA35540 http://www.ensemblgenomes.org/id/BAA35540 EnsemblBacteria BAA35540 http://www.ensemblgenomes.org/id/BAA35540 EnsemblBacteria BAA35540 http://www.ensemblgenomes.org/id/BAA35540 EnsemblBacteria b0837 http://www.ensemblgenomes.org/id/b0837 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0005509 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509 GO_function GO:0016901 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016901 GO_function GO:0070968 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070968 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 Gene3D 2.120.10.30 http://www.cathdb.info/version/latest/superfamily/2.120.10.30 GeneID 945467 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945467 HOGENOM HOG000246901 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000246901&db=HOGENOM6 InParanoid P75804 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75804 IntAct P75804 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75804* IntEnz 1.1.5 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.5 InterPro IPR011041 http://www.ebi.ac.uk/interpro/entry/IPR011041 InterPro IPR011042 http://www.ebi.ac.uk/interpro/entry/IPR011042 InterPro IPR012938 http://www.ebi.ac.uk/interpro/entry/IPR012938 KEGG_Gene ecj:JW0821 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0821 KEGG_Gene eco:b0837 http://www.genome.jp/dbget-bin/www_bget?eco:b0837 OMA TIYLCYA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TIYLCYA PDB 2G8S http://www.ebi.ac.uk/pdbe-srv/view/entry/2G8S PDBsum 2G8S http://www.ebi.ac.uk/pdbsum/2G8S PSORT swissprot:YLII_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YLII_ECOLI PSORT-B swissprot:YLII_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YLII_ECOLI PSORT2 swissprot:YLII_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YLII_ECOLI Pfam PF07995 http://pfam.xfam.org/family/PF07995 Phobius swissprot:YLII_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YLII_ECOLI PhylomeDB P75804 http://phylomedb.org/?seqid=P75804 ProteinModelPortal P75804 http://www.proteinmodelportal.org/query/uniprot/P75804 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16864586 http://www.ncbi.nlm.nih.gov/pubmed/16864586 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415358 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415358 RefSeq WP_000555031 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000555031 SMR P75804 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75804 STRING 511145.b0837 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0837&targetmode=cogs SUPFAM SSF50952 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50952 UniProtKB YLII_ECOLI http://www.uniprot.org/uniprot/YLII_ECOLI UniProtKB-AC P75804 http://www.uniprot.org/uniprot/P75804 charge swissprot:YLII_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YLII_ECOLI eggNOG COG2133 http://eggnogapi.embl.de/nog_data/html/tree/COG2133 eggNOG ENOG4105D8V http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D8V epestfind swissprot:YLII_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YLII_ECOLI garnier swissprot:YLII_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YLII_ECOLI helixturnhelix swissprot:YLII_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YLII_ECOLI hmoment swissprot:YLII_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YLII_ECOLI iep swissprot:YLII_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YLII_ECOLI inforesidue swissprot:YLII_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YLII_ECOLI octanol swissprot:YLII_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YLII_ECOLI pepcoil swissprot:YLII_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YLII_ECOLI pepdigest swissprot:YLII_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YLII_ECOLI pepinfo swissprot:YLII_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YLII_ECOLI pepnet swissprot:YLII_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YLII_ECOLI pepstats swissprot:YLII_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YLII_ECOLI pepwheel swissprot:YLII_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YLII_ECOLI pepwindow swissprot:YLII_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YLII_ECOLI sigcleave swissprot:YLII_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YLII_ECOLI ## Database ID URL or Descriptions # AltName Cation transport regulatory protein ChaC {ECO 0000305|Ref.1} # BioGrid 4261606 11 # CATALYTIC ACTIVITY Glutathione = 5-oxoproline + cysteinylglycine. {ECO:0000250|UniProtKB P32656}. # CDD cd06661 GGCT_like # EcoGene EG12403 chaC # FUNCTION CHAC_ECOLI Catalyzes the cleavage glutathione into 5-oxoproline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. {ECO 0000250|UniProtKB P32656}. # GO_function GO:0003839 gamma-glutamylcyclotransferase activity; IEA:InterPro. # GO_process GO:0006751 glutathione catabolic process; IEA:InterPro. # GO_process GO:0071973 bacterial-type flagellum-dependent cell motility; IMP:EcoCyc. # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0048870 cell motility # Gene3D 3.10.490.10 -; 1. # IntAct P39163 2 # InterPro IPR006840 ChaC # InterPro IPR013024 GGCT-like # Organism CHAC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR12192 PTHR12192 # PATRIC 32117694 VBIEscCol129921_1269 # PIR G64868 G64868 # Pfam PF04752 ChaC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Glutathione-specific gamma-glutamylcyclotransferase {ECO:0000250|UniProtKB P32656} # RefSeq NP_415736 NC_000913.3 # RefSeq WP_001336325 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA20198.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA36076.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily. {ECO 0000305}. # SUPFAM SSF110857 SSF110857 # eggNOG COG3703 LUCA # eggNOG ENOG4108NH8 Bacteria BLAST swissprot:CHAC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CHAC_ECOLI BioCyc ECOL316407:JW1209-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1209-MONOMER BioCyc EcoCyc:EG12403-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12403-MONOMER COG COG3703 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3703 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.2.- {ECO:0000250|UniProtKB:P32656} http://www.genome.jp/dbget-bin/www_bget?EC:2.3.2.- {ECO:0000250|UniProtKB:P32656} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L28709 http://www.ebi.ac.uk/ena/data/view/L28709 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.3.2.- {ECO:0000250|UniProtKB:P32656} http://enzyme.expasy.org/EC/2.3.2.- {ECO:0000250|UniProtKB:P32656} EchoBASE EB2303 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2303 EcoGene EG12403 http://www.ecogene.org/geneInfo.php?eg_id=EG12403 EnsemblBacteria AAC74302 http://www.ensemblgenomes.org/id/AAC74302 EnsemblBacteria AAC74302 http://www.ensemblgenomes.org/id/AAC74302 EnsemblBacteria BAA36076 http://www.ensemblgenomes.org/id/BAA36076 EnsemblBacteria BAA36076 http://www.ensemblgenomes.org/id/BAA36076 EnsemblBacteria BAA36076 http://www.ensemblgenomes.org/id/BAA36076 EnsemblBacteria b1218 http://www.ensemblgenomes.org/id/b1218 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003839 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003839 GO_process GO:0006751 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006751 GO_process GO:0071973 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071973 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 Gene3D 3.10.490.10 http://www.cathdb.info/version/latest/superfamily/3.10.490.10 GeneID 945793 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945793 HOGENOM HOG000264265 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000264265&db=HOGENOM6 InParanoid P39163 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39163 IntAct P39163 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39163* IntEnz 2.3.2.- {ECO:0000250|UniProtKB:P32656} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.2.- {ECO:0000250|UniProtKB:P32656} InterPro IPR006840 http://www.ebi.ac.uk/interpro/entry/IPR006840 InterPro IPR013024 http://www.ebi.ac.uk/interpro/entry/IPR013024 KEGG_Gene ecj:JW1209 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1209 KEGG_Gene eco:b1218 http://www.genome.jp/dbget-bin/www_bget?eco:b1218 KEGG_Orthology KO:K07232 http://www.genome.jp/dbget-bin/www_bget?KO:K07232 OMA WNPALEY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WNPALEY PANTHER PTHR12192 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12192 PSORT swissprot:CHAC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CHAC_ECOLI PSORT-B swissprot:CHAC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CHAC_ECOLI PSORT2 swissprot:CHAC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CHAC_ECOLI Pfam PF04752 http://pfam.xfam.org/family/PF04752 Phobius swissprot:CHAC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CHAC_ECOLI PhylomeDB P39163 http://phylomedb.org/?seqid=P39163 ProteinModelPortal P39163 http://www.proteinmodelportal.org/query/uniprot/P39163 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415736 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415736 RefSeq WP_001336325 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001336325 STRING 511145.b1218 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1218&targetmode=cogs STRING COG3703 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3703&targetmode=cogs SUPFAM SSF110857 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF110857 UniProtKB CHAC_ECOLI http://www.uniprot.org/uniprot/CHAC_ECOLI UniProtKB-AC P39163 http://www.uniprot.org/uniprot/P39163 charge swissprot:CHAC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CHAC_ECOLI eggNOG COG3703 http://eggnogapi.embl.de/nog_data/html/tree/COG3703 eggNOG ENOG4108NH8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108NH8 epestfind swissprot:CHAC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CHAC_ECOLI garnier swissprot:CHAC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CHAC_ECOLI helixturnhelix swissprot:CHAC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CHAC_ECOLI hmoment swissprot:CHAC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CHAC_ECOLI iep swissprot:CHAC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CHAC_ECOLI inforesidue swissprot:CHAC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CHAC_ECOLI octanol swissprot:CHAC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CHAC_ECOLI pepcoil swissprot:CHAC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CHAC_ECOLI pepdigest swissprot:CHAC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CHAC_ECOLI pepinfo swissprot:CHAC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CHAC_ECOLI pepnet swissprot:CHAC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CHAC_ECOLI pepstats swissprot:CHAC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CHAC_ECOLI pepwheel swissprot:CHAC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CHAC_ECOLI pepwindow swissprot:CHAC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CHAC_ECOLI sigcleave swissprot:CHAC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CHAC_ECOLI ## Database ID URL or Descriptions # BioGrid 4260896 257 # EcoGene EG14376 ypdI # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_process GO:0009242 colanic acid biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # Organism YPDI_ECOLI Escherichia coli (strain K12) # PIR E65011 E65011 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YPDI_ECOLI Uncharacterized lipoprotein YpdI # RefSeq NP_416877 NC_000913.3 # RefSeq WP_000867631 NZ_LN832404.1 # SUBCELLULAR LOCATION YPDI_ECOLI Cell membrane {ECO 0000305}; Lipid-anchor {ECO 0000305}. BLAST swissprot:YPDI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YPDI_ECOLI BioCyc ECOL316407:JW2373-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2373-MONOMER BioCyc EcoCyc:G7239-MONOMER http://biocyc.org/getid?id=EcoCyc:G7239-MONOMER DIP DIP-12820N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12820N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4119 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4119 EcoGene EG14376 http://www.ecogene.org/geneInfo.php?eg_id=EG14376 EnsemblBacteria AAC75435 http://www.ensemblgenomes.org/id/AAC75435 EnsemblBacteria AAC75435 http://www.ensemblgenomes.org/id/AAC75435 EnsemblBacteria BAE76706 http://www.ensemblgenomes.org/id/BAE76706 EnsemblBacteria BAE76706 http://www.ensemblgenomes.org/id/BAE76706 EnsemblBacteria BAE76706 http://www.ensemblgenomes.org/id/BAE76706 EnsemblBacteria b2376 http://www.ensemblgenomes.org/id/b2376 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_process GO:0009242 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009242 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 949107 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949107 HOGENOM HOG000122912 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122912&db=HOGENOM6 IntAct O32528 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O32528* KEGG_Gene ecj:JW2373 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2373 KEGG_Gene eco:b2376 http://www.genome.jp/dbget-bin/www_bget?eco:b2376 OMA STKANYL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=STKANYL PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YPDI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YPDI_ECOLI PSORT-B swissprot:YPDI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YPDI_ECOLI PSORT2 swissprot:YPDI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YPDI_ECOLI Phobius swissprot:YPDI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YPDI_ECOLI ProteinModelPortal O32528 http://www.proteinmodelportal.org/query/uniprot/O32528 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416877 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416877 RefSeq WP_000867631 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000867631 STRING 511145.b2376 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2376&targetmode=cogs UniProtKB YPDI_ECOLI http://www.uniprot.org/uniprot/YPDI_ECOLI UniProtKB-AC O32528 http://www.uniprot.org/uniprot/O32528 charge swissprot:YPDI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YPDI_ECOLI epestfind swissprot:YPDI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YPDI_ECOLI garnier swissprot:YPDI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YPDI_ECOLI helixturnhelix swissprot:YPDI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YPDI_ECOLI hmoment swissprot:YPDI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YPDI_ECOLI iep swissprot:YPDI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YPDI_ECOLI inforesidue swissprot:YPDI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YPDI_ECOLI octanol swissprot:YPDI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YPDI_ECOLI pepcoil swissprot:YPDI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YPDI_ECOLI pepdigest swissprot:YPDI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YPDI_ECOLI pepinfo swissprot:YPDI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YPDI_ECOLI pepnet swissprot:YPDI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YPDI_ECOLI pepstats swissprot:YPDI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YPDI_ECOLI pepwheel swissprot:YPDI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YPDI_ECOLI pepwindow swissprot:YPDI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YPDI_ECOLI sigcleave swissprot:YPDI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YPDI_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES YFCF_ECOLI Kinetic parameters KM=0.24 mM for glutathione {ECO 0000269|PubMed 17018556}; KM=1.1 mM for 1-chloro-2,4-dinitrobenzene {ECO 0000269|PubMed 17018556}; Note=kcat is 0.11 sec(-1) for the GSH transferase reaction with CDNB as substrate.; pH dependence Activity decreases as pH is lowered from neutral to acidic. {ECO 0000269|PubMed 17018556}; # BioGrid 4260516 12 # CATALYTIC ACTIVITY RX + glutathione = HX + R-S-glutathione. {ECO:0000269|PubMed 17018556}. # DISRUPTION PHENOTYPE Deletion of yfcF decreases the resistance of the bacteria to hydrogen peroxide. {ECO:0000269|PubMed 17018556}. # ENZYME REGULATION GSH transferase activity is inhibited by S- hexyl glutathione. {ECO:0000269|PubMed 17018556}. # EcoGene EG14109 yfcF # FUNCTION YFCF_ECOLI Exhibits glutathione (GSH) S-transferase activity toward 1-chloro-2,4-dinitrobenzene (CDNB); however this activity is as low as 1% of that of GstA. Also displays a GSH-dependent peroxidase activity toward cumene hydroperoxide. Is involved in defense against oxidative stress, probably via its peroxidase activity. {ECO 0000269|PubMed 17018556}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0004364 glutathione transferase activity; IDA:EcoCyc. # GO_function GO:0004601 peroxidase activity; IEA:UniProtKB-KW. # GO_process GO:0006749 glutathione metabolic process; IBA:GO_Central. # GO_process GO:0042542 response to hydrogen peroxide; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.20.1050.10 -; 1. # Gene3D 3.40.30.10 -; 1. # IntAct P77544 3 # InterPro IPR004045 Glutathione_S-Trfase_N # InterPro IPR010987 Glutathione-S-Trfase_C-like # InterPro IPR012336 Thioredoxin-like_fold # Organism YFCF_ECOLI Escherichia coli (strain K12) # PATRIC 32119973 VBIEscCol129921_2396 # PDB 3BBY X-ray; 1.85 A; A=1-214 # PIR C65002 C65002 # PROSITE PS50404 GST_NTER # PROSITE PS50405 GST_CTER # Pfam PF13417 GST_N_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFCF_ECOLI Glutathione S-transferase YfcF # RefSeq NP_416804 NC_000913.3 # RefSeq WP_000042442 NZ_LN832404.1 # SIMILARITY Belongs to the GST superfamily. {ECO 0000305}. # SIMILARITY Contains 1 GST C-terminal domain. {ECO 0000305}. # SIMILARITY Contains 1 GST N-terminal domain. {ECO 0000305}. # SUPFAM SSF47616 SSF47616 # SUPFAM SSF52833 SSF52833 # eggNOG COG0625 LUCA # eggNOG ENOG4108SHQ Bacteria BLAST swissprot:YFCF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFCF_ECOLI BioCyc ECOL316407:JW2298-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2298-MONOMER BioCyc EcoCyc:G7193-MONOMER http://biocyc.org/getid?id=EcoCyc:G7193-MONOMER BioCyc MetaCyc:G7193-MONOMER http://biocyc.org/getid?id=MetaCyc:G7193-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/jb/mvj199 http://dx.doi.org/10.1093/jb/mvj199 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.5.1.18 http://www.genome.jp/dbget-bin/www_bget?EC:2.5.1.18 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.5.1.18 http://enzyme.expasy.org/EC/2.5.1.18 EchoBASE EB3862 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3862 EcoGene EG14109 http://www.ecogene.org/geneInfo.php?eg_id=EG14109 EnsemblBacteria AAC75361 http://www.ensemblgenomes.org/id/AAC75361 EnsemblBacteria AAC75361 http://www.ensemblgenomes.org/id/AAC75361 EnsemblBacteria BAA16138 http://www.ensemblgenomes.org/id/BAA16138 EnsemblBacteria BAA16138 http://www.ensemblgenomes.org/id/BAA16138 EnsemblBacteria BAA16138 http://www.ensemblgenomes.org/id/BAA16138 EnsemblBacteria b2301 http://www.ensemblgenomes.org/id/b2301 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004364 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004364 GO_function GO:0004601 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004601 GO_process GO:0006749 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006749 GO_process GO:0042542 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042542 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016765 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.20.1050.10 http://www.cathdb.info/version/latest/superfamily/1.20.1050.10 Gene3D 3.40.30.10 http://www.cathdb.info/version/latest/superfamily/3.40.30.10 GeneID 946749 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946749 HOGENOM HOG000255229 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000255229&db=HOGENOM6 InParanoid P77544 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77544 IntAct P77544 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77544* IntEnz 2.5.1.18 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.5.1.18 InterPro IPR004045 http://www.ebi.ac.uk/interpro/entry/IPR004045 InterPro IPR010987 http://www.ebi.ac.uk/interpro/entry/IPR010987 InterPro IPR012336 http://www.ebi.ac.uk/interpro/entry/IPR012336 KEGG_Gene ecj:JW2298 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2298 KEGG_Gene eco:b2301 http://www.genome.jp/dbget-bin/www_bget?eco:b2301 OMA FSPYVMS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FSPYVMS PDB 3BBY http://www.ebi.ac.uk/pdbe-srv/view/entry/3BBY PDBsum 3BBY http://www.ebi.ac.uk/pdbsum/3BBY PROSITE PS50404 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50404 PROSITE PS50405 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50405 PSORT swissprot:YFCF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFCF_ECOLI PSORT-B swissprot:YFCF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFCF_ECOLI PSORT2 swissprot:YFCF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFCF_ECOLI Pfam PF13417 http://pfam.xfam.org/family/PF13417 Phobius swissprot:YFCF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFCF_ECOLI PhylomeDB P77544 http://phylomedb.org/?seqid=P77544 ProteinModelPortal P77544 http://www.proteinmodelportal.org/query/uniprot/P77544 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17018556 http://www.ncbi.nlm.nih.gov/pubmed/17018556 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416804 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416804 RefSeq WP_000042442 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000042442 SMR P77544 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77544 STRING 511145.b2301 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2301&targetmode=cogs SUPFAM SSF47616 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47616 SUPFAM SSF52833 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52833 UniProtKB YFCF_ECOLI http://www.uniprot.org/uniprot/YFCF_ECOLI UniProtKB-AC P77544 http://www.uniprot.org/uniprot/P77544 charge swissprot:YFCF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFCF_ECOLI eggNOG COG0625 http://eggnogapi.embl.de/nog_data/html/tree/COG0625 eggNOG ENOG4108SHQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108SHQ epestfind swissprot:YFCF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFCF_ECOLI garnier swissprot:YFCF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFCF_ECOLI helixturnhelix swissprot:YFCF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFCF_ECOLI hmoment swissprot:YFCF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFCF_ECOLI iep swissprot:YFCF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFCF_ECOLI inforesidue swissprot:YFCF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFCF_ECOLI octanol swissprot:YFCF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFCF_ECOLI pepcoil swissprot:YFCF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFCF_ECOLI pepdigest swissprot:YFCF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFCF_ECOLI pepinfo swissprot:YFCF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFCF_ECOLI pepnet swissprot:YFCF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFCF_ECOLI pepstats swissprot:YFCF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFCF_ECOLI pepwheel swissprot:YFCF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFCF_ECOLI pepwindow swissprot:YFCF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFCF_ECOLI sigcleave swissprot:YFCF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFCF_ECOLI ## Database ID URL or Descriptions # BioGrid 4260586 7 # EcoGene EG14203 yfgG # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # InterPro IPR022576 DUF2633 # Organism YFGG_ECOLI Escherichia coli (strain K12) # PATRIC 32120399 VBIEscCol129921_2602 # PIR G65026 G65026 # Pfam PF11119 DUF2633 # ProDom PD053432 PD053432 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFGG_ECOLI Uncharacterized protein YfgG # RefSeq NP_416999 NC_000913.3 # RefSeq WP_000076001 NZ_LN832404.1 # SUBCELLULAR LOCATION YFGG_ECOLI Membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. # TCDB 9.B.209.1 the duf2633 (duf2633) family # eggNOG ENOG41062G3 Bacteria # eggNOG ENOG4112AVR LUCA BLAST swissprot:YFGG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFGG_ECOLI BioCyc ECOL316407:JW5399-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5399-MONOMER BioCyc EcoCyc:G7315-MONOMER http://biocyc.org/getid?id=EcoCyc:G7315-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3955 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3955 EcoGene EG14203 http://www.ecogene.org/geneInfo.php?eg_id=EG14203 EnsemblBacteria AAC75557 http://www.ensemblgenomes.org/id/AAC75557 EnsemblBacteria AAC75557 http://www.ensemblgenomes.org/id/AAC75557 EnsemblBacteria BAE76725 http://www.ensemblgenomes.org/id/BAE76725 EnsemblBacteria BAE76725 http://www.ensemblgenomes.org/id/BAE76725 EnsemblBacteria BAE76725 http://www.ensemblgenomes.org/id/BAE76725 EnsemblBacteria b2504 http://www.ensemblgenomes.org/id/b2504 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GeneID 946980 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946980 HOGENOM HOG000219244 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219244&db=HOGENOM6 InterPro IPR022576 http://www.ebi.ac.uk/interpro/entry/IPR022576 KEGG_Gene ecj:JW5399 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5399 KEGG_Gene eco:b2504 http://www.genome.jp/dbget-bin/www_bget?eco:b2504 OMA HQDKKAS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HQDKKAS PSORT swissprot:YFGG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFGG_ECOLI PSORT-B swissprot:YFGG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFGG_ECOLI PSORT2 swissprot:YFGG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFGG_ECOLI Pfam PF11119 http://pfam.xfam.org/family/PF11119 Phobius swissprot:YFGG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFGG_ECOLI ProteinModelPortal P64545 http://www.proteinmodelportal.org/query/uniprot/P64545 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416999 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416999 RefSeq WP_000076001 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000076001 STRING 511145.b2504 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2504&targetmode=cogs TCDB 9.B.209.1 http://www.tcdb.org/search/result.php?tc=9.B.209.1 UniProtKB YFGG_ECOLI http://www.uniprot.org/uniprot/YFGG_ECOLI UniProtKB-AC P64545 http://www.uniprot.org/uniprot/P64545 charge swissprot:YFGG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFGG_ECOLI eggNOG ENOG41062G3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41062G3 eggNOG ENOG4112AVR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4112AVR epestfind swissprot:YFGG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFGG_ECOLI garnier swissprot:YFGG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFGG_ECOLI helixturnhelix swissprot:YFGG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFGG_ECOLI hmoment swissprot:YFGG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFGG_ECOLI iep swissprot:YFGG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFGG_ECOLI inforesidue swissprot:YFGG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFGG_ECOLI octanol swissprot:YFGG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFGG_ECOLI pepcoil swissprot:YFGG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFGG_ECOLI pepdigest swissprot:YFGG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFGG_ECOLI pepinfo swissprot:YFGG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFGG_ECOLI pepnet swissprot:YFGG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFGG_ECOLI pepstats swissprot:YFGG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFGG_ECOLI pepwheel swissprot:YFGG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFGG_ECOLI pepwindow swissprot:YFGG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFGG_ECOLI sigcleave swissprot:YFGG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFGG_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES ADEQ_ECOLI Kinetic parameters KM=6.5 uM for adenine {ECO 0000269|PubMed 24214977}; Vmax=11.0 nmol/min/mg enzyme {ECO 0000269|PubMed 24214977}; # BioGrid 4260893 111 # EcoGene EG11691 adeQ # FUNCTION ADEQ_ECOLI High-affinity transporter for adenine. {ECO 0000269|PubMed 24214977}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_function GO:0015207 adenine transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0015853 adenine transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR006043 Xant/urac/vitC # InterPro IPR026033 Pur_Permease_PbuG-like # InterPro IPR029940 AzgA # KEGG_Brite ko02000 Transporters # Organism ADEQ_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11119 PTHR11119 # PANTHER PTHR11119:SF9 PTHR11119:SF9 # PATRIC 32122821 VBIEscCol129921_3786 # PIR A65168 A65168 # PIRSF PIRSF005353 PbuG # Pfam PF00860 Xan_ur_permease # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ADEQ_ECOLI Adenine permease AdeQ # RefSeq NP_418120 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA62016.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the xanthine/uracil permease family. AzgA purine transporter (TC 2.A.1.40) subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION ADEQ_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 24214977}; Multi- pass membrane protein {ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 24214977}. # TCDB 2.A.40.7:the nucleobase/ascorbate transporter (nat) or nucleobase cation symporter-2 (ncs2) family # eggNOG COG2252 LUCA # eggNOG ENOG4105C7N Bacteria BLAST swissprot:ADEQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ADEQ_ECOLI BioCyc ECOL316407:JW5636-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5636-MONOMER BioCyc EcoCyc:EG11691-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11691-MONOMER BioCyc MetaCyc:EG11691-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11691-MONOMER COG COG2252 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2252 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M113.523340 http://dx.doi.org/10.1074/jbc.M113.523340 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1642 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1642 EcoGene EG11691 http://www.ecogene.org/geneInfo.php?eg_id=EG11691 EnsemblBacteria AAC76687 http://www.ensemblgenomes.org/id/AAC76687 EnsemblBacteria AAC76687 http://www.ensemblgenomes.org/id/AAC76687 EnsemblBacteria BAE77629 http://www.ensemblgenomes.org/id/BAE77629 EnsemblBacteria BAE77629 http://www.ensemblgenomes.org/id/BAE77629 EnsemblBacteria BAE77629 http://www.ensemblgenomes.org/id/BAE77629 EnsemblBacteria b3664 http://www.ensemblgenomes.org/id/b3664 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015207 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015207 GO_process GO:0015853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015853 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948174 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948174 HOGENOM HOG000244363 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000244363&db=HOGENOM6 InParanoid P31440 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31440 InterPro IPR006043 http://www.ebi.ac.uk/interpro/entry/IPR006043 InterPro IPR026033 http://www.ebi.ac.uk/interpro/entry/IPR026033 InterPro IPR029940 http://www.ebi.ac.uk/interpro/entry/IPR029940 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5636 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5636 KEGG_Gene eco:b3664 http://www.genome.jp/dbget-bin/www_bget?eco:b3664 KEGG_Orthology KO:K06901 http://www.genome.jp/dbget-bin/www_bget?KO:K06901 OMA WMALFAN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WMALFAN PANTHER PTHR11119 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11119 PANTHER PTHR11119:SF9 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11119:SF9 PSORT swissprot:ADEQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ADEQ_ECOLI PSORT-B swissprot:ADEQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ADEQ_ECOLI PSORT2 swissprot:ADEQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ADEQ_ECOLI Pfam PF00860 http://pfam.xfam.org/family/PF00860 Phobius swissprot:ADEQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ADEQ_ECOLI PhylomeDB P31440 http://phylomedb.org/?seqid=P31440 ProteinModelPortal P31440 http://www.proteinmodelportal.org/query/uniprot/P31440 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 24214977 http://www.ncbi.nlm.nih.gov/pubmed/24214977 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418120 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418120 STRING 511145.b3664 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3664&targetmode=cogs STRING COG2252 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2252&targetmode=cogs TCDB 2.A.40.7 http://www.tcdb.org/search/result.php?tc=2.A.40.7 UniProtKB ADEQ_ECOLI http://www.uniprot.org/uniprot/ADEQ_ECOLI UniProtKB-AC P31440 http://www.uniprot.org/uniprot/P31440 charge swissprot:ADEQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ADEQ_ECOLI eggNOG COG2252 http://eggnogapi.embl.de/nog_data/html/tree/COG2252 eggNOG ENOG4105C7N http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C7N epestfind swissprot:ADEQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ADEQ_ECOLI garnier swissprot:ADEQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ADEQ_ECOLI helixturnhelix swissprot:ADEQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ADEQ_ECOLI hmoment swissprot:ADEQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ADEQ_ECOLI iep swissprot:ADEQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ADEQ_ECOLI inforesidue swissprot:ADEQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ADEQ_ECOLI octanol swissprot:ADEQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ADEQ_ECOLI pepcoil swissprot:ADEQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ADEQ_ECOLI pepdigest swissprot:ADEQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ADEQ_ECOLI pepinfo swissprot:ADEQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ADEQ_ECOLI pepnet swissprot:ADEQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ADEQ_ECOLI pepstats swissprot:ADEQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ADEQ_ECOLI pepwheel swissprot:ADEQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ADEQ_ECOLI pepwindow swissprot:ADEQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ADEQ_ECOLI sigcleave swissprot:ADEQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ADEQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4259636 8 # EcoGene EG12500 yjfZ # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # IntAct P39308 2 # InterPro IPR021220 DUF2686 # Organism YJFZ_ECOLI Escherichia coli (strain K12) # PATRIC 32123983 VBIEscCol129921_4336 # PIR S56429 S56429 # Pfam PF10887 DUF2686 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJFZ_ECOLI Uncharacterized protein YjfZ # RefSeq NP_418625 NC_000913.3 # RefSeq WP_000174714 NZ_LN832404.1 # SIMILARITY To E.coli YjiC. {ECO 0000305}. # SUBCELLULAR LOCATION YJFZ_ECOLI Membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. BLAST swissprot:YJFZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJFZ_ECOLI BioCyc ECOL316407:JW4162-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4162-MONOMER BioCyc EcoCyc:G7862-MONOMER http://biocyc.org/getid?id=EcoCyc:G7862-MONOMER DIP DIP-12598N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12598N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2393 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2393 EcoGene EG12500 http://www.ecogene.org/geneInfo.php?eg_id=EG12500 EnsemblBacteria AAC77161 http://www.ensemblgenomes.org/id/AAC77161 EnsemblBacteria AAC77161 http://www.ensemblgenomes.org/id/AAC77161 EnsemblBacteria BAE78205 http://www.ensemblgenomes.org/id/BAE78205 EnsemblBacteria BAE78205 http://www.ensemblgenomes.org/id/BAE78205 EnsemblBacteria BAE78205 http://www.ensemblgenomes.org/id/BAE78205 EnsemblBacteria b4204 http://www.ensemblgenomes.org/id/b4204 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GeneID 948719 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948719 HOGENOM HOG000009815 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009815&db=HOGENOM6 IntAct P39308 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39308* InterPro IPR021220 http://www.ebi.ac.uk/interpro/entry/IPR021220 KEGG_Gene ecj:JW4162 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4162 KEGG_Gene eco:b4204 http://www.genome.jp/dbget-bin/www_bget?eco:b4204 MINT MINT-1323741 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1323741 OMA YIDQLHT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YIDQLHT PSORT swissprot:YJFZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJFZ_ECOLI PSORT-B swissprot:YJFZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJFZ_ECOLI PSORT2 swissprot:YJFZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJFZ_ECOLI Pfam PF10887 http://pfam.xfam.org/family/PF10887 Phobius swissprot:YJFZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJFZ_ECOLI ProteinModelPortal P39308 http://www.proteinmodelportal.org/query/uniprot/P39308 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418625 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418625 RefSeq WP_000174714 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000174714 UniProtKB YJFZ_ECOLI http://www.uniprot.org/uniprot/YJFZ_ECOLI UniProtKB-AC P39308 http://www.uniprot.org/uniprot/P39308 charge swissprot:YJFZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJFZ_ECOLI epestfind swissprot:YJFZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJFZ_ECOLI garnier swissprot:YJFZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJFZ_ECOLI helixturnhelix swissprot:YJFZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJFZ_ECOLI hmoment swissprot:YJFZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJFZ_ECOLI iep swissprot:YJFZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJFZ_ECOLI inforesidue swissprot:YJFZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJFZ_ECOLI octanol swissprot:YJFZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJFZ_ECOLI pepcoil swissprot:YJFZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJFZ_ECOLI pepdigest swissprot:YJFZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJFZ_ECOLI pepinfo swissprot:YJFZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJFZ_ECOLI pepnet swissprot:YJFZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJFZ_ECOLI pepstats swissprot:YJFZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJFZ_ECOLI pepwheel swissprot:YJFZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJFZ_ECOLI pepwindow swissprot:YJFZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJFZ_ECOLI sigcleave swissprot:YJFZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJFZ_ECOLI ## Database ID URL or Descriptions # BioGrid 4261652 151 # CATALYTIC ACTIVITY DNAB_ECOLI ATP + H(2)O = ADP + phosphate. # CDD cd00984 DnaB_C # EcoGene EG10236 dnaB # FUNCTION DNAB_ECOLI Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:1990077 primosome complex; IEA:UniProtKB-KW. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003678 DNA helicase activity; IDA:EcoCyc. # GO_function GO:0004386 helicase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0006260 DNA replication; IMP:EcoCyc. # GO_process GO:0006268 DNA unwinding involved in DNA replication; IDA:EcoCyc. # GO_process GO:0006269 DNA replication, synthesis of RNA primer; IEA:UniProtKB-KW. # GO_process GO:0010212 response to ionizing radiation; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004386 helicase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0051276 chromosome organization # Gene3D 1.10.860.10 -; 1. # Gene3D 3.40.50.300 -; 1. # INDUCTION Slightly induced by hydroxyurea. {ECO:0000269|PubMed 20005847}. # INTERACTION DNAB_ECOLI Self; NbExp=3; IntAct=EBI-548978, EBI-548978; P03004 dnaA; NbExp=4; IntAct=EBI-548978, EBI-548951; P0AEF0 dnaC; NbExp=9; IntAct=EBI-548978, EBI-549012; P0ABS5 dnaG; NbExp=3; IntAct=EBI-548978, EBI-549259; P06710 dnaX; NbExp=2; IntAct=EBI-548978, EBI-549140; P23862 priC; NbExp=5; IntAct=EBI-548978, EBI-1117383; P09980 rep; NbExp=3; IntAct=EBI-548978, EBI-6558011; # IntAct P0ACB0 38 # InterPro IPR003593 AAA+_ATPase # InterPro IPR007692 DNA_helicase_DnaB # InterPro IPR007693 DNA_helicase_DnaB-like_N # InterPro IPR007694 DNA_helicase_DnaB-like_C # InterPro IPR016136 DNA_helicase_N/primase_C # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03032 DNA replication proteins # KEGG_Pathway ko03030 DNA replication # KEGG_Pathway ko04112 Cell cycle - Caulobacter # Organism DNAB_ECOLI Escherichia coli (strain K12) # PATRIC 32123643 VBIEscCol129921_4170 # PDB 1B79 X-ray; 2.30 A; A/B/C/D=16-129 # PDB 1JWE NMR; -; A=24-137 # PIR C65213 IQECDB # PROSITE PS51199 SF4_HELICASE # Pfam PF00772 DnaB # Pfam PF03796 DnaB_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DNAB_ECOLI Replicative DNA helicase # RefSeq NP_418476 NC_000913.3 # RefSeq WP_000918363 NZ_LN832404.1 # SIMILARITY Belongs to the helicase family. DnaB subfamily. {ECO 0000305}. # SIMILARITY Contains 1 SF4 helicase domain. {ECO:0000255|PROSITE- ProRule PRU00596}. # SMART SM00382 AAA # SUBUNIT DNAB_ECOLI Homohexamer. # SUPFAM SSF48024 SSF48024 # SUPFAM SSF52540 SSF52540; 2 # TIGRFAMs TIGR00665 DnaB # eggNOG COG0305 LUCA # eggNOG ENOG4105CDU Bacteria BLAST swissprot:DNAB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DNAB_ECOLI BioCyc ECOL316407:JW4012-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4012-MONOMER BioCyc EcoCyc:EG10236-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10236-MONOMER BioCyc MetaCyc:EG10236-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10236-MONOMER COG COG0305 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0305 DIP DIP-9456N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9456N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/S0969-2126(99)80089-6 http://dx.doi.org/10.1016/S0969-2126(99)80089-6 DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.4.12 http://www.genome.jp/dbget-bin/www_bget?EC:3.6.4.12 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K01174 http://www.ebi.ac.uk/ena/data/view/K01174 EMBL L02312 http://www.ebi.ac.uk/ena/data/view/L02312 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.6.4.12 http://enzyme.expasy.org/EC/3.6.4.12 EchoBASE EB0232 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0232 EcoGene EG10236 http://www.ecogene.org/geneInfo.php?eg_id=EG10236 EnsemblBacteria AAC77022 http://www.ensemblgenomes.org/id/AAC77022 EnsemblBacteria AAC77022 http://www.ensemblgenomes.org/id/AAC77022 EnsemblBacteria BAE78054 http://www.ensemblgenomes.org/id/BAE78054 EnsemblBacteria BAE78054 http://www.ensemblgenomes.org/id/BAE78054 EnsemblBacteria BAE78054 http://www.ensemblgenomes.org/id/BAE78054 EnsemblBacteria b4052 http://www.ensemblgenomes.org/id/b4052 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:1990077 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990077 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003678 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003678 GO_function GO:0004386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004386 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260 GO_process GO:0006268 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006268 GO_process GO:0006269 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006269 GO_process GO:0010212 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010212 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004386 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0051276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051276 Gene3D 1.10.860.10 http://www.cathdb.info/version/latest/superfamily/1.10.860.10 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948555 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948555 HOGENOM HOG000113196 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000113196&db=HOGENOM6 InParanoid P0ACB0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACB0 IntAct P0ACB0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACB0* IntEnz 3.6.4.12 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.4.12 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR007692 http://www.ebi.ac.uk/interpro/entry/IPR007692 InterPro IPR007693 http://www.ebi.ac.uk/interpro/entry/IPR007693 InterPro IPR007694 http://www.ebi.ac.uk/interpro/entry/IPR007694 InterPro IPR016136 http://www.ebi.ac.uk/interpro/entry/IPR016136 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03032 http://www.genome.jp/dbget-bin/www_bget?ko03032 KEGG_Gene ecj:JW4012 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4012 KEGG_Gene eco:b4052 http://www.genome.jp/dbget-bin/www_bget?eco:b4052 KEGG_Orthology KO:K02314 http://www.genome.jp/dbget-bin/www_bget?KO:K02314 KEGG_Pathway ko03030 http://www.genome.jp/kegg-bin/show_pathway?ko03030 KEGG_Pathway ko04112 http://www.genome.jp/kegg-bin/show_pathway?ko04112 MINT MINT-584605 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-584605 OMA FQIAEAR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FQIAEAR PDB 1B79 http://www.ebi.ac.uk/pdbe-srv/view/entry/1B79 PDB 1JWE http://www.ebi.ac.uk/pdbe-srv/view/entry/1JWE PDBsum 1B79 http://www.ebi.ac.uk/pdbsum/1B79 PDBsum 1JWE http://www.ebi.ac.uk/pdbsum/1JWE PROSITE PS51199 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51199 PSORT swissprot:DNAB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DNAB_ECOLI PSORT-B swissprot:DNAB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DNAB_ECOLI PSORT2 swissprot:DNAB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DNAB_ECOLI Pfam PF00772 http://pfam.xfam.org/family/PF00772 Pfam PF03796 http://pfam.xfam.org/family/PF03796 Phobius swissprot:DNAB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DNAB_ECOLI PhylomeDB P0ACB0 http://phylomedb.org/?seqid=P0ACB0 ProteinModelPortal P0ACB0 http://www.proteinmodelportal.org/query/uniprot/P0ACB0 PubMed 10404597 http://www.ncbi.nlm.nih.gov/pubmed/10404597 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 6323420 http://www.ncbi.nlm.nih.gov/pubmed/6323420 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_418476 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418476 RefSeq WP_000918363 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000918363 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P0ACB0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACB0 STRING 511145.b4052 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4052&targetmode=cogs STRING COG0305 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0305&targetmode=cogs SUPFAM SSF48024 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48024 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SWISS-2DPAGE P0ACB0 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0ACB0 TIGRFAMs TIGR00665 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00665 UniProtKB DNAB_ECOLI http://www.uniprot.org/uniprot/DNAB_ECOLI UniProtKB-AC P0ACB0 http://www.uniprot.org/uniprot/P0ACB0 charge swissprot:DNAB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DNAB_ECOLI eggNOG COG0305 http://eggnogapi.embl.de/nog_data/html/tree/COG0305 eggNOG ENOG4105CDU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CDU epestfind swissprot:DNAB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DNAB_ECOLI garnier swissprot:DNAB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DNAB_ECOLI helixturnhelix swissprot:DNAB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DNAB_ECOLI hmoment swissprot:DNAB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DNAB_ECOLI iep swissprot:DNAB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DNAB_ECOLI inforesidue swissprot:DNAB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DNAB_ECOLI octanol swissprot:DNAB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DNAB_ECOLI pepcoil swissprot:DNAB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DNAB_ECOLI pepdigest swissprot:DNAB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DNAB_ECOLI pepinfo swissprot:DNAB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DNAB_ECOLI pepnet swissprot:DNAB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DNAB_ECOLI pepstats swissprot:DNAB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DNAB_ECOLI pepwheel swissprot:DNAB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DNAB_ECOLI pepwindow swissprot:DNAB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DNAB_ECOLI sigcleave swissprot:DNAB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DNAB_ECOLI ## Database ID URL or Descriptions # BioGrid 4262268 9 # EcoGene EG13287 nrdI # FUNCTION NRDI_ECOLI Probably involved in ribonucleotide reductase function. {ECO 0000250}. # GO_function GO:0010181 FMN binding; IDA:EcoCyc. # GO_process GO:0006464 cellular protein modification process; IDA:EcoCyc. # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # Gene3D 3.40.50.360 -; 1. # HAMAP MF_00128 NrdI # INDUCTION Induced 2-fold by hydroxyurea. {ECO:0000269|PubMed 20005847}. # IntAct P0A772 26 # InterPro IPR004465 RNR_NrdI # InterPro IPR020852 RNR_Ib_NrdI_bac # InterPro IPR029039 Flavoprotein-like_dom # Organism NRDI_ECOLI Escherichia coli (strain K12) # PATRIC 32120738 VBIEscCol129921_2766 # PDB 3N39 X-ray; 2.50 A; C/D=1-133 # PDB 3N3A X-ray; 1.99 A; C/D=1-133 # PDB 3N3B X-ray; 2.36 A; C/D=1-133 # PIR S70890 S70890 # PIRSF PIRSF005087 NrdI # Pfam PF07972 Flavodoxin_NdrI # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NRDI_ECOLI Protein NrdI # RefSeq NP_417160 NC_000913.3 # RefSeq WP_000080947 NZ_LN832404.1 # SIMILARITY Belongs to the NrdI family. {ECO 0000305}. # SUPFAM SSF52218 SSF52218 # TIGRFAMs TIGR00333 nrdI # eggNOG COG1780 LUCA # eggNOG ENOG4105G3E Bacteria BLAST swissprot:NRDI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NRDI_ECOLI BioCyc ECOL316407:JW2649-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2649-MONOMER BioCyc EcoCyc:G7402-MONOMER http://biocyc.org/getid?id=EcoCyc:G7402-MONOMER COG COG1780 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1780 DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1996.424950.x http://dx.doi.org/10.1046/j.1365-2958.1996.424950.x DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X79787 http://www.ebi.ac.uk/ena/data/view/X79787 EchoBASE EB3072 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3072 EcoGene EG13287 http://www.ecogene.org/geneInfo.php?eg_id=EG13287 EnsemblBacteria AAC75721 http://www.ensemblgenomes.org/id/AAC75721 EnsemblBacteria AAC75721 http://www.ensemblgenomes.org/id/AAC75721 EnsemblBacteria BAA16538 http://www.ensemblgenomes.org/id/BAA16538 EnsemblBacteria BAA16538 http://www.ensemblgenomes.org/id/BAA16538 EnsemblBacteria BAA16538 http://www.ensemblgenomes.org/id/BAA16538 EnsemblBacteria b2674 http://www.ensemblgenomes.org/id/b2674 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0010181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010181 GO_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 Gene3D 3.40.50.360 http://www.cathdb.info/version/latest/superfamily/3.40.50.360 GeneID 947158 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947158 HAMAP MF_00128 http://hamap.expasy.org/unirule/MF_00128 HOGENOM HOG000246177 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000246177&db=HOGENOM6 InParanoid P0A772 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A772 IntAct P0A772 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A772* InterPro IPR004465 http://www.ebi.ac.uk/interpro/entry/IPR004465 InterPro IPR020852 http://www.ebi.ac.uk/interpro/entry/IPR020852 InterPro IPR029039 http://www.ebi.ac.uk/interpro/entry/IPR029039 KEGG_Gene ecj:JW2649 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2649 KEGG_Gene eco:b2674 http://www.genome.jp/dbget-bin/www_bget?eco:b2674 KEGG_Orthology KO:K03647 http://www.genome.jp/dbget-bin/www_bget?KO:K03647 OMA NTHRFVG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NTHRFVG PDB 3N39 http://www.ebi.ac.uk/pdbe-srv/view/entry/3N39 PDB 3N3A http://www.ebi.ac.uk/pdbe-srv/view/entry/3N3A PDB 3N3B http://www.ebi.ac.uk/pdbe-srv/view/entry/3N3B PDBsum 3N39 http://www.ebi.ac.uk/pdbsum/3N39 PDBsum 3N3A http://www.ebi.ac.uk/pdbsum/3N3A PDBsum 3N3B http://www.ebi.ac.uk/pdbsum/3N3B PSORT swissprot:NRDI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NRDI_ECOLI PSORT-B swissprot:NRDI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NRDI_ECOLI PSORT2 swissprot:NRDI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NRDI_ECOLI Pfam PF07972 http://pfam.xfam.org/family/PF07972 Phobius swissprot:NRDI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NRDI_ECOLI PhylomeDB P0A772 http://phylomedb.org/?seqid=P0A772 ProteinModelPortal P0A772 http://www.proteinmodelportal.org/query/uniprot/P0A772 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 8820648 http://www.ncbi.nlm.nih.gov/pubmed/8820648 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417160 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417160 RefSeq WP_000080947 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000080947 SMR P0A772 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A772 STRING 511145.b2674 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2674&targetmode=cogs STRING COG1780 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1780&targetmode=cogs SUPFAM SSF52218 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52218 TIGRFAMs TIGR00333 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00333 UniProtKB NRDI_ECOLI http://www.uniprot.org/uniprot/NRDI_ECOLI UniProtKB-AC P0A772 http://www.uniprot.org/uniprot/P0A772 charge swissprot:NRDI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NRDI_ECOLI eggNOG COG1780 http://eggnogapi.embl.de/nog_data/html/tree/COG1780 eggNOG ENOG4105G3E http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105G3E epestfind swissprot:NRDI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NRDI_ECOLI garnier swissprot:NRDI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NRDI_ECOLI helixturnhelix swissprot:NRDI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NRDI_ECOLI hmoment swissprot:NRDI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NRDI_ECOLI iep swissprot:NRDI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NRDI_ECOLI inforesidue swissprot:NRDI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NRDI_ECOLI octanol swissprot:NRDI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NRDI_ECOLI pepcoil swissprot:NRDI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NRDI_ECOLI pepdigest swissprot:NRDI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NRDI_ECOLI pepinfo swissprot:NRDI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NRDI_ECOLI pepnet swissprot:NRDI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NRDI_ECOLI pepstats swissprot:NRDI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NRDI_ECOLI pepwheel swissprot:NRDI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NRDI_ECOLI pepwindow swissprot:NRDI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NRDI_ECOLI sigcleave swissprot:NRDI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NRDI_ECOLI ## Database ID URL or Descriptions # BioGrid 4262818 6 # CAUTION Although the solution structure of this protein has been solved it has not been shown to be expressed in E.coli. {ECO 0000305}. # EcoGene EG12879 ybcJ # FUNCTION YBCJ_ECOLI Its structure and the presence of conserved basic residues indicates that it probably binds RNA. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003723 RNA binding; ISS:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # Gene3D 3.10.290.10 -; 1. # IntAct P0AAS7 48 # InterPro IPR002942 S4_RNA-bd # KEGG_Brite ko03009 Ribosome biogenesis # Organism YBCJ_ECOLI Escherichia coli (strain K12) # PATRIC 32116216 VBIEscCol129921_0549 # PDB 1P9K NMR; -; A=1-70 # PIR G64784 G64784 # PROSITE PS50889 S4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBCJ_ECOLI Uncharacterized protein YbcJ # RefSeq NP_415061 NC_000913.3 # RefSeq WP_000190288 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40281.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=Ref.1; Type=Frameshift; Positions=26; Evidence={ECO 0000305}; # SIMILARITY Contains 1 S4 RNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00182}. # eggNOG COG2501 LUCA # eggNOG ENOG4105WQ3 Bacteria BLAST swissprot:YBCJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBCJ_ECOLI BioCyc ECOL316407:JW5070-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5070-MONOMER BioCyc EcoCyc:EG12879-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12879-MONOMER COG COG2501 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2501 DIP DIP-47878N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47878N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.185.14.4204-4210.2003 http://dx.doi.org/10.1128/JB.185.14.4204-4210.2003 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D10588 http://www.ebi.ac.uk/ena/data/view/D10588 EMBL M74789 http://www.ebi.ac.uk/ena/data/view/M74789 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EchoBASE EB2717 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2717 EcoGene EG12879 http://www.ecogene.org/geneInfo.php?eg_id=EG12879 EnsemblBacteria AAC73630 http://www.ensemblgenomes.org/id/AAC73630 EnsemblBacteria AAC73630 http://www.ensemblgenomes.org/id/AAC73630 EnsemblBacteria BAE76305 http://www.ensemblgenomes.org/id/BAE76305 EnsemblBacteria BAE76305 http://www.ensemblgenomes.org/id/BAE76305 EnsemblBacteria BAE76305 http://www.ensemblgenomes.org/id/BAE76305 EnsemblBacteria b0528 http://www.ensemblgenomes.org/id/b0528 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 Gene3D 3.10.290.10 http://www.cathdb.info/version/latest/superfamily/3.10.290.10 GeneID 945158 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945158 HOGENOM HOG000074028 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000074028&db=HOGENOM6 InParanoid P0AAS7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAS7 IntAct P0AAS7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAS7* InterPro IPR002942 http://www.ebi.ac.uk/interpro/entry/IPR002942 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW5070 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5070 KEGG_Gene eco:b0528 http://www.genome.jp/dbget-bin/www_bget?eco:b0528 KEGG_Orthology KO:K14761 http://www.genome.jp/dbget-bin/www_bget?KO:K14761 MINT MINT-1218447 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1218447 OMA QGWSESG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QGWSESG PDB 1P9K http://www.ebi.ac.uk/pdbe-srv/view/entry/1P9K PDBsum 1P9K http://www.ebi.ac.uk/pdbsum/1P9K PROSITE PS50889 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50889 PSORT swissprot:YBCJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBCJ_ECOLI PSORT-B swissprot:YBCJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBCJ_ECOLI PSORT2 swissprot:YBCJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBCJ_ECOLI Phobius swissprot:YBCJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBCJ_ECOLI PhylomeDB P0AAS7 http://phylomedb.org/?seqid=P0AAS7 ProteinModelPortal P0AAS7 http://www.proteinmodelportal.org/query/uniprot/P0AAS7 PubMed 12837795 http://www.ncbi.nlm.nih.gov/pubmed/12837795 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1748668 http://www.ncbi.nlm.nih.gov/pubmed/1748668 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415061 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415061 RefSeq WP_000190288 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000190288 SMR P0AAS7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAS7 STRING 511145.b0528 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0528&targetmode=cogs STRING COG2501 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2501&targetmode=cogs UniProtKB YBCJ_ECOLI http://www.uniprot.org/uniprot/YBCJ_ECOLI UniProtKB-AC P0AAS7 http://www.uniprot.org/uniprot/P0AAS7 charge swissprot:YBCJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBCJ_ECOLI eggNOG COG2501 http://eggnogapi.embl.de/nog_data/html/tree/COG2501 eggNOG ENOG4105WQ3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105WQ3 epestfind swissprot:YBCJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBCJ_ECOLI garnier swissprot:YBCJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBCJ_ECOLI helixturnhelix swissprot:YBCJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBCJ_ECOLI hmoment swissprot:YBCJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBCJ_ECOLI iep swissprot:YBCJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBCJ_ECOLI inforesidue swissprot:YBCJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBCJ_ECOLI octanol swissprot:YBCJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBCJ_ECOLI pepcoil swissprot:YBCJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBCJ_ECOLI pepdigest swissprot:YBCJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBCJ_ECOLI pepinfo swissprot:YBCJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBCJ_ECOLI pepnet swissprot:YBCJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBCJ_ECOLI pepstats swissprot:YBCJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBCJ_ECOLI pepwheel swissprot:YBCJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBCJ_ECOLI pepwindow swissprot:YBCJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBCJ_ECOLI sigcleave swissprot:YBCJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBCJ_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES MACB_ECOLI Kinetic parameters KM=0.38 mM for ATP (in the presence of MacA) {ECO 0000269|PubMed 17214741}; KM=2.30 mM for ATP (in the absence of MacA) {ECO 0000269|PubMed 17214741}; Note=kcat is 0.78 sec(-1) for ATP in the presence of MacA. kcat is 0.10 sec(-1) for ATP in the absence of MacA.; # BioGrid 4261698 110 # ENZYME REGULATION MACB_ECOLI ATPase activity is stimulated by interaction with MacA and inhibited by vanadate. {ECO 0000269|PubMed 17214741, ECO 0000269|PubMed 18955484, ECO 0000269|PubMed 21696464}. # EcoGene EG13695 macB # FUNCTION MACB_ECOLI Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. When overexpressed, the system confers resistance against macrolides composed of 14- and 15-membered lactones but no or weak resistance against 16-membered ones. In addition, the system could also transport R-LPS or a similar glycolipid. {ECO 0000269|PubMed 11544226, ECO 0000269|PubMed 17214741, ECO 0000269|PubMed 18955484, ECO 0000269|PubMed 23974027}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IDA:EcoliWiki. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IEA:UniProtKB-HAMAP. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008559 xenobiotic-transporting ATPase activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IPI:IntAct. # GO_function GO:0042895 antibiotic transporter activity; IMP:EcoCyc. # GO_process GO:0006855 drug transmembrane transport; IMP:EcoCyc. # GO_process GO:0046677 response to antibiotic; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0055085 transmembrane transport # Gene3D 3.40.50.300 -; 1. # INTERACTION MACB_ECOLI Self; NbExp=4; IntAct=EBI-1125580, EBI-1125580; P75830 macA; NbExp=2; IntAct=EBI-1125580, EBI-551961; # IntAct P75831 3 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR003838 ABC_permease_dom # InterPro IPR017871 ABC_transporter_CS # InterPro IPR017911 ABC_transptr_macrolide_ATP-bd # InterPro IPR025857 MacB_PCD # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism MACB_ECOLI Escherichia coli (strain K12) # PATRIC 32116967 VBIEscCol129921_0909 # PIR G64826 G64826 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # PROSITE PS51267 MACB # Pfam PF00005 ABC_tran # Pfam PF02687 FtsX # Pfam PF12704 MacB_PCD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Macrolide export ATP-binding/permease protein MacB {ECO:0000255|HAMAP-Rule MF_01720} # RefSeq NP_415400 NC_000913.3 # RefSeq WP_000188144 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3.A.1.122) family. {ECO:0000255|HAMAP-Rule MF_01720}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|HAMAP- Rule MF_01720}. # SMART SM00382 AAA # SUBCELLULAR LOCATION MACB_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01720, ECO 0000269|PubMed 11544226, ECO 0000269|PubMed 17214741}; Multi-pass membrane protein {ECO 0000255|HAMAP-Rule MF_01720, ECO 0000269|PubMed 11544226, ECO 0000269|PubMed 17214741}. # SUBUNIT MACB_ECOLI Homodimer. Part of the tripartite efflux system MacAB- TolC, which is composed of an inner membrane transporter, MacB, a periplasmic membrane fusion protein, MacA, and an outer membrane component, TolC. The complex forms a large protein conduit and can translocate molecules across both the inner and outer membranes. Interacts with MacA. {ECO 0000255|HAMAP-Rule MF_01720, ECO 0000269|PubMed 17214741, ECO 0000269|PubMed 18955484, ECO 0000269|PubMed 21696464}. # SUPFAM SSF52540 SSF52540 # TCDB 3.A.1.122 the atp-binding cassette (abc) superfamily # eggNOG COG0577 LUCA # eggNOG COG1136 LUCA # eggNOG ENOG4105D6C Bacteria BLAST swissprot:MACB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MACB_ECOLI BioCyc ECOL316407:JW0863-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0863-MONOMER BioCyc EcoCyc:MACB http://biocyc.org/getid?id=EcoCyc:MACB COG COG0577 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0577 COG COG1136 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1136 DOI 10.1016/S0014-5793(03)00579-9 http://dx.doi.org/10.1016/S0014-5793(03)00579-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M806964200 http://dx.doi.org/10.1074/jbc.M806964200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.2006.05549.x http://dx.doi.org/10.1111/j.1365-2958.2006.05549.x DOI 10.1111/j.1365-2958.2011.07744.x http://dx.doi.org/10.1111/j.1365-2958.2011.07744.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00756-13 http://dx.doi.org/10.1128/JB.00756-13 DOI 10.1128/JB.183.19.5639-5644.2001 http://dx.doi.org/10.1128/JB.183.19.5639-5644.2001 EC_number EC:3.6.3.- {ECO:0000255|HAMAP-Rule:MF_01720} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.- {ECO:0000255|HAMAP-Rule:MF_01720} EMBL AB071146 http://www.ebi.ac.uk/ena/data/view/AB071146 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.6.3.- {ECO:0000255|HAMAP-Rule:MF_01720} http://enzyme.expasy.org/EC/3.6.3.- {ECO:0000255|HAMAP-Rule:MF_01720} EchoBASE EB3459 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3459 EcoGene EG13695 http://www.ecogene.org/geneInfo.php?eg_id=EG13695 EnsemblBacteria AAC73966 http://www.ensemblgenomes.org/id/AAC73966 EnsemblBacteria AAC73966 http://www.ensemblgenomes.org/id/AAC73966 EnsemblBacteria BAA35598 http://www.ensemblgenomes.org/id/BAA35598 EnsemblBacteria BAA35598 http://www.ensemblgenomes.org/id/BAA35598 EnsemblBacteria BAA35598 http://www.ensemblgenomes.org/id/BAA35598 EnsemblBacteria b0879 http://www.ensemblgenomes.org/id/b0879 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008559 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008559 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0042895 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042895 GO_process GO:0006855 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006855 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945164 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945164 HOGENOM HOG000208217 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000208217&db=HOGENOM6 InParanoid P75831 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75831 IntAct P75831 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75831* IntEnz 3.6.3.- {ECO:0000255|HAMAP-Rule:MF_01720} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.- {ECO:0000255|HAMAP-Rule:MF_01720} InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR003838 http://www.ebi.ac.uk/interpro/entry/IPR003838 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR017911 http://www.ebi.ac.uk/interpro/entry/IPR017911 InterPro IPR025857 http://www.ebi.ac.uk/interpro/entry/IPR025857 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0863 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0863 KEGG_Gene eco:b0879 http://www.genome.jp/dbget-bin/www_bget?eco:b0879 KEGG_Orthology KO:K05685 http://www.genome.jp/dbget-bin/www_bget?KO:K05685 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA MAWRAMA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MAWRAMA PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PROSITE PS51267 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51267 PSORT swissprot:MACB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MACB_ECOLI PSORT-B swissprot:MACB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MACB_ECOLI PSORT2 swissprot:MACB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MACB_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Pfam PF02687 http://pfam.xfam.org/family/PF02687 Pfam PF12704 http://pfam.xfam.org/family/PF12704 Phobius swissprot:MACB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MACB_ECOLI PhylomeDB P75831 http://phylomedb.org/?seqid=P75831 ProteinModelPortal P75831 http://www.proteinmodelportal.org/query/uniprot/P75831 PubMed 11544226 http://www.ncbi.nlm.nih.gov/pubmed/11544226 PubMed 12832048 http://www.ncbi.nlm.nih.gov/pubmed/12832048 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17214741 http://www.ncbi.nlm.nih.gov/pubmed/17214741 PubMed 18955484 http://www.ncbi.nlm.nih.gov/pubmed/18955484 PubMed 21696464 http://www.ncbi.nlm.nih.gov/pubmed/21696464 PubMed 23974027 http://www.ncbi.nlm.nih.gov/pubmed/23974027 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415400 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415400 RefSeq WP_000188144 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000188144 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P75831 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75831 STRING 511145.b0879 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0879&targetmode=cogs STRING COG0577 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0577&targetmode=cogs STRING COG1136 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1136&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.122 http://www.tcdb.org/search/result.php?tc=3.A.1.122 UniProtKB MACB_ECOLI http://www.uniprot.org/uniprot/MACB_ECOLI UniProtKB-AC P75831 http://www.uniprot.org/uniprot/P75831 charge swissprot:MACB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MACB_ECOLI eggNOG COG0577 http://eggnogapi.embl.de/nog_data/html/tree/COG0577 eggNOG COG1136 http://eggnogapi.embl.de/nog_data/html/tree/COG1136 eggNOG ENOG4105D6C http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D6C epestfind swissprot:MACB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MACB_ECOLI garnier swissprot:MACB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MACB_ECOLI helixturnhelix swissprot:MACB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MACB_ECOLI hmoment swissprot:MACB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MACB_ECOLI iep swissprot:MACB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MACB_ECOLI inforesidue swissprot:MACB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MACB_ECOLI octanol swissprot:MACB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MACB_ECOLI pepcoil swissprot:MACB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MACB_ECOLI pepdigest swissprot:MACB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MACB_ECOLI pepinfo swissprot:MACB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MACB_ECOLI pepnet swissprot:MACB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MACB_ECOLI pepstats swissprot:MACB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MACB_ECOLI pepwheel swissprot:MACB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MACB_ECOLI pepwindow swissprot:MACB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MACB_ECOLI sigcleave swissprot:MACB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MACB_ECOLI ## Database ID URL or Descriptions # BRENDA 2.7.8.B10 2026 # BioGrid 4259959 389 # CATALYTIC ACTIVITY 2 Phosphatidylglycerol = diphosphatidylglycerol + glycerol. {ECO:0000255|HAMAP- Rule MF_01917}. # DISRUPTION PHENOTYPE Triple deletion of clsA, clsB and clsC results in a complete lack of cardiolipin, regardless of growth phase or growth conditions. {ECO:0000269|PubMed 22988102}. # ENZYME REGULATION Activated by phosphate. Inhibited by cardiolipin and phosphatidate. {ECO:0000269|PubMed 10634942}. # EcoGene EG13671 clsB # FUNCTION CLSB_ECOLI Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. Can also catalyze phosphatidyl group transfer to water to form phosphatidate. {ECO 0000255|HAMAP-Rule MF_01917, ECO 0000269|PubMed 10634942, ECO 0000269|PubMed 22988102}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016020 membrane; IDA:EcoCyc. # GO_function GO:0004630 phospholipase D activity; IDA:EcoliWiki. # GO_function GO:0008808 cardiolipin synthase activity; IDA:EcoCyc. # GO_process GO:0032049 cardiolipin biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # HAMAP MF_01917 Cardiolipin_synth_ClsB # IntAct P0AA84 5 # InterPro IPR001736 PLipase_D/transphosphatidylase # InterPro IPR025202 PLD-like_dom # InterPro IPR030872 Cardiolipin_synth_ClsB # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00564 Glycerophospholipid metabolism # MISCELLANEOUS All three cardiolipin synthases (ClsA, ClsB and ClsC) contribute to CL synthesis in stationary phase. Only ClsA contributes to synthesis during logarithmic growth phase (PubMed:22988102). {ECO 0000305|PubMed:22988102}. # Organism CLSB_ECOLI Escherichia coli (strain K12) # PATRIC 32116779 VBIEscCol129921_0815 # PIR E64815 E64815 # PROSITE PS50035 PLD; 2 # Pfam PF13091 PLDc_2; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Cardiolipin synthase B {ECO:0000255|HAMAP-Rule MF_01917} # RefSeq NP_415310 NC_000913.3 # RefSeq WP_000650337 NZ_LN832404.1 # SIMILARITY Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsB sub-subfamily. {ECO:0000255|HAMAP- Rule MF_01917}. # SIMILARITY Contains 2 PLD phosphodiesterase domains. {ECO:0000255|HAMAP-Rule MF_01917}. # SMART SM00155 PLDc; 2 # SUBCELLULAR LOCATION CLSB_ECOLI Cell membrane {ECO 0000305|PubMed 10634942}; Peripheral membrane protein {ECO 0000305|PubMed 10634942}. # eggNOG COG1502 LUCA # eggNOG ENOG4105DZQ Bacteria BLAST swissprot:CLSB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CLSB_ECOLI BioCyc ECOL316407:JW0772-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0772-MONOMER BioCyc EcoCyc:G6406-MONOMER http://biocyc.org/getid?id=EcoCyc:G6406-MONOMER BioCyc MetaCyc:G6406-MONOMER http://biocyc.org/getid?id=MetaCyc:G6406-MONOMER COG COG1502 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1502 DOI 10.1016/S1388-1981(99)00193-6 http://dx.doi.org/10.1016/S1388-1981(99)00193-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.1212797109 http://dx.doi.org/10.1073/pnas.1212797109 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.8.- {ECO:0000255|HAMAP-Rule:MF_01917} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.8.- {ECO:0000255|HAMAP-Rule:MF_01917} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.8.- {ECO:0000255|HAMAP-Rule:MF_01917} http://enzyme.expasy.org/EC/2.7.8.- {ECO:0000255|HAMAP-Rule:MF_01917} EchoBASE EB3435 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3435 EcoGene EG13671 http://www.ecogene.org/geneInfo.php?eg_id=EG13671 EnsemblBacteria AAC73876 http://www.ensemblgenomes.org/id/AAC73876 EnsemblBacteria AAC73876 http://www.ensemblgenomes.org/id/AAC73876 EnsemblBacteria BAA35448 http://www.ensemblgenomes.org/id/BAA35448 EnsemblBacteria BAA35448 http://www.ensemblgenomes.org/id/BAA35448 EnsemblBacteria BAA35448 http://www.ensemblgenomes.org/id/BAA35448 EnsemblBacteria b0789 http://www.ensemblgenomes.org/id/b0789 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0004630 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004630 GO_function GO:0008808 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008808 GO_process GO:0032049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032049 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 945409 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945409 HAMAP MF_01917 http://hamap.expasy.org/unirule/MF_01917 HOGENOM HOG000264393 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000264393&db=HOGENOM6 InParanoid P0AA84 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AA84 IntAct P0AA84 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AA84* IntEnz 2.7.8.- {ECO:0000255|HAMAP-Rule:MF_01917} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.8.- {ECO:0000255|HAMAP-Rule:MF_01917} InterPro IPR001736 http://www.ebi.ac.uk/interpro/entry/IPR001736 InterPro IPR025202 http://www.ebi.ac.uk/interpro/entry/IPR025202 InterPro IPR030872 http://www.ebi.ac.uk/interpro/entry/IPR030872 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0772 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0772 KEGG_Gene eco:b0789 http://www.genome.jp/dbget-bin/www_bget?eco:b0789 KEGG_Orthology KO:K06132 http://www.genome.jp/dbget-bin/www_bget?KO:K06132 KEGG_Pathway ko00564 http://www.genome.jp/kegg-bin/show_pathway?ko00564 KEGG_Reaction rn:R02030 http://www.genome.jp/dbget-bin/www_bget?rn:R02030 KEGG_Reaction rn:R07390 http://www.genome.jp/dbget-bin/www_bget?rn:R07390 OMA THRKILI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=THRKILI PROSITE PS50035 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50035 PSORT swissprot:CLSB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CLSB_ECOLI PSORT-B swissprot:CLSB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CLSB_ECOLI PSORT2 swissprot:CLSB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CLSB_ECOLI Pfam PF13091 http://pfam.xfam.org/family/PF13091 Phobius swissprot:CLSB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CLSB_ECOLI PhylomeDB P0AA84 http://phylomedb.org/?seqid=P0AA84 ProteinModelPortal P0AA84 http://www.proteinmodelportal.org/query/uniprot/P0AA84 PubMed 10634942 http://www.ncbi.nlm.nih.gov/pubmed/10634942 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22988102 http://www.ncbi.nlm.nih.gov/pubmed/22988102 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415310 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415310 RefSeq WP_000650337 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000650337 SMART SM00155 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00155 SMR P0AA84 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AA84 STRING 511145.b0789 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0789&targetmode=cogs STRING COG1502 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1502&targetmode=cogs UniProtKB CLSB_ECOLI http://www.uniprot.org/uniprot/CLSB_ECOLI UniProtKB-AC P0AA84 http://www.uniprot.org/uniprot/P0AA84 charge swissprot:CLSB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CLSB_ECOLI eggNOG COG1502 http://eggnogapi.embl.de/nog_data/html/tree/COG1502 eggNOG ENOG4105DZQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DZQ epestfind swissprot:CLSB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CLSB_ECOLI garnier swissprot:CLSB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CLSB_ECOLI helixturnhelix swissprot:CLSB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CLSB_ECOLI hmoment swissprot:CLSB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CLSB_ECOLI iep swissprot:CLSB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CLSB_ECOLI inforesidue swissprot:CLSB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CLSB_ECOLI octanol swissprot:CLSB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CLSB_ECOLI pepcoil swissprot:CLSB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CLSB_ECOLI pepdigest swissprot:CLSB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CLSB_ECOLI pepinfo swissprot:CLSB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CLSB_ECOLI pepnet swissprot:CLSB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CLSB_ECOLI pepstats swissprot:CLSB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CLSB_ECOLI pepwheel swissprot:CLSB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CLSB_ECOLI pepwindow swissprot:CLSB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CLSB_ECOLI sigcleave swissprot:CLSB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CLSB_ECOLI ## Database ID URL or Descriptions # BRENDA 2.8.1 2026 # BRENDA 2.8.1 2026 # BRENDA 2.8.1.B1 2026 # BioGrid 4263129 18 # CATALYTIC ACTIVITY MNMA_ECOLI A [protein]-S-sulfanyl-L-cysteine + uridine(34) in tRNA + ATP + reduced acceptor = a [protein]-L- cysteine + 2-thiouridine(34) in tRNA + AMP + diphosphate + acceptor. {ECO 0000269|PubMed 12549933, ECO 0000269|PubMed 16387657}. # CAUTION Was originally thought to be a 5-methylaminomethyl-2- methyltransferase involved in tRNA modification. {ECO 0000305}. # CDD cd01998 tRNA_Me_trans # EcoGene EG11344 mnmA # FUNCTION MNMA_ECOLI Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis. Sulfur is provided by IscS, via a sulfur-relay system. Binds ATP and its substrate tRNAs. {ECO 0000269|PubMed 12549933}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000049 tRNA binding; IEA:UniProtKB-KW. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016783 sulfurtransferase activity; IDA:EcoCyc. # GO_process GO:0002143 tRNA wobble position uridine thiolation; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # Gene3D 2.30.30.280 -; 1. # Gene3D 3.40.50.620 -; 1. # HAMAP MF_00144 tRNA_thiouridyl_MnmA # IntAct P25745 4 # InterPro IPR004506 tRNA-specific_2-thiouridylase # InterPro IPR014729 Rossmann-like_a/b/a_fold # InterPro IPR023382 Adenine_a_hdrlase_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # KEGG_Pathway ko04122 Sulfur relay system # MISCELLANEOUS MNMA_ECOLI During the reaction, ATP is used to activate the C2 atom of U34 by adenylation. After this, the persulfide sulfur on the catalytic cysteine is transferred to the C2 atom of U34. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards the activated C2 atom on U34. Subsequently, Cys-102 acts as nucleophile towards Cys-199, and a transient disulfide bond is formed. # Organism MNMA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11933 PTHR11933 # PATRIC 32117515 VBIEscCol129921_1180 # PDB 2DER X-ray; 3.10 A; A/B=1-368 # PDB 2DET X-ray; 3.40 A; A=1-368 # PDB 2DEU X-ray; 3.40 A; A/B=1-368 # PIR B64858 B64858 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MNMA_ECOLI tRNA-specific 2-thiouridylase MnmA # RefSeq NP_415651 NC_000913.3 # RefSeq WP_001297484 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA41994.1; Type=Frameshift; Positions=175, 215; Evidence={ECO 0000305}; # SIMILARITY Belongs to the MnmA/TRMU family. {ECO 0000305}. # SUBCELLULAR LOCATION MNMA_ECOLI Cytoplasm. # SUBUNIT Interacts with TusE. {ECO:0000269|PubMed 16387657}. # TIGRFAMs TIGR00420 trmU # eggNOG COG0482 LUCA # eggNOG ENOG4105CCJ Bacteria BLAST swissprot:MNMA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MNMA_ECOLI BioCyc ECOL316407:JW1119-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1119-MONOMER BioCyc EcoCyc:EG11344-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11344-MONOMER BioCyc MetaCyc:EG11344-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11344-MONOMER COG COG0482 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0482 DIP DIP-11035N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11035N DOI 10.1016/j.molcel.2005.11.001 http://dx.doi.org/10.1016/j.molcel.2005.11.001 DOI 10.1021/bi026536+ http://dx.doi.org/10.1021/bi026536+ DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature04896 http://dx.doi.org/10.1038/nature04896 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1099/13500872-142-11-3219 http://dx.doi.org/10.1099/13500872-142-11-3219 DOI 10.1107/S174430910600738X http://dx.doi.org/10.1107/S174430910600738X DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.8.1.13 {ECO:0000269|PubMed:12549933, ECO:0000269|PubMed:16387657} http://www.genome.jp/dbget-bin/www_bget?EC:2.8.1.13 {ECO:0000269|PubMed:12549933, ECO:0000269|PubMed:16387657} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M74924 http://www.ebi.ac.uk/ena/data/view/M74924 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X59307 http://www.ebi.ac.uk/ena/data/view/X59307 ENZYME 2.8.1.13 {ECO:0000269|PubMed:12549933, ECO:0000269|PubMed:16387657} http://enzyme.expasy.org/EC/2.8.1.13 {ECO:0000269|PubMed:12549933, ECO:0000269|PubMed:16387657} EchoBASE EB1320 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1320 EcoGene EG11344 http://www.ecogene.org/geneInfo.php?eg_id=EG11344 EnsemblBacteria AAC74217 http://www.ensemblgenomes.org/id/AAC74217 EnsemblBacteria AAC74217 http://www.ensemblgenomes.org/id/AAC74217 EnsemblBacteria BAA35955 http://www.ensemblgenomes.org/id/BAA35955 EnsemblBacteria BAA35955 http://www.ensemblgenomes.org/id/BAA35955 EnsemblBacteria BAA35955 http://www.ensemblgenomes.org/id/BAA35955 EnsemblBacteria b1133 http://www.ensemblgenomes.org/id/b1133 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000049 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016783 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016783 GO_process GO:0002143 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002143 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 Gene3D 2.30.30.280 http://www.cathdb.info/version/latest/superfamily/2.30.30.280 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 GeneID 945690 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945690 HAMAP MF_00144 http://hamap.expasy.org/unirule/MF_00144 HOGENOM HOG000218046 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218046&db=HOGENOM6 InParanoid P25745 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P25745 IntAct P25745 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P25745* IntEnz 2.8.1.13 {ECO:0000269|PubMed:12549933, ECO:0000269|PubMed:16387657} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.8.1.13 {ECO:0000269|PubMed:12549933, ECO:0000269|PubMed:16387657} InterPro IPR004506 http://www.ebi.ac.uk/interpro/entry/IPR004506 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 InterPro IPR023382 http://www.ebi.ac.uk/interpro/entry/IPR023382 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW1119 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1119 KEGG_Gene eco:b1133 http://www.genome.jp/dbget-bin/www_bget?eco:b1133 KEGG_Orthology KO:K00566 http://www.genome.jp/dbget-bin/www_bget?KO:K00566 KEGG_Pathway ko04122 http://www.genome.jp/kegg-bin/show_pathway?ko04122 OMA LHKINFA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LHKINFA PANTHER PTHR11933 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11933 PDB 2DER http://www.ebi.ac.uk/pdbe-srv/view/entry/2DER PDB 2DET http://www.ebi.ac.uk/pdbe-srv/view/entry/2DET PDB 2DEU http://www.ebi.ac.uk/pdbe-srv/view/entry/2DEU PDBsum 2DER http://www.ebi.ac.uk/pdbsum/2DER PDBsum 2DET http://www.ebi.ac.uk/pdbsum/2DET PDBsum 2DEU http://www.ebi.ac.uk/pdbsum/2DEU PSORT swissprot:MNMA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MNMA_ECOLI PSORT-B swissprot:MNMA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MNMA_ECOLI PSORT2 swissprot:MNMA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MNMA_ECOLI Phobius swissprot:MNMA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MNMA_ECOLI PhylomeDB P25745 http://phylomedb.org/?seqid=P25745 ProteinModelPortal P25745 http://www.proteinmodelportal.org/query/uniprot/P25745 PubMed 12549933 http://www.ncbi.nlm.nih.gov/pubmed/12549933 PubMed 16387657 http://www.ncbi.nlm.nih.gov/pubmed/16387657 PubMed 16582487 http://www.ncbi.nlm.nih.gov/pubmed/16582487 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16871210 http://www.ncbi.nlm.nih.gov/pubmed/16871210 PubMed 1729205 http://www.ncbi.nlm.nih.gov/pubmed/1729205 PubMed 3881393 http://www.ncbi.nlm.nih.gov/pubmed/3881393 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 8969519 http://www.ncbi.nlm.nih.gov/pubmed/8969519 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415651 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415651 RefSeq WP_001297484 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001297484 SMR P25745 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P25745 STRING 511145.b1133 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1133&targetmode=cogs STRING COG0482 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0482&targetmode=cogs TIGRFAMs TIGR00420 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00420 UniProtKB MNMA_ECOLI http://www.uniprot.org/uniprot/MNMA_ECOLI UniProtKB-AC P25745 http://www.uniprot.org/uniprot/P25745 charge swissprot:MNMA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MNMA_ECOLI eggNOG COG0482 http://eggnogapi.embl.de/nog_data/html/tree/COG0482 eggNOG ENOG4105CCJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CCJ epestfind swissprot:MNMA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MNMA_ECOLI garnier swissprot:MNMA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MNMA_ECOLI helixturnhelix swissprot:MNMA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MNMA_ECOLI hmoment swissprot:MNMA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MNMA_ECOLI iep swissprot:MNMA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MNMA_ECOLI inforesidue swissprot:MNMA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MNMA_ECOLI octanol swissprot:MNMA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MNMA_ECOLI pepcoil swissprot:MNMA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MNMA_ECOLI pepdigest swissprot:MNMA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MNMA_ECOLI pepinfo swissprot:MNMA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MNMA_ECOLI pepnet swissprot:MNMA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MNMA_ECOLI pepstats swissprot:MNMA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MNMA_ECOLI pepwheel swissprot:MNMA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MNMA_ECOLI pepwindow swissprot:MNMA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MNMA_ECOLI sigcleave swissprot:MNMA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MNMA_ECOLI ## Database ID URL or Descriptions # AltName TOMB_ECOLI Toxin overexpression modulator in biofilms # BioGrid 4259498 27 # DISRUPTION PHENOTYPE Deletion of hha and tomB, in the presence of a conjugative plasmid (R1drd19), decreases biofilm formation, cell aggregation and increases motility via flagella and motility gene expression. {ECO:0000269|PubMed 16317765}. # EcoGene EG12429 tomB # FUNCTION TOMB_ECOLI Attenuates Hha toxicity and regulates biofilm formation. Binds to various coding and intergenic regions of genomic DNA. {ECO 0000269|PubMed 16317765, ECO 0000269|PubMed 18545668}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_process GO:0044010 single-species biofilm formation; IEP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # INDUCTION TOMB_ECOLI Expression is autoregulated (Probable). Induced during biofilm formation. {ECO 0000269|PubMed 14727089, ECO 0000269|PubMed 18545668, ECO 0000305}. # InterPro IPR019693 Biofilm_formation_reg_YbaJ # MISCELLANEOUS TOMB_ECOLI Hha and TomB may form a toxin-antitoxin (TA) module. # Organism TOMB_ECOLI Escherichia coli (strain K12) # PATRIC 32116075 VBIEscCol129921_0479 # PIR D64776 D64776 # Pfam PF10757 YbaJ # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TOMB_ECOLI Hha toxicity modulator TomB # RefSeq NP_414994 NC_000913.3 # RefSeq WP_000344800 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=X57977; Type=Frameshift; Positions=43, 53; Evidence={ECO 0000305}; # SIMILARITY Belongs to the TomB family. {ECO 0000305}. # SUBCELLULAR LOCATION TOMB_ECOLI Cytoplasm {ECO 0000305}. # eggNOG ENOG4108UKR Bacteria # eggNOG ENOG4111JW6 LUCA BLAST swissprot:TOMB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TOMB_ECOLI BioCyc ECOL316407:JW0450-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0450-MONOMER BioCyc EcoCyc:EG12429-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12429-MONOMER DIP DIP-48132N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48132N DOI 10.1002/bit.20681 http://dx.doi.org/10.1002/bit.20681 DOI 10.1007/s00253-003-1517-y http://dx.doi.org/10.1007/s00253-003-1517-y DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1111/j.1365-2958.1991.tb01902.x http://dx.doi.org/10.1111/j.1365-2958.1991.tb01902.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pone.0002394 http://dx.doi.org/10.1371/journal.pone.0002394 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X57977 http://www.ebi.ac.uk/ena/data/view/X57977 EchoBASE EB2326 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2326 EcoGene EG12429 http://www.ecogene.org/geneInfo.php?eg_id=EG12429 EnsemblBacteria AAC73563 http://www.ensemblgenomes.org/id/AAC73563 EnsemblBacteria AAC73563 http://www.ensemblgenomes.org/id/AAC73563 EnsemblBacteria BAE76240 http://www.ensemblgenomes.org/id/BAE76240 EnsemblBacteria BAE76240 http://www.ensemblgenomes.org/id/BAE76240 EnsemblBacteria BAE76240 http://www.ensemblgenomes.org/id/BAE76240 EnsemblBacteria b0461 http://www.ensemblgenomes.org/id/b0461 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0044010 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044010 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 945106 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945106 HOGENOM HOG000219356 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219356&db=HOGENOM6 InterPro IPR019693 http://www.ebi.ac.uk/interpro/entry/IPR019693 KEGG_Gene ecj:JW0450 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0450 KEGG_Gene eco:b0461 http://www.genome.jp/dbget-bin/www_bget?eco:b0461 OMA CERVEKY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CERVEKY PSORT swissprot:TOMB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TOMB_ECOLI PSORT-B swissprot:TOMB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TOMB_ECOLI PSORT2 swissprot:TOMB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TOMB_ECOLI Pfam PF10757 http://pfam.xfam.org/family/PF10757 Phobius swissprot:TOMB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TOMB_ECOLI ProteinModelPortal P0AAR0 http://www.proteinmodelportal.org/query/uniprot/P0AAR0 PubMed 14727089 http://www.ncbi.nlm.nih.gov/pubmed/14727089 PubMed 16317765 http://www.ncbi.nlm.nih.gov/pubmed/16317765 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18545668 http://www.ncbi.nlm.nih.gov/pubmed/18545668 PubMed 1956303 http://www.ncbi.nlm.nih.gov/pubmed/1956303 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414994 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414994 RefSeq WP_000344800 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000344800 SMR P0AAR0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAR0 STRING 511145.b0461 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0461&targetmode=cogs UniProtKB TOMB_ECOLI http://www.uniprot.org/uniprot/TOMB_ECOLI UniProtKB-AC P0AAR0 http://www.uniprot.org/uniprot/P0AAR0 charge swissprot:TOMB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TOMB_ECOLI eggNOG ENOG4108UKR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UKR eggNOG ENOG4111JW6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111JW6 epestfind swissprot:TOMB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TOMB_ECOLI garnier swissprot:TOMB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TOMB_ECOLI helixturnhelix swissprot:TOMB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TOMB_ECOLI hmoment swissprot:TOMB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TOMB_ECOLI iep swissprot:TOMB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TOMB_ECOLI inforesidue swissprot:TOMB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TOMB_ECOLI octanol swissprot:TOMB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TOMB_ECOLI pepcoil swissprot:TOMB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TOMB_ECOLI pepdigest swissprot:TOMB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TOMB_ECOLI pepinfo swissprot:TOMB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TOMB_ECOLI pepnet swissprot:TOMB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TOMB_ECOLI pepstats swissprot:TOMB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TOMB_ECOLI pepwheel swissprot:TOMB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TOMB_ECOLI pepwindow swissprot:TOMB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TOMB_ECOLI sigcleave swissprot:TOMB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TOMB_ECOLI ## Database ID URL or Descriptions # AltName Ubiquinone biosynthesis protein UbiB {ECO:0000255|HAMAP-Rule MF_00414} # BioGrid 4260948 328 # CDD cd13972 UbiB # DISRUPTION PHENOTYPE UBIB_ECOLI Cells lacking this gene fail to produce coenzyme Q8, and accumulate octaprenylphenol (OPP). {ECO 0000269|PubMed 10960098, ECO 0000269|PubMed 9422602}. # EcoGene EG11476 ubiB # FUNCTION UBIB_ECOLI Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. {ECO 0000255|HAMAP-Rule MF_00414, ECO 0000269|PubMed 10960098, ECO 0000269|PubMed 9422602}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0004672 protein kinase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0006744 ubiquinone biosynthetic process; IMP:EcoCyc. # GO_process GO:0010795 regulation of ubiquinone biosynthetic process; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # HAMAP MF_00414 UbiB # IntAct P0A6A0 12 # InterPro IPR004147 UbiB_dom # InterPro IPR010232 UbiB # InterPro IPR011009 Kinase-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Pathway ko00130 Ubiquinone and other terpenoid-quinone biosynthesis # Organism UBIB_ECOLI Escherichia coli (strain K12) # PATHWAY UBIB_ECOLI Cofactor biosynthesis; ubiquinone biosynthesis [regulation]. # PATRIC 32123171 VBIEscCol129921_3951 # PIR D65188 D65188 # Pfam PF03109 ABC1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Probable protein kinase UbiB {ECO:0000255|HAMAP-Rule MF_00414} # RefSeq NP_418279 NC_000913.3 # RefSeq WP_000187530 NZ_LN832404.1 # SIMILARITY Belongs to the ABC1 family. UbiB subfamily. {ECO:0000255|HAMAP-Rule MF_00414}. # SIMILARITY Contains 1 protein kinase domain. {ECO:0000255|HAMAP- Rule MF_00414}. # SUBCELLULAR LOCATION UBIB_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_00414, ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255|HAMAP-Rule MF_00414, ECO 0000269|PubMed 15919996}. # SUPFAM SSF56112 SSF56112; 2 # TIGRFAMs TIGR01982 UbiB # eggNOG COG0661 LUCA # eggNOG ENOG4105CNK Bacteria BLAST swissprot:UBIB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UBIB_ECOLI BioCyc ECOL316407:JW3812-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3812-MONOMER BioCyc EcoCyc:2-OCTAPRENYLPHENOL-HYDROX-MONOMER http://biocyc.org/getid?id=EcoCyc:2-OCTAPRENYLPHENOL-HYDROX-MONOMER COG COG0661 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0661 DIP DIP-35858N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35858N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M113.480368 http://dx.doi.org/10.1074/jbc.M113.480368 DOI 10.1093/nar/15.17.6827 http://dx.doi.org/10.1093/nar/15.17.6827 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.18.5139-5146.2000 http://dx.doi.org/10.1128/JB.182.18.5139-5146.2000 EC_number EC:2.7.-.- {ECO:0000255|HAMAP-Rule:MF_00414} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.-.- {ECO:0000255|HAMAP-Rule:MF_00414} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X05967 http://www.ebi.ac.uk/ena/data/view/X05967 ENZYME 2.7.-.- {ECO:0000255|HAMAP-Rule:MF_00414} http://enzyme.expasy.org/EC/2.7.-.- {ECO:0000255|HAMAP-Rule:MF_00414} EchoBASE EB1443 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1443 EcoGene EG11476 http://www.ecogene.org/geneInfo.php?eg_id=EG11476 EnsemblBacteria AAC76838 http://www.ensemblgenomes.org/id/AAC76838 EnsemblBacteria AAC76838 http://www.ensemblgenomes.org/id/AAC76838 EnsemblBacteria BAE77466 http://www.ensemblgenomes.org/id/BAE77466 EnsemblBacteria BAE77466 http://www.ensemblgenomes.org/id/BAE77466 EnsemblBacteria BAE77466 http://www.ensemblgenomes.org/id/BAE77466 EnsemblBacteria b3835 http://www.ensemblgenomes.org/id/b3835 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0004672 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004672 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006744 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006744 GO_process GO:0010795 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010795 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GeneID 948322 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948322 HAMAP MF_00414 http://hamap.expasy.org/unirule/MF_00414 HOGENOM HOG000264440 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000264440&db=HOGENOM6 InParanoid P0A6A0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6A0 IntAct P0A6A0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6A0* IntEnz 2.7.-.- {ECO:0000255|HAMAP-Rule:MF_00414} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.-.- {ECO:0000255|HAMAP-Rule:MF_00414} InterPro IPR004147 http://www.ebi.ac.uk/interpro/entry/IPR004147 InterPro IPR010232 http://www.ebi.ac.uk/interpro/entry/IPR010232 InterPro IPR011009 http://www.ebi.ac.uk/interpro/entry/IPR011009 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Gene ecj:JW3812 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3812 KEGG_Gene eco:b3835 http://www.genome.jp/dbget-bin/www_bget?eco:b3835 KEGG_Orthology KO:K03688 http://www.genome.jp/dbget-bin/www_bget?KO:K03688 KEGG_Pathway ko00130 http://www.genome.jp/kegg-bin/show_pathway?ko00130 KEGG_Reaction rn:R04987 http://www.genome.jp/dbget-bin/www_bget?rn:R04987 KEGG_Reaction rn:R08768 http://www.genome.jp/dbget-bin/www_bget?rn:R08768 MINT MINT-1224329 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1224329 OMA LIHHAMA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LIHHAMA PSORT swissprot:UBIB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UBIB_ECOLI PSORT-B swissprot:UBIB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UBIB_ECOLI PSORT2 swissprot:UBIB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UBIB_ECOLI Pfam PF03109 http://pfam.xfam.org/family/PF03109 Phobius swissprot:UBIB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UBIB_ECOLI PhylomeDB P0A6A0 http://phylomedb.org/?seqid=P0A6A0 ProteinModelPortal P0A6A0 http://www.proteinmodelportal.org/query/uniprot/P0A6A0 PubMed 10960098 http://www.ncbi.nlm.nih.gov/pubmed/10960098 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 23709220 http://www.ncbi.nlm.nih.gov/pubmed/23709220 PubMed 3309887 http://www.ncbi.nlm.nih.gov/pubmed/3309887 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9422602 http://www.ncbi.nlm.nih.gov/pubmed/9422602 RefSeq NP_418279 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418279 RefSeq WP_000187530 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000187530 SMR P0A6A0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6A0 STRING 511145.b3835 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3835&targetmode=cogs STRING COG0661 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0661&targetmode=cogs SUPFAM SSF56112 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56112 TIGRFAMs TIGR01982 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01982 UniProtKB UBIB_ECOLI http://www.uniprot.org/uniprot/UBIB_ECOLI UniProtKB-AC P0A6A0 http://www.uniprot.org/uniprot/P0A6A0 charge swissprot:UBIB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UBIB_ECOLI eggNOG COG0661 http://eggnogapi.embl.de/nog_data/html/tree/COG0661 eggNOG ENOG4105CNK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CNK epestfind swissprot:UBIB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UBIB_ECOLI garnier swissprot:UBIB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UBIB_ECOLI helixturnhelix swissprot:UBIB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UBIB_ECOLI hmoment swissprot:UBIB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UBIB_ECOLI iep swissprot:UBIB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UBIB_ECOLI inforesidue swissprot:UBIB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UBIB_ECOLI octanol swissprot:UBIB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UBIB_ECOLI pepcoil swissprot:UBIB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UBIB_ECOLI pepdigest swissprot:UBIB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UBIB_ECOLI pepinfo swissprot:UBIB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UBIB_ECOLI pepnet swissprot:UBIB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UBIB_ECOLI pepstats swissprot:UBIB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UBIB_ECOLI pepwheel swissprot:UBIB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UBIB_ECOLI pepwindow swissprot:UBIB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UBIB_ECOLI sigcleave swissprot:UBIB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UBIB_ECOLI ## Database ID URL or Descriptions # BioGrid 4259425 21 # COFACTOR HYDN_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000250}; Note=Binds 4 [4Fe-4S] clusters. {ECO 0000250}; # EcoGene EG11552 hydN # FUNCTION HYDN_ECOLI Electron transport from formate to hydrogen. {ECO 0000269|PubMed 8661925}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0009055 electron carrier activity; IMP:EcoCyc. # GO_function GO:0016491 oxidoreductase activity; IBA:GO_Central. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # IntAct P0AAK4 13 # InterPro IPR017896 4Fe4S_Fe-S-bd # InterPro IPR017900 4Fe4S_Fe_S_CS # Organism HYDN_ECOLI Escherichia coli (strain K12) # PATRIC 32120824 VBIEscCol129921_2804 # PIR E65051 E65051 # PROSITE PS00198 4FE4S_FER_1 # PROSITE PS51379 4FE4S_FER_2; 4 # Pfam PF00037 Fer4 # Pfam PF12798 Fer4_3 # Pfam PF12800 Fer4_4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HYDN_ECOLI Electron transport protein HydN # RefSeq NP_417193 NC_000913.3 # RefSeq WP_001078777 NZ_LN832404.1 # SIMILARITY Contains 4 4Fe-4S ferredoxin-type domains. {ECO:0000255|PROSITE-ProRule PRU00711}. # eggNOG COG1142 LUCA # eggNOG ENOG4108RC0 Bacteria BLAST swissprot:HYDN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HYDN_ECOLI BioCyc ECOL316407:JW2683-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2683-MONOMER BioCyc EcoCyc:EG11552-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11552-MONOMER COG COG1142 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1142 DOI 10.1007/s002030050335 http://dx.doi.org/10.1007/s002030050335 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D14422 http://www.ebi.ac.uk/ena/data/view/D14422 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EchoBASE EB1513 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1513 EcoGene EG11552 http://www.ecogene.org/geneInfo.php?eg_id=EG11552 EnsemblBacteria AAC75755 http://www.ensemblgenomes.org/id/AAC75755 EnsemblBacteria AAC75755 http://www.ensemblgenomes.org/id/AAC75755 EnsemblBacteria BAE76790 http://www.ensemblgenomes.org/id/BAE76790 EnsemblBacteria BAE76790 http://www.ensemblgenomes.org/id/BAE76790 EnsemblBacteria BAE76790 http://www.ensemblgenomes.org/id/BAE76790 EnsemblBacteria b2713 http://www.ensemblgenomes.org/id/b2713 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GeneID 947190 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947190 HOGENOM HOG000163385 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000163385&db=HOGENOM6 InParanoid P0AAK4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAK4 IntAct P0AAK4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAK4* InterPro IPR017896 http://www.ebi.ac.uk/interpro/entry/IPR017896 InterPro IPR017900 http://www.ebi.ac.uk/interpro/entry/IPR017900 KEGG_Gene ecj:JW2683 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2683 KEGG_Gene eco:b2713 http://www.genome.jp/dbget-bin/www_bget?eco:b2713 KEGG_Orthology KO:K05796 http://www.genome.jp/dbget-bin/www_bget?KO:K05796 OMA ACVMAHS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ACVMAHS PROSITE PS00198 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00198 PROSITE PS51379 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51379 PSORT swissprot:HYDN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HYDN_ECOLI PSORT-B swissprot:HYDN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HYDN_ECOLI PSORT2 swissprot:HYDN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HYDN_ECOLI Pfam PF00037 http://pfam.xfam.org/family/PF00037 Pfam PF12798 http://pfam.xfam.org/family/PF12798 Pfam PF12800 http://pfam.xfam.org/family/PF12800 Phobius swissprot:HYDN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HYDN_ECOLI PhylomeDB P0AAK4 http://phylomedb.org/?seqid=P0AAK4 ProteinModelPortal P0AAK4 http://www.proteinmodelportal.org/query/uniprot/P0AAK4 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8661925 http://www.ncbi.nlm.nih.gov/pubmed/8661925 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417193 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417193 RefSeq WP_001078777 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001078777 STRING 511145.b2713 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2713&targetmode=cogs STRING COG1142 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1142&targetmode=cogs UniProtKB HYDN_ECOLI http://www.uniprot.org/uniprot/HYDN_ECOLI UniProtKB-AC P0AAK4 http://www.uniprot.org/uniprot/P0AAK4 charge swissprot:HYDN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HYDN_ECOLI eggNOG COG1142 http://eggnogapi.embl.de/nog_data/html/tree/COG1142 eggNOG ENOG4108RC0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108RC0 epestfind swissprot:HYDN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HYDN_ECOLI garnier swissprot:HYDN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HYDN_ECOLI helixturnhelix swissprot:HYDN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HYDN_ECOLI hmoment swissprot:HYDN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HYDN_ECOLI iep swissprot:HYDN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HYDN_ECOLI inforesidue swissprot:HYDN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HYDN_ECOLI octanol swissprot:HYDN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HYDN_ECOLI pepcoil swissprot:HYDN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HYDN_ECOLI pepdigest swissprot:HYDN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HYDN_ECOLI pepinfo swissprot:HYDN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HYDN_ECOLI pepnet swissprot:HYDN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HYDN_ECOLI pepstats swissprot:HYDN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HYDN_ECOLI pepwheel swissprot:HYDN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HYDN_ECOLI pepwindow swissprot:HYDN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HYDN_ECOLI sigcleave swissprot:HYDN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HYDN_ECOLI ## Database ID URL or Descriptions # AltName DEGS_ECOLI Site-1 protease DegS # AltName DEGS_ECOLI Site-1-type intramembrane protease # BIOPHYSICOCHEMICAL PROPERTIES DEGS_ECOLI Kinetic parameters KM=33 uM for RseA-YQF {ECO 0000269|PubMed 17981123, ECO 0000269|PubMed 19836340}; Vmax=0.6 umol/sec/mg enzyme {ECO 0000269|PubMed 17981123, ECO 0000269|PubMed 19836340}; # CATALYTIC ACTIVITY DEGS_ECOLI Acts on substrates that are at least partially unfolded. The cleavage site P1 residue is normally between a pair of hydrophobic residues, such as Val-|-Val. # DISRUPTION PHENOTYPE DEGS_ECOLI Small, slowly growing colonies. 5-fold decrease in basal sigma-E (RpoE) activity, loss of regular growth regulation of sigma-E. No proteolysis of full-length RseA. {ECO 0000269|PubMed 10500101, ECO 0000269|PubMed 11442831, ECO 0000269|PubMed 12183368, ECO 0000269|PubMed 12183369, ECO 0000269|PubMed 8576051}. # DOMAIN DEGS_ECOLI The PDZ domain probably binds peptides ending with C- terminal Tyr-X-Phe sequences, which activates proteolysis. In the absence of OMP peptides the PDZ domain inhibits peptidase activity. {ECO 0000269|PubMed 12679035, ECO 0000269|PubMed 17360428}. # ENZYME REGULATION DEGS_ECOLI Allosterically activated by the C-terminus of exposed OMP peptides (consensus Tyr-X-Phe-COOH); cleavage only occurs in the presence of peptides. Inhibited when RseB is bound to RseA. {ECO 0000269|PubMed 12679035, ECO 0000269|PubMed 17360428, ECO 0000269|PubMed 17938245, ECO 0000269|PubMed 19836340, ECO 0000269|PubMed 20739286}. # EcoGene EG11652 degS # FUNCTION DEGS_ECOLI A site-1 protease (S1P) that cleaves the peptide bond between 'Val-148' and 'Ser-149' in RseA. Part of a regulated intramembrane proteolysis (RIP) cascade. When heat shock or other environmental stresses disrupt protein folding in the periplasm, DegS senses the accumulation of unassembled outer membrane porins (OMP) and then initiates RseA (anti sigma-E factor) degradation by cleaving its periplasmic domain, making it a substrate for subsequent cleavage by RseP. This cascade ultimately leads to the sigma-E-driven expression of a variety of factors dealing with folding stress in the periplasm and OMP assembly. Required for basal and stress-induced degradation of RseA. {ECO 0000269|PubMed 10500101, ECO 0000269|PubMed 11442831, ECO 0000269|PubMed 12183368, ECO 0000269|PubMed 12183369, ECO 0000269|PubMed 12679035, ECO 0000269|PubMed 17360428, ECO 0000269|PubMed 17938245, ECO 0000269|PubMed 18945679, ECO 0000269|PubMed 19695325, ECO 0000269|PubMed 19706448}. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_component GO:0071575 integral component of external side of plasma membrane; IMP:EcoliWiki. # GO_function GO:0004252 serine-type endopeptidase activity; IMP:EcoCyc. # GO_function GO:0008233 peptidase activity; IMP:EcoliWiki. # GO_function GO:0008236 serine-type peptidase activity; IMP:EcoliWiki. # GO_process GO:0006508 proteolysis; IDA:EcoliWiki. # GO_process GO:0071218 cellular response to misfolded protein; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0008233 peptidase activity # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # Gene3D 2.30.42.10 -; 1. # INTERACTION DEGS_ECOLI P0AFX7 rseA; NbExp=4; IntAct=EBI-1132101, EBI-1117560; # IntAct P0AEE3 3 # InterPro IPR001478 PDZ # InterPro IPR001940 Peptidase_S1C # InterPro IPR009003 Peptidase_S1_PA # InterPro IPR011783 Pept_S1C_DegS # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # MISCELLANEOUS DEGS_ECOLI Regulated intramembrane proteolysis (RIP) occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. A membrane-spanning regulatory substrate protein is first cut extracytoplasmically (site-1 protease, S1P, this enzyme), then within the membrane itself (site-2 protease, S2P), while cytoplasmic proteases finish degrading the regulatory protein, liberating the effector protein. # Organism DEGS_ECOLI Escherichia coli (strain K12) # PATRIC 32121896 VBIEscCol129921_3332 # PDB 1SOT X-ray; 2.30 A; A/B/C=43-355 # PDB 1SOZ X-ray; 2.40 A; A/B/C=43-355 # PDB 1TE0 X-ray; 2.20 A; A/B=37-354 # PDB 1VCW X-ray; 3.05 A; A/B/C=43-355 # PDB 2QF0 X-ray; 2.50 A; A/B/C/D/E/F/G/H/I=27-256 # PDB 2QF3 X-ray; 2.04 A; A/B/C=27-256 # PDB 2QGR X-ray; 2.70 A; A=27-256 # PDB 2R3U X-ray; 2.60 A; A/B/C=43-252 # PDB 2R3Y X-ray; 2.50 A; A/B/C=43-355 # PDB 2RCE X-ray; 2.35 A; A/B/C/D/E/F/G/H/I=27-256 # PDB 3B8J X-ray; 2.51 A; A=27-256 # PDB 3GCN X-ray; 3.00 A; A=27-355 # PDB 3GCO X-ray; 2.80 A; A=27-355 # PDB 3GDS X-ray; 2.85 A; A=27-355 # PDB 3GDU X-ray; 3.00 A; A/B/C=27-355 # PDB 3GDV X-ray; 2.49 A; A/B/C=27-355 # PDB 3LGI X-ray; 1.65 A; A/B/C=27-256 # PDB 3LGT X-ray; 2.68 A; A=27-256 # PDB 3LGU X-ray; 2.46 A; A=27-256 # PDB 3LGV X-ray; 2.73 A; A/B/C/D/E/F/G/H/I=27-256 # PDB 3LGW X-ray; 2.50 A; A=27-256 # PDB 3LGY X-ray; 2.70 A; A=27-256 # PDB 3LH1 X-ray; 2.51 A; A=27-256 # PDB 3LH3 X-ray; 2.35 A; A/B/C/D/E/F/G/H/I=27-256 # PDB 4RQY X-ray; 2.20 A; A/B=37-355 # PDB 4RQZ X-ray; 2.40 A; A/B/C=43-355 # PDB 4RR0 X-ray; 3.05 A; A/B/C=43-355 # PDB 4RR1 X-ray; 2.30 A; A/B/C=43-355 # PIR JC6052 JC6052 # PRINTS PR00834 PROTEASES2C # PROSITE PS50106 PDZ # Pfam PF13180 PDZ_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DEGS_ECOLI Serine endoprotease DegS # RefSeq NP_417702 NC_000913.3 # RefSeq WP_000497723 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase S1C family. {ECO 0000305}. # SIMILARITY Contains 1 PDZ (DHR) domain. {ECO:0000255|PROSITE- ProRule PRU00143}. # SMART SM00228 PDZ # SUBCELLULAR LOCATION DEGS_ECOLI Cell inner membrane {ECO 0000305|PubMed 11442831}; Single-pass membrane protein {ECO 0000305|PubMed 11442831}. Note=It is unclear how this protein is anchored to the inner membrane, programs predict a signal sequence, but replacing the N-terminal 26 residues with a known signal sequence gives a protein unable to fully complement a disruption mutant. {ECO 0000269|PubMed 11442831}. # SUBUNIT DEGS_ECOLI Homotrimer. {ECO 0000269|PubMed 12679035, ECO 0000269|PubMed 15137941, ECO 0000269|PubMed 15225661, ECO 0000269|PubMed 17938245, ECO 0000269|PubMed 17981123, ECO 0000269|PubMed 19836340, ECO 0000269|PubMed 20739286}. # SUPFAM SSF50156 SSF50156 # SUPFAM SSF50494 SSF50494 # TIGRFAMs TIGR02038 protease_degS # eggNOG COG0265 LUCA # eggNOG ENOG4105C0H Bacteria BLAST swissprot:DEGS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DEGS_ECOLI BioCyc ECOL316407:JW3204-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3204-MONOMER BioCyc EcoCyc:EG11652-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11652-MONOMER BioCyc MetaCyc:EG11652-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11652-MONOMER COG COG0265 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0265 DIP DIP-39580N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-39580N DOI 10.1007/BF00423133 http://dx.doi.org/10.1007/BF00423133 DOI 10.1016/S0092-8674(03)00203-4 http://dx.doi.org/10.1016/S0092-8674(03)00203-4 DOI 10.1016/S0092-8674(04)00454-4 http://dx.doi.org/10.1016/S0092-8674(04)00454-4 DOI 10.1016/j.cell.2007.08.044 http://dx.doi.org/10.1016/j.cell.2007.08.044 DOI 10.1016/j.febslet.2004.06.012 http://dx.doi.org/10.1016/j.febslet.2004.06.012 DOI 10.1016/j.resmic.2009.07.012 http://dx.doi.org/10.1016/j.resmic.2009.07.012 DOI 10.1016/j.str.2009.07.017 http://dx.doi.org/10.1016/j.str.2009.07.017 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2001.02475.x http://dx.doi.org/10.1046/j.1365-2958.2001.02475.x DOI 10.1073/pnas.0611567104 http://dx.doi.org/10.1073/pnas.0611567104 DOI 10.1073/pnas.0903289106 http://dx.doi.org/10.1073/pnas.0903289106 DOI 10.1073/pnas.1019277108 http://dx.doi.org/10.1073/pnas.1019277108 DOI 10.1074/jbc.M110.135541 http://dx.doi.org/10.1074/jbc.M110.135541 DOI 10.1074/jbc.M806603200 http://dx.doi.org/10.1074/jbc.M806603200 DOI 10.1101/gad.1002302 http://dx.doi.org/10.1101/gad.1002302 DOI 10.1101/gad.1008902 http://dx.doi.org/10.1101/gad.1008902 DOI 10.1101/gad.13.18.2449 http://dx.doi.org/10.1101/gad.13.18.2449 DOI 10.1101/gad.445307 http://dx.doi.org/10.1101/gad.445307 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.21.107 http://www.genome.jp/dbget-bin/www_bget?EC:3.4.21.107 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M24777 http://www.ebi.ac.uk/ena/data/view/M24777 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U15661 http://www.ebi.ac.uk/ena/data/view/U15661 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL U32495 http://www.ebi.ac.uk/ena/data/view/U32495 ENZYME 3.4.21.107 http://enzyme.expasy.org/EC/3.4.21.107 EchoBASE EB1605 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1605 EcoGene EG11652 http://www.ecogene.org/geneInfo.php?eg_id=EG11652 EnsemblBacteria AAC76267 http://www.ensemblgenomes.org/id/AAC76267 EnsemblBacteria AAC76267 http://www.ensemblgenomes.org/id/AAC76267 EnsemblBacteria BAE77278 http://www.ensemblgenomes.org/id/BAE77278 EnsemblBacteria BAE77278 http://www.ensemblgenomes.org/id/BAE77278 EnsemblBacteria BAE77278 http://www.ensemblgenomes.org/id/BAE77278 EnsemblBacteria b3235 http://www.ensemblgenomes.org/id/b3235 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_component GO:0071575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071575 GO_function GO:0004252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004252 GO_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GO_function GO:0008236 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008236 GO_process GO:0006508 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006508 GO_process GO:0071218 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071218 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 2.30.42.10 http://www.cathdb.info/version/latest/superfamily/2.30.42.10 GeneID 947865 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947865 HOGENOM HOG000223641 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000223641&db=HOGENOM6 InParanoid P0AEE3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEE3 IntAct P0AEE3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEE3* IntEnz 3.4.21.107 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.21.107 InterPro IPR001478 http://www.ebi.ac.uk/interpro/entry/IPR001478 InterPro IPR001940 http://www.ebi.ac.uk/interpro/entry/IPR001940 InterPro IPR009003 http://www.ebi.ac.uk/interpro/entry/IPR009003 InterPro IPR011783 http://www.ebi.ac.uk/interpro/entry/IPR011783 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW3204 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3204 KEGG_Gene eco:b3235 http://www.genome.jp/dbget-bin/www_bget?eco:b3235 KEGG_Orthology KO:K04691 http://www.genome.jp/dbget-bin/www_bget?KO:K04691 OMA VYNQAND http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VYNQAND PDB 1SOT http://www.ebi.ac.uk/pdbe-srv/view/entry/1SOT PDB 1SOZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1SOZ PDB 1TE0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1TE0 PDB 1VCW http://www.ebi.ac.uk/pdbe-srv/view/entry/1VCW PDB 2QF0 http://www.ebi.ac.uk/pdbe-srv/view/entry/2QF0 PDB 2QF3 http://www.ebi.ac.uk/pdbe-srv/view/entry/2QF3 PDB 2QGR http://www.ebi.ac.uk/pdbe-srv/view/entry/2QGR PDB 2R3U http://www.ebi.ac.uk/pdbe-srv/view/entry/2R3U PDB 2R3Y http://www.ebi.ac.uk/pdbe-srv/view/entry/2R3Y PDB 2RCE http://www.ebi.ac.uk/pdbe-srv/view/entry/2RCE PDB 3B8J http://www.ebi.ac.uk/pdbe-srv/view/entry/3B8J PDB 3GCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3GCN PDB 3GCO http://www.ebi.ac.uk/pdbe-srv/view/entry/3GCO PDB 3GDS http://www.ebi.ac.uk/pdbe-srv/view/entry/3GDS PDB 3GDU http://www.ebi.ac.uk/pdbe-srv/view/entry/3GDU PDB 3GDV http://www.ebi.ac.uk/pdbe-srv/view/entry/3GDV PDB 3LGI http://www.ebi.ac.uk/pdbe-srv/view/entry/3LGI PDB 3LGT http://www.ebi.ac.uk/pdbe-srv/view/entry/3LGT PDB 3LGU http://www.ebi.ac.uk/pdbe-srv/view/entry/3LGU PDB 3LGV http://www.ebi.ac.uk/pdbe-srv/view/entry/3LGV PDB 3LGW http://www.ebi.ac.uk/pdbe-srv/view/entry/3LGW PDB 3LGY http://www.ebi.ac.uk/pdbe-srv/view/entry/3LGY PDB 3LH1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3LH1 PDB 3LH3 http://www.ebi.ac.uk/pdbe-srv/view/entry/3LH3 PDB 4RQY http://www.ebi.ac.uk/pdbe-srv/view/entry/4RQY PDB 4RQZ http://www.ebi.ac.uk/pdbe-srv/view/entry/4RQZ PDB 4RR0 http://www.ebi.ac.uk/pdbe-srv/view/entry/4RR0 PDB 4RR1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4RR1 PDBsum 1SOT http://www.ebi.ac.uk/pdbsum/1SOT PDBsum 1SOZ http://www.ebi.ac.uk/pdbsum/1SOZ PDBsum 1TE0 http://www.ebi.ac.uk/pdbsum/1TE0 PDBsum 1VCW http://www.ebi.ac.uk/pdbsum/1VCW PDBsum 2QF0 http://www.ebi.ac.uk/pdbsum/2QF0 PDBsum 2QF3 http://www.ebi.ac.uk/pdbsum/2QF3 PDBsum 2QGR http://www.ebi.ac.uk/pdbsum/2QGR PDBsum 2R3U http://www.ebi.ac.uk/pdbsum/2R3U PDBsum 2R3Y http://www.ebi.ac.uk/pdbsum/2R3Y PDBsum 2RCE http://www.ebi.ac.uk/pdbsum/2RCE PDBsum 3B8J http://www.ebi.ac.uk/pdbsum/3B8J PDBsum 3GCN http://www.ebi.ac.uk/pdbsum/3GCN PDBsum 3GCO http://www.ebi.ac.uk/pdbsum/3GCO PDBsum 3GDS http://www.ebi.ac.uk/pdbsum/3GDS PDBsum 3GDU http://www.ebi.ac.uk/pdbsum/3GDU PDBsum 3GDV http://www.ebi.ac.uk/pdbsum/3GDV PDBsum 3LGI http://www.ebi.ac.uk/pdbsum/3LGI PDBsum 3LGT http://www.ebi.ac.uk/pdbsum/3LGT PDBsum 3LGU http://www.ebi.ac.uk/pdbsum/3LGU PDBsum 3LGV http://www.ebi.ac.uk/pdbsum/3LGV PDBsum 3LGW http://www.ebi.ac.uk/pdbsum/3LGW PDBsum 3LGY http://www.ebi.ac.uk/pdbsum/3LGY PDBsum 3LH1 http://www.ebi.ac.uk/pdbsum/3LH1 PDBsum 3LH3 http://www.ebi.ac.uk/pdbsum/3LH3 PDBsum 4RQY http://www.ebi.ac.uk/pdbsum/4RQY PDBsum 4RQZ http://www.ebi.ac.uk/pdbsum/4RQZ PDBsum 4RR0 http://www.ebi.ac.uk/pdbsum/4RR0 PDBsum 4RR1 http://www.ebi.ac.uk/pdbsum/4RR1 PRINTS PR00834 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00834 PROSITE PS50106 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50106 PSORT swissprot:DEGS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DEGS_ECOLI PSORT-B swissprot:DEGS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DEGS_ECOLI PSORT2 swissprot:DEGS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DEGS_ECOLI Pfam PF13180 http://pfam.xfam.org/family/PF13180 Phobius swissprot:DEGS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DEGS_ECOLI PhylomeDB P0AEE3 http://phylomedb.org/?seqid=P0AEE3 ProteinModelPortal P0AEE3 http://www.proteinmodelportal.org/query/uniprot/P0AEE3 PubMed 10500101 http://www.ncbi.nlm.nih.gov/pubmed/10500101 PubMed 11442831 http://www.ncbi.nlm.nih.gov/pubmed/11442831 PubMed 12183368 http://www.ncbi.nlm.nih.gov/pubmed/12183368 PubMed 12183369 http://www.ncbi.nlm.nih.gov/pubmed/12183369 PubMed 12679035 http://www.ncbi.nlm.nih.gov/pubmed/12679035 PubMed 15137941 http://www.ncbi.nlm.nih.gov/pubmed/15137941 PubMed 15225661 http://www.ncbi.nlm.nih.gov/pubmed/15225661 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17360428 http://www.ncbi.nlm.nih.gov/pubmed/17360428 PubMed 17938245 http://www.ncbi.nlm.nih.gov/pubmed/17938245 PubMed 17981123 http://www.ncbi.nlm.nih.gov/pubmed/17981123 PubMed 18945679 http://www.ncbi.nlm.nih.gov/pubmed/18945679 PubMed 19695325 http://www.ncbi.nlm.nih.gov/pubmed/19695325 PubMed 19706448 http://www.ncbi.nlm.nih.gov/pubmed/19706448 PubMed 19836340 http://www.ncbi.nlm.nih.gov/pubmed/19836340 PubMed 20739286 http://www.ncbi.nlm.nih.gov/pubmed/20739286 PubMed 21245315 http://www.ncbi.nlm.nih.gov/pubmed/21245315 PubMed 3322223 http://www.ncbi.nlm.nih.gov/pubmed/3322223 PubMed 8576051 http://www.ncbi.nlm.nih.gov/pubmed/8576051 PubMed 8576052 http://www.ncbi.nlm.nih.gov/pubmed/8576052 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417702 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417702 RefSeq WP_000497723 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000497723 SMART SM00228 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00228 SMR P0AEE3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEE3 STRING 511145.b3235 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3235&targetmode=cogs STRING COG0265 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0265&targetmode=cogs SUPFAM SSF50156 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50156 SUPFAM SSF50494 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50494 TIGRFAMs TIGR02038 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02038 UniProtKB DEGS_ECOLI http://www.uniprot.org/uniprot/DEGS_ECOLI UniProtKB-AC P0AEE3 http://www.uniprot.org/uniprot/P0AEE3 charge swissprot:DEGS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DEGS_ECOLI eggNOG COG0265 http://eggnogapi.embl.de/nog_data/html/tree/COG0265 eggNOG ENOG4105C0H http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C0H epestfind swissprot:DEGS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DEGS_ECOLI garnier swissprot:DEGS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DEGS_ECOLI helixturnhelix swissprot:DEGS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DEGS_ECOLI hmoment swissprot:DEGS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DEGS_ECOLI iep swissprot:DEGS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DEGS_ECOLI inforesidue swissprot:DEGS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DEGS_ECOLI octanol swissprot:DEGS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DEGS_ECOLI pepcoil swissprot:DEGS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DEGS_ECOLI pepdigest swissprot:DEGS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DEGS_ECOLI pepinfo swissprot:DEGS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DEGS_ECOLI pepnet swissprot:DEGS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DEGS_ECOLI pepstats swissprot:DEGS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DEGS_ECOLI pepwheel swissprot:DEGS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DEGS_ECOLI pepwindow swissprot:DEGS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DEGS_ECOLI sigcleave swissprot:DEGS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DEGS_ECOLI ## Database ID URL or Descriptions # BioGrid 4262259 8 # CAUTION Could be the product of a pseudogene. There seems to be a natural frameshift that produces two separate ORFs. {ECO 0000305}. # CDD cd06174 MFS # EcoGene EG13527 ygaY # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0055085 transmembrane transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0055085 transmembrane transport # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # Organism YGAY_ECOLI Escherichia coli (strain K12) # PATRIC 48664767 VBIEscCol107702_2708 # PIR A65048 A65048 # PIR B65048 B65048 # PROSITE PS50850 MFS # Pfam PF07690 MFS_1; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGAY_ECOLI Putative uncharacterized transporter YgaY # SEQUENCE CAUTION Sequence=BAE76783.1; Type=Frameshift; Positions=88; Evidence={ECO:0000305}; Sequence=U00096; Type=Frameshift; Positions=88; Evidence={ECO 0000305}; # SIMILARITY Belongs to the major facilitator superfamily. {ECO 0000305}. # SUBCELLULAR LOCATION YGAY_ECOLI Cell inner membrane {ECO 0000305}; Multi- pass membrane protein {ECO 0000305}. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.36 the major facilitator superfamily (mfs) BLAST swissprot:YGAY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGAY_ECOLI BioCyc ECOL316407:JW2655-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2655-MONOMER BioCyc EcoCyc:G7404-MONOMER http://biocyc.org/getid?id=EcoCyc:G7404-MONOMER BioCyc EcoCyc:YGAY-MONOMER http://biocyc.org/getid?id=EcoCyc:YGAY-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG13527 http://www.ecogene.org/geneInfo.php?eg_id=EG13527 EnsemblBacteria BAE76783 http://www.ensemblgenomes.org/id/BAE76783 EnsemblBacteria BAE76783 http://www.ensemblgenomes.org/id/BAE76783 EnsemblBacteria BAE76783 http://www.ensemblgenomes.org/id/BAE76783 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 InParanoid P76628 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76628 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Gene ecj:JW2655 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2655 OMA AQLGYAC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AQLGYAC PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:YGAY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGAY_ECOLI PSORT-B swissprot:YGAY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGAY_ECOLI PSORT2 swissprot:YGAY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGAY_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:YGAY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGAY_ECOLI PhylomeDB P76628 http://phylomedb.org/?seqid=P76628 ProteinModelPortal P76628 http://www.proteinmodelportal.org/query/uniprot/P76628 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 STRING 316407.85675521 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85675521&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.36 http://www.tcdb.org/search/result.php?tc=2.A.1.36 UniProtKB YGAY_ECOLI http://www.uniprot.org/uniprot/YGAY_ECOLI UniProtKB-AC P76628 http://www.uniprot.org/uniprot/P76628 charge swissprot:YGAY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGAY_ECOLI epestfind swissprot:YGAY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGAY_ECOLI garnier swissprot:YGAY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGAY_ECOLI helixturnhelix swissprot:YGAY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGAY_ECOLI hmoment swissprot:YGAY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGAY_ECOLI iep swissprot:YGAY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGAY_ECOLI inforesidue swissprot:YGAY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGAY_ECOLI octanol swissprot:YGAY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGAY_ECOLI pepcoil swissprot:YGAY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGAY_ECOLI pepdigest swissprot:YGAY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGAY_ECOLI pepinfo swissprot:YGAY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGAY_ECOLI pepnet swissprot:YGAY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGAY_ECOLI pepstats swissprot:YGAY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGAY_ECOLI pepwheel swissprot:YGAY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGAY_ECOLI pepwindow swissprot:YGAY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGAY_ECOLI sigcleave swissprot:YGAY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGAY_ECOLI ## Database ID URL or Descriptions # BioGrid 4262120 14 # EcoGene EG10815 rbsB # FUNCTION RBSB_ECOLI Part of the ABC transporter complex RbsABC involved in ribose import. Binds ribose. Also serves as the primary chemoreceptor for chemotaxis. {ECO 0000269|PubMed 25533465, ECO 0000269|PubMed 4608146, ECO 0000269|PubMed 6327617, ECO 0000269|PubMed 7982928}. # GO_component GO:0005886 plasma membrane; IBA:GO_Central. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_component GO:0016021 integral component of membrane; IBA:GO_Central. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0015145 monosaccharide transmembrane transporter activity; IBA:GO_Central. # GO_process GO:0006935 chemotaxis; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0040011 locomotion # IntAct P02925 16 # InterPro IPR025997 SBP_2_dom # InterPro IPR028082 Peripla_BP_I # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00212 Ribose transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # KEGG_Pathway ko02030 Bacterial chemotaxis # Organism RBSB_ECOLI Escherichia coli (strain K12) # PATRIC 32123001 VBIEscCol129921_3876 # PDB 1BA2 X-ray; 2.10 A; A/B=26-296 # PDB 1DBP X-ray; 2.20 A; A=26-296 # PDB 1DRJ X-ray; 2.50 A; A=26-296 # PDB 1DRK X-ray; 2.00 A; A=26-296 # PDB 1URP X-ray; 2.30 A; A/B/C/D=26-296 # PDB 2DRI X-ray; 1.60 A; A=26-296 # PDB 2GX6 X-ray; 1.97 A; A=26-296 # PIR A03425 JGECR # Pfam PF13407 Peripla_BP_4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Ribose import binding protein RbsB {ECO 0000305} # RefSeq NP_418207 NC_000913.3 # RefSeq WP_001056271 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial solute-binding protein 2 family. {ECO 0000305}. # SUBCELLULAR LOCATION RBSB_ECOLI Periplasm {ECO 0000269|PubMed 1583688}. # SUBUNIT The complex is composed of an ATP-binding protein (RbsA), two transmembrane proteins (RbsC) and a solute-binding protein (RbsB). {ECO:0000269|PubMed 25533465}. # SUPFAM SSF53822 SSF53822 # TCDB 3.A.1.2 the atp-binding cassette (abc) superfamily # eggNOG COG1879 LUCA # eggNOG ENOG4105E9V Bacteria BLAST swissprot:RBSB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RBSB_ECOLI BioCyc ECOL316407:JW3730-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3730-MONOMER BioCyc EcoCyc:RBSB-MONOMER http://biocyc.org/getid?id=EcoCyc:RBSB-MONOMER BioCyc MetaCyc:RBSB-MONOMER http://biocyc.org/getid?id=MetaCyc:RBSB-MONOMER COG COG1879 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1879 DIP DIP-10641N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10641N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1006/jmbi.1998.1785 http://dx.doi.org/10.1006/jmbi.1998.1785 DOI 10.1016/0022-2836(92)91033-L http://dx.doi.org/10.1016/0022-2836(92)91033-L DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M114.621573 http://dx.doi.org/10.1074/jbc.M114.621573 DOI 10.1111/j.1365-2958.1996.tb02652.x http://dx.doi.org/10.1111/j.1365-2958.1996.tb02652.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K00511 http://www.ebi.ac.uk/ena/data/view/K00511 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M13169 http://www.ebi.ac.uk/ena/data/view/M13169 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0808 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0808 EcoGene EG10815 http://www.ecogene.org/geneInfo.php?eg_id=EG10815 EnsemblBacteria AAC76774 http://www.ensemblgenomes.org/id/AAC76774 EnsemblBacteria AAC76774 http://www.ensemblgenomes.org/id/AAC76774 EnsemblBacteria BAE77537 http://www.ensemblgenomes.org/id/BAE77537 EnsemblBacteria BAE77537 http://www.ensemblgenomes.org/id/BAE77537 EnsemblBacteria BAE77537 http://www.ensemblgenomes.org/id/BAE77537 EnsemblBacteria b3751 http://www.ensemblgenomes.org/id/b3751 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0015145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015145 GO_process GO:0006935 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006935 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0040011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011 GeneID 948261 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948261 HOGENOM HOG000212345 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000212345&db=HOGENOM6 InParanoid P02925 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P02925 IntAct P02925 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P02925* InterPro IPR025997 http://www.ebi.ac.uk/interpro/entry/IPR025997 InterPro IPR028082 http://www.ebi.ac.uk/interpro/entry/IPR028082 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3730 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3730 KEGG_Gene eco:b3751 http://www.genome.jp/dbget-bin/www_bget?eco:b3751 KEGG_Orthology KO:K10439 http://www.genome.jp/dbget-bin/www_bget?KO:K10439 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 KEGG_Pathway ko02030 http://www.genome.jp/kegg-bin/show_pathway?ko02030 MINT MINT-1244685 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1244685 OMA NAIRMAN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NAIRMAN PDB 1BA2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1BA2 PDB 1DBP http://www.ebi.ac.uk/pdbe-srv/view/entry/1DBP PDB 1DRJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1DRJ PDB 1DRK http://www.ebi.ac.uk/pdbe-srv/view/entry/1DRK PDB 1URP http://www.ebi.ac.uk/pdbe-srv/view/entry/1URP PDB 2DRI http://www.ebi.ac.uk/pdbe-srv/view/entry/2DRI PDB 2GX6 http://www.ebi.ac.uk/pdbe-srv/view/entry/2GX6 PDBsum 1BA2 http://www.ebi.ac.uk/pdbsum/1BA2 PDBsum 1DBP http://www.ebi.ac.uk/pdbsum/1DBP PDBsum 1DRJ http://www.ebi.ac.uk/pdbsum/1DRJ PDBsum 1DRK http://www.ebi.ac.uk/pdbsum/1DRK PDBsum 1URP http://www.ebi.ac.uk/pdbsum/1URP PDBsum 2DRI http://www.ebi.ac.uk/pdbsum/2DRI PDBsum 2GX6 http://www.ebi.ac.uk/pdbsum/2GX6 PSORT swissprot:RBSB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RBSB_ECOLI PSORT-B swissprot:RBSB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RBSB_ECOLI PSORT2 swissprot:RBSB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RBSB_ECOLI Pfam PF13407 http://pfam.xfam.org/family/PF13407 Phobius swissprot:RBSB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RBSB_ECOLI PhylomeDB P02925 http://phylomedb.org/?seqid=P02925 ProteinModelPortal P02925 http://www.proteinmodelportal.org/query/uniprot/P02925 PubMed 1583688 http://www.ncbi.nlm.nih.gov/pubmed/1583688 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 25533465 http://www.ncbi.nlm.nih.gov/pubmed/25533465 PubMed 3011793 http://www.ncbi.nlm.nih.gov/pubmed/3011793 PubMed 3011794 http://www.ncbi.nlm.nih.gov/pubmed/3011794 PubMed 4608146 http://www.ncbi.nlm.nih.gov/pubmed/4608146 PubMed 6313683 http://www.ncbi.nlm.nih.gov/pubmed/6313683 PubMed 6327617 http://www.ncbi.nlm.nih.gov/pubmed/6327617 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 7982928 http://www.ncbi.nlm.nih.gov/pubmed/7982928 PubMed 8899705 http://www.ncbi.nlm.nih.gov/pubmed/8899705 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9641984 http://www.ncbi.nlm.nih.gov/pubmed/9641984 RefSeq NP_418207 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418207 RefSeq WP_001056271 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001056271 SMR P02925 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P02925 STRING 511145.b3751 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3751&targetmode=cogs STRING COG1879 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1879&targetmode=cogs SUPFAM SSF53822 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822 SWISS-2DPAGE P02925 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P02925 TCDB 3.A.1.2 http://www.tcdb.org/search/result.php?tc=3.A.1.2 UniProtKB RBSB_ECOLI http://www.uniprot.org/uniprot/RBSB_ECOLI UniProtKB-AC P02925 http://www.uniprot.org/uniprot/P02925 charge swissprot:RBSB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RBSB_ECOLI eggNOG COG1879 http://eggnogapi.embl.de/nog_data/html/tree/COG1879 eggNOG ENOG4105E9V http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E9V epestfind swissprot:RBSB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RBSB_ECOLI garnier swissprot:RBSB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RBSB_ECOLI helixturnhelix swissprot:RBSB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RBSB_ECOLI hmoment swissprot:RBSB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RBSB_ECOLI iep swissprot:RBSB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RBSB_ECOLI inforesidue swissprot:RBSB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RBSB_ECOLI octanol swissprot:RBSB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RBSB_ECOLI pepcoil swissprot:RBSB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RBSB_ECOLI pepdigest swissprot:RBSB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RBSB_ECOLI pepinfo swissprot:RBSB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RBSB_ECOLI pepnet swissprot:RBSB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RBSB_ECOLI pepstats swissprot:RBSB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RBSB_ECOLI pepwheel swissprot:RBSB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RBSB_ECOLI pepwindow swissprot:RBSB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RBSB_ECOLI sigcleave swissprot:RBSB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RBSB_ECOLI ## Database ID URL or Descriptions # BioGrid 4259620 172 # EcoGene EG11980 rfbX # FUNCTION RFBX_ECOLI May be involved in the translocation process of the nascent O-polysaccharide molecules and/or its ligation to lipid A core units. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006810 transport; IBA:GO_Central. # GO_process GO:0006974 cellular response to DNA damage stimulus; IMP:EcoCyc. # GO_process GO:0009243 O antigen biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0046677 response to antibiotic; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006810 transport # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # InterPro IPR002797 Polysacc_synth # Organism RFBX_ECOLI Escherichia coli (strain K12) # PATHWAY RFBX_ECOLI Bacterial outer membrane biogenesis; LPS O-antigen biosynthesis. # PATRIC 32119407 VBIEscCol129921_2113 # PIR D64969 D64969 # Pfam PF01943 Polysacc_synt # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RFBX_ECOLI Putative O-antigen transporter # RefSeq NP_416541 NC_000913.3 # RefSeq WP_001393538 NZ_LN832404.1 # SIMILARITY Belongs to the polysaccharide synthase family. {ECO 0000305}. # SUBCELLULAR LOCATION RFBX_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.66.2 the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily # eggNOG COG2244 LUCA # eggNOG ENOG4105ER6 Bacteria BLAST swissprot:RFBX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RFBX_ECOLI BioCyc ECOL316407:JW2022-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2022-MONOMER BioCyc EcoCyc:RFBX-MONOMER http://biocyc.org/getid?id=EcoCyc:RFBX-MONOMER BioCyc MetaCyc:RFBX-MONOMER http://biocyc.org/getid?id=MetaCyc:RFBX-MONOMER COG COG2244 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2244 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U03041 http://www.ebi.ac.uk/ena/data/view/U03041 EMBL U09876 http://www.ebi.ac.uk/ena/data/view/U09876 EchoBASE EB1923 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1923 EcoGene EG11980 http://www.ecogene.org/geneInfo.php?eg_id=EG11980 EnsemblBacteria AAC75098 http://www.ensemblgenomes.org/id/AAC75098 EnsemblBacteria AAC75098 http://www.ensemblgenomes.org/id/AAC75098 EnsemblBacteria BAA15879 http://www.ensemblgenomes.org/id/BAA15879 EnsemblBacteria BAA15879 http://www.ensemblgenomes.org/id/BAA15879 EnsemblBacteria BAA15879 http://www.ensemblgenomes.org/id/BAA15879 EnsemblBacteria b2037 http://www.ensemblgenomes.org/id/b2037 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0009243 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009243 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 946557 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946557 HOGENOM HOG000176959 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000176959&db=HOGENOM6 InParanoid P37746 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37746 InterPro IPR002797 http://www.ebi.ac.uk/interpro/entry/IPR002797 KEGG_Gene ecj:JW2022 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2022 KEGG_Gene eco:b2037 http://www.genome.jp/dbget-bin/www_bget?eco:b2037 KEGG_Orthology KO:K03328 http://www.genome.jp/dbget-bin/www_bget?KO:K03328 OMA IRTQYLI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IRTQYLI PSORT swissprot:RFBX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RFBX_ECOLI PSORT-B swissprot:RFBX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RFBX_ECOLI PSORT2 swissprot:RFBX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RFBX_ECOLI Pfam PF01943 http://pfam.xfam.org/family/PF01943 Phobius swissprot:RFBX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RFBX_ECOLI PhylomeDB P37746 http://phylomedb.org/?seqid=P37746 ProteinModelPortal P37746 http://www.proteinmodelportal.org/query/uniprot/P37746 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7517390 http://www.ncbi.nlm.nih.gov/pubmed/7517390 PubMed 7517391 http://www.ncbi.nlm.nih.gov/pubmed/7517391 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416541 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416541 RefSeq WP_001393538 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001393538 STRING 511145.b2037 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2037&targetmode=cogs STRING COG2244 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2244&targetmode=cogs TCDB 2.A.66.2 http://www.tcdb.org/search/result.php?tc=2.A.66.2 UniProtKB RFBX_ECOLI http://www.uniprot.org/uniprot/RFBX_ECOLI UniProtKB-AC P37746 http://www.uniprot.org/uniprot/P37746 charge swissprot:RFBX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RFBX_ECOLI eggNOG COG2244 http://eggnogapi.embl.de/nog_data/html/tree/COG2244 eggNOG ENOG4105ER6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ER6 epestfind swissprot:RFBX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RFBX_ECOLI garnier swissprot:RFBX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RFBX_ECOLI helixturnhelix swissprot:RFBX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RFBX_ECOLI hmoment swissprot:RFBX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RFBX_ECOLI iep swissprot:RFBX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RFBX_ECOLI inforesidue swissprot:RFBX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RFBX_ECOLI octanol swissprot:RFBX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RFBX_ECOLI pepcoil swissprot:RFBX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RFBX_ECOLI pepdigest swissprot:RFBX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RFBX_ECOLI pepinfo swissprot:RFBX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RFBX_ECOLI pepnet swissprot:RFBX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RFBX_ECOLI pepstats swissprot:RFBX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RFBX_ECOLI pepwheel swissprot:RFBX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RFBX_ECOLI pepwindow swissprot:RFBX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RFBX_ECOLI sigcleave swissprot:RFBX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RFBX_ECOLI ## Database ID URL or Descriptions # BioGrid 4259272 84 # EcoGene EG12786 yhbQ # GO_process GO:0090305 nucleic acid phosphodiester bond hydrolysis; IEA:UniProtKB-HAMAP. # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # HAMAP MF_01029 UPF0213 # IntAct P45472 13 # InterPro IPR000305 GIY-YIG_SF # InterPro IPR022992 UPF0213_GIY-YIG_endonuc # Organism YHBQ_ECOLI Escherichia coli (strain K12) # PATRIC 32121728 VBIEscCol129921_3250 # PIR G65105 G65105 # PROSITE PS50164 GIY_YIG # Pfam PF01541 GIY-YIG # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UPF0213 protein YhbQ {ECO:0000255|HAMAP-Rule MF_01029} # RefSeq NP_417624 NC_000913.3 # RefSeq WP_000189333 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0213 family. {ECO:0000255|HAMAP- Rule MF_01029}. # SIMILARITY Contains 1 GIY-YIG domain. {ECO:0000255|HAMAP- Rule MF_01029}. # SMART SM00465 GIYc # SUPFAM SSF82771 SSF82771 # eggNOG COG2827 LUCA # eggNOG ENOG41082IR Bacteria BLAST swissprot:YHBQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHBQ_ECOLI BioCyc ECOL316407:JW3124-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3124-MONOMER BioCyc EcoCyc:G7649-MONOMER http://biocyc.org/getid?id=EcoCyc:G7649-MONOMER BioCyc MetaCyc:G7649-MONOMER http://biocyc.org/getid?id=MetaCyc:G7649-MONOMER COG COG2827 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2827 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2639 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2639 EcoGene EG12786 http://www.ecogene.org/geneInfo.php?eg_id=EG12786 EnsemblBacteria AAC76189 http://www.ensemblgenomes.org/id/AAC76189 EnsemblBacteria AAC76189 http://www.ensemblgenomes.org/id/AAC76189 EnsemblBacteria BAE77201 http://www.ensemblgenomes.org/id/BAE77201 EnsemblBacteria BAE77201 http://www.ensemblgenomes.org/id/BAE77201 EnsemblBacteria BAE77201 http://www.ensemblgenomes.org/id/BAE77201 EnsemblBacteria b3155 http://www.ensemblgenomes.org/id/b3155 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0090305 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090305 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 947671 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947671 HAMAP MF_01029 http://hamap.expasy.org/unirule/MF_01029 HOGENOM HOG000285485 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000285485&db=HOGENOM6 InParanoid P45472 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45472 IntAct P45472 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45472* InterPro IPR000305 http://www.ebi.ac.uk/interpro/entry/IPR000305 InterPro IPR022992 http://www.ebi.ac.uk/interpro/entry/IPR022992 KEGG_Gene ecj:JW3124 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3124 KEGG_Gene eco:b3155 http://www.genome.jp/dbget-bin/www_bget?eco:b3155 KEGG_Orthology KO:K07461 http://www.genome.jp/dbget-bin/www_bget?KO:K07461 OMA ALKWEYR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ALKWEYR PROSITE PS50164 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50164 PSORT swissprot:YHBQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHBQ_ECOLI PSORT-B swissprot:YHBQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHBQ_ECOLI PSORT2 swissprot:YHBQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHBQ_ECOLI Pfam PF01541 http://pfam.xfam.org/family/PF01541 Phobius swissprot:YHBQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHBQ_ECOLI PhylomeDB P45472 http://phylomedb.org/?seqid=P45472 ProteinModelPortal P45472 http://www.proteinmodelportal.org/query/uniprot/P45472 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417624 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417624 RefSeq WP_000189333 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000189333 SMART SM00465 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00465 SMR P45472 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45472 STRING 511145.b3155 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3155&targetmode=cogs STRING COG2827 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2827&targetmode=cogs SUPFAM SSF82771 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF82771 UniProtKB YHBQ_ECOLI http://www.uniprot.org/uniprot/YHBQ_ECOLI UniProtKB-AC P45472 http://www.uniprot.org/uniprot/P45472 charge swissprot:YHBQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHBQ_ECOLI eggNOG COG2827 http://eggnogapi.embl.de/nog_data/html/tree/COG2827 eggNOG ENOG41082IR http://eggnogapi.embl.de/nog_data/html/tree/ENOG41082IR epestfind swissprot:YHBQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHBQ_ECOLI garnier swissprot:YHBQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHBQ_ECOLI helixturnhelix swissprot:YHBQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHBQ_ECOLI hmoment swissprot:YHBQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHBQ_ECOLI iep swissprot:YHBQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHBQ_ECOLI inforesidue swissprot:YHBQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHBQ_ECOLI octanol swissprot:YHBQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHBQ_ECOLI pepcoil swissprot:YHBQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHBQ_ECOLI pepdigest swissprot:YHBQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHBQ_ECOLI pepinfo swissprot:YHBQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHBQ_ECOLI pepnet swissprot:YHBQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHBQ_ECOLI pepstats swissprot:YHBQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHBQ_ECOLI pepwheel swissprot:YHBQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHBQ_ECOLI pepwindow swissprot:YHBQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHBQ_ECOLI sigcleave swissprot:YHBQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHBQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4259911 8 # CATALYTIC ACTIVITY ATP + H(2)O + polar amino acid(Out) = ADP + phosphate + polar amino acid(In). {ECO:0000305|PubMed 9593292}. # EcoGene EG12663 gltL # FUNCTION GLTL_ECOLI Part of the ABC transporter complex GltIJKL involved in glutamate and aspartate uptake. Probably responsible for energy coupling to the transport system. {ECO 0000305|PubMed 9593292}. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IEA:InterPro. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0015426 polar-amino acid-transporting ATPase activity; IEA:UniProtKB-EC. # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.300 -; 1. # IntAct P0AAG3 6 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # InterPro IPR030206 GltL/AatP # InterPro IPR030679 ABC_ATPase_HisP-typ # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00230 Glutamate/aspartate transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism GLTL_ECOLI Escherichia coli (strain K12) # PANTHER PTHR24220:SF317 PTHR24220:SF317 # PATRIC 32116487 VBIEscCol129921_0683 # PIR B64800 B64800 # PIRSF PIRSF039085 ABC_ATPase_HisP # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # Pfam PF00005 ABC_tran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Glutamate/aspartate import ATP-binding protein GltL {ECO 0000305} # RefSeq NP_415185 NC_000913.3 # RefSeq WP_000631384 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA # SUBCELLULAR LOCATION GLTL_ECOLI Cell inner membrane {ECO 0000305|PubMed 9593292}; Peripheral membrane protein {ECO 0000305|PubMed 9593292}. # SUBUNIT The complex is composed of two ATP-binding proteins (GltL), two transmembrane proteins (GltJ and GltK) and a solute- binding protein (GltI). {ECO:0000305|PubMed 9593292}. # SUPFAM SSF52540 SSF52540 # TCDB 3.A.1.3 the atp-binding cassette (abc) superfamily # eggNOG COG1126 LUCA # eggNOG ENOG4105CDA Bacteria BLAST swissprot:GLTL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLTL_ECOLI BioCyc ECOL316407:JW0647-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0647-MONOMER BioCyc EcoCyc:GLTL-MONOMER http://biocyc.org/getid?id=EcoCyc:GLTL-MONOMER BioCyc MetaCyc:GLTL-MONOMER http://biocyc.org/getid?id=MetaCyc:GLTL-MONOMER COG COG1126 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1126 DIP DIP-48246N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48246N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1998.00764.x http://dx.doi.org/10.1046/j.1365-2958.1998.00764.x DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.3.21 {ECO:0000305|PubMed:9593292} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.21 {ECO:0000305|PubMed:9593292} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U10981 http://www.ebi.ac.uk/ena/data/view/U10981 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 ENZYME 3.6.3.21 {ECO:0000305|PubMed:9593292} http://enzyme.expasy.org/EC/3.6.3.21 {ECO:0000305|PubMed:9593292} EchoBASE EB2529 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2529 EcoGene EG12663 http://www.ecogene.org/geneInfo.php?eg_id=EG12663 EnsemblBacteria AAC73753 http://www.ensemblgenomes.org/id/AAC73753 EnsemblBacteria AAC73753 http://www.ensemblgenomes.org/id/AAC73753 EnsemblBacteria BAA35304 http://www.ensemblgenomes.org/id/BAA35304 EnsemblBacteria BAA35304 http://www.ensemblgenomes.org/id/BAA35304 EnsemblBacteria BAA35304 http://www.ensemblgenomes.org/id/BAA35304 EnsemblBacteria b0652 http://www.ensemblgenomes.org/id/b0652 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0015426 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015426 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945254 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945254 InParanoid P0AAG3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAG3 IntAct P0AAG3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAG3* IntEnz 3.6.3.21 {ECO:0000305|PubMed:9593292} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.21 {ECO:0000305|PubMed:9593292} InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR030206 http://www.ebi.ac.uk/interpro/entry/IPR030206 InterPro IPR030679 http://www.ebi.ac.uk/interpro/entry/IPR030679 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0647 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0647 KEGG_Gene eco:b0652 http://www.genome.jp/dbget-bin/www_bget?eco:b0652 KEGG_Orthology KO:K10004 http://www.genome.jp/dbget-bin/www_bget?KO:K10004 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 MINT MINT-1307893 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1307893 OMA VTIARTM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VTIARTM PANTHER PTHR24220:SF317 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24220:SF317 PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:GLTL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLTL_ECOLI PSORT-B swissprot:GLTL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLTL_ECOLI PSORT2 swissprot:GLTL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLTL_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Phobius swissprot:GLTL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLTL_ECOLI PhylomeDB P0AAG3 http://phylomedb.org/?seqid=P0AAG3 ProteinModelPortal P0AAG3 http://www.proteinmodelportal.org/query/uniprot/P0AAG3 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9593292 http://www.ncbi.nlm.nih.gov/pubmed/9593292 RefSeq NP_415185 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415185 RefSeq WP_000631384 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000631384 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P0AAG3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAG3 STRING 511145.b0652 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0652&targetmode=cogs STRING COG1126 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1126&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.3 http://www.tcdb.org/search/result.php?tc=3.A.1.3 UniProtKB GLTL_ECOLI http://www.uniprot.org/uniprot/GLTL_ECOLI UniProtKB-AC P0AAG3 http://www.uniprot.org/uniprot/P0AAG3 charge swissprot:GLTL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLTL_ECOLI eggNOG COG1126 http://eggnogapi.embl.de/nog_data/html/tree/COG1126 eggNOG ENOG4105CDA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CDA epestfind swissprot:GLTL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLTL_ECOLI garnier swissprot:GLTL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLTL_ECOLI helixturnhelix swissprot:GLTL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLTL_ECOLI hmoment swissprot:GLTL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLTL_ECOLI iep swissprot:GLTL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLTL_ECOLI inforesidue swissprot:GLTL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLTL_ECOLI octanol swissprot:GLTL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLTL_ECOLI pepcoil swissprot:GLTL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLTL_ECOLI pepdigest swissprot:GLTL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLTL_ECOLI pepinfo swissprot:GLTL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLTL_ECOLI pepnet swissprot:GLTL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLTL_ECOLI pepstats swissprot:GLTL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLTL_ECOLI pepwheel swissprot:GLTL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLTL_ECOLI pepwindow swissprot:GLTL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLTL_ECOLI sigcleave swissprot:GLTL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLTL_ECOLI ## Database ID URL or Descriptions # BioGrid 4260064 9 # CDD cd06170 LuxR_C_like # DISRUPTION PHENOTYPE No curli production. {ECO:0000269|PubMed 24212724}. # EcoGene EG13410 csgD # FUNCTION CSGD_ECOLI The master regulator for adhesive curli fimbriae expression; necessary for transcription of the csgBAC/ymdA operon. Plays a positive role in biofilm formation. May have the capability to respond to starvation and/or high cell density by activating csgBA transcription. Low-level constitutive expression confers an adherent curli fimbriae-expressing phenotype, up- regulates 10 genes and down-regulates 14 others. {ECO 0000269|PubMed 16513732}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_function GO:0000986 bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:1900190 regulation of single-species biofilm formation; IDA:EcoCyc. # GO_process GO:2000144 positive regulation of DNA-templated transcription, initiation; IMP:EcoCyc. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # INDUCTION CSGD_ECOLI Regulation is very complex. Strongly induced at 28 degrees Celsius (at protein level), transcription regulation requires c-di-GMP, although the mechanism is currently unknown. c- di-GMP levels are stimulated by the diguanylate cyclase YdaM and repressed by the c-di-GMP phosphodiesterase Gmr (YciR) (PubMed 17010156). Transcription directly repressed by MqsA, and indirectly repressed by MqsA via MqsA's repression of rpoS (PubMed 24212724). {ECO 0000269|PubMed 17010156, ECO 0000269|PubMed 24212724}. # IntAct P52106 2 # InterPro IPR000792 Tscrpt_reg_LuxR_C # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR016032 Sig_transdc_resp-reg_C-effctor # KEGG_Brite ko03000 Transcription factors # Organism CSGD_ECOLI Escherichia coli (strain K12) # PATRIC 32117313 VBIEscCol129921_1079 # PIR S70786 S70786 # PRINTS PR00038 HTHLUXR # PROSITE PS00622 HTH_LUXR_1 # PROSITE PS50043 HTH_LUXR_2 # Pfam PF00196 GerE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CSGD_ECOLI CsgBAC operon transcriptional regulatory protein # RefSeq NP_415558 NC_000913.3 # RefSeq WP_000481509 NZ_LN832404.1 # SIMILARITY Contains 1 HTH luxR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00411}. # SMART SM00421 HTH_LUXR # SUBCELLULAR LOCATION CSGD_ECOLI Cell inner membrane {ECO 0000305|PubMed 16513732}; Peripheral membrane protein {ECO 0000305|PubMed 16513732}. Note=In experiments done with low- level constitutively expressed protein. # SUPFAM SSF46894 SSF46894 # eggNOG COG2771 LUCA # eggNOG ENOG41086KC Bacteria BLAST swissprot:CSGD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CSGD_ECOLI BioCyc ECOL316407:JW1023-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1023-MONOMER BioCyc EcoCyc:PD01379 http://biocyc.org/getid?id=EcoCyc:PD01379 COG COG2771 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2771 DIP DIP-9328N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9328N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/srep03186 http://dx.doi.org/10.1038/srep03186 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1995.mmi_18040661.x http://dx.doi.org/10.1111/j.1365-2958.1995.mmi_18040661.x DOI 10.1111/j.1365-2958.2006.05440.x http://dx.doi.org/10.1111/j.1365-2958.2006.05440.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.188.6.2027-2037.2006 http://dx.doi.org/10.1128/JB.188.6.2027-2037.2006 EMBL AF081826 http://www.ebi.ac.uk/ena/data/view/AF081826 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X90754 http://www.ebi.ac.uk/ena/data/view/X90754 EchoBASE EB3186 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3186 EcoGene EG13410 http://www.ecogene.org/geneInfo.php?eg_id=EG13410 EnsemblBacteria AAC74124 http://www.ensemblgenomes.org/id/AAC74124 EnsemblBacteria AAC74124 http://www.ensemblgenomes.org/id/AAC74124 EnsemblBacteria BAA35830 http://www.ensemblgenomes.org/id/BAA35830 EnsemblBacteria BAA35830 http://www.ensemblgenomes.org/id/BAA35830 EnsemblBacteria BAA35830 http://www.ensemblgenomes.org/id/BAA35830 EnsemblBacteria b1040 http://www.ensemblgenomes.org/id/b1040 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0000986 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000986 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:1900190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1900190 GO_process GO:2000144 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000144 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 949119 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949119 HOGENOM HOG000284130 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000284130&db=HOGENOM6 IntAct P52106 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P52106* InterPro IPR000792 http://www.ebi.ac.uk/interpro/entry/IPR000792 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR016032 http://www.ebi.ac.uk/interpro/entry/IPR016032 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW1023 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1023 KEGG_Gene eco:b1040 http://www.genome.jp/dbget-bin/www_bget?eco:b1040 KEGG_Orthology KO:K04333 http://www.genome.jp/dbget-bin/www_bget?KO:K04333 MINT MINT-1293972 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1293972 OMA RKNNNIR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RKNNNIR PRINTS PR00038 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00038 PROSITE PS00622 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00622 PROSITE PS50043 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50043 PSORT swissprot:CSGD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CSGD_ECOLI PSORT-B swissprot:CSGD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CSGD_ECOLI PSORT2 swissprot:CSGD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CSGD_ECOLI Pfam PF00196 http://pfam.xfam.org/family/PF00196 Phobius swissprot:CSGD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CSGD_ECOLI PhylomeDB P52106 http://phylomedb.org/?seqid=P52106 ProteinModelPortal P52106 http://www.proteinmodelportal.org/query/uniprot/P52106 PubMed 16513732 http://www.ncbi.nlm.nih.gov/pubmed/16513732 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17010156 http://www.ncbi.nlm.nih.gov/pubmed/17010156 PubMed 24212724 http://www.ncbi.nlm.nih.gov/pubmed/24212724 PubMed 8817489 http://www.ncbi.nlm.nih.gov/pubmed/8817489 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415558 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415558 RefSeq WP_000481509 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000481509 SMART SM00421 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00421 SMR P52106 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P52106 STRING 511145.b1040 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1040&targetmode=cogs STRING COG2771 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2771&targetmode=cogs SUPFAM SSF46894 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46894 UniProtKB CSGD_ECOLI http://www.uniprot.org/uniprot/CSGD_ECOLI UniProtKB-AC P52106 http://www.uniprot.org/uniprot/P52106 charge swissprot:CSGD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CSGD_ECOLI eggNOG COG2771 http://eggnogapi.embl.de/nog_data/html/tree/COG2771 eggNOG ENOG41086KC http://eggnogapi.embl.de/nog_data/html/tree/ENOG41086KC epestfind swissprot:CSGD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CSGD_ECOLI garnier swissprot:CSGD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CSGD_ECOLI helixturnhelix swissprot:CSGD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CSGD_ECOLI hmoment swissprot:CSGD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CSGD_ECOLI iep swissprot:CSGD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CSGD_ECOLI inforesidue swissprot:CSGD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CSGD_ECOLI octanol swissprot:CSGD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CSGD_ECOLI pepcoil swissprot:CSGD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CSGD_ECOLI pepdigest swissprot:CSGD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CSGD_ECOLI pepinfo swissprot:CSGD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CSGD_ECOLI pepnet swissprot:CSGD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CSGD_ECOLI pepstats swissprot:CSGD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CSGD_ECOLI pepwheel swissprot:CSGD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CSGD_ECOLI pepwindow swissprot:CSGD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CSGD_ECOLI sigcleave swissprot:CSGD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CSGD_ECOLI ## Database ID URL or Descriptions # BioGrid 4261450 183 # CDD cd06174 MFS # EcoGene EG12576 mdtM # FUNCTION MDTM_ECOLI Confers resistance to acriflavine, chloramphenicol, norfloxacin, ethidium bromide and TPP. {ECO 0000269|PubMed 11566977}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015238 drug transmembrane transporter activity; IMP:EcoCyc. # GO_function MDTM_ECOLI GO 0015307 drug proton antiporter activity; IDA EcoCyc. # GO_function MDTM_ECOLI GO 0015385 sodium proton antiporter activity; IDA EcoCyc. # GO_function MDTM_ECOLI GO 0015386 potassium proton antiporter activity; IDA EcoCyc. # GO_process GO:0006855 drug transmembrane transport; IMP:EcoCyc. # GO_process GO:0030641 regulation of cellular pH; IMP:EcoCyc. # GO_process GO:0046677 response to antibiotic; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0042592 homeostatic process # GOslim_process GO:0055085 transmembrane transport # InterPro IPR005829 Sugar_transporter_CS # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # Organism MDTM_ECOLI Escherichia coli (strain K12) # PATRIC 32124280 VBIEscCol129921_4483 # PIR S56562 S56562 # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MDTM_ECOLI Multidrug resistance protein MdtM # RefSeq NP_418757 NC_000913.3 # RefSeq WP_001137036 NZ_LN832404.1 # SIMILARITY Belongs to the major facilitator superfamily. {ECO 0000305}. # SUBCELLULAR LOCATION MDTM_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.2.52 the major facilitator superfamily (mfs) # eggNOG ENOG41083G8 Bacteria # eggNOG ENOG410XT98 LUCA BLAST swissprot:MDTM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MDTM_ECOLI BioCyc ECOL316407:JW4300-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4300-MONOMER BioCyc EcoCyc:YJIO-MONOMER http://biocyc.org/getid?id=EcoCyc:YJIO-MONOMER BioCyc MetaCyc:YJIO-MONOMER http://biocyc.org/getid?id=MetaCyc:YJIO-MONOMER DIP DIP-12641N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12641N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.183.20.5803-5812.2001 http://dx.doi.org/10.1128/JB.183.20.5803-5812.2001 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL AY283773 http://www.ebi.ac.uk/ena/data/view/AY283773 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2464 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2464 EcoGene EG12576 http://www.ecogene.org/geneInfo.php?eg_id=EG12576 EnsemblBacteria AAC77293 http://www.ensemblgenomes.org/id/AAC77293 EnsemblBacteria AAC77293 http://www.ensemblgenomes.org/id/AAC77293 EnsemblBacteria BAE78330 http://www.ensemblgenomes.org/id/BAE78330 EnsemblBacteria BAE78330 http://www.ensemblgenomes.org/id/BAE78330 EnsemblBacteria BAE78330 http://www.ensemblgenomes.org/id/BAE78330 EnsemblBacteria b4337 http://www.ensemblgenomes.org/id/b4337 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015238 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015238 GO_function GO:0015307 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015307 GO_function GO:0015385 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015385 GO_function GO:0015386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015386 GO_process GO:0006855 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006855 GO_process GO:0030641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030641 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 948861 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948861 HOGENOM HOG000118215 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118215&db=HOGENOM6 InParanoid P39386 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39386 InterPro IPR005829 http://www.ebi.ac.uk/interpro/entry/IPR005829 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Gene ecj:JW4300 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4300 KEGG_Gene eco:b4337 http://www.genome.jp/dbget-bin/www_bget?eco:b4337 OMA APCILIP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=APCILIP PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:MDTM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MDTM_ECOLI PSORT-B swissprot:MDTM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MDTM_ECOLI PSORT2 swissprot:MDTM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MDTM_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:MDTM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MDTM_ECOLI PhylomeDB P39386 http://phylomedb.org/?seqid=P39386 ProteinModelPortal P39386 http://www.proteinmodelportal.org/query/uniprot/P39386 PubMed 11566977 http://www.ncbi.nlm.nih.gov/pubmed/11566977 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418757 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418757 RefSeq WP_001137036 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001137036 STRING 511145.b4337 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4337&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.2.52 http://www.tcdb.org/search/result.php?tc=2.A.1.2.52 UniProtKB MDTM_ECOLI http://www.uniprot.org/uniprot/MDTM_ECOLI UniProtKB-AC P39386 http://www.uniprot.org/uniprot/P39386 charge swissprot:MDTM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MDTM_ECOLI eggNOG ENOG41083G8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41083G8 eggNOG ENOG410XT98 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XT98 epestfind swissprot:MDTM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MDTM_ECOLI garnier swissprot:MDTM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MDTM_ECOLI helixturnhelix swissprot:MDTM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MDTM_ECOLI hmoment swissprot:MDTM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MDTM_ECOLI iep swissprot:MDTM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MDTM_ECOLI inforesidue swissprot:MDTM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MDTM_ECOLI octanol swissprot:MDTM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MDTM_ECOLI pepcoil swissprot:MDTM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MDTM_ECOLI pepdigest swissprot:MDTM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MDTM_ECOLI pepinfo swissprot:MDTM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MDTM_ECOLI pepnet swissprot:MDTM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MDTM_ECOLI pepstats swissprot:MDTM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MDTM_ECOLI pepwheel swissprot:MDTM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MDTM_ECOLI pepwindow swissprot:MDTM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MDTM_ECOLI sigcleave swissprot:MDTM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MDTM_ECOLI ## Database ID URL or Descriptions # BioGrid 4262142 12 # CDD cd06261 TM_PBP2 # EcoGene EG10782 pstA # FUNCTION PSTA_ECOLI Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoliWiki. # GO_function GO:0005315 inorganic phosphate transmembrane transporter activity; IEA:InterPro. # GO_function GO:0015415 ATPase-coupled phosphate ion transmembrane transporter activity; IDA:EcoCyc. # GO_process GO:0006817 phosphate ion transport; IDA:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0006950 response to stress # Gene3D 1.10.3720.10 -; 1. # InterPro IPR000515 MetI-like # InterPro IPR005672 Phosphate_PstA # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00222 Phosphate transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism PSTA_ECOLI Escherichia coli (strain K12) # PATRIC 32122949 VBIEscCol129921_3850 # PIR B23311 BVECPT # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PSTA_ECOLI Phosphate transport system permease protein PstA # RefSeq NP_418182 NC_000913.3 # RefSeq WP_001251998 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION PSTA_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00441, ECO 0000269|PubMed 15919996}. # SUPFAM SSF161098 SSF161098 # TCDB 3.A.1.7 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR00974 3a0107s02c # eggNOG COG0581 LUCA # eggNOG ENOG4105E2Z Bacteria BLAST swissprot:PSTA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PSTA_ECOLI BioCyc ECOL316407:JW3704-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3704-MONOMER BioCyc EcoCyc:PSTA-MONOMER http://biocyc.org/getid?id=EcoCyc:PSTA-MONOMER BioCyc MetaCyc:PSTA-MONOMER http://biocyc.org/getid?id=MetaCyc:PSTA-MONOMER COG COG0581 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0581 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1016/0022-2836(85)90377-8 http://dx.doi.org/10.1016/0022-2836(85)90377-8 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.052018199 http://dx.doi.org/10.1073/pnas.052018199 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K01992 http://www.ebi.ac.uk/ena/data/view/K01992 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X02723 http://www.ebi.ac.uk/ena/data/view/X02723 EchoBASE EB0775 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0775 EcoGene EG10782 http://www.ecogene.org/geneInfo.php?eg_id=EG10782 EnsemblBacteria AAC76749 http://www.ensemblgenomes.org/id/AAC76749 EnsemblBacteria AAC76749 http://www.ensemblgenomes.org/id/AAC76749 EnsemblBacteria BAE77562 http://www.ensemblgenomes.org/id/BAE77562 EnsemblBacteria BAE77562 http://www.ensemblgenomes.org/id/BAE77562 EnsemblBacteria BAE77562 http://www.ensemblgenomes.org/id/BAE77562 EnsemblBacteria b3726 http://www.ensemblgenomes.org/id/b3726 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0005315 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005315 GO_function GO:0015415 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015415 GO_process GO:0006817 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006817 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 948239 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948239 HOGENOM HOG000074142 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000074142&db=HOGENOM6 InParanoid P07654 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P07654 InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 InterPro IPR005672 http://www.ebi.ac.uk/interpro/entry/IPR005672 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3704 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3704 KEGG_Gene eco:b3726 http://www.genome.jp/dbget-bin/www_bget?eco:b3726 KEGG_Orthology KO:K02038 http://www.genome.jp/dbget-bin/www_bget?KO:K02038 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA AKMGHFS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AKMGHFS PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:PSTA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PSTA_ECOLI PSORT-B swissprot:PSTA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PSTA_ECOLI PSORT2 swissprot:PSTA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PSTA_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Phobius swissprot:PSTA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PSTA_ECOLI PhylomeDB P07654 http://phylomedb.org/?seqid=P07654 ProteinModelPortal P07654 http://www.proteinmodelportal.org/query/uniprot/P07654 PubMed 11867724 http://www.ncbi.nlm.nih.gov/pubmed/11867724 PubMed 1447208 http://www.ncbi.nlm.nih.gov/pubmed/1447208 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2993631 http://www.ncbi.nlm.nih.gov/pubmed/2993631 PubMed 3881386 http://www.ncbi.nlm.nih.gov/pubmed/3881386 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418182 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418182 RefSeq WP_001251998 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001251998 STRING 511145.b3726 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3726&targetmode=cogs STRING COG0581 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0581&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.7 http://www.tcdb.org/search/result.php?tc=3.A.1.7 TIGRFAMs TIGR00974 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00974 UniProtKB PSTA_ECOLI http://www.uniprot.org/uniprot/PSTA_ECOLI UniProtKB-AC P07654 http://www.uniprot.org/uniprot/P07654 charge swissprot:PSTA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PSTA_ECOLI eggNOG COG0581 http://eggnogapi.embl.de/nog_data/html/tree/COG0581 eggNOG ENOG4105E2Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E2Z epestfind swissprot:PSTA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PSTA_ECOLI garnier swissprot:PSTA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PSTA_ECOLI helixturnhelix swissprot:PSTA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PSTA_ECOLI hmoment swissprot:PSTA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PSTA_ECOLI iep swissprot:PSTA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PSTA_ECOLI inforesidue swissprot:PSTA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PSTA_ECOLI octanol swissprot:PSTA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PSTA_ECOLI pepcoil swissprot:PSTA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PSTA_ECOLI pepdigest swissprot:PSTA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PSTA_ECOLI pepinfo swissprot:PSTA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PSTA_ECOLI pepnet swissprot:PSTA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PSTA_ECOLI pepstats swissprot:PSTA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PSTA_ECOLI pepwheel swissprot:PSTA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PSTA_ECOLI pepwindow swissprot:PSTA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PSTA_ECOLI sigcleave swissprot:PSTA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PSTA_ECOLI ## Database ID URL or Descriptions # AltName PTPC2_ECOLI EIIC-Aga' # AltName PTPC2_ECOLI PTS system N-acetylgalactosamine-specific EIIC component 2 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # DOMAIN PTPC2_ECOLI The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site. # EcoGene EG12765 agaW # FUNCTION PTPC2_ECOLI The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in N-acetylgalactosamine transport. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006810 transport # InterPro IPR004700 PTS_IIC_man # Organism PTPC2_ECOLI Escherichia coli (strain K12) # PIR B65103 B65103 # PROSITE PS51106 PTS_EIIC_TYPE_4 # Pfam PF03609 EII-Sor # Proteomes UP000000625 Chromosome # RecName PTPC2_ECOLI Putative N-acetylgalactosamine permease IIC component 2 # RefSeq WP_000406204 NZ_LN832404.1 # SIMILARITY Contains 1 PTS EIIC type-4 domain. {ECO:0000255|PROSITE-ProRule PRU00429}. # SUBCELLULAR LOCATION PTPC2_ECOLI Cell inner membrane; Multi-pass membrane protein. Note=When overexpressed. BLAST swissprot:PTPC2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTPC2_ECOLI BioCyc EcoCyc:G7633-MONOMER http://biocyc.org/getid?id=EcoCyc:G7633-MONOMER DOI 10.1099/13500872-142-2-231 http://dx.doi.org/10.1099/13500872-142-2-231 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2618 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2618 EcoGene EG12765 http://www.ecogene.org/geneInfo.php?eg_id=EG12765 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 HOGENOM HOG000202513 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000202513&db=HOGENOM6 InterPro IPR004700 http://www.ebi.ac.uk/interpro/entry/IPR004700 PROSITE PS51106 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51106 PSORT swissprot:PTPC2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTPC2_ECOLI PSORT-B swissprot:PTPC2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTPC2_ECOLI PSORT2 swissprot:PTPC2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTPC2_ECOLI Pfam PF03609 http://pfam.xfam.org/family/PF03609 Phobius swissprot:PTPC2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTPC2_ECOLI ProteinModelPortal P42905 http://www.proteinmodelportal.org/query/uniprot/P42905 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 8932697 http://www.ncbi.nlm.nih.gov/pubmed/8932697 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000406204 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000406204 UniProtKB PTPC2_ECOLI http://www.uniprot.org/uniprot/PTPC2_ECOLI UniProtKB-AC P42905 http://www.uniprot.org/uniprot/P42905 charge swissprot:PTPC2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTPC2_ECOLI epestfind swissprot:PTPC2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTPC2_ECOLI garnier swissprot:PTPC2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTPC2_ECOLI helixturnhelix swissprot:PTPC2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTPC2_ECOLI hmoment swissprot:PTPC2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTPC2_ECOLI iep swissprot:PTPC2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTPC2_ECOLI inforesidue swissprot:PTPC2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTPC2_ECOLI octanol swissprot:PTPC2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTPC2_ECOLI pepcoil swissprot:PTPC2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTPC2_ECOLI pepdigest swissprot:PTPC2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTPC2_ECOLI pepinfo swissprot:PTPC2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTPC2_ECOLI pepnet swissprot:PTPC2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTPC2_ECOLI pepstats swissprot:PTPC2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTPC2_ECOLI pepwheel swissprot:PTPC2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTPC2_ECOLI pepwindow swissprot:PTPC2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTPC2_ECOLI sigcleave swissprot:PTPC2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTPC2_ECOLI ## Database ID URL or Descriptions # CAUTION There is no equivalent of this gene in strain K12 / MG1655. {ECO 0000305}. # FUNCTION INSC9_ECOLI Involved in the transposition of the insertion sequence IS2. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 1.10.10.60 -; 1. # InterPro IPR002514 Transposase_8 # InterPro IPR009057 Homeodomain-like # Organism INSC9_ECOLI Escherichia coli (strain K12) # Pfam PF01527 HTH_Tnp_1 # RecName INSC9_ECOLI Transposase InsC for insertion element IS2-9 # RefSeq WP_000567766 NZ_LN832404.1 # SIMILARITY Belongs to the transposase 8 family. {ECO 0000305}. # SUPFAM SSF46689 SSF46689 # eggNOG COG2963 LUCA # eggNOG ENOG4108ZQS Bacteria BLAST swissprot:INSC9_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSC9_ECOLI DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EnsemblBacteria BAA16036 http://www.ensemblgenomes.org/id/BAA16036 EnsemblBacteria BAA16036 http://www.ensemblgenomes.org/id/BAA16036 EnsemblBacteria BAA16036 http://www.ensemblgenomes.org/id/BAA16036 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 InterPro IPR002514 http://www.ebi.ac.uk/interpro/entry/IPR002514 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 KEGG_Gene ecj:JW5902 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5902 PSORT swissprot:INSC9_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSC9_ECOLI PSORT-B swissprot:INSC9_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSC9_ECOLI PSORT2 swissprot:INSC9_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSC9_ECOLI Pfam PF01527 http://pfam.xfam.org/family/PF01527 Phobius swissprot:INSC9_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSC9_ECOLI PhylomeDB P0CF48 http://phylomedb.org/?seqid=P0CF48 ProteinModelPortal P0CF48 http://www.proteinmodelportal.org/query/uniprot/P0CF48 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 RefSeq WP_000567766 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000567766 STRING 511145.b4272 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4272&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 UniProtKB INSC9_ECOLI http://www.uniprot.org/uniprot/INSC9_ECOLI UniProtKB-AC P0CF48 http://www.uniprot.org/uniprot/P0CF48 charge swissprot:INSC9_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSC9_ECOLI eggNOG COG2963 http://eggnogapi.embl.de/nog_data/html/tree/COG2963 eggNOG ENOG4108ZQS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZQS epestfind swissprot:INSC9_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSC9_ECOLI garnier swissprot:INSC9_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSC9_ECOLI helixturnhelix swissprot:INSC9_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSC9_ECOLI hmoment swissprot:INSC9_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSC9_ECOLI iep swissprot:INSC9_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSC9_ECOLI inforesidue swissprot:INSC9_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSC9_ECOLI octanol swissprot:INSC9_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSC9_ECOLI pepcoil swissprot:INSC9_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSC9_ECOLI pepdigest swissprot:INSC9_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSC9_ECOLI pepinfo swissprot:INSC9_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSC9_ECOLI pepnet swissprot:INSC9_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSC9_ECOLI pepstats swissprot:INSC9_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSC9_ECOLI pepwheel swissprot:INSC9_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSC9_ECOLI pepwindow swissprot:INSC9_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSC9_ECOLI sigcleave swissprot:INSC9_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSC9_ECOLI ## Database ID URL or Descriptions # AltName THGA_ECOLI Thiogalactoside acetyltransferase # BRENDA 2.3.1.18 2026 # BioGrid 4263184 12 # CATALYTIC ACTIVITY THGA_ECOLI Acetyl-CoA + a beta-D-galactoside = CoA + a 6- acetyl-beta-D-galactoside. # EcoGene EG10524 lacA # FUNCTION THGA_ECOLI May assist cellular detoxification by acetylating non- metabolizable pyranosides, thereby preventing their reentry into the cell. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0008870 galactoside O-acetyltransferase activity; IDA:EcoCyc. # GO_process GO:0005989 lactose biosynthetic process; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # IntAct P07464 4 # InterPro IPR001451 Hexapep # InterPro IPR011004 Trimer_LpxA-like # InterPro IPR018357 Hexapep_transf_CS # InterPro IPR024688 Mac_dom # KEGG_Brite ko01000 Enzymes # Organism THGA_ECOLI Escherichia coli (strain K12) # PATRIC 32115817 VBIEscCol129921_0350 # PDB 1KQA X-ray; 3.20 A; A/B/C=1-203 # PDB 1KRR X-ray; 2.50 A; A/B/C=1-203 # PDB 1KRU X-ray; 2.80 A; A/B/C=1-203 # PDB 1KRV X-ray; 2.80 A; A/B/C=1-203 # PIR A94061 XXECTG # PROSITE PS00101 HEXAPEP_TRANSFERASES # PTM THGA_ECOLI The N-terminus of this protein is heterogeneous because the initiator methionine is only partially cleaved. # Pfam PF00132 Hexapep # Pfam PF12464 Mac # Pfam PF14602 Hexapep_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName THGA_ECOLI Galactoside O-acetyltransferase # RefSeq NP_414876 NC_000913.3 # RefSeq WP_001335915 NZ_LN832404.1 # SIMILARITY Belongs to the transferase hexapeptide repeat family. {ECO 0000305}. # SMART SM01266 Mac # SUBCELLULAR LOCATION THGA_ECOLI Cytoplasm. # SUBUNIT THGA_ECOLI Homodimer. # SUPFAM SSF51161 SSF51161 # eggNOG COG0110 LUCA # eggNOG ENOG4108UW5 Bacteria BLAST swissprot:THGA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:THGA_ECOLI BioCyc ECOL316407:JW0333-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0333-MONOMER BioCyc EcoCyc:GALACTOACETYLTRAN-MONOMER http://biocyc.org/getid?id=EcoCyc:GALACTOACETYLTRAN-MONOMER BioCyc MetaCyc:GALACTOACETYLTRAN-MONOMER http://biocyc.org/getid?id=MetaCyc:GALACTOACETYLTRAN-MONOMER COG COG0110 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0110 DIP DIP-10078N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10078N DOI 10.1016/S0300-9084(85)80235-2 http://dx.doi.org/10.1016/S0300-9084(85)80235-2 DOI 10.1016/S0969-2126(02)00741-4 http://dx.doi.org/10.1016/S0969-2126(02)00741-4 DOI 10.1038/283541a0 http://dx.doi.org/10.1038/283541a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.82.19.6414 http://dx.doi.org/10.1073/pnas.82.19.6414 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.18 http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.18 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01636 http://www.ebi.ac.uk/ena/data/view/J01636 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EMBL V00295 http://www.ebi.ac.uk/ena/data/view/V00295 EMBL X51872 http://www.ebi.ac.uk/ena/data/view/X51872 ENZYME 2.3.1.18 http://enzyme.expasy.org/EC/2.3.1.18 EchoBASE EB0519 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0519 EcoGene EG10524 http://www.ecogene.org/geneInfo.php?eg_id=EG10524 EnsemblBacteria AAC73445 http://www.ensemblgenomes.org/id/AAC73445 EnsemblBacteria AAC73445 http://www.ensemblgenomes.org/id/AAC73445 EnsemblBacteria BAE76124 http://www.ensemblgenomes.org/id/BAE76124 EnsemblBacteria BAE76124 http://www.ensemblgenomes.org/id/BAE76124 EnsemblBacteria BAE76124 http://www.ensemblgenomes.org/id/BAE76124 EnsemblBacteria b0342 http://www.ensemblgenomes.org/id/b0342 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0008870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008870 GO_process GO:0005989 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005989 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 945674 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945674 HOGENOM HOG000049435 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000049435&db=HOGENOM6 InParanoid P07464 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P07464 IntAct P07464 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P07464* IntEnz 2.3.1.18 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.18 InterPro IPR001451 http://www.ebi.ac.uk/interpro/entry/IPR001451 InterPro IPR011004 http://www.ebi.ac.uk/interpro/entry/IPR011004 InterPro IPR018357 http://www.ebi.ac.uk/interpro/entry/IPR018357 InterPro IPR024688 http://www.ebi.ac.uk/interpro/entry/IPR024688 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0333 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0333 KEGG_Gene eco:b0342 http://www.genome.jp/dbget-bin/www_bget?eco:b0342 KEGG_Orthology KO:K00633 http://www.genome.jp/dbget-bin/www_bget?KO:K00633 OMA HYYYKDY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HYYYKDY PDB 1KQA http://www.ebi.ac.uk/pdbe-srv/view/entry/1KQA PDB 1KRR http://www.ebi.ac.uk/pdbe-srv/view/entry/1KRR PDB 1KRU http://www.ebi.ac.uk/pdbe-srv/view/entry/1KRU PDB 1KRV http://www.ebi.ac.uk/pdbe-srv/view/entry/1KRV PDBsum 1KQA http://www.ebi.ac.uk/pdbsum/1KQA PDBsum 1KRR http://www.ebi.ac.uk/pdbsum/1KRR PDBsum 1KRU http://www.ebi.ac.uk/pdbsum/1KRU PDBsum 1KRV http://www.ebi.ac.uk/pdbsum/1KRV PROSITE PS00101 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00101 PSORT swissprot:THGA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:THGA_ECOLI PSORT-B swissprot:THGA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:THGA_ECOLI PSORT2 swissprot:THGA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:THGA_ECOLI Pfam PF00132 http://pfam.xfam.org/family/PF00132 Pfam PF12464 http://pfam.xfam.org/family/PF12464 Pfam PF14602 http://pfam.xfam.org/family/PF14602 Phobius swissprot:THGA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:THGA_ECOLI PhylomeDB P07464 http://phylomedb.org/?seqid=P07464 ProteinModelPortal P07464 http://www.proteinmodelportal.org/query/uniprot/P07464 PubMed 11937062 http://www.ncbi.nlm.nih.gov/pubmed/11937062 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3901000 http://www.ncbi.nlm.nih.gov/pubmed/3901000 PubMed 3922433 http://www.ncbi.nlm.nih.gov/pubmed/3922433 PubMed 6444453 http://www.ncbi.nlm.nih.gov/pubmed/6444453 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414876 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414876 RefSeq WP_001335915 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001335915 SMART SM01266 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01266 SMR P07464 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P07464 STRING 511145.b0342 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0342&targetmode=cogs STRING COG0110 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0110&targetmode=cogs SUPFAM SSF51161 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51161 UniProtKB THGA_ECOLI http://www.uniprot.org/uniprot/THGA_ECOLI UniProtKB-AC P07464 http://www.uniprot.org/uniprot/P07464 charge swissprot:THGA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:THGA_ECOLI eggNOG COG0110 http://eggnogapi.embl.de/nog_data/html/tree/COG0110 eggNOG ENOG4108UW5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UW5 epestfind swissprot:THGA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:THGA_ECOLI garnier swissprot:THGA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:THGA_ECOLI helixturnhelix swissprot:THGA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:THGA_ECOLI hmoment swissprot:THGA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:THGA_ECOLI iep swissprot:THGA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:THGA_ECOLI inforesidue swissprot:THGA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:THGA_ECOLI octanol swissprot:THGA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:THGA_ECOLI pepcoil swissprot:THGA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:THGA_ECOLI pepdigest swissprot:THGA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:THGA_ECOLI pepinfo swissprot:THGA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:THGA_ECOLI pepnet swissprot:THGA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:THGA_ECOLI pepstats swissprot:THGA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:THGA_ECOLI pepwheel swissprot:THGA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:THGA_ECOLI pepwindow swissprot:THGA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:THGA_ECOLI sigcleave swissprot:THGA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:THGA_ECOLI ## Database ID URL or Descriptions # BioGrid 4263201 6 # ESTHER ecoli-yiel A85-Feruloyl-Esterase # EcoGene EG11729 yieL # GO_component GO:0005576 extracellular region; IBA:GO_Central. # GO_function GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro. # GO_function GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups; IBA:GO_Central. # GO_process GO:0005975 carbohydrate metabolic process; IEA:InterPro. # GO_process GO:0071769 mycolate cell wall layer assembly; IBA:GO_Central. # GOslim_component GO:0005576 extracellular region # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0022607 cellular component assembly # Gene3D 2.60.40.10 -; 1. # Gene3D 3.40.50.1820 -; 1. # InterPro IPR000801 Esterase_put # InterPro IPR004193 Glyco_hydro_13_N # InterPro IPR013783 Ig-like_fold # InterPro IPR014756 Ig_E-set # InterPro IPR029058 AB_hydrolase # Organism YIEL_ECOLI Escherichia coli (strain K12) # PATRIC 32122933 VBIEscCol129921_3842 # PIR H65174 H65174 # Pfam PF00756 Esterase # Pfam PF02922 CBM_48 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIEL_ECOLI Uncharacterized protein YieL # RefSeq NP_418175 NC_000913.3 # RefSeq WP_001336377 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA62070.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAE77569.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SUPFAM SSF53474 SSF53474 # SUPFAM SSF81296 SSF81296 # eggNOG COG2382 LUCA # eggNOG ENOG4105DYC Bacteria BLAST swissprot:YIEL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIEL_ECOLI BioCyc ECOL316407:JW5612-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5612-MONOMER BioCyc EcoCyc:EG11729-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11729-MONOMER COG COG2382 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2382 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1680 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1680 EcoGene EG11729 http://www.ecogene.org/geneInfo.php?eg_id=EG11729 EnsemblBacteria AAC76742 http://www.ensemblgenomes.org/id/AAC76742 EnsemblBacteria AAC76742 http://www.ensemblgenomes.org/id/AAC76742 EnsemblBacteria BAE77569 http://www.ensemblgenomes.org/id/BAE77569 EnsemblBacteria BAE77569 http://www.ensemblgenomes.org/id/BAE77569 EnsemblBacteria BAE77569 http://www.ensemblgenomes.org/id/BAE77569 EnsemblBacteria b3719 http://www.ensemblgenomes.org/id/b3719 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005576 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576 GO_function GO:0004553 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004553 GO_function GO:0016747 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016747 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GO_process GO:0071769 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071769 GOslim_component GO:0005576 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 Gene3D 2.60.40.10 http://www.cathdb.info/version/latest/superfamily/2.60.40.10 Gene3D 3.40.50.1820 http://www.cathdb.info/version/latest/superfamily/3.40.50.1820 GeneID 948272 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948272 HOGENOM HOG000126392 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126392&db=HOGENOM6 InParanoid P31471 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31471 InterPro IPR000801 http://www.ebi.ac.uk/interpro/entry/IPR000801 InterPro IPR004193 http://www.ebi.ac.uk/interpro/entry/IPR004193 InterPro IPR013783 http://www.ebi.ac.uk/interpro/entry/IPR013783 InterPro IPR014756 http://www.ebi.ac.uk/interpro/entry/IPR014756 InterPro IPR029058 http://www.ebi.ac.uk/interpro/entry/IPR029058 KEGG_Gene ecj:JW5612 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5612 KEGG_Gene eco:b3719 http://www.genome.jp/dbget-bin/www_bget?eco:b3719 KEGG_Orthology KO:K07214 http://www.genome.jp/dbget-bin/www_bget?KO:K07214 OMA VACERRI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VACERRI PSORT swissprot:YIEL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIEL_ECOLI PSORT-B swissprot:YIEL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIEL_ECOLI PSORT2 swissprot:YIEL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIEL_ECOLI Pfam PF00756 http://pfam.xfam.org/family/PF00756 Pfam PF02922 http://pfam.xfam.org/family/PF02922 Phobius swissprot:YIEL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIEL_ECOLI PhylomeDB P31471 http://phylomedb.org/?seqid=P31471 ProteinModelPortal P31471 http://www.proteinmodelportal.org/query/uniprot/P31471 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418175 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418175 RefSeq WP_001336377 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001336377 STRING 511145.b3719 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3719&targetmode=cogs STRING COG2382 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2382&targetmode=cogs SUPFAM SSF53474 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53474 SUPFAM SSF81296 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81296 SWISS-2DPAGE P31471 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P31471 UniProtKB YIEL_ECOLI http://www.uniprot.org/uniprot/YIEL_ECOLI UniProtKB-AC P31471 http://www.uniprot.org/uniprot/P31471 charge swissprot:YIEL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIEL_ECOLI eggNOG COG2382 http://eggnogapi.embl.de/nog_data/html/tree/COG2382 eggNOG ENOG4105DYC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DYC epestfind swissprot:YIEL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIEL_ECOLI garnier swissprot:YIEL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIEL_ECOLI helixturnhelix swissprot:YIEL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIEL_ECOLI hmoment swissprot:YIEL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIEL_ECOLI iep swissprot:YIEL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIEL_ECOLI inforesidue swissprot:YIEL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIEL_ECOLI octanol swissprot:YIEL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIEL_ECOLI pepcoil swissprot:YIEL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIEL_ECOLI pepdigest swissprot:YIEL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIEL_ECOLI pepinfo swissprot:YIEL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIEL_ECOLI pepnet swissprot:YIEL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIEL_ECOLI pepstats swissprot:YIEL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIEL_ECOLI pepwheel swissprot:YIEL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIEL_ECOLI pepwindow swissprot:YIEL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIEL_ECOLI sigcleave swissprot:YIEL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIEL_ECOLI ## Database ID URL or Descriptions # BioGrid 4259331 21 # EcoGene EG12379 yecE # Gene3D 3.20.20.410 -; 1. # IntAct P37348 3 # InterPro IPR002763 DUF72 # Organism YECE_ECOLI Escherichia coli (strain K12) # PATRIC 32119059 VBIEscCol129921_1947 # PIR D64949 D64949 # Pfam PF01904 DUF72 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YECE_ECOLI UPF0759 protein YecE # RefSeq NP_416382 NC_000913.3 # RefSeq WP_000639274 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0759 family. {ECO 0000305}. # SUPFAM SSF117396 SSF117396 # eggNOG COG1801 LUCA # eggNOG ENOG41081XQ Bacteria BLAST swissprot:YECE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YECE_ECOLI BioCyc ECOL316407:JW1857-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1857-MONOMER BioCyc EcoCyc:EG12379-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12379-MONOMER DIP DIP-11824N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11824N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/nar/18.23.7109 http://dx.doi.org/10.1093/nar/18.23.7109 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X53863 http://www.ebi.ac.uk/ena/data/view/X53863 EchoBASE EB2281 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2281 EcoGene EG12379 http://www.ecogene.org/geneInfo.php?eg_id=EG12379 EnsemblBacteria AAC74938 http://www.ensemblgenomes.org/id/AAC74938 EnsemblBacteria AAC74938 http://www.ensemblgenomes.org/id/AAC74938 EnsemblBacteria BAA15679 http://www.ensemblgenomes.org/id/BAA15679 EnsemblBacteria BAA15679 http://www.ensemblgenomes.org/id/BAA15679 EnsemblBacteria BAA15679 http://www.ensemblgenomes.org/id/BAA15679 EnsemblBacteria b1868 http://www.ensemblgenomes.org/id/b1868 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.20.20.410 http://www.cathdb.info/version/latest/superfamily/3.20.20.410 GeneID 946382 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946382 HOGENOM HOG000275148 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275148&db=HOGENOM6 InParanoid P37348 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37348 IntAct P37348 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37348* InterPro IPR002763 http://www.ebi.ac.uk/interpro/entry/IPR002763 KEGG_Gene ecj:JW1857 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1857 KEGG_Gene eco:b1868 http://www.genome.jp/dbget-bin/www_bget?eco:b1868 OMA GCPSWSE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GCPSWSE PSORT swissprot:YECE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YECE_ECOLI PSORT-B swissprot:YECE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YECE_ECOLI PSORT2 swissprot:YECE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YECE_ECOLI Pfam PF01904 http://pfam.xfam.org/family/PF01904 Phobius swissprot:YECE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YECE_ECOLI PhylomeDB P37348 http://phylomedb.org/?seqid=P37348 ProteinModelPortal P37348 http://www.proteinmodelportal.org/query/uniprot/P37348 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2129559 http://www.ncbi.nlm.nih.gov/pubmed/2129559 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416382 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416382 RefSeq WP_000639274 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000639274 STRING 511145.b1868 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1868&targetmode=cogs SUPFAM SSF117396 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF117396 UniProtKB YECE_ECOLI http://www.uniprot.org/uniprot/YECE_ECOLI UniProtKB-AC P37348 http://www.uniprot.org/uniprot/P37348 charge swissprot:YECE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YECE_ECOLI eggNOG COG1801 http://eggnogapi.embl.de/nog_data/html/tree/COG1801 eggNOG ENOG41081XQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG41081XQ epestfind swissprot:YECE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YECE_ECOLI garnier swissprot:YECE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YECE_ECOLI helixturnhelix swissprot:YECE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YECE_ECOLI hmoment swissprot:YECE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YECE_ECOLI iep swissprot:YECE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YECE_ECOLI inforesidue swissprot:YECE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YECE_ECOLI octanol swissprot:YECE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YECE_ECOLI pepcoil swissprot:YECE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YECE_ECOLI pepdigest swissprot:YECE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YECE_ECOLI pepinfo swissprot:YECE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YECE_ECOLI pepnet swissprot:YECE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YECE_ECOLI pepstats swissprot:YECE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YECE_ECOLI pepwheel swissprot:YECE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YECE_ECOLI pepwindow swissprot:YECE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YECE_ECOLI sigcleave swissprot:YECE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YECE_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES pH dependence Optimum pH is about 4.; # BioGrid 4259551 10 # CATALYTIC ACTIVITY AGP_ECOLI Alpha-D-glucose 1-phosphate + H(2)O = D- glucose + phosphate. # CDD cd07061 HP_HAP_like # ENZYME REGULATION AGP_ECOLI Independent from inorganic phosphate availability, and apparently submitted to catabolite repression, it is positively controlled by cAMP and the cAMP receptor protein. # EcoGene EG10033 agp # FUNCTION AGP_ECOLI Absolutely required for the growth of E.coli in a high- phosphate medium containing G-1-P as the sole carbon source. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0003993 acid phosphatase activity; IEA:InterPro. # GO_function GO:0008877 glucose-1-phosphatase activity; IDA:EcoCyc. # GO_function GO:0016158 3-phytase activity; IDA:EcoCyc. # GO_process GO:0006007 glucose catabolic process; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016791 phosphatase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.1240 -; 3. # IntAct P19926 3 # InterPro IPR000560 His_Pase_clade-2 # InterPro IPR029033 His_PPase_superfam # InterPro IPR033379 Acid_Pase_AS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00010 Glycolysis / Gluconeogenesis # Organism AGP_ECOLI Escherichia coli (strain K12) # PATRIC 32117229 VBIEscCol129921_1038 # PDB 1NT4 X-ray; 2.40 A; A/B=23-413 # PIR JV0087 JV0087 # PROSITE PS00616 HIS_ACID_PHOSPHAT_1 # PROSITE PS00778 HIS_ACID_PHOSPHAT_2 # Pfam PF00328 His_Phos_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AGP_ECOLI Glucose-1-phosphatase # RefSeq NP_415522 NC_000913.3 # RefSeq WP_001044279 NZ_LN832404.1 # SIMILARITY Belongs to the histidine acid phosphatase family. {ECO 0000305}. # SUBCELLULAR LOCATION AGP_ECOLI Periplasm. # SUBUNIT Homodimer. {ECO:0000269|PubMed 12782623}. # SUPFAM SSF53254 SSF53254 # eggNOG ENOG4105D6F Bacteria # eggNOG ENOG410XRK8 LUCA BLAST swissprot:AGP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AGP_ECOLI BioCyc ECOL316407:JW0987-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0987-MONOMER BioCyc EcoCyc:GLUCOSE-1-PHOSPHAT-MONOMER http://biocyc.org/getid?id=EcoCyc:GLUCOSE-1-PHOSPHAT-MONOMER BioCyc MetaCyc:GLUCOSE-1-PHOSPHAT-MONOMER http://biocyc.org/getid?id=MetaCyc:GLUCOSE-1-PHOSPHAT-MONOMER DIP DIP-2905N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-2905N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M213154200 http://dx.doi.org/10.1074/jbc.M213154200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.3.10 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.10 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M33807 http://www.ebi.ac.uk/ena/data/view/M33807 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.3.10 http://enzyme.expasy.org/EC/3.1.3.10 EchoBASE EB0032 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0032 EcoGene EG10033 http://www.ecogene.org/geneInfo.php?eg_id=EG10033 EnsemblBacteria AAC74087 http://www.ensemblgenomes.org/id/AAC74087 EnsemblBacteria AAC74087 http://www.ensemblgenomes.org/id/AAC74087 EnsemblBacteria BAA35769 http://www.ensemblgenomes.org/id/BAA35769 EnsemblBacteria BAA35769 http://www.ensemblgenomes.org/id/BAA35769 EnsemblBacteria BAA35769 http://www.ensemblgenomes.org/id/BAA35769 EnsemblBacteria b1002 http://www.ensemblgenomes.org/id/b1002 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0003993 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003993 GO_function GO:0008877 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008877 GO_function GO:0016158 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016158 GO_process GO:0006007 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006007 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.1240 http://www.cathdb.info/version/latest/superfamily/3.40.50.1240 GeneID 945773 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945773 HOGENOM HOG000118851 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118851&db=HOGENOM6 InParanoid P19926 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P19926 IntAct P19926 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P19926* IntEnz 3.1.3.10 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.10 InterPro IPR000560 http://www.ebi.ac.uk/interpro/entry/IPR000560 InterPro IPR029033 http://www.ebi.ac.uk/interpro/entry/IPR029033 InterPro IPR033379 http://www.ebi.ac.uk/interpro/entry/IPR033379 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0987 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0987 KEGG_Gene eco:b1002 http://www.genome.jp/dbget-bin/www_bget?eco:b1002 KEGG_Orthology KO:K01085 http://www.genome.jp/dbget-bin/www_bget?KO:K01085 KEGG_Pathway ko00010 http://www.genome.jp/kegg-bin/show_pathway?ko00010 KEGG_Reaction rn:R00947 http://www.genome.jp/dbget-bin/www_bget?rn:R00947 OMA AWGEIKT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AWGEIKT PDB 1NT4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1NT4 PDBsum 1NT4 http://www.ebi.ac.uk/pdbsum/1NT4 PROSITE PS00616 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00616 PROSITE PS00778 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00778 PSORT swissprot:AGP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AGP_ECOLI PSORT-B swissprot:AGP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AGP_ECOLI PSORT2 swissprot:AGP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AGP_ECOLI Pfam PF00328 http://pfam.xfam.org/family/PF00328 Phobius swissprot:AGP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AGP_ECOLI ProteinModelPortal P19926 http://www.proteinmodelportal.org/query/uniprot/P19926 PubMed 12782623 http://www.ncbi.nlm.nih.gov/pubmed/12782623 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2153660 http://www.ncbi.nlm.nih.gov/pubmed/2153660 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_415522 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415522 RefSeq WP_001044279 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001044279 SMR P19926 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P19926 STRING 511145.b1002 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1002&targetmode=cogs SUPFAM SSF53254 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53254 UniProtKB AGP_ECOLI http://www.uniprot.org/uniprot/AGP_ECOLI UniProtKB-AC P19926 http://www.uniprot.org/uniprot/P19926 charge swissprot:AGP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AGP_ECOLI eggNOG ENOG4105D6F http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D6F eggNOG ENOG410XRK8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRK8 epestfind swissprot:AGP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AGP_ECOLI garnier swissprot:AGP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AGP_ECOLI helixturnhelix swissprot:AGP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AGP_ECOLI hmoment swissprot:AGP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AGP_ECOLI iep swissprot:AGP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AGP_ECOLI inforesidue swissprot:AGP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AGP_ECOLI octanol swissprot:AGP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AGP_ECOLI pepcoil swissprot:AGP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AGP_ECOLI pepdigest swissprot:AGP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AGP_ECOLI pepinfo swissprot:AGP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AGP_ECOLI pepnet swissprot:AGP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AGP_ECOLI pepstats swissprot:AGP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AGP_ECOLI pepwheel swissprot:AGP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AGP_ECOLI pepwindow swissprot:AGP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AGP_ECOLI sigcleave swissprot:AGP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AGP_ECOLI ## Database ID URL or Descriptions # AltName RPE_ECOLI Pentose-5-phosphate 3-epimerase # AltName RPE_ECOLI R5P3E # BioGrid 4259295 150 # CATALYTIC ACTIVITY D-ribulose 5-phosphate = D-xylulose 5- phosphate. {ECO:0000269|PubMed 21402925}. # CDD cd00429 RPE # COFACTOR RPE_ECOLI Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000269|PubMed 21402925}; Name=Fe(2+); Xref=ChEBI CHEBI 29033; Evidence={ECO 0000269|PubMed 21402925}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 21402925}; Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 21402925}; Note=Binds 1 divalent metal cation per subunit. Active with Co(2+), Fe(2+), Mn(2+) and Zn(2+). {ECO 0000269|PubMed 21402925}; # EcoGene EG11960 rpe # FUNCTION RPE_ECOLI Catalyzes the reversible epimerization of D-ribulose 5- phosphate to D-xylulose 5-phosphate. {ECO 0000269|PubMed 21402925}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004750 ribulose-phosphate 3-epimerase activity; IDA:EcoCyc. # GO_function GO:0008198 ferrous iron binding; IDA:EcoCyc. # GO_process GO:0006098 pentose-phosphate shunt; IEA:InterPro. # GO_process GO:0019323 pentose catabolic process; IMP:EcoCyc. # GO_process GO:0044262 cellular carbohydrate metabolic process; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.20.20.70 -; 1. # INTERACTION RPE_ECOLI P0A988 dnaN; NbExp=3; IntAct=EBI-546020, EBI-542385; P45543 frlD; NbExp=4; IntAct=EBI-546020, EBI-562037; # IntAct P0AG07 24 # InterPro IPR000056 Ribul_P_3_epim-like # InterPro IPR011060 RibuloseP-bd_barrel # InterPro IPR013785 Aldolase_TIM # InterPro IPR026019 Ribul_P_3_epim # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00030 Pentose phosphate pathway # KEGG_Pathway ko00040 Pentose and glucuronate interconversions # KEGG_Pathway ko00710 Carbon fixation in photosynthetic organisms # Organism RPE_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11749 PTHR11749 # PATRIC 32122204 VBIEscCol129921_3479 # PIR E65133 E65133 # PIRSF PIRSF001461 RPE # PROSITE PS01085 RIBUL_P_3_EPIMER_1 # PROSITE PS01086 RIBUL_P_3_EPIMER_2 # Pfam PF00834 Ribul_P_3_epim # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RPE_ECOLI Ribulose-phosphate 3-epimerase # RefSeq NP_417845 NC_000913.3 # RefSeq WP_000816280 NZ_LN832404.1 # SIMILARITY Belongs to the ribulose-phosphate 3-epimerase family. {ECO 0000305}. # SUPFAM SSF51366 SSF51366 # TIGRFAMs TIGR01163 rpe # eggNOG COG0036 LUCA # eggNOG ENOG4105DJV Bacteria BLAST swissprot:RPE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RPE_ECOLI BioCyc ECOL316407:JW3349-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3349-MONOMER BioCyc EcoCyc:RIBULP3EPIM-MONOMER http://biocyc.org/getid?id=EcoCyc:RIBULP3EPIM-MONOMER BioCyc MetaCyc:RIBULP3EPIM-MONOMER http://biocyc.org/getid?id=MetaCyc:RIBULP3EPIM-MONOMER COG COG0036 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0036 DIP DIP-47869N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47869N DOI 10.1007/BF00290345 http://dx.doi.org/10.1007/BF00290345 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.1100410108 http://dx.doi.org/10.1073/pnas.1100410108 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.1.3.1 http://www.genome.jp/dbget-bin/www_bget?EC:5.1.3.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL Z19601 http://www.ebi.ac.uk/ena/data/view/Z19601 ENZYME 5.1.3.1 http://enzyme.expasy.org/EC/5.1.3.1 EchoBASE EB1903 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1903 EcoGene EG11960 http://www.ecogene.org/geneInfo.php?eg_id=EG11960 EnsemblBacteria AAC76411 http://www.ensemblgenomes.org/id/AAC76411 EnsemblBacteria AAC76411 http://www.ensemblgenomes.org/id/AAC76411 EnsemblBacteria BAE77905 http://www.ensemblgenomes.org/id/BAE77905 EnsemblBacteria BAE77905 http://www.ensemblgenomes.org/id/BAE77905 EnsemblBacteria BAE77905 http://www.ensemblgenomes.org/id/BAE77905 EnsemblBacteria b3386 http://www.ensemblgenomes.org/id/b3386 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004750 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004750 GO_function GO:0008198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008198 GO_process GO:0006098 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006098 GO_process GO:0019323 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019323 GO_process GO:0044262 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044262 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 947896 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947896 HOGENOM HOG000259347 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000259347&db=HOGENOM6 InParanoid P0AG07 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AG07 IntAct P0AG07 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AG07* IntEnz 5.1.3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.1.3.1 InterPro IPR000056 http://www.ebi.ac.uk/interpro/entry/IPR000056 InterPro IPR011060 http://www.ebi.ac.uk/interpro/entry/IPR011060 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR026019 http://www.ebi.ac.uk/interpro/entry/IPR026019 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3349 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3349 KEGG_Gene eco:b3386 http://www.genome.jp/dbget-bin/www_bget?eco:b3386 KEGG_Orthology KO:K01783 http://www.genome.jp/dbget-bin/www_bget?KO:K01783 KEGG_Pathway ko00030 http://www.genome.jp/kegg-bin/show_pathway?ko00030 KEGG_Pathway ko00040 http://www.genome.jp/kegg-bin/show_pathway?ko00040 KEGG_Pathway ko00710 http://www.genome.jp/kegg-bin/show_pathway?ko00710 KEGG_Reaction rn:R01529 http://www.genome.jp/dbget-bin/www_bget?rn:R01529 MINT MINT-1228320 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1228320 OMA HYEACTH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HYEACTH PANTHER PTHR11749 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11749 PROSITE PS01085 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01085 PROSITE PS01086 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01086 PSORT swissprot:RPE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RPE_ECOLI PSORT-B swissprot:RPE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RPE_ECOLI PSORT2 swissprot:RPE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RPE_ECOLI Pfam PF00834 http://pfam.xfam.org/family/PF00834 Phobius swissprot:RPE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RPE_ECOLI PhylomeDB P0AG07 http://phylomedb.org/?seqid=P0AG07 ProteinModelPortal P0AG07 http://www.proteinmodelportal.org/query/uniprot/P0AG07 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21402925 http://www.ncbi.nlm.nih.gov/pubmed/21402925 PubMed 7603433 http://www.ncbi.nlm.nih.gov/pubmed/7603433 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417845 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417845 RefSeq WP_000816280 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000816280 SMR P0AG07 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AG07 STRING 511145.b3386 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3386&targetmode=cogs STRING COG0036 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0036&targetmode=cogs SUPFAM SSF51366 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51366 TIGRFAMs TIGR01163 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01163 UniProtKB RPE_ECOLI http://www.uniprot.org/uniprot/RPE_ECOLI UniProtKB-AC P0AG07 http://www.uniprot.org/uniprot/P0AG07 charge swissprot:RPE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RPE_ECOLI eggNOG COG0036 http://eggnogapi.embl.de/nog_data/html/tree/COG0036 eggNOG ENOG4105DJV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DJV epestfind swissprot:RPE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RPE_ECOLI garnier swissprot:RPE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RPE_ECOLI helixturnhelix swissprot:RPE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RPE_ECOLI hmoment swissprot:RPE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RPE_ECOLI iep swissprot:RPE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RPE_ECOLI inforesidue swissprot:RPE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RPE_ECOLI octanol swissprot:RPE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RPE_ECOLI pepcoil swissprot:RPE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RPE_ECOLI pepdigest swissprot:RPE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RPE_ECOLI pepinfo swissprot:RPE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RPE_ECOLI pepnet swissprot:RPE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RPE_ECOLI pepstats swissprot:RPE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RPE_ECOLI pepwheel swissprot:RPE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RPE_ECOLI pepwindow swissprot:RPE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RPE_ECOLI sigcleave swissprot:RPE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RPE_ECOLI ## Database ID URL or Descriptions # BRENDA 3.6.3.20 2026 # BioGrid 4261664 218 # CDD cd06261 TM_PBP2 # EcoGene EG11049 ugpE # FUNCTION UGPE_ECOLI Part of the binding-protein-dependent transport system for sn-glycerol-3-phosphate; probably responsible for the translocation of the substrate across the membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IEA:InterPro. # GO_component GO:0055052 ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing; IDA:EcoCyc. # GO_function GO:0001406 glycerophosphodiester transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0015169 glycerol-3-phosphate transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0001407 glycerophosphodiester transport; IDA:EcoCyc. # GO_process GO:0015794 glycerol-3-phosphate transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # Gene3D 1.10.3720.10 -; 1. # InterPro IPR000515 MetI-like # InterPro IPR030165 UgpE # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00198 Putative sn-glycerol-phosphate transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism UGPE_ECOLI Escherichia coli (strain K12) # PANTHER PTHR32243:SF31 PTHR32243:SF31 # PATRIC 32122342 VBIEscCol129921_3548 # PIR S03782 MMECUE # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UGPE_ECOLI sn-glycerol-3-phosphate transport system permease protein UgpE # RefSeq NP_417908 NC_000913.3 # RefSeq WP_000572177 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. UgpAE subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION UGPE_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00441, ECO 0000269|PubMed 15919996}. # SUBUNIT The complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute- binding protein (UgpB). {ECO 0000305}. # SUPFAM SSF161098 SSF161098 # TCDB 3.A.1.1 the atp-binding cassette (abc) superfamily # eggNOG COG0395 LUCA # eggNOG ENOG4105EX2 Bacteria BLAST swissprot:UGPE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UGPE_ECOLI BioCyc ECOL316407:JW3416-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3416-MONOMER BioCyc EcoCyc:UGPE-MONOMER http://biocyc.org/getid?id=EcoCyc:UGPE-MONOMER BioCyc MetaCyc:UGPE-MONOMER http://biocyc.org/getid?id=MetaCyc:UGPE-MONOMER COG COG0395 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0395 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1111/j.1365-2958.1988.tb00088.x http://dx.doi.org/10.1111/j.1365-2958.1988.tb00088.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X13141 http://www.ebi.ac.uk/ena/data/view/X13141 EchoBASE EB1042 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1042 EcoGene EG11049 http://www.ecogene.org/geneInfo.php?eg_id=EG11049 EnsemblBacteria AAC76476 http://www.ensemblgenomes.org/id/AAC76476 EnsemblBacteria AAC76476 http://www.ensemblgenomes.org/id/AAC76476 EnsemblBacteria BAE77842 http://www.ensemblgenomes.org/id/BAE77842 EnsemblBacteria BAE77842 http://www.ensemblgenomes.org/id/BAE77842 EnsemblBacteria BAE77842 http://www.ensemblgenomes.org/id/BAE77842 EnsemblBacteria b3451 http://www.ensemblgenomes.org/id/b3451 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0055052 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055052 GO_function GO:0001406 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001406 GO_function GO:0015169 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015169 GO_process GO:0001407 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001407 GO_process GO:0015794 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015794 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 947959 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947959 HOGENOM HOG000220524 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220524&db=HOGENOM6 InParanoid P10906 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P10906 IntAct P10906 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P10906* InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 InterPro IPR030165 http://www.ebi.ac.uk/interpro/entry/IPR030165 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3416 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3416 KEGG_Gene eco:b3451 http://www.genome.jp/dbget-bin/www_bget?eco:b3451 KEGG_Orthology KO:K05815 http://www.genome.jp/dbget-bin/www_bget?KO:K05815 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA ATDWNLL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ATDWNLL PANTHER PTHR32243:SF31 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32243:SF31 PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:UGPE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UGPE_ECOLI PSORT-B swissprot:UGPE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UGPE_ECOLI PSORT2 swissprot:UGPE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UGPE_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Phobius swissprot:UGPE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UGPE_ECOLI PhylomeDB P10906 http://phylomedb.org/?seqid=P10906 ProteinModelPortal P10906 http://www.proteinmodelportal.org/query/uniprot/P10906 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3062310 http://www.ncbi.nlm.nih.gov/pubmed/3062310 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417908 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417908 RefSeq WP_000572177 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000572177 STRING 511145.b3451 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3451&targetmode=cogs STRING COG0395 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0395&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.1 http://www.tcdb.org/search/result.php?tc=3.A.1.1 UniProtKB UGPE_ECOLI http://www.uniprot.org/uniprot/UGPE_ECOLI UniProtKB-AC P10906 http://www.uniprot.org/uniprot/P10906 charge swissprot:UGPE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UGPE_ECOLI eggNOG COG0395 http://eggnogapi.embl.de/nog_data/html/tree/COG0395 eggNOG ENOG4105EX2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EX2 epestfind swissprot:UGPE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UGPE_ECOLI garnier swissprot:UGPE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UGPE_ECOLI helixturnhelix swissprot:UGPE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UGPE_ECOLI hmoment swissprot:UGPE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UGPE_ECOLI iep swissprot:UGPE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UGPE_ECOLI inforesidue swissprot:UGPE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UGPE_ECOLI octanol swissprot:UGPE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UGPE_ECOLI pepcoil swissprot:UGPE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UGPE_ECOLI pepdigest swissprot:UGPE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UGPE_ECOLI pepinfo swissprot:UGPE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UGPE_ECOLI pepnet swissprot:UGPE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UGPE_ECOLI pepstats swissprot:UGPE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UGPE_ECOLI pepwheel swissprot:UGPE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UGPE_ECOLI pepwindow swissprot:UGPE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UGPE_ECOLI sigcleave swissprot:UGPE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UGPE_ECOLI ## Database ID URL or Descriptions # BRENDA 3.1.4 2026 # BioGrid 4260646 2 # COFACTOR YAEI_ECOLI Name=a divalent metal cation; Xref=ChEBI CHEBI 60240; Evidence={ECO 0000250}; Note=Binds 2 divalent metal cations. {ECO 0000250}; # EcoGene EG12337 yaeI # FUNCTION YAEI_ECOLI Shows phosphodiesterase activity, hydrolyzing phosphodiester bond in the artificial chromogenic substrate bis-p- nitrophenyl phosphate (bis-pNPP). {ECO 0000269|PubMed 15808744}. # GO_function GO:0016787 hydrolase activity; IEA:UniProtKB-KW. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # Gene3D 3.60.21.10 -; 1. # InterPro IPR004843 Calcineurin-like_PHP_ApaH # InterPro IPR029052 Metallo-depent_PP-like # Organism YAEI_ECOLI Escherichia coli (strain K12) # PATRIC 32115437 VBIEscCol129921_0170 # PIR D64740 D64740 # Pfam PF00149 Metallophos # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAEI_ECOLI Phosphodiesterase YaeI # RefSeq NP_414706 NC_000913.3 # RefSeq WP_000625631 NZ_LN832404.1 # SIMILARITY Belongs to the metallophosphoesterase superfamily. {ECO 0000305}. # SUPFAM SSF56300 SSF56300 # eggNOG COG1408 LUCA # eggNOG ENOG4105DIN Bacteria BLAST swissprot:YAEI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAEI_ECOLI BioCyc ECOL316407:JW5014-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5014-MONOMER BioCyc EcoCyc:EG12337-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12337-MONOMER COG COG1408 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1408 DOI 10.1016/j.fmrre.2004.12.006 http://dx.doi.org/10.1016/j.fmrre.2004.12.006 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.4.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.4.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 ENZYME 3.1.4.- http://enzyme.expasy.org/EC/3.1.4.- EchoBASE EB2241 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2241 EcoGene EG12337 http://www.ecogene.org/geneInfo.php?eg_id=EG12337 EnsemblBacteria AAC73275 http://www.ensemblgenomes.org/id/AAC73275 EnsemblBacteria AAC73275 http://www.ensemblgenomes.org/id/AAC73275 EnsemblBacteria BAB96741 http://www.ensemblgenomes.org/id/BAB96741 EnsemblBacteria BAB96741 http://www.ensemblgenomes.org/id/BAB96741 EnsemblBacteria BAB96741 http://www.ensemblgenomes.org/id/BAB96741 EnsemblBacteria b0164 http://www.ensemblgenomes.org/id/b0164 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016787 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016787 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.60.21.10 http://www.cathdb.info/version/latest/superfamily/3.60.21.10 GeneID 945002 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945002 HOGENOM HOG000260481 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260481&db=HOGENOM6 InParanoid P37049 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37049 IntEnz 3.1.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.4 InterPro IPR004843 http://www.ebi.ac.uk/interpro/entry/IPR004843 InterPro IPR029052 http://www.ebi.ac.uk/interpro/entry/IPR029052 KEGG_Gene ecj:JW5014 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5014 KEGG_Gene eco:b0164 http://www.genome.jp/dbget-bin/www_bget?eco:b0164 KEGG_Orthology KO:K07098 http://www.genome.jp/dbget-bin/www_bget?KO:K07098 OMA PLITPPY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PLITPPY PSORT swissprot:YAEI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAEI_ECOLI PSORT-B swissprot:YAEI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAEI_ECOLI PSORT2 swissprot:YAEI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAEI_ECOLI Pfam PF00149 http://pfam.xfam.org/family/PF00149 Phobius swissprot:YAEI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAEI_ECOLI PhylomeDB P37049 http://phylomedb.org/?seqid=P37049 ProteinModelPortal P37049 http://www.proteinmodelportal.org/query/uniprot/P37049 PubMed 15808744 http://www.ncbi.nlm.nih.gov/pubmed/15808744 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414706 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414706 RefSeq WP_000625631 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000625631 SMR P37049 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37049 STRING 511145.b0164 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0164&targetmode=cogs STRING COG1408 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1408&targetmode=cogs SUPFAM SSF56300 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56300 UniProtKB YAEI_ECOLI http://www.uniprot.org/uniprot/YAEI_ECOLI UniProtKB-AC P37049 http://www.uniprot.org/uniprot/P37049 charge swissprot:YAEI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAEI_ECOLI eggNOG COG1408 http://eggnogapi.embl.de/nog_data/html/tree/COG1408 eggNOG ENOG4105DIN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DIN epestfind swissprot:YAEI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAEI_ECOLI garnier swissprot:YAEI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAEI_ECOLI helixturnhelix swissprot:YAEI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAEI_ECOLI hmoment swissprot:YAEI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAEI_ECOLI iep swissprot:YAEI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAEI_ECOLI inforesidue swissprot:YAEI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAEI_ECOLI octanol swissprot:YAEI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAEI_ECOLI pepcoil swissprot:YAEI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAEI_ECOLI pepdigest swissprot:YAEI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAEI_ECOLI pepinfo swissprot:YAEI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAEI_ECOLI pepnet swissprot:YAEI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAEI_ECOLI pepstats swissprot:YAEI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAEI_ECOLI pepwheel swissprot:YAEI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAEI_ECOLI pepwindow swissprot:YAEI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAEI_ECOLI sigcleave swissprot:YAEI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAEI_ECOLI ## Database ID URL or Descriptions # AltName RLMI_ECOLI 23S rRNA m5C1962 methyltransferase # AltName RLMI_ECOLI rRNA (cytosine-C(5)-)-methyltransferase RlmI # BRENDA 2.1.1.191 2026 # BioGrid 4259463 11 # CATALYTIC ACTIVITY S-adenosyl-L-methionine + cytosine(1962) in 23S rRNA = S-adenosyl-L-homocysteine + 5-methylcytosine(1962) in 23S rRNA. {ECO:0000269|PubMed 18786544}. # EcoGene EG13725 rlmI # FUNCTION RLMI_ECOLI Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA. Methylation occurs before assembly of 23S rRNA into 50S subunits. {ECO 0000269|PubMed 18786544}. # GO_component GO:0005737 cytoplasm; IC:UniProtKB. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003723 RNA binding; IEA:UniProtKB-KW. # GO_function GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity; IDA:EcoCyc. # GO_function GO:0016434 rRNA (cytosine) methyltransferase activity; IDA:UniProtKB. # GO_process GO:0031167 rRNA methylation; IDA:UniProtKB. # GO_process GO:0044010 single-species biofilm formation; IMP:EcoCyc. # GO_process GO:0070475 rRNA base methylation; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 2.30.130.10 -; 1. # Gene3D 3.40.50.150 -; 1. # HAMAP MF_01857 23SrRNA_methyltr_I # InterPro IPR002478 PUA # InterPro IPR015947 PUA-like_domain # InterPro IPR019614 SAM-dep_methyl-trfase # InterPro IPR023542 rRNA_lsu_MeTfrase_I # InterPro IPR029063 SAM-dependent_MTases # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # Organism RLMI_ECOLI Escherichia coli (strain K12) # PATRIC 32117155 VBIEscCol129921_1002 # PDB 3C0K X-ray; 2.00 A; A/B=1-396 # PIR F64837 F64837 # PROSITE PS50890 PUA # Pfam PF10672 Methyltrans_SAM # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RLMI_ECOLI Ribosomal RNA large subunit methyltransferase I # RefSeq NP_415487 NC_000913.3 # RefSeq WP_000116297 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA35732.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the methyltransferase superfamily. RlmI family. {ECO 0000305}. # SIMILARITY Contains 1 PUA domain. {ECO 0000305}. # SMART SM00359 PUA # SUBCELLULAR LOCATION RLMI_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 18789337}. # SUPFAM SSF53335 SSF53335 # SUPFAM SSF88697 SSF88697 # eggNOG COG1092 LUCA # eggNOG ENOG4105DR4 Bacteria BLAST swissprot:RLMI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RLMI_ECOLI BioCyc ECOL316407:JW5898-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5898-MONOMER BioCyc EcoCyc:G6501-MONOMER http://biocyc.org/getid?id=EcoCyc:G6501-MONOMER BioCyc MetaCyc:G6501-MONOMER http://biocyc.org/getid?id=MetaCyc:G6501-MONOMER COG COG1092 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1092 DIP DIP-11501N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11501N DOI 10.1016/j.jmb.2008.08.061 http://dx.doi.org/10.1016/j.jmb.2008.08.061 DOI 10.1016/j.jmb.2008.08.062 http://dx.doi.org/10.1016/j.jmb.2008.08.062 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.1.191 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.191 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.1.1.191 http://enzyme.expasy.org/EC/2.1.1.191 EchoBASE EB3489 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3489 EcoGene EG13725 http://www.ecogene.org/geneInfo.php?eg_id=EG13725 EnsemblBacteria AAC74053 http://www.ensemblgenomes.org/id/AAC74053 EnsemblBacteria AAC74053 http://www.ensemblgenomes.org/id/AAC74053 EnsemblBacteria BAA35732 http://www.ensemblgenomes.org/id/BAA35732 EnsemblBacteria BAA35732 http://www.ensemblgenomes.org/id/BAA35732 EnsemblBacteria BAA35732 http://www.ensemblgenomes.org/id/BAA35732 EnsemblBacteria b0967 http://www.ensemblgenomes.org/id/b0967 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0009383 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009383 GO_function GO:0016434 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016434 GO_process GO:0031167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031167 GO_process GO:0044010 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044010 GO_process GO:0070475 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070475 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 2.30.130.10 http://www.cathdb.info/version/latest/superfamily/2.30.130.10 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 GeneID 946691 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946691 HAMAP MF_01857 http://hamap.expasy.org/unirule/MF_01857 HOGENOM HOG000266009 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000266009&db=HOGENOM6 InParanoid P75876 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75876 IntEnz 2.1.1.191 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.191 InterPro IPR002478 http://www.ebi.ac.uk/interpro/entry/IPR002478 InterPro IPR015947 http://www.ebi.ac.uk/interpro/entry/IPR015947 InterPro IPR019614 http://www.ebi.ac.uk/interpro/entry/IPR019614 InterPro IPR023542 http://www.ebi.ac.uk/interpro/entry/IPR023542 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW5898 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5898 KEGG_Gene eco:b0967 http://www.genome.jp/dbget-bin/www_bget?eco:b0967 KEGG_Orthology KO:K06969 http://www.genome.jp/dbget-bin/www_bget?KO:K06969 OMA TCSCSHF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TCSCSHF PDB 3C0K http://www.ebi.ac.uk/pdbe-srv/view/entry/3C0K PDBsum 3C0K http://www.ebi.ac.uk/pdbsum/3C0K PROSITE PS50890 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50890 PSORT swissprot:RLMI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RLMI_ECOLI PSORT-B swissprot:RLMI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RLMI_ECOLI PSORT2 swissprot:RLMI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RLMI_ECOLI Pfam PF10672 http://pfam.xfam.org/family/PF10672 Phobius swissprot:RLMI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RLMI_ECOLI PhylomeDB P75876 http://phylomedb.org/?seqid=P75876 ProteinModelPortal P75876 http://www.proteinmodelportal.org/query/uniprot/P75876 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18786544 http://www.ncbi.nlm.nih.gov/pubmed/18786544 PubMed 18789337 http://www.ncbi.nlm.nih.gov/pubmed/18789337 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415487 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415487 RefSeq WP_000116297 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000116297 SMART SM00359 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00359 SMR P75876 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75876 STRING 511145.b0967 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0967&targetmode=cogs STRING COG1092 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1092&targetmode=cogs SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 SUPFAM SSF88697 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF88697 UniProtKB RLMI_ECOLI http://www.uniprot.org/uniprot/RLMI_ECOLI UniProtKB-AC P75876 http://www.uniprot.org/uniprot/P75876 charge swissprot:RLMI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RLMI_ECOLI eggNOG COG1092 http://eggnogapi.embl.de/nog_data/html/tree/COG1092 eggNOG ENOG4105DR4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DR4 epestfind swissprot:RLMI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RLMI_ECOLI garnier swissprot:RLMI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RLMI_ECOLI helixturnhelix swissprot:RLMI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RLMI_ECOLI hmoment swissprot:RLMI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RLMI_ECOLI iep swissprot:RLMI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RLMI_ECOLI inforesidue swissprot:RLMI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RLMI_ECOLI octanol swissprot:RLMI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RLMI_ECOLI pepcoil swissprot:RLMI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RLMI_ECOLI pepdigest swissprot:RLMI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RLMI_ECOLI pepinfo swissprot:RLMI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RLMI_ECOLI pepnet swissprot:RLMI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RLMI_ECOLI pepstats swissprot:RLMI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RLMI_ECOLI pepwheel swissprot:RLMI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RLMI_ECOLI pepwindow swissprot:RLMI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RLMI_ECOLI sigcleave swissprot:RLMI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RLMI_ECOLI ## Database ID URL or Descriptions # BioGrid 4259234 10 # CAUTION Could be the product of a pseudogene. A frameshift in position 87 produces two separate ORFs. {ECO 0000305}. # EcoGene EG13044 ygeN # IntAct Q46793 9 # Organism YGEN_ECOLI Escherichia coli (strain K12) # PATRIC 48665154 VBIEscCol107702_2890 # PIR B65069 B65069 # PIR C65069 C65069 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGEN_ECOLI Putative uncharacterized protein YgeN # RefSeq WP_001350544 NZ_LN832404.1 # SEQUENCE CAUTION YGEN_ECOLI Sequence=AAA83039.1; Type=Frameshift; Positions=87; Evidence={ECO 0000305}; Sequence=AAA83040.1; Type=Frameshift; Positions=87; Evidence={ECO 0000305}; Sequence=BAE76925.1; Type=Frameshift; Positions=87; Evidence={ECO 0000305}; Sequence=U00096; Type=Frameshift; Positions=87; Evidence={ECO 0000305}; BLAST swissprot:YGEN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGEN_ECOLI BioCyc ECOL316407:JW5459-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5459-MONOMER BioCyc EcoCyc:G7477-MONOMER http://biocyc.org/getid?id=EcoCyc:G7477-MONOMER BioCyc EcoCyc:G7478-MONOMER http://biocyc.org/getid?id=EcoCyc:G7478-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 EcoGene EG13044 http://www.ecogene.org/geneInfo.php?eg_id=EG13044 EnsemblBacteria BAE76925 http://www.ensemblgenomes.org/id/BAE76925 EnsemblBacteria BAE76925 http://www.ensemblgenomes.org/id/BAE76925 EnsemblBacteria BAE76925 http://www.ensemblgenomes.org/id/BAE76925 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv HOGENOM HOG000081459 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000081459&db=HOGENOM6 IntAct Q46793 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46793* KEGG_Gene ecj:JW5459 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5459 OMA NEICEHA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NEICEHA PSORT swissprot:YGEN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGEN_ECOLI PSORT-B swissprot:YGEN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGEN_ECOLI PSORT2 swissprot:YGEN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGEN_ECOLI Phobius swissprot:YGEN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGEN_ECOLI ProteinModelPortal Q46793 http://www.proteinmodelportal.org/query/uniprot/Q46793 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001350544 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001350544 SMR Q46793 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46793 STRING 316407.85675672 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85675672&targetmode=cogs UniProtKB YGEN_ECOLI http://www.uniprot.org/uniprot/YGEN_ECOLI UniProtKB-AC Q46793 http://www.uniprot.org/uniprot/Q46793 charge swissprot:YGEN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGEN_ECOLI epestfind swissprot:YGEN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGEN_ECOLI garnier swissprot:YGEN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGEN_ECOLI helixturnhelix swissprot:YGEN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGEN_ECOLI hmoment swissprot:YGEN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGEN_ECOLI iep swissprot:YGEN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGEN_ECOLI inforesidue swissprot:YGEN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGEN_ECOLI octanol swissprot:YGEN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGEN_ECOLI pepcoil swissprot:YGEN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGEN_ECOLI pepdigest swissprot:YGEN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGEN_ECOLI pepinfo swissprot:YGEN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGEN_ECOLI pepnet swissprot:YGEN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGEN_ECOLI pepstats swissprot:YGEN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGEN_ECOLI pepwheel swissprot:YGEN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGEN_ECOLI pepwindow swissprot:YGEN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGEN_ECOLI sigcleave swissprot:YGEN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGEN_ECOLI ## Database ID URL or Descriptions # AltName DEGP_ECOLI Heat shock protein DegP # AltName DEGP_ECOLI Protease Do # BIOPHYSICOCHEMICAL PROPERTIES Temperature dependence: Optimum temperature is around 55 degrees Celsius. In the range from 37 to 55 degrees Celsius, the proteolytic activity rapidly increases with temperature. {ECO 0000269|PubMed:7744744}; # BRENDA 3.4.21.107 2026 # BioGrid 4260994 924 # CATALYTIC ACTIVITY Acts on substrates that are at least partially unfolded. The cleavage site P1 residue is normally between a pair of hydrophobic residues, such as Val-|-Val. {ECO:0000269|PubMed 8830688}. # DISRUPTION PHENOTYPE DEGP_ECOLI Decreased induction of Cpx two-component regulatory system (PubMed 16166523). Increased accumulation of periplasmic accessory protein CpxP, increased accumulation and toxicity of overexpressed, misfolded periplasmic proteins (PubMed 16303867). Increased resistance to hydroxyurea, probably due to decreased degradation of misfolded proteins which eventually leads to decreased OH radical formation (PubMed 20005847). {ECO 0000269|PubMed 16166523, ECO 0000269|PubMed 16303867, ECO 0000269|PubMed 20005847}. # ENZYME REGULATION Inhibited by diisopropylfluorophosphate (DFP). {ECO:0000269|PubMed 2180903}. # EcoGene EG10463 degP # FUNCTION DEGP_ECOLI DegP acts as a chaperone at low temperatures but switches to a peptidase (heat shock protein) at higher temperatures (PubMed 10319814). Degrades transiently denatured and unfolded or misfolded proteins which accumulate in the periplasm following heat shock or other stress conditions (PubMed 16303867). DegP is efficient with Val-Xaa and Ile-Xaa peptide bonds, suggesting a preference for beta-branched side chain amino acids (PubMed 8830688). Only unfolded proteins devoid of disulfide bonds appear capable of being cleaved, thereby preventing non-specific proteolysis of folded proteins (PubMed 8830688). Its proteolytic activity is essential for the survival of cells at elevated temperatures (PubMed 7557477). It can degrade IciA, Ada, casein, globin and PapA. DegP shares specificity with DegQ (PubMed 8830688). DegP is also involved in the biogenesis of partially folded outer-membrane proteins (OMP). {ECO 0000269|PubMed 10319814, ECO 0000269|PubMed 12730160, ECO 0000269|PubMed 16303867, ECO 0000269|PubMed 18496527, ECO 0000269|PubMed 18505836, ECO 0000269|PubMed 2180903, ECO 0000269|PubMed 7557477, ECO 0000269|PubMed 8830688}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoliWiki. # GO_function GO:0004252 serine-type endopeptidase activity; IDA:EcoliWiki. # GO_process GO:0006457 protein folding; IMP:EcoliWiki. # GO_process GO:0006508 proteolysis; IDA:EcoliWiki. # GO_process GO:0006515 misfolded or incompletely synthesized protein catabolic process; IMP:EcoliWiki. # GO_process GO:0006979 response to oxidative stress; IEP:EcoliWiki. # GO_process GO:0009266 response to temperature stimulus; IEP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0008233 peptidase activity # GOslim_process GO:0006457 protein folding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # Gene3D 2.30.42.10 -; 2. # INDUCTION DEGP_ECOLI By heat shock (PubMed 3057437). Transcriptionally up- regulated by sigma-E factor and the Cpx two-component signal transduction pathway (PubMed 7883164, PubMed 9351822). {ECO 0000269|PubMed 3057437, ECO 0000269|PubMed 7883164, ECO 0000269|PubMed 9351822}. # INTERACTION DEGP_ECOLI Self; NbExp=2; IntAct=EBI-547165, EBI-547165; P00698 LYZ (xeno); NbExp=8; IntAct=EBI-547165, EBI-1029543; P0A910 ompA; NbExp=6; IntAct=EBI-547165, EBI-371347; # IntAct P0C0V0 17 # InterPro IPR001478 PDZ # InterPro IPR001940 Peptidase_S1C # InterPro IPR009003 Peptidase_S1_PA # InterPro IPR011782 Pept_S1C_Do # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # KEGG_Brite ko03110 Chaperones and folding catalysts # KEGG_Pathway ko02020 Two-component system # MISCELLANEOUS DEGP_ECOLI DegP is indispensable for bacterial survival at temperatures above 42 degrees Celsius, however is also able to digest its natural substrates in a reducing environment at temperatures as low as 20 degrees Celsius. # Organism DEGP_ECOLI Escherichia coli (strain K12) # PATRIC 32115431 VBIEscCol129921_0167 # PDB 1KY9 X-ray; 2.80 A; A/B=27-474 # PDB 2ZLE EM; 28.00 A; A/B/C/E/F/G/H/I/J/K/L/M=27-474 # PDB 3CS0 X-ray; 3.00 A; A=27-474 # PDB 3MH4 X-ray; 3.10 A; A/B=27-474 # PDB 3MH5 X-ray; 3.00 A; A/B=27-474 # PDB 3MH6 X-ray; 3.60 A; A=27-474 # PDB 3MH7 X-ray; 2.96 A; A=27-474 # PDB 3OTP X-ray; 3.76 A; A/B/C/D/E/F=27-474 # PDB 3OU0 X-ray; 3.00 A; A=27-474 # PDB 4A8D EM; 28.00 A; A/B/C/D/E/F/G/H/I/J/K/L=27-474 # PIR S45229 S45229 # PRINTS PR00834 PROTEASES2C # PROSITE PS50106 PDZ; 2 # Pfam PF00595 PDZ; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DEGP_ECOLI Periplasmic serine endoprotease DegP # RefSeq NP_414703 NC_000913.3 # RefSeq WP_000753946 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase S1C family. {ECO 0000305}. # SIMILARITY Contains 2 PDZ (DHR) domains. {ECO:0000255|PROSITE- ProRule PRU00143}. # SMART SM00228 PDZ; 2 # SUBCELLULAR LOCATION DEGP_ECOLI Cell inner membrane {ECO 0000269|PubMed 9083020}; Peripheral membrane protein {ECO 0000269|PubMed 9083020}; Cytoplasmic side {ECO 0000269|PubMed 9083020}. # SUBUNIT DEGP_ECOLI DegP can reversibly switch between different oligomeric forms that represent inactive (6-mer) and active (12-and 24-mer) protease states. Substrate binding triggers the conversion of the resting DegP trimer and hexamer into catalytically active 12- and 24-mers. The conversion of 6-mer (DegP6) into 12-mer (DegP12) or 24-mer (DegP24) is crucial in regulating protease activity. {ECO 0000269|PubMed 11919638, ECO 0000269|PubMed 18496527, ECO 0000269|PubMed 18697939, ECO 0000269|PubMed 20581825, ECO 0000269|PubMed 21458668, ECO 0000269|PubMed 21526129, ECO 0000269|PubMed 8830688}. # SUPFAM SSF50156 SSF50156; 2 # SUPFAM SSF50494 SSF50494; 2 # TIGRFAMs TIGR02037 degP_htrA_DO # eggNOG COG0265 LUCA # eggNOG ENOG4105C0H Bacteria BLAST swissprot:DEGP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DEGP_ECOLI BioCyc ECOL316407:JW0157-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0157-MONOMER BioCyc EcoCyc:EG10463-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10463-MONOMER BioCyc MetaCyc:EG10463-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10463-MONOMER COG COG0265 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0265 DIP DIP-46256N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-46256N DOI 10.1006/jmbi.1998.1726 http://dx.doi.org/10.1006/jmbi.1998.1726 DOI 10.1016/0378-1119(90)90200-B http://dx.doi.org/10.1016/0378-1119(90)90200-B DOI 10.1016/0378-1119(95)00406-V http://dx.doi.org/10.1016/0378-1119(95)00406-V DOI 10.1016/S0006-291X(05)80245-1 http://dx.doi.org/10.1016/S0006-291X(05)80245-1 DOI 10.1016/S0092-8674(00)80743-6 http://dx.doi.org/10.1016/S0092-8674(00)80743-6 DOI 10.1016/j.abb.2010.05.028 http://dx.doi.org/10.1016/j.abb.2010.05.028 DOI 10.1016/j.cell.2011.02.024 http://dx.doi.org/10.1016/j.cell.2011.02.024 DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/416455a http://dx.doi.org/10.1038/416455a DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature07004 http://dx.doi.org/10.1038/nature07004 DOI 10.1038/nsmb.1840 http://dx.doi.org/10.1038/nsmb.1840 DOI 10.1073/pnas.0508936102 http://dx.doi.org/10.1073/pnas.0508936102 DOI 10.1073/pnas.0803392105 http://dx.doi.org/10.1073/pnas.0803392105 DOI 10.1073/pnas.0805464105 http://dx.doi.org/10.1073/pnas.0805464105 DOI 10.1073/pnas.87.7.2740 http://dx.doi.org/10.1073/pnas.87.7.2740 DOI 10.1074/jbc.270.19.11140 http://dx.doi.org/10.1074/jbc.270.19.11140 DOI 10.1093/emboj/16.21.6394 http://dx.doi.org/10.1093/emboj/16.21.6394 DOI 10.1093/nar/16.21.10053 http://dx.doi.org/10.1093/nar/16.21.10053 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1101/gad.9.4.387 http://dx.doi.org/10.1101/gad.9.4.387 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.20.5762-5771.2002 http://dx.doi.org/10.1128/JB.184.20.5762-5771.2002 DOI 10.1128/JB.185.10.3020-3030.2003 http://dx.doi.org/10.1128/JB.185.10.3020-3030.2003 DOI 10.1128/JB.187.19.6622-6630.2005 http://dx.doi.org/10.1128/JB.187.19.6622-6630.2005 DOI 10.1371/journal.pone.0018944 http://dx.doi.org/10.1371/journal.pone.0018944 EC_number EC:3.4.21.107 {ECO:0000269|PubMed:8830688} http://www.genome.jp/dbget-bin/www_bget?EC:3.4.21.107 {ECO:0000269|PubMed:8830688} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M29955 http://www.ebi.ac.uk/ena/data/view/M29955 EMBL M31772 http://www.ebi.ac.uk/ena/data/view/M31772 EMBL M36536 http://www.ebi.ac.uk/ena/data/view/M36536 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EMBL X12457 http://www.ebi.ac.uk/ena/data/view/X12457 ENZYME 3.4.21.107 {ECO:0000269|PubMed:8830688} http://enzyme.expasy.org/EC/3.4.21.107 {ECO:0000269|PubMed:8830688} EchoBASE EB0458 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0458 EcoGene EG10463 http://www.ecogene.org/geneInfo.php?eg_id=EG10463 EnsemblBacteria AAC73272 http://www.ensemblgenomes.org/id/AAC73272 EnsemblBacteria AAC73272 http://www.ensemblgenomes.org/id/AAC73272 EnsemblBacteria BAB96738 http://www.ensemblgenomes.org/id/BAB96738 EnsemblBacteria BAB96738 http://www.ensemblgenomes.org/id/BAB96738 EnsemblBacteria BAB96738 http://www.ensemblgenomes.org/id/BAB96738 EnsemblBacteria b0161 http://www.ensemblgenomes.org/id/b0161 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0004252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004252 GO_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GO_process GO:0006508 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006508 GO_process GO:0006515 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006515 GO_process GO:0006979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979 GO_process GO:0009266 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009266 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 2.30.42.10 http://www.cathdb.info/version/latest/superfamily/2.30.42.10 GeneID 947139 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947139 HOGENOM HOG000223642 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000223642&db=HOGENOM6 InParanoid P0C0V0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0C0V0 IntAct P0C0V0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0C0V0* IntEnz 3.4.21.107 {ECO:0000269|PubMed:8830688} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.21.107 {ECO:0000269|PubMed:8830688} InterPro IPR001478 http://www.ebi.ac.uk/interpro/entry/IPR001478 InterPro IPR001940 http://www.ebi.ac.uk/interpro/entry/IPR001940 InterPro IPR009003 http://www.ebi.ac.uk/interpro/entry/IPR009003 InterPro IPR011782 http://www.ebi.ac.uk/interpro/entry/IPR011782 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW0157 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0157 KEGG_Gene eco:b0161 http://www.genome.jp/dbget-bin/www_bget?eco:b0161 KEGG_Orthology KO:K04771 http://www.genome.jp/dbget-bin/www_bget?KO:K04771 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 MINT MINT-1302319 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1302319 OMA QPVENIG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QPVENIG PDB 1KY9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1KY9 PDB 2ZLE http://www.ebi.ac.uk/pdbe-srv/view/entry/2ZLE PDB 3CS0 http://www.ebi.ac.uk/pdbe-srv/view/entry/3CS0 PDB 3MH4 http://www.ebi.ac.uk/pdbe-srv/view/entry/3MH4 PDB 3MH5 http://www.ebi.ac.uk/pdbe-srv/view/entry/3MH5 PDB 3MH6 http://www.ebi.ac.uk/pdbe-srv/view/entry/3MH6 PDB 3MH7 http://www.ebi.ac.uk/pdbe-srv/view/entry/3MH7 PDB 3OTP http://www.ebi.ac.uk/pdbe-srv/view/entry/3OTP PDB 3OU0 http://www.ebi.ac.uk/pdbe-srv/view/entry/3OU0 PDB 4A8D http://www.ebi.ac.uk/pdbe-srv/view/entry/4A8D PDBsum 1KY9 http://www.ebi.ac.uk/pdbsum/1KY9 PDBsum 2ZLE http://www.ebi.ac.uk/pdbsum/2ZLE PDBsum 3CS0 http://www.ebi.ac.uk/pdbsum/3CS0 PDBsum 3MH4 http://www.ebi.ac.uk/pdbsum/3MH4 PDBsum 3MH5 http://www.ebi.ac.uk/pdbsum/3MH5 PDBsum 3MH6 http://www.ebi.ac.uk/pdbsum/3MH6 PDBsum 3MH7 http://www.ebi.ac.uk/pdbsum/3MH7 PDBsum 3OTP http://www.ebi.ac.uk/pdbsum/3OTP PDBsum 3OU0 http://www.ebi.ac.uk/pdbsum/3OU0 PDBsum 4A8D http://www.ebi.ac.uk/pdbsum/4A8D PRINTS PR00834 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00834 PROSITE PS50106 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50106 PSORT swissprot:DEGP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DEGP_ECOLI PSORT-B swissprot:DEGP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DEGP_ECOLI PSORT2 swissprot:DEGP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DEGP_ECOLI Pfam PF00595 http://pfam.xfam.org/family/PF00595 Phobius swissprot:DEGP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DEGP_ECOLI PhylomeDB P0C0V0 http://phylomedb.org/?seqid=P0C0V0 ProteinModelPortal P0C0V0 http://www.proteinmodelportal.org/query/uniprot/P0C0V0 PubMed 10319814 http://www.ncbi.nlm.nih.gov/pubmed/10319814 PubMed 11919638 http://www.ncbi.nlm.nih.gov/pubmed/11919638 PubMed 12270835 http://www.ncbi.nlm.nih.gov/pubmed/12270835 PubMed 12730160 http://www.ncbi.nlm.nih.gov/pubmed/12730160 PubMed 12878036 http://www.ncbi.nlm.nih.gov/pubmed/12878036 PubMed 16166523 http://www.ncbi.nlm.nih.gov/pubmed/16166523 PubMed 16303867 http://www.ncbi.nlm.nih.gov/pubmed/16303867 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18496527 http://www.ncbi.nlm.nih.gov/pubmed/18496527 PubMed 18505836 http://www.ncbi.nlm.nih.gov/pubmed/18505836 PubMed 18697939 http://www.ncbi.nlm.nih.gov/pubmed/18697939 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 2025286 http://www.ncbi.nlm.nih.gov/pubmed/2025286 PubMed 20515644 http://www.ncbi.nlm.nih.gov/pubmed/20515644 PubMed 20581825 http://www.ncbi.nlm.nih.gov/pubmed/20581825 PubMed 21458668 http://www.ncbi.nlm.nih.gov/pubmed/21458668 PubMed 21526129 http://www.ncbi.nlm.nih.gov/pubmed/21526129 PubMed 2157212 http://www.ncbi.nlm.nih.gov/pubmed/2157212 PubMed 2165018 http://www.ncbi.nlm.nih.gov/pubmed/2165018 PubMed 2180903 http://www.ncbi.nlm.nih.gov/pubmed/2180903 PubMed 3057437 http://www.ncbi.nlm.nih.gov/pubmed/3057437 PubMed 7557477 http://www.ncbi.nlm.nih.gov/pubmed/7557477 PubMed 7744744 http://www.ncbi.nlm.nih.gov/pubmed/7744744 PubMed 7883164 http://www.ncbi.nlm.nih.gov/pubmed/7883164 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 8830688 http://www.ncbi.nlm.nih.gov/pubmed/8830688 PubMed 9083020 http://www.ncbi.nlm.nih.gov/pubmed/9083020 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9351822 http://www.ncbi.nlm.nih.gov/pubmed/9351822 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 RefSeq NP_414703 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414703 RefSeq WP_000753946 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000753946 SMART SM00228 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00228 SMR P0C0V0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0C0V0 STRING 511145.b0161 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0161&targetmode=cogs STRING COG0265 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0265&targetmode=cogs SUPFAM SSF50156 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50156 SUPFAM SSF50494 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50494 SWISS-2DPAGE P0C0V0 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0C0V0 TIGRFAMs TIGR02037 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02037 UniProtKB DEGP_ECOLI http://www.uniprot.org/uniprot/DEGP_ECOLI UniProtKB-AC P0C0V0 http://www.uniprot.org/uniprot/P0C0V0 charge swissprot:DEGP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DEGP_ECOLI eggNOG COG0265 http://eggnogapi.embl.de/nog_data/html/tree/COG0265 eggNOG ENOG4105C0H http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C0H epestfind swissprot:DEGP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DEGP_ECOLI garnier swissprot:DEGP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DEGP_ECOLI helixturnhelix swissprot:DEGP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DEGP_ECOLI hmoment swissprot:DEGP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DEGP_ECOLI iep swissprot:DEGP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DEGP_ECOLI inforesidue swissprot:DEGP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DEGP_ECOLI octanol swissprot:DEGP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DEGP_ECOLI pepcoil swissprot:DEGP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DEGP_ECOLI pepdigest swissprot:DEGP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DEGP_ECOLI pepinfo swissprot:DEGP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DEGP_ECOLI pepnet swissprot:DEGP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DEGP_ECOLI pepstats swissprot:DEGP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DEGP_ECOLI pepwheel swissprot:DEGP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DEGP_ECOLI pepwindow swissprot:DEGP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DEGP_ECOLI sigcleave swissprot:DEGP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DEGP_ECOLI ## Database ID URL or Descriptions # AltName GABP_ECOLI 4-amino butyrate transport carrier # AltName GABP_ECOLI Gamma-aminobutyrate permease # BioGrid 4261470 17 # EcoGene EG11330 gabP # FUNCTION GABP_ECOLI Transporter for GABA. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0015179 L-amino acid transmembrane transporter activity; IBA:GO_Central. # GO_function GO:0015185 gamma-aminobutyric acid transmembrane transporter activity; IEA:InterPro. # GO_function GO:0015297 antiporter activity; IBA:GO_Central. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0009450 gamma-aminobutyric acid catabolic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009056 catabolic process # INDUCTION Induced by RpoS, but not in response to multiple stress conditions. {ECO:0000269|PubMed 14731280}. # IntAct P25527 2 # InterPro IPR002293 AA/rel_permease1 # InterPro IPR004840 Amoino_acid_permease_CS # InterPro IPR004841 AA-permease/SLC12A_dom # InterPro IPR011265 GABA_permease # KEGG_Brite ko02000 Transporters # Organism GABP_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11785 PTHR11785 # PATHWAY GABP_ECOLI Amino-acid degradation; 4-aminobutanoate degradation. # PATRIC 32120716 VBIEscCol129921_2755 # PIR H65045 H65045 # PIRSF PIRSF006060 AA_transporter # PROSITE PS00218 AMINO_ACID_PERMEASE_1 # Pfam PF00324 AA_permease # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GABP_ECOLI GABA permease # RefSeq NP_417149 NC_000913.3 # RefSeq WP_001295173 NZ_LN832404.1 # SIMILARITY Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family. {ECO 0000305}. # SUBCELLULAR LOCATION GABP_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.3.1 the amino acid-polyamine-organocation (apc) family # TIGRFAMs TIGR01773 GABAperm # eggNOG COG1113 LUCA # eggNOG ENOG4105C85 Bacteria BLAST swissprot:GABP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GABP_ECOLI BioCyc ECOL316407:JW2638-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2638-MONOMER BioCyc EcoCyc:GABP-MONOMER http://biocyc.org/getid?id=EcoCyc:GABP-MONOMER BioCyc MetaCyc:GABP-MONOMER http://biocyc.org/getid?id=MetaCyc:GABP-MONOMER COG COG1113 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1113 DIP DIP-9724N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9724N DOI 10.1007/BF00245306 http://dx.doi.org/10.1007/BF00245306 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2003.03867.x http://dx.doi.org/10.1046/j.1365-2958.2003.03867.x DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M88334 http://www.ebi.ac.uk/ena/data/view/M88334 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X65104 http://www.ebi.ac.uk/ena/data/view/X65104 EchoBASE EB1306 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1306 EcoGene EG11330 http://www.ecogene.org/geneInfo.php?eg_id=EG11330 EnsemblBacteria AAC75710 http://www.ensemblgenomes.org/id/AAC75710 EnsemblBacteria AAC75710 http://www.ensemblgenomes.org/id/AAC75710 EnsemblBacteria BAA16526 http://www.ensemblgenomes.org/id/BAA16526 EnsemblBacteria BAA16526 http://www.ensemblgenomes.org/id/BAA16526 EnsemblBacteria BAA16526 http://www.ensemblgenomes.org/id/BAA16526 EnsemblBacteria b2663 http://www.ensemblgenomes.org/id/b2663 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015179 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015179 GO_function GO:0015185 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015185 GO_function GO:0015297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015297 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0009450 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009450 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GeneID 948049 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948049 HOGENOM HOG000261846 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261846&db=HOGENOM6 InParanoid P25527 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P25527 IntAct P25527 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P25527* InterPro IPR002293 http://www.ebi.ac.uk/interpro/entry/IPR002293 InterPro IPR004840 http://www.ebi.ac.uk/interpro/entry/IPR004840 InterPro IPR004841 http://www.ebi.ac.uk/interpro/entry/IPR004841 InterPro IPR011265 http://www.ebi.ac.uk/interpro/entry/IPR011265 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2638 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2638 KEGG_Gene eco:b2663 http://www.genome.jp/dbget-bin/www_bget?eco:b2663 KEGG_Orthology KO:K11735 http://www.genome.jp/dbget-bin/www_bget?KO:K11735 MINT MINT-1248489 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1248489 OMA FENARHI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FENARHI PANTHER PTHR11785 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11785 PROSITE PS00218 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00218 PSORT swissprot:GABP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GABP_ECOLI PSORT-B swissprot:GABP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GABP_ECOLI PSORT2 swissprot:GABP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GABP_ECOLI Pfam PF00324 http://pfam.xfam.org/family/PF00324 Phobius swissprot:GABP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GABP_ECOLI PhylomeDB P25527 http://phylomedb.org/?seqid=P25527 ProteinModelPortal P25527 http://www.proteinmodelportal.org/query/uniprot/P25527 PubMed 14731280 http://www.ncbi.nlm.nih.gov/pubmed/14731280 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8297211 http://www.ncbi.nlm.nih.gov/pubmed/8297211 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417149 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417149 RefSeq WP_001295173 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295173 STRING 511145.b2663 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2663&targetmode=cogs STRING COG1113 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1113&targetmode=cogs TCDB 2.A.3.1 http://www.tcdb.org/search/result.php?tc=2.A.3.1 TIGRFAMs TIGR01773 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01773 UniProtKB GABP_ECOLI http://www.uniprot.org/uniprot/GABP_ECOLI UniProtKB-AC P25527 http://www.uniprot.org/uniprot/P25527 charge swissprot:GABP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GABP_ECOLI eggNOG COG1113 http://eggnogapi.embl.de/nog_data/html/tree/COG1113 eggNOG ENOG4105C85 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C85 epestfind swissprot:GABP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GABP_ECOLI garnier swissprot:GABP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GABP_ECOLI helixturnhelix swissprot:GABP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GABP_ECOLI hmoment swissprot:GABP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GABP_ECOLI iep swissprot:GABP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GABP_ECOLI inforesidue swissprot:GABP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GABP_ECOLI octanol swissprot:GABP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GABP_ECOLI pepcoil swissprot:GABP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GABP_ECOLI pepdigest swissprot:GABP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GABP_ECOLI pepinfo swissprot:GABP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GABP_ECOLI pepnet swissprot:GABP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GABP_ECOLI pepstats swissprot:GABP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GABP_ECOLI pepwheel swissprot:GABP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GABP_ECOLI pepwindow swissprot:GABP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GABP_ECOLI sigcleave swissprot:GABP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GABP_ECOLI ## Database ID URL or Descriptions # AltName PUUC_ECOLI 3-hydroxypropionaldehyde dehydrogenase # AltName PUUC_ECOLI Gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase # BIOPHYSICOCHEMICAL PROPERTIES PUUC_ECOLI Kinetic parameters KM=0.06 mM for 3-hydroxypropionaldehyde (with NAD at ph 8 and at 37 degrees Celsius) {ECO 0000269|PubMed 18668238}; KM=0.12 mM for 3-hydroxypropionic acid (with NADH at ph 8 and at 37 degrees Celsius) {ECO 0000269|PubMed 18668238}; KM=0.24 mM for valeraldehyde (with NAD at ph 8 and at 37 degrees Celsius) {ECO 0000269|PubMed 18668238}; KM=0.29 mM for 3-hydroxypropionaldehyde (with NADP at ph 8 and at 37 degrees Celsius) {ECO 0000269|PubMed 18668238}; KM=0.49 mM for 3-hydroxypropionaldehyde (with NAD at ph 8 and at 37 degrees Celsius) {ECO 0000269|PubMed 18668238}; KM=0.68 mM for isovaleraldehyde (with NAD at ph 8 and at 37 degrees Celsius) {ECO 0000269|PubMed 18668238}; KM=0.97 mM for butyraldehyde (with NAD at ph 8 and at 37 degrees Celsius) {ECO 0000269|PubMed 18668238}; KM=1.00 mM for acetaldehyde (with NAD at ph 8 and at 37 degrees Celsius) {ECO 0000269|PubMed 18668238}; KM=1.21 mM for propionaldehyde (with NAD at ph 8 and at 37 degrees Celsius) {ECO 0000269|PubMed 18668238}; KM=5.37 mM for benzaldehyde (with NADP at ph 8 and at 37 degrees Celsius) {ECO 0000269|PubMed 18668238}; Vmax=0.3 umol/min/mg enzyme with 3-hydroxypropionic acid as substrate (with NADH at ph 8 and at 37 degrees Celsius) {ECO 0000269|PubMed 18668238}; Vmax=5.5 umol/min/mg enzyme with 3-hydroxypropionaldehyde as substrate (with NADP at ph 8 and at 37 degrees Celsius) {ECO 0000269|PubMed 18668238}; Vmax=12.39 umol/min/mg enzyme with acetaldehyde as substrate (with NAD at ph 8 and at 37 degrees Celsius) {ECO 0000269|PubMed 18668238}; Vmax=19.51 umol/min/mg enzyme with benzaldehyde as substrate (with NADP at ph 8 and at 37 degrees Celsius) {ECO 0000269|PubMed 18668238}; Vmax=27.35 umol/min/mg enzyme with propionaldehyde as substrate (with NAD at ph 8 and at 37 degrees Celsius) {ECO 0000269|PubMed 18668238}; Vmax=29.47 umol/min/mg enzyme with valeraldehyde as substrate (with NAD at ph 8 and at 37 degrees Celsius) {ECO 0000269|PubMed 18668238}; Vmax=30.07 umol/min/mg enzyme with butyraldehyde as substrate (with NAD at ph 8 and at 37 degrees Celsius) {ECO 0000269|PubMed 18668238}; Vmax=30.10 umol/min/mg enzyme with 3-hydroxypropionaldehyde as substrate (with NAD at ph 8 and at 37 degrees Celsius) {ECO 0000269|PubMed 18668238}; Vmax=30.67 umol/min/mg enzyme with isovaleraldehyde as substrate (with NAD at ph 8 and at 37 degrees Celsius) {ECO 0000269|PubMed 18668238}; Vmax=32.1 umol/min/mg enzyme with 3-hydroxypropionaldehyde as substrate (with NAD at ph 8 and at 37 degrees Celsius) {ECO 0000269|PubMed 18668238}; pH dependence Optimum pH is 8. Activity is highly sensitive to pH variation, and an increase or decrease of one pH unit from the optimal attenuates more than 70% of activity. At pH 6.0, only 6% of the activity remains. At pH.5.0, the activity is completely abolished. {ECO 0000269|PubMed 18668238}; Temperature dependence Optimum temperature is 37 degrees Celsius. It appears to be stable between 20 and 50 degrees Celsius but becomes very unstable at or above 50 degrees Celsius. {ECO 0000269|PubMed 18668238}; # BRENDA 1.2.1.B6 2026 # BioGrid 4263528 7 # CATALYTIC ACTIVITY PUUC_ECOLI An aldehyde + NAD(P)(+) + H(2)O = a carboxylate + NAD(P)H. # CATALYTIC ACTIVITY PUUC_ECOLI Gamma-glutamyl-gamma-aminobutyraldehyde + NAD(+) + H(2)O = gamma-glutamyl-gamma-aminobutyrate + NADH. # ENZYME REGULATION Lithium ions exhibits the highest inhibition (97%). To a lesser extent (5-20%), potassium, sodium, and ammonium ions also inhibit PuuC activity. Transition metals, such as copper and zinc ions inhibit PuuC activity by more than 90%. The presence of heavy metals (mercury, silver) or sodium hydrogensulfite in the reaction mixture completely inactivate PuuC; in contrast, disulfide reductants such as DTT and 2-mercaptoethanol significantly increase its activity by 75% and 27%, respectively. {ECO:0000269|PubMed 18668238}. # EcoGene EG10036 puuC # FUNCTION PUUC_ECOLI Catalyzes the oxidation of 3-hydroxypropionaldehyde (3- HPA) to 3-hydroxypropionic acid (3-HP). It acts preferentially with NAD but can also use NADP. 3-HPA appears to be the most suitable substrate for PuuC followed by isovaleraldehyde, propionaldehyde, butyraldehyde, and valeraldehyde. It might play a role in propionate and/or acetic acid metabolisms. Also involved in the breakdown of putrescine through the oxidation of gamma-Glu- gamma-aminobutyraldehyde to gamma-Glu-gamma-aminobutyrate (gamma- Glu-GABA). {ECO 0000269|PubMed 15590624, ECO 0000269|PubMed 18668238}. # GO_function GO:0004029 aldehyde dehydrogenase (NAD) activity; IBA:GO_Central. # GO_function GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity; IDA:EcoCyc. # GO_process GO:0009447 putrescine catabolic process; IMP:EcoCyc. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.309.10 -; 1. # Gene3D 3.40.605.10 -; 1. # InterPro IPR015590 Aldehyde_DH_dom # InterPro IPR016160 Ald_DH_CS_CYS # InterPro IPR016161 Ald_DH/histidinol_DH # InterPro IPR016162 Ald_DH_N # InterPro IPR016163 Ald_DH_C # InterPro IPR029510 Ald_DH_CS_GLU # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00330 Arginine and proline metabolism # Organism PUUC_ECOLI Escherichia coli (strain K12) # PATHWAY Amine and polyamine degradation; putrescine degradation; 4-aminobutanoate from putrescine step 3/4. # PATRIC 32117872 VBIEscCol129921_1356 # PIR G64878 G64878 # PROSITE PS00070 ALDEHYDE_DEHYDR_CYS # PROSITE PS00687 ALDEHYDE_DEHYDR_GLU # Pfam PF00171 Aldedh # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PUUC_ECOLI Aldehyde dehydrogenase PuuC # RefSeq NP_415816 NC_000913.3 # RefSeq WP_001009090 NZ_LN832404.1 # SIMILARITY Belongs to the aldehyde dehydrogenase family. {ECO 0000305}. # SUPFAM SSF53720 SSF53720 # UniPathway UPA00188 UER00882 # eggNOG COG1012 LUCA # eggNOG ENOG4105C26 Bacteria BLAST swissprot:PUUC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PUUC_ECOLI BioCyc ECOL316407:JW1293-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1293-MONOMER BioCyc EcoCyc:ALDHDEHYDROG-MONOMER http://biocyc.org/getid?id=EcoCyc:ALDHDEHYDROG-MONOMER BioCyc MetaCyc:ALDHDEHYDROG-MONOMER http://biocyc.org/getid?id=MetaCyc:ALDHDEHYDROG-MONOMER COG COG1012 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1012 DIP DIP-9083N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9083N DOI 10.1007/s00253-008-1608-x http://dx.doi.org/10.1007/s00253-008-1608-x DOI 10.1016/0378-1119(91)90028-A http://dx.doi.org/10.1016/0378-1119(91)90028-A DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M411114200 http://dx.doi.org/10.1074/jbc.M411114200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.2.1.5 http://www.genome.jp/dbget-bin/www_bget?EC:1.2.1.5 EMBL AB200319 http://www.ebi.ac.uk/ena/data/view/AB200319 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M38433 http://www.ebi.ac.uk/ena/data/view/M38433 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.2.1.5 http://enzyme.expasy.org/EC/1.2.1.5 EchoBASE EB0035 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0035 EcoGene EG10036 http://www.ecogene.org/geneInfo.php?eg_id=EG10036 EnsemblBacteria AAC74382 http://www.ensemblgenomes.org/id/AAC74382 EnsemblBacteria AAC74382 http://www.ensemblgenomes.org/id/AAC74382 EnsemblBacteria BAA14869 http://www.ensemblgenomes.org/id/BAA14869 EnsemblBacteria BAA14869 http://www.ensemblgenomes.org/id/BAA14869 EnsemblBacteria BAA14869 http://www.ensemblgenomes.org/id/BAA14869 EnsemblBacteria b1300 http://www.ensemblgenomes.org/id/b1300 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004029 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004029 GO_function GO:0004030 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004030 GO_process GO:0009447 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009447 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.309.10 http://www.cathdb.info/version/latest/superfamily/3.40.309.10 Gene3D 3.40.605.10 http://www.cathdb.info/version/latest/superfamily/3.40.605.10 GeneID 947003 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947003 HOGENOM HOG000271505 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000271505&db=HOGENOM6 InParanoid P23883 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23883 IntEnz 1.2.1.5 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.2.1.5 InterPro IPR015590 http://www.ebi.ac.uk/interpro/entry/IPR015590 InterPro IPR016160 http://www.ebi.ac.uk/interpro/entry/IPR016160 InterPro IPR016161 http://www.ebi.ac.uk/interpro/entry/IPR016161 InterPro IPR016162 http://www.ebi.ac.uk/interpro/entry/IPR016162 InterPro IPR016163 http://www.ebi.ac.uk/interpro/entry/IPR016163 InterPro IPR029510 http://www.ebi.ac.uk/interpro/entry/IPR029510 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1293 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1293 KEGG_Gene eco:b1300 http://www.genome.jp/dbget-bin/www_bget?eco:b1300 KEGG_Orthology KO:K09472 http://www.genome.jp/dbget-bin/www_bget?KO:K09472 KEGG_Pathway ko00330 http://www.genome.jp/kegg-bin/show_pathway?ko00330 KEGG_Reaction rn:R07417 http://www.genome.jp/dbget-bin/www_bget?rn:R07417 KEGG_Reaction rn:R07418 http://www.genome.jp/dbget-bin/www_bget?rn:R07418 OMA KTIWIAL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KTIWIAL PROSITE PS00070 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00070 PROSITE PS00687 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00687 PSORT swissprot:PUUC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PUUC_ECOLI PSORT-B swissprot:PUUC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PUUC_ECOLI PSORT2 swissprot:PUUC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PUUC_ECOLI Pfam PF00171 http://pfam.xfam.org/family/PF00171 Phobius swissprot:PUUC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PUUC_ECOLI PhylomeDB P23883 http://phylomedb.org/?seqid=P23883 ProteinModelPortal P23883 http://www.proteinmodelportal.org/query/uniprot/P23883 PubMed 15590624 http://www.ncbi.nlm.nih.gov/pubmed/15590624 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1840553 http://www.ncbi.nlm.nih.gov/pubmed/1840553 PubMed 18668238 http://www.ncbi.nlm.nih.gov/pubmed/18668238 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415816 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415816 RefSeq WP_001009090 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001009090 SMR P23883 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P23883 STRING 511145.b1300 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1300&targetmode=cogs STRING COG1012 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1012&targetmode=cogs SUPFAM SSF53720 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53720 UniProtKB PUUC_ECOLI http://www.uniprot.org/uniprot/PUUC_ECOLI UniProtKB-AC P23883 http://www.uniprot.org/uniprot/P23883 charge swissprot:PUUC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PUUC_ECOLI eggNOG COG1012 http://eggnogapi.embl.de/nog_data/html/tree/COG1012 eggNOG ENOG4105C26 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C26 epestfind swissprot:PUUC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PUUC_ECOLI garnier swissprot:PUUC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PUUC_ECOLI helixturnhelix swissprot:PUUC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PUUC_ECOLI hmoment swissprot:PUUC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PUUC_ECOLI iep swissprot:PUUC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PUUC_ECOLI inforesidue swissprot:PUUC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PUUC_ECOLI octanol swissprot:PUUC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PUUC_ECOLI pepcoil swissprot:PUUC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PUUC_ECOLI pepdigest swissprot:PUUC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PUUC_ECOLI pepinfo swissprot:PUUC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PUUC_ECOLI pepnet swissprot:PUUC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PUUC_ECOLI pepstats swissprot:PUUC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PUUC_ECOLI pepwheel swissprot:PUUC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PUUC_ECOLI pepwindow swissprot:PUUC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PUUC_ECOLI sigcleave swissprot:PUUC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PUUC_ECOLI ## Database ID URL or Descriptions # AltName SUCP_ECOLI Sucrose glucosyltransferase # BioGrid 4263230 11 # CATALYTIC ACTIVITY SUCP_ECOLI Sucrose + phosphate = D-fructose + alpha-D- glucose 1-phosphate. # CAZy GH13 Glycoside Hydrolase Family 13 # CDD cd11356 AmyAc_Sucrose_phosphorylase-li # EcoGene EG13910 ycjM # GO_function GO:0009018 sucrose phosphorylase activity; IEA:UniProtKB-EC. # GO_process GO:0005985 sucrose metabolic process; IEA:InterPro. # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_process GO:0005975 carbohydrate metabolic process # Gene3D 2.60.40.1180 -; 1. # Gene3D 3.20.20.80 -; 2. # IntAct P76041 2 # InterPro IPR006047 Glyco_hydro_13_cat_dom # InterPro IPR013780 Glyco_hydro_b # InterPro IPR013781 Glyco_hydro_catalytic_dom # InterPro IPR015902 Glyco_hydro_13 # InterPro IPR016377 Sucrose_phosphorylase-rel # InterPro IPR017853 Glycoside_hydrolase_SF # InterPro IPR033746 Sucrose_Prylase_YcjM # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00500 Starch and sucrose metabolism # Organism SUCP_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10357 PTHR10357; 2 # PATRIC 32117890 VBIEscCol129921_1365 # PIR H64879 H64879 # PIRSF PIRSF003059 Sucrose_phosphorylase # Pfam PF00128 Alpha-amylase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SUCP_ECOLI Putative sucrose phosphorylase # RefSeq NP_415825 NC_000913.3 # RefSeq WP_000810499 NZ_LN832404.1 # SIMILARITY Belongs to the sucrose phosphorylase family. {ECO 0000305}. # SMART SM00642 Aamy # SUPFAM SSF51445 SSF51445; 2 # eggNOG COG0366 LUCA # eggNOG ENOG4107QW3 Bacteria BLAST swissprot:SUCP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SUCP_ECOLI BioCyc ECOL316407:JW1302-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1302-MONOMER BioCyc EcoCyc:G6647-MONOMER http://biocyc.org/getid?id=EcoCyc:G6647-MONOMER COG COG0366 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0366 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.4.1.7 http://www.genome.jp/dbget-bin/www_bget?EC:2.4.1.7 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.4.1.7 http://enzyme.expasy.org/EC/2.4.1.7 EchoBASE EB3669 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3669 EcoGene EG13910 http://www.ecogene.org/geneInfo.php?eg_id=EG13910 EnsemblBacteria AAC74391 http://www.ensemblgenomes.org/id/AAC74391 EnsemblBacteria AAC74391 http://www.ensemblgenomes.org/id/AAC74391 EnsemblBacteria BAA14886 http://www.ensemblgenomes.org/id/BAA14886 EnsemblBacteria BAA14886 http://www.ensemblgenomes.org/id/BAA14886 EnsemblBacteria BAA14886 http://www.ensemblgenomes.org/id/BAA14886 EnsemblBacteria b1309 http://www.ensemblgenomes.org/id/b1309 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0009018 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009018 GO_process GO:0005985 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005985 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 Gene3D 2.60.40.1180 http://www.cathdb.info/version/latest/superfamily/2.60.40.1180 Gene3D 3.20.20.80 http://www.cathdb.info/version/latest/superfamily/3.20.20.80 GeneID 945659 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945659 HOGENOM HOG000089743 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000089743&db=HOGENOM6 InParanoid P76041 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76041 IntAct P76041 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76041* IntEnz 2.4.1.7 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.1.7 InterPro IPR006047 http://www.ebi.ac.uk/interpro/entry/IPR006047 InterPro IPR013780 http://www.ebi.ac.uk/interpro/entry/IPR013780 InterPro IPR013781 http://www.ebi.ac.uk/interpro/entry/IPR013781 InterPro IPR015902 http://www.ebi.ac.uk/interpro/entry/IPR015902 InterPro IPR016377 http://www.ebi.ac.uk/interpro/entry/IPR016377 InterPro IPR017853 http://www.ebi.ac.uk/interpro/entry/IPR017853 InterPro IPR033746 http://www.ebi.ac.uk/interpro/entry/IPR033746 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1302 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1302 KEGG_Gene eco:b1309 http://www.genome.jp/dbget-bin/www_bget?eco:b1309 KEGG_Orthology KO:K00690 http://www.genome.jp/dbget-bin/www_bget?KO:K00690 KEGG_Pathway ko00500 http://www.genome.jp/kegg-bin/show_pathway?ko00500 KEGG_Reaction rn:R00803 http://www.genome.jp/dbget-bin/www_bget?rn:R00803 OMA ANTHGES http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ANTHGES PANTHER PTHR10357 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10357 PSORT swissprot:SUCP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SUCP_ECOLI PSORT-B swissprot:SUCP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SUCP_ECOLI PSORT2 swissprot:SUCP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SUCP_ECOLI Pfam PF00128 http://pfam.xfam.org/family/PF00128 Phobius swissprot:SUCP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SUCP_ECOLI PhylomeDB P76041 http://phylomedb.org/?seqid=P76041 ProteinModelPortal P76041 http://www.proteinmodelportal.org/query/uniprot/P76041 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415825 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415825 RefSeq WP_000810499 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000810499 SMART SM00642 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00642 STRING 511145.b1309 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1309&targetmode=cogs STRING COG0366 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0366&targetmode=cogs SUPFAM SSF51445 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51445 UniProtKB SUCP_ECOLI http://www.uniprot.org/uniprot/SUCP_ECOLI UniProtKB-AC P76041 http://www.uniprot.org/uniprot/P76041 charge swissprot:SUCP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SUCP_ECOLI eggNOG COG0366 http://eggnogapi.embl.de/nog_data/html/tree/COG0366 eggNOG ENOG4107QW3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QW3 epestfind swissprot:SUCP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SUCP_ECOLI garnier swissprot:SUCP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SUCP_ECOLI helixturnhelix swissprot:SUCP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SUCP_ECOLI hmoment swissprot:SUCP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SUCP_ECOLI iep swissprot:SUCP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SUCP_ECOLI inforesidue swissprot:SUCP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SUCP_ECOLI octanol swissprot:SUCP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SUCP_ECOLI pepcoil swissprot:SUCP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SUCP_ECOLI pepdigest swissprot:SUCP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SUCP_ECOLI pepinfo swissprot:SUCP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SUCP_ECOLI pepnet swissprot:SUCP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SUCP_ECOLI pepstats swissprot:SUCP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SUCP_ECOLI pepwheel swissprot:SUCP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SUCP_ECOLI pepwindow swissprot:SUCP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SUCP_ECOLI sigcleave swissprot:SUCP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SUCP_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES DAPB_ECOLI Kinetic parameters KM=1.6 uM for NADH {ECO 0000269|PubMed 7893644, ECO 0000269|PubMed 9398235}; KM=8 uM for NADPH {ECO 0000269|PubMed 7893644, ECO 0000269|PubMed 9398235}; # BRENDA 1.17.1 2026 # CATALYTIC ACTIVITY DAPB_ECOLI (S)-2,3,4,5-tetrahydropyridine-2,6- dicarboxylate + NAD(P)(+) + H(2)O = (2S,4S)-4-hydroxy-2,3,4,5- tetrahydrodipicolinate + NAD(P)H. {ECO 0000255|HAMAP- Rule MF_00102, ECO 0000269|PubMed 20503968}. # CAUTION Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5- tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction (PubMed:20503968). {ECO 0000305|PubMed:20503968}. # ENZYME REGULATION Is inhibited by 2,6-pyridine dicarboxylate (2,6-PDC or picolinate). {ECO:0000269|PubMed 9398235}. # EcoGene EG10206 dapB # FUNCTION DAPB_ECOLI Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. Can use both NADH and NADPH as a reductant, with NADH being twice as effective as NADPH. {ECO 0000255|HAMAP-Rule MF_00102, ECO 0000269|PubMed 20503968, ECO 0000269|PubMed 7893644}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0008839 4-hydroxy-tetrahydrodipicolinate reductase; IDA:EcoCyc. # GO_function GO:0016726 oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor; IEA:UniProtKB-HAMAP. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0050661 NADP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0051287 NAD binding; IEA:UniProtKB-HAMAP. # GO_process GO:0008652 cellular amino acid biosynthetic process; IDA:EcoliWiki. # GO_process GO:0009089 lysine biosynthetic process via diaminopimelate; IEA:UniProtKB-HAMAP. # GO_process GO:0019877 diaminopimelate biosynthetic process; IDA:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.720 -; 1. # HAMAP MF_00102 DapB # INDUCTION Expression of dapB is up-regulated by ArgP and is repressed by lysine that prevents the binding of the ArgP activator. Thus, ArgP contributes to enhanced transcription of dapB when lysine becomes limiting. {ECO:0000269|PubMed 18502871}. # InterPro IPR000846 DapB_N # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR022663 DapB_C # InterPro IPR022664 DapB_N_CS # InterPro IPR023940 DHDPR_bac # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00300 Lysine biosynthesis # MASS SPECTROMETRY Mass=28758; Mass_error=8; Method=Electrospray; Range=1-273; Evidence={ECO:0000269|PubMed 7893644}; # Organism DAPB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR20836 PTHR20836 # PATHWAY Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4. {ECO 0000255|HAMAP-Rule:MF_00102}. # PATRIC 32115153 VBIEscCol129921_0028 # PDB 1ARZ X-ray; 2.60 A; A/B/C/D=1-273 # PDB 1DIH X-ray; 2.20 A; A=1-273 # PDB 1DRU X-ray; 2.20 A; A=1-273 # PDB 1DRV X-ray; 2.20 A; A=1-273 # PDB 1DRW X-ray; 2.20 A; A=1-273 # PIR A00375 RDECPD # PIRSF PIRSF000161 DHPR # PROSITE PS01298 DAPB # Pfam PF01113 DapB_N # Pfam PF05173 DapB_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 4-hydroxy-tetrahydrodipicolinate reductase {ECO:0000255|HAMAP-Rule MF_00102} # RefSeq NP_414572 NC_000913.3 # RefSeq WP_000543604 NZ_LN832404.1 # SIMILARITY Belongs to the DapB family. {ECO:0000255|HAMAP- Rule MF_00102}. # SUBCELLULAR LOCATION DAPB_ECOLI Cytoplasm. # SUBUNIT DAPB_ECOLI Homotetramer. {ECO 0000255|HAMAP-Rule MF_00102, ECO 0000269|PubMed 7893644, ECO 0000269|PubMed 7893645, ECO 0000269|PubMed 8873595, ECO 0000269|PubMed 9398235}. # SUPFAM SSF51735 SSF51735; 2 # TIGRFAMs TIGR00036 dapB # UniPathway UPA00034 UER00018 # eggNOG COG0289 LUCA # eggNOG ENOG4105DUK Bacteria BLAST swissprot:DAPB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DAPB_ECOLI BioCyc ECOL316407:JW0029-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0029-MONOMER BioCyc EcoCyc:DIHYDROPICRED-MONOMER http://biocyc.org/getid?id=EcoCyc:DIHYDROPICRED-MONOMER BioCyc MetaCyc:DIHYDROPICRED-MONOMER http://biocyc.org/getid?id=MetaCyc:DIHYDROPICRED-MONOMER COG COG0289 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0289 DIP DIP-9399N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9399N DOI 10.1021/bi00011a002 http://dx.doi.org/10.1021/bi00011a002 DOI 10.1021/bi00011a003 http://dx.doi.org/10.1021/bi00011a003 DOI 10.1021/bi9615809 http://dx.doi.org/10.1021/bi9615809 DOI 10.1021/bi9719915 http://dx.doi.org/10.1021/bi9719915 DOI 10.1021/jm100349s http://dx.doi.org/10.1021/jm100349s DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.81.13.4139 http://dx.doi.org/10.1073/pnas.81.13.4139 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01782-07 http://dx.doi.org/10.1128/JB.01782-07 EC_number EC:1.17.1.8 {ECO:0000255|HAMAP-Rule:MF_00102} http://www.genome.jp/dbget-bin/www_bget?EC:1.17.1.8 {ECO:0000255|HAMAP-Rule:MF_00102} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01597 http://www.ebi.ac.uk/ena/data/view/J01597 EMBL M10611 http://www.ebi.ac.uk/ena/data/view/M10611 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.17.1.8 {ECO:0000255|HAMAP-Rule:MF_00102} http://enzyme.expasy.org/EC/1.17.1.8 {ECO:0000255|HAMAP-Rule:MF_00102} EchoBASE EB0202 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0202 EcoGene EG10206 http://www.ecogene.org/geneInfo.php?eg_id=EG10206 EnsemblBacteria AAC73142 http://www.ensemblgenomes.org/id/AAC73142 EnsemblBacteria AAC73142 http://www.ensemblgenomes.org/id/AAC73142 EnsemblBacteria BAB96600 http://www.ensemblgenomes.org/id/BAB96600 EnsemblBacteria BAB96600 http://www.ensemblgenomes.org/id/BAB96600 EnsemblBacteria BAB96600 http://www.ensemblgenomes.org/id/BAB96600 EnsemblBacteria b0031 http://www.ensemblgenomes.org/id/b0031 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008839 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008839 GO_function GO:0016726 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016726 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0050661 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050661 GO_function GO:0051287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051287 GO_process GO:0008652 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008652 GO_process GO:0009089 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009089 GO_process GO:0019877 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019877 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 944762 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944762 HAMAP MF_00102 http://hamap.expasy.org/unirule/MF_00102 HOGENOM HOG000227153 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000227153&db=HOGENOM6 InParanoid P04036 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P04036 IntAct P04036 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P04036* IntEnz 1.17.1.8 {ECO:0000255|HAMAP-Rule:MF_00102} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.17.1.8 {ECO:0000255|HAMAP-Rule:MF_00102} InterPro IPR000846 http://www.ebi.ac.uk/interpro/entry/IPR000846 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR022663 http://www.ebi.ac.uk/interpro/entry/IPR022663 InterPro IPR022664 http://www.ebi.ac.uk/interpro/entry/IPR022664 InterPro IPR023940 http://www.ebi.ac.uk/interpro/entry/IPR023940 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0029 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0029 KEGG_Gene eco:b0031 http://www.genome.jp/dbget-bin/www_bget?eco:b0031 KEGG_Orthology KO:K00215 http://www.genome.jp/dbget-bin/www_bget?KO:K00215 KEGG_Pathway ko00300 http://www.genome.jp/kegg-bin/show_pathway?ko00300 KEGG_Reaction rn:R04198 http://www.genome.jp/dbget-bin/www_bget?rn:R04198 KEGG_Reaction rn:R04199 http://www.genome.jp/dbget-bin/www_bget?rn:R04199 OMA YAREGHT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YAREGHT PANTHER PTHR20836 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20836 PDB 1ARZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1ARZ PDB 1DIH http://www.ebi.ac.uk/pdbe-srv/view/entry/1DIH PDB 1DRU http://www.ebi.ac.uk/pdbe-srv/view/entry/1DRU PDB 1DRV http://www.ebi.ac.uk/pdbe-srv/view/entry/1DRV PDB 1DRW http://www.ebi.ac.uk/pdbe-srv/view/entry/1DRW PDBsum 1ARZ http://www.ebi.ac.uk/pdbsum/1ARZ PDBsum 1DIH http://www.ebi.ac.uk/pdbsum/1DIH PDBsum 1DRU http://www.ebi.ac.uk/pdbsum/1DRU PDBsum 1DRV http://www.ebi.ac.uk/pdbsum/1DRV PDBsum 1DRW http://www.ebi.ac.uk/pdbsum/1DRW PROSITE PS01298 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01298 PSORT swissprot:DAPB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DAPB_ECOLI PSORT-B swissprot:DAPB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DAPB_ECOLI PSORT2 swissprot:DAPB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DAPB_ECOLI Pfam PF01113 http://pfam.xfam.org/family/PF01113 Pfam PF05173 http://pfam.xfam.org/family/PF05173 Phobius swissprot:DAPB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DAPB_ECOLI PhylomeDB P04036 http://phylomedb.org/?seqid=P04036 ProteinModelPortal P04036 http://www.proteinmodelportal.org/query/uniprot/P04036 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18502871 http://www.ncbi.nlm.nih.gov/pubmed/18502871 PubMed 20503968 http://www.ncbi.nlm.nih.gov/pubmed/20503968 PubMed 6094578 http://www.ncbi.nlm.nih.gov/pubmed/6094578 PubMed 6377309 http://www.ncbi.nlm.nih.gov/pubmed/6377309 PubMed 7893644 http://www.ncbi.nlm.nih.gov/pubmed/7893644 PubMed 7893645 http://www.ncbi.nlm.nih.gov/pubmed/7893645 PubMed 8873595 http://www.ncbi.nlm.nih.gov/pubmed/8873595 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9398235 http://www.ncbi.nlm.nih.gov/pubmed/9398235 RefSeq NP_414572 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414572 RefSeq WP_000543604 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000543604 SMR P04036 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P04036 STRING 511145.b0031 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0031&targetmode=cogs STRING COG0289 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0289&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 SWISS-2DPAGE P04036 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P04036 TIGRFAMs TIGR00036 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00036 UniProtKB DAPB_ECOLI http://www.uniprot.org/uniprot/DAPB_ECOLI UniProtKB-AC P04036 http://www.uniprot.org/uniprot/P04036 charge swissprot:DAPB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DAPB_ECOLI eggNOG COG0289 http://eggnogapi.embl.de/nog_data/html/tree/COG0289 eggNOG ENOG4105DUK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DUK epestfind swissprot:DAPB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DAPB_ECOLI garnier swissprot:DAPB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DAPB_ECOLI helixturnhelix swissprot:DAPB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DAPB_ECOLI hmoment swissprot:DAPB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DAPB_ECOLI iep swissprot:DAPB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DAPB_ECOLI inforesidue swissprot:DAPB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DAPB_ECOLI octanol swissprot:DAPB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DAPB_ECOLI pepcoil swissprot:DAPB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DAPB_ECOLI pepdigest swissprot:DAPB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DAPB_ECOLI pepinfo swissprot:DAPB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DAPB_ECOLI pepnet swissprot:DAPB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DAPB_ECOLI pepstats swissprot:DAPB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DAPB_ECOLI pepwheel swissprot:DAPB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DAPB_ECOLI pepwindow swissprot:DAPB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DAPB_ECOLI sigcleave swissprot:DAPB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DAPB_ECOLI ## Database ID URL or Descriptions # AltName INTA_ECOLI Prophage CP4-57 integrase # BioGrid 4260622 13 # EcoGene EG11783 intA # FUNCTION INTA_ECOLI Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome. # GO_component GO:0019038 provirus; ISS:EcoCyc. # GO_function GO:0008979 prophage integrase activity; IMP:EcoCyc. # GO_function GO:0043565 sequence-specific DNA binding; IBA:GO_Central. # GO_process GO:0006310 DNA recombination; IEA:UniProtKB-KW. # GO_process GO:0032359 provirus excision; IMP:EcoCyc. # GO_process GO:0046718 viral entry into host cell; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0044403 symbiosis, encompassing mutualism through parasitism # Gene3D 1.10.150.130 -; 1. # Gene3D 1.10.443.10 -; 1. # INTERACTION INTA_ECOLI P06959 aceF; NbExp=2; IntAct=EBI-552967, EBI-542707; # IntAct P32053 26 # InterPro IPR002104 Integrase_catalytic # InterPro IPR011010 DNA_brk_join_enz # InterPro IPR013762 Integrase-like_cat # InterPro IPR023109 Integrase_recombinase_N # InterPro IPR025166 DUF4102 # Organism INTA_ECOLI Escherichia coli (strain K12) # PATRIC 32120641 VBIEscCol129921_2719 # PIR H65040 H65040 # Pfam PF00589 Phage_integrase # Pfam PF13356 DUF4102 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Prophage integrase IntA {ECO 0000305} # RefSeq NP_417111 NC_000913.3 # RefSeq WP_000101723 NZ_LN832404.1 # SIMILARITY Belongs to the 'phage' integrase family. {ECO 0000305}. # SUPFAM SSF56349 SSF56349 # eggNOG COG0582 LUCA # eggNOG ENOG4105DFP Bacteria BLAST swissprot:INTA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INTA_ECOLI BioCyc ECOL316407:JW2602-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2602-MONOMER BioCyc EcoCyc:EG11783-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11783-MONOMER DIP DIP-10034N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10034N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.91.20.9223 http://dx.doi.org/10.1073/pnas.91.20.9223 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D12501 http://www.ebi.ac.uk/ena/data/view/D12501 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U03737 http://www.ebi.ac.uk/ena/data/view/U03737 EMBL U36840 http://www.ebi.ac.uk/ena/data/view/U36840 EchoBASE EB1731 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1731 EcoGene EG11783 http://www.ecogene.org/geneInfo.php?eg_id=EG11783 EnsemblBacteria AAC75670 http://www.ensemblgenomes.org/id/AAC75670 EnsemblBacteria AAC75670 http://www.ensemblgenomes.org/id/AAC75670 EnsemblBacteria BAA20921 http://www.ensemblgenomes.org/id/BAA20921 EnsemblBacteria BAA20921 http://www.ensemblgenomes.org/id/BAA20921 EnsemblBacteria BAA20921 http://www.ensemblgenomes.org/id/BAA20921 EnsemblBacteria b2622 http://www.ensemblgenomes.org/id/b2622 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0019038 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019038 GO_function GO:0008979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008979 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0032359 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032359 GO_process GO:0046718 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046718 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0044403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403 Gene3D 1.10.150.130 http://www.cathdb.info/version/latest/superfamily/1.10.150.130 Gene3D 1.10.443.10 http://www.cathdb.info/version/latest/superfamily/1.10.443.10 GeneID 946160 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946160 HOGENOM HOG000263105 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000263105&db=HOGENOM6 InParanoid P32053 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32053 IntAct P32053 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32053* InterPro IPR002104 http://www.ebi.ac.uk/interpro/entry/IPR002104 InterPro IPR011010 http://www.ebi.ac.uk/interpro/entry/IPR011010 InterPro IPR013762 http://www.ebi.ac.uk/interpro/entry/IPR013762 InterPro IPR023109 http://www.ebi.ac.uk/interpro/entry/IPR023109 InterPro IPR025166 http://www.ebi.ac.uk/interpro/entry/IPR025166 KEGG_Gene ecj:JW2602 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2602 KEGG_Gene eco:b2622 http://www.genome.jp/dbget-bin/www_bget?eco:b2622 MINT MINT-1219095 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1219095 OMA NEQGFES http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NEQGFES PSORT swissprot:INTA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INTA_ECOLI PSORT-B swissprot:INTA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INTA_ECOLI PSORT2 swissprot:INTA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INTA_ECOLI Pfam PF00589 http://pfam.xfam.org/family/PF00589 Pfam PF13356 http://pfam.xfam.org/family/PF13356 Phobius swissprot:INTA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INTA_ECOLI PhylomeDB P32053 http://phylomedb.org/?seqid=P32053 ProteinModelPortal P32053 http://www.proteinmodelportal.org/query/uniprot/P32053 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7511583 http://www.ncbi.nlm.nih.gov/pubmed/7511583 PubMed 7524073 http://www.ncbi.nlm.nih.gov/pubmed/7524073 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417111 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417111 RefSeq WP_000101723 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000101723 SMR P32053 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32053 STRING 511145.b2622 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2622&targetmode=cogs SUPFAM SSF56349 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56349 UniProtKB INTA_ECOLI http://www.uniprot.org/uniprot/INTA_ECOLI UniProtKB-AC P32053 http://www.uniprot.org/uniprot/P32053 charge swissprot:INTA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INTA_ECOLI eggNOG COG0582 http://eggnogapi.embl.de/nog_data/html/tree/COG0582 eggNOG ENOG4105DFP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DFP epestfind swissprot:INTA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INTA_ECOLI garnier swissprot:INTA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INTA_ECOLI helixturnhelix swissprot:INTA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INTA_ECOLI hmoment swissprot:INTA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INTA_ECOLI iep swissprot:INTA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INTA_ECOLI inforesidue swissprot:INTA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INTA_ECOLI octanol swissprot:INTA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INTA_ECOLI pepcoil swissprot:INTA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INTA_ECOLI pepdigest swissprot:INTA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INTA_ECOLI pepinfo swissprot:INTA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INTA_ECOLI pepnet swissprot:INTA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INTA_ECOLI pepstats swissprot:INTA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INTA_ECOLI pepwheel swissprot:INTA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INTA_ECOLI pepwindow swissprot:INTA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INTA_ECOLI sigcleave swissprot:INTA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INTA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262368 16 # COFACTOR Name=FAD; Xref=ChEBI:CHEBI 57692; Evidence={ECO:0000305}; # EcoGene EG12997 glcD # GO_component GO:0009339 glycolate oxidase complex; IEA:InterPro. # GO_function GO:0008891 glycolate oxidase activity; IEA:InterPro. # GO_function GO:0019154 glycolate dehydrogenase activity; IMP:EcoCyc. # GO_function GO:0050660 flavin adenine dinucleotide binding; IEA:InterPro. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0046296 glycolate catabolic process; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.45.10 -; 1. # Gene3D 3.30.43.10 -; 1. # Gene3D 3.30.465.10 -; 1. # IntAct P0AEP9 3 # InterPro IPR004113 FAD-linked_oxidase_C # InterPro IPR004490 GlcD # InterPro IPR006094 Oxid_FAD_bind_N # InterPro IPR016164 FAD-linked_Oxase-like_C # InterPro IPR016166 FAD-bd_2 # InterPro IPR016167 FAD-bd_2_sub1 # InterPro IPR016169 CO_DH_flavot_FAD-bd_sub2 # InterPro IPR016171 Vanillyl_alc_oxidase_C-sub2 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00630 Glyoxylate and dicarboxylate metabolism # Organism GLCD_ECOLI Escherichia coli (strain K12) # PATRIC 32121374 VBIEscCol129921_3074 # PIR A65084 A65084 # PROSITE PS51387 FAD_PCMH # Pfam PF01565 FAD_binding_4 # Pfam PF02913 FAD-oxidase_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLCD_ECOLI Glycolate oxidase subunit GlcD # RefSeq NP_417453 NC_000913.3 # RefSeq WP_000026117 NZ_LN832404.1 # SIMILARITY Belongs to the FAD-binding oxidoreductase/transferase type 4 family. {ECO 0000305}. # SIMILARITY Contains 1 FAD-binding PCMH-type domain. {ECO:0000255|PROSITE-ProRule PRU00718}. # SUPFAM SSF55103 SSF55103 # SUPFAM SSF56176 SSF56176 # TIGRFAMs TIGR00387 glcD # eggNOG COG0277 LUCA # eggNOG ENOG4105CQB Bacteria BLAST swissprot:GLCD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLCD_ECOLI BioCyc ECOL316407:JW2946-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2946-MONOMER BioCyc EcoCyc:G7545-MONOMER http://biocyc.org/getid?id=EcoCyc:G7545-MONOMER BioCyc MetaCyc:G7545-MONOMER http://biocyc.org/getid?id=MetaCyc:G7545-MONOMER COG COG0277 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0277 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L43490 http://www.ebi.ac.uk/ena/data/view/L43490 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2820 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2820 EcoGene EG12997 http://www.ecogene.org/geneInfo.php?eg_id=EG12997 EnsemblBacteria AAC76015 http://www.ensemblgenomes.org/id/AAC76015 EnsemblBacteria AAC76015 http://www.ensemblgenomes.org/id/AAC76015 EnsemblBacteria BAE77040 http://www.ensemblgenomes.org/id/BAE77040 EnsemblBacteria BAE77040 http://www.ensemblgenomes.org/id/BAE77040 EnsemblBacteria BAE77040 http://www.ensemblgenomes.org/id/BAE77040 EnsemblBacteria b2979 http://www.ensemblgenomes.org/id/b2979 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009339 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009339 GO_function GO:0008891 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008891 GO_function GO:0019154 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019154 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0046296 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046296 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.45.10 http://www.cathdb.info/version/latest/superfamily/1.10.45.10 Gene3D 3.30.43.10 http://www.cathdb.info/version/latest/superfamily/3.30.43.10 Gene3D 3.30.465.10 http://www.cathdb.info/version/latest/superfamily/3.30.465.10 GeneID 947353 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947353 HOGENOM HOG000230998 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230998&db=HOGENOM6 InParanoid P0AEP9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEP9 IntAct P0AEP9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEP9* InterPro IPR004113 http://www.ebi.ac.uk/interpro/entry/IPR004113 InterPro IPR004490 http://www.ebi.ac.uk/interpro/entry/IPR004490 InterPro IPR006094 http://www.ebi.ac.uk/interpro/entry/IPR006094 InterPro IPR016164 http://www.ebi.ac.uk/interpro/entry/IPR016164 InterPro IPR016166 http://www.ebi.ac.uk/interpro/entry/IPR016166 InterPro IPR016167 http://www.ebi.ac.uk/interpro/entry/IPR016167 InterPro IPR016169 http://www.ebi.ac.uk/interpro/entry/IPR016169 InterPro IPR016171 http://www.ebi.ac.uk/interpro/entry/IPR016171 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2946 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2946 KEGG_Gene eco:b2979 http://www.genome.jp/dbget-bin/www_bget?eco:b2979 KEGG_Orthology KO:K00104 http://www.genome.jp/dbget-bin/www_bget?KO:K00104 KEGG_Pathway ko00630 http://www.genome.jp/kegg-bin/show_pathway?ko00630 KEGG_Reaction rn:R00475 http://www.genome.jp/dbget-bin/www_bget?rn:R00475 OMA TPRTCGE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TPRTCGE PROSITE PS51387 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51387 PSORT swissprot:GLCD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLCD_ECOLI PSORT-B swissprot:GLCD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLCD_ECOLI PSORT2 swissprot:GLCD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLCD_ECOLI Pfam PF01565 http://pfam.xfam.org/family/PF01565 Pfam PF02913 http://pfam.xfam.org/family/PF02913 Phobius swissprot:GLCD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLCD_ECOLI PhylomeDB P0AEP9 http://phylomedb.org/?seqid=P0AEP9 ProteinModelPortal P0AEP9 http://www.proteinmodelportal.org/query/uniprot/P0AEP9 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8606183 http://www.ncbi.nlm.nih.gov/pubmed/8606183 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417453 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417453 RefSeq WP_000026117 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000026117 STRING 511145.b2979 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2979&targetmode=cogs STRING COG0277 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0277&targetmode=cogs SUPFAM SSF55103 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55103 SUPFAM SSF56176 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56176 TIGRFAMs TIGR00387 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00387 UniProtKB GLCD_ECOLI http://www.uniprot.org/uniprot/GLCD_ECOLI UniProtKB-AC P0AEP9 http://www.uniprot.org/uniprot/P0AEP9 charge swissprot:GLCD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLCD_ECOLI eggNOG COG0277 http://eggnogapi.embl.de/nog_data/html/tree/COG0277 eggNOG ENOG4105CQB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CQB epestfind swissprot:GLCD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLCD_ECOLI garnier swissprot:GLCD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLCD_ECOLI helixturnhelix swissprot:GLCD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLCD_ECOLI hmoment swissprot:GLCD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLCD_ECOLI iep swissprot:GLCD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLCD_ECOLI inforesidue swissprot:GLCD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLCD_ECOLI octanol swissprot:GLCD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLCD_ECOLI pepcoil swissprot:GLCD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLCD_ECOLI pepdigest swissprot:GLCD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLCD_ECOLI pepinfo swissprot:GLCD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLCD_ECOLI pepnet swissprot:GLCD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLCD_ECOLI pepstats swissprot:GLCD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLCD_ECOLI pepwheel swissprot:GLCD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLCD_ECOLI pepwindow swissprot:GLCD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLCD_ECOLI sigcleave swissprot:GLCD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLCD_ECOLI ## Database ID URL or Descriptions # AltName RCSA_ECOLI Colanic acid capsular biosynthesis activation protein A # BioGrid 4261047 8 # CDD cd06170 LuxR_C_like # EcoGene EG10820 rcsA # FUNCTION RCSA_ECOLI Component of the Rcs signaling system, which controls transcription of numerous genes. Binds, with RcsB, to the RcsAB box to regulate expression of genes involved in colanic acid capsule synthesis. {ECO 0000255|HAMAP-Rule MF_00982, ECO 0000269|PubMed 10702265, ECO 0000269|PubMed 1999391}. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0004871 signal transducer activity; IEA:UniProtKB-HAMAP. # GO_process GO:0006351 transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-HAMAP. # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004871 signal transducer activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # HAMAP MF_00982 RcsA # INDUCTION RCSA_ECOLI Autoregulated. Repressed by H-NS. Induced by the DsrA small regulatory RNA, which inhibits the H-NS mediated transcriptional silencing. {ECO 0000269|PubMed 10702265, ECO 0000269|PubMed 7534408}. # IntAct P0DMC9 29 # InterPro IPR000792 Tscrpt_reg_LuxR_C # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR016032 Sig_transdc_resp-reg_C-effctor # InterPro IPR030866 RcsA # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko03000 Transcription factors # KEGG_Pathway ko02020 Two-component system # Organism RCSA_ECOLI Escherichia coli (strain K12) # PIR A37320 A37320 # PRINTS PR00038 HTHLUXR # PROSITE PS00622 HTH_LUXR_1 # PROSITE PS50043 HTH_LUXR_2 # PTM RCSA_ECOLI Degraded by the Lon and the HslUV proteases (PubMed 1999391 and PubMed 14766922). Interaction with RcsB protects RcsA from degradation (PubMed 1999391). {ECO 0000269|PubMed 1999391}. # Pfam PF00196 GerE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Transcriptional regulatory protein RcsA {ECO:0000255|HAMAP-Rule MF_00982} # RefSeq NP_416461 NC_000913.3 # RefSeq WP_000104001 NZ_LN832404.1 # SIMILARITY Belongs to the RcsA family. {ECO:0000255|HAMAP- Rule MF_00982}. # SIMILARITY Contains 1 HTH luxR-type DNA-binding domain. {ECO:0000255|HAMAP-Rule MF_00982}. # SMART SM00421 HTH_LUXR # SUBUNIT RCSA_ECOLI Interacts with RcsB. {ECO 0000255|HAMAP-Rule MF_00982, ECO 0000269|PubMed 10702265}. # SUPFAM SSF46894 SSF46894 # eggNOG COG2771 LUCA # eggNOG ENOG4107TKS Bacteria BLAST swissprot:RCSA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RCSA_ECOLI BioCyc EcoCyc:PD02233 http://biocyc.org/getid?id=EcoCyc:PD02233 COG COG2771 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2771 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.92.6.2003 http://dx.doi.org/10.1073/pnas.92.6.2003 DOI 10.1074/jbc.275.10.7013 http://dx.doi.org/10.1074/jbc.275.10.7013 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1099/mic.0.26446-0 http://dx.doi.org/10.1099/mic.0.26446-0 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M58003 http://www.ebi.ac.uk/ena/data/view/M58003 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U17137 http://www.ebi.ac.uk/ena/data/view/U17137 EchoBASE EB0813 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0813 EcoGene EG10820 http://www.ecogene.org/geneInfo.php?eg_id=EG10820 EnsemblBacteria AAC75018 http://www.ensemblgenomes.org/id/AAC75018 EnsemblBacteria AAC75018 http://www.ensemblgenomes.org/id/AAC75018 EnsemblBacteria BAA15776 http://www.ensemblgenomes.org/id/BAA15776 EnsemblBacteria BAA15776 http://www.ensemblgenomes.org/id/BAA15776 EnsemblBacteria BAA15776 http://www.ensemblgenomes.org/id/BAA15776 EnsemblBacteria b1951 http://www.ensemblgenomes.org/id/b1951 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 946467 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946467 HAMAP MF_00982 http://hamap.expasy.org/unirule/MF_00982 IntAct P0DMC9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0DMC9* InterPro IPR000792 http://www.ebi.ac.uk/interpro/entry/IPR000792 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR016032 http://www.ebi.ac.uk/interpro/entry/IPR016032 InterPro IPR030866 http://www.ebi.ac.uk/interpro/entry/IPR030866 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW1935 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1935 KEGG_Gene eco:b1951 http://www.genome.jp/dbget-bin/www_bget?eco:b1951 KEGG_Orthology KO:K07781 http://www.genome.jp/dbget-bin/www_bget?KO:K07781 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA PGVVFIN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PGVVFIN PRINTS PR00038 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00038 PROSITE PS00622 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00622 PROSITE PS50043 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50043 PSORT swissprot:RCSA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RCSA_ECOLI PSORT-B swissprot:RCSA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RCSA_ECOLI PSORT2 swissprot:RCSA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RCSA_ECOLI Pfam PF00196 http://pfam.xfam.org/family/PF00196 Phobius swissprot:RCSA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RCSA_ECOLI ProteinModelPortal P0DMC9 http://www.proteinmodelportal.org/query/uniprot/P0DMC9 PubMed 10702265 http://www.ncbi.nlm.nih.gov/pubmed/10702265 PubMed 14766922 http://www.ncbi.nlm.nih.gov/pubmed/14766922 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1999391 http://www.ncbi.nlm.nih.gov/pubmed/1999391 PubMed 7534408 http://www.ncbi.nlm.nih.gov/pubmed/7534408 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416461 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416461 RefSeq WP_000104001 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000104001 SMART SM00421 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00421 SMR P0DMC9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0DMC9 STRING 511145.b1951 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1951&targetmode=cogs STRING COG2771 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2771&targetmode=cogs SUPFAM SSF46894 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46894 UniProtKB RCSA_ECOLI http://www.uniprot.org/uniprot/RCSA_ECOLI UniProtKB-AC P0DMC9 http://www.uniprot.org/uniprot/P0DMC9 charge swissprot:RCSA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RCSA_ECOLI eggNOG COG2771 http://eggnogapi.embl.de/nog_data/html/tree/COG2771 eggNOG ENOG4107TKS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107TKS epestfind swissprot:RCSA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RCSA_ECOLI garnier swissprot:RCSA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RCSA_ECOLI helixturnhelix swissprot:RCSA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RCSA_ECOLI hmoment swissprot:RCSA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RCSA_ECOLI iep swissprot:RCSA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RCSA_ECOLI inforesidue swissprot:RCSA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RCSA_ECOLI octanol swissprot:RCSA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RCSA_ECOLI pepcoil swissprot:RCSA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RCSA_ECOLI pepdigest swissprot:RCSA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RCSA_ECOLI pepinfo swissprot:RCSA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RCSA_ECOLI pepnet swissprot:RCSA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RCSA_ECOLI pepstats swissprot:RCSA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RCSA_ECOLI pepwheel swissprot:RCSA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RCSA_ECOLI pepwindow swissprot:RCSA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RCSA_ECOLI sigcleave swissprot:RCSA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RCSA_ECOLI ## Database ID URL or Descriptions # BioGrid 4263095 12 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG14282 ykiA # InterPro IPR024497 DUF2773 # Organism YKIA_ECOLI Escherichia coli (strain K12) # PATRIC 48659988 VBIEscCol107702_0388 # PIR H64767 H64767 # Pfam PF10971 DUF2773 # ProDom PD029376 PD029376 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YKIA_ECOLI Putative uncharacterized protein YkiA # RefSeq WP_000941997 NZ_LN832404.1 # SIMILARITY To E.coli YdbD C-terminal region. {ECO 0000305}. BLAST swissprot:YKIA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YKIA_ECOLI BioCyc ECOL316407:JW0383-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0383-MONOMER BioCyc EcoCyc:G6231-MONOMER http://biocyc.org/getid?id=EcoCyc:G6231-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4030 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4030 EcoGene EG14282 http://www.ecogene.org/geneInfo.php?eg_id=EG14282 EnsemblBacteria BAE76173 http://www.ensemblgenomes.org/id/BAE76173 EnsemblBacteria BAE76173 http://www.ensemblgenomes.org/id/BAE76173 EnsemblBacteria BAE76173 http://www.ensemblgenomes.org/id/BAE76173 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv HOGENOM HOG000009351 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009351&db=HOGENOM6 InterPro IPR024497 http://www.ebi.ac.uk/interpro/entry/IPR024497 KEGG_Gene ecj:JW0383 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0383 OMA RNAHTPV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RNAHTPV PSORT swissprot:YKIA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YKIA_ECOLI PSORT-B swissprot:YKIA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YKIA_ECOLI PSORT2 swissprot:YKIA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YKIA_ECOLI Pfam PF10971 http://pfam.xfam.org/family/PF10971 Phobius swissprot:YKIA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YKIA_ECOLI ProteinModelPortal P75704 http://www.proteinmodelportal.org/query/uniprot/P75704 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000941997 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000941997 UniProtKB YKIA_ECOLI http://www.uniprot.org/uniprot/YKIA_ECOLI UniProtKB-AC P75704 http://www.uniprot.org/uniprot/P75704 charge swissprot:YKIA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YKIA_ECOLI epestfind swissprot:YKIA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YKIA_ECOLI garnier swissprot:YKIA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YKIA_ECOLI helixturnhelix swissprot:YKIA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YKIA_ECOLI hmoment swissprot:YKIA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YKIA_ECOLI iep swissprot:YKIA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YKIA_ECOLI inforesidue swissprot:YKIA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YKIA_ECOLI octanol swissprot:YKIA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YKIA_ECOLI pepcoil swissprot:YKIA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YKIA_ECOLI pepdigest swissprot:YKIA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YKIA_ECOLI pepinfo swissprot:YKIA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YKIA_ECOLI pepnet swissprot:YKIA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YKIA_ECOLI pepstats swissprot:YKIA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YKIA_ECOLI pepwheel swissprot:YKIA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YKIA_ECOLI pepwindow swissprot:YKIA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YKIA_ECOLI sigcleave swissprot:YKIA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YKIA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259817 9 # EcoGene EG12159 yaiE # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # Gene3D 2.60.120.10 -; 1. # HAMAP MF_01537 UPF0345 # IntAct P0C037 9 # InterPro IPR009664 DUF1255 # InterPro IPR011051 RmlC_Cupin # InterPro IPR014710 RmlC-like_jellyroll # Organism YAIE_ECOLI Escherichia coli (strain K12) # PATRIC 32115923 VBIEscCol129921_0403 # PIR G64767 G64767 # Pfam PF06865 DUF1255 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UPF0345 protein YaiE {ECO:0000255|HAMAP-Rule MF_01537} # RefSeq NP_414925 NC_000913.3 # RefSeq WP_000941942 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0345 family. {ECO:0000255|HAMAP- Rule MF_01537}. # SUPFAM SSF51182 SSF51182 # eggNOG COG3123 LUCA # eggNOG ENOG4105NBK Bacteria BLAST swissprot:YAIE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAIE_ECOLI BioCyc ECOL316407:JW0382-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0382-MONOMER BioCyc EcoCyc:EG12159-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12159-MONOMER COG COG3123 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3123 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EMBL X76979 http://www.ebi.ac.uk/ena/data/view/X76979 EchoBASE EB2079 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2079 EcoGene EG12159 http://www.ecogene.org/geneInfo.php?eg_id=EG12159 EnsemblBacteria AAC73494 http://www.ensemblgenomes.org/id/AAC73494 EnsemblBacteria AAC73494 http://www.ensemblgenomes.org/id/AAC73494 EnsemblBacteria BAE76172 http://www.ensemblgenomes.org/id/BAE76172 EnsemblBacteria BAE76172 http://www.ensemblgenomes.org/id/BAE76172 EnsemblBacteria BAE76172 http://www.ensemblgenomes.org/id/BAE76172 EnsemblBacteria b0391 http://www.ensemblgenomes.org/id/b0391 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 Gene3D 2.60.120.10 http://www.cathdb.info/version/latest/superfamily/2.60.120.10 GeneID 945048 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945048 HAMAP MF_01537 http://hamap.expasy.org/unirule/MF_01537 HOGENOM HOG000218057 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218057&db=HOGENOM6 InParanoid P0C037 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0C037 IntAct P0C037 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0C037* InterPro IPR009664 http://www.ebi.ac.uk/interpro/entry/IPR009664 InterPro IPR011051 http://www.ebi.ac.uk/interpro/entry/IPR011051 InterPro IPR014710 http://www.ebi.ac.uk/interpro/entry/IPR014710 KEGG_Gene ecj:JW0382 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0382 KEGG_Gene eco:b0391 http://www.genome.jp/dbget-bin/www_bget?eco:b0391 KEGG_Orthology KO:K09913 http://www.genome.jp/dbget-bin/www_bget?KO:K09913 OMA YHYICHF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YHYICHF PSORT swissprot:YAIE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAIE_ECOLI PSORT-B swissprot:YAIE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAIE_ECOLI PSORT2 swissprot:YAIE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAIE_ECOLI Pfam PF06865 http://pfam.xfam.org/family/PF06865 Phobius swissprot:YAIE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAIE_ECOLI PhylomeDB P0C037 http://phylomedb.org/?seqid=P0C037 ProteinModelPortal P0C037 http://www.proteinmodelportal.org/query/uniprot/P0C037 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8807285 http://www.ncbi.nlm.nih.gov/pubmed/8807285 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414925 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414925 RefSeq WP_000941942 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000941942 SMR P0C037 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0C037 STRING 511145.b0391 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0391&targetmode=cogs STRING COG3123 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3123&targetmode=cogs SUPFAM SSF51182 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51182 UniProtKB YAIE_ECOLI http://www.uniprot.org/uniprot/YAIE_ECOLI UniProtKB-AC P0C037 http://www.uniprot.org/uniprot/P0C037 charge swissprot:YAIE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAIE_ECOLI eggNOG COG3123 http://eggnogapi.embl.de/nog_data/html/tree/COG3123 eggNOG ENOG4105NBK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105NBK epestfind swissprot:YAIE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAIE_ECOLI garnier swissprot:YAIE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAIE_ECOLI helixturnhelix swissprot:YAIE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAIE_ECOLI hmoment swissprot:YAIE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAIE_ECOLI iep swissprot:YAIE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAIE_ECOLI inforesidue swissprot:YAIE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAIE_ECOLI octanol swissprot:YAIE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAIE_ECOLI pepcoil swissprot:YAIE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAIE_ECOLI pepdigest swissprot:YAIE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAIE_ECOLI pepinfo swissprot:YAIE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAIE_ECOLI pepnet swissprot:YAIE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAIE_ECOLI pepstats swissprot:YAIE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAIE_ECOLI pepwheel swissprot:YAIE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAIE_ECOLI pepwindow swissprot:YAIE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAIE_ECOLI sigcleave swissprot:YAIE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAIE_ECOLI ## Database ID URL or Descriptions # BioGrid 4261211 154 # CDD cd06174 MFS # EcoGene EG12141 ydhC # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005215 transporter activity; IEA:InterPro. # GO_process GO:0055085 transmembrane transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0055085 transmembrane transport # InterPro IPR004812 Efflux_drug-R_Bcr/CmlA # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # Organism YDHC_ECOLI Escherichia coli (strain K12) # PATRIC 32118626 VBIEscCol129921_1733 # PIR F64923 F64923 # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDHC_ECOLI Inner membrane transport protein YdhC # RefSeq WP_001182347 NZ_LN832404.1 # RefSeq YP_025306 NC_000913.3 # SEQUENCE CAUTION Sequence=X69109; Type=Frameshift; Positions=Several; Evidence={ECO 0000305}; # SIMILARITY Belongs to the major facilitator superfamily. Bcr/CmlA family. {ECO 0000305}. # SUBCELLULAR LOCATION YDHC_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.2.62 the major facilitator superfamily (mfs) # TIGRFAMs TIGR00710 efflux_Bcr_CflA # eggNOG ENOG4105CZQ Bacteria # eggNOG ENOG410XPCY LUCA BLAST swissprot:YDHC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDHC_ECOLI BioCyc ECOL316407:JW1652-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1652-MONOMER BioCyc EcoCyc:YDHC-MONOMER http://biocyc.org/getid?id=EcoCyc:YDHC-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X69109 http://www.ebi.ac.uk/ena/data/view/X69109 EchoBASE EB2062 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2062 EcoGene EG12141 http://www.ecogene.org/geneInfo.php?eg_id=EG12141 EnsemblBacteria AAT48135 http://www.ensemblgenomes.org/id/AAT48135 EnsemblBacteria AAT48135 http://www.ensemblgenomes.org/id/AAT48135 EnsemblBacteria BAA15426 http://www.ensemblgenomes.org/id/BAA15426 EnsemblBacteria BAA15426 http://www.ensemblgenomes.org/id/BAA15426 EnsemblBacteria BAA15426 http://www.ensemblgenomes.org/id/BAA15426 EnsemblBacteria b1660 http://www.ensemblgenomes.org/id/b1660 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 946077 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946077 HOGENOM HOG000143172 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000143172&db=HOGENOM6 InParanoid P37597 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37597 InterPro IPR004812 http://www.ebi.ac.uk/interpro/entry/IPR004812 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Gene ecj:JW1652 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1652 KEGG_Gene eco:b1660 http://www.genome.jp/dbget-bin/www_bget?eco:b1660 OMA FKIAIAR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FKIAIAR PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:YDHC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDHC_ECOLI PSORT-B swissprot:YDHC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDHC_ECOLI PSORT2 swissprot:YDHC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDHC_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:YDHC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDHC_ECOLI PhylomeDB P37597 http://phylomedb.org/?seqid=P37597 ProteinModelPortal P37597 http://www.proteinmodelportal.org/query/uniprot/P37597 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001182347 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001182347 RefSeq YP_025306 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_025306 STRING 511145.b1660 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1660&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.2.62 http://www.tcdb.org/search/result.php?tc=2.A.1.2.62 TIGRFAMs TIGR00710 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00710 UniProtKB YDHC_ECOLI http://www.uniprot.org/uniprot/YDHC_ECOLI UniProtKB-AC P37597 http://www.uniprot.org/uniprot/P37597 charge swissprot:YDHC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDHC_ECOLI eggNOG ENOG4105CZQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CZQ eggNOG ENOG410XPCY http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPCY epestfind swissprot:YDHC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDHC_ECOLI garnier swissprot:YDHC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDHC_ECOLI helixturnhelix swissprot:YDHC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDHC_ECOLI hmoment swissprot:YDHC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDHC_ECOLI iep swissprot:YDHC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDHC_ECOLI inforesidue swissprot:YDHC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDHC_ECOLI octanol swissprot:YDHC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDHC_ECOLI pepcoil swissprot:YDHC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDHC_ECOLI pepdigest swissprot:YDHC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDHC_ECOLI pepinfo swissprot:YDHC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDHC_ECOLI pepnet swissprot:YDHC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDHC_ECOLI pepstats swissprot:YDHC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDHC_ECOLI pepwheel swissprot:YDHC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDHC_ECOLI pepwindow swissprot:YDHC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDHC_ECOLI sigcleave swissprot:YDHC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDHC_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES pH dependence: Optimum pH is 7.0. {ECO 0000269|PubMed:15294295}; # BRENDA 3.2.1.177 2026 # BioGrid 4262572 5 # CATALYTIC ACTIVITY Hydrolysis of terminal, non-reducing alpha-D- xylose residues with release of alpha-D-xylose. {ECO:0000269|PubMed 16631751}. # CAZy GH31 Glycoside Hydrolase Family 31 # EcoGene EG11685 yicI # FUNCTION XYLS_ECOLI Can catalyze the transfer of alpha-xylosyl residue from alpha-xyloside to xylose, glucose, mannose, fructose, maltose, isomaltose, nigerose, kojibiose, sucrose and trehalose. {ECO 0000269|PubMed 15294295, ECO 0000269|PubMed 15501829}. # GO_function GO:0030246 carbohydrate binding; IEA:InterPro. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0061634 alpha-D-xyloside xylohydrolase; IEA:UniProtKB-EC. # GO_function GO:0080176 xyloglucan 1,6-alpha-xylosidase activity; IDA:EcoCyc. # GO_process GO:0005975 carbohydrate metabolic process; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_process GO:0005975 carbohydrate metabolic process # Gene3D 3.20.20.70 -; 2. # IntAct P31434 2 # InterPro IPR000322 Glyco_hydro_31 # InterPro IPR011013 Gal_mutarotase_SF_dom # InterPro IPR013785 Aldolase_TIM # InterPro IPR017853 Glycoside_hydrolase_SF # InterPro IPR025887 Glyco_hydro_31_N_dom # KEGG_Brite ko01000 Enzymes # Organism XYLS_ECOLI Escherichia coli (strain K12) # PATRIC 32122799 VBIEscCol129921_3776 # PDB 1WE5 X-ray; 2.40 A; A/B/C/D/E/F=1-772 # PDB 1XSI X-ray; 2.20 A; A/B/C/D/E/F=1-772 # PDB 1XSJ X-ray; 2.10 A; A/B/C/D/E/F=1-772 # PDB 1XSK X-ray; 2.20 A; A/B/C/D/E/F=1-772 # PDB 2F2H X-ray; 1.95 A; A/B/C/D/E/F=1-772 # PIR B65167 B65167 # Pfam PF01055 Glyco_hydro_31 # Pfam PF13802 Gal_mutarotas_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName XYLS_ECOLI Alpha-xylosidase # RefSeq NP_418113 NC_000913.3 # RefSeq WP_000702898 NZ_LN832404.1 # SIMILARITY Belongs to the glycosyl hydrolase 31 family. {ECO 0000305}. # SUBUNIT XYLS_ECOLI Homohexamer. {ECO 0000269|PubMed 15294295, ECO 0000269|PubMed 15501829}. # SUPFAM SSF51445 SSF51445 # SUPFAM SSF74650 SSF74650 # eggNOG COG1501 LUCA # eggNOG ENOG4105CJQ Bacteria BLAST swissprot:XYLS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:XYLS_ECOLI BioCyc ECOL316407:JW3631-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3631-MONOMER BioCyc EcoCyc:EG11685-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11685-MONOMER BioCyc MetaCyc:EG11685-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11685-MONOMER COG CAZy: http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=CAZy: COG COG1501 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1501 COG GH31 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=GH31 DIP DIP-12433N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12433N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1016/j.febslet.2006.04.025 http://dx.doi.org/10.1016/j.febslet.2006.04.025 DOI 10.1016/j.pep.2004.05.008 http://dx.doi.org/10.1016/j.pep.2004.05.008 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M410468200 http://dx.doi.org/10.1074/jbc.M410468200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.2.1.177 http://www.genome.jp/dbget-bin/www_bget?EC:3.2.1.177 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.2.1.177 http://enzyme.expasy.org/EC/3.2.1.177 EchoBASE EB1636 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1636 EcoGene EG11685 http://www.ecogene.org/geneInfo.php?eg_id=EG11685 EnsemblBacteria AAC76680 http://www.ensemblgenomes.org/id/AAC76680 EnsemblBacteria AAC76680 http://www.ensemblgenomes.org/id/AAC76680 EnsemblBacteria BAE77637 http://www.ensemblgenomes.org/id/BAE77637 EnsemblBacteria BAE77637 http://www.ensemblgenomes.org/id/BAE77637 EnsemblBacteria BAE77637 http://www.ensemblgenomes.org/id/BAE77637 EnsemblBacteria b3656 http://www.ensemblgenomes.org/id/b3656 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0030246 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030246 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0061634 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061634 GO_function GO:0080176 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0080176 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 948169 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948169 HOGENOM HOG000221907 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000221907&db=HOGENOM6 InParanoid P31434 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31434 IntAct P31434 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31434* IntEnz 3.2.1.177 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.2.1.177 InterPro IPR000322 http://www.ebi.ac.uk/interpro/entry/IPR000322 InterPro IPR011013 http://www.ebi.ac.uk/interpro/entry/IPR011013 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR017853 http://www.ebi.ac.uk/interpro/entry/IPR017853 InterPro IPR025887 http://www.ebi.ac.uk/interpro/entry/IPR025887 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3631 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3631 KEGG_Gene eco:b3656 http://www.genome.jp/dbget-bin/www_bget?eco:b3656 KEGG_Orthology KO:K01811 http://www.genome.jp/dbget-bin/www_bget?KO:K01811 OMA WIYKRWV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WIYKRWV PDB 1WE5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1WE5 PDB 1XSI http://www.ebi.ac.uk/pdbe-srv/view/entry/1XSI PDB 1XSJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1XSJ PDB 1XSK http://www.ebi.ac.uk/pdbe-srv/view/entry/1XSK PDB 2F2H http://www.ebi.ac.uk/pdbe-srv/view/entry/2F2H PDBsum 1WE5 http://www.ebi.ac.uk/pdbsum/1WE5 PDBsum 1XSI http://www.ebi.ac.uk/pdbsum/1XSI PDBsum 1XSJ http://www.ebi.ac.uk/pdbsum/1XSJ PDBsum 1XSK http://www.ebi.ac.uk/pdbsum/1XSK PDBsum 2F2H http://www.ebi.ac.uk/pdbsum/2F2H PSORT swissprot:XYLS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:XYLS_ECOLI PSORT-B swissprot:XYLS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:XYLS_ECOLI PSORT2 swissprot:XYLS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:XYLS_ECOLI Pfam PF01055 http://pfam.xfam.org/family/PF01055 Pfam PF13802 http://pfam.xfam.org/family/PF13802 Phobius swissprot:XYLS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:XYLS_ECOLI PhylomeDB P31434 http://phylomedb.org/?seqid=P31434 ProteinModelPortal P31434 http://www.proteinmodelportal.org/query/uniprot/P31434 PubMed 15294295 http://www.ncbi.nlm.nih.gov/pubmed/15294295 PubMed 15501829 http://www.ncbi.nlm.nih.gov/pubmed/15501829 PubMed 16631751 http://www.ncbi.nlm.nih.gov/pubmed/16631751 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418113 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418113 RefSeq WP_000702898 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000702898 SMR P31434 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31434 STRING 511145.b3656 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3656&targetmode=cogs STRING CAZy: http://string-db.org/newstring_cgi/show_network_section.pl?identifier=CAZy:&targetmode=cogs STRING COG1501 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1501&targetmode=cogs STRING GH31 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=GH31&targetmode=cogs SUPFAM SSF51445 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51445 SUPFAM SSF74650 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF74650 UniProtKB XYLS_ECOLI http://www.uniprot.org/uniprot/XYLS_ECOLI UniProtKB-AC P31434 http://www.uniprot.org/uniprot/P31434 charge swissprot:XYLS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:XYLS_ECOLI eggNOG COG1501 http://eggnogapi.embl.de/nog_data/html/tree/COG1501 eggNOG ENOG4105CJQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CJQ epestfind swissprot:XYLS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:XYLS_ECOLI garnier swissprot:XYLS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:XYLS_ECOLI helixturnhelix swissprot:XYLS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:XYLS_ECOLI hmoment swissprot:XYLS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:XYLS_ECOLI iep swissprot:XYLS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:XYLS_ECOLI inforesidue swissprot:XYLS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:XYLS_ECOLI octanol swissprot:XYLS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:XYLS_ECOLI pepcoil swissprot:XYLS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:XYLS_ECOLI pepdigest swissprot:XYLS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:XYLS_ECOLI pepinfo swissprot:XYLS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:XYLS_ECOLI pepnet swissprot:XYLS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:XYLS_ECOLI pepstats swissprot:XYLS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:XYLS_ECOLI pepwheel swissprot:XYLS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:XYLS_ECOLI pepwindow swissprot:XYLS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:XYLS_ECOLI sigcleave swissprot:XYLS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:XYLS_ECOLI ## Database ID URL or Descriptions # AltName REA1_ECOLI RepFIC replication initiation protein # CAUTION Could be the product of a pseudogene. The protein is truncated by the insertion of transposon Tn1000. {ECO 0000305}. # GO_process GO:0006260 DNA replication; IEA:UniProtKB-KW. # GO_process GO:0006276 plasmid maintenance; IEA:UniProtKB-KW. # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # Organism REA1_ECOLI Escherichia coli (strain K12) # PIR D26870 D26870 # RecName REA1_ECOLI Putative defective replication initiation protein BLAST swissprot:REA1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:REA1_ECOLI EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL M16168 http://www.ebi.ac.uk/ena/data/view/M16168 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260 GO_process GO:0006276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006276 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 PSORT swissprot:REA1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:REA1_ECOLI PSORT-B swissprot:REA1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:REA1_ECOLI PSORT2 swissprot:REA1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:REA1_ECOLI Phobius swissprot:REA1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:REA1_ECOLI ProteinModelPortal P13960 http://www.proteinmodelportal.org/query/uniprot/P13960 PubMed 3032897 http://www.ncbi.nlm.nih.gov/pubmed/3032897 SMR P13960 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P13960 UniProtKB REA1_ECOLI http://www.uniprot.org/uniprot/REA1_ECOLI UniProtKB-AC P13960 http://www.uniprot.org/uniprot/P13960 charge swissprot:REA1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:REA1_ECOLI epestfind swissprot:REA1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:REA1_ECOLI garnier swissprot:REA1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:REA1_ECOLI helixturnhelix swissprot:REA1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:REA1_ECOLI hmoment swissprot:REA1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:REA1_ECOLI iep swissprot:REA1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:REA1_ECOLI inforesidue swissprot:REA1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:REA1_ECOLI octanol swissprot:REA1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:REA1_ECOLI pepcoil swissprot:REA1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:REA1_ECOLI pepdigest swissprot:REA1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:REA1_ECOLI pepinfo swissprot:REA1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:REA1_ECOLI pepnet swissprot:REA1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:REA1_ECOLI pepstats swissprot:REA1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:REA1_ECOLI pepwheel swissprot:REA1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:REA1_ECOLI pepwindow swissprot:REA1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:REA1_ECOLI sigcleave swissprot:REA1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:REA1_ECOLI ## Database ID URL or Descriptions # BioGrid 4259821 33 # EcoGene EG10927 sbcC # FUNCTION SBCC_ECOLI SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity. # GO_function GO:0004519 endonuclease activity; IEA:UniProtKB-KW. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0008296 3'-5'-exodeoxyribonuclease activity; IDA:EcoCyc. # GO_process GO:0000725 recombinational repair; IDA:EcoCyc. # GO_process GO:0006260 DNA replication; IEA:UniProtKB-KW. # GO_process GO:0006974 cellular response to DNA damage stimulus; IMP:EcoCyc. # GOslim_function GO:0004518 nuclease activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.300 -; 4. # INTERACTION SBCC_ECOLI P76092 ynbC; NbExp=2; IntAct=EBI-546919, EBI-544837; # IntAct P13458 6 # InterPro IPR004592 SbcC_gammaproteobac_type # InterPro IPR027050 SbcC # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko03400 DNA repair and recombination proteins # Organism SBCC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR32114 PTHR32114 # PATRIC 32115937 VBIEscCol129921_0410 # PIR JS0350 BVECSC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SBCC_ECOLI Nuclease SbcCD subunit C # RefSeq NP_414931 NC_000913.3 # RefSeq WP_000698951 NZ_LN832404.1 # SIMILARITY Belongs to the SMC family. SbcC subfamily. {ECO 0000305}. # SUBUNIT SBCC_ECOLI Heterodimer of SbcC and SbcD. # SUPFAM SSF52540 SSF52540; 4 # TIGRFAMs TIGR00618 sbcc # eggNOG COG0419 LUCA # eggNOG ENOG4105EYH Bacteria BLAST swissprot:SBCC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SBCC_ECOLI BioCyc ECOL316407:JW0387-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0387-MONOMER BioCyc EcoCyc:EG10927-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10927-MONOMER BioCyc MetaCyc:EG10927-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10927-MONOMER COG COG0419 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0419 DIP DIP-342N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-342N DOI 10.1007/BF00120998 http://dx.doi.org/10.1007/BF00120998 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2443.2000.00341.x http://dx.doi.org/10.1046/j.1365-2443.2000.00341.x DOI 10.1073/pnas.95.14.7969 http://dx.doi.org/10.1073/pnas.95.14.7969 DOI 10.1093/nar/17.20.8033 http://dx.doi.org/10.1093/nar/17.20.8033 DOI 10.1093/nar/27.4.1039 http://dx.doi.org/10.1093/nar/27.4.1039 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M64787 http://www.ebi.ac.uk/ena/data/view/M64787 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EMBL X15981 http://www.ebi.ac.uk/ena/data/view/X15981 EchoBASE EB0920 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0920 EcoGene EG10927 http://www.ecogene.org/geneInfo.php?eg_id=EG10927 EnsemblBacteria AAC73500 http://www.ensemblgenomes.org/id/AAC73500 EnsemblBacteria AAC73500 http://www.ensemblgenomes.org/id/AAC73500 EnsemblBacteria BAE76177 http://www.ensemblgenomes.org/id/BAE76177 EnsemblBacteria BAE76177 http://www.ensemblgenomes.org/id/BAE76177 EnsemblBacteria BAE76177 http://www.ensemblgenomes.org/id/BAE76177 EnsemblBacteria b0397 http://www.ensemblgenomes.org/id/b0397 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004519 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004519 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008296 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008296 GO_process GO:0000725 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000725 GO_process GO:0006260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 949076 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949076 HOGENOM HOG000280831 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000280831&db=HOGENOM6 InParanoid P13458 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P13458 IntAct P13458 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P13458* InterPro IPR004592 http://www.ebi.ac.uk/interpro/entry/IPR004592 InterPro IPR027050 http://www.ebi.ac.uk/interpro/entry/IPR027050 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW0387 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0387 KEGG_Gene eco:b0397 http://www.genome.jp/dbget-bin/www_bget?eco:b0397 KEGG_Orthology KO:K03546 http://www.genome.jp/dbget-bin/www_bget?KO:K03546 MINT MINT-1301497 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1301497 OMA VWLANQQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VWLANQQ PANTHER PTHR32114 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32114 PSORT swissprot:SBCC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SBCC_ECOLI PSORT-B swissprot:SBCC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SBCC_ECOLI PSORT2 swissprot:SBCC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SBCC_ECOLI Phobius swissprot:SBCC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SBCC_ECOLI PhylomeDB P13458 http://phylomedb.org/?seqid=P13458 ProteinModelPortal P13458 http://www.proteinmodelportal.org/query/uniprot/P13458 PubMed 10886369 http://www.ncbi.nlm.nih.gov/pubmed/10886369 PubMed 1490631 http://www.ncbi.nlm.nih.gov/pubmed/1490631 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1744033 http://www.ncbi.nlm.nih.gov/pubmed/1744033 PubMed 2530497 http://www.ncbi.nlm.nih.gov/pubmed/2530497 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9653124 http://www.ncbi.nlm.nih.gov/pubmed/9653124 PubMed 9927737 http://www.ncbi.nlm.nih.gov/pubmed/9927737 RefSeq NP_414931 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414931 RefSeq WP_000698951 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000698951 SMR P13458 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P13458 STRING 511145.b0397 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0397&targetmode=cogs STRING COG0419 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0419&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR00618 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00618 UniProtKB SBCC_ECOLI http://www.uniprot.org/uniprot/SBCC_ECOLI UniProtKB-AC P13458 http://www.uniprot.org/uniprot/P13458 charge swissprot:SBCC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SBCC_ECOLI eggNOG COG0419 http://eggnogapi.embl.de/nog_data/html/tree/COG0419 eggNOG ENOG4105EYH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EYH epestfind swissprot:SBCC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SBCC_ECOLI garnier swissprot:SBCC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SBCC_ECOLI helixturnhelix swissprot:SBCC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SBCC_ECOLI hmoment swissprot:SBCC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SBCC_ECOLI iep swissprot:SBCC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SBCC_ECOLI inforesidue swissprot:SBCC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SBCC_ECOLI octanol swissprot:SBCC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SBCC_ECOLI pepcoil swissprot:SBCC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SBCC_ECOLI pepdigest swissprot:SBCC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SBCC_ECOLI pepinfo swissprot:SBCC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SBCC_ECOLI pepnet swissprot:SBCC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SBCC_ECOLI pepstats swissprot:SBCC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SBCC_ECOLI pepwheel swissprot:SBCC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SBCC_ECOLI pepwindow swissprot:SBCC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SBCC_ECOLI sigcleave swissprot:SBCC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SBCC_ECOLI ## Database ID URL or Descriptions # AltName CYOD_ECOLI Cytochrome o ubiquinol oxidase subunit 4 # AltName CYOD_ECOLI Oxidase bo(3) subunit 4 # AltName CYOD_ECOLI Ubiquinol oxidase chain D # AltName CYOD_ECOLI Ubiquinol oxidase polypeptide IV # AltName CYOD_ECOLI Ubiquinol oxidase subunit 4 # BioGrid 4260871 202 # DISRUPTION PHENOTYPE CYOD_ECOLI Increased reduction of the ubiquinone pool (in aerobically grown minimal medium with glucose). {ECO 0000269|PubMed 19542282, ECO 0000269|PubMed 22843529}. # EcoGene EG10181 cyoD # FUNCTION CYOD_ECOLI Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron. {ECO 0000269|PubMed 19542282, ECO 0000269|PubMed 22843529, ECO 0000269|PubMed 6308657}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0009319 cytochrome o ubiquinol oxidase complex; IDA:EcoCyc. # GO_function GO:0008827 cytochrome o ubiquinol oxidase activity; IEA:InterPro. # GO_function GO:0009055 electron carrier activity; IDA:EcoCyc. # GO_function GO:0009486 cytochrome bo3 ubiquinol oxidase activity; IDA:EcoCyc. # GO_function GO:0015078 hydrogen ion transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0015453 oxidoreduction-driven active transmembrane transporter activity; IDA:EcoCyc. # GO_process GO:0009060 aerobic respiration; IMP:EcoCyc. # GO_process GO:0015990 electron transport coupled proton transport; IDA:EcoCyc. # GO_process GO:0019646 aerobic electron transport chain; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0055085 transmembrane transport # InterPro IPR005171 Cyt_c_oxidase_su4_prok # InterPro IPR014210 Cyt_o_ubiqinol_oxidase_su4 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Pathway ko00190 Oxidative phosphorylation # Organism CYOD_ECOLI Escherichia coli (strain K12) # PATRIC 32116009 VBIEscCol129921_0446 # PDB 1FFT X-ray; 3.50 A # PIR D42226 D42226 # Pfam PF03626 COX4_pro # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CYOD_ECOLI Cytochrome bo(3) ubiquinol oxidase subunit 4 # RefSeq NP_414963 NC_000913.3 # RefSeq WP_000019869 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40185.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the cytochrome c oxidase bacterial subunit 4 family. {ECO 0000305}. # SUBCELLULAR LOCATION CYOD_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT CYOD_ECOLI Heterooctamer of two A chains, two B chains, two C chains and two D chains. {ECO 0000269|PubMed 11017202, ECO 0000269|PubMed 6308657}. # TCDB 3.D.4.5 the proton-translocating cytochrome oxidase (cox) superfamily # TIGRFAMs TIGR02847 CyoD # eggNOG COG3125 LUCA # eggNOG ENOG41090KH Bacteria BLAST swissprot:CYOD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CYOD_ECOLI BioCyc ECOL316407:JW0419-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0419-MONOMER BioCyc EcoCyc:CYOD-MONOMER http://biocyc.org/getid?id=EcoCyc:CYOD-MONOMER BioCyc MetaCyc:CYOD-MONOMER http://biocyc.org/getid?id=MetaCyc:CYOD-MONOMER COG COG3125 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3125 DIP DIP-48238N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48238N DOI 10.1038/82824 http://dx.doi.org/10.1038/82824 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.80.16.4889 http://dx.doi.org/10.1073/pnas.80.16.4889 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AEM.01507-12 http://dx.doi.org/10.1128/AEM.01507-12 DOI 10.1128/JB.00562-09 http://dx.doi.org/10.1128/JB.00562-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J05492 http://www.ebi.ac.uk/ena/data/view/J05492 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EchoBASE EB0178 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0178 EcoGene EG10181 http://www.ecogene.org/geneInfo.php?eg_id=EG10181 EnsemblBacteria AAC73532 http://www.ensemblgenomes.org/id/AAC73532 EnsemblBacteria AAC73532 http://www.ensemblgenomes.org/id/AAC73532 EnsemblBacteria BAE76209 http://www.ensemblgenomes.org/id/BAE76209 EnsemblBacteria BAE76209 http://www.ensemblgenomes.org/id/BAE76209 EnsemblBacteria BAE76209 http://www.ensemblgenomes.org/id/BAE76209 EnsemblBacteria b0429 http://www.ensemblgenomes.org/id/b0429 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0009319 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009319 GO_function GO:0008827 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008827 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0009486 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009486 GO_function GO:0015078 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015078 GO_function GO:0015453 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015453 GO_process GO:0009060 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009060 GO_process GO:0015990 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015990 GO_process GO:0019646 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019646 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 944918 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944918 HOGENOM HOG000087516 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000087516&db=HOGENOM6 InParanoid P0ABJ6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABJ6 IntAct P0ABJ6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABJ6* InterPro IPR005171 http://www.ebi.ac.uk/interpro/entry/IPR005171 InterPro IPR014210 http://www.ebi.ac.uk/interpro/entry/IPR014210 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Gene ecj:JW0419 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0419 KEGG_Gene eco:b0429 http://www.genome.jp/dbget-bin/www_bget?eco:b0429 KEGG_Orthology KO:K02300 http://www.genome.jp/dbget-bin/www_bget?KO:K02300 KEGG_Pathway ko00190 http://www.genome.jp/kegg-bin/show_pathway?ko00190 OMA IVVHMVF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IVVHMVF PDB 1FFT http://www.ebi.ac.uk/pdbe-srv/view/entry/1FFT PDBsum 1FFT http://www.ebi.ac.uk/pdbsum/1FFT PSORT swissprot:CYOD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CYOD_ECOLI PSORT-B swissprot:CYOD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CYOD_ECOLI PSORT2 swissprot:CYOD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CYOD_ECOLI Pfam PF03626 http://pfam.xfam.org/family/PF03626 Phobius swissprot:CYOD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CYOD_ECOLI PhylomeDB P0ABJ6 http://phylomedb.org/?seqid=P0ABJ6 ProteinModelPortal P0ABJ6 http://www.proteinmodelportal.org/query/uniprot/P0ABJ6 PubMed 11017202 http://www.ncbi.nlm.nih.gov/pubmed/11017202 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19542282 http://www.ncbi.nlm.nih.gov/pubmed/19542282 PubMed 2162835 http://www.ncbi.nlm.nih.gov/pubmed/2162835 PubMed 2165491 http://www.ncbi.nlm.nih.gov/pubmed/2165491 PubMed 22843529 http://www.ncbi.nlm.nih.gov/pubmed/22843529 PubMed 6308657 http://www.ncbi.nlm.nih.gov/pubmed/6308657 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414963 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414963 RefSeq WP_000019869 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000019869 STRING 511145.b0429 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0429&targetmode=cogs STRING COG3125 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3125&targetmode=cogs TCDB 3.D.4.5 http://www.tcdb.org/search/result.php?tc=3.D.4.5 TIGRFAMs TIGR02847 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02847 UniProtKB CYOD_ECOLI http://www.uniprot.org/uniprot/CYOD_ECOLI UniProtKB-AC P0ABJ6 http://www.uniprot.org/uniprot/P0ABJ6 charge swissprot:CYOD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CYOD_ECOLI eggNOG COG3125 http://eggnogapi.embl.de/nog_data/html/tree/COG3125 eggNOG ENOG41090KH http://eggnogapi.embl.de/nog_data/html/tree/ENOG41090KH epestfind swissprot:CYOD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CYOD_ECOLI garnier swissprot:CYOD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CYOD_ECOLI helixturnhelix swissprot:CYOD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CYOD_ECOLI hmoment swissprot:CYOD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CYOD_ECOLI iep swissprot:CYOD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CYOD_ECOLI inforesidue swissprot:CYOD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CYOD_ECOLI octanol swissprot:CYOD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CYOD_ECOLI pepcoil swissprot:CYOD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CYOD_ECOLI pepdigest swissprot:CYOD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CYOD_ECOLI pepinfo swissprot:CYOD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CYOD_ECOLI pepnet swissprot:CYOD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CYOD_ECOLI pepstats swissprot:CYOD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CYOD_ECOLI pepwheel swissprot:CYOD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CYOD_ECOLI pepwindow swissprot:CYOD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CYOD_ECOLI sigcleave swissprot:CYOD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CYOD_ECOLI ## Database ID URL or Descriptions # BioGrid 4259788 5 # EcoGene EG14323 ykgJ # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051536 iron-sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0055114 oxidation-reduction process; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # IntAct P0AAL9 3 # InterPro IPR005358 Puta_zinc/iron-chelating_dom # Organism YKGJ_ECOLI Escherichia coli (strain K12) # PIR H64754 H64754 # Pfam PF03692 CxxCxxCC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YKGJ_ECOLI Uncharacterized protein YkgJ # RefSeq NP_414822 NC_000913.3 # RefSeq WP_001303809 NZ_LN832404.1 # SIMILARITY To A.calcoaceticus putative ferredoxin. {ECO 0000305}. # eggNOG COG0727 LUCA # eggNOG ENOG4105PI0 Bacteria BLAST swissprot:YKGJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YKGJ_ECOLI BioCyc ECOL316407:JW0282-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0282-MONOMER BioCyc EcoCyc:G6159-MONOMER http://biocyc.org/getid?id=EcoCyc:G6159-MONOMER COG COG0727 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0727 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB4069 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4069 EcoGene EG14323 http://www.ecogene.org/geneInfo.php?eg_id=EG14323 EnsemblBacteria AAC73391 http://www.ensemblgenomes.org/id/AAC73391 EnsemblBacteria AAC73391 http://www.ensemblgenomes.org/id/AAC73391 EnsemblBacteria BAE76072 http://www.ensemblgenomes.org/id/BAE76072 EnsemblBacteria BAE76072 http://www.ensemblgenomes.org/id/BAE76072 EnsemblBacteria BAE76072 http://www.ensemblgenomes.org/id/BAE76072 EnsemblBacteria b0288 http://www.ensemblgenomes.org/id/b0288 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051536 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051536 GO_process GO:0055114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 945905 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945905 HOGENOM HOG000117244 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117244&db=HOGENOM6 InParanoid P0AAL9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAL9 IntAct P0AAL9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAL9* InterPro IPR005358 http://www.ebi.ac.uk/interpro/entry/IPR005358 KEGG_Gene ecj:JW0282 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0282 KEGG_Gene eco:b0288 http://www.genome.jp/dbget-bin/www_bget?eco:b0288 KEGG_Orthology KO:K06940 http://www.genome.jp/dbget-bin/www_bget?KO:K06940 OMA SFYWSEA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SFYWSEA PSORT swissprot:YKGJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YKGJ_ECOLI PSORT-B swissprot:YKGJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YKGJ_ECOLI PSORT2 swissprot:YKGJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YKGJ_ECOLI Pfam PF03692 http://pfam.xfam.org/family/PF03692 Phobius swissprot:YKGJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YKGJ_ECOLI PhylomeDB P0AAL9 http://phylomedb.org/?seqid=P0AAL9 ProteinModelPortal P0AAL9 http://www.proteinmodelportal.org/query/uniprot/P0AAL9 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414822 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414822 RefSeq WP_001303809 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001303809 STRING 511145.b0288 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0288&targetmode=cogs STRING COG0727 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0727&targetmode=cogs UniProtKB YKGJ_ECOLI http://www.uniprot.org/uniprot/YKGJ_ECOLI UniProtKB-AC P0AAL9 http://www.uniprot.org/uniprot/P0AAL9 charge swissprot:YKGJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YKGJ_ECOLI eggNOG COG0727 http://eggnogapi.embl.de/nog_data/html/tree/COG0727 eggNOG ENOG4105PI0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105PI0 epestfind swissprot:YKGJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YKGJ_ECOLI garnier swissprot:YKGJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YKGJ_ECOLI helixturnhelix swissprot:YKGJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YKGJ_ECOLI hmoment swissprot:YKGJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YKGJ_ECOLI iep swissprot:YKGJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YKGJ_ECOLI inforesidue swissprot:YKGJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YKGJ_ECOLI octanol swissprot:YKGJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YKGJ_ECOLI pepcoil swissprot:YKGJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YKGJ_ECOLI pepdigest swissprot:YKGJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YKGJ_ECOLI pepinfo swissprot:YKGJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YKGJ_ECOLI pepnet swissprot:YKGJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YKGJ_ECOLI pepstats swissprot:YKGJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YKGJ_ECOLI pepwheel swissprot:YKGJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YKGJ_ECOLI pepwindow swissprot:YKGJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YKGJ_ECOLI sigcleave swissprot:YKGJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YKGJ_ECOLI ## Database ID URL or Descriptions # AltName INSB6_ECOLI IS1e # EcoGene EG40002 insB6 # FUNCTION INSB6_ECOLI Absolutely required for transposition of IS1. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # InterPro IPR005063 Transposase_27 # Organism INSB6_ECOLI Escherichia coli (strain K12) # PIR JN0135 JN0135 # Pfam PF03400 DDE_Tnp_IS1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSB6_ECOLI Insertion element IS1 6 protein InsB # RefSeq NP_414562 NC_000913.3 # RefSeq NP_416407 NC_000913.3 # RefSeq NP_417902 NC_000913.3 # RefSeq WP_001119362 NZ_LN832404.1 # SIMILARITY Belongs to the transposase 27 family. {ECO 0000305}. # eggNOG COG1662 LUCA BLAST swissprot:INSB6_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSB6_ECOLI COG COG1662 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1662 DOI 10.1016/0378-1119(91)90096-T http://dx.doi.org/10.1016/0378-1119(91)90096-T DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X52537 http://www.ebi.ac.uk/ena/data/view/X52537 EchoBASE EB4728 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4728 EcoGene EG40002 http://www.ecogene.org/geneInfo.php?eg_id=EG40002 EnsemblBacteria AAC76470 http://www.ensemblgenomes.org/id/AAC76470 EnsemblBacteria AAC76470 http://www.ensemblgenomes.org/id/AAC76470 EnsemblBacteria BAE77848 http://www.ensemblgenomes.org/id/BAE77848 EnsemblBacteria BAE77848 http://www.ensemblgenomes.org/id/BAE77848 EnsemblBacteria BAE77848 http://www.ensemblgenomes.org/id/BAE77848 EnsemblBacteria b3445 http://www.ensemblgenomes.org/id/b3445 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GeneID 24944608 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24944608 GeneID 944743 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944743 GeneID 945867 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945867 GeneID 947949 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947949 HOGENOM HOG000036821 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000036821&db=HOGENOM6 InParanoid P0CF29 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CF29 InterPro IPR005063 http://www.ebi.ac.uk/interpro/entry/IPR005063 KEGG_Gene ecj:JW3409 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3409 KEGG_Gene eco:b0021 http://www.genome.jp/dbget-bin/www_bget?eco:b0021 KEGG_Gene eco:b1893 http://www.genome.jp/dbget-bin/www_bget?eco:b1893 KEGG_Gene eco:b3445 http://www.genome.jp/dbget-bin/www_bget?eco:b3445 KEGG_Orthology KO:K07480 http://www.genome.jp/dbget-bin/www_bget?KO:K07480 PSORT swissprot:INSB6_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSB6_ECOLI PSORT-B swissprot:INSB6_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSB6_ECOLI PSORT2 swissprot:INSB6_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSB6_ECOLI Pfam PF03400 http://pfam.xfam.org/family/PF03400 Phobius swissprot:INSB6_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSB6_ECOLI PhylomeDB P0CF29 http://phylomedb.org/?seqid=P0CF29 ProteinModelPortal P0CF29 http://www.proteinmodelportal.org/query/uniprot/P0CF29 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1849492 http://www.ncbi.nlm.nih.gov/pubmed/1849492 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414562 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414562 RefSeq NP_416407 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416407 RefSeq NP_417902 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417902 RefSeq WP_001119362 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001119362 STRING 511145.b3445 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3445&targetmode=cogs STRING COG1662 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1662&targetmode=cogs UniProtKB INSB6_ECOLI http://www.uniprot.org/uniprot/INSB6_ECOLI UniProtKB-AC P0CF29 http://www.uniprot.org/uniprot/P0CF29 charge swissprot:INSB6_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSB6_ECOLI eggNOG COG1662 http://eggnogapi.embl.de/nog_data/html/tree/COG1662 epestfind swissprot:INSB6_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSB6_ECOLI garnier swissprot:INSB6_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSB6_ECOLI helixturnhelix swissprot:INSB6_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSB6_ECOLI hmoment swissprot:INSB6_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSB6_ECOLI iep swissprot:INSB6_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSB6_ECOLI inforesidue swissprot:INSB6_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSB6_ECOLI octanol swissprot:INSB6_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSB6_ECOLI pepcoil swissprot:INSB6_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSB6_ECOLI pepdigest swissprot:INSB6_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSB6_ECOLI pepinfo swissprot:INSB6_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSB6_ECOLI pepnet swissprot:INSB6_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSB6_ECOLI pepstats swissprot:INSB6_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSB6_ECOLI pepwheel swissprot:INSB6_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSB6_ECOLI pepwindow swissprot:INSB6_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSB6_ECOLI sigcleave swissprot:INSB6_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSB6_ECOLI ## Database ID URL or Descriptions # AltName TQSA_ECOLI Transport of quorum-sensing signal protein # BioGrid 4260647 14 # DISRUPTION PHENOTYPE Cells have a decreased extracellular and increased intracellular concentration of AI-2. Deletion of tqsA results in a 7000-fold increase in biofilm thickness and 574-fold increase in biomass in flow cells. Deletion of tqsA increases cell motility by increasing transcription of flagellar genes. The tqsA deletion mutant shows higher resistance toward crystal violet, spectinomycin, streptomycin sulfate, 2,6-dichloroquinone-4- chloroimide, chloramphenicol and amoxicillin. {ECO:0000269|PubMed 16385049}. # EcoGene EG13928 tqsA # FUNCTION TQSA_ECOLI Controls the transport of the quorum-sensing signal AI-2 either by enhancing its secretion or inhibiting its uptake and consequently represses biofilm formation and motility and affects the global gene expression in biofilms. {ECO 0000269|PubMed 16385049}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0015562 efflux transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0006810 transport; IMP:EcoCyc. # GO_process GO:0009372 quorum sensing; IMP:EcoCyc. # GO_process GO:0044010 single-species biofilm formation; IMP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # GOslim_process GO:0042592 homeostatic process # InterPro IPR002549 AI-2E-like # Organism TQSA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21716 PTHR21716 # PATRIC 32118504 VBIEscCol129921_1672 # PIR C64916 C64916 # Pfam PF01594 AI-2E_transport # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TQSA_ECOLI AI-2 transport protein TqsA # RefSeq NP_416118 NC_000913.3 # RefSeq WP_001118241 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0118 (PerM) family. {ECO 0000305}. # SUBCELLULAR LOCATION TQSA_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.86.1 the autoinducer-2 exporter (ai-2e) family (formerly the perm family, tc #9.b.22) # eggNOG COG0628 LUCA # eggNOG ENOG4105DSF Bacteria BLAST swissprot:TQSA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TQSA_ECOLI BioCyc ECOL316407:JW1593-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1593-MONOMER BioCyc EcoCyc:G6859-MONOMER http://biocyc.org/getid?id=EcoCyc:G6859-MONOMER BioCyc MetaCyc:G6859-MONOMER http://biocyc.org/getid?id=MetaCyc:G6859-MONOMER COG COG0628 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0628 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.188.2.587-598.2006 http://dx.doi.org/10.1128/JB.188.2.587-598.2006 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3687 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3687 EcoGene EG13928 http://www.ecogene.org/geneInfo.php?eg_id=EG13928 EnsemblBacteria AAC74673 http://www.ensemblgenomes.org/id/AAC74673 EnsemblBacteria AAC74673 http://www.ensemblgenomes.org/id/AAC74673 EnsemblBacteria BAA15335 http://www.ensemblgenomes.org/id/BAA15335 EnsemblBacteria BAA15335 http://www.ensemblgenomes.org/id/BAA15335 EnsemblBacteria BAA15335 http://www.ensemblgenomes.org/id/BAA15335 EnsemblBacteria b1601 http://www.ensemblgenomes.org/id/b1601 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015562 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015562 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GO_process GO:0009372 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009372 GO_process GO:0044010 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044010 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GeneID 946142 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946142 HOGENOM HOG000290196 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000290196&db=HOGENOM6 InParanoid P0AFS5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFS5 InterPro IPR002549 http://www.ebi.ac.uk/interpro/entry/IPR002549 KEGG_Gene ecj:JW1593 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1593 KEGG_Gene eco:b1601 http://www.genome.jp/dbget-bin/www_bget?eco:b1601 KEGG_Orthology KO:K11744 http://www.genome.jp/dbget-bin/www_bget?KO:K11744 OMA GMANIQR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GMANIQR PANTHER PTHR21716 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21716 PSORT swissprot:TQSA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TQSA_ECOLI PSORT-B swissprot:TQSA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TQSA_ECOLI PSORT2 swissprot:TQSA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TQSA_ECOLI Pfam PF01594 http://pfam.xfam.org/family/PF01594 Phobius swissprot:TQSA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TQSA_ECOLI PhylomeDB P0AFS5 http://phylomedb.org/?seqid=P0AFS5 ProteinModelPortal P0AFS5 http://www.proteinmodelportal.org/query/uniprot/P0AFS5 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16385049 http://www.ncbi.nlm.nih.gov/pubmed/16385049 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416118 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416118 RefSeq WP_001118241 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001118241 SMR P0AFS5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFS5 STRING 511145.b1601 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1601&targetmode=cogs STRING COG0628 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0628&targetmode=cogs TCDB 2.A.86.1 http://www.tcdb.org/search/result.php?tc=2.A.86.1 UniProtKB TQSA_ECOLI http://www.uniprot.org/uniprot/TQSA_ECOLI UniProtKB-AC P0AFS5 http://www.uniprot.org/uniprot/P0AFS5 charge swissprot:TQSA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TQSA_ECOLI eggNOG COG0628 http://eggnogapi.embl.de/nog_data/html/tree/COG0628 eggNOG ENOG4105DSF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DSF epestfind swissprot:TQSA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TQSA_ECOLI garnier swissprot:TQSA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TQSA_ECOLI helixturnhelix swissprot:TQSA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TQSA_ECOLI hmoment swissprot:TQSA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TQSA_ECOLI iep swissprot:TQSA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TQSA_ECOLI inforesidue swissprot:TQSA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TQSA_ECOLI octanol swissprot:TQSA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TQSA_ECOLI pepcoil swissprot:TQSA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TQSA_ECOLI pepdigest swissprot:TQSA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TQSA_ECOLI pepinfo swissprot:TQSA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TQSA_ECOLI pepnet swissprot:TQSA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TQSA_ECOLI pepstats swissprot:TQSA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TQSA_ECOLI pepwheel swissprot:TQSA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TQSA_ECOLI pepwindow swissprot:TQSA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TQSA_ECOLI sigcleave swissprot:TQSA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TQSA_ECOLI ## Database ID URL or Descriptions # AltName PLSY_ECOLI G3P acyltransferase # AltName PLSY_ECOLI Lysophosphatidic acid synthase # BioGrid 4259257 259 # CATALYTIC ACTIVITY Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1- acyl-sn-glycerol 3-phosphate. {ECO:0000269|PubMed 16949372}. # CATALYTIC ACTIVITY Acyl-[acyl-carrier-protein] + sn-glycerol 3- phosphate = [acyl-carrier-protein] + 1-acyl-sn-glycerol 3- phosphate. {ECO:0000269|PubMed 16949372}. # EcoGene EG11674 plsY # FUNCTION PLSY_ECOLI Catalyzes the transfer of an acyl group from acyl-ACP to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme can also utilize acyl-CoA as fatty acyl donor, but not acyl-PO(4) (Probable). {ECO 0000305|PubMed 17645809}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0004147 dihydrolipoamide branched chain acyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0004366 glycerol-3-phosphate O-acyltransferase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0008951 palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016406 carnitine O-acyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016411 acylglycerol O-acyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016412 serine O-acyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016413 O-acetyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016414 O-octanoyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016416 O-palmitoyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016418 S-acetyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016419 S-malonyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016454 C-palmitoyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016749 N-succinyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016750 O-succinyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016751 S-succinyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016753 O-sinapoyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0018030 peptidyl-lysine N6-myristoyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0018031 peptidyl-lysine N6-palmitoyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0018711 benzoyl acetate-CoA thiolase activity; IEA:UniProtKB-EC. # GO_function GO:0018712 3-hydroxybutyryl-CoA thiolase activity; IEA:UniProtKB-EC. # GO_function GO:0018713 3-ketopimelyl-CoA thiolase activity; IEA:UniProtKB-EC. # GO_function GO:0019186 acyl-CoA N-acyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0019705 protein-cysteine S-myristoyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0032216 glucosaminyl-phosphotidylinositol O-acyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0034737 ergosterol O-acyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0034738 lanosterol O-acyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0034848 naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity; IEA:UniProtKB-EC. # GO_function GO:0034851 2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity; IEA:UniProtKB-EC. # GO_function GO:0034915 2-methylhexanoyl-CoA C-acetyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0034919 butyryl-CoA 2-C-propionyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0034945 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0043741 L-2-aminoadipate N-acetyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0043772 acyl-phosphate glycerol-3-phosphate acyltransferase activity; IEA:InterPro. # GO_function GO:0043806 keto acid formate lyase activity; IEA:UniProtKB-EC. # GO_function GO:0043849 Ras palmitoyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0046941 azetidine-2-carboxylic acid acetyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0052858 peptidyl-lysine acetyltransferase activity; IEA:UniProtKB-EC. # GO_function PLSY_ECOLI GO 0090595 acetyl-CoA L-lysine N6-acetyltransferase; IEA UniProtKB-EC. # GO_process GO:0008654 phospholipid biosynthetic process; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # HAMAP MF_01043 PlsY # InterPro IPR003811 G3P_acylTferase_PlsY # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01004 Lipid biosynthesis proteins # KEGG_Pathway ko00561 Glycerolipid metabolism # KEGG_Pathway ko00564 Glycerophospholipid metabolism # Organism PLSY_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30309:SF0 PTHR30309:SF0 # PATHWAY PLSY_ECOLI Lipid metabolism; phospholipid metabolism. # PATRIC 32121530 VBIEscCol129921_3152 # PIR A65094 A65094 # Pfam PF02660 G3P_acyltransf # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PLSY_ECOLI Probable glycerol-3-phosphate acyltransferase # RefSeq NP_417531 NC_000913.3 # RefSeq WP_001272796 NZ_LN832404.1 # SIMILARITY Belongs to the PlsY family. {ECO 0000305}. # SMART SM01207 G3P_acyltransf # SUBCELLULAR LOCATION PLSY_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT Probably interacts with PlsX. {ECO 0000250}. # TCDB 9.B.31.1 the yqih (yqih) family # TIGRFAMs TIGR00023 TIGR00023 # eggNOG COG0344 LUCA # eggNOG ENOG4105K7Z Bacteria BLAST swissprot:PLSY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PLSY_ECOLI BioCyc ECOL316407:JW3031-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3031-MONOMER BioCyc EcoCyc:EG11674-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11674-MONOMER COG COG0344 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0344 DOI 10.1016/j.molcel.2006.06.030 http://dx.doi.org/10.1016/j.molcel.2006.06.030 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1186/1471-2180-7-69 http://dx.doi.org/10.1186/1471-2180-7-69 EC_number EC:2.3.1.15 http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.15 EC_number EC:2.3.1.n5 http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.n5 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L12966 http://www.ebi.ac.uk/ena/data/view/L12966 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28379 http://www.ebi.ac.uk/ena/data/view/U28379 ENZYME 2.3.1.15 http://enzyme.expasy.org/EC/2.3.1.15 ENZYME 2.3.1.n5 http://enzyme.expasy.org/EC/2.3.1.n5 EchoBASE EB1625 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1625 EcoGene EG11674 http://www.ecogene.org/geneInfo.php?eg_id=EG11674 EnsemblBacteria AAC76095 http://www.ensemblgenomes.org/id/AAC76095 EnsemblBacteria AAC76095 http://www.ensemblgenomes.org/id/AAC76095 EnsemblBacteria BAE77110 http://www.ensemblgenomes.org/id/BAE77110 EnsemblBacteria BAE77110 http://www.ensemblgenomes.org/id/BAE77110 EnsemblBacteria BAE77110 http://www.ensemblgenomes.org/id/BAE77110 EnsemblBacteria b3059 http://www.ensemblgenomes.org/id/b3059 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0004147 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004147 GO_function GO:0004366 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004366 GO_function GO:0008951 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008951 GO_function GO:0016406 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016406 GO_function GO:0016411 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016411 GO_function GO:0016412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016412 GO_function GO:0016413 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016413 GO_function GO:0016414 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016414 GO_function GO:0016416 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016416 GO_function GO:0016418 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016418 GO_function GO:0016419 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016419 GO_function GO:0016454 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016454 GO_function GO:0016749 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016749 GO_function GO:0016750 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016750 GO_function GO:0016751 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016751 GO_function GO:0016753 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016753 GO_function GO:0018030 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018030 GO_function GO:0018031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018031 GO_function GO:0018711 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018711 GO_function GO:0018712 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018712 GO_function GO:0018713 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018713 GO_function GO:0019186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019186 GO_function GO:0019705 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019705 GO_function GO:0032216 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032216 GO_function GO:0034737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034737 GO_function GO:0034738 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034738 GO_function GO:0034848 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034848 GO_function GO:0034851 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034851 GO_function GO:0034915 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034915 GO_function GO:0034919 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034919 GO_function GO:0034945 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034945 GO_function GO:0043741 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043741 GO_function GO:0043772 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043772 GO_function GO:0043806 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043806 GO_function GO:0043849 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043849 GO_function GO:0046941 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046941 GO_function GO:0052858 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052858 GO_function GO:0090595 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090595 GO_process GO:0008654 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008654 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 947561 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947561 HAMAP MF_01043 http://hamap.expasy.org/unirule/MF_01043 HOGENOM HOG000283806 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000283806&db=HOGENOM6 InParanoid P60782 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P60782 IntAct P60782 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P60782* IntEnz 2.3.1.15 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.15 IntEnz 2.3.1.n5 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.n5 InterPro IPR003811 http://www.ebi.ac.uk/interpro/entry/IPR003811 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01004 http://www.genome.jp/dbget-bin/www_bget?ko01004 KEGG_Gene ecj:JW3031 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3031 KEGG_Gene eco:b3059 http://www.genome.jp/dbget-bin/www_bget?eco:b3059 KEGG_Orthology KO:K08591 http://www.genome.jp/dbget-bin/www_bget?KO:K08591 KEGG_Pathway ko00561 http://www.genome.jp/kegg-bin/show_pathway?ko00561 KEGG_Pathway ko00564 http://www.genome.jp/kegg-bin/show_pathway?ko00564 KEGG_Reaction rn:R00851 http://www.genome.jp/dbget-bin/www_bget?rn:R00851 KEGG_Reaction rn:R09380 http://www.genome.jp/dbget-bin/www_bget?rn:R09380 OMA HIWPVWL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HIWPVWL PANTHER PTHR30309:SF0 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30309:SF0 PSORT swissprot:PLSY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PLSY_ECOLI PSORT-B swissprot:PLSY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PLSY_ECOLI PSORT2 swissprot:PLSY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PLSY_ECOLI Pfam PF02660 http://pfam.xfam.org/family/PF02660 Phobius swissprot:PLSY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PLSY_ECOLI PhylomeDB P60782 http://phylomedb.org/?seqid=P60782 ProteinModelPortal P60782 http://www.proteinmodelportal.org/query/uniprot/P60782 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16949372 http://www.ncbi.nlm.nih.gov/pubmed/16949372 PubMed 17645809 http://www.ncbi.nlm.nih.gov/pubmed/17645809 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 8389741 http://www.ncbi.nlm.nih.gov/pubmed/8389741 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417531 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417531 RefSeq WP_001272796 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001272796 SMART SM01207 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01207 STRING 511145.b3059 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3059&targetmode=cogs STRING COG0344 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0344&targetmode=cogs TCDB 9.B.31.1 http://www.tcdb.org/search/result.php?tc=9.B.31.1 TIGRFAMs TIGR00023 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00023 UniProtKB PLSY_ECOLI http://www.uniprot.org/uniprot/PLSY_ECOLI UniProtKB-AC P60782 http://www.uniprot.org/uniprot/P60782 charge swissprot:PLSY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PLSY_ECOLI eggNOG COG0344 http://eggnogapi.embl.de/nog_data/html/tree/COG0344 eggNOG ENOG4105K7Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K7Z epestfind swissprot:PLSY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PLSY_ECOLI garnier swissprot:PLSY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PLSY_ECOLI helixturnhelix swissprot:PLSY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PLSY_ECOLI hmoment swissprot:PLSY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PLSY_ECOLI iep swissprot:PLSY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PLSY_ECOLI inforesidue swissprot:PLSY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PLSY_ECOLI octanol swissprot:PLSY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PLSY_ECOLI pepcoil swissprot:PLSY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PLSY_ECOLI pepdigest swissprot:PLSY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PLSY_ECOLI pepinfo swissprot:PLSY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PLSY_ECOLI pepnet swissprot:PLSY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PLSY_ECOLI pepstats swissprot:PLSY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PLSY_ECOLI pepwheel swissprot:PLSY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PLSY_ECOLI pepwindow swissprot:PLSY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PLSY_ECOLI sigcleave swissprot:PLSY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PLSY_ECOLI ## Database ID URL or Descriptions # BioGrid 4262541 7 # EcoGene EG20252 xylF # FUNCTION XYLF_ECOLI Involved in the high-affinity D-xylose membrane transport system. Binds with high affinity to xylose. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0048029 monosaccharide binding; IMP:EcoCyc. # GO_process GO:0015753 D-xylose transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006810 transport # IntAct P37387 4 # InterPro IPR013456 XylF # InterPro IPR025997 SBP_2_dom # InterPro IPR028082 Peripla_BP_I # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00215 D-Xylose transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # MISCELLANEOUS E.coli has two D-xylose transport systems that accumulate sugar against a concentration gradient the XylE system which utilizes the electrochemical gradient of protons and that is insensitive to cold osmotic shock and the XylF system that uses a high-energy phosphate compound and is sensitive to cold osmotic shock. # Organism XYLF_ECOLI Escherichia coli (strain K12) # PATRIC 32122608 VBIEscCol129921_3681 # PDB 3M9W X-ray; 2.15 A; A=24-330 # PDB 3M9X X-ray; 2.20 A; A=24-330 # PDB 3MA0 X-ray; 2.20 A; A/B/C=24-330 # PIR S47787 S47787 # Pfam PF13407 Peripla_BP_4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName XYLF_ECOLI D-xylose-binding periplasmic protein # RefSeq NP_418023 NC_000913.3 # RefSeq WP_000694881 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial solute-binding protein 2 family. {ECO 0000305}. # SUBCELLULAR LOCATION XYLF_ECOLI Periplasm. # SUPFAM SSF53822 SSF53822 # TCDB 3.A.1.2 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR02634 xylF # eggNOG COG4213 LUCA # eggNOG ENOG4105DFW Bacteria BLAST swissprot:XYLF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:XYLF_ECOLI BioCyc ECOL316407:JW3538-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3538-MONOMER BioCyc EcoCyc:XYLF-MONOMER http://biocyc.org/getid?id=EcoCyc:XYLF-MONOMER BioCyc MetaCyc:XYLF-MONOMER http://biocyc.org/getid?id=MetaCyc:XYLF-MONOMER COG COG4213 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4213 DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4153 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4153 EcoGene EG20252 http://www.ecogene.org/geneInfo.php?eg_id=EG20252 EnsemblBacteria AAC76590 http://www.ensemblgenomes.org/id/AAC76590 EnsemblBacteria AAC76590 http://www.ensemblgenomes.org/id/AAC76590 EnsemblBacteria BAE77727 http://www.ensemblgenomes.org/id/BAE77727 EnsemblBacteria BAE77727 http://www.ensemblgenomes.org/id/BAE77727 EnsemblBacteria BAE77727 http://www.ensemblgenomes.org/id/BAE77727 EnsemblBacteria b3566 http://www.ensemblgenomes.org/id/b3566 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0048029 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048029 GO_process GO:0015753 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015753 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948090 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948090 HOGENOM HOG000240882 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000240882&db=HOGENOM6 InParanoid P37387 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37387 IntAct P37387 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37387* InterPro IPR013456 http://www.ebi.ac.uk/interpro/entry/IPR013456 InterPro IPR025997 http://www.ebi.ac.uk/interpro/entry/IPR025997 InterPro IPR028082 http://www.ebi.ac.uk/interpro/entry/IPR028082 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3538 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3538 KEGG_Gene eco:b3566 http://www.genome.jp/dbget-bin/www_bget?eco:b3566 KEGG_Orthology KO:K10543 http://www.genome.jp/dbget-bin/www_bget?KO:K10543 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA QQWVPEW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QQWVPEW PDB 3M9W http://www.ebi.ac.uk/pdbe-srv/view/entry/3M9W PDB 3M9X http://www.ebi.ac.uk/pdbe-srv/view/entry/3M9X PDB 3MA0 http://www.ebi.ac.uk/pdbe-srv/view/entry/3MA0 PDBsum 3M9W http://www.ebi.ac.uk/pdbsum/3M9W PDBsum 3M9X http://www.ebi.ac.uk/pdbsum/3M9X PDBsum 3MA0 http://www.ebi.ac.uk/pdbsum/3MA0 PSORT swissprot:XYLF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:XYLF_ECOLI PSORT-B swissprot:XYLF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:XYLF_ECOLI PSORT2 swissprot:XYLF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:XYLF_ECOLI Pfam PF13407 http://pfam.xfam.org/family/PF13407 Phobius swissprot:XYLF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:XYLF_ECOLI PhylomeDB P37387 http://phylomedb.org/?seqid=P37387 ProteinModelPortal P37387 http://www.proteinmodelportal.org/query/uniprot/P37387 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 8581399 http://www.ncbi.nlm.nih.gov/pubmed/8581399 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_418023 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418023 RefSeq WP_000694881 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000694881 SMR P37387 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37387 STRING 511145.b3566 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3566&targetmode=cogs STRING COG4213 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4213&targetmode=cogs SUPFAM SSF53822 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822 TCDB 3.A.1.2 http://www.tcdb.org/search/result.php?tc=3.A.1.2 TIGRFAMs TIGR02634 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02634 UniProtKB XYLF_ECOLI http://www.uniprot.org/uniprot/XYLF_ECOLI UniProtKB-AC P37387 http://www.uniprot.org/uniprot/P37387 charge swissprot:XYLF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:XYLF_ECOLI eggNOG COG4213 http://eggnogapi.embl.de/nog_data/html/tree/COG4213 eggNOG ENOG4105DFW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DFW epestfind swissprot:XYLF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:XYLF_ECOLI garnier swissprot:XYLF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:XYLF_ECOLI helixturnhelix swissprot:XYLF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:XYLF_ECOLI hmoment swissprot:XYLF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:XYLF_ECOLI iep swissprot:XYLF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:XYLF_ECOLI inforesidue swissprot:XYLF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:XYLF_ECOLI octanol swissprot:XYLF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:XYLF_ECOLI pepcoil swissprot:XYLF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:XYLF_ECOLI pepdigest swissprot:XYLF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:XYLF_ECOLI pepinfo swissprot:XYLF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:XYLF_ECOLI pepnet swissprot:XYLF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:XYLF_ECOLI pepstats swissprot:XYLF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:XYLF_ECOLI pepwheel swissprot:XYLF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:XYLF_ECOLI pepwindow swissprot:XYLF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:XYLF_ECOLI sigcleave swissprot:XYLF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:XYLF_ECOLI ## Database ID URL or Descriptions # AltName ATP synthase F0 sector subunit a {ECO:0000255|HAMAP-Rule MF_01393} # AltName F-ATPase subunit 6 {ECO:0000255|HAMAP-Rule MF_01393} # CAUTION Was originally proposed to be encoded from either Met-1 or Val-71 (PID CAA23521); it is now thought to start of Met-1. {ECO:0000305|PubMed 6278247}. # EcoGene EG10099 atpB # FUNCTION ATP6_ECOLI Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IDA:EcoliWiki. # GO_component GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o); IMP:EcoCyc. # GO_function GO:0046933 proton-transporting ATP synthase activity, rotational mechanism; IMP:EcoCyc. # GO_process GO:0042777 plasma membrane ATP synthesis coupled proton transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0055085 transmembrane transport # Gene3D 1.20.120.220 -; 1. # HAMAP MF_01393 ATP_synth_a_bact # IntAct P0AB98 2 # InterPro IPR000568 ATP_synth_F0_asu # InterPro IPR023011 ATP_synth_F0_asu_AS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko00194 Photosynthesis proteins # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03110 Chaperones and folding catalysts # KEGG_Pathway ko00190 Oxidative phosphorylation # KEGG_Pathway ko00195 Photosynthesis # Organism ATP6_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11410 PTHR11410; 2 # PATRIC 32122973 VBIEscCol129921_3862 # PDB 1C17 NMR; -; M=95-271 # PIR C93732 LWEC6 # PRINTS PR00123 ATPASEA # PROSITE PS00449 ATPASE_A # Pfam PF00119 ATP-synt_A # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ATP synthase subunit a {ECO:0000255|HAMAP-Rule MF_01393} # RefSeq NP_418194 NC_000913.3 # RefSeq WP_000135625 NZ_CP014272.1 # SIMILARITY Belongs to the ATPase A chain family. {ECO:0000255|HAMAP-Rule MF_01393}. # SUBCELLULAR LOCATION ATP6_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01393, ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255|HAMAP-Rule MF_01393, ECO 0000269|PubMed 15919996}. # SUBUNIT F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains. # SUPFAM SSF81336 SSF81336 # TCDB 3.A.2.1 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily # TIGRFAMs TIGR01131 ATP_synt_6_or_A # eggNOG COG0356 LUCA # eggNOG ENOG4105EE4 Bacteria BLAST swissprot:ATP6_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ATP6_ECOLI BioCyc ECOL316407:JW3716-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3716-MONOMER BioCyc EcoCyc:ATPB-MONOMER http://biocyc.org/getid?id=EcoCyc:ATPB-MONOMER BioCyc MetaCyc:ATPB-MONOMER http://biocyc.org/getid?id=MetaCyc:ATPB-MONOMER COG COG0356 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0356 DIP DIP-47956N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47956N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1007/BF00271191 http://dx.doi.org/10.1007/BF00271191 DOI 10.1007/BF00327415 http://dx.doi.org/10.1007/BF00327415 DOI 10.1016/0006-291X(81)90495-2 http://dx.doi.org/10.1016/0006-291X(81)90495-2 DOI 10.1016/0014-5793(90)80058-Q http://dx.doi.org/10.1016/0014-5793(90)80058-Q DOI 10.1016/0014-5793(96)00621-7 http://dx.doi.org/10.1016/0014-5793(96)00621-7 DOI 10.1038/46224 http://dx.doi.org/10.1038/46224 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2240799 http://dx.doi.org/10.1042/bj2240799 DOI 10.1074/jbc.273.26.16241 http://dx.doi.org/10.1074/jbc.273.26.16241 DOI 10.1093/nar/9.16.3919 http://dx.doi.org/10.1093/nar/9.16.3919 DOI 10.1111/j.1749-6632.1982.tb25731.x http://dx.doi.org/10.1111/j.1749-6632.1982.tb25731.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01594 http://www.ebi.ac.uk/ena/data/view/J01594 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M14019 http://www.ebi.ac.uk/ena/data/view/M14019 EMBL M25464 http://www.ebi.ac.uk/ena/data/view/M25464 EMBL M29174 http://www.ebi.ac.uk/ena/data/view/M29174 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00264 http://www.ebi.ac.uk/ena/data/view/V00264 EMBL V00266 http://www.ebi.ac.uk/ena/data/view/V00266 EMBL V00266 http://www.ebi.ac.uk/ena/data/view/V00266 EMBL V00310 http://www.ebi.ac.uk/ena/data/view/V00310 EMBL X01383 http://www.ebi.ac.uk/ena/data/view/X01383 EMBL X01631 http://www.ebi.ac.uk/ena/data/view/X01631 EchoBASE EB0097 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0097 EcoGene EG10099 http://www.ecogene.org/geneInfo.php?eg_id=EG10099 EnsemblBacteria AAC76761 http://www.ensemblgenomes.org/id/AAC76761 EnsemblBacteria AAC76761 http://www.ensemblgenomes.org/id/AAC76761 EnsemblBacteria BAE77550 http://www.ensemblgenomes.org/id/BAE77550 EnsemblBacteria BAE77550 http://www.ensemblgenomes.org/id/BAE77550 EnsemblBacteria BAE77550 http://www.ensemblgenomes.org/id/BAE77550 EnsemblBacteria b3738 http://www.ensemblgenomes.org/id/b3738 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0045263 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045263 GO_function GO:0046933 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046933 GO_process GO:0042777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042777 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 1.20.120.220 http://www.cathdb.info/version/latest/superfamily/1.20.120.220 GeneID 948252 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948252 HAMAP MF_01393 http://hamap.expasy.org/unirule/MF_01393 HOGENOM HOG000253872 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000253872&db=HOGENOM6 InParanoid P0AB98 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AB98 IntAct P0AB98 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AB98* InterPro IPR000568 http://www.ebi.ac.uk/interpro/entry/IPR000568 InterPro IPR023011 http://www.ebi.ac.uk/interpro/entry/IPR023011 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko00194 http://www.genome.jp/dbget-bin/www_bget?ko00194 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW3716 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3716 KEGG_Gene eco:b3738 http://www.genome.jp/dbget-bin/www_bget?eco:b3738 KEGG_Orthology KO:K02108 http://www.genome.jp/dbget-bin/www_bget?KO:K02108 KEGG_Pathway ko00190 http://www.genome.jp/kegg-bin/show_pathway?ko00190 KEGG_Pathway ko00195 http://www.genome.jp/kegg-bin/show_pathway?ko00195 MINT MINT-1300501 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1300501 OMA QIMITFS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QIMITFS PANTHER PTHR11410 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11410 PDB 1C17 http://www.ebi.ac.uk/pdbe-srv/view/entry/1C17 PDBsum 1C17 http://www.ebi.ac.uk/pdbsum/1C17 PRINTS PR00123 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00123 PROSITE PS00449 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00449 PSORT swissprot:ATP6_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ATP6_ECOLI PSORT-B swissprot:ATP6_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ATP6_ECOLI PSORT2 swissprot:ATP6_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ATP6_ECOLI Pfam PF00119 http://pfam.xfam.org/family/PF00119 Phobius swissprot:ATP6_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ATP6_ECOLI PhylomeDB P0AB98 http://phylomedb.org/?seqid=P0AB98 ProteinModelPortal P0AB98 http://www.proteinmodelportal.org/query/uniprot/P0AB98 PubMed 10580496 http://www.ncbi.nlm.nih.gov/pubmed/10580496 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1829729 http://www.ncbi.nlm.nih.gov/pubmed/1829729 PubMed 2137094 http://www.ncbi.nlm.nih.gov/pubmed/2137094 PubMed 2162353 http://www.ncbi.nlm.nih.gov/pubmed/2162353 PubMed 2536742 http://www.ncbi.nlm.nih.gov/pubmed/2536742 PubMed 2874136 http://www.ncbi.nlm.nih.gov/pubmed/2874136 PubMed 2874137 http://www.ncbi.nlm.nih.gov/pubmed/2874137 PubMed 6272190 http://www.ncbi.nlm.nih.gov/pubmed/6272190 PubMed 6277311 http://www.ncbi.nlm.nih.gov/pubmed/6277311 PubMed 6278247 http://www.ncbi.nlm.nih.gov/pubmed/6278247 PubMed 6301339 http://www.ncbi.nlm.nih.gov/pubmed/6301339 PubMed 6318052 http://www.ncbi.nlm.nih.gov/pubmed/6318052 PubMed 6325392 http://www.ncbi.nlm.nih.gov/pubmed/6325392 PubMed 6395859 http://www.ncbi.nlm.nih.gov/pubmed/6395859 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 8706824 http://www.ncbi.nlm.nih.gov/pubmed/8706824 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9632683 http://www.ncbi.nlm.nih.gov/pubmed/9632683 RefSeq NP_418194 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418194 RefSeq WP_000135625 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000135625 SMR P0AB98 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AB98 STRING 511145.b3738 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3738&targetmode=cogs STRING COG0356 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0356&targetmode=cogs SUPFAM SSF81336 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81336 TCDB 3.A.2.1 http://www.tcdb.org/search/result.php?tc=3.A.2.1 TIGRFAMs TIGR01131 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01131 UniProtKB ATP6_ECOLI http://www.uniprot.org/uniprot/ATP6_ECOLI UniProtKB-AC P0AB98 http://www.uniprot.org/uniprot/P0AB98 charge swissprot:ATP6_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ATP6_ECOLI eggNOG COG0356 http://eggnogapi.embl.de/nog_data/html/tree/COG0356 eggNOG ENOG4105EE4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EE4 epestfind swissprot:ATP6_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ATP6_ECOLI garnier swissprot:ATP6_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ATP6_ECOLI helixturnhelix swissprot:ATP6_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ATP6_ECOLI hmoment swissprot:ATP6_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ATP6_ECOLI iep swissprot:ATP6_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ATP6_ECOLI inforesidue swissprot:ATP6_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ATP6_ECOLI octanol swissprot:ATP6_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ATP6_ECOLI pepcoil swissprot:ATP6_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ATP6_ECOLI pepdigest swissprot:ATP6_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ATP6_ECOLI pepinfo swissprot:ATP6_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ATP6_ECOLI pepnet swissprot:ATP6_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ATP6_ECOLI pepstats swissprot:ATP6_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ATP6_ECOLI pepwheel swissprot:ATP6_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ATP6_ECOLI pepwindow swissprot:ATP6_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ATP6_ECOLI sigcleave swissprot:ATP6_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ATP6_ECOLI ## Database ID URL or Descriptions # AltName DNA-invertase PinR {ECO 0000305} # AltName PINR_ECOLI Putative DNA-invertase from lambdoid prophage Rac # AltName Site-specific recombinase PinR {ECO 0000305} # BioGrid 4263521 165 # EcoGene EG13372 pinR # GO_function GO:0000150 recombinase activity; IBA:GO_Central. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0016787 hydrolase activity; IEA:UniProtKB-KW. # GO_function GO:0016874 ligase activity; IEA:UniProtKB-KW. # GO_process GO:0015074 DNA integration; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016874 ligase activity # GOslim_process GO:0006259 DNA metabolic process # Gene3D 1.10.10.60 -; 1. # Gene3D 3.40.50.1390 -; 1. # INTERACTION PINR_ECOLI P06959 aceF; NbExp=2; IntAct=EBI-544672, EBI-542707; # IntAct P0ADI0 9 # InterPro IPR006118 Recombinase_CS # InterPro IPR006119 Resolv_N # InterPro IPR006120 Resolvase_HTH_dom # InterPro IPR009057 Homeodomain-like # Organism PINR_ECOLI Escherichia coli (strain K12) # PATRIC 32118030 VBIEscCol129921_1435 # PIR A64888 A64888 # PROSITE PS00398 RECOMBINASES_2 # PROSITE PS51736 RECOMBINASES_3 # Pfam PF00239 Resolvase # Pfam PF02796 HTH_7 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Serine recombinase PinR {ECO:0000250|UniProtKB P03015} # RefSeq NP_415892 NC_000913.3 # RefSeq WP_000086527 NZ_CP014272.1 # SIMILARITY Belongs to the site-specific recombinase resolvase family. {ECO 0000305}. # SIMILARITY Contains 1 resolvase/invertase-type recombinase catalytic domain. {ECO:0000255|PROSITE-ProRule PRU01072}. # SMART SM00857 Resolvase # SUPFAM SSF46689 SSF46689 # SUPFAM SSF53041 SSF53041 # eggNOG COG1961 LUCA # eggNOG ENOG4105MN3 Bacteria BLAST swissprot:PINR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PINR_ECOLI BioCyc ECOL316407:JW1368-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1368-MONOMER BioCyc EcoCyc:G6697-MONOMER http://biocyc.org/getid?id=EcoCyc:G6697-MONOMER COG COG1961 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1961 DIP DIP-47969N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47969N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.22.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.22.- EC_number EC:6.5.1.- http://www.genome.jp/dbget-bin/www_bget?EC:6.5.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.22.- http://enzyme.expasy.org/EC/3.1.22.- ENZYME 6.5.1.- http://enzyme.expasy.org/EC/6.5.1.- EchoBASE EB3154 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3154 EcoGene EG13372 http://www.ecogene.org/geneInfo.php?eg_id=EG13372 EnsemblBacteria AAC74456 http://www.ensemblgenomes.org/id/AAC74456 EnsemblBacteria AAC74456 http://www.ensemblgenomes.org/id/AAC74456 EnsemblBacteria BAA14979 http://www.ensemblgenomes.org/id/BAA14979 EnsemblBacteria BAA14979 http://www.ensemblgenomes.org/id/BAA14979 EnsemblBacteria BAA14979 http://www.ensemblgenomes.org/id/BAA14979 EnsemblBacteria b1374 http://www.ensemblgenomes.org/id/b1374 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000150 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0016787 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016787 GO_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GO_process GO:0015074 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015074 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 Gene3D 3.40.50.1390 http://www.cathdb.info/version/latest/superfamily/3.40.50.1390 GeneID 948973 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948973 HOGENOM HOG000275578 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275578&db=HOGENOM6 InParanoid P0ADI0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADI0 IntAct P0ADI0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADI0* IntEnz 3.1.22 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.22 IntEnz 6.5.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.5.1 InterPro IPR006118 http://www.ebi.ac.uk/interpro/entry/IPR006118 InterPro IPR006119 http://www.ebi.ac.uk/interpro/entry/IPR006119 InterPro IPR006120 http://www.ebi.ac.uk/interpro/entry/IPR006120 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 KEGG_Gene ecj:JW1368 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1368 KEGG_Gene eco:b1374 http://www.genome.jp/dbget-bin/www_bget?eco:b1374 KEGG_Orthology KO:K14060 http://www.genome.jp/dbget-bin/www_bget?KO:K14060 OMA WFADIVS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WFADIVS PROSITE PS00398 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00398 PROSITE PS51736 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51736 PSORT swissprot:PINR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PINR_ECOLI PSORT-B swissprot:PINR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PINR_ECOLI PSORT2 swissprot:PINR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PINR_ECOLI Pfam PF00239 http://pfam.xfam.org/family/PF00239 Pfam PF02796 http://pfam.xfam.org/family/PF02796 Phobius swissprot:PINR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PINR_ECOLI PhylomeDB P0ADI0 http://phylomedb.org/?seqid=P0ADI0 ProteinModelPortal P0ADI0 http://www.proteinmodelportal.org/query/uniprot/P0ADI0 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415892 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415892 RefSeq WP_000086527 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000086527 SMART SM00857 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00857 SMR P0ADI0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADI0 STRING 511145.b1374 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1374&targetmode=cogs STRING COG1961 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1961&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF53041 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53041 UniProtKB PINR_ECOLI http://www.uniprot.org/uniprot/PINR_ECOLI UniProtKB-AC P0ADI0 http://www.uniprot.org/uniprot/P0ADI0 charge swissprot:PINR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PINR_ECOLI eggNOG COG1961 http://eggnogapi.embl.de/nog_data/html/tree/COG1961 eggNOG ENOG4105MN3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105MN3 epestfind swissprot:PINR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PINR_ECOLI garnier swissprot:PINR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PINR_ECOLI helixturnhelix swissprot:PINR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PINR_ECOLI hmoment swissprot:PINR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PINR_ECOLI iep swissprot:PINR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PINR_ECOLI inforesidue swissprot:PINR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PINR_ECOLI octanol swissprot:PINR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PINR_ECOLI pepcoil swissprot:PINR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PINR_ECOLI pepdigest swissprot:PINR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PINR_ECOLI pepinfo swissprot:PINR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PINR_ECOLI pepnet swissprot:PINR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PINR_ECOLI pepstats swissprot:PINR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PINR_ECOLI pepwheel swissprot:PINR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PINR_ECOLI pepwindow swissprot:PINR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PINR_ECOLI sigcleave swissprot:PINR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PINR_ECOLI ## Database ID URL or Descriptions # BioGrid 4261694 10 # EcoGene EG13815 yneG # IntAct P76148 24 # InterPro IPR020378 DUF4186 # Organism YNEG_ECOLI Escherichia coli (strain K12) # PATRIC 32118344 VBIEscCol129921_1592 # PIR F64906 F64906 # Pfam PF13811 DUF4186 # ProDom PD076485 Uncharacterised_YneG # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNEG_ECOLI Uncharacterized protein YneG # RefSeq NP_416040 NC_000913.3 # RefSeq WP_001191027 NZ_LN832404.1 # eggNOG ENOG4105M0C Bacteria # eggNOG ENOG4111UPV LUCA BLAST swissprot:YNEG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNEG_ECOLI BioCyc ECOL316407:JW1516-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1516-MONOMER BioCyc EcoCyc:G6809-MONOMER http://biocyc.org/getid?id=EcoCyc:G6809-MONOMER DIP DIP-12756N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12756N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3576 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3576 EcoGene EG13815 http://www.ecogene.org/geneInfo.php?eg_id=EG13815 EnsemblBacteria AAC74596 http://www.ensemblgenomes.org/id/AAC74596 EnsemblBacteria AAC74596 http://www.ensemblgenomes.org/id/AAC74596 EnsemblBacteria BAE76461 http://www.ensemblgenomes.org/id/BAE76461 EnsemblBacteria BAE76461 http://www.ensemblgenomes.org/id/BAE76461 EnsemblBacteria BAE76461 http://www.ensemblgenomes.org/id/BAE76461 EnsemblBacteria b1523 http://www.ensemblgenomes.org/id/b1523 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946171 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946171 HOGENOM HOG000120751 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120751&db=HOGENOM6 InParanoid P76148 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76148 IntAct P76148 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76148* InterPro IPR020378 http://www.ebi.ac.uk/interpro/entry/IPR020378 KEGG_Gene ecj:JW1516 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1516 KEGG_Gene eco:b1523 http://www.genome.jp/dbget-bin/www_bget?eco:b1523 OMA PRNDGKQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PRNDGKQ PSORT swissprot:YNEG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNEG_ECOLI PSORT-B swissprot:YNEG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNEG_ECOLI PSORT2 swissprot:YNEG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNEG_ECOLI Pfam PF13811 http://pfam.xfam.org/family/PF13811 Phobius swissprot:YNEG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNEG_ECOLI ProteinModelPortal P76148 http://www.proteinmodelportal.org/query/uniprot/P76148 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416040 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416040 RefSeq WP_001191027 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001191027 STRING 511145.b1523 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1523&targetmode=cogs UniProtKB YNEG_ECOLI http://www.uniprot.org/uniprot/YNEG_ECOLI UniProtKB-AC P76148 http://www.uniprot.org/uniprot/P76148 charge swissprot:YNEG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNEG_ECOLI eggNOG ENOG4105M0C http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105M0C eggNOG ENOG4111UPV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111UPV epestfind swissprot:YNEG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNEG_ECOLI garnier swissprot:YNEG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNEG_ECOLI helixturnhelix swissprot:YNEG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNEG_ECOLI hmoment swissprot:YNEG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNEG_ECOLI iep swissprot:YNEG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNEG_ECOLI inforesidue swissprot:YNEG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNEG_ECOLI octanol swissprot:YNEG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNEG_ECOLI pepcoil swissprot:YNEG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNEG_ECOLI pepdigest swissprot:YNEG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNEG_ECOLI pepinfo swissprot:YNEG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNEG_ECOLI pepnet swissprot:YNEG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNEG_ECOLI pepstats swissprot:YNEG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNEG_ECOLI pepwheel swissprot:YNEG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNEG_ECOLI pepwindow swissprot:YNEG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNEG_ECOLI sigcleave swissprot:YNEG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNEG_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES AROB_ECOLI Kinetic parameters KM=0.6 uM for 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate (at pH 6.5) {ECO 0000269|PubMed 2514789}; KM=5.5 uM for 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate (at pH 8.5) {ECO 0000269|PubMed 2514789}; # BRENDA 4.2.3 2026 # BioGrid 4259296 37 # CATALYTIC ACTIVITY 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. {ECO:0000269|PubMed 2514789}. # COFACTOR AROB_ECOLI Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000269|PubMed 2514789}; Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 2514789}; Note=Binds 1 divalent metal cation per subunit. Displays higher activity with Co(2+), however, Zn(2+) may be the physiological metal cofactor. {ECO 0000269|PubMed 2514789}; # COFACTOR AROB_ECOLI Name=NAD(+); Xref=ChEBI CHEBI 57540; Evidence={ECO 0000269|PubMed 2514789}; # EcoGene EG10074 aroB # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_function GO:0003856 3-dehydroquinate synthase activity; IMP:CACAO. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_function GO:0070403 NAD+ binding; IDA:EcoCyc. # GO_process GO:0008652 cellular amino acid biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0009073 aromatic amino acid family biosynthetic process; TAS:EcoliWiki. # GO_process GO:0009423 chorismate biosynthetic process; IBA:GO_Central. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # HAMAP MF_00110 DHQ_synthase # INTERACTION AROB_ECOLI P68646 fixX; NbExp=2; IntAct=EBI-550843, EBI-1113234; # IntAct P07639 9 # InterPro IPR016037 DHQ_synth_AroB # InterPro IPR030960 DHQS/DOIS # InterPro IPR030963 DHQ_synth_fam # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis # Organism AROB_ECOLI Escherichia coli (strain K12) # PATHWAY Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate step 2/7. # PATRIC 32122210 VBIEscCol129921_3482 # PIR A24863 SYECQ # PIRSF PIRSF001455 DHQ_synth # Pfam PF01761 DHQ_synthase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AROB_ECOLI 3-dehydroquinate synthase # RefSeq NP_417848 NC_000913.3 # RefSeq WP_000439848 NZ_LN832404.1 # SIMILARITY Belongs to the dehydroquinate synthase family. {ECO 0000305}. # SUBCELLULAR LOCATION AROB_ECOLI Cytoplasm. # SUBUNIT AROB_ECOLI Monomer. # TIGRFAMs TIGR01357 aroB # UniPathway UPA00053 UER00085 # eggNOG COG0337 LUCA # eggNOG ENOG4105D49 Bacteria BLAST swissprot:AROB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AROB_ECOLI BioCyc ECOL316407:JW3352-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3352-MONOMER BioCyc EcoCyc:AROB-MONOMER http://biocyc.org/getid?id=EcoCyc:AROB-MONOMER BioCyc MetaCyc:AROB-MONOMER http://biocyc.org/getid?id=MetaCyc:AROB-MONOMER COG COG0337 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0337 DIP DIP-9150N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9150N DOI 10.1007/BF00290345 http://dx.doi.org/10.1007/BF00290345 DOI 10.1007/BF00330946 http://dx.doi.org/10.1007/BF00330946 DOI 10.1016/0014-5793(86)80501-4 http://dx.doi.org/10.1016/0014-5793(86)80501-4 DOI 10.1021/bi00445a009 http://dx.doi.org/10.1021/bi00445a009 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.3.4 {ECO:0000269|PubMed:2514789} http://www.genome.jp/dbget-bin/www_bget?EC:4.2.3.4 {ECO:0000269|PubMed:2514789} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X03867 http://www.ebi.ac.uk/ena/data/view/X03867 EMBL X15162 http://www.ebi.ac.uk/ena/data/view/X15162 EMBL Z19601 http://www.ebi.ac.uk/ena/data/view/Z19601 ENZYME 4.2.3.4 {ECO:0000269|PubMed:2514789} http://enzyme.expasy.org/EC/4.2.3.4 {ECO:0000269|PubMed:2514789} EchoBASE EB0072 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0072 EcoGene EG10074 http://www.ecogene.org/geneInfo.php?eg_id=EG10074 EnsemblBacteria AAC76414 http://www.ensemblgenomes.org/id/AAC76414 EnsemblBacteria AAC76414 http://www.ensemblgenomes.org/id/AAC76414 EnsemblBacteria BAE77902 http://www.ensemblgenomes.org/id/BAE77902 EnsemblBacteria BAE77902 http://www.ensemblgenomes.org/id/BAE77902 EnsemblBacteria BAE77902 http://www.ensemblgenomes.org/id/BAE77902 EnsemblBacteria b3389 http://www.ensemblgenomes.org/id/b3389 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003856 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003856 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0070403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070403 GO_process GO:0008652 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008652 GO_process GO:0009073 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009073 GO_process GO:0009423 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009423 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 947927 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947927 HAMAP MF_00110 http://hamap.expasy.org/unirule/MF_00110 HOGENOM HOG000007970 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000007970&db=HOGENOM6 InParanoid P07639 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P07639 IntAct P07639 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P07639* IntEnz 4.2.3.4 {ECO:0000269|PubMed:2514789} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.3.4 {ECO:0000269|PubMed:2514789} InterPro IPR016037 http://www.ebi.ac.uk/interpro/entry/IPR016037 InterPro IPR030960 http://www.ebi.ac.uk/interpro/entry/IPR030960 InterPro IPR030963 http://www.ebi.ac.uk/interpro/entry/IPR030963 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3352 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3352 KEGG_Gene eco:b3389 http://www.genome.jp/dbget-bin/www_bget?eco:b3389 KEGG_Orthology KO:K01735 http://www.genome.jp/dbget-bin/www_bget?KO:K01735 KEGG_Pathway ko00400 http://www.genome.jp/kegg-bin/show_pathway?ko00400 KEGG_Reaction rn:R03083 http://www.genome.jp/dbget-bin/www_bget?rn:R03083 MINT MINT-1261041 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1261041 OMA THLGYGN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=THLGYGN PSORT swissprot:AROB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AROB_ECOLI PSORT-B swissprot:AROB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AROB_ECOLI PSORT2 swissprot:AROB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AROB_ECOLI Pfam PF01761 http://pfam.xfam.org/family/PF01761 Phobius swissprot:AROB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AROB_ECOLI PhylomeDB P07639 http://phylomedb.org/?seqid=P07639 ProteinModelPortal P07639 http://www.proteinmodelportal.org/query/uniprot/P07639 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2514789 http://www.ncbi.nlm.nih.gov/pubmed/2514789 PubMed 2549371 http://www.ncbi.nlm.nih.gov/pubmed/2549371 PubMed 3009224 http://www.ncbi.nlm.nih.gov/pubmed/3009224 PubMed 7603433 http://www.ncbi.nlm.nih.gov/pubmed/7603433 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417848 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417848 RefSeq WP_000439848 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000439848 SMR P07639 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P07639 STRING 511145.b3389 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3389&targetmode=cogs STRING COG0337 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0337&targetmode=cogs TIGRFAMs TIGR01357 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01357 UniProtKB AROB_ECOLI http://www.uniprot.org/uniprot/AROB_ECOLI UniProtKB-AC P07639 http://www.uniprot.org/uniprot/P07639 charge swissprot:AROB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AROB_ECOLI eggNOG COG0337 http://eggnogapi.embl.de/nog_data/html/tree/COG0337 eggNOG ENOG4105D49 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D49 epestfind swissprot:AROB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AROB_ECOLI garnier swissprot:AROB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AROB_ECOLI helixturnhelix swissprot:AROB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AROB_ECOLI hmoment swissprot:AROB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AROB_ECOLI iep swissprot:AROB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AROB_ECOLI inforesidue swissprot:AROB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AROB_ECOLI octanol swissprot:AROB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AROB_ECOLI pepcoil swissprot:AROB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AROB_ECOLI pepdigest swissprot:AROB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AROB_ECOLI pepinfo swissprot:AROB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AROB_ECOLI pepnet swissprot:AROB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AROB_ECOLI pepstats swissprot:AROB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AROB_ECOLI pepwheel swissprot:AROB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AROB_ECOLI pepwindow swissprot:AROB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AROB_ECOLI sigcleave swissprot:AROB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AROB_ECOLI ## Database ID URL or Descriptions # BioGrid 4259220 10 # EcoGene EG13524 ygaV # FUNCTION YGAV_ECOLI Functions as transcription repressor. {ECO 0000305|PubMed 18245262}. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_function GO:0044212 transcription regulatory region DNA binding; IBA:GO_Central. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IMP:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # IntAct P77295 10 # InterPro IPR001845 HTH_ArsR_DNA-bd_dom # InterPro IPR011991 WHTH_DNA-bd_dom # Organism YGAV_ECOLI Escherichia coli (strain K12) # PATRIC 32120724 VBIEscCol129921_2759 # PDB 3CUO X-ray; 2.00 A; A/B/C/D=1-99 # PIR D65046 D65046 # PRINTS PR00778 HTHARSR # PROSITE PS50987 HTH_ARSR_2 # Pfam PF01022 HTH_5 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGAV_ECOLI Probable HTH-type transcriptional regulator YgaV # RefSeq NP_417153 NC_000913.3 # RefSeq WP_000137280 NZ_LN832404.1 # SIMILARITY Contains 1 HTH arsR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00340}. # SMART SM00418 HTH_ARSR # SUBUNIT Homodimer. {ECO 0000305}. # SUPFAM SSF46785 SSF46785 # eggNOG COG0640 LUCA # eggNOG ENOG41080HT Bacteria BLAST swissprot:YGAV_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGAV_ECOLI BioCyc ECOL316407:JW2642-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2642-MONOMER BioCyc EcoCyc:G7397-MONOMER http://biocyc.org/getid?id=EcoCyc:G7397-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AEM.02294-07 http://dx.doi.org/10.1128/AEM.02294-07 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3296 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3296 EcoGene EG13524 http://www.ecogene.org/geneInfo.php?eg_id=EG13524 EnsemblBacteria AAC75714 http://www.ensemblgenomes.org/id/AAC75714 EnsemblBacteria AAC75714 http://www.ensemblgenomes.org/id/AAC75714 EnsemblBacteria BAA16530 http://www.ensemblgenomes.org/id/BAA16530 EnsemblBacteria BAA16530 http://www.ensemblgenomes.org/id/BAA16530 EnsemblBacteria BAA16530 http://www.ensemblgenomes.org/id/BAA16530 EnsemblBacteria b2667 http://www.ensemblgenomes.org/id/b2667 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0044212 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044212 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 947136 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947136 HOGENOM HOG000144506 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000144506&db=HOGENOM6 InParanoid P77295 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77295 IntAct P77295 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77295* InterPro IPR001845 http://www.ebi.ac.uk/interpro/entry/IPR001845 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW2642 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2642 KEGG_Gene eco:b2667 http://www.genome.jp/dbget-bin/www_bget?eco:b2667 OMA GERCVSE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GERCVSE PDB 3CUO http://www.ebi.ac.uk/pdbe-srv/view/entry/3CUO PDBsum 3CUO http://www.ebi.ac.uk/pdbsum/3CUO PRINTS PR00778 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00778 PROSITE PS50987 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50987 PSORT swissprot:YGAV_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGAV_ECOLI PSORT-B swissprot:YGAV_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGAV_ECOLI PSORT2 swissprot:YGAV_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGAV_ECOLI Pfam PF01022 http://pfam.xfam.org/family/PF01022 Phobius swissprot:YGAV_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGAV_ECOLI PhylomeDB P77295 http://phylomedb.org/?seqid=P77295 ProteinModelPortal P77295 http://www.proteinmodelportal.org/query/uniprot/P77295 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18245262 http://www.ncbi.nlm.nih.gov/pubmed/18245262 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417153 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417153 RefSeq WP_000137280 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000137280 SMART SM00418 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00418 SMR P77295 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77295 STRING 511145.b2667 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2667&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB YGAV_ECOLI http://www.uniprot.org/uniprot/YGAV_ECOLI UniProtKB-AC P77295 http://www.uniprot.org/uniprot/P77295 charge swissprot:YGAV_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGAV_ECOLI eggNOG COG0640 http://eggnogapi.embl.de/nog_data/html/tree/COG0640 eggNOG ENOG41080HT http://eggnogapi.embl.de/nog_data/html/tree/ENOG41080HT epestfind swissprot:YGAV_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGAV_ECOLI garnier swissprot:YGAV_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGAV_ECOLI helixturnhelix swissprot:YGAV_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGAV_ECOLI hmoment swissprot:YGAV_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGAV_ECOLI iep swissprot:YGAV_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGAV_ECOLI inforesidue swissprot:YGAV_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGAV_ECOLI octanol swissprot:YGAV_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGAV_ECOLI pepcoil swissprot:YGAV_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGAV_ECOLI pepdigest swissprot:YGAV_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGAV_ECOLI pepinfo swissprot:YGAV_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGAV_ECOLI pepnet swissprot:YGAV_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGAV_ECOLI pepstats swissprot:YGAV_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGAV_ECOLI pepwheel swissprot:YGAV_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGAV_ECOLI pepwindow swissprot:YGAV_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGAV_ECOLI sigcleave swissprot:YGAV_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGAV_ECOLI ## Database ID URL or Descriptions # Organism YUAV_ECOLI Escherichia coli (strain K12) # RecName YUAV_ECOLI Uncharacterized protein YuaV # RefSeq NP_061415 NC_002483.1 # RefSeq WP_010892533 NC_002483.1 BLAST swissprot:YUAV_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YUAV_ECOLI EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1263500 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263500 OMA WITVAPL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WITVAPL PSORT swissprot:YUAV_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YUAV_ECOLI PSORT-B swissprot:YUAV_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YUAV_ECOLI PSORT2 swissprot:YUAV_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YUAV_ECOLI Phobius swissprot:YUAV_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YUAV_ECOLI ProteinModelPortal Q9JMR9 http://www.proteinmodelportal.org/query/uniprot/Q9JMR9 RefSeq NP_061415 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061415 RefSeq WP_010892533 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_010892533 UniProtKB YUAV_ECOLI http://www.uniprot.org/uniprot/YUAV_ECOLI UniProtKB-AC Q9JMR9 http://www.uniprot.org/uniprot/Q9JMR9 charge swissprot:YUAV_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YUAV_ECOLI epestfind swissprot:YUAV_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YUAV_ECOLI garnier swissprot:YUAV_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YUAV_ECOLI helixturnhelix swissprot:YUAV_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YUAV_ECOLI hmoment swissprot:YUAV_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YUAV_ECOLI iep swissprot:YUAV_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YUAV_ECOLI inforesidue swissprot:YUAV_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YUAV_ECOLI octanol swissprot:YUAV_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YUAV_ECOLI pepcoil swissprot:YUAV_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YUAV_ECOLI pepdigest swissprot:YUAV_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YUAV_ECOLI pepinfo swissprot:YUAV_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YUAV_ECOLI pepnet swissprot:YUAV_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YUAV_ECOLI pepstats swissprot:YUAV_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YUAV_ECOLI pepwheel swissprot:YUAV_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YUAV_ECOLI pepwindow swissprot:YUAV_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YUAV_ECOLI sigcleave swissprot:YUAV_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YUAV_ECOLI ## Database ID URL or Descriptions # AltName Alpha,alpha-trehalase {ECO:0000255|HAMAP-Rule MF_01059} # AltName Alpha,alpha-trehalose glucohydrolase {ECO:0000255|HAMAP-Rule MF_01059} # BIOPHYSICOCHEMICAL PROPERTIES pH dependence Optimum pH is 6.0.; # BioGrid 4260775 12 # CATALYTIC ACTIVITY Alpha,alpha-trehalose + H(2)O = beta-D-glucose + alpha-D-glucose. {ECO:0000255|HAMAP-Rule MF_01059}. # ENZYME REGULATION TREF_ECOLI Activity decreases with increasing salt concentrations. # EcoGene EG12245 treF # FUNCTION TREF_ECOLI Hydrolyzes trehalose to glucose. Could be involved, in cells returning to low osmolarity conditions, in the utilization of the accumulated cytoplasmic trehalose, which was synthesized in response to high osmolarity. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0004555 alpha,alpha-trehalase activity; IDA:EcoCyc. # GO_process GO:0005993 trehalose catabolic process; IMP:EcoCyc. # GO_process GO:0071474 cellular hyperosmotic response; IEP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009056 catabolic process # HAMAP MF_01059 Cyt_trehalase # INDUCTION TREF_ECOLI Weakly induced by high osmolarity but not by trehalose. Expression is partially dependent on RpoS. # IntAct P62601 2 # InterPro IPR001661 Glyco_hydro_37 # InterPro IPR008928 6-hairpin_glycosidase-like # InterPro IPR018232 Glyco_hydro_37_CS # InterPro IPR023715 Cyt_trehalase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00500 Starch and sucrose metabolism # Organism TREF_ECOLI Escherichia coli (strain K12) # PANTHER PTHR23403 PTHR23403 # PATHWAY Glycan degradation; trehalose degradation; D-glucose from alpha,alpha-trehalose: step 1/1. {ECO 0000255|HAMAP- Rule:MF_01059}. # PATRIC 32122500 VBIEscCol129921_3628 # PIR S47739 S47739 # PRINTS PR00744 GLHYDRLASE37 # PROSITE PS00927 TREHALASE_1 # PROSITE PS00928 TREHALASE_2 # Pfam PF01204 Trehalase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Cytoplasmic trehalase {ECO:0000255|HAMAP-Rule MF_01059} # RefSeq NP_417976 NC_000913.3 # RefSeq WP_000934216 NZ_LN832404.1 # SIMILARITY Belongs to the glycosyl hydrolase 37 family. {ECO:0000255|HAMAP-Rule MF_01059}. # SUBCELLULAR LOCATION TREF_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_01059, ECO 0000269|PubMed 10816581}. # SUBUNIT Monomer. {ECO 0000305}. # SUPFAM SSF48208 SSF48208 # UniPathway UPA00300 UER00535 # eggNOG COG1626 LUCA # eggNOG ENOG4105E53 Bacteria BLAST swissprot:TREF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TREF_ECOLI BioCyc ECOL316407:JW3487-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3487-MONOMER BioCyc EcoCyc:TREHALACYTO-MONOMER http://biocyc.org/getid?id=EcoCyc:TREHALACYTO-MONOMER BioCyc MetaCyc:TREHALACYTO-MONOMER http://biocyc.org/getid?id=MetaCyc:TREHALACYTO-MONOMER COG COG1626 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1626 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M002793200 http://dx.doi.org/10.1074/jbc.M002793200 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.2.1.28 {ECO:0000255|HAMAP-Rule:MF_01059} http://www.genome.jp/dbget-bin/www_bget?EC:3.2.1.28 {ECO:0000255|HAMAP-Rule:MF_01059} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.2.1.28 {ECO:0000255|HAMAP-Rule:MF_01059} http://enzyme.expasy.org/EC/3.2.1.28 {ECO:0000255|HAMAP-Rule:MF_01059} EchoBASE EB2156 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2156 EcoGene EG12245 http://www.ecogene.org/geneInfo.php?eg_id=EG12245 EnsemblBacteria AAC76544 http://www.ensemblgenomes.org/id/AAC76544 EnsemblBacteria AAC76544 http://www.ensemblgenomes.org/id/AAC76544 EnsemblBacteria BAE77775 http://www.ensemblgenomes.org/id/BAE77775 EnsemblBacteria BAE77775 http://www.ensemblgenomes.org/id/BAE77775 EnsemblBacteria BAE77775 http://www.ensemblgenomes.org/id/BAE77775 EnsemblBacteria b3519 http://www.ensemblgenomes.org/id/b3519 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004555 GO_process GO:0005993 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005993 GO_process GO:0071474 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071474 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GeneID 948037 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948037 HAMAP MF_01059 http://hamap.expasy.org/unirule/MF_01059 HOGENOM HOG000215464 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000215464&db=HOGENOM6 InParanoid P62601 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P62601 IntAct P62601 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P62601* IntEnz 3.2.1.28 {ECO:0000255|HAMAP-Rule:MF_01059} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.2.1.28 {ECO:0000255|HAMAP-Rule:MF_01059} InterPro IPR001661 http://www.ebi.ac.uk/interpro/entry/IPR001661 InterPro IPR008928 http://www.ebi.ac.uk/interpro/entry/IPR008928 InterPro IPR018232 http://www.ebi.ac.uk/interpro/entry/IPR018232 InterPro IPR023715 http://www.ebi.ac.uk/interpro/entry/IPR023715 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3487 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3487 KEGG_Gene eco:b3519 http://www.genome.jp/dbget-bin/www_bget?eco:b3519 KEGG_Orthology KO:K01194 http://www.genome.jp/dbget-bin/www_bget?KO:K01194 KEGG_Pathway ko00500 http://www.genome.jp/kegg-bin/show_pathway?ko00500 KEGG_Reaction rn:R00010 http://www.genome.jp/dbget-bin/www_bget?rn:R00010 OMA FWMDGAD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FWMDGAD PANTHER PTHR23403 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23403 PRINTS PR00744 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00744 PROSITE PS00927 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00927 PROSITE PS00928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00928 PSORT swissprot:TREF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TREF_ECOLI PSORT-B swissprot:TREF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TREF_ECOLI PSORT2 swissprot:TREF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TREF_ECOLI Pfam PF01204 http://pfam.xfam.org/family/PF01204 Phobius swissprot:TREF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TREF_ECOLI PhylomeDB P62601 http://phylomedb.org/?seqid=P62601 ProteinModelPortal P62601 http://www.proteinmodelportal.org/query/uniprot/P62601 PubMed 10816581 http://www.ncbi.nlm.nih.gov/pubmed/10816581 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 8892826 http://www.ncbi.nlm.nih.gov/pubmed/8892826 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417976 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417976 RefSeq WP_000934216 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000934216 SMR P62601 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P62601 STRING 511145.b3519 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3519&targetmode=cogs STRING COG1626 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1626&targetmode=cogs SUPFAM SSF48208 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48208 UniProtKB TREF_ECOLI http://www.uniprot.org/uniprot/TREF_ECOLI UniProtKB-AC P62601 http://www.uniprot.org/uniprot/P62601 charge swissprot:TREF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TREF_ECOLI eggNOG COG1626 http://eggnogapi.embl.de/nog_data/html/tree/COG1626 eggNOG ENOG4105E53 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E53 epestfind swissprot:TREF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TREF_ECOLI garnier swissprot:TREF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TREF_ECOLI helixturnhelix swissprot:TREF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TREF_ECOLI hmoment swissprot:TREF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TREF_ECOLI iep swissprot:TREF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TREF_ECOLI inforesidue swissprot:TREF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TREF_ECOLI octanol swissprot:TREF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TREF_ECOLI pepcoil swissprot:TREF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TREF_ECOLI pepdigest swissprot:TREF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TREF_ECOLI pepinfo swissprot:TREF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TREF_ECOLI pepnet swissprot:TREF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TREF_ECOLI pepstats swissprot:TREF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TREF_ECOLI pepwheel swissprot:TREF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TREF_ECOLI pepwindow swissprot:TREF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TREF_ECOLI sigcleave swissprot:TREF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TREF_ECOLI ## Database ID URL or Descriptions # AltName MALE_ECOLI MBP # AltName MALE_ECOLI MMBP # AltName MALE_ECOLI Maltodextrin-binding protein # BioGrid 4263065 9 # EcoGene EG10554 malE # FUNCTION MALE_ECOLI Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_component GO:0042597 periplasmic space; IDA:EcoliWiki. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IGI:EcoliWiki. # GO_component GO:0055052 ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing; IDA:EcoCyc. # GO_component GO:1990060 maltose transport complex; IDA:EcoCyc. # GO_function GO:0005215 transporter activity; IGI:EcoliWiki. # GO_function GO:0005363 maltose transmembrane transporter activity; IEA:InterPro. # GO_function GO:1901982 maltose binding; IDA:EcoCyc. # GO_process GO:0006810 transport; IGI:EcoliWiki. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0008643 carbohydrate transport; IGI:EcoliWiki. # GO_process GO:0015768 maltose transport; IDA:EcoCyc. # GO_process GO:0034289 detection of maltose stimulus; IMP:EcoCyc. # GO_process GO:0042956 maltodextrin transport; IMP:EcoCyc. # GO_process GO:0060326 cell chemotaxis; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0048870 cell motility # INDUCTION Permanently repressed by cold shock in a PNPase- dependent fashion. {ECO:0000269|PubMed 14527658}. # INTERACTION MALE_ECOLI P0A6F5 groL; NbExp=3; IntAct=EBI-369910, EBI-543750; P02916 malF; NbExp=2; IntAct=EBI-369910, EBI-1118919; # IntAct P0AEX9 10 # InterPro IPR006060 Maltose-bd # InterPro IPR006061 SBP_1_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00194 Maltose/maltodextrin transport system # KEGG_Brite ko02000 M00197 Putative fructooligosaccharide transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # KEGG_Pathway ko02030 Bacterial chemotaxis # Organism MALE_ECOLI Escherichia coli (strain K12) # PATRIC 32123601 VBIEscCol129921_4149 # PDB 1A7L X-ray; 2.90 A; A/B/C=27-389 # PDB 1ANF X-ray; 1.67 A; A=27-396 # PDB 1DMB X-ray; 1.80 A; A=27-396 # PDB 1EZ9 X-ray; 1.90 A; A/B=27-396 # PDB 1EZO NMR; -; A=29-396 # PDB 1EZP NMR; -; A=29-396 # PDB 1FQA X-ray; 1.90 A; A=28-396 # PDB 1FQB X-ray; 1.90 A; A=28-396 # PDB 1FQC X-ray; 2.30 A; A=28-396 # PDB 1FQD X-ray; 2.30 A; A=28-396 # PDB 1HSJ X-ray; 2.30 A; A/B=27-396 # PDB 1IUD X-ray; 2.70 A; A=27-396 # PDB 1JVX X-ray; 2.50 A; A=27-396 # PDB 1JVY X-ray; 1.90 A; A=27-396 # PDB 1JW4 X-ray; 2.00 A; A=27-396 # PDB 1JW5 X-ray; 2.00 A; A=27-396 # PDB 1LAX X-ray; 1.85 A; A/C=27-396 # PDB 1LLS X-ray; 1.80 A; A=27-396 # PDB 1MDP X-ray; 2.30 A; 1/2=27-396 # PDB 1MDQ X-ray; 1.90 A; A=27-396 # PDB 1MG1 X-ray; 2.50 A; A=31-392 # PDB 1MH3 X-ray; 2.10 A; A=27-392 # PDB 1MH4 X-ray; 2.30 A; A=27-392 # PDB 1MPB X-ray; 2.00 A; A=27-396 # PDB 1MPC X-ray; 2.10 A; A=27-396 # PDB 1MPD X-ray; 2.30 A; A=27-396 # PDB 1N3W X-ray; 2.60 A; A=27-396 # PDB 1N3X X-ray; 2.50 A; A=27-396 # PDB 1NL5 X-ray; 2.10 A; A=27-396 # PDB 1NMU X-ray; 2.31 A; A/C=27-392 # PDB 1OMP X-ray; 1.80 A; A=27-396 # PDB 1PEB X-ray; 2.60 A; A=27-396 # PDB 1R6Z X-ray; 2.80 A; A/P/Z=27-392 # PDB 1SVX X-ray; 2.24 A; B=29-392 # PDB 1T0K X-ray; 3.24 A; A=29-392 # PDB 1Y4C X-ray; 1.90 A; A=27-392 # PDB 1YTV X-ray; 1.80 A; A/B=27-392 # PDB 1ZIU X-ray; 2.00 A; A=27-396 # PDB 1ZJL X-ray; 2.00 A; A=27-396 # PDB 1ZKB X-ray; 2.20 A; A=27-396 # PDB 1ZMG X-ray; 2.50 A; A=27-396 # PDB 2D21 NMR; -; A=27-396 # PDB 2H25 NMR; -; A=27-396 # PDB 2KLF NMR; -; A=27-396 # PDB 2MV0 NMR; -; A=27-396 # PDB 2N44 NMR; -; A=27-396 # PDB 2N45 NMR; -; A=27-396 # PDB 2NVU X-ray; 2.80 A; B=25-392 # PDB 2OBG X-ray; 2.35 A; A=31-396 # PDB 2OK2 X-ray; 2.00 A; A/B=28-392 # PDB 2R6G X-ray; 2.80 A; E=27-396 # PDB 2V93 NMR; -; A=27-396 # PDB 2VGQ X-ray; 2.10 A; A=27-392 # PDB 2XZ3 X-ray; 1.95 A; A=27-392 # PDB 2ZXT X-ray; 3.00 A; A=27-392 # PDB 3A3C X-ray; 2.50 A; A=29-392 # PDB 3C4M X-ray; 1.95 A; A/B=26-392 # PDB 3CSB X-ray; 2.00 A; A=31-396 # PDB 3CSG X-ray; 1.80 A; A=31-396 # PDB 3D4C X-ray; 2.90 A; A=27-393 # PDB 3DM0 X-ray; 2.40 A; A=27-387 # PDB 3EHS X-ray; 2.76 A; A=26-392 # PDB 3EHT X-ray; 3.40 A; A=26-392 # PDB 3EHU X-ray; 1.96 A; A/B=26-392 # PDB 3F5F X-ray; 2.65 A; A=27-387 # PDB 3G7V X-ray; 1.86 A; A/B/C/D=27-392 # PDB 3G7W X-ray; 1.75 A; A=27-392 # PDB 3H3G X-ray; 1.94 A; A=26-392 # PDB 3H4Z X-ray; 2.35 A; A/B/C=27-392 # PDB 3HPI X-ray; 2.00 A; A/B=27-396 # PDB 3HST X-ray; 2.25 A; A/C=27-392 # PDB 3IO4 X-ray; 3.63 A; A/B/C=27-384 # PDB 3IO6 X-ray; 3.70 A; A/B/C=27-384 # PDB 3IOR X-ray; 3.60 A; A/B/C=27-384 # PDB 3IOT X-ray; 3.50 A; A/B/C=27-384 # PDB 3IOU X-ray; 3.70 A; A/B/C=27-384 # PDB 3IOV X-ray; 3.70 A; A/B/C=27-384 # PDB 3IOW X-ray; 3.50 A; A/B/C=27-384 # PDB 3J9P EM; 4.24 A; A/B/C/D=27-392 # PDB 3KJT X-ray; 1.50 A; A=27-396 # PDB 3L2J X-ray; 3.24 A; A/B=29-392 # PDB 3LBS X-ray; 2.15 A; A/B=29-390 # PDB 3LC8 X-ray; 2.00 A; A/B=29-390 # PDB 3MBP X-ray; 1.70 A; A=27-396 # PDB 3MP1 X-ray; 2.60 A; A=27-387 # PDB 3MP6 X-ray; 1.48 A; A=27-387 # PDB 3MP8 X-ray; 1.92 A; A=27-387 # PDB 3MQ9 X-ray; 2.80 A; A/B/C/D/E/F/G/H=27-395 # PDB 3N94 X-ray; 1.80 A; A=26-392 # PDB 3O3U X-ray; 1.50 A; N=28-384 # PDB 3OAI X-ray; 2.10 A; A/B=27-392 # PDB 3OSQ X-ray; 1.90 A; A=27-396 # PDB 3OSR X-ray; 2.00 A; A/B=27-396 # PDB 3PGF X-ray; 2.10 A; A=27-393 # PDB 3PUV X-ray; 2.40 A; E=27-396 # PDB 3PUW X-ray; 2.30 A; E=27-396 # PDB 3PUX X-ray; 2.30 A; E=27-396 # PDB 3PUY X-ray; 3.10 A; E=27-396 # PDB 3PUZ X-ray; 2.90 A; E=27-396 # PDB 3PV0 X-ray; 3.10 A; E=27-396 # PDB 3PY7 X-ray; 2.29 A; A=27-392 # PDB 3Q25 X-ray; 1.90 A; A=27-392 # PDB 3Q26 X-ray; 1.54 A; A=27-392 # PDB 3Q27 X-ray; 1.30 A; A=27-392 # PDB 3Q28 X-ray; 1.60 A; A=27-392 # PDB 3Q29 X-ray; 2.30 A; A/C=27-392 # PDB 3RLF X-ray; 2.20 A; E=27-396 # PDB 3RUM X-ray; 1.85 A; A=27-392 # PDB 3SER X-ray; 2.35 A; A/C=27-384 # PDB 3SES X-ray; 1.90 A; A/C=27-384 # PDB 3SET X-ray; 1.90 A; A/C=27-384 # PDB 3SEU X-ray; 1.85 A; A=27-384 # PDB 3SEV X-ray; 3.05 A; A/C/E=27-384 # PDB 3SEW X-ray; 1.55 A; A=27-384 # PDB 3SEX X-ray; 1.95 A; A/C=27-384 # PDB 3SEY X-ray; 1.85 A; A/C/E=27-384 # PDB 3VFJ X-ray; 2.05 A; A=27-392 # PDB 3W15 X-ray; 1.80 A; C=27-396 # PDB 3WAI X-ray; 1.90 A; A=27-392 # PDB 3WOA X-ray; 2.00 A; A=27-393 # PDB 4B3N X-ray; 3.30 A; A/B=27-395 # PDB 4BL8 X-ray; 3.04 A; A/B=27-393 # PDB 4BL9 X-ray; 2.80 A; A/B/C/D=27-393 # PDB 4BLA X-ray; 3.50 A; A/B/C/D=27-393 # PDB 4BLB X-ray; 2.80 A; A/B/C/D=27-393 # PDB 4BLD X-ray; 2.80 A; A/B/C/D=27-393 # PDB 4DXB X-ray; 2.29 A; A/B=27-396 # PDB 4DXC X-ray; 2.30 A; A=27-396 # PDB 4EDQ X-ray; 1.64 A; A/B=27-384 # PDB 4EGC X-ray; 1.99 A; A=27-392 # PDB 4EXK X-ray; 1.28 A; A=26-392 # PDB 4FE8 X-ray; 3.00 A; A/B/C=27-384 # PDB 4FEB X-ray; 2.80 A; A/B/C=27-384 # PDB 4FEC X-ray; 3.00 A; A/B/C=27-384 # PDB 4FED X-ray; 2.81 A; A/B/C=27-384 # PDB 4GIZ X-ray; 2.55 A; A/B=27-392 # PDB 4GLI X-ray; 1.90 A; A=27-395 # PDB 4IFP X-ray; 1.99 A; A/B/C=27-384 # PDB 4IKM X-ray; 2.46 A; A=27-392 # PDB 4IRL X-ray; 1.47 A; A/B/C=27-384 # PDB 4JBZ X-ray; 2.40 A; A/B/C=27-392 # PDB 4JKM X-ray; 2.26 A; C/D=27-392 # PDB 4KEG X-ray; 2.50 A; A=27-387 # PDB 4KHZ X-ray; 2.90 A; E=27-396 # PDB 4KI0 X-ray; 2.38 A; E=27-396 # PDB 4KV3 X-ray; 2.20 A; A/B=27-392 # PDB 4KYC X-ray; 1.95 A; A=27-392 # PDB 4KYD X-ray; 2.21 A; A/B=27-392 # PDB 4KYE X-ray; 2.60 A; A=27-392 # PDB 4LOG X-ray; 2.70 A; A/B=26-392 # PDB 4MBP X-ray; 1.70 A; A=27-396 # PDB 4N4X X-ray; 2.50 A; A=27-387 # PDB 4NDZ X-ray; 3.45 A; A/B/C/D/E/F=27-393 # PDB 4O2X X-ray; 2.70 A; A/B=27-396 # PDB 4OGM X-ray; 2.23 A; A=27-387 # PDB 4PE2 X-ray; 1.72 A; A=27-392 # PDB 4QSZ X-ray; 2.86 A; A/B=27-387 # PDB 4QVH X-ray; 1.75 A; A/B=27-392 # PDB 4R0Y X-ray; 2.00 A; A/B=27-387 # PDB 4RG5 X-ray; 1.70 A; A/B=27-395 # PDB 4RWF X-ray; 1.76 A; A=26-392 # PDB 4RWG X-ray; 2.44 A; A/B/C=26-392 # PDB 4TSM X-ray; 1.90 A; A/B/C=27-392 # PDB 4WJV X-ray; 3.20 A; E/F/G/H=27-393 # PDB 4WMS X-ray; 1.90 A; A=27-392 # PDB 4WMT X-ray; 2.35 A; A=27-392 # PDB 4WMU X-ray; 1.55 A; A=27-392 # PDB 4WMV X-ray; 2.40 A; A=27-392 # PDB 4WMW X-ray; 1.90 A; A=27-392 # PDB 4WMX X-ray; 2.00 A; A=27-392 # PDB 4WRN X-ray; 3.20 A; A/B=27-393 # PDB 4WTH X-ray; 2.25 A; A/B=27-392 # PDB 4WVH X-ray; 2.10 A; A=33-392 # PDB 4XA2 X-ray; 1.98 A; A/B=27-392 # PDB 4XHS X-ray; 1.70 A; A/B=27-392 # PDB 4XR8 X-ray; 2.25 A; A/B=27-392 # PDB 4XZS X-ray; 2.12 A; A/B=27-392 # PDB 4XZV X-ray; 3.58 A; A/C/E/G=27-392 # PDB 5AQ9 X-ray; 1.86 A; B/D=33-392 # PDB 5AZ6 X-ray; 2.56 A; A/B=27-394 # PDB 5AZ7 X-ray; 1.96 A; A=27-394 # PDB 5AZ8 X-ray; 1.70 A; A=27-394 # PDB 5AZ9 X-ray; 1.82 A; A=27-394 # PDB 5AZA X-ray; 2.08 A; A=27-394 # PDB 5C7R X-ray; 1.94 A; A/B=27-384 # PDB 5CBN X-ray; 2.30 A; B=27-392 # PDB 5CFV X-ray; 1.80 A; A=27-392 # PDB 5DFM X-ray; 2.30 A; A/B=27-384 # PDB 5DIS X-ray; 2.85 A; D=32-387 # PDB 5E24 X-ray; 2.14 A; A/C=27-396 # PDB 5EDU X-ray; 2.79 A; A/B=27-392 # PDB 5FSG X-ray; 3.21 A; A=27-384 # PDB 5GRU X-ray; 1.96 A; A=27-392 # PDB 5GS2 X-ray; 3.59 A; A=27-393 # PDB 5HZ7 X-ray; 1.43 A; A=27-392 # PDB 5I69 X-ray; 2.70 A; A=27-392 # PDB 5IHJ X-ray; 2.20 A; A=27-392 # PDB 5IQZ X-ray; 2.33 A; A=27-392 # PDB 5JJ4 X-ray; 2.81 A; A/B/C=27-393 # PDB 5JTQ NMR; -; E/F=108-149 # PDB 5JTR NMR; -; E/F/G/H=168-207 # PDB 5LDF EM; 6.20 A; M/N/O/P/Q/R/S/T/U/V/W/X=27-396 # PIR A03428 JGECM # PRINTS PR00181 MALTOSEBP # PROSITE PS01037 SBP_BACTERIAL_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MALE_ECOLI Maltose-binding periplasmic protein # RefSeq NP_418458 NC_000913.3 # RefSeq WP_000695387 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial solute-binding protein 1 family. {ECO 0000305}. # SUBCELLULAR LOCATION MALE_ECOLI Periplasm. # TCDB 3.A.1.1 the atp-binding cassette (abc) superfamily # eggNOG COG2182 LUCA # eggNOG ENOG4107FKK Bacteria BLAST swissprot:MALE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MALE_ECOLI BioCyc ECOL316407:JW3994-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3994-MONOMER BioCyc EcoCyc:MALE-MONOMER http://biocyc.org/getid?id=EcoCyc:MALE-MONOMER BioCyc MetaCyc:MALE-MONOMER http://biocyc.org/getid?id=MetaCyc:MALE-MONOMER COG COG2182 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2182 DIP DIP-31871N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31871N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1998.1726 http://dx.doi.org/10.1006/jmbi.1998.1726 DOI 10.1007/BF00333794 http://dx.doi.org/10.1007/BF00333794 DOI 10.1016/0022-2836(82)90405-3 http://dx.doi.org/10.1016/0022-2836(82)90405-3 DOI 10.1016/S0923-2508(03)00167-0 http://dx.doi.org/10.1016/S0923-2508(03)00167-0 DOI 10.1016/S0969-2126(97)00253-0 http://dx.doi.org/10.1016/S0969-2126(97)00253-0 DOI 10.1021/bi00159a003 http://dx.doi.org/10.1021/bi00159a003 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0806975105 http://dx.doi.org/10.1073/pnas.0806975105 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01648 http://www.ebi.ac.uk/ena/data/view/J01648 EMBL M12635 http://www.ebi.ac.uk/ena/data/view/M12635 EMBL M12647 http://www.ebi.ac.uk/ena/data/view/M12647 EMBL M12650 http://www.ebi.ac.uk/ena/data/view/M12650 EMBL M12653 http://www.ebi.ac.uk/ena/data/view/M12653 EMBL M16181 http://www.ebi.ac.uk/ena/data/view/M16181 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00303 http://www.ebi.ac.uk/ena/data/view/V00303 EchoBASE EB0549 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0549 EcoGene EG10554 http://www.ecogene.org/geneInfo.php?eg_id=EG10554 EnsemblBacteria AAC77004 http://www.ensemblgenomes.org/id/AAC77004 EnsemblBacteria AAC77004 http://www.ensemblgenomes.org/id/AAC77004 EnsemblBacteria BAE78036 http://www.ensemblgenomes.org/id/BAE78036 EnsemblBacteria BAE78036 http://www.ensemblgenomes.org/id/BAE78036 EnsemblBacteria BAE78036 http://www.ensemblgenomes.org/id/BAE78036 EnsemblBacteria b4034 http://www.ensemblgenomes.org/id/b4034 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_component GO:0055052 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055052 GO_component GO:1990060 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990060 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_function GO:0005363 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005363 GO_function GO:1901982 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901982 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0008643 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008643 GO_process GO:0015768 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015768 GO_process GO:0034289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034289 GO_process GO:0042956 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042956 GO_process GO:0060326 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060326 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 GeneID 948538 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948538 HOGENOM HOG000055250 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000055250&db=HOGENOM6 InParanoid P0AEX9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEX9 IntAct P0AEX9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEX9* InterPro IPR006060 http://www.ebi.ac.uk/interpro/entry/IPR006060 InterPro IPR006061 http://www.ebi.ac.uk/interpro/entry/IPR006061 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3994 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3994 KEGG_Gene eco:b4034 http://www.genome.jp/dbget-bin/www_bget?eco:b4034 KEGG_Orthology KO:K10108 http://www.genome.jp/dbget-bin/www_bget?KO:K10108 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 KEGG_Pathway ko02030 http://www.genome.jp/kegg-bin/show_pathway?ko02030 OMA WAWANID http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WAWANID PDB 1A7L http://www.ebi.ac.uk/pdbe-srv/view/entry/1A7L PDB 1ANF http://www.ebi.ac.uk/pdbe-srv/view/entry/1ANF PDB 1DMB http://www.ebi.ac.uk/pdbe-srv/view/entry/1DMB PDB 1EZ9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1EZ9 PDB 1EZO http://www.ebi.ac.uk/pdbe-srv/view/entry/1EZO PDB 1EZP http://www.ebi.ac.uk/pdbe-srv/view/entry/1EZP PDB 1FQA http://www.ebi.ac.uk/pdbe-srv/view/entry/1FQA PDB 1FQB http://www.ebi.ac.uk/pdbe-srv/view/entry/1FQB PDB 1FQC http://www.ebi.ac.uk/pdbe-srv/view/entry/1FQC PDB 1FQD http://www.ebi.ac.uk/pdbe-srv/view/entry/1FQD PDB 1HSJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1HSJ PDB 1IUD http://www.ebi.ac.uk/pdbe-srv/view/entry/1IUD PDB 1JVX http://www.ebi.ac.uk/pdbe-srv/view/entry/1JVX PDB 1JVY http://www.ebi.ac.uk/pdbe-srv/view/entry/1JVY PDB 1JW4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1JW4 PDB 1JW5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1JW5 PDB 1LAX http://www.ebi.ac.uk/pdbe-srv/view/entry/1LAX PDB 1LLS http://www.ebi.ac.uk/pdbe-srv/view/entry/1LLS PDB 1MDP http://www.ebi.ac.uk/pdbe-srv/view/entry/1MDP PDB 1MDQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1MDQ PDB 1MG1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1MG1 PDB 1MH3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1MH3 PDB 1MH4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1MH4 PDB 1MPB http://www.ebi.ac.uk/pdbe-srv/view/entry/1MPB PDB 1MPC http://www.ebi.ac.uk/pdbe-srv/view/entry/1MPC PDB 1MPD http://www.ebi.ac.uk/pdbe-srv/view/entry/1MPD PDB 1N3W http://www.ebi.ac.uk/pdbe-srv/view/entry/1N3W PDB 1N3X http://www.ebi.ac.uk/pdbe-srv/view/entry/1N3X PDB 1NL5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1NL5 PDB 1NMU http://www.ebi.ac.uk/pdbe-srv/view/entry/1NMU PDB 1OMP http://www.ebi.ac.uk/pdbe-srv/view/entry/1OMP PDB 1PEB http://www.ebi.ac.uk/pdbe-srv/view/entry/1PEB PDB 1R6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/1R6Z PDB 1SVX http://www.ebi.ac.uk/pdbe-srv/view/entry/1SVX PDB 1T0K http://www.ebi.ac.uk/pdbe-srv/view/entry/1T0K PDB 1Y4C http://www.ebi.ac.uk/pdbe-srv/view/entry/1Y4C PDB 1YTV http://www.ebi.ac.uk/pdbe-srv/view/entry/1YTV PDB 1ZIU http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZIU PDB 1ZJL http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZJL PDB 1ZKB http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZKB PDB 1ZMG http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZMG PDB 2D21 http://www.ebi.ac.uk/pdbe-srv/view/entry/2D21 PDB 2H25 http://www.ebi.ac.uk/pdbe-srv/view/entry/2H25 PDB 2KLF http://www.ebi.ac.uk/pdbe-srv/view/entry/2KLF PDB 2MV0 http://www.ebi.ac.uk/pdbe-srv/view/entry/2MV0 PDB 2N44 http://www.ebi.ac.uk/pdbe-srv/view/entry/2N44 PDB 2N45 http://www.ebi.ac.uk/pdbe-srv/view/entry/2N45 PDB 2NVU http://www.ebi.ac.uk/pdbe-srv/view/entry/2NVU PDB 2OBG http://www.ebi.ac.uk/pdbe-srv/view/entry/2OBG PDB 2OK2 http://www.ebi.ac.uk/pdbe-srv/view/entry/2OK2 PDB 2R6G http://www.ebi.ac.uk/pdbe-srv/view/entry/2R6G PDB 2V93 http://www.ebi.ac.uk/pdbe-srv/view/entry/2V93 PDB 2VGQ http://www.ebi.ac.uk/pdbe-srv/view/entry/2VGQ PDB 2XZ3 http://www.ebi.ac.uk/pdbe-srv/view/entry/2XZ3 PDB 2ZXT http://www.ebi.ac.uk/pdbe-srv/view/entry/2ZXT PDB 3A3C http://www.ebi.ac.uk/pdbe-srv/view/entry/3A3C PDB 3C4M http://www.ebi.ac.uk/pdbe-srv/view/entry/3C4M PDB 3CSB http://www.ebi.ac.uk/pdbe-srv/view/entry/3CSB PDB 3CSG http://www.ebi.ac.uk/pdbe-srv/view/entry/3CSG PDB 3D4C http://www.ebi.ac.uk/pdbe-srv/view/entry/3D4C PDB 3DM0 http://www.ebi.ac.uk/pdbe-srv/view/entry/3DM0 PDB 3EHS http://www.ebi.ac.uk/pdbe-srv/view/entry/3EHS PDB 3EHT http://www.ebi.ac.uk/pdbe-srv/view/entry/3EHT PDB 3EHU http://www.ebi.ac.uk/pdbe-srv/view/entry/3EHU PDB 3F5F http://www.ebi.ac.uk/pdbe-srv/view/entry/3F5F PDB 3G7V http://www.ebi.ac.uk/pdbe-srv/view/entry/3G7V PDB 3G7W http://www.ebi.ac.uk/pdbe-srv/view/entry/3G7W PDB 3H3G http://www.ebi.ac.uk/pdbe-srv/view/entry/3H3G PDB 3H4Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3H4Z PDB 3HPI http://www.ebi.ac.uk/pdbe-srv/view/entry/3HPI PDB 3HST http://www.ebi.ac.uk/pdbe-srv/view/entry/3HST PDB 3IO4 http://www.ebi.ac.uk/pdbe-srv/view/entry/3IO4 PDB 3IO6 http://www.ebi.ac.uk/pdbe-srv/view/entry/3IO6 PDB 3IOR http://www.ebi.ac.uk/pdbe-srv/view/entry/3IOR PDB 3IOT http://www.ebi.ac.uk/pdbe-srv/view/entry/3IOT PDB 3IOU http://www.ebi.ac.uk/pdbe-srv/view/entry/3IOU PDB 3IOV http://www.ebi.ac.uk/pdbe-srv/view/entry/3IOV PDB 3IOW http://www.ebi.ac.uk/pdbe-srv/view/entry/3IOW PDB 3J9P http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9P PDB 3KJT http://www.ebi.ac.uk/pdbe-srv/view/entry/3KJT PDB 3L2J http://www.ebi.ac.uk/pdbe-srv/view/entry/3L2J PDB 3LBS http://www.ebi.ac.uk/pdbe-srv/view/entry/3LBS PDB 3LC8 http://www.ebi.ac.uk/pdbe-srv/view/entry/3LC8 PDB 3MBP http://www.ebi.ac.uk/pdbe-srv/view/entry/3MBP PDB 3MP1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3MP1 PDB 3MP6 http://www.ebi.ac.uk/pdbe-srv/view/entry/3MP6 PDB 3MP8 http://www.ebi.ac.uk/pdbe-srv/view/entry/3MP8 PDB 3MQ9 http://www.ebi.ac.uk/pdbe-srv/view/entry/3MQ9 PDB 3N94 http://www.ebi.ac.uk/pdbe-srv/view/entry/3N94 PDB 3O3U http://www.ebi.ac.uk/pdbe-srv/view/entry/3O3U PDB 3OAI http://www.ebi.ac.uk/pdbe-srv/view/entry/3OAI PDB 3OSQ http://www.ebi.ac.uk/pdbe-srv/view/entry/3OSQ PDB 3OSR http://www.ebi.ac.uk/pdbe-srv/view/entry/3OSR PDB 3PGF http://www.ebi.ac.uk/pdbe-srv/view/entry/3PGF PDB 3PUV http://www.ebi.ac.uk/pdbe-srv/view/entry/3PUV PDB 3PUW http://www.ebi.ac.uk/pdbe-srv/view/entry/3PUW PDB 3PUX http://www.ebi.ac.uk/pdbe-srv/view/entry/3PUX PDB 3PUY http://www.ebi.ac.uk/pdbe-srv/view/entry/3PUY PDB 3PUZ http://www.ebi.ac.uk/pdbe-srv/view/entry/3PUZ PDB 3PV0 http://www.ebi.ac.uk/pdbe-srv/view/entry/3PV0 PDB 3PY7 http://www.ebi.ac.uk/pdbe-srv/view/entry/3PY7 PDB 3Q25 http://www.ebi.ac.uk/pdbe-srv/view/entry/3Q25 PDB 3Q26 http://www.ebi.ac.uk/pdbe-srv/view/entry/3Q26 PDB 3Q27 http://www.ebi.ac.uk/pdbe-srv/view/entry/3Q27 PDB 3Q28 http://www.ebi.ac.uk/pdbe-srv/view/entry/3Q28 PDB 3Q29 http://www.ebi.ac.uk/pdbe-srv/view/entry/3Q29 PDB 3RLF http://www.ebi.ac.uk/pdbe-srv/view/entry/3RLF PDB 3RUM http://www.ebi.ac.uk/pdbe-srv/view/entry/3RUM PDB 3SER http://www.ebi.ac.uk/pdbe-srv/view/entry/3SER PDB 3SES http://www.ebi.ac.uk/pdbe-srv/view/entry/3SES PDB 3SET http://www.ebi.ac.uk/pdbe-srv/view/entry/3SET PDB 3SEU http://www.ebi.ac.uk/pdbe-srv/view/entry/3SEU PDB 3SEV http://www.ebi.ac.uk/pdbe-srv/view/entry/3SEV PDB 3SEW http://www.ebi.ac.uk/pdbe-srv/view/entry/3SEW PDB 3SEX http://www.ebi.ac.uk/pdbe-srv/view/entry/3SEX PDB 3SEY http://www.ebi.ac.uk/pdbe-srv/view/entry/3SEY PDB 3VFJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3VFJ PDB 3W15 http://www.ebi.ac.uk/pdbe-srv/view/entry/3W15 PDB 3WAI http://www.ebi.ac.uk/pdbe-srv/view/entry/3WAI PDB 3WOA http://www.ebi.ac.uk/pdbe-srv/view/entry/3WOA PDB 4B3N http://www.ebi.ac.uk/pdbe-srv/view/entry/4B3N PDB 4BL8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4BL8 PDB 4BL9 http://www.ebi.ac.uk/pdbe-srv/view/entry/4BL9 PDB 4BLA http://www.ebi.ac.uk/pdbe-srv/view/entry/4BLA PDB 4BLB http://www.ebi.ac.uk/pdbe-srv/view/entry/4BLB PDB 4BLD http://www.ebi.ac.uk/pdbe-srv/view/entry/4BLD PDB 4DXB http://www.ebi.ac.uk/pdbe-srv/view/entry/4DXB PDB 4DXC http://www.ebi.ac.uk/pdbe-srv/view/entry/4DXC PDB 4EDQ http://www.ebi.ac.uk/pdbe-srv/view/entry/4EDQ PDB 4EGC http://www.ebi.ac.uk/pdbe-srv/view/entry/4EGC PDB 4EXK http://www.ebi.ac.uk/pdbe-srv/view/entry/4EXK PDB 4FE8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4FE8 PDB 4FEB http://www.ebi.ac.uk/pdbe-srv/view/entry/4FEB PDB 4FEC http://www.ebi.ac.uk/pdbe-srv/view/entry/4FEC PDB 4FED http://www.ebi.ac.uk/pdbe-srv/view/entry/4FED PDB 4GIZ http://www.ebi.ac.uk/pdbe-srv/view/entry/4GIZ PDB 4GLI http://www.ebi.ac.uk/pdbe-srv/view/entry/4GLI PDB 4IFP http://www.ebi.ac.uk/pdbe-srv/view/entry/4IFP PDB 4IKM http://www.ebi.ac.uk/pdbe-srv/view/entry/4IKM PDB 4IRL http://www.ebi.ac.uk/pdbe-srv/view/entry/4IRL PDB 4JBZ http://www.ebi.ac.uk/pdbe-srv/view/entry/4JBZ PDB 4JKM http://www.ebi.ac.uk/pdbe-srv/view/entry/4JKM PDB 4KEG http://www.ebi.ac.uk/pdbe-srv/view/entry/4KEG PDB 4KHZ http://www.ebi.ac.uk/pdbe-srv/view/entry/4KHZ PDB 4KI0 http://www.ebi.ac.uk/pdbe-srv/view/entry/4KI0 PDB 4KV3 http://www.ebi.ac.uk/pdbe-srv/view/entry/4KV3 PDB 4KYC http://www.ebi.ac.uk/pdbe-srv/view/entry/4KYC PDB 4KYD http://www.ebi.ac.uk/pdbe-srv/view/entry/4KYD PDB 4KYE http://www.ebi.ac.uk/pdbe-srv/view/entry/4KYE PDB 4LOG http://www.ebi.ac.uk/pdbe-srv/view/entry/4LOG PDB 4MBP http://www.ebi.ac.uk/pdbe-srv/view/entry/4MBP PDB 4N4X http://www.ebi.ac.uk/pdbe-srv/view/entry/4N4X PDB 4NDZ http://www.ebi.ac.uk/pdbe-srv/view/entry/4NDZ PDB 4O2X http://www.ebi.ac.uk/pdbe-srv/view/entry/4O2X PDB 4OGM http://www.ebi.ac.uk/pdbe-srv/view/entry/4OGM PDB 4PE2 http://www.ebi.ac.uk/pdbe-srv/view/entry/4PE2 PDB 4QSZ http://www.ebi.ac.uk/pdbe-srv/view/entry/4QSZ PDB 4QVH http://www.ebi.ac.uk/pdbe-srv/view/entry/4QVH PDB 4R0Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4R0Y PDB 4RG5 http://www.ebi.ac.uk/pdbe-srv/view/entry/4RG5 PDB 4RWF http://www.ebi.ac.uk/pdbe-srv/view/entry/4RWF PDB 4RWG http://www.ebi.ac.uk/pdbe-srv/view/entry/4RWG PDB 4TSM http://www.ebi.ac.uk/pdbe-srv/view/entry/4TSM PDB 4WJV http://www.ebi.ac.uk/pdbe-srv/view/entry/4WJV PDB 4WMS http://www.ebi.ac.uk/pdbe-srv/view/entry/4WMS PDB 4WMT http://www.ebi.ac.uk/pdbe-srv/view/entry/4WMT PDB 4WMU http://www.ebi.ac.uk/pdbe-srv/view/entry/4WMU PDB 4WMV http://www.ebi.ac.uk/pdbe-srv/view/entry/4WMV PDB 4WMW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WMW PDB 4WMX http://www.ebi.ac.uk/pdbe-srv/view/entry/4WMX PDB 4WRN http://www.ebi.ac.uk/pdbe-srv/view/entry/4WRN PDB 4WTH http://www.ebi.ac.uk/pdbe-srv/view/entry/4WTH PDB 4WVH http://www.ebi.ac.uk/pdbe-srv/view/entry/4WVH PDB 4XA2 http://www.ebi.ac.uk/pdbe-srv/view/entry/4XA2 PDB 4XHS http://www.ebi.ac.uk/pdbe-srv/view/entry/4XHS PDB 4XR8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4XR8 PDB 4XZS http://www.ebi.ac.uk/pdbe-srv/view/entry/4XZS PDB 4XZV http://www.ebi.ac.uk/pdbe-srv/view/entry/4XZV PDB 5AQ9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5AQ9 PDB 5AZ6 http://www.ebi.ac.uk/pdbe-srv/view/entry/5AZ6 PDB 5AZ7 http://www.ebi.ac.uk/pdbe-srv/view/entry/5AZ7 PDB 5AZ8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5AZ8 PDB 5AZ9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5AZ9 PDB 5AZA http://www.ebi.ac.uk/pdbe-srv/view/entry/5AZA PDB 5C7R http://www.ebi.ac.uk/pdbe-srv/view/entry/5C7R PDB 5CBN http://www.ebi.ac.uk/pdbe-srv/view/entry/5CBN PDB 5CFV http://www.ebi.ac.uk/pdbe-srv/view/entry/5CFV PDB 5DFM http://www.ebi.ac.uk/pdbe-srv/view/entry/5DFM PDB 5DIS http://www.ebi.ac.uk/pdbe-srv/view/entry/5DIS PDB 5E24 http://www.ebi.ac.uk/pdbe-srv/view/entry/5E24 PDB 5EDU http://www.ebi.ac.uk/pdbe-srv/view/entry/5EDU PDB 5FSG http://www.ebi.ac.uk/pdbe-srv/view/entry/5FSG PDB 5GRU http://www.ebi.ac.uk/pdbe-srv/view/entry/5GRU PDB 5GS2 http://www.ebi.ac.uk/pdbe-srv/view/entry/5GS2 PDB 5HZ7 http://www.ebi.ac.uk/pdbe-srv/view/entry/5HZ7 PDB 5I69 http://www.ebi.ac.uk/pdbe-srv/view/entry/5I69 PDB 5IHJ http://www.ebi.ac.uk/pdbe-srv/view/entry/5IHJ PDB 5IQZ http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQZ PDB 5JJ4 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JJ4 PDB 5JTQ http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTQ PDB 5JTR http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTR PDB 5LDF http://www.ebi.ac.uk/pdbe-srv/view/entry/5LDF PDBsum 1A7L http://www.ebi.ac.uk/pdbsum/1A7L PDBsum 1ANF http://www.ebi.ac.uk/pdbsum/1ANF PDBsum 1DMB http://www.ebi.ac.uk/pdbsum/1DMB PDBsum 1EZ9 http://www.ebi.ac.uk/pdbsum/1EZ9 PDBsum 1EZO http://www.ebi.ac.uk/pdbsum/1EZO PDBsum 1EZP http://www.ebi.ac.uk/pdbsum/1EZP PDBsum 1FQA http://www.ebi.ac.uk/pdbsum/1FQA PDBsum 1FQB http://www.ebi.ac.uk/pdbsum/1FQB PDBsum 1FQC http://www.ebi.ac.uk/pdbsum/1FQC PDBsum 1FQD http://www.ebi.ac.uk/pdbsum/1FQD PDBsum 1HSJ http://www.ebi.ac.uk/pdbsum/1HSJ PDBsum 1IUD http://www.ebi.ac.uk/pdbsum/1IUD PDBsum 1JVX http://www.ebi.ac.uk/pdbsum/1JVX PDBsum 1JVY http://www.ebi.ac.uk/pdbsum/1JVY PDBsum 1JW4 http://www.ebi.ac.uk/pdbsum/1JW4 PDBsum 1JW5 http://www.ebi.ac.uk/pdbsum/1JW5 PDBsum 1LAX http://www.ebi.ac.uk/pdbsum/1LAX PDBsum 1LLS http://www.ebi.ac.uk/pdbsum/1LLS PDBsum 1MDP http://www.ebi.ac.uk/pdbsum/1MDP PDBsum 1MDQ http://www.ebi.ac.uk/pdbsum/1MDQ PDBsum 1MG1 http://www.ebi.ac.uk/pdbsum/1MG1 PDBsum 1MH3 http://www.ebi.ac.uk/pdbsum/1MH3 PDBsum 1MH4 http://www.ebi.ac.uk/pdbsum/1MH4 PDBsum 1MPB http://www.ebi.ac.uk/pdbsum/1MPB PDBsum 1MPC http://www.ebi.ac.uk/pdbsum/1MPC PDBsum 1MPD http://www.ebi.ac.uk/pdbsum/1MPD PDBsum 1N3W http://www.ebi.ac.uk/pdbsum/1N3W PDBsum 1N3X http://www.ebi.ac.uk/pdbsum/1N3X PDBsum 1NL5 http://www.ebi.ac.uk/pdbsum/1NL5 PDBsum 1NMU http://www.ebi.ac.uk/pdbsum/1NMU PDBsum 1OMP http://www.ebi.ac.uk/pdbsum/1OMP PDBsum 1PEB http://www.ebi.ac.uk/pdbsum/1PEB PDBsum 1R6Z http://www.ebi.ac.uk/pdbsum/1R6Z PDBsum 1SVX http://www.ebi.ac.uk/pdbsum/1SVX PDBsum 1T0K http://www.ebi.ac.uk/pdbsum/1T0K PDBsum 1Y4C http://www.ebi.ac.uk/pdbsum/1Y4C PDBsum 1YTV http://www.ebi.ac.uk/pdbsum/1YTV PDBsum 1ZIU http://www.ebi.ac.uk/pdbsum/1ZIU PDBsum 1ZJL http://www.ebi.ac.uk/pdbsum/1ZJL PDBsum 1ZKB http://www.ebi.ac.uk/pdbsum/1ZKB PDBsum 1ZMG http://www.ebi.ac.uk/pdbsum/1ZMG PDBsum 2D21 http://www.ebi.ac.uk/pdbsum/2D21 PDBsum 2H25 http://www.ebi.ac.uk/pdbsum/2H25 PDBsum 2KLF http://www.ebi.ac.uk/pdbsum/2KLF PDBsum 2MV0 http://www.ebi.ac.uk/pdbsum/2MV0 PDBsum 2N44 http://www.ebi.ac.uk/pdbsum/2N44 PDBsum 2N45 http://www.ebi.ac.uk/pdbsum/2N45 PDBsum 2NVU http://www.ebi.ac.uk/pdbsum/2NVU PDBsum 2OBG http://www.ebi.ac.uk/pdbsum/2OBG PDBsum 2OK2 http://www.ebi.ac.uk/pdbsum/2OK2 PDBsum 2R6G http://www.ebi.ac.uk/pdbsum/2R6G PDBsum 2V93 http://www.ebi.ac.uk/pdbsum/2V93 PDBsum 2VGQ http://www.ebi.ac.uk/pdbsum/2VGQ PDBsum 2XZ3 http://www.ebi.ac.uk/pdbsum/2XZ3 PDBsum 2ZXT http://www.ebi.ac.uk/pdbsum/2ZXT PDBsum 3A3C http://www.ebi.ac.uk/pdbsum/3A3C PDBsum 3C4M http://www.ebi.ac.uk/pdbsum/3C4M PDBsum 3CSB http://www.ebi.ac.uk/pdbsum/3CSB PDBsum 3CSG http://www.ebi.ac.uk/pdbsum/3CSG PDBsum 3D4C http://www.ebi.ac.uk/pdbsum/3D4C PDBsum 3DM0 http://www.ebi.ac.uk/pdbsum/3DM0 PDBsum 3EHS http://www.ebi.ac.uk/pdbsum/3EHS PDBsum 3EHT http://www.ebi.ac.uk/pdbsum/3EHT PDBsum 3EHU http://www.ebi.ac.uk/pdbsum/3EHU PDBsum 3F5F http://www.ebi.ac.uk/pdbsum/3F5F PDBsum 3G7V http://www.ebi.ac.uk/pdbsum/3G7V PDBsum 3G7W http://www.ebi.ac.uk/pdbsum/3G7W PDBsum 3H3G http://www.ebi.ac.uk/pdbsum/3H3G PDBsum 3H4Z http://www.ebi.ac.uk/pdbsum/3H4Z PDBsum 3HPI http://www.ebi.ac.uk/pdbsum/3HPI PDBsum 3HST http://www.ebi.ac.uk/pdbsum/3HST PDBsum 3IO4 http://www.ebi.ac.uk/pdbsum/3IO4 PDBsum 3IO6 http://www.ebi.ac.uk/pdbsum/3IO6 PDBsum 3IOR http://www.ebi.ac.uk/pdbsum/3IOR PDBsum 3IOT http://www.ebi.ac.uk/pdbsum/3IOT PDBsum 3IOU http://www.ebi.ac.uk/pdbsum/3IOU PDBsum 3IOV http://www.ebi.ac.uk/pdbsum/3IOV PDBsum 3IOW http://www.ebi.ac.uk/pdbsum/3IOW PDBsum 3J9P http://www.ebi.ac.uk/pdbsum/3J9P PDBsum 3KJT http://www.ebi.ac.uk/pdbsum/3KJT PDBsum 3L2J http://www.ebi.ac.uk/pdbsum/3L2J PDBsum 3LBS http://www.ebi.ac.uk/pdbsum/3LBS PDBsum 3LC8 http://www.ebi.ac.uk/pdbsum/3LC8 PDBsum 3MBP http://www.ebi.ac.uk/pdbsum/3MBP PDBsum 3MP1 http://www.ebi.ac.uk/pdbsum/3MP1 PDBsum 3MP6 http://www.ebi.ac.uk/pdbsum/3MP6 PDBsum 3MP8 http://www.ebi.ac.uk/pdbsum/3MP8 PDBsum 3MQ9 http://www.ebi.ac.uk/pdbsum/3MQ9 PDBsum 3N94 http://www.ebi.ac.uk/pdbsum/3N94 PDBsum 3O3U http://www.ebi.ac.uk/pdbsum/3O3U PDBsum 3OAI http://www.ebi.ac.uk/pdbsum/3OAI PDBsum 3OSQ http://www.ebi.ac.uk/pdbsum/3OSQ PDBsum 3OSR http://www.ebi.ac.uk/pdbsum/3OSR PDBsum 3PGF http://www.ebi.ac.uk/pdbsum/3PGF PDBsum 3PUV http://www.ebi.ac.uk/pdbsum/3PUV PDBsum 3PUW http://www.ebi.ac.uk/pdbsum/3PUW PDBsum 3PUX http://www.ebi.ac.uk/pdbsum/3PUX PDBsum 3PUY http://www.ebi.ac.uk/pdbsum/3PUY PDBsum 3PUZ http://www.ebi.ac.uk/pdbsum/3PUZ PDBsum 3PV0 http://www.ebi.ac.uk/pdbsum/3PV0 PDBsum 3PY7 http://www.ebi.ac.uk/pdbsum/3PY7 PDBsum 3Q25 http://www.ebi.ac.uk/pdbsum/3Q25 PDBsum 3Q26 http://www.ebi.ac.uk/pdbsum/3Q26 PDBsum 3Q27 http://www.ebi.ac.uk/pdbsum/3Q27 PDBsum 3Q28 http://www.ebi.ac.uk/pdbsum/3Q28 PDBsum 3Q29 http://www.ebi.ac.uk/pdbsum/3Q29 PDBsum 3RLF http://www.ebi.ac.uk/pdbsum/3RLF PDBsum 3RUM http://www.ebi.ac.uk/pdbsum/3RUM PDBsum 3SER http://www.ebi.ac.uk/pdbsum/3SER PDBsum 3SES http://www.ebi.ac.uk/pdbsum/3SES PDBsum 3SET http://www.ebi.ac.uk/pdbsum/3SET PDBsum 3SEU http://www.ebi.ac.uk/pdbsum/3SEU PDBsum 3SEV http://www.ebi.ac.uk/pdbsum/3SEV PDBsum 3SEW http://www.ebi.ac.uk/pdbsum/3SEW PDBsum 3SEX http://www.ebi.ac.uk/pdbsum/3SEX PDBsum 3SEY http://www.ebi.ac.uk/pdbsum/3SEY PDBsum 3VFJ http://www.ebi.ac.uk/pdbsum/3VFJ PDBsum 3W15 http://www.ebi.ac.uk/pdbsum/3W15 PDBsum 3WAI http://www.ebi.ac.uk/pdbsum/3WAI PDBsum 3WOA http://www.ebi.ac.uk/pdbsum/3WOA PDBsum 4B3N http://www.ebi.ac.uk/pdbsum/4B3N PDBsum 4BL8 http://www.ebi.ac.uk/pdbsum/4BL8 PDBsum 4BL9 http://www.ebi.ac.uk/pdbsum/4BL9 PDBsum 4BLA http://www.ebi.ac.uk/pdbsum/4BLA PDBsum 4BLB http://www.ebi.ac.uk/pdbsum/4BLB PDBsum 4BLD http://www.ebi.ac.uk/pdbsum/4BLD PDBsum 4DXB http://www.ebi.ac.uk/pdbsum/4DXB PDBsum 4DXC http://www.ebi.ac.uk/pdbsum/4DXC PDBsum 4EDQ http://www.ebi.ac.uk/pdbsum/4EDQ PDBsum 4EGC http://www.ebi.ac.uk/pdbsum/4EGC PDBsum 4EXK http://www.ebi.ac.uk/pdbsum/4EXK PDBsum 4FE8 http://www.ebi.ac.uk/pdbsum/4FE8 PDBsum 4FEB http://www.ebi.ac.uk/pdbsum/4FEB PDBsum 4FEC http://www.ebi.ac.uk/pdbsum/4FEC PDBsum 4FED http://www.ebi.ac.uk/pdbsum/4FED PDBsum 4GIZ http://www.ebi.ac.uk/pdbsum/4GIZ PDBsum 4GLI http://www.ebi.ac.uk/pdbsum/4GLI PDBsum 4IFP http://www.ebi.ac.uk/pdbsum/4IFP PDBsum 4IKM http://www.ebi.ac.uk/pdbsum/4IKM PDBsum 4IRL http://www.ebi.ac.uk/pdbsum/4IRL PDBsum 4JBZ http://www.ebi.ac.uk/pdbsum/4JBZ PDBsum 4JKM http://www.ebi.ac.uk/pdbsum/4JKM PDBsum 4KEG http://www.ebi.ac.uk/pdbsum/4KEG PDBsum 4KHZ http://www.ebi.ac.uk/pdbsum/4KHZ PDBsum 4KI0 http://www.ebi.ac.uk/pdbsum/4KI0 PDBsum 4KV3 http://www.ebi.ac.uk/pdbsum/4KV3 PDBsum 4KYC http://www.ebi.ac.uk/pdbsum/4KYC PDBsum 4KYD http://www.ebi.ac.uk/pdbsum/4KYD PDBsum 4KYE http://www.ebi.ac.uk/pdbsum/4KYE PDBsum 4LOG http://www.ebi.ac.uk/pdbsum/4LOG PDBsum 4MBP http://www.ebi.ac.uk/pdbsum/4MBP PDBsum 4N4X http://www.ebi.ac.uk/pdbsum/4N4X PDBsum 4NDZ http://www.ebi.ac.uk/pdbsum/4NDZ PDBsum 4O2X http://www.ebi.ac.uk/pdbsum/4O2X PDBsum 4OGM http://www.ebi.ac.uk/pdbsum/4OGM PDBsum 4PE2 http://www.ebi.ac.uk/pdbsum/4PE2 PDBsum 4QSZ http://www.ebi.ac.uk/pdbsum/4QSZ PDBsum 4QVH http://www.ebi.ac.uk/pdbsum/4QVH PDBsum 4R0Y http://www.ebi.ac.uk/pdbsum/4R0Y PDBsum 4RG5 http://www.ebi.ac.uk/pdbsum/4RG5 PDBsum 4RWF http://www.ebi.ac.uk/pdbsum/4RWF PDBsum 4RWG http://www.ebi.ac.uk/pdbsum/4RWG PDBsum 4TSM http://www.ebi.ac.uk/pdbsum/4TSM PDBsum 4WJV http://www.ebi.ac.uk/pdbsum/4WJV PDBsum 4WMS http://www.ebi.ac.uk/pdbsum/4WMS PDBsum 4WMT http://www.ebi.ac.uk/pdbsum/4WMT PDBsum 4WMU http://www.ebi.ac.uk/pdbsum/4WMU PDBsum 4WMV http://www.ebi.ac.uk/pdbsum/4WMV PDBsum 4WMW http://www.ebi.ac.uk/pdbsum/4WMW PDBsum 4WMX http://www.ebi.ac.uk/pdbsum/4WMX PDBsum 4WRN http://www.ebi.ac.uk/pdbsum/4WRN PDBsum 4WTH http://www.ebi.ac.uk/pdbsum/4WTH PDBsum 4WVH http://www.ebi.ac.uk/pdbsum/4WVH PDBsum 4XA2 http://www.ebi.ac.uk/pdbsum/4XA2 PDBsum 4XHS http://www.ebi.ac.uk/pdbsum/4XHS PDBsum 4XR8 http://www.ebi.ac.uk/pdbsum/4XR8 PDBsum 4XZS http://www.ebi.ac.uk/pdbsum/4XZS PDBsum 4XZV http://www.ebi.ac.uk/pdbsum/4XZV PDBsum 5AQ9 http://www.ebi.ac.uk/pdbsum/5AQ9 PDBsum 5AZ6 http://www.ebi.ac.uk/pdbsum/5AZ6 PDBsum 5AZ7 http://www.ebi.ac.uk/pdbsum/5AZ7 PDBsum 5AZ8 http://www.ebi.ac.uk/pdbsum/5AZ8 PDBsum 5AZ9 http://www.ebi.ac.uk/pdbsum/5AZ9 PDBsum 5AZA http://www.ebi.ac.uk/pdbsum/5AZA PDBsum 5C7R http://www.ebi.ac.uk/pdbsum/5C7R PDBsum 5CBN http://www.ebi.ac.uk/pdbsum/5CBN PDBsum 5CFV http://www.ebi.ac.uk/pdbsum/5CFV PDBsum 5DFM http://www.ebi.ac.uk/pdbsum/5DFM PDBsum 5DIS http://www.ebi.ac.uk/pdbsum/5DIS PDBsum 5E24 http://www.ebi.ac.uk/pdbsum/5E24 PDBsum 5EDU http://www.ebi.ac.uk/pdbsum/5EDU PDBsum 5FSG http://www.ebi.ac.uk/pdbsum/5FSG PDBsum 5GRU http://www.ebi.ac.uk/pdbsum/5GRU PDBsum 5GS2 http://www.ebi.ac.uk/pdbsum/5GS2 PDBsum 5HZ7 http://www.ebi.ac.uk/pdbsum/5HZ7 PDBsum 5I69 http://www.ebi.ac.uk/pdbsum/5I69 PDBsum 5IHJ http://www.ebi.ac.uk/pdbsum/5IHJ PDBsum 5IQZ http://www.ebi.ac.uk/pdbsum/5IQZ PDBsum 5JJ4 http://www.ebi.ac.uk/pdbsum/5JJ4 PDBsum 5JTQ http://www.ebi.ac.uk/pdbsum/5JTQ PDBsum 5JTR http://www.ebi.ac.uk/pdbsum/5JTR PDBsum 5LDF http://www.ebi.ac.uk/pdbsum/5LDF PRINTS PR00181 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00181 PROSITE PS01037 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01037 PSORT swissprot:MALE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MALE_ECOLI PSORT-B swissprot:MALE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MALE_ECOLI PSORT2 swissprot:MALE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MALE_ECOLI Phobius swissprot:MALE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MALE_ECOLI PhylomeDB P0AEX9 http://phylomedb.org/?seqid=P0AEX9 ProteinModelPortal P0AEX9 http://www.proteinmodelportal.org/query/uniprot/P0AEX9 PubMed 1420181 http://www.ncbi.nlm.nih.gov/pubmed/1420181 PubMed 14527658 http://www.ncbi.nlm.nih.gov/pubmed/14527658 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19022906 http://www.ncbi.nlm.nih.gov/pubmed/19022906 PubMed 2002054 http://www.ncbi.nlm.nih.gov/pubmed/2002054 PubMed 6088507 http://www.ncbi.nlm.nih.gov/pubmed/6088507 PubMed 6088520 http://www.ncbi.nlm.nih.gov/pubmed/6088520 PubMed 6185687 http://www.ncbi.nlm.nih.gov/pubmed/6185687 PubMed 6283312 http://www.ncbi.nlm.nih.gov/pubmed/6283312 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9309217 http://www.ncbi.nlm.nih.gov/pubmed/9309217 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 RefSeq NP_418458 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418458 RefSeq WP_000695387 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000695387 SMR P0AEX9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEX9 STRING 511145.b4034 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4034&targetmode=cogs STRING COG2182 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2182&targetmode=cogs SWISS-2DPAGE P0AEX9 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AEX9 TCDB 3.A.1.1 http://www.tcdb.org/search/result.php?tc=3.A.1.1 UniProtKB MALE_ECOLI http://www.uniprot.org/uniprot/MALE_ECOLI UniProtKB-AC P0AEX9 http://www.uniprot.org/uniprot/P0AEX9 charge swissprot:MALE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MALE_ECOLI eggNOG COG2182 http://eggnogapi.embl.de/nog_data/html/tree/COG2182 eggNOG ENOG4107FKK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107FKK epestfind swissprot:MALE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MALE_ECOLI garnier swissprot:MALE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MALE_ECOLI helixturnhelix swissprot:MALE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MALE_ECOLI hmoment swissprot:MALE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MALE_ECOLI iep swissprot:MALE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MALE_ECOLI inforesidue swissprot:MALE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MALE_ECOLI octanol swissprot:MALE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MALE_ECOLI pepcoil swissprot:MALE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MALE_ECOLI pepdigest swissprot:MALE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MALE_ECOLI pepinfo swissprot:MALE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MALE_ECOLI pepnet swissprot:MALE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MALE_ECOLI pepstats swissprot:MALE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MALE_ECOLI pepwheel swissprot:MALE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MALE_ECOLI pepwindow swissprot:MALE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MALE_ECOLI sigcleave swissprot:MALE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MALE_ECOLI ## Database ID URL or Descriptions # EcoGene EG40006 insF4 # FUNCTION INSF4_ECOLI Involved in the transposition of the insertion sequence IS3. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006310 DNA recombination; IEA:UniProtKB-KW. # GO_process GO:0015074 DNA integration; IEA:InterPro. # GO_process GO:0032196 transposition; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 3.30.420.10 -; 1. # InterPro IPR001584 Integrase_cat-core # InterPro IPR012337 RNaseH-like_dom # InterPro IPR025948 HTH-like_dom # Organism INSF4_ECOLI Escherichia coli (strain K12) # PIR C64756 TQECI3 # PROSITE PS50994 INTEGRASE # Pfam PF00665 rve # Pfam PF13276 HTH_21 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSF4_ECOLI Transposase InsF for insertion sequence IS3D # RefSeq NP_061381 NC_002483.1 # RefSeq NP_414833 NC_000913.3 # RefSeq NP_414906 NC_000913.3 # RefSeq NP_415073 NC_000913.3 # RefSeq NP_415545 NC_000913.3 # RefSeq NP_416593 NC_000913.3 # RefSeq WP_000878218 NZ_LN832404.1 # SIMILARITY Belongs to the transposase IS3/IS150/IS904 family. {ECO 0000305}. # SIMILARITY Contains 1 integrase catalytic domain. {ECO:0000255|PROSITE-ProRule PRU00457}. # SUPFAM SSF53098 SSF53098 # eggNOG COG2801 LUCA BLAST swissprot:INSF4_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSF4_ECOLI DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4720 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4720 EcoGene EG40006 http://www.ecogene.org/geneInfo.php?eg_id=EG40006 EnsemblBacteria AAC74111 http://www.ensemblgenomes.org/id/AAC74111 EnsemblBacteria AAC74111 http://www.ensemblgenomes.org/id/AAC74111 EnsemblBacteria BAE76368 http://www.ensemblgenomes.org/id/BAE76368 EnsemblBacteria BAE76368 http://www.ensemblgenomes.org/id/BAE76368 EnsemblBacteria BAE76368 http://www.ensemblgenomes.org/id/BAE76368 EnsemblBacteria b1026 http://www.ensemblgenomes.org/id/b1026 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0015074 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015074 GO_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 3.30.420.10 http://www.cathdb.info/version/latest/superfamily/3.30.420.10 GeneID 1263587 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263587 GeneID 944948 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944948 GeneID 945036 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945036 GeneID 945587 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945587 GeneID 946629 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946629 GeneID 947988 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947988 InParanoid P0CF82 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CF82 InterPro IPR001584 http://www.ebi.ac.uk/interpro/entry/IPR001584 InterPro IPR012337 http://www.ebi.ac.uk/interpro/entry/IPR012337 InterPro IPR025948 http://www.ebi.ac.uk/interpro/entry/IPR025948 KEGG_Gene ecj:JW1012 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1012 KEGG_Gene eco:b0299 http://www.genome.jp/dbget-bin/www_bget?eco:b0299 KEGG_Gene eco:b0372 http://www.genome.jp/dbget-bin/www_bget?eco:b0372 KEGG_Gene eco:b0541 http://www.genome.jp/dbget-bin/www_bget?eco:b0541 KEGG_Gene eco:b1026 http://www.genome.jp/dbget-bin/www_bget?eco:b1026 KEGG_Gene eco:b2089 http://www.genome.jp/dbget-bin/www_bget?eco:b2089 PROSITE PS50994 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50994 PSORT swissprot:INSF4_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSF4_ECOLI PSORT-B swissprot:INSF4_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSF4_ECOLI PSORT2 swissprot:INSF4_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSF4_ECOLI Pfam PF00665 http://pfam.xfam.org/family/PF00665 Pfam PF13276 http://pfam.xfam.org/family/PF13276 Phobius swissprot:INSF4_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSF4_ECOLI PhylomeDB P0CF82 http://phylomedb.org/?seqid=P0CF82 ProteinModelPortal P0CF82 http://www.proteinmodelportal.org/query/uniprot/P0CF82 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_061381 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061381 RefSeq NP_414833 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414833 RefSeq NP_414906 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414906 RefSeq NP_415073 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415073 RefSeq NP_415545 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415545 RefSeq NP_416593 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416593 RefSeq WP_000878218 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000878218 SMR P0CF82 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0CF82 STRING 511145.b2089 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2089&targetmode=cogs SUPFAM SSF53098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098 UniProtKB INSF4_ECOLI http://www.uniprot.org/uniprot/INSF4_ECOLI UniProtKB-AC P0CF82 http://www.uniprot.org/uniprot/P0CF82 charge swissprot:INSF4_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSF4_ECOLI eggNOG COG2801 http://eggnogapi.embl.de/nog_data/html/tree/COG2801 epestfind swissprot:INSF4_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSF4_ECOLI garnier swissprot:INSF4_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSF4_ECOLI helixturnhelix swissprot:INSF4_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSF4_ECOLI hmoment swissprot:INSF4_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSF4_ECOLI iep swissprot:INSF4_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSF4_ECOLI inforesidue swissprot:INSF4_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSF4_ECOLI octanol swissprot:INSF4_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSF4_ECOLI pepcoil swissprot:INSF4_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSF4_ECOLI pepdigest swissprot:INSF4_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSF4_ECOLI pepinfo swissprot:INSF4_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSF4_ECOLI pepnet swissprot:INSF4_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSF4_ECOLI pepstats swissprot:INSF4_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSF4_ECOLI pepwheel swissprot:INSF4_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSF4_ECOLI pepwindow swissprot:INSF4_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSF4_ECOLI sigcleave swissprot:INSF4_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSF4_ECOLI ## Database ID URL or Descriptions # BioGrid 4262927 168 # EcoGene EG12906 yhfK # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR010020 Integral_membrane_YCCS_YHJK # InterPro IPR032692 YccS_N # Organism YHFK_ECOLI Escherichia coli (strain K12) # PATRIC 32122150 VBIEscCol129921_3452 # Pfam PF12805 FUSC-like # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHFK_ECOLI Uncharacterized protein YhfK # RefSeq NP_417817 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA58155.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the YccS/YhfK family. {ECO 0000305}. # SUBCELLULAR LOCATION YHFK_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # TCDB 2.A.85.1 the aromatic acid exporter (arae) family # TIGRFAMs TIGR01667 YCCS_YHJK # eggNOG COG1289 LUCA # eggNOG ENOG410613R Bacteria BLAST swissprot:YHFK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHFK_ECOLI BioCyc ECOL316407:JW5701-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5701-MONOMER BioCyc EcoCyc:G7721-MONOMER http://biocyc.org/getid?id=EcoCyc:G7721-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2743 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2743 EcoGene EG12906 http://www.ecogene.org/geneInfo.php?eg_id=EG12906 EnsemblBacteria AAC76383 http://www.ensemblgenomes.org/id/AAC76383 EnsemblBacteria AAC76383 http://www.ensemblgenomes.org/id/AAC76383 EnsemblBacteria BAE77932 http://www.ensemblgenomes.org/id/BAE77932 EnsemblBacteria BAE77932 http://www.ensemblgenomes.org/id/BAE77932 EnsemblBacteria BAE77932 http://www.ensemblgenomes.org/id/BAE77932 EnsemblBacteria b3358 http://www.ensemblgenomes.org/id/b3358 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 947866 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947866 HOGENOM HOG000125430 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125430&db=HOGENOM6 InParanoid P45537 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45537 InterPro IPR010020 http://www.ebi.ac.uk/interpro/entry/IPR010020 InterPro IPR032692 http://www.ebi.ac.uk/interpro/entry/IPR032692 KEGG_Gene ecj:JW5701 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5701 KEGG_Gene eco:b3358 http://www.genome.jp/dbget-bin/www_bget?eco:b3358 OMA ERAMDTA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ERAMDTA PSORT swissprot:YHFK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHFK_ECOLI PSORT-B swissprot:YHFK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHFK_ECOLI PSORT2 swissprot:YHFK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHFK_ECOLI Pfam PF12805 http://pfam.xfam.org/family/PF12805 Phobius swissprot:YHFK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHFK_ECOLI PhylomeDB P45537 http://phylomedb.org/?seqid=P45537 ProteinModelPortal P45537 http://www.proteinmodelportal.org/query/uniprot/P45537 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417817 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417817 SMR P45537 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45537 STRING 511145.b3358 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3358&targetmode=cogs TCDB 2.A.85.1 http://www.tcdb.org/search/result.php?tc=2.A.85.1 TIGRFAMs TIGR01667 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01667 UniProtKB YHFK_ECOLI http://www.uniprot.org/uniprot/YHFK_ECOLI UniProtKB-AC P45537 http://www.uniprot.org/uniprot/P45537 charge swissprot:YHFK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHFK_ECOLI eggNOG COG1289 http://eggnogapi.embl.de/nog_data/html/tree/COG1289 eggNOG ENOG410613R http://eggnogapi.embl.de/nog_data/html/tree/ENOG410613R epestfind swissprot:YHFK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHFK_ECOLI garnier swissprot:YHFK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHFK_ECOLI helixturnhelix swissprot:YHFK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHFK_ECOLI hmoment swissprot:YHFK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHFK_ECOLI iep swissprot:YHFK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHFK_ECOLI inforesidue swissprot:YHFK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHFK_ECOLI octanol swissprot:YHFK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHFK_ECOLI pepcoil swissprot:YHFK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHFK_ECOLI pepdigest swissprot:YHFK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHFK_ECOLI pepinfo swissprot:YHFK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHFK_ECOLI pepnet swissprot:YHFK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHFK_ECOLI pepstats swissprot:YHFK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHFK_ECOLI pepwheel swissprot:YHFK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHFK_ECOLI pepwindow swissprot:YHFK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHFK_ECOLI sigcleave swissprot:YHFK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHFK_ECOLI ## Database ID URL or Descriptions # AltName SYN_ECOLI Asparaginyl-tRNA synthetase # CATALYTIC ACTIVITY SYN_ECOLI ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn). # EcoGene EG10094 asnS # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003676 nucleic acid binding; IEA:InterPro. # GO_function GO:0004816 asparagine-tRNA ligase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IMP:EcoCyc. # GO_process GO:0006418 tRNA aminoacylation for protein translation; IDA:EcoCyc. # GO_process GO:0006421 asparaginyl-tRNA aminoacylation; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0006520 cellular amino acid metabolic process # HAMAP MF_00534 Asn_tRNA_synth # IntAct P0A8M0 3 # InterPro IPR002312 Asp/Asn-tRNA-synth_IIb # InterPro IPR004364 aa-tRNA-synt_II # InterPro IPR004365 NA-bd_OB_tRNA # InterPro IPR004522 Asn-tRNA-ligase # InterPro IPR006195 aa-tRNA-synth_II # InterPro IPR012340 NA-bd_OB-fold # InterPro IPR018150 aa-tRNA-synt_II-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01007 Amino acid related enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # KEGG_Pathway ko00970 Aminoacyl-tRNA biosynthesis # Organism SYN_ECOLI Escherichia coli (strain K12) # PANTHER PTHR22594 PTHR22594; 2 # PANTHER PTHR22594:SF6 PTHR22594:SF6; 2 # PATRIC 32117077 VBIEscCol129921_0963 # PIR JS0396 SYECNT # PRINTS PR01042 TRNASYNTHASP # PROSITE PS50862 AA_TRNA_LIGASE_II # Pfam PF00152 tRNA-synt_2 # Pfam PF01336 tRNA_anti-codon # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SYN_ECOLI Asparagine--tRNA ligase # RefSeq NP_415450 NC_000913.3 # RefSeq WP_000117881 NZ_LN832404.1 # SIMILARITY Belongs to the class-II aminoacyl-tRNA synthetase family. {ECO 0000305}. # SUBCELLULAR LOCATION SYN_ECOLI Cytoplasm. # SUBUNIT SYN_ECOLI Homodimer. # SUPFAM SSF50249 SSF50249 # TIGRFAMs TIGR00457 asnS # eggNOG COG0017 LUCA # eggNOG ENOG4105C5S Bacteria BLAST swissprot:SYN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SYN_ECOLI BioCyc ECOL316407:JW0913-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0913-MONOMER BioCyc EcoCyc:ASNS-MONOMER http://biocyc.org/getid?id=EcoCyc:ASNS-MONOMER BioCyc MetaCyc:ASNS-MONOMER http://biocyc.org/getid?id=MetaCyc:ASNS-MONOMER COG COG0017 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0017 DIP DIP-9179N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9179N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1016/0014-5793(91)80228-U http://dx.doi.org/10.1016/0014-5793(91)80228-U DOI 10.1016/0014-5793(92)80106-Q http://dx.doi.org/10.1016/0014-5793(92)80106-Q DOI 10.1016/0378-1119(89)90524-6 http://dx.doi.org/10.1016/0378-1119(89)90524-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1432-1033.1992.tb17315.x http://dx.doi.org/10.1111/j.1432-1033.1992.tb17315.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.1.1.22 http://www.genome.jp/dbget-bin/www_bget?EC:6.1.1.22 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M33145 http://www.ebi.ac.uk/ena/data/view/M33145 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X68192 http://www.ebi.ac.uk/ena/data/view/X68192 ENZYME 6.1.1.22 http://enzyme.expasy.org/EC/6.1.1.22 EchoBASE EB0092 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0092 EcoGene EG10094 http://www.ecogene.org/geneInfo.php?eg_id=EG10094 EnsemblBacteria AAC74016 http://www.ensemblgenomes.org/id/AAC74016 EnsemblBacteria AAC74016 http://www.ensemblgenomes.org/id/AAC74016 EnsemblBacteria BAA35682 http://www.ensemblgenomes.org/id/BAA35682 EnsemblBacteria BAA35682 http://www.ensemblgenomes.org/id/BAA35682 EnsemblBacteria BAA35682 http://www.ensemblgenomes.org/id/BAA35682 EnsemblBacteria b0930 http://www.ensemblgenomes.org/id/b0930 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003676 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003676 GO_function GO:0004816 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004816 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006418 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006418 GO_process GO:0006421 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006421 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GeneID 945555 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945555 HAMAP MF_00534 http://hamap.expasy.org/unirule/MF_00534 HOGENOM HOG000226033 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000226033&db=HOGENOM6 InParanoid P0A8M0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8M0 IntAct P0A8M0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8M0* IntEnz 6.1.1.22 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.1.1.22 InterPro IPR002312 http://www.ebi.ac.uk/interpro/entry/IPR002312 InterPro IPR004364 http://www.ebi.ac.uk/interpro/entry/IPR004364 InterPro IPR004365 http://www.ebi.ac.uk/interpro/entry/IPR004365 InterPro IPR004522 http://www.ebi.ac.uk/interpro/entry/IPR004522 InterPro IPR006195 http://www.ebi.ac.uk/interpro/entry/IPR006195 InterPro IPR012340 http://www.ebi.ac.uk/interpro/entry/IPR012340 InterPro IPR018150 http://www.ebi.ac.uk/interpro/entry/IPR018150 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW0913 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0913 KEGG_Gene eco:b0930 http://www.genome.jp/dbget-bin/www_bget?eco:b0930 KEGG_Orthology KO:K01893 http://www.genome.jp/dbget-bin/www_bget?KO:K01893 KEGG_Pathway ko00970 http://www.genome.jp/kegg-bin/show_pathway?ko00970 KEGG_Reaction rn:R03648 http://www.genome.jp/dbget-bin/www_bget?rn:R03648 MINT MINT-1319001 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1319001 OMA PEDMEFF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PEDMEFF PANTHER PTHR22594 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22594 PANTHER PTHR22594:SF6 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22594:SF6 PRINTS PR01042 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01042 PROSITE PS50862 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50862 PSORT swissprot:SYN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SYN_ECOLI PSORT-B swissprot:SYN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SYN_ECOLI PSORT2 swissprot:SYN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SYN_ECOLI Pfam PF00152 http://pfam.xfam.org/family/PF00152 Pfam PF01336 http://pfam.xfam.org/family/PF01336 Phobius swissprot:SYN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SYN_ECOLI PhylomeDB P0A8M0 http://phylomedb.org/?seqid=P0A8M0 ProteinModelPortal P0A8M0 http://www.proteinmodelportal.org/query/uniprot/P0A8M0 PubMed 1425658 http://www.ncbi.nlm.nih.gov/pubmed/1425658 PubMed 1544480 http://www.ncbi.nlm.nih.gov/pubmed/1544480 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2009959 http://www.ncbi.nlm.nih.gov/pubmed/2009959 PubMed 2693216 http://www.ncbi.nlm.nih.gov/pubmed/2693216 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_415450 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415450 RefSeq WP_000117881 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000117881 SMR P0A8M0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8M0 STRING 511145.b0930 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0930&targetmode=cogs STRING COG0017 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0017&targetmode=cogs SUPFAM SSF50249 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50249 SWISS-2DPAGE P0A8M0 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A8M0 TIGRFAMs TIGR00457 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00457 UniProtKB SYN_ECOLI http://www.uniprot.org/uniprot/SYN_ECOLI UniProtKB-AC P0A8M0 http://www.uniprot.org/uniprot/P0A8M0 charge swissprot:SYN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SYN_ECOLI eggNOG COG0017 http://eggnogapi.embl.de/nog_data/html/tree/COG0017 eggNOG ENOG4105C5S http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C5S epestfind swissprot:SYN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SYN_ECOLI garnier swissprot:SYN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SYN_ECOLI helixturnhelix swissprot:SYN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SYN_ECOLI hmoment swissprot:SYN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SYN_ECOLI iep swissprot:SYN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SYN_ECOLI inforesidue swissprot:SYN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SYN_ECOLI octanol swissprot:SYN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SYN_ECOLI pepcoil swissprot:SYN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SYN_ECOLI pepdigest swissprot:SYN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SYN_ECOLI pepinfo swissprot:SYN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SYN_ECOLI pepnet swissprot:SYN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SYN_ECOLI pepstats swissprot:SYN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SYN_ECOLI pepwheel swissprot:SYN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SYN_ECOLI pepwindow swissprot:SYN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SYN_ECOLI sigcleave swissprot:SYN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SYN_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters KM=0.15 uM for tRNA(Asp); KM=3000 uM for glutamate; # BRENDA 6.1.1.B3 2026 # BioGrid 4259736 6 # COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI 29105; Note=Binds 1 zinc ion per subunit.; # EcoGene EG11362 gluQ # FUNCTION GLUQ_ECOLI Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in position 34 of the tRNA(Asp), the wobble position of the QUC anticodon. Does not transfer glutamate to either tRNA(Glu) or tRNA(Gln). The incapacity of the glutamylated tRNA(Asp) to bind elongation factor Tu suggests that it is not involved in ribosomal protein biosynthesis. {ECO 0000269|PubMed 15096594, ECO 0000269|PubMed 15096612, ECO 0000269|PubMed 15150343}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0003723 RNA binding; IBA:GO_Central. # GO_function GO:0004818 glutamate-tRNA ligase activity; IBA:GO_Central. # GO_function GO:0005524 ATP binding; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_process GO:0002097 tRNA wobble base modification; IDA:EcoCyc. # GO_process GO:0006424 glutamyl-tRNA aminoacylation; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0006520 cellular amino acid metabolic process # Gene3D 3.40.50.620 -; 2. # HAMAP MF_01428 Glu_Q_tRNA_synth # InterPro IPR000924 Glu/Gln-tRNA-synth # InterPro IPR014729 Rossmann-like_a/b/a_fold # InterPro IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom # InterPro IPR022380 Glu-Q_TRNA(Asp)_Synthase # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01007 Amino acid related enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # Organism GLUQ_ECOLI Escherichia coli (strain K12) # PATRIC 32115395 VBIEscCol129921_0149 # PDB 1NZJ X-ray; 1.50 A; A=11-308 # PDB 4A91 X-ray; 1.75 A; A=11-308 # PIR H64737 H64737 # PRINTS PR00987 TRNASYNTHGLU # Pfam PF00749 tRNA-synt_1c # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLUQ_ECOLI Glutamyl-Q tRNA(Asp) synthetase # RefSeq NP_414686 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA23686.1; Type=Frameshift; Positions=Several; Evidence={ECO 0000305}; # SIMILARITY Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily. {ECO 0000305}. # TIGRFAMs TIGR03838 queuosine_YadB # eggNOG COG0008 LUCA # eggNOG ENOG4106F3G Bacteria BLAST swissprot:GLUQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLUQ_ECOLI BioCyc ECOL316407:JW5892-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5892-MONOMER BioCyc EcoCyc:EG11362-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11362-MONOMER BioCyc MetaCyc:EG11362-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11362-MONOMER DIP DIP-11180N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11180N DOI 10.1016/j.jmb.2004.01.027 http://dx.doi.org/10.1016/j.jmb.2004.01.027 DOI 10.1016/j.jmb.2008.06.053 http://dx.doi.org/10.1016/j.jmb.2008.06.053 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0401634101 http://dx.doi.org/10.1073/pnas.0401634101 DOI 10.1073/pnas.0401982101 http://dx.doi.org/10.1073/pnas.0401982101 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1093/nar/gkh608 http://dx.doi.org/10.1093/nar/gkh608 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.1.1.- http://www.genome.jp/dbget-bin/www_bget?EC:6.1.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M34945 http://www.ebi.ac.uk/ena/data/view/M34945 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X64595 http://www.ebi.ac.uk/ena/data/view/X64595 ENZYME 6.1.1.- http://enzyme.expasy.org/EC/6.1.1.- EchoBASE EB1337 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1337 EcoGene EG11362 http://www.ecogene.org/geneInfo.php?eg_id=EG11362 EnsemblBacteria AAC73255 http://www.ensemblgenomes.org/id/AAC73255 EnsemblBacteria AAC73255 http://www.ensemblgenomes.org/id/AAC73255 EnsemblBacteria BAB96721 http://www.ensemblgenomes.org/id/BAB96721 EnsemblBacteria BAB96721 http://www.ensemblgenomes.org/id/BAB96721 EnsemblBacteria BAB96721 http://www.ensemblgenomes.org/id/BAB96721 EnsemblBacteria b0144 http://www.ensemblgenomes.org/id/b0144 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0004818 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004818 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_process GO:0002097 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002097 GO_process GO:0006424 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006424 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 GeneID 944846 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944846 HAMAP MF_01428 http://hamap.expasy.org/unirule/MF_01428 HOGENOM HOG000252723 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000252723&db=HOGENOM6 InParanoid P27305 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P27305 IntEnz 6.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.1.1 InterPro IPR000924 http://www.ebi.ac.uk/interpro/entry/IPR000924 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 InterPro IPR020058 http://www.ebi.ac.uk/interpro/entry/IPR020058 InterPro IPR022380 http://www.ebi.ac.uk/interpro/entry/IPR022380 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW5892 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5892 KEGG_Gene eco:b0144 http://www.genome.jp/dbget-bin/www_bget?eco:b0144 KEGG_Orthology KO:K01894 http://www.genome.jp/dbget-bin/www_bget?KO:K01894 MINT MINT-1218773 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1218773 PDB 1NZJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1NZJ PDB 4A91 http://www.ebi.ac.uk/pdbe-srv/view/entry/4A91 PDBsum 1NZJ http://www.ebi.ac.uk/pdbsum/1NZJ PDBsum 4A91 http://www.ebi.ac.uk/pdbsum/4A91 PRINTS PR00987 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00987 PSORT swissprot:GLUQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLUQ_ECOLI PSORT-B swissprot:GLUQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLUQ_ECOLI PSORT2 swissprot:GLUQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLUQ_ECOLI Pfam PF00749 http://pfam.xfam.org/family/PF00749 Phobius swissprot:GLUQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLUQ_ECOLI PhylomeDB P27305 http://phylomedb.org/?seqid=P27305 ProteinModelPortal P27305 http://www.proteinmodelportal.org/query/uniprot/P27305 PubMed 15003446 http://www.ncbi.nlm.nih.gov/pubmed/15003446 PubMed 15096594 http://www.ncbi.nlm.nih.gov/pubmed/15096594 PubMed 15096612 http://www.ncbi.nlm.nih.gov/pubmed/15096612 PubMed 15150343 http://www.ncbi.nlm.nih.gov/pubmed/15150343 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18602926 http://www.ncbi.nlm.nih.gov/pubmed/18602926 PubMed 2180916 http://www.ncbi.nlm.nih.gov/pubmed/2180916 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414686 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414686 SMR P27305 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P27305 STRING 511145.b0144 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0144&targetmode=cogs TIGRFAMs TIGR03838 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03838 UniProtKB GLUQ_ECOLI http://www.uniprot.org/uniprot/GLUQ_ECOLI UniProtKB-AC P27305 http://www.uniprot.org/uniprot/P27305 charge swissprot:GLUQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLUQ_ECOLI eggNOG COG0008 http://eggnogapi.embl.de/nog_data/html/tree/COG0008 eggNOG ENOG4106F3G http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106F3G epestfind swissprot:GLUQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLUQ_ECOLI garnier swissprot:GLUQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLUQ_ECOLI helixturnhelix swissprot:GLUQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLUQ_ECOLI hmoment swissprot:GLUQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLUQ_ECOLI iep swissprot:GLUQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLUQ_ECOLI inforesidue swissprot:GLUQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLUQ_ECOLI octanol swissprot:GLUQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLUQ_ECOLI pepcoil swissprot:GLUQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLUQ_ECOLI pepdigest swissprot:GLUQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLUQ_ECOLI pepinfo swissprot:GLUQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLUQ_ECOLI pepnet swissprot:GLUQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLUQ_ECOLI pepstats swissprot:GLUQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLUQ_ECOLI pepwheel swissprot:GLUQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLUQ_ECOLI pepwindow swissprot:GLUQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLUQ_ECOLI sigcleave swissprot:GLUQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLUQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4263538 13 # EcoGene EG10353 fucR # FUNCTION FUCR_ECOLI Transcriptional activator of the fuc operon. # GO_component GO:0005622 intracellular; IEA:InterPro. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006004 fucose metabolic process; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_component GO:0005622 intracellular # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.10.10 -; 1. # IntAct P0ACK8 5 # InterPro IPR001034 DeoR_HTH # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR014036 DeoR_C # InterPro IPR018356 Tscrpt_reg_HTH_DeoR_CS # KEGG_Brite ko03000 Transcription factors # Organism FUCR_ECOLI Escherichia coli (strain K12) # PATRIC 32121026 VBIEscCol129921_2905 # PIR JS0188 RGECFO # PRINTS PR00037 HTHLACR # PROSITE PS00894 HTH_DEOR_1 # PROSITE PS51000 HTH_DEOR_2 # Pfam PF00455 DeoRC # Pfam PF08220 HTH_DeoR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FUCR_ECOLI L-fucose operon activator # RefSeq NP_417285 NC_000913.3 # RefSeq WP_000642344 NZ_LN832404.1 # SIMILARITY Contains 1 HTH deoR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00349}. # SMART SM00420 HTH_DEOR # SUPFAM SSF46785 SSF46785 # eggNOG COG1349 LUCA # eggNOG ENOG4107EDW Bacteria BLAST swissprot:FUCR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FUCR_ECOLI BioCyc ECOL316407:JW2776-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2776-MONOMER BioCyc EcoCyc:PD00444 http://biocyc.org/getid?id=EcoCyc:PD00444 COG COG1349 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1349 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/17.12.4883 http://dx.doi.org/10.1093/nar/17.12.4883 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 EMBL X15025 http://www.ebi.ac.uk/ena/data/view/X15025 EchoBASE EB0349 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0349 EcoGene EG10353 http://www.ecogene.org/geneInfo.php?eg_id=EG10353 EnsemblBacteria AAC75847 http://www.ensemblgenomes.org/id/AAC75847 EnsemblBacteria AAC75847 http://www.ensemblgenomes.org/id/AAC75847 EnsemblBacteria BAE76877 http://www.ensemblgenomes.org/id/BAE76877 EnsemblBacteria BAE76877 http://www.ensemblgenomes.org/id/BAE76877 EnsemblBacteria BAE76877 http://www.ensemblgenomes.org/id/BAE76877 EnsemblBacteria b2805 http://www.ensemblgenomes.org/id/b2805 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006004 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006004 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 946905 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946905 HOGENOM HOG000224683 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000224683&db=HOGENOM6 IntAct P0ACK8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACK8* InterPro IPR001034 http://www.ebi.ac.uk/interpro/entry/IPR001034 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR014036 http://www.ebi.ac.uk/interpro/entry/IPR014036 InterPro IPR018356 http://www.ebi.ac.uk/interpro/entry/IPR018356 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW2776 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2776 KEGG_Gene eco:b2805 http://www.genome.jp/dbget-bin/www_bget?eco:b2805 KEGG_Orthology KO:K02430 http://www.genome.jp/dbget-bin/www_bget?KO:K02430 OMA PICHEMA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PICHEMA PRINTS PR00037 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00037 PROSITE PS00894 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00894 PROSITE PS51000 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51000 PSORT swissprot:FUCR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FUCR_ECOLI PSORT-B swissprot:FUCR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FUCR_ECOLI PSORT2 swissprot:FUCR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FUCR_ECOLI Pfam PF00455 http://pfam.xfam.org/family/PF00455 Pfam PF08220 http://pfam.xfam.org/family/PF08220 Phobius swissprot:FUCR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FUCR_ECOLI PhylomeDB P0ACK8 http://phylomedb.org/?seqid=P0ACK8 ProteinModelPortal P0ACK8 http://www.proteinmodelportal.org/query/uniprot/P0ACK8 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2664711 http://www.ncbi.nlm.nih.gov/pubmed/2664711 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417285 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417285 RefSeq WP_000642344 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000642344 SMART SM00420 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00420 STRING 511145.b2805 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2805&targetmode=cogs STRING COG1349 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1349&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB FUCR_ECOLI http://www.uniprot.org/uniprot/FUCR_ECOLI UniProtKB-AC P0ACK8 http://www.uniprot.org/uniprot/P0ACK8 charge swissprot:FUCR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FUCR_ECOLI eggNOG COG1349 http://eggnogapi.embl.de/nog_data/html/tree/COG1349 eggNOG ENOG4107EDW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107EDW epestfind swissprot:FUCR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FUCR_ECOLI garnier swissprot:FUCR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FUCR_ECOLI helixturnhelix swissprot:FUCR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FUCR_ECOLI hmoment swissprot:FUCR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FUCR_ECOLI iep swissprot:FUCR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FUCR_ECOLI inforesidue swissprot:FUCR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FUCR_ECOLI octanol swissprot:FUCR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FUCR_ECOLI pepcoil swissprot:FUCR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FUCR_ECOLI pepdigest swissprot:FUCR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FUCR_ECOLI pepinfo swissprot:FUCR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FUCR_ECOLI pepnet swissprot:FUCR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FUCR_ECOLI pepstats swissprot:FUCR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FUCR_ECOLI pepwheel swissprot:FUCR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FUCR_ECOLI pepwindow swissprot:FUCR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FUCR_ECOLI sigcleave swissprot:FUCR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FUCR_ECOLI ## Database ID URL or Descriptions # BioGrid 4262391 17 # CDD cd00383 trans_reg_C # EcoGene EG13026 qseB # FUNCTION QSEB_ECOLI Member of a two-component regulatory system QseB/QseC. Activates the flagella regulon by activating transcription of FlhDC. Currently it is not known whether this effect is direct or not. {ECO 0000269|PubMed 11929534}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0000156 phosphorelay response regulator activity; IMP:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; EXP:EcoCyc. # GO_process GO:0009372 quorum sensing; IMP:EcoCyc. # GO_process GO:0010038 response to metal ion; IMP:EcoCyc. # GO_process GO:0010628 positive regulation of gene expression; IDA:EcoCyc. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; EXP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004871 signal transducer activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0042592 homeostatic process # Gene3D 1.10.10.10 -; 1. # INDUCTION By the signal autoinducer AI-2, through MqsR. {ECO:0000269|PubMed 16352847}. # IntAct P52076 5 # InterPro IPR001789 Sig_transdc_resp-reg_receiver # InterPro IPR001867 OmpR/PhoB-type_DNA-bd # InterPro IPR011006 CheY-like_superfamily # InterPro IPR011991 WHTH_DNA-bd_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02022 M00453 QseC-QseB (quorum sensing) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # Organism QSEB_ECOLI Escherichia coli (strain K12) # PATRIC 32121462 VBIEscCol129921_3118 # PIR G65089 G65089 # PROSITE PS50110 RESPONSE_REGULATORY # PROSITE PS51755 OMPR_PHOB # PTM QSEB_ECOLI Phosphorylated by QseC. {ECO 0000305}. # Pfam PF00072 Response_reg # Pfam PF00486 Trans_reg_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName QSEB_ECOLI Transcriptional regulatory protein QseB # RefSeq NP_417497 NC_000913.3 # RefSeq WP_001221495 NZ_LN832404.1 # SIMILARITY Contains 1 OmpR/PhoB-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU01091}. # SIMILARITY Contains 1 response regulatory domain. {ECO:0000255|PROSITE-ProRule PRU00169}. # SMART SM00448 REC # SMART SM00862 Trans_reg_C # SUBCELLULAR LOCATION QSEB_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF52172 SSF52172 # eggNOG ENOG4105XJC Bacteria # eggNOG ENOG4111FPD LUCA BLAST swissprot:QSEB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:QSEB_ECOLI BioCyc ECOL316407:JW2993-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2993-MONOMER BioCyc EcoCyc:G7575-MONOMER http://biocyc.org/getid?id=EcoCyc:G7575-MONOMER COG COG0745 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0745 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2002.02803.x http://dx.doi.org/10.1046/j.1365-2958.2002.02803.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.188.1.305-316.2006 http://dx.doi.org/10.1128/JB.188.1.305-316.2006 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2844 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2844 EcoGene EG13026 http://www.ecogene.org/geneInfo.php?eg_id=EG13026 EnsemblBacteria AAC76061 http://www.ensemblgenomes.org/id/AAC76061 EnsemblBacteria AAC76061 http://www.ensemblgenomes.org/id/AAC76061 EnsemblBacteria BAE77081 http://www.ensemblgenomes.org/id/BAE77081 EnsemblBacteria BAE77081 http://www.ensemblgenomes.org/id/BAE77081 EnsemblBacteria BAE77081 http://www.ensemblgenomes.org/id/BAE77081 EnsemblBacteria b3025 http://www.ensemblgenomes.org/id/b3025 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000156 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000156 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0009372 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009372 GO_process GO:0010038 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010038 GO_process GO:0010628 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010628 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 945369 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945369 HOGENOM HOG000034815 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000034815&db=HOGENOM6 InParanoid P52076 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P52076 IntAct P52076 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P52076* InterPro IPR001789 http://www.ebi.ac.uk/interpro/entry/IPR001789 InterPro IPR001867 http://www.ebi.ac.uk/interpro/entry/IPR001867 InterPro IPR011006 http://www.ebi.ac.uk/interpro/entry/IPR011006 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW2993 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2993 KEGG_Gene eco:b3025 http://www.genome.jp/dbget-bin/www_bget?eco:b3025 KEGG_Orthology KO:K07666 http://www.genome.jp/dbget-bin/www_bget?KO:K07666 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA LGYMIAK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LGYMIAK PROSITE PS50110 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50110 PROSITE PS51755 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51755 PSORT swissprot:QSEB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:QSEB_ECOLI PSORT-B swissprot:QSEB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:QSEB_ECOLI PSORT2 swissprot:QSEB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:QSEB_ECOLI Pfam PF00072 http://pfam.xfam.org/family/PF00072 Pfam PF00486 http://pfam.xfam.org/family/PF00486 Phobius swissprot:QSEB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:QSEB_ECOLI PhylomeDB P52076 http://phylomedb.org/?seqid=P52076 ProteinModelPortal P52076 http://www.proteinmodelportal.org/query/uniprot/P52076 PubMed 11929534 http://www.ncbi.nlm.nih.gov/pubmed/11929534 PubMed 16352847 http://www.ncbi.nlm.nih.gov/pubmed/16352847 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417497 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417497 RefSeq WP_001221495 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001221495 SMART SM00448 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00448 SMART SM00862 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00862 SMR P52076 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P52076 STRING 511145.b3025 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3025&targetmode=cogs STRING COG0745 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0745&targetmode=cogs SUPFAM SSF52172 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52172 UniProtKB QSEB_ECOLI http://www.uniprot.org/uniprot/QSEB_ECOLI UniProtKB-AC P52076 http://www.uniprot.org/uniprot/P52076 charge swissprot:QSEB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:QSEB_ECOLI eggNOG ENOG4105XJC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105XJC eggNOG ENOG4111FPD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111FPD epestfind swissprot:QSEB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:QSEB_ECOLI garnier swissprot:QSEB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:QSEB_ECOLI helixturnhelix swissprot:QSEB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:QSEB_ECOLI hmoment swissprot:QSEB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:QSEB_ECOLI iep swissprot:QSEB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:QSEB_ECOLI inforesidue swissprot:QSEB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:QSEB_ECOLI octanol swissprot:QSEB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:QSEB_ECOLI pepcoil swissprot:QSEB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:QSEB_ECOLI pepdigest swissprot:QSEB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:QSEB_ECOLI pepinfo swissprot:QSEB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:QSEB_ECOLI pepnet swissprot:QSEB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:QSEB_ECOLI pepstats swissprot:QSEB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:QSEB_ECOLI pepwheel swissprot:QSEB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:QSEB_ECOLI pepwindow swissprot:QSEB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:QSEB_ECOLI sigcleave swissprot:QSEB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:QSEB_ECOLI ## Database ID URL or Descriptions # BioGrid 4263298 154 # EcoGene EG11424 rfaL # FUNCTION RFAL_ECOLI Adds the O-antigen on the glucose group of LPS. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0016874 ligase activity; IEA:UniProtKB-KW. # GO_process GO:0009244 lipopolysaccharide core region biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016874 ligase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # InterPro IPR007016 O-antigen_ligase-related # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # KEGG_Pathway ko00540 Lipopolysaccharide biosynthesis # Organism RFAL_ECOLI Escherichia coli (strain K12) # PATHWAY RFAL_ECOLI Bacterial outer membrane biogenesis; LPS core biosynthesis. # PATRIC 32122731 VBIEscCol129921_3742 # PIR S47843 S47843 # Pfam PF04932 Wzy_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RFAL_ECOLI O-antigen ligase # RefSeq NP_418079 NC_000913.3 # RefSeq WP_001395405 NZ_LN832404.1 # SUBCELLULAR LOCATION RFAL_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 9.B.67.5 the putative inorganic carbon (hco3(-)) transporter/o-antigen polymerase (ict/oap) family # eggNOG ENOG41068PG Bacteria # eggNOG ENOG410XW26 LUCA BLAST swissprot:RFAL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RFAL_ECOLI BioCyc ECOL316407:JW3597-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3597-MONOMER BioCyc EcoCyc:EG11424-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11424-MONOMER BioCyc MetaCyc:EG11424-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11424-MONOMER COG COG3307 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3307 DIP DIP-10673N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10673N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M95398 http://www.ebi.ac.uk/ena/data/view/M95398 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1394 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1394 EcoGene EG11424 http://www.ecogene.org/geneInfo.php?eg_id=EG11424 EnsemblBacteria AAC76646 http://www.ensemblgenomes.org/id/AAC76646 EnsemblBacteria AAC76646 http://www.ensemblgenomes.org/id/AAC76646 EnsemblBacteria BAE77670 http://www.ensemblgenomes.org/id/BAE77670 EnsemblBacteria BAE77670 http://www.ensemblgenomes.org/id/BAE77670 EnsemblBacteria BAE77670 http://www.ensemblgenomes.org/id/BAE77670 EnsemblBacteria b3622 http://www.ensemblgenomes.org/id/b3622 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GO_process GO:0009244 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009244 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 948148 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948148 HOGENOM HOG000054845 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000054845&db=HOGENOM6 IntAct P27243 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P27243* InterPro IPR007016 http://www.ebi.ac.uk/interpro/entry/IPR007016 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Gene ecj:JW3597 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3597 KEGG_Gene eco:b3622 http://www.genome.jp/dbget-bin/www_bget?eco:b3622 KEGG_Orthology KO:K02847 http://www.genome.jp/dbget-bin/www_bget?KO:K02847 KEGG_Pathway ko00540 http://www.genome.jp/kegg-bin/show_pathway?ko00540 MINT MINT-1286025 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1286025 OMA MLNELRY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MLNELRY PSORT swissprot:RFAL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RFAL_ECOLI PSORT-B swissprot:RFAL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RFAL_ECOLI PSORT2 swissprot:RFAL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RFAL_ECOLI Pfam PF04932 http://pfam.xfam.org/family/PF04932 Phobius swissprot:RFAL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RFAL_ECOLI ProteinModelPortal P27243 http://www.proteinmodelportal.org/query/uniprot/P27243 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 1624462 http://www.ncbi.nlm.nih.gov/pubmed/1624462 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418079 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418079 RefSeq WP_001395405 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001395405 STRING 511145.b3622 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3622&targetmode=cogs STRING COG3307 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3307&targetmode=cogs TCDB 9.B.67.5 http://www.tcdb.org/search/result.php?tc=9.B.67.5 UniProtKB RFAL_ECOLI http://www.uniprot.org/uniprot/RFAL_ECOLI UniProtKB-AC P27243 http://www.uniprot.org/uniprot/P27243 charge swissprot:RFAL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RFAL_ECOLI eggNOG ENOG41068PG http://eggnogapi.embl.de/nog_data/html/tree/ENOG41068PG eggNOG ENOG410XW26 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XW26 epestfind swissprot:RFAL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RFAL_ECOLI garnier swissprot:RFAL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RFAL_ECOLI helixturnhelix swissprot:RFAL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RFAL_ECOLI hmoment swissprot:RFAL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RFAL_ECOLI iep swissprot:RFAL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RFAL_ECOLI inforesidue swissprot:RFAL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RFAL_ECOLI octanol swissprot:RFAL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RFAL_ECOLI pepcoil swissprot:RFAL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RFAL_ECOLI pepdigest swissprot:RFAL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RFAL_ECOLI pepinfo swissprot:RFAL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RFAL_ECOLI pepnet swissprot:RFAL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RFAL_ECOLI pepstats swissprot:RFAL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RFAL_ECOLI pepwheel swissprot:RFAL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RFAL_ECOLI pepwindow swissprot:RFAL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RFAL_ECOLI sigcleave swissprot:RFAL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RFAL_ECOLI ## Database ID URL or Descriptions # AltName XAPA_ECOLI Inosine-guanosine phosphorylase # AltName XAPA_ECOLI Purine nucleoside phosphorylase II # AltName XAPA_ECOLI Xanthosine phosphorylase # BIOPHYSICOCHEMICAL PROPERTIES XAPA_ECOLI Kinetic parameters KM=51 uM for xanthosine (at pH 7.0, PubMed 3042752) {ECO 0000269|PubMed 15808857, ECO 0000269|PubMed 3042752}; KM=72 uM for xanthosine (at 25 degrees Celsius and pH 7.1, PubMed 15808857) {ECO 0000269|PubMed 15808857, ECO 0000269|PubMed 3042752}; KM=110 uM for guanosine (at pH 7.0, PubMed 3042752) {ECO 0000269|PubMed 15808857, ECO 0000269|PubMed 3042752}; KM=155 uM for guanosine (at 25 degrees Celsius and pH 7.1, PubMed 15808857) {ECO 0000269|PubMed 15808857, ECO 0000269|PubMed 3042752}; KM=963 uM for inosine (at 25 degrees Celsius and pH 7.1, PubMed 15808857) {ECO 0000269|PubMed 15808857, ECO 0000269|PubMed 3042752}; KM=340 uM for inosine (at 25 degrees Celsius and pH 7.0, PubMed 3042752) {ECO 0000269|PubMed 15808857, ECO 0000269|PubMed 3042752}; KM=62 uM for 2'-deoxyinosine (at 25 degrees Celsius and pH 7.0) {ECO 0000269|PubMed 15808857, ECO 0000269|PubMed 3042752}; KM=600 uM for 5'-deoxyinosine (at 25 degrees Celsius and pH 7.0) {ECO 0000269|PubMed 15808857, ECO 0000269|PubMed 3042752}; KM=2600 uM for 2',3'-dideoxyinosine (at 25 degrees Celsius and pH 7.0) {ECO 0000269|PubMed 15808857, ECO 0000269|PubMed 3042752}; KM=44 uM for 2'-deoxyguanosine (at 25 degrees Celsius and pH 7.0) {ECO 0000269|PubMed 15808857, ECO 0000269|PubMed 3042752}; KM=3.3 uM for hypoxanthine (at 25 degrees Celsius and pH 7.0) {ECO 0000269|PubMed 15808857, ECO 0000269|PubMed 3042752}; KM=4.1 uM for guanine (at 25 degrees Celsius and pH 7.0) {ECO 0000269|PubMed 15808857, ECO 0000269|PubMed 3042752}; KM=760 uM for phosphate (at 25 degrees Celsius and pH 7.0) {ECO 0000269|PubMed 15808857, ECO 0000269|PubMed 3042752}; KM=59 uM for alpha-D-ribose 1-phosphate (at 25 degrees Celsius and pH 7.0) {ECO 0000269|PubMed 15808857, ECO 0000269|PubMed 3042752}; KM=58 uM for alpha-D-2'-deoxyribose 1-phosphate (at 25 degrees Celsius and pH 7.0) {ECO 0000269|PubMed 15808857, ECO 0000269|PubMed 3042752}; Vmax=8.7 umol/min/mg enzyme with xanthosine as substrate (at 25 degrees Celsius and pH 7.1, PubMed 15808857) {ECO 0000269|PubMed 15808857, ECO 0000269|PubMed 3042752}; Vmax=14.2 umol/min/mg enzyme with guanosine as substrate (at 25 degrees Celsius and pH 7.1, PubMed 15808857) {ECO 0000269|PubMed 15808857, ECO 0000269|PubMed 3042752}; Vmax=11.9 umol/min/mg enzyme with inosine as substrate (at 25 degrees Celsius and pH 7.1, PubMed 15808857) {ECO 0000269|PubMed 15808857, ECO 0000269|PubMed 3042752}; pH dependence Optimum pH is 6.5-7.5 with guanosine as substrate. At pH higher than 7.5, there is a marked reduction in reaction rate and a steep drop at pH higher than 9. Below pH 6.5, there is a dramatic decrease in activity reaching virtually zero at pH 6.0. With xanthosine as substrate, the pH optimum is 5.8-7.2. In the reverse reaction with guanine or xanthine as substrates, the pH optimum is 6.5-8.0. The pH dependence of inosine cleavage does not vary between pH 6 and 8. Maximal activity with inosine as substrate is observed at pH 6.6. {ECO 0000269|PubMed 15808857, ECO 0000269|PubMed 3042752}; Temperature dependence The half-life at 45 degrees Celsius between pH 5 and 8 is 5 to 9 minutes. {ECO 0000269|PubMed 15808857, ECO 0000269|PubMed 3042752}; # BRENDA 2.4.2 2026 # BioGrid 4260565 16 # CATALYTIC ACTIVITY XAPA_ECOLI Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate. {ECO 0000269|PubMed 10400599, ECO 0000269|PubMed 15808857, ECO 0000269|PubMed 17151449, ECO 0000269|PubMed 3042752, ECO 0000269|PubMed 7007809, ECO 0000269|PubMed 7559336}. # DISRUPTION PHENOTYPE XAPA_ECOLI Does not grow on xanthosine. Slightly increases inosine productivity compared to wild-type (5.6 g/l of inosine versus 4.6 g/l, respectively, from 40 g/l of glucose). {ECO 0000269|PubMed 17151449, ECO 0000269|PubMed 7559336}. # ENZYME REGULATION Rapidly inactivated by p- chloromercuriphenylsulfonic acid (p-CMB). Dithiothreitol incubation restores the activity. {ECO:0000269|PubMed 3042752}. # EcoGene EG20250 xapA # FUNCTION XAPA_ECOLI The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. This protein can degrade all purine nucleosides including xanthosine, inosine and guanosine, but cannot cleave adenosine, deoxyadenosine or hypoxanthine arabinoside. Has a preference for the neutral over the monoanionic form of xanthosine. {ECO 0000269|PubMed 15808857, ECO 0000269|PubMed 3042752, ECO 0000269|PubMed 7007808, ECO 0000269|PubMed 7007809}. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_function GO:0004731 purine-nucleoside phosphorylase activity; IDA:UniProtKB. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0047724 inosine nucleosidase activity; IDA:UniProtKB. # GO_function GO:0047975 guanosine phosphorylase activity; IDA:UniProtKB. # GO_process GO:0006148 inosine catabolic process; IDA:UniProtKB. # GO_process GO:0006149 deoxyinosine catabolic process; IDA:UniProtKB. # GO_process GO:0006152 purine nucleoside catabolic process; IDA:UniProtKB. # GO_process GO:0006161 deoxyguanosine catabolic process; IDA:UniProtKB. # GO_process GO:0015949 nucleobase-containing small molecule interconversion; IMP:EcoliWiki. # GO_process GO:0034214 protein hexamerization; IDA:UniProtKB. # GO_process GO:0043101 purine-containing compound salvage; IBA:GO_Central. # GO_process GO:0046115 guanosine catabolic process; IDA:UniProtKB. # GO_process GO:0055086 nucleobase-containing small molecule metabolic process; IMP:EcoliWiki. # GO_process GO:1903228 xanthosine catabolic process; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.1580 -; 1. # INDUCTION XAPA_ECOLI By xanthosine and to a lesser extent by deoxyinosine. Full expression requires XapR-xanthosine DNA-binding transcriptional activator. {ECO 0000269|PubMed 10400599, ECO 0000269|PubMed 7007809, ECO 0000269|PubMed 7559336}. # IntAct P45563 4 # InterPro IPR000845 Nucleoside_phosphorylase_d # InterPro IPR001369 PNP/MTAP # InterPro IPR010943 Xanthosine_phosphorylase # InterPro IPR011268 Purine_phosphorylase # InterPro IPR018099 Purine_phosphorylase-2_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # Organism XAPA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11904 PTHR11904 # PANTHER PTHR11904:SF9 PTHR11904:SF9 # PATHWAY XAPA_ECOLI Purine metabolism; purine nucleoside salvage. # PATHWAY XAPA_ECOLI Purine metabolism; xanthosine degradation. # PATRIC 32120195 VBIEscCol129921_2500 # PDB 1YQQ X-ray; 2.60 A; A/B/C=1-277 # PDB 1YQU X-ray; 3.10 A; A/B/C=1-277 # PDB 1YR3 X-ray; 3.20 A; A/B/C/D/E/F=1-277 # PIR F65014 F65014 # PIRSF PIRSF000477 PurNPase # PROSITE PS01240 PNP_MTAP_2 # Pfam PF01048 PNP_UDP_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName XAPA_ECOLI Purine nucleoside phosphorylase 2 # RefSeq NP_416902 NC_000913.3 # RefSeq WP_000084573 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA52049.1; Type=Frameshift; Positions=144, 177, 259, 261; Evidence={ECO 0000305}; # SIMILARITY Belongs to the PNP/MTAP phosphorylase family. {ECO 0000305}. # SUBUNIT XAPA_ECOLI Hexamer. Dimer of trimers. {ECO 0000269|PubMed 15808857, ECO 0000269|PubMed 7007809}. # SUPFAM SSF53167 SSF53167 # TIGRFAMs TIGR01697 PNPH-PUNA-XAPA # TIGRFAMs TIGR01699 XAPA # eggNOG COG0005 LUCA # eggNOG ENOG4107U5R Bacteria BLAST swissprot:XAPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:XAPA_ECOLI BioCyc ECOL316407:JW2398-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2398-MONOMER BioCyc EcoCyc:XANTHOSINEPHOSPHORY-MONOMER http://biocyc.org/getid?id=EcoCyc:XANTHOSINEPHOSPHORY-MONOMER BioCyc MetaCyc:XANTHOSINEPHOSPHORY-MONOMER http://biocyc.org/getid?id=MetaCyc:XANTHOSINEPHOSPHORY-MONOMER COG COG0005 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0005 DOI 10.1007/BF00425461 http://dx.doi.org/10.1007/BF00425461 DOI 10.1007/BF00425462 http://dx.doi.org/10.1007/BF00425462 DOI 10.1016/j.jmb.2005.02.019 http://dx.doi.org/10.1016/j.jmb.2005.02.019 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1271/bbb.60398 http://dx.doi.org/10.1271/bbb.60398 EC_number EC:2.4.2.1 {ECO:0000269|PubMed:10400599, ECO:0000269|PubMed:15808857, ECO:0000269|PubMed:17151449, ECO:0000269|PubMed:3042752, ECO:0000269|PubMed:7007809, ECO:0000269|PubMed:7559336} http://www.genome.jp/dbget-bin/www_bget?EC:2.4.2.1 {ECO:0000269|PubMed:10400599, ECO:0000269|PubMed:15808857, ECO:0000269|PubMed:17151449, ECO:0000269|PubMed:3042752, ECO:0000269|PubMed:7007809, ECO:0000269|PubMed:7559336} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X73828 http://www.ebi.ac.uk/ena/data/view/X73828 ENZYME 2.4.2.1 {ECO:0000269|PubMed:10400599, ECO:0000269|PubMed:15808857, ECO:0000269|PubMed:17151449, ECO:0000269|PubMed:3042752, ECO:0000269|PubMed:7007809, ECO:0000269|PubMed:7559336} http://enzyme.expasy.org/EC/2.4.2.1 {ECO:0000269|PubMed:10400599, ECO:0000269|PubMed:15808857, ECO:0000269|PubMed:17151449, ECO:0000269|PubMed:3042752, ECO:0000269|PubMed:7007809, ECO:0000269|PubMed:7559336} EchoBASE EB4152 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4152 EcoGene EG20250 http://www.ecogene.org/geneInfo.php?eg_id=EG20250 EnsemblBacteria AAC75460 http://www.ensemblgenomes.org/id/AAC75460 EnsemblBacteria AAC75460 http://www.ensemblgenomes.org/id/AAC75460 EnsemblBacteria BAA16275 http://www.ensemblgenomes.org/id/BAA16275 EnsemblBacteria BAA16275 http://www.ensemblgenomes.org/id/BAA16275 EnsemblBacteria BAA16275 http://www.ensemblgenomes.org/id/BAA16275 EnsemblBacteria b2407 http://www.ensemblgenomes.org/id/b2407 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004731 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004731 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0047724 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047724 GO_function GO:0047975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047975 GO_process GO:0006148 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006148 GO_process GO:0006149 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006149 GO_process GO:0006152 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006152 GO_process GO:0006161 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006161 GO_process GO:0015949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015949 GO_process GO:0034214 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034214 GO_process GO:0043101 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043101 GO_process GO:0046115 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046115 GO_process GO:0055086 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055086 GO_process GO:1903228 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903228 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.1580 http://www.cathdb.info/version/latest/superfamily/3.40.50.1580 GeneID 946878 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946878 HOGENOM HOG000045183 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000045183&db=HOGENOM6 InParanoid P45563 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45563 IntAct P45563 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45563* IntEnz 2.4.2.1 {ECO:0000269|PubMed:10400599, ECO:0000269|PubMed:15808857, ECO:0000269|PubMed:17151449, ECO:0000269|PubMed:3042752, ECO:0000269|PubMed:7007809, ECO:0000269|PubMed:7559336} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.2.1 {ECO:0000269|PubMed:10400599, ECO:0000269|PubMed:15808857, ECO:0000269|PubMed:17151449, ECO:0000269|PubMed:3042752, ECO:0000269|PubMed:7007809, ECO:0000269|PubMed:7559336} InterPro IPR000845 http://www.ebi.ac.uk/interpro/entry/IPR000845 InterPro IPR001369 http://www.ebi.ac.uk/interpro/entry/IPR001369 InterPro IPR010943 http://www.ebi.ac.uk/interpro/entry/IPR010943 InterPro IPR011268 http://www.ebi.ac.uk/interpro/entry/IPR011268 InterPro IPR018099 http://www.ebi.ac.uk/interpro/entry/IPR018099 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2398 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2398 KEGG_Gene eco:b2407 http://www.genome.jp/dbget-bin/www_bget?eco:b2407 KEGG_Orthology KO:K03815 http://www.genome.jp/dbget-bin/www_bget?KO:K03815 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Reaction rn:R02297 http://www.genome.jp/dbget-bin/www_bget?rn:R02297 OMA MENGYTY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MENGYTY PANTHER PTHR11904 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11904 PANTHER PTHR11904:SF9 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11904:SF9 PDB 1YQQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1YQQ PDB 1YQU http://www.ebi.ac.uk/pdbe-srv/view/entry/1YQU PDB 1YR3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1YR3 PDBsum 1YQQ http://www.ebi.ac.uk/pdbsum/1YQQ PDBsum 1YQU http://www.ebi.ac.uk/pdbsum/1YQU PDBsum 1YR3 http://www.ebi.ac.uk/pdbsum/1YR3 PROSITE PS01240 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01240 PSORT swissprot:XAPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:XAPA_ECOLI PSORT-B swissprot:XAPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:XAPA_ECOLI PSORT2 swissprot:XAPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:XAPA_ECOLI Pfam PF01048 http://pfam.xfam.org/family/PF01048 Phobius swissprot:XAPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:XAPA_ECOLI PhylomeDB P45563 http://phylomedb.org/?seqid=P45563 ProteinModelPortal P45563 http://www.proteinmodelportal.org/query/uniprot/P45563 PubMed 10400599 http://www.ncbi.nlm.nih.gov/pubmed/10400599 PubMed 15808857 http://www.ncbi.nlm.nih.gov/pubmed/15808857 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17151449 http://www.ncbi.nlm.nih.gov/pubmed/17151449 PubMed 3042752 http://www.ncbi.nlm.nih.gov/pubmed/3042752 PubMed 7007808 http://www.ncbi.nlm.nih.gov/pubmed/7007808 PubMed 7007809 http://www.ncbi.nlm.nih.gov/pubmed/7007809 PubMed 7559336 http://www.ncbi.nlm.nih.gov/pubmed/7559336 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416902 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416902 RefSeq WP_000084573 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000084573 SMR P45563 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45563 STRING 511145.b2407 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2407&targetmode=cogs STRING COG0005 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0005&targetmode=cogs SUPFAM SSF53167 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53167 TIGRFAMs TIGR01697 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01697 TIGRFAMs TIGR01699 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01699 UniProtKB XAPA_ECOLI http://www.uniprot.org/uniprot/XAPA_ECOLI UniProtKB-AC P45563 http://www.uniprot.org/uniprot/P45563 charge swissprot:XAPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:XAPA_ECOLI eggNOG COG0005 http://eggnogapi.embl.de/nog_data/html/tree/COG0005 eggNOG ENOG4107U5R http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107U5R epestfind swissprot:XAPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:XAPA_ECOLI garnier swissprot:XAPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:XAPA_ECOLI helixturnhelix swissprot:XAPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:XAPA_ECOLI hmoment swissprot:XAPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:XAPA_ECOLI iep swissprot:XAPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:XAPA_ECOLI inforesidue swissprot:XAPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:XAPA_ECOLI octanol swissprot:XAPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:XAPA_ECOLI pepcoil swissprot:XAPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:XAPA_ECOLI pepdigest swissprot:XAPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:XAPA_ECOLI pepinfo swissprot:XAPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:XAPA_ECOLI pepnet swissprot:XAPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:XAPA_ECOLI pepstats swissprot:XAPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:XAPA_ECOLI pepwheel swissprot:XAPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:XAPA_ECOLI pepwindow swissprot:XAPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:XAPA_ECOLI sigcleave swissprot:XAPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:XAPA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260147 10 # CDD cd01392 HTH_LacI # EcoGene EG13920 ycjW # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; ISS:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006974 cellular response to DNA damage stimulus; IMP:EcoCyc. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.260.40 -; 1. # IntAct P77615 4 # InterPro IPR000843 HTH_LacI # InterPro IPR001761 Peripla_BP/Lac1_sug-bd_dom # InterPro IPR010982 Lambda_DNA-bd_dom # InterPro IPR028082 Peripla_BP_I # Organism YCJW_ECOLI Escherichia coli (strain K12) # PATRIC 32117914 VBIEscCol129921_1377 # PIR C64881 C64881 # PRINTS PR00036 HTHLACI # PROSITE PS00356 HTH_LACI_1 # PROSITE PS50932 HTH_LACI_2 # Pfam PF00356 LacI # Pfam PF00532 Peripla_BP_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCJW_ECOLI Uncharacterized HTH-type transcriptional regulator YcjW # RefSeq NP_415836 NC_000913.3 # RefSeq WP_000075375 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lacI-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00111}. # SMART SM00354 HTH_LACI # SUPFAM SSF47413 SSF47413 # SUPFAM SSF53822 SSF53822 # eggNOG COG1609 LUCA # eggNOG ENOG4105FKQ Bacteria BLAST swissprot:YCJW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCJW_ECOLI BioCyc ECOL316407:JW1313-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1313-MONOMER BioCyc EcoCyc:G6658-MONOMER http://biocyc.org/getid?id=EcoCyc:G6658-MONOMER DIP DIP-11614N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11614N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3679 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3679 EcoGene EG13920 http://www.ecogene.org/geneInfo.php?eg_id=EG13920 EnsemblBacteria AAC74402 http://www.ensemblgenomes.org/id/AAC74402 EnsemblBacteria AAC74402 http://www.ensemblgenomes.org/id/AAC74402 EnsemblBacteria BAA14901 http://www.ensemblgenomes.org/id/BAA14901 EnsemblBacteria BAA14901 http://www.ensemblgenomes.org/id/BAA14901 EnsemblBacteria BAA14901 http://www.ensemblgenomes.org/id/BAA14901 EnsemblBacteria b1320 http://www.ensemblgenomes.org/id/b1320 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.260.40 http://www.cathdb.info/version/latest/superfamily/1.10.260.40 GeneID 945875 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945875 HOGENOM HOG000220180 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220180&db=HOGENOM6 InParanoid P77615 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77615 IntAct P77615 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77615* InterPro IPR000843 http://www.ebi.ac.uk/interpro/entry/IPR000843 InterPro IPR001761 http://www.ebi.ac.uk/interpro/entry/IPR001761 InterPro IPR010982 http://www.ebi.ac.uk/interpro/entry/IPR010982 InterPro IPR028082 http://www.ebi.ac.uk/interpro/entry/IPR028082 KEGG_Gene ecj:JW1313 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1313 KEGG_Gene eco:b1320 http://www.genome.jp/dbget-bin/www_bget?eco:b1320 OMA TAIFHAS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TAIFHAS PRINTS PR00036 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00036 PROSITE PS00356 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00356 PROSITE PS50932 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50932 PSORT swissprot:YCJW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCJW_ECOLI PSORT-B swissprot:YCJW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCJW_ECOLI PSORT2 swissprot:YCJW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCJW_ECOLI Pfam PF00356 http://pfam.xfam.org/family/PF00356 Pfam PF00532 http://pfam.xfam.org/family/PF00532 Phobius swissprot:YCJW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCJW_ECOLI PhylomeDB P77615 http://phylomedb.org/?seqid=P77615 ProteinModelPortal P77615 http://www.proteinmodelportal.org/query/uniprot/P77615 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415836 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415836 RefSeq WP_000075375 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000075375 SMART SM00354 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00354 STRING 511145.b1320 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1320&targetmode=cogs SUPFAM SSF47413 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47413 SUPFAM SSF53822 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822 UniProtKB YCJW_ECOLI http://www.uniprot.org/uniprot/YCJW_ECOLI UniProtKB-AC P77615 http://www.uniprot.org/uniprot/P77615 charge swissprot:YCJW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCJW_ECOLI eggNOG COG1609 http://eggnogapi.embl.de/nog_data/html/tree/COG1609 eggNOG ENOG4105FKQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FKQ epestfind swissprot:YCJW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCJW_ECOLI garnier swissprot:YCJW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCJW_ECOLI helixturnhelix swissprot:YCJW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCJW_ECOLI hmoment swissprot:YCJW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCJW_ECOLI iep swissprot:YCJW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCJW_ECOLI inforesidue swissprot:YCJW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCJW_ECOLI octanol swissprot:YCJW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCJW_ECOLI pepcoil swissprot:YCJW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCJW_ECOLI pepdigest swissprot:YCJW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCJW_ECOLI pepinfo swissprot:YCJW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCJW_ECOLI pepnet swissprot:YCJW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCJW_ECOLI pepstats swissprot:YCJW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCJW_ECOLI pepwheel swissprot:YCJW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCJW_ECOLI pepwindow swissprot:YCJW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCJW_ECOLI sigcleave swissprot:YCJW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCJW_ECOLI ## Database ID URL or Descriptions # BioGrid 4260257 113 # EcoGene EG13938 rsxE # FUNCTION RSXE_ECOLI Part of a membrane complex involved in electron transport. Required to maintain the reduced state of SoxR. {ECO 0000255|HAMAP-Rule MF_00478, ECO 0000269|PubMed 12773378}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0022900 electron transport chain; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006091 generation of precursor metabolites and energy # HAMAP MF_00478 RsxE_RnfE # InterPro IPR003667 Rnf-Nqr # InterPro IPR010968 RsxE # Organism RSXE_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30586:SF0 PTHR30586:SF0 # PATRIC 32118566 VBIEscCol129921_1703 # PIR B64920 B64920 # PIRSF PIRSF006102 NQR_DE # Pfam PF02508 Rnf-Nqr # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Electron transport complex subunit RsxE {ECO:0000255|HAMAP-Rule MF_00478} # RefSeq NP_416149 NC_000913.3 # RefSeq WP_001289652 NZ_LN832404.1 # SIMILARITY Belongs to the NqrDE/RnfAE family. {ECO:0000255|HAMAP- Rule MF_00478}. # SUBCELLULAR LOCATION RSXE_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_00478, ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255|HAMAP-Rule MF_00478, ECO 0000269|PubMed 15919996}. # SUBUNIT Composed of six subunits; RsxA, RsxB, RsxC, RsxD, RsxE and RsxG. {ECO:0000305|PubMed 12773378}. # TCDB 3.D.6.1:the putative ion (h(+) or na(+))-translocating nadh ferredoxin oxidoreductase (nfo or rnf) family # TIGRFAMs TIGR01948 rnfE # eggNOG COG4660 LUCA # eggNOG ENOG4105DZB Bacteria BLAST swissprot:RSXE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RSXE_ECOLI BioCyc ECOL316407:JW1624-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1624-MONOMER BioCyc EcoCyc:G6876-MONOMER http://biocyc.org/getid?id=EcoCyc:G6876-MONOMER COG COG1347 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1347 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.96.15.8540 http://dx.doi.org/10.1073/pnas.96.15.8540 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/emboj/cdg252 http://dx.doi.org/10.1093/emboj/cdg252 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3697 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3697 EcoGene EG13938 http://www.ecogene.org/geneInfo.php?eg_id=EG13938 EnsemblBacteria AAC74704 http://www.ensemblgenomes.org/id/AAC74704 EnsemblBacteria AAC74704 http://www.ensemblgenomes.org/id/AAC74704 EnsemblBacteria BAA15386 http://www.ensemblgenomes.org/id/BAA15386 EnsemblBacteria BAA15386 http://www.ensemblgenomes.org/id/BAA15386 EnsemblBacteria BAA15386 http://www.ensemblgenomes.org/id/BAA15386 EnsemblBacteria b1632 http://www.ensemblgenomes.org/id/b1632 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0022900 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022900 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GeneID 947509 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947509 HAMAP MF_00478 http://hamap.expasy.org/unirule/MF_00478 HOGENOM HOG000279325 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000279325&db=HOGENOM6 InParanoid P77179 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77179 InterPro IPR003667 http://www.ebi.ac.uk/interpro/entry/IPR003667 InterPro IPR010968 http://www.ebi.ac.uk/interpro/entry/IPR010968 KEGG_Gene ecj:JW1624 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1624 KEGG_Gene eco:b1632 http://www.genome.jp/dbget-bin/www_bget?eco:b1632 KEGG_Orthology KO:K03613 http://www.genome.jp/dbget-bin/www_bget?KO:K03613 OMA FDGFAMG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FDGFAMG PANTHER PTHR30586:SF0 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30586:SF0 PSORT swissprot:RSXE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RSXE_ECOLI PSORT-B swissprot:RSXE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RSXE_ECOLI PSORT2 swissprot:RSXE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RSXE_ECOLI Pfam PF02508 http://pfam.xfam.org/family/PF02508 Phobius swissprot:RSXE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RSXE_ECOLI PhylomeDB P77179 http://phylomedb.org/?seqid=P77179 ProteinModelPortal P77179 http://www.proteinmodelportal.org/query/uniprot/P77179 PubMed 10411911 http://www.ncbi.nlm.nih.gov/pubmed/10411911 PubMed 12773378 http://www.ncbi.nlm.nih.gov/pubmed/12773378 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416149 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416149 RefSeq WP_001289652 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001289652 STRING 511145.b1632 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1632&targetmode=cogs STRING COG1347 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1347&targetmode=cogs TCDB 3.D.6.1 http://www.tcdb.org/search/result.php?tc=3.D.6.1 TIGRFAMs TIGR01948 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01948 UniProtKB RSXE_ECOLI http://www.uniprot.org/uniprot/RSXE_ECOLI UniProtKB-AC P77179 http://www.uniprot.org/uniprot/P77179 charge swissprot:RSXE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RSXE_ECOLI eggNOG COG4660 http://eggnogapi.embl.de/nog_data/html/tree/COG4660 eggNOG ENOG4105DZB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DZB epestfind swissprot:RSXE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RSXE_ECOLI garnier swissprot:RSXE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RSXE_ECOLI helixturnhelix swissprot:RSXE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RSXE_ECOLI hmoment swissprot:RSXE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RSXE_ECOLI iep swissprot:RSXE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RSXE_ECOLI inforesidue swissprot:RSXE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RSXE_ECOLI octanol swissprot:RSXE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RSXE_ECOLI pepcoil swissprot:RSXE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RSXE_ECOLI pepdigest swissprot:RSXE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RSXE_ECOLI pepinfo swissprot:RSXE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RSXE_ECOLI pepnet swissprot:RSXE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RSXE_ECOLI pepstats swissprot:RSXE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RSXE_ECOLI pepwheel swissprot:RSXE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RSXE_ECOLI pepwindow swissprot:RSXE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RSXE_ECOLI sigcleave swissprot:RSXE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RSXE_ECOLI ## Database ID URL or Descriptions # AltName ARPA_ECOLI Ankyrin-like regulatory protein # BioGrid 4262004 4 # EcoGene EG11208 arpA # Gene3D 1.25.40.20 -; 1. # IntAct P23325 7 # InterPro IPR002110 Ankyrin_rpt # InterPro IPR012927 Toxin_15_N # InterPro IPR020683 Ankyrin_rpt-contain_dom # Organism ARPA_ECOLI Escherichia coli (strain K12) # PATRIC 32123563 VBIEscCol129921_4130 # PIR H65208 H65208 # Pfam PF07906 Toxin_15 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ARPA_ECOLI Ankyrin repeat protein A # RefSeq NP_418441 NC_000913.3 # RefSeq WP_000632913 NZ_LN832404.1 # SIMILARITY Contains 5 ANK repeats. {ECO 0000305}. # SMART SM00248 ANK; 6 # SUPFAM SSF48403 SSF48403 # eggNOG COG0666 LUCA BLAST swissprot:ARPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARPA_ECOLI BioCyc ECOL316407:JW3977-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3977-MONOMER BioCyc EcoCyc:EG11208-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11208-MONOMER COG COG0666 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0666 DIP DIP-9159N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9159N DOI 10.1006/jmbi.1994.1407 http://dx.doi.org/10.1006/jmbi.1994.1407 DOI 10.1016/0378-1119(91)90024-6 http://dx.doi.org/10.1016/0378-1119(91)90024-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M63497 http://www.ebi.ac.uk/ena/data/view/M63497 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1193 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1193 EcoGene EG11208 http://www.ecogene.org/geneInfo.php?eg_id=EG11208 EnsemblBacteria AAC76987 http://www.ensemblgenomes.org/id/AAC76987 EnsemblBacteria AAC76987 http://www.ensemblgenomes.org/id/AAC76987 EnsemblBacteria BAE78019 http://www.ensemblgenomes.org/id/BAE78019 EnsemblBacteria BAE78019 http://www.ensemblgenomes.org/id/BAE78019 EnsemblBacteria BAE78019 http://www.ensemblgenomes.org/id/BAE78019 EnsemblBacteria b4017 http://www.ensemblgenomes.org/id/b4017 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 1.25.40.20 http://www.cathdb.info/version/latest/superfamily/1.25.40.20 GeneID 944933 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944933 HOGENOM HOG000009667 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009667&db=HOGENOM6 InParanoid P23325 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23325 IntAct P23325 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P23325* InterPro IPR002110 http://www.ebi.ac.uk/interpro/entry/IPR002110 InterPro IPR012927 http://www.ebi.ac.uk/interpro/entry/IPR012927 InterPro IPR020683 http://www.ebi.ac.uk/interpro/entry/IPR020683 KEGG_Gene ecj:JW3977 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3977 KEGG_Gene eco:b4017 http://www.genome.jp/dbget-bin/www_bget?eco:b4017 KEGG_Orthology KO:K06867 http://www.genome.jp/dbget-bin/www_bget?KO:K06867 OMA FELGHRV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FELGHRV PSORT swissprot:ARPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARPA_ECOLI PSORT-B swissprot:ARPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARPA_ECOLI PSORT2 swissprot:ARPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARPA_ECOLI Pfam PF07906 http://pfam.xfam.org/family/PF07906 Phobius swissprot:ARPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARPA_ECOLI ProteinModelPortal P23325 http://www.proteinmodelportal.org/query/uniprot/P23325 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1995429 http://www.ncbi.nlm.nih.gov/pubmed/1995429 PubMed 8014990 http://www.ncbi.nlm.nih.gov/pubmed/8014990 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418441 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418441 RefSeq WP_000632913 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000632913 SMART SM00248 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00248 STRING 511145.b4017 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4017&targetmode=cogs STRING COG0666 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0666&targetmode=cogs SUPFAM SSF48403 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48403 UniProtKB ARPA_ECOLI http://www.uniprot.org/uniprot/ARPA_ECOLI UniProtKB-AC P23325 http://www.uniprot.org/uniprot/P23325 charge swissprot:ARPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARPA_ECOLI eggNOG COG0666 http://eggnogapi.embl.de/nog_data/html/tree/COG0666 epestfind swissprot:ARPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARPA_ECOLI garnier swissprot:ARPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARPA_ECOLI helixturnhelix swissprot:ARPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARPA_ECOLI hmoment swissprot:ARPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARPA_ECOLI iep swissprot:ARPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARPA_ECOLI inforesidue swissprot:ARPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARPA_ECOLI octanol swissprot:ARPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARPA_ECOLI pepcoil swissprot:ARPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARPA_ECOLI pepdigest swissprot:ARPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARPA_ECOLI pepinfo swissprot:ARPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARPA_ECOLI pepnet swissprot:ARPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARPA_ECOLI pepstats swissprot:ARPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARPA_ECOLI pepwheel swissprot:ARPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARPA_ECOLI pepwindow swissprot:ARPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARPA_ECOLI sigcleave swissprot:ARPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARPA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262499 510 # DISRUPTION PHENOTYPE FTSY_ECOLI Deletion affects both cell morphology and protein export. Mutants are defective in the insertion into the cytoplasmic membrane of three topologically distinct membrane proteins, MalF, AcrB and FtsQ. {ECO 0000269|PubMed 11741850, ECO 0000269|PubMed 8194520}. # DOMAIN FTSY_ECOLI Contains an acidic N-terminal A domain, a central N domain and a C-terminal GTPase G domain that can bind and hydrolyze GTP. Contains at least two lipid-binding sites. The first site contains the first 14 amino acids (helix 1) and the second binding site is an amphipathic alpha-helix located at the interface between the A- and the N-domain (helix 2). {ECO 0000255|HAMAP-Rule MF_00920, ECO 0000269|PubMed 17726012, ECO 0000269|PubMed 17726013, ECO 0000269|PubMed 18281057, ECO 0000269|PubMed 19414018, ECO 0000269|PubMed 9002525, ECO 0000269|PubMed 9177162, ECO 0000269|PubMed 9305630}. # ENZYME REGULATION Conformation of the Ffh-FtsY complex and regulation of its GTPase activity are modulated by the 4.5S RNA. Formation of the FfH-FtsY complex leads to a mutual stimulation of both GTPases. {ECO:0000269|PubMed 11735405}. # EcoGene EG10346 ftsY # FUNCTION FTSY_ECOLI Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. {ECO 0000255|HAMAP-Rule MF_00920, ECO 0000269|PubMed 11735405, ECO 0000269|PubMed 11741850, ECO 0000269|PubMed 15148364, ECO 0000269|PubMed 17682051, ECO 0000269|PubMed 8194520, ECO 0000269|PubMed 9305630}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0031226 intrinsic component of plasma membrane; IDA:EcoCyc. # GO_function GO:0003924 GTPase activity; IDA:EcoCyc. # GO_function GO:0005525 GTP binding; IDA:EcoCyc. # GO_process GO:0006614 SRP-dependent cotranslational protein targeting to membrane; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003924 GTPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006605 protein targeting # GOslim_process GO:0061024 membrane organization # Gene3D 3.40.50.300 -; 1. # HAMAP MF_00920 FtsY # IntAct P10121 6 # InterPro IPR000897 SRP54_GTPase_dom # InterPro IPR003593 AAA+_ATPase # InterPro IPR004390 SR_rcpt_FtsY # InterPro IPR013822 Signal_recog_particl_SRP54_hlx # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02044 M00335 Sec (secretion) system # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko03060 Protein export # KEGG_Pathway ko03070 Bacterial secretion system # Organism FTSY_ECOLI Escherichia coli (strain K12) # PATRIC 32122372 VBIEscCol129921_3563 # PDB 1FTS X-ray; 2.20 A; A=201-495 # PDB 2QY9 X-ray; 1.90 A; A=196-497 # PDB 2XXA X-ray; 3.94 A; B/D=196-497 # PDB 2YHS X-ray; 1.60 A; A=1-497 # PDB 3ZN8 EM; 12.00 A; D=201-495 # PDB 4C7O X-ray; 2.60 A; B/D=224-497 # PDB 5GAD EM; 3.70 A; l=1-497 # PIR S03130 CEECFY # PROSITE PS00300 SRP54 # PTM FTSY_ECOLI Proteolytically cleaved. The cleavage may regulate function and subcellular location of FtsY. Full-length FtsY is found primarily associated with the membrane, while cleaved protein is predominantly present in the cytoplasm. {ECO 0000269|PubMed 18281057}. # Pfam PF00448 SRP54 # Pfam PF02881 SRP54_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Signal recognition particle receptor FtsY {ECO:0000255|HAMAP-Rule MF_00920} # RefSeq NP_417921 NC_000913.3 # RefSeq WP_001040654 NZ_LN832404.1 # SIMILARITY Belongs to the GTP-binding SRP family. FtsY subfamily. {ECO:0000255|HAMAP-Rule MF_00920}. # SMART SM00382 AAA # SMART SM00962 SRP54 # SMART SM00963 SRP54_N # SUBCELLULAR LOCATION FTSY_ECOLI Cell inner membrane {ECO 0000269|PubMed 11353766, ECO 0000269|PubMed 17726013, ECO 0000269|PubMed 18281057, ECO 0000269|PubMed 19414018, ECO 0000269|PubMed 21543314, ECO 0000269|PubMed 8194520, ECO 0000269|PubMed 9177162}; Peripheral membrane protein {ECO 0000269|PubMed 11353766, ECO 0000269|PubMed 17726013, ECO 0000269|PubMed 18281057, ECO 0000269|PubMed 19414018, ECO 0000269|PubMed 21543314, ECO 0000269|PubMed 8194520, ECO 0000269|PubMed 9177162}; Cytoplasmic side {ECO 0000269|PubMed 11353766, ECO 0000269|PubMed 17726013, ECO 0000269|PubMed 18281057, ECO 0000269|PubMed 19414018, ECO 0000269|PubMed 21543314, ECO 0000269|PubMed 8194520, ECO 0000269|PubMed 9177162}. Cytoplasm {ECO 0000269|PubMed 18281057, ECO 0000269|PubMed 8194520}. Note=Distributed between the membrane and the cytoplasm (PubMed 18281057, PubMed 8194520). Binding to the membrane probably occurs initially through phospholipid binding, which allows a strong membrane contact, followed by interaction with a membrane protein (PubMed 11353766). Targeting of FtsY to the membrane is essential for proper function (PubMed 9177162). The stability of this membrane contact may be regulated by cleavage of helix 1 (PubMed 19414018). {ECO 0000269|PubMed 11353766, ECO 0000269|PubMed 18281057, ECO 0000269|PubMed 19414018, ECO 0000269|PubMed 8194520, ECO 0000269|PubMed 9177162}. # SUBUNIT FTSY_ECOLI Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule. Binds to SecY. {ECO 0000255|HAMAP-Rule MF_00920, ECO 0000269|PubMed 21330537, ECO 0000269|PubMed 9305630}. # SUPFAM SSF47364 SSF47364 # SUPFAM SSF52540 SSF52540 # TCDB 3.A.5.1 the general secretory pathway (sec) family # TIGRFAMs TIGR00064 ftsY # eggNOG COG0552 LUCA # eggNOG ENOG4105CCP Bacteria BLAST swissprot:FTSY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FTSY_ECOLI BioCyc ECOL316407:JW3429-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3429-MONOMER BioCyc EcoCyc:EG10346-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10346-MONOMER COG COG0552 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0552 DIP DIP-9709N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9709N DOI 10.1007/BF02428043 http://dx.doi.org/10.1007/BF02428043 DOI 10.1016/j.bbamem.2010.07.025 http://dx.doi.org/10.1016/j.bbamem.2010.07.025 DOI 10.1016/j.jmb.2008.01.040 http://dx.doi.org/10.1016/j.jmb.2008.01.040 DOI 10.1016/j.jmb.2009.04.061 http://dx.doi.org/10.1016/j.jmb.2009.04.061 DOI 10.1021/bi011639y http://dx.doi.org/10.1021/bi011639y DOI 10.1038/385365a0 http://dx.doi.org/10.1038/385365a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0402231101 http://dx.doi.org/10.1073/pnas.0402231101 DOI 10.1073/pnas.94.12.6025 http://dx.doi.org/10.1073/pnas.94.12.6025 DOI 10.1074/jbc.M011331200 http://dx.doi.org/10.1074/jbc.M011331200 DOI 10.1074/jbc.M110.212340 http://dx.doi.org/10.1074/jbc.M110.212340 DOI 10.1074/jbc.M705429200 http://dx.doi.org/10.1074/jbc.M705429200 DOI 10.1074/jbc.M705430200 http://dx.doi.org/10.1074/jbc.M705430200 DOI 10.1083/jcb.200702018 http://dx.doi.org/10.1083/jcb.200702018 DOI 10.1093/emboj/16.16.4880 http://dx.doi.org/10.1093/emboj/16.16.4880 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1111/j.1365-2958.1990.tb00626.x http://dx.doi.org/10.1111/j.1365-2958.1990.tb00626.x DOI 10.1111/j.1600-0854.2011.01167.x http://dx.doi.org/10.1111/j.1600-0854.2011.01167.x DOI 10.1126/science.1196473 http://dx.doi.org/10.1126/science.1196473 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.1.111-118.2002 http://dx.doi.org/10.1128/JB.184.1.111-118.2002 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X04398 http://www.ebi.ac.uk/ena/data/view/X04398 EchoBASE EB0342 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0342 EcoGene EG10346 http://www.ecogene.org/geneInfo.php?eg_id=EG10346 EnsemblBacteria AAC76489 http://www.ensemblgenomes.org/id/AAC76489 EnsemblBacteria AAC76489 http://www.ensemblgenomes.org/id/AAC76489 EnsemblBacteria BAE77829 http://www.ensemblgenomes.org/id/BAE77829 EnsemblBacteria BAE77829 http://www.ensemblgenomes.org/id/BAE77829 EnsemblBacteria BAE77829 http://www.ensemblgenomes.org/id/BAE77829 EnsemblBacteria b3464 http://www.ensemblgenomes.org/id/b3464 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0031226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031226 GO_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_process GO:0006614 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006614 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006605 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006605 GOslim_process GO:0061024 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947978 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947978 HAMAP MF_00920 http://hamap.expasy.org/unirule/MF_00920 HOGENOM HOG000036278 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000036278&db=HOGENOM6 InParanoid P10121 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P10121 IntAct P10121 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P10121* InterPro IPR000897 http://www.ebi.ac.uk/interpro/entry/IPR000897 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR004390 http://www.ebi.ac.uk/interpro/entry/IPR004390 InterPro IPR013822 http://www.ebi.ac.uk/interpro/entry/IPR013822 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW3429 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3429 KEGG_Gene eco:b3464 http://www.genome.jp/dbget-bin/www_bget?eco:b3464 KEGG_Orthology KO:K03110 http://www.genome.jp/dbget-bin/www_bget?KO:K03110 KEGG_Pathway ko03060 http://www.genome.jp/kegg-bin/show_pathway?ko03060 KEGG_Pathway ko03070 http://www.genome.jp/kegg-bin/show_pathway?ko03070 MINT MINT-1247716 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1247716 OMA EGQKQET http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EGQKQET PDB 1FTS http://www.ebi.ac.uk/pdbe-srv/view/entry/1FTS PDB 2QY9 http://www.ebi.ac.uk/pdbe-srv/view/entry/2QY9 PDB 2XXA http://www.ebi.ac.uk/pdbe-srv/view/entry/2XXA PDB 2YHS http://www.ebi.ac.uk/pdbe-srv/view/entry/2YHS PDB 3ZN8 http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZN8 PDB 4C7O http://www.ebi.ac.uk/pdbe-srv/view/entry/4C7O PDB 5GAD http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAD PDBsum 1FTS http://www.ebi.ac.uk/pdbsum/1FTS PDBsum 2QY9 http://www.ebi.ac.uk/pdbsum/2QY9 PDBsum 2XXA http://www.ebi.ac.uk/pdbsum/2XXA PDBsum 2YHS http://www.ebi.ac.uk/pdbsum/2YHS PDBsum 3ZN8 http://www.ebi.ac.uk/pdbsum/3ZN8 PDBsum 4C7O http://www.ebi.ac.uk/pdbsum/4C7O PDBsum 5GAD http://www.ebi.ac.uk/pdbsum/5GAD PROSITE PS00300 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00300 PSORT swissprot:FTSY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FTSY_ECOLI PSORT-B swissprot:FTSY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FTSY_ECOLI PSORT2 swissprot:FTSY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FTSY_ECOLI Pfam PF00448 http://pfam.xfam.org/family/PF00448 Pfam PF02881 http://pfam.xfam.org/family/PF02881 Phobius swissprot:FTSY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FTSY_ECOLI PhylomeDB P10121 http://phylomedb.org/?seqid=P10121 ProteinModelPortal P10121 http://www.proteinmodelportal.org/query/uniprot/P10121 PubMed 11353766 http://www.ncbi.nlm.nih.gov/pubmed/11353766 PubMed 11735405 http://www.ncbi.nlm.nih.gov/pubmed/11735405 PubMed 11741850 http://www.ncbi.nlm.nih.gov/pubmed/11741850 PubMed 15148364 http://www.ncbi.nlm.nih.gov/pubmed/15148364 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17682051 http://www.ncbi.nlm.nih.gov/pubmed/17682051 PubMed 17726012 http://www.ncbi.nlm.nih.gov/pubmed/17726012 PubMed 17726013 http://www.ncbi.nlm.nih.gov/pubmed/17726013 PubMed 18281057 http://www.ncbi.nlm.nih.gov/pubmed/18281057 PubMed 19414018 http://www.ncbi.nlm.nih.gov/pubmed/19414018 PubMed 20682283 http://www.ncbi.nlm.nih.gov/pubmed/20682283 PubMed 21255212 http://www.ncbi.nlm.nih.gov/pubmed/21255212 PubMed 21330537 http://www.ncbi.nlm.nih.gov/pubmed/21330537 PubMed 21543314 http://www.ncbi.nlm.nih.gov/pubmed/21543314 PubMed 2161989 http://www.ncbi.nlm.nih.gov/pubmed/2161989 PubMed 3025556 http://www.ncbi.nlm.nih.gov/pubmed/3025556 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 8194520 http://www.ncbi.nlm.nih.gov/pubmed/8194520 PubMed 9002525 http://www.ncbi.nlm.nih.gov/pubmed/9002525 PubMed 9177162 http://www.ncbi.nlm.nih.gov/pubmed/9177162 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9305630 http://www.ncbi.nlm.nih.gov/pubmed/9305630 RefSeq NP_417921 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417921 RefSeq WP_001040654 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001040654 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMART SM00962 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00962 SMART SM00963 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00963 SMR P10121 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P10121 STRING 511145.b3464 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3464&targetmode=cogs STRING COG0552 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0552&targetmode=cogs SUPFAM SSF47364 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47364 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.5.1 http://www.tcdb.org/search/result.php?tc=3.A.5.1 TIGRFAMs TIGR00064 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00064 UniProtKB FTSY_ECOLI http://www.uniprot.org/uniprot/FTSY_ECOLI UniProtKB-AC P10121 http://www.uniprot.org/uniprot/P10121 charge swissprot:FTSY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FTSY_ECOLI eggNOG COG0552 http://eggnogapi.embl.de/nog_data/html/tree/COG0552 eggNOG ENOG4105CCP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CCP epestfind swissprot:FTSY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FTSY_ECOLI garnier swissprot:FTSY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FTSY_ECOLI helixturnhelix swissprot:FTSY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FTSY_ECOLI hmoment swissprot:FTSY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FTSY_ECOLI iep swissprot:FTSY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FTSY_ECOLI inforesidue swissprot:FTSY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FTSY_ECOLI octanol swissprot:FTSY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FTSY_ECOLI pepcoil swissprot:FTSY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FTSY_ECOLI pepdigest swissprot:FTSY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FTSY_ECOLI pepinfo swissprot:FTSY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FTSY_ECOLI pepnet swissprot:FTSY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FTSY_ECOLI pepstats swissprot:FTSY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FTSY_ECOLI pepwheel swissprot:FTSY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FTSY_ECOLI pepwindow swissprot:FTSY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FTSY_ECOLI sigcleave swissprot:FTSY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FTSY_ECOLI ## Database ID URL or Descriptions # BioGrid 4260115 13 # EcoGene EG11251 sirB1 # Gene3D 1.25.40.10 -; 1. # IntAct P0AGM5 5 # InterPro IPR011990 TPR-like_helical_dom # InterPro IPR032698 SirB1_N # Organism SIRB1_ECOLI Escherichia coli (strain K12) # PATRIC 32117680 VBIEscCol129921_1262 # PIR I83572 I83572 # Pfam PF13369 Transglut_core2 # Pfam PF13371 TPR_9 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SIRB1_ECOLI Protein sirB1 # RefSeq NP_415732 NC_000913.3 # RefSeq WP_001257044 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA05916.1; Type=Frameshift; Positions=97; Evidence={ECO 0000305}; # SIMILARITY Belongs to the UPF0162 family. {ECO 0000305}. # eggNOG COG2912 LUCA # eggNOG ENOG41063JG Bacteria BLAST swissprot:SIRB1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SIRB1_ECOLI BioCyc ECOL316407:JW1205-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1205-MONOMER BioCyc EcoCyc:EG11251-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11251-MONOMER DIP DIP-35939N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35939N DOI 10.1007/BF00331603 http://dx.doi.org/10.1007/BF00331603 DOI 10.1016/0378-1119(94)00805-3 http://dx.doi.org/10.1016/0378-1119(94)00805-3 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D28567 http://www.ebi.ac.uk/ena/data/view/D28567 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18555 http://www.ebi.ac.uk/ena/data/view/U18555 EMBL X05552 http://www.ebi.ac.uk/ena/data/view/X05552 EchoBASE EB1231 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1231 EcoGene EG11251 http://www.ecogene.org/geneInfo.php?eg_id=EG11251 EnsemblBacteria AAC74298 http://www.ensemblgenomes.org/id/AAC74298 EnsemblBacteria AAC74298 http://www.ensemblgenomes.org/id/AAC74298 EnsemblBacteria BAA36072 http://www.ensemblgenomes.org/id/BAA36072 EnsemblBacteria BAA36072 http://www.ensemblgenomes.org/id/BAA36072 EnsemblBacteria BAA36072 http://www.ensemblgenomes.org/id/BAA36072 EnsemblBacteria b1214 http://www.ensemblgenomes.org/id/b1214 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 1.25.40.10 http://www.cathdb.info/version/latest/superfamily/1.25.40.10 GeneID 945784 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945784 HOGENOM HOG000281267 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000281267&db=HOGENOM6 InParanoid P0AGM5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGM5 IntAct P0AGM5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AGM5* InterPro IPR011990 http://www.ebi.ac.uk/interpro/entry/IPR011990 InterPro IPR032698 http://www.ebi.ac.uk/interpro/entry/IPR032698 KEGG_Gene ecj:JW1205 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1205 KEGG_Gene eco:b1214 http://www.genome.jp/dbget-bin/www_bget?eco:b1214 OMA DGEMWLI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DGEMWLI PSORT swissprot:SIRB1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SIRB1_ECOLI PSORT-B swissprot:SIRB1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SIRB1_ECOLI PSORT2 swissprot:SIRB1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SIRB1_ECOLI Pfam PF13369 http://pfam.xfam.org/family/PF13369 Pfam PF13371 http://pfam.xfam.org/family/PF13371 Phobius swissprot:SIRB1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SIRB1_ECOLI PhylomeDB P0AGM5 http://phylomedb.org/?seqid=P0AGM5 ProteinModelPortal P0AGM5 http://www.proteinmodelportal.org/query/uniprot/P0AGM5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3039295 http://www.ncbi.nlm.nih.gov/pubmed/3039295 PubMed 7543480 http://www.ncbi.nlm.nih.gov/pubmed/7543480 PubMed 7883187 http://www.ncbi.nlm.nih.gov/pubmed/7883187 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415732 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415732 RefSeq WP_001257044 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001257044 SMR P0AGM5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AGM5 STRING 511145.b1214 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1214&targetmode=cogs UniProtKB SIRB1_ECOLI http://www.uniprot.org/uniprot/SIRB1_ECOLI UniProtKB-AC P0AGM5 http://www.uniprot.org/uniprot/P0AGM5 charge swissprot:SIRB1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SIRB1_ECOLI eggNOG COG2912 http://eggnogapi.embl.de/nog_data/html/tree/COG2912 eggNOG ENOG41063JG http://eggnogapi.embl.de/nog_data/html/tree/ENOG41063JG epestfind swissprot:SIRB1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SIRB1_ECOLI garnier swissprot:SIRB1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SIRB1_ECOLI helixturnhelix swissprot:SIRB1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SIRB1_ECOLI hmoment swissprot:SIRB1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SIRB1_ECOLI iep swissprot:SIRB1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SIRB1_ECOLI inforesidue swissprot:SIRB1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SIRB1_ECOLI octanol swissprot:SIRB1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SIRB1_ECOLI pepcoil swissprot:SIRB1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SIRB1_ECOLI pepdigest swissprot:SIRB1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SIRB1_ECOLI pepinfo swissprot:SIRB1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SIRB1_ECOLI pepnet swissprot:SIRB1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SIRB1_ECOLI pepstats swissprot:SIRB1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SIRB1_ECOLI pepwheel swissprot:SIRB1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SIRB1_ECOLI pepwindow swissprot:SIRB1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SIRB1_ECOLI sigcleave swissprot:SIRB1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SIRB1_ECOLI ## Database ID URL or Descriptions # CAUTION Could be the product of a pseudogene. The function of BcsQ was determined in a cellulose-producing E.coli strain 1094, which has an intact copy of the gene. {ECO 0000305}. # DISRUPTION PHENOTYPE Deletion abolishes cellulose production. {ECO:0000269|PubMed 19400787}. # DOMAIN BCSQ_ECOLI The N-terminal putative ATP-binding domain is required for function. The C-terminal region contributes to both localization and function in cellulose synthesis. {ECO 0000269|PubMed 19400787}. # EcoGene EG12261 bcsQ # FUNCTION BCSQ_ECOLI Essential for cellulose biosynthesis. May play a role in subcellular localization of an active cellulose biosynthesis apparatus at the bacterial cell pole. {ECO 0000269|PubMed 19400787}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0090540 bacterial cellulose biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.300 -; 1. # IntAct P37655 2 # InterPro IPR017746 Cellulose_synthase_operon_BcsQ # InterPro IPR027417 P-loop_NTPase # MISCELLANEOUS BCSQ_ECOLI Cellulose production is abolished in E.coli K12. # Organism BCSQ_ECOLI Escherichia coli (strain K12) # PIR S47756 S47756 # Pfam PF06564 CBP_BcsQ # Proteomes UP000000625 Chromosome # RecName BCSQ_ECOLI Putative cellulose biosynthesis protein BcsQ # SEQUENCE CAUTION Sequence=AAB18512.1; Type=Erroneous termination; Positions=6; Note=Translated as Leu.; Evidence={ECO:0000305}; Sequence=U00096; Type=Erroneous termination; Positions=6; Note=Translated as Leu.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the BcsQ family. {ECO 0000305}. # SUBCELLULAR LOCATION BCSQ_ECOLI Cytoplasm {ECO 0000269|PubMed 19400787}. Note=Localizes at the cell pole. # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR03371 cellulose_yhjQ BLAST swissprot:BCSQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BCSQ_ECOLI BioCyc EcoCyc:EG12261-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12261-MONOMER DIP DIP-12388N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12388N DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1111/j.1365-2958.2009.06678.x http://dx.doi.org/10.1111/j.1365-2958.2009.06678.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2170 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2170 EcoGene EG12261 http://www.ecogene.org/geneInfo.php?eg_id=EG12261 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0090540 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090540 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 HOGENOM HOG000125946 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125946&db=HOGENOM6 InParanoid P37655 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37655 IntAct P37655 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37655* InterPro IPR017746 http://www.ebi.ac.uk/interpro/entry/IPR017746 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 MINT MINT-1223715 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1223715 OMA VVHRDEA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VVHRDEA PSORT swissprot:BCSQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BCSQ_ECOLI PSORT-B swissprot:BCSQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BCSQ_ECOLI PSORT2 swissprot:BCSQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BCSQ_ECOLI Pfam PF06564 http://pfam.xfam.org/family/PF06564 Phobius swissprot:BCSQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BCSQ_ECOLI ProteinModelPortal P37655 http://www.proteinmodelportal.org/query/uniprot/P37655 PubMed 19400787 http://www.ncbi.nlm.nih.gov/pubmed/19400787 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR03371 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03371 UniProtKB BCSQ_ECOLI http://www.uniprot.org/uniprot/BCSQ_ECOLI UniProtKB-AC P37655 http://www.uniprot.org/uniprot/P37655 charge swissprot:BCSQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BCSQ_ECOLI epestfind swissprot:BCSQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BCSQ_ECOLI garnier swissprot:BCSQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BCSQ_ECOLI helixturnhelix swissprot:BCSQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BCSQ_ECOLI hmoment swissprot:BCSQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BCSQ_ECOLI iep swissprot:BCSQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BCSQ_ECOLI inforesidue swissprot:BCSQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BCSQ_ECOLI octanol swissprot:BCSQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BCSQ_ECOLI pepcoil swissprot:BCSQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BCSQ_ECOLI pepdigest swissprot:BCSQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BCSQ_ECOLI pepinfo swissprot:BCSQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BCSQ_ECOLI pepnet swissprot:BCSQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BCSQ_ECOLI pepstats swissprot:BCSQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BCSQ_ECOLI pepwheel swissprot:BCSQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BCSQ_ECOLI pepwindow swissprot:BCSQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BCSQ_ECOLI sigcleave swissprot:BCSQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BCSQ_ECOLI ## Database ID URL or Descriptions # BRENDA 2.7.13 2026 # BioGrid 4262011 13 # CATALYTIC ACTIVITY ATOS_ECOLI ATP + protein L-histidine = ADP + protein N- phospho-L-histidine. # EcoGene EG11667 atoS # FUNCTION ATOS_ECOLI Member of the two-component regulatory system AtoS/AtoC; may activate AtoC by phosphorylation. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0000155 phosphorelay sensor kinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IMP:EcoCyc. # GO_process GO:0000160 phosphorelay signal transduction system; IDA:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:InterPro. # GO_process GO:0046777 protein autophosphorylation; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005622 intracellular # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # Gene3D 1.10.287.130 -; 1. # Gene3D 3.30.565.10 -; 1. # IntAct Q06067 2 # InterPro IPR000014 PAS # InterPro IPR000700 PAS-assoc_C # InterPro IPR003594 HATPase_C # InterPro IPR003660 HAMP_dom # InterPro IPR003661 HisK_dim/P # InterPro IPR004358 Sig_transdc_His_kin-like_C # InterPro IPR005467 His_kinase_dom # InterPro IPR013767 PAS_fold # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01001 Protein kinases # KEGG_Brite ko02022 M00500 AtoS-AtoC (complexed poly-(R)-3-hydroxybutyrate biosynthesis) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # Organism ATOS_ECOLI Escherichia coli (strain K12) # PATRIC 32119797 VBIEscCol129921_2308 # PIR A64992 A64992 # PRINTS PR00344 BCTRLSENSOR # PROSITE PS50109 HIS_KIN # PROSITE PS50112 PAS # PROSITE PS50113 PAC # PROSITE PS50885 HAMP # Pfam PF00512 HisKA # Pfam PF00672 HAMP # Pfam PF00989 PAS # Pfam PF02518 HATPase_c # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ATOS_ECOLI Signal transduction histidine-protein kinase AtoS # RefSeq NP_416723 NC_000913.3 # RefSeq WP_000559125 NZ_LN832404.1 # SIMILARITY Contains 1 HAMP domain. {ECO:0000255|PROSITE- ProRule PRU00102}. # SIMILARITY Contains 1 PAC (PAS-associated C-terminal) domain. {ECO:0000255|PROSITE-ProRule PRU00141}. # SIMILARITY Contains 1 PAS (PER-ARNT-SIM) domain. {ECO:0000255|PROSITE-ProRule PRU00140}. # SIMILARITY Contains 1 histidine kinase domain. {ECO:0000255|PROSITE-ProRule PRU00107}. # SMART SM00091 PAS # SMART SM00304 HAMP # SMART SM00387 HATPase_c # SMART SM00388 HisKA # SUBCELLULAR LOCATION ATOS_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # SUPFAM SSF47384 SSF47384 # SUPFAM SSF55785 SSF55785 # SUPFAM SSF55874 SSF55874 # TIGRFAMs TIGR00229 sensory_box # eggNOG COG0642 LUCA # eggNOG COG2202 LUCA # eggNOG ENOG4105BZU Bacteria BLAST swissprot:ATOS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ATOS_ECOLI BioCyc ECOL316407:JW2213-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2213-MONOMER BioCyc EcoCyc:ATOS-MONOMER http://biocyc.org/getid?id=EcoCyc:ATOS-MONOMER COG COG0642 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0642 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.90.15.7129 http://dx.doi.org/10.1073/pnas.90.15.7129 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.13.3 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.13.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L13078 http://www.ebi.ac.uk/ena/data/view/L13078 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.13.3 http://enzyme.expasy.org/EC/2.7.13.3 EchoBASE EB1618 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1618 EcoGene EG11667 http://www.ecogene.org/geneInfo.php?eg_id=EG11667 EnsemblBacteria AAC75279 http://www.ensemblgenomes.org/id/AAC75279 EnsemblBacteria AAC75279 http://www.ensemblgenomes.org/id/AAC75279 EnsemblBacteria BAA16015 http://www.ensemblgenomes.org/id/BAA16015 EnsemblBacteria BAA16015 http://www.ensemblgenomes.org/id/BAA16015 EnsemblBacteria BAA16015 http://www.ensemblgenomes.org/id/BAA16015 EnsemblBacteria b2219 http://www.ensemblgenomes.org/id/b2219 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0000155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000155 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0046777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046777 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.10.287.130 http://www.cathdb.info/version/latest/superfamily/1.10.287.130 Gene3D 3.30.565.10 http://www.cathdb.info/version/latest/superfamily/3.30.565.10 GeneID 949011 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949011 HOGENOM HOG000122301 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122301&db=HOGENOM6 InParanoid Q06067 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q06067 IntAct Q06067 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q06067* IntEnz 2.7.13.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.13.3 InterPro IPR000014 http://www.ebi.ac.uk/interpro/entry/IPR000014 InterPro IPR000700 http://www.ebi.ac.uk/interpro/entry/IPR000700 InterPro IPR003594 http://www.ebi.ac.uk/interpro/entry/IPR003594 InterPro IPR003660 http://www.ebi.ac.uk/interpro/entry/IPR003660 InterPro IPR003661 http://www.ebi.ac.uk/interpro/entry/IPR003661 InterPro IPR004358 http://www.ebi.ac.uk/interpro/entry/IPR004358 InterPro IPR005467 http://www.ebi.ac.uk/interpro/entry/IPR005467 InterPro IPR013767 http://www.ebi.ac.uk/interpro/entry/IPR013767 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01001 http://www.genome.jp/dbget-bin/www_bget?ko01001 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW2213 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2213 KEGG_Gene eco:b2219 http://www.genome.jp/dbget-bin/www_bget?eco:b2219 KEGG_Orthology KO:K07710 http://www.genome.jp/dbget-bin/www_bget?KO:K07710 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA EIAITCA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EIAITCA PRINTS PR00344 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00344 PROSITE PS50109 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50109 PROSITE PS50112 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50112 PROSITE PS50113 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50113 PROSITE PS50885 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50885 PSORT swissprot:ATOS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ATOS_ECOLI PSORT-B swissprot:ATOS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ATOS_ECOLI PSORT2 swissprot:ATOS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ATOS_ECOLI Pfam PF00512 http://pfam.xfam.org/family/PF00512 Pfam PF00672 http://pfam.xfam.org/family/PF00672 Pfam PF00989 http://pfam.xfam.org/family/PF00989 Pfam PF02518 http://pfam.xfam.org/family/PF02518 Phobius swissprot:ATOS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ATOS_ECOLI PhylomeDB Q06067 http://phylomedb.org/?seqid=Q06067 ProteinModelPortal Q06067 http://www.proteinmodelportal.org/query/uniprot/Q06067 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8346225 http://www.ncbi.nlm.nih.gov/pubmed/8346225 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416723 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416723 RefSeq WP_000559125 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000559125 SMART SM00091 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00091 SMART SM00304 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00304 SMART SM00387 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00387 SMART SM00388 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00388 SMR Q06067 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q06067 STRING 511145.b2219 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2219&targetmode=cogs STRING COG0642 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0642&targetmode=cogs SUPFAM SSF47384 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47384 SUPFAM SSF55785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55785 SUPFAM SSF55874 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55874 TIGRFAMs TIGR00229 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00229 UniProtKB ATOS_ECOLI http://www.uniprot.org/uniprot/ATOS_ECOLI UniProtKB-AC Q06067 http://www.uniprot.org/uniprot/Q06067 charge swissprot:ATOS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ATOS_ECOLI eggNOG COG0642 http://eggnogapi.embl.de/nog_data/html/tree/COG0642 eggNOG COG2202 http://eggnogapi.embl.de/nog_data/html/tree/COG2202 eggNOG ENOG4105BZU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZU epestfind swissprot:ATOS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ATOS_ECOLI garnier swissprot:ATOS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ATOS_ECOLI helixturnhelix swissprot:ATOS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ATOS_ECOLI hmoment swissprot:ATOS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ATOS_ECOLI iep swissprot:ATOS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ATOS_ECOLI inforesidue swissprot:ATOS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ATOS_ECOLI octanol swissprot:ATOS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ATOS_ECOLI pepcoil swissprot:ATOS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ATOS_ECOLI pepdigest swissprot:ATOS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ATOS_ECOLI pepinfo swissprot:ATOS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ATOS_ECOLI pepnet swissprot:ATOS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ATOS_ECOLI pepstats swissprot:ATOS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ATOS_ECOLI pepwheel swissprot:ATOS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ATOS_ECOLI pepwindow swissprot:ATOS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ATOS_ECOLI sigcleave swissprot:ATOS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ATOS_ECOLI ## Database ID URL or Descriptions # BioGrid 4260859 2 # EcoGene EG12971 ygfF # GO_function GO:0016491 oxidoreductase activity; IEA:UniProtKB-KW. # GOslim_function GO:0016491 oxidoreductase activity # Gene3D 3.40.50.720 -; 1. # IntAct P52037 3 # InterPro IPR002347 SDR_fam # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR020904 Sc_DH/Rdtase_CS # Organism YGFF_ECOLI Escherichia coli (strain K12) # PANTHER PTHR24322 PTHR24322; 2 # PATRIC 32121218 VBIEscCol129921_2997 # PIR F65074 F65074 # PRINTS PR00080 SDRFAMILY # PRINTS PR00081 GDHRDH # PROSITE PS00061 ADH_SHORT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGFF_ECOLI Uncharacterized oxidoreductase YgfF # RefSeq NP_417378 NC_000913.3 # RefSeq WP_000951964 NZ_LN832404.1 # SIMILARITY Belongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO 0000305}. # SUPFAM SSF51735 SSF51735 # eggNOG ENOG4105CYX Bacteria # eggNOG ENOG410XNUN LUCA BLAST swissprot:YGFF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGFF_ECOLI BioCyc ECOL316407:JW2870-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2870-MONOMER BioCyc EcoCyc:G7514-MONOMER http://biocyc.org/getid?id=EcoCyc:G7514-MONOMER DIP DIP-12165N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12165N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1271/bbb.58.117 http://dx.doi.org/10.1271/bbb.58.117 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D21144 http://www.ebi.ac.uk/ena/data/view/D21144 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EMBL U83189 http://www.ebi.ac.uk/ena/data/view/U83189 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- EchoBASE EB2798 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2798 EcoGene EG12971 http://www.ecogene.org/geneInfo.php?eg_id=EG12971 EnsemblBacteria AAC75940 http://www.ensemblgenomes.org/id/AAC75940 EnsemblBacteria AAC75940 http://www.ensemblgenomes.org/id/AAC75940 EnsemblBacteria BAE76967 http://www.ensemblgenomes.org/id/BAE76967 EnsemblBacteria BAE76967 http://www.ensemblgenomes.org/id/BAE76967 EnsemblBacteria BAE76967 http://www.ensemblgenomes.org/id/BAE76967 EnsemblBacteria b2902 http://www.ensemblgenomes.org/id/b2902 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 947373 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947373 InParanoid P52037 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P52037 IntAct P52037 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P52037* IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR002347 http://www.ebi.ac.uk/interpro/entry/IPR002347 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR020904 http://www.ebi.ac.uk/interpro/entry/IPR020904 KEGG_Gene ecj:JW2870 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2870 KEGG_Gene eco:b2902 http://www.genome.jp/dbget-bin/www_bget?eco:b2902 MINT MINT-1242731 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1242731 OMA IARVACF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IARVACF PANTHER PTHR24322 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24322 PRINTS PR00080 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00080 PRINTS PR00081 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00081 PROSITE PS00061 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00061 PSORT swissprot:YGFF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGFF_ECOLI PSORT-B swissprot:YGFF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGFF_ECOLI PSORT2 swissprot:YGFF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGFF_ECOLI Phobius swissprot:YGFF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGFF_ECOLI PhylomeDB P52037 http://phylomedb.org/?seqid=P52037 ProteinModelPortal P52037 http://www.proteinmodelportal.org/query/uniprot/P52037 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7764507 http://www.ncbi.nlm.nih.gov/pubmed/7764507 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417378 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417378 RefSeq WP_000951964 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000951964 SMR P52037 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P52037 STRING 511145.b2902 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2902&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB YGFF_ECOLI http://www.uniprot.org/uniprot/YGFF_ECOLI UniProtKB-AC P52037 http://www.uniprot.org/uniprot/P52037 charge swissprot:YGFF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGFF_ECOLI eggNOG ENOG4105CYX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CYX eggNOG ENOG410XNUN http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNUN epestfind swissprot:YGFF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGFF_ECOLI garnier swissprot:YGFF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGFF_ECOLI helixturnhelix swissprot:YGFF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGFF_ECOLI hmoment swissprot:YGFF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGFF_ECOLI iep swissprot:YGFF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGFF_ECOLI inforesidue swissprot:YGFF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGFF_ECOLI octanol swissprot:YGFF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGFF_ECOLI pepcoil swissprot:YGFF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGFF_ECOLI pepdigest swissprot:YGFF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGFF_ECOLI pepinfo swissprot:YGFF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGFF_ECOLI pepnet swissprot:YGFF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGFF_ECOLI pepstats swissprot:YGFF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGFF_ECOLI pepwheel swissprot:YGFF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGFF_ECOLI pepwindow swissprot:YGFF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGFF_ECOLI sigcleave swissprot:YGFF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGFF_ECOLI ## Database ID URL or Descriptions # AltName GRPE_ECOLI HSP-70 cofactor # AltName GRPE_ECOLI HSP24 # AltName GRPE_ECOLI Heat shock protein B25.3 # BioGrid 4260616 144 # CDD cd00446 GrpE # EcoGene EG10416 grpE # FUNCTION GRPE_ECOLI Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. {ECO 0000269|PubMed 15102842, ECO 0000269|PubMed 8890154}. # GO_component GO:0005737 cytoplasm; IDA:UniProtKB. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000774 adenyl-nucleotide exchange factor activity; IDA:EcoCyc. # GO_function GO:0051082 unfolded protein binding; IBA:GO_Central. # GO_process GO:0006457 protein folding; IEA:InterPro. # GO_process GO:0009408 response to heat; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0030234 enzyme regulator activity # GOslim_function GO:0051082 unfolded protein binding # GOslim_process GO:0006457 protein folding # GOslim_process GO:0006950 response to stress # Gene3D 2.30.22.10 -; 1. # Gene3D 3.90.20.20 -; 1. # HAMAP MF_01151 GrpE # INDUCTION GRPE_ECOLI By the sigma(32) subunit of RNA polymerase. # IntAct P09372 49 # InterPro IPR000740 GrpE # InterPro IPR009012 GrpE_head # InterPro IPR013805 GrpE_coiled_coil # KEGG_Brite ko03110 Chaperones and folding catalysts # Organism GRPE_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21237 PTHR21237 # PATRIC 32120625 VBIEscCol129921_2711 # PDB 1DKG X-ray; 2.80 A; A/B=1-197 # PIR S01240 S01240 # PRINTS PR00773 GRPEPROTEIN # PROSITE PS01071 GRPE # Pfam PF01025 GrpE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GRPE_ECOLI Protein GrpE # RefSeq NP_417104 NC_000913.3 # RefSeq WP_001393454 NZ_LN832404.1 # SIMILARITY Belongs to the GrpE family. {ECO 0000305}. # SUBCELLULAR LOCATION GRPE_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 9103205}. # SUPFAM SSF51064 SSF51064 # eggNOG COG0576 LUCA # eggNOG ENOG4105K90 Bacteria BLAST swissprot:GRPE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GRPE_ECOLI BioCyc ECOL316407:JW2594-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2594-MONOMER BioCyc EcoCyc:EG10416-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10416-MONOMER BioCyc MetaCyc:EG10416-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10416-MONOMER COG COG0576 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0576 DIP DIP-6141N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-6141N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/bbrc.2001.4567 http://dx.doi.org/10.1006/bbrc.2001.4567 DOI 10.1016/j.jmb.2004.03.074 http://dx.doi.org/10.1016/j.jmb.2004.03.074 DOI 10.1021/bi034416b http://dx.doi.org/10.1021/bi034416b DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.88.7.2874 http://dx.doi.org/10.1073/pnas.88.7.2874 DOI 10.1074/jbc.M300924200 http://dx.doi.org/10.1074/jbc.M300924200 DOI 10.1074/jbc.M403558200 http://dx.doi.org/10.1074/jbc.M403558200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/nar/16.15.7545 http://dx.doi.org/10.1093/nar/16.15.7545 DOI 10.1126/science.276.5311.431 http://dx.doi.org/10.1126/science.276.5311.431 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DisProt DP00103 http://www.disprot.org/protein.php?id=DP00103 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X07863 http://www.ebi.ac.uk/ena/data/view/X07863 EchoBASE EB0411 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0411 EcoGene EG10416 http://www.ecogene.org/geneInfo.php?eg_id=EG10416 EnsemblBacteria AAC75663 http://www.ensemblgenomes.org/id/AAC75663 EnsemblBacteria AAC75663 http://www.ensemblgenomes.org/id/AAC75663 EnsemblBacteria BAA16498 http://www.ensemblgenomes.org/id/BAA16498 EnsemblBacteria BAA16498 http://www.ensemblgenomes.org/id/BAA16498 EnsemblBacteria BAA16498 http://www.ensemblgenomes.org/id/BAA16498 EnsemblBacteria b2614 http://www.ensemblgenomes.org/id/b2614 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000774 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000774 GO_function GO:0051082 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051082 GO_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 GOslim_function GO:0051082 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051082 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 2.30.22.10 http://www.cathdb.info/version/latest/superfamily/2.30.22.10 Gene3D 3.90.20.20 http://www.cathdb.info/version/latest/superfamily/3.90.20.20 GeneID 947097 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947097 HAMAP MF_01151 http://hamap.expasy.org/unirule/MF_01151 HOGENOM HOG000252084 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000252084&db=HOGENOM6 InParanoid P09372 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P09372 IntAct P09372 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P09372* InterPro IPR000740 http://www.ebi.ac.uk/interpro/entry/IPR000740 InterPro IPR009012 http://www.ebi.ac.uk/interpro/entry/IPR009012 InterPro IPR013805 http://www.ebi.ac.uk/interpro/entry/IPR013805 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW2594 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2594 KEGG_Gene eco:b2614 http://www.genome.jp/dbget-bin/www_bget?eco:b2614 KEGG_Orthology KO:K03687 http://www.genome.jp/dbget-bin/www_bget?KO:K03687 MINT MINT-1225400 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1225400 OMA FANENIM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FANENIM PANTHER PTHR21237 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21237 PDB 1DKG http://www.ebi.ac.uk/pdbe-srv/view/entry/1DKG PDBsum 1DKG http://www.ebi.ac.uk/pdbsum/1DKG PRINTS PR00773 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00773 PROSITE PS01071 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01071 PSORT swissprot:GRPE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GRPE_ECOLI PSORT-B swissprot:GRPE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GRPE_ECOLI PSORT2 swissprot:GRPE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GRPE_ECOLI Pfam PF01025 http://pfam.xfam.org/family/PF01025 Phobius swissprot:GRPE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GRPE_ECOLI PhylomeDB P09372 http://phylomedb.org/?seqid=P09372 ProteinModelPortal P09372 http://www.proteinmodelportal.org/query/uniprot/P09372 PubMed 11401497 http://www.ncbi.nlm.nih.gov/pubmed/11401497 PubMed 12639955 http://www.ncbi.nlm.nih.gov/pubmed/12639955 PubMed 12885238 http://www.ncbi.nlm.nih.gov/pubmed/12885238 PubMed 15102842 http://www.ncbi.nlm.nih.gov/pubmed/15102842 PubMed 15136046 http://www.ncbi.nlm.nih.gov/pubmed/15136046 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1826368 http://www.ncbi.nlm.nih.gov/pubmed/1826368 PubMed 3045760 http://www.ncbi.nlm.nih.gov/pubmed/3045760 PubMed 8890154 http://www.ncbi.nlm.nih.gov/pubmed/8890154 PubMed 9103205 http://www.ncbi.nlm.nih.gov/pubmed/9103205 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417104 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417104 RefSeq WP_001393454 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001393454 SMR P09372 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P09372 STRING 511145.b2614 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2614&targetmode=cogs STRING COG0576 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0576&targetmode=cogs SUPFAM SSF51064 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51064 SWISS-2DPAGE P09372 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P09372 UniProtKB GRPE_ECOLI http://www.uniprot.org/uniprot/GRPE_ECOLI UniProtKB-AC P09372 http://www.uniprot.org/uniprot/P09372 charge swissprot:GRPE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GRPE_ECOLI eggNOG COG0576 http://eggnogapi.embl.de/nog_data/html/tree/COG0576 eggNOG ENOG4105K90 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K90 epestfind swissprot:GRPE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GRPE_ECOLI garnier swissprot:GRPE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GRPE_ECOLI helixturnhelix swissprot:GRPE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GRPE_ECOLI hmoment swissprot:GRPE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GRPE_ECOLI iep swissprot:GRPE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GRPE_ECOLI inforesidue swissprot:GRPE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GRPE_ECOLI octanol swissprot:GRPE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GRPE_ECOLI pepcoil swissprot:GRPE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GRPE_ECOLI pepdigest swissprot:GRPE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GRPE_ECOLI pepinfo swissprot:GRPE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GRPE_ECOLI pepnet swissprot:GRPE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GRPE_ECOLI pepstats swissprot:GRPE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GRPE_ECOLI pepwheel swissprot:GRPE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GRPE_ECOLI pepwindow swissprot:GRPE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GRPE_ECOLI sigcleave swissprot:GRPE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GRPE_ECOLI ## Database ID URL or Descriptions # BioGrid 4260808 166 # EcoGene EG11536 yidE # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0008324 cation transmembrane transporter activity; IEA:InterPro. # GO_function GO:0015459 potassium channel regulator activity; IEA:UniProtKB-HAMAP. # GO_process GO:0006813 potassium ion transport; IEA:InterPro. # GO_process GO:0043266 regulation of potassium ion transport; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # Gene3D 3.30.70.1450 -; 2. # HAMAP MF_01016 YidE # InterPro IPR006037 RCK_C # InterPro IPR006512 YidE_YbjL # InterPro IPR023018 Transpt_YidE_put # Organism YIDE_ECOLI Escherichia coli (strain K12) # PATRIC 32122863 VBIEscCol129921_3807 # PIR F65170 F65170 # PROSITE PS51202 RCK_C; 2 # Pfam PF02080 TrkA_C; 2 # Pfam PF06826 Asp-Al_Ex; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Putative transport protein YidE {ECO:0000255|HAMAP-Rule MF_01016} # RefSeq NP_418140 NC_000913.3 # RefSeq WP_001279752 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA62037.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the AAE transporter (TC 2.A.81) family. YidE subfamily. {ECO:0000255|HAMAP-Rule MF_01016}. # SIMILARITY Contains 2 RCK C-terminal domains. {ECO:0000255|HAMAP- Rule MF_01016}. # SUBCELLULAR LOCATION YIDE_ECOLI Cell membrane {ECO 0000255|HAMAP- Rule MF_01016}; Multi-pass membrane protein {ECO 0000255|HAMAP- Rule MF_01016}. # SUPFAM SSF116726 SSF116726; 2 # TIGRFAMs TIGR01625 YidE_YbjL_dupl; 2 # eggNOG COG2985 LUCA # eggNOG ENOG4105D0C Bacteria BLAST swissprot:YIDE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIDE_ECOLI BioCyc ECOL316407:JW3662-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3662-MONOMER BioCyc EcoCyc:EG11536-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11536-MONOMER COG COG2985 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2985 DIP DIP-12444N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12444N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M94104 http://www.ebi.ac.uk/ena/data/view/M94104 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1498 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1498 EcoGene EG11536 http://www.ecogene.org/geneInfo.php?eg_id=EG11536 EnsemblBacteria AAC76708 http://www.ensemblgenomes.org/id/AAC76708 EnsemblBacteria AAC76708 http://www.ensemblgenomes.org/id/AAC76708 EnsemblBacteria BAE77609 http://www.ensemblgenomes.org/id/BAE77609 EnsemblBacteria BAE77609 http://www.ensemblgenomes.org/id/BAE77609 EnsemblBacteria BAE77609 http://www.ensemblgenomes.org/id/BAE77609 EnsemblBacteria b3685 http://www.ensemblgenomes.org/id/b3685 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008324 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008324 GO_function GO:0015459 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015459 GO_process GO:0006813 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813 GO_process GO:0043266 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043266 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.30.70.1450 http://www.cathdb.info/version/latest/superfamily/3.30.70.1450 GeneID 948193 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948193 HAMAP MF_01016 http://hamap.expasy.org/unirule/MF_01016 HOGENOM HOG000013110 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000013110&db=HOGENOM6 InParanoid P60872 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P60872 IntAct P60872 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P60872* InterPro IPR006037 http://www.ebi.ac.uk/interpro/entry/IPR006037 InterPro IPR006512 http://www.ebi.ac.uk/interpro/entry/IPR006512 InterPro IPR023018 http://www.ebi.ac.uk/interpro/entry/IPR023018 KEGG_Gene ecj:JW3662 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3662 KEGG_Gene eco:b3685 http://www.genome.jp/dbget-bin/www_bget?eco:b3685 KEGG_Orthology KO:K07085 http://www.genome.jp/dbget-bin/www_bget?KO:K07085 MINT MINT-1257845 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1257845 OMA ELGDYLH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ELGDYLH PROSITE PS51202 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51202 PSORT swissprot:YIDE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIDE_ECOLI PSORT-B swissprot:YIDE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIDE_ECOLI PSORT2 swissprot:YIDE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIDE_ECOLI Pfam PF02080 http://pfam.xfam.org/family/PF02080 Pfam PF06826 http://pfam.xfam.org/family/PF06826 Phobius swissprot:YIDE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIDE_ECOLI PhylomeDB P60872 http://phylomedb.org/?seqid=P60872 ProteinModelPortal P60872 http://www.proteinmodelportal.org/query/uniprot/P60872 PubMed 1356969 http://www.ncbi.nlm.nih.gov/pubmed/1356969 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418140 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418140 RefSeq WP_001279752 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001279752 SMR P60872 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P60872 STRING 511145.b3685 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3685&targetmode=cogs STRING COG2985 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2985&targetmode=cogs SUPFAM SSF116726 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF116726 TIGRFAMs TIGR01625 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01625 UniProtKB YIDE_ECOLI http://www.uniprot.org/uniprot/YIDE_ECOLI UniProtKB-AC P60872 http://www.uniprot.org/uniprot/P60872 charge swissprot:YIDE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIDE_ECOLI eggNOG COG2985 http://eggnogapi.embl.de/nog_data/html/tree/COG2985 eggNOG ENOG4105D0C http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D0C epestfind swissprot:YIDE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIDE_ECOLI garnier swissprot:YIDE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIDE_ECOLI helixturnhelix swissprot:YIDE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIDE_ECOLI hmoment swissprot:YIDE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIDE_ECOLI iep swissprot:YIDE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIDE_ECOLI inforesidue swissprot:YIDE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIDE_ECOLI octanol swissprot:YIDE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIDE_ECOLI pepcoil swissprot:YIDE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIDE_ECOLI pepdigest swissprot:YIDE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIDE_ECOLI pepinfo swissprot:YIDE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIDE_ECOLI pepnet swissprot:YIDE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIDE_ECOLI pepstats swissprot:YIDE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIDE_ECOLI pepwheel swissprot:YIDE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIDE_ECOLI pepwindow swissprot:YIDE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIDE_ECOLI sigcleave swissprot:YIDE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIDE_ECOLI ## Database ID URL or Descriptions # EcoGene EG14461 yojO # Organism YOJO_ECOLI Escherichia coli (strain K12) # Proteomes UP000000625 Chromosome # RecName YOJO_ECOLI Uncharacterized protein YojO # RefSeq WP_001310984 NZ_LN832404.1 # SIMILARITY Belongs to the YojO family. {ECO 0000305}. BLAST swissprot:YOJO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YOJO_ECOLI BioCyc EcoCyc:MONOMER0-2823 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2823 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14461 http://www.ecogene.org/geneInfo.php?eg_id=EG14461 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv HOGENOM HOG000051706 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000051706&db=HOGENOM6 OMA HTYIAIN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HTYIAIN PSORT swissprot:YOJO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YOJO_ECOLI PSORT-B swissprot:YOJO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YOJO_ECOLI PSORT2 swissprot:YOJO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YOJO_ECOLI Phobius swissprot:YOJO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YOJO_ECOLI ProteinModelPortal A5A619 http://www.proteinmodelportal.org/query/uniprot/A5A619 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001310984 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001310984 STRING 511145.b4604 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4604&targetmode=cogs UniProtKB YOJO_ECOLI http://www.uniprot.org/uniprot/YOJO_ECOLI UniProtKB-AC A5A619 http://www.uniprot.org/uniprot/A5A619 charge swissprot:YOJO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YOJO_ECOLI epestfind swissprot:YOJO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YOJO_ECOLI garnier swissprot:YOJO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YOJO_ECOLI helixturnhelix swissprot:YOJO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YOJO_ECOLI hmoment swissprot:YOJO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YOJO_ECOLI iep swissprot:YOJO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YOJO_ECOLI inforesidue swissprot:YOJO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YOJO_ECOLI octanol swissprot:YOJO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YOJO_ECOLI pepcoil swissprot:YOJO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YOJO_ECOLI pepdigest swissprot:YOJO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YOJO_ECOLI pepinfo swissprot:YOJO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YOJO_ECOLI pepnet swissprot:YOJO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YOJO_ECOLI pepstats swissprot:YOJO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YOJO_ECOLI pepwheel swissprot:YOJO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YOJO_ECOLI pepwindow swissprot:YOJO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YOJO_ECOLI sigcleave swissprot:YOJO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YOJO_ECOLI ## Database ID URL or Descriptions # AltName ALKB_ECOLI Alkylated DNA repair protein AlkB # AltName ALKB_ECOLI DNA oxidative demethylase AlkB # BRENDA 1.14.11.33 2026 # BioGrid 4261918 29 # CATALYTIC ACTIVITY ALKB_ECOLI DNA-base-CH(3) + 2-oxoglutarate + O(2) = DNA- base + formaldehyde + succinate + CO(2). {ECO 0000269|PubMed 12226668, ECO 0000269|PubMed 20084272, ECO 0000269|PubMed 21068844}. # COFACTOR ALKB_ECOLI Name=Fe(2+); Xref=ChEBI CHEBI 29033; Evidence={ECO 0000255|PROSITE-ProRule PRU00805, ECO 0000269|PubMed 16482161, ECO 0000269|PubMed 19706517, ECO 0000269|PubMed 20084272, ECO 0000269|PubMed 21068844}; Note=Binds 1 Fe(2+) ion per subunit. {ECO 0000255|PROSITE- ProRule PRU00805, ECO 0000269|PubMed 16482161, ECO 0000269|PubMed 19706517, ECO 0000269|PubMed 20084272, ECO 0000269|PubMed 21068844}; # EcoGene EG10037 alkB # FUNCTION ALKB_ECOLI Dioxygenase that repairs alkylated DNA and RNA containing 3-methylcytosine or 1-methyladenine by oxidative demethylation. Has highest activity towards 3-methylcytosine. Has lower activity towards alkylated DNA containing ethenoadenine, and no detectable activity towards 1-methylguanine or 3-methylthymine. Accepts double-stranded and single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron. Provides extensive resistance to alkylating agents such as MMS and DMS (SN2 agents), but not to MMNG and MNU (SN1 agents). {ECO 0000269|PubMed 12226668, ECO 0000269|PubMed 12594517, ECO 0000269|PubMed 16482161, ECO 0000269|PubMed 19706517, ECO 0000269|PubMed 20084272, ECO 0000269|PubMed 21068844}. # GO_function GO:0008198 ferrous iron binding; IDA:UniProtKB. # GO_function GO:0035515 oxidative RNA demethylase activity; IDA:UniProtKB. # GO_function GO:0043734 DNA-N1-methyladenine dioxygenase activity; IDA:UniProtKB. # GO_function GO:0051213 dioxygenase activity; IDA:EcoCyc. # GO_function GO:0051747 cytosine C-5 DNA demethylase activity; IDA:UniProtKB. # GO_function GO:0103053 1-ethyladenine demethylase activity; IEA:UniProtKB-EC. # GO_process GO:0006281 DNA repair; IMP:EcoCyc. # GO_process GO:0006307 DNA dealkylation involved in DNA repair; IDA:UniProtKB. # GO_process GO:0035552 oxidative single-stranded DNA demethylation; IDA:UniProtKB. # GO_process GO:0035553 oxidative single-stranded RNA demethylation; IDA:UniProtKB. # GO_process GO:0042245 RNA repair; IDA:UniProtKB. # GO_process GO:0070989 oxidative demethylation; IDA:UniProtKB. # GO_process GO:0080111 DNA demethylation; IDA:UniProtKB. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 2.60.120.590 -; 1. # IntAct P05050 12 # InterPro IPR004574 Alkb # InterPro IPR005123 Oxoglu/Fe-dep_dioxygenase # InterPro IPR027450 AlkB-like # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # Organism ALKB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR16557 PTHR16557; 2 # PATRIC 32119783 VBIEscCol129921_2301 # PDB 2FD8 X-ray; 2.30 A; A=12-216 # PDB 2FDF X-ray; 2.10 A; A=12-216 # PDB 2FDG X-ray; 2.20 A; A=12-216 # PDB 2FDH X-ray; 2.10 A; A=12-216 # PDB 2FDI X-ray; 1.80 A; A=12-216 # PDB 2FDJ X-ray; 2.10 A; A=12-216 # PDB 2FDK X-ray; 2.30 A; A=12-216 # PDB 3BI3 X-ray; 1.90 A; A=13-213 # PDB 3BIE X-ray; 1.68 A; A=13-214 # PDB 3BKZ X-ray; 1.65 A; A=14-214 # PDB 3I2O X-ray; 1.70 A; A=12-216 # PDB 3I3M X-ray; 1.50 A; A=12-216 # PDB 3I3Q X-ray; 1.40 A; A/B=12-216 # PDB 3I49 X-ray; 1.60 A; A=12-216 # PDB 3KHB X-ray; 2.90 A; A/B=1-216 # PDB 3KHC X-ray; 2.20 A; A/B=1-216 # PDB 3O1M X-ray; 1.75 A; A=12-216 # PDB 3O1O X-ray; 1.92 A; A=12-216 # PDB 3O1P X-ray; 1.51 A; A=12-216 # PDB 3O1R X-ray; 1.77 A; A=12-216 # PDB 3O1S X-ray; 1.58 A; A=12-216 # PDB 3O1T X-ray; 1.48 A; A=12-216 # PDB 3O1U X-ray; 1.54 A; A=12-216 # PDB 3O1V X-ray; 1.90 A; A=12-216 # PDB 3T3Y X-ray; 2.00 A; A=12-216 # PDB 3T4H X-ray; 1.65 A; B=12-216 # PDB 3T4V X-ray; 1.73 A; A=12-216 # PDB 4JHT X-ray; 1.18 A; A=12-216 # PDB 4NID X-ray; 1.58 A; A=12-216 # PDB 4NIG X-ray; 1.52 A; A=12-216 # PDB 4NIH X-ray; 1.37 A; A=12-216 # PDB 4NII X-ray; 1.62 A; A=12-216 # PDB 4RFR X-ray; 1.50 A; B=14-216 # PDB 4ZHN X-ray; 1.33 A; A=12-216 # PIR A24605 BVECKB # PROSITE PS51471 FE2OG_OXY # Pfam PF13532 2OG-FeII_Oxy_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ALKB_ECOLI Alpha-ketoglutarate-dependent dioxygenase AlkB # RefSeq NP_416716 NC_000913.3 # RefSeq WP_000884971 NZ_LN832404.1 # SIMILARITY Belongs to the alkB family. {ECO 0000305}. # SIMILARITY Contains 1 Fe2OG dioxygenase domain. {ECO:0000255|PROSITE-ProRule PRU00805}. # TIGRFAMs TIGR00568 alkb # eggNOG COG3145 LUCA # eggNOG ENOG4105CF1 Bacteria BLAST swissprot:ALKB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ALKB_ECOLI BioCyc ECOL316407:JW2200-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2200-MONOMER BioCyc EcoCyc:EG10037-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10037-MONOMER BioCyc MetaCyc:EG10037-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10037-MONOMER COG COG3145 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3145 DIP DIP-9085N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9085N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature01048 http://dx.doi.org/10.1038/nature01048 DOI 10.1038/nature01363 http://dx.doi.org/10.1038/nature01363 DOI 10.1038/nature04561 http://dx.doi.org/10.1038/nature04561 DOI 10.1038/nature06889 http://dx.doi.org/10.1038/nature06889 DOI 10.1038/nature09497 http://dx.doi.org/10.1038/nature09497 DOI 10.1073/pnas.0812938106 http://dx.doi.org/10.1073/pnas.0812938106 DOI 10.1073/pnas.82.9.2688 http://dx.doi.org/10.1073/pnas.82.9.2688 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pone.0008680 http://dx.doi.org/10.1371/journal.pone.0008680 EC_number EC:1.14.11.33 http://www.genome.jp/dbget-bin/www_bget?EC:1.14.11.33 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J02607 http://www.ebi.ac.uk/ena/data/view/J02607 EMBL M10315 http://www.ebi.ac.uk/ena/data/view/M10315 EMBL U00008 http://www.ebi.ac.uk/ena/data/view/U00008 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.14.11.33 http://enzyme.expasy.org/EC/1.14.11.33 EchoBASE EB0036 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0036 EcoGene EG10037 http://www.ecogene.org/geneInfo.php?eg_id=EG10037 EnsemblBacteria AAC75272 http://www.ensemblgenomes.org/id/AAC75272 EnsemblBacteria AAC75272 http://www.ensemblgenomes.org/id/AAC75272 EnsemblBacteria BAA15995 http://www.ensemblgenomes.org/id/BAA15995 EnsemblBacteria BAA15995 http://www.ensemblgenomes.org/id/BAA15995 EnsemblBacteria BAA15995 http://www.ensemblgenomes.org/id/BAA15995 EnsemblBacteria b2212 http://www.ensemblgenomes.org/id/b2212 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008198 GO_function GO:0035515 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035515 GO_function GO:0043734 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043734 GO_function GO:0051213 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051213 GO_function GO:0051747 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051747 GO_function GO:0103053 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0103053 GO_process GO:0006281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006281 GO_process GO:0006307 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006307 GO_process GO:0035552 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035552 GO_process GO:0035553 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035553 GO_process GO:0042245 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042245 GO_process GO:0070989 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070989 GO_process GO:0080111 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0080111 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 2.60.120.590 http://www.cathdb.info/version/latest/superfamily/2.60.120.590 GeneID 946708 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946708 HOGENOM HOG000122276 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122276&db=HOGENOM6 InParanoid P05050 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P05050 IntAct P05050 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P05050* IntEnz 1.14.11.33 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.14.11.33 InterPro IPR004574 http://www.ebi.ac.uk/interpro/entry/IPR004574 InterPro IPR005123 http://www.ebi.ac.uk/interpro/entry/IPR005123 InterPro IPR027450 http://www.ebi.ac.uk/interpro/entry/IPR027450 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW2200 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2200 KEGG_Gene eco:b2212 http://www.genome.jp/dbget-bin/www_bget?eco:b2212 KEGG_Orthology KO:K03919 http://www.genome.jp/dbget-bin/www_bget?KO:K03919 MINT MINT-1258339 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1258339 OMA FEMSVAL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FEMSVAL PANTHER PTHR16557 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16557 PDB 2FD8 http://www.ebi.ac.uk/pdbe-srv/view/entry/2FD8 PDB 2FDF http://www.ebi.ac.uk/pdbe-srv/view/entry/2FDF PDB 2FDG http://www.ebi.ac.uk/pdbe-srv/view/entry/2FDG PDB 2FDH http://www.ebi.ac.uk/pdbe-srv/view/entry/2FDH PDB 2FDI http://www.ebi.ac.uk/pdbe-srv/view/entry/2FDI PDB 2FDJ http://www.ebi.ac.uk/pdbe-srv/view/entry/2FDJ PDB 2FDK http://www.ebi.ac.uk/pdbe-srv/view/entry/2FDK PDB 3BI3 http://www.ebi.ac.uk/pdbe-srv/view/entry/3BI3 PDB 3BIE http://www.ebi.ac.uk/pdbe-srv/view/entry/3BIE PDB 3BKZ http://www.ebi.ac.uk/pdbe-srv/view/entry/3BKZ PDB 3I2O http://www.ebi.ac.uk/pdbe-srv/view/entry/3I2O PDB 3I3M http://www.ebi.ac.uk/pdbe-srv/view/entry/3I3M PDB 3I3Q http://www.ebi.ac.uk/pdbe-srv/view/entry/3I3Q PDB 3I49 http://www.ebi.ac.uk/pdbe-srv/view/entry/3I49 PDB 3KHB http://www.ebi.ac.uk/pdbe-srv/view/entry/3KHB PDB 3KHC http://www.ebi.ac.uk/pdbe-srv/view/entry/3KHC PDB 3O1M http://www.ebi.ac.uk/pdbe-srv/view/entry/3O1M PDB 3O1O http://www.ebi.ac.uk/pdbe-srv/view/entry/3O1O PDB 3O1P http://www.ebi.ac.uk/pdbe-srv/view/entry/3O1P PDB 3O1R http://www.ebi.ac.uk/pdbe-srv/view/entry/3O1R PDB 3O1S http://www.ebi.ac.uk/pdbe-srv/view/entry/3O1S PDB 3O1T http://www.ebi.ac.uk/pdbe-srv/view/entry/3O1T PDB 3O1U http://www.ebi.ac.uk/pdbe-srv/view/entry/3O1U PDB 3O1V http://www.ebi.ac.uk/pdbe-srv/view/entry/3O1V PDB 3T3Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3T3Y PDB 3T4H http://www.ebi.ac.uk/pdbe-srv/view/entry/3T4H PDB 3T4V http://www.ebi.ac.uk/pdbe-srv/view/entry/3T4V PDB 4JHT http://www.ebi.ac.uk/pdbe-srv/view/entry/4JHT PDB 4NID http://www.ebi.ac.uk/pdbe-srv/view/entry/4NID PDB 4NIG http://www.ebi.ac.uk/pdbe-srv/view/entry/4NIG PDB 4NIH http://www.ebi.ac.uk/pdbe-srv/view/entry/4NIH PDB 4NII http://www.ebi.ac.uk/pdbe-srv/view/entry/4NII PDB 4RFR http://www.ebi.ac.uk/pdbe-srv/view/entry/4RFR PDB 4ZHN http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZHN PDBsum 2FD8 http://www.ebi.ac.uk/pdbsum/2FD8 PDBsum 2FDF http://www.ebi.ac.uk/pdbsum/2FDF PDBsum 2FDG http://www.ebi.ac.uk/pdbsum/2FDG PDBsum 2FDH http://www.ebi.ac.uk/pdbsum/2FDH PDBsum 2FDI http://www.ebi.ac.uk/pdbsum/2FDI PDBsum 2FDJ http://www.ebi.ac.uk/pdbsum/2FDJ PDBsum 2FDK http://www.ebi.ac.uk/pdbsum/2FDK PDBsum 3BI3 http://www.ebi.ac.uk/pdbsum/3BI3 PDBsum 3BIE http://www.ebi.ac.uk/pdbsum/3BIE PDBsum 3BKZ http://www.ebi.ac.uk/pdbsum/3BKZ PDBsum 3I2O http://www.ebi.ac.uk/pdbsum/3I2O PDBsum 3I3M http://www.ebi.ac.uk/pdbsum/3I3M PDBsum 3I3Q http://www.ebi.ac.uk/pdbsum/3I3Q PDBsum 3I49 http://www.ebi.ac.uk/pdbsum/3I49 PDBsum 3KHB http://www.ebi.ac.uk/pdbsum/3KHB PDBsum 3KHC http://www.ebi.ac.uk/pdbsum/3KHC PDBsum 3O1M http://www.ebi.ac.uk/pdbsum/3O1M PDBsum 3O1O http://www.ebi.ac.uk/pdbsum/3O1O PDBsum 3O1P http://www.ebi.ac.uk/pdbsum/3O1P PDBsum 3O1R http://www.ebi.ac.uk/pdbsum/3O1R PDBsum 3O1S http://www.ebi.ac.uk/pdbsum/3O1S PDBsum 3O1T http://www.ebi.ac.uk/pdbsum/3O1T PDBsum 3O1U http://www.ebi.ac.uk/pdbsum/3O1U PDBsum 3O1V http://www.ebi.ac.uk/pdbsum/3O1V PDBsum 3T3Y http://www.ebi.ac.uk/pdbsum/3T3Y PDBsum 3T4H http://www.ebi.ac.uk/pdbsum/3T4H PDBsum 3T4V http://www.ebi.ac.uk/pdbsum/3T4V PDBsum 4JHT http://www.ebi.ac.uk/pdbsum/4JHT PDBsum 4NID http://www.ebi.ac.uk/pdbsum/4NID PDBsum 4NIG http://www.ebi.ac.uk/pdbsum/4NIG PDBsum 4NIH http://www.ebi.ac.uk/pdbsum/4NIH PDBsum 4NII http://www.ebi.ac.uk/pdbsum/4NII PDBsum 4RFR http://www.ebi.ac.uk/pdbsum/4RFR PDBsum 4ZHN http://www.ebi.ac.uk/pdbsum/4ZHN PROSITE PS51471 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51471 PSORT swissprot:ALKB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ALKB_ECOLI PSORT-B swissprot:ALKB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ALKB_ECOLI PSORT2 swissprot:ALKB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ALKB_ECOLI Pfam PF13532 http://pfam.xfam.org/family/PF13532 Phobius swissprot:ALKB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ALKB_ECOLI PhylomeDB P05050 http://phylomedb.org/?seqid=P05050 ProteinModelPortal P05050 http://www.proteinmodelportal.org/query/uniprot/P05050 PubMed 12226668 http://www.ncbi.nlm.nih.gov/pubmed/12226668 PubMed 12594517 http://www.ncbi.nlm.nih.gov/pubmed/12594517 PubMed 16482161 http://www.ncbi.nlm.nih.gov/pubmed/16482161 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18432238 http://www.ncbi.nlm.nih.gov/pubmed/18432238 PubMed 19706517 http://www.ncbi.nlm.nih.gov/pubmed/19706517 PubMed 20084272 http://www.ncbi.nlm.nih.gov/pubmed/20084272 PubMed 21068844 http://www.ncbi.nlm.nih.gov/pubmed/21068844 PubMed 3536913 http://www.ncbi.nlm.nih.gov/pubmed/3536913 PubMed 3887409 http://www.ncbi.nlm.nih.gov/pubmed/3887409 PubMed 7928996 http://www.ncbi.nlm.nih.gov/pubmed/7928996 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416716 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416716 RefSeq WP_000884971 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000884971 SMR P05050 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P05050 STRING 511145.b2212 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2212&targetmode=cogs STRING COG3145 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3145&targetmode=cogs TIGRFAMs TIGR00568 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00568 UniProtKB ALKB_ECOLI http://www.uniprot.org/uniprot/ALKB_ECOLI UniProtKB-AC P05050 http://www.uniprot.org/uniprot/P05050 charge swissprot:ALKB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ALKB_ECOLI eggNOG COG3145 http://eggnogapi.embl.de/nog_data/html/tree/COG3145 eggNOG ENOG4105CF1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CF1 epestfind swissprot:ALKB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ALKB_ECOLI garnier swissprot:ALKB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ALKB_ECOLI helixturnhelix swissprot:ALKB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ALKB_ECOLI hmoment swissprot:ALKB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ALKB_ECOLI iep swissprot:ALKB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ALKB_ECOLI inforesidue swissprot:ALKB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ALKB_ECOLI octanol swissprot:ALKB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ALKB_ECOLI pepcoil swissprot:ALKB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ALKB_ECOLI pepdigest swissprot:ALKB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ALKB_ECOLI pepinfo swissprot:ALKB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ALKB_ECOLI pepnet swissprot:ALKB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ALKB_ECOLI pepstats swissprot:ALKB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ALKB_ECOLI pepwheel swissprot:ALKB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ALKB_ECOLI pepwindow swissprot:ALKB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ALKB_ECOLI sigcleave swissprot:ALKB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ALKB_ECOLI ## Database ID URL or Descriptions # BRENDA 1.3.5 2026 # BioGrid 4260883 163 # CATALYTIC ACTIVITY Succinate + a quinone = fumarate + a quinol. {ECO:0000269|PubMed 11850430}. # COFACTOR Name=FAD; Xref=ChEBI:CHEBI 57692; Note=Binds 1 FAD covalently per subunit.; # DrugBank DB00730 Thiabendazole # EcoGene EG10330 frdA # FUNCTION FRDA_ECOLI Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_component GO:0045284 plasma membrane fumarate reductase complex; IDA:EcoCyc. # GO_function GO:0000104 succinate dehydrogenase activity; IDA:EcoCyc. # GO_function GO:0009055 electron carrier activity; IDA:EcoCyc. # GO_function GO:0071949 FAD binding; IDA:EcoCyc. # GO_process GO:0006113 fermentation; IMP:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0009061 anaerobic respiration; IMP:EcoCyc. # GO_process GO:0022900 electron transport chain; IEA:InterPro. # GO_process GO:0044780 bacterial-type flagellum assembly; IMP:EcoCyc. # GO_process GO:0071973 bacterial-type flagellum-dependent cell motility; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0006950 response to stress # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0048870 cell motility # Gene3D 1.20.58.100 -; 1. # Gene3D 3.50.50.60 -; 2. # Gene3D 3.90.700.10 -; 1. # INTERACTION FRDA_ECOLI P0AC47 frdB; NbExp=4; IntAct=EBI-550480, EBI-906724; # IntAct P00363 14 # InterPro IPR003952 FRD_SDH_FAD_BS # InterPro IPR003953 FAD-binding_2 # InterPro IPR005884 Fum_red_fp # InterPro IPR014006 Succ_Dhase_FrdA_Gneg # InterPro IPR015939 Fum_Rdtase/Succ_DH_flav-like_C # InterPro IPR023753 FAD/NAD-binding_dom # InterPro IPR027477 Succ_DH/fumarate_Rdtase_cat # InterPro IPR030664 SdhA/FrdA/AprA # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00020 Citrate cycle (TCA cycle) # KEGG_Pathway ko00190 Oxidative phosphorylation # KEGG_Pathway ko00623 Toluene degradation # KEGG_Pathway ko00650 Butanoate metabolism # KEGG_Pathway ko00720 Carbon fixation pathways in prokaryotes # KEGG_Pathway ko02020 Two-component system # Organism FRDA_ECOLI Escherichia coli (strain K12) # PATRIC 32123881 VBIEscCol129921_4288 # PDB 1KF6 X-ray; 2.70 A; A/M=1-602 # PDB 1KFY X-ray; 3.60 A; A/M=1-602 # PDB 1L0V X-ray; 3.30 A; A/M=1-602 # PDB 2B76 X-ray; 3.30 A; A/M=1-602 # PDB 3CIR X-ray; 3.65 A; A/M=1-602 # PDB 3P4P X-ray; 2.80 A; A/M=1-577 # PDB 3P4Q X-ray; 3.35 A; A/M=1-577 # PDB 3P4R X-ray; 3.05 A; A/M=1-577 # PDB 3P4S X-ray; 3.10 A; A/M=1-577 # PDB 4KX6 X-ray; 2.95 A; A/M=1-577 # PIR A00376 RDECFF # PIRSF PIRSF000171 SDHA_APRA_LASPO # PROSITE PS00504 FRD_SDH_FAD_BINDING # Pfam PF00890 FAD_binding_2 # Pfam PF02910 Succ_DH_flav_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FRDA_ECOLI Fumarate reductase flavoprotein subunit # RefSeq NP_418578 NC_000913.3 # RefSeq WP_001192973 NZ_LN832404.1 # SIMILARITY Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. {ECO 0000305}. # SUBUNIT Fumarate dehydrogenase forms part of an enzyme complex containing four subunits a flavoprotein, an iron-sulfur, and two hydrophobic anchor proteins. # SUPFAM SSF46977 SSF46977 # SUPFAM SSF51905 SSF51905; 2 # SUPFAM SSF56425 SSF56425 # TIGRFAMs TIGR01176 fum_red_Fp # TIGRFAMs TIGR01812 sdhA_frdA_Gneg # eggNOG COG1053 LUCA # eggNOG ENOG4105C00 Bacteria BLAST swissprot:FRDA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FRDA_ECOLI BioCyc ECOL316407:JW4115-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4115-MONOMER BioCyc EcoCyc:FUM-FLAVO http://biocyc.org/getid?id=EcoCyc:FUM-FLAVO BioCyc MetaCyc:FUM-FLAVO http://biocyc.org/getid?id=MetaCyc:FUM-FLAVO COG COG1053 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1053 DIP DIP-9681N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9681N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.96.22.12412 http://dx.doi.org/10.1073/pnas.96.22.12412 DOI 10.1074/jbc.M200815200 http://dx.doi.org/10.1074/jbc.M200815200 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1126/science.284.5422.1961 http://dx.doi.org/10.1126/science.284.5422.1961 DrugBank DB00730 http://www.drugbank.ca/drugs/DB00730 EC_number EC:1.3.5.4 http://www.genome.jp/dbget-bin/www_bget?EC:1.3.5.4 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01611 http://www.ebi.ac.uk/ena/data/view/J01611 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 1.3.5.4 http://enzyme.expasy.org/EC/1.3.5.4 EchoBASE EB0326 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0326 EcoGene EG10330 http://www.ecogene.org/geneInfo.php?eg_id=EG10330 EnsemblBacteria AAC77114 http://www.ensemblgenomes.org/id/AAC77114 EnsemblBacteria AAC77114 http://www.ensemblgenomes.org/id/AAC77114 EnsemblBacteria BAE78158 http://www.ensemblgenomes.org/id/BAE78158 EnsemblBacteria BAE78158 http://www.ensemblgenomes.org/id/BAE78158 EnsemblBacteria BAE78158 http://www.ensemblgenomes.org/id/BAE78158 EnsemblBacteria b4154 http://www.ensemblgenomes.org/id/b4154 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0045284 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045284 GO_function GO:0000104 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000104 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0071949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071949 GO_process GO:0006113 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006113 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0009061 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009061 GO_process GO:0022900 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022900 GO_process GO:0044780 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044780 GO_process GO:0071973 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071973 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 Gene3D 1.20.58.100 http://www.cathdb.info/version/latest/superfamily/1.20.58.100 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 Gene3D 3.90.700.10 http://www.cathdb.info/version/latest/superfamily/3.90.700.10 GeneID 948667 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948667 HOGENOM HOG000160475 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000160475&db=HOGENOM6 InParanoid P00363 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00363 IntAct P00363 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00363* IntEnz 1.3.5.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.3.5.4 InterPro IPR003952 http://www.ebi.ac.uk/interpro/entry/IPR003952 InterPro IPR003953 http://www.ebi.ac.uk/interpro/entry/IPR003953 InterPro IPR005884 http://www.ebi.ac.uk/interpro/entry/IPR005884 InterPro IPR014006 http://www.ebi.ac.uk/interpro/entry/IPR014006 InterPro IPR015939 http://www.ebi.ac.uk/interpro/entry/IPR015939 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 InterPro IPR027477 http://www.ebi.ac.uk/interpro/entry/IPR027477 InterPro IPR030664 http://www.ebi.ac.uk/interpro/entry/IPR030664 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4115 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4115 KEGG_Gene eco:b4154 http://www.genome.jp/dbget-bin/www_bget?eco:b4154 KEGG_Orthology KO:K00244 http://www.genome.jp/dbget-bin/www_bget?KO:K00244 KEGG_Pathway ko00020 http://www.genome.jp/kegg-bin/show_pathway?ko00020 KEGG_Pathway ko00190 http://www.genome.jp/kegg-bin/show_pathway?ko00190 KEGG_Pathway ko00623 http://www.genome.jp/kegg-bin/show_pathway?ko00623 KEGG_Pathway ko00650 http://www.genome.jp/kegg-bin/show_pathway?ko00650 KEGG_Pathway ko00720 http://www.genome.jp/kegg-bin/show_pathway?ko00720 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 KEGG_Reaction rn:R00408 http://www.genome.jp/dbget-bin/www_bget?rn:R00408 KEGG_Reaction rn:R00412 http://www.genome.jp/dbget-bin/www_bget?rn:R00412 MINT MINT-1310079 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1310079 OMA AAPSIIH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AAPSIIH PDB 1KF6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1KF6 PDB 1KFY http://www.ebi.ac.uk/pdbe-srv/view/entry/1KFY PDB 1L0V http://www.ebi.ac.uk/pdbe-srv/view/entry/1L0V PDB 2B76 http://www.ebi.ac.uk/pdbe-srv/view/entry/2B76 PDB 3CIR http://www.ebi.ac.uk/pdbe-srv/view/entry/3CIR PDB 3P4P http://www.ebi.ac.uk/pdbe-srv/view/entry/3P4P PDB 3P4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/3P4Q PDB 3P4R http://www.ebi.ac.uk/pdbe-srv/view/entry/3P4R PDB 3P4S http://www.ebi.ac.uk/pdbe-srv/view/entry/3P4S PDB 4KX6 http://www.ebi.ac.uk/pdbe-srv/view/entry/4KX6 PDBsum 1KF6 http://www.ebi.ac.uk/pdbsum/1KF6 PDBsum 1KFY http://www.ebi.ac.uk/pdbsum/1KFY PDBsum 1L0V http://www.ebi.ac.uk/pdbsum/1L0V PDBsum 2B76 http://www.ebi.ac.uk/pdbsum/2B76 PDBsum 3CIR http://www.ebi.ac.uk/pdbsum/3CIR PDBsum 3P4P http://www.ebi.ac.uk/pdbsum/3P4P PDBsum 3P4Q http://www.ebi.ac.uk/pdbsum/3P4Q PDBsum 3P4R http://www.ebi.ac.uk/pdbsum/3P4R PDBsum 3P4S http://www.ebi.ac.uk/pdbsum/3P4S PDBsum 4KX6 http://www.ebi.ac.uk/pdbsum/4KX6 PROSITE PS00504 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00504 PSORT swissprot:FRDA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FRDA_ECOLI PSORT-B swissprot:FRDA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FRDA_ECOLI PSORT2 swissprot:FRDA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FRDA_ECOLI Pfam PF00890 http://pfam.xfam.org/family/PF00890 Pfam PF02910 http://pfam.xfam.org/family/PF02910 Phobius swissprot:FRDA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FRDA_ECOLI PhylomeDB P00363 http://phylomedb.org/?seqid=P00363 ProteinModelPortal P00363 http://www.proteinmodelportal.org/query/uniprot/P00363 PubMed 10373108 http://www.ncbi.nlm.nih.gov/pubmed/10373108 PubMed 10535936 http://www.ncbi.nlm.nih.gov/pubmed/10535936 PubMed 11850430 http://www.ncbi.nlm.nih.gov/pubmed/11850430 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1856194 http://www.ncbi.nlm.nih.gov/pubmed/1856194 PubMed 2668268 http://www.ncbi.nlm.nih.gov/pubmed/2668268 PubMed 7037404 http://www.ncbi.nlm.nih.gov/pubmed/7037404 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_418578 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418578 RefSeq WP_001192973 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001192973 SMR P00363 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00363 STRING 511145.b4154 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4154&targetmode=cogs STRING COG1053 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1053&targetmode=cogs SUPFAM SSF46977 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46977 SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 SUPFAM SSF56425 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56425 TIGRFAMs TIGR01176 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01176 TIGRFAMs TIGR01812 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01812 UniProtKB FRDA_ECOLI http://www.uniprot.org/uniprot/FRDA_ECOLI UniProtKB-AC P00363 http://www.uniprot.org/uniprot/P00363 charge swissprot:FRDA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FRDA_ECOLI eggNOG COG1053 http://eggnogapi.embl.de/nog_data/html/tree/COG1053 eggNOG ENOG4105C00 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C00 epestfind swissprot:FRDA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FRDA_ECOLI garnier swissprot:FRDA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FRDA_ECOLI helixturnhelix swissprot:FRDA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FRDA_ECOLI hmoment swissprot:FRDA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FRDA_ECOLI iep swissprot:FRDA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FRDA_ECOLI inforesidue swissprot:FRDA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FRDA_ECOLI octanol swissprot:FRDA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FRDA_ECOLI pepcoil swissprot:FRDA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FRDA_ECOLI pepdigest swissprot:FRDA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FRDA_ECOLI pepinfo swissprot:FRDA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FRDA_ECOLI pepnet swissprot:FRDA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FRDA_ECOLI pepstats swissprot:FRDA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FRDA_ECOLI pepwheel swissprot:FRDA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FRDA_ECOLI pepwindow swissprot:FRDA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FRDA_ECOLI sigcleave swissprot:FRDA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FRDA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262526 3 # CDD cd06170 LuxR_C_like # EcoGene EG12246 yhjB # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; ISS:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # INTERACTION YHJB_ECOLI P0A6F5 groL; NbExp=3; IntAct=EBI-542016, EBI-543750; # IntAct P37640 9 # InterPro IPR000792 Tscrpt_reg_LuxR_C # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR016032 Sig_transdc_resp-reg_C-effctor # Organism YHJB_ECOLI Escherichia coli (strain K12) # PATRIC 32122502 VBIEscCol129921_3629 # PIR S47740 S47740 # PRINTS PR00038 HTHLUXR # PROSITE PS00622 HTH_LUXR_1 # PROSITE PS50043 HTH_LUXR_2 # Pfam PF00196 GerE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHJB_ECOLI Putative HTH-type transcriptional regulator YhjB # RefSeq NP_417977 NC_000913.3 # RefSeq WP_001167676 NZ_LN832404.1 # SIMILARITY Contains 1 HTH luxR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00411}. # SMART SM00421 HTH_LUXR # SUPFAM SSF46894 SSF46894 # eggNOG ENOG4106S2D Bacteria # eggNOG ENOG4111IKU LUCA BLAST swissprot:YHJB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHJB_ECOLI BioCyc ECOL316407:JW3488-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3488-MONOMER BioCyc EcoCyc:EG12246-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12246-MONOMER DIP DIP-12377N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12377N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2157 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2157 EcoGene EG12246 http://www.ecogene.org/geneInfo.php?eg_id=EG12246 EnsemblBacteria AAC76545 http://www.ensemblgenomes.org/id/AAC76545 EnsemblBacteria AAC76545 http://www.ensemblgenomes.org/id/AAC76545 EnsemblBacteria BAE77774 http://www.ensemblgenomes.org/id/BAE77774 EnsemblBacteria BAE77774 http://www.ensemblgenomes.org/id/BAE77774 EnsemblBacteria BAE77774 http://www.ensemblgenomes.org/id/BAE77774 EnsemblBacteria b3520 http://www.ensemblgenomes.org/id/b3520 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 948036 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948036 HOGENOM HOG000125881 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125881&db=HOGENOM6 IntAct P37640 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37640* InterPro IPR000792 http://www.ebi.ac.uk/interpro/entry/IPR000792 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR016032 http://www.ebi.ac.uk/interpro/entry/IPR016032 KEGG_Gene ecj:JW3488 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3488 KEGG_Gene eco:b3520 http://www.genome.jp/dbget-bin/www_bget?eco:b3520 MINT MINT-1305907 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1305907 OMA HEMMQFN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HEMMQFN PRINTS PR00038 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00038 PROSITE PS00622 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00622 PROSITE PS50043 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50043 PSORT swissprot:YHJB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHJB_ECOLI PSORT-B swissprot:YHJB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHJB_ECOLI PSORT2 swissprot:YHJB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHJB_ECOLI Pfam PF00196 http://pfam.xfam.org/family/PF00196 Phobius swissprot:YHJB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHJB_ECOLI PhylomeDB P37640 http://phylomedb.org/?seqid=P37640 ProteinModelPortal P37640 http://www.proteinmodelportal.org/query/uniprot/P37640 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417977 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417977 RefSeq WP_001167676 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001167676 SMART SM00421 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00421 SMR P37640 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37640 STRING 511145.b3520 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3520&targetmode=cogs SUPFAM SSF46894 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46894 UniProtKB YHJB_ECOLI http://www.uniprot.org/uniprot/YHJB_ECOLI UniProtKB-AC P37640 http://www.uniprot.org/uniprot/P37640 charge swissprot:YHJB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHJB_ECOLI eggNOG ENOG4106S2D http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106S2D eggNOG ENOG4111IKU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111IKU epestfind swissprot:YHJB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHJB_ECOLI garnier swissprot:YHJB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHJB_ECOLI helixturnhelix swissprot:YHJB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHJB_ECOLI hmoment swissprot:YHJB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHJB_ECOLI iep swissprot:YHJB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHJB_ECOLI inforesidue swissprot:YHJB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHJB_ECOLI octanol swissprot:YHJB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHJB_ECOLI pepcoil swissprot:YHJB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHJB_ECOLI pepdigest swissprot:YHJB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHJB_ECOLI pepinfo swissprot:YHJB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHJB_ECOLI pepnet swissprot:YHJB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHJB_ECOLI pepstats swissprot:YHJB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHJB_ECOLI pepwheel swissprot:YHJB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHJB_ECOLI pepwindow swissprot:YHJB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHJB_ECOLI sigcleave swissprot:YHJB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHJB_ECOLI ## Database ID URL or Descriptions # AltName MAA_ECOLI Maltose transacetylase # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters KM=62 mM for glucose; KM=90 mM for maltose; Vmax=0.20 mmol/min/mg enzyme with glucose as substrate; Vmax=0.11 mmol/min/mg enzyme with maltose as substrate; Note=Acetylates glucose, maltose, mannose, galactose, and fructose with a decreasing relative rate of 1, 0.55, 0.20, 0.07, 0.04.; # BRENDA 2.3.1.79 2026 # BioGrid 4261202 4 # CATALYTIC ACTIVITY MAA_ECOLI Acetyl-CoA + maltose = CoA + acetyl-maltose. # EcoGene EG14239 maa # FUNCTION MAA_ECOLI Acetylates maltose and other sugars. # GO_function GO:0008925 maltose O-acetyltransferase activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0070207 protein homotrimerization; IDA:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0006461 protein complex assembly # IntAct P77791 16 # InterPro IPR001451 Hexapep # InterPro IPR011004 Trimer_LpxA-like # InterPro IPR018357 Hexapep_transf_CS # InterPro IPR024688 Mac_dom # KEGG_Brite ko01000 Enzymes # Organism MAA_ECOLI Escherichia coli (strain K12) # PATRIC 32116071 VBIEscCol129921_0477 # PDB 1OCX X-ray; 2.15 A; A/B/C=2-183 # PIR B64776 B64776 # PROSITE PS00101 HEXAPEP_TRANSFERASES # Pfam PF12464 Mac # Pfam PF14602 Hexapep_2; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MAA_ECOLI Maltose O-acetyltransferase # RefSeq NP_414992 NC_000913.3 # RefSeq WP_000102564 NZ_LN832404.1 # SIMILARITY Belongs to the transferase hexapeptide repeat family. {ECO 0000305}. # SMART SM01266 Mac # SUBUNIT MAA_ECOLI Homodimer. # SUPFAM SSF51161 SSF51161 # eggNOG COG0110 LUCA # eggNOG ENOG4108UW5 Bacteria BLAST swissprot:MAA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MAA_ECOLI BioCyc ECOL316407:JW0448-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0448-MONOMER BioCyc EcoCyc:MALTACETYLTRAN-MONOMER http://biocyc.org/getid?id=EcoCyc:MALTACETYLTRAN-MONOMER BioCyc MetaCyc:MALTACETYLTRAN-MONOMER http://biocyc.org/getid?id=MetaCyc:MALTACETYLTRAN-MONOMER COG COG0110 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0110 DIP DIP-10140N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10140N DOI 10.1006/jmbi.1998.1726 http://dx.doi.org/10.1006/jmbi.1998.1726 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.79 http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.79 EMBL AJ223173 http://www.ebi.ac.uk/ena/data/view/AJ223173 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 ENZYME 2.3.1.79 http://enzyme.expasy.org/EC/2.3.1.79 EchoBASE EB3990 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3990 EcoGene EG14239 http://www.ecogene.org/geneInfo.php?eg_id=EG14239 EnsemblBacteria AAC73561 http://www.ensemblgenomes.org/id/AAC73561 EnsemblBacteria AAC73561 http://www.ensemblgenomes.org/id/AAC73561 EnsemblBacteria BAE76238 http://www.ensemblgenomes.org/id/BAE76238 EnsemblBacteria BAE76238 http://www.ensemblgenomes.org/id/BAE76238 EnsemblBacteria BAE76238 http://www.ensemblgenomes.org/id/BAE76238 EnsemblBacteria b0459 http://www.ensemblgenomes.org/id/b0459 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008925 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008925 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0070207 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070207 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GeneID 945096 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945096 HOGENOM HOG000049435 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000049435&db=HOGENOM6 InParanoid P77791 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77791 IntAct P77791 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77791* IntEnz 2.3.1.79 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.79 InterPro IPR001451 http://www.ebi.ac.uk/interpro/entry/IPR001451 InterPro IPR011004 http://www.ebi.ac.uk/interpro/entry/IPR011004 InterPro IPR018357 http://www.ebi.ac.uk/interpro/entry/IPR018357 InterPro IPR024688 http://www.ebi.ac.uk/interpro/entry/IPR024688 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0448 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0448 KEGG_Gene eco:b0459 http://www.genome.jp/dbget-bin/www_bget?eco:b0459 KEGG_Orthology KO:K00661 http://www.genome.jp/dbget-bin/www_bget?KO:K00661 OMA VIRPPFH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VIRPPFH PDB 1OCX http://www.ebi.ac.uk/pdbe-srv/view/entry/1OCX PDBsum 1OCX http://www.ebi.ac.uk/pdbsum/1OCX PROSITE PS00101 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00101 PSORT swissprot:MAA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MAA_ECOLI PSORT-B swissprot:MAA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MAA_ECOLI PSORT2 swissprot:MAA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MAA_ECOLI Pfam PF12464 http://pfam.xfam.org/family/PF12464 Pfam PF14602 http://pfam.xfam.org/family/PF14602 Phobius swissprot:MAA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MAA_ECOLI PhylomeDB P77791 http://phylomedb.org/?seqid=P77791 ProteinModelPortal P77791 http://www.proteinmodelportal.org/query/uniprot/P77791 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1856235 http://www.ncbi.nlm.nih.gov/pubmed/1856235 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 RefSeq NP_414992 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414992 RefSeq WP_000102564 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000102564 SMART SM01266 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01266 SMR P77791 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77791 STRING 511145.b0459 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0459&targetmode=cogs STRING COG0110 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0110&targetmode=cogs SUPFAM SSF51161 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51161 SWISS-2DPAGE P77791 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P77791 UniProtKB MAA_ECOLI http://www.uniprot.org/uniprot/MAA_ECOLI UniProtKB-AC P77791 http://www.uniprot.org/uniprot/P77791 charge swissprot:MAA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MAA_ECOLI eggNOG COG0110 http://eggnogapi.embl.de/nog_data/html/tree/COG0110 eggNOG ENOG4108UW5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UW5 epestfind swissprot:MAA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MAA_ECOLI garnier swissprot:MAA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MAA_ECOLI helixturnhelix swissprot:MAA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MAA_ECOLI hmoment swissprot:MAA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MAA_ECOLI iep swissprot:MAA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MAA_ECOLI inforesidue swissprot:MAA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MAA_ECOLI octanol swissprot:MAA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MAA_ECOLI pepcoil swissprot:MAA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MAA_ECOLI pepdigest swissprot:MAA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MAA_ECOLI pepinfo swissprot:MAA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MAA_ECOLI pepnet swissprot:MAA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MAA_ECOLI pepstats swissprot:MAA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MAA_ECOLI pepwheel swissprot:MAA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MAA_ECOLI pepwindow swissprot:MAA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MAA_ECOLI sigcleave swissprot:MAA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MAA_ECOLI ## Database ID URL or Descriptions # AltName THII_ECOLI Sulfur carrier protein ThiS sulfurtransferase # AltName THII_ECOLI Thiamine biosynthesis protein ThiI # AltName THII_ECOLI tRNA 4-thiouridine synthase # BIOPHYSICOCHEMICAL PROPERTIES THII_ECOLI Kinetic parameters KM=0.24 mM for ATP {ECO 0000269|PubMed 18604845}; KM=0.84 mM for GTP {ECO 0000269|PubMed 18604845}; Vmax=1.9 nmol/min/mg enzyme with ATP as cosubstrate {ECO 0000269|PubMed 18604845}; Vmax=1.29 nmol/min/mg enzyme with GTP as cosubstrate {ECO 0000269|PubMed 18604845}; # CATALYTIC ACTIVITY L-cysteine + 'activated' tRNA = L-serine + tRNA containing a thionucleotide. {ECO:0000269|PubMed 10753862}. # CATALYTIC ACTIVITY [IscS]-SSH + [ThiS]-COAMP = [IscS]-SH + [ThiS]-COSH + AMP. {ECO:0000269|PubMed 10753862}. # EcoGene EG13273 thiI # FUNCTION THII_ECOLI Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. {ECO 0000269|PubMed 10722656, ECO 0000269|PubMed 10753862, ECO 0000269|PubMed 18604845}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000049 tRNA binding; IDA:EcoCyc. # GO_function GO:0004810 tRNA adenylyltransferase activity; IEA:InterPro. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0016783 sulfurtransferase activity; IEA:UniProtKB-HAMAP. # GO_process GO:0002937 tRNA 4-thiouridine biosynthesis; IMP:EcoCyc. # GO_process GO:0009228 thiamine biosynthetic process; IMP:EcoCyc. # GO_process GO:0009229 thiamine diphosphate biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0052837 thiazole biosynthetic process; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.250.10 -; 1. # Gene3D 3.40.50.620 -; 1. # HAMAP MF_00021 ThiI # IntAct P77718 12 # InterPro IPR001763 Rhodanese-like_dom # InterPro IPR003720 tRNA_STrfase # InterPro IPR004114 THUMP_dom # InterPro IPR014729 Rossmann-like_a/b/a_fold # InterPro IPR020536 ThiI_AANH # InterPro IPR026340 Thiazole_biosynth_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko03016 Transfer RNA biogenesis # KEGG_Pathway ko00730 Thiamine metabolism # KEGG_Pathway ko04122 Sulfur relay system # Organism THII_ECOLI Escherichia coli (strain K12) # PATHWAY THII_ECOLI Cofactor biosynthesis; thiamine diphosphate biosynthesis. # PATRIC 32115997 VBIEscCol129921_0440 # PIR G64771 G64771 # PROSITE PS50206 RHODANESE_3 # PROSITE PS51165 THUMP # Pfam PF02568 ThiI # Pfam PF02926 THUMP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName THII_ECOLI tRNA sulfurtransferase # RefSeq NP_414957 NC_000913.3 # RefSeq WP_000668662 NZ_LN832404.1 # SIMILARITY Belongs to the ThiI family. {ECO 0000305}. # SIMILARITY Contains 1 THUMP domain. {ECO 0000305}. # SIMILARITY Contains 1 rhodanese domain. {ECO 0000305}. # SMART SM00981 THUMP # SUBCELLULAR LOCATION THII_ECOLI Cytoplasm. # SUPFAM SSF52821 SSF52821 # TIGRFAMs TIGR00342 TIGR00342 # TIGRFAMs TIGR04271 ThiI_C_thiazole # eggNOG COG0301 LUCA # eggNOG COG0607 LUCA # eggNOG ENOG4105D8I Bacteria BLAST swissprot:THII_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:THII_ECOLI BioCyc ECOL316407:JW0413-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0413-MONOMER BioCyc EcoCyc:THII-MONOMER http://biocyc.org/getid?id=EcoCyc:THII-MONOMER BioCyc MetaCyc:THII-MONOMER http://biocyc.org/getid?id=MetaCyc:THII-MONOMER COG COG0301 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0301 DIP DIP-10985N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10985N DOI 10.1002/cbic.200800033 http://dx.doi.org/10.1002/cbic.200800033 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1039/b208626c http://dx.doi.org/10.1039/b208626c DOI 10.1039/b604040c http://dx.doi.org/10.1039/b604040c DOI 10.1074/jbc.273.26.16555 http://dx.doi.org/10.1074/jbc.273.26.16555 DOI 10.1074/jbc.275.12.8283 http://dx.doi.org/10.1074/jbc.275.12.8283 DOI 10.1074/jbc.275.15.10727 http://dx.doi.org/10.1074/jbc.275.15.10727 DOI 10.1074/jbc.M104067200 http://dx.doi.org/10.1074/jbc.M104067200 DOI 10.1093/nar/26.11.2606 http://dx.doi.org/10.1093/nar/26.11.2606 DOI 10.1110/ps.8.11.2424 http://dx.doi.org/10.1110/ps.8.11.2424 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.8.1.4 http://www.genome.jp/dbget-bin/www_bget?EC:2.8.1.4 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U34923 http://www.ebi.ac.uk/ena/data/view/U34923 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 ENZYME 2.8.1.4 http://enzyme.expasy.org/EC/2.8.1.4 EchoBASE EB3058 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3058 EcoGene EG13273 http://www.ecogene.org/geneInfo.php?eg_id=EG13273 EnsemblBacteria AAC73526 http://www.ensemblgenomes.org/id/AAC73526 EnsemblBacteria AAC73526 http://www.ensemblgenomes.org/id/AAC73526 EnsemblBacteria BAE76203 http://www.ensemblgenomes.org/id/BAE76203 EnsemblBacteria BAE76203 http://www.ensemblgenomes.org/id/BAE76203 EnsemblBacteria BAE76203 http://www.ensemblgenomes.org/id/BAE76203 EnsemblBacteria b0423 http://www.ensemblgenomes.org/id/b0423 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000049 GO_function GO:0004810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004810 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016783 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016783 GO_process GO:0002937 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002937 GO_process GO:0009228 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009228 GO_process GO:0009229 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009229 GO_process GO:0052837 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052837 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.250.10 http://www.cathdb.info/version/latest/superfamily/3.40.250.10 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 GeneID 945067 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945067 HAMAP MF_00021 http://hamap.expasy.org/unirule/MF_00021 HOGENOM HOG000227469 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000227469&db=HOGENOM6 InParanoid P77718 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77718 IntAct P77718 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77718* IntEnz 2.8.1.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.8.1.4 InterPro IPR001763 http://www.ebi.ac.uk/interpro/entry/IPR001763 InterPro IPR003720 http://www.ebi.ac.uk/interpro/entry/IPR003720 InterPro IPR004114 http://www.ebi.ac.uk/interpro/entry/IPR004114 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 InterPro IPR020536 http://www.ebi.ac.uk/interpro/entry/IPR020536 InterPro IPR026340 http://www.ebi.ac.uk/interpro/entry/IPR026340 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW0413 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0413 KEGG_Gene eco:b0423 http://www.genome.jp/dbget-bin/www_bget?eco:b0423 KEGG_Orthology KO:K03151 http://www.genome.jp/dbget-bin/www_bget?KO:K03151 KEGG_Pathway ko00730 http://www.genome.jp/kegg-bin/show_pathway?ko00730 KEGG_Pathway ko04122 http://www.genome.jp/kegg-bin/show_pathway?ko04122 KEGG_Reaction rn:R07461 http://www.genome.jp/dbget-bin/www_bget?rn:R07461 OMA KLFPEIM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KLFPEIM PROSITE PS50206 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50206 PROSITE PS51165 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51165 PSORT swissprot:THII_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:THII_ECOLI PSORT-B swissprot:THII_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:THII_ECOLI PSORT2 swissprot:THII_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:THII_ECOLI Pfam PF02568 http://pfam.xfam.org/family/PF02568 Pfam PF02926 http://pfam.xfam.org/family/PF02926 Phobius swissprot:THII_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:THII_ECOLI PhylomeDB P77718 http://phylomedb.org/?seqid=P77718 ProteinModelPortal P77718 http://www.proteinmodelportal.org/query/uniprot/P77718 PubMed 10595545 http://www.ncbi.nlm.nih.gov/pubmed/10595545 PubMed 10722656 http://www.ncbi.nlm.nih.gov/pubmed/10722656 PubMed 10753862 http://www.ncbi.nlm.nih.gov/pubmed/10753862 PubMed 11443125 http://www.ncbi.nlm.nih.gov/pubmed/11443125 PubMed 12510310 http://www.ncbi.nlm.nih.gov/pubmed/12510310 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16855700 http://www.ncbi.nlm.nih.gov/pubmed/16855700 PubMed 18604845 http://www.ncbi.nlm.nih.gov/pubmed/18604845 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9592144 http://www.ncbi.nlm.nih.gov/pubmed/9592144 PubMed 9632726 http://www.ncbi.nlm.nih.gov/pubmed/9632726 RefSeq NP_414957 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414957 RefSeq WP_000668662 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000668662 SMART SM00981 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00981 SMR P77718 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77718 STRING 511145.b0423 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0423&targetmode=cogs STRING COG0301 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0301&targetmode=cogs SUPFAM SSF52821 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52821 TIGRFAMs TIGR00342 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00342 TIGRFAMs TIGR04271 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR04271 UniProtKB THII_ECOLI http://www.uniprot.org/uniprot/THII_ECOLI UniProtKB-AC P77718 http://www.uniprot.org/uniprot/P77718 charge swissprot:THII_ECOLI http://rest.g-language.org/emboss/charge/swissprot:THII_ECOLI eggNOG COG0301 http://eggnogapi.embl.de/nog_data/html/tree/COG0301 eggNOG COG0607 http://eggnogapi.embl.de/nog_data/html/tree/COG0607 eggNOG ENOG4105D8I http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D8I epestfind swissprot:THII_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:THII_ECOLI garnier swissprot:THII_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:THII_ECOLI helixturnhelix swissprot:THII_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:THII_ECOLI hmoment swissprot:THII_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:THII_ECOLI iep swissprot:THII_ECOLI http://rest.g-language.org/emboss/iep/swissprot:THII_ECOLI inforesidue swissprot:THII_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:THII_ECOLI octanol swissprot:THII_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:THII_ECOLI pepcoil swissprot:THII_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:THII_ECOLI pepdigest swissprot:THII_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:THII_ECOLI pepinfo swissprot:THII_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:THII_ECOLI pepnet swissprot:THII_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:THII_ECOLI pepstats swissprot:THII_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:THII_ECOLI pepwheel swissprot:THII_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:THII_ECOLI pepwindow swissprot:THII_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:THII_ECOLI sigcleave swissprot:THII_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:THII_ECOLI ## Database ID URL or Descriptions # BioGrid 4259454 165 # CDD cd06174 MFS # EcoGene EG13973 ydiN # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0015292 uniporter activity; ISS:EcoCyc. # GO_function GO:0022891 substrate-specific transmembrane transporter activity; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # Organism YDIN_ECOLI Escherichia coli (strain K12) # PATRIC 32118688 VBIEscCol129921_1762 # PIR C64927 C64927 # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDIN_ECOLI Inner membrane transport protein YdiN # RefSeq NP_416206 NC_000913.3 # RefSeq WP_000081197 NZ_LN832404.1 # SIMILARITY Belongs to the major facilitator superfamily. {ECO 0000305}. # SUBCELLULAR LOCATION YDIN_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.15.13 the major facilitator superfamily (mfs) # eggNOG ENOG4105EMV Bacteria # eggNOG ENOG410XRAD LUCA BLAST swissprot:YDIN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDIN_ECOLI BioCyc ECOL316407:JW5274-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5274-MONOMER BioCyc EcoCyc:B1691-MONOMER http://biocyc.org/getid?id=EcoCyc:B1691-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3730 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3730 EcoGene EG13973 http://www.ecogene.org/geneInfo.php?eg_id=EG13973 EnsemblBacteria AAC74761 http://www.ensemblgenomes.org/id/AAC74761 EnsemblBacteria AAC74761 http://www.ensemblgenomes.org/id/AAC74761 EnsemblBacteria BAE76504 http://www.ensemblgenomes.org/id/BAE76504 EnsemblBacteria BAE76504 http://www.ensemblgenomes.org/id/BAE76504 EnsemblBacteria BAE76504 http://www.ensemblgenomes.org/id/BAE76504 EnsemblBacteria b1691 http://www.ensemblgenomes.org/id/b1691 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015292 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015292 GO_function GO:0022891 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022891 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GeneID 946198 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946198 HOGENOM HOG000062520 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000062520&db=HOGENOM6 InParanoid P76198 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76198 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Gene ecj:JW5274 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5274 KEGG_Gene eco:b1691 http://www.genome.jp/dbget-bin/www_bget?eco:b1691 PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:YDIN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDIN_ECOLI PSORT-B swissprot:YDIN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDIN_ECOLI PSORT2 swissprot:YDIN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDIN_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:YDIN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDIN_ECOLI PhylomeDB P76198 http://phylomedb.org/?seqid=P76198 ProteinModelPortal P76198 http://www.proteinmodelportal.org/query/uniprot/P76198 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416206 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416206 RefSeq WP_000081197 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000081197 STRING 511145.b1691 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1691&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.15.13 http://www.tcdb.org/search/result.php?tc=2.A.1.15.13 UniProtKB YDIN_ECOLI http://www.uniprot.org/uniprot/YDIN_ECOLI UniProtKB-AC P76198 http://www.uniprot.org/uniprot/P76198 charge swissprot:YDIN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDIN_ECOLI eggNOG ENOG4105EMV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EMV eggNOG ENOG410XRAD http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRAD epestfind swissprot:YDIN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDIN_ECOLI garnier swissprot:YDIN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDIN_ECOLI helixturnhelix swissprot:YDIN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDIN_ECOLI hmoment swissprot:YDIN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDIN_ECOLI iep swissprot:YDIN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDIN_ECOLI inforesidue swissprot:YDIN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDIN_ECOLI octanol swissprot:YDIN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDIN_ECOLI pepcoil swissprot:YDIN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDIN_ECOLI pepdigest swissprot:YDIN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDIN_ECOLI pepinfo swissprot:YDIN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDIN_ECOLI pepnet swissprot:YDIN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDIN_ECOLI pepstats swissprot:YDIN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDIN_ECOLI pepwheel swissprot:YDIN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDIN_ECOLI pepwindow swissprot:YDIN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDIN_ECOLI sigcleave swissprot:YDIN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDIN_ECOLI ## Database ID URL or Descriptions # BioGrid 4260753 13 # EcoGene EG14167 yfeZ # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # IntAct P76538 4 # InterPro IPR021318 DUF2919 # Organism YFEZ_ECOLI Escherichia coli (strain K12) # PATRIC 32120251 VBIEscCol129921_2528 # PIR H65017 H65017 # Pfam PF11143 DUF2919 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFEZ_ECOLI Inner membrane protein YfeZ # RefSeq NP_416928 NC_000913.3 # RefSeq WP_001350539 NZ_LN832404.1 # SUBCELLULAR LOCATION YFEZ_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 9.B.127.1 the duf2919 (pf11143) family # eggNOG ENOG4105QZU Bacteria # eggNOG ENOG4111WT6 LUCA BLAST swissprot:YFEZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFEZ_ECOLI BioCyc ECOL316407:JW2426-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2426-MONOMER BioCyc EcoCyc:G7268-MONOMER http://biocyc.org/getid?id=EcoCyc:G7268-MONOMER DIP DIP-12023N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12023N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3919 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3919 EcoGene EG14167 http://www.ecogene.org/geneInfo.php?eg_id=EG14167 EnsemblBacteria AAC75486 http://www.ensemblgenomes.org/id/AAC75486 EnsemblBacteria AAC75486 http://www.ensemblgenomes.org/id/AAC75486 EnsemblBacteria BAE76713 http://www.ensemblgenomes.org/id/BAE76713 EnsemblBacteria BAE76713 http://www.ensemblgenomes.org/id/BAE76713 EnsemblBacteria BAE76713 http://www.ensemblgenomes.org/id/BAE76713 EnsemblBacteria b2433 http://www.ensemblgenomes.org/id/b2433 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 946918 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946918 HOGENOM HOG000276862 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276862&db=HOGENOM6 IntAct P76538 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76538* InterPro IPR021318 http://www.ebi.ac.uk/interpro/entry/IPR021318 KEGG_Gene ecj:JW2426 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2426 KEGG_Gene eco:b2433 http://www.genome.jp/dbget-bin/www_bget?eco:b2433 OMA ARAWILF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ARAWILF PSORT swissprot:YFEZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFEZ_ECOLI PSORT-B swissprot:YFEZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFEZ_ECOLI PSORT2 swissprot:YFEZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFEZ_ECOLI Pfam PF11143 http://pfam.xfam.org/family/PF11143 Phobius swissprot:YFEZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFEZ_ECOLI ProteinModelPortal P76538 http://www.proteinmodelportal.org/query/uniprot/P76538 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416928 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416928 RefSeq WP_001350539 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001350539 SMR P76538 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76538 STRING 511145.b2433 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2433&targetmode=cogs TCDB 9.B.127.1 http://www.tcdb.org/search/result.php?tc=9.B.127.1 UniProtKB YFEZ_ECOLI http://www.uniprot.org/uniprot/YFEZ_ECOLI UniProtKB-AC P76538 http://www.uniprot.org/uniprot/P76538 charge swissprot:YFEZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFEZ_ECOLI eggNOG ENOG4105QZU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105QZU eggNOG ENOG4111WT6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111WT6 epestfind swissprot:YFEZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFEZ_ECOLI garnier swissprot:YFEZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFEZ_ECOLI helixturnhelix swissprot:YFEZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFEZ_ECOLI hmoment swissprot:YFEZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFEZ_ECOLI iep swissprot:YFEZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFEZ_ECOLI inforesidue swissprot:YFEZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFEZ_ECOLI octanol swissprot:YFEZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFEZ_ECOLI pepcoil swissprot:YFEZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFEZ_ECOLI pepdigest swissprot:YFEZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFEZ_ECOLI pepinfo swissprot:YFEZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFEZ_ECOLI pepnet swissprot:YFEZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFEZ_ECOLI pepstats swissprot:YFEZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFEZ_ECOLI pepwheel swissprot:YFEZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFEZ_ECOLI pepwindow swissprot:YFEZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFEZ_ECOLI sigcleave swissprot:YFEZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFEZ_ECOLI ## Database ID URL or Descriptions # BioGrid 4260343 143 # EcoGene EG13515 yoaC # InterPro IPR015079 DUF1889 # Organism YOAC_ECOLI Escherichia coli (strain K12) # PATRIC 32118939 VBIEscCol129921_1887 # PIR B64942 B64942 # Pfam PF08986 DUF1889 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YOAC_ECOLI Uncharacterized protein YoaC # RefSeq NP_416324 NC_000913.3 # RefSeq WP_001111995 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAE76534.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # eggNOG ENOG4105V2F Bacteria # eggNOG ENOG4111Z3C LUCA BLAST swissprot:YOAC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YOAC_ECOLI BioCyc ECOL316407:JW5296-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5296-MONOMER BioCyc EcoCyc:G6994-MONOMER http://biocyc.org/getid?id=EcoCyc:G6994-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3288 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3288 EcoGene EG13515 http://www.ecogene.org/geneInfo.php?eg_id=EG13515 EnsemblBacteria AAC74880 http://www.ensemblgenomes.org/id/AAC74880 EnsemblBacteria AAC74880 http://www.ensemblgenomes.org/id/AAC74880 EnsemblBacteria BAE76534 http://www.ensemblgenomes.org/id/BAE76534 EnsemblBacteria BAE76534 http://www.ensemblgenomes.org/id/BAE76534 EnsemblBacteria BAE76534 http://www.ensemblgenomes.org/id/BAE76534 EnsemblBacteria b1810 http://www.ensemblgenomes.org/id/b1810 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946308 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946308 HOGENOM HOG000121164 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000121164&db=HOGENOM6 InterPro IPR015079 http://www.ebi.ac.uk/interpro/entry/IPR015079 KEGG_Gene ecj:JW5296 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5296 KEGG_Gene eco:b1810 http://www.genome.jp/dbget-bin/www_bget?eco:b1810 PSORT swissprot:YOAC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YOAC_ECOLI PSORT-B swissprot:YOAC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YOAC_ECOLI PSORT2 swissprot:YOAC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YOAC_ECOLI Pfam PF08986 http://pfam.xfam.org/family/PF08986 Phobius swissprot:YOAC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YOAC_ECOLI ProteinModelPortal P64490 http://www.proteinmodelportal.org/query/uniprot/P64490 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416324 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416324 RefSeq WP_001111995 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001111995 SMR P64490 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P64490 STRING 511145.b1810 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1810&targetmode=cogs UniProtKB YOAC_ECOLI http://www.uniprot.org/uniprot/YOAC_ECOLI UniProtKB-AC P64490 http://www.uniprot.org/uniprot/P64490 charge swissprot:YOAC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YOAC_ECOLI eggNOG ENOG4105V2F http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105V2F eggNOG ENOG4111Z3C http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111Z3C epestfind swissprot:YOAC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YOAC_ECOLI garnier swissprot:YOAC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YOAC_ECOLI helixturnhelix swissprot:YOAC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YOAC_ECOLI hmoment swissprot:YOAC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YOAC_ECOLI iep swissprot:YOAC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YOAC_ECOLI inforesidue swissprot:YOAC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YOAC_ECOLI octanol swissprot:YOAC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YOAC_ECOLI pepcoil swissprot:YOAC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YOAC_ECOLI pepdigest swissprot:YOAC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YOAC_ECOLI pepinfo swissprot:YOAC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YOAC_ECOLI pepnet swissprot:YOAC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YOAC_ECOLI pepstats swissprot:YOAC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YOAC_ECOLI pepwheel swissprot:YOAC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YOAC_ECOLI pepwindow swissprot:YOAC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YOAC_ECOLI sigcleave swissprot:YOAC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YOAC_ECOLI ## Database ID URL or Descriptions # AltName DSBE_ECOLI Cytochrome c biogenesis protein CcmG # BioGrid 4263405 11 # CDD cd03010 TlpA_like_DsbE # EcoGene EG12053 dsbE # FUNCTION DSBE_ECOLI Involved in disulfide bond formation. Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme lyase. DsbE is maintained in a reduced state by DsbD. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IEA:InterPro. # GO_component GO:0031237 intrinsic component of periplasmic side of plasma membrane; IDA:EcoCyc. # GO_function GO:0015036 disulfide oxidoreductase activity; IDA:EcoCyc. # GO_process GO:0017004 cytochrome complex assembly; IMP:EcoCyc. # GO_process GO:0045454 cell redox homeostasis; IEA:InterPro. # GO_process GO:0055114 oxidation-reduction process; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0008150 biological_process # GOslim_process GO:0042592 homeostatic process # Gene3D 3.40.30.10 -; 1. # InterPro IPR004799 Periplasmic_diS_OxRdtase_DsbE # InterPro IPR012336 Thioredoxin-like_fold # InterPro IPR013740 Redoxin # InterPro IPR013766 Thioredoxin_domain # InterPro IPR017937 Thioredoxin_CS # KEGG_Brite ko03110 Chaperones and folding catalysts # Organism DSBE_ECOLI Escherichia coli (strain K12) # PATRIC 32119749 VBIEscCol129921_2284 # PDB 1Z5Y X-ray; 1.94 A; E=43-185 # PDB 2B1K X-ray; 1.90 A; A=19-185 # PDB 2B1L X-ray; 1.90 A; A/B=58-185 # PDB 2G0F X-ray; 2.20 A; A=19-185 # PDB 3K8N X-ray; 2.30 A; A=1-185 # PIR A64989 A64989 # PROSITE PS00194 THIOREDOXIN_1 # PROSITE PS51352 THIOREDOXIN_2 # Pfam PF08534 Redoxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Thiol disulfide interchange protein DsbE # RefSeq NP_416699 NC_000913.3 # RefSeq WP_000824439 NZ_LN832404.1 # SIMILARITY Belongs to the thioredoxin family. DsbE subfamily. {ECO 0000305}. # SIMILARITY Contains 1 thioredoxin domain. {ECO:0000255|PROSITE- ProRule PRU00691}. # SUBCELLULAR LOCATION DSBE_ECOLI Cell inner membrane; Single-pass membrane protein; Periplasmic side. # SUPFAM SSF52833 SSF52833 # TIGRFAMs TIGR00385 dsbE # eggNOG COG0526 LUCA # eggNOG ENOG4107QX9 Bacteria BLAST swissprot:DSBE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DSBE_ECOLI BioCyc ECOL316407:JW2183-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2183-MONOMER BioCyc EcoCyc:EG12053-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12053-MONOMER COG COG0526 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0526 DIP DIP-48446N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48446N DOI 10.1006/bbrc.2001.4876 http://dx.doi.org/10.1006/bbrc.2001.4876 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/0264-6021:3550051 http://dx.doi.org/10.1042/0264-6021:3550051 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1515/BC.2001.203 http://dx.doi.org/10.1515/BC.2001.203 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00008 http://www.ebi.ac.uk/ena/data/view/U00008 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1984 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1984 EcoGene EG12053 http://www.ecogene.org/geneInfo.php?eg_id=EG12053 EnsemblBacteria AAC75255 http://www.ensemblgenomes.org/id/AAC75255 EnsemblBacteria AAC75255 http://www.ensemblgenomes.org/id/AAC75255 EnsemblBacteria BAE76658 http://www.ensemblgenomes.org/id/BAE76658 EnsemblBacteria BAE76658 http://www.ensemblgenomes.org/id/BAE76658 EnsemblBacteria BAE76658 http://www.ensemblgenomes.org/id/BAE76658 EnsemblBacteria b2195 http://www.ensemblgenomes.org/id/b2195 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_component GO:0031237 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031237 GO_function GO:0015036 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015036 GO_process GO:0017004 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017004 GO_process GO:0045454 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045454 GO_process GO:0055114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 Gene3D 3.40.30.10 http://www.cathdb.info/version/latest/superfamily/3.40.30.10 GeneID 949073 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949073 HOGENOM HOG000097218 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000097218&db=HOGENOM6 InParanoid P0AA86 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AA86 InterPro IPR004799 http://www.ebi.ac.uk/interpro/entry/IPR004799 InterPro IPR012336 http://www.ebi.ac.uk/interpro/entry/IPR012336 InterPro IPR013740 http://www.ebi.ac.uk/interpro/entry/IPR013740 InterPro IPR013766 http://www.ebi.ac.uk/interpro/entry/IPR013766 InterPro IPR017937 http://www.ebi.ac.uk/interpro/entry/IPR017937 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW2183 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2183 KEGG_Gene eco:b2195 http://www.genome.jp/dbget-bin/www_bget?eco:b2195 KEGG_Orthology KO:K02199 http://www.genome.jp/dbget-bin/www_bget?KO:K02199 OMA KWLAEFH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KWLAEFH PDB 1Z5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/1Z5Y PDB 2B1K http://www.ebi.ac.uk/pdbe-srv/view/entry/2B1K PDB 2B1L http://www.ebi.ac.uk/pdbe-srv/view/entry/2B1L PDB 2G0F http://www.ebi.ac.uk/pdbe-srv/view/entry/2G0F PDB 3K8N http://www.ebi.ac.uk/pdbe-srv/view/entry/3K8N PDBsum 1Z5Y http://www.ebi.ac.uk/pdbsum/1Z5Y PDBsum 2B1K http://www.ebi.ac.uk/pdbsum/2B1K PDBsum 2B1L http://www.ebi.ac.uk/pdbsum/2B1L PDBsum 2G0F http://www.ebi.ac.uk/pdbsum/2G0F PDBsum 3K8N http://www.ebi.ac.uk/pdbsum/3K8N PROSITE PS00194 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00194 PROSITE PS51352 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51352 PSORT swissprot:DSBE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DSBE_ECOLI PSORT-B swissprot:DSBE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DSBE_ECOLI PSORT2 swissprot:DSBE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DSBE_ECOLI Pfam PF08534 http://pfam.xfam.org/family/PF08534 Phobius swissprot:DSBE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DSBE_ECOLI PhylomeDB P0AA86 http://phylomedb.org/?seqid=P0AA86 ProteinModelPortal P0AA86 http://www.proteinmodelportal.org/query/uniprot/P0AA86 PubMed 11256948 http://www.ncbi.nlm.nih.gov/pubmed/11256948 PubMed 11350062 http://www.ncbi.nlm.nih.gov/pubmed/11350062 PubMed 11843181 http://www.ncbi.nlm.nih.gov/pubmed/11843181 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7635817 http://www.ncbi.nlm.nih.gov/pubmed/7635817 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9537397 http://www.ncbi.nlm.nih.gov/pubmed/9537397 RefSeq NP_416699 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416699 RefSeq WP_000824439 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000824439 SMR P0AA86 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AA86 STRING 511145.b2195 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2195&targetmode=cogs STRING COG0526 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0526&targetmode=cogs SUPFAM SSF52833 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52833 TIGRFAMs TIGR00385 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00385 UniProtKB DSBE_ECOLI http://www.uniprot.org/uniprot/DSBE_ECOLI UniProtKB-AC P0AA86 http://www.uniprot.org/uniprot/P0AA86 charge swissprot:DSBE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DSBE_ECOLI eggNOG COG0526 http://eggnogapi.embl.de/nog_data/html/tree/COG0526 eggNOG ENOG4107QX9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QX9 epestfind swissprot:DSBE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DSBE_ECOLI garnier swissprot:DSBE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DSBE_ECOLI helixturnhelix swissprot:DSBE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DSBE_ECOLI hmoment swissprot:DSBE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DSBE_ECOLI iep swissprot:DSBE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DSBE_ECOLI inforesidue swissprot:DSBE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DSBE_ECOLI octanol swissprot:DSBE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DSBE_ECOLI pepcoil swissprot:DSBE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DSBE_ECOLI pepdigest swissprot:DSBE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DSBE_ECOLI pepinfo swissprot:DSBE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DSBE_ECOLI pepnet swissprot:DSBE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DSBE_ECOLI pepstats swissprot:DSBE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DSBE_ECOLI pepwheel swissprot:DSBE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DSBE_ECOLI pepwindow swissprot:DSBE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DSBE_ECOLI sigcleave swissprot:DSBE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DSBE_ECOLI ## Database ID URL or Descriptions # BioGrid 4261340 190 # CATALYTIC ACTIVITY WECG_ECOLI UDP-N-acetyl-alpha-D-mannosaminouronate + N- acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = UDP + N-acetyl-beta-D-mannosaminouronyl-(1->4)-N-acetyl-alpha-D- glucosaminyl-diphospho-ditrans,octacis-undecaprenol. {ECO 0000255|HAMAP-Rule MF_01001, ECO 0000269|PubMed 3275612}. # CAZy GT26 Glycosyltransferase Family 26 # CDD cd06533 Glyco_transf_WecG_TagA # EcoGene EG11458 rffM # FUNCTION WECG_ECOLI Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis. {ECO 0000255|HAMAP-Rule MF_01001, ECO 0000269|PubMed 1730666}. # GO_function GO:0016758 transferase activity, transferring hexosyl groups; IMP:EcoCyc. # GO_function GO:0047241 lipopolysaccharide N-acetylmannosaminouronosyltransferase activity; IEA:UniProtKB-HAMAP. # GO_process GO:0009246 enterobacterial common antigen biosynthetic process; IMP:EcoCyc. # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # HAMAP MF_01001 WecG_RffM # IntAct P27836 15 # InterPro IPR004629 WecB_TagA_CpsF # InterPro IPR023085 UDP-ManNAcA_Trfase_WecG # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01003 Glycosyltransferases # Organism WECG_ECOLI Escherichia coli (strain K12) # PATHWAY Bacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis. {ECO:0000255|HAMAP-Rule MF_01001}. # PATRIC 32123083 VBIEscCol129921_3911 # PIR G65183 G65183 # Pfam PF03808 Glyco_tran_WecB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UDP-N-acetyl-D-mannosaminuronic acid transferase {ECO:0000255|HAMAP-Rule MF_01001} # RefSeq NP_418242 NC_000913.3 # RefSeq WP_001064040 NZ_LN832404.1 # SIMILARITY Belongs to the glycosyltransferase 26 family. {ECO:0000255|HAMAP-Rule MF_01001}. # TIGRFAMs TIGR00696 wecG_tagA_cpsF # eggNOG COG1922 LUCA # eggNOG ENOG4108UHC Bacteria BLAST swissprot:WECG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:WECG_ECOLI BioCyc ECOL316407:JW3770-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3770-MONOMER BioCyc EcoCyc:UDPMANACATRANS-MONOMER http://biocyc.org/getid?id=EcoCyc:UDPMANACATRANS-MONOMER BioCyc MetaCyc:UDPMANACATRANS-MONOMER http://biocyc.org/getid?id=MetaCyc:UDPMANACATRANS-MONOMER COG CAZy: http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=CAZy: COG COG1922 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1922 COG GT26 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=GT26 DIP DIP-11132N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11132N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.4.1.180 {ECO:0000255|HAMAP-Rule:MF_01001} http://www.genome.jp/dbget-bin/www_bget?EC:2.4.1.180 {ECO:0000255|HAMAP-Rule:MF_01001} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.4.1.180 {ECO:0000255|HAMAP-Rule:MF_01001} http://enzyme.expasy.org/EC/2.4.1.180 {ECO:0000255|HAMAP-Rule:MF_01001} EchoBASE EB1427 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1427 EcoGene EG11458 http://www.ecogene.org/geneInfo.php?eg_id=EG11458 EnsemblBacteria AAC76801 http://www.ensemblgenomes.org/id/AAC76801 EnsemblBacteria AAC76801 http://www.ensemblgenomes.org/id/AAC76801 EnsemblBacteria BAE77503 http://www.ensemblgenomes.org/id/BAE77503 EnsemblBacteria BAE77503 http://www.ensemblgenomes.org/id/BAE77503 EnsemblBacteria BAE77503 http://www.ensemblgenomes.org/id/BAE77503 EnsemblBacteria b3794 http://www.ensemblgenomes.org/id/b3794 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016758 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016758 GO_function GO:0047241 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047241 GO_process GO:0009246 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009246 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 948301 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948301 HAMAP MF_01001 http://hamap.expasy.org/unirule/MF_01001 HOGENOM HOG000075380 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000075380&db=HOGENOM6 InParanoid P27836 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P27836 IntAct P27836 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P27836* IntEnz 2.4.1.180 {ECO:0000255|HAMAP-Rule:MF_01001} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.1.180 {ECO:0000255|HAMAP-Rule:MF_01001} InterPro IPR004629 http://www.ebi.ac.uk/interpro/entry/IPR004629 InterPro IPR023085 http://www.ebi.ac.uk/interpro/entry/IPR023085 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01003 http://www.genome.jp/dbget-bin/www_bget?ko01003 KEGG_Gene ecj:JW3770 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3770 KEGG_Gene eco:b3794 http://www.genome.jp/dbget-bin/www_bget?eco:b3794 KEGG_Orthology KO:K02852 http://www.genome.jp/dbget-bin/www_bget?KO:K02852 MINT MINT-1229961 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1229961 OMA ATPNAEI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ATPNAEI PSORT swissprot:WECG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:WECG_ECOLI PSORT-B swissprot:WECG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:WECG_ECOLI PSORT2 swissprot:WECG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:WECG_ECOLI Pfam PF03808 http://pfam.xfam.org/family/PF03808 Phobius swissprot:WECG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:WECG_ECOLI PhylomeDB P27836 http://phylomedb.org/?seqid=P27836 ProteinModelPortal P27836 http://www.proteinmodelportal.org/query/uniprot/P27836 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1730666 http://www.ncbi.nlm.nih.gov/pubmed/1730666 PubMed 3275612 http://www.ncbi.nlm.nih.gov/pubmed/3275612 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418242 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418242 RefSeq WP_001064040 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001064040 SMR P27836 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P27836 STRING 511145.b3794 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3794&targetmode=cogs STRING CAZy: http://string-db.org/newstring_cgi/show_network_section.pl?identifier=CAZy:&targetmode=cogs STRING COG1922 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1922&targetmode=cogs STRING GT26 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=GT26&targetmode=cogs TIGRFAMs TIGR00696 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00696 UniProtKB WECG_ECOLI http://www.uniprot.org/uniprot/WECG_ECOLI UniProtKB-AC P27836 http://www.uniprot.org/uniprot/P27836 charge swissprot:WECG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:WECG_ECOLI eggNOG COG1922 http://eggnogapi.embl.de/nog_data/html/tree/COG1922 eggNOG ENOG4108UHC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UHC epestfind swissprot:WECG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:WECG_ECOLI garnier swissprot:WECG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:WECG_ECOLI helixturnhelix swissprot:WECG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:WECG_ECOLI hmoment swissprot:WECG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:WECG_ECOLI iep swissprot:WECG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:WECG_ECOLI inforesidue swissprot:WECG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:WECG_ECOLI octanol swissprot:WECG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:WECG_ECOLI pepcoil swissprot:WECG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:WECG_ECOLI pepdigest swissprot:WECG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:WECG_ECOLI pepinfo swissprot:WECG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:WECG_ECOLI pepnet swissprot:WECG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:WECG_ECOLI pepstats swissprot:WECG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:WECG_ECOLI pepwheel swissprot:WECG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:WECG_ECOLI pepwindow swissprot:WECG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:WECG_ECOLI sigcleave swissprot:WECG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:WECG_ECOLI ## Database ID URL or Descriptions # AltName PTFC1_ECOLI PTS system fructose-like EIIC component 1 # BioGrid 4260562 9 # DOMAIN PTFC1_ECOLI The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site. # EcoGene EG14154 fryC # FUNCTION PTFC1_ECOLI The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. {ECO 0000250}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0008982 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:InterPro. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; ISA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR003352 PTS_EIIC # InterPro IPR013014 PTS_EIIC_2 # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00306 PTS system, fructose-specific II-like component # KEGG_Brite ko02000 Transporters # Organism PTFC1_ECOLI Escherichia coli (strain K12) # PATRIC 32120151 VBIEscCol129921_2484 # PIR G65012 G65012 # PROSITE PS51104 PTS_EIIC_TYPE_2 # Pfam PF02378 PTS_EIIC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PTFC1_ECOLI Fructose-like permease IIC component 1 # RefSeq NP_416887 NC_000913.3 # RefSeq WP_000985359 NZ_LN832404.1 # SIMILARITY Contains 1 PTS EIIC type-2 domain. {ECO:0000255|PROSITE-ProRule PRU00427}. # SUBCELLULAR LOCATION PTFC1_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 4.A.2.1.11 the pts fructose-mannitol (fru) family # eggNOG COG1299 LUCA # eggNOG ENOG410863U Bacteria BLAST swissprot:PTFC1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTFC1_ECOLI BioCyc ECOL316407:JW2383-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2383-MONOMER BioCyc EcoCyc:MONOMER0-6 http://biocyc.org/getid?id=EcoCyc:MONOMER0-6 COG COG1299 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1299 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3906 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3906 EcoGene EG14154 http://www.ecogene.org/geneInfo.php?eg_id=EG14154 EnsemblBacteria AAC75445 http://www.ensemblgenomes.org/id/AAC75445 EnsemblBacteria AAC75445 http://www.ensemblgenomes.org/id/AAC75445 EnsemblBacteria BAA16256 http://www.ensemblgenomes.org/id/BAA16256 EnsemblBacteria BAA16256 http://www.ensemblgenomes.org/id/BAA16256 EnsemblBacteria BAA16256 http://www.ensemblgenomes.org/id/BAA16256 EnsemblBacteria b2386 http://www.ensemblgenomes.org/id/b2386 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008982 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008982 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 949111 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949111 HOGENOM HOG000122934 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122934&db=HOGENOM6 InterPro IPR003352 http://www.ebi.ac.uk/interpro/entry/IPR003352 InterPro IPR013014 http://www.ebi.ac.uk/interpro/entry/IPR013014 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2383 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2383 KEGG_Gene eco:b2386 http://www.genome.jp/dbget-bin/www_bget?eco:b2386 KEGG_Orthology KO:K11203 http://www.genome.jp/dbget-bin/www_bget?KO:K11203 OMA WAWPLVS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WAWPLVS PROSITE PS51104 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51104 PSORT swissprot:PTFC1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTFC1_ECOLI PSORT-B swissprot:PTFC1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTFC1_ECOLI PSORT2 swissprot:PTFC1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTFC1_ECOLI Pfam PF02378 http://pfam.xfam.org/family/PF02378 Phobius swissprot:PTFC1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTFC1_ECOLI PhylomeDB P77579 http://phylomedb.org/?seqid=P77579 ProteinModelPortal P77579 http://www.proteinmodelportal.org/query/uniprot/P77579 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416887 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416887 RefSeq WP_000985359 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000985359 STRING 511145.b2386 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2386&targetmode=cogs STRING COG1299 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1299&targetmode=cogs TCDB 4.A.2.1.11 http://www.tcdb.org/search/result.php?tc=4.A.2.1.11 UniProtKB PTFC1_ECOLI http://www.uniprot.org/uniprot/PTFC1_ECOLI UniProtKB-AC P77579 http://www.uniprot.org/uniprot/P77579 charge swissprot:PTFC1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTFC1_ECOLI eggNOG COG1299 http://eggnogapi.embl.de/nog_data/html/tree/COG1299 eggNOG ENOG410863U http://eggnogapi.embl.de/nog_data/html/tree/ENOG410863U epestfind swissprot:PTFC1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTFC1_ECOLI garnier swissprot:PTFC1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTFC1_ECOLI helixturnhelix swissprot:PTFC1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTFC1_ECOLI hmoment swissprot:PTFC1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTFC1_ECOLI iep swissprot:PTFC1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTFC1_ECOLI inforesidue swissprot:PTFC1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTFC1_ECOLI octanol swissprot:PTFC1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTFC1_ECOLI pepcoil swissprot:PTFC1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTFC1_ECOLI pepdigest swissprot:PTFC1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTFC1_ECOLI pepinfo swissprot:PTFC1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTFC1_ECOLI pepnet swissprot:PTFC1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTFC1_ECOLI pepstats swissprot:PTFC1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTFC1_ECOLI pepwheel swissprot:PTFC1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTFC1_ECOLI pepwindow swissprot:PTFC1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTFC1_ECOLI sigcleave swissprot:PTFC1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTFC1_ECOLI ## Database ID URL or Descriptions # BioGrid 4263107 9 # EcoGene EG13828 rzpQ # InterPro IPR019659 DUF2514 # MISCELLANEOUS RZPQ_ECOLI A putative lipoprotein (RzoQ, AC C1P601) is entirely encoded within this gene, on the same strand within another reading frame. # Organism RZPQ_ECOLI Escherichia coli (strain K12) # PATRIC 32118408 VBIEscCol129921_1624 # PIR D64910 D64910 # Pfam PF10721 DUF2514 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RZPQ_ECOLI Uncharacterized protein RzpQ # RefSeq NP_416071 NC_000913.3 # RefSeq WP_001071769 NZ_LN832404.1 # SIMILARITY To phage N15 gp55. {ECO 0000305}. # eggNOG ENOG4108YV9 Bacteria # eggNOG ENOG4111KD4 LUCA BLAST swissprot:RZPQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RZPQ_ECOLI BioCyc ECOL316407:JW1545-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1545-MONOMER BioCyc EcoCyc:G6826-MONOMER http://biocyc.org/getid?id=EcoCyc:G6826-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3589 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3589 EcoGene EG13828 http://www.ecogene.org/geneInfo.php?eg_id=EG13828 EnsemblBacteria AAC74626 http://www.ensemblgenomes.org/id/AAC74626 EnsemblBacteria AAC74626 http://www.ensemblgenomes.org/id/AAC74626 EnsemblBacteria BAE76468 http://www.ensemblgenomes.org/id/BAE76468 EnsemblBacteria BAE76468 http://www.ensemblgenomes.org/id/BAE76468 EnsemblBacteria BAE76468 http://www.ensemblgenomes.org/id/BAE76468 EnsemblBacteria b1553 http://www.ensemblgenomes.org/id/b1553 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946101 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946101 HOGENOM HOG000127708 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000127708&db=HOGENOM6 InterPro IPR019659 http://www.ebi.ac.uk/interpro/entry/IPR019659 KEGG_Gene ecj:JW1545 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1545 KEGG_Gene eco:b1553 http://www.genome.jp/dbget-bin/www_bget?eco:b1553 OMA CERIYES http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CERIYES PSORT swissprot:RZPQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RZPQ_ECOLI PSORT-B swissprot:RZPQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RZPQ_ECOLI PSORT2 swissprot:RZPQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RZPQ_ECOLI Pfam PF10721 http://pfam.xfam.org/family/PF10721 Phobius swissprot:RZPQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RZPQ_ECOLI ProteinModelPortal P76158 http://www.proteinmodelportal.org/query/uniprot/P76158 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416071 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416071 RefSeq WP_001071769 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001071769 UniProtKB RZPQ_ECOLI http://www.uniprot.org/uniprot/RZPQ_ECOLI UniProtKB-AC P76158 http://www.uniprot.org/uniprot/P76158 charge swissprot:RZPQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RZPQ_ECOLI eggNOG ENOG4108YV9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108YV9 eggNOG ENOG4111KD4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111KD4 epestfind swissprot:RZPQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RZPQ_ECOLI garnier swissprot:RZPQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RZPQ_ECOLI helixturnhelix swissprot:RZPQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RZPQ_ECOLI hmoment swissprot:RZPQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RZPQ_ECOLI iep swissprot:RZPQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RZPQ_ECOLI inforesidue swissprot:RZPQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RZPQ_ECOLI octanol swissprot:RZPQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RZPQ_ECOLI pepcoil swissprot:RZPQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RZPQ_ECOLI pepdigest swissprot:RZPQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RZPQ_ECOLI pepinfo swissprot:RZPQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RZPQ_ECOLI pepnet swissprot:RZPQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RZPQ_ECOLI pepstats swissprot:RZPQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RZPQ_ECOLI pepwheel swissprot:RZPQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RZPQ_ECOLI pepwindow swissprot:RZPQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RZPQ_ECOLI sigcleave swissprot:RZPQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RZPQ_ECOLI ## Database ID URL or Descriptions # AltName MOEB_ECOLI MoaD protein adenylase # AltName MOEB_ECOLI Molybdopterin-converting factor subunit 1 adenylase # AltName MOEB_ECOLI Sulfur carrier protein MoaD adenylyltransferase # BioGrid 4261831 9 # CATALYTIC ACTIVITY ATP + [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly = diphosphate + [molybdopterin-synthase sulfur- carrier protein]-Gly-Gly-AMP. {ECO:0000269|PubMed 11463785}. # COFACTOR MOEB_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 11463785}; Note=Binds 1 zinc ion per subunit. {ECO 0000269|PubMed 11463785}; # EcoGene EG10154 moeB # FUNCTION MOEB_ECOLI Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein MoaD. {ECO 0000269|PubMed 11290749, ECO 0000269|PubMed 11463785}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IBA:GO_Central. # GO_function GO:0005524 ATP binding; IBA:GO_Central. # GO_function GO:0008270 zinc ion binding; IBA:GO_Central. # GO_function GO:0008641 small protein activating enzyme activity; IEA:InterPro. # GO_function GO:0061605 molybdopterin-synthase adenylyltransferase activity; IDA:EcoCyc. # GO_process GO:0006464 cellular protein modification process; IBA:GO_Central. # GO_process GO:0006777 Mo-molybdopterin cofactor biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.720 -; 1. # IntAct P12282 15 # InterPro IPR000594 ThiF_NAD_FAD-bd # InterPro IPR012730 Mopterin_Synthase_Sase_MoeB # InterPro IPR016040 NAD(P)-bd_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko03016 Transfer RNA biogenesis # KEGG_Brite ko04121 Ubiquitin system # KEGG_Pathway ko04122 Sulfur relay system # MASS SPECTROMETRY Mass=26563; Method=Electrospray; Range=1-249; Evidence={ECO:0000269|PubMed 11463785}; # Organism MOEB_ECOLI Escherichia coli (strain K12) # PATHWAY MOEB_ECOLI Cofactor biosynthesis; molybdopterin biosynthesis. # PATRIC 32116855 VBIEscCol129921_0853 # PDB 1JW9 X-ray; 1.70 A; B=1-249 # PDB 1JWA X-ray; 2.90 A; B=1-249 # PDB 1JWB X-ray; 2.10 A; B=1-249 # PIR B32352 B32352 # Pfam PF00899 ThiF # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MOEB_ECOLI Molybdopterin-synthase adenylyltransferase # RefSeq NP_415347 NC_000913.3 # RefSeq WP_000829217 NZ_LN832404.1 # SIMILARITY Belongs to the HesA/MoeB/ThiF family. {ECO 0000305}. # SUBUNIT Homodimer. Forms a stable heterotetrameric complex of 2 MoeB and 2 MoaD during adenylation of MoaD. {ECO:0000269|PubMed 11463785}. # SUPFAM SSF69572 SSF69572 # TIGRFAMs TIGR02355 moeB # eggNOG COG0476 LUCA # eggNOG ENOG4105D06 Bacteria BLAST swissprot:MOEB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MOEB_ECOLI BioCyc ECOL316407:JW0810-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0810-MONOMER BioCyc EcoCyc:EG10154-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10154-MONOMER BioCyc MetaCyc:EG10154-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10154-MONOMER COG COG0476 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0476 DIP DIP-10241N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10241N DOI 10.1038/35104586 http://dx.doi.org/10.1038/35104586 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M102072200 http://dx.doi.org/10.1074/jbc.M102072200 DOI 10.1074/jbc.M102787200 http://dx.doi.org/10.1074/jbc.M102787200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.7.80 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.80 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M21151 http://www.ebi.ac.uk/ena/data/view/M21151 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.7.80 http://enzyme.expasy.org/EC/2.7.7.80 EchoBASE EB0152 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0152 EcoGene EG10154 http://www.ecogene.org/geneInfo.php?eg_id=EG10154 EnsemblBacteria AAC73913 http://www.ensemblgenomes.org/id/AAC73913 EnsemblBacteria AAC73913 http://www.ensemblgenomes.org/id/AAC73913 EnsemblBacteria BAA35514 http://www.ensemblgenomes.org/id/BAA35514 EnsemblBacteria BAA35514 http://www.ensemblgenomes.org/id/BAA35514 EnsemblBacteria BAA35514 http://www.ensemblgenomes.org/id/BAA35514 EnsemblBacteria b0826 http://www.ensemblgenomes.org/id/b0826 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0008641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008641 GO_function GO:0061605 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061605 GO_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GO_process GO:0006777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006777 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 945452 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945452 HOGENOM HOG000281217 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000281217&db=HOGENOM6 InParanoid P12282 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P12282 IntAct P12282 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P12282* IntEnz 2.7.7.80 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.80 InterPro IPR000594 http://www.ebi.ac.uk/interpro/entry/IPR000594 InterPro IPR012730 http://www.ebi.ac.uk/interpro/entry/IPR012730 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Brite ko04121 http://www.genome.jp/dbget-bin/www_bget?ko04121 KEGG_Gene ecj:JW0810 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0810 KEGG_Gene eco:b0826 http://www.genome.jp/dbget-bin/www_bget?eco:b0826 KEGG_Orthology KO:K11996 http://www.genome.jp/dbget-bin/www_bget?KO:K11996 KEGG_Pathway ko04122 http://www.genome.jp/kegg-bin/show_pathway?ko04122 MINT MINT-222244 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-222244 OMA KDNNPHY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KDNNPHY PDB 1JW9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1JW9 PDB 1JWA http://www.ebi.ac.uk/pdbe-srv/view/entry/1JWA PDB 1JWB http://www.ebi.ac.uk/pdbe-srv/view/entry/1JWB PDBsum 1JW9 http://www.ebi.ac.uk/pdbsum/1JW9 PDBsum 1JWA http://www.ebi.ac.uk/pdbsum/1JWA PDBsum 1JWB http://www.ebi.ac.uk/pdbsum/1JWB PSORT swissprot:MOEB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MOEB_ECOLI PSORT-B swissprot:MOEB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MOEB_ECOLI PSORT2 swissprot:MOEB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MOEB_ECOLI Pfam PF00899 http://pfam.xfam.org/family/PF00899 Phobius swissprot:MOEB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MOEB_ECOLI PhylomeDB P12282 http://phylomedb.org/?seqid=P12282 ProteinModelPortal P12282 http://www.proteinmodelportal.org/query/uniprot/P12282 PubMed 11290749 http://www.ncbi.nlm.nih.gov/pubmed/11290749 PubMed 11463785 http://www.ncbi.nlm.nih.gov/pubmed/11463785 PubMed 11713534 http://www.ncbi.nlm.nih.gov/pubmed/11713534 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3045084 http://www.ncbi.nlm.nih.gov/pubmed/3045084 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415347 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415347 RefSeq WP_000829217 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000829217 SMR P12282 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P12282 STRING 511145.b0826 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0826&targetmode=cogs STRING COG0476 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0476&targetmode=cogs SUPFAM SSF69572 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF69572 TIGRFAMs TIGR02355 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02355 UniProtKB MOEB_ECOLI http://www.uniprot.org/uniprot/MOEB_ECOLI UniProtKB-AC P12282 http://www.uniprot.org/uniprot/P12282 charge swissprot:MOEB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MOEB_ECOLI eggNOG COG0476 http://eggnogapi.embl.de/nog_data/html/tree/COG0476 eggNOG ENOG4105D06 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D06 epestfind swissprot:MOEB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MOEB_ECOLI garnier swissprot:MOEB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MOEB_ECOLI helixturnhelix swissprot:MOEB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MOEB_ECOLI hmoment swissprot:MOEB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MOEB_ECOLI iep swissprot:MOEB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MOEB_ECOLI inforesidue swissprot:MOEB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MOEB_ECOLI octanol swissprot:MOEB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MOEB_ECOLI pepcoil swissprot:MOEB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MOEB_ECOLI pepdigest swissprot:MOEB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MOEB_ECOLI pepinfo swissprot:MOEB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MOEB_ECOLI pepnet swissprot:MOEB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MOEB_ECOLI pepstats swissprot:MOEB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MOEB_ECOLI pepwheel swissprot:MOEB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MOEB_ECOLI pepwindow swissprot:MOEB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MOEB_ECOLI sigcleave swissprot:MOEB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MOEB_ECOLI ## Database ID URL or Descriptions # BioGrid 4261001 10 # EcoGene EG12564 yjiC # InterPro IPR021220 DUF2686 # Organism YJIC_ECOLI Escherichia coli (strain K12) # PATRIC 32124248 VBIEscCol129921_4467 # PIR S56550 S56550 # Pfam PF10887 DUF2686 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJIC_ECOLI Uncharacterized protein YjiC # RefSeq NP_418745 NC_000913.3 # RefSeq WP_000062552 NZ_LN832404.1 # SIMILARITY To E.coli YjfZ. {ECO 0000305}. BLAST swissprot:YJIC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJIC_ECOLI BioCyc ECOL316407:JW4288-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4288-MONOMER BioCyc EcoCyc:G7922-MONOMER http://biocyc.org/getid?id=EcoCyc:G7922-MONOMER DIP DIP-12631N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12631N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2452 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2452 EcoGene EG12564 http://www.ecogene.org/geneInfo.php?eg_id=EG12564 EnsemblBacteria AAC77281 http://www.ensemblgenomes.org/id/AAC77281 EnsemblBacteria AAC77281 http://www.ensemblgenomes.org/id/AAC77281 EnsemblBacteria BAE78318 http://www.ensemblgenomes.org/id/BAE78318 EnsemblBacteria BAE78318 http://www.ensemblgenomes.org/id/BAE78318 EnsemblBacteria BAE78318 http://www.ensemblgenomes.org/id/BAE78318 EnsemblBacteria b4325 http://www.ensemblgenomes.org/id/b4325 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 948850 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948850 HOGENOM HOG000009815 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009815&db=HOGENOM6 IntAct P39374 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39374* InterPro IPR021220 http://www.ebi.ac.uk/interpro/entry/IPR021220 KEGG_Gene ecj:JW4288 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4288 KEGG_Gene eco:b4325 http://www.genome.jp/dbget-bin/www_bget?eco:b4325 OMA TETCRES http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TETCRES PSORT swissprot:YJIC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJIC_ECOLI PSORT-B swissprot:YJIC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJIC_ECOLI PSORT2 swissprot:YJIC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJIC_ECOLI Pfam PF10887 http://pfam.xfam.org/family/PF10887 Phobius swissprot:YJIC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJIC_ECOLI ProteinModelPortal P39374 http://www.proteinmodelportal.org/query/uniprot/P39374 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418745 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418745 RefSeq WP_000062552 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000062552 UniProtKB YJIC_ECOLI http://www.uniprot.org/uniprot/YJIC_ECOLI UniProtKB-AC P39374 http://www.uniprot.org/uniprot/P39374 charge swissprot:YJIC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJIC_ECOLI epestfind swissprot:YJIC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJIC_ECOLI garnier swissprot:YJIC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJIC_ECOLI helixturnhelix swissprot:YJIC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJIC_ECOLI hmoment swissprot:YJIC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJIC_ECOLI iep swissprot:YJIC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJIC_ECOLI inforesidue swissprot:YJIC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJIC_ECOLI octanol swissprot:YJIC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJIC_ECOLI pepcoil swissprot:YJIC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJIC_ECOLI pepdigest swissprot:YJIC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJIC_ECOLI pepinfo swissprot:YJIC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJIC_ECOLI pepnet swissprot:YJIC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJIC_ECOLI pepstats swissprot:YJIC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJIC_ECOLI pepwheel swissprot:YJIC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJIC_ECOLI pepwindow swissprot:YJIC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJIC_ECOLI sigcleave swissprot:YJIC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJIC_ECOLI ## Database ID URL or Descriptions # BioGrid 4259189 12 # COFACTOR YPDF_ECOLI Name=Co(2+); Xref=ChEBI CHEBI 48828; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Name=Ni(2+); Xref=ChEBI CHEBI 49786; Note=Co(2+), Mn(2+) or Ni(2+).; # EcoGene EG14153 ypdF # FUNCTION YPDF_ECOLI Hydrolyzes the N-terminal methionine when the next amino acid is alanine, proline or serine. The substrate preference for methionyl aminopeptidase activity is Pro > Ala > Ser. Also able to hydrolyze the Xaa-Pro peptide bond when the first amino acid is alanine, asparagine or methionine. {ECO 0000269|PubMed 15901689}. # GO_function GO:0004177 aminopeptidase activity; IDA:EcoCyc. # GO_process GO:0006508 proteolysis; IDA:EcoCyc. # GOslim_function GO:0008233 peptidase activity # GOslim_process GO:0008150 biological_process # Gene3D 3.40.350.10 -; 1. # Gene3D 3.90.230.10 -; 1. # INTERACTION YPDF_ECOLI P0A6F5 groL; NbExp=2; IntAct=EBI-1128711, EBI-543750; # InterPro IPR000587 Creatinase_N # InterPro IPR000994 Pept_M24 # InterPro IPR001714 Pept_M24_MAP # InterPro IPR028980 Creatinase/Aminopeptidase_P_N # InterPro IPR029149 Creatin/AminoP/Spt16_NTD # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # Organism YPDF_ECOLI Escherichia coli (strain K12) # PATRIC 32120149 VBIEscCol129921_2483 # PDB 5CNX X-ray; 2.60 A; A/B/C=1-361 # PIR F65012 F65012 # PRINTS PR00599 MAPEPTIDASE # Pfam PF00557 Peptidase_M24 # Pfam PF01321 Creatinase_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YPDF_ECOLI Aminopeptidase YpdF # RefSeq NP_416886 NC_000913.3 # RefSeq WP_000173288 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase M24 family. {ECO 0000305}. # SUPFAM SSF53092 SSF53092 # SUPFAM SSF55920 SSF55920 # eggNOG COG0006 LUCA # eggNOG ENOG4105DC7 Bacteria BLAST swissprot:YPDF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YPDF_ECOLI BioCyc ECOL316407:JW2382-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2382-MONOMER BioCyc EcoCyc:G7248-MONOMER http://biocyc.org/getid?id=EcoCyc:G7248-MONOMER BioCyc MetaCyc:G7248-MONOMER http://biocyc.org/getid?id=MetaCyc:G7248-MONOMER COG COG0006 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0006 DIP DIP-48229N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48229N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.187.11.3671-3677.2005 http://dx.doi.org/10.1128/JB.187.11.3671-3677.2005 EC_number EC:3.4.11.- http://www.genome.jp/dbget-bin/www_bget?EC:3.4.11.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.4.11.- http://enzyme.expasy.org/EC/3.4.11.- EchoBASE EB3905 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3905 EcoGene EG14153 http://www.ecogene.org/geneInfo.php?eg_id=EG14153 EnsemblBacteria AAC75444 http://www.ensemblgenomes.org/id/AAC75444 EnsemblBacteria AAC75444 http://www.ensemblgenomes.org/id/AAC75444 EnsemblBacteria BAA16255 http://www.ensemblgenomes.org/id/BAA16255 EnsemblBacteria BAA16255 http://www.ensemblgenomes.org/id/BAA16255 EnsemblBacteria BAA16255 http://www.ensemblgenomes.org/id/BAA16255 EnsemblBacteria b2385 http://www.ensemblgenomes.org/id/b2385 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004177 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004177 GO_process GO:0006508 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006508 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.350.10 http://www.cathdb.info/version/latest/superfamily/3.40.350.10 Gene3D 3.90.230.10 http://www.cathdb.info/version/latest/superfamily/3.90.230.10 GeneID 946853 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946853 HOGENOM HOG000008760 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000008760&db=HOGENOM6 InParanoid P76524 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76524 IntAct P76524 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76524* IntEnz 3.4.11 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.11 InterPro IPR000587 http://www.ebi.ac.uk/interpro/entry/IPR000587 InterPro IPR000994 http://www.ebi.ac.uk/interpro/entry/IPR000994 InterPro IPR001714 http://www.ebi.ac.uk/interpro/entry/IPR001714 InterPro IPR028980 http://www.ebi.ac.uk/interpro/entry/IPR028980 InterPro IPR029149 http://www.ebi.ac.uk/interpro/entry/IPR029149 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW2382 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2382 KEGG_Gene eco:b2385 http://www.genome.jp/dbget-bin/www_bget?eco:b2385 KEGG_Orthology KO:K08326 http://www.genome.jp/dbget-bin/www_bget?KO:K08326 OMA TWCLALF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TWCLALF PDB 5CNX http://www.ebi.ac.uk/pdbe-srv/view/entry/5CNX PDBsum 5CNX http://www.ebi.ac.uk/pdbsum/5CNX PRINTS PR00599 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00599 PSORT swissprot:YPDF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YPDF_ECOLI PSORT-B swissprot:YPDF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YPDF_ECOLI PSORT2 swissprot:YPDF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YPDF_ECOLI Pfam PF00557 http://pfam.xfam.org/family/PF00557 Pfam PF01321 http://pfam.xfam.org/family/PF01321 Phobius swissprot:YPDF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YPDF_ECOLI PhylomeDB P76524 http://phylomedb.org/?seqid=P76524 ProteinModelPortal P76524 http://www.proteinmodelportal.org/query/uniprot/P76524 PubMed 15901689 http://www.ncbi.nlm.nih.gov/pubmed/15901689 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416886 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416886 RefSeq WP_000173288 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000173288 SMR P76524 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76524 STRING 511145.b2385 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2385&targetmode=cogs STRING COG0006 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0006&targetmode=cogs SUPFAM SSF53092 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53092 SUPFAM SSF55920 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55920 UniProtKB YPDF_ECOLI http://www.uniprot.org/uniprot/YPDF_ECOLI UniProtKB-AC P76524 http://www.uniprot.org/uniprot/P76524 charge swissprot:YPDF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YPDF_ECOLI eggNOG COG0006 http://eggnogapi.embl.de/nog_data/html/tree/COG0006 eggNOG ENOG4105DC7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DC7 epestfind swissprot:YPDF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YPDF_ECOLI garnier swissprot:YPDF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YPDF_ECOLI helixturnhelix swissprot:YPDF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YPDF_ECOLI hmoment swissprot:YPDF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YPDF_ECOLI iep swissprot:YPDF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YPDF_ECOLI inforesidue swissprot:YPDF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YPDF_ECOLI octanol swissprot:YPDF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YPDF_ECOLI pepcoil swissprot:YPDF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YPDF_ECOLI pepdigest swissprot:YPDF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YPDF_ECOLI pepinfo swissprot:YPDF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YPDF_ECOLI pepnet swissprot:YPDF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YPDF_ECOLI pepstats swissprot:YPDF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YPDF_ECOLI pepwheel swissprot:YPDF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YPDF_ECOLI pepwindow swissprot:YPDF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YPDF_ECOLI sigcleave swissprot:YPDF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YPDF_ECOLI ## Database ID URL or Descriptions # BioGrid 4262320 131 # CATALYTIC ACTIVITY XDHB_ECOLI Hypoxanthine + NAD(+) + H(2)O = xanthine + NADH. # CATALYTIC ACTIVITY XDHB_ECOLI Xanthine + NAD(+) + H(2)O = urate + NADH. # COFACTOR Name=FAD; Xref=ChEBI:CHEBI 57692; Evidence={ECO:0000250}; # EcoGene EG13050 xdhB # FUNCTION XDHB_ECOLI Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism). # GO_function GO:0004854 xanthine dehydrogenase activity; ISA:EcoliWiki. # GO_function GO:0016614 oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro. # GO_function GO:0071949 FAD binding; ISA:EcoliWiki. # GO_process GO:0006150 hypoxanthine oxidation; IMP:EcoliWiki. # GO_process GO:0006166 purine ribonucleoside salvage; IEA:UniProtKB-KW. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.30.43.10 -; 1. # Gene3D 3.30.465.10 -; 1. # IntAct Q46800 5 # InterPro IPR002346 Mopterin_DH_FAD-bd # InterPro IPR005107 CO_DH_flav_C # InterPro IPR016166 FAD-bd_2 # InterPro IPR016167 FAD-bd_2_sub1 # InterPro IPR016169 CO_DH_flavot_FAD-bd_sub2 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # Organism XDHB_ECOLI Escherichia coli (strain K12) # PATHWAY Purine metabolism; hypoxanthine degradation; urate from hypoxanthine step 1/2. # PATHWAY Purine metabolism; hypoxanthine degradation; urate from hypoxanthine step 2/2. # PATRIC 32121144 VBIEscCol129921_2960 # PIR C65070 C65070 # PROSITE PS51387 FAD_PCMH # Pfam PF00941 FAD_binding_5 # Pfam PF03450 CO_deh_flav_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName XDHB_ECOLI Xanthine dehydrogenase FAD-binding subunit # RefSeq NP_417343 NC_000913.3 # RefSeq WP_000459182 NZ_LN832404.1 # SIMILARITY Contains 1 FAD-binding PCMH-type domain. {ECO:0000255|PROSITE-ProRule PRU00718}. # SMART SM01092 CO_deh_flav_C # SUBUNIT Heterotrimer of XdhA, XdhB and XdhC. {ECO 0000305}. # SUPFAM SSF55447 SSF55447 # SUPFAM SSF56176 SSF56176 # UniPathway UPA00604 UER00661 # UniPathway UPA00604 UER00662 # eggNOG COG1319 LUCA # eggNOG ENOG4108HR6 Bacteria BLAST swissprot:XDHB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:XDHB_ECOLI BioCyc ECOL316407:JW2835-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2835-MONOMER BioCyc EcoCyc:G7486-MONOMER http://biocyc.org/getid?id=EcoCyc:G7486-MONOMER BioCyc MetaCyc:G7486-MONOMER http://biocyc.org/getid?id=MetaCyc:G7486-MONOMER COG COG1319 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1319 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.19.5332-5341.2000 http://dx.doi.org/10.1128/JB.182.19.5332-5341.2000 EC_number EC:1.17.1.4 http://www.genome.jp/dbget-bin/www_bget?EC:1.17.1.4 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 ENZYME 1.17.1.4 http://enzyme.expasy.org/EC/1.17.1.4 EchoBASE EB2862 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2862 EcoGene EG13050 http://www.ecogene.org/geneInfo.php?eg_id=EG13050 EnsemblBacteria AAC75905 http://www.ensemblgenomes.org/id/AAC75905 EnsemblBacteria AAC75905 http://www.ensemblgenomes.org/id/AAC75905 EnsemblBacteria BAE76933 http://www.ensemblgenomes.org/id/BAE76933 EnsemblBacteria BAE76933 http://www.ensemblgenomes.org/id/BAE76933 EnsemblBacteria BAE76933 http://www.ensemblgenomes.org/id/BAE76933 EnsemblBacteria b2867 http://www.ensemblgenomes.org/id/b2867 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004854 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004854 GO_function GO:0016614 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016614 GO_function GO:0071949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071949 GO_process GO:0006150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006150 GO_process GO:0006166 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006166 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.30.43.10 http://www.cathdb.info/version/latest/superfamily/3.30.43.10 Gene3D 3.30.465.10 http://www.cathdb.info/version/latest/superfamily/3.30.465.10 GeneID 947205 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947205 HOGENOM HOG000244729 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000244729&db=HOGENOM6 InParanoid Q46800 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46800 IntAct Q46800 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46800* IntEnz 1.17.1.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.17.1.4 InterPro IPR002346 http://www.ebi.ac.uk/interpro/entry/IPR002346 InterPro IPR005107 http://www.ebi.ac.uk/interpro/entry/IPR005107 InterPro IPR016166 http://www.ebi.ac.uk/interpro/entry/IPR016166 InterPro IPR016167 http://www.ebi.ac.uk/interpro/entry/IPR016167 InterPro IPR016169 http://www.ebi.ac.uk/interpro/entry/IPR016169 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2835 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2835 KEGG_Gene eco:b2867 http://www.genome.jp/dbget-bin/www_bget?eco:b2867 KEGG_Orthology KO:K13479 http://www.genome.jp/dbget-bin/www_bget?KO:K13479 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Reaction rn:R01768 http://www.genome.jp/dbget-bin/www_bget?rn:R01768 KEGG_Reaction rn:R02103 http://www.genome.jp/dbget-bin/www_bget?rn:R02103 OMA MVEINFD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MVEINFD PROSITE PS51387 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51387 PSORT swissprot:XDHB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:XDHB_ECOLI PSORT-B swissprot:XDHB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:XDHB_ECOLI PSORT2 swissprot:XDHB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:XDHB_ECOLI Pfam PF00941 http://pfam.xfam.org/family/PF00941 Pfam PF03450 http://pfam.xfam.org/family/PF03450 Phobius swissprot:XDHB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:XDHB_ECOLI PhylomeDB Q46800 http://phylomedb.org/?seqid=Q46800 ProteinModelPortal Q46800 http://www.proteinmodelportal.org/query/uniprot/Q46800 PubMed 10986234 http://www.ncbi.nlm.nih.gov/pubmed/10986234 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417343 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417343 RefSeq WP_000459182 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000459182 SMART SM01092 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01092 SMR Q46800 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46800 STRING 511145.b2867 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2867&targetmode=cogs STRING COG1319 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1319&targetmode=cogs SUPFAM SSF55447 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55447 SUPFAM SSF56176 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56176 UniProtKB XDHB_ECOLI http://www.uniprot.org/uniprot/XDHB_ECOLI UniProtKB-AC Q46800 http://www.uniprot.org/uniprot/Q46800 charge swissprot:XDHB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:XDHB_ECOLI eggNOG COG1319 http://eggnogapi.embl.de/nog_data/html/tree/COG1319 eggNOG ENOG4108HR6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108HR6 epestfind swissprot:XDHB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:XDHB_ECOLI garnier swissprot:XDHB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:XDHB_ECOLI helixturnhelix swissprot:XDHB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:XDHB_ECOLI hmoment swissprot:XDHB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:XDHB_ECOLI iep swissprot:XDHB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:XDHB_ECOLI inforesidue swissprot:XDHB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:XDHB_ECOLI octanol swissprot:XDHB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:XDHB_ECOLI pepcoil swissprot:XDHB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:XDHB_ECOLI pepdigest swissprot:XDHB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:XDHB_ECOLI pepinfo swissprot:XDHB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:XDHB_ECOLI pepnet swissprot:XDHB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:XDHB_ECOLI pepstats swissprot:XDHB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:XDHB_ECOLI pepwheel swissprot:XDHB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:XDHB_ECOLI pepwindow swissprot:XDHB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:XDHB_ECOLI sigcleave swissprot:XDHB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:XDHB_ECOLI ## Database ID URL or Descriptions # AltName HTPG_ECOLI Heat shock protein C62.5 # AltName HTPG_ECOLI Heat shock protein HtpG # AltName HTPG_ECOLI High temperature protein G # BioGrid 4261971 197 # EcoGene EG10461 htpG # FUNCTION HTPG_ECOLI Molecular chaperone. Has ATPase activity. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0016887 ATPase activity; IDA:CACAO. # GO_function GO:0042623 ATPase activity, coupled; IDA:EcoCyc. # GO_process GO:0006457 protein folding; EXP:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0009408 response to heat; IEP:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006457 protein folding # GOslim_process GO:0006950 response to stress # Gene3D 3.30.565.10 -; 1. # HAMAP MF_00505 HSP90 # INTERACTION HTPG_ECOLI Self; NbExp=2; IntAct=EBI-369221, EBI-369221; P0A6Y8 dnaK; NbExp=3; IntAct=EBI-369221, EBI-542092; P0A8T7 rpoC; NbExp=2; IntAct=EBI-369221, EBI-543604; # IntAct P0A6Z3 61 # InterPro IPR001404 Hsp90_fam # InterPro IPR003594 HATPase_C # InterPro IPR019805 Heat_shock_protein_90_CS # InterPro IPR020568 Ribosomal_S5_D2-typ_fold # InterPro IPR020575 Hsp90_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko03051 Proteasome # KEGG_Brite ko03110 Chaperones and folding catalysts # KEGG_Pathway ko04141 Protein processing in endoplasmic reticulum # KEGG_Pathway ko04151 PI3K-Akt signaling pathway # KEGG_Pathway ko04612 Antigen processing and presentation # KEGG_Pathway ko04621 NOD-like receptor signaling pathway # KEGG_Pathway ko04626 Plant-pathogen interaction # KEGG_Pathway ko04914 Progesterone-mediated oocyte maturation # KEGG_Pathway ko05200 Pathways in cancer # KEGG_Pathway ko05215 Prostate cancer # Organism HTPG_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11528 PTHR11528 # PATRIC 32116103 VBIEscCol129921_0493 # PDB 1SF8 X-ray; 2.60 A; A/B/C/D/E/F/G/H=511-624 # PDB 1Y4S X-ray; 2.90 A; A/B=1-559 # PDB 1Y4U X-ray; 2.90 A; A/B=1-559 # PDB 2GQ0 X-ray; 1.90 A; A/B=230-495 # PDB 2IOP X-ray; 3.55 A; A/B/C/D=1-624 # PDB 2IOQ X-ray; 3.50 A; A/B=1-624 # PDB 2IOR X-ray; 1.65 A; A=1-215 # PIR A28324 HHEC62 # PIRSF PIRSF002583 Hsp90 # PRINTS PR00775 HEATSHOCK90 # PROSITE PS00298 HSP90 # PTM HTPG_ECOLI Phosphorylated. {ECO 0000269|PubMed 2647735}. # Pfam PF00183 HSP90 # Pfam PF02518 HATPase_c # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HTPG_ECOLI Chaperone protein HtpG # RefSeq NP_415006 NC_000913.3 # RefSeq WP_000678201 NZ_CP014272.1 # SIMILARITY Belongs to the heat shock protein 90 family. {ECO 0000305}. # SMART SM00387 HATPase_c # SUBCELLULAR LOCATION HTPG_ECOLI Cytoplasm {ECO 0000269|PubMed 16079137}. Cell inner membrane {ECO 0000269|PubMed 16079137}; Peripheral membrane protein {ECO 0000269|PubMed 16079137}. # SUBUNIT HTPG_ECOLI Homodimer. Oligomerizes at 65 degrees Celsius. {ECO 0000269|PubMed 15837196, ECO 0000269|PubMed 17055434, ECO 0000269|PubMed 2647735}. # SUPFAM SSF54211 SSF54211 # SUPFAM SSF55874 SSF55874 # eggNOG COG0326 LUCA # eggNOG ENOG4105CJX Bacteria BLAST swissprot:HTPG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HTPG_ECOLI BioCyc ECOL316407:JW0462-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0462-MONOMER BioCyc EcoCyc:EG10461-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10461-MONOMER COG COG0326 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0326 DIP DIP-29797N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-29797N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1016/j.cell.2006.09.027 http://dx.doi.org/10.1016/j.cell.2006.09.027 DOI 10.1016/j.str.2004.03.020 http://dx.doi.org/10.1016/j.str.2004.03.020 DOI 10.1016/j.str.2004.12.018 http://dx.doi.org/10.1016/j.str.2004.12.018 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/0264-6021:3540663 http://dx.doi.org/10.1042/0264-6021:3540663 DOI 10.1046/j.0014-2956.2001.02457.x http://dx.doi.org/10.1046/j.0014-2956.2001.02457.x DOI 10.1073/pnas.84.15.5177 http://dx.doi.org/10.1073/pnas.84.15.5177 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M38777 http://www.ebi.ac.uk/ena/data/view/M38777 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EchoBASE EB0456 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0456 EcoGene EG10461 http://www.ecogene.org/geneInfo.php?eg_id=EG10461 EnsemblBacteria AAC73575 http://www.ensemblgenomes.org/id/AAC73575 EnsemblBacteria AAC73575 http://www.ensemblgenomes.org/id/AAC73575 EnsemblBacteria BAE76252 http://www.ensemblgenomes.org/id/BAE76252 EnsemblBacteria BAE76252 http://www.ensemblgenomes.org/id/BAE76252 EnsemblBacteria BAE76252 http://www.ensemblgenomes.org/id/BAE76252 EnsemblBacteria b0473 http://www.ensemblgenomes.org/id/b0473 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_function GO:0042623 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042623 GO_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.30.565.10 http://www.cathdb.info/version/latest/superfamily/3.30.565.10 GeneID 945099 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945099 HAMAP MF_00505 http://hamap.expasy.org/unirule/MF_00505 HOGENOM HOG000031989 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000031989&db=HOGENOM6 InParanoid P0A6Z3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6Z3 IntAct P0A6Z3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6Z3* InterPro IPR001404 http://www.ebi.ac.uk/interpro/entry/IPR001404 InterPro IPR003594 http://www.ebi.ac.uk/interpro/entry/IPR003594 InterPro IPR019805 http://www.ebi.ac.uk/interpro/entry/IPR019805 InterPro IPR020568 http://www.ebi.ac.uk/interpro/entry/IPR020568 InterPro IPR020575 http://www.ebi.ac.uk/interpro/entry/IPR020575 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko03051 http://www.genome.jp/dbget-bin/www_bget?ko03051 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW0462 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0462 KEGG_Gene eco:b0473 http://www.genome.jp/dbget-bin/www_bget?eco:b0473 KEGG_Orthology KO:K04079 http://www.genome.jp/dbget-bin/www_bget?KO:K04079 KEGG_Pathway ko04141 http://www.genome.jp/kegg-bin/show_pathway?ko04141 KEGG_Pathway ko04151 http://www.genome.jp/kegg-bin/show_pathway?ko04151 KEGG_Pathway ko04612 http://www.genome.jp/kegg-bin/show_pathway?ko04612 KEGG_Pathway ko04621 http://www.genome.jp/kegg-bin/show_pathway?ko04621 KEGG_Pathway ko04626 http://www.genome.jp/kegg-bin/show_pathway?ko04626 KEGG_Pathway ko04914 http://www.genome.jp/kegg-bin/show_pathway?ko04914 KEGG_Pathway ko05200 http://www.genome.jp/kegg-bin/show_pathway?ko05200 KEGG_Pathway ko05215 http://www.genome.jp/kegg-bin/show_pathway?ko05215 MINT MINT-1227806 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1227806 OMA YLRFMRG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YLRFMRG PANTHER PTHR11528 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11528 PDB 1SF8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1SF8 PDB 1Y4S http://www.ebi.ac.uk/pdbe-srv/view/entry/1Y4S PDB 1Y4U http://www.ebi.ac.uk/pdbe-srv/view/entry/1Y4U PDB 2GQ0 http://www.ebi.ac.uk/pdbe-srv/view/entry/2GQ0 PDB 2IOP http://www.ebi.ac.uk/pdbe-srv/view/entry/2IOP PDB 2IOQ http://www.ebi.ac.uk/pdbe-srv/view/entry/2IOQ PDB 2IOR http://www.ebi.ac.uk/pdbe-srv/view/entry/2IOR PDBsum 1SF8 http://www.ebi.ac.uk/pdbsum/1SF8 PDBsum 1Y4S http://www.ebi.ac.uk/pdbsum/1Y4S PDBsum 1Y4U http://www.ebi.ac.uk/pdbsum/1Y4U PDBsum 2GQ0 http://www.ebi.ac.uk/pdbsum/2GQ0 PDBsum 2IOP http://www.ebi.ac.uk/pdbsum/2IOP PDBsum 2IOQ http://www.ebi.ac.uk/pdbsum/2IOQ PDBsum 2IOR http://www.ebi.ac.uk/pdbsum/2IOR PRINTS PR00775 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00775 PROSITE PS00298 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00298 PSORT swissprot:HTPG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HTPG_ECOLI PSORT-B swissprot:HTPG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HTPG_ECOLI PSORT2 swissprot:HTPG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HTPG_ECOLI Pfam PF00183 http://pfam.xfam.org/family/PF00183 Pfam PF02518 http://pfam.xfam.org/family/PF02518 Phobius swissprot:HTPG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HTPG_ECOLI PhylomeDB P0A6Z3 http://phylomedb.org/?seqid=P0A6Z3 ProteinModelPortal P0A6Z3 http://www.proteinmodelportal.org/query/uniprot/P0A6Z3 PubMed 11237871 http://www.ncbi.nlm.nih.gov/pubmed/11237871 PubMed 11606187 http://www.ncbi.nlm.nih.gov/pubmed/11606187 PubMed 15274928 http://www.ncbi.nlm.nih.gov/pubmed/15274928 PubMed 15837196 http://www.ncbi.nlm.nih.gov/pubmed/15837196 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17055434 http://www.ncbi.nlm.nih.gov/pubmed/17055434 PubMed 2647735 http://www.ncbi.nlm.nih.gov/pubmed/2647735 PubMed 3299380 http://www.ncbi.nlm.nih.gov/pubmed/3299380 PubMed 8419347 http://www.ncbi.nlm.nih.gov/pubmed/8419347 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_415006 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415006 RefSeq WP_000678201 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000678201 SMART SM00387 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00387 SMR P0A6Z3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6Z3 STRING 511145.b0473 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0473&targetmode=cogs STRING COG0326 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0326&targetmode=cogs SUPFAM SSF54211 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54211 SUPFAM SSF55874 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55874 SWISS-2DPAGE P0A6Z3 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A6Z3 UniProtKB HTPG_ECOLI http://www.uniprot.org/uniprot/HTPG_ECOLI UniProtKB-AC P0A6Z3 http://www.uniprot.org/uniprot/P0A6Z3 charge swissprot:HTPG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HTPG_ECOLI eggNOG COG0326 http://eggnogapi.embl.de/nog_data/html/tree/COG0326 eggNOG ENOG4105CJX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CJX epestfind swissprot:HTPG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HTPG_ECOLI garnier swissprot:HTPG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HTPG_ECOLI helixturnhelix swissprot:HTPG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HTPG_ECOLI hmoment swissprot:HTPG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HTPG_ECOLI iep swissprot:HTPG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HTPG_ECOLI inforesidue swissprot:HTPG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HTPG_ECOLI octanol swissprot:HTPG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HTPG_ECOLI pepcoil swissprot:HTPG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HTPG_ECOLI pepdigest swissprot:HTPG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HTPG_ECOLI pepinfo swissprot:HTPG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HTPG_ECOLI pepnet swissprot:HTPG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HTPG_ECOLI pepstats swissprot:HTPG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HTPG_ECOLI pepwheel swissprot:HTPG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HTPG_ECOLI pepwindow swissprot:HTPG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HTPG_ECOLI sigcleave swissprot:HTPG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HTPG_ECOLI ## Database ID URL or Descriptions # BioGrid 4260882 80 # CATALYTIC ACTIVITY RUVB_ECOLI ATP + H(2)O = ADP + phosphate. {ECO 0000255|HAMAP-Rule MF_00016, ECO 0000269|PubMed 8433990}. # ENZYME REGULATION RuvB possesses weak ATPase activity, which is stimulated by the RuvA protein in the presence of DNA. {ECO:0000269|PubMed 8433990}. # EcoGene EG10924 ruvB # FUNCTION RUVB_ECOLI The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. {ECO 0000255|HAMAP-Rule MF_00016, ECO 0000269|PubMed 8433990}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0048476 Holliday junction resolvase complex; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_function GO:0004003 ATP-dependent DNA helicase activity; IDA:CACAO. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0009378 four-way junction helicase activity; IDA:EcoCyc. # GO_process GO:0000725 recombinational repair; IMP:EcoCyc. # GO_process GO:0009432 SOS response; IEP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004386 helicase activity # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # Gene3D 1.10.10.10 -; 1. # Gene3D 3.40.50.300 -; 1. # HAMAP MF_00016 DNA_helic_RuvB # INDUCTION RUVB_ECOLI Expression of the ruv region is induced by damage to DNA and is regulated by LexA as part of the SOS response. RuvA and RuvB are also involved in mutagenesis induced by UV and X irradiation and by some chemicals (PubMed 3279394). Induced by hydroxyurea (PubMed 20005847). {ECO 0000269|PubMed 20005847, ECO 0000269|PubMed 3279394}. # IntAct P0A812 15 # InterPro IPR003593 AAA+_ATPase # InterPro IPR004605 DNA_helicase_Holl-junc_RuvB # InterPro IPR008823 DNA_helicase_Holl-junc_RuvB_C # InterPro IPR008824 RuvB_N # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko03440 Homologous recombination # Organism RUVB_ECOLI Escherichia coli (strain K12) # PATRIC 32119043 VBIEscCol129921_1939 # PIR B28533 BVECVB # Pfam PF05491 RuvB_C # Pfam PF05496 RuvB_N # ProDom PD005323 DNA_helicase_Holl-junc_RuvB_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Holliday junction ATP-dependent DNA helicase RuvB {ECO:0000255|HAMAP-Rule MF_00016} # RefSeq NP_416374 NC_000913.3 # RefSeq WP_000568519 NZ_LN832404.1 # SIMILARITY Belongs to the RuvB family. {ECO:0000255|HAMAP- Rule MF_00016}. # SMART SM00382 AAA # SUBCELLULAR LOCATION RUVB_ECOLI Cytoplasm {ECO 0000269|PubMed 21219465}. Note=In 15% of cell localizes to discrete nucleoid foci (probable DNA damage sites) upon treatment with mitomycin C (MMC) for 2 hours. # SUBUNIT Homododecamer composed of two hexameric rings; when bound to DNA in the presence of ATP and magnesium. Forms a complex with RuvA. Interacts with YgbT (Cas1). {ECO:0000269|PubMed 21219465}. # SUPFAM SSF46785 SSF46785 # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR00635 ruvB # eggNOG COG2255 LUCA # eggNOG ENOG4105CKJ Bacteria BLAST swissprot:RUVB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RUVB_ECOLI BioCyc ECOL316407:JW1849-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1849-MONOMER BioCyc EcoCyc:EG10924-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10924-MONOMER BioCyc MetaCyc:EG10924-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10924-MONOMER COG COG2255 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2255 DIP DIP-47870N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47870N DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.90.4.1315 http://dx.doi.org/10.1073/pnas.90.4.1315 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/nar/16.4.1541 http://dx.doi.org/10.1093/nar/16.4.1541 DOI 10.1111/j.1365-2958.2010.07465.x http://dx.doi.org/10.1111/j.1365-2958.2010.07465.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1146/annurev.genet.31.1.213 http://dx.doi.org/10.1146/annurev.genet.31.1.213 EC_number EC:3.6.4.12 {ECO:0000255|HAMAP-Rule:MF_00016} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.4.12 {ECO:0000255|HAMAP-Rule:MF_00016} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M21298 http://www.ebi.ac.uk/ena/data/view/M21298 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X07091 http://www.ebi.ac.uk/ena/data/view/X07091 ENZYME 3.6.4.12 {ECO:0000255|HAMAP-Rule:MF_00016} http://enzyme.expasy.org/EC/3.6.4.12 {ECO:0000255|HAMAP-Rule:MF_00016} EchoBASE EB0917 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0917 EcoGene EG10924 http://www.ecogene.org/geneInfo.php?eg_id=EG10924 EnsemblBacteria AAC74930 http://www.ensemblgenomes.org/id/AAC74930 EnsemblBacteria AAC74930 http://www.ensemblgenomes.org/id/AAC74930 EnsemblBacteria BAA15671 http://www.ensemblgenomes.org/id/BAA15671 EnsemblBacteria BAA15671 http://www.ensemblgenomes.org/id/BAA15671 EnsemblBacteria BAA15671 http://www.ensemblgenomes.org/id/BAA15671 EnsemblBacteria b1860 http://www.ensemblgenomes.org/id/b1860 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0048476 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048476 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004003 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004003 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0009378 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009378 GO_process GO:0000725 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000725 GO_process GO:0009432 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009432 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004386 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 946371 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946371 HAMAP MF_00016 http://hamap.expasy.org/unirule/MF_00016 HOGENOM HOG000218623 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218623&db=HOGENOM6 InParanoid P0A812 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A812 IntAct P0A812 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A812* IntEnz 3.6.4.12 {ECO:0000255|HAMAP-Rule:MF_00016} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.4.12 {ECO:0000255|HAMAP-Rule:MF_00016} InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR004605 http://www.ebi.ac.uk/interpro/entry/IPR004605 InterPro IPR008823 http://www.ebi.ac.uk/interpro/entry/IPR008823 InterPro IPR008824 http://www.ebi.ac.uk/interpro/entry/IPR008824 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW1849 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1849 KEGG_Gene eco:b1860 http://www.genome.jp/dbget-bin/www_bget?eco:b1860 KEGG_Orthology KO:K03551 http://www.genome.jp/dbget-bin/www_bget?KO:K03551 KEGG_Pathway ko03440 http://www.genome.jp/kegg-bin/show_pathway?ko03440 MINT MINT-1266054 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1266054 OMA YEPYLMQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YEPYLMQ PSORT swissprot:RUVB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RUVB_ECOLI PSORT-B swissprot:RUVB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RUVB_ECOLI PSORT2 swissprot:RUVB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RUVB_ECOLI Pfam PF05491 http://pfam.xfam.org/family/PF05491 Pfam PF05496 http://pfam.xfam.org/family/PF05496 Phobius swissprot:RUVB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RUVB_ECOLI PhylomeDB P0A812 http://phylomedb.org/?seqid=P0A812 ProteinModelPortal P0A812 http://www.proteinmodelportal.org/query/uniprot/P0A812 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 21219465 http://www.ncbi.nlm.nih.gov/pubmed/21219465 PubMed 2842314 http://www.ncbi.nlm.nih.gov/pubmed/2842314 PubMed 3279394 http://www.ncbi.nlm.nih.gov/pubmed/3279394 PubMed 8433990 http://www.ncbi.nlm.nih.gov/pubmed/8433990 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9442895 http://www.ncbi.nlm.nih.gov/pubmed/9442895 RefSeq NP_416374 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416374 RefSeq WP_000568519 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000568519 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P0A812 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A812 STRING 511145.b1860 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1860&targetmode=cogs STRING COG2255 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2255&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR00635 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00635 UniProtKB RUVB_ECOLI http://www.uniprot.org/uniprot/RUVB_ECOLI UniProtKB-AC P0A812 http://www.uniprot.org/uniprot/P0A812 charge swissprot:RUVB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RUVB_ECOLI eggNOG COG2255 http://eggnogapi.embl.de/nog_data/html/tree/COG2255 eggNOG ENOG4105CKJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CKJ epestfind swissprot:RUVB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RUVB_ECOLI garnier swissprot:RUVB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RUVB_ECOLI helixturnhelix swissprot:RUVB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RUVB_ECOLI hmoment swissprot:RUVB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RUVB_ECOLI iep swissprot:RUVB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RUVB_ECOLI inforesidue swissprot:RUVB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RUVB_ECOLI octanol swissprot:RUVB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RUVB_ECOLI pepcoil swissprot:RUVB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RUVB_ECOLI pepdigest swissprot:RUVB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RUVB_ECOLI pepinfo swissprot:RUVB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RUVB_ECOLI pepnet swissprot:RUVB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RUVB_ECOLI pepstats swissprot:RUVB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RUVB_ECOLI pepwheel swissprot:RUVB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RUVB_ECOLI pepwindow swissprot:RUVB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RUVB_ECOLI sigcleave swissprot:RUVB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RUVB_ECOLI ## Database ID URL or Descriptions # AltName RECE_ECOLI Exodeoxyribonuclease VIII # BioGrid 4260163 103 # CATALYTIC ACTIVITY RECE_ECOLI Degradation of double-stranded DNA. It acts progressively in a 5' to 3' direction, releasing 5'- phosphomononucleotides. # EcoGene EG10827 recE # FUNCTION RECE_ECOLI Is involved in the RecE pathway of recombination. Has a strong preference for linear duplex substrate DNA and appears to be unable to initiate degradation from single-stranded breaks in DNA. # GO_function GO:0051908 double-stranded DNA 5'-3' exodeoxyribonuclease activity; IDA:EcoCyc. # GOslim_function GO:0004518 nuclease activity # IntAct P15032 11 # InterPro IPR010584 ExoDNase_VIII # InterPro IPR024432 Put_RecE_PDDEXK-like_dom # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # Organism RECE_ECOLI Escherichia coli (strain K12) # PATRIC 32117978 VBIEscCol129921_1409 # PDB 3H4R X-ray; 2.80 A; A=606-866 # PIR A64885 NCECX8 # Pfam PF06630 Exonuc_VIII # Pfam PF12684 DUF3799 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RECE_ECOLI Exodeoxyribonuclease 8 # RefSeq NP_415866 NC_000913.3 # RefSeq WP_000105143 NZ_CP014272.1 # SUBUNIT RECE_ECOLI Homotetramer. # eggNOG ENOG41076J9 Bacteria # eggNOG ENOG410XPW2 LUCA BLAST swissprot:RECE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RECE_ECOLI BioCyc ECOL316407:JW1344-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1344-MONOMER BioCyc EcoCyc:EG10827-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10827-MONOMER BioCyc MetaCyc:EG10827-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10827-MONOMER DIP DIP-10652N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10652N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.11.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.11.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L23927 http://www.ebi.ac.uk/ena/data/view/L23927 EMBL M24905 http://www.ebi.ac.uk/ena/data/view/M24905 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X55956 http://www.ebi.ac.uk/ena/data/view/X55956 EMBL X55956 http://www.ebi.ac.uk/ena/data/view/X55956 EMBL X55956 http://www.ebi.ac.uk/ena/data/view/X55956 EMBL X55956 http://www.ebi.ac.uk/ena/data/view/X55956 EMBL X55956 http://www.ebi.ac.uk/ena/data/view/X55956 ENZYME 3.1.11.- http://enzyme.expasy.org/EC/3.1.11.- EchoBASE EB0820 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0820 EcoGene EG10827 http://www.ecogene.org/geneInfo.php?eg_id=EG10827 EnsemblBacteria AAC74432 http://www.ensemblgenomes.org/id/AAC74432 EnsemblBacteria AAC74432 http://www.ensemblgenomes.org/id/AAC74432 EnsemblBacteria BAA14950 http://www.ensemblgenomes.org/id/BAA14950 EnsemblBacteria BAA14950 http://www.ensemblgenomes.org/id/BAA14950 EnsemblBacteria BAA14950 http://www.ensemblgenomes.org/id/BAA14950 EnsemblBacteria b1350 http://www.ensemblgenomes.org/id/b1350 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0051908 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051908 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GeneID 945918 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945918 HOGENOM HOG000120165 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120165&db=HOGENOM6 IntAct P15032 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P15032* IntEnz 3.1.11 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.11 InterPro IPR010584 http://www.ebi.ac.uk/interpro/entry/IPR010584 InterPro IPR024432 http://www.ebi.ac.uk/interpro/entry/IPR024432 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW1344 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1344 KEGG_Gene eco:b1350 http://www.genome.jp/dbget-bin/www_bget?eco:b1350 KEGG_Orthology KO:K10906 http://www.genome.jp/dbget-bin/www_bget?KO:K10906 MINT MINT-1262359 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1262359 OMA WKFTSAN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WKFTSAN PDB 3H4R http://www.ebi.ac.uk/pdbe-srv/view/entry/3H4R PDBsum 3H4R http://www.ebi.ac.uk/pdbsum/3H4R PSORT swissprot:RECE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RECE_ECOLI PSORT-B swissprot:RECE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RECE_ECOLI PSORT2 swissprot:RECE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RECE_ECOLI Pfam PF06630 http://pfam.xfam.org/family/PF06630 Pfam PF12684 http://pfam.xfam.org/family/PF12684 Phobius swissprot:RECE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RECE_ECOLI ProteinModelPortal P15032 http://www.proteinmodelportal.org/query/uniprot/P15032 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2199308 http://www.ncbi.nlm.nih.gov/pubmed/2199308 PubMed 2649487 http://www.ncbi.nlm.nih.gov/pubmed/2649487 PubMed 8244937 http://www.ncbi.nlm.nih.gov/pubmed/8244937 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415866 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415866 RefSeq WP_000105143 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000105143 SMR P15032 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P15032 STRING 511145.b1350 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1350&targetmode=cogs UniProtKB RECE_ECOLI http://www.uniprot.org/uniprot/RECE_ECOLI UniProtKB-AC P15032 http://www.uniprot.org/uniprot/P15032 charge swissprot:RECE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RECE_ECOLI eggNOG ENOG41076J9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41076J9 eggNOG ENOG410XPW2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPW2 epestfind swissprot:RECE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RECE_ECOLI garnier swissprot:RECE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RECE_ECOLI helixturnhelix swissprot:RECE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RECE_ECOLI hmoment swissprot:RECE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RECE_ECOLI iep swissprot:RECE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RECE_ECOLI inforesidue swissprot:RECE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RECE_ECOLI octanol swissprot:RECE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RECE_ECOLI pepcoil swissprot:RECE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RECE_ECOLI pepdigest swissprot:RECE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RECE_ECOLI pepinfo swissprot:RECE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RECE_ECOLI pepnet swissprot:RECE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RECE_ECOLI pepstats swissprot:RECE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RECE_ECOLI pepwheel swissprot:RECE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RECE_ECOLI pepwindow swissprot:RECE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RECE_ECOLI sigcleave swissprot:RECE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RECE_ECOLI ## Database ID URL or Descriptions # BioGrid 4262758 7 # EcoGene EG12575 yjiN # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR007383 DUF445 # Organism YJIN_ECOLI Escherichia coli (strain K12) # PATRIC 32124278 VBIEscCol129921_4482 # PIR S56561 S56561 # Pfam PF04286 DUF445 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJIN_ECOLI Uncharacterized protein YjiN # RefSeq NP_418756 NC_000913.3 # RefSeq WP_001037419 NZ_LN832404.1 # SUBCELLULAR LOCATION YJIN_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # eggNOG COG2733 LUCA # eggNOG ENOG4106BRA Bacteria BLAST swissprot:YJIN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJIN_ECOLI BioCyc ECOL316407:JW4299-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4299-MONOMER BioCyc EcoCyc:G7933-MONOMER http://biocyc.org/getid?id=EcoCyc:G7933-MONOMER DIP DIP-12640N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12640N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2463 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2463 EcoGene EG12575 http://www.ecogene.org/geneInfo.php?eg_id=EG12575 EnsemblBacteria AAC77292 http://www.ensemblgenomes.org/id/AAC77292 EnsemblBacteria AAC77292 http://www.ensemblgenomes.org/id/AAC77292 EnsemblBacteria BAE78329 http://www.ensemblgenomes.org/id/BAE78329 EnsemblBacteria BAE78329 http://www.ensemblgenomes.org/id/BAE78329 EnsemblBacteria BAE78329 http://www.ensemblgenomes.org/id/BAE78329 EnsemblBacteria b4336 http://www.ensemblgenomes.org/id/b4336 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 948860 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948860 HOGENOM HOG000150757 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000150757&db=HOGENOM6 InParanoid P39385 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39385 IntAct P39385 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39385* InterPro IPR007383 http://www.ebi.ac.uk/interpro/entry/IPR007383 KEGG_Gene ecj:JW4299 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4299 KEGG_Gene eco:b4336 http://www.genome.jp/dbget-bin/www_bget?eco:b4336 OMA WGPPIGR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WGPPIGR PSORT swissprot:YJIN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJIN_ECOLI PSORT-B swissprot:YJIN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJIN_ECOLI PSORT2 swissprot:YJIN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJIN_ECOLI Pfam PF04286 http://pfam.xfam.org/family/PF04286 Phobius swissprot:YJIN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJIN_ECOLI PhylomeDB P39385 http://phylomedb.org/?seqid=P39385 ProteinModelPortal P39385 http://www.proteinmodelportal.org/query/uniprot/P39385 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418756 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418756 RefSeq WP_001037419 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001037419 SMR P39385 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39385 STRING 511145.b4336 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4336&targetmode=cogs UniProtKB YJIN_ECOLI http://www.uniprot.org/uniprot/YJIN_ECOLI UniProtKB-AC P39385 http://www.uniprot.org/uniprot/P39385 charge swissprot:YJIN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJIN_ECOLI eggNOG COG2733 http://eggnogapi.embl.de/nog_data/html/tree/COG2733 eggNOG ENOG4106BRA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106BRA epestfind swissprot:YJIN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJIN_ECOLI garnier swissprot:YJIN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJIN_ECOLI helixturnhelix swissprot:YJIN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJIN_ECOLI hmoment swissprot:YJIN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJIN_ECOLI iep swissprot:YJIN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJIN_ECOLI inforesidue swissprot:YJIN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJIN_ECOLI octanol swissprot:YJIN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJIN_ECOLI pepcoil swissprot:YJIN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJIN_ECOLI pepdigest swissprot:YJIN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJIN_ECOLI pepinfo swissprot:YJIN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJIN_ECOLI pepnet swissprot:YJIN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJIN_ECOLI pepstats swissprot:YJIN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJIN_ECOLI pepwheel swissprot:YJIN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJIN_ECOLI pepwindow swissprot:YJIN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJIN_ECOLI sigcleave swissprot:YJIN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJIN_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES pH dependence Optimum pH is 8.0.; # BioGrid 4261754 77 # CATALYTIC ACTIVITY MTOX_ECOLI N-methyl-L-tryptophan + H(2)O + O(2) = L- tryptophan + formaldehyde + H(2)O(2). # COFACTOR Name=FAD; Xref=ChEBI:CHEBI 57692; Note=Binds 1 FAD per subunit.; # ENZYME REGULATION MTOX_ECOLI Aromatic carboxylates are competitive inhibitors. # EcoGene EG12669 solA # FUNCTION MTOX_ECOLI Catalyzes the oxidative demethylation of N-methyl-L- tryptophan. Can also use other N-methyl amino acids, including sarcosine, which, however, is a poor substrate. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0050131 N-methyl-L-amino-acid oxidase activity; IDA:EcoCyc. # GO_function GO:0050660 flavin adenine dinucleotide binding; IDA:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # Gene3D 3.50.50.60 -; 3. # HAMAP MF_00515 MTOX # IntAct P40874 9 # InterPro IPR006076 FAD-dep_OxRdtase # InterPro IPR023493 Me_Trp_Oxase_MTOX # InterPro IPR023753 FAD/NAD-binding_dom # KEGG_Brite ko01000 Enzymes # MASS SPECTROMETRY Mass=41684; Method=Electrospray; Range=1-372; Evidence={ECO:0000269|PubMed 10220347}; # Organism MTOX_ECOLI Escherichia coli (strain K12) # PATRIC 32117357 VBIEscCol129921_1101 # PDB 2UZZ X-ray; 3.20 A; A/B/C/D=1-372 # PIR JC5371 JC5371 # Pfam PF01266 DAO # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MTOX_ECOLI N-methyl-L-tryptophan oxidase # RefSeq NP_415577 NC_000913.3 # RefSeq WP_000872833 NZ_LN832404.1 # SIMILARITY Belongs to the MSOX/MTOX family. MTOX subfamily. {ECO 0000305}. # SUBUNIT Monomer. {ECO 0000250}. # SUPFAM SSF51905 SSF51905; 2 # eggNOG COG0665 LUCA # eggNOG ENOG4105F76 Bacteria BLAST swissprot:MTOX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MTOX_ECOLI BioCyc ECOL316407:JW1046-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1046-MONOMER BioCyc EcoCyc:SARCOX-MONOMER http://biocyc.org/getid?id=EcoCyc:SARCOX-MONOMER BioCyc MetaCyc:SARCOX-MONOMER http://biocyc.org/getid?id=MetaCyc:SARCOX-MONOMER COG COG0665 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0665 DOI 10.1002/prot.21898 http://dx.doi.org/10.1002/prot.21898 DOI 10.1016/S0378-1119(96)00500-8 http://dx.doi.org/10.1016/S0378-1119(96)00500-8 DOI 10.1021/bi0024411 http://dx.doi.org/10.1021/bi0024411 DOI 10.1021/bi002442t http://dx.doi.org/10.1021/bi002442t DOI 10.1021/bi982955o http://dx.doi.org/10.1021/bi982955o DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.5.3.- http://www.genome.jp/dbget-bin/www_bget?EC:1.5.3.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D31709 http://www.ebi.ac.uk/ena/data/view/D31709 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.5.3.- http://enzyme.expasy.org/EC/1.5.3.- EchoBASE EB2535 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2535 EcoGene EG12669 http://www.ecogene.org/geneInfo.php?eg_id=EG12669 EnsemblBacteria AAC74143 http://www.ensemblgenomes.org/id/AAC74143 EnsemblBacteria AAC74143 http://www.ensemblgenomes.org/id/AAC74143 EnsemblBacteria BAA35856 http://www.ensemblgenomes.org/id/BAA35856 EnsemblBacteria BAA35856 http://www.ensemblgenomes.org/id/BAA35856 EnsemblBacteria BAA35856 http://www.ensemblgenomes.org/id/BAA35856 EnsemblBacteria b1059 http://www.ensemblgenomes.org/id/b1059 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0050131 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050131 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 GeneID 944983 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944983 HAMAP MF_00515 http://hamap.expasy.org/unirule/MF_00515 HOGENOM HOG000236098 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000236098&db=HOGENOM6 InParanoid P40874 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P40874 IntAct P40874 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P40874* IntEnz 1.5.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.5.3 InterPro IPR006076 http://www.ebi.ac.uk/interpro/entry/IPR006076 InterPro IPR023493 http://www.ebi.ac.uk/interpro/entry/IPR023493 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1046 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1046 KEGG_Gene eco:b1059 http://www.genome.jp/dbget-bin/www_bget?eco:b1059 KEGG_Orthology KO:K02846 http://www.genome.jp/dbget-bin/www_bget?KO:K02846 OMA DGDYQAK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DGDYQAK PDB 2UZZ http://www.ebi.ac.uk/pdbe-srv/view/entry/2UZZ PDBsum 2UZZ http://www.ebi.ac.uk/pdbsum/2UZZ PSORT swissprot:MTOX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MTOX_ECOLI PSORT-B swissprot:MTOX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MTOX_ECOLI PSORT2 swissprot:MTOX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MTOX_ECOLI Pfam PF01266 http://pfam.xfam.org/family/PF01266 Phobius swissprot:MTOX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MTOX_ECOLI PhylomeDB P40874 http://phylomedb.org/?seqid=P40874 ProteinModelPortal P40874 http://www.proteinmodelportal.org/query/uniprot/P40874 PubMed 10220347 http://www.ncbi.nlm.nih.gov/pubmed/10220347 PubMed 11170472 http://www.ncbi.nlm.nih.gov/pubmed/11170472 PubMed 11170473 http://www.ncbi.nlm.nih.gov/pubmed/11170473 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18186483 http://www.ncbi.nlm.nih.gov/pubmed/18186483 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 8973328 http://www.ncbi.nlm.nih.gov/pubmed/8973328 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415577 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415577 RefSeq WP_000872833 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000872833 SMR P40874 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P40874 STRING 511145.b1059 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1059&targetmode=cogs STRING COG0665 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0665&targetmode=cogs SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 UniProtKB MTOX_ECOLI http://www.uniprot.org/uniprot/MTOX_ECOLI UniProtKB-AC P40874 http://www.uniprot.org/uniprot/P40874 charge swissprot:MTOX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MTOX_ECOLI eggNOG COG0665 http://eggnogapi.embl.de/nog_data/html/tree/COG0665 eggNOG ENOG4105F76 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F76 epestfind swissprot:MTOX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MTOX_ECOLI garnier swissprot:MTOX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MTOX_ECOLI helixturnhelix swissprot:MTOX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MTOX_ECOLI hmoment swissprot:MTOX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MTOX_ECOLI iep swissprot:MTOX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MTOX_ECOLI inforesidue swissprot:MTOX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MTOX_ECOLI octanol swissprot:MTOX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MTOX_ECOLI pepcoil swissprot:MTOX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MTOX_ECOLI pepdigest swissprot:MTOX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MTOX_ECOLI pepinfo swissprot:MTOX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MTOX_ECOLI pepnet swissprot:MTOX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MTOX_ECOLI pepstats swissprot:MTOX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MTOX_ECOLI pepwheel swissprot:MTOX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MTOX_ECOLI pepwindow swissprot:MTOX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MTOX_ECOLI sigcleave swissprot:MTOX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MTOX_ECOLI ## Database ID URL or Descriptions # AltName RIML_ECOLI Acetylating enzyme for N-terminal of ribosomal protein L7/L12 # BioGrid 4260179 34 # CATALYTIC ACTIVITY RIML_ECOLI Acetyl-CoA + ribosomal-protein L-serine = CoA + ribosomal-protein N-acetyl-L-serine. # EcoGene EG10853 rimL # FUNCTION RIML_ECOLI This enzyme acetylates the N-terminal serine of ribosomal protein L7/L12. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_function GO:0004596 peptide alpha-N-acetyltransferase activity; IDA:EcoCyc. # GO_function GO:0008080 N-acetyltransferase activity; IDA:EcoliWiki. # GO_function GO:0008999 ribosomal-protein-alanine N-acetyltransferase activity; IDA:EcoliWiki. # GO_function GO:1990189 peptide-serine-N-acetyltransferase activity; IDA:EcoCyc. # GO_process GO:0006464 cellular protein modification process; IDA:EcoliWiki. # GO_process GO:0006474 N-terminal protein amino acid acetylation; IDA:EcoliWiki. # GO_process GO:0017198 N-terminal peptidyl-serine acetylation; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0006464 cellular protein modification process # Gene3D 3.40.630.30 -; 1. # IntAct P13857 2 # InterPro IPR000182 GNAT_dom # InterPro IPR016181 Acyl_CoA_acyltransferase # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # Organism RIML_ECOLI Escherichia coli (strain K12) # PATRIC 32118138 VBIEscCol129921_1489 # PIR S04776 XXECPL # PROSITE PS51186 GNAT # Pfam PF13302 Acetyltransf_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RIML_ECOLI Ribosomal-protein-serine acetyltransferase # RefSeq NP_415944 NC_000913.3 # RefSeq WP_000140873 NZ_LN832404.1 # SIMILARITY Belongs to the acetyltransferase family. RimL subfamily. {ECO 0000305}. # SIMILARITY Contains 1 N-acetyltransferase domain. {ECO:0000255|PROSITE-ProRule PRU00532}. # SUBCELLULAR LOCATION RIML_ECOLI Cytoplasm. # SUPFAM SSF55729 SSF55729 # eggNOG COG1670 LUCA # eggNOG ENOG4108Z9I Bacteria BLAST swissprot:RIML_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RIML_ECOLI BioCyc ECOL316407:JW1423-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1423-MONOMER BioCyc EcoCyc:EG10853-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10853-MONOMER COG COG1670 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1670 DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1007/BF02464895 http://dx.doi.org/10.1007/BF02464895 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X15860 http://www.ebi.ac.uk/ena/data/view/X15860 ENZYME 2.3.1.- http://enzyme.expasy.org/EC/2.3.1.- EchoBASE EB0846 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0846 EcoGene EG10853 http://www.ecogene.org/geneInfo.php?eg_id=EG10853 EnsemblBacteria AAC74509 http://www.ensemblgenomes.org/id/AAC74509 EnsemblBacteria AAC74509 http://www.ensemblgenomes.org/id/AAC74509 EnsemblBacteria BAA15048 http://www.ensemblgenomes.org/id/BAA15048 EnsemblBacteria BAA15048 http://www.ensemblgenomes.org/id/BAA15048 EnsemblBacteria BAA15048 http://www.ensemblgenomes.org/id/BAA15048 EnsemblBacteria b1427 http://www.ensemblgenomes.org/id/b1427 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004596 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004596 GO_function GO:0008080 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008080 GO_function GO:0008999 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008999 GO_function GO:1990189 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990189 GO_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GO_process GO:0006474 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006474 GO_process GO:0017198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017198 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 Gene3D 3.40.630.30 http://www.cathdb.info/version/latest/superfamily/3.40.630.30 GeneID 945998 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945998 HOGENOM HOG000120553 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120553&db=HOGENOM6 InParanoid P13857 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P13857 IntAct P13857 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P13857* IntEnz 2.3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1 InterPro IPR000182 http://www.ebi.ac.uk/interpro/entry/IPR000182 InterPro IPR016181 http://www.ebi.ac.uk/interpro/entry/IPR016181 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW1423 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1423 KEGG_Gene eco:b1427 http://www.genome.jp/dbget-bin/www_bget?eco:b1427 KEGG_Orthology KO:K03817 http://www.genome.jp/dbget-bin/www_bget?KO:K03817 OMA AYIGYWI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AYIGYWI PROSITE PS51186 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51186 PSORT swissprot:RIML_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RIML_ECOLI PSORT-B swissprot:RIML_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RIML_ECOLI PSORT2 swissprot:RIML_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RIML_ECOLI Pfam PF13302 http://pfam.xfam.org/family/PF13302 Phobius swissprot:RIML_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RIML_ECOLI PhylomeDB P13857 http://phylomedb.org/?seqid=P13857 ProteinModelPortal P13857 http://www.proteinmodelportal.org/query/uniprot/P13857 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2671655 http://www.ncbi.nlm.nih.gov/pubmed/2671655 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_415944 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415944 RefSeq WP_000140873 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000140873 SMR P13857 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P13857 STRING 511145.b1427 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1427&targetmode=cogs STRING COG1670 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1670&targetmode=cogs SUPFAM SSF55729 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55729 SWISS-2DPAGE P13857 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P13857 UniProtKB RIML_ECOLI http://www.uniprot.org/uniprot/RIML_ECOLI UniProtKB-AC P13857 http://www.uniprot.org/uniprot/P13857 charge swissprot:RIML_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RIML_ECOLI eggNOG COG1670 http://eggnogapi.embl.de/nog_data/html/tree/COG1670 eggNOG ENOG4108Z9I http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Z9I epestfind swissprot:RIML_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RIML_ECOLI garnier swissprot:RIML_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RIML_ECOLI helixturnhelix swissprot:RIML_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RIML_ECOLI hmoment swissprot:RIML_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RIML_ECOLI iep swissprot:RIML_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RIML_ECOLI inforesidue swissprot:RIML_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RIML_ECOLI octanol swissprot:RIML_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RIML_ECOLI pepcoil swissprot:RIML_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RIML_ECOLI pepdigest swissprot:RIML_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RIML_ECOLI pepinfo swissprot:RIML_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RIML_ECOLI pepnet swissprot:RIML_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RIML_ECOLI pepstats swissprot:RIML_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RIML_ECOLI pepwheel swissprot:RIML_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RIML_ECOLI pepwindow swissprot:RIML_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RIML_ECOLI sigcleave swissprot:RIML_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RIML_ECOLI ## Database ID URL or Descriptions # AltName YQJH_ECOLI Ferric siderophore reductase # BIOPHYSICOCHEMICAL PROPERTIES YQJH_ECOLI Kinetic parameters KM=33 uM for ferric ions (anaerobically at pH 7.5) {ECO 0000269|PubMed 21097627}; KM=43 uM for NADPH (anaerobically at pH 7.5) {ECO 0000269|PubMed 21097627}; # BioGrid 4259593 17 # CATALYTIC ACTIVITY 2 Fe(II)-siderophore + NADP(+) + H(+) = 2 Fe(III)-siderophore + NADPH. {ECO:0000269|PubMed 21097627}. # DISRUPTION PHENOTYPE Inactivation leads to ferrous iron chelator resistance as the wild-type. {ECO:0000269|PubMed 21097627}. # EcoGene EG12953 yqjH # FUNCTION YQJH_ECOLI Plays a role in iron homeostasis under excess nickel conditions. {ECO 0000269|PubMed 21097627}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0050660 flavin adenine dinucleotide binding; IDA:EcoCyc. # GO_function GO:0052851 ferric-chelate reductase (NADPH) activity; IDA:UniProtKB. # GO_function GO:0071949 FAD binding; IDA:EcoCyc. # GO_process GO:0033212 iron assimilation; IMP:EcoCyc. # GO_process GO:0071289 cellular response to nickel ion; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0042592 homeostatic process # INDUCTION Repressed by YqjI and Fur. YqjI is required for nickel- dependent regulation of yqjH, while Fur is required for iron- and cobalt-dependent regulation of yqjH. {ECO:0000269|PubMed 21097627}. # IntAct Q46871 3 # InterPro IPR007037 SIP # InterPro IPR013113 FAD-bd_9_SIP # InterPro IPR017927 Fd_Rdtase_FAD-bd # InterPro IPR017938 Riboflavin_synthase-like_b-brl # KEGG_Brite ko01000 Enzymes # Organism YQJH_ECOLI Escherichia coli (strain K12) # PATRIC 32121556 VBIEscCol129921_3164 # PIR C65095 C65095 # PROSITE PS51384 FAD_FR # Pfam PF04954 SIP # Pfam PF08021 FAD_binding_9 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQJH_ECOLI NADPH-dependent ferric-chelate reductase # RefSeq NP_417541 NC_000913.3 # RefSeq WP_001066494 NZ_LN832404.1 # SIMILARITY Belongs to the SIP oxidoreductase family. {ECO 0000305}. # SIMILARITY Contains 1 FAD-binding FR-type domain. {ECO:0000255|PROSITE-ProRule PRU00716}. # SUBCELLULAR LOCATION YQJH_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF63380 SSF63380 # eggNOG COG2375 LUCA # eggNOG ENOG4105Q26 Bacteria BLAST swissprot:YQJH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQJH_ECOLI BioCyc ECOL316407:JW3041-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3041-MONOMER BioCyc EcoCyc:G7593-MONOMER http://biocyc.org/getid?id=EcoCyc:G7593-MONOMER BioCyc MetaCyc:G7593-MONOMER http://biocyc.org/getid?id=MetaCyc:G7593-MONOMER COG COG2375 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2375 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1107/S174430910802352X http://dx.doi.org/10.1107/S174430910802352X DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01062-10 http://dx.doi.org/10.1128/JB.01062-10 EC_number EC:1.16.1.9 http://www.genome.jp/dbget-bin/www_bget?EC:1.16.1.9 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28379 http://www.ebi.ac.uk/ena/data/view/U28379 ENZYME 1.16.1.9 http://enzyme.expasy.org/EC/1.16.1.9 EchoBASE EB2787 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2787 EcoGene EG12953 http://www.ecogene.org/geneInfo.php?eg_id=EG12953 EnsemblBacteria AAC76105 http://www.ensemblgenomes.org/id/AAC76105 EnsemblBacteria AAC76105 http://www.ensemblgenomes.org/id/AAC76105 EnsemblBacteria BAE77120 http://www.ensemblgenomes.org/id/BAE77120 EnsemblBacteria BAE77120 http://www.ensemblgenomes.org/id/BAE77120 EnsemblBacteria BAE77120 http://www.ensemblgenomes.org/id/BAE77120 EnsemblBacteria b3070 http://www.ensemblgenomes.org/id/b3070 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_function GO:0052851 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052851 GO_function GO:0071949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071949 GO_process GO:0033212 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033212 GO_process GO:0071289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071289 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GeneID 947582 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947582 HOGENOM HOG000221089 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000221089&db=HOGENOM6 InParanoid Q46871 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46871 IntAct Q46871 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46871* IntEnz 1.16.1.9 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.16.1.9 InterPro IPR007037 http://www.ebi.ac.uk/interpro/entry/IPR007037 InterPro IPR013113 http://www.ebi.ac.uk/interpro/entry/IPR013113 InterPro IPR017927 http://www.ebi.ac.uk/interpro/entry/IPR017927 InterPro IPR017938 http://www.ebi.ac.uk/interpro/entry/IPR017938 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3041 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3041 KEGG_Gene eco:b3070 http://www.genome.jp/dbget-bin/www_bget?eco:b3070 KEGG_Orthology KO:K07229 http://www.genome.jp/dbget-bin/www_bget?KO:K07229 OMA VVPDIFD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VVPDIFD PROSITE PS51384 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51384 PSORT swissprot:YQJH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQJH_ECOLI PSORT-B swissprot:YQJH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQJH_ECOLI PSORT2 swissprot:YQJH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQJH_ECOLI Pfam PF04954 http://pfam.xfam.org/family/PF04954 Pfam PF08021 http://pfam.xfam.org/family/PF08021 Phobius swissprot:YQJH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQJH_ECOLI PhylomeDB Q46871 http://phylomedb.org/?seqid=Q46871 ProteinModelPortal Q46871 http://www.proteinmodelportal.org/query/uniprot/Q46871 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18765906 http://www.ncbi.nlm.nih.gov/pubmed/18765906 PubMed 21097627 http://www.ncbi.nlm.nih.gov/pubmed/21097627 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417541 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417541 RefSeq WP_001066494 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001066494 SMR Q46871 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46871 STRING 511145.b3070 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3070&targetmode=cogs STRING COG2375 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2375&targetmode=cogs SUPFAM SSF63380 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63380 UniProtKB YQJH_ECOLI http://www.uniprot.org/uniprot/YQJH_ECOLI UniProtKB-AC Q46871 http://www.uniprot.org/uniprot/Q46871 charge swissprot:YQJH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQJH_ECOLI eggNOG COG2375 http://eggnogapi.embl.de/nog_data/html/tree/COG2375 eggNOG ENOG4105Q26 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105Q26 epestfind swissprot:YQJH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQJH_ECOLI garnier swissprot:YQJH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQJH_ECOLI helixturnhelix swissprot:YQJH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQJH_ECOLI hmoment swissprot:YQJH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQJH_ECOLI iep swissprot:YQJH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQJH_ECOLI inforesidue swissprot:YQJH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQJH_ECOLI octanol swissprot:YQJH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQJH_ECOLI pepcoil swissprot:YQJH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQJH_ECOLI pepdigest swissprot:YQJH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQJH_ECOLI pepinfo swissprot:YQJH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQJH_ECOLI pepnet swissprot:YQJH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQJH_ECOLI pepstats swissprot:YQJH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQJH_ECOLI pepwheel swissprot:YQJH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQJH_ECOLI pepwindow swissprot:YQJH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQJH_ECOLI sigcleave swissprot:YQJH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQJH_ECOLI ## Database ID URL or Descriptions # BioGrid 4260203 9 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG14360 yneL # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_function GO:0043565 sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # InterPro IPR018060 HTH_AraC # Organism YNEL_ECOLI Escherichia coli (strain K12) # PIR E64904 E64904 # PROSITE PS01124 HTH_ARAC_FAMILY_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNEL_ECOLI Putative HTH-type transcriptional regulator YneL # RefSeq WP_001310818 NZ_LN832404.1 # SIMILARITY Contains 1 HTH araC/xylS-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00593}. BLAST swissprot:YNEL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNEL_ECOLI BioCyc ECOL316407:JW5244-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5244-MONOMER BioCyc EcoCyc:G6796-MONOMER http://biocyc.org/getid?id=EcoCyc:G6796-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14360 http://www.ecogene.org/geneInfo.php?eg_id=EG14360 EnsemblBacteria BAE76455 http://www.ensemblgenomes.org/id/BAE76455 EnsemblBacteria BAE76455 http://www.ensemblgenomes.org/id/BAE76455 EnsemblBacteria BAE76455 http://www.ensemblgenomes.org/id/BAE76455 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 HOGENOM HOG000145020 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000145020&db=HOGENOM6 InterPro IPR018060 http://www.ebi.ac.uk/interpro/entry/IPR018060 KEGG_Gene ecj:JW5244 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5244 PROSITE PS01124 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01124 PSORT swissprot:YNEL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNEL_ECOLI PSORT-B swissprot:YNEL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNEL_ECOLI PSORT2 swissprot:YNEL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNEL_ECOLI Phobius swissprot:YNEL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNEL_ECOLI ProteinModelPortal P76138 http://www.proteinmodelportal.org/query/uniprot/P76138 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001310818 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001310818 STRING 316407.85674996 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85674996&targetmode=cogs UniProtKB YNEL_ECOLI http://www.uniprot.org/uniprot/YNEL_ECOLI UniProtKB-AC P76138 http://www.uniprot.org/uniprot/P76138 charge swissprot:YNEL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNEL_ECOLI epestfind swissprot:YNEL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNEL_ECOLI garnier swissprot:YNEL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNEL_ECOLI helixturnhelix swissprot:YNEL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNEL_ECOLI hmoment swissprot:YNEL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNEL_ECOLI iep swissprot:YNEL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNEL_ECOLI inforesidue swissprot:YNEL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNEL_ECOLI octanol swissprot:YNEL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNEL_ECOLI pepcoil swissprot:YNEL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNEL_ECOLI pepdigest swissprot:YNEL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNEL_ECOLI pepinfo swissprot:YNEL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNEL_ECOLI pepnet swissprot:YNEL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNEL_ECOLI pepstats swissprot:YNEL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNEL_ECOLI pepwheel swissprot:YNEL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNEL_ECOLI pepwindow swissprot:YNEL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNEL_ECOLI sigcleave swissprot:YNEL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNEL_ECOLI ## Database ID URL or Descriptions # AltName MCRA_ECOLI EcoKMcrA # BioGrid 4262863 146 # EcoGene EG10573 mcrA # FUNCTION MCRA_ECOLI Restriction of 5-methyl and 5-hydroxymethylcytosines at the specific DNA sequence C(me)CGG. # GO_function GO:0004519 endonuclease activity; IEA:UniProtKB-KW. # GO_function GO:0008327 methyl-CpG binding; IDA:EcoliWiki. # GO_process GO:0009307 DNA restriction-modification system; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004518 nuclease activity # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # IntAct P24200 3 # InterPro IPR002711 HNH # InterPro IPR003615 HNH_nuc # KEGG_Brite ko01000 Enzymes # Organism MCRA_ECOLI Escherichia coli (strain K12) # PATRIC 32117555 VBIEscCol129921_1200 # PIR A41424 A41424 # Pfam PF01844 HNH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # REBASE 2832 EcoKMcrA # RecName MCRA_ECOLI 5-methylcytosine-specific restriction enzyme A # RefSeq NP_415677 NC_000913.3 # RefSeq WP_000557907 NZ_CP010440.1 # SIMILARITY Contains 1 HNH domain. {ECO 0000305}. # SMART SM00507 HNHc # eggNOG COG1403 LUCA # eggNOG ENOG4108R4U Bacteria BLAST swissprot:MCRA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MCRA_ECOLI BioCyc ECOL316407:JW1145-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1145-MONOMER BioCyc EcoCyc:EG10573-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10573-MONOMER BioCyc MetaCyc:EG10573-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10573-MONOMER COG COG1403 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1403 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.21.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.21.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M76667 http://www.ebi.ac.uk/ena/data/view/M76667 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL Z19104 http://www.ebi.ac.uk/ena/data/view/Z19104 ENZYME 3.1.21.- http://enzyme.expasy.org/EC/3.1.21.- EchoBASE EB0568 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0568 EcoGene EG10573 http://www.ecogene.org/geneInfo.php?eg_id=EG10573 EnsemblBacteria AAC74243 http://www.ensemblgenomes.org/id/AAC74243 EnsemblBacteria AAC74243 http://www.ensemblgenomes.org/id/AAC74243 EnsemblBacteria BAA35995 http://www.ensemblgenomes.org/id/BAA35995 EnsemblBacteria BAA35995 http://www.ensemblgenomes.org/id/BAA35995 EnsemblBacteria BAA35995 http://www.ensemblgenomes.org/id/BAA35995 EnsemblBacteria b1159 http://www.ensemblgenomes.org/id/b1159 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004519 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004519 GO_function GO:0008327 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008327 GO_process GO:0009307 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009307 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 945727 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945727 IntAct P24200 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P24200* IntEnz 3.1.21 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.21 InterPro IPR002711 http://www.ebi.ac.uk/interpro/entry/IPR002711 InterPro IPR003615 http://www.ebi.ac.uk/interpro/entry/IPR003615 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1145 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1145 KEGG_Gene eco:b1159 http://www.genome.jp/dbget-bin/www_bget?eco:b1159 KEGG_Orthology KO:K07451 http://www.genome.jp/dbget-bin/www_bget?KO:K07451 PSORT swissprot:MCRA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MCRA_ECOLI PSORT-B swissprot:MCRA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MCRA_ECOLI PSORT2 swissprot:MCRA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MCRA_ECOLI Pfam PF01844 http://pfam.xfam.org/family/PF01844 Phobius swissprot:MCRA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MCRA_ECOLI ProteinModelPortal P24200 http://www.proteinmodelportal.org/query/uniprot/P24200 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1938927 http://www.ncbi.nlm.nih.gov/pubmed/1938927 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 REBASE 2832 http://rebase.neb.com/rebase/enz/2832.html RefSeq NP_415677 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415677 RefSeq WP_000557907 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000557907 SMART SM00507 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00507 STRING 511145.b1159 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1159&targetmode=cogs STRING COG1403 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1403&targetmode=cogs UniProtKB MCRA_ECOLI http://www.uniprot.org/uniprot/MCRA_ECOLI UniProtKB-AC P24200 http://www.uniprot.org/uniprot/P24200 charge swissprot:MCRA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MCRA_ECOLI eggNOG COG1403 http://eggnogapi.embl.de/nog_data/html/tree/COG1403 eggNOG ENOG4108R4U http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108R4U epestfind swissprot:MCRA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MCRA_ECOLI garnier swissprot:MCRA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MCRA_ECOLI helixturnhelix swissprot:MCRA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MCRA_ECOLI hmoment swissprot:MCRA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MCRA_ECOLI iep swissprot:MCRA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MCRA_ECOLI inforesidue swissprot:MCRA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MCRA_ECOLI octanol swissprot:MCRA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MCRA_ECOLI pepcoil swissprot:MCRA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MCRA_ECOLI pepdigest swissprot:MCRA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MCRA_ECOLI pepinfo swissprot:MCRA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MCRA_ECOLI pepnet swissprot:MCRA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MCRA_ECOLI pepstats swissprot:MCRA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MCRA_ECOLI pepwheel swissprot:MCRA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MCRA_ECOLI pepwindow swissprot:MCRA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MCRA_ECOLI sigcleave swissprot:MCRA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MCRA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262983 8 # DISRUPTION PHENOTYPE Mutation confers sensitivity to SDS-EDTA and leads to accumulation of phospholipid in the outer leaflet of the outer membrane. {ECO:0000269|PubMed 19383799}. # EcoGene EG12798 mlaC # FUNCTION MLAC_ECOLI Actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. May transfer phospholipid across the periplasmic space and deliver it to the MlaFEDB complex at the inner membrane. {ECO 0000269|PubMed 19383799}. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_function GO:0005543 phospholipid binding; IMP:EcoCyc. # GO_process GO:0015914 phospholipid transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0008289 lipid binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # Gene3D 1.10.10.640 -; 2. # Gene3D 3.10.450.50 -; 2. # IntAct P0ADV7 2 # InterPro IPR008869 MlaC/ttg2D # InterPro IPR023094 Tol_tolerance_alpha # InterPro IPR032710 NTF2-like_dom # Organism MLAC_ECOLI Escherichia coli (strain K12) # PATRIC 32121804 VBIEscCol129921_3286 # PIR B65110 B65110 # PIRSF PIRSF004649 MlaC # Pfam PF05494 MlaC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Probable phospholipid-binding protein MlaC {ECO 0000305} # RefSeq NP_417659 NC_000913.3 # RefSeq WP_000476487 NZ_LN832404.1 # SIMILARITY Belongs to the MlaC/ttg2D family. {ECO 0000305}. # SUBCELLULAR LOCATION MLAC_ECOLI Periplasm {ECO 0000305|PubMed 19383799}. # TCDB 3.A.1.27 the atp-binding cassette (abc) superfamily # eggNOG COG2854 LUCA # eggNOG ENOG4105E3I Bacteria BLAST swissprot:MLAC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MLAC_ECOLI BioCyc ECOL316407:JW3159-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3159-MONOMER BioCyc EcoCyc:G7659-MONOMER http://biocyc.org/getid?id=EcoCyc:G7659-MONOMER COG COG2854 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2854 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0903229106 http://dx.doi.org/10.1073/pnas.0903229106 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2650 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2650 EcoGene EG12798 http://www.ecogene.org/geneInfo.php?eg_id=EG12798 EnsemblBacteria AAC76224 http://www.ensemblgenomes.org/id/AAC76224 EnsemblBacteria AAC76224 http://www.ensemblgenomes.org/id/AAC76224 EnsemblBacteria BAE77236 http://www.ensemblgenomes.org/id/BAE77236 EnsemblBacteria BAE77236 http://www.ensemblgenomes.org/id/BAE77236 EnsemblBacteria BAE77236 http://www.ensemblgenomes.org/id/BAE77236 EnsemblBacteria b3192 http://www.ensemblgenomes.org/id/b3192 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0005543 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005543 GO_process GO:0015914 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015914 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0008289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 1.10.10.640 http://www.cathdb.info/version/latest/superfamily/1.10.10.640 Gene3D 3.10.450.50 http://www.cathdb.info/version/latest/superfamily/3.10.450.50 GeneID 947710 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947710 HOGENOM HOG000284031 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000284031&db=HOGENOM6 InParanoid P0ADV7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADV7 IntAct P0ADV7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADV7* InterPro IPR008869 http://www.ebi.ac.uk/interpro/entry/IPR008869 InterPro IPR023094 http://www.ebi.ac.uk/interpro/entry/IPR023094 InterPro IPR032710 http://www.ebi.ac.uk/interpro/entry/IPR032710 KEGG_Gene ecj:JW3159 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3159 KEGG_Gene eco:b3192 http://www.genome.jp/dbget-bin/www_bget?eco:b3192 KEGG_Orthology KO:K07323 http://www.genome.jp/dbget-bin/www_bget?KO:K07323 OMA AEKTFTR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AEKTFTR PSORT swissprot:MLAC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MLAC_ECOLI PSORT-B swissprot:MLAC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MLAC_ECOLI PSORT2 swissprot:MLAC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MLAC_ECOLI Pfam PF05494 http://pfam.xfam.org/family/PF05494 Phobius swissprot:MLAC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MLAC_ECOLI PhylomeDB P0ADV7 http://phylomedb.org/?seqid=P0ADV7 ProteinModelPortal P0ADV7 http://www.proteinmodelportal.org/query/uniprot/P0ADV7 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19383799 http://www.ncbi.nlm.nih.gov/pubmed/19383799 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417659 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417659 RefSeq WP_000476487 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000476487 SMR P0ADV7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADV7 STRING 511145.b3192 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3192&targetmode=cogs STRING COG2854 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2854&targetmode=cogs SWISS-2DPAGE P0ADV7 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0ADV7 TCDB 3.A.1.27 http://www.tcdb.org/search/result.php?tc=3.A.1.27 UniProtKB MLAC_ECOLI http://www.uniprot.org/uniprot/MLAC_ECOLI UniProtKB-AC P0ADV7 http://www.uniprot.org/uniprot/P0ADV7 charge swissprot:MLAC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MLAC_ECOLI eggNOG COG2854 http://eggnogapi.embl.de/nog_data/html/tree/COG2854 eggNOG ENOG4105E3I http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E3I epestfind swissprot:MLAC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MLAC_ECOLI garnier swissprot:MLAC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MLAC_ECOLI helixturnhelix swissprot:MLAC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MLAC_ECOLI hmoment swissprot:MLAC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MLAC_ECOLI iep swissprot:MLAC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MLAC_ECOLI inforesidue swissprot:MLAC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MLAC_ECOLI octanol swissprot:MLAC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MLAC_ECOLI pepcoil swissprot:MLAC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MLAC_ECOLI pepdigest swissprot:MLAC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MLAC_ECOLI pepinfo swissprot:MLAC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MLAC_ECOLI pepnet swissprot:MLAC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MLAC_ECOLI pepstats swissprot:MLAC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MLAC_ECOLI pepwheel swissprot:MLAC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MLAC_ECOLI pepwindow swissprot:MLAC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MLAC_ECOLI sigcleave swissprot:MLAC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MLAC_ECOLI ## Database ID URL or Descriptions # BioGrid 4262790 11 # EcoGene EG12309 lasT # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003723 RNA binding; IBA:GO_Central. # GO_function GO:0052665 tRNA (uracil-2'-O-)-methyltransferase activity; IBA:GO_Central. # GO_function GO:0052666 tRNA (cytosine-2'-O-)-methyltransferase activity; IBA:GO_Central. # GO_process GO:0002128 tRNA nucleoside ribose methylation; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0006399 tRNA metabolic process # Gene3D 3.40.1280.10 -; 1. # IntAct P37005 9 # InterPro IPR001537 SpoU_MeTrfase # InterPro IPR004384 rRNA_MeTrfase_TrmH_1 # InterPro IPR029026 tRNA_m1G_MTases_N # InterPro IPR029028 Alpha/beta_knot_MTases # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # Organism LAST_ECOLI Escherichia coli (strain K12) # PATRIC 32124422 VBIEscCol129921_4551 # PIR S56627 S56627 # PIRSF PIRSF004808 LasT # Pfam PF00588 SpoU_methylase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LAST_ECOLI Uncharacterized tRNA/rRNA methyltransferase LasT # RefSeq NP_418820 NC_000913.3 # RefSeq WP_001223132 NZ_LN832404.1 # SIMILARITY Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. {ECO 0000305}. # SUPFAM SSF75217 SSF75217 # TIGRFAMs TIGR00050 rRNA_methyl_1 # eggNOG COG0565 LUCA # eggNOG ENOG4106FVC Bacteria BLAST swissprot:LAST_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LAST_ECOLI BioCyc ECOL316407:JW4366-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4366-MONOMER BioCyc EcoCyc:EG12309-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12309-MONOMER COG COG0565 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0565 DIP DIP-10084N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10084N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1111/j.1365-2958.1994.tb00374.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb00374.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L20873 http://www.ebi.ac.uk/ena/data/view/L20873 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 2.1.1.- http://enzyme.expasy.org/EC/2.1.1.- EchoBASE EB2215 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2215 EcoGene EG12309 http://www.ecogene.org/geneInfo.php?eg_id=EG12309 EnsemblBacteria AAC77356 http://www.ensemblgenomes.org/id/AAC77356 EnsemblBacteria AAC77356 http://www.ensemblgenomes.org/id/AAC77356 EnsemblBacteria BAE78392 http://www.ensemblgenomes.org/id/BAE78392 EnsemblBacteria BAE78392 http://www.ensemblgenomes.org/id/BAE78392 EnsemblBacteria BAE78392 http://www.ensemblgenomes.org/id/BAE78392 EnsemblBacteria b4403 http://www.ensemblgenomes.org/id/b4403 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0052665 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052665 GO_function GO:0052666 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052666 GO_process GO:0002128 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002128 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 Gene3D 3.40.1280.10 http://www.cathdb.info/version/latest/superfamily/3.40.1280.10 GeneID 948924 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948924 HOGENOM HOG000229629 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000229629&db=HOGENOM6 InParanoid P37005 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37005 IntAct P37005 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37005* IntEnz 2.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1 InterPro IPR001537 http://www.ebi.ac.uk/interpro/entry/IPR001537 InterPro IPR004384 http://www.ebi.ac.uk/interpro/entry/IPR004384 InterPro IPR029026 http://www.ebi.ac.uk/interpro/entry/IPR029026 InterPro IPR029028 http://www.ebi.ac.uk/interpro/entry/IPR029028 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW4366 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4366 KEGG_Gene eco:b4403 http://www.genome.jp/dbget-bin/www_bget?eco:b4403 KEGG_Orthology KO:K02533 http://www.genome.jp/dbget-bin/www_bget?KO:K02533 MINT MINT-1241070 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1241070 OMA DGLKNED http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DGLKNED PSORT swissprot:LAST_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LAST_ECOLI PSORT-B swissprot:LAST_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LAST_ECOLI PSORT2 swissprot:LAST_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LAST_ECOLI Pfam PF00588 http://pfam.xfam.org/family/PF00588 Phobius swissprot:LAST_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LAST_ECOLI PhylomeDB P37005 http://phylomedb.org/?seqid=P37005 ProteinModelPortal P37005 http://www.proteinmodelportal.org/query/uniprot/P37005 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8022271 http://www.ncbi.nlm.nih.gov/pubmed/8022271 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418820 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418820 RefSeq WP_001223132 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001223132 SMR P37005 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37005 STRING 511145.b4403 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4403&targetmode=cogs STRING COG0565 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0565&targetmode=cogs SUPFAM SSF75217 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF75217 TIGRFAMs TIGR00050 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00050 UniProtKB LAST_ECOLI http://www.uniprot.org/uniprot/LAST_ECOLI UniProtKB-AC P37005 http://www.uniprot.org/uniprot/P37005 charge swissprot:LAST_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LAST_ECOLI eggNOG COG0565 http://eggnogapi.embl.de/nog_data/html/tree/COG0565 eggNOG ENOG4106FVC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106FVC epestfind swissprot:LAST_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LAST_ECOLI garnier swissprot:LAST_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LAST_ECOLI helixturnhelix swissprot:LAST_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LAST_ECOLI hmoment swissprot:LAST_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LAST_ECOLI iep swissprot:LAST_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LAST_ECOLI inforesidue swissprot:LAST_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LAST_ECOLI octanol swissprot:LAST_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LAST_ECOLI pepcoil swissprot:LAST_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LAST_ECOLI pepdigest swissprot:LAST_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LAST_ECOLI pepinfo swissprot:LAST_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LAST_ECOLI pepnet swissprot:LAST_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LAST_ECOLI pepstats swissprot:LAST_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LAST_ECOLI pepwheel swissprot:LAST_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LAST_ECOLI pepwindow swissprot:LAST_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LAST_ECOLI sigcleave swissprot:LAST_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LAST_ECOLI ## Database ID URL or Descriptions # BioGrid 4261952 13 # EcoGene EG11741 envR # FUNCTION ENVR_ECOLI Potential regulator protein for the acrEF/envCD genes. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IMP:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0042493 response to drug; IMP:EcoCyc. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IMP:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.60 -; 1. # Gene3D 1.10.357.10 -; 1. # IntAct P0ACT2 7 # InterPro IPR001647 HTH_TetR # InterPro IPR009057 Homeodomain-like # InterPro IPR011075 Tet_transcr_reg_TetR-rel_C # InterPro IPR013572 Tscrpt_reg_MAATS_C # InterPro IPR015893 Tet_transcr_reg_TetR-like_C # InterPro IPR023772 DNA-bd_HTH_TetR-type_CS # Organism ENVR_ECOLI Escherichia coli (strain K12) # PATRIC 32121958 VBIEscCol129921_3363 # PIR B65119 B65119 # PRINTS PR00455 HTHTETR # PROSITE PS01081 HTH_TETR_1 # PROSITE PS50977 HTH_TETR_2 # Pfam PF00440 TetR_N # Pfam PF08361 TetR_C_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ENVR_ECOLI Probable acrEF/envCD operon repressor # RefSeq NP_417730 NC_000913.3 # RefSeq WP_001129518 NZ_LN832404.1 # SIMILARITY Contains 1 HTH tetR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00335}. # SUPFAM SSF46689 SSF46689 # SUPFAM SSF48498 SSF48498 # eggNOG ENOG4108XG4 Bacteria # eggNOG ENOG4111M3K LUCA BLAST swissprot:ENVR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ENVR_ECOLI BioCyc ECOL316407:JW3232-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3232-MONOMER BioCyc EcoCyc:EG11741-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11741-MONOMER DOI 10.1007/BF00290673 http://dx.doi.org/10.1007/BF00290673 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X57948 http://www.ebi.ac.uk/ena/data/view/X57948 EchoBASE EB1692 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1692 EcoGene EG11741 http://www.ecogene.org/geneInfo.php?eg_id=EG11741 EnsemblBacteria AAC76296 http://www.ensemblgenomes.org/id/AAC76296 EnsemblBacteria AAC76296 http://www.ensemblgenomes.org/id/AAC76296 EnsemblBacteria BAE77305 http://www.ensemblgenomes.org/id/BAE77305 EnsemblBacteria BAE77305 http://www.ensemblgenomes.org/id/BAE77305 EnsemblBacteria BAE77305 http://www.ensemblgenomes.org/id/BAE77305 EnsemblBacteria b3264 http://www.ensemblgenomes.org/id/b3264 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0042493 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 Gene3D 1.10.357.10 http://www.cathdb.info/version/latest/superfamily/1.10.357.10 GeneID 947704 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947704 HOGENOM HOG000260115 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260115&db=HOGENOM6 InParanoid P0ACT2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACT2 IntAct P0ACT2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACT2* InterPro IPR001647 http://www.ebi.ac.uk/interpro/entry/IPR001647 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR011075 http://www.ebi.ac.uk/interpro/entry/IPR011075 InterPro IPR013572 http://www.ebi.ac.uk/interpro/entry/IPR013572 InterPro IPR015893 http://www.ebi.ac.uk/interpro/entry/IPR015893 InterPro IPR023772 http://www.ebi.ac.uk/interpro/entry/IPR023772 KEGG_Gene ecj:JW3232 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3232 KEGG_Gene eco:b3264 http://www.genome.jp/dbget-bin/www_bget?eco:b3264 OMA PRQRALM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PRQRALM PRINTS PR00455 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00455 PROSITE PS01081 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01081 PROSITE PS50977 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50977 PSORT swissprot:ENVR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ENVR_ECOLI PSORT-B swissprot:ENVR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ENVR_ECOLI PSORT2 swissprot:ENVR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ENVR_ECOLI Pfam PF00440 http://pfam.xfam.org/family/PF00440 Pfam PF08361 http://pfam.xfam.org/family/PF08361 Phobius swissprot:ENVR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ENVR_ECOLI PhylomeDB P0ACT2 http://phylomedb.org/?seqid=P0ACT2 ProteinModelPortal P0ACT2 http://www.proteinmodelportal.org/query/uniprot/P0ACT2 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1720861 http://www.ncbi.nlm.nih.gov/pubmed/1720861 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417730 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417730 RefSeq WP_001129518 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001129518 SMR P0ACT2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACT2 STRING 511145.b3264 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3264&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF48498 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48498 UniProtKB ENVR_ECOLI http://www.uniprot.org/uniprot/ENVR_ECOLI UniProtKB-AC P0ACT2 http://www.uniprot.org/uniprot/P0ACT2 charge swissprot:ENVR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ENVR_ECOLI eggNOG ENOG4108XG4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108XG4 eggNOG ENOG4111M3K http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111M3K epestfind swissprot:ENVR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ENVR_ECOLI garnier swissprot:ENVR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ENVR_ECOLI helixturnhelix swissprot:ENVR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ENVR_ECOLI hmoment swissprot:ENVR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ENVR_ECOLI iep swissprot:ENVR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ENVR_ECOLI inforesidue swissprot:ENVR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ENVR_ECOLI octanol swissprot:ENVR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ENVR_ECOLI pepcoil swissprot:ENVR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ENVR_ECOLI pepdigest swissprot:ENVR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ENVR_ECOLI pepinfo swissprot:ENVR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ENVR_ECOLI pepnet swissprot:ENVR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ENVR_ECOLI pepstats swissprot:ENVR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ENVR_ECOLI pepwheel swissprot:ENVR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ENVR_ECOLI pepwindow swissprot:ENVR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ENVR_ECOLI sigcleave swissprot:ENVR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ENVR_ECOLI ## Database ID URL or Descriptions # FUNCTION TRAT1_ECOLI Responsible for preventing unproductive conjugation between bacteria carrying like plasmids. # GO_component GO:0009279 cell outer membrane; IEA:UniProtKB-SubCell. # GO_process GO:0000746 conjugation; IEA:UniProtKB-KW. # GO_process GO:0046999 regulation of conjugation; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0008150 biological_process # InterPro IPR008874 TraT_complement-R # Organism TRAT1_ECOLI Escherichia coli (strain K12) # PIR S01757 S01757 # PIRSF PIRSF002859 Lipo_traT # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF05818 TraT # RecName TRAT1_ECOLI TraT complement resistance protein # RefSeq NP_061480 NC_002483.1 # RefSeq WP_000978374 NC_002483.1 # SIMILARITY Belongs to the TraT lipoprotein family. {ECO 0000305}. # SUBCELLULAR LOCATION TRAT1_ECOLI Cell outer membrane; Lipid-anchor. BLAST swissprot:TRAT1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRAT1_ECOLI DOI 10.1016/0022-2836(87)90452-9 http://dx.doi.org/10.1016/0022-2836(87)90452-9 DOI 10.1016/0378-1119(89)90179-0 http://dx.doi.org/10.1016/0378-1119(89)90179-0 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL M29254 http://www.ebi.ac.uk/ena/data/view/M29254 EMBL U01159 http://www.ebi.ac.uk/ena/data/view/U01159 EMBL X06915 http://www.ebi.ac.uk/ena/data/view/X06915 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_process GO:0000746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000746 GO_process GO:0046999 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046999 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 1263516 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263516 InterPro IPR008874 http://www.ebi.ac.uk/interpro/entry/IPR008874 OMA DVQTKMS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DVQTKMS PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:TRAT1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRAT1_ECOLI PSORT-B swissprot:TRAT1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRAT1_ECOLI PSORT2 swissprot:TRAT1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRAT1_ECOLI Pfam PF05818 http://pfam.xfam.org/family/PF05818 Phobius swissprot:TRAT1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRAT1_ECOLI PhylomeDB P13979 http://phylomedb.org/?seqid=P13979 ProteinModelPortal P13979 http://www.proteinmodelportal.org/query/uniprot/P13979 PubMed 2680768 http://www.ncbi.nlm.nih.gov/pubmed/2680768 PubMed 3323526 http://www.ncbi.nlm.nih.gov/pubmed/3323526 PubMed 7915817 http://www.ncbi.nlm.nih.gov/pubmed/7915817 RefSeq NP_061480 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061480 RefSeq WP_000978374 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000978374 UniProtKB TRAT1_ECOLI http://www.uniprot.org/uniprot/TRAT1_ECOLI UniProtKB-AC P13979 http://www.uniprot.org/uniprot/P13979 charge swissprot:TRAT1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRAT1_ECOLI epestfind swissprot:TRAT1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRAT1_ECOLI garnier swissprot:TRAT1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRAT1_ECOLI helixturnhelix swissprot:TRAT1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRAT1_ECOLI hmoment swissprot:TRAT1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRAT1_ECOLI iep swissprot:TRAT1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRAT1_ECOLI inforesidue swissprot:TRAT1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRAT1_ECOLI octanol swissprot:TRAT1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRAT1_ECOLI pepcoil swissprot:TRAT1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRAT1_ECOLI pepdigest swissprot:TRAT1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRAT1_ECOLI pepinfo swissprot:TRAT1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRAT1_ECOLI pepnet swissprot:TRAT1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRAT1_ECOLI pepstats swissprot:TRAT1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRAT1_ECOLI pepwheel swissprot:TRAT1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRAT1_ECOLI pepwindow swissprot:TRAT1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRAT1_ECOLI sigcleave swissprot:TRAT1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRAT1_ECOLI ## Database ID URL or Descriptions # BRENDA 3.4.21.88 2026 # BioGrid 4261718 9 # CATALYTIC ACTIVITY Hydrolysis of Ala-|-Gly bond in repressor LexA. {ECO:0000255|HAMAP-Rule MF_00015}. # EcoGene EG10533 lexA # FUNCTION LEXA_ECOLI Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. Implicated in hydroxy radical-mediated cell death induced by hydroxyurea treatment (PubMed 20005847).The SOS response controls an apoptotic-like death (ALD) induced (in the absence of the mazE-mazF toxin-antitoxin module) in response to DNA damaging agents that is mediated by RecA and LexA (PubMed 22412352). {ECO 0000255|HAMAP-Rule MF_00015, ECO 0000269|PubMed 20005847, ECO 0000269|PubMed 22412352, ECO 0000269|PubMed 7027255, ECO 0000269|PubMed 7027256}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IDA:EcoliWiki. # GO_function GO:0004252 serine-type endopeptidase activity; IEA:UniProtKB-HAMAP. # GO_process GO:0006260 DNA replication; IEA:UniProtKB-HAMAP. # GO_process GO:0006281 DNA repair; IEA:UniProtKB-HAMAP. # GO_process GO:0006351 transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IMP:EcoliWiki. # GO_process GO:0009432 SOS response; IMP:EcoCyc. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IMP:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0008233 peptidase activity # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # Gene3D 2.10.109.10 -; 1. # HAMAP MF_00015 LexA # IntAct P0A7C2 11 # InterPro IPR006197 Peptidase_S24_LexA # InterPro IPR006199 LexA_DNA-bd_dom # InterPro IPR006200 LexA # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR015927 Peptidase_S24_S26A/B/C # InterPro IPR019759 Peptidase_S24_S26 # InterPro IPR028360 Peptidase_S24/S26_b-rbn # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # KEGG_Brite ko03400 DNA repair and recombination proteins # Organism LEXA_ECOLI Escherichia coli (strain K12) # PATRIC 32123623 VBIEscCol129921_4160 # PDB 1JHC X-ray; 2.00 A; A=68-202 # PDB 1JHE X-ray; 2.50 A; A/B=68-202 # PDB 1JHF X-ray; 1.80 A; A/B=1-202 # PDB 1JHH X-ray; 2.10 A; A/B=1-202 # PDB 1LEA NMR; -; A=1-84 # PDB 1LEB NMR; -; A=1-84 # PDB 1MVD Model; -; A/B=1-202 # PDB 1QAA Model; -; A/B=1-202 # PDB 3JSO X-ray; 2.29 A; A/B=1-202 # PDB 3JSP X-ray; 2.90 A; A/B=1-202 # PDB 3K3R X-ray; 3.20 A; E/F=1-202 # PIR A90808 ILEC # PRINTS PR00726 LEXASERPTASE # Pfam PF00717 Peptidase_S24 # Pfam PF01726 LexA_DNA_bind # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LexA repressor {ECO:0000255|HAMAP-Rule MF_00015} # RefSeq NP_418467 NC_000913.3 # RefSeq WP_000646078 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase S24 family. {ECO:0000255|HAMAP-Rule MF_00015}. # SUBUNIT LEXA_ECOLI Homodimer. # SUPFAM SSF46785 SSF46785 # SUPFAM SSF51306 SSF51306 # TIGRFAMs TIGR00498 lexA # eggNOG COG1974 LUCA # eggNOG ENOG4105DS7 Bacteria BLAST swissprot:LEXA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LEXA_ECOLI BioCyc ECOL316407:JW4003-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4003-MONOMER BioCyc EcoCyc:PD00205 http://biocyc.org/getid?id=EcoCyc:PD00205 COG COG1974 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1974 DIP DIP-51082N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-51082N DOI 10.1002/prot.340210305 http://dx.doi.org/10.1002/prot.340210305 DOI 10.1007/BF00315795 http://dx.doi.org/10.1007/BF00315795 DOI 10.1016/0092-8674(81)90432-3 http://dx.doi.org/10.1016/0092-8674(81)90432-3 DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.78.7.4199 http://dx.doi.org/10.1073/pnas.78.7.4199 DOI 10.1073/pnas.78.7.4204 http://dx.doi.org/10.1073/pnas.78.7.4204 DOI 10.1073/pnas.86.18.6863 http://dx.doi.org/10.1073/pnas.86.18.6863 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1093/nar/9.16.4149 http://dx.doi.org/10.1093/nar/9.16.4149 DOI 10.1093/nar/9.3.529 http://dx.doi.org/10.1093/nar/9.3.529 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pbio.1001281 http://dx.doi.org/10.1371/journal.pbio.1001281 EC_number EC:3.4.21.88 {ECO:0000255|HAMAP-Rule:MF_00015} http://www.genome.jp/dbget-bin/www_bget?EC:3.4.21.88 {ECO:0000255|HAMAP-Rule:MF_00015} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01643 http://www.ebi.ac.uk/ena/data/view/J01643 EMBL L02362 http://www.ebi.ac.uk/ena/data/view/L02362 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.4.21.88 {ECO:0000255|HAMAP-Rule:MF_00015} http://enzyme.expasy.org/EC/3.4.21.88 {ECO:0000255|HAMAP-Rule:MF_00015} EchoBASE EB0528 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0528 EcoGene EG10533 http://www.ecogene.org/geneInfo.php?eg_id=EG10533 EnsemblBacteria AAC77013 http://www.ensemblgenomes.org/id/AAC77013 EnsemblBacteria AAC77013 http://www.ensemblgenomes.org/id/AAC77013 EnsemblBacteria BAE78045 http://www.ensemblgenomes.org/id/BAE78045 EnsemblBacteria BAE78045 http://www.ensemblgenomes.org/id/BAE78045 EnsemblBacteria BAE78045 http://www.ensemblgenomes.org/id/BAE78045 EnsemblBacteria b4043 http://www.ensemblgenomes.org/id/b4043 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004252 GO_process GO:0006260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260 GO_process GO:0006281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006281 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0009432 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009432 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 2.10.109.10 http://www.cathdb.info/version/latest/superfamily/2.10.109.10 GeneID 948544 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948544 HAMAP MF_00015 http://hamap.expasy.org/unirule/MF_00015 HOGENOM HOG000232167 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000232167&db=HOGENOM6 InParanoid P0A7C2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7C2 IntAct P0A7C2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7C2* IntEnz 3.4.21.88 {ECO:0000255|HAMAP-Rule:MF_00015} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.21.88 {ECO:0000255|HAMAP-Rule:MF_00015} InterPro IPR006197 http://www.ebi.ac.uk/interpro/entry/IPR006197 InterPro IPR006199 http://www.ebi.ac.uk/interpro/entry/IPR006199 InterPro IPR006200 http://www.ebi.ac.uk/interpro/entry/IPR006200 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR015927 http://www.ebi.ac.uk/interpro/entry/IPR015927 InterPro IPR019759 http://www.ebi.ac.uk/interpro/entry/IPR019759 InterPro IPR028360 http://www.ebi.ac.uk/interpro/entry/IPR028360 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW4003 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4003 KEGG_Gene eco:b4043 http://www.genome.jp/dbget-bin/www_bget?eco:b4043 KEGG_Orthology KO:K01356 http://www.genome.jp/dbget-bin/www_bget?KO:K01356 MINT MINT-1314348 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1314348 OMA KQHELLM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KQHELLM PDB 1JHC http://www.ebi.ac.uk/pdbe-srv/view/entry/1JHC PDB 1JHE http://www.ebi.ac.uk/pdbe-srv/view/entry/1JHE PDB 1JHF http://www.ebi.ac.uk/pdbe-srv/view/entry/1JHF PDB 1JHH http://www.ebi.ac.uk/pdbe-srv/view/entry/1JHH PDB 1LEA http://www.ebi.ac.uk/pdbe-srv/view/entry/1LEA PDB 1LEB http://www.ebi.ac.uk/pdbe-srv/view/entry/1LEB PDB 1MVD http://www.ebi.ac.uk/pdbe-srv/view/entry/1MVD PDB 1QAA http://www.ebi.ac.uk/pdbe-srv/view/entry/1QAA PDB 3JSO http://www.ebi.ac.uk/pdbe-srv/view/entry/3JSO PDB 3JSP http://www.ebi.ac.uk/pdbe-srv/view/entry/3JSP PDB 3K3R http://www.ebi.ac.uk/pdbe-srv/view/entry/3K3R PDBsum 1JHC http://www.ebi.ac.uk/pdbsum/1JHC PDBsum 1JHE http://www.ebi.ac.uk/pdbsum/1JHE PDBsum 1JHF http://www.ebi.ac.uk/pdbsum/1JHF PDBsum 1JHH http://www.ebi.ac.uk/pdbsum/1JHH PDBsum 1LEA http://www.ebi.ac.uk/pdbsum/1LEA PDBsum 1LEB http://www.ebi.ac.uk/pdbsum/1LEB PDBsum 1MVD http://www.ebi.ac.uk/pdbsum/1MVD PDBsum 1QAA http://www.ebi.ac.uk/pdbsum/1QAA PDBsum 3JSO http://www.ebi.ac.uk/pdbsum/3JSO PDBsum 3JSP http://www.ebi.ac.uk/pdbsum/3JSP PDBsum 3K3R http://www.ebi.ac.uk/pdbsum/3K3R PRINTS PR00726 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00726 PSORT swissprot:LEXA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LEXA_ECOLI PSORT-B swissprot:LEXA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LEXA_ECOLI PSORT2 swissprot:LEXA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LEXA_ECOLI Pfam PF00717 http://pfam.xfam.org/family/PF00717 Pfam PF01726 http://pfam.xfam.org/family/PF01726 Phobius swissprot:LEXA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LEXA_ECOLI PhylomeDB P0A7C2 http://phylomedb.org/?seqid=P0A7C2 ProteinModelPortal P0A7C2 http://www.proteinmodelportal.org/query/uniprot/P0A7C2 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 22412352 http://www.ncbi.nlm.nih.gov/pubmed/22412352 PubMed 2259342 http://www.ncbi.nlm.nih.gov/pubmed/2259342 PubMed 2780544 http://www.ncbi.nlm.nih.gov/pubmed/2780544 PubMed 6261224 http://www.ncbi.nlm.nih.gov/pubmed/6261224 PubMed 6272195 http://www.ncbi.nlm.nih.gov/pubmed/6272195 PubMed 7013987 http://www.ncbi.nlm.nih.gov/pubmed/7013987 PubMed 7027255 http://www.ncbi.nlm.nih.gov/pubmed/7027255 PubMed 7027256 http://www.ncbi.nlm.nih.gov/pubmed/7027256 PubMed 7784426 http://www.ncbi.nlm.nih.gov/pubmed/7784426 PubMed 8076591 http://www.ncbi.nlm.nih.gov/pubmed/8076591 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418467 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418467 RefSeq WP_000646078 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000646078 SMR P0A7C2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7C2 STRING 511145.b4043 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4043&targetmode=cogs STRING COG1974 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1974&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SUPFAM SSF51306 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51306 TIGRFAMs TIGR00498 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00498 UniProtKB LEXA_ECOLI http://www.uniprot.org/uniprot/LEXA_ECOLI UniProtKB-AC P0A7C2 http://www.uniprot.org/uniprot/P0A7C2 charge swissprot:LEXA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LEXA_ECOLI eggNOG COG1974 http://eggnogapi.embl.de/nog_data/html/tree/COG1974 eggNOG ENOG4105DS7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DS7 epestfind swissprot:LEXA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LEXA_ECOLI garnier swissprot:LEXA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LEXA_ECOLI helixturnhelix swissprot:LEXA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LEXA_ECOLI hmoment swissprot:LEXA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LEXA_ECOLI iep swissprot:LEXA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LEXA_ECOLI inforesidue swissprot:LEXA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LEXA_ECOLI octanol swissprot:LEXA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LEXA_ECOLI pepcoil swissprot:LEXA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LEXA_ECOLI pepdigest swissprot:LEXA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LEXA_ECOLI pepinfo swissprot:LEXA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LEXA_ECOLI pepnet swissprot:LEXA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LEXA_ECOLI pepstats swissprot:LEXA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LEXA_ECOLI pepwheel swissprot:LEXA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LEXA_ECOLI pepwindow swissprot:LEXA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LEXA_ECOLI sigcleave swissprot:LEXA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LEXA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260092 8 # CDD cd06261 TM_PBP2 # EcoGene EG10751 potC # FUNCTION POTC_ECOLI Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015417 polyamine-transporting ATPase activity; IMP:EcoCyc. # GO_process GO:0015846 polyamine transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # Gene3D 1.10.3720.10 -; 1. # InterPro IPR000515 MetI-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00299 Spermidine/putrescine transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism POTC_ECOLI Escherichia coli (strain K12) # PATRIC 32117495 VBIEscCol129921_1170 # PIR C40840 C40840 # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName POTC_ECOLI Spermidine/putrescine transport system permease protein PotC # RefSeq NP_415642 NC_000913.3 # RefSeq WP_000580316 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION POTC_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00441, ECO 0000269|PubMed 15919996}. # SUPFAM SSF161098 SSF161098 # TCDB 3.A.1.11 the atp-binding cassette (abc) superfamily # eggNOG COG1177 LUCA # eggNOG ENOG4105D38 Bacteria BLAST swissprot:POTC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:POTC_ECOLI BioCyc ECOL316407:JW1110-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1110-MONOMER BioCyc EcoCyc:POTC-MONOMER http://biocyc.org/getid?id=EcoCyc:POTC-MONOMER BioCyc MetaCyc:POTC-MONOMER http://biocyc.org/getid?id=MetaCyc:POTC-MONOMER COG COG1177 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1177 DIP DIP-48152N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48152N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M64519 http://www.ebi.ac.uk/ena/data/view/M64519 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0744 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0744 EcoGene EG10751 http://www.ecogene.org/geneInfo.php?eg_id=EG10751 EnsemblBacteria AAC74208 http://www.ensemblgenomes.org/id/AAC74208 EnsemblBacteria AAC74208 http://www.ensemblgenomes.org/id/AAC74208 EnsemblBacteria BAA35944 http://www.ensemblgenomes.org/id/BAA35944 EnsemblBacteria BAA35944 http://www.ensemblgenomes.org/id/BAA35944 EnsemblBacteria BAA35944 http://www.ensemblgenomes.org/id/BAA35944 EnsemblBacteria b1124 http://www.ensemblgenomes.org/id/b1124 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015417 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015417 GO_process GO:0015846 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015846 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 945691 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945691 HOGENOM HOG000263700 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000263700&db=HOGENOM6 InParanoid P0AFK6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFK6 IntAct P0AFK6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFK6* InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1110 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1110 KEGG_Gene eco:b1124 http://www.genome.jp/dbget-bin/www_bget?eco:b1124 KEGG_Orthology KO:K11070 http://www.genome.jp/dbget-bin/www_bget?KO:K11070 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 MINT MINT-1315836 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1315836 OMA NWYSLLM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NWYSLLM PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:POTC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:POTC_ECOLI PSORT-B swissprot:POTC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:POTC_ECOLI PSORT2 swissprot:POTC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:POTC_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Phobius swissprot:POTC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:POTC_ECOLI PhylomeDB P0AFK6 http://phylomedb.org/?seqid=P0AFK6 ProteinModelPortal P0AFK6 http://www.proteinmodelportal.org/query/uniprot/P0AFK6 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1939142 http://www.ncbi.nlm.nih.gov/pubmed/1939142 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415642 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415642 RefSeq WP_000580316 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000580316 STRING 511145.b1124 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1124&targetmode=cogs STRING COG1177 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1177&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.11 http://www.tcdb.org/search/result.php?tc=3.A.1.11 UniProtKB POTC_ECOLI http://www.uniprot.org/uniprot/POTC_ECOLI UniProtKB-AC P0AFK6 http://www.uniprot.org/uniprot/P0AFK6 charge swissprot:POTC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:POTC_ECOLI eggNOG COG1177 http://eggnogapi.embl.de/nog_data/html/tree/COG1177 eggNOG ENOG4105D38 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D38 epestfind swissprot:POTC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:POTC_ECOLI garnier swissprot:POTC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:POTC_ECOLI helixturnhelix swissprot:POTC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:POTC_ECOLI hmoment swissprot:POTC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:POTC_ECOLI iep swissprot:POTC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:POTC_ECOLI inforesidue swissprot:POTC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:POTC_ECOLI octanol swissprot:POTC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:POTC_ECOLI pepcoil swissprot:POTC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:POTC_ECOLI pepdigest swissprot:POTC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:POTC_ECOLI pepinfo swissprot:POTC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:POTC_ECOLI pepnet swissprot:POTC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:POTC_ECOLI pepstats swissprot:POTC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:POTC_ECOLI pepwheel swissprot:POTC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:POTC_ECOLI pepwindow swissprot:POTC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:POTC_ECOLI sigcleave swissprot:POTC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:POTC_ECOLI ## Database ID URL or Descriptions # BioGrid 4262087 14 # EcoGene EG12427 modA # FUNCTION MODA_ECOLI Involved in the transport of molybdenum into the cell. Binds molybdate with high specificity and affinity. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0015412 ATPase-coupled molybdate transmembrane transporter activity; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # InterPro IPR005950 Mo_ABC_perip-bd # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00189 Molybdate transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism MODA_ECOLI Escherichia coli (strain K12) # PATRIC 32116727 VBIEscCol129921_0789 # PDB 1AMF X-ray; 1.75 A; A=25-257 # PDB 1WOD X-ray; 1.75 A; A=25-257 # PDB 3AXF X-ray; 2.00 A; A/B/C=25-257 # PDB 3R26 X-ray; 1.70 A; A=25-257 # PDB 4XXU X-ray; 1.43 A; A/B=1-257 # PIR C64812 C64812 # PIRSF PIRSF004846 ModA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MODA_ECOLI Molybdate-binding periplasmic protein # RefSeq NP_415284 NC_000913.3 # RefSeq WP_000101984 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial solute-binding protein ModA family. {ECO 0000305}. # SUBCELLULAR LOCATION MODA_ECOLI Periplasm. # TCDB 3.A.1.8 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR01256 modA # eggNOG COG0725 LUCA # eggNOG ENOG4108S6J Bacteria BLAST swissprot:MODA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MODA_ECOLI BioCyc ECOL316407:JW0746-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0746-MONOMER BioCyc EcoCyc:MODA-MONOMER http://biocyc.org/getid?id=EcoCyc:MODA-MONOMER BioCyc MetaCyc:MODA-MONOMER http://biocyc.org/getid?id=MetaCyc:MODA-MONOMER COG COG0725 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0725 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb0997-703 http://dx.doi.org/10.1038/nsb0997-703 DOI 10.1074/jbc.271.5.2557 http://dx.doi.org/10.1074/jbc.271.5.2557 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L34009 http://www.ebi.ac.uk/ena/data/view/L34009 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U07867 http://www.ebi.ac.uk/ena/data/view/U07867 EMBL U27192 http://www.ebi.ac.uk/ena/data/view/U27192 EchoBASE EB2325 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2325 EcoGene EG12427 http://www.ecogene.org/geneInfo.php?eg_id=EG12427 EnsemblBacteria AAC73850 http://www.ensemblgenomes.org/id/AAC73850 EnsemblBacteria AAC73850 http://www.ensemblgenomes.org/id/AAC73850 EnsemblBacteria BAA35427 http://www.ensemblgenomes.org/id/BAA35427 EnsemblBacteria BAA35427 http://www.ensemblgenomes.org/id/BAA35427 EnsemblBacteria BAA35427 http://www.ensemblgenomes.org/id/BAA35427 EnsemblBacteria b0763 http://www.ensemblgenomes.org/id/b0763 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0015412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015412 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GeneID 945364 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945364 HOGENOM HOG000280537 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000280537&db=HOGENOM6 InParanoid P37329 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37329 IntAct P37329 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37329* InterPro IPR005950 http://www.ebi.ac.uk/interpro/entry/IPR005950 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0746 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0746 KEGG_Gene eco:b0763 http://www.genome.jp/dbget-bin/www_bget?eco:b0763 KEGG_Orthology KO:K02020 http://www.genome.jp/dbget-bin/www_bget?KO:K02020 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA LTHENLW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LTHENLW PDB 1AMF http://www.ebi.ac.uk/pdbe-srv/view/entry/1AMF PDB 1WOD http://www.ebi.ac.uk/pdbe-srv/view/entry/1WOD PDB 3AXF http://www.ebi.ac.uk/pdbe-srv/view/entry/3AXF PDB 3R26 http://www.ebi.ac.uk/pdbe-srv/view/entry/3R26 PDB 4XXU http://www.ebi.ac.uk/pdbe-srv/view/entry/4XXU PDBsum 1AMF http://www.ebi.ac.uk/pdbsum/1AMF PDBsum 1WOD http://www.ebi.ac.uk/pdbsum/1WOD PDBsum 3AXF http://www.ebi.ac.uk/pdbsum/3AXF PDBsum 3R26 http://www.ebi.ac.uk/pdbsum/3R26 PDBsum 4XXU http://www.ebi.ac.uk/pdbsum/4XXU PSORT swissprot:MODA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MODA_ECOLI PSORT-B swissprot:MODA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MODA_ECOLI PSORT2 swissprot:MODA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MODA_ECOLI Phobius swissprot:MODA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MODA_ECOLI PhylomeDB P37329 http://phylomedb.org/?seqid=P37329 ProteinModelPortal P37329 http://www.proteinmodelportal.org/query/uniprot/P37329 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7860583 http://www.ncbi.nlm.nih.gov/pubmed/7860583 PubMed 8564363 http://www.ncbi.nlm.nih.gov/pubmed/8564363 PubMed 8576221 http://www.ncbi.nlm.nih.gov/pubmed/8576221 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9302996 http://www.ncbi.nlm.nih.gov/pubmed/9302996 RefSeq NP_415284 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415284 RefSeq WP_000101984 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000101984 SMR P37329 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37329 STRING 511145.b0763 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0763&targetmode=cogs STRING COG0725 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0725&targetmode=cogs SWISS-2DPAGE P37329 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P37329 TCDB 3.A.1.8 http://www.tcdb.org/search/result.php?tc=3.A.1.8 TIGRFAMs TIGR01256 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01256 UniProtKB MODA_ECOLI http://www.uniprot.org/uniprot/MODA_ECOLI UniProtKB-AC P37329 http://www.uniprot.org/uniprot/P37329 charge swissprot:MODA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MODA_ECOLI eggNOG COG0725 http://eggnogapi.embl.de/nog_data/html/tree/COG0725 eggNOG ENOG4108S6J http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108S6J epestfind swissprot:MODA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MODA_ECOLI garnier swissprot:MODA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MODA_ECOLI helixturnhelix swissprot:MODA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MODA_ECOLI hmoment swissprot:MODA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MODA_ECOLI iep swissprot:MODA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MODA_ECOLI inforesidue swissprot:MODA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MODA_ECOLI octanol swissprot:MODA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MODA_ECOLI pepcoil swissprot:MODA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MODA_ECOLI pepdigest swissprot:MODA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MODA_ECOLI pepinfo swissprot:MODA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MODA_ECOLI pepnet swissprot:MODA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MODA_ECOLI pepstats swissprot:MODA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MODA_ECOLI pepwheel swissprot:MODA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MODA_ECOLI pepwindow swissprot:MODA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MODA_ECOLI sigcleave swissprot:MODA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MODA_ECOLI ## Database ID URL or Descriptions # AltName CYNT_ECOLI Carbonate dehydratase 1 # BioGrid 4259815 4 # CATALYTIC ACTIVITY H(2)CO(3) = CO(2) + H(2)O. {ECO:0000269|PubMed 1740425}. # COFACTOR CYNT_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 1740425}; Note=Binds 1 zinc ion per subunit. {ECO 0000269|PubMed 1740425}; # EcoGene EG10176 cynT # FUNCTION CYNT_ECOLI Reversible hydration of carbon dioxide. Carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (CynS) diffuses out of the cell faster than it would be hydrated to bicarbonate, so the apparent function of this enzyme is to catalyze the hydration of carbon dioxide and thus prevent depletion of cellular bicarbonate. {ECO 0000269|PubMed 1740425}. # GO_component GO:0005737 cytoplasm; IDA:EcoCyc. # GO_function GO:0004089 carbonate dehydratase activity; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0009440 cyanate catabolic process; IMP:EcoCyc. # GO_process GO:0015976 carbon utilization; IEA:InterPro. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.1050.10 -; 1. # INDUCTION By cyanate. {ECO:0000269|PubMed 1740425}. # InterPro IPR001765 Carbonic_anhydrase # InterPro IPR015892 Carbonic_anhydrase_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00910 Nitrogen metabolism # Organism CYNT_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11002 PTHR11002 # PATRIC 32115811 VBIEscCol129921_0347 # PIR C64761 QRECTC # PROSITE PS00704 PROK_CO2_ANHYDRASE_1 # PROSITE PS00705 PROK_CO2_ANHYDRASE_2 # Pfam PF00484 Pro_CA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CYNT_ECOLI Carbonic anhydrase 1 # RefSeq NP_414873 NC_000913.3 # RefSeq WP_000658652 NZ_LN832404.1 # SIMILARITY Belongs to the beta-class carbonic anhydrase family. {ECO 0000305}. # SMART SM00947 Pro_CA # SUBUNIT Oligomer. {ECO:0000269|PubMed 1740425}. # SUPFAM SSF53056 SSF53056 # eggNOG COG0288 LUCA # eggNOG ENOG4107B2H Bacteria BLAST swissprot:CYNT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CYNT_ECOLI BioCyc ECOL316407:JW0330-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0330-MONOMER BioCyc EcoCyc:CARBODEHYDRAT-MONOMER http://biocyc.org/getid?id=EcoCyc:CARBODEHYDRAT-MONOMER BioCyc MetaCyc:CARBODEHYDRAT-MONOMER http://biocyc.org/getid?id=MetaCyc:CARBODEHYDRAT-MONOMER COG COG0288 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0288 DIP DIP-47965N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47965N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.1.1 {ECO:0000269|PubMed:1740425} http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.1 {ECO:0000269|PubMed:1740425} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M23219 http://www.ebi.ac.uk/ena/data/view/M23219 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 ENZYME 4.2.1.1 {ECO:0000269|PubMed:1740425} http://enzyme.expasy.org/EC/4.2.1.1 {ECO:0000269|PubMed:1740425} EchoBASE EB0173 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0173 EcoGene EG10176 http://www.ecogene.org/geneInfo.php?eg_id=EG10176 EnsemblBacteria AAC73442 http://www.ensemblgenomes.org/id/AAC73442 EnsemblBacteria AAC73442 http://www.ensemblgenomes.org/id/AAC73442 EnsemblBacteria BAE76121 http://www.ensemblgenomes.org/id/BAE76121 EnsemblBacteria BAE76121 http://www.ensemblgenomes.org/id/BAE76121 EnsemblBacteria BAE76121 http://www.ensemblgenomes.org/id/BAE76121 EnsemblBacteria b0339 http://www.ensemblgenomes.org/id/b0339 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004089 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004089 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0009440 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009440 GO_process GO:0015976 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015976 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.1050.10 http://www.cathdb.info/version/latest/superfamily/3.40.1050.10 GeneID 946548 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946548 HOGENOM HOG000125182 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125182&db=HOGENOM6 InParanoid P0ABE9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABE9 IntAct P0ABE9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABE9* IntEnz 4.2.1.1 {ECO:0000269|PubMed:1740425} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.1 {ECO:0000269|PubMed:1740425} InterPro IPR001765 http://www.ebi.ac.uk/interpro/entry/IPR001765 InterPro IPR015892 http://www.ebi.ac.uk/interpro/entry/IPR015892 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0330 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0330 KEGG_Gene eco:b0339 http://www.genome.jp/dbget-bin/www_bget?eco:b0339 KEGG_Orthology KO:K01673 http://www.genome.jp/dbget-bin/www_bget?KO:K01673 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Reaction rn:R00132 http://www.genome.jp/dbget-bin/www_bget?rn:R00132 KEGG_Reaction rn:R10092 http://www.genome.jp/dbget-bin/www_bget?rn:R10092 OMA NIIICGH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NIIICGH PANTHER PTHR11002 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11002 PROSITE PS00704 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00704 PROSITE PS00705 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00705 PSORT swissprot:CYNT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CYNT_ECOLI PSORT-B swissprot:CYNT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CYNT_ECOLI PSORT2 swissprot:CYNT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CYNT_ECOLI Pfam PF00484 http://pfam.xfam.org/family/PF00484 Phobius swissprot:CYNT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CYNT_ECOLI PhylomeDB P0ABE9 http://phylomedb.org/?seqid=P0ABE9 ProteinModelPortal P0ABE9 http://www.proteinmodelportal.org/query/uniprot/P0ABE9 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1740425 http://www.ncbi.nlm.nih.gov/pubmed/1740425 PubMed 3049588 http://www.ncbi.nlm.nih.gov/pubmed/3049588 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414873 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414873 RefSeq WP_000658652 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000658652 SMART SM00947 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00947 SMR P0ABE9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABE9 STRING 511145.b0339 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0339&targetmode=cogs STRING COG0288 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0288&targetmode=cogs SUPFAM SSF53056 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53056 UniProtKB CYNT_ECOLI http://www.uniprot.org/uniprot/CYNT_ECOLI UniProtKB-AC P0ABE9 http://www.uniprot.org/uniprot/P0ABE9 charge swissprot:CYNT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CYNT_ECOLI eggNOG COG0288 http://eggnogapi.embl.de/nog_data/html/tree/COG0288 eggNOG ENOG4107B2H http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107B2H epestfind swissprot:CYNT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CYNT_ECOLI garnier swissprot:CYNT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CYNT_ECOLI helixturnhelix swissprot:CYNT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CYNT_ECOLI hmoment swissprot:CYNT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CYNT_ECOLI iep swissprot:CYNT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CYNT_ECOLI inforesidue swissprot:CYNT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CYNT_ECOLI octanol swissprot:CYNT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CYNT_ECOLI pepcoil swissprot:CYNT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CYNT_ECOLI pepdigest swissprot:CYNT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CYNT_ECOLI pepinfo swissprot:CYNT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CYNT_ECOLI pepnet swissprot:CYNT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CYNT_ECOLI pepstats swissprot:CYNT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CYNT_ECOLI pepwheel swissprot:CYNT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CYNT_ECOLI pepwindow swissprot:CYNT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CYNT_ECOLI sigcleave swissprot:CYNT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CYNT_ECOLI ## Database ID URL or Descriptions # BioGrid 4260637 272 # DISRUPTION PHENOTYPE Disruption of tatE affects the correct localization of multiple enzymes whose precursors bear twin arginine transfer peptides. Export is completely blocked when both tatA and tatE are inactivated. {ECO:0000269|PubMed 9649434}. # EcoGene EG11305 tatE # FUNCTION TATE_ECOLI Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA. {ECO 0000255|HAMAP- Rule MF_00903, ECO 0000269|PubMed 9649434}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; ISO:EcoCyc. # GO_component GO:0033281 TAT protein transport complex; IMP:EcoCyc. # GO_function GO:0008320 protein transmembrane transporter activity; IEA:UniProtKB-HAMAP. # GO_function GO:0008565 protein transporter activity; IMP:EcoCyc. # GO_process GO:0009306 protein secretion; IEA:InterPro. # GO_process GO:0043953 protein transport by the Tat complex; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0008565 protein transporter activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # HAMAP MF_00236 TatA_E # HAMAP MF_00903 TatE # INDUCTION Constitutively expressed. {ECO:0000269|PubMed 11160116}. # IntAct P0A843 53 # InterPro IPR003369 TatA/B/E # InterPro IPR006312 TatA/E # InterPro IPR024905 TatE # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02044 M00336 Twin-arginine translocation (Tat) system # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko03060 Protein export # KEGG_Pathway ko03070 Bacterial secretion system # Organism TATE_ECOLI Escherichia coli (strain K12) # PATRIC 32116435 VBIEscCol129921_0657 # PIR JN0256 JN0256 # Pfam PF02416 MttA_Hcf106 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TATE_ECOLI Sec-independent protein translocase protein TatE # RefSeq NP_415160 NC_000913.3 # RefSeq WP_000503931 NZ_LN832404.1 # SIMILARITY Belongs to the TatA/E family. TatE subfamily. {ECO:0000255|HAMAP-Rule MF_00903}. # SUBCELLULAR LOCATION TATE_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_00903}; Single-pass membrane protein {ECO 0000255|HAMAP- Rule MF_00903}. # TCDB 2.A.64.1 the twin arginine targeting (tat) family # TIGRFAMs TIGR01411 tatAE # eggNOG COG1826 LUCA # eggNOG ENOG410607N Bacteria BLAST swissprot:TATE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TATE_ECOLI BioCyc ECOL316407:JW0622-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0622-MONOMER BioCyc EcoCyc:EG11305-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11305-MONOMER BioCyc MetaCyc:EG11305-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11305-MONOMER COG COG1826 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1826 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2000.01719.x http://dx.doi.org/10.1046/j.1365-2958.2000.01719.x DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/emboj/17.13.3640 http://dx.doi.org/10.1093/emboj/17.13.3640 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.183.5.1801-1804.2001 http://dx.doi.org/10.1128/JB.183.5.1801-1804.2001 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M82805 http://www.ebi.ac.uk/ena/data/view/M82805 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB1282 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1282 EcoGene EG11305 http://www.ecogene.org/geneInfo.php?eg_id=EG11305 EnsemblBacteria AAC73728 http://www.ensemblgenomes.org/id/AAC73728 EnsemblBacteria AAC73728 http://www.ensemblgenomes.org/id/AAC73728 EnsemblBacteria BAA35270 http://www.ensemblgenomes.org/id/BAA35270 EnsemblBacteria BAA35270 http://www.ensemblgenomes.org/id/BAA35270 EnsemblBacteria BAA35270 http://www.ensemblgenomes.org/id/BAA35270 EnsemblBacteria b0627 http://www.ensemblgenomes.org/id/b0627 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0033281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033281 GO_function GO:0008320 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008320 GO_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GO_process GO:0009306 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009306 GO_process GO:0043953 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043953 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 945228 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945228 HAMAP MF_00236 http://hamap.expasy.org/unirule/MF_00236 HAMAP MF_00903 http://hamap.expasy.org/unirule/MF_00903 HOGENOM HOG000245363 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000245363&db=HOGENOM6 InParanoid P0A843 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A843 IntAct P0A843 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A843* InterPro IPR003369 http://www.ebi.ac.uk/interpro/entry/IPR003369 InterPro IPR006312 http://www.ebi.ac.uk/interpro/entry/IPR006312 InterPro IPR024905 http://www.ebi.ac.uk/interpro/entry/IPR024905 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW0622 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0622 KEGG_Gene eco:b0627 http://www.genome.jp/dbget-bin/www_bget?eco:b0627 KEGG_Orthology KO:K03425 http://www.genome.jp/dbget-bin/www_bget?KO:K03425 KEGG_Pathway ko03060 http://www.genome.jp/kegg-bin/show_pathway?ko03060 KEGG_Pathway ko03070 http://www.genome.jp/kegg-bin/show_pathway?ko03070 OMA DEDKPNA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DEDKPNA PSORT swissprot:TATE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TATE_ECOLI PSORT-B swissprot:TATE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TATE_ECOLI PSORT2 swissprot:TATE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TATE_ECOLI Pfam PF02416 http://pfam.xfam.org/family/PF02416 Phobius swissprot:TATE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TATE_ECOLI ProteinModelPortal P0A843 http://www.proteinmodelportal.org/query/uniprot/P0A843 PubMed 10652088 http://www.ncbi.nlm.nih.gov/pubmed/10652088 PubMed 11160116 http://www.ncbi.nlm.nih.gov/pubmed/11160116 PubMed 1577793 http://www.ncbi.nlm.nih.gov/pubmed/1577793 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9649434 http://www.ncbi.nlm.nih.gov/pubmed/9649434 RefSeq NP_415160 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415160 RefSeq WP_000503931 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000503931 SMR P0A843 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A843 STRING 511145.b0627 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0627&targetmode=cogs STRING COG1826 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1826&targetmode=cogs TCDB 2.A.64.1 http://www.tcdb.org/search/result.php?tc=2.A.64.1 TIGRFAMs TIGR01411 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01411 UniProtKB TATE_ECOLI http://www.uniprot.org/uniprot/TATE_ECOLI UniProtKB-AC P0A843 http://www.uniprot.org/uniprot/P0A843 charge swissprot:TATE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TATE_ECOLI eggNOG COG1826 http://eggnogapi.embl.de/nog_data/html/tree/COG1826 eggNOG ENOG410607N http://eggnogapi.embl.de/nog_data/html/tree/ENOG410607N epestfind swissprot:TATE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TATE_ECOLI garnier swissprot:TATE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TATE_ECOLI helixturnhelix swissprot:TATE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TATE_ECOLI hmoment swissprot:TATE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TATE_ECOLI iep swissprot:TATE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TATE_ECOLI inforesidue swissprot:TATE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TATE_ECOLI octanol swissprot:TATE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TATE_ECOLI pepcoil swissprot:TATE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TATE_ECOLI pepdigest swissprot:TATE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TATE_ECOLI pepinfo swissprot:TATE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TATE_ECOLI pepnet swissprot:TATE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TATE_ECOLI pepstats swissprot:TATE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TATE_ECOLI pepwheel swissprot:TATE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TATE_ECOLI pepwindow swissprot:TATE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TATE_ECOLI sigcleave swissprot:TATE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TATE_ECOLI ## Database ID URL or Descriptions # BioGrid 4262745 4 # EcoGene EG12559 yjhQ # GO_component GO:0031248 protein acetyltransferase complex; IBA:GO_Central. # GO_function GO:0004596 peptide alpha-N-acetyltransferase activity; IBA:GO_Central. # GO_process GO:0006474 N-terminal protein amino acid acetylation; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0006464 cellular protein modification process # Gene3D 3.40.630.30 -; 1. # InterPro IPR000182 GNAT_dom # InterPro IPR016181 Acyl_CoA_acyltransferase # Organism YJHQ_ECOLI Escherichia coli (strain K12) # PATRIC 32124202 VBIEscCol129921_4444 # PIR S56532 S56532 # PROSITE PS51186 GNAT # Pfam PF00583 Acetyltransf_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJHQ_ECOLI Uncharacterized N-acetyltransferase YjhQ # RefSeq NP_418727 NC_000913.3 # RefSeq WP_001309181 NZ_LN832404.1 # SIMILARITY Belongs to the acetyltransferase family. {ECO 0000305}. # SIMILARITY Contains 1 N-acetyltransferase domain. {ECO:0000255|PROSITE-ProRule PRU00532}. # SUPFAM SSF55729 SSF55729 # eggNOG COG3153 LUCA # eggNOG ENOG41080VW Bacteria BLAST swissprot:YJHQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJHQ_ECOLI BioCyc ECOL316407:JW4269-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4269-MONOMER BioCyc EcoCyc:G7917-MONOMER http://biocyc.org/getid?id=EcoCyc:G7917-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 2.3.1.- http://enzyme.expasy.org/EC/2.3.1.- EchoBASE EB2447 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2447 EcoGene EG12559 http://www.ecogene.org/geneInfo.php?eg_id=EG12559 EnsemblBacteria AAC77263 http://www.ensemblgenomes.org/id/AAC77263 EnsemblBacteria AAC77263 http://www.ensemblgenomes.org/id/AAC77263 EnsemblBacteria BAE78299 http://www.ensemblgenomes.org/id/BAE78299 EnsemblBacteria BAE78299 http://www.ensemblgenomes.org/id/BAE78299 EnsemblBacteria BAE78299 http://www.ensemblgenomes.org/id/BAE78299 EnsemblBacteria b4307 http://www.ensemblgenomes.org/id/b4307 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0031248 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031248 GO_function GO:0004596 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004596 GO_process GO:0006474 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006474 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 Gene3D 3.40.630.30 http://www.cathdb.info/version/latest/superfamily/3.40.630.30 GeneID 949059 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949059 HOGENOM HOG000031671 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000031671&db=HOGENOM6 InParanoid P39368 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39368 IntAct P39368 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39368* IntEnz 2.3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1 InterPro IPR000182 http://www.ebi.ac.uk/interpro/entry/IPR000182 InterPro IPR016181 http://www.ebi.ac.uk/interpro/entry/IPR016181 KEGG_Gene ecj:JW4269 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4269 KEGG_Gene eco:b4307 http://www.genome.jp/dbget-bin/www_bget?eco:b4307 OMA ILGHETY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ILGHETY PROSITE PS51186 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51186 PSORT swissprot:YJHQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJHQ_ECOLI PSORT-B swissprot:YJHQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJHQ_ECOLI PSORT2 swissprot:YJHQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJHQ_ECOLI Pfam PF00583 http://pfam.xfam.org/family/PF00583 Phobius swissprot:YJHQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJHQ_ECOLI PhylomeDB P39368 http://phylomedb.org/?seqid=P39368 ProteinModelPortal P39368 http://www.proteinmodelportal.org/query/uniprot/P39368 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418727 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418727 RefSeq WP_001309181 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001309181 SMR P39368 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39368 STRING 511145.b4307 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4307&targetmode=cogs SUPFAM SSF55729 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55729 UniProtKB YJHQ_ECOLI http://www.uniprot.org/uniprot/YJHQ_ECOLI UniProtKB-AC P39368 http://www.uniprot.org/uniprot/P39368 charge swissprot:YJHQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJHQ_ECOLI eggNOG COG3153 http://eggnogapi.embl.de/nog_data/html/tree/COG3153 eggNOG ENOG41080VW http://eggnogapi.embl.de/nog_data/html/tree/ENOG41080VW epestfind swissprot:YJHQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJHQ_ECOLI garnier swissprot:YJHQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJHQ_ECOLI helixturnhelix swissprot:YJHQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJHQ_ECOLI hmoment swissprot:YJHQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJHQ_ECOLI iep swissprot:YJHQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJHQ_ECOLI inforesidue swissprot:YJHQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJHQ_ECOLI octanol swissprot:YJHQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJHQ_ECOLI pepcoil swissprot:YJHQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJHQ_ECOLI pepdigest swissprot:YJHQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJHQ_ECOLI pepinfo swissprot:YJHQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJHQ_ECOLI pepnet swissprot:YJHQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJHQ_ECOLI pepstats swissprot:YJHQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJHQ_ECOLI pepwheel swissprot:YJHQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJHQ_ECOLI pepwindow swissprot:YJHQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJHQ_ECOLI sigcleave swissprot:YJHQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJHQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4260002 16 # EcoGene EG13693 ybjX # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_process GO:0006950 response to stress # IntAct P75829 47 # InterPro IPR007488 DUF535 # Organism YBJX_ECOLI Escherichia coli (strain K12) # PATRIC 32116961 VBIEscCol129921_0906 # PIR E64826 E64826 # Pfam PF04393 DUF535 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBJX_ECOLI Uncharacterized protein YbjX # RefSeq NP_415398 NC_000913.3 # RefSeq WP_000241033 NZ_LN832404.1 # SIMILARITY To H.influenzae HI_0461. {ECO 0000305}. # eggNOG COG2990 LUCA # eggNOG ENOG4108MJ5 Bacteria BLAST swissprot:YBJX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBJX_ECOLI BioCyc ECOL316407:JW0861-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0861-MONOMER BioCyc EcoCyc:G6460-MONOMER http://biocyc.org/getid?id=EcoCyc:G6460-MONOMER COG COG2990 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2990 DIP DIP-11459N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11459N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3457 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3457 EcoGene EG13693 http://www.ecogene.org/geneInfo.php?eg_id=EG13693 EnsemblBacteria AAC73964 http://www.ensemblgenomes.org/id/AAC73964 EnsemblBacteria AAC73964 http://www.ensemblgenomes.org/id/AAC73964 EnsemblBacteria BAA35595 http://www.ensemblgenomes.org/id/BAA35595 EnsemblBacteria BAA35595 http://www.ensemblgenomes.org/id/BAA35595 EnsemblBacteria BAA35595 http://www.ensemblgenomes.org/id/BAA35595 EnsemblBacteria b0877 http://www.ensemblgenomes.org/id/b0877 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 946025 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946025 HOGENOM HOG000118282 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118282&db=HOGENOM6 IntAct P75829 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75829* InterPro IPR007488 http://www.ebi.ac.uk/interpro/entry/IPR007488 KEGG_Gene ecj:JW0861 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0861 KEGG_Gene eco:b0877 http://www.genome.jp/dbget-bin/www_bget?eco:b0877 KEGG_Orthology KO:K09824 http://www.genome.jp/dbget-bin/www_bget?KO:K09824 MINT MINT-1218149 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1218149 OMA RRYEWLD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RRYEWLD PSORT swissprot:YBJX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBJX_ECOLI PSORT-B swissprot:YBJX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBJX_ECOLI PSORT2 swissprot:YBJX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBJX_ECOLI Pfam PF04393 http://pfam.xfam.org/family/PF04393 Phobius swissprot:YBJX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBJX_ECOLI ProteinModelPortal P75829 http://www.proteinmodelportal.org/query/uniprot/P75829 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415398 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415398 RefSeq WP_000241033 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000241033 STRING 511145.b0877 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0877&targetmode=cogs STRING COG2990 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2990&targetmode=cogs UniProtKB YBJX_ECOLI http://www.uniprot.org/uniprot/YBJX_ECOLI UniProtKB-AC P75829 http://www.uniprot.org/uniprot/P75829 charge swissprot:YBJX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBJX_ECOLI eggNOG COG2990 http://eggnogapi.embl.de/nog_data/html/tree/COG2990 eggNOG ENOG4108MJ5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MJ5 epestfind swissprot:YBJX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBJX_ECOLI garnier swissprot:YBJX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBJX_ECOLI helixturnhelix swissprot:YBJX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBJX_ECOLI hmoment swissprot:YBJX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBJX_ECOLI iep swissprot:YBJX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBJX_ECOLI inforesidue swissprot:YBJX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBJX_ECOLI octanol swissprot:YBJX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBJX_ECOLI pepcoil swissprot:YBJX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBJX_ECOLI pepdigest swissprot:YBJX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBJX_ECOLI pepinfo swissprot:YBJX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBJX_ECOLI pepnet swissprot:YBJX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBJX_ECOLI pepstats swissprot:YBJX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBJX_ECOLI pepwheel swissprot:YBJX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBJX_ECOLI pepwindow swissprot:YBJX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBJX_ECOLI sigcleave swissprot:YBJX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBJX_ECOLI ## Database ID URL or Descriptions # BioGrid 4260114 394 # EcoGene EG10678 oppF # FUNCTION OPPF_ECOLI Part of the binding-protein-dependent transport system for oligopeptides. Probably responsible for energy coupling to the transport system. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016887 ATPase activity; IEA:InterPro. # GO_process GO:0015031 protein transport; IEA:UniProtKB-KW. # GO_process GO:0015833 peptide transport; IEA:UniProtKB-KW. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # Gene3D 3.40.50.300 -; 1. # IntAct P77737 7 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR013563 Oligopep_ABC_C # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00439 Oligopeptide transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism OPPF_ECOLI Escherichia coli (strain K12) # PATRIC 32117754 VBIEscCol129921_1297 # PIR B64872 B64872 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # Pfam PF00005 ABC_tran # Pfam PF08352 oligo_HPY # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName OPPF_ECOLI Oligopeptide transport ATP-binding protein OppF # RefSeq NP_415763 NC_000913.3 # SIMILARITY Belongs to the ABC transporter superfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA # SUBCELLULAR LOCATION OPPF_ECOLI Cell inner membrane; Peripheral membrane protein. # SUPFAM SSF52540 SSF52540 # TCDB 3.A.1.5.41 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR01727 oligo_HPY # eggNOG COG4608 LUCA # eggNOG ENOG4108JQ7 Bacteria BLAST swissprot:OPPF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:OPPF_ECOLI BioCyc ECOL316407:JW1239-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1239-MONOMER BioCyc EcoCyc:OPPF-MONOMER http://biocyc.org/getid?id=EcoCyc:OPPF-MONOMER BioCyc MetaCyc:OPPF-MONOMER http://biocyc.org/getid?id=MetaCyc:OPPF-MONOMER COG COG4608 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4608 DIP DIP-10409N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10409N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0672 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0672 EcoGene EG10678 http://www.ecogene.org/geneInfo.php?eg_id=EG10678 EnsemblBacteria AAC74329 http://www.ensemblgenomes.org/id/AAC74329 EnsemblBacteria AAC74329 http://www.ensemblgenomes.org/id/AAC74329 EnsemblBacteria BAA14779 http://www.ensemblgenomes.org/id/BAA14779 EnsemblBacteria BAA14779 http://www.ensemblgenomes.org/id/BAA14779 EnsemblBacteria BAA14779 http://www.ensemblgenomes.org/id/BAA14779 EnsemblBacteria b1247 http://www.ensemblgenomes.org/id/b1247 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_process GO:0015031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031 GO_process GO:0015833 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015833 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945818 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945818 InParanoid P77737 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77737 IntAct P77737 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77737* InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR013563 http://www.ebi.ac.uk/interpro/entry/IPR013563 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1239 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1239 KEGG_Gene eco:b1247 http://www.genome.jp/dbget-bin/www_bget?eco:b1247 KEGG_Orthology KO:K10823 http://www.genome.jp/dbget-bin/www_bget?KO:K10823 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA ATTWERI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ATTWERI PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:OPPF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:OPPF_ECOLI PSORT-B swissprot:OPPF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:OPPF_ECOLI PSORT2 swissprot:OPPF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:OPPF_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Pfam PF08352 http://pfam.xfam.org/family/PF08352 Phobius swissprot:OPPF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:OPPF_ECOLI PhylomeDB P77737 http://phylomedb.org/?seqid=P77737 ProteinModelPortal P77737 http://www.proteinmodelportal.org/query/uniprot/P77737 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415763 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415763 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P77737 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77737 STRING 511145.b1247 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1247&targetmode=cogs STRING COG4608 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4608&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.5.41 http://www.tcdb.org/search/result.php?tc=3.A.1.5.41 TIGRFAMs TIGR01727 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01727 UniProtKB OPPF_ECOLI http://www.uniprot.org/uniprot/OPPF_ECOLI UniProtKB-AC P77737 http://www.uniprot.org/uniprot/P77737 charge swissprot:OPPF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:OPPF_ECOLI eggNOG COG4608 http://eggnogapi.embl.de/nog_data/html/tree/COG4608 eggNOG ENOG4108JQ7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108JQ7 epestfind swissprot:OPPF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:OPPF_ECOLI garnier swissprot:OPPF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:OPPF_ECOLI helixturnhelix swissprot:OPPF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:OPPF_ECOLI hmoment swissprot:OPPF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:OPPF_ECOLI iep swissprot:OPPF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:OPPF_ECOLI inforesidue swissprot:OPPF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:OPPF_ECOLI octanol swissprot:OPPF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:OPPF_ECOLI pepcoil swissprot:OPPF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:OPPF_ECOLI pepdigest swissprot:OPPF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:OPPF_ECOLI pepinfo swissprot:OPPF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:OPPF_ECOLI pepnet swissprot:OPPF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:OPPF_ECOLI pepstats swissprot:OPPF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:OPPF_ECOLI pepwheel swissprot:OPPF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:OPPF_ECOLI pepwindow swissprot:OPPF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:OPPF_ECOLI sigcleave swissprot:OPPF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:OPPF_ECOLI ## Database ID URL or Descriptions # AltName RSEP_ECOLI S2P endopeptidase # AltName RSEP_ECOLI Site-2 protease RseP # AltName RSEP_ECOLI Site-2-type intramembrane protease # BioGrid 4261736 75 # CAUTION Was originally thought to be a negative regulator of sigma-E function and to act directly on sigma-E and RpoH; this may not be physiologically relevant. {ECO:0000305|PubMed 11689431}. # COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI 29105; Evidence={ECO:0000305}; # DISRUPTION PHENOTYPE RSEP_ECOLI Essential. Depletion experiments lead to cessation of growth, elongated cells and limited lysis, as well as decreased amounts of sigma-E. Not essential in an rseA deletion strain, when sigma-E is overexpressed or in ompA-ompC deletion strain. In the latter has severely decreased growth at 20 degrees Celsius. Accumulation of an RseA proteolysis intermediate. {ECO 0000269|PubMed 11274153, ECO 0000269|PubMed 11689431, ECO 0000269|PubMed 11750129, ECO 0000269|PubMed 12183368, ECO 0000269|PubMed 12183369, ECO 0000269|PubMed 23016873}. # DOMAIN RSEP_ECOLI The 2 circularly premutated PDZ domains act to negatively regulate protease action on intact RseA; mutations in PDZ-N have a more deleterious effect than similar mutations in PDZ-C. A 31 residue insertion in PDZ-C (between Val-261 and Met-262) domain inhibits protease activity, whereas deletion of residues 203-279 alleviates the PDZ-inhibition, allowing cleavage of intact RseA. {ECO 0000269|PubMed 11750129, ECO 0000269|PubMed 14633997, ECO 0000269|PubMed 18945679, ECO 0000269|PubMed 19706448, ECO 0000269|PubMed 23016873}. # ENZYME REGULATION Inhibited by Zn(2+) chelator 1,10- phenanthroline. {ECO:0000269|PubMed 21810987}. # EcoGene EG12436 rseP # FUNCTION RSEP_ECOLI A site-2 regulated intramembrane protease (S2P) that cleaves the peptide bond between 'Ala-108' and 'Cys-109' in the transmembrane region of RseA. Part of a regulated intramembrane proteolysis (RIP) cascade. Acts on DegS-cleaved RseA to release the cytoplasmic domain of RseA, residue "Val-148" of RseA may be required for this. This provides the cell with sigma-E (RpoE) activity through the proteolysis of RseA. Can also cleave sequences in transmembrane regions of other proteins (such as LacY) as well as liberated signal peptides of beta-lactamase, OmpF, LivK, SecM, PhoA, LivJ, OmpC, Lpp and TorA, probably within the membrane. {ECO 0000269|PubMed 12183368, ECO 0000269|PubMed 12183369, ECO 0000269|PubMed 15496982, ECO 0000269|PubMed 18268014, ECO 0000269|PubMed 18945679, ECO 0000269|PubMed 21810987}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoliWiki. # GO_function GO:0004222 metalloendopeptidase activity; IDA:EcoCyc. # GO_function GO:0043856 anti-sigma factor antagonist activity; IMP:EcoCyc. # GO_function GO:0045152 antisigma factor binding; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0000988 transcription factor activity, protein binding # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0043167 ion binding # Gene3D 2.30.42.10 -; 2. # INDUCTION Part of the sigma-E regulon. Also has a primary sigma- 70 factor promoter. {ECO:0000269|PubMed 11274153}. # InterPro IPR001478 PDZ # InterPro IPR004387 Pept_M50_Zn # InterPro IPR008915 Peptidase_M50 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # KEGG_Pathway ko04112 Cell cycle - Caulobacter # MISCELLANEOUS RSEP_ECOLI Regulated intramembrane proteolysis (RIP) occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. A membrane-spanning regulatory substrate protein is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P, this enzyme), while cytoplasmic proteases finish degrading the regulatory protein, liberating the effector protein. # Organism RSEP_ECOLI Escherichia coli (strain K12) # PATRIC 32115463 VBIEscCol129921_0183 # PDB 2ZPL X-ray; 1.70 A; A/B/C=127-221 # PDB 2ZPM X-ray; 0.98 A; A=222-309 # PDB 3ID1 X-ray; 1.67 A; A=127-220 # PDB 3ID2 X-ray; 3.09 A; A/B=222-309 # PDB 3ID3 X-ray; 2.01 A; A/B=222-309 # PDB 3ID4 X-ray; 1.60 A; A=222-307 # PIR H64741 H64741 # PROSITE PS00142 ZINC_PROTEASE # PROSITE PS50106 PDZ # Pfam PF00595 PDZ # Pfam PF02163 Peptidase_M50 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RSEP_ECOLI Regulator of sigma-E protease RseP # RefSeq NP_414718 NC_000913.3 # RefSeq WP_001295561 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase M50B family. {ECO 0000305}. # SIMILARITY Contains 2 PDZ (DHR) domains. {ECO:0000255|PROSITE- ProRule PRU00143}. # SMART SM00228 PDZ; 2 # SUBCELLULAR LOCATION RSEP_ECOLI Cell inner membrane {ECO 0000269|PubMed 11689431, ECO 0000269|PubMed 11750129, ECO 0000269|PubMed 11867724, ECO 0000269|PubMed 15919996}; Multi- pass membrane protein {ECO 0000269|PubMed 11689431, ECO 0000269|PubMed 11750129, ECO 0000269|PubMed 11867724, ECO 0000269|PubMed 15919996}. # SUBUNIT RSEP_ECOLI Interacts with RseA; the third transmembrane domain can be cross-linked to the transmembrane domain of RseA. {ECO 0000269|PubMed 14633997, ECO 0000269|PubMed 18268014}. # SUPFAM SSF50156 SSF50156; 2 # TIGRFAMs TIGR00054 TIGR00054 # eggNOG COG0750 LUCA # eggNOG ENOG4105DZP Bacteria BLAST swissprot:RSEP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RSEP_ECOLI BioCyc ECOL316407:JW0171-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0171-MONOMER BioCyc EcoCyc:EG12436-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12436-MONOMER COG COG0750 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0750 DIP DIP-48061N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48061N DOI 10.1016/S0378-1119(01)00823-X http://dx.doi.org/10.1016/S0378-1119(01)00823-X DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/sj.emboj.7600449 http://dx.doi.org/10.1038/sj.emboj.7600449 DOI 10.1073/pnas.052018199 http://dx.doi.org/10.1073/pnas.052018199 DOI 10.1073/pnas.0903289106 http://dx.doi.org/10.1073/pnas.0903289106 DOI 10.1073/pnas.1108376108 http://dx.doi.org/10.1073/pnas.1108376108 DOI 10.1074/jbc.M100464200 http://dx.doi.org/10.1074/jbc.M100464200 DOI 10.1074/jbc.M709984200 http://dx.doi.org/10.1074/jbc.M709984200 DOI 10.1074/jbc.M806603200 http://dx.doi.org/10.1074/jbc.M806603200 DOI 10.1093/emboj/20.21.5908 http://dx.doi.org/10.1093/emboj/20.21.5908 DOI 10.1093/emboj/cdg602 http://dx.doi.org/10.1093/emboj/cdg602 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1101/gad.1002302 http://dx.doi.org/10.1101/gad.1002302 DOI 10.1101/gad.1008902 http://dx.doi.org/10.1101/gad.1008902 DOI 10.1111/mmi.12053 http://dx.doi.org/10.1111/mmi.12053 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.24.- http://www.genome.jp/dbget-bin/www_bget?EC:3.4.24.- EMBL AF407012 http://www.ebi.ac.uk/ena/data/view/AF407012 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M11330 http://www.ebi.ac.uk/ena/data/view/M11330 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 ENZYME 3.4.24.- http://enzyme.expasy.org/EC/3.4.24.- EchoBASE EB2331 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2331 EcoGene EG12436 http://www.ecogene.org/geneInfo.php?eg_id=EG12436 EnsemblBacteria AAC73287 http://www.ensemblgenomes.org/id/AAC73287 EnsemblBacteria AAC73287 http://www.ensemblgenomes.org/id/AAC73287 EnsemblBacteria BAA77851 http://www.ensemblgenomes.org/id/BAA77851 EnsemblBacteria BAA77851 http://www.ensemblgenomes.org/id/BAA77851 EnsemblBacteria BAA77851 http://www.ensemblgenomes.org/id/BAA77851 EnsemblBacteria b0176 http://www.ensemblgenomes.org/id/b0176 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0004222 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004222 GO_function GO:0043856 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043856 GO_function GO:0045152 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045152 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0000988 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000988 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 2.30.42.10 http://www.cathdb.info/version/latest/superfamily/2.30.42.10 GeneID 944871 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944871 HOGENOM HOG000006281 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006281&db=HOGENOM6 InParanoid P0AEH1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEH1 IntAct P0AEH1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEH1* IntEnz 3.4.24 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.24 InterPro IPR001478 http://www.ebi.ac.uk/interpro/entry/IPR001478 InterPro IPR004387 http://www.ebi.ac.uk/interpro/entry/IPR004387 InterPro IPR008915 http://www.ebi.ac.uk/interpro/entry/IPR008915 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW0171 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0171 KEGG_Gene eco:b0176 http://www.genome.jp/dbget-bin/www_bget?eco:b0176 KEGG_Orthology KO:K11749 http://www.genome.jp/dbget-bin/www_bget?KO:K11749 KEGG_Pathway ko04112 http://www.genome.jp/kegg-bin/show_pathway?ko04112 OMA QMIVGKR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QMIVGKR PDB 2ZPL http://www.ebi.ac.uk/pdbe-srv/view/entry/2ZPL PDB 2ZPM http://www.ebi.ac.uk/pdbe-srv/view/entry/2ZPM PDB 3ID1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3ID1 PDB 3ID2 http://www.ebi.ac.uk/pdbe-srv/view/entry/3ID2 PDB 3ID3 http://www.ebi.ac.uk/pdbe-srv/view/entry/3ID3 PDB 3ID4 http://www.ebi.ac.uk/pdbe-srv/view/entry/3ID4 PDBsum 2ZPL http://www.ebi.ac.uk/pdbsum/2ZPL PDBsum 2ZPM http://www.ebi.ac.uk/pdbsum/2ZPM PDBsum 3ID1 http://www.ebi.ac.uk/pdbsum/3ID1 PDBsum 3ID2 http://www.ebi.ac.uk/pdbsum/3ID2 PDBsum 3ID3 http://www.ebi.ac.uk/pdbsum/3ID3 PDBsum 3ID4 http://www.ebi.ac.uk/pdbsum/3ID4 PROSITE PS00142 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00142 PROSITE PS50106 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50106 PSORT swissprot:RSEP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RSEP_ECOLI PSORT-B swissprot:RSEP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RSEP_ECOLI PSORT2 swissprot:RSEP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RSEP_ECOLI Pfam PF00595 http://pfam.xfam.org/family/PF00595 Pfam PF02163 http://pfam.xfam.org/family/PF02163 Phobius swissprot:RSEP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RSEP_ECOLI PhylomeDB P0AEH1 http://phylomedb.org/?seqid=P0AEH1 ProteinModelPortal P0AEH1 http://www.proteinmodelportal.org/query/uniprot/P0AEH1 PubMed 11274153 http://www.ncbi.nlm.nih.gov/pubmed/11274153 PubMed 11689431 http://www.ncbi.nlm.nih.gov/pubmed/11689431 PubMed 11750129 http://www.ncbi.nlm.nih.gov/pubmed/11750129 PubMed 11867724 http://www.ncbi.nlm.nih.gov/pubmed/11867724 PubMed 12183368 http://www.ncbi.nlm.nih.gov/pubmed/12183368 PubMed 12183369 http://www.ncbi.nlm.nih.gov/pubmed/12183369 PubMed 14633997 http://www.ncbi.nlm.nih.gov/pubmed/14633997 PubMed 15496982 http://www.ncbi.nlm.nih.gov/pubmed/15496982 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18268014 http://www.ncbi.nlm.nih.gov/pubmed/18268014 PubMed 18945679 http://www.ncbi.nlm.nih.gov/pubmed/18945679 PubMed 19706448 http://www.ncbi.nlm.nih.gov/pubmed/19706448 PubMed 21810987 http://www.ncbi.nlm.nih.gov/pubmed/21810987 PubMed 23016873 http://www.ncbi.nlm.nih.gov/pubmed/23016873 PubMed 2995358 http://www.ncbi.nlm.nih.gov/pubmed/2995358 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414718 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414718 RefSeq WP_001295561 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295561 SMART SM00228 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00228 SMR P0AEH1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEH1 STRING 511145.b0176 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0176&targetmode=cogs STRING COG0750 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0750&targetmode=cogs SUPFAM SSF50156 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50156 TIGRFAMs TIGR00054 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00054 UniProtKB RSEP_ECOLI http://www.uniprot.org/uniprot/RSEP_ECOLI UniProtKB-AC P0AEH1 http://www.uniprot.org/uniprot/P0AEH1 charge swissprot:RSEP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RSEP_ECOLI eggNOG COG0750 http://eggnogapi.embl.de/nog_data/html/tree/COG0750 eggNOG ENOG4105DZP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DZP epestfind swissprot:RSEP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RSEP_ECOLI garnier swissprot:RSEP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RSEP_ECOLI helixturnhelix swissprot:RSEP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RSEP_ECOLI hmoment swissprot:RSEP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RSEP_ECOLI iep swissprot:RSEP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RSEP_ECOLI inforesidue swissprot:RSEP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RSEP_ECOLI octanol swissprot:RSEP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RSEP_ECOLI pepcoil swissprot:RSEP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RSEP_ECOLI pepdigest swissprot:RSEP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RSEP_ECOLI pepinfo swissprot:RSEP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RSEP_ECOLI pepnet swissprot:RSEP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RSEP_ECOLI pepstats swissprot:RSEP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RSEP_ECOLI pepwheel swissprot:RSEP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RSEP_ECOLI pepwindow swissprot:RSEP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RSEP_ECOLI sigcleave swissprot:RSEP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RSEP_ECOLI ## Database ID URL or Descriptions # BioGrid 4263119 7 # EcoGene EG13489 yeaC # IntAct P76231 2 # InterPro IPR009749 DUF1315 # Organism YEAC_ECOLI Escherichia coli (strain K12) # PATRIC 32118865 VBIEscCol129921_1850 # PIR A64938 A64938 # Pfam PF07023 DUF1315 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEAC_ECOLI Uncharacterized protein YeaC # RefSeq NP_416291 NC_000913.3 # RefSeq WP_001300415 NZ_LN832404.1 # eggNOG COG3139 LUCA # eggNOG ENOG4105VUT Bacteria BLAST swissprot:YEAC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEAC_ECOLI BioCyc ECOL316407:JW1766-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1766-MONOMER BioCyc EcoCyc:G6964-MONOMER http://biocyc.org/getid?id=EcoCyc:G6964-MONOMER COG COG3139 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3139 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3262 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3262 EcoGene EG13489 http://www.ecogene.org/geneInfo.php?eg_id=EG13489 EnsemblBacteria AAC74847 http://www.ensemblgenomes.org/id/AAC74847 EnsemblBacteria AAC74847 http://www.ensemblgenomes.org/id/AAC74847 EnsemblBacteria BAE76525 http://www.ensemblgenomes.org/id/BAE76525 EnsemblBacteria BAE76525 http://www.ensemblgenomes.org/id/BAE76525 EnsemblBacteria BAE76525 http://www.ensemblgenomes.org/id/BAE76525 EnsemblBacteria b1777 http://www.ensemblgenomes.org/id/b1777 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947074 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947074 HOGENOM HOG000282002 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000282002&db=HOGENOM6 InParanoid P76231 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76231 IntAct P76231 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76231* InterPro IPR009749 http://www.ebi.ac.uk/interpro/entry/IPR009749 KEGG_Gene ecj:JW1766 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1766 KEGG_Gene eco:b1777 http://www.genome.jp/dbget-bin/www_bget?eco:b1777 KEGG_Orthology KO:K09916 http://www.genome.jp/dbget-bin/www_bget?KO:K09916 OMA HMTIGTD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HMTIGTD PSORT swissprot:YEAC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEAC_ECOLI PSORT-B swissprot:YEAC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEAC_ECOLI PSORT2 swissprot:YEAC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEAC_ECOLI Pfam PF07023 http://pfam.xfam.org/family/PF07023 Phobius swissprot:YEAC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEAC_ECOLI ProteinModelPortal P76231 http://www.proteinmodelportal.org/query/uniprot/P76231 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416291 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416291 RefSeq WP_001300415 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300415 STRING 511145.b1777 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1777&targetmode=cogs STRING COG3139 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3139&targetmode=cogs UniProtKB YEAC_ECOLI http://www.uniprot.org/uniprot/YEAC_ECOLI UniProtKB-AC P76231 http://www.uniprot.org/uniprot/P76231 charge swissprot:YEAC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEAC_ECOLI eggNOG COG3139 http://eggnogapi.embl.de/nog_data/html/tree/COG3139 eggNOG ENOG4105VUT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VUT epestfind swissprot:YEAC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEAC_ECOLI garnier swissprot:YEAC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEAC_ECOLI helixturnhelix swissprot:YEAC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEAC_ECOLI hmoment swissprot:YEAC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEAC_ECOLI iep swissprot:YEAC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEAC_ECOLI inforesidue swissprot:YEAC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEAC_ECOLI octanol swissprot:YEAC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEAC_ECOLI pepcoil swissprot:YEAC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEAC_ECOLI pepdigest swissprot:YEAC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEAC_ECOLI pepinfo swissprot:YEAC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEAC_ECOLI pepnet swissprot:YEAC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEAC_ECOLI pepstats swissprot:YEAC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEAC_ECOLI pepwheel swissprot:YEAC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEAC_ECOLI pepwindow swissprot:YEAC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEAC_ECOLI sigcleave swissprot:YEAC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEAC_ECOLI ## Database ID URL or Descriptions # BioGrid 4263367 24 # COFACTOR NUDL_ECOLI Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000255|HAMAP-Rule MF_01592}; Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_01592}; # EcoGene EG12693 nudL # FUNCTION NUDL_ECOLI Probably mediates the hydrolysis of some nucleoside diphosphate derivatives. {ECO 0000255|HAMAP-Rule MF_01592}. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IDA:EcoCyc. # GO_function GO:0030145 manganese ion binding; IEA:UniProtKB-HAMAP. # GO_process GO:0009132 nucleoside diphosphate metabolic process; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.90.79.10 -; 1. # HAMAP MF_01592 Nudix_NudL # IntAct P43337 5 # InterPro IPR000059 NUDIX_hydrolase_NudL_CS # InterPro IPR000086 NUDIX_hydrolase_dom # InterPro IPR015797 NUDIX_hydrolase_dom-like # InterPro IPR023735 Nudix_NudL # Organism NUDL_ECOLI Escherichia coli (strain K12) # PATRIC 32118945 VBIEscCol129921_1890 # PIR E64942 E64942 # PROSITE PS01293 NUDIX_COA # PROSITE PS51462 NUDIX # Pfam PF00293 NUDIX # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Uncharacterized Nudix hydrolase NudL {ECO:0000255|HAMAP-Rule MF_01592} # RefSeq NP_416327 NC_000913.3 # RefSeq WP_000456715 NZ_LN832404.1 # SIMILARITY Belongs to the Nudix hydrolase family. PCD1 subfamily. {ECO:0000255|HAMAP-Rule MF_01592}. # SIMILARITY Contains 1 nudix hydrolase domain. {ECO:0000255|HAMAP- Rule MF_01592}. # SUPFAM SSF55811 SSF55811 # eggNOG COG0494 LUCA # eggNOG ENOG4105P8F Bacteria BLAST swissprot:NUDL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NUDL_ECOLI BioCyc ECOL316407:JW1802-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1802-MONOMER BioCyc EcoCyc:EG12693-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12693-MONOMER BioCyc MetaCyc:EG12693-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12693-MONOMER DIP DIP-11783N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11783N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.1.- {ECO:0000255|HAMAP-Rule:MF_01592} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.1.- {ECO:0000255|HAMAP-Rule:MF_01592} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K02673 http://www.ebi.ac.uk/ena/data/view/K02673 EMBL M28695 http://www.ebi.ac.uk/ena/data/view/M28695 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.6.1.- {ECO:0000255|HAMAP-Rule:MF_01592} http://enzyme.expasy.org/EC/3.6.1.- {ECO:0000255|HAMAP-Rule:MF_01592} EchoBASE EB2556 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2556 EcoGene EG12693 http://www.ecogene.org/geneInfo.php?eg_id=EG12693 EnsemblBacteria AAC74883 http://www.ensemblgenomes.org/id/AAC74883 EnsemblBacteria AAC74883 http://www.ensemblgenomes.org/id/AAC74883 EnsemblBacteria BAA15620 http://www.ensemblgenomes.org/id/BAA15620 EnsemblBacteria BAA15620 http://www.ensemblgenomes.org/id/BAA15620 EnsemblBacteria BAA15620 http://www.ensemblgenomes.org/id/BAA15620 EnsemblBacteria b1813 http://www.ensemblgenomes.org/id/b1813 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0016818 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016818 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_process GO:0009132 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009132 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.90.79.10 http://www.cathdb.info/version/latest/superfamily/3.90.79.10 GeneID 946330 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946330 HAMAP MF_01592 http://hamap.expasy.org/unirule/MF_01592 HOGENOM HOG000250455 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000250455&db=HOGENOM6 InParanoid P43337 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P43337 IntAct P43337 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P43337* IntEnz 3.6.1.- {ECO:0000255|HAMAP-Rule:MF_01592} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.1.- {ECO:0000255|HAMAP-Rule:MF_01592} InterPro IPR000059 http://www.ebi.ac.uk/interpro/entry/IPR000059 InterPro IPR000086 http://www.ebi.ac.uk/interpro/entry/IPR000086 InterPro IPR015797 http://www.ebi.ac.uk/interpro/entry/IPR015797 InterPro IPR023735 http://www.ebi.ac.uk/interpro/entry/IPR023735 KEGG_Gene ecj:JW1802 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1802 KEGG_Gene eco:b1813 http://www.genome.jp/dbget-bin/www_bget?eco:b1813 MINT MINT-1232423 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1232423 OMA WRDHGDH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WRDHGDH PROSITE PS01293 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01293 PROSITE PS51462 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51462 PSORT swissprot:NUDL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NUDL_ECOLI PSORT-B swissprot:NUDL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NUDL_ECOLI PSORT2 swissprot:NUDL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NUDL_ECOLI Pfam PF00293 http://pfam.xfam.org/family/PF00293 Phobius swissprot:NUDL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NUDL_ECOLI PhylomeDB P43337 http://phylomedb.org/?seqid=P43337 ProteinModelPortal P43337 http://www.proteinmodelportal.org/query/uniprot/P43337 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2504697 http://www.ncbi.nlm.nih.gov/pubmed/2504697 PubMed 6330050 http://www.ncbi.nlm.nih.gov/pubmed/6330050 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416327 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416327 RefSeq WP_000456715 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000456715 SMR P43337 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P43337 STRING 511145.b1813 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1813&targetmode=cogs SUPFAM SSF55811 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55811 UniProtKB NUDL_ECOLI http://www.uniprot.org/uniprot/NUDL_ECOLI UniProtKB-AC P43337 http://www.uniprot.org/uniprot/P43337 charge swissprot:NUDL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NUDL_ECOLI eggNOG COG0494 http://eggnogapi.embl.de/nog_data/html/tree/COG0494 eggNOG ENOG4105P8F http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105P8F epestfind swissprot:NUDL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NUDL_ECOLI garnier swissprot:NUDL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NUDL_ECOLI helixturnhelix swissprot:NUDL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NUDL_ECOLI hmoment swissprot:NUDL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NUDL_ECOLI iep swissprot:NUDL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NUDL_ECOLI inforesidue swissprot:NUDL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NUDL_ECOLI octanol swissprot:NUDL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NUDL_ECOLI pepcoil swissprot:NUDL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NUDL_ECOLI pepdigest swissprot:NUDL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NUDL_ECOLI pepinfo swissprot:NUDL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NUDL_ECOLI pepnet swissprot:NUDL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NUDL_ECOLI pepstats swissprot:NUDL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NUDL_ECOLI pepwheel swissprot:NUDL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NUDL_ECOLI pepwindow swissprot:NUDL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NUDL_ECOLI sigcleave swissprot:NUDL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NUDL_ECOLI ## Database ID URL or Descriptions # AltName HELD_ECOLI 75 kDa helicase # BioGrid 4263362 127 # CATALYTIC ACTIVITY HELD_ECOLI ATP + H(2)O = ADP + phosphate. # EcoGene EG10426 helD # FUNCTION HELD_ECOLI Helicase IV catalyzes the unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand in a reaction that is dependent upon the hydrolysis of ATP. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0033202 DNA helicase complex; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0043140 ATP-dependent 3'-5' DNA helicase activity; IDA:EcoCyc. # GO_process GO:0006310 DNA recombination; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004386 helicase activity # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # Gene3D 3.40.50.300 -; 3. # INTERACTION HELD_ECOLI P00936 cyaA; NbExp=3; IntAct=EBI-551473, EBI-1116685; P0CE47 tufA; NbExp=2; IntAct=EBI-551473, EBI-301077; # IntAct P15038 34 # InterPro IPR000212 DNA_helicase_UvrD/REP # InterPro IPR014016 UvrD-like_ATP-bd # InterPro IPR014017 DNA_helicase_UvrD-like_C # InterPro IPR022161 Helicase_IV_N # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # Organism HELD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11070 PTHR11070 # PATRIC 32117143 VBIEscCol129921_0996 # PIR A64837 HJECD4 # PROSITE PS51198 UVRD_HELICASE_ATP_BIND # Pfam PF00580 UvrD-helicase # Pfam PF12462 Helicase_IV_N # Pfam PF13361 UvrD_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HELD_ECOLI Helicase IV # RefSeq NP_415482 NC_000913.3 # RefSeq WP_001295354 NZ_LN832404.1 # SIMILARITY Belongs to the helicase family. UvrD subfamily. {ECO 0000305}. # SIMILARITY Contains 1 uvrD-like helicase ATP-binding domain. {ECO:0000255|PROSITE-ProRule PRU00560}. # SUPFAM SSF52540 SSF52540; 2 # eggNOG COG0210 LUCA # eggNOG ENOG41088T4 Bacteria BLAST swissprot:HELD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HELD_ECOLI BioCyc ECOL316407:JW0945-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0945-MONOMER BioCyc EcoCyc:EG10426-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10426-MONOMER COG COG0210 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0210 DIP DIP-9876N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9876N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.4.12 http://www.genome.jp/dbget-bin/www_bget?EC:3.6.4.12 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J04726 http://www.ebi.ac.uk/ena/data/view/J04726 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.6.4.12 http://enzyme.expasy.org/EC/3.6.4.12 EchoBASE EB0421 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0421 EcoGene EG10426 http://www.ecogene.org/geneInfo.php?eg_id=EG10426 EnsemblBacteria AAC74048 http://www.ensemblgenomes.org/id/AAC74048 EnsemblBacteria AAC74048 http://www.ensemblgenomes.org/id/AAC74048 EnsemblBacteria BAA35727 http://www.ensemblgenomes.org/id/BAA35727 EnsemblBacteria BAA35727 http://www.ensemblgenomes.org/id/BAA35727 EnsemblBacteria BAA35727 http://www.ensemblgenomes.org/id/BAA35727 EnsemblBacteria b0962 http://www.ensemblgenomes.org/id/b0962 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0033202 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033202 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0043140 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043140 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004386 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 946227 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946227 HOGENOM HOG000118816 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118816&db=HOGENOM6 InParanoid P15038 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P15038 IntAct P15038 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P15038* IntEnz 3.6.4.12 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.4.12 InterPro IPR000212 http://www.ebi.ac.uk/interpro/entry/IPR000212 InterPro IPR014016 http://www.ebi.ac.uk/interpro/entry/IPR014016 InterPro IPR014017 http://www.ebi.ac.uk/interpro/entry/IPR014017 InterPro IPR022161 http://www.ebi.ac.uk/interpro/entry/IPR022161 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW0945 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0945 KEGG_Gene eco:b0962 http://www.genome.jp/dbget-bin/www_bget?eco:b0962 KEGG_Orthology KO:K03658 http://www.genome.jp/dbget-bin/www_bget?KO:K03658 MINT MINT-1226516 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1226516 OMA HYFGEGD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HYFGEGD PANTHER PTHR11070 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11070 PROSITE PS51198 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51198 PSORT swissprot:HELD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HELD_ECOLI PSORT-B swissprot:HELD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HELD_ECOLI PSORT2 swissprot:HELD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HELD_ECOLI Pfam PF00580 http://pfam.xfam.org/family/PF00580 Pfam PF12462 http://pfam.xfam.org/family/PF12462 Pfam PF13361 http://pfam.xfam.org/family/PF13361 Phobius swissprot:HELD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HELD_ECOLI PhylomeDB P15038 http://phylomedb.org/?seqid=P15038 ProteinModelPortal P15038 http://www.proteinmodelportal.org/query/uniprot/P15038 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2542273 http://www.ncbi.nlm.nih.gov/pubmed/2542273 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415482 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415482 RefSeq WP_001295354 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295354 SMR P15038 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P15038 STRING 511145.b0962 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0962&targetmode=cogs STRING COG0210 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0210&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB HELD_ECOLI http://www.uniprot.org/uniprot/HELD_ECOLI UniProtKB-AC P15038 http://www.uniprot.org/uniprot/P15038 charge swissprot:HELD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HELD_ECOLI eggNOG COG0210 http://eggnogapi.embl.de/nog_data/html/tree/COG0210 eggNOG ENOG41088T4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41088T4 epestfind swissprot:HELD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HELD_ECOLI garnier swissprot:HELD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HELD_ECOLI helixturnhelix swissprot:HELD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HELD_ECOLI hmoment swissprot:HELD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HELD_ECOLI iep swissprot:HELD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HELD_ECOLI inforesidue swissprot:HELD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HELD_ECOLI octanol swissprot:HELD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HELD_ECOLI pepcoil swissprot:HELD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HELD_ECOLI pepdigest swissprot:HELD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HELD_ECOLI pepinfo swissprot:HELD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HELD_ECOLI pepnet swissprot:HELD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HELD_ECOLI pepstats swissprot:HELD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HELD_ECOLI pepwheel swissprot:HELD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HELD_ECOLI pepwindow swissprot:HELD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HELD_ECOLI sigcleave swissprot:HELD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HELD_ECOLI ## Database ID URL or Descriptions # AltName SGBH_ECOLI 3-dehydro-L-gulonate-6-phosphate decarboxylase # BioGrid 4259346 191 # CATALYTIC ACTIVITY SGBH_ECOLI 3-dehydro-L-gulonate 6-phosphate = L-xylulose 5-phosphate + CO(2). # COFACTOR SGBH_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250}; Note=Binds 1 Mg(2+) ion per subunit. {ECO 0000250}; # EcoGene EG12285 sgbH # FUNCTION SGBH_ECOLI Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P. May be involved in the utilization of 2,3- diketo-L-gulonate. {ECO 0000269|PubMed 11741871}. # GO_function GO:0004590 orotidine-5'-phosphate decarboxylase activity; IEA:InterPro. # GO_function GO:0033982 3-dehydro-L-gulonate-6-phosphate decarboxylase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro. # GO_process GO:0016052 carbohydrate catabolic process; IEP:EcoCyc. # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.70 -; 1. # IntAct P37678 3 # InterPro IPR001754 OMPdeCOase_dom # InterPro IPR011060 RibuloseP-bd_barrel # InterPro IPR013785 Aldolase_TIM # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00040 Pentose and glucuronate interconversions # Organism SGBH_ECOLI Escherichia coli (strain K12) # PATRIC 32122638 VBIEscCol129921_3696 # PIR S47802 S47802 # Pfam PF00215 OMPdecase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SGBH_ECOLI 3-keto-L-gulonate-6-phosphate decarboxylase SgbH # RefSeq NP_418038 NC_000913.3 # RefSeq WP_000089481 NZ_LN832404.1 # SIMILARITY Belongs to the HPS/KGPDC family. KGPDC subfamily. {ECO 0000305}. # SMART SM00934 OMPdecase # SUBUNIT Homodimer. {ECO 0000250}. # SUPFAM SSF51366 SSF51366 # eggNOG COG0269 LUCA # eggNOG ENOG4105H6Q Bacteria BLAST swissprot:SGBH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SGBH_ECOLI BioCyc ECOL316407:JW3553-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3553-MONOMER BioCyc EcoCyc:EG12285-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12285-MONOMER BioCyc MetaCyc:EG12285-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12285-MONOMER COG COG0269 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0269 DIP DIP-10873N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10873N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1099/00221287-143-8-2519 http://dx.doi.org/10.1099/00221287-143-8-2519 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.1.302-306.2002 http://dx.doi.org/10.1128/JB.184.1.302-306.2002 EC_number EC:4.1.1.85 http://www.genome.jp/dbget-bin/www_bget?EC:4.1.1.85 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 4.1.1.85 http://enzyme.expasy.org/EC/4.1.1.85 EchoBASE EB2193 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2193 EcoGene EG12285 http://www.ecogene.org/geneInfo.php?eg_id=EG12285 EnsemblBacteria AAC76605 http://www.ensemblgenomes.org/id/AAC76605 EnsemblBacteria AAC76605 http://www.ensemblgenomes.org/id/AAC76605 EnsemblBacteria BAE77712 http://www.ensemblgenomes.org/id/BAE77712 EnsemblBacteria BAE77712 http://www.ensemblgenomes.org/id/BAE77712 EnsemblBacteria BAE77712 http://www.ensemblgenomes.org/id/BAE77712 EnsemblBacteria b3581 http://www.ensemblgenomes.org/id/b3581 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004590 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004590 GO_function GO:0033982 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033982 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006207 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006207 GO_process GO:0016052 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016052 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 948098 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948098 HOGENOM HOG000226068 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000226068&db=HOGENOM6 InParanoid P37678 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37678 IntAct P37678 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37678* IntEnz 4.1.1.85 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.1.85 InterPro IPR001754 http://www.ebi.ac.uk/interpro/entry/IPR001754 InterPro IPR011060 http://www.ebi.ac.uk/interpro/entry/IPR011060 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3553 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3553 KEGG_Gene eco:b3581 http://www.genome.jp/dbget-bin/www_bget?eco:b3581 KEGG_Orthology KO:K03081 http://www.genome.jp/dbget-bin/www_bget?KO:K03081 KEGG_Pathway ko00040 http://www.genome.jp/kegg-bin/show_pathway?ko00040 KEGG_Reaction rn:R07125 http://www.genome.jp/dbget-bin/www_bget?rn:R07125 MINT MINT-1281843 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1281843 OMA CISAGIQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CISAGIQ PSORT swissprot:SGBH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SGBH_ECOLI PSORT-B swissprot:SGBH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SGBH_ECOLI PSORT2 swissprot:SGBH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SGBH_ECOLI Pfam PF00215 http://pfam.xfam.org/family/PF00215 Phobius swissprot:SGBH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SGBH_ECOLI PhylomeDB P37678 http://phylomedb.org/?seqid=P37678 ProteinModelPortal P37678 http://www.proteinmodelportal.org/query/uniprot/P37678 PubMed 11741871 http://www.ncbi.nlm.nih.gov/pubmed/11741871 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9274005 http://www.ncbi.nlm.nih.gov/pubmed/9274005 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418038 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418038 RefSeq WP_000089481 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000089481 SMART SM00934 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00934 SMR P37678 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37678 STRING 511145.b3581 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3581&targetmode=cogs STRING COG0269 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0269&targetmode=cogs SUPFAM SSF51366 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51366 UniProtKB SGBH_ECOLI http://www.uniprot.org/uniprot/SGBH_ECOLI UniProtKB-AC P37678 http://www.uniprot.org/uniprot/P37678 charge swissprot:SGBH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SGBH_ECOLI eggNOG COG0269 http://eggnogapi.embl.de/nog_data/html/tree/COG0269 eggNOG ENOG4105H6Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105H6Q epestfind swissprot:SGBH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SGBH_ECOLI garnier swissprot:SGBH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SGBH_ECOLI helixturnhelix swissprot:SGBH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SGBH_ECOLI hmoment swissprot:SGBH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SGBH_ECOLI iep swissprot:SGBH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SGBH_ECOLI inforesidue swissprot:SGBH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SGBH_ECOLI octanol swissprot:SGBH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SGBH_ECOLI pepcoil swissprot:SGBH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SGBH_ECOLI pepdigest swissprot:SGBH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SGBH_ECOLI pepinfo swissprot:SGBH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SGBH_ECOLI pepnet swissprot:SGBH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SGBH_ECOLI pepstats swissprot:SGBH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SGBH_ECOLI pepwheel swissprot:SGBH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SGBH_ECOLI pepwindow swissprot:SGBH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SGBH_ECOLI sigcleave swissprot:SGBH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SGBH_ECOLI ## Database ID URL or Descriptions # BioGrid 4259741 9 # DISRUPTION PHENOTYPE Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain. {ECO:0000269|PubMed 20345943}. # EcoGene EG12327 yadM # FUNCTION YADM_ECOLI Part of the yadCKLM-htrE-yadVN fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. {ECO 0000269|PubMed 20345943}. # GO_component GO:0009289 pilus; IEA:UniProtKB-SubCell. # GO_process GO:0007155 cell adhesion; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0007155 cell adhesion # Gene3D 2.60.40.1090 -; 1. # INDUCTION Repressed by H-NS. {ECO:0000269|PubMed 20345943}. # InterPro IPR000259 Adhesion_dom_fimbrial # InterPro IPR008966 Adhesion_dom # MISCELLANEOUS The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed. {ECO:0000305|PubMed 20345943}. # Organism YADM_ECOLI Escherichia coli (strain K12) # PATRIC 32115381 VBIEscCol129921_0142 # Pfam PF00419 Fimbrial # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YADM_ECOLI Uncharacterized fimbrial-like protein YadM # RefSeq NP_414680 NC_000913.3 # RefSeq WP_000598300 NZ_LN832404.1 # SIMILARITY Belongs to the fimbrial protein family. {ECO 0000305}. # SUBCELLULAR LOCATION YADM_ECOLI Fimbrium {ECO 0000305}. # SUPFAM SSF49401 SSF49401 # eggNOG ENOG4108XEY Bacteria # eggNOG ENOG410Y46X LUCA BLAST swissprot:YADM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YADM_ECOLI BioCyc ECOL316407:JW0134-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0134-MONOMER BioCyc EcoCyc:EG12327-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12327-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1111/j.1462-2920.2010.02202.x http://dx.doi.org/10.1111/j.1462-2920.2010.02202.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2231 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2231 EcoGene EG12327 http://www.ecogene.org/geneInfo.php?eg_id=EG12327 EnsemblBacteria AAC73249 http://www.ensemblgenomes.org/id/AAC73249 EnsemblBacteria AAC73249 http://www.ensemblgenomes.org/id/AAC73249 EnsemblBacteria BAB96715 http://www.ensemblgenomes.org/id/BAB96715 EnsemblBacteria BAB96715 http://www.ensemblgenomes.org/id/BAB96715 EnsemblBacteria BAB96715 http://www.ensemblgenomes.org/id/BAB96715 EnsemblBacteria b0138 http://www.ensemblgenomes.org/id/b0138 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009289 GO_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 Gene3D 2.60.40.1090 http://www.cathdb.info/version/latest/superfamily/2.60.40.1090 GeneID 944828 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944828 HOGENOM HOG000116900 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000116900&db=HOGENOM6 InterPro IPR000259 http://www.ebi.ac.uk/interpro/entry/IPR000259 InterPro IPR008966 http://www.ebi.ac.uk/interpro/entry/IPR008966 KEGG_Gene ecj:JW0134 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0134 KEGG_Gene eco:b0138 http://www.genome.jp/dbget-bin/www_bget?eco:b0138 OMA ANEVEMT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ANEVEMT PSORT swissprot:YADM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YADM_ECOLI PSORT-B swissprot:YADM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YADM_ECOLI PSORT2 swissprot:YADM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YADM_ECOLI Pfam PF00419 http://pfam.xfam.org/family/PF00419 Phobius swissprot:YADM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YADM_ECOLI ProteinModelPortal P37018 http://www.proteinmodelportal.org/query/uniprot/P37018 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20345943 http://www.ncbi.nlm.nih.gov/pubmed/20345943 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414680 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414680 RefSeq WP_000598300 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000598300 STRING 511145.b0138 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0138&targetmode=cogs SUPFAM SSF49401 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49401 UniProtKB YADM_ECOLI http://www.uniprot.org/uniprot/YADM_ECOLI UniProtKB-AC P37018 http://www.uniprot.org/uniprot/P37018 charge swissprot:YADM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YADM_ECOLI eggNOG ENOG4108XEY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108XEY eggNOG ENOG410Y46X http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y46X epestfind swissprot:YADM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YADM_ECOLI garnier swissprot:YADM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YADM_ECOLI helixturnhelix swissprot:YADM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YADM_ECOLI hmoment swissprot:YADM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YADM_ECOLI iep swissprot:YADM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YADM_ECOLI inforesidue swissprot:YADM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YADM_ECOLI octanol swissprot:YADM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YADM_ECOLI pepcoil swissprot:YADM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YADM_ECOLI pepdigest swissprot:YADM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YADM_ECOLI pepinfo swissprot:YADM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YADM_ECOLI pepnet swissprot:YADM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YADM_ECOLI pepstats swissprot:YADM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YADM_ECOLI pepwheel swissprot:YADM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YADM_ECOLI pepwindow swissprot:YADM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YADM_ECOLI sigcleave swissprot:YADM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YADM_ECOLI ## Database ID URL or Descriptions # BioGrid 4259776 11 # EcoGene EG13342 mmuP # FUNCTION MMUP_ECOLI Transporter for the intake of S-methylmethionine. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0000100 S-methylmethionine transmembrane transporter activity; IMP:EcoCyc. # GO_function GO:0015179 L-amino acid transmembrane transporter activity; IBA:GO_Central. # GO_function GO:0015297 antiporter activity; IBA:GO_Central. # GO_process GO:0009086 methionine biosynthetic process; IMP:EcoCyc. # GO_process GO:0015806 S-methylmethionine transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0006810 transport # GOslim_process GO:0009058 biosynthetic process # InterPro IPR002293 AA/rel_permease1 # InterPro IPR004840 Amoino_acid_permease_CS # InterPro IPR004841 AA-permease/SLC12A_dom # Organism MMUP_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11785 PTHR11785 # PATRIC 32115639 VBIEscCol129921_0263 # PIR D64751 D64751 # PIRSF PIRSF006060 AA_transporter # PROSITE PS00218 AMINO_ACID_PERMEASE_1 # Pfam PF00324 AA_permease # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MMUP_ECOLI Probable S-methylmethionine permease # RefSeq NP_414794 NC_000913.3 # RefSeq WP_001393629 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB08681.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family. {ECO 0000305}. # SUBCELLULAR LOCATION MMUP_ECOLI Cell inner membrane {ECO 0000305}; Multi- pass membrane protein {ECO 0000305}. # TCDB 2.A.3.1.10 the amino acid-polyamine-organocation (apc) family # eggNOG COG0833 LUCA # eggNOG ENOG4108IQI Bacteria BLAST swissprot:MMUP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MMUP_ECOLI BioCyc ECOL316407:JW5027-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5027-MONOMER BioCyc EcoCyc:B0260-MONOMER http://biocyc.org/getid?id=EcoCyc:B0260-MONOMER BioCyc MetaCyc:B0260-MONOMER http://biocyc.org/getid?id=MetaCyc:B0260-MONOMER COG COG0833 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0833 COG COG1113 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1113 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EchoBASE EB3126 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3126 EcoGene EG13342 http://www.ecogene.org/geneInfo.php?eg_id=EG13342 EnsemblBacteria AAC73363 http://www.ensemblgenomes.org/id/AAC73363 EnsemblBacteria AAC73363 http://www.ensemblgenomes.org/id/AAC73363 EnsemblBacteria BAA77928 http://www.ensemblgenomes.org/id/BAA77928 EnsemblBacteria BAA77928 http://www.ensemblgenomes.org/id/BAA77928 EnsemblBacteria BAA77928 http://www.ensemblgenomes.org/id/BAA77928 EnsemblBacteria b0260 http://www.ensemblgenomes.org/id/b0260 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0000100 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000100 GO_function GO:0015179 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015179 GO_function GO:0015297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015297 GO_process GO:0009086 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009086 GO_process GO:0015806 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015806 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 946284 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946284 HOGENOM HOG000261850 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261850&db=HOGENOM6 InParanoid Q47689 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q47689 InterPro IPR002293 http://www.ebi.ac.uk/interpro/entry/IPR002293 InterPro IPR004840 http://www.ebi.ac.uk/interpro/entry/IPR004840 InterPro IPR004841 http://www.ebi.ac.uk/interpro/entry/IPR004841 KEGG_Gene ecj:JW5027 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5027 KEGG_Gene eco:b0260 http://www.genome.jp/dbget-bin/www_bget?eco:b0260 KEGG_Orthology KO:K03293 http://www.genome.jp/dbget-bin/www_bget?KO:K03293 OMA CASHYVF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CASHYVF PANTHER PTHR11785 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11785 PROSITE PS00218 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00218 PSORT swissprot:MMUP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MMUP_ECOLI PSORT-B swissprot:MMUP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MMUP_ECOLI PSORT2 swissprot:MMUP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MMUP_ECOLI Pfam PF00324 http://pfam.xfam.org/family/PF00324 Phobius swissprot:MMUP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MMUP_ECOLI PhylomeDB Q47689 http://phylomedb.org/?seqid=Q47689 ProteinModelPortal Q47689 http://www.proteinmodelportal.org/query/uniprot/Q47689 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9882684 http://www.ncbi.nlm.nih.gov/pubmed/9882684 RefSeq NP_414794 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414794 RefSeq WP_001393629 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001393629 STRING 511145.b0260 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0260&targetmode=cogs STRING COG0833 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0833&targetmode=cogs STRING COG1113 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1113&targetmode=cogs TCDB 2.A.3.1.10 http://www.tcdb.org/search/result.php?tc=2.A.3.1.10 UniProtKB MMUP_ECOLI http://www.uniprot.org/uniprot/MMUP_ECOLI UniProtKB-AC Q47689 http://www.uniprot.org/uniprot/Q47689 charge swissprot:MMUP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MMUP_ECOLI eggNOG COG0833 http://eggnogapi.embl.de/nog_data/html/tree/COG0833 eggNOG ENOG4108IQI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108IQI epestfind swissprot:MMUP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MMUP_ECOLI garnier swissprot:MMUP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MMUP_ECOLI helixturnhelix swissprot:MMUP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MMUP_ECOLI hmoment swissprot:MMUP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MMUP_ECOLI iep swissprot:MMUP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MMUP_ECOLI inforesidue swissprot:MMUP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MMUP_ECOLI octanol swissprot:MMUP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MMUP_ECOLI pepcoil swissprot:MMUP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MMUP_ECOLI pepdigest swissprot:MMUP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MMUP_ECOLI pepinfo swissprot:MMUP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MMUP_ECOLI pepnet swissprot:MMUP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MMUP_ECOLI pepstats swissprot:MMUP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MMUP_ECOLI pepwheel swissprot:MMUP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MMUP_ECOLI pepwindow swissprot:MMUP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MMUP_ECOLI sigcleave swissprot:MMUP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MMUP_ECOLI ## Database ID URL or Descriptions # BioGrid 4260737 14 # COFACTOR YFEX_ECOLI Name=heme b; Xref=ChEBI CHEBI 60344; Evidence={ECO 0000269|PubMed 19564607}; Note=Binds 1 heme b (iron(II)-protoporphyrin IX) group non- covalently. {ECO 0000269|PubMed 19564607}; # EcoGene EG14165 yfeX # FUNCTION YFEX_ECOLI Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact. {ECO 0000269|PubMed 19564607}. # GO_component GO:0005737 cytoplasm; IDA:EcoCyc. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004601 peroxidase activity; IDA:EcoCyc. # GO_function GO:0020037 heme binding; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # IntAct P76536 4 # InterPro IPR006314 Dyp_peroxidase # InterPro IPR011008 Dimeric_a/b-barrel # Organism YFEX_ECOLI Escherichia coli (strain K12) # PATRIC 32120247 VBIEscCol129921_2526 # PIR F65017 F65017 # PROSITE PS51404 DYP_PEROXIDASE # PeroxiBase 5875 EcoDyPrx02_K12 # Pfam PF04261 Dyp_perox # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFEX_ECOLI Probable deferrochelatase/peroxidase YfeX # RefSeq NP_416926 NC_000913.3 # RefSeq WP_001350538 NZ_LN832404.1 # SIMILARITY Belongs to the DyP-type peroxidase family. {ECO 0000305}. # SUBCELLULAR LOCATION YFEX_ECOLI Cytoplasm {ECO 0000269|PubMed 19564607}. # SUPFAM SSF54909 SSF54909 # TIGRFAMs TIGR01413 Dyp_perox_fam # eggNOG COG2837 LUCA # eggNOG ENOG4105EZR Bacteria BLAST swissprot:YFEX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFEX_ECOLI BioCyc ECOL316407:JW2424-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2424-MONOMER BioCyc EcoCyc:G7266-MONOMER http://biocyc.org/getid?id=EcoCyc:G7266-MONOMER BioCyc MetaCyc:G7266-MONOMER http://biocyc.org/getid?id=MetaCyc:G7266-MONOMER COG COG2837 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2837 DIP DIP-47971N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47971N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0903842106 http://dx.doi.org/10.1073/pnas.0903842106 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.11.1.- http://www.genome.jp/dbget-bin/www_bget?EC:1.11.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.11.1.- http://enzyme.expasy.org/EC/1.11.1.- EchoBASE EB3917 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3917 EcoGene EG14165 http://www.ecogene.org/geneInfo.php?eg_id=EG14165 EnsemblBacteria AAC75484 http://www.ensemblgenomes.org/id/AAC75484 EnsemblBacteria AAC75484 http://www.ensemblgenomes.org/id/AAC75484 EnsemblBacteria BAE76711 http://www.ensemblgenomes.org/id/BAE76711 EnsemblBacteria BAE76711 http://www.ensemblgenomes.org/id/BAE76711 EnsemblBacteria BAE76711 http://www.ensemblgenomes.org/id/BAE76711 EnsemblBacteria b2431 http://www.ensemblgenomes.org/id/b2431 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004601 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004601 GO_function GO:0020037 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0020037 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GeneID 946913 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946913 HOGENOM HOG000151980 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000151980&db=HOGENOM6 InParanoid P76536 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76536 IntAct P76536 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76536* IntEnz 1.11.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.11.1 InterPro IPR006314 http://www.ebi.ac.uk/interpro/entry/IPR006314 InterPro IPR011008 http://www.ebi.ac.uk/interpro/entry/IPR011008 KEGG_Gene ecj:JW2424 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2424 KEGG_Gene eco:b2431 http://www.genome.jp/dbget-bin/www_bget?eco:b2431 KEGG_Orthology KO:K07223 http://www.genome.jp/dbget-bin/www_bget?KO:K07223 OMA CAEPNLH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CAEPNLH PROSITE PS51404 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51404 PSORT swissprot:YFEX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFEX_ECOLI PSORT-B swissprot:YFEX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFEX_ECOLI PSORT2 swissprot:YFEX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFEX_ECOLI PeroxiBase 5875 http://peroxibase.toulouse.inra.fr/listing.php?action=view&id=5875 Pfam PF04261 http://pfam.xfam.org/family/PF04261 Phobius swissprot:YFEX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFEX_ECOLI PhylomeDB P76536 http://phylomedb.org/?seqid=P76536 ProteinModelPortal P76536 http://www.proteinmodelportal.org/query/uniprot/P76536 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19564607 http://www.ncbi.nlm.nih.gov/pubmed/19564607 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416926 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416926 RefSeq WP_001350538 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001350538 SMR P76536 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76536 STRING 511145.b2431 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2431&targetmode=cogs STRING COG2837 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2837&targetmode=cogs SUPFAM SSF54909 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54909 TIGRFAMs TIGR01413 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01413 UniProtKB YFEX_ECOLI http://www.uniprot.org/uniprot/YFEX_ECOLI UniProtKB-AC P76536 http://www.uniprot.org/uniprot/P76536 charge swissprot:YFEX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFEX_ECOLI eggNOG COG2837 http://eggnogapi.embl.de/nog_data/html/tree/COG2837 eggNOG ENOG4105EZR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EZR epestfind swissprot:YFEX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFEX_ECOLI garnier swissprot:YFEX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFEX_ECOLI helixturnhelix swissprot:YFEX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFEX_ECOLI hmoment swissprot:YFEX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFEX_ECOLI iep swissprot:YFEX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFEX_ECOLI inforesidue swissprot:YFEX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFEX_ECOLI octanol swissprot:YFEX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFEX_ECOLI pepcoil swissprot:YFEX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFEX_ECOLI pepdigest swissprot:YFEX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFEX_ECOLI pepinfo swissprot:YFEX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFEX_ECOLI pepnet swissprot:YFEX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFEX_ECOLI pepstats swissprot:YFEX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFEX_ECOLI pepwheel swissprot:YFEX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFEX_ECOLI pepwindow swissprot:YFEX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFEX_ECOLI sigcleave swissprot:YFEX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFEX_ECOLI ## Database ID URL or Descriptions # AltName BHSA_ECOLI Copper-induced outer membrane component # BioGrid 4261348 15 # DISRUPTION PHENOTYPE BHSA_ECOLI Disruption of this gene increases copper sensitivity, induces stress response genes in biofilms, increases aggregation and cell surface hydrophobicity, and decreases indole synthesis. {ECO 0000269|PubMed 17293424, ECO 0000269|PubMed 22089859}. # EcoGene EG13436 bhsA # FUNCTION BHSA_ECOLI Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction. {ECO 0000269|PubMed 17293424, ECO 0000269|PubMed 22089859}. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_process GO:0044010 single-species biofilm formation; IMP:EcoCyc. # GO_process GO:0046688 response to copper ion; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0008150 biological_process # Gene3D 3.30.1660.10 -; 1. # INDUCTION BHSA_ECOLI Repressed by ComR. Induced by copper via release of ComR. Induced in biofilms and by several stress conditions. {ECO 0000269|PubMed 17293424, ECO 0000269|PubMed 22089859}. # InterPro IPR010854 DUF1471 # InterPro IPR025543 Dodecin-like # Organism BHSA_ECOLI Escherichia coli (strain K12) # PATRIC 32117467 VBIEscCol129921_1156 # PIR E64855 E64855 # Pfam PF07338 DUF1471 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BHSA_ECOLI Multiple stress resistance protein BhsA # RefSeq NP_415630 NC_000913.3 # RefSeq WP_000800153 NZ_LN832404.1 # SIMILARITY Belongs to the BhsA/McbA family. {ECO 0000305}. # SUBCELLULAR LOCATION BHSA_ECOLI Cell outer membrane {ECO 0000269|PubMed 22089859}. # SUPFAM SSF159871 SSF159871 # eggNOG ENOG4105RC8 Bacteria # eggNOG ENOG4111Y56 LUCA BLAST swissprot:BHSA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BHSA_ECOLI BioCyc ECOL316407:JW1098-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1098-MONOMER BioCyc EcoCyc:G6570-MONOMER http://biocyc.org/getid?id=EcoCyc:G6570-MONOMER DIP DIP-48158N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48158N DOI 10.1007/s10534-011-9510-x http://dx.doi.org/10.1007/s10534-011-9510-x DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01832-06 http://dx.doi.org/10.1128/JB.01832-06 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3210 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3210 EcoGene EG13436 http://www.ecogene.org/geneInfo.php?eg_id=EG13436 EnsemblBacteria AAC74196 http://www.ensemblgenomes.org/id/AAC74196 EnsemblBacteria AAC74196 http://www.ensemblgenomes.org/id/AAC74196 EnsemblBacteria BAA35927 http://www.ensemblgenomes.org/id/BAA35927 EnsemblBacteria BAA35927 http://www.ensemblgenomes.org/id/BAA35927 EnsemblBacteria BAA35927 http://www.ensemblgenomes.org/id/BAA35927 EnsemblBacteria b1112 http://www.ensemblgenomes.org/id/b1112 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_process GO:0044010 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044010 GO_process GO:0046688 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046688 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.30.1660.10 http://www.cathdb.info/version/latest/superfamily/3.30.1660.10 GeneID 945492 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945492 HOGENOM HOG000117400 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117400&db=HOGENOM6 InterPro IPR010854 http://www.ebi.ac.uk/interpro/entry/IPR010854 InterPro IPR025543 http://www.ebi.ac.uk/interpro/entry/IPR025543 KEGG_Gene ecj:JW1098 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1098 KEGG_Gene eco:b1112 http://www.genome.jp/dbget-bin/www_bget?eco:b1112 KEGG_Orthology KO:K12151 http://www.genome.jp/dbget-bin/www_bget?KO:K12151 OMA PADQHKV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PADQHKV PSORT swissprot:BHSA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BHSA_ECOLI PSORT-B swissprot:BHSA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BHSA_ECOLI PSORT2 swissprot:BHSA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BHSA_ECOLI Pfam PF07338 http://pfam.xfam.org/family/PF07338 Phobius swissprot:BHSA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BHSA_ECOLI PhylomeDB P0AB40 http://phylomedb.org/?seqid=P0AB40 ProteinModelPortal P0AB40 http://www.proteinmodelportal.org/query/uniprot/P0AB40 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17293424 http://www.ncbi.nlm.nih.gov/pubmed/17293424 PubMed 22089859 http://www.ncbi.nlm.nih.gov/pubmed/22089859 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415630 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415630 RefSeq WP_000800153 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000800153 SMR P0AB40 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AB40 STRING 511145.b1112 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1112&targetmode=cogs SUPFAM SSF159871 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF159871 UniProtKB BHSA_ECOLI http://www.uniprot.org/uniprot/BHSA_ECOLI UniProtKB-AC P0AB40 http://www.uniprot.org/uniprot/P0AB40 charge swissprot:BHSA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BHSA_ECOLI eggNOG ENOG4105RC8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105RC8 eggNOG ENOG4111Y56 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111Y56 epestfind swissprot:BHSA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BHSA_ECOLI garnier swissprot:BHSA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BHSA_ECOLI helixturnhelix swissprot:BHSA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BHSA_ECOLI hmoment swissprot:BHSA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BHSA_ECOLI iep swissprot:BHSA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BHSA_ECOLI inforesidue swissprot:BHSA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BHSA_ECOLI octanol swissprot:BHSA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BHSA_ECOLI pepcoil swissprot:BHSA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BHSA_ECOLI pepdigest swissprot:BHSA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BHSA_ECOLI pepinfo swissprot:BHSA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BHSA_ECOLI pepnet swissprot:BHSA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BHSA_ECOLI pepstats swissprot:BHSA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BHSA_ECOLI pepwheel swissprot:BHSA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BHSA_ECOLI pepwindow swissprot:BHSA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BHSA_ECOLI sigcleave swissprot:BHSA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BHSA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261982 17 # EcoGene EG13245 ybaQ # GO_function GO:0043565 sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.260.40 -; 1. # IntAct P0A9T6 4 # InterPro IPR001387 Cro/C1-type_HTH # InterPro IPR010982 Lambda_DNA-bd_dom # InterPro IPR013430 Toxin_antidote_HigA # Organism YBAQ_ECOLI Escherichia coli (strain K12) # PATRIC 32116123 VBIEscCol129921_0503 # PDB 2EBY X-ray; 2.25 A; A/B=1-113 # PIR B64779 B64779 # PROSITE PS50943 HTH_CROC1 # Pfam PF01381 HTH_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBAQ_ECOLI Uncharacterized HTH-type transcriptional regulator YbaQ # RefSeq NP_415016 NC_000913.3 # RefSeq WP_000806442 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40237.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the VapA/VapI family. {ECO 0000305}. # SIMILARITY Contains 1 HTH cro/C1-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00257}. # SMART SM00530 HTH_XRE # SUPFAM SSF47413 SSF47413 # TIGRFAMs TIGR02607 antidote_HigA # eggNOG COG3093 LUCA # eggNOG ENOG41081XE Bacteria BLAST swissprot:YBAQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBAQ_ECOLI BioCyc ECOL316407:JW0472-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0472-MONOMER BioCyc EcoCyc:G6259-MONOMER http://biocyc.org/getid?id=EcoCyc:G6259-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U58330 http://www.ebi.ac.uk/ena/data/view/U58330 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EchoBASE EB3034 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3034 EcoGene EG13245 http://www.ecogene.org/geneInfo.php?eg_id=EG13245 EnsemblBacteria AAC73585 http://www.ensemblgenomes.org/id/AAC73585 EnsemblBacteria AAC73585 http://www.ensemblgenomes.org/id/AAC73585 EnsemblBacteria BAE76262 http://www.ensemblgenomes.org/id/BAE76262 EnsemblBacteria BAE76262 http://www.ensemblgenomes.org/id/BAE76262 EnsemblBacteria BAE76262 http://www.ensemblgenomes.org/id/BAE76262 EnsemblBacteria b0483 http://www.ensemblgenomes.org/id/b0483 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.260.40 http://www.cathdb.info/version/latest/superfamily/1.10.260.40 GeneID 948800 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948800 HOGENOM HOG000265973 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000265973&db=HOGENOM6 InParanoid P0A9T6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9T6 IntAct P0A9T6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9T6* InterPro IPR001387 http://www.ebi.ac.uk/interpro/entry/IPR001387 InterPro IPR010982 http://www.ebi.ac.uk/interpro/entry/IPR010982 InterPro IPR013430 http://www.ebi.ac.uk/interpro/entry/IPR013430 KEGG_Gene ecj:JW0472 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0472 KEGG_Gene eco:b0483 http://www.genome.jp/dbget-bin/www_bget?eco:b0483 OMA VNELCND http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VNELCND PDB 2EBY http://www.ebi.ac.uk/pdbe-srv/view/entry/2EBY PDBsum 2EBY http://www.ebi.ac.uk/pdbsum/2EBY PROSITE PS50943 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50943 PSORT swissprot:YBAQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBAQ_ECOLI PSORT-B swissprot:YBAQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBAQ_ECOLI PSORT2 swissprot:YBAQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBAQ_ECOLI Pfam PF01381 http://pfam.xfam.org/family/PF01381 Phobius swissprot:YBAQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBAQ_ECOLI PhylomeDB P0A9T6 http://phylomedb.org/?seqid=P0A9T6 ProteinModelPortal P0A9T6 http://www.proteinmodelportal.org/query/uniprot/P0A9T6 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415016 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415016 RefSeq WP_000806442 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000806442 SMART SM00530 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00530 SMR P0A9T6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9T6 STRING 511145.b0483 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0483&targetmode=cogs SUPFAM SSF47413 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47413 TIGRFAMs TIGR02607 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02607 UniProtKB YBAQ_ECOLI http://www.uniprot.org/uniprot/YBAQ_ECOLI UniProtKB-AC P0A9T6 http://www.uniprot.org/uniprot/P0A9T6 charge swissprot:YBAQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBAQ_ECOLI eggNOG COG3093 http://eggnogapi.embl.de/nog_data/html/tree/COG3093 eggNOG ENOG41081XE http://eggnogapi.embl.de/nog_data/html/tree/ENOG41081XE epestfind swissprot:YBAQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBAQ_ECOLI garnier swissprot:YBAQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBAQ_ECOLI helixturnhelix swissprot:YBAQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBAQ_ECOLI hmoment swissprot:YBAQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBAQ_ECOLI iep swissprot:YBAQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBAQ_ECOLI inforesidue swissprot:YBAQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBAQ_ECOLI octanol swissprot:YBAQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBAQ_ECOLI pepcoil swissprot:YBAQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBAQ_ECOLI pepdigest swissprot:YBAQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBAQ_ECOLI pepinfo swissprot:YBAQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBAQ_ECOLI pepnet swissprot:YBAQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBAQ_ECOLI pepstats swissprot:YBAQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBAQ_ECOLI pepwheel swissprot:YBAQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBAQ_ECOLI pepwindow swissprot:YBAQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBAQ_ECOLI sigcleave swissprot:YBAQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBAQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4260783 12 # EcoGene EG10083 aroM # FUNCTION AROM_ECOLI This protein of unknown function is encoded by a gene that cotranscribes with the aroL gene, which codes for shikimate kinase II. # GO_process GO:0008652 cellular amino acid biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0009073 aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW. # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # IntAct P0AE28 3 # InterPro IPR010843 Uncharacterised_AroM # Organism AROM_ECOLI Escherichia coli (strain K12) # PATRIC 32115921 VBIEscCol129921_0402 # PIR F64767 BVECAM # Pfam PF07302 AroM # ProDom PD037589 AroM # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AROM_ECOLI Protein AroM # RefSeq NP_414924 NC_000913.3 # RefSeq WP_001276420 NZ_LN832404.1 # eggNOG ENOG4105HBA Bacteria # eggNOG ENOG410XSID LUCA BLAST swissprot:AROM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AROM_ECOLI BioCyc ECOL316407:JW0381-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0381-MONOMER BioCyc EcoCyc:EG10083-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10083-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M13045 http://www.ebi.ac.uk/ena/data/view/M13045 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EMBL X76979 http://www.ebi.ac.uk/ena/data/view/X76979 EchoBASE EB0081 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0081 EcoGene EG10083 http://www.ecogene.org/geneInfo.php?eg_id=EG10083 EnsemblBacteria AAC73493 http://www.ensemblgenomes.org/id/AAC73493 EnsemblBacteria AAC73493 http://www.ensemblgenomes.org/id/AAC73493 EnsemblBacteria BAE76171 http://www.ensemblgenomes.org/id/BAE76171 EnsemblBacteria BAE76171 http://www.ensemblgenomes.org/id/BAE76171 EnsemblBacteria BAE76171 http://www.ensemblgenomes.org/id/BAE76171 EnsemblBacteria b0390 http://www.ensemblgenomes.org/id/b0390 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0008652 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008652 GO_process GO:0009073 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009073 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 945045 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945045 HOGENOM HOG000117533 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117533&db=HOGENOM6 InParanoid P0AE28 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AE28 IntAct P0AE28 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AE28* InterPro IPR010843 http://www.ebi.ac.uk/interpro/entry/IPR010843 KEGG_Gene ecj:JW0381 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0381 KEGG_Gene eco:b0390 http://www.genome.jp/dbget-bin/www_bget?eco:b0390 KEGG_Orthology KO:K14591 http://www.genome.jp/dbget-bin/www_bget?KO:K14591 OMA DRIIPPL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DRIIPPL PSORT swissprot:AROM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AROM_ECOLI PSORT-B swissprot:AROM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AROM_ECOLI PSORT2 swissprot:AROM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AROM_ECOLI Pfam PF07302 http://pfam.xfam.org/family/PF07302 Phobius swissprot:AROM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AROM_ECOLI ProteinModelPortal P0AE28 http://www.proteinmodelportal.org/query/uniprot/P0AE28 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3001025 http://www.ncbi.nlm.nih.gov/pubmed/3001025 PubMed 8807285 http://www.ncbi.nlm.nih.gov/pubmed/8807285 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414924 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414924 RefSeq WP_001276420 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001276420 STRING 511145.b0390 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0390&targetmode=cogs UniProtKB AROM_ECOLI http://www.uniprot.org/uniprot/AROM_ECOLI UniProtKB-AC P0AE28 http://www.uniprot.org/uniprot/P0AE28 charge swissprot:AROM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AROM_ECOLI eggNOG ENOG4105HBA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105HBA eggNOG ENOG410XSID http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XSID epestfind swissprot:AROM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AROM_ECOLI garnier swissprot:AROM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AROM_ECOLI helixturnhelix swissprot:AROM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AROM_ECOLI hmoment swissprot:AROM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AROM_ECOLI iep swissprot:AROM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AROM_ECOLI inforesidue swissprot:AROM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AROM_ECOLI octanol swissprot:AROM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AROM_ECOLI pepcoil swissprot:AROM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AROM_ECOLI pepdigest swissprot:AROM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AROM_ECOLI pepinfo swissprot:AROM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AROM_ECOLI pepnet swissprot:AROM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AROM_ECOLI pepstats swissprot:AROM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AROM_ECOLI pepwheel swissprot:AROM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AROM_ECOLI pepwindow swissprot:AROM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AROM_ECOLI sigcleave swissprot:AROM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AROM_ECOLI ## Database ID URL or Descriptions # AltName DMLA_ECOLI D-malate degradation protein A # AltName DMLA_ECOLI D-malate oxidase # BRENDA 1.1.1.83 2026 # BioGrid 4260335 13 # CATALYTIC ACTIVITY DMLA_ECOLI (R)-malate + NAD(+) = pyruvate + CO(2) + NADH. {ECO 0000269|PubMed 17088549, ECO 0000269|PubMed 20233924}. # COFACTOR DMLA_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000250}; Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit. {ECO 0000250}; # DISRUPTION PHENOTYPE DMLA_ECOLI Deletion of dmlA inhibits aerobic growth on D-malate but does not impair slow anaerobic growth on D-malate. {ECO 0000269|PubMed 17088549, ECO 0000269|PubMed 20233924}. # EcoGene EG13507 dmlA # FUNCTION DMLA_ECOLI Catalyzes the NAD(+)-dependent oxidative decarboxylation of D-malate into pyruvate. Is essential for aerobic growth on D- malate as the sole carbon source. But is not required for anaerobic D-malate utilization, although DmlA is expressed and active in those conditions. Appears to be not able to use L- tartrate as a substrate for dehydrogenation instead of D-malate. {ECO 0000269|PubMed 20233924}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0003862 3-isopropylmalate dehydrogenase activity; IDA:EcoCyc. # GO_function GO:0009027 tartrate dehydrogenase activity; IDA:EcoCyc. # GO_function GO:0046553 D-malate dehydrogenase (decarboxylating) activity; IDA:UniProtKB. # GO_function GO:0051287 NAD binding; IDA:EcoCyc. # GO_process GO:0006108 malate metabolic process; IDA:UniProtKB. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.718.10 -; 1. # INDUCTION By the transcriptional regulator DmlR in the presence of D-malate or L- or meso-tartrate, under aerobic conditions. Is not induced by L-malate, D-tartrate or succinate. Is also induced at high levels under anaerobic conditions in the presence of D- malate and its expression is more than 5-fold greater than the one under aerobic conditions. Repressed by glucose or nitrate under anaerobic conditions. During aerobic growth, appears to be repressed by the DcuS-DcuR two-component system, and is not repressed by glucose. {ECO:0000269|PubMed 20233924}. # IntAct P76251 3 # InterPro IPR001804 Isocitrate/isopropylmalate_DH # InterPro IPR011829 TTC_DH # InterPro IPR019818 IsoCit/isopropylmalate_DH_CS # InterPro IPR024084 IsoPropMal-DH-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00630 Glyoxylate and dicarboxylate metabolism # KEGG_Pathway ko00650 Butanoate metabolism # MISCELLANEOUS DMLA_ECOLI Aerobic growth on D-malate requires, in addition to DmlA, the presence of the aerobic C4-dicarboxylate transporter DctA, for D-malate uptake. Meso-tartrate or L-tartrate are not able to support aerobic growth. Slow anaerobic growth on D-malate is observed only when glycerol is also provided as an electron donor, and D-malate is used in fumarate respiration, so is not dependent on DmlA. # Organism DMLA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11835 PTHR11835 # PATRIC 32118917 VBIEscCol129921_1876 # PIR H64940 H64940 # PROSITE PS00470 IDH_IMDH # Pfam PF00180 Iso_dh # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DMLA_ECOLI D-malate dehydrogenase [decarboxylating] # RefSeq NP_416314 NC_000913.3 # RefSeq WP_000978494 NZ_LN832404.1 # SIMILARITY Belongs to the isocitrate and isopropylmalate dehydrogenases family. {ECO 0000305}. # SMART SM01329 Iso_dh # SUBCELLULAR LOCATION DMLA_ECOLI Cytoplasm {ECO 0000250}. # TIGRFAMs TIGR02089 TTC # eggNOG COG0473 LUCA # eggNOG ENOG4105C0C Bacteria BLAST swissprot:DMLA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DMLA_ECOLI BioCyc ECOL316407:JW1789-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1789-MONOMER BioCyc EcoCyc:G6986-MONOMER http://biocyc.org/getid?id=EcoCyc:G6986-MONOMER BioCyc MetaCyc:G6986-MONOMER http://biocyc.org/getid?id=MetaCyc:G6986-MONOMER COG COG0473 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0473 DIP DIP-11800N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11800N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0603364103 http://dx.doi.org/10.1073/pnas.0603364103 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01665-09 http://dx.doi.org/10.1128/JB.01665-09 EC_number EC:1.1.1.83 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.83 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.1.1.83 http://enzyme.expasy.org/EC/1.1.1.83 EchoBASE EB3280 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3280 EcoGene EG13507 http://www.ecogene.org/geneInfo.php?eg_id=EG13507 EnsemblBacteria AAC74870 http://www.ensemblgenomes.org/id/AAC74870 EnsemblBacteria AAC74870 http://www.ensemblgenomes.org/id/AAC74870 EnsemblBacteria BAA15595 http://www.ensemblgenomes.org/id/BAA15595 EnsemblBacteria BAA15595 http://www.ensemblgenomes.org/id/BAA15595 EnsemblBacteria BAA15595 http://www.ensemblgenomes.org/id/BAA15595 EnsemblBacteria b1800 http://www.ensemblgenomes.org/id/b1800 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0003862 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003862 GO_function GO:0009027 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009027 GO_function GO:0046553 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046553 GO_function GO:0051287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051287 GO_process GO:0006108 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006108 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.718.10 http://www.cathdb.info/version/latest/superfamily/3.40.718.10 GeneID 946319 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946319 HOGENOM HOG000021111 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000021111&db=HOGENOM6 InParanoid P76251 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76251 IntAct P76251 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76251* IntEnz 1.1.1.83 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.83 InterPro IPR001804 http://www.ebi.ac.uk/interpro/entry/IPR001804 InterPro IPR011829 http://www.ebi.ac.uk/interpro/entry/IPR011829 InterPro IPR019818 http://www.ebi.ac.uk/interpro/entry/IPR019818 InterPro IPR024084 http://www.ebi.ac.uk/interpro/entry/IPR024084 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1789 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1789 KEGG_Gene eco:b1800 http://www.genome.jp/dbget-bin/www_bget?eco:b1800 KEGG_Orthology KO:K07246 http://www.genome.jp/dbget-bin/www_bget?KO:K07246 KEGG_Pathway ko00630 http://www.genome.jp/kegg-bin/show_pathway?ko00630 KEGG_Pathway ko00650 http://www.genome.jp/kegg-bin/show_pathway?ko00650 KEGG_Reaction rn:R00215 http://www.genome.jp/dbget-bin/www_bget?rn:R00215 KEGG_Reaction rn:R01751 http://www.genome.jp/dbget-bin/www_bget?rn:R01751 KEGG_Reaction rn:R02545 http://www.genome.jp/dbget-bin/www_bget?rn:R02545 KEGG_Reaction rn:R06180 http://www.genome.jp/dbget-bin/www_bget?rn:R06180 MINT MINT-1273575 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1273575 OMA WGFDLSF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WGFDLSF PANTHER PTHR11835 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11835 PROSITE PS00470 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00470 PSORT swissprot:DMLA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DMLA_ECOLI PSORT-B swissprot:DMLA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DMLA_ECOLI PSORT2 swissprot:DMLA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DMLA_ECOLI Pfam PF00180 http://pfam.xfam.org/family/PF00180 Phobius swissprot:DMLA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DMLA_ECOLI PhylomeDB P76251 http://phylomedb.org/?seqid=P76251 ProteinModelPortal P76251 http://www.proteinmodelportal.org/query/uniprot/P76251 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17088549 http://www.ncbi.nlm.nih.gov/pubmed/17088549 PubMed 20233924 http://www.ncbi.nlm.nih.gov/pubmed/20233924 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416314 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416314 RefSeq WP_000978494 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000978494 SMART SM01329 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01329 SMR P76251 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76251 STRING 511145.b1800 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1800&targetmode=cogs STRING COG0473 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0473&targetmode=cogs TIGRFAMs TIGR02089 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02089 UniProtKB DMLA_ECOLI http://www.uniprot.org/uniprot/DMLA_ECOLI UniProtKB-AC P76251 http://www.uniprot.org/uniprot/P76251 charge swissprot:DMLA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DMLA_ECOLI eggNOG COG0473 http://eggnogapi.embl.de/nog_data/html/tree/COG0473 eggNOG ENOG4105C0C http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C0C epestfind swissprot:DMLA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DMLA_ECOLI garnier swissprot:DMLA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DMLA_ECOLI helixturnhelix swissprot:DMLA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DMLA_ECOLI hmoment swissprot:DMLA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DMLA_ECOLI iep swissprot:DMLA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DMLA_ECOLI inforesidue swissprot:DMLA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DMLA_ECOLI octanol swissprot:DMLA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DMLA_ECOLI pepcoil swissprot:DMLA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DMLA_ECOLI pepdigest swissprot:DMLA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DMLA_ECOLI pepinfo swissprot:DMLA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DMLA_ECOLI pepnet swissprot:DMLA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DMLA_ECOLI pepstats swissprot:DMLA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DMLA_ECOLI pepwheel swissprot:DMLA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DMLA_ECOLI pepwindow swissprot:DMLA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DMLA_ECOLI sigcleave swissprot:DMLA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DMLA_ECOLI ## Database ID URL or Descriptions # AltName TFAE_ECOLI Tail fiber assembly protein homolog from lambdoid prophage e14 # BioGrid 4262857 21 # EcoGene EG11120 tfaE # INTERACTION TFAE_ECOLI P0AFB5 glnL; NbExp=4; IntAct=EBI-9133821, EBI-701156; # IntAct P09153 16 # InterPro IPR003458 Phage_T4_Gp38_tail_assem # Organism TFAE_ECOLI Escherichia coli (strain K12) # PATRIC 32117549 VBIEscCol129921_1197 # PIR A64861 A64861 # Pfam PF02413 Caudo_TAP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Prophage tail fiber assembly protein homolog TfaE {ECO 0000305} # RefSeq NP_415674 NC_000913.3 # RefSeq WP_000548498 NZ_CP010440.1 # SIMILARITY Belongs to the tfa family. {ECO 0000305}. # eggNOG ENOG4108US3 Bacteria # eggNOG ENOG4111IKE LUCA BLAST swissprot:TFAE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TFAE_ECOLI BioCyc ECOL316407:JW1142-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1142-MONOMER BioCyc EcoCyc:EG11120-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11120-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X01805 http://www.ebi.ac.uk/ena/data/view/X01805 EchoBASE EB1110 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1110 EcoGene EG11120 http://www.ecogene.org/geneInfo.php?eg_id=EG11120 EnsemblBacteria AAC74240 http://www.ensemblgenomes.org/id/AAC74240 EnsemblBacteria AAC74240 http://www.ensemblgenomes.org/id/AAC74240 EnsemblBacteria BAE76382 http://www.ensemblgenomes.org/id/BAE76382 EnsemblBacteria BAE76382 http://www.ensemblgenomes.org/id/BAE76382 EnsemblBacteria BAE76382 http://www.ensemblgenomes.org/id/BAE76382 EnsemblBacteria b1156 http://www.ensemblgenomes.org/id/b1156 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945723 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945723 HOGENOM HOG000118670 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118670&db=HOGENOM6 IntAct P09153 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P09153* InterPro IPR003458 http://www.ebi.ac.uk/interpro/entry/IPR003458 KEGG_Gene ecj:JW1142 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1142 KEGG_Gene eco:b1156 http://www.genome.jp/dbget-bin/www_bget?eco:b1156 OMA PYDEWDG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PYDEWDG PSORT swissprot:TFAE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TFAE_ECOLI PSORT-B swissprot:TFAE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TFAE_ECOLI PSORT2 swissprot:TFAE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TFAE_ECOLI Pfam PF02413 http://pfam.xfam.org/family/PF02413 Phobius swissprot:TFAE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TFAE_ECOLI PhylomeDB P09153 http://phylomedb.org/?seqid=P09153 ProteinModelPortal P09153 http://www.proteinmodelportal.org/query/uniprot/P09153 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3894006 http://www.ncbi.nlm.nih.gov/pubmed/3894006 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415674 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415674 RefSeq WP_000548498 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000548498 STRING 511145.b1156 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1156&targetmode=cogs UniProtKB TFAE_ECOLI http://www.uniprot.org/uniprot/TFAE_ECOLI UniProtKB-AC P09153 http://www.uniprot.org/uniprot/P09153 charge swissprot:TFAE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TFAE_ECOLI eggNOG ENOG4108US3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108US3 eggNOG ENOG4111IKE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111IKE epestfind swissprot:TFAE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TFAE_ECOLI garnier swissprot:TFAE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TFAE_ECOLI helixturnhelix swissprot:TFAE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TFAE_ECOLI hmoment swissprot:TFAE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TFAE_ECOLI iep swissprot:TFAE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TFAE_ECOLI inforesidue swissprot:TFAE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TFAE_ECOLI octanol swissprot:TFAE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TFAE_ECOLI pepcoil swissprot:TFAE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TFAE_ECOLI pepdigest swissprot:TFAE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TFAE_ECOLI pepinfo swissprot:TFAE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TFAE_ECOLI pepnet swissprot:TFAE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TFAE_ECOLI pepstats swissprot:TFAE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TFAE_ECOLI pepwheel swissprot:TFAE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TFAE_ECOLI pepwindow swissprot:TFAE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TFAE_ECOLI sigcleave swissprot:TFAE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TFAE_ECOLI ## Database ID URL or Descriptions # BioGrid 4260466 20 # CDD cd04470 S1_EF-P_repeat_1 # CDD cd05794 S1_EF-P_repeat_2 # EcoGene EG12035 yeiP # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003746 translation elongation factor activity; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0008135 translation factor activity, RNA binding # Gene3D 2.30.30.30 -; 1. # HAMAP MF_00646 EFP # InterPro IPR001059 Transl_elong_P/YeiP_cen # InterPro IPR008991 Translation_prot_SH3-like # InterPro IPR011897 Transl_elong_p-like_YeiP # InterPro IPR012340 NA-bd_OB-fold # InterPro IPR013185 Transl_elong_KOW-like # InterPro IPR013852 Transl_elong_P/YeiP_CS # InterPro IPR014722 Rib_L2_dom2 # InterPro IPR015365 Elong-fact-P_C # InterPro IPR020599 Transl_elong_fac_P/YeiP # KEGG_Brite ko03012 Translation factors # Organism EFPL_ECOLI Escherichia coli (strain K12) # PATRIC 32119697 VBIEscCol129921_2259 # PIR B64986 B64986 # PIRSF PIRSF005901 EF-P # PROSITE PS01275 EFP # Pfam PF01132 EFP # Pfam PF08207 EFP_N # Pfam PF09285 Elong-fact-P_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EFPL_ECOLI Elongation factor P-like protein # RefSeq NP_416676 NC_000913.3 # RefSeq WP_001136827 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA60519.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the elongation factor P family. {ECO 0000305}. # SMART SM00841 Elong-fact-P_C # SMART SM01185 EFP # SUPFAM SSF50104 SSF50104 # SUPFAM SSF50249 SSF50249; 2 # TIGRFAMs TIGR02178 yeiP # eggNOG COG0231 LUCA # eggNOG ENOG4105FUQ Bacteria BLAST swissprot:EFPL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EFPL_ECOLI BioCyc ECOL316407:JW5362-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5362-MONOMER BioCyc EcoCyc:EG12035-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12035-MONOMER COG COG0231 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0231 DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1271/bbb.58.117 http://dx.doi.org/10.1271/bbb.58.117 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D21148 http://www.ebi.ac.uk/ena/data/view/D21148 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1970 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1970 EcoGene EG12035 http://www.ecogene.org/geneInfo.php?eg_id=EG12035 EnsemblBacteria AAC75232 http://www.ensemblgenomes.org/id/AAC75232 EnsemblBacteria AAC75232 http://www.ensemblgenomes.org/id/AAC75232 EnsemblBacteria BAA15980 http://www.ensemblgenomes.org/id/BAA15980 EnsemblBacteria BAA15980 http://www.ensemblgenomes.org/id/BAA15980 EnsemblBacteria BAA15980 http://www.ensemblgenomes.org/id/BAA15980 EnsemblBacteria b2171 http://www.ensemblgenomes.org/id/b2171 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003746 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0008135 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008135 Gene3D 2.30.30.30 http://www.cathdb.info/version/latest/superfamily/2.30.30.30 GeneID 946674 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946674 HAMAP MF_00646 http://hamap.expasy.org/unirule/MF_00646 HOGENOM HOG000010049 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000010049&db=HOGENOM6 InParanoid P0A6N8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6N8 InterPro IPR001059 http://www.ebi.ac.uk/interpro/entry/IPR001059 InterPro IPR008991 http://www.ebi.ac.uk/interpro/entry/IPR008991 InterPro IPR011897 http://www.ebi.ac.uk/interpro/entry/IPR011897 InterPro IPR012340 http://www.ebi.ac.uk/interpro/entry/IPR012340 InterPro IPR013185 http://www.ebi.ac.uk/interpro/entry/IPR013185 InterPro IPR013852 http://www.ebi.ac.uk/interpro/entry/IPR013852 InterPro IPR014722 http://www.ebi.ac.uk/interpro/entry/IPR014722 InterPro IPR015365 http://www.ebi.ac.uk/interpro/entry/IPR015365 InterPro IPR020599 http://www.ebi.ac.uk/interpro/entry/IPR020599 KEGG_Brite ko03012 http://www.genome.jp/dbget-bin/www_bget?ko03012 KEGG_Gene ecj:JW5362 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5362 KEGG_Gene eco:b2171 http://www.genome.jp/dbget-bin/www_bget?eco:b2171 KEGG_Orthology KO:K02356 http://www.genome.jp/dbget-bin/www_bget?KO:K02356 MINT MINT-1302160 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1302160 OMA TMEYSER http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TMEYSER PROSITE PS01275 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01275 PSORT swissprot:EFPL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EFPL_ECOLI PSORT-B swissprot:EFPL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EFPL_ECOLI PSORT2 swissprot:EFPL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EFPL_ECOLI Pfam PF01132 http://pfam.xfam.org/family/PF01132 Pfam PF08207 http://pfam.xfam.org/family/PF08207 Pfam PF09285 http://pfam.xfam.org/family/PF09285 Phobius swissprot:EFPL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EFPL_ECOLI PhylomeDB P0A6N8 http://phylomedb.org/?seqid=P0A6N8 ProteinModelPortal P0A6N8 http://www.proteinmodelportal.org/query/uniprot/P0A6N8 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7764507 http://www.ncbi.nlm.nih.gov/pubmed/7764507 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416676 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416676 RefSeq WP_001136827 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001136827 SMART SM00841 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00841 SMART SM01185 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01185 SMR P0A6N8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6N8 STRING 511145.b2171 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2171&targetmode=cogs STRING COG0231 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0231&targetmode=cogs SUPFAM SSF50104 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50104 SUPFAM SSF50249 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50249 TIGRFAMs TIGR02178 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02178 UniProtKB EFPL_ECOLI http://www.uniprot.org/uniprot/EFPL_ECOLI UniProtKB-AC P0A6N8 http://www.uniprot.org/uniprot/P0A6N8 charge swissprot:EFPL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EFPL_ECOLI eggNOG COG0231 http://eggnogapi.embl.de/nog_data/html/tree/COG0231 eggNOG ENOG4105FUQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FUQ epestfind swissprot:EFPL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EFPL_ECOLI garnier swissprot:EFPL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EFPL_ECOLI helixturnhelix swissprot:EFPL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EFPL_ECOLI hmoment swissprot:EFPL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EFPL_ECOLI iep swissprot:EFPL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EFPL_ECOLI inforesidue swissprot:EFPL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EFPL_ECOLI octanol swissprot:EFPL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EFPL_ECOLI pepcoil swissprot:EFPL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EFPL_ECOLI pepdigest swissprot:EFPL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EFPL_ECOLI pepinfo swissprot:EFPL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EFPL_ECOLI pepnet swissprot:EFPL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EFPL_ECOLI pepstats swissprot:EFPL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EFPL_ECOLI pepwheel swissprot:EFPL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EFPL_ECOLI pepwindow swissprot:EFPL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EFPL_ECOLI sigcleave swissprot:EFPL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EFPL_ECOLI ## Database ID URL or Descriptions # BioGrid 4261588 11 # EcoGene EG13391 yeeX # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # HAMAP MF_00683 UPF0265 # IntAct P0A8M6 4 # InterPro IPR007458 DUF496 # Organism YEEX_ECOLI Escherichia coli (strain K12) # PATRIC 32119347 VBIEscCol129921_2083 # PIR F64965 F64965 # PIRSF PIRSF028773 UCP028773 # Pfam PF04363 DUF496 # ProDom PD030876 DUF496 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEEX_ECOLI UPF0265 protein YeeX # RefSeq NP_416511 NC_000913.3 # RefSeq WP_000450409 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA15828.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the UPF0265 family. {ECO 0000305}. # eggNOG COG2926 LUCA # eggNOG ENOG41090HJ Bacteria BLAST swissprot:YEEX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEEX_ECOLI BioCyc ECOL316407:JW1989-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1989-MONOMER BioCyc EcoCyc:G7087-MONOMER http://biocyc.org/getid?id=EcoCyc:G7087-MONOMER COG COG2926 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2926 DIP DIP-47887N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47887N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1111/j.1574-6968.1998.tb13343.x http://dx.doi.org/10.1111/j.1574-6968.1998.tb13343.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3172 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3172 EcoGene EG13391 http://www.ecogene.org/geneInfo.php?eg_id=EG13391 EnsemblBacteria AAC75068 http://www.ensemblgenomes.org/id/AAC75068 EnsemblBacteria AAC75068 http://www.ensemblgenomes.org/id/AAC75068 EnsemblBacteria BAA15828 http://www.ensemblgenomes.org/id/BAA15828 EnsemblBacteria BAA15828 http://www.ensemblgenomes.org/id/BAA15828 EnsemblBacteria BAA15828 http://www.ensemblgenomes.org/id/BAA15828 EnsemblBacteria b2007 http://www.ensemblgenomes.org/id/b2007 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GeneID 946541 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946541 HAMAP MF_00683 http://hamap.expasy.org/unirule/MF_00683 HOGENOM HOG000284053 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000284053&db=HOGENOM6 InParanoid P0A8M6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8M6 IntAct P0A8M6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8M6* InterPro IPR007458 http://www.ebi.ac.uk/interpro/entry/IPR007458 KEGG_Gene ecj:JW1989 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1989 KEGG_Gene eco:b2007 http://www.genome.jp/dbget-bin/www_bget?eco:b2007 KEGG_Orthology KO:K09802 http://www.genome.jp/dbget-bin/www_bget?KO:K09802 MINT MINT-1275307 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1275307 OMA IANMRSD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IANMRSD PSORT swissprot:YEEX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEEX_ECOLI PSORT-B swissprot:YEEX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEEX_ECOLI PSORT2 swissprot:YEEX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEEX_ECOLI Pfam PF04363 http://pfam.xfam.org/family/PF04363 Phobius swissprot:YEEX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEEX_ECOLI ProteinModelPortal P0A8M6 http://www.proteinmodelportal.org/query/uniprot/P0A8M6 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9868784 http://www.ncbi.nlm.nih.gov/pubmed/9868784 RefSeq NP_416511 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416511 RefSeq WP_000450409 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000450409 STRING 511145.b2007 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2007&targetmode=cogs STRING COG2926 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2926&targetmode=cogs UniProtKB YEEX_ECOLI http://www.uniprot.org/uniprot/YEEX_ECOLI UniProtKB-AC P0A8M6 http://www.uniprot.org/uniprot/P0A8M6 charge swissprot:YEEX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEEX_ECOLI eggNOG COG2926 http://eggnogapi.embl.de/nog_data/html/tree/COG2926 eggNOG ENOG41090HJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG41090HJ epestfind swissprot:YEEX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEEX_ECOLI garnier swissprot:YEEX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEEX_ECOLI helixturnhelix swissprot:YEEX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEEX_ECOLI hmoment swissprot:YEEX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEEX_ECOLI iep swissprot:YEEX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEEX_ECOLI inforesidue swissprot:YEEX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEEX_ECOLI octanol swissprot:YEEX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEEX_ECOLI pepcoil swissprot:YEEX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEEX_ECOLI pepdigest swissprot:YEEX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEEX_ECOLI pepinfo swissprot:YEEX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEEX_ECOLI pepnet swissprot:YEEX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEEX_ECOLI pepstats swissprot:YEEX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEEX_ECOLI pepwheel swissprot:YEEX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEEX_ECOLI pepwindow swissprot:YEEX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEEX_ECOLI sigcleave swissprot:YEEX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEEX_ECOLI ## Database ID URL or Descriptions # AltName RCLR_ECOLI Reactive chlorine resistance protein R # BioGrid 4262810 9 # DISRUPTION PHENOTYPE Mutants are more sensitive to HOCl treatment than wild-type cells. {ECO:0000269|PubMed 24078635}. # ENZYME REGULATION Oxydation of Cys-21 leads to partial activation of RclR, followed by the formation of an intramolecular disulfide bond between Cys-21 and Cys-89, which stabilizes the active form of RclR. {ECO:0000305|PubMed 24078635}. # EcoGene EG13581 rclR # FUNCTION RCLR_ECOLI Involved in reactive chlorine species (RCS) stress resistance. Upregulates, in response to hypochlorous acid (HOCl), the expression of three genes essential for survival of RCS stress (rclA, rclB and rclC) and its own expression. {ECO 0000269|PubMed 24078635}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0000987 core promoter proximal region sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0001216 bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; ISS:EcoCyc. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IEP:EcoCyc. # GO_process GO:0090347 regulation of cellular organohalogen metabolic process; IEP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.60 -; 2. # Gene3D 2.60.120.10 -; 1. # INDUCTION Autoregulated. Induced in response to HOCl. {ECO:0000269|PubMed 24078635}. # IntAct P77379 5 # InterPro IPR009057 Homeodomain-like # InterPro IPR011051 RmlC_Cupin # InterPro IPR014710 RmlC-like_jellyroll # InterPro IPR018060 HTH_AraC # InterPro IPR020449 Tscrpt_reg_HTH_AraC-type # InterPro IPR032783 AraC_lig # Organism RCLR_ECOLI Escherichia coli (strain K12) # PATRIC 32115739 VBIEscCol129921_0312 # PIR A64757 A64757 # PRINTS PR00032 HTHARAC # PROSITE PS01124 HTH_ARAC_FAMILY_2 # Pfam PF12833 HTH_18 # Pfam PF12852 Cupin_6 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RCLR_ECOLI RCS-specific HTH-type transcriptional activator RclR # RefSeq NP_414839 NC_000913.3 # RefSeq WP_000339594 NZ_LN832404.1 # SIMILARITY Contains 1 HTH araC/xylS-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00593}. # SMART SM00342 HTH_ARAC # SUPFAM SSF46689 SSF46689; 2 # SUPFAM SSF51182 SSF51182 # eggNOG COG2207 LUCA # eggNOG ENOG4108K01 Bacteria BLAST swissprot:RCLR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RCLR_ECOLI BioCyc ECOL316407:JW0298-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0298-MONOMER BioCyc EcoCyc:G6175-MONOMER http://biocyc.org/getid?id=EcoCyc:G6175-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M113.503516 http://dx.doi.org/10.1074/jbc.M113.503516 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB3351 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3351 EcoGene EG13581 http://www.ecogene.org/geneInfo.php?eg_id=EG13581 EnsemblBacteria AAC73408 http://www.ensemblgenomes.org/id/AAC73408 EnsemblBacteria AAC73408 http://www.ensemblgenomes.org/id/AAC73408 EnsemblBacteria BAE76089 http://www.ensemblgenomes.org/id/BAE76089 EnsemblBacteria BAE76089 http://www.ensemblgenomes.org/id/BAE76089 EnsemblBacteria BAE76089 http://www.ensemblgenomes.org/id/BAE76089 EnsemblBacteria b0305 http://www.ensemblgenomes.org/id/b0305 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000987 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000987 GO_function GO:0001216 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001216 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GO_process GO:0090347 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090347 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 Gene3D 2.60.120.10 http://www.cathdb.info/version/latest/superfamily/2.60.120.10 GeneID 945616 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945616 HOGENOM HOG000136816 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000136816&db=HOGENOM6 InParanoid P77379 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77379 IntAct P77379 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77379* InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR011051 http://www.ebi.ac.uk/interpro/entry/IPR011051 InterPro IPR014710 http://www.ebi.ac.uk/interpro/entry/IPR014710 InterPro IPR018060 http://www.ebi.ac.uk/interpro/entry/IPR018060 InterPro IPR020449 http://www.ebi.ac.uk/interpro/entry/IPR020449 InterPro IPR032783 http://www.ebi.ac.uk/interpro/entry/IPR032783 KEGG_Gene ecj:JW0298 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0298 KEGG_Gene eco:b0305 http://www.genome.jp/dbget-bin/www_bget?eco:b0305 OMA CMDFELG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CMDFELG PRINTS PR00032 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00032 PROSITE PS01124 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01124 PSORT swissprot:RCLR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RCLR_ECOLI PSORT-B swissprot:RCLR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RCLR_ECOLI PSORT2 swissprot:RCLR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RCLR_ECOLI Pfam PF12833 http://pfam.xfam.org/family/PF12833 Pfam PF12852 http://pfam.xfam.org/family/PF12852 Phobius swissprot:RCLR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RCLR_ECOLI PhylomeDB P77379 http://phylomedb.org/?seqid=P77379 ProteinModelPortal P77379 http://www.proteinmodelportal.org/query/uniprot/P77379 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 24078635 http://www.ncbi.nlm.nih.gov/pubmed/24078635 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414839 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414839 RefSeq WP_000339594 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000339594 SMART SM00342 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00342 SMR P77379 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77379 STRING 511145.b0305 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0305&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF51182 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51182 UniProtKB RCLR_ECOLI http://www.uniprot.org/uniprot/RCLR_ECOLI UniProtKB-AC P77379 http://www.uniprot.org/uniprot/P77379 charge swissprot:RCLR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RCLR_ECOLI eggNOG COG2207 http://eggnogapi.embl.de/nog_data/html/tree/COG2207 eggNOG ENOG4108K01 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108K01 epestfind swissprot:RCLR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RCLR_ECOLI garnier swissprot:RCLR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RCLR_ECOLI helixturnhelix swissprot:RCLR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RCLR_ECOLI hmoment swissprot:RCLR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RCLR_ECOLI iep swissprot:RCLR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RCLR_ECOLI inforesidue swissprot:RCLR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RCLR_ECOLI octanol swissprot:RCLR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RCLR_ECOLI pepcoil swissprot:RCLR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RCLR_ECOLI pepdigest swissprot:RCLR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RCLR_ECOLI pepinfo swissprot:RCLR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RCLR_ECOLI pepnet swissprot:RCLR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RCLR_ECOLI pepstats swissprot:RCLR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RCLR_ECOLI pepwheel swissprot:RCLR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RCLR_ECOLI pepwindow swissprot:RCLR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RCLR_ECOLI sigcleave swissprot:RCLR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RCLR_ECOLI ## Database ID URL or Descriptions # BioGrid 4261443 17 # EcoGene EG13104 ygbJ # GO_function GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity; IEA:InterPro. # GO_function GO:0051287 NAD binding; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # Gene3D 1.10.1040.10 -; 1. # Gene3D 3.40.50.720 -; 1. # IntAct Q46888 3 # InterPro IPR002204 3-OH-isobutyrate_DH-rel_CS # InterPro IPR006115 6PGDH_NADP-bd # InterPro IPR008927 6-PGluconate_DH_C-like # InterPro IPR013328 6PGD_dom_2 # InterPro IPR015815 HIBADH-related # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR029154 NADP-bd # KEGG_Brite ko01000 Enzymes # Organism YGBJ_ECOLI Escherichia coli (strain K12) # PATRIC 32120874 VBIEscCol129921_2829 # PIR D65054 D65054 # PIRSF PIRSF000103 HIBADH # PROSITE PS00895 3_HYDROXYISOBUT_DH # Pfam PF03446 NAD_binding_2 # Pfam PF14833 NAD_binding_11 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGBJ_ECOLI Uncharacterized oxidoreductase YgbJ # RefSeq NP_417216 NC_000913.3 # RefSeq WP_000848004 NZ_LN832404.1 # SIMILARITY Belongs to the 3-hydroxyisobutyrate dehydrogenase family. {ECO 0000305}. # SUPFAM SSF48179 SSF48179 # SUPFAM SSF51735 SSF51735 # eggNOG COG2084 LUCA # eggNOG ENOG4105ZXK Bacteria BLAST swissprot:YGBJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGBJ_ECOLI BioCyc ECOL316407:JW2706-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2706-MONOMER BioCyc EcoCyc:G7417-MONOMER http://biocyc.org/getid?id=EcoCyc:G7417-MONOMER COG COG2084 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2084 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.1.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 ENZYME 1.1.-.- http://enzyme.expasy.org/EC/1.1.-.- EchoBASE EB2907 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2907 EcoGene EG13104 http://www.ecogene.org/geneInfo.php?eg_id=EG13104 EnsemblBacteria AAC75778 http://www.ensemblgenomes.org/id/AAC75778 EnsemblBacteria AAC75778 http://www.ensemblgenomes.org/id/AAC75778 EnsemblBacteria BAE76813 http://www.ensemblgenomes.org/id/BAE76813 EnsemblBacteria BAE76813 http://www.ensemblgenomes.org/id/BAE76813 EnsemblBacteria BAE76813 http://www.ensemblgenomes.org/id/BAE76813 EnsemblBacteria b2736 http://www.ensemblgenomes.org/id/b2736 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004616 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004616 GO_function GO:0051287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051287 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 Gene3D 1.10.1040.10 http://www.cathdb.info/version/latest/superfamily/1.10.1040.10 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 947200 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947200 HOGENOM HOG000219608 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219608&db=HOGENOM6 InParanoid Q46888 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46888 IntAct Q46888 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46888* IntEnz 1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1 InterPro IPR002204 http://www.ebi.ac.uk/interpro/entry/IPR002204 InterPro IPR006115 http://www.ebi.ac.uk/interpro/entry/IPR006115 InterPro IPR008927 http://www.ebi.ac.uk/interpro/entry/IPR008927 InterPro IPR013328 http://www.ebi.ac.uk/interpro/entry/IPR013328 InterPro IPR015815 http://www.ebi.ac.uk/interpro/entry/IPR015815 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR029154 http://www.ebi.ac.uk/interpro/entry/IPR029154 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2706 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2706 KEGG_Gene eco:b2736 http://www.genome.jp/dbget-bin/www_bget?eco:b2736 KEGG_Orthology KO:K08319 http://www.genome.jp/dbget-bin/www_bget?KO:K08319 OMA AVIKIFP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AVIKIFP PROSITE PS00895 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00895 PSORT swissprot:YGBJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGBJ_ECOLI PSORT-B swissprot:YGBJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGBJ_ECOLI PSORT2 swissprot:YGBJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGBJ_ECOLI Pfam PF03446 http://pfam.xfam.org/family/PF03446 Pfam PF14833 http://pfam.xfam.org/family/PF14833 Phobius swissprot:YGBJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGBJ_ECOLI PhylomeDB Q46888 http://phylomedb.org/?seqid=Q46888 ProteinModelPortal Q46888 http://www.proteinmodelportal.org/query/uniprot/Q46888 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417216 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417216 RefSeq WP_000848004 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000848004 SMR Q46888 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46888 STRING 511145.b2736 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2736&targetmode=cogs STRING COG2084 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2084&targetmode=cogs SUPFAM SSF48179 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48179 SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB YGBJ_ECOLI http://www.uniprot.org/uniprot/YGBJ_ECOLI UniProtKB-AC Q46888 http://www.uniprot.org/uniprot/Q46888 charge swissprot:YGBJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGBJ_ECOLI eggNOG COG2084 http://eggnogapi.embl.de/nog_data/html/tree/COG2084 eggNOG ENOG4105ZXK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ZXK epestfind swissprot:YGBJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGBJ_ECOLI garnier swissprot:YGBJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGBJ_ECOLI helixturnhelix swissprot:YGBJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGBJ_ECOLI hmoment swissprot:YGBJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGBJ_ECOLI iep swissprot:YGBJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGBJ_ECOLI inforesidue swissprot:YGBJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGBJ_ECOLI octanol swissprot:YGBJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGBJ_ECOLI pepcoil swissprot:YGBJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGBJ_ECOLI pepdigest swissprot:YGBJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGBJ_ECOLI pepinfo swissprot:YGBJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGBJ_ECOLI pepnet swissprot:YGBJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGBJ_ECOLI pepstats swissprot:YGBJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGBJ_ECOLI pepwheel swissprot:YGBJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGBJ_ECOLI pepwindow swissprot:YGBJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGBJ_ECOLI sigcleave swissprot:YGBJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGBJ_ECOLI ## Database ID URL or Descriptions # AltName NARW_ECOLI Redox enzyme maturation protein NarW # BioGrid 4260181 191 # EcoGene EG10645 narW # FUNCTION NARW_ECOLI Chaperone required for proper molybdenum cofactor insertion and final assembly of the membrane-bound respiratory nitrate reductase 2. {ECO 0000250}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0016530 metallochaperone activity; IBA:GO_Central. # GO_process GO:0042128 nitrate assimilation; IBA:GO_Central. # GO_process GO:0051131 chaperone-mediated protein complex assembly; IBA:GO_Central. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0071941 nitrogen cycle metabolic process # INTERACTION NARW_ECOLI P09152 narG; NbExp=7; IntAct=EBI-555088, EBI-547248; P19318 narY; NbExp=3; IntAct=EBI-555088, EBI-555059; P19319 narZ; NbExp=3; IntAct=EBI-555088, EBI-547262; # IntAct P19317 8 # InterPro IPR003765 NO3_reductase_chaperone_NarJ # InterPro IPR020945 DMSO/NO3_reduct_chaperone # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Pathway ko00910 Nitrogen metabolism # Organism NARW_ECOLI Escherichia coli (strain K12) # PATRIC 32118224 VBIEscCol129921_1532 # PIR S11429 S11429 # Pfam PF02613 Nitrate_red_del # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NARW_ECOLI Probable nitrate reductase molybdenum cofactor assembly chaperone NarW # RefSeq NP_415983 NC_000913.3 # RefSeq WP_001166353 NZ_LN832404.1 # SIMILARITY Belongs to the NarJ/NarW family. {ECO 0000305}. # SUBCELLULAR LOCATION NARW_ECOLI Cytoplasm {ECO 0000250}. # SUPFAM SSF89155 SSF89155 # TIGRFAMs TIGR00684 narJ # eggNOG COG2180 LUCA # eggNOG ENOG4108NZN Bacteria BLAST swissprot:NARW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NARW_ECOLI BioCyc ECOL316407:JW1461-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1461-MONOMER BioCyc EcoCyc:NARW-MONOMER http://biocyc.org/getid?id=EcoCyc:NARW-MONOMER COG COG2180 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2180 DIP DIP-10321N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10321N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X17110 http://www.ebi.ac.uk/ena/data/view/X17110 EchoBASE EB0639 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0639 EcoGene EG10645 http://www.ecogene.org/geneInfo.php?eg_id=EG10645 EnsemblBacteria AAC74548 http://www.ensemblgenomes.org/id/AAC74548 EnsemblBacteria AAC74548 http://www.ensemblgenomes.org/id/AAC74548 EnsemblBacteria BAA15103 http://www.ensemblgenomes.org/id/BAA15103 EnsemblBacteria BAA15103 http://www.ensemblgenomes.org/id/BAA15103 EnsemblBacteria BAA15103 http://www.ensemblgenomes.org/id/BAA15103 EnsemblBacteria b1466 http://www.ensemblgenomes.org/id/b1466 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0016530 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016530 GO_process GO:0042128 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042128 GO_process GO:0051131 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051131 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0071941 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071941 GeneID 946032 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946032 HOGENOM HOG000237365 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000237365&db=HOGENOM6 InParanoid P19317 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P19317 IntAct P19317 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P19317* InterPro IPR003765 http://www.ebi.ac.uk/interpro/entry/IPR003765 InterPro IPR020945 http://www.ebi.ac.uk/interpro/entry/IPR020945 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Gene ecj:JW1461 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1461 KEGG_Gene eco:b1466 http://www.genome.jp/dbget-bin/www_bget?eco:b1466 KEGG_Orthology KO:K08361 http://www.genome.jp/dbget-bin/www_bget?KO:K08361 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Reaction rn:R00798 http://www.genome.jp/dbget-bin/www_bget?rn:R00798 KEGG_Reaction rn:R01106 http://www.genome.jp/dbget-bin/www_bget?rn:R01106 MINT MINT-1251853 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1251853 OMA SVTKQIR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SVTKQIR PSORT swissprot:NARW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NARW_ECOLI PSORT-B swissprot:NARW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NARW_ECOLI PSORT2 swissprot:NARW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NARW_ECOLI Pfam PF02613 http://pfam.xfam.org/family/PF02613 Phobius swissprot:NARW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NARW_ECOLI PhylomeDB P19317 http://phylomedb.org/?seqid=P19317 ProteinModelPortal P19317 http://www.proteinmodelportal.org/query/uniprot/P19317 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2233673 http://www.ncbi.nlm.nih.gov/pubmed/2233673 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415983 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415983 RefSeq WP_001166353 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001166353 SMR P19317 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P19317 STRING 511145.b1466 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1466&targetmode=cogs STRING COG2180 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2180&targetmode=cogs SUPFAM SSF89155 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF89155 TIGRFAMs TIGR00684 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00684 UniProtKB NARW_ECOLI http://www.uniprot.org/uniprot/NARW_ECOLI UniProtKB-AC P19317 http://www.uniprot.org/uniprot/P19317 charge swissprot:NARW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NARW_ECOLI eggNOG COG2180 http://eggnogapi.embl.de/nog_data/html/tree/COG2180 eggNOG ENOG4108NZN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108NZN epestfind swissprot:NARW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NARW_ECOLI garnier swissprot:NARW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NARW_ECOLI helixturnhelix swissprot:NARW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NARW_ECOLI hmoment swissprot:NARW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NARW_ECOLI iep swissprot:NARW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NARW_ECOLI inforesidue swissprot:NARW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NARW_ECOLI octanol swissprot:NARW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NARW_ECOLI pepcoil swissprot:NARW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NARW_ECOLI pepdigest swissprot:NARW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NARW_ECOLI pepinfo swissprot:NARW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NARW_ECOLI pepnet swissprot:NARW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NARW_ECOLI pepstats swissprot:NARW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NARW_ECOLI pepwheel swissprot:NARW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NARW_ECOLI pepwindow swissprot:NARW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NARW_ECOLI sigcleave swissprot:NARW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NARW_ECOLI ## Database ID URL or Descriptions # BioGrid 4263202 11 # EcoGene EG10452 hisP # FUNCTION HISP_ECOLI Part of the histidine permease ABC transporter. Also part of a lysine/arginine/ornithine transporter. Responsible for energy coupling to the transport system (By similarity). {ECO 0000250}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0015424 amino acid-transporting ATPase activity; IEA:InterPro. # GO_process GO:0015817 histidine transport; ISA:EcoliWiki. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # Gene3D 3.40.50.300 -; 1. # IntAct P07109 5 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # InterPro IPR030679 ABC_ATPase_HisP-typ # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00225 Lysine/arginine/ornithine transport system # KEGG_Brite ko02000 M00226 Histidine transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism HISP_ECOLI Escherichia coli (strain K12) # PATRIC 32119983 VBIEscCol129921_2401 # PIR H65002 H65002 # PIRSF PIRSF039085 ABC_ATPase_HisP # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # Pfam PF00005 ABC_tran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HISP_ECOLI Histidine transport ATP-binding protein HisP # RefSeq NP_416809 NC_000913.3 # RefSeq WP_001293613 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA # SUBCELLULAR LOCATION HISP_ECOLI Cell inner membrane; Peripheral membrane protein. # SUBUNIT The complex is composed of two ATP-binding proteins (HisP), two transmembrane proteins (HisM and HisQ) and a solute- binding protein (HisJ or ArgT). {ECO 0000250}. # SUPFAM SSF52540 SSF52540 # TCDB 3.A.1.3.29 the atp-binding cassette (abc) superfamily # eggNOG COG4598 LUCA # eggNOG ENOG4108JEH Bacteria BLAST swissprot:HISP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HISP_ECOLI BioCyc ECOL316407:JW2303-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2303-MONOMER BioCyc EcoCyc:HISP-MONOMER http://biocyc.org/getid?id=EcoCyc:HISP-MONOMER COG COG4598 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4598 DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/nar/15.20.8568 http://dx.doi.org/10.1093/nar/15.20.8568 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL Y00455 http://www.ebi.ac.uk/ena/data/view/Y00455 EchoBASE EB0447 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0447 EcoGene EG10452 http://www.ecogene.org/geneInfo.php?eg_id=EG10452 EnsemblBacteria AAC75366 http://www.ensemblgenomes.org/id/AAC75366 EnsemblBacteria AAC75366 http://www.ensemblgenomes.org/id/AAC75366 EnsemblBacteria BAA16143 http://www.ensemblgenomes.org/id/BAA16143 EnsemblBacteria BAA16143 http://www.ensemblgenomes.org/id/BAA16143 EnsemblBacteria BAA16143 http://www.ensemblgenomes.org/id/BAA16143 EnsemblBacteria b2306 http://www.ensemblgenomes.org/id/b2306 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0015424 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015424 GO_process GO:0015817 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015817 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 946789 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946789 InParanoid P07109 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P07109 IntAct P07109 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P07109* InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR030679 http://www.ebi.ac.uk/interpro/entry/IPR030679 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2303 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2303 KEGG_Gene eco:b2306 http://www.genome.jp/dbget-bin/www_bget?eco:b2306 KEGG_Orthology KO:K10017 http://www.genome.jp/dbget-bin/www_bget?KO:K10017 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA KPDQIFD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KPDQIFD PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:HISP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HISP_ECOLI PSORT-B swissprot:HISP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HISP_ECOLI PSORT2 swissprot:HISP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HISP_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Phobius swissprot:HISP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HISP_ECOLI PhylomeDB P07109 http://phylomedb.org/?seqid=P07109 ProteinModelPortal P07109 http://www.proteinmodelportal.org/query/uniprot/P07109 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2246240 http://www.ncbi.nlm.nih.gov/pubmed/2246240 PubMed 3313284 http://www.ncbi.nlm.nih.gov/pubmed/3313284 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_416809 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416809 RefSeq WP_001293613 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001293613 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P07109 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P07109 STRING 511145.b2306 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2306&targetmode=cogs STRING COG4598 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4598&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.3.29 http://www.tcdb.org/search/result.php?tc=3.A.1.3.29 UniProtKB HISP_ECOLI http://www.uniprot.org/uniprot/HISP_ECOLI UniProtKB-AC P07109 http://www.uniprot.org/uniprot/P07109 charge swissprot:HISP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HISP_ECOLI eggNOG COG4598 http://eggnogapi.embl.de/nog_data/html/tree/COG4598 eggNOG ENOG4108JEH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108JEH epestfind swissprot:HISP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HISP_ECOLI garnier swissprot:HISP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HISP_ECOLI helixturnhelix swissprot:HISP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HISP_ECOLI hmoment swissprot:HISP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HISP_ECOLI iep swissprot:HISP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HISP_ECOLI inforesidue swissprot:HISP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HISP_ECOLI octanol swissprot:HISP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HISP_ECOLI pepcoil swissprot:HISP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HISP_ECOLI pepdigest swissprot:HISP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HISP_ECOLI pepinfo swissprot:HISP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HISP_ECOLI pepnet swissprot:HISP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HISP_ECOLI pepstats swissprot:HISP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HISP_ECOLI pepwheel swissprot:HISP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HISP_ECOLI pepwindow swissprot:HISP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HISP_ECOLI sigcleave swissprot:HISP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HISP_ECOLI ## Database ID URL or Descriptions # AltName L-allo-threonine dehydrogenase {ECO:0000303|PubMed 12535615} # AltName Malonic semialdehyde reductase {ECO:0000303|PubMed 20400551} # BIOPHYSICOCHEMICAL PROPERTIES YDFG_ECOLI Kinetic parameters KM=0.54 mM for NADP(+) (at pH 9 and at 30 degrees Celsius) {ECO 0000269|PubMed 12535615}; KM=40 mM for L-serine (at pH 9 and at 30 degrees Celsius) {ECO 0000269|PubMed 12535615}; KM=69 mM for D-serine (at pH 9 and at 30 degrees Celsius) {ECO 0000269|PubMed 12535615}; KM=60 mM for D-threonine (at pH 9 and at 30 degrees Celsius) {ECO 0000269|PubMed 12535615}; KM=29 mM for L-allo-threonine (at pH 9 and at 30 degrees Celsius) {ECO 0000269|PubMed 12535615}; KM=33 mM for L-glycerate (at pH 9 and at 30 degrees Celsius) {ECO 0000269|PubMed 12535615}; KM=50 mM for D-glycerate (at pH 9 and at 30 degrees Celsius) {ECO 0000269|PubMed 12535615}; KM=60 mM for L-3-hydroxyisobutyrate (at pH 9 and at 30 degrees Celsius) {ECO 0000269|PubMed 12535615}; KM=61 mM for D-3-hydroxyisobutyrate (at pH 9 and at 30 degrees Celsius) {ECO 0000269|PubMed 12535615}; Note=The highest catalytic efficiency was observed with L-allo- threonine. {ECO 0000269|PubMed 12535615}; pH dependence Optimum pH is about 8.5 for the oxidation of L-serine. Stable from pH 6.5 to 10.0. {ECO 0000269|PubMed 12535615}; Temperature dependence Still active after heating at 55 degrees Celsius for 80 minutes. {ECO 0000269|PubMed 12535615}; # BioGrid 4261740 16 # CATALYTIC ACTIVITY 3-hydroxypropanoate + NADP(+) = 3- oxopropanoate + NADPH. {ECO:0000269|PubMed 20400551}. # CATALYTIC ACTIVITY L-allo-threonine + NADP(+) = aminoacetone + CO(2) + NADPH. {ECO:0000269|PubMed 12535615}. # DISRUPTION PHENOTYPE Cells lacking this gene grow poorly on pyrimidine nucleosides and bases as the sole source of nitrogen at room temperature indicating a probably accumulation of a toxic intermediate, the malonic semialdehyde. {ECO:0000269|PubMed 20400551}. # EcoGene EG12345 ydfG # FUNCTION YDFG_ECOLI NADP-dependent dehydrogenase with broad substrate specificity acting on 3-hydroxy acids. Catalyzes the NADP- dependent oxidation of L-allo-threonine to L-2-amino-3-keto- butyrate, which is spontaneously decarboxylated into aminoacetone. Also acts on D-threonine, L-serine, D-serine, D-3- hydroxyisobutyrate, L-3-hydroxyisobutyrate, D-glycerate and L- glycerate (PubMed 12535615). Able to catalyze the reduction of the malonic semialdehyde to 3-hydroxypropionic acid. YdfG is apparently supplementing RutE, the presumed malonic semialdehyde reductase involved in pyrimidine degradation since both are able to detoxify malonic semialdehyde (PubMed 20400551). {ECO 0000269|PubMed 12535615, ECO 0000269|PubMed 20400551}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0031132 serine 3-dehydrogenase activity; IDA:EcoCyc. # GO_function GO:0035527 3-hydroxypropionate dehydrogenase (NADP+) activity; IDA:EcoCyc. # GO_process GO:0006212 uracil catabolic process; IDA:UniProtKB. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.720 -; 1. # IntAct P39831 9 # InterPro IPR002347 SDR_fam # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR020904 Sc_DH/Rdtase_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00240 Pyrimidine metabolism # MISCELLANEOUS YDFG_ECOLI L-threonine, D-allo-threonine, DL-threo-3-phenyl- serine, malonate, DL-malate, citrate, isocitrate, DL-lactate, DL- tartrate, gluconate, glycerol and glycolate are inert as substrates. # Organism YDFG_ECOLI Escherichia coli (strain K12) # PANTHER PTHR24322 PTHR24322; 2 # PATRIC 32118378 VBIEscCol129921_1609 # PIR F64908 F64908 # PRINTS PR00080 SDRFAMILY # PRINTS PR00081 GDHRDH # PROSITE PS00061 ADH_SHORT # Pfam PF00106 adh_short # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NADP-dependent 3-hydroxy acid dehydrogenase YdfG {ECO:0000303|PubMed 12535615} # RefSeq NP_416057 NC_000913.3 # RefSeq WP_000636571 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=X57947; Type=Frameshift; Positions=58; Evidence={ECO 0000305}; # SIMILARITY Belongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO 0000305}. # SUBUNIT Homotetramer. {ECO:0000269|PubMed 12535615}. # SUPFAM SSF51735 SSF51735 # eggNOG COG4221 LUCA # eggNOG ENOG4105EMU Bacteria BLAST swissprot:YDFG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDFG_ECOLI BioCyc ECOL316407:JW1532-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1532-MONOMER BioCyc EcoCyc:EG12345-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12345-MONOMER BioCyc MetaCyc:EG12345-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12345-MONOMER COG COG4221 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4221 DIP DIP-11696N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11696N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1016/S1570-9639(02)00533-2 http://dx.doi.org/10.1016/S1570-9639(02)00533-2 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00201-10 http://dx.doi.org/10.1128/JB.00201-10 EC_number EC:1.1.1.298 {ECO:0000305|PubMed:20400551} http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.298 {ECO:0000305|PubMed:20400551} EC_number EC:1.1.1.381 {ECO:0000269|PubMed:12535615} http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.381 {ECO:0000269|PubMed:12535615} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X57947 http://www.ebi.ac.uk/ena/data/view/X57947 ENZYME 1.1.1.298 {ECO:0000305|PubMed:20400551} http://enzyme.expasy.org/EC/1.1.1.298 {ECO:0000305|PubMed:20400551} ENZYME 1.1.1.381 {ECO:0000269|PubMed:12535615} http://enzyme.expasy.org/EC/1.1.1.381 {ECO:0000269|PubMed:12535615} EchoBASE EB2249 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2249 EcoGene EG12345 http://www.ecogene.org/geneInfo.php?eg_id=EG12345 EnsemblBacteria AAC74612 http://www.ensemblgenomes.org/id/AAC74612 EnsemblBacteria AAC74612 http://www.ensemblgenomes.org/id/AAC74612 EnsemblBacteria BAA15241 http://www.ensemblgenomes.org/id/BAA15241 EnsemblBacteria BAA15241 http://www.ensemblgenomes.org/id/BAA15241 EnsemblBacteria BAA15241 http://www.ensemblgenomes.org/id/BAA15241 EnsemblBacteria b1539 http://www.ensemblgenomes.org/id/b1539 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0031132 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031132 GO_function GO:0035527 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035527 GO_process GO:0006212 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006212 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 946085 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946085 InParanoid P39831 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39831 IntAct P39831 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39831* IntEnz 1.1.1.298 {ECO:0000305|PubMed:20400551} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.298 {ECO:0000305|PubMed:20400551} IntEnz 1.1.1.381 {ECO:0000269|PubMed:12535615} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.381 {ECO:0000269|PubMed:12535615} InterPro IPR002347 http://www.ebi.ac.uk/interpro/entry/IPR002347 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR020904 http://www.ebi.ac.uk/interpro/entry/IPR020904 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1532 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1532 KEGG_Gene eco:b1539 http://www.genome.jp/dbget-bin/www_bget?eco:b1539 KEGG_Orthology KO:K16066 http://www.genome.jp/dbget-bin/www_bget?KO:K16066 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Reaction rn:R09289 http://www.genome.jp/dbget-bin/www_bget?rn:R09289 OMA STAGNWP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=STAGNWP PANTHER PTHR24322 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24322 PRINTS PR00080 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00080 PRINTS PR00081 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00081 PROSITE PS00061 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00061 PSORT swissprot:YDFG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDFG_ECOLI PSORT-B swissprot:YDFG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDFG_ECOLI PSORT2 swissprot:YDFG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDFG_ECOLI Pfam PF00106 http://pfam.xfam.org/family/PF00106 Phobius swissprot:YDFG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDFG_ECOLI PhylomeDB P39831 http://phylomedb.org/?seqid=P39831 ProteinModelPortal P39831 http://www.proteinmodelportal.org/query/uniprot/P39831 PubMed 12535615 http://www.ncbi.nlm.nih.gov/pubmed/12535615 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20400551 http://www.ncbi.nlm.nih.gov/pubmed/20400551 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 8226676 http://www.ncbi.nlm.nih.gov/pubmed/8226676 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_416057 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416057 RefSeq WP_000636571 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000636571 SMR P39831 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39831 STRING 511145.b1539 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1539&targetmode=cogs STRING COG4221 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4221&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB YDFG_ECOLI http://www.uniprot.org/uniprot/YDFG_ECOLI UniProtKB-AC P39831 http://www.uniprot.org/uniprot/P39831 charge swissprot:YDFG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDFG_ECOLI eggNOG COG4221 http://eggnogapi.embl.de/nog_data/html/tree/COG4221 eggNOG ENOG4105EMU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EMU epestfind swissprot:YDFG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDFG_ECOLI garnier swissprot:YDFG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDFG_ECOLI helixturnhelix swissprot:YDFG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDFG_ECOLI hmoment swissprot:YDFG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDFG_ECOLI iep swissprot:YDFG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDFG_ECOLI inforesidue swissprot:YDFG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDFG_ECOLI octanol swissprot:YDFG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDFG_ECOLI pepcoil swissprot:YDFG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDFG_ECOLI pepdigest swissprot:YDFG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDFG_ECOLI pepinfo swissprot:YDFG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDFG_ECOLI pepnet swissprot:YDFG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDFG_ECOLI pepstats swissprot:YDFG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDFG_ECOLI pepwheel swissprot:YDFG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDFG_ECOLI pepwindow swissprot:YDFG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDFG_ECOLI sigcleave swissprot:YDFG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDFG_ECOLI ## Database ID URL or Descriptions # BioGrid 4260091 8 # EcoGene EG13445 ymfA # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR021994 DUF3592 # Organism YMFA_ECOLI Escherichia coli (strain K12) # PATRIC 32117491 VBIEscCol129921_1168 # PIR G64856 G64856 # Pfam PF12158 DUF3592 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YMFA_ECOLI Inner membrane protein YmfA # RefSeq NP_415640 NC_000913.3 # RefSeq WP_000076376 NZ_LN832404.1 # SUBCELLULAR LOCATION YMFA_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 9.B.122.1 the duf3592 or pf12158 (duf3592) family BLAST swissprot:YMFA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YMFA_ECOLI BioCyc ECOL316407:JW5164-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5164-MONOMER BioCyc EcoCyc:G6579-MONOMER http://biocyc.org/getid?id=EcoCyc:G6579-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3219 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3219 EcoGene EG13445 http://www.ecogene.org/geneInfo.php?eg_id=EG13445 EnsemblBacteria AAC74206 http://www.ensemblgenomes.org/id/AAC74206 EnsemblBacteria AAC74206 http://www.ensemblgenomes.org/id/AAC74206 EnsemblBacteria BAA35942 http://www.ensemblgenomes.org/id/BAA35942 EnsemblBacteria BAA35942 http://www.ensemblgenomes.org/id/BAA35942 EnsemblBacteria BAA35942 http://www.ensemblgenomes.org/id/BAA35942 EnsemblBacteria b1122 http://www.ensemblgenomes.org/id/b1122 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 945684 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945684 HOGENOM HOG000119107 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000119107&db=HOGENOM6 InterPro IPR021994 http://www.ebi.ac.uk/interpro/entry/IPR021994 KEGG_Gene ecj:JW5164 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5164 KEGG_Gene eco:b1122 http://www.genome.jp/dbget-bin/www_bget?eco:b1122 OMA DSAMINT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DSAMINT PSORT swissprot:YMFA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YMFA_ECOLI PSORT-B swissprot:YMFA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YMFA_ECOLI PSORT2 swissprot:YMFA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YMFA_ECOLI Pfam PF12158 http://pfam.xfam.org/family/PF12158 Phobius swissprot:YMFA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YMFA_ECOLI ProteinModelPortal P75962 http://www.proteinmodelportal.org/query/uniprot/P75962 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415640 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415640 RefSeq WP_000076376 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000076376 STRING 511145.b1122 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1122&targetmode=cogs TCDB 9.B.122.1 http://www.tcdb.org/search/result.php?tc=9.B.122.1 UniProtKB YMFA_ECOLI http://www.uniprot.org/uniprot/YMFA_ECOLI UniProtKB-AC P75962 http://www.uniprot.org/uniprot/P75962 charge swissprot:YMFA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YMFA_ECOLI epestfind swissprot:YMFA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YMFA_ECOLI garnier swissprot:YMFA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YMFA_ECOLI helixturnhelix swissprot:YMFA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YMFA_ECOLI hmoment swissprot:YMFA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YMFA_ECOLI iep swissprot:YMFA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YMFA_ECOLI inforesidue swissprot:YMFA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YMFA_ECOLI octanol swissprot:YMFA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YMFA_ECOLI pepcoil swissprot:YMFA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YMFA_ECOLI pepdigest swissprot:YMFA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YMFA_ECOLI pepinfo swissprot:YMFA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YMFA_ECOLI pepnet swissprot:YMFA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YMFA_ECOLI pepstats swissprot:YMFA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YMFA_ECOLI pepwheel swissprot:YMFA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YMFA_ECOLI pepwindow swissprot:YMFA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YMFA_ECOLI sigcleave swissprot:YMFA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YMFA_ECOLI ## Database ID URL or Descriptions # AltName MRR_ECOLI EcoKMrr # BioGrid 4262770 56 # EcoGene EG10612 mrr # FUNCTION MRR_ECOLI Involved in the acceptance of foreign DNA which is modified. Restricts both adenine- and cytosine-methylated DNA. # GO_component GO:0043590 bacterial nucleoid; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_function GO:0015666 restriction endodeoxyribonuclease activity; IMP:EcoCyc. # GO_function GO:0032067 Type IV site-specific deoxyribonuclease activity; IDA:EcoCyc. # GO_process GO:0009307 DNA restriction-modification system; IEA:UniProtKB-KW. # GO_process GO:0051599 response to hydrostatic pressure; IMP:EcoCyc. # GOslim_component GO:0043226 organelle # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004518 nuclease activity # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # Gene3D 3.40.1350.10 -; 1. # InterPro IPR007560 Restrct_endonuc_IV_Mrr # InterPro IPR011335 Restrct_endonuc-II-like # InterPro IPR011856 tRNA_endonuc-like_dom # InterPro IPR025745 Mrr-like_N_dom # Organism MRR_ECOLI Escherichia coli (strain K12) # PATRIC 32124308 VBIEscCol129921_4497 # PIR A40368 A40368 # Pfam PF04471 Mrr_cat # Pfam PF14338 Mrr_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # REBASE 2906 EcoKMrr # RecName MRR_ECOLI Mrr restriction system protein # RefSeq NP_418771 NC_000913.3 # RefSeq WP_000217931 NZ_LN832404.1 # SUPFAM SSF52980 SSF52980 # eggNOG COG1715 LUCA # eggNOG ENOG4106H3A Bacteria BLAST swissprot:MRR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MRR_ECOLI BioCyc ECOL316407:JW4314-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4314-MONOMER BioCyc EcoCyc:EG10612-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10612-MONOMER COG COG1715 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1715 DIP DIP-10259N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10259N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X54198 http://www.ebi.ac.uk/ena/data/view/X54198 EchoBASE EB0607 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0607 EcoGene EG10612 http://www.ecogene.org/geneInfo.php?eg_id=EG10612 EnsemblBacteria AAC77307 http://www.ensemblgenomes.org/id/AAC77307 EnsemblBacteria AAC77307 http://www.ensemblgenomes.org/id/AAC77307 EnsemblBacteria BAE78341 http://www.ensemblgenomes.org/id/BAE78341 EnsemblBacteria BAE78341 http://www.ensemblgenomes.org/id/BAE78341 EnsemblBacteria BAE78341 http://www.ensemblgenomes.org/id/BAE78341 EnsemblBacteria b4351 http://www.ensemblgenomes.org/id/b4351 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0043590 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043590 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0015666 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015666 GO_function GO:0032067 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032067 GO_process GO:0009307 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009307 GO_process GO:0051599 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051599 GOslim_component GO:0043226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.40.1350.10 http://www.cathdb.info/version/latest/superfamily/3.40.1350.10 GeneID 948898 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948898 HOGENOM HOG000015253 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000015253&db=HOGENOM6 InParanoid P24202 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P24202 IntAct P24202 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P24202* InterPro IPR007560 http://www.ebi.ac.uk/interpro/entry/IPR007560 InterPro IPR011335 http://www.ebi.ac.uk/interpro/entry/IPR011335 InterPro IPR011856 http://www.ebi.ac.uk/interpro/entry/IPR011856 InterPro IPR025745 http://www.ebi.ac.uk/interpro/entry/IPR025745 KEGG_Gene ecj:JW4314 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4314 KEGG_Gene eco:b4351 http://www.genome.jp/dbget-bin/www_bget?eco:b4351 KEGG_Orthology KO:K07448 http://www.genome.jp/dbget-bin/www_bget?KO:K07448 MINT MINT-1267575 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1267575 OMA VIYIQAK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VIYIQAK PSORT swissprot:MRR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MRR_ECOLI PSORT-B swissprot:MRR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MRR_ECOLI PSORT2 swissprot:MRR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MRR_ECOLI Pfam PF04471 http://pfam.xfam.org/family/PF04471 Pfam PF14338 http://pfam.xfam.org/family/PF14338 Phobius swissprot:MRR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MRR_ECOLI PhylomeDB P24202 http://phylomedb.org/?seqid=P24202 ProteinModelPortal P24202 http://www.proteinmodelportal.org/query/uniprot/P24202 PubMed 1650347 http://www.ncbi.nlm.nih.gov/pubmed/1650347 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 REBASE 2906 http://rebase.neb.com/rebase/enz/2906.html RefSeq NP_418771 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418771 RefSeq WP_000217931 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000217931 SMR P24202 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P24202 STRING 511145.b4351 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4351&targetmode=cogs STRING COG1715 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1715&targetmode=cogs SUPFAM SSF52980 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52980 UniProtKB MRR_ECOLI http://www.uniprot.org/uniprot/MRR_ECOLI UniProtKB-AC P24202 http://www.uniprot.org/uniprot/P24202 charge swissprot:MRR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MRR_ECOLI eggNOG COG1715 http://eggnogapi.embl.de/nog_data/html/tree/COG1715 eggNOG ENOG4106H3A http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106H3A epestfind swissprot:MRR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MRR_ECOLI garnier swissprot:MRR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MRR_ECOLI helixturnhelix swissprot:MRR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MRR_ECOLI hmoment swissprot:MRR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MRR_ECOLI iep swissprot:MRR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MRR_ECOLI inforesidue swissprot:MRR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MRR_ECOLI octanol swissprot:MRR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MRR_ECOLI pepcoil swissprot:MRR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MRR_ECOLI pepdigest swissprot:MRR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MRR_ECOLI pepinfo swissprot:MRR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MRR_ECOLI pepnet swissprot:MRR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MRR_ECOLI pepstats swissprot:MRR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MRR_ECOLI pepwheel swissprot:MRR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MRR_ECOLI pepwindow swissprot:MRR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MRR_ECOLI sigcleave swissprot:MRR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MRR_ECOLI ## Database ID URL or Descriptions # AltName IROK_ECOLI 3-hydroxypropionic acid resistance peptide # CAUTION Encoded by the 21 C-terminal amino acids of the HcaR transcriptional activator, it is suggested to be produced by an independent promoter within the hcaR gene. However the peptide's existence has not been proven, nor has mutagenesis of HcaR itself rather than overexpression of IroK been ruled out as the cause of 3-HP resistance. {ECO 0000305}. # EcoGene EG14501 iroK # FUNCTION IROK_ECOLI Possible increased expression of this protein (due to mutations upstream of the start codon) is proposed to be responsible for resistance to 3-hydroxypropionic acid (3-HP). {ECO 0000269|PubMed 22161628}. # MISCELLANEOUS Mutagenesis of the start codon from ATG to TTG, which should decrease protein expression, results in loss of 3-HP resistance. {ECO:0000305|PubMed 22161628}. # Organism IROK_ECOLI Escherichia coli (strain K12) # Proteomes UP000000625 Chromosome # RecName IROK_ECOLI Protein IroK # RefSeq YP_008592385 NC_000913.3 # eggNOG ENOG4108W5M Bacteria # eggNOG ENOG4111IYC LUCA BLAST swissprot:IROK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:IROK_ECOLI BioCyc EcoCyc:MONOMER0-4224 http://biocyc.org/getid?id=EcoCyc:MONOMER0-4224 DOI 10.1002/bit.24398 http://dx.doi.org/10.1002/bit.24398 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14501 http://www.ecogene.org/geneInfo.php?eg_id=EG14501 EnsemblBacteria AGW80435 http://www.ensemblgenomes.org/id/AGW80435 EnsemblBacteria AGW80435 http://www.ensemblgenomes.org/id/AGW80435 EnsemblBacteria b4706 http://www.ensemblgenomes.org/id/b4706 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 14678510 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14678510 KEGG_Gene eco:b4706 http://www.genome.jp/dbget-bin/www_bget?eco:b4706 PSORT swissprot:IROK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:IROK_ECOLI PSORT-B swissprot:IROK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:IROK_ECOLI PSORT2 swissprot:IROK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:IROK_ECOLI Phobius swissprot:IROK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:IROK_ECOLI PubMed 22161628 http://www.ncbi.nlm.nih.gov/pubmed/22161628 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq YP_008592385 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_008592385 STRING 511145.b2537 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2537&targetmode=cogs UniProtKB IROK_ECOLI http://www.uniprot.org/uniprot/IROK_ECOLI UniProtKB-AC U3PVA8 http://www.uniprot.org/uniprot/U3PVA8 charge swissprot:IROK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:IROK_ECOLI eggNOG ENOG4108W5M http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108W5M eggNOG ENOG4111IYC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111IYC epestfind swissprot:IROK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:IROK_ECOLI garnier swissprot:IROK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:IROK_ECOLI helixturnhelix swissprot:IROK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:IROK_ECOLI hmoment swissprot:IROK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:IROK_ECOLI iep swissprot:IROK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:IROK_ECOLI inforesidue swissprot:IROK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:IROK_ECOLI octanol swissprot:IROK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:IROK_ECOLI pepcoil swissprot:IROK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:IROK_ECOLI pepdigest swissprot:IROK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:IROK_ECOLI pepinfo swissprot:IROK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:IROK_ECOLI pepnet swissprot:IROK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:IROK_ECOLI pepstats swissprot:IROK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:IROK_ECOLI pepwheel swissprot:IROK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:IROK_ECOLI pepwindow swissprot:IROK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:IROK_ECOLI sigcleave swissprot:IROK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:IROK_ECOLI ## Database ID URL or Descriptions # AltName HYCC_ECOLI Hydrogenase-3 component C # BioGrid 4262104 5 # EcoGene EG10476 hycC # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0008137 NADH dehydrogenase (ubiquinone) activity; IEA:InterPro. # GO_process GO:0042773 ATP synthesis coupled electron transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006091 generation of precursor metabolites and energy # IntAct P16429 2 # InterPro IPR001750 ND/Mrp_mem # InterPro IPR003918 NADH_UbQ_OxRdtase # Organism HYCC_ECOLI Escherichia coli (strain K12) # PATRIC 32120846 VBIEscCol129921_2815 # PIR G65052 G65052 # PRINTS PR01437 NUOXDRDTASE4 # Pfam PF00361 Proton_antipo_M # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HYCC_ECOLI Formate hydrogenlyase subunit 3 # RefSeq NP_417203 NC_000913.3 # RefSeq WP_001274396 NZ_LN832404.1 # SIMILARITY Belongs to the complex I subunit 4 family. {ECO 0000305}. # SUBCELLULAR LOCATION HYCC_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # SUBUNIT HYCC_ECOLI FHL comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (isoenzyme 3). In this non- energy conserving pathway molecular hydrogen and carbodioxide from formate are released. # TCDB 3.D.1.9 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family # eggNOG COG0651 LUCA # eggNOG ENOG4107R30 Bacteria BLAST swissprot:HYCC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HYCC_ECOLI BioCyc ECOL316407:JW2693-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2693-MONOMER BioCyc EcoCyc:HYCC-MONOMER http://biocyc.org/getid?id=EcoCyc:HYCC-MONOMER BioCyc MetaCyc:HYCC-MONOMER http://biocyc.org/getid?id=MetaCyc:HYCC-MONOMER COG COG0651 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0651 DIP DIP-9973N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9973N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1990.tb00590.x http://dx.doi.org/10.1111/j.1365-2958.1990.tb00590.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EMBL X17506 http://www.ebi.ac.uk/ena/data/view/X17506 EchoBASE EB0471 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0471 EcoGene EG10476 http://www.ecogene.org/geneInfo.php?eg_id=EG10476 EnsemblBacteria AAC75765 http://www.ensemblgenomes.org/id/AAC75765 EnsemblBacteria AAC75765 http://www.ensemblgenomes.org/id/AAC75765 EnsemblBacteria BAE76800 http://www.ensemblgenomes.org/id/BAE76800 EnsemblBacteria BAE76800 http://www.ensemblgenomes.org/id/BAE76800 EnsemblBacteria BAE76800 http://www.ensemblgenomes.org/id/BAE76800 EnsemblBacteria b2723 http://www.ensemblgenomes.org/id/b2723 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008137 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008137 GO_process GO:0042773 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042773 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GeneID 945327 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945327 HOGENOM HOG000278686 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278686&db=HOGENOM6 InParanoid P16429 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P16429 IntAct P16429 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P16429* InterPro IPR001750 http://www.ebi.ac.uk/interpro/entry/IPR001750 InterPro IPR003918 http://www.ebi.ac.uk/interpro/entry/IPR003918 KEGG_Gene ecj:JW2693 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2693 KEGG_Gene eco:b2723 http://www.genome.jp/dbget-bin/www_bget?eco:b2723 KEGG_Orthology KO:K15828 http://www.genome.jp/dbget-bin/www_bget?KO:K15828 MINT MINT-1240211 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1240211 OMA HSLFKTT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HSLFKTT PRINTS PR01437 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01437 PSORT swissprot:HYCC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HYCC_ECOLI PSORT-B swissprot:HYCC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HYCC_ECOLI PSORT2 swissprot:HYCC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HYCC_ECOLI Pfam PF00361 http://pfam.xfam.org/family/PF00361 Phobius swissprot:HYCC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HYCC_ECOLI PhylomeDB P16429 http://phylomedb.org/?seqid=P16429 ProteinModelPortal P16429 http://www.proteinmodelportal.org/query/uniprot/P16429 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2187144 http://www.ncbi.nlm.nih.gov/pubmed/2187144 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417203 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417203 RefSeq WP_001274396 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001274396 STRING 511145.b2723 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2723&targetmode=cogs STRING COG0651 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0651&targetmode=cogs TCDB 3.D.1.9 http://www.tcdb.org/search/result.php?tc=3.D.1.9 UniProtKB HYCC_ECOLI http://www.uniprot.org/uniprot/HYCC_ECOLI UniProtKB-AC P16429 http://www.uniprot.org/uniprot/P16429 charge swissprot:HYCC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HYCC_ECOLI eggNOG COG0651 http://eggnogapi.embl.de/nog_data/html/tree/COG0651 eggNOG ENOG4107R30 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107R30 epestfind swissprot:HYCC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HYCC_ECOLI garnier swissprot:HYCC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HYCC_ECOLI helixturnhelix swissprot:HYCC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HYCC_ECOLI hmoment swissprot:HYCC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HYCC_ECOLI iep swissprot:HYCC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HYCC_ECOLI inforesidue swissprot:HYCC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HYCC_ECOLI octanol swissprot:HYCC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HYCC_ECOLI pepcoil swissprot:HYCC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HYCC_ECOLI pepdigest swissprot:HYCC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HYCC_ECOLI pepinfo swissprot:HYCC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HYCC_ECOLI pepnet swissprot:HYCC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HYCC_ECOLI pepstats swissprot:HYCC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HYCC_ECOLI pepwheel swissprot:HYCC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HYCC_ECOLI pepwindow swissprot:HYCC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HYCC_ECOLI sigcleave swissprot:HYCC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HYCC_ECOLI ## Database ID URL or Descriptions # AltName RL36_ECOLI Ribosomal protein B # BioGrid 4263387 33 # EcoGene EG11232 rpmJ # GO_component GO:0022625 cytosolic large ribosomal subunit; IDA:EcoCyc. # GO_function GO:0003735 structural constituent of ribosome; IEA:InterPro. # GO_process GO:0006412 translation; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_process GO:0006412 translation # HAMAP MF_00251 Ribosomal_L36 # IntAct P0A7Q6 2 # InterPro IPR000473 Ribosomal_L36 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=4364.2; Method=MALDI; Range=1-38; Evidence={ECO:0000269|PubMed 10094780}; # Organism RL36_ECOLI Escherichia coli (strain K12) # PANTHER PTHR18804 PTHR18804 # PATRIC 32122030 VBIEscCol129921_3392 # PDB 2J28 EM; 8.00 A; 4=1-38 # PDB 2RDO EM; 9.10 A; 4=1-38 # PDB 3BBX EM; 10.00 A; 4=1-38 # PDB 3J5L EM; 6.60 A; 4=1-38 # PDB 3J7Z EM; 3.90 A; 4=1-38 # PDB 3J8G EM; 5.00 A; 8=1-38 # PDB 3J9Y EM; 3.90 A; 4=1-38 # PDB 3J9Z EM; 3.60 A; L5=1-38 # PDB 3JA1 EM; 3.60 A; L7=1-38 # PDB 3JBU EM; 3.64 A; 8=1-38 # PDB 3JBV EM; 3.32 A; 8=1-38 # PDB 3JCD EM; 3.70 A; 4=1-38 # PDB 3JCE EM; 3.20 A; 4=1-38 # PDB 3JCJ EM; 3.70 A; d=1-38 # PDB 3JCN EM; 4.60 A; 4=1-38 # PDB 4CSU EM; 5.50 A; 8=1-38 # PDB 4U1U X-ray; 2.95 A; B4/D4=1-38 # PDB 4U1V X-ray; 3.00 A; B4/D4=1-38 # PDB 4U20 X-ray; 2.90 A; B4/D4=1-38 # PDB 4U24 X-ray; 2.90 A; B4/D4=1-38 # PDB 4U25 X-ray; 2.90 A; B4/D4=1-38 # PDB 4U26 X-ray; 2.80 A; B4/D4=1-38 # PDB 4U27 X-ray; 2.80 A; B4/D4=1-38 # PDB 4UY8 EM; 3.80 A; 4=1-38 # PDB 4V47 EM; 12.30 A; A4=1-38 # PDB 4V48 EM; 11.50 A; A4=1-38 # PDB 4V4H X-ray; 3.46 A; B4/D4=1-38 # PDB 4V4Q X-ray; 3.46 A; B4/D4=1-38 # PDB 4V50 X-ray; 3.22 A; B4/D4=1-38 # PDB 4V52 X-ray; 3.21 A; B4/D4=1-38 # PDB 4V53 X-ray; 3.54 A; B4/D4=1-38 # PDB 4V54 X-ray; 3.30 A; B4/D4=1-38 # PDB 4V55 X-ray; 4.00 A; B4/D4=1-38 # PDB 4V56 X-ray; 3.93 A; B4/D4=1-38 # PDB 4V57 X-ray; 3.50 A; B4/D4=1-38 # PDB 4V5B X-ray; 3.74 A; A4/C4=1-38 # PDB 4V5H EM; 5.80 A; B8=1-38 # PDB 4V5Y X-ray; 4.45 A; B4/D4=1-38 # PDB 4V64 X-ray; 3.50 A; B4/D4=1-38 # PDB 4V65 EM; 9.00 A; BX=1-38 # PDB 4V66 EM; 9.00 A; BX=1-38 # PDB 4V69 EM; 6.70 A; B4=1-38 # PDB 4V6C X-ray; 3.19 A; B4/D4=1-38 # PDB 4V6D X-ray; 3.81 A; B4/D4=1-38 # PDB 4V6E X-ray; 3.71 A; B4/D4=1-38 # PDB 4V6K EM; 8.25 A; Ag=1-38 # PDB 4V6L EM; 13.20 A; Bg=1-38 # PDB 4V6M EM; 7.10 A; B4=1-38 # PDB 4V6N EM; 12.10 A; A7=1-38 # PDB 4V6O EM; 14.70 A; B7=1-38 # PDB 4V6P EM; 13.50 A; B7=1-38 # PDB 4V6Q EM; 11.50 A; B7=1-38 # PDB 4V6R EM; 11.50 A; B7=1-38 # PDB 4V6S EM; 13.10 A; A7=1-38 # PDB 4V6T EM; 8.30 A; B4=1-38 # PDB 4V6V EM; 9.80 A; B9=1-38 # PDB 4V6Y EM; 12.00 A; B4=1-38 # PDB 4V6Z EM; 12.00 A; B4=1-38 # PDB 4V70 EM; 17.00 A; B4=1-38 # PDB 4V71 EM; 20.00 A; B4=1-38 # PDB 4V72 EM; 13.00 A; B4=1-38 # PDB 4V73 EM; 15.00 A; B4=1-38 # PDB 4V74 EM; 17.00 A; B4=1-38 # PDB 4V75 EM; 12.00 A; B4=1-38 # PDB 4V76 EM; 17.00 A; B4=1-38 # PDB 4V77 EM; 17.00 A; B4=1-38 # PDB 4V78 EM; 20.00 A; B4=1-38 # PDB 4V79 EM; 15.00 A; B4=1-38 # PDB 4V7A EM; 9.00 A; B4=1-38 # PDB 4V7B EM; 6.80 A; B4=1-38 # PDB 4V7C EM; 7.60 A; B7=1-38 # PDB 4V7D EM; 7.60 A; A8=1-38 # PDB 4V7I EM; 9.60 A; A4=1-38 # PDB 4V7S X-ray; 3.25 A; B4/D4=1-38 # PDB 4V7T X-ray; 3.19 A; B4/D4=1-38 # PDB 4V7U X-ray; 3.10 A; B4/D4=1-38 # PDB 4V7V X-ray; 3.29 A; B4/D4=1-38 # PDB 4V85 X-ray; 3.20 A; 8=1-38 # PDB 4V89 X-ray; 3.70 A; B8=1-38 # PDB 4V9C X-ray; 3.30 A; B4/D4=1-38 # PDB 4V9D X-ray; 3.00 A; C4/D4=1-38 # PDB 4V9O X-ray; 2.90 A; A4/C4/E4/G4=1-38 # PDB 4V9P X-ray; 2.90 A; A4/C4/E4/G4=1-38 # PDB 4WF1 X-ray; 3.09 A; B4/D4=1-38 # PDB 4WOI X-ray; 3.00 A; B4/C4=1-38 # PDB 4WWW X-ray; 3.10 A; R4/Y4=1-38 # PDB 4YBB X-ray; 2.10 A; C5/D5=1-38 # PDB 5ADY EM; 4.50 A; 4=1-38 # PDB 5AFI EM; 2.90 A; 4=1-38 # PDB 5AKA EM; 5.70 A; 4=1-38 # PDB 5GAD EM; 3.70 A; f=1-38 # PDB 5GAE EM; 3.33 A; f=1-38 # PDB 5GAF EM; 4.30 A; f=1-38 # PDB 5GAG EM; 3.80 A; f=1-38 # PDB 5GAH EM; 3.80 A; f=1-38 # PDB 5IQR EM; 3.00 A; f=1-38 # PDB 5IT8 X-ray; 3.12 A; C5/D5=1-38 # PDB 5J5B X-ray; 2.80 A; C5/D5=1-38 # PDB 5J7L X-ray; 3.00 A; C5/D5=1-38 # PDB 5J88 X-ray; 3.32 A; C5/D5=1-38 # PDB 5J8A X-ray; 3.10 A; C5/D5=1-38 # PDB 5J91 X-ray; 2.96 A; C5/D5=1-38 # PDB 5JC9 X-ray; 3.03 A; C5/D5=1-38 # PDB 5JTE EM; 3.60 A; B4=1-38 # PDB 5JU8 EM; 3.60 A; B4=1-38 # PDB 5KCR EM; 3.60 A; 19=1-38 # PDB 5KCS EM; 3.90 A; 19=1-38 # PDB 5KPS EM; 3.90 A; 6=1-38 # PDB 5KPV EM; 4.10 A; 5=1-38 # PDB 5KPW EM; 3.90 A; 5=1-38 # PDB 5KPX EM; 3.90 A; 5=1-38 # PDB 5L3P EM; 3.70 A; 9=1-38 # PIR S14057 R5EC36 # PROSITE PS00828 RIBOSOMAL_L36 # Pfam PF00444 Ribosomal_L36 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RL36_ECOLI 50S ribosomal protein L36 # RefSeq NP_417758 NC_000913.3 # RefSeq WP_000868187 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein L36P family. {ECO 0000305}. # SUPFAM SSF57840 SSF57840 # TIGRFAMs TIGR01022 rpmJ_bact # eggNOG COG0257 LUCA BLAST swissprot:RL36_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RL36_ECOLI BioCyc ECOL316407:JW3261-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3261-MONOMER BioCyc EcoCyc:EG11232-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11232-MONOMER BioCyc MetaCyc:EG11232-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11232-MONOMER COG COG0257 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0257 DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1016/S0092-8674(03)00427-6 http://dx.doi.org/10.1016/S0092-8674(03)00427-6 DOI 10.1016/j.celrep.2014.09.011 http://dx.doi.org/10.1016/j.celrep.2014.09.011 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pbio.1001866 http://dx.doi.org/10.1371/journal.pbio.1001866 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M12432 http://www.ebi.ac.uk/ena/data/view/M12432 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X01563 http://www.ebi.ac.uk/ena/data/view/X01563 EchoBASE EB1214 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1214 EcoGene EG11232 http://www.ecogene.org/geneInfo.php?eg_id=EG11232 EnsemblBacteria AAC76324 http://www.ensemblgenomes.org/id/AAC76324 EnsemblBacteria AAC76324 http://www.ensemblgenomes.org/id/AAC76324 EnsemblBacteria BAE77992 http://www.ensemblgenomes.org/id/BAE77992 EnsemblBacteria BAE77992 http://www.ensemblgenomes.org/id/BAE77992 EnsemblBacteria BAE77992 http://www.ensemblgenomes.org/id/BAE77992 EnsemblBacteria b3299 http://www.ensemblgenomes.org/id/b3299 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0022625 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022625 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GeneID 23844461 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23844461 GeneID 947805 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947805 HAMAP MF_00251 http://hamap.expasy.org/unirule/MF_00251 HOGENOM HOG000111584 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000111584&db=HOGENOM6 InParanoid P0A7Q6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7Q6 IntAct P0A7Q6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7Q6* InterPro IPR000473 http://www.ebi.ac.uk/interpro/entry/IPR000473 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW3261 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3261 KEGG_Gene eco:b3299 http://www.genome.jp/dbget-bin/www_bget?eco:b3299 KEGG_Orthology KO:K02919 http://www.genome.jp/dbget-bin/www_bget?KO:K02919 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 PANTHER PTHR18804 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18804 PDB 2J28 http://www.ebi.ac.uk/pdbe-srv/view/entry/2J28 PDB 2RDO http://www.ebi.ac.uk/pdbe-srv/view/entry/2RDO PDB 3BBX http://www.ebi.ac.uk/pdbe-srv/view/entry/3BBX PDB 3J5L http://www.ebi.ac.uk/pdbe-srv/view/entry/3J5L PDB 3J7Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J7Z PDB 3J8G http://www.ebi.ac.uk/pdbe-srv/view/entry/3J8G PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 4CSU http://www.ebi.ac.uk/pdbe-srv/view/entry/4CSU PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4UY8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4UY8 PDB 4V47 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V47 PDB 4V48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V48 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5ADY http://www.ebi.ac.uk/pdbe-srv/view/entry/5ADY PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5AKA http://www.ebi.ac.uk/pdbe-srv/view/entry/5AKA PDB 5GAD http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAD PDB 5GAE http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAE PDB 5GAF http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAF PDB 5GAG http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAG PDB 5GAH http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAH PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 2J28 http://www.ebi.ac.uk/pdbsum/2J28 PDBsum 2RDO http://www.ebi.ac.uk/pdbsum/2RDO PDBsum 3BBX http://www.ebi.ac.uk/pdbsum/3BBX PDBsum 3J5L http://www.ebi.ac.uk/pdbsum/3J5L PDBsum 3J7Z http://www.ebi.ac.uk/pdbsum/3J7Z PDBsum 3J8G http://www.ebi.ac.uk/pdbsum/3J8G PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 4CSU http://www.ebi.ac.uk/pdbsum/4CSU PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4UY8 http://www.ebi.ac.uk/pdbsum/4UY8 PDBsum 4V47 http://www.ebi.ac.uk/pdbsum/4V47 PDBsum 4V48 http://www.ebi.ac.uk/pdbsum/4V48 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5ADY http://www.ebi.ac.uk/pdbsum/5ADY PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5AKA http://www.ebi.ac.uk/pdbsum/5AKA PDBsum 5GAD http://www.ebi.ac.uk/pdbsum/5GAD PDBsum 5GAE http://www.ebi.ac.uk/pdbsum/5GAE PDBsum 5GAF http://www.ebi.ac.uk/pdbsum/5GAF PDBsum 5GAG http://www.ebi.ac.uk/pdbsum/5GAG PDBsum 5GAH http://www.ebi.ac.uk/pdbsum/5GAH PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PROSITE PS00828 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00828 PSORT swissprot:RL36_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RL36_ECOLI PSORT-B swissprot:RL36_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RL36_ECOLI PSORT2 swissprot:RL36_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RL36_ECOLI Pfam PF00444 http://pfam.xfam.org/family/PF00444 Phobius swissprot:RL36_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RL36_ECOLI PhylomeDB P0A7Q6 http://phylomedb.org/?seqid=P0A7Q6 ProteinModelPortal P0A7Q6 http://www.proteinmodelportal.org/query/uniprot/P0A7Q6 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 12809609 http://www.ncbi.nlm.nih.gov/pubmed/12809609 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 24844575 http://www.ncbi.nlm.nih.gov/pubmed/24844575 PubMed 25310980 http://www.ncbi.nlm.nih.gov/pubmed/25310980 PubMed 3298224 http://www.ncbi.nlm.nih.gov/pubmed/3298224 PubMed 6154696 http://www.ncbi.nlm.nih.gov/pubmed/6154696 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417758 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417758 RefSeq WP_000868187 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000868187 SMR P0A7Q6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7Q6 STRING 511145.b3299 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3299&targetmode=cogs STRING COG0257 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0257&targetmode=cogs SUPFAM SSF57840 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF57840 TIGRFAMs TIGR01022 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01022 UniProtKB RL36_ECOLI http://www.uniprot.org/uniprot/RL36_ECOLI UniProtKB-AC P0A7Q6 http://www.uniprot.org/uniprot/P0A7Q6 charge swissprot:RL36_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RL36_ECOLI eggNOG COG0257 http://eggnogapi.embl.de/nog_data/html/tree/COG0257 epestfind swissprot:RL36_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RL36_ECOLI garnier swissprot:RL36_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RL36_ECOLI helixturnhelix swissprot:RL36_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RL36_ECOLI hmoment swissprot:RL36_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RL36_ECOLI iep swissprot:RL36_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RL36_ECOLI inforesidue swissprot:RL36_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RL36_ECOLI octanol swissprot:RL36_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RL36_ECOLI pepcoil swissprot:RL36_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RL36_ECOLI pepdigest swissprot:RL36_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RL36_ECOLI pepinfo swissprot:RL36_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RL36_ECOLI pepnet swissprot:RL36_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RL36_ECOLI pepstats swissprot:RL36_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RL36_ECOLI pepwheel swissprot:RL36_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RL36_ECOLI pepwindow swissprot:RL36_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RL36_ECOLI sigcleave swissprot:RL36_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RL36_ECOLI ## Database ID URL or Descriptions # AltName TFAS_ECOLI Putative tail fiber assembly protein homolog from prophage CPS-53 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG14134 tfaS # InterPro IPR003458 Phage_T4_Gp38_tail_assem # Organism TFAS_ECOLI Escherichia coli (strain K12) # PIR F65008 F65008 # Pfam PF02413 Caudo_TAP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Putative protein TfaS {ECO 0000305} # RefSeq WP_014639037 NZ_LN832404.1 # SIMILARITY Belongs to the tfa family. {ECO 0000305}. BLAST swissprot:TFAS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TFAS_ECOLI DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14134 http://www.ecogene.org/geneInfo.php?eg_id=EG14134 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv InterPro IPR003458 http://www.ebi.ac.uk/interpro/entry/IPR003458 PSORT swissprot:TFAS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TFAS_ECOLI PSORT-B swissprot:TFAS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TFAS_ECOLI PSORT2 swissprot:TFAS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TFAS_ECOLI Pfam PF02413 http://pfam.xfam.org/family/PF02413 Phobius swissprot:TFAS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TFAS_ECOLI ProteinModelPortal P77326 http://www.proteinmodelportal.org/query/uniprot/P77326 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_014639037 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_014639037 SMR P77326 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77326 UniProtKB TFAS_ECOLI http://www.uniprot.org/uniprot/TFAS_ECOLI UniProtKB-AC P77326 http://www.uniprot.org/uniprot/P77326 charge swissprot:TFAS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TFAS_ECOLI epestfind swissprot:TFAS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TFAS_ECOLI garnier swissprot:TFAS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TFAS_ECOLI helixturnhelix swissprot:TFAS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TFAS_ECOLI hmoment swissprot:TFAS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TFAS_ECOLI iep swissprot:TFAS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TFAS_ECOLI inforesidue swissprot:TFAS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TFAS_ECOLI octanol swissprot:TFAS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TFAS_ECOLI pepcoil swissprot:TFAS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TFAS_ECOLI pepdigest swissprot:TFAS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TFAS_ECOLI pepinfo swissprot:TFAS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TFAS_ECOLI pepnet swissprot:TFAS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TFAS_ECOLI pepstats swissprot:TFAS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TFAS_ECOLI pepwheel swissprot:TFAS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TFAS_ECOLI pepwindow swissprot:TFAS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TFAS_ECOLI sigcleave swissprot:TFAS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TFAS_ECOLI ## Database ID URL or Descriptions # BRENDA 1.7.1.15 2026 # BioGrid 4262476 13 # CATALYTIC ACTIVITY NIRD_ECOLI Ammonia + 3 NAD(+) + 2 H(2)O = nitrite + 3 NADH. # CDD cd03529 Rieske_NirD # EcoGene EG10655 nirD # FUNCTION NIRD_ECOLI Required for activity of the reductase. {ECO 0000269|PubMed 1435259}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_component GO:0009344 nitrite reductase complex [NAD(P)H]; IDA:EcoCyc. # GO_function GO:0008942 nitrite reductase [NAD(P)H] activity; IDA:EcoCyc. # GO_function GO:0051537 2 iron, 2 sulfur cluster binding; IEA:InterPro. # GO_process GO:0009061 anaerobic respiration; IEP:EcoCyc. # GO_process GO:0042128 nitrate assimilation; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0071941 nitrogen cycle metabolic process # Gene3D 2.102.10.10 -; 1. # InterPro IPR012748 Nitri_red_NirD # InterPro IPR017881 Nitrite_Rdtase_lsu_NirD_bac # InterPro IPR017941 Rieske_2Fe-2S # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00910 Nitrogen metabolism # Organism NIRD_ECOLI Escherichia coli (strain K12) # PATRIC 32122166 VBIEscCol129921_3460 # PDB 2JO6 NMR; -; A=1-108 # PIR A65131 A65131 # PROSITE PS51300 NIRD # Pfam PF13806 Rieske_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NIRD_ECOLI Nitrite reductase (NADH) small subunit # RefSeq NP_417825 NC_000913.3 # RefSeq WP_000084764 NZ_LN832404.1 # SIMILARITY To B.subtilis NasE. {ECO 0000305}. # SUBCELLULAR LOCATION NIRD_ECOLI Cytoplasm. # SUBUNIT NIRD_ECOLI Associates with NirB. # SUPFAM SSF50022 SSF50022 # TIGRFAMs TIGR02378 nirD_assim_sml # eggNOG COG2146 LUCA # eggNOG ENOG4105WZK Bacteria BLAST swissprot:NIRD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NIRD_ECOLI BioCyc ECOL316407:JW3329-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3329-MONOMER BioCyc EcoCyc:NIRD-MONOMER http://biocyc.org/getid?id=EcoCyc:NIRD-MONOMER BioCyc MetaCyc:NIRD-MONOMER http://biocyc.org/getid?id=MetaCyc:NIRD-MONOMER COG COG2146 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2146 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/17.10.3865 http://dx.doi.org/10.1093/nar/17.10.3865 DOI 10.1111/j.1365-2958.1992.tb01460.x http://dx.doi.org/10.1111/j.1365-2958.1992.tb01460.x DOI 10.1111/j.1432-1033.1990.tb19125.x http://dx.doi.org/10.1111/j.1432-1033.1990.tb19125.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.7.1.15 http://www.genome.jp/dbget-bin/www_bget?EC:1.7.1.15 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X14202 http://www.ebi.ac.uk/ena/data/view/X14202 ENZYME 1.7.1.15 http://enzyme.expasy.org/EC/1.7.1.15 EchoBASE EB0649 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0649 EcoGene EG10655 http://www.ecogene.org/geneInfo.php?eg_id=EG10655 EnsemblBacteria AAC76391 http://www.ensemblgenomes.org/id/AAC76391 EnsemblBacteria AAC76391 http://www.ensemblgenomes.org/id/AAC76391 EnsemblBacteria BAE77924 http://www.ensemblgenomes.org/id/BAE77924 EnsemblBacteria BAE77924 http://www.ensemblgenomes.org/id/BAE77924 EnsemblBacteria BAE77924 http://www.ensemblgenomes.org/id/BAE77924 EnsemblBacteria b3366 http://www.ensemblgenomes.org/id/b3366 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0009344 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009344 GO_function GO:0008942 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008942 GO_function GO:0051537 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051537 GO_process GO:0009061 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009061 GO_process GO:0042128 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042128 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0071941 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071941 Gene3D 2.102.10.10 http://www.cathdb.info/version/latest/superfamily/2.102.10.10 GeneID 947881 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947881 HOGENOM HOG000128543 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000128543&db=HOGENOM6 InParanoid P0A9I8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9I8 IntEnz 1.7.1.15 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.7.1.15 InterPro IPR012748 http://www.ebi.ac.uk/interpro/entry/IPR012748 InterPro IPR017881 http://www.ebi.ac.uk/interpro/entry/IPR017881 InterPro IPR017941 http://www.ebi.ac.uk/interpro/entry/IPR017941 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3329 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3329 KEGG_Gene eco:b3366 http://www.genome.jp/dbget-bin/www_bget?eco:b3366 KEGG_Orthology KO:K00363 http://www.genome.jp/dbget-bin/www_bget?KO:K00363 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Reaction rn:R00787 http://www.genome.jp/dbget-bin/www_bget?rn:R00787 KEGG_Reaction rn:R00789 http://www.genome.jp/dbget-bin/www_bget?rn:R00789 OMA LRDGLCM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LRDGLCM PDB 2JO6 http://www.ebi.ac.uk/pdbe-srv/view/entry/2JO6 PDBsum 2JO6 http://www.ebi.ac.uk/pdbsum/2JO6 PROSITE PS51300 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51300 PSORT swissprot:NIRD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NIRD_ECOLI PSORT-B swissprot:NIRD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NIRD_ECOLI PSORT2 swissprot:NIRD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NIRD_ECOLI Pfam PF13806 http://pfam.xfam.org/family/PF13806 Phobius swissprot:NIRD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NIRD_ECOLI PhylomeDB P0A9I8 http://phylomedb.org/?seqid=P0A9I8 ProteinModelPortal P0A9I8 http://www.proteinmodelportal.org/query/uniprot/P0A9I8 PubMed 1435259 http://www.ncbi.nlm.nih.gov/pubmed/1435259 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2200672 http://www.ncbi.nlm.nih.gov/pubmed/2200672 PubMed 2543955 http://www.ncbi.nlm.nih.gov/pubmed/2543955 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417825 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417825 RefSeq WP_000084764 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000084764 SMR P0A9I8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9I8 STRING 511145.b3366 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3366&targetmode=cogs STRING COG2146 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2146&targetmode=cogs SUPFAM SSF50022 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50022 TIGRFAMs TIGR02378 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02378 UniProtKB NIRD_ECOLI http://www.uniprot.org/uniprot/NIRD_ECOLI UniProtKB-AC P0A9I8 http://www.uniprot.org/uniprot/P0A9I8 charge swissprot:NIRD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NIRD_ECOLI eggNOG COG2146 http://eggnogapi.embl.de/nog_data/html/tree/COG2146 eggNOG ENOG4105WZK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105WZK epestfind swissprot:NIRD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NIRD_ECOLI garnier swissprot:NIRD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NIRD_ECOLI helixturnhelix swissprot:NIRD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NIRD_ECOLI hmoment swissprot:NIRD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NIRD_ECOLI iep swissprot:NIRD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NIRD_ECOLI inforesidue swissprot:NIRD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NIRD_ECOLI octanol swissprot:NIRD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NIRD_ECOLI pepcoil swissprot:NIRD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NIRD_ECOLI pepdigest swissprot:NIRD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NIRD_ECOLI pepinfo swissprot:NIRD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NIRD_ECOLI pepnet swissprot:NIRD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NIRD_ECOLI pepstats swissprot:NIRD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NIRD_ECOLI pepwheel swissprot:NIRD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NIRD_ECOLI pepwindow swissprot:NIRD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NIRD_ECOLI sigcleave swissprot:NIRD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NIRD_ECOLI ## Database ID URL or Descriptions # AltName RZPR_ECOLI Putative Rz endopeptidase from lambdoid prophage Rac # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG13366 rzpR # FUNCTION RZPR_ECOLI Necessary for host cell lysis. It is believed to code for an endopeptidase that cleaves the amino-carboxyl cross-link between the diaminopimelic acid and D-alanine residues in the murein component of the bacterial cell wall (By similarity). {ECO 0000250}. # GO_function GO:0008233 peptidase activity; IEA:UniProtKB-KW. # GO_process GO:0019076 viral release from host cell; IEA:InterPro. # GO_process GO:0019835 cytolysis; IEA:UniProtKB-KW. # GO_process GO:0042742 defense response to bacterium; IEA:UniProtKB-KW. # GOslim_function GO:0008233 peptidase activity # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0040011 locomotion # GOslim_process GO:0044403 symbiosis, encompassing mutualism through parasitism # INTERACTION RZPR_ECOLI P0A8P6 xerC; NbExp=2; IntAct=EBI-9135212, EBI-1133806; # IntAct P77551 4 # InterPro IPR004929 i-spanin # Organism RZPR_ECOLI Escherichia coli (strain K12) # PATRIC 48662017 VBIEscCol107702_1372 # PIR E64886 E64886 # Pfam PF03245 Phage_lysis # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Putative endopeptidase RzpR {ECO 0000305} BLAST swissprot:RZPR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RZPR_ECOLI BioCyc ECOL316407:JW5212-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5212-MONOMER BioCyc EcoCyc:G6686-MONOMER http://biocyc.org/getid?id=EcoCyc:G6686-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.4.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.4.-.- http://enzyme.expasy.org/EC/3.4.-.- EchoBASE EB3149 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3149 EcoGene EG13366 http://www.ecogene.org/geneInfo.php?eg_id=EG13366 EnsemblBacteria BAA14959 http://www.ensemblgenomes.org/id/BAA14959 EnsemblBacteria BAA14959 http://www.ensemblgenomes.org/id/BAA14959 EnsemblBacteria BAA14959 http://www.ensemblgenomes.org/id/BAA14959 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GO_process GO:0019076 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019076 GO_process GO:0019835 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019835 GO_process GO:0042742 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042742 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0040011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011 GOslim_process GO:0044403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403 HOGENOM HOG000119352 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000119352&db=HOGENOM6 IntAct P77551 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77551* IntEnz 3.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4 InterPro IPR004929 http://www.ebi.ac.uk/interpro/entry/IPR004929 KEGG_Gene ecj:JW5212 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5212 OMA HIKAVCP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HIKAVCP PSORT swissprot:RZPR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RZPR_ECOLI PSORT-B swissprot:RZPR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RZPR_ECOLI PSORT2 swissprot:RZPR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RZPR_ECOLI Pfam PF03245 http://pfam.xfam.org/family/PF03245 Phobius swissprot:RZPR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RZPR_ECOLI PhylomeDB P77551 http://phylomedb.org/?seqid=P77551 ProteinModelPortal P77551 http://www.proteinmodelportal.org/query/uniprot/P77551 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SMR P77551 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77551 STRING 316407.85674926 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85674926&targetmode=cogs UniProtKB RZPR_ECOLI http://www.uniprot.org/uniprot/RZPR_ECOLI UniProtKB-AC P77551 http://www.uniprot.org/uniprot/P77551 charge swissprot:RZPR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RZPR_ECOLI epestfind swissprot:RZPR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RZPR_ECOLI garnier swissprot:RZPR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RZPR_ECOLI helixturnhelix swissprot:RZPR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RZPR_ECOLI hmoment swissprot:RZPR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RZPR_ECOLI iep swissprot:RZPR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RZPR_ECOLI inforesidue swissprot:RZPR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RZPR_ECOLI octanol swissprot:RZPR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RZPR_ECOLI pepcoil swissprot:RZPR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RZPR_ECOLI pepdigest swissprot:RZPR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RZPR_ECOLI pepinfo swissprot:RZPR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RZPR_ECOLI pepnet swissprot:RZPR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RZPR_ECOLI pepstats swissprot:RZPR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RZPR_ECOLI pepwheel swissprot:RZPR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RZPR_ECOLI pepwindow swissprot:RZPR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RZPR_ECOLI sigcleave swissprot:RZPR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RZPR_ECOLI ## Database ID URL or Descriptions # BioGrid 4260455 240 # BioGrid 4260456 22 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG12020 mdtQ # FUNCTION MDTQ_ECOLI Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride. {ECO 0000269|PubMed 11257026}. # GO_component GO:0009279 cell outer membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005215 transporter activity; IEA:InterPro. # GO_function GO:0008289 lipid binding; IEA:InterPro. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008289 lipid binding # GOslim_process GO:0008150 biological_process # InterPro IPR003423 OMP_efflux # InterPro IPR010131 RND_efflux_OM_lipoprot_NodT # Organism MDTQ_ECOLI Escherichia coli (strain K12) # PATRIC 48663636 VBIEscCol107702_2163 # PIR A64982 A64982 # PIR B64982 B64982 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF02321 OEP; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MDTQ_ECOLI Putative multidrug resistance outer membrane protein MdtQ # SEQUENCE CAUTION MDTQ_ECOLI Sequence=AAA60501.1; Type=Frameshift; Positions=56; Note=Produces two separate ORFs.; Evidence={ECO 0000305}; Sequence=AAA60502.1; Type=Frameshift; Positions=56; Note=Produces two separate ORFs.; Evidence={ECO 0000305}; Sequence=BAE76615.1; Type=Frameshift; Positions=56; Note=Produces two separate ORFs.; Evidence={ECO 0000305}; Sequence=BAE76616.1; Type=Frameshift; Positions=56; Note=Produces two separate ORFs.; Evidence={ECO 0000305}; Sequence=U00096; Type=Frameshift; Positions=56; Note=Produces two separate ORFs.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. {ECO 0000305}. # SUBCELLULAR LOCATION MDTQ_ECOLI Cell outer membrane {ECO 0000305}; Lipid- anchor {ECO 0000255|PROSITE-ProRule PRU00303}. # TCDB 1.B.17.3.10 the outer membrane factor (omf) family # TIGRFAMs TIGR01845 outer_NodT # eggNOG COG1538 LUCA # eggNOG ENOG4105ETP Bacteria BLAST swissprot:MDTQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MDTQ_ECOLI BioCyc ECOL316407:JW5358-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5358-MONOMER BioCyc ECOL316407:JW5838-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5838-MONOMER BioCyc EcoCyc:EG12020-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12020-MONOMER BioCyc EcoCyc:EG12021-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12021-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AAC.45.4.1126-1136.2001 http://dx.doi.org/10.1128/AAC.45.4.1126-1136.2001 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1956 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1956 EcoGene EG12020 http://www.ecogene.org/geneInfo.php?eg_id=EG12020 EnsemblBacteria BAE76615 http://www.ensemblgenomes.org/id/BAE76615 EnsemblBacteria BAE76615 http://www.ensemblgenomes.org/id/BAE76615 EnsemblBacteria BAE76615 http://www.ensemblgenomes.org/id/BAE76615 EnsemblBacteria BAE76616 http://www.ensemblgenomes.org/id/BAE76616 EnsemblBacteria BAE76616 http://www.ensemblgenomes.org/id/BAE76616 EnsemblBacteria BAE76616 http://www.ensemblgenomes.org/id/BAE76616 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_function GO:0008289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 HOGENOM HOG000122243 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122243&db=HOGENOM6 InParanoid P33369 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33369 IntAct P33369 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33369* InterPro IPR003423 http://www.ebi.ac.uk/interpro/entry/IPR003423 InterPro IPR010131 http://www.ebi.ac.uk/interpro/entry/IPR010131 KEGG_Gene ecj:JW5358 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5358 KEGG_Gene ecj:JW5838 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5838 OMA RTYIEMS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RTYIEMS PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:MDTQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MDTQ_ECOLI PSORT-B swissprot:MDTQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MDTQ_ECOLI PSORT2 swissprot:MDTQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MDTQ_ECOLI Pfam PF02321 http://pfam.xfam.org/family/PF02321 Phobius swissprot:MDTQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MDTQ_ECOLI PhylomeDB P33369 http://phylomedb.org/?seqid=P33369 ProteinModelPortal P33369 http://www.proteinmodelportal.org/query/uniprot/P33369 PubMed 11257026 http://www.ncbi.nlm.nih.gov/pubmed/11257026 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 STRING 316407.85675252 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85675252&targetmode=cogs TCDB 1.B.17.3.10 http://www.tcdb.org/search/result.php?tc=1.B.17.3.10 TIGRFAMs TIGR01845 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01845 UniProtKB MDTQ_ECOLI http://www.uniprot.org/uniprot/MDTQ_ECOLI UniProtKB-AC P33369 http://www.uniprot.org/uniprot/P33369 charge swissprot:MDTQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MDTQ_ECOLI eggNOG COG1538 http://eggnogapi.embl.de/nog_data/html/tree/COG1538 eggNOG ENOG4105ETP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ETP epestfind swissprot:MDTQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MDTQ_ECOLI garnier swissprot:MDTQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MDTQ_ECOLI helixturnhelix swissprot:MDTQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MDTQ_ECOLI hmoment swissprot:MDTQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MDTQ_ECOLI iep swissprot:MDTQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MDTQ_ECOLI inforesidue swissprot:MDTQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MDTQ_ECOLI octanol swissprot:MDTQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MDTQ_ECOLI pepcoil swissprot:MDTQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MDTQ_ECOLI pepdigest swissprot:MDTQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MDTQ_ECOLI pepinfo swissprot:MDTQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MDTQ_ECOLI pepnet swissprot:MDTQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MDTQ_ECOLI pepstats swissprot:MDTQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MDTQ_ECOLI pepwheel swissprot:MDTQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MDTQ_ECOLI pepwindow swissprot:MDTQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MDTQ_ECOLI sigcleave swissprot:MDTQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MDTQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4263083 5 # CDD cd00383 trans_reg_C # EcoGene EG11615 basR # FUNCTION BASR_ECOLI Member of the two-component regulatory system BasS/BasR. BasR induces the transcription of the ugd, ais, arnBCADTEF and eptA-basRS loci, all involved in resistance to polymyxin (By similarity). {ECO 0000250}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0000156 phosphorelay response regulator activity; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0000160 phosphorelay signal transduction system; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IMP:EcoCyc. # GO_process GO:0010041 response to iron(III) ion; IMP:EcoCyc. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004871 signal transducer activity # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # INDUCTION The eptA-basRS operon is positively autoregulated by BasR under high iron or aluminum concentration conditions. {ECO 0000250}. # IntAct P30843 5 # InterPro IPR001789 Sig_transdc_resp-reg_receiver # InterPro IPR001867 OmpR/PhoB-type_DNA-bd # InterPro IPR011006 CheY-like_superfamily # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR016032 Sig_transdc_resp-reg_C-effctor # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02022 M00451 BasS-BasR (antimicrobial peptide resistance) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # MISCELLANEOUS BASR_ECOLI The activity of the BasR protein is in some natural isolates, but not in strain K12, controlled at a post- transcriptional level by the PmrD protein under low Mg(2+) concentration conditions. # Organism BASR_ECOLI Escherichia coli (strain K12) # PATRIC 32123791 VBIEscCol129921_4244 # PIR H65220 H65220 # PROSITE PS50110 RESPONSE_REGULATORY # PROSITE PS51755 OMPR_PHOB # PTM BASR_ECOLI Phosphorylated by BasS. {ECO 0000269|PubMed 15522865}. # Pfam PF00072 Response_reg # Pfam PF00486 Trans_reg_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BASR_ECOLI Transcriptional regulatory protein BasR # RefSeq NP_418537 NC_000913.3 # RefSeq WP_000697926 NZ_LN832404.1 # SIMILARITY Contains 1 OmpR/PhoB-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU01091}. # SIMILARITY Contains 1 response regulatory domain. {ECO:0000255|PROSITE-ProRule PRU00169}. # SMART SM00448 REC # SMART SM00862 Trans_reg_C # SUBCELLULAR LOCATION BASR_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Homodimer. {ECO 0000250}. # SUPFAM SSF46894 SSF46894 # SUPFAM SSF52172 SSF52172 # eggNOG ENOG4105XJC Bacteria # eggNOG ENOG4111FPD LUCA BLAST swissprot:BASR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BASR_ECOLI BioCyc ECOL316407:JW4074-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4074-MONOMER BioCyc EcoCyc:BASR-MONOMER http://biocyc.org/getid?id=EcoCyc:BASR-MONOMER COG COG0745 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0745 DIP DIP-9201N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9201N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0406038101 http://dx.doi.org/10.1073/pnas.0406038101 DOI 10.1074/jbc.M410104200 http://dx.doi.org/10.1074/jbc.M410104200 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL AY725270 http://www.ebi.ac.uk/ena/data/view/AY725270 EMBL AY725271 http://www.ebi.ac.uk/ena/data/view/AY725271 EMBL AY725272 http://www.ebi.ac.uk/ena/data/view/AY725272 EMBL AY725273 http://www.ebi.ac.uk/ena/data/view/AY725273 EMBL AY725274 http://www.ebi.ac.uk/ena/data/view/AY725274 EMBL AY725275 http://www.ebi.ac.uk/ena/data/view/AY725275 EMBL AY725276 http://www.ebi.ac.uk/ena/data/view/AY725276 EMBL AY725277 http://www.ebi.ac.uk/ena/data/view/AY725277 EMBL AY725278 http://www.ebi.ac.uk/ena/data/view/AY725278 EMBL AY725279 http://www.ebi.ac.uk/ena/data/view/AY725279 EMBL AY725280 http://www.ebi.ac.uk/ena/data/view/AY725280 EMBL AY725281 http://www.ebi.ac.uk/ena/data/view/AY725281 EMBL AY725282 http://www.ebi.ac.uk/ena/data/view/AY725282 EMBL AY725283 http://www.ebi.ac.uk/ena/data/view/AY725283 EMBL AY725284 http://www.ebi.ac.uk/ena/data/view/AY725284 EMBL AY725285 http://www.ebi.ac.uk/ena/data/view/AY725285 EMBL AY725286 http://www.ebi.ac.uk/ena/data/view/AY725286 EMBL AY725287 http://www.ebi.ac.uk/ena/data/view/AY725287 EMBL AY725288 http://www.ebi.ac.uk/ena/data/view/AY725288 EMBL AY725289 http://www.ebi.ac.uk/ena/data/view/AY725289 EMBL AY725290 http://www.ebi.ac.uk/ena/data/view/AY725290 EMBL AY725291 http://www.ebi.ac.uk/ena/data/view/AY725291 EMBL AY725292 http://www.ebi.ac.uk/ena/data/view/AY725292 EMBL AY725293 http://www.ebi.ac.uk/ena/data/view/AY725293 EMBL AY725294 http://www.ebi.ac.uk/ena/data/view/AY725294 EMBL AY725295 http://www.ebi.ac.uk/ena/data/view/AY725295 EMBL AY725296 http://www.ebi.ac.uk/ena/data/view/AY725296 EMBL AY725297 http://www.ebi.ac.uk/ena/data/view/AY725297 EMBL AY725298 http://www.ebi.ac.uk/ena/data/view/AY725298 EMBL AY725299 http://www.ebi.ac.uk/ena/data/view/AY725299 EMBL AY725300 http://www.ebi.ac.uk/ena/data/view/AY725300 EMBL AY725301 http://www.ebi.ac.uk/ena/data/view/AY725301 EMBL AY725302 http://www.ebi.ac.uk/ena/data/view/AY725302 EMBL AY725303 http://www.ebi.ac.uk/ena/data/view/AY725303 EMBL AY725304 http://www.ebi.ac.uk/ena/data/view/AY725304 EMBL AY725305 http://www.ebi.ac.uk/ena/data/view/AY725305 EMBL AY725306 http://www.ebi.ac.uk/ena/data/view/AY725306 EMBL AY725307 http://www.ebi.ac.uk/ena/data/view/AY725307 EMBL AY725308 http://www.ebi.ac.uk/ena/data/view/AY725308 EMBL AY725309 http://www.ebi.ac.uk/ena/data/view/AY725309 EMBL AY725310 http://www.ebi.ac.uk/ena/data/view/AY725310 EMBL AY725311 http://www.ebi.ac.uk/ena/data/view/AY725311 EMBL AY725312 http://www.ebi.ac.uk/ena/data/view/AY725312 EMBL AY725313 http://www.ebi.ac.uk/ena/data/view/AY725313 EMBL AY725314 http://www.ebi.ac.uk/ena/data/view/AY725314 EMBL AY725315 http://www.ebi.ac.uk/ena/data/view/AY725315 EMBL AY725316 http://www.ebi.ac.uk/ena/data/view/AY725316 EMBL AY725317 http://www.ebi.ac.uk/ena/data/view/AY725317 EMBL AY725318 http://www.ebi.ac.uk/ena/data/view/AY725318 EMBL AY725319 http://www.ebi.ac.uk/ena/data/view/AY725319 EMBL AY725320 http://www.ebi.ac.uk/ena/data/view/AY725320 EMBL AY725321 http://www.ebi.ac.uk/ena/data/view/AY725321 EMBL AY725322 http://www.ebi.ac.uk/ena/data/view/AY725322 EMBL AY725323 http://www.ebi.ac.uk/ena/data/view/AY725323 EMBL AY725324 http://www.ebi.ac.uk/ena/data/view/AY725324 EMBL AY725325 http://www.ebi.ac.uk/ena/data/view/AY725325 EMBL AY725326 http://www.ebi.ac.uk/ena/data/view/AY725326 EMBL AY725327 http://www.ebi.ac.uk/ena/data/view/AY725327 EMBL AY725328 http://www.ebi.ac.uk/ena/data/view/AY725328 EMBL AY725329 http://www.ebi.ac.uk/ena/data/view/AY725329 EMBL AY725330 http://www.ebi.ac.uk/ena/data/view/AY725330 EMBL AY725331 http://www.ebi.ac.uk/ena/data/view/AY725331 EMBL AY725332 http://www.ebi.ac.uk/ena/data/view/AY725332 EMBL AY725333 http://www.ebi.ac.uk/ena/data/view/AY725333 EMBL D14055 http://www.ebi.ac.uk/ena/data/view/D14055 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB1572 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1572 EcoGene EG11615 http://www.ecogene.org/geneInfo.php?eg_id=EG11615 EnsemblBacteria AAC77074 http://www.ensemblgenomes.org/id/AAC77074 EnsemblBacteria AAC77074 http://www.ensemblgenomes.org/id/AAC77074 EnsemblBacteria BAE78115 http://www.ensemblgenomes.org/id/BAE78115 EnsemblBacteria BAE78115 http://www.ensemblgenomes.org/id/BAE78115 EnsemblBacteria BAE78115 http://www.ensemblgenomes.org/id/BAE78115 EnsemblBacteria b4113 http://www.ensemblgenomes.org/id/b4113 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000156 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000156 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0010041 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010041 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 948631 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948631 InParanoid P30843 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30843 IntAct P30843 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P30843* InterPro IPR001789 http://www.ebi.ac.uk/interpro/entry/IPR001789 InterPro IPR001867 http://www.ebi.ac.uk/interpro/entry/IPR001867 InterPro IPR011006 http://www.ebi.ac.uk/interpro/entry/IPR011006 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR016032 http://www.ebi.ac.uk/interpro/entry/IPR016032 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW4074 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4074 KEGG_Gene eco:b4113 http://www.genome.jp/dbget-bin/www_bget?eco:b4113 KEGG_Orthology KO:K07771 http://www.genome.jp/dbget-bin/www_bget?KO:K07771 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA SAHYSLV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SAHYSLV PROSITE PS50110 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50110 PROSITE PS51755 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51755 PSORT swissprot:BASR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BASR_ECOLI PSORT-B swissprot:BASR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BASR_ECOLI PSORT2 swissprot:BASR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BASR_ECOLI Pfam PF00072 http://pfam.xfam.org/family/PF00072 Pfam PF00486 http://pfam.xfam.org/family/PF00486 Phobius swissprot:BASR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BASR_ECOLI PhylomeDB P30843 http://phylomedb.org/?seqid=P30843 ProteinModelPortal P30843 http://www.proteinmodelportal.org/query/uniprot/P30843 PubMed 15522865 http://www.ncbi.nlm.nih.gov/pubmed/15522865 PubMed 15569938 http://www.ncbi.nlm.nih.gov/pubmed/15569938 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8282725 http://www.ncbi.nlm.nih.gov/pubmed/8282725 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418537 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418537 RefSeq WP_000697926 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000697926 SMART SM00448 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00448 SMART SM00862 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00862 SMR P30843 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P30843 STRING 511145.b4113 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4113&targetmode=cogs STRING COG0745 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0745&targetmode=cogs SUPFAM SSF46894 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46894 SUPFAM SSF52172 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52172 UniProtKB BASR_ECOLI http://www.uniprot.org/uniprot/BASR_ECOLI UniProtKB-AC P30843 http://www.uniprot.org/uniprot/P30843 charge swissprot:BASR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BASR_ECOLI eggNOG ENOG4105XJC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105XJC eggNOG ENOG4111FPD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111FPD epestfind swissprot:BASR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BASR_ECOLI garnier swissprot:BASR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BASR_ECOLI helixturnhelix swissprot:BASR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BASR_ECOLI hmoment swissprot:BASR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BASR_ECOLI iep swissprot:BASR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BASR_ECOLI inforesidue swissprot:BASR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BASR_ECOLI octanol swissprot:BASR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BASR_ECOLI pepcoil swissprot:BASR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BASR_ECOLI pepdigest swissprot:BASR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BASR_ECOLI pepinfo swissprot:BASR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BASR_ECOLI pepnet swissprot:BASR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BASR_ECOLI pepstats swissprot:BASR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BASR_ECOLI pepwheel swissprot:BASR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BASR_ECOLI pepwindow swissprot:BASR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BASR_ECOLI sigcleave swissprot:BASR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BASR_ECOLI ## Database ID URL or Descriptions # BioGrid 4261076 3 # EcoGene EG11873 fieF # FUNCTION FIEF_ECOLI Iron-efflux transporter responsible for iron detoxification. Also able to transport Zn(2+) in a proton- dependent manner. {ECO 0000269|PubMed 15549269}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015086 cadmium ion transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0015093 ferrous iron transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0015341 zinc efflux active transmembrane transporter activity; IDA:EcoCyc. # GO_process GO:0006829 zinc II ion transport; IDA:EcoCyc. # GO_process GO:0006876 cellular cadmium ion homeostasis; IDA:EcoCyc. # GO_process GO:0006882 cellular zinc ion homeostasis; IDA:EcoCyc. # GO_process GO:0010043 response to zinc ion; IBA:GO_Central. # GO_process GO:0015684 ferrous iron transport; IDA:EcoCyc. # GO_process GO:0015691 cadmium ion transport; IDA:EcoCyc. # GO_process GO:0055072 iron ion homeostasis; IEA:UniProtKB-KW. # GO_process GO:0061088 regulation of sequestering of zinc ion; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # GOslim_process GO:0042592 homeostatic process # Gene3D 1.20.1510.10 -; 1. # Gene3D 3.30.70.1350 -; 1. # HAMAP MF_01425 Cation_efflux_FieF # InterPro IPR002524 Cation_efflux # InterPro IPR023783 Cation_efflux_FieF # InterPro IPR027469 Cation_efflux_TMD # InterPro IPR027470 Cation_efflux_CTD # KEGG_Brite ko02000 Transporters # Organism FIEF_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11562 PTHR11562 # PATRIC 32123341 VBIEscCol129921_4031 # PDB 2QFI X-ray; 3.80 A; A/B=1-300 # PDB 3H90 X-ray; 2.90 A; A/B/C/D=8-290 # PIR S40858 S40858 # Pfam PF01545 Cation_efflux # Pfam PF16916 ZT_dimer # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FIEF_ECOLI Ferrous-iron efflux pump FieF # RefSeq NP_418350 NC_000913.3 # RefSeq WP_001076742 NZ_LN832404.1 # SIMILARITY Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. FieF subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION FIEF_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT Homodimer. {ECO:0000269|PubMed 15258151}. # TCDB 2.A.4.7 the cation diffusion facilitator (cdf) family # TIGRFAMs TIGR01297 CDF # eggNOG COG0053 LUCA # eggNOG ENOG41076HS Bacteria BLAST swissprot:FIEF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FIEF_ECOLI BioCyc ECOL316407:JW3886-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3886-MONOMER BioCyc EcoCyc:YIIP-MONOMER http://biocyc.org/getid?id=EcoCyc:YIIP-MONOMER BioCyc MetaCyc:YIIP-MONOMER http://biocyc.org/getid?id=MetaCyc:YIIP-MONOMER COG COG0053 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0053 DIP DIP-48564N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48564N DOI 10.1007/s00203-004-0739-4 http://dx.doi.org/10.1007/s00203-004-0739-4 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M407044200 http://dx.doi.org/10.1074/jbc.M407044200 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1819 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1819 EcoGene EG11873 http://www.ecogene.org/geneInfo.php?eg_id=EG11873 EnsemblBacteria AAC76897 http://www.ensemblgenomes.org/id/AAC76897 EnsemblBacteria AAC76897 http://www.ensemblgenomes.org/id/AAC76897 EnsemblBacteria BAE77395 http://www.ensemblgenomes.org/id/BAE77395 EnsemblBacteria BAE77395 http://www.ensemblgenomes.org/id/BAE77395 EnsemblBacteria BAE77395 http://www.ensemblgenomes.org/id/BAE77395 EnsemblBacteria b3915 http://www.ensemblgenomes.org/id/b3915 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015086 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015086 GO_function GO:0015093 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015093 GO_function GO:0015341 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015341 GO_process GO:0006829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006829 GO_process GO:0006876 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006876 GO_process GO:0006882 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006882 GO_process GO:0010043 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010043 GO_process GO:0015684 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015684 GO_process GO:0015691 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015691 GO_process GO:0055072 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055072 GO_process GO:0061088 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061088 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 Gene3D 1.20.1510.10 http://www.cathdb.info/version/latest/superfamily/1.20.1510.10 Gene3D 3.30.70.1350 http://www.cathdb.info/version/latest/superfamily/3.30.70.1350 GeneID 948413 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948413 HAMAP MF_01425 http://hamap.expasy.org/unirule/MF_01425 HOGENOM HOG000069673 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000069673&db=HOGENOM6 InParanoid P69380 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P69380 InterPro IPR002524 http://www.ebi.ac.uk/interpro/entry/IPR002524 InterPro IPR023783 http://www.ebi.ac.uk/interpro/entry/IPR023783 InterPro IPR027469 http://www.ebi.ac.uk/interpro/entry/IPR027469 InterPro IPR027470 http://www.ebi.ac.uk/interpro/entry/IPR027470 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3886 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3886 KEGG_Gene eco:b3915 http://www.genome.jp/dbget-bin/www_bget?eco:b3915 KEGG_Orthology KO:K13283 http://www.genome.jp/dbget-bin/www_bget?KO:K13283 OMA FQRWVIR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FQRWVIR PANTHER PTHR11562 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11562 PDB 2QFI http://www.ebi.ac.uk/pdbe-srv/view/entry/2QFI PDB 3H90 http://www.ebi.ac.uk/pdbe-srv/view/entry/3H90 PDBsum 2QFI http://www.ebi.ac.uk/pdbsum/2QFI PDBsum 3H90 http://www.ebi.ac.uk/pdbsum/3H90 PSORT swissprot:FIEF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FIEF_ECOLI PSORT-B swissprot:FIEF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FIEF_ECOLI PSORT2 swissprot:FIEF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FIEF_ECOLI Pfam PF01545 http://pfam.xfam.org/family/PF01545 Pfam PF16916 http://pfam.xfam.org/family/PF16916 Phobius swissprot:FIEF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FIEF_ECOLI PhylomeDB P69380 http://phylomedb.org/?seqid=P69380 ProteinModelPortal P69380 http://www.proteinmodelportal.org/query/uniprot/P69380 PubMed 15258151 http://www.ncbi.nlm.nih.gov/pubmed/15258151 PubMed 15549269 http://www.ncbi.nlm.nih.gov/pubmed/15549269 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418350 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418350 RefSeq WP_001076742 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001076742 SMR P69380 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69380 STRING 511145.b3915 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3915&targetmode=cogs STRING COG0053 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0053&targetmode=cogs TCDB 2.A.4.7 http://www.tcdb.org/search/result.php?tc=2.A.4.7 TIGRFAMs TIGR01297 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01297 UniProtKB FIEF_ECOLI http://www.uniprot.org/uniprot/FIEF_ECOLI UniProtKB-AC P69380 http://www.uniprot.org/uniprot/P69380 charge swissprot:FIEF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FIEF_ECOLI eggNOG COG0053 http://eggnogapi.embl.de/nog_data/html/tree/COG0053 eggNOG ENOG41076HS http://eggnogapi.embl.de/nog_data/html/tree/ENOG41076HS epestfind swissprot:FIEF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FIEF_ECOLI garnier swissprot:FIEF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FIEF_ECOLI helixturnhelix swissprot:FIEF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FIEF_ECOLI hmoment swissprot:FIEF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FIEF_ECOLI iep swissprot:FIEF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FIEF_ECOLI inforesidue swissprot:FIEF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FIEF_ECOLI octanol swissprot:FIEF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FIEF_ECOLI pepcoil swissprot:FIEF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FIEF_ECOLI pepdigest swissprot:FIEF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FIEF_ECOLI pepinfo swissprot:FIEF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FIEF_ECOLI pepnet swissprot:FIEF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FIEF_ECOLI pepstats swissprot:FIEF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FIEF_ECOLI pepwheel swissprot:FIEF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FIEF_ECOLI pepwindow swissprot:FIEF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FIEF_ECOLI sigcleave swissprot:FIEF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FIEF_ECOLI ## Database ID URL or Descriptions # BioGrid 4261825 9 # EcoGene EG13345 yagF # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0050401 xylonate dehydratase activity; NAS:EcoCyc. # GO_process GO:0009082 branched-chain amino acid biosynthetic process; IBA:GO_Central. # GO_process GO:0046176 aldonic acid catabolic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # InterPro IPR000581 DiOHA_6PGluconate_deHydtase # InterPro IPR015928 Aconitase/3IPM_dehydase_swvl # InterPro IPR017798 Dehydratase_YjhG/YagF # InterPro IPR020558 DiOHA_6PGluconate_deHydtase_CS # Organism YAGF_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21000 PTHR21000 # PATRIC 32115659 VBIEscCol129921_0273 # PIR E64752 E64752 # PROSITE PS00886 ILVD_EDD_1 # PROSITE PS00887 ILVD_EDD_2 # Pfam PF00920 ILVD_EDD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAGF_ECOLI Uncharacterized protein YagF # RefSeq NP_414803 NC_000913.3 # RefSeq WP_000151261 NZ_LN832404.1 # SIMILARITY Belongs to the IlvD/Edd family. {ECO 0000305}. # SUPFAM SSF52016 SSF52016 # TIGRFAMs TIGR03432 yjhG_yagF # eggNOG COG0129 LUCA # eggNOG ENOG4105C01 Bacteria BLAST swissprot:YAGF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAGF_ECOLI BioCyc ECOL316407:JW0262-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0262-MONOMER BioCyc EcoCyc:G6141-MONOMER http://biocyc.org/getid?id=EcoCyc:G6141-MONOMER BioCyc MetaCyc:G6141-MONOMER http://biocyc.org/getid?id=MetaCyc:G6141-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:4.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 ENZYME 4.-.-.- http://enzyme.expasy.org/EC/4.-.-.- EchoBASE EB3129 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3129 EcoGene EG13345 http://www.ecogene.org/geneInfo.php?eg_id=EG13345 EnsemblBacteria AAC73372 http://www.ensemblgenomes.org/id/AAC73372 EnsemblBacteria AAC73372 http://www.ensemblgenomes.org/id/AAC73372 EnsemblBacteria BAE76053 http://www.ensemblgenomes.org/id/BAE76053 EnsemblBacteria BAE76053 http://www.ensemblgenomes.org/id/BAE76053 EnsemblBacteria BAE76053 http://www.ensemblgenomes.org/id/BAE76053 EnsemblBacteria b0269 http://www.ensemblgenomes.org/id/b0269 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0050401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050401 GO_process GO:0009082 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009082 GO_process GO:0046176 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046176 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 944928 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944928 HOGENOM HOG000173155 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000173155&db=HOGENOM6 IntEnz 4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4 InterPro IPR000581 http://www.ebi.ac.uk/interpro/entry/IPR000581 InterPro IPR015928 http://www.ebi.ac.uk/interpro/entry/IPR015928 InterPro IPR017798 http://www.ebi.ac.uk/interpro/entry/IPR017798 InterPro IPR020558 http://www.ebi.ac.uk/interpro/entry/IPR020558 KEGG_Gene ecj:JW0262 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0262 KEGG_Gene eco:b0269 http://www.genome.jp/dbget-bin/www_bget?eco:b0269 OMA FDFLETS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FDFLETS PANTHER PTHR21000 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21000 PROSITE PS00886 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00886 PROSITE PS00887 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00887 PSORT swissprot:YAGF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAGF_ECOLI PSORT-B swissprot:YAGF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAGF_ECOLI PSORT2 swissprot:YAGF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAGF_ECOLI Pfam PF00920 http://pfam.xfam.org/family/PF00920 Phobius swissprot:YAGF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAGF_ECOLI PhylomeDB P77596 http://phylomedb.org/?seqid=P77596 ProteinModelPortal P77596 http://www.proteinmodelportal.org/query/uniprot/P77596 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414803 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414803 RefSeq WP_000151261 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000151261 SMR P77596 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77596 STRING 511145.b0269 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0269&targetmode=cogs SUPFAM SSF52016 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52016 TIGRFAMs TIGR03432 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03432 UniProtKB YAGF_ECOLI http://www.uniprot.org/uniprot/YAGF_ECOLI UniProtKB-AC P77596 http://www.uniprot.org/uniprot/P77596 charge swissprot:YAGF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAGF_ECOLI eggNOG COG0129 http://eggnogapi.embl.de/nog_data/html/tree/COG0129 eggNOG ENOG4105C01 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C01 epestfind swissprot:YAGF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAGF_ECOLI garnier swissprot:YAGF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAGF_ECOLI helixturnhelix swissprot:YAGF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAGF_ECOLI hmoment swissprot:YAGF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAGF_ECOLI iep swissprot:YAGF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAGF_ECOLI inforesidue swissprot:YAGF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAGF_ECOLI octanol swissprot:YAGF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAGF_ECOLI pepcoil swissprot:YAGF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAGF_ECOLI pepdigest swissprot:YAGF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAGF_ECOLI pepinfo swissprot:YAGF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAGF_ECOLI pepnet swissprot:YAGF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAGF_ECOLI pepstats swissprot:YAGF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAGF_ECOLI pepwheel swissprot:YAGF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAGF_ECOLI pepwindow swissprot:YAGF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAGF_ECOLI sigcleave swissprot:YAGF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAGF_ECOLI ## Database ID URL or Descriptions # AltName EIIA-Mtl {ECO:0000250|UniProtKB P0A0E0} # AltName EIII-Mtl {ECO:0000250|UniProtKB P0A0E0} # AltName PTS system mannitol-specific EIIA component {ECO:0000250|UniProtKB P0A0E0} # BioGrid 4261871 15 # CATALYTIC ACTIVITY [Protein]-N(pi)-phospho-L-histidine + D- mannitol(Side 1) = [protein]-L-histidine + D-mannitol 1- phosphate(Side 2). {ECO:0000250|UniProtKB P00550}. # DOMAIN PTMA_ECOLI The PTS EIIA type-2 domain is phosphorylated by phospho- HPr on a histidyl residue. Then, it transfers the phosphoryl group to the PTS EIIB type-2 domain. {ECO 0000255|PROSITE- ProRule PRU00417}. # EcoGene EG11791 cmtB # FUNCTION PTMA_ECOLI The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CmtAB PTS system is involved in D-mannitol transport. {ECO 0000250|UniProtKB P0A0E0}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0005215 transporter activity; IEA:InterPro. # GO_function GO:0016301 kinase activity; IEA:UniProtKB-KW. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; ISA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016301 kinase activity # GOslim_process GO:0006810 transport # Gene3D 3.40.930.10 -; 1. # IntAct P69824 2 # InterPro IPR002178 PTS_EIIA_type-2_dom # InterPro IPR016152 PTrfase/Anion_transptr # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00274 PTS system, mannitol-specific II component # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko00051 Fructose and mannose metabolism # KEGG_Pathway ko02060 Phosphotransferase system (PTS) # Organism PTMA_ECOLI Escherichia coli (strain K12) # PATRIC 32121280 VBIEscCol129921_3028 # PDB 2OQ3 NMR; -; A=1-147 # PIR S36122 S36122 # PROSITE PS00372 PTS_EIIA_TYPE_2_HIS # PROSITE PS51094 PTS_EIIA_TYPE_2 # Pfam PF00359 PTS_EIIA_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Mannitol-specific cryptic phosphotransferase enzyme IIA component {ECO:0000303|PubMed 8353127} # RefSeq NP_417409 NC_000913.3 # RefSeq WP_001239650 NZ_LN832404.1 # SIMILARITY Contains 1 PTS EIIA type-2 domain. {ECO:0000255|PROSITE-ProRule PRU00417}. # SUBCELLULAR LOCATION PTMA_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF55804 SSF55804 # TCDB 4.A.2.1.24 the pts fructose-mannitol (fru) family # eggNOG COG1762 LUCA # eggNOG ENOG4108X7Y Bacteria BLAST swissprot:PTMA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTMA_ECOLI BioCyc ECOL316407:JW2901-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2901-MONOMER BioCyc EcoCyc:CMTB-MONOMER http://biocyc.org/getid?id=EcoCyc:CMTB-MONOMER BioCyc MetaCyc:CMTB-MONOMER http://biocyc.org/getid?id=MetaCyc:CMTB-MONOMER COG COG1762 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1762 DOI 10.1016/0304-4165(93)90103-F http://dx.doi.org/10.1016/0304-4165(93)90103-F DOI 10.1016/j.bbrc.2007.08.102 http://dx.doi.org/10.1016/j.bbrc.2007.08.102 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.197 {ECO:0000250|UniProtKB:P00550} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.197 {ECO:0000250|UniProtKB:P00550} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EMBL X72677 http://www.ebi.ac.uk/ena/data/view/X72677 ENZYME 2.7.1.197 {ECO:0000250|UniProtKB:P00550} http://enzyme.expasy.org/EC/2.7.1.197 {ECO:0000250|UniProtKB:P00550} EchoBASE EB1739 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1739 EcoGene EG11791 http://www.ecogene.org/geneInfo.php?eg_id=EG11791 EnsemblBacteria AAC75971 http://www.ensemblgenomes.org/id/AAC75971 EnsemblBacteria AAC75971 http://www.ensemblgenomes.org/id/AAC75971 EnsemblBacteria BAE76997 http://www.ensemblgenomes.org/id/BAE76997 EnsemblBacteria BAE76997 http://www.ensemblgenomes.org/id/BAE76997 EnsemblBacteria BAE76997 http://www.ensemblgenomes.org/id/BAE76997 EnsemblBacteria b2934 http://www.ensemblgenomes.org/id/b2934 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.40.930.10 http://www.cathdb.info/version/latest/superfamily/3.40.930.10 GeneID 945125 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945125 HOGENOM HOG000227560 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000227560&db=HOGENOM6 IntAct P69824 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69824* IntEnz 2.7.1.197 {ECO:0000250|UniProtKB:P00550} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.197 {ECO:0000250|UniProtKB:P00550} InterPro IPR002178 http://www.ebi.ac.uk/interpro/entry/IPR002178 InterPro IPR016152 http://www.ebi.ac.uk/interpro/entry/IPR016152 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2901 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2901 KEGG_Gene eco:b2934 http://www.genome.jp/dbget-bin/www_bget?eco:b2934 KEGG_Orthology KO:K02798 http://www.genome.jp/dbget-bin/www_bget?KO:K02798 KEGG_Pathway ko00051 http://www.genome.jp/kegg-bin/show_pathway?ko00051 KEGG_Pathway ko02060 http://www.genome.jp/kegg-bin/show_pathway?ko02060 KEGG_Reaction rn:R02704 http://www.genome.jp/dbget-bin/www_bget?rn:R02704 OMA YKYGPYI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YKYGPYI PDB 2OQ3 http://www.ebi.ac.uk/pdbe-srv/view/entry/2OQ3 PDBsum 2OQ3 http://www.ebi.ac.uk/pdbsum/2OQ3 PROSITE PS00372 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00372 PROSITE PS51094 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51094 PSORT swissprot:PTMA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTMA_ECOLI PSORT-B swissprot:PTMA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTMA_ECOLI PSORT2 swissprot:PTMA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTMA_ECOLI Pfam PF00359 http://pfam.xfam.org/family/PF00359 Phobius swissprot:PTMA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTMA_ECOLI PhylomeDB P69824 http://phylomedb.org/?seqid=P69824 ProteinModelPortal P69824 http://www.proteinmodelportal.org/query/uniprot/P69824 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17803963 http://www.ncbi.nlm.nih.gov/pubmed/17803963 PubMed 8353127 http://www.ncbi.nlm.nih.gov/pubmed/8353127 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417409 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417409 RefSeq WP_001239650 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001239650 SMR P69824 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69824 STRING 511145.b2934 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2934&targetmode=cogs STRING COG1762 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1762&targetmode=cogs SUPFAM SSF55804 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55804 TCDB 4.A.2.1.24 http://www.tcdb.org/search/result.php?tc=4.A.2.1.24 UniProtKB PTMA_ECOLI http://www.uniprot.org/uniprot/PTMA_ECOLI UniProtKB-AC P69824 http://www.uniprot.org/uniprot/P69824 charge swissprot:PTMA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTMA_ECOLI eggNOG COG1762 http://eggnogapi.embl.de/nog_data/html/tree/COG1762 eggNOG ENOG4108X7Y http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108X7Y epestfind swissprot:PTMA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTMA_ECOLI garnier swissprot:PTMA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTMA_ECOLI helixturnhelix swissprot:PTMA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTMA_ECOLI hmoment swissprot:PTMA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTMA_ECOLI iep swissprot:PTMA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTMA_ECOLI inforesidue swissprot:PTMA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTMA_ECOLI octanol swissprot:PTMA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTMA_ECOLI pepcoil swissprot:PTMA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTMA_ECOLI pepdigest swissprot:PTMA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTMA_ECOLI pepinfo swissprot:PTMA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTMA_ECOLI pepnet swissprot:PTMA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTMA_ECOLI pepstats swissprot:PTMA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTMA_ECOLI pepwheel swissprot:PTMA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTMA_ECOLI pepwindow swissprot:PTMA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTMA_ECOLI sigcleave swissprot:PTMA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTMA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259671 7 # EcoGene EG14366 ypeB # InterPro IPR024530 QSregVF_b # Organism YPEB_ECOLI Escherichia coli (strain K12) # PATRIC 32120203 VBIEscCol129921_2504 # Pfam PF12843 QSregVF_b # ProDom PD056452 Uncharacterised_YpeB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YPEB_ECOLI Uncharacterized protein YpeB # RefSeq WP_000410201 NZ_LN832404.1 # RefSeq YP_588464 NC_000913.3 # SEQUENCE CAUTION Sequence=M24278; Type=Frameshift; Positions=45; Evidence={ECO 0000305}; # eggNOG COG3530 LUCA # eggNOG ENOG4105VRT Bacteria BLAST swissprot:YPEB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YPEB_ECOLI BioCyc ECOL316407:JW5877-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5877-MONOMER BioCyc EcoCyc:MONOMER0-2684 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2684 COG COG3530 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3530 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M24278 http://www.ebi.ac.uk/ena/data/view/M24278 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4110 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4110 EcoGene EG14366 http://www.ecogene.org/geneInfo.php?eg_id=EG14366 EnsemblBacteria ABD18696 http://www.ensemblgenomes.org/id/ABD18696 EnsemblBacteria ABD18696 http://www.ensemblgenomes.org/id/ABD18696 EnsemblBacteria BAE76710 http://www.ensemblgenomes.org/id/BAE76710 EnsemblBacteria BAE76710 http://www.ensemblgenomes.org/id/BAE76710 EnsemblBacteria BAE76710 http://www.ensemblgenomes.org/id/BAE76710 EnsemblBacteria b4546 http://www.ensemblgenomes.org/id/b4546 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1450285 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1450285 HOGENOM HOG000266648 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000266648&db=HOGENOM6 InParanoid P0AD40 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AD40 InterPro IPR024530 http://www.ebi.ac.uk/interpro/entry/IPR024530 KEGG_Gene ecj:JW5877 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5877 KEGG_Gene eco:b4546 http://www.genome.jp/dbget-bin/www_bget?eco:b4546 KEGG_Orthology KO:K09954 http://www.genome.jp/dbget-bin/www_bget?KO:K09954 OMA TMPYGKY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TMPYGKY PSORT swissprot:YPEB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YPEB_ECOLI PSORT-B swissprot:YPEB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YPEB_ECOLI PSORT2 swissprot:YPEB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YPEB_ECOLI Pfam PF12843 http://pfam.xfam.org/family/PF12843 Phobius swissprot:YPEB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YPEB_ECOLI ProteinModelPortal P0AD40 http://www.proteinmodelportal.org/query/uniprot/P0AD40 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000410201 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000410201 RefSeq YP_588464 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_588464 STRING 511145.b4546 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4546&targetmode=cogs STRING COG3530 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3530&targetmode=cogs UniProtKB YPEB_ECOLI http://www.uniprot.org/uniprot/YPEB_ECOLI UniProtKB-AC P0AD40 http://www.uniprot.org/uniprot/P0AD40 charge swissprot:YPEB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YPEB_ECOLI eggNOG COG3530 http://eggnogapi.embl.de/nog_data/html/tree/COG3530 eggNOG ENOG4105VRT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VRT epestfind swissprot:YPEB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YPEB_ECOLI garnier swissprot:YPEB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YPEB_ECOLI helixturnhelix swissprot:YPEB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YPEB_ECOLI hmoment swissprot:YPEB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YPEB_ECOLI iep swissprot:YPEB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YPEB_ECOLI inforesidue swissprot:YPEB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YPEB_ECOLI octanol swissprot:YPEB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YPEB_ECOLI pepcoil swissprot:YPEB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YPEB_ECOLI pepdigest swissprot:YPEB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YPEB_ECOLI pepinfo swissprot:YPEB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YPEB_ECOLI pepnet swissprot:YPEB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YPEB_ECOLI pepstats swissprot:YPEB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YPEB_ECOLI pepwheel swissprot:YPEB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YPEB_ECOLI pepwindow swissprot:YPEB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YPEB_ECOLI sigcleave swissprot:YPEB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YPEB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260244 61 # DISRUPTION PHENOTYPE RELB_ECOLI Essential, it cannot be deleted if a copy of relE remains in the cell. Cells missing relBE have a higher steady-state level of translation during amino acid starvation than wild-type cells. They survive antibiotic treatment in log phase better than wild-type cells. Cells missing mazE-mazF survive hydroxyurea treatment better than wild-type; further disruption of relE-relB and tonB yields even better survival (PubMed 20005847). {ECO 0000269|PubMed 11717402, ECO 0000269|PubMed 19707553, ECO 0000269|PubMed 20005847}. # DOMAIN RELB_ECOLI Dimerizes and binds DNA via its N-terminus (residues 1- 50), binds toxin RelE via the C-terminus (residues 47-79) (PubMed 18501926, PubMed 18532983). Tetramerization probably requires amino acids between residues 66 and 71 (PubMed 18501926). {ECO 0000269|PubMed 18501926, ECO 0000269|PubMed 18532983}. # EcoGene EG10836 relB # FUNCTION RELB_ECOLI Antitoxin component of a type II toxin-antitoxin (TA) module. Counteracts the effect of cognate toxin RelE via direct protein-protein interaction, preventing RelE from entering the ribosome A site and thus inhibiting its endoribonuclease activity. An autorepressor of relBE operon transcription. 2 RelB dimers bind to 2 operator sequences; DNA-binding and repression is stronger when complexed with toxin/corepressor RelE by conditional cooperativity (PubMed 18501926, PubMed 22981948). Increased transcription rate of relBE and activation of relE is consistent with a lower level of RelB in starved cells due to degradation of RelB by protease Lon. {ECO 0000269|PubMed 11274135, ECO 0000269|PubMed 11717402, ECO 0000269|PubMed 12123459, ECO 0000269|PubMed 18501926, ECO 0000269|PubMed 18532983, ECO 0000269|PubMed 19707553, ECO 0000269|PubMed 19747491, ECO 0000269|PubMed 22210768, ECO 0000269|PubMed 22981948, ECO 0000269|PubMed 9767574}. # FUNCTION RELB_ECOLI Seems to be a principal mediator of cell death in liquid media. {ECO 0000269|PubMed 19707553}. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; EXP:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # INDUCTION RELB_ECOLI By amino acid starvation, by glucose starvation and by chloramphenicol; induction is independent of ppGpp. Autorepressed by RelB, RelE acts as a corepressor (PubMed 9767574, PubMed 19747491, PubMed 18501926, PubMed 22981948). Member of the relBEF operon (PubMed 2990907). Operon induced by ectopic expression of toxins HicA, HipA, MazF, MqsR and RelE, but not by YafQ (PubMed 23432955). {ECO 0000269|PubMed 11717402, ECO 0000269|PubMed 18501926, ECO 0000269|PubMed 18532983, ECO 0000269|PubMed 19747491, ECO 0000269|PubMed 22981948, ECO 0000269|PubMed 23432955, ECO 0000269|PubMed 2990907, ECO 0000269|PubMed 9767574}. # IntAct P0C079 5 # InterPro IPR007337 RelB/DinJ # MISCELLANEOUS A number of site directed mutants give rise to a delayed relaxed phenotype; RNA synthesis resumes 10 minutes after amino acid starvation, an unusually slow recovery from periods of starvation, accumulation of a translation inhibitor. {ECO:0000303|PubMed 2990907}. # MISCELLANEOUS There are estimated to be 550-1100 RelB and 50-100 RelE molecules in rapidly growing cells of MG1655; as they have quite high affinity for each other (dissociation constant of 0.33 nM) there is probably less than 1 free RelE molecule per cell. The RelB(2)-RelE complex has a half-life of over 70 minutes. {ECO:0000269|PubMed 19747491}. # Organism RELB_ECOLI Escherichia coli (strain K12) # PATRIC 32118434 VBIEscCol129921_1637 # PDB 2K29 NMR; -; A/B=1-50 # PDB 2KC8 NMR; -; B=47-79 # PDB 4FXE X-ray; 2.75 A; A/B/C=1-79 # PIR A22830 BVECRB # PTM RELB_ECOLI Probably degraded by Lon protease during amino acid starvation (PubMed 11717402). Degraded in vitro by Lon (PubMed 19747491). {ECO 0000269|PubMed 11717402, ECO 0000269|PubMed 19747491}. # Pfam PF04221 RelB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Antitoxin RelB {ECO:0000303|PubMed 9767574} # RefSeq NP_416082 NC_000913.3 # RefSeq WP_000534858 NZ_LN832404.1 # SIMILARITY Belongs to the RelB/DinJ antitoxin family. {ECO 0000305}. # SUBUNIT RELB_ECOLI Homotetramer formed by dimerization of dimers in solution (PubMed 19747491, PubMed 18501926). Forms an RelB(2)-RelE(2) heterotetramer (PubMed 18501926, PubMed 22981948). Also forms an RelB(2)-RelE heterotrimer (PubMed 18532983, PubMed 19747491). The RelB(2)-RelE complex is probably the one that binds DNA and represses transcription, possibly as 2 heterotrimers, 1 bound to each of 2 operators (PubMed 22981948, PubMed 19747491). {ECO 0000269|PubMed 11274135, ECO 0000269|PubMed 18501926, ECO 0000269|PubMed 18532983, ECO 0000269|PubMed 19297318, ECO 0000269|PubMed 19747491, ECO 0000269|PubMed 22981948}. # TIGRFAMs TIGR02384 RelB_DinJ # eggNOG COG3077 LUCA BLAST swissprot:RELB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RELB_ECOLI BioCyc ECOL316407:JW1556-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1556-MONOMER BioCyc EcoCyc:EG10836-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10836-MONOMER BioCyc MetaCyc:EG10836-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10836-MONOMER DIP DIP-48258N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48258N DOI 10.1016/j.jmb.2008.04.039 http://dx.doi.org/10.1016/j.jmb.2008.04.039 DOI 10.1016/j.jmb.2009.09.006 http://dx.doi.org/10.1016/j.jmb.2009.09.006 DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1016/j.str.2012.08.017 http://dx.doi.org/10.1016/j.str.2012.08.017 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1998.00993.x http://dx.doi.org/10.1046/j.1365-2958.1998.00993.x DOI 10.1046/j.1365-2958.2002.03027.x http://dx.doi.org/10.1046/j.1365-2958.2002.03027.x DOI 10.1073/pnas.251327898 http://dx.doi.org/10.1073/pnas.251327898 DOI 10.1074/jbc.M809656200 http://dx.doi.org/10.1074/jbc.M809656200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1111/j.1365-2958.2008.06313.x http://dx.doi.org/10.1111/j.1365-2958.2008.06313.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.06628-11 http://dx.doi.org/10.1128/JB.06628-11 DOI 10.1128/JB.183.8.2700-2703.2001 http://dx.doi.org/10.1128/JB.183.8.2700-2703.2001 DOI 10.1186/1471-2180-13-45 http://dx.doi.org/10.1186/1471-2180-13-45 DOI 10.1371/journal.pone.0006785 http://dx.doi.org/10.1371/journal.pone.0006785 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X02405 http://www.ebi.ac.uk/ena/data/view/X02405 EchoBASE EB0829 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0829 EcoGene EG10836 http://www.ecogene.org/geneInfo.php?eg_id=EG10836 EnsemblBacteria AAC74637 http://www.ensemblgenomes.org/id/AAC74637 EnsemblBacteria AAC74637 http://www.ensemblgenomes.org/id/AAC74637 EnsemblBacteria BAA15263 http://www.ensemblgenomes.org/id/BAA15263 EnsemblBacteria BAA15263 http://www.ensemblgenomes.org/id/BAA15263 EnsemblBacteria BAA15263 http://www.ensemblgenomes.org/id/BAA15263 EnsemblBacteria b1564 http://www.ensemblgenomes.org/id/b1564 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 948308 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948308 HOGENOM HOG000008424 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000008424&db=HOGENOM6 IntAct P0C079 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0C079* InterPro IPR007337 http://www.ebi.ac.uk/interpro/entry/IPR007337 KEGG_Gene ecj:JW1556 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1556 KEGG_Gene eco:b1564 http://www.genome.jp/dbget-bin/www_bget?eco:b1564 OMA TINIRVN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TINIRVN PDB 2K29 http://www.ebi.ac.uk/pdbe-srv/view/entry/2K29 PDB 2KC8 http://www.ebi.ac.uk/pdbe-srv/view/entry/2KC8 PDB 4FXE http://www.ebi.ac.uk/pdbe-srv/view/entry/4FXE PDBsum 2K29 http://www.ebi.ac.uk/pdbsum/2K29 PDBsum 2KC8 http://www.ebi.ac.uk/pdbsum/2KC8 PDBsum 4FXE http://www.ebi.ac.uk/pdbsum/4FXE PSORT swissprot:RELB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RELB_ECOLI PSORT-B swissprot:RELB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RELB_ECOLI PSORT2 swissprot:RELB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RELB_ECOLI Pfam PF04221 http://pfam.xfam.org/family/PF04221 Phobius swissprot:RELB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RELB_ECOLI ProteinModelPortal P0C079 http://www.proteinmodelportal.org/query/uniprot/P0C079 PubMed 11274135 http://www.ncbi.nlm.nih.gov/pubmed/11274135 PubMed 11717402 http://www.ncbi.nlm.nih.gov/pubmed/11717402 PubMed 12123459 http://www.ncbi.nlm.nih.gov/pubmed/12123459 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18501926 http://www.ncbi.nlm.nih.gov/pubmed/18501926 PubMed 18532983 http://www.ncbi.nlm.nih.gov/pubmed/18532983 PubMed 19297318 http://www.ncbi.nlm.nih.gov/pubmed/19297318 PubMed 19707553 http://www.ncbi.nlm.nih.gov/pubmed/19707553 PubMed 19747491 http://www.ncbi.nlm.nih.gov/pubmed/19747491 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 22210768 http://www.ncbi.nlm.nih.gov/pubmed/22210768 PubMed 22981948 http://www.ncbi.nlm.nih.gov/pubmed/22981948 PubMed 23432955 http://www.ncbi.nlm.nih.gov/pubmed/23432955 PubMed 2990907 http://www.ncbi.nlm.nih.gov/pubmed/2990907 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9767574 http://www.ncbi.nlm.nih.gov/pubmed/9767574 RefSeq NP_416082 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416082 RefSeq WP_000534858 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000534858 SMR P0C079 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0C079 STRING 511145.b1564 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1564&targetmode=cogs TIGRFAMs TIGR02384 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02384 UniProtKB RELB_ECOLI http://www.uniprot.org/uniprot/RELB_ECOLI UniProtKB-AC P0C079 http://www.uniprot.org/uniprot/P0C079 charge swissprot:RELB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RELB_ECOLI eggNOG COG3077 http://eggnogapi.embl.de/nog_data/html/tree/COG3077 epestfind swissprot:RELB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RELB_ECOLI garnier swissprot:RELB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RELB_ECOLI helixturnhelix swissprot:RELB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RELB_ECOLI hmoment swissprot:RELB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RELB_ECOLI iep swissprot:RELB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RELB_ECOLI inforesidue swissprot:RELB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RELB_ECOLI octanol swissprot:RELB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RELB_ECOLI pepcoil swissprot:RELB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RELB_ECOLI pepdigest swissprot:RELB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RELB_ECOLI pepinfo swissprot:RELB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RELB_ECOLI pepnet swissprot:RELB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RELB_ECOLI pepstats swissprot:RELB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RELB_ECOLI pepwheel swissprot:RELB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RELB_ECOLI pepwindow swissprot:RELB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RELB_ECOLI sigcleave swissprot:RELB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RELB_ECOLI ## Database ID URL or Descriptions # AltName CSIR_ECOLI Carbon starvation induced regulator # BioGrid 4262265 4 # EcoGene EG12386 csiR # FUNCTION CSIR_ECOLI Modulates expression of csiD and lhgO in a temporal manner during entry into stationary phase or during the first few hours of carbon starvation. {ECO 0000269|PubMed 14731280}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # Gene3D 1.20.120.530 -; 1. # IntAct P37338 4 # InterPro IPR000524 Tscrpt_reg_HTH_GntR # InterPro IPR008920 TF_FadR/GntR_C # InterPro IPR011711 GntR_C # InterPro IPR011991 WHTH_DNA-bd_dom # KEGG_Brite ko03000 Transcription factors # Organism CSIR_ECOLI Escherichia coli (strain K12) # PATRIC 32120718 VBIEscCol129921_2756 # PROSITE PS50949 HTH_GNTR # Pfam PF00392 GntR # Pfam PF07729 FCD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CSIR_ECOLI HTH-type transcriptional repressor CsiR # RefSeq NP_417150 NC_000913.3 # RefSeq WP_000156811 NZ_LN832404.1 # SIMILARITY Contains 1 HTH gntR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00307}. # SMART SM00345 HTH_GNTR # SMART SM00895 FCD # SUBCELLULAR LOCATION CSIR_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF46785 SSF46785 # SUPFAM SSF48008 SSF48008 # eggNOG COG1802 LUCA # eggNOG ENOG4108PVQ Bacteria BLAST swissprot:CSIR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CSIR_ECOLI BioCyc ECOL316407:JW2639-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2639-MONOMER BioCyc EcoCyc:EG12386-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12386-MONOMER COG COG1802 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1802 DIP DIP-12095N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12095N DOI 10.1007/BF00245306 http://dx.doi.org/10.1007/BF00245306 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2003.03867.x http://dx.doi.org/10.1046/j.1365-2958.2003.03867.x DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M88334 http://www.ebi.ac.uk/ena/data/view/M88334 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2287 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2287 EcoGene EG12386 http://www.ecogene.org/geneInfo.php?eg_id=EG12386 EnsemblBacteria AAC75711 http://www.ensemblgenomes.org/id/AAC75711 EnsemblBacteria AAC75711 http://www.ensemblgenomes.org/id/AAC75711 EnsemblBacteria BAA16527 http://www.ensemblgenomes.org/id/BAA16527 EnsemblBacteria BAA16527 http://www.ensemblgenomes.org/id/BAA16527 EnsemblBacteria BAA16527 http://www.ensemblgenomes.org/id/BAA16527 EnsemblBacteria b2664 http://www.ensemblgenomes.org/id/b2664 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 1.20.120.530 http://www.cathdb.info/version/latest/superfamily/1.20.120.530 GeneID 948055 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948055 HOGENOM HOG000273992 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000273992&db=HOGENOM6 InParanoid P37338 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37338 IntAct P37338 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37338* InterPro IPR000524 http://www.ebi.ac.uk/interpro/entry/IPR000524 InterPro IPR008920 http://www.ebi.ac.uk/interpro/entry/IPR008920 InterPro IPR011711 http://www.ebi.ac.uk/interpro/entry/IPR011711 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW2639 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2639 KEGG_Gene eco:b2664 http://www.genome.jp/dbget-bin/www_bget?eco:b2664 KEGG_Orthology KO:K15735 http://www.genome.jp/dbget-bin/www_bget?KO:K15735 OMA GNENWEL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GNENWEL PROSITE PS50949 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50949 PSORT swissprot:CSIR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CSIR_ECOLI PSORT-B swissprot:CSIR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CSIR_ECOLI PSORT2 swissprot:CSIR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CSIR_ECOLI Pfam PF00392 http://pfam.xfam.org/family/PF00392 Pfam PF07729 http://pfam.xfam.org/family/PF07729 Phobius swissprot:CSIR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CSIR_ECOLI PhylomeDB P37338 http://phylomedb.org/?seqid=P37338 ProteinModelPortal P37338 http://www.proteinmodelportal.org/query/uniprot/P37338 PubMed 14731280 http://www.ncbi.nlm.nih.gov/pubmed/14731280 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 8297211 http://www.ncbi.nlm.nih.gov/pubmed/8297211 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417150 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417150 RefSeq WP_000156811 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000156811 SMART SM00345 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00345 SMART SM00895 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00895 SMR P37338 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37338 STRING 511145.b2664 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2664&targetmode=cogs STRING COG1802 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1802&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SUPFAM SSF48008 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48008 UniProtKB CSIR_ECOLI http://www.uniprot.org/uniprot/CSIR_ECOLI UniProtKB-AC P37338 http://www.uniprot.org/uniprot/P37338 charge swissprot:CSIR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CSIR_ECOLI eggNOG COG1802 http://eggnogapi.embl.de/nog_data/html/tree/COG1802 eggNOG ENOG4108PVQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108PVQ epestfind swissprot:CSIR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CSIR_ECOLI garnier swissprot:CSIR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CSIR_ECOLI helixturnhelix swissprot:CSIR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CSIR_ECOLI hmoment swissprot:CSIR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CSIR_ECOLI iep swissprot:CSIR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CSIR_ECOLI inforesidue swissprot:CSIR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CSIR_ECOLI octanol swissprot:CSIR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CSIR_ECOLI pepcoil swissprot:CSIR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CSIR_ECOLI pepdigest swissprot:CSIR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CSIR_ECOLI pepinfo swissprot:CSIR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CSIR_ECOLI pepnet swissprot:CSIR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CSIR_ECOLI pepstats swissprot:CSIR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CSIR_ECOLI pepwheel swissprot:CSIR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CSIR_ECOLI pepwindow swissprot:CSIR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CSIR_ECOLI sigcleave swissprot:CSIR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CSIR_ECOLI ## Database ID URL or Descriptions # InterPro IPR024396 Conjug_TrbD_put # Organism TRBD_ECOLI Escherichia coli (strain K12) # Pfam PF10894 DUF2689 # ProDom PD027414 PD027414 # RecName TRBD_ECOLI Protein TrbD # RefSeq NP_061459 NC_002483.1 # RefSeq WP_001443030 NZ_CP014273.1 BLAST swissprot:TRBD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRBD_ECOLI EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL U01159 http://www.ebi.ac.uk/ena/data/view/U01159 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1263494 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263494 InterPro IPR024396 http://www.ebi.ac.uk/interpro/entry/IPR024396 PSORT swissprot:TRBD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRBD_ECOLI PSORT-B swissprot:TRBD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRBD_ECOLI PSORT2 swissprot:TRBD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRBD_ECOLI Pfam PF10894 http://pfam.xfam.org/family/PF10894 Phobius swissprot:TRBD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRBD_ECOLI ProteinModelPortal P41070 http://www.proteinmodelportal.org/query/uniprot/P41070 PubMed 7915817 http://www.ncbi.nlm.nih.gov/pubmed/7915817 RefSeq NP_061459 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061459 RefSeq WP_001443030 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001443030 UniProtKB TRBD_ECOLI http://www.uniprot.org/uniprot/TRBD_ECOLI UniProtKB-AC P41070 http://www.uniprot.org/uniprot/P41070 charge swissprot:TRBD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRBD_ECOLI epestfind swissprot:TRBD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRBD_ECOLI garnier swissprot:TRBD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRBD_ECOLI helixturnhelix swissprot:TRBD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRBD_ECOLI hmoment swissprot:TRBD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRBD_ECOLI iep swissprot:TRBD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRBD_ECOLI inforesidue swissprot:TRBD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRBD_ECOLI octanol swissprot:TRBD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRBD_ECOLI pepcoil swissprot:TRBD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRBD_ECOLI pepdigest swissprot:TRBD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRBD_ECOLI pepinfo swissprot:TRBD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRBD_ECOLI pepnet swissprot:TRBD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRBD_ECOLI pepstats swissprot:TRBD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRBD_ECOLI pepwheel swissprot:TRBD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRBD_ECOLI pepwindow swissprot:TRBD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRBD_ECOLI sigcleave swissprot:TRBD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRBD_ECOLI ## Database ID URL or Descriptions # AltName LPID_ECOLI IlvGMEDA operon attenuator peptide # BioGrid 4262607 16 # EcoGene EG11270 ilvL # GO_process GO:0008652 cellular amino acid biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0009082 branched-chain amino acid biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0031555 transcriptional attenuation; IDA:EcoCyc. # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # InterPro IPR012567 IlvGEDA_leader # Organism LPID_ECOLI Escherichia coli (strain K12) # PIR A93841 LFECI # Pfam PF08046 IlvGEDA_leader # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LPID_ECOLI IlvGMEDA operon leader peptide # RefSeq NP_418215 NC_000913.3 # RefSeq WP_001311244 NZ_LN832404.1 BLAST swissprot:LPID_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LPID_ECOLI BioCyc ECOL316407:JW3739-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3739-MONOMER BioCyc EcoCyc:EG11270-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11270-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.77.4.1823 http://dx.doi.org/10.1073/pnas.77.4.1823 DOI 10.1073/pnas.78.2.922 http://dx.doi.org/10.1073/pnas.78.2.922 DOI 10.1093/nar/15.5.2137 http://dx.doi.org/10.1093/nar/15.5.2137 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M11651 http://www.ebi.ac.uk/ena/data/view/M11651 EMBL M32253 http://www.ebi.ac.uk/ena/data/view/M32253 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00289 http://www.ebi.ac.uk/ena/data/view/V00289 EMBL V00290 http://www.ebi.ac.uk/ena/data/view/V00290 EchoBASE EB1249 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1249 EcoGene EG11270 http://www.ecogene.org/geneInfo.php?eg_id=EG11270 EnsemblBacteria AAC77487 http://www.ensemblgenomes.org/id/AAC77487 EnsemblBacteria AAC77487 http://www.ensemblgenomes.org/id/AAC77487 EnsemblBacteria BAE77529 http://www.ensemblgenomes.org/id/BAE77529 EnsemblBacteria BAE77529 http://www.ensemblgenomes.org/id/BAE77529 EnsemblBacteria BAE77529 http://www.ensemblgenomes.org/id/BAE77529 EnsemblBacteria b3766 http://www.ensemblgenomes.org/id/b3766 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0008652 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008652 GO_process GO:0009082 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009082 GO_process GO:0031555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031555 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 948283 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948283 InterPro IPR012567 http://www.ebi.ac.uk/interpro/entry/IPR012567 KEGG_Gene ecj:JW3739 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3739 KEGG_Gene eco:b3766 http://www.genome.jp/dbget-bin/www_bget?eco:b3766 PSORT swissprot:LPID_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LPID_ECOLI PSORT-B swissprot:LPID_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LPID_ECOLI PSORT2 swissprot:LPID_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LPID_ECOLI Pfam PF08046 http://pfam.xfam.org/family/PF08046 Phobius swissprot:LPID_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LPID_ECOLI ProteinModelPortal P62522 http://www.proteinmodelportal.org/query/uniprot/P62522 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3550695 http://www.ncbi.nlm.nih.gov/pubmed/3550695 PubMed 3900037 http://www.ncbi.nlm.nih.gov/pubmed/3900037 PubMed 6990415 http://www.ncbi.nlm.nih.gov/pubmed/6990415 PubMed 7015336 http://www.ncbi.nlm.nih.gov/pubmed/7015336 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418215 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418215 RefSeq WP_001311244 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001311244 STRING 511145.b3766 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3766&targetmode=cogs UniProtKB LPID_ECOLI http://www.uniprot.org/uniprot/LPID_ECOLI UniProtKB-AC P62522 http://www.uniprot.org/uniprot/P62522 charge swissprot:LPID_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LPID_ECOLI epestfind swissprot:LPID_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LPID_ECOLI garnier swissprot:LPID_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LPID_ECOLI helixturnhelix swissprot:LPID_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LPID_ECOLI hmoment swissprot:LPID_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LPID_ECOLI iep swissprot:LPID_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LPID_ECOLI inforesidue swissprot:LPID_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LPID_ECOLI octanol swissprot:LPID_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LPID_ECOLI pepcoil swissprot:LPID_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LPID_ECOLI pepdigest swissprot:LPID_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LPID_ECOLI pepinfo swissprot:LPID_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LPID_ECOLI pepnet swissprot:LPID_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LPID_ECOLI pepstats swissprot:LPID_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LPID_ECOLI pepwheel swissprot:LPID_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LPID_ECOLI pepwindow swissprot:LPID_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LPID_ECOLI sigcleave swissprot:LPID_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LPID_ECOLI ## Database ID URL or Descriptions # BioGrid 4260926 10 # EcoGene EG14187 eutM # FUNCTION EUTM_ECOLI May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place. # GO_component GO:0031471 ethanolamine degradation polyhedral organelle; ISS:EcoCyc. # GO_function GO:0005198 structural molecule activity; ISS:EcoCyc. # GO_process GO:0046336 ethanolamine catabolic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0043226 organelle # GOslim_function GO:0005198 structural molecule activity # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # IntAct P0ABF4 2 # InterPro IPR000249 Microcompartment_bac # InterPro IPR020808 Bact_microcomp_CS # Organism EUTM_ECOLI Escherichia coli (strain K12) # PATHWAY EUTM_ECOLI Amine and polyamine degradation; ethanolamine degradation. # PATRIC 32120297 VBIEscCol129921_2551 # PDB 3I6P X-ray; 2.10 A; A/B/C/D/E/F=1-97 # PDB 3MPW X-ray; 2.70 A; A/B/C/D/E/F/G/H/I/J/K/L=1-97 # PDB 3MPY X-ray; 2.00 A; A=1-97 # PROSITE PS01139 BACT_MICROCOMP # Pfam PF00936 BMC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EUTM_ECOLI Ethanolamine utilization protein EutM # RefSeq NP_416952 NC_000913.3 # RefSeq WP_000387713 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial microcompartments protein family. {ECO 0000305}. # SMART SM00877 BMC # eggNOG COG4577 LUCA # eggNOG ENOG4105KNY Bacteria BLAST swissprot:EUTM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EUTM_ECOLI BioCyc ECOL316407:JW2441-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2441-MONOMER BioCyc EcoCyc:G7287-MONOMER http://biocyc.org/getid?id=EcoCyc:G7287-MONOMER COG COG4577 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4577 DIP DIP-9537N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9537N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3939 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3939 EcoGene EG14187 http://www.ecogene.org/geneInfo.php?eg_id=EG14187 EnsemblBacteria AAC75510 http://www.ensemblgenomes.org/id/AAC75510 EnsemblBacteria AAC75510 http://www.ensemblgenomes.org/id/AAC75510 EnsemblBacteria BAA16335 http://www.ensemblgenomes.org/id/BAA16335 EnsemblBacteria BAA16335 http://www.ensemblgenomes.org/id/BAA16335 EnsemblBacteria BAA16335 http://www.ensemblgenomes.org/id/BAA16335 EnsemblBacteria b2457 http://www.ensemblgenomes.org/id/b2457 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0031471 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031471 GO_function GO:0005198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005198 GO_process GO:0046336 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046336 GOslim_component GO:0043226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226 GOslim_function GO:0005198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005198 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 946942 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946942 HOGENOM HOG000286836 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000286836&db=HOGENOM6 InParanoid P0ABF4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABF4 IntAct P0ABF4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABF4* InterPro IPR000249 http://www.ebi.ac.uk/interpro/entry/IPR000249 InterPro IPR020808 http://www.ebi.ac.uk/interpro/entry/IPR020808 KEGG_Gene ecj:JW2441 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2441 KEGG_Gene eco:b2457 http://www.genome.jp/dbget-bin/www_bget?eco:b2457 KEGG_Orthology KO:K04027 http://www.genome.jp/dbget-bin/www_bget?KO:K04027 OMA PHSEVEL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PHSEVEL PDB 3I6P http://www.ebi.ac.uk/pdbe-srv/view/entry/3I6P PDB 3MPW http://www.ebi.ac.uk/pdbe-srv/view/entry/3MPW PDB 3MPY http://www.ebi.ac.uk/pdbe-srv/view/entry/3MPY PDBsum 3I6P http://www.ebi.ac.uk/pdbsum/3I6P PDBsum 3MPW http://www.ebi.ac.uk/pdbsum/3MPW PDBsum 3MPY http://www.ebi.ac.uk/pdbsum/3MPY PROSITE PS01139 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01139 PSORT swissprot:EUTM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EUTM_ECOLI PSORT-B swissprot:EUTM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EUTM_ECOLI PSORT2 swissprot:EUTM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EUTM_ECOLI Pfam PF00936 http://pfam.xfam.org/family/PF00936 Phobius swissprot:EUTM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EUTM_ECOLI PhylomeDB P0ABF4 http://phylomedb.org/?seqid=P0ABF4 ProteinModelPortal P0ABF4 http://www.proteinmodelportal.org/query/uniprot/P0ABF4 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416952 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416952 RefSeq WP_000387713 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000387713 SMART SM00877 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00877 SMR P0ABF4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABF4 STRING 511145.b2457 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2457&targetmode=cogs STRING COG4577 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4577&targetmode=cogs UniProtKB EUTM_ECOLI http://www.uniprot.org/uniprot/EUTM_ECOLI UniProtKB-AC P0ABF4 http://www.uniprot.org/uniprot/P0ABF4 charge swissprot:EUTM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EUTM_ECOLI eggNOG COG4577 http://eggnogapi.embl.de/nog_data/html/tree/COG4577 eggNOG ENOG4105KNY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KNY epestfind swissprot:EUTM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EUTM_ECOLI garnier swissprot:EUTM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EUTM_ECOLI helixturnhelix swissprot:EUTM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EUTM_ECOLI hmoment swissprot:EUTM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EUTM_ECOLI iep swissprot:EUTM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EUTM_ECOLI inforesidue swissprot:EUTM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EUTM_ECOLI octanol swissprot:EUTM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EUTM_ECOLI pepcoil swissprot:EUTM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EUTM_ECOLI pepdigest swissprot:EUTM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EUTM_ECOLI pepinfo swissprot:EUTM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EUTM_ECOLI pepnet swissprot:EUTM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EUTM_ECOLI pepstats swissprot:EUTM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EUTM_ECOLI pepwheel swissprot:EUTM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EUTM_ECOLI pepwindow swissprot:EUTM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EUTM_ECOLI sigcleave swissprot:EUTM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EUTM_ECOLI ## Database ID URL or Descriptions # AltName SODC_ECOLI Bacteriocuprein # BIOPHYSICOCHEMICAL PROPERTIES Temperature dependence Highly thermostable.; # BioGrid 4259604 8 # CATALYTIC ACTIVITY SODC_ECOLI 2 superoxide + 2 H(+) = O(2) + H(2)O(2). # CDD cd00305 Cu-Zn_Superoxide_Dismutase # COFACTOR Name=Cu cation; Xref=ChEBI:CHEBI 23378; Note=Binds 1 copper ion per subunit.; # COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI 29105; Note=Binds 1 zinc ion per subunit.; # EcoGene EG13419 sodC # FUNCTION SODC_ECOLI Destroys radicals which are normally produced within the cells and which are toxic to biological systems. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_component GO:0042597 periplasmic space; IDA:EcoliWiki. # GO_function GO:0004784 superoxide dismutase activity; IDA:EcoliWiki. # GO_function GO:0005507 copper ion binding; IDA:EcoliWiki. # GO_function GO:0008270 zinc ion binding; IDA:EcoliWiki. # GO_process GO:0006801 superoxide metabolic process; IDA:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # Gene3D 2.60.40.200 -; 1. # InterPro IPR001424 SOD_Cu_Zn_dom # InterPro IPR018152 SOD_Cu/Zn_BS # InterPro IPR024134 SOD_Cu/Zn_/chaperone # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko04146 Peroxisome # KEGG_Pathway ko05014 Amyotrophic lateral sclerosis (ALS) # KEGG_Pathway ko05016 Huntington's disease # KEGG_Pathway ko05020 Prion diseases # Organism SODC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10003 PTHR10003 # PATRIC 32118594 VBIEscCol129921_1717 # PDB 1ESO X-ray; 2.00 A; A=20-173 # PIR JC6004 JC6004 # PROSITE PS00332 SOD_CU_ZN_2 # Pfam PF00080 Sod_Cu # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SODC_ECOLI Superoxide dismutase [Cu-Zn] # RefSeq NP_416163 NC_000913.3 # RefSeq WP_001296937 NZ_LN832404.1 # SIMILARITY Belongs to the Cu-Zn superoxide dismutase family. {ECO 0000305}. # SUBCELLULAR LOCATION SODC_ECOLI Periplasm. # SUBUNIT SODC_ECOLI Monomer. # SUPFAM SSF49329 SSF49329 # eggNOG COG2032 LUCA # eggNOG ENOG4108Z7T Bacteria BLAST swissprot:SODC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SODC_ECOLI BioCyc ECOL316407:JW1638-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1638-MONOMER BioCyc EcoCyc:G6886-MONOMER http://biocyc.org/getid?id=EcoCyc:G6886-MONOMER BioCyc MetaCyc:G6886-MONOMER http://biocyc.org/getid?id=MetaCyc:G6886-MONOMER COG COG2032 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2032 DOI 10.1006/abbi.1995.1324 http://dx.doi.org/10.1006/abbi.1995.1324 DOI 10.1006/jmbi.1997.1400 http://dx.doi.org/10.1006/jmbi.1997.1400 DOI 10.1016/0014-5793(95)01106-O http://dx.doi.org/10.1016/0014-5793(95)01106-O DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj3200713 http://dx.doi.org/10.1042/bj3200713 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.15.1.1 http://www.genome.jp/dbget-bin/www_bget?EC:1.15.1.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U51242 http://www.ebi.ac.uk/ena/data/view/U51242 EMBL X97766 http://www.ebi.ac.uk/ena/data/view/X97766 ENZYME 1.15.1.1 http://enzyme.expasy.org/EC/1.15.1.1 EchoBASE EB3195 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3195 EcoGene EG13419 http://www.ecogene.org/geneInfo.php?eg_id=EG13419 EnsemblBacteria AAC74718 http://www.ensemblgenomes.org/id/AAC74718 EnsemblBacteria AAC74718 http://www.ensemblgenomes.org/id/AAC74718 EnsemblBacteria BAE76489 http://www.ensemblgenomes.org/id/BAE76489 EnsemblBacteria BAE76489 http://www.ensemblgenomes.org/id/BAE76489 EnsemblBacteria BAE76489 http://www.ensemblgenomes.org/id/BAE76489 EnsemblBacteria b1646 http://www.ensemblgenomes.org/id/b1646 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0004784 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004784 GO_function GO:0005507 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005507 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_process GO:0006801 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006801 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 2.60.40.200 http://www.cathdb.info/version/latest/superfamily/2.60.40.200 GeneID 945343 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945343 HOGENOM HOG000263449 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000263449&db=HOGENOM6 InParanoid P0AGD1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGD1 IntEnz 1.15.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.15.1.1 InterPro IPR001424 http://www.ebi.ac.uk/interpro/entry/IPR001424 InterPro IPR018152 http://www.ebi.ac.uk/interpro/entry/IPR018152 InterPro IPR024134 http://www.ebi.ac.uk/interpro/entry/IPR024134 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1638 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1638 KEGG_Gene eco:b1646 http://www.genome.jp/dbget-bin/www_bget?eco:b1646 KEGG_Orthology KO:K04565 http://www.genome.jp/dbget-bin/www_bget?KO:K04565 KEGG_Pathway ko04146 http://www.genome.jp/kegg-bin/show_pathway?ko04146 KEGG_Pathway ko05014 http://www.genome.jp/kegg-bin/show_pathway?ko05014 KEGG_Pathway ko05016 http://www.genome.jp/kegg-bin/show_pathway?ko05016 KEGG_Pathway ko05020 http://www.genome.jp/kegg-bin/show_pathway?ko05020 OMA GARYACG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GARYACG PANTHER PTHR10003 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10003 PDB 1ESO http://www.ebi.ac.uk/pdbe-srv/view/entry/1ESO PDBsum 1ESO http://www.ebi.ac.uk/pdbsum/1ESO PROSITE PS00332 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00332 PSORT swissprot:SODC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SODC_ECOLI PSORT-B swissprot:SODC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SODC_ECOLI PSORT2 swissprot:SODC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SODC_ECOLI Pfam PF00080 http://pfam.xfam.org/family/PF00080 Phobius swissprot:SODC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SODC_ECOLI PhylomeDB P0AGD1 http://phylomedb.org/?seqid=P0AGD1 ProteinModelPortal P0AGD1 http://www.proteinmodelportal.org/query/uniprot/P0AGD1 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7589534 http://www.ncbi.nlm.nih.gov/pubmed/7589534 PubMed 7786035 http://www.ncbi.nlm.nih.gov/pubmed/7786035 PubMed 7929223 http://www.ncbi.nlm.nih.gov/pubmed/7929223 PubMed 8626323 http://www.ncbi.nlm.nih.gov/pubmed/8626323 PubMed 9003353 http://www.ncbi.nlm.nih.gov/pubmed/9003353 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9405149 http://www.ncbi.nlm.nih.gov/pubmed/9405149 RefSeq NP_416163 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416163 RefSeq WP_001296937 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001296937 SMR P0AGD1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AGD1 STRING 511145.b1646 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1646&targetmode=cogs STRING COG2032 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2032&targetmode=cogs SUPFAM SSF49329 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49329 UniProtKB SODC_ECOLI http://www.uniprot.org/uniprot/SODC_ECOLI UniProtKB-AC P0AGD1 http://www.uniprot.org/uniprot/P0AGD1 charge swissprot:SODC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SODC_ECOLI eggNOG COG2032 http://eggnogapi.embl.de/nog_data/html/tree/COG2032 eggNOG ENOG4108Z7T http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Z7T epestfind swissprot:SODC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SODC_ECOLI garnier swissprot:SODC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SODC_ECOLI helixturnhelix swissprot:SODC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SODC_ECOLI hmoment swissprot:SODC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SODC_ECOLI iep swissprot:SODC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SODC_ECOLI inforesidue swissprot:SODC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SODC_ECOLI octanol swissprot:SODC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SODC_ECOLI pepcoil swissprot:SODC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SODC_ECOLI pepdigest swissprot:SODC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SODC_ECOLI pepinfo swissprot:SODC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SODC_ECOLI pepnet swissprot:SODC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SODC_ECOLI pepstats swissprot:SODC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SODC_ECOLI pepwheel swissprot:SODC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SODC_ECOLI pepwindow swissprot:SODC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SODC_ECOLI sigcleave swissprot:SODC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SODC_ECOLI ## Database ID URL or Descriptions # BioGrid 4261776 11 # BioGrid 4262083 222 # CAUTION Could be the product of a pseudogene. This sequence is interrupted by a stop codon. {ECO 0000305}. # DISRUPTION PHENOTYPE Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain. {ECO:0000269|PubMed 20345943}. # EcoGene EG14124 yfcU # FUNCTION YFCU_ECOLI Part of the yfcOPQRSUV fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes. Probably involved in the export and assembly of fimbrial subunits across the outer membrane. {ECO 0000269|PubMed 20345943}. # GO_component GO:0009279 cell outer membrane; IBA:GO_Central. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015473 fimbrial usher porin activity; IBA:GO_Central. # GO_process GO:0009297 pilus assembly; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0022607 cellular component assembly # INDUCTION Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression. {ECO:0000269|PubMed 20345943}. # IntAct P77196 20 # InterPro IPR000015 Fimb_usher # InterPro IPR018030 Fimbrial_membr_usher_CS # InterPro IPR025885 PapC_N # InterPro IPR025949 PapC-like_C # MISCELLANEOUS The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed. {ECO:0000305|PubMed 20345943}. # Organism YFCU_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30451 PTHR30451 # PATRIC 48664076 VBIEscCol107702_2379 # PIR G65006 G65006 # PIR H65006 H65006 # PROSITE PS01151 FIMBRIAL_USHER # Pfam PF00577 Usher # Pfam PF13953 PapC_C # Pfam PF13954 PapC_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFCU_ECOLI Putative outer membrane usher protein YfcU # SEQUENCE CAUTION Sequence=BAA16191.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA16192.1; Type=Erroneous termination; Positions=579; Note=Translated as Tyr.; Evidence={ECO 0000305}; Sequence=U00096; Type=Erroneous termination; Positions=579; Note=Translated as Tyr.; Evidence={ECO:0000305}; # SIMILARITY Belongs to the fimbrial export usher family. {ECO 0000305}. # SUBCELLULAR LOCATION YFCU_ECOLI Cell outer membrane {ECO 0000250}; Multi- pass membrane protein {ECO 0000250}. # eggNOG COG3188 LUCA # eggNOG ENOG4106PG1 Bacteria BLAST swissprot:YFCU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFCU_ECOLI BioCyc ECOL316407:JW2334-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2334-MONOMER BioCyc ECOL316407:JW2335-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2335-MONOMER BioCyc EcoCyc:G7208-MONOMER http://biocyc.org/getid?id=EcoCyc:G7208-MONOMER BioCyc EcoCyc:G7209-MONOMER http://biocyc.org/getid?id=EcoCyc:G7209-MONOMER DIP DIP-11989N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11989N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1462-2920.2010.02202.x http://dx.doi.org/10.1111/j.1462-2920.2010.02202.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3876 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3876 EcoGene EG14124 http://www.ecogene.org/geneInfo.php?eg_id=EG14124 EnsemblBacteria BAA16191 http://www.ensemblgenomes.org/id/BAA16191 EnsemblBacteria BAA16191 http://www.ensemblgenomes.org/id/BAA16191 EnsemblBacteria BAA16191 http://www.ensemblgenomes.org/id/BAA16191 EnsemblBacteria BAA16192 http://www.ensemblgenomes.org/id/BAA16192 EnsemblBacteria BAA16192 http://www.ensemblgenomes.org/id/BAA16192 EnsemblBacteria BAA16192 http://www.ensemblgenomes.org/id/BAA16192 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015473 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015473 GO_process GO:0009297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009297 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 HOGENOM HOG000260138 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260138&db=HOGENOM6 InParanoid P77196 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77196 IntAct P77196 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77196* InterPro IPR000015 http://www.ebi.ac.uk/interpro/entry/IPR000015 InterPro IPR018030 http://www.ebi.ac.uk/interpro/entry/IPR018030 InterPro IPR025885 http://www.ebi.ac.uk/interpro/entry/IPR025885 InterPro IPR025949 http://www.ebi.ac.uk/interpro/entry/IPR025949 KEGG_Gene ecj:JW2334 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2334 KEGG_Gene ecj:JW2335 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2335 OMA TQCEAAL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TQCEAAL PANTHER PTHR30451 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30451 PROSITE PS01151 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01151 PSORT swissprot:YFCU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFCU_ECOLI PSORT-B swissprot:YFCU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFCU_ECOLI PSORT2 swissprot:YFCU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFCU_ECOLI Pfam PF00577 http://pfam.xfam.org/family/PF00577 Pfam PF13953 http://pfam.xfam.org/family/PF13953 Pfam PF13954 http://pfam.xfam.org/family/PF13954 Phobius swissprot:YFCU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFCU_ECOLI PhylomeDB P77196 http://phylomedb.org/?seqid=P77196 ProteinModelPortal P77196 http://www.proteinmodelportal.org/query/uniprot/P77196 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20345943 http://www.ncbi.nlm.nih.gov/pubmed/20345943 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SMR P77196 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77196 STRING 316407.1799729 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.1799729&targetmode=cogs UniProtKB YFCU_ECOLI http://www.uniprot.org/uniprot/YFCU_ECOLI UniProtKB-AC P77196 http://www.uniprot.org/uniprot/P77196 charge swissprot:YFCU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFCU_ECOLI eggNOG COG3188 http://eggnogapi.embl.de/nog_data/html/tree/COG3188 eggNOG ENOG4106PG1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106PG1 epestfind swissprot:YFCU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFCU_ECOLI garnier swissprot:YFCU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFCU_ECOLI helixturnhelix swissprot:YFCU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFCU_ECOLI hmoment swissprot:YFCU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFCU_ECOLI iep swissprot:YFCU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFCU_ECOLI inforesidue swissprot:YFCU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFCU_ECOLI octanol swissprot:YFCU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFCU_ECOLI pepcoil swissprot:YFCU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFCU_ECOLI pepdigest swissprot:YFCU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFCU_ECOLI pepinfo swissprot:YFCU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFCU_ECOLI pepnet swissprot:YFCU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFCU_ECOLI pepstats swissprot:YFCU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFCU_ECOLI pepwheel swissprot:YFCU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFCU_ECOLI pepwindow swissprot:YFCU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFCU_ECOLI sigcleave swissprot:YFCU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFCU_ECOLI ## Database ID URL or Descriptions # BioGrid 4259315 24 # EcoGene EG12439 yjfF # FUNCTION YJFF_ECOLI Probably part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IBA:GO_Central. # GO_function GO:0050782 galactose uniporter activity; IDA:EcoCyc. # GO_process GO:0015757 galactose transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR001851 ABC_transp_permease # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00221 Putative simple sugar transport system # KEGG_Brite ko02000 Transporters # Organism YJFF_ECOLI Escherichia coli (strain K12) # PATRIC 32124035 VBIEscCol129921_4362 # PIR S56457 S56457 # Pfam PF02653 BPD_transp_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJFF_ECOLI Inner membrane ABC transporter permease protein YjfF # RefSeq NP_418652 NC_000913.3 # RefSeq WP_000596014 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97128.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION YJFF_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 3.A.1.2.25 the atp-binding cassette (abc) superfamily # eggNOG ENOG41062B0 Bacteria # eggNOG ENOG410XR1U LUCA BLAST swissprot:YJFF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJFF_ECOLI BioCyc ECOL316407:JW5754-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5754-MONOMER BioCyc EcoCyc:YJFF-MONOMER http://biocyc.org/getid?id=EcoCyc:YJFF-MONOMER BioCyc MetaCyc:YJFF-MONOMER http://biocyc.org/getid?id=MetaCyc:YJFF-MONOMER COG COG1079 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1079 COG COG1172 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1172 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/16.17.8707 http://dx.doi.org/10.1093/nar/16.17.8707 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X12545 http://www.ebi.ac.uk/ena/data/view/X12545 EchoBASE EB2334 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2334 EcoGene EG12439 http://www.ecogene.org/geneInfo.php?eg_id=EG12439 EnsemblBacteria AAC77188 http://www.ensemblgenomes.org/id/AAC77188 EnsemblBacteria AAC77188 http://www.ensemblgenomes.org/id/AAC77188 EnsemblBacteria BAE78231 http://www.ensemblgenomes.org/id/BAE78231 EnsemblBacteria BAE78231 http://www.ensemblgenomes.org/id/BAE78231 EnsemblBacteria BAE78231 http://www.ensemblgenomes.org/id/BAE78231 EnsemblBacteria b4231 http://www.ensemblgenomes.org/id/b4231 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0050782 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050782 GO_process GO:0015757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015757 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948754 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948754 HOGENOM HOG000212232 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000212232&db=HOGENOM6 InParanoid P37772 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37772 InterPro IPR001851 http://www.ebi.ac.uk/interpro/entry/IPR001851 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5754 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5754 KEGG_Gene eco:b4231 http://www.genome.jp/dbget-bin/www_bget?eco:b4231 KEGG_Orthology KO:K02057 http://www.genome.jp/dbget-bin/www_bget?KO:K02057 OMA LLMGCAF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LLMGCAF PSORT swissprot:YJFF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJFF_ECOLI PSORT-B swissprot:YJFF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJFF_ECOLI PSORT2 swissprot:YJFF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJFF_ECOLI Pfam PF02653 http://pfam.xfam.org/family/PF02653 Phobius swissprot:YJFF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJFF_ECOLI PhylomeDB P37772 http://phylomedb.org/?seqid=P37772 ProteinModelPortal P37772 http://www.proteinmodelportal.org/query/uniprot/P37772 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2843822 http://www.ncbi.nlm.nih.gov/pubmed/2843822 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418652 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418652 RefSeq WP_000596014 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000596014 STRING 511145.b4231 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4231&targetmode=cogs STRING COG1079 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1079&targetmode=cogs STRING COG1172 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1172&targetmode=cogs TCDB 3.A.1.2.25 http://www.tcdb.org/search/result.php?tc=3.A.1.2.25 UniProtKB YJFF_ECOLI http://www.uniprot.org/uniprot/YJFF_ECOLI UniProtKB-AC P37772 http://www.uniprot.org/uniprot/P37772 charge swissprot:YJFF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJFF_ECOLI eggNOG ENOG41062B0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41062B0 eggNOG ENOG410XR1U http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XR1U epestfind swissprot:YJFF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJFF_ECOLI garnier swissprot:YJFF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJFF_ECOLI helixturnhelix swissprot:YJFF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJFF_ECOLI hmoment swissprot:YJFF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJFF_ECOLI iep swissprot:YJFF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJFF_ECOLI inforesidue swissprot:YJFF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJFF_ECOLI octanol swissprot:YJFF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJFF_ECOLI pepcoil swissprot:YJFF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJFF_ECOLI pepdigest swissprot:YJFF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJFF_ECOLI pepinfo swissprot:YJFF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJFF_ECOLI pepnet swissprot:YJFF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJFF_ECOLI pepstats swissprot:YJFF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJFF_ECOLI pepwheel swissprot:YJFF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJFF_ECOLI pepwindow swissprot:YJFF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJFF_ECOLI sigcleave swissprot:YJFF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJFF_ECOLI ## Database ID URL or Descriptions # BioGrid 4260881 6 # EcoGene EG12368 znuB # FUNCTION ZNUB_ECOLI Involved in the high-affinity zinc uptake transport system. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IEA:InterPro. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IEA:InterPro. # GO_function GO:0042626 ATPase activity, coupled to transmembrane movement of substances; IEA:InterPro. # GO_process GO:0006829 zinc II ion transport; IEA:UniProtKB-KW. # GO_process GO:0010043 response to zinc ion; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # Gene3D 1.10.3470.10 -; 1. # InterPro IPR001626 ABC_TroCD # InterPro IPR029022 ABC_BtuC-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00242 Zinc transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism ZNUB_ECOLI Escherichia coli (strain K12) # PATRIC 32119041 VBIEscCol129921_1938 # PIR C64948 C64948 # Pfam PF00950 ABC-3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ZNUB_ECOLI High-affinity zinc uptake system membrane protein ZnuB # RefSeq NP_416373 NC_000913.3 # RefSeq WP_000571480 NZ_LN832404.1 # SIMILARITY Belongs to the ABC-3 integral membrane protein family. {ECO 0000305}. # SUBCELLULAR LOCATION ZNUB_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF81345 SSF81345 # TCDB 3.A.1.15 the atp-binding cassette (abc) superfamily # eggNOG COG1108 LUCA # eggNOG ENOG4105FAV Bacteria BLAST swissprot:ZNUB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ZNUB_ECOLI BioCyc ECOL316407:JW1848-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1848-MONOMER BioCyc EcoCyc:ZNUB-MONOMER http://biocyc.org/getid?id=EcoCyc:ZNUB-MONOMER BioCyc MetaCyc:ZNUB-MONOMER http://biocyc.org/getid?id=MetaCyc:ZNUB-MONOMER COG COG1108 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1108 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1998.00883.x http://dx.doi.org/10.1046/j.1365-2958.1998.00883.x DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M21298 http://www.ebi.ac.uk/ena/data/view/M21298 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U38702 http://www.ebi.ac.uk/ena/data/view/U38702 EchoBASE EB2271 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2271 EcoGene EG12368 http://www.ecogene.org/geneInfo.php?eg_id=EG12368 EnsemblBacteria AAC74929 http://www.ensemblgenomes.org/id/AAC74929 EnsemblBacteria AAC74929 http://www.ensemblgenomes.org/id/AAC74929 EnsemblBacteria BAA15667 http://www.ensemblgenomes.org/id/BAA15667 EnsemblBacteria BAA15667 http://www.ensemblgenomes.org/id/BAA15667 EnsemblBacteria BAA15667 http://www.ensemblgenomes.org/id/BAA15667 EnsemblBacteria b1859 http://www.ensemblgenomes.org/id/b1859 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0042626 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042626 GO_process GO:0006829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006829 GO_process GO:0010043 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010043 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.10.3470.10 http://www.cathdb.info/version/latest/superfamily/1.10.3470.10 GeneID 946372 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946372 HOGENOM HOG000181429 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000181429&db=HOGENOM6 InParanoid P39832 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39832 InterPro IPR001626 http://www.ebi.ac.uk/interpro/entry/IPR001626 InterPro IPR029022 http://www.ebi.ac.uk/interpro/entry/IPR029022 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1848 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1848 KEGG_Gene eco:b1859 http://www.genome.jp/dbget-bin/www_bget?eco:b1859 KEGG_Orthology KO:K09816 http://www.genome.jp/dbget-bin/www_bget?KO:K09816 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA GVFVVWR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GVFVVWR PSORT swissprot:ZNUB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ZNUB_ECOLI PSORT-B swissprot:ZNUB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ZNUB_ECOLI PSORT2 swissprot:ZNUB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ZNUB_ECOLI Pfam PF00950 http://pfam.xfam.org/family/PF00950 Phobius swissprot:ZNUB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ZNUB_ECOLI PhylomeDB P39832 http://phylomedb.org/?seqid=P39832 ProteinModelPortal P39832 http://www.proteinmodelportal.org/query/uniprot/P39832 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2842314 http://www.ncbi.nlm.nih.gov/pubmed/2842314 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9680209 http://www.ncbi.nlm.nih.gov/pubmed/9680209 RefSeq NP_416373 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416373 RefSeq WP_000571480 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000571480 STRING 511145.b1859 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1859&targetmode=cogs STRING COG1108 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1108&targetmode=cogs SUPFAM SSF81345 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81345 TCDB 3.A.1.15 http://www.tcdb.org/search/result.php?tc=3.A.1.15 UniProtKB ZNUB_ECOLI http://www.uniprot.org/uniprot/ZNUB_ECOLI UniProtKB-AC P39832 http://www.uniprot.org/uniprot/P39832 charge swissprot:ZNUB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ZNUB_ECOLI eggNOG COG1108 http://eggnogapi.embl.de/nog_data/html/tree/COG1108 eggNOG ENOG4105FAV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FAV epestfind swissprot:ZNUB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ZNUB_ECOLI garnier swissprot:ZNUB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ZNUB_ECOLI helixturnhelix swissprot:ZNUB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ZNUB_ECOLI hmoment swissprot:ZNUB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ZNUB_ECOLI iep swissprot:ZNUB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ZNUB_ECOLI inforesidue swissprot:ZNUB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ZNUB_ECOLI octanol swissprot:ZNUB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ZNUB_ECOLI pepcoil swissprot:ZNUB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ZNUB_ECOLI pepdigest swissprot:ZNUB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ZNUB_ECOLI pepinfo swissprot:ZNUB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ZNUB_ECOLI pepnet swissprot:ZNUB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ZNUB_ECOLI pepstats swissprot:ZNUB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ZNUB_ECOLI pepwheel swissprot:ZNUB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ZNUB_ECOLI pepwindow swissprot:ZNUB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ZNUB_ECOLI sigcleave swissprot:ZNUB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ZNUB_ECOLI ## Database ID URL or Descriptions # BioGrid 4263216 173 # DISRUPTION PHENOTYPE Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain. {ECO:0000269|PubMed 20345943}. # EcoGene EG13883 sfmD # FUNCTION SFMD_ECOLI Part of the sfmACDHF fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes. Probably involved in the export and assembly of fimbrial subunits across the outer membrane. {ECO 0000269|PubMed 20345943}. # GO_component GO:0009279 cell outer membrane; IBA:GO_Central. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015473 fimbrial usher porin activity; IBA:GO_Central. # GO_process GO:0009297 pilus assembly; IBA:GO_Central. # GO_process GO:0043711 pilus organization; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0022607 cellular component assembly # INDUCTION Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression. {ECO:0000269|PubMed 20345943}. # IntAct P77468 2 # InterPro IPR000015 Fimb_usher # InterPro IPR018030 Fimbrial_membr_usher_CS # InterPro IPR025885 PapC_N # InterPro IPR025949 PapC-like_C # KEGG_Brite ko02035 Bacterial motility proteins # MISCELLANEOUS The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed. {ECO:0000305|PubMed 20345943}. # Organism SFMD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30451 PTHR30451 # PATRIC 32116224 VBIEscCol129921_0553 # PIR C64785 C64785 # PROSITE PS01151 FIMBRIAL_USHER # Pfam PF00577 Usher # Pfam PF13953 PapC_C # Pfam PF13954 PapC_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SFMD_ECOLI Outer membrane usher protein SfmD # RefSeq NP_415065 NC_000913.3 # RefSeq WP_001333622 NZ_LN832404.1 # SIMILARITY Belongs to the fimbrial export usher family. {ECO 0000305}. # SUBCELLULAR LOCATION SFMD_ECOLI Cell outer membrane {ECO 0000250}; Multi- pass membrane protein {ECO 0000250}. # eggNOG COG3188 LUCA # eggNOG ENOG4105CW0 Bacteria BLAST swissprot:SFMD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SFMD_ECOLI BioCyc ECOL316407:JW0521-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0521-MONOMER BioCyc EcoCyc:G6292-MONOMER http://biocyc.org/getid?id=EcoCyc:G6292-MONOMER COG COG3188 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3188 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1462-2920.2010.02202.x http://dx.doi.org/10.1111/j.1462-2920.2010.02202.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EchoBASE EB3642 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3642 EcoGene EG13883 http://www.ecogene.org/geneInfo.php?eg_id=EG13883 EnsemblBacteria AAC73634 http://www.ensemblgenomes.org/id/AAC73634 EnsemblBacteria AAC73634 http://www.ensemblgenomes.org/id/AAC73634 EnsemblBacteria BAE76309 http://www.ensemblgenomes.org/id/BAE76309 EnsemblBacteria BAE76309 http://www.ensemblgenomes.org/id/BAE76309 EnsemblBacteria BAE76309 http://www.ensemblgenomes.org/id/BAE76309 EnsemblBacteria b0532 http://www.ensemblgenomes.org/id/b0532 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015473 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015473 GO_process GO:0009297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009297 GO_process GO:0043711 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043711 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GeneID 945160 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945160 HOGENOM HOG000111414 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000111414&db=HOGENOM6 InParanoid P77468 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77468 IntAct P77468 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77468* InterPro IPR000015 http://www.ebi.ac.uk/interpro/entry/IPR000015 InterPro IPR018030 http://www.ebi.ac.uk/interpro/entry/IPR018030 InterPro IPR025885 http://www.ebi.ac.uk/interpro/entry/IPR025885 InterPro IPR025949 http://www.ebi.ac.uk/interpro/entry/IPR025949 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW0521 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0521 KEGG_Gene eco:b0532 http://www.genome.jp/dbget-bin/www_bget?eco:b0532 KEGG_Orthology KO:K07354 http://www.genome.jp/dbget-bin/www_bget?KO:K07354 OMA GSASANW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GSASANW PANTHER PTHR30451 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30451 PROSITE PS01151 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01151 PSORT swissprot:SFMD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SFMD_ECOLI PSORT-B swissprot:SFMD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SFMD_ECOLI PSORT2 swissprot:SFMD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SFMD_ECOLI Pfam PF00577 http://pfam.xfam.org/family/PF00577 Pfam PF13953 http://pfam.xfam.org/family/PF13953 Pfam PF13954 http://pfam.xfam.org/family/PF13954 Phobius swissprot:SFMD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SFMD_ECOLI PhylomeDB P77468 http://phylomedb.org/?seqid=P77468 ProteinModelPortal P77468 http://www.proteinmodelportal.org/query/uniprot/P77468 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20345943 http://www.ncbi.nlm.nih.gov/pubmed/20345943 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415065 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415065 RefSeq WP_001333622 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001333622 SMR P77468 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77468 STRING 511145.b0532 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0532&targetmode=cogs STRING COG3188 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3188&targetmode=cogs UniProtKB SFMD_ECOLI http://www.uniprot.org/uniprot/SFMD_ECOLI UniProtKB-AC P77468 http://www.uniprot.org/uniprot/P77468 charge swissprot:SFMD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SFMD_ECOLI eggNOG COG3188 http://eggnogapi.embl.de/nog_data/html/tree/COG3188 eggNOG ENOG4105CW0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CW0 epestfind swissprot:SFMD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SFMD_ECOLI garnier swissprot:SFMD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SFMD_ECOLI helixturnhelix swissprot:SFMD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SFMD_ECOLI hmoment swissprot:SFMD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SFMD_ECOLI iep swissprot:SFMD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SFMD_ECOLI inforesidue swissprot:SFMD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SFMD_ECOLI octanol swissprot:SFMD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SFMD_ECOLI pepcoil swissprot:SFMD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SFMD_ECOLI pepdigest swissprot:SFMD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SFMD_ECOLI pepinfo swissprot:SFMD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SFMD_ECOLI pepnet swissprot:SFMD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SFMD_ECOLI pepstats swissprot:SFMD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SFMD_ECOLI pepwheel swissprot:SFMD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SFMD_ECOLI pepwindow swissprot:SFMD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SFMD_ECOLI sigcleave swissprot:SFMD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SFMD_ECOLI ## Database ID URL or Descriptions # BioGrid 4262776 161 # CDD cd06170 LuxR_C_like # EcoGene EG12593 yjjQ # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0051595 response to methylglyoxal; IMP:EcoCyc. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # INDUCTION YJJQ_ECOLI Repressed by H-NS, activated by LeuO. Member of the yjjQ-bglJ operon. {ECO 0000269|PubMed 18055596, ECO 0000269|PubMed 19429622}. # InterPro IPR000792 Tscrpt_reg_LuxR_C # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR016032 Sig_transdc_resp-reg_C-effctor # Organism YJJQ_ECOLI Escherichia coli (strain K12) # PATRIC 32124338 VBIEscCol129921_4512 # PIR S56592 S56592 # PROSITE PS50043 HTH_LUXR_2 # Pfam PF00196 GerE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJJQ_ECOLI Putative transcription factor YjjQ # RefSeq NP_418785 NC_000913.3 # RefSeq WP_000936635 NZ_LN832404.1 # SIMILARITY Contains 1 HTH luxR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00411}. # SMART SM00421 HTH_LUXR # SUBUNIT YJJQ_ECOLI May form homodimers. # SUPFAM SSF46894 SSF46894 # eggNOG ENOG4108N8T Bacteria # eggNOG ENOG4110JED LUCA BLAST swissprot:YJJQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJJQ_ECOLI BioCyc ECOL316407:JW4329-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4329-MONOMER BioCyc EcoCyc:G7947-MONOMER http://biocyc.org/getid?id=EcoCyc:G7947-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00108-09 http://dx.doi.org/10.1128/JB.00108-09 DOI 10.1128/JB.00807-10 http://dx.doi.org/10.1128/JB.00807-10 DOI 10.1128/JB.01447-07 http://dx.doi.org/10.1128/JB.01447-07 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2478 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2478 EcoGene EG12593 http://www.ecogene.org/geneInfo.php?eg_id=EG12593 EnsemblBacteria AAC77321 http://www.ensemblgenomes.org/id/AAC77321 EnsemblBacteria AAC77321 http://www.ensemblgenomes.org/id/AAC77321 EnsemblBacteria BAE78355 http://www.ensemblgenomes.org/id/BAE78355 EnsemblBacteria BAE78355 http://www.ensemblgenomes.org/id/BAE78355 EnsemblBacteria BAE78355 http://www.ensemblgenomes.org/id/BAE78355 EnsemblBacteria b4365 http://www.ensemblgenomes.org/id/b4365 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0051595 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051595 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 948896 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948896 HOGENOM HOG000127585 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000127585&db=HOGENOM6 InterPro IPR000792 http://www.ebi.ac.uk/interpro/entry/IPR000792 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR016032 http://www.ebi.ac.uk/interpro/entry/IPR016032 KEGG_Gene ecj:JW4329 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4329 KEGG_Gene eco:b4365 http://www.genome.jp/dbget-bin/www_bget?eco:b4365 OMA AKGWGIN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AKGWGIN PROSITE PS50043 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50043 PSORT swissprot:YJJQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJJQ_ECOLI PSORT-B swissprot:YJJQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJJQ_ECOLI PSORT2 swissprot:YJJQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJJQ_ECOLI Pfam PF00196 http://pfam.xfam.org/family/PF00196 Phobius swissprot:YJJQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJJQ_ECOLI PhylomeDB P0ADD7 http://phylomedb.org/?seqid=P0ADD7 ProteinModelPortal P0ADD7 http://www.proteinmodelportal.org/query/uniprot/P0ADD7 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18055596 http://www.ncbi.nlm.nih.gov/pubmed/18055596 PubMed 19429622 http://www.ncbi.nlm.nih.gov/pubmed/19429622 PubMed 20952573 http://www.ncbi.nlm.nih.gov/pubmed/20952573 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418785 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418785 RefSeq WP_000936635 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000936635 SMART SM00421 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00421 SMR P0ADD7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADD7 STRING 511145.b4365 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4365&targetmode=cogs SUPFAM SSF46894 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46894 UniProtKB YJJQ_ECOLI http://www.uniprot.org/uniprot/YJJQ_ECOLI UniProtKB-AC P0ADD7 http://www.uniprot.org/uniprot/P0ADD7 charge swissprot:YJJQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJJQ_ECOLI eggNOG ENOG4108N8T http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108N8T eggNOG ENOG4110JED http://eggnogapi.embl.de/nog_data/html/tree/ENOG4110JED epestfind swissprot:YJJQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJJQ_ECOLI garnier swissprot:YJJQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJJQ_ECOLI helixturnhelix swissprot:YJJQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJJQ_ECOLI hmoment swissprot:YJJQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJJQ_ECOLI iep swissprot:YJJQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJJQ_ECOLI inforesidue swissprot:YJJQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJJQ_ECOLI octanol swissprot:YJJQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJJQ_ECOLI pepcoil swissprot:YJJQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJJQ_ECOLI pepdigest swissprot:YJJQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJJQ_ECOLI pepinfo swissprot:YJJQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJJQ_ECOLI pepnet swissprot:YJJQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJJQ_ECOLI pepstats swissprot:YJJQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJJQ_ECOLI pepwheel swissprot:YJJQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJJQ_ECOLI pepwindow swissprot:YJJQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJJQ_ECOLI sigcleave swissprot:YJJQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJJQ_ECOLI ## Database ID URL or Descriptions # AltName GARP_ECOLI D-galactarate permease # BioGrid 4259486 14 # CDD cd06174 MFS # EcoGene EG12760 garP # FUNCTION GARP_ECOLI Uptake of D-galactarate. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IBA:GO_Central. # GO_function GO:0022857 transmembrane transporter activity; IBA:GO_Central. # GO_process GO:0006820 anion transport; IBA:GO_Central. # GO_process GO:0055085 transmembrane transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # InterPro IPR000849 Sugar_P_transporter # InterPro IPR004744 Dgal_transporter # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # KEGG_Brite ko02000 Transporters # Organism GARP_ECOLI Escherichia coli (strain K12) # PATRIC 32121668 VBIEscCol129921_3220 # PIR C65102 C65102 # PIRSF PIRSF002808 Hexose_phosphate_transp # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GARP_ECOLI Probable galactarate transporter # RefSeq NP_417596 NC_000913.3 # RefSeq WP_000599636 NZ_LN832404.1 # SIMILARITY Belongs to the major facilitator superfamily. Phthalate permease family. {ECO 0000305}. # SUBCELLULAR LOCATION GARP_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF103473 SSF103473 # TIGRFAMs TIGR00893 2A0114 # eggNOG ENOG4105DJB Bacteria # eggNOG ENOG410XPWC LUCA BLAST swissprot:GARP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GARP_ECOLI BioCyc ECOL316407:JW3096-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3096-MONOMER BioCyc EcoCyc:YHAU-MONOMER http://biocyc.org/getid?id=EcoCyc:YHAU-MONOMER BioCyc MetaCyc:YHAU-MONOMER http://biocyc.org/getid?id=MetaCyc:YHAU-MONOMER COG COG0477 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0477 DOI 10.1021/bi981124f http://dx.doi.org/10.1021/bi981124f DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.9.2672-2674.2000 http://dx.doi.org/10.1128/JB.182.9.2672-2674.2000 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2613 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2613 EcoGene EG12760 http://www.ecogene.org/geneInfo.php?eg_id=EG12760 EnsemblBacteria AAC76161 http://www.ensemblgenomes.org/id/AAC76161 EnsemblBacteria AAC76161 http://www.ensemblgenomes.org/id/AAC76161 EnsemblBacteria BAE77174 http://www.ensemblgenomes.org/id/BAE77174 EnsemblBacteria BAE77174 http://www.ensemblgenomes.org/id/BAE77174 EnsemblBacteria BAE77174 http://www.ensemblgenomes.org/id/BAE77174 EnsemblBacteria b3127 http://www.ensemblgenomes.org/id/b3127 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GO_process GO:0006820 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006820 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 947642 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947642 HOGENOM HOG000113642 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000113642&db=HOGENOM6 InParanoid P0AA80 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AA80 InterPro IPR000849 http://www.ebi.ac.uk/interpro/entry/IPR000849 InterPro IPR004744 http://www.ebi.ac.uk/interpro/entry/IPR004744 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3096 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3096 KEGG_Gene eco:b3127 http://www.genome.jp/dbget-bin/www_bget?eco:b3127 KEGG_Orthology KO:K12299 http://www.genome.jp/dbget-bin/www_bget?KO:K12299 OMA QTPAMAV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QTPAMAV PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:GARP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GARP_ECOLI PSORT-B swissprot:GARP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GARP_ECOLI PSORT2 swissprot:GARP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GARP_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:GARP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GARP_ECOLI PhylomeDB P0AA80 http://phylomedb.org/?seqid=P0AA80 ProteinModelPortal P0AA80 http://www.proteinmodelportal.org/query/uniprot/P0AA80 PubMed 10762278 http://www.ncbi.nlm.nih.gov/pubmed/10762278 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9772162 http://www.ncbi.nlm.nih.gov/pubmed/9772162 RefSeq NP_417596 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417596 RefSeq WP_000599636 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000599636 STRING 511145.b3127 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3127&targetmode=cogs STRING COG0477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0477&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TIGRFAMs TIGR00893 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00893 UniProtKB GARP_ECOLI http://www.uniprot.org/uniprot/GARP_ECOLI UniProtKB-AC P0AA80 http://www.uniprot.org/uniprot/P0AA80 charge swissprot:GARP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GARP_ECOLI eggNOG ENOG4105DJB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DJB eggNOG ENOG410XPWC http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPWC epestfind swissprot:GARP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GARP_ECOLI garnier swissprot:GARP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GARP_ECOLI helixturnhelix swissprot:GARP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GARP_ECOLI hmoment swissprot:GARP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GARP_ECOLI iep swissprot:GARP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GARP_ECOLI inforesidue swissprot:GARP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GARP_ECOLI octanol swissprot:GARP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GARP_ECOLI pepcoil swissprot:GARP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GARP_ECOLI pepdigest swissprot:GARP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GARP_ECOLI pepinfo swissprot:GARP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GARP_ECOLI pepnet swissprot:GARP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GARP_ECOLI pepstats swissprot:GARP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GARP_ECOLI pepwheel swissprot:GARP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GARP_ECOLI pepwindow swissprot:GARP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GARP_ECOLI sigcleave swissprot:GARP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GARP_ECOLI ## Database ID URL or Descriptions # BioGrid 4259785 121 # CATALYTIC ACTIVITY YAGS_ECOLI Hypoxanthine + NAD(+) + H(2)O = xanthine + NADH. # CATALYTIC ACTIVITY YAGS_ECOLI Xanthine + NAD(+) + H(2)O = urate + NADH. # COFACTOR Name=FAD; Xref=ChEBI:CHEBI 57692; Evidence={ECO:0000250}; # EcoGene EG13558 yagS # GO_component GO:0042597 periplasmic space; NAS:EcoCyc. # GO_function GO:0004854 xanthine dehydrogenase activity; IEA:UniProtKB-EC. # GO_function GO:0016614 oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro. # GO_function GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors; IDA:EcoCyc. # GO_function GO:0050660 flavin adenine dinucleotide binding; IDA:EcoCyc. # GO_process GO:0006144 purine nucleobase metabolic process; IEA:UniProtKB-KW. # GO_process GO:0006166 purine ribonucleoside salvage; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.30.43.10 -; 1. # Gene3D 3.30.465.10 -; 2. # IntAct P77324 7 # InterPro IPR002346 Mopterin_DH_FAD-bd # InterPro IPR005107 CO_DH_flav_C # InterPro IPR016166 FAD-bd_2 # InterPro IPR016167 FAD-bd_2_sub1 # InterPro IPR016169 CO_DH_flavot_FAD-bd_sub2 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # Organism YAGS_ECOLI Escherichia coli (strain K12) # PATRIC 32115693 VBIEscCol129921_0289 # PDB 5G5G X-ray; 1.70 A; B=1-318 # PDB 5G5H X-ray; 2.30 A; B=1-318 # PIR E64754 E64754 # PROSITE PS51387 FAD_PCMH # Pfam PF00941 FAD_binding_5 # Pfam PF03450 CO_deh_flav_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAGS_ECOLI Putative xanthine dehydrogenase YagS FAD-binding subunit # RefSeq NP_414819 NC_000913.3 # RefSeq WP_000643333 NZ_LN832404.1 # SIMILARITY Contains 1 FAD-binding PCMH-type domain. {ECO:0000255|PROSITE-ProRule PRU00718}. # SMART SM01092 CO_deh_flav_C # SUBUNIT Heterotrimer of YagR, YagS and YagT. {ECO 0000305}. # SUPFAM SSF55447 SSF55447 # SUPFAM SSF56176 SSF56176 # eggNOG COG1319 LUCA # eggNOG ENOG4105DIP Bacteria BLAST swissprot:YAGS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAGS_ECOLI BioCyc ECOL316407:JW0279-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0279-MONOMER BioCyc EcoCyc:G6156-MONOMER http://biocyc.org/getid?id=EcoCyc:G6156-MONOMER BioCyc MetaCyc:G6156-MONOMER http://biocyc.org/getid?id=MetaCyc:G6156-MONOMER COG COG1319 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1319 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.17.1.4 http://www.genome.jp/dbget-bin/www_bget?EC:1.17.1.4 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 ENZYME 1.17.1.4 http://enzyme.expasy.org/EC/1.17.1.4 EchoBASE EB3328 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3328 EcoGene EG13558 http://www.ecogene.org/geneInfo.php?eg_id=EG13558 EnsemblBacteria AAC73388 http://www.ensemblgenomes.org/id/AAC73388 EnsemblBacteria AAC73388 http://www.ensemblgenomes.org/id/AAC73388 EnsemblBacteria BAE76069 http://www.ensemblgenomes.org/id/BAE76069 EnsemblBacteria BAE76069 http://www.ensemblgenomes.org/id/BAE76069 EnsemblBacteria BAE76069 http://www.ensemblgenomes.org/id/BAE76069 EnsemblBacteria b0285 http://www.ensemblgenomes.org/id/b0285 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0004854 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004854 GO_function GO:0016614 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016614 GO_function GO:0016903 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016903 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_process GO:0006144 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006144 GO_process GO:0006166 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006166 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.30.43.10 http://www.cathdb.info/version/latest/superfamily/3.30.43.10 Gene3D 3.30.465.10 http://www.cathdb.info/version/latest/superfamily/3.30.465.10 GeneID 945710 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945710 HOGENOM HOG000244727 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000244727&db=HOGENOM6 InParanoid P77324 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77324 IntAct P77324 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77324* IntEnz 1.17.1.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.17.1.4 InterPro IPR002346 http://www.ebi.ac.uk/interpro/entry/IPR002346 InterPro IPR005107 http://www.ebi.ac.uk/interpro/entry/IPR005107 InterPro IPR016166 http://www.ebi.ac.uk/interpro/entry/IPR016166 InterPro IPR016167 http://www.ebi.ac.uk/interpro/entry/IPR016167 InterPro IPR016169 http://www.ebi.ac.uk/interpro/entry/IPR016169 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0279 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0279 KEGG_Gene eco:b0285 http://www.genome.jp/dbget-bin/www_bget?eco:b0285 KEGG_Orthology KO:K11178 http://www.genome.jp/dbget-bin/www_bget?KO:K11178 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Reaction rn:R01768 http://www.genome.jp/dbget-bin/www_bget?rn:R01768 KEGG_Reaction rn:R02103 http://www.genome.jp/dbget-bin/www_bget?rn:R02103 OMA GGTHIYR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GGTHIYR PDB 5G5G http://www.ebi.ac.uk/pdbe-srv/view/entry/5G5G PDB 5G5H http://www.ebi.ac.uk/pdbe-srv/view/entry/5G5H PDBsum 5G5G http://www.ebi.ac.uk/pdbsum/5G5G PDBsum 5G5H http://www.ebi.ac.uk/pdbsum/5G5H PROSITE PS51387 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51387 PSORT swissprot:YAGS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAGS_ECOLI PSORT-B swissprot:YAGS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAGS_ECOLI PSORT2 swissprot:YAGS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAGS_ECOLI Pfam PF00941 http://pfam.xfam.org/family/PF00941 Pfam PF03450 http://pfam.xfam.org/family/PF03450 Phobius swissprot:YAGS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAGS_ECOLI PhylomeDB P77324 http://phylomedb.org/?seqid=P77324 ProteinModelPortal P77324 http://www.proteinmodelportal.org/query/uniprot/P77324 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414819 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414819 RefSeq WP_000643333 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000643333 SMART SM01092 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01092 STRING 511145.b0285 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0285&targetmode=cogs STRING COG1319 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1319&targetmode=cogs SUPFAM SSF55447 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55447 SUPFAM SSF56176 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56176 UniProtKB YAGS_ECOLI http://www.uniprot.org/uniprot/YAGS_ECOLI UniProtKB-AC P77324 http://www.uniprot.org/uniprot/P77324 charge swissprot:YAGS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAGS_ECOLI eggNOG COG1319 http://eggnogapi.embl.de/nog_data/html/tree/COG1319 eggNOG ENOG4105DIP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DIP epestfind swissprot:YAGS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAGS_ECOLI garnier swissprot:YAGS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAGS_ECOLI helixturnhelix swissprot:YAGS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAGS_ECOLI hmoment swissprot:YAGS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAGS_ECOLI iep swissprot:YAGS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAGS_ECOLI inforesidue swissprot:YAGS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAGS_ECOLI octanol swissprot:YAGS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAGS_ECOLI pepcoil swissprot:YAGS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAGS_ECOLI pepdigest swissprot:YAGS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAGS_ECOLI pepinfo swissprot:YAGS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAGS_ECOLI pepnet swissprot:YAGS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAGS_ECOLI pepstats swissprot:YAGS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAGS_ECOLI pepwheel swissprot:YAGS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAGS_ECOLI pepwindow swissprot:YAGS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAGS_ECOLI sigcleave swissprot:YAGS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAGS_ECOLI ## Database ID URL or Descriptions # BioGrid 4260037 11 # DISRUPTION PHENOTYPE No effect on SecY degradation. {ECO:0000269|PubMed 9636708}. # EcoGene EG11113 yccA # FUNCTION YCCA_ECOLI Negatively modulates the activity of the FtsH protease for membrane substrates. Overexpression or stabilizing YccA counteracts the FtsH-mediated degradation of SecY when the SecYEG preprotein translocator is jammed. {ECO 0000269|PubMed 19661432}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IDA:EcoCyc. # GO_process GO:0030162 regulation of proteolysis; IMP:EcoCyc. # GO_process GO:0043066 negative regulation of apoptotic process; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0008150 biological_process # INDUCTION Regulated in a Cpx-dependent fashion. {ECO:0000269|PubMed 19661432}. # InterPro IPR006213 Bax_inhbtr1_CS # InterPro IPR006214 Bax_inhibitor_1-related # Organism YCCA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR23291 PTHR23291 # PATRIC 32117161 VBIEscCol129921_1005 # PIR S07180 S07180 # PROSITE PS01243 BI1 # PTM YCCA_ECOLI YccA is processively degraded by FtsH; degradation initiates via the approximately 20 residue N-terminal tail in a sequence non-specific manner. The deletion mutant yccA11 is resistant to FtsH-mediated degradation, probably because it is too short to be degraded by FtsH. # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCCA_ECOLI Modulator of FtsH protease YccA # RefSeq NP_415490 NC_000913.3 # RefSeq WP_000375136 NZ_LN832404.1 # SIMILARITY Belongs to the BI1 family. {ECO 0000305}. # SUBCELLULAR LOCATION YCCA_ECOLI Cell inner membrane; Multi-pass membrane protein. Note=There are conflicting results regarding the localization of the C-terminus of this protein According to a report, the C-terminus localizes in the periplasm (PubMed 10357810). Another report gives the C-terminus in the cytoplasm (PubMed 15919996). We show the periplasmic location. {ECO 0000269|PubMed 10357810, ECO 0000269|PubMed 15919996}. # SUBUNIT YCCA_ECOLI Both wild-type and the yccA11 mutant interact with the FtsH/HflKC complex. # TCDB 1.A.14.2 the testis-enhanced gene transfer (tegt) family # eggNOG COG0670 LUCA # eggNOG ENOG4108MN8 Bacteria BLAST swissprot:YCCA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCCA_ECOLI BioCyc ECOL316407:JW0953-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0953-MONOMER BioCyc EcoCyc:EG11113-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11113-MONOMER COG COG0670 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0670 DIP DIP-47918N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47918N DOI 10.1006/jmbi.1998.1781 http://dx.doi.org/10.1006/jmbi.1998.1781 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/emboj/18.11.2970 http://dx.doi.org/10.1093/emboj/18.11.2970 DOI 10.1093/jb/mvp071 http://dx.doi.org/10.1093/jb/mvp071 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.1172221 http://dx.doi.org/10.1126/science.1172221 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X00547 http://www.ebi.ac.uk/ena/data/view/X00547 EchoBASE EB1104 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1104 EcoGene EG11113 http://www.ecogene.org/geneInfo.php?eg_id=EG11113 EnsemblBacteria AAC74056 http://www.ensemblgenomes.org/id/AAC74056 EnsemblBacteria AAC74056 http://www.ensemblgenomes.org/id/AAC74056 EnsemblBacteria BAA35735 http://www.ensemblgenomes.org/id/BAA35735 EnsemblBacteria BAA35735 http://www.ensemblgenomes.org/id/BAA35735 EnsemblBacteria BAA35735 http://www.ensemblgenomes.org/id/BAA35735 EnsemblBacteria b0970 http://www.ensemblgenomes.org/id/b0970 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0030162 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030162 GO_process GO:0043066 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043066 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 946016 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946016 HOGENOM HOG000060391 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000060391&db=HOGENOM6 InParanoid P0AAC6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAC6 IntAct P0AAC6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAC6* InterPro IPR006213 http://www.ebi.ac.uk/interpro/entry/IPR006213 InterPro IPR006214 http://www.ebi.ac.uk/interpro/entry/IPR006214 KEGG_Gene ecj:JW0953 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0953 KEGG_Gene eco:b0970 http://www.genome.jp/dbget-bin/www_bget?eco:b0970 KEGG_Orthology KO:K06890 http://www.genome.jp/dbget-bin/www_bget?KO:K06890 MINT MINT-1274885 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1274885 OMA MAMNLPR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MAMNLPR PANTHER PTHR23291 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23291 PROSITE PS01243 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01243 PSORT swissprot:YCCA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCCA_ECOLI PSORT-B swissprot:YCCA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCCA_ECOLI PSORT2 swissprot:YCCA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCCA_ECOLI Phobius swissprot:YCCA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCCA_ECOLI PhylomeDB P0AAC6 http://phylomedb.org/?seqid=P0AAC6 ProteinModelPortal P0AAC6 http://www.proteinmodelportal.org/query/uniprot/P0AAC6 PubMed 10357810 http://www.ncbi.nlm.nih.gov/pubmed/10357810 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19454621 http://www.ncbi.nlm.nih.gov/pubmed/19454621 PubMed 19661432 http://www.ncbi.nlm.nih.gov/pubmed/19661432 PubMed 6376117 http://www.ncbi.nlm.nih.gov/pubmed/6376117 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9636708 http://www.ncbi.nlm.nih.gov/pubmed/9636708 RefSeq NP_415490 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415490 RefSeq WP_000375136 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000375136 STRING 511145.b0970 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0970&targetmode=cogs STRING COG0670 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0670&targetmode=cogs TCDB 1.A.14.2 http://www.tcdb.org/search/result.php?tc=1.A.14.2 UniProtKB YCCA_ECOLI http://www.uniprot.org/uniprot/YCCA_ECOLI UniProtKB-AC P0AAC6 http://www.uniprot.org/uniprot/P0AAC6 charge swissprot:YCCA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCCA_ECOLI eggNOG COG0670 http://eggnogapi.embl.de/nog_data/html/tree/COG0670 eggNOG ENOG4108MN8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MN8 epestfind swissprot:YCCA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCCA_ECOLI garnier swissprot:YCCA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCCA_ECOLI helixturnhelix swissprot:YCCA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCCA_ECOLI hmoment swissprot:YCCA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCCA_ECOLI iep swissprot:YCCA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCCA_ECOLI inforesidue swissprot:YCCA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCCA_ECOLI octanol swissprot:YCCA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCCA_ECOLI pepcoil swissprot:YCCA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCCA_ECOLI pepdigest swissprot:YCCA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCCA_ECOLI pepinfo swissprot:YCCA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCCA_ECOLI pepnet swissprot:YCCA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCCA_ECOLI pepstats swissprot:YCCA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCCA_ECOLI pepwheel swissprot:YCCA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCCA_ECOLI pepwindow swissprot:YCCA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCCA_ECOLI sigcleave swissprot:YCCA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCCA_ECOLI ## Database ID URL or Descriptions # AltName LHR_ECOLI Large helicase-related protein # BioGrid 4260268 62 # EcoGene EG11548 lhr # GO_function GO:0003676 nucleic acid binding; IEA:InterPro. # GO_function GO:0004386 helicase activity; IEA:UniProtKB-KW. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0004386 helicase activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.300 -; 3. # IntAct P30015 9 # InterPro IPR001650 Helicase_C # InterPro IPR003593 AAA+_ATPase # InterPro IPR011545 DEAD/DEAH_box_helicase_dom # InterPro IPR013701 DEAD/DEAH_assoc # InterPro IPR014001 Helicase_ATP-bd # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # Organism LHR_ECOLI Escherichia coli (strain K12) # PATRIC 32118608 VBIEscCol129921_1724 # PIR G64922 G64922 # PROSITE PS51192 HELICASE_ATP_BIND_1 # PROSITE PS51194 HELICASE_CTER # Pfam PF00270 DEAD # Pfam PF00271 Helicase_C # Pfam PF08494 DEAD_assoc # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LHR_ECOLI Probable ATP-dependent helicase lhr # RefSeq NP_416170 NC_000913.3 # RefSeq WP_001310858 NZ_LN832404.1 # SIMILARITY Belongs to the helicase family. {ECO 0000305}. # SIMILARITY Contains 1 helicase ATP-binding domain. {ECO:0000255|PROSITE-ProRule PRU00541}. # SIMILARITY Contains 1 helicase C-terminal domain. {ECO:0000255|PROSITE-ProRule PRU00542}. # SMART SM00382 AAA # SMART SM00487 DEXDc # SMART SM00490 HELICc # SUPFAM SSF52540 SSF52540; 3 # eggNOG COG1201 LUCA # eggNOG ENOG4107QRT Bacteria BLAST swissprot:LHR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LHR_ECOLI BioCyc ECOL316407:JW1645-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1645-MONOMER BioCyc EcoCyc:EG11548-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11548-MONOMER COG COG1201 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1201 DIP DIP-10097N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10097N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.4.- http://www.genome.jp/dbget-bin/www_bget?EC:3.6.4.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L01622 http://www.ebi.ac.uk/ena/data/view/L01622 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.6.4.- http://enzyme.expasy.org/EC/3.6.4.- EchoBASE EB1510 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1510 EcoGene EG11548 http://www.ecogene.org/geneInfo.php?eg_id=EG11548 EnsemblBacteria AAC74725 http://www.ensemblgenomes.org/id/AAC74725 EnsemblBacteria AAC74725 http://www.ensemblgenomes.org/id/AAC74725 EnsemblBacteria BAA15419 http://www.ensemblgenomes.org/id/BAA15419 EnsemblBacteria BAA15419 http://www.ensemblgenomes.org/id/BAA15419 EnsemblBacteria BAA15419 http://www.ensemblgenomes.org/id/BAA15419 EnsemblBacteria b1653 http://www.ensemblgenomes.org/id/b1653 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003676 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003676 GO_function GO:0004386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004386 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0004386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004386 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 946156 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946156 HOGENOM HOG000238716 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000238716&db=HOGENOM6 InParanoid P30015 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30015 IntAct P30015 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P30015* IntEnz 3.6.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.4 InterPro IPR001650 http://www.ebi.ac.uk/interpro/entry/IPR001650 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR011545 http://www.ebi.ac.uk/interpro/entry/IPR011545 InterPro IPR013701 http://www.ebi.ac.uk/interpro/entry/IPR013701 InterPro IPR014001 http://www.ebi.ac.uk/interpro/entry/IPR014001 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW1645 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1645 KEGG_Gene eco:b1653 http://www.genome.jp/dbget-bin/www_bget?eco:b1653 KEGG_Orthology KO:K03724 http://www.genome.jp/dbget-bin/www_bget?KO:K03724 MINT MINT-1293547 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1293547 OMA RYGVVFW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RYGVVFW PROSITE PS51192 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51192 PROSITE PS51194 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51194 PSORT swissprot:LHR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LHR_ECOLI PSORT-B swissprot:LHR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LHR_ECOLI PSORT2 swissprot:LHR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LHR_ECOLI Pfam PF00270 http://pfam.xfam.org/family/PF00270 Pfam PF00271 http://pfam.xfam.org/family/PF00271 Pfam PF08494 http://pfam.xfam.org/family/PF08494 Phobius swissprot:LHR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LHR_ECOLI PhylomeDB P30015 http://phylomedb.org/?seqid=P30015 ProteinModelPortal P30015 http://www.proteinmodelportal.org/query/uniprot/P30015 PubMed 1460056 http://www.ncbi.nlm.nih.gov/pubmed/1460056 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7559321 http://www.ncbi.nlm.nih.gov/pubmed/7559321 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416170 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416170 RefSeq WP_001310858 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001310858 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMART SM00487 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00487 SMART SM00490 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00490 STRING 511145.b1653 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1653&targetmode=cogs STRING COG1201 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1201&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB LHR_ECOLI http://www.uniprot.org/uniprot/LHR_ECOLI UniProtKB-AC P30015 http://www.uniprot.org/uniprot/P30015 charge swissprot:LHR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LHR_ECOLI eggNOG COG1201 http://eggnogapi.embl.de/nog_data/html/tree/COG1201 eggNOG ENOG4107QRT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QRT epestfind swissprot:LHR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LHR_ECOLI garnier swissprot:LHR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LHR_ECOLI helixturnhelix swissprot:LHR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LHR_ECOLI hmoment swissprot:LHR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LHR_ECOLI iep swissprot:LHR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LHR_ECOLI inforesidue swissprot:LHR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LHR_ECOLI octanol swissprot:LHR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LHR_ECOLI pepcoil swissprot:LHR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LHR_ECOLI pepdigest swissprot:LHR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LHR_ECOLI pepinfo swissprot:LHR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LHR_ECOLI pepnet swissprot:LHR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LHR_ECOLI pepstats swissprot:LHR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LHR_ECOLI pepwheel swissprot:LHR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LHR_ECOLI pepwindow swissprot:LHR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LHR_ECOLI sigcleave swissprot:LHR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LHR_ECOLI ## Database ID URL or Descriptions # BioGrid 4261414 14 # EcoGene EG11292 yghA # GO_function GO:0008106 alcohol dehydrogenase (NADP+) activity; IDA:EcoCyc. # GOslim_function GO:0016491 oxidoreductase activity # Gene3D 3.40.50.720 -; 1. # IntAct P0AG84 6 # InterPro IPR002347 SDR_fam # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR020904 Sc_DH/Rdtase_CS # KEGG_Brite ko01000 Enzymes # Organism YGHA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR24322 PTHR24322; 2 # PATRIC 32121424 VBIEscCol129921_3099 # PIR A65087 A65087 # PRINTS PR00080 SDRFAMILY # PRINTS PR00081 GDHRDH # PROSITE PS00061 ADH_SHORT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGHA_ECOLI Uncharacterized oxidoreductase YghA # RefSeq NP_417476 NC_000913.3 # RefSeq WP_000018760 NZ_LN832404.1 # SIMILARITY Belongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO 0000305}. # SUPFAM SSF51735 SSF51735 # eggNOG ENOG4105CYX Bacteria # eggNOG ENOG410XNUN LUCA BLAST swissprot:YGHA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGHA_ECOLI BioCyc ECOL316407:JW2972-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2972-MONOMER BioCyc EcoCyc:EG11292-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11292-MONOMER BioCyc MetaCyc:EG11292-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11292-MONOMER DIP DIP-36027N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36027N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M28819 http://www.ebi.ac.uk/ena/data/view/M28819 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- EchoBASE EB1269 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1269 EcoGene EG11292 http://www.ecogene.org/geneInfo.php?eg_id=EG11292 EnsemblBacteria AAC76039 http://www.ensemblgenomes.org/id/AAC76039 EnsemblBacteria AAC76039 http://www.ensemblgenomes.org/id/AAC76039 EnsemblBacteria BAE77062 http://www.ensemblgenomes.org/id/BAE77062 EnsemblBacteria BAE77062 http://www.ensemblgenomes.org/id/BAE77062 EnsemblBacteria BAE77062 http://www.ensemblgenomes.org/id/BAE77062 EnsemblBacteria b3003 http://www.ensemblgenomes.org/id/b3003 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008106 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008106 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 947478 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947478 InParanoid P0AG84 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AG84 IntAct P0AG84 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AG84* IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR002347 http://www.ebi.ac.uk/interpro/entry/IPR002347 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR020904 http://www.ebi.ac.uk/interpro/entry/IPR020904 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2972 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2972 KEGG_Gene eco:b3003 http://www.genome.jp/dbget-bin/www_bget?eco:b3003 KEGG_Orthology KO:K00540 http://www.genome.jp/dbget-bin/www_bget?KO:K00540 MINT MINT-1264908 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1264908 OMA QVNIHAM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QVNIHAM PANTHER PTHR24322 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24322 PRINTS PR00080 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00080 PRINTS PR00081 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00081 PROSITE PS00061 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00061 PSORT swissprot:YGHA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGHA_ECOLI PSORT-B swissprot:YGHA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGHA_ECOLI PSORT2 swissprot:YGHA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGHA_ECOLI Phobius swissprot:YGHA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGHA_ECOLI PhylomeDB P0AG84 http://phylomedb.org/?seqid=P0AG84 ProteinModelPortal P0AG84 http://www.proteinmodelportal.org/query/uniprot/P0AG84 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 2670903 http://www.ncbi.nlm.nih.gov/pubmed/2670903 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417476 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417476 RefSeq WP_000018760 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000018760 SMR P0AG84 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AG84 STRING 511145.b3003 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3003&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB YGHA_ECOLI http://www.uniprot.org/uniprot/YGHA_ECOLI UniProtKB-AC P0AG84 http://www.uniprot.org/uniprot/P0AG84 charge swissprot:YGHA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGHA_ECOLI eggNOG ENOG4105CYX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CYX eggNOG ENOG410XNUN http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNUN epestfind swissprot:YGHA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGHA_ECOLI garnier swissprot:YGHA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGHA_ECOLI helixturnhelix swissprot:YGHA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGHA_ECOLI hmoment swissprot:YGHA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGHA_ECOLI iep swissprot:YGHA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGHA_ECOLI inforesidue swissprot:YGHA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGHA_ECOLI octanol swissprot:YGHA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGHA_ECOLI pepcoil swissprot:YGHA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGHA_ECOLI pepdigest swissprot:YGHA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGHA_ECOLI pepinfo swissprot:YGHA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGHA_ECOLI pepnet swissprot:YGHA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGHA_ECOLI pepstats swissprot:YGHA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGHA_ECOLI pepwheel swissprot:YGHA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGHA_ECOLI pepwindow swissprot:YGHA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGHA_ECOLI sigcleave swissprot:YGHA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGHA_ECOLI ## Database ID URL or Descriptions # BRENDA 1.1.1.290 2026 # BioGrid 4259616 19 # CATALYTIC ACTIVITY 4-phospho-D-erythronate + NAD(+) = (3R)-3- hydroxy-2-oxo-4-phosphonooxybutanoate + NADH. {ECO:0000255|HAMAP- Rule MF_01825}. # CDD cd12158 ErythrP_dh # EcoGene EG10692 pdxB # FUNCTION PDXB_ECOLI Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate. {ECO 0000255|HAMAP- Rule MF_01825}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0033711 4-phosphoerythronate dehydrogenase activity; IDA:EcoCyc. # GO_function GO:0051287 NAD binding; IDA:EcoCyc. # GO_process GO:0008615 pyridoxine biosynthetic process; IDA:EcoCyc. # GO_process GO:0009070 serine family amino acid biosynthetic process; IBA:GO_Central. # GO_process GO:0042823 pyridoxal phosphate biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.720 -; 2. # HAMAP MF_01825 PdxB # INDUCTION During growth rate. {ECO:0000269|PubMed 11844765}. # IntAct P05459 9 # InterPro IPR006139 D-isomer_2_OHA_DH_cat_dom # InterPro IPR006140 D-isomer_DH_NAD-bd # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR020921 Erythronate-4-P_DHase # InterPro IPR024531 Erythronate-4-P_DHase_dimer # InterPro IPR029752 D-isomer_DH_CS1 # InterPro IPR029753 D-isomer_DH_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00750 Vitamin B6 metabolism # Organism PDXB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10996:SF111 PTHR10996:SF111 # PATHWAY PDXB_ECOLI Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4- phosphate step 2/5. {ECO 0000255|HAMAP-Rule MF_01825, ECO 0000269|PubMed 8595869}. # PATRIC 32120013 VBIEscCol129921_2416 # PIR JV0051 DEECPP # PROSITE PS00065 D_2_HYDROXYACID_DH_1 # PROSITE PS00671 D_2_HYDROXYACID_DH_3 # Pfam PF00389 2-Hacid_dh # Pfam PF02826 2-Hacid_dh_C # Pfam PF11890 DUF3410 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Erythronate-4-phosphate dehydrogenase {ECO:0000255|HAMAP-Rule MF_01825} # RefSeq NP_416823 NC_000913.3 # RefSeq WP_000699148 NZ_LN832404.1 # SIMILARITY Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily. {ECO:0000255|HAMAP- Rule MF_01825}. # SUBCELLULAR LOCATION PDXB_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_01825}. # SUBUNIT Homodimer. {ECO:0000255|HAMAP-Rule MF_01825}. # SUPFAM SSF51735 SSF51735 # UniPathway UPA00244 UER00310 # eggNOG COG0111 LUCA # eggNOG ENOG4105CJ0 Bacteria BLAST swissprot:PDXB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PDXB_ECOLI BioCyc ECOL316407:JW2317-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2317-MONOMER BioCyc EcoCyc:ERYTHRON4PDEHYDROG-MONOMER http://biocyc.org/getid?id=EcoCyc:ERYTHRON4PDEHYDROG-MONOMER BioCyc MetaCyc:ERYTHRON4PDEHYDROG-MONOMER http://biocyc.org/getid?id=MetaCyc:ERYTHRON4PDEHYDROG-MONOMER COG COG0111 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0111 DIP DIP-10449N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10449N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/nar/13.14.5297 http://dx.doi.org/10.1093/nar/13.14.5297 DOI 10.1111/j.1574-6968.1996.tb08001.x http://dx.doi.org/10.1111/j.1574-6968.1996.tb08001.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.5.1359-1369.2002 http://dx.doi.org/10.1128/JB.184.5.1359-1369.2002 EC_number EC:1.1.1.290 {ECO:0000255|HAMAP-Rule:MF_01825} http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.290 {ECO:0000255|HAMAP-Rule:MF_01825} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M15541 http://www.ebi.ac.uk/ena/data/view/M15541 EMBL M29962 http://www.ebi.ac.uk/ena/data/view/M29962 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U76961 http://www.ebi.ac.uk/ena/data/view/U76961 EMBL X02743 http://www.ebi.ac.uk/ena/data/view/X02743 ENZYME 1.1.1.290 {ECO:0000255|HAMAP-Rule:MF_01825} http://enzyme.expasy.org/EC/1.1.1.290 {ECO:0000255|HAMAP-Rule:MF_01825} EchoBASE EB0686 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0686 EcoGene EG10692 http://www.ecogene.org/geneInfo.php?eg_id=EG10692 EnsemblBacteria AAC75380 http://www.ensemblgenomes.org/id/AAC75380 EnsemblBacteria AAC75380 http://www.ensemblgenomes.org/id/AAC75380 EnsemblBacteria BAA16177 http://www.ensemblgenomes.org/id/BAA16177 EnsemblBacteria BAA16177 http://www.ensemblgenomes.org/id/BAA16177 EnsemblBacteria BAA16177 http://www.ensemblgenomes.org/id/BAA16177 EnsemblBacteria b2320 http://www.ensemblgenomes.org/id/b2320 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0033711 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033711 GO_function GO:0051287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051287 GO_process GO:0008615 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008615 GO_process GO:0009070 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009070 GO_process GO:0042823 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042823 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 946785 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946785 HAMAP MF_01825 http://hamap.expasy.org/unirule/MF_01825 HOGENOM HOG000234432 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000234432&db=HOGENOM6 InParanoid P05459 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P05459 IntAct P05459 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P05459* IntEnz 1.1.1.290 {ECO:0000255|HAMAP-Rule:MF_01825} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.290 {ECO:0000255|HAMAP-Rule:MF_01825} InterPro IPR006139 http://www.ebi.ac.uk/interpro/entry/IPR006139 InterPro IPR006140 http://www.ebi.ac.uk/interpro/entry/IPR006140 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR020921 http://www.ebi.ac.uk/interpro/entry/IPR020921 InterPro IPR024531 http://www.ebi.ac.uk/interpro/entry/IPR024531 InterPro IPR029752 http://www.ebi.ac.uk/interpro/entry/IPR029752 InterPro IPR029753 http://www.ebi.ac.uk/interpro/entry/IPR029753 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2317 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2317 KEGG_Gene eco:b2320 http://www.genome.jp/dbget-bin/www_bget?eco:b2320 KEGG_Orthology KO:K03473 http://www.genome.jp/dbget-bin/www_bget?KO:K03473 KEGG_Pathway ko00750 http://www.genome.jp/kegg-bin/show_pathway?ko00750 KEGG_Reaction rn:R04210 http://www.genome.jp/dbget-bin/www_bget?rn:R04210 OMA SAPGCNA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SAPGCNA PANTHER PTHR10996:SF111 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10996:SF111 PROSITE PS00065 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00065 PROSITE PS00671 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00671 PSORT swissprot:PDXB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PDXB_ECOLI PSORT-B swissprot:PDXB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PDXB_ECOLI PSORT2 swissprot:PDXB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PDXB_ECOLI Pfam PF00389 http://pfam.xfam.org/family/PF00389 Pfam PF02826 http://pfam.xfam.org/family/PF02826 Pfam PF11890 http://pfam.xfam.org/family/PF11890 Phobius swissprot:PDXB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PDXB_ECOLI PhylomeDB P05459 http://phylomedb.org/?seqid=P05459 ProteinModelPortal P05459 http://www.proteinmodelportal.org/query/uniprot/P05459 PubMed 11844765 http://www.ncbi.nlm.nih.gov/pubmed/11844765 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2681152 http://www.ncbi.nlm.nih.gov/pubmed/2681152 PubMed 2991861 http://www.ncbi.nlm.nih.gov/pubmed/2991861 PubMed 3029016 http://www.ncbi.nlm.nih.gov/pubmed/3029016 PubMed 8595869 http://www.ncbi.nlm.nih.gov/pubmed/8595869 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9696782 http://www.ncbi.nlm.nih.gov/pubmed/9696782 RefSeq NP_416823 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416823 RefSeq WP_000699148 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000699148 SMR P05459 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P05459 STRING 511145.b2320 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2320&targetmode=cogs STRING COG0111 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0111&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB PDXB_ECOLI http://www.uniprot.org/uniprot/PDXB_ECOLI UniProtKB-AC P05459 http://www.uniprot.org/uniprot/P05459 charge swissprot:PDXB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PDXB_ECOLI eggNOG COG0111 http://eggnogapi.embl.de/nog_data/html/tree/COG0111 eggNOG ENOG4105CJ0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CJ0 epestfind swissprot:PDXB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PDXB_ECOLI garnier swissprot:PDXB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PDXB_ECOLI helixturnhelix swissprot:PDXB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PDXB_ECOLI hmoment swissprot:PDXB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PDXB_ECOLI iep swissprot:PDXB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PDXB_ECOLI inforesidue swissprot:PDXB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PDXB_ECOLI octanol swissprot:PDXB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PDXB_ECOLI pepcoil swissprot:PDXB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PDXB_ECOLI pepdigest swissprot:PDXB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PDXB_ECOLI pepinfo swissprot:PDXB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PDXB_ECOLI pepnet swissprot:PDXB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PDXB_ECOLI pepstats swissprot:PDXB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PDXB_ECOLI pepwheel swissprot:PDXB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PDXB_ECOLI pepwindow swissprot:PDXB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PDXB_ECOLI sigcleave swissprot:PDXB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PDXB_ECOLI ## Database ID URL or Descriptions # BioGrid 4261337 8 # EcoGene EG12336 yaeH # HAMAP MF_01519 UPF0325 # InterPro IPR020911 UPF0325 # Organism YAEH_ECOLI Escherichia coli (strain K12) # PATRIC 32115435 VBIEscCol129921_0169 # PIR S45230 S45230 # Pfam PF11944 DUF3461 # ProDom PD080106 PD080106 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UPF0325 protein YaeH {ECO:0000255|HAMAP-Rule MF_01519} # RefSeq NP_414705 NC_000913.3 # RefSeq WP_000272188 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0325 family. {ECO:0000255|HAMAP- Rule MF_01519}. # eggNOG ENOG4108T8E Bacteria # eggNOG ENOG4111GD2 LUCA BLAST swissprot:YAEH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAEH_ECOLI BioCyc ECOL316407:JW0159-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0159-MONOMER BioCyc EcoCyc:EG12336-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12336-MONOMER DIP DIP-48129N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48129N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EchoBASE EB2240 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2240 EcoGene EG12336 http://www.ecogene.org/geneInfo.php?eg_id=EG12336 EnsemblBacteria AAC73274 http://www.ensemblgenomes.org/id/AAC73274 EnsemblBacteria AAC73274 http://www.ensemblgenomes.org/id/AAC73274 EnsemblBacteria BAB96740 http://www.ensemblgenomes.org/id/BAB96740 EnsemblBacteria BAB96740 http://www.ensemblgenomes.org/id/BAB96740 EnsemblBacteria BAB96740 http://www.ensemblgenomes.org/id/BAB96740 EnsemblBacteria b0163 http://www.ensemblgenomes.org/id/b0163 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947044 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947044 HAMAP MF_01519 http://hamap.expasy.org/unirule/MF_01519 HOGENOM HOG000218419 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218419&db=HOGENOM6 InterPro IPR020911 http://www.ebi.ac.uk/interpro/entry/IPR020911 KEGG_Gene ecj:JW0159 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0159 KEGG_Gene eco:b0163 http://www.genome.jp/dbget-bin/www_bget?eco:b0163 OMA NTNLRYV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NTNLRYV PSORT swissprot:YAEH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAEH_ECOLI PSORT-B swissprot:YAEH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAEH_ECOLI PSORT2 swissprot:YAEH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAEH_ECOLI Pfam PF11944 http://pfam.xfam.org/family/PF11944 Phobius swissprot:YAEH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAEH_ECOLI ProteinModelPortal P62768 http://www.proteinmodelportal.org/query/uniprot/P62768 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414705 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414705 RefSeq WP_000272188 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000272188 STRING 511145.b0163 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0163&targetmode=cogs UniProtKB YAEH_ECOLI http://www.uniprot.org/uniprot/YAEH_ECOLI UniProtKB-AC P62768 http://www.uniprot.org/uniprot/P62768 charge swissprot:YAEH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAEH_ECOLI eggNOG ENOG4108T8E http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108T8E eggNOG ENOG4111GD2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111GD2 epestfind swissprot:YAEH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAEH_ECOLI garnier swissprot:YAEH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAEH_ECOLI helixturnhelix swissprot:YAEH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAEH_ECOLI hmoment swissprot:YAEH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAEH_ECOLI iep swissprot:YAEH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAEH_ECOLI inforesidue swissprot:YAEH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAEH_ECOLI octanol swissprot:YAEH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAEH_ECOLI pepcoil swissprot:YAEH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAEH_ECOLI pepdigest swissprot:YAEH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAEH_ECOLI pepinfo swissprot:YAEH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAEH_ECOLI pepnet swissprot:YAEH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAEH_ECOLI pepstats swissprot:YAEH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAEH_ECOLI pepwheel swissprot:YAEH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAEH_ECOLI pepwindow swissprot:YAEH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAEH_ECOLI sigcleave swissprot:YAEH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAEH_ECOLI ## Database ID URL or Descriptions # BioGrid 4260921 6 # CATALYTIC ACTIVITY TALA_ECOLI Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate. # CDD cd00957 Transaldolase_TalAB # EcoGene EG11797 talA # FUNCTION TALA_ECOLI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function TALA_ECOLI GO 0004801 sedoheptulose-7-phosphate D-glyceraldehyde-3-phosphate glyceronetransferase activity; ISS UniProtKB. # GO_process GO:0005975 carbohydrate metabolic process; IEA:InterPro. # GO_process GO:0006098 pentose-phosphate shunt; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.20.20.70 -; 1. # HAMAP MF_00492 Transaldolase_1 # IntAct P0A867 10 # InterPro IPR001585 TAL/FSA # InterPro IPR004730 Transaldolase_1 # InterPro IPR013785 Aldolase_TIM # InterPro IPR018225 Transaldolase_AS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00030 Pentose phosphate pathway # Organism TALA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10683 PTHR10683 # PATHWAY Carbohydrate degradation; pentose phosphate pathway; D- glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D- ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage) step 2/3. # PATRIC 32120311 VBIEscCol129921_2558 # PIR G65021 G65021 # PROSITE PS00958 TRANSALDOLASE_2 # PROSITE PS01054 TRANSALDOLASE_1 # Pfam PF00923 TAL_FSA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TALA_ECOLI Transaldolase A # RefSeq NP_416959 NC_000913.3 # RefSeq WP_001003709 NZ_LN832404.1 # SIMILARITY Belongs to the transaldolase family. Type 1 subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION TALA_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Homodimer. {ECO 0000250}. # TIGRFAMs TIGR00874 talAB # UniPathway UPA00115 UER00414 # eggNOG COG0176 LUCA # eggNOG ENOG4105CW3 Bacteria BLAST swissprot:TALA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TALA_ECOLI BioCyc ECOL316407:JW2448-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2448-MONOMER BioCyc EcoCyc:TRANSALDOLA-MONOMER http://biocyc.org/getid?id=EcoCyc:TRANSALDOLA-MONOMER COG COG0176 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0176 DIP DIP-47872N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47872N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.2.1.2 http://www.genome.jp/dbget-bin/www_bget?EC:2.2.1.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D13159 http://www.ebi.ac.uk/ena/data/view/D13159 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.2.1.2 http://enzyme.expasy.org/EC/2.2.1.2 EchoBASE EB1745 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1745 EcoGene EG11797 http://www.ecogene.org/geneInfo.php?eg_id=EG11797 EnsemblBacteria AAC75517 http://www.ensemblgenomes.org/id/AAC75517 EnsemblBacteria AAC75517 http://www.ensemblgenomes.org/id/AAC75517 EnsemblBacteria BAA16339 http://www.ensemblgenomes.org/id/BAA16339 EnsemblBacteria BAA16339 http://www.ensemblgenomes.org/id/BAA16339 EnsemblBacteria BAA16339 http://www.ensemblgenomes.org/id/BAA16339 EnsemblBacteria b2464 http://www.ensemblgenomes.org/id/b2464 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004801 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004801 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GO_process GO:0006098 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006098 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 947006 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947006 HAMAP MF_00492 http://hamap.expasy.org/unirule/MF_00492 HOGENOM HOG000281234 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000281234&db=HOGENOM6 InParanoid P0A867 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A867 IntAct P0A867 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A867* IntEnz 2.2.1.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.2.1.2 InterPro IPR001585 http://www.ebi.ac.uk/interpro/entry/IPR001585 InterPro IPR004730 http://www.ebi.ac.uk/interpro/entry/IPR004730 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR018225 http://www.ebi.ac.uk/interpro/entry/IPR018225 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2448 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2448 KEGG_Gene eco:b2464 http://www.genome.jp/dbget-bin/www_bget?eco:b2464 KEGG_Orthology KO:K00616 http://www.genome.jp/dbget-bin/www_bget?KO:K00616 KEGG_Pathway ko00030 http://www.genome.jp/kegg-bin/show_pathway?ko00030 KEGG_Reaction rn:R01827 http://www.genome.jp/dbget-bin/www_bget?rn:R01827 OMA IRLFAID http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IRLFAID PANTHER PTHR10683 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10683 PROSITE PS00958 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00958 PROSITE PS01054 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01054 PSORT swissprot:TALA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TALA_ECOLI PSORT-B swissprot:TALA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TALA_ECOLI PSORT2 swissprot:TALA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TALA_ECOLI Pfam PF00923 http://pfam.xfam.org/family/PF00923 Phobius swissprot:TALA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TALA_ECOLI PhylomeDB P0A867 http://phylomedb.org/?seqid=P0A867 ProteinModelPortal P0A867 http://www.proteinmodelportal.org/query/uniprot/P0A867 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416959 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416959 RefSeq WP_001003709 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001003709 SMR P0A867 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A867 STRING 511145.b2464 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2464&targetmode=cogs STRING COG0176 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0176&targetmode=cogs TIGRFAMs TIGR00874 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00874 UniProtKB TALA_ECOLI http://www.uniprot.org/uniprot/TALA_ECOLI UniProtKB-AC P0A867 http://www.uniprot.org/uniprot/P0A867 charge swissprot:TALA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TALA_ECOLI eggNOG COG0176 http://eggnogapi.embl.de/nog_data/html/tree/COG0176 eggNOG ENOG4105CW3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CW3 epestfind swissprot:TALA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TALA_ECOLI garnier swissprot:TALA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TALA_ECOLI helixturnhelix swissprot:TALA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TALA_ECOLI hmoment swissprot:TALA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TALA_ECOLI iep swissprot:TALA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TALA_ECOLI inforesidue swissprot:TALA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TALA_ECOLI octanol swissprot:TALA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TALA_ECOLI pepcoil swissprot:TALA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TALA_ECOLI pepdigest swissprot:TALA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TALA_ECOLI pepinfo swissprot:TALA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TALA_ECOLI pepnet swissprot:TALA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TALA_ECOLI pepstats swissprot:TALA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TALA_ECOLI pepwheel swissprot:TALA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TALA_ECOLI pepwindow swissprot:TALA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TALA_ECOLI sigcleave swissprot:TALA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TALA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260780 7 # EcoGene EG10132 cadB # FUNCTION CADB_ECOLI Probable cadaverine/lysine antiporter or part of it. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_component GO:0016020 membrane; IDA:EcoCyc. # GO_function CADB_ECOLI GO 0015295 solute proton symporter activity; IDA EcoCyc. # GO_function CADB_ECOLI GO 0043872 lysine cadaverine antiporter activity; IMP EcoCyc. # GO_process GO:0003333 amino acid transmembrane transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0055085 transmembrane transport # INDUCTION At low pH in the presence of lysine, achieves maximal levels under anaerobic conditions. Expression controlled by CadC. {ECO:0000269|PubMed 1370290}. # IntAct P0AAE8 2 # InterPro IPR002293 AA/rel_permease1 # InterPro IPR004754 Amino_acid_antiprt # KEGG_Brite ko02000 Transporters # Organism CADB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11785 PTHR11785 # PATRIC 32123831 VBIEscCol129921_4264 # PIR A41842 A41842 # PIRSF PIRSF006060 AA_transporter # Pfam PF13520 AA_permease_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CADB_ECOLI Probable cadaverine/lysine antiporter # RefSeq NP_418556 NC_000913.3 # RefSeq WP_000092909 NZ_LN832404.1 # SIMILARITY Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family. {ECO 0000305}. # SUBCELLULAR LOCATION CADB_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # TCDB 2.A.3.2 the amino acid-polyamine-organocation (apc) family # TIGRFAMs TIGR00905 2A0302 # eggNOG COG0531 LUCA # eggNOG ENOG4105D5Q Bacteria BLAST swissprot:CADB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CADB_ECOLI BioCyc ECOL316407:JW4093-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4093-MONOMER BioCyc EcoCyc:CADB-MONOMER http://biocyc.org/getid?id=EcoCyc:CADB-MONOMER BioCyc MetaCyc:CADB-MONOMER http://biocyc.org/getid?id=MetaCyc:CADB-MONOMER COG COG0531 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0531 DIP DIP-48089N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48089N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M67452 http://www.ebi.ac.uk/ena/data/view/M67452 EMBL M76411 http://www.ebi.ac.uk/ena/data/view/M76411 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB0130 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0130 EcoGene EG10132 http://www.ecogene.org/geneInfo.php?eg_id=EG10132 EnsemblBacteria AAC77093 http://www.ensemblgenomes.org/id/AAC77093 EnsemblBacteria AAC77093 http://www.ensemblgenomes.org/id/AAC77093 EnsemblBacteria BAE78135 http://www.ensemblgenomes.org/id/BAE78135 EnsemblBacteria BAE78135 http://www.ensemblgenomes.org/id/BAE78135 EnsemblBacteria BAE78135 http://www.ensemblgenomes.org/id/BAE78135 EnsemblBacteria b4132 http://www.ensemblgenomes.org/id/b4132 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0015295 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015295 GO_function GO:0043872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043872 GO_process GO:0003333 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003333 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 948654 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948654 HOGENOM HOG000164506 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000164506&db=HOGENOM6 InParanoid P0AAE8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAE8 IntAct P0AAE8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAE8* InterPro IPR002293 http://www.ebi.ac.uk/interpro/entry/IPR002293 InterPro IPR004754 http://www.ebi.ac.uk/interpro/entry/IPR004754 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW4093 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4093 KEGG_Gene eco:b4132 http://www.genome.jp/dbget-bin/www_bget?eco:b4132 KEGG_Orthology KO:K03757 http://www.genome.jp/dbget-bin/www_bget?KO:K03757 MINT MINT-1247200 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1247200 OMA IAVACAN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IAVACAN PANTHER PTHR11785 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11785 PSORT swissprot:CADB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CADB_ECOLI PSORT-B swissprot:CADB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CADB_ECOLI PSORT2 swissprot:CADB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CADB_ECOLI Pfam PF13520 http://pfam.xfam.org/family/PF13520 Phobius swissprot:CADB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CADB_ECOLI PhylomeDB P0AAE8 http://phylomedb.org/?seqid=P0AAE8 ProteinModelPortal P0AAE8 http://www.proteinmodelportal.org/query/uniprot/P0AAE8 PubMed 1370290 http://www.ncbi.nlm.nih.gov/pubmed/1370290 PubMed 1556085 http://www.ncbi.nlm.nih.gov/pubmed/1556085 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418556 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418556 RefSeq WP_000092909 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000092909 SMR P0AAE8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAE8 STRING 511145.b4132 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4132&targetmode=cogs STRING COG0531 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0531&targetmode=cogs TCDB 2.A.3.2 http://www.tcdb.org/search/result.php?tc=2.A.3.2 TIGRFAMs TIGR00905 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00905 UniProtKB CADB_ECOLI http://www.uniprot.org/uniprot/CADB_ECOLI UniProtKB-AC P0AAE8 http://www.uniprot.org/uniprot/P0AAE8 charge swissprot:CADB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CADB_ECOLI eggNOG COG0531 http://eggnogapi.embl.de/nog_data/html/tree/COG0531 eggNOG ENOG4105D5Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D5Q epestfind swissprot:CADB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CADB_ECOLI garnier swissprot:CADB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CADB_ECOLI helixturnhelix swissprot:CADB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CADB_ECOLI hmoment swissprot:CADB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CADB_ECOLI iep swissprot:CADB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CADB_ECOLI inforesidue swissprot:CADB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CADB_ECOLI octanol swissprot:CADB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CADB_ECOLI pepcoil swissprot:CADB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CADB_ECOLI pepdigest swissprot:CADB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CADB_ECOLI pepinfo swissprot:CADB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CADB_ECOLI pepnet swissprot:CADB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CADB_ECOLI pepstats swissprot:CADB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CADB_ECOLI pepwheel swissprot:CADB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CADB_ECOLI pepwindow swissprot:CADB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CADB_ECOLI sigcleave swissprot:CADB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CADB_ECOLI ## Database ID URL or Descriptions # BioGrid 4259561 5 # EcoGene EG11495 hdeD # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0009268 response to pH; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0008150 biological_process # InterPro IPR005325 DUF308_memb # Organism HDED_ECOLI Escherichia coli (strain K12) # PATRIC 32122480 VBIEscCol129921_3618 # PIR S47731 S47731 # Pfam PF03729 DUF308; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HDED_ECOLI Protein HdeD # RefSeq NP_417968 NC_000913.3 # RefSeq WP_000965672 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA01882.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SUBCELLULAR LOCATION HDED_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 9.B.36.1 the acid resistance membrane protein (hded) family # eggNOG COG3247 LUCA # eggNOG ENOG4108YK4 Bacteria BLAST swissprot:HDED_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HDED_ECOLI BioCyc ECOL316407:JW3479-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3479-MONOMER BioCyc EcoCyc:EG11495-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11495-MONOMER DIP DIP-48170N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48170N DOI 10.1007/BF00282791 http://dx.doi.org/10.1007/BF00282791 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D11109 http://www.ebi.ac.uk/ena/data/view/D11109 EMBL D11389 http://www.ebi.ac.uk/ena/data/view/D11389 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1458 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1458 EcoGene EG11495 http://www.ecogene.org/geneInfo.php?eg_id=EG11495 EnsemblBacteria AAC76536 http://www.ensemblgenomes.org/id/AAC76536 EnsemblBacteria AAC76536 http://www.ensemblgenomes.org/id/AAC76536 EnsemblBacteria BAE77783 http://www.ensemblgenomes.org/id/BAE77783 EnsemblBacteria BAE77783 http://www.ensemblgenomes.org/id/BAE77783 EnsemblBacteria BAE77783 http://www.ensemblgenomes.org/id/BAE77783 EnsemblBacteria b3511 http://www.ensemblgenomes.org/id/b3511 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0009268 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009268 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 948024 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948024 HOGENOM HOG000125837 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125837&db=HOGENOM6 InParanoid P0AET5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AET5 IntAct P0AET5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AET5* InterPro IPR005325 http://www.ebi.ac.uk/interpro/entry/IPR005325 KEGG_Gene ecj:JW3479 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3479 KEGG_Gene eco:b3511 http://www.genome.jp/dbget-bin/www_bget?eco:b3511 MINT MINT-1261306 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1261306 OMA IGVEMIF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IGVEMIF PSORT swissprot:HDED_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HDED_ECOLI PSORT-B swissprot:HDED_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HDED_ECOLI PSORT2 swissprot:HDED_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HDED_ECOLI Pfam PF03729 http://pfam.xfam.org/family/PF03729 Phobius swissprot:HDED_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HDED_ECOLI ProteinModelPortal P0AET5 http://www.proteinmodelportal.org/query/uniprot/P0AET5 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 8244952 http://www.ncbi.nlm.nih.gov/pubmed/8244952 PubMed 8455549 http://www.ncbi.nlm.nih.gov/pubmed/8455549 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417968 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417968 RefSeq WP_000965672 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000965672 STRING 511145.b3511 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3511&targetmode=cogs TCDB 9.B.36.1 http://www.tcdb.org/search/result.php?tc=9.B.36.1 UniProtKB HDED_ECOLI http://www.uniprot.org/uniprot/HDED_ECOLI UniProtKB-AC P0AET5 http://www.uniprot.org/uniprot/P0AET5 charge swissprot:HDED_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HDED_ECOLI eggNOG COG3247 http://eggnogapi.embl.de/nog_data/html/tree/COG3247 eggNOG ENOG4108YK4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108YK4 epestfind swissprot:HDED_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HDED_ECOLI garnier swissprot:HDED_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HDED_ECOLI helixturnhelix swissprot:HDED_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HDED_ECOLI hmoment swissprot:HDED_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HDED_ECOLI iep swissprot:HDED_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HDED_ECOLI inforesidue swissprot:HDED_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HDED_ECOLI octanol swissprot:HDED_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HDED_ECOLI pepcoil swissprot:HDED_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HDED_ECOLI pepdigest swissprot:HDED_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HDED_ECOLI pepinfo swissprot:HDED_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HDED_ECOLI pepnet swissprot:HDED_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HDED_ECOLI pepstats swissprot:HDED_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HDED_ECOLI pepwheel swissprot:HDED_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HDED_ECOLI pepwindow swissprot:HDED_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HDED_ECOLI sigcleave swissprot:HDED_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HDED_ECOLI ## Database ID URL or Descriptions # BioGrid 4263300 313 # EcoGene EG11188 htrL # FUNCTION HTRL_ECOLI Involved in lipopolysaccharide biosynthesis. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IEA:UniProtKB-KW. # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # InterPro IPR011735 HtrL # Organism HTRL_ECOLI Escherichia coli (strain K12) # PATRIC 32122723 VBIEscCol129921_3738 # PIR S47839 S47839 # Pfam PF09612 HtrL_YibB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HTRL_ECOLI Protein HtrL # RefSeq NP_418075 NC_000913.3 # RefSeq WP_000842820 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA91059.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAB18595.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # TIGRFAMs TIGR02192 HtrL_YibB # eggNOG ENOG4108SEH Bacteria # eggNOG ENOG4111H5F LUCA BLAST swissprot:HTRL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HTRL_ECOLI BioCyc ECOL316407:JW5644-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5644-MONOMER BioCyc EcoCyc:EG11188-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11188-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/16.8.3586 http://dx.doi.org/10.1093/nar/16.8.3586 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M33577 http://www.ebi.ac.uk/ena/data/view/M33577 EMBL M94888 http://www.ebi.ac.uk/ena/data/view/M94888 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X06690 http://www.ebi.ac.uk/ena/data/view/X06690 EchoBASE EB1174 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1174 EcoGene EG11188 http://www.ecogene.org/geneInfo.php?eg_id=EG11188 EnsemblBacteria AAC76642 http://www.ensemblgenomes.org/id/AAC76642 EnsemblBacteria AAC76642 http://www.ensemblgenomes.org/id/AAC76642 EnsemblBacteria BAE77674 http://www.ensemblgenomes.org/id/BAE77674 EnsemblBacteria BAE77674 http://www.ensemblgenomes.org/id/BAE77674 EnsemblBacteria BAE77674 http://www.ensemblgenomes.org/id/BAE77674 EnsemblBacteria b3618 http://www.ensemblgenomes.org/id/b3618 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 948137 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948137 HOGENOM HOG000054844 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000054844&db=HOGENOM6 InParanoid P25666 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P25666 InterPro IPR011735 http://www.ebi.ac.uk/interpro/entry/IPR011735 KEGG_Gene ecj:JW5644 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5644 KEGG_Gene eco:b3618 http://www.genome.jp/dbget-bin/www_bget?eco:b3618 OMA FFDIGRG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FFDIGRG PSORT swissprot:HTRL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HTRL_ECOLI PSORT-B swissprot:HTRL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HTRL_ECOLI PSORT2 swissprot:HTRL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HTRL_ECOLI Pfam PF09612 http://pfam.xfam.org/family/PF09612 Phobius swissprot:HTRL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HTRL_ECOLI PhylomeDB P25666 http://phylomedb.org/?seqid=P25666 ProteinModelPortal P25666 http://www.proteinmodelportal.org/query/uniprot/P25666 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2198271 http://www.ncbi.nlm.nih.gov/pubmed/2198271 PubMed 3287333 http://www.ncbi.nlm.nih.gov/pubmed/3287333 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418075 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418075 RefSeq WP_000842820 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000842820 STRING 511145.b3618 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3618&targetmode=cogs TIGRFAMs TIGR02192 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02192 UniProtKB HTRL_ECOLI http://www.uniprot.org/uniprot/HTRL_ECOLI UniProtKB-AC P25666 http://www.uniprot.org/uniprot/P25666 charge swissprot:HTRL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HTRL_ECOLI eggNOG ENOG4108SEH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108SEH eggNOG ENOG4111H5F http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111H5F epestfind swissprot:HTRL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HTRL_ECOLI garnier swissprot:HTRL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HTRL_ECOLI helixturnhelix swissprot:HTRL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HTRL_ECOLI hmoment swissprot:HTRL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HTRL_ECOLI iep swissprot:HTRL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HTRL_ECOLI inforesidue swissprot:HTRL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HTRL_ECOLI octanol swissprot:HTRL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HTRL_ECOLI pepcoil swissprot:HTRL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HTRL_ECOLI pepdigest swissprot:HTRL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HTRL_ECOLI pepinfo swissprot:HTRL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HTRL_ECOLI pepnet swissprot:HTRL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HTRL_ECOLI pepstats swissprot:HTRL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HTRL_ECOLI pepwheel swissprot:HTRL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HTRL_ECOLI pepwindow swissprot:HTRL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HTRL_ECOLI sigcleave swissprot:HTRL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HTRL_ECOLI ## Database ID URL or Descriptions # BioGrid 4262952 6 # EcoGene EG11953 mdtO # FUNCTION MDTO_ECOLI Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015546 sulfathiazole transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0015906 sulfathiazole transport; IMP:EcoCyc. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # INDUCTION Induced by LeuO, part of the mdtNO operon. {ECO:0000269|PubMed 19429622}. # INTERACTION MDTO_ECOLI P07395 pheT; NbExp=3; IntAct=EBI-555775, EBI-555713; P76237 yeaJ; NbExp=2; IntAct=EBI-555775, EBI-555763; # IntAct P32715 3 # InterPro IPR006726 PHBA_efflux_AaeB/fusaric-R # KEGG_Brite ko02000 Transporters # Organism MDTO_ECOLI Escherichia coli (strain K12) # PATRIC 32123715 VBIEscCol129921_4206 # PIR H65216 H65216 # Pfam PF04632 FUSC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MDTO_ECOLI Multidrug resistance protein MdtO # RefSeq NP_418505 NC_000913.3 # RefSeq WP_001275207 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAC43175.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the MdtO family. {ECO 0000305}. # SUBCELLULAR LOCATION MDTO_ECOLI Cell inner membrane {ECO 0000305|PubMed 15919996}; Multi-pass membrane protein {ECO 0000305|PubMed 15919996}. # SUBUNIT MDTO_ECOLI Could be part of a tripartite efflux system composed of MdtN, MdtO and MdtP. # TCDB 2.A.85.6 the aromatic acid exporter (arae) family # eggNOG COG1289 LUCA # eggNOG ENOG4108MI0 Bacteria BLAST swissprot:MDTO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MDTO_ECOLI BioCyc ECOL316407:JW4042-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4042-MONOMER BioCyc EcoCyc:YJCQ-MONOMER http://biocyc.org/getid?id=EcoCyc:YJCQ-MONOMER COG COG1289 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1289 DIP DIP-12556N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12556N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AAC.45.4.1126-1136.2001 http://dx.doi.org/10.1128/AAC.45.4.1126-1136.2001 DOI 10.1128/JB.00108-09 http://dx.doi.org/10.1128/JB.00108-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1896 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1896 EcoGene EG11953 http://www.ecogene.org/geneInfo.php?eg_id=EG11953 EnsemblBacteria AAD13464 http://www.ensemblgenomes.org/id/AAD13464 EnsemblBacteria AAD13464 http://www.ensemblgenomes.org/id/AAD13464 EnsemblBacteria BAE78083 http://www.ensemblgenomes.org/id/BAE78083 EnsemblBacteria BAE78083 http://www.ensemblgenomes.org/id/BAE78083 EnsemblBacteria BAE78083 http://www.ensemblgenomes.org/id/BAE78083 EnsemblBacteria b4081 http://www.ensemblgenomes.org/id/b4081 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015546 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015546 GO_process GO:0015906 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015906 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 948582 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948582 HOGENOM HOG000126953 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126953&db=HOGENOM6 IntAct P32715 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32715* InterPro IPR006726 http://www.ebi.ac.uk/interpro/entry/IPR006726 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW4042 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4042 KEGG_Gene eco:b4081 http://www.genome.jp/dbget-bin/www_bget?eco:b4081 KEGG_Orthology KO:K15547 http://www.genome.jp/dbget-bin/www_bget?KO:K15547 MINT MINT-1312912 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1312912 OMA QSDWRIT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QSDWRIT PSORT swissprot:MDTO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MDTO_ECOLI PSORT-B swissprot:MDTO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MDTO_ECOLI PSORT2 swissprot:MDTO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MDTO_ECOLI Pfam PF04632 http://pfam.xfam.org/family/PF04632 Phobius swissprot:MDTO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MDTO_ECOLI ProteinModelPortal P32715 http://www.proteinmodelportal.org/query/uniprot/P32715 PubMed 11257026 http://www.ncbi.nlm.nih.gov/pubmed/11257026 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19429622 http://www.ncbi.nlm.nih.gov/pubmed/19429622 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418505 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418505 RefSeq WP_001275207 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001275207 STRING 511145.b4081 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4081&targetmode=cogs STRING COG1289 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1289&targetmode=cogs TCDB 2.A.85.6 http://www.tcdb.org/search/result.php?tc=2.A.85.6 UniProtKB MDTO_ECOLI http://www.uniprot.org/uniprot/MDTO_ECOLI UniProtKB-AC P32715 http://www.uniprot.org/uniprot/P32715 charge swissprot:MDTO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MDTO_ECOLI eggNOG COG1289 http://eggnogapi.embl.de/nog_data/html/tree/COG1289 eggNOG ENOG4108MI0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MI0 epestfind swissprot:MDTO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MDTO_ECOLI garnier swissprot:MDTO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MDTO_ECOLI helixturnhelix swissprot:MDTO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MDTO_ECOLI hmoment swissprot:MDTO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MDTO_ECOLI iep swissprot:MDTO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MDTO_ECOLI inforesidue swissprot:MDTO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MDTO_ECOLI octanol swissprot:MDTO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MDTO_ECOLI pepcoil swissprot:MDTO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MDTO_ECOLI pepdigest swissprot:MDTO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MDTO_ECOLI pepinfo swissprot:MDTO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MDTO_ECOLI pepnet swissprot:MDTO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MDTO_ECOLI pepstats swissprot:MDTO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MDTO_ECOLI pepwheel swissprot:MDTO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MDTO_ECOLI pepwindow swissprot:MDTO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MDTO_ECOLI sigcleave swissprot:MDTO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MDTO_ECOLI ## Database ID URL or Descriptions # AltName RZOR_ECOLI Outer membrane lipoprotein Rz1 from lambdoid prophage Rac # AltName RZOR_ECOLI Spanin from lambdoid prophage Rac, outer membrane subunit # BioGrid 4260160 14 # EcoGene EG14381 rzoR # FUNCTION RZOR_ECOLI Component of the spanin complex that disrupts the outer membrane and causes cell lysis during virus exit. The spanin complex conducts the final step in cell lysis by disrupting the outer membrane after holin and endolysin action have permeabilized the inner membrane and degraded the host peptidoglycans (By similarity). {ECO 0000250}. # GO_component GO:0009279 cell outer membrane; IEA:UniProtKB-SubCell. # GO_process GO:0019076 viral release from host cell; IEA:UniProtKB-KW. # GO_process GO:0019835 cytolysis; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0008150 biological_process # GOslim_process GO:0040011 locomotion # GOslim_process GO:0044403 symbiosis, encompassing mutualism through parasitism # InterPro IPR010346 o-spanin # Organism RZOR_ECOLI Escherichia coli (strain K12) # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF06085 Rz1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Prophage outer membrane lipoprotein RzoR {ECO 0000305} # RefSeq YP_588452 NC_000913.3 # SIMILARITY Belongs to the lambdalikevirus o-spanin family. {ECO 0000305}. # SUBCELLULAR LOCATION RZOR_ECOLI Cell outer membrane {ECO 0000250}; Lipid- anchor {ECO 0000255|PROSITE-ProRule PRU00303}; Periplasmic side {ECO 0000250}. # SUBUNIT Homodimer; disulfide-linked. Interacts (via C-terminus) with RZ (via C-terminus). Part of the spanin complex which spans the entire periplasmic space. The spanin complex is composed of spanin, inner membrane subunit and spanin, outer membrane subunit (By similarity). {ECO 0000250}. BLAST swissprot:RZOR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RZOR_ECOLI BioCyc ECOL316407:JW5213-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5213-MONOMER BioCyc EcoCyc:MONOMER0-2671 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2671 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14381 http://www.ecogene.org/geneInfo.php?eg_id=EG14381 EnsemblBacteria ABD18660 http://www.ensemblgenomes.org/id/ABD18660 EnsemblBacteria ABD18660 http://www.ensemblgenomes.org/id/ABD18660 EnsemblBacteria BAE76416 http://www.ensemblgenomes.org/id/BAE76416 EnsemblBacteria BAE76416 http://www.ensemblgenomes.org/id/BAE76416 EnsemblBacteria BAE76416 http://www.ensemblgenomes.org/id/BAE76416 EnsemblBacteria b4528 http://www.ensemblgenomes.org/id/b4528 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_process GO:0019076 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019076 GO_process GO:0019835 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019835 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0040011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011 GOslim_process GO:0044403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403 GeneID 1450262 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1450262 HOGENOM HOG000054872 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000054872&db=HOGENOM6 InterPro IPR010346 http://www.ebi.ac.uk/interpro/entry/IPR010346 KEGG_Gene ecj:JW5213 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5213 KEGG_Gene eco:b4528 http://www.genome.jp/dbget-bin/www_bget?eco:b4528 OMA KLKMMFC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KLKMMFC PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:RZOR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RZOR_ECOLI PSORT-B swissprot:RZOR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RZOR_ECOLI PSORT2 swissprot:RZOR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RZOR_ECOLI Pfam PF06085 http://pfam.xfam.org/family/PF06085 Phobius swissprot:RZOR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RZOR_ECOLI ProteinModelPortal P58042 http://www.proteinmodelportal.org/query/uniprot/P58042 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq YP_588452 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_588452 STRING 511145.b4528 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4528&targetmode=cogs UniProtKB RZOR_ECOLI http://www.uniprot.org/uniprot/RZOR_ECOLI UniProtKB-AC P58042 http://www.uniprot.org/uniprot/P58042 charge swissprot:RZOR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RZOR_ECOLI epestfind swissprot:RZOR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RZOR_ECOLI garnier swissprot:RZOR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RZOR_ECOLI helixturnhelix swissprot:RZOR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RZOR_ECOLI hmoment swissprot:RZOR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RZOR_ECOLI iep swissprot:RZOR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RZOR_ECOLI inforesidue swissprot:RZOR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RZOR_ECOLI octanol swissprot:RZOR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RZOR_ECOLI pepcoil swissprot:RZOR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RZOR_ECOLI pepdigest swissprot:RZOR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RZOR_ECOLI pepinfo swissprot:RZOR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RZOR_ECOLI pepnet swissprot:RZOR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RZOR_ECOLI pepstats swissprot:RZOR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RZOR_ECOLI pepwheel swissprot:RZOR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RZOR_ECOLI pepwindow swissprot:RZOR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RZOR_ECOLI sigcleave swissprot:RZOR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RZOR_ECOLI ## Database ID URL or Descriptions # BioGrid 4261832 81 # EcoGene EG13672 ybhP # Gene3D 3.60.10.10 -; 1. # IntAct P0AAW1 2 # InterPro IPR005135 Endo/exonuclease/phosphatase # Organism YBHP_ECOLI Escherichia coli (strain K12) # PATRIC 32116781 VBIEscCol129921_0816 # PIR F64815 F64815 # Pfam PF03372 Exo_endo_phos # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBHP_ECOLI Uncharacterized protein YbhP # RefSeq NP_415311 NC_000913.3 # RefSeq WP_001113348 NZ_LN832404.1 # SUPFAM SSF56219 SSF56219 # eggNOG COG3568 LUCA # eggNOG ENOG4105X23 Bacteria BLAST swissprot:YBHP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBHP_ECOLI BioCyc ECOL316407:JW0773-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0773-MONOMER BioCyc EcoCyc:G6407-MONOMER http://biocyc.org/getid?id=EcoCyc:G6407-MONOMER COG COG3568 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3568 DIP DIP-48150N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48150N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3436 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3436 EcoGene EG13672 http://www.ecogene.org/geneInfo.php?eg_id=EG13672 EnsemblBacteria AAC73877 http://www.ensemblgenomes.org/id/AAC73877 EnsemblBacteria AAC73877 http://www.ensemblgenomes.org/id/AAC73877 EnsemblBacteria BAA35449 http://www.ensemblgenomes.org/id/BAA35449 EnsemblBacteria BAA35449 http://www.ensemblgenomes.org/id/BAA35449 EnsemblBacteria BAA35449 http://www.ensemblgenomes.org/id/BAA35449 EnsemblBacteria b0790 http://www.ensemblgenomes.org/id/b0790 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.60.10.10 http://www.cathdb.info/version/latest/superfamily/3.60.10.10 GeneID 945408 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945408 HOGENOM HOG000261042 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261042&db=HOGENOM6 InParanoid P0AAW1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAW1 IntAct P0AAW1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAW1* InterPro IPR005135 http://www.ebi.ac.uk/interpro/entry/IPR005135 KEGG_Gene ecj:JW0773 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0773 KEGG_Gene eco:b0790 http://www.genome.jp/dbget-bin/www_bget?eco:b0790 KEGG_Orthology KO:K06896 http://www.genome.jp/dbget-bin/www_bget?KO:K06896 OMA KPARSFP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KPARSFP PSORT swissprot:YBHP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBHP_ECOLI PSORT-B swissprot:YBHP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBHP_ECOLI PSORT2 swissprot:YBHP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBHP_ECOLI Pfam PF03372 http://pfam.xfam.org/family/PF03372 Phobius swissprot:YBHP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBHP_ECOLI PhylomeDB P0AAW1 http://phylomedb.org/?seqid=P0AAW1 ProteinModelPortal P0AAW1 http://www.proteinmodelportal.org/query/uniprot/P0AAW1 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415311 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415311 RefSeq WP_001113348 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001113348 STRING 511145.b0790 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0790&targetmode=cogs STRING COG3568 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3568&targetmode=cogs SUPFAM SSF56219 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56219 UniProtKB YBHP_ECOLI http://www.uniprot.org/uniprot/YBHP_ECOLI UniProtKB-AC P0AAW1 http://www.uniprot.org/uniprot/P0AAW1 charge swissprot:YBHP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBHP_ECOLI eggNOG COG3568 http://eggnogapi.embl.de/nog_data/html/tree/COG3568 eggNOG ENOG4105X23 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105X23 epestfind swissprot:YBHP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBHP_ECOLI garnier swissprot:YBHP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBHP_ECOLI helixturnhelix swissprot:YBHP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBHP_ECOLI hmoment swissprot:YBHP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBHP_ECOLI iep swissprot:YBHP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBHP_ECOLI inforesidue swissprot:YBHP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBHP_ECOLI octanol swissprot:YBHP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBHP_ECOLI pepcoil swissprot:YBHP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBHP_ECOLI pepdigest swissprot:YBHP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBHP_ECOLI pepinfo swissprot:YBHP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBHP_ECOLI pepnet swissprot:YBHP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBHP_ECOLI pepstats swissprot:YBHP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBHP_ECOLI pepwheel swissprot:YBHP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBHP_ECOLI pepwindow swissprot:YBHP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBHP_ECOLI sigcleave swissprot:YBHP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBHP_ECOLI ## Database ID URL or Descriptions # AltName SSUE_ECOLI FMN reductase # AltName SSUE_ECOLI Sulfate starvation-induced protein 4 # BRENDA 1.5.1.38 2026 # BioGrid 4262118 25 # CATALYTIC ACTIVITY SSUE_ECOLI FMNH(2) + NADP(+) = FMN + NADPH. # EcoGene EG13708 ssuE # FUNCTION SSUE_ECOLI Catalyzes an NADPH-dependent reduction of FMN, but is also able to reduce FAD or riboflavin. # GO_function GO:0008752 FMN reductase activity; IDA:EcoCyc. # GO_function GO:0052873 FMN reductase (NADPH) activity; IEA:UniProtKB-EC. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0009970 cellular response to sulfate starvation; IEP:EcoCyc. # GO_process GO:0046306 alkanesulfonate catabolic process; IMP:EcoCyc. # GO_process GO:0051289 protein homotetramerization; IDA:EcoCyc. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009056 catabolic process # Gene3D 3.40.50.360 -; 1. # INDUCTION SSUE_ECOLI Repressed by sulfate or cysteine. # INTERACTION SSUE_ECOLI P80645 ssuD; NbExp=2; IntAct=EBI-1121047, EBI-561637; # IntAct P80644 5 # InterPro IPR005025 FMN_Rdtase-like # InterPro IPR020048 NADPH-dep_FMN_reduc_SsuE # InterPro IPR029039 Flavoprotein-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00740 Riboflavin metabolism # Organism SSUE_ECOLI Escherichia coli (strain K12) # PATRIC 32117093 VBIEscCol129921_0971 # PDB 4PTY X-ray; 2.10 A; A/B/C/D=1-191 # PDB 4PTZ X-ray; 1.90 A; A/B/C/D=1-191 # PDB 4PU0 X-ray; 2.30 A; A/B/C/D=1-191 # PIR H64833 H64833 # Pfam PF03358 FMN_red # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SSUE_ECOLI FMN reductase (NADPH) # RefSeq NP_415457 NC_000913.3 # RefSeq WP_001263933 NZ_LN832404.1 # SIMILARITY Belongs to the SsuE family. {ECO 0000305}. # SUBUNIT SSUE_ECOLI Homodimer. # SUPFAM SSF52218 SSF52218 # TIGRFAMs TIGR03567 FMN_reduc_SsuE # eggNOG COG0431 LUCA # eggNOG ENOG4108UZX Bacteria BLAST swissprot:SSUE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SSUE_ECOLI BioCyc ECOL316407:JW0920-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0920-MONOMER BioCyc EcoCyc:MONOMER0-146 http://biocyc.org/getid?id=EcoCyc:MONOMER0-146 BioCyc MetaCyc:MONOMER0-146 http://biocyc.org/getid?id=MetaCyc:MONOMER0-146 COG COG0431 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0431 DIP DIP-10929N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10929N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.274.38.26639 http://dx.doi.org/10.1074/jbc.274.38.26639 DOI 10.1074/jbc.274.41.29358 http://dx.doi.org/10.1074/jbc.274.41.29358 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1432-1033.1996.0773u.x http://dx.doi.org/10.1111/j.1432-1033.1996.0773u.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.5.1.38 http://www.genome.jp/dbget-bin/www_bget?EC:1.5.1.38 EMBL AJ237695 http://www.ebi.ac.uk/ena/data/view/AJ237695 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.5.1.38 http://enzyme.expasy.org/EC/1.5.1.38 EchoBASE EB3472 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3472 EcoGene EG13708 http://www.ecogene.org/geneInfo.php?eg_id=EG13708 EnsemblBacteria AAC74023 http://www.ensemblgenomes.org/id/AAC74023 EnsemblBacteria AAC74023 http://www.ensemblgenomes.org/id/AAC74023 EnsemblBacteria BAA35692 http://www.ensemblgenomes.org/id/BAA35692 EnsemblBacteria BAA35692 http://www.ensemblgenomes.org/id/BAA35692 EnsemblBacteria BAA35692 http://www.ensemblgenomes.org/id/BAA35692 EnsemblBacteria b0937 http://www.ensemblgenomes.org/id/b0937 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008752 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008752 GO_function GO:0052873 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052873 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0009970 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009970 GO_process GO:0046306 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046306 GO_process GO:0051289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051289 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 3.40.50.360 http://www.cathdb.info/version/latest/superfamily/3.40.50.360 GeneID 945947 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945947 HOGENOM HOG000263120 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000263120&db=HOGENOM6 InParanoid P80644 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P80644 IntAct P80644 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P80644* IntEnz 1.5.1.38 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.5.1.38 InterPro IPR005025 http://www.ebi.ac.uk/interpro/entry/IPR005025 InterPro IPR020048 http://www.ebi.ac.uk/interpro/entry/IPR020048 InterPro IPR029039 http://www.ebi.ac.uk/interpro/entry/IPR029039 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0920 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0920 KEGG_Gene eco:b0937 http://www.genome.jp/dbget-bin/www_bget?eco:b0937 KEGG_Orthology KO:K00299 http://www.genome.jp/dbget-bin/www_bget?KO:K00299 KEGG_Pathway ko00740 http://www.genome.jp/kegg-bin/show_pathway?ko00740 KEGG_Reaction rn:R05706 http://www.genome.jp/dbget-bin/www_bget?rn:R05706 OMA ARFDSPQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ARFDSPQ PDB 4PTY http://www.ebi.ac.uk/pdbe-srv/view/entry/4PTY PDB 4PTZ http://www.ebi.ac.uk/pdbe-srv/view/entry/4PTZ PDB 4PU0 http://www.ebi.ac.uk/pdbe-srv/view/entry/4PU0 PDBsum 4PTY http://www.ebi.ac.uk/pdbsum/4PTY PDBsum 4PTZ http://www.ebi.ac.uk/pdbsum/4PTZ PDBsum 4PU0 http://www.ebi.ac.uk/pdbsum/4PU0 PSORT swissprot:SSUE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SSUE_ECOLI PSORT-B swissprot:SSUE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SSUE_ECOLI PSORT2 swissprot:SSUE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SSUE_ECOLI Pfam PF03358 http://pfam.xfam.org/family/PF03358 Phobius swissprot:SSUE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SSUE_ECOLI PhylomeDB P80644 http://phylomedb.org/?seqid=P80644 ProteinModelPortal P80644 http://www.proteinmodelportal.org/query/uniprot/P80644 PubMed 10480865 http://www.ncbi.nlm.nih.gov/pubmed/10480865 PubMed 10506196 http://www.ncbi.nlm.nih.gov/pubmed/10506196 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8774726 http://www.ncbi.nlm.nih.gov/pubmed/8774726 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415457 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415457 RefSeq WP_001263933 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001263933 SMR P80644 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P80644 STRING 511145.b0937 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0937&targetmode=cogs STRING COG0431 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0431&targetmode=cogs SUPFAM SSF52218 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52218 TIGRFAMs TIGR03567 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03567 UniProtKB SSUE_ECOLI http://www.uniprot.org/uniprot/SSUE_ECOLI UniProtKB-AC P80644 http://www.uniprot.org/uniprot/P80644 charge swissprot:SSUE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SSUE_ECOLI eggNOG COG0431 http://eggnogapi.embl.de/nog_data/html/tree/COG0431 eggNOG ENOG4108UZX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UZX epestfind swissprot:SSUE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SSUE_ECOLI garnier swissprot:SSUE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SSUE_ECOLI helixturnhelix swissprot:SSUE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SSUE_ECOLI hmoment swissprot:SSUE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SSUE_ECOLI iep swissprot:SSUE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SSUE_ECOLI inforesidue swissprot:SSUE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SSUE_ECOLI octanol swissprot:SSUE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SSUE_ECOLI pepcoil swissprot:SSUE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SSUE_ECOLI pepdigest swissprot:SSUE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SSUE_ECOLI pepinfo swissprot:SSUE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SSUE_ECOLI pepnet swissprot:SSUE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SSUE_ECOLI pepstats swissprot:SSUE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SSUE_ECOLI pepwheel swissprot:SSUE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SSUE_ECOLI pepwindow swissprot:SSUE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SSUE_ECOLI sigcleave swissprot:SSUE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SSUE_ECOLI ## Database ID URL or Descriptions # BioGrid 4263003 184 # CDD cd06261 TM_PBP2 # EcoGene EG20256 sapC # FUNCTION SAPC_ECOLI Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0022857 transmembrane transporter activity; IBA:GO_Central. # GO_process GO:0015031 protein transport; IEA:UniProtKB-KW. # GO_process GO:0015833 peptide transport; IEA:UniProtKB-KW. # GO_process GO:0055085 transmembrane transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # Gene3D 1.10.3720.10 -; 1. # InterPro IPR000515 MetI-like # InterPro IPR025966 OppC_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00324 Dipeptide transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism SAPC_ECOLI Escherichia coli (strain K12) # PATRIC 32117854 VBIEscCol129921_1347 # PIR G64877 G64877 # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Pfam PF12911 OppC_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SAPC_ECOLI Peptide transport system permease protein SapC # RefSeq NP_415808 NC_000913.3 # RefSeq WP_001146163 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION SAPC_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF161098 SSF161098 # TCDB 3.A.1.5.42 the atp-binding cassette (abc) superfamily # eggNOG COG4171 LUCA # eggNOG ENOG4108EU3 Bacteria BLAST swissprot:SAPC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SAPC_ECOLI BioCyc ECOL316407:JW1285-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1285-MONOMER BioCyc EcoCyc:SAPC-MONOMER http://biocyc.org/getid?id=EcoCyc:SAPC-MONOMER COG COG1173 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1173 DIP DIP-10824N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10824N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X97282 http://www.ebi.ac.uk/ena/data/view/X97282 EchoBASE EB4157 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4157 EcoGene EG20256 http://www.ecogene.org/geneInfo.php?eg_id=EG20256 EnsemblBacteria AAC74374 http://www.ensemblgenomes.org/id/AAC74374 EnsemblBacteria AAC74374 http://www.ensemblgenomes.org/id/AAC74374 EnsemblBacteria BAA14845 http://www.ensemblgenomes.org/id/BAA14845 EnsemblBacteria BAA14845 http://www.ensemblgenomes.org/id/BAA14845 EnsemblBacteria BAA14845 http://www.ensemblgenomes.org/id/BAA14845 EnsemblBacteria b1292 http://www.ensemblgenomes.org/id/b1292 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GO_process GO:0015031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031 GO_process GO:0015833 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015833 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 945266 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945266 HOGENOM HOG000171368 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000171368&db=HOGENOM6 InParanoid P0AGH5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGH5 IntAct P0AGH5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AGH5* InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 InterPro IPR025966 http://www.ebi.ac.uk/interpro/entry/IPR025966 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1285 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1285 KEGG_Gene eco:b1292 http://www.genome.jp/dbget-bin/www_bget?eco:b1292 KEGG_Orthology KO:K12370 http://www.genome.jp/dbget-bin/www_bget?KO:K12370 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 MINT MINT-1289680 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1289680 OMA FGSWFAP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FGSWFAP PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:SAPC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SAPC_ECOLI PSORT-B swissprot:SAPC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SAPC_ECOLI PSORT2 swissprot:SAPC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SAPC_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Pfam PF12911 http://pfam.xfam.org/family/PF12911 Phobius swissprot:SAPC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SAPC_ECOLI PhylomeDB P0AGH5 http://phylomedb.org/?seqid=P0AGH5 ProteinModelPortal P0AGH5 http://www.proteinmodelportal.org/query/uniprot/P0AGH5 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415808 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415808 RefSeq WP_001146163 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001146163 SMR P0AGH5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AGH5 STRING 511145.b1292 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1292&targetmode=cogs STRING COG1173 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1173&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.5.42 http://www.tcdb.org/search/result.php?tc=3.A.1.5.42 UniProtKB SAPC_ECOLI http://www.uniprot.org/uniprot/SAPC_ECOLI UniProtKB-AC P0AGH5 http://www.uniprot.org/uniprot/P0AGH5 charge swissprot:SAPC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SAPC_ECOLI eggNOG COG4171 http://eggnogapi.embl.de/nog_data/html/tree/COG4171 eggNOG ENOG4108EU3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108EU3 epestfind swissprot:SAPC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SAPC_ECOLI garnier swissprot:SAPC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SAPC_ECOLI helixturnhelix swissprot:SAPC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SAPC_ECOLI hmoment swissprot:SAPC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SAPC_ECOLI iep swissprot:SAPC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SAPC_ECOLI inforesidue swissprot:SAPC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SAPC_ECOLI octanol swissprot:SAPC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SAPC_ECOLI pepcoil swissprot:SAPC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SAPC_ECOLI pepdigest swissprot:SAPC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SAPC_ECOLI pepinfo swissprot:SAPC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SAPC_ECOLI pepnet swissprot:SAPC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SAPC_ECOLI pepstats swissprot:SAPC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SAPC_ECOLI pepwheel swissprot:SAPC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SAPC_ECOLI pepwindow swissprot:SAPC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SAPC_ECOLI sigcleave swissprot:SAPC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SAPC_ECOLI ## Database ID URL or Descriptions # BioGrid 4261576 29 # CATALYTIC ACTIVITY HCAF_ECOLI (2E)-3-phenylprop-2-enoate + NADH + O(2) = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + NAD(+). # CATALYTIC ACTIVITY HCAF_ECOLI 3-phenylpropanoate + NADH + O(2) = 3-(cis-5,6- dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+). # CDD cd00667 ring_hydroxylating_dioxygenase # EcoGene EG13457 hcaF # FUNCTION HCAF_ECOLI Part of the multicomponent 3-phenylpropionate dioxygenase. Converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol), respectively. {ECO 0000269|PubMed 9603882}. # GO_function GO:0008695 3-phenylpropionate dioxygenase activity; IEA:UniProtKB-HAMAP. # GO_process GO:0019380 3-phenylpropionate catabolic process; IMP:EcoCyc. # GO_process GO:0019439 aromatic compound catabolic process; IEA:UniProtKB-HAMAP. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.10.450.50 -; 1. # HAMAP MF_01649 HcaF # InterPro IPR000391 Rng_hydr_dOase-bsu # InterPro IPR023712 HcaF # InterPro IPR032710 NTF2-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00360 Phenylalanine metabolism # Organism HCAF_ECOLI Escherichia coli (strain K12) # PATHWAY HCAF_ECOLI Aromatic compound metabolism; 3-phenylpropanoate degradation. # PATRIC 32120475 VBIEscCol129921_2640 # PIR B65031 B65031 # Pfam PF00866 Ring_hydroxyl_B # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HCAF_ECOLI 3-phenylpropionate/cinnamic acid dioxygenase subunit beta # RefSeq NP_417034 NC_000913.3 # RefSeq WP_001276072 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial ring-hydroxylating dioxygenase beta subunit family. {ECO 0000305}. # SUBUNIT This dioxygenase system consists of four proteins the two subunits of the hydroxylase component (HcaE and HcaF), a ferredoxin (HcaC) and a ferredoxin reductase (HcaD). # SUPFAM SSF54427 SSF54427 # eggNOG COG5517 LUCA # eggNOG ENOG4108SBK Bacteria BLAST swissprot:HCAF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HCAF_ECOLI BioCyc ECOL316407:JW2523-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2523-MONOMER BioCyc EcoCyc:HCAA2-MONOMER http://biocyc.org/getid?id=EcoCyc:HCAA2-MONOMER BioCyc MetaCyc:HCAA2-MONOMER http://biocyc.org/getid?id=MetaCyc:HCAA2-MONOMER COG COG5517 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG5517 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.14.12.19 http://www.genome.jp/dbget-bin/www_bget?EC:1.14.12.19 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL Y11070 http://www.ebi.ac.uk/ena/data/view/Y11070 EMBL Z37966 http://www.ebi.ac.uk/ena/data/view/Z37966 ENZYME 1.14.12.19 http://enzyme.expasy.org/EC/1.14.12.19 EchoBASE EB3230 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3230 EcoGene EG13457 http://www.ecogene.org/geneInfo.php?eg_id=EG13457 EnsemblBacteria AAC75592 http://www.ensemblgenomes.org/id/AAC75592 EnsemblBacteria AAC75592 http://www.ensemblgenomes.org/id/AAC75592 EnsemblBacteria BAA16442 http://www.ensemblgenomes.org/id/BAA16442 EnsemblBacteria BAA16442 http://www.ensemblgenomes.org/id/BAA16442 EnsemblBacteria BAA16442 http://www.ensemblgenomes.org/id/BAA16442 EnsemblBacteria b2539 http://www.ensemblgenomes.org/id/b2539 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008695 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008695 GO_process GO:0019380 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019380 GO_process GO:0019439 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019439 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.10.450.50 http://www.cathdb.info/version/latest/superfamily/3.10.450.50 GeneID 946997 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946997 HAMAP MF_01649 http://hamap.expasy.org/unirule/MF_01649 HOGENOM HOG000106036 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000106036&db=HOGENOM6 InParanoid Q47140 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q47140 IntEnz 1.14.12.19 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.14.12.19 InterPro IPR000391 http://www.ebi.ac.uk/interpro/entry/IPR000391 InterPro IPR023712 http://www.ebi.ac.uk/interpro/entry/IPR023712 InterPro IPR032710 http://www.ebi.ac.uk/interpro/entry/IPR032710 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2523 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2523 KEGG_Gene eco:b2539 http://www.genome.jp/dbget-bin/www_bget?eco:b2539 KEGG_Orthology KO:K05709 http://www.genome.jp/dbget-bin/www_bget?KO:K05709 KEGG_Pathway ko00360 http://www.genome.jp/kegg-bin/show_pathway?ko00360 KEGG_Reaction rn:R06782 http://www.genome.jp/dbget-bin/www_bget?rn:R06782 KEGG_Reaction rn:R06783 http://www.genome.jp/dbget-bin/www_bget?rn:R06783 OMA QRHFISN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QRHFISN PSORT swissprot:HCAF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HCAF_ECOLI PSORT-B swissprot:HCAF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HCAF_ECOLI PSORT2 swissprot:HCAF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HCAF_ECOLI Pfam PF00866 http://pfam.xfam.org/family/PF00866 Phobius swissprot:HCAF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HCAF_ECOLI ProteinModelPortal Q47140 http://www.proteinmodelportal.org/query/uniprot/Q47140 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9603882 http://www.ncbi.nlm.nih.gov/pubmed/9603882 RefSeq NP_417034 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417034 RefSeq WP_001276072 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001276072 SMR Q47140 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q47140 STRING 511145.b2539 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2539&targetmode=cogs STRING COG5517 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG5517&targetmode=cogs SUPFAM SSF54427 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54427 UniProtKB HCAF_ECOLI http://www.uniprot.org/uniprot/HCAF_ECOLI UniProtKB-AC Q47140 http://www.uniprot.org/uniprot/Q47140 charge swissprot:HCAF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HCAF_ECOLI eggNOG COG5517 http://eggnogapi.embl.de/nog_data/html/tree/COG5517 eggNOG ENOG4108SBK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108SBK epestfind swissprot:HCAF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HCAF_ECOLI garnier swissprot:HCAF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HCAF_ECOLI helixturnhelix swissprot:HCAF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HCAF_ECOLI hmoment swissprot:HCAF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HCAF_ECOLI iep swissprot:HCAF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HCAF_ECOLI inforesidue swissprot:HCAF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HCAF_ECOLI octanol swissprot:HCAF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HCAF_ECOLI pepcoil swissprot:HCAF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HCAF_ECOLI pepdigest swissprot:HCAF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HCAF_ECOLI pepinfo swissprot:HCAF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HCAF_ECOLI pepnet swissprot:HCAF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HCAF_ECOLI pepstats swissprot:HCAF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HCAF_ECOLI pepwheel swissprot:HCAF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HCAF_ECOLI pepwindow swissprot:HCAF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HCAF_ECOLI sigcleave swissprot:HCAF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HCAF_ECOLI ## Database ID URL or Descriptions # AltName QUEC_ECOLI 7-cyano-7-carbaguanine synthase # AltName QUEC_ECOLI PreQ(0) synthase # AltName QUEC_ECOLI Queuosine biosynthesis protein QueC # BioGrid 4262187 7 # CATALYTIC ACTIVITY QUEC_ECOLI 7-carboxy-7-carbaguanine + NH(3) + ATP = 7- cyano-7-carbaguanine + ADP + phosphate + H(2)O. # CDD cd01995 ExsB # COFACTOR QUEC_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000250}; Note=Binds 1 zinc ion per subunit. {ECO 0000250}; # EcoGene EG13252 queC # FUNCTION QUEC_ECOLI Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). {ECO 0000250, ECO 0000269|PubMed 16199558}. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008270 zinc ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0016879 ligase activity, forming carbon-nitrogen bonds; IEA:UniProtKB-HAMAP. # GO_process GO:0008616 queuosine biosynthetic process; IEA:UniProtKB-HAMAP. # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.620 -; 1. # HAMAP MF_01633 QueC # INTERACTION QUEC_ECOLI P0CE47 tufA; NbExp=2; IntAct=EBI-560024, EBI-301077; # IntAct P77756 14 # InterPro IPR014729 Rossmann-like_a/b/a_fold # InterPro IPR018317 QueC # KEGG_Brite ko03016 Transfer RNA biogenesis # Organism QUEC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11587:SF3 PTHR11587:SF3 # PATHWAY QUEC_ECOLI Purine metabolism; 7-cyano-7-deazaguanine biosynthesis. # PATRIC 32116041 VBIEscCol129921_0462 # PIR D64774 D64774 # PIRSF PIRSF006293 ExsB # Pfam PF06508 QueC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName QUEC_ECOLI 7-cyano-7-deazaguanine synthase # RefSeq NP_414978 NC_000913.3 # RefSeq WP_000817220 NZ_LN832404.1 # SIMILARITY Belongs to the QueC family. {ECO 0000305}. # TIGRFAMs TIGR00364 TIGR00364 # eggNOG COG0603 LUCA # eggNOG ENOG4105FD2 Bacteria BLAST swissprot:QUEC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:QUEC_ECOLI BioCyc ECOL316407:JW0434-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0434-MONOMER BioCyc EcoCyc:G6245-MONOMER http://biocyc.org/getid?id=EcoCyc:G6245-MONOMER BioCyc MetaCyc:G6245-MONOMER http://biocyc.org/getid?id=MetaCyc:G6245-MONOMER COG COG0603 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0603 DIP DIP-11311N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11311N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.187.20.6893-6901.2005 http://dx.doi.org/10.1128/JB.187.20.6893-6901.2005 EC_number EC:6.3.4.20 http://www.genome.jp/dbget-bin/www_bget?EC:6.3.4.20 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D82943 http://www.ebi.ac.uk/ena/data/view/D82943 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 ENZYME 6.3.4.20 http://enzyme.expasy.org/EC/6.3.4.20 EchoBASE EB3041 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3041 EcoGene EG13252 http://www.ecogene.org/geneInfo.php?eg_id=EG13252 EnsemblBacteria AAC73547 http://www.ensemblgenomes.org/id/AAC73547 EnsemblBacteria AAC73547 http://www.ensemblgenomes.org/id/AAC73547 EnsemblBacteria BAE76224 http://www.ensemblgenomes.org/id/BAE76224 EnsemblBacteria BAE76224 http://www.ensemblgenomes.org/id/BAE76224 EnsemblBacteria BAE76224 http://www.ensemblgenomes.org/id/BAE76224 EnsemblBacteria b0444 http://www.ensemblgenomes.org/id/b0444 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0016879 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016879 GO_process GO:0008616 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008616 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 GeneID 947034 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947034 HAMAP MF_01633 http://hamap.expasy.org/unirule/MF_01633 HOGENOM HOG000110563 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000110563&db=HOGENOM6 InParanoid P77756 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77756 IntAct P77756 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77756* IntEnz 6.3.4.20 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.4.20 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 InterPro IPR018317 http://www.ebi.ac.uk/interpro/entry/IPR018317 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW0434 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0434 KEGG_Gene eco:b0444 http://www.genome.jp/dbget-bin/www_bget?eco:b0444 KEGG_Orthology KO:K06920 http://www.genome.jp/dbget-bin/www_bget?KO:K06920 MINT MINT-1259911 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1259911 OMA MAVSYAE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MAVSYAE PANTHER PTHR11587:SF3 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11587:SF3 PSORT swissprot:QUEC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:QUEC_ECOLI PSORT-B swissprot:QUEC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:QUEC_ECOLI PSORT2 swissprot:QUEC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:QUEC_ECOLI Pfam PF06508 http://pfam.xfam.org/family/PF06508 Phobius swissprot:QUEC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:QUEC_ECOLI PhylomeDB P77756 http://phylomedb.org/?seqid=P77756 ProteinModelPortal P77756 http://www.proteinmodelportal.org/query/uniprot/P77756 PubMed 16199558 http://www.ncbi.nlm.nih.gov/pubmed/16199558 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414978 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414978 RefSeq WP_000817220 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000817220 SMR P77756 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77756 STRING 511145.b0444 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0444&targetmode=cogs STRING COG0603 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0603&targetmode=cogs TIGRFAMs TIGR00364 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00364 UniProtKB QUEC_ECOLI http://www.uniprot.org/uniprot/QUEC_ECOLI UniProtKB-AC P77756 http://www.uniprot.org/uniprot/P77756 charge swissprot:QUEC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:QUEC_ECOLI eggNOG COG0603 http://eggnogapi.embl.de/nog_data/html/tree/COG0603 eggNOG ENOG4105FD2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FD2 epestfind swissprot:QUEC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:QUEC_ECOLI garnier swissprot:QUEC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:QUEC_ECOLI helixturnhelix swissprot:QUEC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:QUEC_ECOLI hmoment swissprot:QUEC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:QUEC_ECOLI iep swissprot:QUEC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:QUEC_ECOLI inforesidue swissprot:QUEC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:QUEC_ECOLI octanol swissprot:QUEC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:QUEC_ECOLI pepcoil swissprot:QUEC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:QUEC_ECOLI pepdigest swissprot:QUEC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:QUEC_ECOLI pepinfo swissprot:QUEC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:QUEC_ECOLI pepnet swissprot:QUEC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:QUEC_ECOLI pepstats swissprot:QUEC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:QUEC_ECOLI pepwheel swissprot:QUEC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:QUEC_ECOLI pepwindow swissprot:QUEC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:QUEC_ECOLI sigcleave swissprot:QUEC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:QUEC_ECOLI ## Database ID URL or Descriptions # BioGrid 4262455 16 # EcoGene EG11605 smg # HAMAP MF_00598 Smg # IntAct P0A828 10 # InterPro IPR007456 Smg # Organism SMG_ECOLI Escherichia coli (strain K12) # PATRIC 32122002 VBIEscCol129921_3378 # PIR G65120 G65120 # Pfam PF04361 DUF494 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Protein Smg {ECO:0000255|HAMAP-Rule MF_00598} # RefSeq NP_417743 NC_000913.3 # RefSeq WP_000460680 NZ_LN832404.1 # SIMILARITY Belongs to the Smg family. {ECO:0000255|HAMAP- Rule MF_00598}. # eggNOG COG2922 LUCA # eggNOG ENOG4108RPN Bacteria BLAST swissprot:SMG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SMG_ECOLI BioCyc ECOL316407:JW3245-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3245-MONOMER BioCyc EcoCyc:EG11605-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11605-MONOMER COG COG2922 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2922 DIP DIP-48122N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48122N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X65946 http://www.ebi.ac.uk/ena/data/view/X65946 EMBL X77091 http://www.ebi.ac.uk/ena/data/view/X77091 EchoBASE EB1562 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1562 EcoGene EG11605 http://www.ecogene.org/geneInfo.php?eg_id=EG11605 EnsemblBacteria AAC76309 http://www.ensemblgenomes.org/id/AAC76309 EnsemblBacteria AAC76309 http://www.ensemblgenomes.org/id/AAC76309 EnsemblBacteria BAE78007 http://www.ensemblgenomes.org/id/BAE78007 EnsemblBacteria BAE78007 http://www.ensemblgenomes.org/id/BAE78007 EnsemblBacteria BAE78007 http://www.ensemblgenomes.org/id/BAE78007 EnsemblBacteria b3284 http://www.ensemblgenomes.org/id/b3284 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947781 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947781 HAMAP MF_00598 http://hamap.expasy.org/unirule/MF_00598 HOGENOM HOG000137865 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000137865&db=HOGENOM6 IntAct P0A828 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A828* InterPro IPR007456 http://www.ebi.ac.uk/interpro/entry/IPR007456 KEGG_Gene ecj:JW3245 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3245 KEGG_Gene eco:b3284 http://www.genome.jp/dbget-bin/www_bget?eco:b3284 KEGG_Orthology KO:K03747 http://www.genome.jp/dbget-bin/www_bget?KO:K03747 OMA IHNETEM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IHNETEM PSORT swissprot:SMG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SMG_ECOLI PSORT-B swissprot:SMG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SMG_ECOLI PSORT2 swissprot:SMG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SMG_ECOLI Pfam PF04361 http://pfam.xfam.org/family/PF04361 Phobius swissprot:SMG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SMG_ECOLI ProteinModelPortal P0A828 http://www.proteinmodelportal.org/query/uniprot/P0A828 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8432722 http://www.ncbi.nlm.nih.gov/pubmed/8432722 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417743 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417743 RefSeq WP_000460680 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000460680 STRING 511145.b3284 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3284&targetmode=cogs STRING COG2922 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2922&targetmode=cogs UniProtKB SMG_ECOLI http://www.uniprot.org/uniprot/SMG_ECOLI UniProtKB-AC P0A828 http://www.uniprot.org/uniprot/P0A828 charge swissprot:SMG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SMG_ECOLI eggNOG COG2922 http://eggnogapi.embl.de/nog_data/html/tree/COG2922 eggNOG ENOG4108RPN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108RPN epestfind swissprot:SMG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SMG_ECOLI garnier swissprot:SMG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SMG_ECOLI helixturnhelix swissprot:SMG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SMG_ECOLI hmoment swissprot:SMG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SMG_ECOLI iep swissprot:SMG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SMG_ECOLI inforesidue swissprot:SMG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SMG_ECOLI octanol swissprot:SMG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SMG_ECOLI pepcoil swissprot:SMG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SMG_ECOLI pepdigest swissprot:SMG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SMG_ECOLI pepinfo swissprot:SMG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SMG_ECOLI pepnet swissprot:SMG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SMG_ECOLI pepstats swissprot:SMG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SMG_ECOLI pepwheel swissprot:SMG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SMG_ECOLI pepwindow swissprot:SMG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SMG_ECOLI sigcleave swissprot:SMG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SMG_ECOLI ## Database ID URL or Descriptions # BioGrid 4260966 8 # CATALYTIC ACTIVITY SQUV_ECOLI ATP + 6-deoxy-6-sulfo-D-fructose = ADP + 6- deoxy-6-sulfo-D-fructose 1-phosphate. {ECO 0000255|HAMAP- Rule MF_00999, ECO 0000269|PubMed 24463506}. # DISRUPTION PHENOTYPE Mutant fails to grow on sulfoquinovose as a sole carbon source. {ECO:0000269|PubMed 24463506}. # EcoGene EG11848 yihV # FUNCTION SQUV_ECOLI Phosphorylates 6-deoxy-6-sulfo-D-fructose (SF) to 6- deoxy-6-sulfo-D-fructose 1-phosphate (SFP). {ECO 0000255|HAMAP- Rule MF_00999, ECO 0000269|PubMed 24463506}. # GO_function GO:0004747 ribokinase activity; IEA:InterPro. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0061594 6-deoxy-6-sulfofructose kinase activity; IDA:EcoCyc. # GO_process GO:0006014 D-ribose metabolic process; IEA:InterPro. # GO_process GO:0046835 carbohydrate phosphorylation; IDA:EcoCyc. # GO_process GO:1902777 6-sulfoquinovose(1-) catabolic process; IMP:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.1190.20 -; 1. # HAMAP MF_00999 SF_kinase # INDUCTION Induced during growth with sulfoquinovose. {ECO:0000269|PubMed 24463506}. # InterPro IPR002139 Ribo/fructo_kinase # InterPro IPR002173 Carboh/pur_kinase_PfkB_CS # InterPro IPR011611 PfkB_dom # InterPro IPR029056 Ribokinase-like # InterPro IPR030877 SF_kinase # Organism SQUV_ECOLI Escherichia coli (strain K12) # PATRIC 32123269 VBIEscCol129921_3995 # PIR S40827 S40827 # PRINTS PR00990 RIBOKINASE # PROSITE PS00584 PFKB_KINASES_2 # Pfam PF00294 PfkB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Sulfofructose kinase {ECO:0000255|HAMAP-Rule MF_00999} # RefSeq NP_418319 NC_000913.3 # RefSeq WP_000621656 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB03016.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the carbohydrate kinase PfkB family. {ECO:0000255|HAMAP-Rule MF_00999}. # SUPFAM SSF53613 SSF53613 # eggNOG ENOG4108MGF Bacteria # eggNOG ENOG410YU6C LUCA BLAST swissprot:SQUV_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SQUV_ECOLI BioCyc ECOL316407:JW5568-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5568-MONOMER BioCyc EcoCyc:EG11848-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11848-MONOMER BioCyc MetaCyc:EG11848-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11848-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature12947 http://dx.doi.org/10.1038/nature12947 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.184 {ECO:0000255|HAMAP-Rule:MF_00999} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.184 {ECO:0000255|HAMAP-Rule:MF_00999} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.184 {ECO:0000255|HAMAP-Rule:MF_00999} http://enzyme.expasy.org/EC/2.7.1.184 {ECO:0000255|HAMAP-Rule:MF_00999} EchoBASE EB1794 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1794 EcoGene EG11848 http://www.ecogene.org/geneInfo.php?eg_id=EG11848 EnsemblBacteria AAD13445 http://www.ensemblgenomes.org/id/AAD13445 EnsemblBacteria AAD13445 http://www.ensemblgenomes.org/id/AAD13445 EnsemblBacteria BAE77426 http://www.ensemblgenomes.org/id/BAE77426 EnsemblBacteria BAE77426 http://www.ensemblgenomes.org/id/BAE77426 EnsemblBacteria BAE77426 http://www.ensemblgenomes.org/id/BAE77426 EnsemblBacteria b3883 http://www.ensemblgenomes.org/id/b3883 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004747 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004747 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0061594 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061594 GO_process GO:0006014 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006014 GO_process GO:0046835 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046835 GO_process GO:1902777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902777 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.1190.20 http://www.cathdb.info/version/latest/superfamily/3.40.1190.20 GeneID 948382 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948382 HAMAP MF_00999 http://hamap.expasy.org/unirule/MF_00999 HOGENOM HOG000235950 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000235950&db=HOGENOM6 InParanoid P32143 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32143 IntEnz 2.7.1.184 {ECO:0000255|HAMAP-Rule:MF_00999} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.184 {ECO:0000255|HAMAP-Rule:MF_00999} InterPro IPR002139 http://www.ebi.ac.uk/interpro/entry/IPR002139 InterPro IPR002173 http://www.ebi.ac.uk/interpro/entry/IPR002173 InterPro IPR011611 http://www.ebi.ac.uk/interpro/entry/IPR011611 InterPro IPR029056 http://www.ebi.ac.uk/interpro/entry/IPR029056 InterPro IPR030877 http://www.ebi.ac.uk/interpro/entry/IPR030877 KEGG_Gene ecj:JW5568 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5568 KEGG_Gene eco:b3883 http://www.genome.jp/dbget-bin/www_bget?eco:b3883 OMA ENKTMDD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ENKTMDD PRINTS PR00990 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00990 PROSITE PS00584 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00584 PSORT swissprot:SQUV_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SQUV_ECOLI PSORT-B swissprot:SQUV_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SQUV_ECOLI PSORT2 swissprot:SQUV_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SQUV_ECOLI Pfam PF00294 http://pfam.xfam.org/family/PF00294 Phobius swissprot:SQUV_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SQUV_ECOLI PhylomeDB P32143 http://phylomedb.org/?seqid=P32143 ProteinModelPortal P32143 http://www.proteinmodelportal.org/query/uniprot/P32143 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 24463506 http://www.ncbi.nlm.nih.gov/pubmed/24463506 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418319 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418319 RefSeq WP_000621656 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000621656 SMR P32143 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32143 STRING 511145.b3883 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3883&targetmode=cogs SUPFAM SSF53613 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53613 UniProtKB SQUV_ECOLI http://www.uniprot.org/uniprot/SQUV_ECOLI UniProtKB-AC P32143 http://www.uniprot.org/uniprot/P32143 charge swissprot:SQUV_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SQUV_ECOLI eggNOG ENOG4108MGF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MGF eggNOG ENOG410YU6C http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YU6C epestfind swissprot:SQUV_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SQUV_ECOLI garnier swissprot:SQUV_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SQUV_ECOLI helixturnhelix swissprot:SQUV_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SQUV_ECOLI hmoment swissprot:SQUV_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SQUV_ECOLI iep swissprot:SQUV_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SQUV_ECOLI inforesidue swissprot:SQUV_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SQUV_ECOLI octanol swissprot:SQUV_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SQUV_ECOLI pepcoil swissprot:SQUV_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SQUV_ECOLI pepdigest swissprot:SQUV_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SQUV_ECOLI pepinfo swissprot:SQUV_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SQUV_ECOLI pepnet swissprot:SQUV_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SQUV_ECOLI pepstats swissprot:SQUV_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SQUV_ECOLI pepwheel swissprot:SQUV_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SQUV_ECOLI pepwindow swissprot:SQUV_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SQUV_ECOLI sigcleave swissprot:SQUV_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SQUV_ECOLI ## Database ID URL or Descriptions # BioGrid 4261185 157 # EcoGene EG13577 wcaK # GO_function GO:0016740 transferase activity; IEA:UniProtKB-KW. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0045228 slime layer polysaccharide biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # IntAct P71242 21 # InterPro IPR007345 Polysacch_pyruvyl_Trfase # InterPro IPR023918 Colanic_acid_synth_WcaK # Organism WCAK_ECOLI Escherichia coli (strain K12) # PATHWAY WCAK_ECOLI Slime biogenesis; slime polysaccharide biosynthesis. # PATRIC 32119423 VBIEscCol129921_2122 # PIR D64970 D64970 # Pfam PF04230 PS_pyruv_trans # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName WCAK_ECOLI Colanic acid biosynthesis protein WcaK # RefSeq NP_416549 NC_000913.3 # RefSeq WP_000770780 NZ_LN832404.1 # SIMILARITY Belongs to the polysaccharide pyruvyl transferase family. {ECO 0000305}. # TIGRFAMs TIGR04006 wcaK # eggNOG COG2327 LUCA # eggNOG ENOG4105C74 Bacteria BLAST swissprot:WCAK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:WCAK_ECOLI BioCyc ECOL316407:JW2030-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2030-MONOMER BioCyc EcoCyc:G7096-MONOMER http://biocyc.org/getid?id=EcoCyc:G7096-MONOMER COG COG2327 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2327 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:2.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U38473 http://www.ebi.ac.uk/ena/data/view/U38473 ENZYME 2.-.-.- http://enzyme.expasy.org/EC/2.-.-.- EchoBASE EB3347 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3347 EcoGene EG13577 http://www.ecogene.org/geneInfo.php?eg_id=EG13577 EnsemblBacteria AAC75106 http://www.ensemblgenomes.org/id/AAC75106 EnsemblBacteria AAC75106 http://www.ensemblgenomes.org/id/AAC75106 EnsemblBacteria BAE76571 http://www.ensemblgenomes.org/id/BAE76571 EnsemblBacteria BAE76571 http://www.ensemblgenomes.org/id/BAE76571 EnsemblBacteria BAE76571 http://www.ensemblgenomes.org/id/BAE76571 EnsemblBacteria b2045 http://www.ensemblgenomes.org/id/b2045 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016740 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016740 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GO_process GO:0045228 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045228 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 946569 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946569 HOGENOM HOG000121954 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000121954&db=HOGENOM6 InParanoid P71242 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P71242 IntAct P71242 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P71242* IntEnz 2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2 InterPro IPR007345 http://www.ebi.ac.uk/interpro/entry/IPR007345 InterPro IPR023918 http://www.ebi.ac.uk/interpro/entry/IPR023918 KEGG_Gene ecj:JW2030 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2030 KEGG_Gene eco:b2045 http://www.genome.jp/dbget-bin/www_bget?eco:b2045 KEGG_Orthology KO:K16710 http://www.genome.jp/dbget-bin/www_bget?KO:K16710 OMA IMQQLGM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IMQQLGM PSORT swissprot:WCAK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:WCAK_ECOLI PSORT-B swissprot:WCAK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:WCAK_ECOLI PSORT2 swissprot:WCAK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:WCAK_ECOLI Pfam PF04230 http://pfam.xfam.org/family/PF04230 Phobius swissprot:WCAK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:WCAK_ECOLI ProteinModelPortal P71242 http://www.proteinmodelportal.org/query/uniprot/P71242 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8759852 http://www.ncbi.nlm.nih.gov/pubmed/8759852 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416549 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416549 RefSeq WP_000770780 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000770780 STRING 511145.b2045 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2045&targetmode=cogs STRING COG2327 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2327&targetmode=cogs TIGRFAMs TIGR04006 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR04006 UniProtKB WCAK_ECOLI http://www.uniprot.org/uniprot/WCAK_ECOLI UniProtKB-AC P71242 http://www.uniprot.org/uniprot/P71242 charge swissprot:WCAK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:WCAK_ECOLI eggNOG COG2327 http://eggnogapi.embl.de/nog_data/html/tree/COG2327 eggNOG ENOG4105C74 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C74 epestfind swissprot:WCAK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:WCAK_ECOLI garnier swissprot:WCAK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:WCAK_ECOLI helixturnhelix swissprot:WCAK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:WCAK_ECOLI hmoment swissprot:WCAK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:WCAK_ECOLI iep swissprot:WCAK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:WCAK_ECOLI inforesidue swissprot:WCAK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:WCAK_ECOLI octanol swissprot:WCAK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:WCAK_ECOLI pepcoil swissprot:WCAK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:WCAK_ECOLI pepdigest swissprot:WCAK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:WCAK_ECOLI pepinfo swissprot:WCAK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:WCAK_ECOLI pepnet swissprot:WCAK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:WCAK_ECOLI pepstats swissprot:WCAK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:WCAK_ECOLI pepwheel swissprot:WCAK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:WCAK_ECOLI pepwindow swissprot:WCAK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:WCAK_ECOLI sigcleave swissprot:WCAK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:WCAK_ECOLI ## Database ID URL or Descriptions # BioGrid 4262761 7 # EcoGene EG12580 yjiS # InterPro IPR009506 DUF1127 # Organism YJIS_ECOLI Escherichia coli (strain K12) # PATRIC 32124290 VBIEscCol129921_4488 # PIR S56566 S56566 # Pfam PF06568 DUF1127 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJIS_ECOLI Uncharacterized protein YjiS # RefSeq NP_418761 NC_000913.3 # RefSeq WP_000394280 NZ_LN832404.1 # eggNOG COG5457 LUCA # eggNOG ENOG4106DIZ Bacteria BLAST swissprot:YJIS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJIS_ECOLI BioCyc ECOL316407:JW4304-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4304-MONOMER BioCyc EcoCyc:G7937-MONOMER http://biocyc.org/getid?id=EcoCyc:G7937-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2467 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2467 EcoGene EG12580 http://www.ecogene.org/geneInfo.php?eg_id=EG12580 EnsemblBacteria AAC77297 http://www.ensemblgenomes.org/id/AAC77297 EnsemblBacteria AAC77297 http://www.ensemblgenomes.org/id/AAC77297 EnsemblBacteria BAE78333 http://www.ensemblgenomes.org/id/BAE78333 EnsemblBacteria BAE78333 http://www.ensemblgenomes.org/id/BAE78333 EnsemblBacteria BAE78333 http://www.ensemblgenomes.org/id/BAE78333 EnsemblBacteria b4341 http://www.ensemblgenomes.org/id/b4341 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 948903 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948903 HOGENOM HOG000267808 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267808&db=HOGENOM6 InterPro IPR009506 http://www.ebi.ac.uk/interpro/entry/IPR009506 KEGG_Gene ecj:JW4304 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4304 KEGG_Gene eco:b4341 http://www.genome.jp/dbget-bin/www_bget?eco:b4341 OMA FHENRPR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FHENRPR PSORT swissprot:YJIS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJIS_ECOLI PSORT-B swissprot:YJIS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJIS_ECOLI PSORT2 swissprot:YJIS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJIS_ECOLI Pfam PF06568 http://pfam.xfam.org/family/PF06568 Phobius swissprot:YJIS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJIS_ECOLI ProteinModelPortal P39390 http://www.proteinmodelportal.org/query/uniprot/P39390 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418761 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418761 RefSeq WP_000394280 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000394280 STRING 511145.b4341 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4341&targetmode=cogs UniProtKB YJIS_ECOLI http://www.uniprot.org/uniprot/YJIS_ECOLI UniProtKB-AC P39390 http://www.uniprot.org/uniprot/P39390 charge swissprot:YJIS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJIS_ECOLI eggNOG COG5457 http://eggnogapi.embl.de/nog_data/html/tree/COG5457 eggNOG ENOG4106DIZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106DIZ epestfind swissprot:YJIS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJIS_ECOLI garnier swissprot:YJIS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJIS_ECOLI helixturnhelix swissprot:YJIS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJIS_ECOLI hmoment swissprot:YJIS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJIS_ECOLI iep swissprot:YJIS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJIS_ECOLI inforesidue swissprot:YJIS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJIS_ECOLI octanol swissprot:YJIS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJIS_ECOLI pepcoil swissprot:YJIS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJIS_ECOLI pepdigest swissprot:YJIS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJIS_ECOLI pepinfo swissprot:YJIS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJIS_ECOLI pepnet swissprot:YJIS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJIS_ECOLI pepstats swissprot:YJIS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJIS_ECOLI pepwheel swissprot:YJIS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJIS_ECOLI pepwindow swissprot:YJIS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJIS_ECOLI sigcleave swissprot:YJIS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJIS_ECOLI ## Database ID URL or Descriptions # EcoGene EG14468 azuC # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GOslim_component GO:0005886 plasma membrane # INDUCTION AZUC_ECOLI Constitutively expressed (PubMed 19121005). Repressed in minimal glycerol medium, at low oxygen, induced by H(2)O(2), the thiol reductant diamide, at 45 degrees Celsius and at pH 5.5 (PubMed 19734316) (at protein level). Transcription is repressed by CRP. {ECO 0000269|PubMed 19121005, ECO 0000269|PubMed 19734316}. # Organism AZUC_ECOLI Escherichia coli (strain K12) # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AZUC_ECOLI Uncharacterized protein AzuC # RefSeq YP_002791245 NC_000913.3 # SUBCELLULAR LOCATION AZUC_ECOLI Cell inner membrane {ECO 0000305|PubMed 19121005, ECO 0000305|PubMed 21778229}; Peripheral membrane protein {ECO 0000305|PubMed 19121005, ECO 0000305|PubMed 21778229}. BLAST swissprot:AZUC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AZUC_ECOLI BioCyc EcoCyc:MONOMER0-2880 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2880 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M111.245696 http://dx.doi.org/10.1074/jbc.M111.245696 DOI 10.1111/j.1365-2958.2008.06495.x http://dx.doi.org/10.1111/j.1365-2958.2008.06495.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00872-09 http://dx.doi.org/10.1128/JB.00872-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14468 http://www.ecogene.org/geneInfo.php?eg_id=EG14468 EnsemblBacteria ACO59997 http://www.ensemblgenomes.org/id/ACO59997 EnsemblBacteria ACO59997 http://www.ensemblgenomes.org/id/ACO59997 EnsemblBacteria b4663 http://www.ensemblgenomes.org/id/b4663 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 7751642 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7751642 KEGG_Gene eco:b4663 http://www.genome.jp/dbget-bin/www_bget?eco:b4663 PSORT swissprot:AZUC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AZUC_ECOLI PSORT-B swissprot:AZUC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AZUC_ECOLI PSORT2 swissprot:AZUC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AZUC_ECOLI Phobius swissprot:AZUC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AZUC_ECOLI ProteinModelPortal C1P605 http://www.proteinmodelportal.org/query/uniprot/C1P605 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19121005 http://www.ncbi.nlm.nih.gov/pubmed/19121005 PubMed 19734316 http://www.ncbi.nlm.nih.gov/pubmed/19734316 PubMed 21778229 http://www.ncbi.nlm.nih.gov/pubmed/21778229 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq YP_002791245 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_002791245 STRING 511145.b4663 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4663&targetmode=cogs UniProtKB AZUC_ECOLI http://www.uniprot.org/uniprot/AZUC_ECOLI UniProtKB-AC C1P605 http://www.uniprot.org/uniprot/C1P605 charge swissprot:AZUC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AZUC_ECOLI epestfind swissprot:AZUC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AZUC_ECOLI garnier swissprot:AZUC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AZUC_ECOLI helixturnhelix swissprot:AZUC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AZUC_ECOLI hmoment swissprot:AZUC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AZUC_ECOLI iep swissprot:AZUC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AZUC_ECOLI inforesidue swissprot:AZUC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AZUC_ECOLI octanol swissprot:AZUC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AZUC_ECOLI pepcoil swissprot:AZUC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AZUC_ECOLI pepdigest swissprot:AZUC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AZUC_ECOLI pepinfo swissprot:AZUC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AZUC_ECOLI pepnet swissprot:AZUC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AZUC_ECOLI pepstats swissprot:AZUC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AZUC_ECOLI pepwheel swissprot:AZUC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AZUC_ECOLI pepwindow swissprot:AZUC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AZUC_ECOLI sigcleave swissprot:AZUC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AZUC_ECOLI ## Database ID URL or Descriptions # CAUTION There is no equivalent of this gene in strain K12 / MG1655. {ECO 0000305}. # FUNCTION INH17_ECOLI Involved in the transposition of the insertion sequence IS5. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # InterPro IPR002559 Transposase_11 # InterPro IPR008490 Transposase_InsH_N # Organism INH17_ECOLI Escherichia coli (strain K12) # Pfam PF01609 DDE_Tnp_1 # Pfam PF05598 DUF772 # RecName INH17_ECOLI Transposase InsH for insertion sequence element IS5-17 # RefSeq WP_000019403 NZ_LN832404.1 # SIMILARITY Belongs to the transposase 11 family. {ECO 0000305}. # eggNOG COG3039 LUCA # eggNOG ENOG4105F2I Bacteria BLAST swissprot:INH17_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INH17_ECOLI DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EnsemblBacteria BAE77585 http://www.ensemblgenomes.org/id/BAE77585 EnsemblBacteria BAE77585 http://www.ensemblgenomes.org/id/BAE77585 EnsemblBacteria BAE77585 http://www.ensemblgenomes.org/id/BAE77585 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 InterPro IPR002559 http://www.ebi.ac.uk/interpro/entry/IPR002559 InterPro IPR008490 http://www.ebi.ac.uk/interpro/entry/IPR008490 KEGG_Gene ecj:JW5936 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5936 PSORT swissprot:INH17_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INH17_ECOLI PSORT-B swissprot:INH17_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INH17_ECOLI PSORT2 swissprot:INH17_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INH17_ECOLI Pfam PF01609 http://pfam.xfam.org/family/PF01609 Pfam PF05598 http://pfam.xfam.org/family/PF05598 Phobius swissprot:INH17_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INH17_ECOLI PhylomeDB P0CE64 http://phylomedb.org/?seqid=P0CE64 ProteinModelPortal P0CE64 http://www.proteinmodelportal.org/query/uniprot/P0CE64 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 RefSeq WP_000019403 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000019403 SMR P0CE64 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0CE64 STRING 511145.b3505 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3505&targetmode=cogs UniProtKB INH17_ECOLI http://www.uniprot.org/uniprot/INH17_ECOLI UniProtKB-AC P0CE64 http://www.uniprot.org/uniprot/P0CE64 charge swissprot:INH17_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INH17_ECOLI eggNOG COG3039 http://eggnogapi.embl.de/nog_data/html/tree/COG3039 eggNOG ENOG4105F2I http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F2I epestfind swissprot:INH17_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INH17_ECOLI garnier swissprot:INH17_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INH17_ECOLI helixturnhelix swissprot:INH17_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INH17_ECOLI hmoment swissprot:INH17_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INH17_ECOLI iep swissprot:INH17_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INH17_ECOLI inforesidue swissprot:INH17_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INH17_ECOLI octanol swissprot:INH17_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INH17_ECOLI pepcoil swissprot:INH17_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INH17_ECOLI pepdigest swissprot:INH17_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INH17_ECOLI pepinfo swissprot:INH17_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INH17_ECOLI pepnet swissprot:INH17_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INH17_ECOLI pepstats swissprot:INH17_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INH17_ECOLI pepwheel swissprot:INH17_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INH17_ECOLI pepwindow swissprot:INH17_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INH17_ECOLI sigcleave swissprot:INH17_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INH17_ECOLI ## Database ID URL or Descriptions # BioGrid 4261628 15 # EcoGene EG13902 dhaR # FUNCTION DHAR_ECOLI Positively regulates the dhaKLM operon from a sigma-70 promoter. Represses its own synthesis. {ECO 0000269|PubMed 15616579}. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0043565 sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006071 glycerol metabolic process; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IMP:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IMP:EcoCyc. # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.10.60 -; 1. # Gene3D 3.40.50.300 -; 1. # InterPro IPR000014 PAS # InterPro IPR002078 Sigma_54_int # InterPro IPR002197 HTH_Fis # InterPro IPR003593 AAA+_ATPase # InterPro IPR009057 Homeodomain-like # InterPro IPR013767 PAS_fold # InterPro IPR025662 Sigma_54_int_dom_ATP-bd_1 # InterPro IPR025943 Sigma_54_int_dom_ATP-bd_2 # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko03000 Transcription factors # MISCELLANEOUS DhaK and DhaL-ADP bind to DhaR in a mutually exclusive manner, and act as corepressor and coactivator of DhaR, respectively. DhaK binds to the sensor domain of DhaR and keeps it in a transcription inactive state. In the presence of dihydroxyacetone, DhaR activity is activated by DhaL-ADP DhaK that binds dihydroxyacetone has less affinity for DhaR and is displaced by DhaL-ADP, which activates DhaR. # Organism DHAR_ECOLI Escherichia coli (strain K12) # PATRIC 32117652 VBIEscCol129921_1248 # PDB 4LRX X-ray; 3.25 A; C/D=1-318 # PDB 4LRY X-ray; 2.83 A; C/D=1-318 # PDB 4LRZ X-ray; 2.32 A; E/F/G/H=1-318 # PIR F64866 F64866 # PROSITE PS00675 SIGMA54_INTERACT_1 # PROSITE PS00676 SIGMA54_INTERACT_2 # PROSITE PS50045 SIGMA54_INTERACT_4 # Pfam PF00158 Sigma54_activat # Pfam PF00989 PAS # Pfam PF02954 HTH_8 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DHAR_ECOLI PTS-dependent dihydroxyacetone kinase operon regulatory protein # RefSeq NP_415719 NC_000913.3 # RefSeq WP_001350505 NZ_LN832404.1 # SIMILARITY Contains 1 GAF domain. {ECO 0000305}. # SIMILARITY Contains 1 PAS (PER-ARNT-SIM) domain. {ECO 0000305}. # SIMILARITY Contains 1 sigma-54 factor interaction domain. {ECO:0000255|PROSITE-ProRule PRU00193}. # SMART SM00091 PAS # SMART SM00382 AAA # SUPFAM SSF46689 SSF46689 # SUPFAM SSF52540 SSF52540 # SUPFAM SSF55785 SSF55785 # eggNOG COG3284 LUCA # eggNOG ENOG4108JU9 Bacteria BLAST swissprot:DHAR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DHAR_ECOLI BioCyc ECOL316407:JW5188-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5188-MONOMER BioCyc EcoCyc:G6628-MONOMER http://biocyc.org/getid?id=EcoCyc:G6628-MONOMER DIP DIP-9438N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9438N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/sj.emboj.7600517 http://dx.doi.org/10.1038/sj.emboj.7600517 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3661 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3661 EcoGene EG13902 http://www.ecogene.org/geneInfo.php?eg_id=EG13902 EnsemblBacteria AAC74285 http://www.ensemblgenomes.org/id/AAC74285 EnsemblBacteria AAC74285 http://www.ensemblgenomes.org/id/AAC74285 EnsemblBacteria BAA36058 http://www.ensemblgenomes.org/id/BAA36058 EnsemblBacteria BAA36058 http://www.ensemblgenomes.org/id/BAA36058 EnsemblBacteria BAA36058 http://www.ensemblgenomes.org/id/BAA36058 EnsemblBacteria b1201 http://www.ensemblgenomes.org/id/b1201 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006071 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945743 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945743 HOGENOM HOG000058487 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000058487&db=HOGENOM6 InParanoid P76016 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76016 IntAct P76016 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76016* InterPro IPR000014 http://www.ebi.ac.uk/interpro/entry/IPR000014 InterPro IPR002078 http://www.ebi.ac.uk/interpro/entry/IPR002078 InterPro IPR002197 http://www.ebi.ac.uk/interpro/entry/IPR002197 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR013767 http://www.ebi.ac.uk/interpro/entry/IPR013767 InterPro IPR025662 http://www.ebi.ac.uk/interpro/entry/IPR025662 InterPro IPR025943 http://www.ebi.ac.uk/interpro/entry/IPR025943 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW5188 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5188 KEGG_Gene eco:b1201 http://www.genome.jp/dbget-bin/www_bget?eco:b1201 KEGG_Orthology KO:K05880 http://www.genome.jp/dbget-bin/www_bget?KO:K05880 OMA DSTYDAI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DSTYDAI PDB 4LRX http://www.ebi.ac.uk/pdbe-srv/view/entry/4LRX PDB 4LRY http://www.ebi.ac.uk/pdbe-srv/view/entry/4LRY PDB 4LRZ http://www.ebi.ac.uk/pdbe-srv/view/entry/4LRZ PDBsum 4LRX http://www.ebi.ac.uk/pdbsum/4LRX PDBsum 4LRY http://www.ebi.ac.uk/pdbsum/4LRY PDBsum 4LRZ http://www.ebi.ac.uk/pdbsum/4LRZ PROSITE PS00675 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00675 PROSITE PS00676 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00676 PROSITE PS50045 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50045 PSORT swissprot:DHAR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DHAR_ECOLI PSORT-B swissprot:DHAR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DHAR_ECOLI PSORT2 swissprot:DHAR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DHAR_ECOLI Pfam PF00158 http://pfam.xfam.org/family/PF00158 Pfam PF00989 http://pfam.xfam.org/family/PF00989 Pfam PF02954 http://pfam.xfam.org/family/PF02954 Phobius swissprot:DHAR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DHAR_ECOLI PhylomeDB P76016 http://phylomedb.org/?seqid=P76016 ProteinModelPortal P76016 http://www.proteinmodelportal.org/query/uniprot/P76016 PubMed 15616579 http://www.ncbi.nlm.nih.gov/pubmed/15616579 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415719 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415719 RefSeq WP_001350505 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001350505 SMART SM00091 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00091 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P76016 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76016 STRING 511145.b1201 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1201&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SUPFAM SSF55785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55785 UniProtKB DHAR_ECOLI http://www.uniprot.org/uniprot/DHAR_ECOLI UniProtKB-AC P76016 http://www.uniprot.org/uniprot/P76016 charge swissprot:DHAR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DHAR_ECOLI eggNOG COG3284 http://eggnogapi.embl.de/nog_data/html/tree/COG3284 eggNOG ENOG4108JU9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108JU9 epestfind swissprot:DHAR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DHAR_ECOLI garnier swissprot:DHAR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DHAR_ECOLI helixturnhelix swissprot:DHAR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DHAR_ECOLI hmoment swissprot:DHAR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DHAR_ECOLI iep swissprot:DHAR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DHAR_ECOLI inforesidue swissprot:DHAR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DHAR_ECOLI octanol swissprot:DHAR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DHAR_ECOLI pepcoil swissprot:DHAR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DHAR_ECOLI pepdigest swissprot:DHAR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DHAR_ECOLI pepinfo swissprot:DHAR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DHAR_ECOLI pepnet swissprot:DHAR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DHAR_ECOLI pepstats swissprot:DHAR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DHAR_ECOLI pepwheel swissprot:DHAR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DHAR_ECOLI pepwindow swissprot:DHAR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DHAR_ECOLI sigcleave swissprot:DHAR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DHAR_ECOLI ## Database ID URL or Descriptions # BioGrid 4261295 258 # EcoGene EG12888 gspA # FUNCTION GSPA_ECOLI May play a regulatory role under conditions of derepressed gsp gene expression. {ECO 0000269|PubMed 11118204}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0006810 transport; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # Gene3D 1.10.101.10 -; 1. # Gene3D 3.40.50.300 -; 1. # INDUCTION Silenced by the DNA-binding protein H-NS under standard growth conditions. {ECO:0000269|PubMed 11118204}. # InterPro IPR002477 Peptidoglycan-bd-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko02044 Secretion system # MISCELLANEOUS GSPA_ECOLI Part of a cryptic operon that encodes proteins involved in type II secretion machinery in other organisms, but is not expressed in strain K12. # Organism GSPA_ECOLI Escherichia coli (strain K12) # PATRIC 32122078 VBIEscCol129921_3416 # PIR F65125 F65125 # Pfam PF01471 PG_binding_1 # Pfam PF13401 AAA_22 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GSPA_ECOLI Putative general secretion pathway protein A # RefSeq NP_417782 NC_000913.3 # RefSeq WP_000107576 NZ_LN832404.1 # SIMILARITY Belongs to the ExeA family. {ECO 0000305}. # SUBCELLULAR LOCATION GSPA_ECOLI Cell membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. # SUPFAM SSF47090 SSF47090 # SUPFAM SSF52540 SSF52540 # TCDB 9.B.42.1 the exeab (exeab) secretin assembly/export complex # eggNOG ENOG410899B Bacteria # eggNOG ENOG41120C0 LUCA BLAST swissprot:GSPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GSPA_ECOLI BioCyc ECOL316407:JW3285-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3285-MONOMER BioCyc EcoCyc:G7701-MONOMER http://biocyc.org/getid?id=EcoCyc:G7701-MONOMER COG COG3267 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3267 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/emboj/19.24.6697 http://dx.doi.org/10.1093/emboj/19.24.6697 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2725 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2725 EcoGene EG12888 http://www.ecogene.org/geneInfo.php?eg_id=EG12888 EnsemblBacteria AAC76348 http://www.ensemblgenomes.org/id/AAC76348 EnsemblBacteria AAC76348 http://www.ensemblgenomes.org/id/AAC76348 EnsemblBacteria BAE77968 http://www.ensemblgenomes.org/id/BAE77968 EnsemblBacteria BAE77968 http://www.ensemblgenomes.org/id/BAE77968 EnsemblBacteria BAE77968 http://www.ensemblgenomes.org/id/BAE77968 EnsemblBacteria b3323 http://www.ensemblgenomes.org/id/b3323 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 1.10.101.10 http://www.cathdb.info/version/latest/superfamily/1.10.101.10 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947825 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947825 HOGENOM HOG000009790 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009790&db=HOGENOM6 InParanoid P45756 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45756 IntAct P45756 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45756* InterPro IPR002477 http://www.ebi.ac.uk/interpro/entry/IPR002477 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW3285 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3285 KEGG_Gene eco:b3323 http://www.genome.jp/dbget-bin/www_bget?eco:b3323 KEGG_Orthology KO:K02450 http://www.genome.jp/dbget-bin/www_bget?KO:K02450 OMA WFTRHFS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WFTRHFS PSORT swissprot:GSPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GSPA_ECOLI PSORT-B swissprot:GSPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GSPA_ECOLI PSORT2 swissprot:GSPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GSPA_ECOLI Pfam PF01471 http://pfam.xfam.org/family/PF01471 Pfam PF13401 http://pfam.xfam.org/family/PF13401 Phobius swissprot:GSPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GSPA_ECOLI ProteinModelPortal P45756 http://www.proteinmodelportal.org/query/uniprot/P45756 PubMed 11118204 http://www.ncbi.nlm.nih.gov/pubmed/11118204 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8655552 http://www.ncbi.nlm.nih.gov/pubmed/8655552 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417782 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417782 RefSeq WP_000107576 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000107576 SMR P45756 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45756 STRING 511145.b3323 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3323&targetmode=cogs STRING COG3267 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3267&targetmode=cogs SUPFAM SSF47090 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47090 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 9.B.42.1 http://www.tcdb.org/search/result.php?tc=9.B.42.1 UniProtKB GSPA_ECOLI http://www.uniprot.org/uniprot/GSPA_ECOLI UniProtKB-AC P45756 http://www.uniprot.org/uniprot/P45756 charge swissprot:GSPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GSPA_ECOLI eggNOG ENOG410899B http://eggnogapi.embl.de/nog_data/html/tree/ENOG410899B eggNOG ENOG41120C0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41120C0 epestfind swissprot:GSPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GSPA_ECOLI garnier swissprot:GSPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GSPA_ECOLI helixturnhelix swissprot:GSPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GSPA_ECOLI hmoment swissprot:GSPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GSPA_ECOLI iep swissprot:GSPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GSPA_ECOLI inforesidue swissprot:GSPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GSPA_ECOLI octanol swissprot:GSPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GSPA_ECOLI pepcoil swissprot:GSPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GSPA_ECOLI pepdigest swissprot:GSPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GSPA_ECOLI pepinfo swissprot:GSPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GSPA_ECOLI pepnet swissprot:GSPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GSPA_ECOLI pepstats swissprot:GSPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GSPA_ECOLI pepwheel swissprot:GSPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GSPA_ECOLI pepwindow swissprot:GSPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GSPA_ECOLI sigcleave swissprot:GSPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GSPA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260546 9 # EcoGene EG14135 yfdK # GO_process GO:0006979 response to oxidative stress; IMP:EcoCyc. # GOslim_process GO:0006950 response to stress # IntAct P77656 5 # InterPro IPR003458 Phage_T4_Gp38_tail_assem # Organism YFDK_ECOLI Escherichia coli (strain K12) # PATRIC 32120081 VBIEscCol129921_2449 # PIR G65008 G65008 # Pfam PF02413 Caudo_TAP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFDK_ECOLI Uncharacterized protein YfdK # RefSeq NP_416855 NC_000913.3 # RefSeq WP_001106835 NZ_LN832404.1 # SIMILARITY To E.coli YmfS. {ECO 0000305}. # eggNOG ENOG4105PTU Bacteria # eggNOG ENOG4111Y3Y LUCA BLAST swissprot:YFDK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFDK_ECOLI BioCyc ECOL316407:JW2350-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2350-MONOMER BioCyc EcoCyc:G7223-MONOMER http://biocyc.org/getid?id=EcoCyc:G7223-MONOMER DIP DIP-11999N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11999N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3887 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3887 EcoGene EG14135 http://www.ecogene.org/geneInfo.php?eg_id=EG14135 EnsemblBacteria AAC75413 http://www.ensemblgenomes.org/id/AAC75413 EnsemblBacteria AAC75413 http://www.ensemblgenomes.org/id/AAC75413 EnsemblBacteria BAA16214 http://www.ensemblgenomes.org/id/BAA16214 EnsemblBacteria BAA16214 http://www.ensemblgenomes.org/id/BAA16214 EnsemblBacteria BAA16214 http://www.ensemblgenomes.org/id/BAA16214 EnsemblBacteria b2354 http://www.ensemblgenomes.org/id/b2354 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 948822 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948822 HOGENOM HOG000118672 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118672&db=HOGENOM6 IntAct P77656 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77656* InterPro IPR003458 http://www.ebi.ac.uk/interpro/entry/IPR003458 KEGG_Gene ecj:JW2350 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2350 KEGG_Gene eco:b2354 http://www.genome.jp/dbget-bin/www_bget?eco:b2354 OMA YINANSW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YINANSW PSORT swissprot:YFDK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFDK_ECOLI PSORT-B swissprot:YFDK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFDK_ECOLI PSORT2 swissprot:YFDK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFDK_ECOLI Pfam PF02413 http://pfam.xfam.org/family/PF02413 Phobius swissprot:YFDK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFDK_ECOLI ProteinModelPortal P77656 http://www.proteinmodelportal.org/query/uniprot/P77656 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416855 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416855 RefSeq WP_001106835 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001106835 SMR P77656 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77656 STRING 511145.b2354 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2354&targetmode=cogs UniProtKB YFDK_ECOLI http://www.uniprot.org/uniprot/YFDK_ECOLI UniProtKB-AC P77656 http://www.uniprot.org/uniprot/P77656 charge swissprot:YFDK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFDK_ECOLI eggNOG ENOG4105PTU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105PTU eggNOG ENOG4111Y3Y http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111Y3Y epestfind swissprot:YFDK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFDK_ECOLI garnier swissprot:YFDK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFDK_ECOLI helixturnhelix swissprot:YFDK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFDK_ECOLI hmoment swissprot:YFDK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFDK_ECOLI iep swissprot:YFDK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFDK_ECOLI inforesidue swissprot:YFDK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFDK_ECOLI octanol swissprot:YFDK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFDK_ECOLI pepcoil swissprot:YFDK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFDK_ECOLI pepdigest swissprot:YFDK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFDK_ECOLI pepinfo swissprot:YFDK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFDK_ECOLI pepnet swissprot:YFDK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFDK_ECOLI pepstats swissprot:YFDK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFDK_ECOLI pepwheel swissprot:YFDK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFDK_ECOLI pepwindow swissprot:YFDK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFDK_ECOLI sigcleave swissprot:YFDK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFDK_ECOLI ## Database ID URL or Descriptions # BioGrid 4260344 9 # EcoGene EG14306 yoaH # HAMAP MF_00507 UPF0181 # IntAct P67338 4 # InterPro IPR005371 UPF0181 # Organism YOAH_ECOLI Escherichia coli (strain K12) # PATRIC 32118941 VBIEscCol129921_1888 # PIR C64942 C64942 # Pfam PF03701 UPF0181 # ProDom PD026807 UPF0181 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UPF0181 protein YoaH {ECO:0000255|HAMAP-Rule MF_00507} # RefSeq NP_416325 NC_000913.3 # RefSeq WP_000457334 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0181 family. {ECO:0000255|HAMAP- Rule MF_00507}. # eggNOG COG3140 LUCA # eggNOG ENOG4105X5C Bacteria BLAST swissprot:YOAH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YOAH_ECOLI BioCyc ECOL316407:JW1800-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1800-MONOMER BioCyc EcoCyc:G6995-MONOMER http://biocyc.org/getid?id=EcoCyc:G6995-MONOMER COG COG3140 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3140 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4053 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4053 EcoGene EG14306 http://www.ecogene.org/geneInfo.php?eg_id=EG14306 EnsemblBacteria AAC74881 http://www.ensemblgenomes.org/id/AAC74881 EnsemblBacteria AAC74881 http://www.ensemblgenomes.org/id/AAC74881 EnsemblBacteria BAE76535 http://www.ensemblgenomes.org/id/BAE76535 EnsemblBacteria BAE76535 http://www.ensemblgenomes.org/id/BAE76535 EnsemblBacteria BAE76535 http://www.ensemblgenomes.org/id/BAE76535 EnsemblBacteria b1811 http://www.ensemblgenomes.org/id/b1811 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946346 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946346 HAMAP MF_00507 http://hamap.expasy.org/unirule/MF_00507 HOGENOM HOG000218393 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218393&db=HOGENOM6 IntAct P67338 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P67338* InterPro IPR005371 http://www.ebi.ac.uk/interpro/entry/IPR005371 KEGG_Gene ecj:JW1800 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1800 KEGG_Gene eco:b1811 http://www.genome.jp/dbget-bin/www_bget?eco:b1811 KEGG_Orthology KO:K09917 http://www.genome.jp/dbget-bin/www_bget?KO:K09917 OMA IPALTHE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IPALTHE PSORT swissprot:YOAH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YOAH_ECOLI PSORT-B swissprot:YOAH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YOAH_ECOLI PSORT2 swissprot:YOAH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YOAH_ECOLI Pfam PF03701 http://pfam.xfam.org/family/PF03701 Phobius swissprot:YOAH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YOAH_ECOLI ProteinModelPortal P67338 http://www.proteinmodelportal.org/query/uniprot/P67338 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416325 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416325 RefSeq WP_000457334 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000457334 STRING 511145.b1811 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1811&targetmode=cogs STRING COG3140 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3140&targetmode=cogs UniProtKB YOAH_ECOLI http://www.uniprot.org/uniprot/YOAH_ECOLI UniProtKB-AC P67338 http://www.uniprot.org/uniprot/P67338 charge swissprot:YOAH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YOAH_ECOLI eggNOG COG3140 http://eggnogapi.embl.de/nog_data/html/tree/COG3140 eggNOG ENOG4105X5C http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105X5C epestfind swissprot:YOAH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YOAH_ECOLI garnier swissprot:YOAH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YOAH_ECOLI helixturnhelix swissprot:YOAH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YOAH_ECOLI hmoment swissprot:YOAH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YOAH_ECOLI iep swissprot:YOAH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YOAH_ECOLI inforesidue swissprot:YOAH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YOAH_ECOLI octanol swissprot:YOAH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YOAH_ECOLI pepcoil swissprot:YOAH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YOAH_ECOLI pepdigest swissprot:YOAH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YOAH_ECOLI pepinfo swissprot:YOAH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YOAH_ECOLI pepnet swissprot:YOAH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YOAH_ECOLI pepstats swissprot:YOAH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YOAH_ECOLI pepwheel swissprot:YOAH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YOAH_ECOLI pepwindow swissprot:YOAH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YOAH_ECOLI sigcleave swissprot:YOAH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YOAH_ECOLI ## Database ID URL or Descriptions # BioGrid 4262951 161 # EcoGene EG11952 mdtP # FUNCTION MDTP_ECOLI Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride. {ECO 0000269|PubMed 11257026}. # GO_component GO:0009279 cell outer membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0008289 lipid binding; IEA:InterPro. # GO_function GO:0015546 sulfathiazole transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0015906 sulfathiazole transport; IMP:EcoCyc. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0008289 lipid binding # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # IntAct P32714 3 # InterPro IPR003423 OMP_efflux # InterPro IPR010131 RND_efflux_OM_lipoprot_NodT # KEGG_Brite ko02000 Transporters # Organism MDTP_ECOLI Escherichia coli (strain K12) # PATRIC 32123713 VBIEscCol129921_4205 # PIR G65216 G65216 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF02321 OEP; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MDTP_ECOLI Multidrug resistance outer membrane protein MdtP # RefSeq NP_418504 NC_000913.3 # RefSeq WP_000610601 NZ_LN832404.1 # SIMILARITY Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. {ECO 0000305}. # SUBCELLULAR LOCATION MDTP_ECOLI Cell outer membrane {ECO 0000305}; Lipid- anchor {ECO 0000255|PROSITE-ProRule PRU00303}. # SUBUNIT MDTP_ECOLI Could be part of a tripartite efflux system composed of MdtN, MdtO and MdtP. # TCDB 1.B.17.3 the outer membrane factor (omf) family # TIGRFAMs TIGR01845 outer_NodT # eggNOG COG1538 LUCA # eggNOG ENOG4105ETP Bacteria BLAST swissprot:MDTP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MDTP_ECOLI BioCyc ECOL316407:JW4041-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4041-MONOMER BioCyc EcoCyc:EG11952-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11952-MONOMER COG COG1538 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1538 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AAC.45.4.1126-1136.2001 http://dx.doi.org/10.1128/AAC.45.4.1126-1136.2001 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1895 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1895 EcoGene EG11952 http://www.ecogene.org/geneInfo.php?eg_id=EG11952 EnsemblBacteria AAD13463 http://www.ensemblgenomes.org/id/AAD13463 EnsemblBacteria AAD13463 http://www.ensemblgenomes.org/id/AAD13463 EnsemblBacteria BAE78082 http://www.ensemblgenomes.org/id/BAE78082 EnsemblBacteria BAE78082 http://www.ensemblgenomes.org/id/BAE78082 EnsemblBacteria BAE78082 http://www.ensemblgenomes.org/id/BAE78082 EnsemblBacteria b4080 http://www.ensemblgenomes.org/id/b4080 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289 GO_function GO:0015546 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015546 GO_process GO:0015906 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015906 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0008289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 948583 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948583 HOGENOM HOG000122243 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122243&db=HOGENOM6 InParanoid P32714 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32714 IntAct P32714 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32714* InterPro IPR003423 http://www.ebi.ac.uk/interpro/entry/IPR003423 InterPro IPR010131 http://www.ebi.ac.uk/interpro/entry/IPR010131 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW4041 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4041 KEGG_Gene eco:b4080 http://www.genome.jp/dbget-bin/www_bget?eco:b4080 KEGG_Orthology KO:K15550 http://www.genome.jp/dbget-bin/www_bget?KO:K15550 OMA GQIKETR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GQIKETR PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:MDTP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MDTP_ECOLI PSORT-B swissprot:MDTP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MDTP_ECOLI PSORT2 swissprot:MDTP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MDTP_ECOLI Pfam PF02321 http://pfam.xfam.org/family/PF02321 Phobius swissprot:MDTP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MDTP_ECOLI PhylomeDB P32714 http://phylomedb.org/?seqid=P32714 ProteinModelPortal P32714 http://www.proteinmodelportal.org/query/uniprot/P32714 PubMed 11257026 http://www.ncbi.nlm.nih.gov/pubmed/11257026 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418504 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418504 RefSeq WP_000610601 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000610601 SMR P32714 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32714 STRING 511145.b4080 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4080&targetmode=cogs STRING COG1538 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1538&targetmode=cogs TCDB 1.B.17.3 http://www.tcdb.org/search/result.php?tc=1.B.17.3 TIGRFAMs TIGR01845 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01845 UniProtKB MDTP_ECOLI http://www.uniprot.org/uniprot/MDTP_ECOLI UniProtKB-AC P32714 http://www.uniprot.org/uniprot/P32714 charge swissprot:MDTP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MDTP_ECOLI eggNOG COG1538 http://eggnogapi.embl.de/nog_data/html/tree/COG1538 eggNOG ENOG4105ETP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ETP epestfind swissprot:MDTP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MDTP_ECOLI garnier swissprot:MDTP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MDTP_ECOLI helixturnhelix swissprot:MDTP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MDTP_ECOLI hmoment swissprot:MDTP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MDTP_ECOLI iep swissprot:MDTP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MDTP_ECOLI inforesidue swissprot:MDTP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MDTP_ECOLI octanol swissprot:MDTP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MDTP_ECOLI pepcoil swissprot:MDTP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MDTP_ECOLI pepdigest swissprot:MDTP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MDTP_ECOLI pepinfo swissprot:MDTP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MDTP_ECOLI pepnet swissprot:MDTP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MDTP_ECOLI pepstats swissprot:MDTP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MDTP_ECOLI pepwheel swissprot:MDTP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MDTP_ECOLI pepwindow swissprot:MDTP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MDTP_ECOLI sigcleave swissprot:MDTP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MDTP_ECOLI ## Database ID URL or Descriptions # BioGrid 4259611 9 # EcoGene EG11472 rmuC # FUNCTION RMUC_ECOLI Involved in DNA recombination. # GO_process GO:0006310 DNA recombination; IMP:EcoCyc. # GOslim_process GO:0006259 DNA metabolic process # IntAct P0AG71 7 # InterPro IPR003798 DNA_recombination_RmuC # Organism RMUC_ECOLI Escherichia coli (strain K12) # PATRIC 32123165 VBIEscCol129921_3948 # PIR A65188 A65188 # Pfam PF02646 RmuC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RMUC_ECOLI DNA recombination protein RmuC # RefSeq NP_418276 NC_000913.3 # RefSeq WP_000347714 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=X15689; Type=Frameshift; Positions=464; Evidence={ECO 0000305}; # SIMILARITY Belongs to the RmuC family. {ECO 0000305}. # eggNOG COG1322 LUCA # eggNOG ENOG4105CGY Bacteria BLAST swissprot:RMUC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RMUC_ECOLI BioCyc ECOL316407:JW3809-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3809-MONOMER BioCyc EcoCyc:EG11472-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11472-MONOMER COG COG1322 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1322 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2443.2000.00341.x http://dx.doi.org/10.1046/j.1365-2443.2000.00341.x DOI 10.1093/nar/17.16.6741 http://dx.doi.org/10.1093/nar/17.16.6741 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AF300647 http://www.ebi.ac.uk/ena/data/view/AF300647 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X15689 http://www.ebi.ac.uk/ena/data/view/X15689 EchoBASE EB1440 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1440 EcoGene EG11472 http://www.ecogene.org/geneInfo.php?eg_id=EG11472 EnsemblBacteria AAC76835 http://www.ensemblgenomes.org/id/AAC76835 EnsemblBacteria AAC76835 http://www.ensemblgenomes.org/id/AAC76835 EnsemblBacteria BAE77469 http://www.ensemblgenomes.org/id/BAE77469 EnsemblBacteria BAE77469 http://www.ensemblgenomes.org/id/BAE77469 EnsemblBacteria BAE77469 http://www.ensemblgenomes.org/id/BAE77469 EnsemblBacteria b3832 http://www.ensemblgenomes.org/id/b3832 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GeneID 948966 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948966 HOGENOM HOG000270056 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000270056&db=HOGENOM6 InParanoid P0AG71 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AG71 IntAct P0AG71 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AG71* InterPro IPR003798 http://www.ebi.ac.uk/interpro/entry/IPR003798 KEGG_Gene ecj:JW3809 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3809 KEGG_Gene eco:b3832 http://www.genome.jp/dbget-bin/www_bget?eco:b3832 KEGG_Orthology KO:K09760 http://www.genome.jp/dbget-bin/www_bget?KO:K09760 OMA HGKLMAA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HGKLMAA PSORT swissprot:RMUC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RMUC_ECOLI PSORT-B swissprot:RMUC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RMUC_ECOLI PSORT2 swissprot:RMUC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RMUC_ECOLI Pfam PF02646 http://pfam.xfam.org/family/PF02646 Phobius swissprot:RMUC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RMUC_ECOLI PhylomeDB P0AG71 http://phylomedb.org/?seqid=P0AG71 ProteinModelPortal P0AG71 http://www.proteinmodelportal.org/query/uniprot/P0AG71 PubMed 10886369 http://www.ncbi.nlm.nih.gov/pubmed/10886369 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2674901 http://www.ncbi.nlm.nih.gov/pubmed/2674901 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418276 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418276 RefSeq WP_000347714 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000347714 SMR P0AG71 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AG71 STRING 511145.b3832 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3832&targetmode=cogs STRING COG1322 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1322&targetmode=cogs UniProtKB RMUC_ECOLI http://www.uniprot.org/uniprot/RMUC_ECOLI UniProtKB-AC P0AG71 http://www.uniprot.org/uniprot/P0AG71 charge swissprot:RMUC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RMUC_ECOLI eggNOG COG1322 http://eggnogapi.embl.de/nog_data/html/tree/COG1322 eggNOG ENOG4105CGY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CGY epestfind swissprot:RMUC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RMUC_ECOLI garnier swissprot:RMUC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RMUC_ECOLI helixturnhelix swissprot:RMUC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RMUC_ECOLI hmoment swissprot:RMUC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RMUC_ECOLI iep swissprot:RMUC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RMUC_ECOLI inforesidue swissprot:RMUC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RMUC_ECOLI octanol swissprot:RMUC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RMUC_ECOLI pepcoil swissprot:RMUC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RMUC_ECOLI pepdigest swissprot:RMUC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RMUC_ECOLI pepinfo swissprot:RMUC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RMUC_ECOLI pepnet swissprot:RMUC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RMUC_ECOLI pepstats swissprot:RMUC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RMUC_ECOLI pepwheel swissprot:RMUC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RMUC_ECOLI pepwindow swissprot:RMUC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RMUC_ECOLI sigcleave swissprot:RMUC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RMUC_ECOLI ## Database ID URL or Descriptions # BioGrid 4259938 2 # EcoGene EG11700 pnuC # FUNCTION PNUC_ECOLI Required for nicotinamide riboside transport across the inner membrane. {ECO 0000269|PubMed 15561822}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0034257 nicotinamide riboside transmembrane transporter activity; IDA:EcoCyc. # GO_process GO:0034258 nicotinamide riboside transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # INDUCTION PNUC_ECOLI Repressed by NadR. # InterPro IPR006419 NMN_transpt_PnuC # KEGG_Brite ko02000 Transporters # Organism PNUC_ECOLI Escherichia coli (strain K12) # PATRIC 32116701 VBIEscCol129921_0776 # PIR G64810 G64810 # Pfam PF04973 NMN_transporter # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PNUC_ECOLI Nicotinamide riboside transporter PnuC # RefSeq NP_415272 NC_000913.3 # RefSeq WP_000345410 NZ_LN832404.1 # SIMILARITY Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family. {ECO 0000305}. # SUBCELLULAR LOCATION PNUC_ECOLI Cell inner membrane {ECO 0000269|PubMed 15561822}; Multi-pass membrane protein {ECO 0000305|PubMed 15561822, ECO 0000305|PubMed 15919996}. # TIGRFAMs TIGR01528 NMN_trans_PnuC # eggNOG COG3201 LUCA # eggNOG ENOG4106Z1T Bacteria BLAST swissprot:PNUC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PNUC_ECOLI BioCyc ECOL316407:JW0734-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0734-MONOMER BioCyc EcoCyc:PNUC-MONOMER http://biocyc.org/getid?id=EcoCyc:PNUC-MONOMER BioCyc MetaCyc:PNUC-MONOMER http://biocyc.org/getid?id=MetaCyc:PNUC-MONOMER COG COG3201 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3201 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1432-1033.1988.tb14187.x http://dx.doi.org/10.1111/j.1432-1033.1988.tb14187.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AAC.48.12.4532-4541.2004 http://dx.doi.org/10.1128/AAC.48.12.4532-4541.2004 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X12713 http://www.ebi.ac.uk/ena/data/view/X12713 EchoBASE EB1651 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1651 EcoGene EG11700 http://www.ecogene.org/geneInfo.php?eg_id=EG11700 EnsemblBacteria AAC73838 http://www.ensemblgenomes.org/id/AAC73838 EnsemblBacteria AAC73838 http://www.ensemblgenomes.org/id/AAC73838 EnsemblBacteria BAA35413 http://www.ensemblgenomes.org/id/BAA35413 EnsemblBacteria BAA35413 http://www.ensemblgenomes.org/id/BAA35413 EnsemblBacteria BAA35413 http://www.ensemblgenomes.org/id/BAA35413 EnsemblBacteria b0751 http://www.ensemblgenomes.org/id/b0751 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0034257 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034257 GO_process GO:0034258 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034258 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 945350 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945350 HOGENOM HOG000144393 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000144393&db=HOGENOM6 InParanoid P0AFK2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFK2 InterPro IPR006419 http://www.ebi.ac.uk/interpro/entry/IPR006419 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0734 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0734 KEGG_Gene eco:b0751 http://www.genome.jp/dbget-bin/www_bget?eco:b0751 KEGG_Orthology KO:K03811 http://www.genome.jp/dbget-bin/www_bget?KO:K03811 OMA GGYAMSW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GGYAMSW PSORT swissprot:PNUC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PNUC_ECOLI PSORT-B swissprot:PNUC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PNUC_ECOLI PSORT2 swissprot:PNUC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PNUC_ECOLI Pfam PF04973 http://pfam.xfam.org/family/PF04973 Phobius swissprot:PNUC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PNUC_ECOLI PhylomeDB P0AFK2 http://phylomedb.org/?seqid=P0AFK2 ProteinModelPortal P0AFK2 http://www.proteinmodelportal.org/query/uniprot/P0AFK2 PubMed 15561822 http://www.ncbi.nlm.nih.gov/pubmed/15561822 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2198247 http://www.ncbi.nlm.nih.gov/pubmed/2198247 PubMed 2841129 http://www.ncbi.nlm.nih.gov/pubmed/2841129 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415272 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415272 RefSeq WP_000345410 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000345410 STRING 511145.b0751 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0751&targetmode=cogs STRING COG3201 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3201&targetmode=cogs TIGRFAMs TIGR01528 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01528 UniProtKB PNUC_ECOLI http://www.uniprot.org/uniprot/PNUC_ECOLI UniProtKB-AC P0AFK2 http://www.uniprot.org/uniprot/P0AFK2 charge swissprot:PNUC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PNUC_ECOLI eggNOG COG3201 http://eggnogapi.embl.de/nog_data/html/tree/COG3201 eggNOG ENOG4106Z1T http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106Z1T epestfind swissprot:PNUC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PNUC_ECOLI garnier swissprot:PNUC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PNUC_ECOLI helixturnhelix swissprot:PNUC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PNUC_ECOLI hmoment swissprot:PNUC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PNUC_ECOLI iep swissprot:PNUC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PNUC_ECOLI inforesidue swissprot:PNUC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PNUC_ECOLI octanol swissprot:PNUC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PNUC_ECOLI pepcoil swissprot:PNUC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PNUC_ECOLI pepdigest swissprot:PNUC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PNUC_ECOLI pepinfo swissprot:PNUC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PNUC_ECOLI pepnet swissprot:PNUC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PNUC_ECOLI pepstats swissprot:PNUC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PNUC_ECOLI pepwheel swissprot:PNUC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PNUC_ECOLI pepwindow swissprot:PNUC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PNUC_ECOLI sigcleave swissprot:PNUC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PNUC_ECOLI ## Database ID URL or Descriptions # BioGrid 4262206 8 # DISRUPTION PHENOTYPE Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain. {ECO:0000269|PubMed 20345943}. # EcoGene EG11678 yadC # FUNCTION YADC_ECOLI Part of the yadCKLM-htrE-yadVN fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. {ECO 0000269|PubMed 20345943}. # GO_component GO:0009289 pilus; IEA:UniProtKB-SubCell. # GO_process GO:0006974 cellular response to DNA damage stimulus; IMP:EcoCyc. # GO_process GO:0043709 cell adhesion involved in single-species biofilm formation; IMP:EcoCyc. # GO_process GO:0046677 response to antibiotic; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0006950 response to stress # GOslim_process GO:0007155 cell adhesion # GOslim_process GO:0008150 biological_process # Gene3D 2.60.40.1090 -; 1. # INDUCTION Repressed by H-NS. {ECO:0000269|PubMed 20345943}. # InterPro IPR000259 Adhesion_dom_fimbrial # InterPro IPR008966 Adhesion_dom # InterPro IPR017014 Fimbrial-like_YadC # MISCELLANEOUS The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed. {ECO:0000305|PubMed 20345943}. # Organism YADC_ECOLI Escherichia coli (strain K12) # PATRIC 32115375 VBIEscCol129921_0139 # PIR G64736 G64736 # PIRSF PIRSF033053 UCP033503_fimbr # Pfam PF00419 Fimbrial # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YADC_ECOLI Uncharacterized fimbrial-like protein YadC # RefSeq NP_414677 NC_000913.3 # RefSeq WP_000848455 NZ_LN832404.1 # SIMILARITY Belongs to the fimbrial protein family. {ECO 0000305}. # SUBCELLULAR LOCATION YADC_ECOLI Fimbrium {ECO 0000305}. # SUPFAM SSF49401 SSF49401 # eggNOG ENOG4105P0Q Bacteria # eggNOG ENOG4111X8M LUCA BLAST swissprot:YADC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YADC_ECOLI BioCyc ECOL316407:JW0131-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0131-MONOMER BioCyc EcoCyc:EG11678-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11678-MONOMER DIP DIP-11181N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11181N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1111/j.1462-2920.2010.02202.x http://dx.doi.org/10.1111/j.1462-2920.2010.02202.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L17086 http://www.ebi.ac.uk/ena/data/view/L17086 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X65538 http://www.ebi.ac.uk/ena/data/view/X65538 EchoBASE EB1629 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1629 EcoGene EG11678 http://www.ecogene.org/geneInfo.php?eg_id=EG11678 EnsemblBacteria AAC73246 http://www.ensemblgenomes.org/id/AAC73246 EnsemblBacteria AAC73246 http://www.ensemblgenomes.org/id/AAC73246 EnsemblBacteria BAB96712 http://www.ensemblgenomes.org/id/BAB96712 EnsemblBacteria BAB96712 http://www.ensemblgenomes.org/id/BAB96712 EnsemblBacteria BAB96712 http://www.ensemblgenomes.org/id/BAB96712 EnsemblBacteria b0135 http://www.ensemblgenomes.org/id/b0135 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009289 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0043709 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043709 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 2.60.40.1090 http://www.cathdb.info/version/latest/superfamily/2.60.40.1090 GeneID 944837 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944837 HOGENOM HOG000116867 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000116867&db=HOGENOM6 InterPro IPR000259 http://www.ebi.ac.uk/interpro/entry/IPR000259 InterPro IPR008966 http://www.ebi.ac.uk/interpro/entry/IPR008966 InterPro IPR017014 http://www.ebi.ac.uk/interpro/entry/IPR017014 KEGG_Gene ecj:JW0131 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0131 KEGG_Gene eco:b0135 http://www.genome.jp/dbget-bin/www_bget?eco:b0135 OMA ANTINRK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ANTINRK PSORT swissprot:YADC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YADC_ECOLI PSORT-B swissprot:YADC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YADC_ECOLI PSORT2 swissprot:YADC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YADC_ECOLI Pfam PF00419 http://pfam.xfam.org/family/PF00419 Phobius swissprot:YADC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YADC_ECOLI ProteinModelPortal P31058 http://www.proteinmodelportal.org/query/uniprot/P31058 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20345943 http://www.ncbi.nlm.nih.gov/pubmed/20345943 PubMed 8096212 http://www.ncbi.nlm.nih.gov/pubmed/8096212 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414677 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414677 RefSeq WP_000848455 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000848455 SMR P31058 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31058 STRING 511145.b0135 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0135&targetmode=cogs SUPFAM SSF49401 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49401 UniProtKB YADC_ECOLI http://www.uniprot.org/uniprot/YADC_ECOLI UniProtKB-AC P31058 http://www.uniprot.org/uniprot/P31058 charge swissprot:YADC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YADC_ECOLI eggNOG ENOG4105P0Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105P0Q eggNOG ENOG4111X8M http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111X8M epestfind swissprot:YADC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YADC_ECOLI garnier swissprot:YADC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YADC_ECOLI helixturnhelix swissprot:YADC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YADC_ECOLI hmoment swissprot:YADC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YADC_ECOLI iep swissprot:YADC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YADC_ECOLI inforesidue swissprot:YADC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YADC_ECOLI octanol swissprot:YADC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YADC_ECOLI pepcoil swissprot:YADC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YADC_ECOLI pepdigest swissprot:YADC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YADC_ECOLI pepinfo swissprot:YADC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YADC_ECOLI pepnet swissprot:YADC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YADC_ECOLI pepstats swissprot:YADC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YADC_ECOLI pepwheel swissprot:YADC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YADC_ECOLI pepwindow swissprot:YADC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YADC_ECOLI sigcleave swissprot:YADC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YADC_ECOLI ## Database ID URL or Descriptions # AltName NHAA_ECOLI Sodium/proton antiporter NhaA # BioGrid 4259720 28 # EcoGene EG10652 nhaA # FUNCTION NHAA_ECOLI Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. Catalyzes the exchange of 2 H(+) per Na(+). Can mediate sodium uptake when a transmembrane pH gradient is applied. Active at alkaline pH. Activity is strongly down- regulated below pH 6.5. {ECO 0000269|PubMed 1645730}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015081 sodium ion transmembrane transporter activity; IEA:UniProtKB-HAMAP. # GO_function NHAA_ECOLI GO 0015491 cation cation antiporter activity; IDA EcoCyc. # GO_process GO:0006814 sodium ion transport; IDA:EcoCyc. # GO_process GO:0006885 regulation of pH; IEA:InterPro. # GO_process GO:0015992 proton transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0042592 homeostatic process # Gene3D 1.20.1530.10 -; 1. # HAMAP MF_01844 NhaA # INDUCTION NHAA_ECOLI Transcription stimulated by high Na(+) concentrations. # InterPro IPR004670 NhaA # InterPro IPR023171 Na/H_antiporter_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko00680 Methane metabolism # Organism NHAA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30341:SF0 PTHR30341:SF0 # PATRIC 32115129 VBIEscCol129921_0016 # PDB 1ZCD X-ray; 3.45 A; A/B=1-388 # PDB 3FI1 EM; 7.00 A; A=9-384 # PDB 4ATV X-ray; 3.50 A; A/B/C/D=1-388 # PDB 4AU5 X-ray; 3.70 A; A/B/C/D=1-388 # PIR C64722 C64722 # Pfam PF06965 Na_H_antiport_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NHAA_ECOLI Na(+)/H(+) antiporter NhaA # RefSeq NP_414560 NC_000913.3 # RefSeq WP_000681354 NZ_LN832404.1 # SIMILARITY Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family. {ECO 0000305}. # SUBCELLULAR LOCATION NHAA_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT NHAA_ECOLI Monomer and homodimer. {ECO 0000269|PubMed 11258962, ECO 0000269|PubMed 17635927}. # TCDB 2.A.33.1:the nhaa na(+) h(+) antiporter (nhaa) family # TIGRFAMs TIGR00773 NhaA # eggNOG COG3004 LUCA # eggNOG ENOG4105DRC Bacteria BLAST swissprot:NHAA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NHAA_ECOLI BioCyc ECOL316407:JW0018-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0018-MONOMER BioCyc EcoCyc:NHAA-MONOMER http://biocyc.org/getid?id=EcoCyc:NHAA-MONOMER BioCyc MetaCyc:NHAA-MONOMER http://biocyc.org/getid?id=MetaCyc:NHAA-MONOMER COG COG3004 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3004 DIP DIP-10335N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10335N DOI 10.1016/0014-5793(95)00331-3 http://dx.doi.org/10.1016/0014-5793(95)00331-3 DOI 10.1021/bi002669o http://dx.doi.org/10.1021/bi002669o DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature03692 http://dx.doi.org/10.1038/nature03692 DOI 10.1073/pnas.90.4.1212 http://dx.doi.org/10.1073/pnas.90.4.1212 DOI 10.1074/jbc.270.45.26813 http://dx.doi.org/10.1074/jbc.270.45.26813 DOI 10.1074/jbc.M704469200 http://dx.doi.org/10.1074/jbc.M704469200 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J03879 http://www.ebi.ac.uk/ena/data/view/J03879 EMBL S67239 http://www.ebi.ac.uk/ena/data/view/S67239 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0646 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0646 EcoGene EG10652 http://www.ecogene.org/geneInfo.php?eg_id=EG10652 EnsemblBacteria AAC73130 http://www.ensemblgenomes.org/id/AAC73130 EnsemblBacteria AAC73130 http://www.ensemblgenomes.org/id/AAC73130 EnsemblBacteria BAB96592 http://www.ensemblgenomes.org/id/BAB96592 EnsemblBacteria BAB96592 http://www.ensemblgenomes.org/id/BAB96592 EnsemblBacteria BAB96592 http://www.ensemblgenomes.org/id/BAB96592 EnsemblBacteria b0019 http://www.ensemblgenomes.org/id/b0019 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015081 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015081 GO_function GO:0015491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015491 GO_process GO:0006814 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814 GO_process GO:0006885 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006885 GO_process GO:0015992 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015992 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 Gene3D 1.20.1530.10 http://www.cathdb.info/version/latest/superfamily/1.20.1530.10 GeneID 944758 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944758 HAMAP MF_01844 http://hamap.expasy.org/unirule/MF_01844 HOGENOM HOG000218489 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218489&db=HOGENOM6 InParanoid P13738 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P13738 InterPro IPR004670 http://www.ebi.ac.uk/interpro/entry/IPR004670 InterPro IPR023171 http://www.ebi.ac.uk/interpro/entry/IPR023171 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW0018 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0018 KEGG_Gene eco:b0019 http://www.genome.jp/dbget-bin/www_bget?eco:b0019 KEGG_Orthology KO:K03313 http://www.genome.jp/dbget-bin/www_bget?KO:K03313 KEGG_Pathway ko00680 http://www.genome.jp/kegg-bin/show_pathway?ko00680 OMA QKAIFPA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QKAIFPA PANTHER PTHR30341:SF0 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30341:SF0 PDB 1ZCD http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZCD PDB 3FI1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3FI1 PDB 4ATV http://www.ebi.ac.uk/pdbe-srv/view/entry/4ATV PDB 4AU5 http://www.ebi.ac.uk/pdbe-srv/view/entry/4AU5 PDBsum 1ZCD http://www.ebi.ac.uk/pdbsum/1ZCD PDBsum 3FI1 http://www.ebi.ac.uk/pdbsum/3FI1 PDBsum 4ATV http://www.ebi.ac.uk/pdbsum/4ATV PDBsum 4AU5 http://www.ebi.ac.uk/pdbsum/4AU5 PSORT swissprot:NHAA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NHAA_ECOLI PSORT-B swissprot:NHAA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NHAA_ECOLI PSORT2 swissprot:NHAA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NHAA_ECOLI Pfam PF06965 http://pfam.xfam.org/family/PF06965 Phobius swissprot:NHAA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NHAA_ECOLI PhylomeDB P13738 http://phylomedb.org/?seqid=P13738 ProteinModelPortal P13738 http://www.proteinmodelportal.org/query/uniprot/P13738 PubMed 11258962 http://www.ncbi.nlm.nih.gov/pubmed/11258962 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 15988517 http://www.ncbi.nlm.nih.gov/pubmed/15988517 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 1645730 http://www.ncbi.nlm.nih.gov/pubmed/1645730 PubMed 1657980 http://www.ncbi.nlm.nih.gov/pubmed/1657980 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17635927 http://www.ncbi.nlm.nih.gov/pubmed/17635927 PubMed 2839489 http://www.ncbi.nlm.nih.gov/pubmed/2839489 PubMed 7592922 http://www.ncbi.nlm.nih.gov/pubmed/7592922 PubMed 7737413 http://www.ncbi.nlm.nih.gov/pubmed/7737413 PubMed 8381959 http://www.ncbi.nlm.nih.gov/pubmed/8381959 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414560 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414560 RefSeq WP_000681354 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000681354 SMR P13738 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P13738 STRING 511145.b0019 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0019&targetmode=cogs STRING COG3004 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3004&targetmode=cogs TCDB 2.A.33.1 http://www.tcdb.org/search/result.php?tc=2.A.33.1 TIGRFAMs TIGR00773 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00773 UniProtKB NHAA_ECOLI http://www.uniprot.org/uniprot/NHAA_ECOLI UniProtKB-AC P13738 http://www.uniprot.org/uniprot/P13738 charge swissprot:NHAA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NHAA_ECOLI eggNOG COG3004 http://eggnogapi.embl.de/nog_data/html/tree/COG3004 eggNOG ENOG4105DRC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DRC epestfind swissprot:NHAA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NHAA_ECOLI garnier swissprot:NHAA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NHAA_ECOLI helixturnhelix swissprot:NHAA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NHAA_ECOLI hmoment swissprot:NHAA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NHAA_ECOLI iep swissprot:NHAA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NHAA_ECOLI inforesidue swissprot:NHAA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NHAA_ECOLI octanol swissprot:NHAA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NHAA_ECOLI pepcoil swissprot:NHAA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NHAA_ECOLI pepdigest swissprot:NHAA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NHAA_ECOLI pepinfo swissprot:NHAA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NHAA_ECOLI pepnet swissprot:NHAA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NHAA_ECOLI pepstats swissprot:NHAA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NHAA_ECOLI pepwheel swissprot:NHAA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NHAA_ECOLI pepwindow swissprot:NHAA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NHAA_ECOLI sigcleave swissprot:NHAA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NHAA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260610 41 # EcoGene EG12857 yfiM # IntAct P46126 2 # InterPro IPR017028 UCP034456 # InterPro IPR018736 DUF2279_periplasmic_lipo # Organism YFIM_ECOLI Escherichia coli (strain K12) # PATRIC 32120573 VBIEscCol129921_2689 # PIR A65037 A65037 # PIRSF PIRSF034456 UCP034456 # Pfam PF10043 DUF2279 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFIM_ECOLI Uncharacterized protein YfiM # RefSeq NP_417081 NC_000913.3 # SEQUENCE CAUTION Sequence=BAA16471.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=M58699; Type=Miscellaneous discrepancy; Note=Several sequencing errors.; Evidence={ECO 0000305}; # eggNOG COG5544 LUCA # eggNOG ENOG4105T42 Bacteria BLAST swissprot:YFIM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFIM_ECOLI BioCyc ECOL316407:JW2570-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2570-MONOMER BioCyc EcoCyc:EG12857-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12857-MONOMER COG COG5544 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG5544 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M58699 http://www.ebi.ac.uk/ena/data/view/M58699 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X53027 http://www.ebi.ac.uk/ena/data/view/X53027 EMBL X75467 http://www.ebi.ac.uk/ena/data/view/X75467 EchoBASE EB2700 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2700 EcoGene EG12857 http://www.ecogene.org/geneInfo.php?eg_id=EG12857 EnsemblBacteria AAC75639 http://www.ensemblgenomes.org/id/AAC75639 EnsemblBacteria AAC75639 http://www.ensemblgenomes.org/id/AAC75639 EnsemblBacteria BAA16471 http://www.ensemblgenomes.org/id/BAA16471 EnsemblBacteria BAA16471 http://www.ensemblgenomes.org/id/BAA16471 EnsemblBacteria BAA16471 http://www.ensemblgenomes.org/id/BAA16471 EnsemblBacteria b2586 http://www.ensemblgenomes.org/id/b2586 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947060 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947060 HOGENOM HOG000123535 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000123535&db=HOGENOM6 InParanoid P46126 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P46126 IntAct P46126 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P46126* InterPro IPR017028 http://www.ebi.ac.uk/interpro/entry/IPR017028 InterPro IPR018736 http://www.ebi.ac.uk/interpro/entry/IPR018736 KEGG_Gene ecj:JW2570 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2570 KEGG_Gene eco:b2586 http://www.genome.jp/dbget-bin/www_bget?eco:b2586 KEGG_Orthology KO:K05811 http://www.genome.jp/dbget-bin/www_bget?KO:K05811 OMA YDSREGG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YDSREGG PSORT swissprot:YFIM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFIM_ECOLI PSORT-B swissprot:YFIM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFIM_ECOLI PSORT2 swissprot:YFIM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFIM_ECOLI Pfam PF10043 http://pfam.xfam.org/family/PF10043 Phobius swissprot:YFIM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFIM_ECOLI ProteinModelPortal P46126 http://www.proteinmodelportal.org/query/uniprot/P46126 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2002065 http://www.ncbi.nlm.nih.gov/pubmed/2002065 PubMed 2118499 http://www.ncbi.nlm.nih.gov/pubmed/2118499 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417081 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417081 STRING 511145.b2586 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2586&targetmode=cogs STRING COG5544 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG5544&targetmode=cogs UniProtKB YFIM_ECOLI http://www.uniprot.org/uniprot/YFIM_ECOLI UniProtKB-AC P46126 http://www.uniprot.org/uniprot/P46126 charge swissprot:YFIM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFIM_ECOLI eggNOG COG5544 http://eggnogapi.embl.de/nog_data/html/tree/COG5544 eggNOG ENOG4105T42 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105T42 epestfind swissprot:YFIM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFIM_ECOLI garnier swissprot:YFIM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFIM_ECOLI helixturnhelix swissprot:YFIM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFIM_ECOLI hmoment swissprot:YFIM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFIM_ECOLI iep swissprot:YFIM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFIM_ECOLI inforesidue swissprot:YFIM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFIM_ECOLI octanol swissprot:YFIM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFIM_ECOLI pepcoil swissprot:YFIM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFIM_ECOLI pepdigest swissprot:YFIM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFIM_ECOLI pepinfo swissprot:YFIM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFIM_ECOLI pepnet swissprot:YFIM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFIM_ECOLI pepstats swissprot:YFIM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFIM_ECOLI pepwheel swissprot:YFIM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFIM_ECOLI pepwindow swissprot:YFIM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFIM_ECOLI sigcleave swissprot:YFIM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFIM_ECOLI ## Database ID URL or Descriptions # AltName FHUA_ECOLI Ferric hydroxamate receptor # AltName FHUA_ECOLI Ferric hydroxamate uptake # BioGrid 4259745 124 # EcoGene EG10302 fhuA # FUNCTION FHUA_ECOLI This receptor binds the ferrichrome-iron ligand. It interacts with the TonB protein, which is responsible for energy coupling of the ferrichrome-promoted iron transport system. Acts as a receptor for bacteriophage T5 as well as T1, phi80 and colicin M. Binding of T5 triggers the opening of a high conductance ion channel. Can also transport the antibiotic albomycin. {ECO 0000269|PubMed 8617231}. # GO_component GO:0009279 cell outer membrane; IMP:CACAO. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0004872 receptor activity; IEA:InterPro. # GO_function GO:0005506 iron ion binding; IPI:EcoliWiki. # GO_function GO:0015344 siderophore uptake transmembrane transporter activity; IBA:GO_Central. # GO_function GO:0015643 toxic substance binding; IMP:EcoliWiki. # GO_function GO:0046790 virion binding; IMP:EcoliWiki. # GO_function GO:0048037 cofactor binding; IPI:EcoliWiki. # GO_process GO:0055072 iron ion homeostasis; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0042592 homeostatic process # Gene3D 2.170.130.10 -; 1. # Gene3D 2.40.170.20 -; 1. # INDUCTION Induced 1.6-fold by hydroxyurea. {ECO:0000269|PubMed 20005847}. # IntAct P06971 5 # InterPro IPR000531 TonB-dep_rcpt_b-brl # InterPro IPR010105 TonB_sidphr_rcpt # InterPro IPR010916 TonB_box_CS # InterPro IPR010917 TonB_rcpt_CS # InterPro IPR012910 Plug_dom # KEGG_Brite ko02000 Transporters # Organism FHUA_ECOLI Escherichia coli (strain K12) # PATRIC 32115409 VBIEscCol129921_0156 # PDB 1BY3 X-ray; 2.74 A; A=34-747 # PDB 1BY5 X-ray; 2.60 A; A=34-747 # PDB 1FCP X-ray; 2.70 A; A=52-747 # PDB 1FI1 X-ray; 2.90 A; A=52-747 # PDB 1QFF X-ray; 2.70 A; A=34-747 # PDB 1QFG X-ray; 2.50 A; A=34-747 # PDB 1QJQ X-ray; 2.95 A; A=34-747 # PDB 1QKC X-ray; 3.10 A; A=34-747 # PDB 2FCP X-ray; 2.50 A; A=34-747 # PDB 2GRX X-ray; 3.30 A; A/B=34-747 # PIR F64738 QRECFE # PROSITE PS00430 TONB_DEPENDENT_REC_1 # PROSITE PS01156 TONB_DEPENDENT_REC_2 # Pfam PF00593 TonB_dep_Rec # Pfam PF07715 Plug # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FHUA_ECOLI Ferrichrome-iron receptor # RefSeq NP_414692 NC_000913.3 # RefSeq WP_000124438 NZ_LN832404.1 # SIMILARITY Belongs to the TonB-dependent receptor family. {ECO 0000305}. # SUBCELLULAR LOCATION FHUA_ECOLI Cell outer membrane; Multi-pass membrane protein. # SUBUNIT FHUA_ECOLI Monomer. # TCDB 1.B.14.1 the outer membrane receptor (omr) family # TIGRFAMs TIGR01783 TonB-siderophor # eggNOG COG1629 LUCA # eggNOG ENOG4105E0K Bacteria BLAST swissprot:FHUA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FHUA_ECOLI BioCyc ECOL316407:JW0146-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0146-MONOMER BioCyc EcoCyc:EG10302-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10302-MONOMER BioCyc MetaCyc:EG10302-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10302-MONOMER COG COG1629 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1629 DIP DIP-9602N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9602N DOI 10.1007/BF00329835 http://dx.doi.org/10.1007/BF00329835 DOI 10.1016/0014-5793(94)00431-5 http://dx.doi.org/10.1016/0014-5793(94)00431-5 DOI 10.1016/S0092-8674(00)81700-6 http://dx.doi.org/10.1016/S0092-8674(00)81700-6 DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1110/ps.9.5.956 http://dx.doi.org/10.1110/ps.9.5.956 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1126/science.282.5397.2215 http://dx.doi.org/10.1126/science.282.5397.2215 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M12486 http://www.ebi.ac.uk/ena/data/view/M12486 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EMBL X05810 http://www.ebi.ac.uk/ena/data/view/X05810 EchoBASE EB0298 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0298 EcoGene EG10302 http://www.ecogene.org/geneInfo.php?eg_id=EG10302 EnsemblBacteria AAC73261 http://www.ensemblgenomes.org/id/AAC73261 EnsemblBacteria AAC73261 http://www.ensemblgenomes.org/id/AAC73261 EnsemblBacteria BAB96726 http://www.ensemblgenomes.org/id/BAB96726 EnsemblBacteria BAB96726 http://www.ensemblgenomes.org/id/BAB96726 EnsemblBacteria BAB96726 http://www.ensemblgenomes.org/id/BAB96726 EnsemblBacteria b0150 http://www.ensemblgenomes.org/id/b0150 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0004872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004872 GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0015344 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015344 GO_function GO:0015643 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015643 GO_function GO:0046790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046790 GO_function GO:0048037 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048037 GO_process GO:0055072 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055072 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 Gene3D 2.170.130.10 http://www.cathdb.info/version/latest/superfamily/2.170.130.10 Gene3D 2.40.170.20 http://www.cathdb.info/version/latest/superfamily/2.40.170.20 GeneID 944856 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944856 HOGENOM HOG000260252 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260252&db=HOGENOM6 InParanoid P06971 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P06971 IntAct P06971 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P06971* InterPro IPR000531 http://www.ebi.ac.uk/interpro/entry/IPR000531 InterPro IPR010105 http://www.ebi.ac.uk/interpro/entry/IPR010105 InterPro IPR010916 http://www.ebi.ac.uk/interpro/entry/IPR010916 InterPro IPR010917 http://www.ebi.ac.uk/interpro/entry/IPR010917 InterPro IPR012910 http://www.ebi.ac.uk/interpro/entry/IPR012910 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0146 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0146 KEGG_Gene eco:b0150 http://www.genome.jp/dbget-bin/www_bget?eco:b0150 KEGG_Orthology KO:K02014 http://www.genome.jp/dbget-bin/www_bget?KO:K02014 OMA TVRENSY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TVRENSY PDB 1BY3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1BY3 PDB 1BY5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1BY5 PDB 1FCP http://www.ebi.ac.uk/pdbe-srv/view/entry/1FCP PDB 1FI1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1FI1 PDB 1QFF http://www.ebi.ac.uk/pdbe-srv/view/entry/1QFF PDB 1QFG http://www.ebi.ac.uk/pdbe-srv/view/entry/1QFG PDB 1QJQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1QJQ PDB 1QKC http://www.ebi.ac.uk/pdbe-srv/view/entry/1QKC PDB 2FCP http://www.ebi.ac.uk/pdbe-srv/view/entry/2FCP PDB 2GRX http://www.ebi.ac.uk/pdbe-srv/view/entry/2GRX PDBsum 1BY3 http://www.ebi.ac.uk/pdbsum/1BY3 PDBsum 1BY5 http://www.ebi.ac.uk/pdbsum/1BY5 PDBsum 1FCP http://www.ebi.ac.uk/pdbsum/1FCP PDBsum 1FI1 http://www.ebi.ac.uk/pdbsum/1FI1 PDBsum 1QFF http://www.ebi.ac.uk/pdbsum/1QFF PDBsum 1QFG http://www.ebi.ac.uk/pdbsum/1QFG PDBsum 1QJQ http://www.ebi.ac.uk/pdbsum/1QJQ PDBsum 1QKC http://www.ebi.ac.uk/pdbsum/1QKC PDBsum 2FCP http://www.ebi.ac.uk/pdbsum/2FCP PDBsum 2GRX http://www.ebi.ac.uk/pdbsum/2GRX PROSITE PS00430 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00430 PROSITE PS01156 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01156 PSORT swissprot:FHUA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FHUA_ECOLI PSORT-B swissprot:FHUA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FHUA_ECOLI PSORT2 swissprot:FHUA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FHUA_ECOLI Pfam PF00593 http://pfam.xfam.org/family/PF00593 Pfam PF07715 http://pfam.xfam.org/family/PF07715 Phobius swissprot:FHUA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FHUA_ECOLI PhylomeDB P06971 http://phylomedb.org/?seqid=P06971 ProteinModelPortal P06971 http://www.proteinmodelportal.org/query/uniprot/P06971 PubMed 10850805 http://www.ncbi.nlm.nih.gov/pubmed/10850805 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 2823072 http://www.ncbi.nlm.nih.gov/pubmed/2823072 PubMed 3079747 http://www.ncbi.nlm.nih.gov/pubmed/3079747 PubMed 7515827 http://www.ncbi.nlm.nih.gov/pubmed/7515827 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 8617231 http://www.ncbi.nlm.nih.gov/pubmed/8617231 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9856937 http://www.ncbi.nlm.nih.gov/pubmed/9856937 PubMed 9865695 http://www.ncbi.nlm.nih.gov/pubmed/9865695 RefSeq NP_414692 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414692 RefSeq WP_000124438 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000124438 SMR P06971 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P06971 STRING 511145.b0150 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0150&targetmode=cogs STRING COG1629 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1629&targetmode=cogs TCDB 1.B.14.1 http://www.tcdb.org/search/result.php?tc=1.B.14.1 TIGRFAMs TIGR01783 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01783 UniProtKB FHUA_ECOLI http://www.uniprot.org/uniprot/FHUA_ECOLI UniProtKB-AC P06971 http://www.uniprot.org/uniprot/P06971 charge swissprot:FHUA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FHUA_ECOLI eggNOG COG1629 http://eggnogapi.embl.de/nog_data/html/tree/COG1629 eggNOG ENOG4105E0K http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E0K epestfind swissprot:FHUA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FHUA_ECOLI garnier swissprot:FHUA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FHUA_ECOLI helixturnhelix swissprot:FHUA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FHUA_ECOLI hmoment swissprot:FHUA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FHUA_ECOLI iep swissprot:FHUA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FHUA_ECOLI inforesidue swissprot:FHUA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FHUA_ECOLI octanol swissprot:FHUA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FHUA_ECOLI pepcoil swissprot:FHUA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FHUA_ECOLI pepdigest swissprot:FHUA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FHUA_ECOLI pepinfo swissprot:FHUA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FHUA_ECOLI pepnet swissprot:FHUA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FHUA_ECOLI pepstats swissprot:FHUA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FHUA_ECOLI pepwheel swissprot:FHUA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FHUA_ECOLI pepwindow swissprot:FHUA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FHUA_ECOLI sigcleave swissprot:FHUA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FHUA_ECOLI ## Database ID URL or Descriptions # AltName FLID_ECOLI Filament cap protein # AltName FLID_ECOLI Flagellar cap protein # BioGrid 4260370 8 # EcoGene EG10841 fliD # FUNCTION FLID_ECOLI Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end. # GO_component GO:0005576 extracellular region; IEA:UniProtKB-SubCell. # GO_component GO:0009421 bacterial-type flagellum filament cap; IBA:GO_Central. # GO_component GO:0009424 bacterial-type flagellum hook; IEA:InterPro. # GO_process GO:0007155 cell adhesion; IEA:InterPro. # GO_process GO:0071973 bacterial-type flagellum-dependent cell motility; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005576 extracellular region # GOslim_process GO:0007155 cell adhesion # GOslim_process GO:0048870 cell motility # INTERACTION FLID_ECOLI P0ABY2 fliT; NbExp=4; IntAct=EBI-1126352, EBI-1114780; # IntAct P24216 8 # InterPro IPR003481 FliD_N # InterPro IPR010809 FliD_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Pathway ko02040 Flagellar assembly # Organism FLID_ECOLI Escherichia coli (strain K12) # PATRIC 32119183 VBIEscCol129921_2006 # PIR A64956 A64956 # Pfam PF02465 FliD_N # Pfam PF07195 FliD_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FLID_ECOLI Flagellar hook-associated protein 2 # RefSeq NP_416434 NC_000913.3 # RefSeq WP_000146784 NZ_LN832404.1 # SIMILARITY Belongs to the FliD family. {ECO 0000305}. # SUBCELLULAR LOCATION FLID_ECOLI Secreted. Bacterial flagellum. # SUBUNIT Homopentamer. {ECO 0000305}. # eggNOG COG1345 LUCA # eggNOG ENOG4105DTS Bacteria BLAST swissprot:FLID_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLID_ECOLI BioCyc ECOL316407:JW1909-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1909-MONOMER BioCyc EcoCyc:EG10841-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10841-MONOMER COG COG1345 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1345 DOI 10.1007/BF00332229 http://dx.doi.org/10.1007/BF00332229 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1099/00221287-138-6-1051 http://dx.doi.org/10.1099/00221287-138-6-1051 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01607 http://www.ebi.ac.uk/ena/data/view/J01607 EMBL M85240 http://www.ebi.ac.uk/ena/data/view/M85240 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X17440 http://www.ebi.ac.uk/ena/data/view/X17440 EchoBASE EB0834 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0834 EcoGene EG10841 http://www.ecogene.org/geneInfo.php?eg_id=EG10841 EnsemblBacteria AAC74991 http://www.ensemblgenomes.org/id/AAC74991 EnsemblBacteria AAC74991 http://www.ensemblgenomes.org/id/AAC74991 EnsemblBacteria BAA15752 http://www.ensemblgenomes.org/id/BAA15752 EnsemblBacteria BAA15752 http://www.ensemblgenomes.org/id/BAA15752 EnsemblBacteria BAA15752 http://www.ensemblgenomes.org/id/BAA15752 EnsemblBacteria b1924 http://www.ensemblgenomes.org/id/b1924 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005576 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576 GO_component GO:0009421 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009421 GO_component GO:0009424 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009424 GO_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GO_process GO:0071973 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071973 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005576 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 GeneID 946428 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946428 HOGENOM HOG000254632 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000254632&db=HOGENOM6 InParanoid P24216 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P24216 IntAct P24216 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P24216* InterPro IPR003481 http://www.ebi.ac.uk/interpro/entry/IPR003481 InterPro IPR010809 http://www.ebi.ac.uk/interpro/entry/IPR010809 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW1909 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1909 KEGG_Gene eco:b1924 http://www.genome.jp/dbget-bin/www_bget?eco:b1924 KEGG_Orthology KO:K02407 http://www.genome.jp/dbget-bin/www_bget?KO:K02407 KEGG_Pathway ko02040 http://www.genome.jp/kegg-bin/show_pathway?ko02040 OMA QEAYTEV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QEAYTEV PSORT swissprot:FLID_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLID_ECOLI PSORT-B swissprot:FLID_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLID_ECOLI PSORT2 swissprot:FLID_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLID_ECOLI Pfam PF02465 http://pfam.xfam.org/family/PF02465 Pfam PF07195 http://pfam.xfam.org/family/PF07195 Phobius swissprot:FLID_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLID_ECOLI PhylomeDB P24216 http://phylomedb.org/?seqid=P24216 ProteinModelPortal P24216 http://www.proteinmodelportal.org/query/uniprot/P24216 PubMed 1527488 http://www.ncbi.nlm.nih.gov/pubmed/1527488 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2659972 http://www.ncbi.nlm.nih.gov/pubmed/2659972 PubMed 6305924 http://www.ncbi.nlm.nih.gov/pubmed/6305924 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416434 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416434 RefSeq WP_000146784 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000146784 SMR P24216 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P24216 STRING 511145.b1924 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1924&targetmode=cogs STRING COG1345 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1345&targetmode=cogs SWISS-2DPAGE P24216 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P24216 UniProtKB FLID_ECOLI http://www.uniprot.org/uniprot/FLID_ECOLI UniProtKB-AC P24216 http://www.uniprot.org/uniprot/P24216 charge swissprot:FLID_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLID_ECOLI eggNOG COG1345 http://eggnogapi.embl.de/nog_data/html/tree/COG1345 eggNOG ENOG4105DTS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DTS epestfind swissprot:FLID_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLID_ECOLI garnier swissprot:FLID_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLID_ECOLI helixturnhelix swissprot:FLID_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLID_ECOLI hmoment swissprot:FLID_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLID_ECOLI iep swissprot:FLID_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLID_ECOLI inforesidue swissprot:FLID_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLID_ECOLI octanol swissprot:FLID_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLID_ECOLI pepcoil swissprot:FLID_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLID_ECOLI pepdigest swissprot:FLID_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLID_ECOLI pepinfo swissprot:FLID_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLID_ECOLI pepnet swissprot:FLID_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLID_ECOLI pepstats swissprot:FLID_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLID_ECOLI pepwheel swissprot:FLID_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLID_ECOLI pepwindow swissprot:FLID_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLID_ECOLI sigcleave swissprot:FLID_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLID_ECOLI ## Database ID URL or Descriptions # AltName IDI_ECOLI Isopentenyl pyrophosphate isomerase # AltName IPP DMAPP isomerase # BIOPHYSICOCHEMICAL PROPERTIES IDI_ECOLI Kinetic parameters KM=9.5 uM for Isopentenyl diphosphate {ECO 0000269|PubMed 16617181}; Vmax=260 mmol/h/mg enzyme {ECO 0000269|PubMed 16617181}; # BRENDA 5.3.3 2026 # BioGrid 4259434 130 # CATALYTIC ACTIVITY IDI_ECOLI Isopentenyl diphosphate = dimethylallyl diphosphate. # CDD cd02885 IPP_Isomerase # COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI 18420; Note=Binds 1 Mg(2+) ion per subunit. The magnesium ion binds only when substrate is bound.; # COFACTOR Name=Mn(2+); Xref=ChEBI:CHEBI 29035; Note=Binds 1 Mn(2+) ion per subunit.; # EcoGene EG13072 idi # FUNCTION IDI_ECOLI Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). {ECO 0000269|PubMed 10099534, ECO 0000269|PubMed 9603997}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0004452 isopentenyl-diphosphate delta-isomerase activity; IDA:EcoCyc. # GO_function GO:0016787 hydrolase activity; IEA:InterPro. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0008299 isoprenoid biosynthetic process; IMP:EcoCyc. # GO_process GO:0050992 dimethylallyl diphosphate biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.90.79.10 -; 1. # HAMAP MF_00202 Idi # IntAct Q46822 4 # InterPro IPR000086 NUDIX_hydrolase_dom # InterPro IPR011876 IsopentenylPP_isomerase_typ1 # InterPro IPR015797 NUDIX_hydrolase_dom-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00900 Terpenoid backbone biosynthesis # Organism IDI_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10885 PTHR10885 # PATHWAY Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate step 1/1. # PATRIC 32121188 VBIEscCol129921_2982 # PDB 1HX3 X-ray; 2.10 A; A/B=1-182 # PDB 1HZT X-ray; 1.45 A; A=1-182 # PDB 1I9A X-ray; 2.50 A; A/B=1-182 # PDB 1NFS X-ray; 1.96 A; A/B=1-182 # PDB 1NFZ X-ray; 1.97 A; A/B=1-182 # PDB 1OW2 X-ray; 2.00 A; A/B=1-182 # PDB 1PPV X-ray; 1.70 A; A/B=1-182 # PDB 1PPW X-ray; 2.21 A; A/B=1-182 # PDB 1PVF X-ray; 1.78 A; A/B=1-182 # PDB 1Q54 X-ray; 1.93 A; A/B=1-182 # PDB 1R67 X-ray; 1.77 A; A=1-182 # PDB 1X83 X-ray; 1.80 A; A/B=1-182 # PDB 1X84 X-ray; 1.78 A; A/B=1-182 # PDB 2B2K X-ray; 1.97 A; A/B=1-182 # PDB 2G73 X-ray; 1.97 A; A/B=1-182 # PDB 2G74 X-ray; 1.96 A; A/B=1-182 # PDB 2VNP X-ray; 2.19 A; A/B=1-182 # PDB 2VNQ X-ray; 2.20 A; A/B=1-182 # PIR A65073 A65073 # PIRSF PIRSF018427 Isopntndiph_ism # PROSITE PS51462 NUDIX # Pfam PF00293 NUDIX # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName IDI_ECOLI Isopentenyl-diphosphate Delta-isomerase # RefSeq NP_417365 NC_000913.3 # RefSeq WP_001192820 NZ_LN832404.1 # SIMILARITY Belongs to the IPP isomerase type 1 family. {ECO 0000305}. # SIMILARITY Contains 1 nudix hydrolase domain. {ECO 0000305}. # SUBCELLULAR LOCATION IDI_ECOLI Cytoplasm. # SUBUNIT IDI_ECOLI Homodimer. {ECO 0000269|PubMed 11285217, ECO 0000269|PubMed 11698677, ECO 0000269|PubMed 12540835, ECO 0000269|PubMed 12630859, ECO 0000269|PubMed 14696183, ECO 0000269|PubMed 15643873, ECO 0000269|PubMed 16617181}. # SUPFAM SSF55811 SSF55811 # TIGRFAMs TIGR02150 IPP_isom_1 # UniPathway UPA00059 UER00104 # eggNOG COG1443 LUCA # eggNOG ENOG4108ZEY Bacteria BLAST swissprot:IDI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:IDI_ECOLI BioCyc ECOL316407:JW2857-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2857-MONOMER BioCyc EcoCyc:IPPISOM-MONOMER http://biocyc.org/getid?id=EcoCyc:IPPISOM-MONOMER BioCyc MetaCyc:IPPISOM-MONOMER http://biocyc.org/getid?id=MetaCyc:IPPISOM-MONOMER COG COG1304 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1304 COG COG1443 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1443 DOI 10.1002/(SICI)1097-0290(19990120)62:2<235::AID-BIT14>3.0.CO http://dx.doi.org/10.1002/(SICI)1097-0290(19990120)62:2<235::AID-BIT14>3.0.CO DOI 10.1002/prot.10573 http://dx.doi.org/10.1002/prot.10573 DOI 10.1021/ja029171p http://dx.doi.org/10.1021/ja029171p DOI 10.1021/ja040207i http://dx.doi.org/10.1021/ja040207i DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.181466998 http://dx.doi.org/10.1073/pnas.181466998 DOI 10.1074/jbc.M212823200 http://dx.doi.org/10.1074/jbc.M212823200 DOI 10.1074/jbc.M601851200 http://dx.doi.org/10.1074/jbc.M601851200 DOI 10.1093/emboj/20.7.1530 http://dx.doi.org/10.1093/emboj/20.7.1530 DOI 10.1093/oxfordjournals.jbchem.a022047 http://dx.doi.org/10.1093/oxfordjournals.jbchem.a022047 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.3.3.2 http://www.genome.jp/dbget-bin/www_bget?EC:5.3.3.2 EMBL AF119715 http://www.ebi.ac.uk/ena/data/view/AF119715 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 ENZYME 5.3.3.2 http://enzyme.expasy.org/EC/5.3.3.2 EchoBASE EB2883 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2883 EcoGene EG13072 http://www.ecogene.org/geneInfo.php?eg_id=EG13072 EnsemblBacteria AAC75927 http://www.ensemblgenomes.org/id/AAC75927 EnsemblBacteria AAC75927 http://www.ensemblgenomes.org/id/AAC75927 EnsemblBacteria BAE76954 http://www.ensemblgenomes.org/id/BAE76954 EnsemblBacteria BAE76954 http://www.ensemblgenomes.org/id/BAE76954 EnsemblBacteria BAE76954 http://www.ensemblgenomes.org/id/BAE76954 EnsemblBacteria b2889 http://www.ensemblgenomes.org/id/b2889 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004452 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004452 GO_function GO:0016787 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016787 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0008299 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008299 GO_process GO:0050992 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050992 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.90.79.10 http://www.cathdb.info/version/latest/superfamily/3.90.79.10 GeneID 949020 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949020 HAMAP MF_00202 http://hamap.expasy.org/unirule/MF_00202 HOGENOM HOG000274107 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000274107&db=HOGENOM6 InParanoid Q46822 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46822 IntAct Q46822 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46822* IntEnz 5.3.3.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.3.3.2 InterPro IPR000086 http://www.ebi.ac.uk/interpro/entry/IPR000086 InterPro IPR011876 http://www.ebi.ac.uk/interpro/entry/IPR011876 InterPro IPR015797 http://www.ebi.ac.uk/interpro/entry/IPR015797 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2857 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2857 KEGG_Gene eco:b2889 http://www.genome.jp/dbget-bin/www_bget?eco:b2889 KEGG_Orthology KO:K01823 http://www.genome.jp/dbget-bin/www_bget?KO:K01823 KEGG_Pathway ko00900 http://www.genome.jp/kegg-bin/show_pathway?ko00900 KEGG_Reaction rn:R01123 http://www.genome.jp/dbget-bin/www_bget?rn:R01123 OMA SPWMVLQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SPWMVLQ PANTHER PTHR10885 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10885 PDB 1HX3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1HX3 PDB 1HZT http://www.ebi.ac.uk/pdbe-srv/view/entry/1HZT PDB 1I9A http://www.ebi.ac.uk/pdbe-srv/view/entry/1I9A PDB 1NFS http://www.ebi.ac.uk/pdbe-srv/view/entry/1NFS PDB 1NFZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1NFZ PDB 1OW2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1OW2 PDB 1PPV http://www.ebi.ac.uk/pdbe-srv/view/entry/1PPV PDB 1PPW http://www.ebi.ac.uk/pdbe-srv/view/entry/1PPW PDB 1PVF http://www.ebi.ac.uk/pdbe-srv/view/entry/1PVF PDB 1Q54 http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q54 PDB 1R67 http://www.ebi.ac.uk/pdbe-srv/view/entry/1R67 PDB 1X83 http://www.ebi.ac.uk/pdbe-srv/view/entry/1X83 PDB 1X84 http://www.ebi.ac.uk/pdbe-srv/view/entry/1X84 PDB 2B2K http://www.ebi.ac.uk/pdbe-srv/view/entry/2B2K PDB 2G73 http://www.ebi.ac.uk/pdbe-srv/view/entry/2G73 PDB 2G74 http://www.ebi.ac.uk/pdbe-srv/view/entry/2G74 PDB 2VNP http://www.ebi.ac.uk/pdbe-srv/view/entry/2VNP PDB 2VNQ http://www.ebi.ac.uk/pdbe-srv/view/entry/2VNQ PDBsum 1HX3 http://www.ebi.ac.uk/pdbsum/1HX3 PDBsum 1HZT http://www.ebi.ac.uk/pdbsum/1HZT PDBsum 1I9A http://www.ebi.ac.uk/pdbsum/1I9A PDBsum 1NFS http://www.ebi.ac.uk/pdbsum/1NFS PDBsum 1NFZ http://www.ebi.ac.uk/pdbsum/1NFZ PDBsum 1OW2 http://www.ebi.ac.uk/pdbsum/1OW2 PDBsum 1PPV http://www.ebi.ac.uk/pdbsum/1PPV PDBsum 1PPW http://www.ebi.ac.uk/pdbsum/1PPW PDBsum 1PVF http://www.ebi.ac.uk/pdbsum/1PVF PDBsum 1Q54 http://www.ebi.ac.uk/pdbsum/1Q54 PDBsum 1R67 http://www.ebi.ac.uk/pdbsum/1R67 PDBsum 1X83 http://www.ebi.ac.uk/pdbsum/1X83 PDBsum 1X84 http://www.ebi.ac.uk/pdbsum/1X84 PDBsum 2B2K http://www.ebi.ac.uk/pdbsum/2B2K PDBsum 2G73 http://www.ebi.ac.uk/pdbsum/2G73 PDBsum 2G74 http://www.ebi.ac.uk/pdbsum/2G74 PDBsum 2VNP http://www.ebi.ac.uk/pdbsum/2VNP PDBsum 2VNQ http://www.ebi.ac.uk/pdbsum/2VNQ PROSITE PS51462 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51462 PSORT swissprot:IDI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:IDI_ECOLI PSORT-B swissprot:IDI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:IDI_ECOLI PSORT2 swissprot:IDI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:IDI_ECOLI Pfam PF00293 http://pfam.xfam.org/family/PF00293 Phobius swissprot:IDI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:IDI_ECOLI PhylomeDB Q46822 http://phylomedb.org/?seqid=Q46822 ProteinModelPortal Q46822 http://www.proteinmodelportal.org/query/uniprot/Q46822 PubMed 10099534 http://www.ncbi.nlm.nih.gov/pubmed/10099534 PubMed 10419945 http://www.ncbi.nlm.nih.gov/pubmed/10419945 PubMed 11285217 http://www.ncbi.nlm.nih.gov/pubmed/11285217 PubMed 11698677 http://www.ncbi.nlm.nih.gov/pubmed/11698677 PubMed 12540835 http://www.ncbi.nlm.nih.gov/pubmed/12540835 PubMed 12630859 http://www.ncbi.nlm.nih.gov/pubmed/12630859 PubMed 14696183 http://www.ncbi.nlm.nih.gov/pubmed/14696183 PubMed 15643873 http://www.ncbi.nlm.nih.gov/pubmed/15643873 PubMed 16617181 http://www.ncbi.nlm.nih.gov/pubmed/16617181 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9603997 http://www.ncbi.nlm.nih.gov/pubmed/9603997 RefSeq NP_417365 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417365 RefSeq WP_001192820 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001192820 SMR Q46822 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46822 STRING 511145.b2889 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2889&targetmode=cogs STRING COG1304 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1304&targetmode=cogs STRING COG1443 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1443&targetmode=cogs SUPFAM SSF55811 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55811 TIGRFAMs TIGR02150 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02150 UniProtKB IDI_ECOLI http://www.uniprot.org/uniprot/IDI_ECOLI UniProtKB-AC Q46822 http://www.uniprot.org/uniprot/Q46822 charge swissprot:IDI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:IDI_ECOLI eggNOG COG1443 http://eggnogapi.embl.de/nog_data/html/tree/COG1443 eggNOG ENOG4108ZEY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZEY epestfind swissprot:IDI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:IDI_ECOLI garnier swissprot:IDI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:IDI_ECOLI helixturnhelix swissprot:IDI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:IDI_ECOLI hmoment swissprot:IDI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:IDI_ECOLI iep swissprot:IDI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:IDI_ECOLI inforesidue swissprot:IDI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:IDI_ECOLI octanol swissprot:IDI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:IDI_ECOLI pepcoil swissprot:IDI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:IDI_ECOLI pepdigest swissprot:IDI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:IDI_ECOLI pepinfo swissprot:IDI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:IDI_ECOLI pepnet swissprot:IDI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:IDI_ECOLI pepstats swissprot:IDI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:IDI_ECOLI pepwheel swissprot:IDI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:IDI_ECOLI pepwindow swissprot:IDI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:IDI_ECOLI sigcleave swissprot:IDI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:IDI_ECOLI ## Database ID URL or Descriptions # BioGrid 4261376 16 # EcoGene EG11300 ydfA # InterPro IPR009821 DUF1391 # Organism YDFA_ECOLI Escherichia coli (strain K12) # PATRIC 32118442 VBIEscCol129921_1641 # PIR B30383 B30383 # Pfam PF07151 DUF1391 # ProDom PD019047 DUF1391 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDFA_ECOLI Uncharacterized protein YdfA # RefSeq NP_416089 NC_000913.3 # RefSeq WP_000379575 NZ_LN832404.1 # SIMILARITY To E.coli YdaF. {ECO 0000305}. BLAST swissprot:YDFA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDFA_ECOLI BioCyc ECOL316407:JW1563-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1563-MONOMER BioCyc EcoCyc:EG11300-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11300-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/16.14.6327 http://dx.doi.org/10.1093/nar/16.14.6327 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X07465 http://www.ebi.ac.uk/ena/data/view/X07465 EchoBASE EB1277 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1277 EcoGene EG11300 http://www.ecogene.org/geneInfo.php?eg_id=EG11300 EnsemblBacteria AAC74644 http://www.ensemblgenomes.org/id/AAC74644 EnsemblBacteria AAC74644 http://www.ensemblgenomes.org/id/AAC74644 EnsemblBacteria BAA15276 http://www.ensemblgenomes.org/id/BAA15276 EnsemblBacteria BAA15276 http://www.ensemblgenomes.org/id/BAA15276 EnsemblBacteria BAA15276 http://www.ensemblgenomes.org/id/BAA15276 EnsemblBacteria b1571 http://www.ensemblgenomes.org/id/b1571 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946082 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946082 HOGENOM HOG000009419 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009419&db=HOGENOM6 InterPro IPR009821 http://www.ebi.ac.uk/interpro/entry/IPR009821 KEGG_Gene ecj:JW1563 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1563 KEGG_Gene eco:b1571 http://www.genome.jp/dbget-bin/www_bget?eco:b1571 OMA NESPVYG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NESPVYG PSORT swissprot:YDFA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDFA_ECOLI PSORT-B swissprot:YDFA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDFA_ECOLI PSORT2 swissprot:YDFA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDFA_ECOLI Pfam PF07151 http://pfam.xfam.org/family/PF07151 Phobius swissprot:YDFA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDFA_ECOLI ProteinModelPortal P0ACW8 http://www.proteinmodelportal.org/query/uniprot/P0ACW8 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3041373 http://www.ncbi.nlm.nih.gov/pubmed/3041373 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416089 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416089 RefSeq WP_000379575 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000379575 STRING 511145.b1571 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1571&targetmode=cogs UniProtKB YDFA_ECOLI http://www.uniprot.org/uniprot/YDFA_ECOLI UniProtKB-AC P0ACW8 http://www.uniprot.org/uniprot/P0ACW8 charge swissprot:YDFA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDFA_ECOLI epestfind swissprot:YDFA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDFA_ECOLI garnier swissprot:YDFA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDFA_ECOLI helixturnhelix swissprot:YDFA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDFA_ECOLI hmoment swissprot:YDFA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDFA_ECOLI iep swissprot:YDFA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDFA_ECOLI inforesidue swissprot:YDFA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDFA_ECOLI octanol swissprot:YDFA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDFA_ECOLI pepcoil swissprot:YDFA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDFA_ECOLI pepdigest swissprot:YDFA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDFA_ECOLI pepinfo swissprot:YDFA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDFA_ECOLI pepnet swissprot:YDFA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDFA_ECOLI pepstats swissprot:YDFA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDFA_ECOLI pepwheel swissprot:YDFA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDFA_ECOLI pepwindow swissprot:YDFA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDFA_ECOLI sigcleave swissprot:YDFA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDFA_ECOLI ## Database ID URL or Descriptions # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # CAUTION This is a truncated ORF. Compared to E.coli W3110, the strain MG1655 has an apparent deletion of about 6 kb which seems to truncate this putative ArsB homolog. {ECO 0000305}. # CDD cd01118 ArsB_permease # EcoGene EG13208 yfjV # FUNCTION YFJV_ECOLI Involved in arsenical resistance. Thought to form the channel of an arsenite pump (By similarity). {ECO 0000250}. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0005215 transporter activity; IBA:GO_Central. # GO_function GO:0015105 arsenite transmembrane transporter activity; IEA:InterPro. # GO_process GO:0015700 arsenite transport; IEA:InterPro. # GO_process GO:0046685 response to arsenic-containing substance; IEA:UniProtKB-KW. # GO_process GO:0098656 anion transmembrane transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # GOslim_process GO:0055085 transmembrane transport # InterPro IPR000802 Arsenical_pump_ArsB # Organism YFJV_ECOLI Escherichia coli (strain K12) # PIR T08650 T08650 # PIR T08651 T08651 # PIR T08652 T08652 # PRINTS PR00758 ARSENICPUMP # Pfam PF02040 ArsB # Proteomes UP000000625 Chromosome # RecName YFJV_ECOLI Putative arsenical pump membrane protein # SEQUENCE CAUTION Sequence=AAA79807.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ArsB family. {ECO 0000305}. # SUBCELLULAR LOCATION YFJV_ECOLI Cell inner membrane {ECO 0000305}; Multi- pass membrane protein {ECO 0000305}. # TIGRFAMs TIGR00935 2a45 # eggNOG COG1055 LUCA BLAST swissprot:YFJV_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFJV_ECOLI BioCyc EcoCyc:G7375-MONOMER http://biocyc.org/getid?id=EcoCyc:G7375-MONOMER DIP DIP-12087N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12087N DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36840 http://www.ebi.ac.uk/ena/data/view/U36840 EMBL U36840 http://www.ebi.ac.uk/ena/data/view/U36840 EMBL U36840 http://www.ebi.ac.uk/ena/data/view/U36840 EchoBASE EB3000 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3000 EcoGene EG13208 http://www.ecogene.org/geneInfo.php?eg_id=EG13208 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_function GO:0015105 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015105 GO_process GO:0015700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015700 GO_process GO:0046685 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046685 GO_process GO:0098656 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098656 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 HOGENOM HOG000005271 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000005271&db=HOGENOM6 InParanoid P52137 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P52137 IntAct P52137 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P52137* InterPro IPR000802 http://www.ebi.ac.uk/interpro/entry/IPR000802 OMA FVEYATH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FVEYATH PRINTS PR00758 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00758 PSORT swissprot:YFJV_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFJV_ECOLI PSORT-B swissprot:YFJV_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFJV_ECOLI PSORT2 swissprot:YFJV_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFJV_ECOLI Pfam PF02040 http://pfam.xfam.org/family/PF02040 Phobius swissprot:YFJV_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFJV_ECOLI PhylomeDB P52137 http://phylomedb.org/?seqid=P52137 ProteinModelPortal P52137 http://www.proteinmodelportal.org/query/uniprot/P52137 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 STRING 316407.85675502 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85675502&targetmode=cogs TIGRFAMs TIGR00935 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00935 UniProtKB YFJV_ECOLI http://www.uniprot.org/uniprot/YFJV_ECOLI UniProtKB-AC P52137 http://www.uniprot.org/uniprot/P52137 charge swissprot:YFJV_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFJV_ECOLI eggNOG COG1055 http://eggnogapi.embl.de/nog_data/html/tree/COG1055 epestfind swissprot:YFJV_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFJV_ECOLI garnier swissprot:YFJV_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFJV_ECOLI helixturnhelix swissprot:YFJV_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFJV_ECOLI hmoment swissprot:YFJV_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFJV_ECOLI iep swissprot:YFJV_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFJV_ECOLI inforesidue swissprot:YFJV_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFJV_ECOLI octanol swissprot:YFJV_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFJV_ECOLI pepcoil swissprot:YFJV_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFJV_ECOLI pepdigest swissprot:YFJV_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFJV_ECOLI pepinfo swissprot:YFJV_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFJV_ECOLI pepnet swissprot:YFJV_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFJV_ECOLI pepstats swissprot:YFJV_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFJV_ECOLI pepwheel swissprot:YFJV_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFJV_ECOLI pepwindow swissprot:YFJV_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFJV_ECOLI sigcleave swissprot:YFJV_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFJV_ECOLI ## Database ID URL or Descriptions # BioGrid 4262993 129 # EcoGene EG14235 cusB # FUNCTION CUSB_ECOLI Part of a cation efflux system that mediates resistance to copper and silver. {ECO 0000269|PubMed 11399769, ECO 0000269|PubMed 12813074}. # GO_component GO:0016020 membrane; IEA:InterPro. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0005375 copper ion transmembrane transporter activity; IGI:EcoCyc. # GO_function GO:0005507 copper ion binding; IDA:EcoCyc. # GO_function GO:0046914 transition metal ion binding; IDA:EcoCyc. # GO_process GO:0006878 cellular copper ion homeostasis; IMP:EcoCyc. # GO_process GO:0010272 response to silver ion; IMP:EcoCyc. # GO_process GO:0010273 detoxification of copper ion; IMP:EcoCyc. # GO_process GO:0015679 plasma membrane copper ion transport; IGI:EcoCyc. # GO_process GO:0046688 response to copper ion; IMP:EcoliWiki. # GO_process GO:0060003 copper ion export; IGI:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0042592 homeostatic process # GOslim_process GO:0055085 transmembrane transport # INDUCTION Transcriptionally regulated by CusR in response to copper and silver ions. {ECO:0000269|PubMed 11283292}. # IntAct P77239 3 # InterPro IPR006143 RND_pump_MFP # InterPro IPR032317 HlyD_D23 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko02020 Two-component system # MISCELLANEOUS CUSB_ECOLI The cus system plays an important role in copper tolerance under anaerobic growth and, under extreme copper stress, in aerobic growth. # Organism CUSB_ECOLI Escherichia coli (strain K12) # PATRIC 32116316 VBIEscCol129921_0598 # PDB 3H94 X-ray; 3.84 A; A/B=1-407 # PDB 3NE5 X-ray; 2.90 A; B/C=1-407 # PDB 3OOC X-ray; 3.40 A; A/B=1-407 # PDB 3OPO X-ray; 3.85 A; A/B=1-407 # PDB 3OW7 X-ray; 3.78 A; A/B=1-407 # PDB 3T51 X-ray; 3.90 A; B/C=78-407 # PDB 3T53 X-ray; 3.37 A; B/C=78-407 # PDB 3T56 X-ray; 3.42 A; B/C=78-407 # PDB 4DNR X-ray; 3.68 A; B/C=1-407 # PDB 4DNT X-ray; 3.10 A; B/C=1-407 # PDB 4DOP X-ray; 4.20 A; B/C=1-407 # PIR D64790 D64790 # Pfam PF00529 HlyD # Pfam PF16576 HlyD_D23 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CUSB_ECOLI Cation efflux system protein CusB # RefSeq NP_415106 NC_000913.3 # RefSeq WP_000717157 NZ_LN832404.1 # SIMILARITY Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. {ECO 0000305}. # SUBUNIT CUSB_ECOLI The cus efflux system is composed of CusA, CusB, CusC and CusF. # TCDB 2.A.6.1 the resistance-nodulation-cell division (rnd) superfamily # TIGRFAMs TIGR01730 RND_mfp # eggNOG ENOG4105EP1 Bacteria # eggNOG ENOG410XPHF LUCA BLAST swissprot:CUSB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CUSB_ECOLI BioCyc ECOL316407:JW0563-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0563-MONOMER BioCyc EcoCyc:G6322-MONOMER http://biocyc.org/getid?id=EcoCyc:G6322-MONOMER BioCyc MetaCyc:G6322-MONOMER http://biocyc.org/getid?id=MetaCyc:G6322-MONOMER COG COG0845 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0845 DIP DIP-9346N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9346N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M104122200 http://dx.doi.org/10.1074/jbc.M104122200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.20.5864-5871.2000 http://dx.doi.org/10.1128/JB.182.20.5864-5871.2000 DOI 10.1128/JB.185.13.3804-3812.2003 http://dx.doi.org/10.1128/JB.185.13.3804-3812.2003 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB3986 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3986 EcoGene EG14235 http://www.ecogene.org/geneInfo.php?eg_id=EG14235 EnsemblBacteria AAC73675 http://www.ensemblgenomes.org/id/AAC73675 EnsemblBacteria AAC73675 http://www.ensemblgenomes.org/id/AAC73675 EnsemblBacteria BAA35208 http://www.ensemblgenomes.org/id/BAA35208 EnsemblBacteria BAA35208 http://www.ensemblgenomes.org/id/BAA35208 EnsemblBacteria BAA35208 http://www.ensemblgenomes.org/id/BAA35208 EnsemblBacteria b0574 http://www.ensemblgenomes.org/id/b0574 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0005375 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005375 GO_function GO:0005507 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005507 GO_function GO:0046914 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046914 GO_process GO:0006878 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006878 GO_process GO:0010272 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010272 GO_process GO:0010273 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010273 GO_process GO:0015679 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015679 GO_process GO:0046688 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046688 GO_process GO:0060003 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060003 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 945189 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945189 HOGENOM HOG000126091 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126091&db=HOGENOM6 InParanoid P77239 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77239 IntAct P77239 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77239* InterPro IPR006143 http://www.ebi.ac.uk/interpro/entry/IPR006143 InterPro IPR032317 http://www.ebi.ac.uk/interpro/entry/IPR032317 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW0563 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0563 KEGG_Gene eco:b0574 http://www.genome.jp/dbget-bin/www_bget?eco:b0574 KEGG_Orthology KO:K07798 http://www.genome.jp/dbget-bin/www_bget?KO:K07798 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA TISARQQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TISARQQ PDB 3H94 http://www.ebi.ac.uk/pdbe-srv/view/entry/3H94 PDB 3NE5 http://www.ebi.ac.uk/pdbe-srv/view/entry/3NE5 PDB 3OOC http://www.ebi.ac.uk/pdbe-srv/view/entry/3OOC PDB 3OPO http://www.ebi.ac.uk/pdbe-srv/view/entry/3OPO PDB 3OW7 http://www.ebi.ac.uk/pdbe-srv/view/entry/3OW7 PDB 3T51 http://www.ebi.ac.uk/pdbe-srv/view/entry/3T51 PDB 3T53 http://www.ebi.ac.uk/pdbe-srv/view/entry/3T53 PDB 3T56 http://www.ebi.ac.uk/pdbe-srv/view/entry/3T56 PDB 4DNR http://www.ebi.ac.uk/pdbe-srv/view/entry/4DNR PDB 4DNT http://www.ebi.ac.uk/pdbe-srv/view/entry/4DNT PDB 4DOP http://www.ebi.ac.uk/pdbe-srv/view/entry/4DOP PDBsum 3H94 http://www.ebi.ac.uk/pdbsum/3H94 PDBsum 3NE5 http://www.ebi.ac.uk/pdbsum/3NE5 PDBsum 3OOC http://www.ebi.ac.uk/pdbsum/3OOC PDBsum 3OPO http://www.ebi.ac.uk/pdbsum/3OPO PDBsum 3OW7 http://www.ebi.ac.uk/pdbsum/3OW7 PDBsum 3T51 http://www.ebi.ac.uk/pdbsum/3T51 PDBsum 3T53 http://www.ebi.ac.uk/pdbsum/3T53 PDBsum 3T56 http://www.ebi.ac.uk/pdbsum/3T56 PDBsum 4DNR http://www.ebi.ac.uk/pdbsum/4DNR PDBsum 4DNT http://www.ebi.ac.uk/pdbsum/4DNT PDBsum 4DOP http://www.ebi.ac.uk/pdbsum/4DOP PSORT swissprot:CUSB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CUSB_ECOLI PSORT-B swissprot:CUSB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CUSB_ECOLI PSORT2 swissprot:CUSB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CUSB_ECOLI Pfam PF00529 http://pfam.xfam.org/family/PF00529 Pfam PF16576 http://pfam.xfam.org/family/PF16576 Phobius swissprot:CUSB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CUSB_ECOLI PhylomeDB P77239 http://phylomedb.org/?seqid=P77239 ProteinModelPortal P77239 http://www.proteinmodelportal.org/query/uniprot/P77239 PubMed 11004187 http://www.ncbi.nlm.nih.gov/pubmed/11004187 PubMed 11283292 http://www.ncbi.nlm.nih.gov/pubmed/11283292 PubMed 11399769 http://www.ncbi.nlm.nih.gov/pubmed/11399769 PubMed 12813074 http://www.ncbi.nlm.nih.gov/pubmed/12813074 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415106 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415106 RefSeq WP_000717157 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000717157 SMR P77239 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77239 STRING 511145.b0574 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0574&targetmode=cogs STRING COG0845 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0845&targetmode=cogs TCDB 2.A.6.1 http://www.tcdb.org/search/result.php?tc=2.A.6.1 TIGRFAMs TIGR01730 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01730 UniProtKB CUSB_ECOLI http://www.uniprot.org/uniprot/CUSB_ECOLI UniProtKB-AC P77239 http://www.uniprot.org/uniprot/P77239 charge swissprot:CUSB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CUSB_ECOLI eggNOG ENOG4105EP1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EP1 eggNOG ENOG410XPHF http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPHF epestfind swissprot:CUSB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CUSB_ECOLI garnier swissprot:CUSB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CUSB_ECOLI helixturnhelix swissprot:CUSB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CUSB_ECOLI hmoment swissprot:CUSB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CUSB_ECOLI iep swissprot:CUSB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CUSB_ECOLI inforesidue swissprot:CUSB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CUSB_ECOLI octanol swissprot:CUSB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CUSB_ECOLI pepcoil swissprot:CUSB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CUSB_ECOLI pepdigest swissprot:CUSB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CUSB_ECOLI pepinfo swissprot:CUSB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CUSB_ECOLI pepnet swissprot:CUSB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CUSB_ECOLI pepstats swissprot:CUSB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CUSB_ECOLI pepwheel swissprot:CUSB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CUSB_ECOLI pepwindow swissprot:CUSB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CUSB_ECOLI sigcleave swissprot:CUSB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CUSB_ECOLI ## Database ID URL or Descriptions # AltName SYP_ECOLI Global RNA synthesis factor # AltName SYP_ECOLI Prolyl-tRNA synthetase # BIOPHYSICOCHEMICAL PROPERTIES SYP_ECOLI Kinetic parameters KM=0.25 mM for proline {ECO 0000269|PubMed 10922054, ECO 0000269|PubMed 11408489, ECO 0000269|PubMed 12130657}; KM=140 mM for alanine {ECO 0000269|PubMed 10922054, ECO 0000269|PubMed 11408489, ECO 0000269|PubMed 12130657}; KM=0.17 mM for cysteine {ECO 0000269|PubMed 10922054, ECO 0000269|PubMed 11408489, ECO 0000269|PubMed 12130657}; # BRENDA 6.1.1.15 2026 # BioGrid 4261629 6 # CATALYTIC ACTIVITY SYP_ECOLI ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro). # CDD cd00779 ProRS_core_prok # DOMAIN SYP_ECOLI Consists of three domains the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain. # EcoGene EG10770 proS # FUNCTION SYP_ECOLI Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). Misacylated Cys-tRNA(Pro) is not edited by ProRS, but instead may be edited in trans by YbaK. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0003723 RNA binding; IBA:GO_Central. # GO_function GO:0004827 proline-tRNA ligase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0043906 Ala-tRNA(Pro) hydrolase activity; IDA:UniProtKB. # GO_process GO:0006433 prolyl-tRNA aminoacylation; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0006520 cellular amino acid metabolic process # Gene3D 3.40.50.800 -; 1. # Gene3D 3.90.960.10 -; 1. # HAMAP MF_01569 Pro_tRNA_synth_type1 # IntAct P16659 20 # InterPro IPR002314 aa-tRNA-synt_IIb # InterPro IPR002316 Pro-tRNA-ligase_IIa # InterPro IPR004154 Anticodon-bd # InterPro IPR004500 Pro-tRNA-synth_IIa_bac-type # InterPro IPR006195 aa-tRNA-synth_II # InterPro IPR007214 YbaK/aa-tRNA-synth-assoc-dom # InterPro IPR023717 Pro-tRNA-Synthase_IIa_type1 # InterPro IPR033730 ProRS_core_prok # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01007 Amino acid related enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # KEGG_Pathway ko00970 Aminoacyl-tRNA biosynthesis # Organism SYP_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11451:SF3 PTHR11451:SF3; 2 # PATRIC 32115501 VBIEscCol129921_0202 # PIR B64744 YPEC # PIRSF PIRSF001535 ProRS_1 # PRINTS PR01046 TRNASYNTHPRO # PROSITE PS50862 AA_TRNA_LIGASE_II # Pfam PF00587 tRNA-synt_2b # Pfam PF03129 HGTP_anticodon # Pfam PF04073 tRNA_edit # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SYP_ECOLI Proline--tRNA ligase # RefSeq NP_414736 NC_000913.3 # RefSeq WP_001260717 NZ_LN832404.1 # SIMILARITY Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION SYP_ECOLI Cytoplasm. # SUBUNIT SYP_ECOLI Homodimer. # SUPFAM SSF52954 SSF52954 # SUPFAM SSF55826 SSF55826 # TIGRFAMs TIGR00409 proS_fam_II # eggNOG COG0442 LUCA # eggNOG ENOG4105C90 Bacteria BLAST swissprot:SYP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SYP_ECOLI BioCyc ECOL316407:JW0190-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0190-MONOMER BioCyc EcoCyc:PROS-MONOMER http://biocyc.org/getid?id=EcoCyc:PROS-MONOMER BioCyc MetaCyc:PROS-MONOMER http://biocyc.org/getid?id=MetaCyc:PROS-MONOMER COG COG0442 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0442 DIP DIP-10573N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10573N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1021/bi012178j http://dx.doi.org/10.1021/bi012178j DOI 10.1038/347203a0 http://dx.doi.org/10.1038/347203a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.97.16.8916 http://dx.doi.org/10.1073/pnas.97.16.8916 DOI 10.1074/jbc.M104761200 http://dx.doi.org/10.1074/jbc.M104761200 DOI 10.1074/jbc.M206928200 http://dx.doi.org/10.1074/jbc.M206928200 DOI 10.1074/jbc.M309627200 http://dx.doi.org/10.1074/jbc.M309627200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.1.1.15 http://www.genome.jp/dbget-bin/www_bget?EC:6.1.1.15 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D15061 http://www.ebi.ac.uk/ena/data/view/D15061 EMBL M32357 http://www.ebi.ac.uk/ena/data/view/M32357 EMBL M97858 http://www.ebi.ac.uk/ena/data/view/M97858 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EMBL X55518 http://www.ebi.ac.uk/ena/data/view/X55518 ENZYME 6.1.1.15 http://enzyme.expasy.org/EC/6.1.1.15 EchoBASE EB0763 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0763 EcoGene EG10770 http://www.ecogene.org/geneInfo.php?eg_id=EG10770 EnsemblBacteria AAC73305 http://www.ensemblgenomes.org/id/AAC73305 EnsemblBacteria AAC73305 http://www.ensemblgenomes.org/id/AAC73305 EnsemblBacteria BAA77870 http://www.ensemblgenomes.org/id/BAA77870 EnsemblBacteria BAA77870 http://www.ensemblgenomes.org/id/BAA77870 EnsemblBacteria BAA77870 http://www.ensemblgenomes.org/id/BAA77870 EnsemblBacteria b0194 http://www.ensemblgenomes.org/id/b0194 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0004827 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004827 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0043906 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043906 GO_process GO:0006433 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006433 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 Gene3D 3.40.50.800 http://www.cathdb.info/version/latest/superfamily/3.40.50.800 Gene3D 3.90.960.10 http://www.cathdb.info/version/latest/superfamily/3.90.960.10 GeneID 949116 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949116 HAMAP MF_01569 http://hamap.expasy.org/unirule/MF_01569 HOGENOM HOG000076893 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000076893&db=HOGENOM6 InParanoid P16659 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P16659 IntAct P16659 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P16659* IntEnz 6.1.1.15 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.1.1.15 InterPro IPR002314 http://www.ebi.ac.uk/interpro/entry/IPR002314 InterPro IPR002316 http://www.ebi.ac.uk/interpro/entry/IPR002316 InterPro IPR004154 http://www.ebi.ac.uk/interpro/entry/IPR004154 InterPro IPR004500 http://www.ebi.ac.uk/interpro/entry/IPR004500 InterPro IPR006195 http://www.ebi.ac.uk/interpro/entry/IPR006195 InterPro IPR007214 http://www.ebi.ac.uk/interpro/entry/IPR007214 InterPro IPR023717 http://www.ebi.ac.uk/interpro/entry/IPR023717 InterPro IPR033730 http://www.ebi.ac.uk/interpro/entry/IPR033730 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW0190 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0190 KEGG_Gene eco:b0194 http://www.genome.jp/dbget-bin/www_bget?eco:b0194 KEGG_Orthology KO:K01881 http://www.genome.jp/dbget-bin/www_bget?KO:K01881 KEGG_Pathway ko00970 http://www.genome.jp/kegg-bin/show_pathway?ko00970 KEGG_Reaction rn:R03661 http://www.genome.jp/dbget-bin/www_bget?rn:R03661 MINT MINT-1261583 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1261583 OMA IQPAELW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IQPAELW PANTHER PTHR11451:SF3 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11451:SF3 PRINTS PR01046 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01046 PROSITE PS50862 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50862 PSORT swissprot:SYP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SYP_ECOLI PSORT-B swissprot:SYP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SYP_ECOLI PSORT2 swissprot:SYP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SYP_ECOLI Pfam PF00587 http://pfam.xfam.org/family/PF00587 Pfam PF03129 http://pfam.xfam.org/family/PF03129 Pfam PF04073 http://pfam.xfam.org/family/PF04073 Phobius swissprot:SYP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SYP_ECOLI PhylomeDB P16659 http://phylomedb.org/?seqid=P16659 ProteinModelPortal P16659 http://www.proteinmodelportal.org/query/uniprot/P16659 PubMed 10922054 http://www.ncbi.nlm.nih.gov/pubmed/10922054 PubMed 11408489 http://www.ncbi.nlm.nih.gov/pubmed/11408489 PubMed 12033945 http://www.ncbi.nlm.nih.gov/pubmed/12033945 PubMed 12130657 http://www.ncbi.nlm.nih.gov/pubmed/12130657 PubMed 14530268 http://www.ncbi.nlm.nih.gov/pubmed/14530268 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1688424 http://www.ncbi.nlm.nih.gov/pubmed/1688424 PubMed 2203971 http://www.ncbi.nlm.nih.gov/pubmed/2203971 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_414736 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414736 RefSeq WP_001260717 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001260717 SMR P16659 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P16659 STRING 511145.b0194 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0194&targetmode=cogs STRING COG0442 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0442&targetmode=cogs SUPFAM SSF52954 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52954 SUPFAM SSF55826 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55826 SWISS-2DPAGE P16659 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P16659 TIGRFAMs TIGR00409 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00409 UniProtKB SYP_ECOLI http://www.uniprot.org/uniprot/SYP_ECOLI UniProtKB-AC P16659 http://www.uniprot.org/uniprot/P16659 charge swissprot:SYP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SYP_ECOLI eggNOG COG0442 http://eggnogapi.embl.de/nog_data/html/tree/COG0442 eggNOG ENOG4105C90 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C90 epestfind swissprot:SYP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SYP_ECOLI garnier swissprot:SYP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SYP_ECOLI helixturnhelix swissprot:SYP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SYP_ECOLI hmoment swissprot:SYP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SYP_ECOLI iep swissprot:SYP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SYP_ECOLI inforesidue swissprot:SYP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SYP_ECOLI octanol swissprot:SYP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SYP_ECOLI pepcoil swissprot:SYP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SYP_ECOLI pepdigest swissprot:SYP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SYP_ECOLI pepinfo swissprot:SYP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SYP_ECOLI pepnet swissprot:SYP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SYP_ECOLI pepstats swissprot:SYP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SYP_ECOLI pepwheel swissprot:SYP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SYP_ECOLI pepwindow swissprot:SYP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SYP_ECOLI sigcleave swissprot:SYP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SYP_ECOLI ## Database ID URL or Descriptions # CAUTION There is no equivalent of this gene in strain K12 / MG1655. {ECO 0000305}. # FUNCTION INSA8_ECOLI Absolutely required for transposition of IS1. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 1.10.10.60 -; 1. # InterPro IPR003220 InsA_N_dom # InterPro IPR009057 Homeodomain-like # InterPro IPR024431 InsA_HTH_dom # Organism INSA8_ECOLI Escherichia coli (strain K12) # PATRIC 48659221 VBIEscCol107702_0018 # Pfam PF03811 Zn_Tnp_IS1 # Pfam PF12759 HTH_Tnp_IS1 # RecName INSA8_ECOLI Insertion element IS1 8 protein InsA # RefSeq WP_000179213 NZ_LN832404.1 # SIMILARITY Belongs to the IS1 elements InsA family. {ECO 0000305}. # eggNOG COG3677 LUCA BLAST swissprot:INSA8_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSA8_ECOLI DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EnsemblBacteria BAA16126 http://www.ensemblgenomes.org/id/BAA16126 EnsemblBacteria BAA16126 http://www.ensemblgenomes.org/id/BAA16126 EnsemblBacteria BAA16126 http://www.ensemblgenomes.org/id/BAA16126 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 GeneID 24901758 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24901758 InterPro IPR003220 http://www.ebi.ac.uk/interpro/entry/IPR003220 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR024431 http://www.ebi.ac.uk/interpro/entry/IPR024431 KEGG_Gene ecj:JW2286 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2286 PSORT swissprot:INSA8_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSA8_ECOLI PSORT-B swissprot:INSA8_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSA8_ECOLI PSORT2 swissprot:INSA8_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSA8_ECOLI Pfam PF03811 http://pfam.xfam.org/family/PF03811 Pfam PF12759 http://pfam.xfam.org/family/PF12759 Phobius swissprot:INSA8_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSA8_ECOLI PhylomeDB P0CF13 http://phylomedb.org/?seqid=P0CF13 ProteinModelPortal P0CF13 http://www.proteinmodelportal.org/query/uniprot/P0CF13 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 RefSeq WP_000179213 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000179213 STRING 511145.b3444 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3444&targetmode=cogs UniProtKB INSA8_ECOLI http://www.uniprot.org/uniprot/INSA8_ECOLI UniProtKB-AC P0CF13 http://www.uniprot.org/uniprot/P0CF13 charge swissprot:INSA8_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSA8_ECOLI eggNOG COG3677 http://eggnogapi.embl.de/nog_data/html/tree/COG3677 epestfind swissprot:INSA8_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSA8_ECOLI garnier swissprot:INSA8_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSA8_ECOLI helixturnhelix swissprot:INSA8_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSA8_ECOLI hmoment swissprot:INSA8_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSA8_ECOLI iep swissprot:INSA8_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSA8_ECOLI inforesidue swissprot:INSA8_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSA8_ECOLI octanol swissprot:INSA8_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSA8_ECOLI pepcoil swissprot:INSA8_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSA8_ECOLI pepdigest swissprot:INSA8_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSA8_ECOLI pepinfo swissprot:INSA8_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSA8_ECOLI pepnet swissprot:INSA8_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSA8_ECOLI pepstats swissprot:INSA8_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSA8_ECOLI pepwheel swissprot:INSA8_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSA8_ECOLI pepwindow swissprot:INSA8_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSA8_ECOLI sigcleave swissprot:INSA8_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSA8_ECOLI ## Database ID URL or Descriptions # BioGrid 4261887 545 # CDD cd02201 FtsZ_type1 # DOMAIN FTSZ_ECOLI The central and C-terminal regions are required for dimerization. {ECO 0000269|PubMed 10231484}. # ENZYME REGULATION FTSZ_ECOLI Formation of the FtsZ ring is inhibited by SulA, MinCD, DicB and toxins CbtA and CptA. Inhibition by toxin CbtA, SulA or DicB overexpression is neutralized by cytoskeleton bundling-enhancing protein CbeA, while inhibition by toxin CptA is neutralized by antitoxin CptB (PubMed 21166897, PubMed 22239607, PubMed 22515815, PubMed 8752322). Either FtsA or ZipA is required for Z ring formation and stabilization (PubMed 11847116). {ECO 0000269|PubMed 11847116, ECO 0000269|PubMed 21166897, ECO 0000269|PubMed 22239607, ECO 0000269|PubMed 22515815, ECO 0000269|PubMed 8752322}. # EcoGene EG10347 ftsZ # FUNCTION FTSZ_ECOLI Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. Polymerization and bundle formation is enhanced by CbeA. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0032153 cell division site; IDA:EcoliWiki. # GO_function GO:0003924 GTPase activity; IDA:EcoliWiki. # GO_function GO:0005525 GTP binding; IDA:EcoliWiki. # GO_function GO:0042802 identical protein binding; IPI:IntAct. # GO_process GO:0043093 FtsZ-dependent cytokinesis; IEA:UniProtKB-HAMAP. # GO_process GO:0051258 protein polymerization; IDA:EcoliWiki. # GO_process GO:0051301 cell division; IGI:CACAO. # GO_process GO:0090529 cell septum assembly; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003924 GTPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0008150 biological_process # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0051301 cell division # Gene3D 3.30.1330.20 -; 1. # Gene3D 3.40.50.1440 -; 1. # HAMAP MF_00909 FtsZ # INDUCTION Repressed 1.3-fold by hydroxyurea (at protein level). {ECO:0000269|PubMed 20005847}. # INTERACTION FTSZ_ECOLI Self; NbExp=7; IntAct=EBI-370963, EBI-370963; P76364 cbeA; NbExp=2; IntAct=EBI-370963, EBI-1126877; P0ABH0 ftsA; NbExp=6; IntAct=EBI-370963, EBI-550562; P0A9R7 ftsE; NbExp=2; IntAct=EBI-370963, EBI-550637; P0A9X4 mreB; NbExp=6; IntAct=EBI-370963, EBI-371008; P36979 rlmN; NbExp=3; IntAct=EBI-370963, EBI-559071; P75862 zapC; NbExp=5; IntAct=EBI-370963, EBI-552519; P36680 zapD; NbExp=3; IntAct=EBI-370963, EBI-1113728; P77173 zipA; NbExp=4; IntAct=EBI-370963, EBI-1029213; # IntAct P0A9A6 59 # InterPro IPR000158 Cell_div_FtsZ # InterPro IPR003008 Tubulin_FtsZ_GTPase # InterPro IPR008280 Tub_FtsZ_C # InterPro IPR018316 Tubulin/FtsZ_2-layer-sand-dom # InterPro IPR020805 Cell_div_FtsZ_CS # InterPro IPR024757 FtsZ_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko03036 Chromosome # KEGG_Brite ko04812 Cytoskeleton proteins # KEGG_Pathway ko04112 Cell cycle - Caulobacter # Organism FTSZ_ECOLI Escherichia coli (strain K12) # PATRIC 32115295 VBIEscCol129921_0099 # PDB 1F47 X-ray; 1.95 A; A=367-383 # PDB 5HAW X-ray; 1.89 A; K/L=370-379 # PDB 5HBU X-ray; 2.60 A; K=370-379 # PDB 5HSZ X-ray; 2.30 A; K=372-382 # PDB 5K58 X-ray; 2.77 A; K/L/M/N=372-379 # PIR G64731 CEECZ # PRINTS PR00423 CELLDVISFTSZ # PROSITE PS01134 FTSZ_1 # PROSITE PS01135 FTSZ_2 # Pfam PF00091 Tubulin # Pfam PF12327 FtsZ_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Cell division protein FtsZ {ECO:0000255|HAMAP-Rule MF_00909} # RefSeq NP_414637 NC_000913.3 # RefSeq WP_000462776 NZ_LN832404.1 # SIMILARITY Belongs to the FtsZ family. {ECO:0000255|HAMAP- Rule MF_00909}. # SMART SM00864 Tubulin # SMART SM00865 Tubulin_C # SUBCELLULAR LOCATION FTSZ_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00909, ECO 0000269|PubMed 1944597, ECO 0000269|PubMed 8917533}. Note=Assembles at midcell at the inner surface of the cytoplasmic membrane. # SUBUNIT FTSZ_ECOLI Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Polymers persist as long as GTP is present and disappear rapidly as soon as it is consumed. Interacts directly with several other division proteins, including FtsA and ZipA. Interacts with polymerization inhibitors SulA, CbtA and CptA. Interacts with MreB and polymerization bundling- enhancing factor CbeA. {ECO 0000269|PubMed 10231484, ECO 0000269|PubMed 10880432, ECO 0000269|PubMed 14705956, ECO 0000269|PubMed 17307852, ECO 0000269|PubMed 21166897, ECO 0000269|PubMed 22239607, ECO 0000269|PubMed 22515815, ECO 0000269|PubMed 8752322, ECO 0000269|PubMed 8917533, ECO 0000269|PubMed 9430638}. # SUPFAM SSF52490 SSF52490 # SUPFAM SSF55307 SSF55307 # TIGRFAMs TIGR00065 ftsZ # WEB RESOURCE FTSZ_ECOLI Name=Protein Spotlight; Note=Becoming two - Issue 171 of July 2015; URL="http //web.expasy.org/spotlight/back_issues/171/"; # eggNOG COG0206 LUCA # eggNOG ENOG4105CDK Bacteria BLAST swissprot:FTSZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FTSZ_ECOLI BioCyc ECOL316407:JW0093-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0093-MONOMER BioCyc EcoCyc:EG10347-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10347-MONOMER COG COG0206 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0206 DIP DIP-31873N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31873N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1007/s00239-003-2523-5 http://dx.doi.org/10.1007/s00239-003-2523-5 DOI 10.1016/0022-2836(85)90290-6 http://dx.doi.org/10.1016/0022-2836(85)90290-6 DOI 10.1016/0378-1119(85)90179-9 http://dx.doi.org/10.1016/0378-1119(85)90179-9 DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1021/bi035465r http://dx.doi.org/10.1021/bi035465r DOI 10.1038/354161a0 http://dx.doi.org/10.1038/354161a0 DOI 10.1038/359251a0 http://dx.doi.org/10.1038/359251a0 DOI 10.1038/359254a0 http://dx.doi.org/10.1038/359254a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1999.01344.x http://dx.doi.org/10.1046/j.1365-2958.1999.01344.x DOI 10.1073/pnas.91.13.5813 http://dx.doi.org/10.1073/pnas.91.13.5813 DOI 10.1073/pnas.93.23.12998 http://dx.doi.org/10.1073/pnas.93.23.12998 DOI 10.1093/emboj/17.2.462 http://dx.doi.org/10.1093/emboj/17.2.462 DOI 10.1093/emboj/19.13.3179 http://dx.doi.org/10.1093/emboj/19.13.3179 DOI 10.1093/emboj/21.4.685 http://dx.doi.org/10.1093/emboj/21.4.685 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1111/j.1365-2958.2004.04283.x http://dx.doi.org/10.1111/j.1365-2958.2004.04283.x DOI 10.1111/j.1365-2958.2010.07433.x http://dx.doi.org/10.1111/j.1365-2958.2010.07433.x DOI 10.1111/j.1365-2958.2012.08068.x http://dx.doi.org/10.1111/j.1365-2958.2012.08068.x DOI 10.1111/j.1574-6968.2012.02496.x http://dx.doi.org/10.1111/j.1574-6968.2012.02496.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01581-06 http://dx.doi.org/10.1128/JB.01581-06 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K02668 http://www.ebi.ac.uk/ena/data/view/K02668 EMBL M19211 http://www.ebi.ac.uk/ena/data/view/M19211 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X55034 http://www.ebi.ac.uk/ena/data/view/X55034 EchoBASE EB0343 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0343 EcoGene EG10347 http://www.ecogene.org/geneInfo.php?eg_id=EG10347 EnsemblBacteria AAC73206 http://www.ensemblgenomes.org/id/AAC73206 EnsemblBacteria AAC73206 http://www.ensemblgenomes.org/id/AAC73206 EnsemblBacteria BAB96663 http://www.ensemblgenomes.org/id/BAB96663 EnsemblBacteria BAB96663 http://www.ensemblgenomes.org/id/BAB96663 EnsemblBacteria BAB96663 http://www.ensemblgenomes.org/id/BAB96663 EnsemblBacteria b0095 http://www.ensemblgenomes.org/id/b0095 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0032153 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032153 GO_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0043093 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043093 GO_process GO:0051258 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051258 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GO_process GO:0090529 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090529 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 Gene3D 3.30.1330.20 http://www.cathdb.info/version/latest/superfamily/3.30.1330.20 Gene3D 3.40.50.1440 http://www.cathdb.info/version/latest/superfamily/3.40.50.1440 GeneID 944786 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944786 HAMAP MF_00909 http://hamap.expasy.org/unirule/MF_00909 HOGENOM HOG000049094 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000049094&db=HOGENOM6 InParanoid P0A9A6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9A6 IntAct P0A9A6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9A6* InterPro IPR000158 http://www.ebi.ac.uk/interpro/entry/IPR000158 InterPro IPR003008 http://www.ebi.ac.uk/interpro/entry/IPR003008 InterPro IPR008280 http://www.ebi.ac.uk/interpro/entry/IPR008280 InterPro IPR018316 http://www.ebi.ac.uk/interpro/entry/IPR018316 InterPro IPR020805 http://www.ebi.ac.uk/interpro/entry/IPR020805 InterPro IPR024757 http://www.ebi.ac.uk/interpro/entry/IPR024757 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Brite ko04812 http://www.genome.jp/dbget-bin/www_bget?ko04812 KEGG_Gene ecj:JW0093 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0093 KEGG_Gene eco:b0095 http://www.genome.jp/dbget-bin/www_bget?eco:b0095 KEGG_Orthology KO:K03531 http://www.genome.jp/dbget-bin/www_bget?KO:K03531 KEGG_Pathway ko04112 http://www.genome.jp/kegg-bin/show_pathway?ko04112 MINT MINT-8092601 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8092601 OMA GMAMMGI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GMAMMGI PDB 1F47 http://www.ebi.ac.uk/pdbe-srv/view/entry/1F47 PDB 5HAW http://www.ebi.ac.uk/pdbe-srv/view/entry/5HAW PDB 5HBU http://www.ebi.ac.uk/pdbe-srv/view/entry/5HBU PDB 5HSZ http://www.ebi.ac.uk/pdbe-srv/view/entry/5HSZ PDB 5K58 http://www.ebi.ac.uk/pdbe-srv/view/entry/5K58 PDBsum 1F47 http://www.ebi.ac.uk/pdbsum/1F47 PDBsum 5HAW http://www.ebi.ac.uk/pdbsum/5HAW PDBsum 5HBU http://www.ebi.ac.uk/pdbsum/5HBU PDBsum 5HSZ http://www.ebi.ac.uk/pdbsum/5HSZ PDBsum 5K58 http://www.ebi.ac.uk/pdbsum/5K58 PRINTS PR00423 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00423 PROSITE PS01134 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01134 PROSITE PS01135 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01135 PSORT swissprot:FTSZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FTSZ_ECOLI PSORT-B swissprot:FTSZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FTSZ_ECOLI PSORT2 swissprot:FTSZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FTSZ_ECOLI Pfam PF00091 http://pfam.xfam.org/family/PF00091 Pfam PF12327 http://pfam.xfam.org/family/PF12327 Phobius swissprot:FTSZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FTSZ_ECOLI PhylomeDB P0A9A6 http://phylomedb.org/?seqid=P0A9A6 ProteinModelPortal P0A9A6 http://www.proteinmodelportal.org/query/uniprot/P0A9A6 PubMed 10231484 http://www.ncbi.nlm.nih.gov/pubmed/10231484 PubMed 10880432 http://www.ncbi.nlm.nih.gov/pubmed/10880432 PubMed 11847116 http://www.ncbi.nlm.nih.gov/pubmed/11847116 PubMed 14705956 http://www.ncbi.nlm.nih.gov/pubmed/14705956 PubMed 14743312 http://www.ncbi.nlm.nih.gov/pubmed/14743312 PubMed 1528267 http://www.ncbi.nlm.nih.gov/pubmed/1528267 PubMed 1528268 http://www.ncbi.nlm.nih.gov/pubmed/1528268 PubMed 15491352 http://www.ncbi.nlm.nih.gov/pubmed/15491352 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17307852 http://www.ncbi.nlm.nih.gov/pubmed/17307852 PubMed 1944597 http://www.ncbi.nlm.nih.gov/pubmed/1944597 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 21166897 http://www.ncbi.nlm.nih.gov/pubmed/21166897 PubMed 22239607 http://www.ncbi.nlm.nih.gov/pubmed/22239607 PubMed 22515815 http://www.ncbi.nlm.nih.gov/pubmed/22515815 PubMed 2824434 http://www.ncbi.nlm.nih.gov/pubmed/2824434 PubMed 2995680 http://www.ncbi.nlm.nih.gov/pubmed/2995680 PubMed 3000876 http://www.ncbi.nlm.nih.gov/pubmed/3000876 PubMed 6094474 http://www.ncbi.nlm.nih.gov/pubmed/6094474 PubMed 8016071 http://www.ncbi.nlm.nih.gov/pubmed/8016071 PubMed 8083192 http://www.ncbi.nlm.nih.gov/pubmed/8083192 PubMed 8169229 http://www.ncbi.nlm.nih.gov/pubmed/8169229 PubMed 8752322 http://www.ncbi.nlm.nih.gov/pubmed/8752322 PubMed 8917533 http://www.ncbi.nlm.nih.gov/pubmed/8917533 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9430638 http://www.ncbi.nlm.nih.gov/pubmed/9430638 RefSeq NP_414637 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414637 RefSeq WP_000462776 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000462776 SMART SM00864 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00864 SMART SM00865 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00865 SMR P0A9A6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9A6 STRING 511145.b0095 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0095&targetmode=cogs STRING COG0206 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0206&targetmode=cogs SUPFAM SSF52490 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52490 SUPFAM SSF55307 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55307 SWISS-2DPAGE P0A9A6 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A9A6 TIGRFAMs TIGR00065 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00065 UniProtKB FTSZ_ECOLI http://www.uniprot.org/uniprot/FTSZ_ECOLI UniProtKB-AC P0A9A6 http://www.uniprot.org/uniprot/P0A9A6 charge swissprot:FTSZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FTSZ_ECOLI eggNOG COG0206 http://eggnogapi.embl.de/nog_data/html/tree/COG0206 eggNOG ENOG4105CDK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CDK epestfind swissprot:FTSZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FTSZ_ECOLI garnier swissprot:FTSZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FTSZ_ECOLI helixturnhelix swissprot:FTSZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FTSZ_ECOLI hmoment swissprot:FTSZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FTSZ_ECOLI iep swissprot:FTSZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FTSZ_ECOLI inforesidue swissprot:FTSZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FTSZ_ECOLI octanol swissprot:FTSZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FTSZ_ECOLI pepcoil swissprot:FTSZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FTSZ_ECOLI pepdigest swissprot:FTSZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FTSZ_ECOLI pepinfo swissprot:FTSZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FTSZ_ECOLI pepnet swissprot:FTSZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FTSZ_ECOLI pepstats swissprot:FTSZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FTSZ_ECOLI pepwheel swissprot:FTSZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FTSZ_ECOLI pepwindow swissprot:FTSZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FTSZ_ECOLI sigcleave swissprot:FTSZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FTSZ_ECOLI ## Database ID URL or Descriptions # AltName FRDD_ECOLI Fumarate reductase 13 kDa hydrophobic protein # BioGrid 4262699 457 # CDD cd00547 QFR_TypeD_subunitD # EcoGene EG10333 frdD # FUNCTION FRDD_ECOLI Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0045284 plasma membrane fumarate reductase complex; IDA:EcoCyc. # GO_function GO:0000104 succinate dehydrogenase activity; IDA:EcoCyc. # GO_function GO:0008177 succinate dehydrogenase (ubiquinone) activity; IMP:EcoCyc. # GO_process GO:0006106 fumarate metabolic process; IEA:InterPro. # GO_process GO:0006113 fermentation; IMP:EcoCyc. # GO_process GO:0009061 anaerobic respiration; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0044281 small molecule metabolic process # HAMAP MF_00709 Fumarate_red_D # INDUCTION Regulated at the transcriptional level in response to the cellular availability of the alternate electron acceptors oxygen, nitrate, and fumarate. {ECO:0000269|PubMed 2999070}. # InterPro IPR003418 Fumarate_red_D # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Pathway ko00020 Citrate cycle (TCA cycle) # KEGG_Pathway ko00190 Oxidative phosphorylation # KEGG_Pathway ko00623 Toluene degradation # KEGG_Pathway ko00650 Butanoate metabolism # KEGG_Pathway ko00720 Carbon fixation pathways in prokaryotes # KEGG_Pathway ko02020 Two-component system # Organism FRDD_ECOLI Escherichia coli (strain K12) # PATRIC 32123875 VBIEscCol129921_4285 # PDB 1KF6 X-ray; 2.70 A; D/P=1-119 # PDB 1KFY X-ray; 3.60 A; D/P=1-119 # PDB 1L0V X-ray; 3.30 A; D/P=1-119 # PDB 2B76 X-ray; 3.30 A; D/P=1-119 # PDB 3CIR X-ray; 3.65 A; D/P=1-119 # PDB 3P4P X-ray; 2.80 A; D/P=1-119 # PDB 3P4Q X-ray; 3.35 A; D/P=1-119 # PDB 3P4R X-ray; 3.05 A; D/P=1-119 # PDB 3P4S X-ray; 3.10 A; D/P=1-119 # PDB 4KX6 X-ray; 2.95 A; D/P=1-119 # PIR A04431 WMEC13 # PIRSF PIRSF000179 FrdD # Pfam PF02313 Fumarate_red_D # ProDom PD015693 Fumarate_red_D # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FRDD_ECOLI Fumarate reductase subunit D # RefSeq NP_418575 NC_000913.3 # RefSeq WP_000609663 NZ_LN832404.1 # SIMILARITY Belongs to the FrdD family. {ECO 0000305}. # SUBCELLULAR LOCATION FRDD_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT Part of an enzyme complex containing four subunits a flavoprotein (FrdA), an iron-sulfur protein (FrdB), and two hydrophobic anchor proteins (FrdC and FrdD). # eggNOG COG3080 LUCA # eggNOG ENOG4108VP9 Bacteria BLAST swissprot:FRDD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FRDD_ECOLI BioCyc ECOL316407:JW4112-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4112-MONOMER BioCyc EcoCyc:FUM-MEMB2 http://biocyc.org/getid?id=EcoCyc:FUM-MEMB2 BioCyc MetaCyc:FUM-MEMB2 http://biocyc.org/getid?id=MetaCyc:FUM-MEMB2 COG COG3080 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3080 DIP DIP-9684N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9684N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.79.4.1111 http://dx.doi.org/10.1073/pnas.79.4.1111 DOI 10.1073/pnas.80.24.7556 http://dx.doi.org/10.1073/pnas.80.24.7556 DOI 10.1073/pnas.96.22.12412 http://dx.doi.org/10.1073/pnas.96.22.12412 DOI 10.1074/jbc.M200815200 http://dx.doi.org/10.1074/jbc.M200815200 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1126/science.284.5422.1961 http://dx.doi.org/10.1126/science.284.5422.1961 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01611 http://www.ebi.ac.uk/ena/data/view/J01611 EMBL M11979 http://www.ebi.ac.uk/ena/data/view/M11979 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL V00277 http://www.ebi.ac.uk/ena/data/view/V00277 EchoBASE EB0329 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0329 EcoGene EG10333 http://www.ecogene.org/geneInfo.php?eg_id=EG10333 EnsemblBacteria AAC77111 http://www.ensemblgenomes.org/id/AAC77111 EnsemblBacteria AAC77111 http://www.ensemblgenomes.org/id/AAC77111 EnsemblBacteria BAE78155 http://www.ensemblgenomes.org/id/BAE78155 EnsemblBacteria BAE78155 http://www.ensemblgenomes.org/id/BAE78155 EnsemblBacteria BAE78155 http://www.ensemblgenomes.org/id/BAE78155 EnsemblBacteria b4151 http://www.ensemblgenomes.org/id/b4151 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0045284 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045284 GO_function GO:0000104 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000104 GO_function GO:0008177 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008177 GO_process GO:0006106 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006106 GO_process GO:0006113 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006113 GO_process GO:0009061 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009061 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 948668 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948668 HAMAP MF_00709 http://hamap.expasy.org/unirule/MF_00709 HOGENOM HOG000281495 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000281495&db=HOGENOM6 IntAct P0A8Q3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8Q3* InterPro IPR003418 http://www.ebi.ac.uk/interpro/entry/IPR003418 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Gene ecj:JW4112 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4112 KEGG_Gene eco:b4151 http://www.genome.jp/dbget-bin/www_bget?eco:b4151 KEGG_Orthology KO:K00247 http://www.genome.jp/dbget-bin/www_bget?KO:K00247 KEGG_Pathway ko00020 http://www.genome.jp/kegg-bin/show_pathway?ko00020 KEGG_Pathway ko00190 http://www.genome.jp/kegg-bin/show_pathway?ko00190 KEGG_Pathway ko00623 http://www.genome.jp/kegg-bin/show_pathway?ko00623 KEGG_Pathway ko00650 http://www.genome.jp/kegg-bin/show_pathway?ko00650 KEGG_Pathway ko00720 http://www.genome.jp/kegg-bin/show_pathway?ko00720 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 KEGG_Reaction rn:R00408 http://www.genome.jp/dbget-bin/www_bget?rn:R00408 KEGG_Reaction rn:R00412 http://www.genome.jp/dbget-bin/www_bget?rn:R00412 OMA GMWSAIV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GMWSAIV PDB 1KF6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1KF6 PDB 1KFY http://www.ebi.ac.uk/pdbe-srv/view/entry/1KFY PDB 1L0V http://www.ebi.ac.uk/pdbe-srv/view/entry/1L0V PDB 2B76 http://www.ebi.ac.uk/pdbe-srv/view/entry/2B76 PDB 3CIR http://www.ebi.ac.uk/pdbe-srv/view/entry/3CIR PDB 3P4P http://www.ebi.ac.uk/pdbe-srv/view/entry/3P4P PDB 3P4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/3P4Q PDB 3P4R http://www.ebi.ac.uk/pdbe-srv/view/entry/3P4R PDB 3P4S http://www.ebi.ac.uk/pdbe-srv/view/entry/3P4S PDB 4KX6 http://www.ebi.ac.uk/pdbe-srv/view/entry/4KX6 PDBsum 1KF6 http://www.ebi.ac.uk/pdbsum/1KF6 PDBsum 1KFY http://www.ebi.ac.uk/pdbsum/1KFY PDBsum 1L0V http://www.ebi.ac.uk/pdbsum/1L0V PDBsum 2B76 http://www.ebi.ac.uk/pdbsum/2B76 PDBsum 3CIR http://www.ebi.ac.uk/pdbsum/3CIR PDBsum 3P4P http://www.ebi.ac.uk/pdbsum/3P4P PDBsum 3P4Q http://www.ebi.ac.uk/pdbsum/3P4Q PDBsum 3P4R http://www.ebi.ac.uk/pdbsum/3P4R PDBsum 3P4S http://www.ebi.ac.uk/pdbsum/3P4S PDBsum 4KX6 http://www.ebi.ac.uk/pdbsum/4KX6 PSORT swissprot:FRDD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FRDD_ECOLI PSORT-B swissprot:FRDD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FRDD_ECOLI PSORT2 swissprot:FRDD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FRDD_ECOLI Pfam PF02313 http://pfam.xfam.org/family/PF02313 Phobius swissprot:FRDD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FRDD_ECOLI ProteinModelPortal P0A8Q3 http://www.proteinmodelportal.org/query/uniprot/P0A8Q3 PubMed 10373108 http://www.ncbi.nlm.nih.gov/pubmed/10373108 PubMed 10535936 http://www.ncbi.nlm.nih.gov/pubmed/10535936 PubMed 11850430 http://www.ncbi.nlm.nih.gov/pubmed/11850430 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2999070 http://www.ncbi.nlm.nih.gov/pubmed/2999070 PubMed 6369321 http://www.ncbi.nlm.nih.gov/pubmed/6369321 PubMed 7041115 http://www.ncbi.nlm.nih.gov/pubmed/7041115 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418575 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418575 RefSeq WP_000609663 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000609663 SMR P0A8Q3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8Q3 STRING 511145.b4151 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4151&targetmode=cogs STRING COG3080 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3080&targetmode=cogs UniProtKB FRDD_ECOLI http://www.uniprot.org/uniprot/FRDD_ECOLI UniProtKB-AC P0A8Q3 http://www.uniprot.org/uniprot/P0A8Q3 charge swissprot:FRDD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FRDD_ECOLI eggNOG COG3080 http://eggnogapi.embl.de/nog_data/html/tree/COG3080 eggNOG ENOG4108VP9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108VP9 epestfind swissprot:FRDD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FRDD_ECOLI garnier swissprot:FRDD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FRDD_ECOLI helixturnhelix swissprot:FRDD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FRDD_ECOLI hmoment swissprot:FRDD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FRDD_ECOLI iep swissprot:FRDD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FRDD_ECOLI inforesidue swissprot:FRDD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FRDD_ECOLI octanol swissprot:FRDD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FRDD_ECOLI pepcoil swissprot:FRDD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FRDD_ECOLI pepdigest swissprot:FRDD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FRDD_ECOLI pepinfo swissprot:FRDD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FRDD_ECOLI pepnet swissprot:FRDD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FRDD_ECOLI pepstats swissprot:FRDD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FRDD_ECOLI pepwheel swissprot:FRDD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FRDD_ECOLI pepwindow swissprot:FRDD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FRDD_ECOLI sigcleave swissprot:FRDD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FRDD_ECOLI ## Database ID URL or Descriptions # AltName OMPF_ECOLI Outer membrane protein 1A # AltName OMPF_ECOLI Outer membrane protein B # AltName OMPF_ECOLI Outer membrane protein IA # AltName OMPF_ECOLI Porin OmpF # BioGrid 4260018 305 # CDD cd00342 gram_neg_porins # DISRUPTION PHENOTYPE Leads to decreased susceptibility to a number of hydrophilic antibiotics including ampicillin, cefoxitin and tetracycline. {ECO:0000269|PubMed 19721064}. # EcoGene EG10671 ompF # FUNCTION OMPF_ECOLI Forms pores that allow passive diffusion of small molecules across the outer membrane. It is also a receptor for the bacteriophage T2. {ECO 0000269|PubMed 19721064}. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_component GO:0046930 pore complex; IDA:EcoCyc. # GO_function GO:0015075 ion transmembrane transporter activity; TAS:EcoCyc. # GO_function GO:0015238 drug transmembrane transporter activity; IMP:EcoCyc. # GO_function GO:0015288 porin activity; IMP:EcoliWiki. # GO_function GO:0042912 colicin transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0006855 drug transmembrane transport; IMP:EcoCyc. # GO_process GO:0034220 ion transmembrane transport; TAS:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043234 protein complex # GOslim_function GO:0008565 protein transporter activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0055085 transmembrane transport # Gene3D 2.40.160.10 -; 1. # INDUCTION Levels of OmpF protein decrease in a lon/ycgE double disruption (at protein level). {ECO:0000269|PubMed 19721064}. # IntAct P02931 5 # InterPro IPR001702 Porin_Gram-ve # InterPro IPR001897 Porin_gammaproteobac # InterPro IPR013793 Porin_Gram-ve_CS # InterPro IPR023614 Porin_dom # InterPro IPR033900 Gram_neg_porin_domain # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02020 Two-component system # Organism OMPF_ECOLI Escherichia coli (strain K12) # PATRIC 32117073 VBIEscCol129921_0961 # PDB 1BT9 X-ray; 3.00 A; A=23-362 # PDB 1GFM X-ray; 3.50 A; A=23-362 # PDB 1GFN X-ray; 3.10 A; A=23-362 # PDB 1GFO X-ray; 3.30 A; A=23-362 # PDB 1GFP X-ray; 2.70 A; A=23-362 # PDB 1GFQ X-ray; 2.80 A; A=23-362 # PDB 1HXT X-ray; 2.40 A; A=23-362 # PDB 1HXU X-ray; 3.00 A; A=23-362 # PDB 1HXX X-ray; 2.20 A; A=23-362 # PDB 1MPF X-ray; 3.00 A; A=23-362 # PDB 1OPF X-ray; 3.20 A; A/B/C/D/E/F=23-362 # PDB 2OMF X-ray; 2.40 A; A=23-362 # PDB 2ZFG X-ray; 1.59 A; A=23-362 # PDB 2ZLD X-ray; 3.00 A; A/B=23-362 # PDB 3FYX X-ray; 3.40 A; A=23-362 # PDB 3HW9 X-ray; 2.61 A; A/B=1-362 # PDB 3HWB X-ray; 3.00 A; A/B=1-362 # PDB 3K19 X-ray; 3.79 A; A/B/C/D/E/F/G/H/I/J/K/L=23-362 # PDB 3K1B X-ray; 4.39 A; A/B/C/D=23-362 # PDB 3O0E X-ray; 3.01 A; A/B/C/D/E/F=23-362 # PDB 3POQ X-ray; 1.90 A; A=23-362 # PDB 3POU X-ray; 2.80 A; A=23-362 # PDB 3POX X-ray; 2.00 A; A/B/C/D/E/F=23-362 # PDB 4D5U X-ray; 3.50 A; A/B/C/D/E/F=23-362 # PDB 4GCP X-ray; 1.98 A; A/B=23-362 # PDB 4GCQ X-ray; 2.20 A; A/B=23-362 # PDB 4GCS X-ray; 1.87 A; A/B=23-362 # PDB 4JFB X-ray; 3.80 A; A/B/C/D/E/F=23-362 # PDB 4LSE X-ray; 2.10 A; A/B/C=23-362 # PDB 4LSF X-ray; 1.90 A; A/B=23-362 # PDB 4LSH X-ray; 2.20 A; A/B=23-362 # PDB 4LSI X-ray; 2.09 A; A/B/C=23-362 # PIR A93449 MMECF # PRINTS PR00182 ECOLNEIPORIN # PRINTS PR00183 ECOLIPORIN # PROSITE PS00576 GRAM_NEG_PORIN # Pfam PF00267 Porin_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName OMPF_ECOLI Outer membrane protein F # RefSeq NP_415449 NC_000913.3 # RefSeq WP_000977920 NZ_LN832404.1 # SIMILARITY Belongs to the Gram-negative porin family. {ECO 0000305}. # SUBCELLULAR LOCATION OMPF_ECOLI Cell outer membrane {ECO 0000269|PubMed 16079137}; Multi-pass membrane protein {ECO 0000269|PubMed 16079137}. # SUBUNIT Homotrimer. {ECO:0000269|PubMed 16079137}. # TCDB 1.B.1.1 the general bacterial porin (gbp) family # eggNOG COG3203 LUCA # eggNOG ENOG4105FCK Bacteria BLAST swissprot:OMPF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:OMPF_ECOLI BioCyc ECOL316407:JW0912-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0912-MONOMER BioCyc EcoCyc:EG10671-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10671-MONOMER BioCyc MetaCyc:EG10671-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10671-MONOMER COG COG3203 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3203 DIP DIP-10398N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10398N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1002/elps.1150190539 http://dx.doi.org/10.1002/elps.1150190539 DOI 10.1016/0014-5793(82)80341-4 http://dx.doi.org/10.1016/0014-5793(82)80341-4 DOI 10.1021/bi981215c http://dx.doi.org/10.1021/bi981215c DOI 10.1038/358727a0 http://dx.doi.org/10.1038/358727a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2030033 http://dx.doi.org/10.1042/bj2030033 DOI 10.1073/pnas.91.22.10675 http://dx.doi.org/10.1073/pnas.91.22.10675 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/10.21.6957 http://dx.doi.org/10.1093/nar/10.21.6957 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AAC.00787-09 http://dx.doi.org/10.1128/AAC.00787-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01655 http://www.ebi.ac.uk/ena/data/view/J01655 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0665 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0665 EcoGene EG10671 http://www.ecogene.org/geneInfo.php?eg_id=EG10671 EnsemblBacteria AAC74015 http://www.ensemblgenomes.org/id/AAC74015 EnsemblBacteria AAC74015 http://www.ensemblgenomes.org/id/AAC74015 EnsemblBacteria BAA35675 http://www.ensemblgenomes.org/id/BAA35675 EnsemblBacteria BAA35675 http://www.ensemblgenomes.org/id/BAA35675 EnsemblBacteria BAA35675 http://www.ensemblgenomes.org/id/BAA35675 EnsemblBacteria b0929 http://www.ensemblgenomes.org/id/b0929 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0046930 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046930 GO_function GO:0015075 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015075 GO_function GO:0015238 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015238 GO_function GO:0015288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015288 GO_function GO:0042912 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042912 GO_process GO:0006855 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006855 GO_process GO:0034220 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 2.40.160.10 http://www.cathdb.info/version/latest/superfamily/2.40.160.10 GeneID 945554 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945554 HOGENOM HOG000272406 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000272406&db=HOGENOM6 InParanoid P02931 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P02931 IntAct P02931 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P02931* InterPro IPR001702 http://www.ebi.ac.uk/interpro/entry/IPR001702 InterPro IPR001897 http://www.ebi.ac.uk/interpro/entry/IPR001897 InterPro IPR013793 http://www.ebi.ac.uk/interpro/entry/IPR013793 InterPro IPR023614 http://www.ebi.ac.uk/interpro/entry/IPR023614 InterPro IPR033900 http://www.ebi.ac.uk/interpro/entry/IPR033900 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0912 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0912 KEGG_Gene eco:b0929 http://www.genome.jp/dbget-bin/www_bget?eco:b0929 KEGG_Orthology KO:K09476 http://www.genome.jp/dbget-bin/www_bget?KO:K09476 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 MINT MINT-1511804 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1511804 OMA YAINQID http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YAINQID PDB 1BT9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1BT9 PDB 1GFM http://www.ebi.ac.uk/pdbe-srv/view/entry/1GFM PDB 1GFN http://www.ebi.ac.uk/pdbe-srv/view/entry/1GFN PDB 1GFO http://www.ebi.ac.uk/pdbe-srv/view/entry/1GFO PDB 1GFP http://www.ebi.ac.uk/pdbe-srv/view/entry/1GFP PDB 1GFQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1GFQ PDB 1HXT http://www.ebi.ac.uk/pdbe-srv/view/entry/1HXT PDB 1HXU http://www.ebi.ac.uk/pdbe-srv/view/entry/1HXU PDB 1HXX http://www.ebi.ac.uk/pdbe-srv/view/entry/1HXX PDB 1MPF http://www.ebi.ac.uk/pdbe-srv/view/entry/1MPF PDB 1OPF http://www.ebi.ac.uk/pdbe-srv/view/entry/1OPF PDB 2OMF http://www.ebi.ac.uk/pdbe-srv/view/entry/2OMF PDB 2ZFG http://www.ebi.ac.uk/pdbe-srv/view/entry/2ZFG PDB 2ZLD http://www.ebi.ac.uk/pdbe-srv/view/entry/2ZLD PDB 3FYX http://www.ebi.ac.uk/pdbe-srv/view/entry/3FYX PDB 3HW9 http://www.ebi.ac.uk/pdbe-srv/view/entry/3HW9 PDB 3HWB http://www.ebi.ac.uk/pdbe-srv/view/entry/3HWB PDB 3K19 http://www.ebi.ac.uk/pdbe-srv/view/entry/3K19 PDB 3K1B http://www.ebi.ac.uk/pdbe-srv/view/entry/3K1B PDB 3O0E http://www.ebi.ac.uk/pdbe-srv/view/entry/3O0E PDB 3POQ http://www.ebi.ac.uk/pdbe-srv/view/entry/3POQ PDB 3POU http://www.ebi.ac.uk/pdbe-srv/view/entry/3POU PDB 3POX http://www.ebi.ac.uk/pdbe-srv/view/entry/3POX PDB 4D5U http://www.ebi.ac.uk/pdbe-srv/view/entry/4D5U PDB 4GCP http://www.ebi.ac.uk/pdbe-srv/view/entry/4GCP PDB 4GCQ http://www.ebi.ac.uk/pdbe-srv/view/entry/4GCQ PDB 4GCS http://www.ebi.ac.uk/pdbe-srv/view/entry/4GCS PDB 4JFB http://www.ebi.ac.uk/pdbe-srv/view/entry/4JFB PDB 4LSE http://www.ebi.ac.uk/pdbe-srv/view/entry/4LSE PDB 4LSF http://www.ebi.ac.uk/pdbe-srv/view/entry/4LSF PDB 4LSH http://www.ebi.ac.uk/pdbe-srv/view/entry/4LSH PDB 4LSI http://www.ebi.ac.uk/pdbe-srv/view/entry/4LSI PDBsum 1BT9 http://www.ebi.ac.uk/pdbsum/1BT9 PDBsum 1GFM http://www.ebi.ac.uk/pdbsum/1GFM PDBsum 1GFN http://www.ebi.ac.uk/pdbsum/1GFN PDBsum 1GFO http://www.ebi.ac.uk/pdbsum/1GFO PDBsum 1GFP http://www.ebi.ac.uk/pdbsum/1GFP PDBsum 1GFQ http://www.ebi.ac.uk/pdbsum/1GFQ PDBsum 1HXT http://www.ebi.ac.uk/pdbsum/1HXT PDBsum 1HXU http://www.ebi.ac.uk/pdbsum/1HXU PDBsum 1HXX http://www.ebi.ac.uk/pdbsum/1HXX PDBsum 1MPF http://www.ebi.ac.uk/pdbsum/1MPF PDBsum 1OPF http://www.ebi.ac.uk/pdbsum/1OPF PDBsum 2OMF http://www.ebi.ac.uk/pdbsum/2OMF PDBsum 2ZFG http://www.ebi.ac.uk/pdbsum/2ZFG PDBsum 2ZLD http://www.ebi.ac.uk/pdbsum/2ZLD PDBsum 3FYX http://www.ebi.ac.uk/pdbsum/3FYX PDBsum 3HW9 http://www.ebi.ac.uk/pdbsum/3HW9 PDBsum 3HWB http://www.ebi.ac.uk/pdbsum/3HWB PDBsum 3K19 http://www.ebi.ac.uk/pdbsum/3K19 PDBsum 3K1B http://www.ebi.ac.uk/pdbsum/3K1B PDBsum 3O0E http://www.ebi.ac.uk/pdbsum/3O0E PDBsum 3POQ http://www.ebi.ac.uk/pdbsum/3POQ PDBsum 3POU http://www.ebi.ac.uk/pdbsum/3POU PDBsum 3POX http://www.ebi.ac.uk/pdbsum/3POX PDBsum 4D5U http://www.ebi.ac.uk/pdbsum/4D5U PDBsum 4GCP http://www.ebi.ac.uk/pdbsum/4GCP PDBsum 4GCQ http://www.ebi.ac.uk/pdbsum/4GCQ PDBsum 4GCS http://www.ebi.ac.uk/pdbsum/4GCS PDBsum 4JFB http://www.ebi.ac.uk/pdbsum/4JFB PDBsum 4LSE http://www.ebi.ac.uk/pdbsum/4LSE PDBsum 4LSF http://www.ebi.ac.uk/pdbsum/4LSF PDBsum 4LSH http://www.ebi.ac.uk/pdbsum/4LSH PDBsum 4LSI http://www.ebi.ac.uk/pdbsum/4LSI PRINTS PR00182 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00182 PRINTS PR00183 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00183 PROSITE PS00576 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00576 PSORT swissprot:OMPF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:OMPF_ECOLI PSORT-B swissprot:OMPF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:OMPF_ECOLI PSORT2 swissprot:OMPF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:OMPF_ECOLI Pfam PF00267 http://pfam.xfam.org/family/PF00267 Phobius swissprot:OMPF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:OMPF_ECOLI PhylomeDB P02931 http://phylomedb.org/?seqid=P02931 ProteinModelPortal P02931 http://www.proteinmodelportal.org/query/uniprot/P02931 PubMed 1380671 http://www.ncbi.nlm.nih.gov/pubmed/1380671 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19721064 http://www.ncbi.nlm.nih.gov/pubmed/19721064 PubMed 2997131 http://www.ncbi.nlm.nih.gov/pubmed/2997131 PubMed 6294623 http://www.ncbi.nlm.nih.gov/pubmed/6294623 PubMed 7037455 http://www.ncbi.nlm.nih.gov/pubmed/7037455 PubMed 7049161 http://www.ncbi.nlm.nih.gov/pubmed/7049161 PubMed 7524100 http://www.ncbi.nlm.nih.gov/pubmed/7524100 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9629924 http://www.ncbi.nlm.nih.gov/pubmed/9629924 PubMed 9843370 http://www.ncbi.nlm.nih.gov/pubmed/9843370 RefSeq NP_415449 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415449 RefSeq WP_000977920 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000977920 SMR P02931 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P02931 STRING 511145.b0929 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0929&targetmode=cogs STRING COG3203 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3203&targetmode=cogs SWISS-2DPAGE P02931 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P02931 TCDB 1.B.1.1 http://www.tcdb.org/search/result.php?tc=1.B.1.1 UniProtKB OMPF_ECOLI http://www.uniprot.org/uniprot/OMPF_ECOLI UniProtKB-AC P02931 http://www.uniprot.org/uniprot/P02931 charge swissprot:OMPF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:OMPF_ECOLI eggNOG COG3203 http://eggnogapi.embl.de/nog_data/html/tree/COG3203 eggNOG ENOG4105FCK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FCK epestfind swissprot:OMPF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:OMPF_ECOLI garnier swissprot:OMPF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:OMPF_ECOLI helixturnhelix swissprot:OMPF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:OMPF_ECOLI hmoment swissprot:OMPF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:OMPF_ECOLI iep swissprot:OMPF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:OMPF_ECOLI inforesidue swissprot:OMPF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:OMPF_ECOLI octanol swissprot:OMPF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:OMPF_ECOLI pepcoil swissprot:OMPF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:OMPF_ECOLI pepdigest swissprot:OMPF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:OMPF_ECOLI pepinfo swissprot:OMPF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:OMPF_ECOLI pepnet swissprot:OMPF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:OMPF_ECOLI pepstats swissprot:OMPF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:OMPF_ECOLI pepwheel swissprot:OMPF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:OMPF_ECOLI pepwindow swissprot:OMPF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:OMPF_ECOLI sigcleave swissprot:OMPF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:OMPF_ECOLI ## Database ID URL or Descriptions # AltName YAHK_ECOLI Zinc-dependent alcohol dehydrogenase YahK # BIOPHYSICOCHEMICAL PROPERTIES YAHK_ECOLI Kinetic parameters KM=13.3 mM for acetaldehyde {ECO 0000269|PubMed 23093176}; KM=10.9 mM for propionaldehyde {ECO 0000269|PubMed 23093176}; KM=4.4 mM for glyceraldehyde {ECO 0000269|PubMed 23093176}; KM=2.1 mM for butyraldehyde {ECO 0000269|PubMed 23093176}; KM=2.2 mM for isobutyraldehyde {ECO 0000269|PubMed 23093176}; KM=3.6 mM for crotonaldehyde {ECO 0000269|PubMed 23093176}; KM=4.1 mM for glutaraldehyde {ECO 0000269|PubMed 23093176}; KM=52.6 mM for 5-hydroxyvalerate {ECO 0000269|PubMed 23093176}; KM=0.37 mM for hexanaldehyde {ECO 0000269|PubMed 23093176}; KM=0.29 mM for benzaldehyde {ECO 0000269|PubMed 23093176}; KM=0.135 mM for furfural {ECO 0000269|PubMed 23093176}; KM=6.6 mM for butanol {ECO 0000269|PubMed 23093176}; KM=38.5 mM for 1,4-butanediol {ECO 0000269|PubMed 23093176}; KM=0.011 mM for NADPH {ECO 0000269|PubMed 23093176}; KM=0.012 mM for NADP(+) {ECO 0000269|PubMed 23093176}; Note=kcat is 11.2 sec(-1) for acetaldehyde reduction. kcat is 11.6 sec(-1) for propionaldehyde reduction. kcat is 12.3 sec(-1) for glyceraldehyde reduction. kcat is 41.6 sec(-1) for butyraldehyde reduction. kcat is 32.1 sec(-1) for isobutyraldehyde reduction. kcat is 32.6 sec(-1) for crotonaldehyde reduction. kcat is 13.4 sec(-1) for glutaraldehyde reduction. kcat is 0.18 sec(-1) for 5- hydroxyvalerate reduction. kcat is 18.3 sec(-1) for hexanaldehyde reduction. kcat is 7.75 sec(-1) for benzaldehyde reduction. kcat is 12.5 sec(-1) for furfural reduction. kcat is 4.7 sec(-1) for butanol oxidation. kcat is 6.7 sec(-1) for 1,4- butanediol oxidation.; Temperature dependence Shows a constant increase in activity until 60 degrees Celsius using butyraldehyde as substrate. {ECO 0000269|PubMed 23093176}; # BioGrid 4259802 7 # CATALYTIC ACTIVITY An alcohol + NADP(+) = an aldehyde + NADPH. {ECO:0000269|PubMed 23093176}. # COFACTOR YAHK_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 22094925, ECO 0000269|Ref.6}; Note=Binds 2 Zn(2+) ions per subunit. {ECO 0000269|PubMed 22094925, ECO 0000269|Ref.6}; # EcoGene EG13595 yahK # FUNCTION YAHK_ECOLI Catalyzes the reduction of a wide range of aldehydes into their corresponding alcohols. Has a strong preference for NADPH over NADH as the electron donor. Cannot use a ketone as substrate. Is a major source of NADPH-dependent aldehyde reductase activity in E.coli. The in vivo functions of YahK has yet to be determined. {ECO 0000269|PubMed 23093176}. # GO_function GO:0008106 alcohol dehydrogenase (NADP+) activity; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IEA:InterPro. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.720 -; 1. # Gene3D 3.90.180.10 -; 1. # IntAct P75691 9 # InterPro IPR002085 ADH_SF_Zn-type # InterPro IPR002328 ADH_Zn_CS # InterPro IPR011032 GroES-like # InterPro IPR013149 ADH_C # InterPro IPR013154 ADH_N # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR020843 PKS_ER # InterPro IPR029752 D-isomer_DH_CS1 # KEGG_Brite ko01000 Enzymes # Organism YAHK_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11695 PTHR11695 # PATRIC 32115779 VBIEscCol129921_0332 # PDB 1UUF X-ray; 1.76 A; A=2-349 # PIR E64759 E64759 # PROSITE PS00059 ADH_ZINC # Pfam PF00107 ADH_zinc_N # Pfam PF08240 ADH_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAHK_ECOLI Aldehyde reductase YahK # RefSeq NP_414859 NC_000913.3 # RefSeq WP_000692754 NZ_LN832404.1 # SIMILARITY Belongs to the zinc-containing alcohol dehydrogenase family. {ECO 0000305}. # SMART SM00829 PKS_ER # SUPFAM SSF50129 SSF50129 # SUPFAM SSF51735 SSF51735 # eggNOG COG1064 LUCA # eggNOG ENOG4105DQ4 Bacteria BLAST swissprot:YAHK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAHK_ECOLI BioCyc ECOL316407:JW0317-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0317-MONOMER BioCyc EcoCyc:G6190-MONOMER http://biocyc.org/getid?id=EcoCyc:G6190-MONOMER BioCyc MetaCyc:G6190-MONOMER http://biocyc.org/getid?id=MetaCyc:G6190-MONOMER COG COG1064 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1064 DIP DIP-11263N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11263N DOI 10.1007/s00253-012-4474-5 http://dx.doi.org/10.1007/s00253-012-4474-5 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1039/c1mt00154j http://dx.doi.org/10.1039/c1mt00154j DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.2 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 ENZYME 1.1.1.2 http://enzyme.expasy.org/EC/1.1.1.2 EchoBASE EB3364 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3364 EcoGene EG13595 http://www.ecogene.org/geneInfo.php?eg_id=EG13595 EnsemblBacteria AAC73428 http://www.ensemblgenomes.org/id/AAC73428 EnsemblBacteria AAC73428 http://www.ensemblgenomes.org/id/AAC73428 EnsemblBacteria BAE76108 http://www.ensemblgenomes.org/id/BAE76108 EnsemblBacteria BAE76108 http://www.ensemblgenomes.org/id/BAE76108 EnsemblBacteria BAE76108 http://www.ensemblgenomes.org/id/BAE76108 EnsemblBacteria b0325 http://www.ensemblgenomes.org/id/b0325 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008106 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008106 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 Gene3D 3.90.180.10 http://www.cathdb.info/version/latest/superfamily/3.90.180.10 GeneID 944975 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944975 HOGENOM HOG000294667 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000294667&db=HOGENOM6 InParanoid P75691 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75691 IntAct P75691 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75691* IntEnz 1.1.1.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.2 InterPro IPR002085 http://www.ebi.ac.uk/interpro/entry/IPR002085 InterPro IPR002328 http://www.ebi.ac.uk/interpro/entry/IPR002328 InterPro IPR011032 http://www.ebi.ac.uk/interpro/entry/IPR011032 InterPro IPR013149 http://www.ebi.ac.uk/interpro/entry/IPR013149 InterPro IPR013154 http://www.ebi.ac.uk/interpro/entry/IPR013154 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR020843 http://www.ebi.ac.uk/interpro/entry/IPR020843 InterPro IPR029752 http://www.ebi.ac.uk/interpro/entry/IPR029752 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0317 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0317 KEGG_Gene eco:b0325 http://www.genome.jp/dbget-bin/www_bget?eco:b0325 KEGG_Orthology KO:K13979 http://www.genome.jp/dbget-bin/www_bget?KO:K13979 OMA YCTGGGM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YCTGGGM PANTHER PTHR11695 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11695 PDB 1UUF http://www.ebi.ac.uk/pdbe-srv/view/entry/1UUF PDBsum 1UUF http://www.ebi.ac.uk/pdbsum/1UUF PROSITE PS00059 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00059 PSORT swissprot:YAHK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAHK_ECOLI PSORT-B swissprot:YAHK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAHK_ECOLI PSORT2 swissprot:YAHK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAHK_ECOLI Pfam PF00107 http://pfam.xfam.org/family/PF00107 Pfam PF08240 http://pfam.xfam.org/family/PF08240 Phobius swissprot:YAHK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAHK_ECOLI PhylomeDB P75691 http://phylomedb.org/?seqid=P75691 ProteinModelPortal P75691 http://www.proteinmodelportal.org/query/uniprot/P75691 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22094925 http://www.ncbi.nlm.nih.gov/pubmed/22094925 PubMed 23093176 http://www.ncbi.nlm.nih.gov/pubmed/23093176 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414859 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414859 RefSeq WP_000692754 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000692754 SMART SM00829 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00829 SMR P75691 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75691 STRING 511145.b0325 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0325&targetmode=cogs STRING COG1064 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1064&targetmode=cogs SUPFAM SSF50129 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50129 SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 SWISS-2DPAGE P75691 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P75691 UniProtKB YAHK_ECOLI http://www.uniprot.org/uniprot/YAHK_ECOLI UniProtKB-AC P75691 http://www.uniprot.org/uniprot/P75691 charge swissprot:YAHK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAHK_ECOLI eggNOG COG1064 http://eggnogapi.embl.de/nog_data/html/tree/COG1064 eggNOG ENOG4105DQ4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DQ4 epestfind swissprot:YAHK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAHK_ECOLI garnier swissprot:YAHK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAHK_ECOLI helixturnhelix swissprot:YAHK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAHK_ECOLI hmoment swissprot:YAHK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAHK_ECOLI iep swissprot:YAHK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAHK_ECOLI inforesidue swissprot:YAHK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAHK_ECOLI octanol swissprot:YAHK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAHK_ECOLI pepcoil swissprot:YAHK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAHK_ECOLI pepdigest swissprot:YAHK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAHK_ECOLI pepinfo swissprot:YAHK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAHK_ECOLI pepnet swissprot:YAHK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAHK_ECOLI pepstats swissprot:YAHK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAHK_ECOLI pepwheel swissprot:YAHK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAHK_ECOLI pepwindow swissprot:YAHK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAHK_ECOLI sigcleave swissprot:YAHK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAHK_ECOLI ## Database ID URL or Descriptions # BioGrid 4260086 165 # DOMAIN MFD_ECOLI Consists of a compact arrangement of structured domains linked by long, flexible linkers. The N-terminal region interacts with UvrA, the central region interacts with RNAP, and the C- terminal DNA translocase region possesses ATPase activity. Activity is regulated by a conformational switch from a dormant closed state to an active open state upon substrate binding. {ECO 0000269|PubMed 16309703, ECO 0000269|PubMed 16469698, ECO 0000269|PubMed 19700770, ECO 0000269|PubMed 22331906, ECO 0000269|PubMed 7876261}. # EcoGene EG11619 mfd # FUNCTION MFD_ECOLI Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site. Can also dissociate RNAP that is blocked by low concentration of nucleoside triphosphates or by physical obstruction, such as bound proteins. In addition, can rescue arrested complexes by promoting forward translocation. Has ATPase activity, which is required for removal of stalled RNAP, but seems to lack helicase activity. May act through a translocase activity that rewinds upstream DNA, leading either to translocation or to release of RNAP when the enzyme active site cannot continue elongation. {ECO 0000255|HAMAP-Rule MF_00969, ECO 0000269|PubMed 12086674, ECO 0000269|PubMed 19700770, ECO 0000269|PubMed 7876261, ECO 0000269|PubMed 7876262, ECO 0000269|PubMed 8465200}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0003684 damaged DNA binding; IEA:InterPro. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008026 ATP-dependent helicase activity; IDA:EcoCyc. # GO_function GO:0015616 DNA translocase activity; IDA:EcoCyc. # GO_function GO:0043175 RNA polymerase core enzyme binding; IDA:EcoCyc. # GO_process GO:0000716 transcription-coupled nucleotide-excision repair, DNA damage recognition; IDA:EcoCyc. # GO_process GO:0006281 DNA repair; IMP:EcoliWiki. # GO_process GO:0006355 regulation of transcription, DNA-templated; IDA:EcoliWiki. # GO_process GO:0006974 cellular response to DNA damage stimulus; IDA:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004386 helicase activity # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0019899 enzyme binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0051276 chromosome organization # Gene3D 3.40.50.300 -; 2. # HAMAP MF_00969 TRCF # INTERACTION MFD_ECOLI P0A698 uvrA; NbExp=2; IntAct=EBI-554211, EBI-552091; # IntAct P30958 17 # InterPro IPR001650 Helicase_C # InterPro IPR003711 CarD-like/TRCF_domain # InterPro IPR004576 Mfd # InterPro IPR005118 TRCF_C # InterPro IPR011545 DEAD/DEAH_box_helicase_dom # InterPro IPR014001 Helicase_ATP-bd # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko03420 Nucleotide excision repair # Organism MFD_ECOLI Escherichia coli (strain K12) # PATRIC 32117471 VBIEscCol129921_1158 # PDB 2B2N X-ray; 2.10 A; A/B=1-333 # PDB 2EYQ X-ray; 3.20 A; A/B=1-1148 # PDB 3HJH X-ray; 1.95 A; A=1-470 # PDB 4DFC X-ray; 2.80 A; A/C=127-213 # PIR G64855 G64855 # PROSITE PS51192 HELICASE_ATP_BIND_1 # PROSITE PS51194 HELICASE_CTER # Pfam PF00270 DEAD # Pfam PF00271 Helicase_C # Pfam PF02559 CarD_CdnL_TRCF # Pfam PF03461 TRCF # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Transcription-repair-coupling factor {ECO:0000255|HAMAP-Rule MF_00969} # RefSeq NP_415632 NC_000913.3 # RefSeq WP_001115094 NZ_LN832404.1 # SIMILARITY Contains 1 helicase ATP-binding domain. {ECO:0000255|HAMAP-Rule MF_00969}. # SIMILARITY Contains 1 helicase C-terminal domain. {ECO:0000255|HAMAP-Rule MF_00969}. # SIMILARITY In the C-terminal section; belongs to the helicase family. RecG subfamily. {ECO:0000255|HAMAP-Rule MF_00969}. # SIMILARITY In the N-terminal section; belongs to the UvrB family. {ECO:0000255|HAMAP-Rule MF_00969}. # SMART SM00487 DEXDc # SMART SM00490 HELICc # SMART SM00982 TRCF # SMART SM01058 CarD_TRCF # SUBCELLULAR LOCATION MFD_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00969}. # SUBUNIT MFD_ECOLI Monomer. Interacts with UvrA and RNAP. {ECO 0000269|PubMed 12086674, ECO 0000269|PubMed 22331906, ECO 0000269|PubMed 7876261, ECO 0000269|PubMed 8465200}. # SUPFAM SSF141259 SSF141259 # SUPFAM SSF52540 SSF52540; 4 # TIGRFAMs TIGR00580 mfd # eggNOG COG1197 LUCA # eggNOG ENOG4108JA2 Bacteria BLAST swissprot:MFD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MFD_ECOLI BioCyc ECOL316407:JW1100-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1100-MONOMER BioCyc EcoCyc:EG11619-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11619-MONOMER COG COG1197 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1197 DIP DIP-10199N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10199N DOI 10.1016/S0092-8674(02)00769-9 http://dx.doi.org/10.1016/S0092-8674(02)00769-9 DOI 10.1016/j.cell.2005.11.045 http://dx.doi.org/10.1016/j.cell.2005.11.045 DOI 10.1016/j.jmb.2005.10.033 http://dx.doi.org/10.1016/j.jmb.2005.10.033 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.1115105109 http://dx.doi.org/10.1073/pnas.1115105109 DOI 10.1074/jbc.270.9.4882 http://dx.doi.org/10.1074/jbc.270.9.4882 DOI 10.1074/jbc.270.9.4890 http://dx.doi.org/10.1074/jbc.270.9.4890 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/gkp680 http://dx.doi.org/10.1093/nar/gkp680 DOI 10.1107/S1744309105035876 http://dx.doi.org/10.1107/S1744309105035876 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1126/science.8465200 http://dx.doi.org/10.1126/science.8465200 EC_number EC:3.6.4.- {ECO:0000255|HAMAP-Rule:MF_00969} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.4.- {ECO:0000255|HAMAP-Rule:MF_00969} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.6.4.- {ECO:0000255|HAMAP-Rule:MF_00969} http://enzyme.expasy.org/EC/3.6.4.- {ECO:0000255|HAMAP-Rule:MF_00969} EchoBASE EB1576 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1576 EcoGene EG11619 http://www.ecogene.org/geneInfo.php?eg_id=EG11619 EnsemblBacteria AAC74198 http://www.ensemblgenomes.org/id/AAC74198 EnsemblBacteria AAC74198 http://www.ensemblgenomes.org/id/AAC74198 EnsemblBacteria BAA35929 http://www.ensemblgenomes.org/id/BAA35929 EnsemblBacteria BAA35929 http://www.ensemblgenomes.org/id/BAA35929 EnsemblBacteria BAA35929 http://www.ensemblgenomes.org/id/BAA35929 EnsemblBacteria b1114 http://www.ensemblgenomes.org/id/b1114 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003684 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003684 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008026 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008026 GO_function GO:0015616 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015616 GO_function GO:0043175 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043175 GO_process GO:0000716 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000716 GO_process GO:0006281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006281 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004386 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0019899 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0051276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051276 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945681 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945681 HAMAP MF_00969 http://hamap.expasy.org/unirule/MF_00969 HOGENOM HOG000216592 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000216592&db=HOGENOM6 InParanoid P30958 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30958 IntAct P30958 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P30958* IntEnz 3.6.4.- {ECO:0000255|HAMAP-Rule:MF_00969} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.4.- {ECO:0000255|HAMAP-Rule:MF_00969} InterPro IPR001650 http://www.ebi.ac.uk/interpro/entry/IPR001650 InterPro IPR003711 http://www.ebi.ac.uk/interpro/entry/IPR003711 InterPro IPR004576 http://www.ebi.ac.uk/interpro/entry/IPR004576 InterPro IPR005118 http://www.ebi.ac.uk/interpro/entry/IPR005118 InterPro IPR011545 http://www.ebi.ac.uk/interpro/entry/IPR011545 InterPro IPR014001 http://www.ebi.ac.uk/interpro/entry/IPR014001 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW1100 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1100 KEGG_Gene eco:b1114 http://www.genome.jp/dbget-bin/www_bget?eco:b1114 KEGG_Orthology KO:K03723 http://www.genome.jp/dbget-bin/www_bget?KO:K03723 KEGG_Pathway ko03420 http://www.genome.jp/kegg-bin/show_pathway?ko03420 MINT MINT-1231460 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1231460 OMA GTHKLIQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GTHKLIQ PDB 2B2N http://www.ebi.ac.uk/pdbe-srv/view/entry/2B2N PDB 2EYQ http://www.ebi.ac.uk/pdbe-srv/view/entry/2EYQ PDB 3HJH http://www.ebi.ac.uk/pdbe-srv/view/entry/3HJH PDB 4DFC http://www.ebi.ac.uk/pdbe-srv/view/entry/4DFC PDBsum 2B2N http://www.ebi.ac.uk/pdbsum/2B2N PDBsum 2EYQ http://www.ebi.ac.uk/pdbsum/2EYQ PDBsum 3HJH http://www.ebi.ac.uk/pdbsum/3HJH PDBsum 4DFC http://www.ebi.ac.uk/pdbsum/4DFC PROSITE PS51192 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51192 PROSITE PS51194 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51194 PSORT swissprot:MFD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MFD_ECOLI PSORT-B swissprot:MFD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MFD_ECOLI PSORT2 swissprot:MFD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MFD_ECOLI Pfam PF00270 http://pfam.xfam.org/family/PF00270 Pfam PF00271 http://pfam.xfam.org/family/PF00271 Pfam PF02559 http://pfam.xfam.org/family/PF02559 Pfam PF03461 http://pfam.xfam.org/family/PF03461 Phobius swissprot:MFD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MFD_ECOLI PhylomeDB P30958 http://phylomedb.org/?seqid=P30958 ProteinModelPortal P30958 http://www.proteinmodelportal.org/query/uniprot/P30958 PubMed 12086674 http://www.ncbi.nlm.nih.gov/pubmed/12086674 PubMed 16309703 http://www.ncbi.nlm.nih.gov/pubmed/16309703 PubMed 16469698 http://www.ncbi.nlm.nih.gov/pubmed/16469698 PubMed 16511235 http://www.ncbi.nlm.nih.gov/pubmed/16511235 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19700770 http://www.ncbi.nlm.nih.gov/pubmed/19700770 PubMed 22331906 http://www.ncbi.nlm.nih.gov/pubmed/22331906 PubMed 7876261 http://www.ncbi.nlm.nih.gov/pubmed/7876261 PubMed 7876262 http://www.ncbi.nlm.nih.gov/pubmed/7876262 PubMed 8465200 http://www.ncbi.nlm.nih.gov/pubmed/8465200 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415632 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415632 RefSeq WP_001115094 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001115094 SMART SM00487 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00487 SMART SM00490 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00490 SMART SM00982 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00982 SMART SM01058 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01058 SMR P30958 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P30958 STRING 511145.b1114 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1114&targetmode=cogs STRING COG1197 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1197&targetmode=cogs SUPFAM SSF141259 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF141259 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR00580 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00580 UniProtKB MFD_ECOLI http://www.uniprot.org/uniprot/MFD_ECOLI UniProtKB-AC P30958 http://www.uniprot.org/uniprot/P30958 charge swissprot:MFD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MFD_ECOLI eggNOG COG1197 http://eggnogapi.embl.de/nog_data/html/tree/COG1197 eggNOG ENOG4108JA2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108JA2 epestfind swissprot:MFD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MFD_ECOLI garnier swissprot:MFD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MFD_ECOLI helixturnhelix swissprot:MFD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MFD_ECOLI hmoment swissprot:MFD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MFD_ECOLI iep swissprot:MFD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MFD_ECOLI inforesidue swissprot:MFD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MFD_ECOLI octanol swissprot:MFD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MFD_ECOLI pepcoil swissprot:MFD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MFD_ECOLI pepdigest swissprot:MFD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MFD_ECOLI pepinfo swissprot:MFD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MFD_ECOLI pepnet swissprot:MFD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MFD_ECOLI pepstats swissprot:MFD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MFD_ECOLI pepwheel swissprot:MFD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MFD_ECOLI pepwindow swissprot:MFD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MFD_ECOLI sigcleave swissprot:MFD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MFD_ECOLI ## Database ID URL or Descriptions # FUNCTION TRAL1_ECOLI Membrane protein involved in F pilin formation. # GO_component GO:0009279 cell outer membrane; IEA:UniProtKB-SubCell. # GO_process GO:0000746 conjugation; IEA:UniProtKB-KW. # GO_process GO:0009297 pilus assembly; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0008150 biological_process # GOslim_process GO:0022607 cellular component assembly # InterPro IPR009838 T4SS_TraL # InterPro IPR016382 Pilus_assmbly_TraL # Organism TRAL1_ECOLI Escherichia coli (strain K12) # PIR S03311 BVECTL # PIRSF PIRSF003259 Pilus_assembly_TraL # Pfam PF07178 TraL # RecName TRAL1_ECOLI Protein TraL # RefSeq NP_061454 NC_002483.1 # SEQUENCE CAUTION Sequence=CAA31974.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SUBCELLULAR LOCATION TRAL1_ECOLI Cell outer membrane. # TIGRFAMs TIGR02762 TraL_TIGR BLAST swissprot:TRAL1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRAL1_ECOLI DOI 10.1093/nar/17.4.1283 http://dx.doi.org/10.1093/nar/17.4.1283 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL K01147 http://www.ebi.ac.uk/ena/data/view/K01147 EMBL U01159 http://www.ebi.ac.uk/ena/data/view/U01159 EMBL U51860 http://www.ebi.ac.uk/ena/data/view/U51860 EMBL X13681 http://www.ebi.ac.uk/ena/data/view/X13681 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_process GO:0000746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000746 GO_process GO:0009297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009297 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GeneID 1263564 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263564 InterPro IPR009838 http://www.ebi.ac.uk/interpro/entry/IPR009838 InterPro IPR016382 http://www.ebi.ac.uk/interpro/entry/IPR016382 OMA CYWHLPS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CYWHLPS PSORT swissprot:TRAL1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRAL1_ECOLI PSORT-B swissprot:TRAL1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRAL1_ECOLI PSORT2 swissprot:TRAL1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRAL1_ECOLI Pfam PF07178 http://pfam.xfam.org/family/PF07178 Phobius swissprot:TRAL1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRAL1_ECOLI ProteinModelPortal P08321 http://www.proteinmodelportal.org/query/uniprot/P08321 PubMed 2564189 http://www.ncbi.nlm.nih.gov/pubmed/2564189 PubMed 6090426 http://www.ncbi.nlm.nih.gov/pubmed/6090426 PubMed 7915817 http://www.ncbi.nlm.nih.gov/pubmed/7915817 PubMed 8655498 http://www.ncbi.nlm.nih.gov/pubmed/8655498 RefSeq NP_061454 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061454 TIGRFAMs TIGR02762 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02762 UniProtKB TRAL1_ECOLI http://www.uniprot.org/uniprot/TRAL1_ECOLI UniProtKB-AC P08321 http://www.uniprot.org/uniprot/P08321 charge swissprot:TRAL1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRAL1_ECOLI epestfind swissprot:TRAL1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRAL1_ECOLI garnier swissprot:TRAL1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRAL1_ECOLI helixturnhelix swissprot:TRAL1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRAL1_ECOLI hmoment swissprot:TRAL1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRAL1_ECOLI iep swissprot:TRAL1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRAL1_ECOLI inforesidue swissprot:TRAL1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRAL1_ECOLI octanol swissprot:TRAL1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRAL1_ECOLI pepcoil swissprot:TRAL1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRAL1_ECOLI pepdigest swissprot:TRAL1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRAL1_ECOLI pepinfo swissprot:TRAL1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRAL1_ECOLI pepnet swissprot:TRAL1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRAL1_ECOLI pepstats swissprot:TRAL1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRAL1_ECOLI pepwheel swissprot:TRAL1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRAL1_ECOLI pepwindow swissprot:TRAL1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRAL1_ECOLI sigcleave swissprot:TRAL1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRAL1_ECOLI ## Database ID URL or Descriptions # AltName RNLA_ECOLI RNase LS # AltName RNLA_ECOLI Toxin LS # BioGrid 4259437 12 # DISRUPTION PHENOTYPE RNLA_ECOLI Not essential, slightly smaller colonies on minimal agar plates at 30 degrees Celsius. Strongly reduces RNase LS activity, restores growth of an enterobacteria phage T4 dmd mutant. Altered mRNA half-life for some cellular transcripts, including an increased half-life for an internal fragment of 23S rRNA. Allele rnlA2 is due to a premature stop codon at residue 33 (PubMed 15677746). Sensitive to high concentrations of NaCl, sensitivity is eliminated in a crp or cyaA deletion mutant. Increased levels of Crp and thus increased levels of cAMP. {ECO 0000269|PubMed 15677746, ECO 0000269|PubMed 19019153}. # EcoGene EG13200 rnlA # FUNCTION RNLA_ECOLI Toxic component of a toxin-antitoxin (TA) module. A stable (half-life 27.6 minutes) endoribonuclease that in the absence of cognate antitoxin RnlB causes generalized RNA degradation. Degrades late enterobacteria phage T4 mRNAs, protecting the host against T4 reproduction. Activity is inhibited by cognate antitoxin RnlB and by enterobacteria phage T4 protein Dmd. Targets cyaA mRNA. {ECO 0000269|PubMed 17895580, ECO 0000269|PubMed 19019153, ECO 0000269|PubMed 20980243, ECO 0000269|PubMed 22403819}. # GO_function GO:0004521 endoribonuclease activity; IDA:EcoCyc. # GO_process GO:0006402 mRNA catabolic process; IMP:EcoCyc. # GOslim_function GO:0004518 nuclease activity # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # INDUCTION Repressed by IscR. rnlA-rnlB forms an operon, the downstream rnlB also has its own promoter. {ECO:0000269|PubMed 20421606}. # IntAct P52129 2 # InterPro IPR031845 RnlA_toxin # Organism RNLA_ECOLI Escherichia coli (strain K12) # PATRIC 32120651 VBIEscCol129921_2724 # PDB 4I8O X-ray; 2.10 A; A/B=1-357 # PIR H65041 H65041 # Pfam PF15935 RnlA_toxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RNLA_ECOLI mRNA endoribonuclease LS # RefSeq NP_417119 NC_000913.3 # RefSeq WP_000155570 NZ_LN832404.1 # SUBUNIT RNLA_ECOLI Can form a complex with cognate antitoxin RnlB and with enterobacteria phage T4 antitoxin Dmd. # eggNOG ENOG4106K8T Bacteria # eggNOG ENOG410YAX4 LUCA BLAST swissprot:RNLA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RNLA_ECOLI BioCyc ECOL316407:JW2611-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2611-MONOMER BioCyc EcoCyc:G7365-MONOMER http://biocyc.org/getid?id=EcoCyc:G7365-MONOMER BioCyc MetaCyc:G7365-MONOMER http://biocyc.org/getid?id=MetaCyc:G7365-MONOMER DIP DIP-12079N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12079N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2008.06504.x http://dx.doi.org/10.1111/j.1365-2958.2008.06504.x DOI 10.1111/j.1365-2958.2012.07975.x http://dx.doi.org/10.1111/j.1365-2958.2012.07975.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1266/ggs.82.291 http://dx.doi.org/10.1266/ggs.82.291 DOI 10.1534/genetics.104.033290 http://dx.doi.org/10.1534/genetics.104.033290 DOI 10.1534/genetics.110.114462 http://dx.doi.org/10.1534/genetics.110.114462 DOI 10.1534/genetics.110.121798 http://dx.doi.org/10.1534/genetics.110.121798 EC_number EC:3.1.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36840 http://www.ebi.ac.uk/ena/data/view/U36840 ENZYME 3.1.-.- http://enzyme.expasy.org/EC/3.1.-.- EchoBASE EB2992 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2992 EcoGene EG13200 http://www.ecogene.org/geneInfo.php?eg_id=EG13200 EnsemblBacteria AAC75678 http://www.ensemblgenomes.org/id/AAC75678 EnsemblBacteria AAC75678 http://www.ensemblgenomes.org/id/AAC75678 EnsemblBacteria BAE76765 http://www.ensemblgenomes.org/id/BAE76765 EnsemblBacteria BAE76765 http://www.ensemblgenomes.org/id/BAE76765 EnsemblBacteria BAE76765 http://www.ensemblgenomes.org/id/BAE76765 EnsemblBacteria b2630 http://www.ensemblgenomes.org/id/b2630 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004521 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004521 GO_process GO:0006402 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006402 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 GeneID 947107 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947107 HOGENOM HOG000012167 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000012167&db=HOGENOM6 IntAct P52129 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P52129* IntEnz 3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1 InterPro IPR031845 http://www.ebi.ac.uk/interpro/entry/IPR031845 KEGG_Gene ecj:JW2611 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2611 KEGG_Gene eco:b2630 http://www.genome.jp/dbget-bin/www_bget?eco:b2630 MINT MINT-1290895 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1290895 OMA CYRAFIF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CYRAFIF PDB 4I8O http://www.ebi.ac.uk/pdbe-srv/view/entry/4I8O PDBsum 4I8O http://www.ebi.ac.uk/pdbsum/4I8O PSORT swissprot:RNLA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RNLA_ECOLI PSORT-B swissprot:RNLA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RNLA_ECOLI PSORT2 swissprot:RNLA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RNLA_ECOLI Pfam PF15935 http://pfam.xfam.org/family/PF15935 Phobius swissprot:RNLA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RNLA_ECOLI ProteinModelPortal P52129 http://www.proteinmodelportal.org/query/uniprot/P52129 PubMed 15677746 http://www.ncbi.nlm.nih.gov/pubmed/15677746 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17895580 http://www.ncbi.nlm.nih.gov/pubmed/17895580 PubMed 19019153 http://www.ncbi.nlm.nih.gov/pubmed/19019153 PubMed 20421606 http://www.ncbi.nlm.nih.gov/pubmed/20421606 PubMed 20980243 http://www.ncbi.nlm.nih.gov/pubmed/20980243 PubMed 22403819 http://www.ncbi.nlm.nih.gov/pubmed/22403819 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417119 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417119 RefSeq WP_000155570 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000155570 SMR P52129 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P52129 STRING 511145.b2630 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2630&targetmode=cogs UniProtKB RNLA_ECOLI http://www.uniprot.org/uniprot/RNLA_ECOLI UniProtKB-AC P52129 http://www.uniprot.org/uniprot/P52129 charge swissprot:RNLA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RNLA_ECOLI eggNOG ENOG4106K8T http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106K8T eggNOG ENOG410YAX4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YAX4 epestfind swissprot:RNLA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RNLA_ECOLI garnier swissprot:RNLA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RNLA_ECOLI helixturnhelix swissprot:RNLA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RNLA_ECOLI hmoment swissprot:RNLA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RNLA_ECOLI iep swissprot:RNLA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RNLA_ECOLI inforesidue swissprot:RNLA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RNLA_ECOLI octanol swissprot:RNLA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RNLA_ECOLI pepcoil swissprot:RNLA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RNLA_ECOLI pepdigest swissprot:RNLA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RNLA_ECOLI pepinfo swissprot:RNLA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RNLA_ECOLI pepnet swissprot:RNLA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RNLA_ECOLI pepstats swissprot:RNLA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RNLA_ECOLI pepwheel swissprot:RNLA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RNLA_ECOLI pepwindow swissprot:RNLA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RNLA_ECOLI sigcleave swissprot:RNLA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RNLA_ECOLI ## Database ID URL or Descriptions # AltName FPG_ECOLI DNA-(apurinic or apyrimidinic site) lyase MutM # BRENDA 3.2.2.23 2026 # BioGrid 4262563 107 # CATALYTIC ACTIVITY FPG_ECOLI Hydrolysis of DNA containing ring-opened 7- methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N- methyl)formamidopyrimidine. # CATALYTIC ACTIVITY FPG_ECOLI The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. # COFACTOR FPG_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 1689309}; Note=Binds 1 zinc ion per subunit. {ECO 0000269|PubMed 1689309}; # DOMAIN FPG_ECOLI The zinc-finger is necessary for DNA binding. # EcoGene EG10329 mutM # FUNCTION FPG_ECOLI Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG) and its derivatives such as guanidinohydantoin C and spiroiminodihydantoin C, however it also acts on thymine glycol G, 5,6-dihydrouracil G and 5-hydroxyuracil G. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Cleaves ssDNA containing an AP site. {ECO 0000269|PubMed 1689309, ECO 0000269|PubMed 20031487}. # GO_function GO:0000703 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity; IDA:EcoCyc. # GO_function GO:0003684 damaged DNA binding; IDA:EcoliWiki. # GO_function GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity; IDA:EcoliWiki. # GO_function GO:0004519 endonuclease activity; IDA:EcoliWiki. # GO_function GO:0008270 zinc ion binding; IDA:EcoliWiki. # GO_function GO:0008534 oxidized purine nucleobase lesion DNA N-glycosylase activity; IDA:EcoCyc. # GO_function GO:0019104 DNA N-glycosylase activity; IDA:EcoliWiki. # GO_function GO:0046872 metal ion binding; IDA:EcoliWiki. # GO_process GO:0006285 base-excision repair, AP site formation; IDA:EcoCyc. # GO_process GO:0006289 nucleotide-excision repair; IEA:InterPro. # GO_process GO:0006974 cellular response to DNA damage stimulus; IDA:EcoliWiki. # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004518 nuclease activity # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # HAMAP MF_00103 Fapy_DNA_glycosyl # IntAct P05523 12 # InterPro IPR000214 Znf_DNA_glyclase/AP_lyase # InterPro IPR010663 Znf_FPG/IleRS # InterPro IPR010979 Ribosomal_S13-like_H2TH # InterPro IPR012319 FPG_cat # InterPro IPR015886 DNA_glyclase/AP_lyase_DNA-bd # InterPro IPR015887 DNA_glyclase_Znf_dom_DNA_BS # InterPro IPR020629 Formamido-pyr_DNA_Glyclase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko03410 Base excision repair # Organism FPG_ECOLI Escherichia coli (strain K12) # PATRIC 32122757 VBIEscCol129921_3755 # PDB 1K82 X-ray; 2.10 A; A/B/C/D=2-269 # PIR A30254 DGECFP # PROSITE PS01242 ZF_FPG_1 # PROSITE PS51066 ZF_FPG_2 # PROSITE PS51068 FPG_CAT # Pfam PF01149 Fapy_DNA_glyco # Pfam PF06827 zf-FPG_IleRS # Pfam PF06831 H2TH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FPG_ECOLI Formamidopyrimidine-DNA glycosylase # RefSeq NP_418092 NC_000913.3 # RefSeq WP_001114543 NZ_LN832404.1 # SIMILARITY Belongs to the FPG family. {ECO 0000305}. # SIMILARITY Contains 1 FPG-type zinc finger. {ECO 0000305}. # SMART SM00898 Fapy_DNA_glyco # SMART SM01232 H2TH # SUBUNIT FPG_ECOLI Monomer. {ECO 0000269|PubMed 11912217, ECO 0000269|PubMed 1689309}. # SUPFAM SSF46946 SSF46946 # SUPFAM SSF81624 SSF81624 # TIGRFAMs TIGR00577 fpg # eggNOG COG0266 LUCA # eggNOG ENOG4105ERD Bacteria BLAST swissprot:FPG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FPG_ECOLI BioCyc ECOL316407:JW3610-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3610-MONOMER BioCyc EcoCyc:EG10329-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10329-MONOMER BioCyc MetaCyc:EG10329-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10329-MONOMER COG COG0266 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0266 DIP DIP-10286N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10286N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1016/j.dnarep.2009.11.008 http://dx.doi.org/10.1016/j.dnarep.2009.11.008 DOI 10.1021/bi001587x http://dx.doi.org/10.1021/bi001587x DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M202058200 http://dx.doi.org/10.1074/jbc.M202058200 DOI 10.1074/jbc.M310262200 http://dx.doi.org/10.1074/jbc.M310262200 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.2.2.23 http://www.genome.jp/dbget-bin/www_bget?EC:3.2.2.23 EC_number EC:4.2.99.18 http://www.genome.jp/dbget-bin/www_bget?EC:4.2.99.18 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M60670 http://www.ebi.ac.uk/ena/data/view/M60670 EMBL M86305 http://www.ebi.ac.uk/ena/data/view/M86305 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X06036 http://www.ebi.ac.uk/ena/data/view/X06036 ENZYME 3.2.2.23 http://enzyme.expasy.org/EC/3.2.2.23 ENZYME 4.2.99.18 http://enzyme.expasy.org/EC/4.2.99.18 EchoBASE EB0325 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0325 EcoGene EG10329 http://www.ecogene.org/geneInfo.php?eg_id=EG10329 EnsemblBacteria AAC76659 http://www.ensemblgenomes.org/id/AAC76659 EnsemblBacteria AAC76659 http://www.ensemblgenomes.org/id/AAC76659 EnsemblBacteria BAE77657 http://www.ensemblgenomes.org/id/BAE77657 EnsemblBacteria BAE77657 http://www.ensemblgenomes.org/id/BAE77657 EnsemblBacteria BAE77657 http://www.ensemblgenomes.org/id/BAE77657 EnsemblBacteria b3635 http://www.ensemblgenomes.org/id/b3635 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000703 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000703 GO_function GO:0003684 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003684 GO_function GO:0003906 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003906 GO_function GO:0004519 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004519 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0008534 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008534 GO_function GO:0019104 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019104 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006285 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006285 GO_process GO:0006289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006289 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 946765 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946765 HAMAP MF_00103 http://hamap.expasy.org/unirule/MF_00103 HOGENOM HOG000020881 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000020881&db=HOGENOM6 InParanoid P05523 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P05523 IntAct P05523 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P05523* IntEnz 3.2.2.23 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.2.2.23 IntEnz 4.2.99.18 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.99.18 InterPro IPR000214 http://www.ebi.ac.uk/interpro/entry/IPR000214 InterPro IPR010663 http://www.ebi.ac.uk/interpro/entry/IPR010663 InterPro IPR010979 http://www.ebi.ac.uk/interpro/entry/IPR010979 InterPro IPR012319 http://www.ebi.ac.uk/interpro/entry/IPR012319 InterPro IPR015886 http://www.ebi.ac.uk/interpro/entry/IPR015886 InterPro IPR015887 http://www.ebi.ac.uk/interpro/entry/IPR015887 InterPro IPR020629 http://www.ebi.ac.uk/interpro/entry/IPR020629 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW3610 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3610 KEGG_Gene eco:b3635 http://www.genome.jp/dbget-bin/www_bget?eco:b3635 KEGG_Orthology KO:K10563 http://www.genome.jp/dbget-bin/www_bget?KO:K10563 KEGG_Pathway ko03410 http://www.genome.jp/kegg-bin/show_pathway?ko03410 OMA DGWIIVH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DGWIIVH PDB 1K82 http://www.ebi.ac.uk/pdbe-srv/view/entry/1K82 PDBsum 1K82 http://www.ebi.ac.uk/pdbsum/1K82 PROSITE PS01242 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01242 PROSITE PS51066 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51066 PROSITE PS51068 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51068 PSORT swissprot:FPG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FPG_ECOLI PSORT-B swissprot:FPG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FPG_ECOLI PSORT2 swissprot:FPG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FPG_ECOLI Pfam PF01149 http://pfam.xfam.org/family/PF01149 Pfam PF06827 http://pfam.xfam.org/family/PF06827 Pfam PF06831 http://pfam.xfam.org/family/PF06831 Phobius swissprot:FPG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FPG_ECOLI PhylomeDB P05523 http://phylomedb.org/?seqid=P05523 ProteinModelPortal P05523 http://www.proteinmodelportal.org/query/uniprot/P05523 PubMed 11106507 http://www.ncbi.nlm.nih.gov/pubmed/11106507 PubMed 11912217 http://www.ncbi.nlm.nih.gov/pubmed/11912217 PubMed 14607836 http://www.ncbi.nlm.nih.gov/pubmed/14607836 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1689309 http://www.ncbi.nlm.nih.gov/pubmed/1689309 PubMed 20031487 http://www.ncbi.nlm.nih.gov/pubmed/20031487 PubMed 2033061 http://www.ncbi.nlm.nih.gov/pubmed/2033061 PubMed 3319582 http://www.ncbi.nlm.nih.gov/pubmed/3319582 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 8473347 http://www.ncbi.nlm.nih.gov/pubmed/8473347 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418092 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418092 RefSeq WP_001114543 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001114543 SMART SM00898 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00898 SMART SM01232 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01232 SMR P05523 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P05523 STRING 511145.b3635 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3635&targetmode=cogs STRING COG0266 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0266&targetmode=cogs SUPFAM SSF46946 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46946 SUPFAM SSF81624 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81624 TIGRFAMs TIGR00577 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00577 UniProtKB FPG_ECOLI http://www.uniprot.org/uniprot/FPG_ECOLI UniProtKB-AC P05523 http://www.uniprot.org/uniprot/P05523 charge swissprot:FPG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FPG_ECOLI eggNOG COG0266 http://eggnogapi.embl.de/nog_data/html/tree/COG0266 eggNOG ENOG4105ERD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ERD epestfind swissprot:FPG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FPG_ECOLI garnier swissprot:FPG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FPG_ECOLI helixturnhelix swissprot:FPG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FPG_ECOLI hmoment swissprot:FPG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FPG_ECOLI iep swissprot:FPG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FPG_ECOLI inforesidue swissprot:FPG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FPG_ECOLI octanol swissprot:FPG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FPG_ECOLI pepcoil swissprot:FPG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FPG_ECOLI pepdigest swissprot:FPG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FPG_ECOLI pepinfo swissprot:FPG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FPG_ECOLI pepnet swissprot:FPG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FPG_ECOLI pepstats swissprot:FPG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FPG_ECOLI pepwheel swissprot:FPG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FPG_ECOLI pepwindow swissprot:FPG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FPG_ECOLI sigcleave swissprot:FPG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FPG_ECOLI ## Database ID URL or Descriptions # CAUTION May be the product of a pseudogene; it has numerous changes compared to other insH genes. {ECO 0000305}. # EcoGene EG40008 insH5 # FUNCTION INSH5_ECOLI Involved in the transposition of the insertion sequence IS5. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0032196 transposition # InterPro IPR002559 Transposase_11 # InterPro IPR008490 Transposase_InsH_N # Organism INSH5_ECOLI Escherichia coli (strain K12) # PATRIC 32118014 VBIEscCol129921_1427 # PIR E64887 E64887 # PIR T09186 T09186 # Pfam PF01609 DDE_Tnp_1 # Pfam PF05598 DUF772 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSH5_ECOLI Transposase InsH for insertion sequence element IS5Y # RefSeq WP_000019448 NZ_CP011343.2 # SIMILARITY Belongs to the transposase 11 family. {ECO 0000305}. # eggNOG COG3039 LUCA # eggNOG ENOG4105F2I Bacteria BLAST swissprot:INSH5_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSH5_ECOLI BioCyc ECOL316407:JW1363-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1363-MONOMER BioCyc EcoCyc:G6693-MONOMER http://biocyc.org/getid?id=EcoCyc:G6693-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4723 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4723 EcoGene EG40008 http://www.ecogene.org/geneInfo.php?eg_id=EG40008 EnsemblBacteria BAA14963 http://www.ensemblgenomes.org/id/BAA14963 EnsemblBacteria BAA14963 http://www.ensemblgenomes.org/id/BAA14963 EnsemblBacteria BAA14963 http://www.ensemblgenomes.org/id/BAA14963 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 HOGENOM HOG000002547 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000002547&db=HOGENOM6 InParanoid P76071 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76071 InterPro IPR002559 http://www.ebi.ac.uk/interpro/entry/IPR002559 InterPro IPR008490 http://www.ebi.ac.uk/interpro/entry/IPR008490 KEGG_Gene ecj:JW1363 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1363 OMA CETMLRI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CETMLRI PSORT swissprot:INSH5_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSH5_ECOLI PSORT-B swissprot:INSH5_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSH5_ECOLI PSORT2 swissprot:INSH5_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSH5_ECOLI Pfam PF01609 http://pfam.xfam.org/family/PF01609 Pfam PF05598 http://pfam.xfam.org/family/PF05598 Phobius swissprot:INSH5_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSH5_ECOLI PhylomeDB P76071 http://phylomedb.org/?seqid=P76071 ProteinModelPortal P76071 http://www.proteinmodelportal.org/query/uniprot/P76071 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000019448 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000019448 STRING 511145.b1370 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1370&targetmode=cogs UniProtKB INSH5_ECOLI http://www.uniprot.org/uniprot/INSH5_ECOLI UniProtKB-AC P76071 http://www.uniprot.org/uniprot/P76071 charge swissprot:INSH5_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSH5_ECOLI eggNOG COG3039 http://eggnogapi.embl.de/nog_data/html/tree/COG3039 eggNOG ENOG4105F2I http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F2I epestfind swissprot:INSH5_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSH5_ECOLI garnier swissprot:INSH5_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSH5_ECOLI helixturnhelix swissprot:INSH5_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSH5_ECOLI hmoment swissprot:INSH5_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSH5_ECOLI iep swissprot:INSH5_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSH5_ECOLI inforesidue swissprot:INSH5_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSH5_ECOLI octanol swissprot:INSH5_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSH5_ECOLI pepcoil swissprot:INSH5_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSH5_ECOLI pepdigest swissprot:INSH5_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSH5_ECOLI pepinfo swissprot:INSH5_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSH5_ECOLI pepnet swissprot:INSH5_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSH5_ECOLI pepstats swissprot:INSH5_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSH5_ECOLI pepwheel swissprot:INSH5_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSH5_ECOLI pepwindow swissprot:INSH5_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSH5_ECOLI sigcleave swissprot:INSH5_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSH5_ECOLI ## Database ID URL or Descriptions # AltName CARA_ECOLI Carbamoyl-phosphate synthetase glutamine chain # BioGrid 4263445 6 # CATALYTIC ACTIVITY CARA_ECOLI 2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate. # EcoGene EG10134 carA # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0005951 carbamoyl-phosphate synthase complex; IDA:EcoCyc. # GO_function GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; IEA:UniProtKB-HAMAP. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_process GO:0000050 urea cycle; IBA:GO_Central. # GO_process GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process; IMP:EcoliWiki. # GO_process GO:0006526 arginine biosynthetic process; IMP:EcoliWiki. # GO_process GO:0006541 glutamine metabolic process; IMP:EcoliWiki. # GO_process GO:0044205 'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0071941 nitrogen cycle metabolic process # Gene3D 3.40.50.880 -; 1. # Gene3D 3.50.30.20 -; 1. # HAMAP MF_01209 CPSase_S_chain # INTERACTION CARA_ECOLI P00968 carB; NbExp=11; IntAct=EBI-546107, EBI-546118; P0AD21 yejG; NbExp=2; IntAct=EBI-546107, EBI-1127956; # IntAct P0A6F1 16 # InterPro IPR002474 CarbamoylP_synth_ssu_N # InterPro IPR006274 CarbamoylP_synth_ssu # InterPro IPR017926 GATASE # InterPro IPR029062 Class_I_gatase-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00240 Pyrimidine metabolism # KEGG_Pathway ko00250 Alanine, aspartate and glutamate metabolism # Organism CARA_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate step 1/1. # PATHWAY Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate step 1/3. # PATRIC 32115157 VBIEscCol129921_0030 # PDB 1A9X X-ray; 1.80 A; B/D/F/H=2-380 # PDB 1BXR X-ray; 2.10 A; B/D/F/H=1-382 # PDB 1C30 X-ray; 2.00 A; B/D/F/H=1-382 # PDB 1C3O X-ray; 2.10 A; B/D/F/H=1-382 # PDB 1CE8 X-ray; 2.10 A; B/D/F/H=1-380 # PDB 1CS0 X-ray; 2.00 A; B/D/F/H=1-382 # PDB 1JDB X-ray; 2.10 A; C/F/I/L=1-382 # PDB 1KEE X-ray; 2.10 A; B/D/F/H=1-382 # PDB 1M6V X-ray; 2.10 A; B/D/F/H=1-382 # PDB 1T36 X-ray; 2.10 A; B/D/F/H=1-382 # PIR A01128 SYECCS # PIR B85484 B85484 # PROSITE PS51273 GATASE_TYPE_1 # Pfam PF00117 GATase # Pfam PF00988 CPSase_sm_chain # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CARA_ECOLI Carbamoyl-phosphate synthase small chain # RefSeq NP_414573 NC_000913.3 # RefSeq WP_000597260 NZ_LN832404.1 # SIMILARITY Belongs to the CarA family. {ECO 0000305}. # SIMILARITY Contains 1 glutamine amidotransferase type-1 domain. {ECO 0000305}. # SMART SM01097 CPSase_sm_chain # SUBUNIT CARA_ECOLI Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. Tetramer of heterodimers (alpha,beta)4. # SUPFAM SSF52021 SSF52021 # SUPFAM SSF52317 SSF52317 # TIGRFAMs TIGR01368 CPSaseIIsmall # UniPathway UPA00068 UER00171 # UniPathway UPA00070 UER00115 # eggNOG COG0505 LUCA # eggNOG ENOG4105C1M Bacteria BLAST swissprot:CARA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CARA_ECOLI BioCyc ECOL316407:JW0030-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0030-MONOMER BioCyc EcoCyc:CARBPSYN-SMALL http://biocyc.org/getid?id=EcoCyc:CARBPSYN-SMALL BioCyc MetaCyc:CARBPSYN-SMALL http://biocyc.org/getid?id=MetaCyc:CARBPSYN-SMALL COG COG0505 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0505 DIP DIP-35412N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35412N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1021/bi970503q http://dx.doi.org/10.1021/bi970503q DOI 10.1021/bi9807761 http://dx.doi.org/10.1021/bi9807761 DOI 10.1021/bi982517h http://dx.doi.org/10.1021/bi982517h DOI 10.1021/bi991741j http://dx.doi.org/10.1021/bi991741j DOI 10.1038/360606a0 http://dx.doi.org/10.1038/360606a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.80.15.4629 http://dx.doi.org/10.1073/pnas.80.15.4629 DOI 10.1073/pnas.81.13.4134 http://dx.doi.org/10.1073/pnas.81.13.4134 DOI 10.1073/pnas.81.13.4139 http://dx.doi.org/10.1073/pnas.81.13.4139 DOI 10.1074/jbc.274.32.22502 http://dx.doi.org/10.1074/jbc.274.32.22502 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1107/S0907444998006234 http://dx.doi.org/10.1107/S0907444998006234 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.3.5.5 http://www.genome.jp/dbget-bin/www_bget?EC:6.3.5.5 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01597 http://www.ebi.ac.uk/ena/data/view/J01597 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X70017 http://www.ebi.ac.uk/ena/data/view/X70017 ENZYME 6.3.5.5 http://enzyme.expasy.org/EC/6.3.5.5 EchoBASE EB0132 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0132 EcoGene EG10134 http://www.ecogene.org/geneInfo.php?eg_id=EG10134 EnsemblBacteria AAC73143 http://www.ensemblgenomes.org/id/AAC73143 EnsemblBacteria AAC73143 http://www.ensemblgenomes.org/id/AAC73143 EnsemblBacteria BAB96601 http://www.ensemblgenomes.org/id/BAB96601 EnsemblBacteria BAB96601 http://www.ensemblgenomes.org/id/BAB96601 EnsemblBacteria BAB96601 http://www.ensemblgenomes.org/id/BAB96601 EnsemblBacteria b0032 http://www.ensemblgenomes.org/id/b0032 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005951 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005951 GO_function GO:0004088 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004088 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0000050 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000050 GO_process GO:0006207 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006207 GO_process GO:0006526 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006526 GO_process GO:0006541 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006541 GO_process GO:0044205 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044205 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0071941 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071941 Gene3D 3.40.50.880 http://www.cathdb.info/version/latest/superfamily/3.40.50.880 Gene3D 3.50.30.20 http://www.cathdb.info/version/latest/superfamily/3.50.30.20 GeneID 949025 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949025 HAMAP MF_01209 http://hamap.expasy.org/unirule/MF_01209 HOGENOM HOG000038087 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000038087&db=HOGENOM6 InParanoid P0A6F1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6F1 IntAct P0A6F1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6F1* IntEnz 6.3.5.5 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.5.5 InterPro IPR002474 http://www.ebi.ac.uk/interpro/entry/IPR002474 InterPro IPR006274 http://www.ebi.ac.uk/interpro/entry/IPR006274 InterPro IPR017926 http://www.ebi.ac.uk/interpro/entry/IPR017926 InterPro IPR029062 http://www.ebi.ac.uk/interpro/entry/IPR029062 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0030 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0030 KEGG_Gene eco:b0032 http://www.genome.jp/dbget-bin/www_bget?eco:b0032 KEGG_Orthology KO:K01956 http://www.genome.jp/dbget-bin/www_bget?KO:K01956 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Pathway ko00250 http://www.genome.jp/kegg-bin/show_pathway?ko00250 KEGG_Reaction rn:R00575 http://www.genome.jp/dbget-bin/www_bget?rn:R00575 OMA CFSVQYH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CFSVQYH PDB 1A9X http://www.ebi.ac.uk/pdbe-srv/view/entry/1A9X PDB 1BXR http://www.ebi.ac.uk/pdbe-srv/view/entry/1BXR PDB 1C30 http://www.ebi.ac.uk/pdbe-srv/view/entry/1C30 PDB 1C3O http://www.ebi.ac.uk/pdbe-srv/view/entry/1C3O PDB 1CE8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1CE8 PDB 1CS0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1CS0 PDB 1JDB http://www.ebi.ac.uk/pdbe-srv/view/entry/1JDB PDB 1KEE http://www.ebi.ac.uk/pdbe-srv/view/entry/1KEE PDB 1M6V http://www.ebi.ac.uk/pdbe-srv/view/entry/1M6V PDB 1T36 http://www.ebi.ac.uk/pdbe-srv/view/entry/1T36 PDBsum 1A9X http://www.ebi.ac.uk/pdbsum/1A9X PDBsum 1BXR http://www.ebi.ac.uk/pdbsum/1BXR PDBsum 1C30 http://www.ebi.ac.uk/pdbsum/1C30 PDBsum 1C3O http://www.ebi.ac.uk/pdbsum/1C3O PDBsum 1CE8 http://www.ebi.ac.uk/pdbsum/1CE8 PDBsum 1CS0 http://www.ebi.ac.uk/pdbsum/1CS0 PDBsum 1JDB http://www.ebi.ac.uk/pdbsum/1JDB PDBsum 1KEE http://www.ebi.ac.uk/pdbsum/1KEE PDBsum 1M6V http://www.ebi.ac.uk/pdbsum/1M6V PDBsum 1T36 http://www.ebi.ac.uk/pdbsum/1T36 PROSITE PS51273 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51273 PSORT swissprot:CARA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CARA_ECOLI PSORT-B swissprot:CARA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CARA_ECOLI PSORT2 swissprot:CARA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CARA_ECOLI Pfam PF00117 http://pfam.xfam.org/family/PF00117 Pfam PF00988 http://pfam.xfam.org/family/PF00988 Phobius swissprot:CARA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CARA_ECOLI PhylomeDB P0A6F1 http://phylomedb.org/?seqid=P0A6F1 ProteinModelPortal P0A6F1 http://www.proteinmodelportal.org/query/uniprot/P0A6F1 PubMed 10029528 http://www.ncbi.nlm.nih.gov/pubmed/10029528 PubMed 10089390 http://www.ncbi.nlm.nih.gov/pubmed/10089390 PubMed 10428826 http://www.ncbi.nlm.nih.gov/pubmed/10428826 PubMed 10587438 http://www.ncbi.nlm.nih.gov/pubmed/10587438 PubMed 1334233 http://www.ncbi.nlm.nih.gov/pubmed/1334233 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6308632 http://www.ncbi.nlm.nih.gov/pubmed/6308632 PubMed 6330744 http://www.ncbi.nlm.nih.gov/pubmed/6330744 PubMed 6377309 http://www.ncbi.nlm.nih.gov/pubmed/6377309 PubMed 9174345 http://www.ncbi.nlm.nih.gov/pubmed/9174345 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9636022 http://www.ncbi.nlm.nih.gov/pubmed/9636022 RefSeq NP_414573 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414573 RefSeq WP_000597260 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000597260 SMART SM01097 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01097 SMR P0A6F1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6F1 STRING 511145.b0032 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0032&targetmode=cogs STRING COG0505 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0505&targetmode=cogs SUPFAM SSF52021 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52021 SUPFAM SSF52317 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52317 SWISS-2DPAGE P0A6F1 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A6F1 TIGRFAMs TIGR01368 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01368 UniProtKB CARA_ECOLI http://www.uniprot.org/uniprot/CARA_ECOLI UniProtKB-AC P0A6F1 http://www.uniprot.org/uniprot/P0A6F1 charge swissprot:CARA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CARA_ECOLI eggNOG COG0505 http://eggnogapi.embl.de/nog_data/html/tree/COG0505 eggNOG ENOG4105C1M http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C1M epestfind swissprot:CARA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CARA_ECOLI garnier swissprot:CARA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CARA_ECOLI helixturnhelix swissprot:CARA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CARA_ECOLI hmoment swissprot:CARA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CARA_ECOLI iep swissprot:CARA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CARA_ECOLI inforesidue swissprot:CARA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CARA_ECOLI octanol swissprot:CARA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CARA_ECOLI pepcoil swissprot:CARA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CARA_ECOLI pepdigest swissprot:CARA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CARA_ECOLI pepinfo swissprot:CARA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CARA_ECOLI pepnet swissprot:CARA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CARA_ECOLI pepstats swissprot:CARA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CARA_ECOLI pepwheel swissprot:CARA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CARA_ECOLI pepwindow swissprot:CARA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CARA_ECOLI sigcleave swissprot:CARA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CARA_ECOLI ## Database ID URL or Descriptions # AltName COBC_ECOLI Adenosylcobalamin phosphatase # AltName COBC_ECOLI Alpha-ribazole-5'-phosphate phosphatase # CATALYTIC ACTIVITY Adenosylcobalamin 5'-phosphate + H(2)O = coenzyme B12 + phosphate. {ECO:0000250|UniProtKB P39701}. # CATALYTIC ACTIVITY Alpha-ribazole 5'-phosphate + H(2)O = alpha- ribazole + phosphate. {ECO:0000250|UniProtKB P39701}. # CDD cd07067 HP_PGM_like # EcoGene EG13240 cobC # FUNCTION COBC_ECOLI Catalyzes the conversion of adenosylcobalamin 5'- phosphate to adenosylcobalamin (vitamin B12); involved in the assembly of the nucleotide loop of cobalamin. Also catalyzes the hydrolysis of the phospho group from alpha-ribazole 5'-phosphate to form alpha-ribazole. {ECO 0000250|UniProtKB P39701}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0016791 phosphatase activity; IBA:GO_Central. # GO_function GO:0043755 alpha-ribazole phosphatase activity; IEA:UniProtKB-EC. # GO_process GO:0009236 cobalamin biosynthetic process; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016791 phosphatase activity # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.1240 -; 1. # IntAct P52086 3 # InterPro IPR001345 PG/BPGM_mutase_AS # InterPro IPR013078 His_Pase_superF_clade-1 # InterPro IPR017578 Ribazole_CobC # InterPro IPR029033 His_PPase_superfam # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00860 Porphyrin and chlorophyll metabolism # Organism COBC_ECOLI Escherichia coli (strain K12) # PATHWAY Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole step 2/2. # PATRIC 32116459 VBIEscCol129921_0669 # PIR D64798 D64798 # PROSITE PS00175 PG_MUTASE # Pfam PF00300 His_Phos_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName COBC_ECOLI Adenosylcobalamin/alpha-ribazole phosphatase # RefSeq NP_415171 NC_000913.3 # RefSeq WP_001241872 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40839.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the phosphoglycerate mutase family. {ECO 0000305}. # SMART SM00855 PGAM # SUPFAM SSF53254 SSF53254 # TIGRFAMs TIGR03162 ribazole_cobC # UniPathway UPA00061 UER00517 # eggNOG COG0406 LUCA # eggNOG ENOG4108TGR Bacteria BLAST swissprot:COBC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:COBC_ECOLI BioCyc ECOL316407:JW0633-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0633-MONOMER BioCyc EcoCyc:RIBAZOLEPHOSPHAT-MONOMER http://biocyc.org/getid?id=EcoCyc:RIBAZOLEPHOSPHAT-MONOMER BioCyc MetaCyc:RIBAZOLEPHOSPHAT-MONOMER http://biocyc.org/getid?id=MetaCyc:RIBAZOLEPHOSPHAT-MONOMER COG COG0406 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0406 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.3.73 {ECO:0000250|UniProtKB:P39701} http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.73 {ECO:0000250|UniProtKB:P39701} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U23163 http://www.ebi.ac.uk/ena/data/view/U23163 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 ENZYME 3.1.3.73 {ECO:0000250|UniProtKB:P39701} http://enzyme.expasy.org/EC/3.1.3.73 {ECO:0000250|UniProtKB:P39701} EchoBASE EB3029 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3029 EcoGene EG13240 http://www.ecogene.org/geneInfo.php?eg_id=EG13240 EnsemblBacteria AAC73739 http://www.ensemblgenomes.org/id/AAC73739 EnsemblBacteria AAC73739 http://www.ensemblgenomes.org/id/AAC73739 EnsemblBacteria BAA35285 http://www.ensemblgenomes.org/id/BAA35285 EnsemblBacteria BAA35285 http://www.ensemblgenomes.org/id/BAA35285 EnsemblBacteria BAA35285 http://www.ensemblgenomes.org/id/BAA35285 EnsemblBacteria b0638 http://www.ensemblgenomes.org/id/b0638 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GO_function GO:0043755 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043755 GO_process GO:0009236 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009236 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.1240 http://www.cathdb.info/version/latest/superfamily/3.40.50.1240 GeneID 945246 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945246 HOGENOM HOG000221683 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000221683&db=HOGENOM6 InParanoid P52086 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P52086 IntAct P52086 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P52086* IntEnz 3.1.3.73 {ECO:0000250|UniProtKB:P39701} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.73 {ECO:0000250|UniProtKB:P39701} InterPro IPR001345 http://www.ebi.ac.uk/interpro/entry/IPR001345 InterPro IPR013078 http://www.ebi.ac.uk/interpro/entry/IPR013078 InterPro IPR017578 http://www.ebi.ac.uk/interpro/entry/IPR017578 InterPro IPR029033 http://www.ebi.ac.uk/interpro/entry/IPR029033 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0633 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0633 KEGG_Gene eco:b0638 http://www.genome.jp/dbget-bin/www_bget?eco:b0638 KEGG_Orthology KO:K02226 http://www.genome.jp/dbget-bin/www_bget?KO:K02226 KEGG_Pathway ko00860 http://www.genome.jp/kegg-bin/show_pathway?ko00860 KEGG_Reaction rn:R04594 http://www.genome.jp/dbget-bin/www_bget?rn:R04594 OMA EVERSHC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EVERSHC PROSITE PS00175 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00175 PSORT swissprot:COBC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:COBC_ECOLI PSORT-B swissprot:COBC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:COBC_ECOLI PSORT2 swissprot:COBC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:COBC_ECOLI Pfam PF00300 http://pfam.xfam.org/family/PF00300 Phobius swissprot:COBC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:COBC_ECOLI PhylomeDB P52086 http://phylomedb.org/?seqid=P52086 ProteinModelPortal P52086 http://www.proteinmodelportal.org/query/uniprot/P52086 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415171 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415171 RefSeq WP_001241872 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001241872 SMART SM00855 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00855 SMR P52086 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P52086 STRING 511145.b0638 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0638&targetmode=cogs STRING COG0406 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0406&targetmode=cogs SUPFAM SSF53254 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53254 TIGRFAMs TIGR03162 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03162 UniProtKB COBC_ECOLI http://www.uniprot.org/uniprot/COBC_ECOLI UniProtKB-AC P52086 http://www.uniprot.org/uniprot/P52086 charge swissprot:COBC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:COBC_ECOLI eggNOG COG0406 http://eggnogapi.embl.de/nog_data/html/tree/COG0406 eggNOG ENOG4108TGR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108TGR epestfind swissprot:COBC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:COBC_ECOLI garnier swissprot:COBC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:COBC_ECOLI helixturnhelix swissprot:COBC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:COBC_ECOLI hmoment swissprot:COBC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:COBC_ECOLI iep swissprot:COBC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:COBC_ECOLI inforesidue swissprot:COBC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:COBC_ECOLI octanol swissprot:COBC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:COBC_ECOLI pepcoil swissprot:COBC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:COBC_ECOLI pepdigest swissprot:COBC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:COBC_ECOLI pepinfo swissprot:COBC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:COBC_ECOLI pepnet swissprot:COBC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:COBC_ECOLI pepstats swissprot:COBC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:COBC_ECOLI pepwheel swissprot:COBC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:COBC_ECOLI pepwindow swissprot:COBC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:COBC_ECOLI sigcleave swissprot:COBC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:COBC_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES PUUD_ECOLI Kinetic parameters KM=2.93 mM for gamma-glutamyl-gamma-aminobutyrate {ECO 0000269|PubMed 15590624, ECO 0000269|PubMed 16499623}; KM=18.5 mM for gamma-glutamylputrescine {ECO 0000269|PubMed 15590624, ECO 0000269|PubMed 16499623}; pH dependence Optimum pH is between 8.5 and 9. {ECO 0000269|PubMed 15590624, ECO 0000269|PubMed 16499623}; # BRENDA 3.5.1.94 2165 # BioGrid 4260141 29 # CATALYTIC ACTIVITY 4-(gamma-L-glutamylamino)butanoate + H(2)O = 4-aminobutanoate + L-glutamate. {ECO:0000269|PubMed 15590624}. # DISRUPTION PHENOTYPE Cells lose the hydrolase activity. {ECO:0000269|PubMed 15590624}. # EcoGene EG13909 puuD # FUNCTION PUUD_ECOLI Involved in the breakdown of putrescine via hydrolysis of the gamma-glutamyl linkage of gamma-glutamyl-gamma- aminobutyrate. {ECO 0000269|PubMed 15590624, ECO 0000269|PubMed 16499623}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0033969 gamma-glutamyl-gamma-aminobutyrate hydrolase activity; IDA:EcoCyc. # GO_process GO:0006541 glutamine metabolic process; IEA:InterPro. # GO_process GO:0009447 putrescine catabolic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.50.880 -; 1. # INDUCTION PUUD_ECOLI Induced by putrescine and nutrient starvation. Repressed by PuuR and low aeration condition. Repressed at the exponential phase and highly induced in early stationary phase. {ECO 0000269|PubMed 15590624, ECO 0000269|PubMed 16499623}. # InterPro IPR011697 Peptidase_C26 # InterPro IPR017926 GATASE # InterPro IPR029062 Class_I_gatase-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # KEGG_Pathway ko00330 Arginine and proline metabolism # Organism PUUD_ECOLI Escherichia coli (strain K12) # PATHWAY Amine and polyamine degradation; putrescine degradation; 4-aminobutanoate from putrescine step 4/4. # PATRIC 32117868 VBIEscCol129921_1354 # PIR E64878 E64878 # PROSITE PS51273 GATASE_TYPE_1 # Pfam PF07722 Peptidase_C26 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PUUD_ECOLI Gamma-glutamyl-gamma-aminobutyrate hydrolase PuuD # RefSeq NP_415814 NC_000913.3 # RefSeq WP_001300506 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase C26 family. {ECO 0000305}. # SIMILARITY Contains 1 glutamine amidotransferase type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00605}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 16499623}. # SUPFAM SSF52317 SSF52317 # UniPathway UPA00188 UER00883 # eggNOG COG2071 LUCA # eggNOG ENOG4108Z86 Bacteria BLAST swissprot:PUUD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PUUD_ECOLI BioCyc ECOL316407:JW1291-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1291-MONOMER BioCyc EcoCyc:G6645-MONOMER http://biocyc.org/getid?id=EcoCyc:G6645-MONOMER BioCyc MetaCyc:G6645-MONOMER http://biocyc.org/getid?id=MetaCyc:G6645-MONOMER COG COG2071 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2071 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M411114200 http://dx.doi.org/10.1074/jbc.M411114200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1111/j.1574-6968.2006.00137.x http://dx.doi.org/10.1111/j.1574-6968.2006.00137.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.5.1.94 http://www.genome.jp/dbget-bin/www_bget?EC:3.5.1.94 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.5.1.94 http://enzyme.expasy.org/EC/3.5.1.94 EchoBASE EB3668 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3668 EcoGene EG13909 http://www.ecogene.org/geneInfo.php?eg_id=EG13909 EnsemblBacteria AAC74380 http://www.ensemblgenomes.org/id/AAC74380 EnsemblBacteria AAC74380 http://www.ensemblgenomes.org/id/AAC74380 EnsemblBacteria BAA14858 http://www.ensemblgenomes.org/id/BAA14858 EnsemblBacteria BAA14858 http://www.ensemblgenomes.org/id/BAA14858 EnsemblBacteria BAA14858 http://www.ensemblgenomes.org/id/BAA14858 EnsemblBacteria b1298 http://www.ensemblgenomes.org/id/b1298 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0033969 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033969 GO_process GO:0006541 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006541 GO_process GO:0009447 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009447 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.50.880 http://www.cathdb.info/version/latest/superfamily/3.40.50.880 GeneID 945882 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945882 HOGENOM HOG000035715 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000035715&db=HOGENOM6 InParanoid P76038 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76038 IntAct P76038 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76038* IntEnz 3.5.1.94 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.1.94 InterPro IPR011697 http://www.ebi.ac.uk/interpro/entry/IPR011697 InterPro IPR017926 http://www.ebi.ac.uk/interpro/entry/IPR017926 InterPro IPR029062 http://www.ebi.ac.uk/interpro/entry/IPR029062 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW1291 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1291 KEGG_Gene eco:b1298 http://www.genome.jp/dbget-bin/www_bget?eco:b1298 KEGG_Orthology KO:K09473 http://www.genome.jp/dbget-bin/www_bget?KO:K09473 KEGG_Pathway ko00330 http://www.genome.jp/kegg-bin/show_pathway?ko00330 KEGG_Reaction rn:R07419 http://www.genome.jp/dbget-bin/www_bget?rn:R07419 OMA GFITACR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GFITACR PROSITE PS51273 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51273 PSORT swissprot:PUUD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PUUD_ECOLI PSORT-B swissprot:PUUD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PUUD_ECOLI PSORT2 swissprot:PUUD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PUUD_ECOLI Pfam PF07722 http://pfam.xfam.org/family/PF07722 Phobius swissprot:PUUD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PUUD_ECOLI PhylomeDB P76038 http://phylomedb.org/?seqid=P76038 ProteinModelPortal P76038 http://www.proteinmodelportal.org/query/uniprot/P76038 PubMed 15590624 http://www.ncbi.nlm.nih.gov/pubmed/15590624 PubMed 16499623 http://www.ncbi.nlm.nih.gov/pubmed/16499623 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415814 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415814 RefSeq WP_001300506 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300506 SMR P76038 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76038 STRING 511145.b1298 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1298&targetmode=cogs STRING COG2071 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2071&targetmode=cogs SUPFAM SSF52317 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52317 UniProtKB PUUD_ECOLI http://www.uniprot.org/uniprot/PUUD_ECOLI UniProtKB-AC P76038 http://www.uniprot.org/uniprot/P76038 charge swissprot:PUUD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PUUD_ECOLI eggNOG COG2071 http://eggnogapi.embl.de/nog_data/html/tree/COG2071 eggNOG ENOG4108Z86 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Z86 epestfind swissprot:PUUD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PUUD_ECOLI garnier swissprot:PUUD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PUUD_ECOLI helixturnhelix swissprot:PUUD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PUUD_ECOLI hmoment swissprot:PUUD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PUUD_ECOLI iep swissprot:PUUD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PUUD_ECOLI inforesidue swissprot:PUUD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PUUD_ECOLI octanol swissprot:PUUD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PUUD_ECOLI pepcoil swissprot:PUUD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PUUD_ECOLI pepdigest swissprot:PUUD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PUUD_ECOLI pepinfo swissprot:PUUD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PUUD_ECOLI pepnet swissprot:PUUD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PUUD_ECOLI pepstats swissprot:PUUD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PUUD_ECOLI pepwheel swissprot:PUUD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PUUD_ECOLI pepwindow swissprot:PUUD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PUUD_ECOLI sigcleave swissprot:PUUD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PUUD_ECOLI ## Database ID URL or Descriptions # AltName ACUI_ECOLI Acryloyl-coenzyme A reductase AcuI # BioGrid 4261942 8 # CATALYTIC ACTIVITY ACUI_ECOLI Propanoyl-CoA + NADP(+) = acrylyl-CoA + NADPH. # DISRUPTION PHENOTYPE 100-fold increased sensitivity to acrylate, about 8-fold increased sensitivity to 3-hydroxypropionate. Acrylate is bacteriostatic, not bacteriocidal. Can be complemented by acuI from a number of other bacteria, including Rhodobacter sphaeroides strain 2.4.1 (AC Q3J6K9) and Ruegeria pomeyroi (AC Q5LS56). {ECO:0000269|PubMed 22563425}. # EcoGene EG11315 acuI # FUNCTION ACUI_ECOLI Probably catalyzes the NADPH-dependent reduction of acrylyl-CoA to propanoyl-CoA. {ECO 0000269|PubMed 22563425}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0008270 zinc ion binding; IEA:InterPro. # GO_function GO:0043957 acryloyl-CoA reductase (NADP+) activity; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.720 -; 1. # Gene3D 3.90.180.10 -; 1. # IntAct P26646 6 # InterPro IPR002085 ADH_SF_Zn-type # InterPro IPR011032 GroES-like # InterPro IPR013149 ADH_C # InterPro IPR013154 ADH_N # InterPro IPR014188 Acrylyl-CoA_reductase_AcuI # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR020843 PKS_ER # MISCELLANEOUS ACUI_ECOLI The zinc-binding residues of the alcohol dehydrogenase family are not conserved. # Organism ACUI_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11695 PTHR11695 # PANTHER PTHR11695:SF13 PTHR11695:SF13 # PATRIC 32121932 VBIEscCol129921_3350 # PDB 1O89 X-ray; 2.25 A; A=2-324 # PDB 1O8C X-ray; 2.60 A; A/B/C/D=2-324 # PIR JS0688 JS0688 # Pfam PF00107 ADH_zinc_N # Pfam PF08240 ADH_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ACUI_ECOLI Probable acrylyl-CoA reductase AcuI # RefSeq NP_417719 NC_000913.3 # RefSeq WP_001148481 NZ_LN832404.1 # SIMILARITY Belongs to the zinc-containing alcohol dehydrogenase family. Acrylyl-CoA reductase subfamily. {ECO 0000305}. # SMART SM00829 PKS_ER # SUBCELLULAR LOCATION ACUI_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 15388933}. # SUPFAM SSF50129 SSF50129 # SUPFAM SSF51735 SSF51735 # TIGRFAMs TIGR02823 oxido_YhdH # eggNOG COG0604 LUCA # eggNOG ENOG4105D3Z Bacteria BLAST swissprot:ACUI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ACUI_ECOLI BioCyc ECOL316407:JW3222-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3222-MONOMER BioCyc EcoCyc:EG11315-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11315-MONOMER BioCyc MetaCyc:EG11315-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11315-MONOMER DIP DIP-12295N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12295N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1107/S0907444904020220 http://dx.doi.org/10.1107/S0907444904020220 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pone.0035947 http://dx.doi.org/10.1371/journal.pone.0035947 EC_number EC:1.3.1.84 http://www.genome.jp/dbget-bin/www_bget?EC:1.3.1.84 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M80458 http://www.ebi.ac.uk/ena/data/view/M80458 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 1.3.1.84 http://enzyme.expasy.org/EC/1.3.1.84 EchoBASE EB1291 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1291 EcoGene EG11315 http://www.ecogene.org/geneInfo.php?eg_id=EG11315 EnsemblBacteria AAC76285 http://www.ensemblgenomes.org/id/AAC76285 EnsemblBacteria AAC76285 http://www.ensemblgenomes.org/id/AAC76285 EnsemblBacteria BAE77295 http://www.ensemblgenomes.org/id/BAE77295 EnsemblBacteria BAE77295 http://www.ensemblgenomes.org/id/BAE77295 EnsemblBacteria BAE77295 http://www.ensemblgenomes.org/id/BAE77295 EnsemblBacteria b3253 http://www.ensemblgenomes.org/id/b3253 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0043957 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043957 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 Gene3D 3.90.180.10 http://www.cathdb.info/version/latest/superfamily/3.90.180.10 GeneID 947848 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947848 HOGENOM HOG000294662 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000294662&db=HOGENOM6 InParanoid P26646 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P26646 IntAct P26646 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P26646* IntEnz 1.3.1.84 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.3.1.84 InterPro IPR002085 http://www.ebi.ac.uk/interpro/entry/IPR002085 InterPro IPR011032 http://www.ebi.ac.uk/interpro/entry/IPR011032 InterPro IPR013149 http://www.ebi.ac.uk/interpro/entry/IPR013149 InterPro IPR013154 http://www.ebi.ac.uk/interpro/entry/IPR013154 InterPro IPR014188 http://www.ebi.ac.uk/interpro/entry/IPR014188 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR020843 http://www.ebi.ac.uk/interpro/entry/IPR020843 KEGG_Gene ecj:JW3222 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3222 KEGG_Gene eco:b3253 http://www.genome.jp/dbget-bin/www_bget?eco:b3253 OMA AQMDYNS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AQMDYNS PANTHER PTHR11695 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11695 PANTHER PTHR11695:SF13 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11695:SF13 PDB 1O89 http://www.ebi.ac.uk/pdbe-srv/view/entry/1O89 PDB 1O8C http://www.ebi.ac.uk/pdbe-srv/view/entry/1O8C PDBsum 1O89 http://www.ebi.ac.uk/pdbsum/1O89 PDBsum 1O8C http://www.ebi.ac.uk/pdbsum/1O8C PSORT swissprot:ACUI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ACUI_ECOLI PSORT-B swissprot:ACUI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ACUI_ECOLI PSORT2 swissprot:ACUI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ACUI_ECOLI Pfam PF00107 http://pfam.xfam.org/family/PF00107 Pfam PF08240 http://pfam.xfam.org/family/PF08240 Phobius swissprot:ACUI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ACUI_ECOLI PhylomeDB P26646 http://phylomedb.org/?seqid=P26646 ProteinModelPortal P26646 http://www.proteinmodelportal.org/query/uniprot/P26646 PubMed 1370469 http://www.ncbi.nlm.nih.gov/pubmed/1370469 PubMed 15388933 http://www.ncbi.nlm.nih.gov/pubmed/15388933 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22563425 http://www.ncbi.nlm.nih.gov/pubmed/22563425 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417719 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417719 RefSeq WP_001148481 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001148481 SMART SM00829 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00829 SMR P26646 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P26646 STRING 511145.b3253 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3253&targetmode=cogs SUPFAM SSF50129 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50129 SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 SWISS-2DPAGE P26646 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P26646 TIGRFAMs TIGR02823 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02823 UniProtKB ACUI_ECOLI http://www.uniprot.org/uniprot/ACUI_ECOLI UniProtKB-AC P26646 http://www.uniprot.org/uniprot/P26646 charge swissprot:ACUI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ACUI_ECOLI eggNOG COG0604 http://eggnogapi.embl.de/nog_data/html/tree/COG0604 eggNOG ENOG4105D3Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D3Z epestfind swissprot:ACUI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ACUI_ECOLI garnier swissprot:ACUI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ACUI_ECOLI helixturnhelix swissprot:ACUI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ACUI_ECOLI hmoment swissprot:ACUI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ACUI_ECOLI iep swissprot:ACUI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ACUI_ECOLI inforesidue swissprot:ACUI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ACUI_ECOLI octanol swissprot:ACUI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ACUI_ECOLI pepcoil swissprot:ACUI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ACUI_ECOLI pepdigest swissprot:ACUI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ACUI_ECOLI pepinfo swissprot:ACUI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ACUI_ECOLI pepnet swissprot:ACUI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ACUI_ECOLI pepstats swissprot:ACUI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ACUI_ECOLI pepwheel swissprot:ACUI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ACUI_ECOLI pepwindow swissprot:ACUI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ACUI_ECOLI sigcleave swissprot:ACUI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ACUI_ECOLI ## Database ID URL or Descriptions # BioGrid 4260015 123 # DISRUPTION PHENOTYPE Simultaneous disruption of erfK, ybiS, ycfS and ynhG leads to loss of a significant proportion of muropeptides, including those with meso-DAP-3-meso-DAP-3 cross- links and with covalently anchored major outer membrane lipoprotein (Lpp) to the peptidoglycan. Overexpression of ycbB in this background increases meso-diaminopimelyl-3-a meso- diaminopimelyl-3 cross-links but does not restore Lpp anchoring. {ECO:0000269|PubMed 18456808}. # EcoGene EG11253 ycbB # FUNCTION YCBB_ECOLI Responsible, at least in part, for generating a meso- diaminopimelyl-3-a meso-diaminopimelyl-3 cross-link. {ECO 0000269|PubMed 18456808}. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0016755 transferase activity, transferring amino-acyl groups; IMP:EcoCyc. # GO_function GO:0016757 transferase activity, transferring glycosyl groups; IEA:UniProtKB-KW. # GO_function GO:0016807 cysteine-type carboxypeptidase activity; IMP:EcoCyc. # GO_function GO:0071972 peptidoglycan L,D-transpeptidase activity; IMP:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0008360 regulation of cell shape; IEA:UniProtKB-KW. # GO_process GO:0009252 peptidoglycan biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0043164 Gram-negative-bacterium-type cell wall biogenesis; IMP:EcoCyc. # GO_process GO:0044036 cell wall macromolecule metabolic process; IMP:EcoCyc. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 1.10.101.10 -; 2. # IntAct P22525 8 # InterPro IPR002477 Peptidoglycan-bd-like # InterPro IPR005490 LD_TPept_cat_dom # Organism YCBB_ECOLI Escherichia coli (strain K12) # PATHWAY YCBB_ECOLI Cell wall biogenesis; peptidoglycan biosynthesis. # PATRIC 32117063 VBIEscCol129921_0956 # PIR D64832 D64832 # PROSITE PS00092 N6_MTASE # Pfam PF01471 PG_binding_1 # Pfam PF03734 YkuD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCBB_ECOLI Probable L,D-transpeptidase YcbB # RefSeq NP_415445 NC_000913.3 # RefSeq WP_000925969 NZ_LN832404.1 # SIMILARITY Belongs to the YkuD family. {ECO 0000305}. # SUBCELLULAR LOCATION YCBB_ECOLI Membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. # SUPFAM SSF47090 SSF47090 # eggNOG COG2989 LUCA # eggNOG ENOG4105DIT Bacteria BLAST swissprot:YCBB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCBB_ECOLI BioCyc ECOL316407:JW0908-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0908-MONOMER BioCyc EcoCyc:EG11253-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11253-MONOMER BioCyc MetaCyc:EG11253-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11253-MONOMER DIP DIP-11474N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11474N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00025-08 http://dx.doi.org/10.1128/JB.00025-08 EC_number EC:2.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:2.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X57550 http://www.ebi.ac.uk/ena/data/view/X57550 ENZYME 2.-.-.- http://enzyme.expasy.org/EC/2.-.-.- EchoBASE EB1233 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1233 EcoGene EG11253 http://www.ecogene.org/geneInfo.php?eg_id=EG11253 EnsemblBacteria AAC74011 http://www.ensemblgenomes.org/id/AAC74011 EnsemblBacteria AAC74011 http://www.ensemblgenomes.org/id/AAC74011 EnsemblBacteria BAA35671 http://www.ensemblgenomes.org/id/BAA35671 EnsemblBacteria BAA35671 http://www.ensemblgenomes.org/id/BAA35671 EnsemblBacteria BAA35671 http://www.ensemblgenomes.org/id/BAA35671 EnsemblBacteria b0925 http://www.ensemblgenomes.org/id/b0925 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0016755 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016755 GO_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GO_function GO:0016807 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016807 GO_function GO:0071972 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071972 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0009252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009252 GO_process GO:0043164 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043164 GO_process GO:0044036 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044036 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 1.10.101.10 http://www.cathdb.info/version/latest/superfamily/1.10.101.10 GeneID 945541 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945541 HOGENOM HOG000118794 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118794&db=HOGENOM6 InParanoid P22525 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P22525 IntAct P22525 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P22525* IntEnz 2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2 InterPro IPR002477 http://www.ebi.ac.uk/interpro/entry/IPR002477 InterPro IPR005490 http://www.ebi.ac.uk/interpro/entry/IPR005490 KEGG_Gene ecj:JW0908 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0908 KEGG_Gene eco:b0925 http://www.genome.jp/dbget-bin/www_bget?eco:b0925 MINT MINT-1263904 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1263904 OMA HNLFQRD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HNLFQRD PROSITE PS00092 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00092 PSORT swissprot:YCBB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCBB_ECOLI PSORT-B swissprot:YCBB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCBB_ECOLI PSORT2 swissprot:YCBB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCBB_ECOLI Pfam PF01471 http://pfam.xfam.org/family/PF01471 Pfam PF03734 http://pfam.xfam.org/family/PF03734 Phobius swissprot:YCBB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCBB_ECOLI ProteinModelPortal P22525 http://www.proteinmodelportal.org/query/uniprot/P22525 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18456808 http://www.ncbi.nlm.nih.gov/pubmed/18456808 PubMed 1989883 http://www.ncbi.nlm.nih.gov/pubmed/1989883 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415445 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415445 RefSeq WP_000925969 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000925969 STRING 511145.b0925 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0925&targetmode=cogs SUPFAM SSF47090 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47090 UniProtKB YCBB_ECOLI http://www.uniprot.org/uniprot/YCBB_ECOLI UniProtKB-AC P22525 http://www.uniprot.org/uniprot/P22525 charge swissprot:YCBB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCBB_ECOLI eggNOG COG2989 http://eggnogapi.embl.de/nog_data/html/tree/COG2989 eggNOG ENOG4105DIT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DIT epestfind swissprot:YCBB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCBB_ECOLI garnier swissprot:YCBB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCBB_ECOLI helixturnhelix swissprot:YCBB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCBB_ECOLI hmoment swissprot:YCBB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCBB_ECOLI iep swissprot:YCBB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCBB_ECOLI inforesidue swissprot:YCBB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCBB_ECOLI octanol swissprot:YCBB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCBB_ECOLI pepcoil swissprot:YCBB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCBB_ECOLI pepdigest swissprot:YCBB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCBB_ECOLI pepinfo swissprot:YCBB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCBB_ECOLI pepnet swissprot:YCBB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCBB_ECOLI pepstats swissprot:YCBB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCBB_ECOLI pepwheel swissprot:YCBB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCBB_ECOLI pepwindow swissprot:YCBB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCBB_ECOLI sigcleave swissprot:YCBB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCBB_ECOLI ## Database ID URL or Descriptions # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # Organism YUAF_ECOLI Escherichia coli (strain K12) # RecName YUAF_ECOLI Uncharacterized membrane protein YuaF # RefSeq NP_061394 NC_002483.1 # RefSeq WP_000271587 NZ_CP014273.1 # SUBCELLULAR LOCATION YUAF_ECOLI Membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. BLAST swissprot:YUAF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YUAF_ECOLI EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GeneID 1263524 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263524 PSORT swissprot:YUAF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YUAF_ECOLI PSORT-B swissprot:YUAF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YUAF_ECOLI PSORT2 swissprot:YUAF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YUAF_ECOLI Phobius swissprot:YUAF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YUAF_ECOLI ProteinModelPortal Q9JMT4 http://www.proteinmodelportal.org/query/uniprot/Q9JMT4 RefSeq NP_061394 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061394 RefSeq WP_000271587 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000271587 UniProtKB YUAF_ECOLI http://www.uniprot.org/uniprot/YUAF_ECOLI UniProtKB-AC Q9JMT4 http://www.uniprot.org/uniprot/Q9JMT4 charge swissprot:YUAF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YUAF_ECOLI epestfind swissprot:YUAF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YUAF_ECOLI garnier swissprot:YUAF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YUAF_ECOLI helixturnhelix swissprot:YUAF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YUAF_ECOLI hmoment swissprot:YUAF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YUAF_ECOLI iep swissprot:YUAF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YUAF_ECOLI inforesidue swissprot:YUAF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YUAF_ECOLI octanol swissprot:YUAF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YUAF_ECOLI pepcoil swissprot:YUAF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YUAF_ECOLI pepdigest swissprot:YUAF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YUAF_ECOLI pepinfo swissprot:YUAF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YUAF_ECOLI pepnet swissprot:YUAF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YUAF_ECOLI pepstats swissprot:YUAF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YUAF_ECOLI pepwheel swissprot:YUAF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YUAF_ECOLI pepwindow swissprot:YUAF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YUAF_ECOLI sigcleave swissprot:YUAF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YUAF_ECOLI ## Database ID URL or Descriptions # EcoGene EG14467 sgrT # FUNCTION SGRT_ECOLI Acts to promote recovery from glucose-phosphate stress due to intracellular accumulation of glucose-6-phosphate caused by disruption of glycolytic flux or in the presence of (toxic) non- metabolizable glucose phosphate analogs. It may do so by inhibiting the transporter activity for glucose uptake (PtsG) as cells that overexpress this protein do not seem to import glucose although they have nearly wild-type levels of PtsG. {ECO 0000269|PubMed 18042713}. # GO_function GO:0004857 enzyme inhibitor activity; IMP:EcoCyc. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW. # GO_process GO:0046325 negative regulation of glucose import; IMP:EcoCyc. # GOslim_function GO:0030234 enzyme regulator activity # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # INDUCTION SGRT_ECOLI By (toxic) non-metabolizable glucose phosphate analogs under the control of SgrR (at protein level). {ECO 0000269|PubMed 18042713, ECO 0000269|PubMed 19121005}. # InterPro IPR031767 SgrT # MISCELLANEOUS SGRT_ECOLI Entirely encoded within the transcript for the small RNA sgrS. # Organism SGRT_ECOLI Escherichia coli (strain K12) # PATRIC 32115241 VBIEscCol129921_0072 # Pfam PF15894 SgrT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SGRT_ECOLI Putative inhibitor of glucose uptake transporter SgrT # RefSeq WP_001248770 NZ_LN832404.1 # RefSeq YP_002791237 NC_000913.3 BLAST swissprot:SGRT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SGRT_ECOLI BioCyc EcoCyc:MONOMER0-2842 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2842 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0708102104 http://dx.doi.org/10.1073/pnas.0708102104 DOI 10.1111/j.1365-2958.2008.06495.x http://dx.doi.org/10.1111/j.1365-2958.2008.06495.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14467 http://www.ecogene.org/geneInfo.php?eg_id=EG14467 EnsemblBacteria ACO59989 http://www.ensemblgenomes.org/id/ACO59989 EnsemblBacteria ACO59989 http://www.ensemblgenomes.org/id/ACO59989 EnsemblBacteria b4662 http://www.ensemblgenomes.org/id/b4662 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004857 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GO_process GO:0046325 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046325 GOslim_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 7751624 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7751624 HOGENOM HOG000267812 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267812&db=HOGENOM6 InterPro IPR031767 http://www.ebi.ac.uk/interpro/entry/IPR031767 KEGG_Gene eco:b4662 http://www.genome.jp/dbget-bin/www_bget?eco:b4662 PSORT swissprot:SGRT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SGRT_ECOLI PSORT-B swissprot:SGRT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SGRT_ECOLI PSORT2 swissprot:SGRT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SGRT_ECOLI Pfam PF15894 http://pfam.xfam.org/family/PF15894 Phobius swissprot:SGRT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SGRT_ECOLI PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18042713 http://www.ncbi.nlm.nih.gov/pubmed/18042713 PubMed 19121005 http://www.ncbi.nlm.nih.gov/pubmed/19121005 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001248770 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001248770 RefSeq YP_002791237 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_002791237 STRING 511145.b4662 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4662&targetmode=cogs UniProtKB SGRT_ECOLI http://www.uniprot.org/uniprot/SGRT_ECOLI UniProtKB-AC C1P5Z7 http://www.uniprot.org/uniprot/C1P5Z7 charge swissprot:SGRT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SGRT_ECOLI epestfind swissprot:SGRT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SGRT_ECOLI garnier swissprot:SGRT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SGRT_ECOLI helixturnhelix swissprot:SGRT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SGRT_ECOLI hmoment swissprot:SGRT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SGRT_ECOLI iep swissprot:SGRT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SGRT_ECOLI inforesidue swissprot:SGRT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SGRT_ECOLI octanol swissprot:SGRT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SGRT_ECOLI pepcoil swissprot:SGRT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SGRT_ECOLI pepdigest swissprot:SGRT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SGRT_ECOLI pepinfo swissprot:SGRT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SGRT_ECOLI pepnet swissprot:SGRT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SGRT_ECOLI pepstats swissprot:SGRT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SGRT_ECOLI pepwheel swissprot:SGRT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SGRT_ECOLI pepwindow swissprot:SGRT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SGRT_ECOLI sigcleave swissprot:SGRT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SGRT_ECOLI ## Database ID URL or Descriptions # InterPro IPR009940 DUF1472 # Organism YUBH_ECOLI Escherichia coli (strain K12) # Pfam PF07339 DUF1472 # RecName YUBH_ECOLI Uncharacterized protein YubH # RefSeq NP_061435 NC_002483.1 # SEQUENCE CAUTION Sequence=BAA97926.1; Type=Frameshift; Positions=73; Evidence={ECO 0000305}; BLAST swissprot:YUBH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YUBH_ECOLI EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1263510 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263510 InterPro IPR009940 http://www.ebi.ac.uk/interpro/entry/IPR009940 OMA NGGKHHA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NGGKHHA PSORT swissprot:YUBH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YUBH_ECOLI PSORT-B swissprot:YUBH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YUBH_ECOLI PSORT2 swissprot:YUBH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YUBH_ECOLI Pfam PF07339 http://pfam.xfam.org/family/PF07339 Phobius swissprot:YUBH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YUBH_ECOLI ProteinModelPortal Q9JMR5 http://www.proteinmodelportal.org/query/uniprot/Q9JMR5 RefSeq NP_061435 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061435 UniProtKB YUBH_ECOLI http://www.uniprot.org/uniprot/YUBH_ECOLI UniProtKB-AC Q9JMR5 http://www.uniprot.org/uniprot/Q9JMR5 charge swissprot:YUBH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YUBH_ECOLI epestfind swissprot:YUBH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YUBH_ECOLI garnier swissprot:YUBH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YUBH_ECOLI helixturnhelix swissprot:YUBH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YUBH_ECOLI hmoment swissprot:YUBH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YUBH_ECOLI iep swissprot:YUBH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YUBH_ECOLI inforesidue swissprot:YUBH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YUBH_ECOLI octanol swissprot:YUBH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YUBH_ECOLI pepcoil swissprot:YUBH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YUBH_ECOLI pepdigest swissprot:YUBH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YUBH_ECOLI pepinfo swissprot:YUBH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YUBH_ECOLI pepnet swissprot:YUBH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YUBH_ECOLI pepstats swissprot:YUBH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YUBH_ECOLI pepwheel swissprot:YUBH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YUBH_ECOLI pepwindow swissprot:YUBH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YUBH_ECOLI sigcleave swissprot:YUBH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YUBH_ECOLI ## Database ID URL or Descriptions # AltName STFQ_ECOLI Side tail fiber protein homolog from lambdoid prophage Qin # BioGrid 4260773 15 # EcoGene EG13826 stfQ # GO_function GO:0005198 structural molecule activity; IEA:InterPro. # GOslim_function GO:0005198 structural molecule activity # Gene3D 3.90.1340.10 -; 1. # IntAct P77515 12 # InterPro IPR005003 Phage_lambda_Stf-r1 # InterPro IPR011083 Phage_tail_collar_dom # Organism STFQ_ECOLI Escherichia coli (strain K12) # PATRIC 32118394 VBIEscCol129921_1617 # PIR F64909 F64909 # Pfam PF03335 Phage_fiber; 5 # Pfam PF07484 Collar # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Prophage side tail fiber protein homolog StfQ {ECO 0000305} # RefSeq NP_416065 NC_000913.3 # RefSeq WP_001027733 NZ_LN832404.1 # SIMILARITY Belongs to the tail fiber family. {ECO 0000305}. # eggNOG ENOG410685N Bacteria # eggNOG ENOG410XVET LUCA BLAST swissprot:STFQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:STFQ_ECOLI BioCyc ECOL316407:JW1540-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1540-MONOMER BioCyc EcoCyc:G6821-MONOMER http://biocyc.org/getid?id=EcoCyc:G6821-MONOMER DIP DIP-10931N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10931N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3587 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3587 EcoGene EG13826 http://www.ecogene.org/geneInfo.php?eg_id=EG13826 EnsemblBacteria AAC74620 http://www.ensemblgenomes.org/id/AAC74620 EnsemblBacteria AAC74620 http://www.ensemblgenomes.org/id/AAC74620 EnsemblBacteria BAA15251 http://www.ensemblgenomes.org/id/BAA15251 EnsemblBacteria BAA15251 http://www.ensemblgenomes.org/id/BAA15251 EnsemblBacteria BAA15251 http://www.ensemblgenomes.org/id/BAA15251 EnsemblBacteria b1547 http://www.ensemblgenomes.org/id/b1547 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005198 GOslim_function GO:0005198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005198 Gene3D 3.90.1340.10 http://www.cathdb.info/version/latest/superfamily/3.90.1340.10 GeneID 946098 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946098 HOGENOM HOG000118659 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118659&db=HOGENOM6 IntAct P77515 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77515* InterPro IPR005003 http://www.ebi.ac.uk/interpro/entry/IPR005003 InterPro IPR011083 http://www.ebi.ac.uk/interpro/entry/IPR011083 KEGG_Gene ecj:JW1540 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1540 KEGG_Gene eco:b1547 http://www.genome.jp/dbget-bin/www_bget?eco:b1547 OMA DMGWTIK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DMGWTIK PSORT swissprot:STFQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:STFQ_ECOLI PSORT-B swissprot:STFQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:STFQ_ECOLI PSORT2 swissprot:STFQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:STFQ_ECOLI Pfam PF03335 http://pfam.xfam.org/family/PF03335 Pfam PF07484 http://pfam.xfam.org/family/PF07484 Phobius swissprot:STFQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:STFQ_ECOLI ProteinModelPortal P77515 http://www.proteinmodelportal.org/query/uniprot/P77515 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416065 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416065 RefSeq WP_001027733 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001027733 SMR P77515 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77515 STRING 511145.b1547 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1547&targetmode=cogs UniProtKB STFQ_ECOLI http://www.uniprot.org/uniprot/STFQ_ECOLI UniProtKB-AC P77515 http://www.uniprot.org/uniprot/P77515 charge swissprot:STFQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:STFQ_ECOLI eggNOG ENOG410685N http://eggnogapi.embl.de/nog_data/html/tree/ENOG410685N eggNOG ENOG410XVET http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XVET epestfind swissprot:STFQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:STFQ_ECOLI garnier swissprot:STFQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:STFQ_ECOLI helixturnhelix swissprot:STFQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:STFQ_ECOLI hmoment swissprot:STFQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:STFQ_ECOLI iep swissprot:STFQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:STFQ_ECOLI inforesidue swissprot:STFQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:STFQ_ECOLI octanol swissprot:STFQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:STFQ_ECOLI pepcoil swissprot:STFQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:STFQ_ECOLI pepdigest swissprot:STFQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:STFQ_ECOLI pepinfo swissprot:STFQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:STFQ_ECOLI pepnet swissprot:STFQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:STFQ_ECOLI pepstats swissprot:STFQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:STFQ_ECOLI pepwheel swissprot:STFQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:STFQ_ECOLI pepwindow swissprot:STFQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:STFQ_ECOLI sigcleave swissprot:STFQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:STFQ_ECOLI ## Database ID URL or Descriptions # AltName DUT_ECOLI dUTP pyrophosphatase # BRENDA 3.6.1.23 2026 # BioGrid 4263424 499 # CATALYTIC ACTIVITY DUT_ECOLI dUTP + H(2)O = dUMP + diphosphate. # CDD cd07557 trimeric_dUTPase # COFACTOR DUT_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 15208312}; # EcoGene EG10251 dut # FUNCTION DUT_ECOLI This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0000287 magnesium ion binding; IBA:GO_Central. # GO_function GO:0004170 dUTP diphosphatase activity; IDA:EcoCyc. # GO_process GO:0006226 dUMP biosynthetic process; IBA:GO_Central. # GO_process GO:0046081 dUTP catabolic process; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 2.70.40.10 -; 1. # HAMAP MF_00116 dUTPase_bact # IntAct P06968 11 # InterPro IPR008180 dUTPase/dCTP_deaminase # InterPro IPR008181 dUTPase_1 # InterPro IPR029054 dUTPase-like # InterPro IPR033704 dUTPase_trimeric # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko00240 Pyrimidine metabolism # Organism DUT_ECOLI Escherichia coli (strain K12) # PATHWAY Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route) step 2/2. # PATRIC 32122767 VBIEscCol129921_3760 # PDB 1DUD X-ray; 2.30 A; A=1-151 # PDB 1DUP X-ray; 1.90 A; A=1-151 # PDB 1EU5 X-ray; 1.45 A; A=1-151 # PDB 1EUW X-ray; 1.05 A; A=1-151 # PDB 1RN8 X-ray; 1.93 A; A=1-151 # PDB 1RNJ X-ray; 1.70 A; A=1-151 # PDB 1SEH X-ray; 1.47 A; A=1-151 # PDB 1SYL X-ray; 1.95 A; A=1-151 # PDB 2HR6 X-ray; 1.84 A; A=1-151 # PDB 2HRM X-ray; 1.70 A; A=1-151 # PIR A30388 WPECDU # Pfam PF00692 dUTPase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DUT_ECOLI Deoxyuridine 5'-triphosphate nucleotidohydrolase # RefSeq NP_418097 NC_000913.3 # SIMILARITY Belongs to the dUTPase family. {ECO 0000305}. # SUBUNIT Homotrimer. {ECO:0000269|PubMed 15208312}. # SUPFAM SSF51283 SSF51283 # TIGRFAMs TIGR00576 dut # UniPathway UPA00610 UER00666 # eggNOG COG0756 LUCA # eggNOG ENOG4108Z1K Bacteria BLAST swissprot:DUT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DUT_ECOLI BioCyc ECOL316407:JW3615-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3615-MONOMER BioCyc EcoCyc:DUTP-PYROP-MONOMER http://biocyc.org/getid?id=EcoCyc:DUTP-PYROP-MONOMER BioCyc MetaCyc:DUTP-PYROP-MONOMER http://biocyc.org/getid?id=MetaCyc:DUTP-PYROP-MONOMER COG COG0756 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0756 DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/355740a0 http://dx.doi.org/10.1038/355740a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb0696-532 http://dx.doi.org/10.1038/nsb0696-532 DOI 10.1074/jbc.M406135200 http://dx.doi.org/10.1074/jbc.M406135200 DOI 10.1107/S0907444901004255 http://dx.doi.org/10.1107/S0907444901004255 DOI 10.1107/S0907444997016223 http://dx.doi.org/10.1107/S0907444997016223 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DisProt DP00337 http://www.disprot.org/protein.php?id=DP00337 EC_number EC:3.6.1.23 http://www.genome.jp/dbget-bin/www_bget?EC:3.6.1.23 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V01578 http://www.ebi.ac.uk/ena/data/view/V01578 EMBL X01714 http://www.ebi.ac.uk/ena/data/view/X01714 ENZYME 3.6.1.23 http://enzyme.expasy.org/EC/3.6.1.23 EchoBASE EB0247 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0247 EcoGene EG10251 http://www.ecogene.org/geneInfo.php?eg_id=EG10251 EnsemblBacteria AAC76664 http://www.ensemblgenomes.org/id/AAC76664 EnsemblBacteria AAC76664 http://www.ensemblgenomes.org/id/AAC76664 EnsemblBacteria BAE77652 http://www.ensemblgenomes.org/id/BAE77652 EnsemblBacteria BAE77652 http://www.ensemblgenomes.org/id/BAE77652 EnsemblBacteria BAE77652 http://www.ensemblgenomes.org/id/BAE77652 EnsemblBacteria b3640 http://www.ensemblgenomes.org/id/b3640 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0004170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004170 GO_process GO:0006226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006226 GO_process GO:0046081 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046081 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 2.70.40.10 http://www.cathdb.info/version/latest/superfamily/2.70.40.10 GeneID 948607 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948607 HAMAP MF_00116 http://hamap.expasy.org/unirule/MF_00116 HOGENOM HOG000028968 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000028968&db=HOGENOM6 InParanoid P06968 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P06968 IntAct P06968 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P06968* IntEnz 3.6.1.23 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.1.23 InterPro IPR008180 http://www.ebi.ac.uk/interpro/entry/IPR008180 InterPro IPR008181 http://www.ebi.ac.uk/interpro/entry/IPR008181 InterPro IPR029054 http://www.ebi.ac.uk/interpro/entry/IPR029054 InterPro IPR033704 http://www.ebi.ac.uk/interpro/entry/IPR033704 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW3615 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3615 KEGG_Gene eco:b3640 http://www.genome.jp/dbget-bin/www_bget?eco:b3640 KEGG_Orthology KO:K01520 http://www.genome.jp/dbget-bin/www_bget?KO:K01520 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Reaction rn:R02100 http://www.genome.jp/dbget-bin/www_bget?rn:R02100 MINT MINT-1279301 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1279301 OMA MVSAWNR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MVSAWNR PDB 1DUD http://www.ebi.ac.uk/pdbe-srv/view/entry/1DUD PDB 1DUP http://www.ebi.ac.uk/pdbe-srv/view/entry/1DUP PDB 1EU5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1EU5 PDB 1EUW http://www.ebi.ac.uk/pdbe-srv/view/entry/1EUW PDB 1RN8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1RN8 PDB 1RNJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1RNJ PDB 1SEH http://www.ebi.ac.uk/pdbe-srv/view/entry/1SEH PDB 1SYL http://www.ebi.ac.uk/pdbe-srv/view/entry/1SYL PDB 2HR6 http://www.ebi.ac.uk/pdbe-srv/view/entry/2HR6 PDB 2HRM http://www.ebi.ac.uk/pdbe-srv/view/entry/2HRM PDBsum 1DUD http://www.ebi.ac.uk/pdbsum/1DUD PDBsum 1DUP http://www.ebi.ac.uk/pdbsum/1DUP PDBsum 1EU5 http://www.ebi.ac.uk/pdbsum/1EU5 PDBsum 1EUW http://www.ebi.ac.uk/pdbsum/1EUW PDBsum 1RN8 http://www.ebi.ac.uk/pdbsum/1RN8 PDBsum 1RNJ http://www.ebi.ac.uk/pdbsum/1RNJ PDBsum 1SEH http://www.ebi.ac.uk/pdbsum/1SEH PDBsum 1SYL http://www.ebi.ac.uk/pdbsum/1SYL PDBsum 2HR6 http://www.ebi.ac.uk/pdbsum/2HR6 PDBsum 2HRM http://www.ebi.ac.uk/pdbsum/2HRM PSORT swissprot:DUT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DUT_ECOLI PSORT-B swissprot:DUT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DUT_ECOLI PSORT2 swissprot:DUT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DUT_ECOLI Pfam PF00692 http://pfam.xfam.org/family/PF00692 Phobius swissprot:DUT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DUT_ECOLI PhylomeDB P06968 http://phylomedb.org/?seqid=P06968 ProteinModelPortal P06968 http://www.proteinmodelportal.org/query/uniprot/P06968 PubMed 11375495 http://www.ncbi.nlm.nih.gov/pubmed/11375495 PubMed 1311056 http://www.ncbi.nlm.nih.gov/pubmed/1311056 PubMed 15208312 http://www.ncbi.nlm.nih.gov/pubmed/15208312 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6139280 http://www.ncbi.nlm.nih.gov/pubmed/6139280 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 8646539 http://www.ncbi.nlm.nih.gov/pubmed/8646539 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9757088 http://www.ncbi.nlm.nih.gov/pubmed/9757088 RefSeq NP_418097 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418097 SMR P06968 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P06968 STRING 511145.b3640 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3640&targetmode=cogs STRING COG0756 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0756&targetmode=cogs SUPFAM SSF51283 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51283 SWISS-2DPAGE P06968 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P06968 TIGRFAMs TIGR00576 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00576 UniProtKB DUT_ECOLI http://www.uniprot.org/uniprot/DUT_ECOLI UniProtKB-AC P06968 http://www.uniprot.org/uniprot/P06968 charge swissprot:DUT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DUT_ECOLI eggNOG COG0756 http://eggnogapi.embl.de/nog_data/html/tree/COG0756 eggNOG ENOG4108Z1K http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Z1K epestfind swissprot:DUT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DUT_ECOLI garnier swissprot:DUT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DUT_ECOLI helixturnhelix swissprot:DUT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DUT_ECOLI hmoment swissprot:DUT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DUT_ECOLI iep swissprot:DUT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DUT_ECOLI inforesidue swissprot:DUT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DUT_ECOLI octanol swissprot:DUT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DUT_ECOLI pepcoil swissprot:DUT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DUT_ECOLI pepdigest swissprot:DUT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DUT_ECOLI pepinfo swissprot:DUT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DUT_ECOLI pepnet swissprot:DUT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DUT_ECOLI pepstats swissprot:DUT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DUT_ECOLI pepwheel swissprot:DUT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DUT_ECOLI pepwindow swissprot:DUT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DUT_ECOLI sigcleave swissprot:DUT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DUT_ECOLI ## Database ID URL or Descriptions # BioGrid 4261006 4 # EcoGene EG12568 yjiG # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR011642 Gate_dom # Organism YJIG_ECOLI Escherichia coli (strain K12) # PATRIC 32124260 VBIEscCol129921_4473 # PIR A55889 A55889 # Pfam PF07670 Gate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJIG_ECOLI Inner membrane protein YjiG # RefSeq NP_418749 NC_000913.3 # RefSeq WP_000211971 NZ_LN832404.1 # SIMILARITY Belongs to the SpmB family. {ECO 0000305}. # SUBCELLULAR LOCATION YJIG_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG COG0700 LUCA # eggNOG ENOG4108P2H Bacteria BLAST swissprot:YJIG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJIG_ECOLI BioCyc ECOL316407:JW4292-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4292-MONOMER BioCyc EcoCyc:G7926-MONOMER http://biocyc.org/getid?id=EcoCyc:G7926-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.270.8.4076 http://dx.doi.org/10.1074/jbc.270.8.4076 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL U15029 http://www.ebi.ac.uk/ena/data/view/U15029 EchoBASE EB2456 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2456 EcoGene EG12568 http://www.ecogene.org/geneInfo.php?eg_id=EG12568 EnsemblBacteria AAC77285 http://www.ensemblgenomes.org/id/AAC77285 EnsemblBacteria AAC77285 http://www.ensemblgenomes.org/id/AAC77285 EnsemblBacteria BAE78322 http://www.ensemblgenomes.org/id/BAE78322 EnsemblBacteria BAE78322 http://www.ensemblgenomes.org/id/BAE78322 EnsemblBacteria BAE78322 http://www.ensemblgenomes.org/id/BAE78322 EnsemblBacteria b4329 http://www.ensemblgenomes.org/id/b4329 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 948854 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948854 HOGENOM HOG000111645 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000111645&db=HOGENOM6 IntAct P0AEH8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEH8* InterPro IPR011642 http://www.ebi.ac.uk/interpro/entry/IPR011642 KEGG_Gene ecj:JW4292 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4292 KEGG_Gene eco:b4329 http://www.genome.jp/dbget-bin/www_bget?eco:b4329 OMA CVINALV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CVINALV PSORT swissprot:YJIG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJIG_ECOLI PSORT-B swissprot:YJIG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJIG_ECOLI PSORT2 swissprot:YJIG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJIG_ECOLI Pfam PF07670 http://pfam.xfam.org/family/PF07670 Phobius swissprot:YJIG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJIG_ECOLI ProteinModelPortal P0AEH8 http://www.proteinmodelportal.org/query/uniprot/P0AEH8 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 7876157 http://www.ncbi.nlm.nih.gov/pubmed/7876157 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418749 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418749 RefSeq WP_000211971 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000211971 SMR P0AEH8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEH8 STRING 511145.b4329 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4329&targetmode=cogs UniProtKB YJIG_ECOLI http://www.uniprot.org/uniprot/YJIG_ECOLI UniProtKB-AC P0AEH8 http://www.uniprot.org/uniprot/P0AEH8 charge swissprot:YJIG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJIG_ECOLI eggNOG COG0700 http://eggnogapi.embl.de/nog_data/html/tree/COG0700 eggNOG ENOG4108P2H http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108P2H epestfind swissprot:YJIG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJIG_ECOLI garnier swissprot:YJIG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJIG_ECOLI helixturnhelix swissprot:YJIG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJIG_ECOLI hmoment swissprot:YJIG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJIG_ECOLI iep swissprot:YJIG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJIG_ECOLI inforesidue swissprot:YJIG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJIG_ECOLI octanol swissprot:YJIG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJIG_ECOLI pepcoil swissprot:YJIG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJIG_ECOLI pepdigest swissprot:YJIG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJIG_ECOLI pepinfo swissprot:YJIG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJIG_ECOLI pepnet swissprot:YJIG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJIG_ECOLI pepstats swissprot:YJIG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJIG_ECOLI pepwheel swissprot:YJIG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJIG_ECOLI pepwindow swissprot:YJIG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJIG_ECOLI sigcleave swissprot:YJIG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJIG_ECOLI ## Database ID URL or Descriptions # AltName NADH dehydrogenase I subunit B {ECO:0000255|HAMAP-Rule MF_01356} # AltName NDH-1 subunit B {ECO:0000255|HAMAP-Rule MF_01356} # AltName NUOB_ECOLI NUO2 # BioGrid 4262975 12 # CATALYTIC ACTIVITY NADH + a quinone = NAD(+) + a quinol. {ECO:0000255|HAMAP-Rule MF_01356}. # COFACTOR NUOB_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000255|HAMAP-Rule MF_01356}; Note=Binds 1 [4Fe-4S] cluster. {ECO 0000255|HAMAP-Rule MF_01356}; # EcoGene EG12083 nuoB # FUNCTION NUOB_ECOLI NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. # GO_component GO:0005886 plasma membrane; IDA:EcoliWiki. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_component GO:0030964 NADH dehydrogenase complex; IDA:EcoliWiki. # GO_component GO:0045272 plasma membrane respiratory chain complex I; IDA:EcoCyc. # GO_function GO:0005506 iron ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008137 NADH dehydrogenase (ubiquinone) activity; IMP:EcoCyc. # GO_function GO:0048038 quinone binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IMP:EcoCyc. # GO_process GO:0009060 aerobic respiration; IMP:EcoCyc. # GO_process GO:0015990 electron transport coupled proton transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0055085 transmembrane transport # Gene3D 3.40.50.700 -; 1. # HAMAP MF_01356 NDH1_NuoB # InterPro IPR006137 NADH_UbQ_OxRdtase-like_20kDa # InterPro IPR006138 NADH_UQ_OxRdtase_20Kd_su # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00190 Oxidative phosphorylation # KEGG_Pathway ko00910 Nitrogen metabolism # Organism NUOB_ECOLI Escherichia coli (strain K12) # PATRIC 32119941 VBIEscCol129921_2380 # PIR E65000 E65000 # PROSITE PS01150 COMPLEX1_20K # Pfam PF01058 Oxidored_q6 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NADH-quinone oxidoreductase subunit B {ECO:0000255|HAMAP-Rule MF_01356} # RefSeq NP_416790 NC_000913.3 # RefSeq WP_000386733 NZ_CP014272.1 # RefSeq WP_046608242 NZ_LN832404.1 # SIMILARITY Belongs to the complex I 20 kDa subunit family. {ECO:0000255|HAMAP-Rule MF_01356}. # SUBCELLULAR LOCATION NUOB_ECOLI Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. # SUBUNIT NUOB_ECOLI NDH-1 is composed of 13 different subunits. Subunits NuoB, CD, E, F, and G constitute the peripheral sector of the complex. # TCDB 3.D.1.1 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family # TIGRFAMs TIGR01957 nuoB_fam # eggNOG COG0377 LUCA # eggNOG ENOG4105ES3 Bacteria BLAST swissprot:NUOB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NUOB_ECOLI BioCyc ECOL316407:JW5875-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5875-MONOMER BioCyc EcoCyc:NUOB-MONOMER http://biocyc.org/getid?id=EcoCyc:NUOB-MONOMER BioCyc MetaCyc:NUOB-MONOMER http://biocyc.org/getid?id=MetaCyc:NUOB-MONOMER COG COG0377 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0377 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1993.1488 http://dx.doi.org/10.1006/jmbi.1993.1488 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1432-1033.1995.tb20594.x http://dx.doi.org/10.1111/j.1432-1033.1995.tb20594.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.6.5.11 {ECO:0000255|HAMAP-Rule:MF_01356} http://www.genome.jp/dbget-bin/www_bget?EC:1.6.5.11 {ECO:0000255|HAMAP-Rule:MF_01356} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X68301 http://www.ebi.ac.uk/ena/data/view/X68301 ENZYME 1.6.5.11 {ECO:0000255|HAMAP-Rule:MF_01356} http://enzyme.expasy.org/EC/1.6.5.11 {ECO:0000255|HAMAP-Rule:MF_01356} EchoBASE EB2008 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2008 EcoGene EG12083 http://www.ecogene.org/geneInfo.php?eg_id=EG12083 EnsemblBacteria AAC75347 http://www.ensemblgenomes.org/id/AAC75347 EnsemblBacteria AAC75347 http://www.ensemblgenomes.org/id/AAC75347 EnsemblBacteria BAA16121 http://www.ensemblgenomes.org/id/BAA16121 EnsemblBacteria BAA16121 http://www.ensemblgenomes.org/id/BAA16121 EnsemblBacteria BAA16121 http://www.ensemblgenomes.org/id/BAA16121 EnsemblBacteria b2287 http://www.ensemblgenomes.org/id/b2287 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0030964 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030964 GO_component GO:0045272 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045272 GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0008137 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008137 GO_function GO:0048038 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048038 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0009060 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009060 GO_process GO:0015990 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015990 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 3.40.50.700 http://www.cathdb.info/version/latest/superfamily/3.40.50.700 GeneID 946738 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946738 HAMAP MF_01356 http://hamap.expasy.org/unirule/MF_01356 HOGENOM HOG000228249 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000228249&db=HOGENOM6 InParanoid P0AFC7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFC7 IntAct P0AFC7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFC7* IntEnz 1.6.5.11 {ECO:0000255|HAMAP-Rule:MF_01356} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.6.5.11 {ECO:0000255|HAMAP-Rule:MF_01356} InterPro IPR006137 http://www.ebi.ac.uk/interpro/entry/IPR006137 InterPro IPR006138 http://www.ebi.ac.uk/interpro/entry/IPR006138 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5875 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5875 KEGG_Gene eco:b2287 http://www.genome.jp/dbget-bin/www_bget?eco:b2287 KEGG_Orthology KO:K00331 http://www.genome.jp/dbget-bin/www_bget?KO:K00331 KEGG_Pathway ko00190 http://www.genome.jp/kegg-bin/show_pathway?ko00190 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Reaction rn:R02166 http://www.genome.jp/dbget-bin/www_bget?rn:R02166 OMA PRPEAYI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PRPEAYI PROSITE PS01150 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01150 PSORT swissprot:NUOB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NUOB_ECOLI PSORT-B swissprot:NUOB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NUOB_ECOLI PSORT2 swissprot:NUOB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NUOB_ECOLI Pfam PF01058 http://pfam.xfam.org/family/PF01058 Phobius swissprot:NUOB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NUOB_ECOLI PhylomeDB P0AFC7 http://phylomedb.org/?seqid=P0AFC7 ProteinModelPortal P0AFC7 http://www.proteinmodelportal.org/query/uniprot/P0AFC7 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7607227 http://www.ncbi.nlm.nih.gov/pubmed/7607227 PubMed 7690854 http://www.ncbi.nlm.nih.gov/pubmed/7690854 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_416790 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416790 RefSeq WP_000386733 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000386733 RefSeq WP_046608242 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_046608242 SMR P0AFC7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFC7 STRING 511145.b2287 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2287&targetmode=cogs STRING COG0377 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0377&targetmode=cogs SWISS-2DPAGE P0AFC7 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AFC7 TCDB 3.D.1.1 http://www.tcdb.org/search/result.php?tc=3.D.1.1 TIGRFAMs TIGR01957 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01957 UniProtKB NUOB_ECOLI http://www.uniprot.org/uniprot/NUOB_ECOLI UniProtKB-AC P0AFC7 http://www.uniprot.org/uniprot/P0AFC7 charge swissprot:NUOB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NUOB_ECOLI eggNOG COG0377 http://eggnogapi.embl.de/nog_data/html/tree/COG0377 eggNOG ENOG4105ES3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ES3 epestfind swissprot:NUOB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NUOB_ECOLI garnier swissprot:NUOB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NUOB_ECOLI helixturnhelix swissprot:NUOB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NUOB_ECOLI hmoment swissprot:NUOB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NUOB_ECOLI iep swissprot:NUOB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NUOB_ECOLI inforesidue swissprot:NUOB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NUOB_ECOLI octanol swissprot:NUOB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NUOB_ECOLI pepcoil swissprot:NUOB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NUOB_ECOLI pepdigest swissprot:NUOB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NUOB_ECOLI pepinfo swissprot:NUOB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NUOB_ECOLI pepnet swissprot:NUOB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NUOB_ECOLI pepstats swissprot:NUOB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NUOB_ECOLI pepwheel swissprot:NUOB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NUOB_ECOLI pepwindow swissprot:NUOB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NUOB_ECOLI sigcleave swissprot:NUOB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NUOB_ECOLI ## Database ID URL or Descriptions # DISRUPTION PHENOTYPE None seen. An isbD overproducing strain cannot be made in the absence of the sibD gene. {ECO:0000269|PubMed 18710431}. # EcoGene EG14469 ibsD # FUNCTION IBSD_ECOLI May be a toxic protein; overexpression causes cessation of growth. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # INDUCTION The sibD sRNA probably represses expression of ibsD mRNA, either by destabilizing the transcript and/or preventing its translation (Probable). A type I toxin antitoxin (TA) system, where expression of the proteinaceous toxin is controlled by an antisense sRNA. {ECO 0000305}. # InterPro IPR025881 Toxin_Ibs # MISCELLANEOUS IBSD_ECOLI Part of the SIBd repeat region (formerly known as QUAD1d), encoded on the opposite strand from the sibD (formerly known as rygD) RNA. # Organism IBSD_ECOLI Escherichia coli (strain K12) # Pfam PF13956 Ibs_toxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName IBSD_ECOLI Small toxic protein IbsD # RefSeq YP_002791256 NC_000913.3 # SIMILARITY Belongs to the toxic protein ibs family. {ECO 0000305}. # SUBCELLULAR LOCATION IBSD_ECOLI Membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. BLAST swissprot:IBSD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:IBSD_ECOLI BioCyc EcoCyc:MONOMER0-2856 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2856 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2008.06394.x http://dx.doi.org/10.1111/j.1365-2958.2008.06394.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14469 http://www.ecogene.org/geneInfo.php?eg_id=EG14469 EnsemblBacteria ACO60008 http://www.ensemblgenomes.org/id/ACO60008 EnsemblBacteria ACO60008 http://www.ensemblgenomes.org/id/ACO60008 EnsemblBacteria b4664 http://www.ensemblgenomes.org/id/b4664 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GeneID 7751628 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7751628 InterPro IPR025881 http://www.ebi.ac.uk/interpro/entry/IPR025881 KEGG_Gene eco:b4664 http://www.genome.jp/dbget-bin/www_bget?eco:b4664 PSORT swissprot:IBSD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:IBSD_ECOLI PSORT-B swissprot:IBSD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:IBSD_ECOLI PSORT2 swissprot:IBSD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:IBSD_ECOLI Pfam PF13956 http://pfam.xfam.org/family/PF13956 Phobius swissprot:IBSD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:IBSD_ECOLI PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18710431 http://www.ncbi.nlm.nih.gov/pubmed/18710431 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq YP_002791256 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_002791256 UniProtKB IBSD_ECOLI http://www.uniprot.org/uniprot/IBSD_ECOLI UniProtKB-AC C1P616 http://www.uniprot.org/uniprot/C1P616 charge swissprot:IBSD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:IBSD_ECOLI epestfind swissprot:IBSD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:IBSD_ECOLI garnier swissprot:IBSD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:IBSD_ECOLI helixturnhelix swissprot:IBSD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:IBSD_ECOLI hmoment swissprot:IBSD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:IBSD_ECOLI iep swissprot:IBSD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:IBSD_ECOLI inforesidue swissprot:IBSD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:IBSD_ECOLI octanol swissprot:IBSD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:IBSD_ECOLI pepcoil swissprot:IBSD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:IBSD_ECOLI pepdigest swissprot:IBSD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:IBSD_ECOLI pepinfo swissprot:IBSD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:IBSD_ECOLI pepnet swissprot:IBSD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:IBSD_ECOLI pepstats swissprot:IBSD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:IBSD_ECOLI pepwheel swissprot:IBSD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:IBSD_ECOLI pepwindow swissprot:IBSD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:IBSD_ECOLI sigcleave swissprot:IBSD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:IBSD_ECOLI ## Database ID URL or Descriptions # BRENDA 3.1.13 2026 # DISRUPTION PHENOTYPE Essential. In depletion experiments the level of oligonucleotides is elevated and that of mononucleotides is severly reduced compared to wild-type. {ECO:0000269|PubMed 10200269}. # ENZYME REGULATION Inhibited by adenosine 3',5'-bisphosphate (PAP). {ECO:0000269|PubMed 16682444}. # EcoGene EG12480 orn # FUNCTION ORN_ECOLI 3'-to-5' exoribonuclease specific for small oligoribonucleotides 2 to 5 nucleotides in length, as well as small (2 to 5 nucleotides) ssDNA oligomers. Probably responsible for the final step in mRNA degradation. {ECO 0000269|PubMed 16682444, ECO 0000269|PubMed 7608090, ECO 0000269|PubMed 9573169}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000175 3'-5'-exoribonuclease activity; IDA:EcoCyc. # GO_function GO:0003676 nucleic acid binding; IEA:InterPro. # GO_function GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity; IDA:EcoCyc. # GO_function GO:0034611 oligoribonucleotidase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006401 RNA catabolic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0004518 nuclease activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # Gene3D 3.30.420.10 -; 1. # HAMAP MF_00045 Oligoribonuclease # InterPro IPR012337 RNaseH-like_dom # InterPro IPR013520 Exonuclease_RNaseT/DNA_pol3 # InterPro IPR022894 Oligoribonuclease # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # KEGG_Pathway ko03008 Ribosome biogenesis in eukaryotes # Organism ORN_ECOLI Escherichia coli (strain K12) # PATRIC 32123897 VBIEscCol129921_4296 # PDB 1YTA X-ray; 2.20 A; A/B/C/D=2-181 # PDB 2IGI X-ray; 1.70 A; A/B=2-181 # PIR S56390 S56390 # Pfam PF00929 RNase_T # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ORN_ECOLI Oligoribonuclease # RefSeq NP_418586 NC_000913.3 # RefSeq WP_001295188 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97061.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the oligoribonuclease family. {ECO 0000305}. # SIMILARITY Contains 1 exonuclease domain. {ECO 0000305}. # SMART SM00479 EXOIII # SUBCELLULAR LOCATION ORN_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 15039570}. # SUPFAM SSF53098 SSF53098 # eggNOG COG1949 LUCA # eggNOG ENOG4108RBP Bacteria BLAST swissprot:ORN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ORN_ECOLI BioCyc ECOL316407:JW5740-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5740-MONOMER BioCyc EcoCyc:G7842-MONOMER http://biocyc.org/getid?id=EcoCyc:G7842-MONOMER BioCyc MetaCyc:G7842-MONOMER http://biocyc.org/getid?id=MetaCyc:G7842-MONOMER COG COG1949 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1949 DIP DIP-10412N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10412N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.96.8.4372 http://dx.doi.org/10.1073/pnas.96.8.4372 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1093/nar/gkl247 http://dx.doi.org/10.1093/nar/gkl247 DOI 10.1107/S0907444904002252 http://dx.doi.org/10.1107/S0907444904002252 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 3.1.-.- http://enzyme.expasy.org/EC/3.1.-.- EchoBASE EB2373 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2373 EcoGene EG12480 http://www.ecogene.org/geneInfo.php?eg_id=EG12480 EnsemblBacteria AAC77122 http://www.ensemblgenomes.org/id/AAC77122 EnsemblBacteria AAC77122 http://www.ensemblgenomes.org/id/AAC77122 EnsemblBacteria BAE78166 http://www.ensemblgenomes.org/id/BAE78166 EnsemblBacteria BAE78166 http://www.ensemblgenomes.org/id/BAE78166 EnsemblBacteria BAE78166 http://www.ensemblgenomes.org/id/BAE78166 EnsemblBacteria b4162 http://www.ensemblgenomes.org/id/b4162 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000175 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000175 GO_function GO:0003676 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003676 GO_function GO:0008310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008310 GO_function GO:0034611 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034611 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006401 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 Gene3D 3.30.420.10 http://www.cathdb.info/version/latest/superfamily/3.30.420.10 GeneID 948675 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948675 HAMAP MF_00045 http://hamap.expasy.org/unirule/MF_00045 HOGENOM HOG000246596 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000246596&db=HOGENOM6 InParanoid P0A784 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A784 IntEnz 3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1 InterPro IPR012337 http://www.ebi.ac.uk/interpro/entry/IPR012337 InterPro IPR013520 http://www.ebi.ac.uk/interpro/entry/IPR013520 InterPro IPR022894 http://www.ebi.ac.uk/interpro/entry/IPR022894 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW5740 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5740 KEGG_Gene eco:b4162 http://www.genome.jp/dbget-bin/www_bget?eco:b4162 KEGG_Orthology KO:K13288 http://www.genome.jp/dbget-bin/www_bget?KO:K13288 KEGG_Pathway ko03008 http://www.genome.jp/kegg-bin/show_pathway?ko03008 OMA AFFHYRN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AFFHYRN PDB 1YTA http://www.ebi.ac.uk/pdbe-srv/view/entry/1YTA PDB 2IGI http://www.ebi.ac.uk/pdbe-srv/view/entry/2IGI PDBsum 1YTA http://www.ebi.ac.uk/pdbsum/1YTA PDBsum 2IGI http://www.ebi.ac.uk/pdbsum/2IGI PSORT swissprot:ORN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ORN_ECOLI PSORT-B swissprot:ORN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ORN_ECOLI PSORT2 swissprot:ORN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ORN_ECOLI Pfam PF00929 http://pfam.xfam.org/family/PF00929 Phobius swissprot:ORN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ORN_ECOLI PhylomeDB P0A784 http://phylomedb.org/?seqid=P0A784 ProteinModelPortal P0A784 http://www.proteinmodelportal.org/query/uniprot/P0A784 PubMed 10200269 http://www.ncbi.nlm.nih.gov/pubmed/10200269 PubMed 15039570 http://www.ncbi.nlm.nih.gov/pubmed/15039570 PubMed 16682444 http://www.ncbi.nlm.nih.gov/pubmed/16682444 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7608090 http://www.ncbi.nlm.nih.gov/pubmed/7608090 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9573169 http://www.ncbi.nlm.nih.gov/pubmed/9573169 RefSeq NP_418586 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418586 RefSeq WP_001295188 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295188 SMART SM00479 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00479 SMR P0A784 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A784 STRING 511145.b4162 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4162&targetmode=cogs STRING COG1949 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1949&targetmode=cogs SUPFAM SSF53098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098 UniProtKB ORN_ECOLI http://www.uniprot.org/uniprot/ORN_ECOLI UniProtKB-AC P0A784 http://www.uniprot.org/uniprot/P0A784 charge swissprot:ORN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ORN_ECOLI eggNOG COG1949 http://eggnogapi.embl.de/nog_data/html/tree/COG1949 eggNOG ENOG4108RBP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108RBP epestfind swissprot:ORN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ORN_ECOLI garnier swissprot:ORN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ORN_ECOLI helixturnhelix swissprot:ORN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ORN_ECOLI hmoment swissprot:ORN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ORN_ECOLI iep swissprot:ORN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ORN_ECOLI inforesidue swissprot:ORN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ORN_ECOLI octanol swissprot:ORN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ORN_ECOLI pepcoil swissprot:ORN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ORN_ECOLI pepdigest swissprot:ORN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ORN_ECOLI pepinfo swissprot:ORN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ORN_ECOLI pepnet swissprot:ORN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ORN_ECOLI pepstats swissprot:ORN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ORN_ECOLI pepwheel swissprot:ORN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ORN_ECOLI pepwindow swissprot:ORN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ORN_ECOLI sigcleave swissprot:ORN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ORN_ECOLI ## Database ID URL or Descriptions # BioGrid 4263069 6 # EcoGene EG14262 yciW # Gene3D 1.20.1290.10 -; 2. # IntAct P76035 2 # InterPro IPR029032 AhpD-like # Organism YCIW_ECOLI Escherichia coli (strain K12) # PATRIC 32117842 VBIEscCol129921_1341 # PIR B64877 B64877 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCIW_ECOLI Uncharacterized protein YciW # RefSeq NP_415803 NC_000913.3 # RefSeq WP_001335988 NZ_LN832404.1 # SUPFAM SSF69118 SSF69118; 2 # eggNOG COG2128 LUCA # eggNOG COG4950 LUCA # eggNOG ENOG4105Q4T Bacteria BLAST swissprot:YCIW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCIW_ECOLI BioCyc ECOL316407:JW5200-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5200-MONOMER BioCyc EcoCyc:G6640-MONOMER http://biocyc.org/getid?id=EcoCyc:G6640-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4010 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4010 EcoGene EG14262 http://www.ecogene.org/geneInfo.php?eg_id=EG14262 EnsemblBacteria AAC74369 http://www.ensemblgenomes.org/id/AAC74369 EnsemblBacteria AAC74369 http://www.ensemblgenomes.org/id/AAC74369 EnsemblBacteria BAE76396 http://www.ensemblgenomes.org/id/BAE76396 EnsemblBacteria BAE76396 http://www.ensemblgenomes.org/id/BAE76396 EnsemblBacteria BAE76396 http://www.ensemblgenomes.org/id/BAE76396 EnsemblBacteria b1287 http://www.ensemblgenomes.org/id/b1287 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 1.20.1290.10 http://www.cathdb.info/version/latest/superfamily/1.20.1290.10 GeneID 945859 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945859 HOGENOM HOG000120097 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120097&db=HOGENOM6 IntAct P76035 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76035* InterPro IPR029032 http://www.ebi.ac.uk/interpro/entry/IPR029032 KEGG_Gene ecj:JW5200 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5200 KEGG_Gene eco:b1287 http://www.genome.jp/dbget-bin/www_bget?eco:b1287 OMA CQLANTH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CQLANTH PSORT swissprot:YCIW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCIW_ECOLI PSORT-B swissprot:YCIW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCIW_ECOLI PSORT2 swissprot:YCIW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCIW_ECOLI Phobius swissprot:YCIW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCIW_ECOLI ProteinModelPortal P76035 http://www.proteinmodelportal.org/query/uniprot/P76035 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415803 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415803 RefSeq WP_001335988 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001335988 SMR P76035 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76035 STRING 511145.b1287 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1287&targetmode=cogs SUPFAM SSF69118 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF69118 UniProtKB YCIW_ECOLI http://www.uniprot.org/uniprot/YCIW_ECOLI UniProtKB-AC P76035 http://www.uniprot.org/uniprot/P76035 charge swissprot:YCIW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCIW_ECOLI eggNOG COG2128 http://eggnogapi.embl.de/nog_data/html/tree/COG2128 eggNOG COG4950 http://eggnogapi.embl.de/nog_data/html/tree/COG4950 eggNOG ENOG4105Q4T http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105Q4T epestfind swissprot:YCIW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCIW_ECOLI garnier swissprot:YCIW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCIW_ECOLI helixturnhelix swissprot:YCIW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCIW_ECOLI hmoment swissprot:YCIW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCIW_ECOLI iep swissprot:YCIW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCIW_ECOLI inforesidue swissprot:YCIW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCIW_ECOLI octanol swissprot:YCIW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCIW_ECOLI pepcoil swissprot:YCIW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCIW_ECOLI pepdigest swissprot:YCIW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCIW_ECOLI pepinfo swissprot:YCIW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCIW_ECOLI pepnet swissprot:YCIW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCIW_ECOLI pepstats swissprot:YCIW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCIW_ECOLI pepwheel swissprot:YCIW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCIW_ECOLI pepwindow swissprot:YCIW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCIW_ECOLI sigcleave swissprot:YCIW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCIW_ECOLI ## Database ID URL or Descriptions # AltName 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase {ECO:0000255|HAMAP-Rule MF_01813} # AltName Demethylmenaquinone methyltransferase {ECO:0000255|HAMAP-Rule MF_01813} # BRENDA 2.1.1.163 2026 # BioGrid 4261082 513 # CATALYTIC ACTIVITY UBIE_ECOLI A demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + S-adenosyl-L-homocysteine. {ECO 0000255|HAMAP- Rule MF_01813, ECO 0000269|PubMed 9045837}. # CATALYTIC ACTIVITY UBIE_ECOLI S-adenosyl-L-methionine + 2-methoxy-6-all- trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6- methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol. {ECO 0000255|HAMAP-Rule MF_01813, ECO 0000269|PubMed 9045837}. # EcoGene EG11473 ubiE # FUNCTION UBIE_ECOLI Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2). {ECO 0000255|HAMAP-Rule MF_01813, ECO 0000269|PubMed 9045837}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0008757 S-adenosylmethionine-dependent methyltransferase activity; ISS:EcoCyc. # GO_function GO:0043333 2-octaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity; IMP:EcoCyc. # GO_function GO:0102005 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity; IEA:UniProtKB-EC. # GO_process GO:0006744 ubiquinone biosynthetic process; IMP:EcoCyc. # GO_process GO:0009060 aerobic respiration; IEA:UniProtKB-HAMAP. # GO_process GO:0009234 menaquinone biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.150 -; 1. # HAMAP MF_01813 MenG_UbiE_methyltr # IntAct P0A887 6 # InterPro IPR004033 UbiE/COQ5_MeTrFase # InterPro IPR023576 UbiE/COQ5_MeTrFase_CS # InterPro IPR029063 SAM-dependent_MTases # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00130 Ubiquinone and other terpenoid-quinone biosynthesis # Organism UBIE_ECOLI Escherichia coli (strain K12) # PATHWAY UBIE_ECOLI Cofactor biosynthesis; ubiquinone biosynthesis. {ECO 0000255|HAMAP-Rule MF_01813, ECO 0000269|PubMed 9045837}. # PATHWAY UBIE_ECOLI Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate step 2/2. {ECO 0000255|HAMAP-Rule MF_01813, ECO 0000269|PubMed 9045837}. # PATRIC 32123167 VBIEscCol129921_3949 # PIR B65188 B65188 # PROSITE PS01183 UBIE_1 # PROSITE PS01184 UBIE_2 # PROSITE PS51608 SAM_MT_UBIE # Pfam PF01209 Ubie_methyltran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE {ECO:0000255|HAMAP-Rule MF_01813} # RefSeq WP_000227958 NZ_LN832404.1 # RefSeq YP_026269 NC_000913.3 # SIMILARITY Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family. {ECO:0000255|HAMAP-Rule MF_01813}. # SUPFAM SSF53335 SSF53335 # TIGRFAMs TIGR01934 MenG_MenH_UbiE # UniPathway UPA00079 UER00169 # eggNOG COG2226 LUCA # eggNOG ENOG4105DDZ Bacteria BLAST swissprot:UBIE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UBIE_ECOLI BioCyc ECOL316407:JW5581-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5581-MONOMER BioCyc EcoCyc:2-OCTAPRENYL-METHOXY-BENZOQ-METH-MONOMER http://biocyc.org/getid?id=EcoCyc:2-OCTAPRENYL-METHOXY-BENZOQ-METH-MONOMER BioCyc MetaCyc:2-OCTAPRENYL-METHOXY-BENZOQ-METH-MONOMER http://biocyc.org/getid?id=MetaCyc:2-OCTAPRENYL-METHOXY-BENZOQ-METH-MONOMER COG COG2226 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2226 DIP DIP-31831N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31831N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.1.163 {ECO:0000255|HAMAP-Rule:MF_01813, ECO:0000269|PubMed:9045837} http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.163 {ECO:0000255|HAMAP-Rule:MF_01813, ECO:0000269|PubMed:9045837} EC_number EC:2.1.1.201 {ECO:0000255|HAMAP-Rule:MF_01813, ECO:0000269|PubMed:9045837} http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.201 {ECO:0000255|HAMAP-Rule:MF_01813, ECO:0000269|PubMed:9045837} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.1.1.163 {ECO:0000255|HAMAP-Rule:MF_01813, ECO:0000269|PubMed:9045837} http://enzyme.expasy.org/EC/2.1.1.163 {ECO:0000255|HAMAP-Rule:MF_01813, ECO:0000269|PubMed:9045837} ENZYME 2.1.1.201 {ECO:0000255|HAMAP-Rule:MF_01813, ECO:0000269|PubMed:9045837} http://enzyme.expasy.org/EC/2.1.1.201 {ECO:0000255|HAMAP-Rule:MF_01813, ECO:0000269|PubMed:9045837} EchoBASE EB1441 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1441 EcoGene EG11473 http://www.ecogene.org/geneInfo.php?eg_id=EG11473 EnsemblBacteria AAT48227 http://www.ensemblgenomes.org/id/AAT48227 EnsemblBacteria AAT48227 http://www.ensemblgenomes.org/id/AAT48227 EnsemblBacteria BAE77468 http://www.ensemblgenomes.org/id/BAE77468 EnsemblBacteria BAE77468 http://www.ensemblgenomes.org/id/BAE77468 EnsemblBacteria BAE77468 http://www.ensemblgenomes.org/id/BAE77468 EnsemblBacteria b3833 http://www.ensemblgenomes.org/id/b3833 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0008757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008757 GO_function GO:0043333 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043333 GO_function GO:0102005 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0102005 GO_process GO:0006744 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006744 GO_process GO:0009060 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009060 GO_process GO:0009234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009234 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 GeneID 948926 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948926 HAMAP MF_01813 http://hamap.expasy.org/unirule/MF_01813 HOGENOM HOG000249463 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000249463&db=HOGENOM6 InParanoid P0A887 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A887 IntAct P0A887 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A887* IntEnz 2.1.1.163 {ECO:0000255|HAMAP-Rule:MF_01813, ECO:0000269|PubMed:9045837} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.163 {ECO:0000255|HAMAP-Rule:MF_01813, ECO:0000269|PubMed:9045837} IntEnz 2.1.1.201 {ECO:0000255|HAMAP-Rule:MF_01813, ECO:0000269|PubMed:9045837} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.201 {ECO:0000255|HAMAP-Rule:MF_01813, ECO:0000269|PubMed:9045837} InterPro IPR004033 http://www.ebi.ac.uk/interpro/entry/IPR004033 InterPro IPR023576 http://www.ebi.ac.uk/interpro/entry/IPR023576 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5581 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5581 KEGG_Gene eco:b3833 http://www.genome.jp/dbget-bin/www_bget?eco:b3833 KEGG_Orthology KO:K03183 http://www.genome.jp/dbget-bin/www_bget?KO:K03183 KEGG_Pathway ko00130 http://www.genome.jp/kegg-bin/show_pathway?ko00130 KEGG_Reaction rn:R04990 http://www.genome.jp/dbget-bin/www_bget?rn:R04990 KEGG_Reaction rn:R04993 http://www.genome.jp/dbget-bin/www_bget?rn:R04993 KEGG_Reaction rn:R06859 http://www.genome.jp/dbget-bin/www_bget?rn:R06859 KEGG_Reaction rn:R08774 http://www.genome.jp/dbget-bin/www_bget?rn:R08774 KEGG_Reaction rn:R09736 http://www.genome.jp/dbget-bin/www_bget?rn:R09736 MINT MINT-1243319 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1243319 OMA GGLHRAW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GGLHRAW PROSITE PS01183 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01183 PROSITE PS01184 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01184 PROSITE PS51608 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51608 PSORT swissprot:UBIE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UBIE_ECOLI PSORT-B swissprot:UBIE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UBIE_ECOLI PSORT2 swissprot:UBIE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UBIE_ECOLI Pfam PF01209 http://pfam.xfam.org/family/PF01209 Phobius swissprot:UBIE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UBIE_ECOLI PhylomeDB P0A887 http://phylomedb.org/?seqid=P0A887 ProteinModelPortal P0A887 http://www.proteinmodelportal.org/query/uniprot/P0A887 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9045837 http://www.ncbi.nlm.nih.gov/pubmed/9045837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000227958 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000227958 RefSeq YP_026269 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026269 SMR P0A887 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A887 STRING 511145.b3833 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3833&targetmode=cogs STRING COG2226 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2226&targetmode=cogs SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 TIGRFAMs TIGR01934 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01934 UniProtKB UBIE_ECOLI http://www.uniprot.org/uniprot/UBIE_ECOLI UniProtKB-AC P0A887 http://www.uniprot.org/uniprot/P0A887 charge swissprot:UBIE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UBIE_ECOLI eggNOG COG2226 http://eggnogapi.embl.de/nog_data/html/tree/COG2226 eggNOG ENOG4105DDZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DDZ epestfind swissprot:UBIE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UBIE_ECOLI garnier swissprot:UBIE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UBIE_ECOLI helixturnhelix swissprot:UBIE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UBIE_ECOLI hmoment swissprot:UBIE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UBIE_ECOLI iep swissprot:UBIE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UBIE_ECOLI inforesidue swissprot:UBIE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UBIE_ECOLI octanol swissprot:UBIE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UBIE_ECOLI pepcoil swissprot:UBIE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UBIE_ECOLI pepdigest swissprot:UBIE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UBIE_ECOLI pepinfo swissprot:UBIE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UBIE_ECOLI pepnet swissprot:UBIE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UBIE_ECOLI pepstats swissprot:UBIE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UBIE_ECOLI pepwheel swissprot:UBIE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UBIE_ECOLI pepwindow swissprot:UBIE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UBIE_ECOLI sigcleave swissprot:UBIE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UBIE_ECOLI ## Database ID URL or Descriptions # BioGrid 4262453 51 # EcoGene EG12837 yhdZ # FUNCTION YHDZ_ECOLI Probably part of a binding-protein-dependent transport system YdhWXYZ for an amino acid. Probably responsible for energy coupling to the transport system. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0015424 amino acid-transporting ATPase activity; IEA:InterPro. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.300 -; 1. # IntAct P45769 4 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # InterPro IPR030679 ABC_ATPase_HisP-typ # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00232 General L-amino acid transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism YHDZ_ECOLI Escherichia coli (strain K12) # PATRIC 32121974 VBIEscCol129921_3371 # PIR A65120 A65120 # PIRSF PIRSF039085 ABC_ATPase_HisP # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # Pfam PF00005 ABC_tran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHDZ_ECOLI Uncharacterized amino-acid ABC transporter ATP-binding protein YhdZ # RefSeq NP_417737 NC_000913.3 # RefSeq WP_000078349 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA # SUBCELLULAR LOCATION YHDZ_ECOLI Cell inner membrane {ECO 0000305}; Peripheral membrane protein {ECO 0000305}. # SUPFAM SSF52540 SSF52540 # TCDB 3.A.1.3.26 the atp-binding cassette (abc) superfamily # eggNOG COG1126 LUCA # eggNOG ENOG4105CDA Bacteria BLAST swissprot:YHDZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHDZ_ECOLI BioCyc ECOL316407:JW3239-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3239-MONOMER BioCyc EcoCyc:YHDZ-MONOMER http://biocyc.org/getid?id=EcoCyc:YHDZ-MONOMER COG COG1126 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1126 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2686 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2686 EcoGene EG12837 http://www.ecogene.org/geneInfo.php?eg_id=EG12837 EnsemblBacteria AAC76303 http://www.ensemblgenomes.org/id/AAC76303 EnsemblBacteria AAC76303 http://www.ensemblgenomes.org/id/AAC76303 EnsemblBacteria BAE77312 http://www.ensemblgenomes.org/id/BAE77312 EnsemblBacteria BAE77312 http://www.ensemblgenomes.org/id/BAE77312 EnsemblBacteria BAE77312 http://www.ensemblgenomes.org/id/BAE77312 EnsemblBacteria b3271 http://www.ensemblgenomes.org/id/b3271 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0015424 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015424 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947763 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947763 InParanoid P45769 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45769 IntAct P45769 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45769* InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR030679 http://www.ebi.ac.uk/interpro/entry/IPR030679 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3239 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3239 KEGG_Gene eco:b3271 http://www.genome.jp/dbget-bin/www_bget?eco:b3271 KEGG_Orthology KO:K09972 http://www.genome.jp/dbget-bin/www_bget?KO:K09972 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA EPMILLQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EPMILLQ PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:YHDZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHDZ_ECOLI PSORT-B swissprot:YHDZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHDZ_ECOLI PSORT2 swissprot:YHDZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHDZ_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Phobius swissprot:YHDZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHDZ_ECOLI PhylomeDB P45769 http://phylomedb.org/?seqid=P45769 ProteinModelPortal P45769 http://www.proteinmodelportal.org/query/uniprot/P45769 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417737 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417737 RefSeq WP_000078349 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000078349 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P45769 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45769 STRING 511145.b3271 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3271&targetmode=cogs STRING COG1126 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1126&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.3.26 http://www.tcdb.org/search/result.php?tc=3.A.1.3.26 UniProtKB YHDZ_ECOLI http://www.uniprot.org/uniprot/YHDZ_ECOLI UniProtKB-AC P45769 http://www.uniprot.org/uniprot/P45769 charge swissprot:YHDZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHDZ_ECOLI eggNOG COG1126 http://eggnogapi.embl.de/nog_data/html/tree/COG1126 eggNOG ENOG4105CDA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CDA epestfind swissprot:YHDZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHDZ_ECOLI garnier swissprot:YHDZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHDZ_ECOLI helixturnhelix swissprot:YHDZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHDZ_ECOLI hmoment swissprot:YHDZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHDZ_ECOLI iep swissprot:YHDZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHDZ_ECOLI inforesidue swissprot:YHDZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHDZ_ECOLI octanol swissprot:YHDZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHDZ_ECOLI pepcoil swissprot:YHDZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHDZ_ECOLI pepdigest swissprot:YHDZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHDZ_ECOLI pepinfo swissprot:YHDZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHDZ_ECOLI pepnet swissprot:YHDZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHDZ_ECOLI pepstats swissprot:YHDZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHDZ_ECOLI pepwheel swissprot:YHDZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHDZ_ECOLI pepwindow swissprot:YHDZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHDZ_ECOLI sigcleave swissprot:YHDZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHDZ_ECOLI ## Database ID URL or Descriptions # AltName SECG_ECOLI P12 # AltName SECG_ECOLI Preprotein translocase band 1 subunit # BioGrid 4259584 309 # EcoGene EG12095 secG # FUNCTION SECG_ECOLI Subunit of the protein translocation channel SecYEG. Overexpression of some hybrid proteins has been thought to jam the protein secretion apparatus resulting in cell death; while this may be true it also results in FtsH-mediated degradation of SecY. Treatment with antibiotics that block translation elongation such as chloramphenicol also leads to degradation of SecY and SecE but not SecG. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_component GO:0005886 plasma membrane; IDA:EcoliWiki. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity; IEA:InterPro. # GO_process GO:0006886 intracellular protein transport; IDA:EcoliWiki. # GO_process GO:0009306 protein secretion; IEA:InterPro. # GO_process GO:0043952 protein transport by the Sec complex; IDA:EcoCyc. # GO_process GO:0065002 intracellular protein transmembrane transport; IDA:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005622 intracellular # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0008565 protein transporter activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # INTERACTION SECG_ECOLI P10408 secA; NbExp=2; IntAct=EBI-6404248, EBI-543213; # IntAct P0AG99 2 # InterPro IPR004692 SecG # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02044 M00335 Sec (secretion) system # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko03060 Protein export # KEGG_Pathway ko03070 Bacterial secretion system # Organism SECG_ECOLI Escherichia coli (strain K12) # PATRIC 32121768 VBIEscCol129921_3268 # PDB 2AKH EM; 14.90 A; A/X=1-77 # PDB 2AKI EM; 14.90 A; A/X=1-77 # PDB 3J45 EM; 9.50 A; G=9-73 # PDB 3J46 EM; 10.10 A; G=9-73 # PIR S40402 S40402 # PRINTS PR01651 SECGEXPORT # PTM SECG_ECOLI The N-terminus is blocked. # Pfam PF03840 SecG # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SECG_ECOLI Protein-export membrane protein SecG # RefSeq NP_417642 NC_000913.3 # RefSeq WP_001295556 NZ_LN832404.1 # SIMILARITY Belongs to the SecG family. {ECO 0000305}. # SUBCELLULAR LOCATION SECG_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT SECG_ECOLI Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. SecG probably contacts ribosomal protein L23 and/or L29 when the translocation complex is docked with the ribosome. # TCDB 3.A.5.1 the general secretory pathway (sec) family # TIGRFAMs TIGR00810 secG # eggNOG COG1314 LUCA # eggNOG ENOG4105NTZ Bacteria BLAST swissprot:SECG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SECG_ECOLI BioCyc ECOL316407:JW3142-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3142-MONOMER BioCyc EcoCyc:SECG http://biocyc.org/getid?id=EcoCyc:SECG COG COG1314 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1314 DIP DIP-47480N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47480N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature04133 http://dx.doi.org/10.1038/nature04133 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.1172221 http://dx.doi.org/10.1126/science.1172221 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1146/annurev.biochem.77.061606.160747 http://dx.doi.org/10.1146/annurev.biochem.77.061606.160747 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D16463 http://www.ebi.ac.uk/ena/data/view/D16463 EMBL L12968 http://www.ebi.ac.uk/ena/data/view/L12968 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U01376 http://www.ebi.ac.uk/ena/data/view/U01376 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2019 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2019 EcoGene EG12095 http://www.ecogene.org/geneInfo.php?eg_id=EG12095 EnsemblBacteria AAC76207 http://www.ensemblgenomes.org/id/AAC76207 EnsemblBacteria AAC76207 http://www.ensemblgenomes.org/id/AAC76207 EnsemblBacteria BAE77219 http://www.ensemblgenomes.org/id/BAE77219 EnsemblBacteria BAE77219 http://www.ensemblgenomes.org/id/BAE77219 EnsemblBacteria BAE77219 http://www.ensemblgenomes.org/id/BAE77219 EnsemblBacteria b3175 http://www.ensemblgenomes.org/id/b3175 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015450 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015450 GO_process GO:0006886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006886 GO_process GO:0009306 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009306 GO_process GO:0043952 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043952 GO_process GO:0065002 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0065002 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 947720 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947720 HOGENOM HOG000071344 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000071344&db=HOGENOM6 InParanoid P0AG99 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AG99 IntAct P0AG99 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AG99* InterPro IPR004692 http://www.ebi.ac.uk/interpro/entry/IPR004692 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW3142 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3142 KEGG_Gene eco:b3175 http://www.genome.jp/dbget-bin/www_bget?eco:b3175 KEGG_Orthology KO:K03075 http://www.genome.jp/dbget-bin/www_bget?KO:K03075 KEGG_Pathway ko03060 http://www.genome.jp/kegg-bin/show_pathway?ko03060 KEGG_Pathway ko03070 http://www.genome.jp/kegg-bin/show_pathway?ko03070 MINT MINT-6477974 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-6477974 OMA WENLQQT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WENLQQT PDB 2AKH http://www.ebi.ac.uk/pdbe-srv/view/entry/2AKH PDB 2AKI http://www.ebi.ac.uk/pdbe-srv/view/entry/2AKI PDB 3J45 http://www.ebi.ac.uk/pdbe-srv/view/entry/3J45 PDB 3J46 http://www.ebi.ac.uk/pdbe-srv/view/entry/3J46 PDBsum 2AKH http://www.ebi.ac.uk/pdbsum/2AKH PDBsum 2AKI http://www.ebi.ac.uk/pdbsum/2AKI PDBsum 3J45 http://www.ebi.ac.uk/pdbsum/3J45 PDBsum 3J46 http://www.ebi.ac.uk/pdbsum/3J46 PRINTS PR01651 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01651 PSORT swissprot:SECG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SECG_ECOLI PSORT-B swissprot:SECG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SECG_ECOLI PSORT2 swissprot:SECG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SECG_ECOLI Pfam PF03840 http://pfam.xfam.org/family/PF03840 Phobius swissprot:SECG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SECG_ECOLI PhylomeDB P0AG99 http://phylomedb.org/?seqid=P0AG99 ProteinModelPortal P0AG99 http://www.proteinmodelportal.org/query/uniprot/P0AG99 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16292303 http://www.ncbi.nlm.nih.gov/pubmed/16292303 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18078384 http://www.ncbi.nlm.nih.gov/pubmed/18078384 PubMed 19661432 http://www.ncbi.nlm.nih.gov/pubmed/19661432 PubMed 7556084 http://www.ncbi.nlm.nih.gov/pubmed/7556084 PubMed 8034620 http://www.ncbi.nlm.nih.gov/pubmed/8034620 PubMed 8045257 http://www.ncbi.nlm.nih.gov/pubmed/8045257 PubMed 8244950 http://www.ncbi.nlm.nih.gov/pubmed/8244950 PubMed 8253068 http://www.ncbi.nlm.nih.gov/pubmed/8253068 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417642 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417642 RefSeq WP_001295556 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295556 SMR P0AG99 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AG99 STRING 511145.b3175 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3175&targetmode=cogs STRING COG1314 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1314&targetmode=cogs TCDB 3.A.5.1 http://www.tcdb.org/search/result.php?tc=3.A.5.1 TIGRFAMs TIGR00810 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00810 UniProtKB SECG_ECOLI http://www.uniprot.org/uniprot/SECG_ECOLI UniProtKB-AC P0AG99 http://www.uniprot.org/uniprot/P0AG99 charge swissprot:SECG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SECG_ECOLI eggNOG COG1314 http://eggnogapi.embl.de/nog_data/html/tree/COG1314 eggNOG ENOG4105NTZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105NTZ epestfind swissprot:SECG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SECG_ECOLI garnier swissprot:SECG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SECG_ECOLI helixturnhelix swissprot:SECG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SECG_ECOLI hmoment swissprot:SECG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SECG_ECOLI iep swissprot:SECG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SECG_ECOLI inforesidue swissprot:SECG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SECG_ECOLI octanol swissprot:SECG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SECG_ECOLI pepcoil swissprot:SECG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SECG_ECOLI pepdigest swissprot:SECG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SECG_ECOLI pepinfo swissprot:SECG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SECG_ECOLI pepnet swissprot:SECG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SECG_ECOLI pepstats swissprot:SECG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SECG_ECOLI pepwheel swissprot:SECG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SECG_ECOLI pepwindow swissprot:SECG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SECG_ECOLI sigcleave swissprot:SECG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SECG_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES KDSD_ECOLI Kinetic parameters KM=0.35 mM for Ru5P (at pH 8.5 and at 37 degrees Celsius) {ECO 0000269|PubMed 12805358}; KM=0.61 mM for A5P (at pH 8.5 and at 37 degrees Celsius) {ECO 0000269|PubMed 12805358}; pH dependence Optimum pH is 8.4. {ECO 0000269|PubMed 12805358}; # BRENDA 5.3.1.13 2026 # BioGrid 4259369 336 # CATALYTIC ACTIVITY KDSD_ECOLI D-arabinose 5-phosphate = D-ribulose 5- phosphate. # ENZYME REGULATION KDSD_ECOLI Completely inhibited by 10 uM of nickel, copper, cadmium and mercury ions. Inhibited by zinc with an IC(50) of 1-3 uM. Metal ion inhibition may be a mechanism to control activity in vivo. {ECO 0000269|PubMed 12805358, ECO 0000269|PubMed 20039350}. # EcoGene EG12803 kdsD # FUNCTION KDSD_ECOLI Involved in the biosynthesis of 3-deoxy-D-manno- octulosonate (KDO), a unique 8-carbon sugar component of lipopolysaccharides (LPSs). KdsD is not essential in the KDO biosynthesis and can be substituted by GutQ. Catalyzes the reversible aldol-ketol isomerization between D-ribulose 5- phosphate (Ru5P) and D-arabinose 5-phosphate (A5P). {ECO 0000269|PubMed 12805358, ECO 0000269|PubMed 16199563, ECO 0000269|PubMed 16765569}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0019146 arabinose-5-phosphate isomerase activity; IDA:EcoCyc. # GO_function GO:0030246 carbohydrate binding; IEA:InterPro. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0019294 keto-3-deoxy-D-manno-octulosonic acid biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # IntAct P45395 9 # InterPro IPR000644 CBS_dom # InterPro IPR001347 SIS # InterPro IPR004800 KdsD/KpsF-type # KEGG_Brite ko01000 Enzymes # Organism KDSD_ECOLI Escherichia coli (strain K12) # PATHWAY Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5- phosphate step 1/3. # PATHWAY KDSD_ECOLI Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. # PATRIC 32121814 VBIEscCol129921_3291 # PDB 2XHZ X-ray; 2.60 A; A/B/C/D=1-183 # PIR G65110 G65110 # PIRSF PIRSF004692 KdsD_KpsF # PROSITE PS51371 CBS; 2 # PROSITE PS51464 SIS # Pfam PF00571 CBS; 2 # Pfam PF01380 SIS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName KDSD_ECOLI Arabinose 5-phosphate isomerase KdsD # RefSeq NP_417664 NC_000913.3 # RefSeq WP_001295557 NZ_LN832404.1 # SIMILARITY Belongs to the SIS family. GutQ/KpsF subfamily. {ECO 0000305}. # SIMILARITY Contains 1 SIS domain. {ECO:0000255|PROSITE- ProRule PRU00797}. # SIMILARITY Contains 2 CBS domains. {ECO:0000255|PROSITE- ProRule PRU00703}. # SUBUNIT KDSD_ECOLI Homotetramer. {ECO 0000269|PubMed 12805358, ECO 0000269|PubMed 20954237}. # TIGRFAMs TIGR00393 kpsF # UniPathway UPA00357 UER00473 # eggNOG COG0517 LUCA # eggNOG COG0794 LUCA # eggNOG ENOG4105C2X Bacteria BLAST swissprot:KDSD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:KDSD_ECOLI BioCyc ECOL316407:JW3164-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3164-MONOMER BioCyc EcoCyc:G7662-MONOMER http://biocyc.org/getid?id=EcoCyc:G7662-MONOMER BioCyc MetaCyc:G7662-MONOMER http://biocyc.org/getid?id=MetaCyc:G7662-MONOMER COG COG0517 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0517 COG COG0794 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0794 DIP DIP-12910N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12910N DOI 10.1002/chem.200902619 http://dx.doi.org/10.1002/chem.200902619 DOI 10.1002/pro.525 http://dx.doi.org/10.1002/pro.525 DOI 10.1016/j.bbrc.2009.07.154 http://dx.doi.org/10.1016/j.bbrc.2009.07.154 DOI 10.1016/j.resmic.2005.11.014 http://dx.doi.org/10.1016/j.resmic.2005.11.014 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M303661200 http://dx.doi.org/10.1074/jbc.M303661200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.187.20.6936-6942.2005 http://dx.doi.org/10.1128/JB.187.20.6936-6942.2005 EC_number EC:5.3.1.13 http://www.genome.jp/dbget-bin/www_bget?EC:5.3.1.13 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 5.3.1.13 http://enzyme.expasy.org/EC/5.3.1.13 EchoBASE EB2655 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2655 EcoGene EG12803 http://www.ecogene.org/geneInfo.php?eg_id=EG12803 EnsemblBacteria AAC76229 http://www.ensemblgenomes.org/id/AAC76229 EnsemblBacteria AAC76229 http://www.ensemblgenomes.org/id/AAC76229 EnsemblBacteria BAE77241 http://www.ensemblgenomes.org/id/BAE77241 EnsemblBacteria BAE77241 http://www.ensemblgenomes.org/id/BAE77241 EnsemblBacteria BAE77241 http://www.ensemblgenomes.org/id/BAE77241 EnsemblBacteria b3197 http://www.ensemblgenomes.org/id/b3197 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0019146 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019146 GO_function GO:0030246 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030246 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0019294 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019294 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 947734 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947734 HOGENOM HOG000264729 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000264729&db=HOGENOM6 InParanoid P45395 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45395 IntAct P45395 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45395* IntEnz 5.3.1.13 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.3.1.13 InterPro IPR000644 http://www.ebi.ac.uk/interpro/entry/IPR000644 InterPro IPR001347 http://www.ebi.ac.uk/interpro/entry/IPR001347 InterPro IPR004800 http://www.ebi.ac.uk/interpro/entry/IPR004800 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3164 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3164 KEGG_Gene eco:b3197 http://www.genome.jp/dbget-bin/www_bget?eco:b3197 KEGG_Orthology KO:K06041 http://www.genome.jp/dbget-bin/www_bget?KO:K06041 OMA LMACLMR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LMACLMR PDB 2XHZ http://www.ebi.ac.uk/pdbe-srv/view/entry/2XHZ PDBsum 2XHZ http://www.ebi.ac.uk/pdbsum/2XHZ PROSITE PS51371 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51371 PROSITE PS51464 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51464 PSORT swissprot:KDSD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:KDSD_ECOLI PSORT-B swissprot:KDSD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:KDSD_ECOLI PSORT2 swissprot:KDSD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:KDSD_ECOLI Pfam PF00571 http://pfam.xfam.org/family/PF00571 Pfam PF01380 http://pfam.xfam.org/family/PF01380 Phobius swissprot:KDSD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:KDSD_ECOLI PhylomeDB P45395 http://phylomedb.org/?seqid=P45395 ProteinModelPortal P45395 http://www.proteinmodelportal.org/query/uniprot/P45395 PubMed 12805358 http://www.ncbi.nlm.nih.gov/pubmed/12805358 PubMed 16199563 http://www.ncbi.nlm.nih.gov/pubmed/16199563 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16765569 http://www.ncbi.nlm.nih.gov/pubmed/16765569 PubMed 19664604 http://www.ncbi.nlm.nih.gov/pubmed/19664604 PubMed 20039350 http://www.ncbi.nlm.nih.gov/pubmed/20039350 PubMed 20954237 http://www.ncbi.nlm.nih.gov/pubmed/20954237 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417664 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417664 RefSeq WP_001295557 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295557 SMR P45395 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45395 STRING 511145.b3197 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3197&targetmode=cogs STRING COG0517 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0517&targetmode=cogs STRING COG0794 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0794&targetmode=cogs TIGRFAMs TIGR00393 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00393 UniProtKB KDSD_ECOLI http://www.uniprot.org/uniprot/KDSD_ECOLI UniProtKB-AC P45395 http://www.uniprot.org/uniprot/P45395 charge swissprot:KDSD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:KDSD_ECOLI eggNOG COG0517 http://eggnogapi.embl.de/nog_data/html/tree/COG0517 eggNOG COG0794 http://eggnogapi.embl.de/nog_data/html/tree/COG0794 eggNOG ENOG4105C2X http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C2X epestfind swissprot:KDSD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:KDSD_ECOLI garnier swissprot:KDSD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:KDSD_ECOLI helixturnhelix swissprot:KDSD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:KDSD_ECOLI hmoment swissprot:KDSD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:KDSD_ECOLI iep swissprot:KDSD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:KDSD_ECOLI inforesidue swissprot:KDSD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:KDSD_ECOLI octanol swissprot:KDSD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:KDSD_ECOLI pepcoil swissprot:KDSD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:KDSD_ECOLI pepdigest swissprot:KDSD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:KDSD_ECOLI pepinfo swissprot:KDSD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:KDSD_ECOLI pepnet swissprot:KDSD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:KDSD_ECOLI pepstats swissprot:KDSD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:KDSD_ECOLI pepwheel swissprot:KDSD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:KDSD_ECOLI pepwindow swissprot:KDSD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:KDSD_ECOLI sigcleave swissprot:KDSD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:KDSD_ECOLI ## Database ID URL or Descriptions # AltName HSCB_ECOLI Hsc20 # BioGrid 4263037 42 # CDD cd06257 DnaJ # EcoGene EG12131 hscB # FUNCTION HSCB_ECOLI Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:1990230 iron-sulfur cluster transfer complex; IDA:EcoCyc. # GO_function GO:0051087 chaperone binding; IBA:GO_Central. # GO_process GO:0006457 protein folding; IEA:UniProtKB-HAMAP. # GO_process GO:0016226 iron-sulfur cluster assembly; IBA:GO_Central. # GO_process GO:0051259 protein oligomerization; IEA:InterPro. # GO_process GO:0097428 protein maturation by iron-sulfur cluster transfer; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006457 protein folding # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0051186 cofactor metabolic process # GOslim_process GO:0051604 protein maturation # Gene3D 1.10.287.110 -; 1. # Gene3D 1.20.1280.20 -; 1. # HAMAP MF_00682 HscB # IntAct P0A6L9 20 # InterPro IPR001623 DnaJ_domain # InterPro IPR004640 HscB # InterPro IPR009073 HscB_oligo_C # KEGG_Brite ko03110 Chaperones and folding catalysts # Organism HSCB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR14021 PTHR14021 # PATRIC 32120449 VBIEscCol129921_2627 # PDB 1FPO X-ray; 1.80 A; A/B/C=1-171 # PIR A36958 A36958 # PROSITE PS50076 DNAJ_2 # Pfam PF07743 HSCB_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HSCB_ECOLI Co-chaperone protein HscB # RefSeq NP_417022 NC_000913.3 # RefSeq WP_000384413 NZ_LN832404.1 # SIMILARITY Belongs to the HscB family. {ECO 0000305}. # SIMILARITY Contains 1 J domain. {ECO 0000305}. # SMART SM00271 DnaJ # SUBUNIT HSCB_ECOLI Interacts with HscA and stimulates its ATPase activity. Interacts with IscU. # SUPFAM SSF46565 SSF46565 # SUPFAM SSF47144 SSF47144 # TIGRFAMs TIGR00714 hscB # eggNOG COG1076 LUCA # eggNOG ENOG4108SWN Bacteria BLAST swissprot:HSCB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HSCB_ECOLI BioCyc ECOL316407:JW2511-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2511-MONOMER BioCyc EcoCyc:EG12131-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12131-MONOMER BioCyc MetaCyc:EG12131-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12131-MONOMER COG COG1076 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1076 DIP DIP-47847N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47847N DOI 10.1002/pro.5560060511 http://dx.doi.org/10.1002/pro.5560060511 DOI 10.1002/pro.5560060923 http://dx.doi.org/10.1002/pro.5560060923 DOI 10.1006/jmbi.2000.4252 http://dx.doi.org/10.1006/jmbi.2000.4252 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.130201997 http://dx.doi.org/10.1073/pnas.130201997 DOI 10.1073/pnas.91.6.2066 http://dx.doi.org/10.1073/pnas.91.6.2066 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U01827 http://www.ebi.ac.uk/ena/data/view/U01827 EMBL U05338 http://www.ebi.ac.uk/ena/data/view/U05338 EchoBASE EB2052 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2052 EcoGene EG12131 http://www.ecogene.org/geneInfo.php?eg_id=EG12131 EnsemblBacteria AAC75580 http://www.ensemblgenomes.org/id/AAC75580 EnsemblBacteria AAC75580 http://www.ensemblgenomes.org/id/AAC75580 EnsemblBacteria BAA16421 http://www.ensemblgenomes.org/id/BAA16421 EnsemblBacteria BAA16421 http://www.ensemblgenomes.org/id/BAA16421 EnsemblBacteria BAA16421 http://www.ensemblgenomes.org/id/BAA16421 EnsemblBacteria b2527 http://www.ensemblgenomes.org/id/b2527 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:1990230 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990230 GO_function GO:0051087 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051087 GO_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GO_process GO:0016226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016226 GO_process GO:0051259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051259 GO_process GO:0097428 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097428 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GOslim_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 Gene3D 1.10.287.110 http://www.cathdb.info/version/latest/superfamily/1.10.287.110 Gene3D 1.20.1280.20 http://www.cathdb.info/version/latest/superfamily/1.20.1280.20 GeneID 946995 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946995 HAMAP MF_00682 http://hamap.expasy.org/unirule/MF_00682 HOGENOM HOG000262077 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000262077&db=HOGENOM6 InParanoid P0A6L9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6L9 IntAct P0A6L9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6L9* InterPro IPR001623 http://www.ebi.ac.uk/interpro/entry/IPR001623 InterPro IPR004640 http://www.ebi.ac.uk/interpro/entry/IPR004640 InterPro IPR009073 http://www.ebi.ac.uk/interpro/entry/IPR009073 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW2511 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2511 KEGG_Gene eco:b2527 http://www.genome.jp/dbget-bin/www_bget?eco:b2527 KEGG_Orthology KO:K04082 http://www.genome.jp/dbget-bin/www_bget?KO:K04082 OMA QWARASQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QWARASQ PANTHER PTHR14021 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14021 PDB 1FPO http://www.ebi.ac.uk/pdbe-srv/view/entry/1FPO PDBsum 1FPO http://www.ebi.ac.uk/pdbsum/1FPO PROSITE PS50076 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50076 PSORT swissprot:HSCB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HSCB_ECOLI PSORT-B swissprot:HSCB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HSCB_ECOLI PSORT2 swissprot:HSCB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HSCB_ECOLI Pfam PF07743 http://pfam.xfam.org/family/PF07743 Phobius swissprot:HSCB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HSCB_ECOLI PhylomeDB P0A6L9 http://phylomedb.org/?seqid=P0A6L9 ProteinModelPortal P0A6L9 http://www.proteinmodelportal.org/query/uniprot/P0A6L9 PubMed 10869428 http://www.ncbi.nlm.nih.gov/pubmed/10869428 PubMed 11124030 http://www.ncbi.nlm.nih.gov/pubmed/11124030 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8134349 http://www.ncbi.nlm.nih.gov/pubmed/8134349 PubMed 8300516 http://www.ncbi.nlm.nih.gov/pubmed/8300516 PubMed 9144776 http://www.ncbi.nlm.nih.gov/pubmed/9144776 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9300502 http://www.ncbi.nlm.nih.gov/pubmed/9300502 RefSeq NP_417022 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417022 RefSeq WP_000384413 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000384413 SMART SM00271 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00271 SMR P0A6L9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6L9 STRING 511145.b2527 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2527&targetmode=cogs STRING COG1076 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1076&targetmode=cogs SUPFAM SSF46565 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46565 SUPFAM SSF47144 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47144 TIGRFAMs TIGR00714 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00714 UniProtKB HSCB_ECOLI http://www.uniprot.org/uniprot/HSCB_ECOLI UniProtKB-AC P0A6L9 http://www.uniprot.org/uniprot/P0A6L9 charge swissprot:HSCB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HSCB_ECOLI eggNOG COG1076 http://eggnogapi.embl.de/nog_data/html/tree/COG1076 eggNOG ENOG4108SWN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108SWN epestfind swissprot:HSCB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HSCB_ECOLI garnier swissprot:HSCB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HSCB_ECOLI helixturnhelix swissprot:HSCB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HSCB_ECOLI hmoment swissprot:HSCB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HSCB_ECOLI iep swissprot:HSCB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HSCB_ECOLI inforesidue swissprot:HSCB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HSCB_ECOLI octanol swissprot:HSCB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HSCB_ECOLI pepcoil swissprot:HSCB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HSCB_ECOLI pepdigest swissprot:HSCB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HSCB_ECOLI pepinfo swissprot:HSCB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HSCB_ECOLI pepnet swissprot:HSCB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HSCB_ECOLI pepstats swissprot:HSCB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HSCB_ECOLI pepwheel swissprot:HSCB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HSCB_ECOLI pepwindow swissprot:HSCB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HSCB_ECOLI sigcleave swissprot:HSCB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HSCB_ECOLI ## Database ID URL or Descriptions # AltName OMPT_ECOLI Omptin # AltName OMPT_ECOLI Outer membrane protein 3B # AltName OMPT_ECOLI Protease A # AltName OMPT_ECOLI Protease VII # BRENDA 3.4.23.49 2026 # BioGrid 4263520 151 # CATALYTIC ACTIVITY OMPT_ECOLI Has a virtual requirement for Arg in the P1 position and a slightly less stringent preference for this residue in the P1' position, which can also contain Lys, Gly or Val. # ENZYME REGULATION OMPT_ECOLI Inhibited by zinc. # EcoGene EG10673 ompT # FUNCTION OMPT_ECOLI Protease that can cleave T7 RNA polymerase, ferric enterobactin receptor protein (FEP), antimicrobial peptide protamine and other proteins. This protease has a specificity for paired basic residues. {ECO 0000269|PubMed 9683502}. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_component GO:0031230 intrinsic component of cell outer membrane; IDA:EcoliWiki. # GO_function GO:0004175 endopeptidase activity; IMP:EcoliWiki. # GO_function GO:0004190 aspartic-type endopeptidase activity; IEA:UniProtKB-KW. # GO_function GO:0004252 serine-type endopeptidase activity; IMP:EcoliWiki. # GO_process GO:0006508 proteolysis; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0008233 peptidase activity # GOslim_process GO:0008150 biological_process # Gene3D 2.40.128.90 -; 1. # InterPro IPR000036 Peptidase_A26_omptin # InterPro IPR020079 Peptidase_A26_CS # InterPro IPR020080 OM_adhesin/peptidase_omptin # InterPro IPR023619 Peptidase_A26 # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # MISCELLANEOUS OMPT_ECOLI Encoded by the cryptic lambdoid prophage DLP12. # MISCELLANEOUS OMPT_ECOLI Was originally classified as a serine protease, but it seems that OmpT could have a novel catalytic mechanism involving an Asp/His dyad and a pair of Asp. # Organism OMPT_ECOLI Escherichia coli (strain K12) # PATRIC 32116296 VBIEscCol129921_0588 # PDB 1I78 X-ray; 2.60 A; A/B=21-317 # PIR A31387 A31387 # PIRSF PIRSF001522 Peptidase_A26 # PRINTS PR00482 OMPTIN # PROSITE PS00834 OMPTIN_1 # PROSITE PS00835 OMPTIN_2 # Pfam PF01278 Omptin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName OMPT_ECOLI Protease 7 # RefSeq NP_415097 NC_000913.3 # RefSeq WP_001201845 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase A26 family. {ECO 0000305}. # SUBCELLULAR LOCATION OMPT_ECOLI Cell outer membrane; Multi-pass membrane protein. # SUBUNIT Homopentamer. {ECO 0000305}. # SUPFAM SSF69917 SSF69917 # TCDB 9.B.50.1 the outer membrane beta-barrel endoprotease, omptin (omptin) family # eggNOG COG4571 LUCA # eggNOG ENOG4108NC2 Bacteria BLAST swissprot:OMPT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:OMPT_ECOLI BioCyc ECOL316407:JW0554-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0554-MONOMER BioCyc EcoCyc:EG10673-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10673-MONOMER BioCyc MetaCyc:EG10673-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10673-MONOMER DOI 10.1002/elps.1150190539 http://dx.doi.org/10.1002/elps.1150190539 DOI 10.1016/S0014-5793(01)02863-0 http://dx.doi.org/10.1016/S0014-5793(01)02863-0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1432-1327.2000.01073.x http://dx.doi.org/10.1046/j.1432-1327.2000.01073.x DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/emboj/20.18.5033 http://dx.doi.org/10.1093/emboj/20.18.5033 DOI 10.1093/nar/16.3.1209 http://dx.doi.org/10.1093/nar/16.3.1209 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.23.49 http://www.genome.jp/dbget-bin/www_bget?EC:3.4.23.49 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M23630 http://www.ebi.ac.uk/ena/data/view/M23630 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EMBL X06903 http://www.ebi.ac.uk/ena/data/view/X06903 ENZYME 3.4.23.49 http://enzyme.expasy.org/EC/3.4.23.49 EchoBASE EB0667 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0667 EcoGene EG10673 http://www.ecogene.org/geneInfo.php?eg_id=EG10673 EnsemblBacteria AAC73666 http://www.ensemblgenomes.org/id/AAC73666 EnsemblBacteria AAC73666 http://www.ensemblgenomes.org/id/AAC73666 EnsemblBacteria BAA35199 http://www.ensemblgenomes.org/id/BAA35199 EnsemblBacteria BAA35199 http://www.ensemblgenomes.org/id/BAA35199 EnsemblBacteria BAA35199 http://www.ensemblgenomes.org/id/BAA35199 EnsemblBacteria b0565 http://www.ensemblgenomes.org/id/b0565 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0031230 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031230 GO_function GO:0004175 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004175 GO_function GO:0004190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004190 GO_function GO:0004252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004252 GO_process GO:0006508 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006508 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 2.40.128.90 http://www.cathdb.info/version/latest/superfamily/2.40.128.90 GeneID 945185 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945185 HOGENOM HOG000117799 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117799&db=HOGENOM6 IntEnz 3.4.23.49 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.23.49 InterPro IPR000036 http://www.ebi.ac.uk/interpro/entry/IPR000036 InterPro IPR020079 http://www.ebi.ac.uk/interpro/entry/IPR020079 InterPro IPR020080 http://www.ebi.ac.uk/interpro/entry/IPR020080 InterPro IPR023619 http://www.ebi.ac.uk/interpro/entry/IPR023619 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW0554 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0554 KEGG_Gene eco:b0565 http://www.genome.jp/dbget-bin/www_bget?eco:b0565 KEGG_Orthology KO:K01355 http://www.genome.jp/dbget-bin/www_bget?KO:K01355 OMA HYQTETI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HYQTETI PDB 1I78 http://www.ebi.ac.uk/pdbe-srv/view/entry/1I78 PDBsum 1I78 http://www.ebi.ac.uk/pdbsum/1I78 PRINTS PR00482 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00482 PROSITE PS00834 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00834 PROSITE PS00835 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00835 PSORT swissprot:OMPT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:OMPT_ECOLI PSORT-B swissprot:OMPT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:OMPT_ECOLI PSORT2 swissprot:OMPT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:OMPT_ECOLI Pfam PF01278 http://pfam.xfam.org/family/PF01278 Phobius swissprot:OMPT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:OMPT_ECOLI ProteinModelPortal P09169 http://www.proteinmodelportal.org/query/uniprot/P09169 PubMed 10651827 http://www.ncbi.nlm.nih.gov/pubmed/10651827 PubMed 11566868 http://www.ncbi.nlm.nih.gov/pubmed/11566868 PubMed 11576541 http://www.ncbi.nlm.nih.gov/pubmed/11576541 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3056908 http://www.ncbi.nlm.nih.gov/pubmed/3056908 PubMed 3278297 http://www.ncbi.nlm.nih.gov/pubmed/3278297 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9629924 http://www.ncbi.nlm.nih.gov/pubmed/9629924 PubMed 9683502 http://www.ncbi.nlm.nih.gov/pubmed/9683502 RefSeq NP_415097 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415097 RefSeq WP_001201845 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001201845 SMR P09169 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P09169 STRING 511145.b0565 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0565&targetmode=cogs SUPFAM SSF69917 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF69917 SWISS-2DPAGE P09169 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P09169 TCDB 9.B.50.1 http://www.tcdb.org/search/result.php?tc=9.B.50.1 UniProtKB OMPT_ECOLI http://www.uniprot.org/uniprot/OMPT_ECOLI UniProtKB-AC P09169 http://www.uniprot.org/uniprot/P09169 charge swissprot:OMPT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:OMPT_ECOLI eggNOG COG4571 http://eggnogapi.embl.de/nog_data/html/tree/COG4571 eggNOG ENOG4108NC2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108NC2 epestfind swissprot:OMPT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:OMPT_ECOLI garnier swissprot:OMPT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:OMPT_ECOLI helixturnhelix swissprot:OMPT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:OMPT_ECOLI hmoment swissprot:OMPT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:OMPT_ECOLI iep swissprot:OMPT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:OMPT_ECOLI inforesidue swissprot:OMPT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:OMPT_ECOLI octanol swissprot:OMPT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:OMPT_ECOLI pepcoil swissprot:OMPT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:OMPT_ECOLI pepdigest swissprot:OMPT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:OMPT_ECOLI pepinfo swissprot:OMPT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:OMPT_ECOLI pepnet swissprot:OMPT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:OMPT_ECOLI pepstats swissprot:OMPT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:OMPT_ECOLI pepwheel swissprot:OMPT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:OMPT_ECOLI pepwindow swissprot:OMPT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:OMPT_ECOLI sigcleave swissprot:OMPT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:OMPT_ECOLI ## Database ID URL or Descriptions # BioGrid 4259960 129 # EcoGene EG13315 ybhG # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # HAMAP MF_01304 UPF0194 # InterPro IPR022936 UPF0194_membrane_YbhG # InterPro IPR032317 HlyD_D23 # Organism YBHG_ECOLI Escherichia coli (strain K12) # PATRIC 32116791 VBIEscCol129921_0821 # PIR C64816 C64816 # Pfam PF16576 HlyD_D23 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBHG_ECOLI UPF0194 membrane protein YbhG # RefSeq NP_415316 NC_000913.3 # SIMILARITY Belongs to the UPF0194 family. {ECO 0000305}. # SUBCELLULAR LOCATION YBHG_ECOLI Periplasm {ECO 0000305}. # TCDB 3.A.1.105.15 the atp-binding cassette (abc) superfamily # eggNOG ENOG4105D0S Bacteria # eggNOG ENOG410XPU6 LUCA BLAST swissprot:YBHG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBHG_ECOLI BioCyc ECOL316407:JW0779-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0779-MONOMER BioCyc EcoCyc:G6412-MONOMER http://biocyc.org/getid?id=EcoCyc:G6412-MONOMER COG COG0845 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0845 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3099 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3099 EcoGene EG13315 http://www.ecogene.org/geneInfo.php?eg_id=EG13315 EnsemblBacteria AAC73882 http://www.ensemblgenomes.org/id/AAC73882 EnsemblBacteria AAC73882 http://www.ensemblgenomes.org/id/AAC73882 EnsemblBacteria BAA35455 http://www.ensemblgenomes.org/id/BAA35455 EnsemblBacteria BAA35455 http://www.ensemblgenomes.org/id/BAA35455 EnsemblBacteria BAA35455 http://www.ensemblgenomes.org/id/BAA35455 EnsemblBacteria b0795 http://www.ensemblgenomes.org/id/b0795 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 945414 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945414 HAMAP MF_01304 http://hamap.expasy.org/unirule/MF_01304 HOGENOM HOG000014875 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000014875&db=HOGENOM6 InParanoid P75777 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75777 IntAct P75777 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75777* InterPro IPR022936 http://www.ebi.ac.uk/interpro/entry/IPR022936 InterPro IPR032317 http://www.ebi.ac.uk/interpro/entry/IPR032317 KEGG_Gene ecj:JW0779 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0779 KEGG_Gene eco:b0795 http://www.genome.jp/dbget-bin/www_bget?eco:b0795 KEGG_Orthology KO:K01993 http://www.genome.jp/dbget-bin/www_bget?KO:K01993 OMA HEVQARQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HEVQARQ PSORT swissprot:YBHG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBHG_ECOLI PSORT-B swissprot:YBHG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBHG_ECOLI PSORT2 swissprot:YBHG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBHG_ECOLI Pfam PF16576 http://pfam.xfam.org/family/PF16576 Phobius swissprot:YBHG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBHG_ECOLI PhylomeDB P75777 http://phylomedb.org/?seqid=P75777 ProteinModelPortal P75777 http://www.proteinmodelportal.org/query/uniprot/P75777 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415316 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415316 SMR P75777 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75777 STRING 511145.b0795 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0795&targetmode=cogs STRING COG0845 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0845&targetmode=cogs TCDB 3.A.1.105.15 http://www.tcdb.org/search/result.php?tc=3.A.1.105.15 UniProtKB YBHG_ECOLI http://www.uniprot.org/uniprot/YBHG_ECOLI UniProtKB-AC P75777 http://www.uniprot.org/uniprot/P75777 charge swissprot:YBHG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBHG_ECOLI eggNOG ENOG4105D0S http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D0S eggNOG ENOG410XPU6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPU6 epestfind swissprot:YBHG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBHG_ECOLI garnier swissprot:YBHG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBHG_ECOLI helixturnhelix swissprot:YBHG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBHG_ECOLI hmoment swissprot:YBHG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBHG_ECOLI iep swissprot:YBHG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBHG_ECOLI inforesidue swissprot:YBHG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBHG_ECOLI octanol swissprot:YBHG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBHG_ECOLI pepcoil swissprot:YBHG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBHG_ECOLI pepdigest swissprot:YBHG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBHG_ECOLI pepinfo swissprot:YBHG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBHG_ECOLI pepnet swissprot:YBHG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBHG_ECOLI pepstats swissprot:YBHG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBHG_ECOLI pepwheel swissprot:YBHG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBHG_ECOLI pepwindow swissprot:YBHG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBHG_ECOLI sigcleave swissprot:YBHG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBHG_ECOLI ## Database ID URL or Descriptions # BioGrid 4259718 7 # EcoGene EG14400 ysaB # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GOslim_component GO:0005886 plasma membrane # InterPro IPR025728 YsaB-like # Organism YSAB_ECOLI Escherichia coli (strain K12) # PATRIC 32122596 VBIEscCol129921_3675 # Pfam PF13983 YsaB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YSAB_ECOLI Uncharacterized lipoprotein YsaB # RefSeq WP_000980107 NZ_LN832404.1 # RefSeq YP_588469 NC_000913.3 # SUBCELLULAR LOCATION YSAB_ECOLI Cell membrane {ECO 0000305}; Lipid-anchor {ECO 0000305}. # eggNOG ENOG4105RGS Bacteria # eggNOG ENOG4111X9P LUCA BLAST swissprot:YSAB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YSAB_ECOLI BioCyc ECOL316407:JW3532-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3532-MONOMER BioCyc EcoCyc:MONOMER0-2689 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2689 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14400 http://www.ecogene.org/geneInfo.php?eg_id=EG14400 EnsemblBacteria ABD18703 http://www.ensemblgenomes.org/id/ABD18703 EnsemblBacteria ABD18703 http://www.ensemblgenomes.org/id/ABD18703 EnsemblBacteria BAE77733 http://www.ensemblgenomes.org/id/BAE77733 EnsemblBacteria BAE77733 http://www.ensemblgenomes.org/id/BAE77733 EnsemblBacteria BAE77733 http://www.ensemblgenomes.org/id/BAE77733 EnsemblBacteria b4553 http://www.ensemblgenomes.org/id/b4553 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 1450292 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1450292 HOGENOM HOG000126025 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126025&db=HOGENOM6 IntAct Q2M7M3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q2M7M3* InterPro IPR025728 http://www.ebi.ac.uk/interpro/entry/IPR025728 KEGG_Gene ecj:JW3532 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3532 KEGG_Gene eco:b4553 http://www.genome.jp/dbget-bin/www_bget?eco:b4553 OMA NERFICS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NERFICS PSORT swissprot:YSAB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YSAB_ECOLI PSORT-B swissprot:YSAB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YSAB_ECOLI PSORT2 swissprot:YSAB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YSAB_ECOLI Pfam PF13983 http://pfam.xfam.org/family/PF13983 Phobius swissprot:YSAB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YSAB_ECOLI ProteinModelPortal Q2M7M3 http://www.proteinmodelportal.org/query/uniprot/Q2M7M3 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000980107 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000980107 RefSeq YP_588469 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_588469 SMR Q2M7M3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q2M7M3 STRING 511145.b4553 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4553&targetmode=cogs UniProtKB YSAB_ECOLI http://www.uniprot.org/uniprot/YSAB_ECOLI UniProtKB-AC Q2M7M3 http://www.uniprot.org/uniprot/Q2M7M3 charge swissprot:YSAB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YSAB_ECOLI eggNOG ENOG4105RGS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105RGS eggNOG ENOG4111X9P http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111X9P epestfind swissprot:YSAB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YSAB_ECOLI garnier swissprot:YSAB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YSAB_ECOLI helixturnhelix swissprot:YSAB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YSAB_ECOLI hmoment swissprot:YSAB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YSAB_ECOLI iep swissprot:YSAB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YSAB_ECOLI inforesidue swissprot:YSAB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YSAB_ECOLI octanol swissprot:YSAB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YSAB_ECOLI pepcoil swissprot:YSAB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YSAB_ECOLI pepdigest swissprot:YSAB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YSAB_ECOLI pepinfo swissprot:YSAB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YSAB_ECOLI pepnet swissprot:YSAB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YSAB_ECOLI pepstats swissprot:YSAB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YSAB_ECOLI pepwheel swissprot:YSAB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YSAB_ECOLI pepwindow swissprot:YSAB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YSAB_ECOLI sigcleave swissprot:YSAB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YSAB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260333 22 # EcoGene EG13505 leuE # FUNCTION LEUE_ECOLI Exporter of leucine. Can also transport its natural analog L-alpha-amino-n-butyric acid and some other structurally unrelated amino acids. {ECO 0000269|PubMed 16098526}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015190 L-leucine transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0015820 leucine transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # INDUCTION Induced by leucine, L-alpha-amino-n-butyric acid and, to a lesser extent, by several other amino acids. This induction is mediated by lrp. {ECO:0000269|PubMed 16098526}. # InterPro IPR001123 LysE-type # KEGG_Brite ko02000 Transporters # Organism LEUE_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30086 PTHR30086 # PATRIC 32118913 VBIEscCol129921_1874 # PIR F64940 F64940 # PIRSF PIRSF006324 LeuE # Pfam PF01810 LysE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LEUE_ECOLI Leucine efflux protein # RefSeq NP_416312 NC_000913.3 # RefSeq WP_000457206 NZ_LN832404.1 # SIMILARITY Belongs to the rht family. {ECO 0000305}. # SUBCELLULAR LOCATION LEUE_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # TCDB 2.A.76.1 the resistance to homoserine/threonine (rhtb) family # eggNOG COG1280 LUCA # eggNOG ENOG4108NIW Bacteria BLAST swissprot:LEUE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LEUE_ECOLI BioCyc ECOL316407:JW1787-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1787-MONOMER BioCyc EcoCyc:G6984-MONOMER http://biocyc.org/getid?id=EcoCyc:G6984-MONOMER BioCyc MetaCyc:G6984-MONOMER http://biocyc.org/getid?id=MetaCyc:G6984-MONOMER COG COG1280 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1280 DOI 10.1016/j.febslet.2005.07.031 http://dx.doi.org/10.1016/j.febslet.2005.07.031 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3278 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3278 EcoGene EG13505 http://www.ecogene.org/geneInfo.php?eg_id=EG13505 EnsemblBacteria AAC74868 http://www.ensemblgenomes.org/id/AAC74868 EnsemblBacteria AAC74868 http://www.ensemblgenomes.org/id/AAC74868 EnsemblBacteria BAA15593 http://www.ensemblgenomes.org/id/BAA15593 EnsemblBacteria BAA15593 http://www.ensemblgenomes.org/id/BAA15593 EnsemblBacteria BAA15593 http://www.ensemblgenomes.org/id/BAA15593 EnsemblBacteria b1798 http://www.ensemblgenomes.org/id/b1798 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015190 GO_process GO:0015820 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015820 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 946157 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946157 HOGENOM HOG000122945 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122945&db=HOGENOM6 InParanoid P76249 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76249 InterPro IPR001123 http://www.ebi.ac.uk/interpro/entry/IPR001123 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1787 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1787 KEGG_Gene eco:b1798 http://www.genome.jp/dbget-bin/www_bget?eco:b1798 KEGG_Orthology KO:K11250 http://www.genome.jp/dbget-bin/www_bget?KO:K11250 OMA VCAGMIG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VCAGMIG PANTHER PTHR30086 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30086 PSORT swissprot:LEUE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LEUE_ECOLI PSORT-B swissprot:LEUE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LEUE_ECOLI PSORT2 swissprot:LEUE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LEUE_ECOLI Pfam PF01810 http://pfam.xfam.org/family/PF01810 Phobius swissprot:LEUE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LEUE_ECOLI PhylomeDB P76249 http://phylomedb.org/?seqid=P76249 ProteinModelPortal P76249 http://www.proteinmodelportal.org/query/uniprot/P76249 PubMed 16098526 http://www.ncbi.nlm.nih.gov/pubmed/16098526 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416312 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416312 RefSeq WP_000457206 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000457206 STRING 511145.b1798 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1798&targetmode=cogs STRING COG1280 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1280&targetmode=cogs TCDB 2.A.76.1 http://www.tcdb.org/search/result.php?tc=2.A.76.1 UniProtKB LEUE_ECOLI http://www.uniprot.org/uniprot/LEUE_ECOLI UniProtKB-AC P76249 http://www.uniprot.org/uniprot/P76249 charge swissprot:LEUE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LEUE_ECOLI eggNOG COG1280 http://eggnogapi.embl.de/nog_data/html/tree/COG1280 eggNOG ENOG4108NIW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108NIW epestfind swissprot:LEUE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LEUE_ECOLI garnier swissprot:LEUE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LEUE_ECOLI helixturnhelix swissprot:LEUE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LEUE_ECOLI hmoment swissprot:LEUE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LEUE_ECOLI iep swissprot:LEUE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LEUE_ECOLI inforesidue swissprot:LEUE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LEUE_ECOLI octanol swissprot:LEUE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LEUE_ECOLI pepcoil swissprot:LEUE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LEUE_ECOLI pepdigest swissprot:LEUE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LEUE_ECOLI pepinfo swissprot:LEUE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LEUE_ECOLI pepnet swissprot:LEUE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LEUE_ECOLI pepstats swissprot:LEUE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LEUE_ECOLI pepwheel swissprot:LEUE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LEUE_ECOLI pepwindow swissprot:LEUE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LEUE_ECOLI sigcleave swissprot:LEUE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LEUE_ECOLI ## Database ID URL or Descriptions # BioGrid 4261770 4 # EcoGene EG11875 yiiR # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR008523 DUF805 # Organism YIIR_ECOLI Escherichia coli (strain K12) # PATRIC 32123355 VBIEscCol129921_4038 # PIR S40864 S40864 # Pfam PF05656 DUF805 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIIR_ECOLI Uncharacterized protein YiiR # RefSeq NP_418356 NC_000913.3 # RefSeq WP_000155257 NZ_LN832404.1 # eggNOG COG3152 LUCA # eggNOG ENOG4108VTS Bacteria BLAST swissprot:YIIR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIIR_ECOLI BioCyc ECOL316407:JW3892-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3892-MONOMER BioCyc EcoCyc:EG11875-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11875-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1821 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1821 EcoGene EG11875 http://www.ecogene.org/geneInfo.php?eg_id=EG11875 EnsemblBacteria AAC76903 http://www.ensemblgenomes.org/id/AAC76903 EnsemblBacteria AAC76903 http://www.ensemblgenomes.org/id/AAC76903 EnsemblBacteria BAE77389 http://www.ensemblgenomes.org/id/BAE77389 EnsemblBacteria BAE77389 http://www.ensemblgenomes.org/id/BAE77389 EnsemblBacteria BAE77389 http://www.ensemblgenomes.org/id/BAE77389 EnsemblBacteria b3921 http://www.ensemblgenomes.org/id/b3921 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 948417 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948417 HOGENOM HOG000253107 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000253107&db=HOGENOM6 IntAct P0AF34 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AF34* InterPro IPR008523 http://www.ebi.ac.uk/interpro/entry/IPR008523 KEGG_Gene ecj:JW3892 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3892 KEGG_Gene eco:b3921 http://www.genome.jp/dbget-bin/www_bget?eco:b3921 OMA RDFWIWM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RDFWIWM PSORT swissprot:YIIR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIIR_ECOLI PSORT-B swissprot:YIIR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIIR_ECOLI PSORT2 swissprot:YIIR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIIR_ECOLI Pfam PF05656 http://pfam.xfam.org/family/PF05656 Phobius swissprot:YIIR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIIR_ECOLI ProteinModelPortal P0AF34 http://www.proteinmodelportal.org/query/uniprot/P0AF34 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418356 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418356 RefSeq WP_000155257 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000155257 STRING 511145.b3921 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3921&targetmode=cogs UniProtKB YIIR_ECOLI http://www.uniprot.org/uniprot/YIIR_ECOLI UniProtKB-AC P0AF34 http://www.uniprot.org/uniprot/P0AF34 charge swissprot:YIIR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIIR_ECOLI eggNOG COG3152 http://eggnogapi.embl.de/nog_data/html/tree/COG3152 eggNOG ENOG4108VTS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108VTS epestfind swissprot:YIIR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIIR_ECOLI garnier swissprot:YIIR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIIR_ECOLI helixturnhelix swissprot:YIIR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIIR_ECOLI hmoment swissprot:YIIR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIIR_ECOLI iep swissprot:YIIR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIIR_ECOLI inforesidue swissprot:YIIR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIIR_ECOLI octanol swissprot:YIIR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIIR_ECOLI pepcoil swissprot:YIIR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIIR_ECOLI pepdigest swissprot:YIIR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIIR_ECOLI pepinfo swissprot:YIIR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIIR_ECOLI pepnet swissprot:YIIR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIIR_ECOLI pepstats swissprot:YIIR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIIR_ECOLI pepwheel swissprot:YIIR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIIR_ECOLI pepwindow swissprot:YIIR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIIR_ECOLI sigcleave swissprot:YIIR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIIR_ECOLI ## Database ID URL or Descriptions # AltName GTP molybdopterin guanylyltransferase # AltName MOBA_ECOLI Mo-MPT guanylyltransferase # AltName MOBA_ECOLI Molybdopterin guanylyltransferase # AltName MOBA_ECOLI Molybdopterin-guanine dinucleotide biosynthesis protein A # AltName MOBA_ECOLI Molybdopterin-guanine dinucleotide synthase # AltName MOBA_ECOLI Protein FA # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=6.5 uM for GTP {ECO 0000269|PubMed:21081498}; # BRENDA 2.7.7.77 2026 # CATALYTIC ACTIVITY MOBA_ECOLI GTP + molybdenum cofactor = diphosphate + guanylyl molybdenum cofactor. {ECO 0000269|PubMed 10978348, ECO 0000269|PubMed 21081498}. # CDD cd02503 MobA # COFACTOR MOBA_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 10978347, ECO 0000269|PubMed 10978348}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 10978347, ECO 0000269|PubMed 10978348}; Note=Both divalent cations appear to be equally efficient in an vitro reconstitution assay. {ECO 0000269|PubMed 10978347, ECO 0000269|PubMed 10978348}; # DISRUPTION PHENOTYPE Cells lacking this gene are chlorate- resistant, fail to synthesize MGD and accumulate elevated quantities of MPT. {ECO:0000269|PubMed 1648082}. # DOMAIN MOBA_ECOLI The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein. When the N-terminal domain of MobA is fused to the C-terminal domain of MocA, comparable kinetic constants as wild-type MobA are obtained with GTP, and the activity with CTP is completely lost. Consistent results are obtained when the N-terminal domain of MocA is fused to the C- terminal domain of MobA the kinetic constants with CTP are comparable with the ones found for wild-type MocA, although no activity with GTP is detected. {ECO 0000269|PubMed 21081498}. # EcoGene EG11829 mobA # FUNCTION MOBA_ECOLI Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor. Is also involved in the biosynthesis of the bis-MGD form of the Moco cofactor (Mo-bisMGD) in which the metal is symmetrically ligated by the dithiolene groups of two MGD molecules. Is necessary and sufficient for the in vitro activation of the DMSOR molybdoenzyme that uses the Mo-bisMGD form of molybdenum cofactor, which implies formation and efficient insertion of the cofactor into the enzyme without the need of a chaperone. Is specific for GTP since other nucleotides such as ATP and GMP cannot be utilized. {ECO 0000269|PubMed 10978348, ECO 0000269|PubMed 1648082, ECO 0000269|PubMed 21081498, ECO 0000269|PubMed 8020507}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0005525 GTP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0061603 molybdenum cofactor guanylyltransferase activity; IDA:EcoCyc. # GO_process GO:1902758 bis(molybdopterin guanine dinucleotide)molybdenum biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.90.550.10 -; 1. # HAMAP MF_00316 MobA # INDUCTION Is expressed at very low levels under both aerobic and anaerobic growth conditions. {ECO:0000269|PubMed 7551035}. # INTERACTION MOBA_ECOLI P12281 moeA; NbExp=3; IntAct=EBI-1133881, EBI-554393; # IntAct P32173 10 # InterPro IPR013482 Molybde_CF_guanTrfase # InterPro IPR025877 MobA-like_NTP_Trfase # InterPro IPR029044 Nucleotide-diphossugar_trans # KEGG_Brite ko01000 Enzymes # Organism MOBA_ECOLI Escherichia coli (strain K12) # PATRIC 32123211 VBIEscCol129921_3966 # PDB 1E5K X-ray; 1.35 A; A=1-194 # PDB 1FR9 X-ray; 1.65 A; A=1-194 # PDB 1FRW X-ray; 1.75 A; A=1-194 # PDB 1H4C X-ray; 1.65 A; A=1-194 # PDB 1H4D X-ray; 1.74 A; A=1-194 # PDB 1H4E X-ray; 1.65 A; A=1-194 # PDB 1HJJ X-ray; 1.65 A; A=1-194 # PDB 1HJL X-ray; 2.00 A; A=1-194 # PIR S40803 S40803 # Pfam PF12804 NTP_transf_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MOBA_ECOLI Molybdenum cofactor guanylyltransferase # RefSeq NP_418294 NC_000913.3 # RefSeq WP_001052181 NZ_LN832404.1 # SIMILARITY Belongs to the MobA family. {ECO 0000305}. # SUBCELLULAR LOCATION MOBA_ECOLI Cytoplasm. # SUBUNIT MOBA_ECOLI Monomer. An equilibrium exists between a monomeric and oligomeric form of the enzyme, which could be an octamer; whether this oligomeric arrangement is of functional relevance is unclear. Interacts with MoeA and MobB in vivo. {ECO 0000269|PubMed 10978347, ECO 0000269|PubMed 12372836, ECO 0000269|PubMed 8020507}. # SUPFAM SSF53448 SSF53448 # TIGRFAMs TIGR02665 molyb_mobA # eggNOG COG0746 LUCA # eggNOG ENOG4105C6R Bacteria BLAST swissprot:MOBA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MOBA_ECOLI BioCyc ECOL316407:JW3829-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3829-MONOMER BioCyc EcoCyc:EG11829-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11829-MONOMER BioCyc MetaCyc:EG11829-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11829-MONOMER COG COG0746 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0746 DIP DIP-10233N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10233N DOI 10.1016/S0969-2126(00)00518-9 http://dx.doi.org/10.1016/S0969-2126(00)00518-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M007406200 http://dx.doi.org/10.1074/jbc.M007406200 DOI 10.1074/jbc.M007407200 http://dx.doi.org/10.1074/jbc.M007407200 DOI 10.1074/jbc.M110.155671 http://dx.doi.org/10.1074/jbc.M110.155671 DOI 10.1074/jbc.M205806200 http://dx.doi.org/10.1074/jbc.M205806200 DOI 10.1074/jbc.M302639200 http://dx.doi.org/10.1074/jbc.M302639200 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1099/13500872-141-7-1663 http://dx.doi.org/10.1099/13500872-141-7-1663 DOI 10.1111/j.1432-1033.1994.tb18913.x http://dx.doi.org/10.1111/j.1432-1033.1994.tb18913.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.7.77 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.77 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.7.77 http://enzyme.expasy.org/EC/2.7.7.77 EchoBASE EB1776 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1776 EcoGene EG11829 http://www.ecogene.org/geneInfo.php?eg_id=EG11829 EnsemblBacteria AAC76855 http://www.ensemblgenomes.org/id/AAC76855 EnsemblBacteria AAC76855 http://www.ensemblgenomes.org/id/AAC76855 EnsemblBacteria BAE77451 http://www.ensemblgenomes.org/id/BAE77451 EnsemblBacteria BAE77451 http://www.ensemblgenomes.org/id/BAE77451 EnsemblBacteria BAE77451 http://www.ensemblgenomes.org/id/BAE77451 EnsemblBacteria b3857 http://www.ensemblgenomes.org/id/b3857 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_function GO:0061603 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061603 GO_process GO:1902758 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902758 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.90.550.10 http://www.cathdb.info/version/latest/superfamily/3.90.550.10 GeneID 948349 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948349 HAMAP MF_00316 http://hamap.expasy.org/unirule/MF_00316 HOGENOM HOG000280423 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000280423&db=HOGENOM6 InParanoid P32173 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32173 IntAct P32173 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32173* IntEnz 2.7.7.77 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.77 InterPro IPR013482 http://www.ebi.ac.uk/interpro/entry/IPR013482 InterPro IPR025877 http://www.ebi.ac.uk/interpro/entry/IPR025877 InterPro IPR029044 http://www.ebi.ac.uk/interpro/entry/IPR029044 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3829 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3829 KEGG_Gene eco:b3857 http://www.genome.jp/dbget-bin/www_bget?eco:b3857 KEGG_Orthology KO:K03752 http://www.genome.jp/dbget-bin/www_bget?KO:K03752 MINT MINT-1232345 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1232345 OMA DELPDFQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DELPDFQ PDB 1E5K http://www.ebi.ac.uk/pdbe-srv/view/entry/1E5K PDB 1FR9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1FR9 PDB 1FRW http://www.ebi.ac.uk/pdbe-srv/view/entry/1FRW PDB 1H4C http://www.ebi.ac.uk/pdbe-srv/view/entry/1H4C PDB 1H4D http://www.ebi.ac.uk/pdbe-srv/view/entry/1H4D PDB 1H4E http://www.ebi.ac.uk/pdbe-srv/view/entry/1H4E PDB 1HJJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1HJJ PDB 1HJL http://www.ebi.ac.uk/pdbe-srv/view/entry/1HJL PDBsum 1E5K http://www.ebi.ac.uk/pdbsum/1E5K PDBsum 1FR9 http://www.ebi.ac.uk/pdbsum/1FR9 PDBsum 1FRW http://www.ebi.ac.uk/pdbsum/1FRW PDBsum 1H4C http://www.ebi.ac.uk/pdbsum/1H4C PDBsum 1H4D http://www.ebi.ac.uk/pdbsum/1H4D PDBsum 1H4E http://www.ebi.ac.uk/pdbsum/1H4E PDBsum 1HJJ http://www.ebi.ac.uk/pdbsum/1HJJ PDBsum 1HJL http://www.ebi.ac.uk/pdbsum/1HJL PSORT swissprot:MOBA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MOBA_ECOLI PSORT-B swissprot:MOBA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MOBA_ECOLI PSORT2 swissprot:MOBA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MOBA_ECOLI Pfam PF12804 http://pfam.xfam.org/family/PF12804 Phobius swissprot:MOBA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MOBA_ECOLI PhylomeDB P32173 http://phylomedb.org/?seqid=P32173 ProteinModelPortal P32173 http://www.proteinmodelportal.org/query/uniprot/P32173 PubMed 10978347 http://www.ncbi.nlm.nih.gov/pubmed/10978347 PubMed 10978348 http://www.ncbi.nlm.nih.gov/pubmed/10978348 PubMed 11080634 http://www.ncbi.nlm.nih.gov/pubmed/11080634 PubMed 12372836 http://www.ncbi.nlm.nih.gov/pubmed/12372836 PubMed 12719427 http://www.ncbi.nlm.nih.gov/pubmed/12719427 PubMed 1648082 http://www.ncbi.nlm.nih.gov/pubmed/1648082 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21081498 http://www.ncbi.nlm.nih.gov/pubmed/21081498 PubMed 7551035 http://www.ncbi.nlm.nih.gov/pubmed/7551035 PubMed 8020507 http://www.ncbi.nlm.nih.gov/pubmed/8020507 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418294 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418294 RefSeq WP_001052181 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001052181 SMR P32173 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32173 STRING 511145.b3857 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3857&targetmode=cogs STRING COG0746 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0746&targetmode=cogs SUPFAM SSF53448 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53448 TIGRFAMs TIGR02665 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02665 UniProtKB MOBA_ECOLI http://www.uniprot.org/uniprot/MOBA_ECOLI UniProtKB-AC P32173 http://www.uniprot.org/uniprot/P32173 charge swissprot:MOBA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MOBA_ECOLI eggNOG COG0746 http://eggnogapi.embl.de/nog_data/html/tree/COG0746 eggNOG ENOG4105C6R http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C6R epestfind swissprot:MOBA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MOBA_ECOLI garnier swissprot:MOBA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MOBA_ECOLI helixturnhelix swissprot:MOBA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MOBA_ECOLI hmoment swissprot:MOBA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MOBA_ECOLI iep swissprot:MOBA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MOBA_ECOLI inforesidue swissprot:MOBA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MOBA_ECOLI octanol swissprot:MOBA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MOBA_ECOLI pepcoil swissprot:MOBA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MOBA_ECOLI pepdigest swissprot:MOBA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MOBA_ECOLI pepinfo swissprot:MOBA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MOBA_ECOLI pepnet swissprot:MOBA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MOBA_ECOLI pepstats swissprot:MOBA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MOBA_ECOLI pepwheel swissprot:MOBA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MOBA_ECOLI pepwindow swissprot:MOBA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MOBA_ECOLI sigcleave swissprot:MOBA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MOBA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261011 2 # EcoGene EG10047 apaG # Gene3D 2.60.40.1470 -; 1. # HAMAP MF_00791 ApaG # InterPro IPR007474 ApaG_domain # InterPro IPR023065 Uncharacterised_ApaG # Organism APAG_ECOLI Escherichia coli (strain K12) # PATRIC 32115199 VBIEscCol129921_0051 # PIR A30273 BVECAG # PROSITE PS51087 APAG # Pfam PF04379 DUF525 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName APAG_ECOLI Protein ApaG # RefSeq NP_414592 NC_000913.3 # RefSeq WP_000610901 NZ_LN832404.1 # SIMILARITY Contains 1 apaG domain. {ECO 0000305}. # SUPFAM SSF110069 SSF110069 # eggNOG COG2967 LUCA # eggNOG ENOG4105NWN Bacteria BLAST swissprot:APAG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:APAG_ECOLI BioCyc ECOL316407:JW0049-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0049-MONOMER BioCyc EcoCyc:EG10047-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10047-MONOMER COG COG2967 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2967 DOI 10.1007/BF00338091 http://dx.doi.org/10.1007/BF00338091 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X04711 http://www.ebi.ac.uk/ena/data/view/X04711 EchoBASE EB0045 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0045 EcoGene EG10047 http://www.ecogene.org/geneInfo.php?eg_id=EG10047 EnsemblBacteria AAC73161 http://www.ensemblgenomes.org/id/AAC73161 EnsemblBacteria AAC73161 http://www.ensemblgenomes.org/id/AAC73161 EnsemblBacteria BAB96618 http://www.ensemblgenomes.org/id/BAB96618 EnsemblBacteria BAB96618 http://www.ensemblgenomes.org/id/BAB96618 EnsemblBacteria BAB96618 http://www.ensemblgenomes.org/id/BAB96618 EnsemblBacteria b0050 http://www.ensemblgenomes.org/id/b0050 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 2.60.40.1470 http://www.cathdb.info/version/latest/superfamily/2.60.40.1470 GeneID 944772 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944772 HAMAP MF_00791 http://hamap.expasy.org/unirule/MF_00791 HOGENOM HOG000255805 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000255805&db=HOGENOM6 InParanoid P62672 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P62672 InterPro IPR007474 http://www.ebi.ac.uk/interpro/entry/IPR007474 InterPro IPR023065 http://www.ebi.ac.uk/interpro/entry/IPR023065 KEGG_Gene ecj:JW0049 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0049 KEGG_Gene eco:b0050 http://www.genome.jp/dbget-bin/www_bget?eco:b0050 KEGG_Orthology KO:K06195 http://www.genome.jp/dbget-bin/www_bget?KO:K06195 OMA GTMRGEY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GTMRGEY PROSITE PS51087 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51087 PSORT swissprot:APAG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:APAG_ECOLI PSORT-B swissprot:APAG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:APAG_ECOLI PSORT2 swissprot:APAG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:APAG_ECOLI Pfam PF04379 http://pfam.xfam.org/family/PF04379 Phobius swissprot:APAG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:APAG_ECOLI PhylomeDB P62672 http://phylomedb.org/?seqid=P62672 ProteinModelPortal P62672 http://www.proteinmodelportal.org/query/uniprot/P62672 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3031429 http://www.ncbi.nlm.nih.gov/pubmed/3031429 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414592 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414592 RefSeq WP_000610901 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000610901 SMR P62672 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P62672 STRING 511145.b0050 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0050&targetmode=cogs STRING COG2967 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2967&targetmode=cogs SUPFAM SSF110069 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF110069 UniProtKB APAG_ECOLI http://www.uniprot.org/uniprot/APAG_ECOLI UniProtKB-AC P62672 http://www.uniprot.org/uniprot/P62672 charge swissprot:APAG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:APAG_ECOLI eggNOG COG2967 http://eggnogapi.embl.de/nog_data/html/tree/COG2967 eggNOG ENOG4105NWN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105NWN epestfind swissprot:APAG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:APAG_ECOLI garnier swissprot:APAG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:APAG_ECOLI helixturnhelix swissprot:APAG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:APAG_ECOLI hmoment swissprot:APAG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:APAG_ECOLI iep swissprot:APAG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:APAG_ECOLI inforesidue swissprot:APAG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:APAG_ECOLI octanol swissprot:APAG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:APAG_ECOLI pepcoil swissprot:APAG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:APAG_ECOLI pepdigest swissprot:APAG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:APAG_ECOLI pepinfo swissprot:APAG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:APAG_ECOLI pepnet swissprot:APAG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:APAG_ECOLI pepstats swissprot:APAG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:APAG_ECOLI pepwheel swissprot:APAG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:APAG_ECOLI pepwindow swissprot:APAG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:APAG_ECOLI sigcleave swissprot:APAG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:APAG_ECOLI ## Database ID URL or Descriptions # AltName CURA_ECOLI NADPH-dependent curcumin/dihydrocurcumin reductase # BIOPHYSICOCHEMICAL PROPERTIES CURA_ECOLI Kinetic parameters KM=29 uM for curcumin {ECO 0000269|PubMed 21467222}; Vmax=9.35 umol/min/mg enzyme {ECO 0000269|PubMed 21467222}; pH dependence Optimum pH is 5.9. The enzyme is most stable in the pH range of 4.5 to 12.0, with 90% of the initial activity being retained even at pH 12.0. {ECO 0000269|PubMed 21467222}; Temperature dependence Optimum temperature is 35 degrees Celsius. The enzyme is most stable from 10 to 50 degrees Celsius. {ECO 0000269|PubMed 21467222}; # BioGrid 4260195 6 # CATALYTIC ACTIVITY Tetrahydrocurcumin + 2 NADP(+) = curcumin + 2 NADPH. {ECO:0000269|PubMed 21467222}. # ENZYME REGULATION Inhibited by thiol-specific reagents (p- chloromercuribenzoate and 5,5'-dithio-bis-2-nitrobenzoate). {ECO:0000269|PubMed 21467222}. # EcoGene EG13772 curA # FUNCTION CURA_ECOLI Catalyzes the metal-independent reduction of curcumin to dihydrocurcumin (DHC) as an intermediate product, followed by further reduction to tetrahydrocurcumin (THC) as an end product. It also acts on 3-octene-2-one, 3-hepten-2-one, resveratrol, and trans-2-octenal. {ECO 0000269|PubMed 21467222}. # GO_function GO:0008270 zinc ion binding; IEA:InterPro. # GO_function GO:0016631 enoyl-[acyl-carrier-protein] reductase activity; IEA:UniProtKB-EC. # GO_function GO:0018498 2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase activity; IEA:UniProtKB-EC. # GO_function GO:0018499 cis-2,3-dihydrodiol DDT dehydrogenase activity; IEA:UniProtKB-EC. # GO_function GO:0018500 trans-9R,10R-dihydrodiolphenanthrene dehydrogenase activity; IEA:UniProtKB-EC. # GO_function GO:0018501 cis-chlorobenzene dihydrodiol dehydrogenase activity; IEA:UniProtKB-EC. # GO_function GO:0018502 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase activity; IEA:UniProtKB-EC. # GO_function GO:0018503 trans-1,2-dihydrodiolphenanthrene dehydrogenase activity; IEA:UniProtKB-EC. # GO_function GO:0034790 3,4-dihydroxy-3,4-dihydrofluorene dehydrogenase activity; IEA:UniProtKB-EC. # GO_function GO:0034805 benzo(a)pyrene-trans-11,12-dihydrodiol dehydrogenase activity; IEA:UniProtKB-EC. # GO_function GO:0034809 benzo(a)pyrene-cis-4,5-dihydrodiol dehydrogenase activity; IEA:UniProtKB-EC. # GO_function GO:0034824 citronellyl-CoA dehydrogenase activity; IEA:UniProtKB-EC. # GO_function GO:0034838 menthone dehydrogenase activity; IEA:UniProtKB-EC. # GO_function GO:0034912 phthalate 3,4-cis-dihydrodiol dehydrogenase activity; IEA:UniProtKB-EC. # GO_function GO:0043786 cinnamate reductase activity; IEA:UniProtKB-EC. # GO_function GO:0052849 NADPH-dependent curcumin reductase activity; IEA:UniProtKB-EC. # GO_function GO:0052850 NADPH-dependent dihydrocurcumin reductase activity; IEA:UniProtKB-EC. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.720 -; 1. # Gene3D 3.90.180.10 -; 1. # InterPro IPR002085 ADH_SF_Zn-type # InterPro IPR011032 GroES-like # InterPro IPR013149 ADH_C # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR020843 PKS_ER # MASS SPECTROMETRY Mass=37513; Method=MALDI; Range=1-345; Evidence={ECO:0000269|PubMed 21467222}; # Organism CURA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11695 PTHR11695 # PATRIC 32118190 VBIEscCol129921_1515 # PIR D64897 D64897 # Pfam PF00107 ADH_zinc_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CURA_ECOLI NADPH-dependent curcumin reductase # RefSeq NP_415966 NC_000913.3 # RefSeq WP_000531462 NZ_LN832404.1 # SIMILARITY Belongs to the NADP-dependent oxidoreductase L4BD family. {ECO 0000305}. # SMART SM00829 PKS_ER # SUBUNIT Homodimer. {ECO:0000269|PubMed 21467222}. # SUPFAM SSF50129 SSF50129; 2 # SUPFAM SSF51735 SSF51735 # eggNOG COG2130 LUCA # eggNOG ENOG4105CJH Bacteria BLAST swissprot:CURA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CURA_ECOLI BioCyc ECOL316407:JW5907-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5907-MONOMER BioCyc EcoCyc:G6760-MONOMER http://biocyc.org/getid?id=EcoCyc:G6760-MONOMER BioCyc MetaCyc:G6760-MONOMER http://biocyc.org/getid?id=MetaCyc:G6760-MONOMER COG COG2130 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2130 DIP DIP-12748N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12748N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.1016217108 http://dx.doi.org/10.1073/pnas.1016217108 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.3.1.n3 http://www.genome.jp/dbget-bin/www_bget?EC:1.3.1.n3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.3.1.n3 http://enzyme.expasy.org/EC/1.3.1.n3 EchoBASE EB3534 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3534 EcoGene EG13772 http://www.ecogene.org/geneInfo.php?eg_id=EG13772 EnsemblBacteria AAC74531 http://www.ensemblgenomes.org/id/AAC74531 EnsemblBacteria AAC74531 http://www.ensemblgenomes.org/id/AAC74531 EnsemblBacteria BAA15081 http://www.ensemblgenomes.org/id/BAA15081 EnsemblBacteria BAA15081 http://www.ensemblgenomes.org/id/BAA15081 EnsemblBacteria BAA15081 http://www.ensemblgenomes.org/id/BAA15081 EnsemblBacteria b1449 http://www.ensemblgenomes.org/id/b1449 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0016631 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016631 GO_function GO:0018498 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018498 GO_function GO:0018499 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018499 GO_function GO:0018500 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018500 GO_function GO:0018501 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018501 GO_function GO:0018502 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018502 GO_function GO:0018503 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018503 GO_function GO:0034790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034790 GO_function GO:0034805 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034805 GO_function GO:0034809 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034809 GO_function GO:0034824 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034824 GO_function GO:0034838 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034838 GO_function GO:0034912 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034912 GO_function GO:0043786 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043786 GO_function GO:0052849 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052849 GO_function GO:0052850 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052850 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 Gene3D 3.90.180.10 http://www.cathdb.info/version/latest/superfamily/3.90.180.10 GeneID 946012 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946012 HOGENOM HOG000294663 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000294663&db=HOGENOM6 InParanoid P76113 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76113 IntEnz 1.3.1.n3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.3.1.n3 InterPro IPR002085 http://www.ebi.ac.uk/interpro/entry/IPR002085 InterPro IPR011032 http://www.ebi.ac.uk/interpro/entry/IPR011032 InterPro IPR013149 http://www.ebi.ac.uk/interpro/entry/IPR013149 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR020843 http://www.ebi.ac.uk/interpro/entry/IPR020843 KEGG_Gene ecj:JW5907 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5907 KEGG_Gene eco:b1449 http://www.genome.jp/dbget-bin/www_bget?eco:b1449 KEGG_Orthology KO:K07119 http://www.genome.jp/dbget-bin/www_bget?KO:K07119 PANTHER PTHR11695 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11695 PSORT swissprot:CURA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CURA_ECOLI PSORT-B swissprot:CURA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CURA_ECOLI PSORT2 swissprot:CURA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CURA_ECOLI Pfam PF00107 http://pfam.xfam.org/family/PF00107 Phobius swissprot:CURA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CURA_ECOLI PhylomeDB P76113 http://phylomedb.org/?seqid=P76113 ProteinModelPortal P76113 http://www.proteinmodelportal.org/query/uniprot/P76113 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21467222 http://www.ncbi.nlm.nih.gov/pubmed/21467222 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415966 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415966 RefSeq WP_000531462 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000531462 SMART SM00829 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00829 SMR P76113 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76113 STRING 511145.b1449 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1449&targetmode=cogs STRING COG2130 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2130&targetmode=cogs SUPFAM SSF50129 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50129 SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB CURA_ECOLI http://www.uniprot.org/uniprot/CURA_ECOLI UniProtKB-AC P76113 http://www.uniprot.org/uniprot/P76113 charge swissprot:CURA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CURA_ECOLI eggNOG COG2130 http://eggnogapi.embl.de/nog_data/html/tree/COG2130 eggNOG ENOG4105CJH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CJH epestfind swissprot:CURA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CURA_ECOLI garnier swissprot:CURA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CURA_ECOLI helixturnhelix swissprot:CURA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CURA_ECOLI hmoment swissprot:CURA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CURA_ECOLI iep swissprot:CURA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CURA_ECOLI inforesidue swissprot:CURA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CURA_ECOLI octanol swissprot:CURA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CURA_ECOLI pepcoil swissprot:CURA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CURA_ECOLI pepdigest swissprot:CURA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CURA_ECOLI pepinfo swissprot:CURA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CURA_ECOLI pepnet swissprot:CURA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CURA_ECOLI pepstats swissprot:CURA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CURA_ECOLI pepwheel swissprot:CURA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CURA_ECOLI pepwindow swissprot:CURA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CURA_ECOLI sigcleave swissprot:CURA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CURA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261100 5 # EcoGene EG11854 yiiE # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:InterPro. # GOslim_process GO:0008150 biological_process # InterPro IPR002145 CopG # Organism YIIE_ECOLI Escherichia coli (strain K12) # PATRIC 32123283 VBIEscCol129921_4002 # PIR S40833 S40833 # Pfam PF01402 RHH_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIIE_ECOLI Uncharacterized protein YiiE # RefSeq NP_418325 NC_000913.3 # RefSeq WP_001295676 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB03022.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAD13451.3; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the YiiE family. {ECO 0000305}. BLAST swissprot:YIIE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIIE_ECOLI BioCyc ECOL316407:JW5929-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5929-MONOMER BioCyc EcoCyc:EG11854-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11854-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1800 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1800 EcoGene EG11854 http://www.ecogene.org/geneInfo.php?eg_id=EG11854 EnsemblBacteria AAD13451 http://www.ensemblgenomes.org/id/AAD13451 EnsemblBacteria AAD13451 http://www.ensemblgenomes.org/id/AAD13451 EnsemblBacteria BAE77420 http://www.ensemblgenomes.org/id/BAE77420 EnsemblBacteria BAE77420 http://www.ensemblgenomes.org/id/BAE77420 EnsemblBacteria BAE77420 http://www.ensemblgenomes.org/id/BAE77420 EnsemblBacteria b3889 http://www.ensemblgenomes.org/id/b3889 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 948386 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948386 HOGENOM HOG000169463 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000169463&db=HOGENOM6 InterPro IPR002145 http://www.ebi.ac.uk/interpro/entry/IPR002145 KEGG_Gene ecj:JW5929 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5929 KEGG_Gene eco:b3889 http://www.genome.jp/dbget-bin/www_bget?eco:b3889 OMA MNSICKV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MNSICKV OrthoDB EOG6MSS87 http://cegg.unige.ch/orthodb/results?searchtext=EOG6MSS87 PSORT swissprot:YIIE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIIE_ECOLI PSORT-B swissprot:YIIE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIIE_ECOLI PSORT2 swissprot:YIIE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIIE_ECOLI Pfam PF01402 http://pfam.xfam.org/family/PF01402 Phobius swissprot:YIIE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIIE_ECOLI ProteinModelPortal P0ADQ5 http://www.proteinmodelportal.org/query/uniprot/P0ADQ5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418325 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418325 RefSeq WP_001295676 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295676 SMR P0ADQ5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADQ5 STRING 511145.b3889 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3889&targetmode=cogs UniProtKB YIIE_ECOLI http://www.uniprot.org/uniprot/YIIE_ECOLI UniProtKB-AC P0ADQ5 http://www.uniprot.org/uniprot/P0ADQ5 charge swissprot:YIIE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIIE_ECOLI epestfind swissprot:YIIE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIIE_ECOLI garnier swissprot:YIIE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIIE_ECOLI helixturnhelix swissprot:YIIE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIIE_ECOLI hmoment swissprot:YIIE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIIE_ECOLI iep swissprot:YIIE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIIE_ECOLI inforesidue swissprot:YIIE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIIE_ECOLI octanol swissprot:YIIE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIIE_ECOLI pepcoil swissprot:YIIE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIIE_ECOLI pepdigest swissprot:YIIE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIIE_ECOLI pepinfo swissprot:YIIE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIIE_ECOLI pepnet swissprot:YIIE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIIE_ECOLI pepstats swissprot:YIIE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIIE_ECOLI pepwheel swissprot:YIIE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIIE_ECOLI pepwindow swissprot:YIIE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIIE_ECOLI sigcleave swissprot:YIIE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIIE_ECOLI ## Database ID URL or Descriptions # EcoGene EG10865 rplB # FUNCTION RL2_ECOLI In the E.coli 70S ribosome in the initiation state it has been modeled to make several contacts with the 16S rRNA (forming bridge B7b, PubMed 12809609); these contacts are broken in the model with bound EF-G. {ECO 0000269|PubMed 12809609}. # FUNCTION RL2_ECOLI One of the primary rRNA binding proteins. Located near the base of the L1 stalk, it is probably also mobile. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is highly controversial. {ECO 0000269|PubMed 10756104, ECO 0000269|PubMed 11013226, ECO 0000269|PubMed 11114255, ECO 0000269|PubMed 12809609, ECO 0000269|PubMed 16272117, ECO 0000269|PubMed 3298242}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0022625 cytosolic large ribosomal subunit; IDA:EcoCyc. # GO_function GO:0003735 structural constituent of ribosome; IBA:GO_Central. # GO_function GO:0008270 zinc ion binding; IDA:EcoliWiki. # GO_function GO:0016740 transferase activity; IEA:InterPro. # GO_function GO:0019843 rRNA binding; IEA:UniProtKB-HAMAP. # GO_process GO:0002181 cytoplasmic translation; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_function GO:0019843 rRNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006412 translation # Gene3D 2.30.30.30 -; 1. # Gene3D 4.10.950.10 -; 1. # HAMAP MF_01320_B Ribosomal_L2_B # INTERACTION RL2_ECOLI P03004 dnaA; NbExp=4; IntAct=EBI-543515, EBI-548951; P45759 gspE; NbExp=2; IntAct=EBI-543515, EBI-1132437; P00959 metG; NbExp=2; IntAct=EBI-543515, EBI-909268; P0A7Z4 rpoA; NbExp=5; IntAct=EBI-543515, EBI-544985; # IntAct P60422 362 # InterPro IPR002171 Ribosomal_L2 # InterPro IPR005880 Ribosomal_L2_bac/org-type # InterPro IPR008991 Translation_prot_SH3-like # InterPro IPR012340 NA-bd_OB-fold # InterPro IPR014722 Rib_L2_dom2 # InterPro IPR014726 Ribosomal_L2_dom3 # InterPro IPR022666 Rbsml_prot_L2_RNA-bd_dom # InterPro IPR022669 Ribosomal_L2_C # InterPro IPR022671 Ribosomal_L2_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 M00179 Ribosome, archaea # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=29732.3; Method=MALDI; Range=2-273; Evidence={ECO:0000269|PubMed 10094780}; # MISCELLANEOUS This protein can be partially replaced in vivo by its H.marismortui (HmaL2) or human (L8, from the 60S cytoplasmic ribosome) homolog. {ECO:0000269|PubMed 9531480}. # Organism RL2_ECOLI Escherichia coli (strain K12) # PANTHER PTHR13691 PTHR13691 # PATRIC 32122066 VBIEscCol129921_3410 # PDB 2J28 EM; 8.00 A; C=4-270 # PDB 2RDO EM; 9.10 A; C=2-273 # PDB 3BBX EM; 10.00 A; C=1-273 # PDB 3J5L EM; 6.60 A; C=2-272 # PDB 3J7Z EM; 3.90 A; C=1-273 # PDB 3J8G EM; 5.00 A; C=1-273 # PDB 3J9Y EM; 3.90 A; C=1-273 # PDB 3J9Z EM; 3.60 A; LN=2-273 # PDB 3JA1 EM; 3.60 A; LD=2-273 # PDB 3JBU EM; 3.64 A; c=1-273 # PDB 3JBV EM; 3.32 A; c=1-273 # PDB 3JCD EM; 3.70 A; C=1-273 # PDB 3JCE EM; 3.20 A; C=1-273 # PDB 3JCJ EM; 3.70 A; B=1-273 # PDB 3JCN EM; 4.60 A; C=1-273 # PDB 487D EM; 7.50 A; I=62-172 # PDB 4CSU EM; 5.50 A; C=2-273 # PDB 4U1U X-ray; 2.95 A; BC/DC=2-272 # PDB 4U1V X-ray; 3.00 A; BC/DC=2-272 # PDB 4U20 X-ray; 2.90 A; BC/DC=2-272 # PDB 4U24 X-ray; 2.90 A; BC/DC=2-272 # PDB 4U25 X-ray; 2.90 A; BC/DC=2-272 # PDB 4U26 X-ray; 2.80 A; BC/DC=2-272 # PDB 4U27 X-ray; 2.80 A; BC/DC=2-272 # PDB 4UY8 EM; 3.80 A; C=2-272 # PDB 4V47 EM; 12.30 A; AA=2-273 # PDB 4V48 EM; 11.50 A; AA=2-273 # PDB 4V4H X-ray; 3.46 A; BC/DC=1-273 # PDB 4V4Q X-ray; 3.46 A; BC/DC=1-273 # PDB 4V4V EM; 15.00 A; BA=39-265 # PDB 4V4W EM; 15.00 A; BA=39-265 # PDB 4V50 X-ray; 3.22 A; BC/DC=2-273 # PDB 4V52 X-ray; 3.21 A; BC/DC=2-273 # PDB 4V53 X-ray; 3.54 A; BC/DC=2-273 # PDB 4V54 X-ray; 3.30 A; BC/DC=2-273 # PDB 4V55 X-ray; 4.00 A; BC/DC=2-273 # PDB 4V56 X-ray; 3.93 A; BC/DC=2-273 # PDB 4V57 X-ray; 3.50 A; BC/DC=2-273 # PDB 4V5B X-ray; 3.74 A; AC/CC=1-273 # PDB 4V5H EM; 5.80 A; BC=2-272 # PDB 4V5Y X-ray; 4.45 A; BC/DC=2-273 # PDB 4V64 X-ray; 3.50 A; BC/DC=1-273 # PDB 4V65 EM; 9.00 A; BN=1-270 # PDB 4V66 EM; 9.00 A; BN=1-270 # PDB 4V69 EM; 6.70 A; BC=2-272 # PDB 4V6C X-ray; 3.19 A; BC/DC=1-273 # PDB 4V6D X-ray; 3.81 A; BC/DC=1-273 # PDB 4V6E X-ray; 3.71 A; BC/DC=1-273 # PDB 4V6K EM; 8.25 A; AD=1-273 # PDB 4V6L EM; 13.20 A; BD=1-273 # PDB 4V6M EM; 7.10 A; B6=2-273 # PDB 4V6N EM; 12.10 A; AD=2-273 # PDB 4V6O EM; 14.70 A; BD=2-273 # PDB 4V6P EM; 13.50 A; BD=2-273 # PDB 4V6Q EM; 11.50 A; BD=2-273 # PDB 4V6R EM; 11.50 A; BD=2-273 # PDB 4V6S EM; 13.10 A; AD=2-273 # PDB 4V6T EM; 8.30 A; BC=2-272 # PDB 4V6V EM; 9.80 A; BD=2-273 # PDB 4V6Y EM; 12.00 A; BC=1-272 # PDB 4V6Z EM; 12.00 A; BC=1-272 # PDB 4V70 EM; 17.00 A; BC=1-272 # PDB 4V71 EM; 20.00 A; BC=1-272 # PDB 4V72 EM; 13.00 A; BC=1-272 # PDB 4V73 EM; 15.00 A; BC=1-272 # PDB 4V74 EM; 17.00 A; BC=1-272 # PDB 4V75 EM; 12.00 A; BC=1-272 # PDB 4V76 EM; 17.00 A; BC=1-272 # PDB 4V77 EM; 17.00 A; BC=1-272 # PDB 4V78 EM; 20.00 A; BC=1-272 # PDB 4V79 EM; 15.00 A; BC=1-272 # PDB 4V7A EM; 9.00 A; BC=1-272 # PDB 4V7B EM; 6.80 A; BC=1-273 # PDB 4V7C EM; 7.60 A; BD=2-273 # PDB 4V7D EM; 7.60 A; AD=2-273 # PDB 4V7I EM; 9.60 A; A6=1-273 # PDB 4V7S X-ray; 3.25 A; BC/DC=2-272 # PDB 4V7T X-ray; 3.19 A; BC/DC=2-272 # PDB 4V7U X-ray; 3.10 A; BC/DC=2-272 # PDB 4V7V X-ray; 3.29 A; BC/DC=2-272 # PDB 4V85 X-ray; 3.20 A; C=1-273 # PDB 4V89 X-ray; 3.70 A; BC=1-273 # PDB 4V9C X-ray; 3.30 A; BC/DC=1-273 # PDB 4V9D X-ray; 3.00 A; CC/DC=2-272 # PDB 4V9O X-ray; 2.90 A; AC/CC/EC/GC=1-273 # PDB 4V9P X-ray; 2.90 A; AC/CC/EC/GC=1-273 # PDB 4WF1 X-ray; 3.09 A; BC/DC=2-272 # PDB 4WOI X-ray; 3.00 A; BC/CC=1-273 # PDB 4WWW X-ray; 3.10 A; RC/YC=2-272 # PDB 4YBB X-ray; 2.10 A; CC/DC=2-272 # PDB 5ADY EM; 4.50 A; C=1-273 # PDB 5AFI EM; 2.90 A; C=1-273 # PDB 5AKA EM; 5.70 A; C=1-273 # PDB 5GAD EM; 3.70 A; C=1-273 # PDB 5GAE EM; 3.33 A; C=1-273 # PDB 5GAF EM; 4.30 A; C=2-272 # PDB 5GAG EM; 3.80 A; C=1-273 # PDB 5GAH EM; 3.80 A; C=1-273 # PDB 5IQR EM; 3.00 A; B=1-273 # PDB 5IT8 X-ray; 3.12 A; CC/DC=2-272 # PDB 5J5B X-ray; 2.80 A; CC/DC=2-272 # PDB 5J7L X-ray; 3.00 A; CC/DC=2-272 # PDB 5J88 X-ray; 3.32 A; CC/DC=2-273 # PDB 5J8A X-ray; 3.10 A; CC/DC=2-273 # PDB 5J91 X-ray; 2.96 A; CC/DC=2-273 # PDB 5JC9 X-ray; 3.03 A; CC/DC=2-272 # PDB 5JTE EM; 3.60 A; BC=1-273 # PDB 5JU8 EM; 3.60 A; BC=1-273 # PDB 5KCR EM; 3.60 A; 1D=1-273 # PDB 5KCS EM; 3.90 A; 1D=1-273 # PDB 5KPS EM; 3.90 A; B=1-273 # PDB 5KPV EM; 4.10 A; A=1-273 # PDB 5KPW EM; 3.90 A; A=1-273 # PDB 5KPX EM; 3.90 A; A=1-273 # PDB 5L3P EM; 3.70 A; D=1-273 # PIR E23129 R5EC2 # PIRSF PIRSF002158 Ribosomal_L2 # PROSITE PS00467 RIBOSOMAL_L2 # Pfam PF00181 Ribosomal_L2 # Pfam PF03947 Ribosomal_L2_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RL2_ECOLI 50S ribosomal protein L2 # RefSeq NP_417776 NC_000913.3 # RefSeq WP_000301864 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein L2P family. {ECO 0000305}. # SMART SM01382 Ribosomal_L2_C # SMART SM01383 Ribosomal_L2 # SUBUNIT Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome, contacting the 16S rRNA. Interacts weakly with S6 in one of the 3.5 A resolved structures. {ECO:0000269|PubMed 12809609}. # SUPFAM SSF50104 SSF50104 # SUPFAM SSF50249 SSF50249 # TIGRFAMs TIGR01171 rplB_bact # eggNOG COG0090 LUCA # eggNOG ENOG4105CFD Bacteria BLAST swissprot:RL2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RL2_ECOLI BioCyc ECOL316407:JW3279-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3279-MONOMER BioCyc EcoCyc:EG10865-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10865-MONOMER BioCyc MetaCyc:EG10865-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10865-MONOMER COG COG0090 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0090 DIP DIP-35747N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35747N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1006/jmbi.2000.3635 http://dx.doi.org/10.1006/jmbi.2000.3635 DOI 10.1006/jmbi.2000.4289 http://dx.doi.org/10.1006/jmbi.2000.4289 DOI 10.1016/S0092-8674(03)00427-6 http://dx.doi.org/10.1016/S0092-8674(03)00427-6 DOI 10.1016/j.celrep.2014.09.011 http://dx.doi.org/10.1016/j.celrep.2014.09.011 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj3310423 http://dx.doi.org/10.1042/bj3310423 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/emboj/19.19.5241 http://dx.doi.org/10.1093/emboj/19.19.5241 DOI 10.1093/nar/13.12.4521 http://dx.doi.org/10.1093/nar/13.12.4521 DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1139/o95-117 http://dx.doi.org/10.1139/o95-117 DOI 10.1371/journal.pbio.1001866 http://dx.doi.org/10.1371/journal.pbio.1001866 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X02613 http://www.ebi.ac.uk/ena/data/view/X02613 EchoBASE EB0858 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0858 EcoGene EG10865 http://www.ecogene.org/geneInfo.php?eg_id=EG10865 EnsemblBacteria AAC76342 http://www.ensemblgenomes.org/id/AAC76342 EnsemblBacteria AAC76342 http://www.ensemblgenomes.org/id/AAC76342 EnsemblBacteria BAE77974 http://www.ensemblgenomes.org/id/BAE77974 EnsemblBacteria BAE77974 http://www.ensemblgenomes.org/id/BAE77974 EnsemblBacteria BAE77974 http://www.ensemblgenomes.org/id/BAE77974 EnsemblBacteria b3317 http://www.ensemblgenomes.org/id/b3317 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0022625 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022625 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0016740 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016740 GO_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GO_process GO:0002181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002181 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 Gene3D 2.30.30.30 http://www.cathdb.info/version/latest/superfamily/2.30.30.30 Gene3D 4.10.950.10 http://www.cathdb.info/version/latest/superfamily/4.10.950.10 GeneID 5548832 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5548832 GeneID 947820 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947820 HAMAP MF_01320_B http://hamap.expasy.org/unirule/MF_01320_B HOGENOM HOG000232982 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000232982&db=HOGENOM6 InParanoid P60422 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P60422 IntAct P60422 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P60422* InterPro IPR002171 http://www.ebi.ac.uk/interpro/entry/IPR002171 InterPro IPR005880 http://www.ebi.ac.uk/interpro/entry/IPR005880 InterPro IPR008991 http://www.ebi.ac.uk/interpro/entry/IPR008991 InterPro IPR012340 http://www.ebi.ac.uk/interpro/entry/IPR012340 InterPro IPR014722 http://www.ebi.ac.uk/interpro/entry/IPR014722 InterPro IPR014726 http://www.ebi.ac.uk/interpro/entry/IPR014726 InterPro IPR022666 http://www.ebi.ac.uk/interpro/entry/IPR022666 InterPro IPR022669 http://www.ebi.ac.uk/interpro/entry/IPR022669 InterPro IPR022671 http://www.ebi.ac.uk/interpro/entry/IPR022671 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW3279 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3279 KEGG_Gene eco:b3317 http://www.genome.jp/dbget-bin/www_bget?eco:b3317 KEGG_Orthology KO:K02886 http://www.genome.jp/dbget-bin/www_bget?KO:K02886 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 MINT MINT-1322809 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1322809 OMA PIKAGNN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PIKAGNN PANTHER PTHR13691 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13691 PDB 2J28 http://www.ebi.ac.uk/pdbe-srv/view/entry/2J28 PDB 2RDO http://www.ebi.ac.uk/pdbe-srv/view/entry/2RDO PDB 3BBX http://www.ebi.ac.uk/pdbe-srv/view/entry/3BBX PDB 3J5L http://www.ebi.ac.uk/pdbe-srv/view/entry/3J5L PDB 3J7Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J7Z PDB 3J8G http://www.ebi.ac.uk/pdbe-srv/view/entry/3J8G PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 487D http://www.ebi.ac.uk/pdbe-srv/view/entry/487D PDB 4CSU http://www.ebi.ac.uk/pdbe-srv/view/entry/4CSU PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4UY8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4UY8 PDB 4V47 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V47 PDB 4V48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V48 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5ADY http://www.ebi.ac.uk/pdbe-srv/view/entry/5ADY PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5AKA http://www.ebi.ac.uk/pdbe-srv/view/entry/5AKA PDB 5GAD http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAD PDB 5GAE http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAE PDB 5GAF http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAF PDB 5GAG http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAG PDB 5GAH http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAH PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 2J28 http://www.ebi.ac.uk/pdbsum/2J28 PDBsum 2RDO http://www.ebi.ac.uk/pdbsum/2RDO PDBsum 3BBX http://www.ebi.ac.uk/pdbsum/3BBX PDBsum 3J5L http://www.ebi.ac.uk/pdbsum/3J5L PDBsum 3J7Z http://www.ebi.ac.uk/pdbsum/3J7Z PDBsum 3J8G http://www.ebi.ac.uk/pdbsum/3J8G PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 487D http://www.ebi.ac.uk/pdbsum/487D PDBsum 4CSU http://www.ebi.ac.uk/pdbsum/4CSU PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4UY8 http://www.ebi.ac.uk/pdbsum/4UY8 PDBsum 4V47 http://www.ebi.ac.uk/pdbsum/4V47 PDBsum 4V48 http://www.ebi.ac.uk/pdbsum/4V48 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5ADY http://www.ebi.ac.uk/pdbsum/5ADY PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5AKA http://www.ebi.ac.uk/pdbsum/5AKA PDBsum 5GAD http://www.ebi.ac.uk/pdbsum/5GAD PDBsum 5GAE http://www.ebi.ac.uk/pdbsum/5GAE PDBsum 5GAF http://www.ebi.ac.uk/pdbsum/5GAF PDBsum 5GAG http://www.ebi.ac.uk/pdbsum/5GAG PDBsum 5GAH http://www.ebi.ac.uk/pdbsum/5GAH PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PROSITE PS00467 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00467 PSORT swissprot:RL2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RL2_ECOLI PSORT-B swissprot:RL2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RL2_ECOLI PSORT2 swissprot:RL2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RL2_ECOLI Pfam PF00181 http://pfam.xfam.org/family/PF00181 Pfam PF03947 http://pfam.xfam.org/family/PF03947 Phobius swissprot:RL2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RL2_ECOLI PhylomeDB P60422 http://phylomedb.org/?seqid=P60422 ProteinModelPortal P60422 http://www.proteinmodelportal.org/query/uniprot/P60422 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 10756104 http://www.ncbi.nlm.nih.gov/pubmed/10756104 PubMed 11013226 http://www.ncbi.nlm.nih.gov/pubmed/11013226 PubMed 11114255 http://www.ncbi.nlm.nih.gov/pubmed/11114255 PubMed 12809609 http://www.ncbi.nlm.nih.gov/pubmed/12809609 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 24844575 http://www.ncbi.nlm.nih.gov/pubmed/24844575 PubMed 25310980 http://www.ncbi.nlm.nih.gov/pubmed/25310980 PubMed 3298242 http://www.ncbi.nlm.nih.gov/pubmed/3298242 PubMed 3892488 http://www.ncbi.nlm.nih.gov/pubmed/3892488 PubMed 7556101 http://www.ncbi.nlm.nih.gov/pubmed/7556101 PubMed 8722025 http://www.ncbi.nlm.nih.gov/pubmed/8722025 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9531480 http://www.ncbi.nlm.nih.gov/pubmed/9531480 RefSeq NP_417776 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417776 RefSeq WP_000301864 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000301864 SMART SM01382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01382 SMART SM01383 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01383 SMR P60422 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P60422 STRING 511145.b3317 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3317&targetmode=cogs STRING COG0090 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0090&targetmode=cogs SUPFAM SSF50104 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50104 SUPFAM SSF50249 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50249 TIGRFAMs TIGR01171 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01171 UniProtKB RL2_ECOLI http://www.uniprot.org/uniprot/RL2_ECOLI UniProtKB-AC P60422 http://www.uniprot.org/uniprot/P60422 charge swissprot:RL2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RL2_ECOLI eggNOG COG0090 http://eggnogapi.embl.de/nog_data/html/tree/COG0090 eggNOG ENOG4105CFD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CFD epestfind swissprot:RL2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RL2_ECOLI garnier swissprot:RL2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RL2_ECOLI helixturnhelix swissprot:RL2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RL2_ECOLI hmoment swissprot:RL2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RL2_ECOLI iep swissprot:RL2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RL2_ECOLI inforesidue swissprot:RL2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RL2_ECOLI octanol swissprot:RL2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RL2_ECOLI pepcoil swissprot:RL2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RL2_ECOLI pepdigest swissprot:RL2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RL2_ECOLI pepinfo swissprot:RL2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RL2_ECOLI pepnet swissprot:RL2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RL2_ECOLI pepstats swissprot:RL2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RL2_ECOLI pepwheel swissprot:RL2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RL2_ECOLI pepwindow swissprot:RL2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RL2_ECOLI sigcleave swissprot:RL2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RL2_ECOLI ## Database ID URL or Descriptions # BRENDA 3.5.3.26 2026 # BioGrid 4262016 7 # CATALYTIC ACTIVITY (S)-2-ureidoglycine + H(2)O = (S)- ureidoglycolate + NH(3). {ECO:0000269|PubMed 19935661}. # COFACTOR ALLE_ECOLI Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 20038185}; # EcoGene EG13622 ylbA # FUNCTION ALLE_ECOLI Involved in the catabolism of purine nucleotides. Catalyzes the second, stereospecific hydrolysis reaction of the allantoin degradation pathway, producing S-ureidoglycolate and ammonia from S-ureidoglycine. {ECO 0000269|PubMed 19935661, ECO 0000269|PubMed 20038185}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0030145 manganese ion binding; IDA:EcoCyc. # GO_function GO:0071522 ureidoglycine aminohydrolase activity; IDA:EcoCyc. # GO_process GO:0006144 purine nucleobase metabolic process; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 2.60.120.10 -; 1. # INDUCTION By glyoxylate and allantoin under anaerobic conditions. {ECO:0000269|PubMed 10601204}. # IntAct P75713 7 # InterPro IPR008579 DUF861_Cupin_3 # InterPro IPR011051 RmlC_Cupin # InterPro IPR013096 Cupin_2 # InterPro IPR014710 RmlC-like_jellyroll # InterPro IPR017627 CHP03214_cupin # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # Organism ALLE_ECOLI Escherichia coli (strain K12) # PATRIC 32116187 VBIEscCol129921_0535 # PDB 1RC6 X-ray; 2.60 A; A/B=1-261 # PIR B64783 B64783 # Pfam PF05899 Cupin_3 # Pfam PF07883 Cupin_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ALLE_ECOLI (S)-ureidoglycine aminohydrolase # RefSeq NP_415048 NC_000913.3 # RefSeq WP_000540997 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB93856.1; Type=Frameshift; Positions=222; Evidence={ECO 0000305}; # SIMILARITY Belongs to the UGHY family. {ECO 0000305}. # SUBCELLULAR LOCATION ALLE_ECOLI Cytoplasm {ECO 0000269|PubMed 19935661}. # SUPFAM SSF51182 SSF51182 # TIGRFAMs TIGR03214 ura-cupin # eggNOG COG3257 LUCA # eggNOG ENOG4105S0E Bacteria BLAST swissprot:ALLE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ALLE_ECOLI BioCyc ECOL316407:JW0503-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0503-MONOMER BioCyc EcoCyc:G6284-MONOMER http://biocyc.org/getid?id=EcoCyc:G6284-MONOMER BioCyc MetaCyc:G6284-MONOMER http://biocyc.org/getid?id=MetaCyc:G6284-MONOMER COG COG3257 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3257 DIP DIP-12689N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12689N DOI 10.1021/cb900248n http://dx.doi.org/10.1021/cb900248n DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nchembio.265 http://dx.doi.org/10.1038/nchembio.265 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.5.3.26 http://www.genome.jp/dbget-bin/www_bget?EC:3.5.3.26 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL U89279 http://www.ebi.ac.uk/ena/data/view/U89279 ENZYME 3.5.3.26 http://enzyme.expasy.org/EC/3.5.3.26 EchoBASE EB3387 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3387 EcoGene EG13622 http://www.ecogene.org/geneInfo.php?eg_id=EG13622 EnsemblBacteria AAC73617 http://www.ensemblgenomes.org/id/AAC73617 EnsemblBacteria AAC73617 http://www.ensemblgenomes.org/id/AAC73617 EnsemblBacteria BAE76293 http://www.ensemblgenomes.org/id/BAE76293 EnsemblBacteria BAE76293 http://www.ensemblgenomes.org/id/BAE76293 EnsemblBacteria BAE76293 http://www.ensemblgenomes.org/id/BAE76293 EnsemblBacteria b0515 http://www.ensemblgenomes.org/id/b0515 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_function GO:0071522 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071522 GO_process GO:0006144 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006144 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 2.60.120.10 http://www.cathdb.info/version/latest/superfamily/2.60.120.10 GeneID 945149 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945149 HOGENOM HOG000219622 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219622&db=HOGENOM6 InParanoid P75713 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75713 IntAct P75713 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75713* IntEnz 3.5.3.26 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.3.26 InterPro IPR008579 http://www.ebi.ac.uk/interpro/entry/IPR008579 InterPro IPR011051 http://www.ebi.ac.uk/interpro/entry/IPR011051 InterPro IPR013096 http://www.ebi.ac.uk/interpro/entry/IPR013096 InterPro IPR014710 http://www.ebi.ac.uk/interpro/entry/IPR014710 InterPro IPR017627 http://www.ebi.ac.uk/interpro/entry/IPR017627 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0503 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0503 KEGG_Gene eco:b0515 http://www.genome.jp/dbget-bin/www_bget?eco:b0515 KEGG_Orthology KO:K14977 http://www.genome.jp/dbget-bin/www_bget?KO:K14977 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Reaction rn:R05554 http://www.genome.jp/dbget-bin/www_bget?rn:R05554 OMA LNRDWVE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LNRDWVE PDB 1RC6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1RC6 PDBsum 1RC6 http://www.ebi.ac.uk/pdbsum/1RC6 PSORT swissprot:ALLE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ALLE_ECOLI PSORT-B swissprot:ALLE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ALLE_ECOLI PSORT2 swissprot:ALLE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ALLE_ECOLI Pfam PF05899 http://pfam.xfam.org/family/PF05899 Pfam PF07883 http://pfam.xfam.org/family/PF07883 Phobius swissprot:ALLE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ALLE_ECOLI PhylomeDB P75713 http://phylomedb.org/?seqid=P75713 ProteinModelPortal P75713 http://www.proteinmodelportal.org/query/uniprot/P75713 PubMed 10601204 http://www.ncbi.nlm.nih.gov/pubmed/10601204 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19935661 http://www.ncbi.nlm.nih.gov/pubmed/19935661 PubMed 20038185 http://www.ncbi.nlm.nih.gov/pubmed/20038185 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415048 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415048 RefSeq WP_000540997 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000540997 SMR P75713 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75713 STRING 511145.b0515 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0515&targetmode=cogs STRING COG3257 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3257&targetmode=cogs SUPFAM SSF51182 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51182 TIGRFAMs TIGR03214 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03214 UniProtKB ALLE_ECOLI http://www.uniprot.org/uniprot/ALLE_ECOLI UniProtKB-AC P75713 http://www.uniprot.org/uniprot/P75713 charge swissprot:ALLE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ALLE_ECOLI eggNOG COG3257 http://eggnogapi.embl.de/nog_data/html/tree/COG3257 eggNOG ENOG4105S0E http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105S0E epestfind swissprot:ALLE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ALLE_ECOLI garnier swissprot:ALLE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ALLE_ECOLI helixturnhelix swissprot:ALLE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ALLE_ECOLI hmoment swissprot:ALLE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ALLE_ECOLI iep swissprot:ALLE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ALLE_ECOLI inforesidue swissprot:ALLE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ALLE_ECOLI octanol swissprot:ALLE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ALLE_ECOLI pepcoil swissprot:ALLE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ALLE_ECOLI pepdigest swissprot:ALLE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ALLE_ECOLI pepinfo swissprot:ALLE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ALLE_ECOLI pepnet swissprot:ALLE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ALLE_ECOLI pepstats swissprot:ALLE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ALLE_ECOLI pepwheel swissprot:ALLE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ALLE_ECOLI pepwindow swissprot:ALLE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ALLE_ECOLI sigcleave swissprot:ALLE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ALLE_ECOLI ## Database ID URL or Descriptions # AltName AROD_ECOLI Type I DHQase {ECO 0000255|HAMAP-Rule MF_00214, ECO 0000303|PubMed 13198937} # AltName AROD_ECOLI Type I dehydroquinase {ECO 0000255|HAMAP-Rule MF_00214, ECO 0000303|PubMed 13198937} # BIOPHYSICOCHEMICAL PROPERTIES AROD_ECOLI Kinetic parameters KM=17 uM for 3-dehydroquinate (at pH 7 and 25 degrees Celsius) {ECO 0000269|PubMed 7592767}; KM=18 uM for 3-dehydroquinate (at pH 7 and 25 degrees Celsius) {ECO 0000269|PubMed 2950851}; Note=Kcat is 142 sec(-1) for dehydratase activity with 3- dehydroquinate (at pH 7 and 25 degrees Celsius). {ECO 0000269|PubMed 7592767}; # CATALYTIC ACTIVITY AROD_ECOLI 3-dehydroquinate = 3-dehydroshikimate + H(2)O. {ECO 0000255|HAMAP-Rule MF_00214, ECO 0000269|PubMed 2950851, ECO 0000269|PubMed 7592767}. # CDD cd00502 DHQase_I # ENZYME REGULATION Inhibited by sodium borohydride. {ECO:0000269|PubMed 2950851}. # EcoGene EG10076 aroD # FUNCTION AROD_ECOLI Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids (AroAA). Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate. The reaction involves the formation of an imine intermediate between the keto group of 3-dehydroquinate and the epsylon-amino group of a lys-170 at the active site. {ECO 0000255|HAMAP-Rule MF_00214, ECO 0000269|PubMed 13198937, ECO 0000269|PubMed 2950851, ECO 0000269|PubMed 3541912, ECO 0000269|PubMed 7592767}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003855 3-dehydroquinate dehydratase activity; IDA:UniProtKB. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0050661 NADP binding; IBA:GO_Central. # GO_process GO:0008652 cellular amino acid biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0009073 aromatic amino acid family biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0009423 chorismate biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0046279 3,4-dihydroxybenzoate biosynthetic process; IDA:UniProtKB. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.70 -; 1. # HAMAP MF_00214 AroD # IntAct P05194 6 # InterPro IPR001381 DHquinase_I # InterPro IPR013785 Aldolase_TIM # InterPro IPR018508 3-dehydroquinate_DH_AS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis # MASS SPECTROMETRY Mass=27467; Method=Electrospray; Range=1-252; Evidence={ECO:0000269|PubMed 7592767}; # Organism AROD_ECOLI Escherichia coli (strain K12) # PATHWAY Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. {ECO 0000255|HAMAP-Rule:MF_00214}. # PATRIC 32118692 VBIEscCol129921_1764 # PIR S14750 DWECDQ # PROSITE PS01028 DEHYDROQUINASE_I # Pfam PF01487 DHquinase_I # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AROD_ECOLI 3-dehydroquinate dehydratase {ECO 0000255|HAMAP-Rule MF_00214, ECO 0000303|PubMed 13198937} # RefSeq NP_416208 NC_000913.3 # RefSeq WP_000860201 NZ_LN832404.1 # SIMILARITY Belongs to the type-I 3-dehydroquinase family. {ECO:0000255|HAMAP-Rule MF_00214}. # SUBUNIT AROD_ECOLI Homodimer. {ECO 0000255|HAMAP-Rule MF_00214, ECO 0000269|PubMed 2950851}. # TIGRFAMs TIGR01093 aroD # UniPathway UPA00053 UER00086 # eggNOG COG0710 LUCA # eggNOG ENOG4105FF2 Bacteria BLAST swissprot:AROD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AROD_ECOLI BioCyc ECOL316407:JW1683-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1683-MONOMER BioCyc EcoCyc:AROD-MONOMER http://biocyc.org/getid?id=EcoCyc:AROD-MONOMER BioCyc MetaCyc:AROD-MONOMER http://biocyc.org/getid?id=MetaCyc:AROD-MONOMER COG COG0710 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0710 DOI 10.1016/0006-3002(54)90093-1 http://dx.doi.org/10.1016/0006-3002(54)90093-1 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2380475 http://dx.doi.org/10.1042/bj2380475 DOI 10.1042/bj2390699 http://dx.doi.org/10.1042/bj2390699 DOI 10.1042/bj2750001 http://dx.doi.org/10.1042/bj2750001 DOI 10.1074/jbc.270.43.25827 http://dx.doi.org/10.1074/jbc.270.43.25827 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.1.10 {ECO:0000255|HAMAP-Rule:MF_00214, ECO:0000269|PubMed:2950851, ECO:0000269|PubMed:7592767} http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.10 {ECO:0000255|HAMAP-Rule:MF_00214, ECO:0000269|PubMed:2950851, ECO:0000269|PubMed:7592767} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X04306 http://www.ebi.ac.uk/ena/data/view/X04306 EMBL X59503 http://www.ebi.ac.uk/ena/data/view/X59503 ENZYME 4.2.1.10 {ECO:0000255|HAMAP-Rule:MF_00214, ECO:0000269|PubMed:2950851, ECO:0000269|PubMed:7592767} http://enzyme.expasy.org/EC/4.2.1.10 {ECO:0000255|HAMAP-Rule:MF_00214, ECO:0000269|PubMed:2950851, ECO:0000269|PubMed:7592767} EchoBASE EB0074 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0074 EcoGene EG10076 http://www.ecogene.org/geneInfo.php?eg_id=EG10076 EnsemblBacteria AAC74763 http://www.ensemblgenomes.org/id/AAC74763 EnsemblBacteria AAC74763 http://www.ensemblgenomes.org/id/AAC74763 EnsemblBacteria BAA15448 http://www.ensemblgenomes.org/id/BAA15448 EnsemblBacteria BAA15448 http://www.ensemblgenomes.org/id/BAA15448 EnsemblBacteria BAA15448 http://www.ensemblgenomes.org/id/BAA15448 EnsemblBacteria b1693 http://www.ensemblgenomes.org/id/b1693 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003855 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003855 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0050661 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050661 GO_process GO:0008652 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008652 GO_process GO:0009073 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009073 GO_process GO:0009423 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009423 GO_process GO:0046279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046279 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 946210 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946210 HAMAP MF_00214 http://hamap.expasy.org/unirule/MF_00214 HOGENOM HOG000105514 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000105514&db=HOGENOM6 InParanoid P05194 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P05194 IntAct P05194 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P05194* IntEnz 4.2.1.10 {ECO:0000255|HAMAP-Rule:MF_00214, ECO:0000269|PubMed:2950851, ECO:0000269|PubMed:7592767} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.10 {ECO:0000255|HAMAP-Rule:MF_00214, ECO:0000269|PubMed:2950851, ECO:0000269|PubMed:7592767} InterPro IPR001381 http://www.ebi.ac.uk/interpro/entry/IPR001381 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR018508 http://www.ebi.ac.uk/interpro/entry/IPR018508 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1683 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1683 KEGG_Gene eco:b1693 http://www.genome.jp/dbget-bin/www_bget?eco:b1693 KEGG_Orthology KO:K03785 http://www.genome.jp/dbget-bin/www_bget?KO:K03785 KEGG_Pathway ko00400 http://www.genome.jp/kegg-bin/show_pathway?ko00400 KEGG_Reaction rn:R03084 http://www.genome.jp/dbget-bin/www_bget?rn:R03084 OMA LFTFRSK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LFTFRSK PROSITE PS01028 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01028 PSORT swissprot:AROD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AROD_ECOLI PSORT-B swissprot:AROD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AROD_ECOLI PSORT2 swissprot:AROD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AROD_ECOLI Pfam PF01487 http://pfam.xfam.org/family/PF01487 Phobius swissprot:AROD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AROD_ECOLI PhylomeDB P05194 http://phylomedb.org/?seqid=P05194 ProteinModelPortal P05194 http://www.proteinmodelportal.org/query/uniprot/P05194 PubMed 13198937 http://www.ncbi.nlm.nih.gov/pubmed/13198937 PubMed 1429576 http://www.ncbi.nlm.nih.gov/pubmed/1429576 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1826831 http://www.ncbi.nlm.nih.gov/pubmed/1826831 PubMed 2950851 http://www.ncbi.nlm.nih.gov/pubmed/2950851 PubMed 3541912 http://www.ncbi.nlm.nih.gov/pubmed/3541912 PubMed 7592767 http://www.ncbi.nlm.nih.gov/pubmed/7592767 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416208 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416208 RefSeq WP_000860201 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000860201 SMR P05194 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P05194 STRING 511145.b1693 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1693&targetmode=cogs STRING COG0710 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0710&targetmode=cogs SWISS-2DPAGE P05194 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P05194 TIGRFAMs TIGR01093 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01093 UniProtKB AROD_ECOLI http://www.uniprot.org/uniprot/AROD_ECOLI UniProtKB-AC P05194 http://www.uniprot.org/uniprot/P05194 charge swissprot:AROD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AROD_ECOLI eggNOG COG0710 http://eggnogapi.embl.de/nog_data/html/tree/COG0710 eggNOG ENOG4105FF2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FF2 epestfind swissprot:AROD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AROD_ECOLI garnier swissprot:AROD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AROD_ECOLI helixturnhelix swissprot:AROD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AROD_ECOLI hmoment swissprot:AROD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AROD_ECOLI iep swissprot:AROD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AROD_ECOLI inforesidue swissprot:AROD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AROD_ECOLI octanol swissprot:AROD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AROD_ECOLI pepcoil swissprot:AROD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AROD_ECOLI pepdigest swissprot:AROD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AROD_ECOLI pepinfo swissprot:AROD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AROD_ECOLI pepnet swissprot:AROD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AROD_ECOLI pepstats swissprot:AROD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AROD_ECOLI pepwheel swissprot:AROD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AROD_ECOLI pepwindow swissprot:AROD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AROD_ECOLI sigcleave swissprot:AROD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AROD_ECOLI ## Database ID URL or Descriptions # BioGrid 4260655 17 # EcoGene EG13702 ycbJ # InterPro IPR002575 Aminoglycoside_PTrfase # InterPro IPR011009 Kinase-like_dom # Organism YCBJ_ECOLI Escherichia coli (strain K12) # PATRIC 32117051 VBIEscCol129921_0950 # PIR F64831 F64831 # Pfam PF01636 APH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCBJ_ECOLI Uncharacterized protein YcbJ # RefSeq NP_415439 NC_000913.3 # RefSeq WP_000436922 NZ_LN832404.1 # SUPFAM SSF56112 SSF56112 # eggNOG ENOG4107VR7 Bacteria # eggNOG ENOG410XRNM LUCA BLAST swissprot:YCBJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCBJ_ECOLI BioCyc ECOL316407:JW0902-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0902-MONOMER BioCyc EcoCyc:G6473-MONOMER http://biocyc.org/getid?id=EcoCyc:G6473-MONOMER DIP DIP-48267N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48267N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J02614 http://www.ebi.ac.uk/ena/data/view/J02614 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3466 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3466 EcoGene EG13702 http://www.ecogene.org/geneInfo.php?eg_id=EG13702 EnsemblBacteria AAC74005 http://www.ensemblgenomes.org/id/AAC74005 EnsemblBacteria AAC74005 http://www.ensemblgenomes.org/id/AAC74005 EnsemblBacteria BAA35665 http://www.ensemblgenomes.org/id/BAA35665 EnsemblBacteria BAA35665 http://www.ensemblgenomes.org/id/BAA35665 EnsemblBacteria BAA35665 http://www.ensemblgenomes.org/id/BAA35665 EnsemblBacteria b0919 http://www.ensemblgenomes.org/id/b0919 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945545 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945545 HOGENOM HOG000118773 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118773&db=HOGENOM6 IntAct P0AB03 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AB03* InterPro IPR002575 http://www.ebi.ac.uk/interpro/entry/IPR002575 InterPro IPR011009 http://www.ebi.ac.uk/interpro/entry/IPR011009 KEGG_Gene ecj:JW0902 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0902 KEGG_Gene eco:b0919 http://www.genome.jp/dbget-bin/www_bget?eco:b0919 OMA WYQQRVE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WYQQRVE PSORT swissprot:YCBJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCBJ_ECOLI PSORT-B swissprot:YCBJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCBJ_ECOLI PSORT2 swissprot:YCBJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCBJ_ECOLI Pfam PF01636 http://pfam.xfam.org/family/PF01636 Phobius swissprot:YCBJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCBJ_ECOLI ProteinModelPortal P0AB03 http://www.proteinmodelportal.org/query/uniprot/P0AB03 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3023327 http://www.ncbi.nlm.nih.gov/pubmed/3023327 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415439 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415439 RefSeq WP_000436922 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000436922 SMR P0AB03 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AB03 STRING 511145.b0919 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0919&targetmode=cogs SUPFAM SSF56112 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56112 UniProtKB YCBJ_ECOLI http://www.uniprot.org/uniprot/YCBJ_ECOLI UniProtKB-AC P0AB03 http://www.uniprot.org/uniprot/P0AB03 charge swissprot:YCBJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCBJ_ECOLI eggNOG ENOG4107VR7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107VR7 eggNOG ENOG410XRNM http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRNM epestfind swissprot:YCBJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCBJ_ECOLI garnier swissprot:YCBJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCBJ_ECOLI helixturnhelix swissprot:YCBJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCBJ_ECOLI hmoment swissprot:YCBJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCBJ_ECOLI iep swissprot:YCBJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCBJ_ECOLI inforesidue swissprot:YCBJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCBJ_ECOLI octanol swissprot:YCBJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCBJ_ECOLI pepcoil swissprot:YCBJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCBJ_ECOLI pepdigest swissprot:YCBJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCBJ_ECOLI pepinfo swissprot:YCBJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCBJ_ECOLI pepnet swissprot:YCBJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCBJ_ECOLI pepstats swissprot:YCBJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCBJ_ECOLI pepwheel swissprot:YCBJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCBJ_ECOLI pepwindow swissprot:YCBJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCBJ_ECOLI sigcleave swissprot:YCBJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCBJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4263014 16 # EcoGene EG13746 paaX # FUNCTION PAAX_ECOLI Negative regulator of the paaZ and paaABCDEFGHIJK catabolic operons. Binds the consensus sequence 5'- WWTRTGATTCGYGWT-3'. Binding of PaaX is specifically inhibited by phenylacetyl-coenzyme A (PA-CoA). {ECO 0000269|PubMed 10766858, ECO 0000269|PubMed 9748275}. # GO_function GO:0000984 bacterial-type RNA polymerase regulatory region sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0010124 phenylacetate catabolic process; IMP:UniProtKB. # GO_process GO:2000143 negative regulation of DNA-templated transcription, initiation; IMP:EcoCyc. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # INTERACTION PAAX_ECOLI P0AE82 cpxA; NbExp=3; IntAct=EBI-544692, EBI-9141330; P41443 gspH; NbExp=2; IntAct=EBI-544692, EBI-1129978; # IntAct P76086 21 # InterPro IPR011965 PaaX_trns_reg # InterPro IPR012906 PaaX-like_N # InterPro IPR013225 PaaX_C # KEGG_Brite ko03000 Transcription factors # Organism PAAX_ECOLI Escherichia coli (strain K12) # PATHWAY PAAX_ECOLI Aromatic compound metabolism; phenylacetate degradation. # PATRIC 32118084 VBIEscCol129921_1462 # PIR B64891 B64891 # PIRSF PIRSF020623 PaaX # Pfam PF07848 PaaX # Pfam PF08223 PaaX_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PAAX_ECOLI Transcriptional repressor PaaX # RefSeq NP_415917 NC_000913.3 # RefSeq WP_000039887 NZ_LN832404.1 # SIMILARITY Belongs to the PaaX family. {ECO 0000305}. # TIGRFAMs TIGR02277 PaaX_trns_reg # eggNOG COG3327 LUCA # eggNOG ENOG4105V9J Bacteria BLAST swissprot:PAAX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PAAX_ECOLI BioCyc ECOL316407:JW1394-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1394-MONOMER BioCyc EcoCyc:G6720-MONOMER http://biocyc.org/getid?id=EcoCyc:G6720-MONOMER COG COG3327 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3327 DIP DIP-10431N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10431N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.273.40.25974 http://dx.doi.org/10.1074/jbc.273.40.25974 DOI 10.1074/jbc.275.16.12214 http://dx.doi.org/10.1074/jbc.275.16.12214 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X97452 http://www.ebi.ac.uk/ena/data/view/X97452 EchoBASE EB3509 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3509 EcoGene EG13746 http://www.ecogene.org/geneInfo.php?eg_id=EG13746 EnsemblBacteria AAC74481 http://www.ensemblgenomes.org/id/AAC74481 EnsemblBacteria AAC74481 http://www.ensemblgenomes.org/id/AAC74481 EnsemblBacteria BAE76429 http://www.ensemblgenomes.org/id/BAE76429 EnsemblBacteria BAE76429 http://www.ensemblgenomes.org/id/BAE76429 EnsemblBacteria BAE76429 http://www.ensemblgenomes.org/id/BAE76429 EnsemblBacteria b1399 http://www.ensemblgenomes.org/id/b1399 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000984 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000984 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0010124 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010124 GO_process GO:2000143 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000143 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 945966 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945966 HOGENOM HOG000147151 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000147151&db=HOGENOM6 InParanoid P76086 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76086 IntAct P76086 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76086* InterPro IPR011965 http://www.ebi.ac.uk/interpro/entry/IPR011965 InterPro IPR012906 http://www.ebi.ac.uk/interpro/entry/IPR012906 InterPro IPR013225 http://www.ebi.ac.uk/interpro/entry/IPR013225 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW1394 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1394 KEGG_Gene eco:b1399 http://www.genome.jp/dbget-bin/www_bget?eco:b1399 KEGG_Orthology KO:K02616 http://www.genome.jp/dbget-bin/www_bget?KO:K02616 OMA LLIHEYR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LLIHEYR PSORT swissprot:PAAX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PAAX_ECOLI PSORT-B swissprot:PAAX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PAAX_ECOLI PSORT2 swissprot:PAAX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PAAX_ECOLI Pfam PF07848 http://pfam.xfam.org/family/PF07848 Pfam PF08223 http://pfam.xfam.org/family/PF08223 Phobius swissprot:PAAX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PAAX_ECOLI PhylomeDB P76086 http://phylomedb.org/?seqid=P76086 ProteinModelPortal P76086 http://www.proteinmodelportal.org/query/uniprot/P76086 PubMed 10766858 http://www.ncbi.nlm.nih.gov/pubmed/10766858 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9748275 http://www.ncbi.nlm.nih.gov/pubmed/9748275 RefSeq NP_415917 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415917 RefSeq WP_000039887 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000039887 SMR P76086 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76086 STRING 511145.b1399 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1399&targetmode=cogs STRING COG3327 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3327&targetmode=cogs TIGRFAMs TIGR02277 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02277 UniProtKB PAAX_ECOLI http://www.uniprot.org/uniprot/PAAX_ECOLI UniProtKB-AC P76086 http://www.uniprot.org/uniprot/P76086 charge swissprot:PAAX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PAAX_ECOLI eggNOG COG3327 http://eggnogapi.embl.de/nog_data/html/tree/COG3327 eggNOG ENOG4105V9J http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105V9J epestfind swissprot:PAAX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PAAX_ECOLI garnier swissprot:PAAX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PAAX_ECOLI helixturnhelix swissprot:PAAX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PAAX_ECOLI hmoment swissprot:PAAX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PAAX_ECOLI iep swissprot:PAAX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PAAX_ECOLI inforesidue swissprot:PAAX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PAAX_ECOLI octanol swissprot:PAAX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PAAX_ECOLI pepcoil swissprot:PAAX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PAAX_ECOLI pepdigest swissprot:PAAX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PAAX_ECOLI pepinfo swissprot:PAAX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PAAX_ECOLI pepnet swissprot:PAAX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PAAX_ECOLI pepstats swissprot:PAAX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PAAX_ECOLI pepwheel swissprot:PAAX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PAAX_ECOLI pepwindow swissprot:PAAX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PAAX_ECOLI sigcleave swissprot:PAAX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PAAX_ECOLI ## Database ID URL or Descriptions # BioGrid 4259232 9 # BioGrid 4259233 16 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # CDD cd06170 LuxR_C_like # EcoGene EG13041 ygeK # GO_component GO:0005622 intracellular; IEA:GOC. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0000160 phosphorelay signal transduction system; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_component GO:0005622 intracellular # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # InterPro IPR000792 Tscrpt_reg_LuxR_C # InterPro IPR001789 Sig_transdc_resp-reg_receiver # InterPro IPR011006 CheY-like_superfamily # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR016032 Sig_transdc_resp-reg_C-effctor # Organism YGEK_ECOLI Escherichia coli (strain K12) # PIR A65069 A65069 # PIR H65068 H65068 # PRINTS PR00038 HTHLUXR # PROSITE PS00622 HTH_LUXR_1 # PROSITE PS50043 HTH_LUXR_2 # PROSITE PS50110 RESPONSE_REGULATORY # Pfam PF00072 Response_reg # Pfam PF00196 GerE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGEK_ECOLI Putative uncharacterized response regulatory protein YgeK # SEQUENCE CAUTION YGEK_ECOLI Sequence=AAA83037.1; Type=Erroneous termination; Positions=52; Note=Translated as Gln.; Evidence={ECO 0000305}; Sequence=AAA83038.1; Type=Erroneous termination; Positions=52; Note=Translated as Gln.; Evidence={ECO 0000305}; Sequence=BAE76923.1; Type=Erroneous termination; Positions=52; Note=Translated as Gln.; Evidence={ECO 0000305}; Sequence=BAE76924.1; Type=Erroneous termination; Positions=52; Note=Translated as Gln.; Evidence={ECO 0000305}; Sequence=U00096; Type=Erroneous termination; Positions=52; Note=Translated as Gln.; Evidence={ECO 0000305}; # SIMILARITY Contains 1 HTH luxR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00411}. # SIMILARITY Contains 1 response regulatory domain. {ECO:0000255|PROSITE-ProRule PRU00169}. # SMART SM00421 HTH_LUXR # SUPFAM SSF46894 SSF46894 # SUPFAM SSF52172 SSF52172 BLAST swissprot:YGEK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGEK_ECOLI BioCyc ECOL316407:JW2824-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2824-MONOMER BioCyc ECOL316407:JW5458-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5458-MONOMER BioCyc EcoCyc:G7475-MONOMER http://biocyc.org/getid?id=EcoCyc:G7475-MONOMER BioCyc EcoCyc:G7476-MONOMER http://biocyc.org/getid?id=EcoCyc:G7476-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 EchoBASE EB2856 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2856 EcoGene EG13041 http://www.ecogene.org/geneInfo.php?eg_id=EG13041 EnsemblBacteria BAE76923 http://www.ensemblgenomes.org/id/BAE76923 EnsemblBacteria BAE76923 http://www.ensemblgenomes.org/id/BAE76923 EnsemblBacteria BAE76923 http://www.ensemblgenomes.org/id/BAE76923 EnsemblBacteria BAE76924 http://www.ensemblgenomes.org/id/BAE76924 EnsemblBacteria BAE76924 http://www.ensemblgenomes.org/id/BAE76924 EnsemblBacteria BAE76924 http://www.ensemblgenomes.org/id/BAE76924 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 HOGENOM HOG000034813 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000034813&db=HOGENOM6 InParanoid Q46791 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46791 InterPro IPR000792 http://www.ebi.ac.uk/interpro/entry/IPR000792 InterPro IPR001789 http://www.ebi.ac.uk/interpro/entry/IPR001789 InterPro IPR011006 http://www.ebi.ac.uk/interpro/entry/IPR011006 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR016032 http://www.ebi.ac.uk/interpro/entry/IPR016032 KEGG_Gene ecj:JW2824 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2824 KEGG_Gene ecj:JW5458 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5458 OMA TAXIFIL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TAXIFIL PRINTS PR00038 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00038 PROSITE PS00622 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00622 PROSITE PS50043 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50043 PROSITE PS50110 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50110 PSORT swissprot:YGEK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGEK_ECOLI PSORT-B swissprot:YGEK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGEK_ECOLI PSORT2 swissprot:YGEK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGEK_ECOLI Pfam PF00072 http://pfam.xfam.org/family/PF00072 Pfam PF00196 http://pfam.xfam.org/family/PF00196 Phobius swissprot:YGEK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGEK_ECOLI PhylomeDB Q46791 http://phylomedb.org/?seqid=Q46791 ProteinModelPortal Q46791 http://www.proteinmodelportal.org/query/uniprot/Q46791 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SMART SM00421 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00421 SMR Q46791 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46791 STRING 316407.85675670 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85675670&targetmode=cogs SUPFAM SSF46894 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46894 SUPFAM SSF52172 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52172 UniProtKB YGEK_ECOLI http://www.uniprot.org/uniprot/YGEK_ECOLI UniProtKB-AC Q46791 http://www.uniprot.org/uniprot/Q46791 charge swissprot:YGEK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGEK_ECOLI epestfind swissprot:YGEK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGEK_ECOLI garnier swissprot:YGEK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGEK_ECOLI helixturnhelix swissprot:YGEK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGEK_ECOLI hmoment swissprot:YGEK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGEK_ECOLI iep swissprot:YGEK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGEK_ECOLI inforesidue swissprot:YGEK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGEK_ECOLI octanol swissprot:YGEK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGEK_ECOLI pepcoil swissprot:YGEK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGEK_ECOLI pepdigest swissprot:YGEK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGEK_ECOLI pepinfo swissprot:YGEK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGEK_ECOLI pepnet swissprot:YGEK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGEK_ECOLI pepstats swissprot:YGEK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGEK_ECOLI pepwheel swissprot:YGEK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGEK_ECOLI pepwindow swissprot:YGEK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGEK_ECOLI sigcleave swissprot:YGEK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGEK_ECOLI ## Database ID URL or Descriptions # AltName FES_ECOLI Ferric enterobactin esterase # BioGrid 4259896 327 # ESTHER ecoli-fes A85-IroE-IroD-Fes-Yiel # EcoGene EG10299 fes # FUNCTION FES_ECOLI Upon internalization, ferric enterobactin is processed via an exquisitely specific pathway that is dependent on FES activity, making iron available for metabolic use. # GO_component GO:0005576 extracellular region; IBA:GO_Central. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0005506 iron ion binding; IEA:InterPro. # GO_function GO:0008849 enterochelin esterase activity; IDA:EcoliWiki. # GO_process GO:0006826 iron ion transport; IEA:InterPro. # GO_process GO:0046214 enterobactin catabolic process; IMP:EcoCyc. # GO_process GO:0055072 iron ion homeostasis; IEA:UniProtKB-KW. # GOslim_component GO:0005576 extracellular region # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0019748 secondary metabolic process # GOslim_process GO:0042592 homeostatic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 2.60.40.10 -; 1. # Gene3D 3.40.50.1820 -; 1. # IntAct P13039 5 # InterPro IPR000801 Esterase_put # InterPro IPR013783 Ig-like_fold # InterPro IPR014756 Ig_E-set # InterPro IPR021764 Enterochelin_esterase_N # InterPro IPR029058 AB_hydrolase # Organism FES_ECOLI Escherichia coli (strain K12) # PATRIC 32116342 VBIEscCol129921_0611 # PIR A31958 BVECES # Pfam PF00756 Esterase # Pfam PF11806 DUF3327 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FES_ECOLI Enterochelin esterase # RefSeq NP_415117 NC_000913.3 # RefSeq WP_000125843 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA23757.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA35226.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the Fes family. {ECO 0000305}. # SUBCELLULAR LOCATION FES_ECOLI Cytoplasm. # SUPFAM SSF53474 SSF53474 # SUPFAM SSF81296 SSF81296 # eggNOG COG2382 LUCA # eggNOG ENOG4105E93 Bacteria BLAST swissprot:FES_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FES_ECOLI BioCyc ECOL316407:JW0576-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0576-MONOMER BioCyc EcoCyc:EG10299-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10299-MONOMER BioCyc MetaCyc:EG10299-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10299-MONOMER COG COG2382 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2382 DIP DIP-9598N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9598N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/mcp.M113.029165 http://dx.doi.org/10.1074/mcp.M113.029165 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J04216 http://www.ebi.ac.uk/ena/data/view/J04216 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB0295 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0295 EcoGene EG10299 http://www.ecogene.org/geneInfo.php?eg_id=EG10299 EnsemblBacteria AAC73686 http://www.ensemblgenomes.org/id/AAC73686 EnsemblBacteria AAC73686 http://www.ensemblgenomes.org/id/AAC73686 EnsemblBacteria BAA35226 http://www.ensemblgenomes.org/id/BAA35226 EnsemblBacteria BAA35226 http://www.ensemblgenomes.org/id/BAA35226 EnsemblBacteria BAA35226 http://www.ensemblgenomes.org/id/BAA35226 EnsemblBacteria b0585 http://www.ensemblgenomes.org/id/b0585 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005576 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576 GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0008849 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008849 GO_process GO:0006826 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006826 GO_process GO:0046214 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046214 GO_process GO:0055072 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055072 GOslim_component GO:0005576 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0019748 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019748 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 2.60.40.10 http://www.cathdb.info/version/latest/superfamily/2.60.40.10 Gene3D 3.40.50.1820 http://www.cathdb.info/version/latest/superfamily/3.40.50.1820 GeneID 945181 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945181 HOGENOM HOG000117845 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117845&db=HOGENOM6 InParanoid P13039 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P13039 IntAct P13039 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P13039* InterPro IPR000801 http://www.ebi.ac.uk/interpro/entry/IPR000801 InterPro IPR013783 http://www.ebi.ac.uk/interpro/entry/IPR013783 InterPro IPR014756 http://www.ebi.ac.uk/interpro/entry/IPR014756 InterPro IPR021764 http://www.ebi.ac.uk/interpro/entry/IPR021764 InterPro IPR029058 http://www.ebi.ac.uk/interpro/entry/IPR029058 KEGG_Gene ecj:JW0576 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0576 KEGG_Gene eco:b0585 http://www.genome.jp/dbget-bin/www_bget?eco:b0585 KEGG_Orthology KO:K07214 http://www.genome.jp/dbget-bin/www_bget?KO:K07214 PSORT swissprot:FES_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FES_ECOLI PSORT-B swissprot:FES_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FES_ECOLI PSORT2 swissprot:FES_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FES_ECOLI Pfam PF00756 http://pfam.xfam.org/family/PF00756 Pfam PF11806 http://pfam.xfam.org/family/PF11806 Phobius swissprot:FES_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FES_ECOLI ProteinModelPortal P13039 http://www.proteinmodelportal.org/query/uniprot/P13039 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 23908556 http://www.ncbi.nlm.nih.gov/pubmed/23908556 PubMed 2974033 http://www.ncbi.nlm.nih.gov/pubmed/2974033 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415117 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415117 RefSeq WP_000125843 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000125843 SMR P13039 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P13039 STRING 511145.b0585 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0585&targetmode=cogs STRING COG2382 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2382&targetmode=cogs SUPFAM SSF53474 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53474 SUPFAM SSF81296 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81296 UniProtKB FES_ECOLI http://www.uniprot.org/uniprot/FES_ECOLI UniProtKB-AC P13039 http://www.uniprot.org/uniprot/P13039 charge swissprot:FES_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FES_ECOLI eggNOG COG2382 http://eggnogapi.embl.de/nog_data/html/tree/COG2382 eggNOG ENOG4105E93 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E93 epestfind swissprot:FES_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FES_ECOLI garnier swissprot:FES_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FES_ECOLI helixturnhelix swissprot:FES_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FES_ECOLI hmoment swissprot:FES_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FES_ECOLI iep swissprot:FES_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FES_ECOLI inforesidue swissprot:FES_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FES_ECOLI octanol swissprot:FES_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FES_ECOLI pepcoil swissprot:FES_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FES_ECOLI pepdigest swissprot:FES_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FES_ECOLI pepinfo swissprot:FES_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FES_ECOLI pepnet swissprot:FES_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FES_ECOLI pepstats swissprot:FES_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FES_ECOLI pepwheel swissprot:FES_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FES_ECOLI pepwindow swissprot:FES_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FES_ECOLI sigcleave swissprot:FES_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FES_ECOLI ## Database ID URL or Descriptions # EcoGene EG14490 yrbN # INDUCTION In exponential phase (at protein level). {ECO:0000269|PubMed 19121005}. # Organism YRBN_ECOLI Escherichia coli (strain K12) # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YRBN_ECOLI Uncharacterized protein YrbN # RefSeq YP_002791258 NC_000913.3 BLAST swissprot:YRBN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YRBN_ECOLI BioCyc EcoCyc:MONOMER0-2878 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2878 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2008.06495.x http://dx.doi.org/10.1111/j.1365-2958.2008.06495.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14490 http://www.ecogene.org/geneInfo.php?eg_id=EG14490 EnsemblBacteria ACO60010 http://www.ensemblgenomes.org/id/ACO60010 EnsemblBacteria ACO60010 http://www.ensemblgenomes.org/id/ACO60010 EnsemblBacteria b4685 http://www.ensemblgenomes.org/id/b4685 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 7751619 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7751619 KEGG_Gene eco:b4685 http://www.genome.jp/dbget-bin/www_bget?eco:b4685 PSORT swissprot:YRBN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YRBN_ECOLI PSORT-B swissprot:YRBN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YRBN_ECOLI PSORT2 swissprot:YRBN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YRBN_ECOLI Phobius swissprot:YRBN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YRBN_ECOLI PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19121005 http://www.ncbi.nlm.nih.gov/pubmed/19121005 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq YP_002791258 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_002791258 STRING 511145.b4685 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4685&targetmode=cogs UniProtKB YRBN_ECOLI http://www.uniprot.org/uniprot/YRBN_ECOLI UniProtKB-AC C1P618 http://www.uniprot.org/uniprot/C1P618 charge swissprot:YRBN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YRBN_ECOLI epestfind swissprot:YRBN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YRBN_ECOLI garnier swissprot:YRBN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YRBN_ECOLI helixturnhelix swissprot:YRBN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YRBN_ECOLI hmoment swissprot:YRBN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YRBN_ECOLI iep swissprot:YRBN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YRBN_ECOLI inforesidue swissprot:YRBN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YRBN_ECOLI octanol swissprot:YRBN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YRBN_ECOLI pepcoil swissprot:YRBN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YRBN_ECOLI pepdigest swissprot:YRBN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YRBN_ECOLI pepinfo swissprot:YRBN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YRBN_ECOLI pepnet swissprot:YRBN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YRBN_ECOLI pepstats swissprot:YRBN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YRBN_ECOLI pepwheel swissprot:YRBN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YRBN_ECOLI pepwindow swissprot:YRBN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YRBN_ECOLI sigcleave swissprot:YRBN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YRBN_ECOLI ## Database ID URL or Descriptions # AltName HTGA_ECOLI Heat shock protein HtpY # CAUTION Could be the product of a pseudogene. This gene is encoded entirely within the yaaW gene on the opposite strand; disruptions of one gene are also usually disruptions in the other. {ECO 0000305}. # CAUTION It is uncertain whether Met-1 or Met-36 is the initiator. {ECO 0000305}. # FUNCTION HTGA_ECOLI Has been hypothesized to be implicated in high- temperature growth of E.coli. There are doubts as to whether this is a protein-coding gene however. HtgA may regulate either transcription of the rpoH gene or the activity of its gene product sigma-32. # INDUCTION HTGA_ECOLI Controversial; by high shock at 42 degrees Celsius (PubMed 8478327), later shown not to be induced by sigma-32 (rpoH) (PubMed 16818608). {ECO 0000269|PubMed 16818608, ECO 0000269|PubMed 8400364, ECO 0000269|PubMed 8478327}. # Organism HTGA_ECOLI Escherichia coli (strain K12) # PIR A40623 A40623 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HTGA_ECOLI Putative uncharacterized protein HtgA # SEQUENCE CAUTION Sequence=AAA23993.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA47932.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; BLAST swissprot:HTGA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HTGA_ECOLI BioCyc ECOL316407:JW5001-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5001-MONOMER BioCyc EcoCyc:EG11509-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11509-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1101/gad.1428206 http://dx.doi.org/10.1101/gad.1428206 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1186/1471-2148-8-31 http://dx.doi.org/10.1186/1471-2148-8-31 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L03720 http://www.ebi.ac.uk/ena/data/view/L03720 EMBL L03720 http://www.ebi.ac.uk/ena/data/view/L03720 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X67700 http://www.ebi.ac.uk/ena/data/view/X67700 EchoBASE EB4305 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4305 EnsemblBacteria BAE76028 http://www.ensemblgenomes.org/id/BAE76028 EnsemblBacteria BAE76028 http://www.ensemblgenomes.org/id/BAE76028 EnsemblBacteria BAE76028 http://www.ensemblgenomes.org/id/BAE76028 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv KEGG_Gene ecj:JW5001 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5001 OMA SSLQCWR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SSLQCWR PSORT swissprot:HTGA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HTGA_ECOLI PSORT-B swissprot:HTGA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HTGA_ECOLI PSORT2 swissprot:HTGA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HTGA_ECOLI Phobius swissprot:HTGA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HTGA_ECOLI ProteinModelPortal P28697 http://www.proteinmodelportal.org/query/uniprot/P28697 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16818608 http://www.ncbi.nlm.nih.gov/pubmed/16818608 PubMed 18226237 http://www.ncbi.nlm.nih.gov/pubmed/18226237 PubMed 8400364 http://www.ncbi.nlm.nih.gov/pubmed/8400364 PubMed 8478327 http://www.ncbi.nlm.nih.gov/pubmed/8478327 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 UniProtKB HTGA_ECOLI http://www.uniprot.org/uniprot/HTGA_ECOLI UniProtKB-AC P28697 http://www.uniprot.org/uniprot/P28697 charge swissprot:HTGA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HTGA_ECOLI epestfind swissprot:HTGA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HTGA_ECOLI garnier swissprot:HTGA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HTGA_ECOLI helixturnhelix swissprot:HTGA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HTGA_ECOLI hmoment swissprot:HTGA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HTGA_ECOLI iep swissprot:HTGA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HTGA_ECOLI inforesidue swissprot:HTGA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HTGA_ECOLI octanol swissprot:HTGA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HTGA_ECOLI pepcoil swissprot:HTGA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HTGA_ECOLI pepdigest swissprot:HTGA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HTGA_ECOLI pepinfo swissprot:HTGA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HTGA_ECOLI pepnet swissprot:HTGA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HTGA_ECOLI pepstats swissprot:HTGA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HTGA_ECOLI pepwheel swissprot:HTGA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HTGA_ECOLI pepwindow swissprot:HTGA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HTGA_ECOLI sigcleave swissprot:HTGA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HTGA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259287 6 # EcoGene EG11515 yhcA # FUNCTION YHCA_ECOLI Could be required for the biogenesis of a putative fimbria. {ECO 0000250}. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IEA:InterPro. # GO_process GO:0071555 cell wall organization; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 2.60.40.1070 -; 1. # Gene3D 2.60.40.360 -; 1. # IntAct P28722 14 # InterPro IPR008962 PapD-like # InterPro IPR016147 Pili_assmbl_chaperone_N # InterPro IPR016148 Pili_assmbl_chaperone_C # Organism YHCA_ECOLI Escherichia coli (strain K12) # PATRIC 32121852 VBIEscCol129921_3310 # PIR A65113 A65113 # Pfam PF00345 PapD_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHCA_ECOLI Uncharacterized fimbrial chaperone YhcA # RefSeq NP_417682 NC_000913.3 # RefSeq WP_001311157 NZ_LN832404.1 # SIMILARITY Belongs to the periplasmic pilus chaperone family. {ECO 0000305}. # SIMILARITY Contains 1 Ig-like (immunoglobulin-like) domain. {ECO 0000305}. # SUBCELLULAR LOCATION YHCA_ECOLI Periplasm {ECO 0000250}. # SUPFAM SSF49354 SSF49354 # SUPFAM SSF49584 SSF49584 # eggNOG ENOG4108S1B Bacteria # eggNOG ENOG4111FTJ LUCA BLAST swissprot:YHCA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHCA_ECOLI BioCyc ECOL316407:JW3182-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3182-MONOMER BioCyc EcoCyc:EG11515-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11515-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1992.tb01450.x http://dx.doi.org/10.1111/j.1365-2958.1992.tb01450.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M74162 http://www.ebi.ac.uk/ena/data/view/M74162 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB1477 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1477 EcoGene EG11515 http://www.ecogene.org/geneInfo.php?eg_id=EG11515 EnsemblBacteria AAC76247 http://www.ensemblgenomes.org/id/AAC76247 EnsemblBacteria AAC76247 http://www.ensemblgenomes.org/id/AAC76247 EnsemblBacteria BAE77259 http://www.ensemblgenomes.org/id/BAE77259 EnsemblBacteria BAE77259 http://www.ensemblgenomes.org/id/BAE77259 EnsemblBacteria BAE77259 http://www.ensemblgenomes.org/id/BAE77259 EnsemblBacteria b3215 http://www.ensemblgenomes.org/id/b3215 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 2.60.40.1070 http://www.cathdb.info/version/latest/superfamily/2.60.40.1070 Gene3D 2.60.40.360 http://www.cathdb.info/version/latest/superfamily/2.60.40.360 GeneID 947741 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947741 HOGENOM HOG000260652 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260652&db=HOGENOM6 IntAct P28722 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P28722* InterPro IPR008962 http://www.ebi.ac.uk/interpro/entry/IPR008962 InterPro IPR016147 http://www.ebi.ac.uk/interpro/entry/IPR016147 InterPro IPR016148 http://www.ebi.ac.uk/interpro/entry/IPR016148 KEGG_Gene ecj:JW3182 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3182 KEGG_Gene eco:b3215 http://www.genome.jp/dbget-bin/www_bget?eco:b3215 OMA LPHAWIL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LPHAWIL PSORT swissprot:YHCA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHCA_ECOLI PSORT-B swissprot:YHCA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHCA_ECOLI PSORT2 swissprot:YHCA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHCA_ECOLI Pfam PF00345 http://pfam.xfam.org/family/PF00345 Phobius swissprot:YHCA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHCA_ECOLI PhylomeDB P28722 http://phylomedb.org/?seqid=P28722 ProteinModelPortal P28722 http://www.proteinmodelportal.org/query/uniprot/P28722 PubMed 1447980 http://www.ncbi.nlm.nih.gov/pubmed/1447980 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417682 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417682 RefSeq WP_001311157 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001311157 SMR P28722 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P28722 STRING 511145.b3215 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3215&targetmode=cogs SUPFAM SSF49354 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49354 SUPFAM SSF49584 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49584 UniProtKB YHCA_ECOLI http://www.uniprot.org/uniprot/YHCA_ECOLI UniProtKB-AC P28722 http://www.uniprot.org/uniprot/P28722 charge swissprot:YHCA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHCA_ECOLI eggNOG ENOG4108S1B http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108S1B eggNOG ENOG4111FTJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111FTJ epestfind swissprot:YHCA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHCA_ECOLI garnier swissprot:YHCA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHCA_ECOLI helixturnhelix swissprot:YHCA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHCA_ECOLI hmoment swissprot:YHCA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHCA_ECOLI iep swissprot:YHCA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHCA_ECOLI inforesidue swissprot:YHCA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHCA_ECOLI octanol swissprot:YHCA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHCA_ECOLI pepcoil swissprot:YHCA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHCA_ECOLI pepdigest swissprot:YHCA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHCA_ECOLI pepinfo swissprot:YHCA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHCA_ECOLI pepnet swissprot:YHCA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHCA_ECOLI pepstats swissprot:YHCA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHCA_ECOLI pepwheel swissprot:YHCA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHCA_ECOLI pepwindow swissprot:YHCA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHCA_ECOLI sigcleave swissprot:YHCA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHCA_ECOLI ## Database ID URL or Descriptions # AltName GSPL_ECOLI Putative general secretion pathway protein L # BioGrid 4263437 79 # EcoGene EG12895 gspL # FUNCTION GSPL_ECOLI Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. {ECO 0000305}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0009276 Gram-negative-bacterium-type cell wall; IEA:InterPro. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0008565 protein transporter activity; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005618 cell wall # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0008565 protein transporter activity # INDUCTION Silenced by the DNA-binding protein H-NS under standard growth conditions. {ECO:0000269|PubMed 11118204}. # InterPro IPR007812 T2SS_protein-L # InterPro IPR024230 GspL_cyto_dom # InterPro IPR025691 GspL_pp_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02044 M00331 Type II general secretion system # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko03070 Bacterial secretion system # MISCELLANEOUS GSPL_ECOLI Part of a cryptic operon that encodes proteins involved in type II secretion machinery in other organisms, but is not expressed in strain K12. # Organism GSPL_ECOLI Escherichia coli (strain K12) # PATRIC 32122098 VBIEscCol129921_3426 # PIR H65126 H65126 # PIRSF PIRSF015761 Protein_L # Pfam PF05134 T2SSL # Pfam PF12693 GspL_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GSPL_ECOLI Putative type II secretion system protein L # RefSeq NP_417792 NC_000913.3 # RefSeq WP_001115238 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA58130.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the GSP L family. {ECO 0000305}. # SUBCELLULAR LOCATION GSPL_ECOLI Cell inner membrane {ECO 0000305}; Single- pass membrane protein {ECO 0000305}. # TIGRFAMs TIGR01709 typeII_sec_gspL # eggNOG COG3297 LUCA # eggNOG ENOG41063JA Bacteria BLAST swissprot:GSPL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GSPL_ECOLI BioCyc ECOL316407:JW5705-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5705-MONOMER BioCyc EcoCyc:G7711-MONOMER http://biocyc.org/getid?id=EcoCyc:G7711-MONOMER BioCyc MetaCyc:G7711-MONOMER http://biocyc.org/getid?id=MetaCyc:G7711-MONOMER COG COG3297 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3297 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/emboj/19.24.6697 http://dx.doi.org/10.1093/emboj/19.24.6697 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2732 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2732 EcoGene EG12895 http://www.ecogene.org/geneInfo.php?eg_id=EG12895 EnsemblBacteria AAC76358 http://www.ensemblgenomes.org/id/AAC76358 EnsemblBacteria AAC76358 http://www.ensemblgenomes.org/id/AAC76358 EnsemblBacteria BAE77958 http://www.ensemblgenomes.org/id/BAE77958 EnsemblBacteria BAE77958 http://www.ensemblgenomes.org/id/BAE77958 EnsemblBacteria BAE77958 http://www.ensemblgenomes.org/id/BAE77958 EnsemblBacteria b3333 http://www.ensemblgenomes.org/id/b3333 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0009276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009276 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005618 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GeneID 947842 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947842 HOGENOM HOG000125386 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125386&db=HOGENOM6 InterPro IPR007812 http://www.ebi.ac.uk/interpro/entry/IPR007812 InterPro IPR024230 http://www.ebi.ac.uk/interpro/entry/IPR024230 InterPro IPR025691 http://www.ebi.ac.uk/interpro/entry/IPR025691 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW5705 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5705 KEGG_Gene eco:b3333 http://www.genome.jp/dbget-bin/www_bget?eco:b3333 KEGG_Orthology KO:K02461 http://www.genome.jp/dbget-bin/www_bget?KO:K02461 KEGG_Pathway ko03070 http://www.genome.jp/kegg-bin/show_pathway?ko03070 OMA HEASGRW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HEASGRW PSORT swissprot:GSPL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GSPL_ECOLI PSORT-B swissprot:GSPL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GSPL_ECOLI PSORT2 swissprot:GSPL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GSPL_ECOLI Pfam PF05134 http://pfam.xfam.org/family/PF05134 Pfam PF12693 http://pfam.xfam.org/family/PF12693 Phobius swissprot:GSPL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GSPL_ECOLI ProteinModelPortal P45763 http://www.proteinmodelportal.org/query/uniprot/P45763 PubMed 11118204 http://www.ncbi.nlm.nih.gov/pubmed/11118204 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8655552 http://www.ncbi.nlm.nih.gov/pubmed/8655552 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417792 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417792 RefSeq WP_001115238 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001115238 STRING 511145.b3333 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3333&targetmode=cogs STRING COG3297 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3297&targetmode=cogs TIGRFAMs TIGR01709 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01709 UniProtKB GSPL_ECOLI http://www.uniprot.org/uniprot/GSPL_ECOLI UniProtKB-AC P45763 http://www.uniprot.org/uniprot/P45763 charge swissprot:GSPL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GSPL_ECOLI eggNOG COG3297 http://eggnogapi.embl.de/nog_data/html/tree/COG3297 eggNOG ENOG41063JA http://eggnogapi.embl.de/nog_data/html/tree/ENOG41063JA epestfind swissprot:GSPL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GSPL_ECOLI garnier swissprot:GSPL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GSPL_ECOLI helixturnhelix swissprot:GSPL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GSPL_ECOLI hmoment swissprot:GSPL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GSPL_ECOLI iep swissprot:GSPL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GSPL_ECOLI inforesidue swissprot:GSPL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GSPL_ECOLI octanol swissprot:GSPL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GSPL_ECOLI pepcoil swissprot:GSPL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GSPL_ECOLI pepdigest swissprot:GSPL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GSPL_ECOLI pepinfo swissprot:GSPL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GSPL_ECOLI pepnet swissprot:GSPL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GSPL_ECOLI pepstats swissprot:GSPL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GSPL_ECOLI pepwheel swissprot:GSPL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GSPL_ECOLI pepwindow swissprot:GSPL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GSPL_ECOLI sigcleave swissprot:GSPL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GSPL_ECOLI ## Database ID URL or Descriptions # AltName Ribonuclease Z homolog {ECO:0000255|HAMAP-Rule MF_01818} # BRENDA 3.1.26.11 2026 # BioGrid 4263118 10 # CAUTION Was initially thought to be an arylsulfatase, given its similarity with the AtsA family. PubMed:12029081 however showed that it is a zinc phosphodiesterase. {ECO 0000305}. # COFACTOR RBN_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 12029081}; Note=Binds 2 Zn(2+) ions. {ECO 0000269|PubMed 12029081}; # DISRUPTION PHENOTYPE Mutants are unaffected in growth. {ECO:0000269|PubMed 15764599}. # ENZYME REGULATION RBN_ECOLI Activated by cobalt and manganese. Strongly inhibited by the presence of a 3'-CCA sequence or a 3'-phosphoryl group. {ECO 0000269|PubMed 15764599, ECO 0000269|PubMed 19366704, ECO 0000269|PubMed 20489203}. # EcoGene EG14260 rbn # FUNCTION RBN_ECOLI Zinc phosphodiesterase, which has both exoribonuclease and endoribonuclease activities, depending on the nature of the substrate and of the added divalent cation, and on its 3'-terminal structure. Can process the 3' termini of both CCA-less and CCA- containing tRNA precursors. CCA-less tRNAs are cleaved endonucleolytically after the discriminator base, whereas residues following the CCA sequence can be removed exonucleolytically or endonucleolytically in CCA-containing molecules. Does not remove the CCA sequence. May also be involved in the degradation of mRNAs. In vitro, hydrolyzes bis(p-nitrophenyl)phosphate and thymidine-5'-p-nitrophenyl phosphate. {ECO 0000269|PubMed 12029081, ECO 0000269|PubMed 15764599, ECO 0000269|PubMed 16629673, ECO 0000269|PubMed 19366704, ECO 0000269|PubMed 20489203}. # GO_function GO:0004518 nuclease activity; IDA:EcoliWiki. # GO_function GO:0004532 exoribonuclease activity; IDA:EcoliWiki. # GO_function GO:0008270 zinc ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0042781 3'-tRNA processing endoribonuclease activity; IBA:GO_Central. # GO_process GO:0008033 tRNA processing; IDA:EcoliWiki. # GOslim_function GO:0004518 nuclease activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # Gene3D 3.60.15.10 -; 2. # HAMAP MF_01818 RNase_Z_BN # IntAct P0A8V0 7 # InterPro IPR001279 Metallo-B-lactamas # InterPro IPR013469 Rbn # InterPro IPR013471 RNase_Z/BN # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # KEGG_Pathway ko03013 RNA transport # Organism RBN_ECOLI Escherichia coli (strain K12) # PATRIC 32119903 VBIEscCol129921_2361 # PDB 2CBN X-ray; 2.90 A; A=1-305 # PIR B64998 B64998 # Pfam PF12706 Lactamase_B_2; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Ribonuclease BN {ECO:0000255|HAMAP-Rule MF_01818} # RefSeq NP_416771 NC_000913.3 # RefSeq WP_001300687 NZ_LN832404.1 # SIMILARITY Belongs to the RNase Z family. RNase BN subfamily. {ECO:0000255|HAMAP-Rule MF_01818, ECO:0000305}. # SMART SM00849 Lactamase_B # SUBUNIT RBN_ECOLI Homodimer. {ECO 0000269|PubMed 15764599, ECO 0000269|PubMed 16452444}. # SUPFAM SSF56281 SSF56281 # TIGRFAMs TIGR02649 true_RNase_BN # TIGRFAMs TIGR02651 RNase_Z # eggNOG COG1234 LUCA # eggNOG ENOG4105IES Bacteria BLAST swissprot:RBN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RBN_ECOLI BioCyc ECOL316407:JW2263-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2263-MONOMER BioCyc EcoCyc:G7175-MONOMER http://biocyc.org/getid?id=EcoCyc:G7175-MONOMER BioCyc MetaCyc:G7175-MONOMER http://biocyc.org/getid?id=MetaCyc:G7175-MONOMER COG COG1234 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1234 DIP DIP-9498N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9498N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.C500098200 http://dx.doi.org/10.1074/jbc.C500098200 DOI 10.1074/jbc.M109.005462 http://dx.doi.org/10.1074/jbc.M109.005462 DOI 10.1074/jbc.M110.141101 http://dx.doi.org/10.1074/jbc.M110.141101 DOI 10.1074/jbc.M112047200 http://dx.doi.org/10.1074/jbc.M112047200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1365-2958.2006.05124.x http://dx.doi.org/10.1111/j.1365-2958.2006.05124.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.188.4.1607-1614.2006 http://dx.doi.org/10.1128/JB.188.4.1607-1614.2006 EC_number EC:3.1.-.- {ECO:0000255|HAMAP-Rule:MF_01818} http://www.genome.jp/dbget-bin/www_bget?EC:3.1.-.- {ECO:0000255|HAMAP-Rule:MF_01818} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U58768 http://www.ebi.ac.uk/ena/data/view/U58768 ENZYME 3.1.-.- {ECO:0000255|HAMAP-Rule:MF_01818} http://enzyme.expasy.org/EC/3.1.-.- {ECO:0000255|HAMAP-Rule:MF_01818} EchoBASE EB4008 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4008 EcoGene EG14260 http://www.ecogene.org/geneInfo.php?eg_id=EG14260 EnsemblBacteria AAC75328 http://www.ensemblgenomes.org/id/AAC75328 EnsemblBacteria AAC75328 http://www.ensemblgenomes.org/id/AAC75328 EnsemblBacteria BAA16095 http://www.ensemblgenomes.org/id/BAA16095 EnsemblBacteria BAA16095 http://www.ensemblgenomes.org/id/BAA16095 EnsemblBacteria BAA16095 http://www.ensemblgenomes.org/id/BAA16095 EnsemblBacteria b2268 http://www.ensemblgenomes.org/id/b2268 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GO_function GO:0004532 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004532 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0042781 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042781 GO_process GO:0008033 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008033 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 Gene3D 3.60.15.10 http://www.cathdb.info/version/latest/superfamily/3.60.15.10 GeneID 946760 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946760 HAMAP MF_01818 http://hamap.expasy.org/unirule/MF_01818 HOGENOM HOG000272419 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000272419&db=HOGENOM6 InParanoid P0A8V0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8V0 IntAct P0A8V0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8V0* IntEnz 3.1.-.- {ECO:0000255|HAMAP-Rule:MF_01818} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_01818} InterPro IPR001279 http://www.ebi.ac.uk/interpro/entry/IPR001279 InterPro IPR013469 http://www.ebi.ac.uk/interpro/entry/IPR013469 InterPro IPR013471 http://www.ebi.ac.uk/interpro/entry/IPR013471 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW2263 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2263 KEGG_Gene eco:b2268 http://www.genome.jp/dbget-bin/www_bget?eco:b2268 KEGG_Orthology KO:K00784 http://www.genome.jp/dbget-bin/www_bget?KO:K00784 KEGG_Pathway ko03013 http://www.genome.jp/kegg-bin/show_pathway?ko03013 MINT MINT-1275952 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1275952 OMA SYAFCSD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SYAFCSD PDB 2CBN http://www.ebi.ac.uk/pdbe-srv/view/entry/2CBN PDBsum 2CBN http://www.ebi.ac.uk/pdbsum/2CBN PSORT swissprot:RBN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RBN_ECOLI PSORT-B swissprot:RBN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RBN_ECOLI PSORT2 swissprot:RBN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RBN_ECOLI Pfam PF12706 http://pfam.xfam.org/family/PF12706 Phobius swissprot:RBN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RBN_ECOLI PhylomeDB P0A8V0 http://phylomedb.org/?seqid=P0A8V0 ProteinModelPortal P0A8V0 http://www.proteinmodelportal.org/query/uniprot/P0A8V0 PubMed 12029081 http://www.ncbi.nlm.nih.gov/pubmed/12029081 PubMed 15764599 http://www.ncbi.nlm.nih.gov/pubmed/15764599 PubMed 16452444 http://www.ncbi.nlm.nih.gov/pubmed/16452444 PubMed 16629673 http://www.ncbi.nlm.nih.gov/pubmed/16629673 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19366704 http://www.ncbi.nlm.nih.gov/pubmed/19366704 PubMed 20489203 http://www.ncbi.nlm.nih.gov/pubmed/20489203 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416771 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416771 RefSeq WP_001300687 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300687 SMART SM00849 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00849 SMR P0A8V0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8V0 STRING 511145.b2268 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2268&targetmode=cogs STRING COG1234 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1234&targetmode=cogs SUPFAM SSF56281 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56281 TIGRFAMs TIGR02649 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02649 TIGRFAMs TIGR02651 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02651 UniProtKB RBN_ECOLI http://www.uniprot.org/uniprot/RBN_ECOLI UniProtKB-AC P0A8V0 http://www.uniprot.org/uniprot/P0A8V0 charge swissprot:RBN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RBN_ECOLI eggNOG COG1234 http://eggnogapi.embl.de/nog_data/html/tree/COG1234 eggNOG ENOG4105IES http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105IES epestfind swissprot:RBN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RBN_ECOLI garnier swissprot:RBN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RBN_ECOLI helixturnhelix swissprot:RBN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RBN_ECOLI hmoment swissprot:RBN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RBN_ECOLI iep swissprot:RBN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RBN_ECOLI inforesidue swissprot:RBN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RBN_ECOLI octanol swissprot:RBN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RBN_ECOLI pepcoil swissprot:RBN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RBN_ECOLI pepdigest swissprot:RBN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RBN_ECOLI pepinfo swissprot:RBN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RBN_ECOLI pepnet swissprot:RBN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RBN_ECOLI pepstats swissprot:RBN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RBN_ECOLI pepwheel swissprot:RBN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RBN_ECOLI pepwindow swissprot:RBN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RBN_ECOLI sigcleave swissprot:RBN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RBN_ECOLI ## Database ID URL or Descriptions # AltName GUN_ECOLI Carboxymethylcellulase # AltName GUN_ECOLI Cellulase # AltName GUN_ECOLI Endo-1,4-beta-glucanase # BioGrid 4263272 99 # CATALYTIC ACTIVITY GUN_ECOLI Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans. # CAZy GH8 Glycoside Hydrolase Family 8 # EcoGene EG12258 bcsZ # FUNCTION GUN_ECOLI Hydrolyzes carboxymethylcellulose. # GO_component GO:0005576 extracellular region; IDA:EcoCyc. # GO_function GO:0008810 cellulase activity; IDA:EcoCyc. # GO_process GO:0030245 cellulose catabolic process; IEA:UniProtKB-KW. # GOslim_component GO:0005576 extracellular region # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # Gene3D 1.50.10.10 -; 1. # IntAct P37651 4 # InterPro IPR002037 Glyco_hydro_8 # InterPro IPR008928 6-hairpin_glycosidase-like # InterPro IPR012341 6hp_glycosidase # InterPro IPR019834 Glyco_hydro_8_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00500 Starch and sucrose metabolism # MISCELLANEOUS GUN_ECOLI The genes bscA, bcsB, bcsZ and bcsC are constitutively transcribed but cellulose synthesis occurs only when AdrA, a putative transmembrane protein regulated by AgfD, is expressed. Cellulose production is abolished in E.coli K12. # Organism GUN_ECOLI Escherichia coli (strain K12) # PATHWAY GUN_ECOLI Glycan metabolism; bacterial cellulose biosynthesis. # PATRIC 32122528 VBIEscCol129921_3642 # PDB 3QXF X-ray; 1.85 A; A/B/C/D=22-368 # PDB 3QXQ X-ray; 2.20 A; A/B/C/D=22-368 # PIR S47752 S47752 # PRINTS PR00735 GLHYDRLASE8 # PROSITE PS00812 GLYCOSYL_HYDROL_F8 # Pfam PF01270 Glyco_hydro_8 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GUN_ECOLI Endoglucanase # RefSeq NP_417988 NC_000913.3 # RefSeq WP_001311203 NZ_LN832404.1 # SIMILARITY Belongs to the glycosyl hydrolase 8 (cellulase D) family. {ECO 0000305}. # SUBCELLULAR LOCATION GUN_ECOLI Secreted. # SUPFAM SSF48208 SSF48208 # TCDB 4.D.3.1 the glycan glucosyl transferase (opgh) family # eggNOG COG3405 LUCA # eggNOG ENOG4105K2Z Bacteria BLAST swissprot:GUN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GUN_ECOLI BioCyc ECOL316407:JW3499-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3499-MONOMER BioCyc EcoCyc:EG12258-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12258-MONOMER BioCyc MetaCyc:EG12258-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12258-MONOMER COG COG3405 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3405 DOI 10.1007/s004380050962 http://dx.doi.org/10.1007/s004380050962 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2001.02337.x http://dx.doi.org/10.1046/j.1365-2958.2001.02337.x DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.2.1.4 http://www.genome.jp/dbget-bin/www_bget?EC:3.2.1.4 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.2.1.4 http://enzyme.expasy.org/EC/3.2.1.4 EchoBASE EB2167 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2167 EcoGene EG12258 http://www.ecogene.org/geneInfo.php?eg_id=EG12258 EnsemblBacteria AAC76556 http://www.ensemblgenomes.org/id/AAC76556 EnsemblBacteria AAC76556 http://www.ensemblgenomes.org/id/AAC76556 EnsemblBacteria BAE77763 http://www.ensemblgenomes.org/id/BAE77763 EnsemblBacteria BAE77763 http://www.ensemblgenomes.org/id/BAE77763 EnsemblBacteria BAE77763 http://www.ensemblgenomes.org/id/BAE77763 EnsemblBacteria b3531 http://www.ensemblgenomes.org/id/b3531 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005576 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576 GO_function GO:0008810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008810 GO_process GO:0030245 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030245 GOslim_component GO:0005576 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 1.50.10.10 http://www.cathdb.info/version/latest/superfamily/1.50.10.10 GeneID 948046 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948046 HOGENOM HOG000259088 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000259088&db=HOGENOM6 InParanoid P37651 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37651 IntAct P37651 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37651* IntEnz 3.2.1.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.2.1.4 InterPro IPR002037 http://www.ebi.ac.uk/interpro/entry/IPR002037 InterPro IPR008928 http://www.ebi.ac.uk/interpro/entry/IPR008928 InterPro IPR012341 http://www.ebi.ac.uk/interpro/entry/IPR012341 InterPro IPR019834 http://www.ebi.ac.uk/interpro/entry/IPR019834 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3499 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3499 KEGG_Gene eco:b3531 http://www.genome.jp/dbget-bin/www_bget?eco:b3531 KEGG_Orthology KO:K01179 http://www.genome.jp/dbget-bin/www_bget?KO:K01179 KEGG_Pathway ko00500 http://www.genome.jp/kegg-bin/show_pathway?ko00500 KEGG_Reaction rn:R02886 http://www.genome.jp/dbget-bin/www_bget?rn:R02886 KEGG_Reaction rn:R06200 http://www.genome.jp/dbget-bin/www_bget?rn:R06200 OMA IRVYLWV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IRVYLWV PDB 3QXF http://www.ebi.ac.uk/pdbe-srv/view/entry/3QXF PDB 3QXQ http://www.ebi.ac.uk/pdbe-srv/view/entry/3QXQ PDBsum 3QXF http://www.ebi.ac.uk/pdbsum/3QXF PDBsum 3QXQ http://www.ebi.ac.uk/pdbsum/3QXQ PRINTS PR00735 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00735 PROSITE PS00812 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00812 PSORT swissprot:GUN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GUN_ECOLI PSORT-B swissprot:GUN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GUN_ECOLI PSORT2 swissprot:GUN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GUN_ECOLI Pfam PF01270 http://pfam.xfam.org/family/PF01270 Phobius swissprot:GUN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GUN_ECOLI ProteinModelPortal P37651 http://www.proteinmodelportal.org/query/uniprot/P37651 PubMed 10102357 http://www.ncbi.nlm.nih.gov/pubmed/10102357 PubMed 11260463 http://www.ncbi.nlm.nih.gov/pubmed/11260463 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417988 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417988 RefSeq WP_001311203 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001311203 SMR P37651 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37651 STRING 511145.b3531 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3531&targetmode=cogs STRING COG3405 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3405&targetmode=cogs SUPFAM SSF48208 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48208 TCDB 4.D.3.1 http://www.tcdb.org/search/result.php?tc=4.D.3.1 UniProtKB GUN_ECOLI http://www.uniprot.org/uniprot/GUN_ECOLI UniProtKB-AC P37651 http://www.uniprot.org/uniprot/P37651 charge swissprot:GUN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GUN_ECOLI eggNOG COG3405 http://eggnogapi.embl.de/nog_data/html/tree/COG3405 eggNOG ENOG4105K2Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K2Z epestfind swissprot:GUN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GUN_ECOLI garnier swissprot:GUN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GUN_ECOLI helixturnhelix swissprot:GUN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GUN_ECOLI hmoment swissprot:GUN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GUN_ECOLI iep swissprot:GUN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GUN_ECOLI inforesidue swissprot:GUN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GUN_ECOLI octanol swissprot:GUN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GUN_ECOLI pepcoil swissprot:GUN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GUN_ECOLI pepdigest swissprot:GUN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GUN_ECOLI pepinfo swissprot:GUN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GUN_ECOLI pepnet swissprot:GUN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GUN_ECOLI pepstats swissprot:GUN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GUN_ECOLI pepwheel swissprot:GUN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GUN_ECOLI pepwindow swissprot:GUN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GUN_ECOLI sigcleave swissprot:GUN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GUN_ECOLI ## Database ID URL or Descriptions # BioGrid 4259259 11 # EcoGene EG12749 yhaJ # FUNCTION YHAJ_ECOLI Positive regulator, may be partially responsible for expression of neighboring gene dlsT (yhaO) (By similarity). {ECO 0000250|UniProtKB P67661}. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; ISS:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # IntAct P67660 13 # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR005119 LysR_subst-bd # InterPro IPR011991 WHTH_DNA-bd_dom # Organism YHAJ_ECOLI Escherichia coli (strain K12) # PATRIC 32121630 VBIEscCol129921_3201 # PIR F65099 F65099 # PROSITE PS50931 HTH_LYSR # Pfam PF00126 HTH_1 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHAJ_ECOLI Probable HTH-type transcriptional regulator YhaJ # RefSeq NP_417576 NC_000913.3 # RefSeq WP_001041009 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lysR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00253}. # SUPFAM SSF46785 SSF46785 # eggNOG ENOG4105CWB Bacteria # eggNOG ENOG410XP36 LUCA BLAST swissprot:YHAJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHAJ_ECOLI BioCyc ECOL316407:JW3076-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3076-MONOMER BioCyc EcoCyc:G7619-MONOMER http://biocyc.org/getid?id=EcoCyc:G7619-MONOMER DIP DIP-35869N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35869N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2605 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2605 EcoGene EG12749 http://www.ecogene.org/geneInfo.php?eg_id=EG12749 EnsemblBacteria AAC76140 http://www.ensemblgenomes.org/id/AAC76140 EnsemblBacteria AAC76140 http://www.ensemblgenomes.org/id/AAC76140 EnsemblBacteria BAE77155 http://www.ensemblgenomes.org/id/BAE77155 EnsemblBacteria BAE77155 http://www.ensemblgenomes.org/id/BAE77155 EnsemblBacteria BAE77155 http://www.ensemblgenomes.org/id/BAE77155 EnsemblBacteria b3105 http://www.ensemblgenomes.org/id/b3105 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 947621 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947621 HOGENOM HOG000181312 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000181312&db=HOGENOM6 InParanoid P67660 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P67660 IntAct P67660 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P67660* InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW3076 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3076 KEGG_Gene eco:b3105 http://www.genome.jp/dbget-bin/www_bget?eco:b3105 MINT MINT-1250735 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1250735 OMA YVHKRSG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YVHKRSG PROSITE PS50931 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50931 PSORT swissprot:YHAJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHAJ_ECOLI PSORT-B swissprot:YHAJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHAJ_ECOLI PSORT2 swissprot:YHAJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHAJ_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:YHAJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHAJ_ECOLI PhylomeDB P67660 http://phylomedb.org/?seqid=P67660 ProteinModelPortal P67660 http://www.proteinmodelportal.org/query/uniprot/P67660 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417576 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417576 RefSeq WP_001041009 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001041009 STRING 511145.b3105 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3105&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB YHAJ_ECOLI http://www.uniprot.org/uniprot/YHAJ_ECOLI UniProtKB-AC P67660 http://www.uniprot.org/uniprot/P67660 charge swissprot:YHAJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHAJ_ECOLI eggNOG ENOG4105CWB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CWB eggNOG ENOG410XP36 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XP36 epestfind swissprot:YHAJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHAJ_ECOLI garnier swissprot:YHAJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHAJ_ECOLI helixturnhelix swissprot:YHAJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHAJ_ECOLI hmoment swissprot:YHAJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHAJ_ECOLI iep swissprot:YHAJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHAJ_ECOLI inforesidue swissprot:YHAJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHAJ_ECOLI octanol swissprot:YHAJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHAJ_ECOLI pepcoil swissprot:YHAJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHAJ_ECOLI pepdigest swissprot:YHAJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHAJ_ECOLI pepinfo swissprot:YHAJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHAJ_ECOLI pepnet swissprot:YHAJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHAJ_ECOLI pepstats swissprot:YHAJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHAJ_ECOLI pepwheel swissprot:YHAJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHAJ_ECOLI pepwindow swissprot:YHAJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHAJ_ECOLI sigcleave swissprot:YHAJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHAJ_ECOLI ## Database ID URL or Descriptions # AltName SDHM_ECOLI L-serine deaminase 2 # BRENDA 4.3.1.17 2026 # BioGrid 4261306 9 # CATALYTIC ACTIVITY SDHM_ECOLI L-serine = pyruvate + NH(3). # COFACTOR SDHM_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000305}; Note=Binds 1 [4Fe-4S] cluster. {ECO 0000305}; # EcoGene EG11623 sdaB # FUNCTION SDHM_ECOLI Deaminates also threonine, particularly when it is present in high concentration. # GO_function GO:0003941 L-serine ammonia-lyase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0006094 gluconeogenesis; IEA:UniProtKB-UniPathway. # GO_process GO:0006565 L-serine catabolic process; IDA:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.30.1330.90 -; 1. # INDUCTION Transcribed in rich medium, particularly in the absence of glucose, and is under the control of catabolite activator protein. It is made aerobically and anaerobically. Repressed by LeuO. Part of the sdaCB operon. {ECO:0000269|PubMed 19429622}. # IntAct P30744 2 # InterPro IPR004644 Fe-S_L-Ser_mono # InterPro IPR005130 Ser_deHydtase-like_asu # InterPro IPR005131 Ser_deHydtase_bsu # InterPro IPR029009 ASB_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00260 Glycine, serine and threonine metabolism # KEGG_Pathway ko00270 Cysteine and methionine metabolism # Organism SDHM_ECOLI Escherichia coli (strain K12) # PATHWAY SDHM_ECOLI Carbohydrate biosynthesis; gluconeogenesis. # PATRIC 32121010 VBIEscCol129921_2897 # PIR A65062 A65062 # PTM SDHM_ECOLI Activated by post-translational modification by a system involving at least three gene products. Activation is mimicked in vitro by iron and dithiothreitol. There is considerable evidence for a free-radical activation mechanism. # Pfam PF03313 SDH_alpha # Pfam PF03315 SDH_beta # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SDHM_ECOLI L-serine dehydratase 2 # RefSeq NP_417277 NC_000913.3 # RefSeq WP_000626422 NZ_LN832404.1 # SIMILARITY Belongs to the iron-sulfur dependent L-serine dehydratase family. {ECO 0000305}. # SUPFAM SSF143548 SSF143548 # TIGRFAMs TIGR00720 sda_mono # eggNOG COG1760 LUCA # eggNOG ENOG4105EJQ Bacteria BLAST swissprot:SDHM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SDHM_ECOLI BioCyc ECOL316407:JW2768-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2768-MONOMER BioCyc EcoCyc:LSERINEDEAM2-MONOMER http://biocyc.org/getid?id=EcoCyc:LSERINEDEAM2-MONOMER BioCyc MetaCyc:LSERINEDEAM2-MONOMER http://biocyc.org/getid?id=MetaCyc:LSERINEDEAM2-MONOMER COG COG1760 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1760 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1432-1033.1993.tb17718.x http://dx.doi.org/10.1111/j.1432-1033.1993.tb17718.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00108-09 http://dx.doi.org/10.1128/JB.00108-09 EC_number EC:4.3.1.17 http://www.genome.jp/dbget-bin/www_bget?EC:4.3.1.17 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L07763 http://www.ebi.ac.uk/ena/data/view/L07763 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 ENZYME 4.3.1.17 http://enzyme.expasy.org/EC/4.3.1.17 EchoBASE EB1580 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1580 EcoGene EG11623 http://www.ecogene.org/geneInfo.php?eg_id=EG11623 EnsemblBacteria AAC75839 http://www.ensemblgenomes.org/id/AAC75839 EnsemblBacteria AAC75839 http://www.ensemblgenomes.org/id/AAC75839 EnsemblBacteria BAE76869 http://www.ensemblgenomes.org/id/BAE76869 EnsemblBacteria BAE76869 http://www.ensemblgenomes.org/id/BAE76869 EnsemblBacteria BAE76869 http://www.ensemblgenomes.org/id/BAE76869 EnsemblBacteria b2797 http://www.ensemblgenomes.org/id/b2797 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003941 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003941 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0006094 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006094 GO_process GO:0006565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006565 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.30.1330.90 http://www.cathdb.info/version/latest/superfamily/3.30.1330.90 GeneID 947262 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947262 HOGENOM HOG000036732 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000036732&db=HOGENOM6 InParanoid P30744 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30744 IntAct P30744 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P30744* IntEnz 4.3.1.17 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.3.1.17 InterPro IPR004644 http://www.ebi.ac.uk/interpro/entry/IPR004644 InterPro IPR005130 http://www.ebi.ac.uk/interpro/entry/IPR005130 InterPro IPR005131 http://www.ebi.ac.uk/interpro/entry/IPR005131 InterPro IPR029009 http://www.ebi.ac.uk/interpro/entry/IPR029009 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2768 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2768 KEGG_Gene eco:b2797 http://www.genome.jp/dbget-bin/www_bget?eco:b2797 KEGG_Orthology KO:K01752 http://www.genome.jp/dbget-bin/www_bget?KO:K01752 KEGG_Pathway ko00260 http://www.genome.jp/kegg-bin/show_pathway?ko00260 KEGG_Pathway ko00270 http://www.genome.jp/kegg-bin/show_pathway?ko00270 KEGG_Reaction rn:R00220 http://www.genome.jp/dbget-bin/www_bget?rn:R00220 KEGG_Reaction rn:R00590 http://www.genome.jp/dbget-bin/www_bget?rn:R00590 OMA LENELTW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LENELTW PSORT swissprot:SDHM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SDHM_ECOLI PSORT-B swissprot:SDHM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SDHM_ECOLI PSORT2 swissprot:SDHM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SDHM_ECOLI Pfam PF03313 http://pfam.xfam.org/family/PF03313 Pfam PF03315 http://pfam.xfam.org/family/PF03315 Phobius swissprot:SDHM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SDHM_ECOLI PhylomeDB P30744 http://phylomedb.org/?seqid=P30744 ProteinModelPortal P30744 http://www.proteinmodelportal.org/query/uniprot/P30744 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19429622 http://www.ncbi.nlm.nih.gov/pubmed/19429622 PubMed 8385012 http://www.ncbi.nlm.nih.gov/pubmed/8385012 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417277 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417277 RefSeq WP_000626422 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000626422 SMR P30744 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P30744 STRING 511145.b2797 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2797&targetmode=cogs STRING COG1760 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1760&targetmode=cogs SUPFAM SSF143548 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF143548 TIGRFAMs TIGR00720 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00720 UniProtKB SDHM_ECOLI http://www.uniprot.org/uniprot/SDHM_ECOLI UniProtKB-AC P30744 http://www.uniprot.org/uniprot/P30744 charge swissprot:SDHM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SDHM_ECOLI eggNOG COG1760 http://eggnogapi.embl.de/nog_data/html/tree/COG1760 eggNOG ENOG4105EJQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EJQ epestfind swissprot:SDHM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SDHM_ECOLI garnier swissprot:SDHM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SDHM_ECOLI helixturnhelix swissprot:SDHM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SDHM_ECOLI hmoment swissprot:SDHM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SDHM_ECOLI iep swissprot:SDHM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SDHM_ECOLI inforesidue swissprot:SDHM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SDHM_ECOLI octanol swissprot:SDHM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SDHM_ECOLI pepcoil swissprot:SDHM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SDHM_ECOLI pepdigest swissprot:SDHM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SDHM_ECOLI pepinfo swissprot:SDHM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SDHM_ECOLI pepnet swissprot:SDHM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SDHM_ECOLI pepstats swissprot:SDHM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SDHM_ECOLI pepwheel swissprot:SDHM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SDHM_ECOLI pepwindow swissprot:SDHM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SDHM_ECOLI sigcleave swissprot:SDHM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SDHM_ECOLI ## Database ID URL or Descriptions # AltName Sigma cross-reacting protein 27A {ECO:0000303|PubMed 1575737} # BIOPHYSICOCHEMICAL PROPERTIES ELBB_ECOLI Kinetic parameters KM=1.21 mM for glyoxal (at pH 7.4 and 37 degrees Celsius) {ECO 0000269|PubMed 26678554}; Note=kcat is 0.48 min(-1) with glyoxal as substrate (at pH 7.4 and 37 degrees Celsius). {ECO 0000269|PubMed 26678554}; # BioGrid 4262428 8 # CATALYTIC ACTIVITY Glycolate = glyoxal + H(2)O. {ECO:0000269|PubMed 26678554}. # CAUTION Was originally thought (PubMed:9603997) to be involved in the early steps of isoprenoid biosynthesis. {ECO 0000305}. # EcoGene EG11383 elbB # FUNCTION ELBB_ECOLI Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate (PubMed 26678554). However, this apparent glyoxalase activity may reflect a protein deglycase activity, which could be the primary function of this protein like other DJ- 1 superfamily members such as PARK7, YajL, YhbO and HchA (Probable). Is not able to use methylglyoxal as substrate (PubMed 26678554). {ECO 0000269|PubMed 26678554, ECO 0000305}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0016829 lyase activity; IEA:UniProtKB-KW. # GO_process GO:0008299 isoprenoid biosynthetic process; IMP:EcoliWiki. # GO_process GO:0045828 positive regulation of isoprenoid metabolic process; IMP:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.880 -; 1. # IntAct P0ABU5 6 # InterPro IPR026041 ElbB # InterPro IPR029062 Class_I_gatase-like # Organism ELBB_ECOLI Escherichia coli (strain K12) # PATRIC 32121838 VBIEscCol129921_3303 # PDB 1OY1 X-ray; 2.95 A; A/B/C/D=1-217 # PDB 1VHQ X-ray; 1.65 A; A/B=1-217 # PIR C65112 C65112 # PIRSF PIRSF006320 Elb2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Glyoxalase ElbB {ECO:0000303|PubMed 26678554} # RefSeq NP_417676 NC_000913.3 # RefSeq WP_001300411 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA58011.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the peptidase C56 family. {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000305|PubMed 16021622, ECO:0000305|Ref.7}. # SUPFAM SSF52317 SSF52317 # eggNOG COG3155 LUCA # eggNOG ENOG4108556 Bacteria BLAST swissprot:ELBB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ELBB_ECOLI BioCyc ECOL316407:JW3176-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3176-MONOMER BioCyc EcoCyc:EG11383-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11383-MONOMER DIP DIP-48002N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48002N DOI 10.1002/prot.20541 http://dx.doi.org/10.1002/prot.20541 DOI 10.1016/0006-291X(92)90636-Y http://dx.doi.org/10.1016/0006-291X(92)90636-Y DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/femsle/fnv239 http://dx.doi.org/10.1093/femsle/fnv239 DOI 10.1093/oxfordjournals.jbchem.a022047 http://dx.doi.org/10.1093/oxfordjournals.jbchem.a022047 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.1.- {ECO:0000269|PubMed:26678554} http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.- {ECO:0000269|PubMed:26678554} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D13188 http://www.ebi.ac.uk/ena/data/view/D13188 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 4.2.1.- {ECO:0000269|PubMed:26678554} http://enzyme.expasy.org/EC/4.2.1.- {ECO:0000269|PubMed:26678554} EchoBASE EB1356 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1356 EcoGene EG11383 http://www.ecogene.org/geneInfo.php?eg_id=EG11383 EnsemblBacteria AAC76241 http://www.ensemblgenomes.org/id/AAC76241 EnsemblBacteria AAC76241 http://www.ensemblgenomes.org/id/AAC76241 EnsemblBacteria BAE77253 http://www.ensemblgenomes.org/id/BAE77253 EnsemblBacteria BAE77253 http://www.ensemblgenomes.org/id/BAE77253 EnsemblBacteria BAE77253 http://www.ensemblgenomes.org/id/BAE77253 EnsemblBacteria b3209 http://www.ensemblgenomes.org/id/b3209 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GO_process GO:0008299 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008299 GO_process GO:0045828 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045828 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.880 http://www.cathdb.info/version/latest/superfamily/3.40.50.880 GeneID 947903 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947903 HOGENOM HOG000269874 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000269874&db=HOGENOM6 InParanoid P0ABU5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABU5 IntAct P0ABU5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABU5* IntEnz 4.2.1.- {ECO:0000269|PubMed:26678554} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.- {ECO:0000269|PubMed:26678554} InterPro IPR026041 http://www.ebi.ac.uk/interpro/entry/IPR026041 InterPro IPR029062 http://www.ebi.ac.uk/interpro/entry/IPR029062 KEGG_Gene ecj:JW3176 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3176 KEGG_Gene eco:b3209 http://www.genome.jp/dbget-bin/www_bget?eco:b3209 OMA AQVQCFA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AQVQCFA PDB 1OY1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1OY1 PDB 1VHQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1VHQ PDBsum 1OY1 http://www.ebi.ac.uk/pdbsum/1OY1 PDBsum 1VHQ http://www.ebi.ac.uk/pdbsum/1VHQ PSORT swissprot:ELBB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ELBB_ECOLI PSORT-B swissprot:ELBB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ELBB_ECOLI PSORT2 swissprot:ELBB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ELBB_ECOLI Phobius swissprot:ELBB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ELBB_ECOLI PhylomeDB P0ABU5 http://phylomedb.org/?seqid=P0ABU5 ProteinModelPortal P0ABU5 http://www.proteinmodelportal.org/query/uniprot/P0ABU5 PubMed 1575737 http://www.ncbi.nlm.nih.gov/pubmed/1575737 PubMed 16021622 http://www.ncbi.nlm.nih.gov/pubmed/16021622 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 26678554 http://www.ncbi.nlm.nih.gov/pubmed/26678554 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9603997 http://www.ncbi.nlm.nih.gov/pubmed/9603997 RefSeq NP_417676 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417676 RefSeq WP_001300411 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300411 SMR P0ABU5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABU5 STRING 511145.b3209 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3209&targetmode=cogs SUPFAM SSF52317 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52317 SWISS-2DPAGE P0ABU5 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0ABU5 UniProtKB ELBB_ECOLI http://www.uniprot.org/uniprot/ELBB_ECOLI UniProtKB-AC P0ABU5 http://www.uniprot.org/uniprot/P0ABU5 charge swissprot:ELBB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ELBB_ECOLI eggNOG COG3155 http://eggnogapi.embl.de/nog_data/html/tree/COG3155 eggNOG ENOG4108556 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108556 epestfind swissprot:ELBB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ELBB_ECOLI garnier swissprot:ELBB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ELBB_ECOLI helixturnhelix swissprot:ELBB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ELBB_ECOLI hmoment swissprot:ELBB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ELBB_ECOLI iep swissprot:ELBB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ELBB_ECOLI inforesidue swissprot:ELBB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ELBB_ECOLI octanol swissprot:ELBB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ELBB_ECOLI pepcoil swissprot:ELBB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ELBB_ECOLI pepdigest swissprot:ELBB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ELBB_ECOLI pepinfo swissprot:ELBB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ELBB_ECOLI pepnet swissprot:ELBB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ELBB_ECOLI pepstats swissprot:ELBB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ELBB_ECOLI pepwheel swissprot:ELBB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ELBB_ECOLI pepwindow swissprot:ELBB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ELBB_ECOLI sigcleave swissprot:ELBB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ELBB_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES ISPH_ECOLI Kinetic parameters KM=30 uM for 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate {ECO 0000269|PubMed 15469281}; pH dependence Optimum pH is 7.0.; # BioGrid 4262917 321 # CATALYTIC ACTIVITY ISPH_ECOLI Dimethylallyl diphosphate + 2 oxidized ferredoxin [iron-sulfur] cluster + H(2)O = (E)-4-hydroxy-3- methylbut-2-en-1-yl diphosphate + 2 reduced ferredoxin [iron- sulfur] cluster + 2 H(+). {ECO 0000269|PubMed 12198182, ECO 0000269|PubMed 12571359}. # CATALYTIC ACTIVITY ISPH_ECOLI Isopentenyl diphosphate + 2 oxidized ferredoxin [iron-sulfur] cluster + H(2)O = (E)-4-hydroxy-3- methylbut-2-en-1-yl diphosphate + 2 reduced ferredoxin [iron- sulfur] cluster + 2 H(+). {ECO 0000269|PubMed 12198182, ECO 0000269|PubMed 12571359}. # CDD cd13944 lytB_ispH # COFACTOR ISPH_ECOLI Name=[3Fe-4S] cluster; Xref=ChEBI CHEBI 21137; Evidence={ECO 0000269|PubMed 19569147, ECO 0000269|PubMed 20080550, ECO 0000269|PubMed 22137895}; Note=Binds 1 [3Fe-4S] cluster per subunit. {ECO 0000269|PubMed 19569147, ECO 0000269|PubMed 20080550, ECO 0000269|PubMed 22137895}; # ENZYME REGULATION Addition of Ca(2+), Mg(2+), Mn(2+), Ni(2+), Co(2+) or Fe(2+) decreases the activity. Addition of Zn(2+) results in complete loss of activity. {ECO:0000269|PubMed 15469281}. # EcoGene EG11081 ispH # FUNCTION ISPH_ECOLI Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Is also involved in penicillin tolerance and control of the stringent response. Seems to directly or indirectly interact with RelA to maintain it in an inactive form during normal growth. {ECO 0000269|PubMed 19569147, ECO 0000269|PubMed 20080550, ECO 0000269|PubMed 22137895}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0042380 hydroxymethylbutenyl pyrophosphate reductase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051538 3 iron, 4 sulfur cluster binding; IDA:EcoCyc. # GO_function GO:0051745 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity; IEA:UniProtKB-HAMAP. # GO_process GO:0016114 terpenoid biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0019288 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway; IMP:EcoCyc. # GO_process GO:0050992 dimethylallyl diphosphate biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # HAMAP MF_00191 IspH # IntAct P62623 7 # InterPro IPR003451 LytB/IspH # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00900 Terpenoid backbone biosynthesis # MISCELLANEOUS PubMed:12706830 and PubMed 22137895 authors have reported the presence of a 4Fe-4S iron-sulfur cluster. It could be due to experimental conditions. # Organism ISPH_ECOLI Escherichia coli (strain K12) # PATHWAY Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3- methylbutenyl diphosphate step 1/1. # PATHWAY Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1- deoxy-D-xylulose 5-phosphate step 6/6. # PATRIC 32115149 VBIEscCol129921_0026 # PDB 3F7T X-ray; 1.80 A; A/B=1-316 # PDB 3KE8 X-ray; 1.70 A; A/B=1-316 # PDB 3KE9 X-ray; 1.90 A; A/B=1-316 # PDB 3KEF X-ray; 1.70 A; A/B=1-316 # PDB 3KEL X-ray; 1.80 A; A/B=1-316 # PDB 3KEM X-ray; 2.00 A; A/B=1-316 # PDB 3SZL X-ray; 1.60 A; A/B=1-316 # PDB 3SZO X-ray; 1.60 A; A/B=1-316 # PDB 3SZU X-ray; 1.40 A; A/B=1-316 # PDB 3T0F X-ray; 1.90 A; A/B=1-316 # PDB 3T0G X-ray; 2.10 A; A/B=1-316 # PDB 3URK X-ray; 1.50 A; A/B=1-316 # PDB 3UTC X-ray; 1.90 A; A/B=1-316 # PDB 3UTD X-ray; 1.70 A; A/B=1-316 # PDB 3UV3 X-ray; 1.60 A; A/B=1-316 # PDB 3UV6 X-ray; 1.70 A; A/B=1-316 # PDB 3UV7 X-ray; 1.60 A; A/B=1-316 # PDB 3UWM X-ray; 1.80 A; A/B=1-316 # PDB 3ZGL X-ray; 1.68 A; A/B=1-316 # PDB 3ZGN X-ray; 1.95 A; A/B=1-316 # PDB 4EB3 X-ray; 1.90 A; A/B=1-315 # PDB 4H4C X-ray; 1.80 A; A/B=1-315 # PDB 4H4D X-ray; 1.35 A; A/B=1-315 # PDB 4H4E X-ray; 1.70 A; A/B=1-315 # PIR JE0403 JE0403 # Pfam PF02401 LYTB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ISPH_ECOLI 4-hydroxy-3-methylbut-2-enyl diphosphate reductase # RefSeq NP_414570 NC_000913.3 # RefSeq WP_001166395 NZ_LN832404.1 # SIMILARITY Belongs to the IspH family. {ECO 0000305}. # SUBUNIT ISPH_ECOLI Homodimer. {ECO 0000269|PubMed 12706830, ECO 0000269|PubMed 19569147, ECO 0000269|PubMed 20080550, ECO 0000269|PubMed 22137895}. # TIGRFAMs TIGR00216 ispH_lytB # UniPathway UPA00056 UER00097 # UniPathway UPA00059 UER00105 # eggNOG COG0761 LUCA # eggNOG ENOG4105C48 Bacteria BLAST swissprot:ISPH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ISPH_ECOLI BioCyc ECOL316407:JW0027-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0027-MONOMER BioCyc EcoCyc:EG11081-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11081-MONOMER BioCyc MetaCyc:EG11081-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11081-MONOMER COG COG0761 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0761 DIP DIP-35808N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35808N DOI 10.1002/anie.200900548 http://dx.doi.org/10.1002/anie.200900548 DOI 10.1016/S0014-5793(01)02516-9 http://dx.doi.org/10.1016/S0014-5793(01)02516-9 DOI 10.1016/S0014-5793(03)00317-X http://dx.doi.org/10.1016/S0014-5793(03)00317-X DOI 10.1016/j.jmb.2011.11.033 http://dx.doi.org/10.1016/j.jmb.2011.11.033 DOI 10.1021/ja0471727 http://dx.doi.org/10.1021/ja0471727 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.032658999 http://dx.doi.org/10.1073/pnas.032658999 DOI 10.1073/pnas.0337742100 http://dx.doi.org/10.1073/pnas.0337742100 DOI 10.1073/pnas.0913045107 http://dx.doi.org/10.1073/pnas.0913045107 DOI 10.1073/pnas.182412599 http://dx.doi.org/10.1073/pnas.182412599 DOI 10.1093/nar/19.1.180 http://dx.doi.org/10.1093/nar/19.1.180 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.183.24.7403-7407.2001 http://dx.doi.org/10.1128/JB.183.24.7403-7407.2001 EC_number EC:1.17.7.4 {ECO:0000269|PubMed:12198182, ECO:0000269|PubMed:12571359} http://www.genome.jp/dbget-bin/www_bget?EC:1.17.7.4 {ECO:0000269|PubMed:12198182, ECO:0000269|PubMed:12571359} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL AY062212 http://www.ebi.ac.uk/ena/data/view/AY062212 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X54945 http://www.ebi.ac.uk/ena/data/view/X54945 ENZYME 1.17.7.4 {ECO:0000269|PubMed:12198182, ECO:0000269|PubMed:12571359} http://enzyme.expasy.org/EC/1.17.7.4 {ECO:0000269|PubMed:12198182, ECO:0000269|PubMed:12571359} EchoBASE EB1073 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1073 EcoGene EG11081 http://www.ecogene.org/geneInfo.php?eg_id=EG11081 EnsemblBacteria AAC73140 http://www.ensemblgenomes.org/id/AAC73140 EnsemblBacteria AAC73140 http://www.ensemblgenomes.org/id/AAC73140 EnsemblBacteria BAB96598 http://www.ensemblgenomes.org/id/BAB96598 EnsemblBacteria BAB96598 http://www.ensemblgenomes.org/id/BAB96598 EnsemblBacteria BAB96598 http://www.ensemblgenomes.org/id/BAB96598 EnsemblBacteria b0029 http://www.ensemblgenomes.org/id/b0029 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0042380 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042380 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051538 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051538 GO_function GO:0051745 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051745 GO_process GO:0016114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016114 GO_process GO:0019288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019288 GO_process GO:0050992 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050992 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 944777 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944777 HAMAP MF_00191 http://hamap.expasy.org/unirule/MF_00191 HOGENOM HOG000220192 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220192&db=HOGENOM6 InParanoid P62623 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P62623 IntAct P62623 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P62623* IntEnz 1.17.7.4 {ECO:0000269|PubMed:12198182, ECO:0000269|PubMed:12571359} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.17.7.4 {ECO:0000269|PubMed:12198182, ECO:0000269|PubMed:12571359} InterPro IPR003451 http://www.ebi.ac.uk/interpro/entry/IPR003451 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0027 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0027 KEGG_Gene eco:b0029 http://www.genome.jp/dbget-bin/www_bget?eco:b0029 KEGG_Orthology KO:K03527 http://www.genome.jp/dbget-bin/www_bget?KO:K03527 KEGG_Pathway ko00900 http://www.genome.jp/kegg-bin/show_pathway?ko00900 KEGG_Reaction rn:R05884 http://www.genome.jp/dbget-bin/www_bget?rn:R05884 KEGG_Reaction rn:R07219 http://www.genome.jp/dbget-bin/www_bget?rn:R07219 KEGG_Reaction rn:R08209 http://www.genome.jp/dbget-bin/www_bget?rn:R08209 KEGG_Reaction rn:R08210 http://www.genome.jp/dbget-bin/www_bget?rn:R08210 OMA DDLTFMT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DDLTFMT PDB 3F7T http://www.ebi.ac.uk/pdbe-srv/view/entry/3F7T PDB 3KE8 http://www.ebi.ac.uk/pdbe-srv/view/entry/3KE8 PDB 3KE9 http://www.ebi.ac.uk/pdbe-srv/view/entry/3KE9 PDB 3KEF http://www.ebi.ac.uk/pdbe-srv/view/entry/3KEF PDB 3KEL http://www.ebi.ac.uk/pdbe-srv/view/entry/3KEL PDB 3KEM http://www.ebi.ac.uk/pdbe-srv/view/entry/3KEM PDB 3SZL http://www.ebi.ac.uk/pdbe-srv/view/entry/3SZL PDB 3SZO http://www.ebi.ac.uk/pdbe-srv/view/entry/3SZO PDB 3SZU http://www.ebi.ac.uk/pdbe-srv/view/entry/3SZU PDB 3T0F http://www.ebi.ac.uk/pdbe-srv/view/entry/3T0F PDB 3T0G http://www.ebi.ac.uk/pdbe-srv/view/entry/3T0G PDB 3URK http://www.ebi.ac.uk/pdbe-srv/view/entry/3URK PDB 3UTC http://www.ebi.ac.uk/pdbe-srv/view/entry/3UTC PDB 3UTD http://www.ebi.ac.uk/pdbe-srv/view/entry/3UTD PDB 3UV3 http://www.ebi.ac.uk/pdbe-srv/view/entry/3UV3 PDB 3UV6 http://www.ebi.ac.uk/pdbe-srv/view/entry/3UV6 PDB 3UV7 http://www.ebi.ac.uk/pdbe-srv/view/entry/3UV7 PDB 3UWM http://www.ebi.ac.uk/pdbe-srv/view/entry/3UWM PDB 3ZGL http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZGL PDB 3ZGN http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZGN PDB 4EB3 http://www.ebi.ac.uk/pdbe-srv/view/entry/4EB3 PDB 4H4C http://www.ebi.ac.uk/pdbe-srv/view/entry/4H4C PDB 4H4D http://www.ebi.ac.uk/pdbe-srv/view/entry/4H4D PDB 4H4E http://www.ebi.ac.uk/pdbe-srv/view/entry/4H4E PDBsum 3F7T http://www.ebi.ac.uk/pdbsum/3F7T PDBsum 3KE8 http://www.ebi.ac.uk/pdbsum/3KE8 PDBsum 3KE9 http://www.ebi.ac.uk/pdbsum/3KE9 PDBsum 3KEF http://www.ebi.ac.uk/pdbsum/3KEF PDBsum 3KEL http://www.ebi.ac.uk/pdbsum/3KEL PDBsum 3KEM http://www.ebi.ac.uk/pdbsum/3KEM PDBsum 3SZL http://www.ebi.ac.uk/pdbsum/3SZL PDBsum 3SZO http://www.ebi.ac.uk/pdbsum/3SZO PDBsum 3SZU http://www.ebi.ac.uk/pdbsum/3SZU PDBsum 3T0F http://www.ebi.ac.uk/pdbsum/3T0F PDBsum 3T0G http://www.ebi.ac.uk/pdbsum/3T0G PDBsum 3URK http://www.ebi.ac.uk/pdbsum/3URK PDBsum 3UTC http://www.ebi.ac.uk/pdbsum/3UTC PDBsum 3UTD http://www.ebi.ac.uk/pdbsum/3UTD PDBsum 3UV3 http://www.ebi.ac.uk/pdbsum/3UV3 PDBsum 3UV6 http://www.ebi.ac.uk/pdbsum/3UV6 PDBsum 3UV7 http://www.ebi.ac.uk/pdbsum/3UV7 PDBsum 3UWM http://www.ebi.ac.uk/pdbsum/3UWM PDBsum 3ZGL http://www.ebi.ac.uk/pdbsum/3ZGL PDBsum 3ZGN http://www.ebi.ac.uk/pdbsum/3ZGN PDBsum 4EB3 http://www.ebi.ac.uk/pdbsum/4EB3 PDBsum 4H4C http://www.ebi.ac.uk/pdbsum/4H4C PDBsum 4H4D http://www.ebi.ac.uk/pdbsum/4H4D PDBsum 4H4E http://www.ebi.ac.uk/pdbsum/4H4E PSORT swissprot:ISPH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ISPH_ECOLI PSORT-B swissprot:ISPH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ISPH_ECOLI PSORT2 swissprot:ISPH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ISPH_ECOLI Pfam PF02401 http://pfam.xfam.org/family/PF02401 Phobius swissprot:ISPH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ISPH_ECOLI PhylomeDB P62623 http://phylomedb.org/?seqid=P62623 ProteinModelPortal P62623 http://www.proteinmodelportal.org/query/uniprot/P62623 PubMed 11418107 http://www.ncbi.nlm.nih.gov/pubmed/11418107 PubMed 11717301 http://www.ncbi.nlm.nih.gov/pubmed/11717301 PubMed 11818558 http://www.ncbi.nlm.nih.gov/pubmed/11818558 PubMed 12198182 http://www.ncbi.nlm.nih.gov/pubmed/12198182 PubMed 12571359 http://www.ncbi.nlm.nih.gov/pubmed/12571359 PubMed 12706830 http://www.ncbi.nlm.nih.gov/pubmed/12706830 PubMed 15469281 http://www.ncbi.nlm.nih.gov/pubmed/15469281 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19569147 http://www.ncbi.nlm.nih.gov/pubmed/19569147 PubMed 20080550 http://www.ncbi.nlm.nih.gov/pubmed/20080550 PubMed 2011499 http://www.ncbi.nlm.nih.gov/pubmed/2011499 PubMed 22137895 http://www.ncbi.nlm.nih.gov/pubmed/22137895 PubMed 8432714 http://www.ncbi.nlm.nih.gov/pubmed/8432714 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414570 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414570 RefSeq WP_001166395 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001166395 SMR P62623 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P62623 STRING 511145.b0029 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0029&targetmode=cogs STRING COG0761 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0761&targetmode=cogs TIGRFAMs TIGR00216 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00216 UniProtKB ISPH_ECOLI http://www.uniprot.org/uniprot/ISPH_ECOLI UniProtKB-AC P62623 http://www.uniprot.org/uniprot/P62623 charge swissprot:ISPH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ISPH_ECOLI eggNOG COG0761 http://eggnogapi.embl.de/nog_data/html/tree/COG0761 eggNOG ENOG4105C48 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C48 epestfind swissprot:ISPH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ISPH_ECOLI garnier swissprot:ISPH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ISPH_ECOLI helixturnhelix swissprot:ISPH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ISPH_ECOLI hmoment swissprot:ISPH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ISPH_ECOLI iep swissprot:ISPH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ISPH_ECOLI inforesidue swissprot:ISPH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ISPH_ECOLI octanol swissprot:ISPH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ISPH_ECOLI pepcoil swissprot:ISPH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ISPH_ECOLI pepdigest swissprot:ISPH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ISPH_ECOLI pepinfo swissprot:ISPH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ISPH_ECOLI pepnet swissprot:ISPH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ISPH_ECOLI pepstats swissprot:ISPH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ISPH_ECOLI pepwheel swissprot:ISPH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ISPH_ECOLI pepwindow swissprot:ISPH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ISPH_ECOLI sigcleave swissprot:ISPH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ISPH_ECOLI ## Database ID URL or Descriptions # BRENDA 1.14.99.B5 2026 # BioGrid 4262345 372 # COFACTOR Name=FAD; Xref=ChEBI:CHEBI 57692; Evidence={ECO:0000250}; # DISRUPTION PHENOTYPE UBIH_ECOLI Cells lacking this gene are photosensitive and are not able to grow with a nonfermentable source of carbon. They also fail to produce ubiquinone, and accumulate 2- octaprenylphenol and 2-octaprenyl-6-methoxyphenol. {ECO 0000269|PubMed 1339425, ECO 0000269|PubMed 4572721}. # EcoGene EG11324 ubiH # FUNCTION UBIH_ECOLI Is likely an oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinol. {ECO 0000269|PubMed 4572721}. # GO_function GO:0004497 monooxygenase activity; IBA:GO_Central. # GO_function GO:0008681 2-octaprenyl-6-methoxyphenol hydroxylase activity; IMP:EcoCyc. # GO_function GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; IEA:InterPro. # GO_function GO:0071949 FAD binding; IEA:InterPro. # GO_process GO:0006744 ubiquinone biosynthetic process; IMP:EcoCyc. # GO_process GO:0006979 response to oxidative stress; IMP:EcoliWiki. # GO_process GO:0009416 response to light stimulus; IMP:EcoliWiki. # GO_process GO:0044550 secondary metabolite biosynthetic process; IBA:GO_Central. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0019748 secondary metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.50.50.60 -; 2. # IntAct P25534 13 # InterPro IPR002938 FAD-bd # InterPro IPR010971 UbiH/COQ6 # InterPro IPR011295 UbiH # InterPro IPR018168 Ubi_Hdrlase_CS # InterPro IPR023753 FAD/NAD-binding_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00130 Ubiquinone and other terpenoid-quinone biosynthesis # Organism UBIH_ECOLI Escherichia coli (strain K12) # PATHWAY UBIH_ECOLI Cofactor biosynthesis; ubiquinone biosynthesis. # PATRIC 32121228 VBIEscCol129921_3002 # PIR C65075 C65075 # PROSITE PS01304 UBIH # Pfam PF01494 FAD_binding_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UBIH_ECOLI 2-octaprenyl-6-methoxyphenol hydroxylase # RefSeq NP_417383 NC_000913.3 # RefSeq WP_000111195 NZ_LN832404.1 # SIMILARITY Belongs to the UbiH/COQ6 family. {ECO 0000305}. # SUPFAM SSF51905 SSF51905; 2 # TIGRFAMs TIGR01984 UbiH # TIGRFAMs TIGR01988 Ubi-OHases # eggNOG COG0654 LUCA # eggNOG ENOG4105D0A Bacteria BLAST swissprot:UBIH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UBIH_ECOLI BioCyc ECOL316407:JW2875-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2875-MONOMER BioCyc EcoCyc:OCTAPRENYL-METHOXYPHENOL-OH-MONOMER http://biocyc.org/getid?id=EcoCyc:OCTAPRENYL-METHOXYPHENOL-OH-MONOMER BioCyc MetaCyc:OCTAPRENYL-METHOXYPHENOL-OH-MONOMER http://biocyc.org/getid?id=MetaCyc:OCTAPRENYL-METHOXYPHENOL-OH-MONOMER COG COG0654 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0654 DIP DIP-11071N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11071N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.14.13.- http://www.genome.jp/dbget-bin/www_bget?EC:1.14.13.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D90281 http://www.ebi.ac.uk/ena/data/view/D90281 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 ENZYME 1.14.13.- http://enzyme.expasy.org/EC/1.14.13.- EchoBASE EB1300 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1300 EcoGene EG11324 http://www.ecogene.org/geneInfo.php?eg_id=EG11324 EnsemblBacteria AAC75945 http://www.ensemblgenomes.org/id/AAC75945 EnsemblBacteria AAC75945 http://www.ensemblgenomes.org/id/AAC75945 EnsemblBacteria BAE76972 http://www.ensemblgenomes.org/id/BAE76972 EnsemblBacteria BAE76972 http://www.ensemblgenomes.org/id/BAE76972 EnsemblBacteria BAE76972 http://www.ensemblgenomes.org/id/BAE76972 EnsemblBacteria b2907 http://www.ensemblgenomes.org/id/b2907 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004497 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004497 GO_function GO:0008681 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008681 GO_function GO:0016709 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016709 GO_function GO:0071949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071949 GO_process GO:0006744 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006744 GO_process GO:0006979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979 GO_process GO:0009416 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009416 GO_process GO:0044550 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044550 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0019748 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019748 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 GeneID 947388 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947388 HOGENOM HOG000255770 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000255770&db=HOGENOM6 InParanoid P25534 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P25534 IntAct P25534 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P25534* IntEnz 1.14.13 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.14.13 InterPro IPR002938 http://www.ebi.ac.uk/interpro/entry/IPR002938 InterPro IPR010971 http://www.ebi.ac.uk/interpro/entry/IPR010971 InterPro IPR011295 http://www.ebi.ac.uk/interpro/entry/IPR011295 InterPro IPR018168 http://www.ebi.ac.uk/interpro/entry/IPR018168 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2875 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2875 KEGG_Gene eco:b2907 http://www.genome.jp/dbget-bin/www_bget?eco:b2907 KEGG_Orthology KO:K03185 http://www.genome.jp/dbget-bin/www_bget?KO:K03185 KEGG_Pathway ko00130 http://www.genome.jp/kegg-bin/show_pathway?ko00130 KEGG_Reaction rn:R04989 http://www.genome.jp/dbget-bin/www_bget?rn:R04989 KEGG_Reaction rn:R08773 http://www.genome.jp/dbget-bin/www_bget?rn:R08773 MINT MINT-1289084 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1289084 OMA YVVRYGS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YVVRYGS PROSITE PS01304 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01304 PSORT swissprot:UBIH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UBIH_ECOLI PSORT-B swissprot:UBIH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UBIH_ECOLI PSORT2 swissprot:UBIH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UBIH_ECOLI Pfam PF01494 http://pfam.xfam.org/family/PF01494 Phobius swissprot:UBIH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UBIH_ECOLI PhylomeDB P25534 http://phylomedb.org/?seqid=P25534 ProteinModelPortal P25534 http://www.proteinmodelportal.org/query/uniprot/P25534 PubMed 1339425 http://www.ncbi.nlm.nih.gov/pubmed/1339425 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 4572721 http://www.ncbi.nlm.nih.gov/pubmed/4572721 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417383 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417383 RefSeq WP_000111195 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000111195 SMR P25534 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P25534 STRING 511145.b2907 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2907&targetmode=cogs STRING COG0654 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0654&targetmode=cogs SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 TIGRFAMs TIGR01984 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01984 TIGRFAMs TIGR01988 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01988 UniProtKB UBIH_ECOLI http://www.uniprot.org/uniprot/UBIH_ECOLI UniProtKB-AC P25534 http://www.uniprot.org/uniprot/P25534 charge swissprot:UBIH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UBIH_ECOLI eggNOG COG0654 http://eggnogapi.embl.de/nog_data/html/tree/COG0654 eggNOG ENOG4105D0A http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D0A epestfind swissprot:UBIH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UBIH_ECOLI garnier swissprot:UBIH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UBIH_ECOLI helixturnhelix swissprot:UBIH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UBIH_ECOLI hmoment swissprot:UBIH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UBIH_ECOLI iep swissprot:UBIH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UBIH_ECOLI inforesidue swissprot:UBIH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UBIH_ECOLI octanol swissprot:UBIH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UBIH_ECOLI pepcoil swissprot:UBIH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UBIH_ECOLI pepdigest swissprot:UBIH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UBIH_ECOLI pepinfo swissprot:UBIH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UBIH_ECOLI pepnet swissprot:UBIH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UBIH_ECOLI pepstats swissprot:UBIH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UBIH_ECOLI pepwheel swissprot:UBIH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UBIH_ECOLI pepwindow swissprot:UBIH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UBIH_ECOLI sigcleave swissprot:UBIH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UBIH_ECOLI ## Database ID URL or Descriptions # BioGrid 4259971 2 # CDD cd06261 TM_PBP2 # EcoGene EG10388 glnP # FUNCTION GLNP_ECOLI Part of the binding-protein-dependent transport system for glutamine; probably responsible for the translocation of the substrate across the membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015171 amino acid transmembrane transporter activity; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # Gene3D 1.10.3720.10 -; 1. # INDUCTION GLNP_ECOLI By lack of glutamine. # InterPro IPR000515 MetI-like # InterPro IPR010065 AA_ABC_transptr_permease_3TM # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00227 Glutamine transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism GLNP_ECOLI Escherichia coli (strain K12) # PATRIC 32116823 VBIEscCol129921_0837 # PIR S03182 QRECGP # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLNP_ECOLI Glutamine transport system permease protein GlnP # RefSeq NP_415331 NC_000913.3 # RefSeq WP_001159065 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION GLNP_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF161098 SSF161098 # TCDB 3.A.1.3 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR01726 HEQRo_perm_3TM # eggNOG COG0765 LUCA # eggNOG ENOG4105E5Q Bacteria BLAST swissprot:GLNP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLNP_ECOLI BioCyc ECOL316407:JW0795-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0795-MONOMER BioCyc EcoCyc:GLNP-MONOMER http://biocyc.org/getid?id=EcoCyc:GLNP-MONOMER BioCyc MetaCyc:GLNP-MONOMER http://biocyc.org/getid?id=MetaCyc:GLNP-MONOMER COG COG0765 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0765 DIP DIP-47993N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47993N DOI 10.1007/BF00430437 http://dx.doi.org/10.1007/BF00430437 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X14180 http://www.ebi.ac.uk/ena/data/view/X14180 EchoBASE EB0383 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0383 EcoGene EG10388 http://www.ecogene.org/geneInfo.php?eg_id=EG10388 EnsemblBacteria AAC73897 http://www.ensemblgenomes.org/id/AAC73897 EnsemblBacteria AAC73897 http://www.ensemblgenomes.org/id/AAC73897 EnsemblBacteria BAA35482 http://www.ensemblgenomes.org/id/BAA35482 EnsemblBacteria BAA35482 http://www.ensemblgenomes.org/id/BAA35482 EnsemblBacteria BAA35482 http://www.ensemblgenomes.org/id/BAA35482 EnsemblBacteria b0810 http://www.ensemblgenomes.org/id/b0810 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015171 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 945621 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945621 HOGENOM HOG000267552 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267552&db=HOGENOM6 InParanoid P0AEQ6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEQ6 InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 InterPro IPR010065 http://www.ebi.ac.uk/interpro/entry/IPR010065 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0795 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0795 KEGG_Gene eco:b0810 http://www.genome.jp/dbget-bin/www_bget?eco:b0810 KEGG_Orthology KO:K10037 http://www.genome.jp/dbget-bin/www_bget?KO:K10037 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA TIRHVIM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TIRHVIM PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:GLNP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLNP_ECOLI PSORT-B swissprot:GLNP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLNP_ECOLI PSORT2 swissprot:GLNP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLNP_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Phobius swissprot:GLNP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLNP_ECOLI PhylomeDB P0AEQ6 http://phylomedb.org/?seqid=P0AEQ6 ProteinModelPortal P0AEQ6 http://www.proteinmodelportal.org/query/uniprot/P0AEQ6 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3027504 http://www.ncbi.nlm.nih.gov/pubmed/3027504 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415331 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415331 RefSeq WP_001159065 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001159065 SMR P0AEQ6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEQ6 STRING 511145.b0810 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0810&targetmode=cogs STRING COG0765 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0765&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.3 http://www.tcdb.org/search/result.php?tc=3.A.1.3 TIGRFAMs TIGR01726 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01726 UniProtKB GLNP_ECOLI http://www.uniprot.org/uniprot/GLNP_ECOLI UniProtKB-AC P0AEQ6 http://www.uniprot.org/uniprot/P0AEQ6 charge swissprot:GLNP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLNP_ECOLI eggNOG COG0765 http://eggnogapi.embl.de/nog_data/html/tree/COG0765 eggNOG ENOG4105E5Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E5Q epestfind swissprot:GLNP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLNP_ECOLI garnier swissprot:GLNP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLNP_ECOLI helixturnhelix swissprot:GLNP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLNP_ECOLI hmoment swissprot:GLNP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLNP_ECOLI iep swissprot:GLNP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLNP_ECOLI inforesidue swissprot:GLNP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLNP_ECOLI octanol swissprot:GLNP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLNP_ECOLI pepcoil swissprot:GLNP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLNP_ECOLI pepdigest swissprot:GLNP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLNP_ECOLI pepinfo swissprot:GLNP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLNP_ECOLI pepnet swissprot:GLNP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLNP_ECOLI pepstats swissprot:GLNP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLNP_ECOLI pepwheel swissprot:GLNP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLNP_ECOLI pepwindow swissprot:GLNP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLNP_ECOLI sigcleave swissprot:GLNP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLNP_ECOLI ## Database ID URL or Descriptions # AltName Enoylpyruvate transferase {ECO:0000255|HAMAP-Rule MF_00111} # AltName UDP-N-acetylglucosamine enolpyruvyl transferase {ECO:0000255|HAMAP-Rule MF_00111} # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=15 uM for UDP-N-acetylglucosamine {ECO 0000269|PubMed:21445328}; # BRENDA 2.5.1 2026 # BioGrid 4262438 633 # CATALYTIC ACTIVITY MURA_ECOLI Phosphoenolpyruvate + UDP-N-acetyl-alpha-D- glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha- D-glucosamine. {ECO 0000255|HAMAP-Rule MF_00111, ECO 0000269|PubMed 1512209, ECO 0000269|PubMed 20392080}. # CDD cd01555 UdpNAET # DrugBank DB00828 Fosfomycin # ENZYME REGULATION MURA_ECOLI Competitively inhibited by UDP-N- acetylglucosamine 3'-phosphate, with a Ki of 7 uM (PubMed 21445328). In vitro inhibited by covalent binding of fosfomycin and the fungal product terreic acid in the presence of substrate UDP-N-acetylglucosamine, with an inactivation rate constant of 102 M(-1)s(-1) for terreic acid (PubMed 20392080). {ECO 0000269|PubMed 20392080, ECO 0000269|PubMed 21445328}. # EcoGene EG11358 murA # FUNCTION MURA_ECOLI Cell wall formation (PubMed 1512209). Adds enolpyruvyl to UDP-N-acetylglucosamine (PubMed 1512209, PubMed 20392080). Target for the antibiotic fosfomycin. {ECO 0000269|PubMed 1512209, ECO 0000269|PubMed 20392080}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008760 UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity; IDA:EcoCyc. # GO_process GO:0007049 cell cycle; IEA:UniProtKB-KW. # GO_process GO:0008360 regulation of cell shape; IEA:UniProtKB-KW. # GO_process GO:0009252 peptidoglycan biosynthetic process; IMP:EcoCyc. # GO_process GO:0019277 UDP-N-acetylgalactosamine biosynthetic process; IEA:InterPro. # GO_process GO:0051301 cell division; IEA:UniProtKB-KW. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups # GOslim_process GO:0007049 cell cycle # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0051301 cell division # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 3.65.10.10 -; 2. # HAMAP MF_00111 MurA # IntAct P0A749 23 # InterPro IPR001986 Enolpyruvate_Tfrase_dom # InterPro IPR005750 UDP_GlcNAc_COvinyl_MurA # InterPro IPR013792 RNA3'P_cycl/enolpyr_Trfase_a/b # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00520 Amino sugar and nucleotide sugar metabolism # KEGG_Pathway ko00550 Peptidoglycan biosynthesis # Organism MURA_ECOLI Escherichia coli (strain K12) # PATHWAY MURA_ECOLI Cell wall biogenesis; peptidoglycan biosynthesis. {ECO 0000255|HAMAP-Rule MF_00111, ECO 0000269|PubMed 1512209}. # PATRIC 32121798 VBIEscCol129921_3283 # PDB 1A2N X-ray; 2.80 A; A=1-419 # PDB 1UAE X-ray; 1.80 A; A=1-419 # PDB 2Z2C X-ray; 2.05 A; A/B/C/D=1-419 # PDB 3ISS X-ray; 2.50 A; A/B/C/D/E/F/G/H/I/J/K/L=1-418 # PDB 3KQJ X-ray; 1.70 A; A=1-419 # PDB 3KR6 X-ray; 1.70 A; A=1-419 # PDB 3SWD X-ray; 2.50 A; A/B/C/D/E/F/G/H/I/J/K/L=1-418 # PIR A44917 A44917 # Pfam PF00275 EPSP_synthase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UDP-N-acetylglucosamine 1-carboxyvinyltransferase {ECO:0000255|HAMAP-Rule MF_00111} # RefSeq NP_417656 NC_000913.3 # RefSeq WP_000357259 NZ_LN832404.1 # SIMILARITY Belongs to the EPSP synthase family. MurA subfamily. {ECO:0000255|HAMAP-Rule MF_00111}. # SUBCELLULAR LOCATION MURA_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00111, ECO 0000305}. # SUPFAM SSF55205 SSF55205 # TIGRFAMs TIGR01072 murA # eggNOG COG0766 LUCA # eggNOG ENOG4105CDF Bacteria BLAST swissprot:MURA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MURA_ECOLI BioCyc ECOL316407:JW3156-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3156-MONOMER BioCyc EcoCyc:UDPNACETYLGLUCOSAMENOLPYRTRANS-MONOMER http://biocyc.org/getid?id=EcoCyc:UDPNACETYLGLUCOSAMENOLPYRTRANS-MONOMER BioCyc MetaCyc:UDPNACETYLGLUCOSAMENOLPYRTRANS-MONOMER http://biocyc.org/getid?id=MetaCyc:UDPNACETYLGLUCOSAMENOLPYRTRANS-MONOMER COG COG0766 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0766 DIP DIP-48060N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48060N DOI 10.1016/S0969-2126(96)00153-0 http://dx.doi.org/10.1016/S0969-2126(96)00153-0 DOI 10.1021/bi100365b http://dx.doi.org/10.1021/bi100365b DOI 10.1021/bi9722608 http://dx.doi.org/10.1021/bi9722608 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M112.342725 http://dx.doi.org/10.1074/jbc.M112.342725 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pbio.1001033 http://dx.doi.org/10.1371/journal.pbio.1001033 DrugBank DB00828 http://www.drugbank.ca/drugs/DB00828 EC_number EC:2.5.1.7 {ECO:0000255|HAMAP-Rule:MF_00111} http://www.genome.jp/dbget-bin/www_bget?EC:2.5.1.7 {ECO:0000255|HAMAP-Rule:MF_00111} EMBL AB028039 http://www.ebi.ac.uk/ena/data/view/AB028039 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M92358 http://www.ebi.ac.uk/ena/data/view/M92358 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 2.5.1.7 {ECO:0000255|HAMAP-Rule:MF_00111} http://enzyme.expasy.org/EC/2.5.1.7 {ECO:0000255|HAMAP-Rule:MF_00111} EchoBASE EB1333 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1333 EcoGene EG11358 http://www.ecogene.org/geneInfo.php?eg_id=EG11358 EnsemblBacteria AAC76221 http://www.ensemblgenomes.org/id/AAC76221 EnsemblBacteria AAC76221 http://www.ensemblgenomes.org/id/AAC76221 EnsemblBacteria BAE77233 http://www.ensemblgenomes.org/id/BAE77233 EnsemblBacteria BAE77233 http://www.ensemblgenomes.org/id/BAE77233 EnsemblBacteria BAE77233 http://www.ensemblgenomes.org/id/BAE77233 EnsemblBacteria b3189 http://www.ensemblgenomes.org/id/b3189 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008760 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008760 GO_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0009252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009252 GO_process GO:0019277 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019277 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016765 GOslim_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 3.65.10.10 http://www.cathdb.info/version/latest/superfamily/3.65.10.10 GeneID 947703 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947703 HAMAP MF_00111 http://hamap.expasy.org/unirule/MF_00111 HOGENOM HOG000075602 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000075602&db=HOGENOM6 InParanoid P0A749 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A749 IntAct P0A749 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A749* IntEnz 2.5.1.7 {ECO:0000255|HAMAP-Rule:MF_00111} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.5.1.7 {ECO:0000255|HAMAP-Rule:MF_00111} InterPro IPR001986 http://www.ebi.ac.uk/interpro/entry/IPR001986 InterPro IPR005750 http://www.ebi.ac.uk/interpro/entry/IPR005750 InterPro IPR013792 http://www.ebi.ac.uk/interpro/entry/IPR013792 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3156 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3156 KEGG_Gene eco:b3189 http://www.genome.jp/dbget-bin/www_bget?eco:b3189 KEGG_Orthology KO:K00790 http://www.genome.jp/dbget-bin/www_bget?KO:K00790 KEGG_Pathway ko00520 http://www.genome.jp/kegg-bin/show_pathway?ko00520 KEGG_Pathway ko00550 http://www.genome.jp/kegg-bin/show_pathway?ko00550 KEGG_Reaction rn:R00660 http://www.genome.jp/dbget-bin/www_bget?rn:R00660 MINT MINT-1224932 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1224932 OMA IRTAPHP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IRTAPHP PDB 1A2N http://www.ebi.ac.uk/pdbe-srv/view/entry/1A2N PDB 1UAE http://www.ebi.ac.uk/pdbe-srv/view/entry/1UAE PDB 2Z2C http://www.ebi.ac.uk/pdbe-srv/view/entry/2Z2C PDB 3ISS http://www.ebi.ac.uk/pdbe-srv/view/entry/3ISS PDB 3KQJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3KQJ PDB 3KR6 http://www.ebi.ac.uk/pdbe-srv/view/entry/3KR6 PDB 3SWD http://www.ebi.ac.uk/pdbe-srv/view/entry/3SWD PDBsum 1A2N http://www.ebi.ac.uk/pdbsum/1A2N PDBsum 1UAE http://www.ebi.ac.uk/pdbsum/1UAE PDBsum 2Z2C http://www.ebi.ac.uk/pdbsum/2Z2C PDBsum 3ISS http://www.ebi.ac.uk/pdbsum/3ISS PDBsum 3KQJ http://www.ebi.ac.uk/pdbsum/3KQJ PDBsum 3KR6 http://www.ebi.ac.uk/pdbsum/3KR6 PDBsum 3SWD http://www.ebi.ac.uk/pdbsum/3SWD PSORT swissprot:MURA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MURA_ECOLI PSORT-B swissprot:MURA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MURA_ECOLI PSORT2 swissprot:MURA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MURA_ECOLI Pfam PF00275 http://pfam.xfam.org/family/PF00275 Phobius swissprot:MURA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MURA_ECOLI PhylomeDB P0A749 http://phylomedb.org/?seqid=P0A749 ProteinModelPortal P0A749 http://www.proteinmodelportal.org/query/uniprot/P0A749 PubMed 10103182 http://www.ncbi.nlm.nih.gov/pubmed/10103182 PubMed 1512209 http://www.ncbi.nlm.nih.gov/pubmed/1512209 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20392080 http://www.ncbi.nlm.nih.gov/pubmed/20392080 PubMed 21445328 http://www.ncbi.nlm.nih.gov/pubmed/21445328 PubMed 22378791 http://www.ncbi.nlm.nih.gov/pubmed/22378791 PubMed 8994972 http://www.ncbi.nlm.nih.gov/pubmed/8994972 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9485407 http://www.ncbi.nlm.nih.gov/pubmed/9485407 RefSeq NP_417656 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417656 RefSeq WP_000357259 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000357259 SMR P0A749 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A749 STRING 511145.b3189 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3189&targetmode=cogs STRING COG0766 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0766&targetmode=cogs SUPFAM SSF55205 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55205 TIGRFAMs TIGR01072 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01072 UniProtKB MURA_ECOLI http://www.uniprot.org/uniprot/MURA_ECOLI UniProtKB-AC P0A749 http://www.uniprot.org/uniprot/P0A749 charge swissprot:MURA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MURA_ECOLI eggNOG COG0766 http://eggnogapi.embl.de/nog_data/html/tree/COG0766 eggNOG ENOG4105CDF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CDF epestfind swissprot:MURA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MURA_ECOLI garnier swissprot:MURA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MURA_ECOLI helixturnhelix swissprot:MURA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MURA_ECOLI hmoment swissprot:MURA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MURA_ECOLI iep swissprot:MURA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MURA_ECOLI inforesidue swissprot:MURA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MURA_ECOLI octanol swissprot:MURA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MURA_ECOLI pepcoil swissprot:MURA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MURA_ECOLI pepdigest swissprot:MURA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MURA_ECOLI pepinfo swissprot:MURA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MURA_ECOLI pepnet swissprot:MURA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MURA_ECOLI pepstats swissprot:MURA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MURA_ECOLI pepwheel swissprot:MURA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MURA_ECOLI pepwindow swissprot:MURA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MURA_ECOLI sigcleave swissprot:MURA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MURA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261320 404 # EcoGene EG10156 clpA # FUNCTION CLPA_ECOLI ATP-dependent specificity component of the ClpAP protease. It directs the protease to specific substrates. It has unfoldase activity. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004176 ATP-dependent peptidase activity; IDA:CACAO. # GO_function GO:0005524 ATP binding; IDA:EcoCyc. # GO_function GO:0016887 ATPase activity; IDA:EcoCyc. # GO_process GO:0006979 response to oxidative stress; IMP:EcoCyc. # GO_process GO:0043335 protein unfolding; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # Gene3D 1.10.1780.10 -; 1. # Gene3D 3.40.50.300 -; 2. # INTERACTION CLPA_ECOLI P0A6G7 clpP; NbExp=3; IntAct=EBI-546140, EBI-370625; P0A8Q6 clpS; NbExp=10; IntAct=EBI-546140, EBI-561456; P68646 fixX; NbExp=2; IntAct=EBI-546140, EBI-1113234; # IntAct P0ABH9 75 # InterPro IPR001270 ClpA/B # InterPro IPR003593 AAA+_ATPase # InterPro IPR003959 ATPase_AAA_core # InterPro IPR004176 Clp_N # InterPro IPR013461 ClpA # InterPro IPR018368 ClpA/B_CS1 # InterPro IPR019489 Clp_ATPase_C # InterPro IPR027417 P-loop_NTPase # InterPro IPR028299 ClpA/B_CS2 # KEGG_Brite ko03110 Chaperones and folding catalysts # Organism CLPA_ECOLI Escherichia coli (strain K12) # PATRIC 32116973 VBIEscCol129921_0912 # PDB 1K6K X-ray; 1.80 A; A=1-143 # PDB 1KSF X-ray; 2.60 A; X=1-758 # PDB 1LZW X-ray; 2.50 A; B=1-146 # PDB 1MBU X-ray; 2.30 A; A/B=1-142 # PDB 1MBV X-ray; 3.30 A; A=1-142 # PDB 1MBX X-ray; 2.25 A; A/B=1-142 # PDB 1MG9 X-ray; 2.30 A; B=1-146 # PDB 1R6B X-ray; 2.25 A; X=1-758 # PDB 1R6C X-ray; 2.15 A; X=1-143 # PDB 1R6O X-ray; 2.25 A; A/B=1-143 # PDB 1R6Q X-ray; 2.35 A; A/B=1-143 # PIR B64827 SUECCA # PRINTS PR00300 CLPPROTEASEA # PROSITE PS00870 CLPAB_1 # PROSITE PS00871 CLPAB_2 # Pfam PF00004 AAA # Pfam PF02861 Clp_N # Pfam PF07724 AAA_2 # Pfam PF10431 ClpB_D2-small # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CLPA_ECOLI ATP-dependent Clp protease ATP-binding subunit ClpA # RefSeq NP_415403 NC_000913.3 # RefSeq WP_000934041 NZ_LN832404.1 # SIMILARITY Belongs to the ClpA/ClpB family. {ECO 0000305}. # SMART SM00382 AAA; 2 # SMART SM01086 ClpB_D2-small # SUBUNIT CLPA_ECOLI Component of the ClpAP complex composed of six ClpA subunits assembled into a hexameric ring in the presence of ATP, and fourteen ClpP subunits arranged in two heptameric rings. Binds to ClpS. {ECO 0000269|PubMed 12235156, ECO 0000269|PubMed 12426582}. # SUPFAM SSF52540 SSF52540; 2 # SUPFAM SSF81923 SSF81923 # TIGRFAMs TIGR02639 ClpA # eggNOG COG0542 LUCA # eggNOG ENOG4105C2Z Bacteria BLAST swissprot:CLPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CLPA_ECOLI BioCyc ECOL316407:JW0866-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0866-MONOMER BioCyc EcoCyc:EG10156-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10156-MONOMER BioCyc MetaCyc:EG10156-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10156-MONOMER COG COG0542 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0542 DIP DIP-35409N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35409N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb869 http://dx.doi.org/10.1038/nsb869 DOI 10.1073/pnas.87.9.3513 http://dx.doi.org/10.1073/pnas.87.9.3513 DOI 10.1074/jbc.M207796200 http://dx.doi.org/10.1074/jbc.M207796200 DOI 10.1074/jbc.M208104200 http://dx.doi.org/10.1074/jbc.M208104200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M23220 http://www.ebi.ac.uk/ena/data/view/M23220 EMBL M31045 http://www.ebi.ac.uk/ena/data/view/M31045 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0154 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0154 EcoGene EG10156 http://www.ecogene.org/geneInfo.php?eg_id=EG10156 EnsemblBacteria AAC73969 http://www.ensemblgenomes.org/id/AAC73969 EnsemblBacteria AAC73969 http://www.ensemblgenomes.org/id/AAC73969 EnsemblBacteria BAA35601 http://www.ensemblgenomes.org/id/BAA35601 EnsemblBacteria BAA35601 http://www.ensemblgenomes.org/id/BAA35601 EnsemblBacteria BAA35601 http://www.ensemblgenomes.org/id/BAA35601 EnsemblBacteria b0882 http://www.ensemblgenomes.org/id/b0882 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004176 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004176 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_process GO:0006979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979 GO_process GO:0043335 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043335 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.10.1780.10 http://www.cathdb.info/version/latest/superfamily/1.10.1780.10 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945764 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945764 HOGENOM HOG000218210 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218210&db=HOGENOM6 InParanoid P0ABH9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABH9 IntAct P0ABH9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABH9* InterPro IPR001270 http://www.ebi.ac.uk/interpro/entry/IPR001270 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR003959 http://www.ebi.ac.uk/interpro/entry/IPR003959 InterPro IPR004176 http://www.ebi.ac.uk/interpro/entry/IPR004176 InterPro IPR013461 http://www.ebi.ac.uk/interpro/entry/IPR013461 InterPro IPR018368 http://www.ebi.ac.uk/interpro/entry/IPR018368 InterPro IPR019489 http://www.ebi.ac.uk/interpro/entry/IPR019489 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR028299 http://www.ebi.ac.uk/interpro/entry/IPR028299 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW0866 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0866 KEGG_Gene eco:b0882 http://www.genome.jp/dbget-bin/www_bget?eco:b0882 KEGG_Orthology KO:K03694 http://www.genome.jp/dbget-bin/www_bget?KO:K03694 OMA DHSPDAM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DHSPDAM PDB 1K6K http://www.ebi.ac.uk/pdbe-srv/view/entry/1K6K PDB 1KSF http://www.ebi.ac.uk/pdbe-srv/view/entry/1KSF PDB 1LZW http://www.ebi.ac.uk/pdbe-srv/view/entry/1LZW PDB 1MBU http://www.ebi.ac.uk/pdbe-srv/view/entry/1MBU PDB 1MBV http://www.ebi.ac.uk/pdbe-srv/view/entry/1MBV PDB 1MBX http://www.ebi.ac.uk/pdbe-srv/view/entry/1MBX PDB 1MG9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1MG9 PDB 1R6B http://www.ebi.ac.uk/pdbe-srv/view/entry/1R6B PDB 1R6C http://www.ebi.ac.uk/pdbe-srv/view/entry/1R6C PDB 1R6O http://www.ebi.ac.uk/pdbe-srv/view/entry/1R6O PDB 1R6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/1R6Q PDBsum 1K6K http://www.ebi.ac.uk/pdbsum/1K6K PDBsum 1KSF http://www.ebi.ac.uk/pdbsum/1KSF PDBsum 1LZW http://www.ebi.ac.uk/pdbsum/1LZW PDBsum 1MBU http://www.ebi.ac.uk/pdbsum/1MBU PDBsum 1MBV http://www.ebi.ac.uk/pdbsum/1MBV PDBsum 1MBX http://www.ebi.ac.uk/pdbsum/1MBX PDBsum 1MG9 http://www.ebi.ac.uk/pdbsum/1MG9 PDBsum 1R6B http://www.ebi.ac.uk/pdbsum/1R6B PDBsum 1R6C http://www.ebi.ac.uk/pdbsum/1R6C PDBsum 1R6O http://www.ebi.ac.uk/pdbsum/1R6O PDBsum 1R6Q http://www.ebi.ac.uk/pdbsum/1R6Q PRINTS PR00300 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00300 PROSITE PS00870 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00870 PROSITE PS00871 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00871 PSORT swissprot:CLPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CLPA_ECOLI PSORT-B swissprot:CLPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CLPA_ECOLI PSORT2 swissprot:CLPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CLPA_ECOLI Pfam PF00004 http://pfam.xfam.org/family/PF00004 Pfam PF02861 http://pfam.xfam.org/family/PF02861 Pfam PF07724 http://pfam.xfam.org/family/PF07724 Pfam PF10431 http://pfam.xfam.org/family/PF10431 Phobius swissprot:CLPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CLPA_ECOLI PhylomeDB P0ABH9 http://phylomedb.org/?seqid=P0ABH9 ProteinModelPortal P0ABH9 http://www.proteinmodelportal.org/query/uniprot/P0ABH9 PubMed 12205096 http://www.ncbi.nlm.nih.gov/pubmed/12205096 PubMed 12235156 http://www.ncbi.nlm.nih.gov/pubmed/12235156 PubMed 12426582 http://www.ncbi.nlm.nih.gov/pubmed/12426582 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1909328 http://www.ncbi.nlm.nih.gov/pubmed/1909328 PubMed 2185473 http://www.ncbi.nlm.nih.gov/pubmed/2185473 PubMed 2186030 http://www.ncbi.nlm.nih.gov/pubmed/2186030 PubMed 3049606 http://www.ncbi.nlm.nih.gov/pubmed/3049606 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415403 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415403 RefSeq WP_000934041 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000934041 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMART SM01086 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01086 SMR P0ABH9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABH9 STRING 511145.b0882 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0882&targetmode=cogs STRING COG0542 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0542&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SUPFAM SSF81923 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81923 TIGRFAMs TIGR02639 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02639 UniProtKB CLPA_ECOLI http://www.uniprot.org/uniprot/CLPA_ECOLI UniProtKB-AC P0ABH9 http://www.uniprot.org/uniprot/P0ABH9 charge swissprot:CLPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CLPA_ECOLI eggNOG COG0542 http://eggnogapi.embl.de/nog_data/html/tree/COG0542 eggNOG ENOG4105C2Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C2Z epestfind swissprot:CLPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CLPA_ECOLI garnier swissprot:CLPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CLPA_ECOLI helixturnhelix swissprot:CLPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CLPA_ECOLI hmoment swissprot:CLPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CLPA_ECOLI iep swissprot:CLPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CLPA_ECOLI inforesidue swissprot:CLPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CLPA_ECOLI octanol swissprot:CLPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CLPA_ECOLI pepcoil swissprot:CLPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CLPA_ECOLI pepdigest swissprot:CLPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CLPA_ECOLI pepinfo swissprot:CLPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CLPA_ECOLI pepnet swissprot:CLPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CLPA_ECOLI pepstats swissprot:CLPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CLPA_ECOLI pepwheel swissprot:CLPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CLPA_ECOLI pepwindow swissprot:CLPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CLPA_ECOLI sigcleave swissprot:CLPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CLPA_ECOLI ## Database ID URL or Descriptions # AltName ABC phosphate transporter {ECO:0000255|HAMAP-Rule MF_01702} # AltName Phosphate-transporting ATPase {ECO:0000255|HAMAP-Rule MF_01702} # BioGrid 4262135 10 # CATALYTIC ACTIVITY ATP + H(2)O + phosphate(Out) = ADP + phosphate + phosphate(In). {ECO:0000255|HAMAP-Rule MF_01702}. # CDD cd03260 ABC_PstB_phosphate_transporter # EcoGene EG10783 pstB # FUNCTION PSTB_ECOLI Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IEA:UniProtKB-HAMAP. # GO_function GO:0005315 inorganic phosphate transmembrane transporter activity; IEA:InterPro. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0015415 ATPase-coupled phosphate ion transmembrane transporter activity; IDA:EcoCyc. # GO_process GO:0006817 phosphate ion transport; IDA:EcoCyc. # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # Gene3D 3.40.50.300 -; 1. # IntAct P0AAH0 26 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR005670 Phosp_transpt1 # InterPro IPR015850 ABC_transpr_PstB # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00222 Phosphate transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism PSTB_ECOLI Escherichia coli (strain K12) # PATRIC 32122947 VBIEscCol129921_3849 # PIR A30382 BVECZB # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # PROSITE PS51238 PSTB # Pfam PF00005 ABC_tran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Phosphate import ATP-binding protein PstB {ECO:0000255|HAMAP-Rule MF_01702} # RefSeq NP_418181 NC_000913.3 # RefSeq WP_000063125 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. {ECO:0000255|HAMAP-Rule MF_01702}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|HAMAP- Rule MF_01702}. # SMART SM00382 AAA # SUBCELLULAR LOCATION PSTB_ECOLI Cell inner membrane; Peripheral membrane protein. # SUBUNIT The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute- binding protein (PstS). {ECO:0000255|HAMAP-Rule MF_01702}. # SUPFAM SSF52540 SSF52540 # TCDB 3.A.1.7 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR00972 3a0107s01c2 # eggNOG COG1117 LUCA # eggNOG ENOG4105BZY Bacteria BLAST swissprot:PSTB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PSTB_ECOLI BioCyc ECOL316407:JW3703-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3703-MONOMER BioCyc EcoCyc:PSTB-MONOMER http://biocyc.org/getid?id=EcoCyc:PSTB-MONOMER BioCyc MetaCyc:PSTB-MONOMER http://biocyc.org/getid?id=MetaCyc:PSTB-MONOMER COG COG1117 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1117 DIP DIP-47851N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47851N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1016/0022-2836(85)90377-8 http://dx.doi.org/10.1016/0022-2836(85)90377-8 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.3.27 {ECO:0000255|HAMAP-Rule:MF_01702} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.27 {ECO:0000255|HAMAP-Rule:MF_01702} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K01992 http://www.ebi.ac.uk/ena/data/view/K01992 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X02723 http://www.ebi.ac.uk/ena/data/view/X02723 ENZYME 3.6.3.27 {ECO:0000255|HAMAP-Rule:MF_01702} http://enzyme.expasy.org/EC/3.6.3.27 {ECO:0000255|HAMAP-Rule:MF_01702} EchoBASE EB0776 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0776 EcoGene EG10783 http://www.ecogene.org/geneInfo.php?eg_id=EG10783 EnsemblBacteria AAC76748 http://www.ensemblgenomes.org/id/AAC76748 EnsemblBacteria AAC76748 http://www.ensemblgenomes.org/id/AAC76748 EnsemblBacteria BAE77563 http://www.ensemblgenomes.org/id/BAE77563 EnsemblBacteria BAE77563 http://www.ensemblgenomes.org/id/BAE77563 EnsemblBacteria BAE77563 http://www.ensemblgenomes.org/id/BAE77563 EnsemblBacteria b3725 http://www.ensemblgenomes.org/id/b3725 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0005315 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005315 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0015415 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015415 GO_process GO:0006817 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006817 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948240 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948240 InParanoid P0AAH0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAH0 IntAct P0AAH0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAH0* IntEnz 3.6.3.27 {ECO:0000255|HAMAP-Rule:MF_01702} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.27 {ECO:0000255|HAMAP-Rule:MF_01702} InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR005670 http://www.ebi.ac.uk/interpro/entry/IPR005670 InterPro IPR015850 http://www.ebi.ac.uk/interpro/entry/IPR015850 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3703 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3703 KEGG_Gene eco:b3725 http://www.genome.jp/dbget-bin/www_bget?eco:b3725 KEGG_Orthology KO:K02036 http://www.genome.jp/dbget-bin/www_bget?KO:K02036 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 MINT MINT-1233567 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1233567 OMA MTVEPRS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MTVEPRS PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PROSITE PS51238 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51238 PSORT swissprot:PSTB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PSTB_ECOLI PSORT-B swissprot:PSTB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PSTB_ECOLI PSORT2 swissprot:PSTB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PSTB_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Phobius swissprot:PSTB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PSTB_ECOLI PhylomeDB P0AAH0 http://phylomedb.org/?seqid=P0AAH0 ProteinModelPortal P0AAH0 http://www.proteinmodelportal.org/query/uniprot/P0AAH0 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2993631 http://www.ncbi.nlm.nih.gov/pubmed/2993631 PubMed 3881386 http://www.ncbi.nlm.nih.gov/pubmed/3881386 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 8682808 http://www.ncbi.nlm.nih.gov/pubmed/8682808 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418181 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418181 RefSeq WP_000063125 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000063125 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P0AAH0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAH0 STRING 511145.b3725 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3725&targetmode=cogs STRING COG1117 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1117&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.7 http://www.tcdb.org/search/result.php?tc=3.A.1.7 TIGRFAMs TIGR00972 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00972 UniProtKB PSTB_ECOLI http://www.uniprot.org/uniprot/PSTB_ECOLI UniProtKB-AC P0AAH0 http://www.uniprot.org/uniprot/P0AAH0 charge swissprot:PSTB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PSTB_ECOLI eggNOG COG1117 http://eggnogapi.embl.de/nog_data/html/tree/COG1117 eggNOG ENOG4105BZY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZY epestfind swissprot:PSTB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PSTB_ECOLI garnier swissprot:PSTB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PSTB_ECOLI helixturnhelix swissprot:PSTB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PSTB_ECOLI hmoment swissprot:PSTB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PSTB_ECOLI iep swissprot:PSTB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PSTB_ECOLI inforesidue swissprot:PSTB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PSTB_ECOLI octanol swissprot:PSTB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PSTB_ECOLI pepcoil swissprot:PSTB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PSTB_ECOLI pepdigest swissprot:PSTB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PSTB_ECOLI pepinfo swissprot:PSTB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PSTB_ECOLI pepnet swissprot:PSTB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PSTB_ECOLI pepstats swissprot:PSTB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PSTB_ECOLI pepwheel swissprot:PSTB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PSTB_ECOLI pepwindow swissprot:PSTB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PSTB_ECOLI sigcleave swissprot:PSTB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PSTB_ECOLI ## Database ID URL or Descriptions # AltName ISPE_ECOLI 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase # BRENDA 2.7.1.148 2026 # BioGrid 4260815 276 # CATALYTIC ACTIVITY ISPE_ECOLI ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D- erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl- D-erythritol. # CAUTION Was originally thought to be an isopentenyl monophosphate kinase. {ECO:0000305|PubMed 1427085}. # EcoGene EG11294 ispE # FUNCTION ISPE_ECOLI Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. Phosphorylates isopentenyl phosphate at low rates. Also acts on isopentenol, and, much less efficiently, dimethylallyl alcohol. Dimethylallyl monophosphate does not serve as a substrate. # GO_function GO:0005524 ATP binding; IDA:EcoCyc. # GO_function GO:0050515 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity; IDA:EcoCyc. # GO_process GO:0016114 terpenoid biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0019288 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway; IEA:UniProtKB-UniPathway. # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.30.230.10 -; 1. # Gene3D 3.30.70.890 -; 1. # HAMAP MF_00061 IspE # InterPro IPR004424 IspE # InterPro IPR006204 GHMP_kinase_N_dom # InterPro IPR013750 GHMP_kinase_C_dom # InterPro IPR014721 Ribosomal_S5_D2-typ_fold_subgr # InterPro IPR020568 Ribosomal_S5_D2-typ_fold # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00900 Terpenoid backbone biosynthesis # Organism ISPE_ECOLI Escherichia coli (strain K12) # PANTHER PTHR20861:SF2 PTHR20861:SF2 # PATHWAY Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1- deoxy-D-xylulose 5-phosphate step 3/6. # PATRIC 32117668 VBIEscCol129921_1256 # PDB 2WW4 X-ray; 2.00 A; A/B=1-283 # PIR B47706 B47706 # PIRSF PIRSF010376 IspE # Pfam PF00288 GHMP_kinases_N # Pfam PF08544 GHMP_kinases_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ISPE_ECOLI 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase # RefSeq NP_415726 NC_000913.3 # RefSeq WP_001260332 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA01106.1; Type=Frameshift; Positions=50; Evidence={ECO 0000305}; # SIMILARITY Belongs to the GHMP kinase family. IspE subfamily. {ECO 0000305}. # SUBUNIT Homodimer. {ECO 0000250}. # SUPFAM SSF54211 SSF54211 # SUPFAM SSF55060 SSF55060 # TIGRFAMs TIGR00154 ispE # UniPathway UPA00056 UER00094 # eggNOG COG1947 LUCA # eggNOG ENOG4105CTR Bacteria BLAST swissprot:ISPE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ISPE_ECOLI BioCyc ECOL316407:JW1199-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1199-MONOMER BioCyc EcoCyc:EG11294-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11294-MONOMER BioCyc MetaCyc:EG11294-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11294-MONOMER COG COG1947 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1947 DIP DIP-48028N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48028N DOI 10.1016/0378-1119(92)90170-T http://dx.doi.org/10.1016/0378-1119(92)90170-T DOI 10.1016/S0006-291X(03)01211-7 http://dx.doi.org/10.1016/S0006-291X(03)01211-7 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.96.24.13714 http://dx.doi.org/10.1073/pnas.96.24.13714 DOI 10.1073/pnas.97.3.1062 http://dx.doi.org/10.1073/pnas.97.3.1062 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1099/00221287-139-2-259 http://dx.doi.org/10.1099/00221287-139-2-259 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.148 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.148 EMBL AB037116 http://www.ebi.ac.uk/ena/data/view/AB037116 EMBL AF179284 http://www.ebi.ac.uk/ena/data/view/AF179284 EMBL AF216300 http://www.ebi.ac.uk/ena/data/view/AF216300 EMBL AJ249325 http://www.ebi.ac.uk/ena/data/view/AJ249325 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D10264 http://www.ebi.ac.uk/ena/data/view/D10264 EMBL M77237 http://www.ebi.ac.uk/ena/data/view/M77237 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18555 http://www.ebi.ac.uk/ena/data/view/U18555 ENZYME 2.7.1.148 http://enzyme.expasy.org/EC/2.7.1.148 EchoBASE EB1271 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1271 EcoGene EG11294 http://www.ecogene.org/geneInfo.php?eg_id=EG11294 EnsemblBacteria AAC74292 http://www.ensemblgenomes.org/id/AAC74292 EnsemblBacteria AAC74292 http://www.ensemblgenomes.org/id/AAC74292 EnsemblBacteria BAA36066 http://www.ensemblgenomes.org/id/BAA36066 EnsemblBacteria BAA36066 http://www.ensemblgenomes.org/id/BAA36066 EnsemblBacteria BAA36066 http://www.ensemblgenomes.org/id/BAA36066 EnsemblBacteria b1208 http://www.ensemblgenomes.org/id/b1208 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0050515 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050515 GO_process GO:0016114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016114 GO_process GO:0019288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019288 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.30.230.10 http://www.cathdb.info/version/latest/superfamily/3.30.230.10 Gene3D 3.30.70.890 http://www.cathdb.info/version/latest/superfamily/3.30.70.890 GeneID 945774 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945774 HAMAP MF_00061 http://hamap.expasy.org/unirule/MF_00061 HOGENOM HOG000019601 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000019601&db=HOGENOM6 InParanoid P62615 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P62615 IntAct P62615 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P62615* IntEnz 2.7.1.148 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.148 InterPro IPR004424 http://www.ebi.ac.uk/interpro/entry/IPR004424 InterPro IPR006204 http://www.ebi.ac.uk/interpro/entry/IPR006204 InterPro IPR013750 http://www.ebi.ac.uk/interpro/entry/IPR013750 InterPro IPR014721 http://www.ebi.ac.uk/interpro/entry/IPR014721 InterPro IPR020568 http://www.ebi.ac.uk/interpro/entry/IPR020568 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1199 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1199 KEGG_Gene eco:b1208 http://www.genome.jp/dbget-bin/www_bget?eco:b1208 KEGG_Orthology KO:K00919 http://www.genome.jp/dbget-bin/www_bget?KO:K00919 KEGG_Pathway ko00900 http://www.genome.jp/kegg-bin/show_pathway?ko00900 KEGG_Reaction rn:R05634 http://www.genome.jp/dbget-bin/www_bget?rn:R05634 OMA RWPSPAK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RWPSPAK PANTHER PTHR20861:SF2 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20861:SF2 PDB 2WW4 http://www.ebi.ac.uk/pdbe-srv/view/entry/2WW4 PDBsum 2WW4 http://www.ebi.ac.uk/pdbsum/2WW4 PSORT swissprot:ISPE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ISPE_ECOLI PSORT-B swissprot:ISPE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ISPE_ECOLI PSORT2 swissprot:ISPE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ISPE_ECOLI Pfam PF00288 http://pfam.xfam.org/family/PF00288 Pfam PF08544 http://pfam.xfam.org/family/PF08544 Phobius swissprot:ISPE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ISPE_ECOLI PhylomeDB P62615 http://phylomedb.org/?seqid=P62615 ProteinModelPortal P62615 http://www.proteinmodelportal.org/query/uniprot/P62615 PubMed 10570138 http://www.ncbi.nlm.nih.gov/pubmed/10570138 PubMed 10655484 http://www.ncbi.nlm.nih.gov/pubmed/10655484 PubMed 12859972 http://www.ncbi.nlm.nih.gov/pubmed/12859972 PubMed 1427085 http://www.ncbi.nlm.nih.gov/pubmed/1427085 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7543480 http://www.ncbi.nlm.nih.gov/pubmed/7543480 PubMed 7679718 http://www.ncbi.nlm.nih.gov/pubmed/7679718 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415726 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415726 RefSeq WP_001260332 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001260332 SMR P62615 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P62615 STRING 511145.b1208 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1208&targetmode=cogs STRING COG1947 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1947&targetmode=cogs SUPFAM SSF54211 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54211 SUPFAM SSF55060 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55060 TIGRFAMs TIGR00154 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00154 UniProtKB ISPE_ECOLI http://www.uniprot.org/uniprot/ISPE_ECOLI UniProtKB-AC P62615 http://www.uniprot.org/uniprot/P62615 charge swissprot:ISPE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ISPE_ECOLI eggNOG COG1947 http://eggnogapi.embl.de/nog_data/html/tree/COG1947 eggNOG ENOG4105CTR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CTR epestfind swissprot:ISPE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ISPE_ECOLI garnier swissprot:ISPE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ISPE_ECOLI helixturnhelix swissprot:ISPE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ISPE_ECOLI hmoment swissprot:ISPE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ISPE_ECOLI iep swissprot:ISPE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ISPE_ECOLI inforesidue swissprot:ISPE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ISPE_ECOLI octanol swissprot:ISPE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ISPE_ECOLI pepcoil swissprot:ISPE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ISPE_ECOLI pepdigest swissprot:ISPE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ISPE_ECOLI pepinfo swissprot:ISPE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ISPE_ECOLI pepnet swissprot:ISPE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ISPE_ECOLI pepstats swissprot:ISPE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ISPE_ECOLI pepwheel swissprot:ISPE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ISPE_ECOLI pepwindow swissprot:ISPE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ISPE_ECOLI sigcleave swissprot:ISPE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ISPE_ECOLI ## Database ID URL or Descriptions # AltName DCP_ECOLI Dipeptidyl carboxypeptidase # BRENDA 3.4.15 2026 # BioGrid 4261739 15 # CATALYTIC ACTIVITY DCP_ECOLI Hydrolysis of unblocked, C-terminal dipeptides from oligopeptides, with broad specificity. Does not hydrolyze bonds in which P1' is Pro, or both P1 and P1' are Gly. # COFACTOR DCP_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000250}; Note=Binds 1 zinc ion. {ECO 0000250}; # ENZYME REGULATION DCP_ECOLI It is stimulated by manganese, magnesium, cobalt and calcium ions and is inhibited by zinc, copper and nickel. # EcoGene EG10212 dcp # FUNCTION DCP_ECOLI Removes dipeptides from the C-termini of N-blocked tripeptides, tetrapeptides and larger peptides. # GO_component GO:0005737 cytoplasm; IDA:EcoCyc. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0004180 carboxypeptidase activity; IDA:EcoCyc. # GO_function GO:0004222 metalloendopeptidase activity; IBA:GO_Central. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006508 proteolysis; IMP:EcoCyc. # GO_process GO:0006518 peptide metabolic process; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.1370.10 -; 2. # Gene3D 1.20.1050.40 -; 1. # Gene3D 3.40.390.10 -; 1. # IntAct P24171 4 # InterPro IPR001567 Pept_M3A_M3B # InterPro IPR024077 Neurolysin/TOP_dom2 # InterPro IPR024079 MetalloPept_cat_dom # InterPro IPR024080 Neurolysin/TOP_N # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # Organism DCP_ECOLI Escherichia coli (strain K12) # PATRIC 32118376 VBIEscCol129921_1608 # PDB 1Y79 X-ray; 2.00 A; 1=2-681 # PIR E64908 E64908 # PROSITE PS00142 ZINC_PROTEASE # Pfam PF01432 Peptidase_M3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DCP_ECOLI Peptidyl-dipeptidase dcp # RefSeq NP_416056 NC_000913.3 # RefSeq WP_000210373 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase M3 family. {ECO 0000305}. # SUBCELLULAR LOCATION DCP_ECOLI Cytoplasm. # eggNOG COG0339 LUCA # eggNOG ENOG4105DGW Bacteria BLAST swissprot:DCP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DCP_ECOLI BioCyc ECOL316407:JW1531-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1531-MONOMER BioCyc EcoCyc:EG10212-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10212-MONOMER BioCyc MetaCyc:EG10212-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10212-MONOMER COG COG0339 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0339 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.15.5 http://www.genome.jp/dbget-bin/www_bget?EC:3.4.15.5 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X57947 http://www.ebi.ac.uk/ena/data/view/X57947 ENZYME 3.4.15.5 http://enzyme.expasy.org/EC/3.4.15.5 EchoBASE EB0208 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0208 EcoGene EG10212 http://www.ecogene.org/geneInfo.php?eg_id=EG10212 EnsemblBacteria AAC74611 http://www.ensemblgenomes.org/id/AAC74611 EnsemblBacteria AAC74611 http://www.ensemblgenomes.org/id/AAC74611 EnsemblBacteria BAA15228 http://www.ensemblgenomes.org/id/BAA15228 EnsemblBacteria BAA15228 http://www.ensemblgenomes.org/id/BAA15228 EnsemblBacteria BAA15228 http://www.ensemblgenomes.org/id/BAA15228 EnsemblBacteria b1538 http://www.ensemblgenomes.org/id/b1538 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0004180 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004180 GO_function GO:0004222 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004222 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006508 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006508 GO_process GO:0006518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006518 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.1370.10 http://www.cathdb.info/version/latest/superfamily/1.10.1370.10 Gene3D 1.20.1050.40 http://www.cathdb.info/version/latest/superfamily/1.20.1050.40 Gene3D 3.40.390.10 http://www.cathdb.info/version/latest/superfamily/3.40.390.10 GeneID 946084 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946084 HOGENOM HOG000245984 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000245984&db=HOGENOM6 InParanoid P24171 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P24171 IntAct P24171 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P24171* IntEnz 3.4.15.5 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.15.5 InterPro IPR001567 http://www.ebi.ac.uk/interpro/entry/IPR001567 InterPro IPR024077 http://www.ebi.ac.uk/interpro/entry/IPR024077 InterPro IPR024079 http://www.ebi.ac.uk/interpro/entry/IPR024079 InterPro IPR024080 http://www.ebi.ac.uk/interpro/entry/IPR024080 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW1531 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1531 KEGG_Gene eco:b1538 http://www.genome.jp/dbget-bin/www_bget?eco:b1538 KEGG_Orthology KO:K01284 http://www.genome.jp/dbget-bin/www_bget?KO:K01284 OMA GTSFSHH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GTSFSHH PDB 1Y79 http://www.ebi.ac.uk/pdbe-srv/view/entry/1Y79 PDBsum 1Y79 http://www.ebi.ac.uk/pdbsum/1Y79 PROSITE PS00142 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00142 PSORT swissprot:DCP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DCP_ECOLI PSORT-B swissprot:DCP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DCP_ECOLI PSORT2 swissprot:DCP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DCP_ECOLI Pfam PF01432 http://pfam.xfam.org/family/PF01432 Phobius swissprot:DCP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DCP_ECOLI PhylomeDB P24171 http://phylomedb.org/?seqid=P24171 ProteinModelPortal P24171 http://www.proteinmodelportal.org/query/uniprot/P24171 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8226676 http://www.ncbi.nlm.nih.gov/pubmed/8226676 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416056 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416056 RefSeq WP_000210373 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000210373 SMR P24171 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P24171 STRING 511145.b1538 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1538&targetmode=cogs STRING COG0339 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0339&targetmode=cogs UniProtKB DCP_ECOLI http://www.uniprot.org/uniprot/DCP_ECOLI UniProtKB-AC P24171 http://www.uniprot.org/uniprot/P24171 charge swissprot:DCP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DCP_ECOLI eggNOG COG0339 http://eggnogapi.embl.de/nog_data/html/tree/COG0339 eggNOG ENOG4105DGW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DGW epestfind swissprot:DCP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DCP_ECOLI garnier swissprot:DCP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DCP_ECOLI helixturnhelix swissprot:DCP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DCP_ECOLI hmoment swissprot:DCP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DCP_ECOLI iep swissprot:DCP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DCP_ECOLI inforesidue swissprot:DCP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DCP_ECOLI octanol swissprot:DCP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DCP_ECOLI pepcoil swissprot:DCP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DCP_ECOLI pepdigest swissprot:DCP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DCP_ECOLI pepinfo swissprot:DCP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DCP_ECOLI pepnet swissprot:DCP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DCP_ECOLI pepstats swissprot:DCP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DCP_ECOLI pepwheel swissprot:DCP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DCP_ECOLI pepwindow swissprot:DCP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DCP_ECOLI sigcleave swissprot:DCP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DCP_ECOLI ## Database ID URL or Descriptions # BioGrid 4259252 7 # EcoGene EG14232 yqiK # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005886 plasma membrane # IntAct P77306 4 # InterPro IPR001107 Band_7 # InterPro IPR027705 Flotillin_fam # InterPro IPR031905 Flotillin_C # Organism YQIK_ECOLI Escherichia coli (strain K12) # PANTHER PTHR13806 PTHR13806 # PATRIC 32121514 VBIEscCol129921_3144 # PIR A65093 A65093 # Pfam PF01145 Band_7 # Pfam PF15975 Flot # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQIK_ECOLI Inner membrane protein YqiK # RefSeq NP_417523 NC_000913.3 # RefSeq WP_001311137 NZ_LN832404.1 # SIMILARITY To B.subtilis YuaG and Synechocystis PCC 6803 sll1021. {ECO 0000305}. # SMART SM00244 PHB # SUBCELLULAR LOCATION YQIK_ECOLI Cell inner membrane; Single-pass membrane protein. # SUPFAM SSF117892 SSF117892 # eggNOG COG2268 LUCA # eggNOG ENOG4107S78 Bacteria BLAST swissprot:YQIK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQIK_ECOLI BioCyc ECOL316407:JW3023-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3023-MONOMER BioCyc EcoCyc:G7589-MONOMER http://biocyc.org/getid?id=EcoCyc:G7589-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL AY605712 http://www.ebi.ac.uk/ena/data/view/AY605712 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3983 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3983 EcoGene EG14232 http://www.ecogene.org/geneInfo.php?eg_id=EG14232 EnsemblBacteria AAC76087 http://www.ensemblgenomes.org/id/AAC76087 EnsemblBacteria AAC76087 http://www.ensemblgenomes.org/id/AAC76087 EnsemblBacteria BAA16578 http://www.ensemblgenomes.org/id/BAA16578 EnsemblBacteria BAA16578 http://www.ensemblgenomes.org/id/BAA16578 EnsemblBacteria BAA16578 http://www.ensemblgenomes.org/id/BAA16578 EnsemblBacteria b3051 http://www.ensemblgenomes.org/id/b3051 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 947537 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947537 HOGENOM HOG000295218 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000295218&db=HOGENOM6 InParanoid P77306 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77306 IntAct P77306 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77306* InterPro IPR001107 http://www.ebi.ac.uk/interpro/entry/IPR001107 InterPro IPR027705 http://www.ebi.ac.uk/interpro/entry/IPR027705 InterPro IPR031905 http://www.ebi.ac.uk/interpro/entry/IPR031905 KEGG_Gene ecj:JW3023 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3023 KEGG_Gene eco:b3051 http://www.genome.jp/dbget-bin/www_bget?eco:b3051 OMA SMTEMHE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SMTEMHE PANTHER PTHR13806 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13806 PSORT swissprot:YQIK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQIK_ECOLI PSORT-B swissprot:YQIK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQIK_ECOLI PSORT2 swissprot:YQIK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQIK_ECOLI Pfam PF01145 http://pfam.xfam.org/family/PF01145 Pfam PF15975 http://pfam.xfam.org/family/PF15975 Phobius swissprot:YQIK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQIK_ECOLI PhylomeDB P77306 http://phylomedb.org/?seqid=P77306 ProteinModelPortal P77306 http://www.proteinmodelportal.org/query/uniprot/P77306 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417523 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417523 RefSeq WP_001311137 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001311137 SMART SM00244 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00244 SMR P77306 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77306 STRING 511145.b3051 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3051&targetmode=cogs SUPFAM SSF117892 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF117892 UniProtKB YQIK_ECOLI http://www.uniprot.org/uniprot/YQIK_ECOLI UniProtKB-AC P77306 http://www.uniprot.org/uniprot/P77306 charge swissprot:YQIK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQIK_ECOLI eggNOG COG2268 http://eggnogapi.embl.de/nog_data/html/tree/COG2268 eggNOG ENOG4107S78 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107S78 epestfind swissprot:YQIK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQIK_ECOLI garnier swissprot:YQIK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQIK_ECOLI helixturnhelix swissprot:YQIK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQIK_ECOLI hmoment swissprot:YQIK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQIK_ECOLI iep swissprot:YQIK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQIK_ECOLI inforesidue swissprot:YQIK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQIK_ECOLI octanol swissprot:YQIK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQIK_ECOLI pepcoil swissprot:YQIK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQIK_ECOLI pepdigest swissprot:YQIK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQIK_ECOLI pepinfo swissprot:YQIK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQIK_ECOLI pepnet swissprot:YQIK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQIK_ECOLI pepstats swissprot:YQIK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQIK_ECOLI pepwheel swissprot:YQIK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQIK_ECOLI pepwindow swissprot:YQIK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQIK_ECOLI sigcleave swissprot:YQIK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQIK_ECOLI ## Database ID URL or Descriptions # BioGrid 4260359 8 # EcoGene EG14028 yebZ # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR008457 Cu-R_CopD # KEGG_Brite ko02000 Transporters # Organism YEBZ_ECOLI Escherichia coli (strain K12) # PATRIC 32119001 VBIEscCol129921_1918 # PIR H64945 H64945 # Pfam PF05425 CopD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEBZ_ECOLI Inner membrane protein YebZ # RefSeq NP_416354 NC_000913.3 # RefSeq WP_000879289 NZ_LN832404.1 # SIMILARITY Belongs to the CopD family. {ECO 0000305}. # SUBCELLULAR LOCATION YEBZ_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 9.B.62.1 the copper resistance (copd) family # eggNOG COG1276 LUCA # eggNOG ENOG4108PNC Bacteria BLAST swissprot:YEBZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEBZ_ECOLI BioCyc ECOL316407:JW1829-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1829-MONOMER BioCyc EcoCyc:G7013-MONOMER http://biocyc.org/getid?id=EcoCyc:G7013-MONOMER COG COG1276 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1276 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3782 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3782 EcoGene EG14028 http://www.ecogene.org/geneInfo.php?eg_id=EG14028 EnsemblBacteria AAC74910 http://www.ensemblgenomes.org/id/AAC74910 EnsemblBacteria AAC74910 http://www.ensemblgenomes.org/id/AAC74910 EnsemblBacteria BAE76544 http://www.ensemblgenomes.org/id/BAE76544 EnsemblBacteria BAE76544 http://www.ensemblgenomes.org/id/BAE76544 EnsemblBacteria BAE76544 http://www.ensemblgenomes.org/id/BAE76544 EnsemblBacteria b1840 http://www.ensemblgenomes.org/id/b1840 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 947078 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947078 HOGENOM HOG000121218 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000121218&db=HOGENOM6 InterPro IPR008457 http://www.ebi.ac.uk/interpro/entry/IPR008457 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1829 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1829 KEGG_Gene eco:b1840 http://www.genome.jp/dbget-bin/www_bget?eco:b1840 KEGG_Orthology KO:K07245 http://www.genome.jp/dbget-bin/www_bget?KO:K07245 OMA MLWLKIA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MLWLKIA PSORT swissprot:YEBZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEBZ_ECOLI PSORT-B swissprot:YEBZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEBZ_ECOLI PSORT2 swissprot:YEBZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEBZ_ECOLI Pfam PF05425 http://pfam.xfam.org/family/PF05425 Phobius swissprot:YEBZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEBZ_ECOLI ProteinModelPortal P76278 http://www.proteinmodelportal.org/query/uniprot/P76278 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416354 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416354 RefSeq WP_000879289 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000879289 SMR P76278 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76278 STRING 511145.b1840 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1840&targetmode=cogs STRING COG1276 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1276&targetmode=cogs TCDB 9.B.62.1 http://www.tcdb.org/search/result.php?tc=9.B.62.1 UniProtKB YEBZ_ECOLI http://www.uniprot.org/uniprot/YEBZ_ECOLI UniProtKB-AC P76278 http://www.uniprot.org/uniprot/P76278 charge swissprot:YEBZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEBZ_ECOLI eggNOG COG1276 http://eggnogapi.embl.de/nog_data/html/tree/COG1276 eggNOG ENOG4108PNC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108PNC epestfind swissprot:YEBZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEBZ_ECOLI garnier swissprot:YEBZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEBZ_ECOLI helixturnhelix swissprot:YEBZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEBZ_ECOLI hmoment swissprot:YEBZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEBZ_ECOLI iep swissprot:YEBZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEBZ_ECOLI inforesidue swissprot:YEBZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEBZ_ECOLI octanol swissprot:YEBZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEBZ_ECOLI pepcoil swissprot:YEBZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEBZ_ECOLI pepdigest swissprot:YEBZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEBZ_ECOLI pepinfo swissprot:YEBZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEBZ_ECOLI pepnet swissprot:YEBZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEBZ_ECOLI pepstats swissprot:YEBZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEBZ_ECOLI pepwheel swissprot:YEBZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEBZ_ECOLI pepwindow swissprot:YEBZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEBZ_ECOLI sigcleave swissprot:YEBZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEBZ_ECOLI ## Database ID URL or Descriptions # AltName LIVM_ECOLI LIV-I protein M # BioGrid 4262489 17 # EcoGene EG10541 livM # FUNCTION LIVM_ECOLI Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015658 branched-chain amino acid transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0015803 branched-chain amino acid transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR001851 ABC_transp_permease # InterPro IPR021807 LivHM_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00237 Branched-chain amino acid transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism LIVM_ECOLI Escherichia coli (strain K12) # PATRIC 32122354 VBIEscCol129921_3554 # PIR S47675 S47675 # Pfam PF02653 BPD_transp_2 # Pfam PF11862 DUF3382 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LIVM_ECOLI High-affinity branched-chain amino acid transport system permease protein LivM # RefSeq NP_417913 NC_000913.3 # RefSeq WP_000803813 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION LIVM_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # TCDB 3.A.1.4 the atp-binding cassette (abc) superfamily # eggNOG COG4177 LUCA # eggNOG ENOG4105CF8 Bacteria BLAST swissprot:LIVM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LIVM_ECOLI BioCyc ECOL316407:JW3421-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3421-MONOMER BioCyc EcoCyc:LIVM-MONOMER http://biocyc.org/getid?id=EcoCyc:LIVM-MONOMER BioCyc MetaCyc:LIVM-MONOMER http://biocyc.org/getid?id=MetaCyc:LIVM-MONOMER COG COG0559 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0559 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J05516 http://www.ebi.ac.uk/ena/data/view/J05516 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0536 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0536 EcoGene EG10541 http://www.ecogene.org/geneInfo.php?eg_id=EG10541 EnsemblBacteria AAC76481 http://www.ensemblgenomes.org/id/AAC76481 EnsemblBacteria AAC76481 http://www.ensemblgenomes.org/id/AAC76481 EnsemblBacteria BAE77837 http://www.ensemblgenomes.org/id/BAE77837 EnsemblBacteria BAE77837 http://www.ensemblgenomes.org/id/BAE77837 EnsemblBacteria BAE77837 http://www.ensemblgenomes.org/id/BAE77837 EnsemblBacteria b3456 http://www.ensemblgenomes.org/id/b3456 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015658 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015658 GO_process GO:0015803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015803 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 947966 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947966 HOGENOM HOG000202415 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000202415&db=HOGENOM6 InParanoid P22729 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P22729 InterPro IPR001851 http://www.ebi.ac.uk/interpro/entry/IPR001851 InterPro IPR021807 http://www.ebi.ac.uk/interpro/entry/IPR021807 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3421 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3421 KEGG_Gene eco:b3456 http://www.genome.jp/dbget-bin/www_bget?eco:b3456 KEGG_Orthology KO:K01998 http://www.genome.jp/dbget-bin/www_bget?KO:K01998 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA SINKVIF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SINKVIF PSORT swissprot:LIVM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LIVM_ECOLI PSORT-B swissprot:LIVM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LIVM_ECOLI PSORT2 swissprot:LIVM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LIVM_ECOLI Pfam PF02653 http://pfam.xfam.org/family/PF02653 Pfam PF11862 http://pfam.xfam.org/family/PF11862 Phobius swissprot:LIVM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LIVM_ECOLI PhylomeDB P22729 http://phylomedb.org/?seqid=P22729 ProteinModelPortal P22729 http://www.proteinmodelportal.org/query/uniprot/P22729 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2195019 http://www.ncbi.nlm.nih.gov/pubmed/2195019 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417913 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417913 RefSeq WP_000803813 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000803813 STRING 511145.b3456 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3456&targetmode=cogs STRING COG0559 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0559&targetmode=cogs TCDB 3.A.1.4 http://www.tcdb.org/search/result.php?tc=3.A.1.4 UniProtKB LIVM_ECOLI http://www.uniprot.org/uniprot/LIVM_ECOLI UniProtKB-AC P22729 http://www.uniprot.org/uniprot/P22729 charge swissprot:LIVM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LIVM_ECOLI eggNOG COG4177 http://eggnogapi.embl.de/nog_data/html/tree/COG4177 eggNOG ENOG4105CF8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CF8 epestfind swissprot:LIVM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LIVM_ECOLI garnier swissprot:LIVM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LIVM_ECOLI helixturnhelix swissprot:LIVM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LIVM_ECOLI hmoment swissprot:LIVM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LIVM_ECOLI iep swissprot:LIVM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LIVM_ECOLI inforesidue swissprot:LIVM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LIVM_ECOLI octanol swissprot:LIVM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LIVM_ECOLI pepcoil swissprot:LIVM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LIVM_ECOLI pepdigest swissprot:LIVM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LIVM_ECOLI pepinfo swissprot:LIVM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LIVM_ECOLI pepnet swissprot:LIVM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LIVM_ECOLI pepstats swissprot:LIVM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LIVM_ECOLI pepwheel swissprot:LIVM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LIVM_ECOLI pepwindow swissprot:LIVM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LIVM_ECOLI sigcleave swissprot:LIVM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LIVM_ECOLI ## Database ID URL or Descriptions # BRENDA 3.4.23.49 2026 # FUNCTION OMPP_ECOLI Protease; also acts as a receptor for bacteriophage Ox2. # GO_component GO:0009279 cell outer membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0004190 aspartic-type endopeptidase activity; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0008233 peptidase activity # Gene3D 2.40.128.90 -; 1. # InterPro IPR000036 Peptidase_A26_omptin # InterPro IPR020079 Peptidase_A26_CS # InterPro IPR020080 OM_adhesin/peptidase_omptin # InterPro IPR023619 Peptidase_A26 # Organism OMPP_ECOLI Escherichia coli (strain K12) # PIR A36944 A36944 # PIRSF PIRSF001522 Peptidase_A26 # PRINTS PR00482 OMPTIN # PROSITE PS00834 OMPTIN_1 # PROSITE PS00835 OMPTIN_2 # Pfam PF01278 Omptin # RecName OMPP_ECOLI Outer membrane protease OmpP # RefSeq NP_061408 NC_002483.1 # RefSeq WP_001193612 NC_002483.1 # SIMILARITY Belongs to the peptidase A26 family. {ECO 0000305}. # SUBCELLULAR LOCATION OMPP_ECOLI Cell outer membrane; Multi-pass membrane protein. # SUPFAM SSF69917 SSF69917 # TCDB 9.B.50.1 the outer membrane beta-barrel endoprotease, omptin (omptin) family BLAST swissprot:OMPP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:OMPP_ECOLI DOI 10.1016/S0014-5793(99)01418-0 http://dx.doi.org/10.1016/S0014-5793(99)01418-0 EC_number EC:3.4.23.- http://www.genome.jp/dbget-bin/www_bget?EC:3.4.23.- EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL X74278 http://www.ebi.ac.uk/ena/data/view/X74278 ENZYME 3.4.23.- http://enzyme.expasy.org/EC/3.4.23.- G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0004190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004190 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 Gene3D 2.40.128.90 http://www.cathdb.info/version/latest/superfamily/2.40.128.90 GeneID 1263511 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263511 IntEnz 3.4.23 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.23 InterPro IPR000036 http://www.ebi.ac.uk/interpro/entry/IPR000036 InterPro IPR020079 http://www.ebi.ac.uk/interpro/entry/IPR020079 InterPro IPR020080 http://www.ebi.ac.uk/interpro/entry/IPR020080 InterPro IPR023619 http://www.ebi.ac.uk/interpro/entry/IPR023619 OMA KWTAYGG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KWTAYGG PRINTS PR00482 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00482 PROSITE PS00834 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00834 PROSITE PS00835 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00835 PSORT swissprot:OMPP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:OMPP_ECOLI PSORT-B swissprot:OMPP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:OMPP_ECOLI PSORT2 swissprot:OMPP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:OMPP_ECOLI Pfam PF01278 http://pfam.xfam.org/family/PF01278 Phobius swissprot:OMPP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:OMPP_ECOLI ProteinModelPortal P34210 http://www.proteinmodelportal.org/query/uniprot/P34210 PubMed 10561486 http://www.ncbi.nlm.nih.gov/pubmed/10561486 PubMed 8288530 http://www.ncbi.nlm.nih.gov/pubmed/8288530 RefSeq NP_061408 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061408 RefSeq WP_001193612 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001193612 SMR P34210 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P34210 SUPFAM SSF69917 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF69917 TCDB 9.B.50.1 http://www.tcdb.org/search/result.php?tc=9.B.50.1 UniProtKB OMPP_ECOLI http://www.uniprot.org/uniprot/OMPP_ECOLI UniProtKB-AC P34210 http://www.uniprot.org/uniprot/P34210 charge swissprot:OMPP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:OMPP_ECOLI epestfind swissprot:OMPP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:OMPP_ECOLI garnier swissprot:OMPP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:OMPP_ECOLI helixturnhelix swissprot:OMPP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:OMPP_ECOLI hmoment swissprot:OMPP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:OMPP_ECOLI iep swissprot:OMPP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:OMPP_ECOLI inforesidue swissprot:OMPP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:OMPP_ECOLI octanol swissprot:OMPP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:OMPP_ECOLI pepcoil swissprot:OMPP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:OMPP_ECOLI pepdigest swissprot:OMPP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:OMPP_ECOLI pepinfo swissprot:OMPP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:OMPP_ECOLI pepnet swissprot:OMPP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:OMPP_ECOLI pepstats swissprot:OMPP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:OMPP_ECOLI pepwheel swissprot:OMPP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:OMPP_ECOLI pepwindow swissprot:OMPP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:OMPP_ECOLI sigcleave swissprot:OMPP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:OMPP_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES LLDD_ECOLI Kinetic parameters KM=120 uM for L-lactate {ECO 0000269|PubMed 18473}; KM=770 uM for DL-alpha-hydroxybutyrate {ECO 0000269|PubMed 18473}; pH dependence Optimum pH is 8-9. {ECO 0000269|PubMed 18473}; # BioGrid 4262561 12 # CATALYTIC ACTIVITY LLDD_ECOLI (S)-lactate + an oxidized electron acceptor = pyruvate + a reduced electron acceptor. {ECO 0000255|HAMAP- Rule MF_01559, ECO 0000269|PubMed 18473}. # COFACTOR LLDD_ECOLI Name=FMN; Xref=ChEBI CHEBI 58210; Evidence={ECO 0000255|HAMAP-Rule MF_01559, ECO 0000269|PubMed 18473}; # DISRUPTION PHENOTYPE Cells lacking this gene lose the ability to grow on L-lactate as the sole source of carbon and energy, but can still utilize D-lactate. {ECO:0000269|PubMed 8407843}. # ENZYME REGULATION LLDD_ECOLI Is activated by 2-fold in the presence of high concentrations of sodium and potassium ions. Is almost completely inhibited by a high concentration of pyruvate (10 mM). # EcoGene EG11963 lldD # FUNCTION LLDD_ECOLI Catalyzes the conversion of L-lactate to pyruvate. Seems to be a primary dehydrogenase in the respiratory chain. To a lesser extent, can also oxidize DL-alpha-hydroxybutyrate, but not D-lactate. {ECO 0000269|PubMed 18473, ECO 0000269|PubMed 8407843}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_function GO:0004459 L-lactate dehydrogenase activity; IDA:EcoCyc. # GO_function GO:0010181 FMN binding; IDA:EcoCyc. # GO_process GO:0009060 aerobic respiration; IEP:EcoCyc. # GO_process GO:0019516 lactate oxidation; IMP:EcoCyc. # GO_process GO:0042355 L-fucose catabolic process; IEP:EcoCyc. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.70 -; 1. # HAMAP MF_01559 L_lact_dehydr # INDUCTION LLDD_ECOLI Is induced by aerobic growth on L-lactate, but not by aerobic growth on D-lactate or glycerol or by anaerobic growth on glucose. {ECO 0000269|PubMed 18473, ECO 0000269|PubMed 8407843}. # IntAct P33232 15 # InterPro IPR000262 FMN-dep_DH # InterPro IPR008259 FMN_hydac_DH_AS # InterPro IPR012133 Alpha-hydoxy_acid_DH_FMN # InterPro IPR013785 Aldolase_TIM # InterPro IPR020920 LldD # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00620 Pyruvate metabolism # Organism LLDD_ECOLI Escherichia coli (strain K12) # PATRIC 32122695 VBIEscCol129921_3724 # PIR C49904 C49904 # PIRSF PIRSF000138 Al-hdrx_acd_dh # PROSITE PS00557 FMN_HYDROXY_ACID_DH_1 # PROSITE PS51349 FMN_HYDROXY_ACID_DH_2 # Pfam PF01070 FMN_dh # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName L-lactate dehydrogenase {ECO:0000255|HAMAP-Rule MF_01559} # RefSeq NP_418062 NC_000913.3 # RefSeq WP_000586962 NZ_LN832404.1 # SIMILARITY Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. {ECO:0000255|HAMAP-Rule MF_01559}. # SIMILARITY Contains 1 FMN hydroxy acid dehydrogenase domain. {ECO:0000255|HAMAP-Rule MF_01559}. # SUBCELLULAR LOCATION LLDD_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01559, ECO 0000269|PubMed 18473}; Peripheral membrane protein {ECO 0000255|HAMAP-Rule MF_01559, ECO 0000269|PubMed 18473}. # SUBUNIT Forms homooligomers. {ECO:0000269|PubMed 18473}. # eggNOG COG1304 LUCA # eggNOG ENOG4105DMF Bacteria BLAST swissprot:LLDD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LLDD_ECOLI BioCyc ECOL316407:JW3580-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3580-MONOMER BioCyc EcoCyc:L-LACTDEHYDROGFMN-MONOMER http://biocyc.org/getid?id=EcoCyc:L-LACTDEHYDROGFMN-MONOMER BioCyc MetaCyc:L-LACTDEHYDROGFMN-MONOMER http://biocyc.org/getid?id=MetaCyc:L-LACTDEHYDROGFMN-MONOMER COG COG1304 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1304 DIP DIP-10108N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10108N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.-.- {ECO:0000255|HAMAP-Rule:MF_01559} http://www.genome.jp/dbget-bin/www_bget?EC:1.1.-.- {ECO:0000255|HAMAP-Rule:MF_01559} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L13970 http://www.ebi.ac.uk/ena/data/view/L13970 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.1.-.- {ECO:0000255|HAMAP-Rule:MF_01559} http://enzyme.expasy.org/EC/1.1.-.- {ECO:0000255|HAMAP-Rule:MF_01559} EchoBASE EB1906 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1906 EcoGene EG11963 http://www.ecogene.org/geneInfo.php?eg_id=EG11963 EnsemblBacteria AAC76629 http://www.ensemblgenomes.org/id/AAC76629 EnsemblBacteria AAC76629 http://www.ensemblgenomes.org/id/AAC76629 EnsemblBacteria BAE77687 http://www.ensemblgenomes.org/id/BAE77687 EnsemblBacteria BAE77687 http://www.ensemblgenomes.org/id/BAE77687 EnsemblBacteria BAE77687 http://www.ensemblgenomes.org/id/BAE77687 EnsemblBacteria b3605 http://www.ensemblgenomes.org/id/b3605 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0004459 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004459 GO_function GO:0010181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010181 GO_process GO:0009060 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009060 GO_process GO:0019516 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019516 GO_process GO:0042355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042355 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 948121 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948121 HAMAP MF_01559 http://hamap.expasy.org/unirule/MF_01559 HOGENOM HOG000217464 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000217464&db=HOGENOM6 InParanoid P33232 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33232 IntAct P33232 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33232* IntEnz 1.1.-.- {ECO:0000255|HAMAP-Rule:MF_01559} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.-.- {ECO:0000255|HAMAP-Rule:MF_01559} InterPro IPR000262 http://www.ebi.ac.uk/interpro/entry/IPR000262 InterPro IPR008259 http://www.ebi.ac.uk/interpro/entry/IPR008259 InterPro IPR012133 http://www.ebi.ac.uk/interpro/entry/IPR012133 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR020920 http://www.ebi.ac.uk/interpro/entry/IPR020920 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3580 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3580 KEGG_Gene eco:b3605 http://www.genome.jp/dbget-bin/www_bget?eco:b3605 KEGG_Orthology KO:K00101 http://www.genome.jp/dbget-bin/www_bget?KO:K00101 KEGG_Pathway ko00620 http://www.genome.jp/kegg-bin/show_pathway?ko00620 KEGG_Reaction rn:R00196 http://www.genome.jp/dbget-bin/www_bget?rn:R00196 MINT MINT-6478320 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-6478320 OMA VAWIKEQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VAWIKEQ PROSITE PS00557 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00557 PROSITE PS51349 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51349 PSORT swissprot:LLDD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LLDD_ECOLI PSORT-B swissprot:LLDD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LLDD_ECOLI PSORT2 swissprot:LLDD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LLDD_ECOLI Pfam PF01070 http://pfam.xfam.org/family/PF01070 Phobius swissprot:LLDD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LLDD_ECOLI PhylomeDB P33232 http://phylomedb.org/?seqid=P33232 ProteinModelPortal P33232 http://www.proteinmodelportal.org/query/uniprot/P33232 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18473 http://www.ncbi.nlm.nih.gov/pubmed/18473 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 8407843 http://www.ncbi.nlm.nih.gov/pubmed/8407843 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418062 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418062 RefSeq WP_000586962 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000586962 SMR P33232 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33232 STRING 511145.b3605 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3605&targetmode=cogs STRING COG1304 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1304&targetmode=cogs UniProtKB LLDD_ECOLI http://www.uniprot.org/uniprot/LLDD_ECOLI UniProtKB-AC P33232 http://www.uniprot.org/uniprot/P33232 charge swissprot:LLDD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LLDD_ECOLI eggNOG COG1304 http://eggnogapi.embl.de/nog_data/html/tree/COG1304 eggNOG ENOG4105DMF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DMF epestfind swissprot:LLDD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LLDD_ECOLI garnier swissprot:LLDD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LLDD_ECOLI helixturnhelix swissprot:LLDD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LLDD_ECOLI hmoment swissprot:LLDD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LLDD_ECOLI iep swissprot:LLDD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LLDD_ECOLI inforesidue swissprot:LLDD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LLDD_ECOLI octanol swissprot:LLDD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LLDD_ECOLI pepcoil swissprot:LLDD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LLDD_ECOLI pepdigest swissprot:LLDD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LLDD_ECOLI pepinfo swissprot:LLDD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LLDD_ECOLI pepnet swissprot:LLDD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LLDD_ECOLI pepstats swissprot:LLDD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LLDD_ECOLI pepwheel swissprot:LLDD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LLDD_ECOLI pepwindow swissprot:LLDD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LLDD_ECOLI sigcleave swissprot:LLDD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LLDD_ECOLI ## Database ID URL or Descriptions # BioGrid 4260967 10 # EcoGene EG12708 ybcI # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR007404 YdjM-like # Organism YBCI_ECOLI Escherichia coli (strain K12) # PATRIC 32116214 VBIEscCol129921_0548 # PIR F64784 F64784 # Pfam PF04307 YdjM # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBCI_ECOLI Inner membrane protein YbcI # RefSeq NP_415060 NC_000913.3 # RefSeq WP_001143542 NZ_LN832404.1 # SUBCELLULAR LOCATION YBCI_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG COG1988 LUCA # eggNOG ENOG4105S2T Bacteria BLAST swissprot:YBCI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBCI_ECOLI BioCyc ECOL316407:JW0516-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0516-MONOMER BioCyc EcoCyc:EG12708-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12708-MONOMER COG COG1988 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1988 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D10588 http://www.ebi.ac.uk/ena/data/view/D10588 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL X59293 http://www.ebi.ac.uk/ena/data/view/X59293 EchoBASE EB2570 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2570 EcoGene EG12708 http://www.ecogene.org/geneInfo.php?eg_id=EG12708 EnsemblBacteria AAC73629 http://www.ensemblgenomes.org/id/AAC73629 EnsemblBacteria AAC73629 http://www.ensemblgenomes.org/id/AAC73629 EnsemblBacteria BAE76304 http://www.ensemblgenomes.org/id/BAE76304 EnsemblBacteria BAE76304 http://www.ensemblgenomes.org/id/BAE76304 EnsemblBacteria BAE76304 http://www.ensemblgenomes.org/id/BAE76304 EnsemblBacteria b0527 http://www.ensemblgenomes.org/id/b0527 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 945155 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945155 HOGENOM HOG000280460 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000280460&db=HOGENOM6 InParanoid P45570 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45570 InterPro IPR007404 http://www.ebi.ac.uk/interpro/entry/IPR007404 KEGG_Gene ecj:JW0516 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0516 KEGG_Gene eco:b0527 http://www.genome.jp/dbget-bin/www_bget?eco:b0527 KEGG_Orthology KO:K07038 http://www.genome.jp/dbget-bin/www_bget?KO:K07038 OMA TVWIPLL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TVWIPLL PSORT swissprot:YBCI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBCI_ECOLI PSORT-B swissprot:YBCI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBCI_ECOLI PSORT2 swissprot:YBCI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBCI_ECOLI Pfam PF04307 http://pfam.xfam.org/family/PF04307 Phobius swissprot:YBCI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBCI_ECOLI PhylomeDB P45570 http://phylomedb.org/?seqid=P45570 ProteinModelPortal P45570 http://www.proteinmodelportal.org/query/uniprot/P45570 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415060 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415060 RefSeq WP_001143542 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001143542 STRING 511145.b0527 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0527&targetmode=cogs STRING COG1988 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1988&targetmode=cogs UniProtKB YBCI_ECOLI http://www.uniprot.org/uniprot/YBCI_ECOLI UniProtKB-AC P45570 http://www.uniprot.org/uniprot/P45570 charge swissprot:YBCI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBCI_ECOLI eggNOG COG1988 http://eggnogapi.embl.de/nog_data/html/tree/COG1988 eggNOG ENOG4105S2T http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105S2T epestfind swissprot:YBCI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBCI_ECOLI garnier swissprot:YBCI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBCI_ECOLI helixturnhelix swissprot:YBCI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBCI_ECOLI hmoment swissprot:YBCI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBCI_ECOLI iep swissprot:YBCI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBCI_ECOLI inforesidue swissprot:YBCI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBCI_ECOLI octanol swissprot:YBCI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBCI_ECOLI pepcoil swissprot:YBCI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBCI_ECOLI pepdigest swissprot:YBCI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBCI_ECOLI pepinfo swissprot:YBCI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBCI_ECOLI pepnet swissprot:YBCI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBCI_ECOLI pepstats swissprot:YBCI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBCI_ECOLI pepwheel swissprot:YBCI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBCI_ECOLI pepwindow swissprot:YBCI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBCI_ECOLI sigcleave swissprot:YBCI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBCI_ECOLI ## Database ID URL or Descriptions # BioGrid 4259772 55 # DISRUPTION PHENOTYPE Cells missing dinJ-yafQ have reduced biofilm formation. {ECO:0000269|PubMed 19707553}. # EcoGene EG13142 dinJ # FUNCTION DINJ_ECOLI Antitoxin component of a toxin-antitoxin (TA) module. A labile antitoxin that counteracts the effect of the YafQ toxin. YafQ and DinJ together bind their own promoter, and by analogy to other TA modules probably repress its expression. # FUNCTION DINJ_ECOLI Cell death governed by the MazE-MazF and DinJ-YafQ TA modules seems to play a role in biofilm formation. # GO_function GO:0000986 bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0015643 toxic substance binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0044010 single-species biofilm formation; IMP:EcoCyc. # GO_process GO:2000143 negative regulation of DNA-templated transcription, initiation; IDA:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # INDUCTION Not induced by the DNA damaging agent mitomycin C. {ECO:0000269|PubMed 19210620}. # IntAct Q47150 2 # InterPro IPR007337 RelB/DinJ # InterPro IPR026262 DinJ # Organism DINJ_ECOLI Escherichia coli (strain K12) # PATRIC 32115567 VBIEscCol129921_0228 # PDB 4Q2U X-ray; 1.80 A; A/C/E/G/I/K/M/O=1-86 # PIR C64747 C64747 # PIRSF PIRSF003108 DinJ # PTM DINJ_ECOLI Probably degraded by the Lon and ClpPX proteases in vivo. # Pfam PF04221 RelB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DINJ_ECOLI Antitoxin DinJ # RefSeq NP_414761 NC_000913.3 # RefSeq WP_000729703 NZ_LN832404.1 # SIMILARITY Belongs to the RelB/DinJ antitoxin family. {ECO 0000305}. # SUBUNIT DINJ_ECOLI Forms a complex with toxin YafQ, possibly a heterotetramer. In this complex the toxin activity is inhibited. {ECO 0000269|PubMed 17263853, ECO 0000269|PubMed 19210620}. # TIGRFAMs TIGR02384 RelB_DinJ # eggNOG COG3077 LUCA # eggNOG ENOG4105QHH Bacteria BLAST swissprot:DINJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DINJ_ECOLI BioCyc ECOL316407:JW0216-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0216-MONOMER BioCyc EcoCyc:G6110-MONOMER http://biocyc.org/getid?id=EcoCyc:G6110-MONOMER BioCyc MetaCyc:G6110-MONOMER http://biocyc.org/getid?id=MetaCyc:G6110-MONOMER COG COG3077 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3077 DIP DIP-9446N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9446N DOI 10.1016/0165-7992(95)90024-1 http://dx.doi.org/10.1016/0165-7992(95)90024-1 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2008.06572.x http://dx.doi.org/10.1111/j.1365-2958.2008.06572.x DOI 10.1111/j.1574-6968.2006.00563.x http://dx.doi.org/10.1111/j.1574-6968.2006.00563.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pone.0006785 http://dx.doi.org/10.1371/journal.pone.0006785 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D38582 http://www.ebi.ac.uk/ena/data/view/D38582 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2936 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2936 EcoGene EG13142 http://www.ecogene.org/geneInfo.php?eg_id=EG13142 EnsemblBacteria AAC73330 http://www.ensemblgenomes.org/id/AAC73330 EnsemblBacteria AAC73330 http://www.ensemblgenomes.org/id/AAC73330 EnsemblBacteria BAA77896 http://www.ensemblgenomes.org/id/BAA77896 EnsemblBacteria BAA77896 http://www.ensemblgenomes.org/id/BAA77896 EnsemblBacteria BAA77896 http://www.ensemblgenomes.org/id/BAA77896 EnsemblBacteria b0226 http://www.ensemblgenomes.org/id/b0226 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000986 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000986 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0015643 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015643 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0044010 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044010 GO_process GO:2000143 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000143 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 944914 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944914 HOGENOM HOG000008424 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000008424&db=HOGENOM6 IntAct Q47150 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q47150* InterPro IPR007337 http://www.ebi.ac.uk/interpro/entry/IPR007337 InterPro IPR026262 http://www.ebi.ac.uk/interpro/entry/IPR026262 KEGG_Gene ecj:JW0216 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0216 KEGG_Gene eco:b0226 http://www.genome.jp/dbget-bin/www_bget?eco:b0226 KEGG_Orthology KO:K07473 http://www.genome.jp/dbget-bin/www_bget?KO:K07473 OMA FEVRIPN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FEVRIPN PDB 4Q2U http://www.ebi.ac.uk/pdbe-srv/view/entry/4Q2U PDBsum 4Q2U http://www.ebi.ac.uk/pdbsum/4Q2U PSORT swissprot:DINJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DINJ_ECOLI PSORT-B swissprot:DINJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DINJ_ECOLI PSORT2 swissprot:DINJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DINJ_ECOLI Pfam PF04221 http://pfam.xfam.org/family/PF04221 Phobius swissprot:DINJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DINJ_ECOLI ProteinModelPortal Q47150 http://www.proteinmodelportal.org/query/uniprot/Q47150 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17263853 http://www.ncbi.nlm.nih.gov/pubmed/17263853 PubMed 19210620 http://www.ncbi.nlm.nih.gov/pubmed/19210620 PubMed 19707553 http://www.ncbi.nlm.nih.gov/pubmed/19707553 PubMed 7596361 http://www.ncbi.nlm.nih.gov/pubmed/7596361 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414761 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414761 RefSeq WP_000729703 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000729703 SMR Q47150 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q47150 STRING 511145.b0226 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0226&targetmode=cogs STRING COG3077 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3077&targetmode=cogs TIGRFAMs TIGR02384 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02384 UniProtKB DINJ_ECOLI http://www.uniprot.org/uniprot/DINJ_ECOLI UniProtKB-AC Q47150 http://www.uniprot.org/uniprot/Q47150 charge swissprot:DINJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DINJ_ECOLI eggNOG COG3077 http://eggnogapi.embl.de/nog_data/html/tree/COG3077 eggNOG ENOG4105QHH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105QHH epestfind swissprot:DINJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DINJ_ECOLI garnier swissprot:DINJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DINJ_ECOLI helixturnhelix swissprot:DINJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DINJ_ECOLI hmoment swissprot:DINJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DINJ_ECOLI iep swissprot:DINJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DINJ_ECOLI inforesidue swissprot:DINJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DINJ_ECOLI octanol swissprot:DINJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DINJ_ECOLI pepcoil swissprot:DINJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DINJ_ECOLI pepdigest swissprot:DINJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DINJ_ECOLI pepinfo swissprot:DINJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DINJ_ECOLI pepnet swissprot:DINJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DINJ_ECOLI pepstats swissprot:DINJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DINJ_ECOLI pepwheel swissprot:DINJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DINJ_ECOLI pepwindow swissprot:DINJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DINJ_ECOLI sigcleave swissprot:DINJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DINJ_ECOLI ## Database ID URL or Descriptions # AltName Succinyl-CoA synthetase subunit alpha {ECO:0000255|HAMAP-Rule MF_01988} # BIOPHYSICOCHEMICAL PROPERTIES SUCD_ECOLI Kinetic parameters KM=0.25 mM for succinate {ECO 0000269|PubMed 10353839}; KM=4 uM for CoA {ECO 0000269|PubMed 10353839}; Note=kcat is 2684 min(-1) with ATP as substrate and 1471 min(-1) with GTP as substrate. {ECO 0000269|PubMed 10353839}; # BRENDA 6.2.1 2165 # BioGrid 4259936 23 # CATALYTIC ACTIVITY SUCD_ECOLI ATP + succinate + CoA = ADP + phosphate + succinyl-CoA. {ECO 0000255|HAMAP-Rule MF_01988, ECO 0000269|PubMed 10353839}. # ENZYME REGULATION Exhibits two interesting properties "substrate synergism", in which the enzyme is most active for the catalysis of its partial reactions only when all the substrate-binding sites are occupied, and "catalytic cooperativity" between alternating active sites in the tetramer, whereby the interaction of substrates (particularly ATP) at one site is needed to promote catalysis at the other. # EcoGene EG10982 sucD # FUNCTION SUCD_ECOLI Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. Can use either ATP or GTP, but prefers ATP. It can also function in the other direction for anabolic purposes, and this may be particularly important for providing succinyl-CoA during anaerobic growth when the oxidative route from 2- oxoglutarate is severely repressed. {ECO 0000255|HAMAP- Rule MF_01988, ECO 0000269|PubMed 10353839}. # GO_component GO:0005737 cytoplasm; IDA:UniProtKB. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0009361 succinate-CoA ligase complex (ADP-forming); IDA:EcoCyc. # GO_function GO:0004775 succinate-CoA ligase (ADP-forming) activity; IBA:GO_Central. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0048037 cofactor binding; IEA:InterPro. # GO_process GO:0006099 tricarboxylic acid cycle; IBA:GO_Central. # GO_process GO:0006104 succinyl-CoA metabolic process; IBA:GO_Central. # GO_process GO:0006105 succinate metabolic process; IBA:GO_Central. # GO_process GO:0009142 nucleoside triphosphate biosynthetic process; IBA:GO_Central. # GO_process GO:0046777 protein autophosphorylation; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.261 -; 1. # Gene3D 3.40.50.720 -; 1. # HAMAP MF_01988 Succ_CoA_alpha # INTERACTION SUCD_ECOLI P0A836 sucC; NbExp=3; IntAct=EBI-369078, EBI-369117; # IntAct P0AGE9 7 # InterPro IPR003781 CoA-bd # InterPro IPR005810 CoA_lig_alpha # InterPro IPR005811 CoA_ligase # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR016102 Succinyl-CoA_synth-like # InterPro IPR017440 Cit_synth/succinyl-CoA_lig_AS # InterPro IPR033847 Citrt_syn/SCS-alpha_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00020 Citrate cycle (TCA cycle) # KEGG_Pathway ko00640 Propanoate metabolism # KEGG_Pathway ko00660 C5-Branched dibasic acid metabolism # KEGG_Pathway ko00720 Carbon fixation pathways in prokaryotes # MISCELLANEOUS SUCD_ECOLI Succinyl-CoA synthetase (SCS) of E.coli catalyzes its reaction via three steps that involve phosphoryl enzyme and enzyme-bound succinyl phosphate as intermediates. # Organism SUCD_ECOLI Escherichia coli (strain K12) # PATHWAY SUCD_ECOLI Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route) step 1/1. {ECO 0000255|HAMAP-Rule MF_01988, ECO 0000305|PubMed 10353839}. # PATRIC 32116653 VBIEscCol129921_0759 # PDB 1CQI X-ray; 3.30 A; A/D=2-287 # PDB 1CQJ X-ray; 2.90 A; A/D=2-287 # PDB 1JKJ X-ray; 2.35 A; A/D=2-289 # PDB 1JLL X-ray; 2.69 A; A/D=2-289 # PDB 1SCU X-ray; 2.50 A; A/D=2-289 # PDB 2NU6 X-ray; 2.55 A; A/D=2-289 # PDB 2NU7 X-ray; 2.20 A; A/D=2-289 # PDB 2NU8 X-ray; 2.15 A; A/D=2-289 # PDB 2NU9 X-ray; 2.90 A; A/D/F/H=2-289 # PDB 2NUA X-ray; 2.95 A; A/D=2-289 # PDB 2SCU X-ray; 2.30 A; A/D=2-289 # PIR A90499 SYECSA # PIRSF PIRSF001553 SucCS_alpha # PROSITE PS00399 SUCCINYL_COA_LIG_2 # PROSITE PS01216 SUCCINYL_COA_LIG_1 # Pfam PF00549 Ligase_CoA # Pfam PF02629 CoA_binding # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Succinate--CoA ligase [ADP-forming] subunit alpha {ECO:0000255|HAMAP-Rule MF_01988} # RefSeq NP_415257 NC_000913.3 # RefSeq WP_000025458 NZ_LN832404.1 # SIMILARITY Belongs to the succinate/malate CoA ligase alpha subunit family. {ECO:0000255|HAMAP-Rule MF_01988}. # SMART SM00881 CoA_binding # SUBUNIT SUCD_ECOLI Heterotetramer of two alpha and two beta subunits. {ECO 0000255|HAMAP-Rule MF_01988, ECO 0000269|PubMed 8144675, ECO 0000269|PubMed 9917402}. # SUPFAM SSF51735 SSF51735 # SUPFAM SSF52210 SSF52210 # TIGRFAMs TIGR01019 sucCoAalpha # UniPathway UPA00223 UER00999 # eggNOG COG0074 LUCA # eggNOG ENOG4105CH8 Bacteria BLAST swissprot:SUCD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SUCD_ECOLI BioCyc ECOL316407:JW0718-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0718-MONOMER BioCyc EcoCyc:SUCCCOASYN-ALPHA http://biocyc.org/getid?id=EcoCyc:SUCCCOASYN-ALPHA BioCyc MetaCyc:SUCCCOASYN-ALPHA http://biocyc.org/getid?id=MetaCyc:SUCCCOASYN-ALPHA COG COG0074 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0074 DIP DIP-31851N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31851N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1998.2324 http://dx.doi.org/10.1006/jmbi.1998.2324 DOI 10.1021/bi00343a031 http://dx.doi.org/10.1021/bi00343a031 DOI 10.1021/bi011518y http://dx.doi.org/10.1021/bi011518y DOI 10.1021/bi990527s http://dx.doi.org/10.1021/bi990527s DOI 10.1021/bi991696f http://dx.doi.org/10.1021/bi991696f DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2600737 http://dx.doi.org/10.1042/bj2600737 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1107/S0907444907029319 http://dx.doi.org/10.1107/S0907444907029319 DOI 10.1111/j.1365-2958.1995.tb02270.x http://dx.doi.org/10.1111/j.1365-2958.1995.tb02270.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.2.1.5 {ECO:0000255|HAMAP-Rule:MF_01988, ECO:0000269|PubMed:10353839} http://www.genome.jp/dbget-bin/www_bget?EC:6.2.1.5 {ECO:0000255|HAMAP-Rule:MF_01988, ECO:0000269|PubMed:10353839} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01619 http://www.ebi.ac.uk/ena/data/view/J01619 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X15790 http://www.ebi.ac.uk/ena/data/view/X15790 ENZYME 6.2.1.5 {ECO:0000255|HAMAP-Rule:MF_01988, ECO:0000269|PubMed:10353839} http://enzyme.expasy.org/EC/6.2.1.5 {ECO:0000255|HAMAP-Rule:MF_01988, ECO:0000269|PubMed:10353839} EchoBASE EB0975 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0975 EcoGene EG10982 http://www.ecogene.org/geneInfo.php?eg_id=EG10982 EnsemblBacteria AAC73823 http://www.ensemblgenomes.org/id/AAC73823 EnsemblBacteria AAC73823 http://www.ensemblgenomes.org/id/AAC73823 EnsemblBacteria BAA35395 http://www.ensemblgenomes.org/id/BAA35395 EnsemblBacteria BAA35395 http://www.ensemblgenomes.org/id/BAA35395 EnsemblBacteria BAA35395 http://www.ensemblgenomes.org/id/BAA35395 EnsemblBacteria b0729 http://www.ensemblgenomes.org/id/b0729 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0009361 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009361 GO_function GO:0004775 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004775 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0048037 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048037 GO_process GO:0006099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006099 GO_process GO:0006104 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006104 GO_process GO:0006105 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006105 GO_process GO:0009142 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009142 GO_process GO:0046777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046777 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.261 http://www.cathdb.info/version/latest/superfamily/3.40.50.261 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 945314 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945314 HAMAP MF_01988 http://hamap.expasy.org/unirule/MF_01988 HOGENOM HOG000239685 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000239685&db=HOGENOM6 InParanoid P0AGE9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGE9 IntAct P0AGE9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AGE9* IntEnz 6.2.1.5 {ECO:0000255|HAMAP-Rule:MF_01988, ECO:0000269|PubMed:10353839} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.2.1.5 {ECO:0000255|HAMAP-Rule:MF_01988, ECO:0000269|PubMed:10353839} InterPro IPR003781 http://www.ebi.ac.uk/interpro/entry/IPR003781 InterPro IPR005810 http://www.ebi.ac.uk/interpro/entry/IPR005810 InterPro IPR005811 http://www.ebi.ac.uk/interpro/entry/IPR005811 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR016102 http://www.ebi.ac.uk/interpro/entry/IPR016102 InterPro IPR017440 http://www.ebi.ac.uk/interpro/entry/IPR017440 InterPro IPR033847 http://www.ebi.ac.uk/interpro/entry/IPR033847 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0718 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0718 KEGG_Gene eco:b0729 http://www.genome.jp/dbget-bin/www_bget?eco:b0729 KEGG_Orthology KO:K01902 http://www.genome.jp/dbget-bin/www_bget?KO:K01902 KEGG_Pathway ko00020 http://www.genome.jp/kegg-bin/show_pathway?ko00020 KEGG_Pathway ko00640 http://www.genome.jp/kegg-bin/show_pathway?ko00640 KEGG_Pathway ko00660 http://www.genome.jp/kegg-bin/show_pathway?ko00660 KEGG_Pathway ko00720 http://www.genome.jp/kegg-bin/show_pathway?ko00720 KEGG_Reaction rn:R00405 http://www.genome.jp/dbget-bin/www_bget?rn:R00405 KEGG_Reaction rn:R02404 http://www.genome.jp/dbget-bin/www_bget?rn:R02404 MINT MINT-1219451 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1219451 OMA VIICITE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VIICITE PDB 1CQI http://www.ebi.ac.uk/pdbe-srv/view/entry/1CQI PDB 1CQJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1CQJ PDB 1JKJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1JKJ PDB 1JLL http://www.ebi.ac.uk/pdbe-srv/view/entry/1JLL PDB 1SCU http://www.ebi.ac.uk/pdbe-srv/view/entry/1SCU PDB 2NU6 http://www.ebi.ac.uk/pdbe-srv/view/entry/2NU6 PDB 2NU7 http://www.ebi.ac.uk/pdbe-srv/view/entry/2NU7 PDB 2NU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/2NU8 PDB 2NU9 http://www.ebi.ac.uk/pdbe-srv/view/entry/2NU9 PDB 2NUA http://www.ebi.ac.uk/pdbe-srv/view/entry/2NUA PDB 2SCU http://www.ebi.ac.uk/pdbe-srv/view/entry/2SCU PDBsum 1CQI http://www.ebi.ac.uk/pdbsum/1CQI PDBsum 1CQJ http://www.ebi.ac.uk/pdbsum/1CQJ PDBsum 1JKJ http://www.ebi.ac.uk/pdbsum/1JKJ PDBsum 1JLL http://www.ebi.ac.uk/pdbsum/1JLL PDBsum 1SCU http://www.ebi.ac.uk/pdbsum/1SCU PDBsum 2NU6 http://www.ebi.ac.uk/pdbsum/2NU6 PDBsum 2NU7 http://www.ebi.ac.uk/pdbsum/2NU7 PDBsum 2NU8 http://www.ebi.ac.uk/pdbsum/2NU8 PDBsum 2NU9 http://www.ebi.ac.uk/pdbsum/2NU9 PDBsum 2NUA http://www.ebi.ac.uk/pdbsum/2NUA PDBsum 2SCU http://www.ebi.ac.uk/pdbsum/2SCU PROSITE PS00399 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00399 PROSITE PS01216 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01216 PSORT swissprot:SUCD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SUCD_ECOLI PSORT-B swissprot:SUCD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SUCD_ECOLI PSORT2 swissprot:SUCD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SUCD_ECOLI Pfam PF00549 http://pfam.xfam.org/family/PF00549 Pfam PF02629 http://pfam.xfam.org/family/PF02629 Phobius swissprot:SUCD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SUCD_ECOLI PhylomeDB P0AGE9 http://phylomedb.org/?seqid=P0AGE9 ProteinModelPortal P0AGE9 http://www.proteinmodelportal.org/query/uniprot/P0AGE9 PubMed 10353839 http://www.ncbi.nlm.nih.gov/pubmed/10353839 PubMed 10625475 http://www.ncbi.nlm.nih.gov/pubmed/10625475 PubMed 11781092 http://www.ncbi.nlm.nih.gov/pubmed/11781092 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17642514 http://www.ncbi.nlm.nih.gov/pubmed/17642514 PubMed 2548486 http://www.ncbi.nlm.nih.gov/pubmed/2548486 PubMed 3002435 http://www.ncbi.nlm.nih.gov/pubmed/3002435 PubMed 7783627 http://www.ncbi.nlm.nih.gov/pubmed/7783627 PubMed 8144675 http://www.ncbi.nlm.nih.gov/pubmed/8144675 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9917402 http://www.ncbi.nlm.nih.gov/pubmed/9917402 RefSeq NP_415257 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415257 RefSeq WP_000025458 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000025458 SMART SM00881 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00881 SMR P0AGE9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AGE9 STRING 511145.b0729 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0729&targetmode=cogs STRING COG0074 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0074&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 SUPFAM SSF52210 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52210 SWISS-2DPAGE P0AGE9 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AGE9 TIGRFAMs TIGR01019 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01019 UniProtKB SUCD_ECOLI http://www.uniprot.org/uniprot/SUCD_ECOLI UniProtKB-AC P0AGE9 http://www.uniprot.org/uniprot/P0AGE9 charge swissprot:SUCD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SUCD_ECOLI eggNOG COG0074 http://eggnogapi.embl.de/nog_data/html/tree/COG0074 eggNOG ENOG4105CH8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CH8 epestfind swissprot:SUCD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SUCD_ECOLI garnier swissprot:SUCD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SUCD_ECOLI helixturnhelix swissprot:SUCD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SUCD_ECOLI hmoment swissprot:SUCD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SUCD_ECOLI iep swissprot:SUCD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SUCD_ECOLI inforesidue swissprot:SUCD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SUCD_ECOLI octanol swissprot:SUCD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SUCD_ECOLI pepcoil swissprot:SUCD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SUCD_ECOLI pepdigest swissprot:SUCD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SUCD_ECOLI pepinfo swissprot:SUCD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SUCD_ECOLI pepnet swissprot:SUCD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SUCD_ECOLI pepstats swissprot:SUCD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SUCD_ECOLI pepwheel swissprot:SUCD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SUCD_ECOLI pepwindow swissprot:SUCD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SUCD_ECOLI sigcleave swissprot:SUCD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SUCD_ECOLI ## Database ID URL or Descriptions # BRENDA 2.7.7 2026 # BioGrid 4262182 113 # CATALYTIC ACTIVITY DPO1_ECOLI Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). # DrugBank DB00548 Azelaic Acid # EcoGene EG10746 polA # FUNCTION DPO1_ECOLI In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' and 5' to 3' exonuclease activity. It is able to utilize nicked circular duplex DNA as a template and can unwind the parental DNA strand from its template. # GO_component GO:0005737 cytoplasm; IDA:EcoCyc. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0003887 DNA-directed DNA polymerase activity; IDA:EcoCyc. # GO_function GO:0008408 3'-5' exonuclease activity; IDA:EcoCyc. # GO_function GO:0008409 5'-3' exonuclease activity; IDA:EcoCyc. # GO_process GO:0006260 DNA replication; IDA:EcoCyc. # GO_process GO:0006261 DNA-dependent DNA replication; IDA:EcoCyc. # GO_process GO:0006281 DNA repair; IMP:EcoCyc. # GO_process GO:0006284 base-excision repair; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004518 nuclease activity # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.30.420.10 -; 1. # Gene3D 3.40.50.1010 -; 1. # IntAct P00582 28 # InterPro IPR001098 DNA-dir_DNA_pol_A_palm_dom # InterPro IPR002298 DNA_polymerase_A # InterPro IPR002421 5-3_exonuclease_N # InterPro IPR002562 3'-5'_exonuclease_dom # InterPro IPR008918 HhH2 # InterPro IPR012337 RNaseH-like_dom # InterPro IPR018320 DNA_polymerase_1 # InterPro IPR019760 DNA-dir_DNA_pol_A_CS # InterPro IPR020045 5-3_exonuclease_C # InterPro IPR020046 5-3_exonucl_a-hlix_arch_N # InterPro IPR029060 PIN_domain-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03032 DNA replication proteins # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00240 Pyrimidine metabolism # KEGG_Pathway ko03030 DNA replication # KEGG_Pathway ko03410 Base excision repair # KEGG_Pathway ko03420 Nucleotide excision repair # KEGG_Pathway ko03440 Homologous recombination # Organism DPO1_ECOLI Escherichia coli (strain K12) # PATRIC 32123225 VBIEscCol129921_3973 # PDB 1D8Y X-ray; 2.08 A; A=324-928 # PDB 1D9D X-ray; 2.18 A; A=324-928 # PDB 1D9F X-ray; 3.00 A; A=324-928 # PDB 1DPI X-ray; 2.80 A; A=324-928 # PDB 1KFD X-ray; 3.90 A; A=324-928 # PDB 1KFS X-ray; 2.10 A; A=324-928 # PDB 1KLN X-ray; 3.20 A; A=324-928 # PDB 1KRP X-ray; 2.20 A; A=324-928 # PDB 1KSP X-ray; 2.30 A; A=324-928 # PDB 1QSL X-ray; 2.20 A; A=324-928 # PDB 2KFN X-ray; 2.03 A; A=324-928 # PDB 2KFZ X-ray; 2.03 A; A=324-928 # PDB 2KZM X-ray; 2.60 A; A=324-928 # PDB 2KZZ X-ray; 2.25 A; A=324-928 # PIR A92360 DJECI # PRINTS PR00868 DNAPOLI # PROSITE PS00447 DNA_POLYMERASE_A # Pfam PF00476 DNA_pol_A # Pfam PF01367 5_3_exonuc # Pfam PF01612 DNA_pol_A_exo1 # Pfam PF02739 5_3_exonuc_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DPO1_ECOLI DNA polymerase I # RefSeq NP_418300 NC_000913.3 # RefSeq WP_000250006 NZ_LN832404.1 # SIMILARITY Belongs to the DNA polymerase type-A family. {ECO 0000305}. # SIMILARITY Contains 1 3'-5' exonuclease domain. {ECO 0000305}. # SIMILARITY Contains 1 5'-3' exonuclease domain. {ECO 0000305}. # SMART SM00279 HhH2 # SMART SM00474 35EXOc # SMART SM00475 53EXOc # SMART SM00482 POLAc # SUBUNIT DPO1_ECOLI Single-chain monomer with multiple functions. # SUPFAM SSF47807 SSF47807 # SUPFAM SSF53098 SSF53098 # SUPFAM SSF88723 SSF88723 # TIGRFAMs TIGR00593 pola # eggNOG COG0258 LUCA # eggNOG COG0749 LUCA # eggNOG ENOG4105C2M Bacteria BLAST swissprot:DPO1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DPO1_ECOLI BioCyc ECOL316407:JW3835-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3835-MONOMER BioCyc EcoCyc:EG10746-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10746-MONOMER BioCyc MetaCyc:EG10746-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10746-MONOMER COG COG0258 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0258 COG COG0749 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0749 DIP DIP-10524N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10524N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/abbi.1993.1130 http://dx.doi.org/10.1006/abbi.1993.1130 DOI 10.1006/jmbi.1997.1586 http://dx.doi.org/10.1006/jmbi.1997.1586 DOI 10.1016/0022-2836(83)90049-9 http://dx.doi.org/10.1016/0022-2836(83)90049-9 DOI 10.1021/bi00214a004 http://dx.doi.org/10.1021/bi00214a004 DOI 10.1021/bi981537g http://dx.doi.org/10.1021/bi981537g DOI 10.1038/313762a0 http://dx.doi.org/10.1038/313762a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.96.25.14240 http://dx.doi.org/10.1073/pnas.96.25.14240 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1126/science.8469987 http://dx.doi.org/10.1126/science.8469987 DrugBank DB00548 http://www.drugbank.ca/drugs/DB00548 EC_number EC:2.7.7.7 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.7 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01663 http://www.ebi.ac.uk/ena/data/view/J01663 EMBL J01664 http://www.ebi.ac.uk/ena/data/view/J01664 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00317 http://www.ebi.ac.uk/ena/data/view/V00317 ENZYME 2.7.7.7 http://enzyme.expasy.org/EC/2.7.7.7 EchoBASE EB0739 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0739 EcoGene EG10746 http://www.ecogene.org/geneInfo.php?eg_id=EG10746 EnsemblBacteria AAC76861 http://www.ensemblgenomes.org/id/AAC76861 EnsemblBacteria AAC76861 http://www.ensemblgenomes.org/id/AAC76861 EnsemblBacteria BAE77445 http://www.ensemblgenomes.org/id/BAE77445 EnsemblBacteria BAE77445 http://www.ensemblgenomes.org/id/BAE77445 EnsemblBacteria BAE77445 http://www.ensemblgenomes.org/id/BAE77445 EnsemblBacteria b3863 http://www.ensemblgenomes.org/id/b3863 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003887 GO_function GO:0008408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008408 GO_function GO:0008409 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008409 GO_process GO:0006260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260 GO_process GO:0006261 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006261 GO_process GO:0006281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006281 GO_process GO:0006284 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006284 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.30.420.10 http://www.cathdb.info/version/latest/superfamily/3.30.420.10 Gene3D 3.40.50.1010 http://www.cathdb.info/version/latest/superfamily/3.40.50.1010 GeneID 948356 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948356 HOGENOM HOG000020998 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000020998&db=HOGENOM6 InParanoid P00582 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00582 IntAct P00582 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00582* IntEnz 2.7.7.7 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.7 InterPro IPR001098 http://www.ebi.ac.uk/interpro/entry/IPR001098 InterPro IPR002298 http://www.ebi.ac.uk/interpro/entry/IPR002298 InterPro IPR002421 http://www.ebi.ac.uk/interpro/entry/IPR002421 InterPro IPR002562 http://www.ebi.ac.uk/interpro/entry/IPR002562 InterPro IPR008918 http://www.ebi.ac.uk/interpro/entry/IPR008918 InterPro IPR012337 http://www.ebi.ac.uk/interpro/entry/IPR012337 InterPro IPR018320 http://www.ebi.ac.uk/interpro/entry/IPR018320 InterPro IPR019760 http://www.ebi.ac.uk/interpro/entry/IPR019760 InterPro IPR020045 http://www.ebi.ac.uk/interpro/entry/IPR020045 InterPro IPR020046 http://www.ebi.ac.uk/interpro/entry/IPR020046 InterPro IPR029060 http://www.ebi.ac.uk/interpro/entry/IPR029060 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03032 http://www.genome.jp/dbget-bin/www_bget?ko03032 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW3835 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3835 KEGG_Gene eco:b3863 http://www.genome.jp/dbget-bin/www_bget?eco:b3863 KEGG_Orthology KO:K02335 http://www.genome.jp/dbget-bin/www_bget?KO:K02335 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Pathway ko03030 http://www.genome.jp/kegg-bin/show_pathway?ko03030 KEGG_Pathway ko03410 http://www.genome.jp/kegg-bin/show_pathway?ko03410 KEGG_Pathway ko03420 http://www.genome.jp/kegg-bin/show_pathway?ko03420 KEGG_Pathway ko03440 http://www.genome.jp/kegg-bin/show_pathway?ko03440 KEGG_Reaction rn:R00375 http://www.genome.jp/dbget-bin/www_bget?rn:R00375 KEGG_Reaction rn:R00376 http://www.genome.jp/dbget-bin/www_bget?rn:R00376 KEGG_Reaction rn:R00377 http://www.genome.jp/dbget-bin/www_bget?rn:R00377 KEGG_Reaction rn:R00378 http://www.genome.jp/dbget-bin/www_bget?rn:R00378 MINT MINT-1225247 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1225247 OMA CFDTETT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CFDTETT PDB 1D8Y http://www.ebi.ac.uk/pdbe-srv/view/entry/1D8Y PDB 1D9D http://www.ebi.ac.uk/pdbe-srv/view/entry/1D9D PDB 1D9F http://www.ebi.ac.uk/pdbe-srv/view/entry/1D9F PDB 1DPI http://www.ebi.ac.uk/pdbe-srv/view/entry/1DPI PDB 1KFD http://www.ebi.ac.uk/pdbe-srv/view/entry/1KFD PDB 1KFS http://www.ebi.ac.uk/pdbe-srv/view/entry/1KFS PDB 1KLN http://www.ebi.ac.uk/pdbe-srv/view/entry/1KLN PDB 1KRP http://www.ebi.ac.uk/pdbe-srv/view/entry/1KRP PDB 1KSP http://www.ebi.ac.uk/pdbe-srv/view/entry/1KSP PDB 1QSL http://www.ebi.ac.uk/pdbe-srv/view/entry/1QSL PDB 2KFN http://www.ebi.ac.uk/pdbe-srv/view/entry/2KFN PDB 2KFZ http://www.ebi.ac.uk/pdbe-srv/view/entry/2KFZ PDB 2KZM http://www.ebi.ac.uk/pdbe-srv/view/entry/2KZM PDB 2KZZ http://www.ebi.ac.uk/pdbe-srv/view/entry/2KZZ PDBsum 1D8Y http://www.ebi.ac.uk/pdbsum/1D8Y PDBsum 1D9D http://www.ebi.ac.uk/pdbsum/1D9D PDBsum 1D9F http://www.ebi.ac.uk/pdbsum/1D9F PDBsum 1DPI http://www.ebi.ac.uk/pdbsum/1DPI PDBsum 1KFD http://www.ebi.ac.uk/pdbsum/1KFD PDBsum 1KFS http://www.ebi.ac.uk/pdbsum/1KFS PDBsum 1KLN http://www.ebi.ac.uk/pdbsum/1KLN PDBsum 1KRP http://www.ebi.ac.uk/pdbsum/1KRP PDBsum 1KSP http://www.ebi.ac.uk/pdbsum/1KSP PDBsum 1QSL http://www.ebi.ac.uk/pdbsum/1QSL PDBsum 2KFN http://www.ebi.ac.uk/pdbsum/2KFN PDBsum 2KFZ http://www.ebi.ac.uk/pdbsum/2KFZ PDBsum 2KZM http://www.ebi.ac.uk/pdbsum/2KZM PDBsum 2KZZ http://www.ebi.ac.uk/pdbsum/2KZZ PRINTS PR00868 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00868 PROSITE PS00447 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00447 PSORT swissprot:DPO1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DPO1_ECOLI PSORT-B swissprot:DPO1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DPO1_ECOLI PSORT2 swissprot:DPO1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DPO1_ECOLI Pfam PF00476 http://pfam.xfam.org/family/PF00476 Pfam PF01367 http://pfam.xfam.org/family/PF01367 Pfam PF01612 http://pfam.xfam.org/family/PF01612 Pfam PF02739 http://pfam.xfam.org/family/PF02739 Phobius swissprot:DPO1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DPO1_ECOLI PhylomeDB P00582 http://phylomedb.org/?seqid=P00582 ProteinModelPortal P00582 http://www.proteinmodelportal.org/query/uniprot/P00582 PubMed 10588690 http://www.ncbi.nlm.nih.gov/pubmed/10588690 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1989886 http://www.ncbi.nlm.nih.gov/pubmed/1989886 PubMed 3883192 http://www.ncbi.nlm.nih.gov/pubmed/3883192 PubMed 6183253 http://www.ncbi.nlm.nih.gov/pubmed/6183253 PubMed 6276402 http://www.ncbi.nlm.nih.gov/pubmed/6276402 PubMed 6302278 http://www.ncbi.nlm.nih.gov/pubmed/6302278 PubMed 7035456 http://www.ncbi.nlm.nih.gov/pubmed/7035456 PubMed 8260491 http://www.ncbi.nlm.nih.gov/pubmed/8260491 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 8442659 http://www.ncbi.nlm.nih.gov/pubmed/8442659 PubMed 8469987 http://www.ncbi.nlm.nih.gov/pubmed/8469987 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9514742 http://www.ncbi.nlm.nih.gov/pubmed/9514742 PubMed 9888810 http://www.ncbi.nlm.nih.gov/pubmed/9888810 RefSeq NP_418300 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418300 RefSeq WP_000250006 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000250006 SMART SM00279 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00279 SMART SM00474 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00474 SMART SM00475 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00475 SMART SM00482 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00482 SMR P00582 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00582 STRING 511145.b3863 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3863&targetmode=cogs STRING COG0258 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0258&targetmode=cogs STRING COG0749 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0749&targetmode=cogs SUPFAM SSF47807 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47807 SUPFAM SSF53098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098 SUPFAM SSF88723 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF88723 SWISS-2DPAGE P00582 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P00582 TIGRFAMs TIGR00593 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00593 UniProtKB DPO1_ECOLI http://www.uniprot.org/uniprot/DPO1_ECOLI UniProtKB-AC P00582 http://www.uniprot.org/uniprot/P00582 charge swissprot:DPO1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DPO1_ECOLI eggNOG COG0258 http://eggnogapi.embl.de/nog_data/html/tree/COG0258 eggNOG COG0749 http://eggnogapi.embl.de/nog_data/html/tree/COG0749 eggNOG ENOG4105C2M http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C2M epestfind swissprot:DPO1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DPO1_ECOLI garnier swissprot:DPO1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DPO1_ECOLI helixturnhelix swissprot:DPO1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DPO1_ECOLI hmoment swissprot:DPO1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DPO1_ECOLI iep swissprot:DPO1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DPO1_ECOLI inforesidue swissprot:DPO1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DPO1_ECOLI octanol swissprot:DPO1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DPO1_ECOLI pepcoil swissprot:DPO1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DPO1_ECOLI pepdigest swissprot:DPO1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DPO1_ECOLI pepinfo swissprot:DPO1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DPO1_ECOLI pepnet swissprot:DPO1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DPO1_ECOLI pepstats swissprot:DPO1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DPO1_ECOLI pepwheel swissprot:DPO1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DPO1_ECOLI pepwindow swissprot:DPO1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DPO1_ECOLI sigcleave swissprot:DPO1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DPO1_ECOLI ## Database ID URL or Descriptions # BioGrid 4259823 7 # CDD cd06261 TM_PBP2 # EcoGene EG13301 tauC # FUNCTION TAUC_ECOLI Part of a binding-protein-dependent transport system for taurine. Probably responsible for the translocation of the substrate across the membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005215 transporter activity; IBA:GO_Central. # GO_process GO:0010438 cellular response to sulfur starvation; IEP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006950 response to stress # Gene3D 1.10.3720.10 -; 1. # InterPro IPR000515 MetI-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00435 Taurine transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism TAUC_ECOLI Escherichia coli (strain K12) # PATRIC 32115873 VBIEscCol129921_0378 # PIR S78606 S78606 # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TAUC_ECOLI Taurine transport system permease protein TauC # RefSeq NP_414901 NC_000913.3 # RefSeq WP_000114620 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION TAUC_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00441, ECO 0000269|PubMed 15919996}. # SUPFAM SSF161098 SSF161098 # TCDB 3.A.1.17 the atp-binding cassette (abc) superfamily # eggNOG COG0600 LUCA # eggNOG ENOG4105EUS Bacteria BLAST swissprot:TAUC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TAUC_ECOLI BioCyc ECOL316407:JW0359-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0359-MONOMER BioCyc EcoCyc:TAUC-MONOMER http://biocyc.org/getid?id=EcoCyc:TAUC-MONOMER BioCyc MetaCyc:TAUC-MONOMER http://biocyc.org/getid?id=MetaCyc:TAUC-MONOMER COG COG0600 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0600 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D85613 http://www.ebi.ac.uk/ena/data/view/D85613 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB3086 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3086 EcoGene EG13301 http://www.ecogene.org/geneInfo.php?eg_id=EG13301 EnsemblBacteria AAC73470 http://www.ensemblgenomes.org/id/AAC73470 EnsemblBacteria AAC73470 http://www.ensemblgenomes.org/id/AAC73470 EnsemblBacteria BAE76148 http://www.ensemblgenomes.org/id/BAE76148 EnsemblBacteria BAE76148 http://www.ensemblgenomes.org/id/BAE76148 EnsemblBacteria BAE76148 http://www.ensemblgenomes.org/id/BAE76148 EnsemblBacteria b0367 http://www.ensemblgenomes.org/id/b0367 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_process GO:0010438 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010438 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 945026 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945026 HOGENOM HOG000134230 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000134230&db=HOGENOM6 InParanoid Q47539 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q47539 InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0359 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0359 KEGG_Gene eco:b0367 http://www.genome.jp/dbget-bin/www_bget?eco:b0367 KEGG_Orthology KO:K15552 http://www.genome.jp/dbget-bin/www_bget?KO:K15552 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA LVPWHGQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LVPWHGQ PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:TAUC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TAUC_ECOLI PSORT-B swissprot:TAUC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TAUC_ECOLI PSORT2 swissprot:TAUC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TAUC_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Phobius swissprot:TAUC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TAUC_ECOLI PhylomeDB Q47539 http://phylomedb.org/?seqid=Q47539 ProteinModelPortal Q47539 http://www.proteinmodelportal.org/query/uniprot/Q47539 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8808933 http://www.ncbi.nlm.nih.gov/pubmed/8808933 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414901 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414901 RefSeq WP_000114620 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000114620 SMR Q47539 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q47539 STRING 511145.b0367 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0367&targetmode=cogs STRING COG0600 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0600&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.17 http://www.tcdb.org/search/result.php?tc=3.A.1.17 UniProtKB TAUC_ECOLI http://www.uniprot.org/uniprot/TAUC_ECOLI UniProtKB-AC Q47539 http://www.uniprot.org/uniprot/Q47539 charge swissprot:TAUC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TAUC_ECOLI eggNOG COG0600 http://eggnogapi.embl.de/nog_data/html/tree/COG0600 eggNOG ENOG4105EUS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EUS epestfind swissprot:TAUC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TAUC_ECOLI garnier swissprot:TAUC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TAUC_ECOLI helixturnhelix swissprot:TAUC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TAUC_ECOLI hmoment swissprot:TAUC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TAUC_ECOLI iep swissprot:TAUC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TAUC_ECOLI inforesidue swissprot:TAUC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TAUC_ECOLI octanol swissprot:TAUC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TAUC_ECOLI pepcoil swissprot:TAUC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TAUC_ECOLI pepdigest swissprot:TAUC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TAUC_ECOLI pepinfo swissprot:TAUC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TAUC_ECOLI pepnet swissprot:TAUC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TAUC_ECOLI pepstats swissprot:TAUC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TAUC_ECOLI pepwheel swissprot:TAUC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TAUC_ECOLI pepwindow swissprot:TAUC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TAUC_ECOLI sigcleave swissprot:TAUC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TAUC_ECOLI ## Database ID URL or Descriptions # BioGrid 4261073 178 # EcoGene EG12668 uidC # FUNCTION UIDC_ECOLI Enhances the activity of the UidB (GusB) glucuronide transporter, on its own however it has no transport activity. Glucuronide transport does not occur in strain K12 due to a variant at position 100 of the UidB (GusB, AC P0CE44, AC P0CE45) protein. {ECO 0000269|PubMed 15774881}. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_component GO:0046930 pore complex; IEA:UniProtKB-KW. # GO_function GO:0015288 porin activity; IEA:UniProtKB-KW. # GO_process GO:0006811 ion transport; IEA:UniProtKB-KW. # GO_process GO:0008643 carbohydrate transport; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043234 protein complex # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # Gene3D 2.40.160.10 -; 1. # INDUCTION In the presence of glucuronides. {ECO:0000269|PubMed 15774881}. # IntAct Q47706 6 # InterPro IPR005318 OM_porin_bac # InterPro IPR023614 Porin_dom # KEGG_Brite ko02000 Transporters # Organism UIDC_ECOLI Escherichia coli (strain K12) # PATRIC 32118532 VBIEscCol129921_1686 # PIR A64918 A64918 # Pfam PF03573 OprD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UIDC_ECOLI Membrane-associated protein UidC # RefSeq NP_416132 NC_000913.3 # RefSeq WP_001227023 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA68925.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the outer membrane porin (Opr) (TC 1.B.25) family. {ECO 0000305}. # SUBCELLULAR LOCATION UIDC_ECOLI Cell outer membrane {ECO 0000269|PubMed 15774881}. # TCDB 1.B.25.1 the outer membrane porin (opr) family # eggNOG ENOG4108QNI Bacteria # eggNOG ENOG410XU8G LUCA BLAST swissprot:UIDC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UIDC_ECOLI BioCyc ECOL316407:JW1607-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1607-MONOMER BioCyc EcoCyc:G6866-MONOMER http://biocyc.org/getid?id=EcoCyc:G6866-MONOMER DIP DIP-11088N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11088N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.187.7.2377-2385.2005 http://dx.doi.org/10.1128/JB.187.7.2377-2385.2005 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M14641 http://www.ebi.ac.uk/ena/data/view/M14641 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2534 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2534 EcoGene EG12668 http://www.ecogene.org/geneInfo.php?eg_id=EG12668 EnsemblBacteria AAC74687 http://www.ensemblgenomes.org/id/AAC74687 EnsemblBacteria AAC74687 http://www.ensemblgenomes.org/id/AAC74687 EnsemblBacteria BAE76482 http://www.ensemblgenomes.org/id/BAE76482 EnsemblBacteria BAE76482 http://www.ensemblgenomes.org/id/BAE76482 EnsemblBacteria BAE76482 http://www.ensemblgenomes.org/id/BAE76482 EnsemblBacteria b1615 http://www.ensemblgenomes.org/id/b1615 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0046930 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046930 GO_function GO:0015288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015288 GO_process GO:0006811 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811 GO_process GO:0008643 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008643 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 2.40.160.10 http://www.cathdb.info/version/latest/superfamily/2.40.160.10 GeneID 944820 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944820 HOGENOM HOG000120875 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120875&db=HOGENOM6 IntAct Q47706 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q47706* InterPro IPR005318 http://www.ebi.ac.uk/interpro/entry/IPR005318 InterPro IPR023614 http://www.ebi.ac.uk/interpro/entry/IPR023614 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1607 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1607 KEGG_Gene eco:b1615 http://www.genome.jp/dbget-bin/www_bget?eco:b1615 KEGG_Orthology KO:K16140 http://www.genome.jp/dbget-bin/www_bget?KO:K16140 MINT MINT-1299860 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1299860 OMA YDAILYY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YDAILYY PSORT swissprot:UIDC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UIDC_ECOLI PSORT-B swissprot:UIDC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UIDC_ECOLI PSORT2 swissprot:UIDC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UIDC_ECOLI Pfam PF03573 http://pfam.xfam.org/family/PF03573 Phobius swissprot:UIDC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UIDC_ECOLI ProteinModelPortal Q47706 http://www.proteinmodelportal.org/query/uniprot/Q47706 PubMed 15774881 http://www.ncbi.nlm.nih.gov/pubmed/15774881 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416132 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416132 RefSeq WP_001227023 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001227023 STRING 511145.b1615 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1615&targetmode=cogs TCDB 1.B.25.1 http://www.tcdb.org/search/result.php?tc=1.B.25.1 UniProtKB UIDC_ECOLI http://www.uniprot.org/uniprot/UIDC_ECOLI UniProtKB-AC Q47706 http://www.uniprot.org/uniprot/Q47706 charge swissprot:UIDC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UIDC_ECOLI eggNOG ENOG4108QNI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108QNI eggNOG ENOG410XU8G http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XU8G epestfind swissprot:UIDC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UIDC_ECOLI garnier swissprot:UIDC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UIDC_ECOLI helixturnhelix swissprot:UIDC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UIDC_ECOLI hmoment swissprot:UIDC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UIDC_ECOLI iep swissprot:UIDC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UIDC_ECOLI inforesidue swissprot:UIDC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UIDC_ECOLI octanol swissprot:UIDC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UIDC_ECOLI pepcoil swissprot:UIDC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UIDC_ECOLI pepdigest swissprot:UIDC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UIDC_ECOLI pepinfo swissprot:UIDC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UIDC_ECOLI pepnet swissprot:UIDC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UIDC_ECOLI pepstats swissprot:UIDC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UIDC_ECOLI pepwheel swissprot:UIDC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UIDC_ECOLI pepwindow swissprot:UIDC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UIDC_ECOLI sigcleave swissprot:UIDC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UIDC_ECOLI ## Database ID URL or Descriptions # BioGrid 4259421 213 # DISRUPTION PHENOTYPE Allows basal levels of poly-GlcNAc synthesis and biofilm formation; serves as a model system for biofilm formation. {ECO:0000269|PubMed 19460094}. # EcoGene EG11447 csrA # FUNCTION CSRA_ECOLI Binds to mRNA to regulate post-transcriptional activity. Affects glycogen biosynthesis, gluconeogenesis, cell size and surface properties. Regulates glycogen synthesis under both aerobic and anaerobic conditions. Seems to accelerate the degradation of glg gene transcripts, potentially through selective RNA binding. Acts to inhibit interaction between the LetD protein and the A subunit of DNA gyrase. Also required for motility and flagellum biosynthesis through the post-transcriptional activation of flhDC expression. This involves binding to and stabilization of the flhDC message by CsrA. Binds to and reduces levels of probable diguanylate cyclases ycdT and ydeH. {ECO 0000269|PubMed 11298291, ECO 0000269|PubMed 18713317, ECO 0000269|PubMed 19460094}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0048027 mRNA 5'-UTR binding; IDA:EcoCyc. # GO_process GO:0006402 mRNA catabolic process; IEA:UniProtKB-HAMAP. # GO_process GO:0045719 negative regulation of glycogen biosynthetic process; IDA:EcoCyc. # GO_process GO:0045947 negative regulation of translational initiation; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003729 mRNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # HAMAP MF_00167 CsrA # INDUCTION CSRA_ECOLI Activated by MqsR. {ECO 0000269|PubMed 16352847, ECO 0000269|PubMed 18713317}. # IntAct P69913 8 # InterPro IPR003751 CsrA # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko02020 Two-component system # Organism CSRA_ECOLI Escherichia coli (strain K12) # PATRIC 32120786 VBIEscCol129921_2785 # PDB 1Y00 NMR; -; A/B=1-61 # PIR B40608 B40608 # Pfam PF02599 CsrA # ProDom PD009007 CsrA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CSRA_ECOLI Carbon storage regulator # RefSeq NP_417176 NC_000913.3 # RefSeq WP_000906486 NZ_LN832404.1 # SIMILARITY Belongs to the CsrA family. {ECO 0000305}. # SUBUNIT Homodimer. Binds to and is sequestered by the non-coding RNAs CsrB and CsrC which antagonize the activity of CsrA. {ECO:0000269|PubMed 15866937}. # TIGRFAMs TIGR00202 csrA # eggNOG COG1551 LUCA BLAST swissprot:CSRA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CSRA_ECOLI BioCyc ECOL316407:JW2666-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2666-MONOMER BioCyc EcoCyc:EG11447-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11447-MONOMER COG COG1551 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1551 DIP DIP-47836N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47836N DOI 10.1006/jmbi.1996.0103 http://dx.doi.org/10.1006/jmbi.1996.0103 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2001.02380.x http://dx.doi.org/10.1046/j.1365-2958.2001.02380.x DOI 10.1074/jbc.272.28.17502 http://dx.doi.org/10.1074/jbc.272.28.17502 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1365-2958.2008.06411.x http://dx.doi.org/10.1111/j.1365-2958.2008.06411.x DOI 10.1111/j.1365-2958.2009.06739.x http://dx.doi.org/10.1111/j.1365-2958.2009.06739.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.187.10.3496-3501.2005 http://dx.doi.org/10.1128/JB.187.10.3496-3501.2005 DOI 10.1128/JB.188.1.305-316.2006 http://dx.doi.org/10.1128/JB.188.1.305-316.2006 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D44453 http://www.ebi.ac.uk/ena/data/view/D44453 EMBL L07596 http://www.ebi.ac.uk/ena/data/view/L07596 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1416 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1416 EcoGene EG11447 http://www.ecogene.org/geneInfo.php?eg_id=EG11447 EnsemblBacteria AAC75738 http://www.ensemblgenomes.org/id/AAC75738 EnsemblBacteria AAC75738 http://www.ensemblgenomes.org/id/AAC75738 EnsemblBacteria BAA16558 http://www.ensemblgenomes.org/id/BAA16558 EnsemblBacteria BAA16558 http://www.ensemblgenomes.org/id/BAA16558 EnsemblBacteria BAA16558 http://www.ensemblgenomes.org/id/BAA16558 EnsemblBacteria b2696 http://www.ensemblgenomes.org/id/b2696 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0048027 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048027 GO_process GO:0006402 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006402 GO_process GO:0045719 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045719 GO_process GO:0045947 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045947 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003729 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003729 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 GeneID 5551697 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5551697 GeneID 947176 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947176 HAMAP MF_00167 http://hamap.expasy.org/unirule/MF_00167 HOGENOM HOG000020767 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000020767&db=HOGENOM6 InParanoid P69913 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P69913 IntAct P69913 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69913* InterPro IPR003751 http://www.ebi.ac.uk/interpro/entry/IPR003751 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW2666 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2666 KEGG_Gene eco:b2696 http://www.genome.jp/dbget-bin/www_bget?eco:b2696 KEGG_Orthology KO:K03563 http://www.genome.jp/dbget-bin/www_bget?KO:K03563 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 MINT MINT-1317679 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1317679 OMA IYARIQR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IYARIQR PDB 1Y00 http://www.ebi.ac.uk/pdbe-srv/view/entry/1Y00 PDBsum 1Y00 http://www.ebi.ac.uk/pdbsum/1Y00 PSORT swissprot:CSRA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CSRA_ECOLI PSORT-B swissprot:CSRA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CSRA_ECOLI PSORT2 swissprot:CSRA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CSRA_ECOLI Pfam PF02599 http://pfam.xfam.org/family/PF02599 Phobius swissprot:CSRA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CSRA_ECOLI PhylomeDB P69913 http://phylomedb.org/?seqid=P69913 ProteinModelPortal P69913 http://www.proteinmodelportal.org/query/uniprot/P69913 PubMed 11298291 http://www.ncbi.nlm.nih.gov/pubmed/11298291 PubMed 15866937 http://www.ncbi.nlm.nih.gov/pubmed/15866937 PubMed 16352847 http://www.ncbi.nlm.nih.gov/pubmed/16352847 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18713317 http://www.ncbi.nlm.nih.gov/pubmed/18713317 PubMed 19460094 http://www.ncbi.nlm.nih.gov/pubmed/19460094 PubMed 7751274 http://www.ncbi.nlm.nih.gov/pubmed/7751274 PubMed 8393005 http://www.ncbi.nlm.nih.gov/pubmed/8393005 PubMed 8604133 http://www.ncbi.nlm.nih.gov/pubmed/8604133 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9211896 http://www.ncbi.nlm.nih.gov/pubmed/9211896 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417176 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417176 RefSeq WP_000906486 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000906486 SMR P69913 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69913 STRING 511145.b2696 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2696&targetmode=cogs STRING COG1551 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1551&targetmode=cogs TIGRFAMs TIGR00202 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00202 UniProtKB CSRA_ECOLI http://www.uniprot.org/uniprot/CSRA_ECOLI UniProtKB-AC P69913 http://www.uniprot.org/uniprot/P69913 charge swissprot:CSRA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CSRA_ECOLI eggNOG COG1551 http://eggnogapi.embl.de/nog_data/html/tree/COG1551 epestfind swissprot:CSRA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CSRA_ECOLI garnier swissprot:CSRA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CSRA_ECOLI helixturnhelix swissprot:CSRA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CSRA_ECOLI hmoment swissprot:CSRA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CSRA_ECOLI iep swissprot:CSRA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CSRA_ECOLI inforesidue swissprot:CSRA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CSRA_ECOLI octanol swissprot:CSRA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CSRA_ECOLI pepcoil swissprot:CSRA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CSRA_ECOLI pepdigest swissprot:CSRA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CSRA_ECOLI pepinfo swissprot:CSRA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CSRA_ECOLI pepnet swissprot:CSRA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CSRA_ECOLI pepstats swissprot:CSRA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CSRA_ECOLI pepwheel swissprot:CSRA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CSRA_ECOLI pepwindow swissprot:CSRA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CSRA_ECOLI sigcleave swissprot:CSRA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CSRA_ECOLI ## Database ID URL or Descriptions # AltName SYQ_ECOLI Glutaminyl-tRNA synthetase # BRENDA 6.1.1.18 2026 # BRENDA 6.1.1.24 2026 # BioGrid 4261207 7 # CATALYTIC ACTIVITY SYQ_ECOLI ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln). # EcoGene EG10390 glnS # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003723 RNA binding; IBA:GO_Central. # GO_function GO:0004819 glutamine-tRNA ligase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006424 glutamyl-tRNA aminoacylation; IEA:UniProtKB-HAMAP. # GO_process GO:0006425 glutaminyl-tRNA aminoacylation; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0006520 cellular amino acid metabolic process # Gene3D 1.10.1160.10 -; 1. # Gene3D 2.40.240.10 -; 2. # Gene3D 3.40.50.620 -; 2. # HAMAP MF_00126 Gln_tRNA_synth # IntAct P00962 5 # InterPro IPR000924 Glu/Gln-tRNA-synth # InterPro IPR001412 aa-tRNA-synth_I_CS # InterPro IPR004514 Gln-tRNA-synth # InterPro IPR011035 Ribosomal_L25/Gln-tRNA_synth # InterPro IPR014729 Rossmann-like_a/b/a_fold # InterPro IPR020056 Rbsml_L25/Gln-tRNA_synth_b-brl # InterPro IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom # InterPro IPR020059 Glu/Gln-tRNA-synth_Ib_codon-bd # InterPro IPR020061 Glu/Gln-tRNA-synth_Ib_a-bdl # InterPro IPR022861 Gln_tRNA_ligase_bac # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01007 Amino acid related enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # KEGG_Pathway ko00970 Aminoacyl-tRNA biosynthesis # Organism SYQ_ECOLI Escherichia coli (strain K12) # PATRIC 32116549 VBIEscCol129921_0707 # PDB 1EUQ X-ray; 3.10 A; A=1-548 # PDB 1EUY X-ray; 2.60 A; A=1-548 # PDB 1EXD X-ray; 2.70 A; A=1-548 # PDB 1GSG X-ray; 2.80 A; P=2-554 # PDB 1GTR X-ray; 2.50 A; A=2-554 # PDB 1GTS X-ray; 2.80 A; A=2-554 # PDB 1NYL X-ray; 2.60 A; A=9-547 # PDB 1O0B X-ray; 2.70 A; A=2-554 # PDB 1O0C X-ray; 2.70 A; A=2-554 # PDB 1QRS X-ray; 2.60 A; A=2-554 # PDB 1QRT X-ray; 2.70 A; A=2-554 # PDB 1QRU X-ray; 3.00 A; A=2-554 # PDB 1QTQ X-ray; 2.25 A; A=2-554 # PDB 1ZJW X-ray; 2.50 A; A=2-554 # PDB 2RD2 X-ray; 2.60 A; A=1-548 # PDB 2RE8 X-ray; 2.60 A; A=1-548 # PDB 4JXX X-ray; 2.30 A; A=2-554 # PDB 4JXZ X-ray; 2.40 A; A=2-554 # PDB 4JYZ X-ray; 2.50 A; A=2-554 # PIR G64802 SYECQT # PIR I41235 I41235 # PRINTS PR00987 TRNASYNTHGLU # PROSITE PS00178 AA_TRNA_LIGASE_I # Pfam PF00749 tRNA-synt_1c # Pfam PF03950 tRNA-synt_1c_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SYQ_ECOLI Glutamine--tRNA ligase # RefSeq NP_415206 NC_000913.3 # RefSeq WP_001287154 NZ_LN832404.1 # SIMILARITY Belongs to the class-I aminoacyl-tRNA synthetase family. {ECO 0000305}. # SUBCELLULAR LOCATION SYQ_ECOLI Cytoplasm. # SUBUNIT SYQ_ECOLI Monomer. # SUPFAM SSF50715 SSF50715 # TIGRFAMs TIGR00440 glnS # eggNOG COG0008 LUCA # eggNOG ENOG4105CX6 Bacteria BLAST swissprot:SYQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SYQ_ECOLI BioCyc ECOL316407:JW0666-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0666-MONOMER BioCyc EcoCyc:GLNS-MONOMER http://biocyc.org/getid?id=EcoCyc:GLNS-MONOMER BioCyc MetaCyc:GLNS-MONOMER http://biocyc.org/getid?id=MetaCyc:GLNS-MONOMER COG COG0008 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0008 DIP DIP-9787N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9787N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.2000.3749 http://dx.doi.org/10.1006/jmbi.2000.3749 DOI 10.1016/S0969-2126(98)00046-X http://dx.doi.org/10.1016/S0969-2126(98)00046-X DOI 10.1038/352213a0 http://dx.doi.org/10.1038/352213a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.2479982 http://dx.doi.org/10.1126/science.2479982 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.1.1.18 http://www.genome.jp/dbget-bin/www_bget?EC:6.1.1.18 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M16368 http://www.ebi.ac.uk/ena/data/view/M16368 EMBL M16470 http://www.ebi.ac.uk/ena/data/view/M16470 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V01575 http://www.ebi.ac.uk/ena/data/view/V01575 ENZYME 6.1.1.18 http://enzyme.expasy.org/EC/6.1.1.18 EchoBASE EB0385 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0385 EcoGene EG10390 http://www.ecogene.org/geneInfo.php?eg_id=EG10390 EnsemblBacteria AAC73774 http://www.ensemblgenomes.org/id/AAC73774 EnsemblBacteria AAC73774 http://www.ensemblgenomes.org/id/AAC73774 EnsemblBacteria BAA35328 http://www.ensemblgenomes.org/id/BAA35328 EnsemblBacteria BAA35328 http://www.ensemblgenomes.org/id/BAA35328 EnsemblBacteria BAA35328 http://www.ensemblgenomes.org/id/BAA35328 EnsemblBacteria b0680 http://www.ensemblgenomes.org/id/b0680 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0004819 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004819 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006424 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006424 GO_process GO:0006425 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006425 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 Gene3D 1.10.1160.10 http://www.cathdb.info/version/latest/superfamily/1.10.1160.10 Gene3D 2.40.240.10 http://www.cathdb.info/version/latest/superfamily/2.40.240.10 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 GeneID 945310 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945310 HAMAP MF_00126 http://hamap.expasy.org/unirule/MF_00126 HOGENOM HOG000259232 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000259232&db=HOGENOM6 InParanoid P00962 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00962 IntAct P00962 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00962* IntEnz 6.1.1.18 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.1.1.18 InterPro IPR000924 http://www.ebi.ac.uk/interpro/entry/IPR000924 InterPro IPR001412 http://www.ebi.ac.uk/interpro/entry/IPR001412 InterPro IPR004514 http://www.ebi.ac.uk/interpro/entry/IPR004514 InterPro IPR011035 http://www.ebi.ac.uk/interpro/entry/IPR011035 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 InterPro IPR020056 http://www.ebi.ac.uk/interpro/entry/IPR020056 InterPro IPR020058 http://www.ebi.ac.uk/interpro/entry/IPR020058 InterPro IPR020059 http://www.ebi.ac.uk/interpro/entry/IPR020059 InterPro IPR020061 http://www.ebi.ac.uk/interpro/entry/IPR020061 InterPro IPR022861 http://www.ebi.ac.uk/interpro/entry/IPR022861 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW0666 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0666 KEGG_Gene eco:b0680 http://www.genome.jp/dbget-bin/www_bget?eco:b0680 KEGG_Orthology KO:K01886 http://www.genome.jp/dbget-bin/www_bget?KO:K01886 KEGG_Pathway ko00970 http://www.genome.jp/kegg-bin/show_pathway?ko00970 KEGG_Reaction rn:R03652 http://www.genome.jp/dbget-bin/www_bget?rn:R03652 MINT MINT-1227909 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1227909 OMA HCTYDPE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HCTYDPE PDB 1EUQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1EUQ PDB 1EUY http://www.ebi.ac.uk/pdbe-srv/view/entry/1EUY PDB 1EXD http://www.ebi.ac.uk/pdbe-srv/view/entry/1EXD PDB 1GSG http://www.ebi.ac.uk/pdbe-srv/view/entry/1GSG PDB 1GTR http://www.ebi.ac.uk/pdbe-srv/view/entry/1GTR PDB 1GTS http://www.ebi.ac.uk/pdbe-srv/view/entry/1GTS PDB 1NYL http://www.ebi.ac.uk/pdbe-srv/view/entry/1NYL PDB 1O0B http://www.ebi.ac.uk/pdbe-srv/view/entry/1O0B PDB 1O0C http://www.ebi.ac.uk/pdbe-srv/view/entry/1O0C PDB 1QRS http://www.ebi.ac.uk/pdbe-srv/view/entry/1QRS PDB 1QRT http://www.ebi.ac.uk/pdbe-srv/view/entry/1QRT PDB 1QRU http://www.ebi.ac.uk/pdbe-srv/view/entry/1QRU PDB 1QTQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1QTQ PDB 1ZJW http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZJW PDB 2RD2 http://www.ebi.ac.uk/pdbe-srv/view/entry/2RD2 PDB 2RE8 http://www.ebi.ac.uk/pdbe-srv/view/entry/2RE8 PDB 4JXX http://www.ebi.ac.uk/pdbe-srv/view/entry/4JXX PDB 4JXZ http://www.ebi.ac.uk/pdbe-srv/view/entry/4JXZ PDB 4JYZ http://www.ebi.ac.uk/pdbe-srv/view/entry/4JYZ PDBsum 1EUQ http://www.ebi.ac.uk/pdbsum/1EUQ PDBsum 1EUY http://www.ebi.ac.uk/pdbsum/1EUY PDBsum 1EXD http://www.ebi.ac.uk/pdbsum/1EXD PDBsum 1GSG http://www.ebi.ac.uk/pdbsum/1GSG PDBsum 1GTR http://www.ebi.ac.uk/pdbsum/1GTR PDBsum 1GTS http://www.ebi.ac.uk/pdbsum/1GTS PDBsum 1NYL http://www.ebi.ac.uk/pdbsum/1NYL PDBsum 1O0B http://www.ebi.ac.uk/pdbsum/1O0B PDBsum 1O0C http://www.ebi.ac.uk/pdbsum/1O0C PDBsum 1QRS http://www.ebi.ac.uk/pdbsum/1QRS PDBsum 1QRT http://www.ebi.ac.uk/pdbsum/1QRT PDBsum 1QRU http://www.ebi.ac.uk/pdbsum/1QRU PDBsum 1QTQ http://www.ebi.ac.uk/pdbsum/1QTQ PDBsum 1ZJW http://www.ebi.ac.uk/pdbsum/1ZJW PDBsum 2RD2 http://www.ebi.ac.uk/pdbsum/2RD2 PDBsum 2RE8 http://www.ebi.ac.uk/pdbsum/2RE8 PDBsum 4JXX http://www.ebi.ac.uk/pdbsum/4JXX PDBsum 4JXZ http://www.ebi.ac.uk/pdbsum/4JXZ PDBsum 4JYZ http://www.ebi.ac.uk/pdbsum/4JYZ PRINTS PR00987 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00987 PROSITE PS00178 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00178 PSORT swissprot:SYQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SYQ_ECOLI PSORT-B swissprot:SYQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SYQ_ECOLI PSORT2 swissprot:SYQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SYQ_ECOLI Pfam PF00749 http://pfam.xfam.org/family/PF00749 Pfam PF03950 http://pfam.xfam.org/family/PF03950 Phobius swissprot:SYQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SYQ_ECOLI PhylomeDB P00962 http://phylomedb.org/?seqid=P00962 ProteinModelPortal P00962 http://www.proteinmodelportal.org/query/uniprot/P00962 PubMed 10860750 http://www.ncbi.nlm.nih.gov/pubmed/10860750 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1857417 http://www.ncbi.nlm.nih.gov/pubmed/1857417 PubMed 2464170 http://www.ncbi.nlm.nih.gov/pubmed/2464170 PubMed 2479982 http://www.ncbi.nlm.nih.gov/pubmed/2479982 PubMed 6288695 http://www.ncbi.nlm.nih.gov/pubmed/6288695 PubMed 6389180 http://www.ncbi.nlm.nih.gov/pubmed/6389180 PubMed 6749844 http://www.ncbi.nlm.nih.gov/pubmed/6749844 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9562563 http://www.ncbi.nlm.nih.gov/pubmed/9562563 RefSeq NP_415206 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415206 RefSeq WP_001287154 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001287154 SMR P00962 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00962 STRING 511145.b0680 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0680&targetmode=cogs STRING COG0008 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0008&targetmode=cogs SUPFAM SSF50715 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50715 SWISS-2DPAGE P00962 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P00962 TIGRFAMs TIGR00440 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00440 UniProtKB SYQ_ECOLI http://www.uniprot.org/uniprot/SYQ_ECOLI UniProtKB-AC P00962 http://www.uniprot.org/uniprot/P00962 charge swissprot:SYQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SYQ_ECOLI eggNOG COG0008 http://eggnogapi.embl.de/nog_data/html/tree/COG0008 eggNOG ENOG4105CX6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CX6 epestfind swissprot:SYQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SYQ_ECOLI garnier swissprot:SYQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SYQ_ECOLI helixturnhelix swissprot:SYQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SYQ_ECOLI hmoment swissprot:SYQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SYQ_ECOLI iep swissprot:SYQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SYQ_ECOLI inforesidue swissprot:SYQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SYQ_ECOLI octanol swissprot:SYQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SYQ_ECOLI pepcoil swissprot:SYQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SYQ_ECOLI pepdigest swissprot:SYQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SYQ_ECOLI pepinfo swissprot:SYQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SYQ_ECOLI pepnet swissprot:SYQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SYQ_ECOLI pepstats swissprot:SYQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SYQ_ECOLI pepwheel swissprot:SYQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SYQ_ECOLI pepwindow swissprot:SYQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SYQ_ECOLI sigcleave swissprot:SYQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SYQ_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=140 uM for ATP {ECO 0000269|PubMed:8762140}; # BioGrid 4263458 73 # CATALYTIC ACTIVITY RBSA_ECOLI ATP + H(2)O + monosaccharide(Out) = ADP + phosphate + monosaccharide(In). {ECO 0000255|HAMAP-Rule MF_01716, ECO 0000305|PubMed 8762140}. # EcoGene EG10814 rbsA # FUNCTION RBSA_ECOLI Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system. {ECO 0000255|HAMAP-Rule MF_01716, ECO 0000269|PubMed 25533465, ECO 0000269|PubMed 6327617, ECO 0000269|PubMed 8762140}. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IEA:UniProtKB-HAMAP. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0015407 monosaccharide-transporting ATPase activity; IEA:UniProtKB-EC. # GO_function GO:0015591 D-ribose transmembrane transporter activity; IEA:UniProtKB-HAMAP. # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.300 -; 2. # INTERACTION RBSA_ECOLI P16685 phnG; NbExp=3; IntAct=EBI-1132449, EBI-9126715; # IntAct P04983 11 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR015861 ABC_transpr_RbsA # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00212 Ribose transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism RBSA_ECOLI Escherichia coli (strain K12) # PATRIC 32122997 VBIEscCol129921_3874 # PIR B26304 B26304 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # PROSITE PS51254 RBSA # Pfam PF00005 ABC_tran; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Ribose import ATP-binding protein RbsA {ECO:0000255|HAMAP-Rule MF_01716, ECO:0000305} # RefSeq NP_418205 NC_000913.3 # RefSeq WP_000387770 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family. {ECO:0000255|HAMAP-Rule MF_01716}. # SIMILARITY Contains 2 ABC transporter domains. {ECO:0000255|HAMAP-Rule MF_01716}. # SMART SM00382 AAA; 2 # SUBCELLULAR LOCATION RBSA_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01716, ECO 0000305|PubMed 25533465}; Peripheral membrane protein {ECO 0000255|HAMAP-Rule MF_01716, ECO 0000305|PubMed 25533465}. # SUBUNIT RBSA_ECOLI The complex is composed of an ATP-binding protein (RbsA), two transmembrane proteins (RbsC) and a solute-binding protein (RbsB). {ECO 0000255|HAMAP-Rule MF_01716, ECO 0000269|PubMed 25533465}. # SUPFAM SSF52540 SSF52540; 2 # TCDB 3.A.1.2 the atp-binding cassette (abc) superfamily # eggNOG COG1129 LUCA # eggNOG ENOG4105C2J Bacteria BLAST swissprot:RBSA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RBSA_ECOLI BioCyc ECOL316407:JW3728-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3728-MONOMER BioCyc EcoCyc:RBSA-MONOMER http://biocyc.org/getid?id=EcoCyc:RBSA-MONOMER BioCyc MetaCyc:RBSA-MONOMER http://biocyc.org/getid?id=MetaCyc:RBSA-MONOMER COG COG1129 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1129 DIP DIP-10640N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10640N DOI 10.1002/pro.5560050611 http://dx.doi.org/10.1002/pro.5560050611 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M114.621573 http://dx.doi.org/10.1074/jbc.M114.621573 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.3.17 {ECO:0000255|HAMAP-Rule:MF_01716, ECO:0000305|PubMed:8762140} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.17 {ECO:0000255|HAMAP-Rule:MF_01716, ECO:0000305|PubMed:8762140} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M13169 http://www.ebi.ac.uk/ena/data/view/M13169 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.6.3.17 {ECO:0000255|HAMAP-Rule:MF_01716, ECO:0000305|PubMed:8762140} http://enzyme.expasy.org/EC/3.6.3.17 {ECO:0000255|HAMAP-Rule:MF_01716, ECO:0000305|PubMed:8762140} EchoBASE EB0807 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0807 EcoGene EG10814 http://www.ecogene.org/geneInfo.php?eg_id=EG10814 EnsemblBacteria AAC76772 http://www.ensemblgenomes.org/id/AAC76772 EnsemblBacteria AAC76772 http://www.ensemblgenomes.org/id/AAC76772 EnsemblBacteria BAE77539 http://www.ensemblgenomes.org/id/BAE77539 EnsemblBacteria BAE77539 http://www.ensemblgenomes.org/id/BAE77539 EnsemblBacteria BAE77539 http://www.ensemblgenomes.org/id/BAE77539 EnsemblBacteria b3749 http://www.ensemblgenomes.org/id/b3749 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0015407 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015407 GO_function GO:0015591 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015591 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948264 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948264 InParanoid P04983 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P04983 IntAct P04983 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P04983* IntEnz 3.6.3.17 {ECO:0000255|HAMAP-Rule:MF_01716, ECO:0000305|PubMed:8762140} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.17 {ECO:0000255|HAMAP-Rule:MF_01716, ECO:0000305|PubMed:8762140} InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR015861 http://www.ebi.ac.uk/interpro/entry/IPR015861 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3728 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3728 KEGG_Gene eco:b3749 http://www.genome.jp/dbget-bin/www_bget?eco:b3749 KEGG_Orthology KO:K10441 http://www.genome.jp/dbget-bin/www_bget?KO:K10441 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA MDNMERI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MDNMERI PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PROSITE PS51254 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51254 PSORT swissprot:RBSA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RBSA_ECOLI PSORT-B swissprot:RBSA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RBSA_ECOLI PSORT2 swissprot:RBSA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RBSA_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Phobius swissprot:RBSA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RBSA_ECOLI PhylomeDB P04983 http://phylomedb.org/?seqid=P04983 ProteinModelPortal P04983 http://www.proteinmodelportal.org/query/uniprot/P04983 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 25533465 http://www.ncbi.nlm.nih.gov/pubmed/25533465 PubMed 3011793 http://www.ncbi.nlm.nih.gov/pubmed/3011793 PubMed 3086314 http://www.ncbi.nlm.nih.gov/pubmed/3086314 PubMed 6327617 http://www.ncbi.nlm.nih.gov/pubmed/6327617 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 8762140 http://www.ncbi.nlm.nih.gov/pubmed/8762140 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418205 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418205 RefSeq WP_000387770 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000387770 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P04983 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P04983 STRING 511145.b3749 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3749&targetmode=cogs STRING COG1129 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1129&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.2 http://www.tcdb.org/search/result.php?tc=3.A.1.2 UniProtKB RBSA_ECOLI http://www.uniprot.org/uniprot/RBSA_ECOLI UniProtKB-AC P04983 http://www.uniprot.org/uniprot/P04983 charge swissprot:RBSA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RBSA_ECOLI eggNOG COG1129 http://eggnogapi.embl.de/nog_data/html/tree/COG1129 eggNOG ENOG4105C2J http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C2J epestfind swissprot:RBSA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RBSA_ECOLI garnier swissprot:RBSA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RBSA_ECOLI helixturnhelix swissprot:RBSA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RBSA_ECOLI hmoment swissprot:RBSA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RBSA_ECOLI iep swissprot:RBSA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RBSA_ECOLI inforesidue swissprot:RBSA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RBSA_ECOLI octanol swissprot:RBSA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RBSA_ECOLI pepcoil swissprot:RBSA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RBSA_ECOLI pepdigest swissprot:RBSA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RBSA_ECOLI pepinfo swissprot:RBSA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RBSA_ECOLI pepnet swissprot:RBSA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RBSA_ECOLI pepstats swissprot:RBSA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RBSA_ECOLI pepwheel swissprot:RBSA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RBSA_ECOLI pepwindow swissprot:RBSA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RBSA_ECOLI sigcleave swissprot:RBSA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RBSA_ECOLI ## Database ID URL or Descriptions # AltName ABDH_ECOLI 1-pyrroline dehydrogenase # AltName ABDH_ECOLI 4-aminobutanal dehydrogenase # BIOPHYSICOCHEMICAL PROPERTIES ABDH_ECOLI Kinetic parameters KM=41 uM for 4-aminobutanal {ECO 0000269|PubMed 16023116}; KM=196 uM for butanal {ECO 0000269|PubMed 16023116}; KM=54 uM for NAD(+) {ECO 0000269|PubMed 16023116}; KM=484 uM for NADP(+) {ECO 0000269|PubMed 16023116}; Vmax=9.08 umol/min/mg enzyme with 4-aminobutanal as substrate {ECO 0000269|PubMed 16023116}; Vmax=0.36 umol/min/mg enzyme with butanal as substrate {ECO 0000269|PubMed 16023116}; # BRENDA 1.2.1.19 2026 # BioGrid 4260192 6 # CATALYTIC ACTIVITY ABDH_ECOLI 4-aminobutanal + NAD(+) + H(2)O = 4- aminobutanoate + NADH. # CDD cd07092 ALDH_ABALDH-YdcW # EcoGene EG13766 prr # FUNCTION ABDH_ECOLI Catalyzes the oxidation of 1-pyrroline, which is spontaneously formed from 4-aminobutanal, leading to 4- aminobutanoate (GABA). Can also oxidize n-alkyl medium-chain aldehydes, but with a lower catalytic efficiency. {ECO 0000269|PubMed 15381418, ECO 0000269|PubMed 16023116}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0019145 aminobutyraldehyde dehydrogenase activity; IDA:EcoCyc. # GO_function GO:0033737 1-pyrroline dehydrogenase activity; IMP:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0051287 NAD binding; IEA:UniProtKB-HAMAP. # GO_process GO:0009447 putrescine catabolic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.309.10 -; 1. # Gene3D 3.40.605.10 -; 1. # HAMAP MF_01275 Aldedh_Prr # INDUCTION Up-regulated under nitrogen starvation conditions. {ECO:0000269|PubMed 16023116}. # IntAct P77674 4 # InterPro IPR015590 Aldehyde_DH_dom # InterPro IPR015657 Aminobutyraldehyde_DH # InterPro IPR016161 Ald_DH/histidinol_DH # InterPro IPR016162 Ald_DH_N # InterPro IPR016163 Ald_DH_C # InterPro IPR017749 1-pyrroline_dehydrogenase # InterPro IPR029510 Ald_DH_CS_GLU # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00330 Arginine and proline metabolism # KEGG_Pathway ko00410 beta-Alanine metabolism # MISCELLANEOUS ABDH_ECOLI 4-aminobutanal is also called gamma- aminobutyraldehyde. # Organism ABDH_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11699:SF109 PTHR11699:SF109 # PATHWAY Amine and polyamine degradation; putrescine degradation; 4-aminobutanoate from 4-aminobutanal step 1/1. # PATRIC 32118178 VBIEscCol129921_1509 # PDB 1WNB X-ray; 2.20 A; A/B/C/D=1-474 # PDB 1WND X-ray; 2.10 A; A/B/C/D=1-474 # PIR G64896 G64896 # PROSITE PS00687 ALDEHYDE_DEHYDR_GLU # Pfam PF00171 Aldedh # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ABDH_ECOLI Gamma-aminobutyraldehyde dehydrogenase # RefSeq NP_415961 NC_000913.3 # RefSeq WP_001163872 NZ_LN832404.1 # SIMILARITY Belongs to the aldehyde dehydrogenase family. Gamma- aminobutyraldehyde dehydrogenase subfamily. {ECO 0000305}. # SUBUNIT ABDH_ECOLI Homotetramer. {ECO 0000269|PubMed 15381418, ECO 0000269|PubMed 16023116}. # SUPFAM SSF53720 SSF53720 # TIGRFAMs TIGR03374 ABALDH # UniPathway UPA00188 UER00292 # eggNOG COG1012 LUCA # eggNOG ENOG4105C26 Bacteria BLAST swissprot:ABDH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ABDH_ECOLI BioCyc ECOL316407:JW1439-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1439-MONOMER BioCyc EcoCyc:G6755-MONOMER http://biocyc.org/getid?id=EcoCyc:G6755-MONOMER BioCyc MetaCyc:G6755-MONOMER http://biocyc.org/getid?id=MetaCyc:G6755-MONOMER COG COG1012 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1012 DIP DIP-11656N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11656N DOI 10.1016/j.febslet.2005.06.038 http://dx.doi.org/10.1016/j.febslet.2005.06.038 DOI 10.1016/j.jmb.2004.08.030 http://dx.doi.org/10.1016/j.jmb.2004.08.030 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.2.1.19 http://www.genome.jp/dbget-bin/www_bget?EC:1.2.1.19 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.2.1.19 http://enzyme.expasy.org/EC/1.2.1.19 EchoBASE EB3529 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3529 EcoGene EG13766 http://www.ecogene.org/geneInfo.php?eg_id=EG13766 EnsemblBacteria AAC74526 http://www.ensemblgenomes.org/id/AAC74526 EnsemblBacteria AAC74526 http://www.ensemblgenomes.org/id/AAC74526 EnsemblBacteria BAA15073 http://www.ensemblgenomes.org/id/BAA15073 EnsemblBacteria BAA15073 http://www.ensemblgenomes.org/id/BAA15073 EnsemblBacteria BAA15073 http://www.ensemblgenomes.org/id/BAA15073 EnsemblBacteria b1444 http://www.ensemblgenomes.org/id/b1444 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0019145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019145 GO_function GO:0033737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033737 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0051287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051287 GO_process GO:0009447 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009447 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.309.10 http://www.cathdb.info/version/latest/superfamily/3.40.309.10 Gene3D 3.40.605.10 http://www.cathdb.info/version/latest/superfamily/3.40.605.10 GeneID 945876 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945876 HAMAP MF_01275 http://hamap.expasy.org/unirule/MF_01275 HOGENOM HOG000271505 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000271505&db=HOGENOM6 InParanoid P77674 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77674 IntAct P77674 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77674* IntEnz 1.2.1.19 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.2.1.19 InterPro IPR015590 http://www.ebi.ac.uk/interpro/entry/IPR015590 InterPro IPR015657 http://www.ebi.ac.uk/interpro/entry/IPR015657 InterPro IPR016161 http://www.ebi.ac.uk/interpro/entry/IPR016161 InterPro IPR016162 http://www.ebi.ac.uk/interpro/entry/IPR016162 InterPro IPR016163 http://www.ebi.ac.uk/interpro/entry/IPR016163 InterPro IPR017749 http://www.ebi.ac.uk/interpro/entry/IPR017749 InterPro IPR029510 http://www.ebi.ac.uk/interpro/entry/IPR029510 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1439 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1439 KEGG_Gene eco:b1444 http://www.genome.jp/dbget-bin/www_bget?eco:b1444 KEGG_Orthology KO:K00137 http://www.genome.jp/dbget-bin/www_bget?KO:K00137 KEGG_Pathway ko00330 http://www.genome.jp/kegg-bin/show_pathway?ko00330 KEGG_Pathway ko00410 http://www.genome.jp/kegg-bin/show_pathway?ko00410 KEGG_Reaction rn:R02549 http://www.genome.jp/dbget-bin/www_bget?rn:R02549 OMA IRSFGFY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IRSFGFY PANTHER PTHR11699:SF109 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11699:SF109 PDB 1WNB http://www.ebi.ac.uk/pdbe-srv/view/entry/1WNB PDB 1WND http://www.ebi.ac.uk/pdbe-srv/view/entry/1WND PDBsum 1WNB http://www.ebi.ac.uk/pdbsum/1WNB PDBsum 1WND http://www.ebi.ac.uk/pdbsum/1WND PROSITE PS00687 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00687 PSORT swissprot:ABDH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ABDH_ECOLI PSORT-B swissprot:ABDH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ABDH_ECOLI PSORT2 swissprot:ABDH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ABDH_ECOLI Pfam PF00171 http://pfam.xfam.org/family/PF00171 Phobius swissprot:ABDH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ABDH_ECOLI PhylomeDB P77674 http://phylomedb.org/?seqid=P77674 ProteinModelPortal P77674 http://www.proteinmodelportal.org/query/uniprot/P77674 PubMed 15381418 http://www.ncbi.nlm.nih.gov/pubmed/15381418 PubMed 16023116 http://www.ncbi.nlm.nih.gov/pubmed/16023116 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415961 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415961 RefSeq WP_001163872 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001163872 SMR P77674 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77674 STRING 511145.b1444 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1444&targetmode=cogs STRING COG1012 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1012&targetmode=cogs SUPFAM SSF53720 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53720 TIGRFAMs TIGR03374 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03374 UniProtKB ABDH_ECOLI http://www.uniprot.org/uniprot/ABDH_ECOLI UniProtKB-AC P77674 http://www.uniprot.org/uniprot/P77674 charge swissprot:ABDH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ABDH_ECOLI eggNOG COG1012 http://eggnogapi.embl.de/nog_data/html/tree/COG1012 eggNOG ENOG4105C26 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C26 epestfind swissprot:ABDH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ABDH_ECOLI garnier swissprot:ABDH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ABDH_ECOLI helixturnhelix swissprot:ABDH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ABDH_ECOLI hmoment swissprot:ABDH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ABDH_ECOLI iep swissprot:ABDH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ABDH_ECOLI inforesidue swissprot:ABDH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ABDH_ECOLI octanol swissprot:ABDH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ABDH_ECOLI pepcoil swissprot:ABDH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ABDH_ECOLI pepdigest swissprot:ABDH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ABDH_ECOLI pepinfo swissprot:ABDH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ABDH_ECOLI pepnet swissprot:ABDH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ABDH_ECOLI pepstats swissprot:ABDH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ABDH_ECOLI pepwheel swissprot:ABDH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ABDH_ECOLI pepwindow swissprot:ABDH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ABDH_ECOLI sigcleave swissprot:ABDH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ABDH_ECOLI ## Database ID URL or Descriptions # BioGrid 4263223 14 # EcoGene EG13952 ydhR # FUNCTION YDHR_ECOLI May function as monooxygenase and play a role in the metabolism of aromatic compounds. {ECO 0000305}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0016491 oxidoreductase activity; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # INTERACTION YDHR_ECOLI P0A6Y8 dnaK; NbExp=2; IntAct=EBI-544817, EBI-542092; # IntAct P0ACX3 2 # InterPro IPR011008 Dimeric_a/b-barrel # InterPro IPR014910 YdhR # Organism YDHR_ECOLI Escherichia coli (strain K12) # PATRIC 32118640 VBIEscCol129921_1738 # PDB 1WD6 X-ray; 2.90 A; A/B=1-101 # PDB 2ASY NMR; -; A/B=1-101 # PDB 2HIQ X-ray; 2.00 A; A/B=2-101 # PIR C64924 C64924 # Pfam PF08803 ydhR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDHR_ECOLI Putative monooxygenase YdhR # RefSeq NP_416182 NC_000913.3 # RefSeq WP_000212657 NZ_LN832404.1 # SUBUNIT Homodimer. {ECO:0000269|PubMed 16260765}. # SUPFAM SSF54909 SSF54909 # eggNOG ENOG4105N0V Bacteria # eggNOG ENOG4111VBS LUCA BLAST swissprot:YDHR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDHR_ECOLI BioCyc ECOL316407:JW1657-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1657-MONOMER BioCyc EcoCyc:G6895-MONOMER http://biocyc.org/getid?id=EcoCyc:G6895-MONOMER DIP DIP-48270N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48270N DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1110/ps.051809305 http://dx.doi.org/10.1110/ps.051809305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U68703 http://www.ebi.ac.uk/ena/data/view/U68703 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- EchoBASE EB3710 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3710 EcoGene EG13952 http://www.ecogene.org/geneInfo.php?eg_id=EG13952 EnsemblBacteria AAC74737 http://www.ensemblgenomes.org/id/AAC74737 EnsemblBacteria AAC74737 http://www.ensemblgenomes.org/id/AAC74737 EnsemblBacteria BAE76495 http://www.ensemblgenomes.org/id/BAE76495 EnsemblBacteria BAE76495 http://www.ensemblgenomes.org/id/BAE76495 EnsemblBacteria BAE76495 http://www.ensemblgenomes.org/id/BAE76495 EnsemblBacteria b1667 http://www.ensemblgenomes.org/id/b1667 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GeneID 946177 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946177 HOGENOM HOG000270810 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000270810&db=HOGENOM6 InParanoid P0ACX3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACX3 IntAct P0ACX3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACX3* IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR011008 http://www.ebi.ac.uk/interpro/entry/IPR011008 InterPro IPR014910 http://www.ebi.ac.uk/interpro/entry/IPR014910 KEGG_Gene ecj:JW1657 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1657 KEGG_Gene eco:b1667 http://www.genome.jp/dbget-bin/www_bget?eco:b1667 OMA LWKIWTE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LWKIWTE PDB 1WD6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1WD6 PDB 2ASY http://www.ebi.ac.uk/pdbe-srv/view/entry/2ASY PDB 2HIQ http://www.ebi.ac.uk/pdbe-srv/view/entry/2HIQ PDBsum 1WD6 http://www.ebi.ac.uk/pdbsum/1WD6 PDBsum 2ASY http://www.ebi.ac.uk/pdbsum/2ASY PDBsum 2HIQ http://www.ebi.ac.uk/pdbsum/2HIQ PSORT swissprot:YDHR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDHR_ECOLI PSORT-B swissprot:YDHR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDHR_ECOLI PSORT2 swissprot:YDHR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDHR_ECOLI Pfam PF08803 http://pfam.xfam.org/family/PF08803 Phobius swissprot:YDHR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDHR_ECOLI ProteinModelPortal P0ACX3 http://www.proteinmodelportal.org/query/uniprot/P0ACX3 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 16260765 http://www.ncbi.nlm.nih.gov/pubmed/16260765 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9023191 http://www.ncbi.nlm.nih.gov/pubmed/9023191 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416182 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416182 RefSeq WP_000212657 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000212657 SMR P0ACX3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACX3 STRING 511145.b1667 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1667&targetmode=cogs SUPFAM SSF54909 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54909 UniProtKB YDHR_ECOLI http://www.uniprot.org/uniprot/YDHR_ECOLI UniProtKB-AC P0ACX3 http://www.uniprot.org/uniprot/P0ACX3 charge swissprot:YDHR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDHR_ECOLI eggNOG ENOG4105N0V http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105N0V eggNOG ENOG4111VBS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111VBS epestfind swissprot:YDHR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDHR_ECOLI garnier swissprot:YDHR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDHR_ECOLI helixturnhelix swissprot:YDHR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDHR_ECOLI hmoment swissprot:YDHR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDHR_ECOLI iep swissprot:YDHR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDHR_ECOLI inforesidue swissprot:YDHR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDHR_ECOLI octanol swissprot:YDHR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDHR_ECOLI pepcoil swissprot:YDHR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDHR_ECOLI pepdigest swissprot:YDHR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDHR_ECOLI pepinfo swissprot:YDHR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDHR_ECOLI pepnet swissprot:YDHR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDHR_ECOLI pepstats swissprot:YDHR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDHR_ECOLI pepwheel swissprot:YDHR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDHR_ECOLI pepwindow swissprot:YDHR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDHR_ECOLI sigcleave swissprot:YDHR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDHR_ECOLI ## Database ID URL or Descriptions # BioGrid 4262347 3 # EcoGene EG13164 yqgB # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_process GO:0010447 response to acidic pH; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_process GO:0008150 biological_process # INDUCTION YQGB_ECOLI Constitutively expressed; increases in exponential phase (PubMed 19121005), repressed by H(2)O(2) (PubMed 19121005) (at protein level). {ECO 0000269|PubMed 19121005, ECO 0000269|PubMed 19734316}. # InterPro IPR020196 Uncharacterised_YqgB # Organism YQGB_ECOLI Escherichia coli (strain K12) # PATRIC 32121290 VBIEscCol129921_3033 # PIR B65079 B65079 # Pfam PF11036 YqgB # ProDom PD050163 Uncharacterised_YqgB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQGB_ECOLI Uncharacterized protein YqgB # RefSeq NP_417414 NC_000913.3 # RefSeq WP_001297406 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA69106.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAE77002.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the YqgB family. {ECO 0000305}. # SUBCELLULAR LOCATION YQGB_ECOLI Cytoplasm {ECO 0000269|PubMed 19121005}. BLAST swissprot:YQGB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQGB_ECOLI BioCyc ECOL316407:JW2906-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2906-MONOMER BioCyc EcoCyc:G7521-MONOMER http://biocyc.org/getid?id=EcoCyc:G7521-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2008.06495.x http://dx.doi.org/10.1111/j.1365-2958.2008.06495.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00872-09 http://dx.doi.org/10.1128/JB.00872-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2956 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2956 EcoGene EG13164 http://www.ecogene.org/geneInfo.php?eg_id=EG13164 EnsemblBacteria AAC75976 http://www.ensemblgenomes.org/id/AAC75976 EnsemblBacteria AAC75976 http://www.ensemblgenomes.org/id/AAC75976 EnsemblBacteria BAE77002 http://www.ensemblgenomes.org/id/BAE77002 EnsemblBacteria BAE77002 http://www.ensemblgenomes.org/id/BAE77002 EnsemblBacteria BAE77002 http://www.ensemblgenomes.org/id/BAE77002 EnsemblBacteria b2939 http://www.ensemblgenomes.org/id/b2939 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_process GO:0010447 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010447 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 947433 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947433 HOGENOM HOG000009560 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009560&db=HOGENOM6 InterPro IPR020196 http://www.ebi.ac.uk/interpro/entry/IPR020196 KEGG_Gene ecj:JW2906 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2906 KEGG_Gene eco:b2939 http://www.genome.jp/dbget-bin/www_bget?eco:b2939 PSORT swissprot:YQGB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQGB_ECOLI PSORT-B swissprot:YQGB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQGB_ECOLI PSORT2 swissprot:YQGB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQGB_ECOLI Pfam PF11036 http://pfam.xfam.org/family/PF11036 Phobius swissprot:YQGB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQGB_ECOLI ProteinModelPortal P64567 http://www.proteinmodelportal.org/query/uniprot/P64567 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19121005 http://www.ncbi.nlm.nih.gov/pubmed/19121005 PubMed 19734316 http://www.ncbi.nlm.nih.gov/pubmed/19734316 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417414 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417414 RefSeq WP_001297406 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001297406 STRING 511145.b2939 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2939&targetmode=cogs UniProtKB YQGB_ECOLI http://www.uniprot.org/uniprot/YQGB_ECOLI UniProtKB-AC P64567 http://www.uniprot.org/uniprot/P64567 charge swissprot:YQGB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQGB_ECOLI epestfind swissprot:YQGB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQGB_ECOLI garnier swissprot:YQGB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQGB_ECOLI helixturnhelix swissprot:YQGB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQGB_ECOLI hmoment swissprot:YQGB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQGB_ECOLI iep swissprot:YQGB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQGB_ECOLI inforesidue swissprot:YQGB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQGB_ECOLI octanol swissprot:YQGB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQGB_ECOLI pepcoil swissprot:YQGB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQGB_ECOLI pepdigest swissprot:YQGB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQGB_ECOLI pepinfo swissprot:YQGB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQGB_ECOLI pepnet swissprot:YQGB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQGB_ECOLI pepstats swissprot:YQGB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQGB_ECOLI pepwheel swissprot:YQGB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQGB_ECOLI pepwindow swissprot:YQGB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQGB_ECOLI sigcleave swissprot:YQGB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQGB_ECOLI ## Database ID URL or Descriptions # AltName FDOI_ECOLI Aerobic formate dehydrogenase cytochrome b556 subunit # AltName FDOI_ECOLI FDH-Z subunit gamma # AltName FDOI_ECOLI Formate dehydrogenase-O subunit gamma # BioGrid 4262641 15 # COFACTOR FDOI_ECOLI Name=heme; Xref=ChEBI CHEBI 30413; Evidence={ECO 0000250}; Note=Binds 2 heme groups per subunit. Heme 1 is located at the cytoplasmic interface, heme 2 is located at the periplasmic interface. Electrons are transferred from the periplasmic to the cytoplasmic heme. {ECO 0000250}; # EcoGene EG11856 fdoI # FUNCTION FDOI_ECOLI Allows to use formate as major electron donor during aerobic respiration. Subunit gamma is probably the cytochrome b556(FDO) component of the formate dehydrogenase. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; ISM:EcoCyc. # GO_component GO:0009326 formate dehydrogenase complex; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IBA:GO_Central. # GO_function GO:0008863 formate dehydrogenase (NAD+) activity; IEA:InterPro. # GO_function GO:0009055 electron carrier activity; IEA:InterPro. # GO_function GO:0036397 formate dehydrogenase (quinone) activity; IBA:GO_Central. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0015944 formate oxidation; IDA:EcoCyc. # GO_process GO:0022904 respiratory electron transport chain; IEA:InterPro. # GO_process GO:0045333 cellular respiration; IEP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0006950 response to stress # GOslim_process GO:0044281 small molecule metabolic process # InterPro IPR006471 Formate_DH_gsu # InterPro IPR011577 Cyt_b561_bac/Ni-Hgenase # InterPro IPR016174 Di-haem_cyt_TM # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Pathway ko00630 Glyoxylate and dicarboxylate metabolism # KEGG_Pathway ko00680 Methane metabolism # Organism FDOI_ECOLI Escherichia coli (strain K12) # PATRIC 32123291 VBIEscCol129921_4006 # PIR S40836 S40836 # Pfam PF01292 Ni_hydr_CYTB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FDOI_ECOLI Formate dehydrogenase, cytochrome b556(fdo) subunit # RefSeq NP_418328 NC_000913.3 # RefSeq WP_000829013 NZ_LN832404.1 # SIMILARITY Belongs to the formate dehydrogenase gamma subunit family. {ECO 0000305}. # SUBCELLULAR LOCATION FDOI_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT FDOI_ECOLI Formate dehydrogenase is a membrane-bound complex, formed by subunits alpha, beta and gamma. # SUPFAM SSF81342 SSF81342 # TIGRFAMs TIGR01583 formate-DH-gamm # eggNOG COG2864 LUCA # eggNOG ENOG4108MG3 Bacteria BLAST swissprot:FDOI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FDOI_ECOLI BioCyc ECOL316407:JW3863-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3863-MONOMER BioCyc EcoCyc:FDOI-MONOMER http://biocyc.org/getid?id=EcoCyc:FDOI-MONOMER BioCyc MetaCyc:FDOI-MONOMER http://biocyc.org/getid?id=MetaCyc:FDOI-MONOMER COG COG2864 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2864 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1802 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1802 EcoGene EG11856 http://www.ecogene.org/geneInfo.php?eg_id=EG11856 EnsemblBacteria AAD13454 http://www.ensemblgenomes.org/id/AAD13454 EnsemblBacteria AAD13454 http://www.ensemblgenomes.org/id/AAD13454 EnsemblBacteria BAE77417 http://www.ensemblgenomes.org/id/BAE77417 EnsemblBacteria BAE77417 http://www.ensemblgenomes.org/id/BAE77417 EnsemblBacteria BAE77417 http://www.ensemblgenomes.org/id/BAE77417 EnsemblBacteria b3892 http://www.ensemblgenomes.org/id/b3892 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0009326 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009326 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008863 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008863 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0036397 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036397 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0015944 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015944 GO_process GO:0022904 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022904 GO_process GO:0045333 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045333 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 948383 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948383 HOGENOM HOG000163500 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000163500&db=HOGENOM6 InParanoid P0AEL0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEL0 IntAct P0AEL0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEL0* InterPro IPR006471 http://www.ebi.ac.uk/interpro/entry/IPR006471 InterPro IPR011577 http://www.ebi.ac.uk/interpro/entry/IPR011577 InterPro IPR016174 http://www.ebi.ac.uk/interpro/entry/IPR016174 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Gene ecj:JW3863 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3863 KEGG_Gene eco:b3892 http://www.genome.jp/dbget-bin/www_bget?eco:b3892 KEGG_Orthology KO:K00127 http://www.genome.jp/dbget-bin/www_bget?KO:K00127 KEGG_Pathway ko00630 http://www.genome.jp/kegg-bin/show_pathway?ko00630 KEGG_Pathway ko00680 http://www.genome.jp/kegg-bin/show_pathway?ko00680 KEGG_Reaction rn:R00519 http://www.genome.jp/dbget-bin/www_bget?rn:R00519 OMA AFCFVFA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AFCFVFA PSORT swissprot:FDOI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FDOI_ECOLI PSORT-B swissprot:FDOI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FDOI_ECOLI PSORT2 swissprot:FDOI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FDOI_ECOLI Pfam PF01292 http://pfam.xfam.org/family/PF01292 Phobius swissprot:FDOI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FDOI_ECOLI PhylomeDB P0AEL0 http://phylomedb.org/?seqid=P0AEL0 ProteinModelPortal P0AEL0 http://www.proteinmodelportal.org/query/uniprot/P0AEL0 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 8522521 http://www.ncbi.nlm.nih.gov/pubmed/8522521 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9852007 http://www.ncbi.nlm.nih.gov/pubmed/9852007 RefSeq NP_418328 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418328 RefSeq WP_000829013 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000829013 SMR P0AEL0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEL0 STRING 511145.b3892 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3892&targetmode=cogs STRING COG2864 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2864&targetmode=cogs SUPFAM SSF81342 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81342 TIGRFAMs TIGR01583 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01583 UniProtKB FDOI_ECOLI http://www.uniprot.org/uniprot/FDOI_ECOLI UniProtKB-AC P0AEL0 http://www.uniprot.org/uniprot/P0AEL0 charge swissprot:FDOI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FDOI_ECOLI eggNOG COG2864 http://eggnogapi.embl.de/nog_data/html/tree/COG2864 eggNOG ENOG4108MG3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MG3 epestfind swissprot:FDOI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FDOI_ECOLI garnier swissprot:FDOI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FDOI_ECOLI helixturnhelix swissprot:FDOI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FDOI_ECOLI hmoment swissprot:FDOI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FDOI_ECOLI iep swissprot:FDOI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FDOI_ECOLI inforesidue swissprot:FDOI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FDOI_ECOLI octanol swissprot:FDOI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FDOI_ECOLI pepcoil swissprot:FDOI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FDOI_ECOLI pepdigest swissprot:FDOI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FDOI_ECOLI pepinfo swissprot:FDOI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FDOI_ECOLI pepnet swissprot:FDOI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FDOI_ECOLI pepstats swissprot:FDOI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FDOI_ECOLI pepwheel swissprot:FDOI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FDOI_ECOLI pepwindow swissprot:FDOI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FDOI_ECOLI sigcleave swissprot:FDOI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FDOI_ECOLI ## Database ID URL or Descriptions # BioGrid 4261017 531 # EcoGene EG11558 caiC # FUNCTION CAIC_ECOLI Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle. # GO_function GO:0016878 acid-thiol ligase activity; IEA:InterPro. # GO_function GO:0051108 carnitine-CoA ligase activity; IDA:EcoCyc. # GO_function GO:0051109 crotonobetaine-CoA ligase activity; IDA:EcoCyc. # GO_process GO:0009437 carnitine metabolic process; IEA:UniProtKB-UniPathway. # GOslim_function GO:0016874 ligase activity # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # HAMAP MF_01524 CaiC # INTERACTION CAIC_ECOLI P0ACN4 allR; NbExp=3; IntAct=EBI-1112975, EBI-561736; # IntAct P31552 5 # InterPro IPR000873 AMP-dep_Synth/Lig # InterPro IPR020845 AMP-binding_CS # InterPro IPR023456 CaiC # InterPro IPR025110 AMP-bd_C # KEGG_Brite ko01000 Enzymes # Organism CAIC_ECOLI Escherichia coli (strain K12) # PATHWAY CAIC_ECOLI Amine and polyamine metabolism; carnitine metabolism. # PATRIC 32115169 VBIEscCol129921_0036 # PIR E64724 S40558 # PROSITE PS00455 AMP_BINDING # Pfam PF00501 AMP-binding # Pfam PF13193 AMP-binding_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CAIC_ECOLI Probable crotonobetaine/carnitine-CoA ligase # RefSeq NP_414579 NC_000913.3 # RefSeq WP_001350478 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAB96606.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA52113.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ATP-dependent AMP-binding enzyme family. {ECO 0000305}. # TCDB 4.C.1.1 the proposed fatty acid transporter (fat) family # eggNOG COG0318 LUCA # eggNOG ENOG4105CEY Bacteria BLAST swissprot:CAIC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CAIC_ECOLI BioCyc ECOL316407:JW0036-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0036-MONOMER BioCyc EcoCyc:CAIC-MONOMER http://biocyc.org/getid?id=EcoCyc:CAIC-MONOMER BioCyc MetaCyc:CAIC-MONOMER http://biocyc.org/getid?id=MetaCyc:CAIC-MONOMER COG COG0318 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0318 DIP DIP-9243N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9243N DOI 10.1007/s00239-002-2423-0 http://dx.doi.org/10.1007/s00239-002-2423-0 DOI 10.1016/S0014-5793(01)03178-7 http://dx.doi.org/10.1016/S0014-5793(01)03178-7 DOI 10.1021/bi048481c http://dx.doi.org/10.1021/bi048481c DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1111/j.1365-2958.1994.tb00470.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb00470.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.2.1.- http://www.genome.jp/dbget-bin/www_bget?EC:6.2.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL AY625099 http://www.ebi.ac.uk/ena/data/view/AY625099 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X73904 http://www.ebi.ac.uk/ena/data/view/X73904 ENZYME 6.2.1.- http://enzyme.expasy.org/EC/6.2.1.- EchoBASE EB1519 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1519 EcoGene EG11558 http://www.ecogene.org/geneInfo.php?eg_id=EG11558 EnsemblBacteria AAC73148 http://www.ensemblgenomes.org/id/AAC73148 EnsemblBacteria AAC73148 http://www.ensemblgenomes.org/id/AAC73148 EnsemblBacteria BAB96606 http://www.ensemblgenomes.org/id/BAB96606 EnsemblBacteria BAB96606 http://www.ensemblgenomes.org/id/BAB96606 EnsemblBacteria BAB96606 http://www.ensemblgenomes.org/id/BAB96606 EnsemblBacteria b0037 http://www.ensemblgenomes.org/id/b0037 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016878 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016878 GO_function GO:0051108 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051108 GO_function GO:0051109 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051109 GO_process GO:0009437 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009437 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 944886 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944886 HAMAP MF_01524 http://hamap.expasy.org/unirule/MF_01524 HOGENOM HOG000230001 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230001&db=HOGENOM6 InParanoid P31552 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31552 IntAct P31552 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31552* IntEnz 6.2.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.2.1 InterPro IPR000873 http://www.ebi.ac.uk/interpro/entry/IPR000873 InterPro IPR020845 http://www.ebi.ac.uk/interpro/entry/IPR020845 InterPro IPR023456 http://www.ebi.ac.uk/interpro/entry/IPR023456 InterPro IPR025110 http://www.ebi.ac.uk/interpro/entry/IPR025110 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0036 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0036 KEGG_Gene eco:b0037 http://www.genome.jp/dbget-bin/www_bget?eco:b0037 KEGG_Orthology KO:K02182 http://www.genome.jp/dbget-bin/www_bget?KO:K02182 OMA TALIYES http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TALIYES PROSITE PS00455 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00455 PSORT swissprot:CAIC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CAIC_ECOLI PSORT-B swissprot:CAIC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CAIC_ECOLI PSORT2 swissprot:CAIC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CAIC_ECOLI Pfam PF00501 http://pfam.xfam.org/family/PF00501 Pfam PF13193 http://pfam.xfam.org/family/PF13193 Phobius swissprot:CAIC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CAIC_ECOLI PhylomeDB P31552 http://phylomedb.org/?seqid=P31552 ProteinModelPortal P31552 http://www.proteinmodelportal.org/query/uniprot/P31552 PubMed 11749953 http://www.ncbi.nlm.nih.gov/pubmed/11749953 PubMed 12664169 http://www.ncbi.nlm.nih.gov/pubmed/12664169 PubMed 15518548 http://www.ncbi.nlm.nih.gov/pubmed/15518548 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7815937 http://www.ncbi.nlm.nih.gov/pubmed/7815937 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414579 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414579 RefSeq WP_001350478 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001350478 SMR P31552 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31552 STRING 511145.b0037 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0037&targetmode=cogs STRING COG0318 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0318&targetmode=cogs TCDB 4.C.1.1 http://www.tcdb.org/search/result.php?tc=4.C.1.1 UniProtKB CAIC_ECOLI http://www.uniprot.org/uniprot/CAIC_ECOLI UniProtKB-AC P31552 http://www.uniprot.org/uniprot/P31552 charge swissprot:CAIC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CAIC_ECOLI eggNOG COG0318 http://eggnogapi.embl.de/nog_data/html/tree/COG0318 eggNOG ENOG4105CEY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CEY epestfind swissprot:CAIC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CAIC_ECOLI garnier swissprot:CAIC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CAIC_ECOLI helixturnhelix swissprot:CAIC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CAIC_ECOLI hmoment swissprot:CAIC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CAIC_ECOLI iep swissprot:CAIC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CAIC_ECOLI inforesidue swissprot:CAIC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CAIC_ECOLI octanol swissprot:CAIC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CAIC_ECOLI pepcoil swissprot:CAIC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CAIC_ECOLI pepdigest swissprot:CAIC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CAIC_ECOLI pepinfo swissprot:CAIC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CAIC_ECOLI pepnet swissprot:CAIC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CAIC_ECOLI pepstats swissprot:CAIC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CAIC_ECOLI pepwheel swissprot:CAIC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CAIC_ECOLI pepwindow swissprot:CAIC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CAIC_ECOLI sigcleave swissprot:CAIC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CAIC_ECOLI ## Database ID URL or Descriptions # AltName ALDA_ECOLI Aldehyde dehydrogenase A # AltName ALDA_ECOLI Glycolaldehyde dehydrogenase # BRENDA 1.2.1.22 2026 # BioGrid 4260173 9 # CATALYTIC ACTIVITY ALDA_ECOLI (S)-lactaldehyde + NAD(+) + H(2)O = (S)- lactate + NADH. # CATALYTIC ACTIVITY ALDA_ECOLI Glycolaldehyde + NAD(+) + H(2)O = glycolate + NADH. # EcoGene EG10035 aldA # FUNCTION ALDA_ECOLI Acts on lactaldehyde as well as other aldehydes. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004777 succinate-semialdehyde dehydrogenase (NAD+) activity; ISS:EcoCyc. # GO_function GO:0008911 lactaldehyde dehydrogenase activity; IDA:EcoCyc. # GO_function GO:0050569 glycolaldehyde dehydrogenase activity; IDA:EcoCyc. # GO_process GO:0019301 rhamnose catabolic process; IMP:EcoCyc. # GO_process GO:0042355 L-fucose catabolic process; IEP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.309.10 -; 1. # Gene3D 3.40.605.10 -; 1. # INDUCTION ALDA_ECOLI By growth on fucose, rhamnose, arabinose and amino acids such as glutamate. # IntAct P25553 5 # InterPro IPR015590 Aldehyde_DH_dom # InterPro IPR016160 Ald_DH_CS_CYS # InterPro IPR016161 Ald_DH/histidinol_DH # InterPro IPR016162 Ald_DH_N # InterPro IPR016163 Ald_DH_C # InterPro IPR029510 Ald_DH_CS_GLU # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00620 Pyruvate metabolism # KEGG_Pathway ko00630 Glyoxylate and dicarboxylate metabolism # Organism ALDA_ECOLI Escherichia coli (strain K12) # PATRIC 32118116 VBIEscCol129921_1478 # PDB 2HG2 X-ray; 2.20 A; A=1-479 # PDB 2ILU X-ray; 2.70 A; A=1-479 # PDB 2IMP X-ray; 2.10 A; A=1-479 # PDB 2OPX X-ray; 2.53 A; A=1-479 # PIR A38165 A38165 # PROSITE PS00070 ALDEHYDE_DEHYDR_CYS # PROSITE PS00687 ALDEHYDE_DEHYDR_GLU # Pfam PF00171 Aldedh # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ALDA_ECOLI Lactaldehyde dehydrogenase # RefSeq NP_415933 NC_000913.3 # RefSeq WP_000115943 NZ_LN832404.1 # SIMILARITY Belongs to the aldehyde dehydrogenase family. {ECO 0000305}. # SUBUNIT ALDA_ECOLI Homotetramer. # SUPFAM SSF53720 SSF53720 # eggNOG COG1012 LUCA # eggNOG ENOG4105C26 Bacteria BLAST swissprot:ALDA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ALDA_ECOLI BioCyc ECOL316407:JW1412-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1412-MONOMER BioCyc EcoCyc:LACTALDDEHYDROG-MONOMER http://biocyc.org/getid?id=EcoCyc:LACTALDDEHYDROG-MONOMER BioCyc MetaCyc:LACTALDDEHYDROG-MONOMER http://biocyc.org/getid?id=MetaCyc:LACTALDDEHYDROG-MONOMER COG COG1012 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1012 DIP DIP-9081N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9081N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.2.1.21 http://www.genome.jp/dbget-bin/www_bget?EC:1.2.1.21 EC_number EC:1.2.1.22 http://www.genome.jp/dbget-bin/www_bget?EC:1.2.1.22 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M64541 http://www.ebi.ac.uk/ena/data/view/M64541 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.2.1.21 http://enzyme.expasy.org/EC/1.2.1.21 ENZYME 1.2.1.22 http://enzyme.expasy.org/EC/1.2.1.22 EchoBASE EB0034 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0034 EcoGene EG10035 http://www.ecogene.org/geneInfo.php?eg_id=EG10035 EnsemblBacteria AAC74497 http://www.ensemblgenomes.org/id/AAC74497 EnsemblBacteria AAC74497 http://www.ensemblgenomes.org/id/AAC74497 EnsemblBacteria BAA15032 http://www.ensemblgenomes.org/id/BAA15032 EnsemblBacteria BAA15032 http://www.ensemblgenomes.org/id/BAA15032 EnsemblBacteria BAA15032 http://www.ensemblgenomes.org/id/BAA15032 EnsemblBacteria b1415 http://www.ensemblgenomes.org/id/b1415 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004777 GO_function GO:0008911 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008911 GO_function GO:0050569 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050569 GO_process GO:0019301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019301 GO_process GO:0042355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042355 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.309.10 http://www.cathdb.info/version/latest/superfamily/3.40.309.10 Gene3D 3.40.605.10 http://www.cathdb.info/version/latest/superfamily/3.40.605.10 GeneID 945672 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945672 HOGENOM HOG000271509 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000271509&db=HOGENOM6 InParanoid P25553 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P25553 IntAct P25553 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P25553* IntEnz 1.2.1.21 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.2.1.21 IntEnz 1.2.1.22 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.2.1.22 InterPro IPR015590 http://www.ebi.ac.uk/interpro/entry/IPR015590 InterPro IPR016160 http://www.ebi.ac.uk/interpro/entry/IPR016160 InterPro IPR016161 http://www.ebi.ac.uk/interpro/entry/IPR016161 InterPro IPR016162 http://www.ebi.ac.uk/interpro/entry/IPR016162 InterPro IPR016163 http://www.ebi.ac.uk/interpro/entry/IPR016163 InterPro IPR029510 http://www.ebi.ac.uk/interpro/entry/IPR029510 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1412 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1412 KEGG_Gene eco:b1415 http://www.genome.jp/dbget-bin/www_bget?eco:b1415 KEGG_Orthology KO:K07248 http://www.genome.jp/dbget-bin/www_bget?KO:K07248 KEGG_Pathway ko00620 http://www.genome.jp/kegg-bin/show_pathway?ko00620 KEGG_Pathway ko00630 http://www.genome.jp/kegg-bin/show_pathway?ko00630 KEGG_Reaction rn:R00203 http://www.genome.jp/dbget-bin/www_bget?rn:R00203 KEGG_Reaction rn:R01333 http://www.genome.jp/dbget-bin/www_bget?rn:R01333 KEGG_Reaction rn:R01446 http://www.genome.jp/dbget-bin/www_bget?rn:R01446 MINT MINT-1313045 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1313045 OMA INEDHNA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=INEDHNA PDB 2HG2 http://www.ebi.ac.uk/pdbe-srv/view/entry/2HG2 PDB 2ILU http://www.ebi.ac.uk/pdbe-srv/view/entry/2ILU PDB 2IMP http://www.ebi.ac.uk/pdbe-srv/view/entry/2IMP PDB 2OPX http://www.ebi.ac.uk/pdbe-srv/view/entry/2OPX PDBsum 2HG2 http://www.ebi.ac.uk/pdbsum/2HG2 PDBsum 2ILU http://www.ebi.ac.uk/pdbsum/2ILU PDBsum 2IMP http://www.ebi.ac.uk/pdbsum/2IMP PDBsum 2OPX http://www.ebi.ac.uk/pdbsum/2OPX PROSITE PS00070 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00070 PROSITE PS00687 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00687 PSORT swissprot:ALDA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ALDA_ECOLI PSORT-B swissprot:ALDA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ALDA_ECOLI PSORT2 swissprot:ALDA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ALDA_ECOLI Pfam PF00171 http://pfam.xfam.org/family/PF00171 Phobius swissprot:ALDA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ALDA_ECOLI PhylomeDB P25553 http://phylomedb.org/?seqid=P25553 ProteinModelPortal P25553 http://www.proteinmodelportal.org/query/uniprot/P25553 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1917845 http://www.ncbi.nlm.nih.gov/pubmed/1917845 PubMed 3308886 http://www.ncbi.nlm.nih.gov/pubmed/3308886 PubMed 6345530 http://www.ncbi.nlm.nih.gov/pubmed/6345530 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_415933 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415933 RefSeq WP_000115943 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000115943 SMR P25553 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P25553 STRING 511145.b1415 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1415&targetmode=cogs STRING COG1012 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1012&targetmode=cogs SUPFAM SSF53720 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53720 SWISS-2DPAGE P25553 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P25553 UniProtKB ALDA_ECOLI http://www.uniprot.org/uniprot/ALDA_ECOLI UniProtKB-AC P25553 http://www.uniprot.org/uniprot/P25553 charge swissprot:ALDA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ALDA_ECOLI eggNOG COG1012 http://eggnogapi.embl.de/nog_data/html/tree/COG1012 eggNOG ENOG4105C26 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C26 epestfind swissprot:ALDA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ALDA_ECOLI garnier swissprot:ALDA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ALDA_ECOLI helixturnhelix swissprot:ALDA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ALDA_ECOLI hmoment swissprot:ALDA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ALDA_ECOLI iep swissprot:ALDA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ALDA_ECOLI inforesidue swissprot:ALDA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ALDA_ECOLI octanol swissprot:ALDA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ALDA_ECOLI pepcoil swissprot:ALDA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ALDA_ECOLI pepdigest swissprot:ALDA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ALDA_ECOLI pepinfo swissprot:ALDA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ALDA_ECOLI pepnet swissprot:ALDA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ALDA_ECOLI pepstats swissprot:ALDA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ALDA_ECOLI pepwheel swissprot:ALDA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ALDA_ECOLI pepwindow swissprot:ALDA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ALDA_ECOLI sigcleave swissprot:ALDA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ALDA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259177 87 # EcoGene EG12017 yohD # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0043093 FtsZ-dependent cytokinesis; IGI:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0008150 biological_process # InterPro IPR032816 SNARE_assoc # InterPro IPR032818 DedA # Organism YOHD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30353 PTHR30353 # PATRIC 32119615 VBIEscCol129921_2218 # PIR G64981 G64981 # Pfam PF09335 SNARE_assoc # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YOHD_ECOLI Inner membrane protein YohD # RefSeq NP_416640 NC_000913.3 # RefSeq WP_001296821 NZ_LN832404.1 # SIMILARITY Belongs to the DedA family. {ECO 0000305}. # SUBCELLULAR LOCATION YOHD_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG COG0586 LUCA # eggNOG ENOG4105KHU Bacteria BLAST swissprot:YOHD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YOHD_ECOLI BioCyc ECOL316407:JW2124-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2124-MONOMER BioCyc EcoCyc:EG12017-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12017-MONOMER DIP DIP-12805N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12805N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1954 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1954 EcoGene EG12017 http://www.ecogene.org/geneInfo.php?eg_id=EG12017 EnsemblBacteria AAC75197 http://www.ensemblgenomes.org/id/AAC75197 EnsemblBacteria AAC75197 http://www.ensemblgenomes.org/id/AAC75197 EnsemblBacteria BAE76613 http://www.ensemblgenomes.org/id/BAE76613 EnsemblBacteria BAE76613 http://www.ensemblgenomes.org/id/BAE76613 EnsemblBacteria BAE76613 http://www.ensemblgenomes.org/id/BAE76613 EnsemblBacteria b2136 http://www.ensemblgenomes.org/id/b2136 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0043093 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043093 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 946661 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946661 HOGENOM HOG000105365 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000105365&db=HOGENOM6 InParanoid P33366 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33366 IntAct P33366 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33366* InterPro IPR032816 http://www.ebi.ac.uk/interpro/entry/IPR032816 InterPro IPR032818 http://www.ebi.ac.uk/interpro/entry/IPR032818 KEGG_Gene ecj:JW2124 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2124 KEGG_Gene eco:b2136 http://www.genome.jp/dbget-bin/www_bget?eco:b2136 MINT MINT-1269234 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1269234 OMA RMRESKV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RMRESKV PANTHER PTHR30353 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30353 PSORT swissprot:YOHD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YOHD_ECOLI PSORT-B swissprot:YOHD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YOHD_ECOLI PSORT2 swissprot:YOHD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YOHD_ECOLI Pfam PF09335 http://pfam.xfam.org/family/PF09335 Phobius swissprot:YOHD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YOHD_ECOLI PhylomeDB P33366 http://phylomedb.org/?seqid=P33366 ProteinModelPortal P33366 http://www.proteinmodelportal.org/query/uniprot/P33366 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416640 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416640 RefSeq WP_001296821 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001296821 STRING 511145.b2136 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2136&targetmode=cogs UniProtKB YOHD_ECOLI http://www.uniprot.org/uniprot/YOHD_ECOLI UniProtKB-AC P33366 http://www.uniprot.org/uniprot/P33366 charge swissprot:YOHD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YOHD_ECOLI eggNOG COG0586 http://eggnogapi.embl.de/nog_data/html/tree/COG0586 eggNOG ENOG4105KHU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KHU epestfind swissprot:YOHD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YOHD_ECOLI garnier swissprot:YOHD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YOHD_ECOLI helixturnhelix swissprot:YOHD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YOHD_ECOLI hmoment swissprot:YOHD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YOHD_ECOLI iep swissprot:YOHD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YOHD_ECOLI inforesidue swissprot:YOHD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YOHD_ECOLI octanol swissprot:YOHD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YOHD_ECOLI pepcoil swissprot:YOHD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YOHD_ECOLI pepdigest swissprot:YOHD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YOHD_ECOLI pepinfo swissprot:YOHD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YOHD_ECOLI pepnet swissprot:YOHD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YOHD_ECOLI pepstats swissprot:YOHD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YOHD_ECOLI pepwheel swissprot:YOHD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YOHD_ECOLI pepwindow swissprot:YOHD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YOHD_ECOLI sigcleave swissprot:YOHD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YOHD_ECOLI ## Database ID URL or Descriptions # BRENDA 1.1.1.159 2026 # BioGrid 4259598 16 # CATALYTIC ACTIVITY HDHA_ECOLI 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta- cholanate + NAD(+) = 3-alpha,12-alpha-dihydroxy-7-oxo-5-beta- cholanate + NADH. # EcoGene EG10425 hdhA # FUNCTION HDHA_ECOLI 7-alpha-dehydroxylation of cholic acid, yielding deoxycholic acid and lithocholic acid, respectively. Highest affinity with taurochenodeoxycholic acid. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0008709 cholate 7-alpha-dehydrogenase activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0030573 bile acid catabolic process; IDA:EcoCyc. # GO_process GO:0051289 protein homotetramerization; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.720 -; 1. # IntAct P0AET8 5 # InterPro IPR002347 SDR_fam # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR020904 Sc_DH/Rdtase_CS # KEGG_Brite ko01000 Enzymes # Organism HDHA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR24322 PTHR24322; 2 # PATRIC 32118540 VBIEscCol129921_1690 # PDB 1AHH X-ray; 2.30 A; A/B=1-255 # PDB 1AHI X-ray; 2.30 A; A/B=1-255 # PDB 1FMC X-ray; 1.80 A; A/B=1-255 # PIR A38527 A38527 # PRINTS PR00080 SDRFAMILY # PRINTS PR00081 GDHRDH # PROSITE PS00061 ADH_SHORT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HDHA_ECOLI 7-alpha-hydroxysteroid dehydrogenase # RefSeq NP_416136 NC_000913.3 # RefSeq WP_000483353 NZ_LN832404.1 # SIMILARITY Belongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO 0000305}. # SUBUNIT Homotetramer. {ECO:0000269|PubMed 8672472}. # SUPFAM SSF51735 SSF51735 # eggNOG ENOG4107ZQV Bacteria # eggNOG ENOG410XPR5 LUCA BLAST swissprot:HDHA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HDHA_ECOLI BioCyc ECOL316407:JW1611-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1611-MONOMER BioCyc EcoCyc:7-ALPHA-HYDROXYSTEROID-DEH-MONOMER http://biocyc.org/getid?id=EcoCyc:7-ALPHA-HYDROXYSTEROID-DEH-MONOMER BioCyc MetaCyc:7-ALPHA-HYDROXYSTEROID-DEH-MONOMER http://biocyc.org/getid?id=MetaCyc:7-ALPHA-HYDROXYSTEROID-DEH-MONOMER COG COG1028 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1028 DIP DIP-9875N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9875N DOI 10.1021/bi951904d http://dx.doi.org/10.1021/bi951904d DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/oxfordjournals.jbchem.a022159 http://dx.doi.org/10.1093/oxfordjournals.jbchem.a022159 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.159 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.159 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D10497 http://www.ebi.ac.uk/ena/data/view/D10497 EMBL M14641 http://www.ebi.ac.uk/ena/data/view/M14641 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.1.1.159 http://enzyme.expasy.org/EC/1.1.1.159 EchoBASE EB0420 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0420 EcoGene EG10425 http://www.ecogene.org/geneInfo.php?eg_id=EG10425 EnsemblBacteria AAC74691 http://www.ensemblgenomes.org/id/AAC74691 EnsemblBacteria AAC74691 http://www.ensemblgenomes.org/id/AAC74691 EnsemblBacteria BAA15370 http://www.ensemblgenomes.org/id/BAA15370 EnsemblBacteria BAA15370 http://www.ensemblgenomes.org/id/BAA15370 EnsemblBacteria BAA15370 http://www.ensemblgenomes.org/id/BAA15370 EnsemblBacteria b1619 http://www.ensemblgenomes.org/id/b1619 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008709 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008709 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0030573 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030573 GO_process GO:0051289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051289 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 946151 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946151 InParanoid P0AET8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AET8 IntAct P0AET8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AET8* IntEnz 1.1.1.159 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.159 InterPro IPR002347 http://www.ebi.ac.uk/interpro/entry/IPR002347 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR020904 http://www.ebi.ac.uk/interpro/entry/IPR020904 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ag:BAA01384 http://www.genome.jp/dbget-bin/www_bget?ag:BAA01384 KEGG_Gene ecj:JW1611 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1611 KEGG_Gene eco:b1619 http://www.genome.jp/dbget-bin/www_bget?eco:b1619 KEGG_Orthology KO:K00076 http://www.genome.jp/dbget-bin/www_bget?KO:K00076 OMA THDWWNA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=THDWWNA PANTHER PTHR24322 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24322 PDB 1AHH http://www.ebi.ac.uk/pdbe-srv/view/entry/1AHH PDB 1AHI http://www.ebi.ac.uk/pdbe-srv/view/entry/1AHI PDB 1FMC http://www.ebi.ac.uk/pdbe-srv/view/entry/1FMC PDBsum 1AHH http://www.ebi.ac.uk/pdbsum/1AHH PDBsum 1AHI http://www.ebi.ac.uk/pdbsum/1AHI PDBsum 1FMC http://www.ebi.ac.uk/pdbsum/1FMC PRINTS PR00080 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00080 PRINTS PR00081 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00081 PROSITE PS00061 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00061 PSORT swissprot:HDHA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HDHA_ECOLI PSORT-B swissprot:HDHA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HDHA_ECOLI PSORT2 swissprot:HDHA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HDHA_ECOLI Phobius swissprot:HDHA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HDHA_ECOLI PhylomeDB P0AET8 http://phylomedb.org/?seqid=P0AET8 ProteinModelPortal P0AET8 http://www.proteinmodelportal.org/query/uniprot/P0AET8 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2007545 http://www.ncbi.nlm.nih.gov/pubmed/2007545 PubMed 8672472 http://www.ncbi.nlm.nih.gov/pubmed/8672472 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9722677 http://www.ncbi.nlm.nih.gov/pubmed/9722677 RefSeq NP_416136 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416136 RefSeq WP_000483353 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000483353 SMR P0AET8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AET8 STRING 511145.b1619 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1619&targetmode=cogs STRING COG1028 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1028&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 SWISS-2DPAGE P0AET8 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AET8 UniProtKB HDHA_ECOLI http://www.uniprot.org/uniprot/HDHA_ECOLI UniProtKB-AC P0AET8 http://www.uniprot.org/uniprot/P0AET8 charge swissprot:HDHA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HDHA_ECOLI eggNOG ENOG4107ZQV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107ZQV eggNOG ENOG410XPR5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPR5 epestfind swissprot:HDHA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HDHA_ECOLI garnier swissprot:HDHA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HDHA_ECOLI helixturnhelix swissprot:HDHA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HDHA_ECOLI hmoment swissprot:HDHA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HDHA_ECOLI iep swissprot:HDHA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HDHA_ECOLI inforesidue swissprot:HDHA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HDHA_ECOLI octanol swissprot:HDHA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HDHA_ECOLI pepcoil swissprot:HDHA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HDHA_ECOLI pepdigest swissprot:HDHA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HDHA_ECOLI pepinfo swissprot:HDHA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HDHA_ECOLI pepnet swissprot:HDHA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HDHA_ECOLI pepstats swissprot:HDHA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HDHA_ECOLI pepwheel swissprot:HDHA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HDHA_ECOLI pepwindow swissprot:HDHA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HDHA_ECOLI sigcleave swissprot:HDHA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HDHA_ECOLI ## Database ID URL or Descriptions # BRENDA 4.1.2.20 2026 # BioGrid 4261826 7 # EcoGene EG13344 yagE # FUNCTION YAGE_ECOLI Catalyzes the formation of 2-keto-3-deoxy-galactonate (KDGal) from pyruvate and glyceraldehyde. Overexpression leads to increased growth (over 2 hours) in the presence of the antibiotics norfloxacin, ampicillin and streptomycin. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0016829 lyase activity; IEA:UniProtKB-KW. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0046176 aldonic acid catabolic process; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.70 -; 1. # IntAct P75682 3 # InterPro IPR002220 DapA-like # InterPro IPR013785 Aldolase_TIM # InterPro IPR020624 Schiff_base-form_aldolases_CS # InterPro IPR020625 Schiff_base-form_aldolases_AS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00300 Lysine biosynthesis # MISCELLANEOUS YAGE_ECOLI Part of prophage CP4-6. # Organism YAGE_ECOLI Escherichia coli (strain K12) # PANTHER PTHR12128 PTHR12128 # PATRIC 32115657 VBIEscCol129921_0272 # PDB 2V8Z X-ray; 2.20 A; A/B/C/D=1-302 # PDB 2V9D X-ray; 2.15 A; A/B/C/D=1-302 # PDB 3N2X X-ray; 2.20 A; A/B/C/D=5-302 # PDB 3NEV X-ray; 2.19 A; A/B/C/D=5-302 # PDB 4OE7 X-ray; 1.99 A; A/B/C/D=1-302 # PDB 4ONV X-ray; 2.57 A; A/B/C/D=1-302 # PDB 4PTN X-ray; 1.99 A; A/B/C/D=1-302 # PDB 4U4M X-ray; 3.09 A; A/B/C/D=5-302 # PIR D64752 D64752 # PIRSF PIRSF001365 DHDPS # PRINTS PR00146 DHPICSNTHASE # PROSITE PS00665 DHDPS_1 # PROSITE PS00666 DHDPS_2 # Pfam PF00701 DHDPS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAGE_ECOLI Probable 2-keto-3-deoxy-galactonate aldolase YagE # RefSeq NP_414802 NC_000913.3 # RefSeq WP_001136613 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA77934.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the DapA family. {ECO 0000305}. # SMART SM01130 DHDPS # SUBCELLULAR LOCATION YAGE_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT YAGE_ECOLI A dimer of dimers. {ECO 0000269|PubMed 18361457, ECO 0000269|PubMed 21294156}. # eggNOG COG0329 LUCA # eggNOG ENOG4105CDP Bacteria BLAST swissprot:YAGE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAGE_ECOLI BioCyc ECOL316407:JW0261-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0261-MONOMER BioCyc EcoCyc:G6140-MONOMER http://biocyc.org/getid?id=EcoCyc:G6140-MONOMER BioCyc MetaCyc:G6140-MONOMER http://biocyc.org/getid?id=MetaCyc:G6140-MONOMER COG COG0329 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0329 DIP DIP-11232N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11232N DOI 10.1002/prot.22023 http://dx.doi.org/10.1002/prot.22023 DOI 10.1002/prot.22949 http://dx.doi.org/10.1002/prot.22949 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.1.2.- http://www.genome.jp/dbget-bin/www_bget?EC:4.1.2.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 4.1.2.- http://enzyme.expasy.org/EC/4.1.2.- EchoBASE EB3128 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3128 EcoGene EG13344 http://www.ecogene.org/geneInfo.php?eg_id=EG13344 EnsemblBacteria AAC73371 http://www.ensemblgenomes.org/id/AAC73371 EnsemblBacteria AAC73371 http://www.ensemblgenomes.org/id/AAC73371 EnsemblBacteria BAA77934 http://www.ensemblgenomes.org/id/BAA77934 EnsemblBacteria BAA77934 http://www.ensemblgenomes.org/id/BAA77934 EnsemblBacteria BAA77934 http://www.ensemblgenomes.org/id/BAA77934 EnsemblBacteria b0268 http://www.ensemblgenomes.org/id/b0268 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0046176 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046176 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 944925 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944925 HOGENOM HOG000173604 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000173604&db=HOGENOM6 InParanoid P75682 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75682 IntAct P75682 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75682* IntEnz 4.1.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.2 InterPro IPR002220 http://www.ebi.ac.uk/interpro/entry/IPR002220 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR020624 http://www.ebi.ac.uk/interpro/entry/IPR020624 InterPro IPR020625 http://www.ebi.ac.uk/interpro/entry/IPR020625 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0261 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0261 KEGG_Gene eco:b0268 http://www.genome.jp/dbget-bin/www_bget?eco:b0268 KEGG_Orthology KO:K01714 http://www.genome.jp/dbget-bin/www_bget?KO:K01714 KEGG_Pathway ko00300 http://www.genome.jp/kegg-bin/show_pathway?ko00300 KEGG_Reaction rn:R10147 http://www.genome.jp/dbget-bin/www_bget?rn:R10147 PANTHER PTHR12128 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12128 PDB 2V8Z http://www.ebi.ac.uk/pdbe-srv/view/entry/2V8Z PDB 2V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/2V9D PDB 3N2X http://www.ebi.ac.uk/pdbe-srv/view/entry/3N2X PDB 3NEV http://www.ebi.ac.uk/pdbe-srv/view/entry/3NEV PDB 4OE7 http://www.ebi.ac.uk/pdbe-srv/view/entry/4OE7 PDB 4ONV http://www.ebi.ac.uk/pdbe-srv/view/entry/4ONV PDB 4PTN http://www.ebi.ac.uk/pdbe-srv/view/entry/4PTN PDB 4U4M http://www.ebi.ac.uk/pdbe-srv/view/entry/4U4M PDBsum 2V8Z http://www.ebi.ac.uk/pdbsum/2V8Z PDBsum 2V9D http://www.ebi.ac.uk/pdbsum/2V9D PDBsum 3N2X http://www.ebi.ac.uk/pdbsum/3N2X PDBsum 3NEV http://www.ebi.ac.uk/pdbsum/3NEV PDBsum 4OE7 http://www.ebi.ac.uk/pdbsum/4OE7 PDBsum 4ONV http://www.ebi.ac.uk/pdbsum/4ONV PDBsum 4PTN http://www.ebi.ac.uk/pdbsum/4PTN PDBsum 4U4M http://www.ebi.ac.uk/pdbsum/4U4M PRINTS PR00146 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00146 PROSITE PS00665 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00665 PROSITE PS00666 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00666 PSORT swissprot:YAGE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAGE_ECOLI PSORT-B swissprot:YAGE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAGE_ECOLI PSORT2 swissprot:YAGE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAGE_ECOLI Pfam PF00701 http://pfam.xfam.org/family/PF00701 Phobius swissprot:YAGE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAGE_ECOLI ProteinModelPortal P75682 http://www.proteinmodelportal.org/query/uniprot/P75682 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18361457 http://www.ncbi.nlm.nih.gov/pubmed/18361457 PubMed 21294156 http://www.ncbi.nlm.nih.gov/pubmed/21294156 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414802 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414802 RefSeq WP_001136613 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001136613 SMART SM01130 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01130 SMR P75682 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75682 STRING 511145.b0268 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0268&targetmode=cogs STRING COG0329 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0329&targetmode=cogs UniProtKB YAGE_ECOLI http://www.uniprot.org/uniprot/YAGE_ECOLI UniProtKB-AC P75682 http://www.uniprot.org/uniprot/P75682 charge swissprot:YAGE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAGE_ECOLI eggNOG COG0329 http://eggnogapi.embl.de/nog_data/html/tree/COG0329 eggNOG ENOG4105CDP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CDP epestfind swissprot:YAGE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAGE_ECOLI garnier swissprot:YAGE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAGE_ECOLI helixturnhelix swissprot:YAGE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAGE_ECOLI hmoment swissprot:YAGE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAGE_ECOLI iep swissprot:YAGE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAGE_ECOLI inforesidue swissprot:YAGE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAGE_ECOLI octanol swissprot:YAGE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAGE_ECOLI pepcoil swissprot:YAGE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAGE_ECOLI pepdigest swissprot:YAGE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAGE_ECOLI pepinfo swissprot:YAGE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAGE_ECOLI pepnet swissprot:YAGE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAGE_ECOLI pepstats swissprot:YAGE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAGE_ECOLI pepwheel swissprot:YAGE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAGE_ECOLI pepwindow swissprot:YAGE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAGE_ECOLI sigcleave swissprot:YAGE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAGE_ECOLI ## Database ID URL or Descriptions # BioGrid 4261883 155 # CAUTION It is uncertain whether Met-1 or Met-20 is the initiator. {ECO 0000305}. # DISRUPTION PHENOTYPE FABR_ECOLI Significantly increased levels of unsaturated fatty acids (UFA) (PubMed 11859088, PubMed 19854834). Double fadR-fabR deletions have increased levels of saturated fatty acids, suggesting a functional fadR gene is required for fabR function (PubMed 11859088). Increased transcription of fabA and fabB (PubMed 11859088, PubMed 21276098). {ECO 0000269|PubMed 11859088, ECO 0000269|PubMed 19854834, ECO 0000269|PubMed 21276098}. # ENZYME REGULATION FABR_ECOLI Has been suggested to require either an unsaturated acyl carrier protein or unsaturated acyl-CoA (but not their saturated equivalents) for DNA-binding (PubMed 19854834). Another group suggests that unsaturated thioesters are not essential but act instead to enhance DNA-binding (PubMed 21276098). {ECO 0000269|PubMed 19854834, ECO 0000269|PubMed 21276098}. # EcoGene EG11394 fabR # FUNCTION FABR_ECOLI Binds the promoter region of at least fabA and fabB, but probably not yqfA (PubMed 11160901, PubMed 19854834, PubMed 21276098). Represses the transcription of fabA and fabB, involved in unsaturated fatty acid (UFA) biosynthesis (PubMed 11859088). By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer. {ECO 0000269|PubMed 11160901, ECO 0000269|PubMed 11859088, ECO 0000269|PubMed 19854834, ECO 0000269|PubMed 21276098}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0000976 transcription regulatory region sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006633 fatty acid biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0045717 negative regulation of fatty acid biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.357.10 -; 1. # HAMAP MF_01190 HTH_type_FabR # InterPro IPR001647 HTH_TetR # InterPro IPR009057 Homeodomain-like # InterPro IPR015893 Tet_transcr_reg_TetR-like_C # InterPro IPR023764 Tscrpt_reg_HTH_FabR # MISCELLANEOUS Probably part of the fabR-yijD operon. {ECO:0000305|PubMed 19854834}. # Organism FABR_ECOLI Escherichia coli (strain K12) # PATRIC 32123447 VBIEscCol129921_4084 # PROSITE PS50977 HTH_TETR_2 # Pfam PF00440 TetR_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HTH-type transcriptional repressor FabR {ECO:0000303|PubMed 11160901} # RefSeq NP_418398 NC_000913.3 # SEQUENCE CAUTION Sequence=AAC76945.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Contains 1 HTH tetR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00335}. # SUBCELLULAR LOCATION FABR_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT FABR_ECOLI Homodimer. {ECO 0000305|PubMed 19854834, ECO 0000305|PubMed 21276098}. # SUPFAM SSF46689 SSF46689 # eggNOG COG1309 LUCA # eggNOG ENOG4105EJ2 Bacteria BLAST swissprot:FABR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FABR_ECOLI BioCyc ECOL316407:JW3935-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3935-MONOMER BioCyc EcoCyc:EG11394-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11394-MONOMER DIP DIP-12520N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12520N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M109.068239 http://dx.doi.org/10.1074/jbc.M109.068239 DOI 10.1074/jbc.M201399200 http://dx.doi.org/10.1074/jbc.M201399200 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1093/nar/29.3.774 http://dx.doi.org/10.1093/nar/29.3.774 DOI 10.1111/j.1365-2958.2011.07564.x http://dx.doi.org/10.1111/j.1365-2958.2011.07564.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X66026 http://www.ebi.ac.uk/ena/data/view/X66026 EchoBASE EB1367 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1367 EcoGene EG11394 http://www.ecogene.org/geneInfo.php?eg_id=EG11394 EnsemblBacteria AAC76945 http://www.ensemblgenomes.org/id/AAC76945 EnsemblBacteria AAC76945 http://www.ensemblgenomes.org/id/AAC76945 EnsemblBacteria BAE77348 http://www.ensemblgenomes.org/id/BAE77348 EnsemblBacteria BAE77348 http://www.ensemblgenomes.org/id/BAE77348 EnsemblBacteria BAE77348 http://www.ensemblgenomes.org/id/BAE77348 EnsemblBacteria b3963 http://www.ensemblgenomes.org/id/b3963 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000976 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000976 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006633 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006633 GO_process GO:0045717 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045717 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.357.10 http://www.cathdb.info/version/latest/superfamily/1.10.357.10 GeneID 948460 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948460 HAMAP MF_01190 http://hamap.expasy.org/unirule/MF_01190 HOGENOM HOG000270364 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000270364&db=HOGENOM6 InParanoid P0ACU5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACU5 InterPro IPR001647 http://www.ebi.ac.uk/interpro/entry/IPR001647 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR015893 http://www.ebi.ac.uk/interpro/entry/IPR015893 InterPro IPR023764 http://www.ebi.ac.uk/interpro/entry/IPR023764 KEGG_Gene ecj:JW3935 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3935 KEGG_Gene eco:b3963 http://www.genome.jp/dbget-bin/www_bget?eco:b3963 OMA AYWYRKE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AYWYRKE PROSITE PS50977 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50977 PSORT swissprot:FABR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FABR_ECOLI PSORT-B swissprot:FABR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FABR_ECOLI PSORT2 swissprot:FABR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FABR_ECOLI Pfam PF00440 http://pfam.xfam.org/family/PF00440 Phobius swissprot:FABR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FABR_ECOLI PhylomeDB P0ACU5 http://phylomedb.org/?seqid=P0ACU5 ProteinModelPortal P0ACU5 http://www.proteinmodelportal.org/query/uniprot/P0ACU5 PubMed 11160901 http://www.ncbi.nlm.nih.gov/pubmed/11160901 PubMed 11859088 http://www.ncbi.nlm.nih.gov/pubmed/11859088 PubMed 1447162 http://www.ncbi.nlm.nih.gov/pubmed/1447162 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19854834 http://www.ncbi.nlm.nih.gov/pubmed/19854834 PubMed 21276098 http://www.ncbi.nlm.nih.gov/pubmed/21276098 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418398 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418398 SMR P0ACU5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACU5 STRING 511145.b3963 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3963&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 UniProtKB FABR_ECOLI http://www.uniprot.org/uniprot/FABR_ECOLI UniProtKB-AC P0ACU5 http://www.uniprot.org/uniprot/P0ACU5 charge swissprot:FABR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FABR_ECOLI eggNOG COG1309 http://eggnogapi.embl.de/nog_data/html/tree/COG1309 eggNOG ENOG4105EJ2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EJ2 epestfind swissprot:FABR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FABR_ECOLI garnier swissprot:FABR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FABR_ECOLI helixturnhelix swissprot:FABR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FABR_ECOLI hmoment swissprot:FABR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FABR_ECOLI iep swissprot:FABR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FABR_ECOLI inforesidue swissprot:FABR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FABR_ECOLI octanol swissprot:FABR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FABR_ECOLI pepcoil swissprot:FABR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FABR_ECOLI pepdigest swissprot:FABR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FABR_ECOLI pepinfo swissprot:FABR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FABR_ECOLI pepnet swissprot:FABR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FABR_ECOLI pepstats swissprot:FABR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FABR_ECOLI pepwheel swissprot:FABR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FABR_ECOLI pepwindow swissprot:FABR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FABR_ECOLI sigcleave swissprot:FABR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FABR_ECOLI ## Database ID URL or Descriptions # BRENDA 3.1.26 2026 # BioGrid 4261585 83 # CATALYTIC ACTIVITY RNH2_ECOLI Endonucleolytic cleavage to 5'- phosphomonoester. # CDD cd07182 RNase_HII_bacteria_HII_like # COFACTOR RNH2_ECOLI Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000250}; Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250}; Note=Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. {ECO 0000250}; # EcoGene EG10861 rnhB # FUNCTION RNH2_ECOLI Endonuclease that specifically degrades the RNA of RNA- DNA hybrids. {ECO 0000250, ECO 0000269|PubMed 2172991}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_component GO:0032299 ribonuclease H2 complex; IBA:GO_Central. # GO_function GO:0003723 RNA binding; IEA:InterPro. # GO_function GO:0004523 RNA-DNA hybrid ribonuclease activity; IDA:EcoCyc. # GO_function GO:0030145 manganese ion binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006298 mismatch repair; IBA:GO_Central. # GO_process GO:0043137 DNA replication, removal of RNA primer; IBA:GO_Central. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0004518 nuclease activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # Gene3D 3.30.420.10 -; 1. # HAMAP MF_00052_B RNase_HII_B # IntAct P10442 5 # InterPro IPR001352 RNase_HII/HIII # InterPro IPR012337 RNaseH-like_dom # InterPro IPR022898 RNase_HII # InterPro IPR024567 RNase_HII/HIII_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03032 DNA replication proteins # KEGG_Pathway ko03030 DNA replication # Organism RNH2_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10954 PTHR10954 # PATRIC 32115477 VBIEscCol129921_0190 # PIR G64742 QQECBE # Pfam PF01351 RNase_HII # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RNH2_ECOLI Ribonuclease HII # RefSeq NP_414725 NC_000913.3 # RefSeq WP_000569430 NZ_LN832404.1 # SIMILARITY Belongs to the RNase HII family. {ECO 0000305}. # SUBCELLULAR LOCATION RNH2_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF53098 SSF53098 # eggNOG COG0164 LUCA # eggNOG ENOG4108UH2 Bacteria BLAST swissprot:RNH2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RNH2_ECOLI BioCyc ECOL316407:JW0178-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0178-MONOMER BioCyc EcoCyc:EG10861-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10861-MONOMER BioCyc MetaCyc:EG10861-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10861-MONOMER COG COG0164 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0164 DOI 10.1021/bi982207z http://dx.doi.org/10.1021/bi982207z DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.87.21.8587 http://dx.doi.org/10.1073/pnas.87.21.8587 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.26.4 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.26.4 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M19334 http://www.ebi.ac.uk/ena/data/view/M19334 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 ENZYME 3.1.26.4 http://enzyme.expasy.org/EC/3.1.26.4 EchoBASE EB0854 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0854 EcoGene EG10861 http://www.ecogene.org/geneInfo.php?eg_id=EG10861 EnsemblBacteria AAC73294 http://www.ensemblgenomes.org/id/AAC73294 EnsemblBacteria AAC73294 http://www.ensemblgenomes.org/id/AAC73294 EnsemblBacteria BAA77858 http://www.ensemblgenomes.org/id/BAA77858 EnsemblBacteria BAA77858 http://www.ensemblgenomes.org/id/BAA77858 EnsemblBacteria BAA77858 http://www.ensemblgenomes.org/id/BAA77858 EnsemblBacteria b0183 http://www.ensemblgenomes.org/id/b0183 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0032299 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032299 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0004523 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004523 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_process GO:0006298 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006298 GO_process GO:0043137 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043137 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 Gene3D 3.30.420.10 http://www.cathdb.info/version/latest/superfamily/3.30.420.10 GeneID 944852 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944852 HAMAP MF_00052_B http://hamap.expasy.org/unirule/MF_00052_B HOGENOM HOG000100288 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000100288&db=HOGENOM6 InParanoid P10442 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P10442 IntAct P10442 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P10442* IntEnz 3.1.26.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.26.4 InterPro IPR001352 http://www.ebi.ac.uk/interpro/entry/IPR001352 InterPro IPR012337 http://www.ebi.ac.uk/interpro/entry/IPR012337 InterPro IPR022898 http://www.ebi.ac.uk/interpro/entry/IPR022898 InterPro IPR024567 http://www.ebi.ac.uk/interpro/entry/IPR024567 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03032 http://www.genome.jp/dbget-bin/www_bget?ko03032 KEGG_Gene ecj:JW0178 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0178 KEGG_Gene eco:b0183 http://www.genome.jp/dbget-bin/www_bget?eco:b0183 KEGG_Orthology KO:K03470 http://www.genome.jp/dbget-bin/www_bget?KO:K03470 KEGG_Pathway ko03030 http://www.genome.jp/kegg-bin/show_pathway?ko03030 OMA LSWAYLD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LSWAYLD PANTHER PTHR10954 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10954 PSORT swissprot:RNH2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RNH2_ECOLI PSORT-B swissprot:RNH2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RNH2_ECOLI PSORT2 swissprot:RNH2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RNH2_ECOLI Pfam PF01351 http://pfam.xfam.org/family/PF01351 Phobius swissprot:RNH2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RNH2_ECOLI PhylomeDB P10442 http://phylomedb.org/?seqid=P10442 ProteinModelPortal P10442 http://www.proteinmodelportal.org/query/uniprot/P10442 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2172991 http://www.ncbi.nlm.nih.gov/pubmed/2172991 PubMed 3316192 http://www.ncbi.nlm.nih.gov/pubmed/3316192 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9888800 http://www.ncbi.nlm.nih.gov/pubmed/9888800 RefSeq NP_414725 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414725 RefSeq WP_000569430 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000569430 SMR P10442 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P10442 STRING 511145.b0183 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0183&targetmode=cogs STRING COG0164 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0164&targetmode=cogs SUPFAM SSF53098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098 UniProtKB RNH2_ECOLI http://www.uniprot.org/uniprot/RNH2_ECOLI UniProtKB-AC P10442 http://www.uniprot.org/uniprot/P10442 charge swissprot:RNH2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RNH2_ECOLI eggNOG COG0164 http://eggnogapi.embl.de/nog_data/html/tree/COG0164 eggNOG ENOG4108UH2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UH2 epestfind swissprot:RNH2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RNH2_ECOLI garnier swissprot:RNH2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RNH2_ECOLI helixturnhelix swissprot:RNH2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RNH2_ECOLI hmoment swissprot:RNH2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RNH2_ECOLI iep swissprot:RNH2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RNH2_ECOLI inforesidue swissprot:RNH2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RNH2_ECOLI octanol swissprot:RNH2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RNH2_ECOLI pepcoil swissprot:RNH2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RNH2_ECOLI pepdigest swissprot:RNH2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RNH2_ECOLI pepinfo swissprot:RNH2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RNH2_ECOLI pepnet swissprot:RNH2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RNH2_ECOLI pepstats swissprot:RNH2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RNH2_ECOLI pepwheel swissprot:RNH2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RNH2_ECOLI pepwindow swissprot:RNH2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RNH2_ECOLI sigcleave swissprot:RNH2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RNH2_ECOLI ## Database ID URL or Descriptions # AltName FLGH_ECOLI Basal body L-ring protein # BioGrid 4261033 6 # EcoGene EG20264 flgH # FUNCTION FLGH_ECOLI Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation. {ECO 0000250}. # GO_component GO:0009279 cell outer membrane; IEA:UniProtKB-SubCell. # GO_component GO:0009427 bacterial-type flagellum basal body, distal rod, L ring; IEA:InterPro. # GO_function GO:0003774 motor activity; IEA:InterPro. # GO_process GO:0006970 response to osmotic stress; IMP:EcoCyc. # GO_process GO:0071973 bacterial-type flagellum-dependent cell motility; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006950 response to stress # GOslim_process GO:0048870 cell motility # HAMAP MF_00415 FlgH # IntAct P0A6S0 13 # InterPro IPR000527 Flag_Lring # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Pathway ko02040 Flagellar assembly # Organism FLGH_ECOLI Escherichia coli (strain K12) # PATRIC 32117399 VBIEscCol129921_1122 # PIR D64851 D64851 # PRINTS PR01008 FLGLRINGFLGH # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF02107 FlgH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FLGH_ECOLI Flagellar L-ring protein # RefSeq NP_415597 NC_000913.3 # RefSeq WP_001295442 NZ_LN832404.1 # SIMILARITY Belongs to the FlgH family. {ECO 0000305}. # SUBCELLULAR LOCATION FLGH_ECOLI Cell outer membrane {ECO 0000250}; Lipid- anchor {ECO 0000250}. Bacterial flagellum basal body {ECO 0000250}. # SUBUNIT The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. {ECO 0000250}. # eggNOG COG2063 LUCA # eggNOG ENOG4107W7W Bacteria BLAST swissprot:FLGH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLGH_ECOLI BioCyc ECOL316407:JW5153-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5153-MONOMER BioCyc EcoCyc:FLGH-FLAGELLAR-L-RING http://biocyc.org/getid?id=EcoCyc:FLGH-FLAGELLAR-L-RING COG COG2063 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2063 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4161 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4161 EcoGene EG20264 http://www.ecogene.org/geneInfo.php?eg_id=EG20264 EnsemblBacteria AAC74163 http://www.ensemblgenomes.org/id/AAC74163 EnsemblBacteria AAC74163 http://www.ensemblgenomes.org/id/AAC74163 EnsemblBacteria BAA35888 http://www.ensemblgenomes.org/id/BAA35888 EnsemblBacteria BAA35888 http://www.ensemblgenomes.org/id/BAA35888 EnsemblBacteria BAA35888 http://www.ensemblgenomes.org/id/BAA35888 EnsemblBacteria b1079 http://www.ensemblgenomes.org/id/b1079 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0009427 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009427 GO_function GO:0003774 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003774 GO_process GO:0006970 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006970 GO_process GO:0071973 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071973 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 GeneID 946996 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946996 HAMAP MF_00415 http://hamap.expasy.org/unirule/MF_00415 HOGENOM HOG000280165 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000280165&db=HOGENOM6 InParanoid P0A6S0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6S0 IntAct P0A6S0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6S0* InterPro IPR000527 http://www.ebi.ac.uk/interpro/entry/IPR000527 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW5153 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5153 KEGG_Gene eco:b1079 http://www.genome.jp/dbget-bin/www_bget?eco:b1079 KEGG_Orthology KO:K02393 http://www.genome.jp/dbget-bin/www_bget?KO:K02393 KEGG_Pathway ko02040 http://www.genome.jp/kegg-bin/show_pathway?ko02040 OMA EGPLGNN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EGPLGNN PRINTS PR01008 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01008 PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:FLGH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLGH_ECOLI PSORT-B swissprot:FLGH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLGH_ECOLI PSORT2 swissprot:FLGH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLGH_ECOLI Pfam PF02107 http://pfam.xfam.org/family/PF02107 Phobius swissprot:FLGH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLGH_ECOLI PhylomeDB P0A6S0 http://phylomedb.org/?seqid=P0A6S0 ProteinModelPortal P0A6S0 http://www.proteinmodelportal.org/query/uniprot/P0A6S0 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415597 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415597 RefSeq WP_001295442 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295442 STRING 511145.b1079 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1079&targetmode=cogs STRING COG2063 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2063&targetmode=cogs UniProtKB FLGH_ECOLI http://www.uniprot.org/uniprot/FLGH_ECOLI UniProtKB-AC P0A6S0 http://www.uniprot.org/uniprot/P0A6S0 charge swissprot:FLGH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLGH_ECOLI eggNOG COG2063 http://eggnogapi.embl.de/nog_data/html/tree/COG2063 eggNOG ENOG4107W7W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107W7W epestfind swissprot:FLGH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLGH_ECOLI garnier swissprot:FLGH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLGH_ECOLI helixturnhelix swissprot:FLGH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLGH_ECOLI hmoment swissprot:FLGH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLGH_ECOLI iep swissprot:FLGH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLGH_ECOLI inforesidue swissprot:FLGH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLGH_ECOLI octanol swissprot:FLGH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLGH_ECOLI pepcoil swissprot:FLGH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLGH_ECOLI pepdigest swissprot:FLGH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLGH_ECOLI pepinfo swissprot:FLGH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLGH_ECOLI pepnet swissprot:FLGH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLGH_ECOLI pepstats swissprot:FLGH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLGH_ECOLI pepwheel swissprot:FLGH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLGH_ECOLI pepwindow swissprot:FLGH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLGH_ECOLI sigcleave swissprot:FLGH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLGH_ECOLI ## Database ID URL or Descriptions # BioGrid 4262612 96 # EcoGene EG12353 yifL # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GOslim_component GO:0005886 plasma membrane # InterPro IPR032831 LPAM_2 # Organism YIFL_ECOLI Escherichia coli (strain K12) # PATRIC 32123117 VBIEscCol129921_3924 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF13627 LPAM_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIFL_ECOLI Uncharacterized lipoprotein YifL # RefSeq WP_000799889 NZ_LN832404.1 # RefSeq YP_588473 NC_000913.3 # SUBCELLULAR LOCATION YIFL_ECOLI Cell membrane {ECO 0000255|PROSITE- ProRule PRU00303}; Lipid-anchor {ECO 0000255|PROSITE- ProRule PRU00303}. # eggNOG COG5567 LUCA # eggNOG ENOG4105S7Z Bacteria BLAST swissprot:YIFL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIFL_ECOLI BioCyc ECOL316407:JW3781-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3781-MONOMER BioCyc EcoCyc:MONOMER0-2693 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2693 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X66782 http://www.ebi.ac.uk/ena/data/view/X66782 EchoBASE EB2257 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2257 EcoGene EG12353 http://www.ecogene.org/geneInfo.php?eg_id=EG12353 EnsemblBacteria ABD18710 http://www.ensemblgenomes.org/id/ABD18710 EnsemblBacteria ABD18710 http://www.ensemblgenomes.org/id/ABD18710 EnsemblBacteria BAE77492 http://www.ensemblgenomes.org/id/BAE77492 EnsemblBacteria BAE77492 http://www.ensemblgenomes.org/id/BAE77492 EnsemblBacteria BAE77492 http://www.ensemblgenomes.org/id/BAE77492 EnsemblBacteria b4558 http://www.ensemblgenomes.org/id/b4558 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 1450304 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1450304 HOGENOM HOG000219138 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219138&db=HOGENOM6 IntAct P0ADN6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADN6* InterPro IPR032831 http://www.ebi.ac.uk/interpro/entry/IPR032831 KEGG_Gene ecj:JW3781 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3781 KEGG_Gene eco:b4558 http://www.genome.jp/dbget-bin/www_bget?eco:b4558 OMA FRSLAVM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FRSLAVM PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YIFL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIFL_ECOLI PSORT-B swissprot:YIFL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIFL_ECOLI PSORT2 swissprot:YIFL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIFL_ECOLI Pfam PF13627 http://pfam.xfam.org/family/PF13627 Phobius swissprot:YIFL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIFL_ECOLI ProteinModelPortal P0ADN6 http://www.proteinmodelportal.org/query/uniprot/P0ADN6 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000799889 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000799889 RefSeq YP_588473 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_588473 STRING 511145.b4558 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4558&targetmode=cogs UniProtKB YIFL_ECOLI http://www.uniprot.org/uniprot/YIFL_ECOLI UniProtKB-AC P0ADN6 http://www.uniprot.org/uniprot/P0ADN6 charge swissprot:YIFL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIFL_ECOLI eggNOG COG5567 http://eggnogapi.embl.de/nog_data/html/tree/COG5567 eggNOG ENOG4105S7Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105S7Z epestfind swissprot:YIFL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIFL_ECOLI garnier swissprot:YIFL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIFL_ECOLI helixturnhelix swissprot:YIFL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIFL_ECOLI hmoment swissprot:YIFL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIFL_ECOLI iep swissprot:YIFL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIFL_ECOLI inforesidue swissprot:YIFL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIFL_ECOLI octanol swissprot:YIFL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIFL_ECOLI pepcoil swissprot:YIFL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIFL_ECOLI pepdigest swissprot:YIFL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIFL_ECOLI pepinfo swissprot:YIFL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIFL_ECOLI pepnet swissprot:YIFL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIFL_ECOLI pepstats swissprot:YIFL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIFL_ECOLI pepwheel swissprot:YIFL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIFL_ECOLI pepwindow swissprot:YIFL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIFL_ECOLI sigcleave swissprot:YIFL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIFL_ECOLI ## Database ID URL or Descriptions # Organism YUAK_ECOLI Escherichia coli (strain K12) # RecName YUAK_ECOLI Uncharacterized protein YuaK # RefSeq NP_061401 NC_002483.1 # RefSeq WP_010892525 NC_002483.1 BLAST swissprot:YUAK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YUAK_ECOLI EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1263518 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263518 PSORT swissprot:YUAK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YUAK_ECOLI PSORT-B swissprot:YUAK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YUAK_ECOLI PSORT2 swissprot:YUAK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YUAK_ECOLI Phobius swissprot:YUAK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YUAK_ECOLI ProteinModelPortal Q9JMS9 http://www.proteinmodelportal.org/query/uniprot/Q9JMS9 RefSeq NP_061401 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061401 RefSeq WP_010892525 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_010892525 UniProtKB YUAK_ECOLI http://www.uniprot.org/uniprot/YUAK_ECOLI UniProtKB-AC Q9JMS9 http://www.uniprot.org/uniprot/Q9JMS9 charge swissprot:YUAK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YUAK_ECOLI epestfind swissprot:YUAK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YUAK_ECOLI garnier swissprot:YUAK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YUAK_ECOLI helixturnhelix swissprot:YUAK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YUAK_ECOLI hmoment swissprot:YUAK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YUAK_ECOLI iep swissprot:YUAK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YUAK_ECOLI inforesidue swissprot:YUAK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YUAK_ECOLI octanol swissprot:YUAK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YUAK_ECOLI pepcoil swissprot:YUAK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YUAK_ECOLI pepdigest swissprot:YUAK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YUAK_ECOLI pepinfo swissprot:YUAK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YUAK_ECOLI pepnet swissprot:YUAK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YUAK_ECOLI pepstats swissprot:YUAK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YUAK_ECOLI pepwheel swissprot:YUAK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YUAK_ECOLI pepwindow swissprot:YUAK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YUAK_ECOLI sigcleave swissprot:YUAK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YUAK_ECOLI ## Database ID URL or Descriptions # BioGrid 4263149 10 # EcoGene EG12191 glnK # FUNCTION GLNK_ECOLI P-II indirectly controls the transcription of the glutamine synthetase gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of GlnA. When P-II is uridylylated to P-II-UMP, these events are reversed. When the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP, which causes the deadenylation of glutamine synthetase by GlnE, so activating the enzyme (By similarity). {ECO 0000250}. # GO_function GO:0000166 nucleotide binding; IEA:UniProtKB-KW. # GO_function GO:0030234 enzyme regulator activity; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045848 positive regulation of nitrogen utilization; IMP:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0030234 enzyme regulator activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.30.70.120 -; 1. # INTERACTION GLNK_ECOLI Self; NbExp=3; IntAct=EBI-559503, EBI-559503; P0A9Z1 glnB; NbExp=3; IntAct=EBI-559503, EBI-551053; P27249 glnD; NbExp=3; IntAct=EBI-559503, EBI-552032; P0AFB5 glnL; NbExp=5; IntAct=EBI-559503, EBI-701156; # IntAct P0AC55 14 # InterPro IPR002187 N-reg_PII # InterPro IPR002332 N-reg_PII_urydylation_site # InterPro IPR011322 N-reg_PII-like_a/b # InterPro IPR015867 N-reg_PII/ATP_PRibTrfase_C # InterPro IPR017918 N-reg_PII_CS # Organism GLNK_ECOLI Escherichia coli (strain K12) # PATRIC 32116055 VBIEscCol129921_0469 # PDB 1GNK X-ray; 2.00 A; A/B=1-112 # PDB 2GNK X-ray; 2.00 A; A=1-112 # PDB 2NS1 X-ray; 1.96 A; B=1-112 # PDB 2NUU X-ray; 2.50 A; G/H/I/J/K/L=1-112 # PIR B64775 B64775 # PIRSF PIRSF039144 GlnB # PRINTS PR00340 PIIGLNB # PROSITE PS00496 PII_GLNB_UMP # PROSITE PS00638 PII_GLNB_CTER # PROSITE PS51343 PII_GLNB_DOM # PTM GLNK_ECOLI Uridylylated/deuridylylated by GlnD. # Pfam PF00543 P-II # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLNK_ECOLI Nitrogen regulatory protein P-II 2 # RefSeq NP_414984 NC_000913.3 # RefSeq WP_000780338 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40206.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the P(II) protein family. {ECO:0000255|PROSITE-ProRule PRU00675}. # SMART SM00938 P-II # SUBUNIT GLNK_ECOLI Homotrimer. # SUPFAM SSF54913 SSF54913 # eggNOG COG0347 LUCA # eggNOG ENOG4108YZA Bacteria BLAST swissprot:GLNK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLNK_ECOLI BioCyc ECOL316407:JW0440-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0440-MONOMER BioCyc EcoCyc:PROTEIN-PII2 http://biocyc.org/getid?id=EcoCyc:PROTEIN-PII2 BioCyc MetaCyc:PROTEIN-PII2 http://biocyc.org/getid?id=MetaCyc:PROTEIN-PII2 COG COG0347 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0347 DIP DIP-35006N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35006N DOI 10.1006/jmbi.1998.1979 http://dx.doi.org/10.1006/jmbi.1998.1979 DOI 10.1016/0378-1119(93)90470-N http://dx.doi.org/10.1016/0378-1119(93)90470-N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1996.6281349.x http://dx.doi.org/10.1046/j.1365-2958.1996.6281349.x DOI 10.1111/j.1574-6968.1995.tb07825.x http://dx.doi.org/10.1111/j.1574-6968.1995.tb07825.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL S79842 http://www.ebi.ac.uk/ena/data/view/S79842 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U40429 http://www.ebi.ac.uk/ena/data/view/U40429 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EchoBASE EB2108 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2108 EcoGene EG12191 http://www.ecogene.org/geneInfo.php?eg_id=EG12191 EnsemblBacteria AAC73553 http://www.ensemblgenomes.org/id/AAC73553 EnsemblBacteria AAC73553 http://www.ensemblgenomes.org/id/AAC73553 EnsemblBacteria BAE76230 http://www.ensemblgenomes.org/id/BAE76230 EnsemblBacteria BAE76230 http://www.ensemblgenomes.org/id/BAE76230 EnsemblBacteria BAE76230 http://www.ensemblgenomes.org/id/BAE76230 EnsemblBacteria b0450 http://www.ensemblgenomes.org/id/b0450 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000166 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000166 GO_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0045848 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045848 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.30.70.120 http://www.cathdb.info/version/latest/superfamily/3.30.70.120 GeneID 945087 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945087 HOGENOM HOG000017847 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000017847&db=HOGENOM6 InParanoid P0AC55 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AC55 IntAct P0AC55 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AC55* InterPro IPR002187 http://www.ebi.ac.uk/interpro/entry/IPR002187 InterPro IPR002332 http://www.ebi.ac.uk/interpro/entry/IPR002332 InterPro IPR011322 http://www.ebi.ac.uk/interpro/entry/IPR011322 InterPro IPR015867 http://www.ebi.ac.uk/interpro/entry/IPR015867 InterPro IPR017918 http://www.ebi.ac.uk/interpro/entry/IPR017918 KEGG_Gene ecj:JW0440 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0440 KEGG_Gene eco:b0450 http://www.genome.jp/dbget-bin/www_bget?eco:b0450 KEGG_Orthology KO:K04752 http://www.genome.jp/dbget-bin/www_bget?KO:K04752 MINT MINT-1309225 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1309225 OMA GGHKEVY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GGHKEVY PDB 1GNK http://www.ebi.ac.uk/pdbe-srv/view/entry/1GNK PDB 2GNK http://www.ebi.ac.uk/pdbe-srv/view/entry/2GNK PDB 2NS1 http://www.ebi.ac.uk/pdbe-srv/view/entry/2NS1 PDB 2NUU http://www.ebi.ac.uk/pdbe-srv/view/entry/2NUU PDBsum 1GNK http://www.ebi.ac.uk/pdbsum/1GNK PDBsum 2GNK http://www.ebi.ac.uk/pdbsum/2GNK PDBsum 2NS1 http://www.ebi.ac.uk/pdbsum/2NS1 PDBsum 2NUU http://www.ebi.ac.uk/pdbsum/2NUU PRINTS PR00340 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00340 PROSITE PS00496 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00496 PROSITE PS00638 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00638 PROSITE PS51343 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51343 PSORT swissprot:GLNK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLNK_ECOLI PSORT-B swissprot:GLNK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLNK_ECOLI PSORT2 swissprot:GLNK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLNK_ECOLI Pfam PF00543 http://pfam.xfam.org/family/PF00543 Phobius swissprot:GLNK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLNK_ECOLI PhylomeDB P0AC55 http://phylomedb.org/?seqid=P0AC55 ProteinModelPortal P0AC55 http://www.proteinmodelportal.org/query/uniprot/P0AC55 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7590157 http://www.ncbi.nlm.nih.gov/pubmed/7590157 PubMed 7904973 http://www.ncbi.nlm.nih.gov/pubmed/7904973 PubMed 8843440 http://www.ncbi.nlm.nih.gov/pubmed/8843440 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9733647 http://www.ncbi.nlm.nih.gov/pubmed/9733647 RefSeq NP_414984 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414984 RefSeq WP_000780338 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000780338 SMART SM00938 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00938 SMR P0AC55 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AC55 STRING 511145.b0450 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0450&targetmode=cogs STRING COG0347 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0347&targetmode=cogs SUPFAM SSF54913 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54913 SWISS-2DPAGE P0AC55 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AC55 UniProtKB GLNK_ECOLI http://www.uniprot.org/uniprot/GLNK_ECOLI UniProtKB-AC P0AC55 http://www.uniprot.org/uniprot/P0AC55 charge swissprot:GLNK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLNK_ECOLI eggNOG COG0347 http://eggnogapi.embl.de/nog_data/html/tree/COG0347 eggNOG ENOG4108YZA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108YZA epestfind swissprot:GLNK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLNK_ECOLI garnier swissprot:GLNK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLNK_ECOLI helixturnhelix swissprot:GLNK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLNK_ECOLI hmoment swissprot:GLNK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLNK_ECOLI iep swissprot:GLNK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLNK_ECOLI inforesidue swissprot:GLNK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLNK_ECOLI octanol swissprot:GLNK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLNK_ECOLI pepcoil swissprot:GLNK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLNK_ECOLI pepdigest swissprot:GLNK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLNK_ECOLI pepinfo swissprot:GLNK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLNK_ECOLI pepnet swissprot:GLNK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLNK_ECOLI pepstats swissprot:GLNK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLNK_ECOLI pepwheel swissprot:GLNK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLNK_ECOLI pepwindow swissprot:GLNK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLNK_ECOLI sigcleave swissprot:GLNK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLNK_ECOLI ## Database ID URL or Descriptions # BioGrid 4260045 8 # EcoGene EG10471 hyaD # FUNCTION HYAD_ECOLI Protease involved in the C-terminal processing of HyaB, the large subunit of hydrogenase 1. {ECO 0000305}. # GO_function GO:0004175 endopeptidase activity; IBA:GO_Central. # GO_function GO:0004190 aspartic-type endopeptidase activity; IEA:UniProtKB-KW. # GO_function GO:0008047 enzyme activator activity; IEA:InterPro. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006464 cellular protein modification process; IBA:GO_Central. # GO_process GO:0016485 protein processing; IMP:EcoCyc. # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0030234 enzyme regulator activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0051604 protein maturation # Gene3D 3.40.50.1450 -; 1. # INTERACTION HYAD_ECOLI P0ACD8 hyaB; NbExp=3; IntAct=EBI-552940, EBI-851493; # IntAct P19930 22 # InterPro IPR000671 Peptidase_A31 # InterPro IPR004419 Pept_A31_hyd_express # InterPro IPR023430 Pept_HybD-like_dom # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # Organism HYAD_ECOLI Escherichia coli (strain K12) # PATRIC 32117171 VBIEscCol129921_1009 # PIR JV0075 QQECHD # PRINTS PR00446 HYDRGNUPTAKE # Pfam PF01750 HycI # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HYAD_ECOLI Hydrogenase 1 maturation protease # RefSeq NP_415494 NC_000913.3 # RefSeq WP_000003671 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase A31 family. {ECO 0000305}. # SUPFAM SSF53163 SSF53163 # TIGRFAMs TIGR00072 hydrog_prot # TIGRFAMs TIGR00140 hupD # eggNOG COG0680 LUCA # eggNOG ENOG4108USZ Bacteria BLAST swissprot:HYAD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HYAD_ECOLI BioCyc ECOL316407:JW0957-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0957-MONOMER BioCyc EcoCyc:EG10471-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10471-MONOMER COG COG0680 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0680 DIP DIP-9960N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9960N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.23.- http://www.genome.jp/dbget-bin/www_bget?EC:3.4.23.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M34825 http://www.ebi.ac.uk/ena/data/view/M34825 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.4.23.- http://enzyme.expasy.org/EC/3.4.23.- EchoBASE EB0466 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0466 EcoGene EG10471 http://www.ecogene.org/geneInfo.php?eg_id=EG10471 EnsemblBacteria AAC74060 http://www.ensemblgenomes.org/id/AAC74060 EnsemblBacteria AAC74060 http://www.ensemblgenomes.org/id/AAC74060 EnsemblBacteria BAA35740 http://www.ensemblgenomes.org/id/BAA35740 EnsemblBacteria BAA35740 http://www.ensemblgenomes.org/id/BAA35740 EnsemblBacteria BAA35740 http://www.ensemblgenomes.org/id/BAA35740 EnsemblBacteria b0975 http://www.ensemblgenomes.org/id/b0975 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004175 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004175 GO_function GO:0004190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004190 GO_function GO:0008047 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008047 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GO_process GO:0016485 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016485 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 Gene3D 3.40.50.1450 http://www.cathdb.info/version/latest/superfamily/3.40.50.1450 GeneID 945575 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945575 HOGENOM HOG000278719 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278719&db=HOGENOM6 InParanoid P19930 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P19930 IntAct P19930 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P19930* IntEnz 3.4.23 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.23 InterPro IPR000671 http://www.ebi.ac.uk/interpro/entry/IPR000671 InterPro IPR004419 http://www.ebi.ac.uk/interpro/entry/IPR004419 InterPro IPR023430 http://www.ebi.ac.uk/interpro/entry/IPR023430 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW0957 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0957 KEGG_Gene eco:b0975 http://www.genome.jp/dbget-bin/www_bget?eco:b0975 KEGG_Orthology KO:K03605 http://www.genome.jp/dbget-bin/www_bget?KO:K03605 MINT MINT-1321337 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1321337 OMA HQTGFQD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HQTGFQD PRINTS PR00446 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00446 PSORT swissprot:HYAD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HYAD_ECOLI PSORT-B swissprot:HYAD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HYAD_ECOLI PSORT2 swissprot:HYAD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HYAD_ECOLI Pfam PF01750 http://pfam.xfam.org/family/PF01750 Phobius swissprot:HYAD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HYAD_ECOLI PhylomeDB P19930 http://phylomedb.org/?seqid=P19930 ProteinModelPortal P19930 http://www.proteinmodelportal.org/query/uniprot/P19930 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2180913 http://www.ncbi.nlm.nih.gov/pubmed/2180913 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415494 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415494 RefSeq WP_000003671 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000003671 SMR P19930 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P19930 STRING 511145.b0975 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0975&targetmode=cogs STRING COG0680 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0680&targetmode=cogs SUPFAM SSF53163 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53163 TIGRFAMs TIGR00072 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00072 TIGRFAMs TIGR00140 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00140 UniProtKB HYAD_ECOLI http://www.uniprot.org/uniprot/HYAD_ECOLI UniProtKB-AC P19930 http://www.uniprot.org/uniprot/P19930 charge swissprot:HYAD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HYAD_ECOLI eggNOG COG0680 http://eggnogapi.embl.de/nog_data/html/tree/COG0680 eggNOG ENOG4108USZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108USZ epestfind swissprot:HYAD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HYAD_ECOLI garnier swissprot:HYAD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HYAD_ECOLI helixturnhelix swissprot:HYAD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HYAD_ECOLI hmoment swissprot:HYAD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HYAD_ECOLI iep swissprot:HYAD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HYAD_ECOLI inforesidue swissprot:HYAD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HYAD_ECOLI octanol swissprot:HYAD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HYAD_ECOLI pepcoil swissprot:HYAD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HYAD_ECOLI pepdigest swissprot:HYAD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HYAD_ECOLI pepinfo swissprot:HYAD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HYAD_ECOLI pepnet swissprot:HYAD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HYAD_ECOLI pepstats swissprot:HYAD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HYAD_ECOLI pepwheel swissprot:HYAD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HYAD_ECOLI pepwindow swissprot:HYAD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HYAD_ECOLI sigcleave swissprot:HYAD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HYAD_ECOLI ## Database ID URL or Descriptions # BioGrid 4263328 12 # COFACTOR FRVX_ECOLI Name=a divalent metal cation; Xref=ChEBI CHEBI 60240; Evidence={ECO 0000250}; Note=Binds 2 divalent metal cations per subunit. {ECO 0000250}; # EcoGene EG11862 frvX # GO_function GO:0004177 aminopeptidase activity; IEA:UniProtKB-KW. # GO_function GO:0008237 metallopeptidase activity; IEA:UniProtKB-KW. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0043167 ion binding # Gene3D 2.40.30.40 -; 1. # IntAct P32153 3 # InterPro IPR008007 Peptidase_M42 # InterPro IPR023367 Peptidase_M42_dom2 # Organism FRVX_ECOLI Escherichia coli (strain K12) # PATRIC 32123305 VBIEscCol129921_4013 # PIR S40842 S40842 # PIRSF PIRSF001123 PepA_GA # Pfam PF05343 Peptidase_M42 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FRVX_ECOLI Putative aminopeptidase FrvX # RefSeq NP_418334 NC_000913.3 # RefSeq WP_001019484 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase M42 family. {ECO 0000305}. # eggNOG COG1363 LUCA # eggNOG ENOG4105CN9 Bacteria BLAST swissprot:FRVX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FRVX_ECOLI BioCyc ECOL316407:JW3869-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3869-MONOMER BioCyc EcoCyc:EG11862-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11862-MONOMER DIP DIP-9694N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9694N DOI 10.1002/pro.5560030309 http://dx.doi.org/10.1002/pro.5560030309 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.11.- http://www.genome.jp/dbget-bin/www_bget?EC:3.4.11.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.4.11.- http://enzyme.expasy.org/EC/3.4.11.- EchoBASE EB1808 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1808 EcoGene EG11862 http://www.ecogene.org/geneInfo.php?eg_id=EG11862 EnsemblBacteria AAC76880 http://www.ensemblgenomes.org/id/AAC76880 EnsemblBacteria AAC76880 http://www.ensemblgenomes.org/id/AAC76880 EnsemblBacteria BAE77411 http://www.ensemblgenomes.org/id/BAE77411 EnsemblBacteria BAE77411 http://www.ensemblgenomes.org/id/BAE77411 EnsemblBacteria BAE77411 http://www.ensemblgenomes.org/id/BAE77411 EnsemblBacteria b3898 http://www.ensemblgenomes.org/id/b3898 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004177 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004177 GO_function GO:0008237 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008237 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 2.40.30.40 http://www.cathdb.info/version/latest/superfamily/2.40.30.40 GeneID 948388 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948388 HOGENOM HOG000291973 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000291973&db=HOGENOM6 InParanoid P32153 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32153 IntAct P32153 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32153* IntEnz 3.4.11 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.11 InterPro IPR008007 http://www.ebi.ac.uk/interpro/entry/IPR008007 InterPro IPR023367 http://www.ebi.ac.uk/interpro/entry/IPR023367 KEGG_Gene ecj:JW3869 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3869 KEGG_Gene eco:b3898 http://www.genome.jp/dbget-bin/www_bget?eco:b3898 OMA FTVMNNE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FTVMNNE PSORT swissprot:FRVX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FRVX_ECOLI PSORT-B swissprot:FRVX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FRVX_ECOLI PSORT2 swissprot:FRVX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FRVX_ECOLI Pfam PF05343 http://pfam.xfam.org/family/PF05343 Phobius swissprot:FRVX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FRVX_ECOLI PhylomeDB P32153 http://phylomedb.org/?seqid=P32153 ProteinModelPortal P32153 http://www.proteinmodelportal.org/query/uniprot/P32153 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8019415 http://www.ncbi.nlm.nih.gov/pubmed/8019415 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418334 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418334 RefSeq WP_001019484 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001019484 SMR P32153 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32153 STRING 511145.b3898 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3898&targetmode=cogs UniProtKB FRVX_ECOLI http://www.uniprot.org/uniprot/FRVX_ECOLI UniProtKB-AC P32153 http://www.uniprot.org/uniprot/P32153 charge swissprot:FRVX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FRVX_ECOLI eggNOG COG1363 http://eggnogapi.embl.de/nog_data/html/tree/COG1363 eggNOG ENOG4105CN9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CN9 epestfind swissprot:FRVX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FRVX_ECOLI garnier swissprot:FRVX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FRVX_ECOLI helixturnhelix swissprot:FRVX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FRVX_ECOLI hmoment swissprot:FRVX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FRVX_ECOLI iep swissprot:FRVX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FRVX_ECOLI inforesidue swissprot:FRVX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FRVX_ECOLI octanol swissprot:FRVX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FRVX_ECOLI pepcoil swissprot:FRVX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FRVX_ECOLI pepdigest swissprot:FRVX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FRVX_ECOLI pepinfo swissprot:FRVX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FRVX_ECOLI pepnet swissprot:FRVX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FRVX_ECOLI pepstats swissprot:FRVX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FRVX_ECOLI pepwheel swissprot:FRVX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FRVX_ECOLI pepwindow swissprot:FRVX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FRVX_ECOLI sigcleave swissprot:FRVX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FRVX_ECOLI ## Database ID URL or Descriptions # AltName Bacteriophage N4 adsorption protein C {ECO:0000305|PubMed 8226648} # AltName UDP-GlcNAc-2-epimerase {ECO:0000255|HAMAP-Rule MF_02028, ECO:0000305} # BIOPHYSICOCHEMICAL PROPERTIES WECB_ECOLI Kinetic parameters KM=0.6 mM for UDP-GlcNAc {ECO 0000269|PubMed 15210128}; Note=kcat is 7.1 sec(-1). {ECO 0000269|PubMed 15210128}; # BRENDA 3.2.1.183 1960 # BRENDA 5.1.3.14 2026 # BioGrid 4263321 147 # CATALYTIC ACTIVITY WECB_ECOLI UDP-N-acetyl-alpha-D-glucosamine = UDP-N- acetyl-alpha-D-mannosamine. {ECO 0000255|HAMAP-Rule MF_02028, ECO 0000269|PubMed 15210128, ECO 0000269|Ref.9}. # CDD cd03786 GT1_UDP-GlcNAc_2-Epimerase # ENZYME REGULATION Allosterically activated by its substrate, UDP- GlcNAc. {ECO:0000269|PubMed 15210128}. # EcoGene EG11451 wecB # FUNCTION WECB_ECOLI Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues. Also involved in bacteriophage N4 adsorption. {ECO 0000269|PubMed 15210128, ECO 0000269|PubMed 7559340, ECO 0000269|PubMed 8170390, ECO 0000269|PubMed 8226648, ECO 0000269|Ref.9}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008761 UDP-N-acetylglucosamine 2-epimerase activity; IMP:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0009246 enterobacterial common antigen biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # HAMAP MF_02028 WecB_RffE # InterPro IPR003331 UDP_GlcNAc_Epimerase_2_dom # InterPro IPR029767 WecB-like # InterPro IPR032892 WecB # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # KEGG_Pathway ko00520 Amino sugar and nucleotide sugar metabolism # Organism WECB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR18964:SF2 PTHR18964:SF2 # PATHWAY WECB_ECOLI Bacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis. {ECO 0000255|HAMAP-Rule MF_02028, ECO 0000305|PubMed 2166030}. # PATRIC 32123065 VBIEscCol129921_3902 # PDB 1F6D X-ray; 2.50 A; A/B/C/D=1-376 # PDB 1VGV X-ray; 2.31 A; A/B/C/D=2-376 # PIR E65182 E65182 # Pfam PF02350 Epimerase_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UDP-N-acetylglucosamine 2-epimerase {ECO:0000255|HAMAP-Rule MF_02028, ECO:0000305} # RefSeq YP_026253 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA67586.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the UDP-N-acetylglucosamine 2-epimerase family. {ECO:0000255|HAMAP-Rule MF_02028, ECO:0000305}. # SUBCELLULAR LOCATION WECB_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_02028, ECO 0000269|PubMed 8226648}. # SUBUNIT WECB_ECOLI Homodimer. {ECO 0000255|HAMAP-Rule MF_02028, ECO 0000269|PubMed 11106477}. # TIGRFAMs TIGR00236 wecB # eggNOG COG0381 LUCA # eggNOG ENOG4105EAG Bacteria BLAST swissprot:WECB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:WECB_ECOLI BioCyc ECOL316407:JW5600-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5600-MONOMER BioCyc EcoCyc:UDPGLCNACEPIM-MONOMER http://biocyc.org/getid?id=EcoCyc:UDPGLCNACEPIM-MONOMER BioCyc MetaCyc:UDPGLCNACEPIM-MONOMER http://biocyc.org/getid?id=MetaCyc:UDPGLCNACEPIM-MONOMER COG COG0381 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0381 DOI 10.1002/prot.20541 http://dx.doi.org/10.1002/prot.20541 DOI 10.1016/j.bbapap.2004.03.017 http://dx.doi.org/10.1016/j.bbapap.2004.03.017 DOI 10.1021/bi001627x http://dx.doi.org/10.1021/bi001627x DOI 10.1021/ja960266z http://dx.doi.org/10.1021/ja960266z DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1111/j.1365-2958.1994.tb00308.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb00308.x DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.1.3.14 {ECO:0000255|HAMAP-Rule:MF_02028, ECO:0000269|PubMed:15210128, ECO:0000269|Ref.9} http://www.genome.jp/dbget-bin/www_bget?EC:5.1.3.14 {ECO:0000255|HAMAP-Rule:MF_02028, ECO:0000269|PubMed:15210128, ECO:0000269|Ref.9} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L18799 http://www.ebi.ac.uk/ena/data/view/L18799 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 5.1.3.14 {ECO:0000255|HAMAP-Rule:MF_02028, ECO:0000269|PubMed:15210128, ECO:0000269|Ref.9} http://enzyme.expasy.org/EC/5.1.3.14 {ECO:0000255|HAMAP-Rule:MF_02028, ECO:0000269|PubMed:15210128, ECO:0000269|Ref.9} EchoBASE EB1420 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1420 EcoGene EG11451 http://www.ecogene.org/geneInfo.php?eg_id=EG11451 EnsemblBacteria AAT48211 http://www.ensemblgenomes.org/id/AAT48211 EnsemblBacteria AAT48211 http://www.ensemblgenomes.org/id/AAT48211 EnsemblBacteria BAE77512 http://www.ensemblgenomes.org/id/BAE77512 EnsemblBacteria BAE77512 http://www.ensemblgenomes.org/id/BAE77512 EnsemblBacteria BAE77512 http://www.ensemblgenomes.org/id/BAE77512 EnsemblBacteria b3786 http://www.ensemblgenomes.org/id/b3786 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008761 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008761 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0009246 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009246 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 944789 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944789 HAMAP MF_02028 http://hamap.expasy.org/unirule/MF_02028 HOGENOM HOG000076048 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000076048&db=HOGENOM6 InParanoid P27828 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P27828 IntEnz 5.1.3.14 {ECO:0000255|HAMAP-Rule:MF_02028, ECO:0000269|PubMed:15210128, ECO:0000269|Ref.9} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.1.3.14 {ECO:0000255|HAMAP-Rule:MF_02028, ECO:0000269|PubMed:15210128, ECO:0000269|Ref.9} InterPro IPR003331 http://www.ebi.ac.uk/interpro/entry/IPR003331 InterPro IPR029767 http://www.ebi.ac.uk/interpro/entry/IPR029767 InterPro IPR032892 http://www.ebi.ac.uk/interpro/entry/IPR032892 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Gene ecj:JW5600 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5600 KEGG_Gene eco:b3786 http://www.genome.jp/dbget-bin/www_bget?eco:b3786 KEGG_Orthology KO:K01791 http://www.genome.jp/dbget-bin/www_bget?KO:K01791 KEGG_Pathway ko00520 http://www.genome.jp/kegg-bin/show_pathway?ko00520 KEGG_Reaction rn:R00414 http://www.genome.jp/dbget-bin/www_bget?rn:R00414 KEGG_Reaction rn:R00420 http://www.genome.jp/dbget-bin/www_bget?rn:R00420 OMA IMKERQT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IMKERQT PANTHER PTHR18964:SF2 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18964:SF2 PDB 1F6D http://www.ebi.ac.uk/pdbe-srv/view/entry/1F6D PDB 1VGV http://www.ebi.ac.uk/pdbe-srv/view/entry/1VGV PDBsum 1F6D http://www.ebi.ac.uk/pdbsum/1F6D PDBsum 1VGV http://www.ebi.ac.uk/pdbsum/1VGV PSORT swissprot:WECB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:WECB_ECOLI PSORT-B swissprot:WECB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:WECB_ECOLI PSORT2 swissprot:WECB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:WECB_ECOLI Pfam PF02350 http://pfam.xfam.org/family/PF02350 Phobius swissprot:WECB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:WECB_ECOLI PhylomeDB P27828 http://phylomedb.org/?seqid=P27828 ProteinModelPortal P27828 http://www.proteinmodelportal.org/query/uniprot/P27828 PubMed 11106477 http://www.ncbi.nlm.nih.gov/pubmed/11106477 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 15210128 http://www.ncbi.nlm.nih.gov/pubmed/15210128 PubMed 16021622 http://www.ncbi.nlm.nih.gov/pubmed/16021622 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2166030 http://www.ncbi.nlm.nih.gov/pubmed/2166030 PubMed 7559340 http://www.ncbi.nlm.nih.gov/pubmed/7559340 PubMed 8170390 http://www.ncbi.nlm.nih.gov/pubmed/8170390 PubMed 8226648 http://www.ncbi.nlm.nih.gov/pubmed/8226648 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq YP_026253 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026253 SMR P27828 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P27828 STRING 511145.b3786 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3786&targetmode=cogs STRING COG0381 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0381&targetmode=cogs TIGRFAMs TIGR00236 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00236 UniProtKB WECB_ECOLI http://www.uniprot.org/uniprot/WECB_ECOLI UniProtKB-AC P27828 http://www.uniprot.org/uniprot/P27828 charge swissprot:WECB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:WECB_ECOLI eggNOG COG0381 http://eggnogapi.embl.de/nog_data/html/tree/COG0381 eggNOG ENOG4105EAG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EAG epestfind swissprot:WECB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:WECB_ECOLI garnier swissprot:WECB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:WECB_ECOLI helixturnhelix swissprot:WECB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:WECB_ECOLI hmoment swissprot:WECB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:WECB_ECOLI iep swissprot:WECB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:WECB_ECOLI inforesidue swissprot:WECB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:WECB_ECOLI octanol swissprot:WECB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:WECB_ECOLI pepcoil swissprot:WECB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:WECB_ECOLI pepdigest swissprot:WECB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:WECB_ECOLI pepinfo swissprot:WECB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:WECB_ECOLI pepnet swissprot:WECB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:WECB_ECOLI pepstats swissprot:WECB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:WECB_ECOLI pepwheel swissprot:WECB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:WECB_ECOLI pepwindow swissprot:WECB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:WECB_ECOLI sigcleave swissprot:WECB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:WECB_ECOLI ## Database ID URL or Descriptions # AltName YFCG_ECOLI GSH-dependent disulfide-bond oxidoreductase YfcG # AltName YFCG_ECOLI GST N1-1 # AltName YFCG_ECOLI GST-like protein YfcG # AltName YFCG_ECOLI Organic hydroperoxidase # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=1.6 mM for glutathione (when assaying the disulfide-bond reductase activity with 2-hydroxyethyl disulfide) {ECO 0000269|PubMed:19537707}; Note=kcat is 180 sec(-1) for the disulfide-bond reductase reaction toward 2-hydroxyethyl disulfide. kcat is 0.27 sec(-1) for the hydroperoxidase reaction with cumene hydroperoxide. kcat is 0.1 sec(-1) for the GSH transferase reaction with chloro-2,4- dinitrobenzene (CDNB) as substrate.; # BioGrid 4260517 13 # DISRUPTION PHENOTYPE Deletion of yfcG decreases the resistance of the bacteria to hydrogen peroxide. {ECO:0000269|PubMed 17018556}. # EcoGene EG14110 yfcG # FUNCTION YFCG_ECOLI Exhibits a very robust glutathione (GSH)-dependent disulfide-bond reductase activity toward the model substrate, 2- hydroxyethyl disulfide; the actual physiological substrates are not known. Has also a low GSH-dependent hydroperoxidase activity toward cumene hydroperoxide, but does not reduce H(2)O(2), tert- butyl hydroperoxide, benzyl peroxide, or lauroyl peroxide. Exhibits little or no GSH transferase activity with most typical electrophilic substrates, and has no detectable transferase activity using glutathionylspermidine (GspSH) as the nucleophilic substrate. Is involved in defense against oxidative stress, probably via its peroxidase activity. {ECO 0000269|PubMed 17018556, ECO 0000269|PubMed 19537707}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0004364 glutathione transferase activity; IBA:GO_Central. # GO_function GO:0004601 peroxidase activity; IEA:UniProtKB-KW. # GO_function GO:0015036 disulfide oxidoreductase activity; IDA:EcoCyc. # GO_process GO:0006749 glutathione metabolic process; IBA:GO_Central. # GO_process GO:0006979 response to oxidative stress; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.20.1050.10 -; 1. # Gene3D 3.40.30.10 -; 1. # IntAct P77526 2 # InterPro IPR004045 Glutathione_S-Trfase_N # InterPro IPR004046 GST_C # InterPro IPR010987 Glutathione-S-Trfase_C-like # InterPro IPR012336 Thioredoxin-like_fold # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00480 Glutathione metabolism # KEGG_Pathway ko00980 Metabolism of xenobiotics by cytochrome P450 # KEGG_Pathway ko00982 Drug metabolism - cytochrome P450 # KEGG_Pathway ko05204 Chemical carcinogenesis # MISCELLANEOUS Glutathionylspermidine (GspSH) binds YfcG about 10 times more tightly than GSH. Moreover, GSSG binds 100 times more tightly than GSH and 10 times more tightly than the GSH analog, GSO(3-) (PubMed:19537707). {ECO 0000305|PubMed:19537707}. # MISCELLANEOUS The reductase activity of YfcG is unique in that no sulfhydryl groups in the protein appear to be covalently involved in the redox chemistry. {ECO:0000305|PubMed 19537707}. # Organism YFCG_ECOLI Escherichia coli (strain K12) # PATRIC 32119975 VBIEscCol129921_2397 # PDB 3GX0 X-ray; 2.30 A; A=1-215 # PDB 5HFK X-ray; 1.55 A; A/B=1-215 # PIR D65002 D65002 # PROSITE PS50404 GST_NTER # PROSITE PS50405 GST_CTER # Pfam PF00043 GST_C # Pfam PF02798 GST_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFCG_ECOLI Disulfide-bond oxidoreductase YfcG # RefSeq NP_416805 NC_000913.3 # RefSeq WP_000566471 NZ_LN832404.1 # SIMILARITY Belongs to the GST superfamily. Nu-class GSH transferase family. {ECO 0000305}. # SIMILARITY Contains 1 GST C-terminal domain. {ECO 0000305}. # SIMILARITY Contains 1 GST N-terminal domain. {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000305|PubMed 19537707}. # SUPFAM SSF47616 SSF47616 # SUPFAM SSF52833 SSF52833 # eggNOG COG0625 LUCA # eggNOG ENOG4105CYM Bacteria BLAST swissprot:YFCG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFCG_ECOLI BioCyc ECOL316407:JW2299-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2299-MONOMER BioCyc EcoCyc:G7194-MONOMER http://biocyc.org/getid?id=EcoCyc:G7194-MONOMER BioCyc MetaCyc:G7194-MONOMER http://biocyc.org/getid?id=MetaCyc:G7194-MONOMER COG COG0625 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0625 DOI 10.1021/bi101861a http://dx.doi.org/10.1021/bi101861a DOI 10.1021/bi9008825 http://dx.doi.org/10.1021/bi9008825 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/jb/mvj199 http://dx.doi.org/10.1093/jb/mvj199 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.11.1.- http://www.genome.jp/dbget-bin/www_bget?EC:1.11.1.- EC_number EC:1.8.4.- http://www.genome.jp/dbget-bin/www_bget?EC:1.8.4.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.11.1.- http://enzyme.expasy.org/EC/1.11.1.- ENZYME 1.8.4.- http://enzyme.expasy.org/EC/1.8.4.- EchoBASE EB3863 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3863 EcoGene EG14110 http://www.ecogene.org/geneInfo.php?eg_id=EG14110 EnsemblBacteria AAC75362 http://www.ensemblgenomes.org/id/AAC75362 EnsemblBacteria AAC75362 http://www.ensemblgenomes.org/id/AAC75362 EnsemblBacteria BAA16139 http://www.ensemblgenomes.org/id/BAA16139 EnsemblBacteria BAA16139 http://www.ensemblgenomes.org/id/BAA16139 EnsemblBacteria BAA16139 http://www.ensemblgenomes.org/id/BAA16139 EnsemblBacteria b2302 http://www.ensemblgenomes.org/id/b2302 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004364 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004364 GO_function GO:0004601 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004601 GO_function GO:0015036 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015036 GO_process GO:0006749 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006749 GO_process GO:0006979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016765 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.20.1050.10 http://www.cathdb.info/version/latest/superfamily/1.20.1050.10 Gene3D 3.40.30.10 http://www.cathdb.info/version/latest/superfamily/3.40.30.10 GeneID 946763 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946763 HOGENOM HOG000125752 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125752&db=HOGENOM6 InParanoid P77526 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77526 IntAct P77526 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77526* IntEnz 1.11.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.11.1 IntEnz 1.8.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.8.4 InterPro IPR004045 http://www.ebi.ac.uk/interpro/entry/IPR004045 InterPro IPR004046 http://www.ebi.ac.uk/interpro/entry/IPR004046 InterPro IPR010987 http://www.ebi.ac.uk/interpro/entry/IPR010987 InterPro IPR012336 http://www.ebi.ac.uk/interpro/entry/IPR012336 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2299 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2299 KEGG_Gene eco:b2302 http://www.genome.jp/dbget-bin/www_bget?eco:b2302 KEGG_Orthology KO:K00799 http://www.genome.jp/dbget-bin/www_bget?KO:K00799 KEGG_Pathway ko00480 http://www.genome.jp/kegg-bin/show_pathway?ko00480 KEGG_Pathway ko00980 http://www.genome.jp/kegg-bin/show_pathway?ko00980 KEGG_Pathway ko00982 http://www.genome.jp/kegg-bin/show_pathway?ko00982 KEGG_Pathway ko05204 http://www.genome.jp/kegg-bin/show_pathway?ko05204 KEGG_Reaction rn:R03522 http://www.genome.jp/dbget-bin/www_bget?rn:R03522 KEGG_Reaction rn:R07002 http://www.genome.jp/dbget-bin/www_bget?rn:R07002 KEGG_Reaction rn:R07003 http://www.genome.jp/dbget-bin/www_bget?rn:R07003 KEGG_Reaction rn:R07004 http://www.genome.jp/dbget-bin/www_bget?rn:R07004 KEGG_Reaction rn:R07023 http://www.genome.jp/dbget-bin/www_bget?rn:R07023 KEGG_Reaction rn:R07024 http://www.genome.jp/dbget-bin/www_bget?rn:R07024 KEGG_Reaction rn:R07025 http://www.genome.jp/dbget-bin/www_bget?rn:R07025 KEGG_Reaction rn:R07026 http://www.genome.jp/dbget-bin/www_bget?rn:R07026 KEGG_Reaction rn:R07069 http://www.genome.jp/dbget-bin/www_bget?rn:R07069 KEGG_Reaction rn:R07070 http://www.genome.jp/dbget-bin/www_bget?rn:R07070 KEGG_Reaction rn:R07083 http://www.genome.jp/dbget-bin/www_bget?rn:R07083 KEGG_Reaction rn:R07084 http://www.genome.jp/dbget-bin/www_bget?rn:R07084 KEGG_Reaction rn:R07091 http://www.genome.jp/dbget-bin/www_bget?rn:R07091 KEGG_Reaction rn:R07092 http://www.genome.jp/dbget-bin/www_bget?rn:R07092 KEGG_Reaction rn:R07093 http://www.genome.jp/dbget-bin/www_bget?rn:R07093 KEGG_Reaction rn:R07094 http://www.genome.jp/dbget-bin/www_bget?rn:R07094 KEGG_Reaction rn:R07100 http://www.genome.jp/dbget-bin/www_bget?rn:R07100 KEGG_Reaction rn:R07113 http://www.genome.jp/dbget-bin/www_bget?rn:R07113 KEGG_Reaction rn:R07116 http://www.genome.jp/dbget-bin/www_bget?rn:R07116 KEGG_Reaction rn:R08280 http://www.genome.jp/dbget-bin/www_bget?rn:R08280 KEGG_Reaction rn:R09409 http://www.genome.jp/dbget-bin/www_bget?rn:R09409 OMA HFSQYAP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HFSQYAP PDB 3GX0 http://www.ebi.ac.uk/pdbe-srv/view/entry/3GX0 PDB 5HFK http://www.ebi.ac.uk/pdbe-srv/view/entry/5HFK PDBsum 3GX0 http://www.ebi.ac.uk/pdbsum/3GX0 PDBsum 5HFK http://www.ebi.ac.uk/pdbsum/5HFK PROSITE PS50404 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50404 PROSITE PS50405 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50405 PSORT swissprot:YFCG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFCG_ECOLI PSORT-B swissprot:YFCG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFCG_ECOLI PSORT2 swissprot:YFCG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFCG_ECOLI Pfam PF00043 http://pfam.xfam.org/family/PF00043 Pfam PF02798 http://pfam.xfam.org/family/PF02798 Phobius swissprot:YFCG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFCG_ECOLI PhylomeDB P77526 http://phylomedb.org/?seqid=P77526 ProteinModelPortal P77526 http://www.proteinmodelportal.org/query/uniprot/P77526 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17018556 http://www.ncbi.nlm.nih.gov/pubmed/17018556 PubMed 19537707 http://www.ncbi.nlm.nih.gov/pubmed/19537707 PubMed 21222452 http://www.ncbi.nlm.nih.gov/pubmed/21222452 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416805 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416805 RefSeq WP_000566471 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000566471 SMR P77526 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77526 STRING 511145.b2302 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2302&targetmode=cogs STRING COG0625 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0625&targetmode=cogs SUPFAM SSF47616 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47616 SUPFAM SSF52833 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52833 UniProtKB YFCG_ECOLI http://www.uniprot.org/uniprot/YFCG_ECOLI UniProtKB-AC P77526 http://www.uniprot.org/uniprot/P77526 charge swissprot:YFCG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFCG_ECOLI eggNOG COG0625 http://eggnogapi.embl.de/nog_data/html/tree/COG0625 eggNOG ENOG4105CYM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CYM epestfind swissprot:YFCG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFCG_ECOLI garnier swissprot:YFCG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFCG_ECOLI helixturnhelix swissprot:YFCG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFCG_ECOLI hmoment swissprot:YFCG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFCG_ECOLI iep swissprot:YFCG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFCG_ECOLI inforesidue swissprot:YFCG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFCG_ECOLI octanol swissprot:YFCG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFCG_ECOLI pepcoil swissprot:YFCG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFCG_ECOLI pepdigest swissprot:YFCG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFCG_ECOLI pepinfo swissprot:YFCG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFCG_ECOLI pepnet swissprot:YFCG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFCG_ECOLI pepstats swissprot:YFCG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFCG_ECOLI pepwheel swissprot:YFCG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFCG_ECOLI pepwindow swissprot:YFCG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFCG_ECOLI sigcleave swissprot:YFCG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFCG_ECOLI ## Database ID URL or Descriptions # CAUTION YEHW_ECOLI Was originally thought to be part of an osmoprotectant uptake system (PubMed 15251200). However, it was shown later that the complex does not mediate osmotic stress protection (PubMed 26325238). {ECO 0000305|PubMed 15251200, ECO 0000305|PubMed 26325238}. # CDD cd06261 TM_PBP2 # EcoGene EG12009 yehW # FUNCTION YEHW_ECOLI Part of an ABC transporter complex involved in low- affinity glycine betaine uptake. Probably responsible for the translocation of the substrate across the membrane. {ECO 0000269|PubMed 26325238}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005215 transporter activity; IBA:GO_Central. # GO_process GO:0006865 amino acid transport; IEA:UniProtKB-KW. # GO_process GO:0031460 glycine betaine transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006810 transport # Gene3D 1.10.3720.10 -; 1. # INDUCTION Expression is sigma S-dependent. Induced by both osmotic shock and entry into stationary phase. {ECO:0000269|PubMed 15251200}. # InterPro IPR000515 MetI-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00209 Osmoprotectant transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism YEHW_ECOLI Escherichia coli (strain K12) # PATRIC 32119595 VBIEscCol129921_2208 # PIR G64980 G64980 # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Glycine betaine uptake system permease protein YehW {ECO 0000305} # RefSeq NP_416632 NC_000913.3 # RefSeq WP_000783123 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION YEHW_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255}. # SUBUNIT The complex is composed of two ATP-binding proteins (YehX), two transmembrane proteins (YehW and YehY) and a solute- binding protein (YehZ). {ECO 0000305}. # SUPFAM SSF161098 SSF161098 # TCDB 3.A.1.12.15 the atp-binding cassette (abc) superfamily # eggNOG COG1174 LUCA # eggNOG ENOG4105WJV Bacteria BLAST swissprot:YEHW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEHW_ECOLI BioCyc ECOL316407:JW2116-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2116-MONOMER BioCyc EcoCyc:YEHW-MONOMER http://biocyc.org/getid?id=EcoCyc:YEHW-MONOMER BioCyc MetaCyc:YEHW-MONOMER http://biocyc.org/getid?id=MetaCyc:YEHW-MONOMER COG COG1174 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1174 DOI 10.1016/j.femsle.2004.05.046 http://dx.doi.org/10.1016/j.femsle.2004.05.046 DOI 10.1021/acs.biochem.5b00274 http://dx.doi.org/10.1021/acs.biochem.5b00274 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1947 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1947 EcoGene EG12009 http://www.ecogene.org/geneInfo.php?eg_id=EG12009 EnsemblBacteria AAC75189 http://www.ensemblgenomes.org/id/AAC75189 EnsemblBacteria AAC75189 http://www.ensemblgenomes.org/id/AAC75189 EnsemblBacteria BAE76605 http://www.ensemblgenomes.org/id/BAE76605 EnsemblBacteria BAE76605 http://www.ensemblgenomes.org/id/BAE76605 EnsemblBacteria BAE76605 http://www.ensemblgenomes.org/id/BAE76605 EnsemblBacteria b2128 http://www.ensemblgenomes.org/id/b2128 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_process GO:0006865 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865 GO_process GO:0031460 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031460 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 949028 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949028 HOGENOM HOG000012909 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000012909&db=HOGENOM6 InParanoid P33359 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33359 InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2116 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2116 KEGG_Gene eco:b2128 http://www.genome.jp/dbget-bin/www_bget?eco:b2128 KEGG_Orthology KO:K05846 http://www.genome.jp/dbget-bin/www_bget?KO:K05846 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA PIFENTV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PIFENTV PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:YEHW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEHW_ECOLI PSORT-B swissprot:YEHW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEHW_ECOLI PSORT2 swissprot:YEHW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEHW_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Phobius swissprot:YEHW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEHW_ECOLI PhylomeDB P33359 http://phylomedb.org/?seqid=P33359 ProteinModelPortal P33359 http://www.proteinmodelportal.org/query/uniprot/P33359 PubMed 15251200 http://www.ncbi.nlm.nih.gov/pubmed/15251200 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 26325238 http://www.ncbi.nlm.nih.gov/pubmed/26325238 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416632 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416632 RefSeq WP_000783123 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000783123 SMR P33359 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33359 STRING 511145.b2128 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2128&targetmode=cogs STRING COG1174 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1174&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.12.15 http://www.tcdb.org/search/result.php?tc=3.A.1.12.15 UniProtKB YEHW_ECOLI http://www.uniprot.org/uniprot/YEHW_ECOLI UniProtKB-AC P33359 http://www.uniprot.org/uniprot/P33359 charge swissprot:YEHW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEHW_ECOLI eggNOG COG1174 http://eggnogapi.embl.de/nog_data/html/tree/COG1174 eggNOG ENOG4105WJV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105WJV epestfind swissprot:YEHW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEHW_ECOLI garnier swissprot:YEHW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEHW_ECOLI helixturnhelix swissprot:YEHW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEHW_ECOLI hmoment swissprot:YEHW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEHW_ECOLI iep swissprot:YEHW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEHW_ECOLI inforesidue swissprot:YEHW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEHW_ECOLI octanol swissprot:YEHW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEHW_ECOLI pepcoil swissprot:YEHW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEHW_ECOLI pepdigest swissprot:YEHW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEHW_ECOLI pepinfo swissprot:YEHW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEHW_ECOLI pepnet swissprot:YEHW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEHW_ECOLI pepstats swissprot:YEHW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEHW_ECOLI pepwheel swissprot:YEHW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEHW_ECOLI pepwindow swissprot:YEHW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEHW_ECOLI sigcleave swissprot:YEHW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEHW_ECOLI ## Database ID URL or Descriptions # EcoGene EG14487 yqcG # GO_process GO:0036460 cellular response to cell envelope stress; IMP:EcoCyc. # GOslim_process GO:0006950 response to stress # INDUCTION In exponential phase (at protein level). {ECO:0000269|PubMed 19121005}. # Organism YQCG_ECOLI Escherichia coli (strain K12) # PATRIC 32120970 VBIEscCol129921_2877 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQCG_ECOLI Uncharacterized protein YqcG # RefSeq WP_001288228 NZ_LN832404.1 # RefSeq YP_002791252 NC_000913.3 BLAST swissprot:YQCG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQCG_ECOLI BioCyc EcoCyc:MONOMER0-2882 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2882 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2008.06495.x http://dx.doi.org/10.1111/j.1365-2958.2008.06495.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14487 http://www.ecogene.org/geneInfo.php?eg_id=EG14487 EnsemblBacteria ACO60004 http://www.ensemblgenomes.org/id/ACO60004 EnsemblBacteria ACO60004 http://www.ensemblgenomes.org/id/ACO60004 EnsemblBacteria b4682 http://www.ensemblgenomes.org/id/b4682 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0036460 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036460 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 7751618 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7751618 HOGENOM HOG000009543 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009543&db=HOGENOM6 KEGG_Gene eco:b4682 http://www.genome.jp/dbget-bin/www_bget?eco:b4682 PSORT swissprot:YQCG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQCG_ECOLI PSORT-B swissprot:YQCG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQCG_ECOLI PSORT2 swissprot:YQCG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQCG_ECOLI Phobius swissprot:YQCG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQCG_ECOLI PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19121005 http://www.ncbi.nlm.nih.gov/pubmed/19121005 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001288228 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001288228 RefSeq YP_002791252 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_002791252 STRING 511145.b4682 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4682&targetmode=cogs UniProtKB YQCG_ECOLI http://www.uniprot.org/uniprot/YQCG_ECOLI UniProtKB-AC C1P612 http://www.uniprot.org/uniprot/C1P612 charge swissprot:YQCG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQCG_ECOLI epestfind swissprot:YQCG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQCG_ECOLI garnier swissprot:YQCG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQCG_ECOLI helixturnhelix swissprot:YQCG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQCG_ECOLI hmoment swissprot:YQCG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQCG_ECOLI iep swissprot:YQCG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQCG_ECOLI inforesidue swissprot:YQCG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQCG_ECOLI octanol swissprot:YQCG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQCG_ECOLI pepcoil swissprot:YQCG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQCG_ECOLI pepdigest swissprot:YQCG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQCG_ECOLI pepinfo swissprot:YQCG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQCG_ECOLI pepnet swissprot:YQCG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQCG_ECOLI pepstats swissprot:YQCG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQCG_ECOLI pepwheel swissprot:YQCG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQCG_ECOLI pepwindow swissprot:YQCG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQCG_ECOLI sigcleave swissprot:YQCG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQCG_ECOLI ## Database ID URL or Descriptions # BioGrid 4259404 7 # EcoGene EG11945 nrfB # FUNCTION NRFB_ECOLI Plays a role in nitrite reduction. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0009055 electron carrier activity; IDA:EcoCyc. # GO_function GO:0020037 heme binding; IDA:EcoCyc. # GO_function GO:0042279 nitrite reductase (cytochrome, ammonia-forming) activity; IMP:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006807 nitrogen compound metabolic process; IEA:UniProtKB-UniPathway. # GO_process GO:0019645 anaerobic electron transport chain; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0008150 biological_process # IntAct P0ABL1 3 # InterPro IPR010177 Paired_CXXCH_1 # InterPro IPR011031 Multihaem_cyt # InterPro IPR017564 Cyt_c_NO2Rdtase_pentahaem-su # InterPro IPR023155 Cyt_c-552/4 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko00910 Nitrogen metabolism # Organism NRFB_ECOLI Escherichia coli (strain K12) # PATHWAY NRFB_ECOLI Energy metabolism; nitrogen metabolism. # PATRIC 32123691 VBIEscCol129921_4194 # PDB 2OZY X-ray; 1.74 A; A=26-188 # PDB 2P0B X-ray; 1.74 A; A=26-188 # PROSITE PS51008 MULTIHEME_CYTC # PTM NRFB_ECOLI Binds 5 heme groups per subunit. {ECO 0000250}. # Pfam PF09699 Paired_CXXCH_1 # Pfam PF13435 Cytochrome_C554 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NRFB_ECOLI Cytochrome c-type protein NrfB # RefSeq NP_418495 NC_000913.3 # RefSeq WP_001295391 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAC43165.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SUBCELLULAR LOCATION NRFB_ECOLI Periplasm {ECO 0000305}. # SUPFAM SSF48695 SSF48695 # TIGRFAMs TIGR03146 cyt_nit_nrfB # eggNOG ENOG4105JJ8 Bacteria # eggNOG ENOG411128Q LUCA BLAST swissprot:NRFB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NRFB_ECOLI BioCyc ECOL316407:JW4032-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4032-MONOMER BioCyc EcoCyc:CYTOCHROMEC-MONOMER http://biocyc.org/getid?id=EcoCyc:CYTOCHROMEC-MONOMER BioCyc MetaCyc:CYTOCHROMEC-MONOMER http://biocyc.org/getid?id=MetaCyc:CYTOCHROMEC-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1111/j.1365-2958.1994.tb01004.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb01004.x DOI 10.1111/j.1574-6968.1994.tb06872.x http://dx.doi.org/10.1111/j.1574-6968.1994.tb06872.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X72298 http://www.ebi.ac.uk/ena/data/view/X72298 EchoBASE EB1888 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1888 EcoGene EG11945 http://www.ecogene.org/geneInfo.php?eg_id=EG11945 EnsemblBacteria AAC77041 http://www.ensemblgenomes.org/id/AAC77041 EnsemblBacteria AAC77041 http://www.ensemblgenomes.org/id/AAC77041 EnsemblBacteria BAE78073 http://www.ensemblgenomes.org/id/BAE78073 EnsemblBacteria BAE78073 http://www.ensemblgenomes.org/id/BAE78073 EnsemblBacteria BAE78073 http://www.ensemblgenomes.org/id/BAE78073 EnsemblBacteria b4071 http://www.ensemblgenomes.org/id/b4071 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0020037 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0020037 GO_function GO:0042279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042279 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006807 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006807 GO_process GO:0019645 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019645 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 948573 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948573 HOGENOM HOG000278525 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278525&db=HOGENOM6 InParanoid P0ABL1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABL1 IntAct P0ABL1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABL1* InterPro IPR010177 http://www.ebi.ac.uk/interpro/entry/IPR010177 InterPro IPR011031 http://www.ebi.ac.uk/interpro/entry/IPR011031 InterPro IPR017564 http://www.ebi.ac.uk/interpro/entry/IPR017564 InterPro IPR023155 http://www.ebi.ac.uk/interpro/entry/IPR023155 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW4032 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4032 KEGG_Gene eco:b4071 http://www.genome.jp/dbget-bin/www_bget?eco:b4071 KEGG_Orthology KO:K04013 http://www.genome.jp/dbget-bin/www_bget?KO:K04013 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 OMA DHREGAP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DHREGAP PDB 2OZY http://www.ebi.ac.uk/pdbe-srv/view/entry/2OZY PDB 2P0B http://www.ebi.ac.uk/pdbe-srv/view/entry/2P0B PDBsum 2OZY http://www.ebi.ac.uk/pdbsum/2OZY PDBsum 2P0B http://www.ebi.ac.uk/pdbsum/2P0B PROSITE PS51008 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51008 PSORT swissprot:NRFB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NRFB_ECOLI PSORT-B swissprot:NRFB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NRFB_ECOLI PSORT2 swissprot:NRFB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NRFB_ECOLI Pfam PF09699 http://pfam.xfam.org/family/PF09699 Pfam PF13435 http://pfam.xfam.org/family/PF13435 Phobius swissprot:NRFB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NRFB_ECOLI PhylomeDB P0ABL1 http://phylomedb.org/?seqid=P0ABL1 ProteinModelPortal P0ABL1 http://www.proteinmodelportal.org/query/uniprot/P0ABL1 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8039676 http://www.ncbi.nlm.nih.gov/pubmed/8039676 PubMed 8057835 http://www.ncbi.nlm.nih.gov/pubmed/8057835 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418495 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418495 RefSeq WP_001295391 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295391 SMR P0ABL1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABL1 STRING 511145.b4071 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4071&targetmode=cogs SUPFAM SSF48695 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48695 TIGRFAMs TIGR03146 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03146 UniProtKB NRFB_ECOLI http://www.uniprot.org/uniprot/NRFB_ECOLI UniProtKB-AC P0ABL1 http://www.uniprot.org/uniprot/P0ABL1 charge swissprot:NRFB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NRFB_ECOLI eggNOG ENOG4105JJ8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105JJ8 eggNOG ENOG411128Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG411128Q epestfind swissprot:NRFB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NRFB_ECOLI garnier swissprot:NRFB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NRFB_ECOLI helixturnhelix swissprot:NRFB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NRFB_ECOLI hmoment swissprot:NRFB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NRFB_ECOLI iep swissprot:NRFB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NRFB_ECOLI inforesidue swissprot:NRFB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NRFB_ECOLI octanol swissprot:NRFB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NRFB_ECOLI pepcoil swissprot:NRFB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NRFB_ECOLI pepdigest swissprot:NRFB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NRFB_ECOLI pepinfo swissprot:NRFB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NRFB_ECOLI pepnet swissprot:NRFB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NRFB_ECOLI pepstats swissprot:NRFB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NRFB_ECOLI pepwheel swissprot:NRFB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NRFB_ECOLI pepwindow swissprot:NRFB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NRFB_ECOLI sigcleave swissprot:NRFB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NRFB_ECOLI ## Database ID URL or Descriptions # AltName CVPA_ECOLI Protein DedE # AltName CVPA_ECOLI Pur regulon 18 kDa protein # BioGrid 4260527 13 # EcoGene EG10169 cvpA # FUNCTION CVPA_ECOLI Required for colicin V production from plasmid IncFI ColV3-K30. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0009403 toxin biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0019748 secondary metabolic process # InterPro IPR003825 Colicin-V_CvpA # Organism CVPA_ECOLI Escherichia coli (strain K12) # PATRIC 32119997 VBIEscCol129921_2408 # PIR A29803 XMECED # Pfam PF02674 Colicin_V # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CVPA_ECOLI Colicin V production protein # RefSeq NP_416816 NC_000913.3 # RefSeq WP_000262111 NZ_LN832404.1 # SUBCELLULAR LOCATION CVPA_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 9.B.160.1.16 the colicin v production (cvpa) family # eggNOG COG1286 LUCA # eggNOG ENOG4105E96 Bacteria BLAST swissprot:CVPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CVPA_ECOLI BioCyc ECOL316407:JW2310-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2310-MONOMER BioCyc EcoCyc:EG10169-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10169-MONOMER COG COG1286 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1286 DIP DIP-9354N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9354N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01666 http://www.ebi.ac.uk/ena/data/view/J01666 EMBL M68934 http://www.ebi.ac.uk/ena/data/view/M68934 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0167 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0167 EcoGene EG10169 http://www.ecogene.org/geneInfo.php?eg_id=EG10169 EnsemblBacteria AAC75373 http://www.ensemblgenomes.org/id/AAC75373 EnsemblBacteria AAC75373 http://www.ensemblgenomes.org/id/AAC75373 EnsemblBacteria BAA16159 http://www.ensemblgenomes.org/id/BAA16159 EnsemblBacteria BAA16159 http://www.ensemblgenomes.org/id/BAA16159 EnsemblBacteria BAA16159 http://www.ensemblgenomes.org/id/BAA16159 EnsemblBacteria b2313 http://www.ensemblgenomes.org/id/b2313 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0009403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009403 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0019748 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019748 GeneID 945055 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945055 HOGENOM HOG000162044 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000162044&db=HOGENOM6 InParanoid P08550 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P08550 IntAct P08550 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P08550* InterPro IPR003825 http://www.ebi.ac.uk/interpro/entry/IPR003825 KEGG_Gene ecj:JW2310 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2310 KEGG_Gene eco:b2313 http://www.genome.jp/dbget-bin/www_bget?eco:b2313 KEGG_Orthology KO:K03558 http://www.genome.jp/dbget-bin/www_bget?KO:K03558 MINT MINT-1289958 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1289958 OMA APNTDWW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=APNTDWW PSORT swissprot:CVPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CVPA_ECOLI PSORT-B swissprot:CVPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CVPA_ECOLI PSORT2 swissprot:CVPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CVPA_ECOLI Pfam PF02674 http://pfam.xfam.org/family/PF02674 Phobius swissprot:CVPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CVPA_ECOLI PhylomeDB P08550 http://phylomedb.org/?seqid=P08550 ProteinModelPortal P08550 http://www.proteinmodelportal.org/query/uniprot/P08550 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2542219 http://www.ncbi.nlm.nih.gov/pubmed/2542219 PubMed 2991286 http://www.ncbi.nlm.nih.gov/pubmed/2991286 PubMed 3040734 http://www.ncbi.nlm.nih.gov/pubmed/3040734 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416816 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416816 RefSeq WP_000262111 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000262111 STRING 511145.b2313 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2313&targetmode=cogs STRING COG1286 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1286&targetmode=cogs TCDB 9.B.160.1.16 http://www.tcdb.org/search/result.php?tc=9.B.160.1.16 UniProtKB CVPA_ECOLI http://www.uniprot.org/uniprot/CVPA_ECOLI UniProtKB-AC P08550 http://www.uniprot.org/uniprot/P08550 charge swissprot:CVPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CVPA_ECOLI eggNOG COG1286 http://eggnogapi.embl.de/nog_data/html/tree/COG1286 eggNOG ENOG4105E96 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E96 epestfind swissprot:CVPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CVPA_ECOLI garnier swissprot:CVPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CVPA_ECOLI helixturnhelix swissprot:CVPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CVPA_ECOLI hmoment swissprot:CVPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CVPA_ECOLI iep swissprot:CVPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CVPA_ECOLI inforesidue swissprot:CVPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CVPA_ECOLI octanol swissprot:CVPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CVPA_ECOLI pepcoil swissprot:CVPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CVPA_ECOLI pepdigest swissprot:CVPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CVPA_ECOLI pepinfo swissprot:CVPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CVPA_ECOLI pepnet swissprot:CVPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CVPA_ECOLI pepstats swissprot:CVPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CVPA_ECOLI pepwheel swissprot:CVPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CVPA_ECOLI pepwindow swissprot:CVPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CVPA_ECOLI sigcleave swissprot:CVPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CVPA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262424 6 # DISRUPTION PHENOTYPE Mutation confers sensitivity to SDS-EDTA and leads to accumulation of phospholipid in the outer leaflet of the outer membrane. {ECO:0000269|PubMed 19383799}. # EcoGene EG12799 mlaD # FUNCTION MLAD_ECOLI Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. {ECO 0000269|PubMed 19383799}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005543 phospholipid binding; IMP:EcoCyc. # GO_function GO:0005548 phospholipid transporter activity; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008289 lipid binding # GOslim_function GO:0043167 ion binding # InterPro IPR003399 Mce/MlaD # InterPro IPR030970 ABC_MlaD # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00210 Putative ABC transport system # KEGG_Brite ko02000 Transporters # Organism MLAD_ECOLI Escherichia coli (strain K12) # PATRIC 32121806 VBIEscCol129921_3287 # PIR C65110 C65110 # Pfam PF02470 MlaD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Probable phospholipid ABC transporter-binding protein MlaD {ECO 0000305} # RefSeq NP_417660 NC_000913.3 # RefSeq WP_001296448 NZ_LN832404.1 # SIMILARITY Belongs to the MlaD family. {ECO 0000305}. # SUBCELLULAR LOCATION MLAD_ECOLI Cell inner membrane {ECO 0000305|PubMed 19383799}; Single-pass type II membrane protein {ECO 0000305|PubMed 19383799}; Periplasmic side {ECO 0000305|PubMed 19383799}. # SUBUNIT The complex is composed of two ATP-binding proteins (MlaF), two transmembrane proteins (MlaE), two cytoplasmic solute- binding proteins (MlaB) and a periplamic solute-binding protein (MlaD). {ECO:0000305|PubMed 19383799}. # TCDB 3.A.1.27 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR04430 OM_asym_MlaD # eggNOG COG1463 LUCA # eggNOG ENOG4107PE3 Bacteria BLAST swissprot:MLAD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MLAD_ECOLI BioCyc ECOL316407:JW3160-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3160-MONOMER BioCyc EcoCyc:EG12799-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12799-MONOMER COG COG1463 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1463 DIP DIP-12906N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12906N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0903229106 http://dx.doi.org/10.1073/pnas.0903229106 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2651 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2651 EcoGene EG12799 http://www.ecogene.org/geneInfo.php?eg_id=EG12799 EnsemblBacteria AAC76225 http://www.ensemblgenomes.org/id/AAC76225 EnsemblBacteria AAC76225 http://www.ensemblgenomes.org/id/AAC76225 EnsemblBacteria BAE77237 http://www.ensemblgenomes.org/id/BAE77237 EnsemblBacteria BAE77237 http://www.ensemblgenomes.org/id/BAE77237 EnsemblBacteria BAE77237 http://www.ensemblgenomes.org/id/BAE77237 EnsemblBacteria b3193 http://www.ensemblgenomes.org/id/b3193 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005543 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005543 GO_function GO:0005548 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005548 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GeneID 947712 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947712 HOGENOM HOG000255143 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000255143&db=HOGENOM6 InParanoid P64604 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P64604 IntAct P64604 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P64604* InterPro IPR003399 http://www.ebi.ac.uk/interpro/entry/IPR003399 InterPro IPR030970 http://www.ebi.ac.uk/interpro/entry/IPR030970 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3160 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3160 KEGG_Gene eco:b3193 http://www.genome.jp/dbget-bin/www_bget?eco:b3193 KEGG_Orthology KO:K02067 http://www.genome.jp/dbget-bin/www_bget?KO:K02067 MINT MINT-6478352 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-6478352 OMA EQYIGLE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EQYIGLE PSORT swissprot:MLAD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MLAD_ECOLI PSORT-B swissprot:MLAD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MLAD_ECOLI PSORT2 swissprot:MLAD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MLAD_ECOLI Pfam PF02470 http://pfam.xfam.org/family/PF02470 Phobius swissprot:MLAD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MLAD_ECOLI PhylomeDB P64604 http://phylomedb.org/?seqid=P64604 ProteinModelPortal P64604 http://www.proteinmodelportal.org/query/uniprot/P64604 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19383799 http://www.ncbi.nlm.nih.gov/pubmed/19383799 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417660 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417660 RefSeq WP_001296448 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001296448 STRING 511145.b3193 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3193&targetmode=cogs STRING COG1463 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1463&targetmode=cogs TCDB 3.A.1.27 http://www.tcdb.org/search/result.php?tc=3.A.1.27 TIGRFAMs TIGR04430 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR04430 UniProtKB MLAD_ECOLI http://www.uniprot.org/uniprot/MLAD_ECOLI UniProtKB-AC P64604 http://www.uniprot.org/uniprot/P64604 charge swissprot:MLAD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MLAD_ECOLI eggNOG COG1463 http://eggnogapi.embl.de/nog_data/html/tree/COG1463 eggNOG ENOG4107PE3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107PE3 epestfind swissprot:MLAD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MLAD_ECOLI garnier swissprot:MLAD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MLAD_ECOLI helixturnhelix swissprot:MLAD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MLAD_ECOLI hmoment swissprot:MLAD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MLAD_ECOLI iep swissprot:MLAD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MLAD_ECOLI inforesidue swissprot:MLAD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MLAD_ECOLI octanol swissprot:MLAD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MLAD_ECOLI pepcoil swissprot:MLAD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MLAD_ECOLI pepdigest swissprot:MLAD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MLAD_ECOLI pepinfo swissprot:MLAD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MLAD_ECOLI pepnet swissprot:MLAD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MLAD_ECOLI pepstats swissprot:MLAD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MLAD_ECOLI pepwheel swissprot:MLAD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MLAD_ECOLI pepwindow swissprot:MLAD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MLAD_ECOLI sigcleave swissprot:MLAD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MLAD_ECOLI ## Database ID URL or Descriptions # EcoGene EG14280 yaiZ # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR020490 Uncharacterised_YaiZ # Organism YAIZ_ECOLI Escherichia coli (strain K12) # PATRIC 32115901 VBIEscCol129921_0392 # PIR D64766 D64766 # Pfam PF10953 DUF2754 # ProDom PD073772 Uncharacterised_YaiZ # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAIZ_ECOLI Uncharacterized protein YaiZ # RefSeq NP_414914 NC_000913.3 # RefSeq WP_001295334 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18103.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SUBCELLULAR LOCATION YAIZ_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # eggNOG ENOG4105UNH Bacteria # eggNOG ENOG4111XE9 LUCA BLAST swissprot:YAIZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAIZ_ECOLI BioCyc ECOL316407:JW5053-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5053-MONOMER BioCyc EcoCyc:G6229-MONOMER http://biocyc.org/getid?id=EcoCyc:G6229-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB4028 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4028 EcoGene EG14280 http://www.ecogene.org/geneInfo.php?eg_id=EG14280 EnsemblBacteria AAC73483 http://www.ensemblgenomes.org/id/AAC73483 EnsemblBacteria AAC73483 http://www.ensemblgenomes.org/id/AAC73483 EnsemblBacteria BAE76161 http://www.ensemblgenomes.org/id/BAE76161 EnsemblBacteria BAE76161 http://www.ensemblgenomes.org/id/BAE76161 EnsemblBacteria BAE76161 http://www.ensemblgenomes.org/id/BAE76161 EnsemblBacteria b0380 http://www.ensemblgenomes.org/id/b0380 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 947355 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947355 HOGENOM HOG000117490 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117490&db=HOGENOM6 InterPro IPR020490 http://www.ebi.ac.uk/interpro/entry/IPR020490 KEGG_Gene ecj:JW5053 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5053 KEGG_Gene eco:b0380 http://www.genome.jp/dbget-bin/www_bget?eco:b0380 OMA RCELQNG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RCELQNG PSORT swissprot:YAIZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAIZ_ECOLI PSORT-B swissprot:YAIZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAIZ_ECOLI PSORT2 swissprot:YAIZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAIZ_ECOLI Pfam PF10953 http://pfam.xfam.org/family/PF10953 Phobius swissprot:YAIZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAIZ_ECOLI ProteinModelPortal P0AAQ0 http://www.proteinmodelportal.org/query/uniprot/P0AAQ0 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414914 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414914 RefSeq WP_001295334 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295334 STRING 511145.b0380 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0380&targetmode=cogs UniProtKB YAIZ_ECOLI http://www.uniprot.org/uniprot/YAIZ_ECOLI UniProtKB-AC P0AAQ0 http://www.uniprot.org/uniprot/P0AAQ0 charge swissprot:YAIZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAIZ_ECOLI eggNOG ENOG4105UNH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105UNH eggNOG ENOG4111XE9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111XE9 epestfind swissprot:YAIZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAIZ_ECOLI garnier swissprot:YAIZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAIZ_ECOLI helixturnhelix swissprot:YAIZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAIZ_ECOLI hmoment swissprot:YAIZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAIZ_ECOLI iep swissprot:YAIZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAIZ_ECOLI inforesidue swissprot:YAIZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAIZ_ECOLI octanol swissprot:YAIZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAIZ_ECOLI pepcoil swissprot:YAIZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAIZ_ECOLI pepdigest swissprot:YAIZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAIZ_ECOLI pepinfo swissprot:YAIZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAIZ_ECOLI pepnet swissprot:YAIZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAIZ_ECOLI pepstats swissprot:YAIZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAIZ_ECOLI pepwheel swissprot:YAIZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAIZ_ECOLI pepwindow swissprot:YAIZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAIZ_ECOLI sigcleave swissprot:YAIZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAIZ_ECOLI ## Database ID URL or Descriptions # BioGrid 4259966 8 # EcoGene EG11581 ybiC # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0016491 oxidoreductase activity; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # InterPro IPR003767 Malate/L-lactate_DH # KEGG_Brite ko01000 Enzymes # Organism YBIC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11091 PTHR11091 # PATRIC 32116805 VBIEscCol129921_0828 # PDB 2G8Y X-ray; 2.15 A; A/B=1-361 # PIR A64817 A64817 # Pfam PF02615 Ldh_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBIC_ECOLI Uncharacterized oxidoreductase YbiC # RefSeq NP_415322 NC_000913.3 # RefSeq WP_000443530 NZ_LN832404.1 # SIMILARITY Belongs to the LDH2/MDH2 oxidoreductase family. {ECO 0000305}. # SUBCELLULAR LOCATION YBIC_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF89733 SSF89733 # eggNOG COG2055 LUCA # eggNOG ENOG4105DG4 Bacteria BLAST swissprot:YBIC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBIC_ECOLI BioCyc ECOL316407:JW0786-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0786-MONOMER BioCyc EcoCyc:EG11581-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11581-MONOMER COG COG2055 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2055 DIP DIP-11426N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11426N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1266/jjg.69.1 http://dx.doi.org/10.1266/jjg.69.1 EC_number EC:1.1.1.- http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L02123 http://www.ebi.ac.uk/ena/data/view/L02123 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.1.1.- http://enzyme.expasy.org/EC/1.1.1.- EchoBASE EB1541 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1541 EcoGene EG11581 http://www.ecogene.org/geneInfo.php?eg_id=EG11581 EnsemblBacteria AAC73888 http://www.ensemblgenomes.org/id/AAC73888 EnsemblBacteria AAC73888 http://www.ensemblgenomes.org/id/AAC73888 EnsemblBacteria BAA35467 http://www.ensemblgenomes.org/id/BAA35467 EnsemblBacteria BAA35467 http://www.ensemblgenomes.org/id/BAA35467 EnsemblBacteria BAA35467 http://www.ensemblgenomes.org/id/BAA35467 EnsemblBacteria b0801 http://www.ensemblgenomes.org/id/b0801 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GeneID 945412 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945412 HOGENOM HOG000173271 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000173271&db=HOGENOM6 InParanoid P30178 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30178 IntEnz 1.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1 InterPro IPR003767 http://www.ebi.ac.uk/interpro/entry/IPR003767 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0786 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0786 KEGG_Gene eco:b0801 http://www.genome.jp/dbget-bin/www_bget?eco:b0801 KEGG_Orthology KO:K13574 http://www.genome.jp/dbget-bin/www_bget?KO:K13574 OMA ANGMFSI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ANGMFSI PANTHER PTHR11091 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11091 PDB 2G8Y http://www.ebi.ac.uk/pdbe-srv/view/entry/2G8Y PDBsum 2G8Y http://www.ebi.ac.uk/pdbsum/2G8Y PSORT swissprot:YBIC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBIC_ECOLI PSORT-B swissprot:YBIC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBIC_ECOLI PSORT2 swissprot:YBIC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBIC_ECOLI Pfam PF02615 http://pfam.xfam.org/family/PF02615 Phobius swissprot:YBIC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBIC_ECOLI PhylomeDB P30178 http://phylomedb.org/?seqid=P30178 ProteinModelPortal P30178 http://www.proteinmodelportal.org/query/uniprot/P30178 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8037924 http://www.ncbi.nlm.nih.gov/pubmed/8037924 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415322 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415322 RefSeq WP_000443530 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000443530 SMR P30178 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P30178 STRING 511145.b0801 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0801&targetmode=cogs STRING COG2055 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2055&targetmode=cogs SUPFAM SSF89733 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF89733 UniProtKB YBIC_ECOLI http://www.uniprot.org/uniprot/YBIC_ECOLI UniProtKB-AC P30178 http://www.uniprot.org/uniprot/P30178 charge swissprot:YBIC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBIC_ECOLI eggNOG COG2055 http://eggnogapi.embl.de/nog_data/html/tree/COG2055 eggNOG ENOG4105DG4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DG4 epestfind swissprot:YBIC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBIC_ECOLI garnier swissprot:YBIC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBIC_ECOLI helixturnhelix swissprot:YBIC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBIC_ECOLI hmoment swissprot:YBIC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBIC_ECOLI iep swissprot:YBIC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBIC_ECOLI inforesidue swissprot:YBIC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBIC_ECOLI octanol swissprot:YBIC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBIC_ECOLI pepcoil swissprot:YBIC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBIC_ECOLI pepdigest swissprot:YBIC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBIC_ECOLI pepinfo swissprot:YBIC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBIC_ECOLI pepnet swissprot:YBIC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBIC_ECOLI pepstats swissprot:YBIC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBIC_ECOLI pepwheel swissprot:YBIC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBIC_ECOLI pepwindow swissprot:YBIC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBIC_ECOLI sigcleave swissprot:YBIC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBIC_ECOLI ## Database ID URL or Descriptions # AltName SPPA_ECOLI Endopeptidase IV # AltName SPPA_ECOLI Protease IV # AltName SPPA_ECOLI Signal peptide peptidase # BioGrid 4259140 4 # CDD cd07019 S49_SppA_1 # DISRUPTION PHENOTYPE No effect on processing of liberated signal peptides in vivo. {ECO:0000269|PubMed 21810987}. # DOMAIN SPPA_ECOLI A tandem duplication in the protein fold creates an intact active site between the repeated domains of each monomer. # ENZYME REGULATION Inhibited by serine hydrolase inhibitor FP- biotin and by antipain. {ECO:0000269|PubMed 3522590}. # EcoGene EG10968 sppA # FUNCTION SPPA_ECOLI Digests cleaved signal peptides in vitro, its in vivo function is unknown. This activity is necessary to maintain proper secretion of mature proteins across the membrane. {ECO 0000269|PubMed 18164727, ECO 0000269|PubMed 18476724, ECO 0000269|PubMed 21810987, ECO 0000269|PubMed 3522590}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0004175 endopeptidase activity; IDA:EcoCyc. # GO_function GO:0008236 serine-type peptidase activity; IEA:UniProtKB-KW. # GO_process GO:0006465 signal peptide processing; IMP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0008233 peptidase activity # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0051604 protein maturation # Gene3D 3.90.226.10 -; 4. # InterPro IPR002142 Peptidase_S49 # InterPro IPR004634 Pept_S49_pIV # InterPro IPR004635 Pept_S49_SppA # InterPro IPR029045 ClpP/crotonase-like_dom # InterPro IPR033854 S49_SppA_1 # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # Organism SPPA_ECOLI Escherichia coli (strain K12) # PATRIC 32118843 VBIEscCol129921_1839 # PDB 3BEZ X-ray; 2.76 A; A/B/C/D=47-618 # PDB 3BF0 X-ray; 2.55 A; A/B/C/D=47-618 # PIR F64936 PRECT4 # PIR I81191 I81191 # PIRSF PIRSF001217 Protease_4_SppA # Pfam PF01343 Peptidase_S49; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SPPA_ECOLI Protease 4 # RefSeq NP_416280 NC_000913.3 # RefSeq WP_001259810 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase S49 family. {ECO 0000305}. # SUBCELLULAR LOCATION SPPA_ECOLI Cell inner membrane {ECO 0000269|PubMed 18476724, ECO 0000269|PubMed 3522590}; Single- pass membrane protein {ECO 0000269|PubMed 18476724, ECO 0000269|PubMed 3522590}. # SUBUNIT SPPA_ECOLI Homotetramer. {ECO 0000269|PubMed 18164727, ECO 0000269|PubMed 3522590}. # SUPFAM SSF52096 SSF52096; 4 # TIGRFAMs TIGR00705 SppA_67K # TIGRFAMs TIGR00706 SppA_dom # eggNOG COG0616 LUCA # eggNOG ENOG4105D07 Bacteria BLAST swissprot:SPPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SPPA_ECOLI BioCyc ECOL316407:JW1755-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1755-MONOMER BioCyc EcoCyc:EG10968-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10968-MONOMER BioCyc MetaCyc:EG10968-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10968-MONOMER COG COG0616 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0616 DOI 10.1016/j.jmb.2007.11.080 http://dx.doi.org/10.1016/j.jmb.2007.11.080 DOI 10.1021/bi800657p http://dx.doi.org/10.1021/bi800657p DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.1108376108 http://dx.doi.org/10.1073/pnas.1108376108 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1126/science.7973728 http://dx.doi.org/10.1126/science.7973728 EC_number EC:3.4.21.- http://www.genome.jp/dbget-bin/www_bget?EC:3.4.21.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M13359 http://www.ebi.ac.uk/ena/data/view/M13359 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U13772 http://www.ebi.ac.uk/ena/data/view/U13772 EMBL U13773 http://www.ebi.ac.uk/ena/data/view/U13773 EMBL U13774 http://www.ebi.ac.uk/ena/data/view/U13774 EMBL U13775 http://www.ebi.ac.uk/ena/data/view/U13775 EMBL U13776 http://www.ebi.ac.uk/ena/data/view/U13776 EMBL U13777 http://www.ebi.ac.uk/ena/data/view/U13777 EMBL U13778 http://www.ebi.ac.uk/ena/data/view/U13778 EMBL U13779 http://www.ebi.ac.uk/ena/data/view/U13779 EMBL U13780 http://www.ebi.ac.uk/ena/data/view/U13780 EMBL U13782 http://www.ebi.ac.uk/ena/data/view/U13782 EMBL U13833 http://www.ebi.ac.uk/ena/data/view/U13833 EMBL U13834 http://www.ebi.ac.uk/ena/data/view/U13834 ENZYME 3.4.21.- http://enzyme.expasy.org/EC/3.4.21.- EchoBASE EB0961 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0961 EcoGene EG10968 http://www.ecogene.org/geneInfo.php?eg_id=EG10968 EnsemblBacteria AAC74836 http://www.ensemblgenomes.org/id/AAC74836 EnsemblBacteria AAC74836 http://www.ensemblgenomes.org/id/AAC74836 EnsemblBacteria BAA15557 http://www.ensemblgenomes.org/id/BAA15557 EnsemblBacteria BAA15557 http://www.ensemblgenomes.org/id/BAA15557 EnsemblBacteria BAA15557 http://www.ensemblgenomes.org/id/BAA15557 EnsemblBacteria b1766 http://www.ensemblgenomes.org/id/b1766 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0004175 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004175 GO_function GO:0008236 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008236 GO_process GO:0006465 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006465 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 Gene3D 3.90.226.10 http://www.cathdb.info/version/latest/superfamily/3.90.226.10 GeneID 946281 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946281 InParanoid P08395 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P08395 IntAct P08395 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P08395* IntEnz 3.4.21 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.21 InterPro IPR002142 http://www.ebi.ac.uk/interpro/entry/IPR002142 InterPro IPR004634 http://www.ebi.ac.uk/interpro/entry/IPR004634 InterPro IPR004635 http://www.ebi.ac.uk/interpro/entry/IPR004635 InterPro IPR029045 http://www.ebi.ac.uk/interpro/entry/IPR029045 InterPro IPR033854 http://www.ebi.ac.uk/interpro/entry/IPR033854 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW1755 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1755 KEGG_Gene eco:b1766 http://www.genome.jp/dbget-bin/www_bget?eco:b1766 KEGG_Orthology KO:K04773 http://www.genome.jp/dbget-bin/www_bget?KO:K04773 OMA WSKADNN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WSKADNN PDB 3BEZ http://www.ebi.ac.uk/pdbe-srv/view/entry/3BEZ PDB 3BF0 http://www.ebi.ac.uk/pdbe-srv/view/entry/3BF0 PDBsum 3BEZ http://www.ebi.ac.uk/pdbsum/3BEZ PDBsum 3BF0 http://www.ebi.ac.uk/pdbsum/3BF0 PSORT swissprot:SPPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SPPA_ECOLI PSORT-B swissprot:SPPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SPPA_ECOLI PSORT2 swissprot:SPPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SPPA_ECOLI Pfam PF01343 http://pfam.xfam.org/family/PF01343 Phobius swissprot:SPPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SPPA_ECOLI PhylomeDB P08395 http://phylomedb.org/?seqid=P08395 ProteinModelPortal P08395 http://www.proteinmodelportal.org/query/uniprot/P08395 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18164727 http://www.ncbi.nlm.nih.gov/pubmed/18164727 PubMed 18476724 http://www.ncbi.nlm.nih.gov/pubmed/18476724 PubMed 21810987 http://www.ncbi.nlm.nih.gov/pubmed/21810987 PubMed 3522590 http://www.ncbi.nlm.nih.gov/pubmed/3522590 PubMed 7973728 http://www.ncbi.nlm.nih.gov/pubmed/7973728 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416280 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416280 RefSeq WP_001259810 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001259810 SMR P08395 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P08395 STRING 511145.b1766 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1766&targetmode=cogs STRING COG0616 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0616&targetmode=cogs SUPFAM SSF52096 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52096 TIGRFAMs TIGR00705 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00705 TIGRFAMs TIGR00706 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00706 UniProtKB SPPA_ECOLI http://www.uniprot.org/uniprot/SPPA_ECOLI UniProtKB-AC P08395 http://www.uniprot.org/uniprot/P08395 charge swissprot:SPPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SPPA_ECOLI eggNOG COG0616 http://eggnogapi.embl.de/nog_data/html/tree/COG0616 eggNOG ENOG4105D07 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D07 epestfind swissprot:SPPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SPPA_ECOLI garnier swissprot:SPPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SPPA_ECOLI helixturnhelix swissprot:SPPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SPPA_ECOLI hmoment swissprot:SPPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SPPA_ECOLI iep swissprot:SPPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SPPA_ECOLI inforesidue swissprot:SPPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SPPA_ECOLI octanol swissprot:SPPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SPPA_ECOLI pepcoil swissprot:SPPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SPPA_ECOLI pepdigest swissprot:SPPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SPPA_ECOLI pepinfo swissprot:SPPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SPPA_ECOLI pepnet swissprot:SPPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SPPA_ECOLI pepstats swissprot:SPPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SPPA_ECOLI pepwheel swissprot:SPPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SPPA_ECOLI pepwindow swissprot:SPPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SPPA_ECOLI sigcleave swissprot:SPPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SPPA_ECOLI ## Database ID URL or Descriptions # AltName Kdo(2)-lipid A phosphotransferase {ECO 0000305} # AltName LPXT_ECOLI Undecaprenyl pyrophosphate lipid A 1-phosphate phosphotransferase {ECO 0000255|HAMAP-Rule MF_01945, ECO 0000305} # BIOPHYSICOCHEMICAL PROPERTIES pH dependence: Optimum pH is 7.0. Significant activity is observed from pH 5.5 to pH 7.5. {ECO 0000269|PubMed:18047581}; # BioGrid 4260460 4 # CATALYTIC ACTIVITY LPXT_ECOLI Ditrans-octacis-undecaprenyl diphosphate + alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A = ditrans-octacis- undecaprenyl phosphate + alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)- lipid A 1-diphosphate. {ECO 0000255|HAMAP-Rule MF_01945, ECO 0000269|PubMed 18047581}. # DISRUPTION PHENOTYPE Deletion of the gene results in the production of LPS containing only the bis-phosphorylated lipid A species. {ECO:0000269|PubMed 18047581}. # ENZYME REGULATION Inhibited by BasR. This regulation does not occur at the level of transcription, but rather following the assembly of LpxT into the inner membrane. {ECO:0000269|PubMed 20384697}. # EcoGene EG14075 lpxT # FUNCTION LPXT_ECOLI Involved in the modification of the lipid A domain of lipopolysaccharides (LPS). Transfers a phosphate group from undecaprenyl pyrophosphate (C55-PP) to lipid A to form lipid A 1- diphosphate. Contributes to the recycling of undecaprenyl phosphate (C55-P) (PubMed 18047581). In vitro, has low undecaprenyl-diphosphate phosphatase activity (PubMed 17660416). {ECO 0000269|PubMed 17660416, ECO 0000269|PubMed 18047581}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IEA:UniProtKB-HAMAP. # GO_function GO:0016776 phosphotransferase activity, phosphate group as acceptor; IDA:EcoCyc. # GO_function GO:0050380 undecaprenyl-diphosphatase activity; IDA:EcoCyc. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0009245 lipid A biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0043165 Gram-negative-bacterium-type cell outer membrane assembly; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0061024 membrane organization # Gene3D 1.20.144.10 -; 1. # HAMAP MF_01945 Lipid_A_LpxT # InterPro IPR000326 P_Acid_Pase_2/haloperoxidase # InterPro IPR032908 LpxT # MISCELLANEOUS In E.coli, lipid A contains typically a monophosphate unit at positions 1 and 4' (bis-phosphorylated lipid A). However, one-third of the lipid A contains an unsubstituted diphosphate unit at position 1 (lipid A 1-diphosphate). {ECO:0000305|PubMed 18047581}. # Organism LPXT_ECOLI Escherichia coli (strain K12) # PATHWAY LPXT_ECOLI Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. {ECO 0000255|HAMAP-Rule MF_01945, ECO 0000269|PubMed 18047581}. # PATRIC 32119703 VBIEscCol129921_2262 # Pfam PF01569 PAP2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Lipid A 1-diphosphate synthase {ECO:0000255|HAMAP-Rule MF_01945, ECO:0000305} # RefSeq NP_416679 NC_000913.3 # RefSeq WP_000594599 NZ_LN832404.1 # SIMILARITY Belongs to the LpxT phosphotransferase family. {ECO:0000255|HAMAP-Rule MF_01945, ECO:0000305}. # SMART SM00014 acidPPc # SUBCELLULAR LOCATION LPXT_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01945, ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 17660416}; Multi-pass membrane protein {ECO 0000255|HAMAP-Rule MF_01945, ECO 0000269|PubMed 17660416}. Note=Transferase activity takes place on the periplamic side of the inner membrane. {ECO 0000255|HAMAP-Rule MF_01945, ECO 0000269|PubMed 18047581}. # SUPFAM SSF48317 SSF48317 # eggNOG COG0671 LUCA # eggNOG ENOG41076MN Bacteria BLAST swissprot:LPXT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LPXT_ECOLI BioCyc ECOL316407:JW2162-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2162-MONOMER BioCyc EcoCyc:G7146-MONOMER http://biocyc.org/getid?id=EcoCyc:G7146-MONOMER BioCyc MetaCyc:G7146-MONOMER http://biocyc.org/getid?id=MetaCyc:G7146-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1099/mic.0.2007/006312-0 http://dx.doi.org/10.1099/mic.0.2007/006312-0 DOI 10.1111/j.1365-2958.2007.06044.x http://dx.doi.org/10.1111/j.1365-2958.2007.06044.x DOI 10.1111/j.1365-2958.2010.07150.x http://dx.doi.org/10.1111/j.1365-2958.2010.07150.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.4.29 {ECO:0000255|HAMAP-Rule:MF_01945, ECO:0000269|PubMed:18047581} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.4.29 {ECO:0000255|HAMAP-Rule:MF_01945, ECO:0000269|PubMed:18047581} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.4.29 {ECO:0000255|HAMAP-Rule:MF_01945, ECO:0000269|PubMed:18047581} http://enzyme.expasy.org/EC/2.7.4.29 {ECO:0000255|HAMAP-Rule:MF_01945, ECO:0000269|PubMed:18047581} EchoBASE EB3828 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3828 EcoGene EG14075 http://www.ecogene.org/geneInfo.php?eg_id=EG14075 EnsemblBacteria AAC75235 http://www.ensemblgenomes.org/id/AAC75235 EnsemblBacteria AAC75235 http://www.ensemblgenomes.org/id/AAC75235 EnsemblBacteria BAE76645 http://www.ensemblgenomes.org/id/BAE76645 EnsemblBacteria BAE76645 http://www.ensemblgenomes.org/id/BAE76645 EnsemblBacteria BAE76645 http://www.ensemblgenomes.org/id/BAE76645 EnsemblBacteria b2174 http://www.ensemblgenomes.org/id/b2174 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0016776 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016776 GO_function GO:0050380 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050380 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GO_process GO:0009245 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009245 GO_process GO:0043165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043165 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0061024 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024 Gene3D 1.20.144.10 http://www.cathdb.info/version/latest/superfamily/1.20.144.10 GeneID 946693 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946693 HAMAP MF_01945 http://hamap.expasy.org/unirule/MF_01945 HOGENOM HOG000282674 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000282674&db=HOGENOM6 InParanoid P76445 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76445 IntEnz 2.7.4.29 {ECO:0000255|HAMAP-Rule:MF_01945, ECO:0000269|PubMed:18047581} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.4.29 {ECO:0000255|HAMAP-Rule:MF_01945, ECO:0000269|PubMed:18047581} InterPro IPR000326 http://www.ebi.ac.uk/interpro/entry/IPR000326 InterPro IPR032908 http://www.ebi.ac.uk/interpro/entry/IPR032908 KEGG_Gene ecj:JW2162 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2162 KEGG_Gene eco:b2174 http://www.genome.jp/dbget-bin/www_bget?eco:b2174 OMA RSFPGDH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RSFPGDH PSORT swissprot:LPXT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LPXT_ECOLI PSORT-B swissprot:LPXT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LPXT_ECOLI PSORT2 swissprot:LPXT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LPXT_ECOLI Pfam PF01569 http://pfam.xfam.org/family/PF01569 Phobius swissprot:LPXT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LPXT_ECOLI PhylomeDB P76445 http://phylomedb.org/?seqid=P76445 ProteinModelPortal P76445 http://www.proteinmodelportal.org/query/uniprot/P76445 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17660416 http://www.ncbi.nlm.nih.gov/pubmed/17660416 PubMed 18047581 http://www.ncbi.nlm.nih.gov/pubmed/18047581 PubMed 20384697 http://www.ncbi.nlm.nih.gov/pubmed/20384697 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416679 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416679 RefSeq WP_000594599 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000594599 SMART SM00014 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00014 STRING 511145.b2174 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2174&targetmode=cogs SUPFAM SSF48317 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48317 UniProtKB LPXT_ECOLI http://www.uniprot.org/uniprot/LPXT_ECOLI UniProtKB-AC P76445 http://www.uniprot.org/uniprot/P76445 charge swissprot:LPXT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LPXT_ECOLI eggNOG COG0671 http://eggnogapi.embl.de/nog_data/html/tree/COG0671 eggNOG ENOG41076MN http://eggnogapi.embl.de/nog_data/html/tree/ENOG41076MN epestfind swissprot:LPXT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LPXT_ECOLI garnier swissprot:LPXT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LPXT_ECOLI helixturnhelix swissprot:LPXT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LPXT_ECOLI hmoment swissprot:LPXT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LPXT_ECOLI iep swissprot:LPXT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LPXT_ECOLI inforesidue swissprot:LPXT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LPXT_ECOLI octanol swissprot:LPXT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LPXT_ECOLI pepcoil swissprot:LPXT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LPXT_ECOLI pepdigest swissprot:LPXT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LPXT_ECOLI pepinfo swissprot:LPXT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LPXT_ECOLI pepnet swissprot:LPXT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LPXT_ECOLI pepstats swissprot:LPXT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LPXT_ECOLI pepwheel swissprot:LPXT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LPXT_ECOLI pepwindow swissprot:LPXT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LPXT_ECOLI sigcleave swissprot:LPXT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LPXT_ECOLI ## Database ID URL or Descriptions # AltName Multidrug transporter MdtB {ECO:0000255|HAMAP-Rule MF_01423} # BioGrid 4262010 440 # EcoGene EG14057 mdtB # FUNCTION MDTB_ECOLI The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate. MdtABC requires TolC for its function. {ECO 0000255|HAMAP-Rule MF_01423, ECO 0000269|PubMed 12107133, ECO 0000269|PubMed 12107134}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_function GO:0005215 transporter activity; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # Gene3D 3.30.2090.10 -; 2. # HAMAP MF_01423 MdtB # INDUCTION MDTB_ECOLI The mdtABC operon is transcriptionally activated by BaeR. {ECO 0000255|HAMAP-Rule MF_01423, ECO 0000269|PubMed 12107133, ECO 0000269|PubMed 12107134}. # INTERACTION MDTB_ECOLI P76399 mdtC; NbExp=3; IntAct=EBI-561416, EBI-1116694; # IntAct P76398 3 # InterPro IPR001036 Acrflvin-R # InterPro IPR022831 Multidrug-R_MdtB # InterPro IPR027463 AcrB_DN_DC_subdom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko02020 Two-component system # Organism MDTB_ECOLI Escherichia coli (strain K12) # PATRIC 32119483 VBIEscCol129921_2152 # PIR B64974 B64974 # PRINTS PR00702 ACRIFLAVINRP # Pfam PF00873 ACR_tran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Multidrug resistance protein MdtB {ECO:0000255|HAMAP-Rule MF_01423} # RefSeq NP_416579 NC_000913.3 # RefSeq WP_001197875 NZ_LN832404.1 # SIMILARITY Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtB subfamily. {ECO:0000255|HAMAP- Rule MF_01423}. # SUBCELLULAR LOCATION MDTB_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01423}; Multi-pass membrane protein {ECO 0000255|HAMAP- Rule MF_01423}. # SUBUNIT MDTB_ECOLI Part of a tripartite efflux system composed of MdtA, MdtB and MdtC. MdtB forms a heteromultimer with MdtC. # SUPFAM SSF82714 SSF82714; 2 # TCDB 2.A.6.2.12 the resistance-nodulation-cell division (rnd) superfamily # eggNOG COG0841 LUCA # eggNOG ENOG4105BZS Bacteria BLAST swissprot:MDTB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MDTB_ECOLI BioCyc ECOL316407:JW2060-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2060-MONOMER BioCyc EcoCyc:B2075-MONOMER http://biocyc.org/getid?id=EcoCyc:B2075-MONOMER COG COG0841 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0841 DIP DIP-11884N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11884N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.15.4161-4167.2002 http://dx.doi.org/10.1128/JB.184.15.4161-4167.2002 DOI 10.1128/JB.184.15.4168-4176.2002 http://dx.doi.org/10.1128/JB.184.15.4168-4176.2002 EMBL AB089188 http://www.ebi.ac.uk/ena/data/view/AB089188 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3810 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3810 EcoGene EG14057 http://www.ecogene.org/geneInfo.php?eg_id=EG14057 EnsemblBacteria AAC75136 http://www.ensemblgenomes.org/id/AAC75136 EnsemblBacteria AAC75136 http://www.ensemblgenomes.org/id/AAC75136 EnsemblBacteria BAA15929 http://www.ensemblgenomes.org/id/BAA15929 EnsemblBacteria BAA15929 http://www.ensemblgenomes.org/id/BAA15929 EnsemblBacteria BAA15929 http://www.ensemblgenomes.org/id/BAA15929 EnsemblBacteria b2075 http://www.ensemblgenomes.org/id/b2075 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 Gene3D 3.30.2090.10 http://www.cathdb.info/version/latest/superfamily/3.30.2090.10 GeneID 946606 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946606 HAMAP MF_01423 http://hamap.expasy.org/unirule/MF_01423 HOGENOM HOG000158127 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000158127&db=HOGENOM6 InParanoid P76398 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76398 IntAct P76398 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76398* InterPro IPR001036 http://www.ebi.ac.uk/interpro/entry/IPR001036 InterPro IPR022831 http://www.ebi.ac.uk/interpro/entry/IPR022831 InterPro IPR027463 http://www.ebi.ac.uk/interpro/entry/IPR027463 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW2060 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2060 KEGG_Gene eco:b2075 http://www.genome.jp/dbget-bin/www_bget?eco:b2075 KEGG_Orthology KO:K07788 http://www.genome.jp/dbget-bin/www_bget?KO:K07788 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 MINT MINT-1301811 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1301811 OMA VPMMCAK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VPMMCAK PRINTS PR00702 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00702 PSORT swissprot:MDTB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MDTB_ECOLI PSORT-B swissprot:MDTB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MDTB_ECOLI PSORT2 swissprot:MDTB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MDTB_ECOLI Pfam PF00873 http://pfam.xfam.org/family/PF00873 Phobius swissprot:MDTB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MDTB_ECOLI PhylomeDB P76398 http://phylomedb.org/?seqid=P76398 ProteinModelPortal P76398 http://www.proteinmodelportal.org/query/uniprot/P76398 PubMed 12107133 http://www.ncbi.nlm.nih.gov/pubmed/12107133 PubMed 12107134 http://www.ncbi.nlm.nih.gov/pubmed/12107134 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416579 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416579 RefSeq WP_001197875 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001197875 SMR P76398 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76398 STRING 511145.b2075 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2075&targetmode=cogs STRING COG0841 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0841&targetmode=cogs SUPFAM SSF82714 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF82714 TCDB 2.A.6.2.12 http://www.tcdb.org/search/result.php?tc=2.A.6.2.12 UniProtKB MDTB_ECOLI http://www.uniprot.org/uniprot/MDTB_ECOLI UniProtKB-AC P76398 http://www.uniprot.org/uniprot/P76398 charge swissprot:MDTB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MDTB_ECOLI eggNOG COG0841 http://eggnogapi.embl.de/nog_data/html/tree/COG0841 eggNOG ENOG4105BZS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZS epestfind swissprot:MDTB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MDTB_ECOLI garnier swissprot:MDTB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MDTB_ECOLI helixturnhelix swissprot:MDTB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MDTB_ECOLI hmoment swissprot:MDTB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MDTB_ECOLI iep swissprot:MDTB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MDTB_ECOLI inforesidue swissprot:MDTB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MDTB_ECOLI octanol swissprot:MDTB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MDTB_ECOLI pepcoil swissprot:MDTB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MDTB_ECOLI pepdigest swissprot:MDTB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MDTB_ECOLI pepinfo swissprot:MDTB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MDTB_ECOLI pepnet swissprot:MDTB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MDTB_ECOLI pepstats swissprot:MDTB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MDTB_ECOLI pepwheel swissprot:MDTB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MDTB_ECOLI pepwindow swissprot:MDTB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MDTB_ECOLI sigcleave swissprot:MDTB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MDTB_ECOLI ## Database ID URL or Descriptions # BioGrid 4259641 189 # EcoGene EG10905 rpsF # FUNCTION RS6_ECOLI Binds together with S18 to 16S ribosomal RNA. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0022627 cytosolic small ribosomal subunit; IDA:EcoliWiki. # GO_function GO:0003735 structural constituent of ribosome; IBA:GO_Central. # GO_function GO:0048027 mRNA 5'-UTR binding; IDA:EcoCyc. # GO_function GO:0070181 small ribosomal subunit rRNA binding; IDA:EcoCyc. # GO_process GO:0006412 translation; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003729 mRNA binding # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_function GO:0019843 rRNA binding # GOslim_process GO:0006412 translation # Gene3D 3.30.70.60 -; 1. # HAMAP MF_00360 Ribosomal_S6 # INTERACTION RS6_ECOLI P0A7T7 rpsR; NbExp=4; IntAct=EBI-543068, EBI-548844; # IntAct P02358 57 # InterPro IPR000529 Ribosomal_S6 # InterPro IPR014717 Transl_elong_EF1B/ribosomal_S6 # InterPro IPR020814 Ribosomal_S6_plastid/chlpt # InterPro IPR020815 Ribosomal_S6_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=15187.2; Method=MALDI; Range=1-131; Evidence={ECO:0000269|PubMed 10094780}; # Organism RS6_ECOLI Escherichia coli (strain K12) # PATRIC 48667972 VBIEscCol107702_4239 # PDB 1EG0 EM; 11.50 A; C=1-97 # PDB 1M5G Model; -; F=1-100 # PDB 2YKR EM; 9.80 A; F=1-100 # PDB 3IY8 EM; 14.10 A; F=2-100 # PDB 3J9Y EM; 3.90 A; f=1-135 # PDB 3J9Z EM; 3.60 A; SF=1-135 # PDB 3JA1 EM; 3.60 A; SF=1-135 # PDB 3JBU EM; 3.64 A; F=1-131 # PDB 3JBV EM; 3.32 A; F=1-131 # PDB 3JCD EM; 3.70 A; f=1-135 # PDB 3JCE EM; 3.20 A; f=1-135 # PDB 3JCJ EM; 3.70 A; n=1-135 # PDB 3JCN EM; 4.60 A; i=1-135 # PDB 4A2I EM; 16.50 A; F=1-100 # PDB 4ADV EM; 13.50 A; F=1-135 # PDB 4U1U X-ray; 2.95 A; AF/CF=1-100 # PDB 4U1V X-ray; 3.00 A; AF/CF=1-100 # PDB 4U20 X-ray; 2.90 A; AF/CF=1-100 # PDB 4U24 X-ray; 2.90 A; AF/CF=1-100 # PDB 4U25 X-ray; 2.90 A; AF/CF=1-100 # PDB 4U26 X-ray; 2.80 A; AF/CF=1-100 # PDB 4U27 X-ray; 2.80 A; AF/CF=1-100 # PDB 4V47 EM; 12.30 A; BF=1-135 # PDB 4V48 EM; 11.50 A; BF=1-135 # PDB 4V4H X-ray; 3.46 A; AF/CF=1-135 # PDB 4V4Q X-ray; 3.46 A; AF/CF=1-135 # PDB 4V4V EM; 15.00 A; AF=1-95 # PDB 4V4W EM; 15.00 A; AF=1-95 # PDB 4V50 X-ray; 3.22 A; AF/CF=1-135 # PDB 4V52 X-ray; 3.21 A; AF/CF=1-135 # PDB 4V53 X-ray; 3.54 A; AF/CF=1-135 # PDB 4V54 X-ray; 3.30 A; AF/CF=1-135 # PDB 4V55 X-ray; 4.00 A; AF/CF=1-135 # PDB 4V56 X-ray; 3.93 A; AF/CF=1-135 # PDB 4V57 X-ray; 3.50 A; AF/CF=1-135 # PDB 4V5B X-ray; 3.74 A; BF/DF=1-135 # PDB 4V5H EM; 5.80 A; AF=1-100 # PDB 4V5Y X-ray; 4.45 A; AF/CF=1-135 # PDB 4V64 X-ray; 3.50 A; AF/CF=1-135 # PDB 4V65 EM; 9.00 A; AT=1-135 # PDB 4V66 EM; 9.00 A; AT=1-135 # PDB 4V69 EM; 6.70 A; AF=1-100 # PDB 4V6C X-ray; 3.19 A; AF/CF=1-135 # PDB 4V6D X-ray; 3.81 A; AF/CF=1-135 # PDB 4V6E X-ray; 3.71 A; AF/CF=1-135 # PDB 4V6K EM; 8.25 A; BJ=1-135 # PDB 4V6L EM; 13.20 A; AJ=1-135 # PDB 4V6M EM; 7.10 A; AF=1-135 # PDB 4V6N EM; 12.10 A; BI=1-135 # PDB 4V6O EM; 14.70 A; AI=1-135 # PDB 4V6P EM; 13.50 A; AI=1-135 # PDB 4V6Q EM; 11.50 A; AI=1-135 # PDB 4V6R EM; 11.50 A; AI=1-135 # PDB 4V6S EM; 13.10 A; BH=1-135 # PDB 4V6T EM; 8.30 A; AF=1-100 # PDB 4V6V EM; 9.80 A; AF=1-135 # PDB 4V6Y EM; 12.00 A; AF=1-100 # PDB 4V6Z EM; 12.00 A; AF=1-100 # PDB 4V70 EM; 17.00 A; AF=1-100 # PDB 4V71 EM; 20.00 A; AF=1-100 # PDB 4V72 EM; 13.00 A; AF=1-100 # PDB 4V73 EM; 15.00 A; AF=1-100 # PDB 4V74 EM; 17.00 A; AF=1-100 # PDB 4V75 EM; 12.00 A; AF=1-100 # PDB 4V76 EM; 17.00 A; AF=1-100 # PDB 4V77 EM; 17.00 A; AF=1-100 # PDB 4V78 EM; 20.00 A; AF=1-100 # PDB 4V79 EM; 15.00 A; AF=1-100 # PDB 4V7A EM; 9.00 A; AF=1-100 # PDB 4V7B EM; 6.80 A; AF=1-135 # PDB 4V7C EM; 7.60 A; AF=1-131 # PDB 4V7D EM; 7.60 A; BF=1-131 # PDB 4V7I EM; 9.60 A; BF=1-135 # PDB 4V7S X-ray; 3.25 A; AF/CF=1-100 # PDB 4V7T X-ray; 3.19 A; AF/CF=1-100 # PDB 4V7U X-ray; 3.10 A; AF/CF=1-100 # PDB 4V7V X-ray; 3.29 A; AF/CF=1-100 # PDB 4V85 X-ray; 3.20 A; F=1-131 # PDB 4V89 X-ray; 3.70 A; AF=1-135 # PDB 4V9C X-ray; 3.30 A; AF/CF=1-135 # PDB 4V9D X-ray; 3.00 A; AF/BF=1-100 # PDB 4V9O X-ray; 2.90 A; BF/DF/FF/HF=1-135 # PDB 4V9P X-ray; 2.90 A; BF/DF/FF/HF=1-135 # PDB 4WF1 X-ray; 3.09 A; AF/CF=1-100 # PDB 4WOI X-ray; 3.00 A; AF/DF=1-135 # PDB 4WWW X-ray; 3.10 A; QF/XF=1-100 # PDB 4YBB X-ray; 2.10 A; AF/BF=1-106 # PDB 5AFI EM; 2.90 A; f=1-135 # PDB 5IQR EM; 3.00 A; k=1-135 # PDB 5IT8 X-ray; 3.12 A; AF/BF=1-106 # PDB 5J5B X-ray; 2.80 A; AF/BF=1-106 # PDB 5J7L X-ray; 3.00 A; AF/BF=1-106 # PDB 5J88 X-ray; 3.32 A; AF/BF=1-106 # PDB 5J8A X-ray; 3.10 A; AF/BF=1-106 # PDB 5J91 X-ray; 2.96 A; AF/BF=1-106 # PDB 5JC9 X-ray; 3.03 A; AF/BF=1-106 # PDB 5JTE EM; 3.60 A; AF=1-135 # PDB 5JU8 EM; 3.60 A; AF=1-135 # PDB 5KCR EM; 3.60 A; 1f=1-135 # PDB 5KCS EM; 3.90 A; 1f=1-135 # PDB 5KPS EM; 3.90 A; 11=1-135 # PDB 5KPV EM; 4.10 A; 10=1-135 # PDB 5KPW EM; 3.90 A; 10=1-135 # PDB 5KPX EM; 3.90 A; 10=1-135 # PDB 5L3P EM; 3.70 A; f=1-135 # PIR C65231 R3EC6 # PROSITE PS01048 RIBOSOMAL_S6 # PTM RS6_ECOLI 5 different forms of the protein, varying only in the number of C-terminal glutamate residues, were isolated. The sequence shown is form S6-6, which is the longest. The first two Glu are encoded by the rpsF gene, the other Glu are added post- translationally by the RimK enzyme. # Pfam PF01250 Ribosomal_S6 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RS6_ECOLI 30S ribosomal protein S6 # RecName RS6_ECOLI 30S ribosomal protein S6 # RecName RS6_ECOLI 30S ribosomal protein S6, fully modified isoform # RecName RS6_ECOLI 30S ribosomal protein S6, fully modified isoform # RecName RS6_ECOLI 30S ribosomal protein S6, non-modified isoform # RefSeq NP_418621 NC_000913.3 # SEQUENCE CAUTION RS6_ECOLI Sequence=AAA97096.1; Type=Miscellaneous discrepancy; Note=Up to 4 Glu residues can be added post-translationally.; Evidence={ECO 0000305}; Sequence=AAC77157.5; Type=Miscellaneous discrepancy; Note=Up to 4 Glu residues can be added post-translationally.; Evidence={ECO 0000305}; Sequence=BAE78201.1; Type=Miscellaneous discrepancy; Note=Up to 4 Glu residues can be added post-translationally.; Evidence={ECO 0000305}; Sequence=CAA27652.1; Type=Miscellaneous discrepancy; Note=Up to 4 Glu residues can be added post-translationally.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ribosomal protein S6P family. {ECO 0000305}. # SUBUNIT Part of the 30S ribosomal subunit. Interacts weakly with L2 in one of the 3.5 A resolved structures (PubMed:16272117). {ECO 0000269|PubMed:16272117}. # SUPFAM SSF54995 SSF54995 # TIGRFAMs TIGR00166 S6 # eggNOG COG0360 LUCA # eggNOG ENOG4108ZDX Bacteria BLAST swissprot:RS6_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RS6_ECOLI BioCyc ECOL316407:JW4158-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4158-MONOMER BioCyc EcoCyc:EG10905-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10905-MONOMER BioCyc MetaCyc:EG10905-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10905-MONOMER COG COG0360 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0360 DIP DIP-10782N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10782N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1006/jmbi.1998.1726 http://dx.doi.org/10.1006/jmbi.1998.1726 DOI 10.1007/BF00330199 http://dx.doi.org/10.1007/BF00330199 DOI 10.1016/S0092-8674(03)00427-6 http://dx.doi.org/10.1016/S0092-8674(03)00427-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb841 http://dx.doi.org/10.1038/nsb841 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1111/j.1432-1033.1977.tb11551.x http://dx.doi.org/10.1111/j.1432-1033.1977.tb11551.x DOI 10.1111/j.1574-6968.1998.tb13343.x http://dx.doi.org/10.1111/j.1574-6968.1998.tb13343.x DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X04022 http://www.ebi.ac.uk/ena/data/view/X04022 EchoBASE EB0898 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0898 EcoGene EG10905 http://www.ecogene.org/geneInfo.php?eg_id=EG10905 EnsemblBacteria AAC77157 http://www.ensemblgenomes.org/id/AAC77157 EnsemblBacteria AAC77157 http://www.ensemblgenomes.org/id/AAC77157 EnsemblBacteria BAE78201 http://www.ensemblgenomes.org/id/BAE78201 EnsemblBacteria BAE78201 http://www.ensemblgenomes.org/id/BAE78201 EnsemblBacteria BAE78201 http://www.ensemblgenomes.org/id/BAE78201 EnsemblBacteria b4200 http://www.ensemblgenomes.org/id/b4200 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0022627 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022627 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_function GO:0048027 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048027 GO_function GO:0070181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070181 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003729 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003729 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 Gene3D 3.30.70.60 http://www.cathdb.info/version/latest/superfamily/3.30.70.60 GeneID 948723 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948723 HAMAP MF_00360 http://hamap.expasy.org/unirule/MF_00360 HOGENOM HOG000040438 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000040438&db=HOGENOM6 InParanoid P02358 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P02358 IntAct P02358 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P02358* InterPro IPR000529 http://www.ebi.ac.uk/interpro/entry/IPR000529 InterPro IPR014717 http://www.ebi.ac.uk/interpro/entry/IPR014717 InterPro IPR020814 http://www.ebi.ac.uk/interpro/entry/IPR020814 InterPro IPR020815 http://www.ebi.ac.uk/interpro/entry/IPR020815 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW4158 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4158 KEGG_Gene eco:b4200 http://www.genome.jp/dbget-bin/www_bget?eco:b4200 KEGG_Orthology KO:K02990 http://www.genome.jp/dbget-bin/www_bget?KO:K02990 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 MINT MINT-1279331 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1279331 OMA ITEASPM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ITEASPM PDB 1EG0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1EG0 PDB 1M5G http://www.ebi.ac.uk/pdbe-srv/view/entry/1M5G PDB 2YKR http://www.ebi.ac.uk/pdbe-srv/view/entry/2YKR PDB 3IY8 http://www.ebi.ac.uk/pdbe-srv/view/entry/3IY8 PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 4A2I http://www.ebi.ac.uk/pdbe-srv/view/entry/4A2I PDB 4ADV http://www.ebi.ac.uk/pdbe-srv/view/entry/4ADV PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4V47 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V47 PDB 4V48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V48 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 1EG0 http://www.ebi.ac.uk/pdbsum/1EG0 PDBsum 1M5G http://www.ebi.ac.uk/pdbsum/1M5G PDBsum 2YKR http://www.ebi.ac.uk/pdbsum/2YKR PDBsum 3IY8 http://www.ebi.ac.uk/pdbsum/3IY8 PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 4A2I http://www.ebi.ac.uk/pdbsum/4A2I PDBsum 4ADV http://www.ebi.ac.uk/pdbsum/4ADV PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4V47 http://www.ebi.ac.uk/pdbsum/4V47 PDBsum 4V48 http://www.ebi.ac.uk/pdbsum/4V48 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PROSITE PS01048 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01048 PSORT swissprot:RS6_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RS6_ECOLI PSORT-B swissprot:RS6_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RS6_ECOLI PSORT2 swissprot:RS6_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RS6_ECOLI Pfam PF01250 http://pfam.xfam.org/family/PF01250 Phobius swissprot:RS6_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RS6_ECOLI PhylomeDB P02358 http://phylomedb.org/?seqid=P02358 ProteinModelPortal P02358 http://www.proteinmodelportal.org/query/uniprot/P02358 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 12244297 http://www.ncbi.nlm.nih.gov/pubmed/12244297 PubMed 12809609 http://www.ncbi.nlm.nih.gov/pubmed/12809609 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 328274 http://www.ncbi.nlm.nih.gov/pubmed/328274 PubMed 3528756 http://www.ncbi.nlm.nih.gov/pubmed/3528756 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 PubMed 9868784 http://www.ncbi.nlm.nih.gov/pubmed/9868784 RefSeq NP_418621 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418621 SMR P02358 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P02358 STRING 511145.b4200 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4200&targetmode=cogs STRING COG0360 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0360&targetmode=cogs SUPFAM SSF54995 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54995 SWISS-2DPAGE P02358 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P02358 TIGRFAMs TIGR00166 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00166 UniProtKB RS6_ECOLI http://www.uniprot.org/uniprot/RS6_ECOLI UniProtKB-AC P02358 http://www.uniprot.org/uniprot/P02358 charge swissprot:RS6_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RS6_ECOLI eggNOG COG0360 http://eggnogapi.embl.de/nog_data/html/tree/COG0360 eggNOG ENOG4108ZDX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZDX epestfind swissprot:RS6_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RS6_ECOLI garnier swissprot:RS6_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RS6_ECOLI helixturnhelix swissprot:RS6_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RS6_ECOLI hmoment swissprot:RS6_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RS6_ECOLI iep swissprot:RS6_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RS6_ECOLI inforesidue swissprot:RS6_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RS6_ECOLI octanol swissprot:RS6_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RS6_ECOLI pepcoil swissprot:RS6_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RS6_ECOLI pepdigest swissprot:RS6_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RS6_ECOLI pepinfo swissprot:RS6_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RS6_ECOLI pepnet swissprot:RS6_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RS6_ECOLI pepstats swissprot:RS6_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RS6_ECOLI pepwheel swissprot:RS6_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RS6_ECOLI pepwindow swissprot:RS6_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RS6_ECOLI sigcleave swissprot:RS6_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RS6_ECOLI ## Database ID URL or Descriptions # BioGrid 4260266 2 # ENZYME REGULATION NemR is inactivated by the addition of N- ethylmaleimide (NEM) and other Cys modification reagents. {ECO:0000269|PubMed 18567656}. # EcoGene EG13947 nemR # FUNCTION NEMR_ECOLI Represses the transcription of the nemRA operon by binding to the nemR box. {ECO 0000269|PubMed 18567656}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0000976 transcription regulatory region sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.357.10 -; 1. # INDUCTION Autoregulated. {ECO:0000269|PubMed 18567656}. # INTERACTION NEMR_ECOLI P04951 kdsB; NbExp=2; IntAct=EBI-544803, EBI-544810; # InterPro IPR001647 HTH_TetR # InterPro IPR009057 Homeodomain-like # InterPro IPR011075 Tet_transcr_reg_TetR-rel_C # InterPro IPR015893 Tet_transcr_reg_TetR-like_C # KEGG_Brite ko03000 Transcription factors # Organism NEMR_ECOLI Escherichia coli (strain K12) # PATRIC 32118600 VBIEscCol129921_1720 # PDB 4YZE X-ray; 2.20 A; A/B/C/D=1-199 # PIR C64922 C64922 # PROSITE PS50977 HTH_TETR_2 # Pfam PF00440 TetR_N # Pfam PF16925 TetR_C_13 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NEMR_ECOLI HTH-type transcriptional repressor NemR # RefSeq NP_416166 NC_000913.3 # RefSeq WP_001032936 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAE76492.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Contains 1 HTH tetR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00335}. # SUPFAM SSF46689 SSF46689 # SUPFAM SSF48498 SSF48498 # eggNOG ENOG4108WUH Bacteria # eggNOG ENOG4111IYW LUCA BLAST swissprot:NEMR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NEMR_ECOLI BioCyc ECOL316407:JW5874-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5874-MONOMER BioCyc EcoCyc:G6889-MONOMER http://biocyc.org/getid?id=EcoCyc:G6889-MONOMER COG COG1309 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1309 DIP DIP-48165N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48165N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00459-08 http://dx.doi.org/10.1128/JB.00459-08 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3705 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3705 EcoGene EG13947 http://www.ecogene.org/geneInfo.php?eg_id=EG13947 EnsemblBacteria AAC74721 http://www.ensemblgenomes.org/id/AAC74721 EnsemblBacteria AAC74721 http://www.ensemblgenomes.org/id/AAC74721 EnsemblBacteria BAE76492 http://www.ensemblgenomes.org/id/BAE76492 EnsemblBacteria BAE76492 http://www.ensemblgenomes.org/id/BAE76492 EnsemblBacteria BAE76492 http://www.ensemblgenomes.org/id/BAE76492 EnsemblBacteria b1649 http://www.ensemblgenomes.org/id/b1649 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000976 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000976 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.357.10 http://www.cathdb.info/version/latest/superfamily/1.10.357.10 GeneID 946166 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946166 HOGENOM HOG000161259 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000161259&db=HOGENOM6 InParanoid P67430 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P67430 IntAct P67430 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P67430* InterPro IPR001647 http://www.ebi.ac.uk/interpro/entry/IPR001647 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR011075 http://www.ebi.ac.uk/interpro/entry/IPR011075 InterPro IPR015893 http://www.ebi.ac.uk/interpro/entry/IPR015893 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW5874 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5874 KEGG_Gene eco:b1649 http://www.genome.jp/dbget-bin/www_bget?eco:b1649 KEGG_Orthology KO:K16137 http://www.genome.jp/dbget-bin/www_bget?KO:K16137 OMA WIDLHER http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WIDLHER PDB 4YZE http://www.ebi.ac.uk/pdbe-srv/view/entry/4YZE PDBsum 4YZE http://www.ebi.ac.uk/pdbsum/4YZE PROSITE PS50977 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50977 PSORT swissprot:NEMR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NEMR_ECOLI PSORT-B swissprot:NEMR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NEMR_ECOLI PSORT2 swissprot:NEMR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NEMR_ECOLI Pfam PF00440 http://pfam.xfam.org/family/PF00440 Pfam PF16925 http://pfam.xfam.org/family/PF16925 Phobius swissprot:NEMR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NEMR_ECOLI PhylomeDB P67430 http://phylomedb.org/?seqid=P67430 ProteinModelPortal P67430 http://www.proteinmodelportal.org/query/uniprot/P67430 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18567656 http://www.ncbi.nlm.nih.gov/pubmed/18567656 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416166 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416166 RefSeq WP_001032936 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001032936 SMR P67430 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P67430 STRING 511145.b1649 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1649&targetmode=cogs STRING COG1309 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1309&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF48498 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48498 UniProtKB NEMR_ECOLI http://www.uniprot.org/uniprot/NEMR_ECOLI UniProtKB-AC P67430 http://www.uniprot.org/uniprot/P67430 charge swissprot:NEMR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NEMR_ECOLI eggNOG ENOG4108WUH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108WUH eggNOG ENOG4111IYW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111IYW epestfind swissprot:NEMR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NEMR_ECOLI garnier swissprot:NEMR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NEMR_ECOLI helixturnhelix swissprot:NEMR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NEMR_ECOLI hmoment swissprot:NEMR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NEMR_ECOLI iep swissprot:NEMR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NEMR_ECOLI inforesidue swissprot:NEMR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NEMR_ECOLI octanol swissprot:NEMR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NEMR_ECOLI pepcoil swissprot:NEMR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NEMR_ECOLI pepdigest swissprot:NEMR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NEMR_ECOLI pepinfo swissprot:NEMR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NEMR_ECOLI pepnet swissprot:NEMR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NEMR_ECOLI pepstats swissprot:NEMR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NEMR_ECOLI pepwheel swissprot:NEMR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NEMR_ECOLI pepwindow swissprot:NEMR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NEMR_ECOLI sigcleave swissprot:NEMR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NEMR_ECOLI ## Database ID URL or Descriptions # BRENDA 3.5.2 2026 # BioGrid 4261761 17 # CATALYTIC ACTIVITY PYRC_ECOLI (S)-dihydroorotate + H(2)O = N-carbamoyl-L- aspartate. # CDD cd01294 DHOase # COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI 29105; Note=Binds 2 Zn(2+) ions per subunit.; # EcoGene EG10806 pyrC # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004151 dihydroorotase activity; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_process GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process; IMP:EcoCyc. # GO_process GO:0006221 pyrimidine nucleotide biosynthetic process; IBA:GO_Central. # GO_process GO:0044205 'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # HAMAP MF_00219 PyrC_type1 # IntAct P05020 6 # InterPro IPR002195 Dihydroorotase_CS # InterPro IPR004721 DHOdimr # InterPro IPR006680 Amidohydro-rel # InterPro IPR032466 Metal_Hydrolase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00240 Pyrimidine metabolism # Organism PYRC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11647:SF59 PTHR11647:SF59 # PATHWAY Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate step 3/3. # PATRIC 32117363 VBIEscCol129921_1104 # PDB 1J79 X-ray; 1.70 A; A/B=2-348 # PDB 1XGE X-ray; 1.90 A; A/B=2-348 # PDB 2E25 X-ray; 2.70 A; A=2-348 # PDB 2EG6 X-ray; 1.70 A; A/B=2-348 # PDB 2EG7 X-ray; 2.00 A; A/B=2-348 # PDB 2EG8 X-ray; 2.20 A; A/B=2-348 # PDB 2Z24 X-ray; 1.90 A; A/B=2-348 # PDB 2Z25 X-ray; 1.87 A; A/B=2-348 # PDB 2Z26 X-ray; 1.29 A; A/B=2-348 # PDB 2Z27 X-ray; 1.87 A; A/B=2-348 # PDB 2Z28 X-ray; 1.87 A; A/B=2-348 # PDB 2Z29 X-ray; 1.90 A; A/B=2-348 # PDB 2Z2A X-ray; 1.87 A; A/B=2-348 # PDB 2Z2B X-ray; 1.85 A; A=2-348 # PIR A25008 DEECOO # PIRSF PIRSF001237 DHOdimr # PROSITE PS00482 DIHYDROOROTASE_1 # PROSITE PS00483 DIHYDROOROTASE_2 # Pfam PF01979 Amidohydro_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PYRC_ECOLI Dihydroorotase # RefSeq NP_415580 NC_000913.3 # RefSeq WP_000126534 NZ_LN832404.1 # SIMILARITY Belongs to the DHOase family. Type 1 subfamily. {ECO 0000305}. # SUBUNIT PYRC_ECOLI Homodimer. # SUPFAM SSF51556 SSF51556 # TIGRFAMs TIGR00856 pyrC_dimer # UniPathway UPA00070 UER00117 # eggNOG COG0418 LUCA # eggNOG ENOG4105EKE Bacteria BLAST swissprot:PYRC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PYRC_ECOLI BioCyc ECOL316407:JW1049-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1049-MONOMER BioCyc EcoCyc:DIHYDROOROT-MONOMER http://biocyc.org/getid?id=EcoCyc:DIHYDROOROT-MONOMER BioCyc MetaCyc:DIHYDROOROT-MONOMER http://biocyc.org/getid?id=MetaCyc:DIHYDROOROT-MONOMER COG COG0044 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0044 COG COG0418 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0418 DIP DIP-10624N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10624N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1021/bi010682i http://dx.doi.org/10.1021/bi010682i DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1432-1033.1986.tb09942.x http://dx.doi.org/10.1111/j.1432-1033.1986.tb09942.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.5.2.3 http://www.genome.jp/dbget-bin/www_bget?EC:3.5.2.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D31709 http://www.ebi.ac.uk/ena/data/view/D31709 EMBL M16752 http://www.ebi.ac.uk/ena/data/view/M16752 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X04469 http://www.ebi.ac.uk/ena/data/view/X04469 ENZYME 3.5.2.3 http://enzyme.expasy.org/EC/3.5.2.3 EchoBASE EB0799 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0799 EcoGene EG10806 http://www.ecogene.org/geneInfo.php?eg_id=EG10806 EnsemblBacteria AAC74146 http://www.ensemblgenomes.org/id/AAC74146 EnsemblBacteria AAC74146 http://www.ensemblgenomes.org/id/AAC74146 EnsemblBacteria BAA35870 http://www.ensemblgenomes.org/id/BAA35870 EnsemblBacteria BAA35870 http://www.ensemblgenomes.org/id/BAA35870 EnsemblBacteria BAA35870 http://www.ensemblgenomes.org/id/BAA35870 EnsemblBacteria b1062 http://www.ensemblgenomes.org/id/b1062 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004151 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004151 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_process GO:0006207 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006207 GO_process GO:0006221 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006221 GO_process GO:0044205 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044205 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 945787 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945787 HAMAP MF_00219 http://hamap.expasy.org/unirule/MF_00219 HOGENOM HOG000256259 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000256259&db=HOGENOM6 InParanoid P05020 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P05020 IntAct P05020 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P05020* IntEnz 3.5.2.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.2.3 InterPro IPR002195 http://www.ebi.ac.uk/interpro/entry/IPR002195 InterPro IPR004721 http://www.ebi.ac.uk/interpro/entry/IPR004721 InterPro IPR006680 http://www.ebi.ac.uk/interpro/entry/IPR006680 InterPro IPR032466 http://www.ebi.ac.uk/interpro/entry/IPR032466 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1049 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1049 KEGG_Gene eco:b1062 http://www.genome.jp/dbget-bin/www_bget?eco:b1062 KEGG_Orthology KO:K01465 http://www.genome.jp/dbget-bin/www_bget?KO:K01465 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Reaction rn:R01993 http://www.genome.jp/dbget-bin/www_bget?rn:R01993 OMA YAEAFEQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YAEAFEQ PANTHER PTHR11647:SF59 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11647:SF59 PDB 1J79 http://www.ebi.ac.uk/pdbe-srv/view/entry/1J79 PDB 1XGE http://www.ebi.ac.uk/pdbe-srv/view/entry/1XGE PDB 2E25 http://www.ebi.ac.uk/pdbe-srv/view/entry/2E25 PDB 2EG6 http://www.ebi.ac.uk/pdbe-srv/view/entry/2EG6 PDB 2EG7 http://www.ebi.ac.uk/pdbe-srv/view/entry/2EG7 PDB 2EG8 http://www.ebi.ac.uk/pdbe-srv/view/entry/2EG8 PDB 2Z24 http://www.ebi.ac.uk/pdbe-srv/view/entry/2Z24 PDB 2Z25 http://www.ebi.ac.uk/pdbe-srv/view/entry/2Z25 PDB 2Z26 http://www.ebi.ac.uk/pdbe-srv/view/entry/2Z26 PDB 2Z27 http://www.ebi.ac.uk/pdbe-srv/view/entry/2Z27 PDB 2Z28 http://www.ebi.ac.uk/pdbe-srv/view/entry/2Z28 PDB 2Z29 http://www.ebi.ac.uk/pdbe-srv/view/entry/2Z29 PDB 2Z2A http://www.ebi.ac.uk/pdbe-srv/view/entry/2Z2A PDB 2Z2B http://www.ebi.ac.uk/pdbe-srv/view/entry/2Z2B PDBsum 1J79 http://www.ebi.ac.uk/pdbsum/1J79 PDBsum 1XGE http://www.ebi.ac.uk/pdbsum/1XGE PDBsum 2E25 http://www.ebi.ac.uk/pdbsum/2E25 PDBsum 2EG6 http://www.ebi.ac.uk/pdbsum/2EG6 PDBsum 2EG7 http://www.ebi.ac.uk/pdbsum/2EG7 PDBsum 2EG8 http://www.ebi.ac.uk/pdbsum/2EG8 PDBsum 2Z24 http://www.ebi.ac.uk/pdbsum/2Z24 PDBsum 2Z25 http://www.ebi.ac.uk/pdbsum/2Z25 PDBsum 2Z26 http://www.ebi.ac.uk/pdbsum/2Z26 PDBsum 2Z27 http://www.ebi.ac.uk/pdbsum/2Z27 PDBsum 2Z28 http://www.ebi.ac.uk/pdbsum/2Z28 PDBsum 2Z29 http://www.ebi.ac.uk/pdbsum/2Z29 PDBsum 2Z2A http://www.ebi.ac.uk/pdbsum/2Z2A PDBsum 2Z2B http://www.ebi.ac.uk/pdbsum/2Z2B PROSITE PS00482 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00482 PROSITE PS00483 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00483 PSORT swissprot:PYRC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PYRC_ECOLI PSORT-B swissprot:PYRC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PYRC_ECOLI PSORT2 swissprot:PYRC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PYRC_ECOLI Pfam PF01979 http://pfam.xfam.org/family/PF01979 Phobius swissprot:PYRC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PYRC_ECOLI PhylomeDB P05020 http://phylomedb.org/?seqid=P05020 ProteinModelPortal P05020 http://www.proteinmodelportal.org/query/uniprot/P05020 PubMed 11401542 http://www.ncbi.nlm.nih.gov/pubmed/11401542 PubMed 1671037 http://www.ncbi.nlm.nih.gov/pubmed/1671037 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2876892 http://www.ncbi.nlm.nih.gov/pubmed/2876892 PubMed 2885307 http://www.ncbi.nlm.nih.gov/pubmed/2885307 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_415580 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415580 RefSeq WP_000126534 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000126534 SMR P05020 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P05020 STRING 511145.b1062 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1062&targetmode=cogs STRING COG0044 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0044&targetmode=cogs STRING COG0418 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0418&targetmode=cogs SUPFAM SSF51556 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51556 TIGRFAMs TIGR00856 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00856 UniProtKB PYRC_ECOLI http://www.uniprot.org/uniprot/PYRC_ECOLI UniProtKB-AC P05020 http://www.uniprot.org/uniprot/P05020 charge swissprot:PYRC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PYRC_ECOLI eggNOG COG0418 http://eggnogapi.embl.de/nog_data/html/tree/COG0418 eggNOG ENOG4105EKE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EKE epestfind swissprot:PYRC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PYRC_ECOLI garnier swissprot:PYRC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PYRC_ECOLI helixturnhelix swissprot:PYRC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PYRC_ECOLI hmoment swissprot:PYRC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PYRC_ECOLI iep swissprot:PYRC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PYRC_ECOLI inforesidue swissprot:PYRC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PYRC_ECOLI octanol swissprot:PYRC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PYRC_ECOLI pepcoil swissprot:PYRC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PYRC_ECOLI pepdigest swissprot:PYRC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PYRC_ECOLI pepinfo swissprot:PYRC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PYRC_ECOLI pepnet swissprot:PYRC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PYRC_ECOLI pepstats swissprot:PYRC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PYRC_ECOLI pepwheel swissprot:PYRC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PYRC_ECOLI pepwindow swissprot:PYRC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PYRC_ECOLI sigcleave swissprot:PYRC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PYRC_ECOLI ## Database ID URL or Descriptions # BioGrid 4263476 32 # DrugBank DB02325 Isopropyl Alcohol # EcoGene EG11281 mutL # FUNCTION MUTL_ECOLI This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of the final effector complex. The ATPase activity of MutL is stimulated by DNA. # GO_component GO:0032300 mismatch repair complex; IGI:EcoliWiki. # GO_function GO:0003677 DNA binding; IDA:EcoliWiki. # GO_function GO:0003697 single-stranded DNA binding; IBA:GO_Central. # GO_function GO:0005524 ATP binding; IDA:EcoliWiki. # GO_function GO:0016887 ATPase activity; IDA:EcoliWiki. # GO_function GO:0030983 mismatched DNA binding; IEA:InterPro. # GO_process GO:0000018 regulation of DNA recombination; IMP:EcoliWiki. # GO_process GO:0006298 mismatch repair; IDA:EcoliWiki. # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # Gene3D 3.30.230.10 -; 1. # Gene3D 3.30.565.10 -; 1. # HAMAP MF_00149 DNA_mis_repair # INTERACTION MUTL_ECOLI Self; NbExp=4; IntAct=EBI-554913, EBI-554913; P06710-2 dnaX; NbExp=2; IntAct=EBI-554913, EBI-2604194; P28630 holA; NbExp=2; IntAct=EBI-554913, EBI-549153; P28631 holB; NbExp=2; IntAct=EBI-554913, EBI-549161; P06722 mutH; NbExp=8; IntAct=EBI-554913, EBI-545170; P0A7G6 recA; NbExp=3; IntAct=EBI-554913, EBI-370331; P03018 uvrD; NbExp=7; IntAct=EBI-554913, EBI-559573; P09184 vsr; NbExp=3; IntAct=EBI-554913, EBI-765033; # IntAct P23367 13 # InterPro IPR002099 DNA_mismatch_repair_fam # InterPro IPR003594 HATPase_C # InterPro IPR013507 DNA_mismatch_repair_C # InterPro IPR014721 Ribosomal_S5_D2-typ_fold_subgr # InterPro IPR014762 DNA_mismatch_repair_CS # InterPro IPR014790 MutL_C # InterPro IPR020568 Ribosomal_S5_D2-typ_fold # InterPro IPR020667 DNA_mismatch_repair_MutL # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko03430 Mismatch repair # Organism MUTL_ECOLI Escherichia coli (strain K12) # PATRIC 32123913 VBIEscCol129921_4301 # PDB 1B62 X-ray; 2.10 A; A=1-349 # PDB 1B63 X-ray; 1.90 A; A=1-331 # PDB 1BKN X-ray; 2.90 A; A/B=1-349 # PDB 1NHH X-ray; 2.40 A; A=1-331 # PDB 1NHI X-ray; 2.00 A; A=1-331 # PDB 1NHJ X-ray; 2.30 A; A=1-331 # PDB 1X9Z X-ray; 2.10 A; A/B=432-615 # PDB 5AKB X-ray; 4.71 A; C/D/F=1-349 # PDB 5AKC X-ray; 6.60 A; C/D/G/H/K/L=1-349 # PDB 5AKD X-ray; 7.60 A; C/D/G/H/K/L=1-349 # PIR PH0853 PH0853 # PROSITE PS00058 DNA_MISMATCH_REPAIR_1 # Pfam PF01119 DNA_mis_repair # Pfam PF08676 MutL_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MUTL_ECOLI DNA mismatch repair protein MutL # RefSeq NP_418591 NC_000913.3 # RefSeq WP_001122505 NZ_LN832404.1 # SIMILARITY Belongs to the DNA mismatch repair MutL/HexB family. {ECO 0000305}. # SMART SM00853 MutL_C # SMART SM01340 DNA_mis_repair # SUPFAM SSF54211 SSF54211 # SUPFAM SSF55874 SSF55874 # TIGRFAMs TIGR00585 mutl # eggNOG COG0323 LUCA # eggNOG ENOG4105DC6 Bacteria BLAST swissprot:MUTL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MUTL_ECOLI BioCyc ECOL316407:JW4128-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4128-MONOMER BioCyc EcoCyc:EG11281-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11281-MONOMER BioCyc MetaCyc:EG11281-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11281-MONOMER COG COG0323 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0323 DIP DIP-10285N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10285N DOI 10.1016/S0092-8674(00)80717-5 http://dx.doi.org/10.1016/S0092-8674(00)80717-5 DOI 10.1016/S0092-8674(00)81621-9 http://dx.doi.org/10.1016/S0092-8674(00)81621-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/20.9.2379 http://dx.doi.org/10.1093/nar/20.9.2379 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1111/j.1365-2958.1994.tb00300.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb00300.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB02325 http://www.drugbank.ca/drugs/DB02325 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19346 http://www.ebi.ac.uk/ena/data/view/L19346 EMBL M63655 http://www.ebi.ac.uk/ena/data/view/M63655 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL Z11831 http://www.ebi.ac.uk/ena/data/view/Z11831 EchoBASE EB1258 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1258 EcoGene EG11281 http://www.ecogene.org/geneInfo.php?eg_id=EG11281 EnsemblBacteria AAC77127 http://www.ensemblgenomes.org/id/AAC77127 EnsemblBacteria AAC77127 http://www.ensemblgenomes.org/id/AAC77127 EnsemblBacteria BAE78171 http://www.ensemblgenomes.org/id/BAE78171 EnsemblBacteria BAE78171 http://www.ensemblgenomes.org/id/BAE78171 EnsemblBacteria BAE78171 http://www.ensemblgenomes.org/id/BAE78171 EnsemblBacteria b4170 http://www.ensemblgenomes.org/id/b4170 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0032300 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032300 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003697 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003697 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_function GO:0030983 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030983 GO_process GO:0000018 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000018 GO_process GO:0006298 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006298 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.30.230.10 http://www.cathdb.info/version/latest/superfamily/3.30.230.10 Gene3D 3.30.565.10 http://www.cathdb.info/version/latest/superfamily/3.30.565.10 GeneID 948691 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948691 HAMAP MF_00149 http://hamap.expasy.org/unirule/MF_00149 HOGENOM HOG000256551 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000256551&db=HOGENOM6 InParanoid P23367 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23367 IntAct P23367 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P23367* InterPro IPR002099 http://www.ebi.ac.uk/interpro/entry/IPR002099 InterPro IPR003594 http://www.ebi.ac.uk/interpro/entry/IPR003594 InterPro IPR013507 http://www.ebi.ac.uk/interpro/entry/IPR013507 InterPro IPR014721 http://www.ebi.ac.uk/interpro/entry/IPR014721 InterPro IPR014762 http://www.ebi.ac.uk/interpro/entry/IPR014762 InterPro IPR014790 http://www.ebi.ac.uk/interpro/entry/IPR014790 InterPro IPR020568 http://www.ebi.ac.uk/interpro/entry/IPR020568 InterPro IPR020667 http://www.ebi.ac.uk/interpro/entry/IPR020667 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW4128 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4128 KEGG_Gene eco:b4170 http://www.genome.jp/dbget-bin/www_bget?eco:b4170 KEGG_Orthology KO:K03572 http://www.genome.jp/dbget-bin/www_bget?KO:K03572 KEGG_Pathway ko03430 http://www.genome.jp/kegg-bin/show_pathway?ko03430 MINT MINT-1266937 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1266937 OMA WQQENRQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WQQENRQ PDB 1B62 http://www.ebi.ac.uk/pdbe-srv/view/entry/1B62 PDB 1B63 http://www.ebi.ac.uk/pdbe-srv/view/entry/1B63 PDB 1BKN http://www.ebi.ac.uk/pdbe-srv/view/entry/1BKN PDB 1NHH http://www.ebi.ac.uk/pdbe-srv/view/entry/1NHH PDB 1NHI http://www.ebi.ac.uk/pdbe-srv/view/entry/1NHI PDB 1NHJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1NHJ PDB 1X9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/1X9Z PDB 5AKB http://www.ebi.ac.uk/pdbe-srv/view/entry/5AKB PDB 5AKC http://www.ebi.ac.uk/pdbe-srv/view/entry/5AKC PDB 5AKD http://www.ebi.ac.uk/pdbe-srv/view/entry/5AKD PDBsum 1B62 http://www.ebi.ac.uk/pdbsum/1B62 PDBsum 1B63 http://www.ebi.ac.uk/pdbsum/1B63 PDBsum 1BKN http://www.ebi.ac.uk/pdbsum/1BKN PDBsum 1NHH http://www.ebi.ac.uk/pdbsum/1NHH PDBsum 1NHI http://www.ebi.ac.uk/pdbsum/1NHI PDBsum 1NHJ http://www.ebi.ac.uk/pdbsum/1NHJ PDBsum 1X9Z http://www.ebi.ac.uk/pdbsum/1X9Z PDBsum 5AKB http://www.ebi.ac.uk/pdbsum/5AKB PDBsum 5AKC http://www.ebi.ac.uk/pdbsum/5AKC PDBsum 5AKD http://www.ebi.ac.uk/pdbsum/5AKD PROSITE PS00058 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00058 PSORT swissprot:MUTL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MUTL_ECOLI PSORT-B swissprot:MUTL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MUTL_ECOLI PSORT2 swissprot:MUTL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MUTL_ECOLI Pfam PF01119 http://pfam.xfam.org/family/PF01119 Pfam PF08676 http://pfam.xfam.org/family/PF08676 Phobius swissprot:MUTL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MUTL_ECOLI PhylomeDB P23367 http://phylomedb.org/?seqid=P23367 ProteinModelPortal P23367 http://www.proteinmodelportal.org/query/uniprot/P23367 PubMed 10199405 http://www.ncbi.nlm.nih.gov/pubmed/10199405 PubMed 1594459 http://www.ncbi.nlm.nih.gov/pubmed/1594459 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1999389 http://www.ncbi.nlm.nih.gov/pubmed/1999389 PubMed 7511774 http://www.ncbi.nlm.nih.gov/pubmed/7511774 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9827806 http://www.ncbi.nlm.nih.gov/pubmed/9827806 RefSeq NP_418591 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418591 RefSeq WP_001122505 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001122505 SMART SM00853 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00853 SMART SM01340 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01340 SMR P23367 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P23367 STRING 511145.b4170 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4170&targetmode=cogs STRING COG0323 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0323&targetmode=cogs SUPFAM SSF54211 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54211 SUPFAM SSF55874 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55874 TIGRFAMs TIGR00585 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00585 UniProtKB MUTL_ECOLI http://www.uniprot.org/uniprot/MUTL_ECOLI UniProtKB-AC P23367 http://www.uniprot.org/uniprot/P23367 charge swissprot:MUTL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MUTL_ECOLI eggNOG COG0323 http://eggnogapi.embl.de/nog_data/html/tree/COG0323 eggNOG ENOG4105DC6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DC6 epestfind swissprot:MUTL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MUTL_ECOLI garnier swissprot:MUTL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MUTL_ECOLI helixturnhelix swissprot:MUTL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MUTL_ECOLI hmoment swissprot:MUTL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MUTL_ECOLI iep swissprot:MUTL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MUTL_ECOLI inforesidue swissprot:MUTL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MUTL_ECOLI octanol swissprot:MUTL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MUTL_ECOLI pepcoil swissprot:MUTL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MUTL_ECOLI pepdigest swissprot:MUTL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MUTL_ECOLI pepinfo swissprot:MUTL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MUTL_ECOLI pepnet swissprot:MUTL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MUTL_ECOLI pepstats swissprot:MUTL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MUTL_ECOLI pepwheel swissprot:MUTL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MUTL_ECOLI pepwindow swissprot:MUTL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MUTL_ECOLI sigcleave swissprot:MUTL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MUTL_ECOLI ## Database ID URL or Descriptions # BioGrid 4262311 12 # EcoGene EG13274 yqeK # Organism YQEK_ECOLI Escherichia coli (strain K12) # PIR B65068 B65068 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQEK_ECOLI Uncharacterized protein YqeK # RefSeq NP_417326 NC_000913.3 # RefSeq WP_000350612 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40288.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; BLAST swissprot:YQEK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQEK_ECOLI BioCyc ECOL316407:JW2817-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2817-MONOMER BioCyc EcoCyc:G7469-MONOMER http://biocyc.org/getid?id=EcoCyc:G7469-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U83187 http://www.ebi.ac.uk/ena/data/view/U83187 EchoBASE EB3059 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3059 EcoGene EG13274 http://www.ecogene.org/geneInfo.php?eg_id=EG13274 EnsemblBacteria AAC75888 http://www.ensemblgenomes.org/id/AAC75888 EnsemblBacteria AAC75888 http://www.ensemblgenomes.org/id/AAC75888 EnsemblBacteria BAE76918 http://www.ensemblgenomes.org/id/BAE76918 EnsemblBacteria BAE76918 http://www.ensemblgenomes.org/id/BAE76918 EnsemblBacteria BAE76918 http://www.ensemblgenomes.org/id/BAE76918 EnsemblBacteria b2849 http://www.ensemblgenomes.org/id/b2849 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947329 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947329 HOGENOM HOG000050885 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000050885&db=HOGENOM6 IntAct P77136 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77136* KEGG_Gene ecj:JW2817 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2817 KEGG_Gene eco:b2849 http://www.genome.jp/dbget-bin/www_bget?eco:b2849 OMA WALNSRY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WALNSRY PSORT swissprot:YQEK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQEK_ECOLI PSORT-B swissprot:YQEK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQEK_ECOLI PSORT2 swissprot:YQEK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQEK_ECOLI Phobius swissprot:YQEK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQEK_ECOLI ProteinModelPortal P77136 http://www.proteinmodelportal.org/query/uniprot/P77136 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417326 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417326 RefSeq WP_000350612 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000350612 STRING 511145.b2849 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2849&targetmode=cogs UniProtKB YQEK_ECOLI http://www.uniprot.org/uniprot/YQEK_ECOLI UniProtKB-AC P77136 http://www.uniprot.org/uniprot/P77136 charge swissprot:YQEK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQEK_ECOLI epestfind swissprot:YQEK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQEK_ECOLI garnier swissprot:YQEK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQEK_ECOLI helixturnhelix swissprot:YQEK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQEK_ECOLI hmoment swissprot:YQEK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQEK_ECOLI iep swissprot:YQEK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQEK_ECOLI inforesidue swissprot:YQEK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQEK_ECOLI octanol swissprot:YQEK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQEK_ECOLI pepcoil swissprot:YQEK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQEK_ECOLI pepdigest swissprot:YQEK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQEK_ECOLI pepinfo swissprot:YQEK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQEK_ECOLI pepnet swissprot:YQEK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQEK_ECOLI pepstats swissprot:YQEK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQEK_ECOLI pepwheel swissprot:YQEK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQEK_ECOLI pepwindow swissprot:YQEK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQEK_ECOLI sigcleave swissprot:YQEK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQEK_ECOLI ## Database ID URL or Descriptions # BioGrid 4260640 6 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG13162 ybeM # GO_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; IEA:InterPro. # GO_process GO:0006807 nitrogen compound metabolic process; IEA:InterPro. # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_process GO:0008150 biological_process # Gene3D 3.60.110.10 -; 1. # IntAct P39874 2 # InterPro IPR001110 UPF0012_CS # InterPro IPR003010 C-N_Hydrolase # Organism YBEM_ECOLI Escherichia coli (strain K12) # PATRIC 48660478 VBIEscCol107702_0629 # PIR G64796 G64796 # PIR H64796 H64796 # PROSITE PS01227 UPF0012 # PROSITE PS50263 CN_HYDROLASE # Pfam PF00795 CN_hydrolase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBEM_ECOLI Putative hydrolase YbeM # SEQUENCE CAUTION YBEM_ECOLI Sequence=AAA81032.1; Type=Frameshift; Positions=67; Evidence={ECO 0000305}; Sequence=AAB40825.1; Type=Frameshift; Positions=67; Evidence={ECO 0000305}; Sequence=AAB40826.1; Type=Frameshift; Positions=67; Evidence={ECO 0000305}; Sequence=BAA35268.1; Type=Frameshift; Positions=67; Evidence={ECO 0000305}; Sequence=BAA35269.1; Type=Frameshift; Positions=67; Evidence={ECO 0000305}; Sequence=U00096; Type=Frameshift; Positions=67; Evidence={ECO 0000305}; # SIMILARITY Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family. {ECO 0000305}. # SIMILARITY Contains 1 CN hydrolase domain. {ECO:0000255|PROSITE- ProRule PRU00054}. # SUPFAM SSF56317 SSF56317 # eggNOG COG0388 LUCA # eggNOG ENOG4107QPI Bacteria BLAST swissprot:YBEM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBEM_ECOLI BioCyc ECOL316407:JW0620-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0620-MONOMER BioCyc ECOL316407:JW0621-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0621-MONOMER BioCyc EcoCyc:G6348-MONOMER http://biocyc.org/getid?id=EcoCyc:G6348-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1994.tb00424.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb00424.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.5.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.5.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D28497 http://www.ebi.ac.uk/ena/data/view/D28497 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U38811 http://www.ebi.ac.uk/ena/data/view/U38811 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 ENZYME 3.5.-.- http://enzyme.expasy.org/EC/3.5.-.- EcoGene EG13162 http://www.ecogene.org/geneInfo.php?eg_id=EG13162 EnsemblBacteria BAA35268 http://www.ensemblgenomes.org/id/BAA35268 EnsemblBacteria BAA35268 http://www.ensemblgenomes.org/id/BAA35268 EnsemblBacteria BAA35268 http://www.ensemblgenomes.org/id/BAA35268 EnsemblBacteria BAA35269 http://www.ensemblgenomes.org/id/BAA35269 EnsemblBacteria BAA35269 http://www.ensemblgenomes.org/id/BAA35269 EnsemblBacteria BAA35269 http://www.ensemblgenomes.org/id/BAA35269 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GO_process GO:0006807 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006807 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.60.110.10 http://www.cathdb.info/version/latest/superfamily/3.60.110.10 HOGENOM HOG000222700 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000222700&db=HOGENOM6 InParanoid P39874 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39874 IntAct P39874 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39874* IntEnz 3.5 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5 InterPro IPR001110 http://www.ebi.ac.uk/interpro/entry/IPR001110 InterPro IPR003010 http://www.ebi.ac.uk/interpro/entry/IPR003010 KEGG_Gene ecj:JW0620 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0620 KEGG_Gene ecj:JW0621 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0621 OMA ECGTRNI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ECGTRNI PROSITE PS01227 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01227 PROSITE PS50263 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50263 PSORT swissprot:YBEM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBEM_ECOLI PSORT-B swissprot:YBEM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBEM_ECOLI PSORT2 swissprot:YBEM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBEM_ECOLI Pfam PF00795 http://pfam.xfam.org/family/PF00795 Phobius swissprot:YBEM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBEM_ECOLI PhylomeDB P39874 http://phylomedb.org/?seqid=P39874 ProteinModelPortal P39874 http://www.proteinmodelportal.org/query/uniprot/P39874 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7984109 http://www.ncbi.nlm.nih.gov/pubmed/7984109 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SMR P39874 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39874 STRING 316407.4062249 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.4062249&targetmode=cogs SUPFAM SSF56317 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56317 UniProtKB YBEM_ECOLI http://www.uniprot.org/uniprot/YBEM_ECOLI UniProtKB-AC P39874 http://www.uniprot.org/uniprot/P39874 charge swissprot:YBEM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBEM_ECOLI eggNOG COG0388 http://eggnogapi.embl.de/nog_data/html/tree/COG0388 eggNOG ENOG4107QPI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QPI epestfind swissprot:YBEM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBEM_ECOLI garnier swissprot:YBEM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBEM_ECOLI helixturnhelix swissprot:YBEM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBEM_ECOLI hmoment swissprot:YBEM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBEM_ECOLI iep swissprot:YBEM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBEM_ECOLI inforesidue swissprot:YBEM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBEM_ECOLI octanol swissprot:YBEM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBEM_ECOLI pepcoil swissprot:YBEM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBEM_ECOLI pepdigest swissprot:YBEM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBEM_ECOLI pepinfo swissprot:YBEM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBEM_ECOLI pepnet swissprot:YBEM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBEM_ECOLI pepstats swissprot:YBEM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBEM_ECOLI pepwheel swissprot:YBEM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBEM_ECOLI pepwindow swissprot:YBEM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBEM_ECOLI sigcleave swissprot:YBEM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBEM_ECOLI ## Database ID URL or Descriptions # AltName Formyl-coenzyme A transferase {ECO:0000255|HAMAP-Rule MF_00742} # BIOPHYSICOCHEMICAL PROPERTIES FCTA_ECOLI Kinetic parameters KM=180 uM for formyl-CoA (with succinate as acceptor at pH 6.7 and 30 degrees Celsius) {ECO 0000269|PubMed 18245280}; KM=352 uM for formyl-CoA (with oxalate as acceptor at pH 6.7 and 30 degrees Celsius) {ECO 0000269|PubMed 18245280}; KM=510 uM for oxalate (with formyl-CoA as donor at pH 6.7 and 30 degrees Celsius) {ECO 0000269|PubMed 18245280}; KM=80 mM for succinate (with formyl-CoA as donor at pH 6.7 and 30 degrees Celsius) {ECO 0000269|PubMed 18245280}; Note=Kcat is 130 sec(-1) for CoA-transferase activity with formyl-CoA as substrate (with oxalate as acceptor at pH 6.7 and 30 degrees Celsius). Kcat is 5.3 sec(-1) for CoA-transferase activity with formyl-CoA as substrate (with succinate as acceptor at pH 6.7 and 30 degrees Celsius).; # BRENDA 2.8.3.16 2026 # BioGrid 4260863 11 # CATALYTIC ACTIVITY FCTA_ECOLI Formyl-CoA + oxalate = formate + oxalyl-CoA. {ECO 0000255|HAMAP-Rule MF_00742, ECO 0000269|PubMed 18245280}. # DISRUPTION PHENOTYPE Cells lacking this gene show a reduced acid tolerance response (ATR) during the adaptation phase. However the deletion of YfdW has no effect on survival in oxalate-containing challenge medium. {ECO:0000269|PubMed 23335415}. # EcoGene EG14145 frc # FUNCTION FCTA_ECOLI Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate. It can also use succinate as an acceptor. {ECO 0000269|PubMed 12844490, ECO 0000269|PubMed 18245280, ECO 0000269|PubMed 23335415}. # GO_function GO:0033608 formyl-CoA transferase activity; IDA:EcoCyc. # GO_process GO:0033611 oxalate catabolic process; IEA:UniProtKB-UniPathway. # GO_process GO:0071468 cellular response to acidic pH; IMP:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.10540 -; 2. # HAMAP MF_00742 Formyl_CoA_transfer # INDUCTION FCTA_ECOLI By the acid response regulator EvgA. {ECO 0000269|PubMed 12694615, ECO 0000269|PubMed 23335415}. # IntAct P69902 4 # InterPro IPR003673 CoA-Trfase_fam_III # InterPro IPR017659 Formyl_CoA_transfer # InterPro IPR023606 CoA-Trfase_III_dom # KEGG_Brite ko01000 Enzymes # Organism FCTA_ECOLI Escherichia coli (strain K12) # PATHWAY Metabolic intermediate degradation; oxalate degradation; CO(2) and formate from oxalate: step 1/2. {ECO 0000255|HAMAP- Rule:MF_00742}. # PATRIC 32120127 VBIEscCol129921_2472 # PDB 1PQY X-ray; 2.35 A; A=2-416 # PDB 1PT5 X-ray; 2.00 A; A/B=1-416 # PDB 1PT7 X-ray; 1.80 A; A/B=1-416 # PDB 1PT8 X-ray; 2.20 A; A/B=1-416 # PDB 1Q6Y X-ray; 1.99 A; A=2-416 # PDB 1Q7E X-ray; 1.60 A; A=2-416 # PIR C65011 C65011 # Pfam PF02515 CoA_transf_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Formyl-CoA oxalate CoA-transferase # RefSeq NP_416875 NC_000913.3 # RefSeq WP_000106759 NZ_LN832404.1 # SIMILARITY Belongs to the CaiB/BaiF CoA-transferase family. {ECO:0000255|HAMAP-Rule MF_00742}. # SUBUNIT FCTA_ECOLI Homodimer. {ECO 0000255|HAMAP-Rule MF_00742, ECO 0000269|PubMed 12844490, ECO 0000269|PubMed 14993676}. # SUPFAM SSF89796 SSF89796 # TIGRFAMs TIGR03253 oxalate_frc # UniPathway UPA00540 UER00598 # eggNOG COG1804 LUCA # eggNOG ENOG4105C04 Bacteria BLAST swissprot:FCTA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FCTA_ECOLI BioCyc ECOL316407:JW2371-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2371-MONOMER BioCyc EcoCyc:G7237-MONOMER http://biocyc.org/getid?id=EcoCyc:G7237-MONOMER BioCyc MetaCyc:G7237-MONOMER http://biocyc.org/getid?id=MetaCyc:G7237-MONOMER COG COG1804 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1804 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2003.03477.x http://dx.doi.org/10.1046/j.1365-2958.2003.03477.x DOI 10.1074/jbc.C300282200 http://dx.doi.org/10.1074/jbc.C300282200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1107/S0907444904000034 http://dx.doi.org/10.1107/S0907444904000034 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01823-07 http://dx.doi.org/10.1128/JB.01823-07 DOI 10.1128/JB.01936-12 http://dx.doi.org/10.1128/JB.01936-12 EC_number EC:2.8.3.16 {ECO:0000255|HAMAP-Rule:MF_00742} http://www.genome.jp/dbget-bin/www_bget?EC:2.8.3.16 {ECO:0000255|HAMAP-Rule:MF_00742} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.8.3.16 {ECO:0000255|HAMAP-Rule:MF_00742} http://enzyme.expasy.org/EC/2.8.3.16 {ECO:0000255|HAMAP-Rule:MF_00742} EchoBASE EB3897 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3897 EcoGene EG14145 http://www.ecogene.org/geneInfo.php?eg_id=EG14145 EnsemblBacteria AAC75433 http://www.ensemblgenomes.org/id/AAC75433 EnsemblBacteria AAC75433 http://www.ensemblgenomes.org/id/AAC75433 EnsemblBacteria BAA16247 http://www.ensemblgenomes.org/id/BAA16247 EnsemblBacteria BAA16247 http://www.ensemblgenomes.org/id/BAA16247 EnsemblBacteria BAA16247 http://www.ensemblgenomes.org/id/BAA16247 EnsemblBacteria b2374 http://www.ensemblgenomes.org/id/b2374 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0033608 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033608 GO_process GO:0033611 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033611 GO_process GO:0071468 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071468 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.10540 http://www.cathdb.info/version/latest/superfamily/3.40.50.10540 GeneID 946842 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946842 HAMAP MF_00742 http://hamap.expasy.org/unirule/MF_00742 HOGENOM HOG000219745 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219745&db=HOGENOM6 InParanoid P69902 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P69902 IntAct P69902 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69902* IntEnz 2.8.3.16 {ECO:0000255|HAMAP-Rule:MF_00742} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.8.3.16 {ECO:0000255|HAMAP-Rule:MF_00742} InterPro IPR003673 http://www.ebi.ac.uk/interpro/entry/IPR003673 InterPro IPR017659 http://www.ebi.ac.uk/interpro/entry/IPR017659 InterPro IPR023606 http://www.ebi.ac.uk/interpro/entry/IPR023606 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2371 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2371 KEGG_Gene eco:b2374 http://www.genome.jp/dbget-bin/www_bget?eco:b2374 KEGG_Orthology KO:K07749 http://www.genome.jp/dbget-bin/www_bget?KO:K07749 OMA KFDIPCA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KFDIPCA PDB 1PQY http://www.ebi.ac.uk/pdbe-srv/view/entry/1PQY PDB 1PT5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1PT5 PDB 1PT7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1PT7 PDB 1PT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1PT8 PDB 1Q6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q6Y PDB 1Q7E http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q7E PDBsum 1PQY http://www.ebi.ac.uk/pdbsum/1PQY PDBsum 1PT5 http://www.ebi.ac.uk/pdbsum/1PT5 PDBsum 1PT7 http://www.ebi.ac.uk/pdbsum/1PT7 PDBsum 1PT8 http://www.ebi.ac.uk/pdbsum/1PT8 PDBsum 1Q6Y http://www.ebi.ac.uk/pdbsum/1Q6Y PDBsum 1Q7E http://www.ebi.ac.uk/pdbsum/1Q7E PSORT swissprot:FCTA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FCTA_ECOLI PSORT-B swissprot:FCTA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FCTA_ECOLI PSORT2 swissprot:FCTA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FCTA_ECOLI Pfam PF02515 http://pfam.xfam.org/family/PF02515 Phobius swissprot:FCTA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FCTA_ECOLI PhylomeDB P69902 http://phylomedb.org/?seqid=P69902 ProteinModelPortal P69902 http://www.proteinmodelportal.org/query/uniprot/P69902 PubMed 12694615 http://www.ncbi.nlm.nih.gov/pubmed/12694615 PubMed 12844490 http://www.ncbi.nlm.nih.gov/pubmed/12844490 PubMed 14993676 http://www.ncbi.nlm.nih.gov/pubmed/14993676 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18245280 http://www.ncbi.nlm.nih.gov/pubmed/18245280 PubMed 23335415 http://www.ncbi.nlm.nih.gov/pubmed/23335415 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416875 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416875 RefSeq WP_000106759 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000106759 SMR P69902 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69902 STRING 511145.b2374 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2374&targetmode=cogs STRING COG1804 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1804&targetmode=cogs SUPFAM SSF89796 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF89796 TIGRFAMs TIGR03253 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03253 UniProtKB FCTA_ECOLI http://www.uniprot.org/uniprot/FCTA_ECOLI UniProtKB-AC P69902 http://www.uniprot.org/uniprot/P69902 charge swissprot:FCTA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FCTA_ECOLI eggNOG COG1804 http://eggnogapi.embl.de/nog_data/html/tree/COG1804 eggNOG ENOG4105C04 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C04 epestfind swissprot:FCTA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FCTA_ECOLI garnier swissprot:FCTA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FCTA_ECOLI helixturnhelix swissprot:FCTA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FCTA_ECOLI hmoment swissprot:FCTA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FCTA_ECOLI iep swissprot:FCTA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FCTA_ECOLI inforesidue swissprot:FCTA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FCTA_ECOLI octanol swissprot:FCTA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FCTA_ECOLI pepcoil swissprot:FCTA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FCTA_ECOLI pepdigest swissprot:FCTA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FCTA_ECOLI pepinfo swissprot:FCTA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FCTA_ECOLI pepnet swissprot:FCTA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FCTA_ECOLI pepstats swissprot:FCTA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FCTA_ECOLI pepwheel swissprot:FCTA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FCTA_ECOLI pepwindow swissprot:FCTA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FCTA_ECOLI sigcleave swissprot:FCTA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FCTA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260375 237 # CATALYTIC ACTIVITY CHER_ECOLI S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate methyl ester. # EcoGene EG10148 cheR # FUNCTION CHER_ECOLI Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_function GO:0008983 protein-glutamate O-methyltransferase activity; IEA:UniProtKB-EC. # GO_process GO:0006935 chemotaxis; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0040011 locomotion # Gene3D 1.10.155.10 -; 1. # Gene3D 3.40.50.150 -; 1. # IntAct P07364 16 # InterPro IPR000780 CheR_MeTrfase # InterPro IPR022641 CheR_N # InterPro IPR022642 CheR_C # InterPro IPR026024 Chemotaxis_MeTrfase_CheR # InterPro IPR029063 SAM-dependent_MTases # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Pathway ko02020 Two-component system # KEGG_Pathway ko02030 Bacterial chemotaxis # Organism CHER_ECOLI Escherichia coli (strain K12) # PATRIC 32119095 VBIEscCol129921_1965 # PIR D64951 XYECCR # PIRSF PIRSF000410 CheR # PRINTS PR00996 CHERMTFRASE # PROSITE PS50123 CHER # Pfam PF01739 CheR # Pfam PF03705 CheR_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CHER_ECOLI Chemotaxis protein methyltransferase # RefSeq NP_416398 NC_000913.3 # RefSeq WP_000204337 NZ_LN832404.1 # SIMILARITY Contains 1 cheR-type methyltransferase domain. {ECO:0000255|PROSITE-ProRule PRU00051}. # SMART SM00138 MeTrc # SUPFAM SSF47757 SSF47757 # SUPFAM SSF53335 SSF53335 # eggNOG ENOG4105BZU Bacteria # eggNOG ENOG410XNMH LUCA BLAST swissprot:CHER_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CHER_ECOLI BioCyc ECOL316407:JW1873-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1873-MONOMER BioCyc EcoCyc:CHER-MONOMER http://biocyc.org/getid?id=EcoCyc:CHER-MONOMER BioCyc MetaCyc:CHER-MONOMER http://biocyc.org/getid?id=MetaCyc:CHER-MONOMER COG COG1352 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1352 DIP DIP-9273N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9273N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.1.80 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.80 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M13463 http://www.ebi.ac.uk/ena/data/view/M13463 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.1.1.80 http://enzyme.expasy.org/EC/2.1.1.80 EchoBASE EB0146 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0146 EcoGene EG10148 http://www.ecogene.org/geneInfo.php?eg_id=EG10148 EnsemblBacteria AAC74954 http://www.ensemblgenomes.org/id/AAC74954 EnsemblBacteria AAC74954 http://www.ensemblgenomes.org/id/AAC74954 EnsemblBacteria BAA15700 http://www.ensemblgenomes.org/id/BAA15700 EnsemblBacteria BAA15700 http://www.ensemblgenomes.org/id/BAA15700 EnsemblBacteria BAA15700 http://www.ensemblgenomes.org/id/BAA15700 EnsemblBacteria b1884 http://www.ensemblgenomes.org/id/b1884 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0008983 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008983 GO_process GO:0006935 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006935 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0040011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011 Gene3D 1.10.155.10 http://www.cathdb.info/version/latest/superfamily/1.10.155.10 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 GeneID 946396 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946396 HOGENOM HOG000254353 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000254353&db=HOGENOM6 InParanoid P07364 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P07364 IntAct P07364 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P07364* IntEnz 2.1.1.80 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.80 InterPro IPR000780 http://www.ebi.ac.uk/interpro/entry/IPR000780 InterPro IPR022641 http://www.ebi.ac.uk/interpro/entry/IPR022641 InterPro IPR022642 http://www.ebi.ac.uk/interpro/entry/IPR022642 InterPro IPR026024 http://www.ebi.ac.uk/interpro/entry/IPR026024 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW1873 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1873 KEGG_Gene eco:b1884 http://www.genome.jp/dbget-bin/www_bget?eco:b1884 KEGG_Orthology KO:K00575 http://www.genome.jp/dbget-bin/www_bget?KO:K00575 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 KEGG_Pathway ko02030 http://www.genome.jp/kegg-bin/show_pathway?ko02030 OMA FVGHAEN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FVGHAEN PRINTS PR00996 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00996 PROSITE PS50123 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50123 PSORT swissprot:CHER_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CHER_ECOLI PSORT-B swissprot:CHER_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CHER_ECOLI PSORT2 swissprot:CHER_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CHER_ECOLI Pfam PF01739 http://pfam.xfam.org/family/PF01739 Pfam PF03705 http://pfam.xfam.org/family/PF03705 Phobius swissprot:CHER_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CHER_ECOLI PhylomeDB P07364 http://phylomedb.org/?seqid=P07364 ProteinModelPortal P07364 http://www.proteinmodelportal.org/query/uniprot/P07364 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3510184 http://www.ncbi.nlm.nih.gov/pubmed/3510184 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416398 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416398 RefSeq WP_000204337 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000204337 SMART SM00138 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00138 SMR P07364 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P07364 STRING 511145.b1884 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1884&targetmode=cogs STRING COG1352 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1352&targetmode=cogs SUPFAM SSF47757 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47757 SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 UniProtKB CHER_ECOLI http://www.uniprot.org/uniprot/CHER_ECOLI UniProtKB-AC P07364 http://www.uniprot.org/uniprot/P07364 charge swissprot:CHER_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CHER_ECOLI eggNOG ENOG4105BZU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZU eggNOG ENOG410XNMH http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNMH epestfind swissprot:CHER_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CHER_ECOLI garnier swissprot:CHER_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CHER_ECOLI helixturnhelix swissprot:CHER_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CHER_ECOLI hmoment swissprot:CHER_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CHER_ECOLI iep swissprot:CHER_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CHER_ECOLI inforesidue swissprot:CHER_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CHER_ECOLI octanol swissprot:CHER_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CHER_ECOLI pepcoil swissprot:CHER_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CHER_ECOLI pepdigest swissprot:CHER_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CHER_ECOLI pepinfo swissprot:CHER_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CHER_ECOLI pepnet swissprot:CHER_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CHER_ECOLI pepstats swissprot:CHER_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CHER_ECOLI pepwheel swissprot:CHER_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CHER_ECOLI pepwindow swissprot:CHER_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CHER_ECOLI sigcleave swissprot:CHER_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CHER_ECOLI ## Database ID URL or Descriptions # AltName ATP-dependent NAD kinase {ECO:0000255|HAMAP-Rule MF_00361} # BIOPHYSICOCHEMICAL PROPERTIES NADK_ECOLI Kinetic parameters KM=2 mM for NAD (at pH 7 and 37 degrees Celsius) {ECO 0000269|PubMed 11488932, ECO 0000269|PubMed 15855156, ECO 0000269|PubMed 3025169}; KM=2.5 mM for ATP (at pH 7 and 37 degrees Celsius) {ECO 0000269|PubMed 11488932, ECO 0000269|PubMed 15855156, ECO 0000269|PubMed 3025169}; KM=4.1 mM for magnesium (at pH 7 and 37 degrees Celsius) {ECO 0000269|PubMed 11488932, ECO 0000269|PubMed 15855156, ECO 0000269|PubMed 3025169}; Vmax=12.86 umol/min/mg enzyme (at pH 7 and 37 degrees Celsius) {ECO 0000269|PubMed 11488932, ECO 0000269|PubMed 15855156, ECO 0000269|PubMed 3025169}; Note=Kcat is 55 sec(-1) for kinase activity with ATP. Kcat is 125 sec(-1) for kinase activity with NAD.; pH dependence Optimum pH is between 7.2 and 7.5. {ECO 0000269|PubMed 11488932, ECO 0000269|PubMed 15855156, ECO 0000269|PubMed 3025169}; Temperature dependence Optimum temperature is 60 degrees Celsius and half of the activity is lost on treatment at 65 degrees Celsius for 10 minutes. {ECO 0000269|PubMed 11488932, ECO 0000269|PubMed 15855156, ECO 0000269|PubMed 3025169}; # BRENDA 2.7.1.23 2026 # BioGrid 4260607 19 # BioGrid 851428 4 # CATALYTIC ACTIVITY NADK_ECOLI ATP + NAD(+) = ADP + NADP(+). {ECO 0000255|HAMAP-Rule MF_00361, ECO 0000269|PubMed 11488932, ECO 0000269|PubMed 15855156, ECO 0000269|PubMed 3025169}. # COFACTOR NADK_ECOLI Name=a divalent metal cation; Xref=ChEBI CHEBI 60240; Evidence={ECO 0000255|HAMAP-Rule MF_00361, ECO 0000269|PubMed 11488932}; # ENZYME REGULATION NADK_ECOLI Competitively and allosterically inhibited by NADH and NADPH at physiological concentrations, whereas inhibition by NADP is only slight. Inhibited by p-chloromercuribenzoate and HgCl(2). {ECO 0000269|PubMed 11488932, ECO 0000269|PubMed 3025169}. # EcoGene EG12192 nadK # FUNCTION NADK_ECOLI Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. It can use ATP and other nucleoside triphosphates (UTP, CTP, GTP, dATP, TTP) as phosphoryl donors, while nucleoside mono- or diphosphates and poly(P) can not. {ECO 0000255|HAMAP-Rule MF_00361, ECO 0000269|PubMed 11488932, ECO 0000269|PubMed 15855156, ECO 0000269|PubMed 3025169}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003951 NAD+ kinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IDA:UniProtKB. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0051287 NAD binding; IDA:UniProtKB. # GO_process GO:0006741 NADP biosynthetic process; IDA:EcoCyc. # GO_process GO:0019674 NAD metabolic process; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 2.60.200.30 -; 1. # Gene3D 3.40.50.10330 -; 1. # HAMAP MF_00361 NAD_kinase # IntAct P0A7B3 3 # InterPro IPR002504 NADK # InterPro IPR016064 NAD/diacylglycerol_kinase # InterPro IPR017437 ATP-NAD_kinase_PpnK-typ_all-b # InterPro IPR017438 ATP-NAD_kinase_dom_1 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00760 Nicotinate and nicotinamide metabolism # Organism NADK_ECOLI Escherichia coli (strain K12) # PATRIC 32120629 VBIEscCol129921_2713 # PIR B65040 B65040 # Pfam PF01513 NAD_kinase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NAD kinase {ECO:0000255|HAMAP-Rule MF_00361} # RefSeq NP_417105 NC_000913.3 # RefSeq WP_001059169 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=X07863; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=Y00357; Type=Frameshift; Positions=204, 215, 282; Evidence={ECO 0000305}; # SIMILARITY Belongs to the NAD kinase family. {ECO:0000255|HAMAP- Rule MF_00361}. # SUBCELLULAR LOCATION NADK_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00361}. # SUBUNIT Homohexamer. {ECO:0000269|PubMed 11488932}. # SUPFAM SSF111331 SSF111331 # eggNOG COG0061 LUCA # eggNOG ENOG4105F91 Bacteria BLAST swissprot:NADK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NADK_ECOLI BioCyc ECOL316407:JW2596-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2596-MONOMER BioCyc EcoCyc:MONOMER0-541 http://biocyc.org/getid?id=EcoCyc:MONOMER0-541 BioCyc MetaCyc:MONOMER0-541 http://biocyc.org/getid?id=MetaCyc:MONOMER0-541 COG COG0061 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0061 DIP DIP-48103N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48103N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1432-1327.2001.02358.x http://dx.doi.org/10.1046/j.1432-1327.2001.02358.x DOI 10.1074/jbc.M502518200 http://dx.doi.org/10.1074/jbc.M502518200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/nar/15.13.5041 http://dx.doi.org/10.1093/nar/15.13.5041 DOI 10.1093/nar/16.15.7545 http://dx.doi.org/10.1093/nar/16.15.7545 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.23 {ECO:0000255|HAMAP-Rule:MF_00361} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.23 {ECO:0000255|HAMAP-Rule:MF_00361} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36840 http://www.ebi.ac.uk/ena/data/view/U36840 EMBL X07863 http://www.ebi.ac.uk/ena/data/view/X07863 EMBL Y00357 http://www.ebi.ac.uk/ena/data/view/Y00357 ENZYME 2.7.1.23 {ECO:0000255|HAMAP-Rule:MF_00361} http://enzyme.expasy.org/EC/2.7.1.23 {ECO:0000255|HAMAP-Rule:MF_00361} EchoBASE EB2109 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2109 EcoGene EG12192 http://www.ecogene.org/geneInfo.php?eg_id=EG12192 EnsemblBacteria AAC75664 http://www.ensemblgenomes.org/id/AAC75664 EnsemblBacteria AAC75664 http://www.ensemblgenomes.org/id/AAC75664 EnsemblBacteria BAA16500 http://www.ensemblgenomes.org/id/BAA16500 EnsemblBacteria BAA16500 http://www.ensemblgenomes.org/id/BAA16500 EnsemblBacteria BAA16500 http://www.ensemblgenomes.org/id/BAA16500 EnsemblBacteria b2615 http://www.ensemblgenomes.org/id/b2615 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003951 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003951 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051287 GO_process GO:0006741 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006741 GO_process GO:0019674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019674 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 2.60.200.30 http://www.cathdb.info/version/latest/superfamily/2.60.200.30 Gene3D 3.40.50.10330 http://www.cathdb.info/version/latest/superfamily/3.40.50.10330 GeneID 947092 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947092 HAMAP MF_00361 http://hamap.expasy.org/unirule/MF_00361 HOGENOM HOG000227221 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000227221&db=HOGENOM6 InParanoid P0A7B3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7B3 IntAct P0A7B3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7B3* IntEnz 2.7.1.23 {ECO:0000255|HAMAP-Rule:MF_00361} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.23 {ECO:0000255|HAMAP-Rule:MF_00361} InterPro IPR002504 http://www.ebi.ac.uk/interpro/entry/IPR002504 InterPro IPR016064 http://www.ebi.ac.uk/interpro/entry/IPR016064 InterPro IPR017437 http://www.ebi.ac.uk/interpro/entry/IPR017437 InterPro IPR017438 http://www.ebi.ac.uk/interpro/entry/IPR017438 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2596 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2596 KEGG_Gene eco:b2615 http://www.genome.jp/dbget-bin/www_bget?eco:b2615 KEGG_Orthology KO:K00858 http://www.genome.jp/dbget-bin/www_bget?KO:K00858 KEGG_Pathway ko00760 http://www.genome.jp/kegg-bin/show_pathway?ko00760 KEGG_Reaction rn:R00104 http://www.genome.jp/dbget-bin/www_bget?rn:R00104 OMA KLHWHEY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KLHWHEY PSORT swissprot:NADK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NADK_ECOLI PSORT-B swissprot:NADK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NADK_ECOLI PSORT2 swissprot:NADK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NADK_ECOLI Pfam PF01513 http://pfam.xfam.org/family/PF01513 Phobius swissprot:NADK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NADK_ECOLI PhylomeDB P0A7B3 http://phylomedb.org/?seqid=P0A7B3 ProteinModelPortal P0A7B3 http://www.proteinmodelportal.org/query/uniprot/P0A7B3 PubMed 11488932 http://www.ncbi.nlm.nih.gov/pubmed/11488932 PubMed 15855156 http://www.ncbi.nlm.nih.gov/pubmed/15855156 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3025169 http://www.ncbi.nlm.nih.gov/pubmed/3025169 PubMed 3037486 http://www.ncbi.nlm.nih.gov/pubmed/3037486 PubMed 3045760 http://www.ncbi.nlm.nih.gov/pubmed/3045760 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417105 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417105 RefSeq WP_001059169 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001059169 SMR P0A7B3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7B3 STRING 511145.b2615 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2615&targetmode=cogs STRING COG0061 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0061&targetmode=cogs SUPFAM SSF111331 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF111331 UniProtKB NADK_ECOLI http://www.uniprot.org/uniprot/NADK_ECOLI UniProtKB-AC P0A7B3 http://www.uniprot.org/uniprot/P0A7B3 charge swissprot:NADK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NADK_ECOLI eggNOG COG0061 http://eggnogapi.embl.de/nog_data/html/tree/COG0061 eggNOG ENOG4105F91 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F91 epestfind swissprot:NADK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NADK_ECOLI garnier swissprot:NADK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NADK_ECOLI helixturnhelix swissprot:NADK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NADK_ECOLI hmoment swissprot:NADK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NADK_ECOLI iep swissprot:NADK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NADK_ECOLI inforesidue swissprot:NADK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NADK_ECOLI octanol swissprot:NADK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NADK_ECOLI pepcoil swissprot:NADK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NADK_ECOLI pepdigest swissprot:NADK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NADK_ECOLI pepinfo swissprot:NADK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NADK_ECOLI pepnet swissprot:NADK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NADK_ECOLI pepstats swissprot:NADK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NADK_ECOLI pepwheel swissprot:NADK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NADK_ECOLI pepwindow swissprot:NADK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NADK_ECOLI sigcleave swissprot:NADK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NADK_ECOLI ## Database ID URL or Descriptions # CAUTION There is no equivalent of this gene in strain K12 / MG1655. {ECO 0000305}. # FUNCTION INH13_ECOLI Involved in the transposition of the insertion sequence IS5. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # InterPro IPR002559 Transposase_11 # InterPro IPR008490 Transposase_InsH_N # Organism INH13_ECOLI Escherichia coli (strain K12) # Pfam PF01609 DDE_Tnp_1 # Pfam PF05598 DUF772 # RecName INH13_ECOLI Transposase InsH for insertion sequence element IS5-13 # RefSeq WP_000019403 NZ_LN832404.1 # SIMILARITY Belongs to the transposase 11 family. {ECO 0000305}. # eggNOG COG3039 LUCA # eggNOG ENOG4105F2I Bacteria BLAST swissprot:INH13_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INH13_ECOLI DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EnsemblBacteria BAE76355 http://www.ensemblgenomes.org/id/BAE76355 EnsemblBacteria BAE76355 http://www.ensemblgenomes.org/id/BAE76355 EnsemblBacteria BAE76355 http://www.ensemblgenomes.org/id/BAE76355 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 InterPro IPR002559 http://www.ebi.ac.uk/interpro/entry/IPR002559 InterPro IPR008490 http://www.ebi.ac.uk/interpro/entry/IPR008490 KEGG_Gene ecj:JW5895 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5895 PSORT swissprot:INH13_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INH13_ECOLI PSORT-B swissprot:INH13_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INH13_ECOLI PSORT2 swissprot:INH13_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INH13_ECOLI Pfam PF01609 http://pfam.xfam.org/family/PF01609 Pfam PF05598 http://pfam.xfam.org/family/PF05598 Phobius swissprot:INH13_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INH13_ECOLI PhylomeDB P0CE60 http://phylomedb.org/?seqid=P0CE60 ProteinModelPortal P0CE60 http://www.proteinmodelportal.org/query/uniprot/P0CE60 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 RefSeq WP_000019403 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000019403 SMR P0CE60 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0CE60 STRING 511145.b3505 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3505&targetmode=cogs UniProtKB INH13_ECOLI http://www.uniprot.org/uniprot/INH13_ECOLI UniProtKB-AC P0CE60 http://www.uniprot.org/uniprot/P0CE60 charge swissprot:INH13_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INH13_ECOLI eggNOG COG3039 http://eggnogapi.embl.de/nog_data/html/tree/COG3039 eggNOG ENOG4105F2I http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F2I epestfind swissprot:INH13_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INH13_ECOLI garnier swissprot:INH13_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INH13_ECOLI helixturnhelix swissprot:INH13_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INH13_ECOLI hmoment swissprot:INH13_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INH13_ECOLI iep swissprot:INH13_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INH13_ECOLI inforesidue swissprot:INH13_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INH13_ECOLI octanol swissprot:INH13_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INH13_ECOLI pepcoil swissprot:INH13_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INH13_ECOLI pepdigest swissprot:INH13_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INH13_ECOLI pepinfo swissprot:INH13_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INH13_ECOLI pepnet swissprot:INH13_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INH13_ECOLI pepstats swissprot:INH13_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INH13_ECOLI pepwheel swissprot:INH13_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INH13_ECOLI pepwindow swissprot:INH13_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INH13_ECOLI sigcleave swissprot:INH13_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INH13_ECOLI ## Database ID URL or Descriptions # AltName PRET_ECOLI Dihydrothymine dehydrogenase # AltName PRET_ECOLI Dihydrouracil dehydrogenase # BIOPHYSICOCHEMICAL PROPERTIES PRET_ECOLI Kinetic parameters KM=38 uM for uracil (at pH 6 and 30 degrees Celsius) {ECO 0000269|PubMed 21169495}; KM=87 uM for thymidine (at pH 6 and 30 degrees Celsius) {ECO 0000269|PubMed 21169495}; KM=130 uM for DHT (at pH 11 and 30 degrees Celsius) {ECO 0000269|PubMed 21169495}; KM=160 uM for DHU (at pH 11 and 30 degrees Celsius) {ECO 0000269|PubMed 21169495}; Vmax=0.18 umol/min/mg enzyme toward DHT (at pH 11 and 30 degrees Celsius) {ECO 0000269|PubMed 21169495}; Vmax=0.26 umol/min/mg enzyme toward thymidine (at pH 6 and 30 degrees Celsius) {ECO 0000269|PubMed 21169495}; Vmax=0.43 umol/min/mg enzyme toward uracil (at pH 6 and 30 degrees Celsius) {ECO 0000269|PubMed 21169495}; Vmax=0.44 umol/min/mg enzyme toward DHU (at pH 11 and 30 degrees Celsius) {ECO 0000269|PubMed 21169495}; # BioGrid 4259169 9 # CATALYTIC ACTIVITY PRET_ECOLI 5,6-dihydrothymine + NAD(+) = thymine + NADH. # CATALYTIC ACTIVITY PRET_ECOLI 5,6-dihydrouracil + NAD(+) = uracil + NADH. # EcoGene EG14074 preT # FUNCTION PRET_ECOLI Involved in pyrimidine base degradation. Catalyzes physiologically the reduction of uracil to 5,6-dihydrouracil (DHU) by using NADH as a specific cosubstrate. It also catalyzes the reverse reaction and the reduction of thymine to 5,6- dihydrothymine (DHT). {ECO 0000269|PubMed 18482579, ECO 0000269|PubMed 21169495}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0003954 NADH dehydrogenase activity; IDA:UniProtKB. # GO_function GO:0004159 dihydrouracil dehydrogenase (NAD+) activity; IEA:UniProtKB-EC. # GO_function GO:0051536 iron-sulfur cluster binding; IDA:EcoCyc. # GO_process GO:0006208 pyrimidine nucleobase catabolic process; IDA:UniProtKB. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.720 -; 1. # Gene3D 3.50.50.60 -; 2. # INDUCTION Transcriptionally regulated by IscS. {ECO:0000269|PubMed 18482579}. # IntAct P76440 5 # InterPro IPR009051 Helical_ferredxn # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR023753 FAD/NAD-binding_dom # InterPro IPR028261 DPD_II # Organism PRET_ECOLI Escherichia coli (strain K12) # PATRIC 32119635 VBIEscCol129921_2228 # PIR A64983 A64983 # Pfam PF07992 Pyr_redox_2 # Pfam PF14691 Fer4_20 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PRET_ECOLI NAD-dependent dihydropyrimidine dehydrogenase subunit PreT # RefSeq NP_416651 NC_000913.3 # RefSeq WP_001136389 NZ_LN832404.1 # SIMILARITY Belongs to the NADH dehydrogenase family. {ECO 0000305}. # SUBUNIT Heterotetramer of 2 PreA and 2 PreT subunits. {ECO:0000269|PubMed 21169495}. # SUPFAM SSF46548 SSF46548 # eggNOG COG0493 LUCA # eggNOG ENOG4105BZ8 Bacteria BLAST swissprot:PRET_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PRET_ECOLI BioCyc ECOL316407:JW2133-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2133-MONOMER BioCyc EcoCyc:G7145-MONOMER http://biocyc.org/getid?id=EcoCyc:G7145-MONOMER BioCyc MetaCyc:G7145-MONOMER http://biocyc.org/getid?id=MetaCyc:G7145-MONOMER DIP DIP-28055N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-28055N DOI 10.1016/j.bbrc.2008.05.019 http://dx.doi.org/10.1016/j.bbrc.2008.05.019 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01178-10 http://dx.doi.org/10.1128/JB.01178-10 EC_number EC:1.3.1.1 http://www.genome.jp/dbget-bin/www_bget?EC:1.3.1.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.3.1.1 http://enzyme.expasy.org/EC/1.3.1.1 EchoBASE EB3827 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3827 EcoGene EG14074 http://www.ecogene.org/geneInfo.php?eg_id=EG14074 EnsemblBacteria AAC75207 http://www.ensemblgenomes.org/id/AAC75207 EnsemblBacteria AAC75207 http://www.ensemblgenomes.org/id/AAC75207 EnsemblBacteria BAE76623 http://www.ensemblgenomes.org/id/BAE76623 EnsemblBacteria BAE76623 http://www.ensemblgenomes.org/id/BAE76623 EnsemblBacteria BAE76623 http://www.ensemblgenomes.org/id/BAE76623 EnsemblBacteria b2146 http://www.ensemblgenomes.org/id/b2146 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003954 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003954 GO_function GO:0004159 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004159 GO_function GO:0051536 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051536 GO_process GO:0006208 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006208 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 GeneID 949049 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949049 HOGENOM HOG000031439 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000031439&db=HOGENOM6 InParanoid P76440 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76440 IntAct P76440 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76440* IntEnz 1.3.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.3.1.1 InterPro IPR009051 http://www.ebi.ac.uk/interpro/entry/IPR009051 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 InterPro IPR028261 http://www.ebi.ac.uk/interpro/entry/IPR028261 KEGG_Gene ecj:JW2133 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2133 KEGG_Gene eco:b2146 http://www.genome.jp/dbget-bin/www_bget?eco:b2146 OMA RNTINTQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RNTINTQ PSORT swissprot:PRET_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PRET_ECOLI PSORT-B swissprot:PRET_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PRET_ECOLI PSORT2 swissprot:PRET_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PRET_ECOLI Pfam PF07992 http://pfam.xfam.org/family/PF07992 Pfam PF14691 http://pfam.xfam.org/family/PF14691 Phobius swissprot:PRET_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PRET_ECOLI PhylomeDB P76440 http://phylomedb.org/?seqid=P76440 ProteinModelPortal P76440 http://www.proteinmodelportal.org/query/uniprot/P76440 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18482579 http://www.ncbi.nlm.nih.gov/pubmed/18482579 PubMed 21169495 http://www.ncbi.nlm.nih.gov/pubmed/21169495 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416651 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416651 RefSeq WP_001136389 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001136389 SMR P76440 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76440 STRING 511145.b2146 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2146&targetmode=cogs SUPFAM SSF46548 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46548 UniProtKB PRET_ECOLI http://www.uniprot.org/uniprot/PRET_ECOLI UniProtKB-AC P76440 http://www.uniprot.org/uniprot/P76440 charge swissprot:PRET_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PRET_ECOLI eggNOG COG0493 http://eggnogapi.embl.de/nog_data/html/tree/COG0493 eggNOG ENOG4105BZ8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZ8 epestfind swissprot:PRET_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PRET_ECOLI garnier swissprot:PRET_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PRET_ECOLI helixturnhelix swissprot:PRET_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PRET_ECOLI hmoment swissprot:PRET_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PRET_ECOLI iep swissprot:PRET_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PRET_ECOLI inforesidue swissprot:PRET_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PRET_ECOLI octanol swissprot:PRET_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PRET_ECOLI pepcoil swissprot:PRET_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PRET_ECOLI pepdigest swissprot:PRET_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PRET_ECOLI pepinfo swissprot:PRET_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PRET_ECOLI pepnet swissprot:PRET_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PRET_ECOLI pepstats swissprot:PRET_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PRET_ECOLI pepwheel swissprot:PRET_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PRET_ECOLI pepwindow swissprot:PRET_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PRET_ECOLI sigcleave swissprot:PRET_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PRET_ECOLI ## Database ID URL or Descriptions # BioGrid 4263250 115 # EcoGene EG13363 ydaU # InterPro IPR010781 DUF1376 # Organism YDAU_ECOLI Escherichia coli (strain K12) # PATRIC 32117996 VBIEscCol129921_1418 # PIR B64886 B64886 # Pfam PF07120 DUF1376 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDAU_ECOLI Uncharacterized protein YdaU # RefSeq NP_415877 NC_000913.3 # RefSeq WP_000899748 NZ_CP014272.1 # eggNOG COG3756 LUCA # eggNOG ENOG4105ZTP Bacteria BLAST swissprot:YDAU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDAU_ECOLI BioCyc ECOL316407:JW1354-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1354-MONOMER BioCyc EcoCyc:G6683-MONOMER http://biocyc.org/getid?id=EcoCyc:G6683-MONOMER DIP DIP-11628N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11628N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3146 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3146 EcoGene EG13363 http://www.ecogene.org/geneInfo.php?eg_id=EG13363 EnsemblBacteria AAC74441 http://www.ensemblgenomes.org/id/AAC74441 EnsemblBacteria AAC74441 http://www.ensemblgenomes.org/id/AAC74441 EnsemblBacteria BAE76414 http://www.ensemblgenomes.org/id/BAE76414 EnsemblBacteria BAE76414 http://www.ensemblgenomes.org/id/BAE76414 EnsemblBacteria BAE76414 http://www.ensemblgenomes.org/id/BAE76414 EnsemblBacteria b1359 http://www.ensemblgenomes.org/id/b1359 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945925 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945925 HOGENOM HOG000123379 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000123379&db=HOGENOM6 InterPro IPR010781 http://www.ebi.ac.uk/interpro/entry/IPR010781 KEGG_Gene ecj:JW1354 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1354 KEGG_Gene eco:b1359 http://www.genome.jp/dbget-bin/www_bget?eco:b1359 OMA FRINTRA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FRINTRA PSORT swissprot:YDAU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDAU_ECOLI PSORT-B swissprot:YDAU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDAU_ECOLI PSORT2 swissprot:YDAU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDAU_ECOLI Pfam PF07120 http://pfam.xfam.org/family/PF07120 Phobius swissprot:YDAU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDAU_ECOLI ProteinModelPortal P76065 http://www.proteinmodelportal.org/query/uniprot/P76065 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415877 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415877 RefSeq WP_000899748 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000899748 STRING 511145.b1359 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1359&targetmode=cogs UniProtKB YDAU_ECOLI http://www.uniprot.org/uniprot/YDAU_ECOLI UniProtKB-AC P76065 http://www.uniprot.org/uniprot/P76065 charge swissprot:YDAU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDAU_ECOLI eggNOG COG3756 http://eggnogapi.embl.de/nog_data/html/tree/COG3756 eggNOG ENOG4105ZTP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ZTP epestfind swissprot:YDAU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDAU_ECOLI garnier swissprot:YDAU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDAU_ECOLI helixturnhelix swissprot:YDAU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDAU_ECOLI hmoment swissprot:YDAU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDAU_ECOLI iep swissprot:YDAU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDAU_ECOLI inforesidue swissprot:YDAU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDAU_ECOLI octanol swissprot:YDAU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDAU_ECOLI pepcoil swissprot:YDAU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDAU_ECOLI pepdigest swissprot:YDAU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDAU_ECOLI pepinfo swissprot:YDAU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDAU_ECOLI pepnet swissprot:YDAU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDAU_ECOLI pepstats swissprot:YDAU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDAU_ECOLI pepwheel swissprot:YDAU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDAU_ECOLI pepwindow swissprot:YDAU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDAU_ECOLI sigcleave swissprot:YDAU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDAU_ECOLI ## Database ID URL or Descriptions # EcoGene EG14142 yfdT # Organism YFDT_ECOLI Escherichia coli (strain K12) # PATRIC 32120103 VBIEscCol129921_2460 # PIR H65009 H65009 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFDT_ECOLI Uncharacterized protein YfdT # RefSeq NP_416864 NC_000913.3 # RefSeq WP_000206809 NZ_LN832404.1 BLAST swissprot:YFDT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFDT_ECOLI BioCyc ECOL316407:JW5887-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5887-MONOMER BioCyc EcoCyc:G7232-MONOMER http://biocyc.org/getid?id=EcoCyc:G7232-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3894 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3894 EcoGene EG14142 http://www.ecogene.org/geneInfo.php?eg_id=EG14142 EnsemblBacteria AAC75422 http://www.ensemblgenomes.org/id/AAC75422 EnsemblBacteria AAC75422 http://www.ensemblgenomes.org/id/AAC75422 EnsemblBacteria BAE76702 http://www.ensemblgenomes.org/id/BAE76702 EnsemblBacteria BAE76702 http://www.ensemblgenomes.org/id/BAE76702 EnsemblBacteria BAE76702 http://www.ensemblgenomes.org/id/BAE76702 EnsemblBacteria b2363 http://www.ensemblgenomes.org/id/b2363 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946836 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946836 HOGENOM HOG000054849 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000054849&db=HOGENOM6 KEGG_Gene ecj:JW5887 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5887 KEGG_Gene eco:b2363 http://www.genome.jp/dbget-bin/www_bget?eco:b2363 OMA DKEYMAW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DKEYMAW PSORT swissprot:YFDT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFDT_ECOLI PSORT-B swissprot:YFDT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFDT_ECOLI PSORT2 swissprot:YFDT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFDT_ECOLI Phobius swissprot:YFDT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFDT_ECOLI ProteinModelPortal P76516 http://www.proteinmodelportal.org/query/uniprot/P76516 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416864 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416864 RefSeq WP_000206809 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000206809 STRING 511145.b2363 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2363&targetmode=cogs UniProtKB YFDT_ECOLI http://www.uniprot.org/uniprot/YFDT_ECOLI UniProtKB-AC P76516 http://www.uniprot.org/uniprot/P76516 charge swissprot:YFDT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFDT_ECOLI epestfind swissprot:YFDT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFDT_ECOLI garnier swissprot:YFDT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFDT_ECOLI helixturnhelix swissprot:YFDT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFDT_ECOLI hmoment swissprot:YFDT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFDT_ECOLI iep swissprot:YFDT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFDT_ECOLI inforesidue swissprot:YFDT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFDT_ECOLI octanol swissprot:YFDT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFDT_ECOLI pepcoil swissprot:YFDT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFDT_ECOLI pepdigest swissprot:YFDT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFDT_ECOLI pepinfo swissprot:YFDT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFDT_ECOLI pepnet swissprot:YFDT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFDT_ECOLI pepstats swissprot:YFDT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFDT_ECOLI pepwheel swissprot:YFDT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFDT_ECOLI pepwindow swissprot:YFDT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFDT_ECOLI sigcleave swissprot:YFDT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFDT_ECOLI ## Database ID URL or Descriptions # AltName YAJL_ECOLI Chaperone protein YajL # BIOPHYSICOCHEMICAL PROPERTIES YAJL_ECOLI Kinetic parameters KM=2.97 mM for glyoxal (at pH 7.4 and 37 degrees Celsius) {ECO 0000269|PubMed 26678554}; Note=kcat is 70.32 min(-1) for glyoxalase activity with glyoxal as substrate (at pH 7.4 and 37 degrees Celsius) (PubMed 26678554). The apparent kcat of methylglyoxal and glyoxal degradation is 0.08 sec(-1), and 0.15 sec(-1), respectively (at 22 degrees Celsius) (PubMed 26774339). {ECO 0000269|PubMed 26678554, ECO 0000269|PubMed 26774339}; # BioGrid 4263345 4 # BioGrid 849455 57 # CAUTION Was originally (Ref.1) thought to be involved in thiamine biosynthesis. However, this phenotype was probably due to an artifactual recombination event involving a portion of the adjacent thiI gene. {ECO 0000305}. # DISRUPTION PHENOTYPE YAJL_ECOLI Cells lacking this gene display highest sensitivity to carbonyl stress. The yajL mutant (but not the parental strain) suffers from a 100-fold decrease in viability after incubation for 48 h in LB medium containing 0.6% glucose, and the mutant is rescued by YajL- and DJ-1-overproducing plasmids. The wild-type strain displays a small quantity of glycated proteins after overnight culture in LB medium supplemented with 0.6% glucose, whereas the yajL mutant displays much higher levels of glycated proteins (PubMed 25416785, PubMed 26774339). Moreover, the double and triple mutants lacking yhbO and yajL, and yhbO, yajL and hchA, respectively, display impressive amounts of glycated proteins, suggesting that the YhbO, YajL and Hsp31 deglycases display relatively redundant functions (PubMed 26774339). The yajL mutant cells display decreased viability in methylglyoxal- or glucose-containing media (PubMed 26774339). They also display increased protein sulfenic acids levels, both before and after oxidative stress, but similar protein disulfides levels (PubMed 22321799). In aerobiosis, mutants show a protein aggregation phenotype, which is increased by oxidative stress (PubMed 20124404). Mutants show also altered gene expression and display decreased translation accuracy (PubMed 20889753). The yajL deletion mutant shows a negligible NADH dehydrogenase 1 activity and compensates for this low activity by utilizing NADH-independent alternative dehydrogenases, including pyruvate oxidase PoxB and D-aminoacid dehydrogenase DadA, and mixed acid aerobic fermentations characterized by acetate, lactate, succinate and ethanol excretion (PubMed 26377309). It shows up-regulation of genes involved in glycolytic and pentose phosphate pathways and alternative respiratory pathways (PubMed 26377309). Moreover, the yajL mutant preferentially catabolizes pyruvate-forming amino acids over Krebs cycle-related ones, and thus it utilizes pyruvate-centred respiro- fermentative metabolism to compensate for the NADH dehydrogenase 1 defect (PubMed 26377309). {ECO 0000269|PubMed 20124404, ECO 0000269|PubMed 20889753, ECO 0000269|PubMed 22321799, ECO 0000269|PubMed 25416785, ECO 0000269|PubMed 26377309, ECO 0000269|PubMed 26774339}. # ENZYME REGULATION YAJL_ECOLI Glyoxalase activity is inhibited by zinc ions (PubMed 26678554). Active as a chaperone in both its reduced and oxidized states, and is more active in its oxidized form (PubMed 20124404). {ECO 0000269|PubMed 20124404, ECO 0000269|PubMed 26678554}. # EcoGene EG13272 yajL # FUNCTION YAJL_ECOLI Protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Is able to repair glycated serum albumin, collagen, glyceraldehyde-3-phosphate dehydrogenase, and fructose biphosphate aldolase. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of Schiff bases and advanced glycation endproducts (AGE) (PubMed 25416785, PubMed 26774339). Displays a covalent chaperone activity with sulfenylated thiol proteins by forming mixed disulfides with members of the thiol proteome, and preferentially with sulfenylated cellular proteins, upon oxidative stress; these mixed disulfides can be subsequently reduced by low- molecular-weight thiols to regenerate YajL and reduced proteins (PubMed 22157000, PubMed 22321799). Involved in biogenesis of ribosomal proteins, probably as a ribosomal protein-folding chaperone (PubMed 20889753). Confers resistance to oxidative stress (PubMed 20124404, PubMed 22157000, PubMed 22321799). Plays an important role in protection against electrophile/carbonyl stress (PubMed 26774339). The chaperone activity reported for YajL is probably recruited to execute its deglycase activity, to interact with non-native glycated proteins and gain access to partially buried glycated sites (PubMed 25416785, PubMed 26774339). Also displays an apparent glyoxalase activity that in fact reflects its deglycase activity (PubMed 26774339, PubMed 26678554). {ECO 0000269|PubMed 20124404, ECO 0000269|PubMed 20889753, ECO 0000269|PubMed 22157000, ECO 0000269|PubMed 22321799, ECO 0000269|PubMed 25416785, ECO 0000269|PubMed 26678554, ECO 0000269|PubMed 26774339}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003713 transcription coactivator activity; IBA:GO_Central. # GO_function GO:0016787 hydrolase activity; IEA:UniProtKB-KW. # GO_function GO:0019172 glyoxalase III activity; IBA:GO_Central. # GO_function GO:0036524 protein deglycase activity; IEA:InterPro. # GO_process GO:0006357 regulation of transcription from RNA polymerase II promoter; IBA:GO_Central. # GO_process GO:0009408 response to heat; IMP:EcoCyc. # GO_process GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione; IBA:GO_Central. # GO_process GO:0034599 cellular response to oxidative stress; IMP:UniProtKB. # GO_process GO:0042026 protein refolding; IMP:UniProtKB. # GO_process GO:0042254 ribosome biogenesis; IMP:UniProtKB. # GO_process GO:0070301 cellular response to hydrogen peroxide; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0000988 transcription factor activity, protein binding # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0006457 protein folding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0042254 ribosome biogenesis # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.880 -; 1. # IntAct Q46948 17 # InterPro IPR002818 DJ-1/PfpI # InterPro IPR006287 DJ1 # InterPro IPR029062 Class_I_gatase-like # KEGG_Brite ko01002 Peptidases # Organism YAJL_ECOLI Escherichia coli (strain K12) # PATRIC 32115999 VBIEscCol129921_0441 # PDB 2AB0 X-ray; 1.10 A; A/B=1-196 # PIR H64771 H64771 # PTM YAJL_ECOLI Cys-106 is easily oxidized to sulfinic acid. {ECO 0000269|PubMed 16181642}. # Pfam PF01965 DJ-1_PfpI # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Protein deglycase 3 {ECO:0000303|PubMed 26774339} # RefSeq NP_414958 NC_000913.3 # RefSeq WP_001276305 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA82704.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAB40180.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the peptidase C56 family. {ECO 0000305}. # SUBUNIT YAJL_ECOLI Homodimer. {ECO 0000269|PubMed 16181642, ECO 0000269|PubMed 22157000}. # SUPFAM SSF52317 SSF52317 # TIGRFAMs TIGR01383 not_thiJ # eggNOG COG0693 LUCA # eggNOG ENOG4107S0N Bacteria BLAST swissprot:YAJL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAJL_ECOLI BioCyc ECOL316407:JW5057-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5057-MONOMER BioCyc EcoCyc:HMP-KIN-MONOMER http://biocyc.org/getid?id=EcoCyc:HMP-KIN-MONOMER BioCyc MetaCyc:HMP-KIN-MONOMER http://biocyc.org/getid?id=MetaCyc:HMP-KIN-MONOMER COG COG0693 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0693 DOI 10.1016/j.bbrc.2016.01.068 http://dx.doi.org/10.1016/j.bbrc.2016.01.068 DOI 10.1016/j.jmb.2005.08.033 http://dx.doi.org/10.1016/j.jmb.2005.08.033 DOI 10.1016/j.jmb.2012.01.047 http://dx.doi.org/10.1016/j.jmb.2012.01.047 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M109.077529 http://dx.doi.org/10.1074/jbc.M109.077529 DOI 10.1074/jbc.M111.299198 http://dx.doi.org/10.1074/jbc.M111.299198 DOI 10.1074/jbc.M114.597815 http://dx.doi.org/10.1074/jbc.M114.597815 DOI 10.1093/femsle/fnv239 http://dx.doi.org/10.1093/femsle/fnv239 DOI 10.1093/nar/26.11.2606 http://dx.doi.org/10.1093/nar/26.11.2606 DOI 10.1099/mic.0.000181 http://dx.doi.org/10.1099/mic.0.000181 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01077-10 http://dx.doi.org/10.1128/JB.01077-10 EC_number EC:3.1.2.- {ECO:0000305|PubMed:26774339} http://www.genome.jp/dbget-bin/www_bget?EC:3.1.2.- {ECO:0000305|PubMed:26774339} EC_number EC:3.5.1.- {ECO:0000305|PubMed:26774339} http://www.genome.jp/dbget-bin/www_bget?EC:3.5.1.- {ECO:0000305|PubMed:26774339} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U34923 http://www.ebi.ac.uk/ena/data/view/U34923 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 ENZYME 3.1.2.- {ECO:0000305|PubMed:26774339} http://enzyme.expasy.org/EC/3.1.2.- {ECO:0000305|PubMed:26774339} ENZYME 3.5.1.- {ECO:0000305|PubMed:26774339} http://enzyme.expasy.org/EC/3.5.1.- {ECO:0000305|PubMed:26774339} EchoBASE EB3057 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3057 EcoGene EG13272 http://www.ecogene.org/geneInfo.php?eg_id=EG13272 EnsemblBacteria AAC73527 http://www.ensemblgenomes.org/id/AAC73527 EnsemblBacteria AAC73527 http://www.ensemblgenomes.org/id/AAC73527 EnsemblBacteria BAE76204 http://www.ensemblgenomes.org/id/BAE76204 EnsemblBacteria BAE76204 http://www.ensemblgenomes.org/id/BAE76204 EnsemblBacteria BAE76204 http://www.ensemblgenomes.org/id/BAE76204 EnsemblBacteria b0424 http://www.ensemblgenomes.org/id/b0424 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003713 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003713 GO_function GO:0016787 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016787 GO_function GO:0019172 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019172 GO_function GO:0036524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036524 GO_process GO:0006357 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006357 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GO_process GO:0019243 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019243 GO_process GO:0034599 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034599 GO_process GO:0042026 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042026 GO_process GO:0042254 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042254 GO_process GO:0070301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070301 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0000988 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000988 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0042254 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042254 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.880 http://www.cathdb.info/version/latest/superfamily/3.40.50.880 GeneID 945066 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945066 HOGENOM HOG000063194 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000063194&db=HOGENOM6 InParanoid Q46948 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46948 IntAct Q46948 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46948* IntEnz 3.1.2.- {ECO:0000305|PubMed:26774339} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.2.- {ECO:0000305|PubMed:26774339} IntEnz 3.5.1.- {ECO:0000305|PubMed:26774339} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.1.- {ECO:0000305|PubMed:26774339} InterPro IPR002818 http://www.ebi.ac.uk/interpro/entry/IPR002818 InterPro IPR006287 http://www.ebi.ac.uk/interpro/entry/IPR006287 InterPro IPR029062 http://www.ebi.ac.uk/interpro/entry/IPR029062 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW5057 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5057 KEGG_Gene eco:b0424 http://www.genome.jp/dbget-bin/www_bget?eco:b0424 KEGG_Orthology KO:K03152 http://www.genome.jp/dbget-bin/www_bget?KO:K03152 OMA AICAAPY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AICAAPY PDB 2AB0 http://www.ebi.ac.uk/pdbe-srv/view/entry/2AB0 PDBsum 2AB0 http://www.ebi.ac.uk/pdbsum/2AB0 PSORT swissprot:YAJL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAJL_ECOLI PSORT-B swissprot:YAJL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAJL_ECOLI PSORT2 swissprot:YAJL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAJL_ECOLI Pfam PF01965 http://pfam.xfam.org/family/PF01965 Phobius swissprot:YAJL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAJL_ECOLI PhylomeDB Q46948 http://phylomedb.org/?seqid=Q46948 ProteinModelPortal Q46948 http://www.proteinmodelportal.org/query/uniprot/Q46948 PubMed 16181642 http://www.ncbi.nlm.nih.gov/pubmed/16181642 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20124404 http://www.ncbi.nlm.nih.gov/pubmed/20124404 PubMed 20889753 http://www.ncbi.nlm.nih.gov/pubmed/20889753 PubMed 22157000 http://www.ncbi.nlm.nih.gov/pubmed/22157000 PubMed 22321799 http://www.ncbi.nlm.nih.gov/pubmed/22321799 PubMed 25416785 http://www.ncbi.nlm.nih.gov/pubmed/25416785 PubMed 26377309 http://www.ncbi.nlm.nih.gov/pubmed/26377309 PubMed 26678554 http://www.ncbi.nlm.nih.gov/pubmed/26678554 PubMed 26774339 http://www.ncbi.nlm.nih.gov/pubmed/26774339 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9592144 http://www.ncbi.nlm.nih.gov/pubmed/9592144 RefSeq NP_414958 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414958 RefSeq WP_001276305 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001276305 SMR Q46948 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46948 STRING 511145.b0424 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0424&targetmode=cogs STRING COG0693 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0693&targetmode=cogs SUPFAM SSF52317 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52317 TIGRFAMs TIGR01383 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01383 UniProtKB YAJL_ECOLI http://www.uniprot.org/uniprot/YAJL_ECOLI UniProtKB-AC Q46948 http://www.uniprot.org/uniprot/Q46948 charge swissprot:YAJL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAJL_ECOLI eggNOG COG0693 http://eggnogapi.embl.de/nog_data/html/tree/COG0693 eggNOG ENOG4107S0N http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107S0N epestfind swissprot:YAJL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAJL_ECOLI garnier swissprot:YAJL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAJL_ECOLI helixturnhelix swissprot:YAJL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAJL_ECOLI hmoment swissprot:YAJL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAJL_ECOLI iep swissprot:YAJL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAJL_ECOLI inforesidue swissprot:YAJL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAJL_ECOLI octanol swissprot:YAJL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAJL_ECOLI pepcoil swissprot:YAJL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAJL_ECOLI pepdigest swissprot:YAJL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAJL_ECOLI pepinfo swissprot:YAJL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAJL_ECOLI pepnet swissprot:YAJL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAJL_ECOLI pepstats swissprot:YAJL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAJL_ECOLI pepwheel swissprot:YAJL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAJL_ECOLI pepwindow swissprot:YAJL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAJL_ECOLI sigcleave swissprot:YAJL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAJL_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=0.7 mM for phosphatidylglycerol; Vmax=29.7 nmol/min/mg enzyme; pH dependence Optimum pH is 7.5. Active from pH 5 to 9.; # BioGrid 4261758 16 # COFACTOR YEGS_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 17351295}; Name=Ca(2+); Xref=ChEBI CHEBI 29108; Evidence={ECO 0000269|PubMed 17351295}; Note=Binds 1 Mg(2+) ion per subunit. Ca(2+) may be able to substitute. {ECO 0000269|PubMed 17351295}; # EcoGene EG14367 yegS # FUNCTION YEGS_ECOLI In vitro phosphorylates phosphatidylglycerol but not diacylglycerol; the in vivo substrate is unknown. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0001727 lipid kinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_process GO:0008654 phospholipid biosynthetic process; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # HAMAP MF_01377 YegS # INTERACTION YEGS_ECOLI P0ABH7 gltA; NbExp=2; IntAct=EBI-1127478, EBI-547808; # IntAct P76407 8 # InterPro IPR001206 Diacylglycerol_kinase_cat_dom # InterPro IPR005218 Diacylglycerol/lipid_kinase # InterPro IPR016064 NAD/diacylglycerol_kinase # InterPro IPR022433 Lip_kinase_YegS # Organism YEGS_ECOLI Escherichia coli (strain K12) # PATRIC 32119505 VBIEscCol129921_2163 # PDB 2BON X-ray; 1.90 A; A/B=1-299 # PDB 2JGR X-ray; 2.65 A; A=1-299 # PIR E64975 E64975 # PROSITE PS50146 DAGK # Pfam PF00781 DAGK_cat # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEGS_ECOLI Lipid kinase YegS # RefSeq NP_416590 NC_000913.3 # RefSeq WP_000807348 NZ_LN832404.1 # SIMILARITY Belongs to the diacylglycerol/lipid kinase family. YegS lipid kinase subfamily. {ECO 0000305}. # SIMILARITY Contains 1 DAGKc domain. {ECO 0000305}. # SMART SM00046 DAGKc # SUBCELLULAR LOCATION YEGS_ECOLI Cytoplasm {ECO 0000269|PubMed 17351295}. # SUBUNIT YEGS_ECOLI Monomer. {ECO 0000269|PubMed 16511327, ECO 0000269|PubMed 17351295}. # SUPFAM SSF111331 SSF111331 # TIGRFAMs TIGR00147 TIGR00147 # TIGRFAMs TIGR03702 lip_kinase_YegS # eggNOG COG1597 LUCA # eggNOG ENOG4107TE5 Bacteria BLAST swissprot:YEGS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEGS_ECOLI BioCyc ECOL316407:JW2070-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2070-MONOMER BioCyc EcoCyc:G7123-MONOMER http://biocyc.org/getid?id=EcoCyc:G7123-MONOMER BioCyc MetaCyc:G7123-MONOMER http://biocyc.org/getid?id=MetaCyc:G7123-MONOMER COG COG1597 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1597 DIP DIP-11889N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11889N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M604852200 http://dx.doi.org/10.1074/jbc.M604852200 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1107/S1744309106004799 http://dx.doi.org/10.1107/S1744309106004799 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.- http://enzyme.expasy.org/EC/2.7.1.- EchoBASE EB4111 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4111 EcoGene EG14367 http://www.ecogene.org/geneInfo.php?eg_id=EG14367 EnsemblBacteria AAC75147 http://www.ensemblgenomes.org/id/AAC75147 EnsemblBacteria AAC75147 http://www.ensemblgenomes.org/id/AAC75147 EnsemblBacteria BAA15939 http://www.ensemblgenomes.org/id/BAA15939 EnsemblBacteria BAA15939 http://www.ensemblgenomes.org/id/BAA15939 EnsemblBacteria BAA15939 http://www.ensemblgenomes.org/id/BAA15939 EnsemblBacteria b2086 http://www.ensemblgenomes.org/id/b2086 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0001727 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001727 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0008654 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008654 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 946626 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946626 HAMAP MF_01377 http://hamap.expasy.org/unirule/MF_01377 HOGENOM HOG000261396 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261396&db=HOGENOM6 InParanoid P76407 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76407 IntAct P76407 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76407* IntEnz 2.7.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1 InterPro IPR001206 http://www.ebi.ac.uk/interpro/entry/IPR001206 InterPro IPR005218 http://www.ebi.ac.uk/interpro/entry/IPR005218 InterPro IPR016064 http://www.ebi.ac.uk/interpro/entry/IPR016064 InterPro IPR022433 http://www.ebi.ac.uk/interpro/entry/IPR022433 KEGG_Gene ecj:JW2070 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2070 KEGG_Gene eco:b2086 http://www.genome.jp/dbget-bin/www_bget?eco:b2086 KEGG_Orthology KO:K07029 http://www.genome.jp/dbget-bin/www_bget?KO:K07029 OMA HWQGDLL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HWQGDLL PDB 2BON http://www.ebi.ac.uk/pdbe-srv/view/entry/2BON PDB 2JGR http://www.ebi.ac.uk/pdbe-srv/view/entry/2JGR PDBsum 2BON http://www.ebi.ac.uk/pdbsum/2BON PDBsum 2JGR http://www.ebi.ac.uk/pdbsum/2JGR PROSITE PS50146 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50146 PSORT swissprot:YEGS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEGS_ECOLI PSORT-B swissprot:YEGS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEGS_ECOLI PSORT2 swissprot:YEGS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEGS_ECOLI Pfam PF00781 http://pfam.xfam.org/family/PF00781 Phobius swissprot:YEGS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEGS_ECOLI PhylomeDB P76407 http://phylomedb.org/?seqid=P76407 ProteinModelPortal P76407 http://www.proteinmodelportal.org/query/uniprot/P76407 PubMed 16511327 http://www.ncbi.nlm.nih.gov/pubmed/16511327 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17351295 http://www.ncbi.nlm.nih.gov/pubmed/17351295 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416590 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416590 RefSeq WP_000807348 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000807348 SMART SM00046 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00046 SMR P76407 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76407 STRING 511145.b2086 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2086&targetmode=cogs STRING COG1597 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1597&targetmode=cogs SUPFAM SSF111331 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF111331 TIGRFAMs TIGR00147 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00147 TIGRFAMs TIGR03702 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03702 UniProtKB YEGS_ECOLI http://www.uniprot.org/uniprot/YEGS_ECOLI UniProtKB-AC P76407 http://www.uniprot.org/uniprot/P76407 charge swissprot:YEGS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEGS_ECOLI eggNOG COG1597 http://eggnogapi.embl.de/nog_data/html/tree/COG1597 eggNOG ENOG4107TE5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107TE5 epestfind swissprot:YEGS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEGS_ECOLI garnier swissprot:YEGS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEGS_ECOLI helixturnhelix swissprot:YEGS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEGS_ECOLI hmoment swissprot:YEGS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEGS_ECOLI iep swissprot:YEGS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEGS_ECOLI inforesidue swissprot:YEGS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEGS_ECOLI octanol swissprot:YEGS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEGS_ECOLI pepcoil swissprot:YEGS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEGS_ECOLI pepdigest swissprot:YEGS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEGS_ECOLI pepinfo swissprot:YEGS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEGS_ECOLI pepnet swissprot:YEGS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEGS_ECOLI pepstats swissprot:YEGS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEGS_ECOLI pepwheel swissprot:YEGS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEGS_ECOLI pepwindow swissprot:YEGS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEGS_ECOLI sigcleave swissprot:YEGS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEGS_ECOLI ## Database ID URL or Descriptions # AltName CHO_ECOLI Endonuclease cho # AltName CHO_ECOLI UvrC homolog protein # BioGrid 4261591 124 # EcoGene EG13993 cho # FUNCTION CHO_ECOLI Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. In vitro, the incision activity of Cho is UvrA and UvrB dependent. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair. {ECO 0000269|PubMed 11818552}. # GO_component GO:0009380 excinuclease repair complex; IBA:GO_Central. # GO_function GO:0004518 nuclease activity; IEA:UniProtKB-KW. # GO_process GO:0006281 DNA repair; IEA:UniProtKB-KW. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0009432 SOS response; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0004518 nuclease activity # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # INDUCTION CHO_ECOLI Repressed by LexA. # INTERACTION CHO_ECOLI P0A6F5 groL; NbExp=2; IntAct=EBI-545155, EBI-543750; # IntAct P76213 7 # InterPro IPR000305 GIY-YIG_SF # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # Organism CHO_ECOLI Escherichia coli (strain K12) # PATRIC 32118791 VBIEscCol129921_1813 # PIR E64933 E64933 # PROSITE PS50164 GIY_YIG # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CHO_ECOLI Excinuclease cho # RefSeq NP_416255 NC_000913.3 # RefSeq WP_000252397 NZ_LN832404.1 # SIMILARITY Contains 1 GIY-YIG domain. {ECO:0000255|PROSITE- ProRule PRU00977}. # SIMILARITY Contains 1 uvrC C-terminal domain. {ECO 0000305}. # SMART SM00465 GIYc # SUPFAM SSF82771 SSF82771 # eggNOG COG0322 LUCA # eggNOG ENOG4105DKD Bacteria BLAST swissprot:CHO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CHO_ECOLI BioCyc ECOL316407:JW1730-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1730-MONOMER BioCyc EcoCyc:G6937-MONOMER http://biocyc.org/getid?id=EcoCyc:G6937-MONOMER COG COG0322 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0322 DIP DIP-28067N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-28067N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.032584099 http://dx.doi.org/10.1073/pnas.032584099 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.25.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.25.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.25.- http://enzyme.expasy.org/EC/3.1.25.- EchoBASE EB3749 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3749 EcoGene EG13993 http://www.ecogene.org/geneInfo.php?eg_id=EG13993 EnsemblBacteria AAC74811 http://www.ensemblgenomes.org/id/AAC74811 EnsemblBacteria AAC74811 http://www.ensemblgenomes.org/id/AAC74811 EnsemblBacteria BAE76514 http://www.ensemblgenomes.org/id/BAE76514 EnsemblBacteria BAE76514 http://www.ensemblgenomes.org/id/BAE76514 EnsemblBacteria BAE76514 http://www.ensemblgenomes.org/id/BAE76514 EnsemblBacteria b1741 http://www.ensemblgenomes.org/id/b1741 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009380 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009380 GO_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GO_process GO:0006281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006281 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0009432 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009432 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 948996 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948996 HOGENOM HOG000121086 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000121086&db=HOGENOM6 IntAct P76213 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76213* IntEnz 3.1.25 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.25 InterPro IPR000305 http://www.ebi.ac.uk/interpro/entry/IPR000305 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW1730 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1730 KEGG_Gene eco:b1741 http://www.genome.jp/dbget-bin/www_bget?eco:b1741 KEGG_Orthology KO:K05984 http://www.genome.jp/dbget-bin/www_bget?KO:K05984 OMA GRCAGAC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GRCAGAC PROSITE PS50164 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50164 PSORT swissprot:CHO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CHO_ECOLI PSORT-B swissprot:CHO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CHO_ECOLI PSORT2 swissprot:CHO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CHO_ECOLI Phobius swissprot:CHO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CHO_ECOLI PhylomeDB P76213 http://phylomedb.org/?seqid=P76213 ProteinModelPortal P76213 http://www.proteinmodelportal.org/query/uniprot/P76213 PubMed 11818552 http://www.ncbi.nlm.nih.gov/pubmed/11818552 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416255 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416255 RefSeq WP_000252397 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000252397 SMART SM00465 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00465 STRING 511145.b1741 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1741&targetmode=cogs STRING COG0322 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0322&targetmode=cogs SUPFAM SSF82771 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF82771 UniProtKB CHO_ECOLI http://www.uniprot.org/uniprot/CHO_ECOLI UniProtKB-AC P76213 http://www.uniprot.org/uniprot/P76213 charge swissprot:CHO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CHO_ECOLI eggNOG COG0322 http://eggnogapi.embl.de/nog_data/html/tree/COG0322 eggNOG ENOG4105DKD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DKD epestfind swissprot:CHO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CHO_ECOLI garnier swissprot:CHO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CHO_ECOLI helixturnhelix swissprot:CHO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CHO_ECOLI hmoment swissprot:CHO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CHO_ECOLI iep swissprot:CHO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CHO_ECOLI inforesidue swissprot:CHO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CHO_ECOLI octanol swissprot:CHO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CHO_ECOLI pepcoil swissprot:CHO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CHO_ECOLI pepdigest swissprot:CHO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CHO_ECOLI pepinfo swissprot:CHO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CHO_ECOLI pepnet swissprot:CHO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CHO_ECOLI pepstats swissprot:CHO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CHO_ECOLI pepwheel swissprot:CHO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CHO_ECOLI pepwindow swissprot:CHO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CHO_ECOLI sigcleave swissprot:CHO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CHO_ECOLI ## Database ID URL or Descriptions # BioGrid 4259795 126 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG12161 eaeH # GO_component GO:0009279 cell outer membrane; IBA:GO_Central. # GO_process GO:0007155 cell adhesion; IEA:InterPro. # GO_process GO:0009405 pathogenesis; IBA:GO_Central. # GO_process GO:0030260 entry into host cell; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0007155 cell adhesion # GOslim_process GO:0008150 biological_process # IntAct P36943 5 # InterPro IPR003535 Intimin/invasin_bac # InterPro IPR024519 IAT_beta # Organism EAEH_ECOLI Escherichia coli (strain K12) # PATRIC 48659800 VBIEscCol107702_0295 # PIR A64756 A64756 # PRINTS PR01369 INTIMIN # Pfam PF11924 IAT_beta # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EAEH_ECOLI Putative attaching and effacing protein homolog # RefSeq WP_000020224 NZ_LN832404.1 # SIMILARITY Belongs to the intimin/invasin family. {ECO 0000305}. BLAST swissprot:EAEH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EAEH_ECOLI BioCyc ECOL316407:JW0291-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0291-MONOMER BioCyc EcoCyc:EG12161-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12161-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D12594 http://www.ebi.ac.uk/ena/data/view/D12594 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB2080 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2080 EcoGene EG12161 http://www.ecogene.org/geneInfo.php?eg_id=EG12161 EnsemblBacteria BAE76082 http://www.ensemblgenomes.org/id/BAE76082 EnsemblBacteria BAE76082 http://www.ensemblgenomes.org/id/BAE76082 EnsemblBacteria BAE76082 http://www.ensemblgenomes.org/id/BAE76082 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GO_process GO:0009405 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009405 GO_process GO:0030260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030260 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 HOGENOM HOG000054880 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000054880&db=HOGENOM6 IntAct P36943 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P36943* InterPro IPR003535 http://www.ebi.ac.uk/interpro/entry/IPR003535 InterPro IPR024519 http://www.ebi.ac.uk/interpro/entry/IPR024519 KEGG_Gene ecj:JW0291 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0291 OMA EAHPANG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EAHPANG PRINTS PR01369 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01369 PSORT swissprot:EAEH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EAEH_ECOLI PSORT-B swissprot:EAEH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EAEH_ECOLI PSORT2 swissprot:EAEH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EAEH_ECOLI Pfam PF11924 http://pfam.xfam.org/family/PF11924 Phobius swissprot:EAEH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EAEH_ECOLI ProteinModelPortal P36943 http://www.proteinmodelportal.org/query/uniprot/P36943 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000020224 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000020224 SMR P36943 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P36943 STRING 316407.85674442 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85674442&targetmode=cogs UniProtKB EAEH_ECOLI http://www.uniprot.org/uniprot/EAEH_ECOLI UniProtKB-AC P36943 http://www.uniprot.org/uniprot/P36943 charge swissprot:EAEH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EAEH_ECOLI epestfind swissprot:EAEH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EAEH_ECOLI garnier swissprot:EAEH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EAEH_ECOLI helixturnhelix swissprot:EAEH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EAEH_ECOLI hmoment swissprot:EAEH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EAEH_ECOLI iep swissprot:EAEH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EAEH_ECOLI inforesidue swissprot:EAEH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EAEH_ECOLI octanol swissprot:EAEH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EAEH_ECOLI pepcoil swissprot:EAEH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EAEH_ECOLI pepdigest swissprot:EAEH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EAEH_ECOLI pepinfo swissprot:EAEH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EAEH_ECOLI pepnet swissprot:EAEH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EAEH_ECOLI pepstats swissprot:EAEH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EAEH_ECOLI pepwheel swissprot:EAEH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EAEH_ECOLI pepwindow swissprot:EAEH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EAEH_ECOLI sigcleave swissprot:EAEH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EAEH_ECOLI ## Database ID URL or Descriptions # BioGrid 4260023 6 # EcoGene EG13707 ssuA # FUNCTION SSUA_ECOLI Part of a binding-protein-dependent transport system for aliphatic sulfonates. Putative binding protein. # GO_component GO:0016020 membrane; IEA:InterPro. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_process GO:0006790 sulfur compound metabolic process; IGI:EcoliWiki. # GO_process GO:0006810 transport; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0006810 transport # InterPro IPR001638 Solute-binding_3/MltF_N # InterPro IPR010067 ABC_SsuA_sub-bd # InterPro IPR015168 SsuA/THI5 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00436 Sulfonate transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism SSUA_ECOLI Escherichia coli (strain K12) # PATRIC 32117091 VBIEscCol129921_0970 # PDB 2X26 X-ray; 1.75 A; A/B=25-319 # PIR G64833 G64833 # Pfam PF09084 NMT1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SSUA_ECOLI Putative aliphatic sulfonates-binding protein # RefSeq NP_415456 NC_000913.3 # RefSeq WP_001244308 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial solute-binding protein SsuA/TauA family. {ECO 0000305}. # SMART SM00062 PBPb # SUBCELLULAR LOCATION SSUA_ECOLI Periplasm {ECO 0000305}. # TCDB 3.A.1.17.10 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR01728 SsuA_fam # eggNOG ENOG4105GVF Bacteria # eggNOG ENOG410XQHT LUCA BLAST swissprot:SSUA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SSUA_ECOLI BioCyc ECOL316407:JW0919-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0919-MONOMER BioCyc EcoCyc:G6478-MONOMER http://biocyc.org/getid?id=EcoCyc:G6478-MONOMER BioCyc MetaCyc:G6478-MONOMER http://biocyc.org/getid?id=MetaCyc:G6478-MONOMER COG COG0715 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0715 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.274.41.29358 http://dx.doi.org/10.1074/jbc.274.41.29358 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AJ237695 http://www.ebi.ac.uk/ena/data/view/AJ237695 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3471 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3471 EcoGene EG13707 http://www.ecogene.org/geneInfo.php?eg_id=EG13707 EnsemblBacteria AAC74022 http://www.ensemblgenomes.org/id/AAC74022 EnsemblBacteria AAC74022 http://www.ensemblgenomes.org/id/AAC74022 EnsemblBacteria BAA35691 http://www.ensemblgenomes.org/id/BAA35691 EnsemblBacteria BAA35691 http://www.ensemblgenomes.org/id/BAA35691 EnsemblBacteria BAA35691 http://www.ensemblgenomes.org/id/BAA35691 EnsemblBacteria b0936 http://www.ensemblgenomes.org/id/b0936 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 945560 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945560 HOGENOM HOG000164730 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000164730&db=HOGENOM6 InParanoid P75853 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75853 InterPro IPR001638 http://www.ebi.ac.uk/interpro/entry/IPR001638 InterPro IPR010067 http://www.ebi.ac.uk/interpro/entry/IPR010067 InterPro IPR015168 http://www.ebi.ac.uk/interpro/entry/IPR015168 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0919 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0919 KEGG_Gene eco:b0936 http://www.genome.jp/dbget-bin/www_bget?eco:b0936 KEGG_Orthology KO:K15553 http://www.genome.jp/dbget-bin/www_bget?KO:K15553 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA KISWIEF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KISWIEF PDB 2X26 http://www.ebi.ac.uk/pdbe-srv/view/entry/2X26 PDBsum 2X26 http://www.ebi.ac.uk/pdbsum/2X26 PSORT swissprot:SSUA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SSUA_ECOLI PSORT-B swissprot:SSUA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SSUA_ECOLI PSORT2 swissprot:SSUA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SSUA_ECOLI Pfam PF09084 http://pfam.xfam.org/family/PF09084 Phobius swissprot:SSUA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SSUA_ECOLI PhylomeDB P75853 http://phylomedb.org/?seqid=P75853 ProteinModelPortal P75853 http://www.proteinmodelportal.org/query/uniprot/P75853 PubMed 10506196 http://www.ncbi.nlm.nih.gov/pubmed/10506196 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415456 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415456 RefSeq WP_001244308 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001244308 SMART SM00062 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00062 SMR P75853 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75853 STRING 511145.b0936 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0936&targetmode=cogs STRING COG0715 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0715&targetmode=cogs TCDB 3.A.1.17.10 http://www.tcdb.org/search/result.php?tc=3.A.1.17.10 TIGRFAMs TIGR01728 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01728 UniProtKB SSUA_ECOLI http://www.uniprot.org/uniprot/SSUA_ECOLI UniProtKB-AC P75853 http://www.uniprot.org/uniprot/P75853 charge swissprot:SSUA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SSUA_ECOLI eggNOG ENOG4105GVF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105GVF eggNOG ENOG410XQHT http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQHT epestfind swissprot:SSUA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SSUA_ECOLI garnier swissprot:SSUA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SSUA_ECOLI helixturnhelix swissprot:SSUA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SSUA_ECOLI hmoment swissprot:SSUA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SSUA_ECOLI iep swissprot:SSUA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SSUA_ECOLI inforesidue swissprot:SSUA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SSUA_ECOLI octanol swissprot:SSUA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SSUA_ECOLI pepcoil swissprot:SSUA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SSUA_ECOLI pepdigest swissprot:SSUA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SSUA_ECOLI pepinfo swissprot:SSUA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SSUA_ECOLI pepnet swissprot:SSUA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SSUA_ECOLI pepstats swissprot:SSUA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SSUA_ECOLI pepwheel swissprot:SSUA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SSUA_ECOLI pepwindow swissprot:SSUA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SSUA_ECOLI sigcleave swissprot:SSUA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SSUA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262082 69 # COFACTOR YHFW_ECOLI Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000305}; Note=Binds 1 or 2 manganese ions. {ECO 0000305}; # EcoGene EG12918 yhfW # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0000287 magnesium ion binding; IEA:InterPro. # GO_function GO:0008973 phosphopentomutase activity; IBA:GO_Central. # GO_process GO:0009117 nucleotide metabolic process; IEA:InterPro. # GO_process GO:0043094 cellular metabolic compound salvage; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.720.10 -; 2. # IntAct P45549 2 # InterPro IPR006124 Metalloenzyme # InterPro IPR010045 DeoB # InterPro IPR017849 Alkaline_Pase-like_a/b/a # InterPro IPR017850 Alkaline_phosphatase_core # Organism YHFW_ECOLI Escherichia coli (strain K12) # PATRIC 32122192 VBIEscCol129921_3473 # PIR G65132 G65132 # PIRSF PIRSF001491 Ppentomutase # Pfam PF01676 Metalloenzyme # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHFW_ECOLI Uncharacterized protein YhfW # RefSeq NP_417839 NC_000913.3 # RefSeq WP_000090644 NZ_LN832404.1 # SIMILARITY Belongs to the phosphopentomutase family. {ECO 0000305}. # SUPFAM SSF53649 SSF53649; 2 # eggNOG COG1015 LUCA # eggNOG ENOG4105CZG Bacteria BLAST swissprot:YHFW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHFW_ECOLI BioCyc ECOL316407:JW3343-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3343-MONOMER BioCyc EcoCyc:G7732-MONOMER http://biocyc.org/getid?id=EcoCyc:G7732-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2754 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2754 EcoGene EG12918 http://www.ecogene.org/geneInfo.php?eg_id=EG12918 EnsemblBacteria AAC76405 http://www.ensemblgenomes.org/id/AAC76405 EnsemblBacteria AAC76405 http://www.ensemblgenomes.org/id/AAC76405 EnsemblBacteria BAE77911 http://www.ensemblgenomes.org/id/BAE77911 EnsemblBacteria BAE77911 http://www.ensemblgenomes.org/id/BAE77911 EnsemblBacteria BAE77911 http://www.ensemblgenomes.org/id/BAE77911 EnsemblBacteria b3380 http://www.ensemblgenomes.org/id/b3380 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0008973 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008973 GO_process GO:0009117 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009117 GO_process GO:0043094 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043094 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.720.10 http://www.cathdb.info/version/latest/superfamily/3.40.720.10 GeneID 947890 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947890 HOGENOM HOG000008160 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000008160&db=HOGENOM6 InParanoid P45549 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45549 IntAct P45549 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45549* InterPro IPR006124 http://www.ebi.ac.uk/interpro/entry/IPR006124 InterPro IPR010045 http://www.ebi.ac.uk/interpro/entry/IPR010045 InterPro IPR017849 http://www.ebi.ac.uk/interpro/entry/IPR017849 InterPro IPR017850 http://www.ebi.ac.uk/interpro/entry/IPR017850 KEGG_Gene ecj:JW3343 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3343 KEGG_Gene eco:b3380 http://www.genome.jp/dbget-bin/www_bget?eco:b3380 OMA HQEIMGT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HQEIMGT PSORT swissprot:YHFW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHFW_ECOLI PSORT-B swissprot:YHFW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHFW_ECOLI PSORT2 swissprot:YHFW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHFW_ECOLI Pfam PF01676 http://pfam.xfam.org/family/PF01676 Phobius swissprot:YHFW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHFW_ECOLI PhylomeDB P45549 http://phylomedb.org/?seqid=P45549 ProteinModelPortal P45549 http://www.proteinmodelportal.org/query/uniprot/P45549 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417839 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417839 RefSeq WP_000090644 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000090644 STRING 511145.b3380 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3380&targetmode=cogs SUPFAM SSF53649 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53649 UniProtKB YHFW_ECOLI http://www.uniprot.org/uniprot/YHFW_ECOLI UniProtKB-AC P45549 http://www.uniprot.org/uniprot/P45549 charge swissprot:YHFW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHFW_ECOLI eggNOG COG1015 http://eggnogapi.embl.de/nog_data/html/tree/COG1015 eggNOG ENOG4105CZG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CZG epestfind swissprot:YHFW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHFW_ECOLI garnier swissprot:YHFW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHFW_ECOLI helixturnhelix swissprot:YHFW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHFW_ECOLI hmoment swissprot:YHFW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHFW_ECOLI iep swissprot:YHFW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHFW_ECOLI inforesidue swissprot:YHFW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHFW_ECOLI octanol swissprot:YHFW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHFW_ECOLI pepcoil swissprot:YHFW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHFW_ECOLI pepdigest swissprot:YHFW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHFW_ECOLI pepinfo swissprot:YHFW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHFW_ECOLI pepnet swissprot:YHFW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHFW_ECOLI pepstats swissprot:YHFW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHFW_ECOLI pepwheel swissprot:YHFW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHFW_ECOLI pepwindow swissprot:YHFW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHFW_ECOLI sigcleave swissprot:YHFW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHFW_ECOLI ## Database ID URL or Descriptions # BioGrid 4261151 18 # CATALYTIC ACTIVITY 6PGL_ECOLI 6-phospho-D-glucono-1,5-lactone + H(2)O = 6- phospho-D-gluconate. # EcoGene EG13231 pgl # FUNCTION 6PGL_ECOLI Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. {ECO 0000269|PubMed 15576773}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0017057 6-phosphogluconolactonase activity; IDA:EcoliWiki. # GO_process GO:0006006 glucose metabolic process; IEA:UniProtKB-HAMAP. # GO_process GO:0006098 pentose-phosphate shunt; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 2.130.10.10 -; 1. # HAMAP MF_01605 6P_gluconolactonase # IntAct P52697 5 # InterPro IPR011045 N2O_reductase_N # InterPro IPR015943 WD40/YVTN_repeat-like_dom # InterPro IPR019405 Lactonase_7-beta_prop # InterPro IPR022528 6-phosphogluconolactonase_YbhE # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00030 Pentose phosphate pathway # Organism 6PGL_ECOLI Escherichia coli (strain K12) # PATHWAY Carbohydrate degradation; pentose phosphate pathway; D- ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage) step 2/3. # PATRIC 32116735 VBIEscCol129921_0793 # PDB 1RI6 X-ray; 2.00 A; A=2-331 # PIR G64812 G64812 # Pfam PF10282 Lactonase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 6PGL_ECOLI 6-phosphogluconolactonase # RefSeq NP_415288 NC_000913.3 # RefSeq WP_000815435 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=U27192; Type=Frameshift; Positions=110; Evidence={ECO 0000305}; # SIMILARITY Belongs to the cycloisomerase 2 family. {ECO 0000305}. # SUPFAM SSF50974 SSF50974 # UniPathway UPA00115 UER00409 # eggNOG COG2706 LUCA # eggNOG ENOG4105HHQ Bacteria BLAST swissprot:6PGL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:6PGL_ECOLI BioCyc ECOL316407:JW0750-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0750-MONOMER BioCyc EcoCyc:6PGLUCONOLACT-MONOMER http://biocyc.org/getid?id=EcoCyc:6PGLUCONOLACT-MONOMER BioCyc MetaCyc:6PGLUCONOLACT-MONOMER http://biocyc.org/getid?id=MetaCyc:6PGLUCONOLACT-MONOMER COG COG2706 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2706 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.186.24.8248-8253.2004 http://dx.doi.org/10.1128/JB.186.24.8248-8253.2004 EC_number EC:3.1.1.31 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.1.31 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U27192 http://www.ebi.ac.uk/ena/data/view/U27192 ENZYME 3.1.1.31 http://enzyme.expasy.org/EC/3.1.1.31 EchoBASE EB3020 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3020 EcoGene EG13231 http://www.ecogene.org/geneInfo.php?eg_id=EG13231 EnsemblBacteria AAC73854 http://www.ensemblgenomes.org/id/AAC73854 EnsemblBacteria AAC73854 http://www.ensemblgenomes.org/id/AAC73854 EnsemblBacteria BAA35431 http://www.ensemblgenomes.org/id/BAA35431 EnsemblBacteria BAA35431 http://www.ensemblgenomes.org/id/BAA35431 EnsemblBacteria BAA35431 http://www.ensemblgenomes.org/id/BAA35431 EnsemblBacteria b0767 http://www.ensemblgenomes.org/id/b0767 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0017057 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017057 GO_process GO:0006006 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006006 GO_process GO:0006098 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006098 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 2.130.10.10 http://www.cathdb.info/version/latest/superfamily/2.130.10.10 GeneID 946398 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946398 HAMAP MF_01605 http://hamap.expasy.org/unirule/MF_01605 HOGENOM HOG000257418 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000257418&db=HOGENOM6 InParanoid P52697 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P52697 IntAct P52697 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P52697* IntEnz 3.1.1.31 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.1.31 InterPro IPR011045 http://www.ebi.ac.uk/interpro/entry/IPR011045 InterPro IPR015943 http://www.ebi.ac.uk/interpro/entry/IPR015943 InterPro IPR019405 http://www.ebi.ac.uk/interpro/entry/IPR019405 InterPro IPR022528 http://www.ebi.ac.uk/interpro/entry/IPR022528 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0750 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0750 KEGG_Gene eco:b0767 http://www.genome.jp/dbget-bin/www_bget?eco:b0767 KEGG_Orthology KO:K07404 http://www.genome.jp/dbget-bin/www_bget?KO:K07404 KEGG_Pathway ko00030 http://www.genome.jp/kegg-bin/show_pathway?ko00030 KEGG_Reaction rn:R02035 http://www.genome.jp/dbget-bin/www_bget?rn:R02035 OMA MVFHPNQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MVFHPNQ PDB 1RI6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1RI6 PDBsum 1RI6 http://www.ebi.ac.uk/pdbsum/1RI6 PSORT swissprot:6PGL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:6PGL_ECOLI PSORT-B swissprot:6PGL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:6PGL_ECOLI PSORT2 swissprot:6PGL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:6PGL_ECOLI Pfam PF10282 http://pfam.xfam.org/family/PF10282 Phobius swissprot:6PGL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:6PGL_ECOLI PhylomeDB P52697 http://phylomedb.org/?seqid=P52697 ProteinModelPortal P52697 http://www.proteinmodelportal.org/query/uniprot/P52697 PubMed 15576773 http://www.ncbi.nlm.nih.gov/pubmed/15576773 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 7665460 http://www.ncbi.nlm.nih.gov/pubmed/7665460 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415288 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415288 RefSeq WP_000815435 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000815435 SMR P52697 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P52697 STRING 511145.b0767 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0767&targetmode=cogs STRING COG2706 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2706&targetmode=cogs SUPFAM SSF50974 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50974 UniProtKB 6PGL_ECOLI http://www.uniprot.org/uniprot/6PGL_ECOLI UniProtKB-AC P52697 http://www.uniprot.org/uniprot/P52697 charge swissprot:6PGL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:6PGL_ECOLI eggNOG COG2706 http://eggnogapi.embl.de/nog_data/html/tree/COG2706 eggNOG ENOG4105HHQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105HHQ epestfind swissprot:6PGL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:6PGL_ECOLI garnier swissprot:6PGL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:6PGL_ECOLI helixturnhelix swissprot:6PGL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:6PGL_ECOLI hmoment swissprot:6PGL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:6PGL_ECOLI iep swissprot:6PGL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:6PGL_ECOLI inforesidue swissprot:6PGL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:6PGL_ECOLI octanol swissprot:6PGL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:6PGL_ECOLI pepcoil swissprot:6PGL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:6PGL_ECOLI pepdigest swissprot:6PGL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:6PGL_ECOLI pepinfo swissprot:6PGL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:6PGL_ECOLI pepnet swissprot:6PGL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:6PGL_ECOLI pepstats swissprot:6PGL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:6PGL_ECOLI pepwheel swissprot:6PGL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:6PGL_ECOLI pepwindow swissprot:6PGL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:6PGL_ECOLI sigcleave swissprot:6PGL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:6PGL_ECOLI ## Database ID URL or Descriptions # DrugBank DB00560 Tigecycline # DrugBank DB00759 Tetracycline # EcoGene EG10913 rpsN # FUNCTION RS14_ECOLI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. # GO_component GO:0022627 cytosolic small ribosomal subunit; IDA:EcoliWiki. # GO_function GO:0003735 structural constituent of ribosome; IBA:GO_Central. # GO_function GO:0019843 rRNA binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006412 translation; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_function GO:0019843 rRNA binding # GOslim_process GO:0006412 translation # HAMAP MF_00537 Ribosomal_S14_1 # IntAct P0AG59 70 # InterPro IPR001209 Ribosomal_S14 # InterPro IPR018271 Ribosomal_S14_CS # InterPro IPR023036 Ribosomal_S14_bac/plaastid # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 M00179 Ribosome, archaea # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=11449.3; Method=MALDI; Range=2-101; Evidence={ECO:0000269|PubMed 10094780}; # Organism RS14_ECOLI Escherichia coli (strain K12) # PANTHER PTHR19836 PTHR19836 # PATRIC 32122046 VBIEscCol129921_3400 # PDB 1M5G Model; -; N=42-101 # PDB 2YKR EM; 9.80 A; N=2-101 # PDB 3J9Y EM; 3.90 A; n=1-101 # PDB 3J9Z EM; 3.60 A; SN=2-101 # PDB 3JA1 EM; 3.60 A; SN=2-101 # PDB 3JBU EM; 3.64 A; N=1-101 # PDB 3JBV EM; 3.32 A; N=1-101 # PDB 3JCD EM; 3.70 A; n=1-101 # PDB 3JCE EM; 3.20 A; n=1-101 # PDB 3JCJ EM; 3.70 A; w=1-101 # PDB 3JCN EM; 4.60 A; q=1-101 # PDB 4A2I EM; 16.50 A; N=2-101 # PDB 4ADV EM; 13.50 A; N=2-101 # PDB 4U1U X-ray; 2.95 A; AN/CN=2-101 # PDB 4U1V X-ray; 3.00 A; AN/CN=2-101 # PDB 4U20 X-ray; 2.90 A; AN/CN=2-101 # PDB 4U24 X-ray; 2.90 A; AN/CN=2-101 # PDB 4U25 X-ray; 2.90 A; AN/CN=2-101 # PDB 4U26 X-ray; 2.80 A; AN/CN=2-101 # PDB 4U27 X-ray; 2.80 A; AN/CN=2-101 # PDB 4V47 EM; 12.30 A; BN=2-101 # PDB 4V48 EM; 11.50 A; BN=2-101 # PDB 4V4H X-ray; 3.46 A; AN/CN=1-101 # PDB 4V4Q X-ray; 3.46 A; AN/CN=2-101 # PDB 4V4V EM; 15.00 A; AN=41-101 # PDB 4V4W EM; 15.00 A; AN=41-101 # PDB 4V50 X-ray; 3.22 A; AN/CN=2-101 # PDB 4V52 X-ray; 3.21 A; AN/CN=2-101 # PDB 4V53 X-ray; 3.54 A; AN/CN=2-101 # PDB 4V54 X-ray; 3.30 A; AN/CN=2-101 # PDB 4V55 X-ray; 4.00 A; AN/CN=2-101 # PDB 4V56 X-ray; 3.93 A; AN/CN=2-101 # PDB 4V57 X-ray; 3.50 A; AN/CN=2-101 # PDB 4V5B X-ray; 3.74 A; BN/DN=2-101 # PDB 4V5H EM; 5.80 A; AN=2-101 # PDB 4V5Y X-ray; 4.45 A; AN/CN=2-101 # PDB 4V64 X-ray; 3.50 A; AN/CN=2-101 # PDB 4V65 EM; 9.00 A; AG=1-101 # PDB 4V66 EM; 9.00 A; AG=1-101 # PDB 4V69 EM; 6.70 A; AN=2-101 # PDB 4V6C X-ray; 3.19 A; AN/CN=1-101 # PDB 4V6D X-ray; 3.81 A; AN/CN=1-101 # PDB 4V6E X-ray; 3.71 A; AN/CN=1-101 # PDB 4V6K EM; 8.25 A; BR=1-101 # PDB 4V6L EM; 13.20 A; AR=1-101 # PDB 4V6M EM; 7.10 A; AN=2-101 # PDB 4V6N EM; 12.10 A; BQ=2-101 # PDB 4V6O EM; 14.70 A; AQ=2-101 # PDB 4V6P EM; 13.50 A; AQ=2-101 # PDB 4V6Q EM; 11.50 A; AQ=2-101 # PDB 4V6R EM; 11.50 A; AQ=2-101 # PDB 4V6S EM; 13.10 A; BP=2-101 # PDB 4V6T EM; 8.30 A; AN=2-101 # PDB 4V6V EM; 9.80 A; AN=2-101 # PDB 4V6Y EM; 12.00 A; AN=1-101 # PDB 4V6Z EM; 12.00 A; AN=1-101 # PDB 4V70 EM; 17.00 A; AN=1-101 # PDB 4V71 EM; 20.00 A; AN=1-101 # PDB 4V72 EM; 13.00 A; AN=1-101 # PDB 4V73 EM; 15.00 A; AN=1-101 # PDB 4V74 EM; 17.00 A; AN=1-101 # PDB 4V75 EM; 12.00 A; AN=1-101 # PDB 4V76 EM; 17.00 A; AN=1-101 # PDB 4V77 EM; 17.00 A; AN=1-101 # PDB 4V78 EM; 20.00 A; AN=1-101 # PDB 4V79 EM; 15.00 A; AN=1-101 # PDB 4V7A EM; 9.00 A; AN=1-101 # PDB 4V7B EM; 6.80 A; AN=1-101 # PDB 4V7C EM; 7.60 A; AN=2-101 # PDB 4V7D EM; 7.60 A; BN=2-101 # PDB 4V7I EM; 9.60 A; BN=1-101 # PDB 4V7S X-ray; 3.25 A; AN/CN=2-101 # PDB 4V7T X-ray; 3.19 A; AN/CN=2-101 # PDB 4V7U X-ray; 3.10 A; AN/CN=2-101 # PDB 4V7V X-ray; 3.29 A; AN/CN=2-101 # PDB 4V85 X-ray; 3.20 A; N=1-101 # PDB 4V89 X-ray; 3.70 A; AN=1-101 # PDB 4V9C X-ray; 3.30 A; AN/CN=1-101 # PDB 4V9D X-ray; 3.00 A; AN/BN=2-101 # PDB 4V9O X-ray; 2.90 A; BN/DN/FN/HN=1-101 # PDB 4V9P X-ray; 2.90 A; BN/DN/FN/HN=1-101 # PDB 4WF1 X-ray; 3.09 A; AN/CN=2-101 # PDB 4WOI X-ray; 3.00 A; AN/DN=1-101 # PDB 4WWW X-ray; 3.10 A; QN/XN=1-101 # PDB 4YBB X-ray; 2.10 A; AN/BN=2-101 # PDB 5AFI EM; 2.90 A; n=1-101 # PDB 5IQR EM; 3.00 A; s=1-101 # PDB 5IT8 X-ray; 3.12 A; AN/BN=2-101 # PDB 5J5B X-ray; 2.80 A; AN/BN=2-101 # PDB 5J7L X-ray; 3.00 A; AN/BN=2-101 # PDB 5J88 X-ray; 3.32 A; AN/BN=2-101 # PDB 5J8A X-ray; 3.10 A; AN/BN=2-101 # PDB 5J91 X-ray; 2.96 A; AN/BN=2-101 # PDB 5JC9 X-ray; 3.03 A; AN/BN=2-101 # PDB 5JTE EM; 3.60 A; AN=1-101 # PDB 5JU8 EM; 3.60 A; AN=1-101 # PDB 5KCR EM; 3.60 A; 1n=1-101 # PDB 5KCS EM; 3.90 A; 1n=1-101 # PDB 5KPS EM; 3.90 A; 19=1-101 # PDB 5KPV EM; 4.10 A; 18=1-101 # PDB 5KPW EM; 3.90 A; 18=1-101 # PDB 5KPX EM; 3.90 A; 18=1-101 # PDB 5L3P EM; 3.70 A; n=1-101 # PIR F65123 R3EC14 # PROSITE PS00527 RIBOSOMAL_S14 # Pfam PF00253 Ribosomal_S14 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RS14_ECOLI 30S ribosomal protein S14 # RefSeq NP_417766 NC_000913.3 # RefSeq WP_001118930 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein S14P family. {ECO 0000305}. # SUBUNIT Part of the 30S ribosomal subunit. Contacts proteins S3 and S10 (By similarity). {ECO 0000250}. # eggNOG COG0199 LUCA # eggNOG ENOG4105VBI Bacteria BLAST swissprot:RS14_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RS14_ECOLI BioCyc ECOL316407:JW3269-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3269-MONOMER BioCyc EcoCyc:EG10913-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10913-MONOMER BioCyc MetaCyc:EG10913-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10913-MONOMER COG COG0199 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0199 DIP DIP-35805N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35805N DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1016/S0092-8674(03)00427-6 http://dx.doi.org/10.1016/S0092-8674(03)00427-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb841 http://dx.doi.org/10.1038/nsb841 DOI 10.1093/nar/11.9.2599 http://dx.doi.org/10.1093/nar/11.9.2599 DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB00560 http://www.drugbank.ca/drugs/DB00560 DrugBank DB00759 http://www.drugbank.ca/drugs/DB00759 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X01563 http://www.ebi.ac.uk/ena/data/view/X01563 EchoBASE EB0906 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0906 EcoGene EG10913 http://www.ecogene.org/geneInfo.php?eg_id=EG10913 EnsemblBacteria AAC76332 http://www.ensemblgenomes.org/id/AAC76332 EnsemblBacteria AAC76332 http://www.ensemblgenomes.org/id/AAC76332 EnsemblBacteria BAE77984 http://www.ensemblgenomes.org/id/BAE77984 EnsemblBacteria BAE77984 http://www.ensemblgenomes.org/id/BAE77984 EnsemblBacteria BAE77984 http://www.ensemblgenomes.org/id/BAE77984 EnsemblBacteria b3307 http://www.ensemblgenomes.org/id/b3307 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0022627 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022627 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GeneID 947801 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947801 HAMAP MF_00537 http://hamap.expasy.org/unirule/MF_00537 HOGENOM HOG000039864 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000039864&db=HOGENOM6 InParanoid P0AG59 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AG59 IntAct P0AG59 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AG59* InterPro IPR001209 http://www.ebi.ac.uk/interpro/entry/IPR001209 InterPro IPR018271 http://www.ebi.ac.uk/interpro/entry/IPR018271 InterPro IPR023036 http://www.ebi.ac.uk/interpro/entry/IPR023036 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW3269 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3269 KEGG_Gene eco:b3307 http://www.genome.jp/dbget-bin/www_bget?eco:b3307 KEGG_Orthology KO:K02954 http://www.genome.jp/dbget-bin/www_bget?KO:K02954 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 MINT MINT-1295909 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1295909 OMA GVYSKFG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GVYSKFG PANTHER PTHR19836 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19836 PDB 1M5G http://www.ebi.ac.uk/pdbe-srv/view/entry/1M5G PDB 2YKR http://www.ebi.ac.uk/pdbe-srv/view/entry/2YKR PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 4A2I http://www.ebi.ac.uk/pdbe-srv/view/entry/4A2I PDB 4ADV http://www.ebi.ac.uk/pdbe-srv/view/entry/4ADV PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4V47 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V47 PDB 4V48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V48 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 1M5G http://www.ebi.ac.uk/pdbsum/1M5G PDBsum 2YKR http://www.ebi.ac.uk/pdbsum/2YKR PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 4A2I http://www.ebi.ac.uk/pdbsum/4A2I PDBsum 4ADV http://www.ebi.ac.uk/pdbsum/4ADV PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4V47 http://www.ebi.ac.uk/pdbsum/4V47 PDBsum 4V48 http://www.ebi.ac.uk/pdbsum/4V48 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PROSITE PS00527 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00527 PSORT swissprot:RS14_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RS14_ECOLI PSORT-B swissprot:RS14_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RS14_ECOLI PSORT2 swissprot:RS14_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RS14_ECOLI Pfam PF00253 http://pfam.xfam.org/family/PF00253 Phobius swissprot:RS14_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RS14_ECOLI PhylomeDB P0AG59 http://phylomedb.org/?seqid=P0AG59 ProteinModelPortal P0AG59 http://www.proteinmodelportal.org/query/uniprot/P0AG59 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 12244297 http://www.ncbi.nlm.nih.gov/pubmed/12244297 PubMed 12809609 http://www.ncbi.nlm.nih.gov/pubmed/12809609 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6222285 http://www.ncbi.nlm.nih.gov/pubmed/6222285 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417766 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417766 RefSeq WP_001118930 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001118930 SMR P0AG59 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AG59 STRING 511145.b3307 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3307&targetmode=cogs STRING COG0199 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0199&targetmode=cogs UniProtKB RS14_ECOLI http://www.uniprot.org/uniprot/RS14_ECOLI UniProtKB-AC P0AG59 http://www.uniprot.org/uniprot/P0AG59 charge swissprot:RS14_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RS14_ECOLI eggNOG COG0199 http://eggnogapi.embl.de/nog_data/html/tree/COG0199 eggNOG ENOG4105VBI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VBI epestfind swissprot:RS14_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RS14_ECOLI garnier swissprot:RS14_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RS14_ECOLI helixturnhelix swissprot:RS14_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RS14_ECOLI hmoment swissprot:RS14_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RS14_ECOLI iep swissprot:RS14_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RS14_ECOLI inforesidue swissprot:RS14_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RS14_ECOLI octanol swissprot:RS14_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RS14_ECOLI pepcoil swissprot:RS14_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RS14_ECOLI pepdigest swissprot:RS14_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RS14_ECOLI pepinfo swissprot:RS14_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RS14_ECOLI pepnet swissprot:RS14_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RS14_ECOLI pepstats swissprot:RS14_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RS14_ECOLI pepwheel swissprot:RS14_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RS14_ECOLI pepwindow swissprot:RS14_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RS14_ECOLI sigcleave swissprot:RS14_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RS14_ECOLI ## Database ID URL or Descriptions # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0000746 conjugation; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0008150 biological_process # InterPro IPR016386 Plasmid_mob_TrbF # Organism TRBF_ECOLI Escherichia coli (strain K12) # PIR JS0124 BVECTF # PIRSF PIRSF003271 Plasmib_mob_TrbF # RecName TRBF_ECOLI Protein TrbF # RefSeq NP_061476 NC_002483.1 # RefSeq WP_001366201 NZ_CP014273.1 # SUBCELLULAR LOCATION TRBF_ECOLI Cell inner membrane {ECO 0000305}; Multi- pass membrane protein {ECO 0000305}. BLAST swissprot:TRBF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRBF_ECOLI DOI 10.1016/0378-1119(89)90392-2 http://dx.doi.org/10.1016/0378-1119(89)90392-2 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL M20787 http://www.ebi.ac.uk/ena/data/view/M20787 EMBL M24492 http://www.ebi.ac.uk/ena/data/view/M24492 EMBL M59763 http://www.ebi.ac.uk/ena/data/view/M59763 EMBL U01159 http://www.ebi.ac.uk/ena/data/view/U01159 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0000746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000746 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 1263555 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263555 InterPro IPR016386 http://www.ebi.ac.uk/interpro/entry/IPR016386 OMA GNNDASH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GNNDASH PSORT swissprot:TRBF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRBF_ECOLI PSORT-B swissprot:TRBF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRBF_ECOLI PSORT2 swissprot:TRBF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRBF_ECOLI Phobius swissprot:TRBF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRBF_ECOLI ProteinModelPortal P15068 http://www.proteinmodelportal.org/query/uniprot/P15068 PubMed 2536655 http://www.ncbi.nlm.nih.gov/pubmed/2536655 PubMed 2656408 http://www.ncbi.nlm.nih.gov/pubmed/2656408 PubMed 7915817 http://www.ncbi.nlm.nih.gov/pubmed/7915817 RefSeq NP_061476 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061476 RefSeq WP_001366201 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001366201 UniProtKB TRBF_ECOLI http://www.uniprot.org/uniprot/TRBF_ECOLI UniProtKB-AC P15068 http://www.uniprot.org/uniprot/P15068 charge swissprot:TRBF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRBF_ECOLI epestfind swissprot:TRBF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRBF_ECOLI garnier swissprot:TRBF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRBF_ECOLI helixturnhelix swissprot:TRBF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRBF_ECOLI hmoment swissprot:TRBF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRBF_ECOLI iep swissprot:TRBF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRBF_ECOLI inforesidue swissprot:TRBF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRBF_ECOLI octanol swissprot:TRBF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRBF_ECOLI pepcoil swissprot:TRBF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRBF_ECOLI pepdigest swissprot:TRBF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRBF_ECOLI pepinfo swissprot:TRBF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRBF_ECOLI pepnet swissprot:TRBF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRBF_ECOLI pepstats swissprot:TRBF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRBF_ECOLI pepwheel swissprot:TRBF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRBF_ECOLI pepwindow swissprot:TRBF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRBF_ECOLI sigcleave swissprot:TRBF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRBF_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES LGOD_ECOLI Kinetic parameters KM=19.5 mM for L-galactonate {ECO 0000269|PubMed 24861318}; Vmax=0.8 umol/min/mg enzyme {ECO 0000269|PubMed 24861318}; Note=kcat is 0.51 sec(-1) with L-galactonate. {ECO 0000269|PubMed 24861318}; pH dependence Optimum pH is 8.0. {ECO 0000269|PubMed 24861318}; # BioGrid 4261389 9 # CATALYTIC ACTIVITY L-galactonate + NAD(+) = D-tagaturonate + NADH. {ECO:0000269|PubMed 24861318}. # COFACTOR LGOD_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000250}; Note=Binds 2 Zn(2+) ions per subunit. {ECO 0000250}; # DISRUPTION PHENOTYPE Cells lacking this gene fail to grow on L- galactonate as sole carbon source. {ECO:0000269|PubMed 17088549}. # ENZYME REGULATION Inhibited by EDTA. {ECO:0000269|PubMed 24861318}. # EcoGene EG12590 lgoD # FUNCTION LGOD_ECOLI Catalyzes the oxidation of L-galactonate to D- tagaturonate. Required for growth on L-galactonate as the sole carbon source. In vitro, can also use L-gulonate. {ECO 0000269|PubMed 17088549, ECO 0000269|PubMed 24861318}. # GO_function GO:0008270 zinc ion binding; IEA:InterPro. # GO_function GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IDA:EcoCyc. # GO_process GO:0034195 L-galactonate catabolic process; IMP:EcoCyc. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.720 -; 1. # Gene3D 3.90.180.10 -; 1. # INDUCTION Highly up-regulated during growth on L-galactonate. {ECO:0000269|PubMed 17088549}. # InterPro IPR002085 ADH_SF_Zn-type # InterPro IPR002328 ADH_Zn_CS # InterPro IPR011032 GroES-like # InterPro IPR013149 ADH_C # InterPro IPR013154 ADH_N # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR020843 PKS_ER # Organism LGOD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11695 PTHR11695 # PATRIC 32124324 VBIEscCol129921_4505 # PIR S56585 S56585 # PROSITE PS00059 ADH_ZINC # Pfam PF00107 ADH_zinc_N # Pfam PF08240 ADH_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName L-galactonate-5-dehydrogenase {ECO:0000303|PubMed 24861318} # RefSeq NP_418778 NC_000913.3 # RefSeq WP_000106030 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97256.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the zinc-containing alcohol dehydrogenase family. {ECO 0000305}. # SMART SM00829 PKS_ER # SUPFAM SSF50129 SSF50129 # SUPFAM SSF51735 SSF51735 # eggNOG COG1063 LUCA # eggNOG ENOG4105CPQ Bacteria BLAST swissprot:LGOD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LGOD_ECOLI BioCyc ECOL316407:JW5793-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5793-MONOMER BioCyc EcoCyc:G7945-MONOMER http://biocyc.org/getid?id=EcoCyc:G7945-MONOMER BioCyc MetaCyc:G7945-MONOMER http://biocyc.org/getid?id=MetaCyc:G7945-MONOMER DOI 10.1007/s12010-014-0969-0 http://dx.doi.org/10.1007/s12010-014-0969-0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0603364103 http://dx.doi.org/10.1073/pnas.0603364103 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.- {ECO:0000269|PubMed:24861318} http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.- {ECO:0000269|PubMed:24861318} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 1.1.1.- {ECO:0000269|PubMed:24861318} http://enzyme.expasy.org/EC/1.1.1.- {ECO:0000269|PubMed:24861318} EchoBASE EB2475 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2475 EcoGene EG12590 http://www.ecogene.org/geneInfo.php?eg_id=EG12590 EnsemblBacteria AAC77314 http://www.ensemblgenomes.org/id/AAC77314 EnsemblBacteria AAC77314 http://www.ensemblgenomes.org/id/AAC77314 EnsemblBacteria BAE78348 http://www.ensemblgenomes.org/id/BAE78348 EnsemblBacteria BAE78348 http://www.ensemblgenomes.org/id/BAE78348 EnsemblBacteria BAE78348 http://www.ensemblgenomes.org/id/BAE78348 EnsemblBacteria b4358 http://www.ensemblgenomes.org/id/b4358 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0016616 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016616 GO_process GO:0034195 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034195 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 Gene3D 3.90.180.10 http://www.cathdb.info/version/latest/superfamily/3.90.180.10 GeneID 948883 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948883 HOGENOM HOG000294690 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000294690&db=HOGENOM6 InParanoid P39400 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39400 IntEnz 1.1.1.- {ECO:0000269|PubMed:24861318} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.- {ECO:0000269|PubMed:24861318} InterPro IPR002085 http://www.ebi.ac.uk/interpro/entry/IPR002085 InterPro IPR002328 http://www.ebi.ac.uk/interpro/entry/IPR002328 InterPro IPR011032 http://www.ebi.ac.uk/interpro/entry/IPR011032 InterPro IPR013149 http://www.ebi.ac.uk/interpro/entry/IPR013149 InterPro IPR013154 http://www.ebi.ac.uk/interpro/entry/IPR013154 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR020843 http://www.ebi.ac.uk/interpro/entry/IPR020843 KEGG_Gene ecj:JW5793 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5793 KEGG_Gene eco:b4358 http://www.genome.jp/dbget-bin/www_bget?eco:b4358 PANTHER PTHR11695 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11695 PROSITE PS00059 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00059 PSORT swissprot:LGOD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LGOD_ECOLI PSORT-B swissprot:LGOD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LGOD_ECOLI PSORT2 swissprot:LGOD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LGOD_ECOLI Pfam PF00107 http://pfam.xfam.org/family/PF00107 Pfam PF08240 http://pfam.xfam.org/family/PF08240 Phobius swissprot:LGOD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LGOD_ECOLI PhylomeDB P39400 http://phylomedb.org/?seqid=P39400 ProteinModelPortal P39400 http://www.proteinmodelportal.org/query/uniprot/P39400 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17088549 http://www.ncbi.nlm.nih.gov/pubmed/17088549 PubMed 24861318 http://www.ncbi.nlm.nih.gov/pubmed/24861318 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418778 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418778 RefSeq WP_000106030 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000106030 SMART SM00829 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00829 SMR P39400 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39400 STRING 511145.b4358 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4358&targetmode=cogs SUPFAM SSF50129 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50129 SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB LGOD_ECOLI http://www.uniprot.org/uniprot/LGOD_ECOLI UniProtKB-AC P39400 http://www.uniprot.org/uniprot/P39400 charge swissprot:LGOD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LGOD_ECOLI eggNOG COG1063 http://eggnogapi.embl.de/nog_data/html/tree/COG1063 eggNOG ENOG4105CPQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CPQ epestfind swissprot:LGOD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LGOD_ECOLI garnier swissprot:LGOD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LGOD_ECOLI helixturnhelix swissprot:LGOD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LGOD_ECOLI hmoment swissprot:LGOD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LGOD_ECOLI iep swissprot:LGOD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LGOD_ECOLI inforesidue swissprot:LGOD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LGOD_ECOLI octanol swissprot:LGOD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LGOD_ECOLI pepcoil swissprot:LGOD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LGOD_ECOLI pepdigest swissprot:LGOD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LGOD_ECOLI pepinfo swissprot:LGOD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LGOD_ECOLI pepnet swissprot:LGOD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LGOD_ECOLI pepstats swissprot:LGOD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LGOD_ECOLI pepwheel swissprot:LGOD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LGOD_ECOLI pepwindow swissprot:LGOD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LGOD_ECOLI sigcleave swissprot:LGOD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LGOD_ECOLI ## Database ID URL or Descriptions # AltName PFLF_ECOLI Pyruvate formate-lyase 3 # CATALYTIC ACTIVITY PFLF_ECOLI Acetyl-CoA + formate = CoA + pyruvate. # EcoGene EG13328 ybiW # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008861 formate C-acetyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016407 acetyltransferase activity; IBA:GO_Central. # GO_process GO:0005975 carbohydrate metabolic process; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0005975 carbohydrate metabolic process # IntAct P75793 6 # InterPro IPR001150 Gly_radical # InterPro IPR004184 PFL_dom # InterPro IPR005949 Form_AcTrfase # InterPro IPR010098 PFL2/GDeHydtase_fam # InterPro IPR019777 Form_AcTrfase_GR_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00620 Pyruvate metabolism # KEGG_Pathway ko00640 Propanoate metabolism # KEGG_Pathway ko00650 Butanoate metabolism # Organism PFLF_ECOLI Escherichia coli (strain K12) # PATHWAY Fermentation; pyruvate fermentation; formate from pyruvate step 1/1. # PATRIC 32116849 VBIEscCol129921_0850 # PIR G64819 G64819 # PIRSF PIRSF000379 For_Ac_trans_1 # PROSITE PS00850 GLY_RADICAL_1 # PROSITE PS51149 GLY_RADICAL_2 # PROSITE PS51554 PFL # Pfam PF01228 Gly_radical # Pfam PF02901 PFL-like # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PFLF_ECOLI Putative formate acetyltransferase 3 # RefSeq NP_415344 NC_000913.3 # RefSeq WP_000209309 NZ_LN832404.1 # SIMILARITY Contains 1 PFL domain. {ECO:0000255|PROSITE- ProRule PRU00887}. # SIMILARITY Contains 1 glycine radical domain. {ECO:0000255|PROSITE-ProRule PRU00493}. # SUBCELLULAR LOCATION PFLF_ECOLI Cytoplasm {ECO 0000250}. # TIGRFAMs TIGR01774 PFL2-3 # UniPathway UPA00920 UER00891 # eggNOG COG1882 LUCA # eggNOG ENOG4105C6N Bacteria BLAST swissprot:PFLF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PFLF_ECOLI BioCyc ECOL316407:JW0807-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0807-MONOMER BioCyc EcoCyc:G6426-MONOMER http://biocyc.org/getid?id=EcoCyc:G6426-MONOMER COG COG1882 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1882 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.54 http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.54 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.3.1.54 http://enzyme.expasy.org/EC/2.3.1.54 EchoBASE EB3112 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3112 EcoGene EG13328 http://www.ecogene.org/geneInfo.php?eg_id=EG13328 EnsemblBacteria AAC73910 http://www.ensemblgenomes.org/id/AAC73910 EnsemblBacteria AAC73910 http://www.ensemblgenomes.org/id/AAC73910 EnsemblBacteria BAA35504 http://www.ensemblgenomes.org/id/BAA35504 EnsemblBacteria BAA35504 http://www.ensemblgenomes.org/id/BAA35504 EnsemblBacteria BAA35504 http://www.ensemblgenomes.org/id/BAA35504 EnsemblBacteria b0823 http://www.ensemblgenomes.org/id/b0823 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008861 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008861 GO_function GO:0016407 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016407 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GeneID 945444 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945444 HOGENOM HOG000274400 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000274400&db=HOGENOM6 InParanoid P75793 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75793 IntAct P75793 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75793* IntEnz 2.3.1.54 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.54 InterPro IPR001150 http://www.ebi.ac.uk/interpro/entry/IPR001150 InterPro IPR004184 http://www.ebi.ac.uk/interpro/entry/IPR004184 InterPro IPR005949 http://www.ebi.ac.uk/interpro/entry/IPR005949 InterPro IPR010098 http://www.ebi.ac.uk/interpro/entry/IPR010098 InterPro IPR019777 http://www.ebi.ac.uk/interpro/entry/IPR019777 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0807 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0807 KEGG_Gene eco:b0823 http://www.genome.jp/dbget-bin/www_bget?eco:b0823 KEGG_Orthology KO:K00656 http://www.genome.jp/dbget-bin/www_bget?KO:K00656 KEGG_Pathway ko00620 http://www.genome.jp/kegg-bin/show_pathway?ko00620 KEGG_Pathway ko00640 http://www.genome.jp/kegg-bin/show_pathway?ko00640 KEGG_Pathway ko00650 http://www.genome.jp/kegg-bin/show_pathway?ko00650 KEGG_Reaction rn:R00212 http://www.genome.jp/dbget-bin/www_bget?rn:R00212 KEGG_Reaction rn:R06987 http://www.genome.jp/dbget-bin/www_bget?rn:R06987 OMA ENCDIIA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ENCDIIA PROSITE PS00850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00850 PROSITE PS51149 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51149 PROSITE PS51554 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51554 PSORT swissprot:PFLF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PFLF_ECOLI PSORT-B swissprot:PFLF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PFLF_ECOLI PSORT2 swissprot:PFLF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PFLF_ECOLI Pfam PF01228 http://pfam.xfam.org/family/PF01228 Pfam PF02901 http://pfam.xfam.org/family/PF02901 Phobius swissprot:PFLF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PFLF_ECOLI PhylomeDB P75793 http://phylomedb.org/?seqid=P75793 ProteinModelPortal P75793 http://www.proteinmodelportal.org/query/uniprot/P75793 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415344 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415344 RefSeq WP_000209309 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000209309 SMR P75793 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75793 STRING 511145.b0823 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0823&targetmode=cogs STRING COG1882 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1882&targetmode=cogs TIGRFAMs TIGR01774 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01774 UniProtKB PFLF_ECOLI http://www.uniprot.org/uniprot/PFLF_ECOLI UniProtKB-AC P75793 http://www.uniprot.org/uniprot/P75793 charge swissprot:PFLF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PFLF_ECOLI eggNOG COG1882 http://eggnogapi.embl.de/nog_data/html/tree/COG1882 eggNOG ENOG4105C6N http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C6N epestfind swissprot:PFLF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PFLF_ECOLI garnier swissprot:PFLF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PFLF_ECOLI helixturnhelix swissprot:PFLF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PFLF_ECOLI hmoment swissprot:PFLF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PFLF_ECOLI iep swissprot:PFLF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PFLF_ECOLI inforesidue swissprot:PFLF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PFLF_ECOLI octanol swissprot:PFLF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PFLF_ECOLI pepcoil swissprot:PFLF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PFLF_ECOLI pepdigest swissprot:PFLF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PFLF_ECOLI pepinfo swissprot:PFLF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PFLF_ECOLI pepnet swissprot:PFLF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PFLF_ECOLI pepstats swissprot:PFLF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PFLF_ECOLI pepwheel swissprot:PFLF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PFLF_ECOLI pepwindow swissprot:PFLF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PFLF_ECOLI sigcleave swissprot:PFLF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PFLF_ECOLI ## Database ID URL or Descriptions # BioGrid 4262260 2 # DOMAIN NORR_ECOLI Deletion of amino acids 30-164 allows induction of NO reductase activity even in the absence of NO, i.e. the need for an NO-induced signal has been bypassed. # EcoGene EG12108 norR # FUNCTION NORR_ECOLI Required for the expression of anaerobic nitric oxide (NO) reductase, acts as a transcriptional activator for at least the norVW operon. Activation also requires sigma-54. Not required for induction of the aerobic NO-detoxifying enzyme NO dioxygenase. Binds to the promoter region of norVW, to a consensus target sequence, GT-(N7)-AC, which is highly conserved among proteobacteria. {ECO 0000269|PubMed 11751865, ECO 0000269|PubMed 12586421}. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_process GO:0000160 phosphorelay signal transduction system; IEA:UniProtKB-HAMAP. # GO_process GO:0006351 transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_component GO:0005622 intracellular # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.60 -; 1. # Gene3D 3.30.450.40 -; 1. # Gene3D 3.40.50.300 -; 1. # HAMAP MF_01314 NorR # INDUCTION NORR_ECOLI By anaerobic conditions, however not induced by NO alone. # InterPro IPR002078 Sigma_54_int # InterPro IPR003018 GAF # InterPro IPR003593 AAA+_ATPase # InterPro IPR009057 Homeodomain-like # InterPro IPR023944 NorR # InterPro IPR025662 Sigma_54_int_dom_ATP-bd_1 # InterPro IPR025943 Sigma_54_int_dom_ATP-bd_2 # InterPro IPR025944 Sigma_54_int_dom_CS # InterPro IPR027417 P-loop_NTPase # InterPro IPR029016 GAF_dom-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko03000 Transcription factors # KEGG_Pathway ko05132 Salmonella infection # Organism NORR_ECOLI Escherichia coli (strain K12) # PATHWAY NORR_ECOLI Nitrogen metabolism; nitric oxide reduction. # PATRIC 32120816 VBIEscCol129921_2800 # PIR A65051 A65051 # PROSITE PS00675 SIGMA54_INTERACT_1 # PROSITE PS00676 SIGMA54_INTERACT_2 # PROSITE PS00688 SIGMA54_INTERACT_3 # PROSITE PS50045 SIGMA54_INTERACT_4 # Pfam PF00158 Sigma54_activat # Pfam PF01590 GAF # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NORR_ECOLI Anaerobic nitric oxide reductase transcription regulator NorR # RefSeq NP_417189 NC_000913.3 # RefSeq WP_000010749 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA69218.1; Type=Frameshift; Positions=324; Evidence={ECO:0000305}; Sequence=AAA69219.1; Type=Frameshift; Positions=324; Evidence={ECO 0000305}; Sequence=AAA92665.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; # SIMILARITY Contains 1 sigma-54 factor interaction domain. {ECO 0000305}. # SMART SM00065 GAF # SMART SM00382 AAA # SUPFAM SSF46689 SSF46689 # SUPFAM SSF52540 SSF52540 # SUPFAM SSF55781 SSF55781 # eggNOG COG3604 LUCA # eggNOG ENOG4108JUA Bacteria BLAST swissprot:NORR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NORR_ECOLI BioCyc ECOL316407:JW5843-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5843-MONOMER BioCyc EcoCyc:EG12108-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12108-MONOMER COG COG3604 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3604 DIP DIP-12092N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12092N DOI 10.1016/S0378-1097(02)01186-2 http://dx.doi.org/10.1016/S0378-1097(02)01186-2 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M110471200 http://dx.doi.org/10.1074/jbc.M110471200 DOI 10.1074/jbc.M212462200 http://dx.doi.org/10.1074/jbc.M212462200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.186.19.6656-6660.2004 http://dx.doi.org/10.1128/JB.186.19.6656-6660.2004 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D28595 http://www.ebi.ac.uk/ena/data/view/D28595 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U03846 http://www.ebi.ac.uk/ena/data/view/U03846 EMBL U03846 http://www.ebi.ac.uk/ena/data/view/U03846 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EchoBASE EB2032 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2032 EcoGene EG12108 http://www.ecogene.org/geneInfo.php?eg_id=EG12108 EnsemblBacteria AAC75751 http://www.ensemblgenomes.org/id/AAC75751 EnsemblBacteria AAC75751 http://www.ensemblgenomes.org/id/AAC75751 EnsemblBacteria BAE76786 http://www.ensemblgenomes.org/id/BAE76786 EnsemblBacteria BAE76786 http://www.ensemblgenomes.org/id/BAE76786 EnsemblBacteria BAE76786 http://www.ensemblgenomes.org/id/BAE76786 EnsemblBacteria b2709 http://www.ensemblgenomes.org/id/b2709 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 Gene3D 3.30.450.40 http://www.cathdb.info/version/latest/superfamily/3.30.450.40 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947186 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947186 HAMAP MF_01314 http://hamap.expasy.org/unirule/MF_01314 HOGENOM HOG000058487 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000058487&db=HOGENOM6 InParanoid P37013 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37013 InterPro IPR002078 http://www.ebi.ac.uk/interpro/entry/IPR002078 InterPro IPR003018 http://www.ebi.ac.uk/interpro/entry/IPR003018 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR023944 http://www.ebi.ac.uk/interpro/entry/IPR023944 InterPro IPR025662 http://www.ebi.ac.uk/interpro/entry/IPR025662 InterPro IPR025943 http://www.ebi.ac.uk/interpro/entry/IPR025943 InterPro IPR025944 http://www.ebi.ac.uk/interpro/entry/IPR025944 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR029016 http://www.ebi.ac.uk/interpro/entry/IPR029016 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW5843 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5843 KEGG_Gene eco:b2709 http://www.genome.jp/dbget-bin/www_bget?eco:b2709 KEGG_Orthology KO:K12266 http://www.genome.jp/dbget-bin/www_bget?KO:K12266 KEGG_Pathway ko05132 http://www.genome.jp/kegg-bin/show_pathway?ko05132 OMA LRYEAHQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LRYEAHQ PROSITE PS00675 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00675 PROSITE PS00676 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00676 PROSITE PS00688 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00688 PROSITE PS50045 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50045 PSORT swissprot:NORR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NORR_ECOLI PSORT-B swissprot:NORR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NORR_ECOLI PSORT2 swissprot:NORR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NORR_ECOLI Pfam PF00158 http://pfam.xfam.org/family/PF00158 Pfam PF01590 http://pfam.xfam.org/family/PF01590 Phobius swissprot:NORR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NORR_ECOLI PhylomeDB P37013 http://phylomedb.org/?seqid=P37013 ProteinModelPortal P37013 http://www.proteinmodelportal.org/query/uniprot/P37013 PubMed 11751865 http://www.ncbi.nlm.nih.gov/pubmed/11751865 PubMed 12529359 http://www.ncbi.nlm.nih.gov/pubmed/12529359 PubMed 12586421 http://www.ncbi.nlm.nih.gov/pubmed/12586421 PubMed 15375149 http://www.ncbi.nlm.nih.gov/pubmed/15375149 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7894055 http://www.ncbi.nlm.nih.gov/pubmed/7894055 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417189 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417189 RefSeq WP_000010749 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000010749 SMART SM00065 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00065 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P37013 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37013 STRING 511145.b2709 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2709&targetmode=cogs STRING COG3604 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3604&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SUPFAM SSF55781 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55781 UniProtKB NORR_ECOLI http://www.uniprot.org/uniprot/NORR_ECOLI UniProtKB-AC P37013 http://www.uniprot.org/uniprot/P37013 charge swissprot:NORR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NORR_ECOLI eggNOG COG3604 http://eggnogapi.embl.de/nog_data/html/tree/COG3604 eggNOG ENOG4108JUA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108JUA epestfind swissprot:NORR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NORR_ECOLI garnier swissprot:NORR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NORR_ECOLI helixturnhelix swissprot:NORR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NORR_ECOLI hmoment swissprot:NORR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NORR_ECOLI iep swissprot:NORR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NORR_ECOLI inforesidue swissprot:NORR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NORR_ECOLI octanol swissprot:NORR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NORR_ECOLI pepcoil swissprot:NORR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NORR_ECOLI pepdigest swissprot:NORR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NORR_ECOLI pepinfo swissprot:NORR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NORR_ECOLI pepnet swissprot:NORR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NORR_ECOLI pepstats swissprot:NORR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NORR_ECOLI pepwheel swissprot:NORR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NORR_ECOLI pepwindow swissprot:NORR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NORR_ECOLI sigcleave swissprot:NORR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NORR_ECOLI ## Database ID URL or Descriptions # AltName AG43_ECOLI Fluffing protein # AltName AG43_ECOLI Fluffing protein # DOMAIN AG43_ECOLI The signal peptide, cleaved at the inner membrane, guides the autotransporter protein to the periplasmic space. Then, insertion of the C-terminal translocator domain in the outer membrane forms a hydrophilic pore for the translocation of the passenger domain to the bacterial cell surface, with subsequent cleavage. Finally, the mature protein remains tightly associated with the bacterium (Probable). {ECO 0000305}. # EcoGene EG12686 flu # FUNCTION AG43_ECOLI Controls colony form variation and autoaggregation. May function as an adhesin. {ECO 0000269|PubMed 22466966}. # GO_component GO:0005576 extracellular region; IEA:UniProtKB-SubCell. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_component GO:0009986 cell surface; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005576 extracellular region # Gene3D 2.160.20.20 -; 1. # Gene3D 2.40.128.130 -; 1. # IntAct P39180 4 # InterPro IPR005546 Autotransporte_beta # InterPro IPR011050 Pectin_lyase_fold/virulence # InterPro IPR012332 P22_tailspike_C-like # InterPro IPR024973 ESPR # InterPro IPR030930 AIDA # KEGG_Brite ko02044 Secretion system # Organism AG43_ECOLI Escherichia coli (strain K12) # PATRIC 32119333 VBIEscCol129921_2076 # PROSITE PS51208 AUTOTRANSPORTER # Pfam PF03797 Autotransporter # Pfam PF13018 ESPR # Pfam PF16168 AIDA; 3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AG43_ECOLI Antigen 43 # RecName AG43_ECOLI Antigen 43 alpha chain # RecName AG43_ECOLI Antigen 43 alpha chain # RecName AG43_ECOLI Antigen 43 beta chain # RefSeq WP_000820410 NZ_LN832404.1 # RefSeq YP_026164 NC_000913.3 # SIMILARITY Contains 1 autotransporter (TC 1.B.12) domain. {ECO:0000255|PROSITE-ProRule PRU00556}. # SMART SM00869 Autotransporter # SUBCELLULAR LOCATION AG43_ECOLI Antigen 43 Periplasm {ECO 0000250}. # SUBCELLULAR LOCATION AG43_ECOLI Antigen 43 alpha chain Secreted. Cell surface. Note=The cell surface component is about 60 kDa and can be released by mild heat treatment. # SUBCELLULAR LOCATION AG43_ECOLI Antigen 43 beta chain Cell outer membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # SUPFAM SSF103515 SSF103515 # SUPFAM SSF51126 SSF51126; 2 # TCDB 1.B.12.8 the autotransporter-1 (at-1) family # TIGRFAMs TIGR04415 O_hepto_targRPT; 5 # eggNOG COG3468 LUCA # eggNOG ENOG4105F4K Bacteria BLAST swissprot:AG43_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AG43_ECOLI BioCyc ECOL316407:JW1982-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1982-MONOMER BioCyc EcoCyc:G7080-MONOMER http://biocyc.org/getid?id=EcoCyc:G7080-MONOMER COG COG3468 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3468 DIP DIP-2892N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-2892N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsmb.2261 http://dx.doi.org/10.1038/nsmb.2261 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1111/j.1574-6968.1997.tb10317.x http://dx.doi.org/10.1111/j.1574-6968.1997.tb10317.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U24429 http://www.ebi.ac.uk/ena/data/view/U24429 EchoBASE EB2550 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2550 EcoGene EG12686 http://www.ecogene.org/geneInfo.php?eg_id=EG12686 EnsemblBacteria AAT48141 http://www.ensemblgenomes.org/id/AAT48141 EnsemblBacteria AAT48141 http://www.ensemblgenomes.org/id/AAT48141 EnsemblBacteria BAA15825 http://www.ensemblgenomes.org/id/BAA15825 EnsemblBacteria BAA15825 http://www.ensemblgenomes.org/id/BAA15825 EnsemblBacteria BAA15825 http://www.ensemblgenomes.org/id/BAA15825 EnsemblBacteria b2000 http://www.ensemblgenomes.org/id/b2000 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005576 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576 GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0009986 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005576 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576 Gene3D 2.160.20.20 http://www.cathdb.info/version/latest/superfamily/2.160.20.20 Gene3D 2.40.128.130 http://www.cathdb.info/version/latest/superfamily/2.40.128.130 GeneID 946540 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946540 HOGENOM HOG000009569 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009569&db=HOGENOM6 IntAct P39180 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39180* InterPro IPR005546 http://www.ebi.ac.uk/interpro/entry/IPR005546 InterPro IPR011050 http://www.ebi.ac.uk/interpro/entry/IPR011050 InterPro IPR012332 http://www.ebi.ac.uk/interpro/entry/IPR012332 InterPro IPR024973 http://www.ebi.ac.uk/interpro/entry/IPR024973 InterPro IPR030930 http://www.ebi.ac.uk/interpro/entry/IPR030930 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW1982 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1982 KEGG_Gene eco:b2000 http://www.genome.jp/dbget-bin/www_bget?eco:b2000 KEGG_Orthology KO:K12687 http://www.genome.jp/dbget-bin/www_bget?KO:K12687 OMA IWQHLSL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IWQHLSL PROSITE PS51208 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51208 PSORT swissprot:AG43_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AG43_ECOLI PSORT-B swissprot:AG43_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AG43_ECOLI PSORT2 swissprot:AG43_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AG43_ECOLI Pfam PF03797 http://pfam.xfam.org/family/PF03797 Pfam PF13018 http://pfam.xfam.org/family/PF13018 Pfam PF16168 http://pfam.xfam.org/family/PF16168 Phobius swissprot:AG43_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AG43_ECOLI PhylomeDB P39180 http://phylomedb.org/?seqid=P39180 ProteinModelPortal P39180 http://www.proteinmodelportal.org/query/uniprot/P39180 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22466966 http://www.ncbi.nlm.nih.gov/pubmed/22466966 PubMed 2661530 http://www.ncbi.nlm.nih.gov/pubmed/2661530 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9103983 http://www.ncbi.nlm.nih.gov/pubmed/9103983 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq WP_000820410 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000820410 RefSeq YP_026164 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026164 SMART SM00869 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00869 SMR P39180 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39180 STRING 511145.b2000 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2000&targetmode=cogs STRING COG3468 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3468&targetmode=cogs SUPFAM SSF103515 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103515 SUPFAM SSF51126 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51126 TCDB 1.B.12.8 http://www.tcdb.org/search/result.php?tc=1.B.12.8 TIGRFAMs TIGR04415 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR04415 UniProtKB AG43_ECOLI http://www.uniprot.org/uniprot/AG43_ECOLI UniProtKB-AC P39180 http://www.uniprot.org/uniprot/P39180 charge swissprot:AG43_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AG43_ECOLI eggNOG COG3468 http://eggnogapi.embl.de/nog_data/html/tree/COG3468 eggNOG ENOG4105F4K http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F4K epestfind swissprot:AG43_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AG43_ECOLI garnier swissprot:AG43_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AG43_ECOLI helixturnhelix swissprot:AG43_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AG43_ECOLI hmoment swissprot:AG43_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AG43_ECOLI iep swissprot:AG43_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AG43_ECOLI inforesidue swissprot:AG43_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AG43_ECOLI octanol swissprot:AG43_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AG43_ECOLI pepcoil swissprot:AG43_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AG43_ECOLI pepdigest swissprot:AG43_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AG43_ECOLI pepinfo swissprot:AG43_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AG43_ECOLI pepnet swissprot:AG43_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AG43_ECOLI pepstats swissprot:AG43_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AG43_ECOLI pepwheel swissprot:AG43_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AG43_ECOLI pepwindow swissprot:AG43_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AG43_ECOLI sigcleave swissprot:AG43_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AG43_ECOLI ## Database ID URL or Descriptions # AltName PLDB_ECOLI Lecithinase B # BioGrid 4262616 216 # CATALYTIC ACTIVITY PLDB_ECOLI 2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate. # ESTHER ecoli-pldb Monoglyceridelipase_lysophospholip # EcoGene EG10739 pldB # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016020 membrane; IDA:EcoliWiki. # GO_function GO:0004622 lysophospholipase activity; IDA:EcoCyc. # GO_function GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups; IDA:EcoCyc. # GO_process GO:0006629 lipid metabolic process; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0006629 lipid metabolic process # Gene3D 3.40.50.1820 -; 1. # INTERACTION PLDB_ECOLI Q46864 mqsA; NbExp=2; IntAct=EBI-9134416, EBI-1120353; # IntAct P07000 11 # InterPro IPR022742 Hydrolase_4 # InterPro IPR029058 AB_hydrolase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00564 Glycerophospholipid metabolism # MISCELLANEOUS PLDB_ECOLI In addition this protein catalyzes a transacylation reaction to produce acyl phosphatidylglycerol by transfer of the acidyl residue of 2-acyl lysophospholipid to phosphatidylglycerol. # MISCELLANEOUS PLDB_ECOLI Lysophospholipases from various sources vary widely in molecular weight, substrate specificity, and subcellular localization. # Organism PLDB_ECOLI Escherichia coli (strain K12) # PATRIC 32123151 VBIEscCol129921_3941 # PIR B65187 PSECL2 # Pfam PF12146 Hydrolase_4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PLDB_ECOLI Lysophospholipase L2 # RefSeq WP_000487654 NZ_LN832404.1 # RefSeq YP_026266 NC_000913.3 # SUBCELLULAR LOCATION PLDB_ECOLI Cell inner membrane; Peripheral membrane protein. # SUPFAM SSF53474 SSF53474 # eggNOG COG2267 LUCA # eggNOG ENOG4108EUD Bacteria BLAST swissprot:PLDB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PLDB_ECOLI BioCyc ECOL316407:JW5584-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5584-MONOMER BioCyc EcoCyc:EG10739-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10739-MONOMER BioCyc MetaCyc:EG10739-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10739-MONOMER COG COG2267 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2267 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.1.5 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.1.5 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X03155 http://www.ebi.ac.uk/ena/data/view/X03155 ENZYME 3.1.1.5 http://enzyme.expasy.org/EC/3.1.1.5 EchoBASE EB0732 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0732 EcoGene EG10739 http://www.ecogene.org/geneInfo.php?eg_id=EG10739 EnsemblBacteria AAT48224 http://www.ensemblgenomes.org/id/AAT48224 EnsemblBacteria AAT48224 http://www.ensemblgenomes.org/id/AAT48224 EnsemblBacteria BAE77476 http://www.ensemblgenomes.org/id/BAE77476 EnsemblBacteria BAE77476 http://www.ensemblgenomes.org/id/BAE77476 EnsemblBacteria BAE77476 http://www.ensemblgenomes.org/id/BAE77476 EnsemblBacteria b3825 http://www.ensemblgenomes.org/id/b3825 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0004622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004622 GO_function GO:0016747 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016747 GO_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 Gene3D 3.40.50.1820 http://www.cathdb.info/version/latest/superfamily/3.40.50.1820 GeneID 948314 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948314 HOGENOM HOG000285163 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000285163&db=HOGENOM6 InParanoid P07000 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P07000 IntAct P07000 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P07000* IntEnz 3.1.1.5 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.1.5 InterPro IPR022742 http://www.ebi.ac.uk/interpro/entry/IPR022742 InterPro IPR029058 http://www.ebi.ac.uk/interpro/entry/IPR029058 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5584 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5584 KEGG_Gene eco:b3825 http://www.genome.jp/dbget-bin/www_bget?eco:b3825 KEGG_Orthology KO:K01048 http://www.genome.jp/dbget-bin/www_bget?KO:K01048 KEGG_Pathway ko00564 http://www.genome.jp/kegg-bin/show_pathway?ko00564 OMA VVLPDCP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VVLPDCP PSORT swissprot:PLDB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PLDB_ECOLI PSORT-B swissprot:PLDB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PLDB_ECOLI PSORT2 swissprot:PLDB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PLDB_ECOLI Pfam PF12146 http://pfam.xfam.org/family/PF12146 Phobius swissprot:PLDB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PLDB_ECOLI PhylomeDB P07000 http://phylomedb.org/?seqid=P07000 ProteinModelPortal P07000 http://www.proteinmodelportal.org/query/uniprot/P07000 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3908445 http://www.ncbi.nlm.nih.gov/pubmed/3908445 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000487654 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000487654 RefSeq YP_026266 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026266 SMR P07000 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P07000 STRING 511145.b3825 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3825&targetmode=cogs STRING COG2267 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2267&targetmode=cogs SUPFAM SSF53474 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53474 UniProtKB PLDB_ECOLI http://www.uniprot.org/uniprot/PLDB_ECOLI UniProtKB-AC P07000 http://www.uniprot.org/uniprot/P07000 charge swissprot:PLDB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PLDB_ECOLI eggNOG COG2267 http://eggnogapi.embl.de/nog_data/html/tree/COG2267 eggNOG ENOG4108EUD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108EUD epestfind swissprot:PLDB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PLDB_ECOLI garnier swissprot:PLDB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PLDB_ECOLI helixturnhelix swissprot:PLDB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PLDB_ECOLI hmoment swissprot:PLDB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PLDB_ECOLI iep swissprot:PLDB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PLDB_ECOLI inforesidue swissprot:PLDB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PLDB_ECOLI octanol swissprot:PLDB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PLDB_ECOLI pepcoil swissprot:PLDB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PLDB_ECOLI pepdigest swissprot:PLDB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PLDB_ECOLI pepinfo swissprot:PLDB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PLDB_ECOLI pepnet swissprot:PLDB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PLDB_ECOLI pepstats swissprot:PLDB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PLDB_ECOLI pepwheel swissprot:PLDB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PLDB_ECOLI pepwindow swissprot:PLDB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PLDB_ECOLI sigcleave swissprot:PLDB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PLDB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260744 32 # EcoGene EG13128 ygcU # GO_function GO:0008609 alkylglycerone-phosphate synthase activity; IEA:InterPro. # GO_function GO:0016614 oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro. # GO_function GO:0050660 flavin adenine dinucleotide binding; IEA:InterPro. # GO_process GO:0008610 lipid biosynthetic process; IEA:InterPro. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 1.10.45.10 -; 1. # Gene3D 3.30.43.10 -; 1. # Gene3D 3.30.465.10 -; 1. # InterPro IPR004113 FAD-linked_oxidase_C # InterPro IPR006094 Oxid_FAD_bind_N # InterPro IPR016164 FAD-linked_Oxase-like_C # InterPro IPR016166 FAD-bd_2 # InterPro IPR016167 FAD-bd_2_sub1 # InterPro IPR016169 CO_DH_flavot_FAD-bd_sub2 # InterPro IPR016171 Vanillyl_alc_oxidase_C-sub2 # InterPro IPR025650 Alkyl-DHAP_Synthase # Organism YGCU_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11748:SF3 PTHR11748:SF3 # PATRIC 32120956 VBIEscCol129921_2870 # PROSITE PS51387 FAD_PCMH # Pfam PF01565 FAD_binding_4 # Pfam PF02913 FAD-oxidase_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGCU_ECOLI Uncharacterized FAD-linked oxidoreductase YgcU # RefSeq WP_000059307 NZ_LN832404.1 # RefSeq YP_026183 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA69282.1; Type=Frameshift; Positions=90, 208; Evidence={ECO:0000305}; Sequence=AAA69283.1; Type=Frameshift; Positions=90, 208; Evidence={ECO 0000305}; Sequence=AAA69284.1; Type=Frameshift; Positions=90, 208; Evidence={ECO:0000305}; # SIMILARITY Belongs to the FAD-binding oxidoreductase/transferase type 4 family. {ECO 0000305}. # SIMILARITY Contains 1 FAD-binding PCMH-type domain. {ECO:0000255|PROSITE-ProRule PRU00718}. # SUPFAM SSF55103 SSF55103 # SUPFAM SSF56176 SSF56176 # eggNOG COG0277 LUCA # eggNOG ENOG4107R3A Bacteria BLAST swissprot:YGCU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGCU_ECOLI BioCyc ECOL316407:JW5442-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5442-MONOMER BioCyc EcoCyc:G7439-MONOMER http://biocyc.org/getid?id=EcoCyc:G7439-MONOMER DIP DIP-12136N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12136N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- EchoBASE EB2929 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2929 EcoGene EG13128 http://www.ecogene.org/geneInfo.php?eg_id=EG13128 EnsemblBacteria AAT48151 http://www.ensemblgenomes.org/id/AAT48151 EnsemblBacteria AAT48151 http://www.ensemblgenomes.org/id/AAT48151 EnsemblBacteria BAE76849 http://www.ensemblgenomes.org/id/BAE76849 EnsemblBacteria BAE76849 http://www.ensemblgenomes.org/id/BAE76849 EnsemblBacteria BAE76849 http://www.ensemblgenomes.org/id/BAE76849 EnsemblBacteria b4463 http://www.ensemblgenomes.org/id/b4463 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008609 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008609 GO_function GO:0016614 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016614 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_process GO:0008610 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008610 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016765 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 1.10.45.10 http://www.cathdb.info/version/latest/superfamily/1.10.45.10 Gene3D 3.30.43.10 http://www.cathdb.info/version/latest/superfamily/3.30.43.10 Gene3D 3.30.465.10 http://www.cathdb.info/version/latest/superfamily/3.30.465.10 GeneID 2847709 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2847709 HOGENOM HOG000230996 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230996&db=HOGENOM6 InParanoid Q46911 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46911 IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR004113 http://www.ebi.ac.uk/interpro/entry/IPR004113 InterPro IPR006094 http://www.ebi.ac.uk/interpro/entry/IPR006094 InterPro IPR016164 http://www.ebi.ac.uk/interpro/entry/IPR016164 InterPro IPR016166 http://www.ebi.ac.uk/interpro/entry/IPR016166 InterPro IPR016167 http://www.ebi.ac.uk/interpro/entry/IPR016167 InterPro IPR016169 http://www.ebi.ac.uk/interpro/entry/IPR016169 InterPro IPR016171 http://www.ebi.ac.uk/interpro/entry/IPR016171 InterPro IPR025650 http://www.ebi.ac.uk/interpro/entry/IPR025650 KEGG_Gene ecj:JW5442 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5442 KEGG_Gene eco:b4463 http://www.genome.jp/dbget-bin/www_bget?eco:b4463 OMA EIMKWNG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EIMKWNG PANTHER PTHR11748:SF3 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11748:SF3 PROSITE PS51387 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51387 PSORT swissprot:YGCU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGCU_ECOLI PSORT-B swissprot:YGCU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGCU_ECOLI PSORT2 swissprot:YGCU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGCU_ECOLI Pfam PF01565 http://pfam.xfam.org/family/PF01565 Pfam PF02913 http://pfam.xfam.org/family/PF02913 Phobius swissprot:YGCU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGCU_ECOLI PhylomeDB Q46911 http://phylomedb.org/?seqid=Q46911 ProteinModelPortal Q46911 http://www.proteinmodelportal.org/query/uniprot/Q46911 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000059307 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000059307 RefSeq YP_026183 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026183 SMR Q46911 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46911 STRING 511145.b4463 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4463&targetmode=cogs SUPFAM SSF55103 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55103 SUPFAM SSF56176 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56176 UniProtKB YGCU_ECOLI http://www.uniprot.org/uniprot/YGCU_ECOLI UniProtKB-AC Q46911 http://www.uniprot.org/uniprot/Q46911 charge swissprot:YGCU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGCU_ECOLI eggNOG COG0277 http://eggnogapi.embl.de/nog_data/html/tree/COG0277 eggNOG ENOG4107R3A http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107R3A epestfind swissprot:YGCU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGCU_ECOLI garnier swissprot:YGCU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGCU_ECOLI helixturnhelix swissprot:YGCU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGCU_ECOLI hmoment swissprot:YGCU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGCU_ECOLI iep swissprot:YGCU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGCU_ECOLI inforesidue swissprot:YGCU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGCU_ECOLI octanol swissprot:YGCU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGCU_ECOLI pepcoil swissprot:YGCU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGCU_ECOLI pepdigest swissprot:YGCU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGCU_ECOLI pepinfo swissprot:YGCU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGCU_ECOLI pepnet swissprot:YGCU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGCU_ECOLI pepstats swissprot:YGCU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGCU_ECOLI pepwheel swissprot:YGCU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGCU_ECOLI pepwindow swissprot:YGCU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGCU_ECOLI sigcleave swissprot:YGCU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGCU_ECOLI ## Database ID URL or Descriptions # AltName RPOB_ECOLI RNA polymerase subunit beta # AltName RPOB_ECOLI Transcriptase subunit beta # BioGrid 4263472 4 # CATALYTIC ACTIVITY RPOB_ECOLI Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). # CDD cd00653 RNA_pol_B_RPB2 # DrugBank DB00615 Rifabutin # DrugBank DB01045 Rifampicin # DrugBank DB01220 Rifaximin # EcoGene EG10894 rpoB # FUNCTION RPOB_ECOLI DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. {ECO 0000269|PubMed 1646077}. # GO_component GO:0000428 DNA-directed RNA polymerase complex; IBA:GO_Central. # GO_component GO:0005737 cytoplasm; IDA:UniProtKB. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0003899 DNA-directed RNA polymerase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0032549 ribonucleoside binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 2.30.150.10 -; 1. # Gene3D 2.40.270.10 -; 2. # Gene3D 2.40.50.150 -; 2. # Gene3D 3.90.1110.10 -; 2. # HAMAP MF_01321 RNApol_bact_RpoB # INTERACTION RPOB_ECOLI P60240 rapA; NbExp=3; IntAct=EBI-544996, EBI-551542; P0A8T7 rpoC; NbExp=7; IntAct=EBI-544996, EBI-543604; # IntAct P0A8V2 99 # InterPro IPR007120 DNA-dir_RNA_pol_su2_6 # InterPro IPR007121 RNA_pol_bsu_CS # InterPro IPR007641 RNA_pol_Rpb2_7 # InterPro IPR007642 RNA_pol_Rpb2_2 # InterPro IPR007644 RNA_pol_bsu_protrusion # InterPro IPR007645 RNA_pol_Rpb2_3 # InterPro IPR010243 RNA_pol_bsu_bac # InterPro IPR014724 RNA_pol_RPB2_OB-fold # InterPro IPR015712 DNA-dir_RNA_pol_su2 # InterPro IPR019462 DNA-dir_RNA_pol_bsu_external_1 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03021 M00183 RNA polymerase, bacteria # KEGG_Brite ko03021 Transcription machinery # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Brite ko03400 M00183 RNA polymerase, bacteria # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00240 Pyrimidine metabolism # KEGG_Pathway ko03020 RNA polymerase # Organism RPOB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR20856 PTHR20856; 5 # PATRIC 32123495 VBIEscCol129921_4100 # PDB 3IYD EM; -; C=1-1342 # PDB 3LTI X-ray; 1.60 A; A=152-443 # PDB 3LU0 EM; -; C=1-1342 # PDB 3T72 X-ray; 4.33 A; o/q=896-910 # PDB 3TBI X-ray; 3.00 A; B=831-1057 # PDB 4JK1 X-ray; 3.90 A; C/H=1-1342 # PDB 4JK2 X-ray; 4.20 A; C/H=1-1342 # PDB 4KMU X-ray; 3.85 A; C/H=1-1342 # PDB 4KN4 X-ray; 3.96 A; C/H=1-1342 # PDB 4KN7 X-ray; 3.69 A; C/H=1-1342 # PDB 4MEX X-ray; 3.90 A; C/I=1-1342 # PDB 4MEY X-ray; 3.95 A; C/I=1-1342 # PDB 4S20 X-ray; 4.70 A; C/H=1-1342 # PDB 4XSX X-ray; 3.71 A; C/I=1-1342 # PDB 4XSY X-ray; 4.01 A; C/I=1-1342 # PDB 4XSZ X-ray; 3.68 A; C/I=1-1342 # PDB 4YG2 X-ray; 3.70 A; C/I=1-1342 # PDB 4YLN X-ray; 5.50 A; C/I/O=1-1342 # PDB 4YLO X-ray; 6.00 A; C/I/O=1-1342 # PDB 4YLP X-ray; 5.50 A; C/I/O=1-1342 # PDB 4ZH2 X-ray; 4.20 A; C/I=1-1342 # PDB 4ZH3 X-ray; 4.08 A; C/I=1-1342 # PDB 4ZH4 X-ray; 3.99 A; C/I=1-1342 # PDB 5BYH X-ray; 3.76 A; C=1-1342 # PDB 5EZK X-ray; 8.50 A; C=1-1342 # PDB 5IPL X-ray; 3.60 A; C=1-1342 # PDB 5IPM X-ray; 4.20 A; C=1-1342 # PDB 5IPN X-ray; 4.61 A; C=1-1342 # PIR F65205 RNECB # PROSITE PS01166 RNA_POL_BETA # PTM RPOB_ECOLI Acetylated on several lysine residues in the presence of glucose. {ECO 0000269|PubMed 18723842, ECO 0000269|PubMed 21696463}. # Pfam PF00562 RNA_pol_Rpb2_6 # Pfam PF04560 RNA_pol_Rpb2_7 # Pfam PF04561 RNA_pol_Rpb2_2; 2 # Pfam PF04563 RNA_pol_Rpb2_1 # Pfam PF04565 RNA_pol_Rpb2_3 # Pfam PF10385 RNA_pol_Rpb2_45 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RPOB_ECOLI DNA-directed RNA polymerase subunit beta # RefSeq NP_418414 NC_000913.3 # RefSeq WP_000263098 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=Ref.7; Type=Miscellaneous discrepancy; Evidence={ECO 0000305}; # SIMILARITY Belongs to the RNA polymerase beta chain family. {ECO 0000305}. # SUBUNIT RPOB_ECOLI The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. {ECO 0000269|PubMed 1646077, ECO 0000269|PubMed 19903881}. # TIGRFAMs TIGR02013 rpoB # eggNOG COG0085 LUCA # eggNOG ENOG4107QIH Bacteria BLAST swissprot:RPOB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RPOB_ECOLI BioCyc ECOL316407:JW3950-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3950-MONOMER BioCyc EcoCyc:RPOB-MONOMER http://biocyc.org/getid?id=EcoCyc:RPOB-MONOMER BioCyc MetaCyc:RPOB-MONOMER http://biocyc.org/getid?id=MetaCyc:RPOB-MONOMER COG COG0085 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0085 DIP DIP-35777N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35777N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0014-5793(75)81001-5 http://dx.doi.org/10.1016/0014-5793(75)81001-5 DOI 10.1016/0092-8674(91)90553-B http://dx.doi.org/10.1016/0092-8674(91)90553-B DOI 10.1016/0378-1119(80)90076-1 http://dx.doi.org/10.1016/0378-1119(80)90076-1 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0908782106 http://dx.doi.org/10.1073/pnas.0908782106 DOI 10.1073/pnas.76.4.1697 http://dx.doi.org/10.1073/pnas.76.4.1697 DOI 10.1073/pnas.88.14.6018 http://dx.doi.org/10.1073/pnas.88.14.6018 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1111/j.1365-2958.2011.07742.x http://dx.doi.org/10.1111/j.1365-2958.2011.07742.x DOI 10.1111/j.1432-1033.1981.tb05381.x http://dx.doi.org/10.1111/j.1432-1033.1981.tb05381.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB00615 http://www.drugbank.ca/drugs/DB00615 DrugBank DB01045 http://www.drugbank.ca/drugs/DB01045 DrugBank DB01220 http://www.drugbank.ca/drugs/DB01220 EC_number EC:2.7.7.6 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.6 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M38287 http://www.ebi.ac.uk/ena/data/view/M38287 EMBL M38292 http://www.ebi.ac.uk/ena/data/view/M38292 EMBL M38293 http://www.ebi.ac.uk/ena/data/view/M38293 EMBL M38303 http://www.ebi.ac.uk/ena/data/view/M38303 EMBL M38304 http://www.ebi.ac.uk/ena/data/view/M38304 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U76222 http://www.ebi.ac.uk/ena/data/view/U76222 EMBL U77436 http://www.ebi.ac.uk/ena/data/view/U77436 EMBL V00339 http://www.ebi.ac.uk/ena/data/view/V00339 EMBL V00340 http://www.ebi.ac.uk/ena/data/view/V00340 EMBL V00341 http://www.ebi.ac.uk/ena/data/view/V00341 ENZYME 2.7.7.6 http://enzyme.expasy.org/EC/2.7.7.6 EchoBASE EB0887 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0887 EcoGene EG10894 http://www.ecogene.org/geneInfo.php?eg_id=EG10894 EnsemblBacteria AAC76961 http://www.ensemblgenomes.org/id/AAC76961 EnsemblBacteria AAC76961 http://www.ensemblgenomes.org/id/AAC76961 EnsemblBacteria BAE77333 http://www.ensemblgenomes.org/id/BAE77333 EnsemblBacteria BAE77333 http://www.ensemblgenomes.org/id/BAE77333 EnsemblBacteria BAE77333 http://www.ensemblgenomes.org/id/BAE77333 EnsemblBacteria b3987 http://www.ensemblgenomes.org/id/b3987 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0000428 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000428 GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003899 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003899 GO_function GO:0032549 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032549 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 2.30.150.10 http://www.cathdb.info/version/latest/superfamily/2.30.150.10 Gene3D 2.40.270.10 http://www.cathdb.info/version/latest/superfamily/2.40.270.10 Gene3D 2.40.50.150 http://www.cathdb.info/version/latest/superfamily/2.40.50.150 Gene3D 3.90.1110.10 http://www.cathdb.info/version/latest/superfamily/3.90.1110.10 GeneID 948488 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948488 HAMAP MF_01321 http://hamap.expasy.org/unirule/MF_01321 HOGENOM HOG000218612 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218612&db=HOGENOM6 InParanoid P0A8V2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8V2 IntAct P0A8V2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8V2* IntEnz 2.7.7.6 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.6 InterPro IPR007120 http://www.ebi.ac.uk/interpro/entry/IPR007120 InterPro IPR007121 http://www.ebi.ac.uk/interpro/entry/IPR007121 InterPro IPR007641 http://www.ebi.ac.uk/interpro/entry/IPR007641 InterPro IPR007642 http://www.ebi.ac.uk/interpro/entry/IPR007642 InterPro IPR007644 http://www.ebi.ac.uk/interpro/entry/IPR007644 InterPro IPR007645 http://www.ebi.ac.uk/interpro/entry/IPR007645 InterPro IPR010243 http://www.ebi.ac.uk/interpro/entry/IPR010243 InterPro IPR014724 http://www.ebi.ac.uk/interpro/entry/IPR014724 InterPro IPR015712 http://www.ebi.ac.uk/interpro/entry/IPR015712 InterPro IPR019462 http://www.ebi.ac.uk/interpro/entry/IPR019462 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03021 http://www.genome.jp/dbget-bin/www_bget?ko03021 KEGG_Brite ko03021 http://www.genome.jp/dbget-bin/www_bget?ko03021 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW3950 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3950 KEGG_Gene eco:b3987 http://www.genome.jp/dbget-bin/www_bget?eco:b3987 KEGG_Orthology KO:K03043 http://www.genome.jp/dbget-bin/www_bget?KO:K03043 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Pathway ko03020 http://www.genome.jp/kegg-bin/show_pathway?ko03020 KEGG_Reaction rn:R00435 http://www.genome.jp/dbget-bin/www_bget?rn:R00435 KEGG_Reaction rn:R00441 http://www.genome.jp/dbget-bin/www_bget?rn:R00441 KEGG_Reaction rn:R00442 http://www.genome.jp/dbget-bin/www_bget?rn:R00442 KEGG_Reaction rn:R00443 http://www.genome.jp/dbget-bin/www_bget?rn:R00443 MINT MINT-1222430 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1222430 OMA YFNPKRY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YFNPKRY PANTHER PTHR20856 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20856 PDB 3IYD http://www.ebi.ac.uk/pdbe-srv/view/entry/3IYD PDB 3LTI http://www.ebi.ac.uk/pdbe-srv/view/entry/3LTI PDB 3LU0 http://www.ebi.ac.uk/pdbe-srv/view/entry/3LU0 PDB 3T72 http://www.ebi.ac.uk/pdbe-srv/view/entry/3T72 PDB 3TBI http://www.ebi.ac.uk/pdbe-srv/view/entry/3TBI PDB 4JK1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4JK1 PDB 4JK2 http://www.ebi.ac.uk/pdbe-srv/view/entry/4JK2 PDB 4KMU http://www.ebi.ac.uk/pdbe-srv/view/entry/4KMU PDB 4KN4 http://www.ebi.ac.uk/pdbe-srv/view/entry/4KN4 PDB 4KN7 http://www.ebi.ac.uk/pdbe-srv/view/entry/4KN7 PDB 4MEX http://www.ebi.ac.uk/pdbe-srv/view/entry/4MEX PDB 4MEY http://www.ebi.ac.uk/pdbe-srv/view/entry/4MEY PDB 4S20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4S20 PDB 4XSX http://www.ebi.ac.uk/pdbe-srv/view/entry/4XSX PDB 4XSY http://www.ebi.ac.uk/pdbe-srv/view/entry/4XSY PDB 4XSZ http://www.ebi.ac.uk/pdbe-srv/view/entry/4XSZ PDB 4YG2 http://www.ebi.ac.uk/pdbe-srv/view/entry/4YG2 PDB 4YLN http://www.ebi.ac.uk/pdbe-srv/view/entry/4YLN PDB 4YLO http://www.ebi.ac.uk/pdbe-srv/view/entry/4YLO PDB 4YLP http://www.ebi.ac.uk/pdbe-srv/view/entry/4YLP PDB 4ZH2 http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZH2 PDB 4ZH3 http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZH3 PDB 4ZH4 http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZH4 PDB 5BYH http://www.ebi.ac.uk/pdbe-srv/view/entry/5BYH PDB 5EZK http://www.ebi.ac.uk/pdbe-srv/view/entry/5EZK PDB 5IPL http://www.ebi.ac.uk/pdbe-srv/view/entry/5IPL PDB 5IPM http://www.ebi.ac.uk/pdbe-srv/view/entry/5IPM PDB 5IPN http://www.ebi.ac.uk/pdbe-srv/view/entry/5IPN PDBsum 3IYD http://www.ebi.ac.uk/pdbsum/3IYD PDBsum 3LTI http://www.ebi.ac.uk/pdbsum/3LTI PDBsum 3LU0 http://www.ebi.ac.uk/pdbsum/3LU0 PDBsum 3T72 http://www.ebi.ac.uk/pdbsum/3T72 PDBsum 3TBI http://www.ebi.ac.uk/pdbsum/3TBI PDBsum 4JK1 http://www.ebi.ac.uk/pdbsum/4JK1 PDBsum 4JK2 http://www.ebi.ac.uk/pdbsum/4JK2 PDBsum 4KMU http://www.ebi.ac.uk/pdbsum/4KMU PDBsum 4KN4 http://www.ebi.ac.uk/pdbsum/4KN4 PDBsum 4KN7 http://www.ebi.ac.uk/pdbsum/4KN7 PDBsum 4MEX http://www.ebi.ac.uk/pdbsum/4MEX PDBsum 4MEY http://www.ebi.ac.uk/pdbsum/4MEY PDBsum 4S20 http://www.ebi.ac.uk/pdbsum/4S20 PDBsum 4XSX http://www.ebi.ac.uk/pdbsum/4XSX PDBsum 4XSY http://www.ebi.ac.uk/pdbsum/4XSY PDBsum 4XSZ http://www.ebi.ac.uk/pdbsum/4XSZ PDBsum 4YG2 http://www.ebi.ac.uk/pdbsum/4YG2 PDBsum 4YLN http://www.ebi.ac.uk/pdbsum/4YLN PDBsum 4YLO http://www.ebi.ac.uk/pdbsum/4YLO PDBsum 4YLP http://www.ebi.ac.uk/pdbsum/4YLP PDBsum 4ZH2 http://www.ebi.ac.uk/pdbsum/4ZH2 PDBsum 4ZH3 http://www.ebi.ac.uk/pdbsum/4ZH3 PDBsum 4ZH4 http://www.ebi.ac.uk/pdbsum/4ZH4 PDBsum 5BYH http://www.ebi.ac.uk/pdbsum/5BYH PDBsum 5EZK http://www.ebi.ac.uk/pdbsum/5EZK PDBsum 5IPL http://www.ebi.ac.uk/pdbsum/5IPL PDBsum 5IPM http://www.ebi.ac.uk/pdbsum/5IPM PDBsum 5IPN http://www.ebi.ac.uk/pdbsum/5IPN PROSITE PS01166 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01166 PSORT swissprot:RPOB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RPOB_ECOLI PSORT-B swissprot:RPOB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RPOB_ECOLI PSORT2 swissprot:RPOB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RPOB_ECOLI Pfam PF00562 http://pfam.xfam.org/family/PF00562 Pfam PF04560 http://pfam.xfam.org/family/PF04560 Pfam PF04561 http://pfam.xfam.org/family/PF04561 Pfam PF04563 http://pfam.xfam.org/family/PF04563 Pfam PF04565 http://pfam.xfam.org/family/PF04565 Pfam PF10385 http://pfam.xfam.org/family/PF10385 Phobius swissprot:RPOB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RPOB_ECOLI PhylomeDB P0A8V2 http://phylomedb.org/?seqid=P0A8V2 ProteinModelPortal P0A8V2 http://www.proteinmodelportal.org/query/uniprot/P0A8V2 PubMed 1095419 http://www.ncbi.nlm.nih.gov/pubmed/1095419 PubMed 1646077 http://www.ncbi.nlm.nih.gov/pubmed/1646077 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 19903881 http://www.ncbi.nlm.nih.gov/pubmed/19903881 PubMed 2068078 http://www.ncbi.nlm.nih.gov/pubmed/2068078 PubMed 21696463 http://www.ncbi.nlm.nih.gov/pubmed/21696463 PubMed 377281 http://www.ncbi.nlm.nih.gov/pubmed/377281 PubMed 6266829 http://www.ncbi.nlm.nih.gov/pubmed/6266829 PubMed 7011900 http://www.ncbi.nlm.nih.gov/pubmed/7011900 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_418414 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418414 RefSeq WP_000263098 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000263098 SMR P0A8V2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8V2 STRING 511145.b3987 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3987&targetmode=cogs STRING COG0085 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0085&targetmode=cogs SWISS-2DPAGE P0A8V2 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A8V2 TIGRFAMs TIGR02013 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02013 UniProtKB RPOB_ECOLI http://www.uniprot.org/uniprot/RPOB_ECOLI UniProtKB-AC P0A8V2 http://www.uniprot.org/uniprot/P0A8V2 charge swissprot:RPOB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RPOB_ECOLI eggNOG COG0085 http://eggnogapi.embl.de/nog_data/html/tree/COG0085 eggNOG ENOG4107QIH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QIH epestfind swissprot:RPOB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RPOB_ECOLI garnier swissprot:RPOB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RPOB_ECOLI helixturnhelix swissprot:RPOB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RPOB_ECOLI hmoment swissprot:RPOB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RPOB_ECOLI iep swissprot:RPOB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RPOB_ECOLI inforesidue swissprot:RPOB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RPOB_ECOLI octanol swissprot:RPOB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RPOB_ECOLI pepcoil swissprot:RPOB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RPOB_ECOLI pepdigest swissprot:RPOB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RPOB_ECOLI pepinfo swissprot:RPOB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RPOB_ECOLI pepnet swissprot:RPOB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RPOB_ECOLI pepstats swissprot:RPOB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RPOB_ECOLI pepwheel swissprot:RPOB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RPOB_ECOLI pepwindow swissprot:RPOB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RPOB_ECOLI sigcleave swissprot:RPOB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RPOB_ECOLI ## Database ID URL or Descriptions # AltName NADH flavin oxidoreductase # AltName RUTF_ECOLI FMN reductase # AltName RUTF_ECOLI NADH-flavin reductase RutF # BioGrid 4259548 7 # CATALYTIC ACTIVITY FMNH(2) + NAD(+) = FMN + NADH. {ECO:0000269|PubMed 20369853}. # DISRUPTION PHENOTYPE Cells lacking this gene fail to grow on uridine as the sole source of nitrogen at room temperature. {ECO:0000269|PubMed 20400551}. # EcoGene EG13854 rutF # FUNCTION RUTF_ECOLI Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway. In vitro, the flavin reductase Fre can substitute for the function of RutF, however, RutF is required for uracil utilization in vivo. {ECO 0000269|PubMed 16540542, ECO 0000269|PubMed 20400551}. # GO_function GO:0008752 FMN reductase activity; IEA:InterPro. # GO_function GO:0010181 FMN binding; IEA:InterPro. # GO_function GO:0042602 riboflavin reductase (NADPH) activity; IDA:UniProtKB. # GO_process GO:0006208 pyrimidine nucleobase catabolic process; IMP:EcoCyc. # GO_process GO:0006212 uracil catabolic process; IDA:UniProtKB. # GO_process GO:0019740 nitrogen utilization; IDA:UniProtKB. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 2.30.110.10 -; 1. # HAMAP MF_00833 RutF # INDUCTION RUTF_ECOLI Up-regulated by the nitrogen regulatory protein C (NtrC also called GlnG) and repressed by RutR. {ECO 0000269|PubMed 11121068, ECO 0000269|PubMed 17919280}. # InterPro IPR002563 Flavin_Rdtase-like_dom # InterPro IPR012349 Split_barrel_FMN-bd # InterPro IPR019917 RutF # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00240 Pyrimidine metabolism # MISCELLANEOUS RUTF_ECOLI The Rut pathway degrades exogenous pyrimidines as the sole nitrogen source at room temperature but not at 37 degrees Celsius, a restriction that is apparently a consequence of an inadequate ability to remove toxic malonic semialdehyde at the higher temperature (RutE/YdfG function). # Organism RUTF_ECOLI Escherichia coli (strain K12) # PATRIC 32117243 VBIEscCol129921_1045 # PIR E64842 E64842 # Pfam PF01613 Flavin_Reduct # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RUTF_ECOLI FMN reductase (NADH) RutF # RefSeq NP_415527 NC_000913.3 # RefSeq WP_001028083 NZ_LN832404.1 # SIMILARITY Belongs to the non-flavoprotein flavin reductase family. RutF subfamily. {ECO 0000305}. # SMART SM00903 Flavin_Reduct # SUPFAM SSF50475 SSF50475 # TIGRFAMs TIGR03615 RutF # eggNOG COG1853 LUCA # eggNOG ENOG4107YAQ Bacteria BLAST swissprot:RUTF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RUTF_ECOLI BioCyc ECOL316407:JW5138-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5138-MONOMER BioCyc EcoCyc:G6518-MONOMER http://biocyc.org/getid?id=EcoCyc:G6518-MONOMER BioCyc MetaCyc:G6518-MONOMER http://biocyc.org/getid?id=MetaCyc:G6518-MONOMER COG COG1853 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1853 DOI 10.1021/ja9107676 http://dx.doi.org/10.1021/ja9107676 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0600521103 http://dx.doi.org/10.1073/pnas.0600521103 DOI 10.1073/pnas.97.26.14674 http://dx.doi.org/10.1073/pnas.97.26.14674 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.2007.05954.x http://dx.doi.org/10.1111/j.1365-2958.2007.05954.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00201-10 http://dx.doi.org/10.1128/JB.00201-10 EC_number EC:1.5.1.42 http://www.genome.jp/dbget-bin/www_bget?EC:1.5.1.42 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.5.1.42 http://enzyme.expasy.org/EC/1.5.1.42 EchoBASE EB3614 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3614 EcoGene EG13854 http://www.ecogene.org/geneInfo.php?eg_id=EG13854 EnsemblBacteria AAC74092 http://www.ensemblgenomes.org/id/AAC74092 EnsemblBacteria AAC74092 http://www.ensemblgenomes.org/id/AAC74092 EnsemblBacteria BAA35774 http://www.ensemblgenomes.org/id/BAA35774 EnsemblBacteria BAA35774 http://www.ensemblgenomes.org/id/BAA35774 EnsemblBacteria BAA35774 http://www.ensemblgenomes.org/id/BAA35774 EnsemblBacteria b1007 http://www.ensemblgenomes.org/id/b1007 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008752 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008752 GO_function GO:0010181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010181 GO_function GO:0042602 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042602 GO_process GO:0006208 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006208 GO_process GO:0006212 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006212 GO_process GO:0019740 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019740 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 2.30.110.10 http://www.cathdb.info/version/latest/superfamily/2.30.110.10 GeneID 946594 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946594 HAMAP MF_00833 http://hamap.expasy.org/unirule/MF_00833 HOGENOM HOG000115783 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000115783&db=HOGENOM6 InParanoid P75893 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75893 IntEnz 1.5.1.42 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.5.1.42 InterPro IPR002563 http://www.ebi.ac.uk/interpro/entry/IPR002563 InterPro IPR012349 http://www.ebi.ac.uk/interpro/entry/IPR012349 InterPro IPR019917 http://www.ebi.ac.uk/interpro/entry/IPR019917 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5138 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5138 KEGG_Gene eco:b1007 http://www.genome.jp/dbget-bin/www_bget?eco:b1007 KEGG_Orthology KO:K09024 http://www.genome.jp/dbget-bin/www_bget?KO:K09024 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Reaction rn:R09936 http://www.genome.jp/dbget-bin/www_bget?rn:R09936 OMA WFDRGYH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WFDRGYH PSORT swissprot:RUTF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RUTF_ECOLI PSORT-B swissprot:RUTF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RUTF_ECOLI PSORT2 swissprot:RUTF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RUTF_ECOLI Pfam PF01613 http://pfam.xfam.org/family/PF01613 Phobius swissprot:RUTF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RUTF_ECOLI PhylomeDB P75893 http://phylomedb.org/?seqid=P75893 ProteinModelPortal P75893 http://www.proteinmodelportal.org/query/uniprot/P75893 PubMed 11121068 http://www.ncbi.nlm.nih.gov/pubmed/11121068 PubMed 16540542 http://www.ncbi.nlm.nih.gov/pubmed/16540542 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17919280 http://www.ncbi.nlm.nih.gov/pubmed/17919280 PubMed 20369853 http://www.ncbi.nlm.nih.gov/pubmed/20369853 PubMed 20400551 http://www.ncbi.nlm.nih.gov/pubmed/20400551 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415527 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415527 RefSeq WP_001028083 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001028083 SMART SM00903 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00903 SMR P75893 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75893 STRING 511145.b1007 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1007&targetmode=cogs STRING COG1853 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1853&targetmode=cogs SUPFAM SSF50475 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50475 TIGRFAMs TIGR03615 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03615 UniProtKB RUTF_ECOLI http://www.uniprot.org/uniprot/RUTF_ECOLI UniProtKB-AC P75893 http://www.uniprot.org/uniprot/P75893 charge swissprot:RUTF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RUTF_ECOLI eggNOG COG1853 http://eggnogapi.embl.de/nog_data/html/tree/COG1853 eggNOG ENOG4107YAQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107YAQ epestfind swissprot:RUTF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RUTF_ECOLI garnier swissprot:RUTF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RUTF_ECOLI helixturnhelix swissprot:RUTF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RUTF_ECOLI hmoment swissprot:RUTF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RUTF_ECOLI iep swissprot:RUTF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RUTF_ECOLI inforesidue swissprot:RUTF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RUTF_ECOLI octanol swissprot:RUTF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RUTF_ECOLI pepcoil swissprot:RUTF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RUTF_ECOLI pepdigest swissprot:RUTF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RUTF_ECOLI pepinfo swissprot:RUTF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RUTF_ECOLI pepnet swissprot:RUTF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RUTF_ECOLI pepstats swissprot:RUTF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RUTF_ECOLI pepwheel swissprot:RUTF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RUTF_ECOLI pepwindow swissprot:RUTF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RUTF_ECOLI sigcleave swissprot:RUTF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RUTF_ECOLI ## Database ID URL or Descriptions # AltName PYRD_ECOLI DHOdehase # AltName PYRD_ECOLI Dihydroorotate oxidase # BIOPHYSICOCHEMICAL PROPERTIES PYRD_ECOLI Kinetic parameters KM=28.8 uM for dihydroorotate {ECO 0000269|PubMed 10074342}; Vmax=180 umol/min/mg enzyme {ECO 0000269|PubMed 10074342}; # BRENDA 1.3.5 2026 # BioGrid 4259440 19 # CATALYTIC ACTIVITY (S)-dihydroorotate + a quinone = orotate + a quinol. {ECO:0000269|PubMed 10074342}. # CDD cd04738 DHOD_2_like # COFACTOR PYRD_ECOLI Name=FMN; Xref=ChEBI CHEBI 58210; Evidence={ECO 0000269|PubMed 12220493}; Note=Binds 1 FMN per subunit. {ECO 0000269|PubMed 12220493}; # EcoGene EG10807 pyrD # FUNCTION PYRD_ECOLI Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. {ECO 0000269|PubMed 10074342}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016020 membrane; IDA:EcoCyc. # GO_function GO:0004152 dihydroorotate dehydrogenase activity; IDA:EcoCyc. # GO_function GO:0010181 FMN binding; IDA:EcoCyc. # GO_process GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process; IMP:EcoCyc. # GO_process GO:0044205 'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.70 -; 1. # HAMAP MF_00225 DHO_dh_type2 # IntAct P0A7E1 6 # InterPro IPR001295 Dihydroorotate_DH_CS # InterPro IPR005719 Dihydroorotate_DH_2 # InterPro IPR005720 Dihydroorotate_DH # InterPro IPR012135 Dihydroorotate_DH_1_2 # InterPro IPR013785 Aldolase_TIM # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00240 Pyrimidine metabolism # Organism PYRD_ECOLI Escherichia coli (strain K12) # PATHWAY Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route) step 1/1. # PATRIC 32117109 VBIEscCol129921_0979 # PDB 1F76 X-ray; 2.50 A; A/B/D/E=1-336 # PIR A23109 DEECDO # PIRSF PIRSF000164 DHO_oxidase # PROSITE PS00911 DHODEHASE_1 # PROSITE PS00912 DHODEHASE_2 # Pfam PF01180 DHO_dh # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PYRD_ECOLI Dihydroorotate dehydrogenase (quinone) # RefSeq NP_415465 NC_000913.3 # RefSeq WP_001295352 NZ_LN832404.1 # SIMILARITY Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION PYRD_ECOLI Cell membrane; Peripheral membrane protein. # SUBUNIT Monomer. {ECO:0000269|PubMed 12220493}. # TIGRFAMs TIGR01036 pyrD_sub2 # UniPathway UPA00070 UER00946 # eggNOG COG0167 LUCA # eggNOG ENOG4107QYT Bacteria BLAST swissprot:PYRD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PYRD_ECOLI BioCyc ECOL316407:JW0928-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0928-MONOMER BioCyc EcoCyc:DIHYDROOROTOX-MONOMER http://biocyc.org/getid?id=EcoCyc:DIHYDROOROTOX-MONOMER BioCyc MetaCyc:DIHYDROOROTOX-MONOMER http://biocyc.org/getid?id=MetaCyc:DIHYDROOROTOX-MONOMER COG COG0167 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0167 DIP DIP-35945N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35945N DOI 10.1016/S0969-2126(02)00831-6 http://dx.doi.org/10.1016/S0969-2126(02)00831-6 DOI 10.1021/bi982352c http://dx.doi.org/10.1021/bi982352c DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1432-1033.1985.tb09068.x http://dx.doi.org/10.1111/j.1432-1033.1985.tb09068.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.3.5.2 http://www.genome.jp/dbget-bin/www_bget?EC:1.3.5.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X02826 http://www.ebi.ac.uk/ena/data/view/X02826 ENZYME 1.3.5.2 http://enzyme.expasy.org/EC/1.3.5.2 EchoBASE EB0800 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0800 EcoGene EG10807 http://www.ecogene.org/geneInfo.php?eg_id=EG10807 EnsemblBacteria AAC74031 http://www.ensemblgenomes.org/id/AAC74031 EnsemblBacteria AAC74031 http://www.ensemblgenomes.org/id/AAC74031 EnsemblBacteria BAA35700 http://www.ensemblgenomes.org/id/BAA35700 EnsemblBacteria BAA35700 http://www.ensemblgenomes.org/id/BAA35700 EnsemblBacteria BAA35700 http://www.ensemblgenomes.org/id/BAA35700 EnsemblBacteria b0945 http://www.ensemblgenomes.org/id/b0945 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0004152 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004152 GO_function GO:0010181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010181 GO_process GO:0006207 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006207 GO_process GO:0044205 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044205 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 945556 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945556 HAMAP MF_00225 http://hamap.expasy.org/unirule/MF_00225 HOGENOM HOG000225103 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000225103&db=HOGENOM6 InParanoid P0A7E1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7E1 IntAct P0A7E1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7E1* IntEnz 1.3.5.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.3.5.2 InterPro IPR001295 http://www.ebi.ac.uk/interpro/entry/IPR001295 InterPro IPR005719 http://www.ebi.ac.uk/interpro/entry/IPR005719 InterPro IPR005720 http://www.ebi.ac.uk/interpro/entry/IPR005720 InterPro IPR012135 http://www.ebi.ac.uk/interpro/entry/IPR012135 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0928 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0928 KEGG_Gene eco:b0945 http://www.genome.jp/dbget-bin/www_bget?eco:b0945 KEGG_Orthology KO:K00226 http://www.genome.jp/dbget-bin/www_bget?KO:K00226 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Reaction rn:R01867 http://www.genome.jp/dbget-bin/www_bget?rn:R01867 OMA ERIKMGA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ERIKMGA PDB 1F76 http://www.ebi.ac.uk/pdbe-srv/view/entry/1F76 PDBsum 1F76 http://www.ebi.ac.uk/pdbsum/1F76 PROSITE PS00911 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00911 PROSITE PS00912 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00912 PSORT swissprot:PYRD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PYRD_ECOLI PSORT-B swissprot:PYRD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PYRD_ECOLI PSORT2 swissprot:PYRD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PYRD_ECOLI Pfam PF01180 http://pfam.xfam.org/family/PF01180 Phobius swissprot:PYRD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PYRD_ECOLI PhylomeDB P0A7E1 http://phylomedb.org/?seqid=P0A7E1 ProteinModelPortal P0A7E1 http://www.proteinmodelportal.org/query/uniprot/P0A7E1 PubMed 10074342 http://www.ncbi.nlm.nih.gov/pubmed/10074342 PubMed 12220493 http://www.ncbi.nlm.nih.gov/pubmed/12220493 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2992959 http://www.ncbi.nlm.nih.gov/pubmed/2992959 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415465 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415465 RefSeq WP_001295352 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295352 SMR P0A7E1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7E1 STRING 511145.b0945 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0945&targetmode=cogs STRING COG0167 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0167&targetmode=cogs SWISS-2DPAGE P0A7E1 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A7E1 TIGRFAMs TIGR01036 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01036 UniProtKB PYRD_ECOLI http://www.uniprot.org/uniprot/PYRD_ECOLI UniProtKB-AC P0A7E1 http://www.uniprot.org/uniprot/P0A7E1 charge swissprot:PYRD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PYRD_ECOLI eggNOG COG0167 http://eggnogapi.embl.de/nog_data/html/tree/COG0167 eggNOG ENOG4107QYT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QYT epestfind swissprot:PYRD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PYRD_ECOLI garnier swissprot:PYRD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PYRD_ECOLI helixturnhelix swissprot:PYRD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PYRD_ECOLI hmoment swissprot:PYRD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PYRD_ECOLI iep swissprot:PYRD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PYRD_ECOLI inforesidue swissprot:PYRD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PYRD_ECOLI octanol swissprot:PYRD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PYRD_ECOLI pepcoil swissprot:PYRD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PYRD_ECOLI pepdigest swissprot:PYRD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PYRD_ECOLI pepinfo swissprot:PYRD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PYRD_ECOLI pepnet swissprot:PYRD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PYRD_ECOLI pepstats swissprot:PYRD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PYRD_ECOLI pepwheel swissprot:PYRD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PYRD_ECOLI pepwindow swissprot:PYRD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PYRD_ECOLI sigcleave swissprot:PYRD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PYRD_ECOLI ## Database ID URL or Descriptions # EcoGene EG14355 ylcH # MISCELLANEOUS YLCH_ECOLI Encoded by the cryptic lambdoid prophage DLP12. # Organism YLCH_ECOLI Escherichia coli (strain K12) # PIR S66586 S66586 # Proteomes UP000000625 Chromosome # RecName YLCH_ECOLI Uncharacterized protein YlcH # RefSeq YP_001165308 NC_000913.3 # SIMILARITY To equivalent protein in phage 82. {ECO 0000305}. BLAST swissprot:YLCH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YLCH_ECOLI BioCyc EcoCyc:MONOMER0-2813 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2813 DOI 10.1006/jmbi.1996.0185 http://dx.doi.org/10.1006/jmbi.1996.0185 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X92587 http://www.ebi.ac.uk/ena/data/view/X92587 EcoGene EG14355 http://www.ecogene.org/geneInfo.php?eg_id=EG14355 EnsemblBacteria ABP93435 http://www.ensemblgenomes.org/id/ABP93435 EnsemblBacteria ABP93435 http://www.ensemblgenomes.org/id/ABP93435 EnsemblBacteria b4588 http://www.ensemblgenomes.org/id/b4588 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 5061504 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5061504 KEGG_Gene eco:b4588 http://www.genome.jp/dbget-bin/www_bget?eco:b4588 PSORT swissprot:YLCH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YLCH_ECOLI PSORT-B swissprot:YLCH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YLCH_ECOLI PSORT2 swissprot:YLCH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YLCH_ECOLI Phobius swissprot:YLCH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YLCH_ECOLI ProteinModelPortal Q47268 http://www.proteinmodelportal.org/query/uniprot/Q47268 PubMed 8648624 http://www.ncbi.nlm.nih.gov/pubmed/8648624 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq YP_001165308 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001165308 STRING 511145.b4588 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4588&targetmode=cogs UniProtKB YLCH_ECOLI http://www.uniprot.org/uniprot/YLCH_ECOLI UniProtKB-AC Q47268 http://www.uniprot.org/uniprot/Q47268 charge swissprot:YLCH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YLCH_ECOLI epestfind swissprot:YLCH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YLCH_ECOLI garnier swissprot:YLCH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YLCH_ECOLI helixturnhelix swissprot:YLCH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YLCH_ECOLI hmoment swissprot:YLCH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YLCH_ECOLI iep swissprot:YLCH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YLCH_ECOLI inforesidue swissprot:YLCH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YLCH_ECOLI octanol swissprot:YLCH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YLCH_ECOLI pepcoil swissprot:YLCH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YLCH_ECOLI pepdigest swissprot:YLCH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YLCH_ECOLI pepinfo swissprot:YLCH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YLCH_ECOLI pepnet swissprot:YLCH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YLCH_ECOLI pepstats swissprot:YLCH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YLCH_ECOLI pepwheel swissprot:YLCH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YLCH_ECOLI pepwindow swissprot:YLCH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YLCH_ECOLI sigcleave swissprot:YLCH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YLCH_ECOLI ## Database ID URL or Descriptions # BioGrid 4262364 264 # EcoGene EG13018 yqhH # GO_component GO:0009279 cell outer membrane; IEA:UniProtKB-SubCell. # GOslim_component GO:0005575 cellular_component # IntAct P65298 2 # InterPro IPR006817 Lipoprotein_leucine-zipper_dom # InterPro IPR016367 Murein-lipoprotein # Organism YQHH_ECOLI Escherichia coli (strain K12) # PATRIC 32121444 VBIEscCol129921_3109 # PIR D65088 D65088 # PIRSF PIRSF002855 Murein-lipoprotein # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF04728 LPP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQHH_ECOLI Uncharacterized lipoprotein YqhH # RefSeq NP_417487 NC_000913.3 # RefSeq WP_000848528 NZ_LN832404.1 # SUBCELLULAR LOCATION YQHH_ECOLI Cell outer membrane {ECO 0000250|UniProtKB P69776}; Lipid-anchor {ECO 0000250|UniProtKB P69776}. Cell outer membrane {ECO 0000250|UniProtKB P69776}; Peptidoglycan-anchor {ECO 0000250|UniProtKB P69776}. # eggNOG COG4238 LUCA BLAST swissprot:YQHH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQHH_ECOLI BioCyc ECOL316407:JW2982-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2982-MONOMER BioCyc EcoCyc:G7567-MONOMER http://biocyc.org/getid?id=EcoCyc:G7567-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2837 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2837 EcoGene EG13018 http://www.ecogene.org/geneInfo.php?eg_id=EG13018 EnsemblBacteria AAC76050 http://www.ensemblgenomes.org/id/AAC76050 EnsemblBacteria AAC76050 http://www.ensemblgenomes.org/id/AAC76050 EnsemblBacteria BAE77071 http://www.ensemblgenomes.org/id/BAE77071 EnsemblBacteria BAE77071 http://www.ensemblgenomes.org/id/BAE77071 EnsemblBacteria BAE77071 http://www.ensemblgenomes.org/id/BAE77071 EnsemblBacteria b3014 http://www.ensemblgenomes.org/id/b3014 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GeneID 946832 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946832 HOGENOM HOG000295473 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000295473&db=HOGENOM6 IntAct P65298 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P65298* InterPro IPR006817 http://www.ebi.ac.uk/interpro/entry/IPR006817 InterPro IPR016367 http://www.ebi.ac.uk/interpro/entry/IPR016367 KEGG_Gene ecj:JW2982 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2982 KEGG_Gene eco:b3014 http://www.genome.jp/dbget-bin/www_bget?eco:b3014 OMA CASTTKI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CASTTKI PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YQHH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQHH_ECOLI PSORT-B swissprot:YQHH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQHH_ECOLI PSORT2 swissprot:YQHH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQHH_ECOLI Pfam PF04728 http://pfam.xfam.org/family/PF04728 Phobius swissprot:YQHH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQHH_ECOLI ProteinModelPortal P65298 http://www.proteinmodelportal.org/query/uniprot/P65298 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417487 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417487 RefSeq WP_000848528 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000848528 SMR P65298 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P65298 STRING 511145.b3014 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3014&targetmode=cogs UniProtKB YQHH_ECOLI http://www.uniprot.org/uniprot/YQHH_ECOLI UniProtKB-AC P65298 http://www.uniprot.org/uniprot/P65298 charge swissprot:YQHH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQHH_ECOLI eggNOG COG4238 http://eggnogapi.embl.de/nog_data/html/tree/COG4238 epestfind swissprot:YQHH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQHH_ECOLI garnier swissprot:YQHH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQHH_ECOLI helixturnhelix swissprot:YQHH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQHH_ECOLI hmoment swissprot:YQHH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQHH_ECOLI iep swissprot:YQHH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQHH_ECOLI inforesidue swissprot:YQHH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQHH_ECOLI octanol swissprot:YQHH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQHH_ECOLI pepcoil swissprot:YQHH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQHH_ECOLI pepdigest swissprot:YQHH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQHH_ECOLI pepinfo swissprot:YQHH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQHH_ECOLI pepnet swissprot:YQHH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQHH_ECOLI pepstats swissprot:YQHH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQHH_ECOLI pepwheel swissprot:YQHH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQHH_ECOLI pepwindow swissprot:YQHH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQHH_ECOLI sigcleave swissprot:YQHH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQHH_ECOLI ## Database ID URL or Descriptions # BioGrid 4261747 6 # EcoGene EG12827 yhdP # InterPro IPR011836 CHP02099 # InterPro IPR025263 DUF3971 # InterPro IPR032712 AsmA_C # Organism YHDP_ECOLI Escherichia coli (strain K12) # PATRIC 32121918 VBIEscCol129921_3343 # PIR G65116 G65116 # PIR H65116 H65116 # Pfam PF13116 DUF3971 # Pfam PF13502 AsmA_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHDP_ECOLI Uncharacterized protein YhdP # RefSeq WP_001253618 NZ_LN832404.1 # RefSeq YP_026208 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA58047.1; Type=Frameshift; Positions=265, 736; Note=Produces three separate ORFs (yhdP, yhdQ and yhdR).; Evidence={ECO:0000305}; Sequence=AAA58048.1; Type=Frameshift; Positions=265, 736; Note=Produces three separate ORFs (yhdP, yhdQ and yhdR).; Evidence={ECO 0000305}; Sequence=AAA58049.1; Type=Frameshift; Positions=265, 736; Note=Produces three separate ORFs (yhdP, yhdQ and yhdR).; Evidence={ECO:0000305}; # TIGRFAMs TIGR02099 TIGR02099 # eggNOG COG3164 LUCA # eggNOG ENOG4105QD6 Bacteria BLAST swissprot:YHDP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHDP_ECOLI BioCyc ECOL316407:JW5542-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5542-MONOMER BioCyc EcoCyc:G7690-MONOMER http://biocyc.org/getid?id=EcoCyc:G7690-MONOMER DIP DIP-12299N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12299N DOI 10.1016/0378-1119(91)90578-Y http://dx.doi.org/10.1016/0378-1119(91)90578-Y DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X57166 http://www.ebi.ac.uk/ena/data/view/X57166 EchoBASE EB2678 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2678 EcoGene EG12827 http://www.ecogene.org/geneInfo.php?eg_id=EG12827 EnsemblBacteria AAT48173 http://www.ensemblgenomes.org/id/AAT48173 EnsemblBacteria AAT48173 http://www.ensemblgenomes.org/id/AAT48173 EnsemblBacteria BAE77288 http://www.ensemblgenomes.org/id/BAE77288 EnsemblBacteria BAE77288 http://www.ensemblgenomes.org/id/BAE77288 EnsemblBacteria BAE77288 http://www.ensemblgenomes.org/id/BAE77288 EnsemblBacteria b4472 http://www.ensemblgenomes.org/id/b4472 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 2847740 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2847740 HOGENOM HOG000125283 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125283&db=HOGENOM6 InParanoid P46474 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P46474 IntAct P46474 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P46474* InterPro IPR011836 http://www.ebi.ac.uk/interpro/entry/IPR011836 InterPro IPR025263 http://www.ebi.ac.uk/interpro/entry/IPR025263 InterPro IPR032712 http://www.ebi.ac.uk/interpro/entry/IPR032712 KEGG_Gene ecj:JW5542 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5542 KEGG_Gene eco:b4472 http://www.genome.jp/dbget-bin/www_bget?eco:b4472 MINT MINT-1261114 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1261114 OMA SLPQSDW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SLPQSDW PSORT swissprot:YHDP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHDP_ECOLI PSORT-B swissprot:YHDP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHDP_ECOLI PSORT2 swissprot:YHDP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHDP_ECOLI Pfam PF13116 http://pfam.xfam.org/family/PF13116 Pfam PF13502 http://pfam.xfam.org/family/PF13502 Phobius swissprot:YHDP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHDP_ECOLI ProteinModelPortal P46474 http://www.proteinmodelportal.org/query/uniprot/P46474 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1937035 http://www.ncbi.nlm.nih.gov/pubmed/1937035 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001253618 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001253618 RefSeq YP_026208 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026208 SMR P46474 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P46474 STRING 511145.b4472 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4472&targetmode=cogs TIGRFAMs TIGR02099 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02099 UniProtKB YHDP_ECOLI http://www.uniprot.org/uniprot/YHDP_ECOLI UniProtKB-AC P46474 http://www.uniprot.org/uniprot/P46474 charge swissprot:YHDP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHDP_ECOLI eggNOG COG3164 http://eggnogapi.embl.de/nog_data/html/tree/COG3164 eggNOG ENOG4105QD6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105QD6 epestfind swissprot:YHDP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHDP_ECOLI garnier swissprot:YHDP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHDP_ECOLI helixturnhelix swissprot:YHDP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHDP_ECOLI hmoment swissprot:YHDP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHDP_ECOLI iep swissprot:YHDP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHDP_ECOLI inforesidue swissprot:YHDP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHDP_ECOLI octanol swissprot:YHDP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHDP_ECOLI pepcoil swissprot:YHDP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHDP_ECOLI pepdigest swissprot:YHDP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHDP_ECOLI pepinfo swissprot:YHDP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHDP_ECOLI pepnet swissprot:YHDP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHDP_ECOLI pepstats swissprot:YHDP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHDP_ECOLI pepwheel swissprot:YHDP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHDP_ECOLI pepwindow swissprot:YHDP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHDP_ECOLI sigcleave swissprot:YHDP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHDP_ECOLI ## Database ID URL or Descriptions # AltName CCDA_ECOLI LynA # AltName CCDA_ECOLI Protein H # AltName CCDA_ECOLI Protein LetA # DISRUPTION PHENOTYPE CCDA_ECOLI Leads to cell death and induction of the SOS pathway. Additional disruption of ccdB reverses this effect, i.e. no cell death nor induction of the SOS response. The double disruption leads to increased plasmid loss. {ECO 0000269|PubMed 6227479, ECO 0000269|PubMed 6308648}. # FUNCTION CCDA_ECOLI Antitoxin component of a toxin-antitoxin (TA) module which inhibits the post-segregational killing (PSK) of plasmid- free cells, also referred to as a plasmid addiction system. Labile antitoxin with a half-life of about 1 hour in the presence of CcdB. Binds to and blocks the activity of CcdB; will also remove bound CcdB protein from the CcdB-GyrA complex by forming a CcdA- CcdB complex, a process termed rejuvenation. The N-terminal 36 residues are not required for rejuventation. Functions as a transcriptional corepressor for the ccdAB operon, repression also requires CcdB. {ECO 0000269|PubMed 1324324, ECO 0000269|PubMed 19647513, ECO 0000269|PubMed 2615761, ECO 0000269|PubMed 2651399, ECO 0000269|PubMed 6308648, ECO 0000269|PubMed 6327993, ECO 0000269|PubMed 8604132}. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # InterPro IPR009956 Post-segregation_anti-tox_CcdA # Organism CCDA_ECOLI Escherichia coli (strain K12) # PDB 2ADL NMR; -; A/B=1-72 # PDB 2ADN NMR; -; A/B=1-72 # PDB 2H3A NMR; -; A/B=1-72 # PDB 2H3C NMR; -; A/B=1-72 # PDB 3G7Z X-ray; 2.35 A; C/D=37-72 # PDB 3HPW X-ray; 1.45 A; C=37-72 # PIR T00237 T00237 # PTM CCDA_ECOLI Degraded by the Lon protease. # Pfam PF07362 CcdA # RecName CCDA_ECOLI Antitoxin CcdA # RefSeq NP_061421 NC_002483.1 # RefSeq WP_000813634 NZ_CP014273.1 # RefSeq YP_001816480 NC_010558.1 # RefSeq YP_003108266 NC_013122.1 # RefSeq YP_003162544 NC_013175.1 # RefSeq YP_003829105 NC_014384.1 # RefSeq YP_003829230 NC_014385.1 # RefSeq YP_006940499 NC_019000.1 # RefSeq YP_424850 NC_007635.1 # RefSeq YP_788019 NC_008460.1 # SIMILARITY Belongs to the CcdA antitoxin family. {ECO 0000305}. # SUBUNIT CCDA_ECOLI Homodimer in solution and when bound to DNA. Three CcdA homodimers bind to the promoter region and contact each other via Val-22. Forms a complex with toxin CcdB; there are both high- and low-affinity binding sites for CcdA such that both CcdA-CcdB(2) and CcdA(2)CcdB(2) complexes can form. The CcdA-CcdB(2) trimer is sufficient for rejuvenation, whereas maximal operon repression occurs with CcdA(2)CcdB(2). When the CcdA CcdB ratio is lower than 1, a CcdA(2)-CcdB(4) complex is formed which is devoid of repression activity. In this case repression is alleviated and both proteins are produced. {ECO 0000269|PubMed 17007877, ECO 0000269|PubMed 19647513, ECO 0000269|PubMed 2615761, ECO 0000269|PubMed 2651399, ECO 0000269|PubMed 8604132}. BLAST swissprot:CCDA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CCDA_ECOLI DOI 10.1006/jmbi.1993.1609 http://dx.doi.org/10.1006/jmbi.1993.1609 DOI 10.1006/jmbi.1996.0102 http://dx.doi.org/10.1006/jmbi.1996.0102 DOI 10.1007/BF00261153 http://dx.doi.org/10.1007/BF00261153 DOI 10.1016/0022-2836(84)90086-X http://dx.doi.org/10.1016/0022-2836(84)90086-X DOI 10.1016/0022-2836(92)90629-X http://dx.doi.org/10.1016/0022-2836(92)90629-X DOI 10.1016/j.jmb.2006.08.082 http://dx.doi.org/10.1016/j.jmb.2006.08.082 DOI 10.1016/j.molcel.2009.05.025 http://dx.doi.org/10.1016/j.molcel.2009.05.025 DOI 10.1046/j.1365-2958.2001.02492.x http://dx.doi.org/10.1046/j.1365-2958.2001.02492.x DOI 10.1073/pnas.80.15.4784 http://dx.doi.org/10.1073/pnas.80.15.4784 DOI 10.1111/j.1365-2958.1994.tb00391.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb00391.x EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL M12987 http://www.ebi.ac.uk/ena/data/view/M12987 EMBL X00594 http://www.ebi.ac.uk/ena/data/view/X00594 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 1263592 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263592 GeneID 13877456 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13877456 GeneID 3829331 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3829331 GeneID 4364200 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4364200 GeneID 6275968 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6275968 GeneID 8319311 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8319311 GeneID 8381891 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8381891 GeneID 9538036 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9538036 GeneID 9538167 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9538167 InterPro IPR009956 http://www.ebi.ac.uk/interpro/entry/IPR009956 OMA HNNIYLY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HNNIYLY PDB 2ADL http://www.ebi.ac.uk/pdbe-srv/view/entry/2ADL PDB 2ADN http://www.ebi.ac.uk/pdbe-srv/view/entry/2ADN PDB 2H3A http://www.ebi.ac.uk/pdbe-srv/view/entry/2H3A PDB 2H3C http://www.ebi.ac.uk/pdbe-srv/view/entry/2H3C PDB 3G7Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3G7Z PDB 3HPW http://www.ebi.ac.uk/pdbe-srv/view/entry/3HPW PDBsum 2ADL http://www.ebi.ac.uk/pdbsum/2ADL PDBsum 2ADN http://www.ebi.ac.uk/pdbsum/2ADN PDBsum 2H3A http://www.ebi.ac.uk/pdbsum/2H3A PDBsum 2H3C http://www.ebi.ac.uk/pdbsum/2H3C PDBsum 3G7Z http://www.ebi.ac.uk/pdbsum/3G7Z PDBsum 3HPW http://www.ebi.ac.uk/pdbsum/3HPW PSORT swissprot:CCDA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CCDA_ECOLI PSORT-B swissprot:CCDA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CCDA_ECOLI PSORT2 swissprot:CCDA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CCDA_ECOLI Pfam PF07362 http://pfam.xfam.org/family/PF07362 Phobius swissprot:CCDA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CCDA_ECOLI ProteinModelPortal P62552 http://www.proteinmodelportal.org/query/uniprot/P62552 PubMed 11454201 http://www.ncbi.nlm.nih.gov/pubmed/11454201 PubMed 1324324 http://www.ncbi.nlm.nih.gov/pubmed/1324324 PubMed 17007877 http://www.ncbi.nlm.nih.gov/pubmed/17007877 PubMed 19647513 http://www.ncbi.nlm.nih.gov/pubmed/19647513 PubMed 2615761 http://www.ncbi.nlm.nih.gov/pubmed/2615761 PubMed 2651399 http://www.ncbi.nlm.nih.gov/pubmed/2651399 PubMed 6227479 http://www.ncbi.nlm.nih.gov/pubmed/6227479 PubMed 6308648 http://www.ncbi.nlm.nih.gov/pubmed/6308648 PubMed 6327993 http://www.ncbi.nlm.nih.gov/pubmed/6327993 PubMed 8022284 http://www.ncbi.nlm.nih.gov/pubmed/8022284 PubMed 8254658 http://www.ncbi.nlm.nih.gov/pubmed/8254658 PubMed 8604132 http://www.ncbi.nlm.nih.gov/pubmed/8604132 RefSeq NP_061421 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061421 RefSeq WP_000813634 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000813634 RefSeq YP_001816480 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001816480 RefSeq YP_003108266 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_003108266 RefSeq YP_003162544 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_003162544 RefSeq YP_003829105 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_003829105 RefSeq YP_003829230 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_003829230 RefSeq YP_006940499 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_006940499 RefSeq YP_424850 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_424850 RefSeq YP_788019 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_788019 SMR P62552 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P62552 UniProtKB CCDA_ECOLI http://www.uniprot.org/uniprot/CCDA_ECOLI UniProtKB-AC P62552 http://www.uniprot.org/uniprot/P62552 charge swissprot:CCDA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CCDA_ECOLI epestfind swissprot:CCDA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CCDA_ECOLI garnier swissprot:CCDA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CCDA_ECOLI helixturnhelix swissprot:CCDA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CCDA_ECOLI hmoment swissprot:CCDA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CCDA_ECOLI iep swissprot:CCDA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CCDA_ECOLI inforesidue swissprot:CCDA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CCDA_ECOLI octanol swissprot:CCDA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CCDA_ECOLI pepcoil swissprot:CCDA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CCDA_ECOLI pepdigest swissprot:CCDA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CCDA_ECOLI pepinfo swissprot:CCDA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CCDA_ECOLI pepnet swissprot:CCDA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CCDA_ECOLI pepstats swissprot:CCDA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CCDA_ECOLI pepwheel swissprot:CCDA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CCDA_ECOLI pepwindow swissprot:CCDA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CCDA_ECOLI sigcleave swissprot:CCDA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CCDA_ECOLI ## Database ID URL or Descriptions # BioGrid 4263373 13 # CDD cd07377 WHTH_GntR # EcoGene EG11718 dgoR # FUNCTION DGOR_ECOLI Repressor for the dgoRKAT operon. Binds D-galactonate as an inducer. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; ISS:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # Gene3D 1.20.120.530 -; 1. # InterPro IPR000524 Tscrpt_reg_HTH_GntR # InterPro IPR008920 TF_FadR/GntR_C # InterPro IPR011711 GntR_C # InterPro IPR011991 WHTH_DNA-bd_dom # Organism DGOR_ECOLI Escherichia coli (strain K12) # PATRIC 32122885 VBIEscCol129921_3818 # PRINTS PR00035 HTHGNTR # PROSITE PS50949 HTH_GNTR # Pfam PF00392 GntR # Pfam PF07729 FCD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DGOR_ECOLI Galactonate operon transcriptional repressor # RefSeq WP_000174305 NZ_LN832404.1 # RefSeq YP_026239 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA62046.1; Type=Frameshift; Positions=174; Evidence={ECO 0000305}; # SIMILARITY Contains 1 HTH gntR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00307}. # SMART SM00345 HTH_GNTR # SMART SM00895 FCD # SUPFAM SSF46785 SSF46785 # SUPFAM SSF48008 SSF48008 # eggNOG COG2186 LUCA # eggNOG ENOG4105EMF Bacteria BLAST swissprot:DGOR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DGOR_ECOLI BioCyc ECOL316407:JW5627-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5627-MONOMER BioCyc EcoCyc:G7790-MONOMER http://biocyc.org/getid?id=EcoCyc:G7790-MONOMER DIP DIP-9435N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9435N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1669 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1669 EcoGene EG11718 http://www.ecogene.org/geneInfo.php?eg_id=EG11718 EnsemblBacteria AAT48199 http://www.ensemblgenomes.org/id/AAT48199 EnsemblBacteria AAT48199 http://www.ensemblgenomes.org/id/AAT48199 EnsemblBacteria BAE77599 http://www.ensemblgenomes.org/id/BAE77599 EnsemblBacteria BAE77599 http://www.ensemblgenomes.org/id/BAE77599 EnsemblBacteria BAE77599 http://www.ensemblgenomes.org/id/BAE77599 EnsemblBacteria b4479 http://www.ensemblgenomes.org/id/b4479 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 1.20.120.530 http://www.cathdb.info/version/latest/superfamily/1.20.120.530 GeneID 2847767 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2847767 HOGENOM HOG000273996 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000273996&db=HOGENOM6 InParanoid P31460 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31460 InterPro IPR000524 http://www.ebi.ac.uk/interpro/entry/IPR000524 InterPro IPR008920 http://www.ebi.ac.uk/interpro/entry/IPR008920 InterPro IPR011711 http://www.ebi.ac.uk/interpro/entry/IPR011711 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW5627 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5627 KEGG_Gene eco:b4479 http://www.genome.jp/dbget-bin/www_bget?eco:b4479 OMA AAHEIND http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AAHEIND PRINTS PR00035 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00035 PROSITE PS50949 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50949 PSORT swissprot:DGOR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DGOR_ECOLI PSORT-B swissprot:DGOR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DGOR_ECOLI PSORT2 swissprot:DGOR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DGOR_ECOLI Pfam PF00392 http://pfam.xfam.org/family/PF00392 Pfam PF07729 http://pfam.xfam.org/family/PF07729 Phobius swissprot:DGOR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DGOR_ECOLI PhylomeDB P31460 http://phylomedb.org/?seqid=P31460 ProteinModelPortal P31460 http://www.proteinmodelportal.org/query/uniprot/P31460 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000174305 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000174305 RefSeq YP_026239 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026239 SMART SM00345 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00345 SMART SM00895 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00895 SMR P31460 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31460 STRING 511145.b4479 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4479&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SUPFAM SSF48008 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48008 UniProtKB DGOR_ECOLI http://www.uniprot.org/uniprot/DGOR_ECOLI UniProtKB-AC P31460 http://www.uniprot.org/uniprot/P31460 charge swissprot:DGOR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DGOR_ECOLI eggNOG COG2186 http://eggnogapi.embl.de/nog_data/html/tree/COG2186 eggNOG ENOG4105EMF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EMF epestfind swissprot:DGOR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DGOR_ECOLI garnier swissprot:DGOR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DGOR_ECOLI helixturnhelix swissprot:DGOR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DGOR_ECOLI hmoment swissprot:DGOR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DGOR_ECOLI iep swissprot:DGOR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DGOR_ECOLI inforesidue swissprot:DGOR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DGOR_ECOLI octanol swissprot:DGOR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DGOR_ECOLI pepcoil swissprot:DGOR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DGOR_ECOLI pepdigest swissprot:DGOR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DGOR_ECOLI pepinfo swissprot:DGOR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DGOR_ECOLI pepnet swissprot:DGOR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DGOR_ECOLI pepstats swissprot:DGOR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DGOR_ECOLI pepwheel swissprot:DGOR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DGOR_ECOLI pepwindow swissprot:DGOR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DGOR_ECOLI sigcleave swissprot:DGOR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DGOR_ECOLI ## Database ID URL or Descriptions # BioGrid 4260109 17 # EcoGene EG11533 ychH # GO_process GO:0044011 single-species biofilm formation on inanimate substrate; IMP:EcoCyc. # GO_process GO:0070301 cellular response to hydrogen peroxide; IMP:EcoCyc. # GO_process GO:0071276 cellular response to cadmium ion; IMP:EcoCyc. # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # InterPro IPR019698 DUF2583 # Organism YCHH_ECOLI Escherichia coli (strain K12) # PATRIC 32117662 VBIEscCol129921_1253 # PIR B64867 B64867 # Pfam PF10762 DUF2583 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCHH_ECOLI Uncharacterized protein YchH # RefSeq NP_415723 NC_000913.3 # RefSeq WP_000823885 NZ_LN832404.1 # eggNOG ENOG4105MGX Bacteria # eggNOG ENOG4111VC3 LUCA BLAST swissprot:YCHH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCHH_ECOLI BioCyc ECOL316407:JW1196-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1196-MONOMER BioCyc EcoCyc:EG11533-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11533-MONOMER DOI 10.1016/0378-1119(94)90647-5 http://dx.doi.org/10.1016/0378-1119(94)90647-5 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X61941 http://www.ebi.ac.uk/ena/data/view/X61941 EchoBASE EB1495 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1495 EcoGene EG11533 http://www.ecogene.org/geneInfo.php?eg_id=EG11533 EnsemblBacteria AAC74289 http://www.ensemblgenomes.org/id/AAC74289 EnsemblBacteria AAC74289 http://www.ensemblgenomes.org/id/AAC74289 EnsemblBacteria BAA36063 http://www.ensemblgenomes.org/id/BAA36063 EnsemblBacteria BAA36063 http://www.ensemblgenomes.org/id/BAA36063 EnsemblBacteria BAA36063 http://www.ensemblgenomes.org/id/BAA36063 EnsemblBacteria b1205 http://www.ensemblgenomes.org/id/b1205 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0044011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044011 GO_process GO:0070301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070301 GO_process GO:0071276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071276 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 945762 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945762 HOGENOM HOG000119757 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000119757&db=HOGENOM6 IntAct P0AB49 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AB49* InterPro IPR019698 http://www.ebi.ac.uk/interpro/entry/IPR019698 KEGG_Gene ecj:JW1196 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1196 KEGG_Gene eco:b1205 http://www.genome.jp/dbget-bin/www_bget?eco:b1205 OMA KRCRRDQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KRCRRDQ PSORT swissprot:YCHH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCHH_ECOLI PSORT-B swissprot:YCHH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCHH_ECOLI PSORT2 swissprot:YCHH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCHH_ECOLI Pfam PF10762 http://pfam.xfam.org/family/PF10762 Phobius swissprot:YCHH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCHH_ECOLI ProteinModelPortal P0AB49 http://www.proteinmodelportal.org/query/uniprot/P0AB49 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1833189 http://www.ncbi.nlm.nih.gov/pubmed/1833189 PubMed 7828865 http://www.ncbi.nlm.nih.gov/pubmed/7828865 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415723 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415723 RefSeq WP_000823885 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000823885 STRING 511145.b1205 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1205&targetmode=cogs UniProtKB YCHH_ECOLI http://www.uniprot.org/uniprot/YCHH_ECOLI UniProtKB-AC P0AB49 http://www.uniprot.org/uniprot/P0AB49 charge swissprot:YCHH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCHH_ECOLI eggNOG ENOG4105MGX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105MGX eggNOG ENOG4111VC3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111VC3 epestfind swissprot:YCHH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCHH_ECOLI garnier swissprot:YCHH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCHH_ECOLI helixturnhelix swissprot:YCHH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCHH_ECOLI hmoment swissprot:YCHH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCHH_ECOLI iep swissprot:YCHH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCHH_ECOLI inforesidue swissprot:YCHH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCHH_ECOLI octanol swissprot:YCHH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCHH_ECOLI pepcoil swissprot:YCHH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCHH_ECOLI pepdigest swissprot:YCHH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCHH_ECOLI pepinfo swissprot:YCHH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCHH_ECOLI pepnet swissprot:YCHH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCHH_ECOLI pepstats swissprot:YCHH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCHH_ECOLI pepwheel swissprot:YCHH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCHH_ECOLI pepwindow swissprot:YCHH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCHH_ECOLI sigcleave swissprot:YCHH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCHH_ECOLI ## Database ID URL or Descriptions # AltName DXS_ECOLI 1-deoxyxylulose-5-phosphate synthase # BIOPHYSICOCHEMICAL PROPERTIES pH dependence: Optimum pH is 7.5-8.0.; Temperature dependence Optimum temperature is 42-44 degrees Celsius.; # BRENDA 2.2.1 2026 # BioGrid 4259592 352 # CATALYTIC ACTIVITY DXS_ECOLI Pyruvate + D-glyceraldehyde 3-phosphate = 1- deoxy-D-xylulose 5-phosphate + CO(2). # CDD cd02007 TPP_DXS # COFACTOR DXS_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 17135236}; Note=Binds 1 Mg(2+) ion per subunit. {ECO 0000269|PubMed 17135236}; # COFACTOR DXS_ECOLI Name=thiamine diphosphate; Xref=ChEBI CHEBI 58937; Evidence={ECO 0000269|PubMed 17135236}; Note=Binds 1 thiamine pyrophosphate per subunit. {ECO 0000269|PubMed 17135236}; # EcoGene EG13612 dxs # FUNCTION DXS_ECOLI Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP). {ECO 0000269|PubMed 17135236}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008661 1-deoxy-D-xylulose-5-phosphate synthase activity; IDA:EcoCyc. # GO_function GO:0030976 thiamine pyrophosphate binding; IDA:EcoCyc. # GO_process GO:0006744 ubiquinone biosynthetic process; IDA:EcoCyc. # GO_process GO:0008615 pyridoxine biosynthetic process; IDA:EcoCyc. # GO_process GO:0009228 thiamine biosynthetic process; IMP:EcoCyc. # GO_process GO:0016114 terpenoid biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0019288 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway; IMP:EcoCyc. # GO_process GO:0052865 1-deoxy-D-xylulose 5-phosphate biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.920 -; 1. # Gene3D 3.40.50.970 -; 3. # HAMAP MF_00315 DXP_synth # IntAct P77488 18 # InterPro IPR005474 Transketolase_N # InterPro IPR005475 Transketolase-like_Pyr-bd # InterPro IPR005477 Dxylulose-5-P_synthase # InterPro IPR009014 Transketo_C/PFOR_II # InterPro IPR020826 Transketolase_BS # InterPro IPR029061 THDP-binding # InterPro IPR033247 Transketolase_fam # InterPro IPR033248 Transketolase_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00900 Terpenoid backbone biosynthesis # Organism DXS_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11624 PTHR11624; 2 # PATHWAY Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D- glyceraldehyde 3-phosphate and pyruvate step 1/1. # PATRIC 32115989 VBIEscCol129921_0436 # PDB 2O1S X-ray; 2.40 A; A/B/C/D=1-620 # PIR D64771 D64771 # PROSITE PS00801 TRANSKETOLASE_1 # PROSITE PS00802 TRANSKETOLASE_2 # Pfam PF02779 Transket_pyr # Pfam PF02780 Transketolase_C # Pfam PF13292 DXP_synthase_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DXS_ECOLI 1-deoxy-D-xylulose-5-phosphate synthase # RefSeq NP_414954 NC_000913.3 # RefSeq WP_000006797 NZ_LN832404.1 # SIMILARITY Belongs to the transketolase family. DXPS subfamily. {ECO 0000305}. # SMART SM00861 Transket_pyr # SUBUNIT Homodimer. {ECO:0000269|PubMed 17135236}. # SUPFAM SSF52518 SSF52518; 3 # SUPFAM SSF52922 SSF52922 # TIGRFAMs TIGR00204 dxs # UniPathway UPA00064 UER00091 # eggNOG COG1154 LUCA # eggNOG ENOG4105C2V Bacteria BLAST swissprot:DXS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DXS_ECOLI BioCyc ECOL316407:JW0410-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0410-MONOMER BioCyc EcoCyc:DXS-MONOMER http://biocyc.org/getid?id=EcoCyc:DXS-MONOMER BioCyc MetaCyc:DXS-MONOMER http://biocyc.org/getid?id=MetaCyc:DXS-MONOMER COG COG1154 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1154 DIP DIP-9485N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9485N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.94.24.12857 http://dx.doi.org/10.1073/pnas.94.24.12857 DOI 10.1073/pnas.95.5.2105 http://dx.doi.org/10.1073/pnas.95.5.2105 DOI 10.1074/jbc.M610235200 http://dx.doi.org/10.1074/jbc.M610235200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.4.891-897.2000 http://dx.doi.org/10.1128/JB.182.4.891-897.2000 EC_number EC:2.2.1.7 http://www.genome.jp/dbget-bin/www_bget?EC:2.2.1.7 EMBL AF035440 http://www.ebi.ac.uk/ena/data/view/AF035440 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 ENZYME 2.2.1.7 http://enzyme.expasy.org/EC/2.2.1.7 EchoBASE EB3378 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3378 EcoGene EG13612 http://www.ecogene.org/geneInfo.php?eg_id=EG13612 EnsemblBacteria AAC73523 http://www.ensemblgenomes.org/id/AAC73523 EnsemblBacteria AAC73523 http://www.ensemblgenomes.org/id/AAC73523 EnsemblBacteria BAE76200 http://www.ensemblgenomes.org/id/BAE76200 EnsemblBacteria BAE76200 http://www.ensemblgenomes.org/id/BAE76200 EnsemblBacteria BAE76200 http://www.ensemblgenomes.org/id/BAE76200 EnsemblBacteria b0420 http://www.ensemblgenomes.org/id/b0420 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0008661 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008661 GO_function GO:0030976 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030976 GO_process GO:0006744 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006744 GO_process GO:0008615 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008615 GO_process GO:0009228 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009228 GO_process GO:0016114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016114 GO_process GO:0019288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019288 GO_process GO:0052865 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052865 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.920 http://www.cathdb.info/version/latest/superfamily/3.40.50.920 Gene3D 3.40.50.970 http://www.cathdb.info/version/latest/superfamily/3.40.50.970 GeneID 945060 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945060 HAMAP MF_00315 http://hamap.expasy.org/unirule/MF_00315 HOGENOM HOG000012988 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000012988&db=HOGENOM6 InParanoid P77488 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77488 IntAct P77488 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77488* IntEnz 2.2.1.7 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.2.1.7 InterPro IPR005474 http://www.ebi.ac.uk/interpro/entry/IPR005474 InterPro IPR005475 http://www.ebi.ac.uk/interpro/entry/IPR005475 InterPro IPR005477 http://www.ebi.ac.uk/interpro/entry/IPR005477 InterPro IPR009014 http://www.ebi.ac.uk/interpro/entry/IPR009014 InterPro IPR020826 http://www.ebi.ac.uk/interpro/entry/IPR020826 InterPro IPR029061 http://www.ebi.ac.uk/interpro/entry/IPR029061 InterPro IPR033247 http://www.ebi.ac.uk/interpro/entry/IPR033247 InterPro IPR033248 http://www.ebi.ac.uk/interpro/entry/IPR033248 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0410 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0410 KEGG_Gene eco:b0420 http://www.genome.jp/dbget-bin/www_bget?eco:b0420 KEGG_Orthology KO:K01662 http://www.genome.jp/dbget-bin/www_bget?KO:K01662 KEGG_Pathway ko00900 http://www.genome.jp/kegg-bin/show_pathway?ko00900 KEGG_Reaction rn:R05636 http://www.genome.jp/dbget-bin/www_bget?rn:R05636 MINT MINT-1233858 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1233858 OMA YKGLCGF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YKGLCGF PANTHER PTHR11624 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11624 PDB 2O1S http://www.ebi.ac.uk/pdbe-srv/view/entry/2O1S PDBsum 2O1S http://www.ebi.ac.uk/pdbsum/2O1S PROSITE PS00801 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00801 PROSITE PS00802 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00802 PSORT swissprot:DXS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DXS_ECOLI PSORT-B swissprot:DXS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DXS_ECOLI PSORT2 swissprot:DXS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DXS_ECOLI Pfam PF02779 http://pfam.xfam.org/family/PF02779 Pfam PF02780 http://pfam.xfam.org/family/PF02780 Pfam PF13292 http://pfam.xfam.org/family/PF13292 Phobius swissprot:DXS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DXS_ECOLI PhylomeDB P77488 http://phylomedb.org/?seqid=P77488 ProteinModelPortal P77488 http://www.proteinmodelportal.org/query/uniprot/P77488 PubMed 10648511 http://www.ncbi.nlm.nih.gov/pubmed/10648511 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17135236 http://www.ncbi.nlm.nih.gov/pubmed/17135236 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9371765 http://www.ncbi.nlm.nih.gov/pubmed/9371765 PubMed 9482846 http://www.ncbi.nlm.nih.gov/pubmed/9482846 RefSeq NP_414954 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414954 RefSeq WP_000006797 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000006797 SMART SM00861 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00861 SMR P77488 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77488 STRING 511145.b0420 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0420&targetmode=cogs STRING COG1154 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1154&targetmode=cogs SUPFAM SSF52518 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52518 SUPFAM SSF52922 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52922 TIGRFAMs TIGR00204 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00204 UniProtKB DXS_ECOLI http://www.uniprot.org/uniprot/DXS_ECOLI UniProtKB-AC P77488 http://www.uniprot.org/uniprot/P77488 charge swissprot:DXS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DXS_ECOLI eggNOG COG1154 http://eggnogapi.embl.de/nog_data/html/tree/COG1154 eggNOG ENOG4105C2V http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C2V epestfind swissprot:DXS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DXS_ECOLI garnier swissprot:DXS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DXS_ECOLI helixturnhelix swissprot:DXS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DXS_ECOLI hmoment swissprot:DXS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DXS_ECOLI iep swissprot:DXS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DXS_ECOLI inforesidue swissprot:DXS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DXS_ECOLI octanol swissprot:DXS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DXS_ECOLI pepcoil swissprot:DXS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DXS_ECOLI pepdigest swissprot:DXS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DXS_ECOLI pepinfo swissprot:DXS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DXS_ECOLI pepnet swissprot:DXS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DXS_ECOLI pepstats swissprot:DXS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DXS_ECOLI pepwheel swissprot:DXS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DXS_ECOLI pepwindow swissprot:DXS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DXS_ECOLI sigcleave swissprot:DXS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DXS_ECOLI ## Database ID URL or Descriptions # BioGrid 4261219 422 # CAUTION Was originally thought to be involved in gluconate metabolism and was referred to as GntY. {ECO:0000305|PubMed 9871335}. # COFACTOR Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI 49883; Note=Binds 1 [4Fe-4S] cluster per subunit. The cluster is presumably bound at the interface of two monomers.; # DISRUPTION PHENOTYPE Cells express the stationary phase-specific competition-defective (SPCD) phenotype and are unable to catabolize dsDNA. {ECO:0000269|PubMed 16707682}. # DOMAIN NFUA_ECOLI Consits of two domains, an N-terminal domain that resembles the so-called Fe/S A-type scaffold, and a C-terminal domain that shares sequence identity with Nfu-type scaffold proteins. Both domains are important for NfuA to fulfill its function in vivo. The N-terminal domain does not possess the three conserved cysteine residues thought to act as Fe/S cluster ligands in A-type scaffold proteins, but may keep the ability to interact with apoproteins. {ECO 0000269|PubMed 18339628}. # EcoGene EG12935 nfuA # FUNCTION NFUA_ECOLI Involved in iron-sulfur cluster biogenesis under severe conditions such as iron starvation or oxidative stress. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. Required for E.coli to sustain oxidative stress and iron starvation. Also necessary for the use of extracellular DNA as the sole source of carbon and energy. {ECO 0000269|PubMed 16707682, ECO 0000269|PubMed 18339628}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008198 ferrous iron binding; IBA:GO_Central. # GO_function GO:0051537 2 iron, 2 sulfur cluster binding; IBA:GO_Central. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IDA:EcoCyc. # GO_process GO:0006790 sulfur compound metabolic process; IBA:GO_Central. # GO_process GO:0006979 response to oxidative stress; IMP:EcoCyc. # GO_process GO:0010106 cellular response to iron ion starvation; IMP:EcoCyc. # GO_process GO:0015976 carbon utilization; IMP:EcoCyc. # GO_process GO:0016226 iron-sulfur cluster assembly; IDA:EcoliWiki. # GO_process GO:0097428 protein maturation by iron-sulfur cluster transfer; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0051186 cofactor metabolic process # GOslim_process GO:0051604 protein maturation # Gene3D 2.60.300.12 -; 1. # HAMAP MF_01637 Fe_S_biogen_NfuA # INDUCTION NFUA_ECOLI Up-regulated under conditions of iron depletion or oxidative stress, via IscR. Is also induced by heat shock or the presence of misfolded proteins. {ECO 0000269|PubMed 11917152, ECO 0000269|PubMed 12746439, ECO 0000269|PubMed 18339628}. # IntAct P63020 13 # InterPro IPR000361 FeS_biogenesis # InterPro IPR001075 NIF_FeS_clus_asmbl_NifU_C # InterPro IPR017726 Fe/S_biogenesis_protein_NfuA # Organism NFUA_ECOLI Escherichia coli (strain K12) # PATRIC 32122266 VBIEscCol129921_3510 # PIR A65137 A65137 # Pfam PF01106 NifU # Pfam PF01521 Fe-S_biosyn # ProDom PD002830 NIF_FeS_clus_asmbl_NifU_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NFUA_ECOLI Fe/S biogenesis protein NfuA # RefSeq NP_417873 NC_000913.3 # RefSeq WP_000619389 NZ_LN832404.1 # SIMILARITY Belongs to the NfuA family. {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 18339628}. # SUPFAM SSF89360 SSF89360 # TIGRFAMs TIGR03341 YhgI_GntY # eggNOG COG0316 LUCA # eggNOG COG0694 LUCA # eggNOG ENOG4107RUK Bacteria BLAST swissprot:NFUA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NFUA_ECOLI BioCyc ECOL316407:JW3377-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3377-MONOMER BioCyc EcoCyc:G7748-MONOMER http://biocyc.org/getid?id=EcoCyc:G7748-MONOMER BioCyc MetaCyc:G7748-MONOMER http://biocyc.org/getid?id=MetaCyc:G7748-MONOMER COG COG0316 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0316 COG COG0694 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0694 DIP DIP-48001N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48001N DOI 10.1002/(SICI)1521-4028(199811)38:5/6<395::AID-JOBM395>3.3.CO http://dx.doi.org/10.1002/(SICI)1521-4028(199811)38:5/6<395::AID-JOBM395>3.3.CO DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M303381200 http://dx.doi.org/10.1074/jbc.M303381200 DOI 10.1074/jbc.M709405200 http://dx.doi.org/10.1074/jbc.M709405200 DOI 10.1093/protein/15.2.153 http://dx.doi.org/10.1093/protein/15.2.153 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01974-05 http://dx.doi.org/10.1128/JB.01974-05 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2771 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2771 EcoGene EG12935 http://www.ecogene.org/geneInfo.php?eg_id=EG12935 EnsemblBacteria AAC76439 http://www.ensemblgenomes.org/id/AAC76439 EnsemblBacteria AAC76439 http://www.ensemblgenomes.org/id/AAC76439 EnsemblBacteria BAE77877 http://www.ensemblgenomes.org/id/BAE77877 EnsemblBacteria BAE77877 http://www.ensemblgenomes.org/id/BAE77877 EnsemblBacteria BAE77877 http://www.ensemblgenomes.org/id/BAE77877 EnsemblBacteria b3414 http://www.ensemblgenomes.org/id/b3414 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008198 GO_function GO:0051537 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051537 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GO_process GO:0006979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979 GO_process GO:0010106 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010106 GO_process GO:0015976 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015976 GO_process GO:0016226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016226 GO_process GO:0097428 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097428 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GOslim_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 Gene3D 2.60.300.12 http://www.cathdb.info/version/latest/superfamily/2.60.300.12 GeneID 947925 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947925 HAMAP MF_01637 http://hamap.expasy.org/unirule/MF_01637 HOGENOM HOG000137052 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000137052&db=HOGENOM6 InParanoid P63020 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P63020 IntAct P63020 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P63020* InterPro IPR000361 http://www.ebi.ac.uk/interpro/entry/IPR000361 InterPro IPR001075 http://www.ebi.ac.uk/interpro/entry/IPR001075 InterPro IPR017726 http://www.ebi.ac.uk/interpro/entry/IPR017726 KEGG_Gene ecj:JW3377 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3377 KEGG_Gene eco:b3414 http://www.genome.jp/dbget-bin/www_bget?eco:b3414 KEGG_Orthology KO:K07400 http://www.genome.jp/dbget-bin/www_bget?KO:K07400 OMA ETCLAYC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ETCLAYC PSORT swissprot:NFUA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NFUA_ECOLI PSORT-B swissprot:NFUA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NFUA_ECOLI PSORT2 swissprot:NFUA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NFUA_ECOLI Pfam PF01106 http://pfam.xfam.org/family/PF01106 Pfam PF01521 http://pfam.xfam.org/family/PF01521 Phobius swissprot:NFUA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NFUA_ECOLI PhylomeDB P63020 http://phylomedb.org/?seqid=P63020 ProteinModelPortal P63020 http://www.proteinmodelportal.org/query/uniprot/P63020 PubMed 11917152 http://www.ncbi.nlm.nih.gov/pubmed/11917152 PubMed 12746439 http://www.ncbi.nlm.nih.gov/pubmed/12746439 PubMed 16707682 http://www.ncbi.nlm.nih.gov/pubmed/16707682 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18339628 http://www.ncbi.nlm.nih.gov/pubmed/18339628 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9871335 http://www.ncbi.nlm.nih.gov/pubmed/9871335 RefSeq NP_417873 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417873 RefSeq WP_000619389 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000619389 STRING 511145.b3414 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3414&targetmode=cogs STRING COG0316 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0316&targetmode=cogs STRING COG0694 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0694&targetmode=cogs SUPFAM SSF89360 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF89360 SWISS-2DPAGE P63020 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P63020 TIGRFAMs TIGR03341 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03341 UniProtKB NFUA_ECOLI http://www.uniprot.org/uniprot/NFUA_ECOLI UniProtKB-AC P63020 http://www.uniprot.org/uniprot/P63020 charge swissprot:NFUA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NFUA_ECOLI eggNOG COG0316 http://eggnogapi.embl.de/nog_data/html/tree/COG0316 eggNOG COG0694 http://eggnogapi.embl.de/nog_data/html/tree/COG0694 eggNOG ENOG4107RUK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107RUK epestfind swissprot:NFUA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NFUA_ECOLI garnier swissprot:NFUA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NFUA_ECOLI helixturnhelix swissprot:NFUA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NFUA_ECOLI hmoment swissprot:NFUA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NFUA_ECOLI iep swissprot:NFUA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NFUA_ECOLI inforesidue swissprot:NFUA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NFUA_ECOLI octanol swissprot:NFUA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NFUA_ECOLI pepcoil swissprot:NFUA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NFUA_ECOLI pepdigest swissprot:NFUA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NFUA_ECOLI pepinfo swissprot:NFUA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NFUA_ECOLI pepnet swissprot:NFUA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NFUA_ECOLI pepstats swissprot:NFUA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NFUA_ECOLI pepwheel swissprot:NFUA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NFUA_ECOLI pepwindow swissprot:NFUA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NFUA_ECOLI sigcleave swissprot:NFUA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NFUA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261608 193 # EcoGene EG12807 yrbL # INDUCTION Induced by low extracellular levels of magnesium via the PhoQ/PhoP two-component regulatory system. {ECO:0000269|PubMed 12813061}. # InterPro IPR011009 Kinase-like_dom # InterPro IPR019647 PhoP_reg_network_YrbL # Organism YRBL_ECOLI Escherichia coli (strain K12) # PATRIC 32121834 VBIEscCol129921_3301 # PIR A65112 A65112 # Pfam PF10707 YrbL-PhoP_reg # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YRBL_ECOLI Uncharacterized protein YrbL # RefSeq NP_417674 NC_000913.3 # RefSeq WP_000620405 NZ_LN832404.1 # SUPFAM SSF56112 SSF56112 # eggNOG ENOG4108NIH Bacteria # eggNOG ENOG410ZFFS LUCA BLAST swissprot:YRBL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YRBL_ECOLI BioCyc ECOL316407:JW3174-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3174-MONOMER BioCyc EcoCyc:G7667-MONOMER http://biocyc.org/getid?id=EcoCyc:G7667-MONOMER DIP DIP-48162N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48162N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.185.13.3696-3702.2003 http://dx.doi.org/10.1128/JB.185.13.3696-3702.2003 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2658 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2658 EcoGene EG12807 http://www.ecogene.org/geneInfo.php?eg_id=EG12807 EnsemblBacteria AAC76239 http://www.ensemblgenomes.org/id/AAC76239 EnsemblBacteria AAC76239 http://www.ensemblgenomes.org/id/AAC76239 EnsemblBacteria BAE77251 http://www.ensemblgenomes.org/id/BAE77251 EnsemblBacteria BAE77251 http://www.ensemblgenomes.org/id/BAE77251 EnsemblBacteria BAE77251 http://www.ensemblgenomes.org/id/BAE77251 EnsemblBacteria b3207 http://www.ensemblgenomes.org/id/b3207 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947910 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947910 HOGENOM HOG000125240 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125240&db=HOGENOM6 IntAct P64610 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P64610* InterPro IPR011009 http://www.ebi.ac.uk/interpro/entry/IPR011009 InterPro IPR019647 http://www.ebi.ac.uk/interpro/entry/IPR019647 KEGG_Gene ecj:JW3174 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3174 KEGG_Gene eco:b3207 http://www.genome.jp/dbget-bin/www_bget?eco:b3207 OMA RYLQDWS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RYLQDWS PSORT swissprot:YRBL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YRBL_ECOLI PSORT-B swissprot:YRBL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YRBL_ECOLI PSORT2 swissprot:YRBL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YRBL_ECOLI Pfam PF10707 http://pfam.xfam.org/family/PF10707 Phobius swissprot:YRBL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YRBL_ECOLI ProteinModelPortal P64610 http://www.proteinmodelportal.org/query/uniprot/P64610 PubMed 12813061 http://www.ncbi.nlm.nih.gov/pubmed/12813061 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417674 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417674 RefSeq WP_000620405 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000620405 STRING 511145.b3207 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3207&targetmode=cogs SUPFAM SSF56112 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56112 UniProtKB YRBL_ECOLI http://www.uniprot.org/uniprot/YRBL_ECOLI UniProtKB-AC P64610 http://www.uniprot.org/uniprot/P64610 charge swissprot:YRBL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YRBL_ECOLI eggNOG ENOG4108NIH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108NIH eggNOG ENOG410ZFFS http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZFFS epestfind swissprot:YRBL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YRBL_ECOLI garnier swissprot:YRBL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YRBL_ECOLI helixturnhelix swissprot:YRBL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YRBL_ECOLI hmoment swissprot:YRBL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YRBL_ECOLI iep swissprot:YRBL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YRBL_ECOLI inforesidue swissprot:YRBL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YRBL_ECOLI octanol swissprot:YRBL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YRBL_ECOLI pepcoil swissprot:YRBL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YRBL_ECOLI pepdigest swissprot:YRBL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YRBL_ECOLI pepinfo swissprot:YRBL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YRBL_ECOLI pepnet swissprot:YRBL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YRBL_ECOLI pepstats swissprot:YRBL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YRBL_ECOLI pepwheel swissprot:YRBL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YRBL_ECOLI pepwindow swissprot:YRBL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YRBL_ECOLI sigcleave swissprot:YRBL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YRBL_ECOLI ## Database ID URL or Descriptions # AltName Chitin disaccharide deacetylase {ECO:0000303|PubMed 22797760} # AltName Chitobiose deacetylase {ECO:0000303|PubMed 22797760} # AltName Chitobiose-6P deacetylase {ECO:0000303|PubMed 22797760} # AltName Chitotriose deacetylase {ECO:0000303|PubMed 22797760} # AltName Chitotriose-6P deacetylase {ECO:0000303|PubMed 22797760} # BioGrid 4260305 16 # CATALYTIC ACTIVITY Diacetylchitobiose-6-phosphate + H(2)O = N- monoacetylchitobiose-6-phosphate + acetate. {ECO:0000269|PubMed 22797760}. # CATALYTIC ACTIVITY N,N'-diacetylchitobiose + H(2)O = N-acetyl- beta-D-glucosaminyl-(1->4)-D-glucosamine + acetate. {ECO:0000269|PubMed 22797760}. # CAUTION Was originally (PubMed:8121401 and PubMed 2179047) characterized as part of a cryptic cel operon for a cellobiose degradation system. The Cel+ phenotype is due to mutations making expression chitobiose-independent and altering the substrate specificity. {ECO:0000305}. # CDD cd10803 YdjC_EF3048_like # COFACTOR CHBG_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250|UniProtKB Q53WD3}; # DISRUPTION PHENOTYPE Cells lacking this gene are unable to grow on chitobiose and chitotriose. {ECO:0000269|PubMed 22797760}. # EcoGene EG12198 chbG # FUNCTION CHBG_ECOLI ChbG is essential for growth on the acetylated chitooligosaccharides chitobiose and chitotriose but is dispensable for growth on cellobiose and chitosan dimer, the deacetylated form of chitobiose. Deacetylation of chitobiose-6-P and chitotriose-6-P is necessary for both the activation of the chb promoter by the regulatory protein ChbR and the hydrolysis of phosphorylated beta-glucosides by the phospho-beta-glucosidase ChbF. Catalyzes the removal of only one acetyl group from chitobiose-6-P to yield monoacetylchitobiose-6-P, the inducer of ChbR and the substrate of ChbF. It can also use chitobiose and chitotriose as substrates. {ECO 0000269|PubMed 22797760}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0019213 deacetylase activity; IDA:EcoCyc. # GO_function GO:0036311 chitin disaccharide deacetylase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0000272 polysaccharide catabolic process; IEA:UniProtKB-HAMAP. # GO_process GO:0006032 chitin catabolic process; IEA:UniProtKB-UniPathway. # GO_process GO:0052777 diacetylchitobiose catabolic process; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # Gene3D 3.20.20.370 -; 1. # HAMAP MF_01246 COD # INDUCTION By N,N'-diacetylchitobiose. {ECO:0000269|PubMed 9405618}. # IntAct P37794 4 # InterPro IPR002509 NODB_dom # InterPro IPR006879 YdjC-like # InterPro IPR011330 Glyco_hydro/deAcase_b/a-brl # InterPro IPR022948 COD_ChbG_bac # Organism CHBG_ECOLI Escherichia coli (strain K12) # PATHWAY Glycan degradation; chitin degradation. {ECO:0000305|PubMed 9405618}. # PATRIC 32118775 VBIEscCol129921_1805 # PIR E64932 E64932 # Pfam PF04794 YdjC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Chitooligosaccharide deacetylase ChbG {ECO:0000303|PubMed 22797760} # RefSeq NP_416247 NC_000913.3 # RefSeq WP_000440471 NZ_LN832404.1 # SIMILARITY Belongs to the YdjC deacetylase family. ChbG subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION CHBG_ECOLI Cytoplasm {ECO 0000269|PubMed 22797760}. # SUBUNIT Homodimer. {ECO:0000255|HAMAP-Rule MF_01246}. # SUPFAM SSF88713 SSF88713 # eggNOG COG3394 LUCA # eggNOG ENOG410901P Bacteria BLAST swissprot:CHBG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CHBG_ECOLI BioCyc ECOL316407:JW1722-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1722-MONOMER BioCyc EcoCyc:EG12198-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12198-MONOMER BioCyc MetaCyc:EG12198-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12198-MONOMER COG COG3394 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3394 DOI 10.1007/BF00281796 http://dx.doi.org/10.1007/BF00281796 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.94.26.14367 http://dx.doi.org/10.1073/pnas.94.26.14367 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00533-12 http://dx.doi.org/10.1128/JB.00533-12 EC_number EC:3.5.1.105 {ECO:0000269|PubMed:22797760} http://www.genome.jp/dbget-bin/www_bget?EC:3.5.1.105 {ECO:0000269|PubMed:22797760} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M55161 http://www.ebi.ac.uk/ena/data/view/M55161 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X52890 http://www.ebi.ac.uk/ena/data/view/X52890 EMBL X66725 http://www.ebi.ac.uk/ena/data/view/X66725 EMBL X66725 http://www.ebi.ac.uk/ena/data/view/X66725 ENZYME 3.5.1.105 {ECO:0000269|PubMed:22797760} http://enzyme.expasy.org/EC/3.5.1.105 {ECO:0000269|PubMed:22797760} EchoBASE EB2115 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2115 EcoGene EG12198 http://www.ecogene.org/geneInfo.php?eg_id=EG12198 EnsemblBacteria AAC74803 http://www.ensemblgenomes.org/id/AAC74803 EnsemblBacteria AAC74803 http://www.ensemblgenomes.org/id/AAC74803 EnsemblBacteria BAA15514 http://www.ensemblgenomes.org/id/BAA15514 EnsemblBacteria BAA15514 http://www.ensemblgenomes.org/id/BAA15514 EnsemblBacteria BAA15514 http://www.ensemblgenomes.org/id/BAA15514 EnsemblBacteria b1733 http://www.ensemblgenomes.org/id/b1733 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0019213 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019213 GO_function GO:0036311 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036311 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0000272 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000272 GO_process GO:0006032 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006032 GO_process GO:0052777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052777 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 3.20.20.370 http://www.cathdb.info/version/latest/superfamily/3.20.20.370 GeneID 946231 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946231 HAMAP MF_01246 http://hamap.expasy.org/unirule/MF_01246 HOGENOM HOG000225034 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000225034&db=HOGENOM6 InParanoid P37794 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37794 IntAct P37794 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37794* IntEnz 3.5.1.105 {ECO:0000269|PubMed:22797760} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.1.105 {ECO:0000269|PubMed:22797760} InterPro IPR002509 http://www.ebi.ac.uk/interpro/entry/IPR002509 InterPro IPR006879 http://www.ebi.ac.uk/interpro/entry/IPR006879 InterPro IPR011330 http://www.ebi.ac.uk/interpro/entry/IPR011330 InterPro IPR022948 http://www.ebi.ac.uk/interpro/entry/IPR022948 KEGG_Gene ecj:JW1722 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1722 KEGG_Gene eco:b1733 http://www.genome.jp/dbget-bin/www_bget?eco:b1733 KEGG_Orthology KO:K03478 http://www.genome.jp/dbget-bin/www_bget?KO:K03478 OMA EPTHIDS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EPTHIDS PSORT swissprot:CHBG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CHBG_ECOLI PSORT-B swissprot:CHBG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CHBG_ECOLI PSORT2 swissprot:CHBG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CHBG_ECOLI Pfam PF04794 http://pfam.xfam.org/family/PF04794 Phobius swissprot:CHBG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CHBG_ECOLI PhylomeDB P37794 http://phylomedb.org/?seqid=P37794 ProteinModelPortal P37794 http://www.proteinmodelportal.org/query/uniprot/P37794 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1987146 http://www.ncbi.nlm.nih.gov/pubmed/1987146 PubMed 2179047 http://www.ncbi.nlm.nih.gov/pubmed/2179047 PubMed 22797760 http://www.ncbi.nlm.nih.gov/pubmed/22797760 PubMed 8121401 http://www.ncbi.nlm.nih.gov/pubmed/8121401 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9405618 http://www.ncbi.nlm.nih.gov/pubmed/9405618 RefSeq NP_416247 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416247 RefSeq WP_000440471 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000440471 SMR P37794 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37794 STRING 511145.b1733 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1733&targetmode=cogs STRING COG3394 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3394&targetmode=cogs SUPFAM SSF88713 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF88713 UniProtKB CHBG_ECOLI http://www.uniprot.org/uniprot/CHBG_ECOLI UniProtKB-AC P37794 http://www.uniprot.org/uniprot/P37794 charge swissprot:CHBG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CHBG_ECOLI eggNOG COG3394 http://eggnogapi.embl.de/nog_data/html/tree/COG3394 eggNOG ENOG410901P http://eggnogapi.embl.de/nog_data/html/tree/ENOG410901P epestfind swissprot:CHBG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CHBG_ECOLI garnier swissprot:CHBG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CHBG_ECOLI helixturnhelix swissprot:CHBG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CHBG_ECOLI hmoment swissprot:CHBG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CHBG_ECOLI iep swissprot:CHBG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CHBG_ECOLI inforesidue swissprot:CHBG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CHBG_ECOLI octanol swissprot:CHBG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CHBG_ECOLI pepcoil swissprot:CHBG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CHBG_ECOLI pepdigest swissprot:CHBG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CHBG_ECOLI pepinfo swissprot:CHBG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CHBG_ECOLI pepnet swissprot:CHBG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CHBG_ECOLI pepstats swissprot:CHBG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CHBG_ECOLI pepwheel swissprot:CHBG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CHBG_ECOLI pepwindow swissprot:CHBG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CHBG_ECOLI sigcleave swissprot:CHBG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CHBG_ECOLI ## Database ID URL or Descriptions # AltName HYCD_ECOLI Hydrogenase 3 component D # BioGrid 4261429 6 # EcoGene EG10477 hycD # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0016491 oxidoreductase activity; IEA:UniProtKB-KW. # GO_process GO:0055114 oxidation-reduction process; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0008150 biological_process # InterPro IPR001694 NADH_UbQ_OxRdtase_su1/FPO # InterPro IPR018086 NADH_UbQ_OxRdtase_su1_CS # Organism HYCD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11432 PTHR11432 # PATRIC 32120844 VBIEscCol129921_2814 # PIR S08622 S08622 # PROSITE PS00667 COMPLEX1_ND1_1 # PROSITE PS00668 COMPLEX1_ND1_2 # Pfam PF00146 NADHdh # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HYCD_ECOLI Formate hydrogenlyase subunit 4 # RefSeq NP_417202 NC_000913.3 # RefSeq WP_000115224 NZ_LN832404.1 # SIMILARITY Belongs to the complex I subunit 1 family. {ECO 0000305}. # SUBCELLULAR LOCATION HYCD_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT HYCD_ECOLI FHL comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (isoenzyme 3). In this non- energy conserving pathway molecular hydrogen and carbodioxide from formate are released. # TCDB 3.D.1.9 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family # eggNOG COG0650 LUCA # eggNOG ENOG4107TDF Bacteria BLAST swissprot:HYCD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HYCD_ECOLI BioCyc ECOL316407:JW2692-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2692-MONOMER BioCyc EcoCyc:HYCD-MONOMER http://biocyc.org/getid?id=EcoCyc:HYCD-MONOMER BioCyc MetaCyc:HYCD-MONOMER http://biocyc.org/getid?id=MetaCyc:HYCD-MONOMER COG COG0650 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0650 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1990.tb00590.x http://dx.doi.org/10.1111/j.1365-2958.1990.tb00590.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EMBL X17506 http://www.ebi.ac.uk/ena/data/view/X17506 EchoBASE EB0472 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0472 EcoGene EG10477 http://www.ecogene.org/geneInfo.php?eg_id=EG10477 EnsemblBacteria AAC75764 http://www.ensemblgenomes.org/id/AAC75764 EnsemblBacteria AAC75764 http://www.ensemblgenomes.org/id/AAC75764 EnsemblBacteria BAE76799 http://www.ensemblgenomes.org/id/BAE76799 EnsemblBacteria BAE76799 http://www.ensemblgenomes.org/id/BAE76799 EnsemblBacteria BAE76799 http://www.ensemblgenomes.org/id/BAE76799 EnsemblBacteria b2722 http://www.ensemblgenomes.org/id/b2722 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_process GO:0055114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 948994 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948994 HOGENOM HOG000228277 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000228277&db=HOGENOM6 InParanoid P16430 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P16430 IntAct P16430 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P16430* InterPro IPR001694 http://www.ebi.ac.uk/interpro/entry/IPR001694 InterPro IPR018086 http://www.ebi.ac.uk/interpro/entry/IPR018086 KEGG_Gene ecj:JW2692 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2692 KEGG_Gene eco:b2722 http://www.genome.jp/dbget-bin/www_bget?eco:b2722 KEGG_Orthology KO:K15829 http://www.genome.jp/dbget-bin/www_bget?KO:K15829 OMA VYHWPVA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VYHWPVA PANTHER PTHR11432 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11432 PROSITE PS00667 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00667 PROSITE PS00668 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00668 PSORT swissprot:HYCD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HYCD_ECOLI PSORT-B swissprot:HYCD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HYCD_ECOLI PSORT2 swissprot:HYCD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HYCD_ECOLI Pfam PF00146 http://pfam.xfam.org/family/PF00146 Phobius swissprot:HYCD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HYCD_ECOLI PhylomeDB P16430 http://phylomedb.org/?seqid=P16430 ProteinModelPortal P16430 http://www.proteinmodelportal.org/query/uniprot/P16430 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2187144 http://www.ncbi.nlm.nih.gov/pubmed/2187144 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417202 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417202 RefSeq WP_000115224 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000115224 STRING 511145.b2722 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2722&targetmode=cogs STRING COG0650 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0650&targetmode=cogs TCDB 3.D.1.9 http://www.tcdb.org/search/result.php?tc=3.D.1.9 UniProtKB HYCD_ECOLI http://www.uniprot.org/uniprot/HYCD_ECOLI UniProtKB-AC P16430 http://www.uniprot.org/uniprot/P16430 charge swissprot:HYCD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HYCD_ECOLI eggNOG COG0650 http://eggnogapi.embl.de/nog_data/html/tree/COG0650 eggNOG ENOG4107TDF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107TDF epestfind swissprot:HYCD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HYCD_ECOLI garnier swissprot:HYCD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HYCD_ECOLI helixturnhelix swissprot:HYCD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HYCD_ECOLI hmoment swissprot:HYCD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HYCD_ECOLI iep swissprot:HYCD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HYCD_ECOLI inforesidue swissprot:HYCD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HYCD_ECOLI octanol swissprot:HYCD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HYCD_ECOLI pepcoil swissprot:HYCD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HYCD_ECOLI pepdigest swissprot:HYCD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HYCD_ECOLI pepinfo swissprot:HYCD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HYCD_ECOLI pepnet swissprot:HYCD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HYCD_ECOLI pepstats swissprot:HYCD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HYCD_ECOLI pepwheel swissprot:HYCD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HYCD_ECOLI pepwindow swissprot:HYCD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HYCD_ECOLI sigcleave swissprot:HYCD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HYCD_ECOLI ## Database ID URL or Descriptions # BioGrid 4262219 7 # EcoGene EG12068 napF # FUNCTION NAPF_ECOLI Involved in electron transfer. # GO_component GO:0005737 cytoplasm; IDA:EcoCyc. # GO_function GO:0005506 iron ion binding; IEA:InterPro. # GO_function GO:0009055 electron carrier activity; IEA:InterPro. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0006979 response to oxidative stress; IMP:EcoCyc. # GO_process GO:0055114 oxidation-reduction process; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # InterPro IPR004496 NapF # InterPro IPR017896 4Fe4S_Fe-S-bd # InterPro IPR017900 4Fe4S_Fe_S_CS # Organism NAPF_ECOLI Escherichia coli (strain K12) # PATRIC 32119775 VBIEscCol129921_2297 # PIR F64990 F64990 # PROSITE PS00198 4FE4S_FER_1; 3 # PROSITE PS51379 4FE4S_FER_2; 3 # Pfam PF00037 Fer4 # Pfam PF12800 Fer4_4 # Pfam PF13187 Fer4_9 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NAPF_ECOLI Ferredoxin-type protein NapF # RefSeq NP_416712 NC_000913.3 # RefSeq WP_000686723 NZ_LN832404.1 # SIMILARITY Contains 3 4Fe-4S ferredoxin-type domains. {ECO:0000255|PROSITE-ProRule PRU00711}. # TIGRFAMs TIGR00402 napF # eggNOG COG1145 LUCA # eggNOG ENOG4108ZNS Bacteria BLAST swissprot:NAPF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NAPF_ECOLI BioCyc ECOL316407:JW2196-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2196-MONOMER BioCyc EcoCyc:NAPF-MONOMER http://biocyc.org/getid?id=EcoCyc:NAPF-MONOMER COG COG1145 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1145 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00008 http://www.ebi.ac.uk/ena/data/view/U00008 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1995 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1995 EcoGene EG12068 http://www.ecogene.org/geneInfo.php?eg_id=EG12068 EnsemblBacteria AAC75268 http://www.ensemblgenomes.org/id/AAC75268 EnsemblBacteria AAC75268 http://www.ensemblgenomes.org/id/AAC75268 EnsemblBacteria BAA15991 http://www.ensemblgenomes.org/id/BAA15991 EnsemblBacteria BAA15991 http://www.ensemblgenomes.org/id/BAA15991 EnsemblBacteria BAA15991 http://www.ensemblgenomes.org/id/BAA15991 EnsemblBacteria b2208 http://www.ensemblgenomes.org/id/b2208 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0006979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979 GO_process GO:0055114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 946813 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946813 HOGENOM HOG000275477 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275477&db=HOGENOM6 InParanoid P0AAL0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAL0 InterPro IPR004496 http://www.ebi.ac.uk/interpro/entry/IPR004496 InterPro IPR017896 http://www.ebi.ac.uk/interpro/entry/IPR017896 InterPro IPR017900 http://www.ebi.ac.uk/interpro/entry/IPR017900 KEGG_Gene ecj:JW2196 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2196 KEGG_Gene eco:b2208 http://www.genome.jp/dbget-bin/www_bget?eco:b2208 KEGG_Orthology KO:K02572 http://www.genome.jp/dbget-bin/www_bget?KO:K02572 OMA FSCKDPC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FSCKDPC PROSITE PS00198 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00198 PROSITE PS51379 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51379 PSORT swissprot:NAPF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NAPF_ECOLI PSORT-B swissprot:NAPF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NAPF_ECOLI PSORT2 swissprot:NAPF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NAPF_ECOLI Pfam PF00037 http://pfam.xfam.org/family/PF00037 Pfam PF12800 http://pfam.xfam.org/family/PF12800 Pfam PF13187 http://pfam.xfam.org/family/PF13187 Phobius swissprot:NAPF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NAPF_ECOLI PhylomeDB P0AAL0 http://phylomedb.org/?seqid=P0AAL0 ProteinModelPortal P0AAL0 http://www.proteinmodelportal.org/query/uniprot/P0AAL0 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416712 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416712 RefSeq WP_000686723 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000686723 STRING 511145.b2208 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2208&targetmode=cogs STRING COG1145 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1145&targetmode=cogs TIGRFAMs TIGR00402 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00402 UniProtKB NAPF_ECOLI http://www.uniprot.org/uniprot/NAPF_ECOLI UniProtKB-AC P0AAL0 http://www.uniprot.org/uniprot/P0AAL0 charge swissprot:NAPF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NAPF_ECOLI eggNOG COG1145 http://eggnogapi.embl.de/nog_data/html/tree/COG1145 eggNOG ENOG4108ZNS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZNS epestfind swissprot:NAPF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NAPF_ECOLI garnier swissprot:NAPF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NAPF_ECOLI helixturnhelix swissprot:NAPF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NAPF_ECOLI hmoment swissprot:NAPF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NAPF_ECOLI iep swissprot:NAPF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NAPF_ECOLI inforesidue swissprot:NAPF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NAPF_ECOLI octanol swissprot:NAPF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NAPF_ECOLI pepcoil swissprot:NAPF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NAPF_ECOLI pepdigest swissprot:NAPF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NAPF_ECOLI pepinfo swissprot:NAPF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NAPF_ECOLI pepnet swissprot:NAPF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NAPF_ECOLI pepstats swissprot:NAPF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NAPF_ECOLI pepwheel swissprot:NAPF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NAPF_ECOLI pepwindow swissprot:NAPF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NAPF_ECOLI sigcleave swissprot:NAPF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NAPF_ECOLI ## Database ID URL or Descriptions # BioGrid 4261160 4 # CAZy GH25 Glycoside Hydrolase Family 25 # EcoGene EG14067 yegX # GO_function GO:0003796 lysozyme activity; IEA:InterPro. # GO_process GO:0005975 carbohydrate metabolic process; IEA:InterPro. # GO_process GO:0009253 peptidoglycan catabolic process; IEA:InterPro. # GO_process GO:0016998 cell wall macromolecule catabolic process; IEA:InterPro. # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # Gene3D 3.20.20.80 -; 1. # InterPro IPR002053 Glyco_hydro_25 # InterPro IPR008270 Glyco_hydro_25_AS # InterPro IPR013781 Glyco_hydro_catalytic_dom # InterPro IPR017853 Glycoside_hydrolase_SF # InterPro IPR018077 Glyco_hydro_fam25_subgr # Organism YEGX_ECOLI Escherichia coli (strain K12) # PATRIC 32119537 VBIEscCol129921_2179 # PIR E64977 E64977 # PROSITE PS00953 GLYCOSYL_HYDROL_F25 # Pfam PF01183 Glyco_hydro_25 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEGX_ECOLI Uncharacterized protein YegX # RefSeq NP_416605 NC_000913.3 # RefSeq WP_001351783 NZ_LN832404.1 # SIMILARITY Belongs to the glycosyl hydrolase 25 family. {ECO 0000305}. # SMART SM00641 Glyco_25 # SUPFAM SSF51445 SSF51445 # eggNOG COG3757 LUCA # eggNOG ENOG4108UQ1 Bacteria BLAST swissprot:YEGX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEGX_ECOLI BioCyc ECOL316407:JW5345-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5345-MONOMER BioCyc EcoCyc:G7134-MONOMER http://biocyc.org/getid?id=EcoCyc:G7134-MONOMER COG COG3757 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3757 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3820 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3820 EcoGene EG14067 http://www.ecogene.org/geneInfo.php?eg_id=EG14067 EnsemblBacteria AAC75163 http://www.ensemblgenomes.org/id/AAC75163 EnsemblBacteria AAC75163 http://www.ensemblgenomes.org/id/AAC75163 EnsemblBacteria BAA15970 http://www.ensemblgenomes.org/id/BAA15970 EnsemblBacteria BAA15970 http://www.ensemblgenomes.org/id/BAA15970 EnsemblBacteria BAA15970 http://www.ensemblgenomes.org/id/BAA15970 EnsemblBacteria b2102 http://www.ensemblgenomes.org/id/b2102 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003796 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003796 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GO_process GO:0009253 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009253 GO_process GO:0016998 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016998 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 3.20.20.80 http://www.cathdb.info/version/latest/superfamily/3.20.20.80 GeneID 945543 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945543 HOGENOM HOG000094644 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000094644&db=HOGENOM6 InParanoid P76421 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76421 InterPro IPR002053 http://www.ebi.ac.uk/interpro/entry/IPR002053 InterPro IPR008270 http://www.ebi.ac.uk/interpro/entry/IPR008270 InterPro IPR013781 http://www.ebi.ac.uk/interpro/entry/IPR013781 InterPro IPR017853 http://www.ebi.ac.uk/interpro/entry/IPR017853 InterPro IPR018077 http://www.ebi.ac.uk/interpro/entry/IPR018077 KEGG_Gene ecj:JW5345 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5345 KEGG_Gene eco:b2102 http://www.genome.jp/dbget-bin/www_bget?eco:b2102 KEGG_Orthology KO:K07273 http://www.genome.jp/dbget-bin/www_bget?KO:K07273 OMA DVSNHQG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DVSNHQG PROSITE PS00953 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00953 PSORT swissprot:YEGX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEGX_ECOLI PSORT-B swissprot:YEGX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEGX_ECOLI PSORT2 swissprot:YEGX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEGX_ECOLI Pfam PF01183 http://pfam.xfam.org/family/PF01183 Phobius swissprot:YEGX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEGX_ECOLI PhylomeDB P76421 http://phylomedb.org/?seqid=P76421 ProteinModelPortal P76421 http://www.proteinmodelportal.org/query/uniprot/P76421 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416605 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416605 RefSeq WP_001351783 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001351783 SMART SM00641 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00641 SMR P76421 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76421 STRING 511145.b2102 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2102&targetmode=cogs STRING COG3757 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3757&targetmode=cogs SUPFAM SSF51445 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51445 UniProtKB YEGX_ECOLI http://www.uniprot.org/uniprot/YEGX_ECOLI UniProtKB-AC P76421 http://www.uniprot.org/uniprot/P76421 charge swissprot:YEGX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEGX_ECOLI eggNOG COG3757 http://eggnogapi.embl.de/nog_data/html/tree/COG3757 eggNOG ENOG4108UQ1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UQ1 epestfind swissprot:YEGX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEGX_ECOLI garnier swissprot:YEGX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEGX_ECOLI helixturnhelix swissprot:YEGX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEGX_ECOLI hmoment swissprot:YEGX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEGX_ECOLI iep swissprot:YEGX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEGX_ECOLI inforesidue swissprot:YEGX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEGX_ECOLI octanol swissprot:YEGX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEGX_ECOLI pepcoil swissprot:YEGX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEGX_ECOLI pepdigest swissprot:YEGX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEGX_ECOLI pepinfo swissprot:YEGX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEGX_ECOLI pepnet swissprot:YEGX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEGX_ECOLI pepstats swissprot:YEGX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEGX_ECOLI pepwheel swissprot:YEGX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEGX_ECOLI pepwindow swissprot:YEGX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEGX_ECOLI sigcleave swissprot:YEGX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEGX_ECOLI ## Database ID URL or Descriptions # BioGrid 4262588 6 # EcoGene EG11707 yidL # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0000987 core promoter proximal region sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IBA:GO_Central. # GO_process GO:0006351 transcription, DNA-templated; ISS:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IBA:GO_Central. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; ISS:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.60 -; 2. # Gene3D 2.60.120.280 -; 1. # IntAct P31449 10 # InterPro IPR003313 AraC-bd # InterPro IPR009057 Homeodomain-like # InterPro IPR018060 HTH_AraC # InterPro IPR018062 HTH_AraC-typ_CS # Organism YIDL_ECOLI Escherichia coli (strain K12) # PATRIC 32122851 VBIEscCol129921_3801 # PIR A65170 A65170 # PROSITE PS00041 HTH_ARAC_FAMILY_1 # PROSITE PS01124 HTH_ARAC_FAMILY_2 # Pfam PF02311 AraC_binding # Pfam PF12833 HTH_18 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIDL_ECOLI Uncharacterized HTH-type transcriptional regulator YidL # RefSeq NP_418136 NC_000913.3 # RefSeq WP_001013540 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA62032.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAE77613.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Contains 1 HTH araC/xylS-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00593}. # SMART SM00342 HTH_ARAC # SUPFAM SSF46689 SSF46689; 2 # SUPFAM SSF51215 SSF51215 # eggNOG ENOG4108AHD Bacteria # eggNOG ENOG410ZPV3 LUCA BLAST swissprot:YIDL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIDL_ECOLI BioCyc ECOL316407:JW3656-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3656-MONOMER BioCyc EcoCyc:EG11707-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11707-MONOMER DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1658 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1658 EcoGene EG11707 http://www.ecogene.org/geneInfo.php?eg_id=EG11707 EnsemblBacteria AAC76703 http://www.ensemblgenomes.org/id/AAC76703 EnsemblBacteria AAC76703 http://www.ensemblgenomes.org/id/AAC76703 EnsemblBacteria BAE77613 http://www.ensemblgenomes.org/id/BAE77613 EnsemblBacteria BAE77613 http://www.ensemblgenomes.org/id/BAE77613 EnsemblBacteria BAE77613 http://www.ensemblgenomes.org/id/BAE77613 EnsemblBacteria b3680 http://www.ensemblgenomes.org/id/b3680 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000987 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000987 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 Gene3D 2.60.120.280 http://www.cathdb.info/version/latest/superfamily/2.60.120.280 GeneID 948186 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948186 HOGENOM HOG000126327 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126327&db=HOGENOM6 InParanoid P31449 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31449 IntAct P31449 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31449* InterPro IPR003313 http://www.ebi.ac.uk/interpro/entry/IPR003313 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR018060 http://www.ebi.ac.uk/interpro/entry/IPR018060 InterPro IPR018062 http://www.ebi.ac.uk/interpro/entry/IPR018062 KEGG_Gene ecj:JW3656 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3656 KEGG_Gene eco:b3680 http://www.genome.jp/dbget-bin/www_bget?eco:b3680 PROSITE PS00041 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00041 PROSITE PS01124 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01124 PSORT swissprot:YIDL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIDL_ECOLI PSORT-B swissprot:YIDL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIDL_ECOLI PSORT2 swissprot:YIDL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIDL_ECOLI Pfam PF02311 http://pfam.xfam.org/family/PF02311 Pfam PF12833 http://pfam.xfam.org/family/PF12833 Phobius swissprot:YIDL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIDL_ECOLI ProteinModelPortal P31449 http://www.proteinmodelportal.org/query/uniprot/P31449 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418136 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418136 RefSeq WP_001013540 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001013540 SMART SM00342 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00342 SMR P31449 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31449 STRING 511145.b3680 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3680&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF51215 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51215 UniProtKB YIDL_ECOLI http://www.uniprot.org/uniprot/YIDL_ECOLI UniProtKB-AC P31449 http://www.uniprot.org/uniprot/P31449 charge swissprot:YIDL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIDL_ECOLI eggNOG ENOG4108AHD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108AHD eggNOG ENOG410ZPV3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZPV3 epestfind swissprot:YIDL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIDL_ECOLI garnier swissprot:YIDL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIDL_ECOLI helixturnhelix swissprot:YIDL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIDL_ECOLI hmoment swissprot:YIDL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIDL_ECOLI iep swissprot:YIDL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIDL_ECOLI inforesidue swissprot:YIDL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIDL_ECOLI octanol swissprot:YIDL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIDL_ECOLI pepcoil swissprot:YIDL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIDL_ECOLI pepdigest swissprot:YIDL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIDL_ECOLI pepinfo swissprot:YIDL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIDL_ECOLI pepnet swissprot:YIDL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIDL_ECOLI pepstats swissprot:YIDL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIDL_ECOLI pepwheel swissprot:YIDL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIDL_ECOLI pepwindow swissprot:YIDL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIDL_ECOLI sigcleave swissprot:YIDL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIDL_ECOLI ## Database ID URL or Descriptions # AltName HSLU_ECOLI Heat shock protein HslU # AltName HSLU_ECOLI Unfoldase HslU # BIOPHYSICOCHEMICAL PROPERTIES HSLU_ECOLI Kinetic parameters KM=0.31 mM for ATP (in the absence of HslV) {ECO 0000269|PubMed 15696175, ECO 0000269|PubMed 8662828}; KM=0.28 mM for ATP (in the presence of HslV) {ECO 0000269|PubMed 15696175, ECO 0000269|PubMed 8662828}; KM=5.2 uM for Arc-MYL-st11 (at 37 degrees Celsius) {ECO 0000269|PubMed 15696175, ECO 0000269|PubMed 8662828}; Vmax=57 pmol/min/mg enzyme (in the absence of HslV) {ECO 0000269|PubMed 15696175, ECO 0000269|PubMed 8662828}; Vmax=213 pmol/min/mg enzyme (in the presence of HslV) {ECO 0000269|PubMed 15696175, ECO 0000269|PubMed 8662828}; Note=Arc is a repressor protein, Arc-MYL-st11 is a hyperstable variant of Arc.; Temperature dependence Optimum temperature is 55 degrees Celsius. {ECO 0000269|PubMed 15696175, ECO 0000269|PubMed 8662828}; # BioGrid 4261787 209 # EcoGene EG11881 hslU # FUNCTION HSLU_ECOLI ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. {ECO 0000269|PubMed 10419524, ECO 0000269|PubMed 10452560, ECO 0000269|PubMed 15696175, ECO 0000269|PubMed 8650174, ECO 0000269|PubMed 8662828, ECO 0000269|PubMed 9288941, ECO 0000269|PubMed 9393683}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0009376 HslUV protease complex; IEA:UniProtKB-HAMAP. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0016887 ATPase activity; IDA:EcoCyc. # GO_function GO:0070011 peptidase activity, acting on L-amino acid peptides; IEA:InterPro. # GO_process GO:0009408 response to heat; IEP:EcoliWiki. # GO_process GO:0043335 protein unfolding; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_component GO:0043234 protein complex # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.300 -; 2. # HAMAP MF_00249 HslU # INDUCTION By heat shock. {ECO:0000269|PubMed 8244018}. # INTERACTION HSLU_ECOLI Self; NbExp=2; IntAct=EBI-369317, EBI-369317; P0A7B8 hslV; NbExp=6; IntAct=EBI-369317, EBI-552265; P0AFZ5 sulA; NbExp=5; IntAct=EBI-369317, EBI-2012039; # IntAct P0A6H5 46 # InterPro IPR003593 AAA+_ATPase # InterPro IPR003959 ATPase_AAA_core # InterPro IPR004491 HslU # InterPro IPR019489 Clp_ATPase_C # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko03110 Chaperones and folding catalysts # Organism HSLU_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11262:SF3 PTHR11262:SF3; 2 # PATRIC 32123377 VBIEscCol129921_4049 # PDB 1DO0 X-ray; 3.00 A; A/B/C/D/E/F=2-443 # PDB 1DO2 X-ray; 4.00 A; A/B/C/D=2-443 # PDB 1E94 X-ray; 2.80 A; E/F=2-443 # PDB 1G4A X-ray; 3.00 A; E/F=1-443 # PDB 1G4B X-ray; 7.00 A; E/F/K/L=1-443 # PDB 1HQY X-ray; 2.80 A; E/F=2-443 # PDB 1HT1 X-ray; 2.80 A; E/F/G/I=2-443 # PDB 1HT2 X-ray; 2.80 A; E/F/G/H=2-443 # PDB 1YYF X-ray; 4.16 A; A/B=1-443 # PIR JT0761 JT0761 # Pfam PF00004 AAA # Pfam PF07724 AAA_2 # Pfam PF10431 ClpB_D2-small # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HSLU_ECOLI ATP-dependent protease ATPase subunit HslU # RefSeq NP_418366 NC_000913.3 # RefSeq WP_001293341 NZ_LN832404.1 # SIMILARITY Belongs to the ClpX chaperone family. HslU subfamily. {ECO 0000305}. # SMART SM00382 AAA # SMART SM01086 ClpB_D2-small # SUBCELLULAR LOCATION HSLU_ECOLI Cytoplasm. # SUBUNIT HSLU_ECOLI A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP. {ECO 0000269|PubMed 11709174, ECO 0000269|PubMed 15983416}. # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR00390 hslU # eggNOG COG1220 LUCA # eggNOG ENOG4105C4N Bacteria BLAST swissprot:HSLU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HSLU_ECOLI BioCyc ECOL316407:JW3902-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3902-MONOMER BioCyc EcoCyc:EG11881-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11881-MONOMER BioCyc MetaCyc:EG11881-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11881-MONOMER COG COG1220 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1220 DIP DIP-31855N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31855N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/bbrc.1997.7341 http://dx.doi.org/10.1006/bbrc.1997.7341 DOI 10.1016/0378-1119(93)90167-2 http://dx.doi.org/10.1016/0378-1119(93)90167-2 DOI 10.1016/S0014-5793(96)01223-9 http://dx.doi.org/10.1016/S0014-5793(96)01223-9 DOI 10.1016/S0014-5793(99)00935-7 http://dx.doi.org/10.1016/S0014-5793(99)00935-7 DOI 10.1016/S0969-2126(01)00670-0 http://dx.doi.org/10.1016/S0969-2126(01)00670-0 DOI 10.1038/35001629 http://dx.doi.org/10.1038/35001629 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsmb898 http://dx.doi.org/10.1038/nsmb898 DOI 10.1073/pnas.250491797 http://dx.doi.org/10.1073/pnas.250491797 DOI 10.1073/pnas.93.12.5808 http://dx.doi.org/10.1073/pnas.93.12.5808 DOI 10.1074/jbc.271.24.14035 http://dx.doi.org/10.1074/jbc.271.24.14035 DOI 10.1074/jbc.273.36.22929 http://dx.doi.org/10.1074/jbc.273.36.22929 DOI 10.1074/jbc.274.31.22002 http://dx.doi.org/10.1074/jbc.274.31.22002 DOI 10.1074/jbc.M109.045807 http://dx.doi.org/10.1074/jbc.M109.045807 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1107/S0907444905009546 http://dx.doi.org/10.1107/S0907444905009546 DOI 10.1111/j.1432-1033.1997.01143.x http://dx.doi.org/10.1111/j.1432-1033.1997.01143.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DisProt DP00100 http://www.disprot.org/protein.php?id=DP00100 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1827 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1827 EcoGene EG11881 http://www.ecogene.org/geneInfo.php?eg_id=EG11881 EnsemblBacteria AAC76913 http://www.ensemblgenomes.org/id/AAC76913 EnsemblBacteria AAC76913 http://www.ensemblgenomes.org/id/AAC76913 EnsemblBacteria BAE77379 http://www.ensemblgenomes.org/id/BAE77379 EnsemblBacteria BAE77379 http://www.ensemblgenomes.org/id/BAE77379 EnsemblBacteria BAE77379 http://www.ensemblgenomes.org/id/BAE77379 EnsemblBacteria b3931 http://www.ensemblgenomes.org/id/b3931 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0009376 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009376 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_function GO:0070011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070011 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GO_process GO:0043335 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043335 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948430 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948430 HAMAP MF_00249 http://hamap.expasy.org/unirule/MF_00249 HOGENOM HOG000010036 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000010036&db=HOGENOM6 InParanoid P0A6H5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6H5 IntAct P0A6H5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6H5* InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR003959 http://www.ebi.ac.uk/interpro/entry/IPR003959 InterPro IPR004491 http://www.ebi.ac.uk/interpro/entry/IPR004491 InterPro IPR019489 http://www.ebi.ac.uk/interpro/entry/IPR019489 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW3902 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3902 KEGG_Gene eco:b3931 http://www.genome.jp/dbget-bin/www_bget?eco:b3931 KEGG_Orthology KO:K03667 http://www.genome.jp/dbget-bin/www_bget?KO:K03667 OMA AKIMELP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AKIMELP PANTHER PTHR11262:SF3 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11262:SF3 PDB 1DO0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1DO0 PDB 1DO2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1DO2 PDB 1E94 http://www.ebi.ac.uk/pdbe-srv/view/entry/1E94 PDB 1G4A http://www.ebi.ac.uk/pdbe-srv/view/entry/1G4A PDB 1G4B http://www.ebi.ac.uk/pdbe-srv/view/entry/1G4B PDB 1HQY http://www.ebi.ac.uk/pdbe-srv/view/entry/1HQY PDB 1HT1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1HT1 PDB 1HT2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1HT2 PDB 1YYF http://www.ebi.ac.uk/pdbe-srv/view/entry/1YYF PDBsum 1DO0 http://www.ebi.ac.uk/pdbsum/1DO0 PDBsum 1DO2 http://www.ebi.ac.uk/pdbsum/1DO2 PDBsum 1E94 http://www.ebi.ac.uk/pdbsum/1E94 PDBsum 1G4A http://www.ebi.ac.uk/pdbsum/1G4A PDBsum 1G4B http://www.ebi.ac.uk/pdbsum/1G4B PDBsum 1HQY http://www.ebi.ac.uk/pdbsum/1HQY PDBsum 1HT1 http://www.ebi.ac.uk/pdbsum/1HT1 PDBsum 1HT2 http://www.ebi.ac.uk/pdbsum/1HT2 PDBsum 1YYF http://www.ebi.ac.uk/pdbsum/1YYF PSORT swissprot:HSLU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HSLU_ECOLI PSORT-B swissprot:HSLU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HSLU_ECOLI PSORT2 swissprot:HSLU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HSLU_ECOLI Pfam PF00004 http://pfam.xfam.org/family/PF00004 Pfam PF07724 http://pfam.xfam.org/family/PF07724 Pfam PF10431 http://pfam.xfam.org/family/PF10431 Phobius swissprot:HSLU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HSLU_ECOLI PhylomeDB P0A6H5 http://phylomedb.org/?seqid=P0A6H5 ProteinModelPortal P0A6H5 http://www.proteinmodelportal.org/query/uniprot/P0A6H5 PubMed 10419524 http://www.ncbi.nlm.nih.gov/pubmed/10419524 PubMed 10452560 http://www.ncbi.nlm.nih.gov/pubmed/10452560 PubMed 10693812 http://www.ncbi.nlm.nih.gov/pubmed/10693812 PubMed 11114186 http://www.ncbi.nlm.nih.gov/pubmed/11114186 PubMed 11709174 http://www.ncbi.nlm.nih.gov/pubmed/11709174 PubMed 15696175 http://www.ncbi.nlm.nih.gov/pubmed/15696175 PubMed 15983416 http://www.ncbi.nlm.nih.gov/pubmed/15983416 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19801685 http://www.ncbi.nlm.nih.gov/pubmed/19801685 PubMed 8244018 http://www.ncbi.nlm.nih.gov/pubmed/8244018 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 8650174 http://www.ncbi.nlm.nih.gov/pubmed/8650174 PubMed 8662828 http://www.ncbi.nlm.nih.gov/pubmed/8662828 PubMed 8977096 http://www.ncbi.nlm.nih.gov/pubmed/8977096 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9288941 http://www.ncbi.nlm.nih.gov/pubmed/9288941 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9299555 http://www.ncbi.nlm.nih.gov/pubmed/9299555 PubMed 9393683 http://www.ncbi.nlm.nih.gov/pubmed/9393683 PubMed 9722513 http://www.ncbi.nlm.nih.gov/pubmed/9722513 RefSeq NP_418366 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418366 RefSeq WP_001293341 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001293341 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMART SM01086 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01086 SMR P0A6H5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6H5 STRING 511145.b3931 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3931&targetmode=cogs STRING COG1220 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1220&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SWISS-2DPAGE P0A6H5 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A6H5 TIGRFAMs TIGR00390 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00390 UniProtKB HSLU_ECOLI http://www.uniprot.org/uniprot/HSLU_ECOLI UniProtKB-AC P0A6H5 http://www.uniprot.org/uniprot/P0A6H5 charge swissprot:HSLU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HSLU_ECOLI eggNOG COG1220 http://eggnogapi.embl.de/nog_data/html/tree/COG1220 eggNOG ENOG4105C4N http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C4N epestfind swissprot:HSLU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HSLU_ECOLI garnier swissprot:HSLU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HSLU_ECOLI helixturnhelix swissprot:HSLU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HSLU_ECOLI hmoment swissprot:HSLU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HSLU_ECOLI iep swissprot:HSLU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HSLU_ECOLI inforesidue swissprot:HSLU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HSLU_ECOLI octanol swissprot:HSLU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HSLU_ECOLI pepcoil swissprot:HSLU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HSLU_ECOLI pepdigest swissprot:HSLU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HSLU_ECOLI pepinfo swissprot:HSLU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HSLU_ECOLI pepnet swissprot:HSLU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HSLU_ECOLI pepstats swissprot:HSLU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HSLU_ECOLI pepwheel swissprot:HSLU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HSLU_ECOLI pepwindow swissprot:HSLU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HSLU_ECOLI sigcleave swissprot:HSLU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HSLU_ECOLI ## Database ID URL or Descriptions # BioGrid 4261369 379 # CDD cd06261 TM_PBP2 # EcoGene EG10676 oppC # FUNCTION OPPC_ECOLI Part of the binding-protein-dependent transport system for oligopeptides; probably responsible for the translocation of the substrate across the membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0022857 transmembrane transporter activity; IBA:GO_Central. # GO_process GO:0015031 protein transport; IEA:UniProtKB-KW. # GO_process GO:0015833 peptide transport; IEA:UniProtKB-KW. # GO_process GO:0055085 transmembrane transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # Gene3D 1.10.3720.10 -; 1. # InterPro IPR000515 MetI-like # InterPro IPR025966 OppC_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00439 Oligopeptide transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism OPPC_ECOLI Escherichia coli (strain K12) # PATRIC 32117750 VBIEscCol129921_1295 # PIR H64871 H64871 # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Pfam PF12911 OppC_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName OPPC_ECOLI Oligopeptide transport system permease protein OppC # RefSeq NP_415761 NC_000913.3 # RefSeq WP_000979661 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION OPPC_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF161098 SSF161098 # TCDB 3.A.1.5.41 the atp-binding cassette (abc) superfamily # eggNOG COG1173 LUCA # eggNOG ENOG4105C2T Bacteria BLAST swissprot:OPPC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:OPPC_ECOLI BioCyc ECOL316407:JW1237-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1237-MONOMER BioCyc EcoCyc:OPPC-MONOMER http://biocyc.org/getid?id=EcoCyc:OPPC-MONOMER BioCyc MetaCyc:OPPC-MONOMER http://biocyc.org/getid?id=MetaCyc:OPPC-MONOMER COG COG1173 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1173 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0670 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0670 EcoGene EG10676 http://www.ecogene.org/geneInfo.php?eg_id=EG10676 EnsemblBacteria AAC74327 http://www.ensemblgenomes.org/id/AAC74327 EnsemblBacteria AAC74327 http://www.ensemblgenomes.org/id/AAC74327 EnsemblBacteria BAA14777 http://www.ensemblgenomes.org/id/BAA14777 EnsemblBacteria BAA14777 http://www.ensemblgenomes.org/id/BAA14777 EnsemblBacteria BAA14777 http://www.ensemblgenomes.org/id/BAA14777 EnsemblBacteria b1245 http://www.ensemblgenomes.org/id/b1245 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GO_process GO:0015031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031 GO_process GO:0015833 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015833 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 945810 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945810 HOGENOM HOG000171367 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000171367&db=HOGENOM6 InParanoid P0AFH6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFH6 InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 InterPro IPR025966 http://www.ebi.ac.uk/interpro/entry/IPR025966 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1237 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1237 KEGG_Gene eco:b1245 http://www.genome.jp/dbget-bin/www_bget?eco:b1245 KEGG_Orthology KO:K15582 http://www.genome.jp/dbget-bin/www_bget?KO:K15582 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA IVVRHIV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IVVRHIV PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:OPPC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:OPPC_ECOLI PSORT-B swissprot:OPPC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:OPPC_ECOLI PSORT2 swissprot:OPPC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:OPPC_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Pfam PF12911 http://pfam.xfam.org/family/PF12911 Phobius swissprot:OPPC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:OPPC_ECOLI PhylomeDB P0AFH6 http://phylomedb.org/?seqid=P0AFH6 ProteinModelPortal P0AFH6 http://www.proteinmodelportal.org/query/uniprot/P0AFH6 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415761 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415761 RefSeq WP_000979661 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000979661 SMR P0AFH6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFH6 STRING 511145.b1245 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1245&targetmode=cogs STRING COG1173 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1173&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.5.41 http://www.tcdb.org/search/result.php?tc=3.A.1.5.41 UniProtKB OPPC_ECOLI http://www.uniprot.org/uniprot/OPPC_ECOLI UniProtKB-AC P0AFH6 http://www.uniprot.org/uniprot/P0AFH6 charge swissprot:OPPC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:OPPC_ECOLI eggNOG COG1173 http://eggnogapi.embl.de/nog_data/html/tree/COG1173 eggNOG ENOG4105C2T http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C2T epestfind swissprot:OPPC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:OPPC_ECOLI garnier swissprot:OPPC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:OPPC_ECOLI helixturnhelix swissprot:OPPC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:OPPC_ECOLI hmoment swissprot:OPPC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:OPPC_ECOLI iep swissprot:OPPC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:OPPC_ECOLI inforesidue swissprot:OPPC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:OPPC_ECOLI octanol swissprot:OPPC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:OPPC_ECOLI pepcoil swissprot:OPPC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:OPPC_ECOLI pepdigest swissprot:OPPC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:OPPC_ECOLI pepinfo swissprot:OPPC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:OPPC_ECOLI pepnet swissprot:OPPC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:OPPC_ECOLI pepstats swissprot:OPPC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:OPPC_ECOLI pepwheel swissprot:OPPC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:OPPC_ECOLI pepwindow swissprot:OPPC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:OPPC_ECOLI sigcleave swissprot:OPPC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:OPPC_ECOLI ## Database ID URL or Descriptions # AltName HNS_ECOLI Histone-like protein HLP-II # AltName Heat-stable nucleoid-structuring protein {ECO:0000303|PubMed 6395665} # AltName Protein B1 {ECO:0000303|PubMed 333393} # AltName Protein H1 {ECO:0000303|PubMed 4566454} # BioGrid 4263496 32 # DISRUPTION PHENOTYPE HNS_ECOLI Decreased growth below 30 degrees Celsius (PubMed 1691451). Altered expression of a number of genes (PubMed 2128918, PubMed 8890170, PubMed 8913298, PubMed 23543115). Derepression of the cryptic blg operon (PubMed 8913298, PubMed 11790731). Alteration of chromosome organization (PubMed 21903814). Double hns-stpA mutants grow slower and have reduced viable cell counts compared to single hns mutants in MC1029 and MC4100 backgrounds (PubMed 8890170). In 0.3M NaCl a double hns-stpA deletion up-regulates 583 and down-regulates 86 genes, 363 of which are thought to have been horizontally acquired; 131 are also up-regulated in a double cnu-hha deletion (PubMed 23543115). At 28 degrees Celsius csgD transcription is reduced (PubMed 17010156). Flagella loss due to reduced expression of the flhDC operon (PubMed 11031114). Flagella can be restored by expression of flhDC, but strains are non-motile, suggesting H-NS also plays a role in flagellar function (PubMed 11031114). Disruption leads to increased expression of CRISPR-cas genes and increased viral resistance (PubMed 20659289). {ECO 0000269|PubMed 11031114, ECO 0000269|PubMed 11790731, ECO 0000269|PubMed 1691451, ECO 0000269|PubMed 17010156, ECO 0000269|PubMed 20659289, ECO 0000269|PubMed 2128918, ECO 0000269|PubMed 21903814, ECO 0000269|PubMed 23543115, ECO 0000269|PubMed 8890170, ECO 0000269|PubMed 8913298}. # DOMAIN HNS_ECOLI A central region (about residues 21-47) is involved in dimerization, but multimerization requires other residues (PubMed 8755860, PubMed 9398522, PubMed 16650431, PubMed 12460581, PubMed 12592399). The dimerization domain (1-47) also acts as a hinge; changes in its structure probably impact oligomerization and DNA-binding geometries (PubMed 23601147). The N-terminus also interacts with Hha, perhaps via residues 2-18; a well-folded dimer is not necessary for Hha binding (PubMed 16650431). The C-terminus (residues 92-137) binds DNA (PubMed 8913298). Residues in the N- terminus contribute to DNA-binding and to discrimination between curved and non-curved DNA (PubMed 12592399). {ECO 0000269|PubMed 12460581, ECO 0000269|PubMed 12592399, ECO 0000269|PubMed 16650431, ECO 0000269|PubMed 23601147, ECO 0000269|PubMed 8755860, ECO 0000269|PubMed 8913298, ECO 0000269|PubMed 9398522}. # EcoGene EG10457 hns # FUNCTION HNS_ECOLI A DNA-binding protein implicated in transcriptional repression (silencing) (PubMed 333393, PubMed 2128918, PubMed 8890170, PubMed 8913298, PubMed 9398522, PubMed 16963779, PubMed 17046956, PubMed 23543115). Also involved in bacterial chromosome organization and compaction (PubMed 6379600, PubMed 10982869, PubMed 21903814). H-NS binds tightly to AT-rich dsDNA and inhibits transcription (PubMed 2512122, PubMed 16963779, PubMed 17435766, PubMed 17881364, PubMed 23543115). Binds upstream and downstream of initiating RNA polymerase, trapping it in a loop and preventing transcription (PubMed 11714691). Binds to hundreds of sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome (PubMed 16963779, PubMed 17046956, PubMed 23543115). Many of these loci were horizontally transferred (HTG); this offers the selective advantage of silencing foreign DNA while keeping it in the genome in case of need (PubMed 17046956, PubMed 17881364, PubMed 26789284). Suppresses transcription at many intragenic sites as well as transcription of spurious, non-coding RNAs genome-wide (PubMed 24449106). Repression of HTG by H-NS is thought to allow their DNA to evolve faster than non-H-NS-bound regions, and facilitates integration of HTG into transcriptional regulatory networks (PubMed 26789284). A subset of H-NS/StpA- regulated genes also require Hha (and/or Cnu, ydgT) for repression; Hha and Cnu increase the number of genes DNA bound by H-NS/StpA and may also modulate the oligomerization of the H- NS/StpA-complex (PubMed 23543115). The protein forms 2 clusters in the nucleoid which gather hns-bound loci together, bridging non- contiguous DNA, and causes DNA substantial condensation (PubMed 21903814). Binds DNA better at low temperatures than at 37 degrees Celsius; AT-rich sites nucleate H-NS binding, further DNA- binding is cooperative and this cooperativity decreases with rising temperature (PubMed 17435766, PubMed 17881364). Transcriptional repression can be inhibited by dominant-negative mutants of StpA or itself (PubMed 8755860). May effect transcriptional elongation (PubMed 25638302). Can increase translational efficiency of mRNA with suboptimal Shine-Dalgarno sequences (PubMed 20595230). Plays a role in the thermal control of pili and adhesive curli fimbriae production, by inducing transcription of csgD (PubMed 17010156). Plays a role in flagellar function (PubMed 11031114). Represses the CRISPR-cas promoters, permits only weak transcription of the crRNA precursor; its repression is antagonized by LeuO (PubMed 20132443, PubMed 20659289). Binds preferentially to the upstream region of its own gene recognizing two segments of DNA on both sides of a bend centered around -150 (PubMed 7934818). Overexpression suppresses secY24, a temperature-sensitive mutation (PubMed 1537791). Has also been reported to activate transcription of some genes (PubMed 4566454, PubMed 338303, PubMed 2128918). {ECO 0000269|PubMed 10982869, ECO 0000269|PubMed 11031114, ECO 0000269|PubMed 11714691, ECO 0000269|PubMed 1537791, ECO 0000269|PubMed 16963779, ECO 0000269|PubMed 17010156, ECO 0000269|PubMed 17046956, ECO 0000269|PubMed 17435766, ECO 0000269|PubMed 17881364, ECO 0000269|PubMed 20132443, ECO 0000269|PubMed 20595230, ECO 0000269|PubMed 20659289, ECO 0000269|PubMed 2128918, ECO 0000269|PubMed 21903814, ECO 0000269|PubMed 23543115, ECO 0000269|PubMed 24449106, ECO 0000269|PubMed 2512122, ECO 0000269|PubMed 26789284, ECO 0000269|PubMed 333393, ECO 0000269|PubMed 338303, ECO 0000269|PubMed 4566454, ECO 0000269|PubMed 6379600, ECO 0000269|PubMed 7934818, ECO 0000269|PubMed 8755860, ECO 0000269|PubMed 8890170, ECO 0000269|PubMed 8913298, ECO 0000269|PubMed 9398522, ECO 0000305|PubMed 25638302}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0009295 nucleoid; IEA:UniProtKB-SubCell. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0003681 bent DNA binding; IDA:EcoliWiki. # GO_function GO:0003723 RNA binding; IEA:UniProtKB-KW. # GO_function GO:0042802 identical protein binding; IPI:IntAct. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006417 regulation of translation; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0003723 RNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.287.1050 -; 1. # Gene3D 4.10.430.10 -; 1. # INDUCTION HNS_ECOLI Protein levels rise from about 4,000/cell in exponential phase to about 18,000/cell in late stationary phase (at protein level) (PubMed 6379600). Subject to transcriptional auto-repression (PubMed 7934818). Induced by increased hydrostatic pressure (PubMed 8226663). hns transcription can be repressed by overexpressed StpA (which is usually repressed by hns) (PubMed 8890170). {ECO 0000269|PubMed 6379600, ECO 0000269|PubMed 7934818, ECO 0000269|PubMed 8226663, ECO 0000269|PubMed 8890170}. # INTERACTION HNS_ECOLI Self; NbExp=10; IntAct=EBI-544934, EBI-544934; P64467 cnu; NbExp=2; IntAct=EBI-544934, EBI-551907; P0ACE3 hha; NbExp=5; IntAct=EBI-544934, EBI-1122578; P0ACG1 stpA; NbExp=3; IntAct=EBI-544934, EBI-551928; # IntAct P0ACF8 49 # InterPro IPR001801 Histone_HNS # InterPro IPR027444 H-NS_C_dom # InterPro IPR027454 Histone_HNS_oligo_dom # KEGG_Brite ko03036 Chromosome # KEGG_Brite ko03400 DNA repair and recombination proteins # MASS SPECTROMETRY Mass=15407.8; Method=MALDI; Range=2-137; Note=A second experiment gave a mass of 15410.1.; Evidence={ECO:0000269|PubMed 11790731}; # Organism HNS_ECOLI Escherichia coli (strain K12) # PATRIC 32117730 VBIEscCol129921_1285 # PDB 1HNR NMR; -; A=91-137 # PDB 1HNS NMR; -; A=91-137 # PDB 1LR1 NMR; -; A/B=2-58 # PDB 1NI8 NMR; -; A/B=2-47 # PDB 2MW2 NMR; -; B/C=1-47 # PIR S00903 S00903 # PIRSF PIRSF002096 HnS # PTM HNS_ECOLI Cells (strain MRE-600) in mid-exponential phase have three 15.5 kDa proteins with 3 different isoelectric points; the major form (H1a, pI 7.5) rises in concentration during growth while the 2 minor forms (H1b, pI about 7.2 and H1c, pI 7.0) remain approximately constant (PubMed 6379600). {ECO 0000269|PubMed 6379600}. # Pfam PF00816 Histone_HNS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DNA-binding protein H-NS {ECO:0000303|PubMed 2841565} # RefSeq NP_415753 NC_000913.3 # RefSeq WP_001287378 NZ_LN832404.1 # SIMILARITY Belongs to the histone-like protein H-NS family. {ECO 0000305}. # SMART SM00528 HNS # SUBCELLULAR LOCATION HNS_ECOLI Cytoplasm, nucleoid {ECO 0000269|PubMed 21903814, ECO 0000269|PubMed 333393}. Note=Forms 2 compact clusters per chromosome, located at one- quarter and three-quarter positions on the cell's long axis 2 H- NS-repressed genes were closely associated with H-NS clusters while a non-H-NS-repressed gene was not substantially associated with the H-NS cluster (PubMed 21903814). {ECO 0000269|PubMed 21903814}. # SUBUNIT HNS_ECOLI Homodimer, also found as tetramers or higher oligomers (PubMed 4566454, PubMed 338303, PubMed 3135462, PubMed 8913298, PubMed 9398522, PubMed 8755860, PubMed 12460581, PubMed 23601147). Oligomerizes into higher-order complexes that form bridges between adjacent DNA helices. The N-terminal region (residues 1-64) can interact with overexpressed StpA (PubMed 8755860). Forms a complex with Cnu (YdgT) (PubMed 21600204). The H-NS dimer forms a heterotrimeric complex with Hha in the absence of DNA; this is mediated by residues 1-46 (PubMed 21600204, PubMed 11790731, PubMed 16650431, PubMed 26085102). Interacts with Hfq (PubMed 2020545). {ECO 0000269|PubMed 11790731, ECO 0000269|PubMed 16650431, ECO 0000269|PubMed 2020545, ECO 0000269|PubMed 21600204, ECO 0000269|PubMed 23601147, ECO 0000269|PubMed 26085102, ECO 0000269|PubMed 3135462, ECO 0000269|PubMed 338303, ECO 0000269|PubMed 4566454, ECO 0000269|PubMed 8755860, ECO 0000269|PubMed 8913298, ECO 0000269|PubMed 9398522, ECO 0000305|PubMed 12460581}. # eggNOG COG2916 LUCA # eggNOG ENOG4108SAU Bacteria BLAST swissprot:HNS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HNS_ECOLI BioCyc ECOL316407:JW1225-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1225-MONOMER BioCyc EcoCyc:PD00288 http://biocyc.org/getid?id=EcoCyc:PD00288 COG COG2916 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2916 DIP DIP-35853N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35853N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 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10.1126/science.1204697 http://dx.doi.org/10.1126/science.1204697 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.3.629-635.2002 http://dx.doi.org/10.1128/JB.184.3.629-635.2002 DOI 10.1371/journal.pgen.1005796 http://dx.doi.org/10.1371/journal.pgen.1005796 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X07688 http://www.ebi.ac.uk/ena/data/view/X07688 EMBL X57231 http://www.ebi.ac.uk/ena/data/view/X57231 EMBL X59940 http://www.ebi.ac.uk/ena/data/view/X59940 EMBL X67326 http://www.ebi.ac.uk/ena/data/view/X67326 EMBL Y00976 http://www.ebi.ac.uk/ena/data/view/Y00976 EchoBASE EB0452 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0452 EcoGene EG10457 http://www.ecogene.org/geneInfo.php?eg_id=EG10457 EnsemblBacteria AAC74319 http://www.ensemblgenomes.org/id/AAC74319 EnsemblBacteria AAC74319 http://www.ensemblgenomes.org/id/AAC74319 EnsemblBacteria BAA36117 http://www.ensemblgenomes.org/id/BAA36117 EnsemblBacteria BAA36117 http://www.ensemblgenomes.org/id/BAA36117 EnsemblBacteria BAA36117 http://www.ensemblgenomes.org/id/BAA36117 EnsemblBacteria b1237 http://www.ensemblgenomes.org/id/b1237 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0009295 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009295 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0003681 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003681 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0006417 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006417 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.287.1050 http://www.cathdb.info/version/latest/superfamily/1.10.287.1050 Gene3D 4.10.430.10 http://www.cathdb.info/version/latest/superfamily/4.10.430.10 GeneID 945829 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945829 HOGENOM HOG000218473 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218473&db=HOGENOM6 IntAct P0ACF8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACF8* InterPro IPR001801 http://www.ebi.ac.uk/interpro/entry/IPR001801 InterPro IPR027444 http://www.ebi.ac.uk/interpro/entry/IPR027444 InterPro IPR027454 http://www.ebi.ac.uk/interpro/entry/IPR027454 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW1225 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1225 KEGG_Gene eco:b1237 http://www.genome.jp/dbget-bin/www_bget?eco:b1237 KEGG_Orthology KO:K03746 http://www.genome.jp/dbget-bin/www_bget?KO:K03746 MINT MINT-1223907 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1223907 OMA NGVEKTW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NGVEKTW PDB 1HNR http://www.ebi.ac.uk/pdbe-srv/view/entry/1HNR PDB 1HNS http://www.ebi.ac.uk/pdbe-srv/view/entry/1HNS PDB 1LR1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1LR1 PDB 1NI8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1NI8 PDB 2MW2 http://www.ebi.ac.uk/pdbe-srv/view/entry/2MW2 PDBsum 1HNR http://www.ebi.ac.uk/pdbsum/1HNR PDBsum 1HNS http://www.ebi.ac.uk/pdbsum/1HNS PDBsum 1LR1 http://www.ebi.ac.uk/pdbsum/1LR1 PDBsum 1NI8 http://www.ebi.ac.uk/pdbsum/1NI8 PDBsum 2MW2 http://www.ebi.ac.uk/pdbsum/2MW2 PSORT swissprot:HNS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HNS_ECOLI PSORT-B swissprot:HNS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HNS_ECOLI PSORT2 swissprot:HNS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HNS_ECOLI Pfam PF00816 http://pfam.xfam.org/family/PF00816 Phobius swissprot:HNS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HNS_ECOLI ProteinModelPortal P0ACF8 http://www.proteinmodelportal.org/query/uniprot/P0ACF8 PubMed 10982869 http://www.ncbi.nlm.nih.gov/pubmed/10982869 PubMed 11031114 http://www.ncbi.nlm.nih.gov/pubmed/11031114 PubMed 11714691 http://www.ncbi.nlm.nih.gov/pubmed/11714691 PubMed 11790731 http://www.ncbi.nlm.nih.gov/pubmed/11790731 PubMed 12460581 http://www.ncbi.nlm.nih.gov/pubmed/12460581 PubMed 12592399 http://www.ncbi.nlm.nih.gov/pubmed/12592399 PubMed 1537791 http://www.ncbi.nlm.nih.gov/pubmed/1537791 PubMed 16650431 http://www.ncbi.nlm.nih.gov/pubmed/16650431 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1691451 http://www.ncbi.nlm.nih.gov/pubmed/1691451 PubMed 16963779 http://www.ncbi.nlm.nih.gov/pubmed/16963779 PubMed 17010156 http://www.ncbi.nlm.nih.gov/pubmed/17010156 PubMed 17046956 http://www.ncbi.nlm.nih.gov/pubmed/17046956 PubMed 17435766 http://www.ncbi.nlm.nih.gov/pubmed/17435766 PubMed 17881364 http://www.ncbi.nlm.nih.gov/pubmed/17881364 PubMed 20132443 http://www.ncbi.nlm.nih.gov/pubmed/20132443 PubMed 2020545 http://www.ncbi.nlm.nih.gov/pubmed/2020545 PubMed 20595230 http://www.ncbi.nlm.nih.gov/pubmed/20595230 PubMed 20659289 http://www.ncbi.nlm.nih.gov/pubmed/20659289 PubMed 2126011 http://www.ncbi.nlm.nih.gov/pubmed/2126011 PubMed 2128918 http://www.ncbi.nlm.nih.gov/pubmed/2128918 PubMed 21600204 http://www.ncbi.nlm.nih.gov/pubmed/21600204 PubMed 2177526 http://www.ncbi.nlm.nih.gov/pubmed/2177526 PubMed 21903814 http://www.ncbi.nlm.nih.gov/pubmed/21903814 PubMed 23543115 http://www.ncbi.nlm.nih.gov/pubmed/23543115 PubMed 23601147 http://www.ncbi.nlm.nih.gov/pubmed/23601147 PubMed 24449106 http://www.ncbi.nlm.nih.gov/pubmed/24449106 PubMed 2494066 http://www.ncbi.nlm.nih.gov/pubmed/2494066 PubMed 2512122 http://www.ncbi.nlm.nih.gov/pubmed/2512122 PubMed 25638302 http://www.ncbi.nlm.nih.gov/pubmed/25638302 PubMed 26085102 http://www.ncbi.nlm.nih.gov/pubmed/26085102 PubMed 26789284 http://www.ncbi.nlm.nih.gov/pubmed/26789284 PubMed 2841565 http://www.ncbi.nlm.nih.gov/pubmed/2841565 PubMed 3135462 http://www.ncbi.nlm.nih.gov/pubmed/3135462 PubMed 333393 http://www.ncbi.nlm.nih.gov/pubmed/333393 PubMed 338303 http://www.ncbi.nlm.nih.gov/pubmed/338303 PubMed 4566454 http://www.ncbi.nlm.nih.gov/pubmed/4566454 PubMed 6370250 http://www.ncbi.nlm.nih.gov/pubmed/6370250 PubMed 6379600 http://www.ncbi.nlm.nih.gov/pubmed/6379600 PubMed 6395665 http://www.ncbi.nlm.nih.gov/pubmed/6395665 PubMed 7773397 http://www.ncbi.nlm.nih.gov/pubmed/7773397 PubMed 7875316 http://www.ncbi.nlm.nih.gov/pubmed/7875316 PubMed 7934818 http://www.ncbi.nlm.nih.gov/pubmed/7934818 PubMed 8226663 http://www.ncbi.nlm.nih.gov/pubmed/8226663 PubMed 8755860 http://www.ncbi.nlm.nih.gov/pubmed/8755860 PubMed 8890170 http://www.ncbi.nlm.nih.gov/pubmed/8890170 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 8913298 http://www.ncbi.nlm.nih.gov/pubmed/8913298 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9398522 http://www.ncbi.nlm.nih.gov/pubmed/9398522 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 PubMed 9868784 http://www.ncbi.nlm.nih.gov/pubmed/9868784 RefSeq NP_415753 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415753 RefSeq WP_001287378 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001287378 SMART SM00528 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00528 SMR P0ACF8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACF8 STRING 511145.b1237 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1237&targetmode=cogs STRING COG2916 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2916&targetmode=cogs SWISS-2DPAGE P0ACF8 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0ACF8 UniProtKB HNS_ECOLI http://www.uniprot.org/uniprot/HNS_ECOLI UniProtKB-AC P0ACF8 http://www.uniprot.org/uniprot/P0ACF8 charge swissprot:HNS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HNS_ECOLI eggNOG COG2916 http://eggnogapi.embl.de/nog_data/html/tree/COG2916 eggNOG ENOG4108SAU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108SAU epestfind swissprot:HNS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HNS_ECOLI garnier swissprot:HNS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HNS_ECOLI helixturnhelix swissprot:HNS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HNS_ECOLI hmoment swissprot:HNS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HNS_ECOLI iep swissprot:HNS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HNS_ECOLI inforesidue swissprot:HNS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HNS_ECOLI octanol swissprot:HNS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HNS_ECOLI pepcoil swissprot:HNS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HNS_ECOLI pepdigest swissprot:HNS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HNS_ECOLI pepinfo swissprot:HNS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HNS_ECOLI pepnet swissprot:HNS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HNS_ECOLI pepstats swissprot:HNS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HNS_ECOLI pepwheel swissprot:HNS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HNS_ECOLI pepwindow swissprot:HNS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HNS_ECOLI sigcleave swissprot:HNS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HNS_ECOLI ## Database ID URL or Descriptions # BioGrid 4262191 26 # EcoGene EG14423 yniD # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # INDUCTION YNID_ECOLI Constitutively expressed (at protein level). {ECO 0000269|PubMed 19121005, ECO 0000269|PubMed 19734316}. # Organism YNID_ECOLI Escherichia coli (strain K12) # PATRIC 32118749 VBIEscCol129921_1792 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNID_ECOLI Uncharacterized protein YniD # RefSeq WP_001142445 NZ_LN832404.1 # RefSeq YP_588455 NC_000913.3 # SEQUENCE CAUTION Sequence=BAE76507.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SUBCELLULAR LOCATION YNID_ECOLI Membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. BLAST swissprot:YNID_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNID_ECOLI BioCyc ECOL316407:JW5911-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5911-MONOMER BioCyc EcoCyc:MONOMER0-2675 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2675 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2008.06495.x http://dx.doi.org/10.1111/j.1365-2958.2008.06495.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00872-09 http://dx.doi.org/10.1128/JB.00872-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14423 http://www.ecogene.org/geneInfo.php?eg_id=EG14423 EnsemblBacteria ABD18671 http://www.ensemblgenomes.org/id/ABD18671 EnsemblBacteria ABD18671 http://www.ensemblgenomes.org/id/ABD18671 EnsemblBacteria BAE76507 http://www.ensemblgenomes.org/id/BAE76507 EnsemblBacteria BAE76507 http://www.ensemblgenomes.org/id/BAE76507 EnsemblBacteria BAE76507 http://www.ensemblgenomes.org/id/BAE76507 EnsemblBacteria b4535 http://www.ensemblgenomes.org/id/b4535 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GeneID 1450269 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1450269 HOGENOM HOG000054899 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000054899&db=HOGENOM6 KEGG_Gene ecj:JW5911 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5911 KEGG_Gene eco:b4535 http://www.genome.jp/dbget-bin/www_bget?eco:b4535 PSORT swissprot:YNID_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNID_ECOLI PSORT-B swissprot:YNID_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNID_ECOLI PSORT2 swissprot:YNID_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNID_ECOLI Phobius swissprot:YNID_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNID_ECOLI PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19121005 http://www.ncbi.nlm.nih.gov/pubmed/19121005 PubMed 19734316 http://www.ncbi.nlm.nih.gov/pubmed/19734316 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001142445 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001142445 RefSeq YP_588455 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_588455 STRING 511145.b4535 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4535&targetmode=cogs UniProtKB YNID_ECOLI http://www.uniprot.org/uniprot/YNID_ECOLI UniProtKB-AC Q2EES1 http://www.uniprot.org/uniprot/Q2EES1 charge swissprot:YNID_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNID_ECOLI epestfind swissprot:YNID_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNID_ECOLI garnier swissprot:YNID_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNID_ECOLI helixturnhelix swissprot:YNID_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNID_ECOLI hmoment swissprot:YNID_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNID_ECOLI iep swissprot:YNID_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNID_ECOLI inforesidue swissprot:YNID_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNID_ECOLI octanol swissprot:YNID_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNID_ECOLI pepcoil swissprot:YNID_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNID_ECOLI pepdigest swissprot:YNID_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNID_ECOLI pepinfo swissprot:YNID_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNID_ECOLI pepnet swissprot:YNID_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNID_ECOLI pepstats swissprot:YNID_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNID_ECOLI pepwheel swissprot:YNID_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNID_ECOLI pepwindow swissprot:YNID_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNID_ECOLI sigcleave swissprot:YNID_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNID_ECOLI ## Database ID URL or Descriptions # BioGrid 4262281 240 # DISRUPTION PHENOTYPE Mutants form long filaments, but DNA segregation is not affected. {ECO:0000269|PubMed 11972052}. # DOMAIN FTSB_ECOLI The transmembrane segment and the membrane-proximal periplasmic region, which forms a coiled-coil structure, are required for interaction with FtsL and recruitment of downstream division proteins. The C-terminal region is required for interaction with FtsQ, but is not required for recruitment of the downstream division protein FtsI. Contains a leucine zipper-like (LZ) motif, which is required for optimal interaction with FtsL. {ECO 0000269|PubMed 19233928, ECO 0000269|PubMed 21784946}. # EcoGene EG13111 ftsB # FUNCTION FTSB_ECOLI Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. {ECO 0000255|HAMAP-Rule MF_00599, ECO 0000269|PubMed 11972052, ECO 0000269|PubMed 19233928}. # GO_component GO:0005887 integral component of plasma membrane; IEA:UniProtKB-HAMAP. # GO_component GO:0030428 cell septum; IDA:EcoliWiki. # GO_component GO:0032153 cell division site; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0043093 FtsZ-dependent cytokinesis; IMP:EcoCyc. # GO_process GO:0051301 cell division; IMP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0008150 biological_process # GOslim_process GO:0051301 cell division # HAMAP MF_00599 FtsB # INTERACTION FTSB_ECOLI P0AEN4 ftsL; NbExp=18; IntAct=EBI-1113953, EBI-1119082; P06136 ftsQ; NbExp=10; IntAct=EBI-1113953, EBI-1130157; # IntAct P0A6S5 8 # InterPro IPR007060 FtsL/DivIC # InterPro IPR023081 Cell_div_FtsB # KEGG_Brite ko03036 Chromosome # MISCELLANEOUS FTSB_ECOLI The C-terminal domain of FtsB is degraded in the absence of either FtsL or FtsQ. # Organism FTSB_ECOLI Escherichia coli (strain K12) # PATRIC 32120902 VBIEscCol129921_2843 # PDB 4IFF X-ray; 2.30 A; A/B/C/D=28-63 # PIR H65055 H65055 # Pfam PF04977 DivIC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Cell division protein FtsB {ECO:0000255|HAMAP-Rule MF_00599} # RefSeq NP_417228 NC_000913.3 # RefSeq WP_000517476 NZ_LN832404.1 # SIMILARITY Belongs to the FtsB family. {ECO:0000255|HAMAP- Rule MF_00599}. # SUBCELLULAR LOCATION FTSB_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_00599, ECO 0000269|PubMed 11972052, ECO 0000269|PubMed 15165235}; Single-pass type II membrane protein {ECO 0000255|HAMAP-Rule MF_00599, ECO 0000269|PubMed 11972052, ECO 0000269|PubMed 15165235}. Note=Localizes to the division septum. Localization requires FtsQ and FtsL, but not FtsW and FtsI. Localization of FtsB and FtsL is codependent. # SUBUNIT FTSB_ECOLI Part of a complex composed of FtsB, FtsL and FtsQ. The complex can be formed before its localization to the division site. This tripartite complex can be divided further into a subcomplex of FtsB and FtsL, which forms in the absence of FtsQ. Interacts also with FtsI and FtsN. {ECO 0000255|HAMAP- Rule MF_00599, ECO 0000269|PubMed 11972052, ECO 0000269|PubMed 15165235, ECO 0000269|PubMed 15774864, ECO 0000269|PubMed 19233928}. # eggNOG COG2919 LUCA # eggNOG ENOG4105XX3 Bacteria BLAST swissprot:FTSB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FTSB_ECOLI BioCyc ECOL316407:JW2718-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2718-MONOMER BioCyc EcoCyc:G7424-MONOMER http://biocyc.org/getid?id=EcoCyc:G7424-MONOMER COG COG2919 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2919 DIP DIP-12117N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12117N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.092128499 http://dx.doi.org/10.1073/pnas.092128499 DOI 10.1111/j.1365-2958.2004.04044.x http://dx.doi.org/10.1111/j.1365-2958.2004.04044.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00324-11 http://dx.doi.org/10.1128/JB.00324-11 DOI 10.1128/JB.01597-08 http://dx.doi.org/10.1128/JB.01597-08 DOI 10.1128/JB.187.7.2233-2243.2005 http://dx.doi.org/10.1128/JB.187.7.2233-2243.2005 DOI 10.1186/1472-6807-11-28 http://dx.doi.org/10.1186/1472-6807-11-28 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EchoBASE EB2914 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2914 EcoGene EG13111 http://www.ecogene.org/geneInfo.php?eg_id=EG13111 EnsemblBacteria AAC75790 http://www.ensemblgenomes.org/id/AAC75790 EnsemblBacteria AAC75790 http://www.ensemblgenomes.org/id/AAC75790 EnsemblBacteria BAE76825 http://www.ensemblgenomes.org/id/BAE76825 EnsemblBacteria BAE76825 http://www.ensemblgenomes.org/id/BAE76825 EnsemblBacteria BAE76825 http://www.ensemblgenomes.org/id/BAE76825 EnsemblBacteria b2748 http://www.ensemblgenomes.org/id/b2748 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0030428 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030428 GO_component GO:0032153 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032153 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0043093 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043093 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GeneID 946033 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946033 HAMAP MF_00599 http://hamap.expasy.org/unirule/MF_00599 HOGENOM HOG000262021 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000262021&db=HOGENOM6 InParanoid P0A6S5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6S5 IntAct P0A6S5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6S5* InterPro IPR007060 http://www.ebi.ac.uk/interpro/entry/IPR007060 InterPro IPR023081 http://www.ebi.ac.uk/interpro/entry/IPR023081 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene ecj:JW2718 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2718 KEGG_Gene eco:b2748 http://www.genome.jp/dbget-bin/www_bget?eco:b2748 KEGG_Orthology KO:K05589 http://www.genome.jp/dbget-bin/www_bget?KO:K05589 OMA DYVRVKD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DYVRVKD PDB 4IFF http://www.ebi.ac.uk/pdbe-srv/view/entry/4IFF PDBsum 4IFF http://www.ebi.ac.uk/pdbsum/4IFF PSORT swissprot:FTSB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FTSB_ECOLI PSORT-B swissprot:FTSB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FTSB_ECOLI PSORT2 swissprot:FTSB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FTSB_ECOLI Pfam PF04977 http://pfam.xfam.org/family/PF04977 Phobius swissprot:FTSB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FTSB_ECOLI PhylomeDB P0A6S5 http://phylomedb.org/?seqid=P0A6S5 ProteinModelPortal P0A6S5 http://www.proteinmodelportal.org/query/uniprot/P0A6S5 PubMed 11972052 http://www.ncbi.nlm.nih.gov/pubmed/11972052 PubMed 15165235 http://www.ncbi.nlm.nih.gov/pubmed/15165235 PubMed 15774864 http://www.ncbi.nlm.nih.gov/pubmed/15774864 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19233928 http://www.ncbi.nlm.nih.gov/pubmed/19233928 PubMed 21672257 http://www.ncbi.nlm.nih.gov/pubmed/21672257 PubMed 21784946 http://www.ncbi.nlm.nih.gov/pubmed/21784946 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417228 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417228 RefSeq WP_000517476 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000517476 SMR P0A6S5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6S5 STRING 511145.b2748 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2748&targetmode=cogs STRING COG2919 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2919&targetmode=cogs UniProtKB FTSB_ECOLI http://www.uniprot.org/uniprot/FTSB_ECOLI UniProtKB-AC P0A6S5 http://www.uniprot.org/uniprot/P0A6S5 charge swissprot:FTSB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FTSB_ECOLI eggNOG COG2919 http://eggnogapi.embl.de/nog_data/html/tree/COG2919 eggNOG ENOG4105XX3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105XX3 epestfind swissprot:FTSB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FTSB_ECOLI garnier swissprot:FTSB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FTSB_ECOLI helixturnhelix swissprot:FTSB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FTSB_ECOLI hmoment swissprot:FTSB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FTSB_ECOLI iep swissprot:FTSB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FTSB_ECOLI inforesidue swissprot:FTSB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FTSB_ECOLI octanol swissprot:FTSB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FTSB_ECOLI pepcoil swissprot:FTSB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FTSB_ECOLI pepdigest swissprot:FTSB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FTSB_ECOLI pepinfo swissprot:FTSB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FTSB_ECOLI pepnet swissprot:FTSB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FTSB_ECOLI pepstats swissprot:FTSB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FTSB_ECOLI pepwheel swissprot:FTSB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FTSB_ECOLI pepwindow swissprot:FTSB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FTSB_ECOLI sigcleave swissprot:FTSB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FTSB_ECOLI ## Database ID URL or Descriptions # BRENDA 2.3.1.30 2026 # BioGrid 4259493 32 # CATALYTIC ACTIVITY CYSE_ECOLI Acetyl-CoA + L-serine = CoA + O-acetyl-L- serine. # ENZYME REGULATION CYSE_ECOLI Sensitive to feedback inhibition by L-cysteine. # EcoGene EG10187 cysE # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0009333 cysteine synthase complex; IDA:EcoCyc. # GO_function GO:0009001 serine O-acetyltransferase activity; IDA:EcoCyc. # GO_process GO:0006535 cysteine biosynthetic process from serine; IDA:EcoCyc. # GO_process GO:0008652 cellular amino acid biosynthetic process; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # IntAct P0A9D4 2 # InterPro IPR001451 Hexapep # InterPro IPR005881 Ser_O-AcTrfase # InterPro IPR010493 Ser_AcTrfase_N # InterPro IPR011004 Trimer_LpxA-like # InterPro IPR018357 Hexapep_transf_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00270 Cysteine and methionine metabolism # KEGG_Pathway ko00920 Sulfur metabolism # Organism CYSE_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-cysteine biosynthesis; L- cysteine from L-serine step 1/2. # PATRIC 32122699 VBIEscCol129921_3726 # PDB 1T3D X-ray; 2.20 A; A/B/C=1-273 # PIR A27896 XYECSA # PROSITE PS00101 HEXAPEP_TRANSFERASES # Pfam PF00132 Hexapep # Pfam PF06426 SATase_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CYSE_ECOLI Serine acetyltransferase # RefSeq NP_418064 NC_000913.3 # RefSeq WP_001277561 NZ_LN832404.1 # SIMILARITY Belongs to the transferase hexapeptide repeat family. {ECO 0000305}. # SMART SM00971 SATase_N # SUBCELLULAR LOCATION CYSE_ECOLI Cytoplasm. # SUBUNIT CYSE_ECOLI Homohexamer; dimer of a homotrimer (PubMed 10617639). Forms a cysteine synthase complex with 2 copies of CysK (By similarity). {ECO 0000250|UniProtKB P29847, ECO 0000269|PubMed 10617639}. # SUPFAM SSF51161 SSF51161 # TIGRFAMs TIGR01172 cysE # UniPathway UPA00136 UER00199 # eggNOG COG1045 LUCA # eggNOG ENOG4105D7W Bacteria BLAST swissprot:CYSE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CYSE_ECOLI BioCyc ECOL316407:JW3582-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3582-MONOMER BioCyc EcoCyc:SERINE-O-ACETTRAN-MONOMER http://biocyc.org/getid?id=EcoCyc:SERINE-O-ACETTRAN-MONOMER BioCyc MetaCyc:SERINE-O-ACETTRAN-MONOMER http://biocyc.org/getid?id=MetaCyc:SERINE-O-ACETTRAN-MONOMER COG COG1045 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1045 DIP DIP-9377N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9377N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0006-291X(90)90615-T http://dx.doi.org/10.1016/0006-291X(90)90615-T DOI 10.1016/0014-5793(90)80862-D http://dx.doi.org/10.1016/0014-5793(90)80862-D DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.275.1.461 http://dx.doi.org/10.1074/jbc.275.1.461 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1099/00221287-133-3-515 http://dx.doi.org/10.1099/00221287-133-3-515 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.30 http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.30 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M15745 http://www.ebi.ac.uk/ena/data/view/M15745 EMBL M34333 http://www.ebi.ac.uk/ena/data/view/M34333 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.3.1.30 http://enzyme.expasy.org/EC/2.3.1.30 EchoBASE EB0184 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0184 EcoGene EG10187 http://www.ecogene.org/geneInfo.php?eg_id=EG10187 EnsemblBacteria AAC76631 http://www.ensemblgenomes.org/id/AAC76631 EnsemblBacteria AAC76631 http://www.ensemblgenomes.org/id/AAC76631 EnsemblBacteria BAE77685 http://www.ensemblgenomes.org/id/BAE77685 EnsemblBacteria BAE77685 http://www.ensemblgenomes.org/id/BAE77685 EnsemblBacteria BAE77685 http://www.ensemblgenomes.org/id/BAE77685 EnsemblBacteria b3607 http://www.ensemblgenomes.org/id/b3607 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0009333 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009333 GO_function GO:0009001 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009001 GO_process GO:0006535 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006535 GO_process GO:0008652 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008652 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 948126 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948126 HOGENOM HOG000049437 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000049437&db=HOGENOM6 InParanoid P0A9D4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9D4 IntAct P0A9D4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9D4* IntEnz 2.3.1.30 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.30 InterPro IPR001451 http://www.ebi.ac.uk/interpro/entry/IPR001451 InterPro IPR005881 http://www.ebi.ac.uk/interpro/entry/IPR005881 InterPro IPR010493 http://www.ebi.ac.uk/interpro/entry/IPR010493 InterPro IPR011004 http://www.ebi.ac.uk/interpro/entry/IPR011004 InterPro IPR018357 http://www.ebi.ac.uk/interpro/entry/IPR018357 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3582 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3582 KEGG_Gene eco:b3607 http://www.genome.jp/dbget-bin/www_bget?eco:b3607 KEGG_Orthology KO:K00640 http://www.genome.jp/dbget-bin/www_bget?KO:K00640 KEGG_Pathway ko00270 http://www.genome.jp/kegg-bin/show_pathway?ko00270 KEGG_Pathway ko00920 http://www.genome.jp/kegg-bin/show_pathway?ko00920 KEGG_Reaction rn:R00586 http://www.genome.jp/dbget-bin/www_bget?rn:R00586 OMA FHALQSY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FHALQSY PDB 1T3D http://www.ebi.ac.uk/pdbe-srv/view/entry/1T3D PDBsum 1T3D http://www.ebi.ac.uk/pdbsum/1T3D PROSITE PS00101 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00101 PSORT swissprot:CYSE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CYSE_ECOLI PSORT-B swissprot:CYSE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CYSE_ECOLI PSORT2 swissprot:CYSE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CYSE_ECOLI Pfam PF00132 http://pfam.xfam.org/family/PF00132 Pfam PF06426 http://pfam.xfam.org/family/PF06426 Phobius swissprot:CYSE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CYSE_ECOLI PhylomeDB P0A9D4 http://phylomedb.org/?seqid=P0A9D4 ProteinModelPortal P0A9D4 http://www.proteinmodelportal.org/query/uniprot/P0A9D4 PubMed 10617639 http://www.ncbi.nlm.nih.gov/pubmed/10617639 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2108679 http://www.ncbi.nlm.nih.gov/pubmed/2108679 PubMed 2125278 http://www.ncbi.nlm.nih.gov/pubmed/2125278 PubMed 3309158 http://www.ncbi.nlm.nih.gov/pubmed/3309158 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_418064 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418064 RefSeq WP_001277561 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001277561 SMART SM00971 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00971 SMR P0A9D4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9D4 STRING 511145.b3607 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3607&targetmode=cogs STRING COG1045 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1045&targetmode=cogs SUPFAM SSF51161 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51161 TIGRFAMs TIGR01172 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01172 UniProtKB CYSE_ECOLI http://www.uniprot.org/uniprot/CYSE_ECOLI UniProtKB-AC P0A9D4 http://www.uniprot.org/uniprot/P0A9D4 charge swissprot:CYSE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CYSE_ECOLI eggNOG COG1045 http://eggnogapi.embl.de/nog_data/html/tree/COG1045 eggNOG ENOG4105D7W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D7W epestfind swissprot:CYSE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CYSE_ECOLI garnier swissprot:CYSE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CYSE_ECOLI helixturnhelix swissprot:CYSE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CYSE_ECOLI hmoment swissprot:CYSE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CYSE_ECOLI iep swissprot:CYSE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CYSE_ECOLI inforesidue swissprot:CYSE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CYSE_ECOLI octanol swissprot:CYSE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CYSE_ECOLI pepcoil swissprot:CYSE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CYSE_ECOLI pepdigest swissprot:CYSE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CYSE_ECOLI pepinfo swissprot:CYSE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CYSE_ECOLI pepnet swissprot:CYSE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CYSE_ECOLI pepstats swissprot:CYSE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CYSE_ECOLI pepwheel swissprot:CYSE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CYSE_ECOLI pepwindow swissprot:CYSE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CYSE_ECOLI sigcleave swissprot:CYSE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CYSE_ECOLI ## Database ID URL or Descriptions # BioGrid 4259912 501 # DOMAIN PBP2_ECOLI Has a penicillin insensitive transglycosylase domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase domain (cross-linking of the peptide subunits). # DrugBank DB00303 Ertapenem # DrugBank DB00438 Ceftazidime # DrugBank DB00948 Mezlocillin # DrugBank DB01327 Cefazolin # DrugBank DB01328 Cefonicid # DrugBank DB01329 Cefoperazone # DrugBank DB01413 Cefepime # DrugBank DB01415 Ceftibuten # DrugBank DB01598 Imipenem # DrugBank DB06211 Doripenem # EcoGene EG10606 mrdA # FUNCTION PBP2_ECOLI Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. It synthesizes cross- linked peptidoglycan from lipid intermediates. {ECO 0000269|PubMed 1103132}. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoliWiki. # GO_function GO:0008144 drug binding; IDA:EcoCyc. # GO_function GO:0008658 penicillin binding; IMP:EcoliWiki. # GO_function GO:0009002 serine-type D-Ala-D-Ala carboxypeptidase activity; IDA:EcoCyc. # GO_function GO:0071972 peptidoglycan L,D-transpeptidase activity; IDA:EcoliWiki. # GO_process GO:0008360 regulation of cell shape; IMP:EcoliWiki. # GO_process GO:0009252 peptidoglycan biosynthetic process; IMP:EcoCyc. # GO_process GO:0042493 response to drug; IDA:EcoCyc. # GO_process GO:0046677 response to antibiotic; IMP:EcoliWiki. # GO_process GO:0071555 cell wall organization; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 3.40.710.10 -; 1. # IntAct P0AD65 2 # InterPro IPR001460 PCN-bd_Tpept # InterPro IPR005311 PBP_dimer # InterPro IPR012338 Beta-lactam/transpept-like # InterPro IPR017790 Penicillin-binding_protein_2 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko00550 Peptidoglycan biosynthesis # Organism PBP2_ECOLI Escherichia coli (strain K12) # PATHWAY PBP2_ECOLI Cell wall biogenesis; peptidoglycan biosynthesis. # PATRIC 32116453 VBIEscCol129921_0666 # PIR C24995 ZPECP2 # Pfam PF00905 Transpeptidase # Pfam PF03717 PBP_dimer # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PBP2_ECOLI Penicillin-binding protein 2 # RefSeq NP_415168 NC_000913.3 # RefSeq WP_000776191 NZ_LN832404.1 # SIMILARITY Belongs to the transpeptidase family. {ECO 0000305}. # SUBCELLULAR LOCATION PBP2_ECOLI Cell inner membrane {ECO 0000269|PubMed 1103132}; Single-pass membrane protein {ECO 0000269|PubMed 1103132}. # SUPFAM SSF56519 SSF56519 # SUPFAM SSF56601 SSF56601 # TIGRFAMs TIGR03423 pbp2_mrdA # eggNOG COG0768 LUCA # eggNOG ENOG4105CJN Bacteria BLAST swissprot:PBP2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PBP2_ECOLI BioCyc ECOL316407:JW0630-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0630-MONOMER BioCyc EcoCyc:EG10606-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10606-MONOMER BioCyc MetaCyc:EG10606-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10606-MONOMER COG COG0768 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0768 DIP DIP-48190N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48190N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.72.8.2999 http://dx.doi.org/10.1073/pnas.72.8.2999 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1432-1033.1986.tb09961.x http://dx.doi.org/10.1111/j.1432-1033.1986.tb09961.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB00303 http://www.drugbank.ca/drugs/DB00303 DrugBank DB00438 http://www.drugbank.ca/drugs/DB00438 DrugBank DB00948 http://www.drugbank.ca/drugs/DB00948 DrugBank DB01327 http://www.drugbank.ca/drugs/DB01327 DrugBank DB01328 http://www.drugbank.ca/drugs/DB01328 DrugBank DB01329 http://www.drugbank.ca/drugs/DB01329 DrugBank DB01413 http://www.drugbank.ca/drugs/DB01413 DrugBank DB01415 http://www.drugbank.ca/drugs/DB01415 DrugBank DB01598 http://www.drugbank.ca/drugs/DB01598 DrugBank DB06211 http://www.drugbank.ca/drugs/DB06211 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M22857 http://www.ebi.ac.uk/ena/data/view/M22857 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EMBL X04516 http://www.ebi.ac.uk/ena/data/view/X04516 EchoBASE EB0601 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0601 EcoGene EG10606 http://www.ecogene.org/geneInfo.php?eg_id=EG10606 EnsemblBacteria AAC73736 http://www.ensemblgenomes.org/id/AAC73736 EnsemblBacteria AAC73736 http://www.ensemblgenomes.org/id/AAC73736 EnsemblBacteria BAA35282 http://www.ensemblgenomes.org/id/BAA35282 EnsemblBacteria BAA35282 http://www.ensemblgenomes.org/id/BAA35282 EnsemblBacteria BAA35282 http://www.ensemblgenomes.org/id/BAA35282 EnsemblBacteria b0635 http://www.ensemblgenomes.org/id/b0635 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0008144 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008144 GO_function GO:0008658 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008658 GO_function GO:0009002 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009002 GO_function GO:0071972 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071972 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0009252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009252 GO_process GO:0042493 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 3.40.710.10 http://www.cathdb.info/version/latest/superfamily/3.40.710.10 GeneID 945240 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945240 HOGENOM HOG000266120 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000266120&db=HOGENOM6 InParanoid P0AD65 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AD65 IntAct P0AD65 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AD65* InterPro IPR001460 http://www.ebi.ac.uk/interpro/entry/IPR001460 InterPro IPR005311 http://www.ebi.ac.uk/interpro/entry/IPR005311 InterPro IPR012338 http://www.ebi.ac.uk/interpro/entry/IPR012338 InterPro IPR017790 http://www.ebi.ac.uk/interpro/entry/IPR017790 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW0630 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0630 KEGG_Gene eco:b0635 http://www.genome.jp/dbget-bin/www_bget?eco:b0635 KEGG_Orthology KO:K05515 http://www.genome.jp/dbget-bin/www_bget?KO:K05515 KEGG_Pathway ko00550 http://www.genome.jp/kegg-bin/show_pathway?ko00550 OMA WYDGETI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WYDGETI PSORT swissprot:PBP2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PBP2_ECOLI PSORT-B swissprot:PBP2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PBP2_ECOLI PSORT2 swissprot:PBP2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PBP2_ECOLI Pfam PF00905 http://pfam.xfam.org/family/PF00905 Pfam PF03717 http://pfam.xfam.org/family/PF03717 Phobius swissprot:PBP2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PBP2_ECOLI PhylomeDB P0AD65 http://phylomedb.org/?seqid=P0AD65 ProteinModelPortal P0AD65 http://www.proteinmodelportal.org/query/uniprot/P0AD65 PubMed 1103132 http://www.ncbi.nlm.nih.gov/pubmed/1103132 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2644207 http://www.ncbi.nlm.nih.gov/pubmed/2644207 PubMed 3148617 http://www.ncbi.nlm.nih.gov/pubmed/3148617 PubMed 3533535 http://www.ncbi.nlm.nih.gov/pubmed/3533535 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415168 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415168 RefSeq WP_000776191 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000776191 STRING 511145.b0635 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0635&targetmode=cogs STRING COG0768 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0768&targetmode=cogs SUPFAM SSF56519 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56519 SUPFAM SSF56601 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56601 TIGRFAMs TIGR03423 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03423 UniProtKB PBP2_ECOLI http://www.uniprot.org/uniprot/PBP2_ECOLI UniProtKB-AC P0AD65 http://www.uniprot.org/uniprot/P0AD65 charge swissprot:PBP2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PBP2_ECOLI eggNOG COG0768 http://eggnogapi.embl.de/nog_data/html/tree/COG0768 eggNOG ENOG4105CJN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CJN epestfind swissprot:PBP2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PBP2_ECOLI garnier swissprot:PBP2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PBP2_ECOLI helixturnhelix swissprot:PBP2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PBP2_ECOLI hmoment swissprot:PBP2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PBP2_ECOLI iep swissprot:PBP2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PBP2_ECOLI inforesidue swissprot:PBP2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PBP2_ECOLI octanol swissprot:PBP2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PBP2_ECOLI pepcoil swissprot:PBP2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PBP2_ECOLI pepdigest swissprot:PBP2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PBP2_ECOLI pepinfo swissprot:PBP2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PBP2_ECOLI pepnet swissprot:PBP2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PBP2_ECOLI pepstats swissprot:PBP2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PBP2_ECOLI pepwheel swissprot:PBP2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PBP2_ECOLI pepwindow swissprot:PBP2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PBP2_ECOLI sigcleave swissprot:PBP2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PBP2_ECOLI ## Database ID URL or Descriptions # BioGrid 4262251 7 # EcoGene EG14330 ypjJ # InterPro IPR009329 DUF987 # Organism YPJJ_ECOLI Escherichia coli (strain K12) # PATRIC 32120683 VBIEscCol129921_2740 # Pfam PF06174 DUF987 # ProDom PD056719 DUF987 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YPJJ_ECOLI Uncharacterized protein YpjJ # RefSeq YP_588466 NC_000913.3 # SIMILARITY Belongs to the YeeT/YkfH/YpjJ family. {ECO 0000305}. BLAST swissprot:YPJJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YPJJ_ECOLI BioCyc ECOL316407:JW5421-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5421-MONOMER BioCyc EcoCyc:MONOMER0-2686 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2686 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14330 http://www.ecogene.org/geneInfo.php?eg_id=EG14330 EnsemblBacteria ABD18698 http://www.ensemblgenomes.org/id/ABD18698 EnsemblBacteria ABD18698 http://www.ensemblgenomes.org/id/ABD18698 EnsemblBacteria BAE76773 http://www.ensemblgenomes.org/id/BAE76773 EnsemblBacteria BAE76773 http://www.ensemblgenomes.org/id/BAE76773 EnsemblBacteria BAE76773 http://www.ensemblgenomes.org/id/BAE76773 EnsemblBacteria b4548 http://www.ensemblgenomes.org/id/b4548 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1450287 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1450287 HOGENOM HOG000267802 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267802&db=HOGENOM6 InterPro IPR009329 http://www.ebi.ac.uk/interpro/entry/IPR009329 KEGG_Gene ecj:JW5421 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5421 KEGG_Gene eco:b4548 http://www.genome.jp/dbget-bin/www_bget?eco:b4548 OMA YPASRIF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YPASRIF PSORT swissprot:YPJJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YPJJ_ECOLI PSORT-B swissprot:YPJJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YPJJ_ECOLI PSORT2 swissprot:YPJJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YPJJ_ECOLI Pfam PF06174 http://pfam.xfam.org/family/PF06174 Phobius swissprot:YPJJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YPJJ_ECOLI PhylomeDB P58033 http://phylomedb.org/?seqid=P58033 ProteinModelPortal P58033 http://www.proteinmodelportal.org/query/uniprot/P58033 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq YP_588466 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_588466 STRING 511145.b4548 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4548&targetmode=cogs UniProtKB YPJJ_ECOLI http://www.uniprot.org/uniprot/YPJJ_ECOLI UniProtKB-AC P58033 http://www.uniprot.org/uniprot/P58033 charge swissprot:YPJJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YPJJ_ECOLI epestfind swissprot:YPJJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YPJJ_ECOLI garnier swissprot:YPJJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YPJJ_ECOLI helixturnhelix swissprot:YPJJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YPJJ_ECOLI hmoment swissprot:YPJJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YPJJ_ECOLI iep swissprot:YPJJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YPJJ_ECOLI inforesidue swissprot:YPJJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YPJJ_ECOLI octanol swissprot:YPJJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YPJJ_ECOLI pepcoil swissprot:YPJJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YPJJ_ECOLI pepdigest swissprot:YPJJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YPJJ_ECOLI pepinfo swissprot:YPJJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YPJJ_ECOLI pepnet swissprot:YPJJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YPJJ_ECOLI pepstats swissprot:YPJJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YPJJ_ECOLI pepwheel swissprot:YPJJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YPJJ_ECOLI pepwindow swissprot:YPJJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YPJJ_ECOLI sigcleave swissprot:YPJJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YPJJ_ECOLI ## Database ID URL or Descriptions # BRENDA 2.7.1.29 2026 # BioGrid 4260762 3 # DOMAIN DHAL_ECOLI The DhaL subunit corresponds to the C-terminal part of ATP-dependent dihydroxykinases and the DhaK subunit corresponds to the N-terminal part. # EcoGene EG13900 dhaL # FUNCTION DHAL_ECOLI ADP-binding subunit of the dihydroxyacetone kinase, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaL-ADP receives a phosphoryl group from DhaM and transmits it to dihydroxyacetone. DhaL-ADP acts also as a coactivator by binding to the sensor domain of DhaR. DhaL-ATP is inactive. {ECO 0000269|PubMed 11350937}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0004371 glycerone kinase activity; IEA:InterPro. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0043531 ADP binding; IDA:EcoCyc. # GO_process GO:0019563 glycerol catabolic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # InterPro IPR004007 DhaL_dom # InterPro IPR012737 DhaK_L_YcgS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00561 Glycerolipid metabolism # MISCELLANEOUS DHAL_ECOLI Complexation with ADP increases the thermal unfolding temperature from 40 to 65 degrees Celsius. The tightly bound ADP participates in a double displacement phosphoryl transfer reaction and thus plays the same role as histidines, cysteines and aspartic acids in other phosphoprotein intermediates. # MISCELLANEOUS DHAL_ECOLI Unlike the carbohydrate-specific transporters of the PTS, the complex DhaKML has no transport activity. # Organism DHAL_ECOLI Escherichia coli (strain K12) # PATHWAY DHAL_ECOLI Polyol metabolism; glycerol degradation. # PATRIC 32117648 VBIEscCol129921_1246 # PDB 2BTD X-ray; 2.60 A; A=1-210 # PDB 3PNL X-ray; 2.20 A; B=2-210 # PDB 4LRZ X-ray; 2.32 A; A/B/C/D=2-210 # PIR D64866 D64866 # PROSITE PS51480 DHAL # Pfam PF02734 Dak2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DHAL_ECOLI PEP-dependent dihydroxyacetone kinase, ADP-binding subunit DhaL # RefSeq NP_415717 NC_000913.3 # RefSeq WP_000059411 NZ_LN832404.1 # SIMILARITY Contains 1 DhaL domain. {ECO:0000255|PROSITE- ProRule PRU00813}. # SMART SM01120 Dak2 # SUBUNIT The dihydroxyacetone kinase complex is composed of a homodimer of DhaM, a homodimer of DhaK and the subunit DhaL. {ECO:0000269|PubMed 16647083}. # SUPFAM SSF101473 SSF101473 # TIGRFAMs TIGR02365 dha_L_ycgS # eggNOG COG2376 LUCA # eggNOG ENOG4108UTZ Bacteria BLAST swissprot:DHAL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DHAL_ECOLI BioCyc ECOL316407:JW5186-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5186-MONOMER BioCyc EcoCyc:MONOMER0-1261 http://biocyc.org/getid?id=EcoCyc:MONOMER0-1261 BioCyc MetaCyc:MONOMER0-1261 http://biocyc.org/getid?id=MetaCyc:MONOMER0-1261 COG COG2376 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2376 DIP DIP-11562N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11562N DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1016/j.jmb.2006.03.057 http://dx.doi.org/10.1016/j.jmb.2006.03.057 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M500279200 http://dx.doi.org/10.1074/jbc.M500279200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/emboj/20.10.2480 http://dx.doi.org/10.1093/emboj/20.10.2480 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.-.- http://www.genome.jp/dbget-bin/www_bget?EC:2.7.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.-.- http://enzyme.expasy.org/EC/2.7.-.- EchoBASE EB3659 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3659 EcoGene EG13900 http://www.ecogene.org/geneInfo.php?eg_id=EG13900 EnsemblBacteria AAC74283 http://www.ensemblgenomes.org/id/AAC74283 EnsemblBacteria AAC74283 http://www.ensemblgenomes.org/id/AAC74283 EnsemblBacteria BAA36056 http://www.ensemblgenomes.org/id/BAA36056 EnsemblBacteria BAA36056 http://www.ensemblgenomes.org/id/BAA36056 EnsemblBacteria BAA36056 http://www.ensemblgenomes.org/id/BAA36056 EnsemblBacteria b1199 http://www.ensemblgenomes.org/id/b1199 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0004371 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004371 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0043531 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043531 GO_process GO:0019563 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019563 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 945748 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945748 HOGENOM HOG000226525 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000226525&db=HOGENOM6 InParanoid P76014 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76014 IntEnz 2.7 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7 InterPro IPR004007 http://www.ebi.ac.uk/interpro/entry/IPR004007 InterPro IPR012737 http://www.ebi.ac.uk/interpro/entry/IPR012737 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5186 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5186 KEGG_Gene eco:b1199 http://www.genome.jp/dbget-bin/www_bget?eco:b1199 KEGG_Orthology KO:K05879 http://www.genome.jp/dbget-bin/www_bget?KO:K05879 KEGG_Pathway ko00561 http://www.genome.jp/kegg-bin/show_pathway?ko00561 KEGG_Reaction rn:R01011 http://www.genome.jp/dbget-bin/www_bget?rn:R01011 OMA GENVDRG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GENVDRG PDB 2BTD http://www.ebi.ac.uk/pdbe-srv/view/entry/2BTD PDB 3PNL http://www.ebi.ac.uk/pdbe-srv/view/entry/3PNL PDB 4LRZ http://www.ebi.ac.uk/pdbe-srv/view/entry/4LRZ PDBsum 2BTD http://www.ebi.ac.uk/pdbsum/2BTD PDBsum 3PNL http://www.ebi.ac.uk/pdbsum/3PNL PDBsum 4LRZ http://www.ebi.ac.uk/pdbsum/4LRZ PROSITE PS51480 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51480 PSORT swissprot:DHAL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DHAL_ECOLI PSORT-B swissprot:DHAL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DHAL_ECOLI PSORT2 swissprot:DHAL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DHAL_ECOLI Pfam PF02734 http://pfam.xfam.org/family/PF02734 Phobius swissprot:DHAL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DHAL_ECOLI PhylomeDB P76014 http://phylomedb.org/?seqid=P76014 ProteinModelPortal P76014 http://www.proteinmodelportal.org/query/uniprot/P76014 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 11350937 http://www.ncbi.nlm.nih.gov/pubmed/11350937 PubMed 15753087 http://www.ncbi.nlm.nih.gov/pubmed/15753087 PubMed 16647083 http://www.ncbi.nlm.nih.gov/pubmed/16647083 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415717 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415717 RefSeq WP_000059411 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000059411 SMART SM01120 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01120 SMR P76014 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76014 STRING 511145.b1199 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1199&targetmode=cogs STRING COG2376 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2376&targetmode=cogs SUPFAM SSF101473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF101473 TIGRFAMs TIGR02365 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02365 UniProtKB DHAL_ECOLI http://www.uniprot.org/uniprot/DHAL_ECOLI UniProtKB-AC P76014 http://www.uniprot.org/uniprot/P76014 charge swissprot:DHAL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DHAL_ECOLI eggNOG COG2376 http://eggnogapi.embl.de/nog_data/html/tree/COG2376 eggNOG ENOG4108UTZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UTZ epestfind swissprot:DHAL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DHAL_ECOLI garnier swissprot:DHAL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DHAL_ECOLI helixturnhelix swissprot:DHAL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DHAL_ECOLI hmoment swissprot:DHAL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DHAL_ECOLI iep swissprot:DHAL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DHAL_ECOLI inforesidue swissprot:DHAL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DHAL_ECOLI octanol swissprot:DHAL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DHAL_ECOLI pepcoil swissprot:DHAL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DHAL_ECOLI pepdigest swissprot:DHAL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DHAL_ECOLI pepinfo swissprot:DHAL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DHAL_ECOLI pepnet swissprot:DHAL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DHAL_ECOLI pepstats swissprot:DHAL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DHAL_ECOLI pepwheel swissprot:DHAL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DHAL_ECOLI pepwindow swissprot:DHAL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DHAL_ECOLI sigcleave swissprot:DHAL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DHAL_ECOLI ## Database ID URL or Descriptions # BRENDA 3.1.26.12 2026 # BioGrid 4261023 189 # CATALYTIC ACTIVITY RNE_ECOLI Endonucleolytic cleavage of single-stranded RNA in A- and U-rich regions. {ECO 0000255|HAMAP-Rule MF_00970, ECO 0000269|PubMed 15779893, ECO 0000269|PubMed 16237448, ECO 0000269|PubMed 19889093}. # COFACTOR RNE_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 16237448}; Note=Binds 1 Mg(2+) ion per subunit. {ECO 0000269|PubMed 16237448}; # COFACTOR RNE_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 15779893, ECO 0000269|PubMed 16237448, ECO 0000269|PubMed 18682225}; Note=Binds 2 Zn(2+) ions per homotetramer. Zinc ions are bound between subunits and are essential for homotetramerization and catalytic activity, but not for RNA binding. In the absence of zinc, the protein dissociates into inactive dimers. {ECO 0000269|PubMed 15779893}; # DOMAIN RNE_ECOLI The N-terminal S1 motif binds RNA, and can also bind single-stranded DNA (in vitro). The C-terminal region interacts with the other degradosomal components. {ECO 0000269|PubMed 15312761, ECO 0000269|PubMed 9732274}. # ENZYME REGULATION Binding to the membrane stabilizes protein structure and increases affinity for the substrate. {ECO:0000269|PubMed 22509045}. # EcoGene EG10859 rne # FUNCTION RNE_ECOLI Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Can also process other RNA species, such as RNAI, a molecule that controls the replication of ColE1 plasmid, and the cell division inhibitor DicF-RNA. It initiates the decay of RNAs by cutting them internally near their 5'-end. It is able to remove poly(A) tails by an endonucleolytic process. {ECO 0000255|HAMAP- Rule MF_00970, ECO 0000269|PubMed 10329633, ECO 0000269|PubMed 11328869, ECO 0000269|PubMed 11871663, ECO 0000269|PubMed 16237448, ECO 0000269|PubMed 1691299, ECO 0000269|PubMed 1708438, ECO 0000269|PubMed 19889093, ECO 0000269|PubMed 6339234, ECO 0000269|PubMed 9732274}. # GO_component GO:0005737 cytoplasm; IDA:EcoCyc. # GO_component GO:0009898 cytoplasmic side of plasma membrane; IEA:UniProtKB-HAMAP. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0003723 RNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0004521 endoribonuclease activity; IEA:UniProtKB-HAMAP. # GO_function GO:0004540 ribonuclease activity; IBA:GO_Central. # GO_function GO:0008270 zinc ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008995 ribonuclease E activity; IEA:InterPro. # GO_process GO:0000967 rRNA 5'-end processing; IMP:EcoCyc. # GO_process GO:0006401 RNA catabolic process; IDA:EcoCyc. # GO_process GO:0006402 mRNA catabolic process; IEA:UniProtKB-HAMAP. # GO_process GO:0008033 tRNA processing; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0004518 nuclease activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # HAMAP MF_00970 RNase_E # INTERACTION RNE_ECOLI P0A6Y8 dnaK; NbExp=9; IntAct=EBI-549958, EBI-542092; P0A6P9 eno; NbExp=15; IntAct=EBI-549958, EBI-368855; P05055 pnp; NbExp=11; IntAct=EBI-549958, EBI-548080; P0A8J8 rhlB; NbExp=16; IntAct=EBI-549958, EBI-555806; # IntAct P21513 61 # InterPro IPR003029 S1_domain # InterPro IPR004659 RNase_E/G # InterPro IPR012340 NA-bd_OB-fold # InterPro IPR019307 RNA-bd_AU-1/RNase_E/G # InterPro IPR021968 PNPase_C # InterPro IPR022967 S1_dom # InterPro IPR028878 RNase_E # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # KEGG_Pathway ko03018 RNA degradation # Organism RNE_ECOLI Escherichia coli (strain K12) # PATRIC 32117409 VBIEscCol129921_1127 # PDB 1SLJ NMR; -; A=35-125 # PDB 1SMX X-ray; 1.80 A; A/B=35-125 # PDB 1SN8 X-ray; 2.00 A; A/B=35-125 # PDB 2BX2 X-ray; 2.85 A; L=1-510 # PDB 2C0B X-ray; 3.18 A; L=1-510 # PDB 2C4R X-ray; 3.60 A; L=1-510 # PDB 2FYM X-ray; 1.60 A; B/E=833-850 # PDB 2VMK X-ray; 3.30 A; A/B/C/D=1-515 # PDB 2VRT X-ray; 3.50 A; A/B/C/D=1-509 # PDB 3GCM X-ray; 2.50 A; D/E/F=1021-1061 # PDB 3GME X-ray; 2.40 A; D=1021-1061 # PDB 3H1C X-ray; 3.57 A; D/E/F/H/J/L/N/P/S/U/W/Y=1021-1061 # PDB 3H8A X-ray; 1.90 A; E/F=823-850 # PIR A64852 S27311 # PROSITE PS50126 S1 # Pfam PF00575 S1 # Pfam PF10150 RNase_E_G # Pfam PF12111 PNPase_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Ribonuclease E {ECO:0000255|HAMAP-Rule MF_00970} # RefSeq NP_415602 NC_000913.3 # RefSeq WP_000827360 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA23443.1; Type=Frameshift; Positions=796; Evidence={ECO:0000305}; Sequence=CAA38206.1; Type=Frameshift; Positions=Several; Evidence={ECO 0000305}; Sequence=CAA47818.1; Type=Frameshift; Positions=1003; Evidence={ECO:0000305}; # SIMILARITY Belongs to the RNase E/G family. RNase E subfamily. {ECO:0000255|HAMAP-Rule MF_00970}. # SIMILARITY Contains 1 S1 motif domain. {ECO:0000255|HAMAP- Rule MF_00970}. # SMART SM00316 S1 # SUBCELLULAR LOCATION RNE_ECOLI Cytoplasm {ECO 0000269|PubMed 11134527}. Cell inner membrane {ECO 0000269|PubMed 11134527, ECO 0000269|PubMed 22509045}; Peripheral membrane protein {ECO 0000269|PubMed 11134527, ECO 0000269|PubMed 22509045}; Cytoplasmic side {ECO 0000269|PubMed 11134527, ECO 0000269|PubMed 22509045}. Note=Associated with the cytoplasmic membrane via the N- and C-terminal regions. {ECO 0000269|PubMed 11134527, ECO 0000269|PubMed 22509045}. # SUBUNIT RNE_ECOLI Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation. Within the RNA degradosome, Rnase E assembles into a homotetramer formed by a dimer of dimers. Tetramerization is essential for catalytic activity, but not for RNA-binding. Interacts with RhlB, PNPase (pnp) and enolase (eno). Interacts with DeaD at reduced temperature. {ECO 0000255|HAMAP-Rule MF_00970, ECO 0000269|PubMed 11134527, ECO 0000269|PubMed 15312761, ECO 0000269|PubMed 15554978, ECO 0000269|PubMed 15779893, ECO 0000269|PubMed 16237448, ECO 0000269|PubMed 16516921, ECO 0000269|PubMed 18337249, ECO 0000269|PubMed 18682225, ECO 0000269|PubMed 19327365, ECO 0000269|PubMed 20823555, ECO 0000269|PubMed 9732274}. # SUPFAM SSF50249 SSF50249 # TIGRFAMs TIGR00757 RNaseEG # eggNOG COG1530 LUCA # eggNOG ENOG4107QQB Bacteria BLAST swissprot:RNE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RNE_ECOLI BioCyc ECOL316407:JW1071-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1071-MONOMER BioCyc EcoCyc:EG10859-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10859-MONOMER BioCyc MetaCyc:EG10859-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10859-MONOMER COG COG1530 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1530 DIP DIP-10727N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10727N DOI 10.1016/0022-2836(90)90325-G http://dx.doi.org/10.1016/0022-2836(90)90325-G DOI 10.1016/0022-2836(92)90489-7 http://dx.doi.org/10.1016/0022-2836(92)90489-7 DOI 10.1016/j.jmb.2004.05.061 http://dx.doi.org/10.1016/j.jmb.2004.05.061 DOI 10.1016/j.jmb.2006.02.012 http://dx.doi.org/10.1016/j.jmb.2006.02.012 DOI 10.1016/j.jmb.2009.03.051 http://dx.doi.org/10.1016/j.jmb.2009.03.051 DOI 10.1016/j.str.2008.04.017 http://dx.doi.org/10.1016/j.str.2008.04.017 DOI 10.1017/S1355838202014929 http://dx.doi.org/10.1017/S1355838202014929 DOI 10.1021/bi0478244 http://dx.doi.org/10.1021/bi0478244 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature04084 http://dx.doi.org/10.1038/nature04084 DOI 10.1073/pnas.1120181109 http://dx.doi.org/10.1073/pnas.1120181109 DOI 10.1073/pnas.90.19.9006 http://dx.doi.org/10.1073/pnas.90.19.9006 DOI 10.1073/pnas.98.1.63 http://dx.doi.org/10.1073/pnas.98.1.63 DOI 10.1074/jbc.M709118200 http://dx.doi.org/10.1074/jbc.M709118200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/emboj/18.10.2878 http://dx.doi.org/10.1093/emboj/18.10.2878 DOI 10.1093/nar/19.1.125 http://dx.doi.org/10.1093/nar/19.1.125 DOI 10.1093/nar/29.9.1864 http://dx.doi.org/10.1093/nar/29.9.1864 DOI 10.1101/gad.12.17.2770 http://dx.doi.org/10.1101/gad.12.17.2770 DOI 10.1107/S0907444910030015 http://dx.doi.org/10.1107/S0907444910030015 DOI 10.1111/j.1365-2958.1990.tb00574.x http://dx.doi.org/10.1111/j.1365-2958.1990.tb00574.x DOI 10.1111/j.1365-2958.2004.04360.x http://dx.doi.org/10.1111/j.1365-2958.2004.04360.x DOI 10.1111/j.1365-2958.2009.06935.x http://dx.doi.org/10.1111/j.1365-2958.2009.06935.x DOI 10.1111/j.1432-1033.1983.tb07238.x http://dx.doi.org/10.1111/j.1432-1033.1983.tb07238.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DisProt DP00207 http://www.disprot.org/protein.php?id=DP00207 EC_number EC:3.1.26.12 {ECO:0000255|HAMAP-Rule:MF_00970} http://www.genome.jp/dbget-bin/www_bget?EC:3.1.26.12 {ECO:0000255|HAMAP-Rule:MF_00970} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L23942 http://www.ebi.ac.uk/ena/data/view/L23942 EMBL M62747 http://www.ebi.ac.uk/ena/data/view/M62747 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X54309 http://www.ebi.ac.uk/ena/data/view/X54309 EMBL X67470 http://www.ebi.ac.uk/ena/data/view/X67470 ENZYME 3.1.26.12 {ECO:0000255|HAMAP-Rule:MF_00970} http://enzyme.expasy.org/EC/3.1.26.12 {ECO:0000255|HAMAP-Rule:MF_00970} EchoBASE EB0852 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0852 EcoGene EG10859 http://www.ecogene.org/geneInfo.php?eg_id=EG10859 EnsemblBacteria AAC74168 http://www.ensemblgenomes.org/id/AAC74168 EnsemblBacteria AAC74168 http://www.ensemblgenomes.org/id/AAC74168 EnsemblBacteria BAA35893 http://www.ensemblgenomes.org/id/BAA35893 EnsemblBacteria BAA35893 http://www.ensemblgenomes.org/id/BAA35893 EnsemblBacteria BAA35893 http://www.ensemblgenomes.org/id/BAA35893 EnsemblBacteria b1084 http://www.ensemblgenomes.org/id/b1084 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0009898 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009898 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0004521 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004521 GO_function GO:0004540 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004540 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0008995 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008995 GO_process GO:0000967 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000967 GO_process GO:0006401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006401 GO_process GO:0006402 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006402 GO_process GO:0008033 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008033 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 GeneID 945641 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945641 HAMAP MF_00970 http://hamap.expasy.org/unirule/MF_00970 HOGENOM HOG000258027 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000258027&db=HOGENOM6 InParanoid P21513 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P21513 IntAct P21513 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P21513* IntEnz 3.1.26.12 {ECO:0000255|HAMAP-Rule:MF_00970} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.26.12 {ECO:0000255|HAMAP-Rule:MF_00970} InterPro IPR003029 http://www.ebi.ac.uk/interpro/entry/IPR003029 InterPro IPR004659 http://www.ebi.ac.uk/interpro/entry/IPR004659 InterPro IPR012340 http://www.ebi.ac.uk/interpro/entry/IPR012340 InterPro IPR019307 http://www.ebi.ac.uk/interpro/entry/IPR019307 InterPro IPR021968 http://www.ebi.ac.uk/interpro/entry/IPR021968 InterPro IPR022967 http://www.ebi.ac.uk/interpro/entry/IPR022967 InterPro IPR028878 http://www.ebi.ac.uk/interpro/entry/IPR028878 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW1071 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1071 KEGG_Gene eco:b1084 http://www.genome.jp/dbget-bin/www_bget?eco:b1084 KEGG_Orthology KO:K08300 http://www.genome.jp/dbget-bin/www_bget?KO:K08300 KEGG_Pathway ko03018 http://www.genome.jp/kegg-bin/show_pathway?ko03018 MINT MINT-1220086 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1220086 OMA EYFPSNY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EYFPSNY PDB 1SLJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1SLJ PDB 1SMX http://www.ebi.ac.uk/pdbe-srv/view/entry/1SMX PDB 1SN8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1SN8 PDB 2BX2 http://www.ebi.ac.uk/pdbe-srv/view/entry/2BX2 PDB 2C0B http://www.ebi.ac.uk/pdbe-srv/view/entry/2C0B PDB 2C4R http://www.ebi.ac.uk/pdbe-srv/view/entry/2C4R PDB 2FYM http://www.ebi.ac.uk/pdbe-srv/view/entry/2FYM PDB 2VMK http://www.ebi.ac.uk/pdbe-srv/view/entry/2VMK PDB 2VRT http://www.ebi.ac.uk/pdbe-srv/view/entry/2VRT PDB 3GCM http://www.ebi.ac.uk/pdbe-srv/view/entry/3GCM PDB 3GME http://www.ebi.ac.uk/pdbe-srv/view/entry/3GME PDB 3H1C http://www.ebi.ac.uk/pdbe-srv/view/entry/3H1C PDB 3H8A http://www.ebi.ac.uk/pdbe-srv/view/entry/3H8A PDBsum 1SLJ http://www.ebi.ac.uk/pdbsum/1SLJ PDBsum 1SMX http://www.ebi.ac.uk/pdbsum/1SMX PDBsum 1SN8 http://www.ebi.ac.uk/pdbsum/1SN8 PDBsum 2BX2 http://www.ebi.ac.uk/pdbsum/2BX2 PDBsum 2C0B http://www.ebi.ac.uk/pdbsum/2C0B PDBsum 2C4R http://www.ebi.ac.uk/pdbsum/2C4R PDBsum 2FYM http://www.ebi.ac.uk/pdbsum/2FYM PDBsum 2VMK http://www.ebi.ac.uk/pdbsum/2VMK PDBsum 2VRT http://www.ebi.ac.uk/pdbsum/2VRT PDBsum 3GCM http://www.ebi.ac.uk/pdbsum/3GCM PDBsum 3GME http://www.ebi.ac.uk/pdbsum/3GME PDBsum 3H1C http://www.ebi.ac.uk/pdbsum/3H1C PDBsum 3H8A http://www.ebi.ac.uk/pdbsum/3H8A PROSITE PS50126 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50126 PSORT swissprot:RNE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RNE_ECOLI PSORT-B swissprot:RNE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RNE_ECOLI PSORT2 swissprot:RNE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RNE_ECOLI Pfam PF00575 http://pfam.xfam.org/family/PF00575 Pfam PF10150 http://pfam.xfam.org/family/PF10150 Pfam PF12111 http://pfam.xfam.org/family/PF12111 Phobius swissprot:RNE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RNE_ECOLI ProteinModelPortal P21513 http://www.proteinmodelportal.org/query/uniprot/P21513 PubMed 10329633 http://www.ncbi.nlm.nih.gov/pubmed/10329633 PubMed 11134527 http://www.ncbi.nlm.nih.gov/pubmed/11134527 PubMed 11328869 http://www.ncbi.nlm.nih.gov/pubmed/11328869 PubMed 11871663 http://www.ncbi.nlm.nih.gov/pubmed/11871663 PubMed 1447789 http://www.ncbi.nlm.nih.gov/pubmed/1447789 PubMed 15312761 http://www.ncbi.nlm.nih.gov/pubmed/15312761 PubMed 15554978 http://www.ncbi.nlm.nih.gov/pubmed/15554978 PubMed 15779893 http://www.ncbi.nlm.nih.gov/pubmed/15779893 PubMed 16237448 http://www.ncbi.nlm.nih.gov/pubmed/16237448 PubMed 16516921 http://www.ncbi.nlm.nih.gov/pubmed/16516921 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1691299 http://www.ncbi.nlm.nih.gov/pubmed/1691299 PubMed 1704367 http://www.ncbi.nlm.nih.gov/pubmed/1704367 PubMed 1708438 http://www.ncbi.nlm.nih.gov/pubmed/1708438 PubMed 18337249 http://www.ncbi.nlm.nih.gov/pubmed/18337249 PubMed 18682225 http://www.ncbi.nlm.nih.gov/pubmed/18682225 PubMed 19327365 http://www.ncbi.nlm.nih.gov/pubmed/19327365 PubMed 19889093 http://www.ncbi.nlm.nih.gov/pubmed/19889093 PubMed 2011493 http://www.ncbi.nlm.nih.gov/pubmed/2011493 PubMed 20823555 http://www.ncbi.nlm.nih.gov/pubmed/20823555 PubMed 22509045 http://www.ncbi.nlm.nih.gov/pubmed/22509045 PubMed 6339234 http://www.ncbi.nlm.nih.gov/pubmed/6339234 PubMed 8415644 http://www.ncbi.nlm.nih.gov/pubmed/8415644 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9732274 http://www.ncbi.nlm.nih.gov/pubmed/9732274 RefSeq NP_415602 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415602 RefSeq WP_000827360 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000827360 SMART SM00316 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00316 SMR P21513 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P21513 STRING 511145.b1084 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1084&targetmode=cogs STRING COG1530 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1530&targetmode=cogs SUPFAM SSF50249 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50249 TIGRFAMs TIGR00757 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00757 UniProtKB RNE_ECOLI http://www.uniprot.org/uniprot/RNE_ECOLI UniProtKB-AC P21513 http://www.uniprot.org/uniprot/P21513 charge swissprot:RNE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RNE_ECOLI eggNOG COG1530 http://eggnogapi.embl.de/nog_data/html/tree/COG1530 eggNOG ENOG4107QQB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QQB epestfind swissprot:RNE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RNE_ECOLI garnier swissprot:RNE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RNE_ECOLI helixturnhelix swissprot:RNE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RNE_ECOLI hmoment swissprot:RNE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RNE_ECOLI iep swissprot:RNE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RNE_ECOLI inforesidue swissprot:RNE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RNE_ECOLI octanol swissprot:RNE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RNE_ECOLI pepcoil swissprot:RNE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RNE_ECOLI pepdigest swissprot:RNE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RNE_ECOLI pepinfo swissprot:RNE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RNE_ECOLI pepnet swissprot:RNE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RNE_ECOLI pepstats swissprot:RNE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RNE_ECOLI pepwheel swissprot:RNE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RNE_ECOLI pepwindow swissprot:RNE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RNE_ECOLI sigcleave swissprot:RNE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RNE_ECOLI ## Database ID URL or Descriptions # BioGrid 4260028 4 # EcoGene EG12966 pqiB # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # INDUCTION PQIB_ECOLI By paraquat. # IntAct P43671 4 # InterPro IPR003399 Mce/MlaD # Organism PQIB_ECOLI Escherichia coli (strain K12) # PATRIC 32117121 VBIEscCol129921_0985 # PIR F64835 F64835 # Pfam PF02470 MlaD; 3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PQIB_ECOLI Paraquat-inducible protein B # RefSeq NP_415471 NC_000913.3 # RefSeq WP_000445533 NZ_LN832404.1 # SIMILARITY Belongs to the PqiB family. {ECO 0000305}. # SUBCELLULAR LOCATION PQIB_ECOLI Cell membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. # eggNOG COG3008 LUCA # eggNOG ENOG4105DY2 Bacteria BLAST swissprot:PQIB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PQIB_ECOLI BioCyc ECOL316407:JW0934-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0934-MONOMER BioCyc EcoCyc:G6491-MONOMER http://biocyc.org/getid?id=EcoCyc:G6491-MONOMER COG COG3008 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3008 DIP DIP-10555N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10555N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X81561 http://www.ebi.ac.uk/ena/data/view/X81561 EchoBASE EB2795 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2795 EcoGene EG12966 http://www.ecogene.org/geneInfo.php?eg_id=EG12966 EnsemblBacteria AAC74037 http://www.ensemblgenomes.org/id/AAC74037 EnsemblBacteria AAC74037 http://www.ensemblgenomes.org/id/AAC74037 EnsemblBacteria BAA35709 http://www.ensemblgenomes.org/id/BAA35709 EnsemblBacteria BAA35709 http://www.ensemblgenomes.org/id/BAA35709 EnsemblBacteria BAA35709 http://www.ensemblgenomes.org/id/BAA35709 EnsemblBacteria b0951 http://www.ensemblgenomes.org/id/b0951 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 945653 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945653 HOGENOM HOG000256423 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000256423&db=HOGENOM6 InParanoid P43671 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P43671 IntAct P43671 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P43671* InterPro IPR003399 http://www.ebi.ac.uk/interpro/entry/IPR003399 KEGG_Gene ecj:JW0934 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0934 KEGG_Gene eco:b0951 http://www.genome.jp/dbget-bin/www_bget?eco:b0951 KEGG_Orthology KO:K06192 http://www.genome.jp/dbget-bin/www_bget?KO:K06192 MINT MINT-1310231 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1310231 OMA HHVEIKA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HHVEIKA PSORT swissprot:PQIB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PQIB_ECOLI PSORT-B swissprot:PQIB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PQIB_ECOLI PSORT2 swissprot:PQIB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PQIB_ECOLI Pfam PF02470 http://pfam.xfam.org/family/PF02470 Phobius swissprot:PQIB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PQIB_ECOLI PhylomeDB P43671 http://phylomedb.org/?seqid=P43671 ProteinModelPortal P43671 http://www.proteinmodelportal.org/query/uniprot/P43671 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7751275 http://www.ncbi.nlm.nih.gov/pubmed/7751275 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415471 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415471 RefSeq WP_000445533 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000445533 STRING 511145.b0951 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0951&targetmode=cogs STRING COG3008 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3008&targetmode=cogs UniProtKB PQIB_ECOLI http://www.uniprot.org/uniprot/PQIB_ECOLI UniProtKB-AC P43671 http://www.uniprot.org/uniprot/P43671 charge swissprot:PQIB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PQIB_ECOLI eggNOG COG3008 http://eggnogapi.embl.de/nog_data/html/tree/COG3008 eggNOG ENOG4105DY2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DY2 epestfind swissprot:PQIB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PQIB_ECOLI garnier swissprot:PQIB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PQIB_ECOLI helixturnhelix swissprot:PQIB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PQIB_ECOLI hmoment swissprot:PQIB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PQIB_ECOLI iep swissprot:PQIB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PQIB_ECOLI inforesidue swissprot:PQIB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PQIB_ECOLI octanol swissprot:PQIB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PQIB_ECOLI pepcoil swissprot:PQIB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PQIB_ECOLI pepdigest swissprot:PQIB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PQIB_ECOLI pepinfo swissprot:PQIB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PQIB_ECOLI pepnet swissprot:PQIB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PQIB_ECOLI pepstats swissprot:PQIB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PQIB_ECOLI pepwheel swissprot:PQIB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PQIB_ECOLI pepwindow swissprot:PQIB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PQIB_ECOLI sigcleave swissprot:PQIB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PQIB_ECOLI ## Database ID URL or Descriptions # AltName MLTA_ECOLI Mlt38 # AltName MLTA_ECOLI Murein hydrolase A # BIOPHYSICOCHEMICAL PROPERTIES pH dependence: Optimum pH is 4.0-4.5.; Temperature dependence Loses rapidly its activity at temperatures above 30 degrees Celsius.; # BioGrid 4261126 187 # CATALYTIC ACTIVITY MLTA_ECOLI Exolytic cleavage of the (1->4)-beta- glycosidic linkage between N-acetylmuramic acid (MurNAc) and N- acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue. # CAZy GH102 Glycoside Hydrolase Family 102 # EcoGene EG13085 mltA # FUNCTION MLTA_ECOLI Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoliWiki. # GO_component GO:0009279 cell outer membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IDA:EcoCyc. # GO_function GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds; IDA:EcoCyc. # GO_function GO:0008933 lytic transglycosylase activity; IDA:EcoliWiki. # GO_function GO:0052762 gellan lyase activity; IEA:UniProtKB-EC. # GO_function GO:0052764 exo-oligoalginate lyase activity; IEA:UniProtKB-EC. # GO_process GO:0009252 peptidoglycan biosynthetic process; IDA:EcoCyc. # GO_process GO:0009254 peptidoglycan turnover; IEA:InterPro. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 2.40.40.10 -; 2. # InterPro IPR005300 Lytic_transglycosylase_MltA # InterPro IPR009009 RlpA-like_DPBB # InterPro IPR010611 3D_dom # KEGG_Brite ko01000 Enzymes # Organism MLTA_ECOLI Escherichia coli (strain K12) # PATRIC 32121044 VBIEscCol129921_2914 # PDB 2AE0 X-ray; 2.00 A; X=22-365 # PDB 2GAE X-ray; 2.50 A; A=22-365 # PDB 2PI8 X-ray; 2.25 A; A/B/C/D=22-365 # PDB 2PIC X-ray; 2.25 A; A=22-365 # PDB 2PJJ X-ray; 2.46 A; A=22-365 # PIR A65064 A65064 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF03562 MltA # Pfam PF06725 3D # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MLTA_ECOLI Membrane-bound lytic murein transglycosylase A # RefSeq NP_417293 NC_000913.3 # RefSeq WP_000678646 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40463.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SMART SM00925 MltA # SUBCELLULAR LOCATION MLTA_ECOLI Cell outer membrane; Lipid-anchor. # SUBUNIT MLTA_ECOLI Forms a trimeric complex with MrcB/PonB and MipA in vitro. # SUPFAM SSF50685 SSF50685 # eggNOG COG2821 LUCA # eggNOG ENOG4105CA3 Bacteria BLAST swissprot:MLTA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MLTA_ECOLI BioCyc ECOL316407:JW2784-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2784-MONOMER BioCyc EcoCyc:G7457-MONOMER http://biocyc.org/getid?id=EcoCyc:G7457-MONOMER BioCyc MetaCyc:G7457-MONOMER http://biocyc.org/getid?id=MetaCyc:G7457-MONOMER COG COG2821 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2821 DIP DIP-51238N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-51238N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.274.10.6726 http://dx.doi.org/10.1074/jbc.274.10.6726 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.2.n1 http://www.genome.jp/dbget-bin/www_bget?EC:4.2.2.n1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 EMBL U32224 http://www.ebi.ac.uk/ena/data/view/U32224 ENZYME 4.2.2.n1 http://enzyme.expasy.org/EC/4.2.2.n1 EchoBASE EB2894 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2894 EcoGene EG13085 http://www.ecogene.org/geneInfo.php?eg_id=EG13085 EnsemblBacteria AAC75855 http://www.ensemblgenomes.org/id/AAC75855 EnsemblBacteria AAC75855 http://www.ensemblgenomes.org/id/AAC75855 EnsemblBacteria BAE76885 http://www.ensemblgenomes.org/id/BAE76885 EnsemblBacteria BAE76885 http://www.ensemblgenomes.org/id/BAE76885 EnsemblBacteria BAE76885 http://www.ensemblgenomes.org/id/BAE76885 EnsemblBacteria b2813 http://www.ensemblgenomes.org/id/b2813 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0004553 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004553 GO_function GO:0008933 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008933 GO_function GO:0052762 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052762 GO_function GO:0052764 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052764 GO_process GO:0009252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009252 GO_process GO:0009254 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009254 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 2.40.40.10 http://www.cathdb.info/version/latest/superfamily/2.40.40.10 GeneID 944964 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944964 HOGENOM HOG000278098 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278098&db=HOGENOM6 InParanoid P0A935 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A935 IntAct P0A935 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A935* IntEnz 4.2.2.n1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.2.n1 InterPro IPR005300 http://www.ebi.ac.uk/interpro/entry/IPR005300 InterPro IPR009009 http://www.ebi.ac.uk/interpro/entry/IPR009009 InterPro IPR010611 http://www.ebi.ac.uk/interpro/entry/IPR010611 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2784 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2784 KEGG_Gene eco:b2813 http://www.genome.jp/dbget-bin/www_bget?eco:b2813 KEGG_Orthology KO:K08304 http://www.genome.jp/dbget-bin/www_bget?KO:K08304 OMA KREDMSM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KREDMSM PDB 2AE0 http://www.ebi.ac.uk/pdbe-srv/view/entry/2AE0 PDB 2GAE http://www.ebi.ac.uk/pdbe-srv/view/entry/2GAE PDB 2PI8 http://www.ebi.ac.uk/pdbe-srv/view/entry/2PI8 PDB 2PIC http://www.ebi.ac.uk/pdbe-srv/view/entry/2PIC PDB 2PJJ http://www.ebi.ac.uk/pdbe-srv/view/entry/2PJJ PDBsum 2AE0 http://www.ebi.ac.uk/pdbsum/2AE0 PDBsum 2GAE http://www.ebi.ac.uk/pdbsum/2GAE PDBsum 2PI8 http://www.ebi.ac.uk/pdbsum/2PI8 PDBsum 2PIC http://www.ebi.ac.uk/pdbsum/2PIC PDBsum 2PJJ http://www.ebi.ac.uk/pdbsum/2PJJ PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:MLTA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MLTA_ECOLI PSORT-B swissprot:MLTA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MLTA_ECOLI PSORT2 swissprot:MLTA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MLTA_ECOLI Pfam PF03562 http://pfam.xfam.org/family/PF03562 Pfam PF06725 http://pfam.xfam.org/family/PF06725 Phobius swissprot:MLTA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MLTA_ECOLI PhylomeDB P0A935 http://phylomedb.org/?seqid=P0A935 ProteinModelPortal P0A935 http://www.proteinmodelportal.org/query/uniprot/P0A935 PubMed 10037771 http://www.ncbi.nlm.nih.gov/pubmed/10037771 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8288527 http://www.ncbi.nlm.nih.gov/pubmed/8288527 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9287002 http://www.ncbi.nlm.nih.gov/pubmed/9287002 RefSeq NP_417293 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417293 RefSeq WP_000678646 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000678646 SMART SM00925 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00925 SMR P0A935 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A935 STRING 511145.b2813 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2813&targetmode=cogs STRING COG2821 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2821&targetmode=cogs SUPFAM SSF50685 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50685 UniProtKB MLTA_ECOLI http://www.uniprot.org/uniprot/MLTA_ECOLI UniProtKB-AC P0A935 http://www.uniprot.org/uniprot/P0A935 charge swissprot:MLTA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MLTA_ECOLI eggNOG COG2821 http://eggnogapi.embl.de/nog_data/html/tree/COG2821 eggNOG ENOG4105CA3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CA3 epestfind swissprot:MLTA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MLTA_ECOLI garnier swissprot:MLTA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MLTA_ECOLI helixturnhelix swissprot:MLTA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MLTA_ECOLI hmoment swissprot:MLTA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MLTA_ECOLI iep swissprot:MLTA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MLTA_ECOLI inforesidue swissprot:MLTA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MLTA_ECOLI octanol swissprot:MLTA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MLTA_ECOLI pepcoil swissprot:MLTA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MLTA_ECOLI pepdigest swissprot:MLTA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MLTA_ECOLI pepinfo swissprot:MLTA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MLTA_ECOLI pepnet swissprot:MLTA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MLTA_ECOLI pepstats swissprot:MLTA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MLTA_ECOLI pepwheel swissprot:MLTA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MLTA_ECOLI pepwindow swissprot:MLTA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MLTA_ECOLI sigcleave swissprot:MLTA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MLTA_ECOLI ## Database ID URL or Descriptions # AltName TEHB_ECOLI Chalcogen-detoxifying protein TehB # AltName TEHB_ECOLI Selenite methyltransferase # AltName TEHB_ECOLI Tellurite resistance protein TehB # BRENDA 2.1.1.265 2026 # BioGrid 4259401 4 # CATALYTIC ACTIVITY S-adenosyl-L-methionine + tellurite = S- adenosyl-L-homocysteine + methanetelluronate. {ECO:0000269|PubMed 21244361}. # CAUTION Was originally thought to be plasmid encoded. {ECO:0000305|PubMed 2060788}. # EcoGene EG11884 tehB # FUNCTION TEHB_ECOLI S-adenosyl-L-methionine dependent methyltransferase that catalyzes the methylation of tellurite and is responsible for tellurite resistance when present in high copy number. Can also methylate selenite and selenium dioxide. Is thus able to detoxify different chalcogens. Cannot methylate arsenic compounds. {ECO 0000269|PubMed 11053398, ECO 0000269|PubMed 21244361}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008757 S-adenosylmethionine-dependent methyltransferase activity; IDA:EcoCyc. # GO_process GO:0009636 response to toxic substance; IEA:UniProtKB-KW. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GO_process GO:0046690 response to tellurium ion; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.150 -; 1. # IntAct P25397 7 # InterPro IPR004537 Tellurite-R_MeTrfase_TehB # InterPro IPR015985 TehB-like_dom # InterPro IPR029063 SAM-dependent_MTases # Organism TEHB_ECOLI Escherichia coli (strain K12) # PATRIC 32118144 VBIEscCol129921_1492 # PDB 2XVA X-ray; 1.90 A; A/B/C/D=1-197 # PDB 2XVM X-ray; 1.48 A; A/B=1-197 # PIR A64895 A64895 # Pfam PF03848 TehB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TEHB_ECOLI Tellurite methyltransferase # RefSeq NP_415947 NC_000913.3 # RefSeq WP_000586732 NZ_LN832404.1 # SIMILARITY Belongs to the TehB family. {ECO 0000305}. # SUBCELLULAR LOCATION TEHB_ECOLI Cytoplasm {ECO 0000305|PubMed 11053398}. Note=Probably a peripheral membrane protein that interacts with TehA. # SUBUNIT Homodimer. {ECO:0000305|PubMed 11053398}. # SUPFAM SSF53335 SSF53335 # TIGRFAMs TIGR00477 tehB # eggNOG COG0500 LUCA # eggNOG ENOG41088CC Bacteria BLAST swissprot:TEHB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TEHB_ECOLI BioCyc ECOL316407:JW1426-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1426-MONOMER BioCyc EcoCyc:EG11884-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11884-MONOMER BioCyc MetaCyc:EG11884-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11884-MONOMER DIP DIP-10978N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10978N DOI 10.1016/0378-1119(91)90217-Y http://dx.doi.org/10.1016/0378-1119(91)90217-Y DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/BJ20102014 http://dx.doi.org/10.1042/BJ20102014 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1107/S1744309110036043 http://dx.doi.org/10.1107/S1744309110036043 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.22.6509-6513.2000 http://dx.doi.org/10.1128/JB.182.22.6509-6513.2000 EC_number EC:2.1.1.265 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.265 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M74072 http://www.ebi.ac.uk/ena/data/view/M74072 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.1.1.265 http://enzyme.expasy.org/EC/2.1.1.265 EcoGene EG11884 http://www.ecogene.org/geneInfo.php?eg_id=EG11884 EnsemblBacteria AAC74512 http://www.ensemblgenomes.org/id/AAC74512 EnsemblBacteria AAC74512 http://www.ensemblgenomes.org/id/AAC74512 EnsemblBacteria BAA15059 http://www.ensemblgenomes.org/id/BAA15059 EnsemblBacteria BAA15059 http://www.ensemblgenomes.org/id/BAA15059 EnsemblBacteria BAA15059 http://www.ensemblgenomes.org/id/BAA15059 EnsemblBacteria b1430 http://www.ensemblgenomes.org/id/b1430 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008757 GO_process GO:0009636 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009636 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GO_process GO:0046690 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046690 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 GeneID 945979 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945979 HOGENOM HOG000120596 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120596&db=HOGENOM6 InParanoid P25397 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P25397 IntAct P25397 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P25397* IntEnz 2.1.1.265 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.265 InterPro IPR004537 http://www.ebi.ac.uk/interpro/entry/IPR004537 InterPro IPR015985 http://www.ebi.ac.uk/interpro/entry/IPR015985 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 KEGG_Gene ecj:JW1426 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1426 KEGG_Gene eco:b1430 http://www.genome.jp/dbget-bin/www_bget?eco:b1430 MINT MINT-1274665 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1274665 OMA WDKNPMS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WDKNPMS PDB 2XVA http://www.ebi.ac.uk/pdbe-srv/view/entry/2XVA PDB 2XVM http://www.ebi.ac.uk/pdbe-srv/view/entry/2XVM PDBsum 2XVA http://www.ebi.ac.uk/pdbsum/2XVA PDBsum 2XVM http://www.ebi.ac.uk/pdbsum/2XVM PSORT swissprot:TEHB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TEHB_ECOLI PSORT-B swissprot:TEHB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TEHB_ECOLI PSORT2 swissprot:TEHB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TEHB_ECOLI Pfam PF03848 http://pfam.xfam.org/family/PF03848 Phobius swissprot:TEHB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TEHB_ECOLI PhylomeDB P25397 http://phylomedb.org/?seqid=P25397 ProteinModelPortal P25397 http://www.proteinmodelportal.org/query/uniprot/P25397 PubMed 11053398 http://www.ncbi.nlm.nih.gov/pubmed/11053398 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2060788 http://www.ncbi.nlm.nih.gov/pubmed/2060788 PubMed 21045305 http://www.ncbi.nlm.nih.gov/pubmed/21045305 PubMed 21244361 http://www.ncbi.nlm.nih.gov/pubmed/21244361 PubMed 8169225 http://www.ncbi.nlm.nih.gov/pubmed/8169225 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415947 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415947 RefSeq WP_000586732 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000586732 SMR P25397 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P25397 STRING 511145.b1430 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1430&targetmode=cogs SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 TIGRFAMs TIGR00477 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00477 UniProtKB TEHB_ECOLI http://www.uniprot.org/uniprot/TEHB_ECOLI UniProtKB-AC P25397 http://www.uniprot.org/uniprot/P25397 charge swissprot:TEHB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TEHB_ECOLI eggNOG COG0500 http://eggnogapi.embl.de/nog_data/html/tree/COG0500 eggNOG ENOG41088CC http://eggnogapi.embl.de/nog_data/html/tree/ENOG41088CC epestfind swissprot:TEHB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TEHB_ECOLI garnier swissprot:TEHB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TEHB_ECOLI helixturnhelix swissprot:TEHB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TEHB_ECOLI hmoment swissprot:TEHB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TEHB_ECOLI iep swissprot:TEHB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TEHB_ECOLI inforesidue swissprot:TEHB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TEHB_ECOLI octanol swissprot:TEHB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TEHB_ECOLI pepcoil swissprot:TEHB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TEHB_ECOLI pepdigest swissprot:TEHB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TEHB_ECOLI pepinfo swissprot:TEHB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TEHB_ECOLI pepnet swissprot:TEHB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TEHB_ECOLI pepstats swissprot:TEHB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TEHB_ECOLI pepwheel swissprot:TEHB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TEHB_ECOLI pepwindow swissprot:TEHB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TEHB_ECOLI sigcleave swissprot:TEHB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TEHB_ECOLI ## Database ID URL or Descriptions # EcoGene EG40003 insC6 # FUNCTION INSC6_ECOLI Involved in the transposition of the insertion sequence IS2. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 1.10.10.60 -; 1. # InterPro IPR002514 Transposase_8 # InterPro IPR009057 Homeodomain-like # Organism INSC6_ECOLI Escherichia coli (strain K12) # PIR B65240 B65240 # Pfam PF01527 HTH_Tnp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSC6_ECOLI Transposase InsC for insertion element IS2K # RefSeq NP_414894 NC_000913.3 # RefSeq NP_415921 NC_000913.3 # RefSeq NP_417338 NC_000913.3 # RefSeq NP_417516 NC_000913.3 # RefSeq NP_418692 NC_000913.3 # RefSeq WP_000567766 NZ_LN832404.1 # RefSeq YP_026163 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA97168.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAE78268.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the transposase 8 family. {ECO 0000305}. # SUPFAM SSF46689 SSF46689 # eggNOG COG2963 LUCA # eggNOG ENOG4108ZQS Bacteria BLAST swissprot:INSC6_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSC6_ECOLI BioCyc EcoCyc:MONOMER0-4254 http://biocyc.org/getid?id=EcoCyc:MONOMER0-4254 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB4711 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4711 EcoGene EG40003 http://www.ecogene.org/geneInfo.php?eg_id=EG40003 EnsemblBacteria AAC77228 http://www.ensemblgenomes.org/id/AAC77228 EnsemblBacteria AAC77228 http://www.ensemblgenomes.org/id/AAC77228 EnsemblBacteria BAE78268 http://www.ensemblgenomes.org/id/BAE78268 EnsemblBacteria BAE78268 http://www.ensemblgenomes.org/id/BAE78268 EnsemblBacteria BAE78268 http://www.ensemblgenomes.org/id/BAE78268 EnsemblBacteria b4272 http://www.ensemblgenomes.org/id/b4272 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 GeneID 945025 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945025 GeneID 945967 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945967 GeneID 946455 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946455 GeneID 947347 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947347 GeneID 947520 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947520 GeneID 948781 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948781 InParanoid P0CF45 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CF45 InterPro IPR002514 http://www.ebi.ac.uk/interpro/entry/IPR002514 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 KEGG_Gene ecj:JW4229 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4229 KEGG_Gene eco:b0360 http://www.genome.jp/dbget-bin/www_bget?eco:b0360 KEGG_Gene eco:b1403 http://www.genome.jp/dbget-bin/www_bget?eco:b1403 KEGG_Gene eco:b1997 http://www.genome.jp/dbget-bin/www_bget?eco:b1997 KEGG_Gene eco:b2861 http://www.genome.jp/dbget-bin/www_bget?eco:b2861 KEGG_Gene eco:b3044 http://www.genome.jp/dbget-bin/www_bget?eco:b3044 KEGG_Gene eco:b4272 http://www.genome.jp/dbget-bin/www_bget?eco:b4272 PSORT swissprot:INSC6_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSC6_ECOLI PSORT-B swissprot:INSC6_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSC6_ECOLI PSORT2 swissprot:INSC6_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSC6_ECOLI Pfam PF01527 http://pfam.xfam.org/family/PF01527 Phobius swissprot:INSC6_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSC6_ECOLI PhylomeDB P0CF45 http://phylomedb.org/?seqid=P0CF45 ProteinModelPortal P0CF45 http://www.proteinmodelportal.org/query/uniprot/P0CF45 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414894 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414894 RefSeq NP_415921 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415921 RefSeq NP_417338 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417338 RefSeq NP_417516 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417516 RefSeq NP_418692 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418692 RefSeq WP_000567766 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000567766 RefSeq YP_026163 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026163 STRING 511145.b4272 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4272&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 UniProtKB INSC6_ECOLI http://www.uniprot.org/uniprot/INSC6_ECOLI UniProtKB-AC P0CF45 http://www.uniprot.org/uniprot/P0CF45 charge swissprot:INSC6_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSC6_ECOLI eggNOG COG2963 http://eggnogapi.embl.de/nog_data/html/tree/COG2963 eggNOG ENOG4108ZQS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZQS epestfind swissprot:INSC6_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSC6_ECOLI garnier swissprot:INSC6_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSC6_ECOLI helixturnhelix swissprot:INSC6_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSC6_ECOLI hmoment swissprot:INSC6_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSC6_ECOLI iep swissprot:INSC6_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSC6_ECOLI inforesidue swissprot:INSC6_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSC6_ECOLI octanol swissprot:INSC6_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSC6_ECOLI pepcoil swissprot:INSC6_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSC6_ECOLI pepdigest swissprot:INSC6_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSC6_ECOLI pepinfo swissprot:INSC6_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSC6_ECOLI pepnet swissprot:INSC6_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSC6_ECOLI pepstats swissprot:INSC6_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSC6_ECOLI pepwheel swissprot:INSC6_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSC6_ECOLI pepwindow swissprot:INSC6_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSC6_ECOLI sigcleave swissprot:INSC6_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSC6_ECOLI ## Database ID URL or Descriptions # DISRUPTION PHENOTYPE Not essential, no change in sensitivity to reductant (beta-mercaptoethanol). {ECO:0000269|PubMed 23749980}. # EcoGene EG11114 appX # FUNCTION APPX_ECOLI Might be part of cytochrome bd-II oxidase (appB and appC). Able to restore reductant resistance to a cydX deletion mutant upon overexpression. CyxD and this protein may have some functional overlap. {ECO 0000269|PubMed 23749980}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # INDUCTION APPX_ECOLI Expressed during stationary phase (PubMed 19121005) and in minimal glycerol medium, at 45 degrees Celsius, strongly (30- fold) induced in low oxygen (PubMed 19734316) (at protein level). {ECO 0000269|PubMed 19121005, ECO 0000269|PubMed 19734316}. # InterPro IPR012994 YbgT_YccB # Organism APPX_ECOLI Escherichia coli (strain K12) # PATRIC 32117181 VBIEscCol129921_1014 # PIR A36733 A36733 # Pfam PF08173 YbgT_YccB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName APPX_ECOLI Putative cytochrome bd-II ubiquinol oxidase subunit AppX # RefSeq WP_000270305 NZ_LN832404.1 # RefSeq YP_001165313 NC_000913.3 # SIMILARITY Belongs to the cytochrome ubiquinol oxidase subunit X family. {ECO 0000305}. # SUBCELLULAR LOCATION APPX_ECOLI Cell inner membrane {ECO 0000305}; Single- pass membrane protein {ECO 0000305}. Note=In sucrose cushions fractionates with the outer membrane, in sarcosyl fractionation with the inner membrane. May have its C-terminus in the cytoplasm (PubMed 21778229). {ECO 0000269|PubMed 21778229}. # SUBUNIT APPX_ECOLI Able to interact with CydA and CydB upon overexpression. # TCDB 9.B.85.1 the 1 tms cydx/appx cytochrome bd oxidase activating (cydx/appx) family BLAST swissprot:APPX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:APPX_ECOLI BioCyc EcoCyc:MONOMER0-2817 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2817 DOI 10.1007/BF00267454 http://dx.doi.org/10.1007/BF00267454 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M111.245696 http://dx.doi.org/10.1074/jbc.M111.245696 DOI 10.1111/j.1365-2958.2008.06495.x http://dx.doi.org/10.1111/j.1365-2958.2008.06495.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00324-13 http://dx.doi.org/10.1128/JB.00324-13 DOI 10.1128/JB.00872-09 http://dx.doi.org/10.1128/JB.00872-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M58708 http://www.ebi.ac.uk/ena/data/view/M58708 EMBL S63811 http://www.ebi.ac.uk/ena/data/view/S63811 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1105 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1105 EcoGene EG11114 http://www.ecogene.org/geneInfo.php?eg_id=EG11114 EnsemblBacteria ABP93439 http://www.ensemblgenomes.org/id/ABP93439 EnsemblBacteria ABP93439 http://www.ensemblgenomes.org/id/ABP93439 EnsemblBacteria b4592 http://www.ensemblgenomes.org/id/b4592 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 948955 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948955 HOGENOM HOG000009400 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009400&db=HOGENOM6 InterPro IPR012994 http://www.ebi.ac.uk/interpro/entry/IPR012994 KEGG_Gene eco:b4592 http://www.genome.jp/dbget-bin/www_bget?eco:b4592 PSORT swissprot:APPX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:APPX_ECOLI PSORT-B swissprot:APPX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:APPX_ECOLI PSORT2 swissprot:APPX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:APPX_ECOLI Pfam PF08173 http://pfam.xfam.org/family/PF08173 Phobius swissprot:APPX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:APPX_ECOLI ProteinModelPortal P24244 http://www.proteinmodelportal.org/query/uniprot/P24244 PubMed 1658595 http://www.ncbi.nlm.nih.gov/pubmed/1658595 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19121005 http://www.ncbi.nlm.nih.gov/pubmed/19121005 PubMed 19734316 http://www.ncbi.nlm.nih.gov/pubmed/19734316 PubMed 2168385 http://www.ncbi.nlm.nih.gov/pubmed/2168385 PubMed 21778229 http://www.ncbi.nlm.nih.gov/pubmed/21778229 PubMed 23749980 http://www.ncbi.nlm.nih.gov/pubmed/23749980 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000270305 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000270305 RefSeq YP_001165313 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001165313 STRING 511145.b4592 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4592&targetmode=cogs TCDB 9.B.85.1 http://www.tcdb.org/search/result.php?tc=9.B.85.1 UniProtKB APPX_ECOLI http://www.uniprot.org/uniprot/APPX_ECOLI UniProtKB-AC P24244 http://www.uniprot.org/uniprot/P24244 charge swissprot:APPX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:APPX_ECOLI epestfind swissprot:APPX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:APPX_ECOLI garnier swissprot:APPX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:APPX_ECOLI helixturnhelix swissprot:APPX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:APPX_ECOLI hmoment swissprot:APPX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:APPX_ECOLI iep swissprot:APPX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:APPX_ECOLI inforesidue swissprot:APPX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:APPX_ECOLI octanol swissprot:APPX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:APPX_ECOLI pepcoil swissprot:APPX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:APPX_ECOLI pepdigest swissprot:APPX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:APPX_ECOLI pepinfo swissprot:APPX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:APPX_ECOLI pepnet swissprot:APPX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:APPX_ECOLI pepstats swissprot:APPX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:APPX_ECOLI pepwheel swissprot:APPX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:APPX_ECOLI pepwindow swissprot:APPX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:APPX_ECOLI sigcleave swissprot:APPX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:APPX_ECOLI ## Database ID URL or Descriptions # BioGrid 4259580 7 # EcoGene EG12601 yjjY # Organism YJJY_ECOLI Escherichia coli (strain K12) # PIR S56626 S56626 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJJY_ECOLI Uncharacterized protein YjjY # RefSeq NP_418819 NC_000913.3 # RefSeq WP_001303782 NZ_LN832404.1 # eggNOG ENOG410759A Bacteria # eggNOG ENOG410ZDAZ LUCA BLAST swissprot:YJJY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJJY_ECOLI BioCyc ECOL316407:JW4365-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4365-MONOMER BioCyc EcoCyc:G7954-MONOMER http://biocyc.org/getid?id=EcoCyc:G7954-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2486 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2486 EcoGene EG12601 http://www.ecogene.org/geneInfo.php?eg_id=EG12601 EnsemblBacteria AAC77355 http://www.ensemblgenomes.org/id/AAC77355 EnsemblBacteria AAC77355 http://www.ensemblgenomes.org/id/AAC77355 EnsemblBacteria BAE78391 http://www.ensemblgenomes.org/id/BAE78391 EnsemblBacteria BAE78391 http://www.ensemblgenomes.org/id/BAE78391 EnsemblBacteria BAE78391 http://www.ensemblgenomes.org/id/BAE78391 EnsemblBacteria b4402 http://www.ensemblgenomes.org/id/b4402 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 948925 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948925 HOGENOM HOG000009694 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009694&db=HOGENOM6 KEGG_Gene ecj:JW4365 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4365 KEGG_Gene eco:b4402 http://www.genome.jp/dbget-bin/www_bget?eco:b4402 PSORT swissprot:YJJY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJJY_ECOLI PSORT-B swissprot:YJJY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJJY_ECOLI PSORT2 swissprot:YJJY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJJY_ECOLI Phobius swissprot:YJJY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJJY_ECOLI ProteinModelPortal P0ADD9 http://www.proteinmodelportal.org/query/uniprot/P0ADD9 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418819 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418819 RefSeq WP_001303782 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001303782 STRING 511145.b4402 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4402&targetmode=cogs UniProtKB YJJY_ECOLI http://www.uniprot.org/uniprot/YJJY_ECOLI UniProtKB-AC P0ADD9 http://www.uniprot.org/uniprot/P0ADD9 charge swissprot:YJJY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJJY_ECOLI eggNOG ENOG410759A http://eggnogapi.embl.de/nog_data/html/tree/ENOG410759A eggNOG ENOG410ZDAZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZDAZ epestfind swissprot:YJJY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJJY_ECOLI garnier swissprot:YJJY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJJY_ECOLI helixturnhelix swissprot:YJJY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJJY_ECOLI hmoment swissprot:YJJY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJJY_ECOLI iep swissprot:YJJY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJJY_ECOLI inforesidue swissprot:YJJY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJJY_ECOLI octanol swissprot:YJJY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJJY_ECOLI pepcoil swissprot:YJJY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJJY_ECOLI pepdigest swissprot:YJJY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJJY_ECOLI pepinfo swissprot:YJJY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJJY_ECOLI pepnet swissprot:YJJY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJJY_ECOLI pepstats swissprot:YJJY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJJY_ECOLI pepwheel swissprot:YJJY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJJY_ECOLI pepwindow swissprot:YJJY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJJY_ECOLI sigcleave swissprot:YJJY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJJY_ECOLI ## Database ID URL or Descriptions # AltName DNase TatD {ECO:0000255|HAMAP-Rule MF_00901, ECO:0000305} # BioGrid 4261335 12 # CATALYTIC ACTIVITY TATD_ECOLI Exonucleolytic cleavage in the 3'- to 5'- direction to yield nucleoside 5'-phosphates. {ECO 0000255|HAMAP- Rule MF_00901, ECO 0000269|PubMed 25114049}. # CAUTION TATD_ECOLI Was suggested to be a central component of a quality control system that is linked to the Tat translocation system (PubMed 19343049). However, it was shown later that malfolded Tat substrates are Tat-independently degraded and that TatD is not involved in quality control of the Tat substrates (PubMed 20659466). {ECO 0000305|PubMed 19343049, ECO 0000305|PubMed 20659466}. # COFACTOR TATD_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_00901, ECO 0000269|PubMed 10747959, ECO 0000269|PubMed 25114049}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 25114049}; Note=No activity in the presence of Ca(2+) or Zn(2+). {ECO 0000269|PubMed 25114049}; # DISRUPTION PHENOTYPE Knockout cells are less resistant to the DNA damaging agent H(2)O(2). {ECO:0000269|PubMed 25114049}. # EcoGene EG11481 tatD # FUNCTION TATD_ECOLI 3'-5' exonuclease that prefers single-stranded DNA and RNA. May play a role in the H(2)O(2)-induced DNA damage repair. {ECO 0000255|HAMAP-Rule MF_00901, ECO 0000269|PubMed 10747959, ECO 0000269|PubMed 25114049}. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000175 3'-5'-exoribonuclease activity; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0004536 deoxyribonuclease activity; IDA:EcoCyc. # GO_function GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity; IDA:EcoCyc. # GO_function GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro. # GO_function GO:0046872 metal ion binding; IDA:EcoliWiki. # GO_process GO:0000738 DNA catabolic process, exonucleolytic; IDA:EcoCyc. # GO_process GO:0042542 response to hydrogen peroxide; IMP:EcoCyc. # GO_process GO:0090501 RNA phosphodiester bond hydrolysis; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0004518 nuclease activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # HAMAP MF_00901 TatD_exonuclease # INDUCTION Constitutively expressed. {ECO:0000269|PubMed 11160116}. # InterPro IPR001130 TatD_family # InterPro IPR018228 DNase_TatD-rel_CS # InterPro IPR024918 Exonuc_TatD # InterPro IPR032466 Metal_Hydrolase # KEGG_Brite ko01000 Enzymes # Organism TATD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10060 PTHR10060 # PATRIC 32123179 VBIEscCol129921_3955 # PDB 1XWY X-ray; 2.00 A; A=1-260 # PDB 4P5U X-ray; 2.00 A; A=1-260 # PDB 4PE8 X-ray; 2.89 A; A=1-260 # PIR A65189 A65189 # PIRSF PIRSF005902 DNase_TatD # PROSITE PS01090 TATD_2 # PROSITE PS01091 TATD_3 # Pfam PF01026 TatD_DNase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 3'-5' ssDNA/RNA exonuclease TatD {ECO:0000255|HAMAP-Rule MF_00901, ECO:0000305} # RefSeq WP_000459630 NZ_LN832404.1 # RefSeq YP_026271 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA67636.1; Type=Frameshift; Positions=160; Evidence={ECO:0000305}; Sequence=AAA67637.1; Type=Frameshift; Positions=182; Evidence={ECO 0000305}; Sequence=CAA06727.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; # SIMILARITY Belongs to the TatD-type hydrolase family. TatD subfamily. {ECO:0000255|HAMAP-Rule MF_00901, ECO:0000305}. # SUBCELLULAR LOCATION TATD_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00901, ECO 0000269|PubMed 10747959, ECO 0000269|PubMed 25114049}. # SUBUNIT TATD_ECOLI Monomer. {ECO 0000255|HAMAP-Rule MF_00901, ECO 0000269|PubMed 10747959, ECO 0000269|PubMed 25114049, ECO 0000269|Ref.11}. # SUPFAM SSF51556 SSF51556 # eggNOG COG0084 LUCA # eggNOG ENOG4105F8V Bacteria BLAST swissprot:TATD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TATD_ECOLI BioCyc ECOL316407:JW5931-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5931-MONOMER BioCyc EcoCyc:EG11481-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11481-MONOMER BioCyc MetaCyc:EG11481-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11481-MONOMER COG COG0084 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0084 DOI 10.1016/j.febslet.2010.07.039 http://dx.doi.org/10.1016/j.febslet.2010.07.039 DOI 10.1038/embor.2009.34 http://dx.doi.org/10.1038/embor.2009.34 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M000800200 http://dx.doi.org/10.1074/jbc.M000800200 DOI 10.1093/emboj/17.13.3640 http://dx.doi.org/10.1093/emboj/17.13.3640 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1093/nar/gku732 http://dx.doi.org/10.1093/nar/gku732 DOI 10.1111/j.1365-2958.1992.tb02166.x http://dx.doi.org/10.1111/j.1365-2958.1992.tb02166.x DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.183.5.1801-1804.2001 http://dx.doi.org/10.1128/JB.183.5.1801-1804.2001 EC_number EC:3.1.11.- {ECO:0000255|HAMAP-Rule:MF_00901, ECO:0000305|PubMed:25114049} http://www.genome.jp/dbget-bin/www_bget?EC:3.1.11.- {ECO:0000255|HAMAP-Rule:MF_00901, ECO:0000305|PubMed:25114049} EC_number EC:3.1.13.- {ECO:0000255|HAMAP-Rule:MF_00901, ECO:0000305|PubMed:25114049} http://www.genome.jp/dbget-bin/www_bget?EC:3.1.13.- {ECO:0000255|HAMAP-Rule:MF_00901, ECO:0000305|PubMed:25114049} EMBL AJ005830 http://www.ebi.ac.uk/ena/data/view/AJ005830 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X65013 http://www.ebi.ac.uk/ena/data/view/X65013 ENZYME 3.1.11.- {ECO:0000255|HAMAP-Rule:MF_00901, ECO:0000305|PubMed:25114049} http://enzyme.expasy.org/EC/3.1.11.- {ECO:0000255|HAMAP-Rule:MF_00901, ECO:0000305|PubMed:25114049} ENZYME 3.1.13.- {ECO:0000255|HAMAP-Rule:MF_00901, ECO:0000305|PubMed:25114049} http://enzyme.expasy.org/EC/3.1.13.- {ECO:0000255|HAMAP-Rule:MF_00901, ECO:0000305|PubMed:25114049} EchoBASE EB1446 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1446 EcoGene EG11481 http://www.ecogene.org/geneInfo.php?eg_id=EG11481 EnsemblBacteria AAT48229 http://www.ensemblgenomes.org/id/AAT48229 EnsemblBacteria AAT48229 http://www.ensemblgenomes.org/id/AAT48229 EnsemblBacteria BAE77462 http://www.ensemblgenomes.org/id/BAE77462 EnsemblBacteria BAE77462 http://www.ensemblgenomes.org/id/BAE77462 EnsemblBacteria BAE77462 http://www.ensemblgenomes.org/id/BAE77462 EnsemblBacteria b4483 http://www.ensemblgenomes.org/id/b4483 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000175 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000175 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0004536 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004536 GO_function GO:0008310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008310 GO_function GO:0016888 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016888 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0000738 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000738 GO_process GO:0042542 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042542 GO_process GO:0090501 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090501 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 GeneID 2847752 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2847752 HAMAP MF_00901 http://hamap.expasy.org/unirule/MF_00901 HOGENOM HOG000201523 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000201523&db=HOGENOM6 InParanoid P27859 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P27859 IntEnz 3.1.11.- {ECO:0000255|HAMAP-Rule:MF_00901, ECO:0000305|PubMed:25114049} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.11.- {ECO:0000255|HAMAP-Rule:MF_00901, ECO:0000305|PubMed:25114049} IntEnz 3.1.13.- {ECO:0000255|HAMAP-Rule:MF_00901, ECO:0000305|PubMed:25114049} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.13.- {ECO:0000255|HAMAP-Rule:MF_00901, ECO:0000305|PubMed:25114049} InterPro IPR001130 http://www.ebi.ac.uk/interpro/entry/IPR001130 InterPro IPR018228 http://www.ebi.ac.uk/interpro/entry/IPR018228 InterPro IPR024918 http://www.ebi.ac.uk/interpro/entry/IPR024918 InterPro IPR032466 http://www.ebi.ac.uk/interpro/entry/IPR032466 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5931 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5931 KEGG_Gene eco:b4483 http://www.genome.jp/dbget-bin/www_bget?eco:b4483 KEGG_Orthology KO:K03424 http://www.genome.jp/dbget-bin/www_bget?KO:K03424 OMA GCWSTAG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GCWSTAG PANTHER PTHR10060 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10060 PDB 1XWY http://www.ebi.ac.uk/pdbe-srv/view/entry/1XWY PDB 4P5U http://www.ebi.ac.uk/pdbe-srv/view/entry/4P5U PDB 4PE8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4PE8 PDBsum 1XWY http://www.ebi.ac.uk/pdbsum/1XWY PDBsum 4P5U http://www.ebi.ac.uk/pdbsum/4P5U PDBsum 4PE8 http://www.ebi.ac.uk/pdbsum/4PE8 PROSITE PS01090 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01090 PROSITE PS01091 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01091 PSORT swissprot:TATD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TATD_ECOLI PSORT-B swissprot:TATD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TATD_ECOLI PSORT2 swissprot:TATD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TATD_ECOLI Pfam PF01026 http://pfam.xfam.org/family/PF01026 Phobius swissprot:TATD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TATD_ECOLI PhylomeDB P27859 http://phylomedb.org/?seqid=P27859 ProteinModelPortal P27859 http://www.proteinmodelportal.org/query/uniprot/P27859 PubMed 10747959 http://www.ncbi.nlm.nih.gov/pubmed/10747959 PubMed 11160116 http://www.ncbi.nlm.nih.gov/pubmed/11160116 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 1584020 http://www.ncbi.nlm.nih.gov/pubmed/1584020 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19343049 http://www.ncbi.nlm.nih.gov/pubmed/19343049 PubMed 20659466 http://www.ncbi.nlm.nih.gov/pubmed/20659466 PubMed 25114049 http://www.ncbi.nlm.nih.gov/pubmed/25114049 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9649434 http://www.ncbi.nlm.nih.gov/pubmed/9649434 RefSeq WP_000459630 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000459630 RefSeq YP_026271 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026271 SMR P27859 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P27859 STRING 511145.b4483 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4483&targetmode=cogs STRING COG0084 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0084&targetmode=cogs SUPFAM SSF51556 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51556 UniProtKB TATD_ECOLI http://www.uniprot.org/uniprot/TATD_ECOLI UniProtKB-AC P27859 http://www.uniprot.org/uniprot/P27859 charge swissprot:TATD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TATD_ECOLI eggNOG COG0084 http://eggnogapi.embl.de/nog_data/html/tree/COG0084 eggNOG ENOG4105F8V http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F8V epestfind swissprot:TATD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TATD_ECOLI garnier swissprot:TATD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TATD_ECOLI helixturnhelix swissprot:TATD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TATD_ECOLI hmoment swissprot:TATD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TATD_ECOLI iep swissprot:TATD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TATD_ECOLI inforesidue swissprot:TATD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TATD_ECOLI octanol swissprot:TATD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TATD_ECOLI pepcoil swissprot:TATD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TATD_ECOLI pepdigest swissprot:TATD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TATD_ECOLI pepinfo swissprot:TATD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TATD_ECOLI pepnet swissprot:TATD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TATD_ECOLI pepstats swissprot:TATD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TATD_ECOLI pepwheel swissprot:TATD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TATD_ECOLI pepwindow swissprot:TATD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TATD_ECOLI sigcleave swissprot:TATD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TATD_ECOLI ## Database ID URL or Descriptions # AltName YJGA_ECOLI x96 protein # BioGrid 4260635 10 # EcoGene EG11410 yjgA # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # Gene3D 1.10.60.30 -; 2. # HAMAP MF_00765 UPF0307 # IntAct P0A8X0 5 # InterPro IPR006839 Ribosome-assoc_YjgA # InterPro IPR023153 PSPTO4464-like_domain # KEGG_Brite ko03009 Ribosome biogenesis # Organism YJGA_ECOLI Escherichia coli (strain K12) # PATRIC 32124041 VBIEscCol129921_4365 # PIR S56460 S56460 # PIRSF PIRSF016183 UCP016183 # Pfam PF04751 DUF615 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJGA_ECOLI UPF0307 protein YjgA # RefSeq NP_418655 NC_000913.3 # RefSeq WP_000166270 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0307 family. {ECO 0000305}. # SUBCELLULAR LOCATION YJGA_ECOLI Cytoplasm {ECO 0000269|PubMed 16980477}. Note=Has been seen to comigrate with the 50S ribosomal subunit in sucrose gradients. # eggNOG COG3028 LUCA # eggNOG ENOG4105N42 Bacteria BLAST swissprot:YJGA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJGA_ECOLI BioCyc ECOL316407:JW4193-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4193-MONOMER BioCyc EcoCyc:EG11410-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11410-MONOMER COG COG3028 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3028 DIP DIP-47895N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47895N DOI 10.1006/jmbi.1996.0103 http://dx.doi.org/10.1006/jmbi.1996.0103 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00444-06 http://dx.doi.org/10.1128/JB.00444-06 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D44452 http://www.ebi.ac.uk/ena/data/view/D44452 EMBL M95096 http://www.ebi.ac.uk/ena/data/view/M95096 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB1382 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1382 EcoGene EG11410 http://www.ecogene.org/geneInfo.php?eg_id=EG11410 EnsemblBacteria AAC77191 http://www.ensemblgenomes.org/id/AAC77191 EnsemblBacteria AAC77191 http://www.ensemblgenomes.org/id/AAC77191 EnsemblBacteria BAE78234 http://www.ensemblgenomes.org/id/BAE78234 EnsemblBacteria BAE78234 http://www.ensemblgenomes.org/id/BAE78234 EnsemblBacteria BAE78234 http://www.ensemblgenomes.org/id/BAE78234 EnsemblBacteria b4234 http://www.ensemblgenomes.org/id/b4234 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 Gene3D 1.10.60.30 http://www.cathdb.info/version/latest/superfamily/1.10.60.30 GeneID 948751 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948751 HAMAP MF_00765 http://hamap.expasy.org/unirule/MF_00765 HOGENOM HOG000013875 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000013875&db=HOGENOM6 InParanoid P0A8X0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8X0 IntAct P0A8X0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8X0* InterPro IPR006839 http://www.ebi.ac.uk/interpro/entry/IPR006839 InterPro IPR023153 http://www.ebi.ac.uk/interpro/entry/IPR023153 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW4193 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4193 KEGG_Gene eco:b4234 http://www.genome.jp/dbget-bin/www_bget?eco:b4234 KEGG_Orthology KO:K09889 http://www.genome.jp/dbget-bin/www_bget?KO:K09889 OMA WPNADRQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WPNADRQ PSORT swissprot:YJGA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJGA_ECOLI PSORT-B swissprot:YJGA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJGA_ECOLI PSORT2 swissprot:YJGA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJGA_ECOLI Pfam PF04751 http://pfam.xfam.org/family/PF04751 Phobius swissprot:YJGA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJGA_ECOLI PhylomeDB P0A8X0 http://phylomedb.org/?seqid=P0A8X0 ProteinModelPortal P0A8X0 http://www.proteinmodelportal.org/query/uniprot/P0A8X0 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16980477 http://www.ncbi.nlm.nih.gov/pubmed/16980477 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8604133 http://www.ncbi.nlm.nih.gov/pubmed/8604133 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418655 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418655 RefSeq WP_000166270 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000166270 SMR P0A8X0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8X0 STRING 511145.b4234 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4234&targetmode=cogs STRING COG3028 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3028&targetmode=cogs UniProtKB YJGA_ECOLI http://www.uniprot.org/uniprot/YJGA_ECOLI UniProtKB-AC P0A8X0 http://www.uniprot.org/uniprot/P0A8X0 charge swissprot:YJGA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJGA_ECOLI eggNOG COG3028 http://eggnogapi.embl.de/nog_data/html/tree/COG3028 eggNOG ENOG4105N42 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105N42 epestfind swissprot:YJGA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJGA_ECOLI garnier swissprot:YJGA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJGA_ECOLI helixturnhelix swissprot:YJGA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJGA_ECOLI hmoment swissprot:YJGA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJGA_ECOLI iep swissprot:YJGA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJGA_ECOLI inforesidue swissprot:YJGA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJGA_ECOLI octanol swissprot:YJGA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJGA_ECOLI pepcoil swissprot:YJGA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJGA_ECOLI pepdigest swissprot:YJGA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJGA_ECOLI pepinfo swissprot:YJGA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJGA_ECOLI pepnet swissprot:YJGA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJGA_ECOLI pepstats swissprot:YJGA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJGA_ECOLI pepwheel swissprot:YJGA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJGA_ECOLI pepwindow swissprot:YJGA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJGA_ECOLI sigcleave swissprot:YJGA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJGA_ECOLI ## Database ID URL or Descriptions # AltName TRUB_ECOLI Protein p35 # AltName tRNA pseudouridine(55) synthase {ECO:0000255|HAMAP-Rule MF_01080} # AltName tRNA pseudouridylate synthase {ECO:0000255|HAMAP-Rule MF_01080} # AltName tRNA-uridine isomerase {ECO:0000255|HAMAP-Rule MF_01080} # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=148 nM for tRNA (at pH 7.5) {ECO 0000269|PubMed:15581587}; # BRENDA 5.4.99.25 2026 # CATALYTIC ACTIVITY TRUB_ECOLI tRNA uridine(55) = tRNA pseudouridine(55). {ECO 0000255|HAMAP-Rule MF_01080, ECO 0000269|PubMed 7489483}. # EcoGene EG11177 truB # FUNCTION TRUB_ECOLI Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs. {ECO 0000255|HAMAP- Rule MF_01080, ECO 0000269|PubMed 11142385, ECO 0000269|PubMed 7489483}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003723 RNA binding; IEA:InterPro. # GO_function GO:0009982 pseudouridine synthase activity; IMP:EcoCyc. # GO_process GO:0001522 pseudouridine synthesis; IDA:EcoCyc. # GO_process GO:0006400 tRNA modification; IBA:GO_Central. # GO_process GO:0031119 tRNA pseudouridine synthesis; IEA:UniProtKB-HAMAP. # GO_process GO:1990481 mRNA pseudouridine synthesis; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 2.30.130.10 -; 1. # HAMAP MF_01080 TruB_bact # IntAct P60340 5 # InterPro IPR002501 PsdUridine_synth_N # InterPro IPR014780 tRNA_psdUridine_synth_TruB # InterPro IPR015240 tRNA_sdUridine_synth_fam1_C # InterPro IPR015947 PUA-like_domain # InterPro IPR020103 PsdUridine_synth_cat_dom # InterPro IPR032819 TruB_C # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # Organism TRUB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR13767 PTHR13767 # PATRIC 32121750 VBIEscCol129921_3261 # PDB 1K8W X-ray; 1.85 A; A=7-314 # PDB 1R3F X-ray; 1.85 A; A=1-314 # PDB 1ZL3 X-ray; 2.80 A; A=10-314 # PIR S01916 Q9EC35 # Pfam PF01509 TruB_N # Pfam PF09157 TruB-C_2 # Pfam PF16198 TruB_C_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName tRNA pseudouridine synthase B {ECO:0000255|HAMAP-Rule MF_01080} # RefSeq NP_417635 NC_000913.3 # RefSeq WP_000089698 NZ_LN832404.1 # SIMILARITY Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. {ECO:0000255|HAMAP-Rule MF_01080, ECO:0000305}. # SUPFAM SSF55120 SSF55120 # SUPFAM SSF88697 SSF88697 # TIGRFAMs TIGR00431 TruB # eggNOG COG0130 LUCA # eggNOG ENOG4105D0T Bacteria BLAST swissprot:TRUB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRUB_ECOLI BioCyc ECOL316407:JW3135-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3135-MONOMER BioCyc EcoCyc:EG11177-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11177-MONOMER BioCyc MetaCyc:EG11177-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11177-MONOMER COG COG0130 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0130 DOI 10.1016/S0092-8674(01)00618-3 http://dx.doi.org/10.1016/S0092-8674(01)00618-3 DOI 10.1016/j.abb.2004.09.009 http://dx.doi.org/10.1016/j.abb.2004.09.009 DOI 10.1017/S1355838200001588 http://dx.doi.org/10.1017/S1355838200001588 DOI 10.1021/bi001079n http://dx.doi.org/10.1021/bi001079n DOI 10.1021/bi9913911 http://dx.doi.org/10.1021/bi9913911 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.2135585100 http://dx.doi.org/10.1073/pnas.2135585100 DOI 10.1093/nar/16.22.10803 http://dx.doi.org/10.1093/nar/16.22.10803 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.4.99.25 {ECO:0000255|HAMAP-Rule:MF_01080, ECO:0000269|PubMed:7489483} http://www.genome.jp/dbget-bin/www_bget?EC:5.4.99.25 {ECO:0000255|HAMAP-Rule:MF_01080, ECO:0000269|PubMed:7489483} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL S79856 http://www.ebi.ac.uk/ena/data/view/S79856 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X13270 http://www.ebi.ac.uk/ena/data/view/X13270 EMBL X13775 http://www.ebi.ac.uk/ena/data/view/X13775 ENZYME 5.4.99.25 {ECO:0000255|HAMAP-Rule:MF_01080, ECO:0000269|PubMed:7489483} http://enzyme.expasy.org/EC/5.4.99.25 {ECO:0000255|HAMAP-Rule:MF_01080, ECO:0000269|PubMed:7489483} EchoBASE EB1164 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1164 EcoGene EG11177 http://www.ecogene.org/geneInfo.php?eg_id=EG11177 EnsemblBacteria AAC76200 http://www.ensemblgenomes.org/id/AAC76200 EnsemblBacteria AAC76200 http://www.ensemblgenomes.org/id/AAC76200 EnsemblBacteria BAE77212 http://www.ensemblgenomes.org/id/BAE77212 EnsemblBacteria BAE77212 http://www.ensemblgenomes.org/id/BAE77212 EnsemblBacteria BAE77212 http://www.ensemblgenomes.org/id/BAE77212 EnsemblBacteria b3166 http://www.ensemblgenomes.org/id/b3166 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0009982 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009982 GO_process GO:0001522 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001522 GO_process GO:0006400 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006400 GO_process GO:0031119 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031119 GO_process GO:1990481 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990481 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 2.30.130.10 http://www.cathdb.info/version/latest/superfamily/2.30.130.10 GeneID 947687 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947687 HAMAP MF_01080 http://hamap.expasy.org/unirule/MF_01080 HOGENOM HOG000231223 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231223&db=HOGENOM6 InParanoid P60340 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P60340 IntAct P60340 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P60340* IntEnz 5.4.99.25 {ECO:0000255|HAMAP-Rule:MF_01080, ECO:0000269|PubMed:7489483} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.4.99.25 {ECO:0000255|HAMAP-Rule:MF_01080, ECO:0000269|PubMed:7489483} InterPro IPR002501 http://www.ebi.ac.uk/interpro/entry/IPR002501 InterPro IPR014780 http://www.ebi.ac.uk/interpro/entry/IPR014780 InterPro IPR015240 http://www.ebi.ac.uk/interpro/entry/IPR015240 InterPro IPR015947 http://www.ebi.ac.uk/interpro/entry/IPR015947 InterPro IPR020103 http://www.ebi.ac.uk/interpro/entry/IPR020103 InterPro IPR032819 http://www.ebi.ac.uk/interpro/entry/IPR032819 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW3135 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3135 KEGG_Gene eco:b3166 http://www.genome.jp/dbget-bin/www_bget?eco:b3166 KEGG_Orthology KO:K03177 http://www.genome.jp/dbget-bin/www_bget?KO:K03177 OMA YELQFIR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YELQFIR PANTHER PTHR13767 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13767 PDB 1K8W http://www.ebi.ac.uk/pdbe-srv/view/entry/1K8W PDB 1R3F http://www.ebi.ac.uk/pdbe-srv/view/entry/1R3F PDB 1ZL3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZL3 PDBsum 1K8W http://www.ebi.ac.uk/pdbsum/1K8W PDBsum 1R3F http://www.ebi.ac.uk/pdbsum/1R3F PDBsum 1ZL3 http://www.ebi.ac.uk/pdbsum/1ZL3 PSORT swissprot:TRUB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRUB_ECOLI PSORT-B swissprot:TRUB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRUB_ECOLI PSORT2 swissprot:TRUB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRUB_ECOLI Pfam PF01509 http://pfam.xfam.org/family/PF01509 Pfam PF09157 http://pfam.xfam.org/family/PF09157 Pfam PF16198 http://pfam.xfam.org/family/PF16198 Phobius swissprot:TRUB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRUB_ECOLI PhylomeDB P60340 http://phylomedb.org/?seqid=P60340 ProteinModelPortal P60340 http://www.proteinmodelportal.org/query/uniprot/P60340 PubMed 10529181 http://www.ncbi.nlm.nih.gov/pubmed/10529181 PubMed 10924141 http://www.ncbi.nlm.nih.gov/pubmed/10924141 PubMed 11142385 http://www.ncbi.nlm.nih.gov/pubmed/11142385 PubMed 11779468 http://www.ncbi.nlm.nih.gov/pubmed/11779468 PubMed 14566049 http://www.ncbi.nlm.nih.gov/pubmed/14566049 PubMed 15581587 http://www.ncbi.nlm.nih.gov/pubmed/15581587 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2849753 http://www.ncbi.nlm.nih.gov/pubmed/2849753 PubMed 7489483 http://www.ncbi.nlm.nih.gov/pubmed/7489483 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417635 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417635 RefSeq WP_000089698 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000089698 SMR P60340 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P60340 STRING 511145.b3166 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3166&targetmode=cogs STRING COG0130 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0130&targetmode=cogs SUPFAM SSF55120 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55120 SUPFAM SSF88697 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF88697 TIGRFAMs TIGR00431 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00431 UniProtKB TRUB_ECOLI http://www.uniprot.org/uniprot/TRUB_ECOLI UniProtKB-AC P60340 http://www.uniprot.org/uniprot/P60340 charge swissprot:TRUB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRUB_ECOLI eggNOG COG0130 http://eggnogapi.embl.de/nog_data/html/tree/COG0130 eggNOG ENOG4105D0T http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D0T epestfind swissprot:TRUB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRUB_ECOLI garnier swissprot:TRUB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRUB_ECOLI helixturnhelix swissprot:TRUB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRUB_ECOLI hmoment swissprot:TRUB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRUB_ECOLI iep swissprot:TRUB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRUB_ECOLI inforesidue swissprot:TRUB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRUB_ECOLI octanol swissprot:TRUB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRUB_ECOLI pepcoil swissprot:TRUB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRUB_ECOLI pepdigest swissprot:TRUB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRUB_ECOLI pepinfo swissprot:TRUB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRUB_ECOLI pepnet swissprot:TRUB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRUB_ECOLI pepstats swissprot:TRUB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRUB_ECOLI pepwheel swissprot:TRUB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRUB_ECOLI pepwindow swissprot:TRUB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRUB_ECOLI sigcleave swissprot:TRUB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRUB_ECOLI ## Database ID URL or Descriptions # BioGrid 4259120 11 # EcoGene EG13850 ynfL # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; ISS:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR005119 LysR_subst-bd # InterPro IPR011991 WHTH_DNA-bd_dom # Organism YNFL_ECOLI Escherichia coli (strain K12) # PATRIC 32118492 VBIEscCol129921_1666 # PIR E64915 E64915 # PRINTS PR00039 HTHLYSR # PROSITE PS50931 HTH_LYSR # Pfam PF00126 HTH_1 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNFL_ECOLI Uncharacterized HTH-type transcriptional regulator YnfL # RefSeq NP_416112 NC_000913.3 # RefSeq WP_001019525 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lysR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00253}. # SUPFAM SSF46785 SSF46785 # eggNOG ENOG4106NZI Bacteria # eggNOG ENOG410YGF0 LUCA BLAST swissprot:YNFL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNFL_ECOLI BioCyc ECOL316407:JW1587-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1587-MONOMER BioCyc EcoCyc:G6853-MONOMER http://biocyc.org/getid?id=EcoCyc:G6853-MONOMER DIP DIP-12771N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12771N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3611 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3611 EcoGene EG13850 http://www.ecogene.org/geneInfo.php?eg_id=EG13850 EnsemblBacteria AAC74667 http://www.ensemblgenomes.org/id/AAC74667 EnsemblBacteria AAC74667 http://www.ensemblgenomes.org/id/AAC74667 EnsemblBacteria BAA15319 http://www.ensemblgenomes.org/id/BAA15319 EnsemblBacteria BAA15319 http://www.ensemblgenomes.org/id/BAA15319 EnsemblBacteria BAA15319 http://www.ensemblgenomes.org/id/BAA15319 EnsemblBacteria b1595 http://www.ensemblgenomes.org/id/b1595 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 946136 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946136 HOGENOM HOG000233514 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000233514&db=HOGENOM6 InParanoid P77559 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77559 IntAct P77559 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77559* InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW1587 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1587 KEGG_Gene eco:b1595 http://www.genome.jp/dbget-bin/www_bget?eco:b1595 OMA DAISEMW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DAISEMW PRINTS PR00039 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00039 PROSITE PS50931 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50931 PSORT swissprot:YNFL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNFL_ECOLI PSORT-B swissprot:YNFL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNFL_ECOLI PSORT2 swissprot:YNFL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNFL_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:YNFL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNFL_ECOLI PhylomeDB P77559 http://phylomedb.org/?seqid=P77559 ProteinModelPortal P77559 http://www.proteinmodelportal.org/query/uniprot/P77559 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416112 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416112 RefSeq WP_001019525 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001019525 SMR P77559 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77559 STRING 511145.b1595 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1595&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB YNFL_ECOLI http://www.uniprot.org/uniprot/YNFL_ECOLI UniProtKB-AC P77559 http://www.uniprot.org/uniprot/P77559 charge swissprot:YNFL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNFL_ECOLI eggNOG ENOG4106NZI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106NZI eggNOG ENOG410YGF0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YGF0 epestfind swissprot:YNFL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNFL_ECOLI garnier swissprot:YNFL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNFL_ECOLI helixturnhelix swissprot:YNFL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNFL_ECOLI hmoment swissprot:YNFL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNFL_ECOLI iep swissprot:YNFL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNFL_ECOLI inforesidue swissprot:YNFL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNFL_ECOLI octanol swissprot:YNFL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNFL_ECOLI pepcoil swissprot:YNFL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNFL_ECOLI pepdigest swissprot:YNFL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNFL_ECOLI pepinfo swissprot:YNFL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNFL_ECOLI pepnet swissprot:YNFL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNFL_ECOLI pepstats swissprot:YNFL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNFL_ECOLI pepwheel swissprot:YNFL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNFL_ECOLI pepwindow swissprot:YNFL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNFL_ECOLI sigcleave swissprot:YNFL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNFL_ECOLI ## Database ID URL or Descriptions # AltName CYDX_ECOLI Cytochrome bd-I oxidase subunit X # AltName CYDX_ECOLI Cytochrome d ubiquinol oxidase subunit X # BioGrid 4259450 12 # CATALYTIC ACTIVITY CYDX_ECOLI 2 ubiquinol + O(2) + 4 H(+)(Side 1) = 2 ubiquinone + 2 H(2)O + 4 H(+)(Side 2). # DISRUPTION PHENOTYPE Slow growth in aerobic liquid culture, forms mixed colonies on aerobic solid media, increased sensitivity to reductant (beta-mercapoethanol). Reduced cytochrome bd-I oxidase activity. {ECO:0000269|PubMed 23749980}. # EcoGene EG14329 cydX # FUNCTION CYDX_ECOLI Required for correct functioning of cytochrome bd-I oxidase. This protein and AppX may have some functional overlap. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; ISM:EcoCyc. # GO_component GO:0016020 membrane; IDA:EcoCyc. # GO_component GO:0019867 outer membrane; IDA:EcoCyc. # GO_function GO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors; IMP:EcoCyc. # GO_process GO:0006119 oxidative phosphorylation; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # INDUCTION CYDX_ECOLI Constitutively expressed during aerobic growth (PubMed 19121005), induced in low oxygen, and maybe by SDS/EDTA (envelope stress) (PubMed 19734316) (at protein level). {ECO 0000269|PubMed 19121005, ECO 0000269|PubMed 19734316}. # IntAct P56100 2 # InterPro IPR011724 Cyd_oper_YbgT # InterPro IPR012994 YbgT_YccB # Organism CYDX_ECOLI Escherichia coli (strain K12) # PATHWAY CYDX_ECOLI Energy metabolism; oxidative phosphorylation. # PATRIC 32116667 VBIEscCol129921_0766 # Pfam PF08173 YbgT_YccB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CYDX_ECOLI Cytochrome bd-I ubiquinol oxidase subunit X # RefSeq WP_000270282 NZ_LN832404.1 # RefSeq YP_588444 NC_000913.3 # SEQUENCE CAUTION Sequence=J03939; Type=Frameshift; Positions=22, 27; Evidence={ECO 0000305}; # SIMILARITY Belongs to the cytochrome ubiquinol oxidase subunit X family. {ECO 0000305}. # SUBCELLULAR LOCATION CYDX_ECOLI Cell inner membrane {ECO 0000305}; Single- pass membrane protein {ECO 0000305}. Note=In sucrose cushions fractionates with both the inner and outer membranes. {ECO 0000269|PubMed 19121005, ECO 0000269|PubMed 21778229}. # SUBUNIT May be a subunit of cytochrome bd-I ubiquinol oxidase. Probably interacts with CydA and CydB. {ECO:0000269|PubMed 23749980}. # TCDB 9.B.85.1 the 1 tms cydx/appx cytochrome bd oxidase activating (cydx/appx) family # TIGRFAMs TIGR02106 cyd_oper_ybgT # eggNOG COG4890 LUCA BLAST swissprot:CYDX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CYDX_ECOLI BioCyc ECOL316407:JW0724-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0724-MONOMER BioCyc EcoCyc:MONOMER0-2663 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2663 BioCyc MetaCyc:MONOMER0-2663 http://biocyc.org/getid?id=MetaCyc:MONOMER0-2663 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M111.245696 http://dx.doi.org/10.1074/jbc.M111.245696 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1111/j.1365-2958.2008.06495.x http://dx.doi.org/10.1111/j.1365-2958.2008.06495.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00324-13 http://dx.doi.org/10.1128/JB.00324-13 DOI 10.1128/JB.00872-09 http://dx.doi.org/10.1128/JB.00872-09 EC_number EC:1.10.3.14 http://www.genome.jp/dbget-bin/www_bget?EC:1.10.3.14 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J03939 http://www.ebi.ac.uk/ena/data/view/J03939 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U30934 http://www.ebi.ac.uk/ena/data/view/U30934 ENZYME 1.10.3.14 http://enzyme.expasy.org/EC/1.10.3.14 EchoBASE EB4075 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4075 EcoGene EG14329 http://www.ecogene.org/geneInfo.php?eg_id=EG14329 EnsemblBacteria ABD18645 http://www.ensemblgenomes.org/id/ABD18645 EnsemblBacteria ABD18645 http://www.ensemblgenomes.org/id/ABD18645 EnsemblBacteria BAE76359 http://www.ensemblgenomes.org/id/BAE76359 EnsemblBacteria BAE76359 http://www.ensemblgenomes.org/id/BAE76359 EnsemblBacteria BAE76359 http://www.ensemblgenomes.org/id/BAE76359 EnsemblBacteria b4515 http://www.ensemblgenomes.org/id/b4515 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0019867 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019867 GO_function GO:0016679 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016679 GO_process GO:0006119 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006119 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 1450246 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1450246 HOGENOM HOG000264864 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000264864&db=HOGENOM6 IntAct P56100 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P56100* IntEnz 1.10.3.14 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.10.3.14 InterPro IPR011724 http://www.ebi.ac.uk/interpro/entry/IPR011724 InterPro IPR012994 http://www.ebi.ac.uk/interpro/entry/IPR012994 KEGG_Gene ecj:JW0724 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0724 KEGG_Gene eco:b4515 http://www.genome.jp/dbget-bin/www_bget?eco:b4515 PSORT swissprot:CYDX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CYDX_ECOLI PSORT-B swissprot:CYDX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CYDX_ECOLI PSORT2 swissprot:CYDX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CYDX_ECOLI Pfam PF08173 http://pfam.xfam.org/family/PF08173 Phobius swissprot:CYDX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CYDX_ECOLI ProteinModelPortal P56100 http://www.proteinmodelportal.org/query/uniprot/P56100 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19121005 http://www.ncbi.nlm.nih.gov/pubmed/19121005 PubMed 19734316 http://www.ncbi.nlm.nih.gov/pubmed/19734316 PubMed 21778229 http://www.ncbi.nlm.nih.gov/pubmed/21778229 PubMed 23749980 http://www.ncbi.nlm.nih.gov/pubmed/23749980 PubMed 2843510 http://www.ncbi.nlm.nih.gov/pubmed/2843510 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 9068659 http://www.ncbi.nlm.nih.gov/pubmed/9068659 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000270282 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000270282 RefSeq YP_588444 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_588444 SMR P56100 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P56100 STRING 511145.b4515 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4515&targetmode=cogs TCDB 9.B.85.1 http://www.tcdb.org/search/result.php?tc=9.B.85.1 TIGRFAMs TIGR02106 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02106 UniProtKB CYDX_ECOLI http://www.uniprot.org/uniprot/CYDX_ECOLI UniProtKB-AC P56100 http://www.uniprot.org/uniprot/P56100 charge swissprot:CYDX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CYDX_ECOLI eggNOG COG4890 http://eggnogapi.embl.de/nog_data/html/tree/COG4890 epestfind swissprot:CYDX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CYDX_ECOLI garnier swissprot:CYDX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CYDX_ECOLI helixturnhelix swissprot:CYDX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CYDX_ECOLI hmoment swissprot:CYDX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CYDX_ECOLI iep swissprot:CYDX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CYDX_ECOLI inforesidue swissprot:CYDX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CYDX_ECOLI octanol swissprot:CYDX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CYDX_ECOLI pepcoil swissprot:CYDX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CYDX_ECOLI pepdigest swissprot:CYDX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CYDX_ECOLI pepinfo swissprot:CYDX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CYDX_ECOLI pepnet swissprot:CYDX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CYDX_ECOLI pepstats swissprot:CYDX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CYDX_ECOLI pepwheel swissprot:CYDX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CYDX_ECOLI pepwindow swissprot:CYDX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CYDX_ECOLI sigcleave swissprot:CYDX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CYDX_ECOLI ## Database ID URL or Descriptions # BioGrid 4263313 412 # EcoGene EG13576 wzxC # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006810 transport; IBA:GO_Central. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0006810 transport # GOslim_process GO:0009058 biosynthetic process # KEGG_Brite ko02000 Transporters # Organism WZXC_ECOLI Escherichia coli (strain K12) # PATHWAY WZXC_ECOLI Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. # PATRIC 32119425 VBIEscCol129921_2123 # PIR E64970 E64970 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName WZXC_ECOLI Lipopolysaccharide biosynthesis protein WzxC # RefSeq NP_416550 NC_000913.3 # RefSeq WP_000058424 NZ_LN832404.1 # SIMILARITY Belongs to the polysaccharide synthase family. {ECO 0000305}. # SUBCELLULAR LOCATION WZXC_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.66.2 the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily # eggNOG COG2244 LUCA # eggNOG ENOG4105PSV Bacteria BLAST swissprot:WZXC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:WZXC_ECOLI BioCyc ECOL316407:JW2031-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2031-MONOMER BioCyc EcoCyc:G7097-MONOMER http://biocyc.org/getid?id=EcoCyc:G7097-MONOMER COG COG2244 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2244 DIP DIP-11136N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11136N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U38473 http://www.ebi.ac.uk/ena/data/view/U38473 EchoBASE EB3346 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3346 EcoGene EG13576 http://www.ecogene.org/geneInfo.php?eg_id=EG13576 EnsemblBacteria AAC75107 http://www.ensemblgenomes.org/id/AAC75107 EnsemblBacteria AAC75107 http://www.ensemblgenomes.org/id/AAC75107 EnsemblBacteria BAA15899 http://www.ensemblgenomes.org/id/BAA15899 EnsemblBacteria BAA15899 http://www.ensemblgenomes.org/id/BAA15899 EnsemblBacteria BAA15899 http://www.ensemblgenomes.org/id/BAA15899 EnsemblBacteria b2046 http://www.ensemblgenomes.org/id/b2046 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 946581 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946581 HOGENOM HOG000121955 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000121955&db=HOGENOM6 InParanoid P77377 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77377 IntAct P77377 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77377* KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2031 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2031 KEGG_Gene eco:b2046 http://www.genome.jp/dbget-bin/www_bget?eco:b2046 KEGG_Orthology KO:K16695 http://www.genome.jp/dbget-bin/www_bget?KO:K16695 MINT MINT-1312635 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1312635 OMA EMKRQFC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EMKRQFC PSORT swissprot:WZXC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:WZXC_ECOLI PSORT-B swissprot:WZXC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:WZXC_ECOLI PSORT2 swissprot:WZXC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:WZXC_ECOLI Phobius swissprot:WZXC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:WZXC_ECOLI PhylomeDB P77377 http://phylomedb.org/?seqid=P77377 ProteinModelPortal P77377 http://www.proteinmodelportal.org/query/uniprot/P77377 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8759852 http://www.ncbi.nlm.nih.gov/pubmed/8759852 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416550 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416550 RefSeq WP_000058424 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000058424 STRING 511145.b2046 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2046&targetmode=cogs STRING COG2244 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2244&targetmode=cogs TCDB 2.A.66.2 http://www.tcdb.org/search/result.php?tc=2.A.66.2 UniProtKB WZXC_ECOLI http://www.uniprot.org/uniprot/WZXC_ECOLI UniProtKB-AC P77377 http://www.uniprot.org/uniprot/P77377 charge swissprot:WZXC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:WZXC_ECOLI eggNOG COG2244 http://eggnogapi.embl.de/nog_data/html/tree/COG2244 eggNOG ENOG4105PSV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105PSV epestfind swissprot:WZXC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:WZXC_ECOLI garnier swissprot:WZXC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:WZXC_ECOLI helixturnhelix swissprot:WZXC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:WZXC_ECOLI hmoment swissprot:WZXC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:WZXC_ECOLI iep swissprot:WZXC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:WZXC_ECOLI inforesidue swissprot:WZXC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:WZXC_ECOLI octanol swissprot:WZXC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:WZXC_ECOLI pepcoil swissprot:WZXC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:WZXC_ECOLI pepdigest swissprot:WZXC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:WZXC_ECOLI pepinfo swissprot:WZXC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:WZXC_ECOLI pepnet swissprot:WZXC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:WZXC_ECOLI pepstats swissprot:WZXC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:WZXC_ECOLI pepwheel swissprot:WZXC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:WZXC_ECOLI pepwindow swissprot:WZXC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:WZXC_ECOLI sigcleave swissprot:WZXC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:WZXC_ECOLI ## Database ID URL or Descriptions # BioGrid 4260582 12 # CDD cd01614 EutN_CcmL # EcoGene EG14186 eutN # FUNCTION EUTN_ECOLI May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0046336 ethanolamine catabolic process; IEA:UniProtKB-UniPathway. # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 2.40.50.220 -; 1. # INTERACTION EUTN_ECOLI P18196 minC; NbExp=3; IntAct=EBI-8767793, EBI-554060; # IntAct P0AEJ8 13 # InterPro IPR004992 EutN_CcmL # Organism EUTN_ECOLI Escherichia coli (strain K12) # PATHWAY EUTN_ECOLI Amine and polyamine degradation; ethanolamine degradation. # PATRIC 32120295 VBIEscCol129921_2550 # PDB 2HD3 X-ray; 2.40 A; A/B/C/D/E/F/G/H/I/J/K/L=1-95 # PDB 2Z9H X-ray; 2.71 A; A/B/C/D/E/F=1-95 # PIR G65020 G65020 # Pfam PF03319 EutN_CcmL # ProDom PD012510 EutN_CcmL # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EUTN_ECOLI Ethanolamine utilization protein EutN # RefSeq NP_416951 NC_000913.3 # RefSeq WP_000762196 NZ_LN832404.1 # SIMILARITY To cyanobacterial carbon dioxide concentrating mechanism protein CcmL. {ECO 0000305}. # SUPFAM SSF159133 SSF159133 # eggNOG COG4576 LUCA # eggNOG ENOG4105WVM Bacteria BLAST swissprot:EUTN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EUTN_ECOLI BioCyc ECOL316407:JW2440-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2440-MONOMER BioCyc EcoCyc:G7286-MONOMER http://biocyc.org/getid?id=EcoCyc:G7286-MONOMER COG COG4576 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4576 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3938 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3938 EcoGene EG14186 http://www.ecogene.org/geneInfo.php?eg_id=EG14186 EnsemblBacteria AAC75509 http://www.ensemblgenomes.org/id/AAC75509 EnsemblBacteria AAC75509 http://www.ensemblgenomes.org/id/AAC75509 EnsemblBacteria BAA16334 http://www.ensemblgenomes.org/id/BAA16334 EnsemblBacteria BAA16334 http://www.ensemblgenomes.org/id/BAA16334 EnsemblBacteria BAA16334 http://www.ensemblgenomes.org/id/BAA16334 EnsemblBacteria b2456 http://www.ensemblgenomes.org/id/b2456 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0046336 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046336 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 2.40.50.220 http://www.cathdb.info/version/latest/superfamily/2.40.50.220 GeneID 946945 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946945 HOGENOM HOG000287950 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000287950&db=HOGENOM6 InParanoid P0AEJ8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEJ8 IntAct P0AEJ8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEJ8* InterPro IPR004992 http://www.ebi.ac.uk/interpro/entry/IPR004992 KEGG_Gene ecj:JW2440 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2440 KEGG_Gene eco:b2456 http://www.genome.jp/dbget-bin/www_bget?eco:b2456 KEGG_Orthology KO:K04028 http://www.genome.jp/dbget-bin/www_bget?KO:K04028 OMA NIGAGCG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NIGAGCG PDB 2HD3 http://www.ebi.ac.uk/pdbe-srv/view/entry/2HD3 PDB 2Z9H http://www.ebi.ac.uk/pdbe-srv/view/entry/2Z9H PDBsum 2HD3 http://www.ebi.ac.uk/pdbsum/2HD3 PDBsum 2Z9H http://www.ebi.ac.uk/pdbsum/2Z9H PSORT swissprot:EUTN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EUTN_ECOLI PSORT-B swissprot:EUTN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EUTN_ECOLI PSORT2 swissprot:EUTN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EUTN_ECOLI Pfam PF03319 http://pfam.xfam.org/family/PF03319 Phobius swissprot:EUTN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EUTN_ECOLI PhylomeDB P0AEJ8 http://phylomedb.org/?seqid=P0AEJ8 ProteinModelPortal P0AEJ8 http://www.proteinmodelportal.org/query/uniprot/P0AEJ8 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416951 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416951 RefSeq WP_000762196 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000762196 SMR P0AEJ8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEJ8 STRING 511145.b2456 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2456&targetmode=cogs STRING COG4576 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4576&targetmode=cogs SUPFAM SSF159133 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF159133 UniProtKB EUTN_ECOLI http://www.uniprot.org/uniprot/EUTN_ECOLI UniProtKB-AC P0AEJ8 http://www.uniprot.org/uniprot/P0AEJ8 charge swissprot:EUTN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EUTN_ECOLI eggNOG COG4576 http://eggnogapi.embl.de/nog_data/html/tree/COG4576 eggNOG ENOG4105WVM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105WVM epestfind swissprot:EUTN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EUTN_ECOLI garnier swissprot:EUTN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EUTN_ECOLI helixturnhelix swissprot:EUTN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EUTN_ECOLI hmoment swissprot:EUTN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EUTN_ECOLI iep swissprot:EUTN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EUTN_ECOLI inforesidue swissprot:EUTN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EUTN_ECOLI octanol swissprot:EUTN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EUTN_ECOLI pepcoil swissprot:EUTN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EUTN_ECOLI pepdigest swissprot:EUTN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EUTN_ECOLI pepinfo swissprot:EUTN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EUTN_ECOLI pepnet swissprot:EUTN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EUTN_ECOLI pepstats swissprot:EUTN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EUTN_ECOLI pepwheel swissprot:EUTN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EUTN_ECOLI pepwindow swissprot:EUTN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EUTN_ECOLI sigcleave swissprot:EUTN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EUTN_ECOLI ## Database ID URL or Descriptions # BioGrid 4259556 215 # CATALYTIC ACTIVITY ATP + thymidine = ADP + thymidine 5'- phosphate. {ECO:0000255|HAMAP-Rule MF_00124}. # ENZYME REGULATION KITH_ECOLI Allosteric enzyme which is feedback inhibited by dTTP and activated by a number of dNDP and dNTP. # EcoGene EG10994 tdk # FUNCTION KITH_ECOLI Phosphorylates both thymidine and deoxyuridine. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004797 thymidine kinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008270 zinc ion binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006259 DNA metabolic process; IDA:EcoCyc. # GO_process GO:0046104 thymidine metabolic process; IBA:GO_Central. # GO_process GO:0071897 DNA biosynthetic process; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # HAMAP MF_00124 Thymidine_kinase # IntAct P23331 6 # InterPro IPR001267 Thymidine_kinase # InterPro IPR020633 Thymidine_kinase_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00240 Pyrimidine metabolism # KEGG_Pathway ko00983 Drug metabolism - other enzymes # Organism KITH_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11441 PTHR11441 # PATRIC 32117732 VBIEscCol129921_1286 # PIR JS0519 JS0519 # PIRSF PIRSF035805 TK_cell # PROSITE PS00603 TK_CELLULAR_TYPE # Pfam PF00265 TK # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Thymidine kinase {ECO:0000255|HAMAP-Rule MF_00124} # RefSeq NP_415754 NC_000913.3 # RefSeq WP_000068077 NZ_LN832404.1 # SIMILARITY Belongs to the thymidine kinase family. {ECO:0000255|HAMAP-Rule MF_00124}. # SUBCELLULAR LOCATION KITH_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00124}. # SUBUNIT Homotetramer. {ECO:0000255|HAMAP-Rule MF_00124}. # SUPFAM SSF52540 SSF52540 # eggNOG COG1435 LUCA # eggNOG ENOG4107104 Bacteria BLAST swissprot:KITH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:KITH_ECOLI BioCyc ECOL316407:JW1226-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1226-MONOMER BioCyc EcoCyc:TDK-MONOMER http://biocyc.org/getid?id=EcoCyc:TDK-MONOMER BioCyc MetaCyc:TDK-MONOMER http://biocyc.org/getid?id=MetaCyc:TDK-MONOMER COG COG1435 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1435 DOI 10.1016/0378-1119(91)90218-Z http://dx.doi.org/10.1016/0378-1119(91)90218-Z DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/jac/dkm240 http://dx.doi.org/10.1093/jac/dkm240 DOI 10.1099/13500872-141-4-959 http://dx.doi.org/10.1099/13500872-141-4-959 DOI 10.1111/j.1365-2958.1991.tb02119.x http://dx.doi.org/10.1111/j.1365-2958.1991.tb02119.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.21 {ECO:0000255|HAMAP-Rule:MF_00124} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.21 {ECO:0000255|HAMAP-Rule:MF_00124} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL DQ384607 http://www.ebi.ac.uk/ena/data/view/DQ384607 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X51523 http://www.ebi.ac.uk/ena/data/view/X51523 EMBL X53733 http://www.ebi.ac.uk/ena/data/view/X53733 EMBL X67326 http://www.ebi.ac.uk/ena/data/view/X67326 ENZYME 2.7.1.21 {ECO:0000255|HAMAP-Rule:MF_00124} http://enzyme.expasy.org/EC/2.7.1.21 {ECO:0000255|HAMAP-Rule:MF_00124} EchoBASE EB0987 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0987 EcoGene EG10994 http://www.ecogene.org/geneInfo.php?eg_id=EG10994 EnsemblBacteria AAC74320 http://www.ensemblgenomes.org/id/AAC74320 EnsemblBacteria AAC74320 http://www.ensemblgenomes.org/id/AAC74320 EnsemblBacteria BAA36118 http://www.ensemblgenomes.org/id/BAA36118 EnsemblBacteria BAA36118 http://www.ensemblgenomes.org/id/BAA36118 EnsemblBacteria BAA36118 http://www.ensemblgenomes.org/id/BAA36118 EnsemblBacteria b1238 http://www.ensemblgenomes.org/id/b1238 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004797 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004797 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GO_process GO:0046104 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046104 GO_process GO:0071897 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071897 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 945834 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945834 HAMAP MF_00124 http://hamap.expasy.org/unirule/MF_00124 HOGENOM HOG000076391 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000076391&db=HOGENOM6 InParanoid P23331 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23331 IntAct P23331 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P23331* IntEnz 2.7.1.21 {ECO:0000255|HAMAP-Rule:MF_00124} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.21 {ECO:0000255|HAMAP-Rule:MF_00124} InterPro IPR001267 http://www.ebi.ac.uk/interpro/entry/IPR001267 InterPro IPR020633 http://www.ebi.ac.uk/interpro/entry/IPR020633 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1226 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1226 KEGG_Gene eco:b1238 http://www.genome.jp/dbget-bin/www_bget?eco:b1238 KEGG_Orthology KO:K00857 http://www.genome.jp/dbget-bin/www_bget?KO:K00857 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Pathway ko00983 http://www.genome.jp/kegg-bin/show_pathway?ko00983 KEGG_Reaction rn:R01567 http://www.genome.jp/dbget-bin/www_bget?rn:R01567 KEGG_Reaction rn:R02099 http://www.genome.jp/dbget-bin/www_bget?rn:R02099 KEGG_Reaction rn:R08233 http://www.genome.jp/dbget-bin/www_bget?rn:R08233 OMA FFEYGAM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FFEYGAM PANTHER PTHR11441 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11441 PROSITE PS00603 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00603 PSORT swissprot:KITH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:KITH_ECOLI PSORT-B swissprot:KITH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:KITH_ECOLI PSORT2 swissprot:KITH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:KITH_ECOLI Pfam PF00265 http://pfam.xfam.org/family/PF00265 Phobius swissprot:KITH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:KITH_ECOLI PhylomeDB P23331 http://phylomedb.org/?seqid=P23331 ProteinModelPortal P23331 http://www.proteinmodelportal.org/query/uniprot/P23331 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17615154 http://www.ncbi.nlm.nih.gov/pubmed/17615154 PubMed 2041474 http://www.ncbi.nlm.nih.gov/pubmed/2041474 PubMed 2060797 http://www.ncbi.nlm.nih.gov/pubmed/2060797 PubMed 7773397 http://www.ncbi.nlm.nih.gov/pubmed/7773397 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415754 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415754 RefSeq WP_000068077 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000068077 SMR P23331 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P23331 STRING 511145.b1238 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1238&targetmode=cogs STRING COG1435 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1435&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB KITH_ECOLI http://www.uniprot.org/uniprot/KITH_ECOLI UniProtKB-AC P23331 http://www.uniprot.org/uniprot/P23331 charge swissprot:KITH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:KITH_ECOLI eggNOG COG1435 http://eggnogapi.embl.de/nog_data/html/tree/COG1435 eggNOG ENOG4107104 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107104 epestfind swissprot:KITH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:KITH_ECOLI garnier swissprot:KITH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:KITH_ECOLI helixturnhelix swissprot:KITH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:KITH_ECOLI hmoment swissprot:KITH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:KITH_ECOLI iep swissprot:KITH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:KITH_ECOLI inforesidue swissprot:KITH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:KITH_ECOLI octanol swissprot:KITH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:KITH_ECOLI pepcoil swissprot:KITH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:KITH_ECOLI pepdigest swissprot:KITH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:KITH_ECOLI pepinfo swissprot:KITH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:KITH_ECOLI pepnet swissprot:KITH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:KITH_ECOLI pepstats swissprot:KITH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:KITH_ECOLI pepwheel swissprot:KITH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:KITH_ECOLI pepwindow swissprot:KITH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:KITH_ECOLI sigcleave swissprot:KITH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:KITH_ECOLI ## Database ID URL or Descriptions # AltName SGCB_ECOLI Putative PTS system EIIB component # BioGrid 4262742 7 # CATALYTIC ACTIVITY Protein EIIB N(pi)-phospho-L- histidine/cysteine + sugar = protein EIIB + sugar phosphate. {ECO:0000255|PROSITE-ProRule PRU00422}. # DOMAIN SGCB_ECOLI The EIIB domain is phosphorylated by phospho-EIIA on a cysteinyl or histidyl residue, depending on the transported sugar. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the EIIC domain. # EcoGene EG14343 sgcB # FUNCTION SGCB_ECOLI The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. {ECO 0000250}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0008982 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:InterPro. # GO_function GO:0016301 kinase activity; IEA:UniProtKB-KW. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; ISM:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR003501 PTS_EIIB_2/3 # InterPro IPR013011 PTS_EIIB_2 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00279 PTS system, galactitol-specific II component # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko00052 Galactose metabolism # KEGG_Pathway ko02060 Phosphotransferase system (PTS) # Organism SGCB_ECOLI Escherichia coli (strain K12) # PATRIC 32124196 VBIEscCol129921_4441 # PROSITE PS51099 PTS_EIIB_TYPE_2 # Pfam PF02302 PTS_IIB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SGCB_ECOLI Putative phosphotransferase enzyme IIB component SgcB # RefSeq WP_000722973 NZ_LN832404.1 # RefSeq YP_588476 NC_000913.3 # SIMILARITY Contains 1 PTS EIIB type-2 domain. {ECO:0000255|PROSITE-ProRule PRU00422}. # SUBCELLULAR LOCATION SGCB_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF52794 SSF52794 # TCDB 4.A.5.1 the pts galactitol (gat) family # eggNOG COG3414 LUCA # eggNOG ENOG4105K18 Bacteria BLAST swissprot:SGCB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SGCB_ECOLI BioCyc ECOL316407:JW5967-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5967-MONOMER BioCyc EcoCyc:MONOMER0-2121 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2121 BioCyc MetaCyc:MONOMER0-2121 http://biocyc.org/getid?id=MetaCyc:MONOMER0-2121 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.- http://enzyme.expasy.org/EC/2.7.1.- EcoGene EG14343 http://www.ecogene.org/geneInfo.php?eg_id=EG14343 EnsemblBacteria ABD18717 http://www.ensemblgenomes.org/id/ABD18717 EnsemblBacteria ABD18717 http://www.ensemblgenomes.org/id/ABD18717 EnsemblBacteria BAE78296 http://www.ensemblgenomes.org/id/BAE78296 EnsemblBacteria BAE78296 http://www.ensemblgenomes.org/id/BAE78296 EnsemblBacteria BAE78296 http://www.ensemblgenomes.org/id/BAE78296 EnsemblBacteria b4565 http://www.ensemblgenomes.org/id/b4565 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0008982 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008982 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 1450295 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1450295 HOGENOM HOG000230475 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230475&db=HOGENOM6 IntEnz 2.7.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1 InterPro IPR003501 http://www.ebi.ac.uk/interpro/entry/IPR003501 InterPro IPR013011 http://www.ebi.ac.uk/interpro/entry/IPR013011 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5967 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5967 KEGG_Gene eco:b4565 http://www.genome.jp/dbget-bin/www_bget?eco:b4565 KEGG_Orthology KO:K02774 http://www.genome.jp/dbget-bin/www_bget?KO:K02774 KEGG_Pathway ko00052 http://www.genome.jp/kegg-bin/show_pathway?ko00052 KEGG_Pathway ko02060 http://www.genome.jp/kegg-bin/show_pathway?ko02060 KEGG_Reaction rn:R05570 http://www.genome.jp/dbget-bin/www_bget?rn:R05570 OMA PVINARS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PVINARS PROSITE PS51099 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51099 PSORT swissprot:SGCB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SGCB_ECOLI PSORT-B swissprot:SGCB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SGCB_ECOLI PSORT2 swissprot:SGCB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SGCB_ECOLI Pfam PF02302 http://pfam.xfam.org/family/PF02302 Phobius swissprot:SGCB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SGCB_ECOLI PhylomeDB P58035 http://phylomedb.org/?seqid=P58035 ProteinModelPortal P58035 http://www.proteinmodelportal.org/query/uniprot/P58035 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000722973 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000722973 RefSeq YP_588476 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_588476 SMR P58035 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P58035 STRING 511145.b4565 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4565&targetmode=cogs SUPFAM SSF52794 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52794 TCDB 4.A.5.1 http://www.tcdb.org/search/result.php?tc=4.A.5.1 UniProtKB SGCB_ECOLI http://www.uniprot.org/uniprot/SGCB_ECOLI UniProtKB-AC P58035 http://www.uniprot.org/uniprot/P58035 charge swissprot:SGCB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SGCB_ECOLI eggNOG COG3414 http://eggnogapi.embl.de/nog_data/html/tree/COG3414 eggNOG ENOG4105K18 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K18 epestfind swissprot:SGCB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SGCB_ECOLI garnier swissprot:SGCB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SGCB_ECOLI helixturnhelix swissprot:SGCB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SGCB_ECOLI hmoment swissprot:SGCB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SGCB_ECOLI iep swissprot:SGCB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SGCB_ECOLI inforesidue swissprot:SGCB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SGCB_ECOLI octanol swissprot:SGCB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SGCB_ECOLI pepcoil swissprot:SGCB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SGCB_ECOLI pepdigest swissprot:SGCB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SGCB_ECOLI pepinfo swissprot:SGCB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SGCB_ECOLI pepnet swissprot:SGCB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SGCB_ECOLI pepstats swissprot:SGCB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SGCB_ECOLI pepwheel swissprot:SGCB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SGCB_ECOLI pepwindow swissprot:SGCB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SGCB_ECOLI sigcleave swissprot:SGCB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SGCB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260331 6 # EcoGene EG13503 yeaQ # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR007341 Transgly_assoc # Organism YEAQ_ECOLI Escherichia coli (strain K12) # PATRIC 32118905 VBIEscCol129921_1870 # PIR C64940 C64940 # Pfam PF04226 Transgly_assoc # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEAQ_ECOLI UPF0410 protein YeaQ # RefSeq NP_416309 NC_000913.3 # RefSeq WP_000512153 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0410 family. {ECO 0000305}. # SUBCELLULAR LOCATION YEAQ_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # eggNOG COG2261 LUCA # eggNOG ENOG4105Y3U Bacteria BLAST swissprot:YEAQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEAQ_ECOLI BioCyc ECOL316407:JW1784-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1784-MONOMER BioCyc EcoCyc:G6981-MONOMER http://biocyc.org/getid?id=EcoCyc:G6981-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3276 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3276 EcoGene EG13503 http://www.ecogene.org/geneInfo.php?eg_id=EG13503 EnsemblBacteria AAC74865 http://www.ensemblgenomes.org/id/AAC74865 EnsemblBacteria AAC74865 http://www.ensemblgenomes.org/id/AAC74865 EnsemblBacteria BAE76531 http://www.ensemblgenomes.org/id/BAE76531 EnsemblBacteria BAE76531 http://www.ensemblgenomes.org/id/BAE76531 EnsemblBacteria BAE76531 http://www.ensemblgenomes.org/id/BAE76531 EnsemblBacteria b1795 http://www.ensemblgenomes.org/id/b1795 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 946311 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946311 HOGENOM HOG000281220 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000281220&db=HOGENOM6 InParanoid P64485 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P64485 InterPro IPR007341 http://www.ebi.ac.uk/interpro/entry/IPR007341 KEGG_Gene ecj:JW1784 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1784 KEGG_Gene eco:b1795 http://www.genome.jp/dbget-bin/www_bget?eco:b1795 OMA KWIMPGR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KWIMPGR PSORT swissprot:YEAQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEAQ_ECOLI PSORT-B swissprot:YEAQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEAQ_ECOLI PSORT2 swissprot:YEAQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEAQ_ECOLI Pfam PF04226 http://pfam.xfam.org/family/PF04226 Phobius swissprot:YEAQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEAQ_ECOLI PhylomeDB P64485 http://phylomedb.org/?seqid=P64485 ProteinModelPortal P64485 http://www.proteinmodelportal.org/query/uniprot/P64485 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416309 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416309 RefSeq WP_000512153 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000512153 STRING 511145.b1795 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1795&targetmode=cogs UniProtKB YEAQ_ECOLI http://www.uniprot.org/uniprot/YEAQ_ECOLI UniProtKB-AC P64485 http://www.uniprot.org/uniprot/P64485 charge swissprot:YEAQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEAQ_ECOLI eggNOG COG2261 http://eggnogapi.embl.de/nog_data/html/tree/COG2261 eggNOG ENOG4105Y3U http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105Y3U epestfind swissprot:YEAQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEAQ_ECOLI garnier swissprot:YEAQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEAQ_ECOLI helixturnhelix swissprot:YEAQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEAQ_ECOLI hmoment swissprot:YEAQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEAQ_ECOLI iep swissprot:YEAQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEAQ_ECOLI inforesidue swissprot:YEAQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEAQ_ECOLI octanol swissprot:YEAQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEAQ_ECOLI pepcoil swissprot:YEAQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEAQ_ECOLI pepdigest swissprot:YEAQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEAQ_ECOLI pepinfo swissprot:YEAQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEAQ_ECOLI pepnet swissprot:YEAQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEAQ_ECOLI pepstats swissprot:YEAQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEAQ_ECOLI pepwheel swissprot:YEAQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEAQ_ECOLI pepwindow swissprot:YEAQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEAQ_ECOLI sigcleave swissprot:YEAQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEAQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4262635 211 # CAUTION In contrast to PubMed:11080145, PubMed 12660153 demonstrates that OmpL actually plays no perceptible role in modulating redox potential in the periplasm of E.coli. {ECO:0000305}. # EcoGene EG13374 ompL # FUNCTION OMPL_ECOLI Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is unknown. {ECO 0000269|PubMed 12660153}. # GO_component GO:0009279 cell outer membrane; IDA:EcoliWiki. # GO_component GO:0046930 pore complex; IEA:UniProtKB-KW. # GO_function GO:0015288 porin activity; IDA:EcoCyc. # GO_process GO:0006811 ion transport; IEA:UniProtKB-KW. # GO_process GO:0015751 arabinose transport; IDA:EcoliWiki. # GO_process GO:0015757 galactose transport; IDA:EcoliWiki. # GO_process GO:0046323 glucose import; IDA:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043234 protein complex # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # IntAct P76773 21 # InterPro IPR009331 Oligogalacturonate-sp_porin # Organism OMPL_ECOLI Escherichia coli (strain K12) # PATRIC 32123253 VBIEscCol129921_3987 # PIR F65192 F65192 # Pfam PF06178 KdgM # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName OMPL_ECOLI Porin OmpL # RefSeq NP_418311 NC_000913.3 # RefSeq WP_000723465 NZ_LN832404.1 # SIMILARITY Belongs to the oligogalacturonate-specific porin KdgM (TC 1.B.35) family. OmpL subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION OMPL_ECOLI Cell outer membrane {ECO 0000269|PubMed 11080145}. # TCDB 1.B.35.2 the oligogalacturonate-specific porin (kdgm) family # eggNOG ENOG4108KUC Bacteria # eggNOG ENOG410XRD5 LUCA BLAST swissprot:OMPL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:OMPL_ECOLI BioCyc ECOL316407:JW3846-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3846-MONOMER BioCyc EcoCyc:G7814-MONOMER http://biocyc.org/getid?id=EcoCyc:G7814-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/sj.emboj.7600439 http://dx.doi.org/10.1038/sj.emboj.7600439 DOI 10.1093/emboj/19.22.5980 http://dx.doi.org/10.1093/emboj/19.22.5980 DOI 10.1093/emboj/cdg152 http://dx.doi.org/10.1093/emboj/cdg152 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3156 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3156 EcoGene EG13374 http://www.ecogene.org/geneInfo.php?eg_id=EG13374 EnsemblBacteria AAC76872 http://www.ensemblgenomes.org/id/AAC76872 EnsemblBacteria AAC76872 http://www.ensemblgenomes.org/id/AAC76872 EnsemblBacteria BAE77434 http://www.ensemblgenomes.org/id/BAE77434 EnsemblBacteria BAE77434 http://www.ensemblgenomes.org/id/BAE77434 EnsemblBacteria BAE77434 http://www.ensemblgenomes.org/id/BAE77434 EnsemblBacteria b3875 http://www.ensemblgenomes.org/id/b3875 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0046930 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046930 GO_function GO:0015288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015288 GO_process GO:0006811 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811 GO_process GO:0015751 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015751 GO_process GO:0015757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015757 GO_process GO:0046323 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046323 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948366 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948366 HOGENOM HOG000005069 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000005069&db=HOGENOM6 IntAct P76773 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76773* InterPro IPR009331 http://www.ebi.ac.uk/interpro/entry/IPR009331 KEGG_Gene ecj:JW3846 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3846 KEGG_Gene eco:b3875 http://www.genome.jp/dbget-bin/www_bget?eco:b3875 OMA WLPYLEL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WLPYLEL PSORT swissprot:OMPL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:OMPL_ECOLI PSORT-B swissprot:OMPL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:OMPL_ECOLI PSORT2 swissprot:OMPL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:OMPL_ECOLI Pfam PF06178 http://pfam.xfam.org/family/PF06178 Phobius swissprot:OMPL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:OMPL_ECOLI ProteinModelPortal P76773 http://www.proteinmodelportal.org/query/uniprot/P76773 PubMed 11080145 http://www.ncbi.nlm.nih.gov/pubmed/11080145 PubMed 12660153 http://www.ncbi.nlm.nih.gov/pubmed/12660153 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418311 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418311 RefSeq WP_000723465 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000723465 SMR P76773 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76773 STRING 511145.b3875 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3875&targetmode=cogs TCDB 1.B.35.2 http://www.tcdb.org/search/result.php?tc=1.B.35.2 UniProtKB OMPL_ECOLI http://www.uniprot.org/uniprot/OMPL_ECOLI UniProtKB-AC P76773 http://www.uniprot.org/uniprot/P76773 charge swissprot:OMPL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:OMPL_ECOLI eggNOG ENOG4108KUC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108KUC eggNOG ENOG410XRD5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRD5 epestfind swissprot:OMPL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:OMPL_ECOLI garnier swissprot:OMPL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:OMPL_ECOLI helixturnhelix swissprot:OMPL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:OMPL_ECOLI hmoment swissprot:OMPL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:OMPL_ECOLI iep swissprot:OMPL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:OMPL_ECOLI inforesidue swissprot:OMPL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:OMPL_ECOLI octanol swissprot:OMPL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:OMPL_ECOLI pepcoil swissprot:OMPL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:OMPL_ECOLI pepdigest swissprot:OMPL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:OMPL_ECOLI pepinfo swissprot:OMPL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:OMPL_ECOLI pepnet swissprot:OMPL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:OMPL_ECOLI pepstats swissprot:OMPL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:OMPL_ECOLI pepwheel swissprot:OMPL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:OMPL_ECOLI pepwindow swissprot:OMPL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:OMPL_ECOLI sigcleave swissprot:OMPL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:OMPL_ECOLI ## Database ID URL or Descriptions # BioGrid 4260111 19 # EcoGene EG12402 chaB # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # IntAct P0AE63 2 # InterPro IPR009317 ChaB # Organism CHAB_ECOLI Escherichia coli (strain K12) # PATRIC 32117692 VBIEscCol129921_1268 # PDB 1SG7 NMR; -; A=2-76 # PIR F64868 F64868 # Pfam PF06150 ChaB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CHAB_ECOLI Cation transport regulator ChaB # RefSeq NP_415735 NC_000913.3 # RefSeq WP_001146444 NZ_LN832404.1 # eggNOG COG4572 LUCA # eggNOG ENOG4105WS7 Bacteria BLAST swissprot:CHAB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CHAB_ECOLI BioCyc ECOL316407:JW1208-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1208-MONOMER BioCyc EcoCyc:EG12402-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12402-MONOMER COG COG4572 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4572 DIP DIP-47930N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47930N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L28709 http://www.ebi.ac.uk/ena/data/view/L28709 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2302 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2302 EcoGene EG12402 http://www.ecogene.org/geneInfo.php?eg_id=EG12402 EnsemblBacteria AAC74301 http://www.ensemblgenomes.org/id/AAC74301 EnsemblBacteria AAC74301 http://www.ensemblgenomes.org/id/AAC74301 EnsemblBacteria BAA36075 http://www.ensemblgenomes.org/id/BAA36075 EnsemblBacteria BAA36075 http://www.ensemblgenomes.org/id/BAA36075 EnsemblBacteria BAA36075 http://www.ensemblgenomes.org/id/BAA36075 EnsemblBacteria b1217 http://www.ensemblgenomes.org/id/b1217 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 945792 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945792 HOGENOM HOG000065001 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000065001&db=HOGENOM6 InParanoid P0AE63 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AE63 IntAct P0AE63 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AE63* InterPro IPR009317 http://www.ebi.ac.uk/interpro/entry/IPR009317 KEGG_Gene ecj:JW1208 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1208 KEGG_Gene eco:b1217 http://www.genome.jp/dbget-bin/www_bget?eco:b1217 KEGG_Orthology KO:K06197 http://www.genome.jp/dbget-bin/www_bget?KO:K06197 OMA PKHAQEI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PKHAQEI PDB 1SG7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1SG7 PDBsum 1SG7 http://www.ebi.ac.uk/pdbsum/1SG7 PSORT swissprot:CHAB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CHAB_ECOLI PSORT-B swissprot:CHAB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CHAB_ECOLI PSORT2 swissprot:CHAB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CHAB_ECOLI Pfam PF06150 http://pfam.xfam.org/family/PF06150 Phobius swissprot:CHAB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CHAB_ECOLI ProteinModelPortal P0AE63 http://www.proteinmodelportal.org/query/uniprot/P0AE63 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415735 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415735 RefSeq WP_001146444 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001146444 SMR P0AE63 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AE63 STRING 511145.b1217 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1217&targetmode=cogs STRING COG4572 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4572&targetmode=cogs UniProtKB CHAB_ECOLI http://www.uniprot.org/uniprot/CHAB_ECOLI UniProtKB-AC P0AE63 http://www.uniprot.org/uniprot/P0AE63 charge swissprot:CHAB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CHAB_ECOLI eggNOG COG4572 http://eggnogapi.embl.de/nog_data/html/tree/COG4572 eggNOG ENOG4105WS7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105WS7 epestfind swissprot:CHAB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CHAB_ECOLI garnier swissprot:CHAB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CHAB_ECOLI helixturnhelix swissprot:CHAB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CHAB_ECOLI hmoment swissprot:CHAB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CHAB_ECOLI iep swissprot:CHAB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CHAB_ECOLI inforesidue swissprot:CHAB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CHAB_ECOLI octanol swissprot:CHAB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CHAB_ECOLI pepcoil swissprot:CHAB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CHAB_ECOLI pepdigest swissprot:CHAB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CHAB_ECOLI pepinfo swissprot:CHAB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CHAB_ECOLI pepnet swissprot:CHAB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CHAB_ECOLI pepstats swissprot:CHAB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CHAB_ECOLI pepwheel swissprot:CHAB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CHAB_ECOLI pepwindow swissprot:CHAB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CHAB_ECOLI sigcleave swissprot:CHAB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CHAB_ECOLI ## Database ID URL or Descriptions # AltName GCSP_ECOLI Glycine cleavage system P-protein # AltName GCSP_ECOLI Glycine decarboxylase # AltName GCSP_ECOLI Glycine dehydrogenase (aminomethyl-transferring) # BioGrid 4259708 18 # CATALYTIC ACTIVITY GCSP_ECOLI Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO(2). # CDD cd00613 GDC-P; 2 # COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI 597326; # EcoGene EG11810 gcvP # FUNCTION GCSP_ECOLI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0005960 glycine cleavage complex; IBA:GO_Central. # GO_function GO:0004375 glycine dehydrogenase (decarboxylating) activity; IDA:EcoCyc. # GO_function GO:0016594 glycine binding; IBA:GO_Central. # GO_process GO:0019464 glycine decarboxylation via glycine cleavage system; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # Gene3D 3.40.640.10 -; 2. # HAMAP MF_00711 GcvP # INDUCTION GCSP_ECOLI By glycine. # INTERACTION GCSP_ECOLI Self; NbExp=2; IntAct=EBI-551489, EBI-551489; # IntAct P33195 14 # InterPro IPR003437 GcvP # InterPro IPR015421 PyrdxlP-dep_Trfase_major_sub1 # InterPro IPR015424 PyrdxlP-dep_Trfase # InterPro IPR020581 GDC_P # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00260 Glycine, serine and threonine metabolism # Organism GCSP_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11773 PTHR11773 # PATRIC 32121220 VBIEscCol129921_2998 # PIR S36834 S36834 # Pfam PF02347 GDC-P; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GCSP_ECOLI Glycine dehydrogenase (decarboxylating) # RefSeq NP_417379 NC_000913.3 # RefSeq WP_000195062 NZ_LN832404.1 # SIMILARITY Belongs to the GcvP family. {ECO 0000305}. # SUBUNIT The glycine cleavage system is composed of four proteins P, T, L and H. # SUPFAM SSF53383 SSF53383; 3 # TIGRFAMs TIGR00461 gcvP # eggNOG COG0403 LUCA # eggNOG COG1003 LUCA # eggNOG ENOG4105CBI Bacteria BLAST swissprot:GCSP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GCSP_ECOLI BioCyc ECOL316407:JW2871-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2871-MONOMER BioCyc EcoCyc:GCVP-MONOMER http://biocyc.org/getid?id=EcoCyc:GCVP-MONOMER BioCyc MetaCyc:GCVP-MONOMER http://biocyc.org/getid?id=MetaCyc:GCVP-MONOMER COG COG0403 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0403 COG COG1003 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1003 DIP DIP-9753N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9753N DOI 10.1016/0378-1119(94)90349-2 http://dx.doi.org/10.1016/0378-1119(94)90349-2 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1432-1033.1993.tb18172.x http://dx.doi.org/10.1111/j.1432-1033.1993.tb18172.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.4.4.2 http://www.genome.jp/dbget-bin/www_bget?EC:1.4.4.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L20872 http://www.ebi.ac.uk/ena/data/view/L20872 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EMBL X73958 http://www.ebi.ac.uk/ena/data/view/X73958 ENZYME 1.4.4.2 http://enzyme.expasy.org/EC/1.4.4.2 EchoBASE EB1758 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1758 EcoGene EG11810 http://www.ecogene.org/geneInfo.php?eg_id=EG11810 EnsemblBacteria AAC75941 http://www.ensemblgenomes.org/id/AAC75941 EnsemblBacteria AAC75941 http://www.ensemblgenomes.org/id/AAC75941 EnsemblBacteria BAE76968 http://www.ensemblgenomes.org/id/BAE76968 EnsemblBacteria BAE76968 http://www.ensemblgenomes.org/id/BAE76968 EnsemblBacteria BAE76968 http://www.ensemblgenomes.org/id/BAE76968 EnsemblBacteria b2903 http://www.ensemblgenomes.org/id/b2903 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005960 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005960 GO_function GO:0004375 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004375 GO_function GO:0016594 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016594 GO_process GO:0019464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019464 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 3.40.640.10 http://www.cathdb.info/version/latest/superfamily/3.40.640.10 GeneID 947394 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947394 HAMAP MF_00711 http://hamap.expasy.org/unirule/MF_00711 HOGENOM HOG000239369 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000239369&db=HOGENOM6 InParanoid P33195 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33195 IntAct P33195 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33195* IntEnz 1.4.4.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.4.4.2 InterPro IPR003437 http://www.ebi.ac.uk/interpro/entry/IPR003437 InterPro IPR015421 http://www.ebi.ac.uk/interpro/entry/IPR015421 InterPro IPR015424 http://www.ebi.ac.uk/interpro/entry/IPR015424 InterPro IPR020581 http://www.ebi.ac.uk/interpro/entry/IPR020581 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2871 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2871 KEGG_Gene eco:b2903 http://www.genome.jp/dbget-bin/www_bget?eco:b2903 KEGG_Orthology KO:K00281 http://www.genome.jp/dbget-bin/www_bget?KO:K00281 KEGG_Pathway ko00260 http://www.genome.jp/kegg-bin/show_pathway?ko00260 KEGG_Reaction rn:R03425 http://www.genome.jp/dbget-bin/www_bget?rn:R03425 MINT MINT-1318484 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1318484 OMA CVPMSEY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CVPMSEY PANTHER PTHR11773 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11773 PSORT swissprot:GCSP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GCSP_ECOLI PSORT-B swissprot:GCSP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GCSP_ECOLI PSORT2 swissprot:GCSP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GCSP_ECOLI Pfam PF02347 http://pfam.xfam.org/family/PF02347 Phobius swissprot:GCSP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GCSP_ECOLI PhylomeDB P33195 http://phylomedb.org/?seqid=P33195 ProteinModelPortal P33195 http://www.proteinmodelportal.org/query/uniprot/P33195 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8181752 http://www.ncbi.nlm.nih.gov/pubmed/8181752 PubMed 8375392 http://www.ncbi.nlm.nih.gov/pubmed/8375392 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417379 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417379 RefSeq WP_000195062 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000195062 SMR P33195 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33195 STRING 511145.b2903 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2903&targetmode=cogs STRING COG0403 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0403&targetmode=cogs STRING COG1003 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1003&targetmode=cogs SUPFAM SSF53383 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53383 TIGRFAMs TIGR00461 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00461 UniProtKB GCSP_ECOLI http://www.uniprot.org/uniprot/GCSP_ECOLI UniProtKB-AC P33195 http://www.uniprot.org/uniprot/P33195 charge swissprot:GCSP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GCSP_ECOLI eggNOG COG0403 http://eggnogapi.embl.de/nog_data/html/tree/COG0403 eggNOG COG1003 http://eggnogapi.embl.de/nog_data/html/tree/COG1003 eggNOG ENOG4105CBI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CBI epestfind swissprot:GCSP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GCSP_ECOLI garnier swissprot:GCSP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GCSP_ECOLI helixturnhelix swissprot:GCSP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GCSP_ECOLI hmoment swissprot:GCSP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GCSP_ECOLI iep swissprot:GCSP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GCSP_ECOLI inforesidue swissprot:GCSP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GCSP_ECOLI octanol swissprot:GCSP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GCSP_ECOLI pepcoil swissprot:GCSP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GCSP_ECOLI pepdigest swissprot:GCSP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GCSP_ECOLI pepinfo swissprot:GCSP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GCSP_ECOLI pepnet swissprot:GCSP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GCSP_ECOLI pepstats swissprot:GCSP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GCSP_ECOLI pepwheel swissprot:GCSP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GCSP_ECOLI pepwindow swissprot:GCSP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GCSP_ECOLI sigcleave swissprot:GCSP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GCSP_ECOLI ## Database ID URL or Descriptions # AltName YIBG_ECOLI ORF-A3 # BioGrid 4261669 7 # EcoGene EG11763 yibG # Gene3D 1.25.40.10 -; 1. # InterPro IPR011990 TPR-like_helical_dom # Organism YIBG_ECOLI Escherichia coli (strain K12) # PIR S47817 S47817 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIBG_ECOLI Uncharacterized protein YibG # RefSeq NP_418053 NC_000913.3 # RefSeq WP_000642478 NZ_LN832404.1 BLAST swissprot:YIBG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIBG_ECOLI BioCyc ECOL316407:JW3570-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3570-MONOMER BioCyc EcoCyc:EG11763-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11763-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19044 http://www.ebi.ac.uk/ena/data/view/L19044 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1713 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1713 EcoGene EG11763 http://www.ecogene.org/geneInfo.php?eg_id=EG11763 EnsemblBacteria AAC76620 http://www.ensemblgenomes.org/id/AAC76620 EnsemblBacteria AAC76620 http://www.ensemblgenomes.org/id/AAC76620 EnsemblBacteria BAE77697 http://www.ensemblgenomes.org/id/BAE77697 EnsemblBacteria BAE77697 http://www.ensemblgenomes.org/id/BAE77697 EnsemblBacteria BAE77697 http://www.ensemblgenomes.org/id/BAE77697 EnsemblBacteria b3596 http://www.ensemblgenomes.org/id/b3596 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 1.25.40.10 http://www.cathdb.info/version/latest/superfamily/1.25.40.10 GeneID 948111 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948111 HOGENOM HOG000050908 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000050908&db=HOGENOM6 InterPro IPR011990 http://www.ebi.ac.uk/interpro/entry/IPR011990 KEGG_Gene ecj:JW3570 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3570 KEGG_Gene eco:b3596 http://www.genome.jp/dbget-bin/www_bget?eco:b3596 OMA ASHNNIM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ASHNNIM PSORT swissprot:YIBG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIBG_ECOLI PSORT-B swissprot:YIBG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIBG_ECOLI PSORT2 swissprot:YIBG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIBG_ECOLI Phobius swissprot:YIBG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIBG_ECOLI ProteinModelPortal P32106 http://www.proteinmodelportal.org/query/uniprot/P32106 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 8387990 http://www.ncbi.nlm.nih.gov/pubmed/8387990 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418053 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418053 RefSeq WP_000642478 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000642478 STRING 511145.b3596 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3596&targetmode=cogs UniProtKB YIBG_ECOLI http://www.uniprot.org/uniprot/YIBG_ECOLI UniProtKB-AC P32106 http://www.uniprot.org/uniprot/P32106 charge swissprot:YIBG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIBG_ECOLI epestfind swissprot:YIBG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIBG_ECOLI garnier swissprot:YIBG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIBG_ECOLI helixturnhelix swissprot:YIBG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIBG_ECOLI hmoment swissprot:YIBG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIBG_ECOLI iep swissprot:YIBG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIBG_ECOLI inforesidue swissprot:YIBG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIBG_ECOLI octanol swissprot:YIBG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIBG_ECOLI pepcoil swissprot:YIBG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIBG_ECOLI pepdigest swissprot:YIBG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIBG_ECOLI pepinfo swissprot:YIBG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIBG_ECOLI pepnet swissprot:YIBG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIBG_ECOLI pepstats swissprot:YIBG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIBG_ECOLI pepwheel swissprot:YIBG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIBG_ECOLI pepwindow swissprot:YIBG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIBG_ECOLI sigcleave swissprot:YIBG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIBG_ECOLI ## Database ID URL or Descriptions # AltName Antitoxin YeeU {ECO:0000303|PubMed 22515815} # AltName CBEA_ECOLI Antitoxin CbeA # BioGrid 4261519 12 # COFACTOR CBEA_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 20696400}; Note=Binds 1 Mg(2+) ion per subunit. {ECO 0000269|PubMed 20696400}; # EcoGene EG13388 cbeA # FUNCTION CBEA_ECOLI Antitoxin component of a type IV toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of its cognate toxin CbtA (YeeV). It does not bind to the toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles; it is probably retained in the MreB and FtsZ filament bundles. The mechanism has been proposed to require intergenic DNA, in cis, between the cbeA (yeeU) and cbta (yeeV) genes (PubMed 14594833). The intergenic region was not found to be necessary in another study (PubMed 22515815). Also counteracts the morphological defects caused by overexpression of SulA and DicB on cell shape. {ECO 0000269|PubMed 14594833, ECO 0000269|PubMed 22515815}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0008092 cytoskeletal protein binding; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0051495 positive regulation of cytoskeleton organization; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0008092 cytoskeletal protein binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # INTERACTION CBEA_ECOLI P0A9A6 ftsZ; NbExp=2; IntAct=EBI-1126877, EBI-370963; P0A9X4 mreB; NbExp=2; IntAct=EBI-1126877, EBI-371008; # IntAct P76364 6 # InterPro IPR009320 YagB_YeeU_YfjZ # Organism CBEA_ECOLI Escherichia coli (strain K12) # PATRIC 32119341 VBIEscCol129921_2080 # PDB 2H28 X-ray; 2.10 A; A/B=1-122 # PIR C64965 C64965 # Pfam PF06154 CbeA_antitoxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Cytoskeleton bundling-enhancing protein CbeA {ECO 0000305} # RefSeq NP_416508 NC_000913.3 # RefSeq WP_001285584 NZ_LN832404.1 # SIMILARITY Belongs to the CbeA/YafW/YfjZ antitoxin family. {ECO 0000305}. # SUBCELLULAR LOCATION CBEA_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT CBEA_ECOLI Homodimer (Probable). Interacts with polymerized and monomeric MreB and polymerized FtsZ. {ECO 0000269|PubMed 20696400, ECO 0000269|PubMed 22515815, ECO 0000305}. # eggNOG ENOG4105MAW Bacteria # eggNOG ENOG4111V4B LUCA BLAST swissprot:CBEA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CBEA_ECOLI BioCyc ECOL316407:JW1986-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1986-MONOMER BioCyc EcoCyc:G7084-MONOMER http://biocyc.org/getid?id=EcoCyc:G7084-MONOMER DOI 10.1016/j.str.2010.04.018 http://dx.doi.org/10.1016/j.str.2010.04.018 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1111/j.1365-2958.2012.08068.x http://dx.doi.org/10.1111/j.1365-2958.2012.08068.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.185.22.6600-6608.2003 http://dx.doi.org/10.1128/JB.185.22.6600-6608.2003 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3169 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3169 EcoGene EG13388 http://www.ecogene.org/geneInfo.php?eg_id=EG13388 EnsemblBacteria AAC75065 http://www.ensemblgenomes.org/id/AAC75065 EnsemblBacteria AAC75065 http://www.ensemblgenomes.org/id/AAC75065 EnsemblBacteria BAA15827 http://www.ensemblgenomes.org/id/BAA15827 EnsemblBacteria BAA15827 http://www.ensemblgenomes.org/id/BAA15827 EnsemblBacteria BAA15827 http://www.ensemblgenomes.org/id/BAA15827 EnsemblBacteria b2004 http://www.ensemblgenomes.org/id/b2004 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0008092 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008092 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0051495 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051495 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0008092 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008092 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 946510 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946510 HOGENOM HOG000290944 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000290944&db=HOGENOM6 IntAct P76364 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76364* InterPro IPR009320 http://www.ebi.ac.uk/interpro/entry/IPR009320 KEGG_Gene ecj:JW1986 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1986 KEGG_Gene eco:b2004 http://www.genome.jp/dbget-bin/www_bget?eco:b2004 OMA KQPELML http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KQPELML PDB 2H28 http://www.ebi.ac.uk/pdbe-srv/view/entry/2H28 PDBsum 2H28 http://www.ebi.ac.uk/pdbsum/2H28 PSORT swissprot:CBEA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CBEA_ECOLI PSORT-B swissprot:CBEA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CBEA_ECOLI PSORT2 swissprot:CBEA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CBEA_ECOLI Pfam PF06154 http://pfam.xfam.org/family/PF06154 Phobius swissprot:CBEA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CBEA_ECOLI PhylomeDB P76364 http://phylomedb.org/?seqid=P76364 ProteinModelPortal P76364 http://www.proteinmodelportal.org/query/uniprot/P76364 PubMed 14594833 http://www.ncbi.nlm.nih.gov/pubmed/14594833 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20696400 http://www.ncbi.nlm.nih.gov/pubmed/20696400 PubMed 22515815 http://www.ncbi.nlm.nih.gov/pubmed/22515815 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416508 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416508 RefSeq WP_001285584 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001285584 SMR P76364 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76364 STRING 511145.b2004 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2004&targetmode=cogs UniProtKB CBEA_ECOLI http://www.uniprot.org/uniprot/CBEA_ECOLI UniProtKB-AC P76364 http://www.uniprot.org/uniprot/P76364 charge swissprot:CBEA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CBEA_ECOLI eggNOG ENOG4105MAW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105MAW eggNOG ENOG4111V4B http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111V4B epestfind swissprot:CBEA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CBEA_ECOLI garnier swissprot:CBEA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CBEA_ECOLI helixturnhelix swissprot:CBEA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CBEA_ECOLI hmoment swissprot:CBEA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CBEA_ECOLI iep swissprot:CBEA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CBEA_ECOLI inforesidue swissprot:CBEA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CBEA_ECOLI octanol swissprot:CBEA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CBEA_ECOLI pepcoil swissprot:CBEA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CBEA_ECOLI pepdigest swissprot:CBEA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CBEA_ECOLI pepinfo swissprot:CBEA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CBEA_ECOLI pepnet swissprot:CBEA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CBEA_ECOLI pepstats swissprot:CBEA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CBEA_ECOLI pepwheel swissprot:CBEA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CBEA_ECOLI pepwindow swissprot:CBEA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CBEA_ECOLI sigcleave swissprot:CBEA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CBEA_ECOLI ## Database ID URL or Descriptions # AltName MOBB_ECOLI Molybdenum cofactor biosynthesis adapter protein # AltName MOBB_ECOLI Molybdopterin-guanine dinucleotide biosynthesis protein B # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters KM=7.5 uM for GTP; Note=kcat is 0.003 min(-1) for the GTPase activity.; # BioGrid 4262618 5 # CDD cd03116 MobB # EcoGene EG11828 mobB # FUNCTION MOBB_ECOLI GTP-binding protein that is not required for the biosynthesis of Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor, and not necessary for the formation of active molybdoenzymes using this form of molybdenum cofactor. May act as an adapter protein to achieve the efficient biosynthesis and utilization of MGD. Displays a weak intrinsic GTPase activity. Is also able to bind the nucleotides ATP, TTP and GDP, but with lower affinity than GTP. {ECO 0000269|PubMed 12682065, ECO 0000269|PubMed 9219527}. # GO_function GO:0005525 GTP binding; IDA:EcoCyc. # GO_process GO:0006777 Mo-molybdopterin cofactor biosynthetic process; IEA:UniProtKB-KW. # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.300 -; 1. # INDUCTION Is expressed at very low levels under both aerobic and anaerobic growth conditions. {ECO:0000269|PubMed 7551035}. # IntAct P32125 4 # InterPro IPR004435 MobB_dom # InterPro IPR027417 P-loop_NTPase # Organism MOBB_ECOLI Escherichia coli (strain K12) # PATRIC 32123209 VBIEscCol129921_3965 # PDB 1NP6 X-ray; 1.90 A; A/B=2-175 # PDB 1P9N X-ray; 2.80 A; A/B=6-175 # PIR S40802 S40802 # Pfam PF03205 MobB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MOBB_ECOLI Molybdopterin-guanine dinucleotide biosynthesis adapter protein # RefSeq NP_418293 NC_000913.3 # RefSeq WP_000907622 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB02991.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAE77452.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the MobB family. {ECO 0000305}. # SUBUNIT MOBB_ECOLI Homodimer. Interacts with MobA, MogA and MoeA in vivo. {ECO 0000269|PubMed 12372836, ECO 0000269|PubMed 12682065, ECO 0000269|PubMed 14646116, ECO 0000269|PubMed 9219527}. # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR00176 mobB # eggNOG COG1763 LUCA # eggNOG ENOG4105FNP Bacteria BLAST swissprot:MOBB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MOBB_ECOLI BioCyc ECOL316407:JW5575-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5575-MONOMER BioCyc EcoCyc:EG11828-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11828-MONOMER COG COG1763 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1763 DIP DIP-10234N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10234N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M007407200 http://dx.doi.org/10.1074/jbc.M007407200 DOI 10.1074/jbc.M205806200 http://dx.doi.org/10.1074/jbc.M205806200 DOI 10.1074/jbc.M301485200 http://dx.doi.org/10.1074/jbc.M301485200 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1099/13500872-141-7-1663 http://dx.doi.org/10.1099/13500872-141-7-1663 DOI 10.1107/S090744490301967X http://dx.doi.org/10.1107/S090744490301967X DOI 10.1111/j.1432-1033.1997.t01-1-00690.x http://dx.doi.org/10.1111/j.1432-1033.1997.t01-1-00690.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1775 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1775 EcoGene EG11828 http://www.ecogene.org/geneInfo.php?eg_id=EG11828 EnsemblBacteria AAC76854 http://www.ensemblgenomes.org/id/AAC76854 EnsemblBacteria AAC76854 http://www.ensemblgenomes.org/id/AAC76854 EnsemblBacteria BAE77452 http://www.ensemblgenomes.org/id/BAE77452 EnsemblBacteria BAE77452 http://www.ensemblgenomes.org/id/BAE77452 EnsemblBacteria BAE77452 http://www.ensemblgenomes.org/id/BAE77452 EnsemblBacteria b3856 http://www.ensemblgenomes.org/id/b3856 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_process GO:0006777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006777 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948343 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948343 HOGENOM HOG000280765 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000280765&db=HOGENOM6 InParanoid P32125 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32125 IntAct P32125 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32125* InterPro IPR004435 http://www.ebi.ac.uk/interpro/entry/IPR004435 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Gene ecj:JW5575 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5575 KEGG_Gene eco:b3856 http://www.genome.jp/dbget-bin/www_bget?eco:b3856 KEGG_Orthology KO:K03753 http://www.genome.jp/dbget-bin/www_bget?KO:K03753 MINT MINT-1264474 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1264474 OMA HTHHNMD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HTHHNMD PDB 1NP6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1NP6 PDB 1P9N http://www.ebi.ac.uk/pdbe-srv/view/entry/1P9N PDBsum 1NP6 http://www.ebi.ac.uk/pdbsum/1NP6 PDBsum 1P9N http://www.ebi.ac.uk/pdbsum/1P9N PSORT swissprot:MOBB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MOBB_ECOLI PSORT-B swissprot:MOBB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MOBB_ECOLI PSORT2 swissprot:MOBB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MOBB_ECOLI Pfam PF03205 http://pfam.xfam.org/family/PF03205 Phobius swissprot:MOBB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MOBB_ECOLI PhylomeDB P32125 http://phylomedb.org/?seqid=P32125 ProteinModelPortal P32125 http://www.proteinmodelportal.org/query/uniprot/P32125 PubMed 10978348 http://www.ncbi.nlm.nih.gov/pubmed/10978348 PubMed 12372836 http://www.ncbi.nlm.nih.gov/pubmed/12372836 PubMed 12682065 http://www.ncbi.nlm.nih.gov/pubmed/12682065 PubMed 14646116 http://www.ncbi.nlm.nih.gov/pubmed/14646116 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7551035 http://www.ncbi.nlm.nih.gov/pubmed/7551035 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9219527 http://www.ncbi.nlm.nih.gov/pubmed/9219527 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418293 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418293 RefSeq WP_000907622 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000907622 SMR P32125 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32125 STRING 511145.b3856 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3856&targetmode=cogs STRING COG1763 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1763&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR00176 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00176 UniProtKB MOBB_ECOLI http://www.uniprot.org/uniprot/MOBB_ECOLI UniProtKB-AC P32125 http://www.uniprot.org/uniprot/P32125 charge swissprot:MOBB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MOBB_ECOLI eggNOG COG1763 http://eggnogapi.embl.de/nog_data/html/tree/COG1763 eggNOG ENOG4105FNP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FNP epestfind swissprot:MOBB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MOBB_ECOLI garnier swissprot:MOBB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MOBB_ECOLI helixturnhelix swissprot:MOBB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MOBB_ECOLI hmoment swissprot:MOBB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MOBB_ECOLI iep swissprot:MOBB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MOBB_ECOLI inforesidue swissprot:MOBB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MOBB_ECOLI octanol swissprot:MOBB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MOBB_ECOLI pepcoil swissprot:MOBB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MOBB_ECOLI pepdigest swissprot:MOBB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MOBB_ECOLI pepinfo swissprot:MOBB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MOBB_ECOLI pepnet swissprot:MOBB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MOBB_ECOLI pepstats swissprot:MOBB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MOBB_ECOLI pepwheel swissprot:MOBB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MOBB_ECOLI pepwindow swissprot:MOBB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MOBB_ECOLI sigcleave swissprot:MOBB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MOBB_ECOLI ## Database ID URL or Descriptions # AltName VIAA_ECOLI VWA domain protein interacting with AAA ATPase # BioGrid 4261397 389 # EcoGene EG11730 viaA # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:EcoCyc. # GO_process GO:0032781 positive regulation of ATPase activity; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_process GO:0008150 biological_process # HAMAP MF_01626 ViaA # IntAct P0ADN0 5 # InterPro IPR002035 VWF_A # InterPro IPR008912 Uncharacterised_CoxE # InterPro IPR023481 Uncharacterised_ViaA # Organism VIAA_ECOLI Escherichia coli (strain K12) # PATRIC 32122989 VBIEscCol129921_3870 # PIR B65178 QQECO3 # Pfam PF05762 VWA_CoxE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName VIAA_ECOLI Protein ViaA # RefSeq WP_000956642 NZ_CP014272.1 # RefSeq YP_026243 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA62097.1; Type=Frameshift; Positions=57, 167; Evidence={ECO:0000305}; Sequence=AAA62098.1; Type=Frameshift; Positions=57, 167; Evidence={ECO 0000305}; Sequence=V00263; Type=Frameshift; Positions=476; Evidence={ECO:0000305}; # SIMILARITY Belongs to the ViaA family. {ECO 0000305}. # SMART SM00327 VWA # SUBUNIT VIAA_ECOLI Possible formation of a ternary complex RavA-ViaA-CadA. # SUPFAM SSF53300 SSF53300 # eggNOG COG2425 LUCA # eggNOG ENOG4105EV2 Bacteria BLAST swissprot:VIAA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:VIAA_ECOLI BioCyc ECOL316407:JW5610-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5610-MONOMER BioCyc EcoCyc:EG11730-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11730-MONOMER DIP DIP-47951N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47951N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1016/0378-1119(83)90087-2 http://dx.doi.org/10.1016/0378-1119(83)90087-2 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M511172200 http://dx.doi.org/10.1074/jbc.M511172200 DOI 10.1093/nar/9.18.4669 http://dx.doi.org/10.1093/nar/9.18.4669 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K00826 http://www.ebi.ac.uk/ena/data/view/K00826 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00263 http://www.ebi.ac.uk/ena/data/view/V00263 EchoBASE EB1681 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1681 EcoGene EG11730 http://www.ecogene.org/geneInfo.php?eg_id=EG11730 EnsemblBacteria AAT48203 http://www.ensemblgenomes.org/id/AAT48203 EnsemblBacteria AAT48203 http://www.ensemblgenomes.org/id/AAT48203 EnsemblBacteria BAE77543 http://www.ensemblgenomes.org/id/BAE77543 EnsemblBacteria BAE77543 http://www.ensemblgenomes.org/id/BAE77543 EnsemblBacteria BAE77543 http://www.ensemblgenomes.org/id/BAE77543 EnsemblBacteria b3745 http://www.ensemblgenomes.org/id/b3745 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_process GO:0032781 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032781 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 948257 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948257 HAMAP MF_01626 http://hamap.expasy.org/unirule/MF_01626 HOGENOM HOG000272040 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000272040&db=HOGENOM6 InParanoid P0ADN0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADN0 IntAct P0ADN0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADN0* InterPro IPR002035 http://www.ebi.ac.uk/interpro/entry/IPR002035 InterPro IPR008912 http://www.ebi.ac.uk/interpro/entry/IPR008912 InterPro IPR023481 http://www.ebi.ac.uk/interpro/entry/IPR023481 KEGG_Gene ecj:JW5610 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5610 KEGG_Gene eco:b3745 http://www.genome.jp/dbget-bin/www_bget?eco:b3745 MINT MINT-1247356 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1247356 OMA GIHQSDD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GIHQSDD PSORT swissprot:VIAA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:VIAA_ECOLI PSORT-B swissprot:VIAA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:VIAA_ECOLI PSORT2 swissprot:VIAA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:VIAA_ECOLI Pfam PF05762 http://pfam.xfam.org/family/PF05762 Phobius swissprot:VIAA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:VIAA_ECOLI PhylomeDB P0ADN0 http://phylomedb.org/?seqid=P0ADN0 ProteinModelPortal P0ADN0 http://www.proteinmodelportal.org/query/uniprot/P0ADN0 PubMed 16301313 http://www.ncbi.nlm.nih.gov/pubmed/16301313 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6117826 http://www.ncbi.nlm.nih.gov/pubmed/6117826 PubMed 6357950 http://www.ncbi.nlm.nih.gov/pubmed/6357950 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000956642 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000956642 RefSeq YP_026243 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026243 SMART SM00327 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00327 SMR P0ADN0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADN0 STRING 511145.b3745 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3745&targetmode=cogs SUPFAM SSF53300 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53300 UniProtKB VIAA_ECOLI http://www.uniprot.org/uniprot/VIAA_ECOLI UniProtKB-AC P0ADN0 http://www.uniprot.org/uniprot/P0ADN0 charge swissprot:VIAA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:VIAA_ECOLI eggNOG COG2425 http://eggnogapi.embl.de/nog_data/html/tree/COG2425 eggNOG ENOG4105EV2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EV2 epestfind swissprot:VIAA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:VIAA_ECOLI garnier swissprot:VIAA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:VIAA_ECOLI helixturnhelix swissprot:VIAA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:VIAA_ECOLI hmoment swissprot:VIAA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:VIAA_ECOLI iep swissprot:VIAA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:VIAA_ECOLI inforesidue swissprot:VIAA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:VIAA_ECOLI octanol swissprot:VIAA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:VIAA_ECOLI pepcoil swissprot:VIAA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:VIAA_ECOLI pepdigest swissprot:VIAA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:VIAA_ECOLI pepinfo swissprot:VIAA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:VIAA_ECOLI pepnet swissprot:VIAA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:VIAA_ECOLI pepstats swissprot:VIAA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:VIAA_ECOLI pepwheel swissprot:VIAA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:VIAA_ECOLI pepwindow swissprot:VIAA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:VIAA_ECOLI sigcleave swissprot:VIAA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:VIAA_ECOLI ## Database ID URL or Descriptions # BioGrid 4263116 175 # CATALYTIC ACTIVITY HOLB_ECOLI Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). # EcoGene EG11500 holB # FUNCTION HOLB_ECOLI DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. # GO_component GO:0009360 DNA polymerase III complex; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_function GO:0003887 DNA-directed DNA polymerase activity; IEA:UniProtKB-KW. # GO_function GO:0008408 3'-5' exonuclease activity; IEA:InterPro. # GO_process GO:0006261 DNA-dependent DNA replication; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004518 nuclease activity # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.300 -; 1. # INTERACTION HOLB_ECOLI P06710 dnaX; NbExp=17; IntAct=EBI-549161, EBI-549140; P06710-1 dnaX; NbExp=6; IntAct=EBI-549161, EBI-6464728; P28630 holA; NbExp=17; IntAct=EBI-549161, EBI-549153; P28905 holC; NbExp=5; IntAct=EBI-549161, EBI-549169; P23367 mutL; NbExp=2; IntAct=EBI-549161, EBI-554913; # IntAct P28631 25 # InterPro IPR004622 DNA_pol_HolB # InterPro IPR008921 DNA_pol3_clamp-load_cplx_C # InterPro IPR015199 DNA_pol_III_delta_C # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03032 DNA replication proteins # KEGG_Brite ko03032 M00260 DNA polymerase III complex, bacteria # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Brite ko03400 M00260 DNA polymerase III complex, bacteria # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00240 Pyrimidine metabolism # KEGG_Pathway ko03030 DNA replication # KEGG_Pathway ko03430 Mismatch repair # KEGG_Pathway ko03440 Homologous recombination # Organism HOLB_ECOLI Escherichia coli (strain K12) # PATRIC 32117439 VBIEscCol129921_1142 # PDB 1A5T X-ray; 2.20 A; A=1-334 # PDB 1JR3 X-ray; 2.70 A; E=1-334 # PDB 1XXH X-ray; 3.45 A; E/J=1-334 # PDB 1XXI X-ray; 4.10 A; E/J=1-334 # PDB 3GLF X-ray; 3.39 A; E/J=1-334 # PDB 3GLG X-ray; 3.25 A; E/J=1-334 # PDB 3GLH X-ray; 3.89 A; E/J/O=1-334 # PDB 3GLI X-ray; 3.50 A; E/J=1-334 # PIR S35523 S35523 # Pfam PF09115 DNApol3-delta_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HOLB_ECOLI DNA polymerase III subunit delta' # RefSeq NP_415617 NC_000913.3 # RefSeq WP_001267956 NZ_LN832404.1 # SUBUNIT The DNA polymerase holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential subassemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core (subunits alpha,epsilon and theta) contains the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork. This complex contains delta, delta', psi and chi, and copies of either or both of two different DnaX proteins, gamma and tau. The composition of the holoenzyme is, therefore (alpha,epsilon,theta)[2]-(gamma/tau)[3]-delta,delta', psi,chi- beta[4]. # SUPFAM SSF48019 SSF48019 # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR00678 holB # eggNOG COG0470 LUCA # eggNOG ENOG4107QRG Bacteria BLAST swissprot:HOLB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HOLB_ECOLI BioCyc ECOL316407:JW1085-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1085-MONOMER BioCyc EcoCyc:EG11500-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11500-MONOMER BioCyc MetaCyc:EG11500-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11500-MONOMER COG COG0470 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0470 DIP DIP-9932N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9932N DOI 10.1002/bies.950140206 http://dx.doi.org/10.1002/bies.950140206 DOI 10.1016/S0092-8674(00)80417-1 http://dx.doi.org/10.1016/S0092-8674(00)80417-1 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.7.7 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.7 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L01483 http://www.ebi.ac.uk/ena/data/view/L01483 EMBL L04577 http://www.ebi.ac.uk/ena/data/view/L04577 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.7.7 http://enzyme.expasy.org/EC/2.7.7.7 EchoBASE EB1463 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1463 EcoGene EG11500 http://www.ecogene.org/geneInfo.php?eg_id=EG11500 EnsemblBacteria AAC74183 http://www.ensemblgenomes.org/id/AAC74183 EnsemblBacteria AAC74183 http://www.ensemblgenomes.org/id/AAC74183 EnsemblBacteria BAA35906 http://www.ensemblgenomes.org/id/BAA35906 EnsemblBacteria BAA35906 http://www.ensemblgenomes.org/id/BAA35906 EnsemblBacteria BAA35906 http://www.ensemblgenomes.org/id/BAA35906 EnsemblBacteria b1099 http://www.ensemblgenomes.org/id/b1099 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009360 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003887 GO_function GO:0008408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008408 GO_process GO:0006261 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006261 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945661 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945661 HOGENOM HOG000192595 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000192595&db=HOGENOM6 InParanoid P28631 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P28631 IntAct P28631 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P28631* IntEnz 2.7.7.7 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.7 InterPro IPR004622 http://www.ebi.ac.uk/interpro/entry/IPR004622 InterPro IPR008921 http://www.ebi.ac.uk/interpro/entry/IPR008921 InterPro IPR015199 http://www.ebi.ac.uk/interpro/entry/IPR015199 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03032 http://www.genome.jp/dbget-bin/www_bget?ko03032 KEGG_Brite ko03032 http://www.genome.jp/dbget-bin/www_bget?ko03032 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW1085 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1085 KEGG_Gene eco:b1099 http://www.genome.jp/dbget-bin/www_bget?eco:b1099 KEGG_Orthology KO:K02341 http://www.genome.jp/dbget-bin/www_bget?KO:K02341 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Pathway ko03030 http://www.genome.jp/kegg-bin/show_pathway?ko03030 KEGG_Pathway ko03430 http://www.genome.jp/kegg-bin/show_pathway?ko03430 KEGG_Pathway ko03440 http://www.genome.jp/kegg-bin/show_pathway?ko03440 KEGG_Reaction rn:R00375 http://www.genome.jp/dbget-bin/www_bget?rn:R00375 KEGG_Reaction rn:R00376 http://www.genome.jp/dbget-bin/www_bget?rn:R00376 KEGG_Reaction rn:R00377 http://www.genome.jp/dbget-bin/www_bget?rn:R00377 KEGG_Reaction rn:R00378 http://www.genome.jp/dbget-bin/www_bget?rn:R00378 MINT MINT-1239429 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1239429 OMA CHSCHLM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CHSCHLM PDB 1A5T http://www.ebi.ac.uk/pdbe-srv/view/entry/1A5T PDB 1JR3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1JR3 PDB 1XXH http://www.ebi.ac.uk/pdbe-srv/view/entry/1XXH PDB 1XXI http://www.ebi.ac.uk/pdbe-srv/view/entry/1XXI PDB 3GLF http://www.ebi.ac.uk/pdbe-srv/view/entry/3GLF PDB 3GLG http://www.ebi.ac.uk/pdbe-srv/view/entry/3GLG PDB 3GLH http://www.ebi.ac.uk/pdbe-srv/view/entry/3GLH PDB 3GLI http://www.ebi.ac.uk/pdbe-srv/view/entry/3GLI PDBsum 1A5T http://www.ebi.ac.uk/pdbsum/1A5T PDBsum 1JR3 http://www.ebi.ac.uk/pdbsum/1JR3 PDBsum 1XXH http://www.ebi.ac.uk/pdbsum/1XXH PDBsum 1XXI http://www.ebi.ac.uk/pdbsum/1XXI PDBsum 3GLF http://www.ebi.ac.uk/pdbsum/3GLF PDBsum 3GLG http://www.ebi.ac.uk/pdbsum/3GLG PDBsum 3GLH http://www.ebi.ac.uk/pdbsum/3GLH PDBsum 3GLI http://www.ebi.ac.uk/pdbsum/3GLI PSORT swissprot:HOLB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HOLB_ECOLI PSORT-B swissprot:HOLB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HOLB_ECOLI PSORT2 swissprot:HOLB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HOLB_ECOLI Pfam PF09115 http://pfam.xfam.org/family/PF09115 Phobius swissprot:HOLB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HOLB_ECOLI PhylomeDB P28631 http://phylomedb.org/?seqid=P28631 ProteinModelPortal P28631 http://www.proteinmodelportal.org/query/uniprot/P28631 PubMed 1575709 http://www.ncbi.nlm.nih.gov/pubmed/1575709 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8505303 http://www.ncbi.nlm.nih.gov/pubmed/8505303 PubMed 8505304 http://www.ncbi.nlm.nih.gov/pubmed/8505304 PubMed 8509334 http://www.ncbi.nlm.nih.gov/pubmed/8509334 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9363942 http://www.ncbi.nlm.nih.gov/pubmed/9363942 RefSeq NP_415617 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415617 RefSeq WP_001267956 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001267956 SMR P28631 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P28631 STRING 511145.b1099 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1099&targetmode=cogs STRING COG0470 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0470&targetmode=cogs SUPFAM SSF48019 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48019 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR00678 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00678 UniProtKB HOLB_ECOLI http://www.uniprot.org/uniprot/HOLB_ECOLI UniProtKB-AC P28631 http://www.uniprot.org/uniprot/P28631 charge swissprot:HOLB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HOLB_ECOLI eggNOG COG0470 http://eggnogapi.embl.de/nog_data/html/tree/COG0470 eggNOG ENOG4107QRG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QRG epestfind swissprot:HOLB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HOLB_ECOLI garnier swissprot:HOLB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HOLB_ECOLI helixturnhelix swissprot:HOLB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HOLB_ECOLI hmoment swissprot:HOLB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HOLB_ECOLI iep swissprot:HOLB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HOLB_ECOLI inforesidue swissprot:HOLB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HOLB_ECOLI octanol swissprot:HOLB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HOLB_ECOLI pepcoil swissprot:HOLB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HOLB_ECOLI pepdigest swissprot:HOLB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HOLB_ECOLI pepinfo swissprot:HOLB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HOLB_ECOLI pepnet swissprot:HOLB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HOLB_ECOLI pepstats swissprot:HOLB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HOLB_ECOLI pepwheel swissprot:HOLB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HOLB_ECOLI pepwindow swissprot:HOLB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HOLB_ECOLI sigcleave swissprot:HOLB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HOLB_ECOLI ## Database ID URL or Descriptions # AltName UXUA_ECOLI D-mannonate hydro-lyase # BIOPHYSICOCHEMICAL PROPERTIES pH dependence: Optimum pH is about 7.5. The activity at pH 6.5 and 8.6 is only about 20% of the maximal achievable activity at optimum pH. {ECO 0000269|PubMed:3038546}; # BioGrid 4261003 10 # CATALYTIC ACTIVITY D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H(2)O. {ECO:0000269|PubMed 3038546}. # COFACTOR UXUA_ECOLI Name=Fe(2+); Xref=ChEBI CHEBI 29033; Evidence={ECO 0000269|PubMed 3038546}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 3038546}; Note=Mn(2+) can substitute for iron, but in higher concentrations. Cannot use Fe(3+), Ni(2+) or Mg(2+). {ECO 0000269|PubMed 3038546}; # ENZYME REGULATION Is inhibited by high concentrations of Fe(2+) (> 2 mM), and by EDTA or other iron chelators in vitro. {ECO:0000269|PubMed 3038546}. # EcoGene EG11066 uxuA # FUNCTION UXUA_ECOLI Catalyzes the dehydration of D-mannonate. {ECO 0000269|PubMed 3038546}. # GO_function GO:0008198 ferrous iron binding; IDA:EcoCyc. # GO_function GO:0008927 mannonate dehydratase activity; IMP:CACAO. # GO_function GO:0030145 manganese ion binding; IDA:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0042840 D-glucuronate catabolic process; IMP:EcoCyc. # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.150 -; 1. # HAMAP MF_00106 UxuA # INDUCTION UXUA_ECOLI By fructuronate. Its expression is subjected to catabolite repression by glucose. # IntAct P24215 2 # InterPro IPR004628 Man_deHydtase # InterPro IPR013022 Xyl_isomerase-like_TIM-brl # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00040 Pentose and glucuronate interconversions # Organism UXUA_ECOLI Escherichia coli (strain K12) # PATHWAY UXUA_ECOLI Carbohydrate metabolism; pentose and glucuronate interconversion. # PATRIC 32124240 VBIEscCol129921_4463 # PDB 4EAC X-ray; 2.30 A; A/B/C/D=1-394 # PDB 4EAY X-ray; 2.35 A; A/B/C/D=1-394 # PIR I57745 I57745 # PIR S56547 S56547 # PIRSF PIRSF016049 Man_dehyd # Pfam PF03786 UxuA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UXUA_ECOLI Mannonate dehydratase # RefSeq NP_418742 NC_000913.3 # RefSeq WP_000438562 NZ_LN832404.1 # SIMILARITY Belongs to the mannonate dehydratase family. {ECO 0000305}. # SUPFAM SSF51658 SSF51658; 2 # TIGRFAMs TIGR00695 uxuA # eggNOG COG1312 LUCA # eggNOG ENOG4105CHZ Bacteria BLAST swissprot:UXUA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UXUA_ECOLI BioCyc ECOL316407:JW4285-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4285-MONOMER BioCyc EcoCyc:MANNONDEHYDRAT-MONOMER http://biocyc.org/getid?id=EcoCyc:MANNONDEHYDRAT-MONOMER BioCyc MetaCyc:MANNONDEHYDRAT-MONOMER http://biocyc.org/getid?id=MetaCyc:MANNONDEHYDRAT-MONOMER COG COG1312 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1312 DIP DIP-11108N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11108N DOI 10.1007/BF00330526 http://dx.doi.org/10.1007/BF00330526 DOI 10.1016/S0923-2508(98)80002-8 http://dx.doi.org/10.1016/S0923-2508(98)80002-8 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1111/j.1432-1033.1987.tb13559.x http://dx.doi.org/10.1111/j.1432-1033.1987.tb13559.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.1.8 http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.8 EMBL AJ225176 http://www.ebi.ac.uk/ena/data/view/AJ225176 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D13329 http://www.ebi.ac.uk/ena/data/view/D13329 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X03411 http://www.ebi.ac.uk/ena/data/view/X03411 EMBL X91735 http://www.ebi.ac.uk/ena/data/view/X91735 ENZYME 4.2.1.8 http://enzyme.expasy.org/EC/4.2.1.8 EchoBASE EB1059 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1059 EcoGene EG11066 http://www.ecogene.org/geneInfo.php?eg_id=EG11066 EnsemblBacteria AAC77278 http://www.ensemblgenomes.org/id/AAC77278 EnsemblBacteria AAC77278 http://www.ensemblgenomes.org/id/AAC77278 EnsemblBacteria BAE78315 http://www.ensemblgenomes.org/id/BAE78315 EnsemblBacteria BAE78315 http://www.ensemblgenomes.org/id/BAE78315 EnsemblBacteria BAE78315 http://www.ensemblgenomes.org/id/BAE78315 EnsemblBacteria b4322 http://www.ensemblgenomes.org/id/b4322 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008198 GO_function GO:0008927 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008927 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0042840 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042840 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.150 http://www.cathdb.info/version/latest/superfamily/3.20.20.150 GeneID 947082 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947082 HAMAP MF_00106 http://hamap.expasy.org/unirule/MF_00106 HOGENOM HOG000195381 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000195381&db=HOGENOM6 InParanoid P24215 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P24215 IntAct P24215 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P24215* IntEnz 4.2.1.8 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.8 InterPro IPR004628 http://www.ebi.ac.uk/interpro/entry/IPR004628 InterPro IPR013022 http://www.ebi.ac.uk/interpro/entry/IPR013022 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4285 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4285 KEGG_Gene eco:b4322 http://www.genome.jp/dbget-bin/www_bget?eco:b4322 KEGG_Orthology KO:K01686 http://www.genome.jp/dbget-bin/www_bget?KO:K01686 KEGG_Pathway ko00040 http://www.genome.jp/kegg-bin/show_pathway?ko00040 KEGG_Reaction rn:R05606 http://www.genome.jp/dbget-bin/www_bget?rn:R05606 OMA EGDVDMY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EGDVDMY PDB 4EAC http://www.ebi.ac.uk/pdbe-srv/view/entry/4EAC PDB 4EAY http://www.ebi.ac.uk/pdbe-srv/view/entry/4EAY PDBsum 4EAC http://www.ebi.ac.uk/pdbsum/4EAC PDBsum 4EAY http://www.ebi.ac.uk/pdbsum/4EAY PSORT swissprot:UXUA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UXUA_ECOLI PSORT-B swissprot:UXUA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UXUA_ECOLI PSORT2 swissprot:UXUA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UXUA_ECOLI Pfam PF03786 http://pfam.xfam.org/family/PF03786 Phobius swissprot:UXUA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UXUA_ECOLI PhylomeDB P24215 http://phylomedb.org/?seqid=P24215 ProteinModelPortal P24215 http://www.proteinmodelportal.org/query/uniprot/P24215 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3038546 http://www.ncbi.nlm.nih.gov/pubmed/3038546 PubMed 3083215 http://www.ncbi.nlm.nih.gov/pubmed/3083215 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8550444 http://www.ncbi.nlm.nih.gov/pubmed/8550444 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9766199 http://www.ncbi.nlm.nih.gov/pubmed/9766199 RefSeq NP_418742 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418742 RefSeq WP_000438562 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000438562 SMR P24215 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P24215 STRING 511145.b4322 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4322&targetmode=cogs STRING COG1312 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1312&targetmode=cogs SUPFAM SSF51658 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51658 TIGRFAMs TIGR00695 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00695 UniProtKB UXUA_ECOLI http://www.uniprot.org/uniprot/UXUA_ECOLI UniProtKB-AC P24215 http://www.uniprot.org/uniprot/P24215 charge swissprot:UXUA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UXUA_ECOLI eggNOG COG1312 http://eggnogapi.embl.de/nog_data/html/tree/COG1312 eggNOG ENOG4105CHZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CHZ epestfind swissprot:UXUA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UXUA_ECOLI garnier swissprot:UXUA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UXUA_ECOLI helixturnhelix swissprot:UXUA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UXUA_ECOLI hmoment swissprot:UXUA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UXUA_ECOLI iep swissprot:UXUA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UXUA_ECOLI inforesidue swissprot:UXUA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UXUA_ECOLI octanol swissprot:UXUA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UXUA_ECOLI pepcoil swissprot:UXUA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UXUA_ECOLI pepdigest swissprot:UXUA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UXUA_ECOLI pepinfo swissprot:UXUA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UXUA_ECOLI pepnet swissprot:UXUA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UXUA_ECOLI pepstats swissprot:UXUA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UXUA_ECOLI pepwheel swissprot:UXUA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UXUA_ECOLI pepwindow swissprot:UXUA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UXUA_ECOLI sigcleave swissprot:UXUA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UXUA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262592 20 # EcoGene EG11276 tnaL # FUNCTION LPTN_ECOLI Required for tryptophan-regulated expression of the tna operon. In the presence of free L-Trp release of this nascent peptide by release factor 2 is inhibited and the ribosome stalls with the last amino acid in the P site and a UGA stop codon in the A site. This prevent transcripiton termination factor Rho binding, and thus allows transcription and translation of TnaA and TnaB. {ECO 0000269|PubMed 12228716}. # GO_process GO:0006569 tryptophan catabolic process; IMP:EcoCyc. # GO_process GO:0031556 transcriptional attenuation by ribosome; IDA:EcoCyc. # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # InterPro IPR012620 Trp_operon_leader_peptide # Organism LPTN_ECOLI Escherichia coli (strain K12) # PDB 4UY8 EM; 3.80 A; 7=5-24 # PIR I54862 I54862 # Pfam PF08053 Tna_leader # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LPTN_ECOLI Tryptophanase leader peptide # RefSeq NP_418163 NC_000913.3 # RefSeq WP_001364348 NZ_LN832404.1 # TIGRFAMs TIGR02616 tnaC_leader BLAST swissprot:LPTN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LPTN_ECOLI BioCyc ECOL316407:JW3685-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3685-MONOMER BioCyc EcoCyc:EG11276-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11276-MONOMER DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1016/j.celrep.2014.09.011 http://dx.doi.org/10.1016/j.celrep.2014.09.011 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1073997 http://dx.doi.org/10.1126/science.1073997 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M11990 http://www.ebi.ac.uk/ena/data/view/M11990 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1254 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1254 EcoGene EG11276 http://www.ecogene.org/geneInfo.php?eg_id=EG11276 EnsemblBacteria AAC76730 http://www.ensemblgenomes.org/id/AAC76730 EnsemblBacteria AAC76730 http://www.ensemblgenomes.org/id/AAC76730 EnsemblBacteria BAE77586 http://www.ensemblgenomes.org/id/BAE77586 EnsemblBacteria BAE77586 http://www.ensemblgenomes.org/id/BAE77586 EnsemblBacteria BAE77586 http://www.ensemblgenomes.org/id/BAE77586 EnsemblBacteria b3707 http://www.ensemblgenomes.org/id/b3707 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006569 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006569 GO_process GO:0031556 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031556 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 948223 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948223 InterPro IPR012620 http://www.ebi.ac.uk/interpro/entry/IPR012620 KEGG_Gene ecj:JW3685 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3685 KEGG_Gene eco:b3707 http://www.genome.jp/dbget-bin/www_bget?eco:b3707 PDB 4UY8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4UY8 PDBsum 4UY8 http://www.ebi.ac.uk/pdbsum/4UY8 PSORT swissprot:LPTN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LPTN_ECOLI PSORT-B swissprot:LPTN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LPTN_ECOLI PSORT2 swissprot:LPTN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LPTN_ECOLI Pfam PF08053 http://pfam.xfam.org/family/PF08053 Phobius swissprot:LPTN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LPTN_ECOLI PubMed 12228716 http://www.ncbi.nlm.nih.gov/pubmed/12228716 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 25310980 http://www.ncbi.nlm.nih.gov/pubmed/25310980 PubMed 3902796 http://www.ncbi.nlm.nih.gov/pubmed/3902796 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418163 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418163 RefSeq WP_001364348 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001364348 SMR P0AD89 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AD89 STRING 511145.b3707 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3707&targetmode=cogs TIGRFAMs TIGR02616 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02616 UniProtKB LPTN_ECOLI http://www.uniprot.org/uniprot/LPTN_ECOLI UniProtKB-AC P0AD89 http://www.uniprot.org/uniprot/P0AD89 charge swissprot:LPTN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LPTN_ECOLI epestfind swissprot:LPTN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LPTN_ECOLI garnier swissprot:LPTN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LPTN_ECOLI helixturnhelix swissprot:LPTN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LPTN_ECOLI hmoment swissprot:LPTN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LPTN_ECOLI iep swissprot:LPTN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LPTN_ECOLI inforesidue swissprot:LPTN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LPTN_ECOLI octanol swissprot:LPTN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LPTN_ECOLI pepcoil swissprot:LPTN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LPTN_ECOLI pepdigest swissprot:LPTN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LPTN_ECOLI pepinfo swissprot:LPTN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LPTN_ECOLI pepnet swissprot:LPTN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LPTN_ECOLI pepstats swissprot:LPTN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LPTN_ECOLI pepwheel swissprot:LPTN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LPTN_ECOLI pepwindow swissprot:LPTN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LPTN_ECOLI sigcleave swissprot:LPTN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LPTN_ECOLI ## Database ID URL or Descriptions # AltName TUSD_ECOLI tRNA 2-thiouridine synthesizing protein D # BioGrid 4262469 33 # EcoGene EG12898 yheN # FUNCTION TUSD_ECOLI Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE. {ECO 0000269|PubMed 16387657}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0016783 sulfurtransferase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0097163 sulfur carrier activity; IDA:EcoCyc. # GO_process GO:0008033 tRNA processing; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006399 tRNA metabolic process # Gene3D 3.40.1260.10 -; 1. # HAMAP MF_00390 Thiourid_synth_D # InterPro IPR003787 Sulphur_relay_DrsE/F-like # InterPro IPR017463 Sulphur_relay_TusD/DsrE # InterPro IPR027396 DsrEFH-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # KEGG_Pathway ko04122 Sulfur relay system # Organism TUSD_ECOLI Escherichia coli (strain K12) # PATRIC 32122122 VBIEscCol129921_3438 # PDB 2D1P X-ray; 2.15 A; A/D/G=1-128 # PIR D65128 D65128 # Pfam PF02635 DrsE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TUSD_ECOLI Sulfurtransferase TusD # RefSeq NP_417804 NC_000913.3 # RefSeq WP_001209680 NZ_LN832404.1 # SIMILARITY Belongs to the DsrE/TusD family. {ECO 0000305}. # SUBCELLULAR LOCATION TUSD_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT TUSD_ECOLI Heterohexamer, formed by a dimer of trimers. The hexameric TusBCD complex contains 2 copies each of TusB, TusC and TusD. The TusBCD complex interacts with TusE. {ECO 0000269|PubMed 16387657, ECO 0000269|PubMed 16472754}. # SUPFAM SSF75169 SSF75169 # TIGRFAMs TIGR03012 sulf_tusD_dsrE # eggNOG COG1553 LUCA # eggNOG ENOG4108ZAT Bacteria BLAST swissprot:TUSD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TUSD_ECOLI BioCyc ECOL316407:JW3307-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3307-MONOMER BioCyc EcoCyc:G7714-MONOMER http://biocyc.org/getid?id=EcoCyc:G7714-MONOMER BioCyc MetaCyc:G7714-MONOMER http://biocyc.org/getid?id=MetaCyc:G7714-MONOMER COG COG1553 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1553 DIP DIP-12310N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12310N DOI 10.1016/j.molcel.2005.11.001 http://dx.doi.org/10.1016/j.molcel.2005.11.001 DOI 10.1016/j.str.2005.11.009 http://dx.doi.org/10.1016/j.str.2005.11.009 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.8.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.8.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 2.8.1.- http://enzyme.expasy.org/EC/2.8.1.- EchoBASE EB2735 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2735 EcoGene EG12898 http://www.ecogene.org/geneInfo.php?eg_id=EG12898 EnsemblBacteria AAC76370 http://www.ensemblgenomes.org/id/AAC76370 EnsemblBacteria AAC76370 http://www.ensemblgenomes.org/id/AAC76370 EnsemblBacteria BAE77946 http://www.ensemblgenomes.org/id/BAE77946 EnsemblBacteria BAE77946 http://www.ensemblgenomes.org/id/BAE77946 EnsemblBacteria BAE77946 http://www.ensemblgenomes.org/id/BAE77946 EnsemblBacteria b3345 http://www.ensemblgenomes.org/id/b3345 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0016783 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016783 GO_function GO:0097163 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097163 GO_process GO:0008033 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008033 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 Gene3D 3.40.1260.10 http://www.cathdb.info/version/latest/superfamily/3.40.1260.10 GeneID 947852 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947852 HAMAP MF_00390 http://hamap.expasy.org/unirule/MF_00390 HOGENOM HOG000229180 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000229180&db=HOGENOM6 InParanoid P45532 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45532 IntAct P45532 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45532* IntEnz 2.8.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.8.1 InterPro IPR003787 http://www.ebi.ac.uk/interpro/entry/IPR003787 InterPro IPR017463 http://www.ebi.ac.uk/interpro/entry/IPR017463 InterPro IPR027396 http://www.ebi.ac.uk/interpro/entry/IPR027396 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW3307 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3307 KEGG_Gene eco:b3345 http://www.genome.jp/dbget-bin/www_bget?eco:b3345 KEGG_Orthology KO:K07235 http://www.genome.jp/dbget-bin/www_bget?KO:K07235 KEGG_Pathway ko04122 http://www.genome.jp/kegg-bin/show_pathway?ko04122 OMA VFFYHDG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VFFYHDG PDB 2D1P http://www.ebi.ac.uk/pdbe-srv/view/entry/2D1P PDBsum 2D1P http://www.ebi.ac.uk/pdbsum/2D1P PSORT swissprot:TUSD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TUSD_ECOLI PSORT-B swissprot:TUSD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TUSD_ECOLI PSORT2 swissprot:TUSD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TUSD_ECOLI Pfam PF02635 http://pfam.xfam.org/family/PF02635 Phobius swissprot:TUSD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TUSD_ECOLI ProteinModelPortal P45532 http://www.proteinmodelportal.org/query/uniprot/P45532 PubMed 16387657 http://www.ncbi.nlm.nih.gov/pubmed/16387657 PubMed 16472754 http://www.ncbi.nlm.nih.gov/pubmed/16472754 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417804 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417804 RefSeq WP_001209680 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001209680 SMR P45532 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45532 STRING 511145.b3345 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3345&targetmode=cogs STRING COG1553 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1553&targetmode=cogs SUPFAM SSF75169 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF75169 TIGRFAMs TIGR03012 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03012 UniProtKB TUSD_ECOLI http://www.uniprot.org/uniprot/TUSD_ECOLI UniProtKB-AC P45532 http://www.uniprot.org/uniprot/P45532 charge swissprot:TUSD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TUSD_ECOLI eggNOG COG1553 http://eggnogapi.embl.de/nog_data/html/tree/COG1553 eggNOG ENOG4108ZAT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZAT epestfind swissprot:TUSD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TUSD_ECOLI garnier swissprot:TUSD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TUSD_ECOLI helixturnhelix swissprot:TUSD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TUSD_ECOLI hmoment swissprot:TUSD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TUSD_ECOLI iep swissprot:TUSD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TUSD_ECOLI inforesidue swissprot:TUSD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TUSD_ECOLI octanol swissprot:TUSD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TUSD_ECOLI pepcoil swissprot:TUSD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TUSD_ECOLI pepdigest swissprot:TUSD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TUSD_ECOLI pepinfo swissprot:TUSD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TUSD_ECOLI pepnet swissprot:TUSD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TUSD_ECOLI pepstats swissprot:TUSD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TUSD_ECOLI pepwheel swissprot:TUSD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TUSD_ECOLI pepwindow swissprot:TUSD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TUSD_ECOLI sigcleave swissprot:TUSD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TUSD_ECOLI ## Database ID URL or Descriptions # BioGrid 4260024 897 # CDD cd00207 fer2 # EcoGene EG13716 ycbX # GO_function GO:0003824 catalytic activity; IEA:InterPro. # GO_function GO:0009055 electron carrier activity; IEA:InterPro. # GO_function GO:0030151 molybdenum ion binding; IEA:InterPro. # GO_function GO:0030170 pyridoxal phosphate binding; IEA:InterPro. # GO_function GO:0051537 2 iron, 2 sulfur cluster binding; IEA:InterPro. # GO_process GO:0009407 toxin catabolic process; IMP:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0019748 secondary metabolic process # Gene3D 3.10.20.30 -; 1. # INTERACTION YCBX_ECOLI P38038 cysJ; NbExp=4; IntAct=EBI-544422, EBI-544440; # IntAct P75863 3 # InterPro IPR001041 2Fe-2S_ferredoxin-type # InterPro IPR005302 MoCF_Sase_C # InterPro IPR005303 MOSC_N # InterPro IPR006058 2Fe2S_fd_BS # InterPro IPR011037 Pyrv_Knase-like_insert_dom # InterPro IPR012675 Beta-grasp_dom # Organism YCBX_ECOLI Escherichia coli (strain K12) # PATRIC 32117113 VBIEscCol129921_0981 # PIR B64835 B64835 # PROSITE PS00197 2FE2S_FER_1 # PROSITE PS51085 2FE2S_FER_2 # PROSITE PS51340 MOSC # Pfam PF00111 Fer2 # Pfam PF03473 MOSC # Pfam PF03476 MOSC_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCBX_ECOLI Uncharacterized protein YcbX # RefSeq NP_415467 NC_000913.3 # RefSeq WP_000212426 NZ_LN832404.1 # SIMILARITY Contains 1 2Fe-2S ferredoxin-type domain. {ECO:0000255|PROSITE-ProRule PRU00465}. # SIMILARITY Contains 1 MOSC domain. {ECO:0000255|PROSITE- ProRule PRU00670}. # SUPFAM SSF50800 SSF50800; 2 # SUPFAM SSF54292 SSF54292 # eggNOG COG0633 LUCA # eggNOG COG3217 LUCA # eggNOG ENOG4105QVC Bacteria BLAST swissprot:YCBX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCBX_ECOLI BioCyc ECOL316407:JW5126-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5126-MONOMER BioCyc EcoCyc:G6487-MONOMER http://biocyc.org/getid?id=EcoCyc:G6487-MONOMER COG COG3217 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3217 DIP DIP-28068N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-28068N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3480 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3480 EcoGene EG13716 http://www.ecogene.org/geneInfo.php?eg_id=EG13716 EnsemblBacteria AAC74033 http://www.ensemblgenomes.org/id/AAC74033 EnsemblBacteria AAC74033 http://www.ensemblgenomes.org/id/AAC74033 EnsemblBacteria BAA35702 http://www.ensemblgenomes.org/id/BAA35702 EnsemblBacteria BAA35702 http://www.ensemblgenomes.org/id/BAA35702 EnsemblBacteria BAA35702 http://www.ensemblgenomes.org/id/BAA35702 EnsemblBacteria b0947 http://www.ensemblgenomes.org/id/b0947 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003824 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003824 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0030151 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030151 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_function GO:0051537 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051537 GO_process GO:0009407 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009407 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0019748 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019748 Gene3D 3.10.20.30 http://www.cathdb.info/version/latest/superfamily/3.10.20.30 GeneID 945563 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945563 HOGENOM HOG000180195 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000180195&db=HOGENOM6 InParanoid P75863 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75863 IntAct P75863 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75863* InterPro IPR001041 http://www.ebi.ac.uk/interpro/entry/IPR001041 InterPro IPR005302 http://www.ebi.ac.uk/interpro/entry/IPR005302 InterPro IPR005303 http://www.ebi.ac.uk/interpro/entry/IPR005303 InterPro IPR006058 http://www.ebi.ac.uk/interpro/entry/IPR006058 InterPro IPR011037 http://www.ebi.ac.uk/interpro/entry/IPR011037 InterPro IPR012675 http://www.ebi.ac.uk/interpro/entry/IPR012675 KEGG_Gene ecj:JW5126 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5126 KEGG_Gene eco:b0947 http://www.genome.jp/dbget-bin/www_bget?eco:b0947 KEGG_Orthology KO:K07140 http://www.genome.jp/dbget-bin/www_bget?KO:K07140 OMA GYPFLLI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GYPFLLI PROSITE PS00197 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00197 PROSITE PS51085 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51085 PROSITE PS51340 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51340 PSORT swissprot:YCBX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCBX_ECOLI PSORT-B swissprot:YCBX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCBX_ECOLI PSORT2 swissprot:YCBX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCBX_ECOLI Pfam PF00111 http://pfam.xfam.org/family/PF00111 Pfam PF03473 http://pfam.xfam.org/family/PF03473 Pfam PF03476 http://pfam.xfam.org/family/PF03476 Phobius swissprot:YCBX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCBX_ECOLI PhylomeDB P75863 http://phylomedb.org/?seqid=P75863 ProteinModelPortal P75863 http://www.proteinmodelportal.org/query/uniprot/P75863 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415467 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415467 RefSeq WP_000212426 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000212426 SMR P75863 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75863 STRING 511145.b0947 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0947&targetmode=cogs STRING COG3217 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3217&targetmode=cogs SUPFAM SSF50800 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50800 SUPFAM SSF54292 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54292 UniProtKB YCBX_ECOLI http://www.uniprot.org/uniprot/YCBX_ECOLI UniProtKB-AC P75863 http://www.uniprot.org/uniprot/P75863 charge swissprot:YCBX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCBX_ECOLI eggNOG COG0633 http://eggnogapi.embl.de/nog_data/html/tree/COG0633 eggNOG COG3217 http://eggnogapi.embl.de/nog_data/html/tree/COG3217 eggNOG ENOG4105QVC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105QVC epestfind swissprot:YCBX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCBX_ECOLI garnier swissprot:YCBX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCBX_ECOLI helixturnhelix swissprot:YCBX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCBX_ECOLI hmoment swissprot:YCBX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCBX_ECOLI iep swissprot:YCBX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCBX_ECOLI inforesidue swissprot:YCBX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCBX_ECOLI octanol swissprot:YCBX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCBX_ECOLI pepcoil swissprot:YCBX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCBX_ECOLI pepdigest swissprot:YCBX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCBX_ECOLI pepinfo swissprot:YCBX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCBX_ECOLI pepnet swissprot:YCBX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCBX_ECOLI pepstats swissprot:YCBX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCBX_ECOLI pepwheel swissprot:YCBX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCBX_ECOLI pepwindow swissprot:YCBX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCBX_ECOLI sigcleave swissprot:YCBX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCBX_ECOLI ## Database ID URL or Descriptions # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG13281 yedN # Gene3D 3.80.10.10 -; 1. # IntAct P76321 5 # InterPro IPR032675 L_dom-like # Organism YEDN_ECOLI Escherichia coli (strain K12) # Proteomes UP000000625 Chromosome # RecName YEDN_ECOLI Putative uncharacterized protein YedN # SEQUENCE CAUTION Sequence=L13279; Type=Erroneous termination; Positions=107; Note=Translated as Xaa.; Evidence={ECO:0000305}; Sequence=U00096; Type=Erroneous termination; Positions=107; Note=Translated as Xaa.; Evidence={ECO 0000305}; # SIMILARITY To S.flexneri IpaH 7.8 and Y.pestis YopM. {ECO 0000305}. # SUPFAM SSF52058 SSF52058 BLAST swissprot:YEDN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEDN_ECOLI BioCyc EcoCyc:G7041-MONOMER http://biocyc.org/getid?id=EcoCyc:G7041-MONOMER BioCyc EcoCyc:G7042-MONOMER http://biocyc.org/getid?id=EcoCyc:G7042-MONOMER DIP DIP-11846N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11846N DOI 10.1099/00221287-139-7-1401 http://dx.doi.org/10.1099/00221287-139-7-1401 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL L13279 http://www.ebi.ac.uk/ena/data/view/L13279 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3066 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3066 EcoGene EG13281 http://www.ecogene.org/geneInfo.php?eg_id=EG13281 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.80.10.10 http://www.cathdb.info/version/latest/superfamily/3.80.10.10 HOGENOM HOG000051767 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000051767&db=HOGENOM6 IntAct P76321 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76321* InterPro IPR032675 http://www.ebi.ac.uk/interpro/entry/IPR032675 PSORT swissprot:YEDN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEDN_ECOLI PSORT-B swissprot:YEDN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEDN_ECOLI PSORT2 swissprot:YEDN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEDN_ECOLI Phobius swissprot:YEDN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEDN_ECOLI ProteinModelPortal P76321 http://www.proteinmodelportal.org/query/uniprot/P76321 PubMed 8371104 http://www.ncbi.nlm.nih.gov/pubmed/8371104 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SUPFAM SSF52058 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52058 UniProtKB YEDN_ECOLI http://www.uniprot.org/uniprot/YEDN_ECOLI UniProtKB-AC P76321 http://www.uniprot.org/uniprot/P76321 charge swissprot:YEDN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEDN_ECOLI epestfind swissprot:YEDN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEDN_ECOLI garnier swissprot:YEDN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEDN_ECOLI helixturnhelix swissprot:YEDN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEDN_ECOLI hmoment swissprot:YEDN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEDN_ECOLI iep swissprot:YEDN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEDN_ECOLI inforesidue swissprot:YEDN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEDN_ECOLI octanol swissprot:YEDN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEDN_ECOLI pepcoil swissprot:YEDN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEDN_ECOLI pepdigest swissprot:YEDN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEDN_ECOLI pepinfo swissprot:YEDN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEDN_ECOLI pepnet swissprot:YEDN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEDN_ECOLI pepstats swissprot:YEDN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEDN_ECOLI pepwheel swissprot:YEDN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEDN_ECOLI pepwindow swissprot:YEDN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEDN_ECOLI sigcleave swissprot:YEDN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEDN_ECOLI ## Database ID URL or Descriptions # BioGrid 4261867 6 # EcoGene EG12004 yehR # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GOslim_component GO:0005886 plasma membrane # Gene3D 3.30.1830.10 -; 1. # IntAct P33354 6 # InterPro IPR009736 DUF1307 # Organism YEHR_ECOLI Escherichia coli (strain K12) # PATRIC 32119583 VBIEscCol129921_2202 # PDB 2JOE NMR; -; A=24-153 # PIRSF PIRSF006187 DUF1307 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF06998 DUF1307 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEHR_ECOLI Uncharacterized lipoprotein YehR # RefSeq NP_416627 NC_000913.3 # RefSeq WP_001295429 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA60486.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY To L.monocytogenes lmo0207. {ECO 0000305}. # SUBCELLULAR LOCATION YEHR_ECOLI Cell membrane {ECO 0000255|PROSITE- ProRule PRU00303}; Lipid-anchor {ECO 0000255|PROSITE- ProRule PRU00303}. # SUPFAM SSF160704 SSF160704 # eggNOG COG4808 LUCA # eggNOG ENOG4108YCW Bacteria BLAST swissprot:YEHR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEHR_ECOLI BioCyc ECOL316407:JW5351-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5351-MONOMER BioCyc EcoCyc:EG12004-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12004-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1942 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1942 EcoGene EG12004 http://www.ecogene.org/geneInfo.php?eg_id=EG12004 EnsemblBacteria AAC75184 http://www.ensemblgenomes.org/id/AAC75184 EnsemblBacteria AAC75184 http://www.ensemblgenomes.org/id/AAC75184 EnsemblBacteria BAE76599 http://www.ensemblgenomes.org/id/BAE76599 EnsemblBacteria BAE76599 http://www.ensemblgenomes.org/id/BAE76599 EnsemblBacteria BAE76599 http://www.ensemblgenomes.org/id/BAE76599 EnsemblBacteria b2123 http://www.ensemblgenomes.org/id/b2123 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 Gene3D 3.30.1830.10 http://www.cathdb.info/version/latest/superfamily/3.30.1830.10 GeneID 949023 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949023 HOGENOM HOG000122211 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122211&db=HOGENOM6 IntAct P33354 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33354* InterPro IPR009736 http://www.ebi.ac.uk/interpro/entry/IPR009736 KEGG_Gene ecj:JW5351 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5351 KEGG_Gene eco:b2123 http://www.genome.jp/dbget-bin/www_bget?eco:b2123 OMA THEIDYQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=THEIDYQ PDB 2JOE http://www.ebi.ac.uk/pdbe-srv/view/entry/2JOE PDBsum 2JOE http://www.ebi.ac.uk/pdbsum/2JOE PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YEHR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEHR_ECOLI PSORT-B swissprot:YEHR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEHR_ECOLI PSORT2 swissprot:YEHR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEHR_ECOLI Pfam PF06998 http://pfam.xfam.org/family/PF06998 Phobius swissprot:YEHR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEHR_ECOLI ProteinModelPortal P33354 http://www.proteinmodelportal.org/query/uniprot/P33354 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416627 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416627 RefSeq WP_001295429 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295429 SMR P33354 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33354 STRING 511145.b2123 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2123&targetmode=cogs SUPFAM SSF160704 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF160704 UniProtKB YEHR_ECOLI http://www.uniprot.org/uniprot/YEHR_ECOLI UniProtKB-AC P33354 http://www.uniprot.org/uniprot/P33354 charge swissprot:YEHR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEHR_ECOLI eggNOG COG4808 http://eggnogapi.embl.de/nog_data/html/tree/COG4808 eggNOG ENOG4108YCW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108YCW epestfind swissprot:YEHR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEHR_ECOLI garnier swissprot:YEHR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEHR_ECOLI helixturnhelix swissprot:YEHR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEHR_ECOLI hmoment swissprot:YEHR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEHR_ECOLI iep swissprot:YEHR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEHR_ECOLI inforesidue swissprot:YEHR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEHR_ECOLI octanol swissprot:YEHR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEHR_ECOLI pepcoil swissprot:YEHR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEHR_ECOLI pepdigest swissprot:YEHR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEHR_ECOLI pepinfo swissprot:YEHR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEHR_ECOLI pepnet swissprot:YEHR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEHR_ECOLI pepstats swissprot:YEHR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEHR_ECOLI pepwheel swissprot:YEHR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEHR_ECOLI pepwindow swissprot:YEHR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEHR_ECOLI sigcleave swissprot:YEHR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEHR_ECOLI ## Database ID URL or Descriptions # BioGrid 4259847 148 # DISRUPTION PHENOTYPE Mutant exhibits increased sensitivity to H(2)O(2) stress. {ECO:0000269|PubMed 24038693}. # EcoGene EG13259 fetA # FUNCTION FETA_ECOLI Part of the ABC transporter complex FetAB, which is probably involved in iron export and enhances resistance to H(2)O(2)-mediated oxidative stress. Probably responsible for energy coupling to the transport system. {ECO 0000269|PubMed 24038693}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016887 ATPase activity; IEA:InterPro. # GO_process GO:0006811 ion transport; IEA:UniProtKB-KW. # GO_process GO:0006879 cellular iron ion homeostasis; IMP:EcoCyc. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # GOslim_process GO:0042592 homeostatic process # Gene3D 3.40.50.300 -; 1. # INTERACTION FETA_ECOLI P0A6F5 groL; NbExp=2; IntAct=EBI-560090, EBI-543750; # IntAct P77279 6 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00211 Putative ABC transport system # KEGG_Brite ko02000 Transporters # Organism FETA_ECOLI Escherichia coli (strain K12) # PATRIC 32116139 VBIEscCol129921_0511 # PIR A64780 A64780 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # Pfam PF00005 ABC_tran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FETA_ECOLI Probable iron export ATP-binding protein FetA # RefSeq NP_415023 NC_000913.3 # RefSeq WP_001157540 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA # SUBCELLULAR LOCATION FETA_ECOLI Cell inner membrane {ECO 0000250}; Peripheral membrane protein {ECO 0000250}. # SUBUNIT The complex is composed of two ATP-binding proteins (FetA) and two transmembrane proteins (FetB). {ECO 0000250}. # SUPFAM SSF52540 SSF52540 # TCDB 3.A.1.139 the atp-binding cassette (abc) superfamily # eggNOG COG4619 LUCA # eggNOG ENOG41083J0 Bacteria BLAST swissprot:FETA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FETA_ECOLI BioCyc ECOL316407:JW0479-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0479-MONOMER BioCyc EcoCyc:YBBL-MONOMER http://biocyc.org/getid?id=EcoCyc:YBBL-MONOMER COG COG4619 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4619 DIP DIP-11320N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11320N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AEM.02322-13 http://dx.doi.org/10.1128/AEM.02322-13 EC_number EC:3.6.3.- http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 ENZYME 3.6.3.- http://enzyme.expasy.org/EC/3.6.3.- EchoBASE EB3047 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3047 EcoGene EG13259 http://www.ecogene.org/geneInfo.php?eg_id=EG13259 EnsemblBacteria AAC73592 http://www.ensemblgenomes.org/id/AAC73592 EnsemblBacteria AAC73592 http://www.ensemblgenomes.org/id/AAC73592 EnsemblBacteria BAE76269 http://www.ensemblgenomes.org/id/BAE76269 EnsemblBacteria BAE76269 http://www.ensemblgenomes.org/id/BAE76269 EnsemblBacteria BAE76269 http://www.ensemblgenomes.org/id/BAE76269 EnsemblBacteria b0490 http://www.ensemblgenomes.org/id/b0490 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_process GO:0006811 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811 GO_process GO:0006879 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006879 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 946990 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946990 InParanoid P77279 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77279 IntAct P77279 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77279* IntEnz 3.6.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3 InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0479 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0479 KEGG_Gene eco:b0490 http://www.genome.jp/dbget-bin/www_bget?eco:b0490 KEGG_Orthology KO:K02068 http://www.genome.jp/dbget-bin/www_bget?KO:K02068 MINT MINT-1269507 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1269507 OMA QETRYER http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QETRYER PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:FETA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FETA_ECOLI PSORT-B swissprot:FETA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FETA_ECOLI PSORT2 swissprot:FETA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FETA_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Phobius swissprot:FETA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FETA_ECOLI PhylomeDB P77279 http://phylomedb.org/?seqid=P77279 ProteinModelPortal P77279 http://www.proteinmodelportal.org/query/uniprot/P77279 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 24038693 http://www.ncbi.nlm.nih.gov/pubmed/24038693 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415023 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415023 RefSeq WP_001157540 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001157540 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P77279 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77279 STRING 511145.b0490 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0490&targetmode=cogs STRING COG4619 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4619&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.139 http://www.tcdb.org/search/result.php?tc=3.A.1.139 UniProtKB FETA_ECOLI http://www.uniprot.org/uniprot/FETA_ECOLI UniProtKB-AC P77279 http://www.uniprot.org/uniprot/P77279 charge swissprot:FETA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FETA_ECOLI eggNOG COG4619 http://eggnogapi.embl.de/nog_data/html/tree/COG4619 eggNOG ENOG41083J0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41083J0 epestfind swissprot:FETA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FETA_ECOLI garnier swissprot:FETA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FETA_ECOLI helixturnhelix swissprot:FETA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FETA_ECOLI hmoment swissprot:FETA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FETA_ECOLI iep swissprot:FETA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FETA_ECOLI inforesidue swissprot:FETA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FETA_ECOLI octanol swissprot:FETA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FETA_ECOLI pepcoil swissprot:FETA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FETA_ECOLI pepdigest swissprot:FETA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FETA_ECOLI pepinfo swissprot:FETA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FETA_ECOLI pepnet swissprot:FETA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FETA_ECOLI pepstats swissprot:FETA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FETA_ECOLI pepwheel swissprot:FETA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FETA_ECOLI pepwindow swissprot:FETA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FETA_ECOLI sigcleave swissprot:FETA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FETA_ECOLI ## Database ID URL or Descriptions # AltName EPMB_ECOLI EF-P post-translational modification enzyme B # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=5 mM for L-lysine (at pH 8 and 25 degrees Celsius) {ECO 0000269|PubMed:17042480}; Note=kcat is 4.8 min(-1) (at pH 8 and 25 degrees Celsius).; # CATALYTIC ACTIVITY L-lysine = (3R)-3,6-diaminohexanoate. {ECO:0000269|PubMed 17042480}. # COFACTOR EPMB_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000269|PubMed 17042480}; Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. {ECO 0000269|PubMed 17042480}; # COFACTOR EPMB_ECOLI Name=pyridoxal 5'-phosphate; Xref=ChEBI CHEBI 597326; Evidence={ECO 0000269|PubMed 17042480}; # DISRUPTION PHENOTYPE Cells lack CadA activity (lysine decarboxylase). {ECO:0000269|PubMed 23239623}. # EcoGene EG12473 epmB # FUNCTION EPMB_ECOLI With EpmA is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P) on 'Lys-34'. EpmB appears to act before EpmA. Displays lysine 2,3-aminomutase activity, producing (R)-beta-lysine from (S)-alpha-lysine (L-lysine). Cannot use (S)-ornithine or (R)- alpha-lysine as a substrate. {ECO 0000269|PubMed 17042480, ECO 0000269|PubMed 20729861, ECO 0000269|PubMed 22128152}. # GO_function GO:0016869 intramolecular transferase activity, transferring amino groups; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IDA:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # Gene3D 3.20.20.70 -; 1. # IntAct P39280 16 # InterPro IPR003739 Lys_aminomutase/Glu_NH3_mut # InterPro IPR007197 rSAM # InterPro IPR013785 Aldolase_TIM # InterPro IPR022462 EpmB # Organism EPMB_ECOLI Escherichia coli (strain K12) # PATRIC 32123861 VBIEscCol129921_4278 # PIR S56374 S56374 # PIRSF PIRSF004911 DUF160 # Pfam PF04055 Radical_SAM # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EPMB_ECOLI L-lysine 2,3-aminomutase # RefSeq NP_418570 NC_000913.3 # RefSeq WP_000940549 NZ_LN832404.1 # SIMILARITY Belongs to the radical SAM superfamily. KamA family. {ECO 0000305}. # TIGRFAMs TIGR00238 TIGR00238 # TIGRFAMs TIGR03821 EFP_modif_epmB # eggNOG COG1509 LUCA # eggNOG ENOG4105CK3 Bacteria BLAST swissprot:EPMB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EPMB_ECOLI BioCyc ECOL316407:JW4106-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4106-MONOMER BioCyc EcoCyc:G7836-MONOMER http://biocyc.org/getid?id=EcoCyc:G7836-MONOMER BioCyc MetaCyc:G7836-MONOMER http://biocyc.org/getid?id=MetaCyc:G7836-MONOMER DOI 10.1021/bi061328t http://dx.doi.org/10.1021/bi061328t DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nchembio.1001 http://dx.doi.org/10.1038/nchembio.1001 DOI 10.1038/nsmb.1889 http://dx.doi.org/10.1038/nsmb.1889 DOI 10.1074/jbc.M111.309633 http://dx.doi.org/10.1074/jbc.M111.309633 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.1228985 http://dx.doi.org/10.1126/science.1228985 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1186/1745-6150-5-3 http://dx.doi.org/10.1186/1745-6150-5-3 EC_number EC:5.4.3.- http://www.genome.jp/dbget-bin/www_bget?EC:5.4.3.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 5.4.3.- http://enzyme.expasy.org/EC/5.4.3.- EchoBASE EB2366 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2366 EcoGene EG12473 http://www.ecogene.org/geneInfo.php?eg_id=EG12473 EnsemblBacteria AAC77106 http://www.ensemblgenomes.org/id/AAC77106 EnsemblBacteria AAC77106 http://www.ensemblgenomes.org/id/AAC77106 EnsemblBacteria BAE78148 http://www.ensemblgenomes.org/id/BAE78148 EnsemblBacteria BAE78148 http://www.ensemblgenomes.org/id/BAE78148 EnsemblBacteria BAE78148 http://www.ensemblgenomes.org/id/BAE78148 EnsemblBacteria b4146 http://www.ensemblgenomes.org/id/b4146 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016869 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016869 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 948662 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948662 HOGENOM HOG000223517 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000223517&db=HOGENOM6 InParanoid P39280 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39280 IntAct P39280 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39280* IntEnz 5.4.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.4.3 InterPro IPR003739 http://www.ebi.ac.uk/interpro/entry/IPR003739 InterPro IPR007197 http://www.ebi.ac.uk/interpro/entry/IPR007197 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR022462 http://www.ebi.ac.uk/interpro/entry/IPR022462 KEGG_Gene ecj:JW4106 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4106 KEGG_Gene eco:b4146 http://www.genome.jp/dbget-bin/www_bget?eco:b4146 OMA HFPYADN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HFPYADN PSORT swissprot:EPMB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EPMB_ECOLI PSORT-B swissprot:EPMB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EPMB_ECOLI PSORT2 swissprot:EPMB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EPMB_ECOLI Pfam PF04055 http://pfam.xfam.org/family/PF04055 Phobius swissprot:EPMB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EPMB_ECOLI PhylomeDB P39280 http://phylomedb.org/?seqid=P39280 ProteinModelPortal P39280 http://www.proteinmodelportal.org/query/uniprot/P39280 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17042480 http://www.ncbi.nlm.nih.gov/pubmed/17042480 PubMed 20070887 http://www.ncbi.nlm.nih.gov/pubmed/20070887 PubMed 20729861 http://www.ncbi.nlm.nih.gov/pubmed/20729861 PubMed 22128152 http://www.ncbi.nlm.nih.gov/pubmed/22128152 PubMed 22706199 http://www.ncbi.nlm.nih.gov/pubmed/22706199 PubMed 23239623 http://www.ncbi.nlm.nih.gov/pubmed/23239623 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418570 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418570 RefSeq WP_000940549 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000940549 SMR P39280 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39280 STRING 511145.b4146 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4146&targetmode=cogs TIGRFAMs TIGR00238 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00238 TIGRFAMs TIGR03821 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03821 UniProtKB EPMB_ECOLI http://www.uniprot.org/uniprot/EPMB_ECOLI UniProtKB-AC P39280 http://www.uniprot.org/uniprot/P39280 charge swissprot:EPMB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EPMB_ECOLI eggNOG COG1509 http://eggnogapi.embl.de/nog_data/html/tree/COG1509 eggNOG ENOG4105CK3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CK3 epestfind swissprot:EPMB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EPMB_ECOLI garnier swissprot:EPMB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EPMB_ECOLI helixturnhelix swissprot:EPMB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EPMB_ECOLI hmoment swissprot:EPMB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EPMB_ECOLI iep swissprot:EPMB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EPMB_ECOLI inforesidue swissprot:EPMB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EPMB_ECOLI octanol swissprot:EPMB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EPMB_ECOLI pepcoil swissprot:EPMB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EPMB_ECOLI pepdigest swissprot:EPMB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EPMB_ECOLI pepinfo swissprot:EPMB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EPMB_ECOLI pepnet swissprot:EPMB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EPMB_ECOLI pepstats swissprot:EPMB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EPMB_ECOLI pepwheel swissprot:EPMB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EPMB_ECOLI pepwindow swissprot:EPMB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EPMB_ECOLI sigcleave swissprot:EPMB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EPMB_ECOLI ## Database ID URL or Descriptions # ALTERNATIVE PRODUCTS PBPB_ECOLI Event=Alternative initiation; Named isoforms=2; Name=Alpha; Synonyms=Long; IsoId=P02919-1; Sequence=Displayed; Name=Gamma; Synonyms=Short; IsoId=P02919-2; Sequence=VSP_018737; # AltName PBPB_ECOLI DD-transpeptidase # AltName PBPB_ECOLI Murein polymerase # AltName PBPB_ECOLI Murein polymerase # AltName PBPB_ECOLI Peptidoglycan TGase # AltName PBPB_ECOLI Peptidoglycan glycosyltransferase # AltName PBPB_ECOLI Peptidoglycan glycosyltransferase # BRENDA 2.4.1.129 2026 # BioGrid 4260880 237 # CATALYTIC ACTIVITY (GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L- Lys-D-Ala-D-Ala))(n)-diphosphoundecaprenol + GlcNAc-(1->4)- Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)- diphosphoundecaprenol = (GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D- Glu-L-Lys-D-Ala-D-Ala))(n+1)-diphosphoundecaprenol + undecaprenyl diphosphate. {ECO:0000269|PubMed 19458048}. # CAZy GT51 Glycosyltransferase Family 51 # DOMAIN PBPB_ECOLI The UvrB domain 2 homolog region (UB2H domain) is important for interaction with MltA. {ECO 0000269|PubMed 19458048}. # DrugBank DB00274 Cefmetazole # DrugBank DB00303 Ertapenem # DrugBank DB00430 Cefpiramide # DrugBank DB00438 Ceftazidime # DrugBank DB01327 Cefazolin # DrugBank DB01328 Cefonicid # DrugBank DB01329 Cefoperazone # DrugBank DB01331 Cefoxitin # DrugBank DB01332 Ceftizoxime # DrugBank DB01414 Cefacetrile # DrugBank DB01415 Ceftibuten # DrugBank DB01598 Imipenem # DrugBank DB04570 Latamoxef # DrugBank DB06211 Doripenem # EcoGene EG10605 mrcB # FUNCTION PBPB_ECOLI Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits). # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0009274 peptidoglycan-based cell wall; IEA:InterPro. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_component GO:0071575 integral component of external side of plasma membrane; IDA:EcoCyc. # GO_function GO:0008144 drug binding; IDA:EcoCyc. # GO_function GO:0008658 penicillin binding; IDA:EcoCyc. # GO_function GO:0008955 peptidoglycan glycosyltransferase activity; IDA:EcoCyc. # GO_function GO:0009002 serine-type D-Ala-D-Ala carboxypeptidase activity; IDA:EcoCyc. # GO_process GO:0008360 regulation of cell shape; IGI:EcoCyc. # GO_process GO:0009252 peptidoglycan biosynthetic process; IGI:EcoCyc. # GO_process GO:0046677 response to antibiotic; IGI:EcoCyc. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005618 cell wall # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 3.40.710.10 -; 1. # INTERACTION PBPB_ECOLI P29131 ftsN; NbExp=6; IntAct=EBI-909769, EBI-1134233; P0AB38 lpoB; NbExp=4; IntAct=EBI-909769, EBI-3405489; # IntAct P02919 9 # InterPro IPR001264 Glyco_trans_51 # InterPro IPR001460 PCN-bd_Tpept # InterPro IPR011813 PBP_1b # InterPro IPR012338 Beta-lactam/transpept-like # InterPro IPR023346 Lysozyme-like_dom # InterPro IPR028166 UB2H # InterPro IPR032730 PBP1b_TM # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01003 Glycosyltransferases # KEGG_Pathway ko00550 Peptidoglycan biosynthesis # MISCELLANEOUS PBPB_ECOLI A third isozyme, Beta, lacking the first 25 N- terminal amino acids of the isoform Alpha and a fourth isozyme, Delta, have been found, but seem to result from the artifactual degradation of the isoform Alpha and isoform Gamma respectively. # Organism PBPB_ECOLI Escherichia coli (strain K12) # PATHWAY PBPB_ECOLI Cell wall biogenesis; peptidoglycan biosynthesis. # PATRIC 32115405 VBIEscCol129921_0154 # PDB 3FWL X-ray; 3.09 A; A=58-804 # PDB 3VMA X-ray; 2.16 A; A=58-804 # PDB 5FGZ X-ray; 2.85 A; A=58-804 # PIR E64738 ZPECPB # PIRSF PIRSF002799 PBP_1b # Pfam PF00905 Transpeptidase # Pfam PF00912 Transgly # Pfam PF14812 PBP1_TM # Pfam PF14814 UB2H # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PBPB_ECOLI Penicillin-binding protein 1B # RecName PBPB_ECOLI Penicillin-insensitive transglycosylase # RecName PBPB_ECOLI Penicillin-sensitive transpeptidase # RefSeq NP_414691 NC_000913.3 # RefSeq WP_000918162 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA26099.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY In the C-terminal section; belongs to the transpeptidase family. {ECO 0000305}. # SIMILARITY In the N-terminal section; belongs to the glycosyltransferase 51 family. {ECO 0000305}. # SUBCELLULAR LOCATION PBPB_ECOLI Cell inner membrane; Single-pass type II membrane protein. # SUBUNIT PBPB_ECOLI Forms a trimeric complex with MipA and MltA. Has also been shown to exist as monomer or homodimer; homodimer of Alpha and Gamma isozymes can be found. Interacts with UvrA, FtsL and FtsN. {ECO 0000269|PubMed 10037771, ECO 0000269|PubMed 19458048}. # SUPFAM SSF53955 SSF53955 # SUPFAM SSF56601 SSF56601; 2 # TIGRFAMs TIGR02071 PBP_1b # eggNOG COG0744 LUCA # eggNOG ENOG4105BZ4 Bacteria BLAST swissprot:PBPB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PBPB_ECOLI BioCyc ECOL316407:JW0145-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0145-MONOMER BioCyc EcoCyc:EG10605-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10605-MONOMER BioCyc MetaCyc:EG10605-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10605-MONOMER COG CAZy: http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=CAZy: COG COG0744 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0744 COG GT51 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=GT51 DIP DIP-10252N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10252N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj3160149 http://dx.doi.org/10.1042/bj3160149 DOI 10.1046/j.1365-2958.1999.01612.x http://dx.doi.org/10.1046/j.1365-2958.1999.01612.x DOI 10.1073/pnas.0904030106 http://dx.doi.org/10.1073/pnas.0904030106 DOI 10.1073/pnas.82.7.1999 http://dx.doi.org/10.1073/pnas.82.7.1999 DOI 10.1074/jbc.274.10.6726 http://dx.doi.org/10.1074/jbc.274.10.6726 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1111/j.1365-2958.1987.tb00533.x http://dx.doi.org/10.1111/j.1365-2958.1987.tb00533.x DOI 10.1111/j.1432-1033.1985.tb08768.x http://dx.doi.org/10.1111/j.1432-1033.1985.tb08768.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB00274 http://www.drugbank.ca/drugs/DB00274 DrugBank DB00303 http://www.drugbank.ca/drugs/DB00303 DrugBank DB00430 http://www.drugbank.ca/drugs/DB00430 DrugBank DB00438 http://www.drugbank.ca/drugs/DB00438 DrugBank DB01327 http://www.drugbank.ca/drugs/DB01327 DrugBank DB01328 http://www.drugbank.ca/drugs/DB01328 DrugBank DB01329 http://www.drugbank.ca/drugs/DB01329 DrugBank DB01331 http://www.drugbank.ca/drugs/DB01331 DrugBank DB01332 http://www.drugbank.ca/drugs/DB01332 DrugBank DB01414 http://www.drugbank.ca/drugs/DB01414 DrugBank DB01415 http://www.drugbank.ca/drugs/DB01415 DrugBank DB01598 http://www.drugbank.ca/drugs/DB01598 DrugBank DB04570 http://www.drugbank.ca/drugs/DB04570 DrugBank DB06211 http://www.drugbank.ca/drugs/DB06211 EC_number EC:2.4.1.129 http://www.genome.jp/dbget-bin/www_bget?EC:2.4.1.129 EC_number EC:3.4.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.4.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X02163 http://www.ebi.ac.uk/ena/data/view/X02163 EMBL X02163 http://www.ebi.ac.uk/ena/data/view/X02163 ENZYME 2.4.1.129 http://enzyme.expasy.org/EC/2.4.1.129 ENZYME 3.4.-.- http://enzyme.expasy.org/EC/3.4.-.- EchoBASE EB0600 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0600 EcoGene EG10605 http://www.ecogene.org/geneInfo.php?eg_id=EG10605 EnsemblBacteria AAC73260 http://www.ensemblgenomes.org/id/AAC73260 EnsemblBacteria AAC73260 http://www.ensemblgenomes.org/id/AAC73260 EnsemblBacteria BAB96725 http://www.ensemblgenomes.org/id/BAB96725 EnsemblBacteria BAB96725 http://www.ensemblgenomes.org/id/BAB96725 EnsemblBacteria BAB96725 http://www.ensemblgenomes.org/id/BAB96725 EnsemblBacteria b0149 http://www.ensemblgenomes.org/id/b0149 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0009274 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009274 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0071575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071575 GO_function GO:0008144 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008144 GO_function GO:0008658 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008658 GO_function GO:0008955 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008955 GO_function GO:0009002 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009002 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0009252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009252 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005618 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 3.40.710.10 http://www.cathdb.info/version/latest/superfamily/3.40.710.10 GeneID 944843 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944843 HOGENOM HOG000282711 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000282711&db=HOGENOM6 InParanoid P02919 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P02919 IntAct P02919 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P02919* IntEnz 2.4.1.129 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.1.129 IntEnz 3.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4 InterPro IPR001264 http://www.ebi.ac.uk/interpro/entry/IPR001264 InterPro IPR001460 http://www.ebi.ac.uk/interpro/entry/IPR001460 InterPro IPR011813 http://www.ebi.ac.uk/interpro/entry/IPR011813 InterPro IPR012338 http://www.ebi.ac.uk/interpro/entry/IPR012338 InterPro IPR023346 http://www.ebi.ac.uk/interpro/entry/IPR023346 InterPro IPR028166 http://www.ebi.ac.uk/interpro/entry/IPR028166 InterPro IPR032730 http://www.ebi.ac.uk/interpro/entry/IPR032730 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01003 http://www.genome.jp/dbget-bin/www_bget?ko01003 KEGG_Gene ecj:JW0145 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0145 KEGG_Gene eco:b0149 http://www.genome.jp/dbget-bin/www_bget?eco:b0149 KEGG_Orthology KO:K05365 http://www.genome.jp/dbget-bin/www_bget?KO:K05365 KEGG_Pathway ko00550 http://www.genome.jp/kegg-bin/show_pathway?ko00550 KEGG_Reaction rn:R04519 http://www.genome.jp/dbget-bin/www_bget?rn:R04519 OMA RALMANY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RALMANY PDB 3FWL http://www.ebi.ac.uk/pdbe-srv/view/entry/3FWL PDB 3VMA http://www.ebi.ac.uk/pdbe-srv/view/entry/3VMA PDB 5FGZ http://www.ebi.ac.uk/pdbe-srv/view/entry/5FGZ PDBsum 3FWL http://www.ebi.ac.uk/pdbsum/3FWL PDBsum 3VMA http://www.ebi.ac.uk/pdbsum/3VMA PDBsum 5FGZ http://www.ebi.ac.uk/pdbsum/5FGZ PSORT swissprot:PBPB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PBPB_ECOLI PSORT-B swissprot:PBPB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PBPB_ECOLI PSORT2 swissprot:PBPB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PBPB_ECOLI Pfam PF00905 http://pfam.xfam.org/family/PF00905 Pfam PF00912 http://pfam.xfam.org/family/PF00912 Pfam PF14812 http://pfam.xfam.org/family/PF14812 Pfam PF14814 http://pfam.xfam.org/family/PF14814 Phobius swissprot:PBPB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PBPB_ECOLI PhylomeDB P02919 http://phylomedb.org/?seqid=P02919 ProteinModelPortal P02919 http://www.proteinmodelportal.org/query/uniprot/P02919 PubMed 10037771 http://www.ncbi.nlm.nih.gov/pubmed/10037771 PubMed 10564478 http://www.ncbi.nlm.nih.gov/pubmed/10564478 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1885547 http://www.ncbi.nlm.nih.gov/pubmed/1885547 PubMed 19458048 http://www.ncbi.nlm.nih.gov/pubmed/19458048 PubMed 3330753 http://www.ncbi.nlm.nih.gov/pubmed/3330753 PubMed 3882429 http://www.ncbi.nlm.nih.gov/pubmed/3882429 PubMed 3920658 http://www.ncbi.nlm.nih.gov/pubmed/3920658 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 8645198 http://www.ncbi.nlm.nih.gov/pubmed/8645198 PubMed 9244263 http://www.ncbi.nlm.nih.gov/pubmed/9244263 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9841666 http://www.ncbi.nlm.nih.gov/pubmed/9841666 RefSeq NP_414691 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414691 RefSeq WP_000918162 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000918162 SMR P02919 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P02919 STRING 511145.b0149 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0149&targetmode=cogs STRING CAZy: http://string-db.org/newstring_cgi/show_network_section.pl?identifier=CAZy:&targetmode=cogs STRING COG0744 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0744&targetmode=cogs STRING GT51 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=GT51&targetmode=cogs SUPFAM SSF53955 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53955 SUPFAM SSF56601 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56601 TIGRFAMs TIGR02071 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02071 UniProtKB PBPB_ECOLI http://www.uniprot.org/uniprot/PBPB_ECOLI UniProtKB-AC P02919 http://www.uniprot.org/uniprot/P02919 charge swissprot:PBPB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PBPB_ECOLI eggNOG COG0744 http://eggnogapi.embl.de/nog_data/html/tree/COG0744 eggNOG ENOG4105BZ4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZ4 epestfind swissprot:PBPB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PBPB_ECOLI garnier swissprot:PBPB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PBPB_ECOLI helixturnhelix swissprot:PBPB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PBPB_ECOLI hmoment swissprot:PBPB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PBPB_ECOLI iep swissprot:PBPB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PBPB_ECOLI inforesidue swissprot:PBPB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PBPB_ECOLI octanol swissprot:PBPB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PBPB_ECOLI pepcoil swissprot:PBPB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PBPB_ECOLI pepdigest swissprot:PBPB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PBPB_ECOLI pepinfo swissprot:PBPB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PBPB_ECOLI pepnet swissprot:PBPB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PBPB_ECOLI pepstats swissprot:PBPB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PBPB_ECOLI pepwheel swissprot:PBPB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PBPB_ECOLI pepwindow swissprot:PBPB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PBPB_ECOLI sigcleave swissprot:PBPB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PBPB_ECOLI ## Database ID URL or Descriptions # AltName DGOA_ECOLI 2-oxo-3-deoxygalactonate 6-phosphate aldolase # AltName DGOA_ECOLI 6-phospho-2-dehydro-3-deoxygalactonate aldolase # AltName DGOA_ECOLI 6-phospho-2-keto-3-deoxygalactonate aldolase # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=0.2 mM for KDPGal {ECO 0000269|PubMed:17981470}; Note=Kcat is 4 sec(-1) for KDPGal.; # BioGrid 4260839 13 # CATALYTIC ACTIVITY 2-dehydro-3-deoxy-6-phospho-D-galactonate = pyruvate + D-glyceraldehyde 3-phosphate. {ECO:0000269|PubMed 17981470}. # CDD cd00452 KDPG_aldolase # EcoGene EG11716 dgoA # FUNCTION DGOA_ECOLI Involved in the degradation of galactose via the DeLey- Doudoroff pathway. Catalyzes the reversible, stereospecific retro- aldol cleavage of 2-keto-3-deoxy-6-phosphogalactonate (KDPGal) to pyruvate and D-glyceraldehyde-3-phosphate. In the synthetic direction, it catalyzes the addition of pyruvate to electrophilic aldehydes with re-facial selectivity. It can use a limited number of aldehyde substrates, including D-glyceraldehyde-3-phosphate (natural substrate), D-glyceraldehyde, glycolaldehyde, 2- pyridinecarboxaldehyde, D-ribose, D-erythrose and D-threose. It efficiently catalyzes aldol addition only using pyruvate as the nucleophilic component and accepts both stereochemical configurations at C2 of the electrophile. {ECO 0000269|PubMed 17981470, ECO 0000269|PubMed 324806}. # GO_function GO:0008674 2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity; IDA:EcoCyc. # GO_process GO:0034194 D-galactonate catabolic process; IMP:EcoCyc. # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.70 -; 1. # INDUCTION By galactonate and galactose. {ECO:0000269|PubMed 324806}. # InterPro IPR000887 Aldlse_KDPG_KHG # InterPro IPR013785 Aldolase_TIM # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00052 Galactose metabolism # MASS SPECTROMETRY Mass=21383; Method=MALDI; Range=1-205; Evidence={ECO:0000269|PubMed 17981470}; # Organism DGOA_ECOLI Escherichia coli (strain K12) # PATHWAY Carbohydrate acid metabolism; D-galactonate degradation; D-glyceraldehyde 3-phosphate and pyruvate from D-galactonate step 3/3. # PATRIC 32122881 VBIEscCol129921_3816 # PDB 2V81 X-ray; 2.40 A; A=1-205 # PDB 2V82 X-ray; 2.10 A; A=1-205 # PDB 4QCC X-ray; 7.08 A; A/B=1-203 # PIR E65171 E65171 # Pfam PF01081 Aldolase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DGOA_ECOLI 2-dehydro-3-deoxy-6-phosphogalactonate aldolase # RefSeq WP_001198722 NZ_LN832404.1 # RefSeq YP_026238 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA62044.1; Type=Frameshift; Positions=124, 160, 204; Note=The frameshift in position 204 caused the prediction of an ORF that fused dgoA and dgoD.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the KHG/KDPG aldolase family. {ECO 0000305}. # SUBUNIT Homotrimer. {ECO:0000269|PubMed 17981470}. # UniPathway UPA00081 UER00520 # eggNOG COG0800 LUCA # eggNOG ENOG4108RTU Bacteria BLAST swissprot:DGOA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DGOA_ECOLI BioCyc ECOL316407:JW5628-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5628-MONOMER BioCyc EcoCyc:DEHYDDEOXPHOSGALACT-ALDOL-MONOMER http://biocyc.org/getid?id=EcoCyc:DEHYDDEOXPHOSGALACT-ALDOL-MONOMER BioCyc MetaCyc:DEHYDDEOXPHOSGALACT-ALDOL-MONOMER http://biocyc.org/getid?id=MetaCyc:DEHYDDEOXPHOSGALACT-ALDOL-MONOMER COG COG0800 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0800 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1016/0014-5793(77)80234-2 http://dx.doi.org/10.1016/0014-5793(77)80234-2 DOI 10.1016/j.bmc.2007.10.043 http://dx.doi.org/10.1016/j.bmc.2007.10.043 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.1.2.21 http://www.genome.jp/dbget-bin/www_bget?EC:4.1.2.21 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 4.1.2.21 http://enzyme.expasy.org/EC/4.1.2.21 EchoBASE EB1667 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1667 EcoGene EG11716 http://www.ecogene.org/geneInfo.php?eg_id=EG11716 EnsemblBacteria AAT48198 http://www.ensemblgenomes.org/id/AAT48198 EnsemblBacteria AAT48198 http://www.ensemblgenomes.org/id/AAT48198 EnsemblBacteria BAE77601 http://www.ensemblgenomes.org/id/BAE77601 EnsemblBacteria BAE77601 http://www.ensemblgenomes.org/id/BAE77601 EnsemblBacteria BAE77601 http://www.ensemblgenomes.org/id/BAE77601 EnsemblBacteria b4477 http://www.ensemblgenomes.org/id/b4477 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008674 GO_process GO:0034194 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034194 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 2847766 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2847766 HOGENOM HOG000233112 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000233112&db=HOGENOM6 InParanoid Q6BF16 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q6BF16 IntEnz 4.1.2.21 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.2.21 InterPro IPR000887 http://www.ebi.ac.uk/interpro/entry/IPR000887 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5628 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5628 KEGG_Gene eco:b4477 http://www.genome.jp/dbget-bin/www_bget?eco:b4477 KEGG_Orthology KO:K01631 http://www.genome.jp/dbget-bin/www_bget?KO:K01631 KEGG_Pathway ko00052 http://www.genome.jp/kegg-bin/show_pathway?ko00052 KEGG_Reaction rn:R01064 http://www.genome.jp/dbget-bin/www_bget?rn:R01064 OMA RQFVEKI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RQFVEKI PDB 2V81 http://www.ebi.ac.uk/pdbe-srv/view/entry/2V81 PDB 2V82 http://www.ebi.ac.uk/pdbe-srv/view/entry/2V82 PDB 4QCC http://www.ebi.ac.uk/pdbe-srv/view/entry/4QCC PDBsum 2V81 http://www.ebi.ac.uk/pdbsum/2V81 PDBsum 2V82 http://www.ebi.ac.uk/pdbsum/2V82 PDBsum 4QCC http://www.ebi.ac.uk/pdbsum/4QCC PSORT swissprot:DGOA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DGOA_ECOLI PSORT-B swissprot:DGOA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DGOA_ECOLI PSORT2 swissprot:DGOA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DGOA_ECOLI Pfam PF01081 http://pfam.xfam.org/family/PF01081 Phobius swissprot:DGOA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DGOA_ECOLI PhylomeDB Q6BF16 http://phylomedb.org/?seqid=Q6BF16 ProteinModelPortal Q6BF16 http://www.proteinmodelportal.org/query/uniprot/Q6BF16 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17981470 http://www.ncbi.nlm.nih.gov/pubmed/17981470 PubMed 324806 http://www.ncbi.nlm.nih.gov/pubmed/324806 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001198722 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001198722 RefSeq YP_026238 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026238 SMR Q6BF16 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q6BF16 STRING 511145.b4477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4477&targetmode=cogs STRING COG0800 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0800&targetmode=cogs UniProtKB DGOA_ECOLI http://www.uniprot.org/uniprot/DGOA_ECOLI UniProtKB-AC Q6BF16 http://www.uniprot.org/uniprot/Q6BF16 charge swissprot:DGOA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DGOA_ECOLI eggNOG COG0800 http://eggnogapi.embl.de/nog_data/html/tree/COG0800 eggNOG ENOG4108RTU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108RTU epestfind swissprot:DGOA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DGOA_ECOLI garnier swissprot:DGOA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DGOA_ECOLI helixturnhelix swissprot:DGOA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DGOA_ECOLI hmoment swissprot:DGOA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DGOA_ECOLI iep swissprot:DGOA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DGOA_ECOLI inforesidue swissprot:DGOA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DGOA_ECOLI octanol swissprot:DGOA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DGOA_ECOLI pepcoil swissprot:DGOA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DGOA_ECOLI pepdigest swissprot:DGOA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DGOA_ECOLI pepinfo swissprot:DGOA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DGOA_ECOLI pepnet swissprot:DGOA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DGOA_ECOLI pepstats swissprot:DGOA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DGOA_ECOLI pepwheel swissprot:DGOA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DGOA_ECOLI pepwindow swissprot:DGOA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DGOA_ECOLI sigcleave swissprot:DGOA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DGOA_ECOLI ## Database ID URL or Descriptions # AltName RCSB_ECOLI Capsular synthesis regulator component B # BioGrid 4260879 3 # CDD cd06170 LuxR_C_like # ENZYME REGULATION RCSB_ECOLI Activity is modulated by phosphorylation and interaction with other transcriptional regulators. Probably up- regulated by YmgA/AriR, and possibly down-regulated by YcgZ, all 3 are connector proteins providing additional signal input into the signaling system. {ECO 0000269|PubMed 19240136, ECO 0000269|PubMed 20952573}. # EcoGene EG10821 rcsB # FUNCTION RCSB_ECOLI Component of the Rcs signaling system, which controls transcription of numerous genes. RcsB is the response regulator that binds to regulatory DNA regions. Can function both in an RcsA-dependent or RcsA-independent manner. The system regulates expression of numerous genes, including genes involved in colanic acid capsule synthesis, biofilm formation, cell division and outer membrane proteins synthesis. Also involved, with GadE, in control of glutamate-dependent acid resistance, and, with BglJ, in derepression of the cryptic bgl operon. The RcsB-BglJ activity is probably independent of RcsB phosphorylation. {ECO 0000255|HAMAP- Rule MF_00981, ECO 0000269|PubMed 10702265, ECO 0000269|PubMed 11309126, ECO 0000269|PubMed 11566985, ECO 0000269|PubMed 13129944, ECO 0000269|PubMed 1597415, ECO 0000269|PubMed 20189963, ECO 0000269|PubMed 20952573}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0001140 transcriptional activator activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding; IDA:EcoCyc. # GO_function GO:0001141 transcriptional repressor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0004871 signal transducer activity; IEA:UniProtKB-HAMAP. # GO_process GO:0000160 phosphorelay signal transduction system; IEA:UniProtKB-HAMAP. # GO_process GO:0006351 transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0031346 positive regulation of cell projection organization; IMP:CACAO. # GO_process GO:0044011 single-species biofilm formation on inanimate substrate; IMP:CACAO. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IMP:EcoCyc. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IMP:EcoCyc. # GO_process GO:0046677 response to antibiotic; IMP:CACAO. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004871 signal transducer activity # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # HAMAP MF_00981 RcsB # INDUCTION RCSB_ECOLI Expression is dependent on the alternate sigma factor, RpoN (PubMed 2404948). Repressed by hydroxyurea. {ECO 0000269|PubMed 20005847, ECO 0000269|PubMed 2404948}. # INTERACTION RCSB_ECOLI P39404 bglJ; NbExp=2; IntAct=EBI-369670, EBI-551429; # IntAct P0DMC7 40 # InterPro IPR000792 Tscrpt_reg_LuxR_C # InterPro IPR001789 Sig_transdc_resp-reg_receiver # InterPro IPR011006 CheY-like_superfamily # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR016032 Sig_transdc_resp-reg_C-effctor # InterPro IPR030864 RcsB # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02022 M00474 RcsC-RcsD-RcsB (capsule synthesis) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # MISCELLANEOUS There is a close linkage between the Rcs and PhoQ/P signaling systems, and both signaling systems respond to certain external divalent cations (zinc and magnesium). {ECO:0000305|PubMed 13129944}. # Organism RCSB_ECOLI Escherichia coli (strain K12) # PDB 5I4C X-ray; 2.00 A; A=1-147 # PIR JV0068 BVECCB # PRINTS PR00038 HTHLUXR # PROSITE PS00622 HTH_LUXR_1 # PROSITE PS50043 HTH_LUXR_2 # PROSITE PS50110 RESPONSE_REGULATORY # PTM RCSB_ECOLI Phosphorylated and activated by RcsD. {ECO 0000305|PubMed 11309126}. # Pfam PF00072 Response_reg # Pfam PF00196 GerE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Transcriptional regulatory protein RcsB {ECO:0000255|HAMAP-Rule MF_00981} # RefSeq NP_416721 NC_000913.3 # RefSeq WP_001061917 NZ_LN832404.1 # SIMILARITY Belongs to the RcsB family. {ECO:0000255|HAMAP- Rule MF_00981}. # SIMILARITY Contains 1 HTH luxR-type DNA-binding domain. {ECO:0000255|HAMAP-Rule MF_00981}. # SIMILARITY Contains 1 response regulatory domain. {ECO:0000255|PROSITE-ProRule PRU00169}. # SMART SM00421 HTH_LUXR # SMART SM00448 REC # SUBUNIT RCSB_ECOLI Interacts with RcsD and RcsA. Homodimer. Can form an heterodimer with the coactivator RcsA, which binds to the RcsAB boxes to promote transcription of RcsA-dependent genes. Can also form a heterodimer with GadE to bind to the GAD box, and with BglJ to bind to the bgl promoter. {ECO 0000255|HAMAP-Rule MF_00981, ECO 0000269|PubMed 10702265, ECO 0000269|PubMed 11566985, ECO 0000269|PubMed 15476819, ECO 0000269|PubMed 1999391, ECO 0000269|PubMed 20189963, ECO 0000269|PubMed 20952573}. # SUPFAM SSF46894 SSF46894 # SUPFAM SSF52172 SSF52172 # eggNOG COG2197 LUCA # eggNOG ENOG41068CG Bacteria BLAST swissprot:RCSB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RCSB_ECOLI COG COG2197 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2197 DOI 10.1016/j.jmb.2004.08.096 http://dx.doi.org/10.1016/j.jmb.2004.08.096 DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2001.02393.x http://dx.doi.org/10.1046/j.1365-2958.2001.02393.x DOI 10.1074/jbc.275.10.7013 http://dx.doi.org/10.1074/jbc.275.10.7013 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/nar/gkq097 http://dx.doi.org/10.1093/nar/gkq097 DOI 10.1101/gad.499409 http://dx.doi.org/10.1101/gad.499409 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00807-10 http://dx.doi.org/10.1128/JB.00807-10 DOI 10.1128/JB.183.20.5870-5876.2001 http://dx.doi.org/10.1128/JB.183.20.5870-5876.2001 DOI 10.1128/JB.185.19.5735-5746.2003 http://dx.doi.org/10.1128/JB.185.19.5735-5746.2003 DOI 10.1271/bbb.65.2364 http://dx.doi.org/10.1271/bbb.65.2364 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M28242 http://www.ebi.ac.uk/ena/data/view/M28242 EMBL S37760 http://www.ebi.ac.uk/ena/data/view/S37760 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0814 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0814 EcoGene EG10821 http://www.ecogene.org/geneInfo.php?eg_id=EG10821 EnsemblBacteria AAC75277 http://www.ensemblgenomes.org/id/AAC75277 EnsemblBacteria AAC75277 http://www.ensemblgenomes.org/id/AAC75277 EnsemblBacteria BAA16000 http://www.ensemblgenomes.org/id/BAA16000 EnsemblBacteria BAA16000 http://www.ensemblgenomes.org/id/BAA16000 EnsemblBacteria BAA16000 http://www.ensemblgenomes.org/id/BAA16000 EnsemblBacteria b2217 http://www.ensemblgenomes.org/id/b2217 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0001140 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001140 GO_function GO:0001141 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001141 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0031346 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031346 GO_process GO:0044011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044011 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 947441 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947441 HAMAP MF_00981 http://hamap.expasy.org/unirule/MF_00981 IntAct P0DMC7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0DMC7* InterPro IPR000792 http://www.ebi.ac.uk/interpro/entry/IPR000792 InterPro IPR001789 http://www.ebi.ac.uk/interpro/entry/IPR001789 InterPro IPR011006 http://www.ebi.ac.uk/interpro/entry/IPR011006 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR016032 http://www.ebi.ac.uk/interpro/entry/IPR016032 InterPro IPR030864 http://www.ebi.ac.uk/interpro/entry/IPR030864 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW2205 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2205 KEGG_Gene eco:b2217 http://www.genome.jp/dbget-bin/www_bget?eco:b2217 KEGG_Orthology KO:K07687 http://www.genome.jp/dbget-bin/www_bget?KO:K07687 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA IEWVNIV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IEWVNIV PDB 5I4C http://www.ebi.ac.uk/pdbe-srv/view/entry/5I4C PDBsum 5I4C http://www.ebi.ac.uk/pdbsum/5I4C PRINTS PR00038 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00038 PROSITE PS00622 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00622 PROSITE PS50043 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50043 PROSITE PS50110 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50110 PSORT swissprot:RCSB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RCSB_ECOLI PSORT-B swissprot:RCSB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RCSB_ECOLI PSORT2 swissprot:RCSB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RCSB_ECOLI Pfam PF00072 http://pfam.xfam.org/family/PF00072 Pfam PF00196 http://pfam.xfam.org/family/PF00196 Phobius swissprot:RCSB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RCSB_ECOLI PhylomeDB P0DMC7 http://phylomedb.org/?seqid=P0DMC7 ProteinModelPortal P0DMC7 http://www.proteinmodelportal.org/query/uniprot/P0DMC7 PubMed 10702265 http://www.ncbi.nlm.nih.gov/pubmed/10702265 PubMed 11309126 http://www.ncbi.nlm.nih.gov/pubmed/11309126 PubMed 11566985 http://www.ncbi.nlm.nih.gov/pubmed/11566985 PubMed 11758943 http://www.ncbi.nlm.nih.gov/pubmed/11758943 PubMed 13129944 http://www.ncbi.nlm.nih.gov/pubmed/13129944 PubMed 15476819 http://www.ncbi.nlm.nih.gov/pubmed/15476819 PubMed 1597415 http://www.ncbi.nlm.nih.gov/pubmed/1597415 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19240136 http://www.ncbi.nlm.nih.gov/pubmed/19240136 PubMed 1999391 http://www.ncbi.nlm.nih.gov/pubmed/1999391 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 20189963 http://www.ncbi.nlm.nih.gov/pubmed/20189963 PubMed 20952573 http://www.ncbi.nlm.nih.gov/pubmed/20952573 PubMed 2404948 http://www.ncbi.nlm.nih.gov/pubmed/2404948 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416721 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416721 RefSeq WP_001061917 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001061917 SMART SM00421 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00421 SMART SM00448 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00448 SMR P0DMC7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0DMC7 STRING 511145.b2217 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2217&targetmode=cogs STRING COG2197 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2197&targetmode=cogs SUPFAM SSF46894 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46894 SUPFAM SSF52172 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52172 UniProtKB RCSB_ECOLI http://www.uniprot.org/uniprot/RCSB_ECOLI UniProtKB-AC P0DMC7 http://www.uniprot.org/uniprot/P0DMC7 charge swissprot:RCSB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RCSB_ECOLI eggNOG COG2197 http://eggnogapi.embl.de/nog_data/html/tree/COG2197 eggNOG ENOG41068CG http://eggnogapi.embl.de/nog_data/html/tree/ENOG41068CG epestfind swissprot:RCSB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RCSB_ECOLI garnier swissprot:RCSB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RCSB_ECOLI helixturnhelix swissprot:RCSB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RCSB_ECOLI hmoment swissprot:RCSB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RCSB_ECOLI iep swissprot:RCSB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RCSB_ECOLI inforesidue swissprot:RCSB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RCSB_ECOLI octanol swissprot:RCSB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RCSB_ECOLI pepcoil swissprot:RCSB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RCSB_ECOLI pepdigest swissprot:RCSB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RCSB_ECOLI pepinfo swissprot:RCSB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RCSB_ECOLI pepnet swissprot:RCSB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RCSB_ECOLI pepstats swissprot:RCSB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RCSB_ECOLI pepwheel swissprot:RCSB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RCSB_ECOLI pepwindow swissprot:RCSB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RCSB_ECOLI sigcleave swissprot:RCSB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RCSB_ECOLI ## Database ID URL or Descriptions # BioGrid 4259807 13 # EcoGene EG13600 prpR # FUNCTION PRPR_ECOLI Involved in the transcriptional regulation of the propionate catabolism operon. # GO_component GO:0005737 cytoplasm; IEA:InterPro. # GO_function GO:0000156 phosphorelay response regulator activity; IEA:InterPro. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0043565 sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0019629 propionate catabolic process, 2-methylcitrate cycle; IEA:InterPro. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.10.60 -; 1. # Gene3D 3.40.50.300 -; 1. # InterPro IPR002078 Sigma_54_int # InterPro IPR002197 HTH_Fis # InterPro IPR003593 AAA+_ATPase # InterPro IPR009057 Homeodomain-like # InterPro IPR010524 Sig_transdc_resp-reg_PrpR_N # InterPro IPR012704 Sig_transdc_resp-reg_PrpR # InterPro IPR025943 Sigma_54_int_dom_ATP-bd_2 # InterPro IPR025944 Sigma_54_int_dom_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko03000 Transcription factors # Organism PRPR_ECOLI Escherichia coli (strain K12) # PATRIC 32115791 VBIEscCol129921_0337 # PDB 2PJU X-ray; 2.10 A; A/B/C/D=2-215 # PIR B64760 B64760 # PROSITE PS00676 SIGMA54_INTERACT_2 # PROSITE PS00688 SIGMA54_INTERACT_3 # PROSITE PS50045 SIGMA54_INTERACT_4 # Pfam PF00158 Sigma54_activat # Pfam PF02954 HTH_8 # Pfam PF06506 PrpR_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PRPR_ECOLI Propionate catabolism operon regulatory protein # RefSeq NP_414864 NC_000913.3 # RefSeq WP_000941041 NZ_LN832404.1 # SIMILARITY Contains 1 sigma-54 factor interaction domain. {ECO:0000255|PROSITE-ProRule PRU00193}. # SMART SM00382 AAA # SUPFAM SSF46689 SSF46689 # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR02329 propionate_PrpR # eggNOG COG1221 LUCA # eggNOG ENOG4108JU7 Bacteria BLAST swissprot:PRPR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PRPR_ECOLI BioCyc ECOL316407:JW0322-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0322-MONOMER BioCyc EcoCyc:G6195-MONOMER http://biocyc.org/getid?id=EcoCyc:G6195-MONOMER COG COG1221 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1221 DIP DIP-10582N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10582N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB3369 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3369 EcoGene EG13600 http://www.ecogene.org/geneInfo.php?eg_id=EG13600 EnsemblBacteria AAC73433 http://www.ensemblgenomes.org/id/AAC73433 EnsemblBacteria AAC73433 http://www.ensemblgenomes.org/id/AAC73433 EnsemblBacteria BAE76113 http://www.ensemblgenomes.org/id/BAE76113 EnsemblBacteria BAE76113 http://www.ensemblgenomes.org/id/BAE76113 EnsemblBacteria BAE76113 http://www.ensemblgenomes.org/id/BAE76113 EnsemblBacteria b0330 http://www.ensemblgenomes.org/id/b0330 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000156 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000156 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0019629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019629 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 944987 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944987 HOGENOM HOG000058487 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000058487&db=HOGENOM6 InParanoid P77743 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77743 IntAct P77743 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77743* InterPro IPR002078 http://www.ebi.ac.uk/interpro/entry/IPR002078 InterPro IPR002197 http://www.ebi.ac.uk/interpro/entry/IPR002197 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR010524 http://www.ebi.ac.uk/interpro/entry/IPR010524 InterPro IPR012704 http://www.ebi.ac.uk/interpro/entry/IPR012704 InterPro IPR025943 http://www.ebi.ac.uk/interpro/entry/IPR025943 InterPro IPR025944 http://www.ebi.ac.uk/interpro/entry/IPR025944 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW0322 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0322 KEGG_Gene eco:b0330 http://www.genome.jp/dbget-bin/www_bget?eco:b0330 KEGG_Orthology KO:K02688 http://www.genome.jp/dbget-bin/www_bget?KO:K02688 OMA IMLYARS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IMLYARS PDB 2PJU http://www.ebi.ac.uk/pdbe-srv/view/entry/2PJU PDBsum 2PJU http://www.ebi.ac.uk/pdbsum/2PJU PROSITE PS00676 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00676 PROSITE PS00688 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00688 PROSITE PS50045 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50045 PSORT swissprot:PRPR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PRPR_ECOLI PSORT-B swissprot:PRPR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PRPR_ECOLI PSORT2 swissprot:PRPR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PRPR_ECOLI Pfam PF00158 http://pfam.xfam.org/family/PF00158 Pfam PF02954 http://pfam.xfam.org/family/PF02954 Pfam PF06506 http://pfam.xfam.org/family/PF06506 Phobius swissprot:PRPR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PRPR_ECOLI PhylomeDB P77743 http://phylomedb.org/?seqid=P77743 ProteinModelPortal P77743 http://www.proteinmodelportal.org/query/uniprot/P77743 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414864 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414864 RefSeq WP_000941041 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000941041 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P77743 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77743 STRING 511145.b0330 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0330&targetmode=cogs STRING COG1221 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1221&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR02329 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02329 UniProtKB PRPR_ECOLI http://www.uniprot.org/uniprot/PRPR_ECOLI UniProtKB-AC P77743 http://www.uniprot.org/uniprot/P77743 charge swissprot:PRPR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PRPR_ECOLI eggNOG COG1221 http://eggnogapi.embl.de/nog_data/html/tree/COG1221 eggNOG ENOG4108JU7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108JU7 epestfind swissprot:PRPR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PRPR_ECOLI garnier swissprot:PRPR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PRPR_ECOLI helixturnhelix swissprot:PRPR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PRPR_ECOLI hmoment swissprot:PRPR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PRPR_ECOLI iep swissprot:PRPR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PRPR_ECOLI inforesidue swissprot:PRPR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PRPR_ECOLI octanol swissprot:PRPR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PRPR_ECOLI pepcoil swissprot:PRPR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PRPR_ECOLI pepdigest swissprot:PRPR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PRPR_ECOLI pepinfo swissprot:PRPR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PRPR_ECOLI pepnet swissprot:PRPR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PRPR_ECOLI pepstats swissprot:PRPR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PRPR_ECOLI pepwheel swissprot:PRPR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PRPR_ECOLI pepwindow swissprot:PRPR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PRPR_ECOLI sigcleave swissprot:PRPR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PRPR_ECOLI ## Database ID URL or Descriptions # BioGrid 4262988 188 # EcoGene EG13709 elfA # FUNCTION ELFA_ECOLI Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. ElfA is the major fimbrial subunit produced by this operon. {ECO 0000269|PubMed 20345943}. # GO_component GO:0009289 pilus; IDA:EcoCyc. # GO_process GO:0043709 cell adhesion involved in single-species biofilm formation; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0007155 cell adhesion # Gene3D 2.60.40.1090 -; 1. # INDUCTION Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression. {ECO:0000269|PubMed 20345943}. # InterPro IPR000259 Adhesion_dom_fimbrial # InterPro IPR008966 Adhesion_dom # MISCELLANEOUS The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed. {ECO:0000305|PubMed 20345943}. # Organism ELFA_ECOLI Escherichia coli (strain K12) # PATRIC 32117095 VBIEscCol129921_0972 # PIR A64834 A64834 # Pfam PF00419 Fimbrial # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ELFA_ECOLI Fimbrial subunit ElfA # RefSeq NP_415458 NC_000913.3 # RefSeq WP_000750293 NZ_LN832404.1 # SIMILARITY Belongs to the fimbrial protein family. {ECO 0000305}. # SUBCELLULAR LOCATION ELFA_ECOLI Fimbrium {ECO 0000269|PubMed 20345943}. # SUPFAM SSF49401 SSF49401 # eggNOG ENOG41071VI Bacteria # eggNOG ENOG410Y4ID LUCA BLAST swissprot:ELFA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ELFA_ECOLI BioCyc ECOL316407:JW5122-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5122-MONOMER BioCyc EcoCyc:G6480-MONOMER http://biocyc.org/getid?id=EcoCyc:G6480-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1462-2920.2010.02202.x http://dx.doi.org/10.1111/j.1462-2920.2010.02202.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3473 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3473 EcoGene EG13709 http://www.ecogene.org/geneInfo.php?eg_id=EG13709 EnsemblBacteria AAC74024 http://www.ensemblgenomes.org/id/AAC74024 EnsemblBacteria AAC74024 http://www.ensemblgenomes.org/id/AAC74024 EnsemblBacteria BAA35693 http://www.ensemblgenomes.org/id/BAA35693 EnsemblBacteria BAA35693 http://www.ensemblgenomes.org/id/BAA35693 EnsemblBacteria BAA35693 http://www.ensemblgenomes.org/id/BAA35693 EnsemblBacteria b0938 http://www.ensemblgenomes.org/id/b0938 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009289 GO_process GO:0043709 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043709 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 Gene3D 2.60.40.1090 http://www.cathdb.info/version/latest/superfamily/2.60.40.1090 GeneID 948306 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948306 HOGENOM HOG000260127 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260127&db=HOGENOM6 InParanoid P75855 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75855 IntAct P75855 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75855* InterPro IPR000259 http://www.ebi.ac.uk/interpro/entry/IPR000259 InterPro IPR008966 http://www.ebi.ac.uk/interpro/entry/IPR008966 KEGG_Gene ecj:JW5122 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5122 KEGG_Gene eco:b0938 http://www.genome.jp/dbget-bin/www_bget?eco:b0938 OMA APACTIA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=APACTIA PSORT swissprot:ELFA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ELFA_ECOLI PSORT-B swissprot:ELFA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ELFA_ECOLI PSORT2 swissprot:ELFA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ELFA_ECOLI Pfam PF00419 http://pfam.xfam.org/family/PF00419 Phobius swissprot:ELFA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ELFA_ECOLI PhylomeDB P75855 http://phylomedb.org/?seqid=P75855 ProteinModelPortal P75855 http://www.proteinmodelportal.org/query/uniprot/P75855 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20345943 http://www.ncbi.nlm.nih.gov/pubmed/20345943 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415458 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415458 RefSeq WP_000750293 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000750293 SMR P75855 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75855 STRING 511145.b0938 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0938&targetmode=cogs SUPFAM SSF49401 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49401 UniProtKB ELFA_ECOLI http://www.uniprot.org/uniprot/ELFA_ECOLI UniProtKB-AC P75855 http://www.uniprot.org/uniprot/P75855 charge swissprot:ELFA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ELFA_ECOLI eggNOG ENOG41071VI http://eggnogapi.embl.de/nog_data/html/tree/ENOG41071VI eggNOG ENOG410Y4ID http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y4ID epestfind swissprot:ELFA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ELFA_ECOLI garnier swissprot:ELFA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ELFA_ECOLI helixturnhelix swissprot:ELFA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ELFA_ECOLI hmoment swissprot:ELFA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ELFA_ECOLI iep swissprot:ELFA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ELFA_ECOLI inforesidue swissprot:ELFA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ELFA_ECOLI octanol swissprot:ELFA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ELFA_ECOLI pepcoil swissprot:ELFA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ELFA_ECOLI pepdigest swissprot:ELFA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ELFA_ECOLI pepinfo swissprot:ELFA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ELFA_ECOLI pepnet swissprot:ELFA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ELFA_ECOLI pepstats swissprot:ELFA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ELFA_ECOLI pepwheel swissprot:ELFA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ELFA_ECOLI pepwindow swissprot:ELFA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ELFA_ECOLI sigcleave swissprot:ELFA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ELFA_ECOLI ## Database ID URL or Descriptions # AltName NFSA_ECOLI Modulator of drug activity A # BIOPHYSICOCHEMICAL PROPERTIES NFSA_ECOLI Kinetic parameters KM=11 uM for NADPH {ECO 0000269|PubMed 8755878}; KM=5.5 uM for nitrofurazone {ECO 0000269|PubMed 8755878}; # BioGrid 4259991 10 # CATALYTIC ACTIVITY An oxidized nitroaromatic compound + NADPH = a reduced nitroaromatic compound + NADP(+). {ECO:0000269|PubMed 8755878}. # CDD cd02146 NfsA_FRP # COFACTOR NFSA_ECOLI Name=FMN; Xref=ChEBI CHEBI 58210; Evidence={ECO 0000269|PubMed 11034992, ECO 0000269|PubMed 8755878}; Note=Binds 1 FMN per monomer. {ECO 0000269|PubMed 11034992}; # DrugBank DB00698 Nitrofurantoin # EcoGene EG11261 nfsA # FUNCTION NFSA_ECOLI Catalyzes the reduction of nitroaromatic compounds using NADPH. Has a broad electron acceptor specificity. Reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer product. Major oxygen-insensitive nitroreductase in E.coli. {ECO 0000269|PubMed 8755878}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0010181 FMN binding; IDA:EcoCyc. # GO_function GO:0016657 oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor; IDA:EcoCyc. # GO_function GO:0034567 chromate reductase activity; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.109.10 -; 1. # INTERACTION NFSA_ECOLI P28630 holA; NbExp=3; IntAct=EBI-1120624, EBI-549153; # IntAct P17117 5 # InterPro IPR000415 Nitroreductase-like # InterPro IPR016446 Flavin_OxRdtase_Frp # InterPro IPR029479 Nitroreductase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00633 Nitrotoluene degradation # Organism NFSA_ECOLI Escherichia coli (strain K12) # PATRIC 32116907 VBIEscCol129921_0879 # PDB 1F5V X-ray; 1.70 A; A/B=1-240 # PIR I80318 I80318 # PIRSF PIRSF005426 Frp # Pfam PF00881 Nitroreductase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Oxygen-insensitive NADPH nitroreductase {ECO 0000305} # RefSeq NP_415372 NC_000913.3 # RefSeq WP_000189159 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA33867.1; Type=Frameshift; Positions=155, 161, 187; Evidence={ECO 0000305}; # SIMILARITY Belongs to the flavin oxidoreductase frp family. {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 11034992}. # SUPFAM SSF55469 SSF55469 # eggNOG COG0778 LUCA # eggNOG ENOG4108DBC Bacteria BLAST swissprot:NFSA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NFSA_ECOLI BioCyc ECOL316407:JW0835-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0835-MONOMER BioCyc EcoCyc:EG11261-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11261-MONOMER BioCyc MetaCyc:EG11261-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11261-MONOMER COG COG0778 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0778 DIP DIP-10334N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10334N DOI 10.1007/BF02464894 http://dx.doi.org/10.1007/BF02464894 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.92.19.8950 http://dx.doi.org/10.1073/pnas.92.19.8950 DOI 10.1074/jbc.M002617200 http://dx.doi.org/10.1074/jbc.M002617200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB00698 http://www.drugbank.ca/drugs/DB00698 EC_number EC:1.-.-.- {ECO:0000269|PubMed:8755878} http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- {ECO:0000269|PubMed:8755878} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D38308 http://www.ebi.ac.uk/ena/data/view/D38308 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18655 http://www.ebi.ac.uk/ena/data/view/U18655 EMBL X15859 http://www.ebi.ac.uk/ena/data/view/X15859 ENZYME 1.-.-.- {ECO:0000269|PubMed:8755878} http://enzyme.expasy.org/EC/1.-.-.- {ECO:0000269|PubMed:8755878} EchoBASE EB1241 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1241 EcoGene EG11261 http://www.ecogene.org/geneInfo.php?eg_id=EG11261 EnsemblBacteria AAC73938 http://www.ensemblgenomes.org/id/AAC73938 EnsemblBacteria AAC73938 http://www.ensemblgenomes.org/id/AAC73938 EnsemblBacteria BAA35562 http://www.ensemblgenomes.org/id/BAA35562 EnsemblBacteria BAA35562 http://www.ensemblgenomes.org/id/BAA35562 EnsemblBacteria BAA35562 http://www.ensemblgenomes.org/id/BAA35562 EnsemblBacteria b0851 http://www.ensemblgenomes.org/id/b0851 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0010181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010181 GO_function GO:0016657 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016657 GO_function GO:0034567 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034567 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.109.10 http://www.cathdb.info/version/latest/superfamily/3.40.109.10 GeneID 945483 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945483 HOGENOM HOG000272869 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000272869&db=HOGENOM6 InParanoid P17117 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P17117 IntAct P17117 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P17117* IntEnz 1.-.-.- {ECO:0000269|PubMed:8755878} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.-.-.- {ECO:0000269|PubMed:8755878} InterPro IPR000415 http://www.ebi.ac.uk/interpro/entry/IPR000415 InterPro IPR016446 http://www.ebi.ac.uk/interpro/entry/IPR016446 InterPro IPR029479 http://www.ebi.ac.uk/interpro/entry/IPR029479 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0835 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0835 KEGG_Gene eco:b0851 http://www.genome.jp/dbget-bin/www_bget?eco:b0851 KEGG_Orthology KO:K10678 http://www.genome.jp/dbget-bin/www_bget?KO:K10678 KEGG_Pathway ko00633 http://www.genome.jp/kegg-bin/show_pathway?ko00633 KEGG_Reaction rn:R08014 http://www.genome.jp/dbget-bin/www_bget?rn:R08014 KEGG_Reaction rn:R08017 http://www.genome.jp/dbget-bin/www_bget?rn:R08017 KEGG_Reaction rn:R08042 http://www.genome.jp/dbget-bin/www_bget?rn:R08042 OMA AYYKERS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AYYKERS PDB 1F5V http://www.ebi.ac.uk/pdbe-srv/view/entry/1F5V PDBsum 1F5V http://www.ebi.ac.uk/pdbsum/1F5V PSORT swissprot:NFSA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NFSA_ECOLI PSORT-B swissprot:NFSA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NFSA_ECOLI PSORT2 swissprot:NFSA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NFSA_ECOLI Pfam PF00881 http://pfam.xfam.org/family/PF00881 Phobius swissprot:NFSA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NFSA_ECOLI PhylomeDB P17117 http://phylomedb.org/?seqid=P17117 ProteinModelPortal P17117 http://www.proteinmodelportal.org/query/uniprot/P17117 PubMed 11034992 http://www.ncbi.nlm.nih.gov/pubmed/11034992 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2570347 http://www.ncbi.nlm.nih.gov/pubmed/2570347 PubMed 7568050 http://www.ncbi.nlm.nih.gov/pubmed/7568050 PubMed 8755878 http://www.ncbi.nlm.nih.gov/pubmed/8755878 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9440535 http://www.ncbi.nlm.nih.gov/pubmed/9440535 RefSeq NP_415372 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415372 RefSeq WP_000189159 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000189159 SMR P17117 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P17117 STRING 511145.b0851 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0851&targetmode=cogs STRING COG0778 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0778&targetmode=cogs SUPFAM SSF55469 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55469 UniProtKB NFSA_ECOLI http://www.uniprot.org/uniprot/NFSA_ECOLI UniProtKB-AC P17117 http://www.uniprot.org/uniprot/P17117 charge swissprot:NFSA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NFSA_ECOLI eggNOG COG0778 http://eggnogapi.embl.de/nog_data/html/tree/COG0778 eggNOG ENOG4108DBC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108DBC epestfind swissprot:NFSA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NFSA_ECOLI garnier swissprot:NFSA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NFSA_ECOLI helixturnhelix swissprot:NFSA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NFSA_ECOLI hmoment swissprot:NFSA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NFSA_ECOLI iep swissprot:NFSA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NFSA_ECOLI inforesidue swissprot:NFSA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NFSA_ECOLI octanol swissprot:NFSA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NFSA_ECOLI pepcoil swissprot:NFSA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NFSA_ECOLI pepdigest swissprot:NFSA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NFSA_ECOLI pepinfo swissprot:NFSA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NFSA_ECOLI pepnet swissprot:NFSA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NFSA_ECOLI pepstats swissprot:NFSA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NFSA_ECOLI pepwheel swissprot:NFSA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NFSA_ECOLI pepwindow swissprot:NFSA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NFSA_ECOLI sigcleave swissprot:NFSA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NFSA_ECOLI ## Database ID URL or Descriptions # AltName YBDL_ECOLI Methionine-oxo-acid transaminase # BRENDA 2.6.1.88 2026 # BioGrid 4260981 13 # CATALYTIC ACTIVITY L-methionine + a 2-oxo acid = 2-oxo-4- methylthiobutanoate + an L-amino acid. {ECO:0000269|PubMed 15280032}. # COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI 597326; # EcoGene EG13531 ybdL # FUNCTION YBDL_ECOLI Shows aminotransferase activity with methionine and histidine as substrates, and to a lesser extent also with phenylalanine. {ECO 0000269|PubMed 15280032}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0010326 methionine-oxo-acid transaminase activity; IDA:EcoCyc. # GO_function GO:0030170 pyridoxal phosphate binding; IDA:EcoCyc. # GO_process GO:0009058 biosynthetic process; IEA:InterPro. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.640.10 -; 1. # Gene3D 3.90.1150.10 -; 1. # INTERACTION YBDL_ECOLI P69441 adk; NbExp=2; IntAct=EBI-543661, EBI-543592; P0ABI8 cyoB; NbExp=3; IntAct=EBI-543661, EBI-2932021; P68646 fixX; NbExp=3; IntAct=EBI-543661, EBI-1113234; # IntAct P77806 14 # InterPro IPR004839 Aminotransferase_I/II # InterPro IPR015421 PyrdxlP-dep_Trfase_major_sub1 # InterPro IPR015422 PyrdxlP-dep_Trfase_major_sub2 # InterPro IPR015424 PyrdxlP-dep_Trfase # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01007 Amino acid related enzymes # Organism YBDL_ECOLI Escherichia coli (strain K12) # PATRIC 32116378 VBIEscCol129921_0629 # PDB 1U08 X-ray; 2.35 A; A/B=1-386 # PIR F64793 F64793 # Pfam PF00155 Aminotran_1_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBDL_ECOLI Methionine aminotransferase # RefSeq NP_415133 NC_000913.3 # RefSeq WP_000183907 NZ_LN832404.1 # SIMILARITY Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. {ECO 0000305}. # SUBCELLULAR LOCATION YBDL_ECOLI Cytoplasm {ECO 0000250}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 15280032}. # SUPFAM SSF53383 SSF53383 # eggNOG COG0436 LUCA # eggNOG ENOG4105CHM Bacteria BLAST swissprot:YBDL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBDL_ECOLI BioCyc ECOL316407:JW0593-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0593-MONOMER BioCyc EcoCyc:G6329-MONOMER http://biocyc.org/getid?id=EcoCyc:G6329-MONOMER BioCyc MetaCyc:G6329-MONOMER http://biocyc.org/getid?id=MetaCyc:G6329-MONOMER COG COG0436 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0436 DIP DIP-11350N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11350N DOI 10.1016/j.febslet.2004.06.075 http://dx.doi.org/10.1016/j.febslet.2004.06.075 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.6.1.88 http://www.genome.jp/dbget-bin/www_bget?EC:2.6.1.88 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 ENZYME 2.6.1.88 http://enzyme.expasy.org/EC/2.6.1.88 EchoBASE EB3302 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3302 EcoGene EG13531 http://www.ecogene.org/geneInfo.php?eg_id=EG13531 EnsemblBacteria AAC73701 http://www.ensemblgenomes.org/id/AAC73701 EnsemblBacteria AAC73701 http://www.ensemblgenomes.org/id/AAC73701 EnsemblBacteria BAA35230 http://www.ensemblgenomes.org/id/BAA35230 EnsemblBacteria BAA35230 http://www.ensemblgenomes.org/id/BAA35230 EnsemblBacteria BAA35230 http://www.ensemblgenomes.org/id/BAA35230 EnsemblBacteria b0600 http://www.ensemblgenomes.org/id/b0600 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0010326 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010326 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.640.10 http://www.cathdb.info/version/latest/superfamily/3.40.640.10 Gene3D 3.90.1150.10 http://www.cathdb.info/version/latest/superfamily/3.90.1150.10 GeneID 945211 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945211 HOGENOM HOG000223045 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000223045&db=HOGENOM6 InParanoid P77806 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77806 IntAct P77806 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77806* IntEnz 2.6.1.88 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.6.1.88 InterPro IPR004839 http://www.ebi.ac.uk/interpro/entry/IPR004839 InterPro IPR015421 http://www.ebi.ac.uk/interpro/entry/IPR015421 InterPro IPR015422 http://www.ebi.ac.uk/interpro/entry/IPR015422 InterPro IPR015424 http://www.ebi.ac.uk/interpro/entry/IPR015424 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Gene ecj:JW0593 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0593 KEGG_Gene eco:b0600 http://www.genome.jp/dbget-bin/www_bget?eco:b0600 KEGG_Orthology KO:K14287 http://www.genome.jp/dbget-bin/www_bget?KO:K14287 MINT MINT-1306557 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1306557 OMA SQGANQY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SQGANQY PDB 1U08 http://www.ebi.ac.uk/pdbe-srv/view/entry/1U08 PDBsum 1U08 http://www.ebi.ac.uk/pdbsum/1U08 PSORT swissprot:YBDL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBDL_ECOLI PSORT-B swissprot:YBDL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBDL_ECOLI PSORT2 swissprot:YBDL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBDL_ECOLI Pfam PF00155 http://pfam.xfam.org/family/PF00155 Phobius swissprot:YBDL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBDL_ECOLI PhylomeDB P77806 http://phylomedb.org/?seqid=P77806 ProteinModelPortal P77806 http://www.proteinmodelportal.org/query/uniprot/P77806 PubMed 15280032 http://www.ncbi.nlm.nih.gov/pubmed/15280032 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415133 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415133 RefSeq WP_000183907 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000183907 SMR P77806 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77806 STRING 511145.b0600 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0600&targetmode=cogs STRING COG0436 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0436&targetmode=cogs SUPFAM SSF53383 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53383 UniProtKB YBDL_ECOLI http://www.uniprot.org/uniprot/YBDL_ECOLI UniProtKB-AC P77806 http://www.uniprot.org/uniprot/P77806 charge swissprot:YBDL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBDL_ECOLI eggNOG COG0436 http://eggnogapi.embl.de/nog_data/html/tree/COG0436 eggNOG ENOG4105CHM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CHM epestfind swissprot:YBDL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBDL_ECOLI garnier swissprot:YBDL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBDL_ECOLI helixturnhelix swissprot:YBDL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBDL_ECOLI hmoment swissprot:YBDL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBDL_ECOLI iep swissprot:YBDL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBDL_ECOLI inforesidue swissprot:YBDL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBDL_ECOLI octanol swissprot:YBDL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBDL_ECOLI pepcoil swissprot:YBDL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBDL_ECOLI pepdigest swissprot:YBDL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBDL_ECOLI pepinfo swissprot:YBDL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBDL_ECOLI pepnet swissprot:YBDL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBDL_ECOLI pepstats swissprot:YBDL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBDL_ECOLI pepwheel swissprot:YBDL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBDL_ECOLI pepwindow swissprot:YBDL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBDL_ECOLI sigcleave swissprot:YBDL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBDL_ECOLI ## Database ID URL or Descriptions # AltName IDNR_ECOLI L-idonate regulatory protein # BioGrid 4262722 6 # CDD cd01392 HTH_LacI # EcoGene EG12538 idnR # FUNCTION IDNR_ECOLI Idn operon regulator. May repress gntKU and gntT genes when growing on L-idonate. {ECO 0000269|PubMed 9658018}. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0019521 D-gluconate metabolic process; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.260.40 -; 1. # IntAct P39343 3 # InterPro IPR000843 HTH_LacI # InterPro IPR010982 Lambda_DNA-bd_dom # InterPro IPR028082 Peripla_BP_I # KEGG_Brite ko03000 Transcription factors # Organism IDNR_ECOLI Escherichia coli (strain K12) # PATRIC 32124101 VBIEscCol129921_4395 # PIR S56490 S56490 # PROSITE PS00356 HTH_LACI_1 # PROSITE PS50932 HTH_LACI_2 # Pfam PF00356 LacI # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName IDNR_ECOLI HTH-type transcriptional regulator IdnR # RefSeq NP_418685 NC_000913.3 # RefSeq WP_001309159 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lacI-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00111}. # SMART SM00354 HTH_LACI # SUPFAM SSF47413 SSF47413 # SUPFAM SSF53822 SSF53822 # eggNOG ENOG4105K2J Bacteria # eggNOG ENOG410ZETB LUCA BLAST swissprot:IDNR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:IDNR_ECOLI BioCyc ECOL316407:JW4221-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4221-MONOMER BioCyc EcoCyc:G7891-MONOMER http://biocyc.org/getid?id=EcoCyc:G7891-MONOMER COG COG1609 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1609 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2427 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2427 EcoGene EG12538 http://www.ecogene.org/geneInfo.php?eg_id=EG12538 EnsemblBacteria AAC77221 http://www.ensemblgenomes.org/id/AAC77221 EnsemblBacteria AAC77221 http://www.ensemblgenomes.org/id/AAC77221 EnsemblBacteria BAE78261 http://www.ensemblgenomes.org/id/BAE78261 EnsemblBacteria BAE78261 http://www.ensemblgenomes.org/id/BAE78261 EnsemblBacteria BAE78261 http://www.ensemblgenomes.org/id/BAE78261 EnsemblBacteria b4264 http://www.ensemblgenomes.org/id/b4264 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0019521 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019521 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.260.40 http://www.cathdb.info/version/latest/superfamily/1.10.260.40 GeneID 949058 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949058 HOGENOM HOG000220181 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220181&db=HOGENOM6 InParanoid P39343 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39343 IntAct P39343 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39343* InterPro IPR000843 http://www.ebi.ac.uk/interpro/entry/IPR000843 InterPro IPR010982 http://www.ebi.ac.uk/interpro/entry/IPR010982 InterPro IPR028082 http://www.ebi.ac.uk/interpro/entry/IPR028082 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW4221 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4221 KEGG_Gene eco:b4264 http://www.genome.jp/dbget-bin/www_bget?eco:b4264 KEGG_Orthology KO:K06146 http://www.genome.jp/dbget-bin/www_bget?KO:K06146 OMA IVCANDL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IVCANDL PROSITE PS00356 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00356 PROSITE PS50932 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50932 PSORT swissprot:IDNR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:IDNR_ECOLI PSORT-B swissprot:IDNR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:IDNR_ECOLI PSORT2 swissprot:IDNR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:IDNR_ECOLI Pfam PF00356 http://pfam.xfam.org/family/PF00356 Phobius swissprot:IDNR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:IDNR_ECOLI PhylomeDB P39343 http://phylomedb.org/?seqid=P39343 ProteinModelPortal P39343 http://www.proteinmodelportal.org/query/uniprot/P39343 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9658018 http://www.ncbi.nlm.nih.gov/pubmed/9658018 RefSeq NP_418685 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418685 RefSeq WP_001309159 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001309159 SMART SM00354 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00354 STRING 511145.b4264 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4264&targetmode=cogs STRING COG1609 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1609&targetmode=cogs SUPFAM SSF47413 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47413 SUPFAM SSF53822 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822 UniProtKB IDNR_ECOLI http://www.uniprot.org/uniprot/IDNR_ECOLI UniProtKB-AC P39343 http://www.uniprot.org/uniprot/P39343 charge swissprot:IDNR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:IDNR_ECOLI eggNOG ENOG4105K2J http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K2J eggNOG ENOG410ZETB http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZETB epestfind swissprot:IDNR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:IDNR_ECOLI garnier swissprot:IDNR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:IDNR_ECOLI helixturnhelix swissprot:IDNR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:IDNR_ECOLI hmoment swissprot:IDNR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:IDNR_ECOLI iep swissprot:IDNR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:IDNR_ECOLI inforesidue swissprot:IDNR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:IDNR_ECOLI octanol swissprot:IDNR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:IDNR_ECOLI pepcoil swissprot:IDNR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:IDNR_ECOLI pepdigest swissprot:IDNR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:IDNR_ECOLI pepinfo swissprot:IDNR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:IDNR_ECOLI pepnet swissprot:IDNR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:IDNR_ECOLI pepstats swissprot:IDNR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:IDNR_ECOLI pepwheel swissprot:IDNR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:IDNR_ECOLI pepwindow swissprot:IDNR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:IDNR_ECOLI sigcleave swissprot:IDNR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:IDNR_ECOLI ## Database ID URL or Descriptions # BioGrid 4261172 17 # EcoGene EG14216 hyfH # FUNCTION HYFH_ECOLI Probable electron transfer protein for hydrogenase 4. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0055114 oxidation-reduction process; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # InterPro IPR017896 4Fe4S_Fe-S-bd # InterPro IPR017900 4Fe4S_Fe_S_CS # Organism HYFH_ECOLI Escherichia coli (strain K12) # PATRIC 32120363 VBIEscCol129921_2584 # PIR G65024 G65024 # PROSITE PS00198 4FE4S_FER_1; 2 # PROSITE PS51379 4FE4S_FER_2; 2 # Pfam PF12838 Fer4_7 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HYFH_ECOLI Hydrogenase-4 component H # RefSeq NP_416983 NC_000913.3 # RefSeq WP_000916055 NZ_LN832404.1 # SIMILARITY Contains 2 4Fe-4S ferredoxin-type domains. {ECO:0000255|PROSITE-ProRule PRU00711}. # TCDB 3.D.1.9 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family # eggNOG COG1143 LUCA BLAST swissprot:HYFH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HYFH_ECOLI BioCyc ECOL316407:JW2473-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2473-MONOMER BioCyc EcoCyc:MONOMER0-144 http://biocyc.org/getid?id=EcoCyc:MONOMER0-144 COG COG1143 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1143 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M63654 http://www.ebi.ac.uk/ena/data/view/M63654 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3968 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3968 EcoGene EG14216 http://www.ecogene.org/geneInfo.php?eg_id=EG14216 EnsemblBacteria AAC75541 http://www.ensemblgenomes.org/id/AAC75541 EnsemblBacteria AAC75541 http://www.ensemblgenomes.org/id/AAC75541 EnsemblBacteria BAA16376 http://www.ensemblgenomes.org/id/BAA16376 EnsemblBacteria BAA16376 http://www.ensemblgenomes.org/id/BAA16376 EnsemblBacteria BAA16376 http://www.ensemblgenomes.org/id/BAA16376 EnsemblBacteria b2488 http://www.ensemblgenomes.org/id/b2488 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0055114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 946965 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946965 HOGENOM HOG000278697 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278697&db=HOGENOM6 InParanoid P77423 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77423 InterPro IPR017896 http://www.ebi.ac.uk/interpro/entry/IPR017896 InterPro IPR017900 http://www.ebi.ac.uk/interpro/entry/IPR017900 KEGG_Gene ecj:JW2473 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2473 KEGG_Gene eco:b2488 http://www.genome.jp/dbget-bin/www_bget?eco:b2488 KEGG_Orthology KO:K12143 http://www.genome.jp/dbget-bin/www_bget?KO:K12143 OMA MACPANA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MACPANA PROSITE PS00198 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00198 PROSITE PS51379 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51379 PSORT swissprot:HYFH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HYFH_ECOLI PSORT-B swissprot:HYFH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HYFH_ECOLI PSORT2 swissprot:HYFH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HYFH_ECOLI Pfam PF12838 http://pfam.xfam.org/family/PF12838 Phobius swissprot:HYFH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HYFH_ECOLI PhylomeDB P77423 http://phylomedb.org/?seqid=P77423 ProteinModelPortal P77423 http://www.proteinmodelportal.org/query/uniprot/P77423 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416983 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416983 RefSeq WP_000916055 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000916055 SMR P77423 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77423 STRING 511145.b2488 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2488&targetmode=cogs STRING COG1143 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1143&targetmode=cogs TCDB 3.D.1.9 http://www.tcdb.org/search/result.php?tc=3.D.1.9 UniProtKB HYFH_ECOLI http://www.uniprot.org/uniprot/HYFH_ECOLI UniProtKB-AC P77423 http://www.uniprot.org/uniprot/P77423 charge swissprot:HYFH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HYFH_ECOLI eggNOG COG1143 http://eggnogapi.embl.de/nog_data/html/tree/COG1143 epestfind swissprot:HYFH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HYFH_ECOLI garnier swissprot:HYFH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HYFH_ECOLI helixturnhelix swissprot:HYFH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HYFH_ECOLI hmoment swissprot:HYFH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HYFH_ECOLI iep swissprot:HYFH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HYFH_ECOLI inforesidue swissprot:HYFH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HYFH_ECOLI octanol swissprot:HYFH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HYFH_ECOLI pepcoil swissprot:HYFH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HYFH_ECOLI pepdigest swissprot:HYFH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HYFH_ECOLI pepinfo swissprot:HYFH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HYFH_ECOLI pepnet swissprot:HYFH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HYFH_ECOLI pepstats swissprot:HYFH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HYFH_ECOLI pepwheel swissprot:HYFH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HYFH_ECOLI pepwindow swissprot:HYFH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HYFH_ECOLI sigcleave swissprot:HYFH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HYFH_ECOLI ## Database ID URL or Descriptions # BioGrid 4262919 12 # EcoGene EG12213 yhhM # InterPro IPR019635 DUF2500 # Organism YHHM_ECOLI Escherichia coli (strain K12) # PATRIC 32122378 VBIEscCol129921_3566 # PIR S47686 S47686 # Pfam PF10694 DUF2500 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHHM_ECOLI Uncharacterized protein YhhM # RefSeq NP_417924 NC_000913.3 # RefSeq WP_000042895 NZ_LN832404.1 BLAST swissprot:YHHM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHHM_ECOLI BioCyc ECOL316407:JW3432-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3432-MONOMER BioCyc EcoCyc:EG12213-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12213-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2127 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2127 EcoGene EG12213 http://www.ecogene.org/geneInfo.php?eg_id=EG12213 EnsemblBacteria AAC76492 http://www.ensemblgenomes.org/id/AAC76492 EnsemblBacteria AAC76492 http://www.ensemblgenomes.org/id/AAC76492 EnsemblBacteria BAE77826 http://www.ensemblgenomes.org/id/BAE77826 EnsemblBacteria BAE77826 http://www.ensemblgenomes.org/id/BAE77826 EnsemblBacteria BAE77826 http://www.ensemblgenomes.org/id/BAE77826 EnsemblBacteria b3467 http://www.ensemblgenomes.org/id/b3467 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947975 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947975 HOGENOM HOG000125697 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125697&db=HOGENOM6 IntAct P37615 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37615* InterPro IPR019635 http://www.ebi.ac.uk/interpro/entry/IPR019635 KEGG_Gene ecj:JW3432 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3432 KEGG_Gene eco:b3467 http://www.genome.jp/dbget-bin/www_bget?eco:b3467 OMA YHQLTVG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YHQLTVG PSORT swissprot:YHHM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHHM_ECOLI PSORT-B swissprot:YHHM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHHM_ECOLI PSORT2 swissprot:YHHM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHHM_ECOLI Pfam PF10694 http://pfam.xfam.org/family/PF10694 Phobius swissprot:YHHM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHHM_ECOLI ProteinModelPortal P37615 http://www.proteinmodelportal.org/query/uniprot/P37615 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417924 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417924 RefSeq WP_000042895 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000042895 SMR P37615 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37615 STRING 511145.b3467 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3467&targetmode=cogs UniProtKB YHHM_ECOLI http://www.uniprot.org/uniprot/YHHM_ECOLI UniProtKB-AC P37615 http://www.uniprot.org/uniprot/P37615 charge swissprot:YHHM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHHM_ECOLI epestfind swissprot:YHHM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHHM_ECOLI garnier swissprot:YHHM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHHM_ECOLI helixturnhelix swissprot:YHHM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHHM_ECOLI hmoment swissprot:YHHM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHHM_ECOLI iep swissprot:YHHM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHHM_ECOLI inforesidue swissprot:YHHM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHHM_ECOLI octanol swissprot:YHHM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHHM_ECOLI pepcoil swissprot:YHHM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHHM_ECOLI pepdigest swissprot:YHHM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHHM_ECOLI pepinfo swissprot:YHHM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHHM_ECOLI pepnet swissprot:YHHM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHHM_ECOLI pepstats swissprot:YHHM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHHM_ECOLI pepwheel swissprot:YHHM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHHM_ECOLI pepwindow swissprot:YHHM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHHM_ECOLI sigcleave swissprot:YHHM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHHM_ECOLI ## Database ID URL or Descriptions # AltName SYV_ECOLI Valyl-tRNA synthetase # BIOPHYSICOCHEMICAL PROPERTIES SYV_ECOLI Kinetic parameters KM=0.1 uM for tRNA {ECO 0000269|PubMed 12475234}; KM=47 uM for valine {ECO 0000269|PubMed 12475234}; # BioGrid 4262724 7 # CATALYTIC ACTIVITY SYV_ECOLI ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val). # CDD cd07962 Anticodon_Ia_Val # DOMAIN SYV_ECOLI The C-terminal coiled-coil domain is crucial for aminoacylation activity. {ECO 0000250}. # DOMAIN SYV_ECOLI ValRS has two distinct active sites one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site. # EcoGene EG11067 valS # FUNCTION SYV_ECOLI Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a "posttransfer" editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0002161 aminoacyl-tRNA editing activity; IDA:EcoCyc. # GO_function GO:0004832 valine-tRNA ligase activity; IMP:GO_Central. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006438 valyl-tRNA aminoacylation; IMP:EcoCyc. # GO_process GO:0045903 positive regulation of translational fidelity; IMP:EcoCyc. # GO_process GO:0061475 cytosolic valyl-tRNA aminoacylation; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0008150 biological_process # Gene3D 1.10.287.380 -; 1. # Gene3D 1.10.730.10 -; 1. # Gene3D 3.40.50.620 -; 3. # Gene3D 3.90.740.10 -; 1. # HAMAP MF_02004 Val_tRNA_synth_type1 # IntAct P07118 5 # InterPro IPR001412 aa-tRNA-synth_I_CS # InterPro IPR002300 aa-tRNA-synth_Ia # InterPro IPR002303 Valyl-tRNA_ligase # InterPro IPR009008 Val/Leu/Ile-tRNA-synth_edit # InterPro IPR009080 tRNAsynth_Ia_anticodon-bd # InterPro IPR010978 tRNA-bd_arm # InterPro IPR013155 M/V/L/I-tRNA-synth_anticd-bd # InterPro IPR014729 Rossmann-like_a/b/a_fold # InterPro IPR019499 Val-tRNA_synth_tRNA-bd # InterPro IPR033705 Anticodon_Ia_Val # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01007 Amino acid related enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # KEGG_Pathway ko00970 Aminoacyl-tRNA biosynthesis # Organism SYV_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11946:SF5 PTHR11946:SF5; 3 # PATRIC 32124087 VBIEscCol129921_4388 # PIR E65238 SYECVT # PRINTS PR00986 TRNASYNTHVAL # PROSITE PS00178 AA_TRNA_LIGASE_I # Pfam PF00133 tRNA-synt_1 # Pfam PF08264 Anticodon_1 # Pfam PF10458 Val_tRNA-synt_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SYV_ECOLI Valine--tRNA ligase # RefSeq NP_418679 NC_000913.3 # RefSeq WP_000416392 NZ_LN832404.1 # SIMILARITY Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION SYV_ECOLI Cytoplasm. # SUBUNIT SYV_ECOLI Monomer. # SUPFAM SSF46589 SSF46589 # SUPFAM SSF47323 SSF47323 # SUPFAM SSF50677 SSF50677 # TIGRFAMs TIGR00422 valS # eggNOG COG0525 LUCA # eggNOG ENOG4105CA4 Bacteria BLAST swissprot:SYV_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SYV_ECOLI BioCyc ECOL316407:JW4215-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4215-MONOMER BioCyc EcoCyc:VALS-MONOMER http://biocyc.org/getid?id=EcoCyc:VALS-MONOMER BioCyc MetaCyc:VALS-MONOMER http://biocyc.org/getid?id=MetaCyc:VALS-MONOMER COG COG0525 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0525 DIP DIP-11112N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11112N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1021/bi0205101 http://dx.doi.org/10.1021/bi0205101 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/15.21.9081 http://dx.doi.org/10.1093/nar/15.21.9081 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.1057718 http://dx.doi.org/10.1126/science.1057718 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.1.1.9 http://www.genome.jp/dbget-bin/www_bget?EC:6.1.1.9 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL AY283771 http://www.ebi.ac.uk/ena/data/view/AY283771 EMBL J03497 http://www.ebi.ac.uk/ena/data/view/J03497 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X05891 http://www.ebi.ac.uk/ena/data/view/X05891 ENZYME 6.1.1.9 http://enzyme.expasy.org/EC/6.1.1.9 EchoBASE EB1060 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1060 EcoGene EG11067 http://www.ecogene.org/geneInfo.php?eg_id=EG11067 EnsemblBacteria AAC77215 http://www.ensemblgenomes.org/id/AAC77215 EnsemblBacteria AAC77215 http://www.ensemblgenomes.org/id/AAC77215 EnsemblBacteria BAE78255 http://www.ensemblgenomes.org/id/BAE78255 EnsemblBacteria BAE78255 http://www.ensemblgenomes.org/id/BAE78255 EnsemblBacteria BAE78255 http://www.ensemblgenomes.org/id/BAE78255 EnsemblBacteria b4258 http://www.ensemblgenomes.org/id/b4258 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0002161 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002161 GO_function GO:0004832 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004832 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006438 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006438 GO_process GO:0045903 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045903 GO_process GO:0061475 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061475 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.10.287.380 http://www.cathdb.info/version/latest/superfamily/1.10.287.380 Gene3D 1.10.730.10 http://www.cathdb.info/version/latest/superfamily/1.10.730.10 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 Gene3D 3.90.740.10 http://www.cathdb.info/version/latest/superfamily/3.90.740.10 GeneID 948785 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948785 HAMAP MF_02004 http://hamap.expasy.org/unirule/MF_02004 HOGENOM HOG000020094 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000020094&db=HOGENOM6 InParanoid P07118 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P07118 IntAct P07118 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P07118* IntEnz 6.1.1.9 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.1.1.9 InterPro IPR001412 http://www.ebi.ac.uk/interpro/entry/IPR001412 InterPro IPR002300 http://www.ebi.ac.uk/interpro/entry/IPR002300 InterPro IPR002303 http://www.ebi.ac.uk/interpro/entry/IPR002303 InterPro IPR009008 http://www.ebi.ac.uk/interpro/entry/IPR009008 InterPro IPR009080 http://www.ebi.ac.uk/interpro/entry/IPR009080 InterPro IPR010978 http://www.ebi.ac.uk/interpro/entry/IPR010978 InterPro IPR013155 http://www.ebi.ac.uk/interpro/entry/IPR013155 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 InterPro IPR019499 http://www.ebi.ac.uk/interpro/entry/IPR019499 InterPro IPR033705 http://www.ebi.ac.uk/interpro/entry/IPR033705 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW4215 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4215 KEGG_Gene eco:b4258 http://www.genome.jp/dbget-bin/www_bget?eco:b4258 KEGG_Orthology KO:K01873 http://www.genome.jp/dbget-bin/www_bget?KO:K01873 KEGG_Pathway ko00970 http://www.genome.jp/kegg-bin/show_pathway?ko00970 KEGG_Reaction rn:R03665 http://www.genome.jp/dbget-bin/www_bget?rn:R03665 MINT MINT-1260839 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1260839 OMA SQYRFDL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SQYRFDL PANTHER PTHR11946:SF5 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11946:SF5 PRINTS PR00986 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00986 PROSITE PS00178 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00178 PSORT swissprot:SYV_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SYV_ECOLI PSORT-B swissprot:SYV_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SYV_ECOLI PSORT2 swissprot:SYV_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SYV_ECOLI Pfam PF00133 http://pfam.xfam.org/family/PF00133 Pfam PF08264 http://pfam.xfam.org/family/PF08264 Pfam PF10458 http://pfam.xfam.org/family/PF10458 Phobius swissprot:SYV_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SYV_ECOLI PhylomeDB P07118 http://phylomedb.org/?seqid=P07118 ProteinModelPortal P07118 http://www.proteinmodelportal.org/query/uniprot/P07118 PubMed 11313495 http://www.ncbi.nlm.nih.gov/pubmed/11313495 PubMed 12475234 http://www.ncbi.nlm.nih.gov/pubmed/12475234 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3275660 http://www.ncbi.nlm.nih.gov/pubmed/3275660 PubMed 3317277 http://www.ncbi.nlm.nih.gov/pubmed/3317277 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_418679 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418679 RefSeq WP_000416392 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000416392 STRING 511145.b4258 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4258&targetmode=cogs STRING COG0525 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0525&targetmode=cogs SUPFAM SSF46589 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46589 SUPFAM SSF47323 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47323 SUPFAM SSF50677 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50677 TIGRFAMs TIGR00422 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00422 UniProtKB SYV_ECOLI http://www.uniprot.org/uniprot/SYV_ECOLI UniProtKB-AC P07118 http://www.uniprot.org/uniprot/P07118 charge swissprot:SYV_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SYV_ECOLI eggNOG COG0525 http://eggnogapi.embl.de/nog_data/html/tree/COG0525 eggNOG ENOG4105CA4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CA4 epestfind swissprot:SYV_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SYV_ECOLI garnier swissprot:SYV_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SYV_ECOLI helixturnhelix swissprot:SYV_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SYV_ECOLI hmoment swissprot:SYV_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SYV_ECOLI iep swissprot:SYV_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SYV_ECOLI inforesidue swissprot:SYV_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SYV_ECOLI octanol swissprot:SYV_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SYV_ECOLI pepcoil swissprot:SYV_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SYV_ECOLI pepdigest swissprot:SYV_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SYV_ECOLI pepinfo swissprot:SYV_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SYV_ECOLI pepnet swissprot:SYV_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SYV_ECOLI pepstats swissprot:SYV_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SYV_ECOLI pepwheel swissprot:SYV_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SYV_ECOLI pepwindow swissprot:SYV_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SYV_ECOLI sigcleave swissprot:SYV_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SYV_ECOLI ## Database ID URL or Descriptions # BioGrid 4260834 3 # EcoGene EG12024 yohK # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR005261 CHP00659 # InterPro IPR007300 CidB/LrgB # Organism YOHK_ECOLI Escherichia coli (strain K12) # PATRIC 32119627 VBIEscCol129921_2224 # PIR E64982 E64982 # Pfam PF04172 LrgB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YOHK_ECOLI Inner membrane protein YohK # RefSeq NP_416647 NC_000913.3 # RefSeq WP_000968208 NZ_LN832404.1 # SIMILARITY Belongs to the YohK (E.coli)/YwbG (IPA-22R) (B.subtilis) family. {ECO 0000305}. # SUBCELLULAR LOCATION YOHK_ECOLI Cell inner membrane; Multi-pass membrane protein. # TIGRFAMs TIGR00659 TIGR00659 # eggNOG COG1346 LUCA # eggNOG ENOG41067MG Bacteria BLAST swissprot:YOHK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YOHK_ECOLI BioCyc ECOL316407:JW2130-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2130-MONOMER BioCyc EcoCyc:EG12024-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12024-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1989.tb00120.x http://dx.doi.org/10.1111/j.1365-2958.1989.tb00120.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X16419 http://www.ebi.ac.uk/ena/data/view/X16419 EchoBASE EB1959 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1959 EcoGene EG12024 http://www.ecogene.org/geneInfo.php?eg_id=EG12024 EnsemblBacteria AAC75203 http://www.ensemblgenomes.org/id/AAC75203 EnsemblBacteria AAC75203 http://www.ensemblgenomes.org/id/AAC75203 EnsemblBacteria BAE76619 http://www.ensemblgenomes.org/id/BAE76619 EnsemblBacteria BAE76619 http://www.ensemblgenomes.org/id/BAE76619 EnsemblBacteria BAE76619 http://www.ensemblgenomes.org/id/BAE76619 EnsemblBacteria b2142 http://www.ensemblgenomes.org/id/b2142 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 949125 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949125 HOGENOM HOG000253604 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000253604&db=HOGENOM6 InParanoid P0AD19 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AD19 InterPro IPR005261 http://www.ebi.ac.uk/interpro/entry/IPR005261 InterPro IPR007300 http://www.ebi.ac.uk/interpro/entry/IPR007300 KEGG_Gene ecj:JW2130 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2130 KEGG_Gene eco:b2142 http://www.genome.jp/dbget-bin/www_bget?eco:b2142 OMA WVYLSAS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WVYLSAS PSORT swissprot:YOHK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YOHK_ECOLI PSORT-B swissprot:YOHK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YOHK_ECOLI PSORT2 swissprot:YOHK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YOHK_ECOLI Pfam PF04172 http://pfam.xfam.org/family/PF04172 Phobius swissprot:YOHK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YOHK_ECOLI PhylomeDB P0AD19 http://phylomedb.org/?seqid=P0AD19 ProteinModelPortal P0AD19 http://www.proteinmodelportal.org/query/uniprot/P0AD19 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2575702 http://www.ncbi.nlm.nih.gov/pubmed/2575702 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416647 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416647 RefSeq WP_000968208 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000968208 STRING 511145.b2142 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2142&targetmode=cogs TIGRFAMs TIGR00659 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00659 UniProtKB YOHK_ECOLI http://www.uniprot.org/uniprot/YOHK_ECOLI UniProtKB-AC P0AD19 http://www.uniprot.org/uniprot/P0AD19 charge swissprot:YOHK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YOHK_ECOLI eggNOG COG1346 http://eggnogapi.embl.de/nog_data/html/tree/COG1346 eggNOG ENOG41067MG http://eggnogapi.embl.de/nog_data/html/tree/ENOG41067MG epestfind swissprot:YOHK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YOHK_ECOLI garnier swissprot:YOHK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YOHK_ECOLI helixturnhelix swissprot:YOHK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YOHK_ECOLI hmoment swissprot:YOHK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YOHK_ECOLI iep swissprot:YOHK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YOHK_ECOLI inforesidue swissprot:YOHK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YOHK_ECOLI octanol swissprot:YOHK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YOHK_ECOLI pepcoil swissprot:YOHK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YOHK_ECOLI pepdigest swissprot:YOHK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YOHK_ECOLI pepinfo swissprot:YOHK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YOHK_ECOLI pepnet swissprot:YOHK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YOHK_ECOLI pepstats swissprot:YOHK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YOHK_ECOLI pepwheel swissprot:YOHK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YOHK_ECOLI pepwindow swissprot:YOHK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YOHK_ECOLI sigcleave swissprot:YOHK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YOHK_ECOLI ## Database ID URL or Descriptions # AltName TUSB_ECOLI tRNA 2-thiouridine synthesizing protein B # BioGrid 4261617 51 # EcoGene EG12896 tusB # FUNCTION TUSB_ECOLI Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. {ECO 0000269|PubMed 16387657}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_process GO:0002143 tRNA wobble position uridine thiolation; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_process GO:0006399 tRNA metabolic process # Gene3D 3.40.1260.10 -; 1. # HAMAP MF_01564 Thiourid_synth_B # IntAct P45530 3 # InterPro IPR007215 Sulphur_relay_TusB/DsrH # InterPro IPR023526 Sulphur_relay_TusB # InterPro IPR027396 DsrEFH-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko03016 Transfer RNA biogenesis # KEGG_Pathway ko04122 Sulfur relay system # Organism TUSB_ECOLI Escherichia coli (strain K12) # PATRIC 32122118 VBIEscCol129921_3436 # PDB 2D1P X-ray; 2.15 A; C/F/I=1-95 # PIR B65128 B65128 # Pfam PF04077 DsrH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TUSB_ECOLI Protein TusB # RefSeq NP_417802 NC_000913.3 # RefSeq WP_000903373 NZ_LN832404.1 # SIMILARITY Belongs to the DsrH/TusB family. {ECO 0000305}. # SUBCELLULAR LOCATION TUSB_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT TUSB_ECOLI Heterohexamer, formed by a dimer of trimers. The hexameric TusBCD complex contains 2 copies each of TusB, TusC and TusD. The TusBCD complex interacts with TusE. {ECO 0000269|PubMed 16387657, ECO 0000269|PubMed 16472754}. # SUPFAM SSF75169 SSF75169 # TIGRFAMs TIGR03011 sulf_tusB_dsrH # eggNOG COG2168 LUCA # eggNOG ENOG4105YKK Bacteria BLAST swissprot:TUSB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TUSB_ECOLI BioCyc ECOL316407:JW3305-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3305-MONOMER BioCyc EcoCyc:G7712-MONOMER http://biocyc.org/getid?id=EcoCyc:G7712-MONOMER BioCyc MetaCyc:G7712-MONOMER http://biocyc.org/getid?id=MetaCyc:G7712-MONOMER COG COG2168 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2168 DIP DIP-12308N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12308N DOI 10.1016/j.molcel.2005.11.001 http://dx.doi.org/10.1016/j.molcel.2005.11.001 DOI 10.1016/j.str.2005.11.009 http://dx.doi.org/10.1016/j.str.2005.11.009 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2733 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2733 EcoGene EG12896 http://www.ecogene.org/geneInfo.php?eg_id=EG12896 EnsemblBacteria AAC76368 http://www.ensemblgenomes.org/id/AAC76368 EnsemblBacteria AAC76368 http://www.ensemblgenomes.org/id/AAC76368 EnsemblBacteria BAE77948 http://www.ensemblgenomes.org/id/BAE77948 EnsemblBacteria BAE77948 http://www.ensemblgenomes.org/id/BAE77948 EnsemblBacteria BAE77948 http://www.ensemblgenomes.org/id/BAE77948 EnsemblBacteria b3343 http://www.ensemblgenomes.org/id/b3343 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_process GO:0002143 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002143 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 Gene3D 3.40.1260.10 http://www.cathdb.info/version/latest/superfamily/3.40.1260.10 GeneID 947844 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947844 HAMAP MF_01564 http://hamap.expasy.org/unirule/MF_01564 HOGENOM HOG000284333 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000284333&db=HOGENOM6 InParanoid P45530 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45530 IntAct P45530 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45530* InterPro IPR007215 http://www.ebi.ac.uk/interpro/entry/IPR007215 InterPro IPR023526 http://www.ebi.ac.uk/interpro/entry/IPR023526 InterPro IPR027396 http://www.ebi.ac.uk/interpro/entry/IPR027396 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW3305 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3305 KEGG_Gene eco:b3343 http://www.genome.jp/dbget-bin/www_bget?eco:b3343 KEGG_Orthology KO:K07237 http://www.genome.jp/dbget-bin/www_bget?KO:K07237 KEGG_Pathway ko04122 http://www.genome.jp/kegg-bin/show_pathway?ko04122 OMA HASQMAW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HASQMAW PDB 2D1P http://www.ebi.ac.uk/pdbe-srv/view/entry/2D1P PDBsum 2D1P http://www.ebi.ac.uk/pdbsum/2D1P PSORT swissprot:TUSB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TUSB_ECOLI PSORT-B swissprot:TUSB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TUSB_ECOLI PSORT2 swissprot:TUSB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TUSB_ECOLI Pfam PF04077 http://pfam.xfam.org/family/PF04077 Phobius swissprot:TUSB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TUSB_ECOLI ProteinModelPortal P45530 http://www.proteinmodelportal.org/query/uniprot/P45530 PubMed 16387657 http://www.ncbi.nlm.nih.gov/pubmed/16387657 PubMed 16472754 http://www.ncbi.nlm.nih.gov/pubmed/16472754 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417802 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417802 RefSeq WP_000903373 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000903373 SMR P45530 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45530 STRING 511145.b3343 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3343&targetmode=cogs STRING COG2168 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2168&targetmode=cogs SUPFAM SSF75169 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF75169 TIGRFAMs TIGR03011 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03011 UniProtKB TUSB_ECOLI http://www.uniprot.org/uniprot/TUSB_ECOLI UniProtKB-AC P45530 http://www.uniprot.org/uniprot/P45530 charge swissprot:TUSB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TUSB_ECOLI eggNOG COG2168 http://eggnogapi.embl.de/nog_data/html/tree/COG2168 eggNOG ENOG4105YKK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105YKK epestfind swissprot:TUSB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TUSB_ECOLI garnier swissprot:TUSB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TUSB_ECOLI helixturnhelix swissprot:TUSB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TUSB_ECOLI hmoment swissprot:TUSB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TUSB_ECOLI iep swissprot:TUSB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TUSB_ECOLI inforesidue swissprot:TUSB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TUSB_ECOLI octanol swissprot:TUSB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TUSB_ECOLI pepcoil swissprot:TUSB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TUSB_ECOLI pepdigest swissprot:TUSB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TUSB_ECOLI pepinfo swissprot:TUSB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TUSB_ECOLI pepnet swissprot:TUSB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TUSB_ECOLI pepstats swissprot:TUSB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TUSB_ECOLI pepwheel swissprot:TUSB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TUSB_ECOLI pepwindow swissprot:TUSB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TUSB_ECOLI sigcleave swissprot:TUSB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TUSB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260932 56 # DISRUPTION PHENOTYPE Cells lacking this gene are sensitive to oxidative stress and DNA damage at high temperature. They also exhibit filamentation. {ECO:0000269|PubMed 17766410}. # EcoGene EG11376 ftsP # FUNCTION FTSP_ECOLI Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress. {ECO 0000255|HAMAP-Rule MF_00915, ECO 0000269|PubMed 17766410}. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_component GO:0032153 cell division site; IEA:UniProtKB-HAMAP. # GO_function FTSP_ECOLI GO 0052716 hydroquinone oxygen oxidoreductase activity; IBA GO_Central. # GO_function GO:0005507 copper ion binding; IBA:GO_Central. # GO_function GO:0016722 oxidoreductase activity, oxidizing metal ions; IBA:GO_Central. # GO_process GO:0043093 FtsZ-dependent cytokinesis; IEA:UniProtKB-HAMAP. # GO_process GO:0051301 cell division; IMP:CACAO. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0051301 cell division # Gene3D 2.60.40.420 -; 3. # HAMAP MF_00915 FtsP # IntAct P26648 7 # InterPro IPR001117 Cu-oxidase # InterPro IPR006311 TAT_signal # InterPro IPR008972 Cupredoxin # InterPro IPR011706 Cu-oxidase_2 # InterPro IPR011707 Cu-oxidase_3 # InterPro IPR019546 TAT_signal_bac_arc # InterPro IPR026589 FtsP # MISCELLANEOUS FTSP_ECOLI Is used as a model substrate in studies of the twin-arginine translocation (Tat) protein transport system. # Organism FTSP_ECOLI Escherichia coli (strain K12) # PATRIC 32121448 VBIEscCol129921_3111 # PDB 2UXT X-ray; 1.90 A; A/B=28-470 # PDB 2UXV X-ray; 2.61 A; A/B=28-470 # PIR G65088 G65088 # PROSITE PS51318 TAT # PTM FTSP_ECOLI Exported by the Tat system. The position of the signal peptide cleavage has been experimentally proven. Can also be exported by the Sec system. # Pfam PF00394 Cu-oxidase # Pfam PF07731 Cu-oxidase_2 # Pfam PF07732 Cu-oxidase_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Cell division protein FtsP {ECO:0000255|HAMAP-Rule MF_00915} # RefSeq NP_417489 NC_000913.3 # RefSeq WP_000059388 NZ_LN832404.1 # SIMILARITY Belongs to the FtsP family. {ECO:0000255|HAMAP- Rule MF_00915}. # SIMILARITY Contains 1 plastocyanin-like domain. {ECO:0000255|HAMAP-Rule MF_00915}. # SUBCELLULAR LOCATION FTSP_ECOLI Periplasm {ECO 0000255|HAMAP-Rule MF_00915, ECO 0000269|PubMed 10593889, ECO 0000269|PubMed 19135451}. Note=Localizes to the division septum. Localization requires FtsZ, FtsQ, FtsL and FtsN. # SUPFAM SSF49503 SSF49503; 3 # TIGRFAMs TIGR01409 TAT_signal_seq # eggNOG COG2132 LUCA # eggNOG ENOG4107TZ2 Bacteria BLAST swissprot:FTSP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FTSP_ECOLI BioCyc ECOL316407:JW2985-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2985-MONOMER BioCyc EcoCyc:EG11376-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11376-MONOMER COG COG2132 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2132 DIP DIP-10942N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10942N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1016/j.jmb.2008.12.043 http://dx.doi.org/10.1016/j.jmb.2008.12.043 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.274.51.36073 http://dx.doi.org/10.1074/jbc.274.51.36073 DOI 10.1074/jbc.M610507200 http://dx.doi.org/10.1074/jbc.M610507200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00773-07 http://dx.doi.org/10.1128/JB.00773-07 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M63491 http://www.ebi.ac.uk/ena/data/view/M63491 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB1350 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1350 EcoGene EG11376 http://www.ecogene.org/geneInfo.php?eg_id=EG11376 EnsemblBacteria AAC76053 http://www.ensemblgenomes.org/id/AAC76053 EnsemblBacteria AAC76053 http://www.ensemblgenomes.org/id/AAC76053 EnsemblBacteria BAE77073 http://www.ensemblgenomes.org/id/BAE77073 EnsemblBacteria BAE77073 http://www.ensemblgenomes.org/id/BAE77073 EnsemblBacteria BAE77073 http://www.ensemblgenomes.org/id/BAE77073 EnsemblBacteria b3017 http://www.ensemblgenomes.org/id/b3017 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_component GO:0032153 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032153 GO_function GO:0005507 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005507 GO_function GO:0016722 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016722 GO_function GO:0052716 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052716 GO_process GO:0043093 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043093 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 Gene3D 2.60.40.420 http://www.cathdb.info/version/latest/superfamily/2.60.40.420 GeneID 944982 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944982 HAMAP MF_00915 http://hamap.expasy.org/unirule/MF_00915 HOGENOM HOG000096435 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000096435&db=HOGENOM6 InParanoid P26648 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P26648 IntAct P26648 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P26648* InterPro IPR001117 http://www.ebi.ac.uk/interpro/entry/IPR001117 InterPro IPR006311 http://www.ebi.ac.uk/interpro/entry/IPR006311 InterPro IPR008972 http://www.ebi.ac.uk/interpro/entry/IPR008972 InterPro IPR011706 http://www.ebi.ac.uk/interpro/entry/IPR011706 InterPro IPR011707 http://www.ebi.ac.uk/interpro/entry/IPR011707 InterPro IPR019546 http://www.ebi.ac.uk/interpro/entry/IPR019546 InterPro IPR026589 http://www.ebi.ac.uk/interpro/entry/IPR026589 KEGG_Gene ecj:JW2985 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2985 KEGG_Gene eco:b3017 http://www.genome.jp/dbget-bin/www_bget?eco:b3017 KEGG_Orthology KO:K04753 http://www.genome.jp/dbget-bin/www_bget?KO:K04753 OMA PSYEHFP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PSYEHFP PDB 2UXT http://www.ebi.ac.uk/pdbe-srv/view/entry/2UXT PDB 2UXV http://www.ebi.ac.uk/pdbe-srv/view/entry/2UXV PDBsum 2UXT http://www.ebi.ac.uk/pdbsum/2UXT PDBsum 2UXV http://www.ebi.ac.uk/pdbsum/2UXV PROSITE PS51318 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51318 PSORT swissprot:FTSP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FTSP_ECOLI PSORT-B swissprot:FTSP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FTSP_ECOLI PSORT2 swissprot:FTSP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FTSP_ECOLI Pfam PF00394 http://pfam.xfam.org/family/PF00394 Pfam PF07731 http://pfam.xfam.org/family/PF07731 Pfam PF07732 http://pfam.xfam.org/family/PF07732 Phobius swissprot:FTSP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FTSP_ECOLI PhylomeDB P26648 http://phylomedb.org/?seqid=P26648 ProteinModelPortal P26648 http://www.proteinmodelportal.org/query/uniprot/P26648 PubMed 10593889 http://www.ncbi.nlm.nih.gov/pubmed/10593889 PubMed 1557036 http://www.ncbi.nlm.nih.gov/pubmed/1557036 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17218314 http://www.ncbi.nlm.nih.gov/pubmed/17218314 PubMed 17766410 http://www.ncbi.nlm.nih.gov/pubmed/17766410 PubMed 19135451 http://www.ncbi.nlm.nih.gov/pubmed/19135451 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_417489 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417489 RefSeq WP_000059388 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000059388 SMR P26648 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P26648 STRING 511145.b3017 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3017&targetmode=cogs STRING COG2132 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2132&targetmode=cogs SUPFAM SSF49503 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49503 TIGRFAMs TIGR01409 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01409 UniProtKB FTSP_ECOLI http://www.uniprot.org/uniprot/FTSP_ECOLI UniProtKB-AC P26648 http://www.uniprot.org/uniprot/P26648 charge swissprot:FTSP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FTSP_ECOLI eggNOG COG2132 http://eggnogapi.embl.de/nog_data/html/tree/COG2132 eggNOG ENOG4107TZ2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107TZ2 epestfind swissprot:FTSP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FTSP_ECOLI garnier swissprot:FTSP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FTSP_ECOLI helixturnhelix swissprot:FTSP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FTSP_ECOLI hmoment swissprot:FTSP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FTSP_ECOLI iep swissprot:FTSP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FTSP_ECOLI inforesidue swissprot:FTSP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FTSP_ECOLI octanol swissprot:FTSP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FTSP_ECOLI pepcoil swissprot:FTSP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FTSP_ECOLI pepdigest swissprot:FTSP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FTSP_ECOLI pepinfo swissprot:FTSP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FTSP_ECOLI pepnet swissprot:FTSP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FTSP_ECOLI pepstats swissprot:FTSP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FTSP_ECOLI pepwheel swissprot:FTSP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FTSP_ECOLI pepwindow swissprot:FTSP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FTSP_ECOLI sigcleave swissprot:FTSP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FTSP_ECOLI ## Database ID URL or Descriptions # BioGrid 4261452 162 # EcoGene EG11706 yidK # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0015293 symporter activity; IBA:GO_Central. # GO_process GO:0006814 sodium ion transport; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # IntAct P31448 5 # InterPro IPR001734 Na/solute_symporter # InterPro IPR018212 Na/solute_symporter_CS # Organism YIDK_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11819 PTHR11819; 2 # PATRIC 32122849 VBIEscCol129921_3800 # PIR H65169 H65169 # PROSITE PS00456 NA_SOLUT_SYMP_1 # PROSITE PS50283 NA_SOLUT_SYMP_3 # Pfam PF00474 SSF # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIDK_ECOLI Uncharacterized symporter YidK # RefSeq NP_418135 NC_000913.3 # RefSeq WP_001087145 NZ_LN832404.1 # SIMILARITY Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. {ECO 0000305}. # SUBCELLULAR LOCATION YIDK_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.21.3.21:the solute sodium symporter (sss) family # TIGRFAMs TIGR00813 sss # eggNOG COG4146 LUCA # eggNOG ENOG4107RUZ Bacteria BLAST swissprot:YIDK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIDK_ECOLI BioCyc ECOL316407:JW3655-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3655-MONOMER BioCyc EcoCyc:YIDK-MONOMER http://biocyc.org/getid?id=EcoCyc:YIDK-MONOMER COG COG0591 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0591 COG COG4146 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4146 DIP DIP-12450N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12450N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1657 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1657 EcoGene EG11706 http://www.ecogene.org/geneInfo.php?eg_id=EG11706 EnsemblBacteria AAC76702 http://www.ensemblgenomes.org/id/AAC76702 EnsemblBacteria AAC76702 http://www.ensemblgenomes.org/id/AAC76702 EnsemblBacteria BAE77614 http://www.ensemblgenomes.org/id/BAE77614 EnsemblBacteria BAE77614 http://www.ensemblgenomes.org/id/BAE77614 EnsemblBacteria BAE77614 http://www.ensemblgenomes.org/id/BAE77614 EnsemblBacteria b3679 http://www.ensemblgenomes.org/id/b3679 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015293 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293 GO_process GO:0006814 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948185 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948185 HOGENOM HOG000025424 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000025424&db=HOGENOM6 InParanoid P31448 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31448 IntAct P31448 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31448* InterPro IPR001734 http://www.ebi.ac.uk/interpro/entry/IPR001734 InterPro IPR018212 http://www.ebi.ac.uk/interpro/entry/IPR018212 KEGG_Gene ecj:JW3655 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3655 KEGG_Gene eco:b3679 http://www.genome.jp/dbget-bin/www_bget?eco:b3679 KEGG_Orthology KO:K03307 http://www.genome.jp/dbget-bin/www_bget?KO:K03307 MINT MINT-1256907 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1256907 OMA LAQFGGY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LAQFGGY PANTHER PTHR11819 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11819 PROSITE PS00456 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00456 PROSITE PS50283 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50283 PSORT swissprot:YIDK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIDK_ECOLI PSORT-B swissprot:YIDK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIDK_ECOLI PSORT2 swissprot:YIDK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIDK_ECOLI Pfam PF00474 http://pfam.xfam.org/family/PF00474 Phobius swissprot:YIDK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIDK_ECOLI PhylomeDB P31448 http://phylomedb.org/?seqid=P31448 ProteinModelPortal P31448 http://www.proteinmodelportal.org/query/uniprot/P31448 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418135 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418135 RefSeq WP_001087145 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001087145 STRING 511145.b3679 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3679&targetmode=cogs STRING COG0591 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0591&targetmode=cogs STRING COG4146 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4146&targetmode=cogs TCDB 2.A.21.3.21 http://www.tcdb.org/search/result.php?tc=2.A.21.3.21 TIGRFAMs TIGR00813 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00813 UniProtKB YIDK_ECOLI http://www.uniprot.org/uniprot/YIDK_ECOLI UniProtKB-AC P31448 http://www.uniprot.org/uniprot/P31448 charge swissprot:YIDK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIDK_ECOLI eggNOG COG4146 http://eggnogapi.embl.de/nog_data/html/tree/COG4146 eggNOG ENOG4107RUZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107RUZ epestfind swissprot:YIDK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIDK_ECOLI garnier swissprot:YIDK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIDK_ECOLI helixturnhelix swissprot:YIDK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIDK_ECOLI hmoment swissprot:YIDK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIDK_ECOLI iep swissprot:YIDK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIDK_ECOLI inforesidue swissprot:YIDK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIDK_ECOLI octanol swissprot:YIDK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIDK_ECOLI pepcoil swissprot:YIDK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIDK_ECOLI pepdigest swissprot:YIDK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIDK_ECOLI pepinfo swissprot:YIDK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIDK_ECOLI pepnet swissprot:YIDK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIDK_ECOLI pepstats swissprot:YIDK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIDK_ECOLI pepwheel swissprot:YIDK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIDK_ECOLI pepwindow swissprot:YIDK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIDK_ECOLI sigcleave swissprot:YIDK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIDK_ECOLI ## Database ID URL or Descriptions # AltName RPIB_ECOLI Phosphoriboisomerase B # BIOPHYSICOCHEMICAL PROPERTIES RPIB_ECOLI Kinetic parameters KM=0.83 mM for D-ribose 5-phosphate (at 37 degrees Celsius) {ECO 0000269|PubMed 1104357}; KM=1.23 mM for D-ribose 5-phosphate {ECO 0000269|PubMed 18640127}; KM=0.5 mM for D-allose 6-phosphate {ECO 0000269|PubMed 18640127}; Temperature dependence After incubation at 45 degrees Celsius for 30 minutes RpiB retains 65% of its original activities. At 60 degrees Celsius RpiB is rapidly inactivated. {ECO 0000269|PubMed 1104357, ECO 0000269|PubMed 14499611, ECO 0000269|PubMed 18640127}; # BioGrid 4262683 7 # CATALYTIC ACTIVITY RPIB_ECOLI D-allose 6-phosphate = D-allulose 6-phosphate. # CATALYTIC ACTIVITY RPIB_ECOLI D-ribose 5-phosphate = D-ribulose 5-phosphate. # ENZYME REGULATION RPIB_ECOLI Inhibited by iodoacetate and glucose 6- phosphate. {ECO 0000269|PubMed 1104357, ECO 0000269|PubMed 4909663}. # EcoGene EG11827 rpiB # FUNCTION RPIB_ECOLI In addition to its activity on D-ribose 5-phosphate it probably also has activity on D-allose 6-phosphate. {ECO 0000269|PubMed 1104357, ECO 0000269|PubMed 18640127, ECO 0000269|PubMed 4909663, ECO 0000269|PubMed 8576032}. # GO_function GO:0004751 ribose-5-phosphate isomerase activity; IDA:EcoCyc. # GO_function GO:0008786 allose 6-phosphate isomerase activity; IDA:EcoCyc. # GO_process GO:0006098 pentose-phosphate shunt; IEA:UniProtKB-UniPathway. # GO_process GO:0019316 D-allose catabolic process; IMP:EcoCyc. # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.1400.10 -; 1. # INDUCTION RPIB_ECOLI Induced by ribose and repressed by RpiR. {ECO 0000269|PubMed 1104357, ECO 0000269|PubMed 8576032}. # IntAct P37351 3 # InterPro IPR003500 RpiB_LacA_LacB # InterPro IPR004785 RpiB # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00030 Pentose phosphate pathway # KEGG_Pathway ko00710 Carbon fixation in photosynthetic organisms # Organism RPIB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30345 PTHR30345 # PATHWAY Carbohydrate degradation; pentose phosphate pathway; D- ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage) step 1/1. # PATRIC 32123739 VBIEscCol129921_4218 # PDB 1NN4 X-ray; 2.20 A; A/B/C/D=1-149 # PDB 2VVR X-ray; 2.10 A; A/B/C/D/E/F=1-149 # PIR JC6054 JC6054 # PIRSF PIRSF005384 RpiB_LacA_B # Pfam PF02502 LacAB_rpiB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RPIB_ECOLI Ribose-5-phosphate isomerase B # RefSeq NP_418514 NC_000913.3 # RefSeq WP_000716794 NZ_LN832404.1 # SIMILARITY Belongs to the LacAB/RpiB family. {ECO 0000305}. # SUBUNIT Homodimer, and homotetramer. {ECO:0000269|PubMed 14499611}. # SUPFAM SSF89623 SSF89623 # TIGRFAMs TIGR00689 rpiB_lacA_lacB # TIGRFAMs TIGR01120 rpiB # UniPathway UPA00115 UER00412 # eggNOG COG0698 LUCA # eggNOG ENOG4108YZG Bacteria BLAST swissprot:RPIB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RPIB_ECOLI BioCyc ECOL316407:JW4051-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4051-MONOMER BioCyc EcoCyc:RIB5PISOMB-MONOMER http://biocyc.org/getid?id=EcoCyc:RIB5PISOMB-MONOMER BioCyc MetaCyc:RIB5PISOMB-MONOMER http://biocyc.org/getid?id=MetaCyc:RIB5PISOMB-MONOMER COG COG0698 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0698 DIP DIP-10740N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10740N DOI 10.1016/j.jmb.2003.08.009 http://dx.doi.org/10.1016/j.jmb.2003.08.009 DOI 10.1016/j.jmb.2008.06.090 http://dx.doi.org/10.1016/j.jmb.2008.06.090 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1111/j.1432-1033.1975.tb02166.x http://dx.doi.org/10.1111/j.1432-1033.1975.tb02166.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.3.1.6 http://www.genome.jp/dbget-bin/www_bget?EC:5.3.1.6 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D90227 http://www.ebi.ac.uk/ena/data/view/D90227 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X82203 http://www.ebi.ac.uk/ena/data/view/X82203 ENZYME 5.3.1.6 http://enzyme.expasy.org/EC/5.3.1.6 EchoBASE EB1774 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1774 EcoGene EG11827 http://www.ecogene.org/geneInfo.php?eg_id=EG11827 EnsemblBacteria AAC77051 http://www.ensemblgenomes.org/id/AAC77051 EnsemblBacteria AAC77051 http://www.ensemblgenomes.org/id/AAC77051 EnsemblBacteria BAE78093 http://www.ensemblgenomes.org/id/BAE78093 EnsemblBacteria BAE78093 http://www.ensemblgenomes.org/id/BAE78093 EnsemblBacteria BAE78093 http://www.ensemblgenomes.org/id/BAE78093 EnsemblBacteria b4090 http://www.ensemblgenomes.org/id/b4090 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004751 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004751 GO_function GO:0008786 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008786 GO_process GO:0006098 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006098 GO_process GO:0019316 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019316 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.1400.10 http://www.cathdb.info/version/latest/superfamily/3.40.1400.10 GeneID 948602 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948602 HOGENOM HOG000226301 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000226301&db=HOGENOM6 InParanoid P37351 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37351 IntAct P37351 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37351* IntEnz 5.3.1.6 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.3.1.6 InterPro IPR003500 http://www.ebi.ac.uk/interpro/entry/IPR003500 InterPro IPR004785 http://www.ebi.ac.uk/interpro/entry/IPR004785 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4051 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4051 KEGG_Gene eco:b4090 http://www.genome.jp/dbget-bin/www_bget?eco:b4090 KEGG_Orthology KO:K01808 http://www.genome.jp/dbget-bin/www_bget?KO:K01808 KEGG_Pathway ko00030 http://www.genome.jp/kegg-bin/show_pathway?ko00030 KEGG_Pathway ko00710 http://www.genome.jp/kegg-bin/show_pathway?ko00710 KEGG_Reaction rn:R01056 http://www.genome.jp/dbget-bin/www_bget?rn:R01056 MINT MINT-1235144 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1235144 OMA NDHAGTD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NDHAGTD PANTHER PTHR30345 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30345 PDB 1NN4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1NN4 PDB 2VVR http://www.ebi.ac.uk/pdbe-srv/view/entry/2VVR PDBsum 1NN4 http://www.ebi.ac.uk/pdbsum/1NN4 PDBsum 2VVR http://www.ebi.ac.uk/pdbsum/2VVR PSORT swissprot:RPIB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RPIB_ECOLI PSORT-B swissprot:RPIB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RPIB_ECOLI PSORT2 swissprot:RPIB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RPIB_ECOLI Pfam PF02502 http://pfam.xfam.org/family/PF02502 Phobius swissprot:RPIB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RPIB_ECOLI PhylomeDB P37351 http://phylomedb.org/?seqid=P37351 ProteinModelPortal P37351 http://www.proteinmodelportal.org/query/uniprot/P37351 PubMed 1104357 http://www.ncbi.nlm.nih.gov/pubmed/1104357 PubMed 14499611 http://www.ncbi.nlm.nih.gov/pubmed/14499611 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1840580 http://www.ncbi.nlm.nih.gov/pubmed/1840580 PubMed 18640127 http://www.ncbi.nlm.nih.gov/pubmed/18640127 PubMed 4909663 http://www.ncbi.nlm.nih.gov/pubmed/4909663 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 8576032 http://www.ncbi.nlm.nih.gov/pubmed/8576032 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9401019 http://www.ncbi.nlm.nih.gov/pubmed/9401019 RefSeq NP_418514 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418514 RefSeq WP_000716794 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000716794 SMR P37351 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37351 STRING 511145.b4090 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4090&targetmode=cogs STRING COG0698 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0698&targetmode=cogs SUPFAM SSF89623 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF89623 TIGRFAMs TIGR00689 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00689 TIGRFAMs TIGR01120 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01120 UniProtKB RPIB_ECOLI http://www.uniprot.org/uniprot/RPIB_ECOLI UniProtKB-AC P37351 http://www.uniprot.org/uniprot/P37351 charge swissprot:RPIB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RPIB_ECOLI eggNOG COG0698 http://eggnogapi.embl.de/nog_data/html/tree/COG0698 eggNOG ENOG4108YZG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108YZG epestfind swissprot:RPIB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RPIB_ECOLI garnier swissprot:RPIB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RPIB_ECOLI helixturnhelix swissprot:RPIB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RPIB_ECOLI hmoment swissprot:RPIB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RPIB_ECOLI iep swissprot:RPIB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RPIB_ECOLI inforesidue swissprot:RPIB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RPIB_ECOLI octanol swissprot:RPIB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RPIB_ECOLI pepcoil swissprot:RPIB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RPIB_ECOLI pepdigest swissprot:RPIB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RPIB_ECOLI pepinfo swissprot:RPIB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RPIB_ECOLI pepnet swissprot:RPIB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RPIB_ECOLI pepstats swissprot:RPIB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RPIB_ECOLI pepwheel swissprot:RPIB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RPIB_ECOLI pepwindow swissprot:RPIB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RPIB_ECOLI sigcleave swissprot:RPIB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RPIB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260850 11 # COFACTOR YDEN_ECOLI Name=Ca(2+); Xref=ChEBI CHEBI 29108; Evidence={ECO 0000250}; Note=Binds 1 Ca(2+) ion per subunit. {ECO 0000250}; # EcoGene EG13796 ydeN # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0008484 sulfuric ester hydrolase activity; IEA:InterPro. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0008152 metabolic process; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # Gene3D 3.40.720.10 -; 1. # InterPro IPR000917 Sulfatase_N # InterPro IPR017849 Alkaline_Pase-like_a/b/a # InterPro IPR017850 Alkaline_phosphatase_core # InterPro IPR024607 Sulfatase_CS # KEGG_Brite ko01000 Enzymes # Organism YDEN_ECOLI Escherichia coli (strain K12) # PATRIC 32118290 VBIEscCol129921_1565 # PIR E64903 E64903 # PROSITE PS00149 SULFATASE_2 # PROSITE PS00523 SULFATASE_1 # PTM YDEN_ECOLI The conversion to 3-oxoalanine (also known as C- formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. {ECO 0000250}. # Pfam PF00884 Sulfatase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDEN_ECOLI Uncharacterized sulfatase YdeN # RefSeq NP_416015 NC_000913.3 # RefSeq WP_001295684 NZ_LN832404.1 # SIMILARITY Belongs to the sulfatase family. {ECO 0000305}. # SUPFAM SSF53649 SSF53649; 3 # eggNOG COG3119 LUCA # eggNOG ENOG4105ENH Bacteria BLAST swissprot:YDEN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDEN_ECOLI BioCyc ECOL316407:JW5243-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5243-MONOMER BioCyc EcoCyc:G6788-MONOMER http://biocyc.org/getid?id=EcoCyc:G6788-MONOMER COG COG3119 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3119 DIP DIP-11682N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11682N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.6.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.6.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.6.- http://enzyme.expasy.org/EC/3.1.6.- EchoBASE EB3557 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3557 EcoGene EG13796 http://www.ecogene.org/geneInfo.php?eg_id=EG13796 EnsemblBacteria AAC74571 http://www.ensemblgenomes.org/id/AAC74571 EnsemblBacteria AAC74571 http://www.ensemblgenomes.org/id/AAC74571 EnsemblBacteria BAA15169 http://www.ensemblgenomes.org/id/BAA15169 EnsemblBacteria BAA15169 http://www.ensemblgenomes.org/id/BAA15169 EnsemblBacteria BAA15169 http://www.ensemblgenomes.org/id/BAA15169 EnsemblBacteria b1498 http://www.ensemblgenomes.org/id/b1498 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0008484 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008484 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0008152 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008152 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.720.10 http://www.cathdb.info/version/latest/superfamily/3.40.720.10 GeneID 945957 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945957 HOGENOM HOG000135352 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000135352&db=HOGENOM6 InParanoid P77318 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77318 IntAct P77318 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77318* IntEnz 3.1.6 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.6 InterPro IPR000917 http://www.ebi.ac.uk/interpro/entry/IPR000917 InterPro IPR017849 http://www.ebi.ac.uk/interpro/entry/IPR017849 InterPro IPR017850 http://www.ebi.ac.uk/interpro/entry/IPR017850 InterPro IPR024607 http://www.ebi.ac.uk/interpro/entry/IPR024607 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5243 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5243 KEGG_Gene eco:b1498 http://www.genome.jp/dbget-bin/www_bget?eco:b1498 KEGG_Orthology KO:K01138 http://www.genome.jp/dbget-bin/www_bget?KO:K01138 OMA TPRFHPK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TPRFHPK PROSITE PS00149 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00149 PROSITE PS00523 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00523 PSORT swissprot:YDEN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDEN_ECOLI PSORT-B swissprot:YDEN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDEN_ECOLI PSORT2 swissprot:YDEN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDEN_ECOLI Pfam PF00884 http://pfam.xfam.org/family/PF00884 Phobius swissprot:YDEN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDEN_ECOLI PhylomeDB P77318 http://phylomedb.org/?seqid=P77318 ProteinModelPortal P77318 http://www.proteinmodelportal.org/query/uniprot/P77318 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416015 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416015 RefSeq WP_001295684 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295684 STRING 511145.b1498 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1498&targetmode=cogs STRING COG3119 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3119&targetmode=cogs SUPFAM SSF53649 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53649 UniProtKB YDEN_ECOLI http://www.uniprot.org/uniprot/YDEN_ECOLI UniProtKB-AC P77318 http://www.uniprot.org/uniprot/P77318 charge swissprot:YDEN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDEN_ECOLI eggNOG COG3119 http://eggnogapi.embl.de/nog_data/html/tree/COG3119 eggNOG ENOG4105ENH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ENH epestfind swissprot:YDEN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDEN_ECOLI garnier swissprot:YDEN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDEN_ECOLI helixturnhelix swissprot:YDEN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDEN_ECOLI hmoment swissprot:YDEN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDEN_ECOLI iep swissprot:YDEN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDEN_ECOLI inforesidue swissprot:YDEN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDEN_ECOLI octanol swissprot:YDEN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDEN_ECOLI pepcoil swissprot:YDEN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDEN_ECOLI pepdigest swissprot:YDEN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDEN_ECOLI pepinfo swissprot:YDEN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDEN_ECOLI pepnet swissprot:YDEN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDEN_ECOLI pepstats swissprot:YDEN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDEN_ECOLI pepwheel swissprot:YDEN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDEN_ECOLI pepwindow swissprot:YDEN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDEN_ECOLI sigcleave swissprot:YDEN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDEN_ECOLI ## Database ID URL or Descriptions # CDD cd00427 Ribosomal_L29_HIP # DISRUPTION PHENOTYPE RL29_ECOLI Cells missing both S17 and L29 grow very slowly and have a rather unstable temperature-sensitive phenotype. {ECO 0000269|PubMed 12226666, ECO 0000269|PubMed 3926498}. # EcoGene EG10887 rpmC # FUNCTION RL29_ECOLI Binds 23S rRNA. It is not essential for growth. {ECO 0000269|PubMed 12226666, ECO 0000269|PubMed 6170935}. # FUNCTION RL29_ECOLI One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. Contacts trigger factor (PubMed 12226666). {ECO 0000269|PubMed 12226666}. # GO_component GO:0022625 cytosolic large ribosomal subunit; IDA:EcoCyc. # GO_function GO:0003735 structural constituent of ribosome; IEA:InterPro. # GO_function GO:0019843 rRNA binding; IEA:UniProtKB-KW. # GO_process GO:0006412 translation; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_function GO:0019843 rRNA binding # GOslim_process GO:0006412 translation # Gene3D 1.10.287.310 -; 1. # HAMAP MF_00374 Ribosomal_L29 # IntAct P0A7M6 33 # InterPro IPR001854 Ribosomal_L29 # InterPro IPR018254 Ribosomal_L29_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 M00179 Ribosome, archaea # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=7273.4; Method=MALDI; Range=1-63; Evidence={ECO:0000269|PubMed 10094780}; # Organism RL29_ECOLI Escherichia coli (strain K12) # PATRIC 32122056 VBIEscCol129921_3405 # PDB 1ML5 EM; 14.00 A; w=2-63 # PDB 2J28 EM; 8.00 A; X=1-63 # PDB 2RDO EM; 9.10 A; X=1-63 # PDB 2VRH EM; 19.00 A; D=1-63 # PDB 3BBX EM; 10.00 A; X=1-63 # PDB 3J45 EM; 9.50 A; Y=1-63 # PDB 3J46 EM; 10.10 A; Y=1-63 # PDB 3J5L EM; 6.60 A; Y=1-63 # PDB 3J7Z EM; 3.90 A; Y=1-63 # PDB 3J8G EM; 5.00 A; 1=1-63 # PDB 3J9Y EM; 3.90 A; Y=1-63 # PDB 3J9Z EM; 3.60 A; LW=1-63 # PDB 3JA1 EM; 3.60 A; L0=1-63 # PDB 3JBU EM; 3.64 A; 1=1-63 # PDB 3JBV EM; 3.32 A; 1=1-63 # PDB 3JCD EM; 3.70 A; Y=1-63 # PDB 3JCE EM; 3.20 A; Y=1-63 # PDB 3JCJ EM; 3.70 A; X=1-63 # PDB 3JCN EM; 4.60 A; Y=1-63 # PDB 4CSU EM; 5.50 A; 1=1-63 # PDB 4U1U X-ray; 2.95 A; BY/DY=1-63 # PDB 4U1V X-ray; 3.00 A; BY/DY=1-63 # PDB 4U20 X-ray; 2.90 A; BY/DY=1-63 # PDB 4U24 X-ray; 2.90 A; BY/DY=1-63 # PDB 4U25 X-ray; 2.90 A; BY/DY=1-63 # PDB 4U26 X-ray; 2.80 A; BY/DY=1-63 # PDB 4U27 X-ray; 2.80 A; BY/DY=1-63 # PDB 4UY8 EM; 3.80 A; Y=1-63 # PDB 4V47 EM; 12.30 A; AW=1-63 # PDB 4V48 EM; 11.50 A; AW=1-63 # PDB 4V4H X-ray; 3.46 A; BX/DX=1-63 # PDB 4V4Q X-ray; 3.46 A; BX/DX=1-63 # PDB 4V4V EM; 15.00 A; BW=1-60 # PDB 4V4W EM; 15.00 A; BW=1-60 # PDB 4V50 X-ray; 3.22 A; BY/DY=1-63 # PDB 4V52 X-ray; 3.21 A; BX/DX=1-63 # PDB 4V53 X-ray; 3.54 A; BX/DX=1-63 # PDB 4V54 X-ray; 3.30 A; BX/DX=1-63 # PDB 4V55 X-ray; 4.00 A; BX/DX=1-63 # PDB 4V56 X-ray; 3.93 A; BX/DX=1-63 # PDB 4V57 X-ray; 3.50 A; BX/DX=1-63 # PDB 4V5B X-ray; 3.74 A; AX/CX=1-63 # PDB 4V5H EM; 5.80 A; B1=1-63 # PDB 4V5Y X-ray; 4.45 A; BX/DX=1-63 # PDB 4V64 X-ray; 3.50 A; BX/DX=1-63 # PDB 4V65 EM; 9.00 A; BQ=1-63 # PDB 4V66 EM; 9.00 A; BQ=1-63 # PDB 4V69 EM; 6.70 A; BY=1-63 # PDB 4V6C X-ray; 3.19 A; BY/DY=1-63 # PDB 4V6D X-ray; 3.81 A; BY/DY=1-63 # PDB 4V6E X-ray; 3.71 A; BY/DY=1-63 # PDB 4V6K EM; 8.25 A; AZ=1-63 # PDB 4V6L EM; 13.20 A; BZ=1-63 # PDB 4V6M EM; 7.10 A; BY=1-63 # PDB 4V6N EM; 12.10 A; A0=1-63 # PDB 4V6O EM; 14.70 A; B0=1-63 # PDB 4V6P EM; 13.50 A; B0=1-63 # PDB 4V6Q EM; 11.50 A; B0=1-63 # PDB 4V6R EM; 11.50 A; B0=1-63 # PDB 4V6S EM; 13.10 A; A0=1-63 # PDB 4V6T EM; 8.30 A; BY=1-63 # PDB 4V6V EM; 9.80 A; B2=1-63 # PDB 4V6Y EM; 12.00 A; BY=1-63 # PDB 4V6Z EM; 12.00 A; BY=1-63 # PDB 4V70 EM; 17.00 A; BY=1-63 # PDB 4V71 EM; 20.00 A; BY=1-63 # PDB 4V72 EM; 13.00 A; BY=1-63 # PDB 4V73 EM; 15.00 A; BY=1-63 # PDB 4V74 EM; 17.00 A; BY=1-63 # PDB 4V75 EM; 12.00 A; BY=1-63 # PDB 4V76 EM; 17.00 A; BY=1-63 # PDB 4V77 EM; 17.00 A; BY=1-63 # PDB 4V78 EM; 20.00 A; BY=1-63 # PDB 4V79 EM; 15.00 A; BY=1-63 # PDB 4V7A EM; 9.00 A; BY=1-63 # PDB 4V7B EM; 6.80 A; BY=1-63 # PDB 4V7C EM; 7.60 A; B1=1-63 # PDB 4V7D EM; 7.60 A; A2=1-63 # PDB 4V7I EM; 9.60 A; AY=1-63 # PDB 4V7S X-ray; 3.25 A; BY/DY=1-63 # PDB 4V7T X-ray; 3.19 A; BY/DY=1-63 # PDB 4V7U X-ray; 3.10 A; BY/DY=1-63 # PDB 4V7V X-ray; 3.29 A; BY/DY=1-63 # PDB 4V85 X-ray; 3.20 A; 2=1-63 # PDB 4V89 X-ray; 3.70 A; B2=1-63 # PDB 4V9C X-ray; 3.30 A; BY/DY=1-63 # PDB 4V9D X-ray; 3.00 A; CY/DY=1-63 # PDB 4V9O X-ray; 2.90 A; AY/CY/EY/GY=1-63 # PDB 4V9P X-ray; 2.90 A; AY/CY/EY/GY=1-63 # PDB 4WF1 X-ray; 3.09 A; BY/DY=1-63 # PDB 4WOI X-ray; 3.00 A; BY/CY=1-63 # PDB 4WWW X-ray; 3.10 A; RY/YY=1-63 # PDB 4YBB X-ray; 2.10 A; CZ/DZ=2-63 # PDB 5ADY EM; 4.50 A; Y=1-63 # PDB 5AFI EM; 2.90 A; Y=1-63 # PDB 5AKA EM; 5.70 A; X=1-63 # PDB 5GAD EM; 3.70 A; Z=1-63 # PDB 5GAE EM; 3.33 A; Z=1-63 # PDB 5GAF EM; 4.30 A; Z=2-63 # PDB 5GAG EM; 3.80 A; Z=1-63 # PDB 5GAH EM; 3.80 A; Z=1-63 # PDB 5IQR EM; 3.00 A; Y=1-63 # PDB 5IT8 X-ray; 3.12 A; CZ/DZ=2-63 # PDB 5J5B X-ray; 2.80 A; CZ/DZ=2-63 # PDB 5J7L X-ray; 3.00 A; CZ/DZ=2-63 # PDB 5J88 X-ray; 3.32 A; CZ/DZ=2-63 # PDB 5J8A X-ray; 3.10 A; CZ/DZ=2-63 # PDB 5J91 X-ray; 2.96 A; CZ/DZ=2-63 # PDB 5JC9 X-ray; 3.03 A; CZ/DZ=2-63 # PDB 5JTE EM; 3.60 A; BY=1-63 # PDB 5JU8 EM; 3.60 A; BY=1-63 # PDB 5KCR EM; 3.60 A; 12=1-63 # PDB 5KCS EM; 3.90 A; 12=1-63 # PDB 5KPS EM; 3.90 A; Y=1-63 # PDB 5KPV EM; 4.10 A; X=1-63 # PDB 5KPW EM; 3.90 A; X=1-63 # PDB 5KPX EM; 3.90 A; X=1-63 # PDB 5L3P EM; 3.70 A; 2=1-63 # PIR B37519 R5EC29 # PROSITE PS00579 RIBOSOMAL_L29 # Pfam PF00831 Ribosomal_L29 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RL29_ECOLI 50S ribosomal protein L29 # RefSeq NP_417771 NC_000913.3 # RefSeq WP_000644741 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=Ref.1; Type=Miscellaneous discrepancy; Note=Exchange of two tryptic peptides.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ribosomal protein L29P family. {ECO 0000305}. # SUBUNIT RL29_ECOLI Part of the 50s ribosomal subunit. Contacts protein L23 (PubMed 2665813), trigger factor (PubMed 12226666) and protein nascent chains (PubMed 12756233). Might also contact SecE and probably does contact SecG when the SecYEG translocation complex is docked with the ribosome. {ECO 0000269|PubMed 12226666, ECO 0000269|PubMed 12756233, ECO 0000269|PubMed 16292303, ECO 0000269|PubMed 21499241, ECO 0000269|PubMed 2665813}. # SUPFAM SSF46561 SSF46561 # TIGRFAMs TIGR00012 L29 # eggNOG COG0255 LUCA # eggNOG ENOG41083MP Bacteria BLAST swissprot:RL29_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RL29_ECOLI BioCyc ECOL316407:JW3274-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3274-MONOMER BioCyc EcoCyc:EG10887-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10887-MONOMER BioCyc MetaCyc:EG10887-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10887-MONOMER COG COG0255 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0255 DIP DIP-47911N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47911N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1016/S0092-8674(03)00427-6 http://dx.doi.org/10.1016/S0092-8674(03)00427-6 DOI 10.1016/j.celrep.2014.09.011 http://dx.doi.org/10.1016/j.celrep.2014.09.011 DOI 10.1021/bi00435a071 http://dx.doi.org/10.1021/bi00435a071 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature01047 http://dx.doi.org/10.1038/nature01047 DOI 10.1038/nature04133 http://dx.doi.org/10.1038/nature04133 DOI 10.1038/nsmb.2026 http://dx.doi.org/10.1038/nsmb.2026 DOI 10.1083/jcb.200302130 http://dx.doi.org/10.1083/jcb.200302130 DOI 10.1093/nar/13.12.4521 http://dx.doi.org/10.1093/nar/13.12.4521 DOI 10.1093/nar/9.17.4285 http://dx.doi.org/10.1093/nar/9.17.4285 DOI 10.1111/j.1432-1033.1985.tb09048.x http://dx.doi.org/10.1111/j.1432-1033.1985.tb09048.x DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pbio.1001866 http://dx.doi.org/10.1371/journal.pbio.1001866 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X02613 http://www.ebi.ac.uk/ena/data/view/X02613 EchoBASE EB0880 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0880 EcoGene EG10887 http://www.ecogene.org/geneInfo.php?eg_id=EG10887 EnsemblBacteria AAC76337 http://www.ensemblgenomes.org/id/AAC76337 EnsemblBacteria AAC76337 http://www.ensemblgenomes.org/id/AAC76337 EnsemblBacteria BAE77979 http://www.ensemblgenomes.org/id/BAE77979 EnsemblBacteria BAE77979 http://www.ensemblgenomes.org/id/BAE77979 EnsemblBacteria BAE77979 http://www.ensemblgenomes.org/id/BAE77979 EnsemblBacteria b3312 http://www.ensemblgenomes.org/id/b3312 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0022625 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022625 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 Gene3D 1.10.287.310 http://www.cathdb.info/version/latest/superfamily/1.10.287.310 GeneID 947807 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947807 HAMAP MF_00374 http://hamap.expasy.org/unirule/MF_00374 HOGENOM HOG000248754 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000248754&db=HOGENOM6 InParanoid P0A7M6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7M6 IntAct P0A7M6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7M6* InterPro IPR001854 http://www.ebi.ac.uk/interpro/entry/IPR001854 InterPro IPR018254 http://www.ebi.ac.uk/interpro/entry/IPR018254 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW3274 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3274 KEGG_Gene eco:b3312 http://www.genome.jp/dbget-bin/www_bget?eco:b3312 KEGG_Orthology KO:K02904 http://www.genome.jp/dbget-bin/www_bget?KO:K02904 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 MINT MINT-1240640 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1240640 OMA MRMQAST http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MRMQAST PDB 1ML5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ML5 PDB 2J28 http://www.ebi.ac.uk/pdbe-srv/view/entry/2J28 PDB 2RDO http://www.ebi.ac.uk/pdbe-srv/view/entry/2RDO PDB 2VRH http://www.ebi.ac.uk/pdbe-srv/view/entry/2VRH PDB 3BBX http://www.ebi.ac.uk/pdbe-srv/view/entry/3BBX PDB 3J45 http://www.ebi.ac.uk/pdbe-srv/view/entry/3J45 PDB 3J46 http://www.ebi.ac.uk/pdbe-srv/view/entry/3J46 PDB 3J5L http://www.ebi.ac.uk/pdbe-srv/view/entry/3J5L PDB 3J7Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J7Z PDB 3J8G http://www.ebi.ac.uk/pdbe-srv/view/entry/3J8G PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 4CSU http://www.ebi.ac.uk/pdbe-srv/view/entry/4CSU PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4UY8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4UY8 PDB 4V47 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V47 PDB 4V48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V48 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5ADY http://www.ebi.ac.uk/pdbe-srv/view/entry/5ADY PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5AKA http://www.ebi.ac.uk/pdbe-srv/view/entry/5AKA PDB 5GAD http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAD PDB 5GAE http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAE PDB 5GAF http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAF PDB 5GAG http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAG PDB 5GAH http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAH PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 1ML5 http://www.ebi.ac.uk/pdbsum/1ML5 PDBsum 2J28 http://www.ebi.ac.uk/pdbsum/2J28 PDBsum 2RDO http://www.ebi.ac.uk/pdbsum/2RDO PDBsum 2VRH http://www.ebi.ac.uk/pdbsum/2VRH PDBsum 3BBX http://www.ebi.ac.uk/pdbsum/3BBX PDBsum 3J45 http://www.ebi.ac.uk/pdbsum/3J45 PDBsum 3J46 http://www.ebi.ac.uk/pdbsum/3J46 PDBsum 3J5L http://www.ebi.ac.uk/pdbsum/3J5L PDBsum 3J7Z http://www.ebi.ac.uk/pdbsum/3J7Z PDBsum 3J8G http://www.ebi.ac.uk/pdbsum/3J8G PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 4CSU http://www.ebi.ac.uk/pdbsum/4CSU PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4UY8 http://www.ebi.ac.uk/pdbsum/4UY8 PDBsum 4V47 http://www.ebi.ac.uk/pdbsum/4V47 PDBsum 4V48 http://www.ebi.ac.uk/pdbsum/4V48 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5ADY http://www.ebi.ac.uk/pdbsum/5ADY PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5AKA http://www.ebi.ac.uk/pdbsum/5AKA PDBsum 5GAD http://www.ebi.ac.uk/pdbsum/5GAD PDBsum 5GAE http://www.ebi.ac.uk/pdbsum/5GAE PDBsum 5GAF http://www.ebi.ac.uk/pdbsum/5GAF PDBsum 5GAG http://www.ebi.ac.uk/pdbsum/5GAG PDBsum 5GAH http://www.ebi.ac.uk/pdbsum/5GAH PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PROSITE PS00579 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00579 PSORT swissprot:RL29_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RL29_ECOLI PSORT-B swissprot:RL29_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RL29_ECOLI PSORT2 swissprot:RL29_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RL29_ECOLI Pfam PF00831 http://pfam.xfam.org/family/PF00831 Phobius swissprot:RL29_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RL29_ECOLI PhylomeDB P0A7M6 http://phylomedb.org/?seqid=P0A7M6 ProteinModelPortal P0A7M6 http://www.proteinmodelportal.org/query/uniprot/P0A7M6 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 1092361 http://www.ncbi.nlm.nih.gov/pubmed/1092361 PubMed 12226666 http://www.ncbi.nlm.nih.gov/pubmed/12226666 PubMed 12756233 http://www.ncbi.nlm.nih.gov/pubmed/12756233 PubMed 12809609 http://www.ncbi.nlm.nih.gov/pubmed/12809609 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16292303 http://www.ncbi.nlm.nih.gov/pubmed/16292303 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21499241 http://www.ncbi.nlm.nih.gov/pubmed/21499241 PubMed 24844575 http://www.ncbi.nlm.nih.gov/pubmed/24844575 PubMed 25310980 http://www.ncbi.nlm.nih.gov/pubmed/25310980 PubMed 2665813 http://www.ncbi.nlm.nih.gov/pubmed/2665813 PubMed 3892488 http://www.ncbi.nlm.nih.gov/pubmed/3892488 PubMed 3926498 http://www.ncbi.nlm.nih.gov/pubmed/3926498 PubMed 6170935 http://www.ncbi.nlm.nih.gov/pubmed/6170935 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417771 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417771 RefSeq WP_000644741 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000644741 SMR P0A7M6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7M6 STRING 511145.b3312 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3312&targetmode=cogs STRING COG0255 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0255&targetmode=cogs SUPFAM SSF46561 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46561 TIGRFAMs TIGR00012 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00012 UniProtKB RL29_ECOLI http://www.uniprot.org/uniprot/RL29_ECOLI UniProtKB-AC P0A7M6 http://www.uniprot.org/uniprot/P0A7M6 charge swissprot:RL29_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RL29_ECOLI eggNOG COG0255 http://eggnogapi.embl.de/nog_data/html/tree/COG0255 eggNOG ENOG41083MP http://eggnogapi.embl.de/nog_data/html/tree/ENOG41083MP epestfind swissprot:RL29_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RL29_ECOLI garnier swissprot:RL29_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RL29_ECOLI helixturnhelix swissprot:RL29_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RL29_ECOLI hmoment swissprot:RL29_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RL29_ECOLI iep swissprot:RL29_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RL29_ECOLI inforesidue swissprot:RL29_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RL29_ECOLI octanol swissprot:RL29_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RL29_ECOLI pepcoil swissprot:RL29_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RL29_ECOLI pepdigest swissprot:RL29_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RL29_ECOLI pepinfo swissprot:RL29_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RL29_ECOLI pepnet swissprot:RL29_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RL29_ECOLI pepstats swissprot:RL29_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RL29_ECOLI pepwheel swissprot:RL29_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RL29_ECOLI pepwindow swissprot:RL29_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RL29_ECOLI sigcleave swissprot:RL29_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RL29_ECOLI ## Database ID URL or Descriptions # AltName UVRB_ECOLI Excinuclease ABC subunit B # BioGrid 4259957 128 # DOMAIN UVRB_ECOLI The beta-hairpin motif is involved in DNA binding. # EcoGene EG11062 uvrB # FUNCTION UVRB_ECOLI The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage. {ECO 0000269|PubMed 12145219}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_component GO:0009380 excinuclease repair complex; IDA:UniProtKB. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0004386 helicase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0009381 excinuclease ABC activity; IEA:UniProtKB-HAMAP. # GO_process GO:0006289 nucleotide-excision repair; IEA:UniProtKB-HAMAP. # GO_process GO:0009432 SOS response; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004386 helicase activity # GOslim_function GO:0004518 nuclease activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # Gene3D 3.40.50.300 -; 4. # Gene3D 4.10.860.10 -; 1. # HAMAP MF_00204 UvrB # INDUCTION Induced 1.5-fold by hydroxyurea. {ECO:0000269|PubMed 20005847}. # INTERACTION UVRB_ECOLI P0AFY8 seqA; NbExp=2; IntAct=EBI-552176, EBI-552553; P76373 ugd; NbExp=2; IntAct=EBI-552176, EBI-1120497; # IntAct P0A8F8 31 # InterPro IPR001650 Helicase_C # InterPro IPR001943 UVR_dom # InterPro IPR004807 UvrB # InterPro IPR006935 Helicase/UvrB_N # InterPro IPR014001 Helicase_ATP-bd # InterPro IPR024759 UvrB_YAD/RRR_dom # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko03420 Nucleotide excision repair # MISCELLANEOUS According to PubMed 3515321, a cleaved form of the protein was observed that resulted from the removal of about 40 amino acids from the C-terminus of the protein. The exact cleavage site being unknown, it was proposed to be between Lys-630 and Ala- 631. There was no indication that cleavage occured in vivo and therefore it is not known if it has any physiological significance. # Organism UVRB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR24029 PTHR24029 # PATRIC 32116759 VBIEscCol129921_0805 # PDB 1E52 NMR; -; A/B=619-673 # PDB 1QOJ X-ray; 3.00 A; A/B=619-673 # PIR A93613 BVECUB # PROSITE PS50151 UVR # PROSITE PS51192 HELICASE_ATP_BIND_1 # PROSITE PS51194 HELICASE_CTER # Pfam PF00271 Helicase_C # Pfam PF02151 UVR # Pfam PF04851 ResIII # Pfam PF12344 UvrB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UVRB_ECOLI UvrABC system protein B # RefSeq NP_415300 NC_000913.3 # RefSeq WP_000042533 NZ_LN832404.1 # SIMILARITY Belongs to the UvrB family. {ECO 0000305}. # SIMILARITY Contains 1 UVR domain. {ECO 0000305}. # SIMILARITY Contains 1 helicase ATP-binding domain. {ECO 0000305}. # SIMILARITY Contains 1 helicase C-terminal domain. {ECO 0000305}. # SMART SM00487 DEXDc # SMART SM00490 HELICc # SUBCELLULAR LOCATION UVRB_ECOLI Cytoplasm. # SUBUNIT UVRB_ECOLI Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex. # SUPFAM SSF46600 SSF46600 # SUPFAM SSF52540 SSF52540; 3 # TIGRFAMs TIGR00631 uvrb # eggNOG COG0556 LUCA # eggNOG ENOG4105CCW Bacteria BLAST swissprot:UVRB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UVRB_ECOLI BioCyc ECOL316407:JW0762-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0762-MONOMER BioCyc EcoCyc:EG11062-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11062-MONOMER BioCyc MetaCyc:EG11062-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11062-MONOMER COG COG0556 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0556 DIP DIP-48012N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48012N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/S0014-5793(99)00542-6 http://dx.doi.org/10.1016/S0014-5793(99)00542-6 DOI 10.1016/S0014-5793(99)01690-7 http://dx.doi.org/10.1016/S0014-5793(99)01690-7 DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/emboj/20.21.6140 http://dx.doi.org/10.1093/emboj/20.21.6140 DOI 10.1093/emboj/cdf396 http://dx.doi.org/10.1093/emboj/cdf396 DOI 10.1093/nar/14.6.2637 http://dx.doi.org/10.1093/nar/14.6.2637 DOI 10.1093/nar/14.7.2877 http://dx.doi.org/10.1093/nar/14.7.2877 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X03678 http://www.ebi.ac.uk/ena/data/view/X03678 EMBL X03722 http://www.ebi.ac.uk/ena/data/view/X03722 EchoBASE EB1055 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1055 EcoGene EG11062 http://www.ecogene.org/geneInfo.php?eg_id=EG11062 EnsemblBacteria AAC73866 http://www.ensemblgenomes.org/id/AAC73866 EnsemblBacteria AAC73866 http://www.ensemblgenomes.org/id/AAC73866 EnsemblBacteria BAA35437 http://www.ensemblgenomes.org/id/BAA35437 EnsemblBacteria BAA35437 http://www.ensemblgenomes.org/id/BAA35437 EnsemblBacteria BAA35437 http://www.ensemblgenomes.org/id/BAA35437 EnsemblBacteria b0779 http://www.ensemblgenomes.org/id/b0779 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0009380 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009380 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004386 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0009381 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009381 GO_process GO:0006289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006289 GO_process GO:0009432 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009432 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004386 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 Gene3D 4.10.860.10 http://www.cathdb.info/version/latest/superfamily/4.10.860.10 GeneID 945385 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945385 HAMAP MF_00204 http://hamap.expasy.org/unirule/MF_00204 HOGENOM HOG000073580 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000073580&db=HOGENOM6 InParanoid P0A8F8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8F8 IntAct P0A8F8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8F8* InterPro IPR001650 http://www.ebi.ac.uk/interpro/entry/IPR001650 InterPro IPR001943 http://www.ebi.ac.uk/interpro/entry/IPR001943 InterPro IPR004807 http://www.ebi.ac.uk/interpro/entry/IPR004807 InterPro IPR006935 http://www.ebi.ac.uk/interpro/entry/IPR006935 InterPro IPR014001 http://www.ebi.ac.uk/interpro/entry/IPR014001 InterPro IPR024759 http://www.ebi.ac.uk/interpro/entry/IPR024759 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW0762 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0762 KEGG_Gene eco:b0779 http://www.genome.jp/dbget-bin/www_bget?eco:b0779 KEGG_Orthology KO:K03702 http://www.genome.jp/dbget-bin/www_bget?KO:K03702 KEGG_Pathway ko03420 http://www.genome.jp/kegg-bin/show_pathway?ko03420 MINT MINT-1244062 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1244062 OMA QEYVDRM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QEYVDRM PANTHER PTHR24029 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24029 PDB 1E52 http://www.ebi.ac.uk/pdbe-srv/view/entry/1E52 PDB 1QOJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1QOJ PDBsum 1E52 http://www.ebi.ac.uk/pdbsum/1E52 PDBsum 1QOJ http://www.ebi.ac.uk/pdbsum/1QOJ PROSITE PS50151 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50151 PROSITE PS51192 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51192 PROSITE PS51194 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51194 PSORT swissprot:UVRB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UVRB_ECOLI PSORT-B swissprot:UVRB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UVRB_ECOLI PSORT2 swissprot:UVRB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UVRB_ECOLI Pfam PF00271 http://pfam.xfam.org/family/PF00271 Pfam PF02151 http://pfam.xfam.org/family/PF02151 Pfam PF04851 http://pfam.xfam.org/family/PF04851 Pfam PF12344 http://pfam.xfam.org/family/PF12344 Phobius swissprot:UVRB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UVRB_ECOLI PhylomeDB P0A8F8 http://phylomedb.org/?seqid=P0A8F8 ProteinModelPortal P0A8F8 http://www.proteinmodelportal.org/query/uniprot/P0A8F8 PubMed 10371161 http://www.ncbi.nlm.nih.gov/pubmed/10371161 PubMed 10631326 http://www.ncbi.nlm.nih.gov/pubmed/10631326 PubMed 11689453 http://www.ncbi.nlm.nih.gov/pubmed/11689453 PubMed 12145219 http://www.ncbi.nlm.nih.gov/pubmed/12145219 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 3008099 http://www.ncbi.nlm.nih.gov/pubmed/3008099 PubMed 3515321 http://www.ncbi.nlm.nih.gov/pubmed/3515321 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_415300 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415300 RefSeq WP_000042533 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000042533 SMART SM00487 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00487 SMART SM00490 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00490 SMR P0A8F8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8F8 STRING 511145.b0779 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0779&targetmode=cogs STRING COG0556 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0556&targetmode=cogs SUPFAM SSF46600 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46600 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR00631 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00631 UniProtKB UVRB_ECOLI http://www.uniprot.org/uniprot/UVRB_ECOLI UniProtKB-AC P0A8F8 http://www.uniprot.org/uniprot/P0A8F8 charge swissprot:UVRB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UVRB_ECOLI eggNOG COG0556 http://eggnogapi.embl.de/nog_data/html/tree/COG0556 eggNOG ENOG4105CCW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CCW epestfind swissprot:UVRB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UVRB_ECOLI garnier swissprot:UVRB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UVRB_ECOLI helixturnhelix swissprot:UVRB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UVRB_ECOLI hmoment swissprot:UVRB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UVRB_ECOLI iep swissprot:UVRB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UVRB_ECOLI inforesidue swissprot:UVRB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UVRB_ECOLI octanol swissprot:UVRB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UVRB_ECOLI pepcoil swissprot:UVRB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UVRB_ECOLI pepdigest swissprot:UVRB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UVRB_ECOLI pepinfo swissprot:UVRB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UVRB_ECOLI pepnet swissprot:UVRB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UVRB_ECOLI pepstats swissprot:UVRB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UVRB_ECOLI pepwheel swissprot:UVRB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UVRB_ECOLI pepwindow swissprot:UVRB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UVRB_ECOLI sigcleave swissprot:UVRB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UVRB_ECOLI ## Database ID URL or Descriptions # BioGrid 4261598 147 # EcoGene EG14024 yebV # INTERACTION YEBV_ECOLI P0A6R3 fis; NbExp=3; IntAct=EBI-9126792, EBI-550170; P76268 kdgR; NbExp=3; IntAct=EBI-9126792, EBI-1123676; P0ACP7 purR; NbExp=4; IntAct=EBI-9126792, EBI-1115258; P0A8G9 xseB; NbExp=4; IntAct=EBI-9126792, EBI-1116872; # IntAct P64503 6 # InterPro IPR009950 DUF1480 # Organism YEBV_ECOLI Escherichia coli (strain K12) # PATRIC 32118993 VBIEscCol129921_1914 # Pfam PF07351 DUF1480 # ProDom PD060427 DUF1480 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEBV_ECOLI Uncharacterized protein YebV # RefSeq NP_416350 NC_000913.3 # RefSeq WP_001295499 NZ_LN832404.1 # eggNOG ENOG4105WT8 Bacteria # eggNOG ENOG411247I LUCA BLAST swissprot:YEBV_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEBV_ECOLI BioCyc ECOL316407:JW5302-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5302-MONOMER BioCyc EcoCyc:G7009-MONOMER http://biocyc.org/getid?id=EcoCyc:G7009-MONOMER DIP DIP-48173N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48173N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3778 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3778 EcoGene EG14024 http://www.ecogene.org/geneInfo.php?eg_id=EG14024 EnsemblBacteria AAC74906 http://www.ensemblgenomes.org/id/AAC74906 EnsemblBacteria AAC74906 http://www.ensemblgenomes.org/id/AAC74906 EnsemblBacteria BAE76541 http://www.ensemblgenomes.org/id/BAE76541 EnsemblBacteria BAE76541 http://www.ensemblgenomes.org/id/BAE76541 EnsemblBacteria BAE76541 http://www.ensemblgenomes.org/id/BAE76541 EnsemblBacteria b1836 http://www.ensemblgenomes.org/id/b1836 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946347 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946347 HOGENOM HOG000219283 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219283&db=HOGENOM6 IntAct P64503 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P64503* InterPro IPR009950 http://www.ebi.ac.uk/interpro/entry/IPR009950 KEGG_Gene ecj:JW5302 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5302 KEGG_Gene eco:b1836 http://www.genome.jp/dbget-bin/www_bget?eco:b1836 OMA VLYREHY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VLYREHY PSORT swissprot:YEBV_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEBV_ECOLI PSORT-B swissprot:YEBV_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEBV_ECOLI PSORT2 swissprot:YEBV_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEBV_ECOLI Pfam PF07351 http://pfam.xfam.org/family/PF07351 Phobius swissprot:YEBV_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEBV_ECOLI ProteinModelPortal P64503 http://www.proteinmodelportal.org/query/uniprot/P64503 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416350 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416350 RefSeq WP_001295499 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295499 STRING 511145.b1836 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1836&targetmode=cogs UniProtKB YEBV_ECOLI http://www.uniprot.org/uniprot/YEBV_ECOLI UniProtKB-AC P64503 http://www.uniprot.org/uniprot/P64503 charge swissprot:YEBV_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEBV_ECOLI eggNOG ENOG4105WT8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105WT8 eggNOG ENOG411247I http://eggnogapi.embl.de/nog_data/html/tree/ENOG411247I epestfind swissprot:YEBV_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEBV_ECOLI garnier swissprot:YEBV_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEBV_ECOLI helixturnhelix swissprot:YEBV_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEBV_ECOLI hmoment swissprot:YEBV_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEBV_ECOLI iep swissprot:YEBV_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEBV_ECOLI inforesidue swissprot:YEBV_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEBV_ECOLI octanol swissprot:YEBV_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEBV_ECOLI pepcoil swissprot:YEBV_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEBV_ECOLI pepdigest swissprot:YEBV_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEBV_ECOLI pepinfo swissprot:YEBV_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEBV_ECOLI pepnet swissprot:YEBV_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEBV_ECOLI pepstats swissprot:YEBV_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEBV_ECOLI pepwheel swissprot:YEBV_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEBV_ECOLI pepwindow swissprot:YEBV_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEBV_ECOLI sigcleave swissprot:YEBV_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEBV_ECOLI ## Database ID URL or Descriptions # AltName Arginosuccinase {ECO:0000255|HAMAP-Rule MF_00006} # BioGrid 4263466 10 # CATALYTIC ACTIVITY 2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. {ECO:0000255|HAMAP-Rule MF_00006}. # CDD cd01359 Argininosuccinate_lyase # EcoGene EG11223 argH # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0004056 argininosuccinate lyase activity; IDA:EcoCyc. # GO_process GO:0006526 arginine biosynthetic process; IBA:GO_Central. # GO_process GO:0042450 arginine biosynthetic process via ornithine; IBA:GO_Central. # GO_process GO:0051262 protein tetramerization; IBA:GO_Central. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 1.10.275.10 -; 1. # HAMAP MF_00006 Arg_succ_lyase # InterPro IPR000362 Fumarate_lyase_fam # InterPro IPR008948 L-Aspartase-like # InterPro IPR009049 Argininosuccinate_lyase # InterPro IPR020557 Fumarate_lyase_CS # InterPro IPR022761 Fumarate_lyase_N # InterPro IPR024083 Fumarase/histidase_N # InterPro IPR029419 Arg_succ_lyase_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00250 Alanine, aspartate and glutamate metabolism # KEGG_Pathway ko00330 Arginine and proline metabolism # Organism ARLY_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11444 PTHR11444 # PANTHER PTHR11444:SF3 PTHR11444:SF3 # PATHWAY Amino-acid biosynthesis; L-arginine biosynthesis; L- arginine from L-ornithine and carbamoyl phosphate: step 3/3. {ECO 0000255|HAMAP-Rule:MF_00006}. # PATRIC 32123441 VBIEscCol129921_4081 # PDB 1TJ7 X-ray; 2.44 A; A/B=1-457 # PIR C65203 C65203 # PRINTS PR00149 FUMRATELYASE # PROSITE PS00163 FUMARATE_LYASES # Pfam PF00206 Lyase_1 # Pfam PF14698 ASL_C2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Argininosuccinate lyase {ECO:0000255|HAMAP-Rule MF_00006} # RefSeq NP_418395 NC_000913.3 # RefSeq WP_001230087 NZ_LN832404.1 # SIMILARITY Belongs to the lyase 1 family. Argininosuccinate lyase subfamily. {ECO:0000255|HAMAP-Rule MF_00006}. # SUBCELLULAR LOCATION ARLY_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF48557 SSF48557 # TIGRFAMs TIGR00838 argH # UniPathway UPA00068 UER00114 # eggNOG COG0165 LUCA # eggNOG ENOG4105CH7 Bacteria BLAST swissprot:ARLY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARLY_ECOLI BioCyc ECOL316407:JW3932-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3932-MONOMER BioCyc EcoCyc:ARGSUCCINLYA-MONOMER http://biocyc.org/getid?id=EcoCyc:ARGSUCCINLYA-MONOMER BioCyc MetaCyc:ARGSUCCINLYA-MONOMER http://biocyc.org/getid?id=MetaCyc:ARGSUCCINLYA-MONOMER COG COG0165 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0165 DIP DIP-9142N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9142N DOI 10.1016/0378-1119(88)90030-3 http://dx.doi.org/10.1016/0378-1119(88)90030-3 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/10.19.5935 http://dx.doi.org/10.1093/nar/10.19.5935 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.3.2.1 {ECO:0000255|HAMAP-Rule:MF_00006} http://www.genome.jp/dbget-bin/www_bget?EC:4.3.2.1 {ECO:0000255|HAMAP-Rule:MF_00006} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01590 http://www.ebi.ac.uk/ena/data/view/J01590 EMBL M21446 http://www.ebi.ac.uk/ena/data/view/M21446 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 4.3.2.1 {ECO:0000255|HAMAP-Rule:MF_00006} http://enzyme.expasy.org/EC/4.3.2.1 {ECO:0000255|HAMAP-Rule:MF_00006} EchoBASE EB1205 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1205 EcoGene EG11223 http://www.ecogene.org/geneInfo.php?eg_id=EG11223 EnsemblBacteria AAC76942 http://www.ensemblgenomes.org/id/AAC76942 EnsemblBacteria AAC76942 http://www.ensemblgenomes.org/id/AAC76942 EnsemblBacteria BAE77351 http://www.ensemblgenomes.org/id/BAE77351 EnsemblBacteria BAE77351 http://www.ensemblgenomes.org/id/BAE77351 EnsemblBacteria BAE77351 http://www.ensemblgenomes.org/id/BAE77351 EnsemblBacteria b3960 http://www.ensemblgenomes.org/id/b3960 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004056 GO_process GO:0006526 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006526 GO_process GO:0042450 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042450 GO_process GO:0051262 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051262 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 1.10.275.10 http://www.cathdb.info/version/latest/superfamily/1.10.275.10 GeneID 948463 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948463 HAMAP MF_00006 http://hamap.expasy.org/unirule/MF_00006 HOGENOM HOG000242744 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000242744&db=HOGENOM6 InParanoid P11447 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P11447 IntEnz 4.3.2.1 {ECO:0000255|HAMAP-Rule:MF_00006} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.3.2.1 {ECO:0000255|HAMAP-Rule:MF_00006} InterPro IPR000362 http://www.ebi.ac.uk/interpro/entry/IPR000362 InterPro IPR008948 http://www.ebi.ac.uk/interpro/entry/IPR008948 InterPro IPR009049 http://www.ebi.ac.uk/interpro/entry/IPR009049 InterPro IPR020557 http://www.ebi.ac.uk/interpro/entry/IPR020557 InterPro IPR022761 http://www.ebi.ac.uk/interpro/entry/IPR022761 InterPro IPR024083 http://www.ebi.ac.uk/interpro/entry/IPR024083 InterPro IPR029419 http://www.ebi.ac.uk/interpro/entry/IPR029419 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3932 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3932 KEGG_Gene eco:b3960 http://www.genome.jp/dbget-bin/www_bget?eco:b3960 KEGG_Orthology KO:K01755 http://www.genome.jp/dbget-bin/www_bget?KO:K01755 KEGG_Pathway ko00250 http://www.genome.jp/kegg-bin/show_pathway?ko00250 KEGG_Pathway ko00330 http://www.genome.jp/kegg-bin/show_pathway?ko00330 KEGG_Reaction rn:R01086 http://www.genome.jp/dbget-bin/www_bget?rn:R01086 OMA AHHLMAY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AHHLMAY PANTHER PTHR11444 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11444 PANTHER PTHR11444:SF3 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11444:SF3 PDB 1TJ7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1TJ7 PDBsum 1TJ7 http://www.ebi.ac.uk/pdbsum/1TJ7 PRINTS PR00149 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00149 PROSITE PS00163 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00163 PSORT swissprot:ARLY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARLY_ECOLI PSORT-B swissprot:ARLY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARLY_ECOLI PSORT2 swissprot:ARLY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARLY_ECOLI Pfam PF00206 http://pfam.xfam.org/family/PF00206 Pfam PF14698 http://pfam.xfam.org/family/PF14698 Phobius swissprot:ARLY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARLY_ECOLI PhylomeDB P11447 http://phylomedb.org/?seqid=P11447 ProteinModelPortal P11447 http://www.proteinmodelportal.org/query/uniprot/P11447 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2851495 http://www.ncbi.nlm.nih.gov/pubmed/2851495 PubMed 6292860 http://www.ncbi.nlm.nih.gov/pubmed/6292860 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418395 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418395 RefSeq WP_001230087 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001230087 SMR P11447 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P11447 STRING 511145.b3960 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3960&targetmode=cogs STRING COG0165 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0165&targetmode=cogs SUPFAM SSF48557 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48557 TIGRFAMs TIGR00838 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00838 UniProtKB ARLY_ECOLI http://www.uniprot.org/uniprot/ARLY_ECOLI UniProtKB-AC P11447 http://www.uniprot.org/uniprot/P11447 charge swissprot:ARLY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARLY_ECOLI eggNOG COG0165 http://eggnogapi.embl.de/nog_data/html/tree/COG0165 eggNOG ENOG4105CH7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CH7 epestfind swissprot:ARLY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARLY_ECOLI garnier swissprot:ARLY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARLY_ECOLI helixturnhelix swissprot:ARLY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARLY_ECOLI hmoment swissprot:ARLY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARLY_ECOLI iep swissprot:ARLY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARLY_ECOLI inforesidue swissprot:ARLY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARLY_ECOLI octanol swissprot:ARLY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARLY_ECOLI pepcoil swissprot:ARLY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARLY_ECOLI pepdigest swissprot:ARLY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARLY_ECOLI pepinfo swissprot:ARLY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARLY_ECOLI pepnet swissprot:ARLY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARLY_ECOLI pepstats swissprot:ARLY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARLY_ECOLI pepwheel swissprot:ARLY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARLY_ECOLI pepwindow swissprot:ARLY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARLY_ECOLI sigcleave swissprot:ARLY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARLY_ECOLI ## Database ID URL or Descriptions # BioGrid 4259828 18 # EcoGene EG11401 psiF # InterPro IPR011690 P_starv_induced_PsiF # Organism PSIF_ECOLI Escherichia coli (strain K12) # PATRIC 32115909 VBIEscCol129921_0396 # Pfam PF07769 PsiF_repeat; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PSIF_ECOLI Phosphate starvation-inducible protein PsiF # RefSeq NP_414918 NC_000913.3 # RefSeq WP_001295332 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18108.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # eggNOG ENOG4105VIF Bacteria # eggNOG ENOG41121V4 LUCA BLAST swissprot:PSIF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PSIF_ECOLI BioCyc ECOL316407:JW5054-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5054-MONOMER BioCyc EcoCyc:EG11401-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11401-MONOMER DOI 10.1016/0378-1119(86)90050-8 http://dx.doi.org/10.1016/0378-1119(86)90050-8 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M13345 http://www.ebi.ac.uk/ena/data/view/M13345 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB1373 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1373 EcoGene EG11401 http://www.ecogene.org/geneInfo.php?eg_id=EG11401 EnsemblBacteria AAC73487 http://www.ensemblgenomes.org/id/AAC73487 EnsemblBacteria AAC73487 http://www.ensemblgenomes.org/id/AAC73487 EnsemblBacteria BAE76165 http://www.ensemblgenomes.org/id/BAE76165 EnsemblBacteria BAE76165 http://www.ensemblgenomes.org/id/BAE76165 EnsemblBacteria BAE76165 http://www.ensemblgenomes.org/id/BAE76165 EnsemblBacteria b0384 http://www.ensemblgenomes.org/id/b0384 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945040 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945040 HOGENOM HOG000261255 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261255&db=HOGENOM6 InParanoid P0AFM4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFM4 InterPro IPR011690 http://www.ebi.ac.uk/interpro/entry/IPR011690 KEGG_Gene ecj:JW5054 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5054 KEGG_Gene eco:b0384 http://www.genome.jp/dbget-bin/www_bget?eco:b0384 OMA KMADCNK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KMADCNK PSORT swissprot:PSIF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PSIF_ECOLI PSORT-B swissprot:PSIF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PSIF_ECOLI PSORT2 swissprot:PSIF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PSIF_ECOLI Pfam PF07769 http://pfam.xfam.org/family/PF07769 Phobius swissprot:PSIF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PSIF_ECOLI ProteinModelPortal P0AFM4 http://www.proteinmodelportal.org/query/uniprot/P0AFM4 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2160940 http://www.ncbi.nlm.nih.gov/pubmed/2160940 PubMed 3533724 http://www.ncbi.nlm.nih.gov/pubmed/3533724 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414918 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414918 RefSeq WP_001295332 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295332 STRING 511145.b0384 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0384&targetmode=cogs UniProtKB PSIF_ECOLI http://www.uniprot.org/uniprot/PSIF_ECOLI UniProtKB-AC P0AFM4 http://www.uniprot.org/uniprot/P0AFM4 charge swissprot:PSIF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PSIF_ECOLI eggNOG ENOG4105VIF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VIF eggNOG ENOG41121V4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41121V4 epestfind swissprot:PSIF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PSIF_ECOLI garnier swissprot:PSIF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PSIF_ECOLI helixturnhelix swissprot:PSIF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PSIF_ECOLI hmoment swissprot:PSIF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PSIF_ECOLI iep swissprot:PSIF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PSIF_ECOLI inforesidue swissprot:PSIF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PSIF_ECOLI octanol swissprot:PSIF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PSIF_ECOLI pepcoil swissprot:PSIF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PSIF_ECOLI pepdigest swissprot:PSIF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PSIF_ECOLI pepinfo swissprot:PSIF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PSIF_ECOLI pepnet swissprot:PSIF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PSIF_ECOLI pepstats swissprot:PSIF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PSIF_ECOLI pepwheel swissprot:PSIF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PSIF_ECOLI pepwindow swissprot:PSIF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PSIF_ECOLI sigcleave swissprot:PSIF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PSIF_ECOLI ## Database ID URL or Descriptions # BioGrid 4260522 5 # CDD cd06261 TM_PBP2 # EcoGene EG10007 hisM # FUNCTION HISM_ECOLI Part of the histidine permease ABC transporter. Also part of a lysine/arginine/ornithine transporter. Probably responsible for the translocation of the substrate across the membrane. Required to relay the ATPase-inducing signal from the solute-binding protein to HisP (By similarity). {ECO 0000250}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005215 transporter activity; IEA:InterPro. # GO_process GO:0006865 amino acid transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006810 transport # Gene3D 1.10.3720.10 -; 1. # InterPro IPR000515 MetI-like # InterPro IPR010065 AA_ABC_transptr_permease_3TM # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00225 Lysine/arginine/ornithine transport system # KEGG_Brite ko02000 M00226 Histidine transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism HISM_ECOLI Escherichia coli (strain K12) # PATRIC 32119985 VBIEscCol129921_2402 # PIR A65003 B27835 # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HISM_ECOLI Histidine transport system permease protein HisM # RefSeq NP_416810 NC_000913.3 # RefSeq WP_000569958 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION HISM_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00441, ECO 0000269|PubMed 15919996}. # SUBUNIT The complex is composed of two ATP-binding proteins (HisP), two transmembrane proteins (HisM and HisQ) and a solute- binding protein (HisJ or ArgT). {ECO 0000250}. # SUPFAM SSF161098 SSF161098 # TCDB 3.A.1.3.29 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR01726 HEQRo_perm_3TM # eggNOG COG4160 LUCA # eggNOG ENOG4106YG3 Bacteria BLAST swissprot:HISM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HISM_ECOLI BioCyc ECOL316407:JW2304-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2304-MONOMER BioCyc EcoCyc:HISM-MONOMER http://biocyc.org/getid?id=EcoCyc:HISM-MONOMER COG COG4160 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4160 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/nar/15.20.8568 http://dx.doi.org/10.1093/nar/15.20.8568 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U47027 http://www.ebi.ac.uk/ena/data/view/U47027 EMBL Y00455 http://www.ebi.ac.uk/ena/data/view/Y00455 EchoBASE EB0007 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0007 EcoGene EG10007 http://www.ecogene.org/geneInfo.php?eg_id=EG10007 EnsemblBacteria AAC75367 http://www.ensemblgenomes.org/id/AAC75367 EnsemblBacteria AAC75367 http://www.ensemblgenomes.org/id/AAC75367 EnsemblBacteria BAA16153 http://www.ensemblgenomes.org/id/BAA16153 EnsemblBacteria BAA16153 http://www.ensemblgenomes.org/id/BAA16153 EnsemblBacteria BAA16153 http://www.ensemblgenomes.org/id/BAA16153 EnsemblBacteria b2307 http://www.ensemblgenomes.org/id/b2307 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_process GO:0006865 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 946790 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946790 HOGENOM HOG000267552 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267552&db=HOGENOM6 InParanoid P0AEU3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEU3 InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 InterPro IPR010065 http://www.ebi.ac.uk/interpro/entry/IPR010065 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2304 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2304 KEGG_Gene eco:b2307 http://www.genome.jp/dbget-bin/www_bget?eco:b2307 KEGG_Orthology KO:K10015 http://www.genome.jp/dbget-bin/www_bget?KO:K10015 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA IHEYWKS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IHEYWKS PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:HISM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HISM_ECOLI PSORT-B swissprot:HISM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HISM_ECOLI PSORT2 swissprot:HISM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HISM_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Phobius swissprot:HISM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HISM_ECOLI PhylomeDB P0AEU3 http://phylomedb.org/?seqid=P0AEU3 ProteinModelPortal P0AEU3 http://www.proteinmodelportal.org/query/uniprot/P0AEU3 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3313284 http://www.ncbi.nlm.nih.gov/pubmed/3313284 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416810 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416810 RefSeq WP_000569958 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000569958 STRING 511145.b2307 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2307&targetmode=cogs STRING COG4160 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4160&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.3.29 http://www.tcdb.org/search/result.php?tc=3.A.1.3.29 TIGRFAMs TIGR01726 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01726 UniProtKB HISM_ECOLI http://www.uniprot.org/uniprot/HISM_ECOLI UniProtKB-AC P0AEU3 http://www.uniprot.org/uniprot/P0AEU3 charge swissprot:HISM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HISM_ECOLI eggNOG COG4160 http://eggnogapi.embl.de/nog_data/html/tree/COG4160 eggNOG ENOG4106YG3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106YG3 epestfind swissprot:HISM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HISM_ECOLI garnier swissprot:HISM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HISM_ECOLI helixturnhelix swissprot:HISM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HISM_ECOLI hmoment swissprot:HISM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HISM_ECOLI iep swissprot:HISM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HISM_ECOLI inforesidue swissprot:HISM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HISM_ECOLI octanol swissprot:HISM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HISM_ECOLI pepcoil swissprot:HISM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HISM_ECOLI pepdigest swissprot:HISM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HISM_ECOLI pepinfo swissprot:HISM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HISM_ECOLI pepnet swissprot:HISM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HISM_ECOLI pepstats swissprot:HISM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HISM_ECOLI pepwheel swissprot:HISM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HISM_ECOLI pepwindow swissprot:HISM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HISM_ECOLI sigcleave swissprot:HISM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HISM_ECOLI ## Database ID URL or Descriptions # EcoGene EG11059 usg # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003942 N-acetyl-gamma-glutamyl-phosphate reductase activity; IEA:InterPro. # GO_function GO:0004073 aspartate-semialdehyde dehydrogenase activity; IEA:InterPro. # GO_function GO:0050661 NADP binding; IEA:InterPro. # GO_function GO:0051287 NAD binding; IEA:InterPro. # GO_process GO:0009086 methionine biosynthetic process; IEA:InterPro. # GO_process GO:0009088 threonine biosynthetic process; IEA:InterPro. # GO_process GO:0009089 lysine biosynthetic process via diaminopimelate; IEA:InterPro. # GO_process GO:0009097 isoleucine biosynthetic process; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.720 -; 1. # IntAct P08390 17 # InterPro IPR000534 Semialdehyde_DH_NAD-bd # InterPro IPR012080 Asp_semialdehyde_DH # InterPro IPR012280 Semialdhyde_DH_dimer_dom # InterPro IPR016040 NAD(P)-bd_dom # Organism USG_ECOLI Escherichia coli (strain K12) # PATRIC 32120009 VBIEscCol129921_2414 # PIR A23792 QQECH3 # PIRSF PIRSF000148 ASA_dh # Pfam PF01118 Semialdhyde_dh # Pfam PF02774 Semialdhyde_dhC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName USG_ECOLI USG-1 protein # RefSeq NP_416822 NC_000913.3 # RefSeq WP_001289167 NZ_LN832404.1 # SIMILARITY Belongs to the aspartate-semialdehyde dehydrogenase family. {ECO 0000305}. # SMART SM00859 Semialdhyde_dh # SUPFAM SSF51735 SSF51735 # eggNOG COG0136 LUCA # eggNOG ENOG4105CM3 Bacteria BLAST swissprot:USG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:USG_ECOLI BioCyc ECOL316407:JW2316-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2316-MONOMER BioCyc EcoCyc:EG11059-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11059-MONOMER DIP DIP-11095N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11095N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/nar/13.14.5297 http://dx.doi.org/10.1093/nar/13.14.5297 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M15541 http://www.ebi.ac.uk/ena/data/view/M15541 EMBL M15542 http://www.ebi.ac.uk/ena/data/view/M15542 EMBL M29962 http://www.ebi.ac.uk/ena/data/view/M29962 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X02743 http://www.ebi.ac.uk/ena/data/view/X02743 EchoBASE EB1052 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1052 EcoGene EG11059 http://www.ecogene.org/geneInfo.php?eg_id=EG11059 EnsemblBacteria AAC75379 http://www.ensemblgenomes.org/id/AAC75379 EnsemblBacteria AAC75379 http://www.ensemblgenomes.org/id/AAC75379 EnsemblBacteria BAA16176 http://www.ensemblgenomes.org/id/BAA16176 EnsemblBacteria BAA16176 http://www.ensemblgenomes.org/id/BAA16176 EnsemblBacteria BAA16176 http://www.ensemblgenomes.org/id/BAA16176 EnsemblBacteria b2319 http://www.ensemblgenomes.org/id/b2319 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003942 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003942 GO_function GO:0004073 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004073 GO_function GO:0050661 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050661 GO_function GO:0051287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051287 GO_process GO:0009086 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009086 GO_process GO:0009088 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009088 GO_process GO:0009089 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009089 GO_process GO:0009097 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009097 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 946797 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946797 HOGENOM HOG000013357 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000013357&db=HOGENOM6 InParanoid P08390 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P08390 IntAct P08390 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P08390* InterPro IPR000534 http://www.ebi.ac.uk/interpro/entry/IPR000534 InterPro IPR012080 http://www.ebi.ac.uk/interpro/entry/IPR012080 InterPro IPR012280 http://www.ebi.ac.uk/interpro/entry/IPR012280 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 KEGG_Gene ecj:JW2316 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2316 KEGG_Gene eco:b2319 http://www.genome.jp/dbget-bin/www_bget?eco:b2319 MINT MINT-1222362 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1222362 OMA SCVQSPV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SCVQSPV PSORT swissprot:USG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:USG_ECOLI PSORT-B swissprot:USG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:USG_ECOLI PSORT2 swissprot:USG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:USG_ECOLI Pfam PF01118 http://pfam.xfam.org/family/PF01118 Pfam PF02774 http://pfam.xfam.org/family/PF02774 Phobius swissprot:USG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:USG_ECOLI PhylomeDB P08390 http://phylomedb.org/?seqid=P08390 ProteinModelPortal P08390 http://www.proteinmodelportal.org/query/uniprot/P08390 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2681152 http://www.ncbi.nlm.nih.gov/pubmed/2681152 PubMed 2991861 http://www.ncbi.nlm.nih.gov/pubmed/2991861 PubMed 3029016 http://www.ncbi.nlm.nih.gov/pubmed/3029016 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416822 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416822 RefSeq WP_001289167 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001289167 SMART SM00859 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00859 SMR P08390 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P08390 STRING 511145.b2319 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2319&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB USG_ECOLI http://www.uniprot.org/uniprot/USG_ECOLI UniProtKB-AC P08390 http://www.uniprot.org/uniprot/P08390 charge swissprot:USG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:USG_ECOLI eggNOG COG0136 http://eggnogapi.embl.de/nog_data/html/tree/COG0136 eggNOG ENOG4105CM3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CM3 epestfind swissprot:USG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:USG_ECOLI garnier swissprot:USG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:USG_ECOLI helixturnhelix swissprot:USG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:USG_ECOLI hmoment swissprot:USG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:USG_ECOLI iep swissprot:USG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:USG_ECOLI inforesidue swissprot:USG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:USG_ECOLI octanol swissprot:USG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:USG_ECOLI pepcoil swissprot:USG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:USG_ECOLI pepdigest swissprot:USG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:USG_ECOLI pepinfo swissprot:USG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:USG_ECOLI pepnet swissprot:USG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:USG_ECOLI pepstats swissprot:USG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:USG_ECOLI pepwheel swissprot:USG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:USG_ECOLI pepwindow swissprot:USG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:USG_ECOLI sigcleave swissprot:USG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:USG_ECOLI ## Database ID URL or Descriptions # EcoGene EG40009 insI1 # FUNCTION INSI1_ECOLI Required for the transposition of the insertion element. {ECO 0000305}. # GO_component GO:0032993 protein-DNA complex; IDA:EcoCyc. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_function GO:0032135 DNA insertion or deletion binding; IDA:EcoCyc. # GO_function GO:0043565 sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0006313 transposition, DNA-mediated; IDA:EcoCyc. # GO_process GO:0015074 DNA integration; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 3.30.420.10 -; 1. # InterPro IPR001584 Integrase_cat-core # InterPro IPR001598 Transposase_IS30_CS # InterPro IPR012337 RNaseH-like_dom # InterPro IPR025246 IS30-like_HTH # Organism INSI1_ECOLI Escherichia coli (strain K12) # PATRIC 32115631 VBIEscCol129921_0259 # PROSITE PS01043 TRANSPOSASE_IS30 # PROSITE PS50994 INTEGRASE # Pfam PF00665 rve # Pfam PF13936 HTH_38 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSI1_ECOLI Transposase InsI for insertion sequence element IS30A # RefSeq NP_414790 NC_000913.3 # RefSeq WP_001254938 NZ_LN832404.1 # SIMILARITY Belongs to the transposase IS30 family. {ECO 0000305}. # SIMILARITY Contains 1 integrase catalytic domain. {ECO:0000255|PROSITE-ProRule PRU00457}. # SUPFAM SSF53098 SSF53098 # eggNOG COG2826 LUCA # eggNOG ENOG4105F9F Bacteria BLAST swissprot:INSI1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSI1_ECOLI BioCyc EcoCyc:G6131-MONOMER http://biocyc.org/getid?id=EcoCyc:G6131-MONOMER BioCyc MetaCyc:G6131-MONOMER http://biocyc.org/getid?id=MetaCyc:G6131-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EchoBASE EB4703 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4703 EcoGene EG40009 http://www.ecogene.org/geneInfo.php?eg_id=EG40009 EnsemblBacteria AAC73359 http://www.ensemblgenomes.org/id/AAC73359 EnsemblBacteria AAC73359 http://www.ensemblgenomes.org/id/AAC73359 EnsemblBacteria BAE76048 http://www.ensemblgenomes.org/id/BAE76048 EnsemblBacteria BAE76048 http://www.ensemblgenomes.org/id/BAE76048 EnsemblBacteria BAE76048 http://www.ensemblgenomes.org/id/BAE76048 EnsemblBacteria b0256 http://www.ensemblgenomes.org/id/b0256 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0032993 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032993 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_function GO:0032135 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032135 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GO_process GO:0015074 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015074 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 3.30.420.10 http://www.cathdb.info/version/latest/superfamily/3.30.420.10 GeneID 949005 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949005 HOGENOM HOG000114767 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000114767&db=HOGENOM6 InParanoid P0CF88 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CF88 InterPro IPR001584 http://www.ebi.ac.uk/interpro/entry/IPR001584 InterPro IPR001598 http://www.ebi.ac.uk/interpro/entry/IPR001598 InterPro IPR012337 http://www.ebi.ac.uk/interpro/entry/IPR012337 InterPro IPR025246 http://www.ebi.ac.uk/interpro/entry/IPR025246 KEGG_Gene ecj:JW0246 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0246 KEGG_Gene eco:b0256 http://www.genome.jp/dbget-bin/www_bget?eco:b0256 PROSITE PS01043 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01043 PROSITE PS50994 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50994 PSORT swissprot:INSI1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSI1_ECOLI PSORT-B swissprot:INSI1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSI1_ECOLI PSORT2 swissprot:INSI1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSI1_ECOLI Pfam PF00665 http://pfam.xfam.org/family/PF00665 Pfam PF13936 http://pfam.xfam.org/family/PF13936 Phobius swissprot:INSI1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSI1_ECOLI ProteinModelPortal P0CF88 http://www.proteinmodelportal.org/query/uniprot/P0CF88 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414790 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414790 RefSeq WP_001254938 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001254938 STRING 511145.b0256 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0256&targetmode=cogs SUPFAM SSF53098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098 UniProtKB INSI1_ECOLI http://www.uniprot.org/uniprot/INSI1_ECOLI UniProtKB-AC P0CF88 http://www.uniprot.org/uniprot/P0CF88 charge swissprot:INSI1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSI1_ECOLI eggNOG COG2826 http://eggnogapi.embl.de/nog_data/html/tree/COG2826 eggNOG ENOG4105F9F http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F9F epestfind swissprot:INSI1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSI1_ECOLI garnier swissprot:INSI1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSI1_ECOLI helixturnhelix swissprot:INSI1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSI1_ECOLI hmoment swissprot:INSI1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSI1_ECOLI iep swissprot:INSI1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSI1_ECOLI inforesidue swissprot:INSI1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSI1_ECOLI octanol swissprot:INSI1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSI1_ECOLI pepcoil swissprot:INSI1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSI1_ECOLI pepdigest swissprot:INSI1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSI1_ECOLI pepinfo swissprot:INSI1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSI1_ECOLI pepnet swissprot:INSI1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSI1_ECOLI pepstats swissprot:INSI1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSI1_ECOLI pepwheel swissprot:INSI1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSI1_ECOLI pepwindow swissprot:INSI1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSI1_ECOLI sigcleave swissprot:INSI1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSI1_ECOLI ## Database ID URL or Descriptions # EcoGene EG14394 yncL # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # INDUCTION YNCL_ECOLI Expressed during stationary phase (PubMed 19121005), in minimal glucose or glycerol medium and at 45 degrees Celsius (PubMed 19734316) (at protein level). {ECO 0000269|PubMed 19121005, ECO 0000269|PubMed 19734316}. # Organism YNCL_ECOLI Escherichia coli (strain K12) # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNCL_ECOLI Uncharacterized protein YncL # RefSeq YP_001165318 NC_000913.3 # SUBCELLULAR LOCATION YNCL_ECOLI Cell inner membrane {ECO 0000305|PubMed 19121005, ECO 0000305|PubMed 21778229}; Single-pass membrane protein {ECO 0000269|PubMed 19121005, ECO 0000269|PubMed 21778229}. BLAST swissprot:YNCL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNCL_ECOLI BioCyc EcoCyc:MONOMER0-761 http://biocyc.org/getid?id=EcoCyc:MONOMER0-761 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M111.245696 http://dx.doi.org/10.1074/jbc.M111.245696 DOI 10.1111/j.1365-2958.2008.06495.x http://dx.doi.org/10.1111/j.1365-2958.2008.06495.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00872-09 http://dx.doi.org/10.1128/JB.00872-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14394 http://www.ecogene.org/geneInfo.php?eg_id=EG14394 EnsemblBacteria ABP93444 http://www.ensemblgenomes.org/id/ABP93444 EnsemblBacteria ABP93444 http://www.ensemblgenomes.org/id/ABP93444 EnsemblBacteria b4598 http://www.ensemblgenomes.org/id/b4598 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 5061503 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5061503 KEGG_Gene eco:b4598 http://www.genome.jp/dbget-bin/www_bget?eco:b4598 PSORT swissprot:YNCL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNCL_ECOLI PSORT-B swissprot:YNCL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNCL_ECOLI PSORT2 swissprot:YNCL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNCL_ECOLI Phobius swissprot:YNCL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNCL_ECOLI ProteinModelPortal A5A615 http://www.proteinmodelportal.org/query/uniprot/A5A615 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19121005 http://www.ncbi.nlm.nih.gov/pubmed/19121005 PubMed 19734316 http://www.ncbi.nlm.nih.gov/pubmed/19734316 PubMed 21778229 http://www.ncbi.nlm.nih.gov/pubmed/21778229 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq YP_001165318 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001165318 STRING 511145.b4598 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4598&targetmode=cogs UniProtKB YNCL_ECOLI http://www.uniprot.org/uniprot/YNCL_ECOLI UniProtKB-AC A5A615 http://www.uniprot.org/uniprot/A5A615 charge swissprot:YNCL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNCL_ECOLI epestfind swissprot:YNCL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNCL_ECOLI garnier swissprot:YNCL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNCL_ECOLI helixturnhelix swissprot:YNCL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNCL_ECOLI hmoment swissprot:YNCL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNCL_ECOLI iep swissprot:YNCL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNCL_ECOLI inforesidue swissprot:YNCL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNCL_ECOLI octanol swissprot:YNCL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNCL_ECOLI pepcoil swissprot:YNCL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNCL_ECOLI pepdigest swissprot:YNCL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNCL_ECOLI pepinfo swissprot:YNCL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNCL_ECOLI pepnet swissprot:YNCL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNCL_ECOLI pepstats swissprot:YNCL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNCL_ECOLI pepwheel swissprot:YNCL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNCL_ECOLI pepwindow swissprot:YNCL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNCL_ECOLI sigcleave swissprot:YNCL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNCL_ECOLI ## Database ID URL or Descriptions # BioGrid 4261988 145 # DISRUPTION PHENOTYPE Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain. {ECO:0000269|PubMed 20345943}. # EcoGene EG12775 yraJ # FUNCTION YRAJ_ECOLI Part of the yraHIJK fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim operon. Probably involved in the export and assembly of fimbrial subunits across the outer membrane. {ECO 0000269|PubMed 20345943}. # GO_component GO:0009279 cell outer membrane; IBA:GO_Central. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015473 fimbrial usher porin activity; IBA:GO_Central. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0009297 pilus assembly; IBA:GO_Central. # GO_process GO:0043711 pilus organization; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0022607 cellular component assembly # INDUCTION Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression. {ECO:0000269|PubMed 20345943}. # InterPro IPR000015 Fimb_usher # InterPro IPR018030 Fimbrial_membr_usher_CS # InterPro IPR025885 PapC_N # InterPro IPR025949 PapC-like_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02000 Transporters # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko05133 Pertussis # MISCELLANEOUS The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed. {ECO:0000305|PubMed 20345943}. # Organism YRAJ_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30451 PTHR30451 # PATRIC 32121706 VBIEscCol129921_3239 # PIR D65104 D65104 # PROSITE PS01151 FIMBRIAL_USHER # Pfam PF00577 Usher # Pfam PF13953 PapC_C # Pfam PF13954 PapC_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YRAJ_ECOLI Outer membrane usher protein YraJ # RefSeq NP_417613 NC_000913.3 # RefSeq WP_001355538 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA57947.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the fimbrial export usher family. {ECO 0000305}. # SUBCELLULAR LOCATION YRAJ_ECOLI Cell outer membrane {ECO 0000250}; Multi- pass membrane protein {ECO 0000250}. # TCDB 1.B.11.3 the outer membrane fimbrial usher porin (fup) family # eggNOG COG3188 LUCA # eggNOG ENOG4105CW0 Bacteria BLAST swissprot:YRAJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YRAJ_ECOLI BioCyc ECOL316407:JW3113-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3113-MONOMER BioCyc EcoCyc:G7639-MONOMER http://biocyc.org/getid?id=EcoCyc:G7639-MONOMER COG COG3188 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3188 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1462-2920.2010.02202.x http://dx.doi.org/10.1111/j.1462-2920.2010.02202.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2628 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2628 EcoGene EG12775 http://www.ecogene.org/geneInfo.php?eg_id=EG12775 EnsemblBacteria AAC76178 http://www.ensemblgenomes.org/id/AAC76178 EnsemblBacteria AAC76178 http://www.ensemblgenomes.org/id/AAC76178 EnsemblBacteria BAE77190 http://www.ensemblgenomes.org/id/BAE77190 EnsemblBacteria BAE77190 http://www.ensemblgenomes.org/id/BAE77190 EnsemblBacteria BAE77190 http://www.ensemblgenomes.org/id/BAE77190 EnsemblBacteria b3144 http://www.ensemblgenomes.org/id/b3144 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015473 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015473 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0009297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009297 GO_process GO:0043711 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043711 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GeneID 947656 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947656 HOGENOM HOG000111414 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000111414&db=HOGENOM6 InParanoid P42915 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P42915 InterPro IPR000015 http://www.ebi.ac.uk/interpro/entry/IPR000015 InterPro IPR018030 http://www.ebi.ac.uk/interpro/entry/IPR018030 InterPro IPR025885 http://www.ebi.ac.uk/interpro/entry/IPR025885 InterPro IPR025949 http://www.ebi.ac.uk/interpro/entry/IPR025949 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW3113 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3113 KEGG_Gene eco:b3144 http://www.genome.jp/dbget-bin/www_bget?eco:b3144 KEGG_Orthology KO:K07347 http://www.genome.jp/dbget-bin/www_bget?KO:K07347 KEGG_Pathway ko05133 http://www.genome.jp/kegg-bin/show_pathway?ko05133 OMA TAYNENR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TAYNENR PANTHER PTHR30451 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30451 PROSITE PS01151 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01151 PSORT swissprot:YRAJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YRAJ_ECOLI PSORT-B swissprot:YRAJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YRAJ_ECOLI PSORT2 swissprot:YRAJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YRAJ_ECOLI Pfam PF00577 http://pfam.xfam.org/family/PF00577 Pfam PF13953 http://pfam.xfam.org/family/PF13953 Pfam PF13954 http://pfam.xfam.org/family/PF13954 Phobius swissprot:YRAJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YRAJ_ECOLI PhylomeDB P42915 http://phylomedb.org/?seqid=P42915 ProteinModelPortal P42915 http://www.proteinmodelportal.org/query/uniprot/P42915 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20345943 http://www.ncbi.nlm.nih.gov/pubmed/20345943 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417613 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417613 RefSeq WP_001355538 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001355538 SMR P42915 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P42915 STRING 511145.b3144 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3144&targetmode=cogs STRING COG3188 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3188&targetmode=cogs TCDB 1.B.11.3 http://www.tcdb.org/search/result.php?tc=1.B.11.3 UniProtKB YRAJ_ECOLI http://www.uniprot.org/uniprot/YRAJ_ECOLI UniProtKB-AC P42915 http://www.uniprot.org/uniprot/P42915 charge swissprot:YRAJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YRAJ_ECOLI eggNOG COG3188 http://eggnogapi.embl.de/nog_data/html/tree/COG3188 eggNOG ENOG4105CW0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CW0 epestfind swissprot:YRAJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YRAJ_ECOLI garnier swissprot:YRAJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YRAJ_ECOLI helixturnhelix swissprot:YRAJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YRAJ_ECOLI hmoment swissprot:YRAJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YRAJ_ECOLI iep swissprot:YRAJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YRAJ_ECOLI inforesidue swissprot:YRAJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YRAJ_ECOLI octanol swissprot:YRAJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YRAJ_ECOLI pepcoil swissprot:YRAJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YRAJ_ECOLI pepdigest swissprot:YRAJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YRAJ_ECOLI pepinfo swissprot:YRAJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YRAJ_ECOLI pepnet swissprot:YRAJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YRAJ_ECOLI pepstats swissprot:YRAJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YRAJ_ECOLI pepwheel swissprot:YRAJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YRAJ_ECOLI pepwindow swissprot:YRAJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YRAJ_ECOLI sigcleave swissprot:YRAJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YRAJ_ECOLI ## Database ID URL or Descriptions # AltName 2-acyl-GPE acyltransferase {ECO:0000255|HAMAP-Rule MF_01162} # AltName Acyl-ACP synthetase {ECO:0000255|HAMAP-Rule MF_01162} # AltName Acyl-[acyl-carrier-protein]--phospholipid O-acyltransferase {ECO:0000255|HAMAP-Rule MF_01162} # AltName Acyl-[acyl-carrier-protein]--phospholipid O-acyltransferase {ECO:0000255|HAMAP-Rule MF_01162} # AltName Long-chain-fatty-acid--[acyl-carrier-protein] ligase {ECO:0000255|HAMAP-Rule MF_01162} # BRENDA 2.3.1.40 2026 # BioGrid 4259527 15 # CATALYTIC ACTIVITY ATP + a long-chain fatty acid + an [acyl- carrier-protein] = AMP + diphosphate + a long-chain acyl-[acyl- carrier-protein]. {ECO:0000255|HAMAP-Rule MF_01162}. # CATALYTIC ACTIVITY Acyl-[acyl-carrier-protein] + O-(2-acyl-sn- glycero-3-phospho)ethanolamine = [acyl-carrier-protein] + O-(1- beta-acyl-2-acyl-sn-glycero-3-phospho)ethanolamine. {ECO:0000255|HAMAP-Rule MF_01162}. # EcoGene EG11679 aas # FUNCTION AAS_ECOLI Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1. {ECO 0000255|HAMAP-Rule MF_01162, ECO 0000269|PubMed 1649829}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IDA:EcoliWiki. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0008779 acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity; IDA:EcoliWiki. # GO_function GO:0008922 long-chain fatty acid [acyl-carrier-protein] ligase activity; IDA:EcoliWiki. # GO_process GO:0006631 fatty acid metabolic process; IGI:EcoliWiki. # GO_process GO:0008654 phospholipid biosynthetic process; IGI:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # HAMAP MF_01162 Aas # IntAct P31119 9 # InterPro IPR000873 AMP-dep_Synth/Lig # InterPro IPR002123 Plipid/glycerol_acylTrfase # InterPro IPR020845 AMP-binding_CS # InterPro IPR023775 Aas # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00071 Fatty acid metabolism # KEGG_Pathway ko00564 Glycerophospholipid metabolism # Organism AAS_ECOLI Escherichia coli (strain K12) # PATRIC 32121090 VBIEscCol129921_2934 # PIR E65066 E65066 # PROSITE PS00455 AMP_BINDING # Pfam PF00501 AMP-binding # Pfam PF01553 Acyltransferase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 2-acylglycerophosphoethanolamine acyltransferase {ECO:0000255|HAMAP-Rule MF_01162} # RecName Acyl-[acyl-carrier-protein] synthetase {ECO:0000255|HAMAP-Rule MF_01162} # RecName Bifunctional protein Aas {ECO:0000255|HAMAP-Rule MF_01162} # RecName Bifunctional protein Aas {ECO:0000255|HAMAP-Rule MF_01162} # RefSeq NP_417313 NC_000913.3 # RefSeq WP_000899054 NZ_LN832404.1 # SIMILARITY In the C-terminal section; belongs to the ATP- dependent AMP-binding enzyme family. {ECO:0000255|HAMAP- Rule MF_01162}. # SIMILARITY In the N-terminal section; belongs to the 2-acyl-GPE acetyltransferase family. {ECO:0000255|HAMAP-Rule MF_01162}. # SMART SM00563 PlsC # SUBCELLULAR LOCATION AAS_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 4.C.1.1.16 the proposed fatty acid transporter (fat) family # eggNOG COG0204 LUCA # eggNOG COG0318 LUCA # eggNOG ENOG4105CEY Bacteria BLAST swissprot:AAS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AAS_ECOLI BioCyc ECOL316407:JW2804-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2804-MONOMER BioCyc EcoCyc:AAS-MONOMER http://biocyc.org/getid?id=EcoCyc:AAS-MONOMER BioCyc MetaCyc:AAS-MONOMER http://biocyc.org/getid?id=MetaCyc:AAS-MONOMER COG COG0204 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0204 COG COG0318 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0318 DIP DIP-9025N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9025N DOI 10.1007/s00239-002-2423-0 http://dx.doi.org/10.1007/s00239-002-2423-0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.40 {ECO:0000255|HAMAP-Rule:MF_01162} http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.40 {ECO:0000255|HAMAP-Rule:MF_01162} EC_number EC:6.2.1.20 {ECO:0000255|HAMAP-Rule:MF_01162} http://www.genome.jp/dbget-bin/www_bget?EC:6.2.1.20 {ECO:0000255|HAMAP-Rule:MF_01162} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL AY625100 http://www.ebi.ac.uk/ena/data/view/AY625100 EMBL L14681 http://www.ebi.ac.uk/ena/data/view/L14681 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 ENZYME 2.3.1.40 {ECO:0000255|HAMAP-Rule:MF_01162} http://enzyme.expasy.org/EC/2.3.1.40 {ECO:0000255|HAMAP-Rule:MF_01162} ENZYME 6.2.1.20 {ECO:0000255|HAMAP-Rule:MF_01162} http://enzyme.expasy.org/EC/6.2.1.20 {ECO:0000255|HAMAP-Rule:MF_01162} EchoBASE EB1630 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1630 EcoGene EG11679 http://www.ecogene.org/geneInfo.php?eg_id=EG11679 EnsemblBacteria AAC75875 http://www.ensemblgenomes.org/id/AAC75875 EnsemblBacteria AAC75875 http://www.ensemblgenomes.org/id/AAC75875 EnsemblBacteria BAE76905 http://www.ensemblgenomes.org/id/BAE76905 EnsemblBacteria BAE76905 http://www.ensemblgenomes.org/id/BAE76905 EnsemblBacteria BAE76905 http://www.ensemblgenomes.org/id/BAE76905 EnsemblBacteria b2836 http://www.ensemblgenomes.org/id/b2836 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008779 GO_function GO:0008922 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008922 GO_process GO:0006631 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006631 GO_process GO:0008654 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008654 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 947315 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947315 HAMAP MF_01162 http://hamap.expasy.org/unirule/MF_01162 HOGENOM HOG000004907 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000004907&db=HOGENOM6 InParanoid P31119 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31119 IntAct P31119 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31119* IntEnz 2.3.1.40 {ECO:0000255|HAMAP-Rule:MF_01162} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.40 {ECO:0000255|HAMAP-Rule:MF_01162} IntEnz 6.2.1.20 {ECO:0000255|HAMAP-Rule:MF_01162} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.2.1.20 {ECO:0000255|HAMAP-Rule:MF_01162} InterPro IPR000873 http://www.ebi.ac.uk/interpro/entry/IPR000873 InterPro IPR002123 http://www.ebi.ac.uk/interpro/entry/IPR002123 InterPro IPR020845 http://www.ebi.ac.uk/interpro/entry/IPR020845 InterPro IPR023775 http://www.ebi.ac.uk/interpro/entry/IPR023775 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2804 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2804 KEGG_Gene eco:b2836 http://www.genome.jp/dbget-bin/www_bget?eco:b2836 KEGG_Orthology KO:K05939 http://www.genome.jp/dbget-bin/www_bget?KO:K05939 KEGG_Pathway ko00071 http://www.genome.jp/kegg-bin/show_pathway?ko00071 KEGG_Pathway ko00564 http://www.genome.jp/kegg-bin/show_pathway?ko00564 KEGG_Reaction rn:R01406 http://www.genome.jp/dbget-bin/www_bget?rn:R01406 KEGG_Reaction rn:R04864 http://www.genome.jp/dbget-bin/www_bget?rn:R04864 MINT MINT-1308806 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1308806 OMA ANWVYLE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ANWVYLE PROSITE PS00455 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00455 PSORT swissprot:AAS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AAS_ECOLI PSORT-B swissprot:AAS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AAS_ECOLI PSORT2 swissprot:AAS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AAS_ECOLI Pfam PF00501 http://pfam.xfam.org/family/PF00501 Pfam PF01553 http://pfam.xfam.org/family/PF01553 Phobius swissprot:AAS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AAS_ECOLI PhylomeDB P31119 http://phylomedb.org/?seqid=P31119 ProteinModelPortal P31119 http://www.proteinmodelportal.org/query/uniprot/P31119 PubMed 12664169 http://www.ncbi.nlm.nih.gov/pubmed/12664169 PubMed 1649829 http://www.ncbi.nlm.nih.gov/pubmed/1649829 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8300626 http://www.ncbi.nlm.nih.gov/pubmed/8300626 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9515909 http://www.ncbi.nlm.nih.gov/pubmed/9515909 RefSeq NP_417313 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417313 RefSeq WP_000899054 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000899054 SMART SM00563 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00563 STRING 511145.b2836 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2836&targetmode=cogs STRING COG0204 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0204&targetmode=cogs STRING COG0318 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0318&targetmode=cogs TCDB 4.C.1.1.16 http://www.tcdb.org/search/result.php?tc=4.C.1.1.16 UniProtKB AAS_ECOLI http://www.uniprot.org/uniprot/AAS_ECOLI UniProtKB-AC P31119 http://www.uniprot.org/uniprot/P31119 charge swissprot:AAS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AAS_ECOLI eggNOG COG0204 http://eggnogapi.embl.de/nog_data/html/tree/COG0204 eggNOG COG0318 http://eggnogapi.embl.de/nog_data/html/tree/COG0318 eggNOG ENOG4105CEY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CEY epestfind swissprot:AAS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AAS_ECOLI garnier swissprot:AAS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AAS_ECOLI helixturnhelix swissprot:AAS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AAS_ECOLI hmoment swissprot:AAS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AAS_ECOLI iep swissprot:AAS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AAS_ECOLI inforesidue swissprot:AAS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AAS_ECOLI octanol swissprot:AAS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AAS_ECOLI pepcoil swissprot:AAS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AAS_ECOLI pepdigest swissprot:AAS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AAS_ECOLI pepinfo swissprot:AAS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AAS_ECOLI pepnet swissprot:AAS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AAS_ECOLI pepstats swissprot:AAS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AAS_ECOLI pepwheel swissprot:AAS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AAS_ECOLI pepwindow swissprot:AAS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AAS_ECOLI sigcleave swissprot:AAS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AAS_ECOLI ## Database ID URL or Descriptions # BioGrid 4259475 4 # EcoGene EG11471 yigM # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR000620 EamA_dom # InterPro IPR004779 CO/AA/NH_transpt # Organism YIGM_ECOLI Escherichia coli (strain K12) # PATRIC 32123155 VBIEscCol129921_3943 # PIR D65187 D65187 # Pfam PF00892 EamA; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIGM_ECOLI Uncharacterized membrane protein YigM # RefSeq NP_418271 NC_000913.3 # RefSeq WP_001196238 NZ_LN832404.1 # SIMILARITY Contains 1 EamA domain. {ECO 0000305}. # SUBCELLULAR LOCATION YIGM_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # TCDB 2.A.7.3.61 the drug/metabolite transporter (dmt) superfamily # TIGRFAMs TIGR00950 2A78 # eggNOG COG0697 LUCA # eggNOG ENOG4105EMK Bacteria BLAST swissprot:YIGM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIGM_ECOLI BioCyc ECOL316407:JW3803-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3803-MONOMER BioCyc EcoCyc:EG11471-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11471-MONOMER BioCyc MetaCyc:EG11471-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11471-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1439 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1439 EcoGene EG11471 http://www.ecogene.org/geneInfo.php?eg_id=EG11471 EnsemblBacteria AAC76830 http://www.ensemblgenomes.org/id/AAC76830 EnsemblBacteria AAC76830 http://www.ensemblgenomes.org/id/AAC76830 EnsemblBacteria BAE77474 http://www.ensemblgenomes.org/id/BAE77474 EnsemblBacteria BAE77474 http://www.ensemblgenomes.org/id/BAE77474 EnsemblBacteria BAE77474 http://www.ensemblgenomes.org/id/BAE77474 EnsemblBacteria b3827 http://www.ensemblgenomes.org/id/b3827 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 948309 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948309 HOGENOM HOG000269445 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000269445&db=HOGENOM6 InParanoid P0ADP5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADP5 InterPro IPR000620 http://www.ebi.ac.uk/interpro/entry/IPR000620 InterPro IPR004779 http://www.ebi.ac.uk/interpro/entry/IPR004779 KEGG_Gene ecj:JW3803 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3803 KEGG_Gene eco:b3827 http://www.genome.jp/dbget-bin/www_bget?eco:b3827 OMA IWNRDVD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IWNRDVD PSORT swissprot:YIGM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIGM_ECOLI PSORT-B swissprot:YIGM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIGM_ECOLI PSORT2 swissprot:YIGM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIGM_ECOLI Pfam PF00892 http://pfam.xfam.org/family/PF00892 Phobius swissprot:YIGM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIGM_ECOLI PhylomeDB P0ADP5 http://phylomedb.org/?seqid=P0ADP5 ProteinModelPortal P0ADP5 http://www.proteinmodelportal.org/query/uniprot/P0ADP5 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418271 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418271 RefSeq WP_001196238 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001196238 STRING 511145.b3827 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3827&targetmode=cogs TCDB 2.A.7.3.61 http://www.tcdb.org/search/result.php?tc=2.A.7.3.61 TIGRFAMs TIGR00950 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00950 UniProtKB YIGM_ECOLI http://www.uniprot.org/uniprot/YIGM_ECOLI UniProtKB-AC P0ADP5 http://www.uniprot.org/uniprot/P0ADP5 charge swissprot:YIGM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIGM_ECOLI eggNOG COG0697 http://eggnogapi.embl.de/nog_data/html/tree/COG0697 eggNOG ENOG4105EMK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EMK epestfind swissprot:YIGM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIGM_ECOLI garnier swissprot:YIGM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIGM_ECOLI helixturnhelix swissprot:YIGM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIGM_ECOLI hmoment swissprot:YIGM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIGM_ECOLI iep swissprot:YIGM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIGM_ECOLI inforesidue swissprot:YIGM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIGM_ECOLI octanol swissprot:YIGM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIGM_ECOLI pepcoil swissprot:YIGM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIGM_ECOLI pepdigest swissprot:YIGM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIGM_ECOLI pepinfo swissprot:YIGM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIGM_ECOLI pepnet swissprot:YIGM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIGM_ECOLI pepstats swissprot:YIGM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIGM_ECOLI pepwheel swissprot:YIGM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIGM_ECOLI pepwindow swissprot:YIGM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIGM_ECOLI sigcleave swissprot:YIGM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIGM_ECOLI ## Database ID URL or Descriptions # EcoGene EG13929 ydgH # Gene3D 3.30.1660.10 -; 3. # IntAct P76177 4 # InterPro IPR010854 DUF1471 # InterPro IPR025539 YdgH # InterPro IPR025543 Dodecin-like # Organism YDGH_ECOLI Escherichia coli (strain K12) # PATRIC 32118510 VBIEscCol129921_1675 # PIR F64916 F64916 # PIRSF PIRSF014774 YdgH # Pfam PF07338 DUF1471; 3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDGH_ECOLI Protein YdgH # RefSeq NP_416121 NC_000913.3 # RefSeq WP_000769303 NZ_LN832404.1 # SIMILARITY To E.coli YjfY. {ECO 0000305}. # SUPFAM SSF159871 SSF159871; 3 # eggNOG ENOG4105C5D Bacteria # eggNOG ENOG410XNQU LUCA BLAST swissprot:YDGH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDGH_ECOLI BioCyc ECOL316407:JW1596-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1596-MONOMER BioCyc EcoCyc:G6860-MONOMER http://biocyc.org/getid?id=EcoCyc:G6860-MONOMER DIP DIP-11716N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11716N DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3688 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3688 EcoGene EG13929 http://www.ecogene.org/geneInfo.php?eg_id=EG13929 EnsemblBacteria AAC74676 http://www.ensemblgenomes.org/id/AAC74676 EnsemblBacteria AAC74676 http://www.ensemblgenomes.org/id/AAC74676 EnsemblBacteria BAE76481 http://www.ensemblgenomes.org/id/BAE76481 EnsemblBacteria BAE76481 http://www.ensemblgenomes.org/id/BAE76481 EnsemblBacteria BAE76481 http://www.ensemblgenomes.org/id/BAE76481 EnsemblBacteria b1604 http://www.ensemblgenomes.org/id/b1604 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.30.1660.10 http://www.cathdb.info/version/latest/superfamily/3.30.1660.10 GeneID 945117 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945117 HOGENOM HOG000120852 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120852&db=HOGENOM6 IntAct P76177 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76177* InterPro IPR010854 http://www.ebi.ac.uk/interpro/entry/IPR010854 InterPro IPR025539 http://www.ebi.ac.uk/interpro/entry/IPR025539 InterPro IPR025543 http://www.ebi.ac.uk/interpro/entry/IPR025543 KEGG_Gene ecj:JW1596 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1596 KEGG_Gene eco:b1604 http://www.genome.jp/dbget-bin/www_bget?eco:b1604 OMA FYIVRQV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FYIVRQV PSORT swissprot:YDGH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDGH_ECOLI PSORT-B swissprot:YDGH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDGH_ECOLI PSORT2 swissprot:YDGH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDGH_ECOLI Pfam PF07338 http://pfam.xfam.org/family/PF07338 Phobius swissprot:YDGH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDGH_ECOLI ProteinModelPortal P76177 http://www.proteinmodelportal.org/query/uniprot/P76177 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416121 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416121 RefSeq WP_000769303 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000769303 SMR P76177 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76177 STRING 511145.b1604 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1604&targetmode=cogs SUPFAM SSF159871 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF159871 UniProtKB YDGH_ECOLI http://www.uniprot.org/uniprot/YDGH_ECOLI UniProtKB-AC P76177 http://www.uniprot.org/uniprot/P76177 charge swissprot:YDGH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDGH_ECOLI eggNOG ENOG4105C5D http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C5D eggNOG ENOG410XNQU http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNQU epestfind swissprot:YDGH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDGH_ECOLI garnier swissprot:YDGH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDGH_ECOLI helixturnhelix swissprot:YDGH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDGH_ECOLI hmoment swissprot:YDGH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDGH_ECOLI iep swissprot:YDGH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDGH_ECOLI inforesidue swissprot:YDGH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDGH_ECOLI octanol swissprot:YDGH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDGH_ECOLI pepcoil swissprot:YDGH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDGH_ECOLI pepdigest swissprot:YDGH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDGH_ECOLI pepinfo swissprot:YDGH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDGH_ECOLI pepnet swissprot:YDGH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDGH_ECOLI pepstats swissprot:YDGH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDGH_ECOLI pepwheel swissprot:YDGH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDGH_ECOLI pepwindow swissprot:YDGH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDGH_ECOLI sigcleave swissprot:YDGH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDGH_ECOLI ## Database ID URL or Descriptions # BioGrid 4261253 425 # CAUTION Was originally (PubMed:2973057) thought to be a protease. However, removal of residues '165-200' of complex member HflC (a ClpP-protease-like motif) does not alter the lysogenization process, and in vitro studies show no evidence of a protease activity for the isolated HflKC complex. {ECO 0000305|PubMed:2973057}. # CDD cd03404 SPFH_HflK # EcoGene EG10436 hflK # FUNCTION HFLK_ECOLI HflC and HflK help govern the stability of phage lambda cII protein, and thereby control the lysogenization frequency of phage lambda. HflKC inhibits the SecY-degrading activity of FtsH, possibly helping quality control of integral membrane proteins. {ECO 0000269|PubMed 8947034}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0071575 integral component of external side of plasma membrane; IDA:EcoCyc. # GO_process GO:0009408 response to heat; IEP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_process GO:0006950 response to stress # IntAct P0ABC7 11 # InterPro IPR001107 Band_7 # InterPro IPR001972 Stomatin_fam # InterPro IPR010201 HflK # InterPro IPR020980 Membrane_HflK_N # KEGG_Brite ko01000 Enzymes # MISCELLANEOUS HFLK_ECOLI Integration of this protein into the membrane depends on SecA, SecY and SecD but not on SecB or FtsY. HflK is unstable in the absence of HflC. # Organism HFLK_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10264 PTHR10264 # PANTHER PTHR10264:SF51 PTHR10264:SF51 # PATRIC 32123921 VBIEscCol129921_4305 # PIR B43653 B43653 # PRINTS PR00721 STOMATIN # Pfam PF01145 Band_7 # Pfam PF12221 HflK_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HFLK_ECOLI Modulator of FtsH protease HflK # RefSeq NP_418595 NC_000913.3 # RefSeq WP_000312488 NZ_LN832404.1 # SIMILARITY Belongs to the band 7/mec-2 family. HflK subfamily. {ECO 0000305}. # SMART SM00244 PHB # SUBCELLULAR LOCATION HFLK_ECOLI Cell inner membrane {ECO 0000269|PubMed 8947034}; Single-pass type II membrane protein {ECO 0000269|PubMed 8947034}. # SUBUNIT HFLK_ECOLI HflC and HflK interact to form a complex, originally called HflA, now called HflKC. HflKC interacts with FtsH; complex formation is stimulated by ATP, and with YccA. {ECO 0000269|PubMed 2973057, ECO 0000269|PubMed 8947034, ECO 0000269|PubMed 9636708}. # SUPFAM SSF117892 SSF117892 # TIGRFAMs TIGR01933 hflK # eggNOG COG0330 LUCA # eggNOG ENOG4107QJR Bacteria BLAST swissprot:HFLK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HFLK_ECOLI BioCyc ECOL316407:JW4132-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4132-MONOMER BioCyc EcoCyc:EG10436-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10436-MONOMER BioCyc MetaCyc:EG10436-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10436-MONOMER COG COG0330 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0330 DIP DIP-47481N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47481N DOI 10.1006/jmbi.1998.1781 http://dx.doi.org/10.1006/jmbi.1998.1781 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.85.21.7882 http://dx.doi.org/10.1073/pnas.85.21.7882 DOI 10.1073/pnas.90.22.10866 http://dx.doi.org/10.1073/pnas.90.22.10866 DOI 10.1073/pnas.94.11.5544 http://dx.doi.org/10.1073/pnas.94.11.5544 DOI 10.1074/jbc.273.45.29770 http://dx.doi.org/10.1074/jbc.273.45.29770 DOI 10.1093/jb/mvp071 http://dx.doi.org/10.1093/jb/mvp071 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00005 http://www.ebi.ac.uk/ena/data/view/U00005 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB0431 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0431 EcoGene EG10436 http://www.ecogene.org/geneInfo.php?eg_id=EG10436 EnsemblBacteria AAC77131 http://www.ensemblgenomes.org/id/AAC77131 EnsemblBacteria AAC77131 http://www.ensemblgenomes.org/id/AAC77131 EnsemblBacteria BAE78175 http://www.ensemblgenomes.org/id/BAE78175 EnsemblBacteria BAE78175 http://www.ensemblgenomes.org/id/BAE78175 EnsemblBacteria BAE78175 http://www.ensemblgenomes.org/id/BAE78175 EnsemblBacteria b4174 http://www.ensemblgenomes.org/id/b4174 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0071575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071575 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 948698 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948698 HOGENOM HOG000260983 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260983&db=HOGENOM6 InParanoid P0ABC7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABC7 IntAct P0ABC7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABC7* InterPro IPR001107 http://www.ebi.ac.uk/interpro/entry/IPR001107 InterPro IPR001972 http://www.ebi.ac.uk/interpro/entry/IPR001972 InterPro IPR010201 http://www.ebi.ac.uk/interpro/entry/IPR010201 InterPro IPR020980 http://www.ebi.ac.uk/interpro/entry/IPR020980 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4132 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4132 KEGG_Gene eco:b4174 http://www.genome.jp/dbget-bin/www_bget?eco:b4174 KEGG_Orthology KO:K04088 http://www.genome.jp/dbget-bin/www_bget?KO:K04088 MINT MINT-1271770 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1271770 OMA WNEPGGN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WNEPGGN PANTHER PTHR10264 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10264 PANTHER PTHR10264:SF51 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10264:SF51 PRINTS PR00721 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00721 PSORT swissprot:HFLK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HFLK_ECOLI PSORT-B swissprot:HFLK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HFLK_ECOLI PSORT2 swissprot:HFLK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HFLK_ECOLI Pfam PF01145 http://pfam.xfam.org/family/PF01145 Pfam PF12221 http://pfam.xfam.org/family/PF12221 Phobius swissprot:HFLK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HFLK_ECOLI PhylomeDB P0ABC7 http://phylomedb.org/?seqid=P0ABC7 ProteinModelPortal P0ABC7 http://www.proteinmodelportal.org/query/uniprot/P0ABC7 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19454621 http://www.ncbi.nlm.nih.gov/pubmed/19454621 PubMed 2973057 http://www.ncbi.nlm.nih.gov/pubmed/2973057 PubMed 3040675 http://www.ncbi.nlm.nih.gov/pubmed/3040675 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8248183 http://www.ncbi.nlm.nih.gov/pubmed/8248183 PubMed 8947034 http://www.ncbi.nlm.nih.gov/pubmed/8947034 PubMed 9159109 http://www.ncbi.nlm.nih.gov/pubmed/9159109 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9636708 http://www.ncbi.nlm.nih.gov/pubmed/9636708 PubMed 9792691 http://www.ncbi.nlm.nih.gov/pubmed/9792691 RefSeq NP_418595 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418595 RefSeq WP_000312488 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000312488 SMART SM00244 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00244 SMR P0ABC7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABC7 STRING 511145.b4174 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4174&targetmode=cogs STRING COG0330 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0330&targetmode=cogs SUPFAM SSF117892 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF117892 TIGRFAMs TIGR01933 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01933 UniProtKB HFLK_ECOLI http://www.uniprot.org/uniprot/HFLK_ECOLI UniProtKB-AC P0ABC7 http://www.uniprot.org/uniprot/P0ABC7 charge swissprot:HFLK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HFLK_ECOLI eggNOG COG0330 http://eggnogapi.embl.de/nog_data/html/tree/COG0330 eggNOG ENOG4107QJR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QJR epestfind swissprot:HFLK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HFLK_ECOLI garnier swissprot:HFLK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HFLK_ECOLI helixturnhelix swissprot:HFLK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HFLK_ECOLI hmoment swissprot:HFLK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HFLK_ECOLI iep swissprot:HFLK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HFLK_ECOLI inforesidue swissprot:HFLK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HFLK_ECOLI octanol swissprot:HFLK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HFLK_ECOLI pepcoil swissprot:HFLK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HFLK_ECOLI pepdigest swissprot:HFLK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HFLK_ECOLI pepinfo swissprot:HFLK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HFLK_ECOLI pepnet swissprot:HFLK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HFLK_ECOLI pepstats swissprot:HFLK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HFLK_ECOLI pepwheel swissprot:HFLK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HFLK_ECOLI pepwindow swissprot:HFLK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HFLK_ECOLI sigcleave swissprot:HFLK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HFLK_ECOLI ## Database ID URL or Descriptions # CAUTION TraG is not responsible for the N-terminal acetylation of F pilin as stated by some authors. {ECO 0000305}. # FUNCTION TRAG1_ECOLI Plays a crucial role in donor-recipient cell interactions. Required for two stages of the conjugation process pilus biosynthesis and mating aggregate stabilization. May interact with TraN. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0000746 conjugation; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0008150 biological_process # InterPro IPR012931 TraG_N # Organism TRAG1_ECOLI Escherichia coli (strain K12) # PIR S20480 S20480 # PTM TRAG1_ECOLI TraG* probably arises from the post-translational cleavage of TraG. # Pfam PF07916 TraG_N # RecName TRAG1_ECOLI Protein TraG # RecName TRAG1_ECOLI Protein TraG # RecName TRAG1_ECOLI Protein TraG* # RefSeq NP_061478 NC_002483.1 # RefSeq WP_001007055 NZ_CP014273.1 # SUBCELLULAR LOCATION TRAG1_ECOLI Cell inner membrane; Multi-pass membrane protein. BLAST swissprot:TRAG1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRAG1_ECOLI DOI 10.1007/BF00299147 http://dx.doi.org/10.1007/BF00299147 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL M59763 http://www.ebi.ac.uk/ena/data/view/M59763 EMBL U01159 http://www.ebi.ac.uk/ena/data/view/U01159 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0000746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000746 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 1263567 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263567 InterPro IPR012931 http://www.ebi.ac.uk/interpro/entry/IPR012931 OMA TQNSIRG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TQNSIRG PSORT swissprot:TRAG1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRAG1_ECOLI PSORT-B swissprot:TRAG1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRAG1_ECOLI PSORT2 swissprot:TRAG1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRAG1_ECOLI Pfam PF07916 http://pfam.xfam.org/family/PF07916 Phobius swissprot:TRAG1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRAG1_ECOLI ProteinModelPortal P33790 http://www.proteinmodelportal.org/query/uniprot/P33790 PubMed 1348105 http://www.ncbi.nlm.nih.gov/pubmed/1348105 PubMed 7915817 http://www.ncbi.nlm.nih.gov/pubmed/7915817 RefSeq NP_061478 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061478 RefSeq WP_001007055 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001007055 UniProtKB TRAG1_ECOLI http://www.uniprot.org/uniprot/TRAG1_ECOLI UniProtKB-AC P33790 http://www.uniprot.org/uniprot/P33790 charge swissprot:TRAG1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRAG1_ECOLI epestfind swissprot:TRAG1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRAG1_ECOLI garnier swissprot:TRAG1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRAG1_ECOLI helixturnhelix swissprot:TRAG1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRAG1_ECOLI hmoment swissprot:TRAG1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRAG1_ECOLI iep swissprot:TRAG1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRAG1_ECOLI inforesidue swissprot:TRAG1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRAG1_ECOLI octanol swissprot:TRAG1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRAG1_ECOLI pepcoil swissprot:TRAG1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRAG1_ECOLI pepdigest swissprot:TRAG1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRAG1_ECOLI pepinfo swissprot:TRAG1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRAG1_ECOLI pepnet swissprot:TRAG1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRAG1_ECOLI pepstats swissprot:TRAG1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRAG1_ECOLI pepwheel swissprot:TRAG1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRAG1_ECOLI pepwindow swissprot:TRAG1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRAG1_ECOLI sigcleave swissprot:TRAG1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRAG1_ECOLI ## Database ID URL or Descriptions # BioGrid 4261727 22 # CDD cd01879 FeoB # DOMAIN FEOB_ECOLI Contains a guanine-nucleotide-specific nucleotide-binding site that shows slow GTP hydrolysis. # EcoGene EG12102 feoB # FUNCTION FEOB_ECOLI GTP-driven Fe(2+) uptake system. {ECO 0000269|PubMed 12446835, ECO 0000269|PubMed 8407793}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0003924 GTPase activity; IBA:GO_Central. # GO_function GO:0005525 GTP binding; IMP:EcoCyc. # GO_function GO:0015093 ferrous iron transmembrane transporter activity; IMP:EcoCyc. # GO_function GO:0042802 identical protein binding; IPI:IntAct. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0015684 ferrous iron transport; IMP:EcoCyc. # GO_process GO:0055072 iron ion homeostasis; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003924 GTPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # GOslim_process GO:0006950 response to stress # GOslim_process GO:0042592 homeostatic process # Gene3D 3.40.50.300 -; 1. # INDUCTION Iron uptake is repressed by the global regulator Fur. Induced by hydroxyurea (PubMed:20005847). {ECO 0000269|PubMed:20005847}. # INTERACTION FEOB_ECOLI Self; NbExp=5; IntAct=EBI-7131497, EBI-7131497; # InterPro IPR003373 Fe2_transport_prot-B # InterPro IPR011640 Fe2_transport_prot_B_C # InterPro IPR011642 Gate_dom # InterPro IPR027417 P-loop_NTPase # InterPro IPR030389 G_FEOB_dom # KEGG_Brite ko02000 Transporters # MISCELLANEOUS FEOB_ECOLI Binding of GTP is required for an efficient Fe(2+) uptake. # Organism FEOB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11649:SF37 PTHR11649:SF37; 3 # PATRIC 32122254 VBIEscCol129921_3504 # PDB 3HYR X-ray; 2.20 A; A/B/C=1-270 # PDB 3HYT X-ray; 2.74 A; A/B/C=1-270 # PDB 3I8S X-ray; 1.80 A; A/B/C=1-274 # PDB 3I8X X-ray; 2.25 A; A/B/C=1-274 # PDB 3I92 X-ray; 3.00 A; A/B/C=1-274 # PDB 4Q00 X-ray; 2.10 A; A/B/C=1-261 # PDB 4Q5I X-ray; 2.80 A; A/B/C/D/E/F=1-270 # PDB 4R98 X-ray; 2.22 A; A/B=1-270 # PIR A36932 A36932 # PROSITE PS51711 G_FEOB # Pfam PF02421 FeoB_N # Pfam PF07664 FeoB_C # Pfam PF07670 Gate; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FEOB_ECOLI Ferrous iron transport protein B # RefSeq NP_417868 NC_000913.3 # RefSeq WP_000737039 NZ_LN832404.1 # SIMILARITY Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. FeoB GTPase (TC 9.A.8) family. {ECO:0000255|PROSITE-ProRule PRU01048}. # SIMILARITY Contains 1 FeoB-type G (guanine nucleotide-binding) domain. {ECO:0000255|PROSITE-ProRule PRU01048}. # SUBCELLULAR LOCATION FEOB_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF52540 SSF52540 # TCDB 9.A.8.1 the ferrous iron uptake (feob) family # TIGRFAMs TIGR00437 feoB # eggNOG COG0370 LUCA # eggNOG ENOG4105CE1 Bacteria BLAST swissprot:FEOB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FEOB_ECOLI BioCyc ECOL316407:JW3372-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3372-MONOMER BioCyc EcoCyc:FEOB-MONOMER http://biocyc.org/getid?id=EcoCyc:FEOB-MONOMER BioCyc MetaCyc:FEOB-MONOMER http://biocyc.org/getid?id=MetaCyc:FEOB-MONOMER COG COG0370 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0370 DIP DIP-9591N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9591N DOI 10.1007/s00239-002-2423-0 http://dx.doi.org/10.1007/s00239-002-2423-0 DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.242338299 http://dx.doi.org/10.1073/pnas.242338299 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL AY625107 http://www.ebi.ac.uk/ena/data/view/AY625107 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X71063 http://www.ebi.ac.uk/ena/data/view/X71063 EchoBASE EB2026 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2026 EcoGene EG12102 http://www.ecogene.org/geneInfo.php?eg_id=EG12102 EnsemblBacteria AAC76434 http://www.ensemblgenomes.org/id/AAC76434 EnsemblBacteria AAC76434 http://www.ensemblgenomes.org/id/AAC76434 EnsemblBacteria BAE77882 http://www.ensemblgenomes.org/id/BAE77882 EnsemblBacteria BAE77882 http://www.ensemblgenomes.org/id/BAE77882 EnsemblBacteria BAE77882 http://www.ensemblgenomes.org/id/BAE77882 EnsemblBacteria b3409 http://www.ensemblgenomes.org/id/b3409 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_function GO:0015093 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015093 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0015684 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015684 GO_process GO:0055072 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055072 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947919 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947919 HOGENOM HOG000054023 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000054023&db=HOGENOM6 InParanoid P33650 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33650 InterPro IPR003373 http://www.ebi.ac.uk/interpro/entry/IPR003373 InterPro IPR011640 http://www.ebi.ac.uk/interpro/entry/IPR011640 InterPro IPR011642 http://www.ebi.ac.uk/interpro/entry/IPR011642 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR030389 http://www.ebi.ac.uk/interpro/entry/IPR030389 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3372 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3372 KEGG_Gene eco:b3409 http://www.genome.jp/dbget-bin/www_bget?eco:b3409 KEGG_Orthology KO:K04759 http://www.genome.jp/dbget-bin/www_bget?KO:K04759 MINT MINT-7914741 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-7914741 OMA LVMEMPD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LVMEMPD PANTHER PTHR11649:SF37 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11649:SF37 PDB 3HYR http://www.ebi.ac.uk/pdbe-srv/view/entry/3HYR PDB 3HYT http://www.ebi.ac.uk/pdbe-srv/view/entry/3HYT PDB 3I8S http://www.ebi.ac.uk/pdbe-srv/view/entry/3I8S PDB 3I8X http://www.ebi.ac.uk/pdbe-srv/view/entry/3I8X PDB 3I92 http://www.ebi.ac.uk/pdbe-srv/view/entry/3I92 PDB 4Q00 http://www.ebi.ac.uk/pdbe-srv/view/entry/4Q00 PDB 4Q5I http://www.ebi.ac.uk/pdbe-srv/view/entry/4Q5I PDB 4R98 http://www.ebi.ac.uk/pdbe-srv/view/entry/4R98 PDBsum 3HYR http://www.ebi.ac.uk/pdbsum/3HYR PDBsum 3HYT http://www.ebi.ac.uk/pdbsum/3HYT PDBsum 3I8S http://www.ebi.ac.uk/pdbsum/3I8S PDBsum 3I8X http://www.ebi.ac.uk/pdbsum/3I8X PDBsum 3I92 http://www.ebi.ac.uk/pdbsum/3I92 PDBsum 4Q00 http://www.ebi.ac.uk/pdbsum/4Q00 PDBsum 4Q5I http://www.ebi.ac.uk/pdbsum/4Q5I PDBsum 4R98 http://www.ebi.ac.uk/pdbsum/4R98 PROSITE PS51711 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51711 PSORT swissprot:FEOB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FEOB_ECOLI PSORT-B swissprot:FEOB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FEOB_ECOLI PSORT2 swissprot:FEOB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FEOB_ECOLI Pfam PF02421 http://pfam.xfam.org/family/PF02421 Pfam PF07664 http://pfam.xfam.org/family/PF07664 Pfam PF07670 http://pfam.xfam.org/family/PF07670 Phobius swissprot:FEOB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FEOB_ECOLI PhylomeDB P33650 http://phylomedb.org/?seqid=P33650 ProteinModelPortal P33650 http://www.proteinmodelportal.org/query/uniprot/P33650 PubMed 12446835 http://www.ncbi.nlm.nih.gov/pubmed/12446835 PubMed 12664169 http://www.ncbi.nlm.nih.gov/pubmed/12664169 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 8407793 http://www.ncbi.nlm.nih.gov/pubmed/8407793 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417868 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417868 RefSeq WP_000737039 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000737039 SMR P33650 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33650 STRING 511145.b3409 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3409&targetmode=cogs STRING COG0370 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0370&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 9.A.8.1 http://www.tcdb.org/search/result.php?tc=9.A.8.1 TIGRFAMs TIGR00437 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00437 UniProtKB FEOB_ECOLI http://www.uniprot.org/uniprot/FEOB_ECOLI UniProtKB-AC P33650 http://www.uniprot.org/uniprot/P33650 charge swissprot:FEOB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FEOB_ECOLI eggNOG COG0370 http://eggnogapi.embl.de/nog_data/html/tree/COG0370 eggNOG ENOG4105CE1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CE1 epestfind swissprot:FEOB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FEOB_ECOLI garnier swissprot:FEOB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FEOB_ECOLI helixturnhelix swissprot:FEOB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FEOB_ECOLI hmoment swissprot:FEOB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FEOB_ECOLI iep swissprot:FEOB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FEOB_ECOLI inforesidue swissprot:FEOB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FEOB_ECOLI octanol swissprot:FEOB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FEOB_ECOLI pepcoil swissprot:FEOB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FEOB_ECOLI pepdigest swissprot:FEOB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FEOB_ECOLI pepinfo swissprot:FEOB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FEOB_ECOLI pepnet swissprot:FEOB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FEOB_ECOLI pepstats swissprot:FEOB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FEOB_ECOLI pepwheel swissprot:FEOB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FEOB_ECOLI pepwindow swissprot:FEOB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FEOB_ECOLI sigcleave swissprot:FEOB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FEOB_ECOLI ## Database ID URL or Descriptions # BioGrid 4262156 331 # CDD cd06174 MFS # EcoGene EG12249 yhjE # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0022857 transmembrane transporter activity; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # InterPro IPR004736 Cit_H_symport # InterPro IPR005828 MFS_sugar_transport-like # InterPro IPR005829 Sugar_transporter_CS # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # Organism YHJE_ECOLI Escherichia coli (strain K12) # PATRIC 32122508 VBIEscCol129921_3632 # PIR S47743 S47743 # PROSITE PS00216 SUGAR_TRANSPORT_1 # PROSITE PS50850 MFS # Pfam PF00083 Sugar_tr # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHJE_ECOLI Inner membrane metabolite transport protein YhjE # RefSeq NP_417980 NC_000913.3 # RefSeq WP_001149003 NZ_LN832404.1 # SIMILARITY Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. {ECO 0000305}. # SUBCELLULAR LOCATION YHJE_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.6.10 the major facilitator superfamily (mfs) # TIGRFAMs TIGR00883 2A0106 # eggNOG ENOG4105CSH Bacteria # eggNOG ENOG410XP7I LUCA BLAST swissprot:YHJE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHJE_ECOLI BioCyc ECOL316407:JW3491-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3491-MONOMER BioCyc EcoCyc:YHJE-MONOMER http://biocyc.org/getid?id=EcoCyc:YHJE-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2160 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2160 EcoGene EG12249 http://www.ecogene.org/geneInfo.php?eg_id=EG12249 EnsemblBacteria AAC76548 http://www.ensemblgenomes.org/id/AAC76548 EnsemblBacteria AAC76548 http://www.ensemblgenomes.org/id/AAC76548 EnsemblBacteria BAE77771 http://www.ensemblgenomes.org/id/BAE77771 EnsemblBacteria BAE77771 http://www.ensemblgenomes.org/id/BAE77771 EnsemblBacteria BAE77771 http://www.ensemblgenomes.org/id/BAE77771 EnsemblBacteria b3523 http://www.ensemblgenomes.org/id/b3523 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GeneID 948032 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948032 HOGENOM HOG000141611 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000141611&db=HOGENOM6 InParanoid P37643 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37643 InterPro IPR004736 http://www.ebi.ac.uk/interpro/entry/IPR004736 InterPro IPR005828 http://www.ebi.ac.uk/interpro/entry/IPR005828 InterPro IPR005829 http://www.ebi.ac.uk/interpro/entry/IPR005829 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Gene ecj:JW3491 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3491 KEGG_Gene eco:b3523 http://www.genome.jp/dbget-bin/www_bget?eco:b3523 OMA STYAQAP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=STYAQAP PROSITE PS00216 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00216 PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:YHJE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHJE_ECOLI PSORT-B swissprot:YHJE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHJE_ECOLI PSORT2 swissprot:YHJE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHJE_ECOLI Pfam PF00083 http://pfam.xfam.org/family/PF00083 Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:YHJE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHJE_ECOLI PhylomeDB P37643 http://phylomedb.org/?seqid=P37643 ProteinModelPortal P37643 http://www.proteinmodelportal.org/query/uniprot/P37643 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417980 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417980 RefSeq WP_001149003 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001149003 STRING 511145.b3523 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3523&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.6.10 http://www.tcdb.org/search/result.php?tc=2.A.1.6.10 TIGRFAMs TIGR00883 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00883 UniProtKB YHJE_ECOLI http://www.uniprot.org/uniprot/YHJE_ECOLI UniProtKB-AC P37643 http://www.uniprot.org/uniprot/P37643 charge swissprot:YHJE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHJE_ECOLI eggNOG ENOG4105CSH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CSH eggNOG ENOG410XP7I http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XP7I epestfind swissprot:YHJE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHJE_ECOLI garnier swissprot:YHJE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHJE_ECOLI helixturnhelix swissprot:YHJE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHJE_ECOLI hmoment swissprot:YHJE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHJE_ECOLI iep swissprot:YHJE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHJE_ECOLI inforesidue swissprot:YHJE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHJE_ECOLI octanol swissprot:YHJE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHJE_ECOLI pepcoil swissprot:YHJE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHJE_ECOLI pepdigest swissprot:YHJE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHJE_ECOLI pepinfo swissprot:YHJE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHJE_ECOLI pepnet swissprot:YHJE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHJE_ECOLI pepstats swissprot:YHJE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHJE_ECOLI pepwheel swissprot:YHJE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHJE_ECOLI pepwindow swissprot:YHJE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHJE_ECOLI sigcleave swissprot:YHJE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHJE_ECOLI ## Database ID URL or Descriptions # BRENDA 2.4.99.B6 2026 # BioGrid 4263304 489 # CAZy GT9 Glycosyltransferase Family 9 # EcoGene EG11189 rfaC # FUNCTION RFAC_ECOLI Heptose transfer to the lipopolysaccharide core. It transfers the innermost heptose to [4'-P](3-deoxy-D-manno- octulosonic acid)2-IVA. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0008713 ADP-heptose-lipopolysaccharide heptosyltransferase activity; IBA:GO_Central. # GO_function GO:0008920 lipopolysaccharide heptosyltransferase activity; IDA:CACAO. # GO_process GO:0009244 lipopolysaccharide core region biosynthetic process; IMP:CACAO. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # IntAct P24173 17 # InterPro IPR002201 Glyco_trans_9 # InterPro IPR011908 LipoPS_heptosylTferase-I # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01003 Glycosyltransferases # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # KEGG_Pathway ko00540 Lipopolysaccharide biosynthesis # Organism RFAC_ECOLI Escherichia coli (strain K12) # PATHWAY RFAC_ECOLI Bacterial outer membrane biogenesis; LPS core biosynthesis. # PATRIC 32122729 VBIEscCol129921_3741 # PDB 2H1H X-ray; 2.40 A; A/B=1-300 # PIR A40619 A40619 # Pfam PF01075 Glyco_transf_9 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RFAC_ECOLI Lipopolysaccharide heptosyltransferase 1 # RefSeq NP_418078 NC_000913.3 # RefSeq WP_001264584 NZ_LN832404.1 # SIMILARITY Belongs to the glycosyltransferase 9 family. {ECO 0000305}. # TIGRFAMs TIGR02193 heptsyl_trn_I # eggNOG COG0859 LUCA # eggNOG ENOG4105D16 Bacteria BLAST swissprot:RFAC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RFAC_ECOLI BioCyc ECOL316407:JW3596-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3596-MONOMER BioCyc EcoCyc:EG11189-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11189-MONOMER BioCyc MetaCyc:EG11189-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11189-MONOMER COG COG0859 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0859 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:2.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M95398 http://www.ebi.ac.uk/ena/data/view/M95398 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X62530 http://www.ebi.ac.uk/ena/data/view/X62530 ENZYME 2.-.-.- http://enzyme.expasy.org/EC/2.-.-.- EchoBASE EB1175 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1175 EcoGene EG11189 http://www.ecogene.org/geneInfo.php?eg_id=EG11189 EnsemblBacteria AAC76645 http://www.ensemblgenomes.org/id/AAC76645 EnsemblBacteria AAC76645 http://www.ensemblgenomes.org/id/AAC76645 EnsemblBacteria BAE77671 http://www.ensemblgenomes.org/id/BAE77671 EnsemblBacteria BAE77671 http://www.ensemblgenomes.org/id/BAE77671 EnsemblBacteria BAE77671 http://www.ensemblgenomes.org/id/BAE77671 EnsemblBacteria b3621 http://www.ensemblgenomes.org/id/b3621 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008713 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008713 GO_function GO:0008920 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008920 GO_process GO:0009244 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009244 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 948136 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948136 HOGENOM HOG000257134 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000257134&db=HOGENOM6 InParanoid P24173 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P24173 IntAct P24173 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P24173* IntEnz 2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2 InterPro IPR002201 http://www.ebi.ac.uk/interpro/entry/IPR002201 InterPro IPR011908 http://www.ebi.ac.uk/interpro/entry/IPR011908 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01003 http://www.genome.jp/dbget-bin/www_bget?ko01003 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Gene ecj:JW3596 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3596 KEGG_Gene eco:b3621 http://www.genome.jp/dbget-bin/www_bget?eco:b3621 KEGG_Orthology KO:K02841 http://www.genome.jp/dbget-bin/www_bget?KO:K02841 KEGG_Pathway ko00540 http://www.genome.jp/kegg-bin/show_pathway?ko00540 OMA EIPAWHP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EIPAWHP PDB 2H1H http://www.ebi.ac.uk/pdbe-srv/view/entry/2H1H PDBsum 2H1H http://www.ebi.ac.uk/pdbsum/2H1H PSORT swissprot:RFAC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RFAC_ECOLI PSORT-B swissprot:RFAC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RFAC_ECOLI PSORT2 swissprot:RFAC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RFAC_ECOLI Pfam PF01075 http://pfam.xfam.org/family/PF01075 Phobius swissprot:RFAC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RFAC_ECOLI PhylomeDB P24173 http://phylomedb.org/?seqid=P24173 ProteinModelPortal P24173 http://www.proteinmodelportal.org/query/uniprot/P24173 PubMed 1624462 http://www.ncbi.nlm.nih.gov/pubmed/1624462 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 8478319 http://www.ncbi.nlm.nih.gov/pubmed/8478319 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418078 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418078 RefSeq WP_001264584 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001264584 SMR P24173 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P24173 STRING 511145.b3621 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3621&targetmode=cogs STRING COG0859 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0859&targetmode=cogs TIGRFAMs TIGR02193 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02193 UniProtKB RFAC_ECOLI http://www.uniprot.org/uniprot/RFAC_ECOLI UniProtKB-AC P24173 http://www.uniprot.org/uniprot/P24173 charge swissprot:RFAC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RFAC_ECOLI eggNOG COG0859 http://eggnogapi.embl.de/nog_data/html/tree/COG0859 eggNOG ENOG4105D16 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D16 epestfind swissprot:RFAC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RFAC_ECOLI garnier swissprot:RFAC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RFAC_ECOLI helixturnhelix swissprot:RFAC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RFAC_ECOLI hmoment swissprot:RFAC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RFAC_ECOLI iep swissprot:RFAC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RFAC_ECOLI inforesidue swissprot:RFAC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RFAC_ECOLI octanol swissprot:RFAC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RFAC_ECOLI pepcoil swissprot:RFAC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RFAC_ECOLI pepdigest swissprot:RFAC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RFAC_ECOLI pepinfo swissprot:RFAC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RFAC_ECOLI pepnet swissprot:RFAC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RFAC_ECOLI pepstats swissprot:RFAC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RFAC_ECOLI pepwheel swissprot:RFAC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RFAC_ECOLI pepwindow swissprot:RFAC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RFAC_ECOLI sigcleave swissprot:RFAC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RFAC_ECOLI ## Database ID URL or Descriptions # BioGrid 4260277 13 # CDD cd00118 LysM # DISRUPTION PHENOTYPE Simultaneous disruption of erfK, ybiS, ycfS and ynhG leads to loss of covalent anchoring of the major outer membrane lipoprotein (Lpp) to the peptidoglycan. Overexpression of ynhG in this background increases meso-diaminopimelyl-3-a meso- diaminopimelyl-3 cross-links but does not restore Lpp anchoring. {ECO:0000269|PubMed 18456808}. # EcoGene EG14015 ynhG # FUNCTION YNHG_ECOLI Responsible, at least in part, for generating a meso- diaminopimelyl-3-a meso-diaminopimelyl-3 cross-link. {ECO 0000269|PubMed 18456808}. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_function GO:0016755 transferase activity, transferring amino-acyl groups; IMP:EcoCyc. # GO_function GO:0016757 transferase activity, transferring glycosyl groups; IEA:UniProtKB-KW. # GO_function GO:0016807 cysteine-type carboxypeptidase activity; IMP:EcoCyc. # GO_function GO:0071972 peptidoglycan L,D-transpeptidase activity; IMP:EcoCyc. # GO_process GO:0008360 regulation of cell shape; IEA:UniProtKB-KW. # GO_process GO:0009252 peptidoglycan biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0043164 Gram-negative-bacterium-type cell wall biogenesis; IMP:EcoCyc. # GO_process GO:0044036 cell wall macromolecule metabolic process; IMP:EcoCyc. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 3.10.350.10 -; 1. # InterPro IPR005490 LD_TPept_cat_dom # InterPro IPR018392 LysM_dom # KEGG_Brite ko01002 Peptidases # Organism YNHG_ECOLI Escherichia coli (strain K12) # PATHWAY YNHG_ECOLI Cell wall biogenesis; peptidoglycan biosynthesis. # PATRIC 32118662 VBIEscCol129921_1749 # PIR F64925 F64925 # PROSITE PS51782 LYSM # Pfam PF01476 LysM # Pfam PF03734 YkuD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNHG_ECOLI Probable L,D-transpeptidase YnhG # RefSeq NP_416193 NC_000913.3 # RefSeq WP_000817105 NZ_LN832404.1 # SIMILARITY Belongs to the YkuD family. {ECO 0000305}. # SIMILARITY Contains 1 LysM domain. {ECO:0000255|PROSITE- ProRule PRU01118}. # SMART SM00257 LysM # SUBCELLULAR LOCATION YNHG_ECOLI Periplasm {ECO 0000305}. # SUBUNIT Interacts with DsbG. {ECO:0000269|PubMed 19965429}. # eggNOG COG1376 LUCA # eggNOG ENOG4107N1Q Bacteria BLAST swissprot:YNHG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNHG_ECOLI BioCyc ECOL316407:JW1668-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1668-MONOMER BioCyc EcoCyc:G6904-MONOMER http://biocyc.org/getid?id=EcoCyc:G6904-MONOMER BioCyc MetaCyc:G6904-MONOMER http://biocyc.org/getid?id=MetaCyc:G6904-MONOMER COG COG1376 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1376 DIP DIP-12774N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12774N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1179557 http://dx.doi.org/10.1126/science.1179557 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00025-08 http://dx.doi.org/10.1128/JB.00025-08 EC_number EC:2.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:2.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.-.-.- http://enzyme.expasy.org/EC/2.-.-.- EchoBASE EB3771 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3771 EcoGene EG14015 http://www.ecogene.org/geneInfo.php?eg_id=EG14015 EnsemblBacteria AAC74748 http://www.ensemblgenomes.org/id/AAC74748 EnsemblBacteria AAC74748 http://www.ensemblgenomes.org/id/AAC74748 EnsemblBacteria BAA15458 http://www.ensemblgenomes.org/id/BAA15458 EnsemblBacteria BAA15458 http://www.ensemblgenomes.org/id/BAA15458 EnsemblBacteria BAA15458 http://www.ensemblgenomes.org/id/BAA15458 EnsemblBacteria b1678 http://www.ensemblgenomes.org/id/b1678 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0016755 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016755 GO_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GO_function GO:0016807 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016807 GO_function GO:0071972 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071972 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0009252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009252 GO_process GO:0043164 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043164 GO_process GO:0044036 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044036 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 3.10.350.10 http://www.cathdb.info/version/latest/superfamily/3.10.350.10 GeneID 946174 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946174 HOGENOM HOG000274378 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000274378&db=HOGENOM6 InParanoid P76193 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76193 IntAct P76193 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76193* IntEnz 2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2 InterPro IPR005490 http://www.ebi.ac.uk/interpro/entry/IPR005490 InterPro IPR018392 http://www.ebi.ac.uk/interpro/entry/IPR018392 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW1668 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1668 KEGG_Gene eco:b1678 http://www.genome.jp/dbget-bin/www_bget?eco:b1678 KEGG_Orthology KO:K16291 http://www.genome.jp/dbget-bin/www_bget?KO:K16291 MINT MINT-1318911 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1318911 OMA HVIKAKY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HVIKAKY PROSITE PS51782 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51782 PSORT swissprot:YNHG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNHG_ECOLI PSORT-B swissprot:YNHG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNHG_ECOLI PSORT2 swissprot:YNHG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNHG_ECOLI Pfam PF01476 http://pfam.xfam.org/family/PF01476 Pfam PF03734 http://pfam.xfam.org/family/PF03734 Phobius swissprot:YNHG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNHG_ECOLI PhylomeDB P76193 http://phylomedb.org/?seqid=P76193 ProteinModelPortal P76193 http://www.proteinmodelportal.org/query/uniprot/P76193 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18456808 http://www.ncbi.nlm.nih.gov/pubmed/18456808 PubMed 19965429 http://www.ncbi.nlm.nih.gov/pubmed/19965429 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416193 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416193 RefSeq WP_000817105 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000817105 SMART SM00257 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00257 SMR P76193 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76193 STRING 511145.b1678 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1678&targetmode=cogs STRING COG1376 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1376&targetmode=cogs UniProtKB YNHG_ECOLI http://www.uniprot.org/uniprot/YNHG_ECOLI UniProtKB-AC P76193 http://www.uniprot.org/uniprot/P76193 charge swissprot:YNHG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNHG_ECOLI eggNOG COG1376 http://eggnogapi.embl.de/nog_data/html/tree/COG1376 eggNOG ENOG4107N1Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107N1Q epestfind swissprot:YNHG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNHG_ECOLI garnier swissprot:YNHG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNHG_ECOLI helixturnhelix swissprot:YNHG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNHG_ECOLI hmoment swissprot:YNHG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNHG_ECOLI iep swissprot:YNHG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNHG_ECOLI inforesidue swissprot:YNHG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNHG_ECOLI octanol swissprot:YNHG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNHG_ECOLI pepcoil swissprot:YNHG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNHG_ECOLI pepdigest swissprot:YNHG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNHG_ECOLI pepinfo swissprot:YNHG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNHG_ECOLI pepnet swissprot:YNHG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNHG_ECOLI pepstats swissprot:YNHG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNHG_ECOLI pepwheel swissprot:YNHG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNHG_ECOLI pepwindow swissprot:YNHG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNHG_ECOLI sigcleave swissprot:YNHG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNHG_ECOLI ## Database ID URL or Descriptions # AltName FECB_ECOLI Iron(III) dicitrate-binding periplasmic protein # BioGrid 4261562 211 # EcoGene EG10287 fecB # FUNCTION FECB_ECOLI Binds citrate-dependent Fe(3+); part of the binding- protein-dependent transport system for uptake of citrate-dependent Fe(3+). # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_process GO:0006811 ion transport; IEA:UniProtKB-KW. # GO_process GO:0055072 iron ion homeostasis; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0006810 transport # GOslim_process GO:0042592 homeostatic process # INDUCTION Induced 1.8-fold by hydroxyurea. {ECO:0000269|PubMed 20005847}. # IntAct P15028 10 # InterPro IPR002491 ABC_transptr_periplasmic_BD # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00240 Iron complex transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism FECB_ECOLI Escherichia coli (strain K12) # PATRIC 32124159 VBIEscCol129921_4423 # PIR S56515 QRECD3 # PROSITE PS50983 FE_B12_PBP # Pfam PF01497 Peripla_BP_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FECB_ECOLI Fe(3+) dicitrate-binding periplasmic protein # RefSeq NP_418710 NC_000913.3 # RefSeq WP_000879155 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97186.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the bacterial solute-binding protein 8 family. {ECO 0000305}. # SIMILARITY Contains 1 Fe/B12 periplasmic-binding domain. {ECO:0000255|PROSITE-ProRule PRU00344}. # SUBCELLULAR LOCATION FECB_ECOLI Periplasm. # TCDB 3.A.1.14 the atp-binding cassette (abc) superfamily # eggNOG COG4594 LUCA # eggNOG ENOG4108HUF Bacteria BLAST swissprot:FECB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FECB_ECOLI BioCyc ECOL316407:JW4250-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4250-MONOMER BioCyc EcoCyc:FECB-MONOMER http://biocyc.org/getid?id=EcoCyc:FECB-MONOMER BioCyc MetaCyc:FECB-MONOMER http://biocyc.org/getid?id=MetaCyc:FECB-MONOMER COG COG0614 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0614 DIP DIP-9584N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9584N DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M26397 http://www.ebi.ac.uk/ena/data/view/M26397 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB0283 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0283 EcoGene EG10287 http://www.ecogene.org/geneInfo.php?eg_id=EG10287 EnsemblBacteria AAC77246 http://www.ensemblgenomes.org/id/AAC77246 EnsemblBacteria AAC77246 http://www.ensemblgenomes.org/id/AAC77246 EnsemblBacteria BAE78281 http://www.ensemblgenomes.org/id/BAE78281 EnsemblBacteria BAE78281 http://www.ensemblgenomes.org/id/BAE78281 EnsemblBacteria BAE78281 http://www.ensemblgenomes.org/id/BAE78281 EnsemblBacteria b4290 http://www.ensemblgenomes.org/id/b4290 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_process GO:0006811 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811 GO_process GO:0055072 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055072 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GeneID 946838 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946838 HOGENOM HOG000045521 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000045521&db=HOGENOM6 InParanoid P15028 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P15028 IntAct P15028 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P15028* InterPro IPR002491 http://www.ebi.ac.uk/interpro/entry/IPR002491 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW4250 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4250 KEGG_Gene eco:b4290 http://www.genome.jp/dbget-bin/www_bget?eco:b4290 KEGG_Orthology KO:K02016 http://www.genome.jp/dbget-bin/www_bget?KO:K02016 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 MINT MINT-1275090 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1275090 OMA QPAYLEN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QPAYLEN PROSITE PS50983 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50983 PSORT swissprot:FECB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FECB_ECOLI PSORT-B swissprot:FECB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FECB_ECOLI PSORT2 swissprot:FECB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FECB_ECOLI Pfam PF01497 http://pfam.xfam.org/family/PF01497 Phobius swissprot:FECB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FECB_ECOLI PhylomeDB P15028 http://phylomedb.org/?seqid=P15028 ProteinModelPortal P15028 http://www.proteinmodelportal.org/query/uniprot/P15028 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 2651410 http://www.ncbi.nlm.nih.gov/pubmed/2651410 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418710 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418710 RefSeq WP_000879155 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000879155 SMR P15028 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P15028 STRING 511145.b4290 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4290&targetmode=cogs STRING COG0614 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0614&targetmode=cogs TCDB 3.A.1.14 http://www.tcdb.org/search/result.php?tc=3.A.1.14 UniProtKB FECB_ECOLI http://www.uniprot.org/uniprot/FECB_ECOLI UniProtKB-AC P15028 http://www.uniprot.org/uniprot/P15028 charge swissprot:FECB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FECB_ECOLI eggNOG COG4594 http://eggnogapi.embl.de/nog_data/html/tree/COG4594 eggNOG ENOG4108HUF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108HUF epestfind swissprot:FECB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FECB_ECOLI garnier swissprot:FECB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FECB_ECOLI helixturnhelix swissprot:FECB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FECB_ECOLI hmoment swissprot:FECB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FECB_ECOLI iep swissprot:FECB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FECB_ECOLI inforesidue swissprot:FECB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FECB_ECOLI octanol swissprot:FECB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FECB_ECOLI pepcoil swissprot:FECB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FECB_ECOLI pepdigest swissprot:FECB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FECB_ECOLI pepinfo swissprot:FECB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FECB_ECOLI pepnet swissprot:FECB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FECB_ECOLI pepstats swissprot:FECB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FECB_ECOLI pepwheel swissprot:FECB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FECB_ECOLI pepwindow swissprot:FECB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FECB_ECOLI sigcleave swissprot:FECB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FECB_ECOLI ## Database ID URL or Descriptions # BioGrid 4261689 74 # EcoGene EG11137 yebC # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-HAMAP. # GO_process GO:0010212 response to ionizing radiation; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.200 -; 1. # Gene3D 3.30.1270.10 -; 2. # Gene3D 3.30.70.980 -; 1. # HAMAP MF_00693 Transcrip_reg_TACO1 # IntAct P0A8A0 22 # InterPro IPR002876 Transcrip_reg_TACO1-like # InterPro IPR017856 Integrase_Zn-bd_dom-like_N # InterPro IPR026563 Transcrip_reg_TACO1-like_dom2 # InterPro IPR026564 Transcrip_reg_TACO1-like_dom3 # InterPro IPR029072 YebC-like # Organism YEBC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR12532 PTHR12532 # PATRIC 32119051 VBIEscCol129921_1943 # PDB 1KON X-ray; 2.20 A; A=1-246 # PIR C38113 C38113 # Pfam PF01709 Transcrip_reg # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Probable transcriptional regulatory protein YebC {ECO:0000255|HAMAP-Rule MF_00693} # RefSeq NP_416378 NC_000913.3 # RefSeq WP_000907248 NZ_LN832404.1 # SIMILARITY Belongs to the TACO1 family. {ECO:0000255|HAMAP- Rule MF_00693}. # SUBCELLULAR LOCATION YEBC_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00693}. # SUPFAM SSF75625 SSF75625 # TIGRFAMs TIGR01033 TIGR01033 # eggNOG COG0217 LUCA # eggNOG ENOG4105CDY Bacteria BLAST swissprot:YEBC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEBC_ECOLI BioCyc ECOL316407:JW1853-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1853-MONOMER BioCyc EcoCyc:EG11137-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11137-MONOMER DIP DIP-47886N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47886N DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D10165 http://www.ebi.ac.uk/ena/data/view/D10165 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X59551 http://www.ebi.ac.uk/ena/data/view/X59551 EchoBASE EB1127 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1127 EcoGene EG11137 http://www.ecogene.org/geneInfo.php?eg_id=EG11137 EnsemblBacteria AAC74934 http://www.ensemblgenomes.org/id/AAC74934 EnsemblBacteria AAC74934 http://www.ensemblgenomes.org/id/AAC74934 EnsemblBacteria BAA15675 http://www.ensemblgenomes.org/id/BAA15675 EnsemblBacteria BAA15675 http://www.ensemblgenomes.org/id/BAA15675 EnsemblBacteria BAA15675 http://www.ensemblgenomes.org/id/BAA15675 EnsemblBacteria b1864 http://www.ensemblgenomes.org/id/b1864 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0010212 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010212 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.200 http://www.cathdb.info/version/latest/superfamily/1.10.10.200 Gene3D 3.30.1270.10 http://www.cathdb.info/version/latest/superfamily/3.30.1270.10 Gene3D 3.30.70.980 http://www.cathdb.info/version/latest/superfamily/3.30.70.980 GeneID 946379 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946379 HAMAP MF_00693 http://hamap.expasy.org/unirule/MF_00693 HOGENOM HOG000228370 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000228370&db=HOGENOM6 InParanoid P0A8A0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8A0 IntAct P0A8A0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8A0* InterPro IPR002876 http://www.ebi.ac.uk/interpro/entry/IPR002876 InterPro IPR017856 http://www.ebi.ac.uk/interpro/entry/IPR017856 InterPro IPR026563 http://www.ebi.ac.uk/interpro/entry/IPR026563 InterPro IPR026564 http://www.ebi.ac.uk/interpro/entry/IPR026564 InterPro IPR029072 http://www.ebi.ac.uk/interpro/entry/IPR029072 KEGG_Gene ecj:JW1853 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1853 KEGG_Gene eco:b1864 http://www.genome.jp/dbget-bin/www_bget?eco:b1864 MINT MINT-1241216 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1241216 OMA MTRNGGS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MTRNGGS PANTHER PTHR12532 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12532 PDB 1KON http://www.ebi.ac.uk/pdbe-srv/view/entry/1KON PDBsum 1KON http://www.ebi.ac.uk/pdbsum/1KON PSORT swissprot:YEBC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEBC_ECOLI PSORT-B swissprot:YEBC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEBC_ECOLI PSORT2 swissprot:YEBC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEBC_ECOLI Pfam PF01709 http://pfam.xfam.org/family/PF01709 Phobius swissprot:YEBC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEBC_ECOLI PhylomeDB P0A8A0 http://phylomedb.org/?seqid=P0A8A0 ProteinModelPortal P0A8A0 http://www.proteinmodelportal.org/query/uniprot/P0A8A0 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 1657895 http://www.ncbi.nlm.nih.gov/pubmed/1657895 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1885548 http://www.ncbi.nlm.nih.gov/pubmed/1885548 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416378 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416378 RefSeq WP_000907248 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000907248 SMR P0A8A0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8A0 STRING 511145.b1864 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1864&targetmode=cogs SUPFAM SSF75625 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF75625 TIGRFAMs TIGR01033 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01033 UniProtKB YEBC_ECOLI http://www.uniprot.org/uniprot/YEBC_ECOLI UniProtKB-AC P0A8A0 http://www.uniprot.org/uniprot/P0A8A0 charge swissprot:YEBC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEBC_ECOLI eggNOG COG0217 http://eggnogapi.embl.de/nog_data/html/tree/COG0217 eggNOG ENOG4105CDY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CDY epestfind swissprot:YEBC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEBC_ECOLI garnier swissprot:YEBC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEBC_ECOLI helixturnhelix swissprot:YEBC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEBC_ECOLI hmoment swissprot:YEBC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEBC_ECOLI iep swissprot:YEBC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEBC_ECOLI inforesidue swissprot:YEBC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEBC_ECOLI octanol swissprot:YEBC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEBC_ECOLI pepcoil swissprot:YEBC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEBC_ECOLI pepdigest swissprot:YEBC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEBC_ECOLI pepinfo swissprot:YEBC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEBC_ECOLI pepnet swissprot:YEBC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEBC_ECOLI pepstats swissprot:YEBC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEBC_ECOLI pepwheel swissprot:YEBC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEBC_ECOLI pepwindow swissprot:YEBC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEBC_ECOLI sigcleave swissprot:YEBC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEBC_ECOLI ## Database ID URL or Descriptions # EcoGene EG14483 yoeI # INDUCTION YOEI_ECOLI In exponential phase (PubMed 19121005) repressed in minimal glycerol medium, repressed in low oxygen (PubMed 19734316) (at protein level). {ECO 0000269|PubMed 19121005, ECO 0000269|PubMed 19734316}. # Organism YOEI_ECOLI Escherichia coli (strain K12) # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YOEI_ECOLI Uncharacterized protein YoeI # RefSeq YP_002791246 NC_000913.3 BLAST swissprot:YOEI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YOEI_ECOLI BioCyc EcoCyc:MONOMER0-2870 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2870 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2008.06495.x http://dx.doi.org/10.1111/j.1365-2958.2008.06495.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00872-09 http://dx.doi.org/10.1128/JB.00872-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14483 http://www.ecogene.org/geneInfo.php?eg_id=EG14483 EnsemblBacteria ACO59998 http://www.ensemblgenomes.org/id/ACO59998 EnsemblBacteria ACO59998 http://www.ensemblgenomes.org/id/ACO59998 EnsemblBacteria b4678 http://www.ensemblgenomes.org/id/b4678 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 7751643 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7751643 KEGG_Gene eco:b4678 http://www.genome.jp/dbget-bin/www_bget?eco:b4678 PSORT swissprot:YOEI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YOEI_ECOLI PSORT-B swissprot:YOEI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YOEI_ECOLI PSORT2 swissprot:YOEI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YOEI_ECOLI Phobius swissprot:YOEI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YOEI_ECOLI PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19121005 http://www.ncbi.nlm.nih.gov/pubmed/19121005 PubMed 19734316 http://www.ncbi.nlm.nih.gov/pubmed/19734316 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq YP_002791246 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_002791246 STRING 511145.b4678 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4678&targetmode=cogs UniProtKB YOEI_ECOLI http://www.uniprot.org/uniprot/YOEI_ECOLI UniProtKB-AC C1P606 http://www.uniprot.org/uniprot/C1P606 charge swissprot:YOEI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YOEI_ECOLI epestfind swissprot:YOEI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YOEI_ECOLI garnier swissprot:YOEI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YOEI_ECOLI helixturnhelix swissprot:YOEI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YOEI_ECOLI hmoment swissprot:YOEI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YOEI_ECOLI iep swissprot:YOEI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YOEI_ECOLI inforesidue swissprot:YOEI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YOEI_ECOLI octanol swissprot:YOEI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YOEI_ECOLI pepcoil swissprot:YOEI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YOEI_ECOLI pepdigest swissprot:YOEI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YOEI_ECOLI pepinfo swissprot:YOEI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YOEI_ECOLI pepnet swissprot:YOEI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YOEI_ECOLI pepstats swissprot:YOEI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YOEI_ECOLI pepwheel swissprot:YOEI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YOEI_ECOLI pepwindow swissprot:YOEI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YOEI_ECOLI sigcleave swissprot:YOEI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YOEI_ECOLI ## Database ID URL or Descriptions # BioGrid 4259612 9 # EcoGene EG11469 rhtB # FUNCTION RHTB_ECOLI Conducts the efflux of homoserine and homoserine lactone. {ECO 0000269|PubMed 10386596}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0042970 homoserine transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0042968 homoserine transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR001123 LysE-type # InterPro IPR004778 Homoserine/Threonine_efflux # KEGG_Brite ko02000 Transporters # Organism RHTB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30086 PTHR30086 # PATRIC 32123149 VBIEscCol129921_3940 # PIRSF PIRSF006324 LeuE # Pfam PF01810 LysE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RHTB_ECOLI Homoserine/homoserine lactone efflux protein # RefSeq WP_000171710 NZ_LN832404.1 # RefSeq YP_026265 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA67620.1; Type=Frameshift; Positions=60; Evidence={ECO 0000305}; # SIMILARITY Belongs to the rht family. {ECO 0000305}. # SUBCELLULAR LOCATION RHTB_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # TCDB 2.A.76.1 the resistance to homoserine/threonine (rhtb) family # TIGRFAMs TIGR00949 2A76 # eggNOG COG1280 LUCA # eggNOG ENOG410829K Bacteria BLAST swissprot:RHTB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RHTB_ECOLI BioCyc ECOL316407:JW5585-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5585-MONOMER BioCyc EcoCyc:RHTB-MONOMER http://biocyc.org/getid?id=EcoCyc:RHTB-MONOMER BioCyc MetaCyc:RHTB-MONOMER http://biocyc.org/getid?id=MetaCyc:RHTB-MONOMER COG COG1280 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1280 DOI 10.1016/S0014-5793(99)00625-0 http://dx.doi.org/10.1016/S0014-5793(99)00625-0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1437 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1437 EcoGene EG11469 http://www.ecogene.org/geneInfo.php?eg_id=EG11469 EnsemblBacteria AAT48223 http://www.ensemblgenomes.org/id/AAT48223 EnsemblBacteria AAT48223 http://www.ensemblgenomes.org/id/AAT48223 EnsemblBacteria BAE77477 http://www.ensemblgenomes.org/id/BAE77477 EnsemblBacteria BAE77477 http://www.ensemblgenomes.org/id/BAE77477 EnsemblBacteria BAE77477 http://www.ensemblgenomes.org/id/BAE77477 EnsemblBacteria b3824 http://www.ensemblgenomes.org/id/b3824 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0042970 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042970 GO_process GO:0042968 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042968 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948316 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948316 HOGENOM HOG000122945 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122945&db=HOGENOM6 InParanoid P0AG34 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AG34 InterPro IPR001123 http://www.ebi.ac.uk/interpro/entry/IPR001123 InterPro IPR004778 http://www.ebi.ac.uk/interpro/entry/IPR004778 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5585 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5585 KEGG_Gene eco:b3824 http://www.genome.jp/dbget-bin/www_bget?eco:b3824 KEGG_Orthology KO:K05834 http://www.genome.jp/dbget-bin/www_bget?KO:K05834 OMA ICGLQLG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ICGLQLG PANTHER PTHR30086 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30086 PSORT swissprot:RHTB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RHTB_ECOLI PSORT-B swissprot:RHTB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RHTB_ECOLI PSORT2 swissprot:RHTB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RHTB_ECOLI Pfam PF01810 http://pfam.xfam.org/family/PF01810 Phobius swissprot:RHTB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RHTB_ECOLI PhylomeDB P0AG34 http://phylomedb.org/?seqid=P0AG34 ProteinModelPortal P0AG34 http://www.proteinmodelportal.org/query/uniprot/P0AG34 PubMed 10386596 http://www.ncbi.nlm.nih.gov/pubmed/10386596 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000171710 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000171710 RefSeq YP_026265 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026265 STRING 511145.b3824 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3824&targetmode=cogs STRING COG1280 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1280&targetmode=cogs TCDB 2.A.76.1 http://www.tcdb.org/search/result.php?tc=2.A.76.1 TIGRFAMs TIGR00949 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00949 UniProtKB RHTB_ECOLI http://www.uniprot.org/uniprot/RHTB_ECOLI UniProtKB-AC P0AG34 http://www.uniprot.org/uniprot/P0AG34 charge swissprot:RHTB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RHTB_ECOLI eggNOG COG1280 http://eggnogapi.embl.de/nog_data/html/tree/COG1280 eggNOG ENOG410829K http://eggnogapi.embl.de/nog_data/html/tree/ENOG410829K epestfind swissprot:RHTB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RHTB_ECOLI garnier swissprot:RHTB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RHTB_ECOLI helixturnhelix swissprot:RHTB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RHTB_ECOLI hmoment swissprot:RHTB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RHTB_ECOLI iep swissprot:RHTB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RHTB_ECOLI inforesidue swissprot:RHTB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RHTB_ECOLI octanol swissprot:RHTB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RHTB_ECOLI pepcoil swissprot:RHTB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RHTB_ECOLI pepdigest swissprot:RHTB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RHTB_ECOLI pepinfo swissprot:RHTB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RHTB_ECOLI pepnet swissprot:RHTB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RHTB_ECOLI pepstats swissprot:RHTB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RHTB_ECOLI pepwheel swissprot:RHTB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RHTB_ECOLI pepwindow swissprot:RHTB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RHTB_ECOLI sigcleave swissprot:RHTB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RHTB_ECOLI ## Database ID URL or Descriptions # Organism YUBE_ECOLI Escherichia coli (strain K12) # RecName YUBE_ECOLI Uncharacterized protein YubE # RefSeq NP_061432 NC_002483.1 # RefSeq WP_001104904 NZ_CP014273.1 BLAST swissprot:YUBE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YUBE_ECOLI DOI 10.1006/plas.1999.1390 http://dx.doi.org/10.1006/plas.1999.1390 EMBL AF106329 http://www.ebi.ac.uk/ena/data/view/AF106329 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1263491 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263491 OMA ALSNAMC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ALSNAMC PSORT swissprot:YUBE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YUBE_ECOLI PSORT-B swissprot:YUBE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YUBE_ECOLI PSORT2 swissprot:YUBE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YUBE_ECOLI Phobius swissprot:YUBE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YUBE_ECOLI ProteinModelPortal Q9S4X1 http://www.proteinmodelportal.org/query/uniprot/Q9S4X1 PubMed 10366527 http://www.ncbi.nlm.nih.gov/pubmed/10366527 RefSeq NP_061432 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061432 RefSeq WP_001104904 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001104904 UniProtKB YUBE_ECOLI http://www.uniprot.org/uniprot/YUBE_ECOLI UniProtKB-AC Q9S4X1 http://www.uniprot.org/uniprot/Q9S4X1 charge swissprot:YUBE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YUBE_ECOLI epestfind swissprot:YUBE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YUBE_ECOLI garnier swissprot:YUBE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YUBE_ECOLI helixturnhelix swissprot:YUBE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YUBE_ECOLI hmoment swissprot:YUBE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YUBE_ECOLI iep swissprot:YUBE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YUBE_ECOLI inforesidue swissprot:YUBE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YUBE_ECOLI octanol swissprot:YUBE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YUBE_ECOLI pepcoil swissprot:YUBE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YUBE_ECOLI pepdigest swissprot:YUBE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YUBE_ECOLI pepinfo swissprot:YUBE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YUBE_ECOLI pepnet swissprot:YUBE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YUBE_ECOLI pepstats swissprot:YUBE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YUBE_ECOLI pepwheel swissprot:YUBE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YUBE_ECOLI pepwindow swissprot:YUBE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YUBE_ECOLI sigcleave swissprot:YUBE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YUBE_ECOLI ## Database ID URL or Descriptions # AltName ASSY_ECOLI Citrulline--aspartate ligase # BioGrid 4263121 14 # CATALYTIC ACTIVITY ASSY_ECOLI ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate. # CDD cd01999 Argininosuccinate_Synthase # DOMAIN ASSY_ECOLI The monomer is composed of two major structural domains a nucleotide-binding domain and a catalytic/multimerization domain. Binding of ATP results in a large rigid body conformational change of the nucleotide binding domain. # DrugBank DB00536 Guanidine # EcoGene EG10068 argG # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004055 argininosuccinate synthase activity; IBA:GO_Central. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_process GO:0000050 urea cycle; IBA:GO_Central. # GO_process GO:0000053 argininosuccinate metabolic process; IBA:GO_Central. # GO_process GO:0006526 arginine biosynthetic process; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0071941 nitrogen cycle metabolic process # Gene3D 1.10.287.400 -; 1. # Gene3D 3.40.50.620 -; 1. # Gene3D 3.90.1260.10 -; 1. # HAMAP MF_00581 Arg_succ_synth_type2 # INTERACTION ASSY_ECOLI P24228 dacB; NbExp=2; IntAct=EBI-1120296, EBI-1131834; # IntAct P0A6E4 13 # InterPro IPR001518 Arginosuc_synth # InterPro IPR014729 Rossmann-like_a/b/a_fold # InterPro IPR018223 Arginosuc_synth_CS # InterPro IPR023434 Arginosuc_synth_type_1_subfam # InterPro IPR023437 Arg_succ_synth_type2_subfam # InterPro IPR024073 AS_multimer_C_tail # InterPro IPR024074 AS_cat/multimer_dom_body # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00250 Alanine, aspartate and glutamate metabolism # KEGG_Pathway ko00330 Arginine and proline metabolism # Organism ASSY_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-arginine biosynthesis; L- arginine from L-ornithine and carbamoyl phosphate step 2/3. # PATRIC 32121762 VBIEscCol129921_3266 # PDB 1K92 X-ray; 1.60 A; A=2-447 # PDB 1K97 X-ray; 2.00 A; A=2-447 # PDB 1KP2 X-ray; 2.00 A; A=2-447 # PDB 1KP3 X-ray; 2.00 A; A=2-447 # PIR G65107 AJECRS # PROSITE PS00564 ARGININOSUCCIN_SYN_1 # PROSITE PS00565 ARGININOSUCCIN_SYN_2 # Pfam PF00764 Arginosuc_synth # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ASSY_ECOLI Argininosuccinate synthase # RefSeq NP_417640 NC_000913.3 # RefSeq WP_000207680 NZ_LN832404.1 # SIMILARITY Belongs to the argininosuccinate synthase family. Type 2 subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION ASSY_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT ASSY_ECOLI Homotetramer. {ECO 0000269|PubMed 11738042, ECO 0000269|PubMed 11809762}. # TIGRFAMs TIGR00032 argG # UniPathway UPA00068 UER00113 # eggNOG COG0137 LUCA # eggNOG ENOG4105CDH Bacteria BLAST swissprot:ASSY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ASSY_ECOLI BioCyc ECOL316407:JW3140-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3140-MONOMER BioCyc EcoCyc:ARGSUCCINSYN-MONOMER http://biocyc.org/getid?id=EcoCyc:ARGSUCCINSYN-MONOMER COG COG0137 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0137 DIP DIP-35842N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35842N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1016/0378-1119(90)90419-R http://dx.doi.org/10.1016/0378-1119(90)90419-R DOI 10.1016/S0969-2126(01)00683-9 http://dx.doi.org/10.1016/S0969-2126(01)00683-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M112436200 http://dx.doi.org/10.1074/jbc.M112436200 DOI 10.1107/S0907444999011816 http://dx.doi.org/10.1107/S0907444999011816 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB00536 http://www.drugbank.ca/drugs/DB00536 EC_number EC:6.3.4.5 http://www.genome.jp/dbget-bin/www_bget?EC:6.3.4.5 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M35236 http://www.ebi.ac.uk/ena/data/view/M35236 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 6.3.4.5 http://enzyme.expasy.org/EC/6.3.4.5 EchoBASE EB0066 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0066 EcoGene EG10068 http://www.ecogene.org/geneInfo.php?eg_id=EG10068 EnsemblBacteria AAC76205 http://www.ensemblgenomes.org/id/AAC76205 EnsemblBacteria AAC76205 http://www.ensemblgenomes.org/id/AAC76205 EnsemblBacteria BAE77217 http://www.ensemblgenomes.org/id/BAE77217 EnsemblBacteria BAE77217 http://www.ensemblgenomes.org/id/BAE77217 EnsemblBacteria BAE77217 http://www.ensemblgenomes.org/id/BAE77217 EnsemblBacteria b3172 http://www.ensemblgenomes.org/id/b3172 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004055 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0000050 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000050 GO_process GO:0000053 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000053 GO_process GO:0006526 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006526 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0071941 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071941 Gene3D 1.10.287.400 http://www.cathdb.info/version/latest/superfamily/1.10.287.400 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 Gene3D 3.90.1260.10 http://www.cathdb.info/version/latest/superfamily/3.90.1260.10 GeneID 947590 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947590 HAMAP MF_00581 http://hamap.expasy.org/unirule/MF_00581 HOGENOM HOG000230094 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230094&db=HOGENOM6 InParanoid P0A6E4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6E4 IntAct P0A6E4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6E4* IntEnz 6.3.4.5 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.4.5 InterPro IPR001518 http://www.ebi.ac.uk/interpro/entry/IPR001518 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 InterPro IPR018223 http://www.ebi.ac.uk/interpro/entry/IPR018223 InterPro IPR023434 http://www.ebi.ac.uk/interpro/entry/IPR023434 InterPro IPR023437 http://www.ebi.ac.uk/interpro/entry/IPR023437 InterPro IPR024073 http://www.ebi.ac.uk/interpro/entry/IPR024073 InterPro IPR024074 http://www.ebi.ac.uk/interpro/entry/IPR024074 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3140 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3140 KEGG_Gene eco:b3172 http://www.genome.jp/dbget-bin/www_bget?eco:b3172 KEGG_Orthology KO:K01940 http://www.genome.jp/dbget-bin/www_bget?KO:K01940 KEGG_Pathway ko00250 http://www.genome.jp/kegg-bin/show_pathway?ko00250 KEGG_Pathway ko00330 http://www.genome.jp/kegg-bin/show_pathway?ko00330 KEGG_Reaction rn:R01954 http://www.genome.jp/dbget-bin/www_bget?rn:R01954 OMA AFHIRSG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AFHIRSG PDB 1K92 http://www.ebi.ac.uk/pdbe-srv/view/entry/1K92 PDB 1K97 http://www.ebi.ac.uk/pdbe-srv/view/entry/1K97 PDB 1KP2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1KP2 PDB 1KP3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1KP3 PDBsum 1K92 http://www.ebi.ac.uk/pdbsum/1K92 PDBsum 1K97 http://www.ebi.ac.uk/pdbsum/1K97 PDBsum 1KP2 http://www.ebi.ac.uk/pdbsum/1KP2 PDBsum 1KP3 http://www.ebi.ac.uk/pdbsum/1KP3 PROSITE PS00564 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00564 PROSITE PS00565 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00565 PSORT swissprot:ASSY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ASSY_ECOLI PSORT-B swissprot:ASSY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ASSY_ECOLI PSORT2 swissprot:ASSY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ASSY_ECOLI Pfam PF00764 http://pfam.xfam.org/family/PF00764 Phobius swissprot:ASSY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ASSY_ECOLI PhylomeDB P0A6E4 http://phylomedb.org/?seqid=P0A6E4 ProteinModelPortal P0A6E4 http://www.proteinmodelportal.org/query/uniprot/P0A6E4 PubMed 10666579 http://www.ncbi.nlm.nih.gov/pubmed/10666579 PubMed 11738042 http://www.ncbi.nlm.nih.gov/pubmed/11738042 PubMed 11809762 http://www.ncbi.nlm.nih.gov/pubmed/11809762 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2123815 http://www.ncbi.nlm.nih.gov/pubmed/2123815 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_417640 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417640 RefSeq WP_000207680 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000207680 SMR P0A6E4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6E4 STRING 511145.b3172 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3172&targetmode=cogs STRING COG0137 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0137&targetmode=cogs SWISS-2DPAGE P0A6E4 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A6E4 TIGRFAMs TIGR00032 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00032 UniProtKB ASSY_ECOLI http://www.uniprot.org/uniprot/ASSY_ECOLI UniProtKB-AC P0A6E4 http://www.uniprot.org/uniprot/P0A6E4 charge swissprot:ASSY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ASSY_ECOLI eggNOG COG0137 http://eggnogapi.embl.de/nog_data/html/tree/COG0137 eggNOG ENOG4105CDH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CDH epestfind swissprot:ASSY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ASSY_ECOLI garnier swissprot:ASSY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ASSY_ECOLI helixturnhelix swissprot:ASSY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ASSY_ECOLI hmoment swissprot:ASSY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ASSY_ECOLI iep swissprot:ASSY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ASSY_ECOLI inforesidue swissprot:ASSY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ASSY_ECOLI octanol swissprot:ASSY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ASSY_ECOLI pepcoil swissprot:ASSY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ASSY_ECOLI pepdigest swissprot:ASSY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ASSY_ECOLI pepinfo swissprot:ASSY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ASSY_ECOLI pepnet swissprot:ASSY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ASSY_ECOLI pepstats swissprot:ASSY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ASSY_ECOLI pepwheel swissprot:ASSY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ASSY_ECOLI pepwindow swissprot:ASSY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ASSY_ECOLI sigcleave swissprot:ASSY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ASSY_ECOLI ## Database ID URL or Descriptions # BioGrid 4263400 7 # EcoGene EG13987 yniB # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR025229 YniB-like # Organism YNIB_ECOLI Escherichia coli (strain K12) # PATRIC 32118759 VBIEscCol129921_1797 # PIR F64931 F64931 # Pfam PF14002 YniB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNIB_ECOLI Uncharacterized protein YniB # RefSeq NP_416240 NC_000913.3 # RefSeq WP_000222163 NZ_LN832404.1 # SIMILARITY To Y.pestis YfeE. {ECO 0000305}. # SUBCELLULAR LOCATION YNIB_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # eggNOG ENOG4107PN8 Bacteria # eggNOG ENOG410YJ19 LUCA BLAST swissprot:YNIB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNIB_ECOLI BioCyc ECOL316407:JW1715-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1715-MONOMER BioCyc EcoCyc:G6931-MONOMER http://biocyc.org/getid?id=EcoCyc:G6931-MONOMER DIP DIP-12776N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12776N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3743 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3743 EcoGene EG13987 http://www.ecogene.org/geneInfo.php?eg_id=EG13987 EnsemblBacteria AAC74796 http://www.ensemblgenomes.org/id/AAC74796 EnsemblBacteria AAC74796 http://www.ensemblgenomes.org/id/AAC74796 EnsemblBacteria BAE76510 http://www.ensemblgenomes.org/id/BAE76510 EnsemblBacteria BAE76510 http://www.ensemblgenomes.org/id/BAE76510 EnsemblBacteria BAE76510 http://www.ensemblgenomes.org/id/BAE76510 EnsemblBacteria b1726 http://www.ensemblgenomes.org/id/b1726 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 945140 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945140 HOGENOM HOG000121041 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000121041&db=HOGENOM6 IntAct P76208 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76208* InterPro IPR025229 http://www.ebi.ac.uk/interpro/entry/IPR025229 KEGG_Gene ecj:JW1715 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1715 KEGG_Gene eco:b1726 http://www.genome.jp/dbget-bin/www_bget?eco:b1726 OMA MVRFNTP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MVRFNTP PSORT swissprot:YNIB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNIB_ECOLI PSORT-B swissprot:YNIB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNIB_ECOLI PSORT2 swissprot:YNIB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNIB_ECOLI Pfam PF14002 http://pfam.xfam.org/family/PF14002 Phobius swissprot:YNIB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNIB_ECOLI ProteinModelPortal P76208 http://www.proteinmodelportal.org/query/uniprot/P76208 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416240 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416240 RefSeq WP_000222163 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000222163 STRING 511145.b1726 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1726&targetmode=cogs UniProtKB YNIB_ECOLI http://www.uniprot.org/uniprot/YNIB_ECOLI UniProtKB-AC P76208 http://www.uniprot.org/uniprot/P76208 charge swissprot:YNIB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNIB_ECOLI eggNOG ENOG4107PN8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107PN8 eggNOG ENOG410YJ19 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YJ19 epestfind swissprot:YNIB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNIB_ECOLI garnier swissprot:YNIB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNIB_ECOLI helixturnhelix swissprot:YNIB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNIB_ECOLI hmoment swissprot:YNIB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNIB_ECOLI iep swissprot:YNIB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNIB_ECOLI inforesidue swissprot:YNIB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNIB_ECOLI octanol swissprot:YNIB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNIB_ECOLI pepcoil swissprot:YNIB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNIB_ECOLI pepdigest swissprot:YNIB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNIB_ECOLI pepinfo swissprot:YNIB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNIB_ECOLI pepnet swissprot:YNIB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNIB_ECOLI pepstats swissprot:YNIB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNIB_ECOLI pepwheel swissprot:YNIB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNIB_ECOLI pepwindow swissprot:YNIB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNIB_ECOLI sigcleave swissprot:YNIB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNIB_ECOLI ## Database ID URL or Descriptions # BioGrid 4262146 193 # COFACTOR DNAG_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_00974}; Note=Binds two Mg(2+) per subunit. {ECO 0000255|HAMAP- Rule MF_00974}; # COFACTOR DNAG_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000255|HAMAP-Rule MF_00974, ECO 0000269|PubMed 1511009, ECO 0000269|PubMed 8679581}; Note=Binds 1 zinc ion per monomer. {ECO 0000255|HAMAP- Rule MF_00974, ECO 0000269|PubMed 1511009, ECO 0000269|PubMed 8679581}; # DOMAIN DNAG_ECOLI Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB- binding domain. {ECO 0000255|HAMAP-Rule MF_00974, ECO 0000269|PubMed 10741967, ECO 0000269|PubMed 15649896, ECO 0000269|PubMed 17010164}. # ENZYME REGULATION Activity can be regulated by an intermolecular trans association between the zinc-binding domain and the catalytic core domain of two different primase molecules. {ECO:0000269|PubMed 16285921}. # EcoGene EG10239 dnaG # FUNCTION DNAG_ECOLI RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. {ECO 0000255|HAMAP-Rule MF_00974, ECO 0000269|PubMed 1511009, ECO 0000269|PubMed 340457}. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:1990077 primosome complex; IEA:UniProtKB-KW. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003896 DNA primase activity; IDA:EcoliWiki. # GO_function GO:0008270 zinc ion binding; IDA:EcoliWiki. # GO_process GO:0006269 DNA replication, synthesis of RNA primer; IMP:CACAO. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 1.10.860.10 -; 1. # Gene3D 3.90.580.10 -; 1. # Gene3D 3.90.980.10 -; 1. # HAMAP MF_00974 DNA_primase_DnaG # INTERACTION DNAG_ECOLI P0ACB0 dnaB; NbExp=3; IntAct=EBI-549259, EBI-548978; P0AGE0 ssb; NbExp=2; IntAct=EBI-549259, EBI-1118620; # IntAct P0ABS5 17 # InterPro IPR002694 Znf_CHC2 # InterPro IPR006171 Toprim_domain # InterPro IPR006295 DNA_primase_DnaG # InterPro IPR013173 DNA_primase_DnaG_DnaB-bd_dom # InterPro IPR013264 DNA_primase_core_N # InterPro IPR016136 DNA_helicase_N/primase_C # InterPro IPR019475 DNA_primase_DnaB-bd # InterPro IPR030846 DnaG_bac # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03032 DNA replication proteins # KEGG_Pathway ko03030 DNA replication # Organism DNAG_ECOLI Escherichia coli (strain K12) # PATRIC 32121546 VBIEscCol129921_3160 # PDB 1DD9 X-ray; 1.60 A; A=111-433 # PDB 1DDE X-ray; 1.70 A; A=111-433 # PDB 1EQN X-ray; 2.90 A; A/B/C/D/E=111-429 # PDB 1T3W X-ray; 2.80 A; A/B=434-581 # PDB 2HAJ NMR; -; A=434-581 # PDB 3B39 X-ray; 2.35 A; A/B=111-429 # PIR A03423 RYEC2 # PIRSF PIRSF002811 DnaG # PROSITE PS50880 TOPRIM # Pfam PF01807 zf-CHC2 # Pfam PF08275 Toprim_N # Pfam PF08278 DnaG_DnaB_bind # Pfam PF10410 DnaB_bind # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DNA primase {ECO:0000255|HAMAP-Rule MF_00974} # RefSeq NP_417538 NC_000913.3 # RefSeq WP_000918827 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA23531.1; Type=Frameshift; Positions=106, 169; Evidence={ECO 0000305}; # SIMILARITY Belongs to the DnaG primase family. {ECO:0000255|HAMAP-Rule MF_00974}. # SIMILARITY Contains 1 Toprim domain. {ECO:0000255|HAMAP- Rule MF_00974}. # SMART SM00400 ZnF_CHCC # SMART SM00493 TOPRIM # SMART SM00766 DnaG_DnaB_bind # SUBUNIT DNAG_ECOLI Monomer. Interacts with DnaB. The primase-helicase complex is composed of up to three DnaG bound to one DnaB hexamer. {ECO 0000255|HAMAP-Rule MF_00974, ECO 0000269|PubMed 14557266, ECO 0000269|PubMed 1511009, ECO 0000269|PubMed 15649896, ECO 0000269|PubMed 17010164, ECO 0000269|PubMed 340457, ECO 0000269|PubMed 8917517}. # TIGRFAMs TIGR01391 dnaG # eggNOG COG0358 LUCA # eggNOG ENOG4105C9G Bacteria BLAST swissprot:DNAG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DNAG_ECOLI BioCyc ECOL316407:JW3038-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3038-MONOMER BioCyc EcoCyc:EG10239-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10239-MONOMER BioCyc MetaCyc:EG10239-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10239-MONOMER COG COG0358 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0358 DIP DIP-47954N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47954N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/jmbi.2000.3844 http://dx.doi.org/10.1006/jmbi.2000.3844 DOI 10.1007/BF00326054 http://dx.doi.org/10.1007/BF00326054 DOI 10.1016/0092-8674(83)90453-1 http://dx.doi.org/10.1016/0092-8674(83)90453-1 DOI 10.1016/0167-4781(92)90047-4 http://dx.doi.org/10.1016/0167-4781(92)90047-4 DOI 10.1016/j.molcel.2005.09.004 http://dx.doi.org/10.1016/j.molcel.2005.09.004 DOI 10.1021/bi952948p http://dx.doi.org/10.1021/bi952948p DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsmb.1373 http://dx.doi.org/10.1038/nsmb.1373 DOI 10.1073/pnas.79.15.4550 http://dx.doi.org/10.1073/pnas.79.15.4550 DOI 10.1073/pnas.93.23.12902 http://dx.doi.org/10.1073/pnas.93.23.12902 DOI 10.1074/jbc.M308956200 http://dx.doi.org/10.1074/jbc.M308956200 DOI 10.1074/jbc.M412645200 http://dx.doi.org/10.1074/jbc.M412645200 DOI 10.1111/j.1742-4658.2006.05495.x http://dx.doi.org/10.1111/j.1742-4658.2006.05495.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1126/science.287.5462.2482 http://dx.doi.org/10.1126/science.287.5462.2482 EC_number EC:2.7.7.- {ECO:0000255|HAMAP-Rule:MF_00974} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.- {ECO:0000255|HAMAP-Rule:MF_00974} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01687 http://www.ebi.ac.uk/ena/data/view/J01687 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28379 http://www.ebi.ac.uk/ena/data/view/U28379 EMBL V00274 http://www.ebi.ac.uk/ena/data/view/V00274 EMBL V00346 http://www.ebi.ac.uk/ena/data/view/V00346 ENZYME 2.7.7.- {ECO:0000255|HAMAP-Rule:MF_00974} http://enzyme.expasy.org/EC/2.7.7.- {ECO:0000255|HAMAP-Rule:MF_00974} EchoBASE EB0235 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0235 EcoGene EG10239 http://www.ecogene.org/geneInfo.php?eg_id=EG10239 EnsemblBacteria AAC76102 http://www.ensemblgenomes.org/id/AAC76102 EnsemblBacteria AAC76102 http://www.ensemblgenomes.org/id/AAC76102 EnsemblBacteria BAE77117 http://www.ensemblgenomes.org/id/BAE77117 EnsemblBacteria BAE77117 http://www.ensemblgenomes.org/id/BAE77117 EnsemblBacteria BAE77117 http://www.ensemblgenomes.org/id/BAE77117 EnsemblBacteria b3066 http://www.ensemblgenomes.org/id/b3066 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:1990077 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990077 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003896 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003896 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_process GO:0006269 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006269 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 1.10.860.10 http://www.cathdb.info/version/latest/superfamily/1.10.860.10 Gene3D 3.90.580.10 http://www.cathdb.info/version/latest/superfamily/3.90.580.10 Gene3D 3.90.980.10 http://www.cathdb.info/version/latest/superfamily/3.90.980.10 GeneID 947570 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947570 HAMAP MF_00974 http://hamap.expasy.org/unirule/MF_00974 HOGENOM HOG000014483 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000014483&db=HOGENOM6 InParanoid P0ABS5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABS5 IntAct P0ABS5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABS5* IntEnz 2.7.7.- {ECO:0000255|HAMAP-Rule:MF_00974} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.- {ECO:0000255|HAMAP-Rule:MF_00974} InterPro IPR002694 http://www.ebi.ac.uk/interpro/entry/IPR002694 InterPro IPR006171 http://www.ebi.ac.uk/interpro/entry/IPR006171 InterPro IPR006295 http://www.ebi.ac.uk/interpro/entry/IPR006295 InterPro IPR013173 http://www.ebi.ac.uk/interpro/entry/IPR013173 InterPro IPR013264 http://www.ebi.ac.uk/interpro/entry/IPR013264 InterPro IPR016136 http://www.ebi.ac.uk/interpro/entry/IPR016136 InterPro IPR019475 http://www.ebi.ac.uk/interpro/entry/IPR019475 InterPro IPR030846 http://www.ebi.ac.uk/interpro/entry/IPR030846 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03032 http://www.genome.jp/dbget-bin/www_bget?ko03032 KEGG_Gene ecj:JW3038 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3038 KEGG_Gene eco:b3066 http://www.genome.jp/dbget-bin/www_bget?eco:b3066 KEGG_Orthology KO:K02316 http://www.genome.jp/dbget-bin/www_bget?KO:K02316 KEGG_Pathway ko03030 http://www.genome.jp/kegg-bin/show_pathway?ko03030 MINT MINT-1222307 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1222307 OMA EHYRGTK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EHYRGTK PDB 1DD9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1DD9 PDB 1DDE http://www.ebi.ac.uk/pdbe-srv/view/entry/1DDE PDB 1EQN http://www.ebi.ac.uk/pdbe-srv/view/entry/1EQN PDB 1T3W http://www.ebi.ac.uk/pdbe-srv/view/entry/1T3W PDB 2HAJ http://www.ebi.ac.uk/pdbe-srv/view/entry/2HAJ PDB 3B39 http://www.ebi.ac.uk/pdbe-srv/view/entry/3B39 PDBsum 1DD9 http://www.ebi.ac.uk/pdbsum/1DD9 PDBsum 1DDE http://www.ebi.ac.uk/pdbsum/1DDE PDBsum 1EQN http://www.ebi.ac.uk/pdbsum/1EQN PDBsum 1T3W http://www.ebi.ac.uk/pdbsum/1T3W PDBsum 2HAJ http://www.ebi.ac.uk/pdbsum/2HAJ PDBsum 3B39 http://www.ebi.ac.uk/pdbsum/3B39 PROSITE PS50880 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50880 PSORT swissprot:DNAG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DNAG_ECOLI PSORT-B swissprot:DNAG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DNAG_ECOLI PSORT2 swissprot:DNAG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DNAG_ECOLI Pfam PF01807 http://pfam.xfam.org/family/PF01807 Pfam PF08275 http://pfam.xfam.org/family/PF08275 Pfam PF08278 http://pfam.xfam.org/family/PF08278 Pfam PF10410 http://pfam.xfam.org/family/PF10410 Phobius swissprot:DNAG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DNAG_ECOLI PhylomeDB P0ABS5 http://phylomedb.org/?seqid=P0ABS5 ProteinModelPortal P0ABS5 http://www.proteinmodelportal.org/query/uniprot/P0ABS5 PubMed 10741967 http://www.ncbi.nlm.nih.gov/pubmed/10741967 PubMed 10873470 http://www.ncbi.nlm.nih.gov/pubmed/10873470 PubMed 14557266 http://www.ncbi.nlm.nih.gov/pubmed/14557266 PubMed 1511009 http://www.ncbi.nlm.nih.gov/pubmed/1511009 PubMed 15649896 http://www.ncbi.nlm.nih.gov/pubmed/15649896 PubMed 16285921 http://www.ncbi.nlm.nih.gov/pubmed/16285921 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17010164 http://www.ncbi.nlm.nih.gov/pubmed/17010164 PubMed 18193061 http://www.ncbi.nlm.nih.gov/pubmed/18193061 PubMed 340457 http://www.ncbi.nlm.nih.gov/pubmed/340457 PubMed 6186393 http://www.ncbi.nlm.nih.gov/pubmed/6186393 PubMed 6222240 http://www.ncbi.nlm.nih.gov/pubmed/6222240 PubMed 6750604 http://www.ncbi.nlm.nih.gov/pubmed/6750604 PubMed 8679581 http://www.ncbi.nlm.nih.gov/pubmed/8679581 PubMed 8917517 http://www.ncbi.nlm.nih.gov/pubmed/8917517 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417538 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417538 RefSeq WP_000918827 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000918827 SMART SM00400 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00400 SMART SM00493 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00493 SMART SM00766 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00766 SMR P0ABS5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABS5 STRING 511145.b3066 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3066&targetmode=cogs STRING COG0358 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0358&targetmode=cogs TIGRFAMs TIGR01391 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01391 UniProtKB DNAG_ECOLI http://www.uniprot.org/uniprot/DNAG_ECOLI UniProtKB-AC P0ABS5 http://www.uniprot.org/uniprot/P0ABS5 charge swissprot:DNAG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DNAG_ECOLI eggNOG COG0358 http://eggnogapi.embl.de/nog_data/html/tree/COG0358 eggNOG ENOG4105C9G http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C9G epestfind swissprot:DNAG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DNAG_ECOLI garnier swissprot:DNAG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DNAG_ECOLI helixturnhelix swissprot:DNAG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DNAG_ECOLI hmoment swissprot:DNAG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DNAG_ECOLI iep swissprot:DNAG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DNAG_ECOLI inforesidue swissprot:DNAG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DNAG_ECOLI octanol swissprot:DNAG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DNAG_ECOLI pepcoil swissprot:DNAG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DNAG_ECOLI pepdigest swissprot:DNAG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DNAG_ECOLI pepinfo swissprot:DNAG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DNAG_ECOLI pepnet swissprot:DNAG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DNAG_ECOLI pepstats swissprot:DNAG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DNAG_ECOLI pepwheel swissprot:DNAG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DNAG_ECOLI pepwindow swissprot:DNAG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DNAG_ECOLI sigcleave swissprot:DNAG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DNAG_ECOLI ## Database ID URL or Descriptions # AltName ILVB_ECOLI Acetohydroxy-acid synthase I large subunit # BioGrid 4262586 11 # CATALYTIC ACTIVITY ILVB_ECOLI 2 pyruvate = 2-acetolactate + CO(2). # COFACTOR ILVB_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250}; Note=Binds 1 Mg(2+) ion per subunit. {ECO 0000250}; # COFACTOR ILVB_ECOLI Name=thiamine diphosphate; Xref=ChEBI CHEBI 58937; Evidence={ECO 0000250}; Note=Binds 1 thiamine pyrophosphate per subunit. {ECO 0000250}; # EcoGene EG10494 ilvB # GO_component GO:0005948 acetolactate synthase complex; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IEA:InterPro. # GO_function GO:0003984 acetolactate synthase activity; IDA:EcoCyc. # GO_function GO:0030976 thiamine pyrophosphate binding; IEA:InterPro. # GO_function GO:0050660 flavin adenine dinucleotide binding; IEA:InterPro. # GO_process GO:0009097 isoleucine biosynthetic process; IDA:EcoCyc. # GO_process GO:0009099 valine biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.1220 -; 1. # Gene3D 3.40.50.970 -; 2. # IntAct P08142 9 # InterPro IPR000399 TPP-bd_CS # InterPro IPR011766 TPP_enzyme-bd_C # InterPro IPR012000 Thiamin_PyroP_enz_cen_dom # InterPro IPR012001 Thiamin_PyroP_enz_TPP-bd_dom # InterPro IPR012846 Acetolactate_synth_lsu # InterPro IPR029035 DHS-like_NAD/FAD-binding_dom # InterPro IPR029061 THDP-binding # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00290 Valine, leucine and isoleucine biosynthesis # KEGG_Pathway ko00650 Butanoate metabolism # KEGG_Pathway ko00660 C5-Branched dibasic acid metabolism # KEGG_Pathway ko00770 Pantothenate and CoA biosynthesis # MISCELLANEOUS Contains 1 molecule of FAD per monomer. The role of this cofactor is not clear considering that the reaction does not involve redox chemistry (By similarity). {ECO 0000250}. # MISCELLANEOUS E.coli contains genes for 3 AHAS isozymes ilvBN, ilvGM and ilvIH. # Organism ILVB_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-isoleucine biosynthesis; L- isoleucine from 2-oxobutanoate step 1/4. # PATHWAY Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate step 1/4. # PATRIC 32122835 VBIEscCol129921_3793 # PIR A93569 YCEC1L # PROSITE PS00187 TPP_ENZYMES # Pfam PF00205 TPP_enzyme_M # Pfam PF02775 TPP_enzyme_C # Pfam PF02776 TPP_enzyme_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ILVB_ECOLI Acetolactate synthase isozyme 1 large subunit # RefSeq NP_418127 NC_000913.3 # RefSeq WP_000168475 NZ_LN832404.1 # SIMILARITY Belongs to the TPP enzyme family. {ECO 0000305}. # SUBUNIT ILVB_ECOLI Dimer of large and small chains. # SUPFAM SSF52467 SSF52467 # SUPFAM SSF52518 SSF52518; 2 # TIGRFAMs TIGR00118 acolac_lg # UniPathway UPA00047 UER00055 # UniPathway UPA00049 UER00059 # eggNOG COG0028 LUCA # eggNOG ENOG4105C7K Bacteria BLAST swissprot:ILVB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ILVB_ECOLI BioCyc ECOL316407:JW3646-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3646-MONOMER BioCyc EcoCyc:LARGEILVB-MONOMER http://biocyc.org/getid?id=EcoCyc:LARGEILVB-MONOMER BioCyc MetaCyc:LARGEILVB-MONOMER http://biocyc.org/getid?id=MetaCyc:LARGEILVB-MONOMER COG COG0028 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0028 DIP DIP-10019N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10019N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/13.11.3979 http://dx.doi.org/10.1093/nar/13.11.3979 DOI 10.1093/nar/13.11.3995 http://dx.doi.org/10.1093/nar/13.11.3995 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.2.1.6 http://www.genome.jp/dbget-bin/www_bget?EC:2.2.1.6 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X02541 http://www.ebi.ac.uk/ena/data/view/X02541 ENZYME 2.2.1.6 http://enzyme.expasy.org/EC/2.2.1.6 EchoBASE EB0489 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0489 EcoGene EG10494 http://www.ecogene.org/geneInfo.php?eg_id=EG10494 EnsemblBacteria AAC76694 http://www.ensemblgenomes.org/id/AAC76694 EnsemblBacteria AAC76694 http://www.ensemblgenomes.org/id/AAC76694 EnsemblBacteria BAE77622 http://www.ensemblgenomes.org/id/BAE77622 EnsemblBacteria BAE77622 http://www.ensemblgenomes.org/id/BAE77622 EnsemblBacteria BAE77622 http://www.ensemblgenomes.org/id/BAE77622 EnsemblBacteria b3671 http://www.ensemblgenomes.org/id/b3671 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005948 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005948 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0003984 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003984 GO_function GO:0030976 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030976 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_process GO:0009097 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009097 GO_process GO:0009099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009099 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.1220 http://www.cathdb.info/version/latest/superfamily/3.40.50.1220 Gene3D 3.40.50.970 http://www.cathdb.info/version/latest/superfamily/3.40.50.970 GeneID 948182 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948182 HOGENOM HOG000258448 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000258448&db=HOGENOM6 InParanoid P08142 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P08142 IntAct P08142 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P08142* IntEnz 2.2.1.6 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.2.1.6 InterPro IPR000399 http://www.ebi.ac.uk/interpro/entry/IPR000399 InterPro IPR011766 http://www.ebi.ac.uk/interpro/entry/IPR011766 InterPro IPR012000 http://www.ebi.ac.uk/interpro/entry/IPR012000 InterPro IPR012001 http://www.ebi.ac.uk/interpro/entry/IPR012001 InterPro IPR012846 http://www.ebi.ac.uk/interpro/entry/IPR012846 InterPro IPR029035 http://www.ebi.ac.uk/interpro/entry/IPR029035 InterPro IPR029061 http://www.ebi.ac.uk/interpro/entry/IPR029061 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3646 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3646 KEGG_Gene eco:b3671 http://www.genome.jp/dbget-bin/www_bget?eco:b3671 KEGG_Orthology KO:K01652 http://www.genome.jp/dbget-bin/www_bget?KO:K01652 KEGG_Pathway ko00290 http://www.genome.jp/kegg-bin/show_pathway?ko00290 KEGG_Pathway ko00650 http://www.genome.jp/kegg-bin/show_pathway?ko00650 KEGG_Pathway ko00660 http://www.genome.jp/kegg-bin/show_pathway?ko00660 KEGG_Pathway ko00770 http://www.genome.jp/kegg-bin/show_pathway?ko00770 KEGG_Reaction rn:R00006 http://www.genome.jp/dbget-bin/www_bget?rn:R00006 KEGG_Reaction rn:R00014 http://www.genome.jp/dbget-bin/www_bget?rn:R00014 KEGG_Reaction rn:R00226 http://www.genome.jp/dbget-bin/www_bget?rn:R00226 KEGG_Reaction rn:R03050 http://www.genome.jp/dbget-bin/www_bget?rn:R03050 KEGG_Reaction rn:R04672 http://www.genome.jp/dbget-bin/www_bget?rn:R04672 KEGG_Reaction rn:R04673 http://www.genome.jp/dbget-bin/www_bget?rn:R04673 MINT MINT-1243593 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1243593 OMA NIDMIGD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NIDMIGD PROSITE PS00187 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00187 PSORT swissprot:ILVB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ILVB_ECOLI PSORT-B swissprot:ILVB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ILVB_ECOLI PSORT2 swissprot:ILVB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ILVB_ECOLI Pfam PF00205 http://pfam.xfam.org/family/PF00205 Pfam PF02775 http://pfam.xfam.org/family/PF02775 Pfam PF02776 http://pfam.xfam.org/family/PF02776 Phobius swissprot:ILVB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ILVB_ECOLI PhylomeDB P08142 http://phylomedb.org/?seqid=P08142 ProteinModelPortal P08142 http://www.proteinmodelportal.org/query/uniprot/P08142 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2989781 http://www.ncbi.nlm.nih.gov/pubmed/2989781 PubMed 2989782 http://www.ncbi.nlm.nih.gov/pubmed/2989782 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_418127 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418127 RefSeq WP_000168475 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000168475 SMR P08142 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P08142 STRING 511145.b3671 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3671&targetmode=cogs STRING COG0028 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0028&targetmode=cogs SUPFAM SSF52467 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52467 SUPFAM SSF52518 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52518 SWISS-2DPAGE P08142 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P08142 TIGRFAMs TIGR00118 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00118 UniProtKB ILVB_ECOLI http://www.uniprot.org/uniprot/ILVB_ECOLI UniProtKB-AC P08142 http://www.uniprot.org/uniprot/P08142 charge swissprot:ILVB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ILVB_ECOLI eggNOG COG0028 http://eggnogapi.embl.de/nog_data/html/tree/COG0028 eggNOG ENOG4105C7K http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C7K epestfind swissprot:ILVB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ILVB_ECOLI garnier swissprot:ILVB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ILVB_ECOLI helixturnhelix swissprot:ILVB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ILVB_ECOLI hmoment swissprot:ILVB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ILVB_ECOLI iep swissprot:ILVB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ILVB_ECOLI inforesidue swissprot:ILVB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ILVB_ECOLI octanol swissprot:ILVB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ILVB_ECOLI pepcoil swissprot:ILVB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ILVB_ECOLI pepdigest swissprot:ILVB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ILVB_ECOLI pepinfo swissprot:ILVB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ILVB_ECOLI pepnet swissprot:ILVB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ILVB_ECOLI pepstats swissprot:ILVB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ILVB_ECOLI pepwheel swissprot:ILVB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ILVB_ECOLI pepwindow swissprot:ILVB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ILVB_ECOLI sigcleave swissprot:ILVB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ILVB_ECOLI ## Database ID URL or Descriptions # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG11992 yehH # FUNCTION MOLR_ECOLI Was originally thought to be involved in the regulation of molybdate metabolism (PubMed 2156810), has also been implicated in selenate reduction (PubMed 12480890). {ECO 0000269|PubMed 12480890, ECO 0000269|PubMed 2156810}. # Gene3D 2.20.140.10 -; 1. # IntAct P33345 8 # InterPro IPR008893 WGR_domain # InterPro IPR025406 DUF4132 # Organism MOLR_ECOLI Escherichia coli (strain K12) # Pfam PF05406 WGR # Pfam PF13569 DUF4132 # Proteomes UP000000625 Chromosome # RecName MOLR_ECOLI Putative molybdate metabolism regulator # SEQUENCE CAUTION Sequence=AAA60477.1; Type=Frameshift; Positions=275, 950; Evidence={ECO:0000305}; Sequence=U00096; Type=Frameshift; Positions=275, 950; Evidence={ECO 0000305}; # SIMILARITY To E.coli YehI. {ECO 0000305}. # SMART SM00773 WGR # SUPFAM SSF142921 SSF142921 BLAST swissprot:MOLR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MOLR_ECOLI BioCyc EcoCyc:EG11992-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11992-MONOMER BioCyc EcoCyc:G8208-MONOMER http://biocyc.org/getid?id=EcoCyc:G8208-MONOMER BioCyc EcoCyc:G8209-MONOMER http://biocyc.org/getid?id=EcoCyc:G8209-MONOMER DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1935 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1935 EcoGene EG11992 http://www.ecogene.org/geneInfo.php?eg_id=EG11992 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 2.20.140.10 http://www.cathdb.info/version/latest/superfamily/2.20.140.10 HOGENOM HOG000122164 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122164&db=HOGENOM6 IntAct P33345 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33345* InterPro IPR008893 http://www.ebi.ac.uk/interpro/entry/IPR008893 InterPro IPR025406 http://www.ebi.ac.uk/interpro/entry/IPR025406 PSORT swissprot:MOLR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MOLR_ECOLI PSORT-B swissprot:MOLR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MOLR_ECOLI PSORT2 swissprot:MOLR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MOLR_ECOLI Pfam PF05406 http://pfam.xfam.org/family/PF05406 Pfam PF13569 http://pfam.xfam.org/family/PF13569 Phobius swissprot:MOLR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MOLR_ECOLI ProteinModelPortal P33345 http://www.proteinmodelportal.org/query/uniprot/P33345 PubMed 12480890 http://www.ncbi.nlm.nih.gov/pubmed/12480890 PubMed 2156810 http://www.ncbi.nlm.nih.gov/pubmed/2156810 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SMART SM00773 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00773 SUPFAM SSF142921 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF142921 UniProtKB MOLR_ECOLI http://www.uniprot.org/uniprot/MOLR_ECOLI UniProtKB-AC P33345 http://www.uniprot.org/uniprot/P33345 charge swissprot:MOLR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MOLR_ECOLI epestfind swissprot:MOLR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MOLR_ECOLI garnier swissprot:MOLR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MOLR_ECOLI helixturnhelix swissprot:MOLR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MOLR_ECOLI hmoment swissprot:MOLR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MOLR_ECOLI iep swissprot:MOLR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MOLR_ECOLI inforesidue swissprot:MOLR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MOLR_ECOLI octanol swissprot:MOLR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MOLR_ECOLI pepcoil swissprot:MOLR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MOLR_ECOLI pepdigest swissprot:MOLR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MOLR_ECOLI pepinfo swissprot:MOLR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MOLR_ECOLI pepnet swissprot:MOLR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MOLR_ECOLI pepstats swissprot:MOLR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MOLR_ECOLI pepwheel swissprot:MOLR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MOLR_ECOLI pepwindow swissprot:MOLR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MOLR_ECOLI sigcleave swissprot:MOLR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MOLR_ECOLI ## Database ID URL or Descriptions # BioGrid 4261638 326 # DISRUPTION PHENOTYPE Mutants show inhibition of cell division, formation of long, nonseptate filaments, ultimate cessation of growth and lysis. {ECO:0000269|PubMed 1332942}. # DOMAIN FTSL_ECOLI The cytoplasmic region is involved in recruitment of the downstream cell division protein FtsW. The transmembrane segment and the membrane-proximal periplasmic region form a coiled-coil structure and are required for septal localization and interaction with FtsB. The C-terminal region is required for interaction with FtsQ. Contains a leucine zipper-like (LZ) motif, which is required for optimal interaction with FtsB. {ECO 0000269|PubMed 20363951, ECO 0000269|PubMed 21784946}. # EcoGene EG11086 ftsL # FUNCTION FTSL_ECOLI Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. Can also mediate Zn(2+)-sensitivity probably by increasing the permeability of the inner membrane. {ECO 0000255|HAMAP-Rule MF_00910, ECO 0000269|PubMed 10613870, ECO 0000269|PubMed 19233928, ECO 0000269|PubMed 21708137}. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0032153 cell division site; IDA:EcoCyc. # GO_process GO:0043093 FtsZ-dependent cytokinesis; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0008150 biological_process # HAMAP MF_00910 FtsL # INTERACTION FTSL_ECOLI P56976 blr; NbExp=3; IntAct=EBI-1119082, EBI-6419495; P0A6S5 ftsB; NbExp=18; IntAct=EBI-1119082, EBI-1113953; P0AD68 ftsI; NbExp=4; IntAct=EBI-1119082, EBI-548564; P06136 ftsQ; NbExp=11; IntAct=EBI-1119082, EBI-1130157; P58034 ymgF; NbExp=3; IntAct=EBI-1119082, EBI-1214577; # IntAct P0AEN4 17 # InterPro IPR011922 Cell_div_FtsL # KEGG_Brite ko03036 Chromosome # Organism FTSL_ECOLI Escherichia coli (strain K12) # PATRIC 32115271 VBIEscCol129921_0087 # PIR A45278 A45278 # Pfam PF04999 FtsL # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Cell division protein FtsL {ECO:0000255|HAMAP-Rule MF_00910} # RefSeq NP_414625 NC_000913.3 # RefSeq WP_000625658 NZ_LN832404.1 # SIMILARITY Belongs to the FtsL family. {ECO:0000255|HAMAP- Rule MF_00910}. # SUBCELLULAR LOCATION FTSL_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_00910, ECO 0000269|PubMed 10027987, ECO 0000269|PubMed 11703663, ECO 0000269|PubMed 11948172, ECO 0000269|PubMed 1332942, ECO 0000269|PubMed 15165235}; Single- pass type II membrane protein {ECO 0000255|HAMAP-Rule MF_00910, ECO 0000269|PubMed 10027987, ECO 0000269|PubMed 11703663, ECO 0000269|PubMed 11948172, ECO 0000269|PubMed 1332942, ECO 0000269|PubMed 15165235}. Note=Localizes to the division septum where it forms a ring structure. Localization requires FtsZ, FtsA, ZipA, FtsK, FtsQ and FtsB, but not FtsI and FtsN. Localization of FtsB and FtsL is codependent. # SUBUNIT FTSL_ECOLI Part of a complex composed of FtsB, FtsL and FtsQ. The complex can be formed before its localization to the division site. This tripartite complex can be divided further into a subcomplex of FtsB and FtsL, which forms in the absence of FtsQ. Interacts also with FtsI, FtsN and YmgF. Homodimer in vitro. May form multimers. {ECO 0000255|HAMAP-Rule MF_00910, ECO 0000269|PubMed 10613870, ECO 0000269|PubMed 15165235, ECO 0000269|PubMed 15774864, ECO 0000269|PubMed 19233928, ECO 0000269|PubMed 20363951}. # TIGRFAMs TIGR02209 ftsL_broad # eggNOG COG3116 LUCA # eggNOG ENOG41063Y6 Bacteria BLAST swissprot:FTSL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FTSL_ECOLI BioCyc ECOL316407:JW0081-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0081-MONOMER BioCyc EcoCyc:EG11086-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11086-MONOMER COG COG3116 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3116 DIP DIP-47987N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47987N DOI 10.1007/BF00330881 http://dx.doi.org/10.1007/BF00330881 DOI 10.1016/j.bbrc.2011.06.083 http://dx.doi.org/10.1016/j.bbrc.2011.06.083 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1999.01213.x http://dx.doi.org/10.1046/j.1365-2958.1999.01213.x DOI 10.1046/j.1365-2958.2001.02640.x http://dx.doi.org/10.1046/j.1365-2958.2001.02640.x DOI 10.1093/nar/18.9.2813 http://dx.doi.org/10.1093/nar/18.9.2813 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1111/j.1365-2958.2004.04044.x http://dx.doi.org/10.1111/j.1365-2958.2004.04044.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00324-11 http://dx.doi.org/10.1128/JB.00324-11 DOI 10.1128/JB.01597-08 http://dx.doi.org/10.1128/JB.01597-08 DOI 10.1128/JB.01609-09 http://dx.doi.org/10.1128/JB.01609-09 DOI 10.1128/JB.182.1.116-129.2000 http://dx.doi.org/10.1128/JB.182.1.116-129.2000 DOI 10.1128/JB.184.9.2552-2556.2002 http://dx.doi.org/10.1128/JB.184.9.2552-2556.2002 DOI 10.1128/JB.187.7.2233-2243.2005 http://dx.doi.org/10.1128/JB.187.7.2233-2243.2005 DOI 10.1186/1472-6807-11-28 http://dx.doi.org/10.1186/1472-6807-11-28 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K00137 http://www.ebi.ac.uk/ena/data/view/K00137 EMBL S49802 http://www.ebi.ac.uk/ena/data/view/S49802 EMBL S49875 http://www.ebi.ac.uk/ena/data/view/S49875 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X52063 http://www.ebi.ac.uk/ena/data/view/X52063 EMBL X55034 http://www.ebi.ac.uk/ena/data/view/X55034 EchoBASE EB1078 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1078 EcoGene EG11086 http://www.ecogene.org/geneInfo.php?eg_id=EG11086 EnsemblBacteria AAC73194 http://www.ensemblgenomes.org/id/AAC73194 EnsemblBacteria AAC73194 http://www.ensemblgenomes.org/id/AAC73194 EnsemblBacteria BAB96651 http://www.ensemblgenomes.org/id/BAB96651 EnsemblBacteria BAB96651 http://www.ensemblgenomes.org/id/BAB96651 EnsemblBacteria BAB96651 http://www.ensemblgenomes.org/id/BAB96651 EnsemblBacteria b0083 http://www.ensemblgenomes.org/id/b0083 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0032153 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032153 GO_process GO:0043093 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043093 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 944803 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944803 HAMAP MF_00910 http://hamap.expasy.org/unirule/MF_00910 HOGENOM HOG000255861 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000255861&db=HOGENOM6 InParanoid P0AEN4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEN4 IntAct P0AEN4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEN4* InterPro IPR011922 http://www.ebi.ac.uk/interpro/entry/IPR011922 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene ecj:JW0081 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0081 KEGG_Gene eco:b0083 http://www.genome.jp/dbget-bin/www_bget?eco:b0083 KEGG_Orthology KO:K03586 http://www.genome.jp/dbget-bin/www_bget?KO:K03586 MINT MINT-1031895 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1031895 OMA VWITHQT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VWITHQT PSORT swissprot:FTSL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FTSL_ECOLI PSORT-B swissprot:FTSL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FTSL_ECOLI PSORT2 swissprot:FTSL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FTSL_ECOLI Pfam PF04999 http://pfam.xfam.org/family/PF04999 Phobius swissprot:FTSL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FTSL_ECOLI ProteinModelPortal P0AEN4 http://www.proteinmodelportal.org/query/uniprot/P0AEN4 PubMed 10027987 http://www.ncbi.nlm.nih.gov/pubmed/10027987 PubMed 10613870 http://www.ncbi.nlm.nih.gov/pubmed/10613870 PubMed 11703663 http://www.ncbi.nlm.nih.gov/pubmed/11703663 PubMed 11948172 http://www.ncbi.nlm.nih.gov/pubmed/11948172 PubMed 1332942 http://www.ncbi.nlm.nih.gov/pubmed/1332942 PubMed 1447153 http://www.ncbi.nlm.nih.gov/pubmed/1447153 PubMed 15165235 http://www.ncbi.nlm.nih.gov/pubmed/15165235 PubMed 15774864 http://www.ncbi.nlm.nih.gov/pubmed/15774864 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19233928 http://www.ncbi.nlm.nih.gov/pubmed/19233928 PubMed 20363951 http://www.ncbi.nlm.nih.gov/pubmed/20363951 PubMed 21672257 http://www.ncbi.nlm.nih.gov/pubmed/21672257 PubMed 21708137 http://www.ncbi.nlm.nih.gov/pubmed/21708137 PubMed 21784946 http://www.ncbi.nlm.nih.gov/pubmed/21784946 PubMed 2187182 http://www.ncbi.nlm.nih.gov/pubmed/2187182 PubMed 6350821 http://www.ncbi.nlm.nih.gov/pubmed/6350821 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414625 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414625 RefSeq WP_000625658 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000625658 STRING 511145.b0083 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0083&targetmode=cogs STRING COG3116 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3116&targetmode=cogs TIGRFAMs TIGR02209 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02209 UniProtKB FTSL_ECOLI http://www.uniprot.org/uniprot/FTSL_ECOLI UniProtKB-AC P0AEN4 http://www.uniprot.org/uniprot/P0AEN4 charge swissprot:FTSL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FTSL_ECOLI eggNOG COG3116 http://eggnogapi.embl.de/nog_data/html/tree/COG3116 eggNOG ENOG41063Y6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41063Y6 epestfind swissprot:FTSL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FTSL_ECOLI garnier swissprot:FTSL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FTSL_ECOLI helixturnhelix swissprot:FTSL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FTSL_ECOLI hmoment swissprot:FTSL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FTSL_ECOLI iep swissprot:FTSL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FTSL_ECOLI inforesidue swissprot:FTSL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FTSL_ECOLI octanol swissprot:FTSL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FTSL_ECOLI pepcoil swissprot:FTSL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FTSL_ECOLI pepdigest swissprot:FTSL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FTSL_ECOLI pepinfo swissprot:FTSL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FTSL_ECOLI pepnet swissprot:FTSL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FTSL_ECOLI pepstats swissprot:FTSL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FTSL_ECOLI pepwheel swissprot:FTSL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FTSL_ECOLI pepwindow swissprot:FTSL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FTSL_ECOLI sigcleave swissprot:FTSL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FTSL_ECOLI ## Database ID URL or Descriptions # AltName CHBF_ECOLI Cellobiose-6-phosphate hydrolase # AltName CHBF_ECOLI Phospho-chitobiase # BRENDA 3.2.1.86 2026 # BioGrid 4259132 396 # CATALYTIC ACTIVITY CHBF_ECOLI 6-phospho-beta-D-glucosyl-(1,4)-D-glucose + H(2)O = D-glucose + D-glucose 6-phosphate. # CAUTION Was originally (PubMed:2179047) characterized as part of a cryptic cel operon for a cellobiose degradation system. The Cel+ phenotype is due to mutations making expression chitobiose- independent and altering the substrate specificity. {ECO 0000305|PubMed:2179047}. # CAZy GH4 Glycoside Hydrolase Family 4 # COFACTOR CHBF_ECOLI Name=Mn(2+); Xref=ChEBI CHEBI 29035; Name=Co(2+); Xref=ChEBI CHEBI 48828; Name=Ni(2+); Xref=ChEBI CHEBI 49786; Note=Divalent metal ion. Manganese, cobalt and nickel ions enhance activity whereas magnesium, calcium, strontium and zinc ions do not.; # COFACTOR Name=NAD(+); Xref=ChEBI:CHEBI 57540; # EcoGene EG10144 chbF # FUNCTION CHBF_ECOLI Hydrolyzes a wide variety of P-beta-glucosides including cellobiose-6P, salicin-6P, arbutin-6P, gentiobiose-6P, methyl- beta-glucoside-6P and p-nitrophenyl-beta-D-glucopyranoside-6P. Is also able to hydrolyze phospho-N,N'-diacetylchitobiose. {ECO 0000269|PubMed 10913117}. # GO_function GO:0008706 6-phospho-beta-glucosidase activity; IDA:EcoCyc. # GO_function GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0005975 carbohydrate metabolic process; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # Gene3D 3.40.50.720 -; 1. # Gene3D 3.90.110.10 -; 1. # INDUCTION CHBF_ECOLI By N,N'-diacetylchitobiose. # IntAct P17411 4 # InterPro IPR001088 Glyco_hydro_4 # InterPro IPR015955 Lactate_DH/Glyco_Ohase_4_C # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR019802 GlycHydrolase_4_CS # InterPro IPR022616 Glyco_hydro_4_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00010 Glycolysis / Gluconeogenesis # MASS SPECTROMETRY Mass=50386; Method=Electrospray; Range=2-450; Evidence={ECO:0000269|PubMed 10572139}; # Organism CHBF_ECOLI Escherichia coli (strain K12) # PATRIC 32118777 VBIEscCol129921_1806 # PIR F64932 F64932 # PRINTS PR00732 GLHYDRLASE4 # PROSITE PS01324 GLYCOSYL_HYDROL_F4 # Pfam PF02056 Glyco_hydro_4 # Pfam PF11975 Glyco_hydro_4C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CHBF_ECOLI 6-phospho-beta-glucosidase # RefSeq NP_416248 NC_000913.3 # RefSeq WP_000078765 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA37073.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=CAA47257.1; Type=Frameshift; Positions=Several; Evidence={ECO 0000305}; Sequence=CAA47259.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; # SIMILARITY Belongs to the glycosyl hydrolase 4 family. {ECO 0000305}. # SUBUNIT CHBF_ECOLI Homotetramer. # SUPFAM SSF51735 SSF51735 # SUPFAM SSF56327 SSF56327 # eggNOG COG1486 LUCA # eggNOG ENOG4105F8D Bacteria BLAST swissprot:CHBF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CHBF_ECOLI BioCyc ECOL316407:JW1723-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1723-MONOMER BioCyc EcoCyc:EG10144-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10144-MONOMER BioCyc MetaCyc:EG10144-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10144-MONOMER COG COG1486 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1486 DOI 10.1007/BF00281796 http://dx.doi.org/10.1007/BF00281796 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.94.26.14367 http://dx.doi.org/10.1073/pnas.94.26.14367 DOI 10.1074/jbc.M001043200 http://dx.doi.org/10.1074/jbc.M001043200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.2.1.86 http://www.genome.jp/dbget-bin/www_bget?EC:3.2.1.86 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X52890 http://www.ebi.ac.uk/ena/data/view/X52890 EMBL X66725 http://www.ebi.ac.uk/ena/data/view/X66725 EMBL X66725 http://www.ebi.ac.uk/ena/data/view/X66725 ENZYME 3.2.1.86 http://enzyme.expasy.org/EC/3.2.1.86 EchoBASE EB0142 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0142 EcoGene EG10144 http://www.ecogene.org/geneInfo.php?eg_id=EG10144 EnsemblBacteria AAC74804 http://www.ensemblgenomes.org/id/AAC74804 EnsemblBacteria AAC74804 http://www.ensemblgenomes.org/id/AAC74804 EnsemblBacteria BAA15515 http://www.ensemblgenomes.org/id/BAA15515 EnsemblBacteria BAA15515 http://www.ensemblgenomes.org/id/BAA15515 EnsemblBacteria BAA15515 http://www.ensemblgenomes.org/id/BAA15515 EnsemblBacteria b1734 http://www.ensemblgenomes.org/id/b1734 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008706 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008706 GO_function GO:0016616 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016616 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 Gene3D 3.90.110.10 http://www.cathdb.info/version/latest/superfamily/3.90.110.10 GeneID 946266 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946266 HOGENOM HOG000239811 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000239811&db=HOGENOM6 InParanoid P17411 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P17411 IntAct P17411 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P17411* IntEnz 3.2.1.86 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.2.1.86 InterPro IPR001088 http://www.ebi.ac.uk/interpro/entry/IPR001088 InterPro IPR015955 http://www.ebi.ac.uk/interpro/entry/IPR015955 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR019802 http://www.ebi.ac.uk/interpro/entry/IPR019802 InterPro IPR022616 http://www.ebi.ac.uk/interpro/entry/IPR022616 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1723 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1723 KEGG_Gene eco:b1734 http://www.genome.jp/dbget-bin/www_bget?eco:b1734 KEGG_Orthology KO:K01222 http://www.genome.jp/dbget-bin/www_bget?KO:K01222 KEGG_Pathway ko00010 http://www.genome.jp/kegg-bin/show_pathway?ko00010 KEGG_Reaction rn:R05133 http://www.genome.jp/dbget-bin/www_bget?rn:R05133 OMA CNVPINF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CNVPINF PRINTS PR00732 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00732 PROSITE PS01324 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01324 PSORT swissprot:CHBF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CHBF_ECOLI PSORT-B swissprot:CHBF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CHBF_ECOLI PSORT2 swissprot:CHBF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CHBF_ECOLI Pfam PF02056 http://pfam.xfam.org/family/PF02056 Pfam PF11975 http://pfam.xfam.org/family/PF11975 Phobius swissprot:CHBF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CHBF_ECOLI PhylomeDB P17411 http://phylomedb.org/?seqid=P17411 ProteinModelPortal P17411 http://www.proteinmodelportal.org/query/uniprot/P17411 PubMed 10572139 http://www.ncbi.nlm.nih.gov/pubmed/10572139 PubMed 10913117 http://www.ncbi.nlm.nih.gov/pubmed/10913117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2179047 http://www.ncbi.nlm.nih.gov/pubmed/2179047 PubMed 8121401 http://www.ncbi.nlm.nih.gov/pubmed/8121401 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9405618 http://www.ncbi.nlm.nih.gov/pubmed/9405618 RefSeq NP_416248 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416248 RefSeq WP_000078765 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000078765 SMR P17411 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P17411 STRING 511145.b1734 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1734&targetmode=cogs STRING COG1486 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1486&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 SUPFAM SSF56327 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56327 UniProtKB CHBF_ECOLI http://www.uniprot.org/uniprot/CHBF_ECOLI UniProtKB-AC P17411 http://www.uniprot.org/uniprot/P17411 charge swissprot:CHBF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CHBF_ECOLI eggNOG COG1486 http://eggnogapi.embl.de/nog_data/html/tree/COG1486 eggNOG ENOG4105F8D http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F8D epestfind swissprot:CHBF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CHBF_ECOLI garnier swissprot:CHBF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CHBF_ECOLI helixturnhelix swissprot:CHBF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CHBF_ECOLI hmoment swissprot:CHBF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CHBF_ECOLI iep swissprot:CHBF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CHBF_ECOLI inforesidue swissprot:CHBF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CHBF_ECOLI octanol swissprot:CHBF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CHBF_ECOLI pepcoil swissprot:CHBF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CHBF_ECOLI pepdigest swissprot:CHBF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CHBF_ECOLI pepinfo swissprot:CHBF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CHBF_ECOLI pepnet swissprot:CHBF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CHBF_ECOLI pepstats swissprot:CHBF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CHBF_ECOLI pepwheel swissprot:CHBF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CHBF_ECOLI pepwindow swissprot:CHBF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CHBF_ECOLI sigcleave swissprot:CHBF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CHBF_ECOLI ## Database ID URL or Descriptions # BioGrid 4260626 159 # EcoGene EG13204 yfjR # GO_component GO:0005622 intracellular; IEA:InterPro. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:1900190 regulation of single-species biofilm formation; IMP:EcoCyc. # GOslim_component GO:0005622 intracellular # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # IntAct P52133 3 # InterPro IPR001034 DeoR_HTH # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR018356 Tscrpt_reg_HTH_DeoR_CS # InterPro IPR026881 WYL_dom # Organism YFJR_ECOLI Escherichia coli (strain K12) # PATRIC 32120659 VBIEscCol129921_2728 # PIR T08646 T08646 # PROSITE PS00894 HTH_DEOR_1 # PROSITE PS51000 HTH_DEOR_2 # Pfam PF08220 HTH_DeoR # Pfam PF13280 WYL # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFJR_ECOLI Uncharacterized HTH-type transcriptional regulator YfjR # RefSeq NP_417123 NC_000913.3 # RefSeq WP_000189409 NZ_LN832404.1 # SIMILARITY Contains 1 HTH deoR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00349}. # eggNOG COG2378 LUCA # eggNOG ENOG4108KZE Bacteria BLAST swissprot:YFJR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFJR_ECOLI BioCyc ECOL316407:JW2615-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2615-MONOMER BioCyc EcoCyc:G7369-MONOMER http://biocyc.org/getid?id=EcoCyc:G7369-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36840 http://www.ebi.ac.uk/ena/data/view/U36840 EchoBASE EB2996 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2996 EcoGene EG13204 http://www.ecogene.org/geneInfo.php?eg_id=EG13204 EnsemblBacteria AAC75682 http://www.ensemblgenomes.org/id/AAC75682 EnsemblBacteria AAC75682 http://www.ensemblgenomes.org/id/AAC75682 EnsemblBacteria BAE76769 http://www.ensemblgenomes.org/id/BAE76769 EnsemblBacteria BAE76769 http://www.ensemblgenomes.org/id/BAE76769 EnsemblBacteria BAE76769 http://www.ensemblgenomes.org/id/BAE76769 EnsemblBacteria b2634 http://www.ensemblgenomes.org/id/b2634 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:1900190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1900190 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 947309 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947309 HOGENOM HOG000124724 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000124724&db=HOGENOM6 IntAct P52133 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P52133* InterPro IPR001034 http://www.ebi.ac.uk/interpro/entry/IPR001034 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR018356 http://www.ebi.ac.uk/interpro/entry/IPR018356 InterPro IPR026881 http://www.ebi.ac.uk/interpro/entry/IPR026881 KEGG_Gene ecj:JW2615 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2615 KEGG_Gene eco:b2634 http://www.genome.jp/dbget-bin/www_bget?eco:b2634 OMA SPCLIWH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SPCLIWH PROSITE PS00894 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00894 PROSITE PS51000 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51000 PSORT swissprot:YFJR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFJR_ECOLI PSORT-B swissprot:YFJR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFJR_ECOLI PSORT2 swissprot:YFJR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFJR_ECOLI Pfam PF08220 http://pfam.xfam.org/family/PF08220 Pfam PF13280 http://pfam.xfam.org/family/PF13280 Phobius swissprot:YFJR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFJR_ECOLI ProteinModelPortal P52133 http://www.proteinmodelportal.org/query/uniprot/P52133 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417123 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417123 RefSeq WP_000189409 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000189409 STRING 511145.b2634 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2634&targetmode=cogs UniProtKB YFJR_ECOLI http://www.uniprot.org/uniprot/YFJR_ECOLI UniProtKB-AC P52133 http://www.uniprot.org/uniprot/P52133 charge swissprot:YFJR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFJR_ECOLI eggNOG COG2378 http://eggnogapi.embl.de/nog_data/html/tree/COG2378 eggNOG ENOG4108KZE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108KZE epestfind swissprot:YFJR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFJR_ECOLI garnier swissprot:YFJR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFJR_ECOLI helixturnhelix swissprot:YFJR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFJR_ECOLI hmoment swissprot:YFJR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFJR_ECOLI iep swissprot:YFJR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFJR_ECOLI inforesidue swissprot:YFJR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFJR_ECOLI octanol swissprot:YFJR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFJR_ECOLI pepcoil swissprot:YFJR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFJR_ECOLI pepdigest swissprot:YFJR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFJR_ECOLI pepinfo swissprot:YFJR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFJR_ECOLI pepnet swissprot:YFJR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFJR_ECOLI pepstats swissprot:YFJR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFJR_ECOLI pepwheel swissprot:YFJR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFJR_ECOLI pepwindow swissprot:YFJR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFJR_ECOLI sigcleave swissprot:YFJR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFJR_ECOLI ## Database ID URL or Descriptions # BioGrid 4261345 7 # EcoGene EG12485 yjfJ # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # IntAct P0AF78 3 # InterPro IPR007157 PspA_IM30 # Organism YJFJ_ECOLI Escherichia coli (strain K12) # PATRIC 32123939 VBIEscCol129921_4314 # PIR S56407 S56407 # Pfam PF04012 PspA_IM30 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJFJ_ECOLI Uncharacterized protein YjfJ # RefSeq NP_418603 NC_000913.3 # RefSeq WP_000511955 NZ_LN832404.1 # SIMILARITY Belongs to the PspA/IM30 family. {ECO 0000305}. # eggNOG COG1842 LUCA # eggNOG ENOG4108P9J Bacteria BLAST swissprot:YJFJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJFJ_ECOLI BioCyc ECOL316407:JW4140-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4140-MONOMER BioCyc EcoCyc:G7847-MONOMER http://biocyc.org/getid?id=EcoCyc:G7847-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2378 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2378 EcoGene EG12485 http://www.ecogene.org/geneInfo.php?eg_id=EG12485 EnsemblBacteria AAC77139 http://www.ensemblgenomes.org/id/AAC77139 EnsemblBacteria AAC77139 http://www.ensemblgenomes.org/id/AAC77139 EnsemblBacteria BAE78183 http://www.ensemblgenomes.org/id/BAE78183 EnsemblBacteria BAE78183 http://www.ensemblgenomes.org/id/BAE78183 EnsemblBacteria BAE78183 http://www.ensemblgenomes.org/id/BAE78183 EnsemblBacteria b4182 http://www.ensemblgenomes.org/id/b4182 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GeneID 948703 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948703 HOGENOM HOG000287984 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000287984&db=HOGENOM6 InParanoid P0AF78 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AF78 IntAct P0AF78 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AF78* InterPro IPR007157 http://www.ebi.ac.uk/interpro/entry/IPR007157 KEGG_Gene ecj:JW4140 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4140 KEGG_Gene eco:b4182 http://www.genome.jp/dbget-bin/www_bget?eco:b4182 OMA HLTKAKR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HLTKAKR PSORT swissprot:YJFJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJFJ_ECOLI PSORT-B swissprot:YJFJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJFJ_ECOLI PSORT2 swissprot:YJFJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJFJ_ECOLI Pfam PF04012 http://pfam.xfam.org/family/PF04012 Phobius swissprot:YJFJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJFJ_ECOLI PhylomeDB P0AF78 http://phylomedb.org/?seqid=P0AF78 ProteinModelPortal P0AF78 http://www.proteinmodelportal.org/query/uniprot/P0AF78 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418603 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418603 RefSeq WP_000511955 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000511955 SMR P0AF78 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AF78 STRING 511145.b4182 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4182&targetmode=cogs UniProtKB YJFJ_ECOLI http://www.uniprot.org/uniprot/YJFJ_ECOLI UniProtKB-AC P0AF78 http://www.uniprot.org/uniprot/P0AF78 charge swissprot:YJFJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJFJ_ECOLI eggNOG COG1842 http://eggnogapi.embl.de/nog_data/html/tree/COG1842 eggNOG ENOG4108P9J http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108P9J epestfind swissprot:YJFJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJFJ_ECOLI garnier swissprot:YJFJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJFJ_ECOLI helixturnhelix swissprot:YJFJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJFJ_ECOLI hmoment swissprot:YJFJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJFJ_ECOLI iep swissprot:YJFJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJFJ_ECOLI inforesidue swissprot:YJFJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJFJ_ECOLI octanol swissprot:YJFJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJFJ_ECOLI pepcoil swissprot:YJFJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJFJ_ECOLI pepdigest swissprot:YJFJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJFJ_ECOLI pepinfo swissprot:YJFJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJFJ_ECOLI pepnet swissprot:YJFJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJFJ_ECOLI pepstats swissprot:YJFJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJFJ_ECOLI pepwheel swissprot:YJFJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJFJ_ECOLI pepwindow swissprot:YJFJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJFJ_ECOLI sigcleave swissprot:YJFJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJFJ_ECOLI ## Database ID URL or Descriptions # AltName GCVR_ECOLI Gcv operon repressor # BioGrid 4260580 8 # EcoGene EG11149 gcvR # FUNCTION GCVR_ECOLI Negative transcriptional regulator of the glycine cleavage system operon (GCV). Does not autoregulate its own expression. It is not yet known how GcvR acts as a repressor. It does not seem to bind DNA. It could interact with GcvA and suppress its activatory activity. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0016597 amino acid binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # IntAct P0A9I3 3 # InterPro IPR002912 ACT_dom # InterPro IPR016867 GcvR # KEGG_Brite ko03000 Transcription factors # Organism GCVR_ECOLI Escherichia coli (strain K12) # PATRIC 32120345 VBIEscCol129921_2575 # PIRSF PIRSF028103 GcvR # PROSITE PS51671 ACT; 2 # Pfam PF01842 ACT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GCVR_ECOLI Glycine cleavage system transcriptional repressor # RefSeq NP_416974 NC_000913.3 # RefSeq WP_000176187 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB88561.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Contains 2 ACT domains. {ECO:0000255|PROSITE- ProRule PRU01007}. # SUBCELLULAR LOCATION GCVR_ECOLI Cytoplasm. # eggNOG COG2716 LUCA # eggNOG ENOG4105RH4 Bacteria BLAST swissprot:GCVR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GCVR_ECOLI BioCyc ECOL316407:JW2464-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2464-MONOMER BioCyc EcoCyc:EG11149-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11149-MONOMER COG COG2716 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2716 DIP DIP-9754N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9754N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1099/00221287-137-2-361 http://dx.doi.org/10.1099/00221287-137-2-361 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AF023337 http://www.ebi.ac.uk/ena/data/view/AF023337 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M63654 http://www.ebi.ac.uk/ena/data/view/M63654 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1138 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1138 EcoGene EG11149 http://www.ecogene.org/geneInfo.php?eg_id=EG11149 EnsemblBacteria AAC75532 http://www.ensemblgenomes.org/id/AAC75532 EnsemblBacteria AAC75532 http://www.ensemblgenomes.org/id/AAC75532 EnsemblBacteria BAA16356 http://www.ensemblgenomes.org/id/BAA16356 EnsemblBacteria BAA16356 http://www.ensemblgenomes.org/id/BAA16356 EnsemblBacteria BAA16356 http://www.ensemblgenomes.org/id/BAA16356 EnsemblBacteria b2479 http://www.ensemblgenomes.org/id/b2479 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0016597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016597 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 946950 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946950 HOGENOM HOG000272598 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000272598&db=HOGENOM6 InParanoid P0A9I3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9I3 IntAct P0A9I3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9I3* InterPro IPR002912 http://www.ebi.ac.uk/interpro/entry/IPR002912 InterPro IPR016867 http://www.ebi.ac.uk/interpro/entry/IPR016867 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW2464 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2464 KEGG_Gene eco:b2479 http://www.genome.jp/dbget-bin/www_bget?eco:b2479 KEGG_Orthology KO:K03567 http://www.genome.jp/dbget-bin/www_bget?KO:K03567 OMA DLITIMK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DLITIMK PROSITE PS51671 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51671 PSORT swissprot:GCVR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GCVR_ECOLI PSORT-B swissprot:GCVR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GCVR_ECOLI PSORT2 swissprot:GCVR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GCVR_ECOLI Pfam PF01842 http://pfam.xfam.org/family/PF01842 Phobius swissprot:GCVR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GCVR_ECOLI PhylomeDB P0A9I3 http://phylomedb.org/?seqid=P0A9I3 ProteinModelPortal P0A9I3 http://www.proteinmodelportal.org/query/uniprot/P0A9I3 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2016588 http://www.ncbi.nlm.nih.gov/pubmed/2016588 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9537378 http://www.ncbi.nlm.nih.gov/pubmed/9537378 RefSeq NP_416974 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416974 RefSeq WP_000176187 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000176187 SMR P0A9I3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9I3 STRING 511145.b2479 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2479&targetmode=cogs STRING COG2716 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2716&targetmode=cogs UniProtKB GCVR_ECOLI http://www.uniprot.org/uniprot/GCVR_ECOLI UniProtKB-AC P0A9I3 http://www.uniprot.org/uniprot/P0A9I3 charge swissprot:GCVR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GCVR_ECOLI eggNOG COG2716 http://eggnogapi.embl.de/nog_data/html/tree/COG2716 eggNOG ENOG4105RH4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105RH4 epestfind swissprot:GCVR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GCVR_ECOLI garnier swissprot:GCVR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GCVR_ECOLI helixturnhelix swissprot:GCVR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GCVR_ECOLI hmoment swissprot:GCVR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GCVR_ECOLI iep swissprot:GCVR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GCVR_ECOLI inforesidue swissprot:GCVR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GCVR_ECOLI octanol swissprot:GCVR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GCVR_ECOLI pepcoil swissprot:GCVR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GCVR_ECOLI pepdigest swissprot:GCVR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GCVR_ECOLI pepinfo swissprot:GCVR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GCVR_ECOLI pepnet swissprot:GCVR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GCVR_ECOLI pepstats swissprot:GCVR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GCVR_ECOLI pepwheel swissprot:GCVR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GCVR_ECOLI pepwindow swissprot:GCVR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GCVR_ECOLI sigcleave swissprot:GCVR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GCVR_ECOLI ## Database ID URL or Descriptions # AltName LDCA_ECOLI LD-carboxypeptidase A # AltName LDCA_ECOLI Muramoyltetrapeptide carboxypeptidase # BioGrid 4259643 325 # CATALYTIC ACTIVITY GlcNAc-MurNAc-L-alanyl-gamma-D-glutamyl-meso- diaminopimelyl-D-alanine + H(2)O = GlcNAc-MurNAc-L-alanyl-gamma-D- glutamyl-meso-diaminopimelate + D-alanine. {ECO:0000269|PubMed 10428950}. # DISRUPTION PHENOTYPE Bacteriolysis during the stationary growth phase. Cells lacking this gene also accumulate UDP-MurNAc- tetrapeptide, an unusual compound that normally is not present at significant levels in E.coli cells. {ECO:0000269|PubMed 10428950}. # ENZYME REGULATION Inhibited by beta-lactams containing a D-amino acid side chain. {ECO:0000269|PubMed 10428950}. # EcoGene EG13898 ldcA # FUNCTION LDCA_ECOLI Releases the terminal D-alanine residue from the cytoplasmic tetrapeptide recycling product L-Ala-gamma-D-Glu-meso- Dap-D-Ala. To a lesser extent, can also cleave D-Ala from murein derivatives containing the tetrapeptide, i.e. MurNAc-tetrapeptide, UDP-MurNAc-tetrapeptide, GlcNAc-MurNAc-tetrapeptide, and GlcNAc- anhMurNAc-tetrapeptide. Does not act on murein sacculi or cross- linked muropeptides. The tripeptides produced by the LcdA reaction can then be reused as peptidoglycan building blocks; LcdA is thereby involved in murein recycling. Is also essential for viability during stationary phase. {ECO 0000269|PubMed 10428950, ECO 0000269|PubMed 18535144}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004180 carboxypeptidase activity; IDA:EcoCyc. # GO_function GO:0008236 serine-type peptidase activity; IEA:UniProtKB-KW. # GO_process GO:0008360 regulation of cell shape; IEA:UniProtKB-KW. # GO_process GO:0009050 glycopeptide catabolic process; IDA:EcoCyc. # GO_process GO:0009252 peptidoglycan biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0009254 peptidoglycan turnover; IGI:EcoCyc. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0008233 peptidase activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 3.40.50.10740 -; 1. # Gene3D 3.50.30.60 -; 1. # IntAct P76008 4 # InterPro IPR003507 S66_fam # InterPro IPR027461 Carboxypeptidase_A_C # InterPro IPR027478 LdcA_N_dom # InterPro IPR029062 Class_I_gatase-like # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # Organism LDCA_ECOLI Escherichia coli (strain K12) # PATHWAY Cell wall biogenesis; peptidoglycan recycling. {ECO:0000269|PubMed 10428950}. # PATRIC 32117632 VBIEscCol129921_1238 # PIR E64865 E64865 # PIRSF PIRSF028757 LD-carboxypeptidase # Pfam PF02016 Peptidase_S66 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LDCA_ECOLI Murein tetrapeptide carboxypeptidase # RefSeq NP_415710 NC_000913.3 # RefSeq WP_000051560 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase S66 family. {ECO 0000305}. # SUBCELLULAR LOCATION LDCA_ECOLI Cytoplasm {ECO 0000269|PubMed 10428950}. # SUPFAM SSF141986 SSF141986 # SUPFAM SSF52317 SSF52317 # eggNOG COG1619 LUCA # eggNOG ENOG4105EBE Bacteria BLAST swissprot:LDCA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LDCA_ECOLI BioCyc ECOL316407:JW1181-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1181-MONOMER BioCyc EcoCyc:G6621-MONOMER http://biocyc.org/getid?id=EcoCyc:G6621-MONOMER BioCyc MetaCyc:G6621-MONOMER http://biocyc.org/getid?id=MetaCyc:G6621-MONOMER COG COG1619 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1619 DIP DIP-10085N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10085N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/emboj/18.15.4108 http://dx.doi.org/10.1093/emboj/18.15.4108 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/MMBR.00027-07 http://dx.doi.org/10.1128/MMBR.00027-07 EC_number EC:3.4.17.13 http://www.genome.jp/dbget-bin/www_bget?EC:3.4.17.13 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.4.17.13 http://enzyme.expasy.org/EC/3.4.17.13 EchoBASE EB3657 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3657 EcoGene EG13898 http://www.ecogene.org/geneInfo.php?eg_id=EG13898 EnsemblBacteria AAC74276 http://www.ensemblgenomes.org/id/AAC74276 EnsemblBacteria AAC74276 http://www.ensemblgenomes.org/id/AAC74276 EnsemblBacteria BAA36050 http://www.ensemblgenomes.org/id/BAA36050 EnsemblBacteria BAA36050 http://www.ensemblgenomes.org/id/BAA36050 EnsemblBacteria BAA36050 http://www.ensemblgenomes.org/id/BAA36050 EnsemblBacteria b1192 http://www.ensemblgenomes.org/id/b1192 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004180 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004180 GO_function GO:0008236 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008236 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0009050 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009050 GO_process GO:0009252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009252 GO_process GO:0009254 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009254 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 3.40.50.10740 http://www.cathdb.info/version/latest/superfamily/3.40.50.10740 Gene3D 3.50.30.60 http://www.cathdb.info/version/latest/superfamily/3.50.30.60 GeneID 945756 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945756 HOGENOM HOG000025480 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000025480&db=HOGENOM6 InParanoid P76008 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76008 IntAct P76008 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76008* IntEnz 3.4.17.13 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.17.13 InterPro IPR003507 http://www.ebi.ac.uk/interpro/entry/IPR003507 InterPro IPR027461 http://www.ebi.ac.uk/interpro/entry/IPR027461 InterPro IPR027478 http://www.ebi.ac.uk/interpro/entry/IPR027478 InterPro IPR029062 http://www.ebi.ac.uk/interpro/entry/IPR029062 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW1181 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1181 KEGG_Gene eco:b1192 http://www.genome.jp/dbget-bin/www_bget?eco:b1192 KEGG_Orthology KO:K01297 http://www.genome.jp/dbget-bin/www_bget?KO:K01297 OMA IVGHSDF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IVGHSDF PSORT swissprot:LDCA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LDCA_ECOLI PSORT-B swissprot:LDCA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LDCA_ECOLI PSORT2 swissprot:LDCA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LDCA_ECOLI Pfam PF02016 http://pfam.xfam.org/family/PF02016 Phobius swissprot:LDCA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LDCA_ECOLI PhylomeDB P76008 http://phylomedb.org/?seqid=P76008 ProteinModelPortal P76008 http://www.proteinmodelportal.org/query/uniprot/P76008 PubMed 10428950 http://www.ncbi.nlm.nih.gov/pubmed/10428950 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18535144 http://www.ncbi.nlm.nih.gov/pubmed/18535144 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415710 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415710 RefSeq WP_000051560 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000051560 SMR P76008 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76008 STRING 511145.b1192 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1192&targetmode=cogs STRING COG1619 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1619&targetmode=cogs SUPFAM SSF141986 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF141986 SUPFAM SSF52317 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52317 UniProtKB LDCA_ECOLI http://www.uniprot.org/uniprot/LDCA_ECOLI UniProtKB-AC P76008 http://www.uniprot.org/uniprot/P76008 charge swissprot:LDCA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LDCA_ECOLI eggNOG COG1619 http://eggnogapi.embl.de/nog_data/html/tree/COG1619 eggNOG ENOG4105EBE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EBE epestfind swissprot:LDCA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LDCA_ECOLI garnier swissprot:LDCA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LDCA_ECOLI helixturnhelix swissprot:LDCA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LDCA_ECOLI hmoment swissprot:LDCA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LDCA_ECOLI iep swissprot:LDCA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LDCA_ECOLI inforesidue swissprot:LDCA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LDCA_ECOLI octanol swissprot:LDCA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LDCA_ECOLI pepcoil swissprot:LDCA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LDCA_ECOLI pepdigest swissprot:LDCA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LDCA_ECOLI pepinfo swissprot:LDCA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LDCA_ECOLI pepnet swissprot:LDCA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LDCA_ECOLI pepstats swissprot:LDCA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LDCA_ECOLI pepwheel swissprot:LDCA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LDCA_ECOLI pepwindow swissprot:LDCA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LDCA_ECOLI sigcleave swissprot:LDCA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LDCA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259428 18 # CATALYTIC ACTIVITY ASCB_ECOLI 6-phospho-beta-D-glucosyl-(1,4)-D-glucose + H(2)O = D-glucose + D-glucose 6-phosphate. # CAZy GH1 Glycoside Hydrolase Family 1 # EcoGene EG10085 ascB # FUNCTION ASCB_ECOLI Can hydrolyze salicin, cellobiose, and probably arbutin. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0008422 beta-glucosidase activity; IBA:GO_Central. # GO_function GO:0008706 6-phospho-beta-glucosidase activity; IEA:UniProtKB-EC. # GO_process GO:0044724 single-organism carbohydrate catabolic process; IBA:GO_Central. # GO_process GO:1901657 glycosyl compound metabolic process; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # Gene3D 3.20.20.80 -; 1. # IntAct P24240 5 # InterPro IPR001360 Glyco_hydro_1 # InterPro IPR013781 Glyco_hydro_catalytic_dom # InterPro IPR017853 Glycoside_hydrolase_SF # InterPro IPR018120 Glyco_hydro_1_AS # InterPro IPR033132 Glyco_hydro_1_N_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00010 Glycolysis / Gluconeogenesis # Organism ASCB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10353 PTHR10353 # PATRIC 32120832 VBIEscCol129921_2808 # PIR H65051 H65051 # PRINTS PR00131 GLHYDRLASE1 # PROSITE PS00572 GLYCOSYL_HYDROL_F1_1 # PROSITE PS00653 GLYCOSYL_HYDROL_F1_2 # Pfam PF00232 Glyco_hydro_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ASCB_ECOLI 6-phospho-beta-glucosidase AscB # RefSeq NP_417196 NC_000913.3 # RefSeq WP_000110363 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA69226.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the glycosyl hydrolase 1 family. {ECO 0000305}. # SUPFAM SSF51445 SSF51445 # eggNOG COG2723 LUCA # eggNOG ENOG4105CS2 Bacteria BLAST swissprot:ASCB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ASCB_ECOLI BioCyc ECOL316407:JW2686-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2686-MONOMER BioCyc EcoCyc:EG10085-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10085-MONOMER BioCyc MetaCyc:EG10085-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10085-MONOMER COG COG2723 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2723 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.2.1.86 http://www.genome.jp/dbget-bin/www_bget?EC:3.2.1.86 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M73326 http://www.ebi.ac.uk/ena/data/view/M73326 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 ENZYME 3.2.1.86 http://enzyme.expasy.org/EC/3.2.1.86 EchoBASE EB0083 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0083 EcoGene EG10085 http://www.ecogene.org/geneInfo.php?eg_id=EG10085 EnsemblBacteria AAC75758 http://www.ensemblgenomes.org/id/AAC75758 EnsemblBacteria AAC75758 http://www.ensemblgenomes.org/id/AAC75758 EnsemblBacteria BAE76793 http://www.ensemblgenomes.org/id/BAE76793 EnsemblBacteria BAE76793 http://www.ensemblgenomes.org/id/BAE76793 EnsemblBacteria BAE76793 http://www.ensemblgenomes.org/id/BAE76793 EnsemblBacteria b2716 http://www.ensemblgenomes.org/id/b2716 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008422 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008422 GO_function GO:0008706 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008706 GO_process GO:0044724 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044724 GO_process GO:1901657 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901657 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 3.20.20.80 http://www.cathdb.info/version/latest/superfamily/3.20.20.80 GeneID 947460 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947460 HOGENOM HOG000088631 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000088631&db=HOGENOM6 InParanoid P24240 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P24240 IntAct P24240 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P24240* IntEnz 3.2.1.86 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.2.1.86 InterPro IPR001360 http://www.ebi.ac.uk/interpro/entry/IPR001360 InterPro IPR013781 http://www.ebi.ac.uk/interpro/entry/IPR013781 InterPro IPR017853 http://www.ebi.ac.uk/interpro/entry/IPR017853 InterPro IPR018120 http://www.ebi.ac.uk/interpro/entry/IPR018120 InterPro IPR033132 http://www.ebi.ac.uk/interpro/entry/IPR033132 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2686 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2686 KEGG_Gene eco:b2716 http://www.genome.jp/dbget-bin/www_bget?eco:b2716 KEGG_Orthology KO:K01223 http://www.genome.jp/dbget-bin/www_bget?KO:K01223 KEGG_Pathway ko00010 http://www.genome.jp/kegg-bin/show_pathway?ko00010 KEGG_Reaction rn:R05134 http://www.genome.jp/dbget-bin/www_bget?rn:R05134 OMA GAYPAYT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GAYPAYT PANTHER PTHR10353 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10353 PRINTS PR00131 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00131 PROSITE PS00572 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00572 PROSITE PS00653 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00653 PSORT swissprot:ASCB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ASCB_ECOLI PSORT-B swissprot:ASCB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ASCB_ECOLI PSORT2 swissprot:ASCB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ASCB_ECOLI Pfam PF00232 http://pfam.xfam.org/family/PF00232 Phobius swissprot:ASCB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ASCB_ECOLI PhylomeDB P24240 http://phylomedb.org/?seqid=P24240 ProteinModelPortal P24240 http://www.proteinmodelportal.org/query/uniprot/P24240 PubMed 1630307 http://www.ncbi.nlm.nih.gov/pubmed/1630307 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417196 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417196 RefSeq WP_000110363 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000110363 SMR P24240 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P24240 STRING 511145.b2716 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2716&targetmode=cogs STRING COG2723 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2723&targetmode=cogs SUPFAM SSF51445 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51445 UniProtKB ASCB_ECOLI http://www.uniprot.org/uniprot/ASCB_ECOLI UniProtKB-AC P24240 http://www.uniprot.org/uniprot/P24240 charge swissprot:ASCB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ASCB_ECOLI eggNOG COG2723 http://eggnogapi.embl.de/nog_data/html/tree/COG2723 eggNOG ENOG4105CS2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CS2 epestfind swissprot:ASCB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ASCB_ECOLI garnier swissprot:ASCB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ASCB_ECOLI helixturnhelix swissprot:ASCB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ASCB_ECOLI hmoment swissprot:ASCB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ASCB_ECOLI iep swissprot:ASCB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ASCB_ECOLI inforesidue swissprot:ASCB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ASCB_ECOLI octanol swissprot:ASCB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ASCB_ECOLI pepcoil swissprot:ASCB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ASCB_ECOLI pepdigest swissprot:ASCB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ASCB_ECOLI pepinfo swissprot:ASCB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ASCB_ECOLI pepnet swissprot:ASCB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ASCB_ECOLI pepstats swissprot:ASCB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ASCB_ECOLI pepwheel swissprot:ASCB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ASCB_ECOLI pepwindow swissprot:ASCB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ASCB_ECOLI sigcleave swissprot:ASCB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ASCB_ECOLI ## Database ID URL or Descriptions # AltName 5-(carboxyamino)imidazole ribonucleotide synthetase {ECO:0000255|HAMAP-Rule MF_01928, ECO:0000305} # BRENDA 6.3.4.18 2026 # BioGrid 4259875 16 # CATALYTIC ACTIVITY PURK_ECOLI ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO(3)(-) = ADP + phosphate + 5-carboxyamino-1-(5-phospho-D- ribosyl)imidazole. {ECO 0000255|HAMAP-Rule MF_01928, ECO 0000269|PubMed 8117684}. # CAUTION Was originally thought to be the ATPase subunit of phosphoribosylaminoimidazole carboxylase, with catalytic subunit PurE. {ECO:0000305|PubMed 2464576}. # EcoGene EG10796 purK # FUNCTION PURK_ECOLI Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR). {ECO 0000255|HAMAP-Rule MF_01928, ECO 0000269|PubMed 8117684}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004638 phosphoribosylaminoimidazole carboxylase activity; IDA:EcoliWiki. # GO_function GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity; IBA:GO_Central. # GO_function GO:0005524 ATP binding; IDA:EcoCyc. # GO_function GO:0034028 5-(carboxyamino)imidazole ribonucleotide synthase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:InterPro. # GO_process GO:0006189 'de novo' IMP biosynthetic process; IBA:GO_Central. # GO_process GO:0046084 adenine biosynthetic process; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.30.470.20 -; 1. # Gene3D 3.40.50.20 -; 1. # HAMAP MF_01928 PurK # IntAct P09029 5 # InterPro IPR003135 ATP-grasp_carboxylate-amine # InterPro IPR005875 PurK # InterPro IPR011054 Rudment_hybrid_motif # InterPro IPR011761 ATP-grasp # InterPro IPR013816 ATP_grasp_subdomain_2 # InterPro IPR016185 PreATP-grasp_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # Organism PURK_ECOLI Escherichia coli (strain K12) # PATHWAY PURK_ECOLI Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5- amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route) step 1/2. {ECO 0000255|HAMAP-Rule MF_01928, ECO 0000269|PubMed 8117684}. # PATRIC 32116204 VBIEscCol129921_0543 # PDB 1B6R X-ray; 2.10 A; A=1-355 # PDB 1B6S X-ray; 2.50 A; A/B/C/D=1-355 # PDB 3ETH X-ray; 1.60 A; A/B=1-355 # PDB 3ETJ X-ray; 1.60 A; A/B=1-355 # PIR JU0001 DCECPK # PROSITE PS50975 ATP_GRASP # Pfam PF02222 ATP-grasp # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName N5-carboxyaminoimidazole ribonucleotide synthase {ECO:0000255|HAMAP-Rule MF_01928, ECO:0000305} # RefSeq NP_415055 NC_000913.3 # RefSeq WP_000815571 NZ_LN832404.1 # SIMILARITY Belongs to the PurK/PurT family. {ECO:0000255|HAMAP- Rule MF_01928, ECO:0000305}. # SIMILARITY Contains 1 ATP-grasp domain. {ECO:0000255|HAMAP- Rule MF_01928}. # SUBUNIT PURK_ECOLI Homodimer. {ECO 0000255|HAMAP-Rule MF_01928, ECO 0000269|PubMed 10569930, ECO 0000269|PubMed 19053251}. # SUPFAM SSF51246 SSF51246 # SUPFAM SSF52440 SSF52440 # TIGRFAMs TIGR01161 purK # UniPathway UPA00074 UER00942 # eggNOG COG0026 LUCA # eggNOG ENOG4105CY8 Bacteria BLAST swissprot:PURK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PURK_ECOLI BioCyc ECOL316407:JW0511-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0511-MONOMER BioCyc EcoCyc:PURK-MONOMER http://biocyc.org/getid?id=EcoCyc:PURK-MONOMER BioCyc MetaCyc:PURK-MONOMER http://biocyc.org/getid?id=MetaCyc:PURK-MONOMER COG COG0026 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0026 DOI 10.1021/bi00136a016 http://dx.doi.org/10.1021/bi00136a016 DOI 10.1021/bi00174a038 http://dx.doi.org/10.1021/bi00174a038 DOI 10.1021/bi801734z http://dx.doi.org/10.1021/bi801734z DOI 10.1021/bi991618s http://dx.doi.org/10.1021/bi991618s DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.3.4.18 {ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:8117684} http://www.genome.jp/dbget-bin/www_bget?EC:6.3.4.18 {ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:8117684} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M19657 http://www.ebi.ac.uk/ena/data/view/M19657 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL X12982 http://www.ebi.ac.uk/ena/data/view/X12982 ENZYME 6.3.4.18 {ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:8117684} http://enzyme.expasy.org/EC/6.3.4.18 {ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:8117684} EchoBASE EB0789 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0789 EcoGene EG10796 http://www.ecogene.org/geneInfo.php?eg_id=EG10796 EnsemblBacteria AAC73624 http://www.ensemblgenomes.org/id/AAC73624 EnsemblBacteria AAC73624 http://www.ensemblgenomes.org/id/AAC73624 EnsemblBacteria BAE76299 http://www.ensemblgenomes.org/id/BAE76299 EnsemblBacteria BAE76299 http://www.ensemblgenomes.org/id/BAE76299 EnsemblBacteria BAE76299 http://www.ensemblgenomes.org/id/BAE76299 EnsemblBacteria b0522 http://www.ensemblgenomes.org/id/b0522 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004638 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004638 GO_function GO:0004639 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004639 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0034028 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034028 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006189 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006189 GO_process GO:0046084 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046084 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.30.470.20 http://www.cathdb.info/version/latest/superfamily/3.30.470.20 Gene3D 3.40.50.20 http://www.cathdb.info/version/latest/superfamily/3.40.50.20 GeneID 945153 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945153 HAMAP MF_01928 http://hamap.expasy.org/unirule/MF_01928 HOGENOM HOG000034026 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000034026&db=HOGENOM6 InParanoid P09029 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P09029 IntAct P09029 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P09029* IntEnz 6.3.4.18 {ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:8117684} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.4.18 {ECO:0000255|HAMAP-Rule:MF_01928, ECO:0000269|PubMed:8117684} InterPro IPR003135 http://www.ebi.ac.uk/interpro/entry/IPR003135 InterPro IPR005875 http://www.ebi.ac.uk/interpro/entry/IPR005875 InterPro IPR011054 http://www.ebi.ac.uk/interpro/entry/IPR011054 InterPro IPR011761 http://www.ebi.ac.uk/interpro/entry/IPR011761 InterPro IPR013816 http://www.ebi.ac.uk/interpro/entry/IPR013816 InterPro IPR016185 http://www.ebi.ac.uk/interpro/entry/IPR016185 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0511 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0511 KEGG_Gene eco:b0522 http://www.genome.jp/dbget-bin/www_bget?eco:b0522 KEGG_Orthology KO:K01589 http://www.genome.jp/dbget-bin/www_bget?KO:K01589 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Reaction rn:R07404 http://www.genome.jp/dbget-bin/www_bget?rn:R07404 OMA CHIHWYG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CHIHWYG PDB 1B6R http://www.ebi.ac.uk/pdbe-srv/view/entry/1B6R PDB 1B6S http://www.ebi.ac.uk/pdbe-srv/view/entry/1B6S PDB 3ETH http://www.ebi.ac.uk/pdbe-srv/view/entry/3ETH PDB 3ETJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3ETJ PDBsum 1B6R http://www.ebi.ac.uk/pdbsum/1B6R PDBsum 1B6S http://www.ebi.ac.uk/pdbsum/1B6S PDBsum 3ETH http://www.ebi.ac.uk/pdbsum/3ETH PDBsum 3ETJ http://www.ebi.ac.uk/pdbsum/3ETJ PROSITE PS50975 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50975 PSORT swissprot:PURK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PURK_ECOLI PSORT-B swissprot:PURK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PURK_ECOLI PSORT2 swissprot:PURK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PURK_ECOLI Pfam PF02222 http://pfam.xfam.org/family/PF02222 Phobius swissprot:PURK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PURK_ECOLI PhylomeDB P09029 http://phylomedb.org/?seqid=P09029 ProteinModelPortal P09029 http://www.proteinmodelportal.org/query/uniprot/P09029 PubMed 10569930 http://www.ncbi.nlm.nih.gov/pubmed/10569930 PubMed 1534690 http://www.ncbi.nlm.nih.gov/pubmed/1534690 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19053251 http://www.ncbi.nlm.nih.gov/pubmed/19053251 PubMed 2464576 http://www.ncbi.nlm.nih.gov/pubmed/2464576 PubMed 2644189 http://www.ncbi.nlm.nih.gov/pubmed/2644189 PubMed 8117684 http://www.ncbi.nlm.nih.gov/pubmed/8117684 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415055 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415055 RefSeq WP_000815571 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000815571 SMR P09029 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P09029 STRING 511145.b0522 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0522&targetmode=cogs STRING COG0026 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0026&targetmode=cogs SUPFAM SSF51246 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51246 SUPFAM SSF52440 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52440 SWISS-2DPAGE P09029 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P09029 TIGRFAMs TIGR01161 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01161 UniProtKB PURK_ECOLI http://www.uniprot.org/uniprot/PURK_ECOLI UniProtKB-AC P09029 http://www.uniprot.org/uniprot/P09029 charge swissprot:PURK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PURK_ECOLI eggNOG COG0026 http://eggnogapi.embl.de/nog_data/html/tree/COG0026 eggNOG ENOG4105CY8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CY8 epestfind swissprot:PURK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PURK_ECOLI garnier swissprot:PURK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PURK_ECOLI helixturnhelix swissprot:PURK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PURK_ECOLI hmoment swissprot:PURK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PURK_ECOLI iep swissprot:PURK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PURK_ECOLI inforesidue swissprot:PURK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PURK_ECOLI octanol swissprot:PURK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PURK_ECOLI pepcoil swissprot:PURK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PURK_ECOLI pepdigest swissprot:PURK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PURK_ECOLI pepinfo swissprot:PURK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PURK_ECOLI pepnet swissprot:PURK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PURK_ECOLI pepstats swissprot:PURK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PURK_ECOLI pepwheel swissprot:PURK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PURK_ECOLI pepwindow swissprot:PURK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PURK_ECOLI sigcleave swissprot:PURK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PURK_ECOLI ## Database ID URL or Descriptions # AltName NFRA_ECOLI Bacteriophage N4 adsorption protein A # BioGrid 4259890 192 # EcoGene EG11740 nfrA # FUNCTION NFRA_ECOLI (Microbial infection) Allows N4 phage attachment by binding to the viral non-contractile sheath protein. {ECO 0000269|PubMed 19011026}. # GO_component GO:0009279 cell outer membrane; IEA:UniProtKB-SubCell. # GOslim_component GO:0005575 cellular_component # Gene3D 1.25.40.10 -; 3. # IntAct P31600 10 # InterPro IPR011990 TPR-like_helical_dom # InterPro IPR013026 TPR-contain_dom # InterPro IPR019734 TPR_repeat # InterPro IPR025137 NfrA_C # Organism NFRA_ECOLI Escherichia coli (strain K12) # PATRIC 32116304 VBIEscCol129921_0592 # PIR B49351 B49351 # PROSITE PS50005 TPR; 3 # PROSITE PS50293 TPR_REGION # Pfam PF13283 NfrA_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Bacteriophage adsorption protein A {ECO 0000305} # RefSeq NP_415100 NC_000913.3 # RefSeq WP_000662357 NZ_LN832404.1 # SIMILARITY Contains 3 TPR repeats. {ECO:0000255|PROSITE- ProRule PRU00339}. # SMART SM00028 TPR; 2 # SUBCELLULAR LOCATION NFRA_ECOLI Cell outer membrane. # SUBUNIT (Microbial infection) Interacts with N4 phage non- contractile sheath protein; this interaction is essential for viral adsorption to the host. {ECO:0000269|PubMed 19011026}. # SUPFAM SSF48452 SSF48452; 4 # eggNOG COG0457 LUCA # eggNOG ENOG41090FC Bacteria BLAST swissprot:NFRA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NFRA_ECOLI BioCyc ECOL316407:JW0557-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0557-MONOMER BioCyc EcoCyc:EG11740-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11740-MONOMER COG COG0457 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0457 DIP DIP-10332N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10332N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01423-08 http://dx.doi.org/10.1128/JB.01423-08 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L16945 http://www.ebi.ac.uk/ena/data/view/L16945 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB1691 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1691 EcoGene EG11740 http://www.ecogene.org/geneInfo.php?eg_id=EG11740 EnsemblBacteria AAC73669 http://www.ensemblgenomes.org/id/AAC73669 EnsemblBacteria AAC73669 http://www.ensemblgenomes.org/id/AAC73669 EnsemblBacteria BAA35202 http://www.ensemblgenomes.org/id/BAA35202 EnsemblBacteria BAA35202 http://www.ensemblgenomes.org/id/BAA35202 EnsemblBacteria BAA35202 http://www.ensemblgenomes.org/id/BAA35202 EnsemblBacteria b0568 http://www.ensemblgenomes.org/id/b0568 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 Gene3D 1.25.40.10 http://www.cathdb.info/version/latest/superfamily/1.25.40.10 GeneID 944741 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944741 HOGENOM HOG000117813 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117813&db=HOGENOM6 IntAct P31600 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31600* InterPro IPR011990 http://www.ebi.ac.uk/interpro/entry/IPR011990 InterPro IPR013026 http://www.ebi.ac.uk/interpro/entry/IPR013026 InterPro IPR019734 http://www.ebi.ac.uk/interpro/entry/IPR019734 InterPro IPR025137 http://www.ebi.ac.uk/interpro/entry/IPR025137 KEGG_Gene ecj:JW0557 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0557 KEGG_Gene eco:b0568 http://www.genome.jp/dbget-bin/www_bget?eco:b0568 KEGG_Orthology KO:K11739 http://www.genome.jp/dbget-bin/www_bget?KO:K11739 OMA WTGESHY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WTGESHY PROSITE PS50005 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50005 PROSITE PS50293 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50293 PSORT swissprot:NFRA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NFRA_ECOLI PSORT-B swissprot:NFRA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NFRA_ECOLI PSORT2 swissprot:NFRA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NFRA_ECOLI Pfam PF13283 http://pfam.xfam.org/family/PF13283 Phobius swissprot:NFRA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NFRA_ECOLI ProteinModelPortal P31600 http://www.proteinmodelportal.org/query/uniprot/P31600 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19011026 http://www.ncbi.nlm.nih.gov/pubmed/19011026 PubMed 8226649 http://www.ncbi.nlm.nih.gov/pubmed/8226649 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415100 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415100 RefSeq WP_000662357 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000662357 SMART SM00028 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00028 STRING 511145.b0568 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0568&targetmode=cogs STRING COG0457 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0457&targetmode=cogs SUPFAM SSF48452 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48452 UniProtKB NFRA_ECOLI http://www.uniprot.org/uniprot/NFRA_ECOLI UniProtKB-AC P31600 http://www.uniprot.org/uniprot/P31600 charge swissprot:NFRA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NFRA_ECOLI eggNOG COG0457 http://eggnogapi.embl.de/nog_data/html/tree/COG0457 eggNOG ENOG41090FC http://eggnogapi.embl.de/nog_data/html/tree/ENOG41090FC epestfind swissprot:NFRA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NFRA_ECOLI garnier swissprot:NFRA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NFRA_ECOLI helixturnhelix swissprot:NFRA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NFRA_ECOLI hmoment swissprot:NFRA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NFRA_ECOLI iep swissprot:NFRA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NFRA_ECOLI inforesidue swissprot:NFRA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NFRA_ECOLI octanol swissprot:NFRA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NFRA_ECOLI pepcoil swissprot:NFRA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NFRA_ECOLI pepdigest swissprot:NFRA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NFRA_ECOLI pepinfo swissprot:NFRA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NFRA_ECOLI pepnet swissprot:NFRA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NFRA_ECOLI pepstats swissprot:NFRA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NFRA_ECOLI pepwheel swissprot:NFRA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NFRA_ECOLI pepwindow swissprot:NFRA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NFRA_ECOLI sigcleave swissprot:NFRA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NFRA_ECOLI ## Database ID URL or Descriptions # Organism YUAT_ECOLI Escherichia coli (strain K12) # RecName YUAT_ECOLI Uncharacterized protein YuaT # RefSeq NP_061413 NC_002483.1 # RefSeq WP_010892532 NZ_CP014273.1 BLAST swissprot:YUAT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YUAT_ECOLI EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1263505 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263505 OMA QDIHGAS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QDIHGAS PSORT swissprot:YUAT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YUAT_ECOLI PSORT-B swissprot:YUAT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YUAT_ECOLI PSORT2 swissprot:YUAT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YUAT_ECOLI Phobius swissprot:YUAT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YUAT_ECOLI ProteinModelPortal Q9JMS1 http://www.proteinmodelportal.org/query/uniprot/Q9JMS1 RefSeq NP_061413 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061413 RefSeq WP_010892532 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_010892532 UniProtKB YUAT_ECOLI http://www.uniprot.org/uniprot/YUAT_ECOLI UniProtKB-AC Q9JMS1 http://www.uniprot.org/uniprot/Q9JMS1 charge swissprot:YUAT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YUAT_ECOLI epestfind swissprot:YUAT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YUAT_ECOLI garnier swissprot:YUAT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YUAT_ECOLI helixturnhelix swissprot:YUAT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YUAT_ECOLI hmoment swissprot:YUAT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YUAT_ECOLI iep swissprot:YUAT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YUAT_ECOLI inforesidue swissprot:YUAT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YUAT_ECOLI octanol swissprot:YUAT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YUAT_ECOLI pepcoil swissprot:YUAT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YUAT_ECOLI pepdigest swissprot:YUAT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YUAT_ECOLI pepinfo swissprot:YUAT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YUAT_ECOLI pepnet swissprot:YUAT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YUAT_ECOLI pepstats swissprot:YUAT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YUAT_ECOLI pepwheel swissprot:YUAT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YUAT_ECOLI pepwindow swissprot:YUAT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YUAT_ECOLI sigcleave swissprot:YUAT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YUAT_ECOLI ## Database ID URL or Descriptions # BioGrid 4262869 238 # EcoGene EG13893 ycgL # HAMAP MF_01866 UPF0745 # IntAct P0AB43 37 # InterPro IPR027354 YcgL_dom # Organism YCGL_ECOLI Escherichia coli (strain K12) # PATRIC 32117604 VBIEscCol129921_1224 # PIR H64863 H64863 # PROSITE PS51648 YCGL # Pfam PF05166 YcgL # ProDom PD030374 YcgL_domain # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Protein YcgL {ECO:0000255|HAMAP-Rule MF_01866} # RefSeq NP_415697 NC_000913.3 # RefSeq WP_001125720 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAC74263.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Contains 1 YcgL domain. {ECO:0000255|HAMAP- Rule MF_01866}. # eggNOG COG3100 LUCA # eggNOG ENOG4105VNG Bacteria BLAST swissprot:YCGL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCGL_ECOLI BioCyc ECOL316407:JW1168-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1168-MONOMER BioCyc EcoCyc:G6616-MONOMER http://biocyc.org/getid?id=EcoCyc:G6616-MONOMER COG COG3100 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3100 DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3652 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3652 EcoGene EG13893 http://www.ecogene.org/geneInfo.php?eg_id=EG13893 EnsemblBacteria AAC74263 http://www.ensemblgenomes.org/id/AAC74263 EnsemblBacteria AAC74263 http://www.ensemblgenomes.org/id/AAC74263 EnsemblBacteria BAA36013 http://www.ensemblgenomes.org/id/BAA36013 EnsemblBacteria BAA36013 http://www.ensemblgenomes.org/id/BAA36013 EnsemblBacteria BAA36013 http://www.ensemblgenomes.org/id/BAA36013 EnsemblBacteria b1179 http://www.ensemblgenomes.org/id/b1179 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946226 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946226 HAMAP MF_01866 http://hamap.expasy.org/unirule/MF_01866 HOGENOM HOG000218244 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218244&db=HOGENOM6 InParanoid P0AB43 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AB43 IntAct P0AB43 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AB43* InterPro IPR027354 http://www.ebi.ac.uk/interpro/entry/IPR027354 KEGG_Gene ecj:JW1168 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1168 KEGG_Gene eco:b1179 http://www.genome.jp/dbget-bin/www_bget?eco:b1179 KEGG_Orthology KO:K09902 http://www.genome.jp/dbget-bin/www_bget?KO:K09902 PROSITE PS51648 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51648 PSORT swissprot:YCGL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCGL_ECOLI PSORT-B swissprot:YCGL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCGL_ECOLI PSORT2 swissprot:YCGL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCGL_ECOLI Pfam PF05166 http://pfam.xfam.org/family/PF05166 Phobius swissprot:YCGL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCGL_ECOLI ProteinModelPortal P0AB43 http://www.proteinmodelportal.org/query/uniprot/P0AB43 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415697 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415697 RefSeq WP_001125720 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001125720 SMR P0AB43 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AB43 STRING 511145.b1179 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1179&targetmode=cogs STRING COG3100 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3100&targetmode=cogs UniProtKB YCGL_ECOLI http://www.uniprot.org/uniprot/YCGL_ECOLI UniProtKB-AC P0AB43 http://www.uniprot.org/uniprot/P0AB43 charge swissprot:YCGL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCGL_ECOLI eggNOG COG3100 http://eggnogapi.embl.de/nog_data/html/tree/COG3100 eggNOG ENOG4105VNG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VNG epestfind swissprot:YCGL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCGL_ECOLI garnier swissprot:YCGL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCGL_ECOLI helixturnhelix swissprot:YCGL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCGL_ECOLI hmoment swissprot:YCGL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCGL_ECOLI iep swissprot:YCGL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCGL_ECOLI inforesidue swissprot:YCGL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCGL_ECOLI octanol swissprot:YCGL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCGL_ECOLI pepcoil swissprot:YCGL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCGL_ECOLI pepdigest swissprot:YCGL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCGL_ECOLI pepinfo swissprot:YCGL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCGL_ECOLI pepnet swissprot:YCGL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCGL_ECOLI pepstats swissprot:YCGL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCGL_ECOLI pepwheel swissprot:YCGL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCGL_ECOLI pepwindow swissprot:YCGL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCGL_ECOLI sigcleave swissprot:YCGL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCGL_ECOLI ## Database ID URL or Descriptions # EcoGene EG40005 insE3 # FUNCTION INSE3_ECOLI Involved in the transposition of the insertion sequence IS3. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 1.10.10.60 -; 1. # InterPro IPR002514 Transposase_8 # InterPro IPR009057 Homeodomain-like # Organism INSE3_ECOLI Escherichia coli (strain K12) # PIR A64845 A64845 # Pfam PF01527 HTH_Tnp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSE3_ECOLI Transposase InsE for insertion sequence IS3C # RefSeq NP_061380 NC_002483.1 # RefSeq NP_061395 NC_002483.1 # RefSeq NP_414832 NC_000913.3 # RefSeq NP_414907 NC_000913.3 # RefSeq NP_415072 NC_000913.3 # RefSeq NP_415546 NC_000913.3 # RefSeq NP_416592 NC_000913.3 # RefSeq WP_000169527 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40737.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAE76315.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the transposase 8 family. {ECO 0000305}. # SUPFAM SSF46689 SSF46689 # eggNOG COG2963 LUCA # eggNOG ENOG41090WB Bacteria BLAST swissprot:INSE3_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSE3_ECOLI BioCyc EcoCyc:MONOMER0-4243 http://biocyc.org/getid?id=EcoCyc:MONOMER0-4243 COG COG2963 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2963 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB4715 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4715 EcoGene EG40005 http://www.ecogene.org/geneInfo.php?eg_id=EG40005 EnsemblBacteria AAC73641 http://www.ensemblgenomes.org/id/AAC73641 EnsemblBacteria AAC73641 http://www.ensemblgenomes.org/id/AAC73641 EnsemblBacteria BAE76315 http://www.ensemblgenomes.org/id/BAE76315 EnsemblBacteria BAE76315 http://www.ensemblgenomes.org/id/BAE76315 EnsemblBacteria BAE76315 http://www.ensemblgenomes.org/id/BAE76315 EnsemblBacteria b0540 http://www.ensemblgenomes.org/id/b0540 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 GeneID 1263530 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263530 GeneID 1263552 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263552 GeneID 944952 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944952 GeneID 945584 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945584 GeneID 945759 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945759 GeneID 946616 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946616 GeneID 946900 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946900 HOGENOM HOG000266649 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000266649&db=HOGENOM6 InterPro IPR002514 http://www.ebi.ac.uk/interpro/entry/IPR002514 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 KEGG_Gene ecj:JW5074 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5074 KEGG_Gene eco:b0298 http://www.genome.jp/dbget-bin/www_bget?eco:b0298 KEGG_Gene eco:b0373 http://www.genome.jp/dbget-bin/www_bget?eco:b0373 KEGG_Gene eco:b0540 http://www.genome.jp/dbget-bin/www_bget?eco:b0540 KEGG_Gene eco:b1027 http://www.genome.jp/dbget-bin/www_bget?eco:b1027 KEGG_Gene eco:b2088 http://www.genome.jp/dbget-bin/www_bget?eco:b2088 KEGG_Orthology KO:K07483 http://www.genome.jp/dbget-bin/www_bget?KO:K07483 PSORT swissprot:INSE3_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSE3_ECOLI PSORT-B swissprot:INSE3_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSE3_ECOLI PSORT2 swissprot:INSE3_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSE3_ECOLI Pfam PF01527 http://pfam.xfam.org/family/PF01527 Phobius swissprot:INSE3_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSE3_ECOLI ProteinModelPortal P0CF68 http://www.proteinmodelportal.org/query/uniprot/P0CF68 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_061380 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061380 RefSeq NP_061395 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061395 RefSeq NP_414832 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414832 RefSeq NP_414907 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414907 RefSeq NP_415072 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415072 RefSeq NP_415546 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415546 RefSeq NP_416592 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416592 RefSeq WP_000169527 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000169527 STRING 511145.b2088 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2088&targetmode=cogs STRING COG2963 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2963&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 UniProtKB INSE3_ECOLI http://www.uniprot.org/uniprot/INSE3_ECOLI UniProtKB-AC P0CF68 http://www.uniprot.org/uniprot/P0CF68 charge swissprot:INSE3_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSE3_ECOLI eggNOG COG2963 http://eggnogapi.embl.de/nog_data/html/tree/COG2963 eggNOG ENOG41090WB http://eggnogapi.embl.de/nog_data/html/tree/ENOG41090WB epestfind swissprot:INSE3_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSE3_ECOLI garnier swissprot:INSE3_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSE3_ECOLI helixturnhelix swissprot:INSE3_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSE3_ECOLI hmoment swissprot:INSE3_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSE3_ECOLI iep swissprot:INSE3_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSE3_ECOLI inforesidue swissprot:INSE3_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSE3_ECOLI octanol swissprot:INSE3_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSE3_ECOLI pepcoil swissprot:INSE3_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSE3_ECOLI pepdigest swissprot:INSE3_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSE3_ECOLI pepinfo swissprot:INSE3_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSE3_ECOLI pepnet swissprot:INSE3_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSE3_ECOLI pepstats swissprot:INSE3_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSE3_ECOLI pepwheel swissprot:INSE3_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSE3_ECOLI pepwindow swissprot:INSE3_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSE3_ECOLI sigcleave swissprot:INSE3_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSE3_ECOLI ## Database ID URL or Descriptions # BioGrid 4260933 21 # COFACTOR YGIQ_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000305}; Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. {ECO 0000305}; # EcoGene EG13019 ygiQ # GO_function GO:0003824 catalytic activity; IEA:InterPro. # GO_function GO:0005506 iron ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # Gene3D 3.80.30.20 -; 1. # HAMAP MF_01251 UPF0313 # InterPro IPR006638 Elp3/MiaB/NifB # InterPro IPR007197 rSAM # InterPro IPR013704 UPF0313_N # InterPro IPR020612 Methylthiotransferase_CS # InterPro IPR022946 UPF0313 # InterPro IPR023404 rSAM_horseshoe # InterPro IPR024560 UPF0313_C # Organism YGIQ_ECOLI Escherichia coli (strain K12) # PATRIC 32121446 VBIEscCol129921_3110 # Pfam PF04055 Radical_SAM # Pfam PF08497 Radical_SAM_N # Pfam PF11842 DUF3362 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGIQ_ECOLI UPF0313 protein YgiQ # RefSeq WP_000095187 NZ_LN832404.1 # RefSeq YP_026196 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA69183.1; Type=Frameshift; Positions=321; Evidence={ECO:0000305}; Sequence=AAA69184.1; Type=Frameshift; Positions=321; Evidence={ECO 0000305}; # SIMILARITY Belongs to the UPF0313 family. {ECO 0000305}. # SMART SM00729 Elp3 # TIGRFAMs TIGR03904 SAM_YgiQ # eggNOG COG1032 LUCA # eggNOG ENOG4105CCT Bacteria BLAST swissprot:YGIQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGIQ_ECOLI BioCyc ECOL316407:JW5501-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5501-MONOMER BioCyc EcoCyc:G7568-MONOMER http://biocyc.org/getid?id=EcoCyc:G7568-MONOMER DIP DIP-12224N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12224N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2838 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2838 EcoGene EG13019 http://www.ecogene.org/geneInfo.php?eg_id=EG13019 EnsemblBacteria AAT48161 http://www.ensemblgenomes.org/id/AAT48161 EnsemblBacteria AAT48161 http://www.ensemblgenomes.org/id/AAT48161 EnsemblBacteria BAE77072 http://www.ensemblgenomes.org/id/BAE77072 EnsemblBacteria BAE77072 http://www.ensemblgenomes.org/id/BAE77072 EnsemblBacteria BAE77072 http://www.ensemblgenomes.org/id/BAE77072 EnsemblBacteria b4469 http://www.ensemblgenomes.org/id/b4469 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003824 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003824 GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.80.30.20 http://www.cathdb.info/version/latest/superfamily/3.80.30.20 GeneID 948963 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948963 HAMAP MF_01251 http://hamap.expasy.org/unirule/MF_01251 HOGENOM HOG000230440 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230440&db=HOGENOM6 InParanoid Q46861 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46861 IntAct Q46861 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46861* InterPro IPR006638 http://www.ebi.ac.uk/interpro/entry/IPR006638 InterPro IPR007197 http://www.ebi.ac.uk/interpro/entry/IPR007197 InterPro IPR013704 http://www.ebi.ac.uk/interpro/entry/IPR013704 InterPro IPR020612 http://www.ebi.ac.uk/interpro/entry/IPR020612 InterPro IPR022946 http://www.ebi.ac.uk/interpro/entry/IPR022946 InterPro IPR023404 http://www.ebi.ac.uk/interpro/entry/IPR023404 InterPro IPR024560 http://www.ebi.ac.uk/interpro/entry/IPR024560 KEGG_Gene ecj:JW5501 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5501 KEGG_Gene eco:b4469 http://www.genome.jp/dbget-bin/www_bget?eco:b4469 OMA NLNTDHS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NLNTDHS PSORT swissprot:YGIQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGIQ_ECOLI PSORT-B swissprot:YGIQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGIQ_ECOLI PSORT2 swissprot:YGIQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGIQ_ECOLI Pfam PF04055 http://pfam.xfam.org/family/PF04055 Pfam PF08497 http://pfam.xfam.org/family/PF08497 Pfam PF11842 http://pfam.xfam.org/family/PF11842 Phobius swissprot:YGIQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGIQ_ECOLI PhylomeDB Q46861 http://phylomedb.org/?seqid=Q46861 ProteinModelPortal Q46861 http://www.proteinmodelportal.org/query/uniprot/Q46861 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000095187 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000095187 RefSeq YP_026196 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026196 SMART SM00729 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00729 STRING 511145.b4469 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4469&targetmode=cogs TIGRFAMs TIGR03904 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03904 UniProtKB YGIQ_ECOLI http://www.uniprot.org/uniprot/YGIQ_ECOLI UniProtKB-AC Q46861 http://www.uniprot.org/uniprot/Q46861 charge swissprot:YGIQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGIQ_ECOLI eggNOG COG1032 http://eggnogapi.embl.de/nog_data/html/tree/COG1032 eggNOG ENOG4105CCT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CCT epestfind swissprot:YGIQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGIQ_ECOLI garnier swissprot:YGIQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGIQ_ECOLI helixturnhelix swissprot:YGIQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGIQ_ECOLI hmoment swissprot:YGIQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGIQ_ECOLI iep swissprot:YGIQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGIQ_ECOLI inforesidue swissprot:YGIQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGIQ_ECOLI octanol swissprot:YGIQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGIQ_ECOLI pepcoil swissprot:YGIQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGIQ_ECOLI pepdigest swissprot:YGIQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGIQ_ECOLI pepinfo swissprot:YGIQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGIQ_ECOLI pepnet swissprot:YGIQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGIQ_ECOLI pepstats swissprot:YGIQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGIQ_ECOLI pepwheel swissprot:YGIQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGIQ_ECOLI pepwindow swissprot:YGIQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGIQ_ECOLI sigcleave swissprot:YGIQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGIQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4262676 11 # EcoGene EG11947 nrfD # FUNCTION NRFD_ECOLI Probably involved in the transfer of electrons from the quinone pool to the type-c cytochromes. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR005614 NrfD_fam # InterPro IPR017566 NrfD # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko00910 Nitrogen metabolism # Organism NRFD_ECOLI Escherichia coli (strain K12) # PATRIC 32123695 VBIEscCol129921_4196 # PIR H65215 D57987 # Pfam PF03916 NrfD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NRFD_ECOLI Protein NrfD # RefSeq NP_418497 NC_000913.3 # RefSeq WP_000195171 NZ_LN832404.1 # SIMILARITY Belongs to the NrfD family. {ECO 0000305}. # SUBCELLULAR LOCATION NRFD_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # TIGRFAMs TIGR03148 cyt_nit_nrfD # eggNOG COG3301 LUCA # eggNOG ENOG4105DVI Bacteria BLAST swissprot:NRFD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NRFD_ECOLI BioCyc ECOL316407:JW4034-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4034-MONOMER BioCyc EcoCyc:NRFD-MONOMER http://biocyc.org/getid?id=EcoCyc:NRFD-MONOMER BioCyc MetaCyc:NRFD-MONOMER http://biocyc.org/getid?id=MetaCyc:NRFD-MONOMER COG COG3301 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3301 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1111/j.1365-2958.1994.tb01004.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb01004.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X72298 http://www.ebi.ac.uk/ena/data/view/X72298 EchoBASE EB1890 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1890 EcoGene EG11947 http://www.ecogene.org/geneInfo.php?eg_id=EG11947 EnsemblBacteria AAC77043 http://www.ensemblgenomes.org/id/AAC77043 EnsemblBacteria AAC77043 http://www.ensemblgenomes.org/id/AAC77043 EnsemblBacteria BAE78075 http://www.ensemblgenomes.org/id/BAE78075 EnsemblBacteria BAE78075 http://www.ensemblgenomes.org/id/BAE78075 EnsemblBacteria BAE78075 http://www.ensemblgenomes.org/id/BAE78075 EnsemblBacteria b4073 http://www.ensemblgenomes.org/id/b4073 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 948580 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948580 HOGENOM HOG000278536 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278536&db=HOGENOM6 InParanoid P32709 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32709 InterPro IPR005614 http://www.ebi.ac.uk/interpro/entry/IPR005614 InterPro IPR017566 http://www.ebi.ac.uk/interpro/entry/IPR017566 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW4034 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4034 KEGG_Gene eco:b4073 http://www.genome.jp/dbget-bin/www_bget?eco:b4073 KEGG_Orthology KO:K04015 http://www.genome.jp/dbget-bin/www_bget?KO:K04015 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 OMA FVHRMET http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FVHRMET PSORT swissprot:NRFD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NRFD_ECOLI PSORT-B swissprot:NRFD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NRFD_ECOLI PSORT2 swissprot:NRFD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NRFD_ECOLI Pfam PF03916 http://pfam.xfam.org/family/PF03916 Phobius swissprot:NRFD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NRFD_ECOLI ProteinModelPortal P32709 http://www.proteinmodelportal.org/query/uniprot/P32709 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8057835 http://www.ncbi.nlm.nih.gov/pubmed/8057835 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418497 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418497 RefSeq WP_000195171 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000195171 STRING 511145.b4073 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4073&targetmode=cogs STRING COG3301 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3301&targetmode=cogs TIGRFAMs TIGR03148 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03148 UniProtKB NRFD_ECOLI http://www.uniprot.org/uniprot/NRFD_ECOLI UniProtKB-AC P32709 http://www.uniprot.org/uniprot/P32709 charge swissprot:NRFD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NRFD_ECOLI eggNOG COG3301 http://eggnogapi.embl.de/nog_data/html/tree/COG3301 eggNOG ENOG4105DVI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DVI epestfind swissprot:NRFD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NRFD_ECOLI garnier swissprot:NRFD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NRFD_ECOLI helixturnhelix swissprot:NRFD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NRFD_ECOLI hmoment swissprot:NRFD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NRFD_ECOLI iep swissprot:NRFD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NRFD_ECOLI inforesidue swissprot:NRFD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NRFD_ECOLI octanol swissprot:NRFD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NRFD_ECOLI pepcoil swissprot:NRFD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NRFD_ECOLI pepdigest swissprot:NRFD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NRFD_ECOLI pepinfo swissprot:NRFD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NRFD_ECOLI pepnet swissprot:NRFD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NRFD_ECOLI pepstats swissprot:NRFD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NRFD_ECOLI pepwheel swissprot:NRFD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NRFD_ECOLI pepwindow swissprot:NRFD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NRFD_ECOLI sigcleave swissprot:NRFD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NRFD_ECOLI ## Database ID URL or Descriptions # BioGrid 4261316 32 # EcoGene EG13467 yphF # FUNCTION YPHF_ECOLI Probably part of the binding-protein-dependent transport system YphDEF. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_process GO:0006810 transport; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0006810 transport # IntAct P77269 3 # InterPro IPR025997 SBP_2_dom # InterPro IPR028082 Peripla_BP_I # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00221 Putative simple sugar transport system # KEGG_Brite ko02000 Transporters # Organism YPHF_ECOLI Escherichia coli (strain K12) # PATRIC 32120493 VBIEscCol129921_2649 # PIR C65032 C65032 # Pfam PF13407 Peripla_BP_4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YPHF_ECOLI ABC transporter periplasmic-binding protein YphF # RefSeq NP_417043 NC_000913.3 # RefSeq WP_001142427 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial solute-binding protein 2 family. {ECO 0000305}. # SUBCELLULAR LOCATION YPHF_ECOLI Periplasm {ECO 0000305}. # SUPFAM SSF53822 SSF53822 # TCDB 3.A.1.2.27 the atp-binding cassette (abc) superfamily # eggNOG COG1879 LUCA # eggNOG ENOG4105FCA Bacteria BLAST swissprot:YPHF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YPHF_ECOLI BioCyc ECOL316407:JW2532-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2532-MONOMER BioCyc EcoCyc:G7342-MONOMER http://biocyc.org/getid?id=EcoCyc:G7342-MONOMER COG COG1879 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1879 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3240 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3240 EcoGene EG13467 http://www.ecogene.org/geneInfo.php?eg_id=EG13467 EnsemblBacteria AAC75601 http://www.ensemblgenomes.org/id/AAC75601 EnsemblBacteria AAC75601 http://www.ensemblgenomes.org/id/AAC75601 EnsemblBacteria BAA16457 http://www.ensemblgenomes.org/id/BAA16457 EnsemblBacteria BAA16457 http://www.ensemblgenomes.org/id/BAA16457 EnsemblBacteria BAA16457 http://www.ensemblgenomes.org/id/BAA16457 EnsemblBacteria b2548 http://www.ensemblgenomes.org/id/b2548 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 947020 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947020 HOGENOM HOG000078217 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000078217&db=HOGENOM6 IntAct P77269 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77269* InterPro IPR025997 http://www.ebi.ac.uk/interpro/entry/IPR025997 InterPro IPR028082 http://www.ebi.ac.uk/interpro/entry/IPR028082 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2532 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2532 KEGG_Gene eco:b2548 http://www.genome.jp/dbget-bin/www_bget?eco:b2548 KEGG_Orthology KO:K02058 http://www.genome.jp/dbget-bin/www_bget?KO:K02058 OMA KGGDKYV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KGGDKYV PSORT swissprot:YPHF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YPHF_ECOLI PSORT-B swissprot:YPHF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YPHF_ECOLI PSORT2 swissprot:YPHF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YPHF_ECOLI Pfam PF13407 http://pfam.xfam.org/family/PF13407 Phobius swissprot:YPHF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YPHF_ECOLI PhylomeDB P77269 http://phylomedb.org/?seqid=P77269 ProteinModelPortal P77269 http://www.proteinmodelportal.org/query/uniprot/P77269 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_417043 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417043 RefSeq WP_001142427 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001142427 SMR P77269 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77269 STRING 511145.b2548 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2548&targetmode=cogs STRING COG1879 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1879&targetmode=cogs SUPFAM SSF53822 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822 TCDB 3.A.1.2.27 http://www.tcdb.org/search/result.php?tc=3.A.1.2.27 UniProtKB YPHF_ECOLI http://www.uniprot.org/uniprot/YPHF_ECOLI UniProtKB-AC P77269 http://www.uniprot.org/uniprot/P77269 charge swissprot:YPHF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YPHF_ECOLI eggNOG COG1879 http://eggnogapi.embl.de/nog_data/html/tree/COG1879 eggNOG ENOG4105FCA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FCA epestfind swissprot:YPHF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YPHF_ECOLI garnier swissprot:YPHF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YPHF_ECOLI helixturnhelix swissprot:YPHF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YPHF_ECOLI hmoment swissprot:YPHF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YPHF_ECOLI iep swissprot:YPHF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YPHF_ECOLI inforesidue swissprot:YPHF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YPHF_ECOLI octanol swissprot:YPHF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YPHF_ECOLI pepcoil swissprot:YPHF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YPHF_ECOLI pepdigest swissprot:YPHF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YPHF_ECOLI pepinfo swissprot:YPHF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YPHF_ECOLI pepnet swissprot:YPHF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YPHF_ECOLI pepstats swissprot:YPHF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YPHF_ECOLI pepwheel swissprot:YPHF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YPHF_ECOLI pepwindow swissprot:YPHF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YPHF_ECOLI sigcleave swissprot:YPHF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YPHF_ECOLI ## Database ID URL or Descriptions # BRENDA 1.4.3.B1 2026 # BioGrid 4263527 12 # CATALYTIC ACTIVITY PUUB_ECOLI Gamma-glutamylputrescine + H(2)O + O(2) = Gamma-glutamyl-gamma-aminobutyraldehyde + NH(3) + H(2)O(2). # EcoGene EG11822 puuB # FUNCTION PUUB_ECOLI Involved in the breakdown of putrescine via the oxidation of L-glutamylputrescine. {ECO 0000269|PubMed 15590624}. # GO_function GO:0016491 oxidoreductase activity; IMP:UniProtKB. # GO_process GO:0009447 putrescine catabolic process; IEA:UniProtKB-UniPathway. # GO_process GO:0055114 oxidation-reduction process; IMP:UniProtKB. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.50.50.60 -; 3. # IntAct P37906 18 # InterPro IPR006076 FAD-dep_OxRdtase # InterPro IPR023753 FAD/NAD-binding_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00330 Arginine and proline metabolism # Organism PUUB_ECOLI Escherichia coli (strain K12) # PATHWAY Amine and polyamine degradation; putrescine degradation; 4-aminobutanoate from putrescine step 2/4. # PATRIC 32117874 VBIEscCol129921_1357 # PIR H64878 H64878 # Pfam PF01266 DAO # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PUUB_ECOLI Gamma-glutamylputrescine oxidoreductase # RefSeq NP_415817 NC_000913.3 # RefSeq WP_000134870 NZ_LN832404.1 # SIMILARITY Belongs to the gamma-glutamylputrescine oxidoreductase family. {ECO 0000305}. # SUPFAM SSF51905 SSF51905; 2 # UniPathway UPA00188 UER00881 # eggNOG ENOG4105CJP Bacteria # eggNOG ENOG410XWBT LUCA BLAST swissprot:PUUB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PUUB_ECOLI BioCyc ECOL316407:JW1294-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1294-MONOMER BioCyc EcoCyc:EG11822-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11822-MONOMER BioCyc MetaCyc:EG11822-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11822-MONOMER COG COG0665 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0665 DOI 10.1016/0378-1119(91)90028-A http://dx.doi.org/10.1016/0378-1119(91)90028-A DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M411114200 http://dx.doi.org/10.1074/jbc.M411114200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.4.3.- http://www.genome.jp/dbget-bin/www_bget?EC:1.4.3.- EMBL AB200320 http://www.ebi.ac.uk/ena/data/view/AB200320 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M38433 http://www.ebi.ac.uk/ena/data/view/M38433 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U38543 http://www.ebi.ac.uk/ena/data/view/U38543 ENZYME 1.4.3.- http://enzyme.expasy.org/EC/1.4.3.- EchoBASE EB1769 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1769 EcoGene EG11822 http://www.ecogene.org/geneInfo.php?eg_id=EG11822 EnsemblBacteria AAC74383 http://www.ensemblgenomes.org/id/AAC74383 EnsemblBacteria AAC74383 http://www.ensemblgenomes.org/id/AAC74383 EnsemblBacteria BAA14870 http://www.ensemblgenomes.org/id/BAA14870 EnsemblBacteria BAA14870 http://www.ensemblgenomes.org/id/BAA14870 EnsemblBacteria BAA14870 http://www.ensemblgenomes.org/id/BAA14870 EnsemblBacteria b1301 http://www.ensemblgenomes.org/id/b1301 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_process GO:0009447 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009447 GO_process GO:0055114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 GeneID 945072 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945072 HOGENOM HOG000185563 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000185563&db=HOGENOM6 InParanoid P37906 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37906 IntAct P37906 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37906* IntEnz 1.4.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.4.3 InterPro IPR006076 http://www.ebi.ac.uk/interpro/entry/IPR006076 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1294 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1294 KEGG_Gene eco:b1301 http://www.genome.jp/dbget-bin/www_bget?eco:b1301 KEGG_Orthology KO:K09471 http://www.genome.jp/dbget-bin/www_bget?KO:K09471 KEGG_Pathway ko00330 http://www.genome.jp/kegg-bin/show_pathway?ko00330 KEGG_Reaction rn:R07415 http://www.genome.jp/dbget-bin/www_bget?rn:R07415 OMA IECDYRP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IECDYRP PSORT swissprot:PUUB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PUUB_ECOLI PSORT-B swissprot:PUUB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PUUB_ECOLI PSORT2 swissprot:PUUB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PUUB_ECOLI Pfam PF01266 http://pfam.xfam.org/family/PF01266 Phobius swissprot:PUUB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PUUB_ECOLI PhylomeDB P37906 http://phylomedb.org/?seqid=P37906 ProteinModelPortal P37906 http://www.proteinmodelportal.org/query/uniprot/P37906 PubMed 15590624 http://www.ncbi.nlm.nih.gov/pubmed/15590624 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1840553 http://www.ncbi.nlm.nih.gov/pubmed/1840553 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415817 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415817 RefSeq WP_000134870 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000134870 STRING 511145.b1301 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1301&targetmode=cogs STRING COG0665 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0665&targetmode=cogs SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 UniProtKB PUUB_ECOLI http://www.uniprot.org/uniprot/PUUB_ECOLI UniProtKB-AC P37906 http://www.uniprot.org/uniprot/P37906 charge swissprot:PUUB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PUUB_ECOLI eggNOG ENOG4105CJP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CJP eggNOG ENOG410XWBT http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XWBT epestfind swissprot:PUUB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PUUB_ECOLI garnier swissprot:PUUB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PUUB_ECOLI helixturnhelix swissprot:PUUB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PUUB_ECOLI hmoment swissprot:PUUB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PUUB_ECOLI iep swissprot:PUUB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PUUB_ECOLI inforesidue swissprot:PUUB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PUUB_ECOLI octanol swissprot:PUUB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PUUB_ECOLI pepcoil swissprot:PUUB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PUUB_ECOLI pepdigest swissprot:PUUB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PUUB_ECOLI pepinfo swissprot:PUUB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PUUB_ECOLI pepnet swissprot:PUUB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PUUB_ECOLI pepstats swissprot:PUUB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PUUB_ECOLI pepwheel swissprot:PUUB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PUUB_ECOLI pepwindow swissprot:PUUB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PUUB_ECOLI sigcleave swissprot:PUUB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PUUB_ECOLI ## Database ID URL or Descriptions # InterPro IPR026325 DUF932 # Organism YUBP_ECOLI Escherichia coli (strain K12) # PIR JN0037 JN0037 # PIR S07014 S07014 # Pfam PF06067 DUF932 # RecName YUBP_ECOLI UPF0380 protein YubP # RefSeq NP_061448 NC_002483.1 # RefSeq WP_001234417 NC_002483.1 # SIMILARITY Belongs to the UPF0380 family. {ECO 0000305}. BLAST swissprot:YUBP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YUBP_ECOLI DOI 10.1007/BF00261174 http://dx.doi.org/10.1007/BF00261174 DOI 10.1093/nar/18.4.1046 http://dx.doi.org/10.1093/nar/18.4.1046 EMBL AF106329 http://www.ebi.ac.uk/ena/data/view/AF106329 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL X15279 http://www.ebi.ac.uk/ena/data/view/X15279 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1263600 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263600 InterPro IPR026325 http://www.ebi.ac.uk/interpro/entry/IPR026325 OMA FHKGVAV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FHKGVAV PSORT swissprot:YUBP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YUBP_ECOLI PSORT-B swissprot:YUBP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YUBP_ECOLI PSORT2 swissprot:YUBP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YUBP_ECOLI Pfam PF06067 http://pfam.xfam.org/family/PF06067 Phobius swissprot:YUBP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YUBP_ECOLI ProteinModelPortal P18005 http://www.proteinmodelportal.org/query/uniprot/P18005 PubMed 2315017 http://www.ncbi.nlm.nih.gov/pubmed/2315017 PubMed 2693941 http://www.ncbi.nlm.nih.gov/pubmed/2693941 RefSeq NP_061448 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061448 RefSeq WP_001234417 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001234417 UniProtKB YUBP_ECOLI http://www.uniprot.org/uniprot/YUBP_ECOLI UniProtKB-AC P18005 http://www.uniprot.org/uniprot/P18005 charge swissprot:YUBP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YUBP_ECOLI epestfind swissprot:YUBP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YUBP_ECOLI garnier swissprot:YUBP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YUBP_ECOLI helixturnhelix swissprot:YUBP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YUBP_ECOLI hmoment swissprot:YUBP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YUBP_ECOLI iep swissprot:YUBP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YUBP_ECOLI inforesidue swissprot:YUBP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YUBP_ECOLI octanol swissprot:YUBP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YUBP_ECOLI pepcoil swissprot:YUBP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YUBP_ECOLI pepdigest swissprot:YUBP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YUBP_ECOLI pepinfo swissprot:YUBP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YUBP_ECOLI pepnet swissprot:YUBP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YUBP_ECOLI pepstats swissprot:YUBP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YUBP_ECOLI pepwheel swissprot:YUBP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YUBP_ECOLI pepwindow swissprot:YUBP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YUBP_ECOLI sigcleave swissprot:YUBP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YUBP_ECOLI ## Database ID URL or Descriptions # AltName ELYC_ECOLI Elevated frequency of lysis # BioGrid 4263426 296 # CDD cd06259 YdcF-like # DISRUPTION PHENOTYPE Deletion causes a severe growth defect at low temperature and an elevated frequency of cell lysis resulting from impaired metabolism of the essential lipid precursor required for peptidoglycan synthesis. {ECO:0000269|PubMed 24391520}. # EcoGene EG12166 elyC # FUNCTION ELYC_ECOLI Plays a critical role in the metabolism of the essential lipid carrier used for cell wall synthesis. {ECO 0000269|PubMed 24391520}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IBA:GO_Central. # GO_process GO:0000270 peptidoglycan metabolic process; IMP:EcoCyc. # GO_process GO:0043164 Gram-negative-bacterium-type cell wall biogenesis; IMP:EcoCyc. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0008150 biological_process # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 3.40.50.620 -; 1. # IntAct P0AB01 3 # InterPro IPR003848 DUF218 # InterPro IPR014729 Rossmann-like_a/b/a_fold # Organism ELYC_ECOLI Escherichia coli (strain K12) # PATRIC 32117053 VBIEscCol129921_0951 # PIR G64831 G64831 # Pfam PF02698 DUF218 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ELYC_ECOLI Envelope biogenesis factor ElyC # RefSeq NP_415440 NC_000913.3 # RefSeq WP_000899600 NZ_LN832404.1 # SUBCELLULAR LOCATION ELYC_ECOLI Cell inner membrane {ECO 0000305}; Multi- pass membrane protein {ECO 0000305}. # eggNOG COG1434 LUCA # eggNOG ENOG4107S90 Bacteria BLAST swissprot:ELYC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ELYC_ECOLI BioCyc ECOL316407:JW0903-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0903-MONOMER BioCyc EcoCyc:EG12166-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12166-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pgen.1004056 http://dx.doi.org/10.1371/journal.pgen.1004056 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D26440 http://www.ebi.ac.uk/ena/data/view/D26440 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2085 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2085 EcoGene EG12166 http://www.ecogene.org/geneInfo.php?eg_id=EG12166 EnsemblBacteria AAC74006 http://www.ensemblgenomes.org/id/AAC74006 EnsemblBacteria AAC74006 http://www.ensemblgenomes.org/id/AAC74006 EnsemblBacteria BAA35666 http://www.ensemblgenomes.org/id/BAA35666 EnsemblBacteria BAA35666 http://www.ensemblgenomes.org/id/BAA35666 EnsemblBacteria BAA35666 http://www.ensemblgenomes.org/id/BAA35666 EnsemblBacteria b0920 http://www.ensemblgenomes.org/id/b0920 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0000270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000270 GO_process GO:0043164 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043164 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 GeneID 945546 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945546 HOGENOM HOG000259549 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000259549&db=HOGENOM6 InParanoid P0AB01 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AB01 IntAct P0AB01 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AB01* InterPro IPR003848 http://www.ebi.ac.uk/interpro/entry/IPR003848 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 KEGG_Gene ecj:JW0903 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0903 KEGG_Gene eco:b0920 http://www.genome.jp/dbget-bin/www_bget?eco:b0920 OMA LWFTRWQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LWFTRWQ PSORT swissprot:ELYC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ELYC_ECOLI PSORT-B swissprot:ELYC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ELYC_ECOLI PSORT2 swissprot:ELYC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ELYC_ECOLI Pfam PF02698 http://pfam.xfam.org/family/PF02698 Phobius swissprot:ELYC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ELYC_ECOLI PhylomeDB P0AB01 http://phylomedb.org/?seqid=P0AB01 ProteinModelPortal P0AB01 http://www.proteinmodelportal.org/query/uniprot/P0AB01 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 24391520 http://www.ncbi.nlm.nih.gov/pubmed/24391520 PubMed 7513784 http://www.ncbi.nlm.nih.gov/pubmed/7513784 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415440 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415440 RefSeq WP_000899600 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000899600 SMR P0AB01 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AB01 STRING 511145.b0920 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0920&targetmode=cogs UniProtKB ELYC_ECOLI http://www.uniprot.org/uniprot/ELYC_ECOLI UniProtKB-AC P0AB01 http://www.uniprot.org/uniprot/P0AB01 charge swissprot:ELYC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ELYC_ECOLI eggNOG COG1434 http://eggnogapi.embl.de/nog_data/html/tree/COG1434 eggNOG ENOG4107S90 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107S90 epestfind swissprot:ELYC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ELYC_ECOLI garnier swissprot:ELYC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ELYC_ECOLI helixturnhelix swissprot:ELYC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ELYC_ECOLI hmoment swissprot:ELYC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ELYC_ECOLI iep swissprot:ELYC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ELYC_ECOLI inforesidue swissprot:ELYC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ELYC_ECOLI octanol swissprot:ELYC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ELYC_ECOLI pepcoil swissprot:ELYC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ELYC_ECOLI pepdigest swissprot:ELYC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ELYC_ECOLI pepinfo swissprot:ELYC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ELYC_ECOLI pepnet swissprot:ELYC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ELYC_ECOLI pepstats swissprot:ELYC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ELYC_ECOLI pepwheel swissprot:ELYC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ELYC_ECOLI pepwindow swissprot:ELYC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ELYC_ECOLI sigcleave swissprot:ELYC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ELYC_ECOLI ## Database ID URL or Descriptions # EcoGene EG14180 yffS # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # Gene3D 1.10.260.40 -; 1. # InterPro IPR010982 Lambda_DNA-bd_dom # Organism YFFS_ECOLI Escherichia coli (strain K12) # PATRIC 32120281 VBIEscCol129921_2543 # PIR A65020 A65020 # Proteomes UP000000625 Chromosome # RecName YFFS_ECOLI Uncharacterized protein YffS # RefSeq NP_416945 NC_000913.3 # RefSeq WP_010723125 NZ_CP014272.1 BLAST swissprot:YFFS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFFS_ECOLI BioCyc EcoCyc:G7280-MONOMER http://biocyc.org/getid?id=EcoCyc:G7280-MONOMER DIP DIP-12033N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12033N DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3932 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3932 EcoGene EG14180 http://www.ecogene.org/geneInfo.php?eg_id=EG14180 EnsemblBacteria AAC75503 http://www.ensemblgenomes.org/id/AAC75503 EnsemblBacteria AAC75503 http://www.ensemblgenomes.org/id/AAC75503 EnsemblBacteria b2450 http://www.ensemblgenomes.org/id/b2450 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 Gene3D 1.10.260.40 http://www.cathdb.info/version/latest/superfamily/1.10.260.40 GeneID 946932 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946932 HOGENOM HOG000050891 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000050891&db=HOGENOM6 InterPro IPR010982 http://www.ebi.ac.uk/interpro/entry/IPR010982 KEGG_Gene eco:b2450 http://www.genome.jp/dbget-bin/www_bget?eco:b2450 OMA WMEGRRE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WMEGRRE PSORT swissprot:YFFS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFFS_ECOLI PSORT-B swissprot:YFFS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFFS_ECOLI PSORT2 swissprot:YFFS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFFS_ECOLI Phobius swissprot:YFFS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFFS_ECOLI ProteinModelPortal P76550 http://www.proteinmodelportal.org/query/uniprot/P76550 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416945 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416945 RefSeq WP_010723125 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_010723125 STRING 511145.b2450 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2450&targetmode=cogs UniProtKB YFFS_ECOLI http://www.uniprot.org/uniprot/YFFS_ECOLI UniProtKB-AC P76550 http://www.uniprot.org/uniprot/P76550 charge swissprot:YFFS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFFS_ECOLI epestfind swissprot:YFFS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFFS_ECOLI garnier swissprot:YFFS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFFS_ECOLI helixturnhelix swissprot:YFFS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFFS_ECOLI hmoment swissprot:YFFS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFFS_ECOLI iep swissprot:YFFS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFFS_ECOLI inforesidue swissprot:YFFS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFFS_ECOLI octanol swissprot:YFFS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFFS_ECOLI pepcoil swissprot:YFFS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFFS_ECOLI pepdigest swissprot:YFFS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFFS_ECOLI pepinfo swissprot:YFFS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFFS_ECOLI pepnet swissprot:YFFS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFFS_ECOLI pepstats swissprot:YFFS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFFS_ECOLI pepwheel swissprot:YFFS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFFS_ECOLI pepwindow swissprot:YFFS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFFS_ECOLI sigcleave swissprot:YFFS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFFS_ECOLI ## Database ID URL or Descriptions # AltName PPX_ECOLI Metaphosphatase # BioGrid 4260594 9 # CATALYTIC ACTIVITY PPX_ECOLI (Polyphosphate)(n) + H(2)O = (polyphosphate)(n-1) + phosphate. # COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI 18420; # EcoGene EG11403 ppx # FUNCTION PPX_ECOLI Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate of circa 500 residues long, while chains of circa 15 residues compete poorly with polyphosphate as substrate. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_function GO:0004309 exopolyphosphatase activity; IDA:EcoCyc. # GO_process GO:0006798 polyphosphate catabolic process; IMP:EcoCyc. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # IntAct P0AFL6 9 # InterPro IPR003695 Ppx_GppA # InterPro IPR022371 Exopolyphosphatase # InterPro IPR030673 PyroPPase_GppA_Ppx # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # Organism PPX_ECOLI Escherichia coli (strain K12) # PATRIC 32120393 VBIEscCol129921_2599 # PDB 1U6Z X-ray; 1.90 A; A/B=1-513 # PIR A45333 A45333 # PIRSF PIRSF001267 Pyrophosphatase_GppA_Ppx # Pfam PF02541 Ppx-GppA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PPX_ECOLI Exopolyphosphatase # RefSeq NP_416997 NC_000913.3 # RefSeq WP_001121363 NZ_LN832404.1 # SIMILARITY Belongs to the GppA/Ppx family. {ECO 0000305}. # SUBCELLULAR LOCATION PPX_ECOLI Cell membrane; Peripheral membrane protein. # SUBUNIT PPX_ECOLI Homodimer. # TIGRFAMs TIGR03706 exo_poly_only # eggNOG COG0248 LUCA # eggNOG ENOG4105C9X Bacteria BLAST swissprot:PPX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PPX_ECOLI BioCyc ECOL316407:JW2487-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2487-MONOMER BioCyc EcoCyc:PPX-MONOMER http://biocyc.org/getid?id=EcoCyc:PPX-MONOMER BioCyc MetaCyc:PPX-MONOMER http://biocyc.org/getid?id=MetaCyc:PPX-MONOMER COG COG0248 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0248 DIP DIP-29140N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-29140N DOI 10.1016/0968-0004(93)90172-J http://dx.doi.org/10.1016/0968-0004(93)90172-J DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.1.11 http://www.genome.jp/dbget-bin/www_bget?EC:3.6.1.11 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L06129 http://www.ebi.ac.uk/ena/data/view/L06129 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.6.1.11 http://enzyme.expasy.org/EC/3.6.1.11 EchoBASE EB1375 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1375 EcoGene EG11403 http://www.ecogene.org/geneInfo.php?eg_id=EG11403 EnsemblBacteria AAC75555 http://www.ensemblgenomes.org/id/AAC75555 EnsemblBacteria AAC75555 http://www.ensemblgenomes.org/id/AAC75555 EnsemblBacteria BAA16390 http://www.ensemblgenomes.org/id/BAA16390 EnsemblBacteria BAA16390 http://www.ensemblgenomes.org/id/BAA16390 EnsemblBacteria BAA16390 http://www.ensemblgenomes.org/id/BAA16390 EnsemblBacteria b2502 http://www.ensemblgenomes.org/id/b2502 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0004309 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004309 GO_process GO:0006798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006798 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 946970 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946970 HOGENOM HOG000258672 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000258672&db=HOGENOM6 InParanoid P0AFL6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFL6 IntAct P0AFL6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFL6* IntEnz 3.6.1.11 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.1.11 InterPro IPR003695 http://www.ebi.ac.uk/interpro/entry/IPR003695 InterPro IPR022371 http://www.ebi.ac.uk/interpro/entry/IPR022371 InterPro IPR030673 http://www.ebi.ac.uk/interpro/entry/IPR030673 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2487 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2487 KEGG_Gene eco:b2502 http://www.genome.jp/dbget-bin/www_bget?eco:b2502 KEGG_Orthology KO:K01524 http://www.genome.jp/dbget-bin/www_bget?KO:K01524 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Reaction rn:R03409 http://www.genome.jp/dbget-bin/www_bget?rn:R03409 MINT MINT-1285895 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1285895 OMA FETKSRV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FETKSRV PDB 1U6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/1U6Z PDBsum 1U6Z http://www.ebi.ac.uk/pdbsum/1U6Z PSORT swissprot:PPX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PPX_ECOLI PSORT-B swissprot:PPX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PPX_ECOLI PSORT2 swissprot:PPX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PPX_ECOLI Pfam PF02541 http://pfam.xfam.org/family/PF02541 Phobius swissprot:PPX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PPX_ECOLI PhylomeDB P0AFL6 http://phylomedb.org/?seqid=P0AFL6 ProteinModelPortal P0AFL6 http://www.proteinmodelportal.org/query/uniprot/P0AFL6 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8212131 http://www.ncbi.nlm.nih.gov/pubmed/8212131 PubMed 8380170 http://www.ncbi.nlm.nih.gov/pubmed/8380170 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416997 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416997 RefSeq WP_001121363 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001121363 SMR P0AFL6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFL6 STRING 511145.b2502 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2502&targetmode=cogs STRING COG0248 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0248&targetmode=cogs TIGRFAMs TIGR03706 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03706 UniProtKB PPX_ECOLI http://www.uniprot.org/uniprot/PPX_ECOLI UniProtKB-AC P0AFL6 http://www.uniprot.org/uniprot/P0AFL6 charge swissprot:PPX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PPX_ECOLI eggNOG COG0248 http://eggnogapi.embl.de/nog_data/html/tree/COG0248 eggNOG ENOG4105C9X http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C9X epestfind swissprot:PPX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PPX_ECOLI garnier swissprot:PPX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PPX_ECOLI helixturnhelix swissprot:PPX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PPX_ECOLI hmoment swissprot:PPX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PPX_ECOLI iep swissprot:PPX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PPX_ECOLI inforesidue swissprot:PPX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PPX_ECOLI octanol swissprot:PPX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PPX_ECOLI pepcoil swissprot:PPX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PPX_ECOLI pepdigest swissprot:PPX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PPX_ECOLI pepinfo swissprot:PPX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PPX_ECOLI pepnet swissprot:PPX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PPX_ECOLI pepstats swissprot:PPX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PPX_ECOLI pepwheel swissprot:PPX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PPX_ECOLI pepwindow swissprot:PPX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PPX_ECOLI sigcleave swissprot:PPX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PPX_ECOLI ## Database ID URL or Descriptions # AltName TRMD_ECOLI M1G-methyltransferase # AltName TRMD_ECOLI tRNA [GM37] methyltransferase # BRENDA 2.1.1.228 2026 # BioGrid 4263072 18 # CATALYTIC ACTIVITY TRMD_ECOLI S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA. # EcoGene EG11023 trmD # FUNCTION TRMD_ECOLI Specifically methylates guanosine-37 in various tRNAs. {ECO 0000269|PubMed 14583191}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0008685 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity; IBA:GO_Central. # GO_function GO:0009019 tRNA (guanine-N1-)-methyltransferase activity; IDA:EcoCyc. # GO_function GO:0052906 tRNA (guanine(37)-N(1))-methyltransferase activity; IDA:EcoCyc. # GO_process GO:0002939 tRNA N1-guanine methylation; IDA:EcoCyc. # GO_process GO:0030488 tRNA methylation; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0008168 methyltransferase activity # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # Gene3D 1.10.1270.20 -; 1. # Gene3D 3.40.1280.10 -; 1. # HAMAP MF_00605 TrmD # INDUCTION TRMD_ECOLI Part of the rpsP-rimM-trmD-rplS operon. # INTERACTION TRMD_ECOLI Self; NbExp=3; IntAct=EBI-1129132, EBI-1129132; # InterPro IPR002649 tRNA_m1G_MeTrfase_bac # InterPro IPR016009 tRNA_MeTrfase_TRMD/TRM10 # InterPro IPR023148 tRNA_m1G_MeTrfase_C # InterPro IPR029026 tRNA_m1G_MTases_N # InterPro IPR029028 Alpha/beta_knot_MTases # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # MISCELLANEOUS TRMD_ECOLI The specific activity of this enzyme increases only slightly with increased growth rate. # MISCELLANEOUS TRMD_ECOLI This enzyme is present at ca. 80 molecules/genome. # Organism TRMD_ECOLI Escherichia coli (strain K12) # PATRIC 32120613 VBIEscCol129921_2705 # PDB 1P9P X-ray; 2.50 A; A=1-255 # PIR A30380 XYECG1 # PIRSF PIRSF000386 tRNA_mtase # Pfam PF01746 tRNA_m1G_MT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TRMD_ECOLI tRNA (guanine-N(1)-)-methyltransferase # RefSeq NP_417098 NC_000913.3 # RefSeq WP_000264777 NZ_LN832404.1 # SIMILARITY Belongs to the RNA methyltransferase TrmD family. {ECO 0000305}. # SUBCELLULAR LOCATION TRMD_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 14583191}. # SUPFAM SSF75217 SSF75217 # TIGRFAMs TIGR00088 trmD # eggNOG COG0336 LUCA # eggNOG ENOG4105D6X Bacteria BLAST swissprot:TRMD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRMD_ECOLI BioCyc ECOL316407:JW2588-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2588-MONOMER BioCyc EcoCyc:EG11023-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11023-MONOMER BioCyc MetaCyc:EG11023-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11023-MONOMER COG COG0336 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0336 DIP DIP-48264N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48264N DOI 10.1016/j.jmb.2003.09.011 http://dx.doi.org/10.1016/j.jmb.2003.09.011 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.1.228 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.228 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X01818 http://www.ebi.ac.uk/ena/data/view/X01818 ENZYME 2.1.1.228 http://enzyme.expasy.org/EC/2.1.1.228 EchoBASE EB1016 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1016 EcoGene EG11023 http://www.ecogene.org/geneInfo.php?eg_id=EG11023 EnsemblBacteria AAC75656 http://www.ensemblgenomes.org/id/AAC75656 EnsemblBacteria AAC75656 http://www.ensemblgenomes.org/id/AAC75656 EnsemblBacteria BAA16492 http://www.ensemblgenomes.org/id/BAA16492 EnsemblBacteria BAA16492 http://www.ensemblgenomes.org/id/BAA16492 EnsemblBacteria BAA16492 http://www.ensemblgenomes.org/id/BAA16492 EnsemblBacteria b2607 http://www.ensemblgenomes.org/id/b2607 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0008685 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008685 GO_function GO:0009019 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009019 GO_function GO:0052906 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052906 GO_process GO:0002939 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002939 GO_process GO:0030488 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030488 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 Gene3D 1.10.1270.20 http://www.cathdb.info/version/latest/superfamily/1.10.1270.20 Gene3D 3.40.1280.10 http://www.cathdb.info/version/latest/superfamily/3.40.1280.10 GeneID 947099 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947099 HAMAP MF_00605 http://hamap.expasy.org/unirule/MF_00605 HOGENOM HOG000016242 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000016242&db=HOGENOM6 InParanoid P0A873 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A873 IntAct P0A873 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A873* IntEnz 2.1.1.228 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.228 InterPro IPR002649 http://www.ebi.ac.uk/interpro/entry/IPR002649 InterPro IPR016009 http://www.ebi.ac.uk/interpro/entry/IPR016009 InterPro IPR023148 http://www.ebi.ac.uk/interpro/entry/IPR023148 InterPro IPR029026 http://www.ebi.ac.uk/interpro/entry/IPR029026 InterPro IPR029028 http://www.ebi.ac.uk/interpro/entry/IPR029028 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW2588 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2588 KEGG_Gene eco:b2607 http://www.genome.jp/dbget-bin/www_bget?eco:b2607 KEGG_Orthology KO:K00554 http://www.genome.jp/dbget-bin/www_bget?KO:K00554 OMA YKGVDQR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YKGVDQR PDB 1P9P http://www.ebi.ac.uk/pdbe-srv/view/entry/1P9P PDBsum 1P9P http://www.ebi.ac.uk/pdbsum/1P9P PSORT swissprot:TRMD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRMD_ECOLI PSORT-B swissprot:TRMD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRMD_ECOLI PSORT2 swissprot:TRMD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRMD_ECOLI Pfam PF01746 http://pfam.xfam.org/family/PF01746 Phobius swissprot:TRMD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRMD_ECOLI PhylomeDB P0A873 http://phylomedb.org/?seqid=P0A873 ProteinModelPortal P0A873 http://www.proteinmodelportal.org/query/uniprot/P0A873 PubMed 14583191 http://www.ncbi.nlm.nih.gov/pubmed/14583191 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6337136 http://www.ncbi.nlm.nih.gov/pubmed/6337136 PubMed 6357787 http://www.ncbi.nlm.nih.gov/pubmed/6357787 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417098 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417098 RefSeq WP_000264777 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000264777 SMR P0A873 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A873 STRING 511145.b2607 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2607&targetmode=cogs STRING COG0336 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0336&targetmode=cogs SUPFAM SSF75217 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF75217 TIGRFAMs TIGR00088 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00088 UniProtKB TRMD_ECOLI http://www.uniprot.org/uniprot/TRMD_ECOLI UniProtKB-AC P0A873 http://www.uniprot.org/uniprot/P0A873 charge swissprot:TRMD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRMD_ECOLI eggNOG COG0336 http://eggnogapi.embl.de/nog_data/html/tree/COG0336 eggNOG ENOG4105D6X http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D6X epestfind swissprot:TRMD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRMD_ECOLI garnier swissprot:TRMD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRMD_ECOLI helixturnhelix swissprot:TRMD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRMD_ECOLI hmoment swissprot:TRMD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRMD_ECOLI iep swissprot:TRMD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRMD_ECOLI inforesidue swissprot:TRMD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRMD_ECOLI octanol swissprot:TRMD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRMD_ECOLI pepcoil swissprot:TRMD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRMD_ECOLI pepdigest swissprot:TRMD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRMD_ECOLI pepinfo swissprot:TRMD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRMD_ECOLI pepnet swissprot:TRMD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRMD_ECOLI pepstats swissprot:TRMD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRMD_ECOLI pepwheel swissprot:TRMD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRMD_ECOLI pepwindow swissprot:TRMD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRMD_ECOLI sigcleave swissprot:TRMD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRMD_ECOLI ## Database ID URL or Descriptions # AltName RATA_ECOLI Toxin RatA # BioGrid 4263441 11 # DISRUPTION PHENOTYPE Deletion of the ratA-ratB operon has no effect on bacterial persistence on rich medium for this strain, but does affect bacterial persistence for E.coli strain CFT073. {ECO:0000269|PubMed 23055930}. # EcoGene EG13193 ratA # FUNCTION RATA_ECOLI Low level expression in a deletion mutant increases resistance to acidified sodium nitrate which causes nitrosative stress. # FUNCTION RATA_ECOLI Toxic component of a toxin-antitoxin (TA) module. Binds to 50S ribosomal subunits, preventing them from associating with 30S subunits to form 70S ribosomes and reducing polysomes. It does not cause ribosomes to dissociate however. The antibiotic paromomycin blocks the anti-association activity of RatA. Overexpression results in inhibition of growth in liquid cultures, and in a decrease in protein translation. The other gene of this operon, ratB, is not the cognate antitoxin in this strain; in CFT073 however it does fulfill this function. # GO_function GO:0043023 ribosomal large subunit binding; IDA:EcoCyc. # GO_process GO:0045947 negative regulation of translational initiation; IMP:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0008150 biological_process # Gene3D 3.30.530.20 -; 1. # InterPro IPR005031 COQ10_START # InterPro IPR023393 START-like_dom # Organism RATA_ECOLI Escherichia coli (strain K12) # PATRIC 32120637 VBIEscCol129921_2717 # PIR T08632 T08632 # Pfam PF03364 Polyketide_cyc # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RATA_ECOLI Ribosome association toxin RatA # RefSeq NP_417109 NC_000913.3 # SIMILARITY Belongs to the ribosome association toxin RatA family. {ECO 0000305}. # SUBUNIT Associates with 50S ribosomes. {ECO:0000269|PubMed 21323758}. # eggNOG COG2867 LUCA # eggNOG ENOG4108Z1B Bacteria BLAST swissprot:RATA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RATA_ECOLI BioCyc ECOL316407:JW2600-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2600-MONOMER BioCyc EcoCyc:G7358-MONOMER http://biocyc.org/getid?id=EcoCyc:G7358-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.91.20.9223 http://dx.doi.org/10.1073/pnas.91.20.9223 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1365-2958.2010.07506.x http://dx.doi.org/10.1111/j.1365-2958.2010.07506.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.185.22.6600-6608.2003 http://dx.doi.org/10.1128/JB.185.22.6600-6608.2003 DOI 10.1371/journal.ppat.1002954 http://dx.doi.org/10.1371/journal.ppat.1002954 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D12501 http://www.ebi.ac.uk/ena/data/view/D12501 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36840 http://www.ebi.ac.uk/ena/data/view/U36840 EchoBASE EB2985 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2985 EcoGene EG13193 http://www.ecogene.org/geneInfo.php?eg_id=EG13193 EnsemblBacteria AAC75668 http://www.ensemblgenomes.org/id/AAC75668 EnsemblBacteria AAC75668 http://www.ensemblgenomes.org/id/AAC75668 EnsemblBacteria BAA16504 http://www.ensemblgenomes.org/id/BAA16504 EnsemblBacteria BAA16504 http://www.ensemblgenomes.org/id/BAA16504 EnsemblBacteria BAA16504 http://www.ensemblgenomes.org/id/BAA16504 EnsemblBacteria b2619 http://www.ensemblgenomes.org/id/b2619 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0043023 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043023 GO_process GO:0045947 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045947 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.30.530.20 http://www.cathdb.info/version/latest/superfamily/3.30.530.20 GeneID 945614 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945614 HOGENOM HOG000261730 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261730&db=HOGENOM6 InParanoid P0AGL5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGL5 IntAct P0AGL5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AGL5* InterPro IPR005031 http://www.ebi.ac.uk/interpro/entry/IPR005031 InterPro IPR023393 http://www.ebi.ac.uk/interpro/entry/IPR023393 KEGG_Gene ecj:JW2600 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2600 KEGG_Gene eco:b2619 http://www.genome.jp/dbget-bin/www_bget?eco:b2619 OMA LREDACK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LREDACK PSORT swissprot:RATA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RATA_ECOLI PSORT-B swissprot:RATA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RATA_ECOLI PSORT2 swissprot:RATA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RATA_ECOLI Pfam PF03364 http://pfam.xfam.org/family/PF03364 Phobius swissprot:RATA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RATA_ECOLI PhylomeDB P0AGL5 http://phylomedb.org/?seqid=P0AGL5 ProteinModelPortal P0AGL5 http://www.proteinmodelportal.org/query/uniprot/P0AGL5 PubMed 14594833 http://www.ncbi.nlm.nih.gov/pubmed/14594833 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21323758 http://www.ncbi.nlm.nih.gov/pubmed/21323758 PubMed 23055930 http://www.ncbi.nlm.nih.gov/pubmed/23055930 PubMed 7524073 http://www.ncbi.nlm.nih.gov/pubmed/7524073 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417109 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417109 SMR P0AGL5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AGL5 STRING 511145.b2619 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2619&targetmode=cogs UniProtKB RATA_ECOLI http://www.uniprot.org/uniprot/RATA_ECOLI UniProtKB-AC P0AGL5 http://www.uniprot.org/uniprot/P0AGL5 charge swissprot:RATA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RATA_ECOLI eggNOG COG2867 http://eggnogapi.embl.de/nog_data/html/tree/COG2867 eggNOG ENOG4108Z1B http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Z1B epestfind swissprot:RATA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RATA_ECOLI garnier swissprot:RATA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RATA_ECOLI helixturnhelix swissprot:RATA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RATA_ECOLI hmoment swissprot:RATA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RATA_ECOLI iep swissprot:RATA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RATA_ECOLI inforesidue swissprot:RATA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RATA_ECOLI octanol swissprot:RATA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RATA_ECOLI pepcoil swissprot:RATA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RATA_ECOLI pepdigest swissprot:RATA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RATA_ECOLI pepinfo swissprot:RATA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RATA_ECOLI pepnet swissprot:RATA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RATA_ECOLI pepstats swissprot:RATA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RATA_ECOLI pepwheel swissprot:RATA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RATA_ECOLI pepwindow swissprot:RATA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RATA_ECOLI sigcleave swissprot:RATA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RATA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260872 4 # EcoGene EG13583 ykgF # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0019516 lactate oxidation; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.10420 -; 2. # IntAct P77536 26 # InterPro IPR003741 LUD_dom # InterPro IPR004452 4Fe-4S-bd # InterPro IPR009051 Helical_ferredxn # InterPro IPR017896 4Fe4S_Fe-S-bd # InterPro IPR017900 4Fe4S_Fe_S_CS # InterPro IPR024185 FTHF_cligase-like # InterPro IPR024569 4Fe-4S-bd_C # MISCELLANEOUS YKGF_ECOLI The E.coli ykgEFG operon is a clear homolog of the B.subtilis lutABC operon, however it is not able of restoring L- lactate utilization to the B.subtilis mutant for lutABC operon. Thus, ykgEFG operon may contribute to lactate catabolism in E.coli, but under conditions other than those tested, or alternatively, the ykgEFG operon may be responsible for the catabolism of a metabolite other than (but perhaps related to) lactate in E.coli. # Organism YKGF_ECOLI Escherichia coli (strain K12) # PATRIC 32115745 VBIEscCol129921_0315 # PIR C64757 C64757 # PROSITE PS00198 4FE4S_FER_1; 2 # PROSITE PS51379 4FE4S_FER_2; 2 # Pfam PF02589 LUD_dom # Pfam PF11870 DUF3390 # Pfam PF13183 Fer4_8 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YKGF_ECOLI Uncharacterized electron transport protein YkgF # RefSeq NP_414841 NC_000913.3 # RefSeq WP_000023927 NZ_LN832404.1 # SIMILARITY Belongs to the LutB/YkgF family. {ECO 0000305}. # SIMILARITY Contains 2 4Fe-4S ferredoxin-type domains. {ECO:0000255|PROSITE-ProRule PRU00711}. # SUPFAM SSF46548 SSF46548 # TIGRFAMs TIGR00273 TIGR00273 # eggNOG COG1139 LUCA # eggNOG ENOG4107QR9 Bacteria BLAST swissprot:YKGF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YKGF_ECOLI BioCyc ECOL316407:JW0300-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0300-MONOMER BioCyc EcoCyc:G6177-MONOMER http://biocyc.org/getid?id=EcoCyc:G6177-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01464-08 http://dx.doi.org/10.1128/JB.01464-08 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB3353 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3353 EcoGene EG13583 http://www.ecogene.org/geneInfo.php?eg_id=EG13583 EnsemblBacteria AAC73410 http://www.ensemblgenomes.org/id/AAC73410 EnsemblBacteria AAC73410 http://www.ensemblgenomes.org/id/AAC73410 EnsemblBacteria BAE76091 http://www.ensemblgenomes.org/id/BAE76091 EnsemblBacteria BAE76091 http://www.ensemblgenomes.org/id/BAE76091 EnsemblBacteria BAE76091 http://www.ensemblgenomes.org/id/BAE76091 EnsemblBacteria b0307 http://www.ensemblgenomes.org/id/b0307 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0019516 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019516 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.10420 http://www.cathdb.info/version/latest/superfamily/3.40.50.10420 GeneID 944980 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944980 HOGENOM HOG000262102 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000262102&db=HOGENOM6 InParanoid P77536 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77536 IntAct P77536 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77536* InterPro IPR003741 http://www.ebi.ac.uk/interpro/entry/IPR003741 InterPro IPR004452 http://www.ebi.ac.uk/interpro/entry/IPR004452 InterPro IPR009051 http://www.ebi.ac.uk/interpro/entry/IPR009051 InterPro IPR017896 http://www.ebi.ac.uk/interpro/entry/IPR017896 InterPro IPR017900 http://www.ebi.ac.uk/interpro/entry/IPR017900 InterPro IPR024185 http://www.ebi.ac.uk/interpro/entry/IPR024185 InterPro IPR024569 http://www.ebi.ac.uk/interpro/entry/IPR024569 KEGG_Gene ecj:JW0300 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0300 KEGG_Gene eco:b0307 http://www.genome.jp/dbget-bin/www_bget?eco:b0307 OMA YEVCPVA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YEVCPVA PROSITE PS00198 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00198 PROSITE PS51379 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51379 PSORT swissprot:YKGF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YKGF_ECOLI PSORT-B swissprot:YKGF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YKGF_ECOLI PSORT2 swissprot:YKGF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YKGF_ECOLI Pfam PF02589 http://pfam.xfam.org/family/PF02589 Pfam PF11870 http://pfam.xfam.org/family/PF11870 Pfam PF13183 http://pfam.xfam.org/family/PF13183 Phobius swissprot:YKGF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YKGF_ECOLI PhylomeDB P77536 http://phylomedb.org/?seqid=P77536 ProteinModelPortal P77536 http://www.proteinmodelportal.org/query/uniprot/P77536 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19201793 http://www.ncbi.nlm.nih.gov/pubmed/19201793 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414841 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414841 RefSeq WP_000023927 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000023927 SMR P77536 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77536 STRING 511145.b0307 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0307&targetmode=cogs SUPFAM SSF46548 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46548 TIGRFAMs TIGR00273 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00273 UniProtKB YKGF_ECOLI http://www.uniprot.org/uniprot/YKGF_ECOLI UniProtKB-AC P77536 http://www.uniprot.org/uniprot/P77536 charge swissprot:YKGF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YKGF_ECOLI eggNOG COG1139 http://eggnogapi.embl.de/nog_data/html/tree/COG1139 eggNOG ENOG4107QR9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QR9 epestfind swissprot:YKGF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YKGF_ECOLI garnier swissprot:YKGF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YKGF_ECOLI helixturnhelix swissprot:YKGF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YKGF_ECOLI hmoment swissprot:YKGF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YKGF_ECOLI iep swissprot:YKGF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YKGF_ECOLI inforesidue swissprot:YKGF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YKGF_ECOLI octanol swissprot:YKGF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YKGF_ECOLI pepcoil swissprot:YKGF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YKGF_ECOLI pepdigest swissprot:YKGF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YKGF_ECOLI pepinfo swissprot:YKGF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YKGF_ECOLI pepnet swissprot:YKGF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YKGF_ECOLI pepstats swissprot:YKGF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YKGF_ECOLI pepwheel swissprot:YKGF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YKGF_ECOLI pepwindow swissprot:YKGF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YKGF_ECOLI sigcleave swissprot:YKGF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YKGF_ECOLI ## Database ID URL or Descriptions # BioGrid 4262565 94 # EcoGene EG10886 rpmB # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0022625 cytosolic large ribosomal subunit; IDA:EcoCyc. # GO_function GO:0003735 structural constituent of ribosome; IBA:GO_Central. # GO_process GO:0006412 translation; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_process GO:0006412 translation # HAMAP MF_00373 Ribosomal_L28 # INTERACTION RL28_ECOLI P0A7N4 rpmF; NbExp=2; IntAct=EBI-543024, EBI-1112732; # IntAct P0A7M2 113 # InterPro IPR001383 Ribosomal_L28 # InterPro IPR026569 Ribo_L28/L24 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=8875.0; Method=MALDI; Range=2-78; Evidence={ECO:0000269|PubMed 10094780}; # Organism RL28_ECOLI Escherichia coli (strain K12) # PANTHER PTHR13528 PTHR13528 # PATRIC 32122761 VBIEscCol129921_3757 # PDB 3J5L EM; 6.60 A; X=2-78 # PDB 3J7Z EM; 3.90 A; X=1-78 # PDB 3J8G EM; 5.00 A; 0=1-78 # PDB 3J9Y EM; 3.90 A; X=1-78 # PDB 3J9Z EM; 3.60 A; LV=2-78 # PDB 3JA1 EM; 3.60 A; LZ=2-78 # PDB 3JBU EM; 3.64 A; 0=1-78 # PDB 3JBV EM; 3.32 A; 0=1-78 # PDB 3JCD EM; 3.70 A; X=1-78 # PDB 3JCE EM; 3.20 A; X=1-78 # PDB 3JCJ EM; 3.70 A; W=1-78 # PDB 3JCN EM; 4.60 A; X=1-78 # PDB 4CSU EM; 5.50 A; 0=2-78 # PDB 4U1U X-ray; 2.95 A; BX/DX=2-78 # PDB 4U1V X-ray; 3.00 A; BX/DX=2-78 # PDB 4U20 X-ray; 2.90 A; BX/DX=2-78 # PDB 4U24 X-ray; 2.90 A; BX/DX=2-78 # PDB 4U25 X-ray; 2.90 A; BX/DX=2-78 # PDB 4U26 X-ray; 2.80 A; BX/DX=2-78 # PDB 4U27 X-ray; 2.80 A; BX/DX=2-78 # PDB 4UY8 EM; 3.80 A; X=2-78 # PDB 4V50 X-ray; 3.22 A; BX/DX=2-78 # PDB 4V52 X-ray; 3.21 A; BZ/DZ=1-78 # PDB 4V53 X-ray; 3.54 A; BZ/DZ=1-78 # PDB 4V54 X-ray; 3.30 A; BZ/DZ=1-78 # PDB 4V55 X-ray; 4.00 A; BZ/DZ=1-78 # PDB 4V56 X-ray; 3.93 A; BZ/DZ=1-78 # PDB 4V57 X-ray; 3.50 A; BZ/DZ=1-78 # PDB 4V5H EM; 5.80 A; B0=2-78 # PDB 4V5Y X-ray; 4.45 A; BZ/DZ=1-78 # PDB 4V64 X-ray; 3.50 A; BZ/DZ=1-78 # PDB 4V69 EM; 6.70 A; BX=2-78 # PDB 4V6C X-ray; 3.19 A; BX/DX=1-78 # PDB 4V6D X-ray; 3.81 A; BX/DX=1-78 # PDB 4V6E X-ray; 3.71 A; BX/DX=1-78 # PDB 4V6K EM; 8.25 A; AY=1-78 # PDB 4V6L EM; 13.20 A; BY=1-78 # PDB 4V6M EM; 7.10 A; BX=2-78 # PDB 4V6N EM; 12.10 A; AZ=2-78 # PDB 4V6O EM; 14.70 A; BZ=2-78 # PDB 4V6P EM; 13.50 A; BZ=2-78 # PDB 4V6Q EM; 11.50 A; BZ=2-78 # PDB 4V6R EM; 11.50 A; BZ=2-78 # PDB 4V6S EM; 13.10 A; AZ=2-78 # PDB 4V6T EM; 8.30 A; BX=2-78 # PDB 4V6V EM; 9.80 A; B1=2-78 # PDB 4V6Y EM; 12.00 A; BX=1-78 # PDB 4V6Z EM; 12.00 A; BX=1-78 # PDB 4V70 EM; 17.00 A; BX=1-78 # PDB 4V71 EM; 20.00 A; BX=1-78 # PDB 4V72 EM; 13.00 A; BX=1-78 # PDB 4V73 EM; 15.00 A; BX=1-78 # PDB 4V74 EM; 17.00 A; BX=1-78 # PDB 4V75 EM; 12.00 A; BX=1-78 # PDB 4V76 EM; 17.00 A; BX=1-78 # PDB 4V77 EM; 17.00 A; BX=1-78 # PDB 4V78 EM; 20.00 A; BX=1-78 # PDB 4V79 EM; 15.00 A; BX=1-78 # PDB 4V7A EM; 9.00 A; BX=1-78 # PDB 4V7B EM; 6.80 A; BX=1-78 # PDB 4V7C EM; 7.60 A; BZ=2-78 # PDB 4V7D EM; 7.60 A; A1=2-78 # PDB 4V7I EM; 9.60 A; AX=1-78 # PDB 4V7S X-ray; 3.25 A; BX/DX=2-78 # PDB 4V7T X-ray; 3.19 A; BX/DX=2-78 # PDB 4V7U X-ray; 3.10 A; BX/DX=2-78 # PDB 4V7V X-ray; 3.29 A; BX/DX=2-78 # PDB 4V85 X-ray; 3.20 A; 1=1-78 # PDB 4V89 X-ray; 3.70 A; B1=1-78 # PDB 4V9C X-ray; 3.30 A; BX/DX=1-78 # PDB 4V9D X-ray; 3.00 A; CX/DX=2-78 # PDB 4V9O X-ray; 2.90 A; AX/CX/EX/GX=1-78 # PDB 4V9P X-ray; 2.90 A; AX/CX/EX/GX=1-78 # PDB 4WF1 X-ray; 3.09 A; BX/DX=2-78 # PDB 4WOI X-ray; 3.00 A; BX/CX=1-78 # PDB 4WWW X-ray; 3.10 A; RX/YX=2-78 # PDB 4YBB X-ray; 2.10 A; CY/DY=2-78 # PDB 5ADY EM; 4.50 A; X=1-78 # PDB 5AFI EM; 2.90 A; X=1-78 # PDB 5GAD EM; 3.70 A; Y=1-78 # PDB 5GAE EM; 3.33 A; Y=1-78 # PDB 5GAF EM; 4.30 A; Y=2-78 # PDB 5GAG EM; 3.80 A; Y=1-78 # PDB 5GAH EM; 3.80 A; Y=1-78 # PDB 5IQR EM; 3.00 A; X=1-78 # PDB 5IT8 X-ray; 3.12 A; CY/DY=2-78 # PDB 5J5B X-ray; 2.80 A; CY/DY=2-78 # PDB 5J7L X-ray; 3.00 A; CY/DY=2-78 # PDB 5J88 X-ray; 3.32 A; CY/DY=2-78 # PDB 5J8A X-ray; 3.10 A; CY/DY=2-78 # PDB 5J91 X-ray; 2.96 A; CY/DY=2-78 # PDB 5JC9 X-ray; 3.03 A; CY/DY=2-78 # PDB 5JTE EM; 3.60 A; BX=1-78 # PDB 5JU8 EM; 3.60 A; BX=1-78 # PDB 5KCR EM; 3.60 A; 11=1-78 # PDB 5KCS EM; 3.90 A; 11=1-78 # PDB 5KPS EM; 3.90 A; X=1-78 # PDB 5KPV EM; 4.10 A; W=1-78 # PDB 5KPW EM; 3.90 A; W=1-78 # PDB 5KPX EM; 3.90 A; W=1-78 # PDB 5L3P EM; 3.70 A; 1=1-78 # PIR S42443 R5EC28 # Pfam PF00830 Ribosomal_L28 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RL28_ECOLI 50S ribosomal protein L28 # RefSeq NP_418094 NC_000913.3 # RefSeq WP_000091955 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein L28P family. {ECO 0000305}. # TIGRFAMs TIGR00009 L28 # eggNOG COG0227 LUCA # eggNOG ENOG4105KDC Bacteria BLAST swissprot:RL28_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RL28_ECOLI BioCyc ECOL316407:JW3612-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3612-MONOMER BioCyc EcoCyc:EG10886-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10886-MONOMER BioCyc MetaCyc:EG10886-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10886-MONOMER COG COG0227 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0227 DIP DIP-35745N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35745N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1016/0014-5793(77)80960-5 http://dx.doi.org/10.1016/0014-5793(77)80960-5 DOI 10.1016/j.celrep.2014.09.011 http://dx.doi.org/10.1016/j.celrep.2014.09.011 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pbio.1001866 http://dx.doi.org/10.1371/journal.pbio.1001866 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01677 http://www.ebi.ac.uk/ena/data/view/J01677 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0879 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0879 EcoGene EG10886 http://www.ecogene.org/geneInfo.php?eg_id=EG10886 EnsemblBacteria AAC76661 http://www.ensemblgenomes.org/id/AAC76661 EnsemblBacteria AAC76661 http://www.ensemblgenomes.org/id/AAC76661 EnsemblBacteria BAE77655 http://www.ensemblgenomes.org/id/BAE77655 EnsemblBacteria BAE77655 http://www.ensemblgenomes.org/id/BAE77655 EnsemblBacteria BAE77655 http://www.ensemblgenomes.org/id/BAE77655 EnsemblBacteria b3637 http://www.ensemblgenomes.org/id/b3637 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0022625 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022625 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GeneID 946941 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946941 HAMAP MF_00373 http://hamap.expasy.org/unirule/MF_00373 HOGENOM HOG000040462 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000040462&db=HOGENOM6 InParanoid P0A7M2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7M2 IntAct P0A7M2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7M2* InterPro IPR001383 http://www.ebi.ac.uk/interpro/entry/IPR001383 InterPro IPR026569 http://www.ebi.ac.uk/interpro/entry/IPR026569 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW3612 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3612 KEGG_Gene eco:b3637 http://www.genome.jp/dbget-bin/www_bget?eco:b3637 KEGG_Orthology KO:K02902 http://www.genome.jp/dbget-bin/www_bget?KO:K02902 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 MINT MINT-1306660 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1306660 OMA WLPSERR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WLPSERR PANTHER PTHR13528 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13528 PDB 3J5L http://www.ebi.ac.uk/pdbe-srv/view/entry/3J5L PDB 3J7Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J7Z PDB 3J8G http://www.ebi.ac.uk/pdbe-srv/view/entry/3J8G PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 4CSU http://www.ebi.ac.uk/pdbe-srv/view/entry/4CSU PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4UY8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4UY8 PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5ADY http://www.ebi.ac.uk/pdbe-srv/view/entry/5ADY PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5GAD http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAD PDB 5GAE http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAE PDB 5GAF http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAF PDB 5GAG http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAG PDB 5GAH http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAH PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 3J5L http://www.ebi.ac.uk/pdbsum/3J5L PDBsum 3J7Z http://www.ebi.ac.uk/pdbsum/3J7Z PDBsum 3J8G http://www.ebi.ac.uk/pdbsum/3J8G PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 4CSU http://www.ebi.ac.uk/pdbsum/4CSU PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4UY8 http://www.ebi.ac.uk/pdbsum/4UY8 PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5ADY http://www.ebi.ac.uk/pdbsum/5ADY PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5GAD http://www.ebi.ac.uk/pdbsum/5GAD PDBsum 5GAE http://www.ebi.ac.uk/pdbsum/5GAE PDBsum 5GAF http://www.ebi.ac.uk/pdbsum/5GAF PDBsum 5GAG http://www.ebi.ac.uk/pdbsum/5GAG PDBsum 5GAH http://www.ebi.ac.uk/pdbsum/5GAH PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PSORT swissprot:RL28_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RL28_ECOLI PSORT-B swissprot:RL28_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RL28_ECOLI PSORT2 swissprot:RL28_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RL28_ECOLI Pfam PF00830 http://pfam.xfam.org/family/PF00830 Phobius swissprot:RL28_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RL28_ECOLI PhylomeDB P0A7M2 http://phylomedb.org/?seqid=P0A7M2 ProteinModelPortal P0A7M2 http://www.proteinmodelportal.org/query/uniprot/P0A7M2 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 24844575 http://www.ncbi.nlm.nih.gov/pubmed/24844575 PubMed 25310980 http://www.ncbi.nlm.nih.gov/pubmed/25310980 PubMed 332524 http://www.ncbi.nlm.nih.gov/pubmed/332524 PubMed 7035835 http://www.ncbi.nlm.nih.gov/pubmed/7035835 PubMed 7556101 http://www.ncbi.nlm.nih.gov/pubmed/7556101 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_418094 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418094 RefSeq WP_000091955 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000091955 SMR P0A7M2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7M2 STRING 511145.b3637 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3637&targetmode=cogs STRING COG0227 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0227&targetmode=cogs TIGRFAMs TIGR00009 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00009 UniProtKB RL28_ECOLI http://www.uniprot.org/uniprot/RL28_ECOLI UniProtKB-AC P0A7M2 http://www.uniprot.org/uniprot/P0A7M2 charge swissprot:RL28_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RL28_ECOLI eggNOG COG0227 http://eggnogapi.embl.de/nog_data/html/tree/COG0227 eggNOG ENOG4105KDC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KDC epestfind swissprot:RL28_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RL28_ECOLI garnier swissprot:RL28_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RL28_ECOLI helixturnhelix swissprot:RL28_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RL28_ECOLI hmoment swissprot:RL28_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RL28_ECOLI iep swissprot:RL28_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RL28_ECOLI inforesidue swissprot:RL28_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RL28_ECOLI octanol swissprot:RL28_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RL28_ECOLI pepcoil swissprot:RL28_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RL28_ECOLI pepdigest swissprot:RL28_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RL28_ECOLI pepinfo swissprot:RL28_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RL28_ECOLI pepnet swissprot:RL28_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RL28_ECOLI pepstats swissprot:RL28_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RL28_ECOLI pepwheel swissprot:RL28_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RL28_ECOLI pepwindow swissprot:RL28_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RL28_ECOLI sigcleave swissprot:RL28_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RL28_ECOLI ## Database ID URL or Descriptions # FUNCTION PSIA1_ECOLI Not yet known. # InterPro IPR009713 Uncharacterised_PsiA # Organism PSIA1_ECOLI Escherichia coli (strain K12) # Pfam PF06952 PsiA # RecName PSIA1_ECOLI Protein PsiA # RefSeq NP_061443 NC_002483.1 # RefSeq WP_000116348 NZ_CP014273.1 # RefSeq YP_190155 NC_006671.1 # RefSeq YP_443990 NC_007675.1 # SIMILARITY To PsiA protein of plasmid R6-5. {ECO 0000305}. BLAST swissprot:PSIA1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PSIA1_ECOLI DOI 10.1093/nar/18.15.4597 http://dx.doi.org/10.1093/nar/18.15.4597 EMBL AF106329 http://www.ebi.ac.uk/ena/data/view/AF106329 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1263537 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263537 GeneID 3244852 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3244852 GeneID 3853429 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3853429 InterPro IPR009713 http://www.ebi.ac.uk/interpro/entry/IPR009713 OMA LQWLYAV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LQWLYAV PSORT swissprot:PSIA1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PSIA1_ECOLI PSORT-B swissprot:PSIA1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PSIA1_ECOLI PSORT2 swissprot:PSIA1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PSIA1_ECOLI Pfam PF06952 http://pfam.xfam.org/family/PF06952 Phobius swissprot:PSIA1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PSIA1_ECOLI ProteinModelPortal P18148 http://www.proteinmodelportal.org/query/uniprot/P18148 PubMed 2201950 http://www.ncbi.nlm.nih.gov/pubmed/2201950 RefSeq NP_061443 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061443 RefSeq WP_000116348 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000116348 RefSeq YP_190155 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_190155 RefSeq YP_443990 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_443990 UniProtKB PSIA1_ECOLI http://www.uniprot.org/uniprot/PSIA1_ECOLI UniProtKB-AC P18148 http://www.uniprot.org/uniprot/P18148 charge swissprot:PSIA1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PSIA1_ECOLI epestfind swissprot:PSIA1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PSIA1_ECOLI garnier swissprot:PSIA1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PSIA1_ECOLI helixturnhelix swissprot:PSIA1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PSIA1_ECOLI hmoment swissprot:PSIA1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PSIA1_ECOLI iep swissprot:PSIA1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PSIA1_ECOLI inforesidue swissprot:PSIA1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PSIA1_ECOLI octanol swissprot:PSIA1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PSIA1_ECOLI pepcoil swissprot:PSIA1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PSIA1_ECOLI pepdigest swissprot:PSIA1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PSIA1_ECOLI pepinfo swissprot:PSIA1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PSIA1_ECOLI pepnet swissprot:PSIA1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PSIA1_ECOLI pepstats swissprot:PSIA1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PSIA1_ECOLI pepwheel swissprot:PSIA1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PSIA1_ECOLI pepwindow swissprot:PSIA1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PSIA1_ECOLI sigcleave swissprot:PSIA1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PSIA1_ECOLI ## Database ID URL or Descriptions # EcoGene EG12869 ybfK # Organism YBFK_ECOLI Escherichia coli (strain K12) # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBFK_ECOLI Uncharacterized protein YbfK # RefSeq WP_001171592 NZ_LN832404.1 # RefSeq YP_001165310 NC_000913.3 BLAST swissprot:YBFK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBFK_ECOLI BioCyc EcoCyc:MONOMER0-2815 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2815 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M64495 http://www.ebi.ac.uk/ena/data/view/M64495 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2710 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2710 EcoGene EG12869 http://www.ecogene.org/geneInfo.php?eg_id=EG12869 EnsemblBacteria ABP93437 http://www.ensemblgenomes.org/id/ABP93437 EnsemblBacteria ABP93437 http://www.ensemblgenomes.org/id/ABP93437 EnsemblBacteria b4590 http://www.ensemblgenomes.org/id/b4590 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 948953 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948953 HOGENOM HOG000081489 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000081489&db=HOGENOM6 KEGG_Gene eco:b4590 http://www.genome.jp/dbget-bin/www_bget?eco:b4590 PSORT swissprot:YBFK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBFK_ECOLI PSORT-B swissprot:YBFK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBFK_ECOLI PSORT2 swissprot:YBFK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBFK_ECOLI Phobius swissprot:YBFK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBFK_ECOLI ProteinModelPortal P46121 http://www.proteinmodelportal.org/query/uniprot/P46121 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1939141 http://www.ncbi.nlm.nih.gov/pubmed/1939141 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001171592 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001171592 RefSeq YP_001165310 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001165310 STRING 511145.b4590 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4590&targetmode=cogs UniProtKB YBFK_ECOLI http://www.uniprot.org/uniprot/YBFK_ECOLI UniProtKB-AC P46121 http://www.uniprot.org/uniprot/P46121 charge swissprot:YBFK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBFK_ECOLI epestfind swissprot:YBFK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBFK_ECOLI garnier swissprot:YBFK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBFK_ECOLI helixturnhelix swissprot:YBFK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBFK_ECOLI hmoment swissprot:YBFK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBFK_ECOLI iep swissprot:YBFK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBFK_ECOLI inforesidue swissprot:YBFK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBFK_ECOLI octanol swissprot:YBFK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBFK_ECOLI pepcoil swissprot:YBFK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBFK_ECOLI pepdigest swissprot:YBFK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBFK_ECOLI pepinfo swissprot:YBFK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBFK_ECOLI pepnet swissprot:YBFK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBFK_ECOLI pepstats swissprot:YBFK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBFK_ECOLI pepwheel swissprot:YBFK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBFK_ECOLI pepwindow swissprot:YBFK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBFK_ECOLI sigcleave swissprot:YBFK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBFK_ECOLI ## Database ID URL or Descriptions # Organism YUAC_ECOLI Escherichia coli (strain K12) # RecName YUAC_ECOLI Uncharacterized protein YuaC # RefSeq NP_061391 NC_002483.1 # RefSeq WP_001351580 NZ_CP014273.1 BLAST swissprot:YUAC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YUAC_ECOLI EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1263533 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263533 PSORT swissprot:YUAC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YUAC_ECOLI PSORT-B swissprot:YUAC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YUAC_ECOLI PSORT2 swissprot:YUAC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YUAC_ECOLI Phobius swissprot:YUAC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YUAC_ECOLI ProteinModelPortal Q9JMT7 http://www.proteinmodelportal.org/query/uniprot/Q9JMT7 RefSeq NP_061391 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061391 RefSeq WP_001351580 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001351580 UniProtKB YUAC_ECOLI http://www.uniprot.org/uniprot/YUAC_ECOLI UniProtKB-AC Q9JMT7 http://www.uniprot.org/uniprot/Q9JMT7 charge swissprot:YUAC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YUAC_ECOLI epestfind swissprot:YUAC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YUAC_ECOLI garnier swissprot:YUAC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YUAC_ECOLI helixturnhelix swissprot:YUAC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YUAC_ECOLI hmoment swissprot:YUAC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YUAC_ECOLI iep swissprot:YUAC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YUAC_ECOLI inforesidue swissprot:YUAC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YUAC_ECOLI octanol swissprot:YUAC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YUAC_ECOLI pepcoil swissprot:YUAC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YUAC_ECOLI pepdigest swissprot:YUAC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YUAC_ECOLI pepinfo swissprot:YUAC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YUAC_ECOLI pepnet swissprot:YUAC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YUAC_ECOLI pepstats swissprot:YUAC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YUAC_ECOLI pepwheel swissprot:YUAC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YUAC_ECOLI pepwindow swissprot:YUAC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YUAC_ECOLI sigcleave swissprot:YUAC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YUAC_ECOLI ## Database ID URL or Descriptions # BioGrid 4259327 4 # DOMAIN MODE_ECOLI Contains two major domains the N-terminal domain I forms a winged helix-turn-helix motif and interacts with DNA. The C- terminal domain II is the putative molybdate-binding component and contains a tandem repeat of the Mop domain, each of which forms a beta-barrel. The N-terminal domain plays a major role in the dimerization of the protein whereas the C-terminal domain contributes to the stability of the complex. # EcoGene EG13227 modE # FUNCTION MODE_ECOLI The ModE-Mo complex acts as a repressor of the modABC operon, involved in the transport of molybdate. Upon binding molybdate, the conformation of the protein changes, promoting dimerization of ModE-Mo. The protein dimer is then competent to bind a DNA region, upstream of the modABC operon, which contains an 8-base inverted repeat 5'-TAACGTTA-3' flanked by two CAT boxes. Acts also as an enhancer of the expression of genes coding for molybdoenzymes, both directly and indirectly. ModE also interacts with tungstate. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_function GO:0030151 molybdenum ion binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0015689 molybdate ion transport; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR003725 ModE-bd_N # InterPro IPR004606 Mo-pterin-bd # InterPro IPR005116 Transp-assoc_OB_typ1 # InterPro IPR008995 Mo/tungstate-bd_C_term_dom # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR016462 ModE # KEGG_Brite ko03000 Transcription factors # MASS SPECTROMETRY Mass=28271; Method=MALDI; Range=1-262; Evidence={ECO:0000269|PubMed 8550508}; # Organism MODE_ECOLI Escherichia coli (strain K12) # PATRIC 32116723 VBIEscCol129921_0787 # PDB 1B9M X-ray; 1.75 A; A/B=1-262 # PDB 1B9N X-ray; 2.09 A; A/B=1-262 # PDB 1H9R X-ray; 1.90 A; A/B=124-262 # PDB 1H9S X-ray; 1.82 A; A/B=124-262 # PDB 1O7L X-ray; 2.75 A; A/B/C/D=1-262 # PIR JC6037 JC6037 # PIRSF PIRSF005763 Txn_reg_ModE # Pfam PF00126 HTH_1 # Pfam PF03459 TOBE; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MODE_ECOLI Transcriptional regulator ModE # RefSeq NP_415282 NC_000913.3 # RefSeq WP_001147439 NZ_LN832404.1 # SIMILARITY Belongs to the ModE family. {ECO 0000305}. # SUBCELLULAR LOCATION MODE_ECOLI Cytoplasm. # SUBUNIT MODE_ECOLI Homodimer. # SUPFAM SSF46785 SSF46785 # SUPFAM SSF50331 SSF50331; 2 # TIGRFAMs TIGR00637 ModE_repress # TIGRFAMs TIGR00638 Mop # eggNOG COG2005 LUCA # eggNOG ENOG4105F4R Bacteria BLAST swissprot:MODE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MODE_ECOLI BioCyc ECOL316407:JW0744-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0744-MONOMER BioCyc EcoCyc:MONOMER0-185 http://biocyc.org/getid?id=EcoCyc:MONOMER0-185 COG COG2005 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2005 DIP DIP-10238N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10238N DOI 10.1016/S0923-2508(01)01202-5 http://dx.doi.org/10.1016/S0923-2508(01)01202-5 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/emboj/18.6.1435 http://dx.doi.org/10.1093/emboj/18.6.1435 DOI 10.1111/j.1432-1033.1997.00119.x http://dx.doi.org/10.1111/j.1432-1033.1997.00119.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U07867 http://www.ebi.ac.uk/ena/data/view/U07867 EMBL U27192 http://www.ebi.ac.uk/ena/data/view/U27192 EMBL U34275 http://www.ebi.ac.uk/ena/data/view/U34275 EchoBASE EB3017 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3017 EcoGene EG13227 http://www.ecogene.org/geneInfo.php?eg_id=EG13227 EnsemblBacteria AAC73848 http://www.ensemblgenomes.org/id/AAC73848 EnsemblBacteria AAC73848 http://www.ensemblgenomes.org/id/AAC73848 EnsemblBacteria BAA35425 http://www.ensemblgenomes.org/id/BAA35425 EnsemblBacteria BAA35425 http://www.ensemblgenomes.org/id/BAA35425 EnsemblBacteria BAA35425 http://www.ensemblgenomes.org/id/BAA35425 EnsemblBacteria b0761 http://www.ensemblgenomes.org/id/b0761 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0030151 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030151 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0015689 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015689 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 945366 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945366 HOGENOM HOG000156225 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000156225&db=HOGENOM6 InParanoid P0A9G8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9G8 IntAct P0A9G8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9G8* InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR003725 http://www.ebi.ac.uk/interpro/entry/IPR003725 InterPro IPR004606 http://www.ebi.ac.uk/interpro/entry/IPR004606 InterPro IPR005116 http://www.ebi.ac.uk/interpro/entry/IPR005116 InterPro IPR008995 http://www.ebi.ac.uk/interpro/entry/IPR008995 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR016462 http://www.ebi.ac.uk/interpro/entry/IPR016462 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW0744 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0744 KEGG_Gene eco:b0761 http://www.genome.jp/dbget-bin/www_bget?eco:b0761 KEGG_Orthology KO:K02019 http://www.genome.jp/dbget-bin/www_bget?KO:K02019 OMA SYKTAWH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SYKTAWH PDB 1B9M http://www.ebi.ac.uk/pdbe-srv/view/entry/1B9M PDB 1B9N http://www.ebi.ac.uk/pdbe-srv/view/entry/1B9N PDB 1H9R http://www.ebi.ac.uk/pdbe-srv/view/entry/1H9R PDB 1H9S http://www.ebi.ac.uk/pdbe-srv/view/entry/1H9S PDB 1O7L http://www.ebi.ac.uk/pdbe-srv/view/entry/1O7L PDBsum 1B9M http://www.ebi.ac.uk/pdbsum/1B9M PDBsum 1B9N http://www.ebi.ac.uk/pdbsum/1B9N PDBsum 1H9R http://www.ebi.ac.uk/pdbsum/1H9R PDBsum 1H9S http://www.ebi.ac.uk/pdbsum/1H9S PDBsum 1O7L http://www.ebi.ac.uk/pdbsum/1O7L PSORT swissprot:MODE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MODE_ECOLI PSORT-B swissprot:MODE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MODE_ECOLI PSORT2 swissprot:MODE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MODE_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03459 http://pfam.xfam.org/family/PF03459 Phobius swissprot:MODE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MODE_ECOLI PhylomeDB P0A9G8 http://phylomedb.org/?seqid=P0A9G8 ProteinModelPortal P0A9G8 http://www.proteinmodelportal.org/query/uniprot/P0A9G8 PubMed 10075916 http://www.ncbi.nlm.nih.gov/pubmed/10075916 PubMed 11421278 http://www.ncbi.nlm.nih.gov/pubmed/11421278 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8550508 http://www.ncbi.nlm.nih.gov/pubmed/8550508 PubMed 8564363 http://www.ncbi.nlm.nih.gov/pubmed/8564363 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9210473 http://www.ncbi.nlm.nih.gov/pubmed/9210473 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415282 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415282 RefSeq WP_001147439 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001147439 SMR P0A9G8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9G8 STRING 511145.b0761 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0761&targetmode=cogs STRING COG2005 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2005&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SUPFAM SSF50331 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50331 TIGRFAMs TIGR00637 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00637 TIGRFAMs TIGR00638 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00638 UniProtKB MODE_ECOLI http://www.uniprot.org/uniprot/MODE_ECOLI UniProtKB-AC P0A9G8 http://www.uniprot.org/uniprot/P0A9G8 charge swissprot:MODE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MODE_ECOLI eggNOG COG2005 http://eggnogapi.embl.de/nog_data/html/tree/COG2005 eggNOG ENOG4105F4R http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F4R epestfind swissprot:MODE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MODE_ECOLI garnier swissprot:MODE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MODE_ECOLI helixturnhelix swissprot:MODE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MODE_ECOLI hmoment swissprot:MODE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MODE_ECOLI iep swissprot:MODE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MODE_ECOLI inforesidue swissprot:MODE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MODE_ECOLI octanol swissprot:MODE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MODE_ECOLI pepcoil swissprot:MODE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MODE_ECOLI pepdigest swissprot:MODE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MODE_ECOLI pepinfo swissprot:MODE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MODE_ECOLI pepnet swissprot:MODE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MODE_ECOLI pepstats swissprot:MODE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MODE_ECOLI pepwheel swissprot:MODE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MODE_ECOLI pepwindow swissprot:MODE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MODE_ECOLI sigcleave swissprot:MODE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MODE_ECOLI ## Database ID URL or Descriptions # EcoGene EG10868 rplE # FUNCTION RL5_ECOLI Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome- bound tRNAs. {ECO 0000269|PubMed 8524654}. # FUNCTION RL5_ECOLI In the 70S ribosome in the initiation state (PubMed 12809609) was modeled to contact protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; the protein- protein contacts between S13 and L5 in B1b change in the model with bound EF-G implicating this bridge in subunit movement (PubMed 12809609 and PubMed 18723842). In the two 3.5 A resolved ribosome structures (PubMed 16272117) the contacts between L5, S13 and S19 are different, confirming the dynamic nature of this interaction. {ECO 0000269|PubMed 12809609, ECO 0000269|PubMed 12859903, ECO 0000269|PubMed 16272117}. # FUNCTION RL5_ECOLI This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. Its 5S rRNA binding is significantly enhanced in the presence of L18. {ECO 0000269|PubMed 354687, ECO 0000269|PubMed 7038683, ECO 0000269|PubMed 8925931}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0022625 cytosolic large ribosomal subunit; IDA:EcoCyc. # GO_function GO:0000049 tRNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0003735 structural constituent of ribosome; IBA:GO_Central. # GO_function GO:0008097 5S rRNA binding; IDA:EcoCyc. # GO_process GO:0000027 ribosomal large subunit assembly; IMP:EcoCyc. # GO_process GO:0006412 translation; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_function GO:0019843 rRNA binding # GOslim_process GO:0006412 translation # GOslim_process GO:0022618 ribonucleoprotein complex assembly # Gene3D 3.30.1440.10 -; 1. # HAMAP MF_01333_B Ribosomal_L5_B # IntAct P62399 71 # InterPro IPR002132 Ribosomal_L5 # InterPro IPR020929 Ribosomal_L5_CS # InterPro IPR020930 Ribosomal_L5_bac-type # InterPro IPR022803 Ribosomal_L5_domain # InterPro IPR031309 Ribosomal_L5_C # InterPro IPR031310 Ribosomal_L5_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 M00179 Ribosome, archaea # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=20169.8; Method=MALDI; Range=2-179; Evidence={ECO:0000269|PubMed 10094780}; # Organism RL5_ECOLI Escherichia coli (strain K12) # PATRIC 32122048 VBIEscCol129921_3401 # PDB 1ML5 EM; 14.00 A; g=2-177 # PDB 2J28 EM; 8.00 A; F=2-179 # PDB 2RDO EM; 9.10 A; F=2-179 # PDB 3BBX EM; 10.00 A; F=2-179 # PDB 3J5L EM; 6.60 A; F=2-178 # PDB 3J5S EM; 7.50 A; G=2-179 # PDB 3J7Z EM; 3.90 A; F=1-179 # PDB 3J8G EM; 5.00 A; F=1-179 # PDB 3J9Y EM; 3.90 A; F=1-179 # PDB 3J9Z EM; 3.60 A; L7=2-179 # PDB 3JA1 EM; 3.60 A; LG=2-179 # PDB 3JBU EM; 3.64 A; f=1-179 # PDB 3JBV EM; 3.32 A; f=1-179 # PDB 3JCD EM; 3.70 A; F=1-179 # PDB 3JCE EM; 3.20 A; F=1-179 # PDB 3JCJ EM; 3.70 A; E=1-179 # PDB 3JCN EM; 4.60 A; F=1-179 # PDB 4CSU EM; 5.50 A; F=2-179 # PDB 4U1U X-ray; 2.95 A; BF/DF=2-178 # PDB 4U1V X-ray; 3.00 A; BF/DF=2-178 # PDB 4U20 X-ray; 2.90 A; BF/DF=2-178 # PDB 4U24 X-ray; 2.90 A; BF/DF=2-178 # PDB 4U25 X-ray; 2.90 A; BF/DF=2-178 # PDB 4U26 X-ray; 2.80 A; BF/DF=2-178 # PDB 4U27 X-ray; 2.80 A; BF/DF=2-178 # PDB 4UY8 EM; 3.80 A; F=2-178 # PDB 4V47 EM; 12.30 A; AD=2-179 # PDB 4V48 EM; 11.50 A; AD=2-179 # PDB 4V4H X-ray; 3.46 A; BF/DF=1-179 # PDB 4V4Q X-ray; 3.46 A; BF/DF=2-179 # PDB 4V4V EM; 15.00 A; BD=3-179 # PDB 4V4W EM; 15.00 A; BD=3-179 # PDB 4V50 X-ray; 3.22 A; BF/DF=2-179 # PDB 4V52 X-ray; 3.21 A; BF/DF=2-179 # PDB 4V53 X-ray; 3.54 A; BF/DF=2-179 # PDB 4V54 X-ray; 3.30 A; BF/DF=2-179 # PDB 4V55 X-ray; 4.00 A; BF/DF=2-179 # PDB 4V56 X-ray; 3.93 A; BF/DF=2-179 # PDB 4V57 X-ray; 3.50 A; BF/DF=2-179 # PDB 4V5B X-ray; 3.74 A; AF/CF=2-179 # PDB 4V5H EM; 5.80 A; BF=2-179 # PDB 4V5Y X-ray; 4.45 A; BF/DF=2-179 # PDB 4V64 X-ray; 3.50 A; BF/DF=2-179 # PDB 4V65 EM; 9.00 A; B2=2-179 # PDB 4V66 EM; 9.00 A; B2=2-179 # PDB 4V69 EM; 6.70 A; BF=2-179 # PDB 4V6C X-ray; 3.19 A; BF/DF=1-179 # PDB 4V6D X-ray; 3.81 A; BF/DF=1-179 # PDB 4V6E X-ray; 3.71 A; BF/DF=1-179 # PDB 4V6K EM; 8.25 A; AG=1-179 # PDB 4V6L EM; 13.20 A; BG=1-179 # PDB 4V6M EM; 7.10 A; BF=2-179 # PDB 4V6N EM; 12.10 A; AG=2-179 # PDB 4V6O EM; 14.70 A; BG=2-179 # PDB 4V6P EM; 13.50 A; BG=2-179 # PDB 4V6Q EM; 11.50 A; BG=2-179 # PDB 4V6R EM; 11.50 A; BG=2-179 # PDB 4V6S EM; 13.10 A; AG=2-179 # PDB 4V6T EM; 8.30 A; BF=2-178 # PDB 4V6V EM; 9.80 A; BG=2-179 # PDB 4V6Y EM; 12.00 A; BF=1-179 # PDB 4V6Z EM; 12.00 A; BF=1-179 # PDB 4V70 EM; 17.00 A; BF=1-179 # PDB 4V71 EM; 20.00 A; BF=1-179 # PDB 4V72 EM; 13.00 A; BF=1-179 # PDB 4V73 EM; 15.00 A; BF=1-179 # PDB 4V74 EM; 17.00 A; BF=1-179 # PDB 4V75 EM; 12.00 A; BF=1-179 # PDB 4V76 EM; 17.00 A; BF=1-179 # PDB 4V77 EM; 17.00 A; BF=1-179 # PDB 4V78 EM; 20.00 A; BF=1-179 # PDB 4V79 EM; 15.00 A; BF=1-179 # PDB 4V7A EM; 9.00 A; BF=1-179 # PDB 4V7B EM; 6.80 A; BF=1-179 # PDB 4V7C EM; 7.60 A; BG=2-179 # PDB 4V7D EM; 7.60 A; AG=2-179 # PDB 4V7I EM; 9.60 A; AF=1-179 # PDB 4V7S X-ray; 3.25 A; BF=2-178, DF=2-179 # PDB 4V7T X-ray; 3.19 A; BF=2-178, DF=2-179 # PDB 4V7U X-ray; 3.10 A; BF/DF=2-179 # PDB 4V7V X-ray; 3.29 A; BF=2-178, DF=2-179 # PDB 4V85 X-ray; 3.20 A; F=1-179 # PDB 4V89 X-ray; 3.70 A; BF=1-179 # PDB 4V9C X-ray; 3.30 A; BF/DF=1-179 # PDB 4V9D X-ray; 3.00 A; CF/DF=2-178 # PDB 4V9O X-ray; 2.90 A; AF/CF/EF/GF=1-179 # PDB 4V9P X-ray; 2.90 A; AF/CF/EF/GF=1-179 # PDB 4WF1 X-ray; 3.09 A; BF/DF=2-178 # PDB 4WOI X-ray; 3.00 A; BF/CF=1-179 # PDB 4WWW X-ray; 3.10 A; RF/YF=2-179 # PDB 4YBB X-ray; 2.10 A; CF/DF=2-178 # PDB 5ADY EM; 4.50 A; F=1-179 # PDB 5AFI EM; 2.90 A; F=1-179 # PDB 5AKA EM; 5.70 A; F=2-179 # PDB 5GAD EM; 3.70 A; F=1-179 # PDB 5GAE EM; 3.33 A; F=1-179 # PDB 5GAF EM; 4.30 A; F=2-178 # PDB 5GAG EM; 3.80 A; F=1-179 # PDB 5GAH EM; 3.80 A; F=1-179 # PDB 5IQR EM; 3.00 A; E=1-179 # PDB 5IT8 X-ray; 3.12 A; CF/DF=2-178 # PDB 5J5B X-ray; 2.80 A; CF/DF=2-178 # PDB 5J7L X-ray; 3.00 A; CF/DF=2-178 # PDB 5J88 X-ray; 3.32 A; CF/DF=2-179 # PDB 5J8A X-ray; 3.10 A; CF/DF=2-179 # PDB 5J91 X-ray; 2.96 A; CF/DF=2-179 # PDB 5JC9 X-ray; 3.03 A; CF/DF=2-178 # PDB 5JTE EM; 3.60 A; BF=1-179 # PDB 5JU8 EM; 3.60 A; BF=1-179 # PDB 5KCR EM; 3.60 A; 1G=1-179 # PDB 5KCS EM; 3.90 A; 1G=1-179 # PDB 5KPS EM; 3.90 A; E=1-179 # PDB 5KPV EM; 4.10 A; D=1-179 # PDB 5KPW EM; 3.90 A; D=1-179 # PDB 5KPX EM; 3.90 A; D=1-179 # PDB 5L3P EM; 3.70 A; G=1-179 # PIR G65123 R5EC5 # PIRSF PIRSF002161 Ribosomal_L5 # PROSITE PS00358 RIBOSOMAL_L5 # Pfam PF00281 Ribosomal_L5 # Pfam PF00673 Ribosomal_L5_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RL5_ECOLI 50S ribosomal protein L5 # RefSeq NP_417767 NC_000913.3 # RefSeq WP_001096200 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein L5P family. {ECO 0000305}. # SUBUNIT RL5_ECOLI Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA; cross-links to the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome, contacting protein S13 and S19. {ECO 0000269|PubMed 12809609, ECO 0000269|PubMed 12859903, ECO 0000269|PubMed 16272117, ECO 0000269|PubMed 354687, ECO 0000269|PubMed 7038683, ECO 0000269|PubMed 8524654, ECO 0000269|PubMed 8925931}. # SUPFAM SSF55282 SSF55282 # eggNOG COG0094 LUCA # eggNOG ENOG4105CW6 Bacteria BLAST swissprot:RL5_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RL5_ECOLI BioCyc ECOL316407:JW3270-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3270-MONOMER BioCyc EcoCyc:EG10868-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10868-MONOMER BioCyc MetaCyc:EG10868-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10868-MONOMER COG COG0094 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0094 DIP DIP-35914N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35914N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1016/0014-5793(76)80695-3 http://dx.doi.org/10.1016/0014-5793(76)80695-3 DOI 10.1016/0014-5793(96)00872-1 http://dx.doi.org/10.1016/0014-5793(96)00872-1 DOI 10.1016/S0092-8674(03)00427-6 http://dx.doi.org/10.1016/S0092-8674(03)00427-6 DOI 10.1016/S0092-8674(03)00476-8 http://dx.doi.org/10.1016/S0092-8674(03)00476-8 DOI 10.1016/j.celrep.2014.09.011 http://dx.doi.org/10.1016/j.celrep.2014.09.011 DOI 10.1021/bi00606a002 http://dx.doi.org/10.1021/bi00606a002 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.79.3.729 http://dx.doi.org/10.1073/pnas.79.3.729 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/nar/11.9.2599 http://dx.doi.org/10.1093/nar/11.9.2599 DOI 10.1093/nar/23.22.4635 http://dx.doi.org/10.1093/nar/23.22.4635 DOI 10.1093/nar/9.7.1757 http://dx.doi.org/10.1093/nar/9.7.1757 DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pbio.1001866 http://dx.doi.org/10.1371/journal.pbio.1001866 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M10195 http://www.ebi.ac.uk/ena/data/view/M10195 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X01563 http://www.ebi.ac.uk/ena/data/view/X01563 EchoBASE EB0861 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0861 EcoGene EG10868 http://www.ecogene.org/geneInfo.php?eg_id=EG10868 EnsemblBacteria AAC76333 http://www.ensemblgenomes.org/id/AAC76333 EnsemblBacteria AAC76333 http://www.ensemblgenomes.org/id/AAC76333 EnsemblBacteria BAE77983 http://www.ensemblgenomes.org/id/BAE77983 EnsemblBacteria BAE77983 http://www.ensemblgenomes.org/id/BAE77983 EnsemblBacteria BAE77983 http://www.ensemblgenomes.org/id/BAE77983 EnsemblBacteria b3308 http://www.ensemblgenomes.org/id/b3308 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0022625 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022625 GO_function GO:0000049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000049 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_function GO:0008097 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008097 GO_process GO:0000027 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000027 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_process GO:0022618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022618 Gene3D 3.30.1440.10 http://www.cathdb.info/version/latest/superfamily/3.30.1440.10 GeneID 24910142 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24910142 GeneID 947800 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947800 HAMAP MF_01333_B http://hamap.expasy.org/unirule/MF_01333_B HOGENOM HOG000231311 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231311&db=HOGENOM6 InParanoid P62399 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P62399 IntAct P62399 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P62399* InterPro IPR002132 http://www.ebi.ac.uk/interpro/entry/IPR002132 InterPro IPR020929 http://www.ebi.ac.uk/interpro/entry/IPR020929 InterPro IPR020930 http://www.ebi.ac.uk/interpro/entry/IPR020930 InterPro IPR022803 http://www.ebi.ac.uk/interpro/entry/IPR022803 InterPro IPR031309 http://www.ebi.ac.uk/interpro/entry/IPR031309 InterPro IPR031310 http://www.ebi.ac.uk/interpro/entry/IPR031310 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW3270 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3270 KEGG_Gene eco:b3308 http://www.genome.jp/dbget-bin/www_bget?eco:b3308 KEGG_Orthology KO:K02931 http://www.genome.jp/dbget-bin/www_bget?KO:K02931 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 MINT MINT-1238892 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1238892 OMA EQVMFHE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EQVMFHE PDB 1ML5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ML5 PDB 2J28 http://www.ebi.ac.uk/pdbe-srv/view/entry/2J28 PDB 2RDO http://www.ebi.ac.uk/pdbe-srv/view/entry/2RDO PDB 3BBX http://www.ebi.ac.uk/pdbe-srv/view/entry/3BBX PDB 3J5L http://www.ebi.ac.uk/pdbe-srv/view/entry/3J5L PDB 3J5S http://www.ebi.ac.uk/pdbe-srv/view/entry/3J5S PDB 3J7Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J7Z PDB 3J8G http://www.ebi.ac.uk/pdbe-srv/view/entry/3J8G PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 4CSU http://www.ebi.ac.uk/pdbe-srv/view/entry/4CSU PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4UY8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4UY8 PDB 4V47 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V47 PDB 4V48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V48 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5ADY http://www.ebi.ac.uk/pdbe-srv/view/entry/5ADY PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5AKA http://www.ebi.ac.uk/pdbe-srv/view/entry/5AKA PDB 5GAD http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAD PDB 5GAE http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAE PDB 5GAF http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAF PDB 5GAG http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAG PDB 5GAH http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAH PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 1ML5 http://www.ebi.ac.uk/pdbsum/1ML5 PDBsum 2J28 http://www.ebi.ac.uk/pdbsum/2J28 PDBsum 2RDO http://www.ebi.ac.uk/pdbsum/2RDO PDBsum 3BBX http://www.ebi.ac.uk/pdbsum/3BBX PDBsum 3J5L http://www.ebi.ac.uk/pdbsum/3J5L PDBsum 3J5S http://www.ebi.ac.uk/pdbsum/3J5S PDBsum 3J7Z http://www.ebi.ac.uk/pdbsum/3J7Z PDBsum 3J8G http://www.ebi.ac.uk/pdbsum/3J8G PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 4CSU http://www.ebi.ac.uk/pdbsum/4CSU PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4UY8 http://www.ebi.ac.uk/pdbsum/4UY8 PDBsum 4V47 http://www.ebi.ac.uk/pdbsum/4V47 PDBsum 4V48 http://www.ebi.ac.uk/pdbsum/4V48 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5ADY http://www.ebi.ac.uk/pdbsum/5ADY PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5AKA http://www.ebi.ac.uk/pdbsum/5AKA PDBsum 5GAD http://www.ebi.ac.uk/pdbsum/5GAD PDBsum 5GAE http://www.ebi.ac.uk/pdbsum/5GAE PDBsum 5GAF http://www.ebi.ac.uk/pdbsum/5GAF PDBsum 5GAG http://www.ebi.ac.uk/pdbsum/5GAG PDBsum 5GAH http://www.ebi.ac.uk/pdbsum/5GAH PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PROSITE PS00358 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00358 PSORT swissprot:RL5_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RL5_ECOLI PSORT-B swissprot:RL5_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RL5_ECOLI PSORT2 swissprot:RL5_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RL5_ECOLI Pfam PF00281 http://pfam.xfam.org/family/PF00281 Pfam PF00673 http://pfam.xfam.org/family/PF00673 Phobius swissprot:RL5_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RL5_ECOLI PhylomeDB P62399 http://phylomedb.org/?seqid=P62399 ProteinModelPortal P62399 http://www.proteinmodelportal.org/query/uniprot/P62399 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 12809609 http://www.ncbi.nlm.nih.gov/pubmed/12809609 PubMed 12859903 http://www.ncbi.nlm.nih.gov/pubmed/12859903 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 24844575 http://www.ncbi.nlm.nih.gov/pubmed/24844575 PubMed 25310980 http://www.ncbi.nlm.nih.gov/pubmed/25310980 PubMed 354687 http://www.ncbi.nlm.nih.gov/pubmed/354687 PubMed 6222285 http://www.ncbi.nlm.nih.gov/pubmed/6222285 PubMed 6262737 http://www.ncbi.nlm.nih.gov/pubmed/6262737 PubMed 7038683 http://www.ncbi.nlm.nih.gov/pubmed/7038683 PubMed 791672 http://www.ncbi.nlm.nih.gov/pubmed/791672 PubMed 8524654 http://www.ncbi.nlm.nih.gov/pubmed/8524654 PubMed 8925931 http://www.ncbi.nlm.nih.gov/pubmed/8925931 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417767 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417767 RefSeq WP_001096200 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001096200 SMR P62399 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P62399 STRING 511145.b3308 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3308&targetmode=cogs STRING COG0094 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0094&targetmode=cogs SUPFAM SSF55282 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55282 UniProtKB RL5_ECOLI http://www.uniprot.org/uniprot/RL5_ECOLI UniProtKB-AC P62399 http://www.uniprot.org/uniprot/P62399 charge swissprot:RL5_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RL5_ECOLI eggNOG COG0094 http://eggnogapi.embl.de/nog_data/html/tree/COG0094 eggNOG ENOG4105CW6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CW6 epestfind swissprot:RL5_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RL5_ECOLI garnier swissprot:RL5_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RL5_ECOLI helixturnhelix swissprot:RL5_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RL5_ECOLI hmoment swissprot:RL5_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RL5_ECOLI iep swissprot:RL5_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RL5_ECOLI inforesidue swissprot:RL5_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RL5_ECOLI octanol swissprot:RL5_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RL5_ECOLI pepcoil swissprot:RL5_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RL5_ECOLI pepdigest swissprot:RL5_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RL5_ECOLI pepinfo swissprot:RL5_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RL5_ECOLI pepnet swissprot:RL5_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RL5_ECOLI pepstats swissprot:RL5_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RL5_ECOLI pepwheel swissprot:RL5_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RL5_ECOLI pepwindow swissprot:RL5_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RL5_ECOLI sigcleave swissprot:RL5_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RL5_ECOLI ## Database ID URL or Descriptions # BioGrid 4259887 12 # EcoGene EG13639 ybcW # IntAct P64435 3 # MISCELLANEOUS YBCW_ECOLI Encoded by the cryptic lambdoid prophage DLP12. # Organism YBCW_ECOLI Escherichia coli (strain K12) # PATRIC 32116284 VBIEscCol129921_0582 # PIR E64788 E64788 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBCW_ECOLI Uncharacterized protein YbcW # RefSeq NP_415091 NC_000913.3 # RefSeq WP_001031427 NZ_LN832404.1 BLAST swissprot:YBCW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBCW_ECOLI BioCyc ECOL316407:JW0548-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0548-MONOMER BioCyc EcoCyc:G6314-MONOMER http://biocyc.org/getid?id=EcoCyc:G6314-MONOMER DIP DIP-11340N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11340N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3403 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3403 EcoGene EG13639 http://www.ecogene.org/geneInfo.php?eg_id=EG13639 EnsemblBacteria AAC73660 http://www.ensemblgenomes.org/id/AAC73660 EnsemblBacteria AAC73660 http://www.ensemblgenomes.org/id/AAC73660 EnsemblBacteria BAE76335 http://www.ensemblgenomes.org/id/BAE76335 EnsemblBacteria BAE76335 http://www.ensemblgenomes.org/id/BAE76335 EnsemblBacteria BAE76335 http://www.ensemblgenomes.org/id/BAE76335 EnsemblBacteria b0559 http://www.ensemblgenomes.org/id/b0559 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945175 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945175 HOGENOM HOG000054898 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000054898&db=HOGENOM6 IntAct P64435 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P64435* KEGG_Gene ecj:JW0548 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0548 KEGG_Gene eco:b0559 http://www.genome.jp/dbget-bin/www_bget?eco:b0559 OMA VIIACIE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VIIACIE PSORT swissprot:YBCW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBCW_ECOLI PSORT-B swissprot:YBCW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBCW_ECOLI PSORT2 swissprot:YBCW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBCW_ECOLI Phobius swissprot:YBCW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBCW_ECOLI ProteinModelPortal P64435 http://www.proteinmodelportal.org/query/uniprot/P64435 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415091 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415091 RefSeq WP_001031427 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001031427 STRING 511145.b0559 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0559&targetmode=cogs UniProtKB YBCW_ECOLI http://www.uniprot.org/uniprot/YBCW_ECOLI UniProtKB-AC P64435 http://www.uniprot.org/uniprot/P64435 charge swissprot:YBCW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBCW_ECOLI epestfind swissprot:YBCW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBCW_ECOLI garnier swissprot:YBCW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBCW_ECOLI helixturnhelix swissprot:YBCW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBCW_ECOLI hmoment swissprot:YBCW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBCW_ECOLI iep swissprot:YBCW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBCW_ECOLI inforesidue swissprot:YBCW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBCW_ECOLI octanol swissprot:YBCW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBCW_ECOLI pepcoil swissprot:YBCW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBCW_ECOLI pepdigest swissprot:YBCW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBCW_ECOLI pepinfo swissprot:YBCW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBCW_ECOLI pepnet swissprot:YBCW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBCW_ECOLI pepstats swissprot:YBCW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBCW_ECOLI pepwheel swissprot:YBCW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBCW_ECOLI pepwindow swissprot:YBCW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBCW_ECOLI sigcleave swissprot:YBCW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBCW_ECOLI ## Database ID URL or Descriptions # AltName NAGB_ECOLI GlcN6P deaminase # AltName NAGB_ECOLI Glucosamine-6-phosphate isomerase # BRENDA 3.5.99 2026 # BioGrid 4261792 7 # CATALYTIC ACTIVITY NAGB_ECOLI Alpha-D-glucosamine 6-phosphate + H(2)O = D- fructose 6-phosphate + NH(3). # CDD cd01399 GlcN6P_deaminase # ENZYME REGULATION NAGB_ECOLI Allosterically activated by N-acetylglucosamine 6-phosphate (GlcNAc6P). Competitively inhibited by 2-amino-2- deoxy-D-glucitol-6-phosphate (GlcN-ol-6P). # EcoGene EG10633 nagB # FUNCTION NAGB_ECOLI Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004342 glucosamine-6-phosphate deaminase activity; IDA:EcoCyc. # GO_function GO:0016787 hydrolase activity; IEA:UniProtKB-KW. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0005975 carbohydrate metabolic process; IEA:UniProtKB-KW. # GO_process GO:0006046 N-acetylglucosamine catabolic process; IMP:EcoCyc. # GO_process GO:0006048 UDP-N-acetylglucosamine biosynthetic process; IGI:EcoCyc. # GO_process GO:0019262 N-acetylneuraminate catabolic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # HAMAP MF_01241 GlcN6P_deamin # IntAct P0A759 11 # InterPro IPR004547 Glucosamine6P_isomerase # InterPro IPR006148 Glc/Gal-6P_isomerase # InterPro IPR018321 Glucosamine6P_isomerase_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00520 Amino sugar and nucleotide sugar metabolism # MISCELLANEOUS NAGB_ECOLI Disulfide bonds seem not to be essential for the stability of the oligomer under physiological conditions. # Organism NAGB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11280 PTHR11280 # PATHWAY Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate step 5/5. # PATRIC 32116541 VBIEscCol129921_0703 # PDB 1CD5 X-ray; 2.30 A; A=1-266 # PDB 1DEA X-ray; 2.10 A; A/B=1-266 # PDB 1FQO X-ray; 2.20 A; A/B=1-266 # PDB 1FRZ X-ray; 2.20 A; A/B=1-266 # PDB 1FS5 X-ray; 1.73 A; A/B=1-266 # PDB 1FS6 X-ray; 2.20 A; A=1-266 # PDB 1FSF X-ray; 1.90 A; A=1-266 # PDB 1HOR X-ray; 2.40 A; A/B=1-266 # PDB 1HOT X-ray; 2.40 A; A/B=1-266 # PDB 1JT9 X-ray; 2.06 A; A=1-266 # PDB 2WU1 X-ray; 2.20 A; A/B=1-266 # PIR A29895 MUECNG # PROSITE PS01161 GLC_GALNAC_ISOMERASE # Pfam PF01182 Glucosamine_iso # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NAGB_ECOLI Glucosamine-6-phosphate deaminase # RefSeq NP_415204 NC_000913.3 # RefSeq WP_001237072 NZ_LN832404.1 # SIMILARITY Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily. {ECO 0000305}. # SUBUNIT Homohexamer; trimer of disulfide-linked dimers. {ECO:0000269|PubMed 8240271}. # TIGRFAMs TIGR00502 nagB # UniPathway UPA00629 UER00684 # eggNOG COG0363 LUCA # eggNOG ENOG4105CKA Bacteria BLAST swissprot:NAGB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NAGB_ECOLI BioCyc ECOL316407:JW0664-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0664-MONOMER BioCyc EcoCyc:GLUCOSAMINE-6-P-DEAMIN-MONOMER http://biocyc.org/getid?id=EcoCyc:GLUCOSAMINE-6-P-DEAMIN-MONOMER BioCyc MetaCyc:GLUCOSAMINE-6-P-DEAMIN-MONOMER http://biocyc.org/getid?id=MetaCyc:GLUCOSAMINE-6-P-DEAMIN-MONOMER COG COG0363 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0363 DIP DIP-35992N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35992N DOI 10.1016/0378-1119(88)90558-6 http://dx.doi.org/10.1016/0378-1119(88)90558-6 DOI 10.1016/S0022-2836(02)00096-7 http://dx.doi.org/10.1016/S0022-2836(02)00096-7 DOI 10.1016/S0969-2126(01)00270-2 http://dx.doi.org/10.1016/S0969-2126(01)00270-2 DOI 10.1016/S0969-2126(99)80069-0 http://dx.doi.org/10.1016/S0969-2126(99)80069-0 DOI 10.1021/bi00119a026 http://dx.doi.org/10.1021/bi00119a026 DOI 10.1021/bi0105835 http://dx.doi.org/10.1021/bi0105835 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2950645 http://dx.doi.org/10.1042/bj2950645 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.5.99.6 http://www.genome.jp/dbget-bin/www_bget?EC:3.5.99.6 EMBL AF052007 http://www.ebi.ac.uk/ena/data/view/AF052007 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M19284 http://www.ebi.ac.uk/ena/data/view/M19284 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.5.99.6 http://enzyme.expasy.org/EC/3.5.99.6 EchoBASE EB0627 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0627 EcoGene EG10633 http://www.ecogene.org/geneInfo.php?eg_id=EG10633 EnsemblBacteria AAC73772 http://www.ensemblgenomes.org/id/AAC73772 EnsemblBacteria AAC73772 http://www.ensemblgenomes.org/id/AAC73772 EnsemblBacteria BAA35321 http://www.ensemblgenomes.org/id/BAA35321 EnsemblBacteria BAA35321 http://www.ensemblgenomes.org/id/BAA35321 EnsemblBacteria BAA35321 http://www.ensemblgenomes.org/id/BAA35321 EnsemblBacteria b0678 http://www.ensemblgenomes.org/id/b0678 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004342 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004342 GO_function GO:0016787 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016787 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GO_process GO:0006046 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006046 GO_process GO:0006048 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006048 GO_process GO:0019262 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019262 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 945290 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945290 HAMAP MF_01241 http://hamap.expasy.org/unirule/MF_01241 HOGENOM HOG000064979 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000064979&db=HOGENOM6 InParanoid P0A759 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A759 IntAct P0A759 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A759* IntEnz 3.5.99.6 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.99.6 InterPro IPR004547 http://www.ebi.ac.uk/interpro/entry/IPR004547 InterPro IPR006148 http://www.ebi.ac.uk/interpro/entry/IPR006148 InterPro IPR018321 http://www.ebi.ac.uk/interpro/entry/IPR018321 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0664 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0664 KEGG_Gene eco:b0678 http://www.genome.jp/dbget-bin/www_bget?eco:b0678 KEGG_Orthology KO:K02564 http://www.genome.jp/dbget-bin/www_bget?KO:K02564 KEGG_Pathway ko00520 http://www.genome.jp/kegg-bin/show_pathway?ko00520 KEGG_Reaction rn:R00765 http://www.genome.jp/dbget-bin/www_bget?rn:R00765 OMA SALQMHR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SALQMHR PANTHER PTHR11280 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11280 PDB 1CD5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1CD5 PDB 1DEA http://www.ebi.ac.uk/pdbe-srv/view/entry/1DEA PDB 1FQO http://www.ebi.ac.uk/pdbe-srv/view/entry/1FQO PDB 1FRZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1FRZ PDB 1FS5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1FS5 PDB 1FS6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1FS6 PDB 1FSF http://www.ebi.ac.uk/pdbe-srv/view/entry/1FSF PDB 1HOR http://www.ebi.ac.uk/pdbe-srv/view/entry/1HOR PDB 1HOT http://www.ebi.ac.uk/pdbe-srv/view/entry/1HOT PDB 1JT9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1JT9 PDB 2WU1 http://www.ebi.ac.uk/pdbe-srv/view/entry/2WU1 PDBsum 1CD5 http://www.ebi.ac.uk/pdbsum/1CD5 PDBsum 1DEA http://www.ebi.ac.uk/pdbsum/1DEA PDBsum 1FQO http://www.ebi.ac.uk/pdbsum/1FQO PDBsum 1FRZ http://www.ebi.ac.uk/pdbsum/1FRZ PDBsum 1FS5 http://www.ebi.ac.uk/pdbsum/1FS5 PDBsum 1FS6 http://www.ebi.ac.uk/pdbsum/1FS6 PDBsum 1FSF http://www.ebi.ac.uk/pdbsum/1FSF PDBsum 1HOR http://www.ebi.ac.uk/pdbsum/1HOR PDBsum 1HOT http://www.ebi.ac.uk/pdbsum/1HOT PDBsum 1JT9 http://www.ebi.ac.uk/pdbsum/1JT9 PDBsum 2WU1 http://www.ebi.ac.uk/pdbsum/2WU1 PROSITE PS01161 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01161 PSORT swissprot:NAGB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NAGB_ECOLI PSORT-B swissprot:NAGB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NAGB_ECOLI PSORT2 swissprot:NAGB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NAGB_ECOLI Pfam PF01182 http://pfam.xfam.org/family/PF01182 Phobius swissprot:NAGB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NAGB_ECOLI PhylomeDB P0A759 http://phylomedb.org/?seqid=P0A759 ProteinModelPortal P0A759 http://www.proteinmodelportal.org/query/uniprot/P0A759 PubMed 10378272 http://www.ncbi.nlm.nih.gov/pubmed/10378272 PubMed 11513596 http://www.ncbi.nlm.nih.gov/pubmed/11513596 PubMed 11752775 http://www.ncbi.nlm.nih.gov/pubmed/11752775 PubMed 12051945 http://www.ncbi.nlm.nih.gov/pubmed/12051945 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1734962 http://www.ncbi.nlm.nih.gov/pubmed/1734962 PubMed 2190615 http://www.ncbi.nlm.nih.gov/pubmed/2190615 PubMed 3284790 http://www.ncbi.nlm.nih.gov/pubmed/3284790 PubMed 8240271 http://www.ncbi.nlm.nih.gov/pubmed/8240271 PubMed 8747459 http://www.ncbi.nlm.nih.gov/pubmed/8747459 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415204 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415204 RefSeq WP_001237072 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001237072 SMR P0A759 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A759 STRING 511145.b0678 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0678&targetmode=cogs STRING COG0363 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0363&targetmode=cogs TIGRFAMs TIGR00502 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00502 UniProtKB NAGB_ECOLI http://www.uniprot.org/uniprot/NAGB_ECOLI UniProtKB-AC P0A759 http://www.uniprot.org/uniprot/P0A759 charge swissprot:NAGB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NAGB_ECOLI eggNOG COG0363 http://eggnogapi.embl.de/nog_data/html/tree/COG0363 eggNOG ENOG4105CKA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CKA epestfind swissprot:NAGB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NAGB_ECOLI garnier swissprot:NAGB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NAGB_ECOLI helixturnhelix swissprot:NAGB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NAGB_ECOLI hmoment swissprot:NAGB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NAGB_ECOLI iep swissprot:NAGB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NAGB_ECOLI inforesidue swissprot:NAGB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NAGB_ECOLI octanol swissprot:NAGB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NAGB_ECOLI pepcoil swissprot:NAGB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NAGB_ECOLI pepdigest swissprot:NAGB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NAGB_ECOLI pepinfo swissprot:NAGB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NAGB_ECOLI pepnet swissprot:NAGB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NAGB_ECOLI pepstats swissprot:NAGB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NAGB_ECOLI pepwheel swissprot:NAGB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NAGB_ECOLI pepwindow swissprot:NAGB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NAGB_ECOLI sigcleave swissprot:NAGB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NAGB_ECOLI ## Database ID URL or Descriptions # AltName GNTP_ECOLI Gluconate permease 3 # AltName GNTP_ECOLI Gnt-III system # BioGrid 4261000 6 # EcoGene EG12563 gntP # FUNCTION GNTP_ECOLI High-affinity gluconate transporter with fairly broad specificity, including low affinity for glucuronate, several disaccharides, and some hexoses, but not glucose. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoliWiki. # GO_component GO:0016020 membrane; IDA:EcoCyc. # GO_function GNTP_ECOLI GO 0005351 sugar proton symporter activity; IMP EcoCyc. # GO_function GO:0015128 gluconate transmembrane transporter activity; IDA:EcoCyc. # GO_process GO:0035429 gluconate transmembrane transport; IDA:EcoCyc. # GO_process GO:0046177 D-gluconate catabolic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0055085 transmembrane transport # InterPro IPR003474 Glcn_transporter # KEGG_Brite ko02000 Transporters # Organism GNTP_ECOLI Escherichia coli (strain K12) # PATHWAY GNTP_ECOLI Carbohydrate acid metabolism; D-gluconate degradation. # PATRIC 32124238 VBIEscCol129921_4462 # PIR S56546 S56546 # PIRSF PIRSF002746 Gluconate_transporter # Pfam PF02447 GntP_permease # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GNTP_ECOLI High-affinity gluconate transporter # RefSeq NP_418741 NC_000913.3 # RefSeq WP_000558251 NZ_LN832404.1 # SIMILARITY Belongs to the GntP permease family. {ECO 0000305}. # SUBCELLULAR LOCATION GNTP_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.8.1:the gluconate h(+) symporter (gntp) family # TIGRFAMs TIGR00791 gntP # eggNOG COG2610 LUCA # eggNOG ENOG4107EFN Bacteria BLAST swissprot:GNTP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GNTP_ECOLI BioCyc ECOL316407:JW4284-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4284-MONOMER BioCyc EcoCyc:GNTP-MONOMER http://biocyc.org/getid?id=EcoCyc:GNTP-MONOMER BioCyc MetaCyc:GNTP-MONOMER http://biocyc.org/getid?id=MetaCyc:GNTP-MONOMER COG COG2610 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2610 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X91735 http://www.ebi.ac.uk/ena/data/view/X91735 EchoBASE EB2451 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2451 EcoGene EG12563 http://www.ecogene.org/geneInfo.php?eg_id=EG12563 EnsemblBacteria AAC77277 http://www.ensemblgenomes.org/id/AAC77277 EnsemblBacteria AAC77277 http://www.ensemblgenomes.org/id/AAC77277 EnsemblBacteria BAE78314 http://www.ensemblgenomes.org/id/BAE78314 EnsemblBacteria BAE78314 http://www.ensemblgenomes.org/id/BAE78314 EnsemblBacteria BAE78314 http://www.ensemblgenomes.org/id/BAE78314 EnsemblBacteria b4321 http://www.ensemblgenomes.org/id/b4321 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0005351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005351 GO_function GO:0015128 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015128 GO_process GO:0035429 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035429 GO_process GO:0046177 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046177 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 948848 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948848 HOGENOM HOG000237115 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000237115&db=HOGENOM6 InParanoid P0AC94 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AC94 InterPro IPR003474 http://www.ebi.ac.uk/interpro/entry/IPR003474 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW4284 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4284 KEGG_Gene eco:b4321 http://www.genome.jp/dbget-bin/www_bget?eco:b4321 KEGG_Orthology KO:K16321 http://www.genome.jp/dbget-bin/www_bget?KO:K16321 OMA AIDENDR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AIDENDR PSORT swissprot:GNTP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GNTP_ECOLI PSORT-B swissprot:GNTP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GNTP_ECOLI PSORT2 swissprot:GNTP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GNTP_ECOLI Pfam PF02447 http://pfam.xfam.org/family/PF02447 Phobius swissprot:GNTP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GNTP_ECOLI PhylomeDB P0AC94 http://phylomedb.org/?seqid=P0AC94 ProteinModelPortal P0AC94 http://www.proteinmodelportal.org/query/uniprot/P0AC94 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8550444 http://www.ncbi.nlm.nih.gov/pubmed/8550444 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418741 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418741 RefSeq WP_000558251 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000558251 STRING 511145.b4321 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4321&targetmode=cogs STRING COG2610 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2610&targetmode=cogs TCDB 2.A.8.1 http://www.tcdb.org/search/result.php?tc=2.A.8.1 TIGRFAMs TIGR00791 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00791 UniProtKB GNTP_ECOLI http://www.uniprot.org/uniprot/GNTP_ECOLI UniProtKB-AC P0AC94 http://www.uniprot.org/uniprot/P0AC94 charge swissprot:GNTP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GNTP_ECOLI eggNOG COG2610 http://eggnogapi.embl.de/nog_data/html/tree/COG2610 eggNOG ENOG4107EFN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107EFN epestfind swissprot:GNTP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GNTP_ECOLI garnier swissprot:GNTP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GNTP_ECOLI helixturnhelix swissprot:GNTP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GNTP_ECOLI hmoment swissprot:GNTP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GNTP_ECOLI iep swissprot:GNTP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GNTP_ECOLI inforesidue swissprot:GNTP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GNTP_ECOLI octanol swissprot:GNTP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GNTP_ECOLI pepcoil swissprot:GNTP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GNTP_ECOLI pepdigest swissprot:GNTP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GNTP_ECOLI pepinfo swissprot:GNTP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GNTP_ECOLI pepnet swissprot:GNTP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GNTP_ECOLI pepstats swissprot:GNTP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GNTP_ECOLI pepwheel swissprot:GNTP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GNTP_ECOLI pepwindow swissprot:GNTP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GNTP_ECOLI sigcleave swissprot:GNTP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GNTP_ECOLI ## Database ID URL or Descriptions # EcoGene EG10869 rplF # FUNCTION RL6_ECOLI Gentamicin-resistant mutations in this protein affect translation fidelity. {ECO 0000269|PubMed 369594}. # FUNCTION RL6_ECOLI This protein binds directly to at least 2 domains of the 23S ribosomal RNA, thus is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. {ECO 0000269|PubMed 6170935}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0022625 cytosolic large ribosomal subunit; IDA:EcoCyc. # GO_function GO:0003723 RNA binding; IBA:GO_Central. # GO_function GO:0003735 structural constituent of ribosome; IBA:GO_Central. # GO_function GO:0019843 rRNA binding; IEA:UniProtKB-HAMAP. # GO_process GO:0002181 cytoplasmic translation; IBA:GO_Central. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_function GO:0019843 rRNA binding # GOslim_process GO:0006412 translation # GOslim_process GO:0008150 biological_process # Gene3D 3.90.930.12 -; 2. # HAMAP MF_01365_B Ribosomal_L6_B # IntAct P0AG55 83 # InterPro IPR000702 Ribosomal_L6 # InterPro IPR002358 Ribosomal_L6_CS # InterPro IPR019906 Ribosomal_L6_bac-type # InterPro IPR020040 Ribosomal_L6_a/b-dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 M00179 Ribosome, archaea # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=18772.7; Method=MALDI; Range=2-177; Evidence={ECO:0000269|PubMed 10094780}; # Organism RL6_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11655 PTHR11655 # PATRIC 32122042 VBIEscCol129921_3398 # PDB 1EG0 EM; 11.50 A; J=1-171 # PDB 1ML5 EM; 14.00 A; h=2-177 # PDB 2J28 EM; 8.00 A; G=2-177 # PDB 2RDO EM; 9.10 A; G=2-177 # PDB 3BBX EM; 10.00 A; G=2-177 # PDB 3J5L EM; 6.60 A; G=2-177 # PDB 3J7Z EM; 3.90 A; G=1-177 # PDB 3J8G EM; 5.00 A; G=1-177 # PDB 3J9Y EM; 3.90 A; G=1-177 # PDB 3J9Z EM; 3.60 A; L8=2-177 # PDB 3JA1 EM; 3.60 A; LH=2-177 # PDB 3JBU EM; 3.64 A; g=1-177 # PDB 3JBV EM; 3.32 A; g=1-177 # PDB 3JCD EM; 3.70 A; G=1-177 # PDB 3JCE EM; 3.20 A; G=1-177 # PDB 3JCJ EM; 3.70 A; F=1-177 # PDB 3JCN EM; 4.60 A; G=1-177 # PDB 487D EM; 7.50 A; J=31-165 # PDB 4CSU EM; 5.50 A; G=2-177 # PDB 4U1U X-ray; 2.95 A; BG/DG=2-177 # PDB 4U1V X-ray; 3.00 A; BG/DG=2-177 # PDB 4U20 X-ray; 2.90 A; BG/DG=2-177 # PDB 4U24 X-ray; 2.90 A; BG/DG=2-177 # PDB 4U25 X-ray; 2.90 A; BG/DG=2-177 # PDB 4U26 X-ray; 2.80 A; BG/DG=2-177 # PDB 4U27 X-ray; 2.80 A; BG/DG=2-177 # PDB 4UY8 EM; 3.80 A; G=2-177 # PDB 4V47 EM; 12.30 A; AE=2-177 # PDB 4V48 EM; 11.50 A; AE=2-177 # PDB 4V4H X-ray; 3.46 A; BG/DG=1-177 # PDB 4V4Q X-ray; 3.46 A; BG/DG=2-177 # PDB 4V4V EM; 15.00 A; BE=6-172 # PDB 4V4W EM; 15.00 A; BE=6-172 # PDB 4V50 X-ray; 3.22 A; BG/DG=2-177 # PDB 4V52 X-ray; 3.21 A; BG/DG=2-177 # PDB 4V53 X-ray; 3.54 A; BG/DG=2-177 # PDB 4V54 X-ray; 3.30 A; BG/DG=2-177 # PDB 4V55 X-ray; 4.00 A; BG/DG=2-177 # PDB 4V56 X-ray; 3.93 A; BG/DG=2-177 # PDB 4V57 X-ray; 3.50 A; BG/DG=2-177 # PDB 4V5B X-ray; 3.74 A; AG/CG=2-177 # PDB 4V5H EM; 5.80 A; BG=2-177 # PDB 4V5Y X-ray; 4.45 A; BG/DG=2-177 # PDB 4V64 X-ray; 3.50 A; BG/DG=2-177 # PDB 4V65 EM; 9.00 A; B3=1-177 # PDB 4V66 EM; 9.00 A; B3=1-177 # PDB 4V69 EM; 6.70 A; BG=2-177 # PDB 4V6C X-ray; 3.19 A; BG/DG=1-177 # PDB 4V6D X-ray; 3.81 A; BG/DG=1-177 # PDB 4V6E X-ray; 3.71 A; BG/DG=1-177 # PDB 4V6K EM; 8.25 A; AH=1-177 # PDB 4V6L EM; 13.20 A; BH=1-177 # PDB 4V6M EM; 7.10 A; BG=2-177 # PDB 4V6N EM; 12.10 A; AH=2-177 # PDB 4V6O EM; 14.70 A; BH=2-177 # PDB 4V6P EM; 13.50 A; BH=2-177 # PDB 4V6Q EM; 11.50 A; BH=2-177 # PDB 4V6R EM; 11.50 A; BH=2-177 # PDB 4V6S EM; 13.10 A; AH=2-177 # PDB 4V6T EM; 8.30 A; BG=2-177 # PDB 4V6V EM; 9.80 A; BH=2-177 # PDB 4V6Y EM; 12.00 A; BG=1-177 # PDB 4V6Z EM; 12.00 A; BG=1-177 # PDB 4V70 EM; 17.00 A; BG=1-177 # PDB 4V71 EM; 20.00 A; BG=1-177 # PDB 4V72 EM; 13.00 A; BG=1-177 # PDB 4V73 EM; 15.00 A; BG=1-177 # PDB 4V74 EM; 17.00 A; BG=1-177 # PDB 4V75 EM; 12.00 A; BG=1-177 # PDB 4V76 EM; 17.00 A; BG=1-177 # PDB 4V77 EM; 17.00 A; BG=1-177 # PDB 4V78 EM; 20.00 A; BG=1-177 # PDB 4V79 EM; 15.00 A; BG=1-177 # PDB 4V7A EM; 9.00 A; BG=1-177 # PDB 4V7B EM; 6.80 A; BG=1-177 # PDB 4V7C EM; 7.60 A; BH=2-177 # PDB 4V7D EM; 7.60 A; AH=2-177 # PDB 4V7I EM; 9.60 A; AG=1-177 # PDB 4V7S X-ray; 3.25 A; BG/DG=2-177 # PDB 4V7T X-ray; 3.19 A; BG/DG=2-177 # PDB 4V7U X-ray; 3.10 A; BG/DG=2-177 # PDB 4V7V X-ray; 3.29 A; BG/DG=2-177 # PDB 4V85 X-ray; 3.20 A; G=1-177 # PDB 4V89 X-ray; 3.70 A; BG=1-177 # PDB 4V9C X-ray; 3.30 A; BG/DG=1-177 # PDB 4V9D X-ray; 3.00 A; CG/DG=2-177 # PDB 4V9O X-ray; 2.90 A; AG/CG/EG/GG=1-177 # PDB 4V9P X-ray; 2.90 A; AG/CG/EG/GG=1-177 # PDB 4WF1 X-ray; 3.09 A; BG/DG=2-177 # PDB 4WOI X-ray; 3.00 A; BG/CG=1-177 # PDB 4WWW X-ray; 3.10 A; RG/YG=2-177 # PDB 4YBB X-ray; 2.10 A; CG/DG=2-177 # PDB 5ADY EM; 4.50 A; G=1-177 # PDB 5AFI EM; 2.90 A; G=1-177 # PDB 5AKA EM; 5.70 A; G=2-177 # PDB 5GAD EM; 3.70 A; G=1-177 # PDB 5GAE EM; 3.33 A; G=1-177 # PDB 5GAF EM; 4.30 A; G=2-177 # PDB 5GAG EM; 3.80 A; G=1-177 # PDB 5GAH EM; 3.80 A; G=1-177 # PDB 5IQR EM; 3.00 A; F=1-177 # PDB 5IT8 X-ray; 3.12 A; CG/DG=2-177 # PDB 5J5B X-ray; 2.80 A; CG/DG=2-177 # PDB 5J7L X-ray; 3.00 A; CG/DG=2-177 # PDB 5J88 X-ray; 3.32 A; CG/DG=2-177 # PDB 5J8A X-ray; 3.10 A; CG/DG=2-177 # PDB 5J91 X-ray; 2.96 A; CG/DG=2-177 # PDB 5JC9 X-ray; 3.03 A; CG/DG=2-177 # PDB 5JTE EM; 3.60 A; BG=1-177 # PDB 5JU8 EM; 3.60 A; BG=1-177 # PDB 5KCR EM; 3.60 A; 1H=1-177 # PDB 5KCS EM; 3.90 A; 1H=1-177 # PDB 5KPS EM; 3.90 A; F=1-177 # PDB 5KPV EM; 4.10 A; E=1-177 # PDB 5KPW EM; 3.90 A; E=1-177 # PDB 5KPX EM; 3.90 A; E=1-177 # PDB 5L3P EM; 3.70 A; H=1-177 # PIR D65123 R5EC6 # PIRSF PIRSF002162 Ribosomal_L6 # PRINTS PR00059 RIBOSOMALL6 # PROSITE PS00525 RIBOSOMAL_L6_1 # Pfam PF00347 Ribosomal_L6; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 50S ribosomal protein L6 {ECO:0000255|HAMAP-Rule MF_01365} # RefSeq NP_417764 NC_000913.3 # RefSeq WP_000091945 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein L6P family. {ECO:0000255|HAMAP-Rule MF_01365}. # SUBUNIT RL6_ECOLI Part of the 50S ribosomal subunit. # SUPFAM SSF56053 SSF56053; 2 # TIGRFAMs TIGR03654 L6_bact # eggNOG COG0097 LUCA # eggNOG ENOG4108R5J Bacteria BLAST swissprot:RL6_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RL6_ECOLI BioCyc ECOL316407:JW3267-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3267-MONOMER BioCyc EcoCyc:EG10869-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10869-MONOMER BioCyc MetaCyc:EG10869-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10869-MONOMER COG COG0097 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0097 DIP DIP-35860N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35860N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1006/jmbi.1998.1780 http://dx.doi.org/10.1006/jmbi.1998.1780 DOI 10.1006/jmbi.2000.3635 http://dx.doi.org/10.1006/jmbi.2000.3635 DOI 10.1016/S0092-8674(03)00427-6 http://dx.doi.org/10.1016/S0092-8674(03)00427-6 DOI 10.1016/j.celrep.2014.09.011 http://dx.doi.org/10.1016/j.celrep.2014.09.011 DOI 10.1021/bi00568a028 http://dx.doi.org/10.1021/bi00568a028 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/nar/11.9.2599 http://dx.doi.org/10.1093/nar/11.9.2599 DOI 10.1093/nar/9.17.4285 http://dx.doi.org/10.1093/nar/9.17.4285 DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pbio.1001866 http://dx.doi.org/10.1371/journal.pbio.1001866 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X01563 http://www.ebi.ac.uk/ena/data/view/X01563 EchoBASE EB0862 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0862 EcoGene EG10869 http://www.ecogene.org/geneInfo.php?eg_id=EG10869 EnsemblBacteria AAC76330 http://www.ensemblgenomes.org/id/AAC76330 EnsemblBacteria AAC76330 http://www.ensemblgenomes.org/id/AAC76330 EnsemblBacteria BAE77986 http://www.ensemblgenomes.org/id/BAE77986 EnsemblBacteria BAE77986 http://www.ensemblgenomes.org/id/BAE77986 EnsemblBacteria BAE77986 http://www.ensemblgenomes.org/id/BAE77986 EnsemblBacteria b3305 http://www.ensemblgenomes.org/id/b3305 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0022625 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022625 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GO_process GO:0002181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002181 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.90.930.12 http://www.cathdb.info/version/latest/superfamily/3.90.930.12 GeneID 947803 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947803 HAMAP MF_01365_B http://hamap.expasy.org/unirule/MF_01365_B HOGENOM HOG000039903 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000039903&db=HOGENOM6 InParanoid P0AG55 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AG55 IntAct P0AG55 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AG55* InterPro IPR000702 http://www.ebi.ac.uk/interpro/entry/IPR000702 InterPro IPR002358 http://www.ebi.ac.uk/interpro/entry/IPR002358 InterPro IPR019906 http://www.ebi.ac.uk/interpro/entry/IPR019906 InterPro IPR020040 http://www.ebi.ac.uk/interpro/entry/IPR020040 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW3267 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3267 KEGG_Gene eco:b3305 http://www.genome.jp/dbget-bin/www_bget?eco:b3305 KEGG_Orthology KO:K02933 http://www.genome.jp/dbget-bin/www_bget?KO:K02933 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 MINT MINT-1244940 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1244940 OMA DMPAGIT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DMPAGIT PANTHER PTHR11655 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11655 PDB 1EG0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1EG0 PDB 1ML5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ML5 PDB 2J28 http://www.ebi.ac.uk/pdbe-srv/view/entry/2J28 PDB 2RDO http://www.ebi.ac.uk/pdbe-srv/view/entry/2RDO PDB 3BBX http://www.ebi.ac.uk/pdbe-srv/view/entry/3BBX PDB 3J5L http://www.ebi.ac.uk/pdbe-srv/view/entry/3J5L PDB 3J7Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J7Z PDB 3J8G http://www.ebi.ac.uk/pdbe-srv/view/entry/3J8G PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 487D http://www.ebi.ac.uk/pdbe-srv/view/entry/487D PDB 4CSU http://www.ebi.ac.uk/pdbe-srv/view/entry/4CSU PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4UY8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4UY8 PDB 4V47 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V47 PDB 4V48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V48 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5ADY http://www.ebi.ac.uk/pdbe-srv/view/entry/5ADY PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5AKA http://www.ebi.ac.uk/pdbe-srv/view/entry/5AKA PDB 5GAD http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAD PDB 5GAE http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAE PDB 5GAF http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAF PDB 5GAG http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAG PDB 5GAH http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAH PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 1EG0 http://www.ebi.ac.uk/pdbsum/1EG0 PDBsum 1ML5 http://www.ebi.ac.uk/pdbsum/1ML5 PDBsum 2J28 http://www.ebi.ac.uk/pdbsum/2J28 PDBsum 2RDO http://www.ebi.ac.uk/pdbsum/2RDO PDBsum 3BBX http://www.ebi.ac.uk/pdbsum/3BBX PDBsum 3J5L http://www.ebi.ac.uk/pdbsum/3J5L PDBsum 3J7Z http://www.ebi.ac.uk/pdbsum/3J7Z PDBsum 3J8G http://www.ebi.ac.uk/pdbsum/3J8G PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 487D http://www.ebi.ac.uk/pdbsum/487D PDBsum 4CSU http://www.ebi.ac.uk/pdbsum/4CSU PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4UY8 http://www.ebi.ac.uk/pdbsum/4UY8 PDBsum 4V47 http://www.ebi.ac.uk/pdbsum/4V47 PDBsum 4V48 http://www.ebi.ac.uk/pdbsum/4V48 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5ADY http://www.ebi.ac.uk/pdbsum/5ADY PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5AKA http://www.ebi.ac.uk/pdbsum/5AKA PDBsum 5GAD http://www.ebi.ac.uk/pdbsum/5GAD PDBsum 5GAE http://www.ebi.ac.uk/pdbsum/5GAE PDBsum 5GAF http://www.ebi.ac.uk/pdbsum/5GAF PDBsum 5GAG http://www.ebi.ac.uk/pdbsum/5GAG PDBsum 5GAH http://www.ebi.ac.uk/pdbsum/5GAH PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PRINTS PR00059 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00059 PROSITE PS00525 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00525 PSORT swissprot:RL6_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RL6_ECOLI PSORT-B swissprot:RL6_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RL6_ECOLI PSORT2 swissprot:RL6_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RL6_ECOLI Pfam PF00347 http://pfam.xfam.org/family/PF00347 Phobius swissprot:RL6_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RL6_ECOLI PhylomeDB P0AG55 http://phylomedb.org/?seqid=P0AG55 ProteinModelPortal P0AG55 http://www.proteinmodelportal.org/query/uniprot/P0AG55 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 10756104 http://www.ncbi.nlm.nih.gov/pubmed/10756104 PubMed 12809609 http://www.ncbi.nlm.nih.gov/pubmed/12809609 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 24844575 http://www.ncbi.nlm.nih.gov/pubmed/24844575 PubMed 25310980 http://www.ncbi.nlm.nih.gov/pubmed/25310980 PubMed 324885 http://www.ncbi.nlm.nih.gov/pubmed/324885 PubMed 369594 http://www.ncbi.nlm.nih.gov/pubmed/369594 PubMed 6170935 http://www.ncbi.nlm.nih.gov/pubmed/6170935 PubMed 6222285 http://www.ncbi.nlm.nih.gov/pubmed/6222285 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9642068 http://www.ncbi.nlm.nih.gov/pubmed/9642068 RefSeq NP_417764 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417764 RefSeq WP_000091945 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000091945 SMR P0AG55 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AG55 STRING 511145.b3305 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3305&targetmode=cogs STRING COG0097 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0097&targetmode=cogs SUPFAM SSF56053 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56053 TIGRFAMs TIGR03654 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03654 UniProtKB RL6_ECOLI http://www.uniprot.org/uniprot/RL6_ECOLI UniProtKB-AC P0AG55 http://www.uniprot.org/uniprot/P0AG55 charge swissprot:RL6_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RL6_ECOLI eggNOG COG0097 http://eggnogapi.embl.de/nog_data/html/tree/COG0097 eggNOG ENOG4108R5J http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108R5J epestfind swissprot:RL6_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RL6_ECOLI garnier swissprot:RL6_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RL6_ECOLI helixturnhelix swissprot:RL6_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RL6_ECOLI hmoment swissprot:RL6_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RL6_ECOLI iep swissprot:RL6_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RL6_ECOLI inforesidue swissprot:RL6_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RL6_ECOLI octanol swissprot:RL6_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RL6_ECOLI pepcoil swissprot:RL6_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RL6_ECOLI pepdigest swissprot:RL6_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RL6_ECOLI pepinfo swissprot:RL6_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RL6_ECOLI pepnet swissprot:RL6_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RL6_ECOLI pepstats swissprot:RL6_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RL6_ECOLI pepwheel swissprot:RL6_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RL6_ECOLI pepwindow swissprot:RL6_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RL6_ECOLI sigcleave swissprot:RL6_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RL6_ECOLI ## Database ID URL or Descriptions # BioGrid 4260918 12 # EcoGene EG14190 eutQ # GO_process GO:0046336 ethanolamine catabolic process; IEA:UniProtKB-UniPathway. # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 2.60.120.10 -; 1. # INTERACTION EUTQ_ECOLI P77609 flxA; NbExp=3; IntAct=EBI-553018, EBI-553024; # IntAct P76555 12 # InterPro IPR010424 EutQ # InterPro IPR011051 RmlC_Cupin # InterPro IPR014710 RmlC-like_jellyroll # Organism EUTQ_ECOLI Escherichia coli (strain K12) # PATHWAY EUTQ_ECOLI Amine and polyamine degradation; ethanolamine degradation. # PATRIC 32120303 VBIEscCol129921_2554 # PIR C65021 C65021 # Pfam PF06249 EutQ # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EUTQ_ECOLI Ethanolamine utilization protein EutQ # RefSeq NP_416955 NC_000913.3 # RefSeq WP_000733906 NZ_LN832404.1 # SUPFAM SSF51182 SSF51182 # TCDB 9.B.75.2 the ethanol utilization/transport (eut) protein family # eggNOG COG4766 LUCA # eggNOG ENOG4105NDK Bacteria BLAST swissprot:EUTQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EUTQ_ECOLI BioCyc ECOL316407:JW2444-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2444-MONOMER BioCyc EcoCyc:G7290-MONOMER http://biocyc.org/getid?id=EcoCyc:G7290-MONOMER COG COG4766 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4766 DIP DIP-9540N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9540N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3942 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3942 EcoGene EG14190 http://www.ecogene.org/geneInfo.php?eg_id=EG14190 EnsemblBacteria AAC75513 http://www.ensemblgenomes.org/id/AAC75513 EnsemblBacteria AAC75513 http://www.ensemblgenomes.org/id/AAC75513 EnsemblBacteria BAE76718 http://www.ensemblgenomes.org/id/BAE76718 EnsemblBacteria BAE76718 http://www.ensemblgenomes.org/id/BAE76718 EnsemblBacteria BAE76718 http://www.ensemblgenomes.org/id/BAE76718 EnsemblBacteria b2460 http://www.ensemblgenomes.org/id/b2460 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0046336 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046336 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 2.60.120.10 http://www.cathdb.info/version/latest/superfamily/2.60.120.10 GeneID 946935 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946935 HOGENOM HOG000289625 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000289625&db=HOGENOM6 InParanoid P76555 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76555 IntAct P76555 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76555* InterPro IPR010424 http://www.ebi.ac.uk/interpro/entry/IPR010424 InterPro IPR011051 http://www.ebi.ac.uk/interpro/entry/IPR011051 InterPro IPR014710 http://www.ebi.ac.uk/interpro/entry/IPR014710 KEGG_Gene ecj:JW2444 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2444 KEGG_Gene eco:b2460 http://www.genome.jp/dbget-bin/www_bget?eco:b2460 KEGG_Orthology KO:K04030 http://www.genome.jp/dbget-bin/www_bget?KO:K04030 OMA IEFGTPS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IEFGTPS PSORT swissprot:EUTQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EUTQ_ECOLI PSORT-B swissprot:EUTQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EUTQ_ECOLI PSORT2 swissprot:EUTQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EUTQ_ECOLI Pfam PF06249 http://pfam.xfam.org/family/PF06249 Phobius swissprot:EUTQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EUTQ_ECOLI ProteinModelPortal P76555 http://www.proteinmodelportal.org/query/uniprot/P76555 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416955 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416955 RefSeq WP_000733906 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000733906 SMR P76555 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76555 STRING 511145.b2460 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2460&targetmode=cogs STRING COG4766 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4766&targetmode=cogs SUPFAM SSF51182 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51182 TCDB 9.B.75.2 http://www.tcdb.org/search/result.php?tc=9.B.75.2 UniProtKB EUTQ_ECOLI http://www.uniprot.org/uniprot/EUTQ_ECOLI UniProtKB-AC P76555 http://www.uniprot.org/uniprot/P76555 charge swissprot:EUTQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EUTQ_ECOLI eggNOG COG4766 http://eggnogapi.embl.de/nog_data/html/tree/COG4766 eggNOG ENOG4105NDK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105NDK epestfind swissprot:EUTQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EUTQ_ECOLI garnier swissprot:EUTQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EUTQ_ECOLI helixturnhelix swissprot:EUTQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EUTQ_ECOLI hmoment swissprot:EUTQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EUTQ_ECOLI iep swissprot:EUTQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EUTQ_ECOLI inforesidue swissprot:EUTQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EUTQ_ECOLI octanol swissprot:EUTQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EUTQ_ECOLI pepcoil swissprot:EUTQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EUTQ_ECOLI pepdigest swissprot:EUTQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EUTQ_ECOLI pepinfo swissprot:EUTQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EUTQ_ECOLI pepnet swissprot:EUTQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EUTQ_ECOLI pepstats swissprot:EUTQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EUTQ_ECOLI pepwheel swissprot:EUTQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EUTQ_ECOLI pepwindow swissprot:EUTQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EUTQ_ECOLI sigcleave swissprot:EUTQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EUTQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4263126 4 # EcoGene EG12094 sgrR # FUNCTION SGRR_ECOLI Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions; this repression likely provides one measure of control over sgrR at the level of synthesis. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain. {ECO 0000269|PubMed 15522088, ECO 0000269|PubMed 17209026}. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IBA:GO_Central. # GO_function GO:0000984 bacterial-type RNA polymerase regulatory region sequence-specific DNA binding; IDA:EcoCyc. # GO_function GO:0015197 peptide transporter activity; IBA:GO_Central. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-HAMAP. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IMP:EcoCyc. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # HAMAP MF_01449 HTH_type_SgrR # IntAct P33595 2 # InterPro IPR000914 SBP_5_dom # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR023767 Tscrpt_reg_SgrR # InterPro IPR025370 SgrR_HTH_N # KEGG_Brite ko03000 Transcription factors # MISCELLANEOUS SGRR_ECOLI Binds specifically to sgrS promoter in vitro. # Organism SGRR_ECOLI Escherichia coli (strain K12) # PATRIC 32115239 VBIEscCol129921_0071 # PIR E64728 E64728 # Pfam PF00496 SBP_bac_5 # Pfam PF12793 SgrR_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SGRR_ECOLI HTH-type transcriptional regulator SgrR # RefSeq NP_414611 NC_000913.3 # RefSeq WP_001138624 NZ_LN832404.1 # SIMILARITY Contains 1 HTH marR-type DNA-binding domain. {ECO 0000305}. # eggNOG COG4533 LUCA # eggNOG ENOG4105KNR Bacteria BLAST swissprot:SGRR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SGRR_ECOLI BioCyc ECOL316407:JW0068-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0068-MONOMER BioCyc EcoCyc:EG12094-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12094-MONOMER COG COG4533 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4533 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1111/j.1365-2958.2004.04348.x http://dx.doi.org/10.1111/j.1365-2958.2004.04348.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01689-06 http://dx.doi.org/10.1128/JB.01689-06 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2018 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2018 EcoGene EG12094 http://www.ecogene.org/geneInfo.php?eg_id=EG12094 EnsemblBacteria AAC73180 http://www.ensemblgenomes.org/id/AAC73180 EnsemblBacteria AAC73180 http://www.ensemblgenomes.org/id/AAC73180 EnsemblBacteria BAB96638 http://www.ensemblgenomes.org/id/BAB96638 EnsemblBacteria BAB96638 http://www.ensemblgenomes.org/id/BAB96638 EnsemblBacteria BAB96638 http://www.ensemblgenomes.org/id/BAB96638 EnsemblBacteria b0069 http://www.ensemblgenomes.org/id/b0069 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0000984 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000984 GO_function GO:0015197 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015197 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 944788 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944788 HAMAP MF_01449 http://hamap.expasy.org/unirule/MF_01449 HOGENOM HOG000271136 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000271136&db=HOGENOM6 InParanoid P33595 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33595 IntAct P33595 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33595* InterPro IPR000914 http://www.ebi.ac.uk/interpro/entry/IPR000914 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR023767 http://www.ebi.ac.uk/interpro/entry/IPR023767 InterPro IPR025370 http://www.ebi.ac.uk/interpro/entry/IPR025370 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW0068 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0068 KEGG_Gene eco:b0069 http://www.genome.jp/dbget-bin/www_bget?eco:b0069 KEGG_Orthology KO:K11925 http://www.genome.jp/dbget-bin/www_bget?KO:K11925 OMA ARPTHCE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ARPTHCE PSORT swissprot:SGRR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SGRR_ECOLI PSORT-B swissprot:SGRR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SGRR_ECOLI PSORT2 swissprot:SGRR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SGRR_ECOLI Pfam PF00496 http://pfam.xfam.org/family/PF00496 Pfam PF12793 http://pfam.xfam.org/family/PF12793 Phobius swissprot:SGRR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SGRR_ECOLI PhylomeDB P33595 http://phylomedb.org/?seqid=P33595 ProteinModelPortal P33595 http://www.proteinmodelportal.org/query/uniprot/P33595 PubMed 15522088 http://www.ncbi.nlm.nih.gov/pubmed/15522088 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17209026 http://www.ncbi.nlm.nih.gov/pubmed/17209026 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414611 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414611 RefSeq WP_001138624 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001138624 STRING 511145.b0069 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0069&targetmode=cogs STRING COG4533 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4533&targetmode=cogs UniProtKB SGRR_ECOLI http://www.uniprot.org/uniprot/SGRR_ECOLI UniProtKB-AC P33595 http://www.uniprot.org/uniprot/P33595 charge swissprot:SGRR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SGRR_ECOLI eggNOG COG4533 http://eggnogapi.embl.de/nog_data/html/tree/COG4533 eggNOG ENOG4105KNR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KNR epestfind swissprot:SGRR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SGRR_ECOLI garnier swissprot:SGRR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SGRR_ECOLI helixturnhelix swissprot:SGRR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SGRR_ECOLI hmoment swissprot:SGRR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SGRR_ECOLI iep swissprot:SGRR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SGRR_ECOLI inforesidue swissprot:SGRR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SGRR_ECOLI octanol swissprot:SGRR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SGRR_ECOLI pepcoil swissprot:SGRR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SGRR_ECOLI pepdigest swissprot:SGRR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SGRR_ECOLI pepinfo swissprot:SGRR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SGRR_ECOLI pepnet swissprot:SGRR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SGRR_ECOLI pepstats swissprot:SGRR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SGRR_ECOLI pepwheel swissprot:SGRR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SGRR_ECOLI pepwindow swissprot:SGRR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SGRR_ECOLI sigcleave swissprot:SGRR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SGRR_ECOLI ## Database ID URL or Descriptions # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # Organism YCHS_ECOLI Escherichia coli (strain K12) # PIR A64870 A64870 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCHS_ECOLI Putative uncharacterized protein YchS BLAST swissprot:YCHS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCHS_ECOLI BioCyc ECOL316407:JW5881-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5881-MONOMER BioCyc EcoCyc:G6631-MONOMER http://biocyc.org/getid?id=EcoCyc:G6631-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EnsemblBacteria BAA36098 http://www.ensemblgenomes.org/id/BAA36098 EnsemblBacteria BAA36098 http://www.ensemblgenomes.org/id/BAA36098 EnsemblBacteria BAA36098 http://www.ensemblgenomes.org/id/BAA36098 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv KEGG_Gene ecj:JW5881 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5881 OMA RIFNCGF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RIFNCGF PSORT swissprot:YCHS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCHS_ECOLI PSORT-B swissprot:YCHS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCHS_ECOLI PSORT2 swissprot:YCHS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCHS_ECOLI Phobius swissprot:YCHS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCHS_ECOLI ProteinModelPortal P76023 http://www.proteinmodelportal.org/query/uniprot/P76023 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 STRING 316407.85674881 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85674881&targetmode=cogs UniProtKB YCHS_ECOLI http://www.uniprot.org/uniprot/YCHS_ECOLI UniProtKB-AC P76023 http://www.uniprot.org/uniprot/P76023 charge swissprot:YCHS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCHS_ECOLI epestfind swissprot:YCHS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCHS_ECOLI garnier swissprot:YCHS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCHS_ECOLI helixturnhelix swissprot:YCHS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCHS_ECOLI hmoment swissprot:YCHS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCHS_ECOLI iep swissprot:YCHS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCHS_ECOLI inforesidue swissprot:YCHS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCHS_ECOLI octanol swissprot:YCHS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCHS_ECOLI pepcoil swissprot:YCHS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCHS_ECOLI pepdigest swissprot:YCHS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCHS_ECOLI pepinfo swissprot:YCHS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCHS_ECOLI pepnet swissprot:YCHS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCHS_ECOLI pepstats swissprot:YCHS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCHS_ECOLI pepwheel swissprot:YCHS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCHS_ECOLI pepwindow swissprot:YCHS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCHS_ECOLI sigcleave swissprot:YCHS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCHS_ECOLI ## Database ID URL or Descriptions # BRENDA 3.5.1.28 2026 # BioGrid 4259998 12 # CATALYTIC ACTIVITY AMID_ECOLI Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. # CDD cd06583 PGRP # COFACTOR AMID_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 20036252}; Note=Binds 1 zinc ion per subunit. {ECO 0000269|PubMed 20036252}; # EcoGene EG13687 amiD # GO_component GO:0009279 cell outer membrane; IEA:UniProtKB-SubCell. # GO_component GO:0019867 outer membrane; IDA:EcoliWiki. # GO_function GO:0008270 zinc ion binding; IDA:EcoliWiki. # GO_function GO:0008745 N-acetylmuramoyl-L-alanine amidase activity; IDA:EcoCyc. # GO_function GO:0009392 N-acetyl-anhydromuramoyl-L-alanine amidase activity; IDA:EcoCyc. # GO_process GO:0009253 peptidoglycan catabolic process; IDA:EcoCyc. # GO_process GO:0009254 peptidoglycan turnover; IBA:GO_Central. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 3.40.80.10 -; 1. # InterPro IPR002477 Peptidoglycan-bd-like # InterPro IPR002502 Amidase_domain # KEGG_Brite ko01000 Enzymes # Organism AMID_ECOLI Escherichia coli (strain K12) # PATRIC 32116941 VBIEscCol129921_0896 # PDB 2BH7 X-ray; 2.20 A; A=18-276 # PDB 2WKX X-ray; 1.80 A; A=18-276 # PDB 3D2Y X-ray; 1.75 A; A=18-276 # PDB 3D2Z X-ray; 2.80 A; A=18-276 # PIR C64825 C64825 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF01510 Amidase_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AMID_ECOLI N-acetylmuramoyl-L-alanine amidase AmiD # RefSeq NP_415388 NC_000913.3 # RefSeq WP_001252135 NZ_LN832404.1 # SIMILARITY Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. {ECO 0000305}. # SMART SM00644 Ami_2 # SUBCELLULAR LOCATION AMID_ECOLI Cell outer membrane {ECO 0000305}; Lipid- anchor {ECO 0000305}. # SUPFAM SSF47090 SSF47090 # SUPFAM SSF55846 SSF55846 # eggNOG COG3023 LUCA # eggNOG ENOG4108VBV Bacteria BLAST swissprot:AMID_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AMID_ECOLI BioCyc ECOL316407:JW0851-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0851-MONOMER BioCyc EcoCyc:G6452-MONOMER http://biocyc.org/getid?id=EcoCyc:G6452-MONOMER BioCyc MetaCyc:G6452-MONOMER http://biocyc.org/getid?id=MetaCyc:G6452-MONOMER COG COG3023 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3023 DOI 10.1016/j.jmb.2009.12.038 http://dx.doi.org/10.1016/j.jmb.2009.12.038 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.5.1.28 http://www.genome.jp/dbget-bin/www_bget?EC:3.5.1.28 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.5.1.28 http://enzyme.expasy.org/EC/3.5.1.28 EchoBASE EB3451 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3451 EcoGene EG13687 http://www.ecogene.org/geneInfo.php?eg_id=EG13687 EnsemblBacteria AAC73954 http://www.ensemblgenomes.org/id/AAC73954 EnsemblBacteria AAC73954 http://www.ensemblgenomes.org/id/AAC73954 EnsemblBacteria BAA35581 http://www.ensemblgenomes.org/id/BAA35581 EnsemblBacteria BAA35581 http://www.ensemblgenomes.org/id/BAA35581 EnsemblBacteria BAA35581 http://www.ensemblgenomes.org/id/BAA35581 EnsemblBacteria b0867 http://www.ensemblgenomes.org/id/b0867 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0019867 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019867 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0008745 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008745 GO_function GO:0009392 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009392 GO_process GO:0009253 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009253 GO_process GO:0009254 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009254 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 3.40.80.10 http://www.cathdb.info/version/latest/superfamily/3.40.80.10 GeneID 945494 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945494 HOGENOM HOG000255964 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000255964&db=HOGENOM6 InParanoid P75820 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75820 IntEnz 3.5.1.28 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.1.28 InterPro IPR002477 http://www.ebi.ac.uk/interpro/entry/IPR002477 InterPro IPR002502 http://www.ebi.ac.uk/interpro/entry/IPR002502 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0851 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0851 KEGG_Gene eco:b0867 http://www.genome.jp/dbget-bin/www_bget?eco:b0867 KEGG_Orthology KO:K11066 http://www.genome.jp/dbget-bin/www_bget?KO:K11066 OMA HFRPANY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HFRPANY PDB 2BH7 http://www.ebi.ac.uk/pdbe-srv/view/entry/2BH7 PDB 2WKX http://www.ebi.ac.uk/pdbe-srv/view/entry/2WKX PDB 3D2Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3D2Y PDB 3D2Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3D2Z PDBsum 2BH7 http://www.ebi.ac.uk/pdbsum/2BH7 PDBsum 2WKX http://www.ebi.ac.uk/pdbsum/2WKX PDBsum 3D2Y http://www.ebi.ac.uk/pdbsum/3D2Y PDBsum 3D2Z http://www.ebi.ac.uk/pdbsum/3D2Z PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:AMID_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AMID_ECOLI PSORT-B swissprot:AMID_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AMID_ECOLI PSORT2 swissprot:AMID_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AMID_ECOLI Pfam PF01510 http://pfam.xfam.org/family/PF01510 Phobius swissprot:AMID_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AMID_ECOLI PhylomeDB P75820 http://phylomedb.org/?seqid=P75820 ProteinModelPortal P75820 http://www.proteinmodelportal.org/query/uniprot/P75820 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20036252 http://www.ncbi.nlm.nih.gov/pubmed/20036252 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415388 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415388 RefSeq WP_001252135 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001252135 SMART SM00644 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00644 SMR P75820 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75820 STRING 511145.b0867 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0867&targetmode=cogs STRING COG3023 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3023&targetmode=cogs SUPFAM SSF47090 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47090 SUPFAM SSF55846 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55846 UniProtKB AMID_ECOLI http://www.uniprot.org/uniprot/AMID_ECOLI UniProtKB-AC P75820 http://www.uniprot.org/uniprot/P75820 charge swissprot:AMID_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AMID_ECOLI eggNOG COG3023 http://eggnogapi.embl.de/nog_data/html/tree/COG3023 eggNOG ENOG4108VBV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108VBV epestfind swissprot:AMID_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AMID_ECOLI garnier swissprot:AMID_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AMID_ECOLI helixturnhelix swissprot:AMID_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AMID_ECOLI hmoment swissprot:AMID_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AMID_ECOLI iep swissprot:AMID_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AMID_ECOLI inforesidue swissprot:AMID_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AMID_ECOLI octanol swissprot:AMID_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AMID_ECOLI pepcoil swissprot:AMID_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AMID_ECOLI pepdigest swissprot:AMID_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AMID_ECOLI pepinfo swissprot:AMID_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AMID_ECOLI pepnet swissprot:AMID_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AMID_ECOLI pepstats swissprot:AMID_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AMID_ECOLI pepwheel swissprot:AMID_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AMID_ECOLI pepwindow swissprot:AMID_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AMID_ECOLI sigcleave swissprot:AMID_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AMID_ECOLI ## Database ID URL or Descriptions # BioGrid 4261138 11 # EcoGene EG13800 ydeR # GO_component GO:0009289 pilus; IEA:UniProtKB-SubCell. # GO_process GO:0007155 cell adhesion; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0007155 cell adhesion # Gene3D 2.60.40.1090 -; 1. # InterPro IPR000259 Adhesion_dom_fimbrial # InterPro IPR008966 Adhesion_dom # Organism YDER_ECOLI Escherichia coli (strain K12) # PATRIC 32118300 VBIEscCol129921_1570 # PIR B64904 B64904 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDER_ECOLI Uncharacterized fimbrial-like protein YdeR # RefSeq NP_416020 NC_000913.3 # RefSeq WP_000825452 NZ_LN832404.1 # SIMILARITY Belongs to the fimbrial protein family. {ECO 0000305}. # SUBCELLULAR LOCATION YDER_ECOLI Fimbrium {ECO 0000305}. # SUPFAM SSF49401 SSF49401 # eggNOG ENOG4106318 Bacteria # eggNOG ENOG4112C98 LUCA BLAST swissprot:YDER_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDER_ECOLI BioCyc ECOL316407:JW1497-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1497-MONOMER BioCyc EcoCyc:G6793-MONOMER http://biocyc.org/getid?id=EcoCyc:G6793-MONOMER DIP DIP-11685N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11685N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3561 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3561 EcoGene EG13800 http://www.ecogene.org/geneInfo.php?eg_id=EG13800 EnsemblBacteria AAC74576 http://www.ensemblgenomes.org/id/AAC74576 EnsemblBacteria AAC74576 http://www.ensemblgenomes.org/id/AAC74576 EnsemblBacteria BAA15176 http://www.ensemblgenomes.org/id/BAA15176 EnsemblBacteria BAA15176 http://www.ensemblgenomes.org/id/BAA15176 EnsemblBacteria BAA15176 http://www.ensemblgenomes.org/id/BAA15176 EnsemblBacteria b1503 http://www.ensemblgenomes.org/id/b1503 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009289 GO_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 Gene3D 2.60.40.1090 http://www.cathdb.info/version/latest/superfamily/2.60.40.1090 GeneID 946049 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946049 HOGENOM HOG000260127 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260127&db=HOGENOM6 InParanoid P77294 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77294 InterPro IPR000259 http://www.ebi.ac.uk/interpro/entry/IPR000259 InterPro IPR008966 http://www.ebi.ac.uk/interpro/entry/IPR008966 KEGG_Gene ecj:JW1497 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1497 KEGG_Gene eco:b1503 http://www.genome.jp/dbget-bin/www_bget?eco:b1503 OMA YYKNEGS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YYKNEGS PSORT swissprot:YDER_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDER_ECOLI PSORT-B swissprot:YDER_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDER_ECOLI PSORT2 swissprot:YDER_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDER_ECOLI Phobius swissprot:YDER_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDER_ECOLI PhylomeDB P77294 http://phylomedb.org/?seqid=P77294 ProteinModelPortal P77294 http://www.proteinmodelportal.org/query/uniprot/P77294 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416020 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416020 RefSeq WP_000825452 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000825452 SMR P77294 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77294 STRING 511145.b1503 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1503&targetmode=cogs SUPFAM SSF49401 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49401 UniProtKB YDER_ECOLI http://www.uniprot.org/uniprot/YDER_ECOLI UniProtKB-AC P77294 http://www.uniprot.org/uniprot/P77294 charge swissprot:YDER_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDER_ECOLI eggNOG ENOG4106318 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106318 eggNOG ENOG4112C98 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4112C98 epestfind swissprot:YDER_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDER_ECOLI garnier swissprot:YDER_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDER_ECOLI helixturnhelix swissprot:YDER_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDER_ECOLI hmoment swissprot:YDER_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDER_ECOLI iep swissprot:YDER_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDER_ECOLI inforesidue swissprot:YDER_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDER_ECOLI octanol swissprot:YDER_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDER_ECOLI pepcoil swissprot:YDER_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDER_ECOLI pepdigest swissprot:YDER_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDER_ECOLI pepinfo swissprot:YDER_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDER_ECOLI pepnet swissprot:YDER_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDER_ECOLI pepstats swissprot:YDER_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDER_ECOLI pepwheel swissprot:YDER_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDER_ECOLI pepwindow swissprot:YDER_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDER_ECOLI sigcleave swissprot:YDER_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDER_ECOLI ## Database ID URL or Descriptions # FUNCTION IND11_ECOLI Involved in the transposition of the insertion sequence IS2. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006310 DNA recombination; IEA:UniProtKB-KW. # GO_process GO:0015074 DNA integration; IEA:InterPro. # GO_process GO:0032196 transposition; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 3.30.420.10 -; 1. # InterPro IPR001584 Integrase_cat-core # InterPro IPR012337 RNaseH-like_dom # InterPro IPR025948 HTH-like_dom # Organism IND11_ECOLI Escherichia coli (strain K12) # PATRIC 48661345 VBIEscCol107702_1042 # PROSITE PS50994 INTEGRASE # Pfam PF00665 rve # Pfam PF13276 HTH_21 # RecName IND11_ECOLI Transposase InsD for insertion element IS2-11 # SIMILARITY Contains 1 integrase catalytic domain. {ECO:0000255|PROSITE-ProRule PRU00457}. # SUPFAM SSF53098 SSF53098 # eggNOG ENOG4108MVM Bacteria # eggNOG ENOG410Z4Y8 LUCA BLAST swissprot:IND11_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:IND11_ECOLI DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EnsemblBacteria BAA16002 http://www.ensemblgenomes.org/id/BAA16002 EnsemblBacteria BAA16002 http://www.ensemblgenomes.org/id/BAA16002 EnsemblBacteria BAA16002 http://www.ensemblgenomes.org/id/BAA16002 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0015074 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015074 GO_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 3.30.420.10 http://www.cathdb.info/version/latest/superfamily/3.30.420.10 InterPro IPR001584 http://www.ebi.ac.uk/interpro/entry/IPR001584 InterPro IPR012337 http://www.ebi.ac.uk/interpro/entry/IPR012337 InterPro IPR025948 http://www.ebi.ac.uk/interpro/entry/IPR025948 KEGG_Gene ecj:JW5918 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5918 PROSITE PS50994 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50994 PSORT swissprot:IND11_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:IND11_ECOLI PSORT-B swissprot:IND11_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:IND11_ECOLI PSORT2 swissprot:IND11_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:IND11_ECOLI Pfam PF00665 http://pfam.xfam.org/family/PF00665 Pfam PF13276 http://pfam.xfam.org/family/PF13276 Phobius swissprot:IND11_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:IND11_ECOLI PhylomeDB P0CF63 http://phylomedb.org/?seqid=P0CF63 ProteinModelPortal P0CF63 http://www.proteinmodelportal.org/query/uniprot/P0CF63 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 SMR P0CF63 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0CF63 STRING 511145.b4273 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4273&targetmode=cogs SUPFAM SSF53098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098 UniProtKB IND11_ECOLI http://www.uniprot.org/uniprot/IND11_ECOLI UniProtKB-AC P0CF63 http://www.uniprot.org/uniprot/P0CF63 charge swissprot:IND11_ECOLI http://rest.g-language.org/emboss/charge/swissprot:IND11_ECOLI eggNOG ENOG4108MVM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MVM eggNOG ENOG410Z4Y8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Z4Y8 epestfind swissprot:IND11_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:IND11_ECOLI garnier swissprot:IND11_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:IND11_ECOLI helixturnhelix swissprot:IND11_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:IND11_ECOLI hmoment swissprot:IND11_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:IND11_ECOLI iep swissprot:IND11_ECOLI http://rest.g-language.org/emboss/iep/swissprot:IND11_ECOLI inforesidue swissprot:IND11_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:IND11_ECOLI octanol swissprot:IND11_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:IND11_ECOLI pepcoil swissprot:IND11_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:IND11_ECOLI pepdigest swissprot:IND11_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:IND11_ECOLI pepinfo swissprot:IND11_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:IND11_ECOLI pepnet swissprot:IND11_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:IND11_ECOLI pepstats swissprot:IND11_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:IND11_ECOLI pepwheel swissprot:IND11_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:IND11_ECOLI pepwindow swissprot:IND11_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:IND11_ECOLI sigcleave swissprot:IND11_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:IND11_ECOLI ## Database ID URL or Descriptions # BioGrid 4260310 19 # CDD cd06660 Aldo_ket_red # EcoGene EG13491 yeaE # GO_function GO:0016491 oxidoreductase activity; IDA:EcoCyc. # GO_process GO:0051596 methylglyoxal catabolic process; IDA:EcoCyc. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.100 -; 1. # IntAct P76234 4 # InterPro IPR001395 Aldo/ket_red/Kv-b # InterPro IPR020471 Aldo/keto_reductase # InterPro IPR023210 NADP_OxRdtase_dom # Organism YEAE_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11732 PTHR11732 # PATRIC 32118873 VBIEscCol129921_1854 # PIR E64938 E64938 # PRINTS PR00069 ALDKETRDTASE # Pfam PF00248 Aldo_ket_red # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEAE_ECOLI Uncharacterized protein YeaE # RefSeq NP_416295 NC_000913.3 # RefSeq WP_001186371 NZ_LN832404.1 # SUPFAM SSF51430 SSF51430 # eggNOG COG0656 LUCA # eggNOG ENOG4105CV8 Bacteria BLAST swissprot:YEAE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEAE_ECOLI BioCyc ECOL316407:JW1770-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1770-MONOMER BioCyc EcoCyc:G6967-MONOMER http://biocyc.org/getid?id=EcoCyc:G6967-MONOMER BioCyc MetaCyc:G6967-MONOMER http://biocyc.org/getid?id=MetaCyc:G6967-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3264 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3264 EcoGene EG13491 http://www.ecogene.org/geneInfo.php?eg_id=EG13491 EnsemblBacteria AAC74851 http://www.ensemblgenomes.org/id/AAC74851 EnsemblBacteria AAC74851 http://www.ensemblgenomes.org/id/AAC74851 EnsemblBacteria BAA15578 http://www.ensemblgenomes.org/id/BAA15578 EnsemblBacteria BAA15578 http://www.ensemblgenomes.org/id/BAA15578 EnsemblBacteria BAA15578 http://www.ensemblgenomes.org/id/BAA15578 EnsemblBacteria b1781 http://www.ensemblgenomes.org/id/b1781 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_process GO:0051596 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051596 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.100 http://www.cathdb.info/version/latest/superfamily/3.20.20.100 GeneID 946302 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946302 HOGENOM HOG000250278 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000250278&db=HOGENOM6 InParanoid P76234 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76234 IntAct P76234 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76234* InterPro IPR001395 http://www.ebi.ac.uk/interpro/entry/IPR001395 InterPro IPR020471 http://www.ebi.ac.uk/interpro/entry/IPR020471 InterPro IPR023210 http://www.ebi.ac.uk/interpro/entry/IPR023210 KEGG_Gene ecj:JW1770 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1770 KEGG_Gene eco:b1781 http://www.genome.jp/dbget-bin/www_bget?eco:b1781 OMA INEMVNQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=INEMVNQ PANTHER PTHR11732 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11732 PRINTS PR00069 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00069 PSORT swissprot:YEAE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEAE_ECOLI PSORT-B swissprot:YEAE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEAE_ECOLI PSORT2 swissprot:YEAE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEAE_ECOLI Pfam PF00248 http://pfam.xfam.org/family/PF00248 Phobius swissprot:YEAE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEAE_ECOLI PhylomeDB P76234 http://phylomedb.org/?seqid=P76234 ProteinModelPortal P76234 http://www.proteinmodelportal.org/query/uniprot/P76234 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416295 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416295 RefSeq WP_001186371 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001186371 SMR P76234 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76234 STRING 511145.b1781 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1781&targetmode=cogs SUPFAM SSF51430 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51430 UniProtKB YEAE_ECOLI http://www.uniprot.org/uniprot/YEAE_ECOLI UniProtKB-AC P76234 http://www.uniprot.org/uniprot/P76234 charge swissprot:YEAE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEAE_ECOLI eggNOG COG0656 http://eggnogapi.embl.de/nog_data/html/tree/COG0656 eggNOG ENOG4105CV8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CV8 epestfind swissprot:YEAE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEAE_ECOLI garnier swissprot:YEAE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEAE_ECOLI helixturnhelix swissprot:YEAE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEAE_ECOLI hmoment swissprot:YEAE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEAE_ECOLI iep swissprot:YEAE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEAE_ECOLI inforesidue swissprot:YEAE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEAE_ECOLI octanol swissprot:YEAE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEAE_ECOLI pepcoil swissprot:YEAE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEAE_ECOLI pepdigest swissprot:YEAE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEAE_ECOLI pepinfo swissprot:YEAE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEAE_ECOLI pepnet swissprot:YEAE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEAE_ECOLI pepstats swissprot:YEAE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEAE_ECOLI pepwheel swissprot:YEAE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEAE_ECOLI pepwindow swissprot:YEAE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEAE_ECOLI sigcleave swissprot:YEAE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEAE_ECOLI ## Database ID URL or Descriptions # AltName META_ECOLI Homoserine O-transsuccinylase # BioGrid 4259289 12 # CATALYTIC ACTIVITY META_ECOLI Succinyl-CoA + L-homoserine = CoA + O- succinyl-L-homoserine. # CDD cd03131 GATase1_HTS # ENZYME REGULATION META_ECOLI Allosterically inhibited by SAM and methionine. # EcoGene EG10581 metA # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0008899 homoserine O-succinyltransferase activity; IDA:EcoCyc. # GO_process GO:0019281 L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.880 -; 1. # HAMAP MF_00295 Homoser_O_succinyltr # IntAct P07623 2 # InterPro IPR005697 Homserine_suc_trans # InterPro IPR029062 Class_I_gatase-like # InterPro IPR033752 HTS_family # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00270 Cysteine and methionine metabolism # KEGG_Pathway ko00920 Sulfur metabolism # Organism META_ECOLI Escherichia coli (strain K12) # PANTHER PTHR20919 PTHR20919 # PATHWAY Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; O-succinyl-L-homoserine from L-homoserine step 1/1. # PATRIC 32123553 VBIEscCol129921_4125 # PIR D65208 XYECM # PIRSF PIRSF000450 H_ser_succinyltr # Pfam PF04204 HTS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName META_ECOLI Homoserine O-succinyltransferase # RefSeq NP_418437 NC_000913.3 # RefSeq WP_001122779 NZ_LN832404.1 # SIMILARITY Belongs to the HTS family. {ECO 0000305}. # SUBCELLULAR LOCATION META_ECOLI Cytoplasm. # SUBUNIT META_ECOLI Homodimer. # SUPFAM SSF52317 SSF52317 # TIGRFAMs TIGR01001 metA # UniPathway UPA00051 UER00075 # eggNOG COG1897 LUCA # eggNOG ENOG4105CVG Bacteria BLAST swissprot:META_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:META_ECOLI BioCyc ECOL316407:JW3973-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3973-MONOMER BioCyc EcoCyc:HOMSUCTRAN-MONOMER http://biocyc.org/getid?id=EcoCyc:HOMSUCTRAN-MONOMER BioCyc MetaCyc:HOMSUCTRAN-MONOMER http://biocyc.org/getid?id=MetaCyc:HOMSUCTRAN-MONOMER COG COG1897 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1897 DOI 10.1021/bi991710o http://dx.doi.org/10.1021/bi991710o DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/16.19.9342 http://dx.doi.org/10.1093/nar/16.19.9342 DOI 10.1093/nar/17.7.2856 http://dx.doi.org/10.1093/nar/17.7.2856 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.46 http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.46 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M10210 http://www.ebi.ac.uk/ena/data/view/M10210 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X12431 http://www.ebi.ac.uk/ena/data/view/X12431 EMBL X14501 http://www.ebi.ac.uk/ena/data/view/X14501 ENZYME 2.3.1.46 http://enzyme.expasy.org/EC/2.3.1.46 EchoBASE EB0576 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0576 EcoGene EG10581 http://www.ecogene.org/geneInfo.php?eg_id=EG10581 EnsemblBacteria AAC76983 http://www.ensemblgenomes.org/id/AAC76983 EnsemblBacteria AAC76983 http://www.ensemblgenomes.org/id/AAC76983 EnsemblBacteria BAE78015 http://www.ensemblgenomes.org/id/BAE78015 EnsemblBacteria BAE78015 http://www.ensemblgenomes.org/id/BAE78015 EnsemblBacteria BAE78015 http://www.ensemblgenomes.org/id/BAE78015 EnsemblBacteria b4013 http://www.ensemblgenomes.org/id/b4013 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0008899 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008899 GO_process GO:0019281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019281 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.880 http://www.cathdb.info/version/latest/superfamily/3.40.50.880 GeneID 948513 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948513 HAMAP MF_00295 http://hamap.expasy.org/unirule/MF_00295 HOGENOM HOG000115049 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000115049&db=HOGENOM6 InParanoid P07623 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P07623 IntAct P07623 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P07623* IntEnz 2.3.1.46 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.46 InterPro IPR005697 http://www.ebi.ac.uk/interpro/entry/IPR005697 InterPro IPR029062 http://www.ebi.ac.uk/interpro/entry/IPR029062 InterPro IPR033752 http://www.ebi.ac.uk/interpro/entry/IPR033752 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3973 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3973 KEGG_Gene eco:b4013 http://www.genome.jp/dbget-bin/www_bget?eco:b4013 KEGG_Orthology KO:K00651 http://www.genome.jp/dbget-bin/www_bget?KO:K00651 KEGG_Pathway ko00270 http://www.genome.jp/kegg-bin/show_pathway?ko00270 KEGG_Pathway ko00920 http://www.genome.jp/kegg-bin/show_pathway?ko00920 KEGG_Reaction rn:R01777 http://www.genome.jp/dbget-bin/www_bget?rn:R01777 MINT MINT-1343536 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1343536 OMA WRSHRNL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WRSHRNL PANTHER PTHR20919 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20919 PSORT swissprot:META_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:META_ECOLI PSORT-B swissprot:META_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:META_ECOLI PSORT2 swissprot:META_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:META_ECOLI Pfam PF04204 http://pfam.xfam.org/family/PF04204 Phobius swissprot:META_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:META_ECOLI PhylomeDB P07623 http://phylomedb.org/?seqid=P07623 ProteinModelPortal P07623 http://www.proteinmodelportal.org/query/uniprot/P07623 PubMed 10572016 http://www.ncbi.nlm.nih.gov/pubmed/10572016 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2654885 http://www.ncbi.nlm.nih.gov/pubmed/2654885 PubMed 3050899 http://www.ncbi.nlm.nih.gov/pubmed/3050899 PubMed 6094503 http://www.ncbi.nlm.nih.gov/pubmed/6094503 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418437 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418437 RefSeq WP_001122779 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001122779 SMR P07623 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P07623 STRING 511145.b4013 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4013&targetmode=cogs STRING COG1897 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1897&targetmode=cogs SUPFAM SSF52317 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52317 TIGRFAMs TIGR01001 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01001 UniProtKB META_ECOLI http://www.uniprot.org/uniprot/META_ECOLI UniProtKB-AC P07623 http://www.uniprot.org/uniprot/P07623 charge swissprot:META_ECOLI http://rest.g-language.org/emboss/charge/swissprot:META_ECOLI eggNOG COG1897 http://eggnogapi.embl.de/nog_data/html/tree/COG1897 eggNOG ENOG4105CVG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CVG epestfind swissprot:META_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:META_ECOLI garnier swissprot:META_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:META_ECOLI helixturnhelix swissprot:META_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:META_ECOLI hmoment swissprot:META_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:META_ECOLI iep swissprot:META_ECOLI http://rest.g-language.org/emboss/iep/swissprot:META_ECOLI inforesidue swissprot:META_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:META_ECOLI octanol swissprot:META_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:META_ECOLI pepcoil swissprot:META_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:META_ECOLI pepdigest swissprot:META_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:META_ECOLI pepinfo swissprot:META_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:META_ECOLI pepnet swissprot:META_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:META_ECOLI pepstats swissprot:META_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:META_ECOLI pepwheel swissprot:META_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:META_ECOLI pepwindow swissprot:META_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:META_ECOLI sigcleave swissprot:META_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:META_ECOLI ## Database ID URL or Descriptions # BioGrid 4261886 315 # DOMAIN FTSA_ECOLI The extreme C-terminus is essential for localization to the membrane and the Z ring, self-interaction and activity. {ECO 0000269|PubMed 11053380, ECO 0000269|PubMed 15752196}. # EcoGene EG10339 ftsA # FUNCTION FTSA_ECOLI Essential cell division protein that assists in the assembly of the Z ring (PubMed 11847116). May serve as the principal membrane anchor for the Z ring (PubMed 15752196). Also required for the recruitment to the septal ring of the downstream cell division proteins FtsK, FtsQ, FtsL, FtsI and FtsN (PubMed 9282742, PubMed 9495771, PubMed 9603865, PubMed 9882666, PubMed 10027987, PubMed 24750258). Binds ATP (PubMed 11053380). {ECO 0000269|PubMed 10027987, ECO 0000269|PubMed 11053380, ECO 0000269|PubMed 11847116, ECO 0000269|PubMed 15752196, ECO 0000269|PubMed 24750258, ECO 0000269|PubMed 9282742, ECO 0000269|PubMed 9495771, ECO 0000269|PubMed 9603865, ECO 0000269|PubMed 9882666}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0009898 cytoplasmic side of plasma membrane; IDA:EcoCyc. # GO_component GO:0032153 cell division site; IDA:EcoliWiki. # GO_function GO:0005524 ATP binding; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IMP:EcoCyc. # GO_process GO:0043093 FtsZ-dependent cytokinesis; IEA:UniProtKB-HAMAP. # GO_process GO:0051301 cell division; IMP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0051301 cell division # HAMAP MF_02033 FtsA # INTERACTION FTSA_ECOLI Self; NbExp=4; IntAct=EBI-550562, EBI-550562; P29131 ftsN; NbExp=7; IntAct=EBI-550562, EBI-1134233; P0A9A6 ftsZ; NbExp=6; IntAct=EBI-550562, EBI-370963; # IntAct P0ABH0 26 # InterPro IPR003494 SHS2_FtsA # InterPro IPR020823 Cell_div_FtsA # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko03036 Chromosome # KEGG_Pathway ko04112 Cell cycle - Caulobacter # Organism FTSA_ECOLI Escherichia coli (strain K12) # PATRIC 32115293 VBIEscCol129921_0098 # PIR B23318 CEECA # PIRSF PIRSF003101 FtsA # Pfam PF02491 SHS2_FTSA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Cell division protein FtsA {ECO:0000255|HAMAP-Rule MF_02033} # RefSeq NP_414636 NC_000913.3 # RefSeq WP_000588474 NZ_LN832404.1 # SIMILARITY Belongs to the FtsA/MreB family. {ECO:0000255|HAMAP- Rule MF_02033, ECO:0000305}. # SMART SM00842 FtsA # SUBCELLULAR LOCATION FTSA_ECOLI Cell inner membrane {ECO 0000269|PubMed 15752196, ECO 0000269|PubMed 2203741}; Peripheral membrane protein {ECO 0000269|PubMed 15752196, ECO 0000269|PubMed 2203741}; Cytoplasmic side {ECO 0000269|PubMed 15752196, ECO 0000269|PubMed 2203741}. Note=Localizes to the Z ring in an FtsZ-dependent manner (PubMed 8955398, PubMed 8917533, PubMed 9495771). Targeted to the membrane through a conserved C-terminal amphiphatic helix (PubMed 15752196). {ECO 0000269|PubMed 15752196, ECO 0000269|PubMed 8917533, ECO 0000269|PubMed 8955398, ECO 0000269|PubMed 9495771}. # SUBUNIT FTSA_ECOLI Self-interacts (PubMed 11053380, PubMed 17501933). Interacts with FtsZ. This interaction plays an essential role in cell division (PubMed 8917533, PubMed 17501933). Interacts directly with the cytoplasmic region of FtsN (PubMed 22328664, PubMed 24750258). {ECO 0000269|PubMed 11053380, ECO 0000269|PubMed 17501933, ECO 0000269|PubMed 22328664, ECO 0000269|PubMed 24750258, ECO 0000269|PubMed 8917533}. # TIGRFAMs TIGR01174 ftsA # eggNOG COG0849 LUCA # eggNOG ENOG4105CIT Bacteria BLAST swissprot:FTSA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FTSA_ECOLI BioCyc ECOL316407:JW0092-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0092-MONOMER BioCyc EcoCyc:EG10339-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10339-MONOMER COG COG0849 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0849 DIP DIP-47983N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47983N DOI 10.1016/0022-2836(85)90290-6 http://dx.doi.org/10.1016/0022-2836(85)90290-6 DOI 10.1016/0378-1119(85)90179-9 http://dx.doi.org/10.1016/0378-1119(85)90179-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1997.4641833.x http://dx.doi.org/10.1046/j.1365-2958.1997.4641833.x DOI 10.1046/j.1365-2958.1999.01213.x http://dx.doi.org/10.1046/j.1365-2958.1999.01213.x DOI 10.1073/pnas.93.23.12998 http://dx.doi.org/10.1073/pnas.93.23.12998 DOI 10.1093/emboj/21.4.685 http://dx.doi.org/10.1093/emboj/21.4.685 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1111/j.1365-2958.1988.tb00066.x http://dx.doi.org/10.1111/j.1365-2958.1988.tb00066.x DOI 10.1111/j.1365-2958.2005.04522.x http://dx.doi.org/10.1111/j.1365-2958.2005.04522.x DOI 10.1111/j.1365-2958.2007.05735.x http://dx.doi.org/10.1111/j.1365-2958.2007.05735.x DOI 10.1111/mmi.12623 http://dx.doi.org/10.1111/mmi.12623 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.06683-11 http://dx.doi.org/10.1128/JB.06683-11 DOI 10.1128/JB.182.22.6366-6373.2000 http://dx.doi.org/10.1128/JB.182.22.6366-6373.2000 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K02668 http://www.ebi.ac.uk/ena/data/view/K02668 EMBL M36531 http://www.ebi.ac.uk/ena/data/view/M36531 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X55034 http://www.ebi.ac.uk/ena/data/view/X55034 EchoBASE EB0335 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0335 EcoGene EG10339 http://www.ecogene.org/geneInfo.php?eg_id=EG10339 EnsemblBacteria AAC73205 http://www.ensemblgenomes.org/id/AAC73205 EnsemblBacteria AAC73205 http://www.ensemblgenomes.org/id/AAC73205 EnsemblBacteria BAB96662 http://www.ensemblgenomes.org/id/BAB96662 EnsemblBacteria BAB96662 http://www.ensemblgenomes.org/id/BAB96662 EnsemblBacteria BAB96662 http://www.ensemblgenomes.org/id/BAB96662 EnsemblBacteria b0094 http://www.ensemblgenomes.org/id/b0094 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0009898 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009898 GO_component GO:0032153 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032153 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0043093 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043093 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GeneID 944778 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944778 HAMAP MF_02033 http://hamap.expasy.org/unirule/MF_02033 HOGENOM HOG000049205 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000049205&db=HOGENOM6 InParanoid P0ABH0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABH0 IntAct P0ABH0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABH0* InterPro IPR003494 http://www.ebi.ac.uk/interpro/entry/IPR003494 InterPro IPR020823 http://www.ebi.ac.uk/interpro/entry/IPR020823 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene ecj:JW0092 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0092 KEGG_Gene eco:b0094 http://www.genome.jp/dbget-bin/www_bget?eco:b0094 KEGG_Orthology KO:K03590 http://www.genome.jp/dbget-bin/www_bget?KO:K03590 KEGG_Pathway ko04112 http://www.genome.jp/kegg-bin/show_pathway?ko04112 OMA VIPFGGN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VIPFGGN PSORT swissprot:FTSA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FTSA_ECOLI PSORT-B swissprot:FTSA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FTSA_ECOLI PSORT2 swissprot:FTSA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FTSA_ECOLI Pfam PF02491 http://pfam.xfam.org/family/PF02491 Phobius swissprot:FTSA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FTSA_ECOLI PhylomeDB P0ABH0 http://phylomedb.org/?seqid=P0ABH0 ProteinModelPortal P0ABH0 http://www.proteinmodelportal.org/query/uniprot/P0ABH0 PubMed 10027987 http://www.ncbi.nlm.nih.gov/pubmed/10027987 PubMed 11053380 http://www.ncbi.nlm.nih.gov/pubmed/11053380 PubMed 11847116 http://www.ncbi.nlm.nih.gov/pubmed/11847116 PubMed 15752196 http://www.ncbi.nlm.nih.gov/pubmed/15752196 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17501933 http://www.ncbi.nlm.nih.gov/pubmed/17501933 PubMed 2203741 http://www.ncbi.nlm.nih.gov/pubmed/2203741 PubMed 2228979 http://www.ncbi.nlm.nih.gov/pubmed/2228979 PubMed 22328664 http://www.ncbi.nlm.nih.gov/pubmed/22328664 PubMed 24750258 http://www.ncbi.nlm.nih.gov/pubmed/24750258 PubMed 2846985 http://www.ncbi.nlm.nih.gov/pubmed/2846985 PubMed 2995680 http://www.ncbi.nlm.nih.gov/pubmed/2995680 PubMed 3000876 http://www.ncbi.nlm.nih.gov/pubmed/3000876 PubMed 6094474 http://www.ncbi.nlm.nih.gov/pubmed/6094474 PubMed 8917533 http://www.ncbi.nlm.nih.gov/pubmed/8917533 PubMed 8955398 http://www.ncbi.nlm.nih.gov/pubmed/8955398 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9282742 http://www.ncbi.nlm.nih.gov/pubmed/9282742 PubMed 9495771 http://www.ncbi.nlm.nih.gov/pubmed/9495771 PubMed 9603865 http://www.ncbi.nlm.nih.gov/pubmed/9603865 PubMed 9882666 http://www.ncbi.nlm.nih.gov/pubmed/9882666 RefSeq NP_414636 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414636 RefSeq WP_000588474 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000588474 SMART SM00842 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00842 SMR P0ABH0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABH0 STRING 511145.b0094 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0094&targetmode=cogs STRING COG0849 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0849&targetmode=cogs TIGRFAMs TIGR01174 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01174 UniProtKB FTSA_ECOLI http://www.uniprot.org/uniprot/FTSA_ECOLI UniProtKB-AC P0ABH0 http://www.uniprot.org/uniprot/P0ABH0 charge swissprot:FTSA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FTSA_ECOLI eggNOG COG0849 http://eggnogapi.embl.de/nog_data/html/tree/COG0849 eggNOG ENOG4105CIT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CIT epestfind swissprot:FTSA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FTSA_ECOLI garnier swissprot:FTSA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FTSA_ECOLI helixturnhelix swissprot:FTSA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FTSA_ECOLI hmoment swissprot:FTSA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FTSA_ECOLI iep swissprot:FTSA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FTSA_ECOLI inforesidue swissprot:FTSA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FTSA_ECOLI octanol swissprot:FTSA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FTSA_ECOLI pepcoil swissprot:FTSA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FTSA_ECOLI pepdigest swissprot:FTSA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FTSA_ECOLI pepinfo swissprot:FTSA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FTSA_ECOLI pepnet swissprot:FTSA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FTSA_ECOLI pepstats swissprot:FTSA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FTSA_ECOLI pepwheel swissprot:FTSA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FTSA_ECOLI pepwindow swissprot:FTSA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FTSA_ECOLI sigcleave swissprot:FTSA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FTSA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259626 9 # EcoGene EG10657 nlpA # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GOslim_component GO:0005886 plasma membrane # IntAct P04846 8 # InterPro IPR004872 Lipoprotein_NlpA # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00238 D-Methionine transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism NLPA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30429 PTHR30429 # PATRIC 32122811 VBIEscCol129921_3781 # PIR A26286 LPEC28 # PIRSF PIRSF002854 MetQ # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF03180 Lipoprotein_9 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NLPA_ECOLI Lipoprotein 28 # RefSeq NP_418117 NC_000913.3 # RefSeq WP_000779426 NZ_LN832404.1 # SIMILARITY Belongs to the NlpA lipoprotein family. {ECO 0000305}. # SUBCELLULAR LOCATION NLPA_ECOLI Cell inner membrane; Lipid-anchor. # TIGRFAMs TIGR00363 TIGR00363 # eggNOG COG1464 LUCA # eggNOG ENOG4105D01 Bacteria BLAST swissprot:NLPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NLPA_ECOLI BioCyc ECOL316407:JW3635-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3635-MONOMER BioCyc EcoCyc:EG10657-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10657-MONOMER COG COG1464 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1464 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M12163 http://www.ebi.ac.uk/ena/data/view/M12163 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0651 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0651 EcoGene EG10657 http://www.ecogene.org/geneInfo.php?eg_id=EG10657 EnsemblBacteria AAC76684 http://www.ensemblgenomes.org/id/AAC76684 EnsemblBacteria AAC76684 http://www.ensemblgenomes.org/id/AAC76684 EnsemblBacteria BAE77633 http://www.ensemblgenomes.org/id/BAE77633 EnsemblBacteria BAE77633 http://www.ensemblgenomes.org/id/BAE77633 EnsemblBacteria BAE77633 http://www.ensemblgenomes.org/id/BAE77633 EnsemblBacteria b3661 http://www.ensemblgenomes.org/id/b3661 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 948175 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948175 HOGENOM HOG000222926 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000222926&db=HOGENOM6 InParanoid P04846 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P04846 IntAct P04846 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P04846* InterPro IPR004872 http://www.ebi.ac.uk/interpro/entry/IPR004872 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3635 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3635 KEGG_Gene eco:b3661 http://www.genome.jp/dbget-bin/www_bget?eco:b3661 KEGG_Orthology KO:K02073 http://www.genome.jp/dbget-bin/www_bget?KO:K02073 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA MQSYQSP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MQSYQSP PANTHER PTHR30429 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30429 PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:NLPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NLPA_ECOLI PSORT-B swissprot:NLPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NLPA_ECOLI PSORT2 swissprot:NLPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NLPA_ECOLI Pfam PF03180 http://pfam.xfam.org/family/PF03180 Phobius swissprot:NLPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NLPA_ECOLI PhylomeDB P04846 http://phylomedb.org/?seqid=P04846 ProteinModelPortal P04846 http://www.proteinmodelportal.org/query/uniprot/P04846 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3003106 http://www.ncbi.nlm.nih.gov/pubmed/3003106 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418117 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418117 RefSeq WP_000779426 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000779426 SMR P04846 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P04846 STRING 511145.b3661 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3661&targetmode=cogs STRING COG1464 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1464&targetmode=cogs SWISS-2DPAGE P04846 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P04846 TIGRFAMs TIGR00363 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00363 UniProtKB NLPA_ECOLI http://www.uniprot.org/uniprot/NLPA_ECOLI UniProtKB-AC P04846 http://www.uniprot.org/uniprot/P04846 charge swissprot:NLPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NLPA_ECOLI eggNOG COG1464 http://eggnogapi.embl.de/nog_data/html/tree/COG1464 eggNOG ENOG4105D01 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D01 epestfind swissprot:NLPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NLPA_ECOLI garnier swissprot:NLPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NLPA_ECOLI helixturnhelix swissprot:NLPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NLPA_ECOLI hmoment swissprot:NLPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NLPA_ECOLI iep swissprot:NLPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NLPA_ECOLI inforesidue swissprot:NLPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NLPA_ECOLI octanol swissprot:NLPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NLPA_ECOLI pepcoil swissprot:NLPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NLPA_ECOLI pepdigest swissprot:NLPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NLPA_ECOLI pepinfo swissprot:NLPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NLPA_ECOLI pepnet swissprot:NLPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NLPA_ECOLI pepstats swissprot:NLPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NLPA_ECOLI pepwheel swissprot:NLPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NLPA_ECOLI pepwindow swissprot:NLPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NLPA_ECOLI sigcleave swissprot:NLPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NLPA_ECOLI ## Database ID URL or Descriptions # EcoGene EG13597 yahM # Organism YAHM_ECOLI Escherichia coli (strain K12) # PIR G64759 G64759 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAHM_ECOLI Uncharacterized protein YahM # RefSeq NP_414861 NC_000913.3 # RefSeq WP_000290616 NZ_LN832404.1 BLAST swissprot:YAHM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAHM_ECOLI BioCyc ECOL316407:JW5044-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5044-MONOMER BioCyc EcoCyc:G6192-MONOMER http://biocyc.org/getid?id=EcoCyc:G6192-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3366 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3366 EcoGene EG13597 http://www.ecogene.org/geneInfo.php?eg_id=EG13597 EnsemblBacteria AAC73430 http://www.ensemblgenomes.org/id/AAC73430 EnsemblBacteria AAC73430 http://www.ensemblgenomes.org/id/AAC73430 EnsemblBacteria BAE76110 http://www.ensemblgenomes.org/id/BAE76110 EnsemblBacteria BAE76110 http://www.ensemblgenomes.org/id/BAE76110 EnsemblBacteria BAE76110 http://www.ensemblgenomes.org/id/BAE76110 EnsemblBacteria b0327 http://www.ensemblgenomes.org/id/b0327 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 944969 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944969 HOGENOM HOG000009712 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009712&db=HOGENOM6 KEGG_Gene ecj:JW5044 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5044 KEGG_Gene eco:b0327 http://www.genome.jp/dbget-bin/www_bget?eco:b0327 OMA YHRRWSG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YHRRWSG PSORT swissprot:YAHM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAHM_ECOLI PSORT-B swissprot:YAHM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAHM_ECOLI PSORT2 swissprot:YAHM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAHM_ECOLI Phobius swissprot:YAHM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAHM_ECOLI ProteinModelPortal P75692 http://www.proteinmodelportal.org/query/uniprot/P75692 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414861 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414861 RefSeq WP_000290616 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000290616 STRING 511145.b0327 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0327&targetmode=cogs UniProtKB YAHM_ECOLI http://www.uniprot.org/uniprot/YAHM_ECOLI UniProtKB-AC P75692 http://www.uniprot.org/uniprot/P75692 charge swissprot:YAHM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAHM_ECOLI epestfind swissprot:YAHM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAHM_ECOLI garnier swissprot:YAHM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAHM_ECOLI helixturnhelix swissprot:YAHM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAHM_ECOLI hmoment swissprot:YAHM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAHM_ECOLI iep swissprot:YAHM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAHM_ECOLI inforesidue swissprot:YAHM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAHM_ECOLI octanol swissprot:YAHM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAHM_ECOLI pepcoil swissprot:YAHM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAHM_ECOLI pepdigest swissprot:YAHM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAHM_ECOLI pepinfo swissprot:YAHM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAHM_ECOLI pepnet swissprot:YAHM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAHM_ECOLI pepstats swissprot:YAHM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAHM_ECOLI pepwheel swissprot:YAHM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAHM_ECOLI pepwindow swissprot:YAHM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAHM_ECOLI sigcleave swissprot:YAHM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAHM_ECOLI ## Database ID URL or Descriptions # BioGrid 4261372 208 # EcoGene EG12920 yhfY # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:InterPro. # GOslim_process GO:0008150 biological_process # Gene3D 1.10.1790.10 -; 1. # InterPro IPR011608 PRD # Organism YHFY_ECOLI Escherichia coli (strain K12) # PATRIC 32122196 VBIEscCol129921_3475 # PIR A65133 A65133 # PROSITE PS51372 PRD_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHFY_ECOLI Uncharacterized protein YhfY # RefSeq NP_417841 NC_000913.3 # RefSeq WP_001295165 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA58179.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Contains 1 PRD domain. {ECO:0000255|PROSITE- ProRule PRU00704}. # SUPFAM SSF63520 SSF63520 # eggNOG ENOG4105RMW Bacteria # eggNOG ENOG4111VUY LUCA BLAST swissprot:YHFY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHFY_ECOLI BioCyc ECOL316407:JW5696-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5696-MONOMER BioCyc EcoCyc:G7734-MONOMER http://biocyc.org/getid?id=EcoCyc:G7734-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2756 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2756 EcoGene EG12920 http://www.ecogene.org/geneInfo.php?eg_id=EG12920 EnsemblBacteria AAC76407 http://www.ensemblgenomes.org/id/AAC76407 EnsemblBacteria AAC76407 http://www.ensemblgenomes.org/id/AAC76407 EnsemblBacteria BAE77909 http://www.ensemblgenomes.org/id/BAE77909 EnsemblBacteria BAE77909 http://www.ensemblgenomes.org/id/BAE77909 EnsemblBacteria BAE77909 http://www.ensemblgenomes.org/id/BAE77909 EnsemblBacteria b3382 http://www.ensemblgenomes.org/id/b3382 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.10.1790.10 http://www.cathdb.info/version/latest/superfamily/1.10.1790.10 GeneID 947888 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947888 HOGENOM HOG000125486 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125486&db=HOGENOM6 InterPro IPR011608 http://www.ebi.ac.uk/interpro/entry/IPR011608 KEGG_Gene ecj:JW5696 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5696 KEGG_Gene eco:b3382 http://www.genome.jp/dbget-bin/www_bget?eco:b3382 OMA ENIWLIP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ENIWLIP PROSITE PS51372 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51372 PSORT swissprot:YHFY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHFY_ECOLI PSORT-B swissprot:YHFY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHFY_ECOLI PSORT2 swissprot:YHFY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHFY_ECOLI Phobius swissprot:YHFY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHFY_ECOLI ProteinModelPortal P45551 http://www.proteinmodelportal.org/query/uniprot/P45551 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417841 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417841 RefSeq WP_001295165 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295165 STRING 511145.b3382 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3382&targetmode=cogs SUPFAM SSF63520 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63520 UniProtKB YHFY_ECOLI http://www.uniprot.org/uniprot/YHFY_ECOLI UniProtKB-AC P45551 http://www.uniprot.org/uniprot/P45551 charge swissprot:YHFY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHFY_ECOLI eggNOG ENOG4105RMW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105RMW eggNOG ENOG4111VUY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111VUY epestfind swissprot:YHFY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHFY_ECOLI garnier swissprot:YHFY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHFY_ECOLI helixturnhelix swissprot:YHFY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHFY_ECOLI hmoment swissprot:YHFY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHFY_ECOLI iep swissprot:YHFY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHFY_ECOLI inforesidue swissprot:YHFY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHFY_ECOLI octanol swissprot:YHFY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHFY_ECOLI pepcoil swissprot:YHFY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHFY_ECOLI pepdigest swissprot:YHFY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHFY_ECOLI pepinfo swissprot:YHFY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHFY_ECOLI pepnet swissprot:YHFY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHFY_ECOLI pepstats swissprot:YHFY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHFY_ECOLI pepwheel swissprot:YHFY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHFY_ECOLI pepwindow swissprot:YHFY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHFY_ECOLI sigcleave swissprot:YHFY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHFY_ECOLI ## Database ID URL or Descriptions # BioGrid 4262037 10 # EcoGene EG12987 yqgA # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR007563 DUF554 # Organism YQGA_ECOLI Escherichia coli (strain K12) # PATRIC 32121348 VBIEscCol129921_3062 # PIR E65082 E65082 # Pfam PF04474 DUF554 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQGA_ECOLI Uncharacterized protein YqgA # RefSeq NP_417441 NC_000913.3 # RefSeq WP_000234514 NZ_LN832404.1 # SUBCELLULAR LOCATION YQGA_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # TCDB 9.B.120.1 the duf554 (duf554) family # eggNOG COG1811 LUCA # eggNOG ENOG4108UQV Bacteria BLAST swissprot:YQGA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQGA_ECOLI BioCyc ECOL316407:JW2934-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2934-MONOMER BioCyc EcoCyc:G7534-MONOMER http://biocyc.org/getid?id=EcoCyc:G7534-MONOMER COG COG1811 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1811 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2811 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2811 EcoGene EG12987 http://www.ecogene.org/geneInfo.php?eg_id=EG12987 EnsemblBacteria AAC76003 http://www.ensemblgenomes.org/id/AAC76003 EnsemblBacteria AAC76003 http://www.ensemblgenomes.org/id/AAC76003 EnsemblBacteria BAE77029 http://www.ensemblgenomes.org/id/BAE77029 EnsemblBacteria BAE77029 http://www.ensemblgenomes.org/id/BAE77029 EnsemblBacteria BAE77029 http://www.ensemblgenomes.org/id/BAE77029 EnsemblBacteria b2966 http://www.ensemblgenomes.org/id/b2966 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 947462 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947462 HOGENOM HOG000262314 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000262314&db=HOGENOM6 InParanoid Q46831 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46831 InterPro IPR007563 http://www.ebi.ac.uk/interpro/entry/IPR007563 KEGG_Gene ecj:JW2934 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2934 KEGG_Gene eco:b2966 http://www.genome.jp/dbget-bin/www_bget?eco:b2966 KEGG_Orthology KO:K07150 http://www.genome.jp/dbget-bin/www_bget?KO:K07150 OMA GEFCYLE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GEFCYLE PSORT swissprot:YQGA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQGA_ECOLI PSORT-B swissprot:YQGA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQGA_ECOLI PSORT2 swissprot:YQGA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQGA_ECOLI Pfam PF04474 http://pfam.xfam.org/family/PF04474 Phobius swissprot:YQGA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQGA_ECOLI PhylomeDB Q46831 http://phylomedb.org/?seqid=Q46831 ProteinModelPortal Q46831 http://www.proteinmodelportal.org/query/uniprot/Q46831 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417441 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417441 RefSeq WP_000234514 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000234514 STRING 511145.b2966 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2966&targetmode=cogs STRING COG1811 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1811&targetmode=cogs TCDB 9.B.120.1 http://www.tcdb.org/search/result.php?tc=9.B.120.1 UniProtKB YQGA_ECOLI http://www.uniprot.org/uniprot/YQGA_ECOLI UniProtKB-AC Q46831 http://www.uniprot.org/uniprot/Q46831 charge swissprot:YQGA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQGA_ECOLI eggNOG COG1811 http://eggnogapi.embl.de/nog_data/html/tree/COG1811 eggNOG ENOG4108UQV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UQV epestfind swissprot:YQGA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQGA_ECOLI garnier swissprot:YQGA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQGA_ECOLI helixturnhelix swissprot:YQGA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQGA_ECOLI hmoment swissprot:YQGA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQGA_ECOLI iep swissprot:YQGA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQGA_ECOLI inforesidue swissprot:YQGA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQGA_ECOLI octanol swissprot:YQGA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQGA_ECOLI pepcoil swissprot:YQGA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQGA_ECOLI pepdigest swissprot:YQGA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQGA_ECOLI pepinfo swissprot:YQGA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQGA_ECOLI pepnet swissprot:YQGA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQGA_ECOLI pepstats swissprot:YQGA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQGA_ECOLI pepwheel swissprot:YQGA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQGA_ECOLI pepwindow swissprot:YQGA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQGA_ECOLI sigcleave swissprot:YQGA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQGA_ECOLI ## Database ID URL or Descriptions # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0000746 conjugation; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0008150 biological_process # InterPro IPR016385 Conjugal_tfr_repressor_TrbA # Organism TRBA_ECOLI Escherichia coli (strain K12) # PIR A32238 BVECTA # PIRSF PIRSF003269 TrbA # RecName TRBA_ECOLI Protein TrbA # RefSeq NP_061471 NC_002483.1 # RefSeq NP_862937 NC_004998.1 # RefSeq WP_001287913 NZ_CP014273.1 # RefSeq YP_009068332 NC_025139.1 # RefSeq YP_009070597 NC_025175.1 # SUBCELLULAR LOCATION TRBA_ECOLI Cell membrane; Multi-pass membrane protein. BLAST swissprot:TRBA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRBA_ECOLI DIP DIP-28112N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-28112N EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL M20787 http://www.ebi.ac.uk/ena/data/view/M20787 EMBL U01159 http://www.ebi.ac.uk/ena/data/view/U01159 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0000746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000746 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 1263573 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263573 GeneID 1446501 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1446501 GeneID 20491462 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20491462 GeneID 20492665 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20492665 InterPro IPR016385 http://www.ebi.ac.uk/interpro/entry/IPR016385 OMA FRRIFIC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FRRIFIC PSORT swissprot:TRBA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRBA_ECOLI PSORT-B swissprot:TRBA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRBA_ECOLI PSORT2 swissprot:TRBA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRBA_ECOLI Phobius swissprot:TRBA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRBA_ECOLI ProteinModelPortal P18034 http://www.proteinmodelportal.org/query/uniprot/P18034 PubMed 2536655 http://www.ncbi.nlm.nih.gov/pubmed/2536655 PubMed 7915817 http://www.ncbi.nlm.nih.gov/pubmed/7915817 RefSeq NP_061471 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061471 RefSeq NP_862937 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_862937 RefSeq WP_001287913 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001287913 RefSeq YP_009068332 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009068332 RefSeq YP_009070597 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009070597 UniProtKB TRBA_ECOLI http://www.uniprot.org/uniprot/TRBA_ECOLI UniProtKB-AC P18034 http://www.uniprot.org/uniprot/P18034 charge swissprot:TRBA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRBA_ECOLI epestfind swissprot:TRBA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRBA_ECOLI garnier swissprot:TRBA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRBA_ECOLI helixturnhelix swissprot:TRBA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRBA_ECOLI hmoment swissprot:TRBA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRBA_ECOLI iep swissprot:TRBA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRBA_ECOLI inforesidue swissprot:TRBA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRBA_ECOLI octanol swissprot:TRBA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRBA_ECOLI pepcoil swissprot:TRBA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRBA_ECOLI pepdigest swissprot:TRBA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRBA_ECOLI pepinfo swissprot:TRBA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRBA_ECOLI pepnet swissprot:TRBA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRBA_ECOLI pepstats swissprot:TRBA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRBA_ECOLI pepwheel swissprot:TRBA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRBA_ECOLI pepwindow swissprot:TRBA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRBA_ECOLI sigcleave swissprot:TRBA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRBA_ECOLI ## Database ID URL or Descriptions # BioGrid 4263192 18 # EcoGene EG13915 ycjR # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # Gene3D 3.20.20.150 -; 1. # InterPro IPR013022 Xyl_isomerase-like_TIM-brl # Organism YCJR_ECOLI Escherichia coli (strain K12) # PATRIC 32117900 VBIEscCol129921_1370 # PIR E64880 E64880 # Pfam PF01261 AP_endonuc_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCJR_ECOLI Uncharacterized protein YcjR # RefSeq NP_415830 NC_000913.3 # RefSeq WP_000690229 NZ_LN832404.1 # SIMILARITY Belongs to the hyi family. {ECO 0000305}. # SUPFAM SSF51658 SSF51658 # eggNOG COG1082 LUCA # eggNOG ENOG4107TYA Bacteria BLAST swissprot:YCJR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCJR_ECOLI BioCyc ECOL316407:JW5202-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5202-MONOMER BioCyc EcoCyc:G6652-MONOMER http://biocyc.org/getid?id=EcoCyc:G6652-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3674 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3674 EcoGene EG13915 http://www.ecogene.org/geneInfo.php?eg_id=EG13915 EnsemblBacteria AAC74396 http://www.ensemblgenomes.org/id/AAC74396 EnsemblBacteria AAC74396 http://www.ensemblgenomes.org/id/AAC74396 EnsemblBacteria BAE76399 http://www.ensemblgenomes.org/id/BAE76399 EnsemblBacteria BAE76399 http://www.ensemblgenomes.org/id/BAE76399 EnsemblBacteria BAE76399 http://www.ensemblgenomes.org/id/BAE76399 EnsemblBacteria b1314 http://www.ensemblgenomes.org/id/b1314 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 Gene3D 3.20.20.150 http://www.cathdb.info/version/latest/superfamily/3.20.20.150 GeneID 947427 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947427 HOGENOM HOG000089410 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000089410&db=HOGENOM6 InParanoid P76044 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76044 InterPro IPR013022 http://www.ebi.ac.uk/interpro/entry/IPR013022 KEGG_Gene ecj:JW5202 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5202 KEGG_Gene eco:b1314 http://www.genome.jp/dbget-bin/www_bget?eco:b1314 OMA DATRECF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DATRECF PSORT swissprot:YCJR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCJR_ECOLI PSORT-B swissprot:YCJR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCJR_ECOLI PSORT2 swissprot:YCJR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCJR_ECOLI Pfam PF01261 http://pfam.xfam.org/family/PF01261 Phobius swissprot:YCJR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCJR_ECOLI PhylomeDB P76044 http://phylomedb.org/?seqid=P76044 ProteinModelPortal P76044 http://www.proteinmodelportal.org/query/uniprot/P76044 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415830 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415830 RefSeq WP_000690229 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000690229 SMR P76044 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76044 STRING 511145.b1314 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1314&targetmode=cogs SUPFAM SSF51658 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51658 UniProtKB YCJR_ECOLI http://www.uniprot.org/uniprot/YCJR_ECOLI UniProtKB-AC P76044 http://www.uniprot.org/uniprot/P76044 charge swissprot:YCJR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCJR_ECOLI eggNOG COG1082 http://eggnogapi.embl.de/nog_data/html/tree/COG1082 eggNOG ENOG4107TYA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107TYA epestfind swissprot:YCJR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCJR_ECOLI garnier swissprot:YCJR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCJR_ECOLI helixturnhelix swissprot:YCJR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCJR_ECOLI hmoment swissprot:YCJR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCJR_ECOLI iep swissprot:YCJR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCJR_ECOLI inforesidue swissprot:YCJR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCJR_ECOLI octanol swissprot:YCJR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCJR_ECOLI pepcoil swissprot:YCJR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCJR_ECOLI pepdigest swissprot:YCJR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCJR_ECOLI pepinfo swissprot:YCJR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCJR_ECOLI pepnet swissprot:YCJR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCJR_ECOLI pepstats swissprot:YCJR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCJR_ECOLI pepwheel swissprot:YCJR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCJR_ECOLI pepwindow swissprot:YCJR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCJR_ECOLI sigcleave swissprot:YCJR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCJR_ECOLI ## Database ID URL or Descriptions # BioGrid 4261273 5 # CATALYTIC ACTIVITY MTLD_ECOLI D-mannitol 1-phosphate + NAD(+) = D-fructose 6-phosphate + NADH. # EcoGene EG10616 mtlD # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008926 mannitol-1-phosphate 5-dehydrogenase activity; IDA:EcoCyc. # GO_function GO:0050662 coenzyme binding; IEA:InterPro. # GO_process GO:0019592 mannitol catabolic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.1040.10 -; 1. # Gene3D 3.40.50.720 -; 1. # HAMAP MF_00196 Mannitol_dehydrog # IntAct P09424 11 # InterPro IPR000669 Mannitol_DH # InterPro IPR008927 6-PGluconate_DH_C-like # InterPro IPR013118 Mannitol_DH_C # InterPro IPR013131 Mannitol_DH_N # InterPro IPR013328 6PGD_dom_2 # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR023027 Mannitol_DH_CS # InterPro IPR023028 Mannitol_1_phos_5_DH # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00051 Fructose and mannose metabolism # Organism MTLD_ECOLI Escherichia coli (strain K12) # PATRIC 32122683 VBIEscCol129921_3718 # PIR B65160 B65160 # PRINTS PR00084 MTLDHDRGNASE # PROSITE PS00974 MANNITOL_DHGENASE # Pfam PF01232 Mannitol_dh # Pfam PF08125 Mannitol_dh_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MTLD_ECOLI Mannitol-1-phosphate 5-dehydrogenase # RefSeq NP_418057 NC_000913.3 # RefSeq WP_000645439 NZ_LN832404.1 # SIMILARITY Belongs to the mannitol dehydrogenase family. {ECO 0000305}. # SUBUNIT MTLD_ECOLI Monomer. # SUPFAM SSF48179 SSF48179 # SUPFAM SSF51735 SSF51735 # eggNOG COG0246 LUCA # eggNOG ENOG4107SQ3 Bacteria BLAST swissprot:MTLD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MTLD_ECOLI BioCyc ECOL316407:JW3574-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3574-MONOMER BioCyc EcoCyc:MANNPDEHYDROG-MONOMER http://biocyc.org/getid?id=EcoCyc:MANNPDEHYDROG-MONOMER BioCyc MetaCyc:MANNPDEHYDROG-MONOMER http://biocyc.org/getid?id=MetaCyc:MANNPDEHYDROG-MONOMER COG COG0246 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0246 DIP DIP-10268N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10268N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1111/j.1365-2958.1988.tb00045.x http://dx.doi.org/10.1111/j.1365-2958.1988.tb00045.x DOI 10.1111/j.1365-2958.1990.tb02050.x http://dx.doi.org/10.1111/j.1365-2958.1990.tb02050.x DOI 10.1111/j.1365-2958.1996.tb02652.x http://dx.doi.org/10.1111/j.1365-2958.1996.tb02652.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.17 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.17 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U03845 http://www.ebi.ac.uk/ena/data/view/U03845 EMBL X06794 http://www.ebi.ac.uk/ena/data/view/X06794 EMBL X51359 http://www.ebi.ac.uk/ena/data/view/X51359 ENZYME 1.1.1.17 http://enzyme.expasy.org/EC/1.1.1.17 EchoBASE EB0611 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0611 EcoGene EG10616 http://www.ecogene.org/geneInfo.php?eg_id=EG10616 EnsemblBacteria AAC76624 http://www.ensemblgenomes.org/id/AAC76624 EnsemblBacteria AAC76624 http://www.ensemblgenomes.org/id/AAC76624 EnsemblBacteria BAE77693 http://www.ensemblgenomes.org/id/BAE77693 EnsemblBacteria BAE77693 http://www.ensemblgenomes.org/id/BAE77693 EnsemblBacteria BAE77693 http://www.ensemblgenomes.org/id/BAE77693 EnsemblBacteria b3600 http://www.ensemblgenomes.org/id/b3600 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008926 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008926 GO_function GO:0050662 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050662 GO_process GO:0019592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019592 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.1040.10 http://www.cathdb.info/version/latest/superfamily/1.10.1040.10 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 948117 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948117 HAMAP MF_00196 http://hamap.expasy.org/unirule/MF_00196 HOGENOM HOG000271391 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000271391&db=HOGENOM6 InParanoid P09424 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P09424 IntAct P09424 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P09424* IntEnz 1.1.1.17 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.17 InterPro IPR000669 http://www.ebi.ac.uk/interpro/entry/IPR000669 InterPro IPR008927 http://www.ebi.ac.uk/interpro/entry/IPR008927 InterPro IPR013118 http://www.ebi.ac.uk/interpro/entry/IPR013118 InterPro IPR013131 http://www.ebi.ac.uk/interpro/entry/IPR013131 InterPro IPR013328 http://www.ebi.ac.uk/interpro/entry/IPR013328 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR023027 http://www.ebi.ac.uk/interpro/entry/IPR023027 InterPro IPR023028 http://www.ebi.ac.uk/interpro/entry/IPR023028 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3574 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3574 KEGG_Gene eco:b3600 http://www.genome.jp/dbget-bin/www_bget?eco:b3600 KEGG_Orthology KO:K00009 http://www.genome.jp/dbget-bin/www_bget?KO:K00009 KEGG_Pathway ko00051 http://www.genome.jp/kegg-bin/show_pathway?ko00051 KEGG_Reaction rn:R02703 http://www.genome.jp/dbget-bin/www_bget?rn:R02703 MINT MINT-1240338 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1240338 OMA QHHEDPL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QHHEDPL PRINTS PR00084 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00084 PROSITE PS00974 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00974 PSORT swissprot:MTLD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MTLD_ECOLI PSORT-B swissprot:MTLD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MTLD_ECOLI PSORT2 swissprot:MTLD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MTLD_ECOLI Pfam PF01232 http://pfam.xfam.org/family/PF01232 Pfam PF08125 http://pfam.xfam.org/family/PF08125 Phobius swissprot:MTLD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MTLD_ECOLI PhylomeDB P09424 http://phylomedb.org/?seqid=P09424 ProteinModelPortal P09424 http://www.proteinmodelportal.org/query/uniprot/P09424 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 1964486 http://www.ncbi.nlm.nih.gov/pubmed/1964486 PubMed 3135464 http://www.ncbi.nlm.nih.gov/pubmed/3135464 PubMed 6384188 http://www.ncbi.nlm.nih.gov/pubmed/6384188 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 8300537 http://www.ncbi.nlm.nih.gov/pubmed/8300537 PubMed 8899705 http://www.ncbi.nlm.nih.gov/pubmed/8899705 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418057 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418057 RefSeq WP_000645439 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000645439 SMR P09424 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P09424 STRING 511145.b3600 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3600&targetmode=cogs STRING COG0246 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0246&targetmode=cogs SUPFAM SSF48179 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48179 SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB MTLD_ECOLI http://www.uniprot.org/uniprot/MTLD_ECOLI UniProtKB-AC P09424 http://www.uniprot.org/uniprot/P09424 charge swissprot:MTLD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MTLD_ECOLI eggNOG COG0246 http://eggnogapi.embl.de/nog_data/html/tree/COG0246 eggNOG ENOG4107SQ3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107SQ3 epestfind swissprot:MTLD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MTLD_ECOLI garnier swissprot:MTLD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MTLD_ECOLI helixturnhelix swissprot:MTLD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MTLD_ECOLI hmoment swissprot:MTLD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MTLD_ECOLI iep swissprot:MTLD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MTLD_ECOLI inforesidue swissprot:MTLD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MTLD_ECOLI octanol swissprot:MTLD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MTLD_ECOLI pepcoil swissprot:MTLD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MTLD_ECOLI pepdigest swissprot:MTLD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MTLD_ECOLI pepinfo swissprot:MTLD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MTLD_ECOLI pepnet swissprot:MTLD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MTLD_ECOLI pepstats swissprot:MTLD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MTLD_ECOLI pepwheel swissprot:MTLD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MTLD_ECOLI pepwindow swissprot:MTLD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MTLD_ECOLI sigcleave swissprot:MTLD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MTLD_ECOLI ## Database ID URL or Descriptions # AltName Succinyl-CoA synthetase subunit beta {ECO:0000255|HAMAP-Rule MF_00558} # BIOPHYSICOCHEMICAL PROPERTIES SUCC_ECOLI Kinetic parameters KM=70 uM for ATP {ECO 0000269|PubMed 10353839}; KM=394 uM for GTP {ECO 0000269|PubMed 10353839}; Note=kcat is 2684 min(-1) with ATP as substrate and 1471 min(-1) with GTP as substrate. {ECO 0000269|PubMed 10353839}; pH dependence Optimum pH is 7.4. {ECO 0000269|PubMed 8144675}; # BRENDA 6.2.1 2165 # BioGrid 4259946 7 # CATALYTIC ACTIVITY SUCC_ECOLI ATP + succinate + CoA = ADP + phosphate + succinyl-CoA. {ECO 0000255|HAMAP-Rule MF_00558, ECO 0000269|PubMed 10353839}. # COFACTOR SUCC_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_00558, ECO 0000269|PubMed 10625475}; Note=Binds 1 Mg(2+) ion per subunit. {ECO 0000255|HAMAP- Rule MF_00558, ECO 0000269|PubMed 10625475}; # ENZYME REGULATION Exhibits two interesting properties "substrate synergism", in which the enzyme is most active for the catalysis of its partial reactions only when all the substrate-binding sites are occupied, and "catalytic cooperativity" between alternating active sites in the tetramer, whereby the interaction of substrates (particularly ATP) at one site is needed to promote catalysis at the other. # EcoGene EG10981 sucC # FUNCTION SUCC_ECOLI Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. Can use either ATP or GTP, but prefers ATP. It can also function in the other direction for anabolic purposes, and this may be particularly important for providing succinyl-CoA during anaerobic growth when the oxidative route from 2-oxoglutarate is severely repressed. {ECO 0000255|HAMAP-Rule MF_00558, ECO 0000269|PubMed 10353839}. # GO_component GO:0005737 cytoplasm; IDA:UniProtKB. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0009361 succinate-CoA ligase complex (ADP-forming); IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0004775 succinate-CoA ligase (ADP-forming) activity; IMP:EcoliWiki. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0030145 manganese ion binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006099 tricarboxylic acid cycle; IMP:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.30.1490.20 -; 1. # Gene3D 3.30.470.20 -; 1. # Gene3D 3.40.50.261 -; 1. # HAMAP MF_00558 Succ_CoA_beta # INTERACTION SUCC_ECOLI P0AGE9 sucD; NbExp=3; IntAct=EBI-369117, EBI-369078; # IntAct P0A836 8 # InterPro IPR005809 Succ_CoA_synthase_bsu # InterPro IPR005811 CoA_ligase # InterPro IPR011761 ATP-grasp # InterPro IPR013650 ATP-grasp_succ-CoA_synth-type # InterPro IPR013815 ATP_grasp_subdomain_1 # InterPro IPR013816 ATP_grasp_subdomain_2 # InterPro IPR016102 Succinyl-CoA_synth-like # InterPro IPR017866 Succ-CoA_synthase_bsu_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00020 Citrate cycle (TCA cycle) # KEGG_Pathway ko00640 Propanoate metabolism # KEGG_Pathway ko00660 C5-Branched dibasic acid metabolism # KEGG_Pathway ko00720 Carbon fixation pathways in prokaryotes # MISCELLANEOUS SUCC_ECOLI Succinyl-CoA synthetase (SCS) of E.coli catalyzes its reaction via three steps that involve phosphoryl enzyme and enzyme-bound succinyl phosphate as intermediates. # Organism SUCC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11815 PTHR11815 # PATHWAY SUCC_ECOLI Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route) step 1/1. {ECO 0000255|HAMAP-Rule MF_00558, ECO 0000305|PubMed 10353839}. # PATRIC 32116651 VBIEscCol129921_0758 # PDB 1CQI X-ray; 3.30 A; B/E=1-385 # PDB 1CQJ X-ray; 2.90 A; B/E=1-385 # PDB 1JKJ X-ray; 2.35 A; B/E=1-388 # PDB 1JLL X-ray; 2.69 A; B/E=1-388 # PDB 1SCU X-ray; 2.50 A; B/E=1-388 # PDB 2NU6 X-ray; 2.55 A; B/E=1-388 # PDB 2NU7 X-ray; 2.20 A; B/E=1-388 # PDB 2NU8 X-ray; 2.15 A; B/E=1-388 # PDB 2NU9 X-ray; 2.90 A; B/E/G/I=1-388 # PDB 2NUA X-ray; 2.95 A; B/E=1-388 # PDB 2SCU X-ray; 2.30 A; B/E=1-388 # PIR A24090 SYECSB # PIRSF PIRSF001554 SucCS_beta # PROSITE PS01217 SUCCINYL_COA_LIG_3 # PROSITE PS50975 ATP_GRASP # Pfam PF00549 Ligase_CoA # Pfam PF08442 ATP-grasp_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Succinate--CoA ligase [ADP-forming] subunit beta {ECO:0000255|HAMAP-Rule MF_00558} # RefSeq NP_415256 NC_000913.3 # RefSeq WP_001048602 NZ_LN832404.1 # SIMILARITY Belongs to the succinate/malate CoA ligase beta subunit family. {ECO:0000255|HAMAP-Rule MF_00558}. # SIMILARITY Contains 1 ATP-grasp domain. {ECO:0000255|HAMAP- Rule MF_00558}. # SUBUNIT SUCC_ECOLI Heterotetramer of two alpha and two beta subunits. {ECO 0000255|HAMAP-Rule MF_00558, ECO 0000269|PubMed 8144675, ECO 0000269|PubMed 9917402}. # SUPFAM SSF52210 SSF52210 # TIGRFAMs TIGR01016 sucCoAbeta # UniPathway UPA00223 UER00999 # eggNOG COG0045 LUCA # eggNOG ENOG4105CMV Bacteria BLAST swissprot:SUCC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SUCC_ECOLI BioCyc ECOL316407:JW0717-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0717-MONOMER BioCyc EcoCyc:SUCCCOASYN-BETA http://biocyc.org/getid?id=EcoCyc:SUCCCOASYN-BETA BioCyc MetaCyc:SUCCCOASYN-BETA http://biocyc.org/getid?id=MetaCyc:SUCCCOASYN-BETA COG COG0045 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0045 DIP DIP-31852N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31852N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1998.2324 http://dx.doi.org/10.1006/jmbi.1998.2324 DOI 10.1021/bi00343a031 http://dx.doi.org/10.1021/bi00343a031 DOI 10.1021/bi011518y http://dx.doi.org/10.1021/bi011518y DOI 10.1021/bi990527s http://dx.doi.org/10.1021/bi990527s DOI 10.1021/bi991696f http://dx.doi.org/10.1021/bi991696f DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1107/S0907444907029319 http://dx.doi.org/10.1107/S0907444907029319 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.2.1.5 {ECO:0000255|HAMAP-Rule:MF_00558, ECO:0000269|PubMed:10353839} http://www.genome.jp/dbget-bin/www_bget?EC:6.2.1.5 {ECO:0000255|HAMAP-Rule:MF_00558, ECO:0000269|PubMed:10353839} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01619 http://www.ebi.ac.uk/ena/data/view/J01619 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 6.2.1.5 {ECO:0000255|HAMAP-Rule:MF_00558, ECO:0000269|PubMed:10353839} http://enzyme.expasy.org/EC/6.2.1.5 {ECO:0000255|HAMAP-Rule:MF_00558, ECO:0000269|PubMed:10353839} EchoBASE EB0974 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0974 EcoGene EG10981 http://www.ecogene.org/geneInfo.php?eg_id=EG10981 EnsemblBacteria AAC73822 http://www.ensemblgenomes.org/id/AAC73822 EnsemblBacteria AAC73822 http://www.ensemblgenomes.org/id/AAC73822 EnsemblBacteria BAA35394 http://www.ensemblgenomes.org/id/BAA35394 EnsemblBacteria BAA35394 http://www.ensemblgenomes.org/id/BAA35394 EnsemblBacteria BAA35394 http://www.ensemblgenomes.org/id/BAA35394 EnsemblBacteria b0728 http://www.ensemblgenomes.org/id/b0728 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0009361 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009361 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0004775 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004775 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_process GO:0006099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006099 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.30.1490.20 http://www.cathdb.info/version/latest/superfamily/3.30.1490.20 Gene3D 3.30.470.20 http://www.cathdb.info/version/latest/superfamily/3.30.470.20 Gene3D 3.40.50.261 http://www.cathdb.info/version/latest/superfamily/3.40.50.261 GeneID 945312 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945312 HAMAP MF_00558 http://hamap.expasy.org/unirule/MF_00558 HOGENOM HOG000007059 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000007059&db=HOGENOM6 InParanoid P0A836 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A836 IntAct P0A836 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A836* IntEnz 6.2.1.5 {ECO:0000255|HAMAP-Rule:MF_00558, ECO:0000269|PubMed:10353839} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.2.1.5 {ECO:0000255|HAMAP-Rule:MF_00558, ECO:0000269|PubMed:10353839} InterPro IPR005809 http://www.ebi.ac.uk/interpro/entry/IPR005809 InterPro IPR005811 http://www.ebi.ac.uk/interpro/entry/IPR005811 InterPro IPR011761 http://www.ebi.ac.uk/interpro/entry/IPR011761 InterPro IPR013650 http://www.ebi.ac.uk/interpro/entry/IPR013650 InterPro IPR013815 http://www.ebi.ac.uk/interpro/entry/IPR013815 InterPro IPR013816 http://www.ebi.ac.uk/interpro/entry/IPR013816 InterPro IPR016102 http://www.ebi.ac.uk/interpro/entry/IPR016102 InterPro IPR017866 http://www.ebi.ac.uk/interpro/entry/IPR017866 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0717 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0717 KEGG_Gene eco:b0728 http://www.genome.jp/dbget-bin/www_bget?eco:b0728 KEGG_Orthology KO:K01903 http://www.genome.jp/dbget-bin/www_bget?KO:K01903 KEGG_Pathway ko00020 http://www.genome.jp/kegg-bin/show_pathway?ko00020 KEGG_Pathway ko00640 http://www.genome.jp/kegg-bin/show_pathway?ko00640 KEGG_Pathway ko00660 http://www.genome.jp/kegg-bin/show_pathway?ko00660 KEGG_Pathway ko00720 http://www.genome.jp/kegg-bin/show_pathway?ko00720 KEGG_Reaction rn:R00405 http://www.genome.jp/dbget-bin/www_bget?rn:R00405 KEGG_Reaction rn:R02404 http://www.genome.jp/dbget-bin/www_bget?rn:R02404 OMA YIESGCD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YIESGCD PANTHER PTHR11815 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11815 PDB 1CQI http://www.ebi.ac.uk/pdbe-srv/view/entry/1CQI PDB 1CQJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1CQJ PDB 1JKJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1JKJ PDB 1JLL http://www.ebi.ac.uk/pdbe-srv/view/entry/1JLL PDB 1SCU http://www.ebi.ac.uk/pdbe-srv/view/entry/1SCU PDB 2NU6 http://www.ebi.ac.uk/pdbe-srv/view/entry/2NU6 PDB 2NU7 http://www.ebi.ac.uk/pdbe-srv/view/entry/2NU7 PDB 2NU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/2NU8 PDB 2NU9 http://www.ebi.ac.uk/pdbe-srv/view/entry/2NU9 PDB 2NUA http://www.ebi.ac.uk/pdbe-srv/view/entry/2NUA PDB 2SCU http://www.ebi.ac.uk/pdbe-srv/view/entry/2SCU PDBsum 1CQI http://www.ebi.ac.uk/pdbsum/1CQI PDBsum 1CQJ http://www.ebi.ac.uk/pdbsum/1CQJ PDBsum 1JKJ http://www.ebi.ac.uk/pdbsum/1JKJ PDBsum 1JLL http://www.ebi.ac.uk/pdbsum/1JLL PDBsum 1SCU http://www.ebi.ac.uk/pdbsum/1SCU PDBsum 2NU6 http://www.ebi.ac.uk/pdbsum/2NU6 PDBsum 2NU7 http://www.ebi.ac.uk/pdbsum/2NU7 PDBsum 2NU8 http://www.ebi.ac.uk/pdbsum/2NU8 PDBsum 2NU9 http://www.ebi.ac.uk/pdbsum/2NU9 PDBsum 2NUA http://www.ebi.ac.uk/pdbsum/2NUA PDBsum 2SCU http://www.ebi.ac.uk/pdbsum/2SCU PROSITE PS01217 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01217 PROSITE PS50975 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50975 PSORT swissprot:SUCC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SUCC_ECOLI PSORT-B swissprot:SUCC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SUCC_ECOLI PSORT2 swissprot:SUCC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SUCC_ECOLI Pfam PF00549 http://pfam.xfam.org/family/PF00549 Pfam PF08442 http://pfam.xfam.org/family/PF08442 Phobius swissprot:SUCC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SUCC_ECOLI PhylomeDB P0A836 http://phylomedb.org/?seqid=P0A836 ProteinModelPortal P0A836 http://www.proteinmodelportal.org/query/uniprot/P0A836 PubMed 10353839 http://www.ncbi.nlm.nih.gov/pubmed/10353839 PubMed 10625475 http://www.ncbi.nlm.nih.gov/pubmed/10625475 PubMed 11781092 http://www.ncbi.nlm.nih.gov/pubmed/11781092 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17642514 http://www.ncbi.nlm.nih.gov/pubmed/17642514 PubMed 3002435 http://www.ncbi.nlm.nih.gov/pubmed/3002435 PubMed 8144675 http://www.ncbi.nlm.nih.gov/pubmed/8144675 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9917402 http://www.ncbi.nlm.nih.gov/pubmed/9917402 RefSeq NP_415256 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415256 RefSeq WP_001048602 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001048602 SMR P0A836 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A836 STRING 511145.b0728 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0728&targetmode=cogs STRING COG0045 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0045&targetmode=cogs SUPFAM SSF52210 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52210 SWISS-2DPAGE P0A836 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A836 TIGRFAMs TIGR01016 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01016 UniProtKB SUCC_ECOLI http://www.uniprot.org/uniprot/SUCC_ECOLI UniProtKB-AC P0A836 http://www.uniprot.org/uniprot/P0A836 charge swissprot:SUCC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SUCC_ECOLI eggNOG COG0045 http://eggnogapi.embl.de/nog_data/html/tree/COG0045 eggNOG ENOG4105CMV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CMV epestfind swissprot:SUCC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SUCC_ECOLI garnier swissprot:SUCC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SUCC_ECOLI helixturnhelix swissprot:SUCC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SUCC_ECOLI hmoment swissprot:SUCC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SUCC_ECOLI iep swissprot:SUCC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SUCC_ECOLI inforesidue swissprot:SUCC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SUCC_ECOLI octanol swissprot:SUCC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SUCC_ECOLI pepcoil swissprot:SUCC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SUCC_ECOLI pepdigest swissprot:SUCC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SUCC_ECOLI pepinfo swissprot:SUCC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SUCC_ECOLI pepnet swissprot:SUCC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SUCC_ECOLI pepstats swissprot:SUCC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SUCC_ECOLI pepwheel swissprot:SUCC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SUCC_ECOLI pepwindow swissprot:SUCC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SUCC_ECOLI sigcleave swissprot:SUCC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SUCC_ECOLI ## Database ID URL or Descriptions # AltName AAT_ECOLI Transaminase A # BRENDA 2.6.1 2026 # BioGrid 4260021 18 # CATALYTIC ACTIVITY L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate. {ECO:0000269|PubMed 10556573}. # COFACTOR AAT_ECOLI Name=pyridoxal 5'-phosphate; Xref=ChEBI CHEBI 597326; Evidence={ECO 0000269|PubMed 11148029}; # EcoGene EG10096 aspC # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function AAT_ECOLI GO 0004069 L-aspartate 2-oxoglutarate aminotransferase activity; IMP EcoliWiki. # GO_function AAT_ECOLI GO 0004838 L-tyrosine 2-oxoglutarate aminotransferase activity; IMP EcoliWiki. # GO_function AAT_ECOLI GO 0080130 L-phenylalanine 2-oxoglutarate aminotransferase activity; IEA UniProtKB-EC. # GO_function GO:0030170 pyridoxal phosphate binding; IDA:EcoliWiki. # GO_process GO:0009094 L-phenylalanine biosynthetic process; IGI:EcoliWiki. # GO_process GO:0033585 L-phenylalanine biosynthetic process from chorismate via phenylpyruvate; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.640.10 -; 1. # INTERACTION AAT_ECOLI Self; NbExp=4; IntAct=EBI-907474, EBI-907474; # IntAct P00509 4 # InterPro IPR000796 Asp_trans # InterPro IPR004838 NHTrfase_class1_PyrdxlP-BS # InterPro IPR004839 Aminotransferase_I/II # InterPro IPR015421 PyrdxlP-dep_Trfase_major_sub1 # InterPro IPR015424 PyrdxlP-dep_Trfase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01007 Amino acid related enzymes # KEGG_Pathway ko00250 Alanine, aspartate and glutamate metabolism # KEGG_Pathway ko00270 Cysteine and methionine metabolism # KEGG_Pathway ko00330 Arginine and proline metabolism # KEGG_Pathway ko00350 Tyrosine metabolism # KEGG_Pathway ko00360 Phenylalanine metabolism # KEGG_Pathway ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis # KEGG_Pathway ko00401 Novobiocin biosynthesis # KEGG_Pathway ko00950 Isoquinoline alkaloid biosynthesis # KEGG_Pathway ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis # Organism AAT_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11879 PTHR11879 # PATRIC 32117069 VBIEscCol129921_0959 # PDB 1AAM X-ray; 2.80 A; A=1-396 # PDB 1AAW X-ray; 2.40 A; A=1-396 # PDB 1AHE X-ray; 2.30 A; A/B=1-396 # PDB 1AHF X-ray; 2.30 A; A/B=1-396 # PDB 1AHG X-ray; 2.50 A; A/B=1-396 # PDB 1AHX X-ray; 2.00 A; A/B=1-396 # PDB 1AHY X-ray; 2.30 A; A/B=1-396 # PDB 1AIA X-ray; 2.20 A; A/B=1-396 # PDB 1AIB X-ray; 2.80 A; A/B=1-396 # PDB 1AIC X-ray; 2.40 A; A/B=1-396 # PDB 1AMQ X-ray; 2.20 A; A=1-396 # PDB 1AMR X-ray; 2.10 A; A=1-396 # PDB 1AMS X-ray; 2.70 A; A=1-396 # PDB 1ARG X-ray; 2.20 A; A/B=1-396 # PDB 1ARH X-ray; 2.30 A; A/B=1-396 # PDB 1ARI X-ray; 2.30 A; A/B=1-396 # PDB 1ARS X-ray; 1.80 A; A=1-396 # PDB 1ART X-ray; 1.80 A; A=1-396 # PDB 1ASA X-ray; 2.40 A; A=1-396 # PDB 1ASB X-ray; 2.60 A; A=1-396 # PDB 1ASC X-ray; 2.40 A; A=1-396 # PDB 1ASD X-ray; 2.20 A; A=1-396 # PDB 1ASE X-ray; 2.50 A; A=1-396 # PDB 1ASF X-ray; 2.80 A; A=1-396 # PDB 1ASG X-ray; 2.80 A; A=1-396 # PDB 1ASL X-ray; 2.60 A; A/B=1-396 # PDB 1ASM X-ray; 2.35 A; A/B=1-396 # PDB 1ASN X-ray; 2.50 A; A/B=1-396 # PDB 1B4X X-ray; 2.45 A; A=1-396 # PDB 1BQA X-ray; 2.10 A; A/B=1-396 # PDB 1BQD X-ray; 2.10 A; A/B=1-396 # PDB 1C9C X-ray; 2.40 A; A=1-396 # PDB 1CQ6 X-ray; 2.70 A; A=1-396 # PDB 1CQ7 X-ray; 2.40 A; A=1-396 # PDB 1CQ8 X-ray; 2.40 A; A=1-396 # PDB 1CZC X-ray; 2.50 A; A=1-396 # PDB 1CZE X-ray; 2.40 A; A=1-396 # PDB 1G4V X-ray; 2.00 A; A=1-396 # PDB 1G4X X-ray; 2.20 A; A=1-396 # PDB 1G7W X-ray; 2.20 A; A=1-396 # PDB 1G7X X-ray; 2.20 A; A=1-396 # PDB 1IX6 X-ray; 2.20 A; A=1-396 # PDB 1IX7 X-ray; 2.20 A; A=1-396 # PDB 1IX8 X-ray; 2.20 A; A=1-396 # PDB 1QIR X-ray; 2.20 A; A=1-396 # PDB 1QIS X-ray; 1.90 A; A=1-396 # PDB 1QIT X-ray; 1.90 A; A=1-396 # PDB 1SPA X-ray; 2.00 A; A=1-396 # PDB 1TOE X-ray; 2.00 A; A=1-388 # PDB 1TOG X-ray; 2.31 A; A/B=1-388 # PDB 1TOI X-ray; 1.90 A; A=1-388 # PDB 1TOJ X-ray; 1.90 A; A=1-388 # PDB 1TOK X-ray; 1.85 A; A/B=1-388 # PDB 1X28 X-ray; 2.40 A; A/B=1-396 # PDB 1X29 X-ray; 2.20 A; A/B=1-396 # PDB 1X2A X-ray; 2.20 A; A/B=1-396 # PDB 1YOO X-ray; 2.40 A; A=1-396 # PDB 2AAT X-ray; 2.80 A; A=1-396 # PDB 2D5Y X-ray; 1.98 A; A=1-396 # PDB 2D61 X-ray; 2.01 A; A=1-396 # PDB 2D63 X-ray; 2.05 A; A=1-396 # PDB 2D64 X-ray; 2.05 A; A=1-396 # PDB 2D65 X-ray; 2.30 A; A=1-396 # PDB 2D66 X-ray; 2.18 A; A=1-396 # PDB 2D7Y X-ray; 2.66 A; A=1-396 # PDB 2D7Z X-ray; 2.65 A; A=1-396 # PDB 2Q7W X-ray; 1.40 A; A=1-396 # PDB 2QA3 X-ray; 1.75 A; A=1-396 # PDB 2QB2 X-ray; 1.70 A; A=1-396 # PDB 2QB3 X-ray; 1.45 A; A=1-396 # PDB 2QBT X-ray; 1.75 A; A=1-396 # PDB 3AAT X-ray; 2.80 A; A=1-396 # PDB 3QN6 X-ray; 1.79 A; A=1-396 # PDB 3QPG X-ray; 1.79 A; A=1-396 # PDB 3ZZJ X-ray; 2.50 A; A=1-396 # PDB 3ZZK X-ray; 1.78 A; A=1-396 # PDB 4A00 X-ray; 2.34 A; A=1-396 # PDB 4DBC X-ray; 1.50 A; A=1-396 # PDB 4F5F X-ray; 2.25 A; A/B=2-396 # PDB 4F5G X-ray; 1.67 A; A/B=2-396 # PDB 4F5H X-ray; 1.60 A; A/B=2-396 # PDB 4F5I X-ray; 2.20 A; A/B=2-396 # PDB 4F5J X-ray; 1.95 A; A/B=2-396 # PDB 4F5K X-ray; 2.20 A; A/B=2-396 # PDB 4F5L X-ray; 1.40 A; A/B=2-396 # PDB 4F5M X-ray; 1.65 A; A/B=2-396 # PDB 5EAA X-ray; 2.40 A; A=1-396 # PIR A00598 XNECD # PRINTS PR00799 TRANSAMINASE # PROSITE PS00105 AA_TRANSFER_CLASS_1 # Pfam PF00155 Aminotran_1_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AAT_ECOLI Aspartate aminotransferase # RefSeq NP_415448 NC_000913.3 # RefSeq WP_000462687 NZ_LN832404.1 # SIMILARITY Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. {ECO 0000305}. # SUBCELLULAR LOCATION AAT_ECOLI Cytoplasm. # SUBUNIT Homodimer. {ECO:0000269|PubMed 17713924}. # SUPFAM SSF53383 SSF53383 # eggNOG COG1448 LUCA # eggNOG ENOG4105CGF Bacteria BLAST swissprot:AAT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AAT_ECOLI BioCyc ECOL316407:JW0911-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0911-MONOMER BioCyc EcoCyc:ASPAMINOTRANS-MONOMER http://biocyc.org/getid?id=EcoCyc:ASPAMINOTRANS-MONOMER BioCyc MetaCyc:ASPAMINOTRANS-MONOMER http://biocyc.org/getid?id=MetaCyc:ASPAMINOTRANS-MONOMER COG COG1448 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1448 DIP DIP-9181N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9181N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1016/0006-291X(84)90439-X http://dx.doi.org/10.1016/0006-291X(84)90439-X DOI 10.1016/S0167-4838(99)00181-8 http://dx.doi.org/10.1016/S0167-4838(99)00181-8 DOI 10.1021/bi001403e http://dx.doi.org/10.1021/bi001403e DOI 10.1021/bi00221a035 http://dx.doi.org/10.1021/bi00221a035 DOI 10.1021/bi00245a019 http://dx.doi.org/10.1021/bi00245a019 DOI 10.1021/bi00446a030 http://dx.doi.org/10.1021/bi00446a030 DOI 10.1021/bi700663n http://dx.doi.org/10.1021/bi700663n DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2340593 http://dx.doi.org/10.1042/bj2340593 DOI 10.1074/jbc.274.4.2344 http://dx.doi.org/10.1074/jbc.274.4.2344 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.6.1.1 http://www.genome.jp/dbget-bin/www_bget?EC:2.6.1.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X03629 http://www.ebi.ac.uk/ena/data/view/X03629 EMBL X05904 http://www.ebi.ac.uk/ena/data/view/X05904 ENZYME 2.6.1.1 http://enzyme.expasy.org/EC/2.6.1.1 EchoBASE EB0094 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0094 EcoGene EG10096 http://www.ecogene.org/geneInfo.php?eg_id=EG10096 EnsemblBacteria AAC74014 http://www.ensemblgenomes.org/id/AAC74014 EnsemblBacteria AAC74014 http://www.ensemblgenomes.org/id/AAC74014 EnsemblBacteria BAA35674 http://www.ensemblgenomes.org/id/BAA35674 EnsemblBacteria BAA35674 http://www.ensemblgenomes.org/id/BAA35674 EnsemblBacteria BAA35674 http://www.ensemblgenomes.org/id/BAA35674 EnsemblBacteria b0928 http://www.ensemblgenomes.org/id/b0928 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004069 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004069 GO_function GO:0004838 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004838 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_function GO:0080130 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0080130 GO_process GO:0009094 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009094 GO_process GO:0033585 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033585 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.640.10 http://www.cathdb.info/version/latest/superfamily/3.40.640.10 GeneID 945553 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945553 HOGENOM HOG000185899 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000185899&db=HOGENOM6 InParanoid P00509 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00509 IntAct P00509 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00509* IntEnz 2.6.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.6.1.1 InterPro IPR000796 http://www.ebi.ac.uk/interpro/entry/IPR000796 InterPro IPR004838 http://www.ebi.ac.uk/interpro/entry/IPR004838 InterPro IPR004839 http://www.ebi.ac.uk/interpro/entry/IPR004839 InterPro IPR015421 http://www.ebi.ac.uk/interpro/entry/IPR015421 InterPro IPR015424 http://www.ebi.ac.uk/interpro/entry/IPR015424 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Gene ecj:JW0911 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0911 KEGG_Gene eco:b0928 http://www.genome.jp/dbget-bin/www_bget?eco:b0928 KEGG_Orthology KO:K00813 http://www.genome.jp/dbget-bin/www_bget?KO:K00813 KEGG_Pathway ko00250 http://www.genome.jp/kegg-bin/show_pathway?ko00250 KEGG_Pathway ko00270 http://www.genome.jp/kegg-bin/show_pathway?ko00270 KEGG_Pathway ko00330 http://www.genome.jp/kegg-bin/show_pathway?ko00330 KEGG_Pathway ko00350 http://www.genome.jp/kegg-bin/show_pathway?ko00350 KEGG_Pathway ko00360 http://www.genome.jp/kegg-bin/show_pathway?ko00360 KEGG_Pathway ko00400 http://www.genome.jp/kegg-bin/show_pathway?ko00400 KEGG_Pathway ko00401 http://www.genome.jp/kegg-bin/show_pathway?ko00401 KEGG_Pathway ko00950 http://www.genome.jp/kegg-bin/show_pathway?ko00950 KEGG_Pathway ko00960 http://www.genome.jp/kegg-bin/show_pathway?ko00960 KEGG_Reaction rn:R00355 http://www.genome.jp/dbget-bin/www_bget?rn:R00355 KEGG_Reaction rn:R00694 http://www.genome.jp/dbget-bin/www_bget?rn:R00694 KEGG_Reaction rn:R00734 http://www.genome.jp/dbget-bin/www_bget?rn:R00734 KEGG_Reaction rn:R00896 http://www.genome.jp/dbget-bin/www_bget?rn:R00896 KEGG_Reaction rn:R02433 http://www.genome.jp/dbget-bin/www_bget?rn:R02433 KEGG_Reaction rn:R02619 http://www.genome.jp/dbget-bin/www_bget?rn:R02619 KEGG_Reaction rn:R05052 http://www.genome.jp/dbget-bin/www_bget?rn:R05052 OMA PNHKGVF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PNHKGVF PANTHER PTHR11879 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11879 PDB 1AAM http://www.ebi.ac.uk/pdbe-srv/view/entry/1AAM PDB 1AAW http://www.ebi.ac.uk/pdbe-srv/view/entry/1AAW PDB 1AHE http://www.ebi.ac.uk/pdbe-srv/view/entry/1AHE PDB 1AHF http://www.ebi.ac.uk/pdbe-srv/view/entry/1AHF PDB 1AHG http://www.ebi.ac.uk/pdbe-srv/view/entry/1AHG PDB 1AHX http://www.ebi.ac.uk/pdbe-srv/view/entry/1AHX PDB 1AHY http://www.ebi.ac.uk/pdbe-srv/view/entry/1AHY PDB 1AIA http://www.ebi.ac.uk/pdbe-srv/view/entry/1AIA PDB 1AIB http://www.ebi.ac.uk/pdbe-srv/view/entry/1AIB PDB 1AIC http://www.ebi.ac.uk/pdbe-srv/view/entry/1AIC PDB 1AMQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1AMQ PDB 1AMR http://www.ebi.ac.uk/pdbe-srv/view/entry/1AMR PDB 1AMS http://www.ebi.ac.uk/pdbe-srv/view/entry/1AMS PDB 1ARG http://www.ebi.ac.uk/pdbe-srv/view/entry/1ARG PDB 1ARH http://www.ebi.ac.uk/pdbe-srv/view/entry/1ARH PDB 1ARI http://www.ebi.ac.uk/pdbe-srv/view/entry/1ARI PDB 1ARS http://www.ebi.ac.uk/pdbe-srv/view/entry/1ARS PDB 1ART http://www.ebi.ac.uk/pdbe-srv/view/entry/1ART PDB 1ASA http://www.ebi.ac.uk/pdbe-srv/view/entry/1ASA PDB 1ASB http://www.ebi.ac.uk/pdbe-srv/view/entry/1ASB PDB 1ASC http://www.ebi.ac.uk/pdbe-srv/view/entry/1ASC PDB 1ASD http://www.ebi.ac.uk/pdbe-srv/view/entry/1ASD PDB 1ASE http://www.ebi.ac.uk/pdbe-srv/view/entry/1ASE PDB 1ASF http://www.ebi.ac.uk/pdbe-srv/view/entry/1ASF PDB 1ASG http://www.ebi.ac.uk/pdbe-srv/view/entry/1ASG PDB 1ASL http://www.ebi.ac.uk/pdbe-srv/view/entry/1ASL PDB 1ASM http://www.ebi.ac.uk/pdbe-srv/view/entry/1ASM PDB 1ASN http://www.ebi.ac.uk/pdbe-srv/view/entry/1ASN PDB 1B4X http://www.ebi.ac.uk/pdbe-srv/view/entry/1B4X PDB 1BQA http://www.ebi.ac.uk/pdbe-srv/view/entry/1BQA PDB 1BQD http://www.ebi.ac.uk/pdbe-srv/view/entry/1BQD PDB 1C9C http://www.ebi.ac.uk/pdbe-srv/view/entry/1C9C PDB 1CQ6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1CQ6 PDB 1CQ7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1CQ7 PDB 1CQ8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1CQ8 PDB 1CZC http://www.ebi.ac.uk/pdbe-srv/view/entry/1CZC PDB 1CZE http://www.ebi.ac.uk/pdbe-srv/view/entry/1CZE PDB 1G4V http://www.ebi.ac.uk/pdbe-srv/view/entry/1G4V PDB 1G4X http://www.ebi.ac.uk/pdbe-srv/view/entry/1G4X PDB 1G7W http://www.ebi.ac.uk/pdbe-srv/view/entry/1G7W PDB 1G7X http://www.ebi.ac.uk/pdbe-srv/view/entry/1G7X PDB 1IX6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1IX6 PDB 1IX7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1IX7 PDB 1IX8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1IX8 PDB 1QIR http://www.ebi.ac.uk/pdbe-srv/view/entry/1QIR PDB 1QIS http://www.ebi.ac.uk/pdbe-srv/view/entry/1QIS PDB 1QIT http://www.ebi.ac.uk/pdbe-srv/view/entry/1QIT PDB 1SPA http://www.ebi.ac.uk/pdbe-srv/view/entry/1SPA PDB 1TOE http://www.ebi.ac.uk/pdbe-srv/view/entry/1TOE PDB 1TOG http://www.ebi.ac.uk/pdbe-srv/view/entry/1TOG PDB 1TOI http://www.ebi.ac.uk/pdbe-srv/view/entry/1TOI PDB 1TOJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1TOJ PDB 1TOK http://www.ebi.ac.uk/pdbe-srv/view/entry/1TOK PDB 1X28 http://www.ebi.ac.uk/pdbe-srv/view/entry/1X28 PDB 1X29 http://www.ebi.ac.uk/pdbe-srv/view/entry/1X29 PDB 1X2A http://www.ebi.ac.uk/pdbe-srv/view/entry/1X2A PDB 1YOO http://www.ebi.ac.uk/pdbe-srv/view/entry/1YOO PDB 2AAT http://www.ebi.ac.uk/pdbe-srv/view/entry/2AAT PDB 2D5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/2D5Y PDB 2D61 http://www.ebi.ac.uk/pdbe-srv/view/entry/2D61 PDB 2D63 http://www.ebi.ac.uk/pdbe-srv/view/entry/2D63 PDB 2D64 http://www.ebi.ac.uk/pdbe-srv/view/entry/2D64 PDB 2D65 http://www.ebi.ac.uk/pdbe-srv/view/entry/2D65 PDB 2D66 http://www.ebi.ac.uk/pdbe-srv/view/entry/2D66 PDB 2D7Y http://www.ebi.ac.uk/pdbe-srv/view/entry/2D7Y PDB 2D7Z http://www.ebi.ac.uk/pdbe-srv/view/entry/2D7Z PDB 2Q7W http://www.ebi.ac.uk/pdbe-srv/view/entry/2Q7W PDB 2QA3 http://www.ebi.ac.uk/pdbe-srv/view/entry/2QA3 PDB 2QB2 http://www.ebi.ac.uk/pdbe-srv/view/entry/2QB2 PDB 2QB3 http://www.ebi.ac.uk/pdbe-srv/view/entry/2QB3 PDB 2QBT http://www.ebi.ac.uk/pdbe-srv/view/entry/2QBT PDB 3AAT http://www.ebi.ac.uk/pdbe-srv/view/entry/3AAT PDB 3QN6 http://www.ebi.ac.uk/pdbe-srv/view/entry/3QN6 PDB 3QPG http://www.ebi.ac.uk/pdbe-srv/view/entry/3QPG PDB 3ZZJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZZJ PDB 3ZZK http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZZK PDB 4A00 http://www.ebi.ac.uk/pdbe-srv/view/entry/4A00 PDB 4DBC http://www.ebi.ac.uk/pdbe-srv/view/entry/4DBC PDB 4F5F http://www.ebi.ac.uk/pdbe-srv/view/entry/4F5F PDB 4F5G http://www.ebi.ac.uk/pdbe-srv/view/entry/4F5G PDB 4F5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4F5H PDB 4F5I http://www.ebi.ac.uk/pdbe-srv/view/entry/4F5I PDB 4F5J http://www.ebi.ac.uk/pdbe-srv/view/entry/4F5J PDB 4F5K http://www.ebi.ac.uk/pdbe-srv/view/entry/4F5K PDB 4F5L http://www.ebi.ac.uk/pdbe-srv/view/entry/4F5L PDB 4F5M http://www.ebi.ac.uk/pdbe-srv/view/entry/4F5M PDB 5EAA http://www.ebi.ac.uk/pdbe-srv/view/entry/5EAA PDBsum 1AAM http://www.ebi.ac.uk/pdbsum/1AAM PDBsum 1AAW http://www.ebi.ac.uk/pdbsum/1AAW PDBsum 1AHE http://www.ebi.ac.uk/pdbsum/1AHE PDBsum 1AHF http://www.ebi.ac.uk/pdbsum/1AHF PDBsum 1AHG http://www.ebi.ac.uk/pdbsum/1AHG PDBsum 1AHX http://www.ebi.ac.uk/pdbsum/1AHX PDBsum 1AHY http://www.ebi.ac.uk/pdbsum/1AHY PDBsum 1AIA http://www.ebi.ac.uk/pdbsum/1AIA PDBsum 1AIB http://www.ebi.ac.uk/pdbsum/1AIB PDBsum 1AIC http://www.ebi.ac.uk/pdbsum/1AIC PDBsum 1AMQ http://www.ebi.ac.uk/pdbsum/1AMQ PDBsum 1AMR http://www.ebi.ac.uk/pdbsum/1AMR PDBsum 1AMS http://www.ebi.ac.uk/pdbsum/1AMS PDBsum 1ARG http://www.ebi.ac.uk/pdbsum/1ARG PDBsum 1ARH http://www.ebi.ac.uk/pdbsum/1ARH PDBsum 1ARI http://www.ebi.ac.uk/pdbsum/1ARI PDBsum 1ARS http://www.ebi.ac.uk/pdbsum/1ARS PDBsum 1ART http://www.ebi.ac.uk/pdbsum/1ART PDBsum 1ASA http://www.ebi.ac.uk/pdbsum/1ASA PDBsum 1ASB http://www.ebi.ac.uk/pdbsum/1ASB PDBsum 1ASC http://www.ebi.ac.uk/pdbsum/1ASC PDBsum 1ASD http://www.ebi.ac.uk/pdbsum/1ASD PDBsum 1ASE http://www.ebi.ac.uk/pdbsum/1ASE PDBsum 1ASF http://www.ebi.ac.uk/pdbsum/1ASF PDBsum 1ASG http://www.ebi.ac.uk/pdbsum/1ASG PDBsum 1ASL http://www.ebi.ac.uk/pdbsum/1ASL PDBsum 1ASM http://www.ebi.ac.uk/pdbsum/1ASM PDBsum 1ASN http://www.ebi.ac.uk/pdbsum/1ASN PDBsum 1B4X http://www.ebi.ac.uk/pdbsum/1B4X PDBsum 1BQA http://www.ebi.ac.uk/pdbsum/1BQA PDBsum 1BQD http://www.ebi.ac.uk/pdbsum/1BQD PDBsum 1C9C http://www.ebi.ac.uk/pdbsum/1C9C PDBsum 1CQ6 http://www.ebi.ac.uk/pdbsum/1CQ6 PDBsum 1CQ7 http://www.ebi.ac.uk/pdbsum/1CQ7 PDBsum 1CQ8 http://www.ebi.ac.uk/pdbsum/1CQ8 PDBsum 1CZC http://www.ebi.ac.uk/pdbsum/1CZC PDBsum 1CZE http://www.ebi.ac.uk/pdbsum/1CZE PDBsum 1G4V http://www.ebi.ac.uk/pdbsum/1G4V PDBsum 1G4X http://www.ebi.ac.uk/pdbsum/1G4X PDBsum 1G7W http://www.ebi.ac.uk/pdbsum/1G7W PDBsum 1G7X http://www.ebi.ac.uk/pdbsum/1G7X PDBsum 1IX6 http://www.ebi.ac.uk/pdbsum/1IX6 PDBsum 1IX7 http://www.ebi.ac.uk/pdbsum/1IX7 PDBsum 1IX8 http://www.ebi.ac.uk/pdbsum/1IX8 PDBsum 1QIR http://www.ebi.ac.uk/pdbsum/1QIR PDBsum 1QIS http://www.ebi.ac.uk/pdbsum/1QIS PDBsum 1QIT http://www.ebi.ac.uk/pdbsum/1QIT PDBsum 1SPA http://www.ebi.ac.uk/pdbsum/1SPA PDBsum 1TOE http://www.ebi.ac.uk/pdbsum/1TOE PDBsum 1TOG http://www.ebi.ac.uk/pdbsum/1TOG PDBsum 1TOI http://www.ebi.ac.uk/pdbsum/1TOI PDBsum 1TOJ http://www.ebi.ac.uk/pdbsum/1TOJ PDBsum 1TOK http://www.ebi.ac.uk/pdbsum/1TOK PDBsum 1X28 http://www.ebi.ac.uk/pdbsum/1X28 PDBsum 1X29 http://www.ebi.ac.uk/pdbsum/1X29 PDBsum 1X2A http://www.ebi.ac.uk/pdbsum/1X2A PDBsum 1YOO http://www.ebi.ac.uk/pdbsum/1YOO PDBsum 2AAT http://www.ebi.ac.uk/pdbsum/2AAT PDBsum 2D5Y http://www.ebi.ac.uk/pdbsum/2D5Y PDBsum 2D61 http://www.ebi.ac.uk/pdbsum/2D61 PDBsum 2D63 http://www.ebi.ac.uk/pdbsum/2D63 PDBsum 2D64 http://www.ebi.ac.uk/pdbsum/2D64 PDBsum 2D65 http://www.ebi.ac.uk/pdbsum/2D65 PDBsum 2D66 http://www.ebi.ac.uk/pdbsum/2D66 PDBsum 2D7Y http://www.ebi.ac.uk/pdbsum/2D7Y PDBsum 2D7Z http://www.ebi.ac.uk/pdbsum/2D7Z PDBsum 2Q7W http://www.ebi.ac.uk/pdbsum/2Q7W PDBsum 2QA3 http://www.ebi.ac.uk/pdbsum/2QA3 PDBsum 2QB2 http://www.ebi.ac.uk/pdbsum/2QB2 PDBsum 2QB3 http://www.ebi.ac.uk/pdbsum/2QB3 PDBsum 2QBT http://www.ebi.ac.uk/pdbsum/2QBT PDBsum 3AAT http://www.ebi.ac.uk/pdbsum/3AAT PDBsum 3QN6 http://www.ebi.ac.uk/pdbsum/3QN6 PDBsum 3QPG http://www.ebi.ac.uk/pdbsum/3QPG PDBsum 3ZZJ http://www.ebi.ac.uk/pdbsum/3ZZJ PDBsum 3ZZK http://www.ebi.ac.uk/pdbsum/3ZZK PDBsum 4A00 http://www.ebi.ac.uk/pdbsum/4A00 PDBsum 4DBC http://www.ebi.ac.uk/pdbsum/4DBC PDBsum 4F5F http://www.ebi.ac.uk/pdbsum/4F5F PDBsum 4F5G http://www.ebi.ac.uk/pdbsum/4F5G PDBsum 4F5H http://www.ebi.ac.uk/pdbsum/4F5H PDBsum 4F5I http://www.ebi.ac.uk/pdbsum/4F5I PDBsum 4F5J http://www.ebi.ac.uk/pdbsum/4F5J PDBsum 4F5K http://www.ebi.ac.uk/pdbsum/4F5K PDBsum 4F5L http://www.ebi.ac.uk/pdbsum/4F5L PDBsum 4F5M http://www.ebi.ac.uk/pdbsum/4F5M PDBsum 5EAA http://www.ebi.ac.uk/pdbsum/5EAA PRINTS PR00799 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00799 PROSITE PS00105 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00105 PSORT swissprot:AAT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AAT_ECOLI PSORT-B swissprot:AAT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AAT_ECOLI PSORT2 swissprot:AAT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AAT_ECOLI Pfam PF00155 http://pfam.xfam.org/family/PF00155 Phobius swissprot:AAT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AAT_ECOLI PhylomeDB P00509 http://phylomedb.org/?seqid=P00509 ProteinModelPortal P00509 http://www.proteinmodelportal.org/query/uniprot/P00509 PubMed 10556573 http://www.ncbi.nlm.nih.gov/pubmed/10556573 PubMed 11148029 http://www.ncbi.nlm.nih.gov/pubmed/11148029 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17713924 http://www.ncbi.nlm.nih.gov/pubmed/17713924 PubMed 1868057 http://www.ncbi.nlm.nih.gov/pubmed/1868057 PubMed 1993208 http://www.ncbi.nlm.nih.gov/pubmed/1993208 PubMed 2007566 http://www.ncbi.nlm.nih.gov/pubmed/2007566 PubMed 2513875 http://www.ncbi.nlm.nih.gov/pubmed/2513875 PubMed 3298240 http://www.ncbi.nlm.nih.gov/pubmed/3298240 PubMed 3521591 http://www.ncbi.nlm.nih.gov/pubmed/3521591 PubMed 3897210 http://www.ncbi.nlm.nih.gov/pubmed/3897210 PubMed 6378205 http://www.ncbi.nlm.nih.gov/pubmed/6378205 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9891001 http://www.ncbi.nlm.nih.gov/pubmed/9891001 RefSeq NP_415448 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415448 RefSeq WP_000462687 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000462687 SMR P00509 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00509 STRING 511145.b0928 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0928&targetmode=cogs STRING COG1448 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1448&targetmode=cogs SUPFAM SSF53383 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53383 SWISS-2DPAGE P00509 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P00509 UniProtKB AAT_ECOLI http://www.uniprot.org/uniprot/AAT_ECOLI UniProtKB-AC P00509 http://www.uniprot.org/uniprot/P00509 charge swissprot:AAT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AAT_ECOLI eggNOG COG1448 http://eggnogapi.embl.de/nog_data/html/tree/COG1448 eggNOG ENOG4105CGF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CGF epestfind swissprot:AAT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AAT_ECOLI garnier swissprot:AAT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AAT_ECOLI helixturnhelix swissprot:AAT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AAT_ECOLI hmoment swissprot:AAT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AAT_ECOLI iep swissprot:AAT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AAT_ECOLI inforesidue swissprot:AAT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AAT_ECOLI octanol swissprot:AAT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AAT_ECOLI pepcoil swissprot:AAT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AAT_ECOLI pepdigest swissprot:AAT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AAT_ECOLI pepinfo swissprot:AAT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AAT_ECOLI pepnet swissprot:AAT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AAT_ECOLI pepstats swissprot:AAT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AAT_ECOLI pepwheel swissprot:AAT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AAT_ECOLI pepwindow swissprot:AAT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AAT_ECOLI sigcleave swissprot:AAT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AAT_ECOLI ## Database ID URL or Descriptions # BioGrid 4260362 101 # EcoGene EG14030 yobB # GO_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; IEA:InterPro. # GO_process GO:0006807 nitrogen compound metabolic process; IEA:InterPro. # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_process GO:0008150 biological_process # Gene3D 3.60.110.10 -; 1. # IntAct P76280 11 # InterPro IPR003010 C-N_Hydrolase # Organism YOBB_ECOLI Escherichia coli (strain K12) # PATRIC 32119007 VBIEscCol129921_1921 # PIR C64946 C64946 # Pfam PF00795 CN_hydrolase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YOBB_ECOLI Uncharacterized protein YobB # RefSeq NP_416357 NC_000913.3 # RefSeq WP_000011658 NZ_LN832404.1 # SUPFAM SSF56317 SSF56317 # eggNOG COG0388 LUCA # eggNOG ENOG4108YGA Bacteria BLAST swissprot:YOBB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YOBB_ECOLI BioCyc ECOL316407:JW1832-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1832-MONOMER BioCyc EcoCyc:G7015-MONOMER http://biocyc.org/getid?id=EcoCyc:G7015-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3784 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3784 EcoGene EG14030 http://www.ecogene.org/geneInfo.php?eg_id=EG14030 EnsemblBacteria AAC74913 http://www.ensemblgenomes.org/id/AAC74913 EnsemblBacteria AAC74913 http://www.ensemblgenomes.org/id/AAC74913 EnsemblBacteria BAE76546 http://www.ensemblgenomes.org/id/BAE76546 EnsemblBacteria BAE76546 http://www.ensemblgenomes.org/id/BAE76546 EnsemblBacteria BAE76546 http://www.ensemblgenomes.org/id/BAE76546 EnsemblBacteria b1843 http://www.ensemblgenomes.org/id/b1843 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GO_process GO:0006807 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006807 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.60.110.10 http://www.cathdb.info/version/latest/superfamily/3.60.110.10 GeneID 948329 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948329 HOGENOM HOG000267956 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267956&db=HOGENOM6 InParanoid P76280 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76280 IntAct P76280 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76280* InterPro IPR003010 http://www.ebi.ac.uk/interpro/entry/IPR003010 KEGG_Gene ecj:JW1832 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1832 KEGG_Gene eco:b1843 http://www.genome.jp/dbget-bin/www_bget?eco:b1843 OMA LWDETGQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LWDETGQ PSORT swissprot:YOBB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YOBB_ECOLI PSORT-B swissprot:YOBB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YOBB_ECOLI PSORT2 swissprot:YOBB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YOBB_ECOLI Pfam PF00795 http://pfam.xfam.org/family/PF00795 Phobius swissprot:YOBB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YOBB_ECOLI ProteinModelPortal P76280 http://www.proteinmodelportal.org/query/uniprot/P76280 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416357 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416357 RefSeq WP_000011658 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000011658 STRING 511145.b1843 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1843&targetmode=cogs SUPFAM SSF56317 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56317 UniProtKB YOBB_ECOLI http://www.uniprot.org/uniprot/YOBB_ECOLI UniProtKB-AC P76280 http://www.uniprot.org/uniprot/P76280 charge swissprot:YOBB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YOBB_ECOLI eggNOG COG0388 http://eggnogapi.embl.de/nog_data/html/tree/COG0388 eggNOG ENOG4108YGA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108YGA epestfind swissprot:YOBB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YOBB_ECOLI garnier swissprot:YOBB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YOBB_ECOLI helixturnhelix swissprot:YOBB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YOBB_ECOLI hmoment swissprot:YOBB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YOBB_ECOLI iep swissprot:YOBB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YOBB_ECOLI inforesidue swissprot:YOBB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YOBB_ECOLI octanol swissprot:YOBB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YOBB_ECOLI pepcoil swissprot:YOBB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YOBB_ECOLI pepdigest swissprot:YOBB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YOBB_ECOLI pepinfo swissprot:YOBB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YOBB_ECOLI pepnet swissprot:YOBB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YOBB_ECOLI pepstats swissprot:YOBB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YOBB_ECOLI pepwheel swissprot:YOBB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YOBB_ECOLI pepwindow swissprot:YOBB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YOBB_ECOLI sigcleave swissprot:YOBB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YOBB_ECOLI ## Database ID URL or Descriptions # AltName MOTB_ECOLI Chemotaxis protein MotB # BioGrid 4261035 408 # CDD cd07185 OmpA_C-like # EcoGene EG10602 motB # FUNCTION MOTB_ECOLI MotA and MotB comprise the stator element of the flagellar motor complex. Required for the rotation of the flagellar motor. Probably a linker that fastens the torque- generating machinery to the cell wall. Overexpression of this protein with MotA improves motility in a yhjH disruption, (a c-di- GMP phosphodiesterase) suggesting there is an interaction (direct or indirect) between the c-di-GMP-binding flagellar brake protein YcgR and the flagellar stator. {ECO 0000269|PubMed 20346719}. # GO_component GO:0005886 plasma membrane; IDA:EcoliWiki. # GO_component GO:0016021 integral component of membrane; IDA:EcoliWiki. # GO_process GO:0006935 chemotaxis; IEA:UniProtKB-KW. # GO_process GO:0097588 archaeal or bacterial-type flagellum-dependent cell motility; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0040011 locomotion # GOslim_process GO:0048870 cell motility # Gene3D 3.30.1330.60 -; 1. # IntAct P0AF06 4 # InterPro IPR006665 OmpA-like # InterPro IPR025713 MotB_N_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02000 Transporters # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Pathway ko02030 Bacterial chemotaxis # KEGG_Pathway ko02040 Flagellar assembly # Organism MOTB_ECOLI Escherichia coli (strain K12) # PATRIC 32119105 VBIEscCol129921_1970 # PIR A64952 QRECMB # PROSITE PS51123 OMPA_2 # Pfam PF00691 OmpA # Pfam PF13677 MotB_plug # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MOTB_ECOLI Motility protein B # RefSeq NP_416403 NC_000913.3 # RefSeq WP_000795630 NZ_LN832404.1 # SIMILARITY Belongs to the MotB family. {ECO 0000305}. # SIMILARITY Contains 1 OmpA-like domain. {ECO:0000255|PROSITE- ProRule PRU00473}. # SUBCELLULAR LOCATION MOTB_ECOLI Cell inner membrane {ECO 0000269|PubMed 2447650}; Single-pass type II membrane protein {ECO 0000269|PubMed 2447650}. Note=The OmpA-like domain probably functions to anchor the complex to the cell wall. # SUBUNIT MOTB_ECOLI Each stator complex is composed of 4 MotA and 2 MotB subunits; in E.coli 11 to 12 stator complexes can be involved in flagellar rotation. 2 A subunits and 1 B subunit are thought to form a single ion channel, so that each stator complex contains two channels. # SUPFAM SSF103088 SSF103088 # TCDB 1.A.30.1 the h(+)- or na(+)-translocating bacterial flagellar motor/exbbd outer membrane transport energizer (mot/exb) superfamily # eggNOG COG1360 LUCA # eggNOG ENOG4105ER2 Bacteria BLAST swissprot:MOTB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MOTB_ECOLI BioCyc ECOL316407:JW1878-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1878-MONOMER BioCyc EcoCyc:MOTB-FLAGELLAR-MOTOR-STATOR-PROTEIN http://biocyc.org/getid?id=EcoCyc:MOTB-FLAGELLAR-MOTOR-STATOR-PROTEIN COG COG1360 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1360 DIP DIP-47996N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47996N DOI 10.1016/S1937-6448(08)01402-0 http://dx.doi.org/10.1016/S1937-6448(08)01402-0 DOI 10.1016/j.molcel.2010.03.001 http://dx.doi.org/10.1016/j.molcel.2010.03.001 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.2447650 http://dx.doi.org/10.1126/science.2447650 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01652 http://www.ebi.ac.uk/ena/data/view/J01652 EMBL M34669 http://www.ebi.ac.uk/ena/data/view/M34669 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0597 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0597 EcoGene EG10602 http://www.ecogene.org/geneInfo.php?eg_id=EG10602 EnsemblBacteria AAC74959 http://www.ensemblgenomes.org/id/AAC74959 EnsemblBacteria AAC74959 http://www.ensemblgenomes.org/id/AAC74959 EnsemblBacteria BAA15710 http://www.ensemblgenomes.org/id/BAA15710 EnsemblBacteria BAA15710 http://www.ensemblgenomes.org/id/BAA15710 EnsemblBacteria BAA15710 http://www.ensemblgenomes.org/id/BAA15710 EnsemblBacteria b1889 http://www.ensemblgenomes.org/id/b1889 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006935 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006935 GO_process GO:0097588 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097588 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0040011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 Gene3D 3.30.1330.60 http://www.cathdb.info/version/latest/superfamily/3.30.1330.60 GeneID 946402 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946402 HOGENOM HOG000254689 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000254689&db=HOGENOM6 InParanoid P0AF06 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AF06 IntAct P0AF06 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AF06* InterPro IPR006665 http://www.ebi.ac.uk/interpro/entry/IPR006665 InterPro IPR025713 http://www.ebi.ac.uk/interpro/entry/IPR025713 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW1878 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1878 KEGG_Gene eco:b1889 http://www.genome.jp/dbget-bin/www_bget?eco:b1889 KEGG_Orthology KO:K02557 http://www.genome.jp/dbget-bin/www_bget?KO:K02557 KEGG_Pathway ko02030 http://www.genome.jp/kegg-bin/show_pathway?ko02030 KEGG_Pathway ko02040 http://www.genome.jp/kegg-bin/show_pathway?ko02040 OMA TIKAVPN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TIKAVPN PROSITE PS51123 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51123 PSORT swissprot:MOTB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MOTB_ECOLI PSORT-B swissprot:MOTB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MOTB_ECOLI PSORT2 swissprot:MOTB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MOTB_ECOLI Pfam PF00691 http://pfam.xfam.org/family/PF00691 Pfam PF13677 http://pfam.xfam.org/family/PF13677 Phobius swissprot:MOTB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MOTB_ECOLI PhylomeDB P0AF06 http://phylomedb.org/?seqid=P0AF06 ProteinModelPortal P0AF06 http://www.proteinmodelportal.org/query/uniprot/P0AF06 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19081534 http://www.ncbi.nlm.nih.gov/pubmed/19081534 PubMed 2002011 http://www.ncbi.nlm.nih.gov/pubmed/2002011 PubMed 20346719 http://www.ncbi.nlm.nih.gov/pubmed/20346719 PubMed 2061285 http://www.ncbi.nlm.nih.gov/pubmed/2061285 PubMed 2447650 http://www.ncbi.nlm.nih.gov/pubmed/2447650 PubMed 3007435 http://www.ncbi.nlm.nih.gov/pubmed/3007435 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416403 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416403 RefSeq WP_000795630 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000795630 SMR P0AF06 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AF06 STRING 511145.b1889 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1889&targetmode=cogs STRING COG1360 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1360&targetmode=cogs SUPFAM SSF103088 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103088 TCDB 1.A.30.1 http://www.tcdb.org/search/result.php?tc=1.A.30.1 UniProtKB MOTB_ECOLI http://www.uniprot.org/uniprot/MOTB_ECOLI UniProtKB-AC P0AF06 http://www.uniprot.org/uniprot/P0AF06 charge swissprot:MOTB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MOTB_ECOLI eggNOG COG1360 http://eggnogapi.embl.de/nog_data/html/tree/COG1360 eggNOG ENOG4105ER2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ER2 epestfind swissprot:MOTB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MOTB_ECOLI garnier swissprot:MOTB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MOTB_ECOLI helixturnhelix swissprot:MOTB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MOTB_ECOLI hmoment swissprot:MOTB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MOTB_ECOLI iep swissprot:MOTB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MOTB_ECOLI inforesidue swissprot:MOTB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MOTB_ECOLI octanol swissprot:MOTB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MOTB_ECOLI pepcoil swissprot:MOTB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MOTB_ECOLI pepdigest swissprot:MOTB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MOTB_ECOLI pepinfo swissprot:MOTB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MOTB_ECOLI pepnet swissprot:MOTB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MOTB_ECOLI pepstats swissprot:MOTB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MOTB_ECOLI pepwheel swissprot:MOTB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MOTB_ECOLI pepwindow swissprot:MOTB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MOTB_ECOLI sigcleave swissprot:MOTB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MOTB_ECOLI ## Database ID URL or Descriptions # AltName KGUA_ECOLI GMP kinase # BRENDA 2.7.4 2026 # BioGrid 4262568 3 # CATALYTIC ACTIVITY KGUA_ECOLI ATP + GMP = ADP + GDP. # EcoGene EG10965 gmk # FUNCTION KGUA_ECOLI Essential for recycling GMP and indirectly, cGMP. {ECO 0000269|PubMed 8390989}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004385 guanylate kinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.300 -; 3. # HAMAP MF_00328 Guanylate_kinase # IntAct P60546 5 # InterPro IPR008144 Guanylate_kin-like_dom # InterPro IPR008145 GK/Ca_channel_bsu # InterPro IPR017665 Guanylate_kinase # InterPro IPR020590 Guanylate_kinase_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # Organism KGUA_ECOLI Escherichia coli (strain K12) # PATRIC 32122783 VBIEscCol129921_3768 # PDB 1S96 X-ray; 2.00 A; A/B=1-207 # PDB 2AN9 X-ray; 2.35 A; A/B=1-207 # PDB 2ANB X-ray; 2.90 A; A=1-207 # PDB 2ANC X-ray; 3.20 A; A/B/C/D/E/F=1-207 # PDB 2F3R X-ray; 2.50 A; A/B=1-207 # PDB 2F3T X-ray; 3.16 A; A/B/C/D/E/F=1-207 # PIR S43041 KIECGU # PROSITE PS00856 GUANYLATE_KINASE_1 # PROSITE PS50052 GUANYLATE_KINASE_2 # Pfam PF00625 Guanylate_kin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName KGUA_ECOLI Guanylate kinase # RefSeq NP_418105 NC_000913.3 # RefSeq WP_001295237 NZ_LN832404.1 # SIMILARITY Belongs to the guanylate kinase family. {ECO 0000305}. # SIMILARITY Contains 1 guanylate kinase-like domain. {ECO 0000305}. # SMART SM00072 GuKc # SUBCELLULAR LOCATION KGUA_ECOLI Cytoplasm. # SUBUNIT Homotetramer (under low ionic conditions) or homodimer (under high ionic conditions). {ECO:0000269|PubMed 8390989}. # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR03263 guanyl_kin # eggNOG COG0194 LUCA # eggNOG ENOG4108UHA Bacteria BLAST swissprot:KGUA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:KGUA_ECOLI BioCyc ECOL316407:JW3623-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3623-MONOMER BioCyc EcoCyc:GUANYL-KIN-MONOMER http://biocyc.org/getid?id=EcoCyc:GUANYL-KIN-MONOMER BioCyc MetaCyc:GUANYL-KIN-MONOMER http://biocyc.org/getid?id=MetaCyc:GUANYL-KIN-MONOMER COG COG0194 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0194 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.4.8 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.4.8 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M84400 http://www.ebi.ac.uk/ena/data/view/M84400 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.4.8 http://enzyme.expasy.org/EC/2.7.4.8 EchoBASE EB0958 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0958 EcoGene EG10965 http://www.ecogene.org/geneInfo.php?eg_id=EG10965 EnsemblBacteria AAC76672 http://www.ensemblgenomes.org/id/AAC76672 EnsemblBacteria AAC76672 http://www.ensemblgenomes.org/id/AAC76672 EnsemblBacteria BAE77645 http://www.ensemblgenomes.org/id/BAE77645 EnsemblBacteria BAE77645 http://www.ensemblgenomes.org/id/BAE77645 EnsemblBacteria BAE77645 http://www.ensemblgenomes.org/id/BAE77645 EnsemblBacteria b3648 http://www.ensemblgenomes.org/id/b3648 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004385 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004385 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948163 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948163 HAMAP MF_00328 http://hamap.expasy.org/unirule/MF_00328 HOGENOM HOG000037638 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000037638&db=HOGENOM6 InParanoid P60546 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P60546 IntAct P60546 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P60546* IntEnz 2.7.4.8 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.4.8 InterPro IPR008144 http://www.ebi.ac.uk/interpro/entry/IPR008144 InterPro IPR008145 http://www.ebi.ac.uk/interpro/entry/IPR008145 InterPro IPR017665 http://www.ebi.ac.uk/interpro/entry/IPR017665 InterPro IPR020590 http://www.ebi.ac.uk/interpro/entry/IPR020590 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3623 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3623 KEGG_Gene eco:b3648 http://www.genome.jp/dbget-bin/www_bget?eco:b3648 KEGG_Orthology KO:K00942 http://www.genome.jp/dbget-bin/www_bget?KO:K00942 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Reaction rn:R00332 http://www.genome.jp/dbget-bin/www_bget?rn:R00332 KEGG_Reaction rn:R02090 http://www.genome.jp/dbget-bin/www_bget?rn:R02090 MINT MINT-1286577 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1286577 OMA DYCVIND http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DYCVIND PDB 1S96 http://www.ebi.ac.uk/pdbe-srv/view/entry/1S96 PDB 2AN9 http://www.ebi.ac.uk/pdbe-srv/view/entry/2AN9 PDB 2ANB http://www.ebi.ac.uk/pdbe-srv/view/entry/2ANB PDB 2ANC http://www.ebi.ac.uk/pdbe-srv/view/entry/2ANC PDB 2F3R http://www.ebi.ac.uk/pdbe-srv/view/entry/2F3R PDB 2F3T http://www.ebi.ac.uk/pdbe-srv/view/entry/2F3T PDBsum 1S96 http://www.ebi.ac.uk/pdbsum/1S96 PDBsum 2AN9 http://www.ebi.ac.uk/pdbsum/2AN9 PDBsum 2ANB http://www.ebi.ac.uk/pdbsum/2ANB PDBsum 2ANC http://www.ebi.ac.uk/pdbsum/2ANC PDBsum 2F3R http://www.ebi.ac.uk/pdbsum/2F3R PDBsum 2F3T http://www.ebi.ac.uk/pdbsum/2F3T PROSITE PS00856 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00856 PROSITE PS50052 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50052 PSORT swissprot:KGUA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:KGUA_ECOLI PSORT-B swissprot:KGUA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:KGUA_ECOLI PSORT2 swissprot:KGUA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:KGUA_ECOLI Pfam PF00625 http://pfam.xfam.org/family/PF00625 Phobius swissprot:KGUA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:KGUA_ECOLI PhylomeDB P60546 http://phylomedb.org/?seqid=P60546 ProteinModelPortal P60546 http://www.proteinmodelportal.org/query/uniprot/P60546 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 8390989 http://www.ncbi.nlm.nih.gov/pubmed/8390989 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418105 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418105 RefSeq WP_001295237 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295237 SMART SM00072 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00072 SMR P60546 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P60546 STRING 511145.b3648 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3648&targetmode=cogs STRING COG0194 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0194&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR03263 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03263 UniProtKB KGUA_ECOLI http://www.uniprot.org/uniprot/KGUA_ECOLI UniProtKB-AC P60546 http://www.uniprot.org/uniprot/P60546 charge swissprot:KGUA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:KGUA_ECOLI eggNOG COG0194 http://eggnogapi.embl.de/nog_data/html/tree/COG0194 eggNOG ENOG4108UHA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UHA epestfind swissprot:KGUA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:KGUA_ECOLI garnier swissprot:KGUA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:KGUA_ECOLI helixturnhelix swissprot:KGUA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:KGUA_ECOLI hmoment swissprot:KGUA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:KGUA_ECOLI iep swissprot:KGUA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:KGUA_ECOLI inforesidue swissprot:KGUA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:KGUA_ECOLI octanol swissprot:KGUA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:KGUA_ECOLI pepcoil swissprot:KGUA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:KGUA_ECOLI pepdigest swissprot:KGUA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:KGUA_ECOLI pepinfo swissprot:KGUA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:KGUA_ECOLI pepnet swissprot:KGUA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:KGUA_ECOLI pepstats swissprot:KGUA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:KGUA_ECOLI pepwheel swissprot:KGUA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:KGUA_ECOLI pepwindow swissprot:KGUA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:KGUA_ECOLI sigcleave swissprot:KGUA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:KGUA_ECOLI ## Database ID URL or Descriptions # AltName CLCA_ECOLI ClC-ec1 # CAUTION Was originally thought to be a voltage-gated ClC-type chloride channel. {ECO 0000305}. # EcoGene EG12331 clcA # FUNCTION CLCA_ECOLI Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response. {ECO 0000269|PubMed 12384697, ECO 0000269|PubMed 14985752, ECO 0000269|PubMed 16341087, ECO 0000269|PubMed 16905147, ECO 0000269|PubMed 18678918}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_function CLCA_ECOLI GO 0015299 solute proton antiporter activity; IDA EcoCyc. # GO_function GO:0005247 voltage-gated chloride channel activity; IBA:GO_Central. # GO_function GO:0031404 chloride ion binding; IDA:EcoCyc. # GO_function GO:0043168 anion binding; IDA:EcoCyc. # GO_process GO:0006821 chloride transport; IDA:EcoCyc. # GO_process GO:0015706 nitrate transport; IDA:EcoCyc. # GO_process GO:1902476 chloride transmembrane transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # Gene3D 1.10.3080.10 -; 1. # HAMAP MF_01128 CLC_ClcA # INDUCTION CLCA_ECOLI By acid-shock conditions. # InterPro IPR001807 Cl-channel_volt-gated # InterPro IPR014743 Cl-channel_core # InterPro IPR023861 Cl-channel_ClcA # Organism CLCA_ECOLI Escherichia coli (strain K12) # PATRIC 32115419 VBIEscCol129921_0161 # PDB 1KPK X-ray; 3.50 A; A/B/C/D/E/F=1-473 # PDB 1OTS X-ray; 2.51 A; A/B=1-465 # PDB 1OTT X-ray; 3.00 A; A/B=1-465 # PDB 1OTU X-ray; 3.30 A; A/B=1-465 # PDB 2EXW X-ray; 3.20 A; A/B=1-473 # PDB 2EXY X-ray; 3.10 A; A/B=1-473 # PDB 2EZ0 X-ray; 3.54 A; A/B=1-473 # PDB 2FEC X-ray; 3.97 A; A/B=1-465 # PDB 2FED X-ray; 3.32 A; A/B=1-465 # PDB 2FEE X-ray; 3.20 A; A/B=1-465 # PDB 2H2P X-ray; 3.10 A; A/B=1-465 # PDB 2H2S X-ray; 3.10 A; A/B=1-465 # PDB 2HLF X-ray; 3.30 A; A/B=17-460 # PDB 2HT2 X-ray; 3.32 A; A/B=1-473 # PDB 2HT3 X-ray; 3.30 A; A/B=1-473 # PDB 2HT4 X-ray; 3.20 A; A/B=1-473 # PDB 2HTK X-ray; 3.41 A; A/B=1-473 # PDB 2HTL X-ray; 3.40 A; A/B=1-473 # PDB 2R9H X-ray; 3.10 A; A/B=17-460 # PDB 3DET X-ray; 2.80 A; A/B=1-473 # PDB 3EJY X-ray; 3.20 A; A/B=1-473 # PDB 3EJZ X-ray; 2.90 A; A/B=1-473 # PDB 3NMO X-ray; 3.10 A; A=1-465 # PDB 4ENE X-ray; 2.40 A; A/B=17-460 # PDB 4FTP X-ray; 3.21 A; A=1-465 # PDB 4KJP X-ray; 3.20 A; A/B=17-460 # PDB 4KJQ X-ray; 2.88 A; A/B=17-460 # PDB 4KJW X-ray; 3.03 A; A/B=17-460 # PDB 4KK5 X-ray; 3.17 A; A/B=17-460 # PDB 4KK6 X-ray; 3.18 A; A/B=17-460 # PDB 4KK8 X-ray; 2.86 A; A/B=17-460 # PDB 4KK9 X-ray; 3.00 A; A/B=17-460 # PDB 4KKA X-ray; 3.00 A; A/B=17-460 # PDB 4KKB X-ray; 3.02 A; A/B=17-460 # PDB 4KKC X-ray; 3.18 A; A/B=17-460 # PDB 4KKL X-ray; 2.85 A; A/B=17-460 # PDB 4LOU X-ray; 2.98 A; A/B=17-460 # PDB 4MQX X-ray; 3.52 A; A/B=1-465 # PIR C64739 C64739 # PRINTS PR00762 CLCHANNEL # Pfam PF00654 Voltage_CLC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CLCA_ECOLI H(+)/Cl(-) exchange transporter ClcA # RefSeq NP_414697 NC_000913.3 # RefSeq WP_000845394 NZ_LN832404.1 # SIMILARITY Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION CLCA_ECOLI Cell inner membrane {ECO 0000305}; Multi- pass membrane protein {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 18678918}. # SUPFAM SSF81340 SSF81340 # TCDB 2.A.49.5 the chloride carrier/channel (clc) family # eggNOG COG0038 LUCA # eggNOG ENOG4105CMQ Bacteria BLAST swissprot:CLCA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CLCA_ECOLI BioCyc ECOL316407:JW5012-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5012-MONOMER BioCyc EcoCyc:YADQ-MONOMER http://biocyc.org/getid?id=EcoCyc:YADQ-MONOMER BioCyc MetaCyc:YADQ-MONOMER http://biocyc.org/getid?id=MetaCyc:YADQ-MONOMER COG COG0038 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0038 DIP DIP-9523N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9523N DOI 10.1016/S0014-5793(99)01740-8 http://dx.doi.org/10.1016/S0014-5793(99)01740-8 DOI 10.1016/j.jmb.2006.07.006 http://dx.doi.org/10.1016/j.jmb.2006.07.006 DOI 10.1016/j.jmb.2006.07.081 http://dx.doi.org/10.1016/j.jmb.2006.07.081 DOI 10.1038/35051631 http://dx.doi.org/10.1038/35051631 DOI 10.1038/415287a http://dx.doi.org/10.1038/415287a DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature01000 http://dx.doi.org/10.1038/nature01000 DOI 10.1038/nature02314 http://dx.doi.org/10.1038/nature02314 DOI 10.1038/sj.emboj.7600909 http://dx.doi.org/10.1038/sj.emboj.7600909 DOI 10.1073/pnas.0804503105 http://dx.doi.org/10.1073/pnas.0804503105 DOI 10.1085/jgp.114.5.713 http://dx.doi.org/10.1085/jgp.114.5.713 DOI 10.1085/jgp.200810112 http://dx.doi.org/10.1085/jgp.200810112 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1126/science.1082708 http://dx.doi.org/10.1126/science.1082708 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EchoBASE EB2235 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2235 EcoGene EG12331 http://www.ecogene.org/geneInfo.php?eg_id=EG12331 EnsemblBacteria AAC73266 http://www.ensemblgenomes.org/id/AAC73266 EnsemblBacteria AAC73266 http://www.ensemblgenomes.org/id/AAC73266 EnsemblBacteria BAB96732 http://www.ensemblgenomes.org/id/BAB96732 EnsemblBacteria BAB96732 http://www.ensemblgenomes.org/id/BAB96732 EnsemblBacteria BAB96732 http://www.ensemblgenomes.org/id/BAB96732 EnsemblBacteria b0155 http://www.ensemblgenomes.org/id/b0155 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0005247 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005247 GO_function GO:0015299 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015299 GO_function GO:0031404 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031404 GO_function GO:0043168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043168 GO_process GO:0006821 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006821 GO_process GO:0015706 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015706 GO_process GO:1902476 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902476 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 1.10.3080.10 http://www.cathdb.info/version/latest/superfamily/1.10.3080.10 GeneID 946715 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946715 HAMAP MF_01128 http://hamap.expasy.org/unirule/MF_01128 HOGENOM HOG000257546 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000257546&db=HOGENOM6 InParanoid P37019 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37019 InterPro IPR001807 http://www.ebi.ac.uk/interpro/entry/IPR001807 InterPro IPR014743 http://www.ebi.ac.uk/interpro/entry/IPR014743 InterPro IPR023861 http://www.ebi.ac.uk/interpro/entry/IPR023861 KEGG_Gene ecj:JW5012 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5012 KEGG_Gene eco:b0155 http://www.genome.jp/dbget-bin/www_bget?eco:b0155 KEGG_Orthology KO:K03281 http://www.genome.jp/dbget-bin/www_bget?KO:K03281 OMA FPAYHLD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FPAYHLD PDB 1KPK http://www.ebi.ac.uk/pdbe-srv/view/entry/1KPK PDB 1OTS http://www.ebi.ac.uk/pdbe-srv/view/entry/1OTS PDB 1OTT http://www.ebi.ac.uk/pdbe-srv/view/entry/1OTT PDB 1OTU http://www.ebi.ac.uk/pdbe-srv/view/entry/1OTU PDB 2EXW http://www.ebi.ac.uk/pdbe-srv/view/entry/2EXW PDB 2EXY http://www.ebi.ac.uk/pdbe-srv/view/entry/2EXY PDB 2EZ0 http://www.ebi.ac.uk/pdbe-srv/view/entry/2EZ0 PDB 2FEC http://www.ebi.ac.uk/pdbe-srv/view/entry/2FEC PDB 2FED http://www.ebi.ac.uk/pdbe-srv/view/entry/2FED PDB 2FEE http://www.ebi.ac.uk/pdbe-srv/view/entry/2FEE PDB 2H2P http://www.ebi.ac.uk/pdbe-srv/view/entry/2H2P PDB 2H2S http://www.ebi.ac.uk/pdbe-srv/view/entry/2H2S PDB 2HLF http://www.ebi.ac.uk/pdbe-srv/view/entry/2HLF PDB 2HT2 http://www.ebi.ac.uk/pdbe-srv/view/entry/2HT2 PDB 2HT3 http://www.ebi.ac.uk/pdbe-srv/view/entry/2HT3 PDB 2HT4 http://www.ebi.ac.uk/pdbe-srv/view/entry/2HT4 PDB 2HTK http://www.ebi.ac.uk/pdbe-srv/view/entry/2HTK PDB 2HTL http://www.ebi.ac.uk/pdbe-srv/view/entry/2HTL PDB 2R9H http://www.ebi.ac.uk/pdbe-srv/view/entry/2R9H PDB 3DET http://www.ebi.ac.uk/pdbe-srv/view/entry/3DET PDB 3EJY http://www.ebi.ac.uk/pdbe-srv/view/entry/3EJY PDB 3EJZ http://www.ebi.ac.uk/pdbe-srv/view/entry/3EJZ PDB 3NMO http://www.ebi.ac.uk/pdbe-srv/view/entry/3NMO PDB 4ENE http://www.ebi.ac.uk/pdbe-srv/view/entry/4ENE PDB 4FTP http://www.ebi.ac.uk/pdbe-srv/view/entry/4FTP PDB 4KJP http://www.ebi.ac.uk/pdbe-srv/view/entry/4KJP PDB 4KJQ http://www.ebi.ac.uk/pdbe-srv/view/entry/4KJQ PDB 4KJW http://www.ebi.ac.uk/pdbe-srv/view/entry/4KJW PDB 4KK5 http://www.ebi.ac.uk/pdbe-srv/view/entry/4KK5 PDB 4KK6 http://www.ebi.ac.uk/pdbe-srv/view/entry/4KK6 PDB 4KK8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4KK8 PDB 4KK9 http://www.ebi.ac.uk/pdbe-srv/view/entry/4KK9 PDB 4KKA http://www.ebi.ac.uk/pdbe-srv/view/entry/4KKA PDB 4KKB http://www.ebi.ac.uk/pdbe-srv/view/entry/4KKB PDB 4KKC http://www.ebi.ac.uk/pdbe-srv/view/entry/4KKC PDB 4KKL http://www.ebi.ac.uk/pdbe-srv/view/entry/4KKL PDB 4LOU http://www.ebi.ac.uk/pdbe-srv/view/entry/4LOU PDB 4MQX http://www.ebi.ac.uk/pdbe-srv/view/entry/4MQX PDBsum 1KPK http://www.ebi.ac.uk/pdbsum/1KPK PDBsum 1OTS http://www.ebi.ac.uk/pdbsum/1OTS PDBsum 1OTT http://www.ebi.ac.uk/pdbsum/1OTT PDBsum 1OTU http://www.ebi.ac.uk/pdbsum/1OTU PDBsum 2EXW http://www.ebi.ac.uk/pdbsum/2EXW PDBsum 2EXY http://www.ebi.ac.uk/pdbsum/2EXY PDBsum 2EZ0 http://www.ebi.ac.uk/pdbsum/2EZ0 PDBsum 2FEC http://www.ebi.ac.uk/pdbsum/2FEC PDBsum 2FED http://www.ebi.ac.uk/pdbsum/2FED PDBsum 2FEE http://www.ebi.ac.uk/pdbsum/2FEE PDBsum 2H2P http://www.ebi.ac.uk/pdbsum/2H2P PDBsum 2H2S http://www.ebi.ac.uk/pdbsum/2H2S PDBsum 2HLF http://www.ebi.ac.uk/pdbsum/2HLF PDBsum 2HT2 http://www.ebi.ac.uk/pdbsum/2HT2 PDBsum 2HT3 http://www.ebi.ac.uk/pdbsum/2HT3 PDBsum 2HT4 http://www.ebi.ac.uk/pdbsum/2HT4 PDBsum 2HTK http://www.ebi.ac.uk/pdbsum/2HTK PDBsum 2HTL http://www.ebi.ac.uk/pdbsum/2HTL PDBsum 2R9H http://www.ebi.ac.uk/pdbsum/2R9H PDBsum 3DET http://www.ebi.ac.uk/pdbsum/3DET PDBsum 3EJY http://www.ebi.ac.uk/pdbsum/3EJY PDBsum 3EJZ http://www.ebi.ac.uk/pdbsum/3EJZ PDBsum 3NMO http://www.ebi.ac.uk/pdbsum/3NMO PDBsum 4ENE http://www.ebi.ac.uk/pdbsum/4ENE PDBsum 4FTP http://www.ebi.ac.uk/pdbsum/4FTP PDBsum 4KJP http://www.ebi.ac.uk/pdbsum/4KJP PDBsum 4KJQ http://www.ebi.ac.uk/pdbsum/4KJQ PDBsum 4KJW http://www.ebi.ac.uk/pdbsum/4KJW PDBsum 4KK5 http://www.ebi.ac.uk/pdbsum/4KK5 PDBsum 4KK6 http://www.ebi.ac.uk/pdbsum/4KK6 PDBsum 4KK8 http://www.ebi.ac.uk/pdbsum/4KK8 PDBsum 4KK9 http://www.ebi.ac.uk/pdbsum/4KK9 PDBsum 4KKA http://www.ebi.ac.uk/pdbsum/4KKA PDBsum 4KKB http://www.ebi.ac.uk/pdbsum/4KKB PDBsum 4KKC http://www.ebi.ac.uk/pdbsum/4KKC PDBsum 4KKL http://www.ebi.ac.uk/pdbsum/4KKL PDBsum 4LOU http://www.ebi.ac.uk/pdbsum/4LOU PDBsum 4MQX http://www.ebi.ac.uk/pdbsum/4MQX PRINTS PR00762 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00762 PSORT swissprot:CLCA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CLCA_ECOLI PSORT-B swissprot:CLCA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CLCA_ECOLI PSORT2 swissprot:CLCA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CLCA_ECOLI Pfam PF00654 http://pfam.xfam.org/family/PF00654 Phobius swissprot:CLCA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CLCA_ECOLI PhylomeDB P37019 http://phylomedb.org/?seqid=P37019 ProteinModelPortal P37019 http://www.proteinmodelportal.org/query/uniprot/P37019 PubMed 10539975 http://www.ncbi.nlm.nih.gov/pubmed/10539975 PubMed 10648805 http://www.ncbi.nlm.nih.gov/pubmed/10648805 PubMed 11196649 http://www.ncbi.nlm.nih.gov/pubmed/11196649 PubMed 11796999 http://www.ncbi.nlm.nih.gov/pubmed/11796999 PubMed 12384697 http://www.ncbi.nlm.nih.gov/pubmed/12384697 PubMed 12649487 http://www.ncbi.nlm.nih.gov/pubmed/12649487 PubMed 14985752 http://www.ncbi.nlm.nih.gov/pubmed/14985752 PubMed 16341087 http://www.ncbi.nlm.nih.gov/pubmed/16341087 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16905147 http://www.ncbi.nlm.nih.gov/pubmed/16905147 PubMed 16949616 http://www.ncbi.nlm.nih.gov/pubmed/16949616 PubMed 18678918 http://www.ncbi.nlm.nih.gov/pubmed/18678918 PubMed 19139174 http://www.ncbi.nlm.nih.gov/pubmed/19139174 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414697 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414697 RefSeq WP_000845394 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000845394 SMR P37019 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37019 STRING 511145.b0155 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0155&targetmode=cogs STRING COG0038 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0038&targetmode=cogs SUPFAM SSF81340 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81340 TCDB 2.A.49.5 http://www.tcdb.org/search/result.php?tc=2.A.49.5 UniProtKB CLCA_ECOLI http://www.uniprot.org/uniprot/CLCA_ECOLI UniProtKB-AC P37019 http://www.uniprot.org/uniprot/P37019 charge swissprot:CLCA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CLCA_ECOLI eggNOG COG0038 http://eggnogapi.embl.de/nog_data/html/tree/COG0038 eggNOG ENOG4105CMQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CMQ epestfind swissprot:CLCA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CLCA_ECOLI garnier swissprot:CLCA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CLCA_ECOLI helixturnhelix swissprot:CLCA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CLCA_ECOLI hmoment swissprot:CLCA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CLCA_ECOLI iep swissprot:CLCA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CLCA_ECOLI inforesidue swissprot:CLCA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CLCA_ECOLI octanol swissprot:CLCA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CLCA_ECOLI pepcoil swissprot:CLCA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CLCA_ECOLI pepdigest swissprot:CLCA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CLCA_ECOLI pepinfo swissprot:CLCA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CLCA_ECOLI pepnet swissprot:CLCA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CLCA_ECOLI pepstats swissprot:CLCA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CLCA_ECOLI pepwheel swissprot:CLCA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CLCA_ECOLI pepwindow swissprot:CLCA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CLCA_ECOLI sigcleave swissprot:CLCA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CLCA_ECOLI ## Database ID URL or Descriptions # EcoGene EG14464 ythA # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # INDUCTION YTHA_ECOLI Constitutively expressed, induced at 45 degrees Celsius (at protein level). {ECO 0000269|PubMed 19121005, ECO 0000269|PubMed 19734316}. # Organism YTHA_ECOLI Escherichia coli (strain K12) # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YTHA_ECOLI Uncharacterized protein YthA # RefSeq YP_001491548 NC_000913.3 # SUBCELLULAR LOCATION YTHA_ECOLI Cell inner membrane {ECO 0000305}; Single- pass membrane protein {ECO 0000305}. BLAST swissprot:YTHA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YTHA_ECOLI BioCyc EcoCyc:MONOMER0-2840 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2840 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2008.06495.x http://dx.doi.org/10.1111/j.1365-2958.2008.06495.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00872-09 http://dx.doi.org/10.1128/JB.00872-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14464 http://www.ecogene.org/geneInfo.php?eg_id=EG14464 EnsemblBacteria ABV59575 http://www.ensemblgenomes.org/id/ABV59575 EnsemblBacteria ABV59575 http://www.ensemblgenomes.org/id/ABV59575 EnsemblBacteria b4655 http://www.ensemblgenomes.org/id/b4655 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 5625581 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5625581 KEGG_Gene eco:b4655 http://www.genome.jp/dbget-bin/www_bget?eco:b4655 PSORT swissprot:YTHA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YTHA_ECOLI PSORT-B swissprot:YTHA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YTHA_ECOLI PSORT2 swissprot:YTHA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YTHA_ECOLI Phobius swissprot:YTHA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YTHA_ECOLI PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19121005 http://www.ncbi.nlm.nih.gov/pubmed/19121005 PubMed 19734316 http://www.ncbi.nlm.nih.gov/pubmed/19734316 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq YP_001491548 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001491548 STRING 511145.b4655 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4655&targetmode=cogs UniProtKB YTHA_ECOLI http://www.uniprot.org/uniprot/YTHA_ECOLI UniProtKB-AC A8DYQ1 http://www.uniprot.org/uniprot/A8DYQ1 charge swissprot:YTHA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YTHA_ECOLI epestfind swissprot:YTHA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YTHA_ECOLI garnier swissprot:YTHA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YTHA_ECOLI helixturnhelix swissprot:YTHA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YTHA_ECOLI hmoment swissprot:YTHA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YTHA_ECOLI iep swissprot:YTHA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YTHA_ECOLI inforesidue swissprot:YTHA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YTHA_ECOLI octanol swissprot:YTHA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YTHA_ECOLI pepcoil swissprot:YTHA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YTHA_ECOLI pepdigest swissprot:YTHA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YTHA_ECOLI pepinfo swissprot:YTHA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YTHA_ECOLI pepnet swissprot:YTHA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YTHA_ECOLI pepstats swissprot:YTHA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YTHA_ECOLI pepwheel swissprot:YTHA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YTHA_ECOLI pepwindow swissprot:YTHA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YTHA_ECOLI sigcleave swissprot:YTHA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YTHA_ECOLI ## Database ID URL or Descriptions # BioGrid 4263369 11 # EcoGene EG12831 yhdT # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # INDUCTION Down-regulated by cystine. {ECO:0000269|PubMed 25346166}. # InterPro IPR010398 DUF997 # Organism YHDT_ECOLI Escherichia coli (strain K12) # PATRIC 32121944 VBIEscCol129921_3356 # PIR C65118 C65118 # Pfam PF06196 DUF997 # ProDom PD745092 DUF997 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Uncharacterized membrane protein YhdT {ECO 0000305} # RefSeq NP_417723 NC_000913.3 # RefSeq WP_000381173 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=M30953; Type=Frameshift; Positions=38; Evidence={ECO 0000305}; # SIMILARITY To H.influenzae HI_0974B. {ECO 0000305}. # SUBCELLULAR LOCATION YHDT_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000255}. # eggNOG COG3924 LUCA # eggNOG ENOG4105RG0 Bacteria BLAST swissprot:YHDT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHDT_ECOLI BioCyc ECOL316407:JW3225-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3225-MONOMER BioCyc EcoCyc:G7693-MONOMER http://biocyc.org/getid?id=EcoCyc:G7693-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1080/09168451.2014.972328 http://dx.doi.org/10.1080/09168451.2014.972328 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M30953 http://www.ebi.ac.uk/ena/data/view/M30953 EMBL M83198 http://www.ebi.ac.uk/ena/data/view/M83198 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2680 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2680 EcoGene EG12831 http://www.ecogene.org/geneInfo.php?eg_id=EG12831 EnsemblBacteria AAC76289 http://www.ensemblgenomes.org/id/AAC76289 EnsemblBacteria AAC76289 http://www.ensemblgenomes.org/id/AAC76289 EnsemblBacteria BAE77298 http://www.ensemblgenomes.org/id/BAE77298 EnsemblBacteria BAE77298 http://www.ensemblgenomes.org/id/BAE77298 EnsemblBacteria BAE77298 http://www.ensemblgenomes.org/id/BAE77298 EnsemblBacteria b3257 http://www.ensemblgenomes.org/id/b3257 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 947762 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947762 HOGENOM HOG000281947 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000281947&db=HOGENOM6 InterPro IPR010398 http://www.ebi.ac.uk/interpro/entry/IPR010398 KEGG_Gene ecj:JW3225 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3225 KEGG_Gene eco:b3257 http://www.genome.jp/dbget-bin/www_bget?eco:b3257 OMA WFELACL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WFELACL PSORT swissprot:YHDT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHDT_ECOLI PSORT-B swissprot:YHDT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHDT_ECOLI PSORT2 swissprot:YHDT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHDT_ECOLI Pfam PF06196 http://pfam.xfam.org/family/PF06196 Phobius swissprot:YHDT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHDT_ECOLI ProteinModelPortal P45566 http://www.proteinmodelportal.org/query/uniprot/P45566 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2193919 http://www.ncbi.nlm.nih.gov/pubmed/2193919 PubMed 25346166 http://www.ncbi.nlm.nih.gov/pubmed/25346166 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417723 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417723 RefSeq WP_000381173 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000381173 STRING 511145.b3257 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3257&targetmode=cogs UniProtKB YHDT_ECOLI http://www.uniprot.org/uniprot/YHDT_ECOLI UniProtKB-AC P45566 http://www.uniprot.org/uniprot/P45566 charge swissprot:YHDT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHDT_ECOLI eggNOG COG3924 http://eggnogapi.embl.de/nog_data/html/tree/COG3924 eggNOG ENOG4105RG0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105RG0 epestfind swissprot:YHDT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHDT_ECOLI garnier swissprot:YHDT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHDT_ECOLI helixturnhelix swissprot:YHDT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHDT_ECOLI hmoment swissprot:YHDT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHDT_ECOLI iep swissprot:YHDT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHDT_ECOLI inforesidue swissprot:YHDT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHDT_ECOLI octanol swissprot:YHDT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHDT_ECOLI pepcoil swissprot:YHDT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHDT_ECOLI pepdigest swissprot:YHDT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHDT_ECOLI pepinfo swissprot:YHDT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHDT_ECOLI pepnet swissprot:YHDT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHDT_ECOLI pepstats swissprot:YHDT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHDT_ECOLI pepwheel swissprot:YHDT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHDT_ECOLI pepwindow swissprot:YHDT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHDT_ECOLI sigcleave swissprot:YHDT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHDT_ECOLI ## Database ID URL or Descriptions # BioGrid 4263098 3 # EcoGene EG13867 ycdU # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # Organism YCDU_ECOLI Escherichia coli (strain K12) # PATRIC 32117291 VBIEscCol129921_1069 # PIR C64845 C64845 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCDU_ECOLI Uncharacterized protein YcdU # RefSeq NP_415548 NC_000913.3 # RefSeq WP_000611859 NZ_LN832404.1 # SUBCELLULAR LOCATION YCDU_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # eggNOG ENOG4108T85 Bacteria # eggNOG ENOG4111FYW LUCA BLAST swissprot:YCDU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCDU_ECOLI BioCyc ECOL316407:JW1015-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1015-MONOMER BioCyc EcoCyc:G6536-MONOMER http://biocyc.org/getid?id=EcoCyc:G6536-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3627 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3627 EcoGene EG13867 http://www.ecogene.org/geneInfo.php?eg_id=EG13867 EnsemblBacteria AAC74114 http://www.ensemblgenomes.org/id/AAC74114 EnsemblBacteria AAC74114 http://www.ensemblgenomes.org/id/AAC74114 EnsemblBacteria BAA35813 http://www.ensemblgenomes.org/id/BAA35813 EnsemblBacteria BAA35813 http://www.ensemblgenomes.org/id/BAA35813 EnsemblBacteria BAA35813 http://www.ensemblgenomes.org/id/BAA35813 EnsemblBacteria b1029 http://www.ensemblgenomes.org/id/b1029 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 945592 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945592 HOGENOM HOG000009409 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009409&db=HOGENOM6 KEGG_Gene ecj:JW1015 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1015 KEGG_Gene eco:b1029 http://www.genome.jp/dbget-bin/www_bget?eco:b1029 OMA WKNAGFI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WKNAGFI PSORT swissprot:YCDU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCDU_ECOLI PSORT-B swissprot:YCDU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCDU_ECOLI PSORT2 swissprot:YCDU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCDU_ECOLI Phobius swissprot:YCDU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCDU_ECOLI ProteinModelPortal P75910 http://www.proteinmodelportal.org/query/uniprot/P75910 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415548 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415548 RefSeq WP_000611859 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000611859 STRING 511145.b1029 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1029&targetmode=cogs UniProtKB YCDU_ECOLI http://www.uniprot.org/uniprot/YCDU_ECOLI UniProtKB-AC P75910 http://www.uniprot.org/uniprot/P75910 charge swissprot:YCDU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCDU_ECOLI eggNOG ENOG4108T85 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108T85 eggNOG ENOG4111FYW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111FYW epestfind swissprot:YCDU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCDU_ECOLI garnier swissprot:YCDU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCDU_ECOLI helixturnhelix swissprot:YCDU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCDU_ECOLI hmoment swissprot:YCDU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCDU_ECOLI iep swissprot:YCDU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCDU_ECOLI inforesidue swissprot:YCDU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCDU_ECOLI octanol swissprot:YCDU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCDU_ECOLI pepcoil swissprot:YCDU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCDU_ECOLI pepdigest swissprot:YCDU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCDU_ECOLI pepinfo swissprot:YCDU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCDU_ECOLI pepnet swissprot:YCDU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCDU_ECOLI pepstats swissprot:YCDU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCDU_ECOLI pepwheel swissprot:YCDU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCDU_ECOLI pepwindow swissprot:YCDU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCDU_ECOLI sigcleave swissprot:YCDU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCDU_ECOLI ## Database ID URL or Descriptions # BioGrid 4260548 11 # EcoGene EG14139 yfdQ # IntAct P76513 4 # InterPro IPR019276 DUF2303 # Organism YFDQ_ECOLI Escherichia coli (strain K12) # PATRIC 32120097 VBIEscCol129921_2457 # PIR E65009 E65009 # Pfam PF10065 DUF2303 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFDQ_ECOLI Uncharacterized protein YfdQ # RefSeq NP_416861 NC_000913.3 # RefSeq WP_000081278 NZ_LN832404.1 # eggNOG COG5532 LUCA # eggNOG ENOG4108HJ1 Bacteria BLAST swissprot:YFDQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFDQ_ECOLI BioCyc ECOL316407:JW2357-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2357-MONOMER BioCyc EcoCyc:G7229-MONOMER http://biocyc.org/getid?id=EcoCyc:G7229-MONOMER DIP DIP-12005N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12005N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3891 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3891 EcoGene EG14139 http://www.ecogene.org/geneInfo.php?eg_id=EG14139 EnsemblBacteria AAC75419 http://www.ensemblgenomes.org/id/AAC75419 EnsemblBacteria AAC75419 http://www.ensemblgenomes.org/id/AAC75419 EnsemblBacteria BAE76699 http://www.ensemblgenomes.org/id/BAE76699 EnsemblBacteria BAE76699 http://www.ensemblgenomes.org/id/BAE76699 EnsemblBacteria BAE76699 http://www.ensemblgenomes.org/id/BAE76699 EnsemblBacteria b2360 http://www.ensemblgenomes.org/id/b2360 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946827 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946827 HOGENOM HOG000123925 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000123925&db=HOGENOM6 IntAct P76513 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76513* InterPro IPR019276 http://www.ebi.ac.uk/interpro/entry/IPR019276 KEGG_Gene ecj:JW2357 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2357 KEGG_Gene eco:b2360 http://www.genome.jp/dbget-bin/www_bget?eco:b2360 OMA GNTMQIS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GNTMQIS PSORT swissprot:YFDQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFDQ_ECOLI PSORT-B swissprot:YFDQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFDQ_ECOLI PSORT2 swissprot:YFDQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFDQ_ECOLI Pfam PF10065 http://pfam.xfam.org/family/PF10065 Phobius swissprot:YFDQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFDQ_ECOLI ProteinModelPortal P76513 http://www.proteinmodelportal.org/query/uniprot/P76513 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416861 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416861 RefSeq WP_000081278 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000081278 STRING 511145.b2360 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2360&targetmode=cogs UniProtKB YFDQ_ECOLI http://www.uniprot.org/uniprot/YFDQ_ECOLI UniProtKB-AC P76513 http://www.uniprot.org/uniprot/P76513 charge swissprot:YFDQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFDQ_ECOLI eggNOG COG5532 http://eggnogapi.embl.de/nog_data/html/tree/COG5532 eggNOG ENOG4108HJ1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108HJ1 epestfind swissprot:YFDQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFDQ_ECOLI garnier swissprot:YFDQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFDQ_ECOLI helixturnhelix swissprot:YFDQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFDQ_ECOLI hmoment swissprot:YFDQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFDQ_ECOLI iep swissprot:YFDQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFDQ_ECOLI inforesidue swissprot:YFDQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFDQ_ECOLI octanol swissprot:YFDQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFDQ_ECOLI pepcoil swissprot:YFDQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFDQ_ECOLI pepdigest swissprot:YFDQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFDQ_ECOLI pepinfo swissprot:YFDQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFDQ_ECOLI pepnet swissprot:YFDQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFDQ_ECOLI pepstats swissprot:YFDQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFDQ_ECOLI pepwheel swissprot:YFDQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFDQ_ECOLI pepwindow swissprot:YFDQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFDQ_ECOLI sigcleave swissprot:YFDQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFDQ_ECOLI ## Database ID URL or Descriptions # EcoGene EG12865 ydcH # InterPro IPR007420 DUF465 # Organism YDCH_ECOLI Escherichia coli (strain K12) # PATRIC 32118136 VBIEscCol129921_1488 # PIR E64894 E64894 # Pfam PF04325 DUF465 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDCH_ECOLI Uncharacterized protein YdcH # RefSeq NP_415943 NC_000913.3 # RefSeq WP_001296778 NZ_LN832404.1 # eggNOG COG2841 LUCA # eggNOG ENOG4105Z2P Bacteria BLAST swissprot:YDCH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDCH_ECOLI BioCyc ECOL316407:JW5823-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5823-MONOMER BioCyc EcoCyc:EG12865-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12865-MONOMER COG COG2841 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2841 DOI 10.1007/BF02464895 http://dx.doi.org/10.1007/BF02464895 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X15860 http://www.ebi.ac.uk/ena/data/view/X15860 EchoBASE EB2706 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2706 EcoGene EG12865 http://www.ecogene.org/geneInfo.php?eg_id=EG12865 EnsemblBacteria AAC74508 http://www.ensemblgenomes.org/id/AAC74508 EnsemblBacteria AAC74508 http://www.ensemblgenomes.org/id/AAC74508 EnsemblBacteria BAA15047 http://www.ensemblgenomes.org/id/BAA15047 EnsemblBacteria BAA15047 http://www.ensemblgenomes.org/id/BAA15047 EnsemblBacteria BAA15047 http://www.ensemblgenomes.org/id/BAA15047 EnsemblBacteria b1426 http://www.ensemblgenomes.org/id/b1426 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945997 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945997 HOGENOM HOG000275055 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275055&db=HOGENOM6 InterPro IPR007420 http://www.ebi.ac.uk/interpro/entry/IPR007420 KEGG_Gene ecj:JW5823 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5823 KEGG_Gene eco:b1426 http://www.genome.jp/dbget-bin/www_bget?eco:b1426 KEGG_Orthology KO:K09794 http://www.genome.jp/dbget-bin/www_bget?KO:K09794 OMA IKDEMQR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IKDEMQR PSORT swissprot:YDCH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDCH_ECOLI PSORT-B swissprot:YDCH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDCH_ECOLI PSORT2 swissprot:YDCH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDCH_ECOLI Pfam PF04325 http://pfam.xfam.org/family/PF04325 Phobius swissprot:YDCH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDCH_ECOLI ProteinModelPortal P0ACW6 http://www.proteinmodelportal.org/query/uniprot/P0ACW6 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2671655 http://www.ncbi.nlm.nih.gov/pubmed/2671655 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415943 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415943 RefSeq WP_001296778 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001296778 SMR P0ACW6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACW6 STRING 511145.b1426 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1426&targetmode=cogs STRING COG2841 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2841&targetmode=cogs UniProtKB YDCH_ECOLI http://www.uniprot.org/uniprot/YDCH_ECOLI UniProtKB-AC P0ACW6 http://www.uniprot.org/uniprot/P0ACW6 charge swissprot:YDCH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDCH_ECOLI eggNOG COG2841 http://eggnogapi.embl.de/nog_data/html/tree/COG2841 eggNOG ENOG4105Z2P http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105Z2P epestfind swissprot:YDCH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDCH_ECOLI garnier swissprot:YDCH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDCH_ECOLI helixturnhelix swissprot:YDCH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDCH_ECOLI hmoment swissprot:YDCH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDCH_ECOLI iep swissprot:YDCH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDCH_ECOLI inforesidue swissprot:YDCH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDCH_ECOLI octanol swissprot:YDCH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDCH_ECOLI pepcoil swissprot:YDCH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDCH_ECOLI pepdigest swissprot:YDCH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDCH_ECOLI pepinfo swissprot:YDCH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDCH_ECOLI pepnet swissprot:YDCH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDCH_ECOLI pepstats swissprot:YDCH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDCH_ECOLI pepwheel swissprot:YDCH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDCH_ECOLI pepwindow swissprot:YDCH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDCH_ECOLI sigcleave swissprot:YDCH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDCH_ECOLI ## Database ID URL or Descriptions # BioGrid 4261863 15 # EcoGene EG12851 ybeL # IntAct P0AAT9 9 # InterPro IPR009912 DUF1451 # Organism YBEL_ECOLI Escherichia coli (strain K12) # PATRIC 32116469 VBIEscCol129921_0674 # PIR A64799 A64799 # Pfam PF07295 DUF1451 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBEL_ECOLI Uncharacterized protein YbeL # RefSeq NP_415176 NC_000913.3 # RefSeq WP_001044880 NZ_LN832404.1 # eggNOG ENOG4107PAI Bacteria # eggNOG ENOG410XQ93 LUCA BLAST swissprot:YBEL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBEL_ECOLI BioCyc ECOL316407:JW0638-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0638-MONOMER BioCyc EcoCyc:EG12851-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12851-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/15.24.10199 http://dx.doi.org/10.1093/nar/15.24.10199 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EMBL X06331 http://www.ebi.ac.uk/ena/data/view/X06331 EchoBASE EB2696 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2696 EcoGene EG12851 http://www.ecogene.org/geneInfo.php?eg_id=EG12851 EnsemblBacteria AAC73744 http://www.ensemblgenomes.org/id/AAC73744 EnsemblBacteria AAC73744 http://www.ensemblgenomes.org/id/AAC73744 EnsemblBacteria BAA35290 http://www.ensemblgenomes.org/id/BAA35290 EnsemblBacteria BAA35290 http://www.ensemblgenomes.org/id/BAA35290 EnsemblBacteria BAA35290 http://www.ensemblgenomes.org/id/BAA35290 EnsemblBacteria b0643 http://www.ensemblgenomes.org/id/b0643 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945252 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945252 HOGENOM HOG000281678 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000281678&db=HOGENOM6 IntAct P0AAT9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAT9* InterPro IPR009912 http://www.ebi.ac.uk/interpro/entry/IPR009912 KEGG_Gene ecj:JW0638 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0638 KEGG_Gene eco:b0643 http://www.genome.jp/dbget-bin/www_bget?eco:b0643 OMA LEWKEVF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LEWKEVF PSORT swissprot:YBEL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBEL_ECOLI PSORT-B swissprot:YBEL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBEL_ECOLI PSORT2 swissprot:YBEL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBEL_ECOLI Pfam PF07295 http://pfam.xfam.org/family/PF07295 Phobius swissprot:YBEL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBEL_ECOLI ProteinModelPortal P0AAT9 http://www.proteinmodelportal.org/query/uniprot/P0AAT9 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3320963 http://www.ncbi.nlm.nih.gov/pubmed/3320963 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415176 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415176 RefSeq WP_001044880 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001044880 STRING 511145.b0643 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0643&targetmode=cogs UniProtKB YBEL_ECOLI http://www.uniprot.org/uniprot/YBEL_ECOLI UniProtKB-AC P0AAT9 http://www.uniprot.org/uniprot/P0AAT9 charge swissprot:YBEL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBEL_ECOLI eggNOG ENOG4107PAI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107PAI eggNOG ENOG410XQ93 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQ93 epestfind swissprot:YBEL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBEL_ECOLI garnier swissprot:YBEL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBEL_ECOLI helixturnhelix swissprot:YBEL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBEL_ECOLI hmoment swissprot:YBEL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBEL_ECOLI iep swissprot:YBEL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBEL_ECOLI inforesidue swissprot:YBEL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBEL_ECOLI octanol swissprot:YBEL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBEL_ECOLI pepcoil swissprot:YBEL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBEL_ECOLI pepdigest swissprot:YBEL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBEL_ECOLI pepinfo swissprot:YBEL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBEL_ECOLI pepnet swissprot:YBEL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBEL_ECOLI pepstats swissprot:YBEL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBEL_ECOLI pepwheel swissprot:YBEL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBEL_ECOLI pepwindow swissprot:YBEL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBEL_ECOLI sigcleave swissprot:YBEL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBEL_ECOLI ## Database ID URL or Descriptions # BioGrid 4259739 12 # DISRUPTION PHENOTYPE Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain. {ECO:0000269|PubMed 20345943}. # EcoGene EG12325 yadK # FUNCTION YADK_ECOLI Part of the yadCKLM-htrE-yadVN fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. {ECO 0000269|PubMed 20345943}. # GO_component GO:0009289 pilus; IMP:EcoCyc. # GO_process GO:0043709 cell adhesion involved in single-species biofilm formation; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0007155 cell adhesion # Gene3D 2.60.40.1090 -; 1. # INDUCTION Repressed by H-NS. {ECO:0000269|PubMed 20345943}. # InterPro IPR000259 Adhesion_dom_fimbrial # InterPro IPR008966 Adhesion_dom # MISCELLANEOUS The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed. {ECO:0000305|PubMed 20345943}. # Organism YADK_ECOLI Escherichia coli (strain K12) # PATRIC 32115377 VBIEscCol129921_0140 # PIR H64736 H64736 # Pfam PF00419 Fimbrial # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YADK_ECOLI Uncharacterized fimbrial-like protein YadK # RefSeq NP_414678 NC_000913.3 # RefSeq WP_000553749 NZ_LN832404.1 # SIMILARITY Belongs to the fimbrial protein family. {ECO 0000305}. # SUBCELLULAR LOCATION YADK_ECOLI Fimbrium {ECO 0000305}. # SUPFAM SSF49401 SSF49401 # eggNOG ENOG4105SN2 Bacteria # eggNOG ENOG41120VY LUCA BLAST swissprot:YADK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YADK_ECOLI BioCyc ECOL316407:JW0132-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0132-MONOMER BioCyc EcoCyc:EG12325-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12325-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1111/j.1462-2920.2010.02202.x http://dx.doi.org/10.1111/j.1462-2920.2010.02202.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2229 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2229 EcoGene EG12325 http://www.ecogene.org/geneInfo.php?eg_id=EG12325 EnsemblBacteria AAC73247 http://www.ensemblgenomes.org/id/AAC73247 EnsemblBacteria AAC73247 http://www.ensemblgenomes.org/id/AAC73247 EnsemblBacteria BAB96713 http://www.ensemblgenomes.org/id/BAB96713 EnsemblBacteria BAB96713 http://www.ensemblgenomes.org/id/BAB96713 EnsemblBacteria BAB96713 http://www.ensemblgenomes.org/id/BAB96713 EnsemblBacteria b0136 http://www.ensemblgenomes.org/id/b0136 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009289 GO_process GO:0043709 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043709 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 Gene3D 2.60.40.1090 http://www.cathdb.info/version/latest/superfamily/2.60.40.1090 GeneID 944835 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944835 HOGENOM HOG000116878 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000116878&db=HOGENOM6 InterPro IPR000259 http://www.ebi.ac.uk/interpro/entry/IPR000259 InterPro IPR008966 http://www.ebi.ac.uk/interpro/entry/IPR008966 KEGG_Gene ecj:JW0132 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0132 KEGG_Gene eco:b0136 http://www.genome.jp/dbget-bin/www_bget?eco:b0136 OMA ARYQNTG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ARYQNTG PSORT swissprot:YADK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YADK_ECOLI PSORT-B swissprot:YADK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YADK_ECOLI PSORT2 swissprot:YADK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YADK_ECOLI Pfam PF00419 http://pfam.xfam.org/family/PF00419 Phobius swissprot:YADK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YADK_ECOLI ProteinModelPortal P37016 http://www.proteinmodelportal.org/query/uniprot/P37016 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20345943 http://www.ncbi.nlm.nih.gov/pubmed/20345943 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414678 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414678 RefSeq WP_000553749 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000553749 STRING 511145.b0136 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0136&targetmode=cogs SUPFAM SSF49401 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49401 SWISS-2DPAGE P37016 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P37016 UniProtKB YADK_ECOLI http://www.uniprot.org/uniprot/YADK_ECOLI UniProtKB-AC P37016 http://www.uniprot.org/uniprot/P37016 charge swissprot:YADK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YADK_ECOLI eggNOG ENOG4105SN2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105SN2 eggNOG ENOG41120VY http://eggnogapi.embl.de/nog_data/html/tree/ENOG41120VY epestfind swissprot:YADK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YADK_ECOLI garnier swissprot:YADK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YADK_ECOLI helixturnhelix swissprot:YADK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YADK_ECOLI hmoment swissprot:YADK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YADK_ECOLI iep swissprot:YADK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YADK_ECOLI inforesidue swissprot:YADK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YADK_ECOLI octanol swissprot:YADK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YADK_ECOLI pepcoil swissprot:YADK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YADK_ECOLI pepdigest swissprot:YADK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YADK_ECOLI pepinfo swissprot:YADK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YADK_ECOLI pepnet swissprot:YADK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YADK_ECOLI pepstats swissprot:YADK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YADK_ECOLI pepwheel swissprot:YADK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YADK_ECOLI pepwindow swissprot:YADK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YADK_ECOLI sigcleave swissprot:YADK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YADK_ECOLI ## Database ID URL or Descriptions # BioGrid 4260434 8 # DISRUPTION PHENOTYPE Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain. {ECO:0000269|PubMed 20345943}. # EcoGene EG11987 yehA # FUNCTION YEHA_ECOLI Part of the yehABCD fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. {ECO 0000269|PubMed 20345943}. # GO_component GO:0009289 pilus; IEA:InterPro. # GO_process GO:0043709 cell adhesion involved in single-species biofilm formation; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0007155 cell adhesion # Gene3D 2.60.40.1090 -; 1. # INDUCTION Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression. {ECO:0000269|PubMed 20345943}. # InterPro IPR000259 Adhesion_dom_fimbrial # InterPro IPR008966 Adhesion_dom # InterPro IPR016959 UCP030811 # MISCELLANEOUS The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed. {ECO:0000305|PubMed 20345943}. # Organism YEHA_ECOLI Escherichia coli (strain K12) # PATRIC 32119549 VBIEscCol129921_2185 # PIR C64978 C64978 # PIRSF PIRSF030811 UCP030811 # Pfam PF00419 Fimbrial # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEHA_ECOLI Uncharacterized fimbrial-like protein YehA # RefSeq NP_416611 NC_000913.3 # RefSeq WP_000405713 NZ_LN832404.1 # SIMILARITY Belongs to the fimbrial protein family. {ECO 0000305}. # SUPFAM SSF49401 SSF49401 # eggNOG ENOG410662B Bacteria # eggNOG ENOG410XTMS LUCA BLAST swissprot:YEHA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEHA_ECOLI BioCyc ECOL316407:JW2095-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2095-MONOMER BioCyc EcoCyc:EG11987-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11987-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1111/j.1462-2920.2010.02202.x http://dx.doi.org/10.1111/j.1462-2920.2010.02202.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1930 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1930 EcoGene EG11987 http://www.ecogene.org/geneInfo.php?eg_id=EG11987 EnsemblBacteria AAC75169 http://www.ensemblgenomes.org/id/AAC75169 EnsemblBacteria AAC75169 http://www.ensemblgenomes.org/id/AAC75169 EnsemblBacteria BAA15974 http://www.ensemblgenomes.org/id/BAA15974 EnsemblBacteria BAA15974 http://www.ensemblgenomes.org/id/BAA15974 EnsemblBacteria BAA15974 http://www.ensemblgenomes.org/id/BAA15974 EnsemblBacteria b2108 http://www.ensemblgenomes.org/id/b2108 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009289 GO_process GO:0043709 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043709 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 Gene3D 2.60.40.1090 http://www.cathdb.info/version/latest/superfamily/2.60.40.1090 GeneID 946642 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946642 HOGENOM HOG000122132 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122132&db=HOGENOM6 InterPro IPR000259 http://www.ebi.ac.uk/interpro/entry/IPR000259 InterPro IPR008966 http://www.ebi.ac.uk/interpro/entry/IPR008966 InterPro IPR016959 http://www.ebi.ac.uk/interpro/entry/IPR016959 KEGG_Gene ecj:JW2095 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2095 KEGG_Gene eco:b2108 http://www.genome.jp/dbget-bin/www_bget?eco:b2108 OMA IVLRCKN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IVLRCKN PSORT swissprot:YEHA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEHA_ECOLI PSORT-B swissprot:YEHA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEHA_ECOLI PSORT2 swissprot:YEHA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEHA_ECOLI Pfam PF00419 http://pfam.xfam.org/family/PF00419 Phobius swissprot:YEHA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEHA_ECOLI ProteinModelPortal P33340 http://www.proteinmodelportal.org/query/uniprot/P33340 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20345943 http://www.ncbi.nlm.nih.gov/pubmed/20345943 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416611 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416611 RefSeq WP_000405713 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000405713 STRING 511145.b2108 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2108&targetmode=cogs SUPFAM SSF49401 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49401 UniProtKB YEHA_ECOLI http://www.uniprot.org/uniprot/YEHA_ECOLI UniProtKB-AC P33340 http://www.uniprot.org/uniprot/P33340 charge swissprot:YEHA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEHA_ECOLI eggNOG ENOG410662B http://eggnogapi.embl.de/nog_data/html/tree/ENOG410662B eggNOG ENOG410XTMS http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XTMS epestfind swissprot:YEHA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEHA_ECOLI garnier swissprot:YEHA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEHA_ECOLI helixturnhelix swissprot:YEHA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEHA_ECOLI hmoment swissprot:YEHA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEHA_ECOLI iep swissprot:YEHA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEHA_ECOLI inforesidue swissprot:YEHA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEHA_ECOLI octanol swissprot:YEHA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEHA_ECOLI pepcoil swissprot:YEHA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEHA_ECOLI pepdigest swissprot:YEHA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEHA_ECOLI pepinfo swissprot:YEHA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEHA_ECOLI pepnet swissprot:YEHA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEHA_ECOLI pepstats swissprot:YEHA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEHA_ECOLI pepwheel swissprot:YEHA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEHA_ECOLI pepwindow swissprot:YEHA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEHA_ECOLI sigcleave swissprot:YEHA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEHA_ECOLI ## Database ID URL or Descriptions # AltName K1PF_ECOLI Fructose 1-phosphate kinase # BioGrid 4262911 7 # CATALYTIC ACTIVITY K1PF_ECOLI ATP + D-fructose 1-phosphate = ADP + D- fructose 1,6-bisphosphate. # CDD cd01164 FruK_PfkB_like # EcoGene EG10337 fruK # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0008662 1-phosphofructokinase activity; IDA:EcoCyc. # GO_process GO:0006001 fructose catabolic process; IMP:EcoCyc. # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.1190.20 -; 1. # IntAct P0AEW9 2 # InterPro IPR002173 Carboh/pur_kinase_PfkB_CS # InterPro IPR011611 PfkB_dom # InterPro IPR017583 Tagatose/fructose_Pkinase # InterPro IPR022463 1-PFruKinase # InterPro IPR029056 Ribokinase-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00051 Fructose and mannose metabolism # Organism K1PF_ECOLI Escherichia coli (strain K12) # PATRIC 32119685 VBIEscCol129921_2253 # PIR B37245 B37245 # PIRSF PIRSF000535 1PFK/6PFK/LacC # PROSITE PS00583 PFKB_KINASES_1 # PROSITE PS00584 PFKB_KINASES_2 # Pfam PF00294 PfkB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName K1PF_ECOLI 1-phosphofructokinase # RefSeq NP_416673 NC_000913.3 # RefSeq WP_000091263 NZ_LN832404.1 # SIMILARITY Belongs to the carbohydrate kinase PfkB family. {ECO 0000305}. # SUBUNIT K1PF_ECOLI Monomer. # SUPFAM SSF53613 SSF53613 # TIGRFAMs TIGR03168 1-PFK # TIGRFAMs TIGR03828 pfkB # eggNOG COG1105 LUCA # eggNOG ENOG4105DE4 Bacteria BLAST swissprot:K1PF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:K1PF_ECOLI BioCyc ECOL316407:JW2155-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2155-MONOMER BioCyc EcoCyc:1-PFK-MONOMER http://biocyc.org/getid?id=EcoCyc:1-PFK-MONOMER BioCyc MetaCyc:1-PFK-MONOMER http://biocyc.org/getid?id=MetaCyc:1-PFK-MONOMER COG COG1105 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1105 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1098/rspb.1990.0108 http://dx.doi.org/10.1098/rspb.1990.0108 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.56 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.56 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X53948 http://www.ebi.ac.uk/ena/data/view/X53948 ENZYME 2.7.1.56 http://enzyme.expasy.org/EC/2.7.1.56 EchoBASE EB0333 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0333 EcoGene EG10337 http://www.ecogene.org/geneInfo.php?eg_id=EG10337 EnsemblBacteria AAC75229 http://www.ensemblgenomes.org/id/AAC75229 EnsemblBacteria AAC75229 http://www.ensemblgenomes.org/id/AAC75229 EnsemblBacteria BAA15977 http://www.ensemblgenomes.org/id/BAA15977 EnsemblBacteria BAA15977 http://www.ensemblgenomes.org/id/BAA15977 EnsemblBacteria BAA15977 http://www.ensemblgenomes.org/id/BAA15977 EnsemblBacteria b2168 http://www.ensemblgenomes.org/id/b2168 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008662 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008662 GO_process GO:0006001 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006001 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.1190.20 http://www.cathdb.info/version/latest/superfamily/3.40.1190.20 GeneID 946676 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946676 HOGENOM HOG000265280 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000265280&db=HOGENOM6 InParanoid P0AEW9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEW9 IntAct P0AEW9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEW9* IntEnz 2.7.1.56 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.56 InterPro IPR002173 http://www.ebi.ac.uk/interpro/entry/IPR002173 InterPro IPR011611 http://www.ebi.ac.uk/interpro/entry/IPR011611 InterPro IPR017583 http://www.ebi.ac.uk/interpro/entry/IPR017583 InterPro IPR022463 http://www.ebi.ac.uk/interpro/entry/IPR022463 InterPro IPR029056 http://www.ebi.ac.uk/interpro/entry/IPR029056 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2155 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2155 KEGG_Gene eco:b2168 http://www.genome.jp/dbget-bin/www_bget?eco:b2168 KEGG_Orthology KO:K00882 http://www.genome.jp/dbget-bin/www_bget?KO:K00882 KEGG_Pathway ko00051 http://www.genome.jp/kegg-bin/show_pathway?ko00051 KEGG_Reaction rn:R02071 http://www.genome.jp/dbget-bin/www_bget?rn:R02071 OMA NIHEFKC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NIHEFKC PROSITE PS00583 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00583 PROSITE PS00584 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00584 PSORT swissprot:K1PF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:K1PF_ECOLI PSORT-B swissprot:K1PF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:K1PF_ECOLI PSORT2 swissprot:K1PF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:K1PF_ECOLI Pfam PF00294 http://pfam.xfam.org/family/PF00294 Phobius swissprot:K1PF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:K1PF_ECOLI PhylomeDB P0AEW9 http://phylomedb.org/?seqid=P0AEW9 ProteinModelPortal P0AEW9 http://www.proteinmodelportal.org/query/uniprot/P0AEW9 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1981619 http://www.ncbi.nlm.nih.gov/pubmed/1981619 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416673 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416673 RefSeq WP_000091263 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000091263 SMR P0AEW9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEW9 STRING 511145.b2168 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2168&targetmode=cogs STRING COG1105 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1105&targetmode=cogs SUPFAM SSF53613 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53613 TIGRFAMs TIGR03168 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03168 TIGRFAMs TIGR03828 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03828 UniProtKB K1PF_ECOLI http://www.uniprot.org/uniprot/K1PF_ECOLI UniProtKB-AC P0AEW9 http://www.uniprot.org/uniprot/P0AEW9 charge swissprot:K1PF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:K1PF_ECOLI eggNOG COG1105 http://eggnogapi.embl.de/nog_data/html/tree/COG1105 eggNOG ENOG4105DE4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DE4 epestfind swissprot:K1PF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:K1PF_ECOLI garnier swissprot:K1PF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:K1PF_ECOLI helixturnhelix swissprot:K1PF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:K1PF_ECOLI hmoment swissprot:K1PF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:K1PF_ECOLI iep swissprot:K1PF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:K1PF_ECOLI inforesidue swissprot:K1PF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:K1PF_ECOLI octanol swissprot:K1PF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:K1PF_ECOLI pepcoil swissprot:K1PF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:K1PF_ECOLI pepdigest swissprot:K1PF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:K1PF_ECOLI pepinfo swissprot:K1PF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:K1PF_ECOLI pepnet swissprot:K1PF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:K1PF_ECOLI pepstats swissprot:K1PF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:K1PF_ECOLI pepwheel swissprot:K1PF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:K1PF_ECOLI pepwindow swissprot:K1PF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:K1PF_ECOLI sigcleave swissprot:K1PF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:K1PF_ECOLI ## Database ID URL or Descriptions # BioGrid 4261683 163 # EcoGene EG13223 yaeQ # IntAct P0AA97 4 # InterPro IPR009822 YaeQ # InterPro IPR011335 Restrct_endonuc-II-like # Organism YAEQ_ECOLI Escherichia coli (strain K12) # PATRIC 32115493 VBIEscCol129921_0198 # PDB 3C0U X-ray; 2.70 A; A/B=2-181 # PIR F64743 F64743 # PIRSF PIRSF011484 YaeQ # Pfam PF07152 YaeQ # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAEQ_ECOLI Uncharacterized protein YaeQ # RefSeq NP_414732 NC_000913.3 # RefSeq WP_001185290 NZ_LN832404.1 # SMART SM01322 YaeQ # SUPFAM SSF52980 SSF52980 # eggNOG COG4681 LUCA # eggNOG ENOG4108VWS Bacteria BLAST swissprot:YAEQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAEQ_ECOLI BioCyc ECOL316407:JW0186-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0186-MONOMER BioCyc EcoCyc:G6098-MONOMER http://biocyc.org/getid?id=EcoCyc:G6098-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D49445 http://www.ebi.ac.uk/ena/data/view/D49445 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EchoBASE EB3014 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3014 EcoGene EG13223 http://www.ecogene.org/geneInfo.php?eg_id=EG13223 EnsemblBacteria AAC73301 http://www.ensemblgenomes.org/id/AAC73301 EnsemblBacteria AAC73301 http://www.ensemblgenomes.org/id/AAC73301 EnsemblBacteria BAA77866 http://www.ensemblgenomes.org/id/BAA77866 EnsemblBacteria BAA77866 http://www.ensemblgenomes.org/id/BAA77866 EnsemblBacteria BAA77866 http://www.ensemblgenomes.org/id/BAA77866 EnsemblBacteria b0190 http://www.ensemblgenomes.org/id/b0190 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946809 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946809 HOGENOM HOG000266235 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000266235&db=HOGENOM6 InParanoid P0AA97 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AA97 IntAct P0AA97 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AA97* InterPro IPR009822 http://www.ebi.ac.uk/interpro/entry/IPR009822 InterPro IPR011335 http://www.ebi.ac.uk/interpro/entry/IPR011335 KEGG_Gene ecj:JW0186 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0186 KEGG_Gene eco:b0190 http://www.genome.jp/dbget-bin/www_bget?eco:b0190 OMA RHPSEND http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RHPSEND PDB 3C0U http://www.ebi.ac.uk/pdbe-srv/view/entry/3C0U PDBsum 3C0U http://www.ebi.ac.uk/pdbsum/3C0U PSORT swissprot:YAEQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAEQ_ECOLI PSORT-B swissprot:YAEQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAEQ_ECOLI PSORT2 swissprot:YAEQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAEQ_ECOLI Pfam PF07152 http://pfam.xfam.org/family/PF07152 Phobius swissprot:YAEQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAEQ_ECOLI PhylomeDB P0AA97 http://phylomedb.org/?seqid=P0AA97 ProteinModelPortal P0AA97 http://www.proteinmodelportal.org/query/uniprot/P0AA97 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414732 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414732 RefSeq WP_001185290 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001185290 SMART SM01322 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01322 SMR P0AA97 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AA97 STRING 511145.b0190 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0190&targetmode=cogs SUPFAM SSF52980 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52980 UniProtKB YAEQ_ECOLI http://www.uniprot.org/uniprot/YAEQ_ECOLI UniProtKB-AC P0AA97 http://www.uniprot.org/uniprot/P0AA97 charge swissprot:YAEQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAEQ_ECOLI eggNOG COG4681 http://eggnogapi.embl.de/nog_data/html/tree/COG4681 eggNOG ENOG4108VWS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108VWS epestfind swissprot:YAEQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAEQ_ECOLI garnier swissprot:YAEQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAEQ_ECOLI helixturnhelix swissprot:YAEQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAEQ_ECOLI hmoment swissprot:YAEQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAEQ_ECOLI iep swissprot:YAEQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAEQ_ECOLI inforesidue swissprot:YAEQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAEQ_ECOLI octanol swissprot:YAEQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAEQ_ECOLI pepcoil swissprot:YAEQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAEQ_ECOLI pepdigest swissprot:YAEQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAEQ_ECOLI pepinfo swissprot:YAEQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAEQ_ECOLI pepnet swissprot:YAEQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAEQ_ECOLI pepstats swissprot:YAEQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAEQ_ECOLI pepwheel swissprot:YAEQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAEQ_ECOLI pepwindow swissprot:YAEQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAEQ_ECOLI sigcleave swissprot:YAEQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAEQ_ECOLI ## Database ID URL or Descriptions # AltName Cold-shock DEAD box protein A {ECO:0000255|HAMAP-Rule MF_00964} # AltName DEAD_ECOLI Translation factor W2 # BioGrid 4262429 117 # CATALYTIC ACTIVITY DEAD_ECOLI ATP + H(2)O = ADP + phosphate. {ECO 0000255|HAMAP-Rule MF_00964, ECO 0000269|PubMed 15196029, ECO 0000269|PubMed 17259309}. # CAUTION DEAD_ECOLI It is unclear whether it requires ATP according to PubMed 8552679 and PubMed 10216955, it does not require ATP, while according to PubMed 15196029, PubMed 15554978 and PubMed 17259309, it requires ATP. {ECO 0000305}. # DISRUPTION PHENOTYPE DEAD_ECOLI Cells lacking this gene grow very poorly at 15-20 degrees Celsius and accumulate an abnormal large ribosomal subunit. {ECO 0000269|PubMed 15148362, ECO 0000269|PubMed 8552679}. # EcoGene EG10215 deaD # FUNCTION DEAD_ECOLI DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation. Exhibits RNA-stimulated ATP hydrolysis and RNA unwinding activity at low temperature. Involved in 50S ribosomal subunit assembly, acting after SrmB, and could also play a role in the biogenesis of the 30S ribosomal subunit. In addition, is involved in mRNA decay, via formation of a cold-shock degradosome with RNase E. Also stimulates translation of some mRNAs, probably at the level of initiation. {ECO 0000255|HAMAP-Rule MF_00964, ECO 0000269|PubMed 10216955, ECO 0000269|PubMed 15148362, ECO 0000269|PubMed 15196029, ECO 0000269|PubMed 15554978, ECO 0000269|PubMed 17259309, ECO 0000269|PubMed 8552679}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003724 RNA helicase activity; IDA:EcoCyc. # GO_function GO:0004004 ATP-dependent RNA helicase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0033592 RNA strand annealing activity; IDA:EcoCyc. # GO_process GO:0000027 ribosomal large subunit assembly; IMP:EcoCyc. # GO_process GO:0006401 RNA catabolic process; IGI:EcoCyc. # GO_process GO:0010501 RNA secondary structure unwinding; IBA:GO_Central. # GO_process GO:0045727 positive regulation of translation; IMP:EcoCyc. # GO_process GO:0048255 mRNA stabilization; IMP:CACAO. # GO_process GO:0070417 cellular response to cold; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0004386 helicase activity # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0022618 ribonucleoprotein complex assembly # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # Gene3D 3.40.50.300 -; 2. # HAMAP MF_00964 DEAD_helicase_DeaD # INDUCTION In response to low temperature. {ECO:0000269|PubMed 8552679}. # IntAct P0A9P6 84 # InterPro IPR000629 RNA-helicase_DEAD-box_CS # InterPro IPR001650 Helicase_C # InterPro IPR005580 DbpA_RNA-bd_dom # InterPro IPR011545 DEAD/DEAH_box_helicase_dom # InterPro IPR014001 Helicase_ATP-bd # InterPro IPR014014 RNA_helicase_DEAD_Q_motif # InterPro IPR021046 Cold-shock_DEAD_Abox_C # InterPro IPR027417 P-loop_NTPase # InterPro IPR028618 DEAD_helicase_DeaD # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # KEGG_Pathway ko03018 RNA degradation # MISCELLANEOUS DEAD_ECOLI When overexpressed suppresses cold-sensitive mutants of rpsB (ribosomal protein S2) (PubMed 2045359) and pyrH/smbA2 (uridylate kinase) (PubMed 8190075). {ECO 0000305|PubMed 2045359, ECO 0000305|PubMed 8190075}. # Organism DEAD_ECOLI Escherichia coli (strain K12) # PATRIC 32121742 VBIEscCol129921_3257 # PIR F65106 F65106 # PROSITE PS00039 DEAD_ATP_HELICASE # PROSITE PS51192 HELICASE_ATP_BIND_1 # PROSITE PS51194 HELICASE_CTER # PROSITE PS51195 Q_MOTIF # Pfam PF00270 DEAD # Pfam PF00271 Helicase_C # Pfam PF03880 DbpA # Pfam PF12343 DEADboxA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ATP-dependent RNA helicase DeaD {ECO:0000255|HAMAP-Rule MF_00964} # RefSeq NP_417631 NC_000913.3 # RefSeq WP_001295553 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA23674.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAA23674.1; Type=Frameshift; Positions=536, 565; Evidence={ECO 0000305}; Sequence=AAA57965.1; Type=Erroneous initiation; Evidence={ECO:0000305}; # SIMILARITY Belongs to the DEAD box helicase family. DeaD subfamily. {ECO:0000255|HAMAP-Rule MF_00964}. # SIMILARITY Contains 1 helicase ATP-binding domain. {ECO:0000255|HAMAP-Rule MF_00964}. # SIMILARITY Contains 1 helicase C-terminal domain. {ECO:0000255|HAMAP-Rule MF_00964}. # SMART SM00487 DEXDc # SMART SM00490 HELICc # SUBCELLULAR LOCATION DEAD_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00964, ECO 0000269|PubMed 8552679}. # SUBUNIT DEAD_ECOLI Interacts with the 50S ribosomal subunit upon shifting to 15 degrees Celsius. Also found associated with the RNA degradosome at 15 degrees Celsius; binds RNase E (rne). {ECO 0000269|PubMed 15148362, ECO 0000269|PubMed 15554978, ECO 0000269|PubMed 8552679}. # SUPFAM SSF52540 SSF52540 # eggNOG COG0513 LUCA # eggNOG ENOG4105C1J Bacteria BLAST swissprot:DEAD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DEAD_ECOLI BioCyc ECOL316407:JW5531-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5531-MONOMER BioCyc EcoCyc:EG10215-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10215-MONOMER COG COG0513 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0513 DIP DIP-35752N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35752N DOI 10.1007/BF00283870 http://dx.doi.org/10.1007/BF00283870 DOI 10.1016/S1357-2725(98)00142-3 http://dx.doi.org/10.1016/S1357-2725(98)00142-3 DOI 10.1021/bi049852s http://dx.doi.org/10.1021/bi049852s DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.93.1.76 http://dx.doi.org/10.1073/pnas.93.1.76 DOI 10.1093/nar/gkh603 http://dx.doi.org/10.1093/nar/gkh603 DOI 10.1111/j.1365-2958.2004.04360.x http://dx.doi.org/10.1111/j.1365-2958.2004.04360.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01509-06 http://dx.doi.org/10.1128/JB.01509-06 EC_number EC:3.6.4.13 {ECO:0000255|HAMAP-Rule:MF_00964} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.4.13 {ECO:0000255|HAMAP-Rule:MF_00964} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M63288 http://www.ebi.ac.uk/ena/data/view/M63288 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U03750 http://www.ebi.ac.uk/ena/data/view/U03750 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 3.6.4.13 {ECO:0000255|HAMAP-Rule:MF_00964} http://enzyme.expasy.org/EC/3.6.4.13 {ECO:0000255|HAMAP-Rule:MF_00964} EchoBASE EB0211 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0211 EcoGene EG10215 http://www.ecogene.org/geneInfo.php?eg_id=EG10215 EnsemblBacteria AAC76196 http://www.ensemblgenomes.org/id/AAC76196 EnsemblBacteria AAC76196 http://www.ensemblgenomes.org/id/AAC76196 EnsemblBacteria BAE77208 http://www.ensemblgenomes.org/id/BAE77208 EnsemblBacteria BAE77208 http://www.ensemblgenomes.org/id/BAE77208 EnsemblBacteria BAE77208 http://www.ensemblgenomes.org/id/BAE77208 EnsemblBacteria b3162 http://www.ensemblgenomes.org/id/b3162 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003724 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003724 GO_function GO:0004004 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004004 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0033592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033592 GO_process GO:0000027 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000027 GO_process GO:0006401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006401 GO_process GO:0010501 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010501 GO_process GO:0045727 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045727 GO_process GO:0048255 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048255 GO_process GO:0070417 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070417 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0004386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004386 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0022618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022618 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947674 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947674 HAMAP MF_00964 http://hamap.expasy.org/unirule/MF_00964 HOGENOM HOG000268810 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000268810&db=HOGENOM6 InParanoid P0A9P6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9P6 IntAct P0A9P6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9P6* IntEnz 3.6.4.13 {ECO:0000255|HAMAP-Rule:MF_00964} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.4.13 {ECO:0000255|HAMAP-Rule:MF_00964} InterPro IPR000629 http://www.ebi.ac.uk/interpro/entry/IPR000629 InterPro IPR001650 http://www.ebi.ac.uk/interpro/entry/IPR001650 InterPro IPR005580 http://www.ebi.ac.uk/interpro/entry/IPR005580 InterPro IPR011545 http://www.ebi.ac.uk/interpro/entry/IPR011545 InterPro IPR014001 http://www.ebi.ac.uk/interpro/entry/IPR014001 InterPro IPR014014 http://www.ebi.ac.uk/interpro/entry/IPR014014 InterPro IPR021046 http://www.ebi.ac.uk/interpro/entry/IPR021046 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR028618 http://www.ebi.ac.uk/interpro/entry/IPR028618 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW5531 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5531 KEGG_Gene eco:b3162 http://www.genome.jp/dbget-bin/www_bget?eco:b3162 KEGG_Orthology KO:K05592 http://www.genome.jp/dbget-bin/www_bget?KO:K05592 KEGG_Pathway ko03018 http://www.genome.jp/kegg-bin/show_pathway?ko03018 MINT MINT-1219396 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1219396 OMA TEGNATY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TEGNATY PROSITE PS00039 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00039 PROSITE PS51192 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51192 PROSITE PS51194 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51194 PROSITE PS51195 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51195 PSORT swissprot:DEAD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DEAD_ECOLI PSORT-B swissprot:DEAD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DEAD_ECOLI PSORT2 swissprot:DEAD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DEAD_ECOLI Pfam PF00270 http://pfam.xfam.org/family/PF00270 Pfam PF00271 http://pfam.xfam.org/family/PF00271 Pfam PF03880 http://pfam.xfam.org/family/PF03880 Pfam PF12343 http://pfam.xfam.org/family/PF12343 Phobius swissprot:DEAD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DEAD_ECOLI PhylomeDB P0A9P6 http://phylomedb.org/?seqid=P0A9P6 ProteinModelPortal P0A9P6 http://www.proteinmodelportal.org/query/uniprot/P0A9P6 PubMed 10216955 http://www.ncbi.nlm.nih.gov/pubmed/10216955 PubMed 15148362 http://www.ncbi.nlm.nih.gov/pubmed/15148362 PubMed 15196029 http://www.ncbi.nlm.nih.gov/pubmed/15196029 PubMed 15554978 http://www.ncbi.nlm.nih.gov/pubmed/15554978 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17259309 http://www.ncbi.nlm.nih.gov/pubmed/17259309 PubMed 2045359 http://www.ncbi.nlm.nih.gov/pubmed/2045359 PubMed 8056751 http://www.ncbi.nlm.nih.gov/pubmed/8056751 PubMed 8190075 http://www.ncbi.nlm.nih.gov/pubmed/8190075 PubMed 8552679 http://www.ncbi.nlm.nih.gov/pubmed/8552679 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417631 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417631 RefSeq WP_001295553 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295553 SMART SM00487 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00487 SMART SM00490 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00490 SMR P0A9P6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9P6 STRING 511145.b3162 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3162&targetmode=cogs STRING COG0513 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0513&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SWISS-2DPAGE P0A9P6 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A9P6 UniProtKB DEAD_ECOLI http://www.uniprot.org/uniprot/DEAD_ECOLI UniProtKB-AC P0A9P6 http://www.uniprot.org/uniprot/P0A9P6 charge swissprot:DEAD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DEAD_ECOLI eggNOG COG0513 http://eggnogapi.embl.de/nog_data/html/tree/COG0513 eggNOG ENOG4105C1J http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C1J epestfind swissprot:DEAD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DEAD_ECOLI garnier swissprot:DEAD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DEAD_ECOLI helixturnhelix swissprot:DEAD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DEAD_ECOLI hmoment swissprot:DEAD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DEAD_ECOLI iep swissprot:DEAD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DEAD_ECOLI inforesidue swissprot:DEAD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DEAD_ECOLI octanol swissprot:DEAD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DEAD_ECOLI pepcoil swissprot:DEAD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DEAD_ECOLI pepdigest swissprot:DEAD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DEAD_ECOLI pepinfo swissprot:DEAD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DEAD_ECOLI pepnet swissprot:DEAD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DEAD_ECOLI pepstats swissprot:DEAD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DEAD_ECOLI pepwheel swissprot:DEAD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DEAD_ECOLI pepwindow swissprot:DEAD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DEAD_ECOLI sigcleave swissprot:DEAD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DEAD_ECOLI ## Database ID URL or Descriptions # BioGrid 4260233 6 # EcoGene EG12451 rspA # FUNCTION RSPA_ECOLI Probably involved in the degradation of homoserine lactone (HSL) or of a metabolite of HSL that signals starvation. # GO_function GO:0003824 catalytic activity; IEA:InterPro. # GO_process GO:0009063 cellular amino acid catabolic process; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # Gene3D 3.20.20.120 -; 1. # Gene3D 3.30.390.10 -; 1. # INDUCTION Repressed by RspR. {ECO:0000269|PubMed 22972332}. # IntAct P38104 11 # InterPro IPR001354 MR/MLE/MAL # InterPro IPR013341 Mandelate_racemase_N_dom # InterPro IPR013342 Mandelate_racemase_C # InterPro IPR018110 Mandel_Rmase/mucon_lact_enz_CS # InterPro IPR029017 Enolase_N-like # InterPro IPR029065 Enolase_C-like # MISCELLANEOUS Overexpression prevents homoserine lactone- dependent synthesis of the sigma S factor (rpoS). {ECO:0000269|PubMed 7545940}. # Organism RSPA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR13794 PTHR13794; 2 # PATRIC 32118464 VBIEscCol129921_1652 # PIR I59589 I59589 # PROSITE PS00908 MR_MLE_1 # PROSITE PS00909 MR_MLE_2 # Pfam PF02746 MR_MLE_N # Pfam PF13378 MR_MLE_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RSPA_ECOLI Starvation-sensing protein RspA # RefSeq NP_416098 NC_000913.3 # RefSeq WP_001295394 NZ_LN832404.1 # SIMILARITY Belongs to the mandelate racemase/muconate lactonizing enzyme family. {ECO 0000305}. # SMART SM00922 MR_MLE # SUPFAM SSF51604 SSF51604 # SUPFAM SSF54826 SSF54826 # eggNOG COG4948 LUCA # eggNOG ENOG4105CXK Bacteria BLAST swissprot:RSPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RSPA_ECOLI BioCyc ECOL316407:JW1573-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1573-MONOMER BioCyc EcoCyc:G6839-MONOMER http://biocyc.org/getid?id=EcoCyc:G6839-MONOMER COG COG4948 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4948 DIP DIP-10805N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10805N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1126/science.7545940 http://dx.doi.org/10.1126/science.7545940 DOI 10.1271/bbb.120273 http://dx.doi.org/10.1271/bbb.120273 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L31628 http://www.ebi.ac.uk/ena/data/view/L31628 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2345 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2345 EcoGene EG12451 http://www.ecogene.org/geneInfo.php?eg_id=EG12451 EnsemblBacteria AAC74653 http://www.ensemblgenomes.org/id/AAC74653 EnsemblBacteria AAC74653 http://www.ensemblgenomes.org/id/AAC74653 EnsemblBacteria BAA15285 http://www.ensemblgenomes.org/id/BAA15285 EnsemblBacteria BAA15285 http://www.ensemblgenomes.org/id/BAA15285 EnsemblBacteria BAA15285 http://www.ensemblgenomes.org/id/BAA15285 EnsemblBacteria b1581 http://www.ensemblgenomes.org/id/b1581 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003824 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003824 GO_process GO:0009063 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009063 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 3.20.20.120 http://www.cathdb.info/version/latest/superfamily/3.20.20.120 Gene3D 3.30.390.10 http://www.cathdb.info/version/latest/superfamily/3.30.390.10 GeneID 946126 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946126 HOGENOM HOG000113758 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000113758&db=HOGENOM6 InParanoid P38104 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P38104 IntAct P38104 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P38104* InterPro IPR001354 http://www.ebi.ac.uk/interpro/entry/IPR001354 InterPro IPR013341 http://www.ebi.ac.uk/interpro/entry/IPR013341 InterPro IPR013342 http://www.ebi.ac.uk/interpro/entry/IPR013342 InterPro IPR018110 http://www.ebi.ac.uk/interpro/entry/IPR018110 InterPro IPR029017 http://www.ebi.ac.uk/interpro/entry/IPR029017 InterPro IPR029065 http://www.ebi.ac.uk/interpro/entry/IPR029065 KEGG_Gene ecj:JW1573 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1573 KEGG_Gene eco:b1581 http://www.genome.jp/dbget-bin/www_bget?eco:b1581 KEGG_Orthology KO:K08323 http://www.genome.jp/dbget-bin/www_bget?KO:K08323 OMA SIEEFRM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SIEEFRM PANTHER PTHR13794 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13794 PROSITE PS00908 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00908 PROSITE PS00909 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00909 PSORT swissprot:RSPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RSPA_ECOLI PSORT-B swissprot:RSPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RSPA_ECOLI PSORT2 swissprot:RSPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RSPA_ECOLI Pfam PF02746 http://pfam.xfam.org/family/PF02746 Pfam PF13378 http://pfam.xfam.org/family/PF13378 Phobius swissprot:RSPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RSPA_ECOLI PhylomeDB P38104 http://phylomedb.org/?seqid=P38104 ProteinModelPortal P38104 http://www.proteinmodelportal.org/query/uniprot/P38104 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22972332 http://www.ncbi.nlm.nih.gov/pubmed/22972332 PubMed 7545940 http://www.ncbi.nlm.nih.gov/pubmed/7545940 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416098 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416098 RefSeq WP_001295394 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295394 SMART SM00922 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00922 SMR P38104 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P38104 STRING 511145.b1581 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1581&targetmode=cogs STRING COG4948 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4948&targetmode=cogs SUPFAM SSF51604 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51604 SUPFAM SSF54826 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54826 UniProtKB RSPA_ECOLI http://www.uniprot.org/uniprot/RSPA_ECOLI UniProtKB-AC P38104 http://www.uniprot.org/uniprot/P38104 charge swissprot:RSPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RSPA_ECOLI eggNOG COG4948 http://eggnogapi.embl.de/nog_data/html/tree/COG4948 eggNOG ENOG4105CXK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CXK epestfind swissprot:RSPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RSPA_ECOLI garnier swissprot:RSPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RSPA_ECOLI helixturnhelix swissprot:RSPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RSPA_ECOLI hmoment swissprot:RSPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RSPA_ECOLI iep swissprot:RSPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RSPA_ECOLI inforesidue swissprot:RSPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RSPA_ECOLI octanol swissprot:RSPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RSPA_ECOLI pepcoil swissprot:RSPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RSPA_ECOLI pepdigest swissprot:RSPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RSPA_ECOLI pepinfo swissprot:RSPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RSPA_ECOLI pepnet swissprot:RSPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RSPA_ECOLI pepstats swissprot:RSPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RSPA_ECOLI pepwheel swissprot:RSPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RSPA_ECOLI pepwindow swissprot:RSPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RSPA_ECOLI sigcleave swissprot:RSPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RSPA_ECOLI ## Database ID URL or Descriptions # AltName NADH dehydrogenase I subunit K {ECO:0000255|HAMAP-Rule MF_01456} # AltName NDH-1 subunit K {ECO:0000255|HAMAP-Rule MF_01456} # AltName NUOK_ECOLI NUO11 # BioGrid 4260508 39 # CATALYTIC ACTIVITY NADH + a quinone = NAD(+) + a quinol. {ECO:0000255|HAMAP-Rule MF_01456}. # EcoGene EG12091 nuoK # FUNCTION NUOK_ECOLI NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. # FUNCTION NUOK_ECOLI There are 2 NADH dehydrogenases in E.coli, however only this complex is able to use dNADH (reduced nicotinamide hypoxanthine dinucleotide, deamino-NADH) and dNADH-DB (dimethoxy- 5-methyl-6-decyl-1,4-benzoquinone) as substrates. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0030964 NADH dehydrogenase complex; IDA:EcoliWiki. # GO_component GO:0045272 plasma membrane respiratory chain complex I; IDA:EcoCyc. # GO_function GO:0008137 NADH dehydrogenase (ubiquinone) activity; IMP:EcoCyc. # GO_function GO:0048038 quinone binding; IEA:UniProtKB-KW. # GO_process GO:0006810 transport; IEA:UniProtKB-KW. # GO_process GO:0042773 ATP synthesis coupled electron transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0006810 transport # HAMAP MF_01456 NDH1_NuoK # InterPro IPR001133 NADH_UbQ_OxRdtase_chain4L/K # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00190 Oxidative phosphorylation # KEGG_Pathway ko00910 Nitrogen metabolism # Organism NUOK_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11434 PTHR11434 # PATRIC 32119925 VBIEscCol129921_2372 # PIR E64999 E64999 # PIR S38320 S37068 # Pfam PF00420 Oxidored_q2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NADH-quinone oxidoreductase subunit K {ECO:0000255|HAMAP-Rule MF_01456} # RefSeq NP_416782 NC_000913.3 # RefSeq WP_000612644 NZ_LN832404.1 # SIMILARITY Belongs to the complex I subunit 4L family. {ECO:0000255|HAMAP-Rule MF_01456}. # SUBCELLULAR LOCATION NUOK_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT NUOK_ECOLI NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex. # TCDB 3.D.1.1 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family # eggNOG COG0713 LUCA BLAST swissprot:NUOK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NUOK_ECOLI BioCyc ECOL316407:JW2274-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2274-MONOMER BioCyc EcoCyc:NUOK-MONOMER http://biocyc.org/getid?id=EcoCyc:NUOK-MONOMER BioCyc MetaCyc:NUOK-MONOMER http://biocyc.org/getid?id=MetaCyc:NUOK-MONOMER COG COG0713 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0713 DIP DIP-51165N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-51165N DOI 10.1006/jmbi.1993.1488 http://dx.doi.org/10.1006/jmbi.1993.1488 DOI 10.1021/bi050708w http://dx.doi.org/10.1021/bi050708w DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.6.5.11 {ECO:0000255|HAMAP-Rule:MF_01456} http://www.genome.jp/dbget-bin/www_bget?EC:1.6.5.11 {ECO:0000255|HAMAP-Rule:MF_01456} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X68301 http://www.ebi.ac.uk/ena/data/view/X68301 ENZYME 1.6.5.11 {ECO:0000255|HAMAP-Rule:MF_01456} http://enzyme.expasy.org/EC/1.6.5.11 {ECO:0000255|HAMAP-Rule:MF_01456} EchoBASE EB2015 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2015 EcoGene EG12091 http://www.ecogene.org/geneInfo.php?eg_id=EG12091 EnsemblBacteria AAC75339 http://www.ensemblgenomes.org/id/AAC75339 EnsemblBacteria AAC75339 http://www.ensemblgenomes.org/id/AAC75339 EnsemblBacteria BAA16107 http://www.ensemblgenomes.org/id/BAA16107 EnsemblBacteria BAA16107 http://www.ensemblgenomes.org/id/BAA16107 EnsemblBacteria BAA16107 http://www.ensemblgenomes.org/id/BAA16107 EnsemblBacteria b2279 http://www.ensemblgenomes.org/id/b2279 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0030964 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030964 GO_component GO:0045272 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045272 GO_function GO:0008137 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008137 GO_function GO:0048038 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048038 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GO_process GO:0042773 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042773 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 947580 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947580 HAMAP MF_01456 http://hamap.expasy.org/unirule/MF_01456 HOGENOM HOG000066429 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000066429&db=HOGENOM6 InParanoid P0AFE4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFE4 IntAct P0AFE4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFE4* IntEnz 1.6.5.11 {ECO:0000255|HAMAP-Rule:MF_01456} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.6.5.11 {ECO:0000255|HAMAP-Rule:MF_01456} InterPro IPR001133 http://www.ebi.ac.uk/interpro/entry/IPR001133 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2274 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2274 KEGG_Gene eco:b2279 http://www.genome.jp/dbget-bin/www_bget?eco:b2279 KEGG_Orthology KO:K00340 http://www.genome.jp/dbget-bin/www_bget?KO:K00340 KEGG_Pathway ko00190 http://www.genome.jp/kegg-bin/show_pathway?ko00190 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Reaction rn:R02166 http://www.genome.jp/dbget-bin/www_bget?rn:R02166 OMA NFVAFSY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NFVAFSY PANTHER PTHR11434 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11434 PSORT swissprot:NUOK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NUOK_ECOLI PSORT-B swissprot:NUOK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NUOK_ECOLI PSORT2 swissprot:NUOK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NUOK_ECOLI Pfam PF00420 http://pfam.xfam.org/family/PF00420 Phobius swissprot:NUOK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NUOK_ECOLI PhylomeDB P0AFE4 http://phylomedb.org/?seqid=P0AFE4 ProteinModelPortal P0AFE4 http://www.proteinmodelportal.org/query/uniprot/P0AFE4 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 15996109 http://www.ncbi.nlm.nih.gov/pubmed/15996109 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7690854 http://www.ncbi.nlm.nih.gov/pubmed/7690854 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416782 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416782 RefSeq WP_000612644 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000612644 SMR P0AFE4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFE4 STRING 511145.b2279 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2279&targetmode=cogs STRING COG0713 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0713&targetmode=cogs TCDB 3.D.1.1 http://www.tcdb.org/search/result.php?tc=3.D.1.1 UniProtKB NUOK_ECOLI http://www.uniprot.org/uniprot/NUOK_ECOLI UniProtKB-AC P0AFE4 http://www.uniprot.org/uniprot/P0AFE4 charge swissprot:NUOK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NUOK_ECOLI eggNOG COG0713 http://eggnogapi.embl.de/nog_data/html/tree/COG0713 epestfind swissprot:NUOK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NUOK_ECOLI garnier swissprot:NUOK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NUOK_ECOLI helixturnhelix swissprot:NUOK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NUOK_ECOLI hmoment swissprot:NUOK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NUOK_ECOLI iep swissprot:NUOK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NUOK_ECOLI inforesidue swissprot:NUOK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NUOK_ECOLI octanol swissprot:NUOK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NUOK_ECOLI pepcoil swissprot:NUOK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NUOK_ECOLI pepdigest swissprot:NUOK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NUOK_ECOLI pepinfo swissprot:NUOK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NUOK_ECOLI pepnet swissprot:NUOK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NUOK_ECOLI pepstats swissprot:NUOK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NUOK_ECOLI pepwheel swissprot:NUOK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NUOK_ECOLI pepwindow swissprot:NUOK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NUOK_ECOLI sigcleave swissprot:NUOK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NUOK_ECOLI ## Database ID URL or Descriptions # AltName ALLR_ECOLI Negative regulator of allantoin and glyoxylate utilization operons # BioGrid 4259871 6 # EcoGene EG13616 allR # FUNCTION ALLR_ECOLI Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region. Binding to DNA is abolished by glyoxylate. {ECO 0000269|PubMed 10601204, ECO 0000269|PubMed 12460564, ECO 0000269|PubMed 16546208}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IBA:GO_Central. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # Gene3D 3.30.450.40 -; 1. # INTERACTION ALLR_ECOLI Self; NbExp=4; IntAct=EBI-561736, EBI-561736; P31552 caiC; NbExp=3; IntAct=EBI-561736, EBI-1112975; # IntAct P0ACN4 21 # InterPro IPR005471 Tscrpt_reg_IclR_N # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR014757 Tscrpt_reg_IclR_C # InterPro IPR029016 GAF_dom-like # KEGG_Brite ko03000 Transcription factors # Organism ALLR_ECOLI Escherichia coli (strain K12) # PATRIC 32116171 VBIEscCol129921_0527 # PDB 1TF1 X-ray; 1.80 A; A/B/C/D=97-271 # PIR A64782 A64782 # PROSITE PS51077 HTH_ICLR # PROSITE PS51078 ICLR_ED # Pfam PF01614 IclR # Pfam PF09339 HTH_IclR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ALLR_ECOLI HTH-type transcriptional repressor AllR # RefSeq NP_415039 NC_000913.3 # RefSeq WP_000141275 NZ_LN832404.1 # SIMILARITY Contains 1 HTH iclR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00393}. # SIMILARITY Contains 1 iclR-ED (iclR effector binding) domain. {ECO:0000255|PROSITE-ProRule PRU00394}. # SMART SM00346 HTH_ICLR # SUBUNIT Homotetramer and homodimer. Homotetramer in its active, DNA-bound form. Homodimer in its inactive form. {ECO:0000269|PubMed 16546208}. # SUPFAM SSF46785 SSF46785 # SUPFAM SSF55781 SSF55781 # eggNOG COG1414 LUCA # eggNOG ENOG4108N16 Bacteria BLAST swissprot:ALLR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ALLR_ECOLI BioCyc ECOL316407:JW0494-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0494-MONOMER BioCyc EcoCyc:G6276-MONOMER http://biocyc.org/getid?id=EcoCyc:G6276-MONOMER COG COG1414 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1414 DIP DIP-47907N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47907N DOI 10.1016/S0022-2836(02)01134-8 http://dx.doi.org/10.1016/S0022-2836(02)01134-8 DOI 10.1016/j.jmb.2006.02.034 http://dx.doi.org/10.1016/j.jmb.2006.02.034 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL U89024 http://www.ebi.ac.uk/ena/data/view/U89024 EchoBASE EB3382 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3382 EcoGene EG13616 http://www.ecogene.org/geneInfo.php?eg_id=EG13616 EnsemblBacteria AAC73608 http://www.ensemblgenomes.org/id/AAC73608 EnsemblBacteria AAC73608 http://www.ensemblgenomes.org/id/AAC73608 EnsemblBacteria BAE76284 http://www.ensemblgenomes.org/id/BAE76284 EnsemblBacteria BAE76284 http://www.ensemblgenomes.org/id/BAE76284 EnsemblBacteria BAE76284 http://www.ensemblgenomes.org/id/BAE76284 EnsemblBacteria b0506 http://www.ensemblgenomes.org/id/b0506 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 3.30.450.40 http://www.cathdb.info/version/latest/superfamily/3.30.450.40 GeneID 945333 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945333 HOGENOM HOG000107041 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000107041&db=HOGENOM6 InParanoid P0ACN4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACN4 IntAct P0ACN4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACN4* InterPro IPR005471 http://www.ebi.ac.uk/interpro/entry/IPR005471 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR014757 http://www.ebi.ac.uk/interpro/entry/IPR014757 InterPro IPR029016 http://www.ebi.ac.uk/interpro/entry/IPR029016 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW0494 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0494 KEGG_Gene eco:b0506 http://www.genome.jp/dbget-bin/www_bget?eco:b0506 KEGG_Orthology KO:K10973 http://www.genome.jp/dbget-bin/www_bget?KO:K10973 OMA APNTITC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=APNTITC PDB 1TF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1TF1 PDBsum 1TF1 http://www.ebi.ac.uk/pdbsum/1TF1 PROSITE PS51077 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51077 PROSITE PS51078 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51078 PSORT swissprot:ALLR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ALLR_ECOLI PSORT-B swissprot:ALLR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ALLR_ECOLI PSORT2 swissprot:ALLR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ALLR_ECOLI Pfam PF01614 http://pfam.xfam.org/family/PF01614 Pfam PF09339 http://pfam.xfam.org/family/PF09339 Phobius swissprot:ALLR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ALLR_ECOLI PhylomeDB P0ACN4 http://phylomedb.org/?seqid=P0ACN4 ProteinModelPortal P0ACN4 http://www.proteinmodelportal.org/query/uniprot/P0ACN4 PubMed 10601204 http://www.ncbi.nlm.nih.gov/pubmed/10601204 PubMed 12460564 http://www.ncbi.nlm.nih.gov/pubmed/12460564 PubMed 16546208 http://www.ncbi.nlm.nih.gov/pubmed/16546208 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415039 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415039 RefSeq WP_000141275 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000141275 SMART SM00346 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00346 SMR P0ACN4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACN4 STRING 511145.b0506 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0506&targetmode=cogs STRING COG1414 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1414&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SUPFAM SSF55781 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55781 UniProtKB ALLR_ECOLI http://www.uniprot.org/uniprot/ALLR_ECOLI UniProtKB-AC P0ACN4 http://www.uniprot.org/uniprot/P0ACN4 charge swissprot:ALLR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ALLR_ECOLI eggNOG COG1414 http://eggnogapi.embl.de/nog_data/html/tree/COG1414 eggNOG ENOG4108N16 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108N16 epestfind swissprot:ALLR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ALLR_ECOLI garnier swissprot:ALLR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ALLR_ECOLI helixturnhelix swissprot:ALLR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ALLR_ECOLI hmoment swissprot:ALLR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ALLR_ECOLI iep swissprot:ALLR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ALLR_ECOLI inforesidue swissprot:ALLR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ALLR_ECOLI octanol swissprot:ALLR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ALLR_ECOLI pepcoil swissprot:ALLR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ALLR_ECOLI pepdigest swissprot:ALLR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ALLR_ECOLI pepinfo swissprot:ALLR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ALLR_ECOLI pepnet swissprot:ALLR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ALLR_ECOLI pepstats swissprot:ALLR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ALLR_ECOLI pepwheel swissprot:ALLR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ALLR_ECOLI pepwindow swissprot:ALLR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ALLR_ECOLI sigcleave swissprot:ALLR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ALLR_ECOLI ## Database ID URL or Descriptions # AltName Gamma-glutamylcysteine synthetase 2 {ECO:0000255|HAMAP-Rule MF_01609} # BioGrid 4260711 9 # CATALYTIC ACTIVITY ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine. {ECO:0000255|HAMAP- Rule MF_01609}. # EcoGene EG13644 ybdK # FUNCTION GCS2_ECOLI ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity. However, because of the low catalytic rate, the question remains whether L-cysteine is the actual biological substrate. {ECO 0000255|HAMAP-Rule MF_01609, ECO 0000269|PubMed 15211520}. # GO_function GO:0004357 glutamate-cysteine ligase activity; IEA:UniProtKB-EC. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016879 ligase activity, forming carbon-nitrogen bonds; IDA:EcoCyc. # GO_process GO:0042398 cellular modified amino acid biosynthetic process; IEA:InterPro. # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # HAMAP MF_01609 Glu_cys_ligase_2 # IntAct P77213 6 # InterPro IPR006336 GCS2 # InterPro IPR011793 YbdK # KEGG_Brite ko01000 Enzymes # MISCELLANEOUS GCS2_ECOLI Catalytic activity was tested towards all 20 common amino acids, but was only observed with L-cysteine. # Organism GCS2_ECOLI Escherichia coli (strain K12) # PATRIC 32116330 VBIEscCol129921_0605 # PDB 1R8G X-ray; 2.15 A; A/B=1-372 # PIR C64791 C64791 # Pfam PF04107 GCS2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Putative glutamate--cysteine ligase 2 {ECO:0000255|HAMAP-Rule MF_01609} # RefSeq NP_415113 NC_000913.3 # RefSeq WP_001130654 NZ_LN832404.1 # SIMILARITY Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily. {ECO:0000255|HAMAP-Rule MF_01609}. # SUBUNIT GCS2_ECOLI Homodimer. {ECO 0000255|HAMAP-Rule MF_01609, ECO 0000269|PubMed 15211520}. # TIGRFAMs TIGR02050 gshA_cyan_rel # eggNOG COG2170 LUCA # eggNOG ENOG4106KXD Bacteria BLAST swissprot:GCS2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GCS2_ECOLI BioCyc ECOL316407:JW0570-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0570-MONOMER BioCyc EcoCyc:G6326-MONOMER http://biocyc.org/getid?id=EcoCyc:G6326-MONOMER COG COG2170 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2170 DOI 10.1002/prot.20103 http://dx.doi.org/10.1002/prot.20103 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.3.2.2 {ECO:0000255|HAMAP-Rule:MF_01609} http://www.genome.jp/dbget-bin/www_bget?EC:6.3.2.2 {ECO:0000255|HAMAP-Rule:MF_01609} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 ENZYME 6.3.2.2 {ECO:0000255|HAMAP-Rule:MF_01609} http://enzyme.expasy.org/EC/6.3.2.2 {ECO:0000255|HAMAP-Rule:MF_01609} EchoBASE EB3408 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3408 EcoGene EG13644 http://www.ecogene.org/geneInfo.php?eg_id=EG13644 EnsemblBacteria AAC73682 http://www.ensemblgenomes.org/id/AAC73682 EnsemblBacteria AAC73682 http://www.ensemblgenomes.org/id/AAC73682 EnsemblBacteria BAA35221 http://www.ensemblgenomes.org/id/BAA35221 EnsemblBacteria BAA35221 http://www.ensemblgenomes.org/id/BAA35221 EnsemblBacteria BAA35221 http://www.ensemblgenomes.org/id/BAA35221 EnsemblBacteria b0581 http://www.ensemblgenomes.org/id/b0581 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004357 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004357 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016879 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016879 GO_process GO:0042398 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042398 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 947246 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947246 HAMAP MF_01609 http://hamap.expasy.org/unirule/MF_01609 HOGENOM HOG000220942 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220942&db=HOGENOM6 InParanoid P77213 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77213 IntAct P77213 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77213* IntEnz 6.3.2.2 {ECO:0000255|HAMAP-Rule:MF_01609} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.2.2 {ECO:0000255|HAMAP-Rule:MF_01609} InterPro IPR006336 http://www.ebi.ac.uk/interpro/entry/IPR006336 InterPro IPR011793 http://www.ebi.ac.uk/interpro/entry/IPR011793 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0570 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0570 KEGG_Gene eco:b0581 http://www.genome.jp/dbget-bin/www_bget?eco:b0581 KEGG_Orthology KO:K06048 http://www.genome.jp/dbget-bin/www_bget?KO:K06048 OMA AFPMSGR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AFPMSGR PDB 1R8G http://www.ebi.ac.uk/pdbe-srv/view/entry/1R8G PDBsum 1R8G http://www.ebi.ac.uk/pdbsum/1R8G PSORT swissprot:GCS2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GCS2_ECOLI PSORT-B swissprot:GCS2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GCS2_ECOLI PSORT2 swissprot:GCS2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GCS2_ECOLI Pfam PF04107 http://pfam.xfam.org/family/PF04107 Phobius swissprot:GCS2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GCS2_ECOLI PhylomeDB P77213 http://phylomedb.org/?seqid=P77213 ProteinModelPortal P77213 http://www.proteinmodelportal.org/query/uniprot/P77213 PubMed 15211520 http://www.ncbi.nlm.nih.gov/pubmed/15211520 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415113 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415113 RefSeq WP_001130654 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001130654 SMR P77213 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77213 STRING 511145.b0581 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0581&targetmode=cogs STRING COG2170 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2170&targetmode=cogs TIGRFAMs TIGR02050 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02050 UniProtKB GCS2_ECOLI http://www.uniprot.org/uniprot/GCS2_ECOLI UniProtKB-AC P77213 http://www.uniprot.org/uniprot/P77213 charge swissprot:GCS2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GCS2_ECOLI eggNOG COG2170 http://eggnogapi.embl.de/nog_data/html/tree/COG2170 eggNOG ENOG4106KXD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106KXD epestfind swissprot:GCS2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GCS2_ECOLI garnier swissprot:GCS2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GCS2_ECOLI helixturnhelix swissprot:GCS2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GCS2_ECOLI hmoment swissprot:GCS2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GCS2_ECOLI iep swissprot:GCS2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GCS2_ECOLI inforesidue swissprot:GCS2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GCS2_ECOLI octanol swissprot:GCS2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GCS2_ECOLI pepcoil swissprot:GCS2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GCS2_ECOLI pepdigest swissprot:GCS2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GCS2_ECOLI pepinfo swissprot:GCS2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GCS2_ECOLI pepnet swissprot:GCS2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GCS2_ECOLI pepstats swissprot:GCS2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GCS2_ECOLI pepwheel swissprot:GCS2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GCS2_ECOLI pepwindow swissprot:GCS2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GCS2_ECOLI sigcleave swissprot:GCS2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GCS2_ECOLI ## Database ID URL or Descriptions # BioGrid 4261070 6 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG12349 exoD # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_function GO:0004518 nuclease activity; IEA:InterPro. # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004518 nuclease activity # Gene3D 3.90.320.10 -; 1. # InterPro IPR011335 Restrct_endonuc-II-like # InterPro IPR011604 Exonuc_phg/RecB_C # MISCELLANEOUS EXOD_ECOLI Encoded by the cryptic lambdoid prophage DLP12. # Organism EXOD_ECOLI Escherichia coli (strain K12) # PATRIC 48660286 VBIEscCol107702_0535 # PIR A64786 A64786 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EXOD_ECOLI Putative uncharacterized protein ExoD # SIMILARITY To Bacteriophage lambda exonuclease exo. {ECO 0000305}. # SUPFAM SSF52980 SSF52980 BLAST swissprot:EXOD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EXOD_ECOLI BioCyc ECOL316407:JW0526-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0526-MONOMER BioCyc EcoCyc:G6295-MONOMER http://biocyc.org/getid?id=EcoCyc:G6295-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG12349 http://www.ecogene.org/geneInfo.php?eg_id=EG12349 EnsemblBacteria BAE76314 http://www.ensemblgenomes.org/id/BAE76314 EnsemblBacteria BAE76314 http://www.ensemblgenomes.org/id/BAE76314 EnsemblBacteria BAE76314 http://www.ensemblgenomes.org/id/BAE76314 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 Gene3D 3.90.320.10 http://www.cathdb.info/version/latest/superfamily/3.90.320.10 InterPro IPR011335 http://www.ebi.ac.uk/interpro/entry/IPR011335 InterPro IPR011604 http://www.ebi.ac.uk/interpro/entry/IPR011604 KEGG_Gene ecj:JW0526 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0526 PSORT swissprot:EXOD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EXOD_ECOLI PSORT-B swissprot:EXOD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EXOD_ECOLI PSORT2 swissprot:EXOD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EXOD_ECOLI Phobius swissprot:EXOD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EXOD_ECOLI ProteinModelPortal P75717 http://www.proteinmodelportal.org/query/uniprot/P75717 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SMR P75717 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75717 STRING 316407.85674674 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85674674&targetmode=cogs SUPFAM SSF52980 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52980 UniProtKB EXOD_ECOLI http://www.uniprot.org/uniprot/EXOD_ECOLI UniProtKB-AC P75717 http://www.uniprot.org/uniprot/P75717 charge swissprot:EXOD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EXOD_ECOLI epestfind swissprot:EXOD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EXOD_ECOLI garnier swissprot:EXOD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EXOD_ECOLI helixturnhelix swissprot:EXOD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EXOD_ECOLI hmoment swissprot:EXOD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EXOD_ECOLI iep swissprot:EXOD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EXOD_ECOLI inforesidue swissprot:EXOD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EXOD_ECOLI octanol swissprot:EXOD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EXOD_ECOLI pepcoil swissprot:EXOD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EXOD_ECOLI pepdigest swissprot:EXOD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EXOD_ECOLI pepinfo swissprot:EXOD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EXOD_ECOLI pepnet swissprot:EXOD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EXOD_ECOLI pepstats swissprot:EXOD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EXOD_ECOLI pepwheel swissprot:EXOD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EXOD_ECOLI pepwindow swissprot:EXOD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EXOD_ECOLI sigcleave swissprot:EXOD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EXOD_ECOLI ## Database ID URL or Descriptions # BioGrid 4263073 19 # EcoGene EG13986 yniA # GO_function GO:0016301 kinase activity; IBA:GO_Central. # GOslim_function GO:0016301 kinase activity # IntAct P77739 6 # InterPro IPR011009 Kinase-like_dom # InterPro IPR016477 Fructo-/Ketosamine-3-kinase # Organism YNIA_ECOLI Escherichia coli (strain K12) # PATRIC 32118757 VBIEscCol129921_1796 # PIR E64931 E64931 # PIRSF PIRSF006221 Ketosamine-3-kinase # Pfam PF03881 Fructosamin_kin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNIA_ECOLI Uncharacterized protein YniA # RefSeq NP_416239 NC_000913.3 # RefSeq WP_000267650 NZ_LN832404.1 # SIMILARITY Belongs to the fructosamine kinase family. {ECO 0000305}. # SUPFAM SSF56112 SSF56112 # eggNOG COG3001 LUCA # eggNOG ENOG4105FGM Bacteria BLAST swissprot:YNIA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNIA_ECOLI BioCyc ECOL316407:JW1714-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1714-MONOMER BioCyc EcoCyc:G6930-MONOMER http://biocyc.org/getid?id=EcoCyc:G6930-MONOMER DIP DIP-12775N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12775N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3742 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3742 EcoGene EG13986 http://www.ecogene.org/geneInfo.php?eg_id=EG13986 EnsemblBacteria AAC74795 http://www.ensemblgenomes.org/id/AAC74795 EnsemblBacteria AAC74795 http://www.ensemblgenomes.org/id/AAC74795 EnsemblBacteria BAA15501 http://www.ensemblgenomes.org/id/BAA15501 EnsemblBacteria BAA15501 http://www.ensemblgenomes.org/id/BAA15501 EnsemblBacteria BAA15501 http://www.ensemblgenomes.org/id/BAA15501 EnsemblBacteria b1725 http://www.ensemblgenomes.org/id/b1725 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GeneID 946236 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946236 HOGENOM HOG000023913 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000023913&db=HOGENOM6 InParanoid P77739 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77739 IntAct P77739 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77739* InterPro IPR011009 http://www.ebi.ac.uk/interpro/entry/IPR011009 InterPro IPR016477 http://www.ebi.ac.uk/interpro/entry/IPR016477 KEGG_Gene ecj:JW1714 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1714 KEGG_Gene eco:b1725 http://www.genome.jp/dbget-bin/www_bget?eco:b1725 OMA LVHLNLF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LVHLNLF PSORT swissprot:YNIA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNIA_ECOLI PSORT-B swissprot:YNIA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNIA_ECOLI PSORT2 swissprot:YNIA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNIA_ECOLI Pfam PF03881 http://pfam.xfam.org/family/PF03881 Phobius swissprot:YNIA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNIA_ECOLI PhylomeDB P77739 http://phylomedb.org/?seqid=P77739 ProteinModelPortal P77739 http://www.proteinmodelportal.org/query/uniprot/P77739 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416239 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416239 RefSeq WP_000267650 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000267650 SMR P77739 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77739 STRING 511145.b1725 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1725&targetmode=cogs SUPFAM SSF56112 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56112 UniProtKB YNIA_ECOLI http://www.uniprot.org/uniprot/YNIA_ECOLI UniProtKB-AC P77739 http://www.uniprot.org/uniprot/P77739 charge swissprot:YNIA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNIA_ECOLI eggNOG COG3001 http://eggnogapi.embl.de/nog_data/html/tree/COG3001 eggNOG ENOG4105FGM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FGM epestfind swissprot:YNIA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNIA_ECOLI garnier swissprot:YNIA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNIA_ECOLI helixturnhelix swissprot:YNIA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNIA_ECOLI hmoment swissprot:YNIA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNIA_ECOLI iep swissprot:YNIA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNIA_ECOLI inforesidue swissprot:YNIA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNIA_ECOLI octanol swissprot:YNIA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNIA_ECOLI pepcoil swissprot:YNIA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNIA_ECOLI pepdigest swissprot:YNIA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNIA_ECOLI pepinfo swissprot:YNIA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNIA_ECOLI pepnet swissprot:YNIA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNIA_ECOLI pepstats swissprot:YNIA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNIA_ECOLI pepwheel swissprot:YNIA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNIA_ECOLI pepwindow swissprot:YNIA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNIA_ECOLI sigcleave swissprot:YNIA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNIA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262192 46 # CAUTION IF3_ECOLI Was originally (PubMed 2954162) thought to control the translation of its own gene by binding to its mRNA; it now seems that discrimination against the AUU start codon is a kinetic effect (PubMed 16857585). {ECO 0000305|PubMed 16857585, ECO 0000305|PubMed 2954162}. # EcoGene EG10506 infC # FUNCTION IF3_ECOLI One of the essential components for the initiation of protein synthesis.IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. {ECO 0000269|PubMed 22562136}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0003743 translation initiation factor activity; IDA:EcoCyc. # GO_function GO:0043022 ribosome binding; IDA:EcoCyc. # GO_process GO:0009409 response to cold; IDA:EcoCyc. # GO_process GO:0032790 ribosome disassembly; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008135 translation factor activity, RNA binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # Gene3D 3.10.20.80 -; 1. # Gene3D 3.30.110.10 -; 1. # HAMAP MF_00080 IF_3 # INTERACTION IF3_ECOLI P02359 rpsG; NbExp=3; IntAct=EBI-546262, EBI-543074; # IntAct P0A707 48 # InterPro IPR001288 Translation_initiation_fac_3 # InterPro IPR019813 Translation_initiation_fac3_CS # InterPro IPR019814 Translation_initiation_fac_3_N # InterPro IPR019815 Translation_initiation_fac_3_C # KEGG_Brite ko03012 Translation factors # MISCELLANEOUS A short form called IF-3S/IF-3 beta is found both in vivo and in vitro and is probably produced by degradation of the long form IF-3L/IF-3 alpha. The major form is the N- methylmethionine long form. {ECO:0000269|PubMed 330233}. # Organism IF3_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10938 PTHR10938 # PATRIC 32118740 VBIEscCol129921_1788 # PDB 2IFE NMR; -; A=81-180 # PIR S13748 FIEC3 # PROSITE PS00938 IF3 # PTM IF3_ECOLI Phosphorylated on threonine residue(s). {ECO 0000269|PubMed 1534259}. # PTM IF3_ECOLI The form lacking the initiator methionine is less abundant than the N-methylmethionine form. {ECO 0000269|PubMed 330233}. # Pfam PF00707 IF3_C # Pfam PF05198 IF3_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Translation initiation factor IF-3 {ECO:0000255|HAMAP-Rule MF_00080} # RecName Translation initiation factor IF-3 {ECO:0000255|HAMAP-Rule MF_00080} # RecName Translation initiation factor IF-3, N-terminally processed {ECO:0000255|HAMAP-Rule MF_00080} # RecName Translation initiation factor IF-3, N-terminally processed {ECO:0000255|HAMAP-Rule MF_00080} # RecName Translation initiation factor IF-3S {ECO:0000255|HAMAP-Rule MF_00080} # RefSeq NP_416233 NC_000913.3 # RefSeq WP_001700733 NZ_LN832404.1 # SIMILARITY Belongs to the IF-3 family. {ECO:0000255|HAMAP- Rule MF_00080}. # SUBCELLULAR LOCATION IF3_ECOLI Cytoplasm {ECO 0000269|PubMed 330233}. # SUBUNIT Monomer. Component of the 30S ribosomal translation pre- initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly. {ECO:0000269|PubMed 22562136}. # SUPFAM SSF54364 SSF54364 # SUPFAM SSF55200 SSF55200 # TIGRFAMs TIGR00168 infC # eggNOG COG0290 LUCA # eggNOG ENOG4108UUX Bacteria BLAST swissprot:IF3_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:IF3_ECOLI BioCyc ECOL316407:JW5829-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5829-MONOMER BioCyc EcoCyc:EG10506-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10506-MONOMER COG COG0290 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0290 DIP DIP-36176N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36176N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/jmbi.1996.0756 http://dx.doi.org/10.1006/jmbi.1996.0756 DOI 10.1006/jmbi.1998.1736 http://dx.doi.org/10.1006/jmbi.1998.1736 DOI 10.1016/0014-5793(77)80800-4 http://dx.doi.org/10.1016/0014-5793(77)80800-4 DOI 10.1016/0014-5793(77)80801-6 http://dx.doi.org/10.1016/0014-5793(77)80801-6 DOI 10.1016/0300-9084(91)90141-M http://dx.doi.org/10.1016/0300-9084(91)90141-M DOI 10.1016/j.molcel.2006.05.030 http://dx.doi.org/10.1016/j.molcel.2006.05.030 DOI 10.1021/bi00135a012 http://dx.doi.org/10.1021/bi00135a012 DOI 10.1021/bi00163a005 http://dx.doi.org/10.1021/bi00163a005 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsmb.2285 http://dx.doi.org/10.1038/nsmb.2285 DOI 10.1073/pnas.84.12.4022 http://dx.doi.org/10.1073/pnas.84.12.4022 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1111/j.1432-1033.1995.00395.x http://dx.doi.org/10.1111/j.1432-1033.1995.00395.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pbio.1001095 http://dx.doi.org/10.1371/journal.pbio.1001095 DOI 10.3109/10409238.2012.678284 http://dx.doi.org/10.3109/10409238.2012.678284 DisProt DP00197 http://www.disprot.org/protein.php?id=DP00197 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K02844 http://www.ebi.ac.uk/ena/data/view/K02844 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00291 http://www.ebi.ac.uk/ena/data/view/V00291 EchoBASE EB0501 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0501 EcoGene EG10506 http://www.ecogene.org/geneInfo.php?eg_id=EG10506 EnsemblBacteria AAC74788 http://www.ensemblgenomes.org/id/AAC74788 EnsemblBacteria AAC74788 http://www.ensemblgenomes.org/id/AAC74788 EnsemblBacteria BAA15485 http://www.ensemblgenomes.org/id/BAA15485 EnsemblBacteria BAA15485 http://www.ensemblgenomes.org/id/BAA15485 EnsemblBacteria BAA15485 http://www.ensemblgenomes.org/id/BAA15485 EnsemblBacteria b1718 http://www.ensemblgenomes.org/id/b1718 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0003743 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003743 GO_function GO:0043022 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043022 GO_process GO:0009409 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009409 GO_process GO:0032790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032790 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008135 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008135 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.10.20.80 http://www.cathdb.info/version/latest/superfamily/3.10.20.80 Gene3D 3.30.110.10 http://www.cathdb.info/version/latest/superfamily/3.30.110.10 GeneID 946225 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946225 HAMAP MF_00080 http://hamap.expasy.org/unirule/MF_00080 HOGENOM HOG000035157 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000035157&db=HOGENOM6 InParanoid P0A707 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A707 IntAct P0A707 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A707* InterPro IPR001288 http://www.ebi.ac.uk/interpro/entry/IPR001288 InterPro IPR019813 http://www.ebi.ac.uk/interpro/entry/IPR019813 InterPro IPR019814 http://www.ebi.ac.uk/interpro/entry/IPR019814 InterPro IPR019815 http://www.ebi.ac.uk/interpro/entry/IPR019815 KEGG_Brite ko03012 http://www.genome.jp/dbget-bin/www_bget?ko03012 KEGG_Gene ecj:JW5829 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5829 KEGG_Gene eco:b1718 http://www.genome.jp/dbget-bin/www_bget?eco:b1718 KEGG_Orthology KO:K02520 http://www.genome.jp/dbget-bin/www_bget?KO:K02520 MINT MINT-1221578 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1221578 OMA HDFNVKV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HDFNVKV PANTHER PTHR10938 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10938 PDB 2IFE http://www.ebi.ac.uk/pdbe-srv/view/entry/2IFE PDBsum 2IFE http://www.ebi.ac.uk/pdbsum/2IFE PROSITE PS00938 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00938 PSORT swissprot:IF3_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:IF3_ECOLI PSORT-B swissprot:IF3_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:IF3_ECOLI PSORT2 swissprot:IF3_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:IF3_ECOLI Pfam PF00707 http://pfam.xfam.org/family/PF00707 Pfam PF05198 http://pfam.xfam.org/family/PF05198 Phobius swissprot:IF3_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:IF3_ECOLI PhylomeDB P0A707 http://phylomedb.org/?seqid=P0A707 ProteinModelPortal P0A707 http://www.proteinmodelportal.org/query/uniprot/P0A707 PubMed 1457399 http://www.ncbi.nlm.nih.gov/pubmed/1457399 PubMed 1534259 http://www.ncbi.nlm.nih.gov/pubmed/1534259 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16857585 http://www.ncbi.nlm.nih.gov/pubmed/16857585 PubMed 1742345 http://www.ncbi.nlm.nih.gov/pubmed/1742345 PubMed 21750663 http://www.ncbi.nlm.nih.gov/pubmed/21750663 PubMed 22515367 http://www.ncbi.nlm.nih.gov/pubmed/22515367 PubMed 22562136 http://www.ncbi.nlm.nih.gov/pubmed/22562136 PubMed 2954162 http://www.ncbi.nlm.nih.gov/pubmed/2954162 PubMed 330232 http://www.ncbi.nlm.nih.gov/pubmed/330232 PubMed 330233 http://www.ncbi.nlm.nih.gov/pubmed/330233 PubMed 6325158 http://www.ncbi.nlm.nih.gov/pubmed/6325158 PubMed 7705354 http://www.ncbi.nlm.nih.gov/pubmed/7705354 PubMed 9054966 http://www.ncbi.nlm.nih.gov/pubmed/9054966 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9614948 http://www.ncbi.nlm.nih.gov/pubmed/9614948 RefSeq NP_416233 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416233 RefSeq WP_001700733 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001700733 SMR P0A707 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A707 STRING 511145.b1718 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1718&targetmode=cogs STRING COG0290 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0290&targetmode=cogs SUPFAM SSF54364 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54364 SUPFAM SSF55200 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55200 TIGRFAMs TIGR00168 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00168 UniProtKB IF3_ECOLI http://www.uniprot.org/uniprot/IF3_ECOLI UniProtKB-AC P0A707 http://www.uniprot.org/uniprot/P0A707 charge swissprot:IF3_ECOLI http://rest.g-language.org/emboss/charge/swissprot:IF3_ECOLI eggNOG COG0290 http://eggnogapi.embl.de/nog_data/html/tree/COG0290 eggNOG ENOG4108UUX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UUX epestfind swissprot:IF3_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:IF3_ECOLI garnier swissprot:IF3_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:IF3_ECOLI helixturnhelix swissprot:IF3_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:IF3_ECOLI hmoment swissprot:IF3_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:IF3_ECOLI iep swissprot:IF3_ECOLI http://rest.g-language.org/emboss/iep/swissprot:IF3_ECOLI inforesidue swissprot:IF3_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:IF3_ECOLI octanol swissprot:IF3_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:IF3_ECOLI pepcoil swissprot:IF3_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:IF3_ECOLI pepdigest swissprot:IF3_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:IF3_ECOLI pepinfo swissprot:IF3_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:IF3_ECOLI pepnet swissprot:IF3_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:IF3_ECOLI pepstats swissprot:IF3_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:IF3_ECOLI pepwheel swissprot:IF3_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:IF3_ECOLI pepwindow swissprot:IF3_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:IF3_ECOLI sigcleave swissprot:IF3_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:IF3_ECOLI ## Database ID URL or Descriptions # BioGrid 4259624 201 # EcoGene EG12946 yhhZ # GO_function GO:0004519 endonuclease activity; IEA:InterPro. # GOslim_function GO:0004518 nuclease activity # Gene3D 2.30.110.20 -; 1. # InterPro IPR008514 T6SS_Hcp # InterPro IPR024622 Colicin/pyocin_DNase_dom # Organism YHHZ_ECOLI Escherichia coli (strain K12) # PATRIC 32122324 VBIEscCol129921_3539 # PIR E65140 E65140 # Pfam PF05638 T6SS_HCP # Pfam PF12639 Colicin-DNase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHHZ_ECOLI Uncharacterized protein YhhZ # RefSeq NP_417899 NC_000913.3 # RefSeq WP_000065894 NZ_LN832404.1 # SIMILARITY Belongs to the hcp1 family. {ECO 0000305}. # SUPFAM SSF141452 SSF141452 # TIGRFAMs TIGR03344 VI_effect_Hcp1 # eggNOG COG3157 LUCA # eggNOG ENOG4105GMB Bacteria BLAST swissprot:YHHZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHHZ_ECOLI BioCyc ECOL316407:JW3406-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3406-MONOMER BioCyc EcoCyc:G7759-MONOMER http://biocyc.org/getid?id=EcoCyc:G7759-MONOMER COG COG3157 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3157 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2780 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2780 EcoGene EG12946 http://www.ecogene.org/geneInfo.php?eg_id=EG12946 EnsemblBacteria AAC76467 http://www.ensemblgenomes.org/id/AAC76467 EnsemblBacteria AAC76467 http://www.ensemblgenomes.org/id/AAC76467 EnsemblBacteria BAE77851 http://www.ensemblgenomes.org/id/BAE77851 EnsemblBacteria BAE77851 http://www.ensemblgenomes.org/id/BAE77851 EnsemblBacteria BAE77851 http://www.ensemblgenomes.org/id/BAE77851 EnsemblBacteria b3442 http://www.ensemblgenomes.org/id/b3442 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004519 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004519 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 Gene3D 2.30.110.20 http://www.cathdb.info/version/latest/superfamily/2.30.110.20 GeneID 947952 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947952 HOGENOM HOG000125642 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125642&db=HOGENOM6 InterPro IPR008514 http://www.ebi.ac.uk/interpro/entry/IPR008514 InterPro IPR024622 http://www.ebi.ac.uk/interpro/entry/IPR024622 KEGG_Gene ecj:JW3406 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3406 KEGG_Gene eco:b3442 http://www.genome.jp/dbget-bin/www_bget?eco:b3442 KEGG_Orthology KO:K06887 http://www.genome.jp/dbget-bin/www_bget?KO:K06887 OMA LPENYNC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LPENYNC PSORT swissprot:YHHZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHHZ_ECOLI PSORT-B swissprot:YHHZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHHZ_ECOLI PSORT2 swissprot:YHHZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHHZ_ECOLI Pfam PF05638 http://pfam.xfam.org/family/PF05638 Pfam PF12639 http://pfam.xfam.org/family/PF12639 Phobius swissprot:YHHZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHHZ_ECOLI ProteinModelPortal P46855 http://www.proteinmodelportal.org/query/uniprot/P46855 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417899 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417899 RefSeq WP_000065894 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000065894 SMR P46855 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P46855 STRING 511145.b3442 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3442&targetmode=cogs STRING COG3157 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3157&targetmode=cogs SUPFAM SSF141452 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF141452 TIGRFAMs TIGR03344 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03344 UniProtKB YHHZ_ECOLI http://www.uniprot.org/uniprot/YHHZ_ECOLI UniProtKB-AC P46855 http://www.uniprot.org/uniprot/P46855 charge swissprot:YHHZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHHZ_ECOLI eggNOG COG3157 http://eggnogapi.embl.de/nog_data/html/tree/COG3157 eggNOG ENOG4105GMB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105GMB epestfind swissprot:YHHZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHHZ_ECOLI garnier swissprot:YHHZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHHZ_ECOLI helixturnhelix swissprot:YHHZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHHZ_ECOLI hmoment swissprot:YHHZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHHZ_ECOLI iep swissprot:YHHZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHHZ_ECOLI inforesidue swissprot:YHHZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHHZ_ECOLI octanol swissprot:YHHZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHHZ_ECOLI pepcoil swissprot:YHHZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHHZ_ECOLI pepdigest swissprot:YHHZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHHZ_ECOLI pepinfo swissprot:YHHZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHHZ_ECOLI pepnet swissprot:YHHZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHHZ_ECOLI pepstats swissprot:YHHZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHHZ_ECOLI pepwheel swissprot:YHHZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHHZ_ECOLI pepwindow swissprot:YHHZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHHZ_ECOLI sigcleave swissprot:YHHZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHHZ_ECOLI ## Database ID URL or Descriptions # BioGrid 4261911 353 # EcoGene EG13439 lolC # FUNCTION LOLC_ECOLI Part of an ATP-dependent transport system LolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and of LolA. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0043234 protein complex; IDA:EcoCyc. # GO_function GO:0042954 lipoprotein transporter activity; IDA:EcoCyc. # GO_process GO:0042953 lipoprotein transport; IDA:EcoCyc. # GO_process GO:0089705 protein localization to outer membrane; IMP:CACAO. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006810 transport # GOslim_process GO:0061024 membrane organization # InterPro IPR003838 ABC_permease_dom # InterPro IPR011925 LolCE_TM # InterPro IPR025857 MacB_PCD # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00255 Lipoprotein-releasing system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism LOLC_ECOLI Escherichia coli (strain K12) # PATRIC 32117479 VBIEscCol129921_1162 # PIR A64856 A64856 # Pfam PF02687 FtsX # Pfam PF12704 MacB_PCD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LOLC_ECOLI Lipoprotein-releasing system transmembrane protein LolC # RefSeq NP_415634 NC_000913.3 # RefSeq WP_000284714 NZ_LN832404.1 # SIMILARITY Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION LOLC_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 3.A.1.125 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR02212 lolCE # eggNOG COG4591 LUCA # eggNOG ENOG4105D60 Bacteria BLAST swissprot:LOLC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LOLC_ECOLI BioCyc ECOL316407:JW5161-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5161-MONOMER BioCyc EcoCyc:YCFU-MONOMER http://biocyc.org/getid?id=EcoCyc:YCFU-MONOMER COG COG4591 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4591 DIP DIP-58651N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-58651N DOI 10.1038/35008635 http://dx.doi.org/10.1038/35008635 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3213 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3213 EcoGene EG13439 http://www.ecogene.org/geneInfo.php?eg_id=EG13439 EnsemblBacteria AAC74200 http://www.ensemblgenomes.org/id/AAC74200 EnsemblBacteria AAC74200 http://www.ensemblgenomes.org/id/AAC74200 EnsemblBacteria BAA35936 http://www.ensemblgenomes.org/id/BAA35936 EnsemblBacteria BAA35936 http://www.ensemblgenomes.org/id/BAA35936 EnsemblBacteria BAA35936 http://www.ensemblgenomes.org/id/BAA35936 EnsemblBacteria b1116 http://www.ensemblgenomes.org/id/b1116 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GO_function GO:0042954 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042954 GO_process GO:0042953 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042953 GO_process GO:0089705 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0089705 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0061024 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024 GeneID 945673 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945673 HOGENOM HOG000218040 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218040&db=HOGENOM6 InParanoid P0ADC3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADC3 InterPro IPR003838 http://www.ebi.ac.uk/interpro/entry/IPR003838 InterPro IPR011925 http://www.ebi.ac.uk/interpro/entry/IPR011925 InterPro IPR025857 http://www.ebi.ac.uk/interpro/entry/IPR025857 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5161 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5161 KEGG_Gene eco:b1116 http://www.genome.jp/dbget-bin/www_bget?eco:b1116 KEGG_Orthology KO:K09808 http://www.genome.jp/dbget-bin/www_bget?KO:K09808 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA YVKHVTF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YVKHVTF PSORT swissprot:LOLC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LOLC_ECOLI PSORT-B swissprot:LOLC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LOLC_ECOLI PSORT2 swissprot:LOLC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LOLC_ECOLI Pfam PF02687 http://pfam.xfam.org/family/PF02687 Pfam PF12704 http://pfam.xfam.org/family/PF12704 Phobius swissprot:LOLC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LOLC_ECOLI PhylomeDB P0ADC3 http://phylomedb.org/?seqid=P0ADC3 ProteinModelPortal P0ADC3 http://www.proteinmodelportal.org/query/uniprot/P0ADC3 PubMed 10783239 http://www.ncbi.nlm.nih.gov/pubmed/10783239 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415634 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415634 RefSeq WP_000284714 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000284714 STRING 511145.b1116 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1116&targetmode=cogs STRING COG4591 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4591&targetmode=cogs TCDB 3.A.1.125 http://www.tcdb.org/search/result.php?tc=3.A.1.125 TIGRFAMs TIGR02212 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02212 UniProtKB LOLC_ECOLI http://www.uniprot.org/uniprot/LOLC_ECOLI UniProtKB-AC P0ADC3 http://www.uniprot.org/uniprot/P0ADC3 charge swissprot:LOLC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LOLC_ECOLI eggNOG COG4591 http://eggnogapi.embl.de/nog_data/html/tree/COG4591 eggNOG ENOG4105D60 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D60 epestfind swissprot:LOLC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LOLC_ECOLI garnier swissprot:LOLC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LOLC_ECOLI helixturnhelix swissprot:LOLC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LOLC_ECOLI hmoment swissprot:LOLC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LOLC_ECOLI iep swissprot:LOLC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LOLC_ECOLI inforesidue swissprot:LOLC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LOLC_ECOLI octanol swissprot:LOLC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LOLC_ECOLI pepcoil swissprot:LOLC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LOLC_ECOLI pepdigest swissprot:LOLC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LOLC_ECOLI pepinfo swissprot:LOLC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LOLC_ECOLI pepnet swissprot:LOLC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LOLC_ECOLI pepstats swissprot:LOLC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LOLC_ECOLI pepwheel swissprot:LOLC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LOLC_ECOLI pepwindow swissprot:LOLC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LOLC_ECOLI sigcleave swissprot:LOLC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LOLC_ECOLI ## Database ID URL or Descriptions # AltName KDSC_ECOLI KDO 8-P phosphatase # BIOPHYSICOCHEMICAL PROPERTIES pH dependence: Optimum pH is 5.5 (at pH 7.5 and 37 degrees Celsius). {ECO 0000269|PubMed:12639950}; # BioGrid 4261882 244 # CATALYTIC ACTIVITY 3-deoxy-D-manno-octulosonate 8-phosphate + H(2)O = 3-deoxy-D-manno-octulosonate + phosphate. {ECO:0000269|PubMed 12639950}. # COFACTOR KDSC_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 12639950}; Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000269|PubMed 12639950}; Note=Mg(2+). The phosphatase activity is also stimulated by cobalt ions, whereas baryum, zinc, and manganese ions are less effective stimulators. {ECO 0000269|PubMed 12639950}; # ENZYME REGULATION Inhibited by calcium, cadmium, mercury, and copper ions. {ECO:0000269|PubMed 12639950}. # EcoGene EG12804 kdsC # FUNCTION KDSC_ECOLI Involved in the biosynthesis of lipopolysaccharides (LPSs), but is not essential (PubMed 16765569). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate (PubMed 12639950, PubMed 16765569). {ECO 0000269|PubMed 12639950, ECO 0000269|PubMed 16765569}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008781 N-acylneuraminate cytidylyltransferase activity; IBA:GO_Central. # GO_function GO:0019143 3-deoxy-manno-octulosonate-8-phosphatase activity; IEA:UniProtKB-EC. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IMP:UniProtKB. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.1000 -; 1. # IntAct P0ABZ4 2 # InterPro IPR010023 KDO_8-P_phosphatase # InterPro IPR023214 HAD-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # KEGG_Pathway ko00540 Lipopolysaccharide biosynthesis # MASS SPECTROMETRY Mass=19881; Method=Electrospray; Range=2-188; Evidence={ECO:0000269|PubMed 12639950}; # Organism KDSC_ECOLI Escherichia coli (strain K12) # PATHWAY Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5- phosphate step 3/3. # PATHWAY KDSC_ECOLI Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. # PATRIC 32121816 VBIEscCol129921_3292 # PIR H65110 H65110 # PIRSF PIRSF006118 KDO8-P_Ptase # Pfam PF08282 Hydrolase_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName KDSC_ECOLI 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC # RefSeq NP_417665 NC_000913.3 # RefSeq WP_000030005 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA57999.1; Type=Frameshift; Positions=116; Evidence={ECO:0000305}; Sequence=AAA58000.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=AAA58000.1; Type=Frameshift; Positions=116; Evidence={ECO:0000305}; # SIMILARITY Belongs to the KdsC family. {ECO 0000305}. # SUBUNIT Homotetramer. {ECO:0000269|PubMed 12639950}. # SUPFAM SSF56784 SSF56784 # TIGRFAMs TIGR01670 KdsC-phosphatas # UniPathway UPA00357 UER00475 # eggNOG COG1778 LUCA # eggNOG ENOG4108Z4R Bacteria BLAST swissprot:KDSC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:KDSC_ECOLI BioCyc ECOL316407:JW3165-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3165-MONOMER BioCyc EcoCyc:G7663-MONOMER http://biocyc.org/getid?id=EcoCyc:G7663-MONOMER COG COG1778 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1778 DIP DIP-48034N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48034N DOI 10.1016/j.resmic.2005.11.014 http://dx.doi.org/10.1016/j.resmic.2005.11.014 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M301983200 http://dx.doi.org/10.1074/jbc.M301983200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.3.45 {ECO:0000269|PubMed:16765569} http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.45 {ECO:0000269|PubMed:16765569} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 3.1.3.45 {ECO:0000269|PubMed:16765569} http://enzyme.expasy.org/EC/3.1.3.45 {ECO:0000269|PubMed:16765569} EchoBASE EB2656 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2656 EcoGene EG12804 http://www.ecogene.org/geneInfo.php?eg_id=EG12804 EnsemblBacteria AAC76230 http://www.ensemblgenomes.org/id/AAC76230 EnsemblBacteria AAC76230 http://www.ensemblgenomes.org/id/AAC76230 EnsemblBacteria BAE77242 http://www.ensemblgenomes.org/id/BAE77242 EnsemblBacteria BAE77242 http://www.ensemblgenomes.org/id/BAE77242 EnsemblBacteria BAE77242 http://www.ensemblgenomes.org/id/BAE77242 EnsemblBacteria b3198 http://www.ensemblgenomes.org/id/b3198 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008781 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008781 GO_function GO:0019143 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019143 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.1000 http://www.cathdb.info/version/latest/superfamily/3.40.50.1000 GeneID 947717 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947717 HOGENOM HOG000264740 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000264740&db=HOGENOM6 InParanoid P0ABZ4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABZ4 IntAct P0ABZ4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABZ4* IntEnz 3.1.3.45 {ECO:0000269|PubMed:16765569} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.45 {ECO:0000269|PubMed:16765569} InterPro IPR010023 http://www.ebi.ac.uk/interpro/entry/IPR010023 InterPro IPR023214 http://www.ebi.ac.uk/interpro/entry/IPR023214 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Gene ecj:JW3165 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3165 KEGG_Gene eco:b3198 http://www.genome.jp/dbget-bin/www_bget?eco:b3198 KEGG_Orthology KO:K03270 http://www.genome.jp/dbget-bin/www_bget?KO:K03270 KEGG_Pathway ko00540 http://www.genome.jp/kegg-bin/show_pathway?ko00540 KEGG_Reaction rn:R03350 http://www.genome.jp/dbget-bin/www_bget?rn:R03350 OMA FDENFHE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FDENFHE PSORT swissprot:KDSC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:KDSC_ECOLI PSORT-B swissprot:KDSC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:KDSC_ECOLI PSORT2 swissprot:KDSC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:KDSC_ECOLI Pfam PF08282 http://pfam.xfam.org/family/PF08282 Phobius swissprot:KDSC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:KDSC_ECOLI PhylomeDB P0ABZ4 http://phylomedb.org/?seqid=P0ABZ4 ProteinModelPortal P0ABZ4 http://www.proteinmodelportal.org/query/uniprot/P0ABZ4 PubMed 12639950 http://www.ncbi.nlm.nih.gov/pubmed/12639950 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16765569 http://www.ncbi.nlm.nih.gov/pubmed/16765569 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417665 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417665 RefSeq WP_000030005 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000030005 SMR P0ABZ4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABZ4 STRING 511145.b3198 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3198&targetmode=cogs STRING COG1778 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1778&targetmode=cogs SUPFAM SSF56784 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784 TIGRFAMs TIGR01670 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01670 UniProtKB KDSC_ECOLI http://www.uniprot.org/uniprot/KDSC_ECOLI UniProtKB-AC P0ABZ4 http://www.uniprot.org/uniprot/P0ABZ4 charge swissprot:KDSC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:KDSC_ECOLI eggNOG COG1778 http://eggnogapi.embl.de/nog_data/html/tree/COG1778 eggNOG ENOG4108Z4R http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Z4R epestfind swissprot:KDSC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:KDSC_ECOLI garnier swissprot:KDSC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:KDSC_ECOLI helixturnhelix swissprot:KDSC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:KDSC_ECOLI hmoment swissprot:KDSC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:KDSC_ECOLI iep swissprot:KDSC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:KDSC_ECOLI inforesidue swissprot:KDSC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:KDSC_ECOLI octanol swissprot:KDSC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:KDSC_ECOLI pepcoil swissprot:KDSC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:KDSC_ECOLI pepdigest swissprot:KDSC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:KDSC_ECOLI pepinfo swissprot:KDSC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:KDSC_ECOLI pepnet swissprot:KDSC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:KDSC_ECOLI pepstats swissprot:KDSC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:KDSC_ECOLI pepwheel swissprot:KDSC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:KDSC_ECOLI pepwindow swissprot:KDSC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:KDSC_ECOLI sigcleave swissprot:KDSC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:KDSC_ECOLI ## Database ID URL or Descriptions # AltName NANC_ECOLI NanR-regulated channel # AltName NANC_ECOLI Porin NanC # BioGrid 4259375 217 # EcoGene EG12389 nanC # FUNCTION NANC_ECOLI Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria (Probable). NanC proteins form high-conductance channels which are open at low membrane potentials and which have a weak anion selectivity. {ECO 0000269|PubMed 15743943, ECO 0000305}. # GO_component GO:0045203 integral component of cell outer membrane; IDA:EcoliWiki. # GO_component GO:0046930 pore complex; IEA:UniProtKB-KW. # GO_function GO:0015136 sialic acid transmembrane transporter activity; IMP:EcoliWiki. # GO_function GO:0015288 porin activity; IMP:EcoliWiki. # GO_function GO:0015478 oligosaccharide transporting porin activity; IMP:EcoliWiki. # GO_process GO:0006811 ion transport; IEA:UniProtKB-KW. # GO_process GO:0015772 oligosaccharide transport; IMP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043234 protein complex # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # INDUCTION Induced by N-acetylneuraminate and modulated by N- acetylglucosamine. This regulation occurs via the NanR and NagC regulators. NanC expression is also activated by the regulators cyclic AMP-catabolite activator protein, OmpR, and CpxR. {ECO:0000269|PubMed 15743943}. # InterPro IPR009331 Oligogalacturonate-sp_porin # Organism NANC_ECOLI Escherichia coli (strain K12) # PATRIC 32124216 VBIEscCol129921_4451 # PDB 2WJQ X-ray; 2.00 A; A=24-238 # PDB 2WJR X-ray; 1.80 A; A=25-238 # PIR S56536 S56536 # Pfam PF06178 KdgM # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NANC_ECOLI Probable N-acetylneuraminic acid outer membrane channel protein NanC # RefSeq NP_418731 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA97207.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the oligogalacturonate-specific porin KdgM (TC 1.B.35) family. NanC subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION NANC_ECOLI Cell outer membrane. # SUBUNIT Monomer. {ECO:0000269|PubMed 19796645}. # TCDB 1.B.35.2 the oligogalacturonate-specific porin (kdgm) family # eggNOG ENOG41069FU Bacteria # eggNOG ENOG410XY8U LUCA BLAST swissprot:NANC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NANC_ECOLI BioCyc ECOL316407:JW5778-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5778-MONOMER BioCyc EcoCyc:G7921-MONOMER http://biocyc.org/getid?id=EcoCyc:G7921-MONOMER BioCyc MetaCyc:G7921-MONOMER http://biocyc.org/getid?id=MetaCyc:G7921-MONOMER DOI 10.1016/j.jmb.2009.09.054 http://dx.doi.org/10.1016/j.jmb.2009.09.054 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.187.6.1959-1965.2005 http://dx.doi.org/10.1128/JB.187.6.1959-1965.2005 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2290 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2290 EcoGene EG12389 http://www.ecogene.org/geneInfo.php?eg_id=EG12389 EnsemblBacteria AAC77267 http://www.ensemblgenomes.org/id/AAC77267 EnsemblBacteria AAC77267 http://www.ensemblgenomes.org/id/AAC77267 EnsemblBacteria BAE78304 http://www.ensemblgenomes.org/id/BAE78304 EnsemblBacteria BAE78304 http://www.ensemblgenomes.org/id/BAE78304 EnsemblBacteria BAE78304 http://www.ensemblgenomes.org/id/BAE78304 EnsemblBacteria b4311 http://www.ensemblgenomes.org/id/b4311 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0045203 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045203 GO_component GO:0046930 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046930 GO_function GO:0015136 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015136 GO_function GO:0015288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015288 GO_function GO:0015478 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015478 GO_process GO:0006811 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811 GO_process GO:0015772 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015772 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 946843 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946843 HOGENOM HOG000127485 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000127485&db=HOGENOM6 InterPro IPR009331 http://www.ebi.ac.uk/interpro/entry/IPR009331 KEGG_Gene ecj:JW5778 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5778 KEGG_Gene eco:b4311 http://www.genome.jp/dbget-bin/www_bget?eco:b4311 OMA GEDNISE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GEDNISE PDB 2WJQ http://www.ebi.ac.uk/pdbe-srv/view/entry/2WJQ PDB 2WJR http://www.ebi.ac.uk/pdbe-srv/view/entry/2WJR PDBsum 2WJQ http://www.ebi.ac.uk/pdbsum/2WJQ PDBsum 2WJR http://www.ebi.ac.uk/pdbsum/2WJR PSORT swissprot:NANC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NANC_ECOLI PSORT-B swissprot:NANC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NANC_ECOLI PSORT2 swissprot:NANC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NANC_ECOLI Pfam PF06178 http://pfam.xfam.org/family/PF06178 Phobius swissprot:NANC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NANC_ECOLI ProteinModelPortal P69856 http://www.proteinmodelportal.org/query/uniprot/P69856 PubMed 15743943 http://www.ncbi.nlm.nih.gov/pubmed/15743943 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19796645 http://www.ncbi.nlm.nih.gov/pubmed/19796645 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418731 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418731 SMR P69856 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69856 STRING 511145.b4311 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4311&targetmode=cogs TCDB 1.B.35.2 http://www.tcdb.org/search/result.php?tc=1.B.35.2 UniProtKB NANC_ECOLI http://www.uniprot.org/uniprot/NANC_ECOLI UniProtKB-AC P69856 http://www.uniprot.org/uniprot/P69856 charge swissprot:NANC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NANC_ECOLI eggNOG ENOG41069FU http://eggnogapi.embl.de/nog_data/html/tree/ENOG41069FU eggNOG ENOG410XY8U http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XY8U epestfind swissprot:NANC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NANC_ECOLI garnier swissprot:NANC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NANC_ECOLI helixturnhelix swissprot:NANC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NANC_ECOLI hmoment swissprot:NANC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NANC_ECOLI iep swissprot:NANC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NANC_ECOLI inforesidue swissprot:NANC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NANC_ECOLI octanol swissprot:NANC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NANC_ECOLI pepcoil swissprot:NANC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NANC_ECOLI pepdigest swissprot:NANC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NANC_ECOLI pepinfo swissprot:NANC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NANC_ECOLI pepnet swissprot:NANC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NANC_ECOLI pepstats swissprot:NANC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NANC_ECOLI pepwheel swissprot:NANC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NANC_ECOLI pepwindow swissprot:NANC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NANC_ECOLI sigcleave swissprot:NANC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NANC_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES ACCD_ECOLI Kinetic parameters KM=40.0 uM for malonyl-CoA {ECO 0000269|PubMed 15066985, ECO 0000269|PubMed 19965770}; KM=11.4 mM for biocytin {ECO 0000269|PubMed 15066985, ECO 0000269|PubMed 19965770}; # BioGrid 4261361 233 # CATALYTIC ACTIVITY ATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoA. {ECO:0000255|HAMAP-Rule MF_01395}. # COFACTOR ACCD_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000255|HAMAP-Rule MF_01395, ECO 0000269|PubMed 19965770}; Note=Binds 1 zinc ion per subunit. The zinc is involved in both translation regulation via mRNA-binding and catalysis. {ECO 0000255|HAMAP-Rule MF_01395, ECO 0000269|PubMed 19965770}; # ENZYME REGULATION Competitively inhibited by pyrrolidine dione antibiotic moiramide B (CPD1). {ECO:0000269|PubMed 15066985}. # EcoGene EG10217 accD # FUNCTION ACCD_ECOLI Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA. # FUNCTION ACCD_ECOLI Controls translation of mRNA for both itself and the alpha-subunit (accA) by binding to a probable hairpin in the 5' of the mRNA. Binding to mRNA inhibits translation; this is partially relieved by acetyl-CoA. Increasing amounts of mRNA also inhibit enzyme activity. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0009329 acetate CoA-transferase complex; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IMP:EcoCyc. # GO_function GO:0003729 mRNA binding; IDA:EcoCyc. # GO_function GO:0003989 acetyl-CoA carboxylase activity; IDA:EcoliWiki. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_process GO:0006633 fatty acid biosynthetic process; IMP:EcoCyc. # GO_process GO:0017148 negative regulation of translation; IDA:EcoCyc. # GO_process GO:0042759 long-chain fatty acid biosynthetic process; NAS:EcoliWiki. # GO_process GO:2001295 malonyl-CoA biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0003729 mRNA binding # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.90.226.10 -; 1. # HAMAP MF_01395 AcetylCoA_CT_beta # INTERACTION ACCD_ECOLI P0ABD5 accA; NbExp=14; IntAct=EBI-542064, EBI-542031; # IntAct P0A9Q5 28 # InterPro IPR000022 Carboxyl_trans # InterPro IPR000438 Acetyl_CoA_COase_Trfase_b_su # InterPro IPR011762 COA_CT_N # InterPro IPR029045 ClpP/crotonase-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00061 Fatty acid biosynthesis # KEGG_Pathway ko00253 Tetracycline biosynthesis # KEGG_Pathway ko00620 Pyruvate metabolism # KEGG_Pathway ko00640 Propanoate metabolism # KEGG_Pathway ko00720 Carbon fixation pathways in prokaryotes # Organism ACCD_ECOLI Escherichia coli (strain K12) # PATHWAY Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. {ECO 0000255|HAMAP-Rule:MF_01395}. # PATRIC 32120003 VBIEscCol129921_2411 # PDB 2F9Y X-ray; 3.20 A; B=1-304 # PIR B65004 XMECBD # PRINTS PR01070 ACCCTRFRASEB # PROSITE PS50980 COA_CT_NTER # Pfam PF01039 Carboxyl_trans # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta {ECO:0000255|HAMAP-Rule MF_01395} # RefSeq NP_416819 NC_000913.3 # RefSeq WP_000118404 NZ_LN832404.1 # SIMILARITY Belongs to the AccD/PCCB family. {ECO:0000255|HAMAP- Rule MF_01395}. # SIMILARITY Contains 1 CoA carboxyltransferase N-terminal domain. {ECO:0000255|PROSITE-ProRule PRU01136}. # SUBCELLULAR LOCATION ACCD_ECOLI Cytoplasm. # SUBUNIT ACCD_ECOLI Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD). # SUPFAM SSF52096 SSF52096 # TIGRFAMs TIGR00515 accD # UniPathway UPA00655 UER00711 # eggNOG COG0777 LUCA # eggNOG ENOG4108IDZ Bacteria BLAST swissprot:ACCD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ACCD_ECOLI BioCyc ECOL316407:JW2313-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2313-MONOMER BioCyc EcoCyc:CARBOXYL-TRANSFERASE-BETA-MONOMER http://biocyc.org/getid?id=EcoCyc:CARBOXYL-TRANSFERASE-BETA-MONOMER BioCyc MetaCyc:CARBOXYL-TRANSFERASE-BETA-MONOMER http://biocyc.org/getid?id=MetaCyc:CARBOXYL-TRANSFERASE-BETA-MONOMER COG COG0777 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0777 DIP DIP-35878N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35878N DOI 10.1007/BF00282448 http://dx.doi.org/10.1007/BF00282448 DOI 10.1021/bi0520479 http://dx.doi.org/10.1021/bi0520479 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M402989200 http://dx.doi.org/10.1074/jbc.M402989200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/nar/gkp1079 http://dx.doi.org/10.1093/nar/gkp1079 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.4.1.2 {ECO:0000255|HAMAP-Rule:MF_01395} http://www.genome.jp/dbget-bin/www_bget?EC:6.4.1.2 {ECO:0000255|HAMAP-Rule:MF_01395} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J02808 http://www.ebi.ac.uk/ena/data/view/J02808 EMBL M32445 http://www.ebi.ac.uk/ena/data/view/M32445 EMBL M68934 http://www.ebi.ac.uk/ena/data/view/M68934 EMBL S53037 http://www.ebi.ac.uk/ena/data/view/S53037 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 6.4.1.2 {ECO:0000255|HAMAP-Rule:MF_01395} http://enzyme.expasy.org/EC/6.4.1.2 {ECO:0000255|HAMAP-Rule:MF_01395} EchoBASE EB0213 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0213 EcoGene EG10217 http://www.ecogene.org/geneInfo.php?eg_id=EG10217 EnsemblBacteria AAC75376 http://www.ensemblgenomes.org/id/AAC75376 EnsemblBacteria AAC75376 http://www.ensemblgenomes.org/id/AAC75376 EnsemblBacteria BAA16173 http://www.ensemblgenomes.org/id/BAA16173 EnsemblBacteria BAA16173 http://www.ensemblgenomes.org/id/BAA16173 EnsemblBacteria BAA16173 http://www.ensemblgenomes.org/id/BAA16173 EnsemblBacteria b2316 http://www.ensemblgenomes.org/id/b2316 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0009329 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009329 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003729 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003729 GO_function GO:0003989 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003989 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_process GO:0006633 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006633 GO_process GO:0017148 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017148 GO_process GO:0042759 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042759 GO_process GO:2001295 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2001295 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0003729 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003729 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.90.226.10 http://www.cathdb.info/version/latest/superfamily/3.90.226.10 GeneID 946796 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946796 HAMAP MF_01395 http://hamap.expasy.org/unirule/MF_01395 HOGENOM HOG000021670 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000021670&db=HOGENOM6 InParanoid P0A9Q5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9Q5 IntAct P0A9Q5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9Q5* IntEnz 6.4.1.2 {ECO:0000255|HAMAP-Rule:MF_01395} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.4.1.2 {ECO:0000255|HAMAP-Rule:MF_01395} InterPro IPR000022 http://www.ebi.ac.uk/interpro/entry/IPR000022 InterPro IPR000438 http://www.ebi.ac.uk/interpro/entry/IPR000438 InterPro IPR011762 http://www.ebi.ac.uk/interpro/entry/IPR011762 InterPro IPR029045 http://www.ebi.ac.uk/interpro/entry/IPR029045 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2313 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2313 KEGG_Gene eco:b2316 http://www.genome.jp/dbget-bin/www_bget?eco:b2316 KEGG_Orthology KO:K01963 http://www.genome.jp/dbget-bin/www_bget?KO:K01963 KEGG_Pathway ko00061 http://www.genome.jp/kegg-bin/show_pathway?ko00061 KEGG_Pathway ko00253 http://www.genome.jp/kegg-bin/show_pathway?ko00253 KEGG_Pathway ko00620 http://www.genome.jp/kegg-bin/show_pathway?ko00620 KEGG_Pathway ko00640 http://www.genome.jp/kegg-bin/show_pathway?ko00640 KEGG_Pathway ko00720 http://www.genome.jp/kegg-bin/show_pathway?ko00720 KEGG_Reaction rn:R00742 http://www.genome.jp/dbget-bin/www_bget?rn:R00742 KEGG_Reaction rn:R04386 http://www.genome.jp/dbget-bin/www_bget?rn:R04386 MINT MINT-1234646 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1234646 OMA PEGLWIK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PEGLWIK PDB 2F9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/2F9Y PDBsum 2F9Y http://www.ebi.ac.uk/pdbsum/2F9Y PRINTS PR01070 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01070 PROSITE PS50980 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50980 PSORT swissprot:ACCD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ACCD_ECOLI PSORT-B swissprot:ACCD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ACCD_ECOLI PSORT2 swissprot:ACCD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ACCD_ECOLI Pfam PF01039 http://pfam.xfam.org/family/PF01039 Phobius swissprot:ACCD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ACCD_ECOLI PhylomeDB P0A9Q5 http://phylomedb.org/?seqid=P0A9Q5 ProteinModelPortal P0A9Q5 http://www.proteinmodelportal.org/query/uniprot/P0A9Q5 PubMed 1355086 http://www.ncbi.nlm.nih.gov/pubmed/1355086 PubMed 15066985 http://www.ncbi.nlm.nih.gov/pubmed/15066985 PubMed 16460018 http://www.ncbi.nlm.nih.gov/pubmed/16460018 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1886618 http://www.ncbi.nlm.nih.gov/pubmed/1886618 PubMed 19965770 http://www.ncbi.nlm.nih.gov/pubmed/19965770 PubMed 3040734 http://www.ncbi.nlm.nih.gov/pubmed/3040734 PubMed 3040739 http://www.ncbi.nlm.nih.gov/pubmed/3040739 PubMed 7678242 http://www.ncbi.nlm.nih.gov/pubmed/7678242 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416819 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416819 RefSeq WP_000118404 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000118404 SMR P0A9Q5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9Q5 STRING 511145.b2316 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2316&targetmode=cogs STRING COG0777 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0777&targetmode=cogs SUPFAM SSF52096 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52096 TIGRFAMs TIGR00515 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00515 UniProtKB ACCD_ECOLI http://www.uniprot.org/uniprot/ACCD_ECOLI UniProtKB-AC P0A9Q5 http://www.uniprot.org/uniprot/P0A9Q5 charge swissprot:ACCD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ACCD_ECOLI eggNOG COG0777 http://eggnogapi.embl.de/nog_data/html/tree/COG0777 eggNOG ENOG4108IDZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108IDZ epestfind swissprot:ACCD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ACCD_ECOLI garnier swissprot:ACCD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ACCD_ECOLI helixturnhelix swissprot:ACCD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ACCD_ECOLI hmoment swissprot:ACCD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ACCD_ECOLI iep swissprot:ACCD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ACCD_ECOLI inforesidue swissprot:ACCD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ACCD_ECOLI octanol swissprot:ACCD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ACCD_ECOLI pepcoil swissprot:ACCD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ACCD_ECOLI pepdigest swissprot:ACCD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ACCD_ECOLI pepinfo swissprot:ACCD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ACCD_ECOLI pepnet swissprot:ACCD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ACCD_ECOLI pepstats swissprot:ACCD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ACCD_ECOLI pepwheel swissprot:ACCD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ACCD_ECOLI pepwindow swissprot:ACCD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ACCD_ECOLI sigcleave swissprot:ACCD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ACCD_ECOLI ## Database ID URL or Descriptions # AltName KTHY_ECOLI Thymidine monophosphate kinase # AltName KTHY_ECOLI dTMP kinase # BIOPHYSICOCHEMICAL PROPERTIES KTHY_ECOLI Kinetic parameters KM=0.04 mM for ATP (at pH 7.4 and 30 degrees Celsius) {ECO 0000269|PubMed 11369858}; KM=15 uM for dTMP (at pH 7.4 and 30 degrees Celsius) {ECO 0000269|PubMed 11369858}; Vmax=50 umol/min/mg enzyme with ATP and dTMP as substrates (at pH 7.4 and 30 degrees Celsius) {ECO 0000269|PubMed 11369858}; # BioGrid 4263411 36 # CATALYTIC ACTIVITY KTHY_ECOLI ATP + dTMP = ADP + dTDP. # DOMAIN KTHY_ECOLI The LID domain is a solvent-exposed domain that closes over the site of phosphoryl transfer upon ATP binding. # EcoGene EG12302 tmk # FUNCTION KTHY_ECOLI Catalyzes the reversible phosphorylation of deoxythymidine monophosphate (dTMP) to deoxythymidine diphosphate (dTDP), using ATP as its preferred phosphoryl donor. Situated at the junction of both de novo and salvage pathways of deoxythymidine triphosphate (dTTP) synthesis, is essential for DNA synthesis and cellular growth. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004798 thymidylate kinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0009041 uridylate kinase activity; IBA:GO_Central. # GO_process GO:0006227 dUDP biosynthetic process; IBA:GO_Central. # GO_process GO:0006233 dTDP biosynthetic process; IDA:EcoliWiki. # GO_process GO:0006235 dTTP biosynthetic process; IDA:EcoliWiki. # GO_process GO:0015949 nucleobase-containing small molecule interconversion; IDA:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.300 -; 1. # HAMAP MF_00165 Thymidylate_kinase # IntAct P0A720 8 # InterPro IPR018094 Thymidylate_kinase # InterPro IPR018095 Thymidylate_kin_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00240 Pyrimidine metabolism # Organism KTHY_ECOLI Escherichia coli (strain K12) # PATHWAY KTHY_ECOLI Pyrimidine metabolism; dTTP biosynthesis. # PATRIC 32117437 VBIEscCol129921_1141 # PDB 1E9F X-ray; 1.90 A; A=151-156 # PDB 4TMK X-ray; 1.98 A; A=1-213 # PDB 5TMP X-ray; 1.98 A; A=1-213 # PIR JC6006 G64853 # PROSITE PS01331 THYMIDYLATE_KINASE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName KTHY_ECOLI Thymidylate kinase # RefSeq NP_415616 NC_000913.3 # RefSeq WP_001257000 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=L01483; Type=Frameshift; Positions=92, 136; Evidence={ECO 0000305}; # SIMILARITY Belongs to the thymidylate kinase family. {ECO 0000305}. # SUBUNIT KTHY_ECOLI Homodimer. # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR00041 DTMP_kinase # eggNOG COG0125 LUCA # eggNOG ENOG4108ZMD Bacteria BLAST swissprot:KTHY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:KTHY_ECOLI BioCyc ECOL316407:JW1084-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1084-MONOMER BioCyc EcoCyc:DTMPKI-MONOMER http://biocyc.org/getid?id=EcoCyc:DTMPKI-MONOMER BioCyc MetaCyc:DTMPKI-MONOMER http://biocyc.org/getid?id=MetaCyc:DTMPKI-MONOMER COG COG0125 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0125 DIP DIP-48110N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48110N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.95.24.14045 http://dx.doi.org/10.1073/pnas.95.24.14045 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1110/ps.45701 http://dx.doi.org/10.1110/ps.45701 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.4.9 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.4.9 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L01483 http://www.ebi.ac.uk/ena/data/view/L01483 EMBL L04577 http://www.ebi.ac.uk/ena/data/view/L04577 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U41456 http://www.ebi.ac.uk/ena/data/view/U41456 ENZYME 2.7.4.9 http://enzyme.expasy.org/EC/2.7.4.9 EchoBASE EB2208 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2208 EcoGene EG12302 http://www.ecogene.org/geneInfo.php?eg_id=EG12302 EnsemblBacteria AAC74182 http://www.ensemblgenomes.org/id/AAC74182 EnsemblBacteria AAC74182 http://www.ensemblgenomes.org/id/AAC74182 EnsemblBacteria BAA35905 http://www.ensemblgenomes.org/id/BAA35905 EnsemblBacteria BAA35905 http://www.ensemblgenomes.org/id/BAA35905 EnsemblBacteria BAA35905 http://www.ensemblgenomes.org/id/BAA35905 EnsemblBacteria b1098 http://www.ensemblgenomes.org/id/b1098 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004798 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0009041 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009041 GO_process GO:0006227 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006227 GO_process GO:0006233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006233 GO_process GO:0006235 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006235 GO_process GO:0015949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015949 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945663 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945663 HAMAP MF_00165 http://hamap.expasy.org/unirule/MF_00165 HOGENOM HOG000229078 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000229078&db=HOGENOM6 InParanoid P0A720 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A720 IntAct P0A720 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A720* IntEnz 2.7.4.9 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.4.9 InterPro IPR018094 http://www.ebi.ac.uk/interpro/entry/IPR018094 InterPro IPR018095 http://www.ebi.ac.uk/interpro/entry/IPR018095 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1084 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1084 KEGG_Gene eco:b1098 http://www.genome.jp/dbget-bin/www_bget?eco:b1098 KEGG_Orthology KO:K00943 http://www.genome.jp/dbget-bin/www_bget?KO:K00943 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Reaction rn:R02094 http://www.genome.jp/dbget-bin/www_bget?rn:R02094 KEGG_Reaction rn:R02098 http://www.genome.jp/dbget-bin/www_bget?rn:R02098 MINT MINT-1258134 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1258134 OMA GGIDIAE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GGIDIAE PDB 1E9F http://www.ebi.ac.uk/pdbe-srv/view/entry/1E9F PDB 4TMK http://www.ebi.ac.uk/pdbe-srv/view/entry/4TMK PDB 5TMP http://www.ebi.ac.uk/pdbe-srv/view/entry/5TMP PDBsum 1E9F http://www.ebi.ac.uk/pdbsum/1E9F PDBsum 4TMK http://www.ebi.ac.uk/pdbsum/4TMK PDBsum 5TMP http://www.ebi.ac.uk/pdbsum/5TMP PROSITE PS01331 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01331 PSORT swissprot:KTHY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:KTHY_ECOLI PSORT-B swissprot:KTHY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:KTHY_ECOLI PSORT2 swissprot:KTHY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:KTHY_ECOLI Phobius swissprot:KTHY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:KTHY_ECOLI PhylomeDB P0A720 http://phylomedb.org/?seqid=P0A720 ProteinModelPortal P0A720 http://www.proteinmodelportal.org/query/uniprot/P0A720 PubMed 11369858 http://www.ncbi.nlm.nih.gov/pubmed/11369858 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8505303 http://www.ncbi.nlm.nih.gov/pubmed/8505303 PubMed 8509334 http://www.ncbi.nlm.nih.gov/pubmed/8509334 PubMed 8631667 http://www.ncbi.nlm.nih.gov/pubmed/8631667 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9826650 http://www.ncbi.nlm.nih.gov/pubmed/9826650 RefSeq NP_415616 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415616 RefSeq WP_001257000 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001257000 SMR P0A720 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A720 STRING 511145.b1098 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1098&targetmode=cogs STRING COG0125 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0125&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR00041 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00041 UniProtKB KTHY_ECOLI http://www.uniprot.org/uniprot/KTHY_ECOLI UniProtKB-AC P0A720 http://www.uniprot.org/uniprot/P0A720 charge swissprot:KTHY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:KTHY_ECOLI eggNOG COG0125 http://eggnogapi.embl.de/nog_data/html/tree/COG0125 eggNOG ENOG4108ZMD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZMD epestfind swissprot:KTHY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:KTHY_ECOLI garnier swissprot:KTHY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:KTHY_ECOLI helixturnhelix swissprot:KTHY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:KTHY_ECOLI hmoment swissprot:KTHY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:KTHY_ECOLI iep swissprot:KTHY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:KTHY_ECOLI inforesidue swissprot:KTHY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:KTHY_ECOLI octanol swissprot:KTHY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:KTHY_ECOLI pepcoil swissprot:KTHY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:KTHY_ECOLI pepdigest swissprot:KTHY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:KTHY_ECOLI pepinfo swissprot:KTHY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:KTHY_ECOLI pepnet swissprot:KTHY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:KTHY_ECOLI pepstats swissprot:KTHY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:KTHY_ECOLI pepwheel swissprot:KTHY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:KTHY_ECOLI pepwindow swissprot:KTHY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:KTHY_ECOLI sigcleave swissprot:KTHY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:KTHY_ECOLI ## Database ID URL or Descriptions # BioGrid 4259350 8 # EcoGene EG11244 yggE # GO_component GO:0071575 integral component of external side of plasma membrane; IDA:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoCyc. # GO_process GO:0034605 cellular response to heat; IEP:EcoCyc. # GO_process GO:0034614 cellular response to reactive oxygen species; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0006950 response to stress # IntAct P0ADS6 8 # InterPro IPR007497 DUF541 # Organism YGGE_ECOLI Escherichia coli (strain K12) # PATRIC 32121258 VBIEscCol129921_3017 # PIR A65077 A65077 # Pfam PF04402 SIMPL # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGGE_ECOLI Uncharacterized protein YggE # RefSeq NP_417397 NC_000913.3 # RefSeq WP_000669834 NZ_LN832404.1 # eggNOG COG2968 LUCA # eggNOG ENOG4105MPN Bacteria BLAST swissprot:YGGE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGGE_ECOLI BioCyc ECOL316407:JW2889-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2889-MONOMER BioCyc EcoCyc:EG11244-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11244-MONOMER COG COG2968 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2968 DIP DIP-47891N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47891N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1989.tb00221.x http://dx.doi.org/10.1111/j.1365-2958.1989.tb00221.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EMBL X14436 http://www.ebi.ac.uk/ena/data/view/X14436 EchoBASE EB1225 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1225 EcoGene EG11244 http://www.ecogene.org/geneInfo.php?eg_id=EG11244 EnsemblBacteria AAC75959 http://www.ensemblgenomes.org/id/AAC75959 EnsemblBacteria AAC75959 http://www.ensemblgenomes.org/id/AAC75959 EnsemblBacteria BAE76986 http://www.ensemblgenomes.org/id/BAE76986 EnsemblBacteria BAE76986 http://www.ensemblgenomes.org/id/BAE76986 EnsemblBacteria BAE76986 http://www.ensemblgenomes.org/id/BAE76986 EnsemblBacteria b2922 http://www.ensemblgenomes.org/id/b2922 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0071575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071575 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0034605 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034605 GO_process GO:0034614 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034614 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 947398 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947398 HOGENOM HOG000279581 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000279581&db=HOGENOM6 InParanoid P0ADS6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADS6 IntAct P0ADS6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADS6* InterPro IPR007497 http://www.ebi.ac.uk/interpro/entry/IPR007497 KEGG_Gene ecj:JW2889 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2889 KEGG_Gene eco:b2922 http://www.genome.jp/dbget-bin/www_bget?eco:b2922 KEGG_Orthology KO:K09807 http://www.genome.jp/dbget-bin/www_bget?KO:K09807 OMA LPNGPHI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LPNGPHI PSORT swissprot:YGGE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGGE_ECOLI PSORT-B swissprot:YGGE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGGE_ECOLI PSORT2 swissprot:YGGE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGGE_ECOLI Pfam PF04402 http://pfam.xfam.org/family/PF04402 Phobius swissprot:YGGE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGGE_ECOLI PhylomeDB P0ADS6 http://phylomedb.org/?seqid=P0ADS6 ProteinModelPortal P0ADS6 http://www.proteinmodelportal.org/query/uniprot/P0ADS6 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2546007 http://www.ncbi.nlm.nih.gov/pubmed/2546007 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417397 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417397 RefSeq WP_000669834 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000669834 SMR P0ADS6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADS6 STRING 511145.b2922 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2922&targetmode=cogs STRING COG2968 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2968&targetmode=cogs UniProtKB YGGE_ECOLI http://www.uniprot.org/uniprot/YGGE_ECOLI UniProtKB-AC P0ADS6 http://www.uniprot.org/uniprot/P0ADS6 charge swissprot:YGGE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGGE_ECOLI eggNOG COG2968 http://eggnogapi.embl.de/nog_data/html/tree/COG2968 eggNOG ENOG4105MPN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105MPN epestfind swissprot:YGGE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGGE_ECOLI garnier swissprot:YGGE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGGE_ECOLI helixturnhelix swissprot:YGGE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGGE_ECOLI hmoment swissprot:YGGE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGGE_ECOLI iep swissprot:YGGE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGGE_ECOLI inforesidue swissprot:YGGE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGGE_ECOLI octanol swissprot:YGGE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGGE_ECOLI pepcoil swissprot:YGGE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGGE_ECOLI pepdigest swissprot:YGGE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGGE_ECOLI pepinfo swissprot:YGGE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGGE_ECOLI pepnet swissprot:YGGE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGGE_ECOLI pepstats swissprot:YGGE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGGE_ECOLI pepwheel swissprot:YGGE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGGE_ECOLI pepwindow swissprot:YGGE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGGE_ECOLI sigcleave swissprot:YGGE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGGE_ECOLI ## Database ID URL or Descriptions # BioGrid 4262490 7 # EcoGene EG12220 yhhT # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0005215 transporter activity; IBA:GO_Central. # GO_process GO:0055085 transmembrane transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0055085 transmembrane transport # InterPro IPR002549 AI-2E-like # Organism YHHT_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21716 PTHR21716 # PATRIC 32122392 VBIEscCol129921_3573 # PIR S47693 S47693 # Pfam PF01594 AI-2E_transport # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHHT_ECOLI UPF0118 inner membrane protein YhhT # RefSeq NP_417931 NC_000913.3 # RefSeq WP_001300885 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18449.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the UPF0118 (PerM) family. {ECO 0000305}. # SUBCELLULAR LOCATION YHHT_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.86.1 the autoinducer-2 exporter (ai-2e) family (formerly the perm family, tc #9.b.22) # eggNOG COG0628 LUCA # eggNOG ENOG4105DSF Bacteria BLAST swissprot:YHHT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHHT_ECOLI BioCyc ECOL316407:JW5680-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5680-MONOMER BioCyc EcoCyc:EG12220-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12220-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2134 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2134 EcoGene EG12220 http://www.ecogene.org/geneInfo.php?eg_id=EG12220 EnsemblBacteria AAC76499 http://www.ensemblgenomes.org/id/AAC76499 EnsemblBacteria AAC76499 http://www.ensemblgenomes.org/id/AAC76499 EnsemblBacteria BAE77819 http://www.ensemblgenomes.org/id/BAE77819 EnsemblBacteria BAE77819 http://www.ensemblgenomes.org/id/BAE77819 EnsemblBacteria BAE77819 http://www.ensemblgenomes.org/id/BAE77819 EnsemblBacteria b3474 http://www.ensemblgenomes.org/id/b3474 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 947980 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947980 HOGENOM HOG000290196 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000290196&db=HOGENOM6 InParanoid P0AGM0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGM0 InterPro IPR002549 http://www.ebi.ac.uk/interpro/entry/IPR002549 KEGG_Gene ecj:JW5680 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5680 KEGG_Gene eco:b3474 http://www.genome.jp/dbget-bin/www_bget?eco:b3474 OMA IDNIPRY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IDNIPRY PANTHER PTHR21716 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21716 PSORT swissprot:YHHT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHHT_ECOLI PSORT-B swissprot:YHHT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHHT_ECOLI PSORT2 swissprot:YHHT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHHT_ECOLI Pfam PF01594 http://pfam.xfam.org/family/PF01594 Phobius swissprot:YHHT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHHT_ECOLI PhylomeDB P0AGM0 http://phylomedb.org/?seqid=P0AGM0 ProteinModelPortal P0AGM0 http://www.proteinmodelportal.org/query/uniprot/P0AGM0 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417931 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417931 RefSeq WP_001300885 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300885 STRING 511145.b3474 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3474&targetmode=cogs TCDB 2.A.86.1 http://www.tcdb.org/search/result.php?tc=2.A.86.1 UniProtKB YHHT_ECOLI http://www.uniprot.org/uniprot/YHHT_ECOLI UniProtKB-AC P0AGM0 http://www.uniprot.org/uniprot/P0AGM0 charge swissprot:YHHT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHHT_ECOLI eggNOG COG0628 http://eggnogapi.embl.de/nog_data/html/tree/COG0628 eggNOG ENOG4105DSF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DSF epestfind swissprot:YHHT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHHT_ECOLI garnier swissprot:YHHT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHHT_ECOLI helixturnhelix swissprot:YHHT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHHT_ECOLI hmoment swissprot:YHHT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHHT_ECOLI iep swissprot:YHHT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHHT_ECOLI inforesidue swissprot:YHHT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHHT_ECOLI octanol swissprot:YHHT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHHT_ECOLI pepcoil swissprot:YHHT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHHT_ECOLI pepdigest swissprot:YHHT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHHT_ECOLI pepinfo swissprot:YHHT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHHT_ECOLI pepnet swissprot:YHHT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHHT_ECOLI pepstats swissprot:YHHT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHHT_ECOLI pepwheel swissprot:YHHT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHHT_ECOLI pepwindow swissprot:YHHT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHHT_ECOLI sigcleave swissprot:YHHT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHHT_ECOLI ## Database ID URL or Descriptions # BioGrid 4262943 9 # EcoGene EG12323 yfaD # IntAct P37014 3 # InterPro IPR006842 Transposase_31 # InterPro IPR010106 CHP01784 # Organism YFAD_ECOLI Escherichia coli (strain K12) # PATRIC 32119849 VBIEscCol129921_2334 # PIR B64995 B64995 # Pfam PF04754 Transposase_31 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFAD_ECOLI Uncharacterized protein YfaD # RefSeq NP_416747 NC_000913.3 # RefSeq WP_000140592 NZ_LN832404.1 # SIMILARITY Belongs to the YadD/YfaD/YhgA/YjiP family. {ECO 0000305}. # TIGRFAMs TIGR01784 T_den_put_tspse # eggNOG COG5464 LUCA # eggNOG ENOG4105DNE Bacteria BLAST swissprot:YFAD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFAD_ECOLI BioCyc ECOL316407:JW2238-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2238-MONOMER BioCyc EcoCyc:EG12323-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12323-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M20938 http://www.ebi.ac.uk/ena/data/view/M20938 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2228 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2228 EcoGene EG12323 http://www.ecogene.org/geneInfo.php?eg_id=EG12323 EnsemblBacteria AAC75304 http://www.ensemblgenomes.org/id/AAC75304 EnsemblBacteria AAC75304 http://www.ensemblgenomes.org/id/AAC75304 EnsemblBacteria BAA16063 http://www.ensemblgenomes.org/id/BAA16063 EnsemblBacteria BAA16063 http://www.ensemblgenomes.org/id/BAA16063 EnsemblBacteria BAA16063 http://www.ensemblgenomes.org/id/BAA16063 EnsemblBacteria b2244 http://www.ensemblgenomes.org/id/b2244 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946737 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946737 HOGENOM HOG000116866 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000116866&db=HOGENOM6 InParanoid P37014 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37014 IntAct P37014 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37014* InterPro IPR006842 http://www.ebi.ac.uk/interpro/entry/IPR006842 InterPro IPR010106 http://www.ebi.ac.uk/interpro/entry/IPR010106 KEGG_Gene ecj:JW2238 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2238 KEGG_Gene eco:b2244 http://www.genome.jp/dbget-bin/www_bget?eco:b2244 OMA DIAVECK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DIAVECK PSORT swissprot:YFAD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFAD_ECOLI PSORT-B swissprot:YFAD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFAD_ECOLI PSORT2 swissprot:YFAD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFAD_ECOLI Pfam PF04754 http://pfam.xfam.org/family/PF04754 Phobius swissprot:YFAD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFAD_ECOLI PhylomeDB P37014 http://phylomedb.org/?seqid=P37014 ProteinModelPortal P37014 http://www.proteinmodelportal.org/query/uniprot/P37014 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3286606 http://www.ncbi.nlm.nih.gov/pubmed/3286606 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416747 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416747 RefSeq WP_000140592 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000140592 STRING 511145.b2244 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2244&targetmode=cogs TIGRFAMs TIGR01784 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01784 UniProtKB YFAD_ECOLI http://www.uniprot.org/uniprot/YFAD_ECOLI UniProtKB-AC P37014 http://www.uniprot.org/uniprot/P37014 charge swissprot:YFAD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFAD_ECOLI eggNOG COG5464 http://eggnogapi.embl.de/nog_data/html/tree/COG5464 eggNOG ENOG4105DNE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DNE epestfind swissprot:YFAD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFAD_ECOLI garnier swissprot:YFAD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFAD_ECOLI helixturnhelix swissprot:YFAD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFAD_ECOLI hmoment swissprot:YFAD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFAD_ECOLI iep swissprot:YFAD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFAD_ECOLI inforesidue swissprot:YFAD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFAD_ECOLI octanol swissprot:YFAD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFAD_ECOLI pepcoil swissprot:YFAD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFAD_ECOLI pepdigest swissprot:YFAD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFAD_ECOLI pepinfo swissprot:YFAD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFAD_ECOLI pepnet swissprot:YFAD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFAD_ECOLI pepstats swissprot:YFAD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFAD_ECOLI pepwheel swissprot:YFAD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFAD_ECOLI pepwindow swissprot:YFAD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFAD_ECOLI sigcleave swissprot:YFAD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFAD_ECOLI ## Database ID URL or Descriptions # AltName Haloacid dehalogenase-like phosphatase 4 {ECO:0000303|PubMed 25484615} # AltName YIHX_ECOLI Alpha-D-glucose-1-phosphatase # BIOPHYSICOCHEMICAL PROPERTIES YIHX_ECOLI Kinetic parameters KM=0.028 mM for imido-di-P (with magnesium ions as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; KM=0.24 mM for alpha-D-glucose-1-phosphate (with magnesium ions as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; KM=1.6 mM for alpha-fructose-1-phosphate (with manganese ions as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; KM=3.6 mM for acetyl-phosphate (with magnesium ions as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; Note=kcat is 10.2 sec(-1) with alpha-Glc-1-P as substrate. kcat is 1.26 sec(-1) with alpha-Man-1-P as substrate. kcat is 0.98 sec(-1) with alpha-Gal-1-P as substrate. kcat is 0.09 sec(-1) with Glc-6-P as substrate (at pH 7.0 and 37 degrees Celsius). {ECO 0000269|PubMed 25484615}; pH dependence Optimum pH is 5.0-7.0. {ECO 0000269|PubMed 16990279, ECO 0000269|PubMed 25484615}; Temperature dependence Optimum temperature is 40 degrees Celsius. {ECO 0000269|PubMed 25484615}; # BIOTECHNOLOGY Is proposed to be a useful catalyst for hydrolytic transformation (e.g. removal) of alpha-Glc-1-P from complex substrate solutions containing multiple sugar phosphates. {ECO:0000305|PubMed 25484615}. # BioGrid 4260964 8 # CATALYTIC ACTIVITY YIHX_ECOLI Alpha-D-glucose 1-phosphate + H(2)O = D- glucose + phosphate. {ECO 0000269|PubMed 16990279, ECO 0000269|PubMed 25484615}. # COFACTOR YIHX_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 16990279}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 16990279}; Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000269|PubMed 16990279}; Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 16990279}; Note=Magnesium. Can also use other divalent metal cations such as manganese, cobalt or zinc. {ECO 0000269|PubMed 16990279}; # EcoGene EG11850 yihX # FUNCTION YIHX_ECOLI Catalyzes the dephosphorylation of alpha-D-glucose 1- phosphate (Glc1P) and, to a lesser extent, of other sugar phosphates (PubMed 16990279) (PubMed 25484615). Has no activity with the beta form of Glc1P. In addition, YihX has significant phosphatase activity against pyridoxal phosphate (PLP) and low beta-phosphoglucomutase activity (PubMed 16990279). {ECO 0000269|PubMed 16990279, ECO 0000269|PubMed 25484615}. # GO_function GO:0000287 magnesium ion binding; IDA:UniProtKB. # GO_function GO:0008877 glucose-1-phosphatase activity; IDA:EcoliWiki. # GO_function GO:0030145 manganese ion binding; IDA:UniProtKB. # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0043167 ion binding # Gene3D 1.10.150.240 -; 1. # Gene3D 3.40.50.1000 -; 2. # InterPro IPR006439 HAD-SF_hydro_IA # InterPro IPR023198 PGP_dom2 # InterPro IPR023214 HAD-like_dom # Organism YIHX_ECOLI Escherichia coli (strain K12) # PATRIC 32123273 VBIEscCol129921_3997 # PDB 2B0C X-ray; 2.00 A; A=1-199 # PIR S40829 S40829 # PRINTS PR00413 HADHALOGNASE # Pfam PF13419 HAD_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIHX_ECOLI Alpha-D-glucose 1-phosphate phosphatase YihX # RefSeq NP_418321 NC_000913.3 # RefSeq WP_001295269 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB03018.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the HAD-like hydrolase superfamily. YihX family. {ECO 0000305}. # SUPFAM SSF56784 SSF56784 # TIGRFAMs TIGR01509 HAD-SF-IA-v3 # eggNOG COG1011 LUCA # eggNOG ENOG4105EJU Bacteria BLAST swissprot:YIHX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIHX_ECOLI BioCyc ECOL316407:JW5566-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5566-MONOMER BioCyc EcoCyc:EG11850-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11850-MONOMER BioCyc MetaCyc:EG11850-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11850-MONOMER COG COG1011 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1011 DIP DIP-47896N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47896N DOI 10.1016/j.fmrre.2004.12.006 http://dx.doi.org/10.1016/j.fmrre.2004.12.006 DOI 10.1016/j.molcatb.2014.09.004 http://dx.doi.org/10.1016/j.molcatb.2014.09.004 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M605449200 http://dx.doi.org/10.1074/jbc.M605449200 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.3.10 {ECO:0000269|PubMed:16990279, ECO:0000269|PubMed:25484615} http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.10 {ECO:0000269|PubMed:16990279, ECO:0000269|PubMed:25484615} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.3.10 {ECO:0000269|PubMed:16990279, ECO:0000269|PubMed:25484615} http://enzyme.expasy.org/EC/3.1.3.10 {ECO:0000269|PubMed:16990279, ECO:0000269|PubMed:25484615} EchoBASE EB1796 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1796 EcoGene EG11850 http://www.ecogene.org/geneInfo.php?eg_id=EG11850 EnsemblBacteria AAD13447 http://www.ensemblgenomes.org/id/AAD13447 EnsemblBacteria AAD13447 http://www.ensemblgenomes.org/id/AAD13447 EnsemblBacteria BAE77424 http://www.ensemblgenomes.org/id/BAE77424 EnsemblBacteria BAE77424 http://www.ensemblgenomes.org/id/BAE77424 EnsemblBacteria BAE77424 http://www.ensemblgenomes.org/id/BAE77424 EnsemblBacteria b3885 http://www.ensemblgenomes.org/id/b3885 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0008877 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008877 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 1.10.150.240 http://www.cathdb.info/version/latest/superfamily/1.10.150.240 Gene3D 3.40.50.1000 http://www.cathdb.info/version/latest/superfamily/3.40.50.1000 GeneID 948380 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948380 HOGENOM HOG000025211 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000025211&db=HOGENOM6 InParanoid P0A8Y3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8Y3 IntEnz 3.1.3.10 {ECO:0000269|PubMed:16990279, ECO:0000269|PubMed:25484615} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.10 {ECO:0000269|PubMed:16990279, ECO:0000269|PubMed:25484615} InterPro IPR006439 http://www.ebi.ac.uk/interpro/entry/IPR006439 InterPro IPR023198 http://www.ebi.ac.uk/interpro/entry/IPR023198 InterPro IPR023214 http://www.ebi.ac.uk/interpro/entry/IPR023214 KEGG_Gene ecj:JW5566 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5566 KEGG_Gene eco:b3885 http://www.genome.jp/dbget-bin/www_bget?eco:b3885 KEGG_Orthology KO:K07025 http://www.genome.jp/dbget-bin/www_bget?KO:K07025 OMA TQYPDVQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TQYPDVQ PDB 2B0C http://www.ebi.ac.uk/pdbe-srv/view/entry/2B0C PDBsum 2B0C http://www.ebi.ac.uk/pdbsum/2B0C PRINTS PR00413 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00413 PSORT swissprot:YIHX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIHX_ECOLI PSORT-B swissprot:YIHX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIHX_ECOLI PSORT2 swissprot:YIHX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIHX_ECOLI Pfam PF13419 http://pfam.xfam.org/family/PF13419 Phobius swissprot:YIHX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIHX_ECOLI PhylomeDB P0A8Y3 http://phylomedb.org/?seqid=P0A8Y3 ProteinModelPortal P0A8Y3 http://www.proteinmodelportal.org/query/uniprot/P0A8Y3 PubMed 15808744 http://www.ncbi.nlm.nih.gov/pubmed/15808744 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16990279 http://www.ncbi.nlm.nih.gov/pubmed/16990279 PubMed 25484615 http://www.ncbi.nlm.nih.gov/pubmed/25484615 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418321 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418321 RefSeq WP_001295269 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295269 SMR P0A8Y3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8Y3 STRING 511145.b3885 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3885&targetmode=cogs STRING COG1011 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1011&targetmode=cogs SUPFAM SSF56784 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784 TIGRFAMs TIGR01509 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01509 UniProtKB YIHX_ECOLI http://www.uniprot.org/uniprot/YIHX_ECOLI UniProtKB-AC P0A8Y3 http://www.uniprot.org/uniprot/P0A8Y3 charge swissprot:YIHX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIHX_ECOLI eggNOG COG1011 http://eggnogapi.embl.de/nog_data/html/tree/COG1011 eggNOG ENOG4105EJU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EJU epestfind swissprot:YIHX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIHX_ECOLI garnier swissprot:YIHX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIHX_ECOLI helixturnhelix swissprot:YIHX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIHX_ECOLI hmoment swissprot:YIHX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIHX_ECOLI iep swissprot:YIHX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIHX_ECOLI inforesidue swissprot:YIHX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIHX_ECOLI octanol swissprot:YIHX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIHX_ECOLI pepcoil swissprot:YIHX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIHX_ECOLI pepdigest swissprot:YIHX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIHX_ECOLI pepinfo swissprot:YIHX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIHX_ECOLI pepnet swissprot:YIHX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIHX_ECOLI pepstats swissprot:YIHX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIHX_ECOLI pepwheel swissprot:YIHX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIHX_ECOLI pepwindow swissprot:YIHX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIHX_ECOLI sigcleave swissprot:YIHX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIHX_ECOLI ## Database ID URL or Descriptions # BRENDA 3.1.4 2026 # BRENDA 3.1.4.16 2026 # BioGrid 4260515 360 # COFACTOR YFCE_ECOLI Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 15808744}; Note=Binds 2 manganese ions per subunit. {ECO 0000269|PubMed 15808744}; # EcoGene EG14108 yfcE # FUNCTION YFCE_ECOLI Shows phosphodiesterase activity, hydrolyzing phosphodiesters bonds in the artificial chromogenic substrates bis-p-nitrophenyl phosphate (bis-pNPP), and less efficiently thymidine 5'-monophosphate p-nitrophenyl ester (pNP-TMP) and p- nitrophenylphosphorylcholine (pNPPC). The physiological substrate is unknown. {ECO 0000269|PubMed 15808744}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_function GO:0016787 hydrolase activity; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # Gene3D 3.60.21.10 -; 1. # InterPro IPR000979 Phosphodiesterase_MJ0936/Vps29 # InterPro IPR020935 PdiEstase_YfcE_CS # InterPro IPR024654 Calcineurin-like_PHP_lpxH # InterPro IPR029052 Metallo-depent_PP-like # Organism YFCE_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11124 PTHR11124 # PATRIC 32119971 VBIEscCol129921_2395 # PDB 1SU1 X-ray; 2.25 A; A/B/C/D=1-184 # PIR B65002 B65002 # PROSITE PS01269 UPF0025 # Pfam PF12850 Metallophos_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFCE_ECOLI Phosphodiesterase YfcE # RefSeq NP_416803 NC_000913.3 # SIMILARITY Belongs to the metallophosphoesterase superfamily. YfcE family. {ECO 0000305}. # SUPFAM SSF56300 SSF56300 # TIGRFAMs TIGR00040 yfcE # eggNOG COG0622 LUCA # eggNOG ENOG4108RE9 Bacteria BLAST swissprot:YFCE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFCE_ECOLI BioCyc ECOL316407:JW5377-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5377-MONOMER BioCyc EcoCyc:G7192-MONOMER http://biocyc.org/getid?id=EcoCyc:G7192-MONOMER COG COG0622 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0622 DOI 10.1016/j.fmrre.2004.12.006 http://dx.doi.org/10.1016/j.fmrre.2004.12.006 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.4.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.4.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.4.- http://enzyme.expasy.org/EC/3.1.4.- EchoBASE EB3861 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3861 EcoGene EG14108 http://www.ecogene.org/geneInfo.php?eg_id=EG14108 EnsemblBacteria AAC75360 http://www.ensemblgenomes.org/id/AAC75360 EnsemblBacteria AAC75360 http://www.ensemblgenomes.org/id/AAC75360 EnsemblBacteria BAE76687 http://www.ensemblgenomes.org/id/BAE76687 EnsemblBacteria BAE76687 http://www.ensemblgenomes.org/id/BAE76687 EnsemblBacteria BAE76687 http://www.ensemblgenomes.org/id/BAE76687 EnsemblBacteria b2300 http://www.ensemblgenomes.org/id/b2300 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0016787 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016787 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.60.21.10 http://www.cathdb.info/version/latest/superfamily/3.60.21.10 GeneID 946755 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946755 HOGENOM HOG000293432 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000293432&db=HOGENOM6 InParanoid P67095 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P67095 IntEnz 3.1.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.4 InterPro IPR000979 http://www.ebi.ac.uk/interpro/entry/IPR000979 InterPro IPR020935 http://www.ebi.ac.uk/interpro/entry/IPR020935 InterPro IPR024654 http://www.ebi.ac.uk/interpro/entry/IPR024654 InterPro IPR029052 http://www.ebi.ac.uk/interpro/entry/IPR029052 KEGG_Gene ecj:JW5377 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5377 KEGG_Gene eco:b2300 http://www.genome.jp/dbget-bin/www_bget?eco:b2300 KEGG_Orthology KO:K07095 http://www.genome.jp/dbget-bin/www_bget?KO:K07095 OMA DILYHGP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DILYHGP PANTHER PTHR11124 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11124 PDB 1SU1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1SU1 PDBsum 1SU1 http://www.ebi.ac.uk/pdbsum/1SU1 PROSITE PS01269 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01269 PSORT swissprot:YFCE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFCE_ECOLI PSORT-B swissprot:YFCE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFCE_ECOLI PSORT2 swissprot:YFCE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFCE_ECOLI Pfam PF12850 http://pfam.xfam.org/family/PF12850 Phobius swissprot:YFCE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFCE_ECOLI PhylomeDB P67095 http://phylomedb.org/?seqid=P67095 ProteinModelPortal P67095 http://www.proteinmodelportal.org/query/uniprot/P67095 PubMed 15808744 http://www.ncbi.nlm.nih.gov/pubmed/15808744 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416803 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416803 SMR P67095 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P67095 STRING 511145.b2300 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2300&targetmode=cogs STRING COG0622 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0622&targetmode=cogs SUPFAM SSF56300 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56300 TIGRFAMs TIGR00040 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00040 UniProtKB YFCE_ECOLI http://www.uniprot.org/uniprot/YFCE_ECOLI UniProtKB-AC P67095 http://www.uniprot.org/uniprot/P67095 charge swissprot:YFCE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFCE_ECOLI eggNOG COG0622 http://eggnogapi.embl.de/nog_data/html/tree/COG0622 eggNOG ENOG4108RE9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108RE9 epestfind swissprot:YFCE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFCE_ECOLI garnier swissprot:YFCE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFCE_ECOLI helixturnhelix swissprot:YFCE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFCE_ECOLI hmoment swissprot:YFCE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFCE_ECOLI iep swissprot:YFCE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFCE_ECOLI inforesidue swissprot:YFCE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFCE_ECOLI octanol swissprot:YFCE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFCE_ECOLI pepcoil swissprot:YFCE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFCE_ECOLI pepdigest swissprot:YFCE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFCE_ECOLI pepinfo swissprot:YFCE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFCE_ECOLI pepnet swissprot:YFCE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFCE_ECOLI pepstats swissprot:YFCE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFCE_ECOLI pepwheel swissprot:YFCE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFCE_ECOLI pepwindow swissprot:YFCE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFCE_ECOLI sigcleave swissprot:YFCE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFCE_ECOLI ## Database ID URL or Descriptions # AltName 23S rRNA(m5U1939)-methyltransferase {ECO:0000255|HAMAP-Rule MF_01010} # BRENDA 2.1.1.190 2026 # BioGrid 4262285 11 # CATALYTIC ACTIVITY RLMD_ECOLI S-adenosyl-L-methionine + uracil(1939) in 23S rRNA = S-adenosyl-L-homocysteine + 5-methyluracil(1939) in 23S rRNA. {ECO 0000255|HAMAP-Rule MF_01010, ECO 0000269|PubMed 11779873, ECO 0000269|PubMed 12907714}. # DOMAIN RLMD_ECOLI Contains three structural domains an N-terminal TRAM domain, a central domain containing an iron-sulfur cluster, and a C-terminal domain that displays the typical SAM-dependent methyltransferase fold. {ECO 0000269|PubMed 15016356}. # EcoGene EG11247 rlmD # FUNCTION RLMD_ECOLI Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA. {ECO 0000255|HAMAP-Rule MF_01010, ECO 0000269|PubMed 11779873, ECO 0000269|PubMed 12907714}. # GO_function GO:0003723 RNA binding; IEA:InterPro. # GO_function GO:0005506 iron ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IDA:EcoCyc. # GO_function GO:0070041 rRNA (uridine-C5-)-methyltransferase activity; IDA:EcoCyc. # GO_process GO:0070475 rRNA base methylation; IDA:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0008168 methyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.50.150 -; 1. # HAMAP MF_01010 23SrRNA_methyltr_RlmD # InterPro IPR001566 23S_rRNA_MeTrfase_RlmD # InterPro IPR002792 TRAM_dom # InterPro IPR010280 U5_MeTrfase_fam # InterPro IPR012340 NA-bd_OB-fold # InterPro IPR029063 SAM-dependent_MTases # InterPro IPR030390 MeTrfase_TrmA_AS # InterPro IPR030391 MeTrfase_TrmA_CS # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # MISCELLANEOUS The function of the iron-sulfur cluster remains unclear. It may be involved in the correct folding of the protein or may have a role in RNA binding. {ECO:0000305|PubMed 15016356}. # Organism RLMD_ECOLI Escherichia coli (strain K12) # PATRIC 32120986 VBIEscCol129921_2885 # PDB 1UWV X-ray; 1.95 A; A=1-433 # PDB 2BH2 X-ray; 2.15 A; A/B=2-433 # PIR E65060 E65060 # PROSITE PS01230 TRMA_1 # PROSITE PS01231 TRMA_2 # PROSITE PS50926 TRAM # PROSITE PS51687 SAM_MT_RNA_M5U # Pfam PF01938 TRAM # Pfam PF05958 tRNA_U5-meth_tr # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD {ECO:0000255|HAMAP-Rule MF_01010} # RefSeq NP_417265 NC_000913.3 # RefSeq WP_000046812 NZ_LN832404.1 # SIMILARITY Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily. {ECO:0000255|HAMAP-Rule MF_01010}. # SIMILARITY Contains 1 TRAM domain. {ECO:0000255|HAMAP- Rule MF_01010}. # SUPFAM SSF50249 SSF50249 # SUPFAM SSF53335 SSF53335 # TIGRFAMs TIGR00479 rumA # eggNOG COG2265 LUCA # eggNOG ENOG4105BZT Bacteria BLAST swissprot:RLMD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RLMD_ECOLI BioCyc ECOL316407:JW2756-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2756-MONOMER BioCyc EcoCyc:EG11247-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11247-MONOMER BioCyc MetaCyc:EG11247-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11247-MONOMER COG COG2265 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2265 DIP DIP-12119N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12119N DOI 10.1016/j.cell.2004.12.037 http://dx.doi.org/10.1016/j.cell.2004.12.037 DOI 10.1016/j.str.2004.02.009 http://dx.doi.org/10.1016/j.str.2004.02.009 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M111825200 http://dx.doi.org/10.1074/jbc.M111825200 DOI 10.1093/nar/gkg657 http://dx.doi.org/10.1093/nar/gkg657 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.1.190 {ECO:0000255|HAMAP-Rule:MF_01010} http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.190 {ECO:0000255|HAMAP-Rule:MF_01010} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29580 http://www.ebi.ac.uk/ena/data/view/U29580 ENZYME 2.1.1.190 {ECO:0000255|HAMAP-Rule:MF_01010} http://enzyme.expasy.org/EC/2.1.1.190 {ECO:0000255|HAMAP-Rule:MF_01010} EchoBASE EB1228 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1228 EcoGene EG11247 http://www.ecogene.org/geneInfo.php?eg_id=EG11247 EnsemblBacteria AAC75827 http://www.ensemblgenomes.org/id/AAC75827 EnsemblBacteria AAC75827 http://www.ensemblgenomes.org/id/AAC75827 EnsemblBacteria BAE76859 http://www.ensemblgenomes.org/id/BAE76859 EnsemblBacteria BAE76859 http://www.ensemblgenomes.org/id/BAE76859 EnsemblBacteria BAE76859 http://www.ensemblgenomes.org/id/BAE76859 EnsemblBacteria b2785 http://www.ensemblgenomes.org/id/b2785 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_function GO:0070041 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070041 GO_process GO:0070475 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070475 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 GeneID 947243 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947243 HAMAP MF_01010 http://hamap.expasy.org/unirule/MF_01010 HOGENOM HOG000029868 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000029868&db=HOGENOM6 InParanoid P55135 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P55135 IntAct P55135 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P55135* IntEnz 2.1.1.190 {ECO:0000255|HAMAP-Rule:MF_01010} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.190 {ECO:0000255|HAMAP-Rule:MF_01010} InterPro IPR001566 http://www.ebi.ac.uk/interpro/entry/IPR001566 InterPro IPR002792 http://www.ebi.ac.uk/interpro/entry/IPR002792 InterPro IPR010280 http://www.ebi.ac.uk/interpro/entry/IPR010280 InterPro IPR012340 http://www.ebi.ac.uk/interpro/entry/IPR012340 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 InterPro IPR030390 http://www.ebi.ac.uk/interpro/entry/IPR030390 InterPro IPR030391 http://www.ebi.ac.uk/interpro/entry/IPR030391 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW2756 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2756 KEGG_Gene eco:b2785 http://www.genome.jp/dbget-bin/www_bget?eco:b2785 KEGG_Orthology KO:K03215 http://www.genome.jp/dbget-bin/www_bget?KO:K03215 OMA DLDPFGQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DLDPFGQ PDB 1UWV http://www.ebi.ac.uk/pdbe-srv/view/entry/1UWV PDB 2BH2 http://www.ebi.ac.uk/pdbe-srv/view/entry/2BH2 PDBsum 1UWV http://www.ebi.ac.uk/pdbsum/1UWV PDBsum 2BH2 http://www.ebi.ac.uk/pdbsum/2BH2 PROSITE PS01230 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01230 PROSITE PS01231 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01231 PROSITE PS50926 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50926 PROSITE PS51687 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51687 PSORT swissprot:RLMD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RLMD_ECOLI PSORT-B swissprot:RLMD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RLMD_ECOLI PSORT2 swissprot:RLMD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RLMD_ECOLI Pfam PF01938 http://pfam.xfam.org/family/PF01938 Pfam PF05958 http://pfam.xfam.org/family/PF05958 Phobius swissprot:RLMD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RLMD_ECOLI PhylomeDB P55135 http://phylomedb.org/?seqid=P55135 ProteinModelPortal P55135 http://www.proteinmodelportal.org/query/uniprot/P55135 PubMed 11779873 http://www.ncbi.nlm.nih.gov/pubmed/11779873 PubMed 12907714 http://www.ncbi.nlm.nih.gov/pubmed/12907714 PubMed 15016356 http://www.ncbi.nlm.nih.gov/pubmed/15016356 PubMed 15766524 http://www.ncbi.nlm.nih.gov/pubmed/15766524 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417265 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417265 RefSeq WP_000046812 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000046812 SMR P55135 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P55135 STRING 511145.b2785 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2785&targetmode=cogs STRING COG2265 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2265&targetmode=cogs SUPFAM SSF50249 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50249 SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 TIGRFAMs TIGR00479 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00479 UniProtKB RLMD_ECOLI http://www.uniprot.org/uniprot/RLMD_ECOLI UniProtKB-AC P55135 http://www.uniprot.org/uniprot/P55135 charge swissprot:RLMD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RLMD_ECOLI eggNOG COG2265 http://eggnogapi.embl.de/nog_data/html/tree/COG2265 eggNOG ENOG4105BZT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZT epestfind swissprot:RLMD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RLMD_ECOLI garnier swissprot:RLMD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RLMD_ECOLI helixturnhelix swissprot:RLMD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RLMD_ECOLI hmoment swissprot:RLMD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RLMD_ECOLI iep swissprot:RLMD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RLMD_ECOLI inforesidue swissprot:RLMD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RLMD_ECOLI octanol swissprot:RLMD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RLMD_ECOLI pepcoil swissprot:RLMD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RLMD_ECOLI pepdigest swissprot:RLMD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RLMD_ECOLI pepinfo swissprot:RLMD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RLMD_ECOLI pepnet swissprot:RLMD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RLMD_ECOLI pepstats swissprot:RLMD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RLMD_ECOLI pepwheel swissprot:RLMD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RLMD_ECOLI pepwindow swissprot:RLMD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RLMD_ECOLI sigcleave swissprot:RLMD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RLMD_ECOLI ## Database ID URL or Descriptions # BioGrid 4261238 17 # CATALYTIC ACTIVITY TYRA_ECOLI Chorismate = prephenate. # CATALYTIC ACTIVITY TYRA_ECOLI Prephenate + NAD(+) = 4-hydroxyphenylpyruvate + CO(2) + NADH. # EcoGene EG11039 tyrA # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0004106 chorismate mutase activity; IDA:EcoCyc. # GO_function GO:0004665 prephenate dehydrogenase (NADP+) activity; IBA:GO_Central. # GO_function GO:0008977 prephenate dehydrogenase activity; IDA:EcoCyc. # GO_function GO:0070403 NAD+ binding; IBA:GO_Central. # GO_process GO:0006571 tyrosine biosynthetic process; IDA:EcoCyc. # GO_process GO:0009094 L-phenylalanine biosynthetic process; IDA:EcoCyc. # GO_process GO:0046417 chorismate metabolic process; IEA:InterPro. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.20.59.10 -; 1. # Gene3D 3.40.50.720 -; 1. # InterPro IPR002701 Chorismate_mutase # InterPro IPR003099 Prephen_DH # InterPro IPR008244 Chor_mut/prephenate_DH_T # InterPro IPR008927 6-PGluconate_DH_C-like # InterPro IPR011277 CM_T # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR020822 Chorismate_mutase_type_II # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis # KEGG_Pathway ko00401 Novobiocin biosynthesis # Organism TYRA_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-tyrosine biosynthesis; (4- hydroxyphenyl)pyruvate from prephenate (NAD(+) route) step 1/1. # PATHWAY Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate step 1/1. # PATRIC 32120599 VBIEscCol129921_2698 # PIR A30274 KMECTD # PIRSF PIRSF001499 Chor_mut_pdh_Tpr # PROSITE PS51168 CHORISMATE_MUT_2 # PROSITE PS51176 PDH_ADH # Pfam PF01817 CM_2 # Pfam PF02153 PDH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TYRA_ECOLI Chorismate mutase # RecName TYRA_ECOLI Prephenate dehydrogenase # RecName TYRA_ECOLI T-protein # RecName TYRA_ECOLI T-protein # RefSeq NP_417091 NC_000913.3 # RefSeq WP_000225229 NZ_LN832404.1 # SIMILARITY Contains 1 chorismate mutase domain. {ECO:0000255|PROSITE-ProRule PRU00515}. # SIMILARITY Contains 1 prephenate/arogenate dehydrogenase domain. {ECO:0000255|PROSITE-ProRule PRU00522}. # SMART SM00830 CM_2 # SUBCELLULAR LOCATION TYRA_ECOLI Cytoplasm. # SUPFAM SSF48179 SSF48179 # SUPFAM SSF48600 SSF48600 # SUPFAM SSF51735 SSF51735 # TIGRFAMs TIGR01799 CM_T # UniPathway UPA00120 UER00203 # UniPathway UPA00122 UER00961 # eggNOG COG0287 LUCA # eggNOG COG1605 LUCA # eggNOG ENOG4105EHE Bacteria BLAST swissprot:TYRA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TYRA_ECOLI BioCyc ECOL316407:JW2581-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2581-MONOMER BioCyc EcoCyc:CHORISMUTPREPHENDEHYDROG-MONOMER http://biocyc.org/getid?id=EcoCyc:CHORISMUTPREPHENDEHYDROG-MONOMER BioCyc MetaCyc:CHORISMUTPREPHENDEHYDROG-MONOMER http://biocyc.org/getid?id=MetaCyc:CHORISMUTPREPHENDEHYDROG-MONOMER COG COG0287 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0287 COG COG1605 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1605 DIP DIP-11059N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11059N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0022-2836(84)90269-9 http://dx.doi.org/10.1016/0022-2836(84)90269-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.3.1.12 http://www.genome.jp/dbget-bin/www_bget?EC:1.3.1.12 EC_number EC:5.4.99.5 http://www.genome.jp/dbget-bin/www_bget?EC:5.4.99.5 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M10431 http://www.ebi.ac.uk/ena/data/view/M10431 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.3.1.12 http://enzyme.expasy.org/EC/1.3.1.12 ENZYME 5.4.99.5 http://enzyme.expasy.org/EC/5.4.99.5 EchoBASE EB1032 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1032 EcoGene EG11039 http://www.ecogene.org/geneInfo.php?eg_id=EG11039 EnsemblBacteria AAC75649 http://www.ensemblgenomes.org/id/AAC75649 EnsemblBacteria AAC75649 http://www.ensemblgenomes.org/id/AAC75649 EnsemblBacteria BAA16485 http://www.ensemblgenomes.org/id/BAA16485 EnsemblBacteria BAA16485 http://www.ensemblgenomes.org/id/BAA16485 EnsemblBacteria BAA16485 http://www.ensemblgenomes.org/id/BAA16485 EnsemblBacteria b2600 http://www.ensemblgenomes.org/id/b2600 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004106 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004106 GO_function GO:0004665 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004665 GO_function GO:0008977 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008977 GO_function GO:0070403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070403 GO_process GO:0006571 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006571 GO_process GO:0009094 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009094 GO_process GO:0046417 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046417 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.20.59.10 http://www.cathdb.info/version/latest/superfamily/1.20.59.10 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 947115 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947115 HOGENOM HOG000275725 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275725&db=HOGENOM6 InParanoid P07023 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P07023 IntAct P07023 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P07023* IntEnz 1.3.1.12 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.3.1.12 IntEnz 5.4.99.5 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.4.99.5 InterPro IPR002701 http://www.ebi.ac.uk/interpro/entry/IPR002701 InterPro IPR003099 http://www.ebi.ac.uk/interpro/entry/IPR003099 InterPro IPR008244 http://www.ebi.ac.uk/interpro/entry/IPR008244 InterPro IPR008927 http://www.ebi.ac.uk/interpro/entry/IPR008927 InterPro IPR011277 http://www.ebi.ac.uk/interpro/entry/IPR011277 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR020822 http://www.ebi.ac.uk/interpro/entry/IPR020822 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2581 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2581 KEGG_Gene eco:b2600 http://www.genome.jp/dbget-bin/www_bget?eco:b2600 KEGG_Orthology KO:K14187 http://www.genome.jp/dbget-bin/www_bget?KO:K14187 KEGG_Pathway ko00400 http://www.genome.jp/kegg-bin/show_pathway?ko00400 KEGG_Pathway ko00401 http://www.genome.jp/kegg-bin/show_pathway?ko00401 KEGG_Reaction rn:R01715 http://www.genome.jp/dbget-bin/www_bget?rn:R01715 KEGG_Reaction rn:R01728 http://www.genome.jp/dbget-bin/www_bget?rn:R01728 MINT MINT-1255670 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1255670 OMA QANDSRQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QANDSRQ PROSITE PS51168 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51168 PROSITE PS51176 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51176 PSORT swissprot:TYRA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TYRA_ECOLI PSORT-B swissprot:TYRA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TYRA_ECOLI PSORT2 swissprot:TYRA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TYRA_ECOLI Pfam PF01817 http://pfam.xfam.org/family/PF01817 Pfam PF02153 http://pfam.xfam.org/family/PF02153 Phobius swissprot:TYRA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TYRA_ECOLI PhylomeDB P07023 http://phylomedb.org/?seqid=P07023 ProteinModelPortal P07023 http://www.proteinmodelportal.org/query/uniprot/P07023 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6396419 http://www.ncbi.nlm.nih.gov/pubmed/6396419 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417091 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417091 RefSeq WP_000225229 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000225229 SMART SM00830 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00830 SMR P07023 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P07023 STRING 511145.b2600 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2600&targetmode=cogs STRING COG0287 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0287&targetmode=cogs STRING COG1605 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1605&targetmode=cogs SUPFAM SSF48179 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48179 SUPFAM SSF48600 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48600 SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 TIGRFAMs TIGR01799 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01799 UniProtKB TYRA_ECOLI http://www.uniprot.org/uniprot/TYRA_ECOLI UniProtKB-AC P07023 http://www.uniprot.org/uniprot/P07023 charge swissprot:TYRA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TYRA_ECOLI eggNOG COG0287 http://eggnogapi.embl.de/nog_data/html/tree/COG0287 eggNOG COG1605 http://eggnogapi.embl.de/nog_data/html/tree/COG1605 eggNOG ENOG4105EHE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EHE epestfind swissprot:TYRA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TYRA_ECOLI garnier swissprot:TYRA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TYRA_ECOLI helixturnhelix swissprot:TYRA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TYRA_ECOLI hmoment swissprot:TYRA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TYRA_ECOLI iep swissprot:TYRA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TYRA_ECOLI inforesidue swissprot:TYRA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TYRA_ECOLI octanol swissprot:TYRA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TYRA_ECOLI pepcoil swissprot:TYRA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TYRA_ECOLI pepdigest swissprot:TYRA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TYRA_ECOLI pepinfo swissprot:TYRA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TYRA_ECOLI pepnet swissprot:TYRA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TYRA_ECOLI pepstats swissprot:TYRA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TYRA_ECOLI pepwheel swissprot:TYRA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TYRA_ECOLI pepwindow swissprot:TYRA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TYRA_ECOLI sigcleave swissprot:TYRA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TYRA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260489 115 # CDD cd06174 MFS # EcoGene EG14084 rhmT # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IBA:GO_Central. # GO_function GO:0022857 transmembrane transporter activity; IBA:GO_Central. # GO_process GO:0006820 anion transport; IBA:GO_Central. # GO_process GO:0055085 transmembrane transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # MISCELLANEOUS RHMT_ECOLI Part of the rhmRDTA operon involved in L-rhamnonate utilization. # Organism RHMT_ECOLI Escherichia coli (strain K12) # PATRIC 32119855 VBIEscCol129921_2337 # PIR D64995 D64995 # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RHMT_ECOLI Inner membrane transport protein RhmT # RefSeq NP_416749 NC_000913.3 # RefSeq WP_000100890 NZ_LN832404.1 # SIMILARITY Belongs to the major facilitator superfamily. Phthalate permease family. {ECO 0000305}. # SUBCELLULAR LOCATION RHMT_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.14.35 the major facilitator superfamily (mfs) # eggNOG ENOG4105CSP Bacteria # eggNOG ENOG410XNQ6 LUCA BLAST swissprot:RHMT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RHMT_ECOLI BioCyc ECOL316407:JW2240-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2240-MONOMER BioCyc EcoCyc:B2246-MONOMER http://biocyc.org/getid?id=EcoCyc:B2246-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3837 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3837 EcoGene EG14084 http://www.ecogene.org/geneInfo.php?eg_id=EG14084 EnsemblBacteria AAC75306 http://www.ensemblgenomes.org/id/AAC75306 EnsemblBacteria AAC75306 http://www.ensemblgenomes.org/id/AAC75306 EnsemblBacteria BAA16070 http://www.ensemblgenomes.org/id/BAA16070 EnsemblBacteria BAA16070 http://www.ensemblgenomes.org/id/BAA16070 EnsemblBacteria BAA16070 http://www.ensemblgenomes.org/id/BAA16070 EnsemblBacteria b2246 http://www.ensemblgenomes.org/id/b2246 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GO_process GO:0006820 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006820 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 945796 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945796 HOGENOM HOG000135240 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000135240&db=HOGENOM6 InParanoid P76470 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76470 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Gene ecj:JW2240 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2240 KEGG_Gene eco:b2246 http://www.genome.jp/dbget-bin/www_bget?eco:b2246 OMA IYFAFVM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IYFAFVM PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:RHMT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RHMT_ECOLI PSORT-B swissprot:RHMT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RHMT_ECOLI PSORT2 swissprot:RHMT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RHMT_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:RHMT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RHMT_ECOLI PhylomeDB P76470 http://phylomedb.org/?seqid=P76470 ProteinModelPortal P76470 http://www.proteinmodelportal.org/query/uniprot/P76470 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416749 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416749 RefSeq WP_000100890 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000100890 STRING 511145.b2246 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2246&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.14.35 http://www.tcdb.org/search/result.php?tc=2.A.1.14.35 UniProtKB RHMT_ECOLI http://www.uniprot.org/uniprot/RHMT_ECOLI UniProtKB-AC P76470 http://www.uniprot.org/uniprot/P76470 charge swissprot:RHMT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RHMT_ECOLI eggNOG ENOG4105CSP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CSP eggNOG ENOG410XNQ6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNQ6 epestfind swissprot:RHMT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RHMT_ECOLI garnier swissprot:RHMT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RHMT_ECOLI helixturnhelix swissprot:RHMT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RHMT_ECOLI hmoment swissprot:RHMT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RHMT_ECOLI iep swissprot:RHMT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RHMT_ECOLI inforesidue swissprot:RHMT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RHMT_ECOLI octanol swissprot:RHMT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RHMT_ECOLI pepcoil swissprot:RHMT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RHMT_ECOLI pepdigest swissprot:RHMT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RHMT_ECOLI pepinfo swissprot:RHMT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RHMT_ECOLI pepnet swissprot:RHMT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RHMT_ECOLI pepstats swissprot:RHMT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RHMT_ECOLI pepwheel swissprot:RHMT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RHMT_ECOLI pepwindow swissprot:RHMT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RHMT_ECOLI sigcleave swissprot:RHMT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RHMT_ECOLI ## Database ID URL or Descriptions # AltName YQAB_ECOLI Fructose-1-phosphatase # BIOPHYSICOCHEMICAL PROPERTIES YQAB_ECOLI Kinetic parameters KM=1 mM for Fru1P (with magnesium ions as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; KM=3.9 mM for 6P-Glu (with magnesium ions as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; pH dependence Optimum pH is between 6 and 7.5. {ECO 0000269|PubMed 16990279}; # BioGrid 4262273 22 # COFACTOR YQAB_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 16990279}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 16990279}; Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000269|PubMed 16990279}; Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 16990279}; Note=Magnesium. Can also use other divalent metal cations as manganese, cobalt or zinc. {ECO 0000269|PubMed 16990279}; # EcoGene EG13530 yqaB # FUNCTION YQAB_ECOLI Catalyzes strongly the dephosphorylation of fructose-1- phosphate (Fru1P) and slightly the dephosphorylation of 6- phosphogluconate (6P-Glu). It has low beta-phosphoglucomutase activity. {ECO 0000269|PubMed 15808744, ECO 0000269|PubMed 16990279}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0000287 magnesium ion binding; IDA:UniProtKB. # GO_function GO:0008801 beta-phosphoglucomutase activity; IDA:EcoliWiki. # GO_function GO:0016791 phosphatase activity; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # Gene3D 1.10.150.240 -; 1. # Gene3D 3.40.50.1000 -; 2. # IntAct P77475 5 # InterPro IPR006439 HAD-SF_hydro_IA # InterPro IPR010976 B-phosphoglucomutase_hydrolase # InterPro IPR023198 PGP_dom2 # InterPro IPR023214 HAD-like_dom # Organism YQAB_ECOLI Escherichia coli (strain K12) # PATRIC 32120774 VBIEscCol129921_2784 # PIR C65049 C65049 # PRINTS PR00413 HADHALOGNASE # Pfam PF13419 HAD_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQAB_ECOLI Fructose-1-phosphate phosphatase YqaB # RefSeq NP_417175 NC_000913.3 # RefSeq WP_000273290 NZ_LN832404.1 # SIMILARITY Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. {ECO 0000305}. # SUPFAM SSF56784 SSF56784 # TIGRFAMs TIGR01509 HAD-SF-IA-v3 # TIGRFAMs TIGR02009 PGMB-YQAB-SF # eggNOG COG0637 LUCA # eggNOG ENOG4107VXZ Bacteria BLAST swissprot:YQAB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQAB_ECOLI BioCyc ECOL316407:JW2665-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2665-MONOMER BioCyc EcoCyc:G7408-MONOMER http://biocyc.org/getid?id=EcoCyc:G7408-MONOMER BioCyc MetaCyc:G7408-MONOMER http://biocyc.org/getid?id=MetaCyc:G7408-MONOMER DIP DIP-12842N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12842N DOI 10.1016/j.fmrre.2004.12.006 http://dx.doi.org/10.1016/j.fmrre.2004.12.006 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M605449200 http://dx.doi.org/10.1074/jbc.M605449200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.3.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.3.- http://enzyme.expasy.org/EC/3.1.3.- EchoBASE EB3301 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3301 EcoGene EG13530 http://www.ecogene.org/geneInfo.php?eg_id=EG13530 EnsemblBacteria AAC75737 http://www.ensemblgenomes.org/id/AAC75737 EnsemblBacteria AAC75737 http://www.ensemblgenomes.org/id/AAC75737 EnsemblBacteria BAA16557 http://www.ensemblgenomes.org/id/BAA16557 EnsemblBacteria BAA16557 http://www.ensemblgenomes.org/id/BAA16557 EnsemblBacteria BAA16557 http://www.ensemblgenomes.org/id/BAA16557 EnsemblBacteria b2690 http://www.ensemblgenomes.org/id/b2690 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0008801 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008801 GO_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 1.10.150.240 http://www.cathdb.info/version/latest/superfamily/1.10.150.240 Gene3D 3.40.50.1000 http://www.cathdb.info/version/latest/superfamily/3.40.50.1000 GeneID 945776 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945776 HOGENOM HOG000248341 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000248341&db=HOGENOM6 InParanoid P77475 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77475 IntAct P77475 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77475* IntEnz 3.1.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3 InterPro IPR006439 http://www.ebi.ac.uk/interpro/entry/IPR006439 InterPro IPR010976 http://www.ebi.ac.uk/interpro/entry/IPR010976 InterPro IPR023198 http://www.ebi.ac.uk/interpro/entry/IPR023198 InterPro IPR023214 http://www.ebi.ac.uk/interpro/entry/IPR023214 KEGG_Gene ecj:JW2665 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2665 KEGG_Gene eco:b2690 http://www.genome.jp/dbget-bin/www_bget?eco:b2690 MINT MINT-1265616 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1265616 OMA CAQRMGI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CAQRMGI PRINTS PR00413 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00413 PSORT swissprot:YQAB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQAB_ECOLI PSORT-B swissprot:YQAB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQAB_ECOLI PSORT2 swissprot:YQAB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQAB_ECOLI Pfam PF13419 http://pfam.xfam.org/family/PF13419 Phobius swissprot:YQAB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQAB_ECOLI PhylomeDB P77475 http://phylomedb.org/?seqid=P77475 ProteinModelPortal P77475 http://www.proteinmodelportal.org/query/uniprot/P77475 PubMed 15808744 http://www.ncbi.nlm.nih.gov/pubmed/15808744 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16990279 http://www.ncbi.nlm.nih.gov/pubmed/16990279 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417175 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417175 RefSeq WP_000273290 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000273290 SMR P77475 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77475 STRING 511145.b2690 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2690&targetmode=cogs SUPFAM SSF56784 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784 TIGRFAMs TIGR01509 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01509 TIGRFAMs TIGR02009 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02009 UniProtKB YQAB_ECOLI http://www.uniprot.org/uniprot/YQAB_ECOLI UniProtKB-AC P77475 http://www.uniprot.org/uniprot/P77475 charge swissprot:YQAB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQAB_ECOLI eggNOG COG0637 http://eggnogapi.embl.de/nog_data/html/tree/COG0637 eggNOG ENOG4107VXZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107VXZ epestfind swissprot:YQAB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQAB_ECOLI garnier swissprot:YQAB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQAB_ECOLI helixturnhelix swissprot:YQAB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQAB_ECOLI hmoment swissprot:YQAB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQAB_ECOLI iep swissprot:YQAB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQAB_ECOLI inforesidue swissprot:YQAB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQAB_ECOLI octanol swissprot:YQAB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQAB_ECOLI pepcoil swissprot:YQAB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQAB_ECOLI pepdigest swissprot:YQAB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQAB_ECOLI pepinfo swissprot:YQAB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQAB_ECOLI pepnet swissprot:YQAB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQAB_ECOLI pepstats swissprot:YQAB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQAB_ECOLI pepwheel swissprot:YQAB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQAB_ECOLI pepwindow swissprot:YQAB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQAB_ECOLI sigcleave swissprot:YQAB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQAB_ECOLI ## Database ID URL or Descriptions # AltName MDFA_ECOLI Chloramphenicol resistance pump Cmr # BIOPHYSICOCHEMICAL PROPERTIES pH dependence: Optimum pH is 6.5. {ECO 0000269|PubMed:9644262}; # BioGrid 4262828 106 # CDD cd06174 MFS # ENZYME REGULATION Inhibited by CCCP. {ECO:0000269|PubMed 9644262}. # EcoGene EG13696 mdfA # FUNCTION MDFA_ECOLI Efflux pump driven by the proton motive force. Confers resistance to a broad spectrum of chemically unrelated drugs. Confers resistance to a diverse group of cationic or zwitterionic lipophilic compounds such as ethidium bromide, tetraphenylphosphonium, rhodamine, daunomycin, benzalkonium, rifampicin, tetracycline, puromycin, and to chemically unrelated, clinically important antibiotics such as chloramphenicol, erythromycin, and certain aminoglycosides and fluoroquinolones. Overexpression results in isopropyl-beta-D-thiogalactopyranoside (IPTG) exclusion and spectinomycin sensitivity. Transport of neutral substrates is electrogenic, whereas transport of cationic substrates is electroneutral. In addition to its role in multidrug resistance, confers extreme alkaline pH resistance, allowing the growth under conditions that are close to those used normally by alkaliphiles. This activity requires Na(+) or K(+). {ECO 0000269|PubMed 12578981, ECO 0000269|PubMed 15371593, ECO 0000269|PubMed 9079913, ECO 0000269|PubMed 9644262, ECO 0000269|PubMed 9811673}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_function GO:0015238 drug transmembrane transporter activity; IMP:EcoCyc. # GO_function MDFA_ECOLI GO 0015385 sodium proton antiporter activity; IDA EcoCyc. # GO_function MDFA_ECOLI GO 0015386 potassium proton antiporter activity; IDA EcoCyc. # GO_process GO:0006855 drug transmembrane transport; IMP:EcoCyc. # GO_process GO:0030641 regulation of cellular pH; IMP:EcoCyc. # GO_process GO:0046677 response to antibiotic; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0042592 homeostatic process # GOslim_process GO:0055085 transmembrane transport # InterPro IPR005829 Sugar_transporter_CS # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # KEGG_Brite ko02000 Transporters # MISCELLANEOUS MDFA_ECOLI A negative charge at position 26 is required for efficient transport of positively charged substrates, but not for neutral compounds. This negative charge does not play an essential role in the multidrug transport mechanism. # MISCELLANEOUS MDFA_ECOLI Has a sensitive conformational switch that can be triggered either by substrate binding or by attaching unrelated agents inside the pocket. Dissimilar substrates induce similar conformational changes. # Organism MDFA_ECOLI Escherichia coli (strain K12) # PATRIC 32116889 VBIEscCol129921_0870 # PDB 4ZOW X-ray; 2.45 A; A=10-400 # PDB 4ZP0 X-ray; 2.00 A; A=9-400 # PDB 4ZP2 X-ray; 2.20 A; A=9-400 # PIR B64822 B64822 # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MDFA_ECOLI Multidrug transporter MdfA # RefSeq NP_415363 NC_000913.3 # RefSeq WP_001180089 NZ_LN832404.1 # SIMILARITY Belongs to the major facilitator superfamily. MdfA family. {ECO 0000305}. # SUBCELLULAR LOCATION MDFA_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT Monomer. {ECO:0000269|PubMed 17407265}. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.2.19 the major facilitator superfamily (mfs) # eggNOG ENOG4107QF7 Bacteria # eggNOG ENOG410XT98 LUCA BLAST swissprot:MDFA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MDFA_ECOLI BioCyc ECOL316407:JW0826-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0826-MONOMER BioCyc EcoCyc:CMR-MONOMER http://biocyc.org/getid?id=EcoCyc:CMR-MONOMER BioCyc MetaCyc:CMR-MONOMER http://biocyc.org/getid?id=MetaCyc:CMR-MONOMER COG COG0477 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0477 DIP DIP-48116N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48116N DOI 10.1021/bi035485t http://dx.doi.org/10.1021/bi035485t DOI 10.1021/bi602405w http://dx.doi.org/10.1021/bi602405w DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0405375101 http://dx.doi.org/10.1073/pnas.0405375101 DOI 10.1073/pnas.0435544100 http://dx.doi.org/10.1073/pnas.0435544100 DOI 10.1074/jbc.M109.050658 http://dx.doi.org/10.1074/jbc.M109.050658 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/emboj/18.4.822 http://dx.doi.org/10.1093/emboj/18.4.822 DOI 10.1093/oxfordjournals.jbchem.a022078 http://dx.doi.org/10.1093/oxfordjournals.jbchem.a022078 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U44900 http://www.ebi.ac.uk/ena/data/view/U44900 EMBL Y08743 http://www.ebi.ac.uk/ena/data/view/Y08743 EchoBASE EB3460 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3460 EcoGene EG13696 http://www.ecogene.org/geneInfo.php?eg_id=EG13696 EnsemblBacteria AAC73929 http://www.ensemblgenomes.org/id/AAC73929 EnsemblBacteria AAC73929 http://www.ensemblgenomes.org/id/AAC73929 EnsemblBacteria BAA35546 http://www.ensemblgenomes.org/id/BAA35546 EnsemblBacteria BAA35546 http://www.ensemblgenomes.org/id/BAA35546 EnsemblBacteria BAA35546 http://www.ensemblgenomes.org/id/BAA35546 EnsemblBacteria b0842 http://www.ensemblgenomes.org/id/b0842 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015238 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015238 GO_function GO:0015385 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015385 GO_function GO:0015386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015386 GO_process GO:0006855 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006855 GO_process GO:0030641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030641 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 945448 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945448 HOGENOM HOG000118215 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118215&db=HOGENOM6 InParanoid P0AEY8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEY8 IntAct P0AEY8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEY8* InterPro IPR005829 http://www.ebi.ac.uk/interpro/entry/IPR005829 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ag:CAA69997 http://www.genome.jp/dbget-bin/www_bget?ag:CAA69997 KEGG_Gene ecj:JW0826 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0826 KEGG_Gene eco:b0842 http://www.genome.jp/dbget-bin/www_bget?eco:b0842 KEGG_Orthology KO:K08160 http://www.genome.jp/dbget-bin/www_bget?KO:K08160 MINT MINT-1227586 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1227586 OMA MQTHANR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MQTHANR PDB 4ZOW http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZOW PDB 4ZP0 http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZP0 PDB 4ZP2 http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZP2 PDBsum 4ZOW http://www.ebi.ac.uk/pdbsum/4ZOW PDBsum 4ZP0 http://www.ebi.ac.uk/pdbsum/4ZP0 PDBsum 4ZP2 http://www.ebi.ac.uk/pdbsum/4ZP2 PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:MDFA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MDFA_ECOLI PSORT-B swissprot:MDFA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MDFA_ECOLI PSORT2 swissprot:MDFA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MDFA_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:MDFA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MDFA_ECOLI PhylomeDB P0AEY8 http://phylomedb.org/?seqid=P0AEY8 ProteinModelPortal P0AEY8 http://www.proteinmodelportal.org/query/uniprot/P0AEY8 PubMed 10022825 http://www.ncbi.nlm.nih.gov/pubmed/10022825 PubMed 12578981 http://www.ncbi.nlm.nih.gov/pubmed/12578981 PubMed 14717607 http://www.ncbi.nlm.nih.gov/pubmed/14717607 PubMed 15371593 http://www.ncbi.nlm.nih.gov/pubmed/15371593 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17407265 http://www.ncbi.nlm.nih.gov/pubmed/17407265 PubMed 19808670 http://www.ncbi.nlm.nih.gov/pubmed/19808670 PubMed 8655497 http://www.ncbi.nlm.nih.gov/pubmed/8655497 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9079913 http://www.ncbi.nlm.nih.gov/pubmed/9079913 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9644262 http://www.ncbi.nlm.nih.gov/pubmed/9644262 PubMed 9811673 http://www.ncbi.nlm.nih.gov/pubmed/9811673 RefSeq NP_415363 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415363 RefSeq WP_001180089 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001180089 SMR P0AEY8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEY8 STRING 511145.b0842 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0842&targetmode=cogs STRING COG0477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0477&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.2.19 http://www.tcdb.org/search/result.php?tc=2.A.1.2.19 UniProtKB MDFA_ECOLI http://www.uniprot.org/uniprot/MDFA_ECOLI UniProtKB-AC P0AEY8 http://www.uniprot.org/uniprot/P0AEY8 charge swissprot:MDFA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MDFA_ECOLI eggNOG ENOG4107QF7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QF7 eggNOG ENOG410XT98 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XT98 epestfind swissprot:MDFA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MDFA_ECOLI garnier swissprot:MDFA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MDFA_ECOLI helixturnhelix swissprot:MDFA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MDFA_ECOLI hmoment swissprot:MDFA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MDFA_ECOLI iep swissprot:MDFA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MDFA_ECOLI inforesidue swissprot:MDFA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MDFA_ECOLI octanol swissprot:MDFA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MDFA_ECOLI pepcoil swissprot:MDFA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MDFA_ECOLI pepdigest swissprot:MDFA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MDFA_ECOLI pepinfo swissprot:MDFA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MDFA_ECOLI pepnet swissprot:MDFA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MDFA_ECOLI pepstats swissprot:MDFA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MDFA_ECOLI pepwheel swissprot:MDFA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MDFA_ECOLI pepwindow swissprot:MDFA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MDFA_ECOLI sigcleave swissprot:MDFA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MDFA_ECOLI ## Database ID URL or Descriptions # AltName 16S rRNA 7-methylguanosine methyltransferase {ECO:0000255|HAMAP-Rule MF_00074} # AltName RSMG_ECOLI Glucose-inhibited division protein B # BRENDA 2.1.1.170 2026 # BioGrid 4263261 246 # CATALYTIC ACTIVITY RSMG_ECOLI S-adenosyl-L-methionine + guanine(527) in 16S rRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(527) in 16S rRNA. {ECO 0000255|HAMAP-Rule MF_00074, ECO 0000269|PubMed 17238915}. # DISRUPTION PHENOTYPE Low-level streptomycin resistance. {ECO:0000269|PubMed 17238915}. # EcoGene EG10376 rsmG # FUNCTION RSMG_ECOLI Specifically methylates the N7 position of guanine in position 527 of 16S rRNA. Requires the intact 30S subunit for methylation. {ECO 0000255|HAMAP-Rule MF_00074, ECO 0000269|PubMed 17238915}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0070043 rRNA (guanine-N7-)-methyltransferase activity; IDA:EcoCyc. # GO_process GO:0070475 rRNA base methylation; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.50.150 -; 1. # HAMAP MF_00074 16SrRNA_methyltr_G # INDUCTION Induced under stress conditions known to stimulate ppGpp accumulation and down-regulate rRNA synthesis. {ECO:0000269|PubMed 22337945}. # IntAct P0A6U5 10 # InterPro IPR003682 rRNA_ssu_MeTfrase_G # InterPro IPR029063 SAM-dependent_MTases # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # KEGG_Brite ko03036 Chromosome # MISCELLANEOUS Mechanisms acting on transcription regulation, translation or protein stability could be responsible for adjusting RsmG expression to rRNA synthesis. {ECO:0000305|PubMed 22337945}. # Organism RSMG_ECOLI Escherichia coli (strain K12) # PATRIC 32122979 VBIEscCol129921_3865 # PDB 1JSX X-ray; 2.40 A; A=1-207 # PIR C30389 BVECQB # PIRSF PIRSF003078 GidB # Pfam PF02527 GidB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Ribosomal RNA small subunit methyltransferase G {ECO:0000255|HAMAP-Rule MF_00074} # RefSeq NP_418196 NC_000913.3 # RefSeq WP_000932839 NZ_LN832404.1 # SIMILARITY Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family. {ECO:0000255|HAMAP-Rule MF_00074}. # SUBCELLULAR LOCATION RSMG_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00074}. # SUPFAM SSF53335 SSF53335 # TIGRFAMs TIGR00138 rsmG_gidB # eggNOG COG0357 LUCA # eggNOG ENOG4105D28 Bacteria BLAST swissprot:RSMG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RSMG_ECOLI BioCyc ECOL316407:JW3718-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3718-MONOMER BioCyc EcoCyc:EG10376-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10376-MONOMER BioCyc MetaCyc:EG10376-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10376-MONOMER COG COG0357 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0357 DIP DIP-47992N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47992N DOI 10.1002/prot.10121.abs http://dx.doi.org/10.1002/prot.10121.abs DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1007/BF00327415 http://dx.doi.org/10.1007/BF00327415 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2240799 http://dx.doi.org/10.1042/bj2240799 DOI 10.1111/j.1365-2958.2006.05585.x http://dx.doi.org/10.1111/j.1365-2958.2006.05585.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1261/rna.029868.111 http://dx.doi.org/10.1261/rna.029868.111 DOI 10.7705/biomedica.v34i0.1702 http://dx.doi.org/10.7705/biomedica.v34i0.1702 EC_number EC:2.1.1.170 {ECO:0000255|HAMAP-Rule:MF_00074} http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.170 {ECO:0000255|HAMAP-Rule:MF_00074} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X01383 http://www.ebi.ac.uk/ena/data/view/X01383 EMBL X01631 http://www.ebi.ac.uk/ena/data/view/X01631 ENZYME 2.1.1.170 {ECO:0000255|HAMAP-Rule:MF_00074} http://enzyme.expasy.org/EC/2.1.1.170 {ECO:0000255|HAMAP-Rule:MF_00074} EchoBASE EB0371 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0371 EcoGene EG10376 http://www.ecogene.org/geneInfo.php?eg_id=EG10376 EnsemblBacteria AAC76763 http://www.ensemblgenomes.org/id/AAC76763 EnsemblBacteria AAC76763 http://www.ensemblgenomes.org/id/AAC76763 EnsemblBacteria BAE77548 http://www.ensemblgenomes.org/id/BAE77548 EnsemblBacteria BAE77548 http://www.ensemblgenomes.org/id/BAE77548 EnsemblBacteria BAE77548 http://www.ensemblgenomes.org/id/BAE77548 EnsemblBacteria b3740 http://www.ensemblgenomes.org/id/b3740 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0070043 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070043 GO_process GO:0070475 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070475 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 GeneID 948250 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948250 HAMAP MF_00074 http://hamap.expasy.org/unirule/MF_00074 HOGENOM HOG000221012 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000221012&db=HOGENOM6 InParanoid P0A6U5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6U5 IntAct P0A6U5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6U5* IntEnz 2.1.1.170 {ECO:0000255|HAMAP-Rule:MF_00074} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.170 {ECO:0000255|HAMAP-Rule:MF_00074} InterPro IPR003682 http://www.ebi.ac.uk/interpro/entry/IPR003682 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene ecj:JW3718 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3718 KEGG_Gene eco:b3740 http://www.genome.jp/dbget-bin/www_bget?eco:b3740 KEGG_Orthology KO:K03501 http://www.genome.jp/dbget-bin/www_bget?KO:K03501 OMA KWNGVYN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KWNGVYN PDB 1JSX http://www.ebi.ac.uk/pdbe-srv/view/entry/1JSX PDBsum 1JSX http://www.ebi.ac.uk/pdbsum/1JSX PSORT swissprot:RSMG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RSMG_ECOLI PSORT-B swissprot:RSMG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RSMG_ECOLI PSORT2 swissprot:RSMG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RSMG_ECOLI Pfam PF02527 http://pfam.xfam.org/family/PF02527 Phobius swissprot:RSMG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RSMG_ECOLI PhylomeDB P0A6U5 http://phylomedb.org/?seqid=P0A6U5 ProteinModelPortal P0A6U5 http://www.proteinmodelportal.org/query/uniprot/P0A6U5 PubMed 12001236 http://www.ncbi.nlm.nih.gov/pubmed/12001236 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17238915 http://www.ncbi.nlm.nih.gov/pubmed/17238915 PubMed 22337945 http://www.ncbi.nlm.nih.gov/pubmed/22337945 PubMed 6318052 http://www.ncbi.nlm.nih.gov/pubmed/6318052 PubMed 6395859 http://www.ncbi.nlm.nih.gov/pubmed/6395859 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418196 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418196 RefSeq WP_000932839 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000932839 SMR P0A6U5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6U5 STRING 511145.b3740 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3740&targetmode=cogs STRING COG0357 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0357&targetmode=cogs SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 TIGRFAMs TIGR00138 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00138 UniProtKB RSMG_ECOLI http://www.uniprot.org/uniprot/RSMG_ECOLI UniProtKB-AC P0A6U5 http://www.uniprot.org/uniprot/P0A6U5 charge swissprot:RSMG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RSMG_ECOLI eggNOG COG0357 http://eggnogapi.embl.de/nog_data/html/tree/COG0357 eggNOG ENOG4105D28 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D28 epestfind swissprot:RSMG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RSMG_ECOLI garnier swissprot:RSMG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RSMG_ECOLI helixturnhelix swissprot:RSMG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RSMG_ECOLI hmoment swissprot:RSMG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RSMG_ECOLI iep swissprot:RSMG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RSMG_ECOLI inforesidue swissprot:RSMG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RSMG_ECOLI octanol swissprot:RSMG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RSMG_ECOLI pepcoil swissprot:RSMG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RSMG_ECOLI pepdigest swissprot:RSMG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RSMG_ECOLI pepinfo swissprot:RSMG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RSMG_ECOLI pepnet swissprot:RSMG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RSMG_ECOLI pepstats swissprot:RSMG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RSMG_ECOLI pepwheel swissprot:RSMG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RSMG_ECOLI pepwindow swissprot:RSMG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RSMG_ECOLI sigcleave swissprot:RSMG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RSMG_ECOLI ## Database ID URL or Descriptions # AltName Z ring-associated protein D {ECO:0000255|HAMAP-Rule MF_01092} # BioGrid 4260784 2 # DISRUPTION PHENOTYPE Mutants are viable, with no discernible division phenotypes. {ECO:0000269|PubMed 22505682}. # EcoGene EG12313 zapD # FUNCTION ZAPD_ECOLI Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity. {ECO 0000255|HAMAP-Rule MF_01092, ECO 0000269|PubMed 22505682}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0032153 cell division site; IDA:EcoCyc. # GO_process GO:0043093 FtsZ-dependent cytokinesis; IGI:EcoCyc. # GO_process GO:0090529 cell septum assembly; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_process GO:0008150 biological_process # GOslim_process GO:0022607 cellular component assembly # Gene3D 2.60.440.10 -; 1. # HAMAP MF_01092 ZapD # INTERACTION ZAPD_ECOLI Self; NbExp=2; IntAct=EBI-1113728, EBI-1113728; P0A9A6 ftsZ; NbExp=3; IntAct=EBI-1113728, EBI-370963; # IntAct P36680 5 # InterPro IPR009777 ZapD # InterPro IPR027462 ZapD_C # Organism ZAPD_ECOLI Escherichia coli (strain K12) # PATRIC 32115307 VBIEscCol129921_0105 # PDB 5DKO X-ray; 2.40 A; A=1-247 # PIR F64732 F64732 # Pfam PF07072 DUF1342 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Cell division protein ZapD {ECO:0000255|HAMAP-Rule MF_01092} # RefSeq NP_414644 NC_000913.3 # RefSeq WP_001194734 NZ_LN832404.1 # SIMILARITY Belongs to the ZapD family. {ECO:0000255|HAMAP- Rule MF_01092}. # SUBCELLULAR LOCATION ZAPD_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_01092, ECO 0000269|PubMed 22505682}. Note=Localizes to mid-cell in an FtsZ-dependent manner. Localization does not require FtsA, ZipA, ZapA or ZapC. # SUBUNIT Mostly homodimer in solution. Interacts with the C- terminal tail of FtsZ. {ECO:0000269|PubMed 22505682}. # eggNOG COG4582 LUCA # eggNOG ENOG4105DHA Bacteria BLAST swissprot:ZAPD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ZAPD_ECOLI BioCyc ECOL316407:JW0099-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0099-MONOMER BioCyc EcoCyc:EG12313-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12313-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00176-12 http://dx.doi.org/10.1128/JB.00176-12 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2219 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2219 EcoGene EG12313 http://www.ecogene.org/geneInfo.php?eg_id=EG12313 EnsemblBacteria AAC73213 http://www.ensemblgenomes.org/id/AAC73213 EnsemblBacteria AAC73213 http://www.ensemblgenomes.org/id/AAC73213 EnsemblBacteria BAB96671 http://www.ensemblgenomes.org/id/BAB96671 EnsemblBacteria BAB96671 http://www.ensemblgenomes.org/id/BAB96671 EnsemblBacteria BAB96671 http://www.ensemblgenomes.org/id/BAB96671 EnsemblBacteria b0102 http://www.ensemblgenomes.org/id/b0102 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0032153 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032153 GO_process GO:0043093 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043093 GO_process GO:0090529 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090529 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 Gene3D 2.60.440.10 http://www.cathdb.info/version/latest/superfamily/2.60.440.10 GeneID 944873 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944873 HAMAP MF_01092 http://hamap.expasy.org/unirule/MF_01092 HOGENOM HOG000283874 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000283874&db=HOGENOM6 IntAct P36680 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P36680* InterPro IPR009777 http://www.ebi.ac.uk/interpro/entry/IPR009777 InterPro IPR027462 http://www.ebi.ac.uk/interpro/entry/IPR027462 KEGG_Gene ecj:JW0099 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0099 KEGG_Gene eco:b0102 http://www.genome.jp/dbget-bin/www_bget?eco:b0102 OMA LPAYYAW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LPAYYAW PDB 5DKO http://www.ebi.ac.uk/pdbe-srv/view/entry/5DKO PDBsum 5DKO http://www.ebi.ac.uk/pdbsum/5DKO PSORT swissprot:ZAPD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ZAPD_ECOLI PSORT-B swissprot:ZAPD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ZAPD_ECOLI PSORT2 swissprot:ZAPD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ZAPD_ECOLI Pfam PF07072 http://pfam.xfam.org/family/PF07072 Phobius swissprot:ZAPD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ZAPD_ECOLI ProteinModelPortal P36680 http://www.proteinmodelportal.org/query/uniprot/P36680 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22505682 http://www.ncbi.nlm.nih.gov/pubmed/22505682 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414644 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414644 RefSeq WP_001194734 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001194734 SMR P36680 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P36680 STRING 511145.b0102 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0102&targetmode=cogs UniProtKB ZAPD_ECOLI http://www.uniprot.org/uniprot/ZAPD_ECOLI UniProtKB-AC P36680 http://www.uniprot.org/uniprot/P36680 charge swissprot:ZAPD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ZAPD_ECOLI eggNOG COG4582 http://eggnogapi.embl.de/nog_data/html/tree/COG4582 eggNOG ENOG4105DHA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DHA epestfind swissprot:ZAPD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ZAPD_ECOLI garnier swissprot:ZAPD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ZAPD_ECOLI helixturnhelix swissprot:ZAPD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ZAPD_ECOLI hmoment swissprot:ZAPD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ZAPD_ECOLI iep swissprot:ZAPD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ZAPD_ECOLI inforesidue swissprot:ZAPD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ZAPD_ECOLI octanol swissprot:ZAPD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ZAPD_ECOLI pepcoil swissprot:ZAPD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ZAPD_ECOLI pepdigest swissprot:ZAPD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ZAPD_ECOLI pepinfo swissprot:ZAPD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ZAPD_ECOLI pepnet swissprot:ZAPD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ZAPD_ECOLI pepstats swissprot:ZAPD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ZAPD_ECOLI pepwheel swissprot:ZAPD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ZAPD_ECOLI pepwindow swissprot:ZAPD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ZAPD_ECOLI sigcleave swissprot:ZAPD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ZAPD_ECOLI ## Database ID URL or Descriptions # AltName MODF_ECOLI Photorepair protein PhrA # BioGrid 4263124 95 # EcoGene EG11677 modF # FUNCTION MODF_ECOLI Involved in the transport of molybdenum into the cell. Involved in photorepair. Could act on UV-induced DNA damage other than pyrimidine dimers. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016887 ATPase activity; IEA:InterPro. # GO_process GO:0006281 DNA repair; IEA:UniProtKB-KW. # GO_process GO:0006810 transport; IEA:UniProtKB-KW. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006810 transport # GOslim_process GO:0006950 response to stress # Gene3D 3.40.50.300 -; 2. # IntAct P31060 7 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00189 Molybdate transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism MODF_ECOLI Escherichia coli (strain K12) # PATRIC 32116721 VBIEscCol129921_0786 # PIR JC6038 JC6038 # PROSITE PS50893 ABC_TRANSPORTER_2; 2 # Pfam PF00005 ABC_tran; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MODF_ECOLI Putative molybdenum transport ATP-binding protein ModF # RefSeq NP_415281 NC_000913.3 # RefSeq WP_000096869 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. {ECO 0000305}. # SIMILARITY Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA; 2 # SUBCELLULAR LOCATION MODF_ECOLI Cell inner membrane {ECO 0000250}; Peripheral membrane protein {ECO 0000250}. # SUPFAM SSF52540 SSF52540; 2 # eggNOG COG1119 LUCA # eggNOG ENOG4105DKW Bacteria BLAST swissprot:MODF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MODF_ECOLI BioCyc ECOL316407:JW0743-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0743-MONOMER BioCyc EcoCyc:MODF-MONOMER http://biocyc.org/getid?id=EcoCyc:MODF-MONOMER COG COG1119 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1119 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1751-1097.1993.tb04979.x http://dx.doi.org/10.1111/j.1751-1097.1993.tb04979.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U07867 http://www.ebi.ac.uk/ena/data/view/U07867 EMBL U27192 http://www.ebi.ac.uk/ena/data/view/U27192 EMBL X69182 http://www.ebi.ac.uk/ena/data/view/X69182 EchoBASE EB1628 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1628 EcoGene EG11677 http://www.ecogene.org/geneInfo.php?eg_id=EG11677 EnsemblBacteria AAC73847 http://www.ensemblgenomes.org/id/AAC73847 EnsemblBacteria AAC73847 http://www.ensemblgenomes.org/id/AAC73847 EnsemblBacteria BAA35422 http://www.ensemblgenomes.org/id/BAA35422 EnsemblBacteria BAA35422 http://www.ensemblgenomes.org/id/BAA35422 EnsemblBacteria BAA35422 http://www.ensemblgenomes.org/id/BAA35422 EnsemblBacteria b0760 http://www.ensemblgenomes.org/id/b0760 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_process GO:0006281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006281 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945368 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945368 HOGENOM HOG000000211 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000000211&db=HOGENOM6 InParanoid P31060 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31060 IntAct P31060 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31060* InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0743 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0743 KEGG_Gene eco:b0760 http://www.genome.jp/dbget-bin/www_bget?eco:b0760 KEGG_Orthology KO:K05776 http://www.genome.jp/dbget-bin/www_bget?KO:K05776 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA QCQFTRI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QCQFTRI PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:MODF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MODF_ECOLI PSORT-B swissprot:MODF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MODF_ECOLI PSORT2 swissprot:MODF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MODF_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Phobius swissprot:MODF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MODF_ECOLI PhylomeDB P31060 http://phylomedb.org/?seqid=P31060 ProteinModelPortal P31060 http://www.proteinmodelportal.org/query/uniprot/P31060 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8310005 http://www.ncbi.nlm.nih.gov/pubmed/8310005 PubMed 8550508 http://www.ncbi.nlm.nih.gov/pubmed/8550508 PubMed 8564363 http://www.ncbi.nlm.nih.gov/pubmed/8564363 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415281 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415281 RefSeq WP_000096869 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000096869 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 STRING 511145.b0760 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0760&targetmode=cogs STRING COG1119 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1119&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB MODF_ECOLI http://www.uniprot.org/uniprot/MODF_ECOLI UniProtKB-AC P31060 http://www.uniprot.org/uniprot/P31060 charge swissprot:MODF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MODF_ECOLI eggNOG COG1119 http://eggnogapi.embl.de/nog_data/html/tree/COG1119 eggNOG ENOG4105DKW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DKW epestfind swissprot:MODF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MODF_ECOLI garnier swissprot:MODF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MODF_ECOLI helixturnhelix swissprot:MODF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MODF_ECOLI hmoment swissprot:MODF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MODF_ECOLI iep swissprot:MODF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MODF_ECOLI inforesidue swissprot:MODF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MODF_ECOLI octanol swissprot:MODF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MODF_ECOLI pepcoil swissprot:MODF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MODF_ECOLI pepdigest swissprot:MODF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MODF_ECOLI pepinfo swissprot:MODF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MODF_ECOLI pepnet swissprot:MODF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MODF_ECOLI pepstats swissprot:MODF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MODF_ECOLI pepwheel swissprot:MODF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MODF_ECOLI pepwindow swissprot:MODF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MODF_ECOLI sigcleave swissprot:MODF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MODF_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES pH dependence: Optimum pH is 7.0. {ECO 0000269|PubMed:1663113}; # BRENDA 2.7.8.B10 2026 # BioGrid 4260112 279 # CATALYTIC ACTIVITY CLSA_ECOLI 2 Phosphatidylglycerol = diphosphatidylglycerol + glycerol. {ECO 0000255|HAMAP- Rule MF_00190, ECO 0000269|PubMed 1663113, ECO 0000269|PubMed 19341704}. # DISRUPTION PHENOTYPE CLSA_ECOLI Mutants have increased sensitivity to novobiocin. Triple deletion of clsA, clsB and clsC results in a complete lack of cardiolipin, regardless of growth phase or growth conditions. {ECO 0000269|PubMed 19341704, ECO 0000269|PubMed 7665497}. # EcoGene EG11608 clsA # FUNCTION CLSA_ECOLI Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. {ECO 0000255|HAMAP-Rule MF_00190, ECO 0000269|PubMed 1663113, ECO 0000269|PubMed 19341704}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016020 membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0008808 cardiolipin synthase activity; IDA:EcoCyc. # GO_process GO:0032049 cardiolipin biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # HAMAP MF_00190 Cardiolipin_synth_ClsA # InterPro IPR001736 PLipase_D/transphosphatidylase # InterPro IPR022924 Cardiolipin_synthase # InterPro IPR025202 PLD-like_dom # InterPro IPR027379 CLS_N # InterPro IPR030840 CL_synthase_A # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00564 Glycerophospholipid metabolism # MISCELLANEOUS All three cardiolipin synthases (ClsA, ClsB and ClsC) contribute to CL synthesis in stationary phase. Only ClsA contributes to synthesis during logarithmic growth phase (PubMed:22988102). {ECO 0000305|PubMed:22988102}. # Organism CLSA_ECOLI Escherichia coli (strain K12) # PATRIC 32117758 VBIEscCol129921_1299 # PIR A56145 A56145 # PROSITE PS50035 PLD; 2 # PTM CLSA_ECOLI Seems to be post-translationally processed from a 53-55 kDa form to a 45-46 kDa form (PubMed 7665497 and PubMed 19341704). # Pfam PF13091 PLDc_2; 2 # Pfam PF13396 PLDc_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Cardiolipin synthase A {ECO:0000255|HAMAP-Rule MF_00190} # RefSeq NP_415765 NC_000913.3 # RefSeq WP_000214516 NZ_LN832404.1 # SIMILARITY Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily. {ECO:0000255|HAMAP- Rule MF_00190}. # SIMILARITY Contains 2 PLD phosphodiesterase domains. {ECO:0000255|HAMAP-Rule MF_00190}. # SMART SM00155 PLDc; 2 # SUBCELLULAR LOCATION CLSA_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_00190, ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 1663113, ECO 0000269|PubMed 22988102}; Multi- pass membrane protein {ECO 0000255|HAMAP-Rule MF_00190, ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 1663113, ECO 0000269|PubMed 22988102}. # TIGRFAMs TIGR04265 bac_cardiolipin # eggNOG COG1502 LUCA # eggNOG ENOG4105CQX Bacteria BLAST swissprot:CLSA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CLSA_ECOLI BioCyc ECOL316407:JW1241-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1241-MONOMER BioCyc EcoCyc:CARDIOLIPSYN-MONOMER http://biocyc.org/getid?id=EcoCyc:CARDIOLIPSYN-MONOMER BioCyc MetaCyc:CARDIOLIPSYN-MONOMER http://biocyc.org/getid?id=MetaCyc:CARDIOLIPSYN-MONOMER COG COG1502 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1502 DOI 10.1016/S0005-2760(97)00100-8 http://dx.doi.org/10.1016/S0005-2760(97)00100-8 DOI 10.1016/j.bbamem.2009.03.016 http://dx.doi.org/10.1016/j.bbamem.2009.03.016 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.1212797109 http://dx.doi.org/10.1073/pnas.1212797109 DOI 10.1073/pnas.91.9.3510 http://dx.doi.org/10.1073/pnas.91.9.3510 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.8.- {ECO:0000255|HAMAP-Rule:MF_00190} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.8.- {ECO:0000255|HAMAP-Rule:MF_00190} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D38779 http://www.ebi.ac.uk/ena/data/view/D38779 EMBL L12044 http://www.ebi.ac.uk/ena/data/view/L12044 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U01911 http://www.ebi.ac.uk/ena/data/view/U01911 EMBL U15986 http://www.ebi.ac.uk/ena/data/view/U15986 EMBL U24195 http://www.ebi.ac.uk/ena/data/view/U24195 EMBL U24196 http://www.ebi.ac.uk/ena/data/view/U24196 EMBL U24197 http://www.ebi.ac.uk/ena/data/view/U24197 EMBL U24198 http://www.ebi.ac.uk/ena/data/view/U24198 EMBL U24199 http://www.ebi.ac.uk/ena/data/view/U24199 EMBL U24200 http://www.ebi.ac.uk/ena/data/view/U24200 EMBL U24201 http://www.ebi.ac.uk/ena/data/view/U24201 EMBL U24202 http://www.ebi.ac.uk/ena/data/view/U24202 EMBL U24203 http://www.ebi.ac.uk/ena/data/view/U24203 EMBL U24204 http://www.ebi.ac.uk/ena/data/view/U24204 EMBL U24205 http://www.ebi.ac.uk/ena/data/view/U24205 EMBL U24206 http://www.ebi.ac.uk/ena/data/view/U24206 ENZYME 2.7.8.- {ECO:0000255|HAMAP-Rule:MF_00190} http://enzyme.expasy.org/EC/2.7.8.- {ECO:0000255|HAMAP-Rule:MF_00190} EchoBASE EB1565 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1565 EcoGene EG11608 http://www.ecogene.org/geneInfo.php?eg_id=EG11608 EnsemblBacteria AAC74331 http://www.ensemblgenomes.org/id/AAC74331 EnsemblBacteria AAC74331 http://www.ensemblgenomes.org/id/AAC74331 EnsemblBacteria BAA14781 http://www.ensemblgenomes.org/id/BAA14781 EnsemblBacteria BAA14781 http://www.ensemblgenomes.org/id/BAA14781 EnsemblBacteria BAA14781 http://www.ensemblgenomes.org/id/BAA14781 EnsemblBacteria b1249 http://www.ensemblgenomes.org/id/b1249 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008808 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008808 GO_process GO:0032049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032049 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 945821 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945821 HAMAP MF_00190 http://hamap.expasy.org/unirule/MF_00190 HOGENOM HOG000077403 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000077403&db=HOGENOM6 InParanoid P0A6H8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6H8 IntEnz 2.7.8.- {ECO:0000255|HAMAP-Rule:MF_00190} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.8.- {ECO:0000255|HAMAP-Rule:MF_00190} InterPro IPR001736 http://www.ebi.ac.uk/interpro/entry/IPR001736 InterPro IPR022924 http://www.ebi.ac.uk/interpro/entry/IPR022924 InterPro IPR025202 http://www.ebi.ac.uk/interpro/entry/IPR025202 InterPro IPR027379 http://www.ebi.ac.uk/interpro/entry/IPR027379 InterPro IPR030840 http://www.ebi.ac.uk/interpro/entry/IPR030840 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1241 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1241 KEGG_Gene eco:b1249 http://www.genome.jp/dbget-bin/www_bget?eco:b1249 KEGG_Orthology KO:K06131 http://www.genome.jp/dbget-bin/www_bget?KO:K06131 KEGG_Pathway ko00564 http://www.genome.jp/kegg-bin/show_pathway?ko00564 KEGG_Reaction rn:R02030 http://www.genome.jp/dbget-bin/www_bget?rn:R02030 KEGG_Reaction rn:R07390 http://www.genome.jp/dbget-bin/www_bget?rn:R07390 OMA FFKQDSG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FFKQDSG PROSITE PS50035 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50035 PSORT swissprot:CLSA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CLSA_ECOLI PSORT-B swissprot:CLSA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CLSA_ECOLI PSORT2 swissprot:CLSA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CLSA_ECOLI Pfam PF13091 http://pfam.xfam.org/family/PF13091 Pfam PF13396 http://pfam.xfam.org/family/PF13396 Phobius swissprot:CLSA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CLSA_ECOLI PhylomeDB P0A6H8 http://phylomedb.org/?seqid=P0A6H8 ProteinModelPortal P0A6H8 http://www.proteinmodelportal.org/query/uniprot/P0A6H8 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 1663113 http://www.ncbi.nlm.nih.gov/pubmed/1663113 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19341704 http://www.ncbi.nlm.nih.gov/pubmed/19341704 PubMed 22988102 http://www.ncbi.nlm.nih.gov/pubmed/22988102 PubMed 7665497 http://www.ncbi.nlm.nih.gov/pubmed/7665497 PubMed 7896699 http://www.ncbi.nlm.nih.gov/pubmed/7896699 PubMed 8170937 http://www.ncbi.nlm.nih.gov/pubmed/8170937 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9370333 http://www.ncbi.nlm.nih.gov/pubmed/9370333 RefSeq NP_415765 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415765 RefSeq WP_000214516 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000214516 SMART SM00155 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00155 SMR P0A6H8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6H8 STRING 511145.b1249 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1249&targetmode=cogs STRING COG1502 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1502&targetmode=cogs TIGRFAMs TIGR04265 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR04265 UniProtKB CLSA_ECOLI http://www.uniprot.org/uniprot/CLSA_ECOLI UniProtKB-AC P0A6H8 http://www.uniprot.org/uniprot/P0A6H8 charge swissprot:CLSA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CLSA_ECOLI eggNOG COG1502 http://eggnogapi.embl.de/nog_data/html/tree/COG1502 eggNOG ENOG4105CQX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CQX epestfind swissprot:CLSA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CLSA_ECOLI garnier swissprot:CLSA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CLSA_ECOLI helixturnhelix swissprot:CLSA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CLSA_ECOLI hmoment swissprot:CLSA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CLSA_ECOLI iep swissprot:CLSA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CLSA_ECOLI inforesidue swissprot:CLSA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CLSA_ECOLI octanol swissprot:CLSA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CLSA_ECOLI pepcoil swissprot:CLSA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CLSA_ECOLI pepdigest swissprot:CLSA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CLSA_ECOLI pepinfo swissprot:CLSA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CLSA_ECOLI pepnet swissprot:CLSA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CLSA_ECOLI pepstats swissprot:CLSA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CLSA_ECOLI pepwheel swissprot:CLSA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CLSA_ECOLI pepwindow swissprot:CLSA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CLSA_ECOLI sigcleave swissprot:CLSA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CLSA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261569 12 # EcoGene EG13562 ecpD # FUNCTION ECPD_ECOLI Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition. Tip pilus adhesin, which is required for assembly of EcpA into fibers (By similarity). {ECO 0000250}. # GO_component GO:0009289 pilus; IEA:UniProtKB-SubCell. # GOslim_component GO:0005575 cellular_component # INDUCTION Negatively regulated by H-NS. Positively regulated by IHF and EcpR (By similarity). {ECO 0000250}. # IntAct P77694 4 # MISCELLANEOUS Not expressed under classical laboratory conditions, but is functional when constitutively expressed. {ECO:0000305|PubMed 20522494}. # Organism ECPD_ECOLI Escherichia coli (strain K12) # PATRIC 32115703 VBIEscCol129921_0294 # PIR B64755 B64755 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ECPD_ECOLI Fimbria adhesin EcpD # RefSeq NP_414824 NC_000913.3 # RefSeq WP_001310578 NZ_LN832404.1 # SIMILARITY Belongs to the EcpD/MatE family. {ECO 0000305}. # SUBCELLULAR LOCATION ECPD_ECOLI Fimbrium {ECO 0000250}. # SUBUNIT Forms polymers. Interacts with EcpA. {ECO 0000250}. # eggNOG ENOG4106PYX Bacteria # eggNOG ENOG410YH0U LUCA BLAST swissprot:ECPD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ECPD_ECOLI BioCyc ECOL316407:JW0284-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0284-MONOMER BioCyc EcoCyc:G6161-MONOMER http://biocyc.org/getid?id=EcoCyc:G6161-MONOMER DIP DIP-11249N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11249N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1099/mic.0.039610-0 http://dx.doi.org/10.1099/mic.0.039610-0 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB3332 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3332 EcoGene EG13562 http://www.ecogene.org/geneInfo.php?eg_id=EG13562 EnsemblBacteria AAC73393 http://www.ensemblgenomes.org/id/AAC73393 EnsemblBacteria AAC73393 http://www.ensemblgenomes.org/id/AAC73393 EnsemblBacteria BAE76074 http://www.ensemblgenomes.org/id/BAE76074 EnsemblBacteria BAE76074 http://www.ensemblgenomes.org/id/BAE76074 EnsemblBacteria BAE76074 http://www.ensemblgenomes.org/id/BAE76074 EnsemblBacteria b0290 http://www.ensemblgenomes.org/id/b0290 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009289 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GeneID 947349 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947349 HOGENOM HOG000269468 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000269468&db=HOGENOM6 IntAct P77694 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77694* KEGG_Gene ecj:JW0284 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0284 KEGG_Gene eco:b0290 http://www.genome.jp/dbget-bin/www_bget?eco:b0290 MINT MINT-1311089 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1311089 OMA SRAGLSC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SRAGLSC PSORT swissprot:ECPD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ECPD_ECOLI PSORT-B swissprot:ECPD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ECPD_ECOLI PSORT2 swissprot:ECPD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ECPD_ECOLI Phobius swissprot:ECPD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ECPD_ECOLI ProteinModelPortal P77694 http://www.proteinmodelportal.org/query/uniprot/P77694 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20522494 http://www.ncbi.nlm.nih.gov/pubmed/20522494 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414824 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414824 RefSeq WP_001310578 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001310578 STRING 511145.b0290 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0290&targetmode=cogs UniProtKB ECPD_ECOLI http://www.uniprot.org/uniprot/ECPD_ECOLI UniProtKB-AC P77694 http://www.uniprot.org/uniprot/P77694 charge swissprot:ECPD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ECPD_ECOLI eggNOG ENOG4106PYX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106PYX eggNOG ENOG410YH0U http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YH0U epestfind swissprot:ECPD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ECPD_ECOLI garnier swissprot:ECPD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ECPD_ECOLI helixturnhelix swissprot:ECPD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ECPD_ECOLI hmoment swissprot:ECPD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ECPD_ECOLI iep swissprot:ECPD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ECPD_ECOLI inforesidue swissprot:ECPD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ECPD_ECOLI octanol swissprot:ECPD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ECPD_ECOLI pepcoil swissprot:ECPD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ECPD_ECOLI pepdigest swissprot:ECPD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ECPD_ECOLI pepinfo swissprot:ECPD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ECPD_ECOLI pepnet swissprot:ECPD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ECPD_ECOLI pepstats swissprot:ECPD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ECPD_ECOLI pepwheel swissprot:ECPD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ECPD_ECOLI pepwindow swissprot:ECPD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ECPD_ECOLI sigcleave swissprot:ECPD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ECPD_ECOLI ## Database ID URL or Descriptions # AltName Methyl-directed mismatch repair protein {ECO:0000255|HAMAP-Rule MF_00759} # BioGrid 4263275 194 # CDD cd00583 MutH_Sau3AI # EcoGene EG10624 mutH # FUNCTION MUTH_ECOLI Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_component GO:0032300 mismatch repair complex; IGI:EcoliWiki. # GO_function GO:0003677 DNA binding; IDA:EcoliWiki. # GO_function GO:0004519 endonuclease activity; IDA:EcoliWiki. # GO_function GO:0043765 T/G mismatch-specific endonuclease activity; IDA:EcoliWiki. # GO_process GO:0000018 regulation of DNA recombination; IMP:EcoliWiki. # GO_process GO:0006298 mismatch repair; IDA:EcoliWiki. # GO_process GO:0006304 DNA modification; IEA:InterPro. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004518 nuclease activity # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # Gene3D 3.40.600.10 -; 1. # HAMAP MF_00759 MutH # INTERACTION MUTH_ECOLI P23367 mutL; NbExp=8; IntAct=EBI-545170, EBI-554913; # IntAct P06722 10 # InterPro IPR004230 DNA_mismatch_repair_MutH # InterPro IPR011335 Restrct_endonuc-II-like # InterPro IPR011337 DNA_rep_MutH/RE_typeII # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko03430 Mismatch repair # Organism MUTH_ECOLI Escherichia coli (strain K12) # PATRIC 32121080 VBIEscCol129921_2929 # PDB 1AZO X-ray; 1.70 A; A=1-229 # PDB 2AZO X-ray; 2.30 A; A/B=1-229 # PIR H65065 MVECMH # Pfam PF02976 MutH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DNA mismatch repair protein MutH {ECO:0000255|HAMAP-Rule MF_00759} # RefSeq NP_417308 NC_000913.3 # RefSeq WP_000082201 NZ_LN832404.1 # SIMILARITY Belongs to the MutH family. {ECO:0000255|HAMAP- Rule MF_00759}. # SMART SM00927 MutH # SUBCELLULAR LOCATION MUTH_ECOLI Cytoplasm. # SUPFAM SSF52980 SSF52980 # TIGRFAMs TIGR02248 mutH_TIGR # eggNOG COG3066 LUCA # eggNOG ENOG4105IRT Bacteria BLAST swissprot:MUTH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MUTH_ECOLI BioCyc ECOL316407:JW2799-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2799-MONOMER BioCyc EcoCyc:EG10624-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10624-MONOMER BioCyc MetaCyc:EG10624-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10624-MONOMER COG COG3066 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3066 DIP DIP-10284N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10284N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/emboj/17.5.1526 http://dx.doi.org/10.1093/emboj/17.5.1526 DOI 10.1093/nar/15.7.3073 http://dx.doi.org/10.1093/nar/15.7.3073 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AJ005726 http://www.ebi.ac.uk/ena/data/view/AJ005726 EMBL AJ005727 http://www.ebi.ac.uk/ena/data/view/AJ005727 EMBL AJ005728 http://www.ebi.ac.uk/ena/data/view/AJ005728 EMBL AJ005729 http://www.ebi.ac.uk/ena/data/view/AJ005729 EMBL AJ005730 http://www.ebi.ac.uk/ena/data/view/AJ005730 EMBL AJ005731 http://www.ebi.ac.uk/ena/data/view/AJ005731 EMBL AJ005732 http://www.ebi.ac.uk/ena/data/view/AJ005732 EMBL AJ005733 http://www.ebi.ac.uk/ena/data/view/AJ005733 EMBL AJ005734 http://www.ebi.ac.uk/ena/data/view/AJ005734 EMBL AJ005735 http://www.ebi.ac.uk/ena/data/view/AJ005735 EMBL AJ005736 http://www.ebi.ac.uk/ena/data/view/AJ005736 EMBL AJ005737 http://www.ebi.ac.uk/ena/data/view/AJ005737 EMBL AJ005738 http://www.ebi.ac.uk/ena/data/view/AJ005738 EMBL AJ005739 http://www.ebi.ac.uk/ena/data/view/AJ005739 EMBL AJ005740 http://www.ebi.ac.uk/ena/data/view/AJ005740 EMBL AJ005743 http://www.ebi.ac.uk/ena/data/view/AJ005743 EMBL AJ005744 http://www.ebi.ac.uk/ena/data/view/AJ005744 EMBL AJ005745 http://www.ebi.ac.uk/ena/data/view/AJ005745 EMBL AJ005746 http://www.ebi.ac.uk/ena/data/view/AJ005746 EMBL AJ005747 http://www.ebi.ac.uk/ena/data/view/AJ005747 EMBL AJ005748 http://www.ebi.ac.uk/ena/data/view/AJ005748 EMBL AJ005749 http://www.ebi.ac.uk/ena/data/view/AJ005749 EMBL AJ005750 http://www.ebi.ac.uk/ena/data/view/AJ005750 EMBL AJ005751 http://www.ebi.ac.uk/ena/data/view/AJ005751 EMBL AJ005752 http://www.ebi.ac.uk/ena/data/view/AJ005752 EMBL AJ005753 http://www.ebi.ac.uk/ena/data/view/AJ005753 EMBL AJ005755 http://www.ebi.ac.uk/ena/data/view/AJ005755 EMBL AJ238719 http://www.ebi.ac.uk/ena/data/view/AJ238719 EMBL AJ238720 http://www.ebi.ac.uk/ena/data/view/AJ238720 EMBL AJ238721 http://www.ebi.ac.uk/ena/data/view/AJ238721 EMBL AJ238722 http://www.ebi.ac.uk/ena/data/view/AJ238722 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U16361 http://www.ebi.ac.uk/ena/data/view/U16361 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 EMBL Y00113 http://www.ebi.ac.uk/ena/data/view/Y00113 EchoBASE EB0619 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0619 EcoGene EG10624 http://www.ecogene.org/geneInfo.php?eg_id=EG10624 EnsemblBacteria AAC75870 http://www.ensemblgenomes.org/id/AAC75870 EnsemblBacteria AAC75870 http://www.ensemblgenomes.org/id/AAC75870 EnsemblBacteria BAE76900 http://www.ensemblgenomes.org/id/BAE76900 EnsemblBacteria BAE76900 http://www.ensemblgenomes.org/id/BAE76900 EnsemblBacteria BAE76900 http://www.ensemblgenomes.org/id/BAE76900 EnsemblBacteria b2831 http://www.ensemblgenomes.org/id/b2831 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0032300 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032300 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004519 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004519 GO_function GO:0043765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043765 GO_process GO:0000018 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000018 GO_process GO:0006298 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006298 GO_process GO:0006304 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006304 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.600.10 http://www.cathdb.info/version/latest/superfamily/3.40.600.10 GeneID 947299 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947299 HAMAP MF_00759 http://hamap.expasy.org/unirule/MF_00759 IntAct P06722 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P06722* InterPro IPR004230 http://www.ebi.ac.uk/interpro/entry/IPR004230 InterPro IPR011335 http://www.ebi.ac.uk/interpro/entry/IPR011335 InterPro IPR011337 http://www.ebi.ac.uk/interpro/entry/IPR011337 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW2799 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2799 KEGG_Gene eco:b2831 http://www.genome.jp/dbget-bin/www_bget?eco:b2831 KEGG_Orthology KO:K03573 http://www.genome.jp/dbget-bin/www_bget?KO:K03573 KEGG_Pathway ko03430 http://www.genome.jp/kegg-bin/show_pathway?ko03430 MINT MINT-1542547 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1542547 OMA VMQLRPK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VMQLRPK PDB 1AZO http://www.ebi.ac.uk/pdbe-srv/view/entry/1AZO PDB 2AZO http://www.ebi.ac.uk/pdbe-srv/view/entry/2AZO PDBsum 1AZO http://www.ebi.ac.uk/pdbsum/1AZO PDBsum 2AZO http://www.ebi.ac.uk/pdbsum/2AZO PSORT swissprot:MUTH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MUTH_ECOLI PSORT-B swissprot:MUTH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MUTH_ECOLI PSORT2 swissprot:MUTH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MUTH_ECOLI Pfam PF02976 http://pfam.xfam.org/family/PF02976 Phobius swissprot:MUTH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MUTH_ECOLI ProteinModelPortal P06722 http://www.proteinmodelportal.org/query/uniprot/P06722 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3031619 http://www.ncbi.nlm.nih.gov/pubmed/3031619 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9482749 http://www.ncbi.nlm.nih.gov/pubmed/9482749 RefSeq NP_417308 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417308 RefSeq WP_000082201 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000082201 SMART SM00927 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00927 SMR P06722 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P06722 STRING 511145.b2831 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2831&targetmode=cogs STRING COG3066 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3066&targetmode=cogs SUPFAM SSF52980 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52980 TIGRFAMs TIGR02248 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02248 UniProtKB MUTH_ECOLI http://www.uniprot.org/uniprot/MUTH_ECOLI UniProtKB-AC P06722 http://www.uniprot.org/uniprot/P06722 charge swissprot:MUTH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MUTH_ECOLI eggNOG COG3066 http://eggnogapi.embl.de/nog_data/html/tree/COG3066 eggNOG ENOG4105IRT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105IRT epestfind swissprot:MUTH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MUTH_ECOLI garnier swissprot:MUTH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MUTH_ECOLI helixturnhelix swissprot:MUTH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MUTH_ECOLI hmoment swissprot:MUTH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MUTH_ECOLI iep swissprot:MUTH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MUTH_ECOLI inforesidue swissprot:MUTH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MUTH_ECOLI octanol swissprot:MUTH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MUTH_ECOLI pepcoil swissprot:MUTH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MUTH_ECOLI pepdigest swissprot:MUTH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MUTH_ECOLI pepinfo swissprot:MUTH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MUTH_ECOLI pepnet swissprot:MUTH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MUTH_ECOLI pepstats swissprot:MUTH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MUTH_ECOLI pepwheel swissprot:MUTH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MUTH_ECOLI pepwindow swissprot:MUTH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MUTH_ECOLI sigcleave swissprot:MUTH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MUTH_ECOLI ## Database ID URL or Descriptions # BioGrid 4260803 184 # EcoGene EG13394 yfhM # GO_component GO:0031362 anchored component of external side of plasma membrane; IDA:EcoCyc. # GO_function GO:0004866 endopeptidase inhibitor activity; IDA:EcoCyc. # GO_process GO:0010951 negative regulation of endopeptidase activity; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0030234 enzyme regulator activity # GOslim_process GO:0008150 biological_process # Gene3D 1.50.10.20 -; 1. # IntAct P76578 15 # InterPro IPR001599 Macroglobln_a2 # InterPro IPR002890 A2M_N # InterPro IPR008930 Terpenoid_cyclase/PrenylTrfase # InterPro IPR011625 A2M_N_2 # InterPro IPR021868 Alpha_2_Macroglob_MG1 # InterPro IPR026284 A2-macglob_dom_prot_bac # Organism YFHM_ECOLI Escherichia coli (strain K12) # PATRIC 32120433 VBIEscCol129921_2619 # PDB 4RTD X-ray; 3.65 A; A=23-1653 # PDB 4ZIQ X-ray; 2.55 A; A=40-1653 # PDB 4ZIU X-ray; 2.70 A; A=1018-1653 # PDB 4ZJG X-ray; 2.30 A; A=40-385 # PDB 4ZJH X-ray; 1.60 A; A=163-368 # PDB 5A42 EM; 16.00 A; A=40-1653 # PIR G65028 G65028 # PIRSF PIRSF038980 A2M_bac # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF00207 A2M # Pfam PF01835 A2M_N # Pfam PF07703 A2M_N_2 # Pfam PF11974 MG1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFHM_ECOLI Uncharacterized lipoprotein YfhM # RefSeq NP_417015 NC_000913.3 # RefSeq WP_000736312 NZ_LN832404.1 # SMART SM01359 A2M_N_2 # SMART SM01360 A2M # SUBCELLULAR LOCATION YFHM_ECOLI Cell membrane {ECO 0000255|PROSITE- ProRule PRU00303}; Lipid-anchor {ECO 0000255|PROSITE- ProRule PRU00303}. # SUPFAM SSF48239 SSF48239 # eggNOG COG2373 LUCA # eggNOG ENOG4105DN3 Bacteria BLAST swissprot:YFHM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFHM_ECOLI BioCyc ECOL316407:JW2504-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2504-MONOMER BioCyc EcoCyc:G7323-MONOMER http://biocyc.org/getid?id=EcoCyc:G7323-MONOMER COG COG2373 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2373 DIP DIP-28064N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-28064N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3175 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3175 EcoGene EG13394 http://www.ecogene.org/geneInfo.php?eg_id=EG13394 EnsemblBacteria AAC75573 http://www.ensemblgenomes.org/id/AAC75573 EnsemblBacteria AAC75573 http://www.ensemblgenomes.org/id/AAC75573 EnsemblBacteria BAE76729 http://www.ensemblgenomes.org/id/BAE76729 EnsemblBacteria BAE76729 http://www.ensemblgenomes.org/id/BAE76729 EnsemblBacteria BAE76729 http://www.ensemblgenomes.org/id/BAE76729 EnsemblBacteria b2520 http://www.ensemblgenomes.org/id/b2520 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0031362 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031362 GO_function GO:0004866 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004866 GO_process GO:0010951 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010951 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.50.10.20 http://www.cathdb.info/version/latest/superfamily/1.50.10.20 GeneID 947302 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947302 HOGENOM HOG000275932 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275932&db=HOGENOM6 InParanoid P76578 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76578 IntAct P76578 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76578* InterPro IPR001599 http://www.ebi.ac.uk/interpro/entry/IPR001599 InterPro IPR002890 http://www.ebi.ac.uk/interpro/entry/IPR002890 InterPro IPR008930 http://www.ebi.ac.uk/interpro/entry/IPR008930 InterPro IPR011625 http://www.ebi.ac.uk/interpro/entry/IPR011625 InterPro IPR021868 http://www.ebi.ac.uk/interpro/entry/IPR021868 InterPro IPR026284 http://www.ebi.ac.uk/interpro/entry/IPR026284 KEGG_Gene ecj:JW2504 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2504 KEGG_Gene eco:b2520 http://www.genome.jp/dbget-bin/www_bget?eco:b2520 KEGG_Orthology KO:K06894 http://www.genome.jp/dbget-bin/www_bget?KO:K06894 OMA TAYAMDF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TAYAMDF PDB 4RTD http://www.ebi.ac.uk/pdbe-srv/view/entry/4RTD PDB 4ZIQ http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZIQ PDB 4ZIU http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZIU PDB 4ZJG http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZJG PDB 4ZJH http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZJH PDB 5A42 http://www.ebi.ac.uk/pdbe-srv/view/entry/5A42 PDBsum 4RTD http://www.ebi.ac.uk/pdbsum/4RTD PDBsum 4ZIQ http://www.ebi.ac.uk/pdbsum/4ZIQ PDBsum 4ZIU http://www.ebi.ac.uk/pdbsum/4ZIU PDBsum 4ZJG http://www.ebi.ac.uk/pdbsum/4ZJG PDBsum 4ZJH http://www.ebi.ac.uk/pdbsum/4ZJH PDBsum 5A42 http://www.ebi.ac.uk/pdbsum/5A42 PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YFHM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFHM_ECOLI PSORT-B swissprot:YFHM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFHM_ECOLI PSORT2 swissprot:YFHM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFHM_ECOLI Pfam PF00207 http://pfam.xfam.org/family/PF00207 Pfam PF01835 http://pfam.xfam.org/family/PF01835 Pfam PF07703 http://pfam.xfam.org/family/PF07703 Pfam PF11974 http://pfam.xfam.org/family/PF11974 Phobius swissprot:YFHM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFHM_ECOLI PhylomeDB P76578 http://phylomedb.org/?seqid=P76578 ProteinModelPortal P76578 http://www.proteinmodelportal.org/query/uniprot/P76578 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417015 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417015 RefSeq WP_000736312 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000736312 SMART SM01359 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01359 SMART SM01360 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01360 SMR P76578 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76578 STRING 511145.b2520 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2520&targetmode=cogs STRING COG2373 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2373&targetmode=cogs SUPFAM SSF48239 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48239 UniProtKB YFHM_ECOLI http://www.uniprot.org/uniprot/YFHM_ECOLI UniProtKB-AC P76578 http://www.uniprot.org/uniprot/P76578 charge swissprot:YFHM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFHM_ECOLI eggNOG COG2373 http://eggnogapi.embl.de/nog_data/html/tree/COG2373 eggNOG ENOG4105DN3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DN3 epestfind swissprot:YFHM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFHM_ECOLI garnier swissprot:YFHM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFHM_ECOLI helixturnhelix swissprot:YFHM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFHM_ECOLI hmoment swissprot:YFHM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFHM_ECOLI iep swissprot:YFHM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFHM_ECOLI inforesidue swissprot:YFHM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFHM_ECOLI octanol swissprot:YFHM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFHM_ECOLI pepcoil swissprot:YFHM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFHM_ECOLI pepdigest swissprot:YFHM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFHM_ECOLI pepinfo swissprot:YFHM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFHM_ECOLI pepnet swissprot:YFHM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFHM_ECOLI pepstats swissprot:YFHM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFHM_ECOLI pepwheel swissprot:YFHM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFHM_ECOLI pepwindow swissprot:YFHM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFHM_ECOLI sigcleave swissprot:YFHM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFHM_ECOLI ## Database ID URL or Descriptions # AltName Spheroplast protein Y {ECO:0000303|PubMed 9068658} # BioGrid 4262237 141 # CDD cd09916 CpxP_like # DEVELOPMENTAL STAGE Produced abundantly in spheroplasts, not detected in intact cells. {ECO:0000269|PubMed 9068658}. # DISRUPTION PHENOTYPE SPY_ECOLI No observed growth phenotype (PubMed 9068658). Increased levels of degP and rpoH transcription; may induce the sigma factor E regulon (rpoE) (PubMed 10972835). Loss of about 50% of periplasmic alkaline phosphatase activity; very sensitive to tannic acid (PubMed 21317898). {ECO 0000269|PubMed 10972835, ECO 0000269|PubMed 21317898, ECO 0000269|PubMed 9068658}. # DOMAIN SPY_ECOLI Has an elongated cradle shape. {ECO 0000250|UniProtKB Q8XDZ4, ECO 0000305|PubMed 24497545}. # EcoGene EG13490 spy # FUNCTION SPY_ECOLI An ATP-independent periplasmic chaperone, decreases protein aggregation and helps protein refolding. Binds substrate over a large region of its convex inner surface (PubMed 21317898, PubMed 24497545). Substrate protein folds while it is bound to chaperone (PubMed 26619265). Increasing Spy flexibility increases its substrate affinity and overall chaperone activity (shown for 3 different substrates) (PubMed 24497545). Protects proteins in vitro against tannin inactivation; tannins have antimicrobial activity (PubMed 21317898). Overexpression enhances the stability of otherwise unstable periplasmic proteins (PubMed 21317898). {ECO 0000269|PubMed 21317898, ECO 0000269|PubMed 24497545, ECO 0000269|PubMed 26619265}. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_process GO:0061077 chaperone-mediated protein folding; IDA:EcoCyc. # GO_process GO:1990507 ATP-independent chaperone mediated protein folding; IDA:UniProtKB. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0006457 protein folding # INDUCTION SPY_ECOLI Induced by many sorts of periplasmic stress. Produced upon spheroplast formation, not induced by growth in 0.5 M sucrose or 0.35 M NaCl, nor by mutants that have a leaky periplasmic space (at protein level) (PubMed 9068658). Induction is partially dependent on the Cpx envelope stress response encoded by cpxA- cpxR; does not depend on sigma factor E (rpoE) (PubMed 10972835). Induction is also partially dependent on the Bae envelope stress response encoded by baeS-baeR; cpx and baeS effects are independent (PubMed 12354228). Overexpression of P pili protein PapG induces spy expression via both Cpx and Bae, overexpression of outer membrane protein NlpE induces spy via only Cpx whereas indole induces spy expression only via Bae (PubMed 12354228). Induced by 1 mM zinc (at protein level) (PubMed 9694902), via Bae, which also regulates ethanol induction of spy (PubMed 24999585). Induced by copper via Cpx (PubMed 24999585). Induced by tannic acid (to 25% of total periplasmic protein), butanol (to 20% total periplasmic protein) and ethanol (to 5% total periplasmic protein) (at protein level) (PubMed 21317898). {ECO 0000269|PubMed 10972835, ECO 0000269|PubMed 12354228, ECO 0000269|PubMed 21317898, ECO 0000269|PubMed 24999585, ECO 0000269|PubMed 9068658, ECO 0000269|PubMed 9694902}. # IntAct P77754 2 # InterPro IPR012899 LTXXQ # Organism SPY_ECOLI Escherichia coli (strain K12) # PATRIC 32118795 VBIEscCol129921_1815 # PDB 5INA X-ray; 1.79 A; A/B=52-147 # PDB 5IOA X-ray; 1.87 A; A/B=52-147 # PDB 5IOE X-ray; 1.87 A; A/B=52-147 # PDB 5IOG X-ray; 1.77 A; A/B=52-147 # PIR G64933 G64933 # PIRSF PIRSF034445 CpxP_Spy # Pfam PF07813 LTXXQ # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Periplasmic chaperone Spy {ECO:0000303|PubMed 21317898} # RefSeq NP_416257 NC_000913.3 # RefSeq WP_001228984 NZ_LN832404.1 # SIMILARITY Belongs to the CpxP/Spy family. {ECO 0000305}. # SUBCELLULAR LOCATION SPY_ECOLI Periplasm {ECO 0000269|PubMed 21317898, ECO 0000269|PubMed 9068658, ECO 0000269|PubMed 9694902}. # SUBUNIT Homodimer. {ECO:0000250|UniProtKB Q8XDZ4}. # eggNOG COG3678 LUCA # eggNOG ENOG4108SPG Bacteria BLAST swissprot:SPY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SPY_ECOLI BioCyc ECOL316407:JW1732-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1732-MONOMER BioCyc EcoCyc:G6939-MONOMER http://biocyc.org/getid?id=EcoCyc:G6939-MONOMER DIP DIP-10914N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10914N DOI 10.1016/j.gene.2014.07.003 http://dx.doi.org/10.1016/j.gene.2014.07.003 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsmb.2016 http://dx.doi.org/10.1038/nsmb.2016 DOI 10.1038/nsmb.3133 http://dx.doi.org/10.1038/nsmb.3133 DOI 10.1046/j.1365-2958.2000.02074.x http://dx.doi.org/10.1046/j.1365-2958.2000.02074.x DOI 10.1046/j.1365-2958.2002.03112.x http://dx.doi.org/10.1046/j.1365-2958.2002.03112.x DOI 10.1074/jbc.273.33.21393 http://dx.doi.org/10.1074/jbc.273.33.21393 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.7554/eLife.01584 http://dx.doi.org/10.7554/eLife.01584 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL Y07714 http://www.ebi.ac.uk/ena/data/view/Y07714 EchoBASE EB3263 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3263 EcoGene EG13490 http://www.ecogene.org/geneInfo.php?eg_id=EG13490 EnsemblBacteria AAC74813 http://www.ensemblgenomes.org/id/AAC74813 EnsemblBacteria AAC74813 http://www.ensemblgenomes.org/id/AAC74813 EnsemblBacteria BAA15531 http://www.ensemblgenomes.org/id/BAA15531 EnsemblBacteria BAA15531 http://www.ensemblgenomes.org/id/BAA15531 EnsemblBacteria BAA15531 http://www.ensemblgenomes.org/id/BAA15531 EnsemblBacteria b1743 http://www.ensemblgenomes.org/id/b1743 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_process GO:0061077 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061077 GO_process GO:1990507 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990507 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GeneID 946253 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946253 HOGENOM HOG000285733 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000285733&db=HOGENOM6 InParanoid P77754 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77754 IntAct P77754 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77754* InterPro IPR012899 http://www.ebi.ac.uk/interpro/entry/IPR012899 KEGG_Gene ecj:JW1732 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1732 KEGG_Gene eco:b1743 http://www.genome.jp/dbget-bin/www_bget?eco:b1743 OMA KMYNLLT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KMYNLLT PDB 5INA http://www.ebi.ac.uk/pdbe-srv/view/entry/5INA PDB 5IOA http://www.ebi.ac.uk/pdbe-srv/view/entry/5IOA PDB 5IOE http://www.ebi.ac.uk/pdbe-srv/view/entry/5IOE PDB 5IOG http://www.ebi.ac.uk/pdbe-srv/view/entry/5IOG PDBsum 5INA http://www.ebi.ac.uk/pdbsum/5INA PDBsum 5IOA http://www.ebi.ac.uk/pdbsum/5IOA PDBsum 5IOE http://www.ebi.ac.uk/pdbsum/5IOE PDBsum 5IOG http://www.ebi.ac.uk/pdbsum/5IOG PSORT swissprot:SPY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SPY_ECOLI PSORT-B swissprot:SPY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SPY_ECOLI PSORT2 swissprot:SPY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SPY_ECOLI Pfam PF07813 http://pfam.xfam.org/family/PF07813 Phobius swissprot:SPY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SPY_ECOLI PhylomeDB P77754 http://phylomedb.org/?seqid=P77754 ProteinModelPortal P77754 http://www.proteinmodelportal.org/query/uniprot/P77754 PubMed 10972835 http://www.ncbi.nlm.nih.gov/pubmed/10972835 PubMed 12354228 http://www.ncbi.nlm.nih.gov/pubmed/12354228 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21317898 http://www.ncbi.nlm.nih.gov/pubmed/21317898 PubMed 24497545 http://www.ncbi.nlm.nih.gov/pubmed/24497545 PubMed 24999585 http://www.ncbi.nlm.nih.gov/pubmed/24999585 PubMed 26619265 http://www.ncbi.nlm.nih.gov/pubmed/26619265 PubMed 9068658 http://www.ncbi.nlm.nih.gov/pubmed/9068658 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9694902 http://www.ncbi.nlm.nih.gov/pubmed/9694902 RefSeq NP_416257 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416257 RefSeq WP_001228984 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001228984 SMR P77754 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77754 STRING 511145.b1743 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1743&targetmode=cogs UniProtKB SPY_ECOLI http://www.uniprot.org/uniprot/SPY_ECOLI UniProtKB-AC P77754 http://www.uniprot.org/uniprot/P77754 charge swissprot:SPY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SPY_ECOLI eggNOG COG3678 http://eggnogapi.embl.de/nog_data/html/tree/COG3678 eggNOG ENOG4108SPG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108SPG epestfind swissprot:SPY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SPY_ECOLI garnier swissprot:SPY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SPY_ECOLI helixturnhelix swissprot:SPY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SPY_ECOLI hmoment swissprot:SPY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SPY_ECOLI iep swissprot:SPY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SPY_ECOLI inforesidue swissprot:SPY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SPY_ECOLI octanol swissprot:SPY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SPY_ECOLI pepcoil swissprot:SPY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SPY_ECOLI pepdigest swissprot:SPY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SPY_ECOLI pepinfo swissprot:SPY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SPY_ECOLI pepnet swissprot:SPY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SPY_ECOLI pepstats swissprot:SPY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SPY_ECOLI pepwheel swissprot:SPY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SPY_ECOLI pepwindow swissprot:SPY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SPY_ECOLI sigcleave swissprot:SPY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SPY_ECOLI ## Database ID URL or Descriptions # BioGrid 4261271 6 # ENZYME REGULATION LLDP_ECOLI Inhibited by carbonyl cyanide m- chlorophenylhydrazone (CCCP). # EcoGene EG11961 lldP # FUNCTION LLDP_ECOLI Transports L-lactate across the membrane. Can also transport D-lactate and glycolate. Seems to be driven by a proton motive force. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoliWiki. # GO_function GO:0015129 lactate transmembrane transporter activity; IEA:InterPro. # GO_function LLDP_ECOLI GO 0015295 solute proton symporter activity; IDA EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006950 response to stress # INDUCTION LLDP_ECOLI By L-lactate; aerobically. # InterPro IPR003804 Lactate_perm # Organism LLDP_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30003 PTHR30003 # PATRIC 32122691 VBIEscCol129921_3722 # PIR A49904 A49904 # Pfam PF02652 Lactate_perm # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LLDP_ECOLI L-lactate permease # RefSeq NP_418060 NC_000913.3 # RefSeq WP_001295233 NZ_LN832404.1 # SIMILARITY Belongs to the lactate permease family. {ECO 0000305}. # SUBCELLULAR LOCATION LLDP_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # TCDB 2.A.14.1 the lactate permease (lctp) family # TIGRFAMs TIGR00795 lctP # eggNOG COG1620 LUCA # eggNOG ENOG4105DAA Bacteria BLAST swissprot:LLDP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LLDP_ECOLI BioCyc ECOL316407:JW3578-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3578-MONOMER BioCyc EcoCyc:LCTP-MONOMER http://biocyc.org/getid?id=EcoCyc:LCTP-MONOMER BioCyc MetaCyc:LCTP-MONOMER http://biocyc.org/getid?id=MetaCyc:LCTP-MONOMER COG COG1620 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1620 DIP DIP-10109N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10109N DOI 10.1006/bbrc.2001.6255 http://dx.doi.org/10.1006/bbrc.2001.6255 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L13970 http://www.ebi.ac.uk/ena/data/view/L13970 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1904 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1904 EcoGene EG11961 http://www.ecogene.org/geneInfo.php?eg_id=EG11961 EnsemblBacteria AAC76627 http://www.ensemblgenomes.org/id/AAC76627 EnsemblBacteria AAC76627 http://www.ensemblgenomes.org/id/AAC76627 EnsemblBacteria BAE77689 http://www.ensemblgenomes.org/id/BAE77689 EnsemblBacteria BAE77689 http://www.ensemblgenomes.org/id/BAE77689 EnsemblBacteria BAE77689 http://www.ensemblgenomes.org/id/BAE77689 EnsemblBacteria b3603 http://www.ensemblgenomes.org/id/b3603 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015129 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015129 GO_function GO:0015295 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015295 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 948114 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948114 HOGENOM HOG000253321 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000253321&db=HOGENOM6 InParanoid P33231 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33231 IntAct P33231 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33231* InterPro IPR003804 http://www.ebi.ac.uk/interpro/entry/IPR003804 KEGG_Gene ecj:JW3578 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3578 KEGG_Gene eco:b3603 http://www.genome.jp/dbget-bin/www_bget?eco:b3603 KEGG_Orthology KO:K00427 http://www.genome.jp/dbget-bin/www_bget?KO:K00427 MINT MINT-1233464 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1233464 OMA MSEFHQV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MSEFHQV PANTHER PTHR30003 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30003 PSORT swissprot:LLDP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LLDP_ECOLI PSORT-B swissprot:LLDP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LLDP_ECOLI PSORT2 swissprot:LLDP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LLDP_ECOLI Pfam PF02652 http://pfam.xfam.org/family/PF02652 Phobius swissprot:LLDP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LLDP_ECOLI PhylomeDB P33231 http://phylomedb.org/?seqid=P33231 ProteinModelPortal P33231 http://www.proteinmodelportal.org/query/uniprot/P33231 PubMed 11283302 http://www.ncbi.nlm.nih.gov/pubmed/11283302 PubMed 11785976 http://www.ncbi.nlm.nih.gov/pubmed/11785976 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 8407843 http://www.ncbi.nlm.nih.gov/pubmed/8407843 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418060 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418060 RefSeq WP_001295233 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295233 STRING 511145.b3603 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3603&targetmode=cogs STRING COG1620 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1620&targetmode=cogs TCDB 2.A.14.1 http://www.tcdb.org/search/result.php?tc=2.A.14.1 TIGRFAMs TIGR00795 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00795 UniProtKB LLDP_ECOLI http://www.uniprot.org/uniprot/LLDP_ECOLI UniProtKB-AC P33231 http://www.uniprot.org/uniprot/P33231 charge swissprot:LLDP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LLDP_ECOLI eggNOG COG1620 http://eggnogapi.embl.de/nog_data/html/tree/COG1620 eggNOG ENOG4105DAA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DAA epestfind swissprot:LLDP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LLDP_ECOLI garnier swissprot:LLDP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LLDP_ECOLI helixturnhelix swissprot:LLDP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LLDP_ECOLI hmoment swissprot:LLDP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LLDP_ECOLI iep swissprot:LLDP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LLDP_ECOLI inforesidue swissprot:LLDP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LLDP_ECOLI octanol swissprot:LLDP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LLDP_ECOLI pepcoil swissprot:LLDP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LLDP_ECOLI pepdigest swissprot:LLDP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LLDP_ECOLI pepinfo swissprot:LLDP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LLDP_ECOLI pepnet swissprot:LLDP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LLDP_ECOLI pepstats swissprot:LLDP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LLDP_ECOLI pepwheel swissprot:LLDP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LLDP_ECOLI pepwindow swissprot:LLDP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LLDP_ECOLI sigcleave swissprot:LLDP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LLDP_ECOLI ## Database ID URL or Descriptions # BioGrid 4262513 8 # EcoGene EG11767 yhhJ # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0015562 efflux transmembrane transporter activity; IBA:GO_Central. # GO_process GO:0055085 transmembrane transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0055085 transmembrane transport # InterPro IPR000412 ABC_2_transport # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00248 Putative antibiotic transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism YHHJ_ECOLI Escherichia coli (strain K12) # PATRIC 32122414 VBIEscCol129921_3584 # PROSITE PS51012 ABC_TM2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHHJ_ECOLI Inner membrane transport permease YhhJ # RefSeq NP_417942 NC_000913.3 # RefSeq WP_001216257 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18460.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ABC-2 integral membrane protein family. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-2 domain. {ECO:0000255|PROSITE-ProRule PRU00442}. # SUBCELLULAR LOCATION YHHJ_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 3.A.1.105.16 the atp-binding cassette (abc) superfamily # eggNOG COG0842 LUCA # eggNOG ENOG4105CMI Bacteria BLAST swissprot:YHHJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHHJ_ECOLI BioCyc ECOL316407:JW5677-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5677-MONOMER BioCyc EcoCyc:YHHJ-MONOMER http://biocyc.org/getid?id=EcoCyc:YHHJ-MONOMER COG COG0842 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0842 COG COG1277 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1277 COG COG1668 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1668 COG COG3559 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3559 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L02370 http://www.ebi.ac.uk/ena/data/view/L02370 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1717 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1717 EcoGene EG11767 http://www.ecogene.org/geneInfo.php?eg_id=EG11767 EnsemblBacteria AAC76510 http://www.ensemblgenomes.org/id/AAC76510 EnsemblBacteria AAC76510 http://www.ensemblgenomes.org/id/AAC76510 EnsemblBacteria BAE77808 http://www.ensemblgenomes.org/id/BAE77808 EnsemblBacteria BAE77808 http://www.ensemblgenomes.org/id/BAE77808 EnsemblBacteria BAE77808 http://www.ensemblgenomes.org/id/BAE77808 EnsemblBacteria b3485 http://www.ensemblgenomes.org/id/b3485 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015562 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015562 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 947991 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947991 HOGENOM HOG000270978 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000270978&db=HOGENOM6 InParanoid P0AGH1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGH1 InterPro IPR000412 http://www.ebi.ac.uk/interpro/entry/IPR000412 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5677 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5677 KEGG_Gene eco:b3485 http://www.genome.jp/dbget-bin/www_bget?eco:b3485 KEGG_Orthology KO:K09686 http://www.genome.jp/dbget-bin/www_bget?KO:K09686 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA IFMGTLA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IFMGTLA PROSITE PS51012 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51012 PSORT swissprot:YHHJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHHJ_ECOLI PSORT-B swissprot:YHHJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHHJ_ECOLI PSORT2 swissprot:YHHJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHHJ_ECOLI Phobius swissprot:YHHJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHHJ_ECOLI PhylomeDB P0AGH1 http://phylomedb.org/?seqid=P0AGH1 ProteinModelPortal P0AGH1 http://www.proteinmodelportal.org/query/uniprot/P0AGH1 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 8387990 http://www.ncbi.nlm.nih.gov/pubmed/8387990 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417942 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417942 RefSeq WP_001216257 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001216257 STRING 511145.b3485 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3485&targetmode=cogs STRING COG0842 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0842&targetmode=cogs STRING COG1277 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1277&targetmode=cogs STRING COG1668 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1668&targetmode=cogs STRING COG3559 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3559&targetmode=cogs TCDB 3.A.1.105.16 http://www.tcdb.org/search/result.php?tc=3.A.1.105.16 UniProtKB YHHJ_ECOLI http://www.uniprot.org/uniprot/YHHJ_ECOLI UniProtKB-AC P0AGH1 http://www.uniprot.org/uniprot/P0AGH1 charge swissprot:YHHJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHHJ_ECOLI eggNOG COG0842 http://eggnogapi.embl.de/nog_data/html/tree/COG0842 eggNOG ENOG4105CMI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CMI epestfind swissprot:YHHJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHHJ_ECOLI garnier swissprot:YHHJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHHJ_ECOLI helixturnhelix swissprot:YHHJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHHJ_ECOLI hmoment swissprot:YHHJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHHJ_ECOLI iep swissprot:YHHJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHHJ_ECOLI inforesidue swissprot:YHHJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHHJ_ECOLI octanol swissprot:YHHJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHHJ_ECOLI pepcoil swissprot:YHHJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHHJ_ECOLI pepdigest swissprot:YHHJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHHJ_ECOLI pepinfo swissprot:YHHJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHHJ_ECOLI pepnet swissprot:YHHJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHHJ_ECOLI pepstats swissprot:YHHJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHHJ_ECOLI pepwheel swissprot:YHHJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHHJ_ECOLI pepwindow swissprot:YHHJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHHJ_ECOLI sigcleave swissprot:YHHJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHHJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4262164 16 # EcoGene EG13591 yahG # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # Gene3D 1.10.10.660 -; 1. # IntAct P77221 10 # InterPro IPR009499 DUF1116 # InterPro IPR024033 Uncharacterised_dom_YlbE # Organism YAHG_ECOLI Escherichia coli (strain K12) # PATRIC 32115771 VBIEscCol129921_0328 # PIR A64759 A64759 # Pfam PF06545 DUF1116 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAHG_ECOLI Uncharacterized protein YahG # RefSeq NP_414855 NC_000913.3 # RefSeq WP_000083429 NZ_LN832404.1 # SIMILARITY To E.coli YlbE. {ECO 0000305}. # SUBCELLULAR LOCATION YAHG_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # eggNOG ENOG4107REC Bacteria # eggNOG ENOG410XPNV LUCA BLAST swissprot:YAHG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAHG_ECOLI BioCyc ECOL316407:JW0313-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0313-MONOMER BioCyc EcoCyc:G6186-MONOMER http://biocyc.org/getid?id=EcoCyc:G6186-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB3361 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3361 EcoGene EG13591 http://www.ecogene.org/geneInfo.php?eg_id=EG13591 EnsemblBacteria AAC73424 http://www.ensemblgenomes.org/id/AAC73424 EnsemblBacteria AAC73424 http://www.ensemblgenomes.org/id/AAC73424 EnsemblBacteria BAE76104 http://www.ensemblgenomes.org/id/BAE76104 EnsemblBacteria BAE76104 http://www.ensemblgenomes.org/id/BAE76104 EnsemblBacteria BAE76104 http://www.ensemblgenomes.org/id/BAE76104 EnsemblBacteria b0321 http://www.ensemblgenomes.org/id/b0321 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 Gene3D 1.10.10.660 http://www.cathdb.info/version/latest/superfamily/1.10.10.660 GeneID 945379 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945379 HOGENOM HOG000077993 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000077993&db=HOGENOM6 IntAct P77221 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77221* InterPro IPR009499 http://www.ebi.ac.uk/interpro/entry/IPR009499 InterPro IPR024033 http://www.ebi.ac.uk/interpro/entry/IPR024033 KEGG_Gene ecj:JW0313 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0313 KEGG_Gene eco:b0321 http://www.genome.jp/dbget-bin/www_bget?eco:b0321 OMA TNLSEQM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TNLSEQM PSORT swissprot:YAHG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAHG_ECOLI PSORT-B swissprot:YAHG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAHG_ECOLI PSORT2 swissprot:YAHG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAHG_ECOLI Pfam PF06545 http://pfam.xfam.org/family/PF06545 Phobius swissprot:YAHG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAHG_ECOLI ProteinModelPortal P77221 http://www.proteinmodelportal.org/query/uniprot/P77221 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414855 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414855 RefSeq WP_000083429 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000083429 SMR P77221 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77221 STRING 511145.b0321 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0321&targetmode=cogs UniProtKB YAHG_ECOLI http://www.uniprot.org/uniprot/YAHG_ECOLI UniProtKB-AC P77221 http://www.uniprot.org/uniprot/P77221 charge swissprot:YAHG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAHG_ECOLI eggNOG ENOG4107REC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107REC eggNOG ENOG410XPNV http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPNV epestfind swissprot:YAHG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAHG_ECOLI garnier swissprot:YAHG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAHG_ECOLI helixturnhelix swissprot:YAHG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAHG_ECOLI hmoment swissprot:YAHG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAHG_ECOLI iep swissprot:YAHG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAHG_ECOLI inforesidue swissprot:YAHG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAHG_ECOLI octanol swissprot:YAHG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAHG_ECOLI pepcoil swissprot:YAHG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAHG_ECOLI pepdigest swissprot:YAHG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAHG_ECOLI pepinfo swissprot:YAHG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAHG_ECOLI pepnet swissprot:YAHG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAHG_ECOLI pepstats swissprot:YAHG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAHG_ECOLI pepwheel swissprot:YAHG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAHG_ECOLI pepwindow swissprot:YAHG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAHG_ECOLI sigcleave swissprot:YAHG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAHG_ECOLI ## Database ID URL or Descriptions # AltName DGAL_ECOLI D-galactose/ D-glucose-binding protein # BioGrid 4259172 12 # DOMAIN DGAL_ECOLI The calcium-binding site is structurally similar to that of EF-hand proteins, but is in two parts, with the last calcium ligand provided by Glu-228. # EcoGene EG10593 mglB # FUNCTION DGAL_ECOLI This protein is involved in the active transport of galactose and glucose. It plays a role in the chemotaxis towards the two sugars by interacting with the trg chemoreceptor. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006935 chemotaxis; IEA:UniProtKB-KW. # GO_process GO:0008643 carbohydrate transport; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # GOslim_process GO:0040011 locomotion # IntAct P0AEE5 8 # InterPro IPR025997 SBP_2_dom # InterPro IPR028082 Peripla_BP_I # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00214 Methyl-galactoside transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # KEGG_Pathway ko02030 Bacterial chemotaxis # Organism DGAL_ECOLI Escherichia coli (strain K12) # PATRIC 32119645 VBIEscCol129921_2233 # PDB 1GLG X-ray; 2.00 A; A=24-332 # PDB 2FVY X-ray; 0.92 A; A=24-332 # PDB 2FW0 X-ray; 1.55 A; A=24-332 # PDB 2GBP X-ray; 1.90 A; A=24-332 # PDB 2HPH X-ray; 1.33 A; A=24-332 # PDB 2IPL X-ray; 1.20 A; A=24-332 # PDB 2IPM X-ray; 1.12 A; A=24-332 # PDB 2IPN X-ray; 1.15 A; A=24-332 # PDB 2QW1 X-ray; 1.70 A; A=24-332 # PIR A37277 JGECG # Pfam PF13407 Peripla_BP_4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DGAL_ECOLI D-galactose-binding periplasmic protein # RefSeq NP_416655 NC_000913.3 # RefSeq WP_001036964 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial solute-binding protein 2 family. {ECO 0000305}. # SUBCELLULAR LOCATION DGAL_ECOLI Periplasm. # SUPFAM SSF53822 SSF53822 # TCDB 3.A.1.2 the atp-binding cassette (abc) superfamily # eggNOG COG1879 LUCA # eggNOG ENOG4105EMA Bacteria BLAST swissprot:DGAL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DGAL_ECOLI BioCyc ECOL316407:JW2137-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2137-MONOMER BioCyc EcoCyc:MGLB-MONOMER http://biocyc.org/getid?id=EcoCyc:MGLB-MONOMER BioCyc MetaCyc:MGLB-MONOMER http://biocyc.org/getid?id=MetaCyc:MGLB-MONOMER COG COG1879 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1879 DIP DIP-35953N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35953N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1007/BF00267469 http://dx.doi.org/10.1007/BF00267469 DOI 10.1007/BF00330450 http://dx.doi.org/10.1007/BF00330450 DOI 10.1038/327635a0 http://dx.doi.org/10.1038/327635a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.80.7.1792 http://dx.doi.org/10.1073/pnas.80.7.1792 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1126/science.3057628 http://dx.doi.org/10.1126/science.3057628 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K00419 http://www.ebi.ac.uk/ena/data/view/K00419 EMBL M59444 http://www.ebi.ac.uk/ena/data/view/M59444 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X05646 http://www.ebi.ac.uk/ena/data/view/X05646 EchoBASE EB0588 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0588 EcoGene EG10593 http://www.ecogene.org/geneInfo.php?eg_id=EG10593 EnsemblBacteria AAC75211 http://www.ensemblgenomes.org/id/AAC75211 EnsemblBacteria AAC75211 http://www.ensemblgenomes.org/id/AAC75211 EnsemblBacteria BAE76627 http://www.ensemblgenomes.org/id/BAE76627 EnsemblBacteria BAE76627 http://www.ensemblgenomes.org/id/BAE76627 EnsemblBacteria BAE76627 http://www.ensemblgenomes.org/id/BAE76627 EnsemblBacteria b2150 http://www.ensemblgenomes.org/id/b2150 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006935 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006935 GO_process GO:0008643 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008643 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0040011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011 GeneID 949041 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949041 HOGENOM HOG000212345 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000212345&db=HOGENOM6 InParanoid P0AEE5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEE5 IntAct P0AEE5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEE5* InterPro IPR025997 http://www.ebi.ac.uk/interpro/entry/IPR025997 InterPro IPR028082 http://www.ebi.ac.uk/interpro/entry/IPR028082 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2137 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2137 KEGG_Gene eco:b2150 http://www.genome.jp/dbget-bin/www_bget?eco:b2150 KEGG_Orthology KO:K10540 http://www.genome.jp/dbget-bin/www_bget?KO:K10540 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 KEGG_Pathway ko02030 http://www.genome.jp/kegg-bin/show_pathway?ko02030 MINT MINT-1274707 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1274707 OMA AMWDTAM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AMWDTAM PDB 1GLG http://www.ebi.ac.uk/pdbe-srv/view/entry/1GLG PDB 2FVY http://www.ebi.ac.uk/pdbe-srv/view/entry/2FVY PDB 2FW0 http://www.ebi.ac.uk/pdbe-srv/view/entry/2FW0 PDB 2GBP http://www.ebi.ac.uk/pdbe-srv/view/entry/2GBP PDB 2HPH http://www.ebi.ac.uk/pdbe-srv/view/entry/2HPH PDB 2IPL http://www.ebi.ac.uk/pdbe-srv/view/entry/2IPL PDB 2IPM http://www.ebi.ac.uk/pdbe-srv/view/entry/2IPM PDB 2IPN http://www.ebi.ac.uk/pdbe-srv/view/entry/2IPN PDB 2QW1 http://www.ebi.ac.uk/pdbe-srv/view/entry/2QW1 PDBsum 1GLG http://www.ebi.ac.uk/pdbsum/1GLG PDBsum 2FVY http://www.ebi.ac.uk/pdbsum/2FVY PDBsum 2FW0 http://www.ebi.ac.uk/pdbsum/2FW0 PDBsum 2GBP http://www.ebi.ac.uk/pdbsum/2GBP PDBsum 2HPH http://www.ebi.ac.uk/pdbsum/2HPH PDBsum 2IPL http://www.ebi.ac.uk/pdbsum/2IPL PDBsum 2IPM http://www.ebi.ac.uk/pdbsum/2IPM PDBsum 2IPN http://www.ebi.ac.uk/pdbsum/2IPN PDBsum 2QW1 http://www.ebi.ac.uk/pdbsum/2QW1 PSORT swissprot:DGAL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DGAL_ECOLI PSORT-B swissprot:DGAL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DGAL_ECOLI PSORT2 swissprot:DGAL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DGAL_ECOLI Pfam PF13407 http://pfam.xfam.org/family/PF13407 Phobius swissprot:DGAL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DGAL_ECOLI PhylomeDB P0AEE5 http://phylomedb.org/?seqid=P0AEE5 ProteinModelPortal P0AEE5 http://www.proteinmodelportal.org/query/uniprot/P0AEE5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1719366 http://www.ncbi.nlm.nih.gov/pubmed/1719366 PubMed 3057628 http://www.ncbi.nlm.nih.gov/pubmed/3057628 PubMed 3302609 http://www.ncbi.nlm.nih.gov/pubmed/3302609 PubMed 3600760 http://www.ncbi.nlm.nih.gov/pubmed/3600760 PubMed 6340108 http://www.ncbi.nlm.nih.gov/pubmed/6340108 PubMed 6885805 http://www.ncbi.nlm.nih.gov/pubmed/6885805 PubMed 7012152 http://www.ncbi.nlm.nih.gov/pubmed/7012152 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_416655 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416655 RefSeq WP_001036964 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001036964 SMR P0AEE5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEE5 STRING 511145.b2150 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2150&targetmode=cogs STRING COG1879 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1879&targetmode=cogs SUPFAM SSF53822 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822 SWISS-2DPAGE P0AEE5 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AEE5 TCDB 3.A.1.2 http://www.tcdb.org/search/result.php?tc=3.A.1.2 UniProtKB DGAL_ECOLI http://www.uniprot.org/uniprot/DGAL_ECOLI UniProtKB-AC P0AEE5 http://www.uniprot.org/uniprot/P0AEE5 charge swissprot:DGAL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DGAL_ECOLI eggNOG COG1879 http://eggnogapi.embl.de/nog_data/html/tree/COG1879 eggNOG ENOG4105EMA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EMA epestfind swissprot:DGAL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DGAL_ECOLI garnier swissprot:DGAL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DGAL_ECOLI helixturnhelix swissprot:DGAL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DGAL_ECOLI hmoment swissprot:DGAL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DGAL_ECOLI iep swissprot:DGAL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DGAL_ECOLI inforesidue swissprot:DGAL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DGAL_ECOLI octanol swissprot:DGAL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DGAL_ECOLI pepcoil swissprot:DGAL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DGAL_ECOLI pepdigest swissprot:DGAL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DGAL_ECOLI pepinfo swissprot:DGAL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DGAL_ECOLI pepnet swissprot:DGAL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DGAL_ECOLI pepstats swissprot:DGAL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DGAL_ECOLI pepwheel swissprot:DGAL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DGAL_ECOLI pepwindow swissprot:DGAL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DGAL_ECOLI sigcleave swissprot:DGAL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DGAL_ECOLI ## Database ID URL or Descriptions # AltName NAD(P)H:quinone oxidoreductase {ECO 0000255|HAMAP-Rule:MF_01017} # AltName NQOR_ECOLI Flavoprotein WrbA # BIOPHYSICOCHEMICAL PROPERTIES NQOR_ECOLI Kinetic parameters KM=5.8 uM for benzoquinone {ECO 0000269|PubMed 16672604}; KM=14 uM for NADH {ECO 0000269|PubMed 16672604}; # BRENDA 1.6.5 2026 # BioGrid 4259550 7 # CATALYTIC ACTIVITY NQOR_ECOLI NAD(P)H + a quinone = NAD(P)(+) + a hydroquinone. {ECO 0000255|HAMAP-Rule MF_01017, ECO 0000269|PubMed 16672604}. # CAUTION Was originally (PubMed:9694845) thought to enhance the formation and/or stability of non-covalent complexes between the trp repressor protein and operator-bearing DNA. However, WrbA does not specifically influence the affinity or mode of binding of TrpR to its operator. {ECO 0000305|PubMed:9694845}. # COFACTOR NQOR_ECOLI Name=FMN; Xref=ChEBI CHEBI 58210; Evidence={ECO 0000255|HAMAP-Rule MF_01017, ECO 0000269|PubMed 16672604, ECO 0000269|PubMed 9694845}; Note=Binds 1 FMN per monomer. {ECO 0000255|HAMAP-Rule MF_01017, ECO 0000269|PubMed 16672604, ECO 0000269|PubMed 9694845}; # DISRUPTION PHENOTYPE Cells lacking this gene show no phenotypes, however, N-trichloromethyl-mercapto-4-cyclohexene-1,2- dicarboximide and 8-hydroxyquinoline significantly inhibit the growth of the wrbA knockout relative to the wild-type, which is consistent with a role for WrbA in protecting against environmental stressors through its quinone reductase activity. {ECO:0000269|PubMed 17209564}. # EcoGene EG11540 wrbA # FUNCTION NQOR_ECOLI It seems to function in response to environmental stress when various electron transfer chains are affected or when the environment is highly oxidizing. It reduces quinones to the hydroquinone state to prevent interaction of the semiquinone with O2 and production of superoxide. It prefers NADH over NADPH. {ECO 0000269|PubMed 16672604, ECO 0000269|PubMed 9694845}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005886 plasma membrane; IBA:GO_Central. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0003955 NAD(P)H dehydrogenase (quinone) activity; IDA:EcoCyc. # GO_function GO:0010181 FMN binding; IDA:EcoCyc. # GO_function GO:0050660 flavin adenine dinucleotide binding; IEA:UniProtKB-HAMAP. # GO_function GO:0050661 NADP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0051287 NAD binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006979 response to oxidative stress; IEP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # Gene3D 3.40.50.360 -; 1. # HAMAP MF_01017 NQOR # INTERACTION NQOR_ECOLI Self; NbExp=2; IntAct=EBI-553971, EBI-553971; # IntAct P0A8G6 4 # InterPro IPR005025 FMN_Rdtase-like # InterPro IPR008254 Flavodoxin/NO_synth # InterPro IPR010089 Flavoprotein_WrbA # InterPro IPR029039 Flavoprotein-like_dom # MISCELLANEOUS FMN promotes WrbA association into tetramers, which are more thermoresistant than dimers or monomers, suggesting that multimerization underlies the FMN effect on WrbA thermostability. {ECO:0000305|PubMed 9694845}. # Organism NQOR_ECOLI Escherichia coli (strain K12) # PATRIC 32117233 VBIEscCol129921_1040 # PDB 2R96 X-ray; 2.60 A; A/C=1-198 # PDB 2R97 X-ray; 2.00 A; A/C=1-198 # PDB 2RG1 X-ray; 1.85 A; A/B=1-198 # PDB 3B6I X-ray; 1.66 A; A/B=1-198 # PDB 3B6J X-ray; 2.05 A; A/B=1-198 # PDB 3B6K X-ray; 1.99 A; A/B=1-198 # PDB 3B6M X-ray; 1.85 A; A/B=1-198 # PDB 3ZHO X-ray; 1.20 A; A/B=2-198 # PDB 4YQE X-ray; 1.33 A; A/B=2-198 # PDB 5F12 X-ray; 1.50 A; A/B=2-198 # PIR B64842 B64842 # PROSITE PS50902 FLAVODOXIN_LIKE # Pfam PF03358 FMN_red # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NAD(P)H dehydrogenase (quinone) {ECO:0000255|HAMAP-Rule MF_01017} # RefSeq NP_415524 NC_000913.3 # RefSeq WP_001151437 NZ_LN832404.1 # SIMILARITY Belongs to the WrbA family. {ECO:0000255|HAMAP- Rule MF_01017, ECO:0000305}. # SIMILARITY Contains 1 flavodoxin-like domain. {ECO:0000255|HAMAP- Rule MF_01017}. # SUBUNIT NQOR_ECOLI Homodimer and homotetramer; in equilibrium. {ECO 0000269|PubMed 17209564, ECO 0000269|PubMed 17951395, ECO 0000269|PubMed 19665595, ECO 0000269|PubMed 9694845}. # SUPFAM SSF52218 SSF52218 # TIGRFAMs TIGR01755 flav_wrbA # eggNOG COG0655 LUCA # eggNOG ENOG4105CS1 Bacteria BLAST swissprot:NQOR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NQOR_ECOLI BioCyc ECOL316407:JW0989-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0989-MONOMER BioCyc EcoCyc:PD01343 http://biocyc.org/getid?id=EcoCyc:PD01343 BioCyc MetaCyc:PD01343 http://biocyc.org/getid?id=MetaCyc:PD01343 COG COG0655 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0655 DIP DIP-36231N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36231N DOI 10.1016/j.bbapap.2009.08.001 http://dx.doi.org/10.1016/j.bbapap.2009.08.001 DOI 10.1021/bi061769c http://dx.doi.org/10.1021/bi061769c DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.90.12.5796 http://dx.doi.org/10.1073/pnas.90.12.5796 DOI 10.1074/jbc.273.33.20960 http://dx.doi.org/10.1074/jbc.273.33.20960 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01336-07 http://dx.doi.org/10.1128/JB.01336-07 DOI 10.1128/JB.188.10.3498-3506.2006 http://dx.doi.org/10.1128/JB.188.10.3498-3506.2006 EC_number EC:1.6.5.2 {ECO:0000255|HAMAP-Rule:MF_01017, ECO:0000269|PubMed:16672604} http://www.genome.jp/dbget-bin/www_bget?EC:1.6.5.2 {ECO:0000255|HAMAP-Rule:MF_01017, ECO:0000269|PubMed:16672604} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M99166 http://www.ebi.ac.uk/ena/data/view/M99166 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.6.5.2 {ECO:0000255|HAMAP-Rule:MF_01017, ECO:0000269|PubMed:16672604} http://enzyme.expasy.org/EC/1.6.5.2 {ECO:0000255|HAMAP-Rule:MF_01017, ECO:0000269|PubMed:16672604} EchoBASE EB1502 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1502 EcoGene EG11540 http://www.ecogene.org/geneInfo.php?eg_id=EG11540 EnsemblBacteria AAC74089 http://www.ensemblgenomes.org/id/AAC74089 EnsemblBacteria AAC74089 http://www.ensemblgenomes.org/id/AAC74089 EnsemblBacteria BAA35771 http://www.ensemblgenomes.org/id/BAA35771 EnsemblBacteria BAA35771 http://www.ensemblgenomes.org/id/BAA35771 EnsemblBacteria BAA35771 http://www.ensemblgenomes.org/id/BAA35771 EnsemblBacteria b1004 http://www.ensemblgenomes.org/id/b1004 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0003955 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003955 GO_function GO:0010181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010181 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_function GO:0050661 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050661 GO_function GO:0051287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051287 GO_process GO:0006979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.40.50.360 http://www.cathdb.info/version/latest/superfamily/3.40.50.360 GeneID 947263 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947263 HAMAP MF_01017 http://hamap.expasy.org/unirule/MF_01017 HOGENOM HOG000030539 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000030539&db=HOGENOM6 InParanoid P0A8G6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8G6 IntAct P0A8G6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8G6* IntEnz 1.6.5.2 {ECO:0000255|HAMAP-Rule:MF_01017, ECO:0000269|PubMed:16672604} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.6.5.2 {ECO:0000255|HAMAP-Rule:MF_01017, ECO:0000269|PubMed:16672604} InterPro IPR005025 http://www.ebi.ac.uk/interpro/entry/IPR005025 InterPro IPR008254 http://www.ebi.ac.uk/interpro/entry/IPR008254 InterPro IPR010089 http://www.ebi.ac.uk/interpro/entry/IPR010089 InterPro IPR029039 http://www.ebi.ac.uk/interpro/entry/IPR029039 KEGG_Gene ecj:JW0989 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0989 KEGG_Gene eco:b1004 http://www.genome.jp/dbget-bin/www_bget?eco:b1004 KEGG_Orthology KO:K03809 http://www.genome.jp/dbget-bin/www_bget?KO:K03809 MINT MINT-1272067 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1272067 OMA WMKGALV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WMKGALV PDB 2R96 http://www.ebi.ac.uk/pdbe-srv/view/entry/2R96 PDB 2R97 http://www.ebi.ac.uk/pdbe-srv/view/entry/2R97 PDB 2RG1 http://www.ebi.ac.uk/pdbe-srv/view/entry/2RG1 PDB 3B6I http://www.ebi.ac.uk/pdbe-srv/view/entry/3B6I PDB 3B6J http://www.ebi.ac.uk/pdbe-srv/view/entry/3B6J PDB 3B6K http://www.ebi.ac.uk/pdbe-srv/view/entry/3B6K PDB 3B6M http://www.ebi.ac.uk/pdbe-srv/view/entry/3B6M PDB 3ZHO http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZHO PDB 4YQE http://www.ebi.ac.uk/pdbe-srv/view/entry/4YQE PDB 5F12 http://www.ebi.ac.uk/pdbe-srv/view/entry/5F12 PDBsum 2R96 http://www.ebi.ac.uk/pdbsum/2R96 PDBsum 2R97 http://www.ebi.ac.uk/pdbsum/2R97 PDBsum 2RG1 http://www.ebi.ac.uk/pdbsum/2RG1 PDBsum 3B6I http://www.ebi.ac.uk/pdbsum/3B6I PDBsum 3B6J http://www.ebi.ac.uk/pdbsum/3B6J PDBsum 3B6K http://www.ebi.ac.uk/pdbsum/3B6K PDBsum 3B6M http://www.ebi.ac.uk/pdbsum/3B6M PDBsum 3ZHO http://www.ebi.ac.uk/pdbsum/3ZHO PDBsum 4YQE http://www.ebi.ac.uk/pdbsum/4YQE PDBsum 5F12 http://www.ebi.ac.uk/pdbsum/5F12 PROSITE PS50902 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50902 PSORT swissprot:NQOR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NQOR_ECOLI PSORT-B swissprot:NQOR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NQOR_ECOLI PSORT2 swissprot:NQOR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NQOR_ECOLI Pfam PF03358 http://pfam.xfam.org/family/PF03358 Phobius swissprot:NQOR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NQOR_ECOLI PhylomeDB P0A8G6 http://phylomedb.org/?seqid=P0A8G6 ProteinModelPortal P0A8G6 http://www.proteinmodelportal.org/query/uniprot/P0A8G6 PubMed 16672604 http://www.ncbi.nlm.nih.gov/pubmed/16672604 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17209564 http://www.ncbi.nlm.nih.gov/pubmed/17209564 PubMed 17951395 http://www.ncbi.nlm.nih.gov/pubmed/17951395 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 19665595 http://www.ncbi.nlm.nih.gov/pubmed/19665595 PubMed 8516330 http://www.ncbi.nlm.nih.gov/pubmed/8516330 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9694845 http://www.ncbi.nlm.nih.gov/pubmed/9694845 RefSeq NP_415524 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415524 RefSeq WP_001151437 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001151437 SMR P0A8G6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8G6 STRING 511145.b1004 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1004&targetmode=cogs STRING COG0655 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0655&targetmode=cogs SUPFAM SSF52218 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52218 SWISS-2DPAGE P0A8G6 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A8G6 TIGRFAMs TIGR01755 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01755 UniProtKB NQOR_ECOLI http://www.uniprot.org/uniprot/NQOR_ECOLI UniProtKB-AC P0A8G6 http://www.uniprot.org/uniprot/P0A8G6 charge swissprot:NQOR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NQOR_ECOLI eggNOG COG0655 http://eggnogapi.embl.de/nog_data/html/tree/COG0655 eggNOG ENOG4105CS1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CS1 epestfind swissprot:NQOR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NQOR_ECOLI garnier swissprot:NQOR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NQOR_ECOLI helixturnhelix swissprot:NQOR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NQOR_ECOLI hmoment swissprot:NQOR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NQOR_ECOLI iep swissprot:NQOR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NQOR_ECOLI inforesidue swissprot:NQOR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NQOR_ECOLI octanol swissprot:NQOR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NQOR_ECOLI pepcoil swissprot:NQOR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NQOR_ECOLI pepdigest swissprot:NQOR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NQOR_ECOLI pepinfo swissprot:NQOR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NQOR_ECOLI pepnet swissprot:NQOR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NQOR_ECOLI pepstats swissprot:NQOR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NQOR_ECOLI pepwheel swissprot:NQOR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NQOR_ECOLI pepwindow swissprot:NQOR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NQOR_ECOLI sigcleave swissprot:NQOR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NQOR_ECOLI ## Database ID URL or Descriptions # AltName L-ascorbate utilization protein F {ECO:0000255|HAMAP-Rule MF_01952} # AltName Phosphoribulose isomerase {ECO:0000255|HAMAP-Rule MF_01952} # BioGrid 4262716 6 # CATALYTIC ACTIVITY L-ribulose 5-phosphate = D-xylulose 5- phosphate. {ECO:0000255|HAMAP-Rule MF_01952}. # COFACTOR ULAF_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000255|HAMAP-Rule MF_01952}; Note=Binds 1 zinc ion per subunit. {ECO 0000255|HAMAP- Rule MF_01952}; # EcoGene EG12498 ulaF # FUNCTION ULAF_ECOLI Catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate. Is involved in the anaerobic L-ascorbate utilization. {ECO 0000255|HAMAP-Rule MF_01952, ECO 0000269|PubMed 11741871}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0008270 zinc ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008742 L-ribulose-phosphate 4-epimerase activity; IDA:EcoCyc. # GO_function GO:0016832 aldehyde-lyase activity; IBA:GO_Central. # GO_process GO:0019323 pentose catabolic process; IBA:GO_Central. # GO_process GO:0019852 L-ascorbic acid metabolic process; IEP:EcoCyc. # GO_process GO:0019854 L-ascorbic acid catabolic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.225.10 -; 1. # HAMAP MF_01952 UlaF # INDUCTION ULAF_ECOLI Induced by L-ascorbate. Repressed by UlaR. {ECO 0000255|HAMAP-Rule MF_01952, ECO 0000269|PubMed 12374842, ECO 0000269|PubMed 14996803}. # IntAct P39306 12 # InterPro IPR001303 Aldolase_II/adducin_N # InterPro IPR023499 UlaF # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00053 Ascorbate and aldarate metabolism # Organism ULAF_ECOLI Escherichia coli (strain K12) # PATHWAY Cofactor degradation; L-ascorbate degradation; D-xylulose 5-phosphate from L-ascorbate: step 4/4. {ECO 0000255|HAMAP- Rule:MF_01952}. # PATRIC 32123971 VBIEscCol129921_4330 # PIR S56423 S56423 # Pfam PF00596 Aldolase_II # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName L-ribulose-5-phosphate 4-epimerase UlaF {ECO:0000255|HAMAP-Rule MF_01952} # RefSeq NP_418619 NC_000913.3 # RefSeq WP_001170847 NZ_LN832404.1 # SIMILARITY Belongs to the aldolase class II family. AraD/FucA subfamily. {ECO:0000255|HAMAP-Rule MF_01952}. # SMART SM01007 Aldolase_II # SUPFAM SSF53639 SSF53639 # UniPathway UPA00263 UER00380 # eggNOG COG0235 LUCA # eggNOG ENOG4107R0P Bacteria BLAST swissprot:ULAF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ULAF_ECOLI BioCyc ECOL316407:JW4156-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4156-MONOMER BioCyc EcoCyc:G7860-MONOMER http://biocyc.org/getid?id=EcoCyc:G7860-MONOMER BioCyc MetaCyc:G7860-MONOMER http://biocyc.org/getid?id=MetaCyc:G7860-MONOMER COG COG0235 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0235 DIP DIP-10868N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10868N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.1.302-306.2002 http://dx.doi.org/10.1128/JB.184.1.302-306.2002 DOI 10.1128/JB.184.21.6065-6068.2002 http://dx.doi.org/10.1128/JB.184.21.6065-6068.2002 DOI 10.1128/JB.186.6.1720-1728.2004 http://dx.doi.org/10.1128/JB.186.6.1720-1728.2004 EC_number EC:5.1.3.4 {ECO:0000255|HAMAP-Rule:MF_01952} http://www.genome.jp/dbget-bin/www_bget?EC:5.1.3.4 {ECO:0000255|HAMAP-Rule:MF_01952} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 5.1.3.4 {ECO:0000255|HAMAP-Rule:MF_01952} http://enzyme.expasy.org/EC/5.1.3.4 {ECO:0000255|HAMAP-Rule:MF_01952} EchoBASE EB2391 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2391 EcoGene EG12498 http://www.ecogene.org/geneInfo.php?eg_id=EG12498 EnsemblBacteria AAC77155 http://www.ensemblgenomes.org/id/AAC77155 EnsemblBacteria AAC77155 http://www.ensemblgenomes.org/id/AAC77155 EnsemblBacteria BAE78199 http://www.ensemblgenomes.org/id/BAE78199 EnsemblBacteria BAE78199 http://www.ensemblgenomes.org/id/BAE78199 EnsemblBacteria BAE78199 http://www.ensemblgenomes.org/id/BAE78199 EnsemblBacteria b4198 http://www.ensemblgenomes.org/id/b4198 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0008742 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008742 GO_function GO:0016832 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016832 GO_process GO:0019323 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019323 GO_process GO:0019852 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019852 GO_process GO:0019854 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019854 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.225.10 http://www.cathdb.info/version/latest/superfamily/3.40.225.10 GeneID 948711 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948711 HAMAP MF_01952 http://hamap.expasy.org/unirule/MF_01952 HOGENOM HOG000218183 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218183&db=HOGENOM6 InParanoid P39306 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39306 IntAct P39306 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39306* IntEnz 5.1.3.4 {ECO:0000255|HAMAP-Rule:MF_01952} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.1.3.4 {ECO:0000255|HAMAP-Rule:MF_01952} InterPro IPR001303 http://www.ebi.ac.uk/interpro/entry/IPR001303 InterPro IPR023499 http://www.ebi.ac.uk/interpro/entry/IPR023499 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4156 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4156 KEGG_Gene eco:b4198 http://www.genome.jp/dbget-bin/www_bget?eco:b4198 KEGG_Orthology KO:K03077 http://www.genome.jp/dbget-bin/www_bget?KO:K03077 KEGG_Pathway ko00053 http://www.genome.jp/kegg-bin/show_pathway?ko00053 KEGG_Reaction rn:R05850 http://www.genome.jp/dbget-bin/www_bget?rn:R05850 MINT MINT-1288465 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1288465 OMA PNIGTTH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PNIGTTH PSORT swissprot:ULAF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ULAF_ECOLI PSORT-B swissprot:ULAF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ULAF_ECOLI PSORT2 swissprot:ULAF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ULAF_ECOLI Pfam PF00596 http://pfam.xfam.org/family/PF00596 Phobius swissprot:ULAF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ULAF_ECOLI PhylomeDB P39306 http://phylomedb.org/?seqid=P39306 ProteinModelPortal P39306 http://www.proteinmodelportal.org/query/uniprot/P39306 PubMed 11741871 http://www.ncbi.nlm.nih.gov/pubmed/11741871 PubMed 12374842 http://www.ncbi.nlm.nih.gov/pubmed/12374842 PubMed 14996803 http://www.ncbi.nlm.nih.gov/pubmed/14996803 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418619 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418619 RefSeq WP_001170847 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001170847 SMART SM01007 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01007 SMR P39306 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39306 STRING 511145.b4198 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4198&targetmode=cogs STRING COG0235 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0235&targetmode=cogs SUPFAM SSF53639 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53639 UniProtKB ULAF_ECOLI http://www.uniprot.org/uniprot/ULAF_ECOLI UniProtKB-AC P39306 http://www.uniprot.org/uniprot/P39306 charge swissprot:ULAF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ULAF_ECOLI eggNOG COG0235 http://eggnogapi.embl.de/nog_data/html/tree/COG0235 eggNOG ENOG4107R0P http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107R0P epestfind swissprot:ULAF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ULAF_ECOLI garnier swissprot:ULAF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ULAF_ECOLI helixturnhelix swissprot:ULAF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ULAF_ECOLI hmoment swissprot:ULAF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ULAF_ECOLI iep swissprot:ULAF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ULAF_ECOLI inforesidue swissprot:ULAF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ULAF_ECOLI octanol swissprot:ULAF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ULAF_ECOLI pepcoil swissprot:ULAF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ULAF_ECOLI pepdigest swissprot:ULAF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ULAF_ECOLI pepinfo swissprot:ULAF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ULAF_ECOLI pepnet swissprot:ULAF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ULAF_ECOLI pepstats swissprot:ULAF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ULAF_ECOLI pepwheel swissprot:ULAF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ULAF_ECOLI pepwindow swissprot:ULAF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ULAF_ECOLI sigcleave swissprot:ULAF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ULAF_ECOLI ## Database ID URL or Descriptions # AltName KDUI_ECOLI 5-keto-4-deoxyuronate isomerase # AltName KDUI_ECOLI DKI isomerase # BRENDA 5.3.1.17 2026 # BioGrid 4261944 13 # CATALYTIC ACTIVITY KDUI_ECOLI 5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D- glycero-2,5-hexodiulosonate. # COFACTOR KDUI_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 16152643, ECO 0000305}; Note=Binds 1 zinc ion per subunit. The bound metal seen in the crystal structure was tentatively identified as zinc, and its requirement for activity has not been shown. {ECO 0000269|PubMed 16152643, ECO 0000305}; # EcoGene EG13096 kduI # FUNCTION KDUI_ECOLI Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity). Plays a role in the catabolism of hexuronates under osmotic stress conditions, likely substituting for the regular hexuronate degrading enzyme UxaC whose expression is repressed in these conditions (PubMed 23437267). {ECO 0000250|UniProtKB Q05529, ECO 0000269|PubMed 23437267}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0008270 zinc ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008697 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IDA:EcoCyc. # GO_process GO:0019698 D-galacturonate catabolic process; IDA:EcoCyc. # GO_process GO:0042840 D-glucuronate catabolic process; IDA:EcoCyc. # GO_process GO:0045490 pectin catabolic process; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 2.60.120.500 -; 1. # Gene3D 2.60.120.520 -; 1. # HAMAP MF_00687 KduI # INDUCTION KDUI_ECOLI Its expression is up-regulated in the presence of galacturonate and glucuronate (PubMed 23437267). Is also down- regulated in E.coli of mice fed a casein-rich diet (PubMed 22427493). {ECO 0000269|PubMed 22427493, ECO 0000269|PubMed 23437267}. # IntAct Q46938 2 # InterPro IPR007045 KduI # InterPro IPR011051 RmlC_Cupin # InterPro IPR021120 KduI/IolB_isomerase # InterPro IPR027447 KduI_C # InterPro IPR027449 KduI_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00040 Pentose and glucuronate interconversions # Organism KDUI_ECOLI Escherichia coli (strain K12) # PATHWAY Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy- D-gluconate from pectin step 4/5. # PATRIC 32121104 VBIEscCol129921_2941 # PDB 1X8M X-ray; 2.60 A; A/B/C/D/E/F=2-278 # PDB 1XRU X-ray; 1.94 A; A/B=1-278 # PIR D65067 D65067 # PIRSF PIRSF006625 KduI # Pfam PF04962 KduI # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName KDUI_ECOLI 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase # RefSeq NP_417320 NC_000913.3 # RefSeq WP_000383237 NZ_LN832404.1 # SIMILARITY Belongs to the KduI family. {ECO 0000305}. # SUBUNIT KDUI_ECOLI Homohexamer. {ECO 0000269|PubMed 16152643, ECO 0000269|PubMed 9761873}. # SUPFAM SSF51182 SSF51182 # UniPathway UPA00545 UER00826 # eggNOG COG3717 LUCA # eggNOG ENOG4105D50 Bacteria BLAST swissprot:KDUI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:KDUI_ECOLI BioCyc ECOL316407:JW2811-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2811-MONOMER BioCyc EcoCyc:G7463-MONOMER http://biocyc.org/getid?id=EcoCyc:G7463-MONOMER BioCyc MetaCyc:G7463-MONOMER http://biocyc.org/getid?id=MetaCyc:G7463-MONOMER COG COG3717 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3717 DIP DIP-10069N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10069N DOI 10.1002/prot.20598 http://dx.doi.org/10.1002/prot.20598 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1107/S090744499701785X http://dx.doi.org/10.1107/S090744499701785X DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AEM.00244-12 http://dx.doi.org/10.1128/AEM.00244-12 DOI 10.1371/journal.pone.0056906 http://dx.doi.org/10.1371/journal.pone.0056906 EC_number EC:5.3.1.17 http://www.genome.jp/dbget-bin/www_bget?EC:5.3.1.17 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 ENZYME 5.3.1.17 http://enzyme.expasy.org/EC/5.3.1.17 EchoBASE EB2899 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2899 EcoGene EG13096 http://www.ecogene.org/geneInfo.php?eg_id=EG13096 EnsemblBacteria AAC75882 http://www.ensemblgenomes.org/id/AAC75882 EnsemblBacteria AAC75882 http://www.ensemblgenomes.org/id/AAC75882 EnsemblBacteria BAE76912 http://www.ensemblgenomes.org/id/BAE76912 EnsemblBacteria BAE76912 http://www.ensemblgenomes.org/id/BAE76912 EnsemblBacteria BAE76912 http://www.ensemblgenomes.org/id/BAE76912 EnsemblBacteria b2843 http://www.ensemblgenomes.org/id/b2843 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0008697 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008697 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0019698 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019698 GO_process GO:0042840 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042840 GO_process GO:0045490 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045490 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 2.60.120.500 http://www.cathdb.info/version/latest/superfamily/2.60.120.500 Gene3D 2.60.120.520 http://www.cathdb.info/version/latest/superfamily/2.60.120.520 GeneID 947319 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947319 HAMAP MF_00687 http://hamap.expasy.org/unirule/MF_00687 HOGENOM HOG000124379 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000124379&db=HOGENOM6 InParanoid Q46938 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46938 IntAct Q46938 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46938* IntEnz 5.3.1.17 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.3.1.17 InterPro IPR007045 http://www.ebi.ac.uk/interpro/entry/IPR007045 InterPro IPR011051 http://www.ebi.ac.uk/interpro/entry/IPR011051 InterPro IPR021120 http://www.ebi.ac.uk/interpro/entry/IPR021120 InterPro IPR027447 http://www.ebi.ac.uk/interpro/entry/IPR027447 InterPro IPR027449 http://www.ebi.ac.uk/interpro/entry/IPR027449 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2811 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2811 KEGG_Gene eco:b2843 http://www.genome.jp/dbget-bin/www_bget?eco:b2843 KEGG_Orthology KO:K01815 http://www.genome.jp/dbget-bin/www_bget?KO:K01815 KEGG_Pathway ko00040 http://www.genome.jp/kegg-bin/show_pathway?ko00040 KEGG_Reaction rn:R04383 http://www.genome.jp/dbget-bin/www_bget?rn:R04383 OMA IWAMAGE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IWAMAGE PDB 1X8M http://www.ebi.ac.uk/pdbe-srv/view/entry/1X8M PDB 1XRU http://www.ebi.ac.uk/pdbe-srv/view/entry/1XRU PDBsum 1X8M http://www.ebi.ac.uk/pdbsum/1X8M PDBsum 1XRU http://www.ebi.ac.uk/pdbsum/1XRU PSORT swissprot:KDUI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:KDUI_ECOLI PSORT-B swissprot:KDUI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:KDUI_ECOLI PSORT2 swissprot:KDUI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:KDUI_ECOLI Pfam PF04962 http://pfam.xfam.org/family/PF04962 Phobius swissprot:KDUI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:KDUI_ECOLI PhylomeDB Q46938 http://phylomedb.org/?seqid=Q46938 ProteinModelPortal Q46938 http://www.proteinmodelportal.org/query/uniprot/Q46938 PubMed 16152643 http://www.ncbi.nlm.nih.gov/pubmed/16152643 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22427493 http://www.ncbi.nlm.nih.gov/pubmed/22427493 PubMed 23437267 http://www.ncbi.nlm.nih.gov/pubmed/23437267 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9761873 http://www.ncbi.nlm.nih.gov/pubmed/9761873 RefSeq NP_417320 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417320 RefSeq WP_000383237 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000383237 SMR Q46938 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46938 STRING 511145.b2843 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2843&targetmode=cogs STRING COG3717 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3717&targetmode=cogs SUPFAM SSF51182 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51182 UniProtKB KDUI_ECOLI http://www.uniprot.org/uniprot/KDUI_ECOLI UniProtKB-AC Q46938 http://www.uniprot.org/uniprot/Q46938 charge swissprot:KDUI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:KDUI_ECOLI eggNOG COG3717 http://eggnogapi.embl.de/nog_data/html/tree/COG3717 eggNOG ENOG4105D50 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D50 epestfind swissprot:KDUI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:KDUI_ECOLI garnier swissprot:KDUI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:KDUI_ECOLI helixturnhelix swissprot:KDUI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:KDUI_ECOLI hmoment swissprot:KDUI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:KDUI_ECOLI iep swissprot:KDUI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:KDUI_ECOLI inforesidue swissprot:KDUI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:KDUI_ECOLI octanol swissprot:KDUI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:KDUI_ECOLI pepcoil swissprot:KDUI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:KDUI_ECOLI pepdigest swissprot:KDUI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:KDUI_ECOLI pepinfo swissprot:KDUI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:KDUI_ECOLI pepnet swissprot:KDUI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:KDUI_ECOLI pepstats swissprot:KDUI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:KDUI_ECOLI pepwheel swissprot:KDUI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:KDUI_ECOLI pepwindow swissprot:KDUI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:KDUI_ECOLI sigcleave swissprot:KDUI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:KDUI_ECOLI ## Database ID URL or Descriptions # BioGrid 4260295 15 # EcoGene EG13979 ydiT # FUNCTION YDIT_ECOLI Could be a 3Fe-4S cluster-containing protein. Probably participates in a redox process with YdiQ, YdiR and YdiS. # GO_function GO:0005506 iron ion binding; IEA:InterPro. # GO_function GO:0051536 iron-sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0055114 oxidation-reduction process; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # InterPro IPR012206 Fd_FixX # InterPro IPR017900 4Fe4S_Fe_S_CS # Organism YDIT_ECOLI Escherichia coli (strain K12) # PATRIC 32118706 VBIEscCol129921_1771 # PIR D64928 D64928 # PIRSF PIRSF036548 Fdx_FixX # PROSITE PS00198 4FE4S_FER_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDIT_ECOLI Ferredoxin-like protein YdiT # RefSeq NP_416215 NC_000913.3 # RefSeq WP_000081081 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial-type ferredoxin family. FixX subfamily. {ECO 0000305}. # eggNOG COG2440 LUCA # eggNOG ENOG41090P5 Bacteria BLAST swissprot:YDIT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDIT_ECOLI BioCyc ECOL316407:JW1690-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1690-MONOMER BioCyc EcoCyc:G6923-MONOMER http://biocyc.org/getid?id=EcoCyc:G6923-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3736 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3736 EcoGene EG13979 http://www.ecogene.org/geneInfo.php?eg_id=EG13979 EnsemblBacteria AAC74770 http://www.ensemblgenomes.org/id/AAC74770 EnsemblBacteria AAC74770 http://www.ensemblgenomes.org/id/AAC74770 EnsemblBacteria BAA15469 http://www.ensemblgenomes.org/id/BAA15469 EnsemblBacteria BAA15469 http://www.ensemblgenomes.org/id/BAA15469 EnsemblBacteria BAA15469 http://www.ensemblgenomes.org/id/BAA15469 EnsemblBacteria b1700 http://www.ensemblgenomes.org/id/b1700 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0051536 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051536 GO_process GO:0055114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 946214 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946214 HOGENOM HOG000018925 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000018925&db=HOGENOM6 InParanoid P77714 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77714 InterPro IPR012206 http://www.ebi.ac.uk/interpro/entry/IPR012206 InterPro IPR017900 http://www.ebi.ac.uk/interpro/entry/IPR017900 KEGG_Gene ecj:JW1690 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1690 KEGG_Gene eco:b1700 http://www.genome.jp/dbget-bin/www_bget?eco:b1700 OMA RFDSAGC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RFDSAGC PROSITE PS00198 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00198 PSORT swissprot:YDIT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDIT_ECOLI PSORT-B swissprot:YDIT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDIT_ECOLI PSORT2 swissprot:YDIT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDIT_ECOLI Phobius swissprot:YDIT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDIT_ECOLI PhylomeDB P77714 http://phylomedb.org/?seqid=P77714 ProteinModelPortal P77714 http://www.proteinmodelportal.org/query/uniprot/P77714 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416215 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416215 RefSeq WP_000081081 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000081081 STRING 511145.b1700 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1700&targetmode=cogs UniProtKB YDIT_ECOLI http://www.uniprot.org/uniprot/YDIT_ECOLI UniProtKB-AC P77714 http://www.uniprot.org/uniprot/P77714 charge swissprot:YDIT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDIT_ECOLI eggNOG COG2440 http://eggnogapi.embl.de/nog_data/html/tree/COG2440 eggNOG ENOG41090P5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41090P5 epestfind swissprot:YDIT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDIT_ECOLI garnier swissprot:YDIT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDIT_ECOLI helixturnhelix swissprot:YDIT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDIT_ECOLI hmoment swissprot:YDIT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDIT_ECOLI iep swissprot:YDIT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDIT_ECOLI inforesidue swissprot:YDIT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDIT_ECOLI octanol swissprot:YDIT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDIT_ECOLI pepcoil swissprot:YDIT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDIT_ECOLI pepdigest swissprot:YDIT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDIT_ECOLI pepinfo swissprot:YDIT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDIT_ECOLI pepnet swissprot:YDIT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDIT_ECOLI pepstats swissprot:YDIT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDIT_ECOLI pepwheel swissprot:YDIT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDIT_ECOLI pepwindow swissprot:YDIT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDIT_ECOLI sigcleave swissprot:YDIT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDIT_ECOLI ## Database ID URL or Descriptions # EcoGene EG14173 yffL # Organism YFFL_ECOLI Escherichia coli (strain K12) # PIR B65019 B65019 # Proteomes UP000000625 Chromosome # RecName YFFL_ECOLI Uncharacterized protein YffL # RefSeq NP_416938 NC_000913.3 # RefSeq WP_000458337 NZ_CP014272.1 BLAST swissprot:YFFL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFFL_ECOLI BioCyc EcoCyc:G7273-MONOMER http://biocyc.org/getid?id=EcoCyc:G7273-MONOMER DIP DIP-12026N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12026N DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3925 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3925 EcoGene EG14173 http://www.ecogene.org/geneInfo.php?eg_id=EG14173 EnsemblBacteria AAC75496 http://www.ensemblgenomes.org/id/AAC75496 EnsemblBacteria AAC75496 http://www.ensemblgenomes.org/id/AAC75496 EnsemblBacteria b2443 http://www.ensemblgenomes.org/id/b2443 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946922 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946922 IntAct P76543 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76543* KEGG_Gene eco:b2443 http://www.genome.jp/dbget-bin/www_bget?eco:b2443 PSORT swissprot:YFFL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFFL_ECOLI PSORT-B swissprot:YFFL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFFL_ECOLI PSORT2 swissprot:YFFL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFFL_ECOLI Phobius swissprot:YFFL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFFL_ECOLI ProteinModelPortal P76543 http://www.proteinmodelportal.org/query/uniprot/P76543 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416938 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416938 RefSeq WP_000458337 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000458337 SMR P76543 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76543 STRING 511145.b2443 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2443&targetmode=cogs UniProtKB YFFL_ECOLI http://www.uniprot.org/uniprot/YFFL_ECOLI UniProtKB-AC P76543 http://www.uniprot.org/uniprot/P76543 charge swissprot:YFFL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFFL_ECOLI epestfind swissprot:YFFL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFFL_ECOLI garnier swissprot:YFFL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFFL_ECOLI helixturnhelix swissprot:YFFL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFFL_ECOLI hmoment swissprot:YFFL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFFL_ECOLI iep swissprot:YFFL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFFL_ECOLI inforesidue swissprot:YFFL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFFL_ECOLI octanol swissprot:YFFL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFFL_ECOLI pepcoil swissprot:YFFL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFFL_ECOLI pepdigest swissprot:YFFL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFFL_ECOLI pepinfo swissprot:YFFL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFFL_ECOLI pepnet swissprot:YFFL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFFL_ECOLI pepstats swissprot:YFFL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFFL_ECOLI pepwheel swissprot:YFFL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFFL_ECOLI pepwindow swissprot:YFFL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFFL_ECOLI sigcleave swissprot:YFFL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFFL_ECOLI ## Database ID URL or Descriptions # BioGrid 4260790 10 # CAUTION Despite its homology to the anaerobic sulfatase- maturating enzymes, it is not involved in Cys-type sulfatase maturation in vivo. {ECO 0000305}. # COFACTOR YDEM_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000305}; Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. {ECO 0000305}; # COFACTOR YDEM_ECOLI Name=iron-sulfur cluster; Xref=ChEBI CHEBI 30408; Evidence={ECO 0000305}; Note=May bind at least one other iron-sulfur cluster. {ECO 0000305}; # EcoGene EG13795 ydeM # GO_function GO:0016491 oxidoreductase activity; IEA:InterPro. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0051604 protein maturation; ISS:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0051604 protein maturation # Gene3D 3.20.20.70 -; 1. # InterPro IPR007197 rSAM # InterPro IPR013785 Aldolase_TIM # InterPro IPR023867 Sulphatase_maturase_rSAM # InterPro IPR023885 4Fe4S-binding_SPASM_dom # Organism YDEM_ECOLI Escherichia coli (strain K12) # PATRIC 32118288 VBIEscCol129921_1564 # PIR D64903 D64903 # Pfam PF04055 Radical_SAM # Pfam PF13186 SPASM # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDEM_ECOLI Anaerobic sulfatase-maturating enzyme homolog YdeM # RefSeq NP_416014 NC_000913.3 # RefSeq WP_001301030 NZ_LN832404.1 # SIMILARITY Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family. {ECO 0000305}. # TIGRFAMs TIGR03942 sulfatase_rSAM # TIGRFAMs TIGR04085 rSAM_more_4Fe4S # eggNOG COG0641 LUCA # eggNOG ENOG4105C4X Bacteria BLAST swissprot:YDEM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDEM_ECOLI BioCyc ECOL316407:JW1492-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1492-MONOMER BioCyc EcoCyc:G6787-MONOMER http://biocyc.org/getid?id=EcoCyc:G6787-MONOMER COG COG0641 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0641 DOI 10.1016/j.febslet.2007.01.076 http://dx.doi.org/10.1016/j.febslet.2007.01.076 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3556 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3556 EcoGene EG13795 http://www.ecogene.org/geneInfo.php?eg_id=EG13795 EnsemblBacteria AAC74570 http://www.ensemblgenomes.org/id/AAC74570 EnsemblBacteria AAC74570 http://www.ensemblgenomes.org/id/AAC74570 EnsemblBacteria BAA15168 http://www.ensemblgenomes.org/id/BAA15168 EnsemblBacteria BAA15168 http://www.ensemblgenomes.org/id/BAA15168 EnsemblBacteria BAA15168 http://www.ensemblgenomes.org/id/BAA15168 EnsemblBacteria b1497 http://www.ensemblgenomes.org/id/b1497 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 945981 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945981 HOGENOM HOG000000300 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000000300&db=HOGENOM6 InParanoid P76134 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76134 IntAct P76134 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76134* InterPro IPR007197 http://www.ebi.ac.uk/interpro/entry/IPR007197 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR023867 http://www.ebi.ac.uk/interpro/entry/IPR023867 InterPro IPR023885 http://www.ebi.ac.uk/interpro/entry/IPR023885 KEGG_Gene ecj:JW1492 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1492 KEGG_Gene eco:b1497 http://www.genome.jp/dbget-bin/www_bget?eco:b1497 KEGG_Orthology KO:K06871 http://www.genome.jp/dbget-bin/www_bget?KO:K06871 OMA INIFDEW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=INIFDEW PSORT swissprot:YDEM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDEM_ECOLI PSORT-B swissprot:YDEM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDEM_ECOLI PSORT2 swissprot:YDEM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDEM_ECOLI Pfam PF04055 http://pfam.xfam.org/family/PF04055 Pfam PF13186 http://pfam.xfam.org/family/PF13186 Phobius swissprot:YDEM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDEM_ECOLI PhylomeDB P76134 http://phylomedb.org/?seqid=P76134 ProteinModelPortal P76134 http://www.proteinmodelportal.org/query/uniprot/P76134 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17303125 http://www.ncbi.nlm.nih.gov/pubmed/17303125 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416014 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416014 RefSeq WP_001301030 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001301030 SMR P76134 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76134 STRING 511145.b1497 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1497&targetmode=cogs STRING COG0641 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0641&targetmode=cogs TIGRFAMs TIGR03942 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03942 TIGRFAMs TIGR04085 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR04085 UniProtKB YDEM_ECOLI http://www.uniprot.org/uniprot/YDEM_ECOLI UniProtKB-AC P76134 http://www.uniprot.org/uniprot/P76134 charge swissprot:YDEM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDEM_ECOLI eggNOG COG0641 http://eggnogapi.embl.de/nog_data/html/tree/COG0641 eggNOG ENOG4105C4X http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C4X epestfind swissprot:YDEM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDEM_ECOLI garnier swissprot:YDEM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDEM_ECOLI helixturnhelix swissprot:YDEM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDEM_ECOLI hmoment swissprot:YDEM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDEM_ECOLI iep swissprot:YDEM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDEM_ECOLI inforesidue swissprot:YDEM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDEM_ECOLI octanol swissprot:YDEM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDEM_ECOLI pepcoil swissprot:YDEM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDEM_ECOLI pepdigest swissprot:YDEM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDEM_ECOLI pepinfo swissprot:YDEM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDEM_ECOLI pepnet swissprot:YDEM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDEM_ECOLI pepstats swissprot:YDEM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDEM_ECOLI pepwheel swissprot:YDEM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDEM_ECOLI pepwindow swissprot:YDEM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDEM_ECOLI sigcleave swissprot:YDEM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDEM_ECOLI ## Database ID URL or Descriptions # AltName HEXR_ECOLI Hex regulon repressor # BioGrid 4260935 12 # EcoGene EG12860 hexR # FUNCTION HEXR_ECOLI Represses the expression of the hex regulon (zwf, eda, glp and gap). {ECO 0000250}. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_function GO:0030246 carbohydrate binding; IEA:InterPro. # GO_process GO:0005975 carbohydrate metabolic process; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # IntAct P46118 2 # InterPro IPR000281 HTH_RpiR # InterPro IPR001347 SIS # InterPro IPR009057 Homeodomain-like # InterPro IPR011991 WHTH_DNA-bd_dom # Organism HEXR_ECOLI Escherichia coli (strain K12) # PATRIC 32119029 VBIEscCol129921_1932 # PIR E64947 E64947 # PROSITE PS51071 HTH_RPIR # PROSITE PS51464 SIS # Pfam PF01380 SIS # Pfam PF01418 HTH_6 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HEXR_ECOLI HTH-type transcriptional regulator HexR # RefSeq NP_416367 NC_000913.3 # RefSeq WP_001056706 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=M55005; Type=Frameshift; Positions=32, 63; Evidence={ECO 0000305}; # SIMILARITY Contains 1 HTH rpiR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00390}. # SIMILARITY Contains 1 SIS domain. {ECO:0000255|PROSITE- ProRule PRU00797}. # SUPFAM SSF46689 SSF46689 # eggNOG COG1737 LUCA # eggNOG ENOG4106KNT Bacteria BLAST swissprot:HEXR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HEXR_ECOLI BioCyc ECOL316407:JW1842-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1842-MONOMER BioCyc EcoCyc:EG12860-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12860-MONOMER DIP DIP-9891N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9891N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M55005 http://www.ebi.ac.uk/ena/data/view/M55005 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U27210 http://www.ebi.ac.uk/ena/data/view/U27210 EchoBASE EB2702 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2702 EcoGene EG12860 http://www.ecogene.org/geneInfo.php?eg_id=EG12860 EnsemblBacteria AAC74923 http://www.ensemblgenomes.org/id/AAC74923 EnsemblBacteria AAC74923 http://www.ensemblgenomes.org/id/AAC74923 EnsemblBacteria BAA15661 http://www.ensemblgenomes.org/id/BAA15661 EnsemblBacteria BAA15661 http://www.ensemblgenomes.org/id/BAA15661 EnsemblBacteria BAA15661 http://www.ensemblgenomes.org/id/BAA15661 EnsemblBacteria b1853 http://www.ensemblgenomes.org/id/b1853 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0030246 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030246 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 946373 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946373 HOGENOM HOG000027158 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000027158&db=HOGENOM6 InParanoid P46118 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P46118 IntAct P46118 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P46118* InterPro IPR000281 http://www.ebi.ac.uk/interpro/entry/IPR000281 InterPro IPR001347 http://www.ebi.ac.uk/interpro/entry/IPR001347 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW1842 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1842 KEGG_Gene eco:b1853 http://www.genome.jp/dbget-bin/www_bget?eco:b1853 OMA DRYSPMV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DRYSPMV PROSITE PS51071 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51071 PROSITE PS51464 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51464 PSORT swissprot:HEXR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HEXR_ECOLI PSORT-B swissprot:HEXR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HEXR_ECOLI PSORT2 swissprot:HEXR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HEXR_ECOLI Pfam PF01380 http://pfam.xfam.org/family/PF01380 Pfam PF01418 http://pfam.xfam.org/family/PF01418 Phobius swissprot:HEXR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HEXR_ECOLI PhylomeDB P46118 http://phylomedb.org/?seqid=P46118 ProteinModelPortal P46118 http://www.proteinmodelportal.org/query/uniprot/P46118 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1704005 http://www.ncbi.nlm.nih.gov/pubmed/1704005 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416367 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416367 RefSeq WP_001056706 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001056706 SMR P46118 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P46118 STRING 511145.b1853 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1853&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 UniProtKB HEXR_ECOLI http://www.uniprot.org/uniprot/HEXR_ECOLI UniProtKB-AC P46118 http://www.uniprot.org/uniprot/P46118 charge swissprot:HEXR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HEXR_ECOLI eggNOG COG1737 http://eggnogapi.embl.de/nog_data/html/tree/COG1737 eggNOG ENOG4106KNT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106KNT epestfind swissprot:HEXR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HEXR_ECOLI garnier swissprot:HEXR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HEXR_ECOLI helixturnhelix swissprot:HEXR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HEXR_ECOLI hmoment swissprot:HEXR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HEXR_ECOLI iep swissprot:HEXR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HEXR_ECOLI inforesidue swissprot:HEXR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HEXR_ECOLI octanol swissprot:HEXR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HEXR_ECOLI pepcoil swissprot:HEXR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HEXR_ECOLI pepdigest swissprot:HEXR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HEXR_ECOLI pepinfo swissprot:HEXR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HEXR_ECOLI pepnet swissprot:HEXR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HEXR_ECOLI pepstats swissprot:HEXR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HEXR_ECOLI pepwheel swissprot:HEXR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HEXR_ECOLI pepwindow swissprot:HEXR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HEXR_ECOLI sigcleave swissprot:HEXR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HEXR_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES PLAP_ECOLI Kinetic parameters KM=155 uM for putrescine {ECO 0000269|PubMed 21266585}; Vmax=9.3 nmol/min/mg enzyme {ECO 0000269|PubMed 21266585}; # BioGrid 4260417 152 # EcoGene EG11896 plaP # FUNCTION PLAP_ECOLI Putrescine importer. Required for induction of type 1 pili-driven surface motility. {ECO 0000269|PubMed 21266585}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0015179 L-amino acid transmembrane transporter activity; IBA:GO_Central. # GO_function GO:0015297 antiporter activity; IBA:GO_Central. # GO_function GO:0015489 putrescine transmembrane transporter activity; IMP:EcoCyc. # GO_function PLAP_ECOLI GO 0015295 solute proton symporter activity; IDA EcoCyc. # GO_process GO:0015847 putrescine transport; IMP:EcoCyc. # GO_process GO:0048870 cell motility; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0048870 cell motility # InterPro IPR002293 AA/rel_permease1 # Organism PLAP_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11785 PTHR11785 # PATRIC 32119363 VBIEscCol129921_2091 # PIR E64966 E64966 # PIRSF PIRSF006060 AA_transporter # Pfam PF13520 AA_permease_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PLAP_ECOLI Low-affinity putrescine importer PlaP # RefSeq NP_416518 NC_000913.3 # RefSeq WP_000019197 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA16420.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the amino acid-polyamine-organocation (APC) superfamily. {ECO 0000305}. # SUBCELLULAR LOCATION PLAP_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.3.1.14 the amino acid-polyamine-organocation (apc) family # eggNOG COG0531 LUCA # eggNOG ENOG4105CUB Bacteria BLAST swissprot:PLAP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PLAP_ECOLI BioCyc ECOL316407:JW5330-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5330-MONOMER BioCyc EcoCyc:YEEF-MONOMER http://biocyc.org/getid?id=EcoCyc:YEEF-MONOMER BioCyc MetaCyc:YEEF-MONOMER http://biocyc.org/getid?id=MetaCyc:YEEF-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M110.176032 http://dx.doi.org/10.1074/jbc.M110.176032 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00009 http://www.ebi.ac.uk/ena/data/view/U00009 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1842 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1842 EcoGene EG11896 http://www.ecogene.org/geneInfo.php?eg_id=EG11896 EnsemblBacteria AAC75075 http://www.ensemblgenomes.org/id/AAC75075 EnsemblBacteria AAC75075 http://www.ensemblgenomes.org/id/AAC75075 EnsemblBacteria BAA15842 http://www.ensemblgenomes.org/id/BAA15842 EnsemblBacteria BAA15842 http://www.ensemblgenomes.org/id/BAA15842 EnsemblBacteria BAA15842 http://www.ensemblgenomes.org/id/BAA15842 EnsemblBacteria b2014 http://www.ensemblgenomes.org/id/b2014 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015179 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015179 GO_function GO:0015295 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015295 GO_function GO:0015297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015297 GO_function GO:0015489 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015489 GO_process GO:0015847 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015847 GO_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 GeneID 946533 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946533 HOGENOM HOG000164060 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000164060&db=HOGENOM6 InParanoid P0AA47 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AA47 IntAct P0AA47 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AA47* InterPro IPR002293 http://www.ebi.ac.uk/interpro/entry/IPR002293 KEGG_Gene ecj:JW5330 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5330 KEGG_Gene eco:b2014 http://www.genome.jp/dbget-bin/www_bget?eco:b2014 OMA PAVGFMV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PAVGFMV PANTHER PTHR11785 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11785 PSORT swissprot:PLAP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PLAP_ECOLI PSORT-B swissprot:PLAP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PLAP_ECOLI PSORT2 swissprot:PLAP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PLAP_ECOLI Pfam PF13520 http://pfam.xfam.org/family/PF13520 Phobius swissprot:PLAP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PLAP_ECOLI PhylomeDB P0AA47 http://phylomedb.org/?seqid=P0AA47 ProteinModelPortal P0AA47 http://www.proteinmodelportal.org/query/uniprot/P0AA47 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21266585 http://www.ncbi.nlm.nih.gov/pubmed/21266585 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416518 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416518 RefSeq WP_000019197 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000019197 STRING 511145.b2014 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2014&targetmode=cogs TCDB 2.A.3.1.14 http://www.tcdb.org/search/result.php?tc=2.A.3.1.14 UniProtKB PLAP_ECOLI http://www.uniprot.org/uniprot/PLAP_ECOLI UniProtKB-AC P0AA47 http://www.uniprot.org/uniprot/P0AA47 charge swissprot:PLAP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PLAP_ECOLI eggNOG COG0531 http://eggnogapi.embl.de/nog_data/html/tree/COG0531 eggNOG ENOG4105CUB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CUB epestfind swissprot:PLAP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PLAP_ECOLI garnier swissprot:PLAP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PLAP_ECOLI helixturnhelix swissprot:PLAP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PLAP_ECOLI hmoment swissprot:PLAP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PLAP_ECOLI iep swissprot:PLAP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PLAP_ECOLI inforesidue swissprot:PLAP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PLAP_ECOLI octanol swissprot:PLAP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PLAP_ECOLI pepcoil swissprot:PLAP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PLAP_ECOLI pepdigest swissprot:PLAP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PLAP_ECOLI pepinfo swissprot:PLAP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PLAP_ECOLI pepnet swissprot:PLAP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PLAP_ECOLI pepstats swissprot:PLAP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PLAP_ECOLI pepwheel swissprot:PLAP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PLAP_ECOLI pepwindow swissprot:PLAP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PLAP_ECOLI sigcleave swissprot:PLAP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PLAP_ECOLI ## Database ID URL or Descriptions # AltName NORW_ECOLI Flavorubredoxin reductase # BioGrid 4259424 14 # CATALYTIC ACTIVITY NORW_ECOLI Reduced NO reductase rubredoxin + NAD(+) = oxidized NO reductase rubredoxin + NADH. # COFACTOR Name=FAD; Xref=ChEBI:CHEBI 57692; Evidence={ECO:0000305}; # EcoGene EG12450 norW # FUNCTION NORW_ECOLI One of at least two accessory proteins for anaerobic nitric oxide (NO) reductase. Reduces the rubredoxin moiety of NO reductase. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0015044 rubredoxin-NAD+ reductase activity; IDA:EcoCyc. # GO_function GO:0016731 oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor; IDA:EcoCyc. # GO_function GO:0050660 flavin adenine dinucleotide binding; IDA:EcoCyc. # GO_process GO:0046210 nitric oxide catabolic process; IMP:EcoCyc. # GO_process GO:0071732 cellular response to nitric oxide; IEP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.50.50.60 -; 2. # HAMAP MF_01313 NorW # INDUCTION NORW_ECOLI Submicromolar concentrations of NO induce anaerobic expression. Repressed by oxygen in the presence of NO. # InterPro IPR023753 FAD/NAD-binding_dom # InterPro IPR023961 NO_rdtase_NorW # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko05132 Salmonella infection # Organism NORW_ECOLI Escherichia coli (strain K12) # PATHWAY NORW_ECOLI Nitrogen metabolism; nitric oxide reduction. # PATRIC 32120820 VBIEscCol129921_2802 # PIR C65051 C65051 # Pfam PF07992 Pyr_redox_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NORW_ECOLI Nitric oxide reductase FlRd-NAD(+) reductase # RefSeq NP_417191 NC_000913.3 # RefSeq WP_000064752 NZ_LN832404.1 # SIMILARITY Belongs to the FAD-dependent oxidoreductase family. {ECO 0000305}. # SUBCELLULAR LOCATION NORW_ECOLI Cytoplasm. # SUPFAM SSF51905 SSF51905 # eggNOG COG1251 LUCA # eggNOG ENOG4107QZF Bacteria BLAST swissprot:NORW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NORW_ECOLI BioCyc ECOL316407:JW2681-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2681-MONOMER BioCyc EcoCyc:EG12450-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12450-MONOMER COG COG0446 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0446 DOI 10.1021/bi001844y http://dx.doi.org/10.1021/bi001844y DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M110471200 http://dx.doi.org/10.1074/jbc.M110471200 DOI 10.1074/jbc.M203886200 http://dx.doi.org/10.1074/jbc.M203886200 DOI 10.1074/jbc.M212462200 http://dx.doi.org/10.1074/jbc.M212462200 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.18.1.- http://www.genome.jp/dbget-bin/www_bget?EC:1.18.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D14422 http://www.ebi.ac.uk/ena/data/view/D14422 EMBL D28595 http://www.ebi.ac.uk/ena/data/view/D28595 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 ENZYME 1.18.1.- http://enzyme.expasy.org/EC/1.18.1.- EchoBASE EB2344 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2344 EcoGene EG12450 http://www.ecogene.org/geneInfo.php?eg_id=EG12450 EnsemblBacteria AAC75753 http://www.ensemblgenomes.org/id/AAC75753 EnsemblBacteria AAC75753 http://www.ensemblgenomes.org/id/AAC75753 EnsemblBacteria BAE76788 http://www.ensemblgenomes.org/id/BAE76788 EnsemblBacteria BAE76788 http://www.ensemblgenomes.org/id/BAE76788 EnsemblBacteria BAE76788 http://www.ensemblgenomes.org/id/BAE76788 EnsemblBacteria b2711 http://www.ensemblgenomes.org/id/b2711 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0015044 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015044 GO_function GO:0016731 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016731 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_process GO:0046210 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046210 GO_process GO:0071732 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071732 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 GeneID 947088 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947088 HAMAP MF_01313 http://hamap.expasy.org/unirule/MF_01313 HOGENOM HOG000009393 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009393&db=HOGENOM6 InParanoid P37596 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37596 IntEnz 1.18.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.18.1 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 InterPro IPR023961 http://www.ebi.ac.uk/interpro/entry/IPR023961 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2681 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2681 KEGG_Gene eco:b2711 http://www.genome.jp/dbget-bin/www_bget?eco:b2711 KEGG_Orthology KO:K12265 http://www.genome.jp/dbget-bin/www_bget?KO:K12265 KEGG_Pathway ko05132 http://www.genome.jp/kegg-bin/show_pathway?ko05132 OMA TWVSDID http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TWVSDID PSORT swissprot:NORW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NORW_ECOLI PSORT-B swissprot:NORW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NORW_ECOLI PSORT2 swissprot:NORW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NORW_ECOLI Pfam PF07992 http://pfam.xfam.org/family/PF07992 Phobius swissprot:NORW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NORW_ECOLI PhylomeDB P37596 http://phylomedb.org/?seqid=P37596 ProteinModelPortal P37596 http://www.proteinmodelportal.org/query/uniprot/P37596 PubMed 11123953 http://www.ncbi.nlm.nih.gov/pubmed/11123953 PubMed 11751865 http://www.ncbi.nlm.nih.gov/pubmed/11751865 PubMed 12101220 http://www.ncbi.nlm.nih.gov/pubmed/12101220 PubMed 12529359 http://www.ncbi.nlm.nih.gov/pubmed/12529359 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417191 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417191 RefSeq WP_000064752 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000064752 SMR P37596 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37596 STRING 511145.b2711 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2711&targetmode=cogs STRING COG0446 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0446&targetmode=cogs SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 UniProtKB NORW_ECOLI http://www.uniprot.org/uniprot/NORW_ECOLI UniProtKB-AC P37596 http://www.uniprot.org/uniprot/P37596 charge swissprot:NORW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NORW_ECOLI eggNOG COG1251 http://eggnogapi.embl.de/nog_data/html/tree/COG1251 eggNOG ENOG4107QZF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QZF epestfind swissprot:NORW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NORW_ECOLI garnier swissprot:NORW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NORW_ECOLI helixturnhelix swissprot:NORW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NORW_ECOLI hmoment swissprot:NORW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NORW_ECOLI iep swissprot:NORW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NORW_ECOLI inforesidue swissprot:NORW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NORW_ECOLI octanol swissprot:NORW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NORW_ECOLI pepcoil swissprot:NORW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NORW_ECOLI pepdigest swissprot:NORW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NORW_ECOLI pepinfo swissprot:NORW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NORW_ECOLI pepnet swissprot:NORW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NORW_ECOLI pepstats swissprot:NORW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NORW_ECOLI pepwheel swissprot:NORW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NORW_ECOLI pepwindow swissprot:NORW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NORW_ECOLI sigcleave swissprot:NORW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NORW_ECOLI ## Database ID URL or Descriptions # AltName YDDE_ECOLI ORFB # BioGrid 4262893 18 # EcoGene EG11825 yddE # GO_function GO:0016853 isomerase activity; IEA:UniProtKB-KW. # GO_process GO:0009058 biosynthetic process; IEA:InterPro. # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0009058 biosynthetic process # IntAct P37757 5 # InterPro IPR003719 Phenazine_PhzF # Organism YDDE_ECOLI Escherichia coli (strain K12) # PATRIC 32118220 VBIEscCol129921_1530 # PDB 1QY9 X-ray; 2.05 A; A/B/C/D=1-297 # PDB 1QYA X-ray; 2.00 A; A/B=2-297 # PDB 1SDJ X-ray; 2.30 A; A=1-297 # PIR C64899 C64899 # PIRSF PIRSF016184 PhzC_PhzF # Pfam PF02567 PhzC-PhzF # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDDE_ECOLI Uncharacterized isomerase YddE # RefSeq NP_415981 NC_000913.3 # RefSeq WP_000804385 NZ_LN832404.1 # SIMILARITY Belongs to the PhzF family. {ECO 0000305}. # SUBUNIT Homodimer and homotetramer. {ECO:0000269|PubMed 15103639}. # TIGRFAMs TIGR00654 PhzF_family # eggNOG COG0384 LUCA # eggNOG ENOG4105JAB Bacteria BLAST swissprot:YDDE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDDE_ECOLI BioCyc ECOL316407:JW1459-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1459-MONOMER BioCyc EcoCyc:EG11825-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11825-MONOMER COG COG0384 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0384 DOI 10.1002/prot.20025 http://dx.doi.org/10.1002/prot.20025 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.1.-.- http://www.genome.jp/dbget-bin/www_bget?EC:5.1.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X17110 http://www.ebi.ac.uk/ena/data/view/X17110 ENZYME 5.1.-.- http://enzyme.expasy.org/EC/5.1.-.- EchoBASE EB1772 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1772 EcoGene EG11825 http://www.ecogene.org/geneInfo.php?eg_id=EG11825 EnsemblBacteria AAC74546 http://www.ensemblgenomes.org/id/AAC74546 EnsemblBacteria AAC74546 http://www.ensemblgenomes.org/id/AAC74546 EnsemblBacteria BAA15101 http://www.ensemblgenomes.org/id/BAA15101 EnsemblBacteria BAA15101 http://www.ensemblgenomes.org/id/BAA15101 EnsemblBacteria BAA15101 http://www.ensemblgenomes.org/id/BAA15101 EnsemblBacteria b1464 http://www.ensemblgenomes.org/id/b1464 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GO_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 944782 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944782 HOGENOM HOG000251509 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000251509&db=HOGENOM6 InParanoid P37757 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37757 IntAct P37757 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37757* IntEnz 5.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.1 InterPro IPR003719 http://www.ebi.ac.uk/interpro/entry/IPR003719 KEGG_Gene ecj:JW1459 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1459 KEGG_Gene eco:b1464 http://www.genome.jp/dbget-bin/www_bget?eco:b1464 KEGG_Orthology KO:K06998 http://www.genome.jp/dbget-bin/www_bget?KO:K06998 OMA EQGHYVD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EQGHYVD PDB 1QY9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1QY9 PDB 1QYA http://www.ebi.ac.uk/pdbe-srv/view/entry/1QYA PDB 1SDJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1SDJ PDBsum 1QY9 http://www.ebi.ac.uk/pdbsum/1QY9 PDBsum 1QYA http://www.ebi.ac.uk/pdbsum/1QYA PDBsum 1SDJ http://www.ebi.ac.uk/pdbsum/1SDJ PSORT swissprot:YDDE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDDE_ECOLI PSORT-B swissprot:YDDE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDDE_ECOLI PSORT2 swissprot:YDDE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDDE_ECOLI Pfam PF02567 http://pfam.xfam.org/family/PF02567 Phobius swissprot:YDDE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDDE_ECOLI PhylomeDB P37757 http://phylomedb.org/?seqid=P37757 ProteinModelPortal P37757 http://www.proteinmodelportal.org/query/uniprot/P37757 PubMed 15103639 http://www.ncbi.nlm.nih.gov/pubmed/15103639 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2233673 http://www.ncbi.nlm.nih.gov/pubmed/2233673 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415981 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415981 RefSeq WP_000804385 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000804385 SMR P37757 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37757 STRING 511145.b1464 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1464&targetmode=cogs STRING COG0384 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0384&targetmode=cogs TIGRFAMs TIGR00654 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00654 UniProtKB YDDE_ECOLI http://www.uniprot.org/uniprot/YDDE_ECOLI UniProtKB-AC P37757 http://www.uniprot.org/uniprot/P37757 charge swissprot:YDDE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDDE_ECOLI eggNOG COG0384 http://eggnogapi.embl.de/nog_data/html/tree/COG0384 eggNOG ENOG4105JAB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105JAB epestfind swissprot:YDDE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDDE_ECOLI garnier swissprot:YDDE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDDE_ECOLI helixturnhelix swissprot:YDDE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDDE_ECOLI hmoment swissprot:YDDE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDDE_ECOLI iep swissprot:YDDE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDDE_ECOLI inforesidue swissprot:YDDE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDDE_ECOLI octanol swissprot:YDDE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDDE_ECOLI pepcoil swissprot:YDDE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDDE_ECOLI pepdigest swissprot:YDDE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDDE_ECOLI pepinfo swissprot:YDDE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDDE_ECOLI pepnet swissprot:YDDE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDDE_ECOLI pepstats swissprot:YDDE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDDE_ECOLI pepwheel swissprot:YDDE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDDE_ECOLI pepwindow swissprot:YDDE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDDE_ECOLI sigcleave swissprot:YDDE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDDE_ECOLI ## Database ID URL or Descriptions # BRENDA 2.7.13 2026 # BioGrid 4263084 3 # CATALYTIC ACTIVITY BASS_ECOLI ATP + protein L-histidine = ADP + protein N- phospho-L-histidine. # EcoGene EG11614 basS # FUNCTION BASS_ECOLI Member of the two-component regulatory system BasS/BasR Autophosphorylates and activates BasR by phosphorylation. {ECO 0000269|PubMed 15522865}. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0000155 phosphorelay sensor kinase activity; IMP:EcoCyc. # GO_function GO:0004673 protein histidine kinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IDA:EcoCyc. # GO_function GO:0016772 transferase activity, transferring phosphorus-containing groups; IDA:EcoCyc. # GO_process GO:0000160 phosphorelay signal transduction system; IDA:EcoCyc. # GO_process GO:0010041 response to iron(III) ion; IGI:EcoCyc. # GO_process GO:0018106 peptidyl-histidine phosphorylation; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005622 intracellular # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # Gene3D 1.10.287.130 -; 1. # Gene3D 3.30.565.10 -; 1. # INDUCTION The eptA-basRS operon is positively autoregulated by BasR under high iron or aluminum concentration conditions. {ECO 0000250}. # IntAct P30844 4 # InterPro IPR003594 HATPase_C # InterPro IPR003660 HAMP_dom # InterPro IPR003661 HisK_dim/P # InterPro IPR004358 Sig_transdc_His_kin-like_C # InterPro IPR005467 His_kinase_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01001 Protein kinases # KEGG_Brite ko02022 M00451 BasS-BasR (antimicrobial peptide resistance) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # Organism BASS_ECOLI Escherichia coli (strain K12) # PATRIC 32123789 VBIEscCol129921_4243 # PIR JX0285 JX0285 # PRINTS PR00344 BCTRLSENSOR # PROSITE PS50109 HIS_KIN # PROSITE PS50885 HAMP # PTM BASS_ECOLI Autophosphorylated. # Pfam PF00512 HisKA # Pfam PF00672 HAMP # Pfam PF02518 HATPase_c # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BASS_ECOLI Sensor protein BasS # RefSeq NP_418536 NC_000913.3 # RefSeq WP_001300761 NZ_LN832404.1 # SIMILARITY Contains 1 HAMP domain. {ECO:0000255|PROSITE- ProRule PRU00102}. # SIMILARITY Contains 1 histidine kinase domain. {ECO:0000255|PROSITE-ProRule PRU00107}. # SMART SM00304 HAMP # SMART SM00387 HATPase_c # SMART SM00388 HisKA # SUBCELLULAR LOCATION BASS_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF47384 SSF47384 # SUPFAM SSF55874 SSF55874 # eggNOG ENOG4105ECM Bacteria # eggNOG ENOG410XPUQ LUCA BLAST swissprot:BASS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BASS_ECOLI BioCyc ECOL316407:JW4073-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4073-MONOMER BioCyc EcoCyc:BASS-MONOMER http://biocyc.org/getid?id=EcoCyc:BASS-MONOMER COG COG0642 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0642 DIP DIP-9202N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9202N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M410104200 http://dx.doi.org/10.1074/jbc.M410104200 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.13.3 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.13.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D14055 http://www.ebi.ac.uk/ena/data/view/D14055 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 2.7.13.3 http://enzyme.expasy.org/EC/2.7.13.3 EchoBASE EB1571 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1571 EcoGene EG11614 http://www.ecogene.org/geneInfo.php?eg_id=EG11614 EnsemblBacteria AAC77073 http://www.ensemblgenomes.org/id/AAC77073 EnsemblBacteria AAC77073 http://www.ensemblgenomes.org/id/AAC77073 EnsemblBacteria BAE78114 http://www.ensemblgenomes.org/id/BAE78114 EnsemblBacteria BAE78114 http://www.ensemblgenomes.org/id/BAE78114 EnsemblBacteria BAE78114 http://www.ensemblgenomes.org/id/BAE78114 EnsemblBacteria b4112 http://www.ensemblgenomes.org/id/b4112 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0000155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000155 GO_function GO:0004673 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004673 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016772 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016772 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0010041 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010041 GO_process GO:0018106 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018106 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.10.287.130 http://www.cathdb.info/version/latest/superfamily/1.10.287.130 Gene3D 3.30.565.10 http://www.cathdb.info/version/latest/superfamily/3.30.565.10 GeneID 948632 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948632 HOGENOM HOG000127051 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000127051&db=HOGENOM6 InParanoid P30844 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30844 IntAct P30844 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P30844* IntEnz 2.7.13.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.13.3 InterPro IPR003594 http://www.ebi.ac.uk/interpro/entry/IPR003594 InterPro IPR003660 http://www.ebi.ac.uk/interpro/entry/IPR003660 InterPro IPR003661 http://www.ebi.ac.uk/interpro/entry/IPR003661 InterPro IPR004358 http://www.ebi.ac.uk/interpro/entry/IPR004358 InterPro IPR005467 http://www.ebi.ac.uk/interpro/entry/IPR005467 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01001 http://www.genome.jp/dbget-bin/www_bget?ko01001 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW4073 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4073 KEGG_Gene eco:b4112 http://www.genome.jp/dbget-bin/www_bget?eco:b4112 KEGG_Orthology KO:K07643 http://www.genome.jp/dbget-bin/www_bget?KO:K07643 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 MINT MINT-1257146 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1257146 OMA ELISIFW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ELISIFW PRINTS PR00344 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00344 PROSITE PS50109 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50109 PROSITE PS50885 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50885 PSORT swissprot:BASS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BASS_ECOLI PSORT-B swissprot:BASS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BASS_ECOLI PSORT2 swissprot:BASS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BASS_ECOLI Pfam PF00512 http://pfam.xfam.org/family/PF00512 Pfam PF00672 http://pfam.xfam.org/family/PF00672 Pfam PF02518 http://pfam.xfam.org/family/PF02518 Phobius swissprot:BASS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BASS_ECOLI PhylomeDB P30844 http://phylomedb.org/?seqid=P30844 ProteinModelPortal P30844 http://www.proteinmodelportal.org/query/uniprot/P30844 PubMed 15522865 http://www.ncbi.nlm.nih.gov/pubmed/15522865 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8282725 http://www.ncbi.nlm.nih.gov/pubmed/8282725 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418536 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418536 RefSeq WP_001300761 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300761 SMART SM00304 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00304 SMART SM00387 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00387 SMART SM00388 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00388 SMR P30844 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P30844 STRING 511145.b4112 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4112&targetmode=cogs STRING COG0642 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0642&targetmode=cogs SUPFAM SSF47384 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47384 SUPFAM SSF55874 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55874 UniProtKB BASS_ECOLI http://www.uniprot.org/uniprot/BASS_ECOLI UniProtKB-AC P30844 http://www.uniprot.org/uniprot/P30844 charge swissprot:BASS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BASS_ECOLI eggNOG ENOG4105ECM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ECM eggNOG ENOG410XPUQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPUQ epestfind swissprot:BASS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BASS_ECOLI garnier swissprot:BASS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BASS_ECOLI helixturnhelix swissprot:BASS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BASS_ECOLI hmoment swissprot:BASS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BASS_ECOLI iep swissprot:BASS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BASS_ECOLI inforesidue swissprot:BASS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BASS_ECOLI octanol swissprot:BASS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BASS_ECOLI pepcoil swissprot:BASS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BASS_ECOLI pepdigest swissprot:BASS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BASS_ECOLI pepinfo swissprot:BASS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BASS_ECOLI pepnet swissprot:BASS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BASS_ECOLI pepstats swissprot:BASS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BASS_ECOLI pepwheel swissprot:BASS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BASS_ECOLI pepwindow swissprot:BASS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BASS_ECOLI sigcleave swissprot:BASS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BASS_ECOLI ## Database ID URL or Descriptions # BioGrid 4259186 204 # CDD cd01948 EAL # EcoGene EG11145 yfeA # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GOslim_component GO:0005886 plasma membrane # Gene3D 3.20.20.450 -; 1. # INDUCTION Expressed during exponential and post-exponential growth at both 28 and 37 degrees Celsius. Repressed by RpoS. {ECO:0000269|PubMed 19332833}. # InterPro IPR000160 GGDEF_dom # InterPro IPR001633 EAL_dom # InterPro IPR007895 MASE1 # InterPro IPR029787 Nucleotide_cyclase # Organism YFEA_ECOLI Escherichia coli (strain K12) # PATRIC 32120167 VBIEscCol129921_2492 # PIR H65013 H65013 # PIR S11411 S11411 # PROSITE PS50883 EAL # PROSITE PS50887 GGDEF # Pfam PF00563 EAL # Pfam PF05231 MASE1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFEA_ECOLI Uncharacterized protein YfeA # RefSeq NP_416896 NC_000913.3 # RefSeq WP_000497400 NZ_LN832404.1 # SEQUENCE CAUTION YFEA_ECOLI Sequence=AAA65719.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=AAA65719.1; Type=Frameshift; Positions=112; Evidence={ECO 0000305}; Sequence=CAA45395.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=CAA45395.1; Type=Frameshift; Positions=112; Evidence={ECO 0000305}; # SIMILARITY Contains 1 EAL domain. {ECO:0000255|PROSITE- ProRule PRU00074}. # SIMILARITY Contains 1 GGDEF domain. {ECO:0000255|PROSITE- ProRule PRU00095}. # SMART SM00052 EAL # SMART SM00267 GGDEF # SUPFAM SSF141868 SSF141868 # SUPFAM SSF55073 SSF55073 # eggNOG ENOG4108KMM Bacteria # eggNOG ENOG41100B0 LUCA BLAST swissprot:YFEA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFEA_ECOLI BioCyc ECOL316407:JW5391-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5391-MONOMER BioCyc EcoCyc:EG11145-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11145-MONOMER DIP DIP-12011N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12011N DOI 10.1016/0022-2836(90)90339-N http://dx.doi.org/10.1016/0022-2836(90)90339-N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1099/mic.0.024257-0 http://dx.doi.org/10.1099/mic.0.024257-0 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M13687 http://www.ebi.ac.uk/ena/data/view/M13687 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X63976 http://www.ebi.ac.uk/ena/data/view/X63976 EchoBASE EB1135 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1135 EcoGene EG11145 http://www.ecogene.org/geneInfo.php?eg_id=EG11145 EnsemblBacteria AAC75454 http://www.ensemblgenomes.org/id/AAC75454 EnsemblBacteria AAC75454 http://www.ensemblgenomes.org/id/AAC75454 EnsemblBacteria BAA16267 http://www.ensemblgenomes.org/id/BAA16267 EnsemblBacteria BAA16267 http://www.ensemblgenomes.org/id/BAA16267 EnsemblBacteria BAA16267 http://www.ensemblgenomes.org/id/BAA16267 EnsemblBacteria b2395 http://www.ensemblgenomes.org/id/b2395 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 Gene3D 3.20.20.450 http://www.cathdb.info/version/latest/superfamily/3.20.20.450 GeneID 946864 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946864 HOGENOM HOG000122953 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122953&db=HOGENOM6 InParanoid P23842 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23842 IntAct P23842 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P23842* InterPro IPR000160 http://www.ebi.ac.uk/interpro/entry/IPR000160 InterPro IPR001633 http://www.ebi.ac.uk/interpro/entry/IPR001633 InterPro IPR007895 http://www.ebi.ac.uk/interpro/entry/IPR007895 InterPro IPR029787 http://www.ebi.ac.uk/interpro/entry/IPR029787 KEGG_Gene ecj:JW5391 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5391 KEGG_Gene eco:b2395 http://www.genome.jp/dbget-bin/www_bget?eco:b2395 MINT MINT-1223642 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1223642 OMA SVRFDMQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SVRFDMQ PROSITE PS50883 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50883 PROSITE PS50887 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50887 PSORT swissprot:YFEA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFEA_ECOLI PSORT-B swissprot:YFEA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFEA_ECOLI PSORT2 swissprot:YFEA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFEA_ECOLI Pfam PF00563 http://pfam.xfam.org/family/PF00563 Pfam PF05231 http://pfam.xfam.org/family/PF05231 Phobius swissprot:YFEA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFEA_ECOLI PhylomeDB P23842 http://phylomedb.org/?seqid=P23842 ProteinModelPortal P23842 http://www.proteinmodelportal.org/query/uniprot/P23842 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19332833 http://www.ncbi.nlm.nih.gov/pubmed/19332833 PubMed 2201776 http://www.ncbi.nlm.nih.gov/pubmed/2201776 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416896 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416896 RefSeq WP_000497400 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000497400 SMART SM00052 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00052 SMART SM00267 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00267 SMR P23842 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P23842 STRING 511145.b2395 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2395&targetmode=cogs SUPFAM SSF141868 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF141868 SUPFAM SSF55073 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55073 UniProtKB YFEA_ECOLI http://www.uniprot.org/uniprot/YFEA_ECOLI UniProtKB-AC P23842 http://www.uniprot.org/uniprot/P23842 charge swissprot:YFEA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFEA_ECOLI eggNOG ENOG4108KMM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108KMM eggNOG ENOG41100B0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41100B0 epestfind swissprot:YFEA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFEA_ECOLI garnier swissprot:YFEA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFEA_ECOLI helixturnhelix swissprot:YFEA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFEA_ECOLI hmoment swissprot:YFEA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFEA_ECOLI iep swissprot:YFEA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFEA_ECOLI inforesidue swissprot:YFEA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFEA_ECOLI octanol swissprot:YFEA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFEA_ECOLI pepcoil swissprot:YFEA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFEA_ECOLI pepdigest swissprot:YFEA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFEA_ECOLI pepinfo swissprot:YFEA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFEA_ECOLI pepnet swissprot:YFEA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFEA_ECOLI pepstats swissprot:YFEA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFEA_ECOLI pepwheel swissprot:YFEA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFEA_ECOLI pepwindow swissprot:YFEA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFEA_ECOLI sigcleave swissprot:YFEA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFEA_ECOLI ## Database ID URL or Descriptions # BRENDA 2.4.1.289 2026 # CAUTION WBBL_ECOLI PubMed 9097040, PubMed 9278503 and PubMed 16738553 sequences differ from that shown due to the presence of an IS5I insertion element between codons 148 and 149. {ECO 0000305}. # CAZy GT2 Glycosyltransferase Family 2 # EcoGene EG11986 wbbL # FUNCTION WBBL_ECOLI Rhamnosyltransferase involved in lipopolysaccharide biosynthesis. {ECO 0000269|PubMed 7517391}. # GO_function GO:0016757 transferase activity, transferring glycosyl groups; IBA:GO_Central. # GO_function GO:0016758 transferase activity, transferring hexosyl groups; IGI:UniProtKB. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IGI:UniProtKB. # GO_process GO:0045226 extracellular polysaccharide biosynthetic process; IGI:UniProtKB. # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.90.550.10 -; 1. # InterPro IPR029044 Nucleotide-diphossugar_trans # Organism WBBL_ECOLI Escherichia coli (strain K12) # PATHWAY WBBL_ECOLI Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. # PIR I76769 I76769 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName WBBL_ECOLI Rhamnosyltransferase WbbL # SIMILARITY Belongs to the glycosyltransferase 2 family. {ECO 0000305}. # SUPFAM SSF53448 SSF53448; 2 BLAST swissprot:WBBL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:WBBL_ECOLI BioCyc EcoCyc:EG11986-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11986-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1099/13500872-140-1-49 http://dx.doi.org/10.1099/13500872-140-1-49 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.4.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.4.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19537 http://www.ebi.ac.uk/ena/data/view/L19537 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U03041 http://www.ebi.ac.uk/ena/data/view/U03041 ENZYME 2.4.1.- http://enzyme.expasy.org/EC/2.4.1.- EchoBASE EB1929 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1929 EcoGene EG11986 http://www.ecogene.org/geneInfo.php?eg_id=EG11986 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GO_function GO:0016758 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016758 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GO_process GO:0045226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045226 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.90.550.10 http://www.cathdb.info/version/latest/superfamily/3.90.550.10 HOGENOM HOG000224390 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000224390&db=HOGENOM6 InParanoid P36667 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P36667 IntAct P36667 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P36667* IntEnz 2.4.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.1 InterPro IPR029044 http://www.ebi.ac.uk/interpro/entry/IPR029044 PSORT swissprot:WBBL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:WBBL_ECOLI PSORT-B swissprot:WBBL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:WBBL_ECOLI PSORT2 swissprot:WBBL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:WBBL_ECOLI Phobius swissprot:WBBL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:WBBL_ECOLI PhylomeDB P36667 http://phylomedb.org/?seqid=P36667 ProteinModelPortal P36667 http://www.proteinmodelportal.org/query/uniprot/P36667 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7512872 http://www.ncbi.nlm.nih.gov/pubmed/7512872 PubMed 7517390 http://www.ncbi.nlm.nih.gov/pubmed/7517390 PubMed 7517391 http://www.ncbi.nlm.nih.gov/pubmed/7517391 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SUPFAM SSF53448 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53448 UniProtKB WBBL_ECOLI http://www.uniprot.org/uniprot/WBBL_ECOLI UniProtKB-AC P36667 http://www.uniprot.org/uniprot/P36667 charge swissprot:WBBL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:WBBL_ECOLI epestfind swissprot:WBBL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:WBBL_ECOLI garnier swissprot:WBBL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:WBBL_ECOLI helixturnhelix swissprot:WBBL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:WBBL_ECOLI hmoment swissprot:WBBL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:WBBL_ECOLI iep swissprot:WBBL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:WBBL_ECOLI inforesidue swissprot:WBBL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:WBBL_ECOLI octanol swissprot:WBBL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:WBBL_ECOLI pepcoil swissprot:WBBL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:WBBL_ECOLI pepdigest swissprot:WBBL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:WBBL_ECOLI pepinfo swissprot:WBBL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:WBBL_ECOLI pepnet swissprot:WBBL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:WBBL_ECOLI pepstats swissprot:WBBL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:WBBL_ECOLI pepwheel swissprot:WBBL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:WBBL_ECOLI pepwindow swissprot:WBBL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:WBBL_ECOLI sigcleave swissprot:WBBL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:WBBL_ECOLI ## Database ID URL or Descriptions # AltName HDA_ECOLI DnaA paralog # BioGrid 4261436 149 # DISRUPTION PHENOTYPE HDA_ECOLI Essential in strain C600. Disruption in MG1655 confers cold-sensitivity with asynchronously replicating DNA, which is quickly suppressed. Increased levels of plasmid IncP-alpha RK2 in strain BL21-DE3, increased plasmid replication in vitro. {ECO 0000269|PubMed 11483528, ECO 0000269|PubMed 12618445, ECO 0000269|PubMed 22716942}. # EcoGene EG14201 hda # FUNCTION HDA_ECOLI Mediates the interactions of DNA replication initiator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinitiation, a process called regulatory inhibition of DnaA or RIDA. ADP-binding activates Hda to hydrolyze DnaA-ATP; Hda monomers bind to ADP with about 200-fold greater affinity than for ATP. RIDA function can be genetically separated from viability, suggesting this protein has another function as well. # FUNCTION HDA_ECOLI Suppresses the toxic effect of overexpressing a TrfA N- terminal 163 residue fragment. Inhibits inner membrane-associated plasmid IncP-alpha RK2 replication probably by interacting with plasmid-encoded TrfA. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016020 membrane; IDA:EcoCyc. # GO_function GO:0000166 nucleotide binding; IEA:UniProtKB-KW. # GO_function GO:0043565 sequence-specific DNA binding; IBA:GO_Central. # GO_process GO:0006260 DNA replication; IEA:UniProtKB-HAMAP. # GO_process GO:0032297 negative regulation of DNA-dependent DNA replication initiation; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.300 -; 1. # HAMAP MF_01158 Hda # INTERACTION HDA_ECOLI Self; NbExp=2; IntAct=EBI-545453, EBI-545453; P06134 ada; NbExp=3; IntAct=EBI-545453, EBI-1119501; P03004 dnaA; NbExp=2; IntAct=EBI-545453, EBI-548951; P0A988 dnaN; NbExp=8; IntAct=EBI-545453, EBI-542385; # IntAct P69931 14 # InterPro IPR013317 DnaA # InterPro IPR017788 Hda # InterPro IPR020591 Chromosome_initiator_DnaA-like # InterPro IPR022864 Hda_Enterobact # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko03032 DNA replication proteins # MISCELLANEOUS HDA_ECOLI Starts with a CTG codon. # MISCELLANEOUS HDA_ECOLI There are about 50 homodimers per cell in strains C600 and K12 / MG1655. # Organism HDA_ECOLI Escherichia coli (strain K12) # PATRIC 32120379 VBIEscCol129921_2592 # PIR G65025 G65025 # PRINTS PR00051 DNAA # Pfam PF00308 Bac_DnaA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HDA_ECOLI DnaA regulatory inactivator Hda # RefSeq NP_416991 NC_000913.3 # SIMILARITY Belongs to the DnaA family. HdA subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION HDA_ECOLI Cell inner membrane {ECO 0000269|PubMed 12618445}. Note=More protein is found in the inner than outer membrane fractions. # SUBUNIT HDA_ECOLI The active form seems to be an ADP-bound monomer; apo-Hda forms homo-multimers that do not hydrolzye DnaA-bound ATP. Forms the RIDA complex (regulatory inactivation of DnaA) of ATP-DnaA, ADP-Hda and the DNA-loaded beta sliding clamp (dnaN). Interacts with plasmid IncP-alpha RK2-encoded protein TrfA in strain B / BL21-DE3. {ECO 0000269|PubMed 12618445, ECO 0000269|PubMed 15150238, ECO 0000269|PubMed 15611053, ECO 0000269|PubMed 18977760}. # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR03420 DnaA_homol_Hda # eggNOG COG0593 LUCA # eggNOG ENOG4108KZ1 Bacteria BLAST swissprot:HDA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HDA_ECOLI BioCyc ECOL316407:JW5397-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5397-MONOMER BioCyc EcoCyc:G7313-MONOMER http://biocyc.org/getid?id=EcoCyc:G7313-MONOMER COG COG0593 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0593 DIP DIP-48006N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48006N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M412060200 http://dx.doi.org/10.1074/jbc.M412060200 DOI 10.1074/jbc.M803158200 http://dx.doi.org/10.1074/jbc.M803158200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/emboj/20.15.4253 http://dx.doi.org/10.1093/emboj/20.15.4253 DOI 10.1111/j.1365-2958.2012.08129.x http://dx.doi.org/10.1111/j.1365-2958.2012.08129.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.185.10.3244-3248.2003 http://dx.doi.org/10.1128/JB.185.10.3244-3248.2003 DOI 10.1128/JB.185.6.1817-1824.2003 http://dx.doi.org/10.1128/JB.185.6.1817-1824.2003 DOI 10.1128/JB.186.11.3508-3515.2004 http://dx.doi.org/10.1128/JB.186.11.3508-3515.2004 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3953 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3953 EcoGene EG14201 http://www.ecogene.org/geneInfo.php?eg_id=EG14201 EnsemblBacteria AAC75549 http://www.ensemblgenomes.org/id/AAC75549 EnsemblBacteria AAC75549 http://www.ensemblgenomes.org/id/AAC75549 EnsemblBacteria BAA16384 http://www.ensemblgenomes.org/id/BAA16384 EnsemblBacteria BAA16384 http://www.ensemblgenomes.org/id/BAA16384 EnsemblBacteria BAA16384 http://www.ensemblgenomes.org/id/BAA16384 EnsemblBacteria b2496 http://www.ensemblgenomes.org/id/b2496 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0000166 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000166 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260 GO_process GO:0032297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032297 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 946977 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946977 HAMAP MF_01158 http://hamap.expasy.org/unirule/MF_01158 HOGENOM HOG000256538 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000256538&db=HOGENOM6 InParanoid P69931 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P69931 IntAct P69931 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69931* InterPro IPR013317 http://www.ebi.ac.uk/interpro/entry/IPR013317 InterPro IPR017788 http://www.ebi.ac.uk/interpro/entry/IPR017788 InterPro IPR020591 http://www.ebi.ac.uk/interpro/entry/IPR020591 InterPro IPR022864 http://www.ebi.ac.uk/interpro/entry/IPR022864 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko03032 http://www.genome.jp/dbget-bin/www_bget?ko03032 KEGG_Gene ecj:JW5397 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5397 KEGG_Gene eco:b2496 http://www.genome.jp/dbget-bin/www_bget?eco:b2496 KEGG_Orthology KO:K10763 http://www.genome.jp/dbget-bin/www_bget?KO:K10763 PRINTS PR00051 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00051 PSORT swissprot:HDA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HDA_ECOLI PSORT-B swissprot:HDA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HDA_ECOLI PSORT2 swissprot:HDA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HDA_ECOLI Pfam PF00308 http://pfam.xfam.org/family/PF00308 Phobius swissprot:HDA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HDA_ECOLI PhylomeDB P69931 http://phylomedb.org/?seqid=P69931 ProteinModelPortal P69931 http://www.proteinmodelportal.org/query/uniprot/P69931 PubMed 11483528 http://www.ncbi.nlm.nih.gov/pubmed/11483528 PubMed 12618445 http://www.ncbi.nlm.nih.gov/pubmed/12618445 PubMed 12730188 http://www.ncbi.nlm.nih.gov/pubmed/12730188 PubMed 15150238 http://www.ncbi.nlm.nih.gov/pubmed/15150238 PubMed 15611053 http://www.ncbi.nlm.nih.gov/pubmed/15611053 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18977760 http://www.ncbi.nlm.nih.gov/pubmed/18977760 PubMed 22716942 http://www.ncbi.nlm.nih.gov/pubmed/22716942 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416991 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416991 SMR P69931 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69931 STRING 511145.b2496 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2496&targetmode=cogs STRING COG0593 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0593&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR03420 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03420 UniProtKB HDA_ECOLI http://www.uniprot.org/uniprot/HDA_ECOLI UniProtKB-AC P69931 http://www.uniprot.org/uniprot/P69931 charge swissprot:HDA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HDA_ECOLI eggNOG COG0593 http://eggnogapi.embl.de/nog_data/html/tree/COG0593 eggNOG ENOG4108KZ1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108KZ1 epestfind swissprot:HDA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HDA_ECOLI garnier swissprot:HDA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HDA_ECOLI helixturnhelix swissprot:HDA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HDA_ECOLI hmoment swissprot:HDA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HDA_ECOLI iep swissprot:HDA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HDA_ECOLI inforesidue swissprot:HDA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HDA_ECOLI octanol swissprot:HDA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HDA_ECOLI pepcoil swissprot:HDA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HDA_ECOLI pepdigest swissprot:HDA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HDA_ECOLI pepinfo swissprot:HDA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HDA_ECOLI pepnet swissprot:HDA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HDA_ECOLI pepstats swissprot:HDA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HDA_ECOLI pepwheel swissprot:HDA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HDA_ECOLI pepwindow swissprot:HDA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HDA_ECOLI sigcleave swissprot:HDA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HDA_ECOLI ## Database ID URL or Descriptions # AltName LPXD_ECOLI Protein FirA # AltName LPXD_ECOLI Rifampicin resistance protein # AltName LPXD_ECOLI UDP-3-O-(3-hydroxytetradecanoyl)glucosamine N-acyltransferase # BIOPHYSICOCHEMICAL PROPERTIES LPXD_ECOLI Kinetic parameters KM=2.5 uM for UDP-3-O-((3R)-hydroxytetradecanoyl)-alpha-D- glucosamine {ECO 0000269|PubMed 18422345}; KM=3.2 uM for (3R)-3-hydroxytetradecanoyl-ACP {ECO 0000269|PubMed 18422345}; Note=kcat is 23 sec(-1).; # BRENDA 2.3.1.191 2026 # BioGrid 4259589 431 # CATALYTIC ACTIVITY LPXD_ECOLI (3R)-3-hydroxytetradecanoyl-[acyl-carrier- protein] + UDP-3-O-((3R)-hydroxytetradecanoyl)-alpha-D-glucosamine = UDP-2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosamine + a holo-[acyl-carrier-protein]. {ECO 0000269|PubMed 18422345, ECO 0000269|PubMed 19655786, ECO 0000269|PubMed 8444173}. # CAUTION Was originally thought to be involved in transcription. {ECO 0000305}. # CDD cd03352 LbH_LpxD # ENZYME REGULATION Inhibited by divalent cations such as Ca(2+) and Mg(2+). {ECO:0000269|PubMed 18422345}. # EcoGene EG10316 lpxD # FUNCTION LPXD_ECOLI Catalyzes the N-acylation of UDP-3-O- (hydroxytetradecanoyl)glucosamine using 3-hydroxytetradecanoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Prefers (3R)-3- hydroxytetradecanoyl-ACP over (3R)-3-hydroxyhexadecanoyl-ACP as the acyl donor in vitro, which is consistent with the structure of E.coli lipid A that contains over 95% (R)-3-hydroxytetradecanoate at the 2 and 2' positions. {ECO 0000269|PubMed 19655786, ECO 0000269|PubMed 8444173}. # GO_component GO:0005737 cytoplasm; IDA:EcoCyc. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0016410 N-acyltransferase activity; IDA:EcoliWiki. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0043764 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0103118 UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase activity; IEA:UniProtKB-EC. # GO_process GO:0009245 lipid A biosynthetic process; IMP:EcoliWiki. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # HAMAP MF_00523 LpxD # IntAct P21645 55 # InterPro IPR001451 Hexapep # InterPro IPR007691 LpxD # InterPro IPR011004 Trimer_LpxA-like # InterPro IPR018357 Hexapep_transf_CS # InterPro IPR020573 UDP_GlcNAc_AcTrfase_non-rep # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # KEGG_Pathway ko00540 Lipopolysaccharide biosynthesis # Organism LPXD_ECOLI Escherichia coli (strain K12) # PATHWAY Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine step 3/6. # PATRIC 32115469 VBIEscCol129921_0186 # PDB 3EH0 X-ray; 2.60 A; A/B/C=1-341 # PDB 4IHF X-ray; 2.10 A; A/B/C/D/E/F=3-341 # PDB 4IHG X-ray; 2.89 A; A/B/C/D/E/F=3-341 # PDB 4IHH X-ray; 2.13 A; A/B/C/D/E/F=3-341 # PIR S13729 S13729 # PROSITE PS00101 HEXAPEP_TRANSFERASES; 4 # Pfam PF00132 Hexapep; 3 # Pfam PF04613 LpxD # Pfam PF14602 Hexapep_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LPXD_ECOLI UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase # RefSeq NP_414721 NC_000913.3 # RefSeq WP_001139279 NZ_LN832404.1 # SIMILARITY Belongs to the transferase hexapeptide repeat family. LpxD subfamily. {ECO 0000305}. # SUBUNIT LPXD_ECOLI Homotrimer. {ECO 0000269|PubMed 18422345, ECO 0000269|PubMed 19655786}. # SUPFAM SSF51161 SSF51161 # TIGRFAMs TIGR01853 lipid_A_lpxD # UniPathway UPA00359 UER00479 # eggNOG COG1044 LUCA # eggNOG ENOG4105D7M Bacteria BLAST swissprot:LPXD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LPXD_ECOLI BioCyc ECOL316407:JW0174-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0174-MONOMER BioCyc EcoCyc:UDPHYDROXYMYRGLUCOSAMNACETYLTRANS-MONO http://biocyc.org/getid?id=EcoCyc:UDPHYDROXYMYRGLUCOSAMNACETYLTRANS-MONO BioCyc MetaCyc:UDPHYDROXYMYRGLUCOSAMNACETYLTRANS-MONO http://biocyc.org/getid?id=MetaCyc:UDPHYDROXYMYRGLUCOSAMNACETYLTRANS-MONO COG COG1044 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1044 DIP DIP-10124N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10124N DOI 10.1021/bi800240r http://dx.doi.org/10.1021/bi800240r DOI 10.1021/bi901025v http://dx.doi.org/10.1021/bi901025v DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1992.tb01532.x http://dx.doi.org/10.1111/j.1365-2958.1992.tb01532.x DOI 10.1111/j.1432-1033.1993.tb17670.x http://dx.doi.org/10.1111/j.1432-1033.1993.tb17670.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.191 http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.191 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EMBL X54797 http://www.ebi.ac.uk/ena/data/view/X54797 ENZYME 2.3.1.191 http://enzyme.expasy.org/EC/2.3.1.191 EchoBASE EB0312 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0312 EcoGene EG10316 http://www.ecogene.org/geneInfo.php?eg_id=EG10316 EnsemblBacteria AAC73290 http://www.ensemblgenomes.org/id/AAC73290 EnsemblBacteria AAC73290 http://www.ensemblgenomes.org/id/AAC73290 EnsemblBacteria BAA77854 http://www.ensemblgenomes.org/id/BAA77854 EnsemblBacteria BAA77854 http://www.ensemblgenomes.org/id/BAA77854 EnsemblBacteria BAA77854 http://www.ensemblgenomes.org/id/BAA77854 EnsemblBacteria b0179 http://www.ensemblgenomes.org/id/b0179 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0016410 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016410 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0043764 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043764 GO_function GO:0103118 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0103118 GO_process GO:0009245 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009245 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 944882 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944882 HAMAP MF_00523 http://hamap.expasy.org/unirule/MF_00523 HOGENOM HOG000294339 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000294339&db=HOGENOM6 InParanoid P21645 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P21645 IntAct P21645 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P21645* IntEnz 2.3.1.191 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.191 InterPro IPR001451 http://www.ebi.ac.uk/interpro/entry/IPR001451 InterPro IPR007691 http://www.ebi.ac.uk/interpro/entry/IPR007691 InterPro IPR011004 http://www.ebi.ac.uk/interpro/entry/IPR011004 InterPro IPR018357 http://www.ebi.ac.uk/interpro/entry/IPR018357 InterPro IPR020573 http://www.ebi.ac.uk/interpro/entry/IPR020573 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Gene ecj:JW0174 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0174 KEGG_Gene eco:b0179 http://www.genome.jp/dbget-bin/www_bget?eco:b0179 KEGG_Orthology KO:K02536 http://www.genome.jp/dbget-bin/www_bget?KO:K02536 KEGG_Pathway ko00540 http://www.genome.jp/kegg-bin/show_pathway?ko00540 KEGG_Reaction rn:R04550 http://www.genome.jp/dbget-bin/www_bget?rn:R04550 MINT MINT-1218299 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1218299 OMA SYPAKIM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SYPAKIM PDB 3EH0 http://www.ebi.ac.uk/pdbe-srv/view/entry/3EH0 PDB 4IHF http://www.ebi.ac.uk/pdbe-srv/view/entry/4IHF PDB 4IHG http://www.ebi.ac.uk/pdbe-srv/view/entry/4IHG PDB 4IHH http://www.ebi.ac.uk/pdbe-srv/view/entry/4IHH PDBsum 3EH0 http://www.ebi.ac.uk/pdbsum/3EH0 PDBsum 4IHF http://www.ebi.ac.uk/pdbsum/4IHF PDBsum 4IHG http://www.ebi.ac.uk/pdbsum/4IHG PDBsum 4IHH http://www.ebi.ac.uk/pdbsum/4IHH PROSITE PS00101 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00101 PSORT swissprot:LPXD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LPXD_ECOLI PSORT-B swissprot:LPXD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LPXD_ECOLI PSORT2 swissprot:LPXD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LPXD_ECOLI Pfam PF00132 http://pfam.xfam.org/family/PF00132 Pfam PF04613 http://pfam.xfam.org/family/PF04613 Pfam PF14602 http://pfam.xfam.org/family/PF14602 Phobius swissprot:LPXD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LPXD_ECOLI PhylomeDB P21645 http://phylomedb.org/?seqid=P21645 ProteinModelPortal P21645 http://www.proteinmodelportal.org/query/uniprot/P21645 PubMed 1429432 http://www.ncbi.nlm.nih.gov/pubmed/1429432 PubMed 1602961 http://www.ncbi.nlm.nih.gov/pubmed/1602961 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18422345 http://www.ncbi.nlm.nih.gov/pubmed/18422345 PubMed 19655786 http://www.ncbi.nlm.nih.gov/pubmed/19655786 PubMed 1987124 http://www.ncbi.nlm.nih.gov/pubmed/1987124 PubMed 8366125 http://www.ncbi.nlm.nih.gov/pubmed/8366125 PubMed 8444173 http://www.ncbi.nlm.nih.gov/pubmed/8444173 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414721 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414721 RefSeq WP_001139279 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001139279 SMR P21645 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P21645 STRING 511145.b0179 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0179&targetmode=cogs STRING COG1044 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1044&targetmode=cogs SUPFAM SSF51161 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51161 TIGRFAMs TIGR01853 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01853 UniProtKB LPXD_ECOLI http://www.uniprot.org/uniprot/LPXD_ECOLI UniProtKB-AC P21645 http://www.uniprot.org/uniprot/P21645 charge swissprot:LPXD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LPXD_ECOLI eggNOG COG1044 http://eggnogapi.embl.de/nog_data/html/tree/COG1044 eggNOG ENOG4105D7M http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D7M epestfind swissprot:LPXD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LPXD_ECOLI garnier swissprot:LPXD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LPXD_ECOLI helixturnhelix swissprot:LPXD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LPXD_ECOLI hmoment swissprot:LPXD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LPXD_ECOLI iep swissprot:LPXD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LPXD_ECOLI inforesidue swissprot:LPXD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LPXD_ECOLI octanol swissprot:LPXD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LPXD_ECOLI pepcoil swissprot:LPXD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LPXD_ECOLI pepdigest swissprot:LPXD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LPXD_ECOLI pepinfo swissprot:LPXD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LPXD_ECOLI pepnet swissprot:LPXD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LPXD_ECOLI pepstats swissprot:LPXD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LPXD_ECOLI pepwheel swissprot:LPXD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LPXD_ECOLI pepwindow swissprot:LPXD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LPXD_ECOLI sigcleave swissprot:LPXD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LPXD_ECOLI ## Database ID URL or Descriptions # AltName PYRH_ECOLI Uridine monophosphate kinase # BIOPHYSICOCHEMICAL PROPERTIES PYRH_ECOLI Kinetic parameters KM=120 uM for ATP {ECO 0000269|PubMed 7711027}; KM=50 uM for UMP {ECO 0000269|PubMed 7711027}; Vmax=96 umol/min/mg enzyme {ECO 0000269|PubMed 7711027}; # BRENDA 2.7.4.22 2026 # BioGrid 4262225 6 # CATALYTIC ACTIVITY PYRH_ECOLI ATP + UMP = ADP + UDP. # ENZYME REGULATION PYRH_ECOLI Allosterically activated by GTP. Competitively inhibited by magnesium-free UTP. Magnesium-bound UTP is unable to inhibit enzyme activity. {ECO 0000269|PubMed 15857829, ECO 0000269|PubMed 17210578}. # EcoGene EG11539 pyrH # FUNCTION PYRH_ECOLI Catalyzes the reversible phosphorylation of UMP to UDP, with ATP as the most efficient phosphate donor. {ECO 0000269|PubMed 7711027}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0033862 UMP kinase activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0006221 pyrimidine nucleotide biosynthetic process; IDA:EcoCyc. # GO_process GO:0006225 UDP biosynthetic process; IBA:GO_Central. # GO_process GO:0044210 'de novo' CTP biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.1160.10 -; 1. # HAMAP MF_01220_B PyrH_B # IntAct P0A7E9 54 # InterPro IPR001048 Asp/Glu/Uridylate_kinase # InterPro IPR011817 Uridylate_kinase # InterPro IPR015963 Uridylate_kinase_bac # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00240 Pyrimidine metabolism # MISCELLANEOUS PYRH_ECOLI The peripheral distribution of PyrH is related most probably to its role in the synthesis of membrane sugar components. # Organism PYRH_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21499:SF23 PTHR21499:SF23 # PATHWAY Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route) step 1/1. # PATRIC 32115451 VBIEscCol129921_0177 # PDB 2BND X-ray; 2.60 A; A/B=1-241 # PDB 2BNE X-ray; 2.30 A; A/B=1-241 # PDB 2BNF X-ray; 2.45 A; A/B=1-241 # PDB 2V4Y X-ray; 2.80 A; A/B/C/D/E/F=1-241 # PIR B45269 B45269 # PIRSF PIRSF005650 Uridylate_kin # Pfam PF00696 AA_kinase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PYRH_ECOLI Uridylate kinase # RefSeq NP_414713 NC_000913.3 # RefSeq WP_000224573 NZ_LN832404.1 # SIMILARITY Belongs to the UMP kinase family. {ECO 0000305}. # SUBCELLULAR LOCATION PYRH_ECOLI Cytoplasm {ECO 0000269|PubMed 9922246}. Note=Is predominantly localized near the bacterial membranes. # SUBUNIT PYRH_ECOLI Homohexamer. {ECO 0000269|PubMed 15857829, ECO 0000269|PubMed 7711027}. # SUPFAM SSF53633 SSF53633 # TIGRFAMs TIGR02075 pyrH_bact # UniPathway UPA00159 UER00275 # eggNOG COG0528 LUCA # eggNOG ENOG4105C41 Bacteria BLAST swissprot:PYRH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PYRH_ECOLI BioCyc ECOL316407:JW0166-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0166-MONOMER BioCyc EcoCyc:UMPKI-MONOMER http://biocyc.org/getid?id=EcoCyc:UMPKI-MONOMER BioCyc MetaCyc:UMPKI-MONOMER http://biocyc.org/getid?id=MetaCyc:UMPKI-MONOMER COG COG0528 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0528 DIP DIP-31830N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31830N DOI 10.1007/BF00283870 http://dx.doi.org/10.1007/BF00283870 DOI 10.1021/bi00015a018 http://dx.doi.org/10.1021/bi00015a018 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M501849200 http://dx.doi.org/10.1074/jbc.M501849200 DOI 10.1074/jbc.M606963200 http://dx.doi.org/10.1074/jbc.M606963200 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.4.22 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.4.22 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D13334 http://www.ebi.ac.uk/ena/data/view/D13334 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EMBL X78809 http://www.ebi.ac.uk/ena/data/view/X78809 ENZYME 2.7.4.22 http://enzyme.expasy.org/EC/2.7.4.22 EchoBASE EB1501 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1501 EcoGene EG11539 http://www.ecogene.org/geneInfo.php?eg_id=EG11539 EnsemblBacteria AAC73282 http://www.ensemblgenomes.org/id/AAC73282 EnsemblBacteria AAC73282 http://www.ensemblgenomes.org/id/AAC73282 EnsemblBacteria BAB96747 http://www.ensemblgenomes.org/id/BAB96747 EnsemblBacteria BAB96747 http://www.ensemblgenomes.org/id/BAB96747 EnsemblBacteria BAB96747 http://www.ensemblgenomes.org/id/BAB96747 EnsemblBacteria b0171 http://www.ensemblgenomes.org/id/b0171 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0033862 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033862 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0006221 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006221 GO_process GO:0006225 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006225 GO_process GO:0044210 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044210 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.1160.10 http://www.cathdb.info/version/latest/superfamily/3.40.1160.10 GeneID 944989 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944989 HAMAP MF_01220_B http://hamap.expasy.org/unirule/MF_01220_B HOGENOM HOG000047187 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000047187&db=HOGENOM6 InParanoid P0A7E9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7E9 IntAct P0A7E9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7E9* IntEnz 2.7.4.22 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.4.22 InterPro IPR001048 http://www.ebi.ac.uk/interpro/entry/IPR001048 InterPro IPR011817 http://www.ebi.ac.uk/interpro/entry/IPR011817 InterPro IPR015963 http://www.ebi.ac.uk/interpro/entry/IPR015963 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0166 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0166 KEGG_Gene eco:b0171 http://www.genome.jp/dbget-bin/www_bget?eco:b0171 KEGG_Orthology KO:K09903 http://www.genome.jp/dbget-bin/www_bget?KO:K09903 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Reaction rn:R00158 http://www.genome.jp/dbget-bin/www_bget?rn:R00158 MINT MINT-1222953 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1222953 OMA KGLKVMD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KGLKVMD PANTHER PTHR21499:SF23 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21499:SF23 PDB 2BND http://www.ebi.ac.uk/pdbe-srv/view/entry/2BND PDB 2BNE http://www.ebi.ac.uk/pdbe-srv/view/entry/2BNE PDB 2BNF http://www.ebi.ac.uk/pdbe-srv/view/entry/2BNF PDB 2V4Y http://www.ebi.ac.uk/pdbe-srv/view/entry/2V4Y PDBsum 2BND http://www.ebi.ac.uk/pdbsum/2BND PDBsum 2BNE http://www.ebi.ac.uk/pdbsum/2BNE PDBsum 2BNF http://www.ebi.ac.uk/pdbsum/2BNF PDBsum 2V4Y http://www.ebi.ac.uk/pdbsum/2V4Y PSORT swissprot:PYRH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PYRH_ECOLI PSORT-B swissprot:PYRH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PYRH_ECOLI PSORT2 swissprot:PYRH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PYRH_ECOLI Pfam PF00696 http://pfam.xfam.org/family/PF00696 Phobius swissprot:PYRH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PYRH_ECOLI PhylomeDB P0A7E9 http://phylomedb.org/?seqid=P0A7E9 ProteinModelPortal P0A7E9 http://www.proteinmodelportal.org/query/uniprot/P0A7E9 PubMed 1447125 http://www.ncbi.nlm.nih.gov/pubmed/1447125 PubMed 15857829 http://www.ncbi.nlm.nih.gov/pubmed/15857829 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17210578 http://www.ncbi.nlm.nih.gov/pubmed/17210578 PubMed 7711027 http://www.ncbi.nlm.nih.gov/pubmed/7711027 PubMed 8190075 http://www.ncbi.nlm.nih.gov/pubmed/8190075 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9457846 http://www.ncbi.nlm.nih.gov/pubmed/9457846 PubMed 9922246 http://www.ncbi.nlm.nih.gov/pubmed/9922246 RefSeq NP_414713 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414713 RefSeq WP_000224573 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000224573 SMR P0A7E9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7E9 STRING 511145.b0171 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0171&targetmode=cogs STRING COG0528 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0528&targetmode=cogs SUPFAM SSF53633 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53633 TIGRFAMs TIGR02075 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02075 UniProtKB PYRH_ECOLI http://www.uniprot.org/uniprot/PYRH_ECOLI UniProtKB-AC P0A7E9 http://www.uniprot.org/uniprot/P0A7E9 charge swissprot:PYRH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PYRH_ECOLI eggNOG COG0528 http://eggnogapi.embl.de/nog_data/html/tree/COG0528 eggNOG ENOG4105C41 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C41 epestfind swissprot:PYRH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PYRH_ECOLI garnier swissprot:PYRH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PYRH_ECOLI helixturnhelix swissprot:PYRH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PYRH_ECOLI hmoment swissprot:PYRH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PYRH_ECOLI iep swissprot:PYRH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PYRH_ECOLI inforesidue swissprot:PYRH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PYRH_ECOLI octanol swissprot:PYRH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PYRH_ECOLI pepcoil swissprot:PYRH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PYRH_ECOLI pepdigest swissprot:PYRH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PYRH_ECOLI pepinfo swissprot:PYRH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PYRH_ECOLI pepnet swissprot:PYRH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PYRH_ECOLI pepstats swissprot:PYRH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PYRH_ECOLI pepwheel swissprot:PYRH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PYRH_ECOLI pepwindow swissprot:PYRH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PYRH_ECOLI sigcleave swissprot:PYRH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PYRH_ECOLI ## Database ID URL or Descriptions # BioGrid 4261385 14 # EcoGene EG12333 yadS # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR005115 UPF0126 # Organism YADS_ECOLI Escherichia coli (strain K12) # PATRIC 32115423 VBIEscCol129921_0163 # PIR S45226 S45226 # Pfam PF03458 UPF0126; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YADS_ECOLI UPF0126 inner membrane protein YadS # RefSeq NP_414699 NC_000913.3 # RefSeq WP_000964221 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0126 family. {ECO 0000305}. # SUBCELLULAR LOCATION YADS_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG COG2860 LUCA # eggNOG ENOG4105EN6 Bacteria BLAST swissprot:YADS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YADS_ECOLI BioCyc ECOL316407:JW0153-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0153-MONOMER BioCyc EcoCyc:EG12333-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12333-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EchoBASE EB2237 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2237 EcoGene EG12333 http://www.ecogene.org/geneInfo.php?eg_id=EG12333 EnsemblBacteria AAC73268 http://www.ensemblgenomes.org/id/AAC73268 EnsemblBacteria AAC73268 http://www.ensemblgenomes.org/id/AAC73268 EnsemblBacteria BAB96734 http://www.ensemblgenomes.org/id/BAB96734 EnsemblBacteria BAB96734 http://www.ensemblgenomes.org/id/BAB96734 EnsemblBacteria BAB96734 http://www.ensemblgenomes.org/id/BAB96734 EnsemblBacteria b0157 http://www.ensemblgenomes.org/id/b0157 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 949062 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949062 HOGENOM HOG000218258 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218258&db=HOGENOM6 InParanoid P0AFP0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFP0 InterPro IPR005115 http://www.ebi.ac.uk/interpro/entry/IPR005115 KEGG_Gene ecj:JW0153 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0153 KEGG_Gene eco:b0157 http://www.genome.jp/dbget-bin/www_bget?eco:b0157 OMA TYLWVIF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TYLWVIF PSORT swissprot:YADS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YADS_ECOLI PSORT-B swissprot:YADS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YADS_ECOLI PSORT2 swissprot:YADS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YADS_ECOLI Pfam PF03458 http://pfam.xfam.org/family/PF03458 Phobius swissprot:YADS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YADS_ECOLI PhylomeDB P0AFP0 http://phylomedb.org/?seqid=P0AFP0 ProteinModelPortal P0AFP0 http://www.proteinmodelportal.org/query/uniprot/P0AFP0 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414699 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414699 RefSeq WP_000964221 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000964221 STRING 511145.b0157 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0157&targetmode=cogs UniProtKB YADS_ECOLI http://www.uniprot.org/uniprot/YADS_ECOLI UniProtKB-AC P0AFP0 http://www.uniprot.org/uniprot/P0AFP0 charge swissprot:YADS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YADS_ECOLI eggNOG COG2860 http://eggnogapi.embl.de/nog_data/html/tree/COG2860 eggNOG ENOG4105EN6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EN6 epestfind swissprot:YADS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YADS_ECOLI garnier swissprot:YADS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YADS_ECOLI helixturnhelix swissprot:YADS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YADS_ECOLI hmoment swissprot:YADS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YADS_ECOLI iep swissprot:YADS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YADS_ECOLI inforesidue swissprot:YADS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YADS_ECOLI octanol swissprot:YADS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YADS_ECOLI pepcoil swissprot:YADS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YADS_ECOLI pepdigest swissprot:YADS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YADS_ECOLI pepinfo swissprot:YADS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YADS_ECOLI pepnet swissprot:YADS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YADS_ECOLI pepstats swissprot:YADS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YADS_ECOLI pepwheel swissprot:YADS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YADS_ECOLI pepwindow swissprot:YADS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YADS_ECOLI sigcleave swissprot:YADS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YADS_ECOLI ## Database ID URL or Descriptions # AltName HIS4_ECOLI Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase # BioGrid 4260420 26 # CATALYTIC ACTIVITY HIS4_ECOLI 1-(5-phospho-beta-D-ribosyl)-5-((5-phospho- beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5- ((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5- phospho-beta-D-ribosyl)imidazole-4-carboxamide. # CDD cd04732 HisA # EcoGene EG10444 hisA # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003949 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity; IDA:EcoCyc. # GO_process GO:0000105 histidine biosynthetic process; IDA:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.20.20.70 -; 1. # HAMAP MF_01014 HisA # IntAct P10371 3 # InterPro IPR006062 His_biosynth # InterPro IPR006063 HisA # InterPro IPR011060 RibuloseP-bd_barrel # InterPro IPR013785 Aldolase_TIM # InterPro IPR023016 Isoase_HisA # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00340 Histidine metabolism # Organism HIS4_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-histidine biosynthesis; L- histidine from 5-phospho-alpha-D-ribose 1-diphosphate step 4/9. # PATRIC 32119383 VBIEscCol129921_2101 # PIR G64967 ISECIC # Pfam PF00977 His_biosynth # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HIS4_ECOLI 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase # RefSeq NP_416528 NC_000913.3 # RefSeq WP_000586462 NZ_LN832404.1 # SIMILARITY Belongs to the HisA/HisF family. {ECO 0000305}. # SUBCELLULAR LOCATION HIS4_ECOLI Cytoplasm. # SUBUNIT HIS4_ECOLI Monomer. # SUPFAM SSF51366 SSF51366 # TIGRFAMs TIGR00007 TIGR00007 # UniPathway UPA00031 UER00009 # eggNOG COG0106 LUCA # eggNOG ENOG4105CJV Bacteria BLAST swissprot:HIS4_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HIS4_ECOLI BioCyc ECOL316407:JW2006-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2006-MONOMER BioCyc EcoCyc:PRIBFAICARPISOM-MONOMER http://biocyc.org/getid?id=EcoCyc:PRIBFAICARPISOM-MONOMER BioCyc MetaCyc:PRIBFAICARPISOM-MONOMER http://biocyc.org/getid?id=MetaCyc:PRIBFAICARPISOM-MONOMER COG COG0106 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0106 DOI 10.1016/0022-2836(88)90194-5 http://dx.doi.org/10.1016/0022-2836(88)90194-5 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.3.1.16 http://www.genome.jp/dbget-bin/www_bget?EC:5.3.1.16 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X13462 http://www.ebi.ac.uk/ena/data/view/X13462 ENZYME 5.3.1.16 http://enzyme.expasy.org/EC/5.3.1.16 EchoBASE EB0439 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0439 EcoGene EG10444 http://www.ecogene.org/geneInfo.php?eg_id=EG10444 EnsemblBacteria AAC75085 http://www.ensemblgenomes.org/id/AAC75085 EnsemblBacteria AAC75085 http://www.ensemblgenomes.org/id/AAC75085 EnsemblBacteria BAA15855 http://www.ensemblgenomes.org/id/BAA15855 EnsemblBacteria BAA15855 http://www.ensemblgenomes.org/id/BAA15855 EnsemblBacteria BAA15855 http://www.ensemblgenomes.org/id/BAA15855 EnsemblBacteria b2024 http://www.ensemblgenomes.org/id/b2024 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003949 GO_process GO:0000105 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000105 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 946521 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946521 HAMAP MF_01014 http://hamap.expasy.org/unirule/MF_01014 HOGENOM HOG000224614 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000224614&db=HOGENOM6 InParanoid P10371 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P10371 IntAct P10371 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P10371* IntEnz 5.3.1.16 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.3.1.16 InterPro IPR006062 http://www.ebi.ac.uk/interpro/entry/IPR006062 InterPro IPR006063 http://www.ebi.ac.uk/interpro/entry/IPR006063 InterPro IPR011060 http://www.ebi.ac.uk/interpro/entry/IPR011060 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR023016 http://www.ebi.ac.uk/interpro/entry/IPR023016 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2006 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2006 KEGG_Gene eco:b2024 http://www.genome.jp/dbget-bin/www_bget?eco:b2024 KEGG_Orthology KO:K01814 http://www.genome.jp/dbget-bin/www_bget?KO:K01814 KEGG_Pathway ko00340 http://www.genome.jp/kegg-bin/show_pathway?ko00340 KEGG_Reaction rn:R04640 http://www.genome.jp/dbget-bin/www_bget?rn:R04640 OMA EWLHLVD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EWLHLVD PSORT swissprot:HIS4_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HIS4_ECOLI PSORT-B swissprot:HIS4_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HIS4_ECOLI PSORT2 swissprot:HIS4_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HIS4_ECOLI Pfam PF00977 http://pfam.xfam.org/family/PF00977 Phobius swissprot:HIS4_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HIS4_ECOLI PhylomeDB P10371 http://phylomedb.org/?seqid=P10371 ProteinModelPortal P10371 http://www.proteinmodelportal.org/query/uniprot/P10371 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3062174 http://www.ncbi.nlm.nih.gov/pubmed/3062174 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416528 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416528 RefSeq WP_000586462 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000586462 SMR P10371 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P10371 STRING 511145.b2024 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2024&targetmode=cogs STRING COG0106 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0106&targetmode=cogs SUPFAM SSF51366 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51366 SWISS-2DPAGE P10371 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P10371 TIGRFAMs TIGR00007 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00007 UniProtKB HIS4_ECOLI http://www.uniprot.org/uniprot/HIS4_ECOLI UniProtKB-AC P10371 http://www.uniprot.org/uniprot/P10371 charge swissprot:HIS4_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HIS4_ECOLI eggNOG COG0106 http://eggnogapi.embl.de/nog_data/html/tree/COG0106 eggNOG ENOG4105CJV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CJV epestfind swissprot:HIS4_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HIS4_ECOLI garnier swissprot:HIS4_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HIS4_ECOLI helixturnhelix swissprot:HIS4_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HIS4_ECOLI hmoment swissprot:HIS4_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HIS4_ECOLI iep swissprot:HIS4_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HIS4_ECOLI inforesidue swissprot:HIS4_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HIS4_ECOLI octanol swissprot:HIS4_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HIS4_ECOLI pepcoil swissprot:HIS4_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HIS4_ECOLI pepdigest swissprot:HIS4_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HIS4_ECOLI pepinfo swissprot:HIS4_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HIS4_ECOLI pepnet swissprot:HIS4_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HIS4_ECOLI pepstats swissprot:HIS4_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HIS4_ECOLI pepwheel swissprot:HIS4_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HIS4_ECOLI pepwindow swissprot:HIS4_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HIS4_ECOLI sigcleave swissprot:HIS4_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HIS4_ECOLI ## Database ID URL or Descriptions # AltName ATOC_ECOLI Ornithine decarboxylase antizyme # AltName ATOC_ECOLI Ornithine/arginine decarboxylase inhibitor # EcoGene EG11668 atoC # FUNCTION ATOC_ECOLI Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0008073 ornithine decarboxylase inhibitor activity; IDA:EcoCyc. # GO_function GO:0043565 sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0000160 phosphorelay signal transduction system; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0010967 regulation of polyamine biosynthetic process; IDA:EcoCyc. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0030234 enzyme regulator activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.60 -; 1. # Gene3D 3.40.50.300 -; 1. # IntAct Q06065 10 # InterPro IPR001789 Sig_transdc_resp-reg_receiver # InterPro IPR002078 Sigma_54_int # InterPro IPR002197 HTH_Fis # InterPro IPR003593 AAA+_ATPase # InterPro IPR009057 Homeodomain-like # InterPro IPR011006 CheY-like_superfamily # InterPro IPR025662 Sigma_54_int_dom_ATP-bd_1 # InterPro IPR025943 Sigma_54_int_dom_ATP-bd_2 # InterPro IPR025944 Sigma_54_int_dom_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02022 M00500 AtoS-AtoC (complexed poly-(R)-3-hydroxybutyrate biosynthesis) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # Organism ATOC_ECOLI Escherichia coli (strain K12) # PATRIC 32119799 VBIEscCol129921_2309 # PIR B64992 B64992 # PRINTS PR01590 HTHFIS # PROSITE PS00675 SIGMA54_INTERACT_1 # PROSITE PS00676 SIGMA54_INTERACT_2 # PROSITE PS00688 SIGMA54_INTERACT_3 # PROSITE PS50045 SIGMA54_INTERACT_4 # PROSITE PS50110 RESPONSE_REGULATORY # PTM ATOC_ECOLI Phosphorylated by AtoS. {ECO 0000305}. # PTM ATOC_ECOLI The N-terminus is blocked. # Pfam PF00072 Response_reg # Pfam PF00158 Sigma54_activat # Pfam PF02954 HTH_8 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ATOC_ECOLI Acetoacetate metabolism regulatory protein AtoC # RefSeq NP_416724 NC_000913.3 # RefSeq WP_000125282 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA23450.1; Type=Frameshift; Positions=92; Evidence={ECO 0000305}; # SIMILARITY Contains 1 response regulatory domain. {ECO:0000255|PROSITE-ProRule PRU00169}. # SIMILARITY Contains 1 sigma-54 factor interaction domain. {ECO:0000255|PROSITE-ProRule PRU00193}. # SMART SM00382 AAA # SMART SM00448 REC # SUBCELLULAR LOCATION ATOC_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF46689 SSF46689 # SUPFAM SSF52172 SSF52172 # SUPFAM SSF52540 SSF52540 # eggNOG COG2204 LUCA # eggNOG ENOG4105C1W Bacteria BLAST swissprot:ATOC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ATOC_ECOLI BioCyc ECOL316407:JW2214-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2214-MONOMER BioCyc EcoCyc:ATOC-MONOMER http://biocyc.org/getid?id=EcoCyc:ATOC-MONOMER COG COG2204 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2204 DIP DIP-9190N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9190N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.90.15.7129 http://dx.doi.org/10.1073/pnas.90.15.7129 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L13078 http://www.ebi.ac.uk/ena/data/view/L13078 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U17902 http://www.ebi.ac.uk/ena/data/view/U17902 EchoBASE EB1619 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1619 EcoGene EG11668 http://www.ecogene.org/geneInfo.php?eg_id=EG11668 EnsemblBacteria AAC75280 http://www.ensemblgenomes.org/id/AAC75280 EnsemblBacteria AAC75280 http://www.ensemblgenomes.org/id/AAC75280 EnsemblBacteria BAA16016 http://www.ensemblgenomes.org/id/BAA16016 EnsemblBacteria BAA16016 http://www.ensemblgenomes.org/id/BAA16016 EnsemblBacteria BAA16016 http://www.ensemblgenomes.org/id/BAA16016 EnsemblBacteria b2220 http://www.ensemblgenomes.org/id/b2220 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008073 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008073 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0010967 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010967 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947444 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947444 HOGENOM HOG000058489 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000058489&db=HOGENOM6 InParanoid Q06065 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q06065 IntAct Q06065 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q06065* InterPro IPR001789 http://www.ebi.ac.uk/interpro/entry/IPR001789 InterPro IPR002078 http://www.ebi.ac.uk/interpro/entry/IPR002078 InterPro IPR002197 http://www.ebi.ac.uk/interpro/entry/IPR002197 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR011006 http://www.ebi.ac.uk/interpro/entry/IPR011006 InterPro IPR025662 http://www.ebi.ac.uk/interpro/entry/IPR025662 InterPro IPR025943 http://www.ebi.ac.uk/interpro/entry/IPR025943 InterPro IPR025944 http://www.ebi.ac.uk/interpro/entry/IPR025944 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW2214 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2214 KEGG_Gene eco:b2220 http://www.genome.jp/dbget-bin/www_bget?eco:b2220 KEGG_Orthology KO:K07714 http://www.genome.jp/dbget-bin/www_bget?KO:K07714 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA IAEMPLQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IAEMPLQ PRINTS PR01590 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01590 PROSITE PS00675 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00675 PROSITE PS00676 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00676 PROSITE PS00688 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00688 PROSITE PS50045 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50045 PROSITE PS50110 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50110 PSORT swissprot:ATOC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ATOC_ECOLI PSORT-B swissprot:ATOC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ATOC_ECOLI PSORT2 swissprot:ATOC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ATOC_ECOLI Pfam PF00072 http://pfam.xfam.org/family/PF00072 Pfam PF00158 http://pfam.xfam.org/family/PF00158 Pfam PF02954 http://pfam.xfam.org/family/PF02954 Phobius swissprot:ATOC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ATOC_ECOLI PhylomeDB Q06065 http://phylomedb.org/?seqid=Q06065 ProteinModelPortal Q06065 http://www.proteinmodelportal.org/query/uniprot/Q06065 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8346225 http://www.ncbi.nlm.nih.gov/pubmed/8346225 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416724 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416724 RefSeq WP_000125282 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000125282 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMART SM00448 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00448 SMR Q06065 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q06065 STRING 511145.b2220 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2220&targetmode=cogs STRING COG2204 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2204&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF52172 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52172 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB ATOC_ECOLI http://www.uniprot.org/uniprot/ATOC_ECOLI UniProtKB-AC Q06065 http://www.uniprot.org/uniprot/Q06065 charge swissprot:ATOC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ATOC_ECOLI eggNOG COG2204 http://eggnogapi.embl.de/nog_data/html/tree/COG2204 eggNOG ENOG4105C1W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C1W epestfind swissprot:ATOC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ATOC_ECOLI garnier swissprot:ATOC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ATOC_ECOLI helixturnhelix swissprot:ATOC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ATOC_ECOLI hmoment swissprot:ATOC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ATOC_ECOLI iep swissprot:ATOC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ATOC_ECOLI inforesidue swissprot:ATOC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ATOC_ECOLI octanol swissprot:ATOC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ATOC_ECOLI pepcoil swissprot:ATOC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ATOC_ECOLI pepdigest swissprot:ATOC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ATOC_ECOLI pepinfo swissprot:ATOC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ATOC_ECOLI pepnet swissprot:ATOC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ATOC_ECOLI pepstats swissprot:ATOC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ATOC_ECOLI pepwheel swissprot:ATOC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ATOC_ECOLI pepwindow swissprot:ATOC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ATOC_ECOLI sigcleave swissprot:ATOC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ATOC_ECOLI ## Database ID URL or Descriptions # AltName 1,4-alpha-D-glucan 1,4-alpha-D-glucan 6-glucosyl-transferase # AltName GLGB_ECOLI Alpha-(1->4)-glucan branching enzyme # AltName GLGB_ECOLI Glycogen branching enzyme # BioGrid 4262503 311 # CATALYTIC ACTIVITY GLGB_ECOLI Transfers a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain. # CAZy CBM48 Carbohydrate-Binding Module Family 48 # CAZy GH13 Glycoside Hydrolase Family 13 # EcoGene EG10378 glgB # FUNCTION GLGB_ECOLI Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position. {ECO 0000250}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003844 1,4-alpha-glucan branching enzyme activity; IDA:EcoCyc. # GO_function GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro. # GO_function GO:0043169 cation binding; IEA:InterPro. # GO_process GO:0005978 glycogen biosynthetic process; IMP:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # Gene3D 2.60.40.10 -; 2. # Gene3D 2.60.40.1180 -; 1. # Gene3D 3.20.20.80 -; 1. # HAMAP MF_00685 GlgB # IntAct P07762 13 # InterPro IPR004193 Glyco_hydro_13_N # InterPro IPR006047 Glyco_hydro_13_cat_dom # InterPro IPR006048 A-amylase/branching_C # InterPro IPR006407 GlgB # InterPro IPR013780 Glyco_hydro_b # InterPro IPR013781 Glyco_hydro_catalytic_dom # InterPro IPR013783 Ig-like_fold # InterPro IPR014756 Ig_E-set # InterPro IPR015902 Glyco_hydro_13 # InterPro IPR017853 Glycoside_hydrolase_SF # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00500 Starch and sucrose metabolism # Organism GLGB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10357 PTHR10357 # PATHWAY GLGB_ECOLI Glycan biosynthesis; glycogen biosynthesis. # PATRIC 32122304 VBIEscCol129921_3529 # PDB 1GTY Model; -; A=24-103 # PDB 1M7X X-ray; 2.30 A; A/B/C/D=113-728 # PDB 4LPC X-ray; 2.39 A; A/B/C/D=117-728 # PDB 4LQ1 X-ray; 2.55 A; A/B/C/D=117-728 # PDB 5E6Y X-ray; 2.60 A; A/B/C/D=117-728 # PDB 5E6Z X-ray; 1.88 A; A/B/C/D=117-728 # PDB 5E70 X-ray; 2.33 A; A/B/C/D=117-728 # PIR A25498 NQECA # PIRSF PIRSF000463 GlgB # Pfam PF00128 Alpha-amylase # Pfam PF02806 Alpha-amylase_C # Pfam PF02922 CBM_48 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLGB_ECOLI 1,4-alpha-glucan branching enzyme GlgB # RefSeq NP_417890 NC_000913.3 # RefSeq WP_001283723 NZ_LN832404.1 # SIMILARITY Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. {ECO 0000305}. # SMART SM00642 Aamy # SUBUNIT GLGB_ECOLI Monomer. # SUPFAM SSF51445 SSF51445 # SUPFAM SSF81296 SSF81296; 2 # TIGRFAMs TIGR01515 branching_enzym # eggNOG COG0296 LUCA # eggNOG ENOG4105C9C Bacteria BLAST swissprot:GLGB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLGB_ECOLI BioCyc ECOL316407:JW3395-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3395-MONOMER BioCyc EcoCyc:GLYCOGEN-BRANCH-MONOMER http://biocyc.org/getid?id=EcoCyc:GLYCOGEN-BRANCH-MONOMER BioCyc MetaCyc:GLYCOGEN-BRANCH-MONOMER http://biocyc.org/getid?id=MetaCyc:GLYCOGEN-BRANCH-MONOMER COG COG0296 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0296 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M205746200 http://dx.doi.org/10.1074/jbc.M205746200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.4.1.18 http://www.genome.jp/dbget-bin/www_bget?EC:2.4.1.18 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M13751 http://www.ebi.ac.uk/ena/data/view/M13751 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 2.4.1.18 http://enzyme.expasy.org/EC/2.4.1.18 EchoBASE EB0373 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0373 EcoGene EG10378 http://www.ecogene.org/geneInfo.php?eg_id=EG10378 EnsemblBacteria AAC76457 http://www.ensemblgenomes.org/id/AAC76457 EnsemblBacteria AAC76457 http://www.ensemblgenomes.org/id/AAC76457 EnsemblBacteria BAE77860 http://www.ensemblgenomes.org/id/BAE77860 EnsemblBacteria BAE77860 http://www.ensemblgenomes.org/id/BAE77860 EnsemblBacteria BAE77860 http://www.ensemblgenomes.org/id/BAE77860 EnsemblBacteria b3432 http://www.ensemblgenomes.org/id/b3432 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003844 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003844 GO_function GO:0004553 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004553 GO_function GO:0043169 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043169 GO_process GO:0005978 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005978 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 2.60.40.10 http://www.cathdb.info/version/latest/superfamily/2.60.40.10 Gene3D 2.60.40.1180 http://www.cathdb.info/version/latest/superfamily/2.60.40.1180 Gene3D 3.20.20.80 http://www.cathdb.info/version/latest/superfamily/3.20.20.80 GeneID 947940 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947940 HAMAP MF_00685 http://hamap.expasy.org/unirule/MF_00685 HOGENOM HOG000283037 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000283037&db=HOGENOM6 InParanoid P07762 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P07762 IntAct P07762 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P07762* IntEnz 2.4.1.18 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.1.18 InterPro IPR004193 http://www.ebi.ac.uk/interpro/entry/IPR004193 InterPro IPR006047 http://www.ebi.ac.uk/interpro/entry/IPR006047 InterPro IPR006048 http://www.ebi.ac.uk/interpro/entry/IPR006048 InterPro IPR006407 http://www.ebi.ac.uk/interpro/entry/IPR006407 InterPro IPR013780 http://www.ebi.ac.uk/interpro/entry/IPR013780 InterPro IPR013781 http://www.ebi.ac.uk/interpro/entry/IPR013781 InterPro IPR013783 http://www.ebi.ac.uk/interpro/entry/IPR013783 InterPro IPR014756 http://www.ebi.ac.uk/interpro/entry/IPR014756 InterPro IPR015902 http://www.ebi.ac.uk/interpro/entry/IPR015902 InterPro IPR017853 http://www.ebi.ac.uk/interpro/entry/IPR017853 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3395 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3395 KEGG_Gene eco:b3432 http://www.genome.jp/dbget-bin/www_bget?eco:b3432 KEGG_Orthology KO:K00700 http://www.genome.jp/dbget-bin/www_bget?KO:K00700 KEGG_Pathway ko00500 http://www.genome.jp/kegg-bin/show_pathway?ko00500 KEGG_Reaction rn:R02110 http://www.genome.jp/dbget-bin/www_bget?rn:R02110 OMA HFPSDDF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HFPSDDF PANTHER PTHR10357 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10357 PDB 1GTY http://www.ebi.ac.uk/pdbe-srv/view/entry/1GTY PDB 1M7X http://www.ebi.ac.uk/pdbe-srv/view/entry/1M7X PDB 4LPC http://www.ebi.ac.uk/pdbe-srv/view/entry/4LPC PDB 4LQ1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4LQ1 PDB 5E6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/5E6Y PDB 5E6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/5E6Z PDB 5E70 http://www.ebi.ac.uk/pdbe-srv/view/entry/5E70 PDBsum 1GTY http://www.ebi.ac.uk/pdbsum/1GTY PDBsum 1M7X http://www.ebi.ac.uk/pdbsum/1M7X PDBsum 4LPC http://www.ebi.ac.uk/pdbsum/4LPC PDBsum 4LQ1 http://www.ebi.ac.uk/pdbsum/4LQ1 PDBsum 5E6Y http://www.ebi.ac.uk/pdbsum/5E6Y PDBsum 5E6Z http://www.ebi.ac.uk/pdbsum/5E6Z PDBsum 5E70 http://www.ebi.ac.uk/pdbsum/5E70 PSORT swissprot:GLGB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLGB_ECOLI PSORT-B swissprot:GLGB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLGB_ECOLI PSORT2 swissprot:GLGB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLGB_ECOLI Pfam PF00128 http://pfam.xfam.org/family/PF00128 Pfam PF02806 http://pfam.xfam.org/family/PF02806 Pfam PF02922 http://pfam.xfam.org/family/PF02922 Phobius swissprot:GLGB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLGB_ECOLI PhylomeDB P07762 http://phylomedb.org/?seqid=P07762 ProteinModelPortal P07762 http://www.proteinmodelportal.org/query/uniprot/P07762 PubMed 12196524 http://www.ncbi.nlm.nih.gov/pubmed/12196524 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3013861 http://www.ncbi.nlm.nih.gov/pubmed/3013861 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417890 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417890 RefSeq WP_001283723 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001283723 SMART SM00642 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00642 SMR P07762 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P07762 STRING 511145.b3432 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3432&targetmode=cogs STRING COG0296 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0296&targetmode=cogs SUPFAM SSF51445 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51445 SUPFAM SSF81296 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81296 TIGRFAMs TIGR01515 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01515 UniProtKB GLGB_ECOLI http://www.uniprot.org/uniprot/GLGB_ECOLI UniProtKB-AC P07762 http://www.uniprot.org/uniprot/P07762 charge swissprot:GLGB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLGB_ECOLI eggNOG COG0296 http://eggnogapi.embl.de/nog_data/html/tree/COG0296 eggNOG ENOG4105C9C http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C9C epestfind swissprot:GLGB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLGB_ECOLI garnier swissprot:GLGB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLGB_ECOLI helixturnhelix swissprot:GLGB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLGB_ECOLI hmoment swissprot:GLGB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLGB_ECOLI iep swissprot:GLGB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLGB_ECOLI inforesidue swissprot:GLGB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLGB_ECOLI octanol swissprot:GLGB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLGB_ECOLI pepcoil swissprot:GLGB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLGB_ECOLI pepdigest swissprot:GLGB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLGB_ECOLI pepinfo swissprot:GLGB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLGB_ECOLI pepnet swissprot:GLGB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLGB_ECOLI pepstats swissprot:GLGB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLGB_ECOLI pepwheel swissprot:GLGB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLGB_ECOLI pepwindow swissprot:GLGB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLGB_ECOLI sigcleave swissprot:GLGB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLGB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260897 218 # EcoGene EG13903 ycgV # GO_component GO:0019867 outer membrane; IEA:InterPro. # GO_process GO:0043708 cell adhesion involved in biofilm formation; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0007155 cell adhesion # Gene3D 2.160.20.20 -; 1. # Gene3D 2.40.128.130 -; 1. # IntAct P76017 2 # InterPro IPR003991 Pertactin_virulence_factor # InterPro IPR004899 Pertactin_central # InterPro IPR005546 Autotransporte_beta # InterPro IPR006315 OM_autotransptr_brl # InterPro IPR011050 Pectin_lyase_fold/virulence # InterPro IPR012332 P22_tailspike_C-like # Organism YCGV_ECOLI Escherichia coli (strain K12) # PATRIC 32117654 VBIEscCol129921_1249 # PIR G64866 G64866 # PRINTS PR01484 PRTACTNFAMLY # PROSITE PS51208 AUTOTRANSPORTER # Pfam PF03212 Pertactin # Pfam PF03797 Autotransporter # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCGV_ECOLI Uncharacterized protein YcgV # RefSeq NP_415720 NC_000913.3 # RefSeq WP_001334788 NZ_LN832404.1 # SIMILARITY Contains 1 autotransporter (TC 1.B.12) domain. {ECO:0000255|PROSITE-ProRule PRU00556}. # SMART SM00869 Autotransporter # SUPFAM SSF103515 SSF103515 # SUPFAM SSF51126 SSF51126 # TCDB 1.B.12.2 the autotransporter-1 (at-1) family # TIGRFAMs TIGR01414 autotrans_barl # eggNOG COG3468 LUCA # eggNOG ENOG4105I1J Bacteria BLAST swissprot:YCGV_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCGV_ECOLI BioCyc ECOL316407:JW1193-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1193-MONOMER BioCyc EcoCyc:G6629-MONOMER http://biocyc.org/getid?id=EcoCyc:G6629-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3662 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3662 EcoGene EG13903 http://www.ecogene.org/geneInfo.php?eg_id=EG13903 EnsemblBacteria AAC74286 http://www.ensemblgenomes.org/id/AAC74286 EnsemblBacteria AAC74286 http://www.ensemblgenomes.org/id/AAC74286 EnsemblBacteria BAA36059 http://www.ensemblgenomes.org/id/BAA36059 EnsemblBacteria BAA36059 http://www.ensemblgenomes.org/id/BAA36059 EnsemblBacteria BAA36059 http://www.ensemblgenomes.org/id/BAA36059 EnsemblBacteria b1202 http://www.ensemblgenomes.org/id/b1202 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0019867 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019867 GO_process GO:0043708 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043708 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 Gene3D 2.160.20.20 http://www.cathdb.info/version/latest/superfamily/2.160.20.20 Gene3D 2.40.128.130 http://www.cathdb.info/version/latest/superfamily/2.40.128.130 GeneID 945767 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945767 HOGENOM HOG000009435 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009435&db=HOGENOM6 IntAct P76017 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76017* InterPro IPR003991 http://www.ebi.ac.uk/interpro/entry/IPR003991 InterPro IPR004899 http://www.ebi.ac.uk/interpro/entry/IPR004899 InterPro IPR005546 http://www.ebi.ac.uk/interpro/entry/IPR005546 InterPro IPR006315 http://www.ebi.ac.uk/interpro/entry/IPR006315 InterPro IPR011050 http://www.ebi.ac.uk/interpro/entry/IPR011050 InterPro IPR012332 http://www.ebi.ac.uk/interpro/entry/IPR012332 KEGG_Gene ecj:JW1193 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1193 KEGG_Gene eco:b1202 http://www.genome.jp/dbget-bin/www_bget?eco:b1202 OMA NFLNIGY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NFLNIGY PRINTS PR01484 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01484 PROSITE PS51208 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51208 PSORT swissprot:YCGV_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCGV_ECOLI PSORT-B swissprot:YCGV_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCGV_ECOLI PSORT2 swissprot:YCGV_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCGV_ECOLI Pfam PF03212 http://pfam.xfam.org/family/PF03212 Pfam PF03797 http://pfam.xfam.org/family/PF03797 Phobius swissprot:YCGV_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCGV_ECOLI PhylomeDB P76017 http://phylomedb.org/?seqid=P76017 ProteinModelPortal P76017 http://www.proteinmodelportal.org/query/uniprot/P76017 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415720 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415720 RefSeq WP_001334788 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001334788 SMART SM00869 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00869 STRING 511145.b1202 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1202&targetmode=cogs SUPFAM SSF103515 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103515 SUPFAM SSF51126 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51126 TCDB 1.B.12.2 http://www.tcdb.org/search/result.php?tc=1.B.12.2 TIGRFAMs TIGR01414 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01414 UniProtKB YCGV_ECOLI http://www.uniprot.org/uniprot/YCGV_ECOLI UniProtKB-AC P76017 http://www.uniprot.org/uniprot/P76017 charge swissprot:YCGV_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCGV_ECOLI eggNOG COG3468 http://eggnogapi.embl.de/nog_data/html/tree/COG3468 eggNOG ENOG4105I1J http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105I1J epestfind swissprot:YCGV_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCGV_ECOLI garnier swissprot:YCGV_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCGV_ECOLI helixturnhelix swissprot:YCGV_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCGV_ECOLI hmoment swissprot:YCGV_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCGV_ECOLI iep swissprot:YCGV_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCGV_ECOLI inforesidue swissprot:YCGV_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCGV_ECOLI octanol swissprot:YCGV_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCGV_ECOLI pepcoil swissprot:YCGV_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCGV_ECOLI pepdigest swissprot:YCGV_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCGV_ECOLI pepinfo swissprot:YCGV_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCGV_ECOLI pepnet swissprot:YCGV_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCGV_ECOLI pepstats swissprot:YCGV_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCGV_ECOLI pepwheel swissprot:YCGV_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCGV_ECOLI pepwindow swissprot:YCGV_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCGV_ECOLI sigcleave swissprot:YCGV_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCGV_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES XANQ_ECOLI Kinetic parameters KM=4.2 uM for xanthine {ECO 0000269|PubMed 16096267}; Vmax=6.36 nmol/min/mg enzyme {ECO 0000269|PubMed 16096267}; # BioGrid 4261448 20 # ENZYME REGULATION Inhibited by CCCP and N-ethylmaleimide. {ECO:0000269|PubMed 16096267}. # EcoGene EG13065 xanQ # FUNCTION XANQ_ECOLI Specific, proton motive force-dependent high-affinity transporter for xanthine. {ECO 0000269|PubMed 16096267}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_function GO:0042907 xanthine transmembrane transporter activity; IDA:EcoCyc. # GO_process GO:0042906 xanthine transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR006042 Xan_ur_permease # InterPro IPR006043 Xant/urac/vitC # KEGG_Brite ko02000 Transporters # Organism XANQ_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11119 PTHR11119 # PATRIC 32121174 VBIEscCol129921_2975 # PIR B65072 B65072 # PROSITE PS01116 XANTH_URACIL_PERMASE # Pfam PF00860 Xan_ur_permease # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName XANQ_ECOLI Xanthine permease XanQ # RefSeq NP_417358 NC_000913.3 # RefSeq WP_001280192 NZ_CP014272.1 # SEQUENCE CAUTION Sequence=AAA83063.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION XANQ_ECOLI Cell inner membrane {ECO 0000269|PubMed 16096267}; Multi-pass membrane protein {ECO 0000269|PubMed 16096267}. # TCDB 2.A.40.4:the nucleobase/ascorbate transporter (nat) or nucleobase cation symporter-2 (ncs2) family # TIGRFAMs TIGR00801 ncs2 # eggNOG COG2233 LUCA # eggNOG ENOG4105C2W Bacteria BLAST swissprot:XANQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:XANQ_ECOLI BioCyc ECOL316407:JW2850-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2850-MONOMER BioCyc EcoCyc:YGFO-MONOMER http://biocyc.org/getid?id=EcoCyc:YGFO-MONOMER BioCyc MetaCyc:YGFO-MONOMER http://biocyc.org/getid?id=MetaCyc:YGFO-MONOMER COG COG2233 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2233 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M109.030734 http://dx.doi.org/10.1074/jbc.M109.030734 DOI 10.1074/jbc.M800261200 http://dx.doi.org/10.1074/jbc.M800261200 DOI 10.1080/09687860500092927 http://dx.doi.org/10.1080/09687860500092927 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 EchoBASE EB2877 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2877 EcoGene EG13065 http://www.ecogene.org/geneInfo.php?eg_id=EG13065 EnsemblBacteria AAC75920 http://www.ensemblgenomes.org/id/AAC75920 EnsemblBacteria AAC75920 http://www.ensemblgenomes.org/id/AAC75920 EnsemblBacteria BAE76948 http://www.ensemblgenomes.org/id/BAE76948 EnsemblBacteria BAE76948 http://www.ensemblgenomes.org/id/BAE76948 EnsemblBacteria BAE76948 http://www.ensemblgenomes.org/id/BAE76948 EnsemblBacteria b2882 http://www.ensemblgenomes.org/id/b2882 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0042907 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042907 GO_process GO:0042906 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042906 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 949075 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949075 HOGENOM HOG000038198 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000038198&db=HOGENOM6 InParanoid P67444 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P67444 InterPro IPR006042 http://www.ebi.ac.uk/interpro/entry/IPR006042 InterPro IPR006043 http://www.ebi.ac.uk/interpro/entry/IPR006043 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2850 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2850 KEGG_Gene eco:b2882 http://www.genome.jp/dbget-bin/www_bget?eco:b2882 KEGG_Orthology KO:K16346 http://www.genome.jp/dbget-bin/www_bget?KO:K16346 OMA EGPAYLQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EGPAYLQ PANTHER PTHR11119 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11119 PROSITE PS01116 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01116 PSORT swissprot:XANQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:XANQ_ECOLI PSORT-B swissprot:XANQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:XANQ_ECOLI PSORT2 swissprot:XANQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:XANQ_ECOLI Pfam PF00860 http://pfam.xfam.org/family/PF00860 Phobius swissprot:XANQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:XANQ_ECOLI PhylomeDB P67444 http://phylomedb.org/?seqid=P67444 ProteinModelPortal P67444 http://www.proteinmodelportal.org/query/uniprot/P67444 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16096267 http://www.ncbi.nlm.nih.gov/pubmed/16096267 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18359771 http://www.ncbi.nlm.nih.gov/pubmed/18359771 PubMed 19581302 http://www.ncbi.nlm.nih.gov/pubmed/19581302 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417358 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417358 RefSeq WP_001280192 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001280192 STRING 511145.b2882 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2882&targetmode=cogs STRING COG2233 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2233&targetmode=cogs TCDB 2.A.40.4 http://www.tcdb.org/search/result.php?tc=2.A.40.4 TIGRFAMs TIGR00801 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00801 UniProtKB XANQ_ECOLI http://www.uniprot.org/uniprot/XANQ_ECOLI UniProtKB-AC P67444 http://www.uniprot.org/uniprot/P67444 charge swissprot:XANQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:XANQ_ECOLI eggNOG COG2233 http://eggnogapi.embl.de/nog_data/html/tree/COG2233 eggNOG ENOG4105C2W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C2W epestfind swissprot:XANQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:XANQ_ECOLI garnier swissprot:XANQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:XANQ_ECOLI helixturnhelix swissprot:XANQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:XANQ_ECOLI hmoment swissprot:XANQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:XANQ_ECOLI iep swissprot:XANQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:XANQ_ECOLI inforesidue swissprot:XANQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:XANQ_ECOLI octanol swissprot:XANQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:XANQ_ECOLI pepcoil swissprot:XANQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:XANQ_ECOLI pepdigest swissprot:XANQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:XANQ_ECOLI pepinfo swissprot:XANQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:XANQ_ECOLI pepnet swissprot:XANQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:XANQ_ECOLI pepstats swissprot:XANQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:XANQ_ECOLI pepwheel swissprot:XANQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:XANQ_ECOLI pepwindow swissprot:XANQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:XANQ_ECOLI sigcleave swissprot:XANQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:XANQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4261975 101 # EcoGene EG13937 rsxG # FUNCTION RSXG_ECOLI Part of a membrane complex involved in electron transport. Required to maintain the reduced state of SoxR. {ECO 0000255|HAMAP-Rule MF_00479, ECO 0000269|PubMed 12773378}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0009055 electron carrier activity; IEA:InterPro. # GO_function GO:0010181 FMN binding; IEA:InterPro. # GO_process GO:0022900 electron transport chain; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # HAMAP MF_00479 RsxG_RnfG # InterPro IPR007329 FMN-bd # InterPro IPR010209 Elect_transpt_RnfG/RsxG # Organism RSXG_ECOLI Escherichia coli (strain K12) # PATRIC 32118564 VBIEscCol129921_1702 # PIR A64920 A64920 # PIRSF PIRSF006091 E_trnsport_RnfG # Pfam PF04205 FMN_bind # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Electron transport complex subunit RsxG {ECO:0000255|HAMAP-Rule MF_00479} # RefSeq NP_416148 NC_000913.3 # RefSeq WP_000920784 NZ_LN832404.1 # SIMILARITY Belongs to the RnfG family. {ECO:0000255|HAMAP- Rule MF_00479}. # SMART SM00900 FMN_bind # SUBCELLULAR LOCATION RSXG_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_00479}. # SUBUNIT Composed of six subunits; RsxA, RsxB, RsxC, RsxD, RsxE and RsxG. {ECO:0000305|PubMed 12773378}. # TCDB 3.D.6.1:the putative ion (h(+) or na(+))-translocating nadh ferredoxin oxidoreductase (nfo or rnf) family # TIGRFAMs TIGR01947 rnfG # eggNOG COG4659 LUCA # eggNOG ENOG4108UQQ Bacteria BLAST swissprot:RSXG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RSXG_ECOLI BioCyc ECOL316407:JW1623-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1623-MONOMER BioCyc EcoCyc:G6875-MONOMER http://biocyc.org/getid?id=EcoCyc:G6875-MONOMER COG COG2869 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2869 DIP DIP-11722N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11722N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/emboj/cdg252 http://dx.doi.org/10.1093/emboj/cdg252 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3696 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3696 EcoGene EG13937 http://www.ecogene.org/geneInfo.php?eg_id=EG13937 EnsemblBacteria AAC74703 http://www.ensemblgenomes.org/id/AAC74703 EnsemblBacteria AAC74703 http://www.ensemblgenomes.org/id/AAC74703 EnsemblBacteria BAA15385 http://www.ensemblgenomes.org/id/BAA15385 EnsemblBacteria BAA15385 http://www.ensemblgenomes.org/id/BAA15385 EnsemblBacteria BAA15385 http://www.ensemblgenomes.org/id/BAA15385 EnsemblBacteria b1631 http://www.ensemblgenomes.org/id/b1631 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0010181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010181 GO_process GO:0022900 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022900 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GeneID 946158 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946158 HAMAP MF_00479 http://hamap.expasy.org/unirule/MF_00479 HOGENOM HOG000279312 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000279312&db=HOGENOM6 InParanoid P77285 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77285 IntAct P77285 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77285* InterPro IPR007329 http://www.ebi.ac.uk/interpro/entry/IPR007329 InterPro IPR010209 http://www.ebi.ac.uk/interpro/entry/IPR010209 KEGG_Gene ecj:JW1623 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1623 KEGG_Gene eco:b1631 http://www.genome.jp/dbget-bin/www_bget?eco:b1631 KEGG_Orthology KO:K03612 http://www.genome.jp/dbget-bin/www_bget?KO:K03612 OMA VMEATAP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VMEATAP PSORT swissprot:RSXG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RSXG_ECOLI PSORT-B swissprot:RSXG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RSXG_ECOLI PSORT2 swissprot:RSXG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RSXG_ECOLI Pfam PF04205 http://pfam.xfam.org/family/PF04205 Phobius swissprot:RSXG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RSXG_ECOLI PhylomeDB P77285 http://phylomedb.org/?seqid=P77285 ProteinModelPortal P77285 http://www.proteinmodelportal.org/query/uniprot/P77285 PubMed 12773378 http://www.ncbi.nlm.nih.gov/pubmed/12773378 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416148 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416148 RefSeq WP_000920784 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000920784 SMART SM00900 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00900 SMR P77285 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77285 STRING 511145.b1631 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1631&targetmode=cogs STRING COG2869 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2869&targetmode=cogs TCDB 3.D.6.1 http://www.tcdb.org/search/result.php?tc=3.D.6.1 TIGRFAMs TIGR01947 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01947 UniProtKB RSXG_ECOLI http://www.uniprot.org/uniprot/RSXG_ECOLI UniProtKB-AC P77285 http://www.uniprot.org/uniprot/P77285 charge swissprot:RSXG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RSXG_ECOLI eggNOG COG4659 http://eggnogapi.embl.de/nog_data/html/tree/COG4659 eggNOG ENOG4108UQQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UQQ epestfind swissprot:RSXG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RSXG_ECOLI garnier swissprot:RSXG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RSXG_ECOLI helixturnhelix swissprot:RSXG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RSXG_ECOLI hmoment swissprot:RSXG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RSXG_ECOLI iep swissprot:RSXG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RSXG_ECOLI inforesidue swissprot:RSXG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RSXG_ECOLI octanol swissprot:RSXG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RSXG_ECOLI pepcoil swissprot:RSXG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RSXG_ECOLI pepdigest swissprot:RSXG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RSXG_ECOLI pepinfo swissprot:RSXG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RSXG_ECOLI pepnet swissprot:RSXG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RSXG_ECOLI pepstats swissprot:RSXG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RSXG_ECOLI pepwheel swissprot:RSXG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RSXG_ECOLI pepwindow swissprot:RSXG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RSXG_ECOLI sigcleave swissprot:RSXG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RSXG_ECOLI ## Database ID URL or Descriptions # AltName KPPR_ECOLI Phosphopentokinase # BioGrid 4259590 20 # CATALYTIC ACTIVITY KPPR_ECOLI ATP + D-ribulose 5-phosphate = ADP + D- ribulose 1,5-bisphosphate. # EcoGene EG12365 prkB # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0004849 uridine kinase activity; IBA:GO_Central. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0008974 phosphoribulokinase activity; IEA:UniProtKB-EC. # GO_process GO:0005975 carbohydrate metabolic process; IEA:InterPro. # GO_process GO:0006206 pyrimidine nucleobase metabolic process; IBA:GO_Central. # GO_process GO:0043097 pyrimidine nucleoside salvage; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.300 -; 1. # IntAct P0AEX5 4 # InterPro IPR006082 PRK # InterPro IPR006083 PRK/URK # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00710 Carbon fixation in photosynthetic organisms # Organism KPPR_ECOLI Escherichia coli (strain K12) # PATRIC 32122144 VBIEscCol129921_3449 # PIR F65129 F65129 # PRINTS PR00478 PHRIBLKINASE # PROSITE PS00567 PHOSPHORIBULOKINASE # Pfam PF00485 PRK # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName KPPR_ECOLI Probable phosphoribulokinase # RefSeq NP_417814 NC_000913.3 # RefSeq WP_001274680 NZ_LN832404.1 # SIMILARITY Belongs to the phosphoribulokinase family. {ECO 0000305}. # SUPFAM SSF52540 SSF52540 # eggNOG COG3954 LUCA # eggNOG ENOG4105CJE Bacteria BLAST swissprot:KPPR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:KPPR_ECOLI BioCyc ECOL316407:JW3318-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3318-MONOMER BioCyc EcoCyc:EG12365-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12365-MONOMER COG COG0572 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0572 DIP DIP-10565N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10565N DOI 10.1016/0167-4781(91)90222-8 http://dx.doi.org/10.1016/0167-4781(91)90222-8 DOI 10.1016/0968-0004(94)90067-1 http://dx.doi.org/10.1016/0968-0004(94)90067-1 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/ng0694-205 http://dx.doi.org/10.1038/ng0694-205 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.19 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.19 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X61919 http://www.ebi.ac.uk/ena/data/view/X61919 ENZYME 2.7.1.19 http://enzyme.expasy.org/EC/2.7.1.19 EchoBASE EB2268 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2268 EcoGene EG12365 http://www.ecogene.org/geneInfo.php?eg_id=EG12365 EnsemblBacteria AAC76380 http://www.ensemblgenomes.org/id/AAC76380 EnsemblBacteria AAC76380 http://www.ensemblgenomes.org/id/AAC76380 EnsemblBacteria BAE77935 http://www.ensemblgenomes.org/id/BAE77935 EnsemblBacteria BAE77935 http://www.ensemblgenomes.org/id/BAE77935 EnsemblBacteria BAE77935 http://www.ensemblgenomes.org/id/BAE77935 EnsemblBacteria b3355 http://www.ensemblgenomes.org/id/b3355 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004849 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004849 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008974 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GO_process GO:0006206 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006206 GO_process GO:0043097 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043097 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947862 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947862 HOGENOM HOG000272991 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000272991&db=HOGENOM6 InParanoid P0AEX5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEX5 IntAct P0AEX5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEX5* IntEnz 2.7.1.19 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.19 InterPro IPR006082 http://www.ebi.ac.uk/interpro/entry/IPR006082 InterPro IPR006083 http://www.ebi.ac.uk/interpro/entry/IPR006083 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3318 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3318 KEGG_Gene eco:b3355 http://www.genome.jp/dbget-bin/www_bget?eco:b3355 KEGG_Orthology KO:K00855 http://www.genome.jp/dbget-bin/www_bget?KO:K00855 KEGG_Pathway ko00710 http://www.genome.jp/kegg-bin/show_pathway?ko00710 KEGG_Reaction rn:R01523 http://www.genome.jp/dbget-bin/www_bget?rn:R01523 MINT MINT-1286728 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1286728 OMA TDILFYE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TDILFYE PRINTS PR00478 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00478 PROSITE PS00567 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00567 PSORT swissprot:KPPR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:KPPR_ECOLI PSORT-B swissprot:KPPR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:KPPR_ECOLI PSORT2 swissprot:KPPR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:KPPR_ECOLI Pfam PF00485 http://pfam.xfam.org/family/PF00485 Phobius swissprot:KPPR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:KPPR_ECOLI ProteinModelPortal P0AEX5 http://www.proteinmodelportal.org/query/uniprot/P0AEX5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1756168 http://www.ncbi.nlm.nih.gov/pubmed/1756168 PubMed 7920643 http://www.ncbi.nlm.nih.gov/pubmed/7920643 PubMed 7940673 http://www.ncbi.nlm.nih.gov/pubmed/7940673 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417814 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417814 RefSeq WP_001274680 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001274680 SMR P0AEX5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEX5 STRING 511145.b3355 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3355&targetmode=cogs STRING COG0572 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0572&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB KPPR_ECOLI http://www.uniprot.org/uniprot/KPPR_ECOLI UniProtKB-AC P0AEX5 http://www.uniprot.org/uniprot/P0AEX5 charge swissprot:KPPR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:KPPR_ECOLI eggNOG COG3954 http://eggnogapi.embl.de/nog_data/html/tree/COG3954 eggNOG ENOG4105CJE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CJE epestfind swissprot:KPPR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:KPPR_ECOLI garnier swissprot:KPPR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:KPPR_ECOLI helixturnhelix swissprot:KPPR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:KPPR_ECOLI hmoment swissprot:KPPR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:KPPR_ECOLI iep swissprot:KPPR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:KPPR_ECOLI inforesidue swissprot:KPPR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:KPPR_ECOLI octanol swissprot:KPPR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:KPPR_ECOLI pepcoil swissprot:KPPR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:KPPR_ECOLI pepdigest swissprot:KPPR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:KPPR_ECOLI pepinfo swissprot:KPPR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:KPPR_ECOLI pepnet swissprot:KPPR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:KPPR_ECOLI pepstats swissprot:KPPR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:KPPR_ECOLI pepwheel swissprot:KPPR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:KPPR_ECOLI pepwindow swissprot:KPPR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:KPPR_ECOLI sigcleave swissprot:KPPR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:KPPR_ECOLI ## Database ID URL or Descriptions # AltName K(+)/H(+) antiporter {ECO:0000255|HAMAP-Rule MF_01412} # AltName KEFB_ECOLI NEM-activable K(+)/H(+) antiporter # BioGrid 4262061 11 # ENZYME REGULATION Activated by adducts between glutathione and electrophiles. {ECO:0000269|PubMed 9023177}. # EcoGene EG20110 kefB # FUNCTION KEFB_ECOLI Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. {ECO 0000255|HAMAP-Rule MF_01412, ECO 0000269|PubMed 3301813, ECO 0000269|PubMed 9023177}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IEA:UniProtKB-HAMAP. # GO_function GO:0015503 glutathione-regulated potassium exporter activity; IEA:UniProtKB-HAMAP. # GO_function KEFB_ECOLI GO 0015299 solute proton antiporter activity; IEA InterPro. # GO_process GO:0006813 potassium ion transport; IGI:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # Gene3D 3.40.50.720 -; 1. # HAMAP MF_01412 K_H_efflux_KefB # InterPro IPR003148 RCK_N # InterPro IPR004771 K/H_exchanger # InterPro IPR006153 Cation/H_exchanger # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR020884 K_H_efflux_KefB # Organism KEFB_ECOLI Escherichia coli (strain K12) # PATRIC 32122134 VBIEscCol129921_3444 # PIR A65129 A65129 # PROSITE PS51201 RCK_N # Pfam PF00999 Na_H_Exchanger # Pfam PF02254 TrkA_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Glutathione-regulated potassium-efflux system protein KefB {ECO:0000255|HAMAP-Rule MF_01412} # RefSeq NP_417809 NC_000913.3 # RefSeq WP_000399147 NZ_LN832404.1 # SIMILARITY Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. KefB subfamily. {ECO 0000255|HAMAP-Rule:MF_01412}. # SIMILARITY Contains 1 RCK N-terminal domain. {ECO:0000255|HAMAP- Rule MF_01412}. # SUBCELLULAR LOCATION KEFB_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01412, ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255|HAMAP-Rule MF_01412, ECO 0000269|PubMed 15919996}. # SUBUNIT Interacts with the regulatory subunit KefG. {ECO:0000255|HAMAP-Rule MF_01412}. # SUPFAM SSF51735 SSF51735 # TCDB 2.A.37.1:the monovalent cation proton antiporter-2 (cpa2) family # TIGRFAMs TIGR00932 2a37 # eggNOG COG0475 LUCA # eggNOG COG1226 LUCA # eggNOG ENOG4105CKD Bacteria BLAST swissprot:KEFB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:KEFB_ECOLI BioCyc ECOL316407:JW3313-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3313-MONOMER BioCyc EcoCyc:KEFB-MONOMER http://biocyc.org/getid?id=EcoCyc:KEFB-MONOMER BioCyc MetaCyc:KEFB-MONOMER http://biocyc.org/getid?id=MetaCyc:KEFB-MONOMER COG COG0475 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0475 COG COG1226 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1226 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB4144 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4144 EcoGene EG20110 http://www.ecogene.org/geneInfo.php?eg_id=EG20110 EnsemblBacteria AAC76375 http://www.ensemblgenomes.org/id/AAC76375 EnsemblBacteria AAC76375 http://www.ensemblgenomes.org/id/AAC76375 EnsemblBacteria BAE77940 http://www.ensemblgenomes.org/id/BAE77940 EnsemblBacteria BAE77940 http://www.ensemblgenomes.org/id/BAE77940 EnsemblBacteria BAE77940 http://www.ensemblgenomes.org/id/BAE77940 EnsemblBacteria b3350 http://www.ensemblgenomes.org/id/b3350 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015299 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015299 GO_function GO:0015503 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015503 GO_process GO:0006813 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 947858 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947858 HAMAP MF_01412 http://hamap.expasy.org/unirule/MF_01412 HOGENOM HOG000179076 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000179076&db=HOGENOM6 InParanoid P45522 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45522 InterPro IPR003148 http://www.ebi.ac.uk/interpro/entry/IPR003148 InterPro IPR004771 http://www.ebi.ac.uk/interpro/entry/IPR004771 InterPro IPR006153 http://www.ebi.ac.uk/interpro/entry/IPR006153 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR020884 http://www.ebi.ac.uk/interpro/entry/IPR020884 KEGG_Gene ecj:JW3313 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3313 KEGG_Gene eco:b3350 http://www.genome.jp/dbget-bin/www_bget?eco:b3350 KEGG_Orthology KO:K11747 http://www.genome.jp/dbget-bin/www_bget?KO:K11747 OMA RELMPVH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RELMPVH PROSITE PS51201 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51201 PSORT swissprot:KEFB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:KEFB_ECOLI PSORT-B swissprot:KEFB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:KEFB_ECOLI PSORT2 swissprot:KEFB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:KEFB_ECOLI Pfam PF00999 http://pfam.xfam.org/family/PF00999 Pfam PF02254 http://pfam.xfam.org/family/PF02254 Phobius swissprot:KEFB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:KEFB_ECOLI PhylomeDB P45522 http://phylomedb.org/?seqid=P45522 ProteinModelPortal P45522 http://www.proteinmodelportal.org/query/uniprot/P45522 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3301813 http://www.ncbi.nlm.nih.gov/pubmed/3301813 PubMed 9023177 http://www.ncbi.nlm.nih.gov/pubmed/9023177 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417809 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417809 RefSeq WP_000399147 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000399147 SMR P45522 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45522 STRING 511145.b3350 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3350&targetmode=cogs STRING COG0475 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0475&targetmode=cogs STRING COG1226 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1226&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 TCDB 2.A.37.1 http://www.tcdb.org/search/result.php?tc=2.A.37.1 TIGRFAMs TIGR00932 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00932 UniProtKB KEFB_ECOLI http://www.uniprot.org/uniprot/KEFB_ECOLI UniProtKB-AC P45522 http://www.uniprot.org/uniprot/P45522 charge swissprot:KEFB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:KEFB_ECOLI eggNOG COG0475 http://eggnogapi.embl.de/nog_data/html/tree/COG0475 eggNOG COG1226 http://eggnogapi.embl.de/nog_data/html/tree/COG1226 eggNOG ENOG4105CKD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CKD epestfind swissprot:KEFB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:KEFB_ECOLI garnier swissprot:KEFB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:KEFB_ECOLI helixturnhelix swissprot:KEFB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:KEFB_ECOLI hmoment swissprot:KEFB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:KEFB_ECOLI iep swissprot:KEFB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:KEFB_ECOLI inforesidue swissprot:KEFB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:KEFB_ECOLI octanol swissprot:KEFB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:KEFB_ECOLI pepcoil swissprot:KEFB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:KEFB_ECOLI pepdigest swissprot:KEFB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:KEFB_ECOLI pepinfo swissprot:KEFB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:KEFB_ECOLI pepnet swissprot:KEFB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:KEFB_ECOLI pepstats swissprot:KEFB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:KEFB_ECOLI pepwheel swissprot:KEFB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:KEFB_ECOLI pepwindow swissprot:KEFB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:KEFB_ECOLI sigcleave swissprot:KEFB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:KEFB_ECOLI ## Database ID URL or Descriptions # AltName TNPA_ECOLI Transposon Tn1000 transposase # FUNCTION TNPA_ECOLI Required for transposition of transposon Tn1000. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # InterPro IPR002513 Tn3_Tnp_DDE_dom # InterPro IPR025296 DUF4158 # Organism TNPA_ECOLI Escherichia coli (strain K12) # PIR I56963 I56963 # Pfam PF01526 DDE_Tnp_Tn3 # Pfam PF13700 DUF4158 # RecName TNPA_ECOLI Transposase for transposon gamma-delta # RefSeq NP_061389 NC_002483.1 # RefSeq WP_001143750 NZ_CP014273.1 # SIMILARITY Belongs to the transposase 7 family. {ECO 0000305}. # eggNOG COG4644 LUCA # eggNOG ENOG4105D13 Bacteria BLAST swissprot:TNPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TNPA_ECOLI BioCyc ECOL316385:GJ8B-1334-MONOMER http://biocyc.org/getid?id=ECOL316385:GJ8B-1334-MONOMER DOI 10.1093/nar/19.8.1845 http://dx.doi.org/10.1093/nar/19.8.1845 DOI 10.1266/jjg.69.269 http://dx.doi.org/10.1266/jjg.69.269 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL D16449 http://www.ebi.ac.uk/ena/data/view/D16449 EMBL X56780 http://www.ebi.ac.uk/ena/data/view/X56780 EMBL X60200 http://www.ebi.ac.uk/ena/data/view/X60200 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GeneID 1263527 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263527 HOGENOM HOG000221546 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000221546&db=HOGENOM6 InterPro IPR002513 http://www.ebi.ac.uk/interpro/entry/IPR002513 InterPro IPR025296 http://www.ebi.ac.uk/interpro/entry/IPR025296 OMA HINFLGR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HINFLGR PSORT swissprot:TNPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TNPA_ECOLI PSORT-B swissprot:TNPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TNPA_ECOLI PSORT2 swissprot:TNPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TNPA_ECOLI Pfam PF01526 http://pfam.xfam.org/family/PF01526 Pfam PF13700 http://pfam.xfam.org/family/PF13700 Phobius swissprot:TNPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TNPA_ECOLI ProteinModelPortal Q00037 http://www.proteinmodelportal.org/query/uniprot/Q00037 PubMed 1709493 http://www.ncbi.nlm.nih.gov/pubmed/1709493 PubMed 7612932 http://www.ncbi.nlm.nih.gov/pubmed/7612932 PubMed 8080658 http://www.ncbi.nlm.nih.gov/pubmed/8080658 RefSeq NP_061389 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061389 RefSeq WP_001143750 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001143750 SMR Q00037 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q00037 STRING 316385.ECDH10B_1364 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316385.ECDH10B_1364&targetmode=cogs UniProtKB TNPA_ECOLI http://www.uniprot.org/uniprot/TNPA_ECOLI UniProtKB-AC Q00037 http://www.uniprot.org/uniprot/Q00037 charge swissprot:TNPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TNPA_ECOLI eggNOG COG4644 http://eggnogapi.embl.de/nog_data/html/tree/COG4644 eggNOG ENOG4105D13 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D13 epestfind swissprot:TNPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TNPA_ECOLI garnier swissprot:TNPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TNPA_ECOLI helixturnhelix swissprot:TNPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TNPA_ECOLI hmoment swissprot:TNPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TNPA_ECOLI iep swissprot:TNPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TNPA_ECOLI inforesidue swissprot:TNPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TNPA_ECOLI octanol swissprot:TNPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TNPA_ECOLI pepcoil swissprot:TNPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TNPA_ECOLI pepdigest swissprot:TNPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TNPA_ECOLI pepinfo swissprot:TNPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TNPA_ECOLI pepnet swissprot:TNPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TNPA_ECOLI pepstats swissprot:TNPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TNPA_ECOLI pepwheel swissprot:TNPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TNPA_ECOLI pepwindow swissprot:TNPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TNPA_ECOLI sigcleave swissprot:TNPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TNPA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260437 107 # DISRUPTION PHENOTYPE Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain. {ECO:0000269|PubMed 20345943}. # EcoGene EG11990 yehD # FUNCTION YEHD_ECOLI Part of the yehABCD fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. {ECO 0000269|PubMed 20345943}. # GO_component GO:0009289 pilus; IDA:EcoCyc. # GO_process GO:0007155 cell adhesion; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0007155 cell adhesion # Gene3D 2.60.40.1090 -; 1. # INDUCTION Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression. {ECO:0000269|PubMed 20345943}. # IntAct P33343 3 # InterPro IPR000259 Adhesion_dom_fimbrial # InterPro IPR008966 Adhesion_dom # MISCELLANEOUS The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed. {ECO:0000305|PubMed 20345943}. # Organism YEHD_ECOLI Escherichia coli (strain K12) # PATRIC 32119555 VBIEscCol129921_2188 # PIR F64978 F64978 # Pfam PF00419 Fimbrial # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEHD_ECOLI Uncharacterized fimbrial-like protein YehD # RefSeq NP_416614 NC_000913.3 # RefSeq WP_000830456 NZ_LN832404.1 # SIMILARITY Belongs to the fimbrial protein family. {ECO 0000305}. # SUPFAM SSF49401 SSF49401 # eggNOG ENOG41063W2 Bacteria # eggNOG ENOG41122IH LUCA BLAST swissprot:YEHD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEHD_ECOLI BioCyc ECOL316407:JW2098-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2098-MONOMER BioCyc EcoCyc:EG11990-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11990-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1462-2920.2010.02202.x http://dx.doi.org/10.1111/j.1462-2920.2010.02202.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1933 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1933 EcoGene EG11990 http://www.ecogene.org/geneInfo.php?eg_id=EG11990 EnsemblBacteria AAC75172 http://www.ensemblgenomes.org/id/AAC75172 EnsemblBacteria AAC75172 http://www.ensemblgenomes.org/id/AAC75172 EnsemblBacteria BAE76589 http://www.ensemblgenomes.org/id/BAE76589 EnsemblBacteria BAE76589 http://www.ensemblgenomes.org/id/BAE76589 EnsemblBacteria BAE76589 http://www.ensemblgenomes.org/id/BAE76589 EnsemblBacteria b2111 http://www.ensemblgenomes.org/id/b2111 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009289 GO_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 Gene3D 2.60.40.1090 http://www.cathdb.info/version/latest/superfamily/2.60.40.1090 GeneID 946619 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946619 HOGENOM HOG000009509 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009509&db=HOGENOM6 IntAct P33343 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33343* InterPro IPR000259 http://www.ebi.ac.uk/interpro/entry/IPR000259 InterPro IPR008966 http://www.ebi.ac.uk/interpro/entry/IPR008966 KEGG_Gene ecj:JW2098 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2098 KEGG_Gene eco:b2111 http://www.genome.jp/dbget-bin/www_bget?eco:b2111 OMA KCTNTAN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KCTNTAN PSORT swissprot:YEHD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEHD_ECOLI PSORT-B swissprot:YEHD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEHD_ECOLI PSORT2 swissprot:YEHD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEHD_ECOLI Pfam PF00419 http://pfam.xfam.org/family/PF00419 Phobius swissprot:YEHD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEHD_ECOLI ProteinModelPortal P33343 http://www.proteinmodelportal.org/query/uniprot/P33343 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20345943 http://www.ncbi.nlm.nih.gov/pubmed/20345943 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416614 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416614 RefSeq WP_000830456 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000830456 STRING 511145.b2111 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2111&targetmode=cogs SUPFAM SSF49401 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49401 UniProtKB YEHD_ECOLI http://www.uniprot.org/uniprot/YEHD_ECOLI UniProtKB-AC P33343 http://www.uniprot.org/uniprot/P33343 charge swissprot:YEHD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEHD_ECOLI eggNOG ENOG41063W2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41063W2 eggNOG ENOG41122IH http://eggnogapi.embl.de/nog_data/html/tree/ENOG41122IH epestfind swissprot:YEHD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEHD_ECOLI garnier swissprot:YEHD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEHD_ECOLI helixturnhelix swissprot:YEHD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEHD_ECOLI hmoment swissprot:YEHD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEHD_ECOLI iep swissprot:YEHD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEHD_ECOLI inforesidue swissprot:YEHD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEHD_ECOLI octanol swissprot:YEHD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEHD_ECOLI pepcoil swissprot:YEHD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEHD_ECOLI pepdigest swissprot:YEHD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEHD_ECOLI pepinfo swissprot:YEHD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEHD_ECOLI pepnet swissprot:YEHD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEHD_ECOLI pepstats swissprot:YEHD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEHD_ECOLI pepwheel swissprot:YEHD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEHD_ECOLI pepwindow swissprot:YEHD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEHD_ECOLI sigcleave swissprot:YEHD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEHD_ECOLI ## Database ID URL or Descriptions # AltName SYM_ECOLI Methionyl-tRNA synthetase # BRENDA 6.1.1.10 2026 # CATALYTIC ACTIVITY SYM_ECOLI ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met). # CDD cd00814 MetRS_core # CDD cd02800 tRNA_bind_EcMetRS_like # COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI 29105; Note=Binds 1 zinc ion per subunit.; # EcoGene EG10586 metG # FUNCTION SYM_ECOLI Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0000049 tRNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0004825 methionine-tRNA ligase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_process GO:0006431 methionyl-tRNA aminoacylation; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0006520 cellular amino acid metabolic process # Gene3D 1.10.730.10 -; 1. # Gene3D 2.20.28.20 -; 1. # Gene3D 3.40.50.620 -; 2. # HAMAP MF_00098 Met_tRNA_synth_type1 # INTERACTION SYM_ECOLI P60422 rplB; NbExp=2; IntAct=EBI-909268, EBI-543515; # IntAct P00959 3 # InterPro IPR001412 aa-tRNA-synth_I_CS # InterPro IPR002547 tRNA-bd_dom # InterPro IPR004495 Met-tRNA-synth_bsu_C # InterPro IPR009080 tRNAsynth_Ia_anticodon-bd # InterPro IPR012340 NA-bd_OB-fold # InterPro IPR014729 Rossmann-like_a/b/a_fold # InterPro IPR014758 Met-tRNA_synth # InterPro IPR015413 Methionyl/Leucyl_tRNA_Synth # InterPro IPR023458 Met-tRNA_ligase_1 # InterPro IPR029038 MetRS_Zn # InterPro IPR033911 MetRS_core # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01007 Amino acid related enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # KEGG_Pathway ko00450 Selenocompound metabolism # KEGG_Pathway ko00970 Aminoacyl-tRNA biosynthesis # Organism SYM_ECOLI Escherichia coli (strain K12) # PATRIC 32119561 VBIEscCol129921_2191 # PDB 1F4L X-ray; 1.85 A; A=1-551 # PDB 1MEA NMR; -; A=139-164 # PDB 1MED NMR; -; A=139-164 # PDB 1P7P X-ray; 1.80 A; A=2-552 # PDB 1PFU X-ray; 1.91 A; A=2-552 # PDB 1PFV X-ray; 1.70 A; A=2-552 # PDB 1PFW X-ray; 1.78 A; A=2-552 # PDB 1PFY X-ray; 1.93 A; A=2-552 # PDB 1PG0 X-ray; 1.90 A; A=2-552 # PDB 1PG2 X-ray; 1.75 A; A=2-552 # PDB 1QQT X-ray; 2.03 A; A=2-552 # PDB 3H97 X-ray; 1.70 A; A=1-548 # PDB 3H99 X-ray; 1.40 A; A=1-548 # PDB 3H9B X-ray; 1.50 A; A=1-548 # PDB 3H9C X-ray; 1.40 A; A=2-548 # PIR S14427 SYECMT # PRINTS PR01041 TRNASYNTHMET # PROSITE PS00178 AA_TRNA_LIGASE_I # PROSITE PS50886 TRBD # Pfam PF01588 tRNA_bind # Pfam PF09334 tRNA-synt_1g # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SYM_ECOLI Methionine--tRNA ligase # RefSeq NP_416617 NC_000913.3 # RefSeq WP_001350533 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA60526.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily. {ECO 0000305}. # SIMILARITY Contains 1 tRNA-binding domain. {ECO 0000305}. # SUBCELLULAR LOCATION SYM_ECOLI Cytoplasm. # SUBUNIT Homodimer. {ECO:0000269|PubMed 11243794}. # SUPFAM SSF47323 SSF47323 # SUPFAM SSF50249 SSF50249 # SUPFAM SSF57770 SSF57770 # TIGRFAMs TIGR00398 metG # TIGRFAMs TIGR00399 metG_C_term # eggNOG COG0073 LUCA # eggNOG COG0143 LUCA # eggNOG ENOG4105CKH Bacteria BLAST swissprot:SYM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SYM_ECOLI BioCyc ECOL316407:JW2101-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2101-MONOMER BioCyc EcoCyc:METG-MONOMER http://biocyc.org/getid?id=EcoCyc:METG-MONOMER BioCyc MetaCyc:METG-MONOMER http://biocyc.org/getid?id=MetaCyc:METG-MONOMER COG COG0143 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0143 DIP DIP-10194N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10194N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/jmbi.1993.1352 http://dx.doi.org/10.1006/jmbi.1993.1352 DOI 10.1006/jmbi.1993.1353 http://dx.doi.org/10.1006/jmbi.1993.1353 DOI 10.1006/jmbi.1999.3339 http://dx.doi.org/10.1006/jmbi.1999.3339 DOI 10.1006/jmbi.2001.4408 http://dx.doi.org/10.1006/jmbi.2001.4408 DOI 10.1007/BF00315804 http://dx.doi.org/10.1007/BF00315804 DOI 10.1016/0014-5793(91)80879-8 http://dx.doi.org/10.1016/0014-5793(91)80879-8 DOI 10.1016/0022-2836(82)90492-2 http://dx.doi.org/10.1016/0022-2836(82)90492-2 DOI 10.1016/0300-9084(90)90126-2 http://dx.doi.org/10.1016/0300-9084(90)90126-2 DOI 10.1016/S0022-2836(05)80331-6 http://dx.doi.org/10.1016/S0022-2836(05)80331-6 DOI 10.1021/bi00487a029 http://dx.doi.org/10.1021/bi00487a029 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.1.1.10 http://www.genome.jp/dbget-bin/www_bget?EC:6.1.1.10 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K02671 http://www.ebi.ac.uk/ena/data/view/K02671 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X55791 http://www.ebi.ac.uk/ena/data/view/X55791 ENZYME 6.1.1.10 http://enzyme.expasy.org/EC/6.1.1.10 EchoBASE EB0581 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0581 EcoGene EG10586 http://www.ecogene.org/geneInfo.php?eg_id=EG10586 EnsemblBacteria AAC75175 http://www.ensemblgenomes.org/id/AAC75175 EnsemblBacteria AAC75175 http://www.ensemblgenomes.org/id/AAC75175 EnsemblBacteria BAE76592 http://www.ensemblgenomes.org/id/BAE76592 EnsemblBacteria BAE76592 http://www.ensemblgenomes.org/id/BAE76592 EnsemblBacteria BAE76592 http://www.ensemblgenomes.org/id/BAE76592 EnsemblBacteria b2114 http://www.ensemblgenomes.org/id/b2114 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0000049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000049 GO_function GO:0004825 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004825 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_process GO:0006431 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006431 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 Gene3D 1.10.730.10 http://www.cathdb.info/version/latest/superfamily/1.10.730.10 Gene3D 2.20.28.20 http://www.cathdb.info/version/latest/superfamily/2.20.28.20 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 GeneID 946643 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946643 HAMAP MF_00098 http://hamap.expasy.org/unirule/MF_00098 HOGENOM HOG000200400 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000200400&db=HOGENOM6 InParanoid P00959 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00959 IntAct P00959 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00959* IntEnz 6.1.1.10 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.1.1.10 InterPro IPR001412 http://www.ebi.ac.uk/interpro/entry/IPR001412 InterPro IPR002547 http://www.ebi.ac.uk/interpro/entry/IPR002547 InterPro IPR004495 http://www.ebi.ac.uk/interpro/entry/IPR004495 InterPro IPR009080 http://www.ebi.ac.uk/interpro/entry/IPR009080 InterPro IPR012340 http://www.ebi.ac.uk/interpro/entry/IPR012340 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 InterPro IPR014758 http://www.ebi.ac.uk/interpro/entry/IPR014758 InterPro IPR015413 http://www.ebi.ac.uk/interpro/entry/IPR015413 InterPro IPR023458 http://www.ebi.ac.uk/interpro/entry/IPR023458 InterPro IPR029038 http://www.ebi.ac.uk/interpro/entry/IPR029038 InterPro IPR033911 http://www.ebi.ac.uk/interpro/entry/IPR033911 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW2101 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2101 KEGG_Gene eco:b2114 http://www.genome.jp/dbget-bin/www_bget?eco:b2114 KEGG_Orthology KO:K01874 http://www.genome.jp/dbget-bin/www_bget?KO:K01874 KEGG_Pathway ko00450 http://www.genome.jp/kegg-bin/show_pathway?ko00450 KEGG_Pathway ko00970 http://www.genome.jp/kegg-bin/show_pathway?ko00970 KEGG_Reaction rn:R03659 http://www.genome.jp/dbget-bin/www_bget?rn:R03659 KEGG_Reaction rn:R04773 http://www.genome.jp/dbget-bin/www_bget?rn:R04773 OMA FWPAMLD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FWPAMLD PDB 1F4L http://www.ebi.ac.uk/pdbe-srv/view/entry/1F4L PDB 1MEA http://www.ebi.ac.uk/pdbe-srv/view/entry/1MEA PDB 1MED http://www.ebi.ac.uk/pdbe-srv/view/entry/1MED PDB 1P7P http://www.ebi.ac.uk/pdbe-srv/view/entry/1P7P PDB 1PFU http://www.ebi.ac.uk/pdbe-srv/view/entry/1PFU PDB 1PFV http://www.ebi.ac.uk/pdbe-srv/view/entry/1PFV PDB 1PFW http://www.ebi.ac.uk/pdbe-srv/view/entry/1PFW PDB 1PFY http://www.ebi.ac.uk/pdbe-srv/view/entry/1PFY PDB 1PG0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1PG0 PDB 1PG2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1PG2 PDB 1QQT http://www.ebi.ac.uk/pdbe-srv/view/entry/1QQT PDB 3H97 http://www.ebi.ac.uk/pdbe-srv/view/entry/3H97 PDB 3H99 http://www.ebi.ac.uk/pdbe-srv/view/entry/3H99 PDB 3H9B http://www.ebi.ac.uk/pdbe-srv/view/entry/3H9B PDB 3H9C http://www.ebi.ac.uk/pdbe-srv/view/entry/3H9C PDBsum 1F4L http://www.ebi.ac.uk/pdbsum/1F4L PDBsum 1MEA http://www.ebi.ac.uk/pdbsum/1MEA PDBsum 1MED http://www.ebi.ac.uk/pdbsum/1MED PDBsum 1P7P http://www.ebi.ac.uk/pdbsum/1P7P PDBsum 1PFU http://www.ebi.ac.uk/pdbsum/1PFU PDBsum 1PFV http://www.ebi.ac.uk/pdbsum/1PFV PDBsum 1PFW http://www.ebi.ac.uk/pdbsum/1PFW PDBsum 1PFY http://www.ebi.ac.uk/pdbsum/1PFY PDBsum 1PG0 http://www.ebi.ac.uk/pdbsum/1PG0 PDBsum 1PG2 http://www.ebi.ac.uk/pdbsum/1PG2 PDBsum 1QQT http://www.ebi.ac.uk/pdbsum/1QQT PDBsum 3H97 http://www.ebi.ac.uk/pdbsum/3H97 PDBsum 3H99 http://www.ebi.ac.uk/pdbsum/3H99 PDBsum 3H9B http://www.ebi.ac.uk/pdbsum/3H9B PDBsum 3H9C http://www.ebi.ac.uk/pdbsum/3H9C PRINTS PR01041 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01041 PROSITE PS00178 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00178 PROSITE PS50886 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50886 PSORT swissprot:SYM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SYM_ECOLI PSORT-B swissprot:SYM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SYM_ECOLI PSORT2 swissprot:SYM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SYM_ECOLI Pfam PF01588 http://pfam.xfam.org/family/PF01588 Pfam PF09334 http://pfam.xfam.org/family/PF09334 Phobius swissprot:SYM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SYM_ECOLI PhylomeDB P00959 http://phylomedb.org/?seqid=P00959 ProteinModelPortal P00959 http://www.proteinmodelportal.org/query/uniprot/P00959 PubMed 10600385 http://www.ncbi.nlm.nih.gov/pubmed/10600385 PubMed 11243794 http://www.ncbi.nlm.nih.gov/pubmed/11243794 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1702021 http://www.ncbi.nlm.nih.gov/pubmed/1702021 PubMed 1959615 http://www.ncbi.nlm.nih.gov/pubmed/1959615 PubMed 2126467 http://www.ncbi.nlm.nih.gov/pubmed/2126467 PubMed 2254937 http://www.ncbi.nlm.nih.gov/pubmed/2254937 PubMed 2259334 http://www.ncbi.nlm.nih.gov/pubmed/2259334 PubMed 6094501 http://www.ncbi.nlm.nih.gov/pubmed/6094501 PubMed 6756915 http://www.ncbi.nlm.nih.gov/pubmed/6756915 PubMed 7042987 http://www.ncbi.nlm.nih.gov/pubmed/7042987 PubMed 8515465 http://www.ncbi.nlm.nih.gov/pubmed/8515465 PubMed 8515466 http://www.ncbi.nlm.nih.gov/pubmed/8515466 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_416617 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416617 RefSeq WP_001350533 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001350533 SMR P00959 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00959 STRING 511145.b2114 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2114&targetmode=cogs STRING COG0143 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0143&targetmode=cogs SUPFAM SSF47323 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47323 SUPFAM SSF50249 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50249 SUPFAM SSF57770 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF57770 SWISS-2DPAGE P00959 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P00959 TIGRFAMs TIGR00398 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00398 TIGRFAMs TIGR00399 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00399 UniProtKB SYM_ECOLI http://www.uniprot.org/uniprot/SYM_ECOLI UniProtKB-AC P00959 http://www.uniprot.org/uniprot/P00959 charge swissprot:SYM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SYM_ECOLI eggNOG COG0073 http://eggnogapi.embl.de/nog_data/html/tree/COG0073 eggNOG COG0143 http://eggnogapi.embl.de/nog_data/html/tree/COG0143 eggNOG ENOG4105CKH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CKH epestfind swissprot:SYM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SYM_ECOLI garnier swissprot:SYM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SYM_ECOLI helixturnhelix swissprot:SYM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SYM_ECOLI hmoment swissprot:SYM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SYM_ECOLI iep swissprot:SYM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SYM_ECOLI inforesidue swissprot:SYM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SYM_ECOLI octanol swissprot:SYM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SYM_ECOLI pepcoil swissprot:SYM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SYM_ECOLI pepdigest swissprot:SYM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SYM_ECOLI pepinfo swissprot:SYM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SYM_ECOLI pepnet swissprot:SYM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SYM_ECOLI pepstats swissprot:SYM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SYM_ECOLI pepwheel swissprot:SYM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SYM_ECOLI pepwindow swissprot:SYM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SYM_ECOLI sigcleave swissprot:SYM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SYM_ECOLI ## Database ID URL or Descriptions # BioGrid 4261239 25 # EcoGene EG14159 yfeR # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000986 bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; ISS:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # IntAct P0ACR7 2 # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR005119 LysR_subst-bd # InterPro IPR011991 WHTH_DNA-bd_dom # Organism YFER_ECOLI Escherichia coli (strain K12) # PATRIC 32120199 VBIEscCol129921_2502 # PIR H65014 H65014 # PRINTS PR00039 HTHLYSR # PROSITE PS50931 HTH_LYSR # Pfam PF00126 HTH_1 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFER_ECOLI Uncharacterized HTH-type transcriptional regulator YfeR # RefSeq NP_416904 NC_000913.3 # RefSeq WP_001109794 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lysR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00253}. # SUPFAM SSF46785 SSF46785 # eggNOG ENOG4108M0I Bacteria # eggNOG ENOG410XQRQ LUCA BLAST swissprot:YFER_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFER_ECOLI BioCyc ECOL316407:JW2400-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2400-MONOMER BioCyc EcoCyc:G7257-MONOMER http://biocyc.org/getid?id=EcoCyc:G7257-MONOMER DIP DIP-12017N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12017N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3911 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3911 EcoGene EG14159 http://www.ecogene.org/geneInfo.php?eg_id=EG14159 EnsemblBacteria AAC75462 http://www.ensemblgenomes.org/id/AAC75462 EnsemblBacteria AAC75462 http://www.ensemblgenomes.org/id/AAC75462 EnsemblBacteria BAA16280 http://www.ensemblgenomes.org/id/BAA16280 EnsemblBacteria BAA16280 http://www.ensemblgenomes.org/id/BAA16280 EnsemblBacteria BAA16280 http://www.ensemblgenomes.org/id/BAA16280 EnsemblBacteria b2409 http://www.ensemblgenomes.org/id/b2409 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000986 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000986 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 946873 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946873 HOGENOM HOG000233514 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000233514&db=HOGENOM6 InParanoid P0ACR7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACR7 IntAct P0ACR7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACR7* InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW2400 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2400 KEGG_Gene eco:b2409 http://www.genome.jp/dbget-bin/www_bget?eco:b2409 OMA IHRRDDK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IHRRDDK PRINTS PR00039 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00039 PROSITE PS50931 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50931 PSORT swissprot:YFER_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFER_ECOLI PSORT-B swissprot:YFER_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFER_ECOLI PSORT2 swissprot:YFER_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFER_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:YFER_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFER_ECOLI PhylomeDB P0ACR7 http://phylomedb.org/?seqid=P0ACR7 ProteinModelPortal P0ACR7 http://www.proteinmodelportal.org/query/uniprot/P0ACR7 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416904 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416904 RefSeq WP_001109794 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001109794 SMR P0ACR7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACR7 STRING 511145.b2409 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2409&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB YFER_ECOLI http://www.uniprot.org/uniprot/YFER_ECOLI UniProtKB-AC P0ACR7 http://www.uniprot.org/uniprot/P0ACR7 charge swissprot:YFER_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFER_ECOLI eggNOG ENOG4108M0I http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108M0I eggNOG ENOG410XQRQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQRQ epestfind swissprot:YFER_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFER_ECOLI garnier swissprot:YFER_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFER_ECOLI helixturnhelix swissprot:YFER_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFER_ECOLI hmoment swissprot:YFER_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFER_ECOLI iep swissprot:YFER_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFER_ECOLI inforesidue swissprot:YFER_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFER_ECOLI octanol swissprot:YFER_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFER_ECOLI pepcoil swissprot:YFER_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFER_ECOLI pepdigest swissprot:YFER_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFER_ECOLI pepinfo swissprot:YFER_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFER_ECOLI pepnet swissprot:YFER_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFER_ECOLI pepstats swissprot:YFER_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFER_ECOLI pepwheel swissprot:YFER_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFER_ECOLI pepwindow swissprot:YFER_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFER_ECOLI sigcleave swissprot:YFER_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFER_ECOLI ## Database ID URL or Descriptions # BioGrid 4262220 160 # EcoGene EG12143 napD # FUNCTION NAPD_ECOLI Plays a role in the correct assembly of subunits of the periplasmic NapAB enzyme. # GO_component GO:0005737 cytoplasm; IDA:EcoCyc. # GO_function GO:0005048 signal sequence binding; IPI:EcoCyc. # GO_process GO:0051224 negative regulation of protein transport; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0008150 biological_process # INTERACTION NAPD_ECOLI P33937 napA; NbExp=8; IntAct=EBI-554985, EBI-554952; P0A9M8 pta; NbExp=2; IntAct=EBI-554985, EBI-555015; P0A8E7 yajQ; NbExp=2; IntAct=EBI-554985, EBI-370752; # IntAct P0A9I5 21 # InterPro IPR005623 Chaperone_NapD_NO3_reduct # Organism NAPD_ECOLI Escherichia coli (strain K12) # PATRIC 32119773 VBIEscCol129921_2296 # PDB 2JSX NMR; -; A=1-87 # PDB 2PQ4 NMR; -; A=1-87 # PIR E64990 E64990 # Pfam PF03927 NapD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NAPD_ECOLI Protein NapD # RefSeq NP_416711 NC_000913.3 # RefSeq WP_000557378 NZ_LN832404.1 # SUBCELLULAR LOCATION NAPD_ECOLI Cytoplasm {ECO 0000305}. # eggNOG COG3062 LUCA # eggNOG ENOG41061Q0 Bacteria BLAST swissprot:NAPD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NAPD_ECOLI BioCyc ECOL316407:JW2195-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2195-MONOMER BioCyc EcoCyc:NAPD-MONOMER http://biocyc.org/getid?id=EcoCyc:NAPD-MONOMER COG COG3062 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3062 DIP DIP-46322N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-46322N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00008 http://www.ebi.ac.uk/ena/data/view/U00008 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2064 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2064 EcoGene EG12143 http://www.ecogene.org/geneInfo.php?eg_id=EG12143 EnsemblBacteria AAC75267 http://www.ensemblgenomes.org/id/AAC75267 EnsemblBacteria AAC75267 http://www.ensemblgenomes.org/id/AAC75267 EnsemblBacteria BAA15990 http://www.ensemblgenomes.org/id/BAA15990 EnsemblBacteria BAA15990 http://www.ensemblgenomes.org/id/BAA15990 EnsemblBacteria BAA15990 http://www.ensemblgenomes.org/id/BAA15990 EnsemblBacteria b2207 http://www.ensemblgenomes.org/id/b2207 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0005048 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005048 GO_process GO:0051224 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051224 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 945187 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945187 HOGENOM HOG000275488 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275488&db=HOGENOM6 InParanoid P0A9I5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9I5 IntAct P0A9I5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9I5* InterPro IPR005623 http://www.ebi.ac.uk/interpro/entry/IPR005623 KEGG_Gene ecj:JW2195 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2195 KEGG_Gene eco:b2207 http://www.genome.jp/dbget-bin/www_bget?eco:b2207 KEGG_Orthology KO:K02570 http://www.genome.jp/dbget-bin/www_bget?KO:K02570 MINT MINT-1226955 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1226955 OMA MNNEWHV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MNNEWHV PDB 2JSX http://www.ebi.ac.uk/pdbe-srv/view/entry/2JSX PDB 2PQ4 http://www.ebi.ac.uk/pdbe-srv/view/entry/2PQ4 PDBsum 2JSX http://www.ebi.ac.uk/pdbsum/2JSX PDBsum 2PQ4 http://www.ebi.ac.uk/pdbsum/2PQ4 PSORT swissprot:NAPD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NAPD_ECOLI PSORT-B swissprot:NAPD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NAPD_ECOLI PSORT2 swissprot:NAPD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NAPD_ECOLI Pfam PF03927 http://pfam.xfam.org/family/PF03927 Phobius swissprot:NAPD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NAPD_ECOLI PhylomeDB P0A9I5 http://phylomedb.org/?seqid=P0A9I5 ProteinModelPortal P0A9I5 http://www.proteinmodelportal.org/query/uniprot/P0A9I5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416711 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416711 RefSeq WP_000557378 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000557378 SMR P0A9I5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9I5 STRING 511145.b2207 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2207&targetmode=cogs STRING COG3062 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3062&targetmode=cogs UniProtKB NAPD_ECOLI http://www.uniprot.org/uniprot/NAPD_ECOLI UniProtKB-AC P0A9I5 http://www.uniprot.org/uniprot/P0A9I5 charge swissprot:NAPD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NAPD_ECOLI eggNOG COG3062 http://eggnogapi.embl.de/nog_data/html/tree/COG3062 eggNOG ENOG41061Q0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41061Q0 epestfind swissprot:NAPD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NAPD_ECOLI garnier swissprot:NAPD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NAPD_ECOLI helixturnhelix swissprot:NAPD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NAPD_ECOLI hmoment swissprot:NAPD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NAPD_ECOLI iep swissprot:NAPD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NAPD_ECOLI inforesidue swissprot:NAPD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NAPD_ECOLI octanol swissprot:NAPD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NAPD_ECOLI pepcoil swissprot:NAPD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NAPD_ECOLI pepdigest swissprot:NAPD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NAPD_ECOLI pepinfo swissprot:NAPD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NAPD_ECOLI pepnet swissprot:NAPD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NAPD_ECOLI pepstats swissprot:NAPD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NAPD_ECOLI pepwheel swissprot:NAPD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NAPD_ECOLI pepwindow swissprot:NAPD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NAPD_ECOLI sigcleave swissprot:NAPD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NAPD_ECOLI ## Database ID URL or Descriptions # BioGrid 4260791 16 # CDD cd01734 YlxS_C # DISRUPTION PHENOTYPE Cells lacking this gene show a reduced growth rate, especially at high temperatures. They show a reduced amount of 70S ribosomes engaged in translation and a corresponding increase in the amount of free ribosomal subunits. {ECO:0000269|PubMed 19150615}. # EcoGene EG11179 rimP # FUNCTION RIMP_ECOLI Required for maturation of 30S ribosomal subunits, probably at a late stage of ribosomal protein binding, while Era is associated and after RimM. {ECO 0000269|PubMed 19150615, ECO 0000269|PubMed 20188109}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_process GO:0000028 ribosomal small subunit assembly; IMP:EcoCyc. # GO_process GO:0006412 translation; IMP:EcoliWiki. # GO_process GO:0042274 ribosomal small subunit biogenesis; IMP:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_process GO:0006412 translation # GOslim_process GO:0008150 biological_process # GOslim_process GO:0022618 ribonucleoprotein complex assembly # Gene3D 2.30.30.180 -; 1. # Gene3D 3.30.300.70 -; 1. # HAMAP MF_01077 RimP # INTERACTION RIMP_ECOLI P0A7S3 rpsL; NbExp=3; IntAct=EBI-561065, EBI-543960; # IntAct P0A8A8 7 # InterPro IPR003728 Ribosome_maturation_RimP # InterPro IPR028989 RimP_N # InterPro IPR028998 RimP_C # KEGG_Brite ko03009 Ribosome biogenesis # Organism RIMP_ECOLI Escherichia coli (strain K12) # PATRIC 32121758 VBIEscCol129921_3265 # PIR F65107 WMECN5 # Pfam PF02576 DUF150 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RIMP_ECOLI Ribosome maturation factor RimP # RefSeq NP_417639 NC_000913.3 # RefSeq WP_001300397 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA57973.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA25199.1; Type=Frameshift; Positions=7; Evidence={ECO 0000305}; # SIMILARITY Belongs to the RimP family. {ECO 0000305}. # SUBCELLULAR LOCATION RIMP_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT RIMP_ECOLI Associates with free 30S subunits, but not with free 50S subunits or with mature ribosomes. # SUPFAM SSF74942 SSF74942 # SUPFAM SSF75420 SSF75420 # eggNOG COG0779 LUCA # eggNOG ENOG4105K7D Bacteria BLAST swissprot:RIMP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RIMP_ECOLI BioCyc ECOL316407:JW5533-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5533-MONOMER BioCyc EcoCyc:EG11179-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11179-MONOMER COG COG0779 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0779 DIP DIP-47892N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47892N DOI 10.1016/j.jmb.2008.12.076 http://dx.doi.org/10.1016/j.jmb.2008.12.076 DOI 10.1016/j.jmb.2010.02.036 http://dx.doi.org/10.1016/j.jmb.2010.02.036 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/12.7.3333 http://dx.doi.org/10.1093/nar/12.7.3333 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X00513 http://www.ebi.ac.uk/ena/data/view/X00513 EchoBASE EB1166 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1166 EcoGene EG11179 http://www.ecogene.org/geneInfo.php?eg_id=EG11179 EnsemblBacteria AAC76204 http://www.ensemblgenomes.org/id/AAC76204 EnsemblBacteria AAC76204 http://www.ensemblgenomes.org/id/AAC76204 EnsemblBacteria BAE77216 http://www.ensemblgenomes.org/id/BAE77216 EnsemblBacteria BAE77216 http://www.ensemblgenomes.org/id/BAE77216 EnsemblBacteria BAE77216 http://www.ensemblgenomes.org/id/BAE77216 EnsemblBacteria b3170 http://www.ensemblgenomes.org/id/b3170 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_process GO:0000028 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000028 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GO_process GO:0042274 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042274 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0022618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022618 Gene3D 2.30.30.180 http://www.cathdb.info/version/latest/superfamily/2.30.30.180 Gene3D 3.30.300.70 http://www.cathdb.info/version/latest/superfamily/3.30.300.70 GeneID 947680 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947680 HAMAP MF_01077 http://hamap.expasy.org/unirule/MF_01077 HOGENOM HOG000242360 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000242360&db=HOGENOM6 InParanoid P0A8A8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8A8 IntAct P0A8A8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8A8* InterPro IPR003728 http://www.ebi.ac.uk/interpro/entry/IPR003728 InterPro IPR028989 http://www.ebi.ac.uk/interpro/entry/IPR028989 InterPro IPR028998 http://www.ebi.ac.uk/interpro/entry/IPR028998 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW5533 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5533 KEGG_Gene eco:b3170 http://www.genome.jp/dbget-bin/www_bget?eco:b3170 KEGG_Orthology KO:K09748 http://www.genome.jp/dbget-bin/www_bget?KO:K09748 MINT MINT-1219023 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1219023 PSORT swissprot:RIMP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RIMP_ECOLI PSORT-B swissprot:RIMP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RIMP_ECOLI PSORT2 swissprot:RIMP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RIMP_ECOLI Pfam PF02576 http://pfam.xfam.org/family/PF02576 Phobius swissprot:RIMP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RIMP_ECOLI PhylomeDB P0A8A8 http://phylomedb.org/?seqid=P0A8A8 ProteinModelPortal P0A8A8 http://www.proteinmodelportal.org/query/uniprot/P0A8A8 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19150615 http://www.ncbi.nlm.nih.gov/pubmed/19150615 PubMed 20188109 http://www.ncbi.nlm.nih.gov/pubmed/20188109 PubMed 6326058 http://www.ncbi.nlm.nih.gov/pubmed/6326058 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417639 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417639 RefSeq WP_001300397 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300397 SMR P0A8A8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8A8 STRING 511145.b3170 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3170&targetmode=cogs STRING COG0779 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0779&targetmode=cogs SUPFAM SSF74942 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF74942 SUPFAM SSF75420 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF75420 UniProtKB RIMP_ECOLI http://www.uniprot.org/uniprot/RIMP_ECOLI UniProtKB-AC P0A8A8 http://www.uniprot.org/uniprot/P0A8A8 charge swissprot:RIMP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RIMP_ECOLI eggNOG COG0779 http://eggnogapi.embl.de/nog_data/html/tree/COG0779 eggNOG ENOG4105K7D http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K7D epestfind swissprot:RIMP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RIMP_ECOLI garnier swissprot:RIMP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RIMP_ECOLI helixturnhelix swissprot:RIMP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RIMP_ECOLI hmoment swissprot:RIMP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RIMP_ECOLI iep swissprot:RIMP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RIMP_ECOLI inforesidue swissprot:RIMP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RIMP_ECOLI octanol swissprot:RIMP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RIMP_ECOLI pepcoil swissprot:RIMP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RIMP_ECOLI pepdigest swissprot:RIMP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RIMP_ECOLI pepinfo swissprot:RIMP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RIMP_ECOLI pepnet swissprot:RIMP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RIMP_ECOLI pepstats swissprot:RIMP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RIMP_ECOLI pepwheel swissprot:RIMP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RIMP_ECOLI pepwindow swissprot:RIMP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RIMP_ECOLI sigcleave swissprot:RIMP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RIMP_ECOLI ## Database ID URL or Descriptions # AltName YDFW_ECOLI Uncharacterized protein YdfW in Qin prophage region # BioGrid 4260699 97 # EcoGene EG13835 ydfW # IntAct P76164 2 # Organism YDFW_ECOLI Escherichia coli (strain K12) # PIR B64912 B64912 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Uncharacterized protein YdfW {ECO 0000305} BLAST swissprot:YDFW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDFW_ECOLI BioCyc ECOL316407:JW1559-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1559-MONOMER BioCyc EcoCyc:G6834-MONOMER http://biocyc.org/getid?id=EcoCyc:G6834-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3596 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3596 EcoGene EG13835 http://www.ecogene.org/geneInfo.php?eg_id=EG13835 EnsemblBacteria BAE76473 http://www.ensemblgenomes.org/id/BAE76473 EnsemblBacteria BAE76473 http://www.ensemblgenomes.org/id/BAE76473 EnsemblBacteria BAE76473 http://www.ensemblgenomes.org/id/BAE76473 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv IntAct P76164 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76164* KEGG_Gene ecj:JW1559 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1559 PSORT swissprot:YDFW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDFW_ECOLI PSORT-B swissprot:YDFW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDFW_ECOLI PSORT2 swissprot:YDFW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDFW_ECOLI Phobius swissprot:YDFW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDFW_ECOLI ProteinModelPortal P76164 http://www.proteinmodelportal.org/query/uniprot/P76164 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SMR P76164 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76164 UniProtKB YDFW_ECOLI http://www.uniprot.org/uniprot/YDFW_ECOLI UniProtKB-AC P76164 http://www.uniprot.org/uniprot/P76164 charge swissprot:YDFW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDFW_ECOLI epestfind swissprot:YDFW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDFW_ECOLI garnier swissprot:YDFW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDFW_ECOLI helixturnhelix swissprot:YDFW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDFW_ECOLI hmoment swissprot:YDFW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDFW_ECOLI iep swissprot:YDFW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDFW_ECOLI inforesidue swissprot:YDFW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDFW_ECOLI octanol swissprot:YDFW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDFW_ECOLI pepcoil swissprot:YDFW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDFW_ECOLI pepdigest swissprot:YDFW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDFW_ECOLI pepinfo swissprot:YDFW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDFW_ECOLI pepnet swissprot:YDFW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDFW_ECOLI pepstats swissprot:YDFW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDFW_ECOLI pepwheel swissprot:YDFW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDFW_ECOLI pepwindow swissprot:YDFW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDFW_ECOLI sigcleave swissprot:YDFW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDFW_ECOLI ## Database ID URL or Descriptions # AltName PAAB_ECOLI 1,2-phenylacetyl-CoA monooxygenase, subunit B # BioGrid 4261630 132 # EcoGene EG14299 paaB # FUNCTION PAAB_ECOLI Component of 1,2-phenylacetyl-CoA epoxidase multicomponent enzyme system which catalyzes the reduction of phenylacetyl-CoA (PA-CoA) to form 1,2-epoxyphenylacetyl-CoA. The subunit B may play a regulatory role or be directly involved in electron transport. {ECO 0000269|PubMed 16997993, ECO 0000269|PubMed 20660314, ECO 0000269|PubMed 9748275}. # GO_process GO:0010124 phenylacetate catabolic process; IMP:UniProtKB. # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # INDUCTION PAAB_ECOLI Activated by cAMP receptor protein (CRP), integration host factor (IHF) and by phenylacetyl-coenzyme A (PA-CoA) that prevents PaaX from binding its target sequences. Inhibited by PaaX. {ECO 0000269|PubMed 10766858, ECO 0000269|PubMed 9748275}. # IntAct P76078 12 # InterPro IPR009359 PaaB # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko00360 Phenylalanine metabolism # Organism PAAB_ECOLI Escherichia coli (strain K12) # PATHWAY PAAB_ECOLI Aromatic compound metabolism; phenylacetate degradation. # PATRIC 32118064 VBIEscCol129921_1452 # PIR H64889 H64889 # PIRSF PIRSF030200 PaaB # Pfam PF06243 PaaB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PAAB_ECOLI 1,2-phenylacetyl-CoA epoxidase, subunit B # RefSeq NP_415907 NC_000913.3 # RefSeq WP_000073393 NZ_LN832404.1 # SUBUNIT Homotrimer. Forms a stable heterodimer with PaaC. Probably forms an oligomer with PaaAC. {ECO:0000269|PubMed 21247899}. # TIGRFAMs TIGR02157 PA_CoA_Oxy2 # eggNOG COG3460 LUCA # eggNOG ENOG4105N76 Bacteria BLAST swissprot:PAAB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PAAB_ECOLI BioCyc ECOL316407:JW1384-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1384-MONOMER BioCyc EcoCyc:G6710-MONOMER http://biocyc.org/getid?id=EcoCyc:G6710-MONOMER BioCyc MetaCyc:G6710-MONOMER http://biocyc.org/getid?id=MetaCyc:G6710-MONOMER COG COG3460 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3460 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.1005399107 http://dx.doi.org/10.1073/pnas.1005399107 DOI 10.1074/jbc.273.40.25974 http://dx.doi.org/10.1074/jbc.273.40.25974 DOI 10.1074/jbc.275.16.12214 http://dx.doi.org/10.1074/jbc.275.16.12214 DOI 10.1074/jbc.M110.194423 http://dx.doi.org/10.1074/jbc.M110.194423 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AEM.01550-06 http://dx.doi.org/10.1128/AEM.01550-06 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X97452 http://www.ebi.ac.uk/ena/data/view/X97452 EchoBASE EB4046 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4046 EcoGene EG14299 http://www.ecogene.org/geneInfo.php?eg_id=EG14299 EnsemblBacteria AAC74471 http://www.ensemblgenomes.org/id/AAC74471 EnsemblBacteria AAC74471 http://www.ensemblgenomes.org/id/AAC74471 EnsemblBacteria BAE76424 http://www.ensemblgenomes.org/id/BAE76424 EnsemblBacteria BAE76424 http://www.ensemblgenomes.org/id/BAE76424 EnsemblBacteria BAE76424 http://www.ensemblgenomes.org/id/BAE76424 EnsemblBacteria b1389 http://www.ensemblgenomes.org/id/b1389 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0010124 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010124 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 947595 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947595 HOGENOM HOG000249734 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000249734&db=HOGENOM6 InParanoid P76078 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76078 IntAct P76078 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76078* InterPro IPR009359 http://www.ebi.ac.uk/interpro/entry/IPR009359 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW1384 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1384 KEGG_Gene eco:b1389 http://www.genome.jp/dbget-bin/www_bget?eco:b1389 KEGG_Orthology KO:K02610 http://www.genome.jp/dbget-bin/www_bget?KO:K02610 KEGG_Pathway ko00360 http://www.genome.jp/kegg-bin/show_pathway?ko00360 KEGG_Reaction rn:R09838 http://www.genome.jp/dbget-bin/www_bget?rn:R09838 OMA EWPLYEV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EWPLYEV PSORT swissprot:PAAB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PAAB_ECOLI PSORT-B swissprot:PAAB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PAAB_ECOLI PSORT2 swissprot:PAAB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PAAB_ECOLI Pfam PF06243 http://pfam.xfam.org/family/PF06243 Phobius swissprot:PAAB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PAAB_ECOLI PhylomeDB P76078 http://phylomedb.org/?seqid=P76078 ProteinModelPortal P76078 http://www.proteinmodelportal.org/query/uniprot/P76078 PubMed 10766858 http://www.ncbi.nlm.nih.gov/pubmed/10766858 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16997993 http://www.ncbi.nlm.nih.gov/pubmed/16997993 PubMed 20660314 http://www.ncbi.nlm.nih.gov/pubmed/20660314 PubMed 21247899 http://www.ncbi.nlm.nih.gov/pubmed/21247899 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9748275 http://www.ncbi.nlm.nih.gov/pubmed/9748275 RefSeq NP_415907 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415907 RefSeq WP_000073393 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000073393 SMR P76078 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76078 STRING 511145.b1389 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1389&targetmode=cogs STRING COG3460 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3460&targetmode=cogs TIGRFAMs TIGR02157 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02157 UniProtKB PAAB_ECOLI http://www.uniprot.org/uniprot/PAAB_ECOLI UniProtKB-AC P76078 http://www.uniprot.org/uniprot/P76078 charge swissprot:PAAB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PAAB_ECOLI eggNOG COG3460 http://eggnogapi.embl.de/nog_data/html/tree/COG3460 eggNOG ENOG4105N76 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105N76 epestfind swissprot:PAAB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PAAB_ECOLI garnier swissprot:PAAB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PAAB_ECOLI helixturnhelix swissprot:PAAB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PAAB_ECOLI hmoment swissprot:PAAB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PAAB_ECOLI iep swissprot:PAAB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PAAB_ECOLI inforesidue swissprot:PAAB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PAAB_ECOLI octanol swissprot:PAAB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PAAB_ECOLI pepcoil swissprot:PAAB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PAAB_ECOLI pepdigest swissprot:PAAB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PAAB_ECOLI pepinfo swissprot:PAAB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PAAB_ECOLI pepnet swissprot:PAAB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PAAB_ECOLI pepstats swissprot:PAAB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PAAB_ECOLI pepwheel swissprot:PAAB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PAAB_ECOLI pepwindow swissprot:PAAB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PAAB_ECOLI sigcleave swissprot:PAAB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PAAB_ECOLI ## Database ID URL or Descriptions # AltName FLMA_ECOLI F leading maintenance protein # FUNCTION FLMA_ECOLI FlmA extends the life of unstable plasmids. # FUNCTION FLMA_ECOLI When overexpressed kills the cells from the inside by interfering with a vital function in the cell membrane. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # InterPro IPR000021 Hok/gef_toxin # InterPro IPR018084 Hok/gef_toxin_CS # Organism FLMA_ECOLI Escherichia coli (strain K12) # PIR JS0432 BVECMA # PRINTS PR00281 HOKGEFTOXIC # PROSITE PS00556 HOK_GEF # Pfam PF01848 HOK_GEF # ProDom PD005979 Hok/gef_toxin # RecName FLMA_ECOLI Stable plasmid inheritance protein # RefSeq NP_061445 NC_002483.1 # RefSeq WP_001302184 NZ_CP014273.1 # RefSeq YP_001816514 NC_010558.1 # RefSeq YP_009071221 NC_025179.1 # SIMILARITY Belongs to the hok/gef family. {ECO 0000305}. # SUBCELLULAR LOCATION FLMA_ECOLI Membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. BLAST swissprot:FLMA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLMA_ECOLI DOI 10.1007/BF00337735 http://dx.doi.org/10.1007/BF00337735 DOI 10.1016/0378-1119(88)90362-9 http://dx.doi.org/10.1016/0378-1119(88)90362-9 EMBL AF106329 http://www.ebi.ac.uk/ena/data/view/AF106329 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL X13521 http://www.ebi.ac.uk/ena/data/view/X13521 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GeneID 1263569 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263569 GeneID 20493293 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20493293 GeneID 6275929 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6275929 InterPro IPR000021 http://www.ebi.ac.uk/interpro/entry/IPR000021 InterPro IPR018084 http://www.ebi.ac.uk/interpro/entry/IPR018084 OMA NIRIASY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NIRIASY PRINTS PR00281 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00281 PROSITE PS00556 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00556 PSORT swissprot:FLMA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLMA_ECOLI PSORT-B swissprot:FLMA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLMA_ECOLI PSORT2 swissprot:FLMA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLMA_ECOLI Pfam PF01848 http://pfam.xfam.org/family/PF01848 Phobius swissprot:FLMA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLMA_ECOLI PhylomeDB P62670 http://phylomedb.org/?seqid=P62670 ProteinModelPortal P62670 http://www.proteinmodelportal.org/query/uniprot/P62670 PubMed 3049248 http://www.ncbi.nlm.nih.gov/pubmed/3049248 PubMed 3070354 http://www.ncbi.nlm.nih.gov/pubmed/3070354 RefSeq NP_061445 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061445 RefSeq WP_001302184 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001302184 RefSeq YP_001816514 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001816514 RefSeq YP_009071221 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009071221 UniProtKB FLMA_ECOLI http://www.uniprot.org/uniprot/FLMA_ECOLI UniProtKB-AC P62670 http://www.uniprot.org/uniprot/P62670 charge swissprot:FLMA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLMA_ECOLI epestfind swissprot:FLMA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLMA_ECOLI garnier swissprot:FLMA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLMA_ECOLI helixturnhelix swissprot:FLMA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLMA_ECOLI hmoment swissprot:FLMA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLMA_ECOLI iep swissprot:FLMA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLMA_ECOLI inforesidue swissprot:FLMA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLMA_ECOLI octanol swissprot:FLMA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLMA_ECOLI pepcoil swissprot:FLMA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLMA_ECOLI pepdigest swissprot:FLMA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLMA_ECOLI pepinfo swissprot:FLMA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLMA_ECOLI pepnet swissprot:FLMA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLMA_ECOLI pepstats swissprot:FLMA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLMA_ECOLI pepwheel swissprot:FLMA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLMA_ECOLI pepwindow swissprot:FLMA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLMA_ECOLI sigcleave swissprot:FLMA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLMA_ECOLI ## Database ID URL or Descriptions # AltName RUTR_ECOLI Rut operon repressor # EcoGene EG12301 rutR # FUNCTION RUTR_ECOLI Master transcription regulator which represses the degradation of pyrimidines (rutABCDEFG) and purines (gcl operon) for maintenance of metabolic balance between pyrimidines and purines. It also regulates the synthesis of pyrimidine nucleotides and arginine from glutamine (carAB) and the supply of glutamate (gadABWX). {ECO 0000269|PubMed 16540542, ECO 0000269|PubMed 17919280}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0000976 transcription regulatory region sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IDA:UniProtKB. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IDA:UniProtKB. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.60 -; 2. # Gene3D 1.10.357.10 -; 1. # INTERACTION RUTR_ECOLI P04951 kdsB; NbExp=2; IntAct=EBI-1121539, EBI-544810; # IntAct P0ACU2 23 # InterPro IPR001647 HTH_TetR # InterPro IPR009057 Homeodomain-like # InterPro IPR011075 Tet_transcr_reg_TetR-rel_C # InterPro IPR013573 Tscrpt_reg_YcdC_C # InterPro IPR015893 Tet_transcr_reg_TetR-like_C # InterPro IPR019915 Tscrpt_reg_pyr_util_RutR # KEGG_Brite ko03000 Transcription factors # MISCELLANEOUS RUTR_ECOLI The Rut pathway degrades exogenous pyrimidines as the sole nitrogen source at room temperature but not at 37 degrees Celsius, a restriction that is apparently a consequence of an inadequate ability to remove toxic malonic semialdehyde at the higher temperature (RutE/YdfG function). # Organism RUTR_ECOLI Escherichia coli (strain K12) # PATRIC 32117255 VBIEscCol129921_1051 # PDB 3LOC X-ray; 2.50 A; A/B/C/D=1-212 # PDB 4JYK X-ray; 1.70 A; A/B=1-212 # PDB 4X1E X-ray; 2.40 A; A/B=1-212 # PDB 4XK4 X-ray; 2.27 A; A/B/C/D=1-212 # PIR C64843 C64843 # PRINTS PR00455 HTHTETR # PROSITE PS50977 HTH_TETR_2 # Pfam PF00440 TetR_N # Pfam PF08362 TetR_C_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RUTR_ECOLI HTH-type transcriptional regulator RutR # RefSeq NP_415533 NC_000913.3 # RefSeq WP_000191701 NZ_LN832404.1 # SIMILARITY Contains 1 HTH tetR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00335}. # SUBUNIT Homodimer. {ECO 0000269|Ref.6}. # SUPFAM SSF46689 SSF46689 # SUPFAM SSF48498 SSF48498 # TIGRFAMs TIGR03613 RutR # eggNOG COG1309 LUCA # eggNOG ENOG4108R86 Bacteria BLAST swissprot:RUTR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RUTR_ECOLI BioCyc ECOL316407:JW0998-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0998-MONOMER BioCyc EcoCyc:PD01352 http://biocyc.org/getid?id=EcoCyc:PD01352 COG COG1309 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1309 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0600521103 http://dx.doi.org/10.1073/pnas.0600521103 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.2007.05954.x http://dx.doi.org/10.1111/j.1365-2958.2007.05954.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2207 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2207 EcoGene EG12301 http://www.ecogene.org/geneInfo.php?eg_id=EG12301 EnsemblBacteria AAC74098 http://www.ensemblgenomes.org/id/AAC74098 EnsemblBacteria AAC74098 http://www.ensemblgenomes.org/id/AAC74098 EnsemblBacteria BAA35790 http://www.ensemblgenomes.org/id/BAA35790 EnsemblBacteria BAA35790 http://www.ensemblgenomes.org/id/BAA35790 EnsemblBacteria BAA35790 http://www.ensemblgenomes.org/id/BAA35790 EnsemblBacteria b1013 http://www.ensemblgenomes.org/id/b1013 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000976 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000976 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 Gene3D 1.10.357.10 http://www.cathdb.info/version/latest/superfamily/1.10.357.10 GeneID 945075 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945075 HOGENOM HOG000267645 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267645&db=HOGENOM6 InParanoid P0ACU2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACU2 IntAct P0ACU2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACU2* InterPro IPR001647 http://www.ebi.ac.uk/interpro/entry/IPR001647 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR011075 http://www.ebi.ac.uk/interpro/entry/IPR011075 InterPro IPR013573 http://www.ebi.ac.uk/interpro/entry/IPR013573 InterPro IPR015893 http://www.ebi.ac.uk/interpro/entry/IPR015893 InterPro IPR019915 http://www.ebi.ac.uk/interpro/entry/IPR019915 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW0998 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0998 KEGG_Gene eco:b1013 http://www.genome.jp/dbget-bin/www_bget?eco:b1013 KEGG_Orthology KO:K09017 http://www.genome.jp/dbget-bin/www_bget?KO:K09017 OMA FCLEMIQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FCLEMIQ PDB 3LOC http://www.ebi.ac.uk/pdbe-srv/view/entry/3LOC PDB 4JYK http://www.ebi.ac.uk/pdbe-srv/view/entry/4JYK PDB 4X1E http://www.ebi.ac.uk/pdbe-srv/view/entry/4X1E PDB 4XK4 http://www.ebi.ac.uk/pdbe-srv/view/entry/4XK4 PDBsum 3LOC http://www.ebi.ac.uk/pdbsum/3LOC PDBsum 4JYK http://www.ebi.ac.uk/pdbsum/4JYK PDBsum 4X1E http://www.ebi.ac.uk/pdbsum/4X1E PDBsum 4XK4 http://www.ebi.ac.uk/pdbsum/4XK4 PRINTS PR00455 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00455 PROSITE PS50977 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50977 PSORT swissprot:RUTR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RUTR_ECOLI PSORT-B swissprot:RUTR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RUTR_ECOLI PSORT2 swissprot:RUTR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RUTR_ECOLI Pfam PF00440 http://pfam.xfam.org/family/PF00440 Pfam PF08362 http://pfam.xfam.org/family/PF08362 Phobius swissprot:RUTR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RUTR_ECOLI PhylomeDB P0ACU2 http://phylomedb.org/?seqid=P0ACU2 ProteinModelPortal P0ACU2 http://www.proteinmodelportal.org/query/uniprot/P0ACU2 PubMed 16540542 http://www.ncbi.nlm.nih.gov/pubmed/16540542 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17919280 http://www.ncbi.nlm.nih.gov/pubmed/17919280 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415533 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415533 RefSeq WP_000191701 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000191701 SMR P0ACU2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACU2 STRING 511145.b1013 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1013&targetmode=cogs STRING COG1309 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1309&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF48498 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48498 TIGRFAMs TIGR03613 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03613 UniProtKB RUTR_ECOLI http://www.uniprot.org/uniprot/RUTR_ECOLI UniProtKB-AC P0ACU2 http://www.uniprot.org/uniprot/P0ACU2 charge swissprot:RUTR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RUTR_ECOLI eggNOG COG1309 http://eggnogapi.embl.de/nog_data/html/tree/COG1309 eggNOG ENOG4108R86 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108R86 epestfind swissprot:RUTR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RUTR_ECOLI garnier swissprot:RUTR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RUTR_ECOLI helixturnhelix swissprot:RUTR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RUTR_ECOLI hmoment swissprot:RUTR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RUTR_ECOLI iep swissprot:RUTR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RUTR_ECOLI inforesidue swissprot:RUTR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RUTR_ECOLI octanol swissprot:RUTR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RUTR_ECOLI pepcoil swissprot:RUTR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RUTR_ECOLI pepdigest swissprot:RUTR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RUTR_ECOLI pepinfo swissprot:RUTR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RUTR_ECOLI pepnet swissprot:RUTR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RUTR_ECOLI pepstats swissprot:RUTR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RUTR_ECOLI pepwheel swissprot:RUTR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RUTR_ECOLI pepwindow swissprot:RUTR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RUTR_ECOLI sigcleave swissprot:RUTR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RUTR_ECOLI ## Database ID URL or Descriptions # BioGrid 4260241 9 # CDD cd04458 CSP_CDS # EcoGene EG12205 cspF # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # InterPro IPR002059 CSP_DNA-bd # InterPro IPR011129 Cold_shock_prot # InterPro IPR012156 Cold_shock_CspA # InterPro IPR012340 NA-bd_OB-fold # InterPro IPR019844 Cold-shock_CS # KEGG_Brite ko03000 Transcription factors # Organism CSPF_ECOLI Escherichia coli (strain K12) # PATRIC 32118418 VBIEscCol129921_1629 # PIR A64911 A64911 # PIRSF PIRSF002599 Cold_shock_A # PROSITE PS00352 COLD_SHOCK # Pfam PF00313 CSD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CSPF_ECOLI Cold shock-like protein CspF # RefSeq NP_416076 NC_000913.3 # RefSeq WP_000087756 NZ_LN832404.1 # SIMILARITY Contains 1 CSD (cold-shock) domain. {ECO 0000305}. # SMART SM00357 CSP # SUBCELLULAR LOCATION CSPF_ECOLI Cytoplasm {ECO 0000250}. # SUPFAM SSF50249 SSF50249 # eggNOG COG1278 LUCA BLAST swissprot:CSPF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CSPF_ECOLI BioCyc ECOL316407:JW1550-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1550-MONOMER BioCyc EcoCyc:EG12205-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12205-MONOMER COG COG1278 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1278 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/sj.jim.2900463 http://dx.doi.org/10.1038/sj.jim.2900463 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1111/j.1365-2958.1994.tb00361.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb00361.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AF003590 http://www.ebi.ac.uk/ena/data/view/AF003590 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L28429 http://www.ebi.ac.uk/ena/data/view/L28429 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2121 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2121 EcoGene EG12205 http://www.ecogene.org/geneInfo.php?eg_id=EG12205 EnsemblBacteria AAC74631 http://www.ensemblgenomes.org/id/AAC74631 EnsemblBacteria AAC74631 http://www.ensemblgenomes.org/id/AAC74631 EnsemblBacteria BAA15257 http://www.ensemblgenomes.org/id/BAA15257 EnsemblBacteria BAA15257 http://www.ensemblgenomes.org/id/BAA15257 EnsemblBacteria BAA15257 http://www.ensemblgenomes.org/id/BAA15257 EnsemblBacteria b1558 http://www.ensemblgenomes.org/id/b1558 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 946090 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946090 HOGENOM HOG000070674 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000070674&db=HOGENOM6 InParanoid P0A976 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A976 InterPro IPR002059 http://www.ebi.ac.uk/interpro/entry/IPR002059 InterPro IPR011129 http://www.ebi.ac.uk/interpro/entry/IPR011129 InterPro IPR012156 http://www.ebi.ac.uk/interpro/entry/IPR012156 InterPro IPR012340 http://www.ebi.ac.uk/interpro/entry/IPR012340 InterPro IPR019844 http://www.ebi.ac.uk/interpro/entry/IPR019844 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW1550 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1550 KEGG_Gene eco:b1558 http://www.genome.jp/dbget-bin/www_bget?eco:b1558 KEGG_Orthology KO:K03704 http://www.genome.jp/dbget-bin/www_bget?KO:K03704 OMA KMTGILK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KMTGILK PROSITE PS00352 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00352 PSORT swissprot:CSPF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CSPF_ECOLI PSORT-B swissprot:CSPF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CSPF_ECOLI PSORT2 swissprot:CSPF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CSPF_ECOLI Pfam PF00313 http://pfam.xfam.org/family/PF00313 Phobius swissprot:CSPF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CSPF_ECOLI PhylomeDB P0A976 http://phylomedb.org/?seqid=P0A976 ProteinModelPortal P0A976 http://www.proteinmodelportal.org/query/uniprot/P0A976 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8022261 http://www.ncbi.nlm.nih.gov/pubmed/8022261 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9439003 http://www.ncbi.nlm.nih.gov/pubmed/9439003 RefSeq NP_416076 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416076 RefSeq WP_000087756 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000087756 SMART SM00357 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00357 SMR P0A976 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A976 STRING 511145.b1558 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1558&targetmode=cogs STRING COG1278 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1278&targetmode=cogs SUPFAM SSF50249 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50249 UniProtKB CSPF_ECOLI http://www.uniprot.org/uniprot/CSPF_ECOLI UniProtKB-AC P0A976 http://www.uniprot.org/uniprot/P0A976 charge swissprot:CSPF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CSPF_ECOLI eggNOG COG1278 http://eggnogapi.embl.de/nog_data/html/tree/COG1278 epestfind swissprot:CSPF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CSPF_ECOLI garnier swissprot:CSPF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CSPF_ECOLI helixturnhelix swissprot:CSPF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CSPF_ECOLI hmoment swissprot:CSPF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CSPF_ECOLI iep swissprot:CSPF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CSPF_ECOLI inforesidue swissprot:CSPF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CSPF_ECOLI octanol swissprot:CSPF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CSPF_ECOLI pepcoil swissprot:CSPF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CSPF_ECOLI pepdigest swissprot:CSPF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CSPF_ECOLI pepinfo swissprot:CSPF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CSPF_ECOLI pepnet swissprot:CSPF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CSPF_ECOLI pepstats swissprot:CSPF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CSPF_ECOLI pepwheel swissprot:CSPF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CSPF_ECOLI pepwindow swissprot:CSPF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CSPF_ECOLI sigcleave swissprot:CSPF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CSPF_ECOLI ## Database ID URL or Descriptions # BioGrid 4259518 7 # EcoGene EG14340 yaaW # IntAct P75617 3 # InterPro IPR021150 Ubiq_cyt_c_chap/UPF0174 # InterPro IPR025217 DUF3944 # Organism YAAW_ECOLI Escherichia coli (strain K12) # PATRIC 32115117 VBIEscCol129921_0010 # PIR C64721 C64721 # Pfam PF03981 Ubiq_cyt_C_chap # Pfam PF13099 DUF3944 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAAW_ECOLI UPF0174 protein YaaW # RefSeq NP_414552 NC_000913.3 # RefSeq WP_001102367 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0174 family. {ECO 0000305}. # eggNOG COG4735 LUCA # eggNOG ENOG4108QUJ Bacteria BLAST swissprot:YAAW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAAW_ECOLI BioCyc ECOL316407:JW0010-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0010-MONOMER BioCyc EcoCyc:G6082-MONOMER http://biocyc.org/getid?id=EcoCyc:G6082-MONOMER DIP DIP-11163N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11163N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X67700 http://www.ebi.ac.uk/ena/data/view/X67700 EchoBASE EB4086 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4086 EcoGene EG14340 http://www.ecogene.org/geneInfo.php?eg_id=EG14340 EnsemblBacteria AAC73122 http://www.ensemblgenomes.org/id/AAC73122 EnsemblBacteria AAC73122 http://www.ensemblgenomes.org/id/AAC73122 EnsemblBacteria BAE76027 http://www.ensemblgenomes.org/id/BAE76027 EnsemblBacteria BAE76027 http://www.ensemblgenomes.org/id/BAE76027 EnsemblBacteria BAE76027 http://www.ensemblgenomes.org/id/BAE76027 EnsemblBacteria b0011 http://www.ensemblgenomes.org/id/b0011 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 944771 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944771 HOGENOM HOG000116686 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000116686&db=HOGENOM6 IntAct P75617 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75617* InterPro IPR021150 http://www.ebi.ac.uk/interpro/entry/IPR021150 InterPro IPR025217 http://www.ebi.ac.uk/interpro/entry/IPR025217 KEGG_Gene ecj:JW0010 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0010 KEGG_Gene eco:b0011 http://www.genome.jp/dbget-bin/www_bget?eco:b0011 OMA YRRNWQL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YRRNWQL PSORT swissprot:YAAW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAAW_ECOLI PSORT-B swissprot:YAAW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAAW_ECOLI PSORT2 swissprot:YAAW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAAW_ECOLI Pfam PF03981 http://pfam.xfam.org/family/PF03981 Pfam PF13099 http://pfam.xfam.org/family/PF13099 Phobius swissprot:YAAW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAAW_ECOLI ProteinModelPortal P75617 http://www.proteinmodelportal.org/query/uniprot/P75617 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8400364 http://www.ncbi.nlm.nih.gov/pubmed/8400364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414552 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414552 RefSeq WP_001102367 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001102367 SMR P75617 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75617 STRING 511145.b0011 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0011&targetmode=cogs UniProtKB YAAW_ECOLI http://www.uniprot.org/uniprot/YAAW_ECOLI UniProtKB-AC P75617 http://www.uniprot.org/uniprot/P75617 charge swissprot:YAAW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAAW_ECOLI eggNOG COG4735 http://eggnogapi.embl.de/nog_data/html/tree/COG4735 eggNOG ENOG4108QUJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108QUJ epestfind swissprot:YAAW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAAW_ECOLI garnier swissprot:YAAW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAAW_ECOLI helixturnhelix swissprot:YAAW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAAW_ECOLI hmoment swissprot:YAAW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAAW_ECOLI iep swissprot:YAAW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAAW_ECOLI inforesidue swissprot:YAAW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAAW_ECOLI octanol swissprot:YAAW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAAW_ECOLI pepcoil swissprot:YAAW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAAW_ECOLI pepdigest swissprot:YAAW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAAW_ECOLI pepinfo swissprot:YAAW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAAW_ECOLI pepnet swissprot:YAAW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAAW_ECOLI pepstats swissprot:YAAW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAAW_ECOLI pepwheel swissprot:YAAW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAAW_ECOLI pepwindow swissprot:YAAW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAAW_ECOLI sigcleave swissprot:YAAW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAAW_ECOLI ## Database ID URL or Descriptions # AltName GARR_ECOLI Tartronate semialdehyde reductase {ECO 0000255|HAMAP-Rule MF_02032, ECO 0000303|PubMed 9772162} # BioGrid 4259488 17 # CATALYTIC ACTIVITY GARR_ECOLI D-glycerate + NAD(P)(+) = 2-hydroxy-3- oxopropanoate + NAD(P)H. {ECO 0000255|HAMAP-Rule MF_02032, ECO 0000269|PubMed 9772162}. # EcoGene EG11176 garR # FUNCTION GARR_ECOLI Catalyzes the reduction of tatronate semialdehyde to D- glycerate. {ECO 0000255|HAMAP-Rule MF_02032, ECO 0000269|PubMed 9772162}. # GO_function GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity; IEA:InterPro. # GO_function GO:0008679 2-hydroxy-3-oxopropionate reductase activity; IDA:EcoCyc. # GO_function GO:0051287 NAD binding; IEA:InterPro. # GO_process GO:0042838 D-glucarate catabolic process; IDA:EcoCyc. # GO_process GO:0046392 galactarate catabolic process; IDA:EcoCyc. # GO_process GO:0046487 glyoxylate metabolic process; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.1040.10 -; 1. # Gene3D 3.40.50.720 -; 1. # HAMAP MF_02032 Tartronate_sem_reduc # INDUCTION Induced by D-galactarate, D-glucarate and D-glycerate. {ECO:0000269|PubMed 10762278}. # InterPro IPR002204 3-OH-isobutyrate_DH-rel_CS # InterPro IPR006115 6PGDH_NADP-bd # InterPro IPR006398 Tartro_sem_red # InterPro IPR008927 6-PGluconate_DH_C-like # InterPro IPR013328 6PGD_dom_2 # InterPro IPR015815 HIBADH-related # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR029154 NADP-bd # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00630 Glyoxylate and dicarboxylate metabolism # Organism GARR_ECOLI Escherichia coli (strain K12) # PATHWAY GARR_ECOLI Carbohydrate acid metabolism; galactarate degradation; D- glycerate from galactarate step 3/3. {ECO 0000255|HAMAP- Rule MF_02032, ECO 0000269|PubMed 9772162}. # PATRIC 32121664 VBIEscCol129921_3218 # PIRSF PIRSF000103 HIBADH # PROSITE PS00895 3_HYDROXYISOBUT_DH # Pfam PF03446 NAD_binding_2 # Pfam PF14833 NAD_binding_11 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 2-hydroxy-3-oxopropionate reductase {ECO:0000255|HAMAP-Rule MF_02032} # RefSeq NP_417594 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA57928.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA14238.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=BAE77172.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; # SIMILARITY Belongs to the 3-hydroxyisobutyrate dehydrogenase family. {ECO:0000255|HAMAP-Rule MF_02032}. # SUPFAM SSF48179 SSF48179 # SUPFAM SSF51735 SSF51735 # TIGRFAMs TIGR01505 tartro_sem_red # UniPathway UPA00565 UER00631 # eggNOG COG2084 LUCA # eggNOG ENOG4105CF3 Bacteria BLAST swissprot:GARR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GARR_ECOLI BioCyc ECOL316407:JW5526-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5526-MONOMER BioCyc EcoCyc:TSA-REDUCT-MONOMER http://biocyc.org/getid?id=EcoCyc:TSA-REDUCT-MONOMER BioCyc MetaCyc:TSA-REDUCT-MONOMER http://biocyc.org/getid?id=MetaCyc:TSA-REDUCT-MONOMER COG COG2084 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2084 DIP DIP-9742N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9742N DOI 10.1021/bi981124f http://dx.doi.org/10.1021/bi981124f DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.9.2672-2674.2000 http://dx.doi.org/10.1128/JB.182.9.2672-2674.2000 EC_number EC:1.1.1.60 {ECO:0000255|HAMAP-Rule:MF_02032, ECO:0000269|PubMed:9772162} http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.60 {ECO:0000255|HAMAP-Rule:MF_02032, ECO:0000269|PubMed:9772162} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D90212 http://www.ebi.ac.uk/ena/data/view/D90212 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 1.1.1.60 {ECO:0000255|HAMAP-Rule:MF_02032, ECO:0000269|PubMed:9772162} http://enzyme.expasy.org/EC/1.1.1.60 {ECO:0000255|HAMAP-Rule:MF_02032, ECO:0000269|PubMed:9772162} EchoBASE EB1163 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1163 EcoGene EG11176 http://www.ecogene.org/geneInfo.php?eg_id=EG11176 EnsemblBacteria AAC76159 http://www.ensemblgenomes.org/id/AAC76159 EnsemblBacteria AAC76159 http://www.ensemblgenomes.org/id/AAC76159 EnsemblBacteria BAE77172 http://www.ensemblgenomes.org/id/BAE77172 EnsemblBacteria BAE77172 http://www.ensemblgenomes.org/id/BAE77172 EnsemblBacteria BAE77172 http://www.ensemblgenomes.org/id/BAE77172 EnsemblBacteria b3125 http://www.ensemblgenomes.org/id/b3125 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004616 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004616 GO_function GO:0008679 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008679 GO_function GO:0051287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051287 GO_process GO:0042838 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042838 GO_process GO:0046392 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046392 GO_process GO:0046487 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046487 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.1040.10 http://www.cathdb.info/version/latest/superfamily/1.10.1040.10 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 947631 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947631 HAMAP MF_02032 http://hamap.expasy.org/unirule/MF_02032 HOGENOM HOG000219608 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219608&db=HOGENOM6 InParanoid P0ABQ2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABQ2 IntEnz 1.1.1.60 {ECO:0000255|HAMAP-Rule:MF_02032, ECO:0000269|PubMed:9772162} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.60 {ECO:0000255|HAMAP-Rule:MF_02032, ECO:0000269|PubMed:9772162} InterPro IPR002204 http://www.ebi.ac.uk/interpro/entry/IPR002204 InterPro IPR006115 http://www.ebi.ac.uk/interpro/entry/IPR006115 InterPro IPR006398 http://www.ebi.ac.uk/interpro/entry/IPR006398 InterPro IPR008927 http://www.ebi.ac.uk/interpro/entry/IPR008927 InterPro IPR013328 http://www.ebi.ac.uk/interpro/entry/IPR013328 InterPro IPR015815 http://www.ebi.ac.uk/interpro/entry/IPR015815 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR029154 http://www.ebi.ac.uk/interpro/entry/IPR029154 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5526 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5526 KEGG_Gene eco:b3125 http://www.genome.jp/dbget-bin/www_bget?eco:b3125 KEGG_Orthology KO:K00042 http://www.genome.jp/dbget-bin/www_bget?KO:K00042 KEGG_Pathway ko00630 http://www.genome.jp/kegg-bin/show_pathway?ko00630 KEGG_Reaction rn:R01745 http://www.genome.jp/dbget-bin/www_bget?rn:R01745 KEGG_Reaction rn:R01747 http://www.genome.jp/dbget-bin/www_bget?rn:R01747 OMA ASREVHD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ASREVHD PROSITE PS00895 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00895 PSORT swissprot:GARR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GARR_ECOLI PSORT-B swissprot:GARR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GARR_ECOLI PSORT2 swissprot:GARR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GARR_ECOLI Pfam PF03446 http://pfam.xfam.org/family/PF03446 Pfam PF14833 http://pfam.xfam.org/family/PF14833 Phobius swissprot:GARR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GARR_ECOLI PhylomeDB P0ABQ2 http://phylomedb.org/?seqid=P0ABQ2 ProteinModelPortal P0ABQ2 http://www.proteinmodelportal.org/query/uniprot/P0ABQ2 PubMed 10762278 http://www.ncbi.nlm.nih.gov/pubmed/10762278 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1705543 http://www.ncbi.nlm.nih.gov/pubmed/1705543 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9772162 http://www.ncbi.nlm.nih.gov/pubmed/9772162 RefSeq NP_417594 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417594 SMR P0ABQ2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABQ2 STRING 511145.b3125 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3125&targetmode=cogs STRING COG2084 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2084&targetmode=cogs SUPFAM SSF48179 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48179 SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 TIGRFAMs TIGR01505 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01505 UniProtKB GARR_ECOLI http://www.uniprot.org/uniprot/GARR_ECOLI UniProtKB-AC P0ABQ2 http://www.uniprot.org/uniprot/P0ABQ2 charge swissprot:GARR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GARR_ECOLI eggNOG COG2084 http://eggnogapi.embl.de/nog_data/html/tree/COG2084 eggNOG ENOG4105CF3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CF3 epestfind swissprot:GARR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GARR_ECOLI garnier swissprot:GARR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GARR_ECOLI helixturnhelix swissprot:GARR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GARR_ECOLI hmoment swissprot:GARR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GARR_ECOLI iep swissprot:GARR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GARR_ECOLI inforesidue swissprot:GARR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GARR_ECOLI octanol swissprot:GARR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GARR_ECOLI pepcoil swissprot:GARR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GARR_ECOLI pepdigest swissprot:GARR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GARR_ECOLI pepinfo swissprot:GARR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GARR_ECOLI pepnet swissprot:GARR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GARR_ECOLI pepstats swissprot:GARR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GARR_ECOLI pepwheel swissprot:GARR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GARR_ECOLI pepwindow swissprot:GARR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GARR_ECOLI sigcleave swissprot:GARR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GARR_ECOLI ## Database ID URL or Descriptions # AltName MUTT_ECOLI 7,8-dihydro-8-oxoguanine-triphosphatase # AltName MUTT_ECOLI Mutator protein MutT # AltName MUTT_ECOLI dGTP pyrophosphohydrolase # BIOPHYSICOCHEMICAL PROPERTIES MUTT_ECOLI Kinetic parameters KM=0.058 uM for 8-oxo-dGDP {ECO 0000269|PubMed 15850400}; KM=170 uM for dGDP {ECO 0000269|PubMed 15850400}; KM=0.081 uM for 8-oxo-dGTP {ECO 0000269|PubMed 15850400}; KM=1100 uM for GTP {ECO 0000269|PubMed 15850400}; KM=0.045 uM for 8-oxo-GDP {ECO 0000269|PubMed 15850400}; KM=0.26 uM for 8-oxo-GTP {ECO 0000269|PubMed 15850400}; Vmax=3.7 pmol/min/ng enzyme toward 8-oxo-dGDP {ECO 0000269|PubMed 15850400}; Vmax=5.9 pmol/min/ng enzyme toward dGDP {ECO 0000269|PubMed 15850400}; Vmax=20 pmol/min/ng enzyme toward 8-oxo-dGTP {ECO 0000269|PubMed 15850400}; Vmax=44 pmol/min/ng enzyme toward GTP {ECO 0000269|PubMed 15850400}; Vmax=4.8 pmol/min/ng enzyme toward 8-oxo-GDP {ECO 0000269|PubMed 15850400}; Vmax=22 pmol/min/ng enzyme toward 8-oxo-GTP {ECO 0000269|PubMed 15850400}; # BRENDA 3.6.1.55 2026 # BioGrid 4261888 366 # CATALYTIC ACTIVITY 8-oxo-dGTP + H(2)O = 8-oxo-dGMP + diphosphate. {ECO:0000269|PubMed 15850400}. # COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI 18420; Note=Binds 1 Mg(2+) ion per subunit.; # EcoGene EG10626 mutT # FUNCTION MUTT_ECOLI Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus leading to A.T to G.C transversions. MutT specifically degrades 8-oxo-dGTP to the monophosphate. {ECO 0000269|PubMed 1309939, ECO 0000269|PubMed 15850400}. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0008413 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity; IDA:UniProtKB. # GO_function GO:0030145 manganese ion binding; IDA:EcoCyc. # GO_function GO:0035539 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity; IDA:EcoCyc. # GO_function GO:0044715 8-oxo-dGDP phosphatase activity; IDA:EcoCyc. # GO_function GO:0044716 8-oxo-GDP phosphatase activity; IDA:EcoCyc. # GO_process GO:0006260 DNA replication; IEA:UniProtKB-KW. # GO_process GO:0006281 DNA repair; IC:UniProtKB. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.90.79.10 -; 1. # INTERACTION MUTT_ECOLI P0AC47 frdB; NbExp=4; IntAct=EBI-1121389, EBI-906724; # IntAct P08337 5 # InterPro IPR000086 NUDIX_hydrolase_dom # InterPro IPR003561 Mutator_MutT # InterPro IPR015797 NUDIX_hydrolase_dom-like # InterPro IPR020084 NUDIX_hydrolase_CS # InterPro IPR020476 Nudix_hydrolase # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # Organism MUTT_ECOLI Escherichia coli (strain K12) # PANTHER PTHR22769:SF36 PTHR22769:SF36 # PATRIC 32115303 VBIEscCol129921_0103 # PDB 1MUT NMR; -; A=1-129 # PDB 1PPX NMR; -; A=1-129 # PDB 1PUN NMR; -; A=1-129 # PDB 1PUQ NMR; -; A=1-129 # PDB 1PUS NMR; -; A=1-129 # PDB 1TUM NMR; -; A=1-129 # PDB 3A6S X-ray; 1.80 A; A/B=1-129 # PDB 3A6T X-ray; 1.96 A; A=1-129 # PDB 3A6U X-ray; 2.56 A; A=1-129 # PDB 3A6V X-ray; 2.00 A; A/B=1-129 # PIR A27890 MVECMT # PRINTS PR00502 NUDIXFAMILY # PRINTS PR01401 MUTATORMUTT # PROSITE PS00893 NUDIX_BOX # PROSITE PS51462 NUDIX # Pfam PF00293 NUDIX # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MUTT_ECOLI 8-oxo-dGTP diphosphatase # RefSeq NP_414641 NC_000913.3 # RefSeq WP_000736007 NZ_LN832404.1 # SIMILARITY Belongs to the Nudix hydrolase family. {ECO 0000305}. # SIMILARITY Contains 1 nudix hydrolase domain. {ECO:0000255|PROSITE-ProRule PRU00794}. # SUBUNIT Monomer. {ECO:0000269|PubMed 9063868}. # SUPFAM SSF55811 SSF55811 # TIGRFAMs TIGR00586 mutt # eggNOG COG0494 LUCA # eggNOG ENOG4105M6F Bacteria BLAST swissprot:MUTT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MUTT_ECOLI BioCyc ECOL316407:JW0097-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0097-MONOMER BioCyc EcoCyc:EG10626-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10626-MONOMER BioCyc MetaCyc:EG10626-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10626-MONOMER COG COG0494 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0494 DIP DIP-10288N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10288N DOI 10.1007/BF00326530 http://dx.doi.org/10.1007/BF00326530 DOI 10.1021/bi00046a006 http://dx.doi.org/10.1021/bi00046a006 DOI 10.1021/bi047550k http://dx.doi.org/10.1021/bi047550k DOI 10.1021/bi962619c http://dx.doi.org/10.1021/bi962619c DOI 10.1038/355273a0 http://dx.doi.org/10.1038/355273a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M109.066373 http://dx.doi.org/10.1074/jbc.M109.066373 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.1.55 http://www.genome.jp/dbget-bin/www_bget?EC:3.6.1.55 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M20791 http://www.ebi.ac.uk/ena/data/view/M20791 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X04831 http://www.ebi.ac.uk/ena/data/view/X04831 EMBL X55034 http://www.ebi.ac.uk/ena/data/view/X55034 ENZYME 3.6.1.55 http://enzyme.expasy.org/EC/3.6.1.55 EchoBASE EB0621 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0621 EcoGene EG10626 http://www.ecogene.org/geneInfo.php?eg_id=EG10626 EnsemblBacteria AAC73210 http://www.ensemblgenomes.org/id/AAC73210 EnsemblBacteria AAC73210 http://www.ensemblgenomes.org/id/AAC73210 EnsemblBacteria BAB96667 http://www.ensemblgenomes.org/id/BAB96667 EnsemblBacteria BAB96667 http://www.ensemblgenomes.org/id/BAB96667 EnsemblBacteria BAB96667 http://www.ensemblgenomes.org/id/BAB96667 EnsemblBacteria b0099 http://www.ensemblgenomes.org/id/b0099 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0008413 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008413 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_function GO:0035539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035539 GO_function GO:0044715 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044715 GO_function GO:0044716 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044716 GO_process GO:0006260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260 GO_process GO:0006281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006281 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.90.79.10 http://www.cathdb.info/version/latest/superfamily/3.90.79.10 GeneID 944824 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944824 HOGENOM HOG000261967 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261967&db=HOGENOM6 InParanoid P08337 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P08337 IntAct P08337 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P08337* IntEnz 3.6.1.55 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.1.55 InterPro IPR000086 http://www.ebi.ac.uk/interpro/entry/IPR000086 InterPro IPR003561 http://www.ebi.ac.uk/interpro/entry/IPR003561 InterPro IPR015797 http://www.ebi.ac.uk/interpro/entry/IPR015797 InterPro IPR020084 http://www.ebi.ac.uk/interpro/entry/IPR020084 InterPro IPR020476 http://www.ebi.ac.uk/interpro/entry/IPR020476 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW0097 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0097 KEGG_Gene eco:b0099 http://www.genome.jp/dbget-bin/www_bget?eco:b0099 KEGG_Orthology KO:K03574 http://www.genome.jp/dbget-bin/www_bget?KO:K03574 MINT MINT-1239561 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1239561 OMA RLHWCKV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RLHWCKV PANTHER PTHR22769:SF36 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22769:SF36 PDB 1MUT http://www.ebi.ac.uk/pdbe-srv/view/entry/1MUT PDB 1PPX http://www.ebi.ac.uk/pdbe-srv/view/entry/1PPX PDB 1PUN http://www.ebi.ac.uk/pdbe-srv/view/entry/1PUN PDB 1PUQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1PUQ PDB 1PUS http://www.ebi.ac.uk/pdbe-srv/view/entry/1PUS PDB 1TUM http://www.ebi.ac.uk/pdbe-srv/view/entry/1TUM PDB 3A6S http://www.ebi.ac.uk/pdbe-srv/view/entry/3A6S PDB 3A6T http://www.ebi.ac.uk/pdbe-srv/view/entry/3A6T PDB 3A6U http://www.ebi.ac.uk/pdbe-srv/view/entry/3A6U PDB 3A6V http://www.ebi.ac.uk/pdbe-srv/view/entry/3A6V PDBsum 1MUT http://www.ebi.ac.uk/pdbsum/1MUT PDBsum 1PPX http://www.ebi.ac.uk/pdbsum/1PPX PDBsum 1PUN http://www.ebi.ac.uk/pdbsum/1PUN PDBsum 1PUQ http://www.ebi.ac.uk/pdbsum/1PUQ PDBsum 1PUS http://www.ebi.ac.uk/pdbsum/1PUS PDBsum 1TUM http://www.ebi.ac.uk/pdbsum/1TUM PDBsum 3A6S http://www.ebi.ac.uk/pdbsum/3A6S PDBsum 3A6T http://www.ebi.ac.uk/pdbsum/3A6T PDBsum 3A6U http://www.ebi.ac.uk/pdbsum/3A6U PDBsum 3A6V http://www.ebi.ac.uk/pdbsum/3A6V PRINTS PR00502 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00502 PRINTS PR01401 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01401 PROSITE PS00893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00893 PROSITE PS51462 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51462 PSORT swissprot:MUTT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MUTT_ECOLI PSORT-B swissprot:MUTT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MUTT_ECOLI PSORT2 swissprot:MUTT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MUTT_ECOLI Pfam PF00293 http://pfam.xfam.org/family/PF00293 Phobius swissprot:MUTT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MUTT_ECOLI PhylomeDB P08337 http://phylomedb.org/?seqid=P08337 ProteinModelPortal P08337 http://www.proteinmodelportal.org/query/uniprot/P08337 PubMed 1309939 http://www.ncbi.nlm.nih.gov/pubmed/1309939 PubMed 15850400 http://www.ncbi.nlm.nih.gov/pubmed/15850400 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1851162 http://www.ncbi.nlm.nih.gov/pubmed/1851162 PubMed 19864691 http://www.ncbi.nlm.nih.gov/pubmed/19864691 PubMed 2841285 http://www.ncbi.nlm.nih.gov/pubmed/2841285 PubMed 3033442 http://www.ncbi.nlm.nih.gov/pubmed/3033442 PubMed 3288626 http://www.ncbi.nlm.nih.gov/pubmed/3288626 PubMed 7578113 http://www.ncbi.nlm.nih.gov/pubmed/7578113 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9063868 http://www.ncbi.nlm.nih.gov/pubmed/9063868 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414641 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414641 RefSeq WP_000736007 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000736007 SMR P08337 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P08337 STRING 511145.b0099 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0099&targetmode=cogs STRING COG0494 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0494&targetmode=cogs SUPFAM SSF55811 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55811 TIGRFAMs TIGR00586 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00586 UniProtKB MUTT_ECOLI http://www.uniprot.org/uniprot/MUTT_ECOLI UniProtKB-AC P08337 http://www.uniprot.org/uniprot/P08337 charge swissprot:MUTT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MUTT_ECOLI eggNOG COG0494 http://eggnogapi.embl.de/nog_data/html/tree/COG0494 eggNOG ENOG4105M6F http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105M6F epestfind swissprot:MUTT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MUTT_ECOLI garnier swissprot:MUTT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MUTT_ECOLI helixturnhelix swissprot:MUTT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MUTT_ECOLI hmoment swissprot:MUTT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MUTT_ECOLI iep swissprot:MUTT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MUTT_ECOLI inforesidue swissprot:MUTT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MUTT_ECOLI octanol swissprot:MUTT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MUTT_ECOLI pepcoil swissprot:MUTT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MUTT_ECOLI pepdigest swissprot:MUTT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MUTT_ECOLI pepinfo swissprot:MUTT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MUTT_ECOLI pepnet swissprot:MUTT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MUTT_ECOLI pepstats swissprot:MUTT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MUTT_ECOLI pepwheel swissprot:MUTT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MUTT_ECOLI pepwindow swissprot:MUTT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MUTT_ECOLI sigcleave swissprot:MUTT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MUTT_ECOLI ## Database ID URL or Descriptions # AltName RECO_ECOLI Recombination protein O # BioGrid 4259430 175 # DISRUPTION PHENOTYPE No visible phenotype. {ECO:0000269|PubMed 2540151}. # EcoGene EG10832 recO # FUNCTION RECO_ECOLI Involved in DNA repair and RecF pathway recombination. # GO_process GO:0006281 DNA repair; IEA:UniProtKB-HAMAP. # GO_process GO:0006310 DNA recombination; IEA:UniProtKB-HAMAP. # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # HAMAP MF_00201 RecO # INDUCTION RECO_ECOLI Encoded in the rnc-era-recO operon. # IntAct P0A7H3 8 # InterPro IPR003717 RecO # InterPro IPR012340 NA-bd_OB-fold # InterPro IPR022572 DNA_rep/recomb_RecO_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko03440 Homologous recombination # Organism RECO_ECOLI Escherichia coli (strain K12) # PATRIC 32120529 VBIEscCol129921_2667 # PDB 3Q8D X-ray; 2.30 A; A/B=1-242 # PIR JS0116 BVECRO # Pfam PF02565 RecO_C # Pfam PF11967 RecO_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RECO_ECOLI DNA repair protein RecO # RefSeq NP_417060 NC_000913.3 # RefSeq WP_000399404 NZ_LN832404.1 # SIMILARITY Belongs to the RecO family. {ECO 0000305}. # SUBUNIT Monomer. {ECO:0000269|PubMed 8107098}. # SUPFAM SSF50249 SSF50249 # TIGRFAMs TIGR00613 reco # eggNOG COG1381 LUCA # eggNOG ENOG41071DT Bacteria BLAST swissprot:RECO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RECO_ECOLI BioCyc ECOL316407:JW2549-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2549-MONOMER BioCyc EcoCyc:EG10832-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10832-MONOMER BioCyc MetaCyc:EG10832-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10832-MONOMER COG COG1381 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1381 DIP DIP-48093N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48093N DOI 10.1006/jmbi.1994.1123 http://dx.doi.org/10.1006/jmbi.1994.1123 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D64044 http://www.ebi.ac.uk/ena/data/view/D64044 EMBL M26416 http://www.ebi.ac.uk/ena/data/view/M26416 EMBL M27251 http://www.ebi.ac.uk/ena/data/view/M27251 EMBL M74526 http://www.ebi.ac.uk/ena/data/view/M74526 EMBL M76470 http://www.ebi.ac.uk/ena/data/view/M76470 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36841 http://www.ebi.ac.uk/ena/data/view/U36841 EchoBASE EB0825 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0825 EcoGene EG10832 http://www.ecogene.org/geneInfo.php?eg_id=EG10832 EnsemblBacteria AAC75618 http://www.ensemblgenomes.org/id/AAC75618 EnsemblBacteria AAC75618 http://www.ensemblgenomes.org/id/AAC75618 EnsemblBacteria BAE76741 http://www.ensemblgenomes.org/id/BAE76741 EnsemblBacteria BAE76741 http://www.ensemblgenomes.org/id/BAE76741 EnsemblBacteria BAE76741 http://www.ensemblgenomes.org/id/BAE76741 EnsemblBacteria b2565 http://www.ensemblgenomes.org/id/b2565 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006281 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 947038 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947038 HAMAP MF_00201 http://hamap.expasy.org/unirule/MF_00201 HOGENOM HOG000245560 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000245560&db=HOGENOM6 InParanoid P0A7H3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7H3 IntAct P0A7H3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7H3* InterPro IPR003717 http://www.ebi.ac.uk/interpro/entry/IPR003717 InterPro IPR012340 http://www.ebi.ac.uk/interpro/entry/IPR012340 InterPro IPR022572 http://www.ebi.ac.uk/interpro/entry/IPR022572 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW2549 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2549 KEGG_Gene eco:b2565 http://www.genome.jp/dbget-bin/www_bget?eco:b2565 KEGG_Orthology KO:K03584 http://www.genome.jp/dbget-bin/www_bget?KO:K03584 KEGG_Pathway ko03440 http://www.genome.jp/kegg-bin/show_pathway?ko03440 OMA YVLHSRA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YVLHSRA PDB 3Q8D http://www.ebi.ac.uk/pdbe-srv/view/entry/3Q8D PDBsum 3Q8D http://www.ebi.ac.uk/pdbsum/3Q8D PSORT swissprot:RECO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RECO_ECOLI PSORT-B swissprot:RECO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RECO_ECOLI PSORT2 swissprot:RECO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RECO_ECOLI Pfam PF02565 http://pfam.xfam.org/family/PF02565 Pfam PF11967 http://pfam.xfam.org/family/PF11967 Phobius swissprot:RECO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RECO_ECOLI PhylomeDB P0A7H3 http://phylomedb.org/?seqid=P0A7H3 ProteinModelPortal P0A7H3 http://www.proteinmodelportal.org/query/uniprot/P0A7H3 PubMed 1537800 http://www.ncbi.nlm.nih.gov/pubmed/1537800 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2540151 http://www.ncbi.nlm.nih.gov/pubmed/2540151 PubMed 2544549 http://www.ncbi.nlm.nih.gov/pubmed/2544549 PubMed 8107098 http://www.ncbi.nlm.nih.gov/pubmed/8107098 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417060 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417060 RefSeq WP_000399404 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000399404 SMR P0A7H3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7H3 STRING 511145.b2565 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2565&targetmode=cogs STRING COG1381 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1381&targetmode=cogs SUPFAM SSF50249 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50249 TIGRFAMs TIGR00613 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00613 UniProtKB RECO_ECOLI http://www.uniprot.org/uniprot/RECO_ECOLI UniProtKB-AC P0A7H3 http://www.uniprot.org/uniprot/P0A7H3 charge swissprot:RECO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RECO_ECOLI eggNOG COG1381 http://eggnogapi.embl.de/nog_data/html/tree/COG1381 eggNOG ENOG41071DT http://eggnogapi.embl.de/nog_data/html/tree/ENOG41071DT epestfind swissprot:RECO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RECO_ECOLI garnier swissprot:RECO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RECO_ECOLI helixturnhelix swissprot:RECO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RECO_ECOLI hmoment swissprot:RECO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RECO_ECOLI iep swissprot:RECO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RECO_ECOLI inforesidue swissprot:RECO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RECO_ECOLI octanol swissprot:RECO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RECO_ECOLI pepcoil swissprot:RECO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RECO_ECOLI pepdigest swissprot:RECO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RECO_ECOLI pepinfo swissprot:RECO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RECO_ECOLI pepnet swissprot:RECO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RECO_ECOLI pepstats swissprot:RECO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RECO_ECOLI pepwheel swissprot:RECO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RECO_ECOLI pepwindow swissprot:RECO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RECO_ECOLI sigcleave swissprot:RECO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RECO_ECOLI ## Database ID URL or Descriptions # AltName XYLE_ECOLI D-xylose transporter # BioGrid 4262660 7 # CDD cd06174 MFS # EcoGene EG11076 xylE # FUNCTION XYLE_ECOLI Uptake of D-xylose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Glucose is not transported, but can compete for xylose binding sites and can inhibit xylose transport (in vitro). {ECO 0000269|PubMed 23075985}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_function XYLE_ECOLI GO 0015519 D-xylose proton symporter activity; IDA EcoCyc. # GO_process GO:0015753 D-xylose transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # INDUCTION XYLE_ECOLI By xylose. # InterPro IPR003663 Sugar/inositol_transpt # InterPro IPR005828 MFS_sugar_transport-like # InterPro IPR005829 Sugar_transporter_CS # InterPro IPR020846 MFS_dom # KEGG_Brite ko02000 Transporters # MISCELLANEOUS E.coli has two D-xylose transport systems that accumulate sugar against a concentration gradient the XylE system which utilizes the electrochemical gradient of protons and that is insensitive to cold osmotic shock and the XylF system that uses a high-energy phosphate compound and is sensitive to cold osmotic shock. # Organism XYLE_ECOLI Escherichia coli (strain K12) # PATRIC 32123595 VBIEscCol129921_4146 # PDB 4GBY X-ray; 2.81 A; A=1-491 # PDB 4GBZ X-ray; 2.89 A; A=1-491 # PDB 4GC0 X-ray; 2.60 A; A=1-491 # PDB 4JA3 X-ray; 3.80 A; A/B=2-485 # PDB 4JA4 X-ray; 4.20 A; A/B/C=2-485 # PDB 4QIQ X-ray; 3.51 A; A=6-480 # PIR A26430 A26430 # PRINTS PR00171 SUGRTRNSPORT # PROSITE PS00216 SUGAR_TRANSPORT_1 # PROSITE PS00217 SUGAR_TRANSPORT_2 # PROSITE PS50850 MFS # Pfam PF00083 Sugar_tr # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName XYLE_ECOLI D-xylose-proton symporter # RefSeq NP_418455 NC_000913.3 # RefSeq WP_001097274 NZ_LN832404.1 # SIMILARITY Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. {ECO 0000305}. # SUBCELLULAR LOCATION XYLE_ECOLI Cell inner membrane {ECO 0000269|PubMed 23075985}; Multi-pass membrane protein {ECO 0000269|PubMed 23075985}. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.1 the major facilitator superfamily (mfs) # TIGRFAMs TIGR00879 SP # eggNOG ENOG4107QNK Bacteria # eggNOG ENOG410XNQK LUCA BLAST swissprot:XYLE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:XYLE_ECOLI BioCyc ECOL316407:JW3991-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3991-MONOMER BioCyc EcoCyc:XYLE-MONOMER http://biocyc.org/getid?id=EcoCyc:XYLE-MONOMER BioCyc MetaCyc:XYLE-MONOMER http://biocyc.org/getid?id=MetaCyc:XYLE-MONOMER COG COG0477 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0477 DOI 10.1038/325641a0 http://dx.doi.org/10.1038/325641a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature11524 http://dx.doi.org/10.1038/nature11524 DOI 10.1038/nsmb.2569 http://dx.doi.org/10.1038/nsmb.2569 DOI 10.1093/nar/16.9.4097 http://dx.doi.org/10.1093/nar/16.9.4097 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J02812 http://www.ebi.ac.uk/ena/data/view/J02812 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X06663 http://www.ebi.ac.uk/ena/data/view/X06663 EchoBASE EB1069 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1069 EcoGene EG11076 http://www.ecogene.org/geneInfo.php?eg_id=EG11076 EnsemblBacteria AAC77001 http://www.ensemblgenomes.org/id/AAC77001 EnsemblBacteria AAC77001 http://www.ensemblgenomes.org/id/AAC77001 EnsemblBacteria BAE78033 http://www.ensemblgenomes.org/id/BAE78033 EnsemblBacteria BAE78033 http://www.ensemblgenomes.org/id/BAE78033 EnsemblBacteria BAE78033 http://www.ensemblgenomes.org/id/BAE78033 EnsemblBacteria b4031 http://www.ensemblgenomes.org/id/b4031 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015519 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015519 GO_process GO:0015753 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015753 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948529 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948529 HOGENOM HOG000202868 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000202868&db=HOGENOM6 InParanoid P0AGF4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGF4 InterPro IPR003663 http://www.ebi.ac.uk/interpro/entry/IPR003663 InterPro IPR005828 http://www.ebi.ac.uk/interpro/entry/IPR005828 InterPro IPR005829 http://www.ebi.ac.uk/interpro/entry/IPR005829 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3991 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3991 KEGG_Gene eco:b4031 http://www.genome.jp/dbget-bin/www_bget?eco:b4031 KEGG_Orthology KO:K08138 http://www.genome.jp/dbget-bin/www_bget?KO:K08138 OMA WTSNFAI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WTSNFAI PDB 4GBY http://www.ebi.ac.uk/pdbe-srv/view/entry/4GBY PDB 4GBZ http://www.ebi.ac.uk/pdbe-srv/view/entry/4GBZ PDB 4GC0 http://www.ebi.ac.uk/pdbe-srv/view/entry/4GC0 PDB 4JA3 http://www.ebi.ac.uk/pdbe-srv/view/entry/4JA3 PDB 4JA4 http://www.ebi.ac.uk/pdbe-srv/view/entry/4JA4 PDB 4QIQ http://www.ebi.ac.uk/pdbe-srv/view/entry/4QIQ PDBsum 4GBY http://www.ebi.ac.uk/pdbsum/4GBY PDBsum 4GBZ http://www.ebi.ac.uk/pdbsum/4GBZ PDBsum 4GC0 http://www.ebi.ac.uk/pdbsum/4GC0 PDBsum 4JA3 http://www.ebi.ac.uk/pdbsum/4JA3 PDBsum 4JA4 http://www.ebi.ac.uk/pdbsum/4JA4 PDBsum 4QIQ http://www.ebi.ac.uk/pdbsum/4QIQ PRINTS PR00171 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00171 PROSITE PS00216 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00216 PROSITE PS00217 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00217 PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:XYLE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:XYLE_ECOLI PSORT-B swissprot:XYLE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:XYLE_ECOLI PSORT2 swissprot:XYLE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:XYLE_ECOLI Pfam PF00083 http://pfam.xfam.org/family/PF00083 Phobius swissprot:XYLE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:XYLE_ECOLI PhylomeDB P0AGF4 http://phylomedb.org/?seqid=P0AGF4 ProteinModelPortal P0AGF4 http://www.proteinmodelportal.org/query/uniprot/P0AGF4 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 23075985 http://www.ncbi.nlm.nih.gov/pubmed/23075985 PubMed 23624861 http://www.ncbi.nlm.nih.gov/pubmed/23624861 PubMed 2820984 http://www.ncbi.nlm.nih.gov/pubmed/2820984 PubMed 2836810 http://www.ncbi.nlm.nih.gov/pubmed/2836810 PubMed 3543693 http://www.ncbi.nlm.nih.gov/pubmed/3543693 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418455 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418455 RefSeq WP_001097274 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001097274 SMR P0AGF4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AGF4 STRING 511145.b4031 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4031&targetmode=cogs STRING COG0477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0477&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.1 http://www.tcdb.org/search/result.php?tc=2.A.1.1 TIGRFAMs TIGR00879 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00879 UniProtKB XYLE_ECOLI http://www.uniprot.org/uniprot/XYLE_ECOLI UniProtKB-AC P0AGF4 http://www.uniprot.org/uniprot/P0AGF4 charge swissprot:XYLE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:XYLE_ECOLI eggNOG ENOG4107QNK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QNK eggNOG ENOG410XNQK http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNQK epestfind swissprot:XYLE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:XYLE_ECOLI garnier swissprot:XYLE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:XYLE_ECOLI helixturnhelix swissprot:XYLE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:XYLE_ECOLI hmoment swissprot:XYLE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:XYLE_ECOLI iep swissprot:XYLE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:XYLE_ECOLI inforesidue swissprot:XYLE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:XYLE_ECOLI octanol swissprot:XYLE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:XYLE_ECOLI pepcoil swissprot:XYLE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:XYLE_ECOLI pepdigest swissprot:XYLE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:XYLE_ECOLI pepinfo swissprot:XYLE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:XYLE_ECOLI pepnet swissprot:XYLE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:XYLE_ECOLI pepstats swissprot:XYLE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:XYLE_ECOLI pepwheel swissprot:XYLE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:XYLE_ECOLI pepwindow swissprot:XYLE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:XYLE_ECOLI sigcleave swissprot:XYLE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:XYLE_ECOLI ## Database ID URL or Descriptions # BioGrid 4262208 6 # EcoGene EG11563 fixB # FUNCTION FIXB_ECOLI Required for anaerobic carnitine reduction. May bring reductant to CaiA. {ECO 0000269|PubMed 12081978}. # GO_function GO:0000062 fatty-acyl-CoA binding; IBA:GO_Central. # GO_function GO:0003995 acyl-CoA dehydrogenase activity; IBA:GO_Central. # GO_function GO:0009055 electron carrier activity; IBA:GO_Central. # GO_function GO:0016491 oxidoreductase activity; IBA:GO_Central. # GO_function GO:0050660 flavin adenine dinucleotide binding; IBA:GO_Central. # GO_function GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor; IBA:GO_Central. # GO_process GO:0009437 carnitine metabolic process; IMP:EcoliWiki. # GO_process GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase; IBA:GO_Central. # GO_process GO:0055088 lipid homeostasis; IBA:GO_Central. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0042592 homeostatic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.1220 -; 1. # Gene3D 3.40.50.620 -; 1. # HAMAP MF_01056 FixB # INTERACTION FIXB_ECOLI P0AES0 gss; NbExp=2; IntAct=EBI-554030, EBI-557080; # IntAct P31574 12 # InterPro IPR001308 ETF_a/FixB # InterPro IPR014729 Rossmann-like_a/b/a_fold # InterPro IPR014730 ETF_a/b_N # InterPro IPR014731 ETF_asu_C # InterPro IPR018206 ETF_asu_C_CS # InterPro IPR023461 FixB # InterPro IPR029035 DHS-like_NAD/FAD-binding_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko00910 Nitrogen metabolism # Organism FIXB_ECOLI Escherichia coli (strain K12) # PATHWAY FIXB_ECOLI Amine and polyamine metabolism; carnitine metabolism. # PATRIC 32115183 VBIEscCol129921_0043 # PIR B64725 B64725 # PIRSF PIRSF000089 Electra_flavoP_a # PROSITE PS00696 ETF_ALPHA # Pfam PF00766 ETF_alpha # Pfam PF01012 ETF # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FIXB_ECOLI Protein FixB # RefSeq NP_414584 NC_000913.3 # RefSeq WP_001091499 NZ_LN832404.1 # SIMILARITY Belongs to the ETF alpha-subunit/FixB family. {ECO 0000305}. # SMART SM00893 ETF # SUBUNIT Heterodimer of FixA and FixB. {ECO 0000305}. # SUPFAM SSF52467 SSF52467 # eggNOG COG2025 LUCA # eggNOG ENOG4105C10 Bacteria BLAST swissprot:FIXB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FIXB_ECOLI BioCyc ECOL316407:JW0041-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0041-MONOMER BioCyc EcoCyc:EG11563-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11563-MONOMER COG COG2025 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2025 DIP DIP-9621N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9621N DOI 10.1002/jobm.3620350404 http://dx.doi.org/10.1002/jobm.3620350404 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.14.4044-4047.2002 http://dx.doi.org/10.1128/JB.184.14.4044-4047.2002 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X71977 http://www.ebi.ac.uk/ena/data/view/X71977 EchoBASE EB1524 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1524 EcoGene EG11563 http://www.ecogene.org/geneInfo.php?eg_id=EG11563 EnsemblBacteria AAC73153 http://www.ensemblgenomes.org/id/AAC73153 EnsemblBacteria AAC73153 http://www.ensemblgenomes.org/id/AAC73153 EnsemblBacteria BAE76037 http://www.ensemblgenomes.org/id/BAE76037 EnsemblBacteria BAE76037 http://www.ensemblgenomes.org/id/BAE76037 EnsemblBacteria BAE76037 http://www.ensemblgenomes.org/id/BAE76037 EnsemblBacteria b0042 http://www.ensemblgenomes.org/id/b0042 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000062 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000062 GO_function GO:0003995 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003995 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_function GO:0052890 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052890 GO_process GO:0009437 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009437 GO_process GO:0033539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033539 GO_process GO:0055088 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055088 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.1220 http://www.cathdb.info/version/latest/superfamily/3.40.50.1220 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 GeneID 948939 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948939 HAMAP MF_01056 http://hamap.expasy.org/unirule/MF_01056 HOGENOM HOG000247866 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000247866&db=HOGENOM6 InParanoid P31574 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31574 IntAct P31574 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31574* InterPro IPR001308 http://www.ebi.ac.uk/interpro/entry/IPR001308 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 InterPro IPR014730 http://www.ebi.ac.uk/interpro/entry/IPR014730 InterPro IPR014731 http://www.ebi.ac.uk/interpro/entry/IPR014731 InterPro IPR018206 http://www.ebi.ac.uk/interpro/entry/IPR018206 InterPro IPR023461 http://www.ebi.ac.uk/interpro/entry/IPR023461 InterPro IPR029035 http://www.ebi.ac.uk/interpro/entry/IPR029035 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW0041 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0041 KEGG_Gene eco:b0042 http://www.genome.jp/dbget-bin/www_bget?eco:b0042 KEGG_Orthology KO:K03522 http://www.genome.jp/dbget-bin/www_bget?KO:K03522 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 MINT MINT-1240082 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1240082 OMA MIEEMAD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MIEEMAD PROSITE PS00696 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00696 PSORT swissprot:FIXB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FIXB_ECOLI PSORT-B swissprot:FIXB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FIXB_ECOLI PSORT2 swissprot:FIXB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FIXB_ECOLI Pfam PF00766 http://pfam.xfam.org/family/PF00766 Pfam PF01012 http://pfam.xfam.org/family/PF01012 Phobius swissprot:FIXB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FIXB_ECOLI PhylomeDB P31574 http://phylomedb.org/?seqid=P31574 ProteinModelPortal P31574 http://www.proteinmodelportal.org/query/uniprot/P31574 PubMed 12081978 http://www.ncbi.nlm.nih.gov/pubmed/12081978 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7473063 http://www.ncbi.nlm.nih.gov/pubmed/7473063 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414584 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414584 RefSeq WP_001091499 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001091499 SMART SM00893 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00893 SMR P31574 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31574 STRING 511145.b0042 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0042&targetmode=cogs STRING COG2025 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2025&targetmode=cogs SUPFAM SSF52467 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52467 UniProtKB FIXB_ECOLI http://www.uniprot.org/uniprot/FIXB_ECOLI UniProtKB-AC P31574 http://www.uniprot.org/uniprot/P31574 charge swissprot:FIXB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FIXB_ECOLI eggNOG COG2025 http://eggnogapi.embl.de/nog_data/html/tree/COG2025 eggNOG ENOG4105C10 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C10 epestfind swissprot:FIXB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FIXB_ECOLI garnier swissprot:FIXB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FIXB_ECOLI helixturnhelix swissprot:FIXB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FIXB_ECOLI hmoment swissprot:FIXB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FIXB_ECOLI iep swissprot:FIXB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FIXB_ECOLI inforesidue swissprot:FIXB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FIXB_ECOLI octanol swissprot:FIXB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FIXB_ECOLI pepcoil swissprot:FIXB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FIXB_ECOLI pepdigest swissprot:FIXB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FIXB_ECOLI pepinfo swissprot:FIXB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FIXB_ECOLI pepnet swissprot:FIXB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FIXB_ECOLI pepstats swissprot:FIXB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FIXB_ECOLI pepwheel swissprot:FIXB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FIXB_ECOLI pepwindow swissprot:FIXB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FIXB_ECOLI sigcleave swissprot:FIXB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FIXB_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES YFBT_ECOLI Kinetic parameters KM=1 mM for Fru1P (with magnesium ions as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; KM=1.3 mM for Fru6P (with zinc ions as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; KM=1.6 mM for Glu6P (with cobalt ions as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; KM=2.2 mM for Ribu5P (with zinc ions as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; KM=7 mM for bGlu1P (with zinc ions as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; pH dependence Optimum pH is between 6 and 7.5. {ECO 0000269|PubMed 16990279}; # BioGrid 4262967 8 # CATALYTIC ACTIVITY YFBT_ECOLI Sugar phosphate + H(2)O = sugar + phosphate. # COFACTOR YFBT_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 16990279}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 16990279}; Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000269|PubMed 16990279}; Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 16990279}; Note=Magnesium. Can also use other divalent metal cations as manganese, cobalt or zinc. {ECO 0000269|PubMed 16990279}; # EcoGene EG14104 yfbT # FUNCTION YFBT_ECOLI Catalyzes the dephosphorylation of different sugar phosphates including ribose-5-phosphate (Ribu5P), fructose-1- phosphate (Fru1P), fructose-6-phosphate (Fru6P), glucose-6- phosphate (Glu6P). Selectively hydrolyzes beta-D-glucose-1- phosphate (bGlu1P) and has no activity with the alpha form. {ECO 0000269|PubMed 15808744, ECO 0000269|PubMed 16990279}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0000287 magnesium ion binding; IDA:UniProtKB. # GO_function GO:0030145 manganese ion binding; IDA:UniProtKB. # GO_function GO:0043136 glycerol-3-phosphatase activity; IDA:EcoCyc. # GO_function GO:0050308 sugar-phosphatase activity; IDA:UniProtKB. # GO_function GO:0050897 cobalt ion binding; IDA:UniProtKB. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0043167 ion binding # Gene3D 1.10.150.240 -; 1. # Gene3D 3.40.50.1000 -; 1. # IntAct P77625 2 # InterPro IPR006439 HAD-SF_hydro_IA # InterPro IPR023198 PGP_dom2 # InterPro IPR023214 HAD-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00051 Fructose and mannose metabolism # Organism YFBT_ECOLI Escherichia coli (strain K12) # PATRIC 32119955 VBIEscCol129921_2387 # PIR C65001 C65001 # PRINTS PR00413 HADHALOGNASE # Pfam PF13419 HAD_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFBT_ECOLI Sugar phosphatase YfbT # RefSeq NP_416796 NC_000913.3 # RefSeq WP_001203392 NZ_LN832404.1 # SIMILARITY Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. {ECO 0000305}. # SUPFAM SSF56784 SSF56784 # TIGRFAMs TIGR01509 HAD-SF-IA-v3 # TIGRFAMs TIGR01549 HAD-SF-IA-v1 # eggNOG COG0637 LUCA # eggNOG ENOG4105EVE Bacteria BLAST swissprot:YFBT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFBT_ECOLI BioCyc ECOL316407:JW5376-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5376-MONOMER BioCyc EcoCyc:G7187-MONOMER http://biocyc.org/getid?id=EcoCyc:G7187-MONOMER BioCyc MetaCyc:G7187-MONOMER http://biocyc.org/getid?id=MetaCyc:G7187-MONOMER COG COG0637 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0637 COG COG2045 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2045 DIP DIP-11972N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11972N DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1016/j.fmrre.2004.12.006 http://dx.doi.org/10.1016/j.fmrre.2004.12.006 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M605449200 http://dx.doi.org/10.1074/jbc.M605449200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.3.23 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.23 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.3.23 http://enzyme.expasy.org/EC/3.1.3.23 EchoBASE EB3857 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3857 EcoGene EG14104 http://www.ecogene.org/geneInfo.php?eg_id=EG14104 EnsemblBacteria AAC75353 http://www.ensemblgenomes.org/id/AAC75353 EnsemblBacteria AAC75353 http://www.ensemblgenomes.org/id/AAC75353 EnsemblBacteria BAA16129 http://www.ensemblgenomes.org/id/BAA16129 EnsemblBacteria BAA16129 http://www.ensemblgenomes.org/id/BAA16129 EnsemblBacteria BAA16129 http://www.ensemblgenomes.org/id/BAA16129 EnsemblBacteria b2293 http://www.ensemblgenomes.org/id/b2293 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_function GO:0043136 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043136 GO_function GO:0050308 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050308 GO_function GO:0050897 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050897 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 1.10.150.240 http://www.cathdb.info/version/latest/superfamily/1.10.150.240 Gene3D 3.40.50.1000 http://www.cathdb.info/version/latest/superfamily/3.40.50.1000 GeneID 946777 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946777 HOGENOM HOG000248341 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000248341&db=HOGENOM6 InParanoid P77625 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77625 IntAct P77625 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77625* IntEnz 3.1.3.23 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.23 InterPro IPR006439 http://www.ebi.ac.uk/interpro/entry/IPR006439 InterPro IPR023198 http://www.ebi.ac.uk/interpro/entry/IPR023198 InterPro IPR023214 http://www.ebi.ac.uk/interpro/entry/IPR023214 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5376 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5376 KEGG_Gene eco:b2293 http://www.genome.jp/dbget-bin/www_bget?eco:b2293 KEGG_Orthology KO:K01112 http://www.genome.jp/dbget-bin/www_bget?KO:K01112 KEGG_Pathway ko00051 http://www.genome.jp/kegg-bin/show_pathway?ko00051 KEGG_Reaction rn:R00118 http://www.genome.jp/dbget-bin/www_bget?rn:R00118 KEGG_Reaction rn:R00872 http://www.genome.jp/dbget-bin/www_bget?rn:R00872 KEGG_Reaction rn:R02706 http://www.genome.jp/dbget-bin/www_bget?rn:R02706 MINT MINT-1275778 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1275778 OMA PKENARH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PKENARH PRINTS PR00413 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00413 PSORT swissprot:YFBT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFBT_ECOLI PSORT-B swissprot:YFBT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFBT_ECOLI PSORT2 swissprot:YFBT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFBT_ECOLI Pfam PF13419 http://pfam.xfam.org/family/PF13419 Phobius swissprot:YFBT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFBT_ECOLI PhylomeDB P77625 http://phylomedb.org/?seqid=P77625 ProteinModelPortal P77625 http://www.proteinmodelportal.org/query/uniprot/P77625 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 15808744 http://www.ncbi.nlm.nih.gov/pubmed/15808744 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16990279 http://www.ncbi.nlm.nih.gov/pubmed/16990279 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416796 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416796 RefSeq WP_001203392 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001203392 SMR P77625 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77625 STRING 511145.b2293 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2293&targetmode=cogs STRING COG0637 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0637&targetmode=cogs STRING COG2045 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2045&targetmode=cogs SUPFAM SSF56784 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784 TIGRFAMs TIGR01509 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01509 TIGRFAMs TIGR01549 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01549 UniProtKB YFBT_ECOLI http://www.uniprot.org/uniprot/YFBT_ECOLI UniProtKB-AC P77625 http://www.uniprot.org/uniprot/P77625 charge swissprot:YFBT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFBT_ECOLI eggNOG COG0637 http://eggnogapi.embl.de/nog_data/html/tree/COG0637 eggNOG ENOG4105EVE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EVE epestfind swissprot:YFBT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFBT_ECOLI garnier swissprot:YFBT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFBT_ECOLI helixturnhelix swissprot:YFBT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFBT_ECOLI hmoment swissprot:YFBT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFBT_ECOLI iep swissprot:YFBT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFBT_ECOLI inforesidue swissprot:YFBT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFBT_ECOLI octanol swissprot:YFBT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFBT_ECOLI pepcoil swissprot:YFBT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFBT_ECOLI pepdigest swissprot:YFBT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFBT_ECOLI pepinfo swissprot:YFBT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFBT_ECOLI pepnet swissprot:YFBT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFBT_ECOLI pepstats swissprot:YFBT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFBT_ECOLI pepwheel swissprot:YFBT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFBT_ECOLI pepwindow swissprot:YFBT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFBT_ECOLI sigcleave swissprot:YFBT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFBT_ECOLI ## Database ID URL or Descriptions # BioGrid 4261752 256 # EcoGene EG13758 ydcO # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0042925 benzoate transporter activity; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # InterPro IPR004711 Benzoate_Transporter # KEGG_Brite ko02000 Transporters # Organism YDCO_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30199:SF0 PTHR30199:SF0 # PATRIC 32118156 VBIEscCol129921_1498 # PIR D64895 D64895 # PROSITE PS00041 HTH_ARAC_FAMILY_1 # Pfam PF03594 BenE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDCO_ECOLI Inner membrane protein YdcO # RefSeq NP_415950 NC_000913.3 # RefSeq WP_001236265 NZ_LN832404.1 # SUBCELLULAR LOCATION YDCO_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.46.1:the benzoate h+ symporter (bene) family # TIGRFAMs TIGR00843 benE # eggNOG COG3135 LUCA # eggNOG ENOG4105DKK Bacteria BLAST swissprot:YDCO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDCO_ECOLI BioCyc ECOL316407:JW5229-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5229-MONOMER BioCyc EcoCyc:B1433-MONOMER http://biocyc.org/getid?id=EcoCyc:B1433-MONOMER COG COG3135 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3135 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3521 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3521 EcoGene EG13758 http://www.ecogene.org/geneInfo.php?eg_id=EG13758 EnsemblBacteria AAC74515 http://www.ensemblgenomes.org/id/AAC74515 EnsemblBacteria AAC74515 http://www.ensemblgenomes.org/id/AAC74515 EnsemblBacteria BAA15061 http://www.ensemblgenomes.org/id/BAA15061 EnsemblBacteria BAA15061 http://www.ensemblgenomes.org/id/BAA15061 EnsemblBacteria BAA15061 http://www.ensemblgenomes.org/id/BAA15061 EnsemblBacteria b1433 http://www.ensemblgenomes.org/id/b1433 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0042925 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042925 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GeneID 947247 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947247 HOGENOM HOG000221975 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000221975&db=HOGENOM6 InParanoid P76103 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76103 InterPro IPR004711 http://www.ebi.ac.uk/interpro/entry/IPR004711 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5229 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5229 KEGG_Gene eco:b1433 http://www.genome.jp/dbget-bin/www_bget?eco:b1433 KEGG_Orthology KO:K05782 http://www.genome.jp/dbget-bin/www_bget?KO:K05782 OMA AIVFQAA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AIVFQAA PANTHER PTHR30199:SF0 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30199:SF0 PROSITE PS00041 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00041 PSORT swissprot:YDCO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDCO_ECOLI PSORT-B swissprot:YDCO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDCO_ECOLI PSORT2 swissprot:YDCO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDCO_ECOLI Pfam PF03594 http://pfam.xfam.org/family/PF03594 Phobius swissprot:YDCO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDCO_ECOLI PhylomeDB P76103 http://phylomedb.org/?seqid=P76103 ProteinModelPortal P76103 http://www.proteinmodelportal.org/query/uniprot/P76103 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415950 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415950 RefSeq WP_001236265 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001236265 STRING 511145.b1433 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1433&targetmode=cogs STRING COG3135 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3135&targetmode=cogs TCDB 2.A.46.1 http://www.tcdb.org/search/result.php?tc=2.A.46.1 TIGRFAMs TIGR00843 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00843 UniProtKB YDCO_ECOLI http://www.uniprot.org/uniprot/YDCO_ECOLI UniProtKB-AC P76103 http://www.uniprot.org/uniprot/P76103 charge swissprot:YDCO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDCO_ECOLI eggNOG COG3135 http://eggnogapi.embl.de/nog_data/html/tree/COG3135 eggNOG ENOG4105DKK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DKK epestfind swissprot:YDCO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDCO_ECOLI garnier swissprot:YDCO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDCO_ECOLI helixturnhelix swissprot:YDCO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDCO_ECOLI hmoment swissprot:YDCO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDCO_ECOLI iep swissprot:YDCO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDCO_ECOLI inforesidue swissprot:YDCO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDCO_ECOLI octanol swissprot:YDCO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDCO_ECOLI pepcoil swissprot:YDCO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDCO_ECOLI pepdigest swissprot:YDCO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDCO_ECOLI pepinfo swissprot:YDCO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDCO_ECOLI pepnet swissprot:YDCO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDCO_ECOLI pepstats swissprot:YDCO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDCO_ECOLI pepwheel swissprot:YDCO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDCO_ECOLI pepwindow swissprot:YDCO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDCO_ECOLI sigcleave swissprot:YDCO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDCO_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=7.3 mM for glutamine {ECO 0000269|PubMed:18459799}; # BRENDA 3.5.1 2026 # BioGrid 4261985 15 # CATALYTIC ACTIVITY GLSA1_ECOLI L-glutamine + H(2)O = L-glutamate + NH(3). {ECO 0000255|HAMAP-Rule MF_00313, ECO 0000269|PubMed 18459799}. # EcoGene EG13247 glsA1 # GO_function GO:0004359 glutaminase activity; IDA:EcoCyc. # GO_process GO:0006537 glutamate biosynthetic process; IBA:GO_Central. # GO_process GO:0006543 glutamine catabolic process; IBA:GO_Central. # GO_process GO:0010447 response to acidic pH; IEP:EcoCyc. # GO_process GO:0045926 negative regulation of growth; IMP:EcoliWiki. # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.710.10 -; 1. # HAMAP MF_00313 Glutaminase # IntAct P77454 2 # InterPro IPR012338 Beta-lactam/transpept-like # InterPro IPR015868 Glutaminase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00250 Alanine, aspartate and glutamate metabolism # KEGG_Pathway ko00330 Arginine and proline metabolism # KEGG_Pathway ko00471 D-Glutamine and D-glutamate metabolism # KEGG_Pathway ko00910 Nitrogen metabolism # KEGG_Pathway ko04724 Glutamatergic synapse # KEGG_Pathway ko04727 GABAergic synapse # KEGG_Pathway ko04964 Proximal tubule bicarbonate reclamation # Organism GLSA1_ECOLI Escherichia coli (strain K12) # PANTHER PTHR12544 PTHR12544 # PATRIC 32116129 VBIEscCol129921_0506 # PDB 1U60 X-ray; 1.61 A; A/B/C/D=1-310 # PIR D64779 D64779 # Pfam PF04960 Glutaminase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Glutaminase 1 {ECO:0000255|HAMAP-Rule MF_00313} # RefSeq NP_415018 NC_000913.3 # RefSeq WP_000883034 NZ_LN832404.1 # SIMILARITY Belongs to the glutaminase family. {ECO:0000255|HAMAP- Rule MF_00313}. # SUBUNIT GLSA1_ECOLI Homotetramer. {ECO 0000255|HAMAP-Rule MF_00313, ECO 0000269|PubMed 18459799}. # SUPFAM SSF56601 SSF56601 # TIGRFAMs TIGR03814 Gln_ase # eggNOG COG2066 LUCA # eggNOG ENOG4105CSV Bacteria BLAST swissprot:GLSA1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLSA1_ECOLI BioCyc ECOL316407:JW0474-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0474-MONOMER BioCyc EcoCyc:G6261-MONOMER http://biocyc.org/getid?id=EcoCyc:G6261-MONOMER BioCyc MetaCyc:G6261-MONOMER http://biocyc.org/getid?id=MetaCyc:G6261-MONOMER COG COG2066 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2066 DIP DIP-11307N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11307N DOI 10.1021/bi800097h http://dx.doi.org/10.1021/bi800097h DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.5.1.2 {ECO:0000255|HAMAP-Rule:MF_00313} http://www.genome.jp/dbget-bin/www_bget?EC:3.5.1.2 {ECO:0000255|HAMAP-Rule:MF_00313} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 ENZYME 3.5.1.2 {ECO:0000255|HAMAP-Rule:MF_00313} http://enzyme.expasy.org/EC/3.5.1.2 {ECO:0000255|HAMAP-Rule:MF_00313} EchoBASE EB3036 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3036 EcoGene EG13247 http://www.ecogene.org/geneInfo.php?eg_id=EG13247 EnsemblBacteria AAC73587 http://www.ensemblgenomes.org/id/AAC73587 EnsemblBacteria AAC73587 http://www.ensemblgenomes.org/id/AAC73587 EnsemblBacteria BAE76264 http://www.ensemblgenomes.org/id/BAE76264 EnsemblBacteria BAE76264 http://www.ensemblgenomes.org/id/BAE76264 EnsemblBacteria BAE76264 http://www.ensemblgenomes.org/id/BAE76264 EnsemblBacteria b0485 http://www.ensemblgenomes.org/id/b0485 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004359 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004359 GO_process GO:0006537 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006537 GO_process GO:0006543 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006543 GO_process GO:0010447 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010447 GO_process GO:0045926 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045926 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.710.10 http://www.cathdb.info/version/latest/superfamily/3.40.710.10 GeneID 946187 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946187 HAMAP MF_00313 http://hamap.expasy.org/unirule/MF_00313 HOGENOM HOG000216890 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000216890&db=HOGENOM6 InParanoid P77454 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77454 IntAct P77454 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77454* IntEnz 3.5.1.2 {ECO:0000255|HAMAP-Rule:MF_00313} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.1.2 {ECO:0000255|HAMAP-Rule:MF_00313} InterPro IPR012338 http://www.ebi.ac.uk/interpro/entry/IPR012338 InterPro IPR015868 http://www.ebi.ac.uk/interpro/entry/IPR015868 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0474 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0474 KEGG_Gene eco:b0485 http://www.genome.jp/dbget-bin/www_bget?eco:b0485 KEGG_Orthology KO:K01425 http://www.genome.jp/dbget-bin/www_bget?KO:K01425 KEGG_Pathway ko00250 http://www.genome.jp/kegg-bin/show_pathway?ko00250 KEGG_Pathway ko00330 http://www.genome.jp/kegg-bin/show_pathway?ko00330 KEGG_Pathway ko00471 http://www.genome.jp/kegg-bin/show_pathway?ko00471 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Pathway ko04724 http://www.genome.jp/kegg-bin/show_pathway?ko04724 KEGG_Pathway ko04727 http://www.genome.jp/kegg-bin/show_pathway?ko04727 KEGG_Pathway ko04964 http://www.genome.jp/kegg-bin/show_pathway?ko04964 KEGG_Reaction rn:R00256 http://www.genome.jp/dbget-bin/www_bget?rn:R00256 KEGG_Reaction rn:R01579 http://www.genome.jp/dbget-bin/www_bget?rn:R01579 OMA PMNPMVN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PMNPMVN PANTHER PTHR12544 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12544 PDB 1U60 http://www.ebi.ac.uk/pdbe-srv/view/entry/1U60 PDBsum 1U60 http://www.ebi.ac.uk/pdbsum/1U60 PSORT swissprot:GLSA1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLSA1_ECOLI PSORT-B swissprot:GLSA1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLSA1_ECOLI PSORT2 swissprot:GLSA1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLSA1_ECOLI Pfam PF04960 http://pfam.xfam.org/family/PF04960 Phobius swissprot:GLSA1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLSA1_ECOLI PhylomeDB P77454 http://phylomedb.org/?seqid=P77454 ProteinModelPortal P77454 http://www.proteinmodelportal.org/query/uniprot/P77454 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18459799 http://www.ncbi.nlm.nih.gov/pubmed/18459799 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415018 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415018 RefSeq WP_000883034 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000883034 SMR P77454 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77454 STRING 511145.b0485 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0485&targetmode=cogs STRING COG2066 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2066&targetmode=cogs SUPFAM SSF56601 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56601 TIGRFAMs TIGR03814 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03814 UniProtKB GLSA1_ECOLI http://www.uniprot.org/uniprot/GLSA1_ECOLI UniProtKB-AC P77454 http://www.uniprot.org/uniprot/P77454 charge swissprot:GLSA1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLSA1_ECOLI eggNOG COG2066 http://eggnogapi.embl.de/nog_data/html/tree/COG2066 eggNOG ENOG4105CSV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CSV epestfind swissprot:GLSA1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLSA1_ECOLI garnier swissprot:GLSA1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLSA1_ECOLI helixturnhelix swissprot:GLSA1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLSA1_ECOLI hmoment swissprot:GLSA1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLSA1_ECOLI iep swissprot:GLSA1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLSA1_ECOLI inforesidue swissprot:GLSA1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLSA1_ECOLI octanol swissprot:GLSA1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLSA1_ECOLI pepcoil swissprot:GLSA1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLSA1_ECOLI pepdigest swissprot:GLSA1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLSA1_ECOLI pepinfo swissprot:GLSA1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLSA1_ECOLI pepnet swissprot:GLSA1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLSA1_ECOLI pepstats swissprot:GLSA1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLSA1_ECOLI pepwheel swissprot:GLSA1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLSA1_ECOLI pepwindow swissprot:GLSA1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLSA1_ECOLI sigcleave swissprot:GLSA1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLSA1_ECOLI ## Database ID URL or Descriptions # BioGrid 4261399 7 # CATALYTIC ACTIVITY PRP1_ECOLI [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate. # COFACTOR PRP1_ECOLI Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000250}; Note=Binds 2 manganese ions per subunit. {ECO 0000250}; # EcoGene EG14026 pphA # FUNCTION PRP1_ECOLI Plays a key role in signaling protein misfolding via the CpxR/CPXA transducing system. It also modulates the phosphorylated status of many phosphoproteins in E.coli, some of which acting as major chaperones. Has been shown, in vitro, to act on Ser, Thr and Tyr-phosphorylated substrates. # GO_function GO:0008138 protein tyrosine/serine/threonine phosphatase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0009266 response to temperature stimulus; IEP:EcoCyc. # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # Gene3D 3.60.21.10 -; 1. # InterPro IPR004843 Calcineurin-like_PHP_ApaH # InterPro IPR006186 Ser/Thr-sp_prot-phosphatase # InterPro IPR029052 Metallo-depent_PP-like # KEGG_Brite ko01000 Enzymes # Organism PRP1_ECOLI Escherichia coli (strain K12) # PATRIC 32118997 VBIEscCol129921_1916 # PIR F64945 F64945 # PROSITE PS00125 SER_THR_PHOSPHATASE # Pfam PF00149 Metallophos # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PRP1_ECOLI Serine/threonine-protein phosphatase 1 # RefSeq NP_416352 NC_000913.3 # RefSeq WP_000812724 NZ_LN832404.1 # SIMILARITY Belongs to the PPP phosphatase family. PP-1 subfamily. {ECO 0000305}. # SUPFAM SSF56300 SSF56300 # eggNOG COG0639 LUCA # eggNOG ENOG4108R1E Bacteria BLAST swissprot:PRP1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PRP1_ECOLI BioCyc ECOL316407:JW1827-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1827-MONOMER BioCyc EcoCyc:G7011-MONOMER http://biocyc.org/getid?id=EcoCyc:G7011-MONOMER BioCyc MetaCyc:G7011-MONOMER http://biocyc.org/getid?id=MetaCyc:G7011-MONOMER COG COG0639 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0639 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/emboj/16.7.1670 http://dx.doi.org/10.1093/emboj/16.7.1670 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.3.16 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.16 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U51991 http://www.ebi.ac.uk/ena/data/view/U51991 ENZYME 3.1.3.16 http://enzyme.expasy.org/EC/3.1.3.16 EchoBASE EB3780 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3780 EcoGene EG14026 http://www.ecogene.org/geneInfo.php?eg_id=EG14026 EnsemblBacteria AAC74908 http://www.ensemblgenomes.org/id/AAC74908 EnsemblBacteria AAC74908 http://www.ensemblgenomes.org/id/AAC74908 EnsemblBacteria BAA15649 http://www.ensemblgenomes.org/id/BAA15649 EnsemblBacteria BAA15649 http://www.ensemblgenomes.org/id/BAA15649 EnsemblBacteria BAA15649 http://www.ensemblgenomes.org/id/BAA15649 EnsemblBacteria b1838 http://www.ensemblgenomes.org/id/b1838 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008138 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008138 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0009266 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009266 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.60.21.10 http://www.cathdb.info/version/latest/superfamily/3.60.21.10 GeneID 946356 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946356 HOGENOM HOG000251869 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000251869&db=HOGENOM6 InParanoid P55798 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P55798 IntAct P55798 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P55798* IntEnz 3.1.3.16 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.16 InterPro IPR004843 http://www.ebi.ac.uk/interpro/entry/IPR004843 InterPro IPR006186 http://www.ebi.ac.uk/interpro/entry/IPR006186 InterPro IPR029052 http://www.ebi.ac.uk/interpro/entry/IPR029052 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1827 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1827 KEGG_Gene eco:b1838 http://www.genome.jp/dbget-bin/www_bget?eco:b1838 KEGG_Orthology KO:K07313 http://www.genome.jp/dbget-bin/www_bget?KO:K07313 OMA MNGGDWY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MNGGDWY PROSITE PS00125 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00125 PSORT swissprot:PRP1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PRP1_ECOLI PSORT-B swissprot:PRP1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PRP1_ECOLI PSORT2 swissprot:PRP1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PRP1_ECOLI Pfam PF00149 http://pfam.xfam.org/family/PF00149 Phobius swissprot:PRP1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PRP1_ECOLI PhylomeDB P55798 http://phylomedb.org/?seqid=P55798 ProteinModelPortal P55798 http://www.proteinmodelportal.org/query/uniprot/P55798 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9130712 http://www.ncbi.nlm.nih.gov/pubmed/9130712 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416352 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416352 RefSeq WP_000812724 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000812724 SMR P55798 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P55798 STRING 511145.b1838 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1838&targetmode=cogs STRING COG0639 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0639&targetmode=cogs SUPFAM SSF56300 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56300 UniProtKB PRP1_ECOLI http://www.uniprot.org/uniprot/PRP1_ECOLI UniProtKB-AC P55798 http://www.uniprot.org/uniprot/P55798 charge swissprot:PRP1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PRP1_ECOLI eggNOG COG0639 http://eggnogapi.embl.de/nog_data/html/tree/COG0639 eggNOG ENOG4108R1E http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108R1E epestfind swissprot:PRP1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PRP1_ECOLI garnier swissprot:PRP1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PRP1_ECOLI helixturnhelix swissprot:PRP1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PRP1_ECOLI hmoment swissprot:PRP1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PRP1_ECOLI iep swissprot:PRP1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PRP1_ECOLI inforesidue swissprot:PRP1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PRP1_ECOLI octanol swissprot:PRP1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PRP1_ECOLI pepcoil swissprot:PRP1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PRP1_ECOLI pepdigest swissprot:PRP1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PRP1_ECOLI pepinfo swissprot:PRP1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PRP1_ECOLI pepnet swissprot:PRP1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PRP1_ECOLI pepstats swissprot:PRP1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PRP1_ECOLI pepwheel swissprot:PRP1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PRP1_ECOLI pepwindow swissprot:PRP1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PRP1_ECOLI sigcleave swissprot:PRP1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PRP1_ECOLI ## Database ID URL or Descriptions # BioGrid 4261937 5 # EcoGene EG10011 yaaA # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_process GO:0033194 response to hydroperoxide; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_process GO:0006950 response to stress # HAMAP MF_00652 UPF0246 # IntAct P0A8I3 5 # InterPro IPR005583 YaaA # Organism YAAA_ECOLI Escherichia coli (strain K12) # PATRIC 32115107 VBIEscCol129921_0005 # PDB 5CAJ X-ray; 1.65 A; A/B=2-258 # PIR S40534 Q3ECTC # Pfam PF03883 H2O2_YaaD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAAA_ECOLI UPF0246 protein YaaA # RefSeq NP_414547 NC_000913.3 # RefSeq WP_000906197 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0246 family. {ECO 0000305}. # eggNOG COG3022 LUCA # eggNOG ENOG4105D1Q Bacteria BLAST swissprot:YAAA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAAA_ECOLI BioCyc ECOL316407:JW0005-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0005-MONOMER BioCyc EcoCyc:EG10011-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10011-MONOMER COG COG3022 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3022 DIP DIP-35783N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35783N DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/11.21.7331 http://dx.doi.org/10.1093/nar/11.21.7331 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB0011 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0011 EcoGene EG10011 http://www.ecogene.org/geneInfo.php?eg_id=EG10011 EnsemblBacteria AAC73117 http://www.ensemblgenomes.org/id/AAC73117 EnsemblBacteria AAC73117 http://www.ensemblgenomes.org/id/AAC73117 EnsemblBacteria BAB96584 http://www.ensemblgenomes.org/id/BAB96584 EnsemblBacteria BAB96584 http://www.ensemblgenomes.org/id/BAB96584 EnsemblBacteria BAB96584 http://www.ensemblgenomes.org/id/BAB96584 EnsemblBacteria b0006 http://www.ensemblgenomes.org/id/b0006 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_process GO:0033194 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033194 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 944749 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944749 HAMAP MF_00652 http://hamap.expasy.org/unirule/MF_00652 HOGENOM HOG000218488 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218488&db=HOGENOM6 InParanoid P0A8I3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8I3 IntAct P0A8I3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8I3* InterPro IPR005583 http://www.ebi.ac.uk/interpro/entry/IPR005583 KEGG_Gene ecj:JW0005 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0005 KEGG_Gene eco:b0006 http://www.genome.jp/dbget-bin/www_bget?eco:b0006 KEGG_Orthology KO:K09861 http://www.genome.jp/dbget-bin/www_bget?KO:K09861 MINT MINT-1310738 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1310738 OMA KARGMMS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KARGMMS PDB 5CAJ http://www.ebi.ac.uk/pdbe-srv/view/entry/5CAJ PDBsum 5CAJ http://www.ebi.ac.uk/pdbsum/5CAJ PSORT swissprot:YAAA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAAA_ECOLI PSORT-B swissprot:YAAA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAAA_ECOLI PSORT2 swissprot:YAAA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAAA_ECOLI Pfam PF03883 http://pfam.xfam.org/family/PF03883 Phobius swissprot:YAAA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAAA_ECOLI PhylomeDB P0A8I3 http://phylomedb.org/?seqid=P0A8I3 ProteinModelPortal P0A8I3 http://www.proteinmodelportal.org/query/uniprot/P0A8I3 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6316258 http://www.ncbi.nlm.nih.gov/pubmed/6316258 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414547 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414547 RefSeq WP_000906197 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000906197 SMR P0A8I3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8I3 STRING 511145.b0006 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0006&targetmode=cogs STRING COG3022 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3022&targetmode=cogs UniProtKB YAAA_ECOLI http://www.uniprot.org/uniprot/YAAA_ECOLI UniProtKB-AC P0A8I3 http://www.uniprot.org/uniprot/P0A8I3 charge swissprot:YAAA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAAA_ECOLI eggNOG COG3022 http://eggnogapi.embl.de/nog_data/html/tree/COG3022 eggNOG ENOG4105D1Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D1Q epestfind swissprot:YAAA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAAA_ECOLI garnier swissprot:YAAA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAAA_ECOLI helixturnhelix swissprot:YAAA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAAA_ECOLI hmoment swissprot:YAAA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAAA_ECOLI iep swissprot:YAAA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAAA_ECOLI inforesidue swissprot:YAAA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAAA_ECOLI octanol swissprot:YAAA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAAA_ECOLI pepcoil swissprot:YAAA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAAA_ECOLI pepdigest swissprot:YAAA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAAA_ECOLI pepinfo swissprot:YAAA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAAA_ECOLI pepnet swissprot:YAAA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAAA_ECOLI pepstats swissprot:YAAA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAAA_ECOLI pepwheel swissprot:YAAA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAAA_ECOLI pepwindow swissprot:YAAA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAAA_ECOLI sigcleave swissprot:YAAA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAAA_ECOLI ## Database ID URL or Descriptions # AltName MURJ_ECOLI Peptidoglycan biosynthesis protein MurJ # BioGrid 4260079 316 # CDD cd13123 MATE_MurJ_like # EcoGene EG13880 murJ # FUNCTION MURJ_ECOLI Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. {ECO 0000269|PubMed 18708495, ECO 0000269|PubMed 18832143, ECO 0000269|PubMed 25013077}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_function GO:0015648 lipid-linked peptidoglycan transporter activity; IDA:EcoCyc. # GO_process GO:0008360 regulation of cell shape; IEA:UniProtKB-KW. # GO_process GO:0009252 peptidoglycan biosynthetic process; IMP:EcoCyc. # GO_process GO:0015836 lipid-linked peptidoglycan transport; IDA:EcoCyc. # GO_process GO:0034203 glycolipid translocation; IMP:CACAO. # GO_process GO:0034204 lipid translocation; IDA:EcoCyc. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0061024 membrane organization # GOslim_process GO:0071554 cell wall organization or biogenesis # InterPro IPR004268 MurJ # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko00550 Peptidoglycan biosynthesis # MISCELLANEOUS MURJ_ECOLI FtsW (AC P0ABG4) is also proposed to act as a lipid II flippase. The identity of the lipid II flippase is controversial with conflicting in vivo and in vitro results. # Organism MURJ_ECOLI Escherichia coli (strain K12) # PATRIC 32117377 VBIEscCol129921_1111 # PIR B64850 B64850 # PIRSF PIRSF002869 MviN # PRINTS PR01806 VIRFACTRMVIN # Pfam PF03023 MVIN # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MURJ_ECOLI Lipid II flippase MurJ # RefSeq NP_415587 NC_000913.3 # RefSeq WP_001050683 NZ_LN832404.1 # SIMILARITY Belongs to the MurJ/MviN family. {ECO 0000305}. # SUBCELLULAR LOCATION MURJ_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 23935042}; Multi- pass membrane protein {ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 23935042}. # TCDB 2.A.66.4 the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily # TIGRFAMs TIGR01695 murJ_mviN # eggNOG COG0728 LUCA # eggNOG ENOG4105CJR Bacteria BLAST swissprot:MURJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MURJ_ECOLI BioCyc ECOL316407:JW1056-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1056-MONOMER BioCyc EcoCyc:G6561-MONOMER http://biocyc.org/getid?id=EcoCyc:G6561-MONOMER BioCyc MetaCyc:G6561-MONOMER http://biocyc.org/getid?id=MetaCyc:G6561-MONOMER COG COG0728 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0728 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0808352105 http://dx.doi.org/10.1073/pnas.0808352105 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.1254522 http://dx.doi.org/10.1126/science.1254522 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00551-08 http://dx.doi.org/10.1128/JB.00551-08 DOI 10.1128/JB.00731-13 http://dx.doi.org/10.1128/JB.00731-13 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3639 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3639 EcoGene EG13880 http://www.ecogene.org/geneInfo.php?eg_id=EG13880 EnsemblBacteria AAC74153 http://www.ensemblgenomes.org/id/AAC74153 EnsemblBacteria AAC74153 http://www.ensemblgenomes.org/id/AAC74153 EnsemblBacteria BAA35877 http://www.ensemblgenomes.org/id/BAA35877 EnsemblBacteria BAA35877 http://www.ensemblgenomes.org/id/BAA35877 EnsemblBacteria BAA35877 http://www.ensemblgenomes.org/id/BAA35877 EnsemblBacteria b1069 http://www.ensemblgenomes.org/id/b1069 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015648 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015648 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0009252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009252 GO_process GO:0015836 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015836 GO_process GO:0034203 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034203 GO_process GO:0034204 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034204 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0061024 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 GeneID 945487 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945487 HOGENOM HOG000263812 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000263812&db=HOGENOM6 InParanoid P0AF16 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AF16 IntAct P0AF16 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AF16* InterPro IPR004268 http://www.ebi.ac.uk/interpro/entry/IPR004268 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW1056 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1056 KEGG_Gene eco:b1069 http://www.genome.jp/dbget-bin/www_bget?eco:b1069 KEGG_Orthology KO:K03980 http://www.genome.jp/dbget-bin/www_bget?KO:K03980 KEGG_Pathway ko00550 http://www.genome.jp/kegg-bin/show_pathway?ko00550 OMA IFAEGSF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IFAEGSF PRINTS PR01806 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01806 PSORT swissprot:MURJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MURJ_ECOLI PSORT-B swissprot:MURJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MURJ_ECOLI PSORT2 swissprot:MURJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MURJ_ECOLI Pfam PF03023 http://pfam.xfam.org/family/PF03023 Phobius swissprot:MURJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MURJ_ECOLI PhylomeDB P0AF16 http://phylomedb.org/?seqid=P0AF16 ProteinModelPortal P0AF16 http://www.proteinmodelportal.org/query/uniprot/P0AF16 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18708495 http://www.ncbi.nlm.nih.gov/pubmed/18708495 PubMed 18832143 http://www.ncbi.nlm.nih.gov/pubmed/18832143 PubMed 23935042 http://www.ncbi.nlm.nih.gov/pubmed/23935042 PubMed 25013077 http://www.ncbi.nlm.nih.gov/pubmed/25013077 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415587 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415587 RefSeq WP_001050683 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001050683 STRING 511145.b1069 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1069&targetmode=cogs STRING COG0728 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0728&targetmode=cogs TCDB 2.A.66.4 http://www.tcdb.org/search/result.php?tc=2.A.66.4 TIGRFAMs TIGR01695 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01695 UniProtKB MURJ_ECOLI http://www.uniprot.org/uniprot/MURJ_ECOLI UniProtKB-AC P0AF16 http://www.uniprot.org/uniprot/P0AF16 charge swissprot:MURJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MURJ_ECOLI eggNOG COG0728 http://eggnogapi.embl.de/nog_data/html/tree/COG0728 eggNOG ENOG4105CJR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CJR epestfind swissprot:MURJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MURJ_ECOLI garnier swissprot:MURJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MURJ_ECOLI helixturnhelix swissprot:MURJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MURJ_ECOLI hmoment swissprot:MURJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MURJ_ECOLI iep swissprot:MURJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MURJ_ECOLI inforesidue swissprot:MURJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MURJ_ECOLI octanol swissprot:MURJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MURJ_ECOLI pepcoil swissprot:MURJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MURJ_ECOLI pepdigest swissprot:MURJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MURJ_ECOLI pepinfo swissprot:MURJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MURJ_ECOLI pepnet swissprot:MURJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MURJ_ECOLI pepstats swissprot:MURJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MURJ_ECOLI pepwheel swissprot:MURJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MURJ_ECOLI pepwindow swissprot:MURJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MURJ_ECOLI sigcleave swissprot:MURJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MURJ_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES QOR2_ECOLI Kinetic parameters KM=65.6 uM for methyl-1,4-benzoquinone (MBQ) {ECO 0000269|PubMed 18455185}; KM=18 uM for NADPH {ECO 0000269|PubMed 18455185}; # BRENDA 1.6.5 2026 # BioGrid 4263443 13 # CATALYTIC ACTIVITY NAD(P)H + a quinone = NAD(P)(+) + a hydroquinone. {ECO:0000269|PubMed 18455185}. # EcoGene EG12507 qorB # FUNCTION QOR2_ECOLI Quinone oxidoreductase that may play some additional role beyond quinone reduction. Potential redox sensor protein. Overexpression induces retardation of growth. {ECO 0000269|PubMed 18455185}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003955 NAD(P)H dehydrogenase (quinone) activity; IEA:UniProtKB-EC. # GO_function GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # Gene3D 3.40.50.720 -; 1. # IntAct P39315 3 # InterPro IPR008030 NmrA-like # InterPro IPR016040 NAD(P)-bd_dom # Organism QOR2_ECOLI Escherichia coli (strain K12) # PATRIC 32123997 VBIEscCol129921_4343 # PDB 2ZCU X-ray; 1.80 A; A=1-286 # PDB 2ZCV X-ray; 2.30 A; A=1-286 # PIR S56436 S56436 # Pfam PF05368 NmrA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName QOR2_ECOLI Quinone oxidoreductase 2 # RefSeq NP_418632 NC_000913.3 # RefSeq WP_000560561 NZ_LN832404.1 # SIMILARITY Belongs to the NmrA-type oxidoreductase family. {ECO 0000305}. # SUBUNIT Monomer. {ECO:0000269|PubMed 18455185}. # SUPFAM SSF51735 SSF51735 # eggNOG COG0702 LUCA # eggNOG ENOG4105ECR Bacteria BLAST swissprot:QOR2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:QOR2_ECOLI BioCyc ECOL316407:JW4169-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4169-MONOMER BioCyc EcoCyc:G7868-MONOMER http://biocyc.org/getid?id=EcoCyc:G7868-MONOMER BioCyc MetaCyc:G7868-MONOMER http://biocyc.org/getid?id=MetaCyc:G7868-MONOMER DIP DIP-12935N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12935N DOI 10.1016/j.jmb.2008.04.003 http://dx.doi.org/10.1016/j.jmb.2008.04.003 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.6.5.2 http://www.genome.jp/dbget-bin/www_bget?EC:1.6.5.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 1.6.5.2 http://enzyme.expasy.org/EC/1.6.5.2 EchoBASE EB2400 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2400 EcoGene EG12507 http://www.ecogene.org/geneInfo.php?eg_id=EG12507 EnsemblBacteria AAC77168 http://www.ensemblgenomes.org/id/AAC77168 EnsemblBacteria AAC77168 http://www.ensemblgenomes.org/id/AAC77168 EnsemblBacteria BAE78212 http://www.ensemblgenomes.org/id/BAE78212 EnsemblBacteria BAE78212 http://www.ensemblgenomes.org/id/BAE78212 EnsemblBacteria BAE78212 http://www.ensemblgenomes.org/id/BAE78212 EnsemblBacteria b4211 http://www.ensemblgenomes.org/id/b4211 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003955 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003955 GO_function GO:0016655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016655 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 948731 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948731 HOGENOM HOG000035268 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000035268&db=HOGENOM6 InParanoid P39315 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39315 IntAct P39315 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39315* IntEnz 1.6.5.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.6.5.2 InterPro IPR008030 http://www.ebi.ac.uk/interpro/entry/IPR008030 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 KEGG_Gene ecj:JW4169 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4169 KEGG_Gene eco:b4211 http://www.genome.jp/dbget-bin/www_bget?eco:b4211 MINT MINT-1227197 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1227197 OMA CADEGRI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CADEGRI PDB 2ZCU http://www.ebi.ac.uk/pdbe-srv/view/entry/2ZCU PDB 2ZCV http://www.ebi.ac.uk/pdbe-srv/view/entry/2ZCV PDBsum 2ZCU http://www.ebi.ac.uk/pdbsum/2ZCU PDBsum 2ZCV http://www.ebi.ac.uk/pdbsum/2ZCV PSORT swissprot:QOR2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:QOR2_ECOLI PSORT-B swissprot:QOR2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:QOR2_ECOLI PSORT2 swissprot:QOR2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:QOR2_ECOLI Pfam PF05368 http://pfam.xfam.org/family/PF05368 Phobius swissprot:QOR2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:QOR2_ECOLI PhylomeDB P39315 http://phylomedb.org/?seqid=P39315 ProteinModelPortal P39315 http://www.proteinmodelportal.org/query/uniprot/P39315 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18455185 http://www.ncbi.nlm.nih.gov/pubmed/18455185 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418632 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418632 RefSeq WP_000560561 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000560561 SMR P39315 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39315 STRING 511145.b4211 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4211&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB QOR2_ECOLI http://www.uniprot.org/uniprot/QOR2_ECOLI UniProtKB-AC P39315 http://www.uniprot.org/uniprot/P39315 charge swissprot:QOR2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:QOR2_ECOLI eggNOG COG0702 http://eggnogapi.embl.de/nog_data/html/tree/COG0702 eggNOG ENOG4105ECR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ECR epestfind swissprot:QOR2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:QOR2_ECOLI garnier swissprot:QOR2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:QOR2_ECOLI helixturnhelix swissprot:QOR2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:QOR2_ECOLI hmoment swissprot:QOR2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:QOR2_ECOLI iep swissprot:QOR2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:QOR2_ECOLI inforesidue swissprot:QOR2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:QOR2_ECOLI octanol swissprot:QOR2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:QOR2_ECOLI pepcoil swissprot:QOR2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:QOR2_ECOLI pepdigest swissprot:QOR2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:QOR2_ECOLI pepinfo swissprot:QOR2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:QOR2_ECOLI pepnet swissprot:QOR2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:QOR2_ECOLI pepstats swissprot:QOR2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:QOR2_ECOLI pepwheel swissprot:QOR2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:QOR2_ECOLI pepwindow swissprot:QOR2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:QOR2_ECOLI sigcleave swissprot:QOR2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:QOR2_ECOLI ## Database ID URL or Descriptions # BRENDA 3.6.4.12 2026 # BioGrid 4259619 148 # CATALYTIC ACTIVITY RECQ_ECOLI ATP + H(2)O = ADP + phosphate. # EcoGene EG10833 recQ # FUNCTION RECQ_ECOLI Involved in the RecF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase. {ECO 0000269|PubMed 2164680}. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0017117 single-stranded DNA-dependent ATP-dependent DNA helicase complex; IDA:EcoliWiki. # GO_component GO:0030894 replisome; IDA:UniProtKB. # GO_component GO:0043590 bacterial nucleoid; IDA:UniProtKB. # GO_function GO:0003677 DNA binding; IDA:EcoliWiki. # GO_function GO:0004003 ATP-dependent DNA helicase activity; IDA:EcoliWiki. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0008094 DNA-dependent ATPase activity; IDA:EcoliWiki. # GO_function GO:0008270 zinc ion binding; IMP:EcoliWiki. # GO_function GO:0009378 four-way junction helicase activity; IBA:GO_Central. # GO_function GO:0016887 ATPase activity; IDA:EcoliWiki. # GO_function GO:0017116 single-stranded DNA-dependent ATP-dependent DNA helicase activity; IDA:EcoliWiki. # GO_function GO:0043140 ATP-dependent 3'-5' DNA helicase activity; IBA:GO_Central. # GO_function GO:0046914 transition metal ion binding; IDA:EcoliWiki. # GO_process GO:0006260 DNA replication; IEA:InterPro. # GO_process GO:0006281 DNA repair; IGI:EcoliWiki. # GO_process GO:0006310 DNA recombination; IDA:EcoliWiki. # GO_process GO:0006974 cellular response to DNA damage stimulus; IGI:EcoliWiki. # GO_process GO:0009432 SOS response; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0043226 organelle # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004386 helicase activity # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # Gene3D 1.10.10.10 -; 1. # Gene3D 1.10.150.80 -; 1. # Gene3D 3.40.50.300 -; 2. # IntAct P15043 11 # InterPro IPR001650 Helicase_C # InterPro IPR002121 HRDC_dom # InterPro IPR004589 DNA_helicase_ATP-dep_RecQ # InterPro IPR006293 DNA_helicase_ATP-dep_RecQ_bac # InterPro IPR010997 HRDC-like # InterPro IPR011545 DEAD/DEAH_box_helicase_dom # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR014001 Helicase_ATP-bd # InterPro IPR018982 RQC_domain # InterPro IPR027417 P-loop_NTPase # InterPro IPR032284 RecQ_Zn-bd # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko03018 RNA degradation # Organism RECQ_ECOLI Escherichia coli (strain K12) # PATRIC 32123145 VBIEscCol129921_3938 # PDB 1OYW X-ray; 1.80 A; A=1-522 # PDB 1OYY X-ray; 2.50 A; A=1-523 # PDB 1WUD X-ray; 2.20 A; A/B/D=524-609 # PROSITE PS50967 HRDC # PROSITE PS51192 HELICASE_ATP_BIND_1 # PROSITE PS51194 HELICASE_CTER # Pfam PF00270 DEAD # Pfam PF00271 Helicase_C # Pfam PF00570 HRDC # Pfam PF09382 RQC # Pfam PF16124 RecQ_Zn_bind # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RECQ_ECOLI ATP-dependent DNA helicase RecQ # RefSeq WP_000035581 NZ_LN832404.1 # RefSeq YP_026263 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA24517.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAA67618.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the helicase family. RecQ subfamily. {ECO 0000305}. # SIMILARITY Contains 1 HRDC domain. {ECO:0000255|PROSITE- ProRule PRU00328}. # SIMILARITY Contains 1 helicase ATP-binding domain. {ECO:0000255|PROSITE-ProRule PRU00541}. # SIMILARITY Contains 1 helicase C-terminal domain. {ECO:0000255|PROSITE-ProRule PRU00542}. # SMART SM00341 HRDC # SMART SM00487 DEXDc # SMART SM00490 HELICc # SMART SM00956 RQC # SUPFAM SSF47819 SSF47819 # SUPFAM SSF52540 SSF52540; 2 # TIGRFAMs TIGR00614 recQ_fam # TIGRFAMs TIGR01389 recQ # eggNOG COG0514 LUCA # eggNOG ENOG4105C9U Bacteria BLAST swissprot:RECQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RECQ_ECOLI BioCyc ECOL316407:JW5855-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5855-MONOMER BioCyc EcoCyc:EG10833-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10833-MONOMER BioCyc MetaCyc:EG10833-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10833-MONOMER COG COG0514 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0514 DIP DIP-10656N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10656N DOI 10.1007/BF00430442 http://dx.doi.org/10.1007/BF00430442 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.87.14.5363 http://dx.doi.org/10.1073/pnas.87.14.5363 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.4.12 http://www.genome.jp/dbget-bin/www_bget?EC:3.6.4.12 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M30198 http://www.ebi.ac.uk/ena/data/view/M30198 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.6.4.12 http://enzyme.expasy.org/EC/3.6.4.12 EchoBASE EB0826 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0826 EcoGene EG10833 http://www.ecogene.org/geneInfo.php?eg_id=EG10833 EnsemblBacteria AAT48221 http://www.ensemblgenomes.org/id/AAT48221 EnsemblBacteria AAT48221 http://www.ensemblgenomes.org/id/AAT48221 EnsemblBacteria BAE77479 http://www.ensemblgenomes.org/id/BAE77479 EnsemblBacteria BAE77479 http://www.ensemblgenomes.org/id/BAE77479 EnsemblBacteria BAE77479 http://www.ensemblgenomes.org/id/BAE77479 EnsemblBacteria b3822 http://www.ensemblgenomes.org/id/b3822 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0017117 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017117 GO_component GO:0030894 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030894 GO_component GO:0043590 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043590 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004003 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004003 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008094 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008094 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0009378 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009378 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_function GO:0017116 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017116 GO_function GO:0043140 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043140 GO_function GO:0046914 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046914 GO_process GO:0006260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260 GO_process GO:0006281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006281 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0009432 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009432 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0043226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004386 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 1.10.150.80 http://www.cathdb.info/version/latest/superfamily/1.10.150.80 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948318 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948318 HOGENOM HOG000044388 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000044388&db=HOGENOM6 InParanoid P15043 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P15043 IntAct P15043 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P15043* IntEnz 3.6.4.12 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.4.12 InterPro IPR001650 http://www.ebi.ac.uk/interpro/entry/IPR001650 InterPro IPR002121 http://www.ebi.ac.uk/interpro/entry/IPR002121 InterPro IPR004589 http://www.ebi.ac.uk/interpro/entry/IPR004589 InterPro IPR006293 http://www.ebi.ac.uk/interpro/entry/IPR006293 InterPro IPR010997 http://www.ebi.ac.uk/interpro/entry/IPR010997 InterPro IPR011545 http://www.ebi.ac.uk/interpro/entry/IPR011545 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR014001 http://www.ebi.ac.uk/interpro/entry/IPR014001 InterPro IPR018982 http://www.ebi.ac.uk/interpro/entry/IPR018982 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR032284 http://www.ebi.ac.uk/interpro/entry/IPR032284 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW5855 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5855 KEGG_Gene eco:b3822 http://www.genome.jp/dbget-bin/www_bget?eco:b3822 KEGG_Orthology KO:K03654 http://www.genome.jp/dbget-bin/www_bget?KO:K03654 KEGG_Pathway ko03018 http://www.genome.jp/kegg-bin/show_pathway?ko03018 MINT MINT-1223947 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1223947 OMA WDATEPA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WDATEPA PDB 1OYW http://www.ebi.ac.uk/pdbe-srv/view/entry/1OYW PDB 1OYY http://www.ebi.ac.uk/pdbe-srv/view/entry/1OYY PDB 1WUD http://www.ebi.ac.uk/pdbe-srv/view/entry/1WUD PDBsum 1OYW http://www.ebi.ac.uk/pdbsum/1OYW PDBsum 1OYY http://www.ebi.ac.uk/pdbsum/1OYY PDBsum 1WUD http://www.ebi.ac.uk/pdbsum/1WUD PROSITE PS50967 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50967 PROSITE PS51192 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51192 PROSITE PS51194 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51194 PSORT swissprot:RECQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RECQ_ECOLI PSORT-B swissprot:RECQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RECQ_ECOLI PSORT2 swissprot:RECQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RECQ_ECOLI Pfam PF00270 http://pfam.xfam.org/family/PF00270 Pfam PF00271 http://pfam.xfam.org/family/PF00271 Pfam PF00570 http://pfam.xfam.org/family/PF00570 Pfam PF09382 http://pfam.xfam.org/family/PF09382 Pfam PF16124 http://pfam.xfam.org/family/PF16124 Phobius swissprot:RECQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RECQ_ECOLI PhylomeDB P15043 http://phylomedb.org/?seqid=P15043 ProteinModelPortal P15043 http://www.proteinmodelportal.org/query/uniprot/P15043 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2164680 http://www.ncbi.nlm.nih.gov/pubmed/2164680 PubMed 3027506 http://www.ncbi.nlm.nih.gov/pubmed/3027506 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000035581 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000035581 RefSeq YP_026263 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026263 SMART SM00341 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00341 SMART SM00487 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00487 SMART SM00490 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00490 SMART SM00956 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00956 SMR P15043 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P15043 STRING 511145.b3822 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3822&targetmode=cogs STRING COG0514 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0514&targetmode=cogs SUPFAM SSF47819 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47819 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR00614 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00614 TIGRFAMs TIGR01389 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01389 UniProtKB RECQ_ECOLI http://www.uniprot.org/uniprot/RECQ_ECOLI UniProtKB-AC P15043 http://www.uniprot.org/uniprot/P15043 charge swissprot:RECQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RECQ_ECOLI eggNOG COG0514 http://eggnogapi.embl.de/nog_data/html/tree/COG0514 eggNOG ENOG4105C9U http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C9U epestfind swissprot:RECQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RECQ_ECOLI garnier swissprot:RECQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RECQ_ECOLI helixturnhelix swissprot:RECQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RECQ_ECOLI hmoment swissprot:RECQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RECQ_ECOLI iep swissprot:RECQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RECQ_ECOLI inforesidue swissprot:RECQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RECQ_ECOLI octanol swissprot:RECQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RECQ_ECOLI pepcoil swissprot:RECQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RECQ_ECOLI pepdigest swissprot:RECQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RECQ_ECOLI pepinfo swissprot:RECQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RECQ_ECOLI pepnet swissprot:RECQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RECQ_ECOLI pepstats swissprot:RECQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RECQ_ECOLI pepwheel swissprot:RECQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RECQ_ECOLI pepwindow swissprot:RECQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RECQ_ECOLI sigcleave swissprot:RECQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RECQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4259196 5 # EcoGene EG11282 hyfB # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0008137 NADH dehydrogenase (ubiquinone) activity; IEA:InterPro. # GO_process GO:0042773 ATP synthesis coupled electron transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006091 generation of precursor metabolites and energy # IntAct P23482 3 # InterPro IPR001750 ND/Mrp_mem # InterPro IPR003918 NADH_UbQ_OxRdtase # KEGG_Brite ko01000 Enzymes # Organism HYFB_ECOLI Escherichia coli (strain K12) # PATRIC 32120351 VBIEscCol129921_2578 # PIR A65024 A65024 # PRINTS PR01437 NUOXDRDTASE4 # Pfam PF00361 Proton_antipo_M # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HYFB_ECOLI Hydrogenase-4 component B # RefSeq NP_416977 NC_000913.3 # RefSeq WP_000339455 NZ_LN832404.1 # SIMILARITY Belongs to the complex I subunit 5 family. {ECO 0000305}. # SUBCELLULAR LOCATION HYFB_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 3.D.1.9 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family # eggNOG COG0651 LUCA # eggNOG ENOG4108JPZ Bacteria BLAST swissprot:HYFB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HYFB_ECOLI BioCyc ECOL316407:JW2467-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2467-MONOMER BioCyc EcoCyc:MONOMER0-153 http://biocyc.org/getid?id=EcoCyc:MONOMER0-153 COG COG0651 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0651 DIP DIP-9984N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9984N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1099/00221287-137-2-361 http://dx.doi.org/10.1099/00221287-137-2-361 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M63654 http://www.ebi.ac.uk/ena/data/view/M63654 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- EchoBASE EB1259 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1259 EcoGene EG11282 http://www.ecogene.org/geneInfo.php?eg_id=EG11282 EnsemblBacteria AAC75535 http://www.ensemblgenomes.org/id/AAC75535 EnsemblBacteria AAC75535 http://www.ensemblgenomes.org/id/AAC75535 EnsemblBacteria BAA16360 http://www.ensemblgenomes.org/id/BAA16360 EnsemblBacteria BAA16360 http://www.ensemblgenomes.org/id/BAA16360 EnsemblBacteria BAA16360 http://www.ensemblgenomes.org/id/BAA16360 EnsemblBacteria b2482 http://www.ensemblgenomes.org/id/b2482 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008137 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008137 GO_process GO:0042773 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042773 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GeneID 946961 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946961 HOGENOM HOG000278686 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278686&db=HOGENOM6 InParanoid P23482 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23482 IntAct P23482 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P23482* IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR001750 http://www.ebi.ac.uk/interpro/entry/IPR001750 InterPro IPR003918 http://www.ebi.ac.uk/interpro/entry/IPR003918 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2467 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2467 KEGG_Gene eco:b2482 http://www.genome.jp/dbget-bin/www_bget?eco:b2482 KEGG_Orthology KO:K12137 http://www.genome.jp/dbget-bin/www_bget?KO:K12137 MINT MINT-1254904 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1254904 OMA AAMCFVK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AAMCFVK PRINTS PR01437 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01437 PSORT swissprot:HYFB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HYFB_ECOLI PSORT-B swissprot:HYFB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HYFB_ECOLI PSORT2 swissprot:HYFB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HYFB_ECOLI Pfam PF00361 http://pfam.xfam.org/family/PF00361 Phobius swissprot:HYFB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HYFB_ECOLI PhylomeDB P23482 http://phylomedb.org/?seqid=P23482 ProteinModelPortal P23482 http://www.proteinmodelportal.org/query/uniprot/P23482 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2016588 http://www.ncbi.nlm.nih.gov/pubmed/2016588 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416977 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416977 RefSeq WP_000339455 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000339455 STRING 511145.b2482 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2482&targetmode=cogs STRING COG0651 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0651&targetmode=cogs TCDB 3.D.1.9 http://www.tcdb.org/search/result.php?tc=3.D.1.9 UniProtKB HYFB_ECOLI http://www.uniprot.org/uniprot/HYFB_ECOLI UniProtKB-AC P23482 http://www.uniprot.org/uniprot/P23482 charge swissprot:HYFB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HYFB_ECOLI eggNOG COG0651 http://eggnogapi.embl.de/nog_data/html/tree/COG0651 eggNOG ENOG4108JPZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108JPZ epestfind swissprot:HYFB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HYFB_ECOLI garnier swissprot:HYFB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HYFB_ECOLI helixturnhelix swissprot:HYFB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HYFB_ECOLI hmoment swissprot:HYFB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HYFB_ECOLI iep swissprot:HYFB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HYFB_ECOLI inforesidue swissprot:HYFB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HYFB_ECOLI octanol swissprot:HYFB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HYFB_ECOLI pepcoil swissprot:HYFB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HYFB_ECOLI pepdigest swissprot:HYFB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HYFB_ECOLI pepinfo swissprot:HYFB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HYFB_ECOLI pepnet swissprot:HYFB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HYFB_ECOLI pepstats swissprot:HYFB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HYFB_ECOLI pepwheel swissprot:HYFB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HYFB_ECOLI pepwindow swissprot:HYFB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HYFB_ECOLI sigcleave swissprot:HYFB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HYFB_ECOLI ## Database ID URL or Descriptions # AltName NNR_ECOLI ADP-dependent NAD(P)HX dehydratase # AltName NNR_ECOLI ADP-dependent NAD(P)HX dehydratase # AltName NNR_ECOLI NAD(P)HX epimerase # AltName NNR_ECOLI Nicotinamide nucleotide repair protein # AltName NNR_ECOLI Nicotinamide nucleotide repair protein # BIOPHYSICOCHEMICAL PROPERTIES NNR_ECOLI Kinetic parameters KM=1.2 uM for (S)-NADHX {ECO 0000269|PubMed 21994945}; KM=0.86 uM for (S)-NADPHX {ECO 0000269|PubMed 21994945}; KM=3.6 uM for ADP {ECO 0000269|PubMed 21994945}; Vmax=0.62 umol/min/mg enzyme toward (S)-NADHX {ECO 0000269|PubMed 21994945}; Vmax=0.88 umol/min/mg enzyme toward (S)-NADPHX {ECO 0000269|PubMed 21994945}; Vmax=0.6 umol/min/mg enzyme toward ADP {ECO 0000269|PubMed 21994945}; # BioGrid 4262704 118 # CATALYTIC ACTIVITY (6R)-6-beta-hydroxy-1,4,5,6- tetrahydronicotinamide-adenine dinucleotide = (6S)-6-beta-hydroxy- 1,4,5,6-tetrahydronicotinamide-adenine dinucleotide. {ECO:0000269|PubMed 21994945}. # CATALYTIC ACTIVITY (6R)-6-beta-hydroxy-1,4,5,6- tetrahydronicotinamide-adenine dinucleotide phosphate = (6S)-6- beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate. {ECO:0000269|PubMed 21994945}. # CATALYTIC ACTIVITY ADP + (6S)-6-beta-hydroxy-1,4,5,6- tetrahydronicotinamide adenine-dinucleotide = AMP + phosphate + NADH. {ECO:0000269|PubMed 21994945}. # CATALYTIC ACTIVITY ADP + (6S)-6-beta-hydroxy-1,4,5,6- tetrahydronicotinamide adenine-dinucleotide phosphate = AMP + phosphate + NADPH. {ECO:0000269|PubMed 21994945}. # CDD cd01171 YXKO-related # COFACTOR NNR_ECOLI Name=K(+); Xref=ChEBI CHEBI 29103; Evidence={ECO 0000250}; Note=Binds 1 potassium ion per subunit. {ECO 0000250}; # EcoGene EG11758 yjeF # FUNCTION NNR_ECOLI Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. {ECO 0000269|PubMed 21994945}. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0052855 ADP-dependent NAD(P)H-hydrate dehydratase activity; IDA:EcoCyc. # GO_function GO:0052856 NADHX epimerase activity; IDA:EcoCyc. # GO_function GO:0052857 NADPHX epimerase activity; IDA:EcoCyc. # GO_process GO:0008152 metabolic process; IEA:UniProtKB-KW. # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # Gene3D 3.40.1190.20 -; 1. # Gene3D 3.40.50.10260 -; 1. # HAMAP MF_01965 NADHX_dehydratase # HAMAP MF_01966 NADHX_epimerase # IntAct P31806 9 # InterPro IPR000631 CARKD # InterPro IPR004443 YjeF_N_dom # InterPro IPR017953 Carbohydrate_kinase_pred_CS # InterPro IPR029056 Ribokinase-like # InterPro IPR030677 Nnr # Organism NNR_ECOLI Escherichia coli (strain K12) # PATRIC 32123907 VBIEscCol129921_4298 # PIR S56392 S56392 # PIRSF PIRSF017184 Nnr # PROSITE PS01049 YJEF_C_1 # PROSITE PS01050 YJEF_C_2 # PROSITE PS51383 YJEF_C_3 # PROSITE PS51385 YJEF_N # Pfam PF01256 Carb_kinase # Pfam PF03853 YjeF_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NNR_ECOLI ADP-dependent (S)-NAD(P)H-hydrate dehydratase # RecName NNR_ECOLI Bifunctional NAD(P)H-hydrate repair enzyme Nnr # RecName NNR_ECOLI NAD(P)H-hydrate epimerase # RefSeq NP_418588 NC_000913.3 # SIMILARITY Contains 1 YjeF C-terminal domain. {ECO 0000305}. # SIMILARITY Contains 1 YjeF N-terminal domain. {ECO 0000305}. # SIMILARITY In the C-terminal section; belongs to the NnrD/CARKD family. {ECO 0000305}. # SIMILARITY In the N-terminal section; belongs to the NnrE/AIBP family. {ECO 0000305}. # SUPFAM SSF53613 SSF53613 # SUPFAM SSF64153 SSF64153 # TIGRFAMs TIGR00196 yjeF_cterm # TIGRFAMs TIGR00197 yjeF_nterm # eggNOG COG0062 LUCA # eggNOG COG0063 LUCA # eggNOG ENOG4105DR1 Bacteria BLAST swissprot:NNR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NNR_ECOLI BioCyc ECOL316407:JW4125-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4125-MONOMER BioCyc EcoCyc:EG11758-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11758-MONOMER BioCyc MetaCyc:EG11758-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11758-MONOMER DIP DIP-12572N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12572N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.C111.310847 http://dx.doi.org/10.1074/jbc.C111.310847 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1111/j.1365-2958.1994.tb00300.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb00300.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.1.136 http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.136 EC_number EC:5.1.99.6 http://www.genome.jp/dbget-bin/www_bget?EC:5.1.99.6 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19346 http://www.ebi.ac.uk/ena/data/view/L19346 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 4.2.1.136 http://enzyme.expasy.org/EC/4.2.1.136 ENZYME 5.1.99.6 http://enzyme.expasy.org/EC/5.1.99.6 EchoBASE EB1708 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1708 EcoGene EG11758 http://www.ecogene.org/geneInfo.php?eg_id=EG11758 EnsemblBacteria AAC77124 http://www.ensemblgenomes.org/id/AAC77124 EnsemblBacteria AAC77124 http://www.ensemblgenomes.org/id/AAC77124 EnsemblBacteria BAE78168 http://www.ensemblgenomes.org/id/BAE78168 EnsemblBacteria BAE78168 http://www.ensemblgenomes.org/id/BAE78168 EnsemblBacteria BAE78168 http://www.ensemblgenomes.org/id/BAE78168 EnsemblBacteria b4167 http://www.ensemblgenomes.org/id/b4167 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0052855 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052855 GO_function GO:0052856 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052856 GO_function GO:0052857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052857 GO_process GO:0008152 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008152 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.1190.20 http://www.cathdb.info/version/latest/superfamily/3.40.1190.20 Gene3D 3.40.50.10260 http://www.cathdb.info/version/latest/superfamily/3.40.50.10260 GeneID 948685 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948685 HAMAP MF_01965 http://hamap.expasy.org/unirule/MF_01965 HAMAP MF_01966 http://hamap.expasy.org/unirule/MF_01966 HOGENOM HOG000228406 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000228406&db=HOGENOM6 InParanoid P31806 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31806 IntAct P31806 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31806* IntEnz 4.2.1.136 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.136 IntEnz 5.1.99.6 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.1.99.6 InterPro IPR000631 http://www.ebi.ac.uk/interpro/entry/IPR000631 InterPro IPR004443 http://www.ebi.ac.uk/interpro/entry/IPR004443 InterPro IPR017953 http://www.ebi.ac.uk/interpro/entry/IPR017953 InterPro IPR029056 http://www.ebi.ac.uk/interpro/entry/IPR029056 InterPro IPR030677 http://www.ebi.ac.uk/interpro/entry/IPR030677 KEGG_Gene ecj:JW4125 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4125 KEGG_Gene eco:b4167 http://www.genome.jp/dbget-bin/www_bget?eco:b4167 MINT MINT-1242763 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1242763 OMA KGDHGRV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KGDHGRV PROSITE PS01049 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01049 PROSITE PS01050 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01050 PROSITE PS51383 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51383 PROSITE PS51385 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51385 PSORT swissprot:NNR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NNR_ECOLI PSORT-B swissprot:NNR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NNR_ECOLI PSORT2 swissprot:NNR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NNR_ECOLI Pfam PF01256 http://pfam.xfam.org/family/PF01256 Pfam PF03853 http://pfam.xfam.org/family/PF03853 Phobius swissprot:NNR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NNR_ECOLI PhylomeDB P31806 http://phylomedb.org/?seqid=P31806 ProteinModelPortal P31806 http://www.proteinmodelportal.org/query/uniprot/P31806 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21994945 http://www.ncbi.nlm.nih.gov/pubmed/21994945 PubMed 7511774 http://www.ncbi.nlm.nih.gov/pubmed/7511774 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418588 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418588 SMR P31806 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31806 STRING 511145.b4167 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4167&targetmode=cogs SUPFAM SSF53613 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53613 SUPFAM SSF64153 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF64153 TIGRFAMs TIGR00196 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00196 TIGRFAMs TIGR00197 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00197 UniProtKB NNR_ECOLI http://www.uniprot.org/uniprot/NNR_ECOLI UniProtKB-AC P31806 http://www.uniprot.org/uniprot/P31806 charge swissprot:NNR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NNR_ECOLI eggNOG COG0062 http://eggnogapi.embl.de/nog_data/html/tree/COG0062 eggNOG COG0063 http://eggnogapi.embl.de/nog_data/html/tree/COG0063 eggNOG ENOG4105DR1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DR1 epestfind swissprot:NNR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NNR_ECOLI garnier swissprot:NNR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NNR_ECOLI helixturnhelix swissprot:NNR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NNR_ECOLI hmoment swissprot:NNR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NNR_ECOLI iep swissprot:NNR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NNR_ECOLI inforesidue swissprot:NNR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NNR_ECOLI octanol swissprot:NNR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NNR_ECOLI pepcoil swissprot:NNR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NNR_ECOLI pepdigest swissprot:NNR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NNR_ECOLI pepinfo swissprot:NNR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NNR_ECOLI pepnet swissprot:NNR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NNR_ECOLI pepstats swissprot:NNR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NNR_ECOLI pepwheel swissprot:NNR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NNR_ECOLI pepwindow swissprot:NNR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NNR_ECOLI sigcleave swissprot:NNR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NNR_ECOLI ## Database ID URL or Descriptions # AltName 3-(3-hydroxy-phenyl)propionate H(+) symporter # BioGrid 4261625 23 # CDD cd06174 MFS # DISRUPTION PHENOTYPE Deletion mutant loses the ability to utilize 3HPP at pH 8.2. {ECO:0000269|PubMed 23934492}. # EcoGene EG13293 mhpT # FUNCTION MHPT_ECOLI Uptake of 3-(3-hydroxyphenyl)propionate (3HPP) across the cytoplasmic membrane. Transport is driven by the proton motive force. Does not transport benzoate, 3-hydroxybenzoate or gentisate. {ECO 0000269|PubMed 23934492}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IBA:GO_Central. # GO_function GO:0015293 symporter activity; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # INDUCTION Induced by 3HPP. {ECO:0000269|PubMed 23934492}. # InterPro IPR005829 Sugar_transporter_CS # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # KEGG_Brite ko02000 Transporters # Organism MHPT_ECOLI Escherichia coli (strain K12) # PATRIC 32115843 VBIEscCol129921_0363 # PIR A64763 A64763 # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MHPT_ECOLI 3-(3-hydroxy-phenyl)propionate transporter # RefSeq NP_414887 NC_000913.3 # RefSeq WP_000107627 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18077.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=D85613; Type=Frameshift; Positions=105, 163; Evidence={ECO 0000305}; # SIMILARITY Belongs to the major facilitator superfamily. Aromatic acid:H(+) symporter (AAHS) (TC 2.A.1.15) family. {ECO 0000305}. # SUBCELLULAR LOCATION MHPT_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 23934492}; Multi- pass membrane protein {ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 23934492}. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.15 the major facilitator superfamily (mfs) # eggNOG ENOG4108SC4 Bacteria # eggNOG ENOG410YW8U LUCA BLAST swissprot:MHPT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MHPT_ECOLI BioCyc ECOL316407:JW5046-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5046-MONOMER BioCyc EcoCyc:MHPT-MONOMER http://biocyc.org/getid?id=EcoCyc:MHPT-MONOMER BioCyc MetaCyc:MHPT-MONOMER http://biocyc.org/getid?id=MetaCyc:MHPT-MONOMER COG COG0477 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0477 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AEM.02110-13 http://dx.doi.org/10.1128/AEM.02110-13 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D85613 http://www.ebi.ac.uk/ena/data/view/D85613 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EMBL X97543 http://www.ebi.ac.uk/ena/data/view/X97543 EchoBASE EB3078 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3078 EcoGene EG13293 http://www.ecogene.org/geneInfo.php?eg_id=EG13293 EnsemblBacteria AAC73456 http://www.ensemblgenomes.org/id/AAC73456 EnsemblBacteria AAC73456 http://www.ensemblgenomes.org/id/AAC73456 EnsemblBacteria BAE76135 http://www.ensemblgenomes.org/id/BAE76135 EnsemblBacteria BAE76135 http://www.ensemblgenomes.org/id/BAE76135 EnsemblBacteria BAE76135 http://www.ensemblgenomes.org/id/BAE76135 EnsemblBacteria b0353 http://www.ensemblgenomes.org/id/b0353 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015293 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GeneID 944997 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944997 HOGENOM HOG000114541 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000114541&db=HOGENOM6 InParanoid P77589 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77589 InterPro IPR005829 http://www.ebi.ac.uk/interpro/entry/IPR005829 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5046 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5046 KEGG_Gene eco:b0353 http://www.genome.jp/dbget-bin/www_bget?eco:b0353 KEGG_Orthology KO:K05819 http://www.genome.jp/dbget-bin/www_bget?KO:K05819 OMA WLWISYF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WLWISYF PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:MHPT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MHPT_ECOLI PSORT-B swissprot:MHPT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MHPT_ECOLI PSORT2 swissprot:MHPT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MHPT_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:MHPT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MHPT_ECOLI PhylomeDB P77589 http://phylomedb.org/?seqid=P77589 ProteinModelPortal P77589 http://www.proteinmodelportal.org/query/uniprot/P77589 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 23934492 http://www.ncbi.nlm.nih.gov/pubmed/23934492 PubMed 9098055 http://www.ncbi.nlm.nih.gov/pubmed/9098055 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414887 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414887 RefSeq WP_000107627 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000107627 STRING 511145.b0353 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0353&targetmode=cogs STRING COG0477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0477&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.15 http://www.tcdb.org/search/result.php?tc=2.A.1.15 UniProtKB MHPT_ECOLI http://www.uniprot.org/uniprot/MHPT_ECOLI UniProtKB-AC P77589 http://www.uniprot.org/uniprot/P77589 charge swissprot:MHPT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MHPT_ECOLI eggNOG ENOG4108SC4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108SC4 eggNOG ENOG410YW8U http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YW8U epestfind swissprot:MHPT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MHPT_ECOLI garnier swissprot:MHPT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MHPT_ECOLI helixturnhelix swissprot:MHPT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MHPT_ECOLI hmoment swissprot:MHPT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MHPT_ECOLI iep swissprot:MHPT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MHPT_ECOLI inforesidue swissprot:MHPT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MHPT_ECOLI octanol swissprot:MHPT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MHPT_ECOLI pepcoil swissprot:MHPT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MHPT_ECOLI pepdigest swissprot:MHPT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MHPT_ECOLI pepinfo swissprot:MHPT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MHPT_ECOLI pepnet swissprot:MHPT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MHPT_ECOLI pepstats swissprot:MHPT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MHPT_ECOLI pepwheel swissprot:MHPT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MHPT_ECOLI pepwindow swissprot:MHPT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MHPT_ECOLI sigcleave swissprot:MHPT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MHPT_ECOLI ## Database ID URL or Descriptions # AltName ENTS_ECOLI Protein p43 # BioGrid 4260903 371 # CDD cd06174 MFS # EcoGene EG11104 entS # FUNCTION ENTS_ECOLI Exports the siderophore enterobactin out of the cell. {ECO 0000269|PubMed 12068807}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0042931 enterobactin transporter activity; IEA:InterPro. # GO_process GO:0006974 cellular response to DNA damage stimulus; IMP:EcoCyc. # GO_process GO:0042930 enterobactin transport; IMP:EcoliWiki. # GO_process GO:0046677 response to antibiotic; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006810 transport # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # HAMAP MF_01436 MFS_EntS # InterPro IPR010290 TM_effector # InterPro IPR020846 MFS_dom # InterPro IPR023722 Enterobactin_exp_EntS # KEGG_Brite ko02000 Transporters # Organism ENTS_ECOLI Escherichia coli (strain K12) # PATRIC 32116358 VBIEscCol129921_0619 # PIR S16306 S16306 # PROSITE PS50850 MFS # Pfam PF05977 MFS_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ENTS_ECOLI Enterobactin exporter EntS # RefSeq NP_415123 NC_000913.3 # RefSeq WP_001041786 NZ_LN832404.1 # SIMILARITY Belongs to the major facilitator superfamily. EntS (TC 2.A.1.38) family. {ECO 0000305}. # SUBCELLULAR LOCATION ENTS_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.38 the major facilitator superfamily (mfs) # eggNOG COG0477 LUCA # eggNOG ENOG4105E8G Bacteria BLAST swissprot:ENTS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ENTS_ECOLI BioCyc ECOL316407:JW0583-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0583-MONOMER BioCyc EcoCyc:YBDA-MONOMER http://biocyc.org/getid?id=EcoCyc:YBDA-MONOMER BioCyc MetaCyc:YBDA-MONOMER http://biocyc.org/getid?id=MetaCyc:YBDA-MONOMER COG COG0477 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0477 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2002.02885.x http://dx.doi.org/10.1046/j.1365-2958.2002.02885.x DOI 10.1111/j.1365-2958.1991.tb00787.x http://dx.doi.org/10.1111/j.1365-2958.1991.tb00787.x DOI 10.1111/j.1365-2958.1991.tb00788.x http://dx.doi.org/10.1111/j.1365-2958.1991.tb00788.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EMBL X57470 http://www.ebi.ac.uk/ena/data/view/X57470 EMBL X59402 http://www.ebi.ac.uk/ena/data/view/X59402 EchoBASE EB1096 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1096 EcoGene EG11104 http://www.ecogene.org/geneInfo.php?eg_id=EG11104 EnsemblBacteria AAC73692 http://www.ensemblgenomes.org/id/AAC73692 EnsemblBacteria AAC73692 http://www.ensemblgenomes.org/id/AAC73692 EnsemblBacteria BAE76346 http://www.ensemblgenomes.org/id/BAE76346 EnsemblBacteria BAE76346 http://www.ensemblgenomes.org/id/BAE76346 EnsemblBacteria BAE76346 http://www.ensemblgenomes.org/id/BAE76346 EnsemblBacteria b0591 http://www.ensemblgenomes.org/id/b0591 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0042931 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042931 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0042930 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042930 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 946268 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946268 HAMAP MF_01436 http://hamap.expasy.org/unirule/MF_01436 HOGENOM HOG000183770 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000183770&db=HOGENOM6 InParanoid P24077 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P24077 InterPro IPR010290 http://www.ebi.ac.uk/interpro/entry/IPR010290 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 InterPro IPR023722 http://www.ebi.ac.uk/interpro/entry/IPR023722 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0583 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0583 KEGG_Gene eco:b0591 http://www.genome.jp/dbget-bin/www_bget?eco:b0591 KEGG_Orthology KO:K08225 http://www.genome.jp/dbget-bin/www_bget?KO:K08225 OMA LLGIWDG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LLGIWDG PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:ENTS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ENTS_ECOLI PSORT-B swissprot:ENTS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ENTS_ECOLI PSORT2 swissprot:ENTS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ENTS_ECOLI Pfam PF05977 http://pfam.xfam.org/family/PF05977 Phobius swissprot:ENTS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ENTS_ECOLI PhylomeDB P24077 http://phylomedb.org/?seqid=P24077 ProteinModelPortal P24077 http://www.proteinmodelportal.org/query/uniprot/P24077 PubMed 12068807 http://www.ncbi.nlm.nih.gov/pubmed/12068807 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1787794 http://www.ncbi.nlm.nih.gov/pubmed/1787794 PubMed 1838574 http://www.ncbi.nlm.nih.gov/pubmed/1838574 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415123 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415123 RefSeq WP_001041786 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001041786 STRING 511145.b0591 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0591&targetmode=cogs STRING COG0477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0477&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.38 http://www.tcdb.org/search/result.php?tc=2.A.1.38 UniProtKB ENTS_ECOLI http://www.uniprot.org/uniprot/ENTS_ECOLI UniProtKB-AC P24077 http://www.uniprot.org/uniprot/P24077 charge swissprot:ENTS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ENTS_ECOLI eggNOG COG0477 http://eggnogapi.embl.de/nog_data/html/tree/COG0477 eggNOG ENOG4105E8G http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E8G epestfind swissprot:ENTS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ENTS_ECOLI garnier swissprot:ENTS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ENTS_ECOLI helixturnhelix swissprot:ENTS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ENTS_ECOLI hmoment swissprot:ENTS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ENTS_ECOLI iep swissprot:ENTS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ENTS_ECOLI inforesidue swissprot:ENTS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ENTS_ECOLI octanol swissprot:ENTS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ENTS_ECOLI pepcoil swissprot:ENTS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ENTS_ECOLI pepdigest swissprot:ENTS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ENTS_ECOLI pepinfo swissprot:ENTS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ENTS_ECOLI pepnet swissprot:ENTS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ENTS_ECOLI pepstats swissprot:ENTS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ENTS_ECOLI pepwheel swissprot:ENTS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ENTS_ECOLI pepwindow swissprot:ENTS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ENTS_ECOLI sigcleave swissprot:ENTS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ENTS_ECOLI ## Database ID URL or Descriptions # AltName Cysteine sulfinate desulfinase {ECO:0000303|PubMed 9278392} # AltName Selenocysteine lyase {ECO:0000303|PubMed 9278392} # BIOPHYSICOCHEMICAL PROPERTIES CSDA_ECOLI Kinetic parameters KM=0.24 mM for L-cysteine sulfinate {ECO 0000269|PubMed 9278392}; KM=1.0 mM for L-selenocysteine {ECO 0000269|PubMed 9278392}; KM=35 mM for L-cysteine {ECO 0000269|PubMed 9278392}; KM=3.3 mM for L-cystine {ECO 0000269|PubMed 9278392}; Vmax=20 umol/min/mg enzyme with L-cysteine sulfinate as substrate {ECO 0000269|PubMed 9278392}; Vmax=7.4 umol/min/mg enzyme with L-selenocysteine as substrate {ECO 0000269|PubMed 9278392}; Vmax=3.4 umol/min/mg enzyme with L-cysteine as substrate {ECO 0000269|PubMed 9278392}; Vmax=0.017 umol/min/mg enzyme with L-cystine as substrate {ECO 0000269|PubMed 9278392}; pH dependence Optimum pH is around 7.0 and 7.5 for the removal of selenium and sulfur atoms from L-selenocysteine and L-cysteine, respectively. {ECO 0000269|PubMed 9278392}; # BioGrid 4261122 584 # CATALYTIC ACTIVITY CSDA_ECOLI L-cysteine + acceptor = L-alanine + S- sulfanyl-acceptor. {ECO 0000269|PubMed 15901727, ECO 0000269|PubMed 9278392}. # CATALYTIC ACTIVITY CSDA_ECOLI L-selenocysteine + reduced acceptor = selenide + L-alanine + acceptor. {ECO 0000269|PubMed 15901727, ECO 0000269|PubMed 9278392}. # COFACTOR CSDA_ECOLI Name=pyridoxal 5'-phosphate; Xref=ChEBI CHEBI 597326; Evidence={ECO 0000269|PubMed 15901727, ECO 0000269|PubMed 9278392}; # DISRUPTION PHENOTYPE CSDA_ECOLI Cells lacking this gene display a high decrease in the level of ct(6)A modification in tRNAs, and show the t(6)A modification instead. They also exhibit a fitness defect, are unable to swim, and are more resistant to the norfloxacin antibiotic than the wild-type. {ECO 0000269|PubMed 20054882, ECO 0000269|PubMed 23242255}. # ENZYME REGULATION Cysteine desulfurase activity is increased 2- fold in the presence of CsdE. {ECO:0000269|PubMed 15901727}. # EcoGene EG13082 csdA # FUNCTION CSDA_ECOLI Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine, and transiently retains the released sulfur atom on a cysteine residue, in the form of a persulfide. Can also desulfinate L-cysteine sulfinate, which is the best substrate of the enzyme. Functions as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate. Seems to participate in Fe/S biogenesis by recruiting the SufBCD- SufE proteins. Transfers sulfur to CsdE that increases the cysteine desulfurase activity of CsdA. Can also transfer sulfur directly to TcdA/CsdL in vitro. Appears to support the function of TcdA in the generation of cyclic threonylcarbamoyladenosine at position 37 (ct(6)A37) in tRNAs that read codons beginning with adenine. {ECO 0000269|PubMed 10829016, ECO 0000269|PubMed 15901727, ECO 0000269|PubMed 20054882, ECO 0000269|PubMed 23242255, ECO 0000269|PubMed 9278392}. # GO_function GO:0009000 selenocysteine lyase activity; IEA:UniProtKB-EC. # GO_function GO:0016783 sulfurtransferase activity; IDA:EcoCyc. # GO_function GO:0030170 pyridoxal phosphate binding; IDA:EcoCyc. # GO_function GO:0031071 cysteine desulfurase activity; IEA:UniProtKB-EC. # GO_process GO:0000096 sulfur amino acid metabolic process; IDA:EcoCyc. # GO_process GO:0016226 iron-sulfur cluster assembly; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.640.10 -; 1. # Gene3D 3.90.1150.10 -; 1. # INDUCTION Induced in persister cells. {ECO:0000269|PubMed 16768798}. # INTERACTION CSDA_ECOLI P0AGF2 csdE; NbExp=8; IntAct=EBI-545660, EBI-1130454; # IntAct Q46925 7 # InterPro IPR000192 Aminotrans_V_dom # InterPro IPR015421 PyrdxlP-dep_Trfase_major_sub1 # InterPro IPR015422 PyrdxlP-dep_Trfase_major_sub2 # InterPro IPR015424 PyrdxlP-dep_Trfase # InterPro IPR020578 Aminotrans_V_PyrdxlP_BS # InterPro IPR022471 Cys_desulphurase_CdsA # KEGG_Brite ko01000 Enzymes # Organism CSDA_ECOLI Escherichia coli (strain K12) # PATRIC 32121036 VBIEscCol129921_2910 # PDB 4LW2 X-ray; 1.80 A; A/B/C=1-401 # PDB 4LW4 X-ray; 2.01 A; A/B=1-401 # PIR F65063 F65063 # PROSITE PS00595 AA_TRANSFER_CLASS_5 # Pfam PF00266 Aminotran_5 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Cysteine desulfurase CsdA {ECO:0000303|PubMed 9278392} # RefSeq NP_417290 NC_000913.3 # RefSeq WP_001300698 NZ_LN832404.1 # SIMILARITY Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily. {ECO 0000305}. # SUBUNIT Homodimer. Forms a heterodimer with CsdE. {ECO:0000269|PubMed 15901727}. # SUPFAM SSF53383 SSF53383 # TIGRFAMs TIGR03392 FeS_syn_CsdA # eggNOG COG0520 LUCA # eggNOG ENOG4105C9B Bacteria BLAST swissprot:CSDA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CSDA_ECOLI BioCyc ECOL316407:JW2781-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2781-MONOMER BioCyc EcoCyc:G7454-MONOMER http://biocyc.org/getid?id=EcoCyc:G7454-MONOMER BioCyc MetaCyc:G7454-MONOMER http://biocyc.org/getid?id=MetaCyc:G7454-MONOMER COG COG0520 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0520 DIP DIP-9323N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9323N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nchembio.1137 http://dx.doi.org/10.1038/nchembio.1137 DOI 10.1074/jbc.272.36.22417 http://dx.doi.org/10.1074/jbc.272.36.22417 DOI 10.1074/jbc.M000926200 http://dx.doi.org/10.1074/jbc.M000926200 DOI 10.1074/jbc.M504067200 http://dx.doi.org/10.1074/jbc.M504067200 DOI 10.1093/oxfordjournals.jbchem.a022641 http://dx.doi.org/10.1093/oxfordjournals.jbchem.a022641 DOI 10.1111/j.1365-2958.2009.06954.x http://dx.doi.org/10.1111/j.1365-2958.2009.06954.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1186/1471-2180-6-53 http://dx.doi.org/10.1186/1471-2180-6-53 EC_number EC:2.8.1.7 {ECO:0000269|PubMed:15901727, ECO:0000269|PubMed:9278392} http://www.genome.jp/dbget-bin/www_bget?EC:2.8.1.7 {ECO:0000269|PubMed:15901727, ECO:0000269|PubMed:9278392} EC_number EC:4.4.1.- http://www.genome.jp/dbget-bin/www_bget?EC:4.4.1.- EC_number EC:4.4.1.16 {ECO:0000269|PubMed:15901727, ECO:0000269|PubMed:9278392} http://www.genome.jp/dbget-bin/www_bget?EC:4.4.1.16 {ECO:0000269|PubMed:15901727, ECO:0000269|PubMed:9278392} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL AX000470 http://www.ebi.ac.uk/ena/data/view/AX000470 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 ENZYME 2.8.1.7 {ECO:0000269|PubMed:15901727, ECO:0000269|PubMed:9278392} http://enzyme.expasy.org/EC/2.8.1.7 {ECO:0000269|PubMed:15901727, ECO:0000269|PubMed:9278392} ENZYME 4.4.1.- http://enzyme.expasy.org/EC/4.4.1.- ENZYME 4.4.1.16 {ECO:0000269|PubMed:15901727, ECO:0000269|PubMed:9278392} http://enzyme.expasy.org/EC/4.4.1.16 {ECO:0000269|PubMed:15901727, ECO:0000269|PubMed:9278392} EchoBASE EB2891 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2891 EcoGene EG13082 http://www.ecogene.org/geneInfo.php?eg_id=EG13082 EnsemblBacteria AAC75852 http://www.ensemblgenomes.org/id/AAC75852 EnsemblBacteria AAC75852 http://www.ensemblgenomes.org/id/AAC75852 EnsemblBacteria BAE76882 http://www.ensemblgenomes.org/id/BAE76882 EnsemblBacteria BAE76882 http://www.ensemblgenomes.org/id/BAE76882 EnsemblBacteria BAE76882 http://www.ensemblgenomes.org/id/BAE76882 EnsemblBacteria b2810 http://www.ensemblgenomes.org/id/b2810 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0009000 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009000 GO_function GO:0016783 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016783 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_function GO:0031071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031071 GO_process GO:0000096 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000096 GO_process GO:0016226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016226 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.640.10 http://www.cathdb.info/version/latest/superfamily/3.40.640.10 Gene3D 3.90.1150.10 http://www.cathdb.info/version/latest/superfamily/3.90.1150.10 GeneID 947275 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947275 HOGENOM HOG000017511 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000017511&db=HOGENOM6 InParanoid Q46925 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46925 IntAct Q46925 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46925* IntEnz 2.8.1.7 {ECO:0000269|PubMed:15901727, ECO:0000269|PubMed:9278392} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.8.1.7 {ECO:0000269|PubMed:15901727, ECO:0000269|PubMed:9278392} IntEnz 4.4.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.4.1 IntEnz 4.4.1.16 {ECO:0000269|PubMed:15901727, ECO:0000269|PubMed:9278392} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.4.1.16 {ECO:0000269|PubMed:15901727, ECO:0000269|PubMed:9278392} InterPro IPR000192 http://www.ebi.ac.uk/interpro/entry/IPR000192 InterPro IPR015421 http://www.ebi.ac.uk/interpro/entry/IPR015421 InterPro IPR015422 http://www.ebi.ac.uk/interpro/entry/IPR015422 InterPro IPR015424 http://www.ebi.ac.uk/interpro/entry/IPR015424 InterPro IPR020578 http://www.ebi.ac.uk/interpro/entry/IPR020578 InterPro IPR022471 http://www.ebi.ac.uk/interpro/entry/IPR022471 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2781 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2781 KEGG_Gene eco:b2810 http://www.genome.jp/dbget-bin/www_bget?eco:b2810 KEGG_Orthology KO:K01766 http://www.genome.jp/dbget-bin/www_bget?KO:K01766 OMA PYNNQQD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PYNNQQD PDB 4LW2 http://www.ebi.ac.uk/pdbe-srv/view/entry/4LW2 PDB 4LW4 http://www.ebi.ac.uk/pdbe-srv/view/entry/4LW4 PDBsum 4LW2 http://www.ebi.ac.uk/pdbsum/4LW2 PDBsum 4LW4 http://www.ebi.ac.uk/pdbsum/4LW4 PROSITE PS00595 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00595 PSORT swissprot:CSDA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CSDA_ECOLI PSORT-B swissprot:CSDA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CSDA_ECOLI PSORT2 swissprot:CSDA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CSDA_ECOLI Pfam PF00266 http://pfam.xfam.org/family/PF00266 Phobius swissprot:CSDA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CSDA_ECOLI PhylomeDB Q46925 http://phylomedb.org/?seqid=Q46925 ProteinModelPortal Q46925 http://www.proteinmodelportal.org/query/uniprot/Q46925 PubMed 10739946 http://www.ncbi.nlm.nih.gov/pubmed/10739946 PubMed 10829016 http://www.ncbi.nlm.nih.gov/pubmed/10829016 PubMed 15901727 http://www.ncbi.nlm.nih.gov/pubmed/15901727 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16768798 http://www.ncbi.nlm.nih.gov/pubmed/16768798 PubMed 20054882 http://www.ncbi.nlm.nih.gov/pubmed/20054882 PubMed 23242255 http://www.ncbi.nlm.nih.gov/pubmed/23242255 PubMed 9278392 http://www.ncbi.nlm.nih.gov/pubmed/9278392 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417290 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417290 RefSeq WP_001300698 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300698 SMR Q46925 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46925 STRING 511145.b2810 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2810&targetmode=cogs STRING COG0520 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0520&targetmode=cogs SUPFAM SSF53383 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53383 TIGRFAMs TIGR03392 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03392 UniProtKB CSDA_ECOLI http://www.uniprot.org/uniprot/CSDA_ECOLI UniProtKB-AC Q46925 http://www.uniprot.org/uniprot/Q46925 charge swissprot:CSDA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CSDA_ECOLI eggNOG COG0520 http://eggnogapi.embl.de/nog_data/html/tree/COG0520 eggNOG ENOG4105C9B http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C9B epestfind swissprot:CSDA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CSDA_ECOLI garnier swissprot:CSDA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CSDA_ECOLI helixturnhelix swissprot:CSDA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CSDA_ECOLI hmoment swissprot:CSDA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CSDA_ECOLI iep swissprot:CSDA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CSDA_ECOLI inforesidue swissprot:CSDA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CSDA_ECOLI octanol swissprot:CSDA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CSDA_ECOLI pepcoil swissprot:CSDA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CSDA_ECOLI pepdigest swissprot:CSDA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CSDA_ECOLI pepinfo swissprot:CSDA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CSDA_ECOLI pepnet swissprot:CSDA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CSDA_ECOLI pepstats swissprot:CSDA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CSDA_ECOLI pepwheel swissprot:CSDA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CSDA_ECOLI pepwindow swissprot:CSDA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CSDA_ECOLI sigcleave swissprot:CSDA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CSDA_ECOLI ## Database ID URL or Descriptions # BioGrid 4263193 12 # EcoGene EG13916 ycjS # GO_function GO:0016491 oxidoreductase activity; IBA:GO_Central. # GO_process GO:0055114 oxidation-reduction process; IBA:GO_Central. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.720 -; 1. # InterPro IPR000683 Oxidoreductase_N # InterPro IPR004104 OxRdtase_C # InterPro IPR016040 NAD(P)-bd_dom # Organism YCJS_ECOLI Escherichia coli (strain K12) # PATRIC 32117902 VBIEscCol129921_1371 # PIR F64880 F64880 # Pfam PF01408 GFO_IDH_MocA # Pfam PF02894 GFO_IDH_MocA_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCJS_ECOLI Uncharacterized oxidoreductase YcjS # RefSeq NP_415831 NC_000913.3 # RefSeq WP_001395397 NZ_LN832404.1 # SIMILARITY Belongs to the Gfo/Idh/MocA family. {ECO 0000305}. # SUPFAM SSF51735 SSF51735 # eggNOG COG0673 LUCA # eggNOG ENOG4105CK5 Bacteria BLAST swissprot:YCJS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCJS_ECOLI BioCyc ECOL316407:JW1308-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1308-MONOMER BioCyc EcoCyc:G6653-MONOMER http://biocyc.org/getid?id=EcoCyc:G6653-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- EchoBASE EB3675 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3675 EcoGene EG13916 http://www.ecogene.org/geneInfo.php?eg_id=EG13916 EnsemblBacteria AAC74397 http://www.ensemblgenomes.org/id/AAC74397 EnsemblBacteria AAC74397 http://www.ensemblgenomes.org/id/AAC74397 EnsemblBacteria BAA14890 http://www.ensemblgenomes.org/id/BAA14890 EnsemblBacteria BAA14890 http://www.ensemblgenomes.org/id/BAA14890 EnsemblBacteria BAA14890 http://www.ensemblgenomes.org/id/BAA14890 EnsemblBacteria b1315 http://www.ensemblgenomes.org/id/b1315 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_process GO:0055114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 948589 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948589 HOGENOM HOG000227444 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000227444&db=HOGENOM6 InParanoid P77503 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77503 IntAct P77503 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77503* IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR000683 http://www.ebi.ac.uk/interpro/entry/IPR000683 InterPro IPR004104 http://www.ebi.ac.uk/interpro/entry/IPR004104 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 KEGG_Gene ecj:JW1308 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1308 KEGG_Gene eco:b1315 http://www.genome.jp/dbget-bin/www_bget?eco:b1315 OMA MNVEFCG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MNVEFCG PSORT swissprot:YCJS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCJS_ECOLI PSORT-B swissprot:YCJS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCJS_ECOLI PSORT2 swissprot:YCJS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCJS_ECOLI Pfam PF01408 http://pfam.xfam.org/family/PF01408 Pfam PF02894 http://pfam.xfam.org/family/PF02894 Phobius swissprot:YCJS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCJS_ECOLI PhylomeDB P77503 http://phylomedb.org/?seqid=P77503 ProteinModelPortal P77503 http://www.proteinmodelportal.org/query/uniprot/P77503 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415831 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415831 RefSeq WP_001395397 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001395397 SMR P77503 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77503 STRING 511145.b1315 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1315&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB YCJS_ECOLI http://www.uniprot.org/uniprot/YCJS_ECOLI UniProtKB-AC P77503 http://www.uniprot.org/uniprot/P77503 charge swissprot:YCJS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCJS_ECOLI eggNOG COG0673 http://eggnogapi.embl.de/nog_data/html/tree/COG0673 eggNOG ENOG4105CK5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CK5 epestfind swissprot:YCJS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCJS_ECOLI garnier swissprot:YCJS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCJS_ECOLI helixturnhelix swissprot:YCJS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCJS_ECOLI hmoment swissprot:YCJS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCJS_ECOLI iep swissprot:YCJS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCJS_ECOLI inforesidue swissprot:YCJS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCJS_ECOLI octanol swissprot:YCJS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCJS_ECOLI pepcoil swissprot:YCJS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCJS_ECOLI pepdigest swissprot:YCJS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCJS_ECOLI pepinfo swissprot:YCJS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCJS_ECOLI pepnet swissprot:YCJS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCJS_ECOLI pepstats swissprot:YCJS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCJS_ECOLI pepwheel swissprot:YCJS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCJS_ECOLI pepwindow swissprot:YCJS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCJS_ECOLI sigcleave swissprot:YCJS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCJS_ECOLI ## Database ID URL or Descriptions # AltName FOCB_ECOLI Formate channel 2 # BioGrid 4261432 6 # EcoGene EG14220 focB # FUNCTION FOCB_ECOLI Involved in the bidirectional transport of formate. {ECO 0000250}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0015499 formate transmembrane transporter activity; IBA:GO_Central. # GO_process GO:0015724 formate transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # Gene3D 1.20.1080.10 -; 1. # InterPro IPR000292 For/NO2_transpt # InterPro IPR023271 Aquaporin-like # InterPro IPR024002 For/NO2_transpt_CS # KEGG_Brite ko02000 Transporters # Organism FOCB_ECOLI Escherichia coli (strain K12) # PATRIC 32120371 VBIEscCol129921_2588 # PIR C65025 C65025 # PROSITE PS01005 FORMATE_NITRITE_TP_1 # PROSITE PS01006 FORMATE_NITRITE_TP_2 # Pfam PF01226 Form_Nir_trans # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FOCB_ECOLI Probable formate transporter 2 # RefSeq NP_416987 NC_000913.3 # RefSeq WP_001244734 NZ_LN832404.1 # SIMILARITY Belongs to the FNT transporter (TC 2.A.44) family. {ECO 0000305}. # SUBCELLULAR LOCATION FOCB_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # TCDB 1.A.16.1 the formate-nitrite transporter (fnt) family # TIGRFAMs TIGR00790 fnt # eggNOG COG2116 LUCA # eggNOG ENOG4105TMB Bacteria BLAST swissprot:FOCB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FOCB_ECOLI BioCyc ECOL316407:JW2477-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2477-MONOMER BioCyc EcoCyc:FOCB-MONOMER http://biocyc.org/getid?id=EcoCyc:FOCB-MONOMER COG COG2116 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2116 DIP DIP-9671N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9671N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M63654 http://www.ebi.ac.uk/ena/data/view/M63654 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3972 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3972 EcoGene EG14220 http://www.ecogene.org/geneInfo.php?eg_id=EG14220 EnsemblBacteria AAC75545 http://www.ensemblgenomes.org/id/AAC75545 EnsemblBacteria AAC75545 http://www.ensemblgenomes.org/id/AAC75545 EnsemblBacteria BAA16381 http://www.ensemblgenomes.org/id/BAA16381 EnsemblBacteria BAA16381 http://www.ensemblgenomes.org/id/BAA16381 EnsemblBacteria BAA16381 http://www.ensemblgenomes.org/id/BAA16381 EnsemblBacteria b2492 http://www.ensemblgenomes.org/id/b2492 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015499 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015499 GO_process GO:0015724 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015724 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 1.20.1080.10 http://www.cathdb.info/version/latest/superfamily/1.20.1080.10 GeneID 949032 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949032 HOGENOM HOG000271393 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000271393&db=HOGENOM6 InParanoid P77733 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77733 IntAct P77733 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77733* InterPro IPR000292 http://www.ebi.ac.uk/interpro/entry/IPR000292 InterPro IPR023271 http://www.ebi.ac.uk/interpro/entry/IPR023271 InterPro IPR024002 http://www.ebi.ac.uk/interpro/entry/IPR024002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2477 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2477 KEGG_Gene eco:b2492 http://www.genome.jp/dbget-bin/www_bget?eco:b2492 KEGG_Orthology KO:K03459 http://www.genome.jp/dbget-bin/www_bget?KO:K03459 MINT MINT-1231949 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1231949 OMA KILAIWF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KILAIWF PROSITE PS01005 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01005 PROSITE PS01006 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01006 PSORT swissprot:FOCB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FOCB_ECOLI PSORT-B swissprot:FOCB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FOCB_ECOLI PSORT2 swissprot:FOCB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FOCB_ECOLI Pfam PF01226 http://pfam.xfam.org/family/PF01226 Phobius swissprot:FOCB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FOCB_ECOLI PhylomeDB P77733 http://phylomedb.org/?seqid=P77733 ProteinModelPortal P77733 http://www.proteinmodelportal.org/query/uniprot/P77733 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416987 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416987 RefSeq WP_001244734 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001244734 STRING 511145.b2492 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2492&targetmode=cogs STRING COG2116 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2116&targetmode=cogs TCDB 1.A.16.1 http://www.tcdb.org/search/result.php?tc=1.A.16.1 TIGRFAMs TIGR00790 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00790 UniProtKB FOCB_ECOLI http://www.uniprot.org/uniprot/FOCB_ECOLI UniProtKB-AC P77733 http://www.uniprot.org/uniprot/P77733 charge swissprot:FOCB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FOCB_ECOLI eggNOG COG2116 http://eggnogapi.embl.de/nog_data/html/tree/COG2116 eggNOG ENOG4105TMB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105TMB epestfind swissprot:FOCB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FOCB_ECOLI garnier swissprot:FOCB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FOCB_ECOLI helixturnhelix swissprot:FOCB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FOCB_ECOLI hmoment swissprot:FOCB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FOCB_ECOLI iep swissprot:FOCB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FOCB_ECOLI inforesidue swissprot:FOCB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FOCB_ECOLI octanol swissprot:FOCB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FOCB_ECOLI pepcoil swissprot:FOCB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FOCB_ECOLI pepdigest swissprot:FOCB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FOCB_ECOLI pepinfo swissprot:FOCB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FOCB_ECOLI pepnet swissprot:FOCB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FOCB_ECOLI pepstats swissprot:FOCB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FOCB_ECOLI pepwheel swissprot:FOCB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FOCB_ECOLI pepwindow swissprot:FOCB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FOCB_ECOLI sigcleave swissprot:FOCB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FOCB_ECOLI ## Database ID URL or Descriptions # AltName GREA_ECOLI Transcript cleavage factor GreA # BioGrid 4262064 36 # EcoGene EG10415 greA # FUNCTION GREA_ECOLI Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. # GO_component GO:0005737 cytoplasm; IDA:UniProtKB. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0001108 bacterial-type RNA polymerase holo enzyme binding; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006354 DNA-templated transcription, elongation; IDA:EcoCyc. # GO_process GO:0032784 regulation of DNA-templated transcription, elongation; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.287.180 -; 1. # Gene3D 3.10.50.30 -; 1. # HAMAP MF_00105 GreA_GreB # IntAct P0A6W5 51 # InterPro IPR001437 Tscrpt_elong_fac_GreA/B_C # InterPro IPR006359 Tscrpt_elong_fac_GreA # InterPro IPR018151 TF_GreA/GreB_CS # InterPro IPR022691 Tscrpt_elong_fac_GreA/B_N # InterPro IPR023459 Tscrpt_elong_fac_GreA/B_fam # InterPro IPR028624 Tscrpt_elong_fac_GreA/B # KEGG_Brite ko03021 Transcription machinery # Organism GREA_ECOLI Escherichia coli (strain K12) # PATRIC 32121780 VBIEscCol129921_3274 # PDB 1GRJ X-ray; 2.20 A; A=1-158 # PIR G65108 G65108 # PIRSF PIRSF006092 GreA_GreB # PROSITE PS00829 GREAB_1 # PROSITE PS00830 GREAB_2 # Pfam PF01272 GreA_GreB # Pfam PF03449 GreA_GreB_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GREA_ECOLI Transcription elongation factor GreA # RefSeq NP_417648 NC_000913.3 # RefSeq WP_001148001 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA57982.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the GreA/GreB family. {ECO 0000305}. # SUPFAM SSF46557 SSF46557 # TIGRFAMs TIGR01462 greA # eggNOG COG0782 LUCA # eggNOG ENOG4108UKH Bacteria BLAST swissprot:GREA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GREA_ECOLI BioCyc ECOL316407:JW3148-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3148-MONOMER BioCyc EcoCyc:EG10415-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10415-MONOMER COG COG0782 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0782 DIP DIP-35800N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35800N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/373636a0 http://dx.doi.org/10.1038/373636a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/18.21.6443 http://dx.doi.org/10.1093/nar/18.21.6443 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U01376 http://www.ebi.ac.uk/ena/data/view/U01376 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X54718 http://www.ebi.ac.uk/ena/data/view/X54718 EchoBASE EB0410 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0410 EcoGene EG10415 http://www.ecogene.org/geneInfo.php?eg_id=EG10415 EnsemblBacteria AAC76213 http://www.ensemblgenomes.org/id/AAC76213 EnsemblBacteria AAC76213 http://www.ensemblgenomes.org/id/AAC76213 EnsemblBacteria BAE77225 http://www.ensemblgenomes.org/id/BAE77225 EnsemblBacteria BAE77225 http://www.ensemblgenomes.org/id/BAE77225 EnsemblBacteria BAE77225 http://www.ensemblgenomes.org/id/BAE77225 EnsemblBacteria b3181 http://www.ensemblgenomes.org/id/b3181 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0001108 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001108 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006354 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006354 GO_process GO:0032784 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032784 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.287.180 http://www.cathdb.info/version/latest/superfamily/1.10.287.180 Gene3D 3.10.50.30 http://www.cathdb.info/version/latest/superfamily/3.10.50.30 GeneID 947696 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947696 HAMAP MF_00105 http://hamap.expasy.org/unirule/MF_00105 HOGENOM HOG000241145 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000241145&db=HOGENOM6 InParanoid P0A6W5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6W5 IntAct P0A6W5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6W5* InterPro IPR001437 http://www.ebi.ac.uk/interpro/entry/IPR001437 InterPro IPR006359 http://www.ebi.ac.uk/interpro/entry/IPR006359 InterPro IPR018151 http://www.ebi.ac.uk/interpro/entry/IPR018151 InterPro IPR022691 http://www.ebi.ac.uk/interpro/entry/IPR022691 InterPro IPR023459 http://www.ebi.ac.uk/interpro/entry/IPR023459 InterPro IPR028624 http://www.ebi.ac.uk/interpro/entry/IPR028624 KEGG_Brite ko03021 http://www.genome.jp/dbget-bin/www_bget?ko03021 KEGG_Gene ecj:JW3148 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3148 KEGG_Gene eco:b3181 http://www.genome.jp/dbget-bin/www_bget?eco:b3181 KEGG_Orthology KO:K03624 http://www.genome.jp/dbget-bin/www_bget?KO:K03624 OMA HNEGRIA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HNEGRIA PDB 1GRJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1GRJ PDBsum 1GRJ http://www.ebi.ac.uk/pdbsum/1GRJ PROSITE PS00829 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00829 PROSITE PS00830 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00830 PSORT swissprot:GREA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GREA_ECOLI PSORT-B swissprot:GREA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GREA_ECOLI PSORT2 swissprot:GREA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GREA_ECOLI Pfam PF01272 http://pfam.xfam.org/family/PF01272 Pfam PF03449 http://pfam.xfam.org/family/PF03449 Phobius swissprot:GREA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GREA_ECOLI PhylomeDB P0A6W5 http://phylomedb.org/?seqid=P0A6W5 ProteinModelPortal P0A6W5 http://www.proteinmodelportal.org/query/uniprot/P0A6W5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2243801 http://www.ncbi.nlm.nih.gov/pubmed/2243801 PubMed 7854424 http://www.ncbi.nlm.nih.gov/pubmed/7854424 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417648 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417648 RefSeq WP_001148001 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001148001 SMR P0A6W5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6W5 STRING 511145.b3181 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3181&targetmode=cogs STRING COG0782 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0782&targetmode=cogs SUPFAM SSF46557 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46557 SWISS-2DPAGE P0A6W5 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A6W5 TIGRFAMs TIGR01462 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01462 UniProtKB GREA_ECOLI http://www.uniprot.org/uniprot/GREA_ECOLI UniProtKB-AC P0A6W5 http://www.uniprot.org/uniprot/P0A6W5 charge swissprot:GREA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GREA_ECOLI eggNOG COG0782 http://eggnogapi.embl.de/nog_data/html/tree/COG0782 eggNOG ENOG4108UKH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UKH epestfind swissprot:GREA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GREA_ECOLI garnier swissprot:GREA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GREA_ECOLI helixturnhelix swissprot:GREA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GREA_ECOLI hmoment swissprot:GREA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GREA_ECOLI iep swissprot:GREA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GREA_ECOLI inforesidue swissprot:GREA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GREA_ECOLI octanol swissprot:GREA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GREA_ECOLI pepcoil swissprot:GREA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GREA_ECOLI pepdigest swissprot:GREA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GREA_ECOLI pepinfo swissprot:GREA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GREA_ECOLI pepnet swissprot:GREA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GREA_ECOLI pepstats swissprot:GREA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GREA_ECOLI pepwheel swissprot:GREA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GREA_ECOLI pepwindow swissprot:GREA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GREA_ECOLI sigcleave swissprot:GREA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GREA_ECOLI ## Database ID URL or Descriptions # CAUTION Could be the product of a pseudogene. The gene coding for this protein is interrupted by a hybrid IS2D/IS30C element between amino acids 839 and 840. {ECO 0000305}. # EcoGene EG11307 ydbA # IntAct P33666 8 # InterPro IPR005546 Autotransporte_beta # Organism YDBA_ECOLI Escherichia coli (strain K12) # PROSITE PS51208 AUTOTRANSPORTER # Pfam PF03797 Autotransporter # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDBA_ECOLI Putative uncharacterized protein YdbA # SIMILARITY Contains 1 autotransporter (TC 1.B.12) domain. {ECO:0000255|PROSITE-ProRule PRU00556}. # SUPFAM SSF103515 SSF103515 BLAST swissprot:YDBA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDBA_ECOLI BioCyc EcoCyc:G6722-MONOMER http://biocyc.org/getid?id=EcoCyc:G6722-MONOMER BioCyc EcoCyc:G8204-MONOMER http://biocyc.org/getid?id=EcoCyc:G8204-MONOMER DIP DIP-11631N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11631N DOI 10.1016/0300-9084(91)90166-X http://dx.doi.org/10.1016/0300-9084(91)90166-X DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X62680 http://www.ebi.ac.uk/ena/data/view/X62680 EchoBASE EB1284 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1284 EcoGene EG11307 http://www.ecogene.org/geneInfo.php?eg_id=EG11307 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv HOGENOM HOG000120520 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120520&db=HOGENOM6 InParanoid P33666 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33666 IntAct P33666 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33666* InterPro IPR005546 http://www.ebi.ac.uk/interpro/entry/IPR005546 PROSITE PS51208 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51208 PSORT swissprot:YDBA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDBA_ECOLI PSORT-B swissprot:YDBA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDBA_ECOLI PSORT2 swissprot:YDBA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDBA_ECOLI Pfam PF03797 http://pfam.xfam.org/family/PF03797 Phobius swissprot:YDBA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDBA_ECOLI PhylomeDB P33666 http://phylomedb.org/?seqid=P33666 ProteinModelPortal P33666 http://www.proteinmodelportal.org/query/uniprot/P33666 PubMed 1665988 http://www.ncbi.nlm.nih.gov/pubmed/1665988 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SMR P33666 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33666 SUPFAM SSF103515 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103515 UniProtKB YDBA_ECOLI http://www.uniprot.org/uniprot/YDBA_ECOLI UniProtKB-AC P33666 http://www.uniprot.org/uniprot/P33666 charge swissprot:YDBA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDBA_ECOLI epestfind swissprot:YDBA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDBA_ECOLI garnier swissprot:YDBA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDBA_ECOLI helixturnhelix swissprot:YDBA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDBA_ECOLI hmoment swissprot:YDBA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDBA_ECOLI iep swissprot:YDBA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDBA_ECOLI inforesidue swissprot:YDBA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDBA_ECOLI octanol swissprot:YDBA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDBA_ECOLI pepcoil swissprot:YDBA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDBA_ECOLI pepdigest swissprot:YDBA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDBA_ECOLI pepinfo swissprot:YDBA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDBA_ECOLI pepnet swissprot:YDBA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDBA_ECOLI pepstats swissprot:YDBA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDBA_ECOLI pepwheel swissprot:YDBA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDBA_ECOLI pepwindow swissprot:YDBA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDBA_ECOLI sigcleave swissprot:YDBA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDBA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259967 17 # EcoGene EG12422 ybiJ # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0006950 response to stress # Gene3D 3.30.1660.10 -; 1. # InterPro IPR010854 DUF1471 # InterPro IPR025543 Dodecin-like # Organism YBIJ_ECOLI Escherichia coli (strain K12) # PATRIC 32116807 VBIEscCol129921_0829 # PIR B64817 B64817 # Pfam PF07338 DUF1471 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBIJ_ECOLI Uncharacterized protein YbiJ # RefSeq NP_415323 NC_000913.3 # RefSeq WP_000849301 NZ_LN832404.1 # SIMILARITY Belongs to the BhsA/McbA family. {ECO 0000305}. # SUBCELLULAR LOCATION YBIJ_ECOLI Periplasm {ECO 0000305}. # SUPFAM SSF159871 SSF159871 # eggNOG ENOG4105VR4 Bacteria # eggNOG ENOG41122K9 LUCA BLAST swissprot:YBIJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBIJ_ECOLI BioCyc ECOL316407:JW0787-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0787-MONOMER BioCyc EcoCyc:EG12422-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12422-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1266/jjg.69.1 http://dx.doi.org/10.1266/jjg.69.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L02123 http://www.ebi.ac.uk/ena/data/view/L02123 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2321 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2321 EcoGene EG12422 http://www.ecogene.org/geneInfo.php?eg_id=EG12422 EnsemblBacteria AAC73889 http://www.ensemblgenomes.org/id/AAC73889 EnsemblBacteria AAC73889 http://www.ensemblgenomes.org/id/AAC73889 EnsemblBacteria BAA35468 http://www.ensemblgenomes.org/id/BAA35468 EnsemblBacteria BAA35468 http://www.ensemblgenomes.org/id/BAA35468 EnsemblBacteria BAA35468 http://www.ensemblgenomes.org/id/BAA35468 EnsemblBacteria b0802 http://www.ensemblgenomes.org/id/b0802 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.30.1660.10 http://www.cathdb.info/version/latest/superfamily/3.30.1660.10 GeneID 945433 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945433 HOGENOM HOG000117400 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117400&db=HOGENOM6 InParanoid P0AAX3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAX3 InterPro IPR010854 http://www.ebi.ac.uk/interpro/entry/IPR010854 InterPro IPR025543 http://www.ebi.ac.uk/interpro/entry/IPR025543 KEGG_Gene ecj:JW0787 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0787 KEGG_Gene eco:b0802 http://www.genome.jp/dbget-bin/www_bget?eco:b0802 OMA HATAVIY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HATAVIY PSORT swissprot:YBIJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBIJ_ECOLI PSORT-B swissprot:YBIJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBIJ_ECOLI PSORT2 swissprot:YBIJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBIJ_ECOLI Pfam PF07338 http://pfam.xfam.org/family/PF07338 Phobius swissprot:YBIJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBIJ_ECOLI PhylomeDB P0AAX3 http://phylomedb.org/?seqid=P0AAX3 ProteinModelPortal P0AAX3 http://www.proteinmodelportal.org/query/uniprot/P0AAX3 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8037924 http://www.ncbi.nlm.nih.gov/pubmed/8037924 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415323 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415323 RefSeq WP_000849301 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000849301 SMR P0AAX3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAX3 STRING 511145.b0802 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0802&targetmode=cogs SUPFAM SSF159871 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF159871 UniProtKB YBIJ_ECOLI http://www.uniprot.org/uniprot/YBIJ_ECOLI UniProtKB-AC P0AAX3 http://www.uniprot.org/uniprot/P0AAX3 charge swissprot:YBIJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBIJ_ECOLI eggNOG ENOG4105VR4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VR4 eggNOG ENOG41122K9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41122K9 epestfind swissprot:YBIJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBIJ_ECOLI garnier swissprot:YBIJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBIJ_ECOLI helixturnhelix swissprot:YBIJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBIJ_ECOLI hmoment swissprot:YBIJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBIJ_ECOLI iep swissprot:YBIJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBIJ_ECOLI inforesidue swissprot:YBIJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBIJ_ECOLI octanol swissprot:YBIJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBIJ_ECOLI pepcoil swissprot:YBIJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBIJ_ECOLI pepdigest swissprot:YBIJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBIJ_ECOLI pepinfo swissprot:YBIJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBIJ_ECOLI pepnet swissprot:YBIJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBIJ_ECOLI pepstats swissprot:YBIJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBIJ_ECOLI pepwheel swissprot:YBIJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBIJ_ECOLI pepwindow swissprot:YBIJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBIJ_ECOLI sigcleave swissprot:YBIJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBIJ_ECOLI ## Database ID URL or Descriptions # AltName ZINT_ECOLI Cadmium-induced protein ZinT # BioGrid 4260387 36 # DISRUPTION PHENOTYPE ZINT_ECOLI Mutant shows a growth defect and a lowered cellular Zn(2+) level under Zn(2+) limitation. Mutant does not bind cadmium. {ECO 0000269|PubMed 17632755, ECO 0000269|PubMed 17931600, ECO 0000269|PubMed 19377097}. # EcoGene EG14049 zinT # FUNCTION ZINT_ECOLI May function as a periplasmic zinc chaperone or mediate direct transport of zinc from the periplasm to the cytoplasm under zinc-limited conditions. Binds zinc with high affinity, and can also bind cadmium, mercury or nickel. Preferentially binds Zn(2+) over Cd(2+). Contains one high affinity metal binding site, and can bind additional metal ions at other sites. {ECO 0000269|PubMed 17931600, ECO 0000269|PubMed 19377097}. # GO_component GO:0005737 cytoplasm; IDA:EcoCyc. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_function GO:0046870 cadmium ion binding; IDA:EcoCyc. # GO_process GO:0034224 cellular response to zinc ion starvation; IEP:EcoCyc. # GO_process GO:0046686 response to cadmium ion; IEP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # Gene3D 2.40.128.20 -; 1. # INDUCTION ZINT_ECOLI Repressed by Zur. Up-regulated in response to extreme Zn(2+) deprivation. Also induced by cadmium and hydrogen peroxide. {ECO 0000269|PubMed 12480884, ECO 0000269|PubMed 19377097, ECO 0000269|PubMed 22196016}. # IntAct P76344 15 # InterPro IPR011038 Calycin-like # InterPro IPR012674 Calycin # InterPro IPR015304 ZinT_dom # Organism ZINT_ECOLI Escherichia coli (strain K12) # PATRIC 32119277 VBIEscCol129921_2053 # PDB 1OEE X-ray; 2.10 A; A=24-216 # PDB 1OEJ X-ray; 1.81 A; A=24-216 # PDB 1OEK X-ray; 2.40 A; A=24-216 # PDB 1S7D X-ray; 2.17 A; A=1-216 # PDB 1TXL X-ray; 1.70 A; A=2-216 # PDB 5AQ6 X-ray; 1.79 A; A=24-216 # PIR A64962 A64962 # Pfam PF09223 ZinT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ZINT_ECOLI Metal-binding protein ZinT # RefSeq NP_416482 NC_000913.3 # RefSeq WP_001007805 NZ_LN832404.1 # SIMILARITY Belongs to the calycin superfamily. ZinT family. {ECO 0000305}. # SUBCELLULAR LOCATION ZINT_ECOLI Cytoplasm {ECO 0000269|PubMed 12480884}. Periplasm {ECO 0000269|PubMed 12480884}. Note=Cytoplasmic in nonstressed cells, and exported to the periplasm upon exposure to cadmium. # SUPFAM SSF50814 SSF50814 # eggNOG COG3443 LUCA # eggNOG ENOG4108MEK Bacteria BLAST swissprot:ZINT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ZINT_ECOLI BioCyc ECOL316407:JW1956-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1956-MONOMER BioCyc EcoCyc:G7061-MONOMER http://biocyc.org/getid?id=EcoCyc:G7061-MONOMER DOI 10.1007/s00284-006-0516-5 http://dx.doi.org/10.1007/s00284-006-0516-5 DOI 10.1016/j.bbrc.2007.09.094 http://dx.doi.org/10.1016/j.bbrc.2007.09.094 DOI 10.1016/j.jinorgbio.2011.11.022 http://dx.doi.org/10.1016/j.jinorgbio.2011.11.022 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M109.001503 http://dx.doi.org/10.1074/jbc.M109.001503 DOI 10.1074/jbc.M304484200 http://dx.doi.org/10.1074/jbc.M304484200 DOI 10.1099/00221287-144-4-1045 http://dx.doi.org/10.1099/00221287-144-4-1045 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3802 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3802 EcoGene EG14049 http://www.ecogene.org/geneInfo.php?eg_id=EG14049 EnsemblBacteria AAC75039 http://www.ensemblgenomes.org/id/AAC75039 EnsemblBacteria AAC75039 http://www.ensemblgenomes.org/id/AAC75039 EnsemblBacteria BAE76561 http://www.ensemblgenomes.org/id/BAE76561 EnsemblBacteria BAE76561 http://www.ensemblgenomes.org/id/BAE76561 EnsemblBacteria BAE76561 http://www.ensemblgenomes.org/id/BAE76561 EnsemblBacteria b1973 http://www.ensemblgenomes.org/id/b1973 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0046870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046870 GO_process GO:0034224 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034224 GO_process GO:0046686 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046686 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 2.40.128.20 http://www.cathdb.info/version/latest/superfamily/2.40.128.20 GeneID 946480 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946480 HOGENOM HOG000219533 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219533&db=HOGENOM6 InParanoid P76344 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76344 IntAct P76344 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76344* InterPro IPR011038 http://www.ebi.ac.uk/interpro/entry/IPR011038 InterPro IPR012674 http://www.ebi.ac.uk/interpro/entry/IPR012674 InterPro IPR015304 http://www.ebi.ac.uk/interpro/entry/IPR015304 KEGG_Gene ecj:JW1956 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1956 KEGG_Gene eco:b1973 http://www.genome.jp/dbget-bin/www_bget?eco:b1973 OMA VQFSDHT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VQFSDHT PDB 1OEE http://www.ebi.ac.uk/pdbe-srv/view/entry/1OEE PDB 1OEJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1OEJ PDB 1OEK http://www.ebi.ac.uk/pdbe-srv/view/entry/1OEK PDB 1S7D http://www.ebi.ac.uk/pdbe-srv/view/entry/1S7D PDB 1TXL http://www.ebi.ac.uk/pdbe-srv/view/entry/1TXL PDB 5AQ6 http://www.ebi.ac.uk/pdbe-srv/view/entry/5AQ6 PDBsum 1OEE http://www.ebi.ac.uk/pdbsum/1OEE PDBsum 1OEJ http://www.ebi.ac.uk/pdbsum/1OEJ PDBsum 1OEK http://www.ebi.ac.uk/pdbsum/1OEK PDBsum 1S7D http://www.ebi.ac.uk/pdbsum/1S7D PDBsum 1TXL http://www.ebi.ac.uk/pdbsum/1TXL PDBsum 5AQ6 http://www.ebi.ac.uk/pdbsum/5AQ6 PSORT swissprot:ZINT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ZINT_ECOLI PSORT-B swissprot:ZINT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ZINT_ECOLI PSORT2 swissprot:ZINT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ZINT_ECOLI Pfam PF09223 http://pfam.xfam.org/family/PF09223 Phobius swissprot:ZINT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ZINT_ECOLI PhylomeDB P76344 http://phylomedb.org/?seqid=P76344 ProteinModelPortal P76344 http://www.proteinmodelportal.org/query/uniprot/P76344 PubMed 12480884 http://www.ncbi.nlm.nih.gov/pubmed/12480884 PubMed 12909634 http://www.ncbi.nlm.nih.gov/pubmed/12909634 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17632755 http://www.ncbi.nlm.nih.gov/pubmed/17632755 PubMed 17931600 http://www.ncbi.nlm.nih.gov/pubmed/17931600 PubMed 19377097 http://www.ncbi.nlm.nih.gov/pubmed/19377097 PubMed 22196016 http://www.ncbi.nlm.nih.gov/pubmed/22196016 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9579078 http://www.ncbi.nlm.nih.gov/pubmed/9579078 RefSeq NP_416482 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416482 RefSeq WP_001007805 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001007805 SMR P76344 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76344 STRING 511145.b1973 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1973&targetmode=cogs SUPFAM SSF50814 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50814 SWISS-2DPAGE P76344 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P76344 UniProtKB ZINT_ECOLI http://www.uniprot.org/uniprot/ZINT_ECOLI UniProtKB-AC P76344 http://www.uniprot.org/uniprot/P76344 charge swissprot:ZINT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ZINT_ECOLI eggNOG COG3443 http://eggnogapi.embl.de/nog_data/html/tree/COG3443 eggNOG ENOG4108MEK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MEK epestfind swissprot:ZINT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ZINT_ECOLI garnier swissprot:ZINT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ZINT_ECOLI helixturnhelix swissprot:ZINT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ZINT_ECOLI hmoment swissprot:ZINT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ZINT_ECOLI iep swissprot:ZINT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ZINT_ECOLI inforesidue swissprot:ZINT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ZINT_ECOLI octanol swissprot:ZINT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ZINT_ECOLI pepcoil swissprot:ZINT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ZINT_ECOLI pepdigest swissprot:ZINT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ZINT_ECOLI pepinfo swissprot:ZINT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ZINT_ECOLI pepnet swissprot:ZINT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ZINT_ECOLI pepstats swissprot:ZINT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ZINT_ECOLI pepwheel swissprot:ZINT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ZINT_ECOLI pepwindow swissprot:ZINT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ZINT_ECOLI sigcleave swissprot:ZINT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ZINT_ECOLI ## Database ID URL or Descriptions # AltName RIMI_ECOLI Acetylating enzyme for N-terminal of ribosomal protein S18 # BioGrid 4262786 3 # CATALYTIC ACTIVITY RIMI_ECOLI Acetyl-CoA + ribosomal-protein L-alanine = CoA + ribosomal-protein N-acetyl-L-alanine. # EcoGene EG10850 rimI # FUNCTION RIMI_ECOLI This enzyme acetylates the N-terminal alanine of ribosomal protein S18. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_component GO:0031248 protein acetyltransferase complex; IBA:GO_Central. # GO_function GO:0008080 N-acetyltransferase activity; IMP:EcoliWiki. # GO_function GO:0008999 ribosomal-protein-alanine N-acetyltransferase activity; IMP:EcoliWiki. # GO_process GO:0006464 cellular protein modification process; IMP:EcoliWiki. # GO_process GO:0006474 N-terminal protein amino acid acetylation; IMP:EcoliWiki. # GO_process GO:0017189 N-terminal peptidyl-alanine acetylation; IMP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0006464 cellular protein modification process # Gene3D 3.40.630.30 -; 1. # InterPro IPR000182 GNAT_dom # InterPro IPR006464 Rbsml_AcTrfase # InterPro IPR016181 Acyl_CoA_acyltransferase # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # Organism RIMI_ECOLI Escherichia coli (strain K12) # PATRIC 32124356 VBIEscCol129921_4518 # PDB 5ISV X-ray; 1.35 A; A/B=1-148 # PIR D65252 D65252 # PROSITE PS51186 GNAT # Pfam PF00583 Acetyltransf_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RIMI_ECOLI Ribosomal-protein-alanine acetyltransferase # RefSeq NP_418790 NC_000913.3 # RefSeq WP_001092461 NZ_LN832404.1 # SIMILARITY Belongs to the acetyltransferase family. RimI subfamily. {ECO 0000305}. # SIMILARITY Contains 1 N-acetyltransferase domain. {ECO:0000255|PROSITE-ProRule PRU00532}. # SUBCELLULAR LOCATION RIMI_ECOLI Cytoplasm. # SUPFAM SSF55729 SSF55729 # TIGRFAMs TIGR01575 rimI # eggNOG COG0456 LUCA # eggNOG ENOG4105KEG Bacteria BLAST swissprot:RIMI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RIMI_ECOLI BioCyc ECOL316407:JW4335-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4335-MONOMER BioCyc EcoCyc:EG10850-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10850-MONOMER BioCyc MetaCyc:EG10850-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10850-MONOMER COG COG0456 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0456 DIP DIP-48259N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48259N DOI 10.1007/BF00331153 http://dx.doi.org/10.1007/BF00331153 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.128 http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.128 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L05387 http://www.ebi.ac.uk/ena/data/view/L05387 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X06117 http://www.ebi.ac.uk/ena/data/view/X06117 ENZYME 2.3.1.128 http://enzyme.expasy.org/EC/2.3.1.128 EchoBASE EB0843 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0843 EcoGene EG10850 http://www.ecogene.org/geneInfo.php?eg_id=EG10850 EnsemblBacteria AAC77326 http://www.ensemblgenomes.org/id/AAC77326 EnsemblBacteria AAC77326 http://www.ensemblgenomes.org/id/AAC77326 EnsemblBacteria BAE78361 http://www.ensemblgenomes.org/id/BAE78361 EnsemblBacteria BAE78361 http://www.ensemblgenomes.org/id/BAE78361 EnsemblBacteria BAE78361 http://www.ensemblgenomes.org/id/BAE78361 EnsemblBacteria b4373 http://www.ensemblgenomes.org/id/b4373 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0031248 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031248 GO_function GO:0008080 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008080 GO_function GO:0008999 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008999 GO_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GO_process GO:0006474 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006474 GO_process GO:0017189 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017189 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 Gene3D 3.40.630.30 http://www.cathdb.info/version/latest/superfamily/3.40.630.30 GeneID 948894 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948894 HOGENOM HOG000078523 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000078523&db=HOGENOM6 InParanoid P0A944 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A944 IntAct P0A944 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A944* IntEnz 2.3.1.128 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.128 InterPro IPR000182 http://www.ebi.ac.uk/interpro/entry/IPR000182 InterPro IPR006464 http://www.ebi.ac.uk/interpro/entry/IPR006464 InterPro IPR016181 http://www.ebi.ac.uk/interpro/entry/IPR016181 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW4335 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4335 KEGG_Gene eco:b4373 http://www.genome.jp/dbget-bin/www_bget?eco:b4373 KEGG_Orthology KO:K03789 http://www.genome.jp/dbget-bin/www_bget?KO:K03789 OMA NICVHPD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NICVHPD PDB 5ISV http://www.ebi.ac.uk/pdbe-srv/view/entry/5ISV PDBsum 5ISV http://www.ebi.ac.uk/pdbsum/5ISV PROSITE PS51186 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51186 PSORT swissprot:RIMI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RIMI_ECOLI PSORT-B swissprot:RIMI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RIMI_ECOLI PSORT2 swissprot:RIMI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RIMI_ECOLI Pfam PF00583 http://pfam.xfam.org/family/PF00583 Phobius swissprot:RIMI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RIMI_ECOLI PhylomeDB P0A944 http://phylomedb.org/?seqid=P0A944 ProteinModelPortal P0A944 http://www.proteinmodelportal.org/query/uniprot/P0A944 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2828880 http://www.ncbi.nlm.nih.gov/pubmed/2828880 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8366044 http://www.ncbi.nlm.nih.gov/pubmed/8366044 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418790 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418790 RefSeq WP_001092461 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001092461 SMR P0A944 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A944 STRING 511145.b4373 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4373&targetmode=cogs STRING COG0456 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0456&targetmode=cogs SUPFAM SSF55729 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55729 TIGRFAMs TIGR01575 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01575 UniProtKB RIMI_ECOLI http://www.uniprot.org/uniprot/RIMI_ECOLI UniProtKB-AC P0A944 http://www.uniprot.org/uniprot/P0A944 charge swissprot:RIMI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RIMI_ECOLI eggNOG COG0456 http://eggnogapi.embl.de/nog_data/html/tree/COG0456 eggNOG ENOG4105KEG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KEG epestfind swissprot:RIMI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RIMI_ECOLI garnier swissprot:RIMI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RIMI_ECOLI helixturnhelix swissprot:RIMI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RIMI_ECOLI hmoment swissprot:RIMI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RIMI_ECOLI iep swissprot:RIMI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RIMI_ECOLI inforesidue swissprot:RIMI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RIMI_ECOLI octanol swissprot:RIMI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RIMI_ECOLI pepcoil swissprot:RIMI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RIMI_ECOLI pepdigest swissprot:RIMI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RIMI_ECOLI pepinfo swissprot:RIMI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RIMI_ECOLI pepnet swissprot:RIMI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RIMI_ECOLI pepstats swissprot:RIMI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RIMI_ECOLI pepwheel swissprot:RIMI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RIMI_ECOLI pepwindow swissprot:RIMI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RIMI_ECOLI sigcleave swissprot:RIMI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RIMI_ECOLI ## Database ID URL or Descriptions # BioGrid 4262898 284 # DOMAIN BAMC_ECOLI Contains two well-defined domains connected by a flexible linker. The C-terminal domain may serve as an important protein- binding surface for interaction with other Bam components or substrates. In addition, contains a long unstructured N-terminal region, which is required to stabilize the BamCD complex. {ECO 0000269|PubMed 21624375, ECO 0000269|PubMed 21937441, ECO 0000269|PubMed 22102230}. # EcoGene EG10658 bamC # FUNCTION BAMC_ECOLI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Nonessential member of the complex that stabilizes the interaction between the essential proteins BamA and BamD. {ECO 0000255|HAMAP-Rule MF_00924, ECO 0000269|PubMed 20378773, ECO 0000269|PubMed 21823654, ECO 0000269|PubMed 22178970}. # GO_component GO:0009986 cell surface; IDA:EcoCyc. # GO_component GO:1990063 Bam protein complex; IDA:EcoCyc. # GO_process GO:0043165 Gram-negative-bacterium-type cell outer membrane assembly; IGI:EcoliWiki. # GO_process GO:0051205 protein insertion into membrane; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043234 protein complex # GOslim_process GO:0008150 biological_process # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0061024 membrane organization # HAMAP MF_00924 OM_assembly_BamC # INTERACTION BAMC_ECOLI Self; NbExp=2; IntAct=EBI-1129043, EBI-1129043; P0AC02 bamD; NbExp=4; IntAct=EBI-1129043, EBI-1128087; # IntAct P0A903 7 # InterPro IPR010653 NlpB/DapX # InterPro IPR014524 BamC # Organism BAMC_ECOLI Escherichia coli (strain K12) # PATRIC 32120341 VBIEscCol129921_2573 # PDB 2LAE NMR; -; A=101-344 # PDB 2LAF NMR; -; A=101-344 # PDB 2YH5 X-ray; 1.25 A; A=226-344 # PDB 2YH6 X-ray; 1.55 A; A/B/C/D=101-212 # PDB 3SNS X-ray; 1.50 A; A=224-343 # PDB 3TGO X-ray; 2.90 A; C/D=26-344 # PDB 5AYW X-ray; 3.56 A; C=33-88 # PDB 5D0O X-ray; 2.90 A; C=1-344 # PDB 5D0Q X-ray; 3.50 A; C/G=1-344 # PDB 5EKQ X-ray; 3.39 A; C=25-344 # PDB 5LJO EM; 4.90 A; C=25-189 # PIR D65023 D65023 # PIRSF PIRSF026343 NlpB # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF06804 Lipoprotein_18 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Outer membrane protein assembly factor BamC {ECO:0000255|HAMAP-Rule MF_00924} # RefSeq NP_416972 NC_000913.3 # RefSeq WP_001297320 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=M33928; Type=Frameshift; Positions=50, 64, 81, 134; Evidence={ECO 0000305}; # SIMILARITY Belongs to the BamC family. {ECO:0000255|HAMAP- Rule MF_00924}. # SUBCELLULAR LOCATION BAMC_ECOLI Cell outer membrane {ECO 0000255|HAMAP- Rule MF_00924, ECO 0000269|PubMed 16079137}; Lipid-anchor {ECO 0000255|HAMAP-Rule MF_00924, ECO 0000269|PubMed 16079137}. # SUBUNIT BAMC_ECOLI Part of the Bam complex, which is composed of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE. Forms a subcomplex with BamD and BamE. {ECO 0000255|HAMAP- Rule MF_00924, ECO 0000269|PubMed 15851030, ECO 0000269|PubMed 16079137, ECO 0000269|PubMed 16824102, ECO 0000269|PubMed 20378773, ECO 0000269|PubMed 21823654}. # TCDB 1.B.33.1 the outer membrane protein insertion porin (bam complex) (ompip) family # eggNOG COG3317 LUCA # eggNOG ENOG4107EG0 Bacteria BLAST swissprot:BAMC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BAMC_ECOLI BioCyc ECOL316407:JW2462-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2462-MONOMER BioCyc EcoCyc:EG10658-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10658-MONOMER COG COG3317 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3317 DIP DIP-39898N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-39898N DOI 10.1007/s12104-009-9175-3 http://dx.doi.org/10.1007/s12104-009-9175-3 DOI 10.1016/j.cell.2005.02.015 http://dx.doi.org/10.1016/j.cell.2005.02.015 DOI 10.1016/j.jmb.2011.05.022 http://dx.doi.org/10.1016/j.jmb.2011.05.022 DOI 10.1021/bi2010784 http://dx.doi.org/10.1021/bi2010784 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M111.238931 http://dx.doi.org/10.1074/jbc.M111.238931 DOI 10.1074/jbc.M111.298166 http://dx.doi.org/10.1074/jbc.M111.298166 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1107/S1744309110034160 http://dx.doi.org/10.1107/S1744309110034160 DOI 10.1107/S174430911103363X http://dx.doi.org/10.1107/S174430911103363X DOI 10.1111/j.1365-2958.2006.05211.x http://dx.doi.org/10.1111/j.1365-2958.2006.05211.x DOI 10.1126/science.1188919 http://dx.doi.org/10.1126/science.1188919 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.06426-11 http://dx.doi.org/10.1128/JB.06426-11 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M33928 http://www.ebi.ac.uk/ena/data/view/M33928 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X57402 http://www.ebi.ac.uk/ena/data/view/X57402 EchoBASE EB0652 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0652 EcoGene EG10658 http://www.ecogene.org/geneInfo.php?eg_id=EG10658 EnsemblBacteria AAC75530 http://www.ensemblgenomes.org/id/AAC75530 EnsemblBacteria AAC75530 http://www.ensemblgenomes.org/id/AAC75530 EnsemblBacteria BAA16354 http://www.ensemblgenomes.org/id/BAA16354 EnsemblBacteria BAA16354 http://www.ensemblgenomes.org/id/BAA16354 EnsemblBacteria BAA16354 http://www.ensemblgenomes.org/id/BAA16354 EnsemblBacteria b2477 http://www.ensemblgenomes.org/id/b2477 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009986 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986 GO_component GO:1990063 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990063 GO_process GO:0043165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043165 GO_process GO:0051205 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051205 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0061024 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024 GeneID 946954 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946954 HAMAP MF_00924 http://hamap.expasy.org/unirule/MF_00924 HOGENOM HOG000123040 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000123040&db=HOGENOM6 IntAct P0A903 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A903* InterPro IPR010653 http://www.ebi.ac.uk/interpro/entry/IPR010653 InterPro IPR014524 http://www.ebi.ac.uk/interpro/entry/IPR014524 KEGG_Gene ecj:JW2462 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2462 KEGG_Gene eco:b2477 http://www.genome.jp/dbget-bin/www_bget?eco:b2477 KEGG_Orthology KO:K07287 http://www.genome.jp/dbget-bin/www_bget?KO:K07287 OMA QKSMVAK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QKSMVAK PDB 2LAE http://www.ebi.ac.uk/pdbe-srv/view/entry/2LAE PDB 2LAF http://www.ebi.ac.uk/pdbe-srv/view/entry/2LAF PDB 2YH5 http://www.ebi.ac.uk/pdbe-srv/view/entry/2YH5 PDB 2YH6 http://www.ebi.ac.uk/pdbe-srv/view/entry/2YH6 PDB 3SNS http://www.ebi.ac.uk/pdbe-srv/view/entry/3SNS PDB 3TGO http://www.ebi.ac.uk/pdbe-srv/view/entry/3TGO PDB 5AYW http://www.ebi.ac.uk/pdbe-srv/view/entry/5AYW PDB 5D0O http://www.ebi.ac.uk/pdbe-srv/view/entry/5D0O PDB 5D0Q http://www.ebi.ac.uk/pdbe-srv/view/entry/5D0Q PDB 5EKQ http://www.ebi.ac.uk/pdbe-srv/view/entry/5EKQ PDB 5LJO http://www.ebi.ac.uk/pdbe-srv/view/entry/5LJO PDBsum 2LAE http://www.ebi.ac.uk/pdbsum/2LAE PDBsum 2LAF http://www.ebi.ac.uk/pdbsum/2LAF PDBsum 2YH5 http://www.ebi.ac.uk/pdbsum/2YH5 PDBsum 2YH6 http://www.ebi.ac.uk/pdbsum/2YH6 PDBsum 3SNS http://www.ebi.ac.uk/pdbsum/3SNS PDBsum 3TGO http://www.ebi.ac.uk/pdbsum/3TGO PDBsum 5AYW http://www.ebi.ac.uk/pdbsum/5AYW PDBsum 5D0O http://www.ebi.ac.uk/pdbsum/5D0O PDBsum 5D0Q http://www.ebi.ac.uk/pdbsum/5D0Q PDBsum 5EKQ http://www.ebi.ac.uk/pdbsum/5EKQ PDBsum 5LJO http://www.ebi.ac.uk/pdbsum/5LJO PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:BAMC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BAMC_ECOLI PSORT-B swissprot:BAMC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BAMC_ECOLI PSORT2 swissprot:BAMC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BAMC_ECOLI Pfam PF06804 http://pfam.xfam.org/family/PF06804 Phobius swissprot:BAMC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BAMC_ECOLI ProteinModelPortal P0A903 http://www.proteinmodelportal.org/query/uniprot/P0A903 PubMed 15851030 http://www.ncbi.nlm.nih.gov/pubmed/15851030 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16824102 http://www.ncbi.nlm.nih.gov/pubmed/16824102 PubMed 1885529 http://www.ncbi.nlm.nih.gov/pubmed/1885529 PubMed 19888691 http://www.ncbi.nlm.nih.gov/pubmed/19888691 PubMed 20378773 http://www.ncbi.nlm.nih.gov/pubmed/20378773 PubMed 21139201 http://www.ncbi.nlm.nih.gov/pubmed/21139201 PubMed 2120198 http://www.ncbi.nlm.nih.gov/pubmed/2120198 PubMed 21586578 http://www.ncbi.nlm.nih.gov/pubmed/21586578 PubMed 21624375 http://www.ncbi.nlm.nih.gov/pubmed/21624375 PubMed 21823654 http://www.ncbi.nlm.nih.gov/pubmed/21823654 PubMed 21937441 http://www.ncbi.nlm.nih.gov/pubmed/21937441 PubMed 22102230 http://www.ncbi.nlm.nih.gov/pubmed/22102230 PubMed 22178970 http://www.ncbi.nlm.nih.gov/pubmed/22178970 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416972 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416972 RefSeq WP_001297320 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001297320 SMR P0A903 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A903 STRING 511145.b2477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2477&targetmode=cogs STRING COG3317 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3317&targetmode=cogs SWISS-2DPAGE P0A903 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A903 TCDB 1.B.33.1 http://www.tcdb.org/search/result.php?tc=1.B.33.1 UniProtKB BAMC_ECOLI http://www.uniprot.org/uniprot/BAMC_ECOLI UniProtKB-AC P0A903 http://www.uniprot.org/uniprot/P0A903 charge swissprot:BAMC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BAMC_ECOLI eggNOG COG3317 http://eggnogapi.embl.de/nog_data/html/tree/COG3317 eggNOG ENOG4107EG0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107EG0 epestfind swissprot:BAMC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BAMC_ECOLI garnier swissprot:BAMC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BAMC_ECOLI helixturnhelix swissprot:BAMC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BAMC_ECOLI hmoment swissprot:BAMC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BAMC_ECOLI iep swissprot:BAMC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BAMC_ECOLI inforesidue swissprot:BAMC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BAMC_ECOLI octanol swissprot:BAMC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BAMC_ECOLI pepcoil swissprot:BAMC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BAMC_ECOLI pepdigest swissprot:BAMC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BAMC_ECOLI pepinfo swissprot:BAMC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BAMC_ECOLI pepnet swissprot:BAMC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BAMC_ECOLI pepstats swissprot:BAMC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BAMC_ECOLI pepwheel swissprot:BAMC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BAMC_ECOLI pepwindow swissprot:BAMC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BAMC_ECOLI sigcleave swissprot:BAMC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BAMC_ECOLI ## Database ID URL or Descriptions # BioGrid 4263132 6 # EcoGene EG11625 artI # FUNCTION ARTI_ECOLI Part of the ABC transporter complex ArtPIQMJ involved in arginine transport. {ECO 0000269|PubMed 8801422}. # GO_component GO:0016020 membrane; IEA:InterPro. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_component GO:0042597 periplasmic space; IDA:EcoliWiki. # GO_function GO:0004970 ionotropic glutamate receptor activity; IEA:InterPro. # GO_process GO:0006865 amino acid transport; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # IntAct P30859 3 # InterPro IPR001320 Iontro_rcpt # InterPro IPR001638 Solute-binding_3/MltF_N # InterPro IPR005768 Lys_Arg_Orn-bd # InterPro IPR018313 SBP_3_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00229 Arginine transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism ARTI_ECOLI Escherichia coli (strain K12) # PATRIC 32116933 VBIEscCol129921_0892 # PIR G64824 G64824 # PROSITE PS01039 SBP_BACTERIAL_3 # Pfam PF00497 SBP_bac_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ARTI_ECOLI Putative ABC transporter arginine-binding protein 2 # RefSeq NP_415384 NC_000913.3 # RefSeq WP_000756569 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial solute-binding protein 3 family. {ECO 0000305}. # SMART SM00062 PBPb # SMART SM00079 PBPe # SUBCELLULAR LOCATION ARTI_ECOLI Periplasm {ECO 0000269|PubMed 8801422}. # SUBUNIT The complex is composed of two ATP-binding proteins (ArtP), two transmembrane proteins (ArtM and ArtQ) and two solute- binding proteins (ArtJ and ArtI). {ECO:0000305|PubMed 8801422}. # TCDB 3.A.1.3 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR01096 3A0103s03R # eggNOG COG0834 LUCA # eggNOG ENOG4106PMH Bacteria BLAST swissprot:ARTI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARTI_ECOLI BioCyc ECOL316407:JW0847-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0847-MONOMER BioCyc EcoCyc:ARTI-MONOMER http://biocyc.org/getid?id=EcoCyc:ARTI-MONOMER COG COG0834 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0834 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1998.1726 http://dx.doi.org/10.1006/jmbi.1998.1726 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1995.mmi_17040675.x http://dx.doi.org/10.1111/j.1365-2958.1995.mmi_17040675.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X86160 http://www.ebi.ac.uk/ena/data/view/X86160 EchoBASE EB1582 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1582 EcoGene EG11625 http://www.ecogene.org/geneInfo.php?eg_id=EG11625 EnsemblBacteria AAC73950 http://www.ensemblgenomes.org/id/AAC73950 EnsemblBacteria AAC73950 http://www.ensemblgenomes.org/id/AAC73950 EnsemblBacteria BAA35577 http://www.ensemblgenomes.org/id/BAA35577 EnsemblBacteria BAA35577 http://www.ensemblgenomes.org/id/BAA35577 EnsemblBacteria BAA35577 http://www.ensemblgenomes.org/id/BAA35577 EnsemblBacteria b0863 http://www.ensemblgenomes.org/id/b0863 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0004970 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004970 GO_process GO:0006865 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948988 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948988 HOGENOM HOG000031896 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000031896&db=HOGENOM6 InParanoid P30859 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30859 IntAct P30859 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P30859* InterPro IPR001320 http://www.ebi.ac.uk/interpro/entry/IPR001320 InterPro IPR001638 http://www.ebi.ac.uk/interpro/entry/IPR001638 InterPro IPR005768 http://www.ebi.ac.uk/interpro/entry/IPR005768 InterPro IPR018313 http://www.ebi.ac.uk/interpro/entry/IPR018313 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0847 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0847 KEGG_Gene eco:b0863 http://www.genome.jp/dbget-bin/www_bget?eco:b0863 KEGG_Orthology KO:K09997 http://www.genome.jp/dbget-bin/www_bget?KO:K09997 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA TYETIYK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TYETIYK PROSITE PS01039 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01039 PSORT swissprot:ARTI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARTI_ECOLI PSORT-B swissprot:ARTI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARTI_ECOLI PSORT2 swissprot:ARTI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARTI_ECOLI Pfam PF00497 http://pfam.xfam.org/family/PF00497 Phobius swissprot:ARTI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARTI_ECOLI PhylomeDB P30859 http://phylomedb.org/?seqid=P30859 ProteinModelPortal P30859 http://www.proteinmodelportal.org/query/uniprot/P30859 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8501075 http://www.ncbi.nlm.nih.gov/pubmed/8501075 PubMed 8801422 http://www.ncbi.nlm.nih.gov/pubmed/8801422 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 RefSeq NP_415384 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415384 RefSeq WP_000756569 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000756569 SMART SM00062 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00062 SMART SM00079 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00079 SMR P30859 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P30859 STRING 511145.b0863 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0863&targetmode=cogs STRING COG0834 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0834&targetmode=cogs SWISS-2DPAGE P30859 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P30859 TCDB 3.A.1.3 http://www.tcdb.org/search/result.php?tc=3.A.1.3 TIGRFAMs TIGR01096 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01096 UniProtKB ARTI_ECOLI http://www.uniprot.org/uniprot/ARTI_ECOLI UniProtKB-AC P30859 http://www.uniprot.org/uniprot/P30859 charge swissprot:ARTI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARTI_ECOLI eggNOG COG0834 http://eggnogapi.embl.de/nog_data/html/tree/COG0834 eggNOG ENOG4106PMH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106PMH epestfind swissprot:ARTI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARTI_ECOLI garnier swissprot:ARTI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARTI_ECOLI helixturnhelix swissprot:ARTI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARTI_ECOLI hmoment swissprot:ARTI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARTI_ECOLI iep swissprot:ARTI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARTI_ECOLI inforesidue swissprot:ARTI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARTI_ECOLI octanol swissprot:ARTI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARTI_ECOLI pepcoil swissprot:ARTI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARTI_ECOLI pepdigest swissprot:ARTI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARTI_ECOLI pepinfo swissprot:ARTI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARTI_ECOLI pepnet swissprot:ARTI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARTI_ECOLI pepstats swissprot:ARTI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARTI_ECOLI pepwheel swissprot:ARTI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARTI_ECOLI pepwindow swissprot:ARTI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARTI_ECOLI sigcleave swissprot:ARTI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARTI_ECOLI ## Database ID URL or Descriptions # AltName MEPH_ECOLI Murein hydrolase MepH # BioGrid 4259398 202 # DISRUPTION PHENOTYPE A triple mepS-mepH-mepM mutant is inviable, whereas a double mepS-mepM will grow on a nutrient-poor medium but not on a rich medium, suggesting the 3 endopeptidases are functionally redundant in vivo. Depletion experiments of the double or triple mutants lead to cell lysis, as well as significantly decreased incorporation of mDAP into peptidogylcan sacculi and increased amounts of the enzyme's substrate (Tetra- Tetra-anhydro muropeptide). {ECO:0000269|PubMed 23062283}. # EcoGene EG13949 mepH # FUNCTION MEPH_ECOLI A murein DD-endopeptidase with specificity for D-Ala- meso-diaminopimelic acid (mDAP) cross-links. Its role is probably to cleave D-Ala-mDAP cross-links to allow insertion of new glycans and thus cell wall expansion. Functionally redundant with MepM and MepH. Partially suppresses an mepS disruption mutant. {ECO 0000269|PubMed 23062283}. # GO_function GO:0004175 endopeptidase activity; IDA:CACAO. # GO_function GO:0008234 cysteine-type peptidase activity; IEA:UniProtKB-KW. # GO_process GO:0000270 peptidoglycan metabolic process; IDA:EcoCyc. # GO_process GO:0009254 peptidoglycan turnover; IMP:CACAO. # GO_process GO:0045227 capsule polysaccharide biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_function GO:0008233 peptidase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 3.90.1720.10 -; 1. # InterPro IPR000064 NLP_P60_dom # Organism MEPH_ECOLI Escherichia coli (strain K12) # PATHWAY MEPH_ECOLI Cell wall biogenesis; cell wall polysaccharide biosynthesis. # PATRIC 32118614 VBIEscCol129921_1727 # PIR A64923 A64923 # Pfam PF00877 NLPC_P60 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MEPH_ECOLI Murein DD-endopeptidase MepH # RefSeq NP_416172 NC_000913.3 # RefSeq WP_000101193 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase C40 family. {ECO 0000305}. # eggNOG COG0791 LUCA # eggNOG ENOG4105K4H Bacteria BLAST swissprot:MEPH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MEPH_ECOLI BioCyc ECOL316407:JW5270-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5270-MONOMER BioCyc EcoCyc:G6892-MONOMER http://biocyc.org/getid?id=EcoCyc:G6892-MONOMER BioCyc MetaCyc:G6892-MONOMER http://biocyc.org/getid?id=MetaCyc:G6892-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1111/mmi.12058 http://dx.doi.org/10.1111/mmi.12058 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.4.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.4.-.- http://enzyme.expasy.org/EC/3.4.-.- EchoBASE EB3707 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3707 EcoGene EG13949 http://www.ecogene.org/geneInfo.php?eg_id=EG13949 EnsemblBacteria AAC74727 http://www.ensemblgenomes.org/id/AAC74727 EnsemblBacteria AAC74727 http://www.ensemblgenomes.org/id/AAC74727 EnsemblBacteria BAA15421 http://www.ensemblgenomes.org/id/BAA15421 EnsemblBacteria BAA15421 http://www.ensemblgenomes.org/id/BAA15421 EnsemblBacteria BAA15421 http://www.ensemblgenomes.org/id/BAA15421 EnsemblBacteria b1655 http://www.ensemblgenomes.org/id/b1655 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004175 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004175 GO_function GO:0008234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008234 GO_process GO:0000270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000270 GO_process GO:0009254 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009254 GO_process GO:0045227 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045227 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 3.90.1720.10 http://www.cathdb.info/version/latest/superfamily/3.90.1720.10 GeneID 945210 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945210 HOGENOM HOG000229979 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000229979&db=HOGENOM6 InParanoid P76190 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76190 IntEnz 3.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4 InterPro IPR000064 http://www.ebi.ac.uk/interpro/entry/IPR000064 KEGG_Gene ecj:JW5270 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5270 KEGG_Gene eco:b1655 http://www.genome.jp/dbget-bin/www_bget?eco:b1655 OMA TEKCTPR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TEKCTPR PSORT swissprot:MEPH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MEPH_ECOLI PSORT-B swissprot:MEPH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MEPH_ECOLI PSORT2 swissprot:MEPH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MEPH_ECOLI Pfam PF00877 http://pfam.xfam.org/family/PF00877 Phobius swissprot:MEPH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MEPH_ECOLI PhylomeDB P76190 http://phylomedb.org/?seqid=P76190 ProteinModelPortal P76190 http://www.proteinmodelportal.org/query/uniprot/P76190 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 23062283 http://www.ncbi.nlm.nih.gov/pubmed/23062283 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416172 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416172 RefSeq WP_000101193 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000101193 STRING 511145.b1655 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1655&targetmode=cogs UniProtKB MEPH_ECOLI http://www.uniprot.org/uniprot/MEPH_ECOLI UniProtKB-AC P76190 http://www.uniprot.org/uniprot/P76190 charge swissprot:MEPH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MEPH_ECOLI eggNOG COG0791 http://eggnogapi.embl.de/nog_data/html/tree/COG0791 eggNOG ENOG4105K4H http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K4H epestfind swissprot:MEPH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MEPH_ECOLI garnier swissprot:MEPH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MEPH_ECOLI helixturnhelix swissprot:MEPH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MEPH_ECOLI hmoment swissprot:MEPH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MEPH_ECOLI iep swissprot:MEPH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MEPH_ECOLI inforesidue swissprot:MEPH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MEPH_ECOLI octanol swissprot:MEPH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MEPH_ECOLI pepcoil swissprot:MEPH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MEPH_ECOLI pepdigest swissprot:MEPH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MEPH_ECOLI pepinfo swissprot:MEPH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MEPH_ECOLI pepnet swissprot:MEPH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MEPH_ECOLI pepstats swissprot:MEPH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MEPH_ECOLI pepwheel swissprot:MEPH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MEPH_ECOLI pepwindow swissprot:MEPH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MEPH_ECOLI sigcleave swissprot:MEPH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MEPH_ECOLI ## Database ID URL or Descriptions # AltName Exoribonuclease T {ECO:0000255|HAMAP-Rule MF_00157} # BRENDA 3.1.13 2026 # BioGrid 4260267 143 # CDD cd06134 RNaseT # COFACTOR RNT_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_00157, ECO 0000269|PubMed 12364334, ECO 0000269|PubMed 17437714, ECO 0000269|PubMed 21317904, ECO 0000269|PubMed 22718982}; Note=Binds two Mg(2+) per subunit. The active form of the enzyme binds two Mg(2+) ions in its active site. The first Mg(2+) forms only one salt bridge with the protein. {ECO 0000255|HAMAP- Rule MF_00157, ECO 0000269|PubMed 12364334, ECO 0000269|PubMed 17437714, ECO 0000269|PubMed 21317904, ECO 0000269|PubMed 22718982}; # DISRUPTION PHENOTYPE Required for optimal growth. {ECO:0000269|PubMed 21317904}. # EcoGene EG11547 rnt # FUNCTION RNT_ECOLI Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis, especially in strains lacking other exoribonucleases. {ECO 0000255|HAMAP-Rule MF_00157, ECO 0000269|PubMed 12364334, ECO 0000269|PubMed 17437714, ECO 0000269|PubMed 21317904}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0003676 nucleic acid binding; IEA:InterPro. # GO_function GO:0016896 exoribonuclease activity, producing 5'-phosphomonoesters; IEA:UniProtKB-HAMAP. # GO_process GO:0008033 tRNA processing; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0004518 nuclease activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # Gene3D 3.30.420.10 -; 1. # HAMAP MF_00157 RNase_T # IntAct P30014 2 # InterPro IPR005987 RNase_T # InterPro IPR012337 RNaseH-like_dom # InterPro IPR013520 Exonuclease_RNaseT/DNA_pol3 # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # MISCELLANEOUS RNT_ECOLI Member of the DEDD group of RNAses that are characterized by the presence of four acidic residues in the active site. These residues are conserved even when the proteins have highly divergent sequences. # Organism RNT_ECOLI Escherichia coli (strain K12) # PATRIC 32118606 VBIEscCol129921_1723 # PDB 2IS3 X-ray; 3.10 A; A/B/C/D=1-215 # PDB 3NGY X-ray; 2.20 A; A/B/C/D=1-215 # PDB 3NGZ X-ray; 2.10 A; A/B=1-215 # PDB 3NH0 X-ray; 2.30 A; A/B=1-215 # PDB 3NH1 X-ray; 2.11 A; A/B/C/D=1-215 # PDB 3NH2 X-ray; 2.30 A; A/B/E/F=1-215 # PDB 3V9S X-ray; 2.10 A; A/B=1-215 # PDB 3V9U X-ray; 2.30 A; A/B/C/D=1-215 # PDB 3V9W X-ray; 1.70 A; A/B/C/D=1-215 # PDB 3V9X X-ray; 1.90 A; A/B/C/D=1-215 # PDB 3V9Z X-ray; 1.80 A; A/B=1-215 # PDB 3VA0 X-ray; 2.20 A; A/B=1-215 # PDB 3VA3 X-ray; 2.71 A; A/B=1-215 # PDB 4KAZ X-ray; 1.90 A; A=1-215 # PDB 4KB0 X-ray; 2.00 A; A/B=1-215 # PDB 4KB1 X-ray; 1.80 A; A/B=1-215 # PIR A45065 A45065 # Pfam PF00929 RNase_T # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Ribonuclease T {ECO:0000255|HAMAP-Rule MF_00157} # RefSeq NP_416169 NC_000913.3 # RefSeq WP_001282283 NZ_LN832404.1 # SIMILARITY Belongs to the RNase T family. {ECO:0000255|HAMAP- Rule MF_00157}. # SIMILARITY Contains 1 exonuclease domain. {ECO:0000255|HAMAP- Rule MF_00157}. # SMART SM00479 EXOIII # SUBUNIT RNT_ECOLI Homodimer. {ECO 0000255|HAMAP-Rule MF_00157, ECO 0000269|PubMed 17437714, ECO 0000269|PubMed 21317904}. # SUPFAM SSF53098 SSF53098 # TIGRFAMs TIGR01298 RNaseT # eggNOG COG0847 LUCA # eggNOG ENOG4105DH5 Bacteria BLAST swissprot:RNT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RNT_ECOLI BioCyc ECOL316407:JW1644-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1644-MONOMER BioCyc EcoCyc:EG11547-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11547-MONOMER BioCyc MetaCyc:EG11547-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11547-MONOMER COG COG0847 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0847 DIP DIP-10734N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10734N DOI 10.1016/j.str.2007.02.004 http://dx.doi.org/10.1016/j.str.2007.02.004 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nchembio.524 http://dx.doi.org/10.1038/nchembio.524 DOI 10.1074/jbc.M207706200 http://dx.doi.org/10.1074/jbc.M207706200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/gks548 http://dx.doi.org/10.1093/nar/gks548 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.13.- {ECO:0000255|HAMAP-Rule:MF_00157} http://www.genome.jp/dbget-bin/www_bget?EC:3.1.13.- {ECO:0000255|HAMAP-Rule:MF_00157} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L01622 http://www.ebi.ac.uk/ena/data/view/L01622 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.13.- {ECO:0000255|HAMAP-Rule:MF_00157} http://enzyme.expasy.org/EC/3.1.13.- {ECO:0000255|HAMAP-Rule:MF_00157} EchoBASE EB1509 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1509 EcoGene EG11547 http://www.ecogene.org/geneInfo.php?eg_id=EG11547 EnsemblBacteria AAC74724 http://www.ensemblgenomes.org/id/AAC74724 EnsemblBacteria AAC74724 http://www.ensemblgenomes.org/id/AAC74724 EnsemblBacteria BAA15418 http://www.ensemblgenomes.org/id/BAA15418 EnsemblBacteria BAA15418 http://www.ensemblgenomes.org/id/BAA15418 EnsemblBacteria BAA15418 http://www.ensemblgenomes.org/id/BAA15418 EnsemblBacteria b1652 http://www.ensemblgenomes.org/id/b1652 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0003676 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003676 GO_function GO:0016896 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016896 GO_process GO:0008033 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008033 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 Gene3D 3.30.420.10 http://www.cathdb.info/version/latest/superfamily/3.30.420.10 GeneID 946159 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946159 HAMAP MF_00157 http://hamap.expasy.org/unirule/MF_00157 HOGENOM HOG000279358 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000279358&db=HOGENOM6 InParanoid P30014 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30014 IntAct P30014 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P30014* IntEnz 3.1.13.- {ECO:0000255|HAMAP-Rule:MF_00157} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.13.- {ECO:0000255|HAMAP-Rule:MF_00157} InterPro IPR005987 http://www.ebi.ac.uk/interpro/entry/IPR005987 InterPro IPR012337 http://www.ebi.ac.uk/interpro/entry/IPR012337 InterPro IPR013520 http://www.ebi.ac.uk/interpro/entry/IPR013520 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW1644 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1644 KEGG_Gene eco:b1652 http://www.genome.jp/dbget-bin/www_bget?eco:b1652 KEGG_Orthology KO:K03683 http://www.genome.jp/dbget-bin/www_bget?KO:K03683 MINT MINT-1248458 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1248458 OMA CYMVNHL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CYMVNHL PDB 2IS3 http://www.ebi.ac.uk/pdbe-srv/view/entry/2IS3 PDB 3NGY http://www.ebi.ac.uk/pdbe-srv/view/entry/3NGY PDB 3NGZ http://www.ebi.ac.uk/pdbe-srv/view/entry/3NGZ PDB 3NH0 http://www.ebi.ac.uk/pdbe-srv/view/entry/3NH0 PDB 3NH1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3NH1 PDB 3NH2 http://www.ebi.ac.uk/pdbe-srv/view/entry/3NH2 PDB 3V9S http://www.ebi.ac.uk/pdbe-srv/view/entry/3V9S PDB 3V9U http://www.ebi.ac.uk/pdbe-srv/view/entry/3V9U PDB 3V9W http://www.ebi.ac.uk/pdbe-srv/view/entry/3V9W PDB 3V9X http://www.ebi.ac.uk/pdbe-srv/view/entry/3V9X PDB 3V9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3V9Z PDB 3VA0 http://www.ebi.ac.uk/pdbe-srv/view/entry/3VA0 PDB 3VA3 http://www.ebi.ac.uk/pdbe-srv/view/entry/3VA3 PDB 4KAZ http://www.ebi.ac.uk/pdbe-srv/view/entry/4KAZ PDB 4KB0 http://www.ebi.ac.uk/pdbe-srv/view/entry/4KB0 PDB 4KB1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4KB1 PDBsum 2IS3 http://www.ebi.ac.uk/pdbsum/2IS3 PDBsum 3NGY http://www.ebi.ac.uk/pdbsum/3NGY PDBsum 3NGZ http://www.ebi.ac.uk/pdbsum/3NGZ PDBsum 3NH0 http://www.ebi.ac.uk/pdbsum/3NH0 PDBsum 3NH1 http://www.ebi.ac.uk/pdbsum/3NH1 PDBsum 3NH2 http://www.ebi.ac.uk/pdbsum/3NH2 PDBsum 3V9S http://www.ebi.ac.uk/pdbsum/3V9S PDBsum 3V9U http://www.ebi.ac.uk/pdbsum/3V9U PDBsum 3V9W http://www.ebi.ac.uk/pdbsum/3V9W PDBsum 3V9X http://www.ebi.ac.uk/pdbsum/3V9X PDBsum 3V9Z http://www.ebi.ac.uk/pdbsum/3V9Z PDBsum 3VA0 http://www.ebi.ac.uk/pdbsum/3VA0 PDBsum 3VA3 http://www.ebi.ac.uk/pdbsum/3VA3 PDBsum 4KAZ http://www.ebi.ac.uk/pdbsum/4KAZ PDBsum 4KB0 http://www.ebi.ac.uk/pdbsum/4KB0 PDBsum 4KB1 http://www.ebi.ac.uk/pdbsum/4KB1 PSORT swissprot:RNT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RNT_ECOLI PSORT-B swissprot:RNT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RNT_ECOLI PSORT2 swissprot:RNT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RNT_ECOLI Pfam PF00929 http://pfam.xfam.org/family/PF00929 Phobius swissprot:RNT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RNT_ECOLI PhylomeDB P30014 http://phylomedb.org/?seqid=P30014 ProteinModelPortal P30014 http://www.proteinmodelportal.org/query/uniprot/P30014 PubMed 12364334 http://www.ncbi.nlm.nih.gov/pubmed/12364334 PubMed 1460056 http://www.ncbi.nlm.nih.gov/pubmed/1460056 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1704882 http://www.ncbi.nlm.nih.gov/pubmed/1704882 PubMed 17437714 http://www.ncbi.nlm.nih.gov/pubmed/17437714 PubMed 21317904 http://www.ncbi.nlm.nih.gov/pubmed/21317904 PubMed 22718982 http://www.ncbi.nlm.nih.gov/pubmed/22718982 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416169 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416169 RefSeq WP_001282283 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001282283 SMART SM00479 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00479 SMR P30014 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P30014 STRING 511145.b1652 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1652&targetmode=cogs STRING COG0847 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0847&targetmode=cogs SUPFAM SSF53098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098 TIGRFAMs TIGR01298 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01298 UniProtKB RNT_ECOLI http://www.uniprot.org/uniprot/RNT_ECOLI UniProtKB-AC P30014 http://www.uniprot.org/uniprot/P30014 charge swissprot:RNT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RNT_ECOLI eggNOG COG0847 http://eggnogapi.embl.de/nog_data/html/tree/COG0847 eggNOG ENOG4105DH5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DH5 epestfind swissprot:RNT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RNT_ECOLI garnier swissprot:RNT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RNT_ECOLI helixturnhelix swissprot:RNT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RNT_ECOLI hmoment swissprot:RNT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RNT_ECOLI iep swissprot:RNT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RNT_ECOLI inforesidue swissprot:RNT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RNT_ECOLI octanol swissprot:RNT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RNT_ECOLI pepcoil swissprot:RNT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RNT_ECOLI pepdigest swissprot:RNT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RNT_ECOLI pepinfo swissprot:RNT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RNT_ECOLI pepnet swissprot:RNT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RNT_ECOLI pepstats swissprot:RNT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RNT_ECOLI pepwheel swissprot:RNT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RNT_ECOLI pepwindow swissprot:RNT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RNT_ECOLI sigcleave swissprot:RNT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RNT_ECOLI ## Database ID URL or Descriptions # BioGrid 4259526 176 # EcoGene EG13338 yafZ # IntAct P77206 3 # InterPro IPR026325 DUF932 # Organism YAFZ_ECOLI Escherichia coli (strain K12) # PATRIC 32115623 VBIEscCol129921_0255 # PIR D64750 D64750 # Pfam PF06067 DUF932 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAFZ_ECOLI UPF0380 protein YafZ # RefSeq NP_414786 NC_000913.3 # RefSeq WP_000197389 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB08671.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the UPF0380 family. {ECO 0000305}. # eggNOG ENOG4106H6R Bacteria # eggNOG ENOG410XPYV LUCA BLAST swissprot:YAFZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAFZ_ECOLI BioCyc ECOL316407:JW0242-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0242-MONOMER BioCyc EcoCyc:G6127-MONOMER http://biocyc.org/getid?id=EcoCyc:G6127-MONOMER DIP DIP-11229N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11229N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EchoBASE EB3122 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3122 EcoGene EG13338 http://www.ecogene.org/geneInfo.php?eg_id=EG13338 EnsemblBacteria AAC73355 http://www.ensemblgenomes.org/id/AAC73355 EnsemblBacteria AAC73355 http://www.ensemblgenomes.org/id/AAC73355 EnsemblBacteria BAA77921 http://www.ensemblgenomes.org/id/BAA77921 EnsemblBacteria BAA77921 http://www.ensemblgenomes.org/id/BAA77921 EnsemblBacteria BAA77921 http://www.ensemblgenomes.org/id/BAA77921 EnsemblBacteria b0252 http://www.ensemblgenomes.org/id/b0252 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945373 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945373 HOGENOM HOG000222632 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000222632&db=HOGENOM6 IntAct P77206 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77206* InterPro IPR026325 http://www.ebi.ac.uk/interpro/entry/IPR026325 KEGG_Gene ecj:JW0242 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0242 KEGG_Gene eco:b0252 http://www.genome.jp/dbget-bin/www_bget?eco:b0252 OMA KRAQTRA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KRAQTRA PSORT swissprot:YAFZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAFZ_ECOLI PSORT-B swissprot:YAFZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAFZ_ECOLI PSORT2 swissprot:YAFZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAFZ_ECOLI Pfam PF06067 http://pfam.xfam.org/family/PF06067 Phobius swissprot:YAFZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAFZ_ECOLI PhylomeDB P77206 http://phylomedb.org/?seqid=P77206 ProteinModelPortal P77206 http://www.proteinmodelportal.org/query/uniprot/P77206 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414786 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414786 RefSeq WP_000197389 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000197389 STRING 511145.b0252 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0252&targetmode=cogs UniProtKB YAFZ_ECOLI http://www.uniprot.org/uniprot/YAFZ_ECOLI UniProtKB-AC P77206 http://www.uniprot.org/uniprot/P77206 charge swissprot:YAFZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAFZ_ECOLI eggNOG ENOG4106H6R http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106H6R eggNOG ENOG410XPYV http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPYV epestfind swissprot:YAFZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAFZ_ECOLI garnier swissprot:YAFZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAFZ_ECOLI helixturnhelix swissprot:YAFZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAFZ_ECOLI hmoment swissprot:YAFZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAFZ_ECOLI iep swissprot:YAFZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAFZ_ECOLI inforesidue swissprot:YAFZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAFZ_ECOLI octanol swissprot:YAFZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAFZ_ECOLI pepcoil swissprot:YAFZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAFZ_ECOLI pepdigest swissprot:YAFZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAFZ_ECOLI pepinfo swissprot:YAFZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAFZ_ECOLI pepnet swissprot:YAFZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAFZ_ECOLI pepstats swissprot:YAFZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAFZ_ECOLI pepwheel swissprot:YAFZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAFZ_ECOLI pepwindow swissprot:YAFZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAFZ_ECOLI sigcleave swissprot:YAFZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAFZ_ECOLI ## Database ID URL or Descriptions # BioGrid 4260739 180 # CDD cd09670 Cse2_I-E # DISRUPTION PHENOTYPE CSE2_ECOLI Loss of resistance to bacteriophage lambda infection, loss of plasmid silencing. Increased levels of 57 nucleotide crRNA and also 2 and 3 spacer-repeat units. {ECO 0000269|PubMed 18703739, ECO 0000269|PubMed 21255106, ECO 0000269|PubMed 21460843}. # EcoGene EG13118 casB # FUNCTION CSE2_ECOLI A component of Cascade, which participates in CRISPR interference, the third stage of CRISPR immunity. Cascade binds both crRNA and in a sequence-specific manner negatively supercoiled dsDNA target. This leads to the formation of an R-loop in which the crRNA binds the target DNA, displacing the noncomplementary strand. Cas3 is recruited to Cascade, nicks target DNA and then unwinds and cleaves the target, leading to DNA degradation and invader neutralization. # FUNCTION CSE2_ECOLI CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). # GO_component GO:0043234 protein complex; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0003723 RNA binding; IEA:UniProtKB-KW. # GO_process GO:0051607 defense response to virus; IMP:EcoCyc. # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0003723 RNA binding # GOslim_process GO:0002376 immune system process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0044403 symbiosis, encompassing mutualism through parasitism # INDUCTION CSE2_ECOLI Repressed by H-NS, activated by LeuO. Activated by the BaeSR two-component regulatory system, possibly due to envelope stress. Part of the casABCDE-ygbT-ygbF operon. {ECO 0000269|PubMed 19429622, ECO 0000269|PubMed 20132443, ECO 0000269|PubMed 21255106}. # IntAct P76632 9 # InterPro IPR013382 CRISPR-assoc_prot_Cse2 # MASS SPECTROMETRY Mass=21261.5; Mass_error=1.1; Method=Unknown; Range=1-160; Evidence={ECO:0000269|PubMed 21460843}; # Organism CSE2_ECOLI Escherichia coli (strain K12) # PATRIC 32120928 VBIEscCol129921_2856 # PDB 4QYZ X-ray; 3.03 A; B/C=1-160 # PDB 4TVX X-ray; 3.24 A; J/K/V/W=1-160 # PDB 4U7U X-ray; 3.00 A; B/C/N/O=1-160 # PDB 5CD4 X-ray; 3.20 A; J/K/V/W=1-160 # PDB 5H9E X-ray; 3.21 A; B/C=1-160 # PDB 5H9F X-ray; 2.45 A; B/C=1-160 # PIR C65057 C65057 # Pfam PF09485 CRISPR_Cse2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CSE2_ECOLI CRISPR system Cascade subunit CasB # RefSeq NP_417239 NC_000913.3 # RefSeq WP_000752800 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA69269.1; Type=Frameshift; Positions=130; Evidence={ECO 0000305}; # SIMILARITY Belongs to the CRISPR-associated CasB/Cse2 family. {ECO 0000305}. # SUBUNIT CSE2_ECOLI Homodimer. Part of the Cascade ribonucleoprotein complex, with stoichiometry CasA(1),CasB(2), CasC(6),CasD(1),CasE(1)- crRNA(1). The CasB homodimer forms a cleft that cradles the 3' end of the crRNA. Interacts directly with crRNA, CasA, CasC and CasE. Stable subcomplexes of CasBCDE-crRNA and CasCDE-crRNA also form, both of which are able to bind target dsDNA. Binding of target ssRNA or dsDNA causes a conformational change in the Cascade complex. {ECO 0000269|PubMed 18703739, ECO 0000269|PubMed 21255106, ECO 0000269|PubMed 21460843, ECO 0000269|PubMed 21938068, ECO 0000269|PubMed 22521689}. # TIGRFAMs TIGR02548 casB_cse2 # eggNOG ENOG41061HK Bacteria # eggNOG ENOG41126UY LUCA BLAST swissprot:CSE2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CSE2_ECOLI BioCyc ECOL316407:JW2729-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2729-MONOMER BioCyc EcoCyc:G7429-MONOMER http://biocyc.org/getid?id=EcoCyc:G7429-MONOMER BioCyc MetaCyc:G7429-MONOMER http://biocyc.org/getid?id=MetaCyc:G7429-MONOMER DIP DIP-12127N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12127N DOI 10.1016/j.molcel.2012.03.018 http://dx.doi.org/10.1016/j.molcel.2012.03.018 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature10402 http://dx.doi.org/10.1038/nature10402 DOI 10.1038/nsmb.2019 http://dx.doi.org/10.1038/nsmb.2019 DOI 10.1111/j.1365-2958.2010.07073.x http://dx.doi.org/10.1111/j.1365-2958.2010.07073.x DOI 10.1111/j.1365-2958.2010.07482.x http://dx.doi.org/10.1111/j.1365-2958.2010.07482.x DOI 10.1126/science.1159689 http://dx.doi.org/10.1126/science.1159689 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00108-09 http://dx.doi.org/10.1128/JB.00108-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EchoBASE EB2919 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2919 EcoGene EG13118 http://www.ecogene.org/geneInfo.php?eg_id=EG13118 EnsemblBacteria AAC75801 http://www.ensemblgenomes.org/id/AAC75801 EnsemblBacteria AAC75801 http://www.ensemblgenomes.org/id/AAC75801 EnsemblBacteria BAE76836 http://www.ensemblgenomes.org/id/BAE76836 EnsemblBacteria BAE76836 http://www.ensemblgenomes.org/id/BAE76836 EnsemblBacteria BAE76836 http://www.ensemblgenomes.org/id/BAE76836 EnsemblBacteria b2759 http://www.ensemblgenomes.org/id/b2759 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_process GO:0051607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051607 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_process GO:0002376 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0044403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403 GeneID 947223 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947223 HOGENOM HOG000009769 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009769&db=HOGENOM6 InParanoid P76632 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76632 IntAct P76632 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76632* InterPro IPR013382 http://www.ebi.ac.uk/interpro/entry/IPR013382 KEGG_Gene ecj:JW2729 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2729 KEGG_Gene eco:b2759 http://www.genome.jp/dbget-bin/www_bget?eco:b2759 OMA QNWSELD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QNWSELD PDB 4QYZ http://www.ebi.ac.uk/pdbe-srv/view/entry/4QYZ PDB 4TVX http://www.ebi.ac.uk/pdbe-srv/view/entry/4TVX PDB 4U7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U7U PDB 5CD4 http://www.ebi.ac.uk/pdbe-srv/view/entry/5CD4 PDB 5H9E http://www.ebi.ac.uk/pdbe-srv/view/entry/5H9E PDB 5H9F http://www.ebi.ac.uk/pdbe-srv/view/entry/5H9F PDBsum 4QYZ http://www.ebi.ac.uk/pdbsum/4QYZ PDBsum 4TVX http://www.ebi.ac.uk/pdbsum/4TVX PDBsum 4U7U http://www.ebi.ac.uk/pdbsum/4U7U PDBsum 5CD4 http://www.ebi.ac.uk/pdbsum/5CD4 PDBsum 5H9E http://www.ebi.ac.uk/pdbsum/5H9E PDBsum 5H9F http://www.ebi.ac.uk/pdbsum/5H9F PSORT swissprot:CSE2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CSE2_ECOLI PSORT-B swissprot:CSE2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CSE2_ECOLI PSORT2 swissprot:CSE2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CSE2_ECOLI Pfam PF09485 http://pfam.xfam.org/family/PF09485 Phobius swissprot:CSE2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CSE2_ECOLI ProteinModelPortal P76632 http://www.proteinmodelportal.org/query/uniprot/P76632 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18703739 http://www.ncbi.nlm.nih.gov/pubmed/18703739 PubMed 19429622 http://www.ncbi.nlm.nih.gov/pubmed/19429622 PubMed 20132443 http://www.ncbi.nlm.nih.gov/pubmed/20132443 PubMed 21255106 http://www.ncbi.nlm.nih.gov/pubmed/21255106 PubMed 21460843 http://www.ncbi.nlm.nih.gov/pubmed/21460843 PubMed 21938068 http://www.ncbi.nlm.nih.gov/pubmed/21938068 PubMed 22521689 http://www.ncbi.nlm.nih.gov/pubmed/22521689 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417239 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417239 RefSeq WP_000752800 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000752800 SMR P76632 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76632 STRING 511145.b2759 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2759&targetmode=cogs TIGRFAMs TIGR02548 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02548 UniProtKB CSE2_ECOLI http://www.uniprot.org/uniprot/CSE2_ECOLI UniProtKB-AC P76632 http://www.uniprot.org/uniprot/P76632 charge swissprot:CSE2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CSE2_ECOLI eggNOG ENOG41061HK http://eggnogapi.embl.de/nog_data/html/tree/ENOG41061HK eggNOG ENOG41126UY http://eggnogapi.embl.de/nog_data/html/tree/ENOG41126UY epestfind swissprot:CSE2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CSE2_ECOLI garnier swissprot:CSE2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CSE2_ECOLI helixturnhelix swissprot:CSE2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CSE2_ECOLI hmoment swissprot:CSE2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CSE2_ECOLI iep swissprot:CSE2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CSE2_ECOLI inforesidue swissprot:CSE2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CSE2_ECOLI octanol swissprot:CSE2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CSE2_ECOLI pepcoil swissprot:CSE2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CSE2_ECOLI pepdigest swissprot:CSE2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CSE2_ECOLI pepinfo swissprot:CSE2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CSE2_ECOLI pepnet swissprot:CSE2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CSE2_ECOLI pepstats swissprot:CSE2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CSE2_ECOLI pepwheel swissprot:CSE2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CSE2_ECOLI pepwindow swissprot:CSE2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CSE2_ECOLI sigcleave swissprot:CSE2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CSE2_ECOLI ## Database ID URL or Descriptions # BioGrid 4261045 3 # EcoGene EG11976 fliQ # FUNCTION FLIQ_ECOLI Required for the assembly of the rivet at the earliest stage of flagellar biosynthesis. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0009425 bacterial-type flagellum basal body; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0009306 protein secretion; IEA:InterPro. # GO_process GO:0044780 bacterial-type flagellum assembly; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006810 transport # GOslim_process GO:0022607 cellular component assembly # InterPro IPR002191 Bac_export_3 # InterPro IPR006305 FliQ # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko02040 Flagellar assembly # Organism FLIQ_ECOLI Escherichia coli (strain K12) # PATRIC 32119227 VBIEscCol129921_2028 # PIR C36869 C36869 # PIRSF PIRSF004669 FliQ # PRINTS PR00952 TYPE3IMQPROT # Pfam PF01313 Bac_export_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FLIQ_ECOLI Flagellar biosynthetic protein FliQ # RefSeq NP_416459 NC_000913.3 # RefSeq WP_000187358 NZ_LN832404.1 # SIMILARITY Belongs to the FliQ/MopD/SpaQ family. {ECO 0000305}. # SUBCELLULAR LOCATION FLIQ_ECOLI Cell inner membrane {ECO 0000305}; Multi- pass membrane protein {ECO 0000305}. Bacterial flagellum basal body {ECO 0000250}. # TIGRFAMs TIGR01402 fliQ # eggNOG COG1987 LUCA BLAST swissprot:FLIQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLIQ_ECOLI BioCyc ECOL316407:JW1933-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1933-MONOMER BioCyc EcoCyc:EG11976-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11976-MONOMER COG COG1987 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1987 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L22182 http://www.ebi.ac.uk/ena/data/view/L22182 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1919 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1919 EcoGene EG11976 http://www.ecogene.org/geneInfo.php?eg_id=EG11976 EnsemblBacteria AAC75016 http://www.ensemblgenomes.org/id/AAC75016 EnsemblBacteria AAC75016 http://www.ensemblgenomes.org/id/AAC75016 EnsemblBacteria BAA15774 http://www.ensemblgenomes.org/id/BAA15774 EnsemblBacteria BAA15774 http://www.ensemblgenomes.org/id/BAA15774 EnsemblBacteria BAA15774 http://www.ensemblgenomes.org/id/BAA15774 EnsemblBacteria b1949 http://www.ensemblgenomes.org/id/b1949 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0009425 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009425 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0009306 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009306 GO_process GO:0044780 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044780 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GeneID 946463 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946463 HOGENOM HOG000253672 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000253672&db=HOGENOM6 InParanoid P0AC07 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AC07 IntAct P0AC07 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AC07* InterPro IPR002191 http://www.ebi.ac.uk/interpro/entry/IPR002191 InterPro IPR006305 http://www.ebi.ac.uk/interpro/entry/IPR006305 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW1933 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1933 KEGG_Gene eco:b1949 http://www.genome.jp/dbget-bin/www_bget?eco:b1949 KEGG_Orthology KO:K02420 http://www.genome.jp/dbget-bin/www_bget?KO:K02420 KEGG_Pathway ko02040 http://www.genome.jp/kegg-bin/show_pathway?ko02040 OMA FRDALWL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FRDALWL PRINTS PR00952 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00952 PSORT swissprot:FLIQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLIQ_ECOLI PSORT-B swissprot:FLIQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLIQ_ECOLI PSORT2 swissprot:FLIQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLIQ_ECOLI Pfam PF01313 http://pfam.xfam.org/family/PF01313 Phobius swissprot:FLIQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLIQ_ECOLI PhylomeDB P0AC07 http://phylomedb.org/?seqid=P0AC07 ProteinModelPortal P0AC07 http://www.proteinmodelportal.org/query/uniprot/P0AC07 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8282695 http://www.ncbi.nlm.nih.gov/pubmed/8282695 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416459 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416459 RefSeq WP_000187358 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000187358 STRING 511145.b1949 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1949&targetmode=cogs STRING COG1987 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1987&targetmode=cogs TIGRFAMs TIGR01402 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01402 UniProtKB FLIQ_ECOLI http://www.uniprot.org/uniprot/FLIQ_ECOLI UniProtKB-AC P0AC07 http://www.uniprot.org/uniprot/P0AC07 charge swissprot:FLIQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLIQ_ECOLI eggNOG COG1987 http://eggnogapi.embl.de/nog_data/html/tree/COG1987 epestfind swissprot:FLIQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLIQ_ECOLI garnier swissprot:FLIQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLIQ_ECOLI helixturnhelix swissprot:FLIQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLIQ_ECOLI hmoment swissprot:FLIQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLIQ_ECOLI iep swissprot:FLIQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLIQ_ECOLI inforesidue swissprot:FLIQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLIQ_ECOLI octanol swissprot:FLIQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLIQ_ECOLI pepcoil swissprot:FLIQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLIQ_ECOLI pepdigest swissprot:FLIQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLIQ_ECOLI pepinfo swissprot:FLIQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLIQ_ECOLI pepnet swissprot:FLIQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLIQ_ECOLI pepstats swissprot:FLIQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLIQ_ECOLI pepwheel swissprot:FLIQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLIQ_ECOLI pepwindow swissprot:FLIQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLIQ_ECOLI sigcleave swissprot:FLIQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLIQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4262483 130 # EcoGene EG12931 yhgE # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR025291 DUF4153 # Organism YHGE_ECOLI Escherichia coli (strain K12) # PATRIC 32122238 VBIEscCol129921_3496 # PIR E65135 E65135 # Pfam PF13687 DUF4153 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHGE_ECOLI Uncharacterized protein YhgE # RefSeq NP_417861 NC_000913.3 # RefSeq WP_000370879 NZ_LN832404.1 # SIMILARITY To B.subtilis YrdB. {ECO 0000305}. # SUBCELLULAR LOCATION YHGE_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # TCDB 9.B.65.1 the putative transporter (yhge) family # eggNOG ENOG4108MAJ Bacteria # eggNOG ENOG410XS9K LUCA BLAST swissprot:YHGE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHGE_ECOLI BioCyc ECOL316407:JW3365-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3365-MONOMER BioCyc EcoCyc:G7745-MONOMER http://biocyc.org/getid?id=EcoCyc:G7745-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2767 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2767 EcoGene EG12931 http://www.ecogene.org/geneInfo.php?eg_id=EG12931 EnsemblBacteria AAC76427 http://www.ensemblgenomes.org/id/AAC76427 EnsemblBacteria AAC76427 http://www.ensemblgenomes.org/id/AAC76427 EnsemblBacteria BAE77889 http://www.ensemblgenomes.org/id/BAE77889 EnsemblBacteria BAE77889 http://www.ensemblgenomes.org/id/BAE77889 EnsemblBacteria BAE77889 http://www.ensemblgenomes.org/id/BAE77889 EnsemblBacteria b3402 http://www.ensemblgenomes.org/id/b3402 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 947651 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947651 HOGENOM HOG000125565 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125565&db=HOGENOM6 IntAct P45804 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45804* InterPro IPR025291 http://www.ebi.ac.uk/interpro/entry/IPR025291 KEGG_Gene ecj:JW3365 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3365 KEGG_Gene eco:b3402 http://www.genome.jp/dbget-bin/www_bget?eco:b3402 OMA WRISVES http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WRISVES PSORT swissprot:YHGE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHGE_ECOLI PSORT-B swissprot:YHGE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHGE_ECOLI PSORT2 swissprot:YHGE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHGE_ECOLI Pfam PF13687 http://pfam.xfam.org/family/PF13687 Phobius swissprot:YHGE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHGE_ECOLI ProteinModelPortal P45804 http://www.proteinmodelportal.org/query/uniprot/P45804 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417861 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417861 RefSeq WP_000370879 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000370879 STRING 511145.b3402 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3402&targetmode=cogs TCDB 9.B.65.1 http://www.tcdb.org/search/result.php?tc=9.B.65.1 UniProtKB YHGE_ECOLI http://www.uniprot.org/uniprot/YHGE_ECOLI UniProtKB-AC P45804 http://www.uniprot.org/uniprot/P45804 charge swissprot:YHGE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHGE_ECOLI eggNOG ENOG4108MAJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MAJ eggNOG ENOG410XS9K http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XS9K epestfind swissprot:YHGE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHGE_ECOLI garnier swissprot:YHGE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHGE_ECOLI helixturnhelix swissprot:YHGE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHGE_ECOLI hmoment swissprot:YHGE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHGE_ECOLI iep swissprot:YHGE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHGE_ECOLI inforesidue swissprot:YHGE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHGE_ECOLI octanol swissprot:YHGE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHGE_ECOLI pepcoil swissprot:YHGE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHGE_ECOLI pepdigest swissprot:YHGE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHGE_ECOLI pepinfo swissprot:YHGE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHGE_ECOLI pepnet swissprot:YHGE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHGE_ECOLI pepstats swissprot:YHGE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHGE_ECOLI pepwheel swissprot:YHGE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHGE_ECOLI pepwindow swissprot:YHGE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHGE_ECOLI sigcleave swissprot:YHGE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHGE_ECOLI ## Database ID URL or Descriptions # AltName TESA_ECOLI Lecithinase B # AltName TESA_ECOLI Lysophospholipase L1 # AltName TESA_ECOLI Protease I # BRENDA 3.1.1 2026 # BRENDA 3.1.2 2026 # BioGrid 4259854 5 # CATALYTIC ACTIVITY TESA_ECOLI 2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate. # EcoGene EG11542 tesA # FUNCTION TESA_ECOLI Hydrolyzes only long chain acyl thioesters (C12-C18). Specificity similar to chymotrypsin. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0004620 phospholipase activity; IDA:EcoCyc. # GO_function GO:0004622 lysophospholipase activity; IDA:EcoCyc. # GO_function GO:0008233 peptidase activity; IDA:EcoCyc. # GO_function GO:0016290 palmitoyl-CoA hydrolase activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0047617 acyl-CoA hydrolase activity; IDA:EcoCyc. # GO_process GO:0006629 lipid metabolic process; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008233 peptidase activity # GOslim_process GO:0006629 lipid metabolic process # Gene3D 3.40.50.1110 -; 1. # InterPro IPR008265 Lipase_GDSL_AS # InterPro IPR013830 SGNH_hydro # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01004 Lipid biosynthesis proteins # KEGG_Pathway ko01040 Biosynthesis of unsaturated fatty acids # Organism TESA_ECOLI Escherichia coli (strain K12) # PATRIC 32116147 VBIEscCol129921_0515 # PDB 1IVN X-ray; 1.90 A; A=27-208 # PDB 1J00 X-ray; 2.00 A; A=27-208 # PDB 1JRL X-ray; 1.95 A; A=27-208 # PDB 1U8U X-ray; 2.08 A; A=27-208 # PDB 1V2G X-ray; 2.00 A; A=27-208 # PIR A49699 A49699 # PIR PX0045 PX0045 # PROSITE PS01098 LIPASE_GDSL_SER # Pfam PF13472 Lipase_GDSL_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TESA_ECOLI Acyl-CoA thioesterase I # RefSeq NP_415027 NC_000913.3 # SEQUENCE CAUTION Sequence=AAB40248.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the 'GDSL' lipolytic enzyme family. {ECO 0000305}. # SUBCELLULAR LOCATION TESA_ECOLI Periplasm. # SUBUNIT TESA_ECOLI Monomer. {ECO 0000269|PubMed 12842470, ECO 0000269|PubMed 15697222}. # SUPFAM SSF52266 SSF52266 # eggNOG COG2755 LUCA # eggNOG ENOG4108UJV Bacteria BLAST swissprot:TESA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TESA_ECOLI BioCyc ECOL316407:JW0483-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0483-MONOMER BioCyc EcoCyc:THIOESTERI-MONOMER http://biocyc.org/getid?id=EcoCyc:THIOESTERI-MONOMER BioCyc MetaCyc:THIOESTERI-MONOMER http://biocyc.org/getid?id=MetaCyc:THIOESTERI-MONOMER COG COG2755 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2755 DOI 10.1016/S0022-2836(03)00637-5 http://dx.doi.org/10.1016/S0022-2836(03)00637-5 DOI 10.1021/bi048109x http://dx.doi.org/10.1021/bi048109x DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/BJ20051645 http://dx.doi.org/10.1042/BJ20051645 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.1.5 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.1.5 EC_number EC:3.1.2.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.2.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D13180 http://www.ebi.ac.uk/ena/data/view/D13180 EMBL L06182 http://www.ebi.ac.uk/ena/data/view/L06182 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 ENZYME 3.1.1.5 http://enzyme.expasy.org/EC/3.1.1.5 ENZYME 3.1.2.- http://enzyme.expasy.org/EC/3.1.2.- EchoBASE EB1504 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1504 EcoGene EG11542 http://www.ecogene.org/geneInfo.php?eg_id=EG11542 EnsemblBacteria AAC73596 http://www.ensemblgenomes.org/id/AAC73596 EnsemblBacteria AAC73596 http://www.ensemblgenomes.org/id/AAC73596 EnsemblBacteria BAE76273 http://www.ensemblgenomes.org/id/BAE76273 EnsemblBacteria BAE76273 http://www.ensemblgenomes.org/id/BAE76273 EnsemblBacteria BAE76273 http://www.ensemblgenomes.org/id/BAE76273 EnsemblBacteria b0494 http://www.ensemblgenomes.org/id/b0494 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0004620 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004620 GO_function GO:0004622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004622 GO_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GO_function GO:0016290 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016290 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0047617 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047617 GO_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 Gene3D 3.40.50.1110 http://www.cathdb.info/version/latest/superfamily/3.40.50.1110 GeneID 945127 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945127 HOGENOM HOG000261382 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261382&db=HOGENOM6 InParanoid P0ADA1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADA1 IntEnz 3.1.1.5 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.1.5 IntEnz 3.1.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.2 InterPro IPR008265 http://www.ebi.ac.uk/interpro/entry/IPR008265 InterPro IPR013830 http://www.ebi.ac.uk/interpro/entry/IPR013830 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01004 http://www.genome.jp/dbget-bin/www_bget?ko01004 KEGG_Gene ecj:JW0483 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0483 KEGG_Gene eco:b0494 http://www.genome.jp/dbget-bin/www_bget?eco:b0494 KEGG_Orthology KO:K10804 http://www.genome.jp/dbget-bin/www_bget?KO:K10804 KEGG_Pathway ko01040 http://www.genome.jp/kegg-bin/show_pathway?ko01040 OMA PPNYGPD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PPNYGPD PDB 1IVN http://www.ebi.ac.uk/pdbe-srv/view/entry/1IVN PDB 1J00 http://www.ebi.ac.uk/pdbe-srv/view/entry/1J00 PDB 1JRL http://www.ebi.ac.uk/pdbe-srv/view/entry/1JRL PDB 1U8U http://www.ebi.ac.uk/pdbe-srv/view/entry/1U8U PDB 1V2G http://www.ebi.ac.uk/pdbe-srv/view/entry/1V2G PDBsum 1IVN http://www.ebi.ac.uk/pdbsum/1IVN PDBsum 1J00 http://www.ebi.ac.uk/pdbsum/1J00 PDBsum 1JRL http://www.ebi.ac.uk/pdbsum/1JRL PDBsum 1U8U http://www.ebi.ac.uk/pdbsum/1U8U PDBsum 1V2G http://www.ebi.ac.uk/pdbsum/1V2G PROSITE PS01098 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01098 PSORT swissprot:TESA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TESA_ECOLI PSORT-B swissprot:TESA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TESA_ECOLI PSORT2 swissprot:TESA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TESA_ECOLI Pfam PF13472 http://pfam.xfam.org/family/PF13472 Phobius swissprot:TESA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TESA_ECOLI PhylomeDB P0ADA1 http://phylomedb.org/?seqid=P0ADA1 ProteinModelPortal P0ADA1 http://www.proteinmodelportal.org/query/uniprot/P0ADA1 PubMed 12842470 http://www.ncbi.nlm.nih.gov/pubmed/12842470 PubMed 15697222 http://www.ncbi.nlm.nih.gov/pubmed/15697222 PubMed 16515533 http://www.ncbi.nlm.nih.gov/pubmed/16515533 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1864840 http://www.ncbi.nlm.nih.gov/pubmed/1864840 PubMed 8098033 http://www.ncbi.nlm.nih.gov/pubmed/8098033 PubMed 8432696 http://www.ncbi.nlm.nih.gov/pubmed/8432696 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415027 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415027 SMR P0ADA1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADA1 STRING 511145.b0494 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0494&targetmode=cogs STRING COG2755 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2755&targetmode=cogs SUPFAM SSF52266 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52266 SWISS-2DPAGE P0ADA1 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0ADA1 UniProtKB TESA_ECOLI http://www.uniprot.org/uniprot/TESA_ECOLI UniProtKB-AC P0ADA1 http://www.uniprot.org/uniprot/P0ADA1 charge swissprot:TESA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TESA_ECOLI eggNOG COG2755 http://eggnogapi.embl.de/nog_data/html/tree/COG2755 eggNOG ENOG4108UJV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UJV epestfind swissprot:TESA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TESA_ECOLI garnier swissprot:TESA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TESA_ECOLI helixturnhelix swissprot:TESA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TESA_ECOLI hmoment swissprot:TESA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TESA_ECOLI iep swissprot:TESA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TESA_ECOLI inforesidue swissprot:TESA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TESA_ECOLI octanol swissprot:TESA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TESA_ECOLI pepcoil swissprot:TESA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TESA_ECOLI pepdigest swissprot:TESA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TESA_ECOLI pepinfo swissprot:TESA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TESA_ECOLI pepnet swissprot:TESA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TESA_ECOLI pepstats swissprot:TESA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TESA_ECOLI pepwheel swissprot:TESA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TESA_ECOLI pepwindow swissprot:TESA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TESA_ECOLI sigcleave swissprot:TESA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TESA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260012 9 # COFACTOR YCAL_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000305}; Note=Binds 1 zinc ion per subunit. {ECO 0000305}; # EcoGene EG13133 ycaL # GO_function GO:0004222 metalloendopeptidase activity; IEA:InterPro. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0043167 ion binding # IntAct P43674 2 # InterPro IPR001915 Peptidase_M48 # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # Organism YCAL_ECOLI Escherichia coli (strain K12) # PATRIC 32117031 VBIEscCol129921_0940 # PIR D64830 D64830 # Pfam PF01435 Peptidase_M48 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCAL_ECOLI Uncharacterized metalloprotease YcaL # RefSeq NP_415429 NC_000913.3 # RefSeq WP_001350496 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA81515.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the peptidase M48B family. {ECO 0000305}. # eggNOG COG0501 LUCA # eggNOG ENOG4108K0D Bacteria BLAST swissprot:YCAL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCAL_ECOLI BioCyc ECOL316407:JW0892-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0892-MONOMER BioCyc EcoCyc:G6470-MONOMER http://biocyc.org/getid?id=EcoCyc:G6470-MONOMER COG COG0501 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0501 DIP DIP-11467N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11467N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.24.- http://www.genome.jp/dbget-bin/www_bget?EC:3.4.24.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U31523 http://www.ebi.ac.uk/ena/data/view/U31523 EMBL X82933 http://www.ebi.ac.uk/ena/data/view/X82933 ENZYME 3.4.24.- http://enzyme.expasy.org/EC/3.4.24.- EchoBASE EB2932 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2932 EcoGene EG13133 http://www.ecogene.org/geneInfo.php?eg_id=EG13133 EnsemblBacteria AAC73995 http://www.ensemblgenomes.org/id/AAC73995 EnsemblBacteria AAC73995 http://www.ensemblgenomes.org/id/AAC73995 EnsemblBacteria BAA35644 http://www.ensemblgenomes.org/id/BAA35644 EnsemblBacteria BAA35644 http://www.ensemblgenomes.org/id/BAA35644 EnsemblBacteria BAA35644 http://www.ensemblgenomes.org/id/BAA35644 EnsemblBacteria b0909 http://www.ensemblgenomes.org/id/b0909 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004222 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004222 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GeneID 945534 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945534 HOGENOM HOG000264551 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000264551&db=HOGENOM6 InParanoid P43674 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P43674 IntAct P43674 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P43674* IntEnz 3.4.24 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.24 InterPro IPR001915 http://www.ebi.ac.uk/interpro/entry/IPR001915 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW0892 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0892 KEGG_Gene eco:b0909 http://www.genome.jp/dbget-bin/www_bget?eco:b0909 KEGG_Orthology KO:K07387 http://www.genome.jp/dbget-bin/www_bget?KO:K07387 OMA GHDSATM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GHDSATM PSORT swissprot:YCAL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCAL_ECOLI PSORT-B swissprot:YCAL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCAL_ECOLI PSORT2 swissprot:YCAL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCAL_ECOLI Pfam PF01435 http://pfam.xfam.org/family/PF01435 Phobius swissprot:YCAL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCAL_ECOLI PhylomeDB P43674 http://phylomedb.org/?seqid=P43674 ProteinModelPortal P43674 http://www.proteinmodelportal.org/query/uniprot/P43674 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7836281 http://www.ncbi.nlm.nih.gov/pubmed/7836281 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415429 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415429 RefSeq WP_001350496 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001350496 SMR P43674 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P43674 STRING 511145.b0909 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0909&targetmode=cogs STRING COG0501 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0501&targetmode=cogs UniProtKB YCAL_ECOLI http://www.uniprot.org/uniprot/YCAL_ECOLI UniProtKB-AC P43674 http://www.uniprot.org/uniprot/P43674 charge swissprot:YCAL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCAL_ECOLI eggNOG COG0501 http://eggnogapi.embl.de/nog_data/html/tree/COG0501 eggNOG ENOG4108K0D http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108K0D epestfind swissprot:YCAL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCAL_ECOLI garnier swissprot:YCAL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCAL_ECOLI helixturnhelix swissprot:YCAL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCAL_ECOLI hmoment swissprot:YCAL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCAL_ECOLI iep swissprot:YCAL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCAL_ECOLI inforesidue swissprot:YCAL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCAL_ECOLI octanol swissprot:YCAL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCAL_ECOLI pepcoil swissprot:YCAL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCAL_ECOLI pepdigest swissprot:YCAL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCAL_ECOLI pepinfo swissprot:YCAL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCAL_ECOLI pepnet swissprot:YCAL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCAL_ECOLI pepstats swissprot:YCAL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCAL_ECOLI pepwheel swissprot:YCAL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCAL_ECOLI pepwindow swissprot:YCAL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCAL_ECOLI sigcleave swissprot:YCAL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCAL_ECOLI ## Database ID URL or Descriptions # EcoGene EG13392 yeeY # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; ISS:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR005119 LysR_subst-bd # InterPro IPR011991 WHTH_DNA-bd_dom # Organism YEEY_ECOLI Escherichia coli (strain K12) # PATRIC 32119365 VBIEscCol129921_2092 # PIR F64966 F64966 # PROSITE PS50931 HTH_LYSR # Pfam PF00126 HTH_1 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEEY_ECOLI Uncharacterized HTH-type transcriptional regulator YeeY # RefSeq NP_416519 NC_000913.3 # RefSeq WP_000803351 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lysR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00253}. # SUPFAM SSF46785 SSF46785 # eggNOG ENOG4105EQ1 Bacteria # eggNOG ENOG410XP36 LUCA BLAST swissprot:YEEY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEEY_ECOLI BioCyc ECOL316407:JW5834-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5834-MONOMER BioCyc EcoCyc:G7088-MONOMER http://biocyc.org/getid?id=EcoCyc:G7088-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3173 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3173 EcoGene EG13392 http://www.ecogene.org/geneInfo.php?eg_id=EG13392 EnsemblBacteria AAC75076 http://www.ensemblgenomes.org/id/AAC75076 EnsemblBacteria AAC75076 http://www.ensemblgenomes.org/id/AAC75076 EnsemblBacteria BAA15848 http://www.ensemblgenomes.org/id/BAA15848 EnsemblBacteria BAA15848 http://www.ensemblgenomes.org/id/BAA15848 EnsemblBacteria BAA15848 http://www.ensemblgenomes.org/id/BAA15848 EnsemblBacteria b2015 http://www.ensemblgenomes.org/id/b2015 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 946532 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946532 HOGENOM HOG000181312 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000181312&db=HOGENOM6 InParanoid P76369 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76369 InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW5834 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5834 KEGG_Gene eco:b2015 http://www.genome.jp/dbget-bin/www_bget?eco:b2015 OMA QIRGLGC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QIRGLGC PROSITE PS50931 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50931 PSORT swissprot:YEEY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEEY_ECOLI PSORT-B swissprot:YEEY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEEY_ECOLI PSORT2 swissprot:YEEY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEEY_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:YEEY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEEY_ECOLI PhylomeDB P76369 http://phylomedb.org/?seqid=P76369 ProteinModelPortal P76369 http://www.proteinmodelportal.org/query/uniprot/P76369 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416519 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416519 RefSeq WP_000803351 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000803351 SMR P76369 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76369 STRING 511145.b2015 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2015&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB YEEY_ECOLI http://www.uniprot.org/uniprot/YEEY_ECOLI UniProtKB-AC P76369 http://www.uniprot.org/uniprot/P76369 charge swissprot:YEEY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEEY_ECOLI eggNOG ENOG4105EQ1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EQ1 eggNOG ENOG410XP36 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XP36 epestfind swissprot:YEEY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEEY_ECOLI garnier swissprot:YEEY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEEY_ECOLI helixturnhelix swissprot:YEEY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEEY_ECOLI hmoment swissprot:YEEY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEEY_ECOLI iep swissprot:YEEY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEEY_ECOLI inforesidue swissprot:YEEY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEEY_ECOLI octanol swissprot:YEEY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEEY_ECOLI pepcoil swissprot:YEEY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEEY_ECOLI pepdigest swissprot:YEEY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEEY_ECOLI pepinfo swissprot:YEEY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEEY_ECOLI pepnet swissprot:YEEY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEEY_ECOLI pepstats swissprot:YEEY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEEY_ECOLI pepwheel swissprot:YEEY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEEY_ECOLI pepwindow swissprot:YEEY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEEY_ECOLI sigcleave swissprot:YEEY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEEY_ECOLI ## Database ID URL or Descriptions # EcoGene EG12512 ytfL # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0016614 oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro. # GO_function GO:0050660 flavin adenine dinucleotide binding; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # Gene3D 3.30.465.10 -; 1. # InterPro IPR000644 CBS_dom # InterPro IPR002550 DUF21 # InterPro IPR005170 Transptr-assoc_dom # InterPro IPR016166 FAD-bd_2 # InterPro IPR016169 CO_DH_flavot_FAD-bd_sub2 # Organism YTFL_ECOLI Escherichia coli (strain K12) # PATRIC 32124011 VBIEscCol129921_4350 # PIR S56443 S56443 # PROSITE PS51371 CBS; 2 # Pfam PF00571 CBS # Pfam PF01595 DUF21 # Pfam PF03471 CorC_HlyC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YTFL_ECOLI UPF0053 inner membrane protein YtfL # RefSeq NP_418639 NC_000913.3 # RefSeq WP_000935036 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0053 family. {ECO 0000305}. # SIMILARITY Contains 1 DUF21 domain. {ECO 0000305}. # SIMILARITY Contains 2 CBS domains. {ECO:0000255|PROSITE- ProRule PRU00703}. # SMART SM01091 CorC_HlyC # SUBCELLULAR LOCATION YTFL_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF56176 SSF56176 # eggNOG COG1253 LUCA # eggNOG ENOG4105C37 Bacteria BLAST swissprot:YTFL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YTFL_ECOLI BioCyc ECOL316407:JW4177-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4177-MONOMER BioCyc EcoCyc:G7873-MONOMER http://biocyc.org/getid?id=EcoCyc:G7873-MONOMER DIP DIP-48233N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48233N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2405 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2405 EcoGene EG12512 http://www.ecogene.org/geneInfo.php?eg_id=EG12512 EnsemblBacteria AAC77175 http://www.ensemblgenomes.org/id/AAC77175 EnsemblBacteria AAC77175 http://www.ensemblgenomes.org/id/AAC77175 EnsemblBacteria BAE78219 http://www.ensemblgenomes.org/id/BAE78219 EnsemblBacteria BAE78219 http://www.ensemblgenomes.org/id/BAE78219 EnsemblBacteria BAE78219 http://www.ensemblgenomes.org/id/BAE78219 EnsemblBacteria b4218 http://www.ensemblgenomes.org/id/b4218 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0016614 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016614 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.30.465.10 http://www.cathdb.info/version/latest/superfamily/3.30.465.10 GeneID 948735 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948735 HOGENOM HOG000062295 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000062295&db=HOGENOM6 InParanoid P0AE45 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AE45 InterPro IPR000644 http://www.ebi.ac.uk/interpro/entry/IPR000644 InterPro IPR002550 http://www.ebi.ac.uk/interpro/entry/IPR002550 InterPro IPR005170 http://www.ebi.ac.uk/interpro/entry/IPR005170 InterPro IPR016166 http://www.ebi.ac.uk/interpro/entry/IPR016166 InterPro IPR016169 http://www.ebi.ac.uk/interpro/entry/IPR016169 KEGG_Gene ecj:JW4177 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4177 KEGG_Gene eco:b4218 http://www.genome.jp/dbget-bin/www_bget?eco:b4218 OMA QPHSKFL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QPHSKFL PROSITE PS51371 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51371 PSORT swissprot:YTFL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YTFL_ECOLI PSORT-B swissprot:YTFL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YTFL_ECOLI PSORT2 swissprot:YTFL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YTFL_ECOLI Pfam PF00571 http://pfam.xfam.org/family/PF00571 Pfam PF01595 http://pfam.xfam.org/family/PF01595 Pfam PF03471 http://pfam.xfam.org/family/PF03471 Phobius swissprot:YTFL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YTFL_ECOLI PhylomeDB P0AE45 http://phylomedb.org/?seqid=P0AE45 ProteinModelPortal P0AE45 http://www.proteinmodelportal.org/query/uniprot/P0AE45 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418639 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418639 RefSeq WP_000935036 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000935036 SMART SM01091 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01091 SMR P0AE45 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AE45 STRING 511145.b4218 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4218&targetmode=cogs SUPFAM SSF56176 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56176 UniProtKB YTFL_ECOLI http://www.uniprot.org/uniprot/YTFL_ECOLI UniProtKB-AC P0AE45 http://www.uniprot.org/uniprot/P0AE45 charge swissprot:YTFL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YTFL_ECOLI eggNOG COG1253 http://eggnogapi.embl.de/nog_data/html/tree/COG1253 eggNOG ENOG4105C37 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C37 epestfind swissprot:YTFL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YTFL_ECOLI garnier swissprot:YTFL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YTFL_ECOLI helixturnhelix swissprot:YTFL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YTFL_ECOLI hmoment swissprot:YTFL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YTFL_ECOLI iep swissprot:YTFL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YTFL_ECOLI inforesidue swissprot:YTFL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YTFL_ECOLI octanol swissprot:YTFL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YTFL_ECOLI pepcoil swissprot:YTFL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YTFL_ECOLI pepdigest swissprot:YTFL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YTFL_ECOLI pepinfo swissprot:YTFL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YTFL_ECOLI pepnet swissprot:YTFL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YTFL_ECOLI pepstats swissprot:YTFL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YTFL_ECOLI pepwheel swissprot:YTFL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YTFL_ECOLI pepwindow swissprot:YTFL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YTFL_ECOLI sigcleave swissprot:YTFL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YTFL_ECOLI ## Database ID URL or Descriptions # AltName MANC_ECOLI GDP-mannose pyrophosphorylase # BioGrid 4263312 176 # CATALYTIC ACTIVITY MANC_ECOLI GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose. # EcoGene EG10161 manC # FUNCTION MANC_ECOLI Involved in the biosynthesis of the capsular polysaccharide colanic acid. # GO_function GO:0004475 mannose-1-phosphate guanylyltransferase activity; IDA:EcoCyc. # GO_function GO:0005525 GTP binding; IEA:UniProtKB-KW. # GO_process GO:0006972 hyperosmotic response; IEP:EcoCyc. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0009242 colanic acid biosynthetic process; IMP:EcoCyc. # GO_process GO:0009298 GDP-mannose biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 2.60.120.10 -; 1. # Gene3D 3.90.550.10 -; 1. # IntAct P24174 5 # InterPro IPR001538 Man6P_isomerase-2_C # InterPro IPR005835 NTP_transferase_dom # InterPro IPR006375 Man1P_GuaTrfase/Man6P_Isoase # InterPro IPR011051 RmlC_Cupin # InterPro IPR014710 RmlC-like_jellyroll # InterPro IPR029044 Nucleotide-diphossugar_trans # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00051 Fructose and mannose metabolism # KEGG_Pathway ko00520 Amino sugar and nucleotide sugar metabolism # Organism MANC_ECOLI Escherichia coli (strain K12) # PATHWAY Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route) step 1/1. # PATRIC 32119431 VBIEscCol129921_2126 # PIR H64970 H64970 # Pfam PF00483 NTP_transferase # Pfam PF01050 MannoseP_isomer # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MANC_ECOLI Mannose-1-phosphate guanylyltransferase # RefSeq NP_416553 NC_000913.3 # RefSeq WP_000079274 NZ_LN832404.1 # SIMILARITY Belongs to the mannose-6-phosphate isomerase type 2 family. {ECO 0000305}. # SUPFAM SSF51182 SSF51182 # SUPFAM SSF53448 SSF53448 # TIGRFAMs TIGR01479 GMP_PMI # UniPathway UPA00126 UER00930 # eggNOG COG0662 LUCA # eggNOG COG0836 LUCA # eggNOG ENOG4105CJT Bacteria BLAST swissprot:MANC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MANC_ECOLI BioCyc ECOL316407:JW2034-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2034-MONOMER BioCyc EcoCyc:MANNPGUANYLTRANGDP-MONOMER http://biocyc.org/getid?id=EcoCyc:MANNPGUANYLTRANGDP-MONOMER BioCyc MetaCyc:MANNPGUANYLTRANGDP-MONOMER http://biocyc.org/getid?id=MetaCyc:MANNPGUANYLTRANGDP-MONOMER COG COG0662 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0662 COG COG0836 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0836 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.7.13 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.13 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M77127 http://www.ebi.ac.uk/ena/data/view/M77127 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U38473 http://www.ebi.ac.uk/ena/data/view/U38473 ENZYME 2.7.7.13 http://enzyme.expasy.org/EC/2.7.7.13 EchoBASE EB0159 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0159 EcoGene EG10161 http://www.ecogene.org/geneInfo.php?eg_id=EG10161 EnsemblBacteria AAC75110 http://www.ensemblgenomes.org/id/AAC75110 EnsemblBacteria AAC75110 http://www.ensemblgenomes.org/id/AAC75110 EnsemblBacteria BAA15905 http://www.ensemblgenomes.org/id/BAA15905 EnsemblBacteria BAA15905 http://www.ensemblgenomes.org/id/BAA15905 EnsemblBacteria BAA15905 http://www.ensemblgenomes.org/id/BAA15905 EnsemblBacteria b2049 http://www.ensemblgenomes.org/id/b2049 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004475 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004475 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_process GO:0006972 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006972 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GO_process GO:0009242 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009242 GO_process GO:0009298 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009298 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 2.60.120.10 http://www.cathdb.info/version/latest/superfamily/2.60.120.10 Gene3D 3.90.550.10 http://www.cathdb.info/version/latest/superfamily/3.90.550.10 GeneID 946580 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946580 HOGENOM HOG000153549 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000153549&db=HOGENOM6 InParanoid P24174 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P24174 IntAct P24174 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P24174* IntEnz 2.7.7.13 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.13 InterPro IPR001538 http://www.ebi.ac.uk/interpro/entry/IPR001538 InterPro IPR005835 http://www.ebi.ac.uk/interpro/entry/IPR005835 InterPro IPR006375 http://www.ebi.ac.uk/interpro/entry/IPR006375 InterPro IPR011051 http://www.ebi.ac.uk/interpro/entry/IPR011051 InterPro IPR014710 http://www.ebi.ac.uk/interpro/entry/IPR014710 InterPro IPR029044 http://www.ebi.ac.uk/interpro/entry/IPR029044 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2034 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2034 KEGG_Gene eco:b2049 http://www.genome.jp/dbget-bin/www_bget?eco:b2049 KEGG_Orthology KO:K00971 http://www.genome.jp/dbget-bin/www_bget?KO:K00971 KEGG_Pathway ko00051 http://www.genome.jp/kegg-bin/show_pathway?ko00051 KEGG_Pathway ko00520 http://www.genome.jp/kegg-bin/show_pathway?ko00520 KEGG_Reaction rn:R00885 http://www.genome.jp/dbget-bin/www_bget?rn:R00885 OMA ETQIGEY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ETQIGEY PSORT swissprot:MANC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MANC_ECOLI PSORT-B swissprot:MANC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MANC_ECOLI PSORT2 swissprot:MANC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MANC_ECOLI Pfam PF00483 http://pfam.xfam.org/family/PF00483 Pfam PF01050 http://pfam.xfam.org/family/PF01050 Phobius swissprot:MANC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MANC_ECOLI PhylomeDB P24174 http://phylomedb.org/?seqid=P24174 ProteinModelPortal P24174 http://www.proteinmodelportal.org/query/uniprot/P24174 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7815923 http://www.ncbi.nlm.nih.gov/pubmed/7815923 PubMed 8759852 http://www.ncbi.nlm.nih.gov/pubmed/8759852 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416553 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416553 RefSeq WP_000079274 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000079274 SMR P24174 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P24174 STRING 511145.b2049 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2049&targetmode=cogs STRING COG0662 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0662&targetmode=cogs STRING COG0836 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0836&targetmode=cogs SUPFAM SSF51182 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51182 SUPFAM SSF53448 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53448 TIGRFAMs TIGR01479 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01479 UniProtKB MANC_ECOLI http://www.uniprot.org/uniprot/MANC_ECOLI UniProtKB-AC P24174 http://www.uniprot.org/uniprot/P24174 charge swissprot:MANC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MANC_ECOLI eggNOG COG0662 http://eggnogapi.embl.de/nog_data/html/tree/COG0662 eggNOG COG0836 http://eggnogapi.embl.de/nog_data/html/tree/COG0836 eggNOG ENOG4105CJT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CJT epestfind swissprot:MANC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MANC_ECOLI garnier swissprot:MANC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MANC_ECOLI helixturnhelix swissprot:MANC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MANC_ECOLI hmoment swissprot:MANC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MANC_ECOLI iep swissprot:MANC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MANC_ECOLI inforesidue swissprot:MANC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MANC_ECOLI octanol swissprot:MANC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MANC_ECOLI pepcoil swissprot:MANC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MANC_ECOLI pepdigest swissprot:MANC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MANC_ECOLI pepinfo swissprot:MANC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MANC_ECOLI pepnet swissprot:MANC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MANC_ECOLI pepstats swissprot:MANC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MANC_ECOLI pepwheel swissprot:MANC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MANC_ECOLI pepwindow swissprot:MANC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MANC_ECOLI sigcleave swissprot:MANC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MANC_ECOLI ## Database ID URL or Descriptions # BioGrid 4260902 16 # EcoGene EG13532 ybdM # INTERACTION YBDM_ECOLI P0AFW4 rnk; NbExp=5; IntAct=EBI-1118992, EBI-553769; # IntAct P77174 32 # InterPro IPR003115 ParB/Sulfiredoxin_dom # Organism YBDM_ECOLI Escherichia coli (strain K12) # PATRIC 32116380 VBIEscCol129921_0630 # PIR G64793 G64793 # Pfam PF02195 ParBc # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBDM_ECOLI Uncharacterized protein YbdM # RefSeq NP_415134 NC_000913.3 # SMART SM00470 ParB # SUPFAM SSF110849 SSF110849 # eggNOG COG1475 LUCA # eggNOG ENOG4105GTN Bacteria BLAST swissprot:YBDM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBDM_ECOLI BioCyc ECOL316407:JW0594-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0594-MONOMER BioCyc EcoCyc:G6330-MONOMER http://biocyc.org/getid?id=EcoCyc:G6330-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB3303 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3303 EcoGene EG13532 http://www.ecogene.org/geneInfo.php?eg_id=EG13532 EnsemblBacteria AAC73702 http://www.ensemblgenomes.org/id/AAC73702 EnsemblBacteria AAC73702 http://www.ensemblgenomes.org/id/AAC73702 EnsemblBacteria BAA35231 http://www.ensemblgenomes.org/id/BAA35231 EnsemblBacteria BAA35231 http://www.ensemblgenomes.org/id/BAA35231 EnsemblBacteria BAA35231 http://www.ensemblgenomes.org/id/BAA35231 EnsemblBacteria b0601 http://www.ensemblgenomes.org/id/b0601 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945206 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945206 HOGENOM HOG000005607 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000005607&db=HOGENOM6 InParanoid P77174 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77174 IntAct P77174 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77174* InterPro IPR003115 http://www.ebi.ac.uk/interpro/entry/IPR003115 KEGG_Gene ecj:JW0594 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0594 KEGG_Gene eco:b0601 http://www.genome.jp/dbget-bin/www_bget?eco:b0601 OMA AEEYEIV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AEEYEIV PSORT swissprot:YBDM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBDM_ECOLI PSORT-B swissprot:YBDM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBDM_ECOLI PSORT2 swissprot:YBDM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBDM_ECOLI Pfam PF02195 http://pfam.xfam.org/family/PF02195 Phobius swissprot:YBDM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBDM_ECOLI PhylomeDB P77174 http://phylomedb.org/?seqid=P77174 ProteinModelPortal P77174 http://www.proteinmodelportal.org/query/uniprot/P77174 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415134 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415134 SMART SM00470 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00470 SMR P77174 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77174 STRING 511145.b0601 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0601&targetmode=cogs SUPFAM SSF110849 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF110849 UniProtKB YBDM_ECOLI http://www.uniprot.org/uniprot/YBDM_ECOLI UniProtKB-AC P77174 http://www.uniprot.org/uniprot/P77174 charge swissprot:YBDM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBDM_ECOLI eggNOG COG1475 http://eggnogapi.embl.de/nog_data/html/tree/COG1475 eggNOG ENOG4105GTN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105GTN epestfind swissprot:YBDM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBDM_ECOLI garnier swissprot:YBDM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBDM_ECOLI helixturnhelix swissprot:YBDM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBDM_ECOLI hmoment swissprot:YBDM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBDM_ECOLI iep swissprot:YBDM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBDM_ECOLI inforesidue swissprot:YBDM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBDM_ECOLI octanol swissprot:YBDM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBDM_ECOLI pepcoil swissprot:YBDM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBDM_ECOLI pepdigest swissprot:YBDM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBDM_ECOLI pepinfo swissprot:YBDM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBDM_ECOLI pepnet swissprot:YBDM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBDM_ECOLI pepstats swissprot:YBDM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBDM_ECOLI pepwheel swissprot:YBDM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBDM_ECOLI pepwindow swissprot:YBDM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBDM_ECOLI sigcleave swissprot:YBDM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBDM_ECOLI ## Database ID URL or Descriptions # AltName Queuosine biosynthesis protein QueG {ECO:0000255|HAMAP-Rule MF_00916} # BioGrid 4262703 4 # CATALYTIC ACTIVITY Queuosine(34) in tRNA + acceptor + H(2)O = epoxyqueuosine(34) in tRNA + reduced acceptor. {ECO:0000255|HAMAP- Rule MF_00916}. # DISRUPTION PHENOTYPE RNA from mutants accumulates epoxyqueuosine and lacks queuosine. {ECO:0000269|PubMed 21502530}. # EcoGene EG12481 queG # FUNCTION QUEG_ECOLI Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). {ECO 0000255|HAMAP-Rule MF_00916}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GO_function GO:0052693 epoxyqueuosine reductase activity; IMP:EcoCyc. # GO_process GO:0008033 tRNA processing; IEA:UniProtKB-HAMAP. # GO_process GO:0008616 queuosine biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # HAMAP MF_00916 QueG # IntAct P39288 2 # InterPro IPR004453 QueG # InterPro IPR009051 Helical_ferredxn # InterPro IPR013542 DUF1730 # InterPro IPR017896 4Fe4S_Fe-S-bd # InterPro IPR017900 4Fe4S_Fe_S_CS # Organism QUEG_ECOLI Escherichia coli (strain K12) # PATHWAY QUEG_ECOLI tRNA modification; tRNA-queuosine biosynthesis. {ECO 0000255|HAMAP-Rule MF_00916, ECO 0000269|PubMed 21502530}. # PATRIC 32123905 VBIEscCol129921_4297 # PIR S56391 S56391 # PROSITE PS00198 4FE4S_FER_1 # PROSITE PS51379 4FE4S_FER_2 # Pfam PF08331 DUF1730 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Epoxyqueuosine reductase {ECO:0000255|HAMAP-Rule MF_00916} # RefSeq NP_418587 NC_000913.3 # RefSeq WP_001294219 NZ_LN832404.1 # SIMILARITY Belongs to the QueG family. {ECO:0000255|HAMAP- Rule MF_00916}. # SIMILARITY Contains 1 4Fe-4S ferredoxin-type domain. {ECO:0000255|HAMAP-Rule MF_00916}. # SUBCELLULAR LOCATION QUEG_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00916}. # SUPFAM SSF46548 SSF46548 # TIGRFAMs TIGR00276 TIGR00276 # eggNOG COG1600 LUCA # eggNOG ENOG4105EH2 Bacteria BLAST swissprot:QUEG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:QUEG_ECOLI BioCyc ECOL316407:JW4124-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4124-MONOMER BioCyc EcoCyc:G7843-MONOMER http://biocyc.org/getid?id=EcoCyc:G7843-MONOMER BioCyc MetaCyc:G7843-MONOMER http://biocyc.org/getid?id=MetaCyc:G7843-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.1018636108 http://dx.doi.org/10.1073/pnas.1018636108 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.17.99.6 {ECO:0000255|HAMAP-Rule:MF_00916} http://www.genome.jp/dbget-bin/www_bget?EC:1.17.99.6 {ECO:0000255|HAMAP-Rule:MF_00916} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 1.17.99.6 {ECO:0000255|HAMAP-Rule:MF_00916} http://enzyme.expasy.org/EC/1.17.99.6 {ECO:0000255|HAMAP-Rule:MF_00916} EchoBASE EB2374 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2374 EcoGene EG12481 http://www.ecogene.org/geneInfo.php?eg_id=EG12481 EnsemblBacteria AAC77123 http://www.ensemblgenomes.org/id/AAC77123 EnsemblBacteria AAC77123 http://www.ensemblgenomes.org/id/AAC77123 EnsemblBacteria BAE78167 http://www.ensemblgenomes.org/id/BAE78167 EnsemblBacteria BAE78167 http://www.ensemblgenomes.org/id/BAE78167 EnsemblBacteria BAE78167 http://www.ensemblgenomes.org/id/BAE78167 EnsemblBacteria b4166 http://www.ensemblgenomes.org/id/b4166 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_function GO:0052693 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052693 GO_process GO:0008033 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008033 GO_process GO:0008616 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008616 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 948686 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948686 HAMAP MF_00916 http://hamap.expasy.org/unirule/MF_00916 HOGENOM HOG000272643 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000272643&db=HOGENOM6 InParanoid P39288 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39288 IntAct P39288 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39288* IntEnz 1.17.99.6 {ECO:0000255|HAMAP-Rule:MF_00916} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.17.99.6 {ECO:0000255|HAMAP-Rule:MF_00916} InterPro IPR004453 http://www.ebi.ac.uk/interpro/entry/IPR004453 InterPro IPR009051 http://www.ebi.ac.uk/interpro/entry/IPR009051 InterPro IPR013542 http://www.ebi.ac.uk/interpro/entry/IPR013542 InterPro IPR017896 http://www.ebi.ac.uk/interpro/entry/IPR017896 InterPro IPR017900 http://www.ebi.ac.uk/interpro/entry/IPR017900 KEGG_Gene ecj:JW4124 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4124 KEGG_Gene eco:b4166 http://www.genome.jp/dbget-bin/www_bget?eco:b4166 OMA ICDTDLS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ICDTDLS PROSITE PS00198 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00198 PROSITE PS51379 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51379 PSORT swissprot:QUEG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:QUEG_ECOLI PSORT-B swissprot:QUEG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:QUEG_ECOLI PSORT2 swissprot:QUEG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:QUEG_ECOLI Pfam PF08331 http://pfam.xfam.org/family/PF08331 Phobius swissprot:QUEG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:QUEG_ECOLI PhylomeDB P39288 http://phylomedb.org/?seqid=P39288 ProteinModelPortal P39288 http://www.proteinmodelportal.org/query/uniprot/P39288 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21502530 http://www.ncbi.nlm.nih.gov/pubmed/21502530 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418587 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418587 RefSeq WP_001294219 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001294219 STRING 511145.b4166 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4166&targetmode=cogs SUPFAM SSF46548 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46548 TIGRFAMs TIGR00276 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00276 UniProtKB QUEG_ECOLI http://www.uniprot.org/uniprot/QUEG_ECOLI UniProtKB-AC P39288 http://www.uniprot.org/uniprot/P39288 charge swissprot:QUEG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:QUEG_ECOLI eggNOG COG1600 http://eggnogapi.embl.de/nog_data/html/tree/COG1600 eggNOG ENOG4105EH2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EH2 epestfind swissprot:QUEG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:QUEG_ECOLI garnier swissprot:QUEG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:QUEG_ECOLI helixturnhelix swissprot:QUEG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:QUEG_ECOLI hmoment swissprot:QUEG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:QUEG_ECOLI iep swissprot:QUEG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:QUEG_ECOLI inforesidue swissprot:QUEG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:QUEG_ECOLI octanol swissprot:QUEG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:QUEG_ECOLI pepcoil swissprot:QUEG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:QUEG_ECOLI pepdigest swissprot:QUEG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:QUEG_ECOLI pepinfo swissprot:QUEG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:QUEG_ECOLI pepnet swissprot:QUEG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:QUEG_ECOLI pepstats swissprot:QUEG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:QUEG_ECOLI pepwheel swissprot:QUEG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:QUEG_ECOLI pepwindow swissprot:QUEG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:QUEG_ECOLI sigcleave swissprot:QUEG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:QUEG_ECOLI ## Database ID URL or Descriptions # EcoGene EG13414 csgC # FUNCTION CSGC_ECOLI Plays a role in the extracellular assembly of CsgA into thin aggregative fimbriae (Tafi) fibers. Assembly may also require CsgE. Tafi are thought to be assembled via an extracellular nucleation-precipitation (ENP) pathway, and possibly also via an intracellular non-CsgC-dependent pathway (By similarity). {ECO 0000250}. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GOslim_component GO:0005575 cellular_component # INDUCTION Under control of the CsgD transcription factor, part of the csgBAC/ymdA operon. {ECO:0000269|PubMed 17010156}. # InterPro IPR014491 Curli_production_prot_CsgC # KEGG_Brite ko02044 Secretion system # Organism CSGC_ECOLI Escherichia coli (strain K12) # PATRIC 32117323 VBIEscCol129921_1084 # PIR S70789 S70789 # PIRSF PIRSF018100 CsgC # Pfam PF10610 Tafi-CsgC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CSGC_ECOLI Curli assembly protein CsgC # RefSeq NP_415561 NC_000913.3 # RefSeq WP_001094300 NZ_LN832404.1 # SIMILARITY Belongs to the CsgC/AgfC family. {ECO 0000305}. # SUBCELLULAR LOCATION CSGC_ECOLI Periplasm {ECO 0000250}. # eggNOG ENOG4105RK8 Bacteria # eggNOG ENOG4111VMB LUCA BLAST swissprot:CSGC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CSGC_ECOLI BioCyc ECOL316407:JW1026-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1026-MONOMER BioCyc EcoCyc:G6548-MONOMER http://biocyc.org/getid?id=EcoCyc:G6548-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1995.mmi_18040661.x http://dx.doi.org/10.1111/j.1365-2958.1995.mmi_18040661.x DOI 10.1111/j.1365-2958.2006.05440.x http://dx.doi.org/10.1111/j.1365-2958.2006.05440.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X90754 http://www.ebi.ac.uk/ena/data/view/X90754 EchoBASE EB3190 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3190 EcoGene EG13414 http://www.ecogene.org/geneInfo.php?eg_id=EG13414 EnsemblBacteria AAC74127 http://www.ensemblgenomes.org/id/AAC74127 EnsemblBacteria AAC74127 http://www.ensemblgenomes.org/id/AAC74127 EnsemblBacteria BAA35833 http://www.ensemblgenomes.org/id/BAA35833 EnsemblBacteria BAA35833 http://www.ensemblgenomes.org/id/BAA35833 EnsemblBacteria BAA35833 http://www.ensemblgenomes.org/id/BAA35833 EnsemblBacteria b1043 http://www.ensemblgenomes.org/id/b1043 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GeneID 945623 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945623 HOGENOM HOG000118962 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118962&db=HOGENOM6 InterPro IPR014491 http://www.ebi.ac.uk/interpro/entry/IPR014491 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW1026 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1026 KEGG_Gene eco:b1043 http://www.genome.jp/dbget-bin/www_bget?eco:b1043 KEGG_Orthology KO:K04336 http://www.genome.jp/dbget-bin/www_bget?KO:K04336 OMA LSQQWPS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LSQQWPS PSORT swissprot:CSGC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CSGC_ECOLI PSORT-B swissprot:CSGC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CSGC_ECOLI PSORT2 swissprot:CSGC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CSGC_ECOLI Pfam PF10610 http://pfam.xfam.org/family/PF10610 Phobius swissprot:CSGC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CSGC_ECOLI ProteinModelPortal P52107 http://www.proteinmodelportal.org/query/uniprot/P52107 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17010156 http://www.ncbi.nlm.nih.gov/pubmed/17010156 PubMed 8817489 http://www.ncbi.nlm.nih.gov/pubmed/8817489 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415561 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415561 RefSeq WP_001094300 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001094300 SMR P52107 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P52107 STRING 511145.b1043 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1043&targetmode=cogs UniProtKB CSGC_ECOLI http://www.uniprot.org/uniprot/CSGC_ECOLI UniProtKB-AC P52107 http://www.uniprot.org/uniprot/P52107 charge swissprot:CSGC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CSGC_ECOLI eggNOG ENOG4105RK8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105RK8 eggNOG ENOG4111VMB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111VMB epestfind swissprot:CSGC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CSGC_ECOLI garnier swissprot:CSGC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CSGC_ECOLI helixturnhelix swissprot:CSGC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CSGC_ECOLI hmoment swissprot:CSGC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CSGC_ECOLI iep swissprot:CSGC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CSGC_ECOLI inforesidue swissprot:CSGC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CSGC_ECOLI octanol swissprot:CSGC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CSGC_ECOLI pepcoil swissprot:CSGC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CSGC_ECOLI pepdigest swissprot:CSGC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CSGC_ECOLI pepinfo swissprot:CSGC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CSGC_ECOLI pepnet swissprot:CSGC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CSGC_ECOLI pepstats swissprot:CSGC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CSGC_ECOLI pepwheel swissprot:CSGC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CSGC_ECOLI pepwindow swissprot:CSGC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CSGC_ECOLI sigcleave swissprot:CSGC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CSGC_ECOLI ## Database ID URL or Descriptions # BioGrid 4262576 2 # EcoGene EG11713 yidR # Gene3D 2.120.10.30 -; 2. # InterPro IPR011042 6-blade_b-propeller_TolB-like # InterPro IPR011659 PD40 # InterPro IPR022223 DUF3748 # Organism YIDR_ECOLI Escherichia coli (strain K12) # PATRIC 32122873 VBIEscCol129921_3812 # PIR B65171 B65171 # Pfam PF07676 PD40 # Pfam PF12566 DUF3748 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIDR_ECOLI Uncharacterized protein YidR # RefSeq NP_418144 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA62041.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAE77605.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # eggNOG ENOG4105D99 Bacteria # eggNOG ENOG410XQ17 LUCA BLAST swissprot:YIDR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIDR_ECOLI BioCyc ECOL316407:JW5860-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5860-MONOMER BioCyc EcoCyc:EG11713-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11713-MONOMER DIP DIP-12454N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12454N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1664 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1664 EcoGene EG11713 http://www.ecogene.org/geneInfo.php?eg_id=EG11713 EnsemblBacteria AAC76712 http://www.ensemblgenomes.org/id/AAC76712 EnsemblBacteria AAC76712 http://www.ensemblgenomes.org/id/AAC76712 EnsemblBacteria BAE77605 http://www.ensemblgenomes.org/id/BAE77605 EnsemblBacteria BAE77605 http://www.ensemblgenomes.org/id/BAE77605 EnsemblBacteria BAE77605 http://www.ensemblgenomes.org/id/BAE77605 EnsemblBacteria b3689 http://www.ensemblgenomes.org/id/b3689 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 2.120.10.30 http://www.cathdb.info/version/latest/superfamily/2.120.10.30 GeneID 948198 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948198 HOGENOM HOG000126359 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126359&db=HOGENOM6 InParanoid P31455 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31455 InterPro IPR011042 http://www.ebi.ac.uk/interpro/entry/IPR011042 InterPro IPR011659 http://www.ebi.ac.uk/interpro/entry/IPR011659 InterPro IPR022223 http://www.ebi.ac.uk/interpro/entry/IPR022223 KEGG_Gene ecj:JW5860 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5860 KEGG_Gene eco:b3689 http://www.genome.jp/dbget-bin/www_bget?eco:b3689 PSORT swissprot:YIDR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIDR_ECOLI PSORT-B swissprot:YIDR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIDR_ECOLI PSORT2 swissprot:YIDR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIDR_ECOLI Pfam PF07676 http://pfam.xfam.org/family/PF07676 Pfam PF12566 http://pfam.xfam.org/family/PF12566 Phobius swissprot:YIDR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIDR_ECOLI ProteinModelPortal P31455 http://www.proteinmodelportal.org/query/uniprot/P31455 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418144 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418144 STRING 511145.b3689 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3689&targetmode=cogs UniProtKB YIDR_ECOLI http://www.uniprot.org/uniprot/YIDR_ECOLI UniProtKB-AC P31455 http://www.uniprot.org/uniprot/P31455 charge swissprot:YIDR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIDR_ECOLI eggNOG ENOG4105D99 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D99 eggNOG ENOG410XQ17 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQ17 epestfind swissprot:YIDR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIDR_ECOLI garnier swissprot:YIDR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIDR_ECOLI helixturnhelix swissprot:YIDR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIDR_ECOLI hmoment swissprot:YIDR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIDR_ECOLI iep swissprot:YIDR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIDR_ECOLI inforesidue swissprot:YIDR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIDR_ECOLI octanol swissprot:YIDR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIDR_ECOLI pepcoil swissprot:YIDR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIDR_ECOLI pepdigest swissprot:YIDR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIDR_ECOLI pepinfo swissprot:YIDR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIDR_ECOLI pepnet swissprot:YIDR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIDR_ECOLI pepstats swissprot:YIDR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIDR_ECOLI pepwheel swissprot:YIDR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIDR_ECOLI pepwindow swissprot:YIDR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIDR_ECOLI sigcleave swissprot:YIDR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIDR_ECOLI ## Database ID URL or Descriptions # BioGrid 4260904 5 # CDD cd01713 PAPS_reductase # EcoGene EG13533 ybdN # GO_function GO:0003824 catalytic activity; IEA:InterPro. # GO_process GO:0008152 metabolic process; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.620 -; 1. # IntAct P77216 7 # InterPro IPR002500 PAPS_reduct # InterPro IPR014729 Rossmann-like_a/b/a_fold # InterPro IPR021845 DUF3440 # Organism YBDN_ECOLI Escherichia coli (strain K12) # PATRIC 32116382 VBIEscCol129921_0631 # PIR H64793 H64793 # Pfam PF01507 PAPS_reduct # Pfam PF11922 DUF3440; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBDN_ECOLI Uncharacterized protein YbdN # RefSeq NP_415135 NC_000913.3 # RefSeq WP_000029814 NZ_LN832404.1 # eggNOG COG3969 LUCA # eggNOG ENOG4105BZV Bacteria BLAST swissprot:YBDN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBDN_ECOLI BioCyc ECOL316407:JW0595-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0595-MONOMER BioCyc EcoCyc:G6331-MONOMER http://biocyc.org/getid?id=EcoCyc:G6331-MONOMER DIP DIP-11352N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11352N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB3304 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3304 EcoGene EG13533 http://www.ecogene.org/geneInfo.php?eg_id=EG13533 EnsemblBacteria AAC73703 http://www.ensemblgenomes.org/id/AAC73703 EnsemblBacteria AAC73703 http://www.ensemblgenomes.org/id/AAC73703 EnsemblBacteria BAA35232 http://www.ensemblgenomes.org/id/BAA35232 EnsemblBacteria BAA35232 http://www.ensemblgenomes.org/id/BAA35232 EnsemblBacteria BAA35232 http://www.ensemblgenomes.org/id/BAA35232 EnsemblBacteria b0602 http://www.ensemblgenomes.org/id/b0602 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003824 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003824 GO_process GO:0008152 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008152 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 GeneID 945205 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945205 HOGENOM HOG000005719 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000005719&db=HOGENOM6 InParanoid P77216 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77216 IntAct P77216 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77216* InterPro IPR002500 http://www.ebi.ac.uk/interpro/entry/IPR002500 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 InterPro IPR021845 http://www.ebi.ac.uk/interpro/entry/IPR021845 KEGG_Gene ecj:JW0595 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0595 KEGG_Gene eco:b0602 http://www.genome.jp/dbget-bin/www_bget?eco:b0602 MINT MINT-1293928 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1293928 OMA WQCWEPG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WQCWEPG PSORT swissprot:YBDN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBDN_ECOLI PSORT-B swissprot:YBDN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBDN_ECOLI PSORT2 swissprot:YBDN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBDN_ECOLI Pfam PF01507 http://pfam.xfam.org/family/PF01507 Pfam PF11922 http://pfam.xfam.org/family/PF11922 Phobius swissprot:YBDN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBDN_ECOLI PhylomeDB P77216 http://phylomedb.org/?seqid=P77216 ProteinModelPortal P77216 http://www.proteinmodelportal.org/query/uniprot/P77216 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415135 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415135 RefSeq WP_000029814 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000029814 STRING 511145.b0602 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0602&targetmode=cogs UniProtKB YBDN_ECOLI http://www.uniprot.org/uniprot/YBDN_ECOLI UniProtKB-AC P77216 http://www.uniprot.org/uniprot/P77216 charge swissprot:YBDN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBDN_ECOLI eggNOG COG3969 http://eggnogapi.embl.de/nog_data/html/tree/COG3969 eggNOG ENOG4105BZV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZV epestfind swissprot:YBDN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBDN_ECOLI garnier swissprot:YBDN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBDN_ECOLI helixturnhelix swissprot:YBDN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBDN_ECOLI hmoment swissprot:YBDN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBDN_ECOLI iep swissprot:YBDN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBDN_ECOLI inforesidue swissprot:YBDN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBDN_ECOLI octanol swissprot:YBDN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBDN_ECOLI pepcoil swissprot:YBDN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBDN_ECOLI pepdigest swissprot:YBDN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBDN_ECOLI pepinfo swissprot:YBDN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBDN_ECOLI pepnet swissprot:YBDN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBDN_ECOLI pepstats swissprot:YBDN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBDN_ECOLI pepwheel swissprot:YBDN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBDN_ECOLI pepwindow swissprot:YBDN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBDN_ECOLI sigcleave swissprot:YBDN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBDN_ECOLI ## Database ID URL or Descriptions # BioGrid 4259155 152 # CDD cd06174 MFS # EcoGene EG14019 yebQ # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0055085 transmembrane transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0055085 transmembrane transport # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # KEGG_Brite ko02000 Transporters # Organism YEBQ_ECOLI Escherichia coli (strain K12) # PATRIC 32118977 VBIEscCol129921_1906 # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEBQ_ECOLI Uncharacterized transporter YebQ # RefSeq NP_416342 NC_000913.3 # RefSeq WP_001127216 NZ_LN832404.1 # SIMILARITY Belongs to the major facilitator superfamily. TCR/Tet family. {ECO 0000305}. # SUBCELLULAR LOCATION YEBQ_ECOLI Cell inner membrane {ECO 0000305}; Multi- pass membrane protein {ECO 0000305}. # SUPFAM SSF103473 SSF103473; 2 # TCDB 2.A.1.3.17 the major facilitator superfamily (mfs) # eggNOG ENOG4105C0R Bacteria # eggNOG ENOG410XNN3 LUCA BLAST swissprot:YEBQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEBQ_ECOLI BioCyc ECOL316407:JW5299-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5299-MONOMER BioCyc EcoCyc:B1828-MONOMER http://biocyc.org/getid?id=EcoCyc:B1828-MONOMER COG COG0477 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0477 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3773 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3773 EcoGene EG14019 http://www.ecogene.org/geneInfo.php?eg_id=EG14019 EnsemblBacteria AAC74898 http://www.ensemblgenomes.org/id/AAC74898 EnsemblBacteria AAC74898 http://www.ensemblgenomes.org/id/AAC74898 EnsemblBacteria BAA15636 http://www.ensemblgenomes.org/id/BAA15636 EnsemblBacteria BAA15636 http://www.ensemblgenomes.org/id/BAA15636 EnsemblBacteria BAA15636 http://www.ensemblgenomes.org/id/BAA15636 EnsemblBacteria b1828 http://www.ensemblgenomes.org/id/b1828 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 946048 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946048 HOGENOM HOG000239125 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000239125&db=HOGENOM6 InParanoid P76269 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76269 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5299 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5299 KEGG_Gene eco:b1828 http://www.genome.jp/dbget-bin/www_bget?eco:b1828 KEGG_Orthology KO:K08169 http://www.genome.jp/dbget-bin/www_bget?KO:K08169 OMA MMGRSEV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MMGRSEV PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:YEBQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEBQ_ECOLI PSORT-B swissprot:YEBQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEBQ_ECOLI PSORT2 swissprot:YEBQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEBQ_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:YEBQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEBQ_ECOLI PhylomeDB P76269 http://phylomedb.org/?seqid=P76269 ProteinModelPortal P76269 http://www.proteinmodelportal.org/query/uniprot/P76269 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416342 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416342 RefSeq WP_001127216 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001127216 STRING 511145.b1828 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1828&targetmode=cogs STRING COG0477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0477&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.3.17 http://www.tcdb.org/search/result.php?tc=2.A.1.3.17 UniProtKB YEBQ_ECOLI http://www.uniprot.org/uniprot/YEBQ_ECOLI UniProtKB-AC P76269 http://www.uniprot.org/uniprot/P76269 charge swissprot:YEBQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEBQ_ECOLI eggNOG ENOG4105C0R http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C0R eggNOG ENOG410XNN3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNN3 epestfind swissprot:YEBQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEBQ_ECOLI garnier swissprot:YEBQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEBQ_ECOLI helixturnhelix swissprot:YEBQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEBQ_ECOLI hmoment swissprot:YEBQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEBQ_ECOLI iep swissprot:YEBQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEBQ_ECOLI inforesidue swissprot:YEBQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEBQ_ECOLI octanol swissprot:YEBQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEBQ_ECOLI pepcoil swissprot:YEBQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEBQ_ECOLI pepdigest swissprot:YEBQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEBQ_ECOLI pepinfo swissprot:YEBQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEBQ_ECOLI pepnet swissprot:YEBQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEBQ_ECOLI pepstats swissprot:YEBQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEBQ_ECOLI pepwheel swissprot:YEBQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEBQ_ECOLI pepwindow swissprot:YEBQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEBQ_ECOLI sigcleave swissprot:YEBQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEBQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4259249 11 # EcoGene EG13025 ygiW # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_process GO:0044011 single-species biofilm formation on inanimate substrate; IMP:EcoCyc. # GO_process GO:0070301 cellular response to hydrogen peroxide; IMP:EcoCyc. # GO_process GO:0071276 cellular response to cadmium ion; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # Gene3D 2.40.50.200 -; 1. # IntAct P0ADU5 2 # InterPro IPR005220 BOF # InterPro IPR016052 Phage_933W_L0136 # Organism YGIW_ECOLI Escherichia coli (strain K12) # PATRIC 32121460 VBIEscCol129921_3117 # PDB 1NNX X-ray; 1.45 A; A=22-130 # PIR F65089 F65089 # Pfam PF04076 BOF # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGIW_ECOLI Protein YgiW # RefSeq NP_417496 NC_000913.3 # RefSeq WP_000712658 NZ_LN832404.1 # SIMILARITY To H.influenzae HI_1709. {ECO 0000305}. # SUBCELLULAR LOCATION YGIW_ECOLI Periplasm {ECO 0000305}. # SUPFAM SSF101756 SSF101756 # TIGRFAMs TIGR00156 TIGR00156 # eggNOG COG3111 LUCA # eggNOG ENOG4105H4F Bacteria BLAST swissprot:YGIW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGIW_ECOLI BioCyc ECOL316407:JW2992-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2992-MONOMER BioCyc EcoCyc:G7574-MONOMER http://biocyc.org/getid?id=EcoCyc:G7574-MONOMER DIP DIP-47914N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47914N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2843 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2843 EcoGene EG13025 http://www.ecogene.org/geneInfo.php?eg_id=EG13025 EnsemblBacteria AAC76060 http://www.ensemblgenomes.org/id/AAC76060 EnsemblBacteria AAC76060 http://www.ensemblgenomes.org/id/AAC76060 EnsemblBacteria BAE77080 http://www.ensemblgenomes.org/id/BAE77080 EnsemblBacteria BAE77080 http://www.ensemblgenomes.org/id/BAE77080 EnsemblBacteria BAE77080 http://www.ensemblgenomes.org/id/BAE77080 EnsemblBacteria b3024 http://www.ensemblgenomes.org/id/b3024 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_process GO:0044011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044011 GO_process GO:0070301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070301 GO_process GO:0071276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071276 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 2.40.50.200 http://www.cathdb.info/version/latest/superfamily/2.40.50.200 GeneID 946051 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946051 HOGENOM HOG000216776 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000216776&db=HOGENOM6 InParanoid P0ADU5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADU5 IntAct P0ADU5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADU5* InterPro IPR005220 http://www.ebi.ac.uk/interpro/entry/IPR005220 InterPro IPR016052 http://www.ebi.ac.uk/interpro/entry/IPR016052 KEGG_Gene ecj:JW2992 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2992 KEGG_Gene eco:b3024 http://www.genome.jp/dbget-bin/www_bget?eco:b3024 MINT MINT-1219523 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1219523 OMA RWDGQTI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RWDGQTI PDB 1NNX http://www.ebi.ac.uk/pdbe-srv/view/entry/1NNX PDBsum 1NNX http://www.ebi.ac.uk/pdbsum/1NNX PSORT swissprot:YGIW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGIW_ECOLI PSORT-B swissprot:YGIW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGIW_ECOLI PSORT2 swissprot:YGIW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGIW_ECOLI Pfam PF04076 http://pfam.xfam.org/family/PF04076 Phobius swissprot:YGIW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGIW_ECOLI PhylomeDB P0ADU5 http://phylomedb.org/?seqid=P0ADU5 ProteinModelPortal P0ADU5 http://www.proteinmodelportal.org/query/uniprot/P0ADU5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_417496 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417496 RefSeq WP_000712658 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000712658 SMR P0ADU5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADU5 STRING 511145.b3024 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3024&targetmode=cogs SUPFAM SSF101756 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF101756 TIGRFAMs TIGR00156 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00156 UniProtKB YGIW_ECOLI http://www.uniprot.org/uniprot/YGIW_ECOLI UniProtKB-AC P0ADU5 http://www.uniprot.org/uniprot/P0ADU5 charge swissprot:YGIW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGIW_ECOLI eggNOG COG3111 http://eggnogapi.embl.de/nog_data/html/tree/COG3111 eggNOG ENOG4105H4F http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105H4F epestfind swissprot:YGIW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGIW_ECOLI garnier swissprot:YGIW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGIW_ECOLI helixturnhelix swissprot:YGIW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGIW_ECOLI hmoment swissprot:YGIW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGIW_ECOLI iep swissprot:YGIW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGIW_ECOLI inforesidue swissprot:YGIW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGIW_ECOLI octanol swissprot:YGIW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGIW_ECOLI pepcoil swissprot:YGIW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGIW_ECOLI pepdigest swissprot:YGIW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGIW_ECOLI pepinfo swissprot:YGIW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGIW_ECOLI pepnet swissprot:YGIW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGIW_ECOLI pepstats swissprot:YGIW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGIW_ECOLI pepwheel swissprot:YGIW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGIW_ECOLI pepwindow swissprot:YGIW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGIW_ECOLI sigcleave swissprot:YGIW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGIW_ECOLI ## Database ID URL or Descriptions # AltName FABB_ECOLI 3-oxoacyl-[acyl-carrier-protein] synthase I # AltName FABB_ECOLI Beta-ketoacyl-ACP synthase I # BRENDA 2.3.1.41 2026 # BioGrid 4260793 224 # CATALYTIC ACTIVITY FABB_ECOLI Acyl-[acyl-carrier-protein] + malonyl-[acyl- carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO(2) + [acyl-carrier-protein]. # DrugBank DB01034 Cerulenin # EcoGene EG10274 fabB # FUNCTION FABB_ECOLI Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids. {ECO 0000269|PubMed 3076377}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity; IDA:EcoCyc. # GO_process GO:0006633 fatty acid biosynthetic process; IMP:EcoCyc. # GO_process GO:0008610 lipid biosynthetic process; IGI:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.47.10 -; 2. # INDUCTION FABB_ECOLI Mainly activated by FadR, but minor repression is also conferred by FabR (PubMed 11859088, PubMed 21276098). {ECO 0000269|PubMed 11859088, ECO 0000269|PubMed 21276098}. # IntAct P0A953 9 # InterPro IPR014030 Ketoacyl_synth_N # InterPro IPR014031 Ketoacyl_synth_C # InterPro IPR016039 Thiolase-like # InterPro IPR018201 Ketoacyl_synth_AS # InterPro IPR020841 PKS_Beta-ketoAc_synthase_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01004 Lipid biosynthesis proteins # KEGG_Pathway ko00061 Fatty acid biosynthesis # KEGG_Pathway ko00780 Biotin metabolism # Organism FABB_ECOLI Escherichia coli (strain K12) # PATHWAY FABB_ECOLI Lipid metabolism; fatty acid biosynthesis. # PATRIC 32120019 VBIEscCol129921_2419 # PDB 1DD8 X-ray; 2.30 A; A/B/C/D=1-406 # PDB 1EK4 X-ray; 1.85 A; A/B/C/D=1-406 # PDB 1F91 X-ray; 2.40 A; A/B/C/D=1-406 # PDB 1FJ4 X-ray; 2.35 A; A/B/C/D=1-406 # PDB 1FJ8 X-ray; 2.27 A; A/B/C/D=1-406 # PDB 1G5X X-ray; 2.45 A; A/B/C/D=1-406 # PDB 1H4F X-ray; 2.00 A; A/B/C/D=1-406 # PDB 2AQ7 X-ray; 2.30 A; A/B/C/D=1-406 # PDB 2AQB X-ray; 2.19 A; A/B/C/D=1-406 # PDB 2BUH X-ray; 1.90 A; A/B/C/D=1-406 # PDB 2BUI X-ray; 2.40 A; A/B/C/D=1-406 # PDB 2BYW X-ray; 1.70 A; A/B/C/D=5-406 # PDB 2BYX X-ray; 2.00 A; A/B/C/D=5-406 # PDB 2BYY X-ray; 2.20 A; A/B/C/D=1-406 # PDB 2BYZ X-ray; 1.95 A; A/B/C/D=1-406 # PDB 2BZ3 X-ray; 2.00 A; A/B/C/D=1-406 # PDB 2BZ4 X-ray; 1.86 A; A/B/C/D=1-406 # PDB 2CDH X-ray; 4.20 A; A/B/C/D/E/F=1-406 # PDB 2CF2 X-ray; 4.30 A; A/J=1-406 # PDB 2VB7 X-ray; 1.60 A; A/B/C/D=1-406 # PDB 2VB8 X-ray; 1.52 A; A/B/C/D=1-406 # PDB 2VB9 X-ray; 1.50 A; A/B/C/D=1-406 # PDB 2VBA X-ray; 1.36 A; A/B/C/D=1-406 # PIR A31284 SYECA1 # PROSITE PS00606 B_KETOACYL_SYNTHASE # Pfam PF00109 ketoacyl-synt # Pfam PF02801 Ketoacyl-synt_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FABB_ECOLI 3-oxoacyl-[acyl-carrier-protein] synthase 1 # RefSeq NP_416826 NC_000913.3 # RefSeq WP_000817178 NZ_LN832404.1 # SIMILARITY Belongs to the beta-ketoacyl-ACP synthases family. {ECO 0000305}. # SMART SM00825 PKS_KS # SUBCELLULAR LOCATION FABB_ECOLI Cytoplasm. # SUBUNIT FABB_ECOLI Homodimer. # SUPFAM SSF53901 SSF53901; 2 # eggNOG COG0304 LUCA # eggNOG ENOG4105C0Q Bacteria BLAST swissprot:FABB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FABB_ECOLI BioCyc ECOL316407:JW2320-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2320-MONOMER BioCyc EcoCyc:FABB-MONOMER http://biocyc.org/getid?id=EcoCyc:FABB-MONOMER BioCyc MetaCyc:FABB-MONOMER http://biocyc.org/getid?id=MetaCyc:FABB-MONOMER COG COG0304 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0304 DIP DIP-29379N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-29379N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1007/BF02983311 http://dx.doi.org/10.1007/BF02983311 DOI 10.1007/BF02983312 http://dx.doi.org/10.1007/BF02983312 DOI 10.1016/S0014-5793(99)01303-4 http://dx.doi.org/10.1016/S0014-5793(99)01303-4 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M201399200 http://dx.doi.org/10.1074/jbc.M201399200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1365-2958.2011.07564.x http://dx.doi.org/10.1111/j.1365-2958.2011.07564.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB01034 http://www.drugbank.ca/drugs/DB01034 EC_number EC:2.3.1.41 http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.41 EMBL AJ012161 http://www.ebi.ac.uk/ena/data/view/AJ012161 EMBL AJ012162 http://www.ebi.ac.uk/ena/data/view/AJ012162 EMBL AJ012163 http://www.ebi.ac.uk/ena/data/view/AJ012163 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M24427 http://www.ebi.ac.uk/ena/data/view/M24427 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.3.1.41 http://enzyme.expasy.org/EC/2.3.1.41 EchoBASE EB0270 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0270 EcoGene EG10274 http://www.ecogene.org/geneInfo.php?eg_id=EG10274 EnsemblBacteria AAC75383 http://www.ensemblgenomes.org/id/AAC75383 EnsemblBacteria AAC75383 http://www.ensemblgenomes.org/id/AAC75383 EnsemblBacteria BAA16180 http://www.ensemblgenomes.org/id/BAA16180 EnsemblBacteria BAA16180 http://www.ensemblgenomes.org/id/BAA16180 EnsemblBacteria BAA16180 http://www.ensemblgenomes.org/id/BAA16180 EnsemblBacteria b2323 http://www.ensemblgenomes.org/id/b2323 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004315 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004315 GO_process GO:0006633 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006633 GO_process GO:0008610 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008610 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.47.10 http://www.cathdb.info/version/latest/superfamily/3.40.47.10 GeneID 946799 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946799 HOGENOM HOG000060165 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000060165&db=HOGENOM6 InParanoid P0A953 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A953 IntAct P0A953 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A953* IntEnz 2.3.1.41 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.41 InterPro IPR014030 http://www.ebi.ac.uk/interpro/entry/IPR014030 InterPro IPR014031 http://www.ebi.ac.uk/interpro/entry/IPR014031 InterPro IPR016039 http://www.ebi.ac.uk/interpro/entry/IPR016039 InterPro IPR018201 http://www.ebi.ac.uk/interpro/entry/IPR018201 InterPro IPR020841 http://www.ebi.ac.uk/interpro/entry/IPR020841 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01004 http://www.genome.jp/dbget-bin/www_bget?ko01004 KEGG_Gene ecj:JW2320 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2320 KEGG_Gene eco:b2323 http://www.genome.jp/dbget-bin/www_bget?eco:b2323 KEGG_Orthology KO:K00647 http://www.genome.jp/dbget-bin/www_bget?KO:K00647 KEGG_Pathway ko00061 http://www.genome.jp/kegg-bin/show_pathway?ko00061 KEGG_Pathway ko00780 http://www.genome.jp/kegg-bin/show_pathway?ko00780 KEGG_Reaction rn:R04355 http://www.genome.jp/dbget-bin/www_bget?rn:R04355 KEGG_Reaction rn:R04726 http://www.genome.jp/dbget-bin/www_bget?rn:R04726 KEGG_Reaction rn:R04952 http://www.genome.jp/dbget-bin/www_bget?rn:R04952 KEGG_Reaction rn:R04957 http://www.genome.jp/dbget-bin/www_bget?rn:R04957 KEGG_Reaction rn:R04960 http://www.genome.jp/dbget-bin/www_bget?rn:R04960 KEGG_Reaction rn:R04963 http://www.genome.jp/dbget-bin/www_bget?rn:R04963 KEGG_Reaction rn:R04968 http://www.genome.jp/dbget-bin/www_bget?rn:R04968 KEGG_Reaction rn:R07762 http://www.genome.jp/dbget-bin/www_bget?rn:R07762 KEGG_Reaction rn:R10115 http://www.genome.jp/dbget-bin/www_bget?rn:R10115 KEGG_Reaction rn:R10119 http://www.genome.jp/dbget-bin/www_bget?rn:R10119 MINT MINT-1235843 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1235843 OMA HCIGTAL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HCIGTAL PDB 1DD8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1DD8 PDB 1EK4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1EK4 PDB 1F91 http://www.ebi.ac.uk/pdbe-srv/view/entry/1F91 PDB 1FJ4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1FJ4 PDB 1FJ8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1FJ8 PDB 1G5X http://www.ebi.ac.uk/pdbe-srv/view/entry/1G5X PDB 1H4F http://www.ebi.ac.uk/pdbe-srv/view/entry/1H4F PDB 2AQ7 http://www.ebi.ac.uk/pdbe-srv/view/entry/2AQ7 PDB 2AQB http://www.ebi.ac.uk/pdbe-srv/view/entry/2AQB PDB 2BUH http://www.ebi.ac.uk/pdbe-srv/view/entry/2BUH PDB 2BUI http://www.ebi.ac.uk/pdbe-srv/view/entry/2BUI PDB 2BYW http://www.ebi.ac.uk/pdbe-srv/view/entry/2BYW PDB 2BYX http://www.ebi.ac.uk/pdbe-srv/view/entry/2BYX PDB 2BYY http://www.ebi.ac.uk/pdbe-srv/view/entry/2BYY PDB 2BYZ http://www.ebi.ac.uk/pdbe-srv/view/entry/2BYZ PDB 2BZ3 http://www.ebi.ac.uk/pdbe-srv/view/entry/2BZ3 PDB 2BZ4 http://www.ebi.ac.uk/pdbe-srv/view/entry/2BZ4 PDB 2CDH http://www.ebi.ac.uk/pdbe-srv/view/entry/2CDH PDB 2CF2 http://www.ebi.ac.uk/pdbe-srv/view/entry/2CF2 PDB 2VB7 http://www.ebi.ac.uk/pdbe-srv/view/entry/2VB7 PDB 2VB8 http://www.ebi.ac.uk/pdbe-srv/view/entry/2VB8 PDB 2VB9 http://www.ebi.ac.uk/pdbe-srv/view/entry/2VB9 PDB 2VBA http://www.ebi.ac.uk/pdbe-srv/view/entry/2VBA PDBsum 1DD8 http://www.ebi.ac.uk/pdbsum/1DD8 PDBsum 1EK4 http://www.ebi.ac.uk/pdbsum/1EK4 PDBsum 1F91 http://www.ebi.ac.uk/pdbsum/1F91 PDBsum 1FJ4 http://www.ebi.ac.uk/pdbsum/1FJ4 PDBsum 1FJ8 http://www.ebi.ac.uk/pdbsum/1FJ8 PDBsum 1G5X http://www.ebi.ac.uk/pdbsum/1G5X PDBsum 1H4F http://www.ebi.ac.uk/pdbsum/1H4F PDBsum 2AQ7 http://www.ebi.ac.uk/pdbsum/2AQ7 PDBsum 2AQB http://www.ebi.ac.uk/pdbsum/2AQB PDBsum 2BUH http://www.ebi.ac.uk/pdbsum/2BUH PDBsum 2BUI http://www.ebi.ac.uk/pdbsum/2BUI PDBsum 2BYW http://www.ebi.ac.uk/pdbsum/2BYW PDBsum 2BYX http://www.ebi.ac.uk/pdbsum/2BYX PDBsum 2BYY http://www.ebi.ac.uk/pdbsum/2BYY PDBsum 2BYZ http://www.ebi.ac.uk/pdbsum/2BYZ PDBsum 2BZ3 http://www.ebi.ac.uk/pdbsum/2BZ3 PDBsum 2BZ4 http://www.ebi.ac.uk/pdbsum/2BZ4 PDBsum 2CDH http://www.ebi.ac.uk/pdbsum/2CDH PDBsum 2CF2 http://www.ebi.ac.uk/pdbsum/2CF2 PDBsum 2VB7 http://www.ebi.ac.uk/pdbsum/2VB7 PDBsum 2VB8 http://www.ebi.ac.uk/pdbsum/2VB8 PDBsum 2VB9 http://www.ebi.ac.uk/pdbsum/2VB9 PDBsum 2VBA http://www.ebi.ac.uk/pdbsum/2VBA PROSITE PS00606 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00606 PSORT swissprot:FABB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FABB_ECOLI PSORT-B swissprot:FABB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FABB_ECOLI PSORT2 swissprot:FABB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FABB_ECOLI Pfam PF00109 http://pfam.xfam.org/family/PF00109 Pfam PF02801 http://pfam.xfam.org/family/PF02801 Phobius swissprot:FABB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FABB_ECOLI PhylomeDB P0A953 http://phylomedb.org/?seqid=P0A953 ProteinModelPortal P0A953 http://www.proteinmodelportal.org/query/uniprot/P0A953 PubMed 10571059 http://www.ncbi.nlm.nih.gov/pubmed/10571059 PubMed 11859088 http://www.ncbi.nlm.nih.gov/pubmed/11859088 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21276098 http://www.ncbi.nlm.nih.gov/pubmed/21276098 PubMed 3076376 http://www.ncbi.nlm.nih.gov/pubmed/3076376 PubMed 3076377 http://www.ncbi.nlm.nih.gov/pubmed/3076377 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_416826 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416826 RefSeq WP_000817178 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000817178 SMART SM00825 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00825 SMR P0A953 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A953 STRING 511145.b2323 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2323&targetmode=cogs STRING COG0304 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0304&targetmode=cogs SUPFAM SSF53901 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53901 UniProtKB FABB_ECOLI http://www.uniprot.org/uniprot/FABB_ECOLI UniProtKB-AC P0A953 http://www.uniprot.org/uniprot/P0A953 charge swissprot:FABB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FABB_ECOLI eggNOG COG0304 http://eggnogapi.embl.de/nog_data/html/tree/COG0304 eggNOG ENOG4105C0Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C0Q epestfind swissprot:FABB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FABB_ECOLI garnier swissprot:FABB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FABB_ECOLI helixturnhelix swissprot:FABB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FABB_ECOLI hmoment swissprot:FABB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FABB_ECOLI iep swissprot:FABB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FABB_ECOLI inforesidue swissprot:FABB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FABB_ECOLI octanol swissprot:FABB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FABB_ECOLI pepcoil swissprot:FABB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FABB_ECOLI pepdigest swissprot:FABB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FABB_ECOLI pepinfo swissprot:FABB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FABB_ECOLI pepnet swissprot:FABB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FABB_ECOLI pepstats swissprot:FABB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FABB_ECOLI pepwheel swissprot:FABB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FABB_ECOLI pepwindow swissprot:FABB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FABB_ECOLI sigcleave swissprot:FABB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FABB_ECOLI ## Database ID URL or Descriptions # BioGrid 4259352 8 # EcoGene EG13701 ycaQ # IntAct P75843 3 # InterPro IPR009351 DUF1006 # Organism YCAQ_ECOLI Escherichia coli (strain K12) # PATRIC 32117045 VBIEscCol129921_0947 # PIR C64831 C64831 # Pfam PF06224 HTH_42 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCAQ_ECOLI Uncharacterized protein YcaQ # RefSeq NP_415436 NC_000913.3 # RefSeq WP_000056538 NZ_LN832404.1 # eggNOG COG3214 LUCA # eggNOG ENOG4105T0Z Bacteria BLAST swissprot:YCAQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCAQ_ECOLI BioCyc ECOL316407:JW0899-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0899-MONOMER BioCyc EcoCyc:G6471-MONOMER http://biocyc.org/getid?id=EcoCyc:G6471-MONOMER COG COG3214 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3214 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3465 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3465 EcoGene EG13701 http://www.ecogene.org/geneInfo.php?eg_id=EG13701 EnsemblBacteria AAC74002 http://www.ensemblgenomes.org/id/AAC74002 EnsemblBacteria AAC74002 http://www.ensemblgenomes.org/id/AAC74002 EnsemblBacteria BAA35662 http://www.ensemblgenomes.org/id/BAA35662 EnsemblBacteria BAA35662 http://www.ensemblgenomes.org/id/BAA35662 EnsemblBacteria BAA35662 http://www.ensemblgenomes.org/id/BAA35662 EnsemblBacteria b0916 http://www.ensemblgenomes.org/id/b0916 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945524 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945524 HOGENOM HOG000215688 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000215688&db=HOGENOM6 InParanoid P75843 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75843 IntAct P75843 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75843* InterPro IPR009351 http://www.ebi.ac.uk/interpro/entry/IPR009351 KEGG_Gene ecj:JW0899 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0899 KEGG_Gene eco:b0916 http://www.genome.jp/dbget-bin/www_bget?eco:b0916 KEGG_Orthology KO:K09927 http://www.genome.jp/dbget-bin/www_bget?KO:K09927 OMA WGHEASL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WGHEASL PSORT swissprot:YCAQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCAQ_ECOLI PSORT-B swissprot:YCAQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCAQ_ECOLI PSORT2 swissprot:YCAQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCAQ_ECOLI Pfam PF06224 http://pfam.xfam.org/family/PF06224 Phobius swissprot:YCAQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCAQ_ECOLI PhylomeDB P75843 http://phylomedb.org/?seqid=P75843 ProteinModelPortal P75843 http://www.proteinmodelportal.org/query/uniprot/P75843 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415436 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415436 RefSeq WP_000056538 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000056538 STRING 511145.b0916 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0916&targetmode=cogs STRING COG3214 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3214&targetmode=cogs UniProtKB YCAQ_ECOLI http://www.uniprot.org/uniprot/YCAQ_ECOLI UniProtKB-AC P75843 http://www.uniprot.org/uniprot/P75843 charge swissprot:YCAQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCAQ_ECOLI eggNOG COG3214 http://eggnogapi.embl.de/nog_data/html/tree/COG3214 eggNOG ENOG4105T0Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105T0Z epestfind swissprot:YCAQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCAQ_ECOLI garnier swissprot:YCAQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCAQ_ECOLI helixturnhelix swissprot:YCAQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCAQ_ECOLI hmoment swissprot:YCAQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCAQ_ECOLI iep swissprot:YCAQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCAQ_ECOLI inforesidue swissprot:YCAQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCAQ_ECOLI octanol swissprot:YCAQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCAQ_ECOLI pepcoil swissprot:YCAQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCAQ_ECOLI pepdigest swissprot:YCAQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCAQ_ECOLI pepinfo swissprot:YCAQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCAQ_ECOLI pepnet swissprot:YCAQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCAQ_ECOLI pepstats swissprot:YCAQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCAQ_ECOLI pepwheel swissprot:YCAQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCAQ_ECOLI pepwindow swissprot:YCAQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCAQ_ECOLI sigcleave swissprot:YCAQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCAQ_ECOLI ## Database ID URL or Descriptions # AltName EII-Gut {ECO:0000303|PubMed 3553176} # AltName Enzyme II-Gut {ECO:0000303|PubMed 3553176} # AltName Glucitol/sorbitol-specific phosphotransferase enzyme IIB component {ECO:0000303|PubMed 3553176} # BIOPHYSICOCHEMICAL PROPERTIES PTHB_ECOLI Kinetic parameters KM=44 uM for D-glucitol {ECO 0000269|PubMed 1100608}; KM=60 uM for D-mannitol {ECO 0000269|PubMed 1100608}; Vmax=7.2 nmol/min/mg enzyme with D-mannitol as substrate {ECO 0000269|PubMed 1100608}; Vmax=0.83 nmol/min/mg enzyme with D-glucitol as substrate {ECO 0000269|PubMed 1100608}; # BioGrid 4262075 19 # CATALYTIC ACTIVITY [Protein]-N(pi)-phospho-L-histidine + D- sorbitol(Side 1) = [protein]-L-histidine + D-sorbitol 6- phosphate(Side 2). {ECO:0000269|PubMed 1100608}. # DOMAIN PTHB_ECOLI The EIIB domain is phosphorylated by phospho-EIIA on a cysteinyl or histidyl residue, depending on the transported sugar. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the EIIC domain. {ECO 0000255|PROSITE-ProRule PRU00425}. # EcoGene EG14373 srlE # FUNCTION PTHB_ECOLI The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II complex composed of SrlA, SrlB and SrlE is involved in glucitol/sorbitol transport. It can also use D- mannitol. {ECO 0000269|PubMed 1100608}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0008982 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:InterPro. # GO_function GO:0016301 kinase activity; IEA:UniProtKB-KW. # GO_function GO:0090563 protein-phosphocysteine-sugar phosphotransferase activity; IDA:UniProtKB. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IDA:UniProtKB. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # INDUCTION Regulated by an unusual system which consists of the activator GutM and the repressor GutR in addition to the cAMP-CRP complex. {ECO:0000269|PubMed 3062173}. # InterPro IPR004702 PTS_sorb_EIIBC # InterPro IPR011618 PTS_EIIBC_GUT_N # InterPro IPR011638 PTS_EIIBC_GUT_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00280 PTS system, glucitol/sorbitol-specific II component # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko00051 Fructose and mannose metabolism # KEGG_Pathway ko02060 Phosphotransferase system (PTS) # Organism PTHB_ECOLI Escherichia coli (strain K12) # PATRIC 32120804 VBIEscCol129921_2794 # PIR A26725 WQEC2S # PROSITE PS51102 PTS_EIIB_TYPE_5 # Pfam PF03612 EIIBC-GUT_N # Pfam PF07663 EIIBC-GUT_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PTS system glucitol/sorbitol-specific EIIB component {ECO:0000303|PubMed 3553176} # RefSeq WP_000148878 NZ_LN832404.1 # RefSeq YP_026181 NC_000913.3 # SIMILARITY Contains 1 PTS EIIB type-5 domain. {ECO:0000255|PROSITE-ProRule PRU00425}. # SUBCELLULAR LOCATION PTHB_ECOLI Cell inner membrane {ECO 0000305|PubMed 3553176}; Multi-pass membrane protein {ECO 0000255, ECO 0000305|PubMed 3553176}. # TCDB 4.A.4.1 the pts glucitol (gut) family # TIGRFAMs TIGR00825 EIIBC-GUT # eggNOG COG3732 LUCA # eggNOG ENOG4105DZY Bacteria BLAST swissprot:PTHB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTHB_ECOLI BioCyc ECOL316407:JW5430-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5430-MONOMER BioCyc EcoCyc:GUTA-MONOMER http://biocyc.org/getid?id=EcoCyc:GUTA-MONOMER BioCyc MetaCyc:GUTA-MONOMER http://biocyc.org/getid?id=MetaCyc:GUTA-MONOMER COG COG3730 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3730 COG COG3732 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3732 DOI 10.1016/0022-2836(88)90193-3 http://dx.doi.org/10.1016/0022-2836(88)90193-3 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.198 {ECO:0000269|PubMed:1100608} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.198 {ECO:0000269|PubMed:1100608} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J02708 http://www.ebi.ac.uk/ena/data/view/J02708 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.198 {ECO:0000269|PubMed:1100608} http://enzyme.expasy.org/EC/2.7.1.198 {ECO:0000269|PubMed:1100608} EchoBASE EB4116 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4116 EcoGene EG14373 http://www.ecogene.org/geneInfo.php?eg_id=EG14373 EnsemblBacteria AAT48149 http://www.ensemblgenomes.org/id/AAT48149 EnsemblBacteria AAT48149 http://www.ensemblgenomes.org/id/AAT48149 EnsemblBacteria BAA16564 http://www.ensemblgenomes.org/id/BAA16564 EnsemblBacteria BAA16564 http://www.ensemblgenomes.org/id/BAA16564 EnsemblBacteria BAA16564 http://www.ensemblgenomes.org/id/BAA16564 EnsemblBacteria b2703 http://www.ensemblgenomes.org/id/b2703 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008982 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008982 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_function GO:0090563 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090563 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948933 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948933 HOGENOM HOG000242653 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000242653&db=HOGENOM6 InParanoid P56580 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P56580 IntEnz 2.7.1.198 {ECO:0000269|PubMed:1100608} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.198 {ECO:0000269|PubMed:1100608} InterPro IPR004702 http://www.ebi.ac.uk/interpro/entry/IPR004702 InterPro IPR011618 http://www.ebi.ac.uk/interpro/entry/IPR011618 InterPro IPR011638 http://www.ebi.ac.uk/interpro/entry/IPR011638 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5430 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5430 KEGG_Gene eco:b2703 http://www.genome.jp/dbget-bin/www_bget?eco:b2703 KEGG_Orthology KO:K02783 http://www.genome.jp/dbget-bin/www_bget?KO:K02783 KEGG_Pathway ko00051 http://www.genome.jp/kegg-bin/show_pathway?ko00051 KEGG_Pathway ko02060 http://www.genome.jp/kegg-bin/show_pathway?ko02060 KEGG_Reaction rn:R05820 http://www.genome.jp/dbget-bin/www_bget?rn:R05820 OMA ALAIVDC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ALAIVDC PROSITE PS51102 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51102 PSORT swissprot:PTHB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTHB_ECOLI PSORT-B swissprot:PTHB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTHB_ECOLI PSORT2 swissprot:PTHB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTHB_ECOLI Pfam PF03612 http://pfam.xfam.org/family/PF03612 Pfam PF07663 http://pfam.xfam.org/family/PF07663 Phobius swissprot:PTHB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTHB_ECOLI PhylomeDB P56580 http://phylomedb.org/?seqid=P56580 ProteinModelPortal P56580 http://www.proteinmodelportal.org/query/uniprot/P56580 PubMed 1100608 http://www.ncbi.nlm.nih.gov/pubmed/1100608 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3062173 http://www.ncbi.nlm.nih.gov/pubmed/3062173 PubMed 3553176 http://www.ncbi.nlm.nih.gov/pubmed/3553176 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000148878 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000148878 RefSeq YP_026181 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026181 STRING 511145.b2703 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2703&targetmode=cogs STRING COG3730 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3730&targetmode=cogs STRING COG3732 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3732&targetmode=cogs TCDB 4.A.4.1 http://www.tcdb.org/search/result.php?tc=4.A.4.1 TIGRFAMs TIGR00825 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00825 UniProtKB PTHB_ECOLI http://www.uniprot.org/uniprot/PTHB_ECOLI UniProtKB-AC P56580 http://www.uniprot.org/uniprot/P56580 charge swissprot:PTHB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTHB_ECOLI eggNOG COG3732 http://eggnogapi.embl.de/nog_data/html/tree/COG3732 eggNOG ENOG4105DZY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DZY epestfind swissprot:PTHB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTHB_ECOLI garnier swissprot:PTHB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTHB_ECOLI helixturnhelix swissprot:PTHB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTHB_ECOLI hmoment swissprot:PTHB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTHB_ECOLI iep swissprot:PTHB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTHB_ECOLI inforesidue swissprot:PTHB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTHB_ECOLI octanol swissprot:PTHB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTHB_ECOLI pepcoil swissprot:PTHB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTHB_ECOLI pepdigest swissprot:PTHB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTHB_ECOLI pepinfo swissprot:PTHB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTHB_ECOLI pepnet swissprot:PTHB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTHB_ECOLI pepstats swissprot:PTHB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTHB_ECOLI pepwheel swissprot:PTHB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTHB_ECOLI pepwindow swissprot:PTHB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTHB_ECOLI sigcleave swissprot:PTHB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTHB_ECOLI ## Database ID URL or Descriptions # DISRUPTION PHENOTYPE None seen. An isbB overproducing strain cannot be made in the absence of the sibB gene. {ECO:0000269|PubMed 18710431}. # EcoGene EG14473 ibsB # FUNCTION IBSB_ECOLI May be a toxic protein; overexpression causes cessation of growth. # INDUCTION The sibB sRNA probably represses expression of ibsB mRNA, either by destabilizing the transcript and/or preventing its translation (Probable). A type I toxin antitoxin (TA) system, where expression of the proteinaceous toxin is controlled by an antisense sRNA. {ECO 0000305}. # InterPro IPR025881 Toxin_Ibs # MISCELLANEOUS IBSB_ECOLI Part of the SIBb repeat region (formerly known as QUAD1b), encoded on the opposite strand from the sibB (formerly knowny as ryeD) RNA. # Organism IBSB_ECOLI Escherichia coli (strain K12) # Pfam PF13956 Ibs_toxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName IBSB_ECOLI Small toxic protein IbsB # RefSeq YP_002791248 NC_000913.3 # SIMILARITY Belongs to the toxic protein ibs family. {ECO 0000305}. BLAST swissprot:IBSB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:IBSB_ECOLI BioCyc EcoCyc:MONOMER0-2858 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2858 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2008.06394.x http://dx.doi.org/10.1111/j.1365-2958.2008.06394.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14473 http://www.ecogene.org/geneInfo.php?eg_id=EG14473 EnsemblBacteria ACO60000 http://www.ensemblgenomes.org/id/ACO60000 EnsemblBacteria ACO60000 http://www.ensemblgenomes.org/id/ACO60000 EnsemblBacteria b4668 http://www.ensemblgenomes.org/id/b4668 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 7751626 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7751626 InterPro IPR025881 http://www.ebi.ac.uk/interpro/entry/IPR025881 KEGG_Gene eco:b4668 http://www.genome.jp/dbget-bin/www_bget?eco:b4668 PSORT swissprot:IBSB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:IBSB_ECOLI PSORT-B swissprot:IBSB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:IBSB_ECOLI PSORT2 swissprot:IBSB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:IBSB_ECOLI Pfam PF13956 http://pfam.xfam.org/family/PF13956 Phobius swissprot:IBSB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:IBSB_ECOLI PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18710431 http://www.ncbi.nlm.nih.gov/pubmed/18710431 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq YP_002791248 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_002791248 UniProtKB IBSB_ECOLI http://www.uniprot.org/uniprot/IBSB_ECOLI UniProtKB-AC C1P608 http://www.uniprot.org/uniprot/C1P608 charge swissprot:IBSB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:IBSB_ECOLI epestfind swissprot:IBSB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:IBSB_ECOLI garnier swissprot:IBSB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:IBSB_ECOLI helixturnhelix swissprot:IBSB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:IBSB_ECOLI hmoment swissprot:IBSB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:IBSB_ECOLI iep swissprot:IBSB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:IBSB_ECOLI inforesidue swissprot:IBSB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:IBSB_ECOLI octanol swissprot:IBSB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:IBSB_ECOLI pepcoil swissprot:IBSB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:IBSB_ECOLI pepdigest swissprot:IBSB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:IBSB_ECOLI pepinfo swissprot:IBSB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:IBSB_ECOLI pepnet swissprot:IBSB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:IBSB_ECOLI pepstats swissprot:IBSB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:IBSB_ECOLI pepwheel swissprot:IBSB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:IBSB_ECOLI pepwindow swissprot:IBSB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:IBSB_ECOLI sigcleave swissprot:IBSB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:IBSB_ECOLI ## Database ID URL or Descriptions # AltName AMPC_ECOLI Cephalosporinase # BRENDA 3.5.2 2026 # BioGrid 4261277 161 # CATALYTIC ACTIVITY A beta-lactam + H(2)O = a substituted beta- amino acid. {ECO:0000255|PROSITE-ProRule PRU10102}. # DrugBank DB00456 Cefalotin # DrugBank DB01147 Cloxacillin # EcoGene EG10040 ampC # FUNCTION AMPC_ECOLI This protein is a serine beta-lactamase with a substrate specificity for cephalosporins. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IEA:InterPro. # GO_function GO:0008800 beta-lactamase activity; IDA:EcoliWiki. # GO_process GO:0017001 antibiotic catabolic process; IEA:InterPro. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # Gene3D 3.40.710.10 -; 1. # InterPro IPR001466 Beta-lactam-related # InterPro IPR001586 Beta-lactam_class-C_AS # InterPro IPR012338 Beta-lactam/transpept-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00311 Penicillin and cephalosporin biosynthesis # KEGG_Pathway ko00312 beta-Lactam resistance # KEGG_Pathway ko02020 Two-component system # Organism AMPC_ECOLI Escherichia coli (strain K12) # PATRIC 32123873 VBIEscCol129921_4284 # PDB 1C3B X-ray; 2.25 A; A/B=20-377 # PDB 1FCM X-ray; 2.46 A; A/B=20-377 # PDB 1FCN X-ray; 2.35 A; A/B=20-377 # PDB 1FCO X-ray; 2.20 A; A/B=20-377 # PDB 1FSW X-ray; 1.90 A; A/B=20-376 # PDB 1FSY X-ray; 1.75 A; A/B=20-376 # PDB 1GA9 X-ray; 2.10 A; A/B=20-377 # PDB 1I5Q X-ray; 1.83 A; A/B=20-377 # PDB 1IEL X-ray; 2.00 A; A/B=20-377 # PDB 1IEM X-ray; 2.30 A; A/B=20-377 # PDB 1KDS X-ray; 2.15 A; A/B=20-377 # PDB 1KDW X-ray; 2.28 A; A/B=20-377 # PDB 1KE0 X-ray; 2.30 A; A/B=20-377 # PDB 1KE3 X-ray; 2.15 A; A/B=20-377 # PDB 1KE4 X-ray; 1.72 A; A/B=20-377 # PDB 1KVL X-ray; 1.53 A; A/B=20-377 # PDB 1KVM X-ray; 2.06 A; A/B=20-377 # PDB 1L0D X-ray; 1.53 A; A/B=20-377 # PDB 1L0E X-ray; 1.90 A; A/B=20-377 # PDB 1L0F X-ray; 1.66 A; A/B=20-377 # PDB 1L0G X-ray; 1.50 A; A/B=20-377 # PDB 1L2S X-ray; 1.94 A; A/B=20-377 # PDB 1LL5 X-ray; 1.80 A; A/B=20-377 # PDB 1LL9 X-ray; 1.87 A; A/B=20-377 # PDB 1LLB X-ray; 1.72 A; A/B=20-377 # PDB 1MXO X-ray; 1.83 A; A/B=20-377 # PDB 1MY8 X-ray; 1.72 A; A/B=20-377 # PDB 1O07 X-ray; 1.71 A; A/B=20-377 # PDB 1PI4 X-ray; 1.39 A; A/B=20-377 # PDB 1PI5 X-ray; 1.49 A; A/B=20-377 # PDB 1XGI X-ray; 1.96 A; A/B=20-377 # PDB 1XGJ X-ray; 1.97 A; A/B=20-377 # PDB 2BLS X-ray; 2.00 A; A/B=20-377 # PDB 2FFY X-ray; 1.07 A; A/B=20-377 # PDB 2HDQ X-ray; 2.10 A; A/B=20-377 # PDB 2HDR X-ray; 2.20 A; A/B=20-377 # PDB 2HDS X-ray; 1.16 A; A/B=20-377 # PDB 2HDU X-ray; 1.49 A; A/B=20-377 # PDB 2I72 X-ray; 2.20 A; A/B=20-377 # PDB 2P9V X-ray; 1.80 A; A/B=20-377 # PDB 2PU2 X-ray; 1.86 A; A/B=20-377 # PDB 2PU4 X-ray; 2.00 A; A/B=20-377 # PDB 2R9W X-ray; 1.80 A; A/B=20-377 # PDB 2R9X X-ray; 1.90 A; A/B=20-377 # PDB 2RCX X-ray; 2.00 A; A/B=20-377 # PDB 3BLS X-ray; 2.30 A; A/B=20-377 # PDB 3BM6 X-ray; 2.10 A; A/B=20-377 # PDB 3FKV X-ray; 1.85 A; A/B=20-377 # PDB 3FKW X-ray; 1.50 A; A/B=20-377 # PDB 3GQZ X-ray; 1.80 A; A/B=20-377 # PDB 3GR2 X-ray; 1.80 A; A/B=20-377 # PDB 3GRJ X-ray; 2.49 A; A/B=20-377 # PDB 3GSG X-ray; 2.10 A; A/B=20-377 # PDB 3GTC X-ray; 1.90 A; A/B=20-377 # PDB 3GV9 X-ray; 1.80 A; A/B=20-377 # PDB 3GVB X-ray; 1.80 A; A/B=20-377 # PDB 3IWI X-ray; 1.64 A; A/B=20-377 # PDB 3IWO X-ray; 1.90 A; A/B=20-377 # PDB 3IWQ X-ray; 1.84 A; A/B=20-377 # PDB 3IXB X-ray; 1.63 A; A/B=20-377 # PDB 3IXD X-ray; 2.64 A; A/B=20-377 # PDB 3IXG X-ray; 2.14 A; A/B=20-377 # PDB 3IXH X-ray; 2.30 A; A/B=20-377 # PDB 3O86 X-ray; 1.60 A; A/B=20-377 # PDB 3O87 X-ray; 1.78 A; A/B=20-377 # PDB 3O88 X-ray; 1.64 A; A/B=20-377 # PDB 4E3I X-ray; 1.60 A; A/B=20-377 # PDB 4E3J X-ray; 1.80 A; A/B=20-377 # PDB 4E3K X-ray; 1.43 A; A/B=20-377 # PDB 4E3L X-ray; 1.43 A; A/B=20-377 # PDB 4E3M X-ray; 1.44 A; A/B=20-377 # PDB 4E3N X-ray; 1.49 A; A/B=20-377 # PDB 4E3O X-ray; 1.60 A; A/B=20-377 # PDB 4JXG X-ray; 1.65 A; A/B=20-377 # PDB 4JXS X-ray; 1.90 A; A/B=20-377 # PDB 4JXV X-ray; 1.76 A; A/B=20-377 # PDB 4JXW X-ray; 2.30 A; A/B=20-377 # PDB 4KEN X-ray; 1.89 A; B=20-377 # PDB 4KG2 X-ray; 1.89 A; A/B=20-377 # PDB 4KG5 X-ray; 2.11 A; A/B/C/D=20-377 # PDB 4KG6 X-ray; 1.75 A; A/B/C/D=20-377 # PDB 4KZ3 X-ray; 1.67 A; A/B=20-377 # PDB 4KZ4 X-ray; 1.42 A; A/B=20-377 # PDB 4KZ5 X-ray; 1.35 A; A/B=20-377 # PDB 4KZ6 X-ray; 1.68 A; A/B=20-377 # PDB 4KZ7 X-ray; 1.43 A; A/B=20-377 # PDB 4KZ8 X-ray; 2.28 A; A/B=20-377 # PDB 4KZ9 X-ray; 1.72 A; A/B=20-377 # PDB 4KZA X-ray; 1.60 A; A/B=20-377 # PDB 4KZB X-ray; 1.37 A; A/B=20-377 # PDB 4LV0 X-ray; 1.65 A; A/B=20-377 # PDB 4LV1 X-ray; 1.74 A; A/B=20-377 # PDB 4LV2 X-ray; 1.65 A; A/B=20-377 # PDB 4LV3 X-ray; 1.42 A; A/B=20-377 # PDB 4OKP X-ray; 1.37 A; A/B=20-377 # PDB 4OLD X-ray; 1.48 A; A/B=20-377 # PDB 4OLG X-ray; 1.71 A; A/B=20-377 # PIR A01007 QKEC # PROSITE PS00336 BETA_LACTAMASE_C # Pfam PF00144 Beta-lactamase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AMPC_ECOLI Beta-lactamase # RefSeq NP_418574 NC_000913.3 # RefSeq WP_001336292 NZ_LN832404.1 # SIMILARITY Belongs to the class-C beta-lactamase family. {ECO 0000305}. # SUBCELLULAR LOCATION AMPC_ECOLI Periplasm. # SUBUNIT Monomer. {ECO:0000269|PubMed 11478888}. # SUPFAM SSF56601 SSF56601 # eggNOG COG1680 LUCA # eggNOG ENOG41066YJ Bacteria BLAST swissprot:AMPC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AMPC_ECOLI BioCyc ECOL316407:JW4111-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4111-MONOMER BioCyc EcoCyc:EG10040-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10040-MONOMER BioCyc MetaCyc:EG10040-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10040-MONOMER COG COG1680 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1680 COG COG2367 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2367 COG COG2602 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2602 DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/S0022-2836(02)00599-5 http://dx.doi.org/10.1016/S0022-2836(02)00599-5 DOI 10.1021/bi0109358 http://dx.doi.org/10.1021/bi0109358 DOI 10.1021/bi981210f http://dx.doi.org/10.1021/bi981210f DOI 10.1021/ja0288338 http://dx.doi.org/10.1021/ja0288338 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.78.8.4897 http://dx.doi.org/10.1073/pnas.78.8.4897 DOI 10.1073/pnas.79.4.1111 http://dx.doi.org/10.1073/pnas.79.4.1111 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1110/ps.8.11.2330 http://dx.doi.org/10.1110/ps.8.11.2330 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB00456 http://www.drugbank.ca/drugs/DB00456 DrugBank DB01147 http://www.drugbank.ca/drugs/DB01147 EC_number EC:3.5.2.6 http://www.genome.jp/dbget-bin/www_bget?EC:3.5.2.6 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01611 http://www.ebi.ac.uk/ena/data/view/J01611 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL V00277 http://www.ebi.ac.uk/ena/data/view/V00277 ENZYME 3.5.2.6 http://enzyme.expasy.org/EC/3.5.2.6 EchoBASE EB0038 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0038 EcoGene EG10040 http://www.ecogene.org/geneInfo.php?eg_id=EG10040 EnsemblBacteria AAC77110 http://www.ensemblgenomes.org/id/AAC77110 EnsemblBacteria AAC77110 http://www.ensemblgenomes.org/id/AAC77110 EnsemblBacteria BAE78154 http://www.ensemblgenomes.org/id/BAE78154 EnsemblBacteria BAE78154 http://www.ensemblgenomes.org/id/BAE78154 EnsemblBacteria BAE78154 http://www.ensemblgenomes.org/id/BAE78154 EnsemblBacteria b4150 http://www.ensemblgenomes.org/id/b4150 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0008800 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008800 GO_process GO:0017001 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017001 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 3.40.710.10 http://www.cathdb.info/version/latest/superfamily/3.40.710.10 GeneID 948669 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948669 HOGENOM HOG000267102 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267102&db=HOGENOM6 InParanoid P00811 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00811 IntAct P00811 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00811* IntEnz 3.5.2.6 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.2.6 InterPro IPR001466 http://www.ebi.ac.uk/interpro/entry/IPR001466 InterPro IPR001586 http://www.ebi.ac.uk/interpro/entry/IPR001586 InterPro IPR012338 http://www.ebi.ac.uk/interpro/entry/IPR012338 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4111 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4111 KEGG_Gene eco:b4150 http://www.genome.jp/dbget-bin/www_bget?eco:b4150 KEGG_Orthology KO:K01467 http://www.genome.jp/dbget-bin/www_bget?KO:K01467 KEGG_Pathway ko00311 http://www.genome.jp/kegg-bin/show_pathway?ko00311 KEGG_Pathway ko00312 http://www.genome.jp/kegg-bin/show_pathway?ko00312 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 KEGG_Reaction rn:R06363 http://www.genome.jp/dbget-bin/www_bget?rn:R06363 OMA ARPAMEY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ARPAMEY PDB 1C3B http://www.ebi.ac.uk/pdbe-srv/view/entry/1C3B PDB 1FCM http://www.ebi.ac.uk/pdbe-srv/view/entry/1FCM PDB 1FCN http://www.ebi.ac.uk/pdbe-srv/view/entry/1FCN PDB 1FCO http://www.ebi.ac.uk/pdbe-srv/view/entry/1FCO PDB 1FSW http://www.ebi.ac.uk/pdbe-srv/view/entry/1FSW PDB 1FSY http://www.ebi.ac.uk/pdbe-srv/view/entry/1FSY PDB 1GA9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1GA9 PDB 1I5Q http://www.ebi.ac.uk/pdbe-srv/view/entry/1I5Q PDB 1IEL http://www.ebi.ac.uk/pdbe-srv/view/entry/1IEL PDB 1IEM http://www.ebi.ac.uk/pdbe-srv/view/entry/1IEM PDB 1KDS http://www.ebi.ac.uk/pdbe-srv/view/entry/1KDS PDB 1KDW http://www.ebi.ac.uk/pdbe-srv/view/entry/1KDW PDB 1KE0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1KE0 PDB 1KE3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1KE3 PDB 1KE4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1KE4 PDB 1KVL http://www.ebi.ac.uk/pdbe-srv/view/entry/1KVL PDB 1KVM http://www.ebi.ac.uk/pdbe-srv/view/entry/1KVM PDB 1L0D http://www.ebi.ac.uk/pdbe-srv/view/entry/1L0D PDB 1L0E http://www.ebi.ac.uk/pdbe-srv/view/entry/1L0E PDB 1L0F http://www.ebi.ac.uk/pdbe-srv/view/entry/1L0F PDB 1L0G http://www.ebi.ac.uk/pdbe-srv/view/entry/1L0G PDB 1L2S http://www.ebi.ac.uk/pdbe-srv/view/entry/1L2S PDB 1LL5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1LL5 PDB 1LL9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1LL9 PDB 1LLB http://www.ebi.ac.uk/pdbe-srv/view/entry/1LLB PDB 1MXO http://www.ebi.ac.uk/pdbe-srv/view/entry/1MXO PDB 1MY8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1MY8 PDB 1O07 http://www.ebi.ac.uk/pdbe-srv/view/entry/1O07 PDB 1PI4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1PI4 PDB 1PI5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1PI5 PDB 1XGI http://www.ebi.ac.uk/pdbe-srv/view/entry/1XGI PDB 1XGJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1XGJ PDB 2BLS http://www.ebi.ac.uk/pdbe-srv/view/entry/2BLS PDB 2FFY http://www.ebi.ac.uk/pdbe-srv/view/entry/2FFY PDB 2HDQ http://www.ebi.ac.uk/pdbe-srv/view/entry/2HDQ PDB 2HDR http://www.ebi.ac.uk/pdbe-srv/view/entry/2HDR PDB 2HDS http://www.ebi.ac.uk/pdbe-srv/view/entry/2HDS PDB 2HDU http://www.ebi.ac.uk/pdbe-srv/view/entry/2HDU PDB 2I72 http://www.ebi.ac.uk/pdbe-srv/view/entry/2I72 PDB 2P9V http://www.ebi.ac.uk/pdbe-srv/view/entry/2P9V PDB 2PU2 http://www.ebi.ac.uk/pdbe-srv/view/entry/2PU2 PDB 2PU4 http://www.ebi.ac.uk/pdbe-srv/view/entry/2PU4 PDB 2R9W http://www.ebi.ac.uk/pdbe-srv/view/entry/2R9W PDB 2R9X http://www.ebi.ac.uk/pdbe-srv/view/entry/2R9X PDB 2RCX http://www.ebi.ac.uk/pdbe-srv/view/entry/2RCX PDB 3BLS http://www.ebi.ac.uk/pdbe-srv/view/entry/3BLS PDB 3BM6 http://www.ebi.ac.uk/pdbe-srv/view/entry/3BM6 PDB 3FKV http://www.ebi.ac.uk/pdbe-srv/view/entry/3FKV PDB 3FKW http://www.ebi.ac.uk/pdbe-srv/view/entry/3FKW PDB 3GQZ http://www.ebi.ac.uk/pdbe-srv/view/entry/3GQZ PDB 3GR2 http://www.ebi.ac.uk/pdbe-srv/view/entry/3GR2 PDB 3GRJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3GRJ PDB 3GSG http://www.ebi.ac.uk/pdbe-srv/view/entry/3GSG PDB 3GTC http://www.ebi.ac.uk/pdbe-srv/view/entry/3GTC PDB 3GV9 http://www.ebi.ac.uk/pdbe-srv/view/entry/3GV9 PDB 3GVB http://www.ebi.ac.uk/pdbe-srv/view/entry/3GVB PDB 3IWI http://www.ebi.ac.uk/pdbe-srv/view/entry/3IWI PDB 3IWO http://www.ebi.ac.uk/pdbe-srv/view/entry/3IWO PDB 3IWQ http://www.ebi.ac.uk/pdbe-srv/view/entry/3IWQ PDB 3IXB http://www.ebi.ac.uk/pdbe-srv/view/entry/3IXB PDB 3IXD http://www.ebi.ac.uk/pdbe-srv/view/entry/3IXD PDB 3IXG http://www.ebi.ac.uk/pdbe-srv/view/entry/3IXG PDB 3IXH http://www.ebi.ac.uk/pdbe-srv/view/entry/3IXH PDB 3O86 http://www.ebi.ac.uk/pdbe-srv/view/entry/3O86 PDB 3O87 http://www.ebi.ac.uk/pdbe-srv/view/entry/3O87 PDB 3O88 http://www.ebi.ac.uk/pdbe-srv/view/entry/3O88 PDB 4E3I http://www.ebi.ac.uk/pdbe-srv/view/entry/4E3I PDB 4E3J http://www.ebi.ac.uk/pdbe-srv/view/entry/4E3J PDB 4E3K http://www.ebi.ac.uk/pdbe-srv/view/entry/4E3K PDB 4E3L http://www.ebi.ac.uk/pdbe-srv/view/entry/4E3L PDB 4E3M http://www.ebi.ac.uk/pdbe-srv/view/entry/4E3M PDB 4E3N http://www.ebi.ac.uk/pdbe-srv/view/entry/4E3N PDB 4E3O http://www.ebi.ac.uk/pdbe-srv/view/entry/4E3O PDB 4JXG http://www.ebi.ac.uk/pdbe-srv/view/entry/4JXG PDB 4JXS http://www.ebi.ac.uk/pdbe-srv/view/entry/4JXS PDB 4JXV http://www.ebi.ac.uk/pdbe-srv/view/entry/4JXV PDB 4JXW http://www.ebi.ac.uk/pdbe-srv/view/entry/4JXW PDB 4KEN http://www.ebi.ac.uk/pdbe-srv/view/entry/4KEN PDB 4KG2 http://www.ebi.ac.uk/pdbe-srv/view/entry/4KG2 PDB 4KG5 http://www.ebi.ac.uk/pdbe-srv/view/entry/4KG5 PDB 4KG6 http://www.ebi.ac.uk/pdbe-srv/view/entry/4KG6 PDB 4KZ3 http://www.ebi.ac.uk/pdbe-srv/view/entry/4KZ3 PDB 4KZ4 http://www.ebi.ac.uk/pdbe-srv/view/entry/4KZ4 PDB 4KZ5 http://www.ebi.ac.uk/pdbe-srv/view/entry/4KZ5 PDB 4KZ6 http://www.ebi.ac.uk/pdbe-srv/view/entry/4KZ6 PDB 4KZ7 http://www.ebi.ac.uk/pdbe-srv/view/entry/4KZ7 PDB 4KZ8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4KZ8 PDB 4KZ9 http://www.ebi.ac.uk/pdbe-srv/view/entry/4KZ9 PDB 4KZA http://www.ebi.ac.uk/pdbe-srv/view/entry/4KZA PDB 4KZB http://www.ebi.ac.uk/pdbe-srv/view/entry/4KZB PDB 4LV0 http://www.ebi.ac.uk/pdbe-srv/view/entry/4LV0 PDB 4LV1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4LV1 PDB 4LV2 http://www.ebi.ac.uk/pdbe-srv/view/entry/4LV2 PDB 4LV3 http://www.ebi.ac.uk/pdbe-srv/view/entry/4LV3 PDB 4OKP http://www.ebi.ac.uk/pdbe-srv/view/entry/4OKP PDB 4OLD http://www.ebi.ac.uk/pdbe-srv/view/entry/4OLD PDB 4OLG http://www.ebi.ac.uk/pdbe-srv/view/entry/4OLG PDBsum 1C3B http://www.ebi.ac.uk/pdbsum/1C3B PDBsum 1FCM http://www.ebi.ac.uk/pdbsum/1FCM PDBsum 1FCN http://www.ebi.ac.uk/pdbsum/1FCN PDBsum 1FCO http://www.ebi.ac.uk/pdbsum/1FCO PDBsum 1FSW http://www.ebi.ac.uk/pdbsum/1FSW PDBsum 1FSY http://www.ebi.ac.uk/pdbsum/1FSY PDBsum 1GA9 http://www.ebi.ac.uk/pdbsum/1GA9 PDBsum 1I5Q http://www.ebi.ac.uk/pdbsum/1I5Q PDBsum 1IEL http://www.ebi.ac.uk/pdbsum/1IEL PDBsum 1IEM http://www.ebi.ac.uk/pdbsum/1IEM PDBsum 1KDS http://www.ebi.ac.uk/pdbsum/1KDS PDBsum 1KDW http://www.ebi.ac.uk/pdbsum/1KDW PDBsum 1KE0 http://www.ebi.ac.uk/pdbsum/1KE0 PDBsum 1KE3 http://www.ebi.ac.uk/pdbsum/1KE3 PDBsum 1KE4 http://www.ebi.ac.uk/pdbsum/1KE4 PDBsum 1KVL http://www.ebi.ac.uk/pdbsum/1KVL PDBsum 1KVM http://www.ebi.ac.uk/pdbsum/1KVM PDBsum 1L0D http://www.ebi.ac.uk/pdbsum/1L0D PDBsum 1L0E http://www.ebi.ac.uk/pdbsum/1L0E PDBsum 1L0F http://www.ebi.ac.uk/pdbsum/1L0F PDBsum 1L0G http://www.ebi.ac.uk/pdbsum/1L0G PDBsum 1L2S http://www.ebi.ac.uk/pdbsum/1L2S PDBsum 1LL5 http://www.ebi.ac.uk/pdbsum/1LL5 PDBsum 1LL9 http://www.ebi.ac.uk/pdbsum/1LL9 PDBsum 1LLB http://www.ebi.ac.uk/pdbsum/1LLB PDBsum 1MXO http://www.ebi.ac.uk/pdbsum/1MXO PDBsum 1MY8 http://www.ebi.ac.uk/pdbsum/1MY8 PDBsum 1O07 http://www.ebi.ac.uk/pdbsum/1O07 PDBsum 1PI4 http://www.ebi.ac.uk/pdbsum/1PI4 PDBsum 1PI5 http://www.ebi.ac.uk/pdbsum/1PI5 PDBsum 1XGI http://www.ebi.ac.uk/pdbsum/1XGI PDBsum 1XGJ http://www.ebi.ac.uk/pdbsum/1XGJ PDBsum 2BLS http://www.ebi.ac.uk/pdbsum/2BLS PDBsum 2FFY http://www.ebi.ac.uk/pdbsum/2FFY PDBsum 2HDQ http://www.ebi.ac.uk/pdbsum/2HDQ PDBsum 2HDR http://www.ebi.ac.uk/pdbsum/2HDR PDBsum 2HDS http://www.ebi.ac.uk/pdbsum/2HDS PDBsum 2HDU http://www.ebi.ac.uk/pdbsum/2HDU PDBsum 2I72 http://www.ebi.ac.uk/pdbsum/2I72 PDBsum 2P9V http://www.ebi.ac.uk/pdbsum/2P9V PDBsum 2PU2 http://www.ebi.ac.uk/pdbsum/2PU2 PDBsum 2PU4 http://www.ebi.ac.uk/pdbsum/2PU4 PDBsum 2R9W http://www.ebi.ac.uk/pdbsum/2R9W PDBsum 2R9X http://www.ebi.ac.uk/pdbsum/2R9X PDBsum 2RCX http://www.ebi.ac.uk/pdbsum/2RCX PDBsum 3BLS http://www.ebi.ac.uk/pdbsum/3BLS PDBsum 3BM6 http://www.ebi.ac.uk/pdbsum/3BM6 PDBsum 3FKV http://www.ebi.ac.uk/pdbsum/3FKV PDBsum 3FKW http://www.ebi.ac.uk/pdbsum/3FKW PDBsum 3GQZ http://www.ebi.ac.uk/pdbsum/3GQZ PDBsum 3GR2 http://www.ebi.ac.uk/pdbsum/3GR2 PDBsum 3GRJ http://www.ebi.ac.uk/pdbsum/3GRJ PDBsum 3GSG http://www.ebi.ac.uk/pdbsum/3GSG PDBsum 3GTC http://www.ebi.ac.uk/pdbsum/3GTC PDBsum 3GV9 http://www.ebi.ac.uk/pdbsum/3GV9 PDBsum 3GVB http://www.ebi.ac.uk/pdbsum/3GVB PDBsum 3IWI http://www.ebi.ac.uk/pdbsum/3IWI PDBsum 3IWO http://www.ebi.ac.uk/pdbsum/3IWO PDBsum 3IWQ http://www.ebi.ac.uk/pdbsum/3IWQ PDBsum 3IXB http://www.ebi.ac.uk/pdbsum/3IXB PDBsum 3IXD http://www.ebi.ac.uk/pdbsum/3IXD PDBsum 3IXG http://www.ebi.ac.uk/pdbsum/3IXG PDBsum 3IXH http://www.ebi.ac.uk/pdbsum/3IXH PDBsum 3O86 http://www.ebi.ac.uk/pdbsum/3O86 PDBsum 3O87 http://www.ebi.ac.uk/pdbsum/3O87 PDBsum 3O88 http://www.ebi.ac.uk/pdbsum/3O88 PDBsum 4E3I http://www.ebi.ac.uk/pdbsum/4E3I PDBsum 4E3J http://www.ebi.ac.uk/pdbsum/4E3J PDBsum 4E3K http://www.ebi.ac.uk/pdbsum/4E3K PDBsum 4E3L http://www.ebi.ac.uk/pdbsum/4E3L PDBsum 4E3M http://www.ebi.ac.uk/pdbsum/4E3M PDBsum 4E3N http://www.ebi.ac.uk/pdbsum/4E3N PDBsum 4E3O http://www.ebi.ac.uk/pdbsum/4E3O PDBsum 4JXG http://www.ebi.ac.uk/pdbsum/4JXG PDBsum 4JXS http://www.ebi.ac.uk/pdbsum/4JXS PDBsum 4JXV http://www.ebi.ac.uk/pdbsum/4JXV PDBsum 4JXW http://www.ebi.ac.uk/pdbsum/4JXW PDBsum 4KEN http://www.ebi.ac.uk/pdbsum/4KEN PDBsum 4KG2 http://www.ebi.ac.uk/pdbsum/4KG2 PDBsum 4KG5 http://www.ebi.ac.uk/pdbsum/4KG5 PDBsum 4KG6 http://www.ebi.ac.uk/pdbsum/4KG6 PDBsum 4KZ3 http://www.ebi.ac.uk/pdbsum/4KZ3 PDBsum 4KZ4 http://www.ebi.ac.uk/pdbsum/4KZ4 PDBsum 4KZ5 http://www.ebi.ac.uk/pdbsum/4KZ5 PDBsum 4KZ6 http://www.ebi.ac.uk/pdbsum/4KZ6 PDBsum 4KZ7 http://www.ebi.ac.uk/pdbsum/4KZ7 PDBsum 4KZ8 http://www.ebi.ac.uk/pdbsum/4KZ8 PDBsum 4KZ9 http://www.ebi.ac.uk/pdbsum/4KZ9 PDBsum 4KZA http://www.ebi.ac.uk/pdbsum/4KZA PDBsum 4KZB http://www.ebi.ac.uk/pdbsum/4KZB PDBsum 4LV0 http://www.ebi.ac.uk/pdbsum/4LV0 PDBsum 4LV1 http://www.ebi.ac.uk/pdbsum/4LV1 PDBsum 4LV2 http://www.ebi.ac.uk/pdbsum/4LV2 PDBsum 4LV3 http://www.ebi.ac.uk/pdbsum/4LV3 PDBsum 4OKP http://www.ebi.ac.uk/pdbsum/4OKP PDBsum 4OLD http://www.ebi.ac.uk/pdbsum/4OLD PDBsum 4OLG http://www.ebi.ac.uk/pdbsum/4OLG PROSITE PS00336 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00336 PSORT swissprot:AMPC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AMPC_ECOLI PSORT-B swissprot:AMPC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AMPC_ECOLI PSORT2 swissprot:AMPC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AMPC_ECOLI Pfam PF00144 http://pfam.xfam.org/family/PF00144 Phobius swissprot:AMPC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AMPC_ECOLI PhylomeDB P00811 http://phylomedb.org/?seqid=P00811 ProteinModelPortal P00811 http://www.proteinmodelportal.org/query/uniprot/P00811 PubMed 10595535 http://www.ncbi.nlm.nih.gov/pubmed/10595535 PubMed 11478888 http://www.ncbi.nlm.nih.gov/pubmed/11478888 PubMed 12144785 http://www.ncbi.nlm.nih.gov/pubmed/12144785 PubMed 12526668 http://www.ncbi.nlm.nih.gov/pubmed/12526668 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6795623 http://www.ncbi.nlm.nih.gov/pubmed/6795623 PubMed 7041115 http://www.ncbi.nlm.nih.gov/pubmed/7041115 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9819201 http://www.ncbi.nlm.nih.gov/pubmed/9819201 RefSeq NP_418574 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418574 RefSeq WP_001336292 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001336292 SMR P00811 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00811 STRING 511145.b4150 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4150&targetmode=cogs STRING COG1680 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1680&targetmode=cogs STRING COG2367 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2367&targetmode=cogs STRING COG2602 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2602&targetmode=cogs SUPFAM SSF56601 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56601 SWISS-2DPAGE P00811 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P00811 UniProtKB AMPC_ECOLI http://www.uniprot.org/uniprot/AMPC_ECOLI UniProtKB-AC P00811 http://www.uniprot.org/uniprot/P00811 charge swissprot:AMPC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AMPC_ECOLI eggNOG COG1680 http://eggnogapi.embl.de/nog_data/html/tree/COG1680 eggNOG ENOG41066YJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG41066YJ epestfind swissprot:AMPC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AMPC_ECOLI garnier swissprot:AMPC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AMPC_ECOLI helixturnhelix swissprot:AMPC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AMPC_ECOLI hmoment swissprot:AMPC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AMPC_ECOLI iep swissprot:AMPC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AMPC_ECOLI inforesidue swissprot:AMPC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AMPC_ECOLI octanol swissprot:AMPC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AMPC_ECOLI pepcoil swissprot:AMPC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AMPC_ECOLI pepdigest swissprot:AMPC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AMPC_ECOLI pepinfo swissprot:AMPC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AMPC_ECOLI pepnet swissprot:AMPC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AMPC_ECOLI pepstats swissprot:AMPC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AMPC_ECOLI pepwheel swissprot:AMPC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AMPC_ECOLI pepwindow swissprot:AMPC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AMPC_ECOLI sigcleave swissprot:AMPC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AMPC_ECOLI ## Database ID URL or Descriptions # BioGrid 4261738 7 # EcoGene EG13838 ydfZ # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # IntAct P64463 12 # InterPro IPR017704 Se-bd_putative_YdfZ # Organism YDFZ_ECOLI Escherichia coli (strain K12) # PATRIC 32118382 VBIEscCol129921_1611 # PIR H64908 H64908 # Pfam PF14001 YdfZ # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDFZ_ECOLI Putative selenoprotein YdfZ # RefSeq NP_416059 NC_000913.3 # RefSeq WP_000214712 NZ_LN832404.1 # TIGRFAMs TIGR03318 YdfZ_fam # eggNOG ENOG41061EV Bacteria # eggNOG ENOG41126WX LUCA BLAST swissprot:YDFZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDFZ_ECOLI BioCyc ECOL316407:JW1534-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1534-MONOMER BioCyc EcoCyc:G6815-MONOMER http://biocyc.org/getid?id=EcoCyc:G6815-MONOMER DIP DIP-48219N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48219N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.142291199 http://dx.doi.org/10.1073/pnas.142291199 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3599 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3599 EcoGene EG13838 http://www.ecogene.org/geneInfo.php?eg_id=EG13838 EnsemblBacteria AAC74614 http://www.ensemblgenomes.org/id/AAC74614 EnsemblBacteria AAC74614 http://www.ensemblgenomes.org/id/AAC74614 EnsemblBacteria BAE76463 http://www.ensemblgenomes.org/id/BAE76463 EnsemblBacteria BAE76463 http://www.ensemblgenomes.org/id/BAE76463 EnsemblBacteria BAE76463 http://www.ensemblgenomes.org/id/BAE76463 EnsemblBacteria b1541 http://www.ensemblgenomes.org/id/b1541 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GeneID 948796 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948796 HOGENOM HOG000269957 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000269957&db=HOGENOM6 IntAct P64463 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P64463* InterPro IPR017704 http://www.ebi.ac.uk/interpro/entry/IPR017704 KEGG_Gene ecj:JW1534 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1534 KEGG_Gene eco:b1541 http://www.genome.jp/dbget-bin/www_bget?eco:b1541 OMA CEGKFEP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CEGKFEP PSORT swissprot:YDFZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDFZ_ECOLI PSORT-B swissprot:YDFZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDFZ_ECOLI PSORT2 swissprot:YDFZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDFZ_ECOLI Pfam PF14001 http://pfam.xfam.org/family/PF14001 Phobius swissprot:YDFZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDFZ_ECOLI ProteinModelPortal P64463 http://www.proteinmodelportal.org/query/uniprot/P64463 PubMed 12084818 http://www.ncbi.nlm.nih.gov/pubmed/12084818 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416059 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416059 RefSeq WP_000214712 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000214712 STRING 511145.b1541 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1541&targetmode=cogs TIGRFAMs TIGR03318 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03318 UniProtKB YDFZ_ECOLI http://www.uniprot.org/uniprot/YDFZ_ECOLI UniProtKB-AC P64463 http://www.uniprot.org/uniprot/P64463 charge swissprot:YDFZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDFZ_ECOLI eggNOG ENOG41061EV http://eggnogapi.embl.de/nog_data/html/tree/ENOG41061EV eggNOG ENOG41126WX http://eggnogapi.embl.de/nog_data/html/tree/ENOG41126WX epestfind swissprot:YDFZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDFZ_ECOLI garnier swissprot:YDFZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDFZ_ECOLI helixturnhelix swissprot:YDFZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDFZ_ECOLI hmoment swissprot:YDFZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDFZ_ECOLI iep swissprot:YDFZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDFZ_ECOLI inforesidue swissprot:YDFZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDFZ_ECOLI octanol swissprot:YDFZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDFZ_ECOLI pepcoil swissprot:YDFZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDFZ_ECOLI pepdigest swissprot:YDFZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDFZ_ECOLI pepinfo swissprot:YDFZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDFZ_ECOLI pepnet swissprot:YDFZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDFZ_ECOLI pepstats swissprot:YDFZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDFZ_ECOLI pepwheel swissprot:YDFZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDFZ_ECOLI pepwindow swissprot:YDFZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDFZ_ECOLI sigcleave swissprot:YDFZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDFZ_ECOLI ## Database ID URL or Descriptions # AltName PNTA_ECOLI Nicotinamide nucleotide transhydrogenase subunit alpha # AltName PNTA_ECOLI Pyridine nucleotide transhydrogenase subunit alpha # BRENDA 1.6.1 2026 # BioGrid 4260811 6 # CATALYTIC ACTIVITY NADPH + NAD(+) = NADP(+) + NADH. {ECO:0000269|PubMed 16083909}. # EcoGene EG10744 pntA # FUNCTION PNTA_ECOLI The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:UniProtKB. # GO_function GO:0008750 NAD(P)+ transhydrogenase (AB-specific) activity; IDA:UniProtKB. # GO_function GO:0046983 protein dimerization activity; IDA:UniProtKB. # GO_function GO:0050661 NADP binding; IBA:GO_Central. # GO_function GO:0051287 NAD binding; IDA:EcoCyc. # GO_process GO:0006740 NADPH regeneration; IDA:UniProtKB. # GO_process GO:0015992 proton transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006810 transport # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.50.50.60 -; 1. # IntAct P07001 2 # InterPro IPR007698 AlaDH/PNT_NAD(H)-bd # InterPro IPR007886 AlaDH/PNT_N # InterPro IPR008142 AlaDH/PNT_CS1 # InterPro IPR008143 Ala_DH/PNT_CS2 # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR023753 FAD/NAD-binding_dom # InterPro IPR024605 NADP_transhyd_a_C # InterPro IPR026255 NADP_transhyd_a # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00760 Nicotinate and nicotinamide metabolism # Organism PNTA_ECOLI Escherichia coli (strain K12) # PATRIC 32118508 VBIEscCol129921_1674 # PDB 1X13 X-ray; 1.90 A; A/B=2-394 # PDB 1X14 X-ray; 1.94 A; A/B=2-394 # PDB 1X15 X-ray; 2.04 A; A/B=2-394 # PDB 2BRU NMR; -; A/B=2-394 # PIR S24380 DEECXA # PIRSF PIRSF000203 NADP_transhydrogenase_alpha # PROSITE PS00836 ALADH_PNT_1 # PROSITE PS00837 ALADH_PNT_2 # Pfam PF01262 AlaDh_PNT_C # Pfam PF05222 AlaDh_PNT_N # Pfam PF12769 PNTB_4TM # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PNTA_ECOLI NAD(P) transhydrogenase subunit alpha # RefSeq NP_416120 NC_000913.3 # RefSeq WP_001300486 NZ_LN832404.1 # SIMILARITY Belongs to the AlaDH/PNT family. {ECO 0000305}. # SMART SM01002 AlaDh_PNT_C # SMART SM01003 AlaDh_PNT_N # SUBCELLULAR LOCATION PNTA_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT Heterodimer of an alpha (PntA) and a beta (PntB) chain. Alpha subunit serves as the dimerization unit. {ECO:0000269|PubMed 16083909, ECO:0000269|Ref.9}. # SUPFAM SSF51735 SSF51735 # TCDB 3.D.2.1 the proton-translocating transhydrogenase (pth) family # TIGRFAMs TIGR00561 pntA # eggNOG COG3288 LUCA # eggNOG ENOG4108IIE Bacteria BLAST swissprot:PNTA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PNTA_ECOLI BioCyc ECOL316407:JW1595-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1595-MONOMER BioCyc EcoCyc:PNTA-MONOMER http://biocyc.org/getid?id=EcoCyc:PNTA-MONOMER BioCyc MetaCyc:PNTA-MONOMER http://biocyc.org/getid?id=MetaCyc:PNTA-MONOMER COG COG3288 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3288 DIP DIP-366N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-366N DOI 10.1016/0167-4838(91)90106-A http://dx.doi.org/10.1016/0167-4838(91)90106-A DOI 10.1016/j.jmb.2005.07.022 http://dx.doi.org/10.1016/j.jmb.2005.07.022 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1111/j.1432-1033.1986.tb09802.x http://dx.doi.org/10.1111/j.1432-1033.1986.tb09802.x DOI 10.1111/j.1432-1033.1992.tb17103.x http://dx.doi.org/10.1111/j.1432-1033.1992.tb17103.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.6.1.2 http://www.genome.jp/dbget-bin/www_bget?EC:1.6.1.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X04195 http://www.ebi.ac.uk/ena/data/view/X04195 EMBL X66086 http://www.ebi.ac.uk/ena/data/view/X66086 ENZYME 1.6.1.2 http://enzyme.expasy.org/EC/1.6.1.2 EchoBASE EB0737 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0737 EcoGene EG10744 http://www.ecogene.org/geneInfo.php?eg_id=EG10744 EnsemblBacteria AAC74675 http://www.ensemblgenomes.org/id/AAC74675 EnsemblBacteria AAC74675 http://www.ensemblgenomes.org/id/AAC74675 EnsemblBacteria BAA15342 http://www.ensemblgenomes.org/id/BAA15342 EnsemblBacteria BAA15342 http://www.ensemblgenomes.org/id/BAA15342 EnsemblBacteria BAA15342 http://www.ensemblgenomes.org/id/BAA15342 EnsemblBacteria b1603 http://www.ensemblgenomes.org/id/b1603 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0008750 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008750 GO_function GO:0046983 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046983 GO_function GO:0050661 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050661 GO_function GO:0051287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051287 GO_process GO:0006740 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006740 GO_process GO:0015992 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015992 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 GeneID 946628 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946628 HOGENOM HOG000022121 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000022121&db=HOGENOM6 InParanoid P07001 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P07001 IntAct P07001 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P07001* IntEnz 1.6.1.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.6.1.2 InterPro IPR007698 http://www.ebi.ac.uk/interpro/entry/IPR007698 InterPro IPR007886 http://www.ebi.ac.uk/interpro/entry/IPR007886 InterPro IPR008142 http://www.ebi.ac.uk/interpro/entry/IPR008142 InterPro IPR008143 http://www.ebi.ac.uk/interpro/entry/IPR008143 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 InterPro IPR024605 http://www.ebi.ac.uk/interpro/entry/IPR024605 InterPro IPR026255 http://www.ebi.ac.uk/interpro/entry/IPR026255 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1595 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1595 KEGG_Gene eco:b1603 http://www.genome.jp/dbget-bin/www_bget?eco:b1603 KEGG_Orthology KO:K00324 http://www.genome.jp/dbget-bin/www_bget?KO:K00324 KEGG_Pathway ko00760 http://www.genome.jp/kegg-bin/show_pathway?ko00760 KEGG_Reaction rn:R00112 http://www.genome.jp/dbget-bin/www_bget?rn:R00112 MINT MINT-1299705 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1299705 OMA NVAPKEF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NVAPKEF PDB 1X13 http://www.ebi.ac.uk/pdbe-srv/view/entry/1X13 PDB 1X14 http://www.ebi.ac.uk/pdbe-srv/view/entry/1X14 PDB 1X15 http://www.ebi.ac.uk/pdbe-srv/view/entry/1X15 PDB 2BRU http://www.ebi.ac.uk/pdbe-srv/view/entry/2BRU PDBsum 1X13 http://www.ebi.ac.uk/pdbsum/1X13 PDBsum 1X14 http://www.ebi.ac.uk/pdbsum/1X14 PDBsum 1X15 http://www.ebi.ac.uk/pdbsum/1X15 PDBsum 2BRU http://www.ebi.ac.uk/pdbsum/2BRU PROSITE PS00836 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00836 PROSITE PS00837 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00837 PSORT swissprot:PNTA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PNTA_ECOLI PSORT-B swissprot:PNTA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PNTA_ECOLI PSORT2 swissprot:PNTA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PNTA_ECOLI Pfam PF01262 http://pfam.xfam.org/family/PF01262 Pfam PF05222 http://pfam.xfam.org/family/PF05222 Pfam PF12769 http://pfam.xfam.org/family/PF12769 Phobius swissprot:PNTA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PNTA_ECOLI PhylomeDB P07001 http://phylomedb.org/?seqid=P07001 ProteinModelPortal P07001 http://www.proteinmodelportal.org/query/uniprot/P07001 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16083909 http://www.ncbi.nlm.nih.gov/pubmed/16083909 PubMed 1633824 http://www.ncbi.nlm.nih.gov/pubmed/1633824 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1932078 http://www.ncbi.nlm.nih.gov/pubmed/1932078 PubMed 3525165 http://www.ncbi.nlm.nih.gov/pubmed/3525165 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416120 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416120 RefSeq WP_001300486 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300486 SMART SM01002 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01002 SMART SM01003 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01003 SMR P07001 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P07001 STRING 511145.b1603 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1603&targetmode=cogs STRING COG3288 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3288&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 TCDB 3.D.2.1 http://www.tcdb.org/search/result.php?tc=3.D.2.1 TIGRFAMs TIGR00561 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00561 UniProtKB PNTA_ECOLI http://www.uniprot.org/uniprot/PNTA_ECOLI UniProtKB-AC P07001 http://www.uniprot.org/uniprot/P07001 charge swissprot:PNTA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PNTA_ECOLI eggNOG COG3288 http://eggnogapi.embl.de/nog_data/html/tree/COG3288 eggNOG ENOG4108IIE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108IIE epestfind swissprot:PNTA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PNTA_ECOLI garnier swissprot:PNTA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PNTA_ECOLI helixturnhelix swissprot:PNTA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PNTA_ECOLI hmoment swissprot:PNTA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PNTA_ECOLI iep swissprot:PNTA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PNTA_ECOLI inforesidue swissprot:PNTA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PNTA_ECOLI octanol swissprot:PNTA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PNTA_ECOLI pepcoil swissprot:PNTA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PNTA_ECOLI pepdigest swissprot:PNTA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PNTA_ECOLI pepinfo swissprot:PNTA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PNTA_ECOLI pepnet swissprot:PNTA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PNTA_ECOLI pepstats swissprot:PNTA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PNTA_ECOLI pepwheel swissprot:PNTA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PNTA_ECOLI pepwindow swissprot:PNTA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PNTA_ECOLI sigcleave swissprot:PNTA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PNTA_ECOLI ## Database ID URL or Descriptions # AltName LPLA_ECOLI Lipoate--protein ligase # BIOPHYSICOCHEMICAL PROPERTIES LPLA_ECOLI Kinetic parameters KM=1.9 uM for ATP {ECO 0000269|PubMed 7639702}; KM=1.7 uM for D,L-lipoic acid {ECO 0000269|PubMed 7639702}; KM=152 uM for magnesium ion {ECO 0000269|PubMed 7639702}; Vmax=40 nmol/min/mg enzyme toward ATP {ECO 0000269|PubMed 7639702}; Vmax=24 nmol/min/mg enzyme toward D,L-lipoic acid {ECO 0000269|PubMed 7639702}; pH dependence Most active from pH 5.5 to 8.0. Inactive below pH 4.3. {ECO 0000269|PubMed 7639702}; # BRENDA 2.7.7.63 2026 # BioGrid 4262787 9 # CATALYTIC ACTIVITY LPLA_ECOLI ATP + (R)-lipoate + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N(6)-(lipoyl)lysine + AMP + diphosphate. # ENZYME REGULATION LPLA_ECOLI 6-seleno-octanoate, 8-thio-octanoate and 8- seleno-octanoate caused 100%, 50% and 63% inhibition respectively. Inhibited by Cu(2+). # EcoGene EG11796 lplA # FUNCTION LPLA_ECOLI Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes. Is also able to catalyze very poorly the transfer of lipoyl and octanoyl moiety from their acyl carrier protein. {ECO 0000269|PubMed 7639702}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016979 lipoate-protein ligase activity; IDA:EcoCyc. # GO_function GO:0017118 lipoyltransferase activity; IBA:GO_Central. # GO_process GO:0009249 protein lipoylation; IMP:EcoCyc. # GO_process GO:0018055 peptidyl-lysine lipoylation; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # HAMAP MF_01602 LplA # IntAct P32099 3 # InterPro IPR004143 BPL_LPL_catalytic # InterPro IPR004562 LipoylTrfase_LipoateP_Ligase # InterPro IPR019491 Lipoate_protein_ligase_C # InterPro IPR023741 Lipoate_ligase_A # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00785 Lipoic acid metabolism # MISCELLANEOUS LPLA_ECOLI In the transfer reaction, the free carboxyl group of lipoic acid is attached via an amide linkage to the epsilon- amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes. # Organism LPLA_ECOLI Escherichia coli (strain K12) # PATHWAY Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate step 1/2. # PATHWAY Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate step 2/2. # PATRIC 32124388 VBIEscCol129921_4534 # PDB 1X2G X-ray; 2.40 A; A/B/C=2-338 # PDB 1X2H X-ray; 2.91 A; A/B/C=2-338 # PDB 3A7A X-ray; 3.10 A; A/C=2-338 # PDB 3A7R X-ray; 2.05 A; A=2-338 # PDB 4TVW X-ray; 3.50 A; A/B/C/D=1-338 # PDB 4TVY X-ray; 2.15 A; A/B=1-338 # PIR A54035 A54035 # PROSITE PS51733 BPL_LPL_CATALYTIC # Pfam PF03099 BPL_LplA_LipB # Pfam PF10437 Lip_prot_lig_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LPLA_ECOLI Lipoate-protein ligase A # RefSeq NP_418803 NC_000913.3 # RefSeq WP_000105884 NZ_LN832404.1 # SIMILARITY Belongs to the LplA family. {ECO 0000305}. # SIMILARITY Contains 1 BPL/LPL catalytic domain. {ECO:0000255|PROSITE-ProRule PRU01067}. # SUBCELLULAR LOCATION LPLA_ECOLI Cytoplasm. # SUBUNIT Monomer. {ECO:0000269|PubMed 7639702}. # TIGRFAMs TIGR00545 lipoyltrans # UniPathway UPA00537 UER00594 # UniPathway UPA00537 UER00595 # eggNOG COG0095 LUCA # eggNOG ENOG4107RMF Bacteria BLAST swissprot:LPLA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LPLA_ECOLI BioCyc ECOL316407:JW4349-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4349-MONOMER BioCyc EcoCyc:EG11796-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11796-MONOMER BioCyc MetaCyc:EG11796-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11796-MONOMER COG COG0095 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0095 DIP DIP-10119N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10119N DOI 10.1002/path.1711770102 http://dx.doi.org/10.1002/path.1711770102 DOI 10.1016/0378-1119(89)90047-4 http://dx.doi.org/10.1016/0378-1119(89)90047-4 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj3090853 http://dx.doi.org/10.1042/bj3090853 DOI 10.1074/jbc.M505010200 http://dx.doi.org/10.1074/jbc.M505010200 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.185.5.1582-1589.2003 http://dx.doi.org/10.1128/JB.185.5.1582-1589.2003 EC_number EC:6.3.1.20 http://www.genome.jp/dbget-bin/www_bget?EC:6.3.1.20 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L27665 http://www.ebi.ac.uk/ena/data/view/L27665 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X03046 http://www.ebi.ac.uk/ena/data/view/X03046 ENZYME 6.3.1.20 http://enzyme.expasy.org/EC/6.3.1.20 EchoBASE EB1744 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1744 EcoGene EG11796 http://www.ecogene.org/geneInfo.php?eg_id=EG11796 EnsemblBacteria AAC77339 http://www.ensemblgenomes.org/id/AAC77339 EnsemblBacteria AAC77339 http://www.ensemblgenomes.org/id/AAC77339 EnsemblBacteria BAE78375 http://www.ensemblgenomes.org/id/BAE78375 EnsemblBacteria BAE78375 http://www.ensemblgenomes.org/id/BAE78375 EnsemblBacteria BAE78375 http://www.ensemblgenomes.org/id/BAE78375 EnsemblBacteria b4386 http://www.ensemblgenomes.org/id/b4386 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016979 GO_function GO:0017118 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017118 GO_process GO:0009249 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009249 GO_process GO:0018055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018055 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GeneID 944865 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944865 HAMAP MF_01602 http://hamap.expasy.org/unirule/MF_01602 HOGENOM HOG000260594 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260594&db=HOGENOM6 InParanoid P32099 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32099 IntAct P32099 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32099* IntEnz 6.3.1.20 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.1.20 InterPro IPR004143 http://www.ebi.ac.uk/interpro/entry/IPR004143 InterPro IPR004562 http://www.ebi.ac.uk/interpro/entry/IPR004562 InterPro IPR019491 http://www.ebi.ac.uk/interpro/entry/IPR019491 InterPro IPR023741 http://www.ebi.ac.uk/interpro/entry/IPR023741 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4349 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4349 KEGG_Gene eco:b4386 http://www.genome.jp/dbget-bin/www_bget?eco:b4386 KEGG_Orthology KO:K03800 http://www.genome.jp/dbget-bin/www_bget?KO:K03800 KEGG_Pathway ko00785 http://www.genome.jp/kegg-bin/show_pathway?ko00785 KEGG_Reaction rn:R07770 http://www.genome.jp/dbget-bin/www_bget?rn:R07770 KEGG_Reaction rn:R07771 http://www.genome.jp/dbget-bin/www_bget?rn:R07771 MINT MINT-1288545 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1288545 OMA WRNAETV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WRNAETV PDB 1X2G http://www.ebi.ac.uk/pdbe-srv/view/entry/1X2G PDB 1X2H http://www.ebi.ac.uk/pdbe-srv/view/entry/1X2H PDB 3A7A http://www.ebi.ac.uk/pdbe-srv/view/entry/3A7A PDB 3A7R http://www.ebi.ac.uk/pdbe-srv/view/entry/3A7R PDB 4TVW http://www.ebi.ac.uk/pdbe-srv/view/entry/4TVW PDB 4TVY http://www.ebi.ac.uk/pdbe-srv/view/entry/4TVY PDBsum 1X2G http://www.ebi.ac.uk/pdbsum/1X2G PDBsum 1X2H http://www.ebi.ac.uk/pdbsum/1X2H PDBsum 3A7A http://www.ebi.ac.uk/pdbsum/3A7A PDBsum 3A7R http://www.ebi.ac.uk/pdbsum/3A7R PDBsum 4TVW http://www.ebi.ac.uk/pdbsum/4TVW PDBsum 4TVY http://www.ebi.ac.uk/pdbsum/4TVY PROSITE PS51733 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51733 PSORT swissprot:LPLA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LPLA_ECOLI PSORT-B swissprot:LPLA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LPLA_ECOLI PSORT2 swissprot:LPLA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LPLA_ECOLI Pfam PF03099 http://pfam.xfam.org/family/PF03099 Pfam PF10437 http://pfam.xfam.org/family/PF10437 Phobius swissprot:LPLA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LPLA_ECOLI PhylomeDB P32099 http://phylomedb.org/?seqid=P32099 ProteinModelPortal P32099 http://www.proteinmodelportal.org/query/uniprot/P32099 PubMed 12591875 http://www.ncbi.nlm.nih.gov/pubmed/12591875 PubMed 16043486 http://www.ncbi.nlm.nih.gov/pubmed/16043486 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2684780 http://www.ncbi.nlm.nih.gov/pubmed/2684780 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 7639702 http://www.ncbi.nlm.nih.gov/pubmed/7639702 PubMed 8002607 http://www.ncbi.nlm.nih.gov/pubmed/8002607 PubMed 8206909 http://www.ncbi.nlm.nih.gov/pubmed/8206909 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418803 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418803 RefSeq WP_000105884 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000105884 SMR P32099 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32099 STRING 511145.b4386 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4386&targetmode=cogs STRING COG0095 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0095&targetmode=cogs TIGRFAMs TIGR00545 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00545 UniProtKB LPLA_ECOLI http://www.uniprot.org/uniprot/LPLA_ECOLI UniProtKB-AC P32099 http://www.uniprot.org/uniprot/P32099 charge swissprot:LPLA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LPLA_ECOLI eggNOG COG0095 http://eggnogapi.embl.de/nog_data/html/tree/COG0095 eggNOG ENOG4107RMF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107RMF epestfind swissprot:LPLA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LPLA_ECOLI garnier swissprot:LPLA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LPLA_ECOLI helixturnhelix swissprot:LPLA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LPLA_ECOLI hmoment swissprot:LPLA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LPLA_ECOLI iep swissprot:LPLA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LPLA_ECOLI inforesidue swissprot:LPLA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LPLA_ECOLI octanol swissprot:LPLA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LPLA_ECOLI pepcoil swissprot:LPLA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LPLA_ECOLI pepdigest swissprot:LPLA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LPLA_ECOLI pepinfo swissprot:LPLA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LPLA_ECOLI pepnet swissprot:LPLA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LPLA_ECOLI pepstats swissprot:LPLA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LPLA_ECOLI pepwheel swissprot:LPLA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LPLA_ECOLI pepwindow swissprot:LPLA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LPLA_ECOLI sigcleave swissprot:LPLA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LPLA_ECOLI ## Database ID URL or Descriptions # AltName RLMKL_ECOLI rRNA (guanine-N(2)-)-methyltransferase RlmL # AltName RLMKL_ECOLI rRNA (guanine-N(2)-)-methyltransferase RlmL # AltName RLMKL_ECOLI rRNA (guanine-N(7)-)-methyltransferase RlmK # BRENDA 2.1.1.173 2026 # BioGrid 4260025 122 # CATALYTIC ACTIVITY RLMKL_ECOLI S-adenosyl-L-methionine + guanine(2069) in 23S rRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(2069) in 23S rRNA. # CATALYTIC ACTIVITY RLMKL_ECOLI S-adenosyl-L-methionine + guanine(2445) in 23S rRNA = S-adenosyl-L-homocysteine + N(2)-methylguanine(2445) in 23S rRNA. # DOMAIN RLMKL_ECOLI Consists of a N-terminal RlmL domain and a C-terminal RlmK domain, linked by a highly flexible loop. {ECO 0000269|PubMed 22210896, ECO 0000269|PubMed 22362734}. # ENZYME REGULATION The N-terminal RlmL activity is enhanced by the C-terminal RlmK activity. {ECO:0000269|PubMed 22210896}. # EcoGene EG13717 rlmL # FUNCTION RLMKL_ECOLI Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Methylation occurs before assembly of 23S rRNA into 50S subunits. {ECO 0000269|PubMed 17010378, ECO 0000269|PubMed 22210896, ECO 0000269|PubMed 22362734}. # GO_component GO:0005737 cytoplasm; IC:UniProtKB. # GO_function GO:0003723 RNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008990 rRNA (guanine-N2-)-methyltransferase activity; IDA:UniProtKB. # GO_function GO:0052915 23S rRNA (guanine(2445)-N(2))-methyltransferase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0070043 rRNA (guanine-N7-)-methyltransferase activity; IDA:EcoCyc. # GO_process GO:0031167 rRNA methylation; IDA:UniProtKB. # GO_process GO:0070475 rRNA base methylation; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.50.150 -; 3. # HAMAP MF_01858 23SrRNA_methyltr_KL # INTERACTION RLMKL_ECOLI P32132 typA; NbExp=3; IntAct=EBI-547718, EBI-562154; # IntAct P75864 48 # InterPro IPR000241 RNA_methylase_dom # InterPro IPR002052 DNA_methylase_N6_adenine_CS # InterPro IPR004114 THUMP_dom # InterPro IPR017244 23SrRNA_methyltr_KL # InterPro IPR019614 SAM-dep_methyl-trfase # InterPro IPR029063 SAM-dependent_MTases # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # Organism RLMKL_ECOLI Escherichia coli (strain K12) # PATRIC 32117115 VBIEscCol129921_0982 # PDB 3V8V X-ray; 2.60 A; A/B=1-702 # PDB 3V97 X-ray; 2.20 A; A/B=1-702 # PIR C64835 C64835 # PIRSF PIRSF037618 RNA_Mtase_bacteria_prd # PROSITE PS01261 UPF0020 # PROSITE PS51165 THUMP # Pfam PF01170 UPF0020 # Pfam PF02926 THUMP # Pfam PF10672 Methyltrans_SAM # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RLMKL_ECOLI 23S rRNA m2G2445 methyltransferase # RecName RLMKL_ECOLI 23S rRNA m7G2069 methyltransferase # RecName RLMKL_ECOLI Ribosomal RNA large subunit methyltransferase K/L # RecName RLMKL_ECOLI Ribosomal RNA large subunit methyltransferase K/L # RefSeq NP_415468 NC_000913.3 # RefSeq WP_001086539 NZ_LN832404.1 # SIMILARITY Belongs to the methyltransferase superfamily. RlmKL family. {ECO 0000305}. # SIMILARITY Contains 1 THUMP domain. {ECO 0000305}. # SMART SM00981 THUMP # SUBCELLULAR LOCATION RLMKL_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Monomer. {ECO:0000269|PubMed 22362734}. # SUPFAM SSF53335 SSF53335; 3 # eggNOG COG0116 LUCA # eggNOG COG1092 LUCA # eggNOG ENOG4105C4H Bacteria BLAST swissprot:RLMKL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RLMKL_ECOLI BioCyc ECOL316407:JW0931-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0931-MONOMER BioCyc EcoCyc:G6488-MONOMER http://biocyc.org/getid?id=EcoCyc:G6488-MONOMER BioCyc MetaCyc:G6488-MONOMER http://biocyc.org/getid?id=MetaCyc:G6488-MONOMER COG COG0116 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0116 COG COG1092 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1092 DIP DIP-11486N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11486N DOI 10.1016/j.jmb.2006.09.009 http://dx.doi.org/10.1016/j.jmb.2006.09.009 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/gkr1287 http://dx.doi.org/10.1093/nar/gkr1287 DOI 10.1093/nar/gks160 http://dx.doi.org/10.1093/nar/gks160 DOI 10.1107/S1744309110035074 http://dx.doi.org/10.1107/S1744309110035074 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.1.173 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.173 EC_number EC:2.1.1.264 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.264 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.1.1.173 http://enzyme.expasy.org/EC/2.1.1.173 ENZYME 2.1.1.264 http://enzyme.expasy.org/EC/2.1.1.264 EchoBASE EB3481 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3481 EcoGene EG13717 http://www.ecogene.org/geneInfo.php?eg_id=EG13717 EnsemblBacteria AAC74034 http://www.ensemblgenomes.org/id/AAC74034 EnsemblBacteria AAC74034 http://www.ensemblgenomes.org/id/AAC74034 EnsemblBacteria BAA35703 http://www.ensemblgenomes.org/id/BAA35703 EnsemblBacteria BAA35703 http://www.ensemblgenomes.org/id/BAA35703 EnsemblBacteria BAA35703 http://www.ensemblgenomes.org/id/BAA35703 EnsemblBacteria b0948 http://www.ensemblgenomes.org/id/b0948 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0008990 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008990 GO_function GO:0052915 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052915 GO_function GO:0070043 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070043 GO_process GO:0031167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031167 GO_process GO:0070475 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070475 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 GeneID 945564 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945564 HAMAP MF_01858 http://hamap.expasy.org/unirule/MF_01858 HOGENOM HOG000218371 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218371&db=HOGENOM6 InParanoid P75864 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75864 IntAct P75864 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75864* IntEnz 2.1.1.173 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.173 IntEnz 2.1.1.264 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.264 InterPro IPR000241 http://www.ebi.ac.uk/interpro/entry/IPR000241 InterPro IPR002052 http://www.ebi.ac.uk/interpro/entry/IPR002052 InterPro IPR004114 http://www.ebi.ac.uk/interpro/entry/IPR004114 InterPro IPR017244 http://www.ebi.ac.uk/interpro/entry/IPR017244 InterPro IPR019614 http://www.ebi.ac.uk/interpro/entry/IPR019614 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW0931 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0931 KEGG_Gene eco:b0948 http://www.genome.jp/dbget-bin/www_bget?eco:b0948 KEGG_Orthology KO:K12297 http://www.genome.jp/dbget-bin/www_bget?KO:K12297 KEGG_Reaction rn:R07234 http://www.genome.jp/dbget-bin/www_bget?rn:R07234 MINT MINT-1268879 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1268879 OMA MSNTYLN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MSNTYLN PDB 3V8V http://www.ebi.ac.uk/pdbe-srv/view/entry/3V8V PDB 3V97 http://www.ebi.ac.uk/pdbe-srv/view/entry/3V97 PDBsum 3V8V http://www.ebi.ac.uk/pdbsum/3V8V PDBsum 3V97 http://www.ebi.ac.uk/pdbsum/3V97 PROSITE PS01261 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01261 PROSITE PS51165 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51165 PSORT swissprot:RLMKL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RLMKL_ECOLI PSORT-B swissprot:RLMKL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RLMKL_ECOLI PSORT2 swissprot:RLMKL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RLMKL_ECOLI Pfam PF01170 http://pfam.xfam.org/family/PF01170 Pfam PF02926 http://pfam.xfam.org/family/PF02926 Pfam PF10672 http://pfam.xfam.org/family/PF10672 Phobius swissprot:RLMKL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RLMKL_ECOLI PhylomeDB P75864 http://phylomedb.org/?seqid=P75864 ProteinModelPortal P75864 http://www.proteinmodelportal.org/query/uniprot/P75864 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17010378 http://www.ncbi.nlm.nih.gov/pubmed/17010378 PubMed 21045301 http://www.ncbi.nlm.nih.gov/pubmed/21045301 PubMed 22210896 http://www.ncbi.nlm.nih.gov/pubmed/22210896 PubMed 22362734 http://www.ncbi.nlm.nih.gov/pubmed/22362734 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415468 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415468 RefSeq WP_001086539 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001086539 SMART SM00981 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00981 SMR P75864 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75864 STRING 511145.b0948 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0948&targetmode=cogs STRING COG0116 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0116&targetmode=cogs STRING COG1092 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1092&targetmode=cogs SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 UniProtKB RLMKL_ECOLI http://www.uniprot.org/uniprot/RLMKL_ECOLI UniProtKB-AC P75864 http://www.uniprot.org/uniprot/P75864 charge swissprot:RLMKL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RLMKL_ECOLI eggNOG COG0116 http://eggnogapi.embl.de/nog_data/html/tree/COG0116 eggNOG COG1092 http://eggnogapi.embl.de/nog_data/html/tree/COG1092 eggNOG ENOG4105C4H http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C4H epestfind swissprot:RLMKL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RLMKL_ECOLI garnier swissprot:RLMKL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RLMKL_ECOLI helixturnhelix swissprot:RLMKL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RLMKL_ECOLI hmoment swissprot:RLMKL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RLMKL_ECOLI iep swissprot:RLMKL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RLMKL_ECOLI inforesidue swissprot:RLMKL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RLMKL_ECOLI octanol swissprot:RLMKL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RLMKL_ECOLI pepcoil swissprot:RLMKL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RLMKL_ECOLI pepdigest swissprot:RLMKL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RLMKL_ECOLI pepinfo swissprot:RLMKL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RLMKL_ECOLI pepnet swissprot:RLMKL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RLMKL_ECOLI pepstats swissprot:RLMKL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RLMKL_ECOLI pepwheel swissprot:RLMKL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RLMKL_ECOLI pepwindow swissprot:RLMKL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RLMKL_ECOLI sigcleave swissprot:RLMKL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RLMKL_ECOLI ## Database ID URL or Descriptions # BioGrid 4260062 9 # DISRUPTION PHENOTYPE Mutants show no swarming ability. {ECO:0000269|PubMed 21965574}. # EcoGene EG13871 ycdY # FUNCTION YCDY_ECOLI Acts as a chaperone that increases YcdX activity, maybe by facilitating the correct insertion of the zinc ions into the catalytic site of YcdX. Involved in the swarming motility process. {ECO 0000269|PubMed 21965574}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0071978 bacterial-type flagellum-dependent swarming motility; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_process GO:0006950 response to stress # GOslim_process GO:0048870 cell motility # Gene3D 1.10.3480.10 -; 1. # INTERACTION YCDY_ECOLI P75914 ycdX; NbExp=2; IntAct=EBI-1121634, EBI-1121626; # IntAct P75915 7 # InterPro IPR020945 DMSO/NO3_reduct_chaperone # InterPro IPR026269 DmsD-type # MISCELLANEOUS YCDY_ECOLI Does not bind zinc. # Organism YCDY_ECOLI Escherichia coli (strain K12) # PATRIC 32117301 VBIEscCol129921_1073 # PIR H64845 H64845 # PIRSF PIRSF004690 DmsD # Pfam PF02613 Nitrate_red_del # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCDY_ECOLI Chaperone protein YcdY # RefSeq NP_415553 NC_000913.3 # RefSeq WP_001001921 NZ_LN832404.1 # SIMILARITY Belongs to the TorD/DmsD family. {ECO 0000305}. # SUBUNIT Interacts with YcdX. {ECO:0000269|PubMed 21965574}. # SUPFAM SSF89155 SSF89155 # eggNOG COG3381 LUCA # eggNOG ENOG4107XHZ Bacteria BLAST swissprot:YCDY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCDY_ECOLI BioCyc ECOL316407:JW1018-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1018-MONOMER BioCyc EcoCyc:G6541-MONOMER http://biocyc.org/getid?id=EcoCyc:G6541-MONOMER DIP DIP-11519N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11519N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.05927-11 http://dx.doi.org/10.1128/JB.05927-11 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3630 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3630 EcoGene EG13871 http://www.ecogene.org/geneInfo.php?eg_id=EG13871 EnsemblBacteria AAC74119 http://www.ensemblgenomes.org/id/AAC74119 EnsemblBacteria AAC74119 http://www.ensemblgenomes.org/id/AAC74119 EnsemblBacteria BAA35816 http://www.ensemblgenomes.org/id/BAA35816 EnsemblBacteria BAA35816 http://www.ensemblgenomes.org/id/BAA35816 EnsemblBacteria BAA35816 http://www.ensemblgenomes.org/id/BAA35816 EnsemblBacteria b1035 http://www.ensemblgenomes.org/id/b1035 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0071978 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071978 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 Gene3D 1.10.3480.10 http://www.cathdb.info/version/latest/superfamily/1.10.3480.10 GeneID 945609 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945609 HOGENOM HOG000118928 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118928&db=HOGENOM6 InParanoid P75915 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75915 IntAct P75915 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75915* InterPro IPR020945 http://www.ebi.ac.uk/interpro/entry/IPR020945 InterPro IPR026269 http://www.ebi.ac.uk/interpro/entry/IPR026269 KEGG_Gene ecj:JW1018 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1018 KEGG_Gene eco:b1035 http://www.genome.jp/dbget-bin/www_bget?eco:b1035 OMA EFSIVCR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EFSIVCR PSORT swissprot:YCDY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCDY_ECOLI PSORT-B swissprot:YCDY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCDY_ECOLI PSORT2 swissprot:YCDY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCDY_ECOLI Pfam PF02613 http://pfam.xfam.org/family/PF02613 Phobius swissprot:YCDY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCDY_ECOLI PhylomeDB P75915 http://phylomedb.org/?seqid=P75915 ProteinModelPortal P75915 http://www.proteinmodelportal.org/query/uniprot/P75915 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21965574 http://www.ncbi.nlm.nih.gov/pubmed/21965574 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415553 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415553 RefSeq WP_001001921 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001001921 SMR P75915 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75915 STRING 511145.b1035 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1035&targetmode=cogs SUPFAM SSF89155 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF89155 UniProtKB YCDY_ECOLI http://www.uniprot.org/uniprot/YCDY_ECOLI UniProtKB-AC P75915 http://www.uniprot.org/uniprot/P75915 charge swissprot:YCDY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCDY_ECOLI eggNOG COG3381 http://eggnogapi.embl.de/nog_data/html/tree/COG3381 eggNOG ENOG4107XHZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107XHZ epestfind swissprot:YCDY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCDY_ECOLI garnier swissprot:YCDY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCDY_ECOLI helixturnhelix swissprot:YCDY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCDY_ECOLI hmoment swissprot:YCDY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCDY_ECOLI iep swissprot:YCDY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCDY_ECOLI inforesidue swissprot:YCDY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCDY_ECOLI octanol swissprot:YCDY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCDY_ECOLI pepcoil swissprot:YCDY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCDY_ECOLI pepdigest swissprot:YCDY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCDY_ECOLI pepinfo swissprot:YCDY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCDY_ECOLI pepnet swissprot:YCDY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCDY_ECOLI pepstats swissprot:YCDY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCDY_ECOLI pepwheel swissprot:YCDY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCDY_ECOLI pepwindow swissprot:YCDY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCDY_ECOLI sigcleave swissprot:YCDY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCDY_ECOLI ## Database ID URL or Descriptions # AltName ARNC_ECOLI Polymyxin resistance protein PmrF # AltName ARNC_ECOLI Undecaprenyl-phosphate Ara4FN transferase # BioGrid 4260496 313 # CATALYTIC ACTIVITY UDP-4-deoxy-4-formamido-beta-L-arabinose + ditrans,octacis-undecaprenyl phosphate = UDP + 4-deoxy-4- formamido-alpha-L-arabinose ditrans,octacis-undecaprenyl phosphate. {ECO:0000269|PubMed 15695810}. # CAZy GT2 Glycosyltransferase Family 2 # EcoGene EG14090 arnC # FUNCTION ARNC_ECOLI Catalyzes the transfer of 4-deoxy-4-formamido-L- arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. {ECO 0000269|PubMed 11706007}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0016780 phosphotransferase activity, for other substituted phosphate groups; IDA:EcoCyc. # GO_function GO:0103019 undecaprenyl phosphate-L-Ara4FN transferase activity; IEA:UniProtKB-EC. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0009245 lipid A biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0036108 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.90.550.10 -; 1. # HAMAP MF_01164 ArnC_transfer # INDUCTION Induced by BasR. {ECO 0000250}. # IntAct P77757 3 # InterPro IPR001173 Glyco_trans_2-like # InterPro IPR022857 ArnC_tfrase # InterPro IPR029044 Nucleotide-diphossugar_trans # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # KEGG_Pathway ko00520 Amino sugar and nucleotide sugar metabolism # Organism ARNC_ECOLI Escherichia coli (strain K12) # PATHWAY Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. {ECO:0000269|PubMed 17928292}. # PATHWAY Glycolipid biosynthesis; 4-amino-4-deoxy-alpha-L- arabinose undecaprenyl phosphate biosynthesis; 4-amino-4-deoxy- alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4- formamido-beta-L-arabinose and undecaprenyl phosphate: step 1/2. {ECO 0000269|PubMed:17928292}. # PATRIC 32119873 VBIEscCol129921_2346 # PIR D64996 D64996 # Pfam PF00535 Glycos_transf_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ARNC_ECOLI Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase # RefSeq NP_416757 NC_000913.3 # RefSeq WP_000461657 NZ_LN832404.1 # SIMILARITY Belongs to the glycosyltransferase 2 family. {ECO 0000305}. # SUBCELLULAR LOCATION ARNC_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF53448 SSF53448 # TCDB 4.D.2.1 the glycosyl transferase 2 (gt2) family # UniPathway UPA00036 UER00495 # eggNOG COG0463 LUCA # eggNOG ENOG4105CKK Bacteria BLAST swissprot:ARNC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARNC_ECOLI BioCyc ECOL316407:JW2248-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2248-MONOMER BioCyc EcoCyc:G7167-MONOMER http://biocyc.org/getid?id=EcoCyc:G7167-MONOMER BioCyc MetaCyc:G7167-MONOMER http://biocyc.org/getid?id=MetaCyc:G7167-MONOMER COG COG0463 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0463 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M109377200 http://dx.doi.org/10.1074/jbc.M109377200 DOI 10.1074/jbc.M414265200 http://dx.doi.org/10.1074/jbc.M414265200 DOI 10.1074/jbc.M706172200 http://dx.doi.org/10.1074/jbc.M706172200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.4.2.53 http://www.genome.jp/dbget-bin/www_bget?EC:2.4.2.53 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL DQ011863 http://www.ebi.ac.uk/ena/data/view/DQ011863 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.4.2.53 http://enzyme.expasy.org/EC/2.4.2.53 EchoBASE EB3843 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3843 EcoGene EG14090 http://www.ecogene.org/geneInfo.php?eg_id=EG14090 EnsemblBacteria AAC75314 http://www.ensemblgenomes.org/id/AAC75314 EnsemblBacteria AAC75314 http://www.ensemblgenomes.org/id/AAC75314 EnsemblBacteria BAA16077 http://www.ensemblgenomes.org/id/BAA16077 EnsemblBacteria BAA16077 http://www.ensemblgenomes.org/id/BAA16077 EnsemblBacteria BAA16077 http://www.ensemblgenomes.org/id/BAA16077 EnsemblBacteria b2254 http://www.ensemblgenomes.org/id/b2254 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0016780 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016780 GO_function GO:0103019 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0103019 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GO_process GO:0009245 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009245 GO_process GO:0036108 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036108 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.90.550.10 http://www.cathdb.info/version/latest/superfamily/3.90.550.10 GeneID 945275 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945275 HAMAP MF_01164 http://hamap.expasy.org/unirule/MF_01164 HOGENOM HOG000283251 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000283251&db=HOGENOM6 InParanoid P77757 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77757 IntAct P77757 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77757* IntEnz 2.4.2.53 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.2.53 InterPro IPR001173 http://www.ebi.ac.uk/interpro/entry/IPR001173 InterPro IPR022857 http://www.ebi.ac.uk/interpro/entry/IPR022857 InterPro IPR029044 http://www.ebi.ac.uk/interpro/entry/IPR029044 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Gene ecj:JW2248 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2248 KEGG_Gene eco:b2254 http://www.genome.jp/dbget-bin/www_bget?eco:b2254 KEGG_Orthology KO:K10012 http://www.genome.jp/dbget-bin/www_bget?KO:K10012 KEGG_Pathway ko00520 http://www.genome.jp/kegg-bin/show_pathway?ko00520 KEGG_Reaction rn:R07661 http://www.genome.jp/dbget-bin/www_bget?rn:R07661 OMA YGQTPAM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YGQTPAM PSORT swissprot:ARNC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARNC_ECOLI PSORT-B swissprot:ARNC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARNC_ECOLI PSORT2 swissprot:ARNC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARNC_ECOLI Pfam PF00535 http://pfam.xfam.org/family/PF00535 Phobius swissprot:ARNC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARNC_ECOLI PhylomeDB P77757 http://phylomedb.org/?seqid=P77757 ProteinModelPortal P77757 http://www.proteinmodelportal.org/query/uniprot/P77757 PubMed 11706007 http://www.ncbi.nlm.nih.gov/pubmed/11706007 PubMed 15695810 http://www.ncbi.nlm.nih.gov/pubmed/15695810 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17928292 http://www.ncbi.nlm.nih.gov/pubmed/17928292 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416757 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416757 RefSeq WP_000461657 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000461657 SMR P77757 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77757 STRING 511145.b2254 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2254&targetmode=cogs STRING COG0463 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0463&targetmode=cogs SUPFAM SSF53448 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53448 TCDB 4.D.2.1 http://www.tcdb.org/search/result.php?tc=4.D.2.1 UniProtKB ARNC_ECOLI http://www.uniprot.org/uniprot/ARNC_ECOLI UniProtKB-AC P77757 http://www.uniprot.org/uniprot/P77757 charge swissprot:ARNC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARNC_ECOLI eggNOG COG0463 http://eggnogapi.embl.de/nog_data/html/tree/COG0463 eggNOG ENOG4105CKK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CKK epestfind swissprot:ARNC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARNC_ECOLI garnier swissprot:ARNC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARNC_ECOLI helixturnhelix swissprot:ARNC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARNC_ECOLI hmoment swissprot:ARNC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARNC_ECOLI iep swissprot:ARNC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARNC_ECOLI inforesidue swissprot:ARNC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARNC_ECOLI octanol swissprot:ARNC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARNC_ECOLI pepcoil swissprot:ARNC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARNC_ECOLI pepdigest swissprot:ARNC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARNC_ECOLI pepinfo swissprot:ARNC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARNC_ECOLI pepnet swissprot:ARNC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARNC_ECOLI pepstats swissprot:ARNC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARNC_ECOLI pepwheel swissprot:ARNC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARNC_ECOLI pepwindow swissprot:ARNC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARNC_ECOLI sigcleave swissprot:ARNC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARNC_ECOLI ## Database ID URL or Descriptions # BioGrid 4261828 329 # EcoGene EG11008 tolB # FUNCTION TOLB_ECOLI Involved in the TonB-independent uptake of group A colicins (colicins A, E1, E2, E3 and K). Necessary for the colicins to reach their respective targets after initial binding to the bacteria. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_component GO:0032153 cell division site; IDA:EcoCyc. # GO_component GO:0042597 periplasmic space; IDA:EcoliWiki. # GO_process GO:0015031 protein transport; IMP:EcoliWiki. # GO_process GO:0017038 protein import; IMP:EcoliWiki. # GO_process GO:0043213 bacteriocin transport; IMP:EcoliWiki. # GO_process GO:0071237 cellular response to bacteriocin; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # Gene3D 2.130.10.10 -; 1. # Gene3D 3.40.50.10070 -; 1. # HAMAP MF_00671 TolB # INTERACTION TOLB_ECOLI P09883 col (xeno); NbExp=5; IntAct=EBI-7180728, EBI-1029888; P0A912 pal; NbExp=4; IntAct=EBI-7180728, EBI-1124760; P19934 tolA; NbExp=5; IntAct=EBI-7180728, EBI-1120026; # IntAct P0A855 11 # InterPro IPR007195 TolB_N # InterPro IPR011659 PD40 # InterPro IPR014167 Tol-Pal_propeller_TolB # InterPro IPR015943 WD40/YVTN_repeat-like_dom # KEGG_Brite ko02000 Transporters # Organism TOLB_ECOLI Escherichia coli (strain K12) # PATRIC 32116679 VBIEscCol129921_0772 # PDB 1C5K X-ray; 2.00 A; A=1-430 # PDB 1CRZ X-ray; 1.95 A; A=28-430 # PDB 2HQS X-ray; 1.50 A; A/B/D/F=23-430 # PDB 2IVZ X-ray; 2.00 A; A/B/C/D=1-430 # PDB 2W8B X-ray; 1.86 A; A/B/D/F=22-430 # PDB 3IAX X-ray; 2.60 A; A=1-430 # PIR C64810 C64810 # Pfam PF04052 TolB_N # Pfam PF07676 PD40; 4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TOLB_ECOLI Protein TolB # RefSeq NP_415268 NC_000913.3 # RefSeq WP_001295307 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA24684.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the TolB family. {ECO 0000305}. # SUBCELLULAR LOCATION TOLB_ECOLI Periplasm {ECO 0000269|PubMed 7929011}. # SUPFAM SSF52964 SSF52964 # TCDB 2.C.1.2 the tonb-exbb-exbd/tola-tolq-tolr (tonb) family of auxiliary proteins for energization of outer membrane receptor (omr)-mediated active transport # TIGRFAMs TIGR02800 propeller_TolB # eggNOG COG0823 LUCA # eggNOG ENOG4107R6Y Bacteria BLAST swissprot:TOLB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TOLB_ECOLI BioCyc ECOL316407:JW5100-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5100-MONOMER BioCyc EcoCyc:EG11008-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11008-MONOMER BioCyc MetaCyc:EG11008-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11008-MONOMER COG COG0823 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0823 DIP DIP-48262N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48262N DOI 10.1016/S0969-2126(00)80062-3 http://dx.doi.org/10.1016/S0969-2126(00)80062-3 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1107/S0907444997008020 http://dx.doi.org/10.1107/S0907444997008020 DOI 10.1111/j.1365-2958.1992.tb01523.x http://dx.doi.org/10.1111/j.1365-2958.1992.tb01523.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M28232 http://www.ebi.ac.uk/ena/data/view/M28232 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X65796 http://www.ebi.ac.uk/ena/data/view/X65796 EchoBASE EB1001 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1001 EcoGene EG11008 http://www.ecogene.org/geneInfo.php?eg_id=EG11008 EnsemblBacteria AAC73834 http://www.ensemblgenomes.org/id/AAC73834 EnsemblBacteria AAC73834 http://www.ensemblgenomes.org/id/AAC73834 EnsemblBacteria BAA35406 http://www.ensemblgenomes.org/id/BAA35406 EnsemblBacteria BAA35406 http://www.ensemblgenomes.org/id/BAA35406 EnsemblBacteria BAA35406 http://www.ensemblgenomes.org/id/BAA35406 EnsemblBacteria b0740 http://www.ensemblgenomes.org/id/b0740 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_component GO:0032153 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032153 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_process GO:0015031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031 GO_process GO:0017038 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017038 GO_process GO:0043213 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043213 GO_process GO:0071237 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071237 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 2.130.10.10 http://www.cathdb.info/version/latest/superfamily/2.130.10.10 Gene3D 3.40.50.10070 http://www.cathdb.info/version/latest/superfamily/3.40.50.10070 GeneID 945429 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945429 HAMAP MF_00671 http://hamap.expasy.org/unirule/MF_00671 HOGENOM HOG000004098 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000004098&db=HOGENOM6 InParanoid P0A855 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A855 IntAct P0A855 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A855* InterPro IPR007195 http://www.ebi.ac.uk/interpro/entry/IPR007195 InterPro IPR011659 http://www.ebi.ac.uk/interpro/entry/IPR011659 InterPro IPR014167 http://www.ebi.ac.uk/interpro/entry/IPR014167 InterPro IPR015943 http://www.ebi.ac.uk/interpro/entry/IPR015943 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5100 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5100 KEGG_Gene eco:b0740 http://www.genome.jp/dbget-bin/www_bget?eco:b0740 KEGG_Orthology KO:K03641 http://www.genome.jp/dbget-bin/www_bget?KO:K03641 MINT MINT-7888580 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-7888580 OMA VREPSWG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VREPSWG PDB 1C5K http://www.ebi.ac.uk/pdbe-srv/view/entry/1C5K PDB 1CRZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1CRZ PDB 2HQS http://www.ebi.ac.uk/pdbe-srv/view/entry/2HQS PDB 2IVZ http://www.ebi.ac.uk/pdbe-srv/view/entry/2IVZ PDB 2W8B http://www.ebi.ac.uk/pdbe-srv/view/entry/2W8B PDB 3IAX http://www.ebi.ac.uk/pdbe-srv/view/entry/3IAX PDBsum 1C5K http://www.ebi.ac.uk/pdbsum/1C5K PDBsum 1CRZ http://www.ebi.ac.uk/pdbsum/1CRZ PDBsum 2HQS http://www.ebi.ac.uk/pdbsum/2HQS PDBsum 2IVZ http://www.ebi.ac.uk/pdbsum/2IVZ PDBsum 2W8B http://www.ebi.ac.uk/pdbsum/2W8B PDBsum 3IAX http://www.ebi.ac.uk/pdbsum/3IAX PSORT swissprot:TOLB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TOLB_ECOLI PSORT-B swissprot:TOLB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TOLB_ECOLI PSORT2 swissprot:TOLB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TOLB_ECOLI Pfam PF04052 http://pfam.xfam.org/family/PF04052 Pfam PF07676 http://pfam.xfam.org/family/PF07676 Phobius swissprot:TOLB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TOLB_ECOLI PhylomeDB P0A855 http://phylomedb.org/?seqid=P0A855 ProteinModelPortal P0A855 http://www.proteinmodelportal.org/query/uniprot/P0A855 PubMed 10545334 http://www.ncbi.nlm.nih.gov/pubmed/10545334 PubMed 1574003 http://www.ncbi.nlm.nih.gov/pubmed/1574003 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2687247 http://www.ncbi.nlm.nih.gov/pubmed/2687247 PubMed 7929011 http://www.ncbi.nlm.nih.gov/pubmed/7929011 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9761825 http://www.ncbi.nlm.nih.gov/pubmed/9761825 RefSeq NP_415268 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415268 RefSeq WP_001295307 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295307 SMR P0A855 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A855 STRING 511145.b0740 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0740&targetmode=cogs STRING COG0823 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0823&targetmode=cogs SUPFAM SSF52964 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52964 SWISS-2DPAGE P0A855 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A855 TCDB 2.C.1.2 http://www.tcdb.org/search/result.php?tc=2.C.1.2 TIGRFAMs TIGR02800 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02800 UniProtKB TOLB_ECOLI http://www.uniprot.org/uniprot/TOLB_ECOLI UniProtKB-AC P0A855 http://www.uniprot.org/uniprot/P0A855 charge swissprot:TOLB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TOLB_ECOLI eggNOG COG0823 http://eggnogapi.embl.de/nog_data/html/tree/COG0823 eggNOG ENOG4107R6Y http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107R6Y epestfind swissprot:TOLB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TOLB_ECOLI garnier swissprot:TOLB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TOLB_ECOLI helixturnhelix swissprot:TOLB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TOLB_ECOLI hmoment swissprot:TOLB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TOLB_ECOLI iep swissprot:TOLB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TOLB_ECOLI inforesidue swissprot:TOLB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TOLB_ECOLI octanol swissprot:TOLB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TOLB_ECOLI pepcoil swissprot:TOLB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TOLB_ECOLI pepdigest swissprot:TOLB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TOLB_ECOLI pepinfo swissprot:TOLB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TOLB_ECOLI pepnet swissprot:TOLB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TOLB_ECOLI pepstats swissprot:TOLB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TOLB_ECOLI pepwheel swissprot:TOLB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TOLB_ECOLI pepwindow swissprot:TOLB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TOLB_ECOLI sigcleave swissprot:TOLB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TOLB_ECOLI ## Database ID URL or Descriptions # BioGrid 4259529 13 # EcoGene EG13217 ybaE # GO_component GO:0030288 outer membrane-bounded periplasmic space; IBA:GO_Central. # GO_function GO:0015197 peptide transporter activity; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # IntAct P46890 4 # InterPro IPR000914 SBP_5_dom # InterPro IPR025370 SgrR_HTH_N # Organism YBAE_ECOLI Escherichia coli (strain K12) # PATRIC 32116043 VBIEscCol129921_0463 # PIR E64774 E64774 # Pfam PF00496 SBP_bac_5 # Pfam PF12793 SgrR_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBAE_ECOLI Uncharacterized protein YbaE # RefSeq NP_414979 NC_000913.3 # RefSeq WP_001238234 NZ_LN832404.1 # eggNOG COG4533 LUCA # eggNOG ENOG4108NFA Bacteria BLAST swissprot:YBAE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBAE_ECOLI BioCyc ECOL316407:JW0435-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0435-MONOMER BioCyc EcoCyc:EG13217-MONOMER http://biocyc.org/getid?id=EcoCyc:EG13217-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D82943 http://www.ebi.ac.uk/ena/data/view/D82943 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL Z54355 http://www.ebi.ac.uk/ena/data/view/Z54355 EchoBASE EB3008 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3008 EcoGene EG13217 http://www.ecogene.org/geneInfo.php?eg_id=EG13217 EnsemblBacteria AAC73548 http://www.ensemblgenomes.org/id/AAC73548 EnsemblBacteria AAC73548 http://www.ensemblgenomes.org/id/AAC73548 EnsemblBacteria BAE76225 http://www.ensemblgenomes.org/id/BAE76225 EnsemblBacteria BAE76225 http://www.ensemblgenomes.org/id/BAE76225 EnsemblBacteria BAE76225 http://www.ensemblgenomes.org/id/BAE76225 EnsemblBacteria b0445 http://www.ensemblgenomes.org/id/b0445 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0015197 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015197 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GeneID 949093 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949093 HOGENOM HOG000117588 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117588&db=HOGENOM6 InParanoid P46890 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P46890 IntAct P46890 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P46890* InterPro IPR000914 http://www.ebi.ac.uk/interpro/entry/IPR000914 InterPro IPR025370 http://www.ebi.ac.uk/interpro/entry/IPR025370 KEGG_Gene ecj:JW0435 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0435 KEGG_Gene eco:b0445 http://www.genome.jp/dbget-bin/www_bget?eco:b0445 OMA LFNYQYQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LFNYQYQ PSORT swissprot:YBAE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBAE_ECOLI PSORT-B swissprot:YBAE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBAE_ECOLI PSORT2 swissprot:YBAE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBAE_ECOLI Pfam PF00496 http://pfam.xfam.org/family/PF00496 Pfam PF12793 http://pfam.xfam.org/family/PF12793 Phobius swissprot:YBAE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBAE_ECOLI PhylomeDB P46890 http://phylomedb.org/?seqid=P46890 ProteinModelPortal P46890 http://www.proteinmodelportal.org/query/uniprot/P46890 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414979 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414979 RefSeq WP_001238234 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001238234 STRING 511145.b0445 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0445&targetmode=cogs UniProtKB YBAE_ECOLI http://www.uniprot.org/uniprot/YBAE_ECOLI UniProtKB-AC P46890 http://www.uniprot.org/uniprot/P46890 charge swissprot:YBAE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBAE_ECOLI eggNOG COG4533 http://eggnogapi.embl.de/nog_data/html/tree/COG4533 eggNOG ENOG4108NFA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108NFA epestfind swissprot:YBAE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBAE_ECOLI garnier swissprot:YBAE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBAE_ECOLI helixturnhelix swissprot:YBAE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBAE_ECOLI hmoment swissprot:YBAE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBAE_ECOLI iep swissprot:YBAE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBAE_ECOLI inforesidue swissprot:YBAE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBAE_ECOLI octanol swissprot:YBAE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBAE_ECOLI pepcoil swissprot:YBAE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBAE_ECOLI pepdigest swissprot:YBAE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBAE_ECOLI pepinfo swissprot:YBAE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBAE_ECOLI pepnet swissprot:YBAE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBAE_ECOLI pepstats swissprot:YBAE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBAE_ECOLI pepwheel swissprot:YBAE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBAE_ECOLI pepwindow swissprot:YBAE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBAE_ECOLI sigcleave swissprot:YBAE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBAE_ECOLI ## Database ID URL or Descriptions # DrugBank DB00698 Nitrofurantoin # EcoGene EG10909 rpsJ # FUNCTION RS10_ECOLI Involved in the binding of tRNA to the ribosomes. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0022627 cytosolic small ribosomal subunit; IDA:EcoliWiki. # GO_function GO:0000049 tRNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0001072 transcription antitermination factor activity, RNA binding; IDA:EcoCyc. # GO_function GO:0003735 structural constituent of ribosome; IBA:GO_Central. # GO_process GO:0006412 translation; IEA:UniProtKB-HAMAP. # GO_process GO:0031564 transcription antitermination; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_process GO:0006412 translation # GOslim_process GO:0008150 biological_process # Gene3D 3.30.70.600 -; 1. # HAMAP MF_00508 Ribosomal_S10 # INTERACTION RS10_ECOLI P0A780 nusB; NbExp=5; IntAct=EBI-544602, EBI-555387; P0AA43 rsuA; NbExp=2; IntAct=EBI-544602, EBI-557810; # IntAct P0A7R5 98 # InterPro IPR001848 Ribosomal_S10 # InterPro IPR018268 Ribosomal_S10_CS # InterPro IPR027486 Ribosomal_S10_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 M00179 Ribosome, archaea # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=11734.5; Method=MALDI; Range=1-103; Evidence={ECO:0000269|PubMed 10094780}; # Organism RS10_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11700 PTHR11700 # PATRIC 32122074 VBIEscCol129921_3414 # PDB 1M5G Model; -; J=5-102 # PDB 2KVQ NMR; -; E=1-45, E=68-103 # PDB 2YKR EM; 9.80 A; J=5-102 # PDB 3D3B X-ray; 1.30 A; J=1-45, J=68-103 # PDB 3D3C X-ray; 2.60 A; J/K/L=1-45, J/K/L=68-103 # PDB 3IMQ X-ray; 2.50 A; J/K/L=1-103 # PDB 3J9Y EM; 3.90 A; j=1-103 # PDB 3J9Z EM; 3.60 A; SJ=1-103 # PDB 3JA1 EM; 3.60 A; SJ=1-103 # PDB 3JBU EM; 3.64 A; J=1-103 # PDB 3JBV EM; 3.32 A; J=1-103 # PDB 3JCD EM; 3.70 A; j=1-103 # PDB 3JCE EM; 3.20 A; j=1-103 # PDB 3JCJ EM; 3.70 A; r=1-102 # PDB 3JCN EM; 4.60 A; m=1-102 # PDB 3W1Y X-ray; 2.30 A; C=1-103 # PDB 4A2I EM; 16.50 A; J=5-102 # PDB 4ADV EM; 13.50 A; J=1-103 # PDB 4U1U X-ray; 2.95 A; AJ/CJ=5-102 # PDB 4U1V X-ray; 3.00 A; AJ/CJ=5-102 # PDB 4U20 X-ray; 2.90 A; AJ/CJ=5-102 # PDB 4U24 X-ray; 2.90 A; AJ/CJ=5-102 # PDB 4U25 X-ray; 2.90 A; AJ/CJ=5-102 # PDB 4U26 X-ray; 2.80 A; AJ/CJ=5-102 # PDB 4U27 X-ray; 2.80 A; AJ/CJ=5-102 # PDB 4V47 EM; 12.30 A; BJ=1-103 # PDB 4V48 EM; 11.50 A; BJ=1-103 # PDB 4V4H X-ray; 3.46 A; AJ/CJ=1-103 # PDB 4V4Q X-ray; 3.46 A; AJ/CJ=1-103 # PDB 4V4V EM; 15.00 A; AJ=5-100 # PDB 4V4W EM; 15.00 A; AJ=5-100 # PDB 4V50 X-ray; 3.22 A; AJ/CJ=1-103 # PDB 4V52 X-ray; 3.21 A; AJ/CJ=1-103 # PDB 4V53 X-ray; 3.54 A; AJ/CJ=1-103 # PDB 4V54 X-ray; 3.30 A; AJ/CJ=1-103 # PDB 4V55 X-ray; 4.00 A; AJ/CJ=1-103 # PDB 4V56 X-ray; 3.93 A; AJ/CJ=1-103 # PDB 4V57 X-ray; 3.50 A; AJ/CJ=1-103 # PDB 4V5B X-ray; 3.74 A; BJ/DJ=1-103 # PDB 4V5H EM; 5.80 A; AJ=5-102 # PDB 4V5Y X-ray; 4.45 A; AJ/CJ=1-103 # PDB 4V64 X-ray; 3.50 A; AJ/CJ=1-103 # PDB 4V65 EM; 9.00 A; AX=1-103 # PDB 4V66 EM; 9.00 A; AX=1-103 # PDB 4V69 EM; 6.70 A; AJ=5-102 # PDB 4V6C X-ray; 3.19 A; AJ/CJ=1-103 # PDB 4V6D X-ray; 3.81 A; AJ/CJ=1-103 # PDB 4V6E X-ray; 3.71 A; AJ/CJ=1-103 # PDB 4V6K EM; 8.25 A; BN=1-103 # PDB 4V6L EM; 13.20 A; AN=1-103 # PDB 4V6M EM; 7.10 A; AJ=1-103 # PDB 4V6N EM; 12.10 A; BM=1-103 # PDB 4V6O EM; 14.70 A; AM=1-103 # PDB 4V6P EM; 13.50 A; AM=1-103 # PDB 4V6Q EM; 11.50 A; AM=1-103 # PDB 4V6R EM; 11.50 A; AM=1-103 # PDB 4V6S EM; 13.10 A; BL=1-103 # PDB 4V6T EM; 8.30 A; AJ=5-102 # PDB 4V6V EM; 9.80 A; AJ=1-103 # PDB 4V6Y EM; 12.00 A; AJ=5-102 # PDB 4V6Z EM; 12.00 A; AJ=5-102 # PDB 4V70 EM; 17.00 A; AJ=5-102 # PDB 4V71 EM; 20.00 A; AJ=5-102 # PDB 4V72 EM; 13.00 A; AJ=5-102 # PDB 4V73 EM; 15.00 A; AJ=5-102 # PDB 4V74 EM; 17.00 A; AJ=5-102 # PDB 4V75 EM; 12.00 A; AJ=5-102 # PDB 4V76 EM; 17.00 A; AJ=5-102 # PDB 4V77 EM; 17.00 A; AJ=5-102 # PDB 4V78 EM; 20.00 A; AJ=5-102 # PDB 4V79 EM; 15.00 A; AJ=5-102 # PDB 4V7A EM; 9.00 A; AJ=5-102 # PDB 4V7B EM; 6.80 A; AJ=1-103 # PDB 4V7C EM; 7.60 A; AJ=1-103 # PDB 4V7D EM; 7.60 A; BJ=1-103 # PDB 4V7I EM; 9.60 A; BJ=1-103 # PDB 4V7S X-ray; 3.25 A; AJ/CJ=5-102 # PDB 4V7T X-ray; 3.19 A; AJ/CJ=5-102 # PDB 4V7U X-ray; 3.10 A; AJ/CJ=5-102 # PDB 4V7V X-ray; 3.29 A; AJ/CJ=5-102 # PDB 4V85 X-ray; 3.20 A; J=1-103 # PDB 4V89 X-ray; 3.70 A; AJ=1-103 # PDB 4V9C X-ray; 3.30 A; AJ/CJ=1-103 # PDB 4V9D X-ray; 3.00 A; AJ/BJ=5-102 # PDB 4V9O X-ray; 2.90 A; BJ/DJ/FJ/HJ=1-103 # PDB 4V9P X-ray; 2.90 A; BJ/DJ/FJ/HJ=1-103 # PDB 4WF1 X-ray; 3.09 A; AJ/CJ=5-102 # PDB 4WOI X-ray; 3.00 A; AJ/DJ=1-103 # PDB 4WWW X-ray; 3.10 A; QJ/XJ=5-102 # PDB 4YBB X-ray; 2.10 A; AJ/BJ=4-102 # PDB 5AFI EM; 2.90 A; j=1-103 # PDB 5IQR EM; 3.00 A; o=1-103 # PDB 5IT8 X-ray; 3.12 A; AJ/BJ=4-102 # PDB 5J5B X-ray; 2.80 A; AJ/BJ=4-102 # PDB 5J7L X-ray; 3.00 A; AJ/BJ=4-102 # PDB 5J88 X-ray; 3.32 A; AJ/BJ=4-102 # PDB 5J8A X-ray; 3.10 A; AJ/BJ=4-102 # PDB 5J91 X-ray; 2.96 A; AJ/BJ=4-102 # PDB 5JC9 X-ray; 3.03 A; AJ/BJ=4-102 # PDB 5JTE EM; 3.60 A; AJ=1-103 # PDB 5JU8 EM; 3.60 A; AJ=1-103 # PDB 5KCR EM; 3.60 A; 1j=1-103 # PDB 5KCS EM; 3.90 A; 1j=1-103 # PDB 5KPS EM; 3.90 A; 15=1-103 # PDB 5KPV EM; 4.10 A; 14=1-103 # PDB 5KPW EM; 3.90 A; 14=1-103 # PDB 5KPX EM; 3.90 A; 14=1-103 # PDB 5L3P EM; 3.70 A; j=1-103 # PIR A02720 R3EC10 # PRINTS PR00971 RIBOSOMALS10 # PROSITE PS00361 RIBOSOMAL_S10 # Pfam PF00338 Ribosomal_S10 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RS10_ECOLI 30S ribosomal protein S10 # RefSeq NP_417780 NC_000913.3 # RefSeq WP_001181004 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein S10P family. {ECO 0000305}. # SMART SM01403 Ribosomal_S10 # SUBUNIT Part of the 30S ribosomal subunit. {ECO 0000250}. # SUPFAM SSF54999 SSF54999 # TIGRFAMs TIGR01049 rpsJ_bact # eggNOG COG0051 LUCA # eggNOG ENOG4108Z10 Bacteria BLAST swissprot:RS10_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RS10_ECOLI BioCyc ECOL316407:JW3283-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3283-MONOMER BioCyc EcoCyc:EG10909-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10909-MONOMER BioCyc MetaCyc:EG10909-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10909-MONOMER COG COG0051 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0051 DIP DIP-35797N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35797N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1016/0014-5793(80)81277-4 http://dx.doi.org/10.1016/0014-5793(80)81277-4 DOI 10.1016/0092-8674(81)90303-2 http://dx.doi.org/10.1016/0092-8674(81)90303-2 DOI 10.1016/S0092-8674(03)00427-6 http://dx.doi.org/10.1016/S0092-8674(03)00427-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb841 http://dx.doi.org/10.1038/nsb841 DOI 10.1093/nar/13.12.4521 http://dx.doi.org/10.1093/nar/13.12.4521 DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB00698 http://www.drugbank.ca/drugs/DB00698 EMBL AF058450 http://www.ebi.ac.uk/ena/data/view/AF058450 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL V00344 http://www.ebi.ac.uk/ena/data/view/V00344 EMBL X02613 http://www.ebi.ac.uk/ena/data/view/X02613 EchoBASE EB0902 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0902 EcoGene EG10909 http://www.ecogene.org/geneInfo.php?eg_id=EG10909 EnsemblBacteria AAC76346 http://www.ensemblgenomes.org/id/AAC76346 EnsemblBacteria AAC76346 http://www.ensemblgenomes.org/id/AAC76346 EnsemblBacteria BAE77970 http://www.ensemblgenomes.org/id/BAE77970 EnsemblBacteria BAE77970 http://www.ensemblgenomes.org/id/BAE77970 EnsemblBacteria BAE77970 http://www.ensemblgenomes.org/id/BAE77970 EnsemblBacteria b3321 http://www.ensemblgenomes.org/id/b3321 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0022627 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022627 GO_function GO:0000049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000049 GO_function GO:0001072 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001072 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GO_process GO:0031564 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031564 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.30.70.600 http://www.cathdb.info/version/latest/superfamily/3.30.70.600 GeneID 947816 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947816 HAMAP MF_00508 http://hamap.expasy.org/unirule/MF_00508 HOGENOM HOG000270246 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000270246&db=HOGENOM6 InParanoid P0A7R5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7R5 IntAct P0A7R5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7R5* InterPro IPR001848 http://www.ebi.ac.uk/interpro/entry/IPR001848 InterPro IPR018268 http://www.ebi.ac.uk/interpro/entry/IPR018268 InterPro IPR027486 http://www.ebi.ac.uk/interpro/entry/IPR027486 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW3283 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3283 KEGG_Gene eco:b3321 http://www.genome.jp/dbget-bin/www_bget?eco:b3321 KEGG_Orthology KO:K02946 http://www.genome.jp/dbget-bin/www_bget?KO:K02946 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 MINT MINT-1283940 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1283940 OMA IESLMHI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IESLMHI PANTHER PTHR11700 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11700 PDB 1M5G http://www.ebi.ac.uk/pdbe-srv/view/entry/1M5G PDB 2KVQ http://www.ebi.ac.uk/pdbe-srv/view/entry/2KVQ PDB 2YKR http://www.ebi.ac.uk/pdbe-srv/view/entry/2YKR PDB 3D3B http://www.ebi.ac.uk/pdbe-srv/view/entry/3D3B PDB 3D3C http://www.ebi.ac.uk/pdbe-srv/view/entry/3D3C PDB 3IMQ http://www.ebi.ac.uk/pdbe-srv/view/entry/3IMQ PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 3W1Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3W1Y PDB 4A2I http://www.ebi.ac.uk/pdbe-srv/view/entry/4A2I PDB 4ADV http://www.ebi.ac.uk/pdbe-srv/view/entry/4ADV PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4V47 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V47 PDB 4V48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V48 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 1M5G http://www.ebi.ac.uk/pdbsum/1M5G PDBsum 2KVQ http://www.ebi.ac.uk/pdbsum/2KVQ PDBsum 2YKR http://www.ebi.ac.uk/pdbsum/2YKR PDBsum 3D3B http://www.ebi.ac.uk/pdbsum/3D3B PDBsum 3D3C http://www.ebi.ac.uk/pdbsum/3D3C PDBsum 3IMQ http://www.ebi.ac.uk/pdbsum/3IMQ PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 3W1Y http://www.ebi.ac.uk/pdbsum/3W1Y PDBsum 4A2I http://www.ebi.ac.uk/pdbsum/4A2I PDBsum 4ADV http://www.ebi.ac.uk/pdbsum/4ADV PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4V47 http://www.ebi.ac.uk/pdbsum/4V47 PDBsum 4V48 http://www.ebi.ac.uk/pdbsum/4V48 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PRINTS PR00971 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00971 PROSITE PS00361 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00361 PSORT swissprot:RS10_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RS10_ECOLI PSORT-B swissprot:RS10_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RS10_ECOLI PSORT2 swissprot:RS10_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RS10_ECOLI Pfam PF00338 http://pfam.xfam.org/family/PF00338 Phobius swissprot:RS10_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RS10_ECOLI PhylomeDB P0A7R5 http://phylomedb.org/?seqid=P0A7R5 ProteinModelPortal P0A7R5 http://www.proteinmodelportal.org/query/uniprot/P0A7R5 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 12244297 http://www.ncbi.nlm.nih.gov/pubmed/12244297 PubMed 12809609 http://www.ncbi.nlm.nih.gov/pubmed/12809609 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3892488 http://www.ncbi.nlm.nih.gov/pubmed/3892488 PubMed 7007073 http://www.ncbi.nlm.nih.gov/pubmed/7007073 PubMed 7037196 http://www.ncbi.nlm.nih.gov/pubmed/7037196 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_417780 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417780 RefSeq WP_001181004 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001181004 SMART SM01403 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01403 SMR P0A7R5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7R5 STRING 511145.b3321 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3321&targetmode=cogs STRING COG0051 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0051&targetmode=cogs SUPFAM SSF54999 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54999 TIGRFAMs TIGR01049 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01049 UniProtKB RS10_ECOLI http://www.uniprot.org/uniprot/RS10_ECOLI UniProtKB-AC P0A7R5 http://www.uniprot.org/uniprot/P0A7R5 charge swissprot:RS10_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RS10_ECOLI eggNOG COG0051 http://eggnogapi.embl.de/nog_data/html/tree/COG0051 eggNOG ENOG4108Z10 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Z10 epestfind swissprot:RS10_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RS10_ECOLI garnier swissprot:RS10_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RS10_ECOLI helixturnhelix swissprot:RS10_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RS10_ECOLI hmoment swissprot:RS10_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RS10_ECOLI iep swissprot:RS10_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RS10_ECOLI inforesidue swissprot:RS10_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RS10_ECOLI octanol swissprot:RS10_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RS10_ECOLI pepcoil swissprot:RS10_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RS10_ECOLI pepdigest swissprot:RS10_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RS10_ECOLI pepinfo swissprot:RS10_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RS10_ECOLI pepnet swissprot:RS10_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RS10_ECOLI pepstats swissprot:RS10_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RS10_ECOLI pepwheel swissprot:RS10_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RS10_ECOLI pepwindow swissprot:RS10_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RS10_ECOLI sigcleave swissprot:RS10_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RS10_ECOLI ## Database ID URL or Descriptions # BioGrid 4260385 15 # EcoGene EG11656 fliH # FUNCTION FLIH_ECOLI Needed for flagellar regrowth and assembly. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0009288 bacterial-type flagellum; IEA:InterPro. # GO_function GO:0003774 motor activity; IEA:InterPro. # GO_process GO:0015031 protein transport; IEA:UniProtKB-KW. # GO_process GO:0044781 bacterial-type flagellum organization; IEA:UniProtKB-KW. # GO_process GO:0071973 bacterial-type flagellum-dependent cell motility; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_component GO:0043226 organelle # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # GOslim_process GO:0048870 cell motility # IntAct P31068 12 # InterPro IPR000563 Flag_FliH # InterPro IPR018035 Flagellar_FliH/T3SS_HrpE # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko02040 Flagellar assembly # Organism FLIH_ECOLI Escherichia coli (strain K12) # PATRIC 32119209 VBIEscCol129921_2019 # PIR A64958 A64958 # PRINTS PR01003 FLGFLIH # Pfam PF02108 FliH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FLIH_ECOLI Flagellar assembly protein FliH # RefSeq NP_416450 NC_000913.3 # RefSeq WP_001282683 NZ_LN832404.1 # SIMILARITY Belongs to the FliH family. {ECO 0000305}. # SUBCELLULAR LOCATION FLIH_ECOLI Cytoplasm {ECO 0000305}. # eggNOG COG1317 LUCA # eggNOG ENOG41090PJ Bacteria BLAST swissprot:FLIH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLIH_ECOLI BioCyc ECOL316407:JW1924-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1924-MONOMER BioCyc EcoCyc:EG11656-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11656-MONOMER COG COG1317 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1317 DIP DIP-9654N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9654N DOI 10.1016/0378-1119(93)90232-R http://dx.doi.org/10.1016/0378-1119(93)90232-R DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L13243 http://www.ebi.ac.uk/ena/data/view/L13243 EMBL L49147 http://www.ebi.ac.uk/ena/data/view/L49147 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1608 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1608 EcoGene EG11656 http://www.ecogene.org/geneInfo.php?eg_id=EG11656 EnsemblBacteria AAC75007 http://www.ensemblgenomes.org/id/AAC75007 EnsemblBacteria AAC75007 http://www.ensemblgenomes.org/id/AAC75007 EnsemblBacteria BAA15765 http://www.ensemblgenomes.org/id/BAA15765 EnsemblBacteria BAA15765 http://www.ensemblgenomes.org/id/BAA15765 EnsemblBacteria BAA15765 http://www.ensemblgenomes.org/id/BAA15765 EnsemblBacteria b1940 http://www.ensemblgenomes.org/id/b1940 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0009288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009288 GO_function GO:0003774 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003774 GO_process GO:0015031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031 GO_process GO:0044781 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044781 GO_process GO:0071973 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071973 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0043226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 GeneID 946456 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946456 HOGENOM HOG000265861 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000265861&db=HOGENOM6 InParanoid P31068 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31068 IntAct P31068 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31068* InterPro IPR000563 http://www.ebi.ac.uk/interpro/entry/IPR000563 InterPro IPR018035 http://www.ebi.ac.uk/interpro/entry/IPR018035 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW1924 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1924 KEGG_Gene eco:b1940 http://www.genome.jp/dbget-bin/www_bget?eco:b1940 KEGG_Orthology KO:K02411 http://www.genome.jp/dbget-bin/www_bget?KO:K02411 KEGG_Pathway ko02040 http://www.genome.jp/kegg-bin/show_pathway?ko02040 OMA PGGCKIS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PGGCKIS PRINTS PR01003 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01003 PSORT swissprot:FLIH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLIH_ECOLI PSORT-B swissprot:FLIH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLIH_ECOLI PSORT2 swissprot:FLIH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLIH_ECOLI Pfam PF02108 http://pfam.xfam.org/family/PF02108 Phobius swissprot:FLIH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLIH_ECOLI ProteinModelPortal P31068 http://www.proteinmodelportal.org/query/uniprot/P31068 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8224881 http://www.ncbi.nlm.nih.gov/pubmed/8224881 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416450 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416450 RefSeq WP_001282683 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001282683 SMR P31068 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31068 STRING 511145.b1940 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1940&targetmode=cogs STRING COG1317 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1317&targetmode=cogs UniProtKB FLIH_ECOLI http://www.uniprot.org/uniprot/FLIH_ECOLI UniProtKB-AC P31068 http://www.uniprot.org/uniprot/P31068 charge swissprot:FLIH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLIH_ECOLI eggNOG COG1317 http://eggnogapi.embl.de/nog_data/html/tree/COG1317 eggNOG ENOG41090PJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG41090PJ epestfind swissprot:FLIH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLIH_ECOLI garnier swissprot:FLIH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLIH_ECOLI helixturnhelix swissprot:FLIH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLIH_ECOLI hmoment swissprot:FLIH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLIH_ECOLI iep swissprot:FLIH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLIH_ECOLI inforesidue swissprot:FLIH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLIH_ECOLI octanol swissprot:FLIH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLIH_ECOLI pepcoil swissprot:FLIH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLIH_ECOLI pepdigest swissprot:FLIH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLIH_ECOLI pepinfo swissprot:FLIH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLIH_ECOLI pepnet swissprot:FLIH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLIH_ECOLI pepstats swissprot:FLIH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLIH_ECOLI pepwheel swissprot:FLIH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLIH_ECOLI pepwindow swissprot:FLIH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLIH_ECOLI sigcleave swissprot:FLIH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLIH_ECOLI ## Database ID URL or Descriptions # BioGrid 4260531 13 # DISRUPTION PHENOTYPE Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain. {ECO:0000269|PubMed 20345943}. # EcoGene EG14121 yfcR # FUNCTION YFCR_ECOLI Part of the yfcOPQRSUV fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes. {ECO 0000269|PubMed 20345943}. # GO_component GO:0009289 pilus; IEA:InterPro. # GO_process GO:0007155 cell adhesion; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0007155 cell adhesion # Gene3D 2.60.40.1090 -; 1. # INDUCTION Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression. {ECO:0000269|PubMed 20345943}. # IntAct P76501 4 # InterPro IPR000259 Adhesion_dom_fimbrial # InterPro IPR008966 Adhesion_dom # MISCELLANEOUS The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed. {ECO:0000305|PubMed 20345943}. # Organism YFCR_ECOLI Escherichia coli (strain K12) # PATRIC 32120043 VBIEscCol129921_2431 # PIR E65006 E65006 # Pfam PF00419 Fimbrial # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFCR_ECOLI Uncharacterized fimbrial-like protein YfcR # RefSeq NP_416838 NC_000913.3 # SIMILARITY Belongs to the fimbrial protein family. {ECO 0000305}. # SUPFAM SSF49401 SSF49401 # eggNOG ENOG4105NEV Bacteria # eggNOG ENOG4111X56 LUCA BLAST swissprot:YFCR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFCR_ECOLI BioCyc ECOL316407:JW2332-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2332-MONOMER BioCyc EcoCyc:G7206-MONOMER http://biocyc.org/getid?id=EcoCyc:G7206-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1462-2920.2010.02202.x http://dx.doi.org/10.1111/j.1462-2920.2010.02202.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3874 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3874 EcoGene EG14121 http://www.ecogene.org/geneInfo.php?eg_id=EG14121 EnsemblBacteria AAC75395 http://www.ensemblgenomes.org/id/AAC75395 EnsemblBacteria AAC75395 http://www.ensemblgenomes.org/id/AAC75395 EnsemblBacteria BAE76692 http://www.ensemblgenomes.org/id/BAE76692 EnsemblBacteria BAE76692 http://www.ensemblgenomes.org/id/BAE76692 EnsemblBacteria BAE76692 http://www.ensemblgenomes.org/id/BAE76692 EnsemblBacteria b2335 http://www.ensemblgenomes.org/id/b2335 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009289 GO_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 Gene3D 2.60.40.1090 http://www.cathdb.info/version/latest/superfamily/2.60.40.1090 GeneID 946818 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946818 HOGENOM HOG000122523 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122523&db=HOGENOM6 IntAct P76501 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76501* InterPro IPR000259 http://www.ebi.ac.uk/interpro/entry/IPR000259 InterPro IPR008966 http://www.ebi.ac.uk/interpro/entry/IPR008966 KEGG_Gene ecj:JW2332 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2332 KEGG_Gene eco:b2335 http://www.genome.jp/dbget-bin/www_bget?eco:b2335 OMA NTASNFT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NTASNFT PSORT swissprot:YFCR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFCR_ECOLI PSORT-B swissprot:YFCR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFCR_ECOLI PSORT2 swissprot:YFCR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFCR_ECOLI Pfam PF00419 http://pfam.xfam.org/family/PF00419 Phobius swissprot:YFCR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFCR_ECOLI ProteinModelPortal P76501 http://www.proteinmodelportal.org/query/uniprot/P76501 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20345943 http://www.ncbi.nlm.nih.gov/pubmed/20345943 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416838 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416838 SMR P76501 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76501 STRING 511145.b2335 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2335&targetmode=cogs SUPFAM SSF49401 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49401 UniProtKB YFCR_ECOLI http://www.uniprot.org/uniprot/YFCR_ECOLI UniProtKB-AC P76501 http://www.uniprot.org/uniprot/P76501 charge swissprot:YFCR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFCR_ECOLI eggNOG ENOG4105NEV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105NEV eggNOG ENOG4111X56 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111X56 epestfind swissprot:YFCR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFCR_ECOLI garnier swissprot:YFCR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFCR_ECOLI helixturnhelix swissprot:YFCR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFCR_ECOLI hmoment swissprot:YFCR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFCR_ECOLI iep swissprot:YFCR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFCR_ECOLI inforesidue swissprot:YFCR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFCR_ECOLI octanol swissprot:YFCR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFCR_ECOLI pepcoil swissprot:YFCR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFCR_ECOLI pepdigest swissprot:YFCR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFCR_ECOLI pepinfo swissprot:YFCR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFCR_ECOLI pepnet swissprot:YFCR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFCR_ECOLI pepstats swissprot:YFCR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFCR_ECOLI pepwheel swissprot:YFCR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFCR_ECOLI pepwindow swissprot:YFCR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFCR_ECOLI sigcleave swissprot:YFCR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFCR_ECOLI ## Database ID URL or Descriptions # CAUTION Could be the product of a pseudogene, as in E.coli K12 the nmpC open reading frame is interrupted by an IS5 insertion and generates a hybrid open reading frame that is not expressed. In strains which have undergone selection for suppressors of ompB mutations (for example, mutant strain CS384) nmpC is expressed. {ECO 0000305}. # CDD cd00342 gram_neg_porins # EcoGene EG10659 nmpC # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_component GO:0046930 pore complex; IEA:UniProtKB-KW. # GO_function GO:0015288 porin activity; IDA:EcoCyc. # GO_process GO:0006810 transport; IMP:EcoCyc. # GO_process GO:0006811 ion transport; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043234 protein complex # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # Gene3D 2.40.160.10 -; 1. # InterPro IPR001702 Porin_Gram-ve # InterPro IPR001897 Porin_gammaproteobac # InterPro IPR013793 Porin_Gram-ve_CS # InterPro IPR023614 Porin_dom # InterPro IPR033900 Gram_neg_porin_domain # MISCELLANEOUS NMPC_ECOLI Encoded by the cryptic lambdoid prophage DLP12. # Organism NMPC_ECOLI Escherichia coli (strain K12) # PIR A25647 MMECNC # PRINTS PR00182 ECOLNEIPORIN # PRINTS PR00183 ECOLIPORIN # PROSITE PS00576 GRAM_NEG_PORIN # Pfam PF00267 Porin_1 # Proteomes UP000000625 Chromosome # RecName NMPC_ECOLI Putative outer membrane porin protein NmpC # SIMILARITY Belongs to the Gram-negative porin family. {ECO 0000305}. # SUBCELLULAR LOCATION NMPC_ECOLI Cell outer membrane; Multi-pass membrane protein. Note=When expressed in mutant CS384. # SUBUNIT Homotrimer. {ECO 0000250}. # TCDB 1.B.1.1 the general bacterial porin (gbp) family BLAST swissprot:NMPC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NMPC_ECOLI BioCyc EcoCyc:EG10659-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10659-MONOMER DOI 10.1006/jmbi.1996.0185 http://dx.doi.org/10.1006/jmbi.1996.0185 DOI 10.1111/j.1365-2958.1994.tb00997.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb00997.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL M13457 http://www.ebi.ac.uk/ena/data/view/M13457 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EMBL X92587 http://www.ebi.ac.uk/ena/data/view/X92587 EMBL Z35442 http://www.ebi.ac.uk/ena/data/view/Z35442 EchoBASE EB0653 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0653 EcoGene EG10659 http://www.ecogene.org/geneInfo.php?eg_id=EG10659 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0046930 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046930 GO_function GO:0015288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015288 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GO_process GO:0006811 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 2.40.160.10 http://www.cathdb.info/version/latest/superfamily/2.40.160.10 HOGENOM HOG000272406 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000272406&db=HOGENOM6 InParanoid P21420 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P21420 IntAct P21420 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P21420* InterPro IPR001702 http://www.ebi.ac.uk/interpro/entry/IPR001702 InterPro IPR001897 http://www.ebi.ac.uk/interpro/entry/IPR001897 InterPro IPR013793 http://www.ebi.ac.uk/interpro/entry/IPR013793 InterPro IPR023614 http://www.ebi.ac.uk/interpro/entry/IPR023614 InterPro IPR033900 http://www.ebi.ac.uk/interpro/entry/IPR033900 PRINTS PR00182 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00182 PRINTS PR00183 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00183 PROSITE PS00576 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00576 PSORT swissprot:NMPC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NMPC_ECOLI PSORT-B swissprot:NMPC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NMPC_ECOLI PSORT2 swissprot:NMPC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NMPC_ECOLI Pfam PF00267 http://pfam.xfam.org/family/PF00267 Phobius swissprot:NMPC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NMPC_ECOLI PhylomeDB P21420 http://phylomedb.org/?seqid=P21420 ProteinModelPortal P21420 http://www.proteinmodelportal.org/query/uniprot/P21420 PubMed 3017988 http://www.ncbi.nlm.nih.gov/pubmed/3017988 PubMed 8057841 http://www.ncbi.nlm.nih.gov/pubmed/8057841 PubMed 8648624 http://www.ncbi.nlm.nih.gov/pubmed/8648624 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 TCDB 1.B.1.1 http://www.tcdb.org/search/result.php?tc=1.B.1.1 UniProtKB NMPC_ECOLI http://www.uniprot.org/uniprot/NMPC_ECOLI UniProtKB-AC P21420 http://www.uniprot.org/uniprot/P21420 charge swissprot:NMPC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NMPC_ECOLI epestfind swissprot:NMPC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NMPC_ECOLI garnier swissprot:NMPC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NMPC_ECOLI helixturnhelix swissprot:NMPC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NMPC_ECOLI hmoment swissprot:NMPC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NMPC_ECOLI iep swissprot:NMPC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NMPC_ECOLI inforesidue swissprot:NMPC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NMPC_ECOLI octanol swissprot:NMPC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NMPC_ECOLI pepcoil swissprot:NMPC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NMPC_ECOLI pepdigest swissprot:NMPC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NMPC_ECOLI pepinfo swissprot:NMPC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NMPC_ECOLI pepnet swissprot:NMPC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NMPC_ECOLI pepstats swissprot:NMPC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NMPC_ECOLI pepwheel swissprot:NMPC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NMPC_ECOLI pepwindow swissprot:NMPC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NMPC_ECOLI sigcleave swissprot:NMPC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NMPC_ECOLI ## Database ID URL or Descriptions # BioGrid 4261106 7 # EcoGene EG13257 ybbJ # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR002810 NfeD-like_C # Organism YBBJ_ECOLI Escherichia coli (strain K12) # PATRIC 32116135 VBIEscCol129921_0509 # PIR G64779 G64779 # Pfam PF01957 NfeD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBBJ_ECOLI Inner membrane protein YbbJ # RefSeq NP_415021 NC_000913.3 # RefSeq WP_000970323 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAE76267.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY To M.jannaschii MJ0826. {ECO 0000305}. # SUBCELLULAR LOCATION YBBJ_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG COG1585 LUCA # eggNOG ENOG4105G5H Bacteria BLAST swissprot:YBBJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBBJ_ECOLI BioCyc ECOL316407:JW5065-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5065-MONOMER BioCyc EcoCyc:G6264-MONOMER http://biocyc.org/getid?id=EcoCyc:G6264-MONOMER COG COG1585 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1585 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EchoBASE EB3045 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3045 EcoGene EG13257 http://www.ecogene.org/geneInfo.php?eg_id=EG13257 EnsemblBacteria AAC73590 http://www.ensemblgenomes.org/id/AAC73590 EnsemblBacteria AAC73590 http://www.ensemblgenomes.org/id/AAC73590 EnsemblBacteria BAE76267 http://www.ensemblgenomes.org/id/BAE76267 EnsemblBacteria BAE76267 http://www.ensemblgenomes.org/id/BAE76267 EnsemblBacteria BAE76267 http://www.ensemblgenomes.org/id/BAE76267 EnsemblBacteria b0488 http://www.ensemblgenomes.org/id/b0488 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 945126 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945126 HOGENOM HOG000245405 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000245405&db=HOGENOM6 InParanoid P0AAS3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAS3 InterPro IPR002810 http://www.ebi.ac.uk/interpro/entry/IPR002810 KEGG_Gene ecj:JW5065 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5065 KEGG_Gene eco:b0488 http://www.genome.jp/dbget-bin/www_bget?eco:b0488 KEGG_Orthology KO:K07340 http://www.genome.jp/dbget-bin/www_bget?KO:K07340 OMA PGVFLFW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PGVFLFW PSORT swissprot:YBBJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBBJ_ECOLI PSORT-B swissprot:YBBJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBBJ_ECOLI PSORT2 swissprot:YBBJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBBJ_ECOLI Pfam PF01957 http://pfam.xfam.org/family/PF01957 Phobius swissprot:YBBJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBBJ_ECOLI PhylomeDB P0AAS3 http://phylomedb.org/?seqid=P0AAS3 ProteinModelPortal P0AAS3 http://www.proteinmodelportal.org/query/uniprot/P0AAS3 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415021 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415021 RefSeq WP_000970323 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000970323 STRING 511145.b0488 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0488&targetmode=cogs STRING COG1585 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1585&targetmode=cogs UniProtKB YBBJ_ECOLI http://www.uniprot.org/uniprot/YBBJ_ECOLI UniProtKB-AC P0AAS3 http://www.uniprot.org/uniprot/P0AAS3 charge swissprot:YBBJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBBJ_ECOLI eggNOG COG1585 http://eggnogapi.embl.de/nog_data/html/tree/COG1585 eggNOG ENOG4105G5H http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105G5H epestfind swissprot:YBBJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBBJ_ECOLI garnier swissprot:YBBJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBBJ_ECOLI helixturnhelix swissprot:YBBJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBBJ_ECOLI hmoment swissprot:YBBJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBBJ_ECOLI iep swissprot:YBBJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBBJ_ECOLI inforesidue swissprot:YBBJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBBJ_ECOLI octanol swissprot:YBBJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBBJ_ECOLI pepcoil swissprot:YBBJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBBJ_ECOLI pepdigest swissprot:YBBJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBBJ_ECOLI pepinfo swissprot:YBBJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBBJ_ECOLI pepnet swissprot:YBBJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBBJ_ECOLI pepstats swissprot:YBBJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBBJ_ECOLI pepwheel swissprot:YBBJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBBJ_ECOLI pepwindow swissprot:YBBJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBBJ_ECOLI sigcleave swissprot:YBBJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBBJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4263482 633 # EcoGene EG10674 oppA # FUNCTION OPPA_ECOLI This protein is a component of the oligopeptide permease, a binding protein-dependent transport system, it binds peptides up to five amino acids long with high affinity. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IEA:InterPro. # GO_function GO:0015197 peptide transporter activity; IBA:GO_Central. # GO_process GO:0006857 oligopeptide transport; IDA:EcoliWiki. # GO_process GO:0009408 response to heat; IMP:EcoCyc. # GO_process GO:0015031 protein transport; IEA:UniProtKB-KW. # GO_process GO:0055085 transmembrane transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006810 transport # GOslim_process GO:0006950 response to stress # GOslim_process GO:0055085 transmembrane transport # IntAct P23843 2 # InterPro IPR000914 SBP_5_dom # InterPro IPR023765 SBP_5_CS # InterPro IPR030678 Peptide/Ni-bd # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00439 Oligopeptide transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism OPPA_ECOLI Escherichia coli (strain K12) # PATRIC 32117746 VBIEscCol129921_1293 # PDB 3TCF X-ray; 2.00 A; A/B/C/D/E/F/G/H=27-543 # PDB 3TCG X-ray; 2.00 A; A/B/C/D/E/F/G/H=27-543 # PDB 3TCH X-ray; 1.98 A; A=27-543 # PIR F64871 F64871 # PIRSF PIRSF002741 MppA # PROSITE PS01040 SBP_BACTERIAL_5 # Pfam PF00496 SBP_bac_5 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName OPPA_ECOLI Periplasmic oligopeptide-binding protein # RefSeq NP_415759 NC_000913.3 # SIMILARITY Belongs to the bacterial solute-binding protein 5 family. {ECO 0000305}. # SUBCELLULAR LOCATION OPPA_ECOLI Periplasm. # TCDB 3.A.1.5.41 the atp-binding cassette (abc) superfamily # eggNOG COG4166 LUCA # eggNOG ENOG4108J59 Bacteria BLAST swissprot:OPPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:OPPA_ECOLI BioCyc ECOL316407:JW1235-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1235-MONOMER BioCyc EcoCyc:OPPA-MONOMER http://biocyc.org/getid?id=EcoCyc:OPPA-MONOMER COG COG4166 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4166 DIP DIP-10405N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10405N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1998.1726 http://dx.doi.org/10.1006/jmbi.1998.1726 DOI 10.1016/0014-5793(91)80358-A http://dx.doi.org/10.1016/0014-5793(91)80358-A DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D83137 http://www.ebi.ac.uk/ena/data/view/D83137 EMBL J05433 http://www.ebi.ac.uk/ena/data/view/J05433 EMBL M60918 http://www.ebi.ac.uk/ena/data/view/M60918 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X59501 http://www.ebi.ac.uk/ena/data/view/X59501 EchoBASE EB0668 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0668 EcoGene EG10674 http://www.ecogene.org/geneInfo.php?eg_id=EG10674 EnsemblBacteria AAC74325 http://www.ensemblgenomes.org/id/AAC74325 EnsemblBacteria AAC74325 http://www.ensemblgenomes.org/id/AAC74325 EnsemblBacteria BAA14775 http://www.ensemblgenomes.org/id/BAA14775 EnsemblBacteria BAA14775 http://www.ensemblgenomes.org/id/BAA14775 EnsemblBacteria BAA14775 http://www.ensemblgenomes.org/id/BAA14775 EnsemblBacteria b1243 http://www.ensemblgenomes.org/id/b1243 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0015197 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015197 GO_process GO:0006857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006857 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GO_process GO:0015031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 945830 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945830 HOGENOM HOG000179191 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000179191&db=HOGENOM6 InParanoid P23843 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23843 IntAct P23843 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P23843* InterPro IPR000914 http://www.ebi.ac.uk/interpro/entry/IPR000914 InterPro IPR023765 http://www.ebi.ac.uk/interpro/entry/IPR023765 InterPro IPR030678 http://www.ebi.ac.uk/interpro/entry/IPR030678 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1235 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1235 KEGG_Gene eco:b1243 http://www.genome.jp/dbget-bin/www_bget?eco:b1243 KEGG_Orthology KO:K15580 http://www.genome.jp/dbget-bin/www_bget?KO:K15580 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA MSIITKK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MSIITKK PDB 3TCF http://www.ebi.ac.uk/pdbe-srv/view/entry/3TCF PDB 3TCG http://www.ebi.ac.uk/pdbe-srv/view/entry/3TCG PDB 3TCH http://www.ebi.ac.uk/pdbe-srv/view/entry/3TCH PDBsum 3TCF http://www.ebi.ac.uk/pdbsum/3TCF PDBsum 3TCG http://www.ebi.ac.uk/pdbsum/3TCG PDBsum 3TCH http://www.ebi.ac.uk/pdbsum/3TCH PROSITE PS01040 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01040 PSORT swissprot:OPPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:OPPA_ECOLI PSORT-B swissprot:OPPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:OPPA_ECOLI PSORT2 swissprot:OPPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:OPPA_ECOLI Pfam PF00496 http://pfam.xfam.org/family/PF00496 Phobius swissprot:OPPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:OPPA_ECOLI PhylomeDB P23843 http://phylomedb.org/?seqid=P23843 ProteinModelPortal P23843 http://www.proteinmodelportal.org/query/uniprot/P23843 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2015910 http://www.ncbi.nlm.nih.gov/pubmed/2015910 PubMed 2187863 http://www.ncbi.nlm.nih.gov/pubmed/2187863 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 RefSeq NP_415759 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415759 SMR P23843 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P23843 STRING 511145.b1243 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1243&targetmode=cogs STRING COG4166 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4166&targetmode=cogs SWISS-2DPAGE P23843 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P23843 TCDB 3.A.1.5.41 http://www.tcdb.org/search/result.php?tc=3.A.1.5.41 UniProtKB OPPA_ECOLI http://www.uniprot.org/uniprot/OPPA_ECOLI UniProtKB-AC P23843 http://www.uniprot.org/uniprot/P23843 charge swissprot:OPPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:OPPA_ECOLI eggNOG COG4166 http://eggnogapi.embl.de/nog_data/html/tree/COG4166 eggNOG ENOG4108J59 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108J59 epestfind swissprot:OPPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:OPPA_ECOLI garnier swissprot:OPPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:OPPA_ECOLI helixturnhelix swissprot:OPPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:OPPA_ECOLI hmoment swissprot:OPPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:OPPA_ECOLI iep swissprot:OPPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:OPPA_ECOLI inforesidue swissprot:OPPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:OPPA_ECOLI octanol swissprot:OPPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:OPPA_ECOLI pepcoil swissprot:OPPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:OPPA_ECOLI pepdigest swissprot:OPPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:OPPA_ECOLI pepinfo swissprot:OPPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:OPPA_ECOLI pepnet swissprot:OPPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:OPPA_ECOLI pepstats swissprot:OPPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:OPPA_ECOLI pepwheel swissprot:OPPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:OPPA_ECOLI pepwindow swissprot:OPPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:OPPA_ECOLI sigcleave swissprot:OPPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:OPPA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259162 13 # EcoGene EG12710 yedJ # Gene3D 1.10.3210.10 -; 2. # IntAct P46144 13 # InterPro IPR003607 HD/PDEase_dom # InterPro IPR006674 HD_domain # Organism YEDJ_ECOLI Escherichia coli (strain K12) # PATRIC 32119253 VBIEscCol129921_2041 # PDB 3GW7 X-ray; 3.30 A; A/B=1-231 # PIR F64960 F64960 # Pfam PF01966 HD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEDJ_ECOLI Uncharacterized protein YedJ # RefSeq NP_416471 NC_000913.3 # RefSeq WP_000365562 NZ_LN832404.1 # SIMILARITY Contains 1 HD domain. {ECO 0000305}. # SMART SM00471 HDc # eggNOG COG1418 LUCA # eggNOG ENOG4105EST Bacteria BLAST swissprot:YEDJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEDJ_ECOLI BioCyc ECOL316407:JW1945-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1945-MONOMER BioCyc EcoCyc:EG12710-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12710-MONOMER COG COG1418 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1418 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/nar/17.14.5844 http://dx.doi.org/10.1093/nar/17.14.5844 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X13330 http://www.ebi.ac.uk/ena/data/view/X13330 EchoBASE EB2572 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2572 EcoGene EG12710 http://www.ecogene.org/geneInfo.php?eg_id=EG12710 EnsemblBacteria AAC75028 http://www.ensemblgenomes.org/id/AAC75028 EnsemblBacteria AAC75028 http://www.ensemblgenomes.org/id/AAC75028 EnsemblBacteria BAA15790 http://www.ensemblgenomes.org/id/BAA15790 EnsemblBacteria BAA15790 http://www.ensemblgenomes.org/id/BAA15790 EnsemblBacteria BAA15790 http://www.ensemblgenomes.org/id/BAA15790 EnsemblBacteria b1962 http://www.ensemblgenomes.org/id/b1962 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 1.10.3210.10 http://www.cathdb.info/version/latest/superfamily/1.10.3210.10 GeneID 946478 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946478 HOGENOM HOG000034253 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000034253&db=HOGENOM6 InParanoid P46144 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P46144 IntAct P46144 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P46144* InterPro IPR003607 http://www.ebi.ac.uk/interpro/entry/IPR003607 InterPro IPR006674 http://www.ebi.ac.uk/interpro/entry/IPR006674 KEGG_Gene ecj:JW1945 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1945 KEGG_Gene eco:b1962 http://www.genome.jp/dbget-bin/www_bget?eco:b1962 KEGG_Orthology KO:K06950 http://www.genome.jp/dbget-bin/www_bget?KO:K06950 OMA CVAVEKN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CVAVEKN PDB 3GW7 http://www.ebi.ac.uk/pdbe-srv/view/entry/3GW7 PDBsum 3GW7 http://www.ebi.ac.uk/pdbsum/3GW7 PSORT swissprot:YEDJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEDJ_ECOLI PSORT-B swissprot:YEDJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEDJ_ECOLI PSORT2 swissprot:YEDJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEDJ_ECOLI Pfam PF01966 http://pfam.xfam.org/family/PF01966 Phobius swissprot:YEDJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEDJ_ECOLI PhylomeDB P46144 http://phylomedb.org/?seqid=P46144 ProteinModelPortal P46144 http://www.proteinmodelportal.org/query/uniprot/P46144 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2527357 http://www.ncbi.nlm.nih.gov/pubmed/2527357 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416471 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416471 RefSeq WP_000365562 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000365562 SMART SM00471 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00471 SMR P46144 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P46144 STRING 511145.b1962 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1962&targetmode=cogs STRING COG1418 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1418&targetmode=cogs UniProtKB YEDJ_ECOLI http://www.uniprot.org/uniprot/YEDJ_ECOLI UniProtKB-AC P46144 http://www.uniprot.org/uniprot/P46144 charge swissprot:YEDJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEDJ_ECOLI eggNOG COG1418 http://eggnogapi.embl.de/nog_data/html/tree/COG1418 eggNOG ENOG4105EST http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EST epestfind swissprot:YEDJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEDJ_ECOLI garnier swissprot:YEDJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEDJ_ECOLI helixturnhelix swissprot:YEDJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEDJ_ECOLI hmoment swissprot:YEDJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEDJ_ECOLI iep swissprot:YEDJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEDJ_ECOLI inforesidue swissprot:YEDJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEDJ_ECOLI octanol swissprot:YEDJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEDJ_ECOLI pepcoil swissprot:YEDJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEDJ_ECOLI pepdigest swissprot:YEDJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEDJ_ECOLI pepinfo swissprot:YEDJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEDJ_ECOLI pepnet swissprot:YEDJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEDJ_ECOLI pepstats swissprot:YEDJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEDJ_ECOLI pepwheel swissprot:YEDJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEDJ_ECOLI pepwindow swissprot:YEDJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEDJ_ECOLI sigcleave swissprot:YEDJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEDJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4261377 419 # EcoGene EG10298 fepG # FUNCTION FEPG_ECOLI Part of the binding-protein-dependent transport system for ferric enterobactin. Probably responsible for the translocation of the substrate across the membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015620 ferric-enterobactin transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0015685 ferric-enterobactin transport; IMP:EcoCyc. # GO_process GO:0055072 iron ion homeostasis; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0042592 homeostatic process # Gene3D 1.10.3470.10 -; 1. # INDUCTION Controlled in part by the amount of available iron. Induced 1.4-fold by hydroxyurea (PubMed:20005847). {ECO 0000269|PubMed:20005847}. # InterPro IPR000522 ABC_transptr_FecCD # InterPro IPR029022 ABC_BtuC-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00240 Iron complex transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism FEPG_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30472 PTHR30472 # PATRIC 32116354 VBIEscCol129921_0617 # PIR C64792 C64792 # Pfam PF01032 FecCD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FEPG_ECOLI Ferric enterobactin transport system permease protein FepG # RefSeq NP_415121 NC_000913.3 # RefSeq WP_000640988 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION FEPG_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF81345 SSF81345 # TCDB 3.A.1.14 the atp-binding cassette (abc) superfamily # eggNOG COG4779 LUCA # eggNOG ENOG4105TVJ Bacteria BLAST swissprot:FEPG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FEPG_ECOLI BioCyc ECOL316407:JW0581-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0581-MONOMER BioCyc EcoCyc:FEPG-MONOMER http://biocyc.org/getid?id=EcoCyc:FEPG-MONOMER BioCyc MetaCyc:FEPG-MONOMER http://biocyc.org/getid?id=MetaCyc:FEPG-MONOMER COG COG0609 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0609 DIP DIP-9597N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9597N DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1991.tb00788.x http://dx.doi.org/10.1111/j.1365-2958.1991.tb00788.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EMBL X57471 http://www.ebi.ac.uk/ena/data/view/X57471 EchoBASE EB0294 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0294 EcoGene EG10298 http://www.ecogene.org/geneInfo.php?eg_id=EG10298 EnsemblBacteria AAC73690 http://www.ensemblgenomes.org/id/AAC73690 EnsemblBacteria AAC73690 http://www.ensemblgenomes.org/id/AAC73690 EnsemblBacteria BAE76344 http://www.ensemblgenomes.org/id/BAE76344 EnsemblBacteria BAE76344 http://www.ensemblgenomes.org/id/BAE76344 EnsemblBacteria BAE76344 http://www.ensemblgenomes.org/id/BAE76344 EnsemblBacteria b0589 http://www.ensemblgenomes.org/id/b0589 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015620 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015620 GO_process GO:0015685 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015685 GO_process GO:0055072 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055072 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 Gene3D 1.10.3470.10 http://www.cathdb.info/version/latest/superfamily/1.10.3470.10 GeneID 945209 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945209 HOGENOM HOG000045409 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000045409&db=HOGENOM6 InParanoid P23877 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23877 InterPro IPR000522 http://www.ebi.ac.uk/interpro/entry/IPR000522 InterPro IPR029022 http://www.ebi.ac.uk/interpro/entry/IPR029022 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0581 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0581 KEGG_Gene eco:b0589 http://www.genome.jp/dbget-bin/www_bget?eco:b0589 KEGG_Orthology KO:K02015 http://www.genome.jp/dbget-bin/www_bget?KO:K02015 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA MVISSIC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MVISSIC PANTHER PTHR30472 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30472 PSORT swissprot:FEPG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FEPG_ECOLI PSORT-B swissprot:FEPG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FEPG_ECOLI PSORT2 swissprot:FEPG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FEPG_ECOLI Pfam PF01032 http://pfam.xfam.org/family/PF01032 Phobius swissprot:FEPG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FEPG_ECOLI PhylomeDB P23877 http://phylomedb.org/?seqid=P23877 ProteinModelPortal P23877 http://www.proteinmodelportal.org/query/uniprot/P23877 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1838574 http://www.ncbi.nlm.nih.gov/pubmed/1838574 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415121 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415121 RefSeq WP_000640988 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000640988 SMR P23877 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P23877 STRING 511145.b0589 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0589&targetmode=cogs STRING COG0609 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0609&targetmode=cogs SUPFAM SSF81345 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81345 TCDB 3.A.1.14 http://www.tcdb.org/search/result.php?tc=3.A.1.14 UniProtKB FEPG_ECOLI http://www.uniprot.org/uniprot/FEPG_ECOLI UniProtKB-AC P23877 http://www.uniprot.org/uniprot/P23877 charge swissprot:FEPG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FEPG_ECOLI eggNOG COG4779 http://eggnogapi.embl.de/nog_data/html/tree/COG4779 eggNOG ENOG4105TVJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105TVJ epestfind swissprot:FEPG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FEPG_ECOLI garnier swissprot:FEPG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FEPG_ECOLI helixturnhelix swissprot:FEPG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FEPG_ECOLI hmoment swissprot:FEPG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FEPG_ECOLI iep swissprot:FEPG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FEPG_ECOLI inforesidue swissprot:FEPG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FEPG_ECOLI octanol swissprot:FEPG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FEPG_ECOLI pepcoil swissprot:FEPG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FEPG_ECOLI pepdigest swissprot:FEPG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FEPG_ECOLI pepinfo swissprot:FEPG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FEPG_ECOLI pepnet swissprot:FEPG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FEPG_ECOLI pepstats swissprot:FEPG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FEPG_ECOLI pepwheel swissprot:FEPG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FEPG_ECOLI pepwindow swissprot:FEPG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FEPG_ECOLI sigcleave swissprot:FEPG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FEPG_ECOLI ## Database ID URL or Descriptions # DrugBank DB00759 Tetracycline # EcoGene EG10907 rpsH # FUNCTION RS8_ECOLI One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit. {ECO 0000250}. # FUNCTION RS8_ECOLI Protein S8 is a translational repressor protein, it controls the translation of the spc operon by binding to its mRNA. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0022627 cytosolic small ribosomal subunit; IDA:EcoliWiki. # GO_function GO:0003735 structural constituent of ribosome; IBA:GO_Central. # GO_function GO:0019843 rRNA binding; IDA:EcoliWiki. # GO_process GO:0006412 translation; IEA:UniProtKB-HAMAP. # GO_process GO:0006417 regulation of translation; IEA:UniProtKB-KW. # GO_process GO:0043488 regulation of mRNA stability; IMP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_function GO:0019843 rRNA binding # GOslim_process GO:0006412 translation # GOslim_process GO:0008150 biological_process # HAMAP MF_01302_B Ribosomal_S8_B # IntAct P0A7W7 38 # InterPro IPR000630 Ribosomal_S8 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 M00179 Ribosome, archaea # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=13993.2; Method=MALDI; Range=2-130; Evidence={ECO:0000269|PubMed 10094780}; # Organism RS8_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11758 PTHR11758 # PATRIC 32122044 VBIEscCol129921_3399 # PDB 1EG0 EM; 11.50 A; E=1-130 # PDB 1M5G Model; -; H=2-130 # PDB 1S03 X-ray; 2.70 A; G/H=2-130 # PDB 2YKR EM; 9.80 A; H=2-130 # PDB 3J9Y EM; 3.90 A; h=1-130 # PDB 3J9Z EM; 3.60 A; SH=2-130 # PDB 3JA1 EM; 3.60 A; SH=2-130 # PDB 3JBU EM; 3.64 A; H=1-130 # PDB 3JBV EM; 3.32 A; H=1-130 # PDB 3JCD EM; 3.70 A; h=1-130 # PDB 3JCE EM; 3.20 A; h=1-130 # PDB 3JCJ EM; 3.70 A; p=1-130 # PDB 3JCN EM; 4.60 A; k=1-130 # PDB 4A2I EM; 16.50 A; H=2-130 # PDB 4ADV EM; 13.50 A; H=2-130 # PDB 4U1U X-ray; 2.95 A; AH/CH=2-130 # PDB 4U1V X-ray; 3.00 A; AH/CH=2-130 # PDB 4U20 X-ray; 2.90 A; AH/CH=2-130 # PDB 4U24 X-ray; 2.90 A; AH/CH=2-130 # PDB 4U25 X-ray; 2.90 A; AH/CH=2-130 # PDB 4U26 X-ray; 2.80 A; AH/CH=2-130 # PDB 4U27 X-ray; 2.80 A; AH/CH=2-130 # PDB 4V47 EM; 12.30 A; BH=2-130 # PDB 4V48 EM; 11.50 A; BH=2-130 # PDB 4V4H X-ray; 3.46 A; AH/CH=1-130 # PDB 4V4Q X-ray; 3.46 A; AH/CH=2-130 # PDB 4V4V EM; 15.00 A; AH=3-129 # PDB 4V4W EM; 15.00 A; AH=3-129 # PDB 4V50 X-ray; 3.22 A; AH/CH=2-130 # PDB 4V52 X-ray; 3.21 A; AH/CH=2-130 # PDB 4V53 X-ray; 3.54 A; AH/CH=2-130 # PDB 4V54 X-ray; 3.30 A; AH/CH=2-130 # PDB 4V55 X-ray; 4.00 A; AH/CH=2-130 # PDB 4V56 X-ray; 3.93 A; AH/CH=2-130 # PDB 4V57 X-ray; 3.50 A; AH/CH=2-130 # PDB 4V5B X-ray; 3.74 A; BH/DH=2-130 # PDB 4V5H EM; 5.80 A; AH=2-130 # PDB 4V5Y X-ray; 4.45 A; AH/CH=2-130 # PDB 4V64 X-ray; 3.50 A; AH/CH=2-130 # PDB 4V65 EM; 9.00 A; AV=1-130 # PDB 4V66 EM; 9.00 A; AV=1-130 # PDB 4V69 EM; 6.70 A; AH=2-130 # PDB 4V6C X-ray; 3.19 A; AH/CH=1-130 # PDB 4V6D X-ray; 3.81 A; AH/CH=1-130 # PDB 4V6E X-ray; 3.71 A; AH/CH=1-130 # PDB 4V6K EM; 8.25 A; BL=1-130 # PDB 4V6L EM; 13.20 A; AL=1-130 # PDB 4V6M EM; 7.10 A; AH=2-130 # PDB 4V6N EM; 12.10 A; BK=2-130 # PDB 4V6O EM; 14.70 A; AK=2-130 # PDB 4V6P EM; 13.50 A; AK=2-130 # PDB 4V6Q EM; 11.50 A; AK=2-130 # PDB 4V6R EM; 11.50 A; AK=2-130 # PDB 4V6S EM; 13.10 A; BJ=2-130 # PDB 4V6T EM; 8.30 A; AH=2-130 # PDB 4V6V EM; 9.80 A; AH=2-130 # PDB 4V6Y EM; 12.00 A; AH=1-130 # PDB 4V6Z EM; 12.00 A; AH=1-130 # PDB 4V70 EM; 17.00 A; AH=1-130 # PDB 4V71 EM; 20.00 A; AH=1-130 # PDB 4V72 EM; 13.00 A; AH=1-130 # PDB 4V73 EM; 15.00 A; AH=1-130 # PDB 4V74 EM; 17.00 A; AH=1-130 # PDB 4V75 EM; 12.00 A; AH=1-130 # PDB 4V76 EM; 17.00 A; AH=1-130 # PDB 4V77 EM; 17.00 A; AH=1-130 # PDB 4V78 EM; 20.00 A; AH=1-130 # PDB 4V79 EM; 15.00 A; AH=1-130 # PDB 4V7A EM; 9.00 A; AH=1-130 # PDB 4V7B EM; 6.80 A; AH=1-130 # PDB 4V7C EM; 7.60 A; AH=2-130 # PDB 4V7D EM; 7.60 A; BH=2-130 # PDB 4V7I EM; 9.60 A; BH=1-130 # PDB 4V7S X-ray; 3.25 A; AH/CH=2-130 # PDB 4V7T X-ray; 3.19 A; AH/CH=2-130 # PDB 4V7U X-ray; 3.10 A; AH/CH=2-130 # PDB 4V7V X-ray; 3.29 A; AH/CH=2-130 # PDB 4V85 X-ray; 3.20 A; H=1-130 # PDB 4V89 X-ray; 3.70 A; AH=1-130 # PDB 4V9C X-ray; 3.30 A; AH/CH=1-130 # PDB 4V9D X-ray; 3.00 A; AH/BH=2-130 # PDB 4V9O X-ray; 2.90 A; BH/DH/FH/HH=1-130 # PDB 4V9P X-ray; 2.90 A; BH/DH/FH/HH=1-130 # PDB 4WF1 X-ray; 3.09 A; AH/CH=2-130 # PDB 4WOI X-ray; 3.00 A; AH/DH=1-130 # PDB 4WWW X-ray; 3.10 A; QH/XH=2-130 # PDB 4YBB X-ray; 2.10 A; AH/BH=2-130 # PDB 5AFI EM; 2.90 A; h=1-130 # PDB 5IQR EM; 3.00 A; m=1-130 # PDB 5IT8 X-ray; 3.12 A; AH/BH=2-130 # PDB 5J5B X-ray; 2.80 A; AH/BH=2-130 # PDB 5J7L X-ray; 3.00 A; AH/BH=2-130 # PDB 5J88 X-ray; 3.32 A; AH/BH=2-130 # PDB 5J8A X-ray; 3.10 A; AH/BH=2-130 # PDB 5J91 X-ray; 2.96 A; AH/BH=2-130 # PDB 5JC9 X-ray; 3.03 A; AH/BH=2-130 # PDB 5JTE EM; 3.60 A; AH=1-130 # PDB 5JU8 EM; 3.60 A; AH=1-130 # PDB 5KCR EM; 3.60 A; 1h=1-130 # PDB 5KCS EM; 3.90 A; 1h=1-130 # PDB 5KPS EM; 3.90 A; 13=1-130 # PDB 5KPV EM; 4.10 A; 12=1-130 # PDB 5KPW EM; 3.90 A; 12=1-130 # PDB 5KPX EM; 3.90 A; 12=1-130 # PDB 5L3P EM; 3.70 A; h=1-130 # PIR E65123 R3EC8 # PROSITE PS00053 RIBOSOMAL_S8 # Pfam PF00410 Ribosomal_S8 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RS8_ECOLI 30S ribosomal protein S8 # RefSeq NP_417765 NC_000913.3 # RefSeq WP_000062611 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein S8P family. {ECO 0000305}. # SUBUNIT Part of the 30S ribosomal subunit. Contacts proteins S5 and S12 (By similarity). {ECO 0000250}. # SUPFAM SSF56047 SSF56047 # eggNOG COG0096 LUCA BLAST swissprot:RS8_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RS8_ECOLI BioCyc ECOL316407:JW3268-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3268-MONOMER BioCyc EcoCyc:EG10907-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10907-MONOMER BioCyc MetaCyc:EG10907-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10907-MONOMER COG COG0096 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0096 DIP DIP-47901N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47901N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1016/S0092-8674(03)00427-6 http://dx.doi.org/10.1016/S0092-8674(03)00427-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb841 http://dx.doi.org/10.1038/nsb841 DOI 10.1093/nar/11.9.2599 http://dx.doi.org/10.1093/nar/11.9.2599 DOI 10.1093/nar/9.7.1757 http://dx.doi.org/10.1093/nar/9.7.1757 DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB00759 http://www.drugbank.ca/drugs/DB00759 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X01563 http://www.ebi.ac.uk/ena/data/view/X01563 EchoBASE EB0900 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0900 EcoGene EG10907 http://www.ecogene.org/geneInfo.php?eg_id=EG10907 EnsemblBacteria AAC76331 http://www.ensemblgenomes.org/id/AAC76331 EnsemblBacteria AAC76331 http://www.ensemblgenomes.org/id/AAC76331 EnsemblBacteria BAE77985 http://www.ensemblgenomes.org/id/BAE77985 EnsemblBacteria BAE77985 http://www.ensemblgenomes.org/id/BAE77985 EnsemblBacteria BAE77985 http://www.ensemblgenomes.org/id/BAE77985 EnsemblBacteria b3306 http://www.ensemblgenomes.org/id/b3306 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0022627 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022627 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GO_process GO:0006417 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006417 GO_process GO:0043488 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043488 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 947802 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947802 HAMAP MF_01302_B http://hamap.expasy.org/unirule/MF_01302_B HOGENOM HOG000204095 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000204095&db=HOGENOM6 InParanoid P0A7W7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7W7 IntAct P0A7W7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7W7* InterPro IPR000630 http://www.ebi.ac.uk/interpro/entry/IPR000630 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW3268 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3268 KEGG_Gene eco:b3306 http://www.genome.jp/dbget-bin/www_bget?eco:b3306 KEGG_Orthology KO:K02994 http://www.genome.jp/dbget-bin/www_bget?KO:K02994 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 MINT MINT-1318565 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1318565 OMA RIYKNTR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RIYKNTR PANTHER PTHR11758 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11758 PDB 1EG0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1EG0 PDB 1M5G http://www.ebi.ac.uk/pdbe-srv/view/entry/1M5G PDB 1S03 http://www.ebi.ac.uk/pdbe-srv/view/entry/1S03 PDB 2YKR http://www.ebi.ac.uk/pdbe-srv/view/entry/2YKR PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 4A2I http://www.ebi.ac.uk/pdbe-srv/view/entry/4A2I PDB 4ADV http://www.ebi.ac.uk/pdbe-srv/view/entry/4ADV PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4V47 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V47 PDB 4V48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V48 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 1EG0 http://www.ebi.ac.uk/pdbsum/1EG0 PDBsum 1M5G http://www.ebi.ac.uk/pdbsum/1M5G PDBsum 1S03 http://www.ebi.ac.uk/pdbsum/1S03 PDBsum 2YKR http://www.ebi.ac.uk/pdbsum/2YKR PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 4A2I http://www.ebi.ac.uk/pdbsum/4A2I PDBsum 4ADV http://www.ebi.ac.uk/pdbsum/4ADV PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4V47 http://www.ebi.ac.uk/pdbsum/4V47 PDBsum 4V48 http://www.ebi.ac.uk/pdbsum/4V48 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PROSITE PS00053 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00053 PSORT swissprot:RS8_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RS8_ECOLI PSORT-B swissprot:RS8_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RS8_ECOLI PSORT2 swissprot:RS8_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RS8_ECOLI Pfam PF00410 http://pfam.xfam.org/family/PF00410 Phobius swissprot:RS8_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RS8_ECOLI PhylomeDB P0A7W7 http://phylomedb.org/?seqid=P0A7W7 ProteinModelPortal P0A7W7 http://www.proteinmodelportal.org/query/uniprot/P0A7W7 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 12244297 http://www.ncbi.nlm.nih.gov/pubmed/12244297 PubMed 12809609 http://www.ncbi.nlm.nih.gov/pubmed/12809609 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1735715 http://www.ncbi.nlm.nih.gov/pubmed/1735715 PubMed 365698 http://www.ncbi.nlm.nih.gov/pubmed/365698 PubMed 6222285 http://www.ncbi.nlm.nih.gov/pubmed/6222285 PubMed 6262737 http://www.ncbi.nlm.nih.gov/pubmed/6262737 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417765 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417765 RefSeq WP_000062611 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000062611 SMR P0A7W7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7W7 STRING 511145.b3306 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3306&targetmode=cogs STRING COG0096 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0096&targetmode=cogs SUPFAM SSF56047 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56047 UniProtKB RS8_ECOLI http://www.uniprot.org/uniprot/RS8_ECOLI UniProtKB-AC P0A7W7 http://www.uniprot.org/uniprot/P0A7W7 charge swissprot:RS8_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RS8_ECOLI eggNOG COG0096 http://eggnogapi.embl.de/nog_data/html/tree/COG0096 epestfind swissprot:RS8_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RS8_ECOLI garnier swissprot:RS8_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RS8_ECOLI helixturnhelix swissprot:RS8_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RS8_ECOLI hmoment swissprot:RS8_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RS8_ECOLI iep swissprot:RS8_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RS8_ECOLI inforesidue swissprot:RS8_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RS8_ECOLI octanol swissprot:RS8_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RS8_ECOLI pepcoil swissprot:RS8_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RS8_ECOLI pepdigest swissprot:RS8_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RS8_ECOLI pepinfo swissprot:RS8_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RS8_ECOLI pepnet swissprot:RS8_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RS8_ECOLI pepstats swissprot:RS8_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RS8_ECOLI pepwheel swissprot:RS8_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RS8_ECOLI pepwindow swissprot:RS8_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RS8_ECOLI sigcleave swissprot:RS8_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RS8_ECOLI ## Database ID URL or Descriptions # BioGrid 4261671 17 # EcoGene EG13698 ycaN # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0043565 sequence-specific DNA binding; IBA:GO_Central. # GO_process GO:0006351 transcription, DNA-templated; ISS:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR005119 LysR_subst-bd # InterPro IPR011991 WHTH_DNA-bd_dom # Organism YCAN_ECOLI Escherichia coli (strain K12) # PATRIC 32117013 VBIEscCol129921_0931 # PIR C64829 C64829 # PROSITE PS50931 HTH_LYSR # Pfam PF00126 HTH_1 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCAN_ECOLI Uncharacterized HTH-type transcriptional regulator YcaN # RefSeq NP_415420 NC_000913.3 # RefSeq WP_001242684 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lysR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00253}. # SUPFAM SSF46785 SSF46785 # eggNOG ENOG410642W Bacteria # eggNOG ENOG410XSPG LUCA BLAST swissprot:YCAN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCAN_ECOLI BioCyc ECOL316407:JW0883-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0883-MONOMER BioCyc EcoCyc:G6467-MONOMER http://biocyc.org/getid?id=EcoCyc:G6467-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3462 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3462 EcoGene EG13698 http://www.ecogene.org/geneInfo.php?eg_id=EG13698 EnsemblBacteria AAC73986 http://www.ensemblgenomes.org/id/AAC73986 EnsemblBacteria AAC73986 http://www.ensemblgenomes.org/id/AAC73986 EnsemblBacteria BAA35635 http://www.ensemblgenomes.org/id/BAA35635 EnsemblBacteria BAA35635 http://www.ensemblgenomes.org/id/BAA35635 EnsemblBacteria BAA35635 http://www.ensemblgenomes.org/id/BAA35635 EnsemblBacteria b0900 http://www.ensemblgenomes.org/id/b0900 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 945523 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945523 HOGENOM HOG000233519 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000233519&db=HOGENOM6 InParanoid P75836 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75836 InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW0883 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0883 KEGG_Gene eco:b0900 http://www.genome.jp/dbget-bin/www_bget?eco:b0900 OMA DWITERP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DWITERP PROSITE PS50931 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50931 PSORT swissprot:YCAN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCAN_ECOLI PSORT-B swissprot:YCAN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCAN_ECOLI PSORT2 swissprot:YCAN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCAN_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:YCAN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCAN_ECOLI PhylomeDB P75836 http://phylomedb.org/?seqid=P75836 ProteinModelPortal P75836 http://www.proteinmodelportal.org/query/uniprot/P75836 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415420 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415420 RefSeq WP_001242684 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001242684 SMR P75836 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75836 STRING 511145.b0900 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0900&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB YCAN_ECOLI http://www.uniprot.org/uniprot/YCAN_ECOLI UniProtKB-AC P75836 http://www.uniprot.org/uniprot/P75836 charge swissprot:YCAN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCAN_ECOLI eggNOG ENOG410642W http://eggnogapi.embl.de/nog_data/html/tree/ENOG410642W eggNOG ENOG410XSPG http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XSPG epestfind swissprot:YCAN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCAN_ECOLI garnier swissprot:YCAN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCAN_ECOLI helixturnhelix swissprot:YCAN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCAN_ECOLI hmoment swissprot:YCAN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCAN_ECOLI iep swissprot:YCAN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCAN_ECOLI inforesidue swissprot:YCAN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCAN_ECOLI octanol swissprot:YCAN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCAN_ECOLI pepcoil swissprot:YCAN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCAN_ECOLI pepdigest swissprot:YCAN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCAN_ECOLI pepinfo swissprot:YCAN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCAN_ECOLI pepnet swissprot:YCAN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCAN_ECOLI pepstats swissprot:YCAN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCAN_ECOLI pepwheel swissprot:YCAN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCAN_ECOLI pepwindow swissprot:YCAN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCAN_ECOLI sigcleave swissprot:YCAN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCAN_ECOLI ## Database ID URL or Descriptions # AltName FLMC1_ECOLI F-plasmid maintenance protein C # Organism FLMC1_ECOLI Escherichia coli (strain K12) # PIR JS0433 JS0433 # RecName FLMC1_ECOLI Protein FlmC # RefSeq NP_061444 NC_002483.1 # RefSeq WP_001306679 NC_002483.1 BLAST swissprot:FLMC1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLMC1_ECOLI DOI 10.1016/0378-1119(88)90362-9 http://dx.doi.org/10.1016/0378-1119(88)90362-9 EMBL AF106329 http://www.ebi.ac.uk/ena/data/view/AF106329 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1263583 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263583 OMA HVVNIHT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HVVNIHT PSORT swissprot:FLMC1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLMC1_ECOLI PSORT-B swissprot:FLMC1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLMC1_ECOLI PSORT2 swissprot:FLMC1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLMC1_ECOLI Phobius swissprot:FLMC1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLMC1_ECOLI ProteinModelPortal P11519 http://www.proteinmodelportal.org/query/uniprot/P11519 PubMed 3049248 http://www.ncbi.nlm.nih.gov/pubmed/3049248 RefSeq NP_061444 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061444 RefSeq WP_001306679 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001306679 UniProtKB FLMC1_ECOLI http://www.uniprot.org/uniprot/FLMC1_ECOLI UniProtKB-AC P11519 http://www.uniprot.org/uniprot/P11519 charge swissprot:FLMC1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLMC1_ECOLI epestfind swissprot:FLMC1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLMC1_ECOLI garnier swissprot:FLMC1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLMC1_ECOLI helixturnhelix swissprot:FLMC1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLMC1_ECOLI hmoment swissprot:FLMC1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLMC1_ECOLI iep swissprot:FLMC1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLMC1_ECOLI inforesidue swissprot:FLMC1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLMC1_ECOLI octanol swissprot:FLMC1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLMC1_ECOLI pepcoil swissprot:FLMC1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLMC1_ECOLI pepdigest swissprot:FLMC1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLMC1_ECOLI pepinfo swissprot:FLMC1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLMC1_ECOLI pepnet swissprot:FLMC1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLMC1_ECOLI pepstats swissprot:FLMC1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLMC1_ECOLI pepwheel swissprot:FLMC1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLMC1_ECOLI pepwindow swissprot:FLMC1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLMC1_ECOLI sigcleave swissprot:FLMC1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLMC1_ECOLI ## Database ID URL or Descriptions # BioGrid 4262066 5 # EcoGene EG12537 yjgR # Gene3D 3.40.50.300 -; 2. # IntAct P39342 4 # InterPro IPR027417 P-loop_NTPase # InterPro IPR033186 HerA_C # Organism YJGR_ECOLI Escherichia coli (strain K12) # PATRIC 32124099 VBIEscCol129921_4394 # PIR S56489 S56489 # Pfam PF05872 DUF853 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJGR_ECOLI Uncharacterized protein YjgR # RefSeq NP_418684 NC_000913.3 # RefSeq WP_001294573 NZ_CP014272.1 # SIMILARITY To E.coli YjiB. {ECO 0000305}. # SUPFAM SSF52540 SSF52540 # eggNOG COG0433 LUCA # eggNOG ENOG4105D7A Bacteria BLAST swissprot:YJGR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJGR_ECOLI BioCyc ECOL316407:JW4220-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4220-MONOMER BioCyc EcoCyc:G7890-MONOMER http://biocyc.org/getid?id=EcoCyc:G7890-MONOMER COG COG0433 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0433 DIP DIP-12612N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12612N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2426 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2426 EcoGene EG12537 http://www.ecogene.org/geneInfo.php?eg_id=EG12537 EnsemblBacteria AAC77220 http://www.ensemblgenomes.org/id/AAC77220 EnsemblBacteria AAC77220 http://www.ensemblgenomes.org/id/AAC77220 EnsemblBacteria BAE78260 http://www.ensemblgenomes.org/id/BAE78260 EnsemblBacteria BAE78260 http://www.ensemblgenomes.org/id/BAE78260 EnsemblBacteria BAE78260 http://www.ensemblgenomes.org/id/BAE78260 EnsemblBacteria b4263 http://www.ensemblgenomes.org/id/b4263 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948978 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948978 HOGENOM HOG000252419 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000252419&db=HOGENOM6 InParanoid P39342 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39342 IntAct P39342 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39342* InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR033186 http://www.ebi.ac.uk/interpro/entry/IPR033186 KEGG_Gene ecj:JW4220 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4220 KEGG_Gene eco:b4263 http://www.genome.jp/dbget-bin/www_bget?eco:b4263 KEGG_Orthology KO:K06915 http://www.genome.jp/dbget-bin/www_bget?KO:K06915 OMA VSEMGPL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VSEMGPL PSORT swissprot:YJGR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJGR_ECOLI PSORT-B swissprot:YJGR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJGR_ECOLI PSORT2 swissprot:YJGR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJGR_ECOLI Pfam PF05872 http://pfam.xfam.org/family/PF05872 Phobius swissprot:YJGR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJGR_ECOLI PhylomeDB P39342 http://phylomedb.org/?seqid=P39342 ProteinModelPortal P39342 http://www.proteinmodelportal.org/query/uniprot/P39342 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418684 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418684 RefSeq WP_001294573 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001294573 SMR P39342 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39342 STRING 511145.b4263 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4263&targetmode=cogs STRING COG0433 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0433&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB YJGR_ECOLI http://www.uniprot.org/uniprot/YJGR_ECOLI UniProtKB-AC P39342 http://www.uniprot.org/uniprot/P39342 charge swissprot:YJGR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJGR_ECOLI eggNOG COG0433 http://eggnogapi.embl.de/nog_data/html/tree/COG0433 eggNOG ENOG4105D7A http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D7A epestfind swissprot:YJGR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJGR_ECOLI garnier swissprot:YJGR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJGR_ECOLI helixturnhelix swissprot:YJGR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJGR_ECOLI hmoment swissprot:YJGR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJGR_ECOLI iep swissprot:YJGR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJGR_ECOLI inforesidue swissprot:YJGR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJGR_ECOLI octanol swissprot:YJGR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJGR_ECOLI pepcoil swissprot:YJGR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJGR_ECOLI pepdigest swissprot:YJGR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJGR_ECOLI pepinfo swissprot:YJGR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJGR_ECOLI pepnet swissprot:YJGR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJGR_ECOLI pepstats swissprot:YJGR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJGR_ECOLI pepwheel swissprot:YJGR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJGR_ECOLI pepwindow swissprot:YJGR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJGR_ECOLI sigcleave swissprot:YJGR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJGR_ECOLI ## Database ID URL or Descriptions # AltName GUAC_ECOLI Guanosine 5'-monophosphate oxidoreductase # BioGrid 4261108 10 # CATALYTIC ACTIVITY GUAC_ECOLI Inosine 5'-phosphate + NH(3) + NADP(+) = guanosine 5'-phosphate + NADPH. # CDD cd00381 IMPDH # EcoGene EG10422 guaC # FUNCTION GUAC_ECOLI Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:1902560 GMP reductase complex; IEA:UniProtKB-EC. # GO_function GO:0003920 GMP reductase activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0015951 purine ribonucleotide interconversion; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.70 -; 1. # HAMAP MF_00596 GMP_reduct_type1 # INTERACTION GUAC_ECOLI P15034 pepP; NbExp=2; IntAct=EBI-544491, EBI-554801; # IntAct P60560 6 # InterPro IPR001093 IMP_DH_GMPRt # InterPro IPR005993 GMPR # InterPro IPR013785 Aldolase_TIM # InterPro IPR015875 IMP_DH/GMP_Rdtase_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # Organism GUAC_ECOLI Escherichia coli (strain K12) # PATRIC 32115311 VBIEscCol129921_0107 # PIR H64732 H64732 # PIRSF PIRSF000235 GMP_reductase # PROSITE PS00487 IMP_DH_GMP_RED # Pfam PF00478 IMPDH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GUAC_ECOLI GMP reductase # RefSeq NP_414646 NC_000913.3 # RefSeq WP_001217338 NZ_LN832404.1 # SIMILARITY Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily. {ECO 0000305}. # SUBUNIT GUAC_ECOLI Homotetramer. # TIGRFAMs TIGR01305 GMP_reduct_1 # eggNOG COG0516 LUCA # eggNOG ENOG4105CP4 Bacteria BLAST swissprot:GUAC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GUAC_ECOLI BioCyc ECOL316407:JW0101-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0101-MONOMER BioCyc EcoCyc:GMP-REDUCT-MONOMER http://biocyc.org/getid?id=EcoCyc:GMP-REDUCT-MONOMER BioCyc MetaCyc:GMP-REDUCT-MONOMER http://biocyc.org/getid?id=MetaCyc:GMP-REDUCT-MONOMER COG COG0516 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0516 DIP DIP-47861N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47861N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1016/0378-1119(94)90851-6 http://dx.doi.org/10.1016/0378-1119(94)90851-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2550035 http://dx.doi.org/10.1042/bj2550035 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.7.1.7 http://www.genome.jp/dbget-bin/www_bget?EC:1.7.1.7 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L28105 http://www.ebi.ac.uk/ena/data/view/L28105 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X07917 http://www.ebi.ac.uk/ena/data/view/X07917 ENZYME 1.7.1.7 http://enzyme.expasy.org/EC/1.7.1.7 EchoBASE EB0417 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0417 EcoGene EG10422 http://www.ecogene.org/geneInfo.php?eg_id=EG10422 EnsemblBacteria AAC73215 http://www.ensemblgenomes.org/id/AAC73215 EnsemblBacteria AAC73215 http://www.ensemblgenomes.org/id/AAC73215 EnsemblBacteria BAB96673 http://www.ensemblgenomes.org/id/BAB96673 EnsemblBacteria BAB96673 http://www.ensemblgenomes.org/id/BAB96673 EnsemblBacteria BAB96673 http://www.ensemblgenomes.org/id/BAB96673 EnsemblBacteria b0104 http://www.ensemblgenomes.org/id/b0104 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:1902560 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902560 GO_function GO:0003920 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003920 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0015951 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015951 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 948986 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948986 HAMAP MF_00596 http://hamap.expasy.org/unirule/MF_00596 HOGENOM HOG000165756 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000165756&db=HOGENOM6 InParanoid P60560 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P60560 IntAct P60560 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P60560* IntEnz 1.7.1.7 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.7.1.7 InterPro IPR001093 http://www.ebi.ac.uk/interpro/entry/IPR001093 InterPro IPR005993 http://www.ebi.ac.uk/interpro/entry/IPR005993 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR015875 http://www.ebi.ac.uk/interpro/entry/IPR015875 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0101 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0101 KEGG_Gene eco:b0104 http://www.genome.jp/dbget-bin/www_bget?eco:b0104 KEGG_Orthology KO:K00364 http://www.genome.jp/dbget-bin/www_bget?KO:K00364 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Reaction rn:R01134 http://www.genome.jp/dbget-bin/www_bget?rn:R01134 MINT MINT-1311378 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1311378 OMA CSCAGDV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CSCAGDV PROSITE PS00487 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00487 PSORT swissprot:GUAC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GUAC_ECOLI PSORT-B swissprot:GUAC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GUAC_ECOLI PSORT2 swissprot:GUAC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GUAC_ECOLI Pfam PF00478 http://pfam.xfam.org/family/PF00478 Phobius swissprot:GUAC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GUAC_ECOLI PhylomeDB P60560 http://phylomedb.org/?seqid=P60560 ProteinModelPortal P60560 http://www.proteinmodelportal.org/query/uniprot/P60560 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2904262 http://www.ncbi.nlm.nih.gov/pubmed/2904262 PubMed 7959070 http://www.ncbi.nlm.nih.gov/pubmed/7959070 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_414646 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414646 RefSeq WP_001217338 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001217338 SMR P60560 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P60560 STRING 511145.b0104 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0104&targetmode=cogs STRING COG0516 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0516&targetmode=cogs TIGRFAMs TIGR01305 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01305 UniProtKB GUAC_ECOLI http://www.uniprot.org/uniprot/GUAC_ECOLI UniProtKB-AC P60560 http://www.uniprot.org/uniprot/P60560 charge swissprot:GUAC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GUAC_ECOLI eggNOG COG0516 http://eggnogapi.embl.de/nog_data/html/tree/COG0516 eggNOG ENOG4105CP4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CP4 epestfind swissprot:GUAC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GUAC_ECOLI garnier swissprot:GUAC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GUAC_ECOLI helixturnhelix swissprot:GUAC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GUAC_ECOLI hmoment swissprot:GUAC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GUAC_ECOLI iep swissprot:GUAC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GUAC_ECOLI inforesidue swissprot:GUAC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GUAC_ECOLI octanol swissprot:GUAC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GUAC_ECOLI pepcoil swissprot:GUAC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GUAC_ECOLI pepdigest swissprot:GUAC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GUAC_ECOLI pepinfo swissprot:GUAC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GUAC_ECOLI pepnet swissprot:GUAC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GUAC_ECOLI pepstats swissprot:GUAC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GUAC_ECOLI pepwheel swissprot:GUAC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GUAC_ECOLI pepwindow swissprot:GUAC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GUAC_ECOLI sigcleave swissprot:GUAC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GUAC_ECOLI ## Database ID URL or Descriptions # AltName GALF_ECOLI Alpha-D-glucosyl-1-phosphate uridylyltransferase # AltName GALF_ECOLI UDP-glucose pyrophosphorylase # AltName GALF_ECOLI Uridine diphosphoglucose pyrophosphorylase # BioGrid 4259678 176 # CATALYTIC ACTIVITY GALF_ECOLI UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose. # EcoGene EG13578 galF # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GALF_ECOLI GO 0003983 UTP glucose-1-phosphate uridylyltransferase activity; IEA UniProtKB-EC. # GO_function GO:0030234 enzyme regulator activity; IEA:InterPro. # GO_process GO:0006011 UDP-glucose metabolic process; IEA:InterPro. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0030234 enzyme regulator activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.90.550.10 -; 1. # IntAct P0AAB6 17 # InterPro IPR005774 GalF # InterPro IPR005835 NTP_transferase_dom # InterPro IPR029044 Nucleotide-diphossugar_trans # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00040 Pentose and glucuronate interconversions # KEGG_Pathway ko00052 Galactose metabolism # KEGG_Pathway ko00500 Starch and sucrose metabolism # KEGG_Pathway ko00520 Amino sugar and nucleotide sugar metabolism # Organism GALF_ECOLI Escherichia coli (strain K12) # PATHWAY GALF_ECOLI Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. # PATHWAY GALF_ECOLI Carbohydrate metabolism; nucleotide-sugar metabolism. # PATRIC 32119417 VBIEscCol129921_2119 # PIR A64970 A64970 # Pfam PF00483 NTP_transferase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GALF_ECOLI UTP--glucose-1-phosphate uridylyltransferase # RefSeq NP_416546 NC_000913.3 # RefSeq WP_000183060 NZ_LN832404.1 # SIMILARITY Belongs to the UDPGP type 2 family. {ECO 0000305}. # SUPFAM SSF53448 SSF53448 # TIGRFAMs TIGR01105 galF # eggNOG COG1210 LUCA # eggNOG ENOG4105C3Y Bacteria BLAST swissprot:GALF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GALF_ECOLI BioCyc ECOL316407:JW2027-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2027-MONOMER BioCyc EcoCyc:G7093-MONOMER http://biocyc.org/getid?id=EcoCyc:G7093-MONOMER COG COG1210 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1210 DIP DIP-35871N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35871N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1996.01531.x http://dx.doi.org/10.1046/j.1365-2958.1996.01531.x DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.7.9 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.9 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U38473 http://www.ebi.ac.uk/ena/data/view/U38473 ENZYME 2.7.7.9 http://enzyme.expasy.org/EC/2.7.7.9 EchoBASE EB3348 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3348 EcoGene EG13578 http://www.ecogene.org/geneInfo.php?eg_id=EG13578 EnsemblBacteria AAC75103 http://www.ensemblgenomes.org/id/AAC75103 EnsemblBacteria AAC75103 http://www.ensemblgenomes.org/id/AAC75103 EnsemblBacteria BAA15896 http://www.ensemblgenomes.org/id/BAA15896 EnsemblBacteria BAA15896 http://www.ensemblgenomes.org/id/BAA15896 EnsemblBacteria BAA15896 http://www.ensemblgenomes.org/id/BAA15896 EnsemblBacteria b2042 http://www.ensemblgenomes.org/id/b2042 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003983 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003983 GO_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 GO_process GO:0006011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006011 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.90.550.10 http://www.cathdb.info/version/latest/superfamily/3.90.550.10 GeneID 946560 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946560 HOGENOM HOG000283477 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000283477&db=HOGENOM6 InParanoid P0AAB6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAB6 IntAct P0AAB6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAB6* IntEnz 2.7.7.9 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.9 InterPro IPR005774 http://www.ebi.ac.uk/interpro/entry/IPR005774 InterPro IPR005835 http://www.ebi.ac.uk/interpro/entry/IPR005835 InterPro IPR029044 http://www.ebi.ac.uk/interpro/entry/IPR029044 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2027 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2027 KEGG_Gene eco:b2042 http://www.genome.jp/dbget-bin/www_bget?eco:b2042 KEGG_Orthology KO:K00963 http://www.genome.jp/dbget-bin/www_bget?KO:K00963 KEGG_Pathway ko00040 http://www.genome.jp/kegg-bin/show_pathway?ko00040 KEGG_Pathway ko00052 http://www.genome.jp/kegg-bin/show_pathway?ko00052 KEGG_Pathway ko00500 http://www.genome.jp/kegg-bin/show_pathway?ko00500 KEGG_Pathway ko00520 http://www.genome.jp/kegg-bin/show_pathway?ko00520 KEGG_Reaction rn:R00289 http://www.genome.jp/dbget-bin/www_bget?rn:R00289 OMA KTAPGAW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KTAPGAW PSORT swissprot:GALF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GALF_ECOLI PSORT-B swissprot:GALF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GALF_ECOLI PSORT2 swissprot:GALF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GALF_ECOLI Pfam PF00483 http://pfam.xfam.org/family/PF00483 Phobius swissprot:GALF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GALF_ECOLI PhylomeDB P0AAB6 http://phylomedb.org/?seqid=P0AAB6 ProteinModelPortal P0AAB6 http://www.proteinmodelportal.org/query/uniprot/P0AAB6 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8971705 http://www.ncbi.nlm.nih.gov/pubmed/8971705 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416546 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416546 RefSeq WP_000183060 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000183060 SMR P0AAB6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAB6 STRING 511145.b2042 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2042&targetmode=cogs STRING COG1210 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1210&targetmode=cogs SUPFAM SSF53448 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53448 TIGRFAMs TIGR01105 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01105 UniProtKB GALF_ECOLI http://www.uniprot.org/uniprot/GALF_ECOLI UniProtKB-AC P0AAB6 http://www.uniprot.org/uniprot/P0AAB6 charge swissprot:GALF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GALF_ECOLI eggNOG COG1210 http://eggnogapi.embl.de/nog_data/html/tree/COG1210 eggNOG ENOG4105C3Y http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C3Y epestfind swissprot:GALF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GALF_ECOLI garnier swissprot:GALF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GALF_ECOLI helixturnhelix swissprot:GALF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GALF_ECOLI hmoment swissprot:GALF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GALF_ECOLI iep swissprot:GALF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GALF_ECOLI inforesidue swissprot:GALF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GALF_ECOLI octanol swissprot:GALF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GALF_ECOLI pepcoil swissprot:GALF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GALF_ECOLI pepdigest swissprot:GALF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GALF_ECOLI pepinfo swissprot:GALF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GALF_ECOLI pepnet swissprot:GALF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GALF_ECOLI pepstats swissprot:GALF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GALF_ECOLI pepwheel swissprot:GALF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GALF_ECOLI pepwindow swissprot:GALF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GALF_ECOLI sigcleave swissprot:GALF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GALF_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES OXC_ECOLI Kinetic parameters KM=3.17 uM for oxalyl-CoA (with 300 uM ADP at pH 6.5 and 30 degrees Celsius) {ECO 0000269|PubMed 20553497}; KM=4.8 uM for oxalyl-CoA (at pH 6.5 and 30 degrees Celsius) {ECO 0000269|PubMed 20553497}; Note=Kcat is 69.7 sec(-1) for decarboxylase activity with oxalyl-CoA as substrate (with 300 uM ADP at pH 6.5 and 30 degrees Celsius). Kcat is 60.7 sec(-1) for decarboxylase activity with oxalyl-CoA as substrate (at pH 6.5 and 30 degrees Celsius).; pH dependence Optimum pH is between 5.5 and 7. {ECO 0000269|PubMed 20553497}; # BRENDA 4.1.1 2026 # BioGrid 4260862 15 # CATALYTIC ACTIVITY Oxalyl-CoA = formyl-CoA + CO(2). {ECO:0000269|PubMed 20553497}. # COFACTOR OXC_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 20553497}; Note=Binds 1 Mg(2+) ion per subunit. {ECO 0000269|PubMed 20553497}; # COFACTOR OXC_ECOLI Name=thiamine diphosphate; Xref=ChEBI CHEBI 58937; Evidence={ECO 0000269|PubMed 20553497}; Note=Binds 1 thiamine pyrophosphate per subunit. {ECO 0000269|PubMed 20553497}; # ENZYME REGULATION Activated by ADP. {ECO:0000269|PubMed 20553497}. # EcoGene EG14143 oxc # FUNCTION OXC_ECOLI Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the decarboxylation of oxalyl-CoA to yield carbon dioxide and formyl-CoA. {ECO 0000269|PubMed 20553497}. # GO_function GO:0000287 magnesium ion binding; IDA:UniProtKB. # GO_function GO:0008949 oxalyl-CoA decarboxylase activity; IDA:EcoCyc. # GO_function GO:0030976 thiamine pyrophosphate binding; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IPI:IntAct. # GO_function GO:0043531 ADP binding; IDA:EcoCyc. # GO_process GO:0033611 oxalate catabolic process; IDA:UniProtKB. # GO_process GO:0071468 cellular response to acidic pH; IMP:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.1220 -; 1. # Gene3D 3.40.50.970 -; 2. # INDUCTION By the acid response regulator EvgA. {ECO:0000269|PubMed 23335415}. # INTERACTION OXC_ECOLI Self; NbExp=4; IntAct=EBI-557143, EBI-557143; # IntAct P0AFI0 6 # InterPro IPR011766 TPP_enzyme-bd_C # InterPro IPR012000 Thiamin_PyroP_enz_cen_dom # InterPro IPR012001 Thiamin_PyroP_enz_TPP-bd_dom # InterPro IPR017660 Oxalyl-CoA_decarboxylase # InterPro IPR029035 DHS-like_NAD/FAD-binding_dom # InterPro IPR029061 THDP-binding # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00630 Glyoxylate and dicarboxylate metabolism # Organism OXC_ECOLI Escherichia coli (strain K12) # PATHWAY Metabolic intermediate degradation; oxalate degradation; CO(2) and formate from oxalate step 2/2. # PATRIC 32120125 VBIEscCol129921_2471 # PDB 2Q27 X-ray; 2.12 A; A/B=1-564 # PDB 2Q28 X-ray; 1.74 A; A/B=1-564 # PDB 2Q29 X-ray; 1.82 A; A/B=1-564 # PIR B65011 B65011 # Pfam PF00205 TPP_enzyme_M # Pfam PF02775 TPP_enzyme_C # Pfam PF02776 TPP_enzyme_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName OXC_ECOLI Oxalyl-CoA decarboxylase # RefSeq NP_416874 NC_000913.3 # RefSeq WP_001283490 NZ_LN832404.1 # SIMILARITY Belongs to the TPP enzyme family. {ECO 0000305}. # SUBUNIT Homotetramer; dimer of dimers. {ECO:0000269|PubMed 20553497}. # SUPFAM SSF52467 SSF52467 # SUPFAM SSF52518 SSF52518; 2 # TIGRFAMs TIGR03254 oxalate_oxc # UniPathway UPA00540 UER00599 # eggNOG COG0028 LUCA # eggNOG ENOG4105CFN Bacteria BLAST swissprot:OXC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:OXC_ECOLI BioCyc ECOL316407:JW2370-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2370-MONOMER BioCyc EcoCyc:G7236-MONOMER http://biocyc.org/getid?id=EcoCyc:G7236-MONOMER BioCyc MetaCyc:G7236-MONOMER http://biocyc.org/getid?id=MetaCyc:G7236-MONOMER COG COG0028 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0028 DIP DIP-48075N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48075N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1742-4658.2010.07673.x http://dx.doi.org/10.1111/j.1742-4658.2010.07673.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01936-12 http://dx.doi.org/10.1128/JB.01936-12 EC_number EC:4.1.1.8 http://www.genome.jp/dbget-bin/www_bget?EC:4.1.1.8 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 4.1.1.8 http://enzyme.expasy.org/EC/4.1.1.8 EchoBASE EB3895 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3895 EcoGene EG14143 http://www.ecogene.org/geneInfo.php?eg_id=EG14143 EnsemblBacteria AAC75432 http://www.ensemblgenomes.org/id/AAC75432 EnsemblBacteria AAC75432 http://www.ensemblgenomes.org/id/AAC75432 EnsemblBacteria BAA16245 http://www.ensemblgenomes.org/id/BAA16245 EnsemblBacteria BAA16245 http://www.ensemblgenomes.org/id/BAA16245 EnsemblBacteria BAA16245 http://www.ensemblgenomes.org/id/BAA16245 EnsemblBacteria b2373 http://www.ensemblgenomes.org/id/b2373 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0008949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008949 GO_function GO:0030976 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030976 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0043531 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043531 GO_process GO:0033611 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033611 GO_process GO:0071468 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071468 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.1220 http://www.cathdb.info/version/latest/superfamily/3.40.50.1220 Gene3D 3.40.50.970 http://www.cathdb.info/version/latest/superfamily/3.40.50.970 GeneID 946845 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946845 HOGENOM HOG000053808 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000053808&db=HOGENOM6 InParanoid P0AFI0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFI0 IntAct P0AFI0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFI0* IntEnz 4.1.1.8 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.1.8 InterPro IPR011766 http://www.ebi.ac.uk/interpro/entry/IPR011766 InterPro IPR012000 http://www.ebi.ac.uk/interpro/entry/IPR012000 InterPro IPR012001 http://www.ebi.ac.uk/interpro/entry/IPR012001 InterPro IPR017660 http://www.ebi.ac.uk/interpro/entry/IPR017660 InterPro IPR029035 http://www.ebi.ac.uk/interpro/entry/IPR029035 InterPro IPR029061 http://www.ebi.ac.uk/interpro/entry/IPR029061 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2370 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2370 KEGG_Gene eco:b2373 http://www.genome.jp/dbget-bin/www_bget?eco:b2373 KEGG_Orthology KO:K01577 http://www.genome.jp/dbget-bin/www_bget?KO:K01577 KEGG_Pathway ko00630 http://www.genome.jp/kegg-bin/show_pathway?ko00630 KEGG_Reaction rn:R01908 http://www.genome.jp/dbget-bin/www_bget?rn:R01908 MINT MINT-7717811 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-7717811 OMA FRHEQHA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FRHEQHA PDB 2Q27 http://www.ebi.ac.uk/pdbe-srv/view/entry/2Q27 PDB 2Q28 http://www.ebi.ac.uk/pdbe-srv/view/entry/2Q28 PDB 2Q29 http://www.ebi.ac.uk/pdbe-srv/view/entry/2Q29 PDBsum 2Q27 http://www.ebi.ac.uk/pdbsum/2Q27 PDBsum 2Q28 http://www.ebi.ac.uk/pdbsum/2Q28 PDBsum 2Q29 http://www.ebi.ac.uk/pdbsum/2Q29 PSORT swissprot:OXC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:OXC_ECOLI PSORT-B swissprot:OXC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:OXC_ECOLI PSORT2 swissprot:OXC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:OXC_ECOLI Pfam PF00205 http://pfam.xfam.org/family/PF00205 Pfam PF02775 http://pfam.xfam.org/family/PF02775 Pfam PF02776 http://pfam.xfam.org/family/PF02776 Phobius swissprot:OXC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:OXC_ECOLI PhylomeDB P0AFI0 http://phylomedb.org/?seqid=P0AFI0 ProteinModelPortal P0AFI0 http://www.proteinmodelportal.org/query/uniprot/P0AFI0 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20553497 http://www.ncbi.nlm.nih.gov/pubmed/20553497 PubMed 23335415 http://www.ncbi.nlm.nih.gov/pubmed/23335415 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416874 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416874 RefSeq WP_001283490 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001283490 SMR P0AFI0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFI0 STRING 511145.b2373 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2373&targetmode=cogs STRING COG0028 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0028&targetmode=cogs SUPFAM SSF52467 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52467 SUPFAM SSF52518 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52518 TIGRFAMs TIGR03254 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03254 UniProtKB OXC_ECOLI http://www.uniprot.org/uniprot/OXC_ECOLI UniProtKB-AC P0AFI0 http://www.uniprot.org/uniprot/P0AFI0 charge swissprot:OXC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:OXC_ECOLI eggNOG COG0028 http://eggnogapi.embl.de/nog_data/html/tree/COG0028 eggNOG ENOG4105CFN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CFN epestfind swissprot:OXC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:OXC_ECOLI garnier swissprot:OXC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:OXC_ECOLI helixturnhelix swissprot:OXC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:OXC_ECOLI hmoment swissprot:OXC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:OXC_ECOLI iep swissprot:OXC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:OXC_ECOLI inforesidue swissprot:OXC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:OXC_ECOLI octanol swissprot:OXC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:OXC_ECOLI pepcoil swissprot:OXC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:OXC_ECOLI pepdigest swissprot:OXC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:OXC_ECOLI pepinfo swissprot:OXC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:OXC_ECOLI pepnet swissprot:OXC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:OXC_ECOLI pepstats swissprot:OXC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:OXC_ECOLI pepwheel swissprot:OXC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:OXC_ECOLI pepwindow swissprot:OXC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:OXC_ECOLI sigcleave swissprot:OXC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:OXC_ECOLI ## Database ID URL or Descriptions # BioGrid 4261016 167 # CATALYTIC ACTIVITY Hydrolysis of (1->4)-beta-linkages between N- acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. {ECO:0000269|PubMed 10760150}. # CATALYTIC ACTIVITY Random hydrolysis of N-acetyl-beta-D- glucosaminide (1->4)-beta-linkages in chitin and chitodextrins. {ECO:0000269|PubMed 10760150}. # CAZy CBM5 Carbohydrate-Binding Module Family 5 # CAZy GH18 Glycoside Hydrolase Family 18 # EcoGene EG11237 chiA # FUNCTION CHIA_ECOLI Bifunctional enzyme with lysozyme/chitinase activity. {ECO 0000269|PubMed 10760150}. # GO_component GO:0005576 extracellular region; IEA:InterPro. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_component GO:0042597 periplasmic space; IDA:EcoCyc. # GO_function GO:0003796 lysozyme activity; IEA:UniProtKB-EC. # GO_function GO:0008061 chitin binding; IEA:UniProtKB-KW. # GO_function GO:0008843 endochitinase activity; IDA:EcoCyc. # GO_function GO:0030246 carbohydrate binding; IEA:InterPro. # GO_process GO:0000272 polysaccharide catabolic process; IEA:UniProtKB-KW. # GO_process GO:0006032 chitin catabolic process; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005576 extracellular region # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # Gene3D 2.10.10.20 -; 1. # Gene3D 3.20.20.80 -; 1. # INDUCTION Silenced by the DNA-binding protein H-NS under standard growth conditions. {ECO:0000269|PubMed 10760150}. # InterPro IPR003610 CBM_fam5/12 # InterPro IPR013781 Glyco_hydro_catalytic_dom # InterPro IPR017853 Glycoside_hydrolase_SF # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00520 Amino sugar and nucleotide sugar metabolism # Organism CHIA_ECOLI Escherichia coli (strain K12) # PATRIC 32122108 VBIEscCol129921_3431 # PIR E65127 E65127 # Pfam PF02839 CBM_5_12 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CHIA_ECOLI Chitinase # RecName CHIA_ECOLI Lysozyme # RecName CHIA_ECOLI Probable bifunctional chitinase/lysozyme # RecName CHIA_ECOLI Probable bifunctional chitinase/lysozyme # RefSeq NP_417797 NC_000913.3 # RefSeq WP_000773156 NZ_LN832404.1 # SIMILARITY Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily. {ECO 0000305}. # SIMILARITY Contains 5 chitin-binding type-3 domains. {ECO 0000305}. # SMART SM00495 ChtBD3; 7 # SUBCELLULAR LOCATION CHIA_ECOLI Periplasm {ECO 0000269|PubMed 10760150}. Note=Secreted via the Gsp type II secretion machinery under conditions of derepressed gsp gene expression. # SUPFAM SSF51055 SSF51055 # SUPFAM SSF51445 SSF51445 # eggNOG ENOG4108NNZ Bacteria # eggNOG ENOG4111APV LUCA BLAST swissprot:CHIA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CHIA_ECOLI BioCyc ECOL316407:JW3300-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3300-MONOMER BioCyc EcoCyc:EG11237-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11237-MONOMER BioCyc MetaCyc:EG11237-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11237-MONOMER DIP DIP-9276N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9276N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2000.01817.x http://dx.doi.org/10.1046/j.1365-2958.2000.01817.x DOI 10.1093/emboj/19.24.6697 http://dx.doi.org/10.1093/emboj/19.24.6697 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.2.1.14 http://www.genome.jp/dbget-bin/www_bget?EC:3.2.1.14 EC_number EC:3.2.1.17 http://www.genome.jp/dbget-bin/www_bget?EC:3.2.1.17 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M27176 http://www.ebi.ac.uk/ena/data/view/M27176 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 3.2.1.14 http://enzyme.expasy.org/EC/3.2.1.14 ENZYME 3.2.1.17 http://enzyme.expasy.org/EC/3.2.1.17 EchoBASE EB1219 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1219 EcoGene EG11237 http://www.ecogene.org/geneInfo.php?eg_id=EG11237 EnsemblBacteria AAC76363 http://www.ensemblgenomes.org/id/AAC76363 EnsemblBacteria AAC76363 http://www.ensemblgenomes.org/id/AAC76363 EnsemblBacteria BAE77953 http://www.ensemblgenomes.org/id/BAE77953 EnsemblBacteria BAE77953 http://www.ensemblgenomes.org/id/BAE77953 EnsemblBacteria BAE77953 http://www.ensemblgenomes.org/id/BAE77953 EnsemblBacteria b3338 http://www.ensemblgenomes.org/id/b3338 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005576 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576 GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0003796 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003796 GO_function GO:0008061 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008061 GO_function GO:0008843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008843 GO_function GO:0030246 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030246 GO_process GO:0000272 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000272 GO_process GO:0006032 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006032 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005576 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 2.10.10.20 http://www.cathdb.info/version/latest/superfamily/2.10.10.20 Gene3D 3.20.20.80 http://www.cathdb.info/version/latest/superfamily/3.20.20.80 GeneID 947837 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947837 HOGENOM HOG000125409 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125409&db=HOGENOM6 InParanoid P13656 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P13656 IntAct P13656 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P13656* IntEnz 3.2.1.14 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.2.1.14 IntEnz 3.2.1.17 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.2.1.17 InterPro IPR003610 http://www.ebi.ac.uk/interpro/entry/IPR003610 InterPro IPR013781 http://www.ebi.ac.uk/interpro/entry/IPR013781 InterPro IPR017853 http://www.ebi.ac.uk/interpro/entry/IPR017853 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3300 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3300 KEGG_Gene eco:b3338 http://www.genome.jp/dbget-bin/www_bget?eco:b3338 KEGG_Orthology KO:K13381 http://www.genome.jp/dbget-bin/www_bget?KO:K13381 KEGG_Pathway ko00520 http://www.genome.jp/kegg-bin/show_pathway?ko00520 KEGG_Reaction rn:R01206 http://www.genome.jp/dbget-bin/www_bget?rn:R01206 KEGG_Reaction rn:R02334 http://www.genome.jp/dbget-bin/www_bget?rn:R02334 OMA MIGYNDV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MIGYNDV PSORT swissprot:CHIA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CHIA_ECOLI PSORT-B swissprot:CHIA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CHIA_ECOLI PSORT2 swissprot:CHIA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CHIA_ECOLI Pfam PF02839 http://pfam.xfam.org/family/PF02839 Phobius swissprot:CHIA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CHIA_ECOLI ProteinModelPortal P13656 http://www.proteinmodelportal.org/query/uniprot/P13656 PubMed 10419961 http://www.ncbi.nlm.nih.gov/pubmed/10419961 PubMed 10760150 http://www.ncbi.nlm.nih.gov/pubmed/10760150 PubMed 11118204 http://www.ncbi.nlm.nih.gov/pubmed/11118204 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2661540 http://www.ncbi.nlm.nih.gov/pubmed/2661540 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417797 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417797 RefSeq WP_000773156 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000773156 SMART SM00495 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00495 SMR P13656 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P13656 STRING 511145.b3338 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3338&targetmode=cogs SUPFAM SSF51055 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51055 SUPFAM SSF51445 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51445 UniProtKB CHIA_ECOLI http://www.uniprot.org/uniprot/CHIA_ECOLI UniProtKB-AC P13656 http://www.uniprot.org/uniprot/P13656 charge swissprot:CHIA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CHIA_ECOLI eggNOG ENOG4108NNZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108NNZ eggNOG ENOG4111APV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111APV epestfind swissprot:CHIA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CHIA_ECOLI garnier swissprot:CHIA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CHIA_ECOLI helixturnhelix swissprot:CHIA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CHIA_ECOLI hmoment swissprot:CHIA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CHIA_ECOLI iep swissprot:CHIA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CHIA_ECOLI inforesidue swissprot:CHIA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CHIA_ECOLI octanol swissprot:CHIA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CHIA_ECOLI pepcoil swissprot:CHIA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CHIA_ECOLI pepdigest swissprot:CHIA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CHIA_ECOLI pepinfo swissprot:CHIA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CHIA_ECOLI pepnet swissprot:CHIA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CHIA_ECOLI pepstats swissprot:CHIA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CHIA_ECOLI pepwheel swissprot:CHIA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CHIA_ECOLI pepwindow swissprot:CHIA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CHIA_ECOLI sigcleave swissprot:CHIA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CHIA_ECOLI ## Database ID URL or Descriptions # AltName FDNG_ECOLI Anaerobic formate dehydrogenase major subunit # AltName FDNG_ECOLI Formate dehydrogenase-N subunit alpha # BRENDA 1.1.5 2026 # BioGrid 4262900 4 # CATALYTIC ACTIVITY Formate + a quinone = CO(2) + a quinol. {ECO:0000269|PubMed 11884747}. # COFACTOR FDNG_ECOLI Name=Mo-bis(molybdopterin guanine dinucleotide); Xref=ChEBI CHEBI 60539; Evidence={ECO 0000269|PubMed 11884747}; Note=Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit. {ECO 0000269|PubMed 11884747}; # COFACTOR FDNG_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000269|PubMed 11884747}; Note=Binds 1 [4Fe-4S] cluster per subunit. {ECO 0000269|PubMed 11884747}; # EcoGene EG11227 fdnG # FUNCTION FDNG_ECOLI Formate dehydrogenase allows E.coli to use formate as major electron donor during anaerobic respiration, when nitrate is used as electron acceptor. The alpha subunit FdnG contains the formate oxidation site. Electrons are transferred from formate to menaquinone in the gamma subunit (FdnI), through the 4Fe-4S clusters in the beta subunit (FdnH). Formate dehydrogenase-N is part of a system that generates proton motive force, together with the dissimilatory nitrate reductase (Nar). {ECO 0000269|PubMed 11884747}. # GO_component GO:0009326 formate dehydrogenase complex; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0008430 selenium binding; IDA:EcoCyc. # GO_function GO:0008863 formate dehydrogenase (NAD+) activity; IEA:InterPro. # GO_function GO:0009055 electron carrier activity; IDA:EcoCyc. # GO_function GO:0030151 molybdenum ion binding; IDA:EcoCyc. # GO_function GO:0036397 formate dehydrogenase (quinone) activity; IDA:EcoCyc. # GO_function GO:0043546 molybdopterin cofactor binding; IEA:InterPro. # GO_function GO:0047111 formate dehydrogenase (cytochrome-c-553) activity; IEA:InterPro. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IDA:EcoCyc. # GO_process GO:0009061 anaerobic respiration; IEP:EcoCyc. # GO_process GO:0015944 formate oxidation; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0044281 small molecule metabolic process # INDUCTION By nitrate under anaerobic conditions. {ECO:0000269|PubMed 2168848}. # INTERACTION FDNG_ECOLI P13024 fdhE; NbExp=4; IntAct=EBI-550115, EBI-550129; # IntAct P24183 14 # InterPro IPR006311 TAT_signal # InterPro IPR006443 Formate-DH-alph_fdnG # InterPro IPR006655 Mopterin_OxRdtase_prok_CS # InterPro IPR006656 Mopterin_OxRdtase # InterPro IPR006657 MoPterin_dinucl-bd_dom # InterPro IPR006963 Mopterin_OxRdtase_4Fe-4S_dom # InterPro IPR009010 Asp_de-COase-like_dom # InterPro IPR027467 MopterinOxRdtase_cofactor_BS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00630 Glyoxylate and dicarboxylate metabolism # KEGG_Pathway ko00680 Methane metabolism # KEGG_Pathway ko02020 Two-component system # Organism FDNG_ECOLI Escherichia coli (strain K12) # PATRIC 32118240 VBIEscCol129921_1540 # PDB 1KQF X-ray; 1.60 A; A=1-1015 # PDB 1KQG X-ray; 2.80 A; A=1-1015 # PIR E64900 JS0628 # PROSITE PS00551 MOLYBDOPTERIN_PROK_1 # PROSITE PS00932 MOLYBDOPTERIN_PROK_3 # PROSITE PS51318 TAT # PROSITE PS51669 4FE4S_MOW_BIS_MGD # PTM FDNG_ECOLI Exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven. # Pfam PF00384 Molybdopterin # Pfam PF01568 Molydop_binding # Pfam PF04879 Molybdop_Fe4S4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FDNG_ECOLI Formate dehydrogenase, nitrate-inducible, major subunit # RefSeq NP_415991 NC_000913.3 # SIMILARITY Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. {ECO 0000305}. # SIMILARITY Contains 1 4Fe-4S Mo/W bis-MGD-type domain. {ECO:0000255|PROSITE-ProRule PRU01004}. # SMART SM00926 Molybdop_Fe4S4 # SUBCELLULAR LOCATION FDNG_ECOLI Periplasm {ECO 0000269|PubMed 11884747}. # SUBUNIT Trimer of heterotrimers, consisting of subunits alpha, beta and gamma. {ECO:0000269|PubMed 11884747}. # SUPFAM SSF50692 SSF50692 # TCDB 5.A.3.2 the prokaryotic molybdopterin-containing oxidoreductase (pmo) family # TIGRFAMs TIGR01553 formate-DH-alph # eggNOG COG0243 LUCA # eggNOG ENOG4107QIW Bacteria BLAST swissprot:FDNG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FDNG_ECOLI BioCyc ECOL316407:JW1470-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1470-MONOMER BioCyc EcoCyc:FDNG-MONOMER http://biocyc.org/getid?id=EcoCyc:FDNG-MONOMER BioCyc MetaCyc:FDNG-MONOMER http://biocyc.org/getid?id=MetaCyc:FDNG-MONOMER COG COG0243 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0243 DIP DIP-9573N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9573N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M610507200 http://dx.doi.org/10.1074/jbc.M610507200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1068186 http://dx.doi.org/10.1126/science.1068186 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.5.6 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.5.6 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M75029 http://www.ebi.ac.uk/ena/data/view/M75029 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.1.5.6 http://enzyme.expasy.org/EC/1.1.5.6 EchoBASE EB1209 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1209 EcoGene EG11227 http://www.ecogene.org/geneInfo.php?eg_id=EG11227 EnsemblBacteria AAD13438 http://www.ensemblgenomes.org/id/AAD13438 EnsemblBacteria AAD13438 http://www.ensemblgenomes.org/id/AAD13438 EnsemblBacteria BAA15123 http://www.ensemblgenomes.org/id/BAA15123 EnsemblBacteria BAA15123 http://www.ensemblgenomes.org/id/BAA15123 EnsemblBacteria BAA15123 http://www.ensemblgenomes.org/id/BAA15123 EnsemblBacteria b1474 http://www.ensemblgenomes.org/id/b1474 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009326 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009326 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0008430 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008430 GO_function GO:0008863 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008863 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0030151 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030151 GO_function GO:0036397 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036397 GO_function GO:0043546 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043546 GO_function GO:0047111 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047111 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0009061 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009061 GO_process GO:0015944 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015944 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 946035 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946035 HOGENOM HOG000163271 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000163271&db=HOGENOM6 InParanoid P24183 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P24183 IntAct P24183 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P24183* IntEnz 1.1.5.6 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.5.6 InterPro IPR006311 http://www.ebi.ac.uk/interpro/entry/IPR006311 InterPro IPR006443 http://www.ebi.ac.uk/interpro/entry/IPR006443 InterPro IPR006655 http://www.ebi.ac.uk/interpro/entry/IPR006655 InterPro IPR006656 http://www.ebi.ac.uk/interpro/entry/IPR006656 InterPro IPR006657 http://www.ebi.ac.uk/interpro/entry/IPR006657 InterPro IPR006963 http://www.ebi.ac.uk/interpro/entry/IPR006963 InterPro IPR009010 http://www.ebi.ac.uk/interpro/entry/IPR009010 InterPro IPR027467 http://www.ebi.ac.uk/interpro/entry/IPR027467 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1470 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1470 KEGG_Gene eco:b1474 http://www.genome.jp/dbget-bin/www_bget?eco:b1474 KEGG_Orthology KO:K08348 http://www.genome.jp/dbget-bin/www_bget?KO:K08348 KEGG_Pathway ko00630 http://www.genome.jp/kegg-bin/show_pathway?ko00630 KEGG_Pathway ko00680 http://www.genome.jp/kegg-bin/show_pathway?ko00680 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 KEGG_Reaction rn:R00519 http://www.genome.jp/dbget-bin/www_bget?rn:R00519 MINT MINT-1236143 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1236143 OMA PLHWGFE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PLHWGFE PDB 1KQF http://www.ebi.ac.uk/pdbe-srv/view/entry/1KQF PDB 1KQG http://www.ebi.ac.uk/pdbe-srv/view/entry/1KQG PDBsum 1KQF http://www.ebi.ac.uk/pdbsum/1KQF PDBsum 1KQG http://www.ebi.ac.uk/pdbsum/1KQG PROSITE PS00551 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00551 PROSITE PS00932 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00932 PROSITE PS51318 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51318 PROSITE PS51669 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51669 PSORT swissprot:FDNG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FDNG_ECOLI PSORT-B swissprot:FDNG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FDNG_ECOLI PSORT2 swissprot:FDNG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FDNG_ECOLI Pfam PF00384 http://pfam.xfam.org/family/PF00384 Pfam PF01568 http://pfam.xfam.org/family/PF01568 Pfam PF04879 http://pfam.xfam.org/family/PF04879 Phobius swissprot:FDNG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FDNG_ECOLI PhylomeDB P24183 http://phylomedb.org/?seqid=P24183 ProteinModelPortal P24183 http://www.proteinmodelportal.org/query/uniprot/P24183 PubMed 11884747 http://www.ncbi.nlm.nih.gov/pubmed/11884747 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17218314 http://www.ncbi.nlm.nih.gov/pubmed/17218314 PubMed 1834669 http://www.ncbi.nlm.nih.gov/pubmed/1834669 PubMed 2168848 http://www.ncbi.nlm.nih.gov/pubmed/2168848 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415991 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415991 SMART SM00926 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00926 SMR P24183 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P24183 STRING 511145.b1474 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1474&targetmode=cogs STRING COG0243 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0243&targetmode=cogs SUPFAM SSF50692 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50692 TCDB 5.A.3.2 http://www.tcdb.org/search/result.php?tc=5.A.3.2 TIGRFAMs TIGR01553 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01553 UniProtKB FDNG_ECOLI http://www.uniprot.org/uniprot/FDNG_ECOLI UniProtKB-AC P24183 http://www.uniprot.org/uniprot/P24183 charge swissprot:FDNG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FDNG_ECOLI eggNOG COG0243 http://eggnogapi.embl.de/nog_data/html/tree/COG0243 eggNOG ENOG4107QIW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QIW epestfind swissprot:FDNG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FDNG_ECOLI garnier swissprot:FDNG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FDNG_ECOLI helixturnhelix swissprot:FDNG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FDNG_ECOLI hmoment swissprot:FDNG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FDNG_ECOLI iep swissprot:FDNG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FDNG_ECOLI inforesidue swissprot:FDNG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FDNG_ECOLI octanol swissprot:FDNG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FDNG_ECOLI pepcoil swissprot:FDNG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FDNG_ECOLI pepdigest swissprot:FDNG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FDNG_ECOLI pepinfo swissprot:FDNG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FDNG_ECOLI pepnet swissprot:FDNG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FDNG_ECOLI pepstats swissprot:FDNG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FDNG_ECOLI pepwheel swissprot:FDNG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FDNG_ECOLI pepwindow swissprot:FDNG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FDNG_ECOLI sigcleave swissprot:FDNG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FDNG_ECOLI ## Database ID URL or Descriptions # AltName APPY_ECOLI M5 polypeptide # BioGrid 4263522 5 # EcoGene EG10050 appY # FUNCTION APPY_ECOLI Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions. {ECO 0000269|PubMed 18383615}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0000987 core promoter proximal region sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0016036 cellular response to phosphate starvation; IDA:EcoCyc. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.60 -; 1. # IntAct P05052 26 # InterPro IPR009057 Homeodomain-like # InterPro IPR018060 HTH_AraC # InterPro IPR018062 HTH_AraC-typ_CS # InterPro IPR020449 Tscrpt_reg_HTH_AraC-type # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko03000 Transcription factors # KEGG_Pathway ko02020 Two-component system # MISCELLANEOUS APPY_ECOLI Encoded by the cryptic lambdoid prophage DLP12. # Organism APPY_ECOLI Escherichia coli (strain K12) # PATRIC 32116294 VBIEscCol129921_0587 # PIR A94498 BVECM5 # PRINTS PR00032 HTHARAC # PROSITE PS00041 HTH_ARAC_FAMILY_1 # PROSITE PS01124 HTH_ARAC_FAMILY_2 # Pfam PF12833 HTH_18 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName APPY_ECOLI HTH-type transcriptional regulator AppY # RefSeq NP_415096 NC_000913.3 # RefSeq WP_000386784 NZ_LN832404.1 # SIMILARITY Contains 1 HTH araC/xylS-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00593}. # SMART SM00342 HTH_ARAC # SUPFAM SSF46689 SSF46689 # eggNOG COG2207 LUCA # eggNOG ENOG4108MIW Bacteria BLAST swissprot:APPY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:APPY_ECOLI BioCyc ECOL316407:JW0553-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0553-MONOMER BioCyc EcoCyc:PD00967 http://biocyc.org/getid?id=EcoCyc:PD00967 COG COG2207 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2207 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/15.9.3924 http://dx.doi.org/10.1093/nar/15.9.3924 DOI 10.1111/j.1365-2958.2008.06146.x http://dx.doi.org/10.1111/j.1365-2958.2008.06146.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M24530 http://www.ebi.ac.uk/ena/data/view/M24530 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EMBL Y00138 http://www.ebi.ac.uk/ena/data/view/Y00138 EchoBASE EB0048 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0048 EcoGene EG10050 http://www.ecogene.org/geneInfo.php?eg_id=EG10050 EnsemblBacteria AAC73665 http://www.ensemblgenomes.org/id/AAC73665 EnsemblBacteria AAC73665 http://www.ensemblgenomes.org/id/AAC73665 EnsemblBacteria BAE76339 http://www.ensemblgenomes.org/id/BAE76339 EnsemblBacteria BAE76339 http://www.ensemblgenomes.org/id/BAE76339 EnsemblBacteria BAE76339 http://www.ensemblgenomes.org/id/BAE76339 EnsemblBacteria b0564 http://www.ensemblgenomes.org/id/b0564 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000987 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000987 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0016036 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016036 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 GeneID 948797 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948797 HOGENOM HOG000120708 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120708&db=HOGENOM6 InParanoid P05052 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P05052 IntAct P05052 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P05052* InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR018060 http://www.ebi.ac.uk/interpro/entry/IPR018060 InterPro IPR018062 http://www.ebi.ac.uk/interpro/entry/IPR018062 InterPro IPR020449 http://www.ebi.ac.uk/interpro/entry/IPR020449 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW0553 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0553 KEGG_Gene eco:b0564 http://www.genome.jp/dbget-bin/www_bget?eco:b0564 KEGG_Orthology KO:K07780 http://www.genome.jp/dbget-bin/www_bget?KO:K07780 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 PRINTS PR00032 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00032 PROSITE PS00041 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00041 PROSITE PS01124 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01124 PSORT swissprot:APPY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:APPY_ECOLI PSORT-B swissprot:APPY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:APPY_ECOLI PSORT2 swissprot:APPY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:APPY_ECOLI Pfam PF12833 http://pfam.xfam.org/family/PF12833 Phobius swissprot:APPY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:APPY_ECOLI PhylomeDB P05052 http://phylomedb.org/?seqid=P05052 ProteinModelPortal P05052 http://www.proteinmodelportal.org/query/uniprot/P05052 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18383615 http://www.ncbi.nlm.nih.gov/pubmed/18383615 PubMed 2537825 http://www.ncbi.nlm.nih.gov/pubmed/2537825 PubMed 3295784 http://www.ncbi.nlm.nih.gov/pubmed/3295784 PubMed 8071219 http://www.ncbi.nlm.nih.gov/pubmed/8071219 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415096 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415096 RefSeq WP_000386784 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000386784 SMART SM00342 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00342 SMR P05052 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P05052 STRING 511145.b0564 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0564&targetmode=cogs STRING COG2207 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2207&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 UniProtKB APPY_ECOLI http://www.uniprot.org/uniprot/APPY_ECOLI UniProtKB-AC P05052 http://www.uniprot.org/uniprot/P05052 charge swissprot:APPY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:APPY_ECOLI eggNOG COG2207 http://eggnogapi.embl.de/nog_data/html/tree/COG2207 eggNOG ENOG4108MIW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MIW epestfind swissprot:APPY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:APPY_ECOLI garnier swissprot:APPY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:APPY_ECOLI helixturnhelix swissprot:APPY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:APPY_ECOLI hmoment swissprot:APPY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:APPY_ECOLI iep swissprot:APPY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:APPY_ECOLI inforesidue swissprot:APPY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:APPY_ECOLI octanol swissprot:APPY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:APPY_ECOLI pepcoil swissprot:APPY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:APPY_ECOLI pepdigest swissprot:APPY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:APPY_ECOLI pepinfo swissprot:APPY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:APPY_ECOLI pepnet swissprot:APPY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:APPY_ECOLI pepstats swissprot:APPY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:APPY_ECOLI pepwheel swissprot:APPY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:APPY_ECOLI pepwindow swissprot:APPY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:APPY_ECOLI sigcleave swissprot:APPY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:APPY_ECOLI ## Database ID URL or Descriptions # BioGrid 4261775 6 # EcoGene EG14099 yfbO # Organism YFBO_ECOLI Escherichia coli (strain K12) # PATRIC 32119915 VBIEscCol129921_2367 # PIR H64998 H64998 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFBO_ECOLI Uncharacterized protein YfbO # RefSeq NP_416777 NC_000913.3 # RefSeq WP_000188051 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAE76682.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # eggNOG ENOG4106EES Bacteria # eggNOG ENOG410Y5EM LUCA BLAST swissprot:YFBO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFBO_ECOLI BioCyc ECOL316407:JW2269-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2269-MONOMER BioCyc EcoCyc:G7181-MONOMER http://biocyc.org/getid?id=EcoCyc:G7181-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3852 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3852 EcoGene EG14099 http://www.ecogene.org/geneInfo.php?eg_id=EG14099 EnsemblBacteria AAC75334 http://www.ensemblgenomes.org/id/AAC75334 EnsemblBacteria AAC75334 http://www.ensemblgenomes.org/id/AAC75334 EnsemblBacteria BAE76682 http://www.ensemblgenomes.org/id/BAE76682 EnsemblBacteria BAE76682 http://www.ensemblgenomes.org/id/BAE76682 EnsemblBacteria BAE76682 http://www.ensemblgenomes.org/id/BAE76682 EnsemblBacteria b2274 http://www.ensemblgenomes.org/id/b2274 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946752 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946752 HOGENOM HOG000009755 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009755&db=HOGENOM6 KEGG_Gene ecj:JW2269 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2269 KEGG_Gene eco:b2274 http://www.genome.jp/dbget-bin/www_bget?eco:b2274 PSORT swissprot:YFBO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFBO_ECOLI PSORT-B swissprot:YFBO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFBO_ECOLI PSORT2 swissprot:YFBO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFBO_ECOLI Phobius swissprot:YFBO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFBO_ECOLI ProteinModelPortal P76485 http://www.proteinmodelportal.org/query/uniprot/P76485 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416777 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416777 RefSeq WP_000188051 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000188051 STRING 511145.b2274 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2274&targetmode=cogs UniProtKB YFBO_ECOLI http://www.uniprot.org/uniprot/YFBO_ECOLI UniProtKB-AC P76485 http://www.uniprot.org/uniprot/P76485 charge swissprot:YFBO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFBO_ECOLI eggNOG ENOG4106EES http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106EES eggNOG ENOG410Y5EM http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y5EM epestfind swissprot:YFBO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFBO_ECOLI garnier swissprot:YFBO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFBO_ECOLI helixturnhelix swissprot:YFBO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFBO_ECOLI hmoment swissprot:YFBO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFBO_ECOLI iep swissprot:YFBO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFBO_ECOLI inforesidue swissprot:YFBO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFBO_ECOLI octanol swissprot:YFBO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFBO_ECOLI pepcoil swissprot:YFBO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFBO_ECOLI pepdigest swissprot:YFBO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFBO_ECOLI pepinfo swissprot:YFBO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFBO_ECOLI pepnet swissprot:YFBO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFBO_ECOLI pepstats swissprot:YFBO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFBO_ECOLI pepwheel swissprot:YFBO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFBO_ECOLI pepwindow swissprot:YFBO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFBO_ECOLI sigcleave swissprot:YFBO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFBO_ECOLI ## Database ID URL or Descriptions # BioGrid 4260443 14 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG12003 yehQ # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0043167 ion binding # IntAct P33353 6 # InterPro IPR007527 Znf_SWIM # Organism YEHQ_ECOLI Escherichia coli (strain K12) # PATRIC 48663594 VBIEscCol107702_2143 # PIR A64980 A64980 # PROSITE PS50966 ZF_SWIM; 2 # Pfam PF04434 SWIM; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEHQ_ECOLI Putative uncharacterized protein YehQ # RefSeq WP_001087218 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA60485.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Contains 2 SWIM-type zinc fingers. {ECO:0000255|PROSITE-ProRule PRU00325}. # eggNOG ENOG410903U Bacteria # eggNOG ENOG4111PR2 LUCA BLAST swissprot:YEHQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEHQ_ECOLI BioCyc ECOL316407:JW2110-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2110-MONOMER BioCyc EcoCyc:EG12003-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12003-MONOMER DIP DIP-11905N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11905N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1941 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1941 EcoGene EG12003 http://www.ecogene.org/geneInfo.php?eg_id=EG12003 EnsemblBacteria BAE76598 http://www.ensemblgenomes.org/id/BAE76598 EnsemblBacteria BAE76598 http://www.ensemblgenomes.org/id/BAE76598 EnsemblBacteria BAE76598 http://www.ensemblgenomes.org/id/BAE76598 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 HOGENOM HOG000122200 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122200&db=HOGENOM6 InParanoid P33353 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33353 IntAct P33353 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33353* InterPro IPR007527 http://www.ebi.ac.uk/interpro/entry/IPR007527 KEGG_Gene ecj:JW2110 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2110 MINT MINT-1308029 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1308029 OMA SEEGQTC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SEEGQTC PROSITE PS50966 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50966 PSORT swissprot:YEHQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEHQ_ECOLI PSORT-B swissprot:YEHQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEHQ_ECOLI PSORT2 swissprot:YEHQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEHQ_ECOLI Pfam PF04434 http://pfam.xfam.org/family/PF04434 Phobius swissprot:YEHQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEHQ_ECOLI ProteinModelPortal P33353 http://www.proteinmodelportal.org/query/uniprot/P33353 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001087218 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001087218 STRING 316407.85675235 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85675235&targetmode=cogs UniProtKB YEHQ_ECOLI http://www.uniprot.org/uniprot/YEHQ_ECOLI UniProtKB-AC P33353 http://www.uniprot.org/uniprot/P33353 charge swissprot:YEHQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEHQ_ECOLI eggNOG ENOG410903U http://eggnogapi.embl.de/nog_data/html/tree/ENOG410903U eggNOG ENOG4111PR2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111PR2 epestfind swissprot:YEHQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEHQ_ECOLI garnier swissprot:YEHQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEHQ_ECOLI helixturnhelix swissprot:YEHQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEHQ_ECOLI hmoment swissprot:YEHQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEHQ_ECOLI iep swissprot:YEHQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEHQ_ECOLI inforesidue swissprot:YEHQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEHQ_ECOLI octanol swissprot:YEHQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEHQ_ECOLI pepcoil swissprot:YEHQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEHQ_ECOLI pepdigest swissprot:YEHQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEHQ_ECOLI pepinfo swissprot:YEHQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEHQ_ECOLI pepnet swissprot:YEHQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEHQ_ECOLI pepstats swissprot:YEHQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEHQ_ECOLI pepwheel swissprot:YEHQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEHQ_ECOLI pepwindow swissprot:YEHQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEHQ_ECOLI sigcleave swissprot:YEHQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEHQ_ECOLI ## Database ID URL or Descriptions # EcoGene EG13823 ydfK # INDUCTION YDFK_ECOLI By cold shock, up to 70-fold at 10 degrees Celsius. {ECO 0000269|PubMed 14527658, ECO 0000269|PubMed 21460078}. # IntAct P76154 22 # Organism YDFK_ECOLI Escherichia coli (strain K12) # PATRIC 32118388 VBIEscCol129921_1614 # PIR C64909 C64909 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDFK_ECOLI Uncharacterized protein YdfK # RefSeq NP_416062 NC_000913.3 # RefSeq WP_000836768 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAE76464.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY To E.coli YnaE. {ECO 0000305}. # eggNOG ENOG4105W3V Bacteria # eggNOG ENOG411246H LUCA BLAST swissprot:YDFK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDFK_ECOLI BioCyc ECOL316407:JW1537-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1537-MONOMER BioCyc EcoCyc:G6818-MONOMER http://biocyc.org/getid?id=EcoCyc:G6818-MONOMER DOI 10.1016/S0923-2508(03)00167-0 http://dx.doi.org/10.1016/S0923-2508(03)00167-0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00398-11 http://dx.doi.org/10.1128/JB.00398-11 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3584 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3584 EcoGene EG13823 http://www.ecogene.org/geneInfo.php?eg_id=EG13823 EnsemblBacteria AAC74617 http://www.ensemblgenomes.org/id/AAC74617 EnsemblBacteria AAC74617 http://www.ensemblgenomes.org/id/AAC74617 EnsemblBacteria BAE76464 http://www.ensemblgenomes.org/id/BAE76464 EnsemblBacteria BAE76464 http://www.ensemblgenomes.org/id/BAE76464 EnsemblBacteria BAE76464 http://www.ensemblgenomes.org/id/BAE76464 EnsemblBacteria b1544 http://www.ensemblgenomes.org/id/b1544 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947451 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947451 HOGENOM HOG000127820 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000127820&db=HOGENOM6 IntAct P76154 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76154* KEGG_Gene ecj:JW1537 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1537 KEGG_Gene eco:b1544 http://www.genome.jp/dbget-bin/www_bget?eco:b1544 PSORT swissprot:YDFK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDFK_ECOLI PSORT-B swissprot:YDFK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDFK_ECOLI PSORT2 swissprot:YDFK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDFK_ECOLI Phobius swissprot:YDFK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDFK_ECOLI ProteinModelPortal P76154 http://www.proteinmodelportal.org/query/uniprot/P76154 PubMed 14527658 http://www.ncbi.nlm.nih.gov/pubmed/14527658 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21460078 http://www.ncbi.nlm.nih.gov/pubmed/21460078 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416062 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416062 RefSeq WP_000836768 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000836768 STRING 511145.b1544 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1544&targetmode=cogs UniProtKB YDFK_ECOLI http://www.uniprot.org/uniprot/YDFK_ECOLI UniProtKB-AC P76154 http://www.uniprot.org/uniprot/P76154 charge swissprot:YDFK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDFK_ECOLI eggNOG ENOG4105W3V http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105W3V eggNOG ENOG411246H http://eggnogapi.embl.de/nog_data/html/tree/ENOG411246H epestfind swissprot:YDFK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDFK_ECOLI garnier swissprot:YDFK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDFK_ECOLI helixturnhelix swissprot:YDFK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDFK_ECOLI hmoment swissprot:YDFK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDFK_ECOLI iep swissprot:YDFK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDFK_ECOLI inforesidue swissprot:YDFK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDFK_ECOLI octanol swissprot:YDFK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDFK_ECOLI pepcoil swissprot:YDFK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDFK_ECOLI pepdigest swissprot:YDFK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDFK_ECOLI pepinfo swissprot:YDFK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDFK_ECOLI pepnet swissprot:YDFK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDFK_ECOLI pepstats swissprot:YDFK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDFK_ECOLI pepwheel swissprot:YDFK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDFK_ECOLI pepwindow swissprot:YDFK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDFK_ECOLI sigcleave swissprot:YDFK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDFK_ECOLI ## Database ID URL or Descriptions # AltName SIXA_ECOLI RX6 # BioGrid 4260532 16 # CDD cd07067 HP_PGM_like # EcoGene EG14126 sixA # FUNCTION SIXA_ECOLI Exhibits phosphohistidine phosphatase activity towards the HPt domain of the ArcB sensor involved in the multistep His- Asp phosphorelay. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0004721 phosphoprotein phosphatase activity; IEA:UniProtKB-KW. # GO_function GO:0008969 phosphohistidine phosphatase activity; IDA:EcoliWiki. # GO_process GO:0006464 cellular protein modification process; IMP:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016791 phosphatase activity # GOslim_process GO:0006464 cellular protein modification process # Gene3D 3.40.50.1240 -; 1. # INTERACTION SIXA_ECOLI Q2EES9 torI; NbExp=3; IntAct=EBI-548621, EBI-9154838; # IntAct P76502 9 # InterPro IPR004449 SixA # InterPro IPR013078 His_Pase_superF_clade-1 # InterPro IPR029033 His_PPase_superfam # KEGG_Brite ko01000 Enzymes # Organism SIXA_ECOLI Escherichia coli (strain K12) # PATRIC 32120053 VBIEscCol129921_2436 # PDB 1UJB X-ray; 2.06 A; A=1-161 # PDB 1UJC X-ray; 1.90 A; A=1-161 # PIR B65007 B65007 # Pfam PF00300 His_Phos_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SIXA_ECOLI Phosphohistidine phosphatase SixA # RefSeq NP_416842 NC_000913.3 # RefSeq WP_001195819 NZ_LN832404.1 # SIMILARITY Belongs to the SixA phosphatase family. {ECO 0000305}. # SUPFAM SSF53254 SSF53254 # TIGRFAMs TIGR00249 sixA # eggNOG COG2062 LUCA # eggNOG ENOG4108BY2 Bacteria BLAST swissprot:SIXA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SIXA_ECOLI BioCyc ECOL316407:JW2337-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2337-MONOMER BioCyc EcoCyc:G7211-MONOMER http://biocyc.org/getid?id=EcoCyc:G7211-MONOMER COG COG2062 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2062 DIP DIP-10885N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10885N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1998.00703.x http://dx.doi.org/10.1046/j.1365-2958.1998.00703.x DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.3.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D86298 http://www.ebi.ac.uk/ena/data/view/D86298 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.3.- http://enzyme.expasy.org/EC/3.1.3.- EchoBASE EB3878 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3878 EcoGene EG14126 http://www.ecogene.org/geneInfo.php?eg_id=EG14126 EnsemblBacteria AAC75400 http://www.ensemblgenomes.org/id/AAC75400 EnsemblBacteria AAC75400 http://www.ensemblgenomes.org/id/AAC75400 EnsemblBacteria BAA16194 http://www.ensemblgenomes.org/id/BAA16194 EnsemblBacteria BAA16194 http://www.ensemblgenomes.org/id/BAA16194 EnsemblBacteria BAA16194 http://www.ensemblgenomes.org/id/BAA16194 EnsemblBacteria b2340 http://www.ensemblgenomes.org/id/b2340 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004721 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004721 GO_function GO:0008969 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008969 GO_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 Gene3D 3.40.50.1240 http://www.cathdb.info/version/latest/superfamily/3.40.50.1240 GeneID 946815 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946815 HOGENOM HOG000238872 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000238872&db=HOGENOM6 InParanoid P76502 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76502 IntAct P76502 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76502* IntEnz 3.1.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3 InterPro IPR004449 http://www.ebi.ac.uk/interpro/entry/IPR004449 InterPro IPR013078 http://www.ebi.ac.uk/interpro/entry/IPR013078 InterPro IPR029033 http://www.ebi.ac.uk/interpro/entry/IPR029033 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2337 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2337 KEGG_Gene eco:b2340 http://www.genome.jp/dbget-bin/www_bget?eco:b2340 KEGG_Orthology KO:K08296 http://www.genome.jp/dbget-bin/www_bget?KO:K08296 OMA MQVLIMR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MQVLIMR PDB 1UJB http://www.ebi.ac.uk/pdbe-srv/view/entry/1UJB PDB 1UJC http://www.ebi.ac.uk/pdbe-srv/view/entry/1UJC PDBsum 1UJB http://www.ebi.ac.uk/pdbsum/1UJB PDBsum 1UJC http://www.ebi.ac.uk/pdbsum/1UJC PSORT swissprot:SIXA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SIXA_ECOLI PSORT-B swissprot:SIXA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SIXA_ECOLI PSORT2 swissprot:SIXA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SIXA_ECOLI Pfam PF00300 http://pfam.xfam.org/family/PF00300 Phobius swissprot:SIXA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SIXA_ECOLI PhylomeDB P76502 http://phylomedb.org/?seqid=P76502 ProteinModelPortal P76502 http://www.proteinmodelportal.org/query/uniprot/P76502 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9489669 http://www.ncbi.nlm.nih.gov/pubmed/9489669 RefSeq NP_416842 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416842 RefSeq WP_001195819 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001195819 SMR P76502 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76502 STRING 511145.b2340 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2340&targetmode=cogs STRING COG2062 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2062&targetmode=cogs SUPFAM SSF53254 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53254 TIGRFAMs TIGR00249 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00249 UniProtKB SIXA_ECOLI http://www.uniprot.org/uniprot/SIXA_ECOLI UniProtKB-AC P76502 http://www.uniprot.org/uniprot/P76502 charge swissprot:SIXA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SIXA_ECOLI eggNOG COG2062 http://eggnogapi.embl.de/nog_data/html/tree/COG2062 eggNOG ENOG4108BY2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108BY2 epestfind swissprot:SIXA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SIXA_ECOLI garnier swissprot:SIXA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SIXA_ECOLI helixturnhelix swissprot:SIXA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SIXA_ECOLI hmoment swissprot:SIXA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SIXA_ECOLI iep swissprot:SIXA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SIXA_ECOLI inforesidue swissprot:SIXA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SIXA_ECOLI octanol swissprot:SIXA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SIXA_ECOLI pepcoil swissprot:SIXA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SIXA_ECOLI pepdigest swissprot:SIXA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SIXA_ECOLI pepinfo swissprot:SIXA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SIXA_ECOLI pepnet swissprot:SIXA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SIXA_ECOLI pepstats swissprot:SIXA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SIXA_ECOLI pepwheel swissprot:SIXA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SIXA_ECOLI pepwindow swissprot:SIXA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SIXA_ECOLI sigcleave swissprot:SIXA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SIXA_ECOLI ## Database ID URL or Descriptions # AltName LPHI_ECOLI His operon attenuator peptide # EcoGene EG11269 hisL # FUNCTION LPHI_ECOLI This protein is involved in the attenuation mechanism for the control of the expression of the his operon structural genes. # GO_process GO:0000105 histidine biosynthetic process; IEA:UniProtKB-KW. # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # InterPro IPR012565 His_leader # Organism LPHI_ECOLI Escherichia coli (strain K12) # PIR A03594 LFECH # Pfam PF08047 His_leader # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LPHI_ECOLI His operon leader peptide # RefSeq NP_416522 NC_000913.3 # SIMILARITY Belongs to the HisL family. {ECO 0000305}. BLAST swissprot:LPHI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LPHI_ECOLI BioCyc ECOL316407:JW2000-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2000-MONOMER BioCyc EcoCyc:EG11269-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11269-MONOMER DOI 10.1016/0022-2836(88)90194-5 http://dx.doi.org/10.1016/0022-2836(88)90194-5 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.75.9.4276 http://dx.doi.org/10.1073/pnas.75.9.4276 DOI 10.1093/nar/9.9.2075 http://dx.doi.org/10.1093/nar/9.9.2075 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00284 http://www.ebi.ac.uk/ena/data/view/V00284 EMBL V00285 http://www.ebi.ac.uk/ena/data/view/V00285 EMBL X13462 http://www.ebi.ac.uk/ena/data/view/X13462 EchoBASE EB1248 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1248 EcoGene EG11269 http://www.ecogene.org/geneInfo.php?eg_id=EG11269 EnsemblBacteria AAC75079 http://www.ensemblgenomes.org/id/AAC75079 EnsemblBacteria AAC75079 http://www.ensemblgenomes.org/id/AAC75079 EnsemblBacteria BAE76570 http://www.ensemblgenomes.org/id/BAE76570 EnsemblBacteria BAE76570 http://www.ensemblgenomes.org/id/BAE76570 EnsemblBacteria BAE76570 http://www.ensemblgenomes.org/id/BAE76570 EnsemblBacteria b2018 http://www.ensemblgenomes.org/id/b2018 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0000105 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000105 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 946547 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946547 InterPro IPR012565 http://www.ebi.ac.uk/interpro/entry/IPR012565 KEGG_Gene ecj:JW2000 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2000 KEGG_Gene eco:b2018 http://www.genome.jp/dbget-bin/www_bget?eco:b2018 PSORT swissprot:LPHI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LPHI_ECOLI PSORT-B swissprot:LPHI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LPHI_ECOLI PSORT2 swissprot:LPHI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LPHI_ECOLI Pfam PF08047 http://pfam.xfam.org/family/PF08047 Phobius swissprot:LPHI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LPHI_ECOLI PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3062174 http://www.ncbi.nlm.nih.gov/pubmed/3062174 PubMed 360215 http://www.ncbi.nlm.nih.gov/pubmed/360215 PubMed 6170941 http://www.ncbi.nlm.nih.gov/pubmed/6170941 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416522 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416522 STRING 511145.b2018 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2018&targetmode=cogs UniProtKB LPHI_ECOLI http://www.uniprot.org/uniprot/LPHI_ECOLI UniProtKB-AC P60995 http://www.uniprot.org/uniprot/P60995 charge swissprot:LPHI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LPHI_ECOLI epestfind swissprot:LPHI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LPHI_ECOLI garnier swissprot:LPHI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LPHI_ECOLI helixturnhelix swissprot:LPHI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LPHI_ECOLI hmoment swissprot:LPHI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LPHI_ECOLI iep swissprot:LPHI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LPHI_ECOLI inforesidue swissprot:LPHI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LPHI_ECOLI octanol swissprot:LPHI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LPHI_ECOLI pepcoil swissprot:LPHI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LPHI_ECOLI pepdigest swissprot:LPHI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LPHI_ECOLI pepinfo swissprot:LPHI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LPHI_ECOLI pepnet swissprot:LPHI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LPHI_ECOLI pepstats swissprot:LPHI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LPHI_ECOLI pepwheel swissprot:LPHI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LPHI_ECOLI pepwindow swissprot:LPHI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LPHI_ECOLI sigcleave swissprot:LPHI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LPHI_ECOLI ## Database ID URL or Descriptions # AltName GPPA_ECOLI Guanosine pentaphosphate phosphohydrolase # AltName GPPA_ECOLI pppGpp-5'-phosphohydrolase # BioGrid 4263319 6 # CATALYTIC ACTIVITY GPPA_ECOLI Guanosine 5'-triphosphate,3'-diphosphate + H(2)O = guanosine 3',5'-bis(diphosphate) + phosphate. # EcoGene EG10413 gpp # FUNCTION GPPA_ECOLI Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities. # GO_function GO:0008894 guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity; IDA:EcoCyc. # GO_process GO:0006793 phosphorus metabolic process; IMP:EcoCyc. # GO_process GO:0015949 nucleobase-containing small molecule interconversion; IMP:EcoCyc. # GO_process GO:0015970 guanosine tetraphosphate biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0015974 guanosine pentaphosphate catabolic process; IEA:InterPro. # GO_process GO:0042594 response to starvation; IMP:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # GOslim_process GO:0044281 small molecule metabolic process # HAMAP MF_01550 GppA # InterPro IPR003695 Ppx_GppA # InterPro IPR023709 Guo-5TP_3DP_PyrP # InterPro IPR030673 PyroPPase_GppA_Ppx # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # Organism GPPA_ECOLI Escherichia coli (strain K12) # PATHWAY Purine metabolism; ppGpp biosynthesis; ppGpp from GTP step 1/2. # PATRIC 32123049 VBIEscCol129921_3894 # PIR A48285 A48285 # PIRSF PIRSF001267 Pyrophosphatase_GppA_Ppx # Pfam PF02541 Ppx-GppA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GPPA_ECOLI Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase # RefSeq WP_001295254 NZ_LN832404.1 # RefSeq YP_026252 NC_000913.3 # SIMILARITY Belongs to the GppA/Ppx family. GppA subfamily. {ECO 0000305}. # UniPathway UPA00908 UER00884 # eggNOG COG0248 LUCA # eggNOG ENOG4105C9X Bacteria BLAST swissprot:GPPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GPPA_ECOLI BioCyc ECOL316407:JW5603-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5603-MONOMER BioCyc EcoCyc:PPPGPPHYDRO-MONOMER http://biocyc.org/getid?id=EcoCyc:PPPGPPHYDRO-MONOMER BioCyc MetaCyc:PPPGPPHYDRO-MONOMER http://biocyc.org/getid?id=MetaCyc:PPPGPPHYDRO-MONOMER COG COG0248 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0248 DOI 10.1016/0968-0004(93)90172-J http://dx.doi.org/10.1016/0968-0004(93)90172-J DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.90.15.7029 http://dx.doi.org/10.1073/pnas.90.15.7029 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.1.40 http://www.genome.jp/dbget-bin/www_bget?EC:3.6.1.40 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M83316 http://www.ebi.ac.uk/ena/data/view/M83316 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.6.1.40 http://enzyme.expasy.org/EC/3.6.1.40 EchoBASE EB0408 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0408 EcoGene EG10413 http://www.ecogene.org/geneInfo.php?eg_id=EG10413 EnsemblBacteria AAT48210 http://www.ensemblgenomes.org/id/AAT48210 EnsemblBacteria AAT48210 http://www.ensemblgenomes.org/id/AAT48210 EnsemblBacteria BAE77519 http://www.ensemblgenomes.org/id/BAE77519 EnsemblBacteria BAE77519 http://www.ensemblgenomes.org/id/BAE77519 EnsemblBacteria BAE77519 http://www.ensemblgenomes.org/id/BAE77519 EnsemblBacteria b3779 http://www.ensemblgenomes.org/id/b3779 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008894 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008894 GO_process GO:0006793 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006793 GO_process GO:0015949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015949 GO_process GO:0015970 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015970 GO_process GO:0015974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015974 GO_process GO:0042594 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042594 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 948291 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948291 HAMAP MF_01550 http://hamap.expasy.org/unirule/MF_01550 HOGENOM HOG000258672 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000258672&db=HOGENOM6 InParanoid P25552 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P25552 IntEnz 3.6.1.40 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.1.40 InterPro IPR003695 http://www.ebi.ac.uk/interpro/entry/IPR003695 InterPro IPR023709 http://www.ebi.ac.uk/interpro/entry/IPR023709 InterPro IPR030673 http://www.ebi.ac.uk/interpro/entry/IPR030673 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5603 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5603 KEGG_Gene eco:b3779 http://www.genome.jp/dbget-bin/www_bget?eco:b3779 KEGG_Orthology KO:K01524 http://www.genome.jp/dbget-bin/www_bget?KO:K01524 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Reaction rn:R03409 http://www.genome.jp/dbget-bin/www_bget?rn:R03409 OMA QGWQICV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QGWQICV PSORT swissprot:GPPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GPPA_ECOLI PSORT-B swissprot:GPPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GPPA_ECOLI PSORT2 swissprot:GPPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GPPA_ECOLI Pfam PF02541 http://pfam.xfam.org/family/PF02541 Phobius swissprot:GPPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GPPA_ECOLI PhylomeDB P25552 http://phylomedb.org/?seqid=P25552 ProteinModelPortal P25552 http://www.proteinmodelportal.org/query/uniprot/P25552 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1931833 http://www.ncbi.nlm.nih.gov/pubmed/1931833 PubMed 8212131 http://www.ncbi.nlm.nih.gov/pubmed/8212131 PubMed 8394006 http://www.ncbi.nlm.nih.gov/pubmed/8394006 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001295254 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295254 RefSeq YP_026252 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026252 SMR P25552 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P25552 STRING 511145.b3779 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3779&targetmode=cogs STRING COG0248 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0248&targetmode=cogs UniProtKB GPPA_ECOLI http://www.uniprot.org/uniprot/GPPA_ECOLI UniProtKB-AC P25552 http://www.uniprot.org/uniprot/P25552 charge swissprot:GPPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GPPA_ECOLI eggNOG COG0248 http://eggnogapi.embl.de/nog_data/html/tree/COG0248 eggNOG ENOG4105C9X http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C9X epestfind swissprot:GPPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GPPA_ECOLI garnier swissprot:GPPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GPPA_ECOLI helixturnhelix swissprot:GPPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GPPA_ECOLI hmoment swissprot:GPPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GPPA_ECOLI iep swissprot:GPPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GPPA_ECOLI inforesidue swissprot:GPPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GPPA_ECOLI octanol swissprot:GPPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GPPA_ECOLI pepcoil swissprot:GPPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GPPA_ECOLI pepdigest swissprot:GPPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GPPA_ECOLI pepinfo swissprot:GPPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GPPA_ECOLI pepnet swissprot:GPPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GPPA_ECOLI pepstats swissprot:GPPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GPPA_ECOLI pepwheel swissprot:GPPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GPPA_ECOLI pepwindow swissprot:GPPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GPPA_ECOLI sigcleave swissprot:GPPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GPPA_ECOLI ## Database ID URL or Descriptions # BioGrid 4263324 13 # DISRUPTION PHENOTYPE Mutants lack FDH-N activity and exhibit defects in FDH-H activity. {ECO:0000269|PubMed 3077634}. # EcoGene EG11859 fdhD # FUNCTION FDHD_ECOLI Required for formate dehydrogenase (FDH) activity (PubMed 3077634, PubMed 8522521, PubMed 22194618, PubMed 25649206). Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Specifically interacts with IscS and stimulates its cysteine desulfurase activity. Also binds the molybdenum cofactor (PubMed 22194618, PubMed 25649206). Required for activity of formate dehydrogenase N (FDH-N), formate dehydrogenase O (FDH-O) and formate dehydrogenase H (FDH-H) (PubMed 3077634, PubMed 8522521, PubMed 22194618). {ECO 0000269|PubMed 22194618, ECO 0000269|PubMed 25649206, ECO 0000269|PubMed 3077634, ECO 0000269|PubMed 8522521}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0016783 sulfurtransferase activity; IEA:InterPro. # GO_function GO:0043546 molybdopterin cofactor binding; IDA:EcoCyc. # GO_function GO:0097163 sulfur carrier activity; IMP:EcoCyc. # GO_process GO:0006777 Mo-molybdopterin cofactor biosynthetic process; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0051186 cofactor metabolic process # HAMAP MF_00187 FdhD # INDUCTION Repressed by aerobiosis. {ECO:0000269|PubMed 2170340}. # IntAct P32177 19 # InterPro IPR003786 FdhD # InterPro IPR016193 Cytidine_deaminase-like # Organism FDHD_ECOLI Escherichia coli (strain K12) # PATRIC 32123299 VBIEscCol129921_4010 # PDB 4PDE X-ray; 2.80 A; A=1-277 # PIR S40839 S40839 # PIRSF PIRSF015626 FdhD # Pfam PF02634 FdhD-NarQ # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Sulfurtransferase FdhD {ECO:0000255|HAMAP-Rule MF_00187, ECO:0000305} # RefSeq NP_418331 NC_000913.3 # RefSeq WP_000753617 NZ_LN832404.1 # SIMILARITY Belongs to the FdhD family. {ECO:0000255|HAMAP- Rule MF_00187, ECO:0000305}. # SUBCELLULAR LOCATION FDHD_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00187, ECO 0000269|PubMed 2170340}. # SUBUNIT FDHD_ECOLI Homodimer (PubMed 25649206). Interacts with IscS (PubMed 22194618). {ECO 0000269|PubMed 22194618, ECO 0000269|PubMed 25649206}. # SUPFAM SSF53927 SSF53927 # TIGRFAMs TIGR00129 fdhD_narQ # eggNOG COG1526 LUCA # eggNOG ENOG4107H9G Bacteria BLAST swissprot:FDHD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FDHD_ECOLI BioCyc ECOL316407:JW3866-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3866-MONOMER BioCyc EcoCyc:EG11859-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11859-MONOMER COG COG1526 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1526 DIP DIP-9570N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9570N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/ncomms7148 http://dx.doi.org/10.1038/ncomms7148 DOI 10.1074/jbc.M111.327122 http://dx.doi.org/10.1074/jbc.M111.327122 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1099/00221287-134-12-3129 http://dx.doi.org/10.1099/00221287-134-12-3129 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1805 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1805 EcoGene EG11859 http://www.ecogene.org/geneInfo.php?eg_id=EG11859 EnsemblBacteria AAC76877 http://www.ensemblgenomes.org/id/AAC76877 EnsemblBacteria AAC76877 http://www.ensemblgenomes.org/id/AAC76877 EnsemblBacteria BAE77414 http://www.ensemblgenomes.org/id/BAE77414 EnsemblBacteria BAE77414 http://www.ensemblgenomes.org/id/BAE77414 EnsemblBacteria BAE77414 http://www.ensemblgenomes.org/id/BAE77414 EnsemblBacteria b3895 http://www.ensemblgenomes.org/id/b3895 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0016783 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016783 GO_function GO:0043546 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043546 GO_function GO:0097163 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097163 GO_process GO:0006777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006777 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GeneID 948393 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948393 HAMAP MF_00187 http://hamap.expasy.org/unirule/MF_00187 HOGENOM HOG000079468 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000079468&db=HOGENOM6 InParanoid P32177 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32177 IntAct P32177 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32177* InterPro IPR003786 http://www.ebi.ac.uk/interpro/entry/IPR003786 InterPro IPR016193 http://www.ebi.ac.uk/interpro/entry/IPR016193 KEGG_Gene ecj:JW3866 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3866 KEGG_Gene eco:b3895 http://www.genome.jp/dbget-bin/www_bget?eco:b3895 KEGG_Orthology KO:K02379 http://www.genome.jp/dbget-bin/www_bget?KO:K02379 MINT MINT-1228712 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1228712 OMA PFTQTFS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PFTQTFS PDB 4PDE http://www.ebi.ac.uk/pdbe-srv/view/entry/4PDE PDBsum 4PDE http://www.ebi.ac.uk/pdbsum/4PDE PSORT swissprot:FDHD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FDHD_ECOLI PSORT-B swissprot:FDHD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FDHD_ECOLI PSORT2 swissprot:FDHD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FDHD_ECOLI Pfam PF02634 http://pfam.xfam.org/family/PF02634 Phobius swissprot:FDHD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FDHD_ECOLI PhylomeDB P32177 http://phylomedb.org/?seqid=P32177 ProteinModelPortal P32177 http://www.proteinmodelportal.org/query/uniprot/P32177 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2170340 http://www.ncbi.nlm.nih.gov/pubmed/2170340 PubMed 22194618 http://www.ncbi.nlm.nih.gov/pubmed/22194618 PubMed 25649206 http://www.ncbi.nlm.nih.gov/pubmed/25649206 PubMed 3077634 http://www.ncbi.nlm.nih.gov/pubmed/3077634 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 8522521 http://www.ncbi.nlm.nih.gov/pubmed/8522521 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418331 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418331 RefSeq WP_000753617 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000753617 SMR P32177 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32177 STRING 511145.b3895 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3895&targetmode=cogs STRING COG1526 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1526&targetmode=cogs SUPFAM SSF53927 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53927 TIGRFAMs TIGR00129 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00129 UniProtKB FDHD_ECOLI http://www.uniprot.org/uniprot/FDHD_ECOLI UniProtKB-AC P32177 http://www.uniprot.org/uniprot/P32177 charge swissprot:FDHD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FDHD_ECOLI eggNOG COG1526 http://eggnogapi.embl.de/nog_data/html/tree/COG1526 eggNOG ENOG4107H9G http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107H9G epestfind swissprot:FDHD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FDHD_ECOLI garnier swissprot:FDHD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FDHD_ECOLI helixturnhelix swissprot:FDHD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FDHD_ECOLI hmoment swissprot:FDHD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FDHD_ECOLI iep swissprot:FDHD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FDHD_ECOLI inforesidue swissprot:FDHD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FDHD_ECOLI octanol swissprot:FDHD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FDHD_ECOLI pepcoil swissprot:FDHD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FDHD_ECOLI pepdigest swissprot:FDHD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FDHD_ECOLI pepinfo swissprot:FDHD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FDHD_ECOLI pepnet swissprot:FDHD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FDHD_ECOLI pepstats swissprot:FDHD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FDHD_ECOLI pepwheel swissprot:FDHD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FDHD_ECOLI pepwindow swissprot:FDHD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FDHD_ECOLI sigcleave swissprot:FDHD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FDHD_ECOLI ## Database ID URL or Descriptions # BioGrid 4261940 252 # CDD cd10225 MreB_like # ENZYME REGULATION MREB_ECOLI Polymerization is inhibited by toxins CbtA and CptA, as well as by A22 ([S-(3,4-dichlorobenzyl)isothiourea)] all of which cause cell rounding and eventual death. Inhibition by toxin CbtA is neutralized by cytoskeleton bundling-enhancing protein CbeA, inhibition by toxin CptA is neutralized by antitoxin CptB, while inhibition by A22 can be neutralized by overexpression of CbeA. {ECO 0000269|PubMed 21166897, ECO 0000269|PubMed 22239607, ECO 0000269|PubMed 22515815}. # EcoGene EG10608 mreB # FUNCTION MREB_ECOLI Involved in formation of the rod shape of the cell. May act as a negative regulator of FtsI. Polymerization and bundle formation is enhanced by CbeA. {ECO 0000269|PubMed 2687239}. # GO_component GO:0005856 cytoskeleton; IDA:EcoCyc. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0031226 intrinsic component of plasma membrane; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0000902 cell morphogenesis; IEA:InterPro. # GO_process GO:0008360 regulation of cell shape; IMP:EcoCyc. # GO_process GO:0043093 FtsZ-dependent cytokinesis; IDA:EcoCyc. # GO_process GO:0051782 negative regulation of cell division; IMP:CACAO. # GO_process GO:0051983 regulation of chromosome segregation; IMP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005856 cytoskeleton # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0000902 cell morphogenesis # GOslim_process GO:0008150 biological_process # INTERACTION MREB_ECOLI Self; NbExp=2; IntAct=EBI-371008, EBI-371008; P76364 cbeA; NbExp=2; IntAct=EBI-371008, EBI-1126877; P0A9A6 ftsZ; NbExp=6; IntAct=EBI-371008, EBI-370963; # IntAct P0A9X4 79 # InterPro IPR004753 MreB # KEGG_Brite ko03036 Chromosome # KEGG_Brite ko04812 Cytoskeleton proteins # Organism MREB_ECOLI Escherichia coli (strain K12) # PATRIC 32121928 VBIEscCol129921_3348 # PRINTS PR01652 SHAPEPROTEIN # Pfam PF06723 MreB_Mbl # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MREB_ECOLI Rod shape-determining protein MreB # RefSeq NP_417717 NC_000913.3 # RefSeq WP_000913396 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA58054.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the FtsA/MreB family. {ECO 0000305}. # SUBUNIT MREB_ECOLI Interacts with FtsZ, toxins CbtA and CptA, and cytoskeleton bundling-enhancing protein CbeA. {ECO 0000269|PubMed 21166897, ECO 0000269|PubMed 22239607, ECO 0000269|PubMed 22515815}. # TCDB 9.B.157.1 the cell shape-determining mrebcd (mrebcd) family # TIGRFAMs TIGR00904 mreB # eggNOG COG1077 LUCA BLAST swissprot:MREB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MREB_ECOLI BioCyc ECOL316407:JW3220-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3220-MONOMER BioCyc EcoCyc:EG10608-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10608-MONOMER COG COG1077 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1077 DIP DIP-31874N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31874N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2010.07433.x http://dx.doi.org/10.1111/j.1365-2958.2010.07433.x DOI 10.1111/j.1365-2958.2012.08068.x http://dx.doi.org/10.1111/j.1365-2958.2012.08068.x DOI 10.1111/j.1574-6968.2012.02496.x http://dx.doi.org/10.1111/j.1574-6968.2012.02496.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M22055 http://www.ebi.ac.uk/ena/data/view/M22055 EMBL M31792 http://www.ebi.ac.uk/ena/data/view/M31792 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB0603 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0603 EcoGene EG10608 http://www.ecogene.org/geneInfo.php?eg_id=EG10608 EnsemblBacteria AAC76283 http://www.ensemblgenomes.org/id/AAC76283 EnsemblBacteria AAC76283 http://www.ensemblgenomes.org/id/AAC76283 EnsemblBacteria BAE77293 http://www.ensemblgenomes.org/id/BAE77293 EnsemblBacteria BAE77293 http://www.ensemblgenomes.org/id/BAE77293 EnsemblBacteria BAE77293 http://www.ensemblgenomes.org/id/BAE77293 EnsemblBacteria b3251 http://www.ensemblgenomes.org/id/b3251 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005856 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005856 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0031226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031226 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0000902 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000902 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0043093 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043093 GO_process GO:0051782 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051782 GO_process GO:0051983 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051983 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005856 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005856 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0000902 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000902 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 24909945 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24909945 GeneID 948588 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948588 HOGENOM HOG000019757 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000019757&db=HOGENOM6 InParanoid P0A9X4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9X4 IntAct P0A9X4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9X4* InterPro IPR004753 http://www.ebi.ac.uk/interpro/entry/IPR004753 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Brite ko04812 http://www.genome.jp/dbget-bin/www_bget?ko04812 KEGG_Gene ecj:JW3220 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3220 KEGG_Gene eco:b3251 http://www.genome.jp/dbget-bin/www_bget?eco:b3251 KEGG_Orthology KO:K03569 http://www.genome.jp/dbget-bin/www_bget?KO:K03569 MINT MINT-1222190 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1222190 OMA YIAEDPL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YIAEDPL PRINTS PR01652 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01652 PSORT swissprot:MREB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MREB_ECOLI PSORT-B swissprot:MREB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MREB_ECOLI PSORT2 swissprot:MREB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MREB_ECOLI Pfam PF06723 http://pfam.xfam.org/family/PF06723 Phobius swissprot:MREB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MREB_ECOLI PhylomeDB P0A9X4 http://phylomedb.org/?seqid=P0A9X4 ProteinModelPortal P0A9X4 http://www.proteinmodelportal.org/query/uniprot/P0A9X4 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21166897 http://www.ncbi.nlm.nih.gov/pubmed/21166897 PubMed 22239607 http://www.ncbi.nlm.nih.gov/pubmed/22239607 PubMed 22515815 http://www.ncbi.nlm.nih.gov/pubmed/22515815 PubMed 2687239 http://www.ncbi.nlm.nih.gov/pubmed/2687239 PubMed 3049542 http://www.ncbi.nlm.nih.gov/pubmed/3049542 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_417717 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417717 RefSeq WP_000913396 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000913396 SMR P0A9X4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9X4 STRING 511145.b3251 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3251&targetmode=cogs STRING COG1077 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1077&targetmode=cogs TCDB 9.B.157.1 http://www.tcdb.org/search/result.php?tc=9.B.157.1 TIGRFAMs TIGR00904 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00904 UniProtKB MREB_ECOLI http://www.uniprot.org/uniprot/MREB_ECOLI UniProtKB-AC P0A9X4 http://www.uniprot.org/uniprot/P0A9X4 charge swissprot:MREB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MREB_ECOLI eggNOG COG1077 http://eggnogapi.embl.de/nog_data/html/tree/COG1077 epestfind swissprot:MREB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MREB_ECOLI garnier swissprot:MREB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MREB_ECOLI helixturnhelix swissprot:MREB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MREB_ECOLI hmoment swissprot:MREB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MREB_ECOLI iep swissprot:MREB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MREB_ECOLI inforesidue swissprot:MREB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MREB_ECOLI octanol swissprot:MREB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MREB_ECOLI pepcoil swissprot:MREB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MREB_ECOLI pepdigest swissprot:MREB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MREB_ECOLI pepinfo swissprot:MREB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MREB_ECOLI pepnet swissprot:MREB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MREB_ECOLI pepstats swissprot:MREB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MREB_ECOLI pepwheel swissprot:MREB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MREB_ECOLI pepwindow swissprot:MREB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MREB_ECOLI sigcleave swissprot:MREB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MREB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260212 7 # EcoGene EG13797 ydeO # FUNCTION YDEO_ECOLI Induces the expression of gadE and mdtEF. Could also regulate the expression of other genes involved in acid resistance. {ECO 0000269|PubMed 12694615}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0000987 core promoter proximal region sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.60 -; 1. # INDUCTION Induced by EvgA. {ECO:0000269|PubMed 12399493}. # InterPro IPR009057 Homeodomain-like # InterPro IPR018060 HTH_AraC # InterPro IPR018062 HTH_AraC-typ_CS # InterPro IPR020449 Tscrpt_reg_HTH_AraC-type # Organism YDEO_ECOLI Escherichia coli (strain K12) # PATRIC 32118292 VBIEscCol129921_1566 # PIR F64903 F64903 # PRINTS PR00032 HTHARAC # PROSITE PS00041 HTH_ARAC_FAMILY_1 # PROSITE PS01124 HTH_ARAC_FAMILY_2 # Pfam PF12833 HTH_18 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDEO_ECOLI HTH-type transcriptional regulator YdeO # RefSeq NP_416016 NC_000913.3 # RefSeq WP_000060495 NZ_LN832404.1 # SIMILARITY Contains 1 HTH araC/xylS-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00593}. # SMART SM00342 HTH_ARAC # SUPFAM SSF46689 SSF46689 # eggNOG COG2207 LUCA # eggNOG ENOG4105Z68 Bacteria BLAST swissprot:YDEO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDEO_ECOLI BioCyc ECOL316407:JW1494-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1494-MONOMER BioCyc EcoCyc:G6789-MONOMER http://biocyc.org/getid?id=EcoCyc:G6789-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2003.03477.x http://dx.doi.org/10.1046/j.1365-2958.2003.03477.x DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.22.6225-6234.2002 http://dx.doi.org/10.1128/JB.184.22.6225-6234.2002 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3558 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3558 EcoGene EG13797 http://www.ecogene.org/geneInfo.php?eg_id=EG13797 EnsemblBacteria AAC74572 http://www.ensemblgenomes.org/id/AAC74572 EnsemblBacteria AAC74572 http://www.ensemblgenomes.org/id/AAC74572 EnsemblBacteria BAA15173 http://www.ensemblgenomes.org/id/BAA15173 EnsemblBacteria BAA15173 http://www.ensemblgenomes.org/id/BAA15173 EnsemblBacteria BAA15173 http://www.ensemblgenomes.org/id/BAA15173 EnsemblBacteria b1499 http://www.ensemblgenomes.org/id/b1499 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000987 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000987 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 GeneID 945922 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945922 HOGENOM HOG000120708 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120708&db=HOGENOM6 InParanoid P76135 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76135 IntAct P76135 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76135* InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR018060 http://www.ebi.ac.uk/interpro/entry/IPR018060 InterPro IPR018062 http://www.ebi.ac.uk/interpro/entry/IPR018062 InterPro IPR020449 http://www.ebi.ac.uk/interpro/entry/IPR020449 KEGG_Gene ecj:JW1494 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1494 KEGG_Gene eco:b1499 http://www.genome.jp/dbget-bin/www_bget?eco:b1499 OMA HMGMNTG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HMGMNTG PRINTS PR00032 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00032 PROSITE PS00041 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00041 PROSITE PS01124 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01124 PSORT swissprot:YDEO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDEO_ECOLI PSORT-B swissprot:YDEO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDEO_ECOLI PSORT2 swissprot:YDEO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDEO_ECOLI Pfam PF12833 http://pfam.xfam.org/family/PF12833 Phobius swissprot:YDEO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDEO_ECOLI PhylomeDB P76135 http://phylomedb.org/?seqid=P76135 ProteinModelPortal P76135 http://www.proteinmodelportal.org/query/uniprot/P76135 PubMed 12399493 http://www.ncbi.nlm.nih.gov/pubmed/12399493 PubMed 12694615 http://www.ncbi.nlm.nih.gov/pubmed/12694615 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416016 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416016 RefSeq WP_000060495 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000060495 SMART SM00342 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00342 SMR P76135 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76135 STRING 511145.b1499 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1499&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 UniProtKB YDEO_ECOLI http://www.uniprot.org/uniprot/YDEO_ECOLI UniProtKB-AC P76135 http://www.uniprot.org/uniprot/P76135 charge swissprot:YDEO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDEO_ECOLI eggNOG COG2207 http://eggnogapi.embl.de/nog_data/html/tree/COG2207 eggNOG ENOG4105Z68 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105Z68 epestfind swissprot:YDEO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDEO_ECOLI garnier swissprot:YDEO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDEO_ECOLI helixturnhelix swissprot:YDEO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDEO_ECOLI hmoment swissprot:YDEO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDEO_ECOLI iep swissprot:YDEO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDEO_ECOLI inforesidue swissprot:YDEO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDEO_ECOLI octanol swissprot:YDEO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDEO_ECOLI pepcoil swissprot:YDEO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDEO_ECOLI pepdigest swissprot:YDEO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDEO_ECOLI pepinfo swissprot:YDEO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDEO_ECOLI pepnet swissprot:YDEO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDEO_ECOLI pepstats swissprot:YDEO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDEO_ECOLI pepwheel swissprot:YDEO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDEO_ECOLI pepwindow swissprot:YDEO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDEO_ECOLI sigcleave swissprot:YDEO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDEO_ECOLI ## Database ID URL or Descriptions # AltName SKP_ECOLI DNA-binding 17 kDa protein # AltName SKP_ECOLI Histone-like protein HLP-1 # AltName SKP_ECOLI Seventeen kilodalton protein # BioGrid 4263427 186 # CAUTION Was originally thought to bind DNA. It was probably an artifact due to the cationic nature of skp. {ECO 0000305}. # DOMAIN SKP_ECOLI Composed of a compact central beta-barrel domain with long alpha-helical extensions that form a three-pronged structure around an internal cavity. Substrate proteins may be bound in this cavity. # EcoGene EG10455 skp # FUNCTION SKP_ECOLI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm. Required for the efficient release of OmpA from the inner membrane, the maintenance of its solubility in the periplasm, and, in association with lipopolysaccharide (LPS), for the efficient folding and insertion of OmpA into the outer membrane. {ECO 0000269|PubMed 10455120, ECO 0000269|PubMed 11278858, ECO 0000269|PubMed 12509434, ECO 0000269|PubMed 8730870, ECO 0000269|PubMed 9914480}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoliWiki. # GO_function GO:0001530 lipopolysaccharide binding; IPI:EcoCyc. # GO_function GO:0051082 unfolded protein binding; IPI:EcoCyc. # GO_process GO:0006457 protein folding; IDA:EcoCyc. # GO_process GO:0022417 protein maturation by protein folding; IDA:CACAO. # GO_process GO:0032978 protein insertion into membrane from inner side; IDA:EcoCyc. # GO_process GO:0043165 Gram-negative-bacterium-type cell outer membrane assembly; IDA:EcoCyc. # GO_process GO:0050821 protein stabilization; IDA:EcoCyc. # GO_process GO:0051085 chaperone mediated protein folding requiring cofactor; IGI:EcoCyc. # GO_process GO:0065002 intracellular protein transmembrane transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0008289 lipid binding # GOslim_function GO:0051082 unfolded protein binding # GOslim_process GO:0006457 protein folding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0051604 protein maturation # GOslim_process GO:0055085 transmembrane transport # GOslim_process GO:0061024 membrane organization # IntAct P0AEU7 28 # InterPro IPR005632 Chaperone_Skp # InterPro IPR024930 Skp_domain # MISCELLANEOUS SKP_ECOLI Does not require ATP for its activity. # Organism SKP_ECOLI Escherichia coli (strain K12) # PATRIC 32115467 VBIEscCol129921_0185 # PDB 1SG2 X-ray; 2.35 A; A/B/C=20-161 # PDB 1U2M X-ray; 2.30 A; A/B/C=21-161 # PIR JT0304 DNEC17 # PIRSF PIRSF002094 OMP26_Skp # Pfam PF03938 OmpH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SKP_ECOLI Chaperone protein Skp # RefSeq NP_414720 NC_000913.3 # RefSeq WP_000758956 NZ_LN832404.1 # SIMILARITY Belongs to the Skp family. {ECO 0000305}. # SMART SM00935 OmpH # SUBCELLULAR LOCATION SKP_ECOLI Periplasm {ECO 0000269|PubMed 1838129, ECO 0000269|PubMed 8730870}. # SUBUNIT SKP_ECOLI Homotrimer. Interacts with OmpA. Interacts with PhoE during its translocation across the inner membrane, but, in contrast to OmpA, release of PhoE from the inner membrane is not dependent on skp. Interacts also with LamB, OmpC and OmpF. {ECO 0000269|PubMed 15101556, ECO 0000269|PubMed 15304217, ECO 0000269|PubMed 15361861}. # SUPFAM SSF111384 SSF111384 # eggNOG COG2825 LUCA # eggNOG ENOG4108RFI Bacteria BLAST swissprot:SKP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SKP_ECOLI BioCyc ECOL316407:JW0173-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0173-MONOMER BioCyc EcoCyc:EG10455-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10455-MONOMER BioCyc MetaCyc:EG10455-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10455-MONOMER COG COG2825 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2825 DIP DIP-36210N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36210N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1016/0014-5793(90)80169-J http://dx.doi.org/10.1016/0014-5793(90)80169-J DOI 10.1016/0378-1119(88)90014-5 http://dx.doi.org/10.1016/0378-1119(88)90014-5 DOI 10.1016/j.molcel.2004.07.023 http://dx.doi.org/10.1016/j.molcel.2004.07.023 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsmb828 http://dx.doi.org/10.1038/nsmb828 DOI 10.1046/j.1432-1327.1999.00010.x http://dx.doi.org/10.1046/j.1432-1327.1999.00010.x DOI 10.1074/jbc.274.35.24567 http://dx.doi.org/10.1074/jbc.274.35.24567 DOI 10.1074/jbc.M011194200 http://dx.doi.org/10.1074/jbc.M011194200 DOI 10.1074/jbc.M211177200 http://dx.doi.org/10.1074/jbc.M211177200 DOI 10.1111/j.1365-2958.1991.tb01990.x http://dx.doi.org/10.1111/j.1365-2958.1991.tb01990.x DOI 10.1111/j.1365-2958.1996.tb02473.x http://dx.doi.org/10.1111/j.1365-2958.1996.tb02473.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1515/BC.2004.032 http://dx.doi.org/10.1515/BC.2004.032 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M21118 http://www.ebi.ac.uk/ena/data/view/M21118 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EMBL X54797 http://www.ebi.ac.uk/ena/data/view/X54797 EMBL X75465 http://www.ebi.ac.uk/ena/data/view/X75465 EchoBASE EB0450 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0450 EcoGene EG10455 http://www.ecogene.org/geneInfo.php?eg_id=EG10455 EnsemblBacteria AAC73289 http://www.ensemblgenomes.org/id/AAC73289 EnsemblBacteria AAC73289 http://www.ensemblgenomes.org/id/AAC73289 EnsemblBacteria BAA77853 http://www.ensemblgenomes.org/id/BAA77853 EnsemblBacteria BAA77853 http://www.ensemblgenomes.org/id/BAA77853 EnsemblBacteria BAA77853 http://www.ensemblgenomes.org/id/BAA77853 EnsemblBacteria b0178 http://www.ensemblgenomes.org/id/b0178 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0001530 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001530 GO_function GO:0051082 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051082 GO_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GO_process GO:0022417 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022417 GO_process GO:0032978 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032978 GO_process GO:0043165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043165 GO_process GO:0050821 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050821 GO_process GO:0051085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051085 GO_process GO:0065002 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0065002 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0008289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289 GOslim_function GO:0051082 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051082 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_process GO:0061024 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024 GeneID 944861 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944861 HOGENOM HOG000261755 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261755&db=HOGENOM6 IntAct P0AEU7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEU7* InterPro IPR005632 http://www.ebi.ac.uk/interpro/entry/IPR005632 InterPro IPR024930 http://www.ebi.ac.uk/interpro/entry/IPR024930 KEGG_Gene ecj:JW0173 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0173 KEGG_Gene eco:b0178 http://www.genome.jp/dbget-bin/www_bget?eco:b0178 KEGG_Orthology KO:K06142 http://www.genome.jp/dbget-bin/www_bget?KO:K06142 MINT MINT-1229504 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1229504 OMA QAFDQDN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QAFDQDN PDB 1SG2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1SG2 PDB 1U2M http://www.ebi.ac.uk/pdbe-srv/view/entry/1U2M PDBsum 1SG2 http://www.ebi.ac.uk/pdbsum/1SG2 PDBsum 1U2M http://www.ebi.ac.uk/pdbsum/1U2M PSORT swissprot:SKP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SKP_ECOLI PSORT-B swissprot:SKP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SKP_ECOLI PSORT2 swissprot:SKP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SKP_ECOLI Pfam PF03938 http://pfam.xfam.org/family/PF03938 Phobius swissprot:SKP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SKP_ECOLI PhylomeDB P0AEU7 http://phylomedb.org/?seqid=P0AEU7 ProteinModelPortal P0AEU7 http://www.proteinmodelportal.org/query/uniprot/P0AEU7 PubMed 10455120 http://www.ncbi.nlm.nih.gov/pubmed/10455120 PubMed 11278858 http://www.ncbi.nlm.nih.gov/pubmed/11278858 PubMed 12509434 http://www.ncbi.nlm.nih.gov/pubmed/12509434 PubMed 15101556 http://www.ncbi.nlm.nih.gov/pubmed/15101556 PubMed 15304217 http://www.ncbi.nlm.nih.gov/pubmed/15304217 PubMed 15361861 http://www.ncbi.nlm.nih.gov/pubmed/15361861 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1838129 http://www.ncbi.nlm.nih.gov/pubmed/1838129 PubMed 1987124 http://www.ncbi.nlm.nih.gov/pubmed/1987124 PubMed 1991717 http://www.ncbi.nlm.nih.gov/pubmed/1991717 PubMed 2318304 http://www.ncbi.nlm.nih.gov/pubmed/2318304 PubMed 2843433 http://www.ncbi.nlm.nih.gov/pubmed/2843433 PubMed 8730870 http://www.ncbi.nlm.nih.gov/pubmed/8730870 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9914480 http://www.ncbi.nlm.nih.gov/pubmed/9914480 RefSeq NP_414720 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414720 RefSeq WP_000758956 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000758956 SMART SM00935 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00935 SMR P0AEU7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEU7 STRING 511145.b0178 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0178&targetmode=cogs STRING COG2825 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2825&targetmode=cogs SUPFAM SSF111384 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF111384 UniProtKB SKP_ECOLI http://www.uniprot.org/uniprot/SKP_ECOLI UniProtKB-AC P0AEU7 http://www.uniprot.org/uniprot/P0AEU7 charge swissprot:SKP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SKP_ECOLI eggNOG COG2825 http://eggnogapi.embl.de/nog_data/html/tree/COG2825 eggNOG ENOG4108RFI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108RFI epestfind swissprot:SKP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SKP_ECOLI garnier swissprot:SKP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SKP_ECOLI helixturnhelix swissprot:SKP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SKP_ECOLI hmoment swissprot:SKP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SKP_ECOLI iep swissprot:SKP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SKP_ECOLI inforesidue swissprot:SKP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SKP_ECOLI octanol swissprot:SKP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SKP_ECOLI pepcoil swissprot:SKP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SKP_ECOLI pepdigest swissprot:SKP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SKP_ECOLI pepinfo swissprot:SKP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SKP_ECOLI pepnet swissprot:SKP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SKP_ECOLI pepstats swissprot:SKP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SKP_ECOLI pepwheel swissprot:SKP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SKP_ECOLI pepwindow swissprot:SKP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SKP_ECOLI sigcleave swissprot:SKP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SKP_ECOLI ## Database ID URL or Descriptions # AltName FKBB_ECOLI Rotamase # BioGrid 4259639 11 # CATALYTIC ACTIVITY FKBB_ECOLI Peptidylproline (omega=180) = peptidylproline (omega=0). # ENZYME REGULATION FKBB_ECOLI Strongly inhibited by FK506. # EcoGene EG12503 fklB # FUNCTION FKBB_ECOLI PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_function GO:0003755 peptidyl-prolyl cis-trans isomerase activity; IBA:GO_Central. # GO_function GO:0005528 FK506 binding; IBA:GO_Central. # GO_process GO:0061077 chaperone-mediated protein folding; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0006457 protein folding # Gene3D 1.10.287.460 -; 1. # INTERACTION FKBB_ECOLI Self; NbExp=3; IntAct=EBI-369295, EBI-369295; # IntAct P0A9L3 11 # InterPro IPR000774 PPIase_FKBP_N # InterPro IPR001179 PPIase_FKBP_dom # InterPro IPR023566 PPIase_FKBP # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03110 Chaperones and folding catalysts # MASS SPECTROMETRY Mass=22084; Mass_error=1.47; Method=Electrospray; Range=2-206; Evidence={ECO:0000269|PubMed 8703024}; # Organism FKBB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10516 PTHR10516; 2 # PATRIC 32123989 VBIEscCol129921_4339 # PROSITE PS50059 FKBP_PPIASE # Pfam PF00254 FKBP_C # Pfam PF01346 FKBP_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FKBB_ECOLI FKBP-type 22 kDa peptidyl-prolyl cis-trans isomerase # RefSeq NP_418628 NC_000913.3 # RefSeq WP_000211225 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97103.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the FKBP-type PPIase family. {ECO 0000305}. # SIMILARITY Contains 1 PPIase FKBP-type domain. {ECO:0000255|PROSITE-ProRule PRU00277}. # SUBCELLULAR LOCATION FKBB_ECOLI Cytoplasm. Periplasm. Note=According to PubMed 7610040 it is periplasmic. # SUBUNIT FKBB_ECOLI Homodimer. # eggNOG COG0545 LUCA # eggNOG ENOG4108V1T Bacteria BLAST swissprot:FKBB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FKBB_ECOLI BioCyc ECOL316407:JW5746-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5746-MONOMER BioCyc EcoCyc:G7865-MONOMER http://biocyc.org/getid?id=EcoCyc:G7865-MONOMER BioCyc MetaCyc:G7865-MONOMER http://biocyc.org/getid?id=MetaCyc:G7865-MONOMER COG COG0545 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0545 DIP DIP-31854N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31854N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.271.36.22130 http://dx.doi.org/10.1074/jbc.271.36.22130 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.2.1.8 http://www.genome.jp/dbget-bin/www_bget?EC:5.2.1.8 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 5.2.1.8 http://enzyme.expasy.org/EC/5.2.1.8 EchoBASE EB2396 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2396 EcoGene EG12503 http://www.ecogene.org/geneInfo.php?eg_id=EG12503 EnsemblBacteria AAC77164 http://www.ensemblgenomes.org/id/AAC77164 EnsemblBacteria AAC77164 http://www.ensemblgenomes.org/id/AAC77164 EnsemblBacteria BAE78208 http://www.ensemblgenomes.org/id/BAE78208 EnsemblBacteria BAE78208 http://www.ensemblgenomes.org/id/BAE78208 EnsemblBacteria BAE78208 http://www.ensemblgenomes.org/id/BAE78208 EnsemblBacteria b4207 http://www.ensemblgenomes.org/id/b4207 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0003755 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003755 GO_function GO:0005528 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005528 GO_process GO:0061077 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061077 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 Gene3D 1.10.287.460 http://www.cathdb.info/version/latest/superfamily/1.10.287.460 GeneID 948726 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948726 HOGENOM HOG000154888 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000154888&db=HOGENOM6 InParanoid P0A9L3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9L3 IntAct P0A9L3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9L3* IntEnz 5.2.1.8 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.2.1.8 InterPro IPR000774 http://www.ebi.ac.uk/interpro/entry/IPR000774 InterPro IPR001179 http://www.ebi.ac.uk/interpro/entry/IPR001179 InterPro IPR023566 http://www.ebi.ac.uk/interpro/entry/IPR023566 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW5746 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5746 KEGG_Gene eco:b4207 http://www.genome.jp/dbget-bin/www_bget?eco:b4207 KEGG_Orthology KO:K03773 http://www.genome.jp/dbget-bin/www_bget?KO:K03773 MINT MINT-1238607 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1238607 OMA WKLYIPQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WKLYIPQ PANTHER PTHR10516 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10516 PROSITE PS50059 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50059 PSORT swissprot:FKBB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FKBB_ECOLI PSORT-B swissprot:FKBB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FKBB_ECOLI PSORT2 swissprot:FKBB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FKBB_ECOLI Pfam PF00254 http://pfam.xfam.org/family/PF00254 Pfam PF01346 http://pfam.xfam.org/family/PF01346 Phobius swissprot:FKBB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FKBB_ECOLI PhylomeDB P0A9L3 http://phylomedb.org/?seqid=P0A9L3 ProteinModelPortal P0A9L3 http://www.proteinmodelportal.org/query/uniprot/P0A9L3 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8703024 http://www.ncbi.nlm.nih.gov/pubmed/8703024 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_418628 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418628 RefSeq WP_000211225 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000211225 SMR P0A9L3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9L3 STRING 511145.b4207 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4207&targetmode=cogs STRING COG0545 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0545&targetmode=cogs SWISS-2DPAGE P0A9L3 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A9L3 UniProtKB FKBB_ECOLI http://www.uniprot.org/uniprot/FKBB_ECOLI UniProtKB-AC P0A9L3 http://www.uniprot.org/uniprot/P0A9L3 charge swissprot:FKBB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FKBB_ECOLI eggNOG COG0545 http://eggnogapi.embl.de/nog_data/html/tree/COG0545 eggNOG ENOG4108V1T http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108V1T epestfind swissprot:FKBB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FKBB_ECOLI garnier swissprot:FKBB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FKBB_ECOLI helixturnhelix swissprot:FKBB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FKBB_ECOLI hmoment swissprot:FKBB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FKBB_ECOLI iep swissprot:FKBB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FKBB_ECOLI inforesidue swissprot:FKBB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FKBB_ECOLI octanol swissprot:FKBB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FKBB_ECOLI pepcoil swissprot:FKBB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FKBB_ECOLI pepdigest swissprot:FKBB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FKBB_ECOLI pepinfo swissprot:FKBB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FKBB_ECOLI pepnet swissprot:FKBB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FKBB_ECOLI pepstats swissprot:FKBB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FKBB_ECOLI pepwheel swissprot:FKBB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FKBB_ECOLI pepwindow swissprot:FKBB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FKBB_ECOLI sigcleave swissprot:FKBB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FKBB_ECOLI ## Database ID URL or Descriptions # BioGrid 4263203 9 # EcoGene EG14293 sirB2 # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR007360 SirB # Organism SIRB2_ECOLI Escherichia coli (strain K12) # PATRIC 32117678 VBIEscCol129921_1261 # PIR I83571 I83571 # PIRSF PIRSF005610 SirB # Pfam PF04247 SirB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SIRB2_ECOLI Protein sirB2 # RefSeq NP_415731 NC_000913.3 # RefSeq WP_000200374 NZ_LN832404.1 # SUBCELLULAR LOCATION SIRB2_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG COG3094 LUCA # eggNOG ENOG4108YY7 Bacteria BLAST swissprot:SIRB2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SIRB2_ECOLI BioCyc ECOL316407:JW1204-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1204-MONOMER BioCyc EcoCyc:G6630-MONOMER http://biocyc.org/getid?id=EcoCyc:G6630-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18555 http://www.ebi.ac.uk/ena/data/view/U18555 EchoBASE EB4041 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4041 EcoGene EG14293 http://www.ecogene.org/geneInfo.php?eg_id=EG14293 EnsemblBacteria AAC74297 http://www.ensemblgenomes.org/id/AAC74297 EnsemblBacteria AAC74297 http://www.ensemblgenomes.org/id/AAC74297 EnsemblBacteria BAA36071 http://www.ensemblgenomes.org/id/BAA36071 EnsemblBacteria BAA36071 http://www.ensemblgenomes.org/id/BAA36071 EnsemblBacteria BAA36071 http://www.ensemblgenomes.org/id/BAA36071 EnsemblBacteria b1213 http://www.ensemblgenomes.org/id/b1213 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 945781 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945781 HOGENOM HOG000270268 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000270268&db=HOGENOM6 InParanoid Q46755 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46755 IntAct Q46755 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46755* InterPro IPR007360 http://www.ebi.ac.uk/interpro/entry/IPR007360 KEGG_Gene ecj:JW1204 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1204 KEGG_Gene eco:b1213 http://www.genome.jp/dbget-bin/www_bget?eco:b1213 OMA ITHFYPF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ITHFYPF PSORT swissprot:SIRB2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SIRB2_ECOLI PSORT-B swissprot:SIRB2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SIRB2_ECOLI PSORT2 swissprot:SIRB2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SIRB2_ECOLI Pfam PF04247 http://pfam.xfam.org/family/PF04247 Phobius swissprot:SIRB2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SIRB2_ECOLI ProteinModelPortal Q46755 http://www.proteinmodelportal.org/query/uniprot/Q46755 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7543480 http://www.ncbi.nlm.nih.gov/pubmed/7543480 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415731 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415731 RefSeq WP_000200374 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000200374 STRING 511145.b1213 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1213&targetmode=cogs UniProtKB SIRB2_ECOLI http://www.uniprot.org/uniprot/SIRB2_ECOLI UniProtKB-AC Q46755 http://www.uniprot.org/uniprot/Q46755 charge swissprot:SIRB2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SIRB2_ECOLI eggNOG COG3094 http://eggnogapi.embl.de/nog_data/html/tree/COG3094 eggNOG ENOG4108YY7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108YY7 epestfind swissprot:SIRB2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SIRB2_ECOLI garnier swissprot:SIRB2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SIRB2_ECOLI helixturnhelix swissprot:SIRB2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SIRB2_ECOLI hmoment swissprot:SIRB2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SIRB2_ECOLI iep swissprot:SIRB2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SIRB2_ECOLI inforesidue swissprot:SIRB2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SIRB2_ECOLI octanol swissprot:SIRB2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SIRB2_ECOLI pepcoil swissprot:SIRB2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SIRB2_ECOLI pepdigest swissprot:SIRB2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SIRB2_ECOLI pepinfo swissprot:SIRB2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SIRB2_ECOLI pepnet swissprot:SIRB2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SIRB2_ECOLI pepstats swissprot:SIRB2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SIRB2_ECOLI pepwheel swissprot:SIRB2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SIRB2_ECOLI pepwindow swissprot:SIRB2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SIRB2_ECOLI sigcleave swissprot:SIRB2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SIRB2_ECOLI ## Database ID URL or Descriptions # BioGrid 4262369 17 # CDD cd07377 WHTH_GntR # EcoGene EG12998 glcC # FUNCTION GLCC_ECOLI Activator for the glycolate oxidation locus. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # Gene3D 1.20.120.530 -; 1. # INTERACTION GLCC_ECOLI P23893 hemL; NbExp=4; IntAct=EBI-1115389, EBI-909193; P76335 yedS; NbExp=2; IntAct=EBI-1115389, EBI-1119674; # IntAct P0ACL5 65 # InterPro IPR000524 Tscrpt_reg_HTH_GntR # InterPro IPR008920 TF_FadR/GntR_C # InterPro IPR011711 GntR_C # InterPro IPR011991 WHTH_DNA-bd_dom # KEGG_Brite ko03000 Transcription factors # Organism GLCC_ECOLI Escherichia coli (strain K12) # PATRIC 32121376 VBIEscCol129921_3075 # PIR B65084 B65084 # PRINTS PR00035 HTHGNTR # PROSITE PS50949 HTH_GNTR # Pfam PF00392 GntR # Pfam PF07729 FCD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLCC_ECOLI Glc operon transcriptional activator # RefSeq NP_417454 NC_000913.3 # RefSeq WP_001297764 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA69147.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Contains 1 HTH gntR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00307}. # SMART SM00345 HTH_GNTR # SMART SM00895 FCD # SUPFAM SSF46785 SSF46785 # SUPFAM SSF48008 SSF48008 # eggNOG COG2186 LUCA # eggNOG ENOG4108KWP Bacteria BLAST swissprot:GLCC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLCC_ECOLI BioCyc ECOL316407:JW2947-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2947-MONOMER BioCyc EcoCyc:G7546-MONOMER http://biocyc.org/getid?id=EcoCyc:G7546-MONOMER COG COG2186 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2186 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L43490 http://www.ebi.ac.uk/ena/data/view/L43490 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2821 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2821 EcoGene EG12998 http://www.ecogene.org/geneInfo.php?eg_id=EG12998 EnsemblBacteria AAC76016 http://www.ensemblgenomes.org/id/AAC76016 EnsemblBacteria AAC76016 http://www.ensemblgenomes.org/id/AAC76016 EnsemblBacteria BAE77041 http://www.ensemblgenomes.org/id/BAE77041 EnsemblBacteria BAE77041 http://www.ensemblgenomes.org/id/BAE77041 EnsemblBacteria BAE77041 http://www.ensemblgenomes.org/id/BAE77041 EnsemblBacteria b2980 http://www.ensemblgenomes.org/id/b2980 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 1.20.120.530 http://www.cathdb.info/version/latest/superfamily/1.20.120.530 GeneID 947466 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947466 HOGENOM HOG000273991 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000273991&db=HOGENOM6 InParanoid P0ACL5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACL5 IntAct P0ACL5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACL5* InterPro IPR000524 http://www.ebi.ac.uk/interpro/entry/IPR000524 InterPro IPR008920 http://www.ebi.ac.uk/interpro/entry/IPR008920 InterPro IPR011711 http://www.ebi.ac.uk/interpro/entry/IPR011711 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW2947 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2947 KEGG_Gene eco:b2980 http://www.genome.jp/dbget-bin/www_bget?eco:b2980 KEGG_Orthology KO:K11474 http://www.genome.jp/dbget-bin/www_bget?KO:K11474 OMA MMHLLGS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MMHLLGS PRINTS PR00035 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00035 PROSITE PS50949 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50949 PSORT swissprot:GLCC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLCC_ECOLI PSORT-B swissprot:GLCC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLCC_ECOLI PSORT2 swissprot:GLCC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLCC_ECOLI Pfam PF00392 http://pfam.xfam.org/family/PF00392 Pfam PF07729 http://pfam.xfam.org/family/PF07729 Phobius swissprot:GLCC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLCC_ECOLI PhylomeDB P0ACL5 http://phylomedb.org/?seqid=P0ACL5 ProteinModelPortal P0ACL5 http://www.proteinmodelportal.org/query/uniprot/P0ACL5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8606183 http://www.ncbi.nlm.nih.gov/pubmed/8606183 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417454 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417454 RefSeq WP_001297764 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001297764 SMART SM00345 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00345 SMART SM00895 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00895 SMR P0ACL5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACL5 STRING 511145.b2980 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2980&targetmode=cogs STRING COG2186 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2186&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SUPFAM SSF48008 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48008 UniProtKB GLCC_ECOLI http://www.uniprot.org/uniprot/GLCC_ECOLI UniProtKB-AC P0ACL5 http://www.uniprot.org/uniprot/P0ACL5 charge swissprot:GLCC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLCC_ECOLI eggNOG COG2186 http://eggnogapi.embl.de/nog_data/html/tree/COG2186 eggNOG ENOG4108KWP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108KWP epestfind swissprot:GLCC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLCC_ECOLI garnier swissprot:GLCC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLCC_ECOLI helixturnhelix swissprot:GLCC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLCC_ECOLI hmoment swissprot:GLCC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLCC_ECOLI iep swissprot:GLCC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLCC_ECOLI inforesidue swissprot:GLCC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLCC_ECOLI octanol swissprot:GLCC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLCC_ECOLI pepcoil swissprot:GLCC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLCC_ECOLI pepdigest swissprot:GLCC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLCC_ECOLI pepinfo swissprot:GLCC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLCC_ECOLI pepnet swissprot:GLCC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLCC_ECOLI pepstats swissprot:GLCC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLCC_ECOLI pepwheel swissprot:GLCC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLCC_ECOLI pepwindow swissprot:GLCC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLCC_ECOLI sigcleave swissprot:GLCC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLCC_ECOLI ## Database ID URL or Descriptions # BioGrid 4261499 12 # EcoGene EG13556 yagQ # GO_function GO:0043546 molybdopterin cofactor binding; IDA:EcoCyc. # GOslim_function GO:0003674 molecular_function # IntAct P77183 4 # InterPro IPR003777 XdhC_CoxI # InterPro IPR027051 XdhC_Rossmann_dom # Organism YAGQ_ECOLI Escherichia coli (strain K12) # PATRIC 32115689 VBIEscCol129921_0287 # PIR C64754 C64754 # Pfam PF02625 XdhC_CoxI # Pfam PF13478 XdhC_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAGQ_ECOLI Uncharacterized protein YagQ # RefSeq NP_414817 NC_000913.3 # RefSeq WP_000121359 NZ_LN832404.1 # eggNOG COG1975 LUCA # eggNOG ENOG4107XAN Bacteria BLAST swissprot:YAGQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAGQ_ECOLI BioCyc ECOL316407:JW0277-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0277-MONOMER BioCyc EcoCyc:G6154-MONOMER http://biocyc.org/getid?id=EcoCyc:G6154-MONOMER COG COG1975 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1975 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB3326 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3326 EcoGene EG13556 http://www.ecogene.org/geneInfo.php?eg_id=EG13556 EnsemblBacteria AAC73386 http://www.ensemblgenomes.org/id/AAC73386 EnsemblBacteria AAC73386 http://www.ensemblgenomes.org/id/AAC73386 EnsemblBacteria BAE76067 http://www.ensemblgenomes.org/id/BAE76067 EnsemblBacteria BAE76067 http://www.ensemblgenomes.org/id/BAE76067 EnsemblBacteria BAE76067 http://www.ensemblgenomes.org/id/BAE76067 EnsemblBacteria b0283 http://www.ensemblgenomes.org/id/b0283 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0043546 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043546 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GeneID 945010 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945010 HOGENOM HOG000244666 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000244666&db=HOGENOM6 InParanoid P77183 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77183 IntAct P77183 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77183* InterPro IPR003777 http://www.ebi.ac.uk/interpro/entry/IPR003777 InterPro IPR027051 http://www.ebi.ac.uk/interpro/entry/IPR027051 KEGG_Gene ecj:JW0277 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0277 KEGG_Gene eco:b0283 http://www.genome.jp/dbget-bin/www_bget?eco:b0283 KEGG_Orthology KO:K07402 http://www.genome.jp/dbget-bin/www_bget?KO:K07402 OMA DRRSCVV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DRRSCVV PSORT swissprot:YAGQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAGQ_ECOLI PSORT-B swissprot:YAGQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAGQ_ECOLI PSORT2 swissprot:YAGQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAGQ_ECOLI Pfam PF02625 http://pfam.xfam.org/family/PF02625 Pfam PF13478 http://pfam.xfam.org/family/PF13478 Phobius swissprot:YAGQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAGQ_ECOLI PhylomeDB P77183 http://phylomedb.org/?seqid=P77183 ProteinModelPortal P77183 http://www.proteinmodelportal.org/query/uniprot/P77183 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414817 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414817 RefSeq WP_000121359 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000121359 SMR P77183 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77183 STRING 511145.b0283 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0283&targetmode=cogs STRING COG1975 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1975&targetmode=cogs UniProtKB YAGQ_ECOLI http://www.uniprot.org/uniprot/YAGQ_ECOLI UniProtKB-AC P77183 http://www.uniprot.org/uniprot/P77183 charge swissprot:YAGQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAGQ_ECOLI eggNOG COG1975 http://eggnogapi.embl.de/nog_data/html/tree/COG1975 eggNOG ENOG4107XAN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107XAN epestfind swissprot:YAGQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAGQ_ECOLI garnier swissprot:YAGQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAGQ_ECOLI helixturnhelix swissprot:YAGQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAGQ_ECOLI hmoment swissprot:YAGQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAGQ_ECOLI iep swissprot:YAGQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAGQ_ECOLI inforesidue swissprot:YAGQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAGQ_ECOLI octanol swissprot:YAGQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAGQ_ECOLI pepcoil swissprot:YAGQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAGQ_ECOLI pepdigest swissprot:YAGQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAGQ_ECOLI pepinfo swissprot:YAGQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAGQ_ECOLI pepnet swissprot:YAGQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAGQ_ECOLI pepstats swissprot:YAGQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAGQ_ECOLI pepwheel swissprot:YAGQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAGQ_ECOLI pepwindow swissprot:YAGQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAGQ_ECOLI sigcleave swissprot:YAGQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAGQ_ECOLI ## Database ID URL or Descriptions # AltName GALR_ECOLI Galactose operon repressor # BioGrid 4262964 15 # CDD cd01392 HTH_LacI # EcoGene EG10364 galR # FUNCTION GALR_ECOLI Repressor of the galactose operon. Binds galactose as an inducer. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_process GO:0006012 galactose metabolic process; IEA:UniProtKB-UniPathway. # GO_process GO:0006351 transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.260.40 -; 1. # INTERACTION GALR_ECOLI Self; NbExp=3; IntAct=EBI-556902, EBI-556902; P25748 galS; NbExp=5; IntAct=EBI-556902, EBI-1117006; # IntAct P03024 3 # InterPro IPR000843 HTH_LacI # InterPro IPR010982 Lambda_DNA-bd_dom # InterPro IPR028082 Peripla_BP_I # KEGG_Brite ko03000 Transcription factors # Organism GALR_ECOLI Escherichia coli (strain K12) # PATHWAY GALR_ECOLI Carbohydrate metabolism; galactose metabolism [regulation]. # PATRIC 32121092 VBIEscCol129921_2935 # PIR A93910 RPECG # PRINTS PR00036 HTHLACI # PROSITE PS00356 HTH_LACI_1 # PROSITE PS50932 HTH_LACI_2 # Pfam PF00356 LacI # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GALR_ECOLI HTH-type transcriptional regulator GalR # RefSeq NP_417314 NC_000913.3 # RefSeq WP_000201063 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lacI-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00111}. # SMART SM00354 HTH_LACI # SUBUNIT GALR_ECOLI Homodimer. # SUPFAM SSF47413 SSF47413 # SUPFAM SSF53822 SSF53822 # eggNOG COG1609 LUCA # eggNOG ENOG41060NJ Bacteria BLAST swissprot:GALR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GALR_ECOLI BioCyc ECOL316407:JW2805-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2805-MONOMER BioCyc EcoCyc:PD03028 http://biocyc.org/getid?id=EcoCyc:PD03028 COG COG1609 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1609 DIP DIP-9733N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9733N DOI 10.1016/S0022-2836(83)80021-7 http://dx.doi.org/10.1016/S0022-2836(83)80021-7 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.79.8.2427 http://dx.doi.org/10.1073/pnas.79.8.2427 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01614 http://www.ebi.ac.uk/ena/data/view/J01614 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 EMBL V00280 http://www.ebi.ac.uk/ena/data/view/V00280 EchoBASE EB0359 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0359 EcoGene EG10364 http://www.ecogene.org/geneInfo.php?eg_id=EG10364 EnsemblBacteria AAC75876 http://www.ensemblgenomes.org/id/AAC75876 EnsemblBacteria AAC75876 http://www.ensemblgenomes.org/id/AAC75876 EnsemblBacteria BAE76906 http://www.ensemblgenomes.org/id/BAE76906 EnsemblBacteria BAE76906 http://www.ensemblgenomes.org/id/BAE76906 EnsemblBacteria BAE76906 http://www.ensemblgenomes.org/id/BAE76906 EnsemblBacteria b2837 http://www.ensemblgenomes.org/id/b2837 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006012 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006012 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.260.40 http://www.cathdb.info/version/latest/superfamily/1.10.260.40 GeneID 947314 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947314 HOGENOM HOG000220179 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220179&db=HOGENOM6 InParanoid P03024 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P03024 IntAct P03024 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P03024* InterPro IPR000843 http://www.ebi.ac.uk/interpro/entry/IPR000843 InterPro IPR010982 http://www.ebi.ac.uk/interpro/entry/IPR010982 InterPro IPR028082 http://www.ebi.ac.uk/interpro/entry/IPR028082 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW2805 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2805 KEGG_Gene eco:b2837 http://www.genome.jp/dbget-bin/www_bget?eco:b2837 KEGG_Orthology KO:K02529 http://www.genome.jp/dbget-bin/www_bget?KO:K02529 MINT MINT-1295860 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1295860 OMA LLINNRC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LLINNRC PRINTS PR00036 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00036 PROSITE PS00356 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00356 PROSITE PS50932 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50932 PSORT swissprot:GALR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GALR_ECOLI PSORT-B swissprot:GALR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GALR_ECOLI PSORT2 swissprot:GALR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GALR_ECOLI Pfam PF00356 http://pfam.xfam.org/family/PF00356 Phobius swissprot:GALR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GALR_ECOLI PhylomeDB P03024 http://phylomedb.org/?seqid=P03024 ProteinModelPortal P03024 http://www.proteinmodelportal.org/query/uniprot/P03024 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6283521 http://www.ncbi.nlm.nih.gov/pubmed/6283521 PubMed 6350601 http://www.ncbi.nlm.nih.gov/pubmed/6350601 PubMed 8188660 http://www.ncbi.nlm.nih.gov/pubmed/8188660 PubMed 8982002 http://www.ncbi.nlm.nih.gov/pubmed/8982002 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417314 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417314 RefSeq WP_000201063 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000201063 SMART SM00354 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00354 SMR P03024 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P03024 STRING 511145.b2837 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2837&targetmode=cogs STRING COG1609 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1609&targetmode=cogs SUPFAM SSF47413 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47413 SUPFAM SSF53822 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822 UniProtKB GALR_ECOLI http://www.uniprot.org/uniprot/GALR_ECOLI UniProtKB-AC P03024 http://www.uniprot.org/uniprot/P03024 charge swissprot:GALR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GALR_ECOLI eggNOG COG1609 http://eggnogapi.embl.de/nog_data/html/tree/COG1609 eggNOG ENOG41060NJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG41060NJ epestfind swissprot:GALR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GALR_ECOLI garnier swissprot:GALR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GALR_ECOLI helixturnhelix swissprot:GALR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GALR_ECOLI hmoment swissprot:GALR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GALR_ECOLI iep swissprot:GALR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GALR_ECOLI inforesidue swissprot:GALR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GALR_ECOLI octanol swissprot:GALR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GALR_ECOLI pepcoil swissprot:GALR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GALR_ECOLI pepdigest swissprot:GALR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GALR_ECOLI pepinfo swissprot:GALR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GALR_ECOLI pepnet swissprot:GALR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GALR_ECOLI pepstats swissprot:GALR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GALR_ECOLI pepwheel swissprot:GALR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GALR_ECOLI pepwindow swissprot:GALR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GALR_ECOLI sigcleave swissprot:GALR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GALR_ECOLI ## Database ID URL or Descriptions # BioGrid 4260945 9 # EcoGene EG11914 eptC # FUNCTION EPTC_ECOLI Catalyzes the addition of a phosphoethanolamine moiety to the outer membrane lipopolysaccharide core. {ECO 0000250}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0008484 sulfuric ester hydrolase activity; IEA:InterPro. # GO_function GO:0016776 phosphotransferase activity, phosphate group as acceptor; IMP:EcoCyc. # GO_process GO:0009244 lipopolysaccharide core region biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.720.10 -; 1. # IntAct P0CB39 2 # InterPro IPR000917 Sulfatase_N # InterPro IPR012549 DUF1705 # InterPro IPR017849 Alkaline_Pase-like_a/b/a # InterPro IPR017850 Alkaline_phosphatase_core # Organism EPTC_ECOLI Escherichia coli (strain K12) # PATHWAY EPTC_ECOLI Bacterial outer membrane biogenesis; LPS core biosynthesis. # PATRIC 32123431 VBIEscCol129921_4076 # PIR F65202 F65202 # Pfam PF00884 Sulfatase # Pfam PF08019 DUF1705 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EPTC_ECOLI Phosphoethanolamine transferase EptC # RefSeq NP_418390 NC_000913.3 # RefSeq WP_000556306 NZ_LN832404.1 # SIMILARITY Belongs to the phosphoethanolamine transferase family. EptC/CptA subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION EPTC_ECOLI Cell inner membrane {ECO 0000269|PubMed 16079137}; Multi-pass membrane protein {ECO 0000269|PubMed 16079137}. # SUBUNIT Forms a complex with an unidentified protein of approximately 36 kDa. {ECO:0000269|PubMed 16079137}. # SUPFAM SSF53649 SSF53649 # eggNOG COG2194 LUCA # eggNOG ENOG4105DIJ Bacteria BLAST swissprot:EPTC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EPTC_ECOLI BioCyc EcoCyc:EG11914-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11914-MONOMER BioCyc MetaCyc:EG11914-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11914-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.-.- http://www.genome.jp/dbget-bin/www_bget?EC:2.7.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.-.- http://enzyme.expasy.org/EC/2.7.-.- EchoBASE EB1858 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1858 EcoGene EG11914 http://www.ecogene.org/geneInfo.php?eg_id=EG11914 EnsemblBacteria AAC76937 http://www.ensemblgenomes.org/id/AAC76937 EnsemblBacteria AAC76937 http://www.ensemblgenomes.org/id/AAC76937 EnsemblBacteria BAE77356 http://www.ensemblgenomes.org/id/BAE77356 EnsemblBacteria BAE77356 http://www.ensemblgenomes.org/id/BAE77356 EnsemblBacteria BAE77356 http://www.ensemblgenomes.org/id/BAE77356 EnsemblBacteria b3955 http://www.ensemblgenomes.org/id/b3955 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008484 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008484 GO_function GO:0016776 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016776 GO_process GO:0009244 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009244 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.720.10 http://www.cathdb.info/version/latest/superfamily/3.40.720.10 GeneID 948458 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948458 HOGENOM HOG000126729 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126729&db=HOGENOM6 InParanoid P0CB39 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CB39 IntAct P0CB39 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0CB39* IntEnz 2.7 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7 InterPro IPR000917 http://www.ebi.ac.uk/interpro/entry/IPR000917 InterPro IPR012549 http://www.ebi.ac.uk/interpro/entry/IPR012549 InterPro IPR017849 http://www.ebi.ac.uk/interpro/entry/IPR017849 InterPro IPR017850 http://www.ebi.ac.uk/interpro/entry/IPR017850 KEGG_Gene ecj:JW3927 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3927 KEGG_Gene eco:b3955 http://www.genome.jp/dbget-bin/www_bget?eco:b3955 OMA MEPAVPW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MEPAVPW PSORT swissprot:EPTC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EPTC_ECOLI PSORT-B swissprot:EPTC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EPTC_ECOLI PSORT2 swissprot:EPTC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EPTC_ECOLI Pfam PF00884 http://pfam.xfam.org/family/PF00884 Pfam PF08019 http://pfam.xfam.org/family/PF08019 Phobius swissprot:EPTC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EPTC_ECOLI PhylomeDB P0CB39 http://phylomedb.org/?seqid=P0CB39 ProteinModelPortal P0CB39 http://www.proteinmodelportal.org/query/uniprot/P0CB39 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418390 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418390 RefSeq WP_000556306 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000556306 STRING 511145.b3955 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3955&targetmode=cogs SUPFAM SSF53649 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53649 UniProtKB EPTC_ECOLI http://www.uniprot.org/uniprot/EPTC_ECOLI UniProtKB-AC P0CB39 http://www.uniprot.org/uniprot/P0CB39 charge swissprot:EPTC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EPTC_ECOLI eggNOG COG2194 http://eggnogapi.embl.de/nog_data/html/tree/COG2194 eggNOG ENOG4105DIJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DIJ epestfind swissprot:EPTC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EPTC_ECOLI garnier swissprot:EPTC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EPTC_ECOLI helixturnhelix swissprot:EPTC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EPTC_ECOLI hmoment swissprot:EPTC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EPTC_ECOLI iep swissprot:EPTC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EPTC_ECOLI inforesidue swissprot:EPTC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EPTC_ECOLI octanol swissprot:EPTC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EPTC_ECOLI pepcoil swissprot:EPTC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EPTC_ECOLI pepdigest swissprot:EPTC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EPTC_ECOLI pepinfo swissprot:EPTC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EPTC_ECOLI pepnet swissprot:EPTC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EPTC_ECOLI pepstats swissprot:EPTC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EPTC_ECOLI pepwheel swissprot:EPTC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EPTC_ECOLI pepwindow swissprot:EPTC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EPTC_ECOLI sigcleave swissprot:EPTC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EPTC_ECOLI ## Database ID URL or Descriptions # AltName SPEB_ECOLI Agmatine ureohydrolase # BioGrid 4260910 13 # CATALYTIC ACTIVITY SPEB_ECOLI Agmatine + H(2)O = putrescine + urea. # COFACTOR SPEB_ECOLI Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 10329468}; # ENZYME REGULATION SPEB_ECOLI The expression of auh activity is antagonistically regulated by cyclic AMP and agmatine. In the presence of the cAMP receptor protein, cAMP represses the expression of AUH, while agmatine induces it. # EcoGene EG10960 speB # FUNCTION SPEB_ECOLI Catalyzes the formation of putrescine from agmatine. {ECO 0000269|PubMed 10527864}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008783 agmatinase activity; IDA:EcoCyc. # GO_function GO:0030145 manganese ion binding; IDA:EcoCyc. # GO_process GO:0008295 spermidine biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0009446 putrescine biosynthetic process; IDA:EcoCyc. # GO_process GO:0033388 putrescine biosynthetic process from arginine; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.800.10 -; 1. # HAMAP MF_01418 SpeB # IntAct P60651 7 # InterPro IPR005925 Agmatinase-rel # InterPro IPR006035 Ureohydrolase # InterPro IPR020855 Ureohydrolase_Mn_BS # InterPro IPR023694 Agmatinase # InterPro IPR023696 Ureohydrolase_domain # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00330 Arginine and proline metabolism # Organism SPEB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11358 PTHR11358 # PATHWAY Amine and polyamine biosynthesis; putrescine biosynthesis via agmatine pathway; putrescine from agmatine step 1/1. # PATRIC 32121286 VBIEscCol129921_3031 # PIR C42604 C42604 # PIR G85950 G85950 # PIRSF PIRSF036979 Arginase # PROSITE PS01053 ARGINASE_1 # PROSITE PS51409 ARGINASE_2 # Pfam PF00491 Arginase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SPEB_ECOLI Agmatinase # RefSeq NP_417412 NC_000913.3 # RefSeq WP_000105566 NZ_LN832404.1 # SIMILARITY Belongs to the arginase family. Agmatinase subfamily. {ECO 0000305}. # TIGRFAMs TIGR01230 agmatinase # UniPathway UPA00534 UER00287 # eggNOG COG0010 LUCA # eggNOG ENOG4105CYW Bacteria BLAST swissprot:SPEB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SPEB_ECOLI BioCyc ECOL316407:JW2904-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2904-MONOMER BioCyc EcoCyc:AGMATIN-MONOMER http://biocyc.org/getid?id=EcoCyc:AGMATIN-MONOMER BioCyc MetaCyc:AGMATIN-MONOMER http://biocyc.org/getid?id=MetaCyc:AGMATIN-MONOMER COG COG0010 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0010 DIP DIP-10906N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10906N DOI 10.1006/bbrc.1999.0709 http://dx.doi.org/10.1006/bbrc.1999.0709 DOI 10.1006/bbrc.1999.1505 http://dx.doi.org/10.1006/bbrc.1999.1505 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.5.3.11 http://www.genome.jp/dbget-bin/www_bget?EC:3.5.3.11 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M31770 http://www.ebi.ac.uk/ena/data/view/M31770 EMBL M32363 http://www.ebi.ac.uk/ena/data/view/M32363 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 ENZYME 3.5.3.11 http://enzyme.expasy.org/EC/3.5.3.11 EchoBASE EB0953 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0953 EcoGene EG10960 http://www.ecogene.org/geneInfo.php?eg_id=EG10960 EnsemblBacteria AAC75974 http://www.ensemblgenomes.org/id/AAC75974 EnsemblBacteria AAC75974 http://www.ensemblgenomes.org/id/AAC75974 EnsemblBacteria BAE77000 http://www.ensemblgenomes.org/id/BAE77000 EnsemblBacteria BAE77000 http://www.ensemblgenomes.org/id/BAE77000 EnsemblBacteria BAE77000 http://www.ensemblgenomes.org/id/BAE77000 EnsemblBacteria b2937 http://www.ensemblgenomes.org/id/b2937 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008783 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008783 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_process GO:0008295 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008295 GO_process GO:0009446 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009446 GO_process GO:0033388 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033388 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.800.10 http://www.cathdb.info/version/latest/superfamily/3.40.800.10 GeneID 947715 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947715 HAMAP MF_01418 http://hamap.expasy.org/unirule/MF_01418 HOGENOM HOG000204320 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000204320&db=HOGENOM6 InParanoid P60651 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P60651 IntAct P60651 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P60651* IntEnz 3.5.3.11 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.3.11 InterPro IPR005925 http://www.ebi.ac.uk/interpro/entry/IPR005925 InterPro IPR006035 http://www.ebi.ac.uk/interpro/entry/IPR006035 InterPro IPR020855 http://www.ebi.ac.uk/interpro/entry/IPR020855 InterPro IPR023694 http://www.ebi.ac.uk/interpro/entry/IPR023694 InterPro IPR023696 http://www.ebi.ac.uk/interpro/entry/IPR023696 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2904 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2904 KEGG_Gene eco:b2937 http://www.genome.jp/dbget-bin/www_bget?eco:b2937 KEGG_Orthology KO:K01480 http://www.genome.jp/dbget-bin/www_bget?KO:K01480 KEGG_Pathway ko00330 http://www.genome.jp/kegg-bin/show_pathway?ko00330 KEGG_Reaction rn:R01157 http://www.genome.jp/dbget-bin/www_bget?rn:R01157 OMA YELTTIM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YELTTIM PANTHER PTHR11358 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11358 PROSITE PS01053 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01053 PROSITE PS51409 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51409 PSORT swissprot:SPEB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SPEB_ECOLI PSORT-B swissprot:SPEB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SPEB_ECOLI PSORT2 swissprot:SPEB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SPEB_ECOLI Pfam PF00491 http://pfam.xfam.org/family/PF00491 Phobius swissprot:SPEB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SPEB_ECOLI PhylomeDB P60651 http://phylomedb.org/?seqid=P60651 ProteinModelPortal P60651 http://www.proteinmodelportal.org/query/uniprot/P60651 PubMed 10329468 http://www.ncbi.nlm.nih.gov/pubmed/10329468 PubMed 10527864 http://www.ncbi.nlm.nih.gov/pubmed/10527864 PubMed 1310091 http://www.ncbi.nlm.nih.gov/pubmed/1310091 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2153656 http://www.ncbi.nlm.nih.gov/pubmed/2153656 PubMed 2198270 http://www.ncbi.nlm.nih.gov/pubmed/2198270 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417412 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417412 RefSeq WP_000105566 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000105566 SMR P60651 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P60651 STRING 511145.b2937 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2937&targetmode=cogs STRING COG0010 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0010&targetmode=cogs SWISS-2DPAGE P60651 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P60651 TIGRFAMs TIGR01230 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01230 UniProtKB SPEB_ECOLI http://www.uniprot.org/uniprot/SPEB_ECOLI UniProtKB-AC P60651 http://www.uniprot.org/uniprot/P60651 charge swissprot:SPEB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SPEB_ECOLI eggNOG COG0010 http://eggnogapi.embl.de/nog_data/html/tree/COG0010 eggNOG ENOG4105CYW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CYW epestfind swissprot:SPEB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SPEB_ECOLI garnier swissprot:SPEB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SPEB_ECOLI helixturnhelix swissprot:SPEB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SPEB_ECOLI hmoment swissprot:SPEB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SPEB_ECOLI iep swissprot:SPEB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SPEB_ECOLI inforesidue swissprot:SPEB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SPEB_ECOLI octanol swissprot:SPEB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SPEB_ECOLI pepcoil swissprot:SPEB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SPEB_ECOLI pepdigest swissprot:SPEB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SPEB_ECOLI pepinfo swissprot:SPEB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SPEB_ECOLI pepnet swissprot:SPEB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SPEB_ECOLI pepstats swissprot:SPEB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SPEB_ECOLI pepwheel swissprot:SPEB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SPEB_ECOLI pepwindow swissprot:SPEB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SPEB_ECOLI sigcleave swissprot:SPEB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SPEB_ECOLI ## Database ID URL or Descriptions # AltName PGPA_ECOLI Phosphatidylglycerolphosphate phosphatase A # BioGrid 4259341 300 # CATALYTIC ACTIVITY PGPA_ECOLI Phosphatidylglycerophosphate + H(2)O = phosphatidylglycerol + phosphate. {ECO 0000269|PubMed 20485265, ECO 0000269|PubMed 21148555, ECO 0000269|PubMed 2846510, ECO 0000269|PubMed 6296050}. # CDD cd06971 PgpA # COFACTOR PGPA_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 21148555}; # DISRUPTION PHENOTYPE PGPA_ECOLI Displays 7-10 fold higher levels of phosphatidylglycerophosphate (PGP) than wild-type. Simultaneous deletion of pgpA and pgpB leads to 40 times higher PGP levels compared to wild-type, while simultaneous deletion of pgpA and pgpC leads to almost 100 times higher PGP levels. Lethal when combined with the deletion of both pgpB and pgpC. {ECO 0000269|PubMed 21148555, ECO 0000269|PubMed 2846510, ECO 0000269|PubMed 6296050}. # EcoGene EG10704 pgpA # FUNCTION PGPA_ECOLI Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). {ECO 0000269|PubMed 20485265, ECO 0000269|PubMed 21148555, ECO 0000269|PubMed 2846510, ECO 0000269|PubMed 6296050}. # GO_component GO:0005886 plasma membrane; IDA:UniProtKB. # GO_component GO:0005887 integral component of plasma membrane; TAS:EcoCyc. # GO_function GO:0008962 phosphatidylglycerophosphatase activity; IDA:UniProtKB. # GO_function GO:0042577 lipid phosphatase activity; IDA:UniProtKB. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006655 phosphatidylglycerol biosynthetic process; IDA:UniProtKB. # GO_process GO:0009395 phospholipid catabolic process; IEA:UniProtKB-KW. # GO_process GO:0032026 response to magnesium ion; IDA:UniProtKB. # GO_process GO:0046474 glycerophospholipid biosynthetic process; IMP:EcoCyc. # GO_process GO:0046839 phospholipid dephosphorylation; IDA:UniProtKB. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 1.10.3760.10 -; 1. # InterPro IPR007686 YutG/PgpA # InterPro IPR026037 PgpA # InterPro IPR027416 YutG-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00564 Glycerophospholipid metabolism # Organism PGPA_ECOLI Escherichia coli (strain K12) # PATHWAY Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol step 2/2. # PATRIC 32115985 VBIEscCol129921_0434 # PIR A30192 PAECGA # PIR B64771 B64771 # PIRSF PIRSF006162 PgpA # Pfam PF04608 PgpA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PGPA_ECOLI Phosphatidylglycerophosphatase A # RefSeq NP_414952 NC_000913.3 # RefSeq WP_000154044 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA24325.1; Type=Frameshift; Positions=42; Note=In addition, due to translation of the incorrect DNA strand, an unrelated ORF was predicted.; Evidence={ECO 0000305}; # SUBCELLULAR LOCATION PGPA_ECOLI Cell inner membrane {ECO 0000269|PubMed 21148555}; Multi-pass membrane protein {ECO 0000269|PubMed 21148555}. # SUPFAM SSF101307 SSF101307 # UniPathway UPA00084 UER00504 # eggNOG COG1267 LUCA # eggNOG ENOG4108ZAI Bacteria BLAST swissprot:PGPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PGPA_ECOLI BioCyc ECOL316407:JW0408-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0408-MONOMER BioCyc EcoCyc:PGPPHOSPHAA-MONOMER http://biocyc.org/getid?id=EcoCyc:PGPPHOSPHAA-MONOMER BioCyc MetaCyc:PGPPHOSPHAA-MONOMER http://biocyc.org/getid?id=MetaCyc:PGPPHOSPHAA-MONOMER COG COG1267 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1267 DOI 10.1038/emboj.2010.98 http://dx.doi.org/10.1038/emboj.2010.98 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M110.199265 http://dx.doi.org/10.1074/jbc.M110.199265 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.3.27 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.27 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D17333 http://www.ebi.ac.uk/ena/data/view/D17333 EMBL M23546 http://www.ebi.ac.uk/ena/data/view/M23546 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 ENZYME 3.1.3.27 http://enzyme.expasy.org/EC/3.1.3.27 EchoBASE EB0698 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0698 EcoGene EG10704 http://www.ecogene.org/geneInfo.php?eg_id=EG10704 EnsemblBacteria AAC73521 http://www.ensemblgenomes.org/id/AAC73521 EnsemblBacteria AAC73521 http://www.ensemblgenomes.org/id/AAC73521 EnsemblBacteria BAE76198 http://www.ensemblgenomes.org/id/BAE76198 EnsemblBacteria BAE76198 http://www.ensemblgenomes.org/id/BAE76198 EnsemblBacteria BAE76198 http://www.ensemblgenomes.org/id/BAE76198 EnsemblBacteria b0418 http://www.ensemblgenomes.org/id/b0418 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0008962 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008962 GO_function GO:0042577 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042577 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006655 GO_process GO:0009395 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009395 GO_process GO:0032026 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032026 GO_process GO:0046474 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046474 GO_process GO:0046839 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046839 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 1.10.3760.10 http://www.cathdb.info/version/latest/superfamily/1.10.3760.10 GeneID 947542 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947542 HOGENOM HOG000256112 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000256112&db=HOGENOM6 InParanoid P18200 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P18200 IntEnz 3.1.3.27 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.27 InterPro IPR007686 http://www.ebi.ac.uk/interpro/entry/IPR007686 InterPro IPR026037 http://www.ebi.ac.uk/interpro/entry/IPR026037 InterPro IPR027416 http://www.ebi.ac.uk/interpro/entry/IPR027416 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0408 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0408 KEGG_Gene eco:b0418 http://www.genome.jp/dbget-bin/www_bget?eco:b0418 KEGG_Orthology KO:K01095 http://www.genome.jp/dbget-bin/www_bget?KO:K01095 KEGG_Pathway ko00564 http://www.genome.jp/kegg-bin/show_pathway?ko00564 KEGG_Reaction rn:R02029 http://www.genome.jp/dbget-bin/www_bget?rn:R02029 OMA VWDEIAG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VWDEIAG PSORT swissprot:PGPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PGPA_ECOLI PSORT-B swissprot:PGPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PGPA_ECOLI PSORT2 swissprot:PGPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PGPA_ECOLI Pfam PF04608 http://pfam.xfam.org/family/PF04608 Phobius swissprot:PGPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PGPA_ECOLI PhylomeDB P18200 http://phylomedb.org/?seqid=P18200 ProteinModelPortal P18200 http://www.proteinmodelportal.org/query/uniprot/P18200 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20485265 http://www.ncbi.nlm.nih.gov/pubmed/20485265 PubMed 21148555 http://www.ncbi.nlm.nih.gov/pubmed/21148555 PubMed 2846510 http://www.ncbi.nlm.nih.gov/pubmed/2846510 PubMed 6296050 http://www.ncbi.nlm.nih.gov/pubmed/6296050 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414952 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414952 RefSeq WP_000154044 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000154044 STRING 511145.b0418 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0418&targetmode=cogs STRING COG1267 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1267&targetmode=cogs SUPFAM SSF101307 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF101307 UniProtKB PGPA_ECOLI http://www.uniprot.org/uniprot/PGPA_ECOLI UniProtKB-AC P18200 http://www.uniprot.org/uniprot/P18200 charge swissprot:PGPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PGPA_ECOLI eggNOG COG1267 http://eggnogapi.embl.de/nog_data/html/tree/COG1267 eggNOG ENOG4108ZAI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZAI epestfind swissprot:PGPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PGPA_ECOLI garnier swissprot:PGPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PGPA_ECOLI helixturnhelix swissprot:PGPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PGPA_ECOLI hmoment swissprot:PGPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PGPA_ECOLI iep swissprot:PGPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PGPA_ECOLI inforesidue swissprot:PGPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PGPA_ECOLI octanol swissprot:PGPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PGPA_ECOLI pepcoil swissprot:PGPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PGPA_ECOLI pepdigest swissprot:PGPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PGPA_ECOLI pepinfo swissprot:PGPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PGPA_ECOLI pepnet swissprot:PGPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PGPA_ECOLI pepstats swissprot:PGPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PGPA_ECOLI pepwheel swissprot:PGPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PGPA_ECOLI pepwindow swissprot:PGPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PGPA_ECOLI sigcleave swissprot:PGPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PGPA_ECOLI ## Database ID URL or Descriptions # AltName SYGA_ECOLI Glycyl-tRNA synthetase alpha subunit # BioGrid 4259717 23 # CATALYTIC ACTIVITY SYGA_ECOLI ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly). # CDD cd00733 GlyRS_alpha_core # EcoGene EG10409 glyQ # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004820 glycine-tRNA ligase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006426 glycyl-tRNA aminoacylation; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0006520 cellular amino acid metabolic process # HAMAP MF_00254 Gly_tRNA_synth_alpha # INTERACTION SYGA_ECOLI P00961 glyS; NbExp=3; IntAct=EBI-551191, EBI-551400; # IntAct P00960 32 # InterPro IPR002310 Gly-tRNA_ligase_asu # InterPro IPR006194 Gly-tRNA-synth_heterodimer # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01007 Amino acid related enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # KEGG_Pathway ko00970 Aminoacyl-tRNA biosynthesis # Organism SYGA_ECOLI Escherichia coli (strain K12) # PATRIC 32122594 VBIEscCol129921_3674 # PIR B65155 SYECGA # PRINTS PR01044 TRNASYNTHGA # PROSITE PS50861 AA_TRNA_LIGASE_II_GLYAB # Pfam PF02091 tRNA-synt_2e # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SYGA_ECOLI Glycine--tRNA ligase alpha subunit # RefSeq NP_418017 NC_000913.3 # SIMILARITY Belongs to the class-II aminoacyl-tRNA synthetase family. {ECO 0000305}. # SUBCELLULAR LOCATION SYGA_ECOLI Cytoplasm. # SUBUNIT SYGA_ECOLI Tetramer of two alpha and two beta subunits. # TIGRFAMs TIGR00388 glyQ # eggNOG COG0752 LUCA BLAST swissprot:SYGA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SYGA_ECOLI BioCyc ECOL316407:JW3531-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3531-MONOMER BioCyc EcoCyc:GLYQ-MONOMER http://biocyc.org/getid?id=EcoCyc:GLYQ-MONOMER BioCyc MetaCyc:GLYQ-MONOMER http://biocyc.org/getid?id=MetaCyc:GLYQ-MONOMER COG COG0752 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0752 DIP DIP-9816N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9816N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.1.1.14 http://www.genome.jp/dbget-bin/www_bget?EC:6.1.1.14 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01622 http://www.ebi.ac.uk/ena/data/view/J01622 EMBL J01623 http://www.ebi.ac.uk/ena/data/view/J01623 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 6.1.1.14 http://enzyme.expasy.org/EC/6.1.1.14 EchoBASE EB0404 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0404 EcoGene EG10409 http://www.ecogene.org/geneInfo.php?eg_id=EG10409 EnsemblBacteria AAC76584 http://www.ensemblgenomes.org/id/AAC76584 EnsemblBacteria AAC76584 http://www.ensemblgenomes.org/id/AAC76584 EnsemblBacteria BAE77734 http://www.ensemblgenomes.org/id/BAE77734 EnsemblBacteria BAE77734 http://www.ensemblgenomes.org/id/BAE77734 EnsemblBacteria BAE77734 http://www.ensemblgenomes.org/id/BAE77734 EnsemblBacteria b3560 http://www.ensemblgenomes.org/id/b3560 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004820 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004820 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006426 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006426 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GeneID 948079 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948079 HAMAP MF_00254 http://hamap.expasy.org/unirule/MF_00254 HOGENOM HOG000264291 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000264291&db=HOGENOM6 InParanoid P00960 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00960 IntAct P00960 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00960* IntEnz 6.1.1.14 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.1.1.14 InterPro IPR002310 http://www.ebi.ac.uk/interpro/entry/IPR002310 InterPro IPR006194 http://www.ebi.ac.uk/interpro/entry/IPR006194 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW3531 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3531 KEGG_Gene eco:b3560 http://www.genome.jp/dbget-bin/www_bget?eco:b3560 KEGG_Orthology KO:K01878 http://www.genome.jp/dbget-bin/www_bget?KO:K01878 KEGG_Pathway ko00970 http://www.genome.jp/kegg-bin/show_pathway?ko00970 KEGG_Reaction rn:R03654 http://www.genome.jp/dbget-bin/www_bget?rn:R03654 MINT MINT-1225336 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1225336 OMA LGSYYQF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LGSYYQF PRINTS PR01044 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01044 PROSITE PS50861 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50861 PSORT swissprot:SYGA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SYGA_ECOLI PSORT-B swissprot:SYGA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SYGA_ECOLI PSORT2 swissprot:SYGA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SYGA_ECOLI Pfam PF02091 http://pfam.xfam.org/family/PF02091 Phobius swissprot:SYGA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SYGA_ECOLI PhylomeDB P00960 http://phylomedb.org/?seqid=P00960 ProteinModelPortal P00960 http://www.proteinmodelportal.org/query/uniprot/P00960 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6290471 http://www.ncbi.nlm.nih.gov/pubmed/6290471 PubMed 6309809 http://www.ncbi.nlm.nih.gov/pubmed/6309809 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418017 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418017 SMR P00960 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00960 STRING 511145.b3560 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3560&targetmode=cogs STRING COG0752 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0752&targetmode=cogs TIGRFAMs TIGR00388 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00388 UniProtKB SYGA_ECOLI http://www.uniprot.org/uniprot/SYGA_ECOLI UniProtKB-AC P00960 http://www.uniprot.org/uniprot/P00960 charge swissprot:SYGA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SYGA_ECOLI eggNOG COG0752 http://eggnogapi.embl.de/nog_data/html/tree/COG0752 epestfind swissprot:SYGA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SYGA_ECOLI garnier swissprot:SYGA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SYGA_ECOLI helixturnhelix swissprot:SYGA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SYGA_ECOLI hmoment swissprot:SYGA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SYGA_ECOLI iep swissprot:SYGA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SYGA_ECOLI inforesidue swissprot:SYGA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SYGA_ECOLI octanol swissprot:SYGA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SYGA_ECOLI pepcoil swissprot:SYGA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SYGA_ECOLI pepdigest swissprot:SYGA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SYGA_ECOLI pepinfo swissprot:SYGA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SYGA_ECOLI pepnet swissprot:SYGA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SYGA_ECOLI pepstats swissprot:SYGA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SYGA_ECOLI pepwheel swissprot:SYGA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SYGA_ECOLI pepwindow swissprot:SYGA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SYGA_ECOLI sigcleave swissprot:SYGA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SYGA_ECOLI ## Database ID URL or Descriptions # BRENDA 1.1.1.94 2026 # BioGrid 4261265 401 # CATALYTIC ACTIVITY GLPD_ECOLI sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol. # COFACTOR Name=FAD; Xref=ChEBI:CHEBI 57692; # EcoGene EG10394 glpD # FUNCTION GLPD_ECOLI Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses molecular oxygen or nitrate as electron acceptor. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0009331 glycerol-3-phosphate dehydrogenase complex; IDA:EcoCyc. # GO_function GLPD_ECOLI GO 0052590 sn-glycerol-3-phosphate ubiquinone oxidoreductase activity; IDA EcoCyc. # GO_function GLPD_ECOLI GO 0052591 sn-glycerol-3-phosphate ubiquinone-8 oxidoreductase activity; IEA UniProtKB-EC. # GO_function GO:0009055 electron carrier activity; IDA:EcoCyc. # GO_function GO:0071949 FAD binding; IDA:EcoCyc. # GO_process GO:0019563 glycerol catabolic process; IEA:UniProtKB-UniPathway. # GO_process GO:0046168 glycerol-3-phosphate catabolic process; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.50.50.60 -; 1. # IntAct P13035 90 # InterPro IPR000447 G3P_DH_FAD-dep # InterPro IPR006076 FAD-dep_OxRdtase # InterPro IPR023753 FAD/NAD-binding_dom # InterPro IPR031656 DAO_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00564 Glycerophospholipid metabolism # MISCELLANEOUS There are two sn-glycerol-3-phosphate dehydrogenase isozymes in E.coli one is aerobic, the other anaerobic. # Organism GLPD_ECOLI Escherichia coli (strain K12) # PATHWAY Polyol metabolism; glycerol degradation via glycerol kinase pathway; glycerone phosphate from sn-glycerol 3-phosphate (aerobic route) step 1/1. # PATRIC 32122288 VBIEscCol129921_3521 # PDB 2QCU X-ray; 1.75 A; A/B=1-501 # PDB 2R45 X-ray; 2.30 A; A/B=1-501 # PDB 2R46 X-ray; 2.10 A; A/B=1-501 # PDB 2R4E X-ray; 2.10 A; A/B=1-501 # PDB 2R4J X-ray; 1.96 A; A/B=1-501 # PIR A39186 DEECGD # PRINTS PR01001 FADG3PDH # PROSITE PS00977 FAD_G3PDH_1 # PROSITE PS00978 FAD_G3PDH_2 # Pfam PF01266 DAO # Pfam PF16901 DAO_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLPD_ECOLI Aerobic glycerol-3-phosphate dehydrogenase # RefSeq NP_417884 NC_000913.3 # RefSeq WP_000448136 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA23888.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. {ECO 0000305}. # SUBCELLULAR LOCATION GLPD_ECOLI Cytoplasm. # SUPFAM SSF51905 SSF51905; 2 # UniPathway UPA00618 UER00674 # eggNOG COG0578 LUCA # eggNOG ENOG4105C6V Bacteria BLAST swissprot:GLPD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLPD_ECOLI BioCyc ECOL316407:JW3389-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3389-MONOMER BioCyc EcoCyc:AERGLYC3PDEHYDROG-MONOMER http://biocyc.org/getid?id=EcoCyc:AERGLYC3PDEHYDROG-MONOMER BioCyc MetaCyc:AERGLYC3PDEHYDROG-MONOMER http://biocyc.org/getid?id=MetaCyc:AERGLYC3PDEHYDROG-MONOMER COG COG0578 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0578 DIP DIP-9793N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9793N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/16.15.7732 http://dx.doi.org/10.1093/nar/16.15.7732 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.5.3 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.5.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D00425 http://www.ebi.ac.uk/ena/data/view/D00425 EMBL M21277 http://www.ebi.ac.uk/ena/data/view/M21277 EMBL M54940 http://www.ebi.ac.uk/ena/data/view/M54940 EMBL M55989 http://www.ebi.ac.uk/ena/data/view/M55989 EMBL M96795 http://www.ebi.ac.uk/ena/data/view/M96795 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 1.1.5.3 http://enzyme.expasy.org/EC/1.1.5.3 EchoBASE EB0389 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0389 EcoGene EG10394 http://www.ecogene.org/geneInfo.php?eg_id=EG10394 EnsemblBacteria AAC76451 http://www.ensemblgenomes.org/id/AAC76451 EnsemblBacteria AAC76451 http://www.ensemblgenomes.org/id/AAC76451 EnsemblBacteria BAE77866 http://www.ensemblgenomes.org/id/BAE77866 EnsemblBacteria BAE77866 http://www.ensemblgenomes.org/id/BAE77866 EnsemblBacteria BAE77866 http://www.ensemblgenomes.org/id/BAE77866 EnsemblBacteria b3426 http://www.ensemblgenomes.org/id/b3426 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0009331 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009331 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0052590 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052590 GO_function GO:0052591 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052591 GO_function GO:0071949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071949 GO_process GO:0019563 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019563 GO_process GO:0046168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046168 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 GeneID 947934 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947934 HOGENOM HOG000004811 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000004811&db=HOGENOM6 InParanoid P13035 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P13035 IntAct P13035 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P13035* IntEnz 1.1.5.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.5.3 InterPro IPR000447 http://www.ebi.ac.uk/interpro/entry/IPR000447 InterPro IPR006076 http://www.ebi.ac.uk/interpro/entry/IPR006076 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 InterPro IPR031656 http://www.ebi.ac.uk/interpro/entry/IPR031656 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3389 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3389 KEGG_Gene eco:b3426 http://www.genome.jp/dbget-bin/www_bget?eco:b3426 KEGG_Orthology KO:K00111 http://www.genome.jp/dbget-bin/www_bget?KO:K00111 KEGG_Pathway ko00564 http://www.genome.jp/kegg-bin/show_pathway?ko00564 KEGG_Reaction rn:R00848 http://www.genome.jp/dbget-bin/www_bget?rn:R00848 MINT MINT-1248675 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1248675 OMA PWVAKFI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PWVAKFI PDB 2QCU http://www.ebi.ac.uk/pdbe-srv/view/entry/2QCU PDB 2R45 http://www.ebi.ac.uk/pdbe-srv/view/entry/2R45 PDB 2R46 http://www.ebi.ac.uk/pdbe-srv/view/entry/2R46 PDB 2R4E http://www.ebi.ac.uk/pdbe-srv/view/entry/2R4E PDB 2R4J http://www.ebi.ac.uk/pdbe-srv/view/entry/2R4J PDBsum 2QCU http://www.ebi.ac.uk/pdbsum/2QCU PDBsum 2R45 http://www.ebi.ac.uk/pdbsum/2R45 PDBsum 2R46 http://www.ebi.ac.uk/pdbsum/2R46 PDBsum 2R4E http://www.ebi.ac.uk/pdbsum/2R4E PDBsum 2R4J http://www.ebi.ac.uk/pdbsum/2R4J PRINTS PR01001 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01001 PROSITE PS00977 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00977 PROSITE PS00978 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00978 PSORT swissprot:GLPD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLPD_ECOLI PSORT-B swissprot:GLPD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLPD_ECOLI PSORT2 swissprot:GLPD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLPD_ECOLI Pfam PF01266 http://pfam.xfam.org/family/PF01266 Pfam PF16901 http://pfam.xfam.org/family/PF16901 Phobius swissprot:GLPD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLPD_ECOLI PhylomeDB P13035 http://phylomedb.org/?seqid=P13035 ProteinModelPortal P13035 http://www.proteinmodelportal.org/query/uniprot/P13035 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1987111 http://www.ncbi.nlm.nih.gov/pubmed/1987111 PubMed 3045087 http://www.ncbi.nlm.nih.gov/pubmed/3045087 PubMed 3045764 http://www.ncbi.nlm.nih.gov/pubmed/3045764 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417884 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417884 RefSeq WP_000448136 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000448136 SMR P13035 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P13035 STRING 511145.b3426 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3426&targetmode=cogs STRING COG0578 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0578&targetmode=cogs SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 SWISS-2DPAGE P13035 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P13035 UniProtKB GLPD_ECOLI http://www.uniprot.org/uniprot/GLPD_ECOLI UniProtKB-AC P13035 http://www.uniprot.org/uniprot/P13035 charge swissprot:GLPD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLPD_ECOLI eggNOG COG0578 http://eggnogapi.embl.de/nog_data/html/tree/COG0578 eggNOG ENOG4105C6V http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C6V epestfind swissprot:GLPD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLPD_ECOLI garnier swissprot:GLPD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLPD_ECOLI helixturnhelix swissprot:GLPD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLPD_ECOLI hmoment swissprot:GLPD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLPD_ECOLI iep swissprot:GLPD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLPD_ECOLI inforesidue swissprot:GLPD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLPD_ECOLI octanol swissprot:GLPD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLPD_ECOLI pepcoil swissprot:GLPD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLPD_ECOLI pepdigest swissprot:GLPD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLPD_ECOLI pepinfo swissprot:GLPD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLPD_ECOLI pepnet swissprot:GLPD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLPD_ECOLI pepstats swissprot:GLPD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLPD_ECOLI pepwheel swissprot:GLPD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLPD_ECOLI pepwindow swissprot:GLPD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLPD_ECOLI sigcleave swissprot:GLPD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLPD_ECOLI ## Database ID URL or Descriptions # BioGrid 4263075 21 # EcoGene EG13985 ydiZ # GO_function GO:0004521 endoribonuclease activity; IEA:InterPro. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_function GO:0004518 nuclease activity # GOslim_process GO:0006950 response to stress # IntAct P64479 14 # InterPro IPR020499 Uncharacterised_YdiZ # InterPro IPR022597 GhoS # Organism YDIZ_ECOLI Escherichia coli (strain K12) # PATRIC 32118755 VBIEscCol129921_1795 # PIR D64931 D64931 # Pfam PF11080 GhoS # ProDom PD066031 Uncharacterised_YdiZ # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDIZ_ECOLI Uncharacterized protein YdiZ # RefSeq NP_416238 NC_000913.3 # RefSeq WP_000146159 NZ_LN832404.1 # eggNOG ENOG4105P10 Bacteria # eggNOG ENOG4111YV5 LUCA BLAST swissprot:YDIZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDIZ_ECOLI BioCyc ECOL316407:JW1713-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1713-MONOMER BioCyc EcoCyc:G6929-MONOMER http://biocyc.org/getid?id=EcoCyc:G6929-MONOMER DIP DIP-48166N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48166N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3741 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3741 EcoGene EG13985 http://www.ecogene.org/geneInfo.php?eg_id=EG13985 EnsemblBacteria AAC74794 http://www.ensemblgenomes.org/id/AAC74794 EnsemblBacteria AAC74794 http://www.ensemblgenomes.org/id/AAC74794 EnsemblBacteria BAE76509 http://www.ensemblgenomes.org/id/BAE76509 EnsemblBacteria BAE76509 http://www.ensemblgenomes.org/id/BAE76509 EnsemblBacteria BAE76509 http://www.ensemblgenomes.org/id/BAE76509 EnsemblBacteria b1724 http://www.ensemblgenomes.org/id/b1724 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004521 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004521 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 946232 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946232 HOGENOM HOG000121030 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000121030&db=HOGENOM6 IntAct P64479 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P64479* InterPro IPR020499 http://www.ebi.ac.uk/interpro/entry/IPR020499 InterPro IPR022597 http://www.ebi.ac.uk/interpro/entry/IPR022597 KEGG_Gene ecj:JW1713 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1713 KEGG_Gene eco:b1724 http://www.genome.jp/dbget-bin/www_bget?eco:b1724 OMA EVNVEIW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EVNVEIW PSORT swissprot:YDIZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDIZ_ECOLI PSORT-B swissprot:YDIZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDIZ_ECOLI PSORT2 swissprot:YDIZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDIZ_ECOLI Pfam PF11080 http://pfam.xfam.org/family/PF11080 Phobius swissprot:YDIZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDIZ_ECOLI ProteinModelPortal P64479 http://www.proteinmodelportal.org/query/uniprot/P64479 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416238 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416238 RefSeq WP_000146159 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000146159 STRING 511145.b1724 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1724&targetmode=cogs UniProtKB YDIZ_ECOLI http://www.uniprot.org/uniprot/YDIZ_ECOLI UniProtKB-AC P64479 http://www.uniprot.org/uniprot/P64479 charge swissprot:YDIZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDIZ_ECOLI eggNOG ENOG4105P10 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105P10 eggNOG ENOG4111YV5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111YV5 epestfind swissprot:YDIZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDIZ_ECOLI garnier swissprot:YDIZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDIZ_ECOLI helixturnhelix swissprot:YDIZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDIZ_ECOLI hmoment swissprot:YDIZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDIZ_ECOLI iep swissprot:YDIZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDIZ_ECOLI inforesidue swissprot:YDIZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDIZ_ECOLI octanol swissprot:YDIZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDIZ_ECOLI pepcoil swissprot:YDIZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDIZ_ECOLI pepdigest swissprot:YDIZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDIZ_ECOLI pepinfo swissprot:YDIZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDIZ_ECOLI pepnet swissprot:YDIZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDIZ_ECOLI pepstats swissprot:YDIZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDIZ_ECOLI pepwheel swissprot:YDIZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDIZ_ECOLI pepwindow swissprot:YDIZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDIZ_ECOLI sigcleave swissprot:YDIZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDIZ_ECOLI ## Database ID URL or Descriptions # AltName HDFR_ECOLI H-NS-dependent flhDC regulator # BioGrid 4261482 6 # CAUTION Was originally thought to be involved in the expression of the phosphatidylserine synthetase pssA. {ECO:0000305|PubMed 6309791}. # EcoGene EG11449 hdfR # FUNCTION HDFR_ECOLI Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon. {ECO 0000269|PubMed 10913108}. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-HAMAP. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # HAMAP MF_01233 HTH_type_HdfR # IntAct P0A8R9 5 # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR005119 LysR_subst-bd # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR020890 Tscrpt_reg_HTH_HdfR # MISCELLANEOUS HDFR_ECOLI The expression of the hdfR gene is negatively regulated by H-NS. # Organism HDFR_ECOLI Escherichia coli (strain K12) # PATRIC 32123023 VBIEscCol129921_3881 # PIR E65179 E65179 # PRINTS PR00039 HTHLYSR # PROSITE PS50931 HTH_LYSR # Pfam PF00126 HTH_1 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HDFR_ECOLI HTH-type transcriptional regulator HdfR # RefSeq WP_000379245 NZ_LN832404.1 # RefSeq YP_026246 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA24611.1; Type=Frameshift; Positions=75, 79, 81, 86; Evidence={ECO:0000305}; Sequence=AAA67566.1; Type=Frameshift; Positions=81; Note=Produces two separate ORFs.; Evidence={ECO 0000305}; Sequence=AAA67567.1; Type=Frameshift; Positions=81; Note=Produces two separate ORFs.; Evidence={ECO:0000305}; # SIMILARITY Contains 1 HTH lysR-type DNA-binding domain. {ECO 0000305}. # SUPFAM SSF46785 SSF46785 # eggNOG ENOG4105CVI Bacteria # eggNOG ENOG410XP94 LUCA BLAST swissprot:HDFR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HDFR_ECOLI BioCyc ECOL316407:JW5607-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5607-MONOMER BioCyc EcoCyc:EG11449-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11449-MONOMER DIP DIP-48185N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48185N DOI 10.1016/0378-1119(91)90005-V http://dx.doi.org/10.1016/0378-1119(91)90005-V DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.16.4670-4672.2000 http://dx.doi.org/10.1128/JB.182.16.4670-4672.2000 EMBL AF251030 http://www.ebi.ac.uk/ena/data/view/AF251030 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M37337 http://www.ebi.ac.uk/ena/data/view/M37337 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1418 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1418 EcoGene EG11449 http://www.ecogene.org/geneInfo.php?eg_id=EG11449 EnsemblBacteria AAT48206 http://www.ensemblgenomes.org/id/AAT48206 EnsemblBacteria AAT48206 http://www.ensemblgenomes.org/id/AAT48206 EnsemblBacteria BAE77532 http://www.ensemblgenomes.org/id/BAE77532 EnsemblBacteria BAE77532 http://www.ensemblgenomes.org/id/BAE77532 EnsemblBacteria BAE77532 http://www.ensemblgenomes.org/id/BAE77532 EnsemblBacteria b4480 http://www.ensemblgenomes.org/id/b4480 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 2847698 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2847698 HAMAP MF_01233 http://hamap.expasy.org/unirule/MF_01233 HOGENOM HOG000275736 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275736&db=HOGENOM6 InParanoid P0A8R9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8R9 IntAct P0A8R9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8R9* InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR020890 http://www.ebi.ac.uk/interpro/entry/IPR020890 KEGG_Gene ecj:JW5607 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5607 KEGG_Gene eco:b4480 http://www.genome.jp/dbget-bin/www_bget?eco:b4480 OMA ESLMNTW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ESLMNTW PRINTS PR00039 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00039 PROSITE PS50931 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50931 PSORT swissprot:HDFR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HDFR_ECOLI PSORT-B swissprot:HDFR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HDFR_ECOLI PSORT2 swissprot:HDFR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HDFR_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:HDFR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HDFR_ECOLI PhylomeDB P0A8R9 http://phylomedb.org/?seqid=P0A8R9 ProteinModelPortal P0A8R9 http://www.proteinmodelportal.org/query/uniprot/P0A8R9 PubMed 10913108 http://www.ncbi.nlm.nih.gov/pubmed/10913108 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1995430 http://www.ncbi.nlm.nih.gov/pubmed/1995430 PubMed 6309791 http://www.ncbi.nlm.nih.gov/pubmed/6309791 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000379245 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000379245 RefSeq YP_026246 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026246 SMR P0A8R9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8R9 STRING 511145.b4480 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4480&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB HDFR_ECOLI http://www.uniprot.org/uniprot/HDFR_ECOLI UniProtKB-AC P0A8R9 http://www.uniprot.org/uniprot/P0A8R9 charge swissprot:HDFR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HDFR_ECOLI eggNOG ENOG4105CVI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CVI eggNOG ENOG410XP94 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XP94 epestfind swissprot:HDFR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HDFR_ECOLI garnier swissprot:HDFR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HDFR_ECOLI helixturnhelix swissprot:HDFR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HDFR_ECOLI hmoment swissprot:HDFR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HDFR_ECOLI iep swissprot:HDFR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HDFR_ECOLI inforesidue swissprot:HDFR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HDFR_ECOLI octanol swissprot:HDFR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HDFR_ECOLI pepcoil swissprot:HDFR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HDFR_ECOLI pepdigest swissprot:HDFR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HDFR_ECOLI pepinfo swissprot:HDFR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HDFR_ECOLI pepnet swissprot:HDFR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HDFR_ECOLI pepstats swissprot:HDFR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HDFR_ECOLI pepwheel swissprot:HDFR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HDFR_ECOLI pepwindow swissprot:HDFR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HDFR_ECOLI sigcleave swissprot:HDFR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HDFR_ECOLI ## Database ID URL or Descriptions # BioGrid 4259157 10 # EcoGene EG14022 yebT # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # IntAct P76272 6 # InterPro IPR003399 Mce/MlaD # Organism YEBT_ECOLI Escherichia coli (strain K12) # PATRIC 32118989 VBIEscCol129921_1912 # PIR B64945 B64945 # Pfam PF02470 MlaD; 6 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEBT_ECOLI Uncharacterized protein YebT # RefSeq NP_416348 NC_000913.3 # RefSeq WP_001326728 NZ_LN832404.1 # SIMILARITY Belongs to the PqiB family. {ECO 0000305}. # SUBCELLULAR LOCATION YEBT_ECOLI Membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. # eggNOG COG3008 LUCA # eggNOG ENOG4105DY2 Bacteria BLAST swissprot:YEBT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEBT_ECOLI BioCyc ECOL316407:JW1823-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1823-MONOMER BioCyc EcoCyc:G7007-MONOMER http://biocyc.org/getid?id=EcoCyc:G7007-MONOMER DIP DIP-11815N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11815N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3776 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3776 EcoGene EG14022 http://www.ecogene.org/geneInfo.php?eg_id=EG14022 EnsemblBacteria AAC74904 http://www.ensemblgenomes.org/id/AAC74904 EnsemblBacteria AAC74904 http://www.ensemblgenomes.org/id/AAC74904 EnsemblBacteria BAA15647 http://www.ensemblgenomes.org/id/BAA15647 EnsemblBacteria BAA15647 http://www.ensemblgenomes.org/id/BAA15647 EnsemblBacteria BAA15647 http://www.ensemblgenomes.org/id/BAA15647 EnsemblBacteria b1834 http://www.ensemblgenomes.org/id/b1834 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GeneID 946352 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946352 HOGENOM HOG000277695 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000277695&db=HOGENOM6 InParanoid P76272 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76272 IntAct P76272 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76272* InterPro IPR003399 http://www.ebi.ac.uk/interpro/entry/IPR003399 KEGG_Gene ecj:JW1823 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1823 KEGG_Gene eco:b1834 http://www.genome.jp/dbget-bin/www_bget?eco:b1834 OMA RFWNISG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RFWNISG PSORT swissprot:YEBT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEBT_ECOLI PSORT-B swissprot:YEBT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEBT_ECOLI PSORT2 swissprot:YEBT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEBT_ECOLI Pfam PF02470 http://pfam.xfam.org/family/PF02470 Phobius swissprot:YEBT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEBT_ECOLI ProteinModelPortal P76272 http://www.proteinmodelportal.org/query/uniprot/P76272 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416348 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416348 RefSeq WP_001326728 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001326728 STRING 511145.b1834 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1834&targetmode=cogs UniProtKB YEBT_ECOLI http://www.uniprot.org/uniprot/YEBT_ECOLI UniProtKB-AC P76272 http://www.uniprot.org/uniprot/P76272 charge swissprot:YEBT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEBT_ECOLI eggNOG COG3008 http://eggnogapi.embl.de/nog_data/html/tree/COG3008 eggNOG ENOG4105DY2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DY2 epestfind swissprot:YEBT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEBT_ECOLI garnier swissprot:YEBT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEBT_ECOLI helixturnhelix swissprot:YEBT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEBT_ECOLI hmoment swissprot:YEBT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEBT_ECOLI iep swissprot:YEBT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEBT_ECOLI inforesidue swissprot:YEBT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEBT_ECOLI octanol swissprot:YEBT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEBT_ECOLI pepcoil swissprot:YEBT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEBT_ECOLI pepdigest swissprot:YEBT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEBT_ECOLI pepinfo swissprot:YEBT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEBT_ECOLI pepnet swissprot:YEBT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEBT_ECOLI pepstats swissprot:YEBT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEBT_ECOLI pepwheel swissprot:YEBT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEBT_ECOLI pepwindow swissprot:YEBT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEBT_ECOLI sigcleave swissprot:YEBT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEBT_ECOLI ## Database ID URL or Descriptions # AltName RL7_ECOLI L8 # CDD cd00387 Ribosomal_L7_L12 # EcoGene EG10873 rplL # FUNCTION RL7_ECOLI The binding site for several of the GTPase factors involved in protein synthesis (IF-2, EF-Tu, EF-G and RF3). Is thus essential for accurate translation. Deletion of 1 of the L12 dimers from the ribosome (by deleting the binding site on L10) leads to decreased IF-2 association with the 70S ribosome and decreased stimulation of the GTPase activity of EF-G. {ECO 0000269|PubMed 15989950, ECO 0000269|PubMed 22102582}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0022625 cytosolic large ribosomal subunit; IDA:EcoliWiki. # GO_function GO:0003735 structural constituent of ribosome; IEA:InterPro. # GO_process GO:0006412 translation; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_process GO:0006412 translation # Gene3D 3.30.1390.10 -; 1. # HAMAP MF_00368 Ribosomal_L7_L12 # IntAct P0A7K2 127 # InterPro IPR000206 Ribosomal_L7/12 # InterPro IPR008932 Ribosomal_L7/L12_oligo # InterPro IPR013823 Ribosomal_L7/L12_C # InterPro IPR014719 Ribosomal_L7/12_C/ClpS-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=12164; Mass_error=1; Method=Electrospray; Range=2-121; Note=L12, unacetylated.; Evidence={ECO:0000269|PubMed 15923259}; # MASS SPECTROMETRY Mass=12206.7; Method=MALDI; Range=2-121; Note=Non-methylated.; Evidence={ECO:0000269|PubMed 10094780}; # MASS SPECTROMETRY Mass=12223; Mass_error=1; Method=Electrospray; Range=2-121; Note=L7, acetylated Ser-2.; Evidence={ECO:0000269|PubMed 15923259}; # MASS SPECTROMETRY Mass=66643; Mass_error=13; Method=Electrospray; Range=2-121; Note=Isolated L10(L12)4.; Evidence={ECO:0000269|PubMed 15923259}; # MISCELLANEOUS Ribosomal protein L8 appears to be an aggregate of ribosomal proteins L7/L12 and L10. {ECO:0000269|PubMed 773698}. # Organism RL7_ECOLI Escherichia coli (strain K12) # PATRIC 32123493 VBIEscCol129921_4099 # PDB 1CTF X-ray; 1.70 A; A=48-121 # PDB 1RQS NMR; -; A=48-121 # PDB 1RQT NMR; -; A/B=2-38 # PDB 1RQU NMR; -; A/B=2-121 # PDB 1RQV NMR; -; A/B=2-121 # PDB 2BCW EM; 11.20 A; B=54-121 # PDB 3J7Z EM; 3.90 A; 6=1-121 # PDB 4UY8 EM; 3.80 A; 6=2-31 # PDB 4V4V EM; 15.00 A; B3/B5=3-121 # PDB 4V4W EM; 15.00 A; B3/B5=3-121 # PDB 4V5M EM; 7.80 A; BL=1-121 # PDB 4V5N EM; 7.60 A; BL=1-121 # PDB 4V7B EM; 6.80 A; B6=1-121 # PDB 4V7D EM; 7.60 A; AL=2-121 # PDB 4V85 X-ray; 3.20 A; J/K/L/M=1-121 # PDB 4V89 X-ray; 3.70 A; BJ/BK/BL/BM=1-121 # PDB 4V9O X-ray; 2.90 A; A6=1-121 # PDB 5KCS EM; 3.90 A; 1L=1-121 # PIR S12575 R5EC7 # PTM RL7_ECOLI Acetylation of Ser-2 converts L12 to L7. # PTM RL7_ECOLI Lys-82 was found to be 50% monomethylated. {ECO 0000269|PubMed 4573678}. # Pfam PF00542 Ribosomal_L12 # Pfam PF16320 Ribosomal_L12_N # ProDom PD001326 Ribosomal_L7/L12_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 50S ribosomal protein L7/L12 {ECO:0000255|HAMAP-Rule MF_00368} # RefSeq NP_418413 NC_000913.3 # RefSeq WP_000028878 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein L7/L12P family. {ECO:0000255|HAMAP-Rule MF_00368}. # SUBUNIT RL7_ECOLI Homodimer. Part of the 50S ribosomal subunit; present in 4 copies per ribosome. L7/L12 forms dimers with an elongated shape. Two dimers associate with a copy of L10 to form part of the ribosomal stalk (called L8). The ribosomal stalk helps the ribosome interact with GTP-bound translation factors. Forms a pentameric L10(L12)2(L12)2 complex, where L10 forms an elongated spine to which 2 L12 dimers bind in a sequential fashion. {ECO 0000269|PubMed 15923259, ECO 0000269|PubMed 15989950}. # SUPFAM SSF48300 SSF48300 # SUPFAM SSF54736 SSF54736 # TIGRFAMs TIGR00855 L12 # eggNOG COG0222 LUCA # eggNOG ENOG4105KBC Bacteria BLAST swissprot:RL7_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RL7_ECOLI BioCyc ECOL316407:JW3949-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3949-MONOMER BioCyc EcoCyc:EG10873-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10873-MONOMER BioCyc MetaCyc:EG10873-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10873-MONOMER COG COG0222 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0222 DIP DIP-36009N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36009N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1006/jmbi.1998.1726 http://dx.doi.org/10.1006/jmbi.1998.1726 DOI 10.1016/0014-5793(76)80267-0 http://dx.doi.org/10.1016/0014-5793(76)80267-0 DOI 10.1016/0014-5793(95)01531-0 http://dx.doi.org/10.1016/0014-5793(95)01531-0 DOI 10.1016/0022-2836(87)90183-5 http://dx.doi.org/10.1016/0022-2836(87)90183-5 DOI 10.1016/S0014-5793(98)00121-5 http://dx.doi.org/10.1016/S0014-5793(98)00121-5 DOI 10.1016/j.cell.2005.04.015 http://dx.doi.org/10.1016/j.cell.2005.04.015 DOI 10.1016/j.celrep.2014.09.011 http://dx.doi.org/10.1016/j.celrep.2014.09.011 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0502193102 http://dx.doi.org/10.1073/pnas.0502193102 DOI 10.1073/pnas.76.4.1697 http://dx.doi.org/10.1073/pnas.76.4.1697 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1093/nar/gkr1031 http://dx.doi.org/10.1093/nar/gkr1031 DOI 10.1111/j.1432-1033.1973.tb02740.x http://dx.doi.org/10.1111/j.1432-1033.1973.tb02740.x DOI 10.1111/j.1574-6968.1998.tb13343.x http://dx.doi.org/10.1111/j.1574-6968.1998.tb13343.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M38301 http://www.ebi.ac.uk/ena/data/view/M38301 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00339 http://www.ebi.ac.uk/ena/data/view/V00339 EchoBASE EB0866 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0866 EcoGene EG10873 http://www.ecogene.org/geneInfo.php?eg_id=EG10873 EnsemblBacteria AAC76960 http://www.ensemblgenomes.org/id/AAC76960 EnsemblBacteria AAC76960 http://www.ensemblgenomes.org/id/AAC76960 EnsemblBacteria BAE77334 http://www.ensemblgenomes.org/id/BAE77334 EnsemblBacteria BAE77334 http://www.ensemblgenomes.org/id/BAE77334 EnsemblBacteria BAE77334 http://www.ensemblgenomes.org/id/BAE77334 EnsemblBacteria b3986 http://www.ensemblgenomes.org/id/b3986 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0022625 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022625 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 Gene3D 3.30.1390.10 http://www.cathdb.info/version/latest/superfamily/3.30.1390.10 GeneID 948489 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948489 HAMAP MF_00368 http://hamap.expasy.org/unirule/MF_00368 HOGENOM HOG000248813 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000248813&db=HOGENOM6 InParanoid P0A7K2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7K2 IntAct P0A7K2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7K2* InterPro IPR000206 http://www.ebi.ac.uk/interpro/entry/IPR000206 InterPro IPR008932 http://www.ebi.ac.uk/interpro/entry/IPR008932 InterPro IPR013823 http://www.ebi.ac.uk/interpro/entry/IPR013823 InterPro IPR014719 http://www.ebi.ac.uk/interpro/entry/IPR014719 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW3949 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3949 KEGG_Gene eco:b3986 http://www.genome.jp/dbget-bin/www_bget?eco:b3986 KEGG_Orthology KO:K02935 http://www.genome.jp/dbget-bin/www_bget?KO:K02935 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 MINT MINT-1277405 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1277405 OMA GLKETWG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GLKETWG PDB 1CTF http://www.ebi.ac.uk/pdbe-srv/view/entry/1CTF PDB 1RQS http://www.ebi.ac.uk/pdbe-srv/view/entry/1RQS PDB 1RQT http://www.ebi.ac.uk/pdbe-srv/view/entry/1RQT PDB 1RQU http://www.ebi.ac.uk/pdbe-srv/view/entry/1RQU PDB 1RQV http://www.ebi.ac.uk/pdbe-srv/view/entry/1RQV PDB 2BCW http://www.ebi.ac.uk/pdbe-srv/view/entry/2BCW PDB 3J7Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J7Z PDB 4UY8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4UY8 PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V5M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5M PDB 4V5N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5N PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDBsum 1CTF http://www.ebi.ac.uk/pdbsum/1CTF PDBsum 1RQS http://www.ebi.ac.uk/pdbsum/1RQS PDBsum 1RQT http://www.ebi.ac.uk/pdbsum/1RQT PDBsum 1RQU http://www.ebi.ac.uk/pdbsum/1RQU PDBsum 1RQV http://www.ebi.ac.uk/pdbsum/1RQV PDBsum 2BCW http://www.ebi.ac.uk/pdbsum/2BCW PDBsum 3J7Z http://www.ebi.ac.uk/pdbsum/3J7Z PDBsum 4UY8 http://www.ebi.ac.uk/pdbsum/4UY8 PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V5M http://www.ebi.ac.uk/pdbsum/4V5M PDBsum 4V5N http://www.ebi.ac.uk/pdbsum/4V5N PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PSORT swissprot:RL7_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RL7_ECOLI PSORT-B swissprot:RL7_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RL7_ECOLI PSORT2 swissprot:RL7_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RL7_ECOLI Pfam PF00542 http://pfam.xfam.org/family/PF00542 Pfam PF16320 http://pfam.xfam.org/family/PF16320 Phobius swissprot:RL7_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RL7_ECOLI PhylomeDB P0A7K2 http://phylomedb.org/?seqid=P0A7K2 ProteinModelPortal P0A7K2 http://www.proteinmodelportal.org/query/uniprot/P0A7K2 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 15923259 http://www.ncbi.nlm.nih.gov/pubmed/15923259 PubMed 15989950 http://www.ncbi.nlm.nih.gov/pubmed/15989950 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22102582 http://www.ncbi.nlm.nih.gov/pubmed/22102582 PubMed 25310980 http://www.ncbi.nlm.nih.gov/pubmed/25310980 PubMed 3309338 http://www.ncbi.nlm.nih.gov/pubmed/3309338 PubMed 377281 http://www.ncbi.nlm.nih.gov/pubmed/377281 PubMed 4573678 http://www.ncbi.nlm.nih.gov/pubmed/4573678 PubMed 773698 http://www.ncbi.nlm.nih.gov/pubmed/773698 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 8603708 http://www.ncbi.nlm.nih.gov/pubmed/8603708 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9515737 http://www.ncbi.nlm.nih.gov/pubmed/9515737 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 PubMed 9868784 http://www.ncbi.nlm.nih.gov/pubmed/9868784 RefSeq NP_418413 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418413 RefSeq WP_000028878 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000028878 SMR P0A7K2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7K2 STRING 511145.b3986 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3986&targetmode=cogs STRING COG0222 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0222&targetmode=cogs SUPFAM SSF48300 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48300 SUPFAM SSF54736 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54736 SWISS-2DPAGE P0A7K2 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A7K2 TIGRFAMs TIGR00855 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00855 UniProtKB RL7_ECOLI http://www.uniprot.org/uniprot/RL7_ECOLI UniProtKB-AC P0A7K2 http://www.uniprot.org/uniprot/P0A7K2 charge swissprot:RL7_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RL7_ECOLI eggNOG COG0222 http://eggnogapi.embl.de/nog_data/html/tree/COG0222 eggNOG ENOG4105KBC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KBC epestfind swissprot:RL7_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RL7_ECOLI garnier swissprot:RL7_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RL7_ECOLI helixturnhelix swissprot:RL7_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RL7_ECOLI hmoment swissprot:RL7_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RL7_ECOLI iep swissprot:RL7_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RL7_ECOLI inforesidue swissprot:RL7_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RL7_ECOLI octanol swissprot:RL7_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RL7_ECOLI pepcoil swissprot:RL7_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RL7_ECOLI pepdigest swissprot:RL7_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RL7_ECOLI pepinfo swissprot:RL7_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RL7_ECOLI pepnet swissprot:RL7_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RL7_ECOLI pepstats swissprot:RL7_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RL7_ECOLI pepwheel swissprot:RL7_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RL7_ECOLI pepwindow swissprot:RL7_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RL7_ECOLI sigcleave swissprot:RL7_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RL7_ECOLI ## Database ID URL or Descriptions # BioGrid 4260766 345 # EcoGene EG11561 caiT # FUNCTION CAIT_ECOLI Catalyzes the exchange of L-carnitine for gamma- butyrobetaine and related betaines. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function CAIT_ECOLI GO 0044667 (R)-carnitine 4-(trimethylammonio)butanoate antiporter activity; IEA InterPro. # GO_function GO:0015226 carnitine transmembrane transporter activity; IDA:EcoCyc. # GO_process GO:0009437 carnitine metabolic process; IEA:UniProtKB-UniPathway. # GO_process GO:0015879 carnitine transport; IDA:EcoCyc. # GO_process GO:1900751 4-(trimethylammonio)butanoate transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # HAMAP MF_01049 CaiT # InterPro IPR000060 BCCT_transptr # InterPro IPR018093 BCCT_CS # InterPro IPR023449 BCCT_transptr_CaiT # Organism CAIT_ECOLI Escherichia coli (strain K12) # PATHWAY Amine and polyamine metabolism; carnitine metabolism. {ECO:0000255|HAMAP-Rule MF_01049}. # PATRIC 32115175 VBIEscCol129921_0039 # PDB 2WSX X-ray; 3.50 A; A/B/C=1-504 # PDB 3HFX X-ray; 3.15 A; A=1-504 # PIR H64724 H64724 # PROSITE PS01303 BCCT # Pfam PF02028 BCCT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName L-carnitine/gamma-butyrobetaine antiporter {ECO:0000255|HAMAP-Rule MF_01049} # RefSeq NP_414582 NC_000913.3 # RefSeq WP_000787103 NZ_LN832404.1 # SIMILARITY Belongs to the BCCT transporter (TC 2.A.15) family. CaiT subfamily. {ECO:0000255|HAMAP-Rule MF_01049}. # SUBCELLULAR LOCATION CAIT_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01049, ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255|HAMAP-Rule MF_01049, ECO 0000269|PubMed 15919996}. # TCDB 2.A.15.2 the betaine/carnitine/choline transporter (bcct) family # TIGRFAMs TIGR00842 bcct # eggNOG COG1292 LUCA # eggNOG ENOG4105C94 Bacteria BLAST swissprot:CAIT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CAIT_ECOLI BioCyc ECOL316407:JW0039-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0039-MONOMER BioCyc EcoCyc:CAIT-MONOMER http://biocyc.org/getid?id=EcoCyc:CAIT-MONOMER BioCyc MetaCyc:CAIT-MONOMER http://biocyc.org/getid?id=MetaCyc:CAIT-MONOMER COG COG1292 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1292 DIP DIP-9247N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9247N DOI 10.1007/s00239-002-2423-0 http://dx.doi.org/10.1007/s00239-002-2423-0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M206319200 http://dx.doi.org/10.1074/jbc.M206319200 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1111/j.1365-2958.1994.tb00470.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb00470.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL AY625104 http://www.ebi.ac.uk/ena/data/view/AY625104 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X73904 http://www.ebi.ac.uk/ena/data/view/X73904 EchoBASE EB1522 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1522 EcoGene EG11561 http://www.ecogene.org/geneInfo.php?eg_id=EG11561 EnsemblBacteria AAC73151 http://www.ensemblgenomes.org/id/AAC73151 EnsemblBacteria AAC73151 http://www.ensemblgenomes.org/id/AAC73151 EnsemblBacteria BAB96609 http://www.ensemblgenomes.org/id/BAB96609 EnsemblBacteria BAB96609 http://www.ensemblgenomes.org/id/BAB96609 EnsemblBacteria BAB96609 http://www.ensemblgenomes.org/id/BAB96609 EnsemblBacteria b0040 http://www.ensemblgenomes.org/id/b0040 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015226 GO_function GO:0044667 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044667 GO_process GO:0009437 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009437 GO_process GO:0015879 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015879 GO_process GO:1900751 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1900751 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 944765 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944765 HAMAP MF_01049 http://hamap.expasy.org/unirule/MF_01049 HOGENOM HOG000053240 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000053240&db=HOGENOM6 InParanoid P31553 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31553 InterPro IPR000060 http://www.ebi.ac.uk/interpro/entry/IPR000060 InterPro IPR018093 http://www.ebi.ac.uk/interpro/entry/IPR018093 InterPro IPR023449 http://www.ebi.ac.uk/interpro/entry/IPR023449 KEGG_Gene ecj:JW0039 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0039 KEGG_Gene eco:b0040 http://www.genome.jp/dbget-bin/www_bget?eco:b0040 KEGG_Orthology KO:K05245 http://www.genome.jp/dbget-bin/www_bget?KO:K05245 OMA CWIVLNA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CWIVLNA PDB 2WSX http://www.ebi.ac.uk/pdbe-srv/view/entry/2WSX PDB 3HFX http://www.ebi.ac.uk/pdbe-srv/view/entry/3HFX PDBsum 2WSX http://www.ebi.ac.uk/pdbsum/2WSX PDBsum 3HFX http://www.ebi.ac.uk/pdbsum/3HFX PROSITE PS01303 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01303 PSORT swissprot:CAIT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CAIT_ECOLI PSORT-B swissprot:CAIT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CAIT_ECOLI PSORT2 swissprot:CAIT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CAIT_ECOLI Pfam PF02028 http://pfam.xfam.org/family/PF02028 Phobius swissprot:CAIT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CAIT_ECOLI PhylomeDB P31553 http://phylomedb.org/?seqid=P31553 ProteinModelPortal P31553 http://www.proteinmodelportal.org/query/uniprot/P31553 PubMed 12163501 http://www.ncbi.nlm.nih.gov/pubmed/12163501 PubMed 12664169 http://www.ncbi.nlm.nih.gov/pubmed/12664169 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7815937 http://www.ncbi.nlm.nih.gov/pubmed/7815937 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414582 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414582 RefSeq WP_000787103 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000787103 SMR P31553 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31553 STRING 511145.b0040 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0040&targetmode=cogs STRING COG1292 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1292&targetmode=cogs TCDB 2.A.15.2 http://www.tcdb.org/search/result.php?tc=2.A.15.2 TIGRFAMs TIGR00842 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00842 UniProtKB CAIT_ECOLI http://www.uniprot.org/uniprot/CAIT_ECOLI UniProtKB-AC P31553 http://www.uniprot.org/uniprot/P31553 charge swissprot:CAIT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CAIT_ECOLI eggNOG COG1292 http://eggnogapi.embl.de/nog_data/html/tree/COG1292 eggNOG ENOG4105C94 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C94 epestfind swissprot:CAIT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CAIT_ECOLI garnier swissprot:CAIT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CAIT_ECOLI helixturnhelix swissprot:CAIT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CAIT_ECOLI hmoment swissprot:CAIT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CAIT_ECOLI iep swissprot:CAIT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CAIT_ECOLI inforesidue swissprot:CAIT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CAIT_ECOLI octanol swissprot:CAIT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CAIT_ECOLI pepcoil swissprot:CAIT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CAIT_ECOLI pepdigest swissprot:CAIT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CAIT_ECOLI pepinfo swissprot:CAIT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CAIT_ECOLI pepnet swissprot:CAIT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CAIT_ECOLI pepstats swissprot:CAIT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CAIT_ECOLI pepwheel swissprot:CAIT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CAIT_ECOLI pepwindow swissprot:CAIT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CAIT_ECOLI sigcleave swissprot:CAIT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CAIT_ECOLI ## Database ID URL or Descriptions # AltName GCH1_ECOLI GTP cyclohydrolase I # BRENDA 3.5.4.16 2026 # BioGrid 4263524 298 # CATALYTIC ACTIVITY GCH1_ECOLI GTP + H(2)O = formate + 2-amino-4-hydroxy-6- (erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. # ENZYME REGULATION GCH1_ECOLI Allosteric enzyme. Activity is modulated by K(+), divalent cations, UTP, and tetrahydrobiopterin. Tetrahydrobiopterin is an inhibitor of this enzyme. # EcoGene EG11375 folE # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0043234 protein complex; IDA:EcoliWiki. # GO_function GO:0003934 GTP cyclohydrolase I activity; IDA:EcoCyc. # GO_function GO:0005525 GTP binding; IDA:EcoliWiki. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_process GO:0006729 tetrahydrobiopterin biosynthetic process; IBA:GO_Central. # GO_process GO:0006730 one-carbon metabolic process; IEA:UniProtKB-HAMAP. # GO_process GO:0008616 queuosine biosynthetic process; IMP:EcoCyc. # GO_process GO:0035998 7,8-dihydroneopterin 3'-triphosphate biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0046654 tetrahydrofolate biosynthetic process; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # HAMAP MF_00223 FolE # InterPro IPR001474 GTP_CycHdrlase_I # InterPro IPR018234 GTP_CycHdrlase_I_CS # InterPro IPR020602 GTP_CycHdrlase_I_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00790 Folate biosynthesis # Organism GCH1_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11109 PTHR11109 # PATHWAY Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP step 1/1. # PATRIC 32119653 VBIEscCol129921_2237 # PDB 1A8R X-ray; 2.10 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O=2-222 # PDB 1A9C X-ray; 2.90 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O=2-222 # PDB 1FBX X-ray; 2.80 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O=2-222 # PDB 1GTP X-ray; 3.00 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T=2-222 # PDB 1N3R X-ray; 2.80 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O=2-222 # PDB 1N3S X-ray; 2.55 A; A/B/C/D/E/F/G/H/I/J=2-222 # PDB 1N3T X-ray; 3.20 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O=2-222 # PIR H64983 H64983 # PIR S29895 S29895 # PROSITE PS00859 GTP_CYCLOHYDROL_1_1 # PROSITE PS00860 GTP_CYCLOHYDROL_1_2 # Pfam PF01227 GTP_cyclohydroI # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GCH1_ECOLI GTP cyclohydrolase 1 # RefSeq NP_416658 NC_000913.3 # RefSeq WP_001139613 NZ_LN832404.1 # SIMILARITY Belongs to the GTP cyclohydrolase I family. {ECO 0000305}. # SUBUNIT GCH1_ECOLI Toroid-shaped homodecamer, composed of two pentamers of five dimers. {ECO 0000269|PubMed 11087827, ECO 0000269|PubMed 12297008}. # TIGRFAMs TIGR00063 folE # UniPathway UPA00848 UER00151 # eggNOG COG0302 LUCA # eggNOG ENOG4105EUJ Bacteria BLAST swissprot:GCH1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GCH1_ECOLI BioCyc ECOL316407:JW2140-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2140-MONOMER BioCyc EcoCyc:GTP-CYCLOHYDRO-I-MONOMER http://biocyc.org/getid?id=EcoCyc:GTP-CYCLOHYDRO-I-MONOMER BioCyc MetaCyc:GTP-CYCLOHYDRO-I-MONOMER http://biocyc.org/getid?id=MetaCyc:GTP-CYCLOHYDRO-I-MONOMER COG COG0302 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0302 DIP DIP-9676N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9676N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1016/S0022-2836(02)01303-7 http://dx.doi.org/10.1016/S0022-2836(02)01303-7 DOI 10.1016/S0969-2126(01)00179-4 http://dx.doi.org/10.1016/S0969-2126(01)00179-4 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.240463497 http://dx.doi.org/10.1073/pnas.240463497 DOI 10.1111/j.1432-1033.1992.tb17455.x http://dx.doi.org/10.1111/j.1432-1033.1992.tb17455.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.5483/BMBRep.2002.35.3.255 http://dx.doi.org/10.5483/BMBRep.2002.35.3.255 EC_number EC:3.5.4.16 http://www.genome.jp/dbget-bin/www_bget?EC:3.5.4.16 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X63910 http://www.ebi.ac.uk/ena/data/view/X63910 ENZYME 3.5.4.16 http://enzyme.expasy.org/EC/3.5.4.16 EchoBASE EB1349 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1349 EcoGene EG11375 http://www.ecogene.org/geneInfo.php?eg_id=EG11375 EnsemblBacteria AAC75214 http://www.ensemblgenomes.org/id/AAC75214 EnsemblBacteria AAC75214 http://www.ensemblgenomes.org/id/AAC75214 EnsemblBacteria BAE76630 http://www.ensemblgenomes.org/id/BAE76630 EnsemblBacteria BAE76630 http://www.ensemblgenomes.org/id/BAE76630 EnsemblBacteria BAE76630 http://www.ensemblgenomes.org/id/BAE76630 EnsemblBacteria b2153 http://www.ensemblgenomes.org/id/b2153 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GO_function GO:0003934 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003934 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_process GO:0006729 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006729 GO_process GO:0006730 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006730 GO_process GO:0008616 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008616 GO_process GO:0035998 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035998 GO_process GO:0046654 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046654 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GeneID 949040 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949040 HAMAP MF_00223 http://hamap.expasy.org/unirule/MF_00223 HOGENOM HOG000221222 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000221222&db=HOGENOM6 InParanoid P0A6T5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6T5 IntAct P0A6T5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6T5* IntEnz 3.5.4.16 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.4.16 InterPro IPR001474 http://www.ebi.ac.uk/interpro/entry/IPR001474 InterPro IPR018234 http://www.ebi.ac.uk/interpro/entry/IPR018234 InterPro IPR020602 http://www.ebi.ac.uk/interpro/entry/IPR020602 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2140 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2140 KEGG_Gene eco:b2153 http://www.genome.jp/dbget-bin/www_bget?eco:b2153 KEGG_Orthology KO:K01495 http://www.genome.jp/dbget-bin/www_bget?KO:K01495 KEGG_Pathway ko00790 http://www.genome.jp/kegg-bin/show_pathway?ko00790 KEGG_Reaction rn:R00428 http://www.genome.jp/dbget-bin/www_bget?rn:R00428 KEGG_Reaction rn:R04639 http://www.genome.jp/dbget-bin/www_bget?rn:R04639 KEGG_Reaction rn:R05046 http://www.genome.jp/dbget-bin/www_bget?rn:R05046 KEGG_Reaction rn:R05048 http://www.genome.jp/dbget-bin/www_bget?rn:R05048 MINT MINT-6732927 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-6732927 OMA ISGHMTE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ISGHMTE PANTHER PTHR11109 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11109 PDB 1A8R http://www.ebi.ac.uk/pdbe-srv/view/entry/1A8R PDB 1A9C http://www.ebi.ac.uk/pdbe-srv/view/entry/1A9C PDB 1FBX http://www.ebi.ac.uk/pdbe-srv/view/entry/1FBX PDB 1GTP http://www.ebi.ac.uk/pdbe-srv/view/entry/1GTP PDB 1N3R http://www.ebi.ac.uk/pdbe-srv/view/entry/1N3R PDB 1N3S http://www.ebi.ac.uk/pdbe-srv/view/entry/1N3S PDB 1N3T http://www.ebi.ac.uk/pdbe-srv/view/entry/1N3T PDBsum 1A8R http://www.ebi.ac.uk/pdbsum/1A8R PDBsum 1A9C http://www.ebi.ac.uk/pdbsum/1A9C PDBsum 1FBX http://www.ebi.ac.uk/pdbsum/1FBX PDBsum 1GTP http://www.ebi.ac.uk/pdbsum/1GTP PDBsum 1N3R http://www.ebi.ac.uk/pdbsum/1N3R PDBsum 1N3S http://www.ebi.ac.uk/pdbsum/1N3S PDBsum 1N3T http://www.ebi.ac.uk/pdbsum/1N3T PROSITE PS00859 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00859 PROSITE PS00860 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00860 PSORT swissprot:GCH1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GCH1_ECOLI PSORT-B swissprot:GCH1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GCH1_ECOLI PSORT2 swissprot:GCH1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GCH1_ECOLI Pfam PF01227 http://pfam.xfam.org/family/PF01227 Phobius swissprot:GCH1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GCH1_ECOLI PhylomeDB P0A6T5 http://phylomedb.org/?seqid=P0A6T5 ProteinModelPortal P0A6T5 http://www.proteinmodelportal.org/query/uniprot/P0A6T5 PubMed 11087827 http://www.ncbi.nlm.nih.gov/pubmed/11087827 PubMed 12297008 http://www.ncbi.nlm.nih.gov/pubmed/12297008 PubMed 12559918 http://www.ncbi.nlm.nih.gov/pubmed/12559918 PubMed 1459137 http://www.ncbi.nlm.nih.gov/pubmed/1459137 PubMed 1665332 http://www.ncbi.nlm.nih.gov/pubmed/1665332 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7663943 http://www.ncbi.nlm.nih.gov/pubmed/7663943 PubMed 8304099 http://www.ncbi.nlm.nih.gov/pubmed/8304099 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_416658 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416658 RefSeq WP_001139613 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001139613 SMR P0A6T5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6T5 STRING 511145.b2153 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2153&targetmode=cogs STRING COG0302 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0302&targetmode=cogs TIGRFAMs TIGR00063 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00063 UniProtKB GCH1_ECOLI http://www.uniprot.org/uniprot/GCH1_ECOLI UniProtKB-AC P0A6T5 http://www.uniprot.org/uniprot/P0A6T5 charge swissprot:GCH1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GCH1_ECOLI eggNOG COG0302 http://eggnogapi.embl.de/nog_data/html/tree/COG0302 eggNOG ENOG4105EUJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EUJ epestfind swissprot:GCH1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GCH1_ECOLI garnier swissprot:GCH1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GCH1_ECOLI helixturnhelix swissprot:GCH1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GCH1_ECOLI hmoment swissprot:GCH1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GCH1_ECOLI iep swissprot:GCH1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GCH1_ECOLI inforesidue swissprot:GCH1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GCH1_ECOLI octanol swissprot:GCH1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GCH1_ECOLI pepcoil swissprot:GCH1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GCH1_ECOLI pepdigest swissprot:GCH1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GCH1_ECOLI pepinfo swissprot:GCH1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GCH1_ECOLI pepnet swissprot:GCH1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GCH1_ECOLI pepstats swissprot:GCH1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GCH1_ECOLI pepwheel swissprot:GCH1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GCH1_ECOLI pepwindow swissprot:GCH1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GCH1_ECOLI sigcleave swissprot:GCH1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GCH1_ECOLI ## Database ID URL or Descriptions # BioGrid 4261701 10 # CDD cd06261 TM_PBP2 # EcoGene EG10555 malF # FUNCTION MALF_ECOLI Part of the binding-protein-dependent transport system for maltose; probably responsible for the translocation of the substrate across the membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IDA:EcoCyc. # GO_component GO:0055052 ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing; IBA:GO_Central. # GO_component GO:1990060 maltose transport complex; IDA:EcoCyc. # GO_function GO:0015423 maltose-transporting ATPase activity; IDA:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0015768 maltose transport; IDA:EcoCyc. # GO_process GO:0042956 maltodextrin transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0006950 response to stress # Gene3D 1.10.3720.10 -; 1. # INTERACTION MALF_ECOLI P0AEX9 malE; NbExp=2; IntAct=EBI-1118919, EBI-369910; # IntAct P02916 5 # InterPro IPR000515 MetI-like # InterPro IPR029345 MalF_P2 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00194 Maltose/maltodextrin transport system # KEGG_Brite ko02000 M00197 Putative fructooligosaccharide transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # MISCELLANEOUS MALF_ECOLI When MalF EAA loop mutations are made concomitantly with MalG EAA loop mutations, a complete loss of transport and complex formation is observed, except for the Gly-407. This suggests that the MalF-MalG interaction may be important for the proper assembly and also for the correct function of the transporter. # Organism MALF_ECOLI Escherichia coli (strain K12) # PATRIC 32123599 VBIEscCol129921_4148 # PDB 2R6G X-ray; 2.80 A; F=1-514 # PDB 3FH6 X-ray; 4.50 A; F/H=36-514 # PDB 3PUV X-ray; 2.40 A; F=1-514 # PDB 3PUW X-ray; 2.30 A; F=1-514 # PDB 3PUX X-ray; 2.30 A; F=1-514 # PDB 3PUY X-ray; 3.10 A; F=1-514 # PDB 3PUZ X-ray; 2.90 A; F=1-514 # PDB 3PV0 X-ray; 3.10 A; F=1-514 # PDB 3RLF X-ray; 2.20 A; F=1-514 # PDB 4JBW X-ray; 3.91 A; F/H=1-514 # PDB 4KHZ X-ray; 2.90 A; F=1-514 # PDB 4KI0 X-ray; 2.38 A; F=1-514 # PIR A03414 MMECMF # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Pfam PF14785 MalF_P2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MALF_ECOLI Maltose transport system permease protein MalF # RefSeq NP_418457 NC_000913.3 # RefSeq WP_001297290 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION MALF_ECOLI Cell inner membrane {ECO 0000269|PubMed 18456666}; Multi-pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00441, ECO 0000269|PubMed 18456666}; Periplasmic side {ECO 0000269|PubMed 18456666}. Note=A substantial portion of it protrudes into the periplasmic space; inserts in an SRP- and Sec- dependent, YidC-independent fashion into the membrane. # SUBUNIT MALF_ECOLI The complex is composed of two ATP-binding proteins (MalK), two transmembrane proteins (MalG and MalF) and a solute- binding protein (MalE). Protein stability and stable complex formation require YidC. {ECO 0000269|PubMed 10809785, ECO 0000269|PubMed 18456666}. # SUPFAM SSF161098 SSF161098 # TCDB 3.A.1.1 the atp-binding cassette (abc) superfamily # eggNOG COG1175 LUCA # eggNOG ENOG4105D56 Bacteria BLAST swissprot:MALF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MALF_ECOLI BioCyc ECOL316407:JW3993-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3993-MONOMER BioCyc EcoCyc:MALF-MONOMER http://biocyc.org/getid?id=EcoCyc:MALF-MONOMER BioCyc MetaCyc:MALF-MONOMER http://biocyc.org/getid?id=MetaCyc:MALF-MONOMER COG COG1175 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1175 DIP DIP-10142N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10142N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.87.19.7574 http://dx.doi.org/10.1073/pnas.87.19.7574 DOI 10.1074/jbc.275.20.15526 http://dx.doi.org/10.1074/jbc.275.20.15526 DOI 10.1074/jbc.M801481200 http://dx.doi.org/10.1074/jbc.M801481200 DOI 10.1093/emboj/16.11.3066 http://dx.doi.org/10.1093/emboj/16.11.3066 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01648 http://www.ebi.ac.uk/ena/data/view/J01648 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X02871 http://www.ebi.ac.uk/ena/data/view/X02871 EchoBASE EB0550 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0550 EcoGene EG10555 http://www.ecogene.org/geneInfo.php?eg_id=EG10555 EnsemblBacteria AAC77003 http://www.ensemblgenomes.org/id/AAC77003 EnsemblBacteria AAC77003 http://www.ensemblgenomes.org/id/AAC77003 EnsemblBacteria BAE78035 http://www.ensemblgenomes.org/id/BAE78035 EnsemblBacteria BAE78035 http://www.ensemblgenomes.org/id/BAE78035 EnsemblBacteria BAE78035 http://www.ensemblgenomes.org/id/BAE78035 EnsemblBacteria b4033 http://www.ensemblgenomes.org/id/b4033 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_component GO:0055052 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055052 GO_component GO:1990060 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990060 GO_function GO:0015423 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015423 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0015768 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015768 GO_process GO:0042956 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042956 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 948532 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948532 HOGENOM HOG000239267 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000239267&db=HOGENOM6 InParanoid P02916 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P02916 IntAct P02916 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P02916* InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 InterPro IPR029345 http://www.ebi.ac.uk/interpro/entry/IPR029345 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3993 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3993 KEGG_Gene eco:b4033 http://www.genome.jp/dbget-bin/www_bget?eco:b4033 KEGG_Orthology KO:K10109 http://www.genome.jp/dbget-bin/www_bget?KO:K10109 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA TMILIVN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TMILIVN PDB 2R6G http://www.ebi.ac.uk/pdbe-srv/view/entry/2R6G PDB 3FH6 http://www.ebi.ac.uk/pdbe-srv/view/entry/3FH6 PDB 3PUV http://www.ebi.ac.uk/pdbe-srv/view/entry/3PUV PDB 3PUW http://www.ebi.ac.uk/pdbe-srv/view/entry/3PUW PDB 3PUX http://www.ebi.ac.uk/pdbe-srv/view/entry/3PUX PDB 3PUY http://www.ebi.ac.uk/pdbe-srv/view/entry/3PUY PDB 3PUZ http://www.ebi.ac.uk/pdbe-srv/view/entry/3PUZ PDB 3PV0 http://www.ebi.ac.uk/pdbe-srv/view/entry/3PV0 PDB 3RLF http://www.ebi.ac.uk/pdbe-srv/view/entry/3RLF PDB 4JBW http://www.ebi.ac.uk/pdbe-srv/view/entry/4JBW PDB 4KHZ http://www.ebi.ac.uk/pdbe-srv/view/entry/4KHZ PDB 4KI0 http://www.ebi.ac.uk/pdbe-srv/view/entry/4KI0 PDBsum 2R6G http://www.ebi.ac.uk/pdbsum/2R6G PDBsum 3FH6 http://www.ebi.ac.uk/pdbsum/3FH6 PDBsum 3PUV http://www.ebi.ac.uk/pdbsum/3PUV PDBsum 3PUW http://www.ebi.ac.uk/pdbsum/3PUW PDBsum 3PUX http://www.ebi.ac.uk/pdbsum/3PUX PDBsum 3PUY http://www.ebi.ac.uk/pdbsum/3PUY PDBsum 3PUZ http://www.ebi.ac.uk/pdbsum/3PUZ PDBsum 3PV0 http://www.ebi.ac.uk/pdbsum/3PV0 PDBsum 3RLF http://www.ebi.ac.uk/pdbsum/3RLF PDBsum 4JBW http://www.ebi.ac.uk/pdbsum/4JBW PDBsum 4KHZ http://www.ebi.ac.uk/pdbsum/4KHZ PDBsum 4KI0 http://www.ebi.ac.uk/pdbsum/4KI0 PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:MALF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MALF_ECOLI PSORT-B swissprot:MALF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MALF_ECOLI PSORT2 swissprot:MALF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MALF_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Pfam PF14785 http://pfam.xfam.org/family/PF14785 Phobius swissprot:MALF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MALF_ECOLI PhylomeDB P02916 http://phylomedb.org/?seqid=P02916 ProteinModelPortal P02916 http://www.proteinmodelportal.org/query/uniprot/P02916 PubMed 10809785 http://www.ncbi.nlm.nih.gov/pubmed/10809785 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16453726 http://www.ncbi.nlm.nih.gov/pubmed/16453726 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18456666 http://www.ncbi.nlm.nih.gov/pubmed/18456666 PubMed 1915262 http://www.ncbi.nlm.nih.gov/pubmed/1915262 PubMed 2170984 http://www.ncbi.nlm.nih.gov/pubmed/2170984 PubMed 3000770 http://www.ncbi.nlm.nih.gov/pubmed/3000770 PubMed 6088520 http://www.ncbi.nlm.nih.gov/pubmed/6088520 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 8636026 http://www.ncbi.nlm.nih.gov/pubmed/8636026 PubMed 9214624 http://www.ncbi.nlm.nih.gov/pubmed/9214624 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9401026 http://www.ncbi.nlm.nih.gov/pubmed/9401026 PubMed 9529892 http://www.ncbi.nlm.nih.gov/pubmed/9529892 RefSeq NP_418457 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418457 RefSeq WP_001297290 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001297290 SMR P02916 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P02916 STRING 511145.b4033 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4033&targetmode=cogs STRING COG1175 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1175&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.1 http://www.tcdb.org/search/result.php?tc=3.A.1.1 UniProtKB MALF_ECOLI http://www.uniprot.org/uniprot/MALF_ECOLI UniProtKB-AC P02916 http://www.uniprot.org/uniprot/P02916 charge swissprot:MALF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MALF_ECOLI eggNOG COG1175 http://eggnogapi.embl.de/nog_data/html/tree/COG1175 eggNOG ENOG4105D56 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D56 epestfind swissprot:MALF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MALF_ECOLI garnier swissprot:MALF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MALF_ECOLI helixturnhelix swissprot:MALF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MALF_ECOLI hmoment swissprot:MALF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MALF_ECOLI iep swissprot:MALF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MALF_ECOLI inforesidue swissprot:MALF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MALF_ECOLI octanol swissprot:MALF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MALF_ECOLI pepcoil swissprot:MALF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MALF_ECOLI pepdigest swissprot:MALF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MALF_ECOLI pepinfo swissprot:MALF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MALF_ECOLI pepnet swissprot:MALF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MALF_ECOLI pepstats swissprot:MALF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MALF_ECOLI pepwheel swissprot:MALF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MALF_ECOLI pepwindow swissprot:MALF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MALF_ECOLI sigcleave swissprot:MALF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MALF_ECOLI ## Database ID URL or Descriptions # BRENDA 6.4.1 2026 # BioGrid 4259533 408 # EcoGene EG10275 accB # FUNCTION BCCP_ECOLI This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. {ECO 0000269|PubMed 4934522}. # GO_component GO:0005737 cytoplasm; IC:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0009317 acetyl-CoA carboxylase complex; IDA:EcoCyc. # GO_function GO:0003989 acetyl-CoA carboxylase activity; IMP:EcoliWiki. # GO_function GO:0009374 biotin binding; IDA:EcoCyc. # GO_process GO:0006633 fatty acid biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # INTERACTION BCCP_ECOLI P24182 accC; NbExp=6; IntAct=EBI-542320, EBI-542308; # IntAct P0ABD8 12 # InterPro IPR000089 Biotin_lipoyl # InterPro IPR001249 AcCoA_biotinCC # InterPro IPR001882 Biotin_BS # InterPro IPR011053 Single_hybrid_motif # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Pathway ko00061 Fatty acid biosynthesis # KEGG_Pathway ko00253 Tetracycline biosynthesis # KEGG_Pathway ko00620 Pyruvate metabolism # KEGG_Pathway ko00640 Propanoate metabolism # KEGG_Pathway ko00720 Carbon fixation pathways in prokaryotes # Organism BCCP_ECOLI Escherichia coli (strain K12) # PATHWAY BCCP_ECOLI Lipid metabolism; fatty acid biosynthesis. # PATRIC 32121940 VBIEscCol129921_3354 # PDB 1A6X NMR; -; A=70-156 # PDB 1BDO X-ray; 1.80 A; A=77-156 # PDB 1K67 Model; -; B=77-155 # PDB 1K69 Model; -; B=77-156 # PDB 2BDO NMR; -; A=77-156 # PDB 3BDO NMR; -; A=75-156 # PDB 4HR7 X-ray; 2.50 A; B/D/G/I=1-156 # PIR A93687 BKEC9 # PRINTS PR01071 ACOABIOTINCC # PROSITE PS00188 BIOTIN # PROSITE PS50968 BIOTINYL_LIPOYL # Pfam PF00364 Biotin_lipoyl # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Biotin carboxyl carrier protein of acetyl-CoA carboxylase {ECO:0000303|PubMed 4934522} # RefSeq NP_417721 NC_000913.3 # RefSeq WP_000354622 NZ_LN832404.1 # SIMILARITY Contains 1 biotinyl-binding domain. {ECO:0000255|PROSITE-ProRule PRU01066, ECO:0000305}. # SUBUNIT BCCP_ECOLI Homodimer. # SUPFAM SSF51230 SSF51230 # TIGRFAMs TIGR00531 BCCP # eggNOG COG0511 LUCA # eggNOG ENOG4105KM4 Bacteria BLAST swissprot:BCCP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BCCP_ECOLI BioCyc ECOL316407:JW3223-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3223-MONOMER BioCyc EcoCyc:BCCP-MONOMER http://biocyc.org/getid?id=EcoCyc:BCCP-MONOMER BioCyc MetaCyc:BCCP-MONOMER http://biocyc.org/getid?id=MetaCyc:BCCP-MONOMER COG COG0511 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0511 DIP DIP-48007N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48007N DOI 10.1006/jmbi.1998.1726 http://dx.doi.org/10.1006/jmbi.1998.1726 DOI 10.1016/S0969-2126(01)00277-5 http://dx.doi.org/10.1016/S0969-2126(01)00277-5 DOI 10.1021/bi971485f http://dx.doi.org/10.1021/bi971485f DOI 10.1021/bi982466o http://dx.doi.org/10.1021/bi982466o DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.68.7.1512 http://dx.doi.org/10.1073/pnas.68.7.1512 DOI 10.1073/pnas.88.21.9730 http://dx.doi.org/10.1073/pnas.88.21.9730 DOI 10.1089/dna.1989.8.779 http://dx.doi.org/10.1089/dna.1989.8.779 DOI 10.1093/nar/17.10.3982 http://dx.doi.org/10.1093/nar/17.10.3982 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M32214 http://www.ebi.ac.uk/ena/data/view/M32214 EMBL M79446 http://www.ebi.ac.uk/ena/data/view/M79446 EMBL M80458 http://www.ebi.ac.uk/ena/data/view/M80458 EMBL M83198 http://www.ebi.ac.uk/ena/data/view/M83198 EMBL S52932 http://www.ebi.ac.uk/ena/data/view/S52932 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X14825 http://www.ebi.ac.uk/ena/data/view/X14825 EchoBASE EB0271 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0271 EcoGene EG10275 http://www.ecogene.org/geneInfo.php?eg_id=EG10275 EnsemblBacteria AAC76287 http://www.ensemblgenomes.org/id/AAC76287 EnsemblBacteria AAC76287 http://www.ensemblgenomes.org/id/AAC76287 EnsemblBacteria BAE77296 http://www.ensemblgenomes.org/id/BAE77296 EnsemblBacteria BAE77296 http://www.ensemblgenomes.org/id/BAE77296 EnsemblBacteria BAE77296 http://www.ensemblgenomes.org/id/BAE77296 EnsemblBacteria b3255 http://www.ensemblgenomes.org/id/b3255 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0009317 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009317 GO_function GO:0003989 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003989 GO_function GO:0009374 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009374 GO_process GO:0006633 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006633 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 947758 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947758 HOGENOM HOG000008875 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000008875&db=HOGENOM6 InParanoid P0ABD8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABD8 IntAct P0ABD8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABD8* InterPro IPR000089 http://www.ebi.ac.uk/interpro/entry/IPR000089 InterPro IPR001249 http://www.ebi.ac.uk/interpro/entry/IPR001249 InterPro IPR001882 http://www.ebi.ac.uk/interpro/entry/IPR001882 InterPro IPR011053 http://www.ebi.ac.uk/interpro/entry/IPR011053 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Gene ecj:JW3223 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3223 KEGG_Gene eco:b3255 http://www.genome.jp/dbget-bin/www_bget?eco:b3255 KEGG_Orthology KO:K02160 http://www.genome.jp/dbget-bin/www_bget?KO:K02160 KEGG_Pathway ko00061 http://www.genome.jp/kegg-bin/show_pathway?ko00061 KEGG_Pathway ko00253 http://www.genome.jp/kegg-bin/show_pathway?ko00253 KEGG_Pathway ko00620 http://www.genome.jp/kegg-bin/show_pathway?ko00620 KEGG_Pathway ko00640 http://www.genome.jp/kegg-bin/show_pathway?ko00640 KEGG_Pathway ko00720 http://www.genome.jp/kegg-bin/show_pathway?ko00720 KEGG_Reaction rn:R00742 http://www.genome.jp/dbget-bin/www_bget?rn:R00742 KEGG_Reaction rn:R04386 http://www.genome.jp/dbget-bin/www_bget?rn:R04386 MINT MINT-1292848 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1292848 OMA KMFNQIE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KMFNQIE PDB 1A6X http://www.ebi.ac.uk/pdbe-srv/view/entry/1A6X PDB 1BDO http://www.ebi.ac.uk/pdbe-srv/view/entry/1BDO PDB 1K67 http://www.ebi.ac.uk/pdbe-srv/view/entry/1K67 PDB 1K69 http://www.ebi.ac.uk/pdbe-srv/view/entry/1K69 PDB 2BDO http://www.ebi.ac.uk/pdbe-srv/view/entry/2BDO PDB 3BDO http://www.ebi.ac.uk/pdbe-srv/view/entry/3BDO PDB 4HR7 http://www.ebi.ac.uk/pdbe-srv/view/entry/4HR7 PDBsum 1A6X http://www.ebi.ac.uk/pdbsum/1A6X PDBsum 1BDO http://www.ebi.ac.uk/pdbsum/1BDO PDBsum 1K67 http://www.ebi.ac.uk/pdbsum/1K67 PDBsum 1K69 http://www.ebi.ac.uk/pdbsum/1K69 PDBsum 2BDO http://www.ebi.ac.uk/pdbsum/2BDO PDBsum 3BDO http://www.ebi.ac.uk/pdbsum/3BDO PDBsum 4HR7 http://www.ebi.ac.uk/pdbsum/4HR7 PRINTS PR01071 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01071 PROSITE PS00188 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00188 PROSITE PS50968 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50968 PSORT swissprot:BCCP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BCCP_ECOLI PSORT-B swissprot:BCCP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BCCP_ECOLI PSORT2 swissprot:BCCP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BCCP_ECOLI Pfam PF00364 http://pfam.xfam.org/family/PF00364 Phobius swissprot:BCCP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BCCP_ECOLI PhylomeDB P0ABD8 http://phylomedb.org/?seqid=P0ABD8 ProteinModelPortal P0ABD8 http://www.proteinmodelportal.org/query/uniprot/P0ABD8 PubMed 10213607 http://www.ncbi.nlm.nih.gov/pubmed/10213607 PubMed 1370469 http://www.ncbi.nlm.nih.gov/pubmed/1370469 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1682920 http://www.ncbi.nlm.nih.gov/pubmed/1682920 PubMed 2575489 http://www.ncbi.nlm.nih.gov/pubmed/2575489 PubMed 2660106 http://www.ncbi.nlm.nih.gov/pubmed/2660106 PubMed 324999 http://www.ncbi.nlm.nih.gov/pubmed/324999 PubMed 4934522 http://www.ncbi.nlm.nih.gov/pubmed/4934522 PubMed 7678242 http://www.ncbi.nlm.nih.gov/pubmed/7678242 PubMed 8747466 http://www.ncbi.nlm.nih.gov/pubmed/8747466 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9398236 http://www.ncbi.nlm.nih.gov/pubmed/9398236 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 RefSeq NP_417721 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417721 RefSeq WP_000354622 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000354622 SMR P0ABD8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABD8 STRING 511145.b3255 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3255&targetmode=cogs STRING COG0511 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0511&targetmode=cogs SUPFAM SSF51230 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51230 SWISS-2DPAGE P0ABD8 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0ABD8 TIGRFAMs TIGR00531 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00531 UniProtKB BCCP_ECOLI http://www.uniprot.org/uniprot/BCCP_ECOLI UniProtKB-AC P0ABD8 http://www.uniprot.org/uniprot/P0ABD8 charge swissprot:BCCP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BCCP_ECOLI eggNOG COG0511 http://eggnogapi.embl.de/nog_data/html/tree/COG0511 eggNOG ENOG4105KM4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KM4 epestfind swissprot:BCCP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BCCP_ECOLI garnier swissprot:BCCP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BCCP_ECOLI helixturnhelix swissprot:BCCP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BCCP_ECOLI hmoment swissprot:BCCP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BCCP_ECOLI iep swissprot:BCCP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BCCP_ECOLI inforesidue swissprot:BCCP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BCCP_ECOLI octanol swissprot:BCCP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BCCP_ECOLI pepcoil swissprot:BCCP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BCCP_ECOLI pepdigest swissprot:BCCP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BCCP_ECOLI pepinfo swissprot:BCCP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BCCP_ECOLI pepnet swissprot:BCCP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BCCP_ECOLI pepstats swissprot:BCCP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BCCP_ECOLI pepwheel swissprot:BCCP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BCCP_ECOLI pepwindow swissprot:BCCP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BCCP_ECOLI sigcleave swissprot:BCCP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BCCP_ECOLI ## Database ID URL or Descriptions # DISRUPTION PHENOTYPE Mutants show decreased amounts of glmY. {ECO:0000269|PubMed 19843219}. # EcoGene EG11285 glrR # FUNCTION GLRR_ECOLI Member of the two-component regulatory system GlrR/GlrK that up-regulates transcription of the glmY sRNA when cells enter the stationary growth phase. Regulates glmY transcription by binding to three conserved sites in the purL-glmY intergenic region. {ECO 0000269|PubMed 19843219}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0000156 phosphorelay response regulator activity; IMP:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0000160 phosphorelay signal transduction system; IMP:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEP:EcoCyc. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; ISS:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.60 -; 1. # Gene3D 3.40.50.300 -; 1. # IntAct P0AFU4 9 # InterPro IPR001789 Sig_transdc_resp-reg_receiver # InterPro IPR002078 Sigma_54_int # InterPro IPR003593 AAA+_ATPase # InterPro IPR009057 Homeodomain-like # InterPro IPR011006 CheY-like_superfamily # InterPro IPR025662 Sigma_54_int_dom_ATP-bd_1 # InterPro IPR025943 Sigma_54_int_dom_ATP-bd_2 # InterPro IPR025944 Sigma_54_int_dom_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02022 M00502 GlrK-GlrR (amino sugar metabolism) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # MISCELLANEOUS GLRR_ECOLI Not required for the regulation of the glmY-glmZ- glmS regulatory cascade by glucosamine-6-phosphate depletion. # Organism GLRR_ECOLI Escherichia coli (strain K12) # PATRIC 32120507 VBIEscCol129921_2656 # PIR A65033 A65033 # PROSITE PS00675 SIGMA54_INTERACT_1 # PROSITE PS00676 SIGMA54_INTERACT_2 # PROSITE PS00688 SIGMA54_INTERACT_3 # PROSITE PS50045 SIGMA54_INTERACT_4 # PROSITE PS50110 RESPONSE_REGULATORY # PTM GLRR_ECOLI Phosphorylated by GlrK. {ECO 0000269|PubMed 15522865}. # Pfam PF00072 Response_reg # Pfam PF00158 Sigma54_activat # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLRR_ECOLI Transcriptional regulatory protein GlrR # RefSeq NP_417049 NC_000913.3 # RefSeq WP_001295369 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA79816.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Contains 1 response regulatory domain. {ECO:0000255|PROSITE-ProRule PRU00169}. # SIMILARITY Contains 1 sigma-54 factor interaction domain. {ECO:0000255|PROSITE-ProRule PRU00193}. # SMART SM00382 AAA # SMART SM00448 REC # SUBCELLULAR LOCATION GLRR_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF46689 SSF46689 # SUPFAM SSF52172 SSF52172 # SUPFAM SSF52540 SSF52540 # eggNOG COG2204 LUCA # eggNOG ENOG4105C1W Bacteria BLAST swissprot:GLRR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLRR_ECOLI BioCyc ECOL316407:JW2538-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2538-MONOMER BioCyc EcoCyc:EG11285-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11285-MONOMER COG COG2204 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2204 DIP DIP-12044N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12044N DOI 10.1007/BF00273586 http://dx.doi.org/10.1007/BF00273586 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M410104200 http://dx.doi.org/10.1074/jbc.M410104200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1365-2958.1993.tb01706.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb01706.x DOI 10.1111/j.1365-2958.2009.06918.x http://dx.doi.org/10.1111/j.1365-2958.2009.06918.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M16778 http://www.ebi.ac.uk/ena/data/view/M16778 EMBL S67014 http://www.ebi.ac.uk/ena/data/view/S67014 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36841 http://www.ebi.ac.uk/ena/data/view/U36841 EMBL Z21843 http://www.ebi.ac.uk/ena/data/view/Z21843 EchoBASE EB1262 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1262 EcoGene EG11285 http://www.ecogene.org/geneInfo.php?eg_id=EG11285 EnsemblBacteria AAC75607 http://www.ensemblgenomes.org/id/AAC75607 EnsemblBacteria AAC75607 http://www.ensemblgenomes.org/id/AAC75607 EnsemblBacteria BAA16462 http://www.ensemblgenomes.org/id/BAA16462 EnsemblBacteria BAA16462 http://www.ensemblgenomes.org/id/BAA16462 EnsemblBacteria BAA16462 http://www.ensemblgenomes.org/id/BAA16462 EnsemblBacteria b2554 http://www.ensemblgenomes.org/id/b2554 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000156 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000156 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947042 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947042 HOGENOM HOG000058489 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000058489&db=HOGENOM6 InParanoid P0AFU4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFU4 IntAct P0AFU4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFU4* InterPro IPR001789 http://www.ebi.ac.uk/interpro/entry/IPR001789 InterPro IPR002078 http://www.ebi.ac.uk/interpro/entry/IPR002078 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR011006 http://www.ebi.ac.uk/interpro/entry/IPR011006 InterPro IPR025662 http://www.ebi.ac.uk/interpro/entry/IPR025662 InterPro IPR025943 http://www.ebi.ac.uk/interpro/entry/IPR025943 InterPro IPR025944 http://www.ebi.ac.uk/interpro/entry/IPR025944 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW2538 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2538 KEGG_Gene eco:b2554 http://www.genome.jp/dbget-bin/www_bget?eco:b2554 KEGG_Orthology KO:K07715 http://www.genome.jp/dbget-bin/www_bget?KO:K07715 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 MINT MINT-1317436 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1317436 OMA HNKITEY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HNKITEY PROSITE PS00675 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00675 PROSITE PS00676 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00676 PROSITE PS00688 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00688 PROSITE PS50045 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50045 PROSITE PS50110 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50110 PSORT swissprot:GLRR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLRR_ECOLI PSORT-B swissprot:GLRR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLRR_ECOLI PSORT2 swissprot:GLRR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLRR_ECOLI Pfam PF00072 http://pfam.xfam.org/family/PF00072 Pfam PF00158 http://pfam.xfam.org/family/PF00158 Phobius swissprot:GLRR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLRR_ECOLI PhylomeDB P0AFU4 http://phylomedb.org/?seqid=P0AFU4 ProteinModelPortal P0AFU4 http://www.proteinmodelportal.org/query/uniprot/P0AFU4 PubMed 15522865 http://www.ncbi.nlm.nih.gov/pubmed/15522865 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19843219 http://www.ncbi.nlm.nih.gov/pubmed/19843219 PubMed 2034230 http://www.ncbi.nlm.nih.gov/pubmed/2034230 PubMed 2885322 http://www.ncbi.nlm.nih.gov/pubmed/2885322 PubMed 8226691 http://www.ncbi.nlm.nih.gov/pubmed/8226691 PubMed 8412694 http://www.ncbi.nlm.nih.gov/pubmed/8412694 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417049 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417049 RefSeq WP_001295369 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295369 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMART SM00448 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00448 SMR P0AFU4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFU4 STRING 511145.b2554 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2554&targetmode=cogs STRING COG2204 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2204&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF52172 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52172 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB GLRR_ECOLI http://www.uniprot.org/uniprot/GLRR_ECOLI UniProtKB-AC P0AFU4 http://www.uniprot.org/uniprot/P0AFU4 charge swissprot:GLRR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLRR_ECOLI eggNOG COG2204 http://eggnogapi.embl.de/nog_data/html/tree/COG2204 eggNOG ENOG4105C1W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C1W epestfind swissprot:GLRR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLRR_ECOLI garnier swissprot:GLRR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLRR_ECOLI helixturnhelix swissprot:GLRR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLRR_ECOLI hmoment swissprot:GLRR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLRR_ECOLI iep swissprot:GLRR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLRR_ECOLI inforesidue swissprot:GLRR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLRR_ECOLI octanol swissprot:GLRR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLRR_ECOLI pepcoil swissprot:GLRR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLRR_ECOLI pepdigest swissprot:GLRR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLRR_ECOLI pepinfo swissprot:GLRR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLRR_ECOLI pepnet swissprot:GLRR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLRR_ECOLI pepstats swissprot:GLRR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLRR_ECOLI pepwheel swissprot:GLRR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLRR_ECOLI pepwindow swissprot:GLRR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLRR_ECOLI sigcleave swissprot:GLRR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLRR_ECOLI ## Database ID URL or Descriptions # BioGrid 4261144 2 # EcoGene EG13230 ybhD # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0000986 bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR005119 LysR_subst-bd # InterPro IPR011991 WHTH_DNA-bd_dom # Organism YBHD_ECOLI Escherichia coli (strain K12) # PATRIC 32116737 VBIEscCol129921_0794 # PIR H64812 H64812 # PRINTS PR00039 HTHLYSR # PROSITE PS50931 HTH_LYSR # Pfam PF00126 HTH_1 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBHD_ECOLI Uncharacterized HTH-type transcriptional regulator YbhD # RefSeq NP_415289 NC_000913.3 # RefSeq WP_001350493 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA35432.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Contains 1 HTH lysR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00253}. # SUPFAM SSF46785 SSF46785 # eggNOG ENOG4105F04 Bacteria # eggNOG ENOG410XRIM LUCA BLAST swissprot:YBHD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBHD_ECOLI BioCyc ECOL316407:JW5896-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5896-MONOMER BioCyc EcoCyc:G6398-MONOMER http://biocyc.org/getid?id=EcoCyc:G6398-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U27192 http://www.ebi.ac.uk/ena/data/view/U27192 EchoBASE EB3019 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3019 EcoGene EG13230 http://www.ecogene.org/geneInfo.php?eg_id=EG13230 EnsemblBacteria AAC73855 http://www.ensemblgenomes.org/id/AAC73855 EnsemblBacteria AAC73855 http://www.ensemblgenomes.org/id/AAC73855 EnsemblBacteria BAA35432 http://www.ensemblgenomes.org/id/BAA35432 EnsemblBacteria BAA35432 http://www.ensemblgenomes.org/id/BAA35432 EnsemblBacteria BAA35432 http://www.ensemblgenomes.org/id/BAA35432 EnsemblBacteria b0768 http://www.ensemblgenomes.org/id/b0768 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000986 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000986 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 944869 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944869 HOGENOM HOG000233514 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000233514&db=HOGENOM6 InParanoid P52696 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P52696 InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW5896 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5896 KEGG_Gene eco:b0768 http://www.genome.jp/dbget-bin/www_bget?eco:b0768 OMA ESFHRAA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ESFHRAA PRINTS PR00039 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00039 PROSITE PS50931 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50931 PSORT swissprot:YBHD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBHD_ECOLI PSORT-B swissprot:YBHD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBHD_ECOLI PSORT2 swissprot:YBHD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBHD_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:YBHD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBHD_ECOLI PhylomeDB P52696 http://phylomedb.org/?seqid=P52696 ProteinModelPortal P52696 http://www.proteinmodelportal.org/query/uniprot/P52696 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415289 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415289 RefSeq WP_001350493 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001350493 SMR P52696 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P52696 STRING 511145.b0768 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0768&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB YBHD_ECOLI http://www.uniprot.org/uniprot/YBHD_ECOLI UniProtKB-AC P52696 http://www.uniprot.org/uniprot/P52696 charge swissprot:YBHD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBHD_ECOLI eggNOG ENOG4105F04 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F04 eggNOG ENOG410XRIM http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRIM epestfind swissprot:YBHD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBHD_ECOLI garnier swissprot:YBHD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBHD_ECOLI helixturnhelix swissprot:YBHD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBHD_ECOLI hmoment swissprot:YBHD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBHD_ECOLI iep swissprot:YBHD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBHD_ECOLI inforesidue swissprot:YBHD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBHD_ECOLI octanol swissprot:YBHD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBHD_ECOLI pepcoil swissprot:YBHD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBHD_ECOLI pepdigest swissprot:YBHD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBHD_ECOLI pepinfo swissprot:YBHD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBHD_ECOLI pepnet swissprot:YBHD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBHD_ECOLI pepstats swissprot:YBHD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBHD_ECOLI pepwheel swissprot:YBHD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBHD_ECOLI pepwindow swissprot:YBHD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBHD_ECOLI sigcleave swissprot:YBHD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBHD_ECOLI ## Database ID URL or Descriptions # BioGrid 4262045 218 # EcoGene EG14234 cusF # FUNCTION CUSF_ECOLI Part of a cation efflux system that mediates resistance to copper and silver. Binds one copper per polypeptide. {ECO 0000269|PubMed 11399769}. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IMP:EcoCyc. # GO_component GO:0042597 periplasmic space; IMP:EcoliWiki. # GO_function GO:0005507 copper ion binding; IDA:EcoCyc. # GO_function GO:0016530 metallochaperone activity; IDA:EcoliWiki. # GO_function GO:0016531 copper chaperone activity; IDA:EcoCyc. # GO_function GO:0046914 transition metal ion binding; IDA:EcoCyc. # GO_process GO:0006878 cellular copper ion homeostasis; IGI:EcoCyc. # GO_process GO:0010043 response to zinc ion; IEP:EcoCyc. # GO_process GO:0010272 response to silver ion; IMP:EcoCyc. # GO_process GO:0010273 detoxification of copper ion; IGI:EcoCyc. # GO_process GO:0046688 response to copper ion; IEP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0042592 homeostatic process # INDUCTION Transcriptionally regulated by CusR in response to copper and silver ions. {ECO:0000269|PubMed 11283292}. # IntAct P77214 2 # InterPro IPR021647 CusF_Ec # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko02020 Two-component system # MISCELLANEOUS CUSF_ECOLI The cus system plays an important role in copper tolerance under anaerobic growth and, under extreme copper stress, in aerobic growth. # Organism CUSF_ECOLI Escherichia coli (strain K12) # PATRIC 32116314 VBIEscCol129921_0597 # PDB 1ZEQ X-ray; 1.50 A; X=28-110 # PDB 2QCP X-ray; 1.00 A; X=32-110 # PDB 2VB2 X-ray; 1.70 A; X=23-110 # PDB 2VB3 X-ray; 2.33 A; X=23-110 # PDB 3E6Z X-ray; 1.00 A; X=32-110 # PIR C64790 C64790 # Pfam PF11604 CusF_Ec # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CUSF_ECOLI Cation efflux system protein CusF # RefSeq NP_415105 NC_000913.3 # RefSeq WP_000709870 NZ_LN832404.1 # SUBCELLULAR LOCATION CUSF_ECOLI Periplasm. # SUBUNIT CUSF_ECOLI The cus efflux system is composed of CusA, CusB, CusC and CusF. # TCDB 2.A.6.1 the resistance-nodulation-cell division (rnd) superfamily # eggNOG COG5569 LUCA # eggNOG ENOG410624V Bacteria BLAST swissprot:CUSF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CUSF_ECOLI BioCyc ECOL316407:JW0562-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0562-MONOMER BioCyc EcoCyc:G6321-MONOMER http://biocyc.org/getid?id=EcoCyc:G6321-MONOMER BioCyc MetaCyc:G6321-MONOMER http://biocyc.org/getid?id=MetaCyc:G6321-MONOMER COG COG5569 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG5569 DIP DIP-9350N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9350N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M104122200 http://dx.doi.org/10.1074/jbc.M104122200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.185.13.3804-3812.2003 http://dx.doi.org/10.1128/JB.185.13.3804-3812.2003 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB3985 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3985 EcoGene EG14234 http://www.ecogene.org/geneInfo.php?eg_id=EG14234 EnsemblBacteria AAC73674 http://www.ensemblgenomes.org/id/AAC73674 EnsemblBacteria AAC73674 http://www.ensemblgenomes.org/id/AAC73674 EnsemblBacteria BAA35207 http://www.ensemblgenomes.org/id/BAA35207 EnsemblBacteria BAA35207 http://www.ensemblgenomes.org/id/BAA35207 EnsemblBacteria BAA35207 http://www.ensemblgenomes.org/id/BAA35207 EnsemblBacteria b0573 http://www.ensemblgenomes.org/id/b0573 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0005507 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005507 GO_function GO:0016530 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016530 GO_function GO:0016531 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016531 GO_function GO:0046914 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046914 GO_process GO:0006878 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006878 GO_process GO:0010043 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010043 GO_process GO:0010272 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010272 GO_process GO:0010273 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010273 GO_process GO:0046688 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046688 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GeneID 945188 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945188 HOGENOM HOG000126315 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126315&db=HOGENOM6 InParanoid P77214 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77214 IntAct P77214 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77214* InterPro IPR021647 http://www.ebi.ac.uk/interpro/entry/IPR021647 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW0562 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0562 KEGG_Gene eco:b0573 http://www.genome.jp/dbget-bin/www_bget?eco:b0573 KEGG_Orthology KO:K07810 http://www.genome.jp/dbget-bin/www_bget?KO:K07810 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA PAWANDH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PAWANDH PDB 1ZEQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZEQ PDB 2QCP http://www.ebi.ac.uk/pdbe-srv/view/entry/2QCP PDB 2VB2 http://www.ebi.ac.uk/pdbe-srv/view/entry/2VB2 PDB 2VB3 http://www.ebi.ac.uk/pdbe-srv/view/entry/2VB3 PDB 3E6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3E6Z PDBsum 1ZEQ http://www.ebi.ac.uk/pdbsum/1ZEQ PDBsum 2QCP http://www.ebi.ac.uk/pdbsum/2QCP PDBsum 2VB2 http://www.ebi.ac.uk/pdbsum/2VB2 PDBsum 2VB3 http://www.ebi.ac.uk/pdbsum/2VB3 PDBsum 3E6Z http://www.ebi.ac.uk/pdbsum/3E6Z PSORT swissprot:CUSF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CUSF_ECOLI PSORT-B swissprot:CUSF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CUSF_ECOLI PSORT2 swissprot:CUSF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CUSF_ECOLI Pfam PF11604 http://pfam.xfam.org/family/PF11604 Phobius swissprot:CUSF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CUSF_ECOLI ProteinModelPortal P77214 http://www.proteinmodelportal.org/query/uniprot/P77214 PubMed 11283292 http://www.ncbi.nlm.nih.gov/pubmed/11283292 PubMed 11399769 http://www.ncbi.nlm.nih.gov/pubmed/11399769 PubMed 12813074 http://www.ncbi.nlm.nih.gov/pubmed/12813074 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415105 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415105 RefSeq WP_000709870 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000709870 SMR P77214 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77214 STRING 511145.b0573 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0573&targetmode=cogs STRING COG5569 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG5569&targetmode=cogs TCDB 2.A.6.1 http://www.tcdb.org/search/result.php?tc=2.A.6.1 UniProtKB CUSF_ECOLI http://www.uniprot.org/uniprot/CUSF_ECOLI UniProtKB-AC P77214 http://www.uniprot.org/uniprot/P77214 charge swissprot:CUSF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CUSF_ECOLI eggNOG COG5569 http://eggnogapi.embl.de/nog_data/html/tree/COG5569 eggNOG ENOG410624V http://eggnogapi.embl.de/nog_data/html/tree/ENOG410624V epestfind swissprot:CUSF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CUSF_ECOLI garnier swissprot:CUSF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CUSF_ECOLI helixturnhelix swissprot:CUSF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CUSF_ECOLI hmoment swissprot:CUSF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CUSF_ECOLI iep swissprot:CUSF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CUSF_ECOLI inforesidue swissprot:CUSF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CUSF_ECOLI octanol swissprot:CUSF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CUSF_ECOLI pepcoil swissprot:CUSF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CUSF_ECOLI pepdigest swissprot:CUSF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CUSF_ECOLI pepinfo swissprot:CUSF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CUSF_ECOLI pepnet swissprot:CUSF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CUSF_ECOLI pepstats swissprot:CUSF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CUSF_ECOLI pepwheel swissprot:CUSF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CUSF_ECOLI pepwindow swissprot:CUSF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CUSF_ECOLI sigcleave swissprot:CUSF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CUSF_ECOLI ## Database ID URL or Descriptions # BioGrid 4261604 126 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG13661 ybfO # GO_process GO:0097264 self proteolysis; IEA:InterPro. # GOslim_process GO:0008150 biological_process # IntAct P77779 11 # InterPro IPR001826 RHS # InterPro IPR022385 Rhs_assc_core # InterPro IPR031325 RHS_repeat # Organism YBFO_ECOLI Escherichia coli (strain K12) # PATRIC 48660637 VBIEscCol107702_0701 # PIR F64805 F64805 # PRINTS PR00394 RHSPROTEIN # Pfam PF03527 RHS # Pfam PF05593 RHS_repeat # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBFO_ECOLI Putative uncharacterized protein YbfO # RefSeq WP_000267514 NZ_LN832404.1 # SIMILARITY Belongs to the RHS family. {ECO 0000305}. # TIGRFAMs TIGR03696 Rhs_assc_core # eggNOG COG3209 LUCA # eggNOG ENOG4105CNA Bacteria BLAST swissprot:YBFO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBFO_ECOLI BioCyc ECOL316407:JW0692-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0692-MONOMER BioCyc EcoCyc:G6376-MONOMER http://biocyc.org/getid?id=EcoCyc:G6376-MONOMER DIP DIP-11386N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11386N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG13661 http://www.ecogene.org/geneInfo.php?eg_id=EG13661 EnsemblBacteria BAA35361 http://www.ensemblgenomes.org/id/BAA35361 EnsemblBacteria BAA35361 http://www.ensemblgenomes.org/id/BAA35361 EnsemblBacteria BAA35361 http://www.ensemblgenomes.org/id/BAA35361 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0097264 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097264 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 HOGENOM HOG000009379 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009379&db=HOGENOM6 IntAct P77779 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77779* InterPro IPR001826 http://www.ebi.ac.uk/interpro/entry/IPR001826 InterPro IPR022385 http://www.ebi.ac.uk/interpro/entry/IPR022385 InterPro IPR031325 http://www.ebi.ac.uk/interpro/entry/IPR031325 KEGG_Gene ecj:JW0692 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0692 PRINTS PR00394 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00394 PSORT swissprot:YBFO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBFO_ECOLI PSORT-B swissprot:YBFO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBFO_ECOLI PSORT2 swissprot:YBFO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBFO_ECOLI Pfam PF03527 http://pfam.xfam.org/family/PF03527 Pfam PF05593 http://pfam.xfam.org/family/PF05593 Phobius swissprot:YBFO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBFO_ECOLI PhylomeDB P77779 http://phylomedb.org/?seqid=P77779 ProteinModelPortal P77779 http://www.proteinmodelportal.org/query/uniprot/P77779 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000267514 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000267514 STRING 511145.b3593 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3593&targetmode=cogs TIGRFAMs TIGR03696 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03696 UniProtKB YBFO_ECOLI http://www.uniprot.org/uniprot/YBFO_ECOLI UniProtKB-AC P77779 http://www.uniprot.org/uniprot/P77779 charge swissprot:YBFO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBFO_ECOLI eggNOG COG3209 http://eggnogapi.embl.de/nog_data/html/tree/COG3209 eggNOG ENOG4105CNA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CNA epestfind swissprot:YBFO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBFO_ECOLI garnier swissprot:YBFO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBFO_ECOLI helixturnhelix swissprot:YBFO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBFO_ECOLI hmoment swissprot:YBFO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBFO_ECOLI iep swissprot:YBFO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBFO_ECOLI inforesidue swissprot:YBFO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBFO_ECOLI octanol swissprot:YBFO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBFO_ECOLI pepcoil swissprot:YBFO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBFO_ECOLI pepdigest swissprot:YBFO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBFO_ECOLI pepinfo swissprot:YBFO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBFO_ECOLI pepnet swissprot:YBFO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBFO_ECOLI pepstats swissprot:YBFO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBFO_ECOLI pepwheel swissprot:YBFO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBFO_ECOLI pepwindow swissprot:YBFO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBFO_ECOLI sigcleave swissprot:YBFO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBFO_ECOLI ## Database ID URL or Descriptions # AltName WZZB_ECOLI Polysaccharide antigen chain regulator # BioGrid 4261360 320 # EcoGene EG13406 wzzB # FUNCTION WZZB_ECOLI Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # InterPro IPR003856 LipoPS_biosynth # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # Organism WZZB_ECOLI Escherichia coli (strain K12) # PATHWAY WZZB_ECOLI Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. # PATRIC 32119389 VBIEscCol129921_2104 # Pfam PF02706 Wzz # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName WZZB_ECOLI Chain length determinant protein # RefSeq NP_416531 NC_000913.3 # RefSeq WP_001393575 NZ_LN832404.1 # SIMILARITY Belongs to the WzzB/Cld/Rol family. {ECO 0000305}. # SUBCELLULAR LOCATION WZZB_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 16079137}; Multi- pass membrane protein {ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 16079137}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 16079137}. # eggNOG COG3765 LUCA # eggNOG ENOG4108KPN Bacteria BLAST swissprot:WZZB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:WZZB_ECOLI BioCyc ECOL316407:JW5836-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5836-MONOMER BioCyc EcoCyc:G7090-MONOMER http://biocyc.org/getid?id=EcoCyc:G7090-MONOMER COG COG3765 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3765 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL Y07559 http://www.ebi.ac.uk/ena/data/view/Y07559 EchoBASE EB3182 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3182 EcoGene EG13406 http://www.ecogene.org/geneInfo.php?eg_id=EG13406 EnsemblBacteria AAC75088 http://www.ensemblgenomes.org/id/AAC75088 EnsemblBacteria AAC75088 http://www.ensemblgenomes.org/id/AAC75088 EnsemblBacteria BAA15859 http://www.ensemblgenomes.org/id/BAA15859 EnsemblBacteria BAA15859 http://www.ensemblgenomes.org/id/BAA15859 EnsemblBacteria BAA15859 http://www.ensemblgenomes.org/id/BAA15859 EnsemblBacteria b2027 http://www.ensemblgenomes.org/id/b2027 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 946553 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946553 HOGENOM HOG000121918 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000121918&db=HOGENOM6 InParanoid P76372 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76372 InterPro IPR003856 http://www.ebi.ac.uk/interpro/entry/IPR003856 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Gene ecj:JW5836 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5836 KEGG_Gene eco:b2027 http://www.genome.jp/dbget-bin/www_bget?eco:b2027 KEGG_Orthology KO:K05789 http://www.genome.jp/dbget-bin/www_bget?KO:K05789 OMA DNIALRM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DNIALRM PSORT swissprot:WZZB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:WZZB_ECOLI PSORT-B swissprot:WZZB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:WZZB_ECOLI PSORT2 swissprot:WZZB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:WZZB_ECOLI Pfam PF02706 http://pfam.xfam.org/family/PF02706 Phobius swissprot:WZZB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:WZZB_ECOLI PhylomeDB P76372 http://phylomedb.org/?seqid=P76372 ProteinModelPortal P76372 http://www.proteinmodelportal.org/query/uniprot/P76372 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416531 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416531 RefSeq WP_001393575 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001393575 SMR P76372 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76372 STRING 511145.b2027 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2027&targetmode=cogs STRING COG3765 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3765&targetmode=cogs UniProtKB WZZB_ECOLI http://www.uniprot.org/uniprot/WZZB_ECOLI UniProtKB-AC P76372 http://www.uniprot.org/uniprot/P76372 charge swissprot:WZZB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:WZZB_ECOLI eggNOG COG3765 http://eggnogapi.embl.de/nog_data/html/tree/COG3765 eggNOG ENOG4108KPN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108KPN epestfind swissprot:WZZB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:WZZB_ECOLI garnier swissprot:WZZB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:WZZB_ECOLI helixturnhelix swissprot:WZZB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:WZZB_ECOLI hmoment swissprot:WZZB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:WZZB_ECOLI iep swissprot:WZZB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:WZZB_ECOLI inforesidue swissprot:WZZB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:WZZB_ECOLI octanol swissprot:WZZB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:WZZB_ECOLI pepcoil swissprot:WZZB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:WZZB_ECOLI pepdigest swissprot:WZZB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:WZZB_ECOLI pepinfo swissprot:WZZB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:WZZB_ECOLI pepnet swissprot:WZZB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:WZZB_ECOLI pepstats swissprot:WZZB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:WZZB_ECOLI pepwheel swissprot:WZZB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:WZZB_ECOLI pepwindow swissprot:WZZB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:WZZB_ECOLI sigcleave swissprot:WZZB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:WZZB_ECOLI ## Database ID URL or Descriptions # BioGrid 4262302 11 # EcoGene EG13076 ygdR # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GOslim_component GO:0005886 plasma membrane # InterPro IPR010305 DUF903 # InterPro IPR010920 LSM_dom # Organism YGDR_ECOLI Escherichia coli (strain K12) # PATRIC 32121084 VBIEscCol129921_2931 # PDB 2JN0 NMR; -; A=21-72 # PDB 3FIF X-ray; 2.70 A; A/B/C/D/E/F/G/H=21-72 # PIR B65066 B65066 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF06004 DUF903 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGDR_ECOLI Uncharacterized lipoprotein YgdR # RefSeq NP_417310 NC_000913.3 # RefSeq WP_000758655 NZ_LN832404.1 # SIMILARITY To E.coli YgdI. {ECO 0000305}. # SUBCELLULAR LOCATION YGDR_ECOLI Cell membrane {ECO 0000255|PROSITE- ProRule PRU00303}; Lipid-anchor {ECO 0000255|PROSITE- ProRule PRU00303}. # SUPFAM SSF50182 SSF50182 # eggNOG ENOG4105SUV Bacteria # eggNOG ENOG4111UKF LUCA BLAST swissprot:YGDR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGDR_ECOLI BioCyc ECOL316407:JW2801-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2801-MONOMER BioCyc EcoCyc:G7461-MONOMER http://biocyc.org/getid?id=EcoCyc:G7461-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 EchoBASE EB2886 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2886 EcoGene EG13076 http://www.ecogene.org/geneInfo.php?eg_id=EG13076 EnsemblBacteria AAC75872 http://www.ensemblgenomes.org/id/AAC75872 EnsemblBacteria AAC75872 http://www.ensemblgenomes.org/id/AAC75872 EnsemblBacteria BAE76902 http://www.ensemblgenomes.org/id/BAE76902 EnsemblBacteria BAE76902 http://www.ensemblgenomes.org/id/BAE76902 EnsemblBacteria BAE76902 http://www.ensemblgenomes.org/id/BAE76902 EnsemblBacteria b2833 http://www.ensemblgenomes.org/id/b2833 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 947304 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947304 HOGENOM HOG000282509 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000282509&db=HOGENOM6 IntAct P65294 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P65294* InterPro IPR010305 http://www.ebi.ac.uk/interpro/entry/IPR010305 InterPro IPR010920 http://www.ebi.ac.uk/interpro/entry/IPR010920 KEGG_Gene ecj:JW2801 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2801 KEGG_Gene eco:b2833 http://www.genome.jp/dbget-bin/www_bget?eco:b2833 OMA AVMISGC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AVMISGC PDB 2JN0 http://www.ebi.ac.uk/pdbe-srv/view/entry/2JN0 PDB 3FIF http://www.ebi.ac.uk/pdbe-srv/view/entry/3FIF PDBsum 2JN0 http://www.ebi.ac.uk/pdbsum/2JN0 PDBsum 3FIF http://www.ebi.ac.uk/pdbsum/3FIF PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YGDR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGDR_ECOLI PSORT-B swissprot:YGDR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGDR_ECOLI PSORT2 swissprot:YGDR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGDR_ECOLI Pfam PF06004 http://pfam.xfam.org/family/PF06004 Phobius swissprot:YGDR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGDR_ECOLI ProteinModelPortal P65294 http://www.proteinmodelportal.org/query/uniprot/P65294 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417310 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417310 RefSeq WP_000758655 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000758655 SMR P65294 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P65294 STRING 511145.b2833 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2833&targetmode=cogs SUPFAM SSF50182 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50182 UniProtKB YGDR_ECOLI http://www.uniprot.org/uniprot/YGDR_ECOLI UniProtKB-AC P65294 http://www.uniprot.org/uniprot/P65294 charge swissprot:YGDR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGDR_ECOLI eggNOG ENOG4105SUV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105SUV eggNOG ENOG4111UKF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111UKF epestfind swissprot:YGDR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGDR_ECOLI garnier swissprot:YGDR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGDR_ECOLI helixturnhelix swissprot:YGDR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGDR_ECOLI hmoment swissprot:YGDR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGDR_ECOLI iep swissprot:YGDR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGDR_ECOLI inforesidue swissprot:YGDR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGDR_ECOLI octanol swissprot:YGDR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGDR_ECOLI pepcoil swissprot:YGDR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGDR_ECOLI pepdigest swissprot:YGDR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGDR_ECOLI pepinfo swissprot:YGDR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGDR_ECOLI pepnet swissprot:YGDR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGDR_ECOLI pepstats swissprot:YGDR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGDR_ECOLI pepwheel swissprot:YGDR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGDR_ECOLI pepwindow swissprot:YGDR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGDR_ECOLI sigcleave swissprot:YGDR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGDR_ECOLI ## Database ID URL or Descriptions # AltName ETTA_ECOLI Translational regulatory factor EttA # BioGrid 4260798 5 # DISRUPTION PHENOTYPE Not essential it can be disrupted, its absence impairs fitness in long-term (up to 6 days) growth in stationary phase. {ECO:0000269|PubMed 24389466}. # DOMAIN ETTA_ECOLI The P-site tRNA interaction motif (PtIM domain, residues 242-322) probably interacts with the P site tRNA(fMet) as well as the 23S rRNA. # DOMAIN ETTA_ECOLI The arm domain (residues 95-139) is inserted in the first ABC transporter domain. Its deletion abrogates the growth arrest and translation inhibition effect of the double Q-188/Q-470 mutation. When deleted impairs fitness in long-term (up to 6 days) growth in stationary phase (PubMed 24389466). Probably contacts ribosomal protein L1 (PubMed 24389465). {ECO 0000269|PubMed 24389465, ECO 0000269|PubMed 24389466}. # EcoGene EG12343 ettA # FUNCTION ETTA_ECOLI A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E site where it modulates the state of the translating ribosome during subunit translocation. Stimulates dipeptide bond synthesis in the presence of ATP (cell in high energy state), but inhibits dipeptide synthesis in the presence of ADP (cell in low energy state), and thus may control translation in response to changing ATP levels (including during stationary phase). Following ATP hydrolysis is probably released allowing the ribosome to enter the elongation phase. Its specificity for the IC may be conferred by its recognition of features unique to tRNA(fMet). {ECO 0000269|PubMed 24389465, ECO 0000269|PubMed 24389466}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0000049 tRNA binding; IEA:UniProtKB-KW. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016887 ATPase activity; IDA:EcoCyc. # GO_function GO:0019843 rRNA binding; IEA:UniProtKB-KW. # GO_function GO:0043022 ribosome binding; IMP:EcoCyc. # GO_process GO:0006412 translation; IEA:UniProtKB-KW. # GO_process GO:0045900 negative regulation of translational elongation; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0019843 rRNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006412 translation # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.300 -; 3. # INDUCTION Constitutively expressed, increases in stationary phase (at protein level). {ECO:0000269|PubMed 24389466}. # IntAct P0A9W3 8 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR017871 ABC_transporter_CS # InterPro IPR022374 ABC_ATP-bd_ChvD # InterPro IPR027417 P-loop_NTPase # InterPro IPR032781 ABC_tran_Xtn # Organism ETTA_ECOLI Escherichia coli (strain K12) # PATRIC 32124400 VBIEscCol129921_4540 # PDB 3J5S EM; 7.50 A; D=1-555 # PDB 4FIN X-ray; 2.40 A; A/B=1-555 # PIR F65254 F65254 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2; 2 # Pfam PF00005 ABC_tran; 2 # Pfam PF12848 ABC_tran_Xtn # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ETTA_ECOLI Energy-dependent translational throttle protein EttA # RefSeq NP_418808 NC_000913.3 # RefSeq WP_000046749 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97287.1; Type=Frameshift; Positions=541; Evidence={ECO:0000305}; Sequence=M69185; Type=Frameshift; Positions=49; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily. {ECO 0000305}. # SIMILARITY Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA; 2 # SUBCELLULAR LOCATION ETTA_ECOLI Cytoplasm {ECO 0000269|PubMed 24389466}. Note=Associates with ribosomes and polysomes. # SUBUNIT ETTA_ECOLI Monomer at concentrations found in vivo, exists in a slowly reversible monomer-homodimer equilibrium. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P site containing tRNA(fMet). {ECO 0000269|PubMed 24389465, ECO 0000269|PubMed 24389466}. # SUPFAM SSF52540 SSF52540; 2 # TIGRFAMs TIGR03719 ABC_ABC_ChvD # eggNOG COG0488 LUCA # eggNOG ENOG4105C5H Bacteria BLAST swissprot:ETTA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ETTA_ECOLI BioCyc ECOL316407:JW4354-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4354-MONOMER BioCyc EcoCyc:YJJK-MONOMER http://biocyc.org/getid?id=EcoCyc:YJJK-MONOMER DIP DIP-48138N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48138N DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsmb.2740 http://dx.doi.org/10.1038/nsmb.2740 DOI 10.1038/nsmb.2741 http://dx.doi.org/10.1038/nsmb.2741 DOI 10.1038/nsmb.2765 http://dx.doi.org/10.1038/nsmb.2765 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M69185 http://www.ebi.ac.uk/ena/data/view/M69185 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2247 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2247 EcoGene EG12343 http://www.ecogene.org/geneInfo.php?eg_id=EG12343 EnsemblBacteria AAC77344 http://www.ensemblgenomes.org/id/AAC77344 EnsemblBacteria AAC77344 http://www.ensemblgenomes.org/id/AAC77344 EnsemblBacteria BAE78380 http://www.ensemblgenomes.org/id/BAE78380 EnsemblBacteria BAE78380 http://www.ensemblgenomes.org/id/BAE78380 EnsemblBacteria BAE78380 http://www.ensemblgenomes.org/id/BAE78380 EnsemblBacteria b4391 http://www.ensemblgenomes.org/id/b4391 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000049 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GO_function GO:0043022 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043022 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GO_process GO:0045900 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045900 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948909 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948909 HOGENOM HOG000271639 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000271639&db=HOGENOM6 InParanoid P0A9W3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9W3 IntAct P0A9W3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9W3* InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR022374 http://www.ebi.ac.uk/interpro/entry/IPR022374 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR032781 http://www.ebi.ac.uk/interpro/entry/IPR032781 KEGG_Gene ecj:JW4354 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4354 KEGG_Gene eco:b4391 http://www.genome.jp/dbget-bin/www_bget?eco:b4391 MINT MINT-1222078 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1222078 OMA KVIEFQD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KVIEFQD PDB 3J5S http://www.ebi.ac.uk/pdbe-srv/view/entry/3J5S PDB 4FIN http://www.ebi.ac.uk/pdbe-srv/view/entry/4FIN PDBsum 3J5S http://www.ebi.ac.uk/pdbsum/3J5S PDBsum 4FIN http://www.ebi.ac.uk/pdbsum/4FIN PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:ETTA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ETTA_ECOLI PSORT-B swissprot:ETTA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ETTA_ECOLI PSORT2 swissprot:ETTA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ETTA_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Pfam PF12848 http://pfam.xfam.org/family/PF12848 Phobius swissprot:ETTA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ETTA_ECOLI PhylomeDB P0A9W3 http://phylomedb.org/?seqid=P0A9W3 ProteinModelPortal P0A9W3 http://www.proteinmodelportal.org/query/uniprot/P0A9W3 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1938883 http://www.ncbi.nlm.nih.gov/pubmed/1938883 PubMed 24389465 http://www.ncbi.nlm.nih.gov/pubmed/24389465 PubMed 24389466 http://www.ncbi.nlm.nih.gov/pubmed/24389466 PubMed 24500425 http://www.ncbi.nlm.nih.gov/pubmed/24500425 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_418808 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418808 RefSeq WP_000046749 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000046749 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P0A9W3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9W3 STRING 511145.b4391 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4391&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR03719 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03719 UniProtKB ETTA_ECOLI http://www.uniprot.org/uniprot/ETTA_ECOLI UniProtKB-AC P0A9W3 http://www.uniprot.org/uniprot/P0A9W3 charge swissprot:ETTA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ETTA_ECOLI eggNOG COG0488 http://eggnogapi.embl.de/nog_data/html/tree/COG0488 eggNOG ENOG4105C5H http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C5H epestfind swissprot:ETTA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ETTA_ECOLI garnier swissprot:ETTA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ETTA_ECOLI helixturnhelix swissprot:ETTA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ETTA_ECOLI hmoment swissprot:ETTA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ETTA_ECOLI iep swissprot:ETTA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ETTA_ECOLI inforesidue swissprot:ETTA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ETTA_ECOLI octanol swissprot:ETTA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ETTA_ECOLI pepcoil swissprot:ETTA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ETTA_ECOLI pepdigest swissprot:ETTA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ETTA_ECOLI pepinfo swissprot:ETTA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ETTA_ECOLI pepnet swissprot:ETTA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ETTA_ECOLI pepstats swissprot:ETTA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ETTA_ECOLI pepwheel swissprot:ETTA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ETTA_ECOLI pepwindow swissprot:ETTA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ETTA_ECOLI sigcleave swissprot:ETTA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ETTA_ECOLI ## Database ID URL or Descriptions # AltName DAUA_ECOLI Dicarboxylic acid uptake system A # BioGrid 4259558 626 # DISRUPTION PHENOTYPE Mutant is metabolically inactive when succinate is used as sole carbon source. Does not affect growth on glucose, fructose, maltose and glycerol. {ECO:0000269|PubMed 23278959}. # EcoGene EG12392 dauA # FUNCTION DAUA_ECOLI Responsible for the aerobic transport of succinate from the periplasm to the cytoplasm at acidic pH. Can transport other C4-dicarboxylic acids such as aspartate and fumarate. May also play a role in the regulation of C4-dicarboxylic acid metabolism at pH 7, via regulation of expression and/or activity of DctA. May act as a co-sensor of DcuS. {ECO 0000269|PubMed 23278959}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0008271 secondary active sulfate transmembrane transporter activity; IEA:InterPro. # GO_function GO:0015116 sulfate transmembrane transporter activity; IBA:GO_Central. # GO_function GO:0015138 fumarate transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0015141 succinate transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0015183 L-aspartate transmembrane transporter activity; IDA:EcoCyc. # GO_process GO:0015741 fumarate transport; IDA:EcoCyc. # GO_process GO:0015810 aspartate transport; IDA:EcoCyc. # GO_process GO:0071422 succinate transmembrane transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # Gene3D 3.30.750.24 -; 1. # InterPro IPR001902 SLC26A/SulP_fam # InterPro IPR002645 STAS_dom # InterPro IPR011547 SLC26A/SulP_dom # InterPro IPR018045 S04_transporter_CS # KEGG_Brite ko02000 Transporters # Organism DAUA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11814 PTHR11814 # PATRIC 32117664 VBIEscCol129921_1254 # PDB 3NY7 X-ray; 1.92 A; A=445-559 # PIR C64867 C64867 # PROSITE PS01130 SLC26A # PROSITE PS50801 STAS # Pfam PF00916 Sulfate_transp # Pfam PF01740 STAS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DAUA_ECOLI C4-dicarboxylic acid transporter DauA # RefSeq NP_415724 NC_000913.3 # SIMILARITY Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. {ECO 0000305}. # SIMILARITY Contains 1 STAS domain. {ECO:0000255|PROSITE- ProRule PRU00198}. # SUBCELLULAR LOCATION DAUA_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 23278959}; Multi- pass membrane protein {ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 23278959}. # SUPFAM SSF52091 SSF52091 # TCDB 2.A.53.3.11 the sulfate permease (sulp) family # TIGRFAMs TIGR00815 sulP # eggNOG COG0659 LUCA # eggNOG ENOG4105CHH Bacteria BLAST swissprot:DAUA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DAUA_ECOLI BioCyc ECOL316407:JW5189-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5189-MONOMER BioCyc EcoCyc:YCHM-MONOMER http://biocyc.org/getid?id=EcoCyc:YCHM-MONOMER BioCyc MetaCyc:YCHM-MONOMER http://biocyc.org/getid?id=MetaCyc:YCHM-MONOMER COG COG0659 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0659 DIP DIP-48160N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48160N DOI 10.1016/0968-0004(94)90168-6 http://dx.doi.org/10.1016/0968-0004(94)90168-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1111/mmi.12120 http://dx.doi.org/10.1111/mmi.12120 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M13174 http://www.ebi.ac.uk/ena/data/view/M13174 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X53983 http://www.ebi.ac.uk/ena/data/view/X53983 EchoBASE EB2293 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2293 EcoGene EG12392 http://www.ecogene.org/geneInfo.php?eg_id=EG12392 EnsemblBacteria AAC74290 http://www.ensemblgenomes.org/id/AAC74290 EnsemblBacteria AAC74290 http://www.ensemblgenomes.org/id/AAC74290 EnsemblBacteria BAA36064 http://www.ensemblgenomes.org/id/BAA36064 EnsemblBacteria BAA36064 http://www.ensemblgenomes.org/id/BAA36064 EnsemblBacteria BAA36064 http://www.ensemblgenomes.org/id/BAA36064 EnsemblBacteria b1206 http://www.ensemblgenomes.org/id/b1206 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0008271 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008271 GO_function GO:0015116 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015116 GO_function GO:0015138 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015138 GO_function GO:0015141 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015141 GO_function GO:0015183 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015183 GO_process GO:0015741 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015741 GO_process GO:0015810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015810 GO_process GO:0071422 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071422 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 3.30.750.24 http://www.cathdb.info/version/latest/superfamily/3.30.750.24 GeneID 945770 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945770 HOGENOM HOG000236211 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000236211&db=HOGENOM6 InParanoid P0AFR2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFR2 InterPro IPR001902 http://www.ebi.ac.uk/interpro/entry/IPR001902 InterPro IPR002645 http://www.ebi.ac.uk/interpro/entry/IPR002645 InterPro IPR011547 http://www.ebi.ac.uk/interpro/entry/IPR011547 InterPro IPR018045 http://www.ebi.ac.uk/interpro/entry/IPR018045 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5189 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5189 KEGG_Gene eco:b1206 http://www.genome.jp/dbget-bin/www_bget?eco:b1206 KEGG_Orthology KO:K03321 http://www.genome.jp/dbget-bin/www_bget?KO:K03321 OMA GMEADNP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GMEADNP PANTHER PTHR11814 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11814 PDB 3NY7 http://www.ebi.ac.uk/pdbe-srv/view/entry/3NY7 PDBsum 3NY7 http://www.ebi.ac.uk/pdbsum/3NY7 PROSITE PS01130 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01130 PROSITE PS50801 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50801 PSORT swissprot:DAUA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DAUA_ECOLI PSORT-B swissprot:DAUA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DAUA_ECOLI PSORT2 swissprot:DAUA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DAUA_ECOLI Pfam PF00916 http://pfam.xfam.org/family/PF00916 Pfam PF01740 http://pfam.xfam.org/family/PF01740 Phobius swissprot:DAUA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DAUA_ECOLI PhylomeDB P0AFR2 http://phylomedb.org/?seqid=P0AFR2 ProteinModelPortal P0AFR2 http://www.proteinmodelportal.org/query/uniprot/P0AFR2 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 23278959 http://www.ncbi.nlm.nih.gov/pubmed/23278959 PubMed 3009477 http://www.ncbi.nlm.nih.gov/pubmed/3009477 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 8140616 http://www.ncbi.nlm.nih.gov/pubmed/8140616 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415724 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415724 SMR P0AFR2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFR2 STRING 511145.b1206 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1206&targetmode=cogs STRING COG0659 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0659&targetmode=cogs SUPFAM SSF52091 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52091 TCDB 2.A.53.3.11 http://www.tcdb.org/search/result.php?tc=2.A.53.3.11 TIGRFAMs TIGR00815 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00815 UniProtKB DAUA_ECOLI http://www.uniprot.org/uniprot/DAUA_ECOLI UniProtKB-AC P0AFR2 http://www.uniprot.org/uniprot/P0AFR2 charge swissprot:DAUA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DAUA_ECOLI eggNOG COG0659 http://eggnogapi.embl.de/nog_data/html/tree/COG0659 eggNOG ENOG4105CHH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CHH epestfind swissprot:DAUA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DAUA_ECOLI garnier swissprot:DAUA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DAUA_ECOLI helixturnhelix swissprot:DAUA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DAUA_ECOLI hmoment swissprot:DAUA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DAUA_ECOLI iep swissprot:DAUA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DAUA_ECOLI inforesidue swissprot:DAUA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DAUA_ECOLI octanol swissprot:DAUA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DAUA_ECOLI pepcoil swissprot:DAUA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DAUA_ECOLI pepdigest swissprot:DAUA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DAUA_ECOLI pepinfo swissprot:DAUA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DAUA_ECOLI pepnet swissprot:DAUA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DAUA_ECOLI pepstats swissprot:DAUA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DAUA_ECOLI pepwheel swissprot:DAUA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DAUA_ECOLI pepwindow swissprot:DAUA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DAUA_ECOLI sigcleave swissprot:DAUA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DAUA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259759 17 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG13333 yafU # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # Organism YAFU_ECOLI Escherichia coli (strain K12) # PIR C64746 C64746 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAFU_ECOLI Putative inner membrane protein YafU # RefSeq WP_000093703 NZ_LN832404.1 # SUBCELLULAR LOCATION YAFU_ECOLI Cell inner membrane; Multi-pass membrane protein. Note=When overexpressed. BLAST swissprot:YAFU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAFU_ECOLI BioCyc ECOL316407:JW0207-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0207-MONOMER BioCyc EcoCyc:G6102-MONOMER http://biocyc.org/getid?id=EcoCyc:G6102-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EchoBASE EB3117 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3117 EcoGene EG13333 http://www.ecogene.org/geneInfo.php?eg_id=EG13333 EnsemblBacteria BAE76046 http://www.ensemblgenomes.org/id/BAE76046 EnsemblBacteria BAE76046 http://www.ensemblgenomes.org/id/BAE76046 EnsemblBacteria BAE76046 http://www.ensemblgenomes.org/id/BAE76046 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 HOGENOM HOG000202505 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000202505&db=HOGENOM6 KEGG_Gene ecj:JW0207 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0207 OMA MRTIEFI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MRTIEFI PSORT swissprot:YAFU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAFU_ECOLI PSORT-B swissprot:YAFU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAFU_ECOLI PSORT2 swissprot:YAFU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAFU_ECOLI Phobius swissprot:YAFU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAFU_ECOLI ProteinModelPortal P77354 http://www.proteinmodelportal.org/query/uniprot/P77354 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000093703 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000093703 UniProtKB YAFU_ECOLI http://www.uniprot.org/uniprot/YAFU_ECOLI UniProtKB-AC P77354 http://www.uniprot.org/uniprot/P77354 charge swissprot:YAFU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAFU_ECOLI epestfind swissprot:YAFU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAFU_ECOLI garnier swissprot:YAFU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAFU_ECOLI helixturnhelix swissprot:YAFU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAFU_ECOLI hmoment swissprot:YAFU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAFU_ECOLI iep swissprot:YAFU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAFU_ECOLI inforesidue swissprot:YAFU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAFU_ECOLI octanol swissprot:YAFU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAFU_ECOLI pepcoil swissprot:YAFU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAFU_ECOLI pepdigest swissprot:YAFU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAFU_ECOLI pepinfo swissprot:YAFU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAFU_ECOLI pepnet swissprot:YAFU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAFU_ECOLI pepstats swissprot:YAFU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAFU_ECOLI pepwheel swissprot:YAFU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAFU_ECOLI pepwindow swissprot:YAFU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAFU_ECOLI sigcleave swissprot:YAFU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAFU_ECOLI ## Database ID URL or Descriptions # BioGrid 4260781 6 # CDD cd00383 trans_reg_C # DISRUPTION PHENOTYPE Loss of Pcad activity. {ECO:0000269|PubMed 1370290}. # EcoGene EG10133 cadC # FUNCTION CADC_ECOLI Required for Pcad induction, a promoter upstream of cadBA that is responsible for the pH-regulated expression of CadA and CadB. Probably acts as an activating transcription factor. {ECO 0000269|PubMed 1370290}. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0000160 phosphorelay signal transduction system; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IMP:EcoCyc. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005622 intracellular # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # Gene3D 1.25.40.10 -; 2. # INDUCTION Induction requires low pH plus exogenous lysine as sensed by LysP as well as EF-P for translation. This requirement is reduced as the number of consecutive Pro residues in the protein is decreased. {ECO:0000269|PubMed 23239623}. # InterPro IPR001867 OmpR/PhoB-type_DNA-bd # InterPro IPR011990 TPR-like_helical_dom # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR016032 Sig_transdc_resp-reg_C-effctor # KEGG_Brite ko03000 Transcription factors # Organism CADC_ECOLI Escherichia coli (strain K12) # PATRIC 32123833 VBIEscCol129921_4265 # PDB 3LY7 X-ray; 1.80 A; A=188-512 # PDB 3LY8 X-ray; 1.90 A; A=188-512 # PDB 3LY9 X-ray; 2.20 A; A=188-512 # PDB 3LYA X-ray; 2.30 A; A=188-512 # PIR C41968 C41968 # PROSITE PS51755 OMPR_PHOB # Pfam PF00486 Trans_reg_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CADC_ECOLI Transcriptional activator CadC # RefSeq NP_418557 NC_000913.3 # RefSeq WP_001187173 NZ_LN832404.1 # SIMILARITY Contains 1 OmpR/PhoB-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU01091}. # SMART SM00862 Trans_reg_C # SUBCELLULAR LOCATION CADC_ECOLI Cell membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. # SUPFAM SSF46894 SSF46894 # eggNOG COG3710 LUCA # eggNOG ENOG4108M3R Bacteria BLAST swissprot:CADC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CADC_ECOLI BioCyc ECOL316407:JW4094-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4094-MONOMER BioCyc EcoCyc:PD00436 http://biocyc.org/getid?id=EcoCyc:PD00436 COG COG3710 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3710 DIP DIP-9239N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9239N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.1228985 http://dx.doi.org/10.1126/science.1228985 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M67452 http://www.ebi.ac.uk/ena/data/view/M67452 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB0131 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0131 EcoGene EG10133 http://www.ecogene.org/geneInfo.php?eg_id=EG10133 EnsemblBacteria AAC77094 http://www.ensemblgenomes.org/id/AAC77094 EnsemblBacteria AAC77094 http://www.ensemblgenomes.org/id/AAC77094 EnsemblBacteria BAE78136 http://www.ensemblgenomes.org/id/BAE78136 EnsemblBacteria BAE78136 http://www.ensemblgenomes.org/id/BAE78136 EnsemblBacteria BAE78136 http://www.ensemblgenomes.org/id/BAE78136 EnsemblBacteria b4133 http://www.ensemblgenomes.org/id/b4133 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 1.25.40.10 http://www.cathdb.info/version/latest/superfamily/1.25.40.10 GeneID 948653 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948653 HOGENOM HOG000127085 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000127085&db=HOGENOM6 IntAct P23890 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P23890* InterPro IPR001867 http://www.ebi.ac.uk/interpro/entry/IPR001867 InterPro IPR011990 http://www.ebi.ac.uk/interpro/entry/IPR011990 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR016032 http://www.ebi.ac.uk/interpro/entry/IPR016032 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW4094 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4094 KEGG_Gene eco:b4133 http://www.genome.jp/dbget-bin/www_bget?eco:b4133 KEGG_Orthology KO:K03765 http://www.genome.jp/dbget-bin/www_bget?KO:K03765 OMA VPYLDNF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VPYLDNF PDB 3LY7 http://www.ebi.ac.uk/pdbe-srv/view/entry/3LY7 PDB 3LY8 http://www.ebi.ac.uk/pdbe-srv/view/entry/3LY8 PDB 3LY9 http://www.ebi.ac.uk/pdbe-srv/view/entry/3LY9 PDB 3LYA http://www.ebi.ac.uk/pdbe-srv/view/entry/3LYA PDBsum 3LY7 http://www.ebi.ac.uk/pdbsum/3LY7 PDBsum 3LY8 http://www.ebi.ac.uk/pdbsum/3LY8 PDBsum 3LY9 http://www.ebi.ac.uk/pdbsum/3LY9 PDBsum 3LYA http://www.ebi.ac.uk/pdbsum/3LYA PROSITE PS51755 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51755 PSORT swissprot:CADC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CADC_ECOLI PSORT-B swissprot:CADC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CADC_ECOLI PSORT2 swissprot:CADC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CADC_ECOLI Pfam PF00486 http://pfam.xfam.org/family/PF00486 Phobius swissprot:CADC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CADC_ECOLI ProteinModelPortal P23890 http://www.proteinmodelportal.org/query/uniprot/P23890 PubMed 1370290 http://www.ncbi.nlm.nih.gov/pubmed/1370290 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 23239623 http://www.ncbi.nlm.nih.gov/pubmed/23239623 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418557 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418557 RefSeq WP_001187173 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001187173 SMART SM00862 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00862 SMR P23890 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P23890 STRING 511145.b4133 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4133&targetmode=cogs STRING COG3710 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3710&targetmode=cogs SUPFAM SSF46894 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46894 UniProtKB CADC_ECOLI http://www.uniprot.org/uniprot/CADC_ECOLI UniProtKB-AC P23890 http://www.uniprot.org/uniprot/P23890 charge swissprot:CADC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CADC_ECOLI eggNOG COG3710 http://eggnogapi.embl.de/nog_data/html/tree/COG3710 eggNOG ENOG4108M3R http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108M3R epestfind swissprot:CADC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CADC_ECOLI garnier swissprot:CADC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CADC_ECOLI helixturnhelix swissprot:CADC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CADC_ECOLI hmoment swissprot:CADC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CADC_ECOLI iep swissprot:CADC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CADC_ECOLI inforesidue swissprot:CADC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CADC_ECOLI octanol swissprot:CADC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CADC_ECOLI pepcoil swissprot:CADC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CADC_ECOLI pepdigest swissprot:CADC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CADC_ECOLI pepinfo swissprot:CADC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CADC_ECOLI pepnet swissprot:CADC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CADC_ECOLI pepstats swissprot:CADC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CADC_ECOLI pepwheel swissprot:CADC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CADC_ECOLI pepwindow swissprot:CADC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CADC_ECOLI sigcleave swissprot:CADC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CADC_ECOLI ## Database ID URL or Descriptions # AltName FINO_ECOLI Conjugal transfer repressor # CAUTION In strain K12 / CR63, finO is interrupted by an IS3 element. {ECO 0000305}. # FUNCTION FINO_ECOLI One of the components on the FinOP fertility inhibition complex, which inhibits the expression of traJ gene, which in turn regulates the expression of some 20 transfer genes. The transfer genes are responsible for the process, called conjugal transfer, in which DNA is transmitted from one bacterial host to another. RNA-binding that interacts with the traJ mRNA and its antisense RNA, finP, stabilizing finP against endonucleolytic degradation and facilitating sense-antisense RNA recognition. # GO_function GO:0003723 RNA binding; IEA:UniProtKB-KW. # GO_process GO:0000746 conjugation; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_function GO:0003723 RNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.1710.10 -; 1. # InterPro IPR016103 ProQ/FinO # InterPro IPR021065 Fertility_inhibition_FinO_N # Organism FINO_ECOLI Escherichia coli (strain K12) # PIR JQ1339 JQ1339 # Pfam PF04352 ProQ # Pfam PF12602 FinO_N # RecName FINO_ECOLI Fertility inhibition protein # SIMILARITY Belongs to the FinO family. {ECO 0000305}. # SMART SM00945 ProQ # SUPFAM SSF48657 SSF48657 BLAST swissprot:FINO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FINO_ECOLI DOI 10.1016/0022-2836(90)90145-C http://dx.doi.org/10.1016/0022-2836(90)90145-C DOI 10.1016/0378-1119(91)90469-R http://dx.doi.org/10.1016/0378-1119(91)90469-R EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL M38047 http://www.ebi.ac.uk/ena/data/view/M38047 EMBL U01159 http://www.ebi.ac.uk/ena/data/view/U01159 EMBL U50705 http://www.ebi.ac.uk/ena/data/view/U50705 EMBL X57429 http://www.ebi.ac.uk/ena/data/view/X57429 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_process GO:0000746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000746 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.1710.10 http://www.cathdb.info/version/latest/superfamily/1.10.1710.10 InterPro IPR016103 http://www.ebi.ac.uk/interpro/entry/IPR016103 InterPro IPR021065 http://www.ebi.ac.uk/interpro/entry/IPR021065 PSORT swissprot:FINO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FINO_ECOLI PSORT-B swissprot:FINO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FINO_ECOLI PSORT2 swissprot:FINO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FINO_ECOLI Pfam PF04352 http://pfam.xfam.org/family/PF04352 Pfam PF12602 http://pfam.xfam.org/family/PF12602 Phobius swissprot:FINO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FINO_ECOLI ProteinModelPortal P22707 http://www.proteinmodelportal.org/query/uniprot/P22707 PubMed 1916281 http://www.ncbi.nlm.nih.gov/pubmed/1916281 PubMed 2164585 http://www.ncbi.nlm.nih.gov/pubmed/2164585 PubMed 7915817 http://www.ncbi.nlm.nih.gov/pubmed/7915817 PubMed 8807284 http://www.ncbi.nlm.nih.gov/pubmed/8807284 SMART SM00945 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00945 SMR P22707 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P22707 SUPFAM SSF48657 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48657 UniProtKB FINO_ECOLI http://www.uniprot.org/uniprot/FINO_ECOLI UniProtKB-AC P22707 http://www.uniprot.org/uniprot/P22707 charge swissprot:FINO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FINO_ECOLI epestfind swissprot:FINO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FINO_ECOLI garnier swissprot:FINO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FINO_ECOLI helixturnhelix swissprot:FINO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FINO_ECOLI hmoment swissprot:FINO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FINO_ECOLI iep swissprot:FINO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FINO_ECOLI inforesidue swissprot:FINO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FINO_ECOLI octanol swissprot:FINO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FINO_ECOLI pepcoil swissprot:FINO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FINO_ECOLI pepdigest swissprot:FINO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FINO_ECOLI pepinfo swissprot:FINO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FINO_ECOLI pepnet swissprot:FINO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FINO_ECOLI pepstats swissprot:FINO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FINO_ECOLI pepwheel swissprot:FINO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FINO_ECOLI pepwindow swissprot:FINO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FINO_ECOLI sigcleave swissprot:FINO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FINO_ECOLI ## Database ID URL or Descriptions # BioGrid 4262852 4 # EcoGene EG14336 ymfR # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR020297 YmfR # Organism YMFR_ECOLI Escherichia coli (strain K12) # PATRIC 32117537 VBIEscCol129921_1191 # PIR C64860 C64860 # ProDom PD052744 Uncharacterised_YmfR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YMFR_ECOLI Uncharacterized protein YmfR # RefSeq NP_415668 NC_000913.3 # RefSeq WP_000605606 NZ_CP010440.1 # SUBCELLULAR LOCATION YMFR_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. BLAST swissprot:YMFR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YMFR_ECOLI BioCyc ECOL316407:JW1136-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1136-MONOMER BioCyc EcoCyc:G6594-MONOMER http://biocyc.org/getid?id=EcoCyc:G6594-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4082 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4082 EcoGene EG14336 http://www.ecogene.org/geneInfo.php?eg_id=EG14336 EnsemblBacteria AAC74234 http://www.ensemblgenomes.org/id/AAC74234 EnsemblBacteria AAC74234 http://www.ensemblgenomes.org/id/AAC74234 EnsemblBacteria BAA35976 http://www.ensemblgenomes.org/id/BAA35976 EnsemblBacteria BAA35976 http://www.ensemblgenomes.org/id/BAA35976 EnsemblBacteria BAA35976 http://www.ensemblgenomes.org/id/BAA35976 EnsemblBacteria b1150 http://www.ensemblgenomes.org/id/b1150 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 945700 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945700 HOGENOM HOG000028806 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000028806&db=HOGENOM6 InterPro IPR020297 http://www.ebi.ac.uk/interpro/entry/IPR020297 KEGG_Gene ecj:JW1136 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1136 KEGG_Gene eco:b1150 http://www.genome.jp/dbget-bin/www_bget?eco:b1150 OMA QIYEPAG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QIYEPAG PSORT swissprot:YMFR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YMFR_ECOLI PSORT-B swissprot:YMFR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YMFR_ECOLI PSORT2 swissprot:YMFR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YMFR_ECOLI Phobius swissprot:YMFR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YMFR_ECOLI ProteinModelPortal P75979 http://www.proteinmodelportal.org/query/uniprot/P75979 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415668 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415668 RefSeq WP_000605606 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000605606 STRING 511145.b1150 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1150&targetmode=cogs UniProtKB YMFR_ECOLI http://www.uniprot.org/uniprot/YMFR_ECOLI UniProtKB-AC P75979 http://www.uniprot.org/uniprot/P75979 charge swissprot:YMFR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YMFR_ECOLI epestfind swissprot:YMFR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YMFR_ECOLI garnier swissprot:YMFR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YMFR_ECOLI helixturnhelix swissprot:YMFR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YMFR_ECOLI hmoment swissprot:YMFR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YMFR_ECOLI iep swissprot:YMFR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YMFR_ECOLI inforesidue swissprot:YMFR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YMFR_ECOLI octanol swissprot:YMFR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YMFR_ECOLI pepcoil swissprot:YMFR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YMFR_ECOLI pepdigest swissprot:YMFR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YMFR_ECOLI pepinfo swissprot:YMFR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YMFR_ECOLI pepnet swissprot:YMFR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YMFR_ECOLI pepstats swissprot:YMFR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YMFR_ECOLI pepwheel swissprot:YMFR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YMFR_ECOLI pepwindow swissprot:YMFR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YMFR_ECOLI sigcleave swissprot:YMFR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YMFR_ECOLI ## Database ID URL or Descriptions # BioGrid 4261506 14 # CDD cd06174 MFS # EcoGene EG11343 mdtG # FUNCTION MDTG_ECOLI Confers resistance to fosfomycin and deoxycholate. {ECO 0000269|PubMed 11566977}. # GO_component GO:0005887 integral component of plasma membrane; IEA:UniProtKB-HAMAP. # GO_component GO:0016021 integral component of membrane; IBA:GO_Central. # GO_function GO:0005215 transporter activity; IBA:GO_Central. # GO_function GO:0022857 transmembrane transporter activity; IEA:UniProtKB-HAMAP. # GO_process GO:0006855 drug transmembrane transport; IMP:EcoCyc. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0055085 transmembrane transport # HAMAP MF_01528 MFS_MdtG # InterPro IPR001958 Tet-R_TetA/multi-R_MdtG # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # InterPro IPR023692 Mutidrug-R_MdtG # KEGG_Brite ko02000 Transporters # Organism MDTG_ECOLI Escherichia coli (strain K12) # PATRIC 32117343 VBIEscCol129921_1094 # PIR B42290 B42290 # PRINTS PR01035 TCRTETA # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MDTG_ECOLI Multidrug resistance protein MdtG # RefSeq NP_415571 NC_000913.3 # RefSeq WP_000074172 NZ_LN832404.1 # SIMILARITY Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION MDTG_ECOLI Cell inner membrane {ECO 0000305}; Multi- pass membrane protein {ECO 0000305}. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.2.20 the major facilitator superfamily (mfs) # eggNOG ENOG4105C6X Bacteria # eggNOG ENOG410ZVCH LUCA BLAST swissprot:MDTG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MDTG_ECOLI BioCyc ECOL316407:JW1040-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1040-MONOMER BioCyc EcoCyc:YCEE-MONOMER http://biocyc.org/getid?id=EcoCyc:YCEE-MONOMER COG COG0477 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0477 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.183.20.5803-5812.2001 http://dx.doi.org/10.1128/JB.183.20.5803-5812.2001 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X59939 http://www.ebi.ac.uk/ena/data/view/X59939 EchoBASE EB1319 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1319 EcoGene EG11343 http://www.ecogene.org/geneInfo.php?eg_id=EG11343 EnsemblBacteria AAC74137 http://www.ensemblgenomes.org/id/AAC74137 EnsemblBacteria AAC74137 http://www.ensemblgenomes.org/id/AAC74137 EnsemblBacteria BAA35851 http://www.ensemblgenomes.org/id/BAA35851 EnsemblBacteria BAA35851 http://www.ensemblgenomes.org/id/BAA35851 EnsemblBacteria BAA35851 http://www.ensemblgenomes.org/id/BAA35851 EnsemblBacteria b1053 http://www.ensemblgenomes.org/id/b1053 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GO_process GO:0006855 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006855 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 945627 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945627 HAMAP MF_01528 http://hamap.expasy.org/unirule/MF_01528 HOGENOM HOG000066093 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000066093&db=HOGENOM6 InParanoid P25744 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P25744 InterPro IPR001958 http://www.ebi.ac.uk/interpro/entry/IPR001958 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 InterPro IPR023692 http://www.ebi.ac.uk/interpro/entry/IPR023692 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1040 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1040 KEGG_Gene eco:b1053 http://www.genome.jp/dbget-bin/www_bget?eco:b1053 KEGG_Orthology KO:K08161 http://www.genome.jp/dbget-bin/www_bget?KO:K08161 OMA SYGFRTV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SYGFRTV PRINTS PR01035 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01035 PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:MDTG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MDTG_ECOLI PSORT-B swissprot:MDTG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MDTG_ECOLI PSORT2 swissprot:MDTG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MDTG_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:MDTG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MDTG_ECOLI PhylomeDB P25744 http://phylomedb.org/?seqid=P25744 ProteinModelPortal P25744 http://www.proteinmodelportal.org/query/uniprot/P25744 PubMed 11566977 http://www.ncbi.nlm.nih.gov/pubmed/11566977 PubMed 1537791 http://www.ncbi.nlm.nih.gov/pubmed/1537791 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415571 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415571 RefSeq WP_000074172 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000074172 STRING 511145.b1053 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1053&targetmode=cogs STRING COG0477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0477&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.2.20 http://www.tcdb.org/search/result.php?tc=2.A.1.2.20 UniProtKB MDTG_ECOLI http://www.uniprot.org/uniprot/MDTG_ECOLI UniProtKB-AC P25744 http://www.uniprot.org/uniprot/P25744 charge swissprot:MDTG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MDTG_ECOLI eggNOG ENOG4105C6X http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C6X eggNOG ENOG410ZVCH http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZVCH epestfind swissprot:MDTG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MDTG_ECOLI garnier swissprot:MDTG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MDTG_ECOLI helixturnhelix swissprot:MDTG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MDTG_ECOLI hmoment swissprot:MDTG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MDTG_ECOLI iep swissprot:MDTG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MDTG_ECOLI inforesidue swissprot:MDTG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MDTG_ECOLI octanol swissprot:MDTG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MDTG_ECOLI pepcoil swissprot:MDTG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MDTG_ECOLI pepdigest swissprot:MDTG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MDTG_ECOLI pepinfo swissprot:MDTG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MDTG_ECOLI pepnet swissprot:MDTG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MDTG_ECOLI pepstats swissprot:MDTG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MDTG_ECOLI pepwheel swissprot:MDTG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MDTG_ECOLI pepwindow swissprot:MDTG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MDTG_ECOLI sigcleave swissprot:MDTG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MDTG_ECOLI ## Database ID URL or Descriptions # AltName GLNE_ECOLI Glutamine-synthetase adenylyltransferase # AltName GLNE_ECOLI [Glutamate--ammonia-ligase] adenylyltransferase # BIOPHYSICOCHEMICAL PROPERTIES GLNE_ECOLI Kinetic parameters KM=5 uM for [L-glutamate ammonia ligase (ADP-forming)] {ECO 0000269|PubMed 4920894}; KM=150 uM for ATP {ECO 0000269|PubMed 4920894}; pH dependence Optimum pH is 7.6. {ECO 0000269|PubMed 4920894}; # BRENDA 2.7.7.42 2026 # BioGrid 4261515 4 # CATALYTIC ACTIVITY ATP + [glutamine synthetase]-L-tyrosine = diphosphate + [glutamine synthetase]-O(4)-(5'-adenylyl)-L- tyrosine. {ECO:0000269|PubMed 4920894}. # COFACTOR GLNE_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 4920894}; # EcoGene EG11602 glnE # FUNCTION GLNE_ECOLI Adenylation and deadenylation of glutamate--ammonia ligase. {ECO 0000269|PubMed 8412694}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0008882 [glutamate-ammonia-ligase] adenylyltransferase activity; IBA:GO_Central. # GO_process GO:0000820 regulation of glutamine family amino acid metabolic process; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # HAMAP MF_00802 GlnE # IntAct P30870 2 # InterPro IPR005190 GlnE_rpt_dom # InterPro IPR013546 PII_UdlTrfase/GS_AdlTrfase # InterPro IPR023057 GlnE # KEGG_Brite ko01000 Enzymes # Organism GLNE_ECOLI Escherichia coli (strain K12) # PATRIC 32121518 VBIEscCol129921_3146 # PDB 1V4A X-ray; 2.00 A; A=1-440 # PDB 3K7D X-ray; 2.40 A; A/B=449-946 # PIR C65093 C65093 # Pfam PF03710 GlnE; 2 # Pfam PF08335 GlnD_UR_UTase; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLNE_ECOLI Glutamate-ammonia-ligase adenylyltransferase # RefSeq NP_417525 NC_000913.3 # RefSeq WP_001301081 NZ_LN832404.1 # SIMILARITY Belongs to the GlnE family. {ECO 0000305}. # SUBUNIT Monomer. {ECO:0000269|PubMed 4920894}. # eggNOG COG1391 LUCA # eggNOG ENOG4105CE6 Bacteria BLAST swissprot:GLNE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLNE_ECOLI BioCyc ECOL316407:JW3025-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3025-MONOMER BioCyc EcoCyc:GLNE-MONOMER http://biocyc.org/getid?id=EcoCyc:GLNE-MONOMER BioCyc MetaCyc:GLNE-MONOMER http://biocyc.org/getid?id=MetaCyc:GLNE-MONOMER COG COG1391 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1391 DIP DIP-9780N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9780N DOI 10.1016/j.str.2004.02.029 http://dx.doi.org/10.1016/j.str.2004.02.029 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1993.tb01706.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb01706.x DOI 10.1111/j.1432-1033.1970.tb00320.x http://dx.doi.org/10.1111/j.1432-1033.1970.tb00320.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.7.42 {ECO:0000269|PubMed:4920894} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.42 {ECO:0000269|PubMed:4920894} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL Z21844 http://www.ebi.ac.uk/ena/data/view/Z21844 ENZYME 2.7.7.42 {ECO:0000269|PubMed:4920894} http://enzyme.expasy.org/EC/2.7.7.42 {ECO:0000269|PubMed:4920894} EchoBASE EB1559 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1559 EcoGene EG11602 http://www.ecogene.org/geneInfo.php?eg_id=EG11602 EnsemblBacteria AAC76089 http://www.ensemblgenomes.org/id/AAC76089 EnsemblBacteria AAC76089 http://www.ensemblgenomes.org/id/AAC76089 EnsemblBacteria BAE77104 http://www.ensemblgenomes.org/id/BAE77104 EnsemblBacteria BAE77104 http://www.ensemblgenomes.org/id/BAE77104 EnsemblBacteria BAE77104 http://www.ensemblgenomes.org/id/BAE77104 EnsemblBacteria b3053 http://www.ensemblgenomes.org/id/b3053 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008882 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008882 GO_process GO:0000820 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000820 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 947552 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947552 HAMAP MF_00802 http://hamap.expasy.org/unirule/MF_00802 HOGENOM HOG000256491 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000256491&db=HOGENOM6 InParanoid P30870 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30870 IntAct P30870 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P30870* IntEnz 2.7.7.42 {ECO:0000269|PubMed:4920894} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.42 {ECO:0000269|PubMed:4920894} InterPro IPR005190 http://www.ebi.ac.uk/interpro/entry/IPR005190 InterPro IPR013546 http://www.ebi.ac.uk/interpro/entry/IPR013546 InterPro IPR023057 http://www.ebi.ac.uk/interpro/entry/IPR023057 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3025 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3025 KEGG_Gene eco:b3053 http://www.genome.jp/dbget-bin/www_bget?eco:b3053 KEGG_Orthology KO:K00982 http://www.genome.jp/dbget-bin/www_bget?KO:K00982 OMA TWERIAW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TWERIAW PDB 1V4A http://www.ebi.ac.uk/pdbe-srv/view/entry/1V4A PDB 3K7D http://www.ebi.ac.uk/pdbe-srv/view/entry/3K7D PDBsum 1V4A http://www.ebi.ac.uk/pdbsum/1V4A PDBsum 3K7D http://www.ebi.ac.uk/pdbsum/3K7D PSORT swissprot:GLNE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLNE_ECOLI PSORT-B swissprot:GLNE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLNE_ECOLI PSORT2 swissprot:GLNE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLNE_ECOLI Pfam PF03710 http://pfam.xfam.org/family/PF03710 Pfam PF08335 http://pfam.xfam.org/family/PF08335 Phobius swissprot:GLNE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLNE_ECOLI PhylomeDB P30870 http://phylomedb.org/?seqid=P30870 ProteinModelPortal P30870 http://www.proteinmodelportal.org/query/uniprot/P30870 PubMed 15130478 http://www.ncbi.nlm.nih.gov/pubmed/15130478 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 4920894 http://www.ncbi.nlm.nih.gov/pubmed/4920894 PubMed 8412694 http://www.ncbi.nlm.nih.gov/pubmed/8412694 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417525 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417525 RefSeq WP_001301081 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001301081 SMR P30870 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P30870 STRING 511145.b3053 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3053&targetmode=cogs STRING COG1391 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1391&targetmode=cogs UniProtKB GLNE_ECOLI http://www.uniprot.org/uniprot/GLNE_ECOLI UniProtKB-AC P30870 http://www.uniprot.org/uniprot/P30870 charge swissprot:GLNE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLNE_ECOLI eggNOG COG1391 http://eggnogapi.embl.de/nog_data/html/tree/COG1391 eggNOG ENOG4105CE6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CE6 epestfind swissprot:GLNE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLNE_ECOLI garnier swissprot:GLNE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLNE_ECOLI helixturnhelix swissprot:GLNE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLNE_ECOLI hmoment swissprot:GLNE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLNE_ECOLI iep swissprot:GLNE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLNE_ECOLI inforesidue swissprot:GLNE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLNE_ECOLI octanol swissprot:GLNE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLNE_ECOLI pepcoil swissprot:GLNE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLNE_ECOLI pepdigest swissprot:GLNE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLNE_ECOLI pepinfo swissprot:GLNE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLNE_ECOLI pepnet swissprot:GLNE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLNE_ECOLI pepstats swissprot:GLNE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLNE_ECOLI pepwheel swissprot:GLNE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLNE_ECOLI pepwindow swissprot:GLNE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLNE_ECOLI sigcleave swissprot:GLNE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLNE_ECOLI ## Database ID URL or Descriptions # AltName UXUB_ECOLI Fructuronate reductase # BioGrid 4260999 6 # CATALYTIC ACTIVITY UXUB_ECOLI D-mannonate + NAD(+) = D-fructuronate + NADH. # EcoGene EG20248 uxuB # GO_function GO:0008866 fructuronate reductase activity; IMP:CACAO. # GO_function GO:0050662 coenzyme binding; IEA:InterPro. # GO_process GO:0019594 mannitol metabolic process; IEA:InterPro. # GO_process GO:0042840 D-glucuronate catabolic process; IMP:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.1040.10 -; 1. # Gene3D 3.40.50.720 -; 1. # IntAct P39160 3 # InterPro IPR000669 Mannitol_DH # InterPro IPR008927 6-PGluconate_DH_C-like # InterPro IPR013118 Mannitol_DH_C # InterPro IPR013131 Mannitol_DH_N # InterPro IPR013328 6PGD_dom_2 # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR023027 Mannitol_DH_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00040 Pentose and glucuronate interconversions # Organism UXUB_ECOLI Escherichia coli (strain K12) # PATHWAY UXUB_ECOLI Carbohydrate metabolism; pentose and glucuronate interconversion. # PATRIC 32124242 VBIEscCol129921_4464 # PIR S56548 S56548 # PRINTS PR00084 MTLDHDRGNASE # PROSITE PS00974 MANNITOL_DHGENASE # Pfam PF01232 Mannitol_dh # Pfam PF08125 Mannitol_dh_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UXUB_ECOLI D-mannonate oxidoreductase # RefSeq NP_418743 NC_000913.3 # RefSeq WP_000208205 NZ_LN832404.1 # SIMILARITY Belongs to the mannitol dehydrogenase family. UxuB subfamily. {ECO 0000305}. # SUPFAM SSF48179 SSF48179 # SUPFAM SSF51735 SSF51735 # eggNOG COG0246 LUCA # eggNOG ENOG4105DEI Bacteria BLAST swissprot:UXUB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UXUB_ECOLI BioCyc ECOL316407:JW4286-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4286-MONOMER BioCyc EcoCyc:MANNONOXIDOREDUCT-MONOMER http://biocyc.org/getid?id=EcoCyc:MANNONOXIDOREDUCT-MONOMER BioCyc MetaCyc:MANNONOXIDOREDUCT-MONOMER http://biocyc.org/getid?id=MetaCyc:MANNONOXIDOREDUCT-MONOMER COG COG0246 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0246 DIP DIP-11109N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11109N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.57 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.57 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D13329 http://www.ebi.ac.uk/ena/data/view/D13329 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 1.1.1.57 http://enzyme.expasy.org/EC/1.1.1.57 EchoBASE EB4150 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4150 EcoGene EG20248 http://www.ecogene.org/geneInfo.php?eg_id=EG20248 EnsemblBacteria AAC77279 http://www.ensemblgenomes.org/id/AAC77279 EnsemblBacteria AAC77279 http://www.ensemblgenomes.org/id/AAC77279 EnsemblBacteria BAE78316 http://www.ensemblgenomes.org/id/BAE78316 EnsemblBacteria BAE78316 http://www.ensemblgenomes.org/id/BAE78316 EnsemblBacteria BAE78316 http://www.ensemblgenomes.org/id/BAE78316 EnsemblBacteria b4323 http://www.ensemblgenomes.org/id/b4323 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008866 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008866 GO_function GO:0050662 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050662 GO_process GO:0019594 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019594 GO_process GO:0042840 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042840 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.1040.10 http://www.cathdb.info/version/latest/superfamily/1.10.1040.10 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 946795 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946795 HOGENOM HOG000202982 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000202982&db=HOGENOM6 InParanoid P39160 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39160 IntAct P39160 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39160* IntEnz 1.1.1.57 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.57 InterPro IPR000669 http://www.ebi.ac.uk/interpro/entry/IPR000669 InterPro IPR008927 http://www.ebi.ac.uk/interpro/entry/IPR008927 InterPro IPR013118 http://www.ebi.ac.uk/interpro/entry/IPR013118 InterPro IPR013131 http://www.ebi.ac.uk/interpro/entry/IPR013131 InterPro IPR013328 http://www.ebi.ac.uk/interpro/entry/IPR013328 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR023027 http://www.ebi.ac.uk/interpro/entry/IPR023027 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4286 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4286 KEGG_Gene eco:b4323 http://www.genome.jp/dbget-bin/www_bget?eco:b4323 KEGG_Orthology KO:K00040 http://www.genome.jp/dbget-bin/www_bget?KO:K00040 KEGG_Pathway ko00040 http://www.genome.jp/kegg-bin/show_pathway?ko00040 KEGG_Reaction rn:R02454 http://www.genome.jp/dbget-bin/www_bget?rn:R02454 OMA CHNPATG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CHNPATG PRINTS PR00084 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00084 PROSITE PS00974 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00974 PSORT swissprot:UXUB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UXUB_ECOLI PSORT-B swissprot:UXUB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UXUB_ECOLI PSORT2 swissprot:UXUB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UXUB_ECOLI Pfam PF01232 http://pfam.xfam.org/family/PF01232 Pfam PF08125 http://pfam.xfam.org/family/PF08125 Phobius swissprot:UXUB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UXUB_ECOLI PhylomeDB P39160 http://phylomedb.org/?seqid=P39160 ProteinModelPortal P39160 http://www.proteinmodelportal.org/query/uniprot/P39160 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418743 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418743 RefSeq WP_000208205 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000208205 SMR P39160 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39160 STRING 511145.b4323 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4323&targetmode=cogs STRING COG0246 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0246&targetmode=cogs SUPFAM SSF48179 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48179 SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB UXUB_ECOLI http://www.uniprot.org/uniprot/UXUB_ECOLI UniProtKB-AC P39160 http://www.uniprot.org/uniprot/P39160 charge swissprot:UXUB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UXUB_ECOLI eggNOG COG0246 http://eggnogapi.embl.de/nog_data/html/tree/COG0246 eggNOG ENOG4105DEI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DEI epestfind swissprot:UXUB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UXUB_ECOLI garnier swissprot:UXUB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UXUB_ECOLI helixturnhelix swissprot:UXUB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UXUB_ECOLI hmoment swissprot:UXUB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UXUB_ECOLI iep swissprot:UXUB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UXUB_ECOLI inforesidue swissprot:UXUB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UXUB_ECOLI octanol swissprot:UXUB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UXUB_ECOLI pepcoil swissprot:UXUB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UXUB_ECOLI pepdigest swissprot:UXUB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UXUB_ECOLI pepinfo swissprot:UXUB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UXUB_ECOLI pepnet swissprot:UXUB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UXUB_ECOLI pepstats swissprot:UXUB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UXUB_ECOLI pepwheel swissprot:UXUB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UXUB_ECOLI pepwindow swissprot:UXUB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UXUB_ECOLI sigcleave swissprot:UXUB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UXUB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260254 85 # EcoGene EG11038 tus # FUNCTION TUS_ECOLI Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0043565 sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0006274 DNA replication termination; IDA:EcoCyc. # GO_process GO:0071807 replication fork arrest involved in DNA replication termination; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # Gene3D 3.50.14.10 -; 2. # HAMAP MF_00483 Rep_term_Tus # IntAct P16525 2 # InterPro IPR008865 DNA_replication_term_site-bd # KEGG_Brite ko03032 DNA replication proteins # Organism TUS_ECOLI Escherichia coli (strain K12) # PATRIC 32118522 VBIEscCol129921_1681 # PDB 1ECR X-ray; 2.70 A; A=1-309 # PDB 1SUT NMR; -; A=223-244 # PDB 2EWJ X-ray; 2.70 A; A=1-309 # PDB 2I05 X-ray; 2.60 A; A=1-309 # PDB 2I06 X-ray; 2.20 A; A=1-309 # PDB 4XR0 X-ray; 2.80 A; A=1-309 # PDB 4XR1 X-ray; 2.40 A; A=1-309 # PDB 4XR2 X-ray; 2.35 A; A=1-309 # PDB 4XR3 X-ray; 2.70 A; A=1-309 # PIR B32161 DNECTS # Pfam PF05472 Ter # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DNA replication terminus site-binding protein {ECO:0000255|HAMAP-Rule MF_00483} # RefSeq NP_416127 NC_000913.3 # RefSeq WP_000135181 NZ_LN832404.1 # SIMILARITY Belongs to the Tus family. {ECO:0000255|HAMAP- Rule MF_00483}. # SUBCELLULAR LOCATION TUS_ECOLI Cytoplasm. # SUBUNIT TUS_ECOLI Monomer. # SUPFAM SSF56596 SSF56596 # TIGRFAMs TIGR02648 rep_term_tus # eggNOG ENOG4105KR1 Bacteria # eggNOG ENOG410XSWR LUCA BLAST swissprot:TUS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TUS_ECOLI BioCyc ECOL316407:JW1602-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1602-MONOMER BioCyc EcoCyc:EG11038-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11038-MONOMER DIP DIP-11056N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11056N DOI 10.1021/bi952419l http://dx.doi.org/10.1021/bi952419l DOI 10.1038/383598a0 http://dx.doi.org/10.1038/383598a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2370547 http://dx.doi.org/10.1042/bj2370547 DOI 10.1073/pnas.86.5.1593 http://dx.doi.org/10.1073/pnas.86.5.1593 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D90037 http://www.ebi.ac.uk/ena/data/view/D90037 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U41101 http://www.ebi.ac.uk/ena/data/view/U41101 EMBL X04065 http://www.ebi.ac.uk/ena/data/view/X04065 EchoBASE EB1031 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1031 EcoGene EG11038 http://www.ecogene.org/geneInfo.php?eg_id=EG11038 EnsemblBacteria AAC74682 http://www.ensemblgenomes.org/id/AAC74682 EnsemblBacteria AAC74682 http://www.ensemblgenomes.org/id/AAC74682 EnsemblBacteria BAA15348 http://www.ensemblgenomes.org/id/BAA15348 EnsemblBacteria BAA15348 http://www.ensemblgenomes.org/id/BAA15348 EnsemblBacteria BAA15348 http://www.ensemblgenomes.org/id/BAA15348 EnsemblBacteria b1610 http://www.ensemblgenomes.org/id/b1610 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006274 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006274 GO_process GO:0071807 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071807 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 Gene3D 3.50.14.10 http://www.cathdb.info/version/latest/superfamily/3.50.14.10 GeneID 945135 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945135 HAMAP MF_00483 http://hamap.expasy.org/unirule/MF_00483 HOGENOM HOG000280323 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000280323&db=HOGENOM6 IntAct P16525 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P16525* InterPro IPR008865 http://www.ebi.ac.uk/interpro/entry/IPR008865 KEGG_Brite ko03032 http://www.genome.jp/dbget-bin/www_bget?ko03032 KEGG_Gene ecj:JW1602 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1602 KEGG_Gene eco:b1610 http://www.genome.jp/dbget-bin/www_bget?eco:b1610 KEGG_Orthology KO:K10748 http://www.genome.jp/dbget-bin/www_bget?KO:K10748 MINT MINT-584635 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-584635 OMA QVQYACP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QVQYACP PDB 1ECR http://www.ebi.ac.uk/pdbe-srv/view/entry/1ECR PDB 1SUT http://www.ebi.ac.uk/pdbe-srv/view/entry/1SUT PDB 2EWJ http://www.ebi.ac.uk/pdbe-srv/view/entry/2EWJ PDB 2I05 http://www.ebi.ac.uk/pdbe-srv/view/entry/2I05 PDB 2I06 http://www.ebi.ac.uk/pdbe-srv/view/entry/2I06 PDB 4XR0 http://www.ebi.ac.uk/pdbe-srv/view/entry/4XR0 PDB 4XR1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4XR1 PDB 4XR2 http://www.ebi.ac.uk/pdbe-srv/view/entry/4XR2 PDB 4XR3 http://www.ebi.ac.uk/pdbe-srv/view/entry/4XR3 PDBsum 1ECR http://www.ebi.ac.uk/pdbsum/1ECR PDBsum 1SUT http://www.ebi.ac.uk/pdbsum/1SUT PDBsum 2EWJ http://www.ebi.ac.uk/pdbsum/2EWJ PDBsum 2I05 http://www.ebi.ac.uk/pdbsum/2I05 PDBsum 2I06 http://www.ebi.ac.uk/pdbsum/2I06 PDBsum 4XR0 http://www.ebi.ac.uk/pdbsum/4XR0 PDBsum 4XR1 http://www.ebi.ac.uk/pdbsum/4XR1 PDBsum 4XR2 http://www.ebi.ac.uk/pdbsum/4XR2 PDBsum 4XR3 http://www.ebi.ac.uk/pdbsum/4XR3 PSORT swissprot:TUS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TUS_ECOLI PSORT-B swissprot:TUS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TUS_ECOLI PSORT2 swissprot:TUS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TUS_ECOLI Pfam PF05472 http://pfam.xfam.org/family/PF05472 Phobius swissprot:TUS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TUS_ECOLI ProteinModelPortal P16525 http://www.proteinmodelportal.org/query/uniprot/P16525 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2646639 http://www.ncbi.nlm.nih.gov/pubmed/2646639 PubMed 2687269 http://www.ncbi.nlm.nih.gov/pubmed/2687269 PubMed 3541901 http://www.ncbi.nlm.nih.gov/pubmed/3541901 PubMed 8547250 http://www.ncbi.nlm.nih.gov/pubmed/8547250 PubMed 8857533 http://www.ncbi.nlm.nih.gov/pubmed/8857533 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416127 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416127 RefSeq WP_000135181 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000135181 SMR P16525 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P16525 STRING 511145.b1610 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1610&targetmode=cogs SUPFAM SSF56596 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56596 TIGRFAMs TIGR02648 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02648 UniProtKB TUS_ECOLI http://www.uniprot.org/uniprot/TUS_ECOLI UniProtKB-AC P16525 http://www.uniprot.org/uniprot/P16525 charge swissprot:TUS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TUS_ECOLI eggNOG ENOG4105KR1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KR1 eggNOG ENOG410XSWR http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XSWR epestfind swissprot:TUS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TUS_ECOLI garnier swissprot:TUS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TUS_ECOLI helixturnhelix swissprot:TUS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TUS_ECOLI hmoment swissprot:TUS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TUS_ECOLI iep swissprot:TUS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TUS_ECOLI inforesidue swissprot:TUS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TUS_ECOLI octanol swissprot:TUS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TUS_ECOLI pepcoil swissprot:TUS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TUS_ECOLI pepdigest swissprot:TUS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TUS_ECOLI pepinfo swissprot:TUS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TUS_ECOLI pepnet swissprot:TUS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TUS_ECOLI pepstats swissprot:TUS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TUS_ECOLI pepwheel swissprot:TUS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TUS_ECOLI pepwindow swissprot:TUS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TUS_ECOLI sigcleave swissprot:TUS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TUS_ECOLI ## Database ID URL or Descriptions # AltName YIDC_ECOLI Foldase YidC # AltName YIDC_ECOLI Inner membrane protein YidC # AltName YIDC_ECOLI Membrane integrase YidC # AltName YIDC_ECOLI Oxa1Ec # BioGrid 4261511 225 # DISRUPTION PHENOTYPE YIDC_ECOLI Lethality. Upon depletion experiments insertion of Sec translocase-independent integral membrane proteins ceases. Translocation of Sec-dependent protein decreases to a lesser extent. Also leads to decreased targeting and/or translocation of Lpp and BRP lipoproteins. Both spoIIIJ and yqjG of B.subtilis functionally complement yidC depletion, whereas Streptococcus mutans yidC1 and yidC2 only partially complement depletion. {ECO 0000269|PubMed 10949305, ECO 0000269|PubMed 11415986, ECO 0000269|PubMed 15067017, ECO 0000269|PubMed 21778229}. # DOMAIN YIDC_ECOLI Most of the large periplasmic domain (residues 24-264) is not required for either Sec-dependent or Sec-independent protein insertion. However, residues 265-346, the C-terminal part of the large periplasmic domain, are required for both Sec-dependent and Sec-independent protein insertion. # EcoGene EG11197 yidC # FUNCTION YIDC_ECOLI Inner membrane protein required for the insertion and/or proper folding and/or complex formation of integral inner membrane proteins. Involved in integration of membrane proteins that insert dependently and independently of the Sec translocase complex, as well as at least 2 lipoproteins. Its own insertion requires SRP and is Sec translocase-dependent. Essential for the integration of Sec-dependent subunit a of the F(0)ATP synthase, FtsQ and SecE proteins and for Sec-independent subunit c of the F(0)ATP synthase, M13 phage procoat and the N-terminus of leader peptidase Lep. Probably interacts directly with Sec-independent substrates. Sec-dependent protein FtsQ interacts first with SecY then subsequently with YidC. Sec-dependent LacY and MalF require YidC to acquire tertiary structure and stability, a chaperone-like function, but not for membrane insertion. Stable maltose transport copmplex formation (MalFGK(2)) also requires YidC. Partially complements a Streptococcus mutans yidC2 disruption mutant. {ECO 0000269|PubMed 10675323, ECO 0000269|PubMed 10949305, ECO 0000269|PubMed 12724529, ECO 0000269|PubMed 12950181, ECO 0000269|PubMed 15067017, ECO 0000269|PubMed 15140892, ECO 0000269|PubMed 17073462, ECO 0000269|PubMed 18456666}. # GO_component GO:0005886 plasma membrane; IDA:UniProtKB. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IDA:UniProtKB. # GO_function GO:0032977 membrane insertase activity; IDA:EcoCyc. # GO_process GO:0006457 protein folding; IMP:UniProtKB. # GO_process GO:0006461 protein complex assembly; IMP:UniProtKB. # GO_process GO:0051205 protein insertion into membrane; IDA:EcoliWiki. # GO_process GO:0051260 protein homooligomerization; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0008565 protein transporter activity # GOslim_process GO:0006457 protein folding # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0008150 biological_process # HAMAP MF_01810 YidC_type1 # INDUCTION YIDC_ECOLI At mid-exponential phase in strain MC4100 there are about 2500 copies per cell (at protein level). # INTERACTION YIDC_ECOLI P03623 VIII (xeno); NbExp=5; IntAct=EBI-6400779, EBI-8482910; # IntAct P25714 31 # InterPro IPR001708 Membrane_insert_OXA1/ALB3/YidC # InterPro IPR019998 Membr_insert_YidC # InterPro IPR028053 Membr_insert_YidC_N # InterPro IPR028055 Membr_insert_YidC/Oxa1_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02044 M00335 Sec (secretion) system # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko03060 Protein export # KEGG_Pathway ko03070 Bacterial secretion system # Organism YIDC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR12428 PTHR12428 # PATRIC 32122907 VBIEscCol129921_3829 # PDB 3BLC X-ray; 2.50 A; A/B=26-340 # PDB 3BS6 X-ray; 1.80 A; A/B=56-329 # PDB 4UTQ EM; 8.00 A; A=1-548 # PIR B65173 B65173 # PRINTS PR00701 60KDINNERMP # PRINTS PR01900 YIDCPROTEIN # Pfam PF02096 60KD_IMP # Pfam PF14849 YidC_periplas # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIDC_ECOLI Membrane protein insertase YidC # RefSeq NP_418161 NC_000913.3 # RefSeq WP_000378250 NZ_LN832404.1 # SIMILARITY Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION YIDC_ECOLI Cell inner membrane {ECO 0000269|PubMed 11821429, ECO 0000269|PubMed 16079137}; Multi- pass membrane protein {ECO 0000269|PubMed 11821429, ECO 0000269|PubMed 16079137}. Note=Predominantly localized at cell poles at all stages of cell growth. # SUBUNIT YIDC_ECOLI Interacts with SecD and SecF. Component of the SecDFyajC complex, a heterotetrameric translocase complex. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration. Found in 3 different complexes in inner membrane preparations (PubMed 16079137). Can be cross-linked to FtsH, in the larger FtsH/HflKC complex. {ECO 0000269|PubMed 10675323, ECO 0000269|PubMed 11415986, ECO 0000269|PubMed 12068816, ECO 0000269|PubMed 16079137, ECO 0000269|PubMed 18387365}. # TCDB 2.A.9.3 the membrane protein insertase (yidc/alb3/oxa1) family # TIGRFAMs TIGR03592 yidC_oxa1_cterm # TIGRFAMs TIGR03593 yidC_nterm # eggNOG COG0706 LUCA # eggNOG ENOG4105DHW Bacteria BLAST swissprot:YIDC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIDC_ECOLI BioCyc ECOL316407:JW3683-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3683-MONOMER BioCyc EcoCyc:YIDC http://biocyc.org/getid?id=EcoCyc:YIDC COG COG0706 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0706 DIP DIP-12442N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12442N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1016/0378-1119(85)90206-9 http://dx.doi.org/10.1016/0378-1119(85)90206-9 DOI 10.1016/j.febslet.2008.02.082 http://dx.doi.org/10.1016/j.febslet.2008.02.082 DOI 10.1021/bi034309h http://dx.doi.org/10.1021/bi034309h DOI 10.1021/bi060826z http://dx.doi.org/10.1021/bi060826z DOI 10.1038/35020586 http://dx.doi.org/10.1038/35020586 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2002.02972.x http://dx.doi.org/10.1046/j.1365-2958.2002.02972.x DOI 10.1073/pnas.0636761100 http://dx.doi.org/10.1073/pnas.0636761100 DOI 10.1074/jbc.273.46.30415 http://dx.doi.org/10.1074/jbc.273.46.30415 DOI 10.1074/jbc.M111.245696 http://dx.doi.org/10.1074/jbc.M111.245696 DOI 10.1074/jbc.M200311200 http://dx.doi.org/10.1074/jbc.M200311200 DOI 10.1074/jbc.M301008200 http://dx.doi.org/10.1074/jbc.M301008200 DOI 10.1074/jbc.M307362200 http://dx.doi.org/10.1074/jbc.M307362200 DOI 10.1074/jbc.M403229200 http://dx.doi.org/10.1074/jbc.M403229200 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1074/jbc.M708936200 http://dx.doi.org/10.1074/jbc.M708936200 DOI 10.1074/jbc.M710493200 http://dx.doi.org/10.1074/jbc.M710493200 DOI 10.1074/jbc.M801481200 http://dx.doi.org/10.1074/jbc.M801481200 DOI 10.1083/jcb.200402067 http://dx.doi.org/10.1083/jcb.200402067 DOI 10.1093/embo-reports/kve108 http://dx.doi.org/10.1093/embo-reports/kve108 DOI 10.1093/emboj/19.4.542 http://dx.doi.org/10.1093/emboj/19.4.542 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00853-09 http://dx.doi.org/10.1128/JB.00853-09 DOI 10.1128/JB.01366-07 http://dx.doi.org/10.1128/JB.01366-07 DOI 10.1146/annurev-biochem-060409-092524 http://dx.doi.org/10.1146/annurev-biochem-060409-092524 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M11056 http://www.ebi.ac.uk/ena/data/view/M11056 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1183 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1183 EcoGene EG11197 http://www.ecogene.org/geneInfo.php?eg_id=EG11197 EnsemblBacteria AAC76728 http://www.ensemblgenomes.org/id/AAC76728 EnsemblBacteria AAC76728 http://www.ensemblgenomes.org/id/AAC76728 EnsemblBacteria BAE77588 http://www.ensemblgenomes.org/id/BAE77588 EnsemblBacteria BAE77588 http://www.ensemblgenomes.org/id/BAE77588 EnsemblBacteria BAE77588 http://www.ensemblgenomes.org/id/BAE77588 EnsemblBacteria b3705 http://www.ensemblgenomes.org/id/b3705 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0032977 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032977 GO_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GO_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GO_process GO:0051205 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051205 GO_process GO:0051260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 948214 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948214 HAMAP MF_01810 http://hamap.expasy.org/unirule/MF_01810 HOGENOM HOG000101822 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000101822&db=HOGENOM6 InParanoid P25714 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P25714 IntAct P25714 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P25714* InterPro IPR001708 http://www.ebi.ac.uk/interpro/entry/IPR001708 InterPro IPR019998 http://www.ebi.ac.uk/interpro/entry/IPR019998 InterPro IPR028053 http://www.ebi.ac.uk/interpro/entry/IPR028053 InterPro IPR028055 http://www.ebi.ac.uk/interpro/entry/IPR028055 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW3683 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3683 KEGG_Gene eco:b3705 http://www.genome.jp/dbget-bin/www_bget?eco:b3705 KEGG_Orthology KO:K03217 http://www.genome.jp/dbget-bin/www_bget?KO:K03217 KEGG_Pathway ko03060 http://www.genome.jp/kegg-bin/show_pathway?ko03060 KEGG_Pathway ko03070 http://www.genome.jp/kegg-bin/show_pathway?ko03070 MINT MINT-6477960 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-6477960 OMA KNDATHS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KNDATHS PANTHER PTHR12428 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12428 PDB 3BLC http://www.ebi.ac.uk/pdbe-srv/view/entry/3BLC PDB 3BS6 http://www.ebi.ac.uk/pdbe-srv/view/entry/3BS6 PDB 4UTQ http://www.ebi.ac.uk/pdbe-srv/view/entry/4UTQ PDBsum 3BLC http://www.ebi.ac.uk/pdbsum/3BLC PDBsum 3BS6 http://www.ebi.ac.uk/pdbsum/3BS6 PDBsum 4UTQ http://www.ebi.ac.uk/pdbsum/4UTQ PRINTS PR00701 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00701 PRINTS PR01900 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01900 PSORT swissprot:YIDC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIDC_ECOLI PSORT-B swissprot:YIDC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIDC_ECOLI PSORT2 swissprot:YIDC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIDC_ECOLI Pfam PF02096 http://pfam.xfam.org/family/PF02096 Pfam PF14849 http://pfam.xfam.org/family/PF14849 Phobius swissprot:YIDC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIDC_ECOLI PhylomeDB P25714 http://phylomedb.org/?seqid=P25714 ProteinModelPortal P25714 http://www.proteinmodelportal.org/query/uniprot/P25714 PubMed 10675323 http://www.ncbi.nlm.nih.gov/pubmed/10675323 PubMed 10949305 http://www.ncbi.nlm.nih.gov/pubmed/10949305 PubMed 11415986 http://www.ncbi.nlm.nih.gov/pubmed/11415986 PubMed 11821429 http://www.ncbi.nlm.nih.gov/pubmed/11821429 PubMed 12068816 http://www.ncbi.nlm.nih.gov/pubmed/12068816 PubMed 12707259 http://www.ncbi.nlm.nih.gov/pubmed/12707259 PubMed 12724529 http://www.ncbi.nlm.nih.gov/pubmed/12724529 PubMed 12950181 http://www.ncbi.nlm.nih.gov/pubmed/12950181 PubMed 14506280 http://www.ncbi.nlm.nih.gov/pubmed/14506280 PubMed 15067017 http://www.ncbi.nlm.nih.gov/pubmed/15067017 PubMed 15140892 http://www.ncbi.nlm.nih.gov/pubmed/15140892 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17073462 http://www.ncbi.nlm.nih.gov/pubmed/17073462 PubMed 18093969 http://www.ncbi.nlm.nih.gov/pubmed/18093969 PubMed 18178746 http://www.ncbi.nlm.nih.gov/pubmed/18178746 PubMed 18234665 http://www.ncbi.nlm.nih.gov/pubmed/18234665 PubMed 18387365 http://www.ncbi.nlm.nih.gov/pubmed/18387365 PubMed 18456666 http://www.ncbi.nlm.nih.gov/pubmed/18456666 PubMed 19717609 http://www.ncbi.nlm.nih.gov/pubmed/19717609 PubMed 21275640 http://www.ncbi.nlm.nih.gov/pubmed/21275640 PubMed 21778229 http://www.ncbi.nlm.nih.gov/pubmed/21778229 PubMed 2415431 http://www.ncbi.nlm.nih.gov/pubmed/2415431 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9804807 http://www.ncbi.nlm.nih.gov/pubmed/9804807 RefSeq NP_418161 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418161 RefSeq WP_000378250 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000378250 SMR P25714 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P25714 STRING 511145.b3705 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3705&targetmode=cogs STRING COG0706 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0706&targetmode=cogs TCDB 2.A.9.3 http://www.tcdb.org/search/result.php?tc=2.A.9.3 TIGRFAMs TIGR03592 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03592 TIGRFAMs TIGR03593 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03593 UniProtKB YIDC_ECOLI http://www.uniprot.org/uniprot/YIDC_ECOLI UniProtKB-AC P25714 http://www.uniprot.org/uniprot/P25714 charge swissprot:YIDC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIDC_ECOLI eggNOG COG0706 http://eggnogapi.embl.de/nog_data/html/tree/COG0706 eggNOG ENOG4105DHW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DHW epestfind swissprot:YIDC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIDC_ECOLI garnier swissprot:YIDC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIDC_ECOLI helixturnhelix swissprot:YIDC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIDC_ECOLI hmoment swissprot:YIDC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIDC_ECOLI iep swissprot:YIDC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIDC_ECOLI inforesidue swissprot:YIDC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIDC_ECOLI octanol swissprot:YIDC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIDC_ECOLI pepcoil swissprot:YIDC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIDC_ECOLI pepdigest swissprot:YIDC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIDC_ECOLI pepinfo swissprot:YIDC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIDC_ECOLI pepnet swissprot:YIDC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIDC_ECOLI pepstats swissprot:YIDC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIDC_ECOLI pepwheel swissprot:YIDC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIDC_ECOLI pepwindow swissprot:YIDC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIDC_ECOLI sigcleave swissprot:YIDC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIDC_ECOLI ## Database ID URL or Descriptions # EcoGene EG40004 insD3 # FUNCTION INSD3_ECOLI Involved in the transposition of the insertion sequence IS2. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006310 DNA recombination; IEA:UniProtKB-KW. # GO_process GO:0015074 DNA integration; IEA:InterPro. # GO_process GO:0032196 transposition; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 3.30.420.10 -; 1. # InterPro IPR001584 Integrase_cat-core # InterPro IPR012337 RNaseH-like_dom # InterPro IPR025948 HTH-like_dom # Organism INSD3_ECOLI Escherichia coli (strain K12) # PIR A64764 C65092 # PROSITE PS50994 INTEGRASE # Pfam PF00665 rve # Pfam PF13276 HTH_21 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSD3_ECOLI Transposase InsD for insertion element IS2F # RefSeq NP_061399 NC_002483.1 # RefSeq NP_414895 NC_000913.3 # RefSeq NP_415920 NC_000913.3 # RefSeq NP_416500 NC_000913.3 # RefSeq NP_417337 NC_000913.3 # RefSeq NP_417517 NC_000913.3 # RefSeq NP_418693 NC_000913.3 # RefSeq WP_000376502 NZ_LN832404.1 # SIMILARITY Contains 1 integrase catalytic domain. {ECO:0000255|PROSITE-ProRule PRU00457}. # SUPFAM SSF53098 SSF53098 # eggNOG ENOG4108MVM Bacteria # eggNOG ENOG410Z4Y8 LUCA BLAST swissprot:INSD3_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSD3_ECOLI DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4731 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4731 EcoGene EG40004 http://www.ecogene.org/geneInfo.php?eg_id=EG40004 EnsemblBacteria AAC75057 http://www.ensemblgenomes.org/id/AAC75057 EnsemblBacteria AAC75057 http://www.ensemblgenomes.org/id/AAC75057 EnsemblBacteria BAA15819 http://www.ensemblgenomes.org/id/BAA15819 EnsemblBacteria BAA15819 http://www.ensemblgenomes.org/id/BAA15819 EnsemblBacteria BAA15819 http://www.ensemblgenomes.org/id/BAA15819 EnsemblBacteria b1996 http://www.ensemblgenomes.org/id/b1996 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0015074 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015074 GO_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 3.30.420.10 http://www.cathdb.info/version/latest/superfamily/3.30.420.10 GeneID 1263540 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263540 GeneID 945203 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945203 GeneID 945952 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945952 GeneID 946403 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946403 GeneID 947346 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947346 GeneID 947517 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947517 GeneID 948779 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948779 InParanoid P0CF55 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CF55 InterPro IPR001584 http://www.ebi.ac.uk/interpro/entry/IPR001584 InterPro IPR012337 http://www.ebi.ac.uk/interpro/entry/IPR012337 InterPro IPR025948 http://www.ebi.ac.uk/interpro/entry/IPR025948 KEGG_Gene ecj:JW1975 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1975 KEGG_Gene eco:b0361 http://www.genome.jp/dbget-bin/www_bget?eco:b0361 KEGG_Gene eco:b1402 http://www.genome.jp/dbget-bin/www_bget?eco:b1402 KEGG_Gene eco:b1996 http://www.genome.jp/dbget-bin/www_bget?eco:b1996 KEGG_Gene eco:b2860 http://www.genome.jp/dbget-bin/www_bget?eco:b2860 KEGG_Gene eco:b3045 http://www.genome.jp/dbget-bin/www_bget?eco:b3045 KEGG_Gene eco:b4273 http://www.genome.jp/dbget-bin/www_bget?eco:b4273 PROSITE PS50994 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50994 PSORT swissprot:INSD3_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSD3_ECOLI PSORT-B swissprot:INSD3_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSD3_ECOLI PSORT2 swissprot:INSD3_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSD3_ECOLI Pfam PF00665 http://pfam.xfam.org/family/PF00665 Pfam PF13276 http://pfam.xfam.org/family/PF13276 Phobius swissprot:INSD3_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSD3_ECOLI PhylomeDB P0CF55 http://phylomedb.org/?seqid=P0CF55 ProteinModelPortal P0CF55 http://www.proteinmodelportal.org/query/uniprot/P0CF55 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_061399 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061399 RefSeq NP_414895 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414895 RefSeq NP_415920 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415920 RefSeq NP_416500 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416500 RefSeq NP_417337 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417337 RefSeq NP_417517 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417517 RefSeq NP_418693 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418693 RefSeq WP_000376502 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000376502 SMR P0CF55 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0CF55 STRING 511145.b4273 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4273&targetmode=cogs SUPFAM SSF53098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098 UniProtKB INSD3_ECOLI http://www.uniprot.org/uniprot/INSD3_ECOLI UniProtKB-AC P0CF55 http://www.uniprot.org/uniprot/P0CF55 charge swissprot:INSD3_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSD3_ECOLI eggNOG ENOG4108MVM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MVM eggNOG ENOG410Z4Y8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Z4Y8 epestfind swissprot:INSD3_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSD3_ECOLI garnier swissprot:INSD3_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSD3_ECOLI helixturnhelix swissprot:INSD3_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSD3_ECOLI hmoment swissprot:INSD3_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSD3_ECOLI iep swissprot:INSD3_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSD3_ECOLI inforesidue swissprot:INSD3_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSD3_ECOLI octanol swissprot:INSD3_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSD3_ECOLI pepcoil swissprot:INSD3_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSD3_ECOLI pepdigest swissprot:INSD3_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSD3_ECOLI pepinfo swissprot:INSD3_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSD3_ECOLI pepnet swissprot:INSD3_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSD3_ECOLI pepstats swissprot:INSD3_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSD3_ECOLI pepwheel swissprot:INSD3_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSD3_ECOLI pepwindow swissprot:INSD3_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSD3_ECOLI sigcleave swissprot:INSD3_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSD3_ECOLI ## Database ID URL or Descriptions # AltName PRLF_ECOLI HtrA suppressor protein SohA # BioGrid 4259492 399 # DISRUPTION PHENOTYPE Not essential. {ECO:0000269|PubMed 2152898}. # EcoGene EG10955 prlF # FUNCTION PRLF_ECOLI Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that binds to the YhaV toxin and neutralizes its ribonuclease activity. Also acts as a transcription factor. The YhaV/PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression. {ECO 0000269|PubMed 17706670}. # FUNCTION PRLF_ECOLI Negatively regulates its own expression as well as relieving the export block imposed by high-level synthesis of the LamB-LacZ hybrid protein. Overexpression leads to increased doubling time and also suppresses a htrA (degP) null phenotype. {ECO 0000269|PubMed 17706670}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IDA:EcoCyc. # GO_function GO:0019899 enzyme binding; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0097351 toxin-antitoxin pair type II binding; IPI:EcoCyc. # GO_process GO:0001558 regulation of cell growth; IMP:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0019899 enzyme binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # IntAct P15373 6 # InterPro IPR007159 SpoVT-AbrB_dom # InterPro IPR031848 PrlF_antitoxin # Organism PRLF_ECOLI Escherichia coli (strain K12) # PATRIC 32121674 VBIEscCol129921_3223 # PIR A35137 A35137 # PROSITE PS51740 SPOVT_ABRB # Pfam PF15937 PrlF_antitoxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PRLF_ECOLI Antitoxin PrlF # RefSeq NP_417598 NC_000913.3 # RefSeq WP_001307405 NZ_LN832404.1 # SIMILARITY Contains 1 SpoVT-AbrB domain. {ECO:0000255|PROSITE- ProRule PRU01076}. # SUBCELLULAR LOCATION PRLF_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Homodimer; forms a complex with YhaV with stoichiometry PrlF(2)-YhaV(4), possibly as a YhaV(2)-PrlF(2)-YhaV(2) complex like the MazFE complex. This complex is seen to dimerize in solution. {ECO:0000269|PubMed 17706670}. # eggNOG COG2002 LUCA # eggNOG ENOG4105ZEG Bacteria BLAST swissprot:PRLF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PRLF_ECOLI BioCyc ECOL316407:JW3098-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3098-MONOMER BioCyc EcoCyc:EG10955-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10955-MONOMER BioCyc MetaCyc:EG10955-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10955-MONOMER DOI 10.1016/S0079-6603(08)00812-X http://dx.doi.org/10.1016/S0079-6603(08)00812-X DOI 10.1016/j.jmb.2007.07.016 http://dx.doi.org/10.1016/j.jmb.2007.07.016 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M30178 http://www.ebi.ac.uk/ena/data/view/M30178 EMBL M32358 http://www.ebi.ac.uk/ena/data/view/M32358 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB0948 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0948 EcoGene EG10955 http://www.ecogene.org/geneInfo.php?eg_id=EG10955 EnsemblBacteria AAC76163 http://www.ensemblgenomes.org/id/AAC76163 EnsemblBacteria AAC76163 http://www.ensemblgenomes.org/id/AAC76163 EnsemblBacteria BAE77176 http://www.ensemblgenomes.org/id/BAE77176 EnsemblBacteria BAE77176 http://www.ensemblgenomes.org/id/BAE77176 EnsemblBacteria BAE77176 http://www.ensemblgenomes.org/id/BAE77176 EnsemblBacteria b3129 http://www.ensemblgenomes.org/id/b3129 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0019899 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0097351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097351 GO_process GO:0001558 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001558 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0019899 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 947639 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947639 HOGENOM HOG000229555 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000229555&db=HOGENOM6 InParanoid P15373 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P15373 IntAct P15373 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P15373* InterPro IPR007159 http://www.ebi.ac.uk/interpro/entry/IPR007159 InterPro IPR031848 http://www.ebi.ac.uk/interpro/entry/IPR031848 KEGG_Gene ecj:JW3098 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3098 KEGG_Gene eco:b3129 http://www.genome.jp/dbget-bin/www_bget?eco:b3129 OMA DKICYTI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DKICYTI PROSITE PS51740 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51740 PSORT swissprot:PRLF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PRLF_ECOLI PSORT-B swissprot:PRLF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PRLF_ECOLI PSORT2 swissprot:PRLF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PRLF_ECOLI Pfam PF15937 http://pfam.xfam.org/family/PF15937 Phobius swissprot:PRLF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PRLF_ECOLI PhylomeDB P15373 http://phylomedb.org/?seqid=P15373 ProteinModelPortal P15373 http://www.proteinmodelportal.org/query/uniprot/P15373 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17706670 http://www.ncbi.nlm.nih.gov/pubmed/17706670 PubMed 19215780 http://www.ncbi.nlm.nih.gov/pubmed/19215780 PubMed 2152898 http://www.ncbi.nlm.nih.gov/pubmed/2152898 PubMed 2407727 http://www.ncbi.nlm.nih.gov/pubmed/2407727 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417598 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417598 RefSeq WP_001307405 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001307405 SMR P15373 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P15373 STRING 511145.b3129 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3129&targetmode=cogs UniProtKB PRLF_ECOLI http://www.uniprot.org/uniprot/PRLF_ECOLI UniProtKB-AC P15373 http://www.uniprot.org/uniprot/P15373 charge swissprot:PRLF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PRLF_ECOLI eggNOG COG2002 http://eggnogapi.embl.de/nog_data/html/tree/COG2002 eggNOG ENOG4105ZEG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ZEG epestfind swissprot:PRLF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PRLF_ECOLI garnier swissprot:PRLF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PRLF_ECOLI helixturnhelix swissprot:PRLF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PRLF_ECOLI hmoment swissprot:PRLF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PRLF_ECOLI iep swissprot:PRLF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PRLF_ECOLI inforesidue swissprot:PRLF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PRLF_ECOLI octanol swissprot:PRLF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PRLF_ECOLI pepcoil swissprot:PRLF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PRLF_ECOLI pepdigest swissprot:PRLF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PRLF_ECOLI pepinfo swissprot:PRLF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PRLF_ECOLI pepnet swissprot:PRLF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PRLF_ECOLI pepstats swissprot:PRLF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PRLF_ECOLI pepwheel swissprot:PRLF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PRLF_ECOLI pepwindow swissprot:PRLF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PRLF_ECOLI sigcleave swissprot:PRLF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PRLF_ECOLI ## Database ID URL or Descriptions # BioGrid 4261894 266 # CDD cd00118 LysM # DISRUPTION PHENOTYPE Cells are shorter in a single mutant, double envC-nlpD disruptions have defects in septation and cell separation and form long filaments (8-fold longer). Cell length increase is more exacerbated with a triple mepM (yebA) or ygeR disruption (15-fold longer) and further yet by the quadruple disruption mutant (envC-nlpD-mepM(yebA)-ygeR, over 21-fold longer). Quadruple mutants are less sensitive to ampicillin lysis. {ECO:0000269|PubMed 19525345}. # EcoGene EG12111 nlpD # FUNCTION NLPD_ECOLI Activator of the cell wall hydrolase AmiC. Required for septal murein cleavage and daughter cell separation during cell division. {ECO 0000269|PubMed 19525345, ECO 0000269|PubMed 20300061}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_component GO:0032153 cell division site; IDA:EcoliWiki. # GO_process GO:0000917 barrier septum assembly; IMP:EcoCyc. # GO_process GO:0000920 cell separation after cytokinesis; IGI:EcoliWiki. # GO_process GO:0001896 autolysis; IGI:EcoliWiki. # GO_process GO:0042493 response to drug; IMP:EcoCyc. # GO_process GO:0051345 positive regulation of hydrolase activity; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0008150 biological_process # GOslim_process GO:0008219 cell death # GOslim_process GO:0022607 cellular component assembly # Gene3D 3.10.350.10 -; 1. # InterPro IPR011055 Dup_hybrid_motif # InterPro IPR016047 Peptidase_M23 # InterPro IPR018392 LysM_dom # Organism NLPD_ECOLI Escherichia coli (strain K12) # PATRIC 32120888 VBIEscCol129921_2836 # PIR B55522 B55522 # PROSITE PS51257 PROKAR_LIPOPROTEIN # PROSITE PS51782 LYSM # Pfam PF01476 LysM # Pfam PF01551 Peptidase_M23 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NLPD_ECOLI Murein hydrolase activator NlpD # RefSeq NP_417222 NC_000913.3 # RefSeq WP_001272592 NZ_LN832404.1 # SIMILARITY Belongs to the E.coli NlpD/Haemophilus LppB family. {ECO 0000305}. # SIMILARITY Contains 1 LysM domain. {ECO:0000255|PROSITE- ProRule PRU01118}. # SMART SM00257 LysM # SUBCELLULAR LOCATION NLPD_ECOLI Cell inner membrane {ECO 0000305}; Lipid- anchor {ECO 0000255|PROSITE-ProRule PRU00303}. Note=Localizes at the septal ring. {ECO 0000269|PubMed 19525345}. # SUPFAM SSF51261 SSF51261 # eggNOG COG0739 LUCA # eggNOG ENOG4108K5P Bacteria BLAST swissprot:NLPD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NLPD_ECOLI BioCyc ECOL316407:JW2712-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2712-MONOMER BioCyc EcoCyc:EG12111-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12111-MONOMER BioCyc MetaCyc:EG12111-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12111-MONOMER COG COG0739 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0739 DIP DIP-48067N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48067N DOI 10.1007/BF00284200 http://dx.doi.org/10.1007/BF00284200 DOI 10.1038/emboj.2010.36 http://dx.doi.org/10.1038/emboj.2010.36 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00505-09 http://dx.doi.org/10.1128/JB.00505-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D17549 http://www.ebi.ac.uk/ena/data/view/D17549 EMBL L07869 http://www.ebi.ac.uk/ena/data/view/L07869 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EchoBASE EB2034 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2034 EcoGene EG12111 http://www.ecogene.org/geneInfo.php?eg_id=EG12111 EnsemblBacteria AAC75784 http://www.ensemblgenomes.org/id/AAC75784 EnsemblBacteria AAC75784 http://www.ensemblgenomes.org/id/AAC75784 EnsemblBacteria BAE76819 http://www.ensemblgenomes.org/id/BAE76819 EnsemblBacteria BAE76819 http://www.ensemblgenomes.org/id/BAE76819 EnsemblBacteria BAE76819 http://www.ensemblgenomes.org/id/BAE76819 EnsemblBacteria b2742 http://www.ensemblgenomes.org/id/b2742 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0032153 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032153 GO_process GO:0000917 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000917 GO_process GO:0000920 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000920 GO_process GO:0001896 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001896 GO_process GO:0042493 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493 GO_process GO:0051345 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051345 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0008219 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008219 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 Gene3D 3.10.350.10 http://www.cathdb.info/version/latest/superfamily/3.10.350.10 GeneID 947011 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947011 HOGENOM HOG000159026 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000159026&db=HOGENOM6 InParanoid P0ADA3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADA3 InterPro IPR011055 http://www.ebi.ac.uk/interpro/entry/IPR011055 InterPro IPR016047 http://www.ebi.ac.uk/interpro/entry/IPR016047 InterPro IPR018392 http://www.ebi.ac.uk/interpro/entry/IPR018392 KEGG_Gene ecj:JW2712 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2712 KEGG_Gene eco:b2742 http://www.genome.jp/dbget-bin/www_bget?eco:b2742 KEGG_Orthology KO:K06194 http://www.genome.jp/dbget-bin/www_bget?KO:K06194 OMA PTYASAN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PTYASAN PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PROSITE PS51782 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51782 PSORT swissprot:NLPD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NLPD_ECOLI PSORT-B swissprot:NLPD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NLPD_ECOLI PSORT2 swissprot:NLPD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NLPD_ECOLI Pfam PF01476 http://pfam.xfam.org/family/PF01476 Pfam PF01551 http://pfam.xfam.org/family/PF01551 Phobius swissprot:NLPD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NLPD_ECOLI PhylomeDB P0ADA3 http://phylomedb.org/?seqid=P0ADA3 ProteinModelPortal P0ADA3 http://www.proteinmodelportal.org/query/uniprot/P0ADA3 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19525345 http://www.ncbi.nlm.nih.gov/pubmed/19525345 PubMed 20300061 http://www.ncbi.nlm.nih.gov/pubmed/20300061 PubMed 8132457 http://www.ncbi.nlm.nih.gov/pubmed/8132457 PubMed 8208244 http://www.ncbi.nlm.nih.gov/pubmed/8208244 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417222 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417222 RefSeq WP_001272592 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001272592 SMART SM00257 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00257 SMR P0ADA3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADA3 STRING 511145.b2742 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2742&targetmode=cogs STRING COG0739 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0739&targetmode=cogs SUPFAM SSF51261 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51261 SWISS-2DPAGE P0ADA3 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0ADA3 UniProtKB NLPD_ECOLI http://www.uniprot.org/uniprot/NLPD_ECOLI UniProtKB-AC P0ADA3 http://www.uniprot.org/uniprot/P0ADA3 charge swissprot:NLPD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NLPD_ECOLI eggNOG COG0739 http://eggnogapi.embl.de/nog_data/html/tree/COG0739 eggNOG ENOG4108K5P http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108K5P epestfind swissprot:NLPD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NLPD_ECOLI garnier swissprot:NLPD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NLPD_ECOLI helixturnhelix swissprot:NLPD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NLPD_ECOLI hmoment swissprot:NLPD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NLPD_ECOLI iep swissprot:NLPD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NLPD_ECOLI inforesidue swissprot:NLPD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NLPD_ECOLI octanol swissprot:NLPD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NLPD_ECOLI pepcoil swissprot:NLPD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NLPD_ECOLI pepdigest swissprot:NLPD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NLPD_ECOLI pepinfo swissprot:NLPD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NLPD_ECOLI pepnet swissprot:NLPD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NLPD_ECOLI pepstats swissprot:NLPD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NLPD_ECOLI pepwheel swissprot:NLPD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NLPD_ECOLI pepwindow swissprot:NLPD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NLPD_ECOLI sigcleave swissprot:NLPD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NLPD_ECOLI ## Database ID URL or Descriptions # AltName PPA_ECOLI pH 2.5 acid phosphatase # BRENDA 3.1.3.26 2026 # BioGrid 4259354 14 # CATALYTIC ACTIVITY PPA_ECOLI A phosphate monoester + H(2)O = an alcohol + phosphate. # CATALYTIC ACTIVITY PPA_ECOLI Myo-inositol hexakisphosphate + H(2)O = 1D- myo-inositol 1,2,3,5,6-pentakisphosphate + phosphate. # CDD cd07061 HP_HAP_like # EcoGene EG10049 appA # GO_component GO:0042597 periplasmic space; IDA:EcoCyc. # GO_function GO:0003993 acid phosphatase activity; IDA:EcoCyc. # GO_function GO:0008707 4-phytase activity; IDA:EcoCyc. # GO_process GO:0016036 cellular response to phosphate starvation; IDA:EcoCyc. # GO_process GO:0071454 cellular response to anoxia; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016791 phosphatase activity # GOslim_process GO:0006950 response to stress # Gene3D 3.40.50.1240 -; 3. # INDUCTION PPA_ECOLI In addition to cAMP-mediated control, this enzyme is induced when bacterial cultures reach stationary phase; its synthesis is triggered by phosphate starvation or a shift from aerobic to anaerobic conditions. # IntAct P07102 3 # InterPro IPR000560 His_Pase_clade-2 # InterPro IPR029033 His_PPase_superfam # InterPro IPR033379 Acid_Pase_AS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00562 Inositol phosphate metabolism # KEGG_Pathway ko00627 Aminobenzoate degradation # KEGG_Pathway ko00740 Riboflavin metabolism # Organism PPA_ECOLI Escherichia coli (strain K12) # PATRIC 32117183 VBIEscCol129921_1015 # PDB 1DKL X-ray; 2.30 A; A/B=23-432 # PDB 1DKM X-ray; 2.25 A; A=23-432 # PDB 1DKN X-ray; 2.40 A; A=23-432 # PDB 1DKO X-ray; 2.38 A; A=23-432 # PDB 1DKP X-ray; 2.28 A; A=23-432 # PDB 1DKQ X-ray; 2.05 A; A=23-432 # PDB 4TSR X-ray; 2.07 A; A=23-432 # PIR B36733 B36733 # PROSITE PS00616 HIS_ACID_PHOSPHAT_1 # PROSITE PS00778 HIS_ACID_PHOSPHAT_2 # Pfam PF00328 His_Phos_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PPA_ECOLI 4-phytase # RecName PPA_ECOLI Periplasmic AppA protein # RecName PPA_ECOLI Periplasmic AppA protein # RecName PPA_ECOLI Phosphoanhydride phosphohydrolase # RefSeq NP_415500 NC_000913.3 # RefSeq WP_001300464 NZ_LN832404.1 # SIMILARITY Belongs to the histidine acid phosphatase family. {ECO 0000305}. # SUBCELLULAR LOCATION PPA_ECOLI Periplasm. # SUBUNIT Monomer. {ECO:0000269|PubMed 10655611}. # SUPFAM SSF53254 SSF53254 # eggNOG ENOG4105D6F Bacteria # eggNOG ENOG410XRK8 LUCA BLAST swissprot:PPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PPA_ECOLI BioCyc ECOL316407:JW0963-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0963-MONOMER BioCyc EcoCyc:APPA-MONOMER http://biocyc.org/getid?id=EcoCyc:APPA-MONOMER BioCyc MetaCyc:APPA-MONOMER http://biocyc.org/getid?id=MetaCyc:APPA-MONOMER DOI 10.1006/abbi.1993.1261 http://dx.doi.org/10.1006/abbi.1993.1261 DOI 10.1007/BF00267454 http://dx.doi.org/10.1007/BF00267454 DOI 10.1016/0300-9084(87)90045-9 http://dx.doi.org/10.1016/0300-9084(87)90045-9 DOI 10.1038/72371 http://dx.doi.org/10.1038/72371 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1139/cjm-46-1-59 http://dx.doi.org/10.1139/cjm-46-1-59 EC_number EC:3.1.3.2 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.2 EC_number EC:3.1.3.26 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.26 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M58708 http://www.ebi.ac.uk/ena/data/view/M58708 EMBL S63811 http://www.ebi.ac.uk/ena/data/view/S63811 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X05471 http://www.ebi.ac.uk/ena/data/view/X05471 ENZYME 3.1.3.2 http://enzyme.expasy.org/EC/3.1.3.2 ENZYME 3.1.3.26 http://enzyme.expasy.org/EC/3.1.3.26 EchoBASE EB0047 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0047 EcoGene EG10049 http://www.ecogene.org/geneInfo.php?eg_id=EG10049 EnsemblBacteria AAC74065 http://www.ensemblgenomes.org/id/AAC74065 EnsemblBacteria AAC74065 http://www.ensemblgenomes.org/id/AAC74065 EnsemblBacteria BAA35745 http://www.ensemblgenomes.org/id/BAA35745 EnsemblBacteria BAA35745 http://www.ensemblgenomes.org/id/BAA35745 EnsemblBacteria BAA35745 http://www.ensemblgenomes.org/id/BAA35745 EnsemblBacteria b0980 http://www.ensemblgenomes.org/id/b0980 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0003993 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003993 GO_function GO:0008707 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008707 GO_process GO:0016036 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016036 GO_process GO:0071454 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071454 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.40.50.1240 http://www.cathdb.info/version/latest/superfamily/3.40.50.1240 GeneID 946206 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946206 HOGENOM HOG000118851 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118851&db=HOGENOM6 InParanoid P07102 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P07102 IntAct P07102 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P07102* IntEnz 3.1.3.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.2 IntEnz 3.1.3.26 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.26 InterPro IPR000560 http://www.ebi.ac.uk/interpro/entry/IPR000560 InterPro IPR029033 http://www.ebi.ac.uk/interpro/entry/IPR029033 InterPro IPR033379 http://www.ebi.ac.uk/interpro/entry/IPR033379 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0963 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0963 KEGG_Gene eco:b0980 http://www.genome.jp/dbget-bin/www_bget?eco:b0980 KEGG_Orthology KO:K01093 http://www.genome.jp/dbget-bin/www_bget?KO:K01093 KEGG_Pathway ko00562 http://www.genome.jp/kegg-bin/show_pathway?ko00562 KEGG_Pathway ko00627 http://www.genome.jp/kegg-bin/show_pathway?ko00627 KEGG_Pathway ko00740 http://www.genome.jp/kegg-bin/show_pathway?ko00740 KEGG_Reaction rn:R00548 http://www.genome.jp/dbget-bin/www_bget?rn:R00548 KEGG_Reaction rn:R03024 http://www.genome.jp/dbget-bin/www_bget?rn:R03024 KEGG_Reaction rn:R03372 http://www.genome.jp/dbget-bin/www_bget?rn:R03372 OMA KSCSLTQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KSCSLTQ PDB 1DKL http://www.ebi.ac.uk/pdbe-srv/view/entry/1DKL PDB 1DKM http://www.ebi.ac.uk/pdbe-srv/view/entry/1DKM PDB 1DKN http://www.ebi.ac.uk/pdbe-srv/view/entry/1DKN PDB 1DKO http://www.ebi.ac.uk/pdbe-srv/view/entry/1DKO PDB 1DKP http://www.ebi.ac.uk/pdbe-srv/view/entry/1DKP PDB 1DKQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1DKQ PDB 4TSR http://www.ebi.ac.uk/pdbe-srv/view/entry/4TSR PDBsum 1DKL http://www.ebi.ac.uk/pdbsum/1DKL PDBsum 1DKM http://www.ebi.ac.uk/pdbsum/1DKM PDBsum 1DKN http://www.ebi.ac.uk/pdbsum/1DKN PDBsum 1DKO http://www.ebi.ac.uk/pdbsum/1DKO PDBsum 1DKP http://www.ebi.ac.uk/pdbsum/1DKP PDBsum 1DKQ http://www.ebi.ac.uk/pdbsum/1DKQ PDBsum 4TSR http://www.ebi.ac.uk/pdbsum/4TSR PROSITE PS00616 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00616 PROSITE PS00778 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00778 PSORT swissprot:PPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PPA_ECOLI PSORT-B swissprot:PPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PPA_ECOLI PSORT2 swissprot:PPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PPA_ECOLI Pfam PF00328 http://pfam.xfam.org/family/PF00328 Phobius swissprot:PPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PPA_ECOLI PhylomeDB P07102 http://phylomedb.org/?seqid=P07102 ProteinModelPortal P07102 http://www.proteinmodelportal.org/query/uniprot/P07102 PubMed 10655611 http://www.ncbi.nlm.nih.gov/pubmed/10655611 PubMed 10696472 http://www.ncbi.nlm.nih.gov/pubmed/10696472 PubMed 1429631 http://www.ncbi.nlm.nih.gov/pubmed/1429631 PubMed 1658595 http://www.ncbi.nlm.nih.gov/pubmed/1658595 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2168385 http://www.ncbi.nlm.nih.gov/pubmed/2168385 PubMed 3038201 http://www.ncbi.nlm.nih.gov/pubmed/3038201 PubMed 8387749 http://www.ncbi.nlm.nih.gov/pubmed/8387749 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415500 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415500 RefSeq WP_001300464 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300464 SMR P07102 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P07102 STRING 511145.b0980 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0980&targetmode=cogs SUPFAM SSF53254 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53254 SWISS-2DPAGE P07102 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P07102 UniProtKB PPA_ECOLI http://www.uniprot.org/uniprot/PPA_ECOLI UniProtKB-AC P07102 http://www.uniprot.org/uniprot/P07102 charge swissprot:PPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PPA_ECOLI eggNOG ENOG4105D6F http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D6F eggNOG ENOG410XRK8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRK8 epestfind swissprot:PPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PPA_ECOLI garnier swissprot:PPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PPA_ECOLI helixturnhelix swissprot:PPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PPA_ECOLI hmoment swissprot:PPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PPA_ECOLI iep swissprot:PPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PPA_ECOLI inforesidue swissprot:PPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PPA_ECOLI octanol swissprot:PPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PPA_ECOLI pepcoil swissprot:PPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PPA_ECOLI pepdigest swissprot:PPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PPA_ECOLI pepinfo swissprot:PPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PPA_ECOLI pepnet swissprot:PPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PPA_ECOLI pepstats swissprot:PPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PPA_ECOLI pepwheel swissprot:PPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PPA_ECOLI pepwindow swissprot:PPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PPA_ECOLI sigcleave swissprot:PPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PPA_ECOLI ## Database ID URL or Descriptions # BRENDA 2.7.13 2026 # BioGrid 4261266 12 # CATALYTIC ACTIVITY ENVZ_ECOLI ATP + protein L-histidine = ADP + protein N- phospho-L-histidine. # CDD cd06225 HAMP # DOMAIN ENVZ_ECOLI The HAMP domain by itself is intrinsically disordered. {ECO 0000269|PubMed 17635923}. # ENZYME REGULATION ENVZ_ECOLI Activity is modulated by MzrA. {ECO 0000269|PubMed 19432797, ECO 0000269|PubMed 20889743}. # EcoGene EG10269 envZ # FUNCTION ENVZ_ECOLI Member of the two-component regulatory system EnvZ/OmpR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates OmpR in response to environmental signals. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0009898 cytoplasmic side of plasma membrane; IDA:EcoCyc. # GO_function GO:0000155 phosphorelay sensor kinase activity; IMP:EcoCyc. # GO_function GO:0004721 phosphoprotein phosphatase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0000160 phosphorelay signal transduction system; IDA:EcoliWiki. # GO_process GO:0006470 protein dephosphorylation; IDA:EcoliWiki. # GO_process GO:0016310 phosphorylation; IDA:EcoliWiki. # GO_process GO:0046777 protein autophosphorylation; IMP:CACAO. # GO_process GO:0047484 regulation of response to osmotic stress; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005622 intracellular # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # Gene3D 1.10.287.130 -; 1. # Gene3D 3.30.565.10 -; 1. # INTERACTION ENVZ_ECOLI P42615 mzrA; NbExp=3; IntAct=EBI-1121750, EBI-6412632; # IntAct P0AEJ4 5 # InterPro IPR003594 HATPase_C # InterPro IPR003660 HAMP_dom # InterPro IPR003661 HisK_dim/P # InterPro IPR004358 Sig_transdc_His_kin-like_C # InterPro IPR005467 His_kinase_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01001 Protein kinases # KEGG_Brite ko02022 M00445 EnvZ-OmpR (osmotic stress response) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # Organism ENVZ_ECOLI Escherichia coli (strain K12) # PATRIC 32122244 VBIEscCol129921_3499 # PDB 1BXD NMR; -; A=290-450 # PDB 1JOY NMR; -; A/B=223-289 # PDB 1NJV Model; -; A/B=223-450 # PDB 3ZCC X-ray; 1.25 A; A/B=229-288 # PDB 3ZRV X-ray; 1.65 A; A/B=229-290 # PDB 3ZRW X-ray; 2.25 A; A/C/D=229-289, B=231-289 # PDB 3ZRX X-ray; 1.25 A; A/B=229-289 # PDB 4CTI X-ray; 2.85 A; A/B/C/D=228-450 # PDB 4KP4 X-ray; 3.00 A; A/B=223-253, A/B=266-450 # PDB 5DCJ X-ray; 1.95 A; A=36-158 # PIR B25024 MMECZB # PRINTS PR00344 BCTRLSENSOR # PROSITE PS50109 HIS_KIN # PROSITE PS50885 HAMP # PTM ENVZ_ECOLI Autophosphorylated. {ECO 0000269|PubMed 8132603}. # Pfam PF00512 HisKA # Pfam PF00672 HAMP # Pfam PF02518 HATPase_c # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ENVZ_ECOLI Osmolarity sensor protein EnvZ # RefSeq NP_417863 NC_000913.3 # RefSeq WP_001253696 NZ_LN832404.1 # SIMILARITY Contains 1 HAMP domain. {ECO:0000255|PROSITE- ProRule PRU00102}. # SIMILARITY Contains 1 histidine kinase domain. {ECO:0000255|PROSITE-ProRule PRU00107}. # SMART SM00304 HAMP # SMART SM00387 HATPase_c # SMART SM00388 HisKA # SUBCELLULAR LOCATION ENVZ_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT ENVZ_ECOLI Homodimer. Interacts with MzrA. {ECO 0000269|PubMed 10426948, ECO 0000269|PubMed 15357641, ECO 0000269|PubMed 19432797, ECO 0000269|PubMed 20889743, ECO 0000269|PubMed 9817206}. # SUPFAM SSF47384 SSF47384 # SUPFAM SSF55874 SSF55874 # eggNOG ENOG4105E0F Bacteria # eggNOG ENOG410XTWD LUCA BLAST swissprot:ENVZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ENVZ_ECOLI BioCyc ECOL316407:JW3367-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3367-MONOMER BioCyc EcoCyc:ENVZ-MONOMER http://biocyc.org/getid?id=EcoCyc:ENVZ-MONOMER COG COG0642 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0642 DIP DIP-48357N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48357N DOI 10.1016/S0022-2836(03)00275-4 http://dx.doi.org/10.1016/S0022-2836(03)00275-4 DOI 10.1038/11495 http://dx.doi.org/10.1038/11495 DOI 10.1038/23968 http://dx.doi.org/10.1038/23968 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/BJ20041125 http://dx.doi.org/10.1042/BJ20041125 DOI 10.1074/jbc.M701342200 http://dx.doi.org/10.1074/jbc.M701342200 DOI 10.1111/j.1365-2958.2009.06728.x http://dx.doi.org/10.1111/j.1365-2958.2009.06728.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00855-10 http://dx.doi.org/10.1128/JB.00855-10 EC_number EC:2.7.13.3 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.13.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01656 http://www.ebi.ac.uk/ena/data/view/J01656 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 2.7.13.3 http://enzyme.expasy.org/EC/2.7.13.3 EchoBASE EB0265 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0265 EcoGene EG10269 http://www.ecogene.org/geneInfo.php?eg_id=EG10269 EnsemblBacteria AAC76429 http://www.ensemblgenomes.org/id/AAC76429 EnsemblBacteria AAC76429 http://www.ensemblgenomes.org/id/AAC76429 EnsemblBacteria BAE77887 http://www.ensemblgenomes.org/id/BAE77887 EnsemblBacteria BAE77887 http://www.ensemblgenomes.org/id/BAE77887 EnsemblBacteria BAE77887 http://www.ensemblgenomes.org/id/BAE77887 EnsemblBacteria b3404 http://www.ensemblgenomes.org/id/b3404 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0009898 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009898 GO_function GO:0000155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000155 GO_function GO:0004721 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004721 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006470 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006470 GO_process GO:0016310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016310 GO_process GO:0046777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046777 GO_process GO:0047484 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047484 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.10.287.130 http://www.cathdb.info/version/latest/superfamily/1.10.287.130 Gene3D 3.30.565.10 http://www.cathdb.info/version/latest/superfamily/3.30.565.10 GeneID 947272 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947272 HOGENOM HOG000218774 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218774&db=HOGENOM6 InParanoid P0AEJ4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEJ4 IntAct P0AEJ4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEJ4* IntEnz 2.7.13.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.13.3 InterPro IPR003594 http://www.ebi.ac.uk/interpro/entry/IPR003594 InterPro IPR003660 http://www.ebi.ac.uk/interpro/entry/IPR003660 InterPro IPR003661 http://www.ebi.ac.uk/interpro/entry/IPR003661 InterPro IPR004358 http://www.ebi.ac.uk/interpro/entry/IPR004358 InterPro IPR005467 http://www.ebi.ac.uk/interpro/entry/IPR005467 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01001 http://www.genome.jp/dbget-bin/www_bget?ko01001 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW3367 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3367 KEGG_Gene eco:b3404 http://www.genome.jp/dbget-bin/www_bget?eco:b3404 KEGG_Orthology KO:K07638 http://www.genome.jp/dbget-bin/www_bget?KO:K07638 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 MINT MINT-8398485 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8398485 OMA WIRPPQA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WIRPPQA PDB 1BXD http://www.ebi.ac.uk/pdbe-srv/view/entry/1BXD PDB 1JOY http://www.ebi.ac.uk/pdbe-srv/view/entry/1JOY PDB 1NJV http://www.ebi.ac.uk/pdbe-srv/view/entry/1NJV PDB 3ZCC http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZCC PDB 3ZRV http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZRV PDB 3ZRW http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZRW PDB 3ZRX http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZRX PDB 4CTI http://www.ebi.ac.uk/pdbe-srv/view/entry/4CTI PDB 4KP4 http://www.ebi.ac.uk/pdbe-srv/view/entry/4KP4 PDB 5DCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/5DCJ PDBsum 1BXD http://www.ebi.ac.uk/pdbsum/1BXD PDBsum 1JOY http://www.ebi.ac.uk/pdbsum/1JOY PDBsum 1NJV http://www.ebi.ac.uk/pdbsum/1NJV PDBsum 3ZCC http://www.ebi.ac.uk/pdbsum/3ZCC PDBsum 3ZRV http://www.ebi.ac.uk/pdbsum/3ZRV PDBsum 3ZRW http://www.ebi.ac.uk/pdbsum/3ZRW PDBsum 3ZRX http://www.ebi.ac.uk/pdbsum/3ZRX PDBsum 4CTI http://www.ebi.ac.uk/pdbsum/4CTI PDBsum 4KP4 http://www.ebi.ac.uk/pdbsum/4KP4 PDBsum 5DCJ http://www.ebi.ac.uk/pdbsum/5DCJ PRINTS PR00344 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00344 PROSITE PS50109 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50109 PROSITE PS50885 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50885 PSORT swissprot:ENVZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ENVZ_ECOLI PSORT-B swissprot:ENVZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ENVZ_ECOLI PSORT2 swissprot:ENVZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ENVZ_ECOLI Pfam PF00512 http://pfam.xfam.org/family/PF00512 Pfam PF00672 http://pfam.xfam.org/family/PF00672 Pfam PF02518 http://pfam.xfam.org/family/PF02518 Phobius swissprot:ENVZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ENVZ_ECOLI PhylomeDB P0AEJ4 http://phylomedb.org/?seqid=P0AEJ4 ProteinModelPortal P0AEJ4 http://www.proteinmodelportal.org/query/uniprot/P0AEJ4 PubMed 10426948 http://www.ncbi.nlm.nih.gov/pubmed/10426948 PubMed 12691749 http://www.ncbi.nlm.nih.gov/pubmed/12691749 PubMed 1323560 http://www.ncbi.nlm.nih.gov/pubmed/1323560 PubMed 15357641 http://www.ncbi.nlm.nih.gov/pubmed/15357641 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17635923 http://www.ncbi.nlm.nih.gov/pubmed/17635923 PubMed 19432797 http://www.ncbi.nlm.nih.gov/pubmed/19432797 PubMed 20889743 http://www.ncbi.nlm.nih.gov/pubmed/20889743 PubMed 2277041 http://www.ncbi.nlm.nih.gov/pubmed/2277041 PubMed 2824492 http://www.ncbi.nlm.nih.gov/pubmed/2824492 PubMed 2997120 http://www.ncbi.nlm.nih.gov/pubmed/2997120 PubMed 6292200 http://www.ncbi.nlm.nih.gov/pubmed/6292200 PubMed 8132603 http://www.ncbi.nlm.nih.gov/pubmed/8132603 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9817206 http://www.ncbi.nlm.nih.gov/pubmed/9817206 RefSeq NP_417863 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417863 RefSeq WP_001253696 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001253696 SMART SM00304 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00304 SMART SM00387 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00387 SMART SM00388 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00388 SMR P0AEJ4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEJ4 STRING 511145.b3404 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3404&targetmode=cogs STRING COG0642 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0642&targetmode=cogs SUPFAM SSF47384 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47384 SUPFAM SSF55874 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55874 UniProtKB ENVZ_ECOLI http://www.uniprot.org/uniprot/ENVZ_ECOLI UniProtKB-AC P0AEJ4 http://www.uniprot.org/uniprot/P0AEJ4 charge swissprot:ENVZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ENVZ_ECOLI eggNOG ENOG4105E0F http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E0F eggNOG ENOG410XTWD http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XTWD epestfind swissprot:ENVZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ENVZ_ECOLI garnier swissprot:ENVZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ENVZ_ECOLI helixturnhelix swissprot:ENVZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ENVZ_ECOLI hmoment swissprot:ENVZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ENVZ_ECOLI iep swissprot:ENVZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ENVZ_ECOLI inforesidue swissprot:ENVZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ENVZ_ECOLI octanol swissprot:ENVZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ENVZ_ECOLI pepcoil swissprot:ENVZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ENVZ_ECOLI pepdigest swissprot:ENVZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ENVZ_ECOLI pepinfo swissprot:ENVZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ENVZ_ECOLI pepnet swissprot:ENVZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ENVZ_ECOLI pepstats swissprot:ENVZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ENVZ_ECOLI pepwheel swissprot:ENVZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ENVZ_ECOLI pepwindow swissprot:ENVZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ENVZ_ECOLI sigcleave swissprot:ENVZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ENVZ_ECOLI ## Database ID URL or Descriptions # FUNCTION TRBE_ECOLI Not determined yet. Not required for conjugation transfer in rich, aerobic growth media. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR020150 T4SS_TrbE # Organism TRBE_ECOLI Escherichia coli (strain K12) # PIR S23992 S23992 # Pfam PF11100 TrbE # ProDom PD028820 T4SS_TrbE # RecName TRBE_ECOLI Protein TrbE # RefSeq NP_061469 NC_002483.1 # RefSeq NP_862935 NC_004998.1 # RefSeq WP_001324101 NC_002483.1 # RefSeq YP_001816536 NC_010558.1 # RefSeq YP_001965432 NC_010862.1 # RefSeq YP_009068334 NC_025139.1 # RefSeq YP_009070599 NC_025175.1 # SUBCELLULAR LOCATION TRBE_ECOLI Cell inner membrane; Multi-pass membrane protein. BLAST swissprot:TRBE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRBE_ECOLI DOI 10.1016/0022-2836(92)90923-8 http://dx.doi.org/10.1016/0022-2836(92)90923-8 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL U01159 http://www.ebi.ac.uk/ena/data/view/U01159 EMBL X61575 http://www.ebi.ac.uk/ena/data/view/X61575 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 1263550 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263550 GeneID 1446499 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1446499 GeneID 20491464 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20491464 GeneID 20492667 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20492667 GeneID 6276066 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6276066 GeneID 6382228 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6382228 InterPro IPR020150 http://www.ebi.ac.uk/interpro/entry/IPR020150 OMA XDERNED http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=XDERNED PSORT swissprot:TRBE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRBE_ECOLI PSORT-B swissprot:TRBE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRBE_ECOLI PSORT2 swissprot:TRBE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRBE_ECOLI Pfam PF11100 http://pfam.xfam.org/family/PF11100 Phobius swissprot:TRBE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRBE_ECOLI ProteinModelPortal Q05807 http://www.proteinmodelportal.org/query/uniprot/Q05807 PubMed 1593622 http://www.ncbi.nlm.nih.gov/pubmed/1593622 PubMed 7915817 http://www.ncbi.nlm.nih.gov/pubmed/7915817 RefSeq NP_061469 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061469 RefSeq NP_862935 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_862935 RefSeq WP_001324101 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001324101 RefSeq YP_001816536 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001816536 RefSeq YP_001965432 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001965432 RefSeq YP_009068334 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009068334 RefSeq YP_009070599 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009070599 UniProtKB TRBE_ECOLI http://www.uniprot.org/uniprot/TRBE_ECOLI UniProtKB-AC Q05807 http://www.uniprot.org/uniprot/Q05807 charge swissprot:TRBE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRBE_ECOLI epestfind swissprot:TRBE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRBE_ECOLI garnier swissprot:TRBE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRBE_ECOLI helixturnhelix swissprot:TRBE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRBE_ECOLI hmoment swissprot:TRBE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRBE_ECOLI iep swissprot:TRBE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRBE_ECOLI inforesidue swissprot:TRBE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRBE_ECOLI octanol swissprot:TRBE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRBE_ECOLI pepcoil swissprot:TRBE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRBE_ECOLI pepdigest swissprot:TRBE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRBE_ECOLI pepinfo swissprot:TRBE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRBE_ECOLI pepnet swissprot:TRBE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRBE_ECOLI pepstats swissprot:TRBE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRBE_ECOLI pepwheel swissprot:TRBE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRBE_ECOLI pepwindow swissprot:TRBE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRBE_ECOLI sigcleave swissprot:TRBE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRBE_ECOLI ## Database ID URL or Descriptions # BioGrid 4259127 249 # EcoGene EG13930 ydgI # FUNCTION ARCD_ECOLI Catalyzes an electroneutral exchange between arginine and ornithine to allow high-efficiency energy conversion in the arginine deiminase pathway. {ECO 0000250}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0015179 L-amino acid transmembrane transporter activity; IBA:GO_Central. # GO_function GO:0015297 antiporter activity; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # InterPro IPR002293 AA/rel_permease1 # InterPro IPR004754 Amino_acid_antiprt # KEGG_Brite ko02000 Transporters # Organism ARCD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11785 PTHR11785 # PATRIC 32118512 VBIEscCol129921_1676 # PIR G64916 G64916 # PIRSF PIRSF006060 AA_transporter # Pfam PF13520 AA_permease_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ARCD_ECOLI Putative arginine/ornithine antiporter # RefSeq NP_416122 NC_000913.3 # RefSeq WP_000412379 NZ_LN832404.1 # SIMILARITY Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family. {ECO 0000305}. # SUBCELLULAR LOCATION ARCD_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.3.2 the amino acid-polyamine-organocation (apc) family # TIGRFAMs TIGR00905 2A0302 # eggNOG COG0531 LUCA # eggNOG ENOG4105D5Q Bacteria BLAST swissprot:ARCD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARCD_ECOLI BioCyc ECOL316407:JW1597-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1597-MONOMER BioCyc EcoCyc:ARCD-MONOMER http://biocyc.org/getid?id=EcoCyc:ARCD-MONOMER COG COG0531 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0531 DIP DIP-48049N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48049N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3689 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3689 EcoGene EG13930 http://www.ecogene.org/geneInfo.php?eg_id=EG13930 EnsemblBacteria AAC74677 http://www.ensemblgenomes.org/id/AAC74677 EnsemblBacteria AAC74677 http://www.ensemblgenomes.org/id/AAC74677 EnsemblBacteria BAA15343 http://www.ensemblgenomes.org/id/BAA15343 EnsemblBacteria BAA15343 http://www.ensemblgenomes.org/id/BAA15343 EnsemblBacteria BAA15343 http://www.ensemblgenomes.org/id/BAA15343 EnsemblBacteria b1605 http://www.ensemblgenomes.org/id/b1605 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015179 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015179 GO_function GO:0015297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015297 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GeneID 945159 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945159 HOGENOM HOG000164505 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000164505&db=HOGENOM6 InParanoid P0AAE5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAE5 IntAct P0AAE5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAE5* InterPro IPR002293 http://www.ebi.ac.uk/interpro/entry/IPR002293 InterPro IPR004754 http://www.ebi.ac.uk/interpro/entry/IPR004754 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1597 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1597 KEGG_Gene eco:b1605 http://www.genome.jp/dbget-bin/www_bget?eco:b1605 KEGG_Orthology KO:K03758 http://www.genome.jp/dbget-bin/www_bget?KO:K03758 OMA VHWLVLR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VHWLVLR PANTHER PTHR11785 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11785 PSORT swissprot:ARCD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARCD_ECOLI PSORT-B swissprot:ARCD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARCD_ECOLI PSORT2 swissprot:ARCD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARCD_ECOLI Pfam PF13520 http://pfam.xfam.org/family/PF13520 Phobius swissprot:ARCD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARCD_ECOLI PhylomeDB P0AAE5 http://phylomedb.org/?seqid=P0AAE5 ProteinModelPortal P0AAE5 http://www.proteinmodelportal.org/query/uniprot/P0AAE5 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416122 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416122 RefSeq WP_000412379 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000412379 STRING 511145.b1605 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1605&targetmode=cogs STRING COG0531 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0531&targetmode=cogs TCDB 2.A.3.2 http://www.tcdb.org/search/result.php?tc=2.A.3.2 TIGRFAMs TIGR00905 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00905 UniProtKB ARCD_ECOLI http://www.uniprot.org/uniprot/ARCD_ECOLI UniProtKB-AC P0AAE5 http://www.uniprot.org/uniprot/P0AAE5 charge swissprot:ARCD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARCD_ECOLI eggNOG COG0531 http://eggnogapi.embl.de/nog_data/html/tree/COG0531 eggNOG ENOG4105D5Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D5Q epestfind swissprot:ARCD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARCD_ECOLI garnier swissprot:ARCD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARCD_ECOLI helixturnhelix swissprot:ARCD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARCD_ECOLI hmoment swissprot:ARCD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARCD_ECOLI iep swissprot:ARCD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARCD_ECOLI inforesidue swissprot:ARCD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARCD_ECOLI octanol swissprot:ARCD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARCD_ECOLI pepcoil swissprot:ARCD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARCD_ECOLI pepdigest swissprot:ARCD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARCD_ECOLI pepinfo swissprot:ARCD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARCD_ECOLI pepnet swissprot:ARCD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARCD_ECOLI pepstats swissprot:ARCD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARCD_ECOLI pepwheel swissprot:ARCD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARCD_ECOLI pepwindow swissprot:ARCD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARCD_ECOLI sigcleave swissprot:ARCD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARCD_ECOLI ## Database ID URL or Descriptions # DISRUPTION PHENOTYPE None seen. An isbC overproducing strain cannot be made in the absence of the sibC gene. {ECO:0000269|PubMed 18710431}. # EcoGene EG14470 ibsC # FUNCTION IBSC_ECOLI May be a toxic protein; overexpression causes cessation of growth and rapid membrane depolarization. Overexpression induces stress-response, the psp phage shock and a number of membrane protein genes. {ECO 0000269|PubMed 18710431}. # GO_process GO:0012501 programmed cell death; IMP:EcoCyc. # GOslim_process GO:0008219 cell death # INDUCTION The sibC sRNA prevents the toxic effects of IbsC overproduction, either by destabilizing the transcript and/or preventing its translation. A type I toxin antitoxin (TA) system, where expression of the proteinaceous toxin is controlled by an antisense sRNA. {ECO:0000269|PubMed 18710431}. # InterPro IPR025881 Toxin_Ibs # MISCELLANEOUS IBSC_ECOLI Part of the SIBc repeat region (formerly known as QUAD1c), encoded on the opposite strand from the sibC (formerly known as rygC) RNA. # Organism IBSC_ECOLI Escherichia coli (strain K12) # Pfam PF13956 Ibs_toxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName IBSC_ECOLI Small toxic protein IbsC # RefSeq YP_002791255 NC_000913.3 # SIMILARITY Belongs to the toxic protein ibs family. {ECO 0000305}. BLAST swissprot:IBSC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:IBSC_ECOLI BioCyc EcoCyc:MONOMER0-2857 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2857 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2008.06394.x http://dx.doi.org/10.1111/j.1365-2958.2008.06394.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14470 http://www.ecogene.org/geneInfo.php?eg_id=EG14470 EnsemblBacteria ACO60007 http://www.ensemblgenomes.org/id/ACO60007 EnsemblBacteria ACO60007 http://www.ensemblgenomes.org/id/ACO60007 EnsemblBacteria b4665 http://www.ensemblgenomes.org/id/b4665 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0012501 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0012501 GOslim_process GO:0008219 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008219 GeneID 7751627 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7751627 InterPro IPR025881 http://www.ebi.ac.uk/interpro/entry/IPR025881 KEGG_Gene eco:b4665 http://www.genome.jp/dbget-bin/www_bget?eco:b4665 PSORT swissprot:IBSC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:IBSC_ECOLI PSORT-B swissprot:IBSC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:IBSC_ECOLI PSORT2 swissprot:IBSC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:IBSC_ECOLI Pfam PF13956 http://pfam.xfam.org/family/PF13956 Phobius swissprot:IBSC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:IBSC_ECOLI PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18710431 http://www.ncbi.nlm.nih.gov/pubmed/18710431 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq YP_002791255 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_002791255 UniProtKB IBSC_ECOLI http://www.uniprot.org/uniprot/IBSC_ECOLI UniProtKB-AC C1P615 http://www.uniprot.org/uniprot/C1P615 charge swissprot:IBSC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:IBSC_ECOLI epestfind swissprot:IBSC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:IBSC_ECOLI garnier swissprot:IBSC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:IBSC_ECOLI helixturnhelix swissprot:IBSC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:IBSC_ECOLI hmoment swissprot:IBSC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:IBSC_ECOLI iep swissprot:IBSC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:IBSC_ECOLI inforesidue swissprot:IBSC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:IBSC_ECOLI octanol swissprot:IBSC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:IBSC_ECOLI pepcoil swissprot:IBSC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:IBSC_ECOLI pepdigest swissprot:IBSC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:IBSC_ECOLI pepinfo swissprot:IBSC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:IBSC_ECOLI pepnet swissprot:IBSC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:IBSC_ECOLI pepstats swissprot:IBSC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:IBSC_ECOLI pepwheel swissprot:IBSC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:IBSC_ECOLI pepwindow swissprot:IBSC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:IBSC_ECOLI sigcleave swissprot:IBSC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:IBSC_ECOLI ## Database ID URL or Descriptions # AltName TYPH_ECOLI TdRPase # BRENDA 2.4.2 2026 # BioGrid 4262779 9 # CATALYTIC ACTIVITY TYPH_ECOLI Thymidine + phosphate = thymine + 2-deoxy- alpha-D-ribose 1-phosphate. # EcoGene EG10219 deoA # FUNCTION TYPH_ECOLI The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0004645 phosphorylase activity; IBA:GO_Central. # GO_function GO:0009032 thymidine phosphorylase activity; IDA:EcoCyc. # GO_function GO:0016154 pyrimidine-nucleoside phosphorylase activity; IEA:InterPro. # GO_process GO:0006206 pyrimidine nucleobase metabolic process; IEA:InterPro. # GO_process GO:0006220 pyrimidine nucleotide metabolic process; IBA:GO_Central. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0046104 thymidine metabolic process; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_process GO:0006950 response to stress # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.1030.10 -; 1. # Gene3D 3.90.1170.30 -; 1. # HAMAP MF_01628 Thymid_phosp # IntAct P07650 2 # InterPro IPR000053 Thymidine/pyrmidine_PPase # InterPro IPR000312 Glycosyl_Trfase_fam3 # InterPro IPR013102 PYNP_C # InterPro IPR013465 Thymidine_Pase # InterPro IPR017459 Glycosyl_Trfase_fam3_N_dom # InterPro IPR017872 Pyrmidine_PPase_CS # InterPro IPR018090 Pyrmidine_PPas_bac/euk # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00240 Pyrimidine metabolism # KEGG_Pathway ko00983 Drug metabolism - other enzymes # KEGG_Pathway ko05219 Bladder cancer # Organism TYPH_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10515 PTHR10515 # PATHWAY Pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine step 1/2. # PATRIC 32124380 VBIEscCol129921_4530 # PDB 1AZY X-ray; 3.00 A; A/B=2-440 # PDB 1OTP X-ray; 2.80 A; A=2-440 # PDB 1TPT X-ray; 2.80 A; A=2-440 # PDB 2TPT X-ray; 2.60 A; A=2-440 # PDB 4EAD X-ray; 1.50 A; A=2-440 # PDB 4EAF X-ray; 1.55 A; A=2-440 # PDB 4LHM X-ray; 1.52 A; A=2-440 # PIR S56606 S56606 # PIRSF PIRSF000478 TP_PyNP # PROSITE PS00647 THYMID_PHOSPHORYLASE # Pfam PF00591 Glycos_transf_3 # Pfam PF02885 Glycos_trans_3N # Pfam PF07831 PYNP_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TYPH_ECOLI Thymidine phosphorylase # RefSeq NP_418799 NC_000913.3 # RefSeq WP_000477807 NZ_LN832404.1 # SIMILARITY Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. {ECO 0000305}. # SMART SM00941 PYNP_C # SUBUNIT TYPH_ECOLI Homodimer. # SUPFAM SSF47648 SSF47648 # SUPFAM SSF52418 SSF52418 # SUPFAM SSF54680 SSF54680 # TIGRFAMs TIGR02643 T_phosphoryl # TIGRFAMs TIGR02644 Y_phosphoryl # UniPathway UPA00578 UER00638 # eggNOG COG0213 LUCA # eggNOG ENOG4105CMW Bacteria BLAST swissprot:TYPH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TYPH_ECOLI BioCyc ECOL316407:JW4345-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4345-MONOMER BioCyc EcoCyc:DEOA-MONOMER http://biocyc.org/getid?id=EcoCyc:DEOA-MONOMER BioCyc MetaCyc:DEOA-MONOMER http://biocyc.org/getid?id=MetaCyc:DEOA-MONOMER COG COG0213 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0213 DIP DIP-9426N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9426N DOI 10.1006/jmbi.1998.1941 http://dx.doi.org/10.1006/jmbi.1998.1941 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/12.13.5211 http://dx.doi.org/10.1093/nar/12.13.5211 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.4.2.4 http://www.genome.jp/dbget-bin/www_bget?EC:2.4.2.4 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X00742 http://www.ebi.ac.uk/ena/data/view/X00742 EMBL X03224 http://www.ebi.ac.uk/ena/data/view/X03224 ENZYME 2.4.2.4 http://enzyme.expasy.org/EC/2.4.2.4 EchoBASE EB0215 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0215 EcoGene EG10219 http://www.ecogene.org/geneInfo.php?eg_id=EG10219 EnsemblBacteria AAC77335 http://www.ensemblgenomes.org/id/AAC77335 EnsemblBacteria AAC77335 http://www.ensemblgenomes.org/id/AAC77335 EnsemblBacteria BAE78371 http://www.ensemblgenomes.org/id/BAE78371 EnsemblBacteria BAE78371 http://www.ensemblgenomes.org/id/BAE78371 EnsemblBacteria BAE78371 http://www.ensemblgenomes.org/id/BAE78371 EnsemblBacteria b4382 http://www.ensemblgenomes.org/id/b4382 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0004645 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004645 GO_function GO:0009032 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009032 GO_function GO:0016154 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016154 GO_process GO:0006206 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006206 GO_process GO:0006220 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006220 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0046104 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046104 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.1030.10 http://www.cathdb.info/version/latest/superfamily/3.40.1030.10 Gene3D 3.90.1170.30 http://www.cathdb.info/version/latest/superfamily/3.90.1170.30 GeneID 948901 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948901 HAMAP MF_01628 http://hamap.expasy.org/unirule/MF_01628 HOGENOM HOG000047313 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000047313&db=HOGENOM6 InParanoid P07650 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P07650 IntAct P07650 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P07650* IntEnz 2.4.2.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.2.4 InterPro IPR000053 http://www.ebi.ac.uk/interpro/entry/IPR000053 InterPro IPR000312 http://www.ebi.ac.uk/interpro/entry/IPR000312 InterPro IPR013102 http://www.ebi.ac.uk/interpro/entry/IPR013102 InterPro IPR013465 http://www.ebi.ac.uk/interpro/entry/IPR013465 InterPro IPR017459 http://www.ebi.ac.uk/interpro/entry/IPR017459 InterPro IPR017872 http://www.ebi.ac.uk/interpro/entry/IPR017872 InterPro IPR018090 http://www.ebi.ac.uk/interpro/entry/IPR018090 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4345 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4345 KEGG_Gene eco:b4382 http://www.genome.jp/dbget-bin/www_bget?eco:b4382 KEGG_Orthology KO:K00758 http://www.genome.jp/dbget-bin/www_bget?KO:K00758 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Pathway ko00983 http://www.genome.jp/kegg-bin/show_pathway?ko00983 KEGG_Pathway ko05219 http://www.genome.jp/kegg-bin/show_pathway?ko05219 KEGG_Reaction rn:R01570 http://www.genome.jp/dbget-bin/www_bget?rn:R01570 KEGG_Reaction rn:R02484 http://www.genome.jp/dbget-bin/www_bget?rn:R02484 KEGG_Reaction rn:R08222 http://www.genome.jp/dbget-bin/www_bget?rn:R08222 KEGG_Reaction rn:R08230 http://www.genome.jp/dbget-bin/www_bget?rn:R08230 OMA IGNRLEV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IGNRLEV PANTHER PTHR10515 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10515 PDB 1AZY http://www.ebi.ac.uk/pdbe-srv/view/entry/1AZY PDB 1OTP http://www.ebi.ac.uk/pdbe-srv/view/entry/1OTP PDB 1TPT http://www.ebi.ac.uk/pdbe-srv/view/entry/1TPT PDB 2TPT http://www.ebi.ac.uk/pdbe-srv/view/entry/2TPT PDB 4EAD http://www.ebi.ac.uk/pdbe-srv/view/entry/4EAD PDB 4EAF http://www.ebi.ac.uk/pdbe-srv/view/entry/4EAF PDB 4LHM http://www.ebi.ac.uk/pdbe-srv/view/entry/4LHM PDBsum 1AZY http://www.ebi.ac.uk/pdbsum/1AZY PDBsum 1OTP http://www.ebi.ac.uk/pdbsum/1OTP PDBsum 1TPT http://www.ebi.ac.uk/pdbsum/1TPT PDBsum 2TPT http://www.ebi.ac.uk/pdbsum/2TPT PDBsum 4EAD http://www.ebi.ac.uk/pdbsum/4EAD PDBsum 4EAF http://www.ebi.ac.uk/pdbsum/4EAF PDBsum 4LHM http://www.ebi.ac.uk/pdbsum/4LHM PROSITE PS00647 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00647 PSORT swissprot:TYPH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TYPH_ECOLI PSORT-B swissprot:TYPH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TYPH_ECOLI PSORT2 swissprot:TYPH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TYPH_ECOLI Pfam PF00591 http://pfam.xfam.org/family/PF00591 Pfam PF02885 http://pfam.xfam.org/family/PF02885 Pfam PF07831 http://pfam.xfam.org/family/PF07831 Phobius swissprot:TYPH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TYPH_ECOLI PhylomeDB P07650 http://phylomedb.org/?seqid=P07650 ProteinModelPortal P07650 http://www.proteinmodelportal.org/query/uniprot/P07650 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2199449 http://www.ncbi.nlm.nih.gov/pubmed/2199449 PubMed 6087276 http://www.ncbi.nlm.nih.gov/pubmed/6087276 PubMed 6323164 http://www.ncbi.nlm.nih.gov/pubmed/6323164 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9698549 http://www.ncbi.nlm.nih.gov/pubmed/9698549 RefSeq NP_418799 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418799 RefSeq WP_000477807 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000477807 SMART SM00941 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00941 SMR P07650 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P07650 STRING 511145.b4382 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4382&targetmode=cogs STRING COG0213 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0213&targetmode=cogs SUPFAM SSF47648 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47648 SUPFAM SSF52418 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52418 SUPFAM SSF54680 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54680 TIGRFAMs TIGR02643 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02643 TIGRFAMs TIGR02644 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02644 UniProtKB TYPH_ECOLI http://www.uniprot.org/uniprot/TYPH_ECOLI UniProtKB-AC P07650 http://www.uniprot.org/uniprot/P07650 charge swissprot:TYPH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TYPH_ECOLI eggNOG COG0213 http://eggnogapi.embl.de/nog_data/html/tree/COG0213 eggNOG ENOG4105CMW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CMW epestfind swissprot:TYPH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TYPH_ECOLI garnier swissprot:TYPH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TYPH_ECOLI helixturnhelix swissprot:TYPH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TYPH_ECOLI hmoment swissprot:TYPH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TYPH_ECOLI iep swissprot:TYPH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TYPH_ECOLI inforesidue swissprot:TYPH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TYPH_ECOLI octanol swissprot:TYPH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TYPH_ECOLI pepcoil swissprot:TYPH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TYPH_ECOLI pepdigest swissprot:TYPH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TYPH_ECOLI pepinfo swissprot:TYPH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TYPH_ECOLI pepnet swissprot:TYPH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TYPH_ECOLI pepstats swissprot:TYPH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TYPH_ECOLI pepwheel swissprot:TYPH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TYPH_ECOLI pepwindow swissprot:TYPH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TYPH_ECOLI sigcleave swissprot:TYPH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TYPH_ECOLI ## Database ID URL or Descriptions # AltName SYI_ECOLI Isoleucyl-tRNA synthetase # BIOPHYSICOCHEMICAL PROPERTIES SYI_ECOLI Kinetic parameters KM=5 uM for isoleucine {ECO 0000269|PubMed 3282306}; KM=0.4 mM for ATP {ECO 0000269|PubMed 3282306}; # CATALYTIC ACTIVITY SYI_ECOLI ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile). # CDD cd07960 Anticodon_Ia_Ile_BEm # COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI 29105; Note=Binds 1 zinc ion per subunit.; # DOMAIN SYI_ECOLI IleRS has two distinct active sites one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)). # EcoGene EG10492 ileS # FUNCTION SYI_ECOLI Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000049 tRNA binding; IEA:InterPro. # GO_function GO:0002161 aminoacyl-tRNA editing activity; IEA:InterPro. # GO_function GO:0004822 isoleucine-tRNA ligase activity; IDA:GO_Central. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_process GO:0006428 isoleucyl-tRNA aminoacylation; IDA:EcoCyc. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0008150 biological_process # Gene3D 1.10.730.10 -; 1. # Gene3D 3.40.50.620 -; 2. # Gene3D 3.90.740.10 -; 1. # HAMAP MF_02002 Ile_tRNA_synth_type1 # IntAct P00956 16 # InterPro IPR001412 aa-tRNA-synth_I_CS # InterPro IPR002300 aa-tRNA-synth_Ia # InterPro IPR002301 Ile-tRNA-ligase # InterPro IPR009008 Val/Leu/Ile-tRNA-synth_edit # InterPro IPR009080 tRNAsynth_Ia_anticodon-bd # InterPro IPR010663 Znf_FPG/IleRS # InterPro IPR013155 M/V/L/I-tRNA-synth_anticd-bd # InterPro IPR014729 Rossmann-like_a/b/a_fold # InterPro IPR023585 Ile-tRNA-ligase_type1 # InterPro IPR033708 Anticodon_Ile_BEm # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01007 Amino acid related enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # KEGG_Pathway ko00970 Aminoacyl-tRNA biosynthesis # MISCELLANEOUS SYI_ECOLI Strain PS102 is resistant to the antibiotic mupirocin (pseudomonic acid A), an Ile-analog that competitively inhibits activation by Ile-tRNA synthetase, thus inhibiting protein biosynthesis. # Organism SYI_ECOLI Escherichia coli (strain K12) # PATRIC 32115143 VBIEscCol129921_0023 # PIR B64723 SYECIT # PRINTS PR00984 TRNASYNTHILE # PROSITE PS00178 AA_TRNA_LIGASE_I # Pfam PF00133 tRNA-synt_1 # Pfam PF06827 zf-FPG_IleRS # Pfam PF08264 Anticodon_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SYI_ECOLI Isoleucine--tRNA ligase # RefSeq NP_414567 NC_000913.3 # RefSeq WP_001286857 NZ_LN832404.1 # SIMILARITY Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION SYI_ECOLI Cytoplasm. # SUBUNIT SYI_ECOLI Monomer. # SUPFAM SSF47323 SSF47323 # SUPFAM SSF50677 SSF50677 # TIGRFAMs TIGR00392 ileS # eggNOG COG0060 LUCA # eggNOG ENOG4105C07 Bacteria BLAST swissprot:SYI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SYI_ECOLI BioCyc ECOL316407:JW0024-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0024-MONOMER BioCyc EcoCyc:ILES-MONOMER http://biocyc.org/getid?id=EcoCyc:ILES-MONOMER BioCyc MetaCyc:ILES-MONOMER http://biocyc.org/getid?id=MetaCyc:ILES-MONOMER COG COG0060 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0060 DIP DIP-10017N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10017N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0014-5793(84)81060-1 http://dx.doi.org/10.1016/0014-5793(84)81060-1 DOI 10.1016/S1097-2765(00)80203-8 http://dx.doi.org/10.1016/S1097-2765(00)80203-8 DOI 10.1016/S1097-2765(02)00449-5 http://dx.doi.org/10.1016/S1097-2765(02)00449-5 DOI 10.1021/bi0004798 http://dx.doi.org/10.1021/bi0004798 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.012611299 http://dx.doi.org/10.1073/pnas.012611299 DOI 10.1073/pnas.0237335100 http://dx.doi.org/10.1073/pnas.0237335100 DOI 10.1073/pnas.81.12.3708 http://dx.doi.org/10.1073/pnas.81.12.3708 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1126/science.280.5363.578 http://dx.doi.org/10.1126/science.280.5363.578 DOI 10.1126/science.3282306 http://dx.doi.org/10.1126/science.3282306 DOI 10.1126/science.6390679 http://dx.doi.org/10.1126/science.6390679 EC_number EC:6.1.1.5 http://www.genome.jp/dbget-bin/www_bget?EC:6.1.1.5 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K01990 http://www.ebi.ac.uk/ena/data/view/K01990 EMBL M10428 http://www.ebi.ac.uk/ena/data/view/M10428 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X00776 http://www.ebi.ac.uk/ena/data/view/X00776 ENZYME 6.1.1.5 http://enzyme.expasy.org/EC/6.1.1.5 EchoBASE EB0487 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0487 EcoGene EG10492 http://www.ecogene.org/geneInfo.php?eg_id=EG10492 EnsemblBacteria AAC73137 http://www.ensemblgenomes.org/id/AAC73137 EnsemblBacteria AAC73137 http://www.ensemblgenomes.org/id/AAC73137 EnsemblBacteria BAB96595 http://www.ensemblgenomes.org/id/BAB96595 EnsemblBacteria BAB96595 http://www.ensemblgenomes.org/id/BAB96595 EnsemblBacteria BAB96595 http://www.ensemblgenomes.org/id/BAB96595 EnsemblBacteria b0026 http://www.ensemblgenomes.org/id/b0026 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000049 GO_function GO:0002161 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002161 GO_function GO:0004822 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004822 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_process GO:0006428 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006428 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.10.730.10 http://www.cathdb.info/version/latest/superfamily/1.10.730.10 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 Gene3D 3.90.740.10 http://www.cathdb.info/version/latest/superfamily/3.90.740.10 GeneID 944761 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944761 HAMAP MF_02002 http://hamap.expasy.org/unirule/MF_02002 HOGENOM HOG000246402 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000246402&db=HOGENOM6 InParanoid P00956 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00956 IntAct P00956 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00956* IntEnz 6.1.1.5 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.1.1.5 InterPro IPR001412 http://www.ebi.ac.uk/interpro/entry/IPR001412 InterPro IPR002300 http://www.ebi.ac.uk/interpro/entry/IPR002300 InterPro IPR002301 http://www.ebi.ac.uk/interpro/entry/IPR002301 InterPro IPR009008 http://www.ebi.ac.uk/interpro/entry/IPR009008 InterPro IPR009080 http://www.ebi.ac.uk/interpro/entry/IPR009080 InterPro IPR010663 http://www.ebi.ac.uk/interpro/entry/IPR010663 InterPro IPR013155 http://www.ebi.ac.uk/interpro/entry/IPR013155 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 InterPro IPR023585 http://www.ebi.ac.uk/interpro/entry/IPR023585 InterPro IPR033708 http://www.ebi.ac.uk/interpro/entry/IPR033708 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW0024 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0024 KEGG_Gene eco:b0026 http://www.genome.jp/dbget-bin/www_bget?eco:b0026 KEGG_Orthology KO:K01870 http://www.genome.jp/dbget-bin/www_bget?KO:K01870 KEGG_Pathway ko00970 http://www.genome.jp/kegg-bin/show_pathway?ko00970 KEGG_Reaction rn:R03656 http://www.genome.jp/dbget-bin/www_bget?rn:R03656 MINT MINT-1232480 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1232480 OMA PIPFFLH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PIPFFLH PRINTS PR00984 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00984 PROSITE PS00178 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00178 PSORT swissprot:SYI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SYI_ECOLI PSORT-B swissprot:SYI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SYI_ECOLI PSORT2 swissprot:SYI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SYI_ECOLI Pfam PF00133 http://pfam.xfam.org/family/PF00133 Pfam PF06827 http://pfam.xfam.org/family/PF06827 Pfam PF08264 http://pfam.xfam.org/family/PF08264 Phobius swissprot:SYI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SYI_ECOLI PhylomeDB P00956 http://phylomedb.org/?seqid=P00956 ProteinModelPortal P00956 http://www.proteinmodelportal.org/query/uniprot/P00956 PubMed 10549284 http://www.ncbi.nlm.nih.gov/pubmed/10549284 PubMed 10889024 http://www.ncbi.nlm.nih.gov/pubmed/10889024 PubMed 11782529 http://www.ncbi.nlm.nih.gov/pubmed/11782529 PubMed 11864608 http://www.ncbi.nlm.nih.gov/pubmed/11864608 PubMed 12515858 http://www.ncbi.nlm.nih.gov/pubmed/12515858 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 2985604 http://www.ncbi.nlm.nih.gov/pubmed/2985604 PubMed 3282306 http://www.ncbi.nlm.nih.gov/pubmed/3282306 PubMed 6374664 http://www.ncbi.nlm.nih.gov/pubmed/6374664 PubMed 6378662 http://www.ncbi.nlm.nih.gov/pubmed/6378662 PubMed 6390679 http://www.ncbi.nlm.nih.gov/pubmed/6390679 PubMed 7929087 http://www.ncbi.nlm.nih.gov/pubmed/7929087 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9554847 http://www.ncbi.nlm.nih.gov/pubmed/9554847 RefSeq NP_414567 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414567 RefSeq WP_001286857 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001286857 STRING 511145.b0026 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0026&targetmode=cogs STRING COG0060 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0060&targetmode=cogs SUPFAM SSF47323 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47323 SUPFAM SSF50677 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50677 TIGRFAMs TIGR00392 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00392 UniProtKB SYI_ECOLI http://www.uniprot.org/uniprot/SYI_ECOLI UniProtKB-AC P00956 http://www.uniprot.org/uniprot/P00956 charge swissprot:SYI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SYI_ECOLI eggNOG COG0060 http://eggnogapi.embl.de/nog_data/html/tree/COG0060 eggNOG ENOG4105C07 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C07 epestfind swissprot:SYI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SYI_ECOLI garnier swissprot:SYI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SYI_ECOLI helixturnhelix swissprot:SYI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SYI_ECOLI hmoment swissprot:SYI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SYI_ECOLI iep swissprot:SYI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SYI_ECOLI inforesidue swissprot:SYI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SYI_ECOLI octanol swissprot:SYI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SYI_ECOLI pepcoil swissprot:SYI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SYI_ECOLI pepdigest swissprot:SYI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SYI_ECOLI pepinfo swissprot:SYI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SYI_ECOLI pepnet swissprot:SYI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SYI_ECOLI pepstats swissprot:SYI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SYI_ECOLI pepwheel swissprot:SYI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SYI_ECOLI pepwindow swissprot:SYI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SYI_ECOLI sigcleave swissprot:SYI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SYI_ECOLI ## Database ID URL or Descriptions # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG14420 ymjC # Gene3D 3.40.50.720 -; 1. # InterPro IPR016040 NAD(P)-bd_dom # Organism YMJC_ECOLI Escherichia coli (strain K12) # PATRIC 48661951 VBIEscCol107702_1339 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YMJC_ECOLI Putative uncharacterized protein YmjC # RefSeq WP_000800171 NZ_LN832404.1 # SUPFAM SSF51735 SSF51735 # eggNOG COG0702 LUCA BLAST swissprot:YMJC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YMJC_ECOLI BioCyc ECOL316407:JW5960-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5960-MONOMER BioCyc EcoCyc:MONOMER0-2668 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2668 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14420 http://www.ecogene.org/geneInfo.php?eg_id=EG14420 EnsemblBacteria BAE76402 http://www.ensemblgenomes.org/id/BAE76402 EnsemblBacteria BAE76402 http://www.ensemblgenomes.org/id/BAE76402 EnsemblBacteria BAE76402 http://www.ensemblgenomes.org/id/BAE76402 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 KEGG_Gene ecj:JW5960 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5960 PSORT swissprot:YMJC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YMJC_ECOLI PSORT-B swissprot:YMJC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YMJC_ECOLI PSORT2 swissprot:YMJC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YMJC_ECOLI Phobius swissprot:YMJC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YMJC_ECOLI ProteinModelPortal Q2EER5 http://www.proteinmodelportal.org/query/uniprot/Q2EER5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000800171 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000800171 SMR Q2EER5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q2EER5 STRING 316407.85674906 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85674906&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB YMJC_ECOLI http://www.uniprot.org/uniprot/YMJC_ECOLI UniProtKB-AC Q2EER5 http://www.uniprot.org/uniprot/Q2EER5 charge swissprot:YMJC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YMJC_ECOLI eggNOG COG0702 http://eggnogapi.embl.de/nog_data/html/tree/COG0702 epestfind swissprot:YMJC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YMJC_ECOLI garnier swissprot:YMJC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YMJC_ECOLI helixturnhelix swissprot:YMJC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YMJC_ECOLI hmoment swissprot:YMJC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YMJC_ECOLI iep swissprot:YMJC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YMJC_ECOLI inforesidue swissprot:YMJC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YMJC_ECOLI octanol swissprot:YMJC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YMJC_ECOLI pepcoil swissprot:YMJC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YMJC_ECOLI pepdigest swissprot:YMJC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YMJC_ECOLI pepinfo swissprot:YMJC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YMJC_ECOLI pepnet swissprot:YMJC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YMJC_ECOLI pepstats swissprot:YMJC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YMJC_ECOLI pepwheel swissprot:YMJC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YMJC_ECOLI pepwindow swissprot:YMJC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YMJC_ECOLI sigcleave swissprot:YMJC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YMJC_ECOLI ## Database ID URL or Descriptions # AltName CODA_ECOLI Cytosine aminohydrolase # AltName Isoguanine deaminase {ECO:0000303|PubMed 21604715} # BIOPHYSICOCHEMICAL PROPERTIES CODA_ECOLI Kinetic parameters KM=0.22 mM for cytosine {ECO 0000269|PubMed 8226944}; KM=0.2 mM for cytosine {ECO 0000269|PubMed 15381761}; KM=3.3 mM for 5-fluorocytosine {ECO 0000269|PubMed 15381761}; KM=0.97 mM for cytosine {ECO 0000269|PubMed 21545144}; KM=0.46 mM for isocytosine {ECO 0000269|PubMed 21545144}; KM=25 mM for creatinine {ECO 0000269|PubMed 21545144}; KM=4.1 mM for 3-oxauracil {ECO 0000269|PubMed 21545144}; KM=72 uM for isoguanine {ECO 0000269|PubMed 21604715}; KM=302 uM for cytosine {ECO 0000269|PubMed 21604715}; Note=kcat is 185 sec(-1) for the deamination of cytosine using Fe(2+) as cofactor, kcat is 92 sec(-1) using Mn(2+) as cofactor, kcat is 52 sec(-1) using Co(2+) as cofactor, and kcat is 32 sec(-1) using Zn(2+) as cofactor (PubMed 8226944). kcat is 165 sec(-1) for the deamination of cytosine and 75.6 sec(-1) for the deamination of 5-fluorocytosine (PubMed 15381761). kcat is 132 sec(-1) for the deamination of cytosine, 5.1 sec(-1) for the deamination of isocytosine, 5.6 sec(-1) for the deamination of creatinine and 2.3 sec(-1) for the hydrolysis of 3-oxauracil (PubMed 21545144). kcat is 45 sec(-1) for the deamination of cytosine and 49 sec(-1) for the deamination of isoguanine at pH 7.7 (PubMed 21604715). {ECO 0000269|PubMed 15381761, ECO 0000269|PubMed 21545144, ECO 0000269|PubMed 21604715, ECO 0000269|PubMed 8226944}; pH dependence Activity is lost under pH 5 but not affected up to pH 10. {ECO 0000269|PubMed 21545144}; # BIOTECHNOLOGY CODA_ECOLI Cytosine deaminase is being explored for use as a suicide gene for cancer gene therapy. The cytosine deaminase/5- fluorouracil combined therapy has been used successfully for a variety of animal tumor models and is currently under investigation for the treatment of human cancers. {ECO 0000269|PubMed 19487291, ECO 0000303|PubMed 25338741, ECO 0000305|PubMed 15381761}. # BRENDA 3.5.4 2026 # BioGrid 4259813 4 # CATALYTIC ACTIVITY CODA_ECOLI Cytosine + H(2)O = uracil + NH(3). {ECO 0000269|PubMed 15381761, ECO 0000269|PubMed 21545144, ECO 0000269|PubMed 21604715, ECO 0000269|PubMed 8226944}. # CATALYTIC ACTIVITY Isoguanine + H(2)O = xanthine + NH(3). {ECO:0000269|PubMed 21604715}. # COFACTOR CODA_ECOLI Name=Fe(2+); Xref=ChEBI CHEBI 29033; Evidence={ECO 0000269|PubMed 21545144, ECO 0000269|PubMed 8226944}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 8226944}; Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 21545144, ECO 0000269|PubMed 8226944}; Note=The purified enzyme contains a mixture of Fe(2+) and Zn(2+) bound in the active site, and a single equivalent of metal is required for full catalytic activity. After removal of the metal, the reconstitution of the enzyme with Fe(2+) gives the highest activity, followed by Mn(2+), and, to a much lesser extent, Co(2+) and Zn(2+). {ECO 0000269|PubMed 21545144, ECO 0000269|PubMed 8226944}; # DISRUPTION PHENOTYPE Cells lacking this gene have less than 1% of the isoguanine deaminase activity of the wild-type strain. {ECO:0000269|PubMed 21604715}. # ENZYME REGULATION CODA_ECOLI Fe(2+)-CDase is rapidly inactivated by H(2)O(2), whereas Mn(2+)-CDase, Co(2+)-CDase, and Zn(2+)-CDase are not inactivated by H(2)O(2). CDase is also inhibited by excess divalent cations (PubMed 8226944). Phosphonocytosine, a mimic of the tetrahedral reaction intermediate, inhibits the deamination of cytosine with a Ki of 52 nM (PubMed 21545144). {ECO 0000269|PubMed 21545144, ECO 0000269|PubMed 8226944}. # EcoGene EG11326 codA # FUNCTION CODA_ECOLI Catalyzes the hydrolytic deamination of cytosine to uracil. Is involved in the pyrimidine salvage pathway, which allows the cell to utilize cytosine for pyrimidine nucleotide synthesis. Is also able to catalyze deamination of isoguanine, a mutagenic oxidation product of adenine in DNA, and of isocytosine. To a lesser extent, also catalyzes the conversion of 5- fluorocytosine (5FC) to 5-fluorouracil (5FU); this activity allows the formation of a cytotoxic chemotherapeutic agent from a non- cytotoxic precursor. {ECO 0000269|PubMed 15381761, ECO 0000269|PubMed 21545144, ECO 0000269|PubMed 21604715, ECO 0000269|PubMed 8226944}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0004131 cytosine deaminase activity; IDA:EcoCyc. # GO_function GO:0008198 ferrous iron binding; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_function GO:0035888 isoguanine deaminase activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0006209 cytosine catabolic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 2.30.40.10 -; 1. # INTERACTION CODA_ECOLI Self; NbExp=3; IntAct=EBI-559181, EBI-559181; # IntAct P25524 6 # InterPro IPR011059 Metal-dep_hydrolase_composite # InterPro IPR013108 Amidohydro_3 # InterPro IPR032466 Metal_Hydrolase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00240 Pyrimidine metabolism # KEGG_Pathway ko00330 Arginine and proline metabolism # Organism CODA_ECOLI Escherichia coli (strain K12) # PATRIC 32115805 VBIEscCol129921_0344 # PDB 1K6W X-ray; 1.75 A; A=2-427 # PDB 1K70 X-ray; 1.80 A; A=2-427 # PDB 1R9X X-ray; 1.58 A; A=2-427 # PDB 1R9Y X-ray; 1.57 A; A=2-427 # PDB 1R9Z X-ray; 1.32 A; A=2-427 # PDB 1RA0 X-ray; 1.12 A; A=2-427 # PDB 1RA5 X-ray; 1.40 A; A=2-427 # PDB 1RAK X-ray; 1.32 A; A=2-427 # PDB 3G77 X-ray; 1.80 A; A=5-427 # PDB 3O7U X-ray; 1.71 A; A=1-427 # PDB 3R0D X-ray; 1.50 A; A=1-427 # PDB 3RN6 X-ray; 2.26 A; A=1-427 # PIR S22662 S22662 # Pfam PF07969 Amidohydro_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CODA_ECOLI Cytosine deaminase {ECO 0000303|PubMed 1640834, ECO 0000303|PubMed 8226944} # RefSeq NP_414871 NC_000913.3 # RefSeq WP_001301240 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18061.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the cytosine deaminase family. {ECO 0000305}. # SUBUNIT Homohexamer. {ECO:0000269|PubMed 11679731}. # SUPFAM SSF51338 SSF51338 # SUPFAM SSF51556 SSF51556 # eggNOG COG0402 LUCA # eggNOG ENOG4105DZC Bacteria BLAST swissprot:CODA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CODA_ECOLI BioCyc ECOL316407:JW0328-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0328-MONOMER BioCyc EcoCyc:CYTDEAM-MONOMER http://biocyc.org/getid?id=EcoCyc:CYTDEAM-MONOMER BioCyc MetaCyc:CYTDEAM-MONOMER http://biocyc.org/getid?id=MetaCyc:CYTDEAM-MONOMER COG COG0402 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0402 DIP DIP-9306N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9306N DOI 10.1006/jmbi.2001.5277 http://dx.doi.org/10.1006/jmbi.2001.5277 DOI 10.1021/bi200483k http://dx.doi.org/10.1021/bi200483k DOI 10.1021/bi200680y http://dx.doi.org/10.1021/bi200680y DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/protein/gzh074 http://dx.doi.org/10.1093/protein/gzh074 DOI 10.1107/S0907444901011064 http://dx.doi.org/10.1107/S0907444901011064 DOI 10.1111/j.1365-2958.1992.tb00854.x http://dx.doi.org/10.1111/j.1365-2958.1992.tb00854.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1158/0008-5472.CAN-09-0615 http://dx.doi.org/10.1158/0008-5472.CAN-09-0615 DOI 10.1208/s12248-014-9675-7 http://dx.doi.org/10.1208/s12248-014-9675-7 EC_number EC:3.5.4.- {ECO:0000269|PubMed:21604715} http://www.genome.jp/dbget-bin/www_bget?EC:3.5.4.- {ECO:0000269|PubMed:21604715} EC_number EC:3.5.4.1 {ECO:0000269|PubMed:15381761, ECO:0000269|PubMed:21545144, ECO:0000269|PubMed:21604715, ECO:0000269|PubMed:8226944} http://www.genome.jp/dbget-bin/www_bget?EC:3.5.4.1 {ECO:0000269|PubMed:15381761, ECO:0000269|PubMed:21545144, ECO:0000269|PubMed:21604715, ECO:0000269|PubMed:8226944} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL S56903 http://www.ebi.ac.uk/ena/data/view/S56903 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EMBL X63656 http://www.ebi.ac.uk/ena/data/view/X63656 ENZYME 3.5.4.- {ECO:0000269|PubMed:21604715} http://enzyme.expasy.org/EC/3.5.4.- {ECO:0000269|PubMed:21604715} ENZYME 3.5.4.1 {ECO:0000269|PubMed:15381761, ECO:0000269|PubMed:21545144, ECO:0000269|PubMed:21604715, ECO:0000269|PubMed:8226944} http://enzyme.expasy.org/EC/3.5.4.1 {ECO:0000269|PubMed:15381761, ECO:0000269|PubMed:21545144, ECO:0000269|PubMed:21604715, ECO:0000269|PubMed:8226944} EchoBASE EB1302 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1302 EcoGene EG11326 http://www.ecogene.org/geneInfo.php?eg_id=EG11326 EnsemblBacteria AAC73440 http://www.ensemblgenomes.org/id/AAC73440 EnsemblBacteria AAC73440 http://www.ensemblgenomes.org/id/AAC73440 EnsemblBacteria BAE76119 http://www.ensemblgenomes.org/id/BAE76119 EnsemblBacteria BAE76119 http://www.ensemblgenomes.org/id/BAE76119 EnsemblBacteria BAE76119 http://www.ensemblgenomes.org/id/BAE76119 EnsemblBacteria b0337 http://www.ensemblgenomes.org/id/b0337 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004131 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004131 GO_function GO:0008198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008198 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0035888 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035888 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0006209 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006209 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 2.30.40.10 http://www.cathdb.info/version/latest/superfamily/2.30.40.10 GeneID 944996 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944996 HOGENOM HOG000184778 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000184778&db=HOGENOM6 InParanoid P25524 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P25524 IntAct P25524 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P25524* IntEnz 3.5.4.- {ECO:0000269|PubMed:21604715} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.4.- {ECO:0000269|PubMed:21604715} IntEnz 3.5.4.1 {ECO:0000269|PubMed:15381761, ECO:0000269|PubMed:21545144, ECO:0000269|PubMed:21604715, ECO:0000269|PubMed:8226944} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.4.1 {ECO:0000269|PubMed:15381761, ECO:0000269|PubMed:21545144, ECO:0000269|PubMed:21604715, ECO:0000269|PubMed:8226944} InterPro IPR011059 http://www.ebi.ac.uk/interpro/entry/IPR011059 InterPro IPR013108 http://www.ebi.ac.uk/interpro/entry/IPR013108 InterPro IPR032466 http://www.ebi.ac.uk/interpro/entry/IPR032466 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0328 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0328 KEGG_Gene eco:b0337 http://www.genome.jp/dbget-bin/www_bget?eco:b0337 KEGG_Orthology KO:K01485 http://www.genome.jp/dbget-bin/www_bget?KO:K01485 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Pathway ko00330 http://www.genome.jp/kegg-bin/show_pathway?ko00330 KEGG_Reaction rn:R00974 http://www.genome.jp/dbget-bin/www_bget?rn:R00974 KEGG_Reaction rn:R01411 http://www.genome.jp/dbget-bin/www_bget?rn:R01411 KEGG_Reaction rn:R02922 http://www.genome.jp/dbget-bin/www_bget?rn:R02922 MINT MINT-1307853 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1307853 OMA AFPQDGY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AFPQDGY PDB 1K6W http://www.ebi.ac.uk/pdbe-srv/view/entry/1K6W PDB 1K70 http://www.ebi.ac.uk/pdbe-srv/view/entry/1K70 PDB 1R9X http://www.ebi.ac.uk/pdbe-srv/view/entry/1R9X PDB 1R9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/1R9Y PDB 1R9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/1R9Z PDB 1RA0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1RA0 PDB 1RA5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1RA5 PDB 1RAK http://www.ebi.ac.uk/pdbe-srv/view/entry/1RAK PDB 3G77 http://www.ebi.ac.uk/pdbe-srv/view/entry/3G77 PDB 3O7U http://www.ebi.ac.uk/pdbe-srv/view/entry/3O7U PDB 3R0D http://www.ebi.ac.uk/pdbe-srv/view/entry/3R0D PDB 3RN6 http://www.ebi.ac.uk/pdbe-srv/view/entry/3RN6 PDBsum 1K6W http://www.ebi.ac.uk/pdbsum/1K6W PDBsum 1K70 http://www.ebi.ac.uk/pdbsum/1K70 PDBsum 1R9X http://www.ebi.ac.uk/pdbsum/1R9X PDBsum 1R9Y http://www.ebi.ac.uk/pdbsum/1R9Y PDBsum 1R9Z http://www.ebi.ac.uk/pdbsum/1R9Z PDBsum 1RA0 http://www.ebi.ac.uk/pdbsum/1RA0 PDBsum 1RA5 http://www.ebi.ac.uk/pdbsum/1RA5 PDBsum 1RAK http://www.ebi.ac.uk/pdbsum/1RAK PDBsum 3G77 http://www.ebi.ac.uk/pdbsum/3G77 PDBsum 3O7U http://www.ebi.ac.uk/pdbsum/3O7U PDBsum 3R0D http://www.ebi.ac.uk/pdbsum/3R0D PDBsum 3RN6 http://www.ebi.ac.uk/pdbsum/3RN6 PSORT swissprot:CODA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CODA_ECOLI PSORT-B swissprot:CODA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CODA_ECOLI PSORT2 swissprot:CODA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CODA_ECOLI Pfam PF07969 http://pfam.xfam.org/family/PF07969 Phobius swissprot:CODA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CODA_ECOLI PhylomeDB P25524 http://phylomedb.org/?seqid=P25524 ProteinModelPortal P25524 http://www.proteinmodelportal.org/query/uniprot/P25524 PubMed 11679731 http://www.ncbi.nlm.nih.gov/pubmed/11679731 PubMed 11812140 http://www.ncbi.nlm.nih.gov/pubmed/11812140 PubMed 15381761 http://www.ncbi.nlm.nih.gov/pubmed/15381761 PubMed 1640834 http://www.ncbi.nlm.nih.gov/pubmed/1640834 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19487291 http://www.ncbi.nlm.nih.gov/pubmed/19487291 PubMed 21545144 http://www.ncbi.nlm.nih.gov/pubmed/21545144 PubMed 21604715 http://www.ncbi.nlm.nih.gov/pubmed/21604715 PubMed 25338741 http://www.ncbi.nlm.nih.gov/pubmed/25338741 PubMed 8226944 http://www.ncbi.nlm.nih.gov/pubmed/8226944 PubMed 8450832 http://www.ncbi.nlm.nih.gov/pubmed/8450832 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414871 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414871 RefSeq WP_001301240 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001301240 SMR P25524 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P25524 STRING 511145.b0337 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0337&targetmode=cogs STRING COG0402 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0402&targetmode=cogs SUPFAM SSF51338 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51338 SUPFAM SSF51556 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51556 UniProtKB CODA_ECOLI http://www.uniprot.org/uniprot/CODA_ECOLI UniProtKB-AC P25524 http://www.uniprot.org/uniprot/P25524 charge swissprot:CODA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CODA_ECOLI eggNOG COG0402 http://eggnogapi.embl.de/nog_data/html/tree/COG0402 eggNOG ENOG4105DZC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DZC epestfind swissprot:CODA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CODA_ECOLI garnier swissprot:CODA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CODA_ECOLI helixturnhelix swissprot:CODA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CODA_ECOLI hmoment swissprot:CODA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CODA_ECOLI iep swissprot:CODA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CODA_ECOLI inforesidue swissprot:CODA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CODA_ECOLI octanol swissprot:CODA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CODA_ECOLI pepcoil swissprot:CODA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CODA_ECOLI pepdigest swissprot:CODA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CODA_ECOLI pepinfo swissprot:CODA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CODA_ECOLI pepnet swissprot:CODA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CODA_ECOLI pepstats swissprot:CODA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CODA_ECOLI pepwheel swissprot:CODA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CODA_ECOLI pepwindow swissprot:CODA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CODA_ECOLI sigcleave swissprot:CODA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CODA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260107 6 # EcoGene EG10761 prfA # FUNCTION RF1_ECOLI Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0016149 translation release factor activity, codon specific; IDA:EcoCyc. # GO_function GO:0043022 ribosome binding; IDA:EcoCyc. # GO_process GO:0006415 translational termination; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008135 translation factor activity, RNA binding # GOslim_process GO:0008150 biological_process # Gene3D 3.30.160.20 -; 1. # HAMAP MF_00093 Rel_fac_1 # IntAct P0A7I0 13 # InterPro IPR000352 Pep_chain_release_fac_I_II # InterPro IPR004373 PrfA # InterPro IPR005139 PCRF # InterPro IPR014720 dsRBD_dom # KEGG_Brite ko03012 Translation factors # Organism RF1_ECOLI Escherichia coli (strain K12) # PATRIC 32117674 VBIEscCol129921_1259 # PDB 2B3T X-ray; 3.10 A; B=1-356 # PDB 5J30 X-ray; 3.20 A; QY/XY=1-360 # PDB 5J3C X-ray; 3.04 A; QY/XY=1-360 # PDB 5J4D X-ray; 3.10 A; JA/OC=1-360 # PIR H64867 FCECR1 # PROSITE PS00745 RF_PROK_I # PTM RF1_ECOLI Methylated by PrmC. Methylation increases the termination efficiency of RF1. {ECO 0000269|PubMed 11118225, ECO 0000269|PubMed 11805295, ECO 0000269|PubMed 11847124}. # Pfam PF00472 RF-1 # Pfam PF03462 PCRF # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RF1_ECOLI Peptide chain release factor 1 # RefSeq NP_415729 NC_000913.3 # RefSeq WP_000804726 NZ_LN832404.1 # SIMILARITY Belongs to the prokaryotic/mitochondrial release factor family. {ECO 0000305}. # SMART SM00937 PCRF # SUBCELLULAR LOCATION RF1_ECOLI Cytoplasm. # TIGRFAMs TIGR00019 prfA # eggNOG COG0216 LUCA # eggNOG ENOG4105C8K Bacteria BLAST swissprot:RF1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RF1_ECOLI BioCyc ECOL316407:JW1202-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1202-MONOMER BioCyc EcoCyc:EG10761-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10761-MONOMER COG COG0216 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0216 DIP DIP-35936N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35936N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0378-1119(89)90046-2 http://dx.doi.org/10.1016/0378-1119(89)90046-2 DOI 10.1016/0378-1119(94)00805-3 http://dx.doi.org/10.1016/0378-1119(94)00805-3 DOI 10.1016/j.molcel.2005.10.025 http://dx.doi.org/10.1016/j.molcel.2005.10.025 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.032488499 http://dx.doi.org/10.1073/pnas.032488499 DOI 10.1073/pnas.82.11.3616 http://dx.doi.org/10.1073/pnas.82.11.3616 DOI 10.1074/jbc.M706076200 http://dx.doi.org/10.1074/jbc.M706076200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/emboj/19.24.6900 http://dx.doi.org/10.1093/emboj/19.24.6900 DOI 10.1093/emboj/21.4.769 http://dx.doi.org/10.1093/emboj/21.4.769 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D28567 http://www.ebi.ac.uk/ena/data/view/D28567 EMBL M11519 http://www.ebi.ac.uk/ena/data/view/M11519 EMBL M25323 http://www.ebi.ac.uk/ena/data/view/M25323 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18555 http://www.ebi.ac.uk/ena/data/view/U18555 EchoBASE EB0754 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0754 EcoGene EG10761 http://www.ecogene.org/geneInfo.php?eg_id=EG10761 EnsemblBacteria AAC74295 http://www.ensemblgenomes.org/id/AAC74295 EnsemblBacteria AAC74295 http://www.ensemblgenomes.org/id/AAC74295 EnsemblBacteria BAA36069 http://www.ensemblgenomes.org/id/BAA36069 EnsemblBacteria BAA36069 http://www.ensemblgenomes.org/id/BAA36069 EnsemblBacteria BAA36069 http://www.ensemblgenomes.org/id/BAA36069 EnsemblBacteria b1211 http://www.ensemblgenomes.org/id/b1211 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0016149 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016149 GO_function GO:0043022 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043022 GO_process GO:0006415 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006415 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008135 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008135 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.30.160.20 http://www.cathdb.info/version/latest/superfamily/3.30.160.20 GeneID 949002 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949002 HAMAP MF_00093 http://hamap.expasy.org/unirule/MF_00093 HOGENOM HOG000074815 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000074815&db=HOGENOM6 InParanoid P0A7I0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7I0 IntAct P0A7I0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7I0* InterPro IPR000352 http://www.ebi.ac.uk/interpro/entry/IPR000352 InterPro IPR004373 http://www.ebi.ac.uk/interpro/entry/IPR004373 InterPro IPR005139 http://www.ebi.ac.uk/interpro/entry/IPR005139 InterPro IPR014720 http://www.ebi.ac.uk/interpro/entry/IPR014720 KEGG_Brite ko03012 http://www.genome.jp/dbget-bin/www_bget?ko03012 KEGG_Gene ecj:JW1202 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1202 KEGG_Gene eco:b1211 http://www.genome.jp/dbget-bin/www_bget?eco:b1211 KEGG_Orthology KO:K02835 http://www.genome.jp/dbget-bin/www_bget?KO:K02835 MINT MINT-1219241 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1219241 OMA WRKVQDD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WRKVQDD PDB 2B3T http://www.ebi.ac.uk/pdbe-srv/view/entry/2B3T PDB 5J30 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J30 PDB 5J3C http://www.ebi.ac.uk/pdbe-srv/view/entry/5J3C PDB 5J4D http://www.ebi.ac.uk/pdbe-srv/view/entry/5J4D PDBsum 2B3T http://www.ebi.ac.uk/pdbsum/2B3T PDBsum 5J30 http://www.ebi.ac.uk/pdbsum/5J30 PDBsum 5J3C http://www.ebi.ac.uk/pdbsum/5J3C PDBsum 5J4D http://www.ebi.ac.uk/pdbsum/5J4D PROSITE PS00745 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00745 PSORT swissprot:RF1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RF1_ECOLI PSORT-B swissprot:RF1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RF1_ECOLI PSORT2 swissprot:RF1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RF1_ECOLI Pfam PF00472 http://pfam.xfam.org/family/PF00472 Pfam PF03462 http://pfam.xfam.org/family/PF03462 Phobius swissprot:RF1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RF1_ECOLI PhylomeDB P0A7I0 http://phylomedb.org/?seqid=P0A7I0 ProteinModelPortal P0A7I0 http://www.proteinmodelportal.org/query/uniprot/P0A7I0 PubMed 11118225 http://www.ncbi.nlm.nih.gov/pubmed/11118225 PubMed 11805295 http://www.ncbi.nlm.nih.gov/pubmed/11805295 PubMed 11847124 http://www.ncbi.nlm.nih.gov/pubmed/11847124 PubMed 16364916 http://www.ncbi.nlm.nih.gov/pubmed/16364916 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17932046 http://www.ncbi.nlm.nih.gov/pubmed/17932046 PubMed 2548996 http://www.ncbi.nlm.nih.gov/pubmed/2548996 PubMed 2684779 http://www.ncbi.nlm.nih.gov/pubmed/2684779 PubMed 3049538 http://www.ncbi.nlm.nih.gov/pubmed/3049538 PubMed 3889910 http://www.ncbi.nlm.nih.gov/pubmed/3889910 PubMed 7543480 http://www.ncbi.nlm.nih.gov/pubmed/7543480 PubMed 7883187 http://www.ncbi.nlm.nih.gov/pubmed/7883187 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_415729 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415729 RefSeq WP_000804726 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000804726 SMART SM00937 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00937 SMR P0A7I0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7I0 STRING 511145.b1211 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1211&targetmode=cogs STRING COG0216 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0216&targetmode=cogs TIGRFAMs TIGR00019 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00019 UniProtKB RF1_ECOLI http://www.uniprot.org/uniprot/RF1_ECOLI UniProtKB-AC P0A7I0 http://www.uniprot.org/uniprot/P0A7I0 charge swissprot:RF1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RF1_ECOLI eggNOG COG0216 http://eggnogapi.embl.de/nog_data/html/tree/COG0216 eggNOG ENOG4105C8K http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C8K epestfind swissprot:RF1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RF1_ECOLI garnier swissprot:RF1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RF1_ECOLI helixturnhelix swissprot:RF1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RF1_ECOLI hmoment swissprot:RF1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RF1_ECOLI iep swissprot:RF1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RF1_ECOLI inforesidue swissprot:RF1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RF1_ECOLI octanol swissprot:RF1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RF1_ECOLI pepcoil swissprot:RF1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RF1_ECOLI pepdigest swissprot:RF1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RF1_ECOLI pepinfo swissprot:RF1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RF1_ECOLI pepnet swissprot:RF1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RF1_ECOLI pepstats swissprot:RF1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RF1_ECOLI pepwheel swissprot:RF1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RF1_ECOLI pepwindow swissprot:RF1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RF1_ECOLI sigcleave swissprot:RF1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RF1_ECOLI ## Database ID URL or Descriptions # BioGrid 4261607 16 # COFACTOR YCBL_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000250|UniProtKB Q16775}; Note=Binds 2 Zn(2+) ions per subunit. {ECO 0000250|UniProtKB Q16775}; # EcoGene EG13704 ycbL # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004416 hydroxyacylglutathione hydrolase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.60.15.10 -; 1. # IntAct P75849 4 # InterPro IPR001279 Metallo-B-lactamas # Organism YCBL_ECOLI Escherichia coli (strain K12) # PATRIC 32117067 VBIEscCol129921_0958 # PIR F64832 F64832 # Pfam PF00753 Lactamase_B # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCBL_ECOLI Uncharacterized protein YcbL # RefSeq NP_415447 NC_000913.3 # RefSeq WP_001109486 NZ_LN832404.1 # SIMILARITY Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. {ECO 0000305}. # SMART SM00849 Lactamase_B # SUPFAM SSF56281 SSF56281 # eggNOG COG0491 LUCA # eggNOG ENOG4105C5X Bacteria BLAST swissprot:YCBL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCBL_ECOLI BioCyc ECOL316407:JW0910-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0910-MONOMER BioCyc EcoCyc:G6475-MONOMER http://biocyc.org/getid?id=EcoCyc:G6475-MONOMER BioCyc MetaCyc:G6475-MONOMER http://biocyc.org/getid?id=MetaCyc:G6475-MONOMER DIP DIP-11480N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11480N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.-.-.- http://enzyme.expasy.org/EC/3.-.-.- EchoBASE EB3468 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3468 EcoGene EG13704 http://www.ecogene.org/geneInfo.php?eg_id=EG13704 EnsemblBacteria AAC74013 http://www.ensemblgenomes.org/id/AAC74013 EnsemblBacteria AAC74013 http://www.ensemblgenomes.org/id/AAC74013 EnsemblBacteria BAA35673 http://www.ensemblgenomes.org/id/BAA35673 EnsemblBacteria BAA35673 http://www.ensemblgenomes.org/id/BAA35673 EnsemblBacteria BAA35673 http://www.ensemblgenomes.org/id/BAA35673 EnsemblBacteria b0927 http://www.ensemblgenomes.org/id/b0927 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004416 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004416 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0019243 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019243 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.60.15.10 http://www.cathdb.info/version/latest/superfamily/3.60.15.10 GeneID 945551 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945551 HOGENOM HOG000058039 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000058039&db=HOGENOM6 InParanoid P75849 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75849 IntAct P75849 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75849* IntEnz 3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3 InterPro IPR001279 http://www.ebi.ac.uk/interpro/entry/IPR001279 KEGG_Gene ecj:JW0910 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0910 KEGG_Gene eco:b0927 http://www.genome.jp/dbget-bin/www_bget?eco:b0927 MINT MINT-1282138 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1282138 OMA TPDRWLE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TPDRWLE PSORT swissprot:YCBL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCBL_ECOLI PSORT-B swissprot:YCBL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCBL_ECOLI PSORT2 swissprot:YCBL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCBL_ECOLI Pfam PF00753 http://pfam.xfam.org/family/PF00753 Phobius swissprot:YCBL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCBL_ECOLI PhylomeDB P75849 http://phylomedb.org/?seqid=P75849 ProteinModelPortal P75849 http://www.proteinmodelportal.org/query/uniprot/P75849 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415447 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415447 RefSeq WP_001109486 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001109486 SMART SM00849 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00849 SMR P75849 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75849 STRING 511145.b0927 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0927&targetmode=cogs SUPFAM SSF56281 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56281 UniProtKB YCBL_ECOLI http://www.uniprot.org/uniprot/YCBL_ECOLI UniProtKB-AC P75849 http://www.uniprot.org/uniprot/P75849 charge swissprot:YCBL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCBL_ECOLI eggNOG COG0491 http://eggnogapi.embl.de/nog_data/html/tree/COG0491 eggNOG ENOG4105C5X http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C5X epestfind swissprot:YCBL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCBL_ECOLI garnier swissprot:YCBL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCBL_ECOLI helixturnhelix swissprot:YCBL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCBL_ECOLI hmoment swissprot:YCBL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCBL_ECOLI iep swissprot:YCBL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCBL_ECOLI inforesidue swissprot:YCBL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCBL_ECOLI octanol swissprot:YCBL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCBL_ECOLI pepcoil swissprot:YCBL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCBL_ECOLI pepdigest swissprot:YCBL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCBL_ECOLI pepinfo swissprot:YCBL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCBL_ECOLI pepnet swissprot:YCBL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCBL_ECOLI pepstats swissprot:YCBL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCBL_ECOLI pepwheel swissprot:YCBL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCBL_ECOLI pepwindow swissprot:YCBL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCBL_ECOLI sigcleave swissprot:YCBL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCBL_ECOLI ## Database ID URL or Descriptions # BioGrid 4263151 4 # CAUTION Could be the product of a pseudogene. The original protein is truncated by the IS5LO element which inserted near the N-terminus. {ECO 0000305}. # EcoGene EG12999 yghO # GO_function GO:0003677 DNA binding; IMP:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IMP:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IMP:EcoCyc. # GO_process GO:0044010 single-species biofilm formation; IMP:EcoCyc. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.630.30 -; 1. # InterPro IPR016181 Acyl_CoA_acyltransferase # Organism YGHO_ECOLI Escherichia coli (strain K12) # PATRIC 48665407 VBIEscCol107702_3012 # PIR C65084 C65084 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGHO_ECOLI Putative uncharacterized protein YghO # SUPFAM SSF55729 SSF55729; 2 BLAST swissprot:YGHO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGHO_ECOLI BioCyc ECOL316407:JW5848-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5848-MONOMER BioCyc EcoCyc:G7547-MONOMER http://biocyc.org/getid?id=EcoCyc:G7547-MONOMER DIP DIP-12207N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12207N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2822 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2822 EcoGene EG12999 http://www.ecogene.org/geneInfo.php?eg_id=EG12999 EnsemblBacteria BAE77042 http://www.ensemblgenomes.org/id/BAE77042 EnsemblBacteria BAE77042 http://www.ensemblgenomes.org/id/BAE77042 EnsemblBacteria BAE77042 http://www.ensemblgenomes.org/id/BAE77042 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0044010 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044010 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.630.30 http://www.cathdb.info/version/latest/superfamily/3.40.630.30 HOGENOM HOG000014460 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000014460&db=HOGENOM6 InParanoid Q46840 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46840 IntAct Q46840 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46840* InterPro IPR016181 http://www.ebi.ac.uk/interpro/entry/IPR016181 KEGG_Gene ecj:JW5848 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5848 OMA AWEKNWG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AWEKNWG PSORT swissprot:YGHO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGHO_ECOLI PSORT-B swissprot:YGHO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGHO_ECOLI PSORT2 swissprot:YGHO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGHO_ECOLI Phobius swissprot:YGHO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGHO_ECOLI PhylomeDB Q46840 http://phylomedb.org/?seqid=Q46840 ProteinModelPortal Q46840 http://www.proteinmodelportal.org/query/uniprot/Q46840 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 STRING 316407.85675789 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85675789&targetmode=cogs SUPFAM SSF55729 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55729 UniProtKB YGHO_ECOLI http://www.uniprot.org/uniprot/YGHO_ECOLI UniProtKB-AC Q46840 http://www.uniprot.org/uniprot/Q46840 charge swissprot:YGHO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGHO_ECOLI epestfind swissprot:YGHO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGHO_ECOLI garnier swissprot:YGHO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGHO_ECOLI helixturnhelix swissprot:YGHO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGHO_ECOLI hmoment swissprot:YGHO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGHO_ECOLI iep swissprot:YGHO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGHO_ECOLI inforesidue swissprot:YGHO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGHO_ECOLI octanol swissprot:YGHO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGHO_ECOLI pepcoil swissprot:YGHO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGHO_ECOLI pepdigest swissprot:YGHO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGHO_ECOLI pepinfo swissprot:YGHO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGHO_ECOLI pepnet swissprot:YGHO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGHO_ECOLI pepstats swissprot:YGHO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGHO_ECOLI pepwheel swissprot:YGHO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGHO_ECOLI pepwindow swissprot:YGHO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGHO_ECOLI sigcleave swissprot:YGHO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGHO_ECOLI ## Database ID URL or Descriptions # AltName CYOA_ECOLI Cytochrome b562-o complex subunit II # AltName CYOA_ECOLI Cytochrome o ubiquinol oxidase subunit 2 # AltName CYOA_ECOLI Oxidase bo(3) subunit 2 # AltName CYOA_ECOLI Ubiquinol oxidase chain B # AltName CYOA_ECOLI Ubiquinol oxidase polypeptide II # AltName CYOA_ECOLI Ubiquinol oxidase subunit 2 # BRENDA 1.10.3.10 2026 # BioGrid 4259512 241 # DISRUPTION PHENOTYPE CYOA_ECOLI Increased reduction of the ubiquinone pool (in aerobically grown minimal medium with glucose). {ECO 0000269|PubMed 19542282, ECO 0000269|PubMed 22843529}. # ENZYME REGULATION Competitively inhibited by piericidin A, non- competitively inhibited by 2-n-heptyl-4-hydroxyquinoline N-oxide, NaN(3) and KCN; 50% inhibition occurs at 2 uM, 2 uM, 15 mM and 10 uM, respectively. Inhibited by Zn(2+) and Cd(2+). {ECO:0000269|PubMed 6365921}. # EcoGene EG10178 cyoA # FUNCTION CYOA_ECOLI Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron. {ECO 0000269|PubMed 19542282, ECO 0000269|PubMed 22843529, ECO 0000269|PubMed 6308657}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoliWiki. # GO_component GO:0009319 cytochrome o ubiquinol oxidase complex; IDA:EcoCyc. # GO_component GO:0070469 respiratory chain; IEA:UniProtKB-KW. # GO_component GO:0071575 integral component of external side of plasma membrane; IDA:EcoCyc. # GO_function GO:0004129 cytochrome-c oxidase activity; IEA:InterPro. # GO_function GO:0005507 copper ion binding; IEA:InterPro. # GO_function GO:0008827 cytochrome o ubiquinol oxidase activity; IEA:InterPro. # GO_function GO:0009055 electron carrier activity; IDA:EcoCyc. # GO_function GO:0009486 cytochrome bo3 ubiquinol oxidase activity; IDA:EcoCyc. # GO_function GO:0015078 hydrogen ion transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0015453 oxidoreduction-driven active transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0048039 ubiquinone binding; IDA:EcoCyc. # GO_process GO:0009060 aerobic respiration; IMP:EcoCyc. # GO_process GO:0015990 electron transport coupled proton transport; IDA:EcoCyc. # GO_process GO:0019646 aerobic electron transport chain; IDA:EcoCyc. # GO_process GO:0042773 ATP synthesis coupled electron transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0055085 transmembrane transport # Gene3D 1.10.287.90 -; 1. # Gene3D 2.60.40.420 -; 1. # IntAct P0ABJ1 23 # InterPro IPR002429 Cyt_c_oxidase_su2_C # InterPro IPR006333 Cyt_o_ubiquinol_oxidase_su2 # InterPro IPR008972 Cupredoxin # InterPro IPR010514 COX_ARM # InterPro IPR011759 Cyt_c_oxidase_su2_TM_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00190 Oxidative phosphorylation # Organism CYOA_ECOLI Escherichia coli (strain K12) # PATRIC 32116015 VBIEscCol129921_0449 # PDB 1CYW X-ray; 2.50 A; A=111-315 # PDB 1CYX X-ray; 2.30 A; A=111-315 # PDB 1FFT X-ray; 3.50 A; B/G=1-315 # PIR A42226 A42226 # PIRSF PIRSF000292 Ubi_od_II # PROSITE PS50857 COX2_CUA # PROSITE PS50999 COX2_TM # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF00116 COX2 # Pfam PF06481 COX_ARM # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CYOA_ECOLI Cytochrome bo(3) ubiquinol oxidase subunit 2 # RefSeq NP_414966 NC_000913.3 # RefSeq WP_001239436 NZ_LN832404.1 # SIMILARITY Belongs to the cytochrome c oxidase subunit 2 family. {ECO 0000305}. # SUBCELLULAR LOCATION CYOA_ECOLI Cell inner membrane {ECO 0000269|PubMed 16079137, ECO 0000269|PubMed 6365921}; Multi- pass membrane protein {ECO 0000269|PubMed 16079137, ECO 0000269|PubMed 6365921}. # SUBUNIT CYOA_ECOLI Heterooctamer of two A chains, two B chains, two C chains and two D chains. {ECO 0000269|PubMed 11017202, ECO 0000269|PubMed 16079137, ECO 0000269|PubMed 6308657}. # SUPFAM SSF49503 SSF49503 # SUPFAM SSF81464 SSF81464 # TCDB 3.D.4.5 the proton-translocating cytochrome oxidase (cox) superfamily # TIGRFAMs TIGR01433 CyoA # eggNOG COG1622 LUCA # eggNOG ENOG4105E2S Bacteria BLAST swissprot:CYOA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CYOA_ECOLI BioCyc ECOL316407:JW0422-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0422-MONOMER BioCyc EcoCyc:CYOA-MONOMER http://biocyc.org/getid?id=EcoCyc:CYOA-MONOMER BioCyc MetaCyc:CYOA-MONOMER http://biocyc.org/getid?id=MetaCyc:CYOA-MONOMER COG COG1622 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1622 DIP DIP-47942N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47942N DOI 10.1016/0005-2728(90)90231-R http://dx.doi.org/10.1016/0005-2728(90)90231-R DOI 10.1021/bi00145a008 http://dx.doi.org/10.1021/bi00145a008 DOI 10.1038/82824 http://dx.doi.org/10.1038/82824 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.80.16.4889 http://dx.doi.org/10.1073/pnas.80.16.4889 DOI 10.1073/pnas.92.26.11955 http://dx.doi.org/10.1073/pnas.92.26.11955 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1111/j.1365-2958.1993.tb01731.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb01731.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AEM.01507-12 http://dx.doi.org/10.1128/AEM.01507-12 DOI 10.1128/JB.00562-09 http://dx.doi.org/10.1128/JB.00562-09 DisProt DP00089 http://www.disprot.org/protein.php?id=DP00089 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J05492 http://www.ebi.ac.uk/ena/data/view/J05492 EMBL M55258 http://www.ebi.ac.uk/ena/data/view/M55258 EMBL S67816 http://www.ebi.ac.uk/ena/data/view/S67816 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EchoBASE EB0175 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0175 EcoGene EG10178 http://www.ecogene.org/geneInfo.php?eg_id=EG10178 EnsemblBacteria AAC73535 http://www.ensemblgenomes.org/id/AAC73535 EnsemblBacteria AAC73535 http://www.ensemblgenomes.org/id/AAC73535 EnsemblBacteria BAE76212 http://www.ensemblgenomes.org/id/BAE76212 EnsemblBacteria BAE76212 http://www.ensemblgenomes.org/id/BAE76212 EnsemblBacteria BAE76212 http://www.ensemblgenomes.org/id/BAE76212 EnsemblBacteria b0432 http://www.ensemblgenomes.org/id/b0432 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0009319 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009319 GO_component GO:0070469 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070469 GO_component GO:0071575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071575 GO_function GO:0004129 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004129 GO_function GO:0005507 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005507 GO_function GO:0008827 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008827 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0009486 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009486 GO_function GO:0015078 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015078 GO_function GO:0015453 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015453 GO_function GO:0048039 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048039 GO_process GO:0009060 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009060 GO_process GO:0015990 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015990 GO_process GO:0019646 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019646 GO_process GO:0042773 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042773 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 1.10.287.90 http://www.cathdb.info/version/latest/superfamily/1.10.287.90 Gene3D 2.60.40.420 http://www.cathdb.info/version/latest/superfamily/2.60.40.420 GeneID 945080 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945080 HOGENOM HOG000084157 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000084157&db=HOGENOM6 InParanoid P0ABJ1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABJ1 IntAct P0ABJ1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABJ1* InterPro IPR002429 http://www.ebi.ac.uk/interpro/entry/IPR002429 InterPro IPR006333 http://www.ebi.ac.uk/interpro/entry/IPR006333 InterPro IPR008972 http://www.ebi.ac.uk/interpro/entry/IPR008972 InterPro IPR010514 http://www.ebi.ac.uk/interpro/entry/IPR010514 InterPro IPR011759 http://www.ebi.ac.uk/interpro/entry/IPR011759 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0422 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0422 KEGG_Gene eco:b0432 http://www.genome.jp/dbget-bin/www_bget?eco:b0432 KEGG_Orthology KO:K02297 http://www.genome.jp/dbget-bin/www_bget?KO:K02297 KEGG_Pathway ko00190 http://www.genome.jp/kegg-bin/show_pathway?ko00190 OMA TAMNSFF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TAMNSFF PDB 1CYW http://www.ebi.ac.uk/pdbe-srv/view/entry/1CYW PDB 1CYX http://www.ebi.ac.uk/pdbe-srv/view/entry/1CYX PDB 1FFT http://www.ebi.ac.uk/pdbe-srv/view/entry/1FFT PDBsum 1CYW http://www.ebi.ac.uk/pdbsum/1CYW PDBsum 1CYX http://www.ebi.ac.uk/pdbsum/1CYX PDBsum 1FFT http://www.ebi.ac.uk/pdbsum/1FFT PROSITE PS50857 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50857 PROSITE PS50999 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50999 PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:CYOA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CYOA_ECOLI PSORT-B swissprot:CYOA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CYOA_ECOLI PSORT2 swissprot:CYOA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CYOA_ECOLI Pfam PF00116 http://pfam.xfam.org/family/PF00116 Pfam PF06481 http://pfam.xfam.org/family/PF06481 Phobius swissprot:CYOA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CYOA_ECOLI PhylomeDB P0ABJ1 http://phylomedb.org/?seqid=P0ABJ1 ProteinModelPortal P0ABJ1 http://www.proteinmodelportal.org/query/uniprot/P0ABJ1 PubMed 11017202 http://www.ncbi.nlm.nih.gov/pubmed/11017202 PubMed 1322173 http://www.ncbi.nlm.nih.gov/pubmed/1322173 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19542282 http://www.ncbi.nlm.nih.gov/pubmed/19542282 PubMed 2162835 http://www.ncbi.nlm.nih.gov/pubmed/2162835 PubMed 2162837 http://www.ncbi.nlm.nih.gov/pubmed/2162837 PubMed 2165491 http://www.ncbi.nlm.nih.gov/pubmed/2165491 PubMed 2168206 http://www.ncbi.nlm.nih.gov/pubmed/2168206 PubMed 22843529 http://www.ncbi.nlm.nih.gov/pubmed/22843529 PubMed 6308657 http://www.ncbi.nlm.nih.gov/pubmed/6308657 PubMed 6365921 http://www.ncbi.nlm.nih.gov/pubmed/6365921 PubMed 8231804 http://www.ncbi.nlm.nih.gov/pubmed/8231804 PubMed 8618822 http://www.ncbi.nlm.nih.gov/pubmed/8618822 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414966 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414966 RefSeq WP_001239436 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001239436 SMR P0ABJ1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABJ1 STRING 511145.b0432 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0432&targetmode=cogs STRING COG1622 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1622&targetmode=cogs SUPFAM SSF49503 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49503 SUPFAM SSF81464 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81464 TCDB 3.D.4.5 http://www.tcdb.org/search/result.php?tc=3.D.4.5 TIGRFAMs TIGR01433 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01433 UniProtKB CYOA_ECOLI http://www.uniprot.org/uniprot/CYOA_ECOLI UniProtKB-AC P0ABJ1 http://www.uniprot.org/uniprot/P0ABJ1 charge swissprot:CYOA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CYOA_ECOLI eggNOG COG1622 http://eggnogapi.embl.de/nog_data/html/tree/COG1622 eggNOG ENOG4105E2S http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E2S epestfind swissprot:CYOA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CYOA_ECOLI garnier swissprot:CYOA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CYOA_ECOLI helixturnhelix swissprot:CYOA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CYOA_ECOLI hmoment swissprot:CYOA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CYOA_ECOLI iep swissprot:CYOA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CYOA_ECOLI inforesidue swissprot:CYOA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CYOA_ECOLI octanol swissprot:CYOA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CYOA_ECOLI pepcoil swissprot:CYOA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CYOA_ECOLI pepdigest swissprot:CYOA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CYOA_ECOLI pepinfo swissprot:CYOA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CYOA_ECOLI pepnet swissprot:CYOA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CYOA_ECOLI pepstats swissprot:CYOA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CYOA_ECOLI pepwheel swissprot:CYOA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CYOA_ECOLI pepwindow swissprot:CYOA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CYOA_ECOLI sigcleave swissprot:CYOA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CYOA_ECOLI ## Database ID URL or Descriptions # BRENDA 1.1.1.95 2026 # BioGrid 4261173 13 # CATALYTIC ACTIVITY SERA_ECOLI 2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + NADH. # CATALYTIC ACTIVITY SERA_ECOLI 3-phospho-D-glycerate + NAD(+) = 3- phosphonooxypyruvate + NADH. # ENZYME REGULATION SERA_ECOLI In bacteria displays feedback inhibition by L- serine. # EcoGene EG10944 serA # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004617 phosphoglycerate dehydrogenase activity; IDA:EcoCyc. # GO_function GO:0016597 amino acid binding; IEA:InterPro. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0047545 2-hydroxyglutarate dehydrogenase activity; IDA:EcoCyc. # GO_function GO:0051287 NAD binding; IEA:InterPro. # GO_function GO:0070905 serine binding; IDA:EcoCyc. # GO_process GO:0006564 L-serine biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.720 -; 2. # IntAct P0A9T0 3 # InterPro IPR002912 ACT_dom # InterPro IPR006139 D-isomer_2_OHA_DH_cat_dom # InterPro IPR006140 D-isomer_DH_NAD-bd # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR029015 PGDH_2 # InterPro IPR029752 D-isomer_DH_CS1 # InterPro IPR029753 D-isomer_DH_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00260 Glycine, serine and threonine metabolism # KEGG_Pathway ko00680 Methane metabolism # Organism SERA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10996:SF18 PTHR10996:SF18 # PATHWAY Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate step 1/3. # PATRIC 32121238 VBIEscCol129921_3007 # PDB 1PSD X-ray; 2.75 A; A/B=2-410 # PDB 1SC6 X-ray; 2.09 A; A/B/C/D=7-410 # PDB 1YBA X-ray; 2.24 A; A/B/C/D=1-410 # PDB 2P9C X-ray; 2.46 A; A/B=1-410 # PDB 2P9E X-ray; 2.60 A; A/B/C/D=1-410 # PDB 2P9G X-ray; 2.80 A; A/B=1-410 # PDB 2PA3 X-ray; 2.74 A; A=1-410 # PIR A25200 DEECPG # PROSITE PS00065 D_2_HYDROXYACID_DH_1 # PROSITE PS00670 D_2_HYDROXYACID_DH_2 # PROSITE PS00671 D_2_HYDROXYACID_DH_3 # PROSITE PS51671 ACT # Pfam PF00389 2-Hacid_dh # Pfam PF01842 ACT # Pfam PF02826 2-Hacid_dh_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SERA_ECOLI D-3-phosphoglycerate dehydrogenase # RefSeq NP_417388 NC_000913.3 # RefSeq WP_001151604 NZ_LN832404.1 # SIMILARITY Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. {ECO 0000305}. # SIMILARITY Contains 1 ACT domain. {ECO:0000255|PROSITE- ProRule PRU01007}. # SUBUNIT SERA_ECOLI Homotetramer. # SUPFAM SSF51735 SSF51735 # UniPathway UPA00135 UER00196 # eggNOG COG0111 LUCA # eggNOG ENOG4108JQ1 Bacteria BLAST swissprot:SERA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SERA_ECOLI BioCyc ECOL316407:JW2880-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2880-MONOMER BioCyc EcoCyc:PGLYCDEHYDROG-MONOMER http://biocyc.org/getid?id=EcoCyc:PGLYCDEHYDROG-MONOMER BioCyc MetaCyc:PGLYCDEHYDROG-MONOMER http://biocyc.org/getid?id=MetaCyc:PGLYCDEHYDROG-MONOMER COG COG0111 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0111 DIP DIP-10851N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10851N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb0195-69 http://dx.doi.org/10.1038/nsb0195-69 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.95 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.95 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L29397 http://www.ebi.ac.uk/ena/data/view/L29397 EMBL M64630 http://www.ebi.ac.uk/ena/data/view/M64630 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EMBL X66836 http://www.ebi.ac.uk/ena/data/view/X66836 ENZYME 1.1.1.95 http://enzyme.expasy.org/EC/1.1.1.95 EchoBASE EB0937 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0937 EcoGene EG10944 http://www.ecogene.org/geneInfo.php?eg_id=EG10944 EnsemblBacteria AAC75950 http://www.ensemblgenomes.org/id/AAC75950 EnsemblBacteria AAC75950 http://www.ensemblgenomes.org/id/AAC75950 EnsemblBacteria BAE76977 http://www.ensemblgenomes.org/id/BAE76977 EnsemblBacteria BAE76977 http://www.ensemblgenomes.org/id/BAE76977 EnsemblBacteria BAE76977 http://www.ensemblgenomes.org/id/BAE76977 EnsemblBacteria b2913 http://www.ensemblgenomes.org/id/b2913 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004617 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004617 GO_function GO:0016597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016597 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0047545 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047545 GO_function GO:0051287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051287 GO_function GO:0070905 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070905 GO_process GO:0006564 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006564 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 945258 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945258 HOGENOM HOG000136696 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000136696&db=HOGENOM6 InParanoid P0A9T0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9T0 IntAct P0A9T0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9T0* IntEnz 1.1.1.95 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.95 InterPro IPR002912 http://www.ebi.ac.uk/interpro/entry/IPR002912 InterPro IPR006139 http://www.ebi.ac.uk/interpro/entry/IPR006139 InterPro IPR006140 http://www.ebi.ac.uk/interpro/entry/IPR006140 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR029015 http://www.ebi.ac.uk/interpro/entry/IPR029015 InterPro IPR029752 http://www.ebi.ac.uk/interpro/entry/IPR029752 InterPro IPR029753 http://www.ebi.ac.uk/interpro/entry/IPR029753 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2880 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2880 KEGG_Gene eco:b2913 http://www.genome.jp/dbget-bin/www_bget?eco:b2913 KEGG_Orthology KO:K00058 http://www.genome.jp/dbget-bin/www_bget?KO:K00058 KEGG_Pathway ko00260 http://www.genome.jp/kegg-bin/show_pathway?ko00260 KEGG_Pathway ko00680 http://www.genome.jp/kegg-bin/show_pathway?ko00680 KEGG_Reaction rn:R01513 http://www.genome.jp/dbget-bin/www_bget?rn:R01513 OMA KFVKYSD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KFVKYSD PANTHER PTHR10996:SF18 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10996:SF18 PDB 1PSD http://www.ebi.ac.uk/pdbe-srv/view/entry/1PSD PDB 1SC6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1SC6 PDB 1YBA http://www.ebi.ac.uk/pdbe-srv/view/entry/1YBA PDB 2P9C http://www.ebi.ac.uk/pdbe-srv/view/entry/2P9C PDB 2P9E http://www.ebi.ac.uk/pdbe-srv/view/entry/2P9E PDB 2P9G http://www.ebi.ac.uk/pdbe-srv/view/entry/2P9G PDB 2PA3 http://www.ebi.ac.uk/pdbe-srv/view/entry/2PA3 PDBsum 1PSD http://www.ebi.ac.uk/pdbsum/1PSD PDBsum 1SC6 http://www.ebi.ac.uk/pdbsum/1SC6 PDBsum 1YBA http://www.ebi.ac.uk/pdbsum/1YBA PDBsum 2P9C http://www.ebi.ac.uk/pdbsum/2P9C PDBsum 2P9E http://www.ebi.ac.uk/pdbsum/2P9E PDBsum 2P9G http://www.ebi.ac.uk/pdbsum/2P9G PDBsum 2PA3 http://www.ebi.ac.uk/pdbsum/2PA3 PROSITE PS00065 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00065 PROSITE PS00670 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00670 PROSITE PS00671 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00671 PROSITE PS51671 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51671 PSORT swissprot:SERA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SERA_ECOLI PSORT-B swissprot:SERA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SERA_ECOLI PSORT2 swissprot:SERA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SERA_ECOLI Pfam PF00389 http://pfam.xfam.org/family/PF00389 Pfam PF01842 http://pfam.xfam.org/family/PF01842 Pfam PF02826 http://pfam.xfam.org/family/PF02826 Phobius swissprot:SERA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SERA_ECOLI PhylomeDB P0A9T0 http://phylomedb.org/?seqid=P0A9T0 ProteinModelPortal P0A9T0 http://www.proteinmodelportal.org/query/uniprot/P0A9T0 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1917830 http://www.ncbi.nlm.nih.gov/pubmed/1917830 PubMed 3017965 http://www.ncbi.nlm.nih.gov/pubmed/3017965 PubMed 7719856 http://www.ncbi.nlm.nih.gov/pubmed/7719856 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_417388 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417388 RefSeq WP_001151604 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001151604 SMR P0A9T0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9T0 STRING 511145.b2913 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2913&targetmode=cogs STRING COG0111 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0111&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB SERA_ECOLI http://www.uniprot.org/uniprot/SERA_ECOLI UniProtKB-AC P0A9T0 http://www.uniprot.org/uniprot/P0A9T0 charge swissprot:SERA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SERA_ECOLI eggNOG COG0111 http://eggnogapi.embl.de/nog_data/html/tree/COG0111 eggNOG ENOG4108JQ1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108JQ1 epestfind swissprot:SERA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SERA_ECOLI garnier swissprot:SERA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SERA_ECOLI helixturnhelix swissprot:SERA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SERA_ECOLI hmoment swissprot:SERA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SERA_ECOLI iep swissprot:SERA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SERA_ECOLI inforesidue swissprot:SERA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SERA_ECOLI octanol swissprot:SERA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SERA_ECOLI pepcoil swissprot:SERA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SERA_ECOLI pepdigest swissprot:SERA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SERA_ECOLI pepinfo swissprot:SERA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SERA_ECOLI pepnet swissprot:SERA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SERA_ECOLI pepstats swissprot:SERA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SERA_ECOLI pepwheel swissprot:SERA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SERA_ECOLI pepwindow swissprot:SERA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SERA_ECOLI sigcleave swissprot:SERA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SERA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261415 28 # EcoGene EG13011 yqhA # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # HAMAP MF_00143 UPF0114 # InterPro IPR005134 UPF0114 # InterPro IPR020761 UPF0114_bac # InterPro IPR020765 UPF0114_gbac # Organism YQHA_ECOLI Escherichia coli (strain K12) # PATRIC 32121422 VBIEscCol129921_3098 # PIR H65086 H65086 # Pfam PF03350 UPF0114 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQHA_ECOLI UPF0114 protein YqhA # RefSeq NP_417475 NC_000913.3 # RefSeq WP_000439331 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0114 family. {ECO 0000305}. # SUBCELLULAR LOCATION YQHA_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # TIGRFAMs TIGR00645 HI0507 # eggNOG COG2862 LUCA # eggNOG ENOG4108TEB Bacteria BLAST swissprot:YQHA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQHA_ECOLI BioCyc ECOL316407:JW2971-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2971-MONOMER BioCyc EcoCyc:G7559-MONOMER http://biocyc.org/getid?id=EcoCyc:G7559-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2832 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2832 EcoGene EG13011 http://www.ecogene.org/geneInfo.php?eg_id=EG13011 EnsemblBacteria AAC76038 http://www.ensemblgenomes.org/id/AAC76038 EnsemblBacteria AAC76038 http://www.ensemblgenomes.org/id/AAC76038 EnsemblBacteria BAE77061 http://www.ensemblgenomes.org/id/BAE77061 EnsemblBacteria BAE77061 http://www.ensemblgenomes.org/id/BAE77061 EnsemblBacteria BAE77061 http://www.ensemblgenomes.org/id/BAE77061 EnsemblBacteria b3002 http://www.ensemblgenomes.org/id/b3002 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 947479 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947479 HAMAP MF_00143 http://hamap.expasy.org/unirule/MF_00143 HOGENOM HOG000262358 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000262358&db=HOGENOM6 InParanoid P67244 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P67244 InterPro IPR005134 http://www.ebi.ac.uk/interpro/entry/IPR005134 InterPro IPR020761 http://www.ebi.ac.uk/interpro/entry/IPR020761 InterPro IPR020765 http://www.ebi.ac.uk/interpro/entry/IPR020765 KEGG_Gene ecj:JW2971 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2971 KEGG_Gene eco:b3002 http://www.genome.jp/dbget-bin/www_bget?eco:b3002 OMA FIENAMY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FIENAMY PSORT swissprot:YQHA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQHA_ECOLI PSORT-B swissprot:YQHA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQHA_ECOLI PSORT2 swissprot:YQHA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQHA_ECOLI Pfam PF03350 http://pfam.xfam.org/family/PF03350 Phobius swissprot:YQHA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQHA_ECOLI PhylomeDB P67244 http://phylomedb.org/?seqid=P67244 ProteinModelPortal P67244 http://www.proteinmodelportal.org/query/uniprot/P67244 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417475 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417475 RefSeq WP_000439331 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000439331 STRING 511145.b3002 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3002&targetmode=cogs TIGRFAMs TIGR00645 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00645 UniProtKB YQHA_ECOLI http://www.uniprot.org/uniprot/YQHA_ECOLI UniProtKB-AC P67244 http://www.uniprot.org/uniprot/P67244 charge swissprot:YQHA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQHA_ECOLI eggNOG COG2862 http://eggnogapi.embl.de/nog_data/html/tree/COG2862 eggNOG ENOG4108TEB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108TEB epestfind swissprot:YQHA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQHA_ECOLI garnier swissprot:YQHA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQHA_ECOLI helixturnhelix swissprot:YQHA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQHA_ECOLI hmoment swissprot:YQHA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQHA_ECOLI iep swissprot:YQHA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQHA_ECOLI inforesidue swissprot:YQHA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQHA_ECOLI octanol swissprot:YQHA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQHA_ECOLI pepcoil swissprot:YQHA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQHA_ECOLI pepdigest swissprot:YQHA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQHA_ECOLI pepinfo swissprot:YQHA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQHA_ECOLI pepnet swissprot:YQHA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQHA_ECOLI pepstats swissprot:YQHA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQHA_ECOLI pepwheel swissprot:YQHA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQHA_ECOLI pepwindow swissprot:YQHA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQHA_ECOLI sigcleave swissprot:YQHA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQHA_ECOLI ## Database ID URL or Descriptions # AltName AHPF_ECOLI Alkyl hydroperoxide reductase F52A protein # BioGrid 4260706 6 # COFACTOR AHPF_ECOLI Name=FAD; Xref=ChEBI CHEBI 57692; Evidence={ECO 0000250}; Note=Binds 1 FAD per subunit. {ECO 0000250}; # DrugBank DB03147 Flavin adenine dinucleotide # EcoGene EG11385 ahpF # FUNCTION AHPF_ECOLI Serves to protect the cell against DNA damage by alkyl hydroperoxides. It can use either NADH or NADPH as electron donor for direct reduction of redox dyes or of alkyl hydroperoxides when combined with the AhpC protein. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0009321 alkyl hydroperoxide reductase complex; IDA:EcoCyc. # GO_function GO:0008785 alkyl hydroperoxide reductase activity; IGI:EcoliWiki. # GO_function GO:0009055 electron carrier activity; IEA:InterPro. # GO_function GO:0015035 protein disulfide oxidoreductase activity; IEA:InterPro. # GO_function GO:0050660 flavin adenine dinucleotide binding; ISM:EcoliWiki. # GO_function GO:0051287 NAD binding; IEA:InterPro. # GO_function GO:0070402 NADPH binding; ISM:EcoliWiki. # GO_function GO:0071949 FAD binding; IDA:EcoCyc. # GO_process GO:0000302 response to reactive oxygen species; IEA:InterPro. # GO_process GO:0045454 cell redox homeostasis; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0042592 homeostatic process # Gene3D 3.40.30.10 -; 2. # Gene3D 3.50.50.60 -; 2. # IntAct P35340 21 # InterPro IPR000103 Pyridine_nuc-diS_OxRdtase_2 # InterPro IPR002109 Glutaredoxin # InterPro IPR008255 Pyr_nucl-diS_OxRdtase_2_AS # InterPro IPR012081 Alkyl_hydroperoxide_Rdtase_suF # InterPro IPR012336 Thioredoxin-like_fold # InterPro IPR023753 FAD/NAD-binding_dom # KEGG_Brite ko01000 Enzymes # MISCELLANEOUS AHPF_ECOLI The active site is a redox-active disulfide bond. # Organism AHPF_ECOLI Escherichia coli (strain K12) # PATRIC 32116392 VBIEscCol129921_0636 # PDB 1FL2 X-ray; 1.90 A; A=212-521 # PDB 4O5Q X-ray; 2.00 A; A=1-521 # PDB 4O5U X-ray; 2.65 A; A=1-521 # PDB 4XVG X-ray; 2.20 A; A=1-521 # PDB 4YKF X-ray; 2.50 A; A=1-521 # PDB 4YKG X-ray; 2.40 A; A=1-521 # PIRSF PIRSF000238 AhpF # PRINTS PR00469 PNDRDTASEII # PROSITE PS00573 PYRIDINE_REDOX_2 # PROSITE PS51354 GLUTAREDOXIN_2 # Pfam PF07992 Pyr_redox_2 # Pfam PF13192 Thioredoxin_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AHPF_ECOLI Alkyl hydroperoxide reductase subunit F # RefSeq NP_415139 NC_000913.3 # RefSeq WP_000887629 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40807.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family. {ECO 0000305}. # SUBUNIT AHPF_ECOLI Homodimer. # SUPFAM SSF51905 SSF51905 # SUPFAM SSF52833 SSF52833; 2 # TIGRFAMs TIGR03140 AhpF # eggNOG COG3634 LUCA # eggNOG ENOG4108JU3 Bacteria BLAST swissprot:AHPF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AHPF_ECOLI BioCyc ECOL316407:JW0599-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0599-MONOMER BioCyc EcoCyc:EG11385-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11385-MONOMER BioCyc MetaCyc:EG11385-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11385-MONOMER COG COG3634 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3634 DIP DIP-9077N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9077N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB03147 http://www.drugbank.ca/drugs/DB03147 EC_number EC:1.8.1.- http://www.genome.jp/dbget-bin/www_bget?EC:1.8.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D13187 http://www.ebi.ac.uk/ena/data/view/D13187 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 ENZYME 1.8.1.- http://enzyme.expasy.org/EC/1.8.1.- EchoBASE EB1358 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1358 EcoGene EG11385 http://www.ecogene.org/geneInfo.php?eg_id=EG11385 EnsemblBacteria AAC73707 http://www.ensemblgenomes.org/id/AAC73707 EnsemblBacteria AAC73707 http://www.ensemblgenomes.org/id/AAC73707 EnsemblBacteria BAA35236 http://www.ensemblgenomes.org/id/BAA35236 EnsemblBacteria BAA35236 http://www.ensemblgenomes.org/id/BAA35236 EnsemblBacteria BAA35236 http://www.ensemblgenomes.org/id/BAA35236 EnsemblBacteria b0606 http://www.ensemblgenomes.org/id/b0606 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0009321 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009321 GO_function GO:0008785 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008785 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0015035 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015035 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_function GO:0051287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051287 GO_function GO:0070402 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070402 GO_function GO:0071949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071949 GO_process GO:0000302 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000302 GO_process GO:0045454 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045454 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 Gene3D 3.40.30.10 http://www.cathdb.info/version/latest/superfamily/3.40.30.10 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 GeneID 947540 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947540 HOGENOM HOG000169462 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000169462&db=HOGENOM6 InParanoid P35340 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P35340 IntAct P35340 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P35340* IntEnz 1.8.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.8.1 InterPro IPR000103 http://www.ebi.ac.uk/interpro/entry/IPR000103 InterPro IPR002109 http://www.ebi.ac.uk/interpro/entry/IPR002109 InterPro IPR008255 http://www.ebi.ac.uk/interpro/entry/IPR008255 InterPro IPR012081 http://www.ebi.ac.uk/interpro/entry/IPR012081 InterPro IPR012336 http://www.ebi.ac.uk/interpro/entry/IPR012336 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0599 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0599 KEGG_Gene eco:b0606 http://www.genome.jp/dbget-bin/www_bget?eco:b0606 KEGG_Orthology KO:K03387 http://www.genome.jp/dbget-bin/www_bget?KO:K03387 OMA AVRKPSF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AVRKPSF PDB 1FL2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1FL2 PDB 4O5Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4O5Q PDB 4O5U http://www.ebi.ac.uk/pdbe-srv/view/entry/4O5U PDB 4XVG http://www.ebi.ac.uk/pdbe-srv/view/entry/4XVG PDB 4YKF http://www.ebi.ac.uk/pdbe-srv/view/entry/4YKF PDB 4YKG http://www.ebi.ac.uk/pdbe-srv/view/entry/4YKG PDBsum 1FL2 http://www.ebi.ac.uk/pdbsum/1FL2 PDBsum 4O5Q http://www.ebi.ac.uk/pdbsum/4O5Q PDBsum 4O5U http://www.ebi.ac.uk/pdbsum/4O5U PDBsum 4XVG http://www.ebi.ac.uk/pdbsum/4XVG PDBsum 4YKF http://www.ebi.ac.uk/pdbsum/4YKF PDBsum 4YKG http://www.ebi.ac.uk/pdbsum/4YKG PRINTS PR00469 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00469 PROSITE PS00573 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00573 PROSITE PS51354 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51354 PSORT swissprot:AHPF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AHPF_ECOLI PSORT-B swissprot:AHPF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AHPF_ECOLI PSORT2 swissprot:AHPF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AHPF_ECOLI Pfam PF07992 http://pfam.xfam.org/family/PF07992 Pfam PF13192 http://pfam.xfam.org/family/PF13192 Phobius swissprot:AHPF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AHPF_ECOLI PhylomeDB P35340 http://phylomedb.org/?seqid=P35340 ProteinModelPortal P35340 http://www.proteinmodelportal.org/query/uniprot/P35340 PubMed 1592833 http://www.ncbi.nlm.nih.gov/pubmed/1592833 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415139 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415139 RefSeq WP_000887629 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000887629 SMR P35340 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P35340 STRING 511145.b0606 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0606&targetmode=cogs STRING COG3634 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3634&targetmode=cogs SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 SUPFAM SSF52833 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52833 SWISS-2DPAGE P35340 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P35340 TIGRFAMs TIGR03140 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03140 UniProtKB AHPF_ECOLI http://www.uniprot.org/uniprot/AHPF_ECOLI UniProtKB-AC P35340 http://www.uniprot.org/uniprot/P35340 charge swissprot:AHPF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AHPF_ECOLI eggNOG COG3634 http://eggnogapi.embl.de/nog_data/html/tree/COG3634 eggNOG ENOG4108JU3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108JU3 epestfind swissprot:AHPF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AHPF_ECOLI garnier swissprot:AHPF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AHPF_ECOLI helixturnhelix swissprot:AHPF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AHPF_ECOLI hmoment swissprot:AHPF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AHPF_ECOLI iep swissprot:AHPF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AHPF_ECOLI inforesidue swissprot:AHPF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AHPF_ECOLI octanol swissprot:AHPF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AHPF_ECOLI pepcoil swissprot:AHPF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AHPF_ECOLI pepdigest swissprot:AHPF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AHPF_ECOLI pepinfo swissprot:AHPF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AHPF_ECOLI pepnet swissprot:AHPF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AHPF_ECOLI pepstats swissprot:AHPF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AHPF_ECOLI pepwheel swissprot:AHPF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AHPF_ECOLI pepwindow swissprot:AHPF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AHPF_ECOLI sigcleave swissprot:AHPF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AHPF_ECOLI ## Database ID URL or Descriptions # BioGrid 4262711 9 # DISRUPTION PHENOTYPE Cells lacking this gene show a more rapid utilization of L-ascorbate and are able to grow on L-ascorbate under microaerophilic conditions. {ECO:0000269|PubMed 12644495}. # EcoGene EG12491 ulaR # FUNCTION ULAR_ECOLI Represses ulaG and the ulaABCDEF operon. Two ulaR binding sites have been identified in each promoter. Full activity requires simultaneous interaction of UlaR with both divergent promoters and seems to be dependent on repressor-mediated DNA loop formation, which is helped by the action of integration host factor. {ECO 0000269|PubMed 12374842, ECO 0000269|PubMed 12644495, ECO 0000269|PubMed 14996803}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_function GO:0031418 L-ascorbic acid binding; IMP:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEP:EcoCyc. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # HAMAP MF_01563 HTH_type_UlaR # INTERACTION ULAR_ECOLI P0A6F5 groL; NbExp=3; IntAct=EBI-560926, EBI-543750; # IntAct P0A9W0 40 # InterPro IPR001034 DeoR_HTH # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR014036 DeoR_C # InterPro IPR018356 Tscrpt_reg_HTH_DeoR_CS # InterPro IPR023711 Tscrpt_reg_HTH_UlaR # KEGG_Brite ko03000 Transcription factors # Organism ULAR_ECOLI Escherichia coli (strain K12) # PATRIC 32123957 VBIEscCol129921_4323 # PIR S56416 S56416 # PRINTS PR00037 HTHLACR # PROSITE PS00894 HTH_DEOR_1 # PROSITE PS51000 HTH_DEOR_2 # Pfam PF00455 DeoRC # Pfam PF08220 HTH_DeoR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ULAR_ECOLI HTH-type transcriptional regulator UlaR # RefSeq NP_418612 NC_000913.3 # RefSeq WP_000133631 NZ_LN832404.1 # SIMILARITY Contains 1 HTH deoR-type DNA-binding domain. {ECO 0000305}. # SMART SM00420 HTH_DEOR # SUBCELLULAR LOCATION ULAR_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF46785 SSF46785 # eggNOG COG1349 LUCA # eggNOG ENOG4105DW5 Bacteria BLAST swissprot:ULAR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ULAR_ECOLI BioCyc ECOL316407:JW4149-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4149-MONOMER BioCyc EcoCyc:G7854-MONOMER http://biocyc.org/getid?id=EcoCyc:G7854-MONOMER COG COG1349 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1349 DIP DIP-47874N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47874N DOI 10.1007/s00239-002-2423-0 http://dx.doi.org/10.1007/s00239-002-2423-0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.21.6065-6068.2002 http://dx.doi.org/10.1128/JB.184.21.6065-6068.2002 DOI 10.1128/JB.185.7.2243-2250.2003 http://dx.doi.org/10.1128/JB.185.7.2243-2250.2003 DOI 10.1128/JB.186.6.1720-1728.2004 http://dx.doi.org/10.1128/JB.186.6.1720-1728.2004 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL AY625132 http://www.ebi.ac.uk/ena/data/view/AY625132 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2384 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2384 EcoGene EG12491 http://www.ecogene.org/geneInfo.php?eg_id=EG12491 EnsemblBacteria AAC77148 http://www.ensemblgenomes.org/id/AAC77148 EnsemblBacteria AAC77148 http://www.ensemblgenomes.org/id/AAC77148 EnsemblBacteria BAE78192 http://www.ensemblgenomes.org/id/BAE78192 EnsemblBacteria BAE78192 http://www.ensemblgenomes.org/id/BAE78192 EnsemblBacteria BAE78192 http://www.ensemblgenomes.org/id/BAE78192 EnsemblBacteria b4191 http://www.ensemblgenomes.org/id/b4191 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0031418 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031418 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 948706 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948706 HAMAP MF_01563 http://hamap.expasy.org/unirule/MF_01563 HOGENOM HOG000224683 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000224683&db=HOGENOM6 IntAct P0A9W0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9W0* InterPro IPR001034 http://www.ebi.ac.uk/interpro/entry/IPR001034 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR014036 http://www.ebi.ac.uk/interpro/entry/IPR014036 InterPro IPR018356 http://www.ebi.ac.uk/interpro/entry/IPR018356 InterPro IPR023711 http://www.ebi.ac.uk/interpro/entry/IPR023711 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW4149 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4149 KEGG_Gene eco:b4191 http://www.genome.jp/dbget-bin/www_bget?eco:b4191 KEGG_Orthology KO:K03477 http://www.genome.jp/dbget-bin/www_bget?KO:K03477 MINT MINT-1221501 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1221501 OMA DQEHESV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DQEHESV PRINTS PR00037 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00037 PROSITE PS00894 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00894 PROSITE PS51000 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51000 PSORT swissprot:ULAR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ULAR_ECOLI PSORT-B swissprot:ULAR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ULAR_ECOLI PSORT2 swissprot:ULAR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ULAR_ECOLI Pfam PF00455 http://pfam.xfam.org/family/PF00455 Pfam PF08220 http://pfam.xfam.org/family/PF08220 Phobius swissprot:ULAR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ULAR_ECOLI PhylomeDB P0A9W0 http://phylomedb.org/?seqid=P0A9W0 ProteinModelPortal P0A9W0 http://www.proteinmodelportal.org/query/uniprot/P0A9W0 PubMed 12374842 http://www.ncbi.nlm.nih.gov/pubmed/12374842 PubMed 12644495 http://www.ncbi.nlm.nih.gov/pubmed/12644495 PubMed 12664169 http://www.ncbi.nlm.nih.gov/pubmed/12664169 PubMed 14996803 http://www.ncbi.nlm.nih.gov/pubmed/14996803 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418612 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418612 RefSeq WP_000133631 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000133631 SMART SM00420 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00420 STRING 511145.b4191 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4191&targetmode=cogs STRING COG1349 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1349&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB ULAR_ECOLI http://www.uniprot.org/uniprot/ULAR_ECOLI UniProtKB-AC P0A9W0 http://www.uniprot.org/uniprot/P0A9W0 charge swissprot:ULAR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ULAR_ECOLI eggNOG COG1349 http://eggnogapi.embl.de/nog_data/html/tree/COG1349 eggNOG ENOG4105DW5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DW5 epestfind swissprot:ULAR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ULAR_ECOLI garnier swissprot:ULAR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ULAR_ECOLI helixturnhelix swissprot:ULAR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ULAR_ECOLI hmoment swissprot:ULAR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ULAR_ECOLI iep swissprot:ULAR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ULAR_ECOLI inforesidue swissprot:ULAR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ULAR_ECOLI octanol swissprot:ULAR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ULAR_ECOLI pepcoil swissprot:ULAR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ULAR_ECOLI pepdigest swissprot:ULAR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ULAR_ECOLI pepinfo swissprot:ULAR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ULAR_ECOLI pepnet swissprot:ULAR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ULAR_ECOLI pepstats swissprot:ULAR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ULAR_ECOLI pepwheel swissprot:ULAR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ULAR_ECOLI pepwindow swissprot:ULAR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ULAR_ECOLI sigcleave swissprot:ULAR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ULAR_ECOLI ## Database ID URL or Descriptions # BioGrid 4259194 13 # EcoGene EG11147 yffB # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # Gene3D 3.40.30.10 -; 1. # IntAct P24178 19 # InterPro IPR006504 Tscrpt_reg_Spx/MgsR # InterPro IPR006660 Arsenate_reductase-like # InterPro IPR012336 Thioredoxin-like_fold # Organism YFFB_ECOLI Escherichia coli (strain K12) # PATRIC 32120325 VBIEscCol129921_2565 # PIR B42959 B42959 # PROSITE PS51353 ARSC # Pfam PF03960 ArsC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFFB_ECOLI Protein YffB # RefSeq NP_416966 NC_000913.3 # RefSeq WP_000258236 NZ_LN832404.1 # SIMILARITY Belongs to the ArsC family. {ECO 0000305}. # SUPFAM SSF52833 SSF52833 # TIGRFAMs TIGR01617 arsC_related # eggNOG COG1393 LUCA # eggNOG ENOG4105KUZ Bacteria BLAST swissprot:YFFB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFFB_ECOLI BioCyc ECOL316407:JW2455-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2455-MONOMER BioCyc EcoCyc:EG11147-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11147-MONOMER DIP DIP-12024N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12024N DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X57403 http://www.ebi.ac.uk/ena/data/view/X57403 EchoBASE EB1137 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1137 EcoGene EG11147 http://www.ecogene.org/geneInfo.php?eg_id=EG11147 EnsemblBacteria AAC75524 http://www.ensemblgenomes.org/id/AAC75524 EnsemblBacteria AAC75524 http://www.ensemblgenomes.org/id/AAC75524 EnsemblBacteria BAA16345 http://www.ensemblgenomes.org/id/BAA16345 EnsemblBacteria BAA16345 http://www.ensemblgenomes.org/id/BAA16345 EnsemblBacteria BAA16345 http://www.ensemblgenomes.org/id/BAA16345 EnsemblBacteria b2471 http://www.ensemblgenomes.org/id/b2471 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 Gene3D 3.40.30.10 http://www.cathdb.info/version/latest/superfamily/3.40.30.10 GeneID 946953 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946953 HOGENOM HOG000059714 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000059714&db=HOGENOM6 InParanoid P24178 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P24178 IntAct P24178 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P24178* InterPro IPR006504 http://www.ebi.ac.uk/interpro/entry/IPR006504 InterPro IPR006660 http://www.ebi.ac.uk/interpro/entry/IPR006660 InterPro IPR012336 http://www.ebi.ac.uk/interpro/entry/IPR012336 KEGG_Gene ecj:JW2455 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2455 KEGG_Gene eco:b2471 http://www.genome.jp/dbget-bin/www_bget?eco:b2471 MINT MINT-1255719 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1255719 OMA FGIKNCD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FGIKNCD PROSITE PS51353 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51353 PSORT swissprot:YFFB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFFB_ECOLI PSORT-B swissprot:YFFB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFFB_ECOLI PSORT2 swissprot:YFFB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFFB_ECOLI Pfam PF03960 http://pfam.xfam.org/family/PF03960 Phobius swissprot:YFFB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFFB_ECOLI PhylomeDB P24178 http://phylomedb.org/?seqid=P24178 ProteinModelPortal P24178 http://www.proteinmodelportal.org/query/uniprot/P24178 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 1644752 http://www.ncbi.nlm.nih.gov/pubmed/1644752 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416966 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416966 RefSeq WP_000258236 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000258236 SMR P24178 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P24178 STRING 511145.b2471 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2471&targetmode=cogs SUPFAM SSF52833 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52833 TIGRFAMs TIGR01617 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01617 UniProtKB YFFB_ECOLI http://www.uniprot.org/uniprot/YFFB_ECOLI UniProtKB-AC P24178 http://www.uniprot.org/uniprot/P24178 charge swissprot:YFFB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFFB_ECOLI eggNOG COG1393 http://eggnogapi.embl.de/nog_data/html/tree/COG1393 eggNOG ENOG4105KUZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KUZ epestfind swissprot:YFFB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFFB_ECOLI garnier swissprot:YFFB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFFB_ECOLI helixturnhelix swissprot:YFFB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFFB_ECOLI hmoment swissprot:YFFB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFFB_ECOLI iep swissprot:YFFB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFFB_ECOLI inforesidue swissprot:YFFB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFFB_ECOLI octanol swissprot:YFFB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFFB_ECOLI pepcoil swissprot:YFFB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFFB_ECOLI pepdigest swissprot:YFFB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFFB_ECOLI pepinfo swissprot:YFFB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFFB_ECOLI pepnet swissprot:YFFB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFFB_ECOLI pepstats swissprot:YFFB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFFB_ECOLI pepwheel swissprot:YFFB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFFB_ECOLI pepwindow swissprot:YFFB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFFB_ECOLI sigcleave swissprot:YFFB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFFB_ECOLI ## Database ID URL or Descriptions # BioGrid 4262095 12 # DISRUPTION PHENOTYPE Cells are sensitive to exposure to ethanol but not heat in stationary phase. {ECO:0000269|PubMed 9829921}. # EcoGene EG12231 uspB # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006950 response to stress; IEA:UniProtKB-HAMAP. # GO_process GO:0045471 response to ethanol; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # HAMAP MF_01088 UspB # INDUCTION USPB_ECOLI By growth arrest in general, by carbon, phosphate, and nitrogen starvation as well as osmotic shock and oxidative stress. # InterPro IPR019598 Universal_stress_protein_B # KEGG_Brite ko02000 Transporters # MISCELLANEOUS USPB_ECOLI Overexpression of uspB causes cell death in stationary phase. # Organism USPB_ECOLI Escherichia coli (strain K12) # PATRIC 32122438 VBIEscCol129921_3596 # PIR S47714 S47714 # Pfam PF10625 UspB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName USPB_ECOLI Universal stress protein B # RefSeq NP_417951 NC_000913.3 # RefSeq WP_000626187 NZ_LN832404.1 # SIMILARITY Belongs to the universal stress protein B family. {ECO 0000305}. # SUBCELLULAR LOCATION USPB_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 9.B.4.1 the universal stress protein-b (uspb) family # eggNOG ENOG4108V6B Bacteria # eggNOG ENOG4111J5S LUCA BLAST swissprot:USPB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:USPB_ECOLI BioCyc ECOL316407:JW3461-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3461-MONOMER BioCyc EcoCyc:EG12231-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12231-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2143 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2143 EcoGene EG12231 http://www.ecogene.org/geneInfo.php?eg_id=EG12231 EnsemblBacteria AAC76519 http://www.ensemblgenomes.org/id/AAC76519 EnsemblBacteria AAC76519 http://www.ensemblgenomes.org/id/AAC76519 EnsemblBacteria BAE77800 http://www.ensemblgenomes.org/id/BAE77800 EnsemblBacteria BAE77800 http://www.ensemblgenomes.org/id/BAE77800 EnsemblBacteria BAE77800 http://www.ensemblgenomes.org/id/BAE77800 EnsemblBacteria b3494 http://www.ensemblgenomes.org/id/b3494 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GO_process GO:0045471 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045471 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 948008 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948008 HAMAP MF_01088 http://hamap.expasy.org/unirule/MF_01088 HOGENOM HOG000218234 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218234&db=HOGENOM6 InterPro IPR019598 http://www.ebi.ac.uk/interpro/entry/IPR019598 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3461 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3461 KEGG_Gene eco:b3494 http://www.genome.jp/dbget-bin/www_bget?eco:b3494 KEGG_Orthology KO:K06144 http://www.genome.jp/dbget-bin/www_bget?KO:K06144 OMA GGFFTAH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GGFFTAH PSORT swissprot:USPB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:USPB_ECOLI PSORT-B swissprot:USPB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:USPB_ECOLI PSORT2 swissprot:USPB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:USPB_ECOLI Pfam PF10625 http://pfam.xfam.org/family/PF10625 Phobius swissprot:USPB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:USPB_ECOLI ProteinModelPortal P0A8S5 http://www.proteinmodelportal.org/query/uniprot/P0A8S5 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9829921 http://www.ncbi.nlm.nih.gov/pubmed/9829921 RefSeq NP_417951 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417951 RefSeq WP_000626187 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000626187 SMR P0A8S5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8S5 STRING 511145.b3494 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3494&targetmode=cogs TCDB 9.B.4.1 http://www.tcdb.org/search/result.php?tc=9.B.4.1 UniProtKB USPB_ECOLI http://www.uniprot.org/uniprot/USPB_ECOLI UniProtKB-AC P0A8S5 http://www.uniprot.org/uniprot/P0A8S5 charge swissprot:USPB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:USPB_ECOLI eggNOG ENOG4108V6B http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108V6B eggNOG ENOG4111J5S http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111J5S epestfind swissprot:USPB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:USPB_ECOLI garnier swissprot:USPB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:USPB_ECOLI helixturnhelix swissprot:USPB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:USPB_ECOLI hmoment swissprot:USPB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:USPB_ECOLI iep swissprot:USPB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:USPB_ECOLI inforesidue swissprot:USPB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:USPB_ECOLI octanol swissprot:USPB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:USPB_ECOLI pepcoil swissprot:USPB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:USPB_ECOLI pepdigest swissprot:USPB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:USPB_ECOLI pepinfo swissprot:USPB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:USPB_ECOLI pepnet swissprot:USPB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:USPB_ECOLI pepstats swissprot:USPB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:USPB_ECOLI pepwheel swissprot:USPB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:USPB_ECOLI pepwindow swissprot:USPB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:USPB_ECOLI sigcleave swissprot:USPB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:USPB_ECOLI ## Database ID URL or Descriptions # EcoGene EG40008 insH1 # FUNCTION INSH1_ECOLI Involved in the transposition of the insertion sequence IS5. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # InterPro IPR002559 Transposase_11 # InterPro IPR008490 Transposase_InsH_N # Organism INSH1_ECOLI Escherichia coli (strain K12) # PIR A64964 A64964 # PIR A91483 IEEC5D # Pfam PF01609 DDE_Tnp_1 # Pfam PF05598 DUF772 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSH1_ECOLI Transposase InsH for insertion sequence element IS5A # RefSeq NP_414793 NC_000913.3 # RefSeq NP_415084 NC_000913.3 # RefSeq NP_415189 NC_000913.3 # RefSeq NP_415847 NC_000913.3 # RefSeq NP_416535 NC_000913.3 # RefSeq NP_416696 NC_000913.3 # RefSeq NP_417456 NC_000913.3 # RefSeq NP_417685 NC_000913.3 # RefSeq NP_417962 NC_000913.3 # SIMILARITY Belongs to the transposase 11 family. {ECO 0000305}. # eggNOG COG3039 LUCA # eggNOG ENOG4105F2I Bacteria BLAST swissprot:INSH1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSH1_ECOLI BioCyc EcoCyc:G7769-MONOMER http://biocyc.org/getid?id=EcoCyc:G7769-MONOMER DOI 10.1016/0378-1119(81)90111-6 http://dx.doi.org/10.1016/0378-1119(81)90111-6 DOI 10.1016/0378-1119(81)90112-8 http://dx.doi.org/10.1016/0378-1119(81)90112-8 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01734 http://www.ebi.ac.uk/ena/data/view/J01734 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EchoBASE EB4704 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4704 EcoGene EG40008 http://www.ecogene.org/geneInfo.php?eg_id=EG40008 EnsemblBacteria AAC73362 http://www.ensemblgenomes.org/id/AAC73362 EnsemblBacteria AAC73362 http://www.ensemblgenomes.org/id/AAC73362 EnsemblBacteria BAE76049 http://www.ensemblgenomes.org/id/BAE76049 EnsemblBacteria BAE76049 http://www.ensemblgenomes.org/id/BAE76049 EnsemblBacteria BAE76049 http://www.ensemblgenomes.org/id/BAE76049 EnsemblBacteria b0259 http://www.ensemblgenomes.org/id/b0259 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GeneID 944917 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944917 GeneID 944941 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944941 GeneID 945896 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945896 GeneID 946163 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946163 GeneID 946577 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946577 GeneID 947516 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947516 GeneID 947743 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947743 GeneID 948015 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948015 GeneID 949121 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949121 InParanoid P0CE49 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CE49 InterPro IPR002559 http://www.ebi.ac.uk/interpro/entry/IPR002559 InterPro IPR008490 http://www.ebi.ac.uk/interpro/entry/IPR008490 KEGG_Gene ecj:JW0250 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0250 KEGG_Gene eco:b0259 http://www.genome.jp/dbget-bin/www_bget?eco:b0259 KEGG_Gene eco:b0552 http://www.genome.jp/dbget-bin/www_bget?eco:b0552 KEGG_Gene eco:b0656 http://www.genome.jp/dbget-bin/www_bget?eco:b0656 KEGG_Gene eco:b1331 http://www.genome.jp/dbget-bin/www_bget?eco:b1331 KEGG_Gene eco:b2030 http://www.genome.jp/dbget-bin/www_bget?eco:b2030 KEGG_Gene eco:b2192 http://www.genome.jp/dbget-bin/www_bget?eco:b2192 KEGG_Gene eco:b2982 http://www.genome.jp/dbget-bin/www_bget?eco:b2982 KEGG_Gene eco:b3218 http://www.genome.jp/dbget-bin/www_bget?eco:b3218 KEGG_Gene eco:b3505 http://www.genome.jp/dbget-bin/www_bget?eco:b3505 PSORT swissprot:INSH1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSH1_ECOLI PSORT-B swissprot:INSH1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSH1_ECOLI PSORT2 swissprot:INSH1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSH1_ECOLI Pfam PF01609 http://pfam.xfam.org/family/PF01609 Pfam PF05598 http://pfam.xfam.org/family/PF05598 Phobius swissprot:INSH1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSH1_ECOLI PhylomeDB P0CE49 http://phylomedb.org/?seqid=P0CE49 ProteinModelPortal P0CE49 http://www.proteinmodelportal.org/query/uniprot/P0CE49 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6269958 http://www.ncbi.nlm.nih.gov/pubmed/6269958 PubMed 6269959 http://www.ncbi.nlm.nih.gov/pubmed/6269959 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414793 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414793 RefSeq NP_415084 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415084 RefSeq NP_415189 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415189 RefSeq NP_415847 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415847 RefSeq NP_416535 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416535 RefSeq NP_416696 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416696 RefSeq NP_417456 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417456 RefSeq NP_417685 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417685 RefSeq NP_417962 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417962 SMR P0CE49 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0CE49 STRING 511145.b3505 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3505&targetmode=cogs UniProtKB INSH1_ECOLI http://www.uniprot.org/uniprot/INSH1_ECOLI UniProtKB-AC P0CE49 http://www.uniprot.org/uniprot/P0CE49 charge swissprot:INSH1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSH1_ECOLI eggNOG COG3039 http://eggnogapi.embl.de/nog_data/html/tree/COG3039 eggNOG ENOG4105F2I http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F2I epestfind swissprot:INSH1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSH1_ECOLI garnier swissprot:INSH1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSH1_ECOLI helixturnhelix swissprot:INSH1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSH1_ECOLI hmoment swissprot:INSH1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSH1_ECOLI iep swissprot:INSH1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSH1_ECOLI inforesidue swissprot:INSH1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSH1_ECOLI octanol swissprot:INSH1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSH1_ECOLI pepcoil swissprot:INSH1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSH1_ECOLI pepdigest swissprot:INSH1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSH1_ECOLI pepinfo swissprot:INSH1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSH1_ECOLI pepnet swissprot:INSH1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSH1_ECOLI pepstats swissprot:INSH1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSH1_ECOLI pepwheel swissprot:INSH1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSH1_ECOLI pepwindow swissprot:INSH1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSH1_ECOLI sigcleave swissprot:INSH1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSH1_ECOLI ## Database ID URL or Descriptions # AltName ALF1_ECOLI Fructose-bisphosphate aldolase class I # BioGrid 4261525 4 # CATALYTIC ACTIVITY ALF1_ECOLI D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. # CAUTION Was originally (Ref.1) thought to be a dehydrin. {ECO 0000305}. # ENZYME REGULATION ALF1_ECOLI Activated by citrate. # EcoGene EG14062 fbaB # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0004332 fructose-bisphosphate aldolase activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IPI:EcoCyc. # GO_process GO:0006096 glycolytic process; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.20.20.70 -; 1. # INTERACTION ALF1_ECOLI Self; NbExp=2; IntAct=EBI-545269, EBI-545269; # IntAct P0A991 5 # InterPro IPR002915 DeoC/FbaB/lacD_aldolase # InterPro IPR013785 Aldolase_TIM # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00010 Glycolysis / Gluconeogenesis # KEGG_Pathway ko00030 Pentose phosphate pathway # KEGG_Pathway ko00051 Fructose and mannose metabolism # KEGG_Pathway ko00680 Methane metabolism # KEGG_Pathway ko00710 Carbon fixation in photosynthetic organisms # MASS SPECTROMETRY Mass=37979.3; Method=MALDI; Range=2-350; Evidence={ECO:0000269|PubMed 9531482}; # Organism ALF1_ECOLI Escherichia coli (strain K12) # PATRIC 32119527 VBIEscCol129921_2174 # Pfam PF01791 DeoC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ALF1_ECOLI Fructose-bisphosphate aldolase class 1 # RefSeq NP_416600 NC_000913.3 # RefSeq WP_000129551 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18249.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the DeoC/FbaB aldolase family. FbaB subfamily. {ECO 0000305}. # SMART SM01133 DeoC # SUBCELLULAR LOCATION ALF1_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT ALF1_ECOLI Homooctamer or homodecamer. # eggNOG COG1830 LUCA # eggNOG ENOG4105EIE Bacteria BLAST swissprot:ALF1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ALF1_ECOLI BioCyc ECOL316407:JW5344-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5344-MONOMER BioCyc EcoCyc:FRUCBISALD-CLASSI-MONOMER http://biocyc.org/getid?id=EcoCyc:FRUCBISALD-CLASSI-MONOMER BioCyc MetaCyc:FRUCBISALD-CLASSI-MONOMER http://biocyc.org/getid?id=MetaCyc:FRUCBISALD-CLASSI-MONOMER COG COG1830 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1830 DIP DIP-36197N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36197N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj3310437 http://dx.doi.org/10.1042/bj3310437 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.1.2.13 http://www.genome.jp/dbget-bin/www_bget?EC:4.1.2.13 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73760 http://www.ebi.ac.uk/ena/data/view/U73760 ENZYME 4.1.2.13 http://enzyme.expasy.org/EC/4.1.2.13 EchoBASE EB3815 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3815 EcoGene EG14062 http://www.ecogene.org/geneInfo.php?eg_id=EG14062 EnsemblBacteria AAC75158 http://www.ensemblgenomes.org/id/AAC75158 EnsemblBacteria AAC75158 http://www.ensemblgenomes.org/id/AAC75158 EnsemblBacteria BAE76584 http://www.ensemblgenomes.org/id/BAE76584 EnsemblBacteria BAE76584 http://www.ensemblgenomes.org/id/BAE76584 EnsemblBacteria BAE76584 http://www.ensemblgenomes.org/id/BAE76584 EnsemblBacteria b2097 http://www.ensemblgenomes.org/id/b2097 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0004332 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004332 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0006096 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006096 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 946632 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946632 HOGENOM HOG000224791 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000224791&db=HOGENOM6 InParanoid P0A991 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A991 IntAct P0A991 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A991* IntEnz 4.1.2.13 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.2.13 InterPro IPR002915 http://www.ebi.ac.uk/interpro/entry/IPR002915 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5344 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5344 KEGG_Gene eco:b2097 http://www.genome.jp/dbget-bin/www_bget?eco:b2097 KEGG_Orthology KO:K11645 http://www.genome.jp/dbget-bin/www_bget?KO:K11645 KEGG_Pathway ko00010 http://www.genome.jp/kegg-bin/show_pathway?ko00010 KEGG_Pathway ko00030 http://www.genome.jp/kegg-bin/show_pathway?ko00030 KEGG_Pathway ko00051 http://www.genome.jp/kegg-bin/show_pathway?ko00051 KEGG_Pathway ko00680 http://www.genome.jp/kegg-bin/show_pathway?ko00680 KEGG_Pathway ko00710 http://www.genome.jp/kegg-bin/show_pathway?ko00710 KEGG_Reaction rn:R01068 http://www.genome.jp/dbget-bin/www_bget?rn:R01068 KEGG_Reaction rn:R01070 http://www.genome.jp/dbget-bin/www_bget?rn:R01070 KEGG_Reaction rn:R01829 http://www.genome.jp/dbget-bin/www_bget?rn:R01829 KEGG_Reaction rn:R02568 http://www.genome.jp/dbget-bin/www_bget?rn:R02568 OMA IYFGSPE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IYFGSPE PSORT swissprot:ALF1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ALF1_ECOLI PSORT-B swissprot:ALF1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ALF1_ECOLI PSORT2 swissprot:ALF1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ALF1_ECOLI Pfam PF01791 http://pfam.xfam.org/family/PF01791 Phobius swissprot:ALF1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ALF1_ECOLI PhylomeDB P0A991 http://phylomedb.org/?seqid=P0A991 ProteinModelPortal P0A991 http://www.proteinmodelportal.org/query/uniprot/P0A991 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9531482 http://www.ncbi.nlm.nih.gov/pubmed/9531482 RefSeq NP_416600 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416600 RefSeq WP_000129551 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000129551 SMART SM01133 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01133 STRING 511145.b2097 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2097&targetmode=cogs STRING COG1830 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1830&targetmode=cogs UniProtKB ALF1_ECOLI http://www.uniprot.org/uniprot/ALF1_ECOLI UniProtKB-AC P0A991 http://www.uniprot.org/uniprot/P0A991 charge swissprot:ALF1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ALF1_ECOLI eggNOG COG1830 http://eggnogapi.embl.de/nog_data/html/tree/COG1830 eggNOG ENOG4105EIE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EIE epestfind swissprot:ALF1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ALF1_ECOLI garnier swissprot:ALF1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ALF1_ECOLI helixturnhelix swissprot:ALF1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ALF1_ECOLI hmoment swissprot:ALF1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ALF1_ECOLI iep swissprot:ALF1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ALF1_ECOLI inforesidue swissprot:ALF1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ALF1_ECOLI octanol swissprot:ALF1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ALF1_ECOLI pepcoil swissprot:ALF1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ALF1_ECOLI pepdigest swissprot:ALF1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ALF1_ECOLI pepinfo swissprot:ALF1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ALF1_ECOLI pepnet swissprot:ALF1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ALF1_ECOLI pepstats swissprot:ALF1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ALF1_ECOLI pepwheel swissprot:ALF1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ALF1_ECOLI pepwindow swissprot:ALF1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ALF1_ECOLI sigcleave swissprot:ALF1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ALF1_ECOLI ## Database ID URL or Descriptions # BioGrid 4261351 123 # EcoGene EG11984 wbbJ # FUNCTION WBBJ_ECOLI Putative O-acetyltransferase that transfers an O-acetyl group to the O antigen. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0016746 transferase activity, transferring acyl groups; IEA:UniProtKB-KW. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # IntAct P37750 7 # InterPro IPR001451 Hexapep # InterPro IPR011004 Trimer_LpxA-like # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # Organism WBBJ_ECOLI Escherichia coli (strain K12) # PATHWAY WBBJ_ECOLI Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. # PIR H64968 H64968 # Pfam PF00132 Hexapep # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName WBBJ_ECOLI Putative lipopolysaccharide biosynthesis O-acetyl transferase WbbJ # RefSeq NP_416537 NC_000913.3 # RefSeq WP_000601187 NZ_LN832404.1 # SIMILARITY Belongs to the transferase hexapeptide repeat family. {ECO 0000305}. # SUPFAM SSF51161 SSF51161 # eggNOG COG0110 LUCA # eggNOG ENOG4108UW5 Bacteria BLAST swissprot:WBBJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:WBBJ_ECOLI BioCyc ECOL316407:JW2018-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2018-MONOMER BioCyc EcoCyc:EG11984-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11984-MONOMER COG COG0110 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0110 DIP DIP-11115N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11115N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U03041 http://www.ebi.ac.uk/ena/data/view/U03041 EMBL U09876 http://www.ebi.ac.uk/ena/data/view/U09876 ENZYME 2.3.1.- http://enzyme.expasy.org/EC/2.3.1.- EchoBASE EB1927 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1927 EcoGene EG11984 http://www.ecogene.org/geneInfo.php?eg_id=EG11984 EnsemblBacteria AAC75094 http://www.ensemblgenomes.org/id/AAC75094 EnsemblBacteria AAC75094 http://www.ensemblgenomes.org/id/AAC75094 EnsemblBacteria BAA15875 http://www.ensemblgenomes.org/id/BAA15875 EnsemblBacteria BAA15875 http://www.ensemblgenomes.org/id/BAA15875 EnsemblBacteria BAA15875 http://www.ensemblgenomes.org/id/BAA15875 EnsemblBacteria b2033 http://www.ensemblgenomes.org/id/b2033 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 946556 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946556 HOGENOM HOG000049435 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000049435&db=HOGENOM6 InParanoid P37750 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37750 IntAct P37750 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37750* IntEnz 2.3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1 InterPro IPR001451 http://www.ebi.ac.uk/interpro/entry/IPR001451 InterPro IPR011004 http://www.ebi.ac.uk/interpro/entry/IPR011004 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Gene ecj:JW2018 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2018 KEGG_Gene eco:b2033 http://www.genome.jp/dbget-bin/www_bget?eco:b2033 KEGG_Orthology KO:K08280 http://www.genome.jp/dbget-bin/www_bget?KO:K08280 OMA VHIGAIE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VHIGAIE PSORT swissprot:WBBJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:WBBJ_ECOLI PSORT-B swissprot:WBBJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:WBBJ_ECOLI PSORT2 swissprot:WBBJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:WBBJ_ECOLI Pfam PF00132 http://pfam.xfam.org/family/PF00132 Phobius swissprot:WBBJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:WBBJ_ECOLI PhylomeDB P37750 http://phylomedb.org/?seqid=P37750 ProteinModelPortal P37750 http://www.proteinmodelportal.org/query/uniprot/P37750 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7517390 http://www.ncbi.nlm.nih.gov/pubmed/7517390 PubMed 7517391 http://www.ncbi.nlm.nih.gov/pubmed/7517391 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416537 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416537 RefSeq WP_000601187 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000601187 SMR P37750 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37750 STRING 511145.b2033 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2033&targetmode=cogs STRING COG0110 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0110&targetmode=cogs SUPFAM SSF51161 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51161 UniProtKB WBBJ_ECOLI http://www.uniprot.org/uniprot/WBBJ_ECOLI UniProtKB-AC P37750 http://www.uniprot.org/uniprot/P37750 charge swissprot:WBBJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:WBBJ_ECOLI eggNOG COG0110 http://eggnogapi.embl.de/nog_data/html/tree/COG0110 eggNOG ENOG4108UW5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UW5 epestfind swissprot:WBBJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:WBBJ_ECOLI garnier swissprot:WBBJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:WBBJ_ECOLI helixturnhelix swissprot:WBBJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:WBBJ_ECOLI hmoment swissprot:WBBJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:WBBJ_ECOLI iep swissprot:WBBJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:WBBJ_ECOLI inforesidue swissprot:WBBJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:WBBJ_ECOLI octanol swissprot:WBBJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:WBBJ_ECOLI pepcoil swissprot:WBBJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:WBBJ_ECOLI pepdigest swissprot:WBBJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:WBBJ_ECOLI pepinfo swissprot:WBBJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:WBBJ_ECOLI pepnet swissprot:WBBJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:WBBJ_ECOLI pepstats swissprot:WBBJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:WBBJ_ECOLI pepwheel swissprot:WBBJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:WBBJ_ECOLI pepwindow swissprot:WBBJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:WBBJ_ECOLI sigcleave swissprot:WBBJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:WBBJ_ECOLI ## Database ID URL or Descriptions # BRENDA 2.5.1.74 2026 # BioGrid 4261778 7 # CATALYTIC ACTIVITY MENA_ECOLI An all-trans-polyprenyl diphosphate + 1,4- dihydroxy-2-naphthoate = a demethylmenaquinol + diphosphate + CO(2). {ECO 0000255|HAMAP-Rule MF_01937, ECO 0000269|PubMed 9573170}. # EcoGene EG11880 menA # FUNCTION MENA_ECOLI Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages the removal of the carboxyl group of DHNA as CO(2), the attachment of the isoprenoid side chain, and a quinol-to-quinone oxidation, which is thought to be spontaneous. {ECO 0000269|PubMed 9573170}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IEA:UniProtKB-HAMAP. # GO_component GO:0016020 membrane; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0046428 1,4-dihydroxy-2-naphthoate octaprenyltransferase activity; IDA:EcoCyc. # GO_process GO:0009234 menaquinone biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # HAMAP MF_01937 MenA_1 # InterPro IPR000537 UbiA_prenyltransferase # InterPro IPR004657 MenA # InterPro IPR026046 UBIAD1 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01006 Prenyltransferases # KEGG_Pathway ko00130 Ubiquinone and other terpenoid-quinone biosynthesis # Organism MENA_ECOLI Escherichia coli (strain K12) # PATHWAY MENA_ECOLI Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate step 1/2. {ECO 0000255|HAMAP-Rule MF_01937, ECO 0000269|PubMed 9573170}. # PATRIC 32123375 VBIEscCol129921_4048 # PIR S40873 S40873 # PIRSF PIRSF005355 UBIAD1 # Pfam PF01040 UbiA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 1,4-dihydroxy-2-naphthoate octaprenyltransferase {ECO:0000255|HAMAP-Rule MF_01937} # RefSeq NP_418365 NC_000913.3 # RefSeq WP_000139496 NZ_LN832404.1 # SIMILARITY Belongs to the MenA family. Type 1 subfamily. {ECO:0000255|HAMAP-Rule MF_01937, ECO:0000305}. # SUBCELLULAR LOCATION MENA_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01937, ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255|HAMAP-Rule MF_01937, ECO 0000269|PubMed 15919996}. # UniPathway UPA00079 UER00168 # eggNOG COG1575 LUCA # eggNOG ENOG4105EIS Bacteria BLAST swissprot:MENA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MENA_ECOLI BioCyc ECOL316407:JW3901-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3901-MONOMER BioCyc EcoCyc:DMK-MONOMER http://biocyc.org/getid?id=EcoCyc:DMK-MONOMER BioCyc MetaCyc:DMK-MONOMER http://biocyc.org/getid?id=MetaCyc:DMK-MONOMER COG COG1575 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1575 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.5.1.74 {ECO:0000255|HAMAP-Rule:MF_01937, ECO:0000269|PubMed:9573170} http://www.genome.jp/dbget-bin/www_bget?EC:2.5.1.74 {ECO:0000255|HAMAP-Rule:MF_01937, ECO:0000269|PubMed:9573170} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U56082 http://www.ebi.ac.uk/ena/data/view/U56082 ENZYME 2.5.1.74 {ECO:0000255|HAMAP-Rule:MF_01937, ECO:0000269|PubMed:9573170} http://enzyme.expasy.org/EC/2.5.1.74 {ECO:0000255|HAMAP-Rule:MF_01937, ECO:0000269|PubMed:9573170} EchoBASE EB1826 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1826 EcoGene EG11880 http://www.ecogene.org/geneInfo.php?eg_id=EG11880 EnsemblBacteria AAC76912 http://www.ensemblgenomes.org/id/AAC76912 EnsemblBacteria AAC76912 http://www.ensemblgenomes.org/id/AAC76912 EnsemblBacteria BAE77380 http://www.ensemblgenomes.org/id/BAE77380 EnsemblBacteria BAE77380 http://www.ensemblgenomes.org/id/BAE77380 EnsemblBacteria BAE77380 http://www.ensemblgenomes.org/id/BAE77380 EnsemblBacteria b3930 http://www.ensemblgenomes.org/id/b3930 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0046428 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046428 GO_process GO:0009234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009234 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016765 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GeneID 948418 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948418 HAMAP MF_01937 http://hamap.expasy.org/unirule/MF_01937 HOGENOM HOG000028297 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000028297&db=HOGENOM6 InParanoid P32166 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32166 IntEnz 2.5.1.74 {ECO:0000255|HAMAP-Rule:MF_01937, ECO:0000269|PubMed:9573170} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.5.1.74 {ECO:0000255|HAMAP-Rule:MF_01937, ECO:0000269|PubMed:9573170} InterPro IPR000537 http://www.ebi.ac.uk/interpro/entry/IPR000537 InterPro IPR004657 http://www.ebi.ac.uk/interpro/entry/IPR004657 InterPro IPR026046 http://www.ebi.ac.uk/interpro/entry/IPR026046 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01006 http://www.genome.jp/dbget-bin/www_bget?ko01006 KEGG_Gene ecj:JW3901 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3901 KEGG_Gene eco:b3930 http://www.genome.jp/dbget-bin/www_bget?eco:b3930 KEGG_Orthology KO:K02548 http://www.genome.jp/dbget-bin/www_bget?KO:K02548 KEGG_Pathway ko00130 http://www.genome.jp/kegg-bin/show_pathway?ko00130 KEGG_Reaction rn:R05617 http://www.genome.jp/dbget-bin/www_bget?rn:R05617 KEGG_Reaction rn:R06858 http://www.genome.jp/dbget-bin/www_bget?rn:R06858 OMA MGLFYVF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MGLFYVF PSORT swissprot:MENA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MENA_ECOLI PSORT-B swissprot:MENA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MENA_ECOLI PSORT2 swissprot:MENA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MENA_ECOLI Pfam PF01040 http://pfam.xfam.org/family/PF01040 Phobius swissprot:MENA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MENA_ECOLI PhylomeDB P32166 http://phylomedb.org/?seqid=P32166 ProteinModelPortal P32166 http://www.proteinmodelportal.org/query/uniprot/P32166 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9573170 http://www.ncbi.nlm.nih.gov/pubmed/9573170 RefSeq NP_418365 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418365 RefSeq WP_000139496 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000139496 STRING 511145.b3930 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3930&targetmode=cogs STRING COG1575 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1575&targetmode=cogs UniProtKB MENA_ECOLI http://www.uniprot.org/uniprot/MENA_ECOLI UniProtKB-AC P32166 http://www.uniprot.org/uniprot/P32166 charge swissprot:MENA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MENA_ECOLI eggNOG COG1575 http://eggnogapi.embl.de/nog_data/html/tree/COG1575 eggNOG ENOG4105EIS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EIS epestfind swissprot:MENA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MENA_ECOLI garnier swissprot:MENA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MENA_ECOLI helixturnhelix swissprot:MENA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MENA_ECOLI hmoment swissprot:MENA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MENA_ECOLI iep swissprot:MENA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MENA_ECOLI inforesidue swissprot:MENA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MENA_ECOLI octanol swissprot:MENA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MENA_ECOLI pepcoil swissprot:MENA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MENA_ECOLI pepdigest swissprot:MENA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MENA_ECOLI pepinfo swissprot:MENA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MENA_ECOLI pepnet swissprot:MENA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MENA_ECOLI pepstats swissprot:MENA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MENA_ECOLI pepwheel swissprot:MENA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MENA_ECOLI pepwindow swissprot:MENA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MENA_ECOLI sigcleave swissprot:MENA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MENA_ECOLI ## Database ID URL or Descriptions # BioGrid 4263257 216 # CDD cd06174 MFS # EcoGene EG11842 yihP # FUNCTION YIHP_ECOLI Could be involved in the export of 2,3-dihydroxypropane- 1-sulfonate (DHPS). {ECO 0000269|PubMed 24463506}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015293 symporter activity; IEA:UniProtKB-KW. # GO_process GO:0006814 sodium ion transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR001927 Na/Gal_symport # InterPro IPR018043 Na/Gal_symport_CS # InterPro IPR020846 MFS_dom # Organism YIHP_ECOLI Escherichia coli (strain K12) # PATRIC 32123257 VBIEscCol129921_3989 # PIR H65192 H65192 # PROSITE PS00872 NA_GALACTOSIDE_SYMP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIHP_ECOLI Putative 2,3-dihydroxypropane-1-sulfonate exporter # RefSeq NP_418313 NC_000913.3 # RefSeq WP_000018380 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB03010.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAE77432.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the sodium:galactoside symporter (TC 2.A.2) family. {ECO 0000305}. # SUBCELLULAR LOCATION YIHP_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.2.3:the glycoside-pentoside-hexuronide (gph) cation symporter family # TIGRFAMs TIGR00792 gph # eggNOG COG2211 LUCA # eggNOG ENOG4105CT4 Bacteria BLAST swissprot:YIHP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIHP_ECOLI BioCyc ECOL316407:JW3848-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3848-MONOMER BioCyc EcoCyc:YIHP-MONOMER http://biocyc.org/getid?id=EcoCyc:YIHP-MONOMER COG COG2211 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2211 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature12947 http://dx.doi.org/10.1038/nature12947 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1788 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1788 EcoGene EG11842 http://www.ecogene.org/geneInfo.php?eg_id=EG11842 EnsemblBacteria AAC76874 http://www.ensemblgenomes.org/id/AAC76874 EnsemblBacteria AAC76874 http://www.ensemblgenomes.org/id/AAC76874 EnsemblBacteria BAE77432 http://www.ensemblgenomes.org/id/BAE77432 EnsemblBacteria BAE77432 http://www.ensemblgenomes.org/id/BAE77432 EnsemblBacteria BAE77432 http://www.ensemblgenomes.org/id/BAE77432 EnsemblBacteria b3877 http://www.ensemblgenomes.org/id/b3877 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015293 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293 GO_process GO:0006814 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948371 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948371 HOGENOM HOG000222020 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000222020&db=HOGENOM6 InParanoid P32137 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32137 IntAct P32137 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32137* InterPro IPR001927 http://www.ebi.ac.uk/interpro/entry/IPR001927 InterPro IPR018043 http://www.ebi.ac.uk/interpro/entry/IPR018043 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Gene ecj:JW3848 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3848 KEGG_Gene eco:b3877 http://www.genome.jp/dbget-bin/www_bget?eco:b3877 KEGG_Orthology KO:K03292 http://www.genome.jp/dbget-bin/www_bget?KO:K03292 OMA AYGMGDL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AYGMGDL PROSITE PS00872 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00872 PSORT swissprot:YIHP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIHP_ECOLI PSORT-B swissprot:YIHP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIHP_ECOLI PSORT2 swissprot:YIHP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIHP_ECOLI Phobius swissprot:YIHP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIHP_ECOLI PhylomeDB P32137 http://phylomedb.org/?seqid=P32137 ProteinModelPortal P32137 http://www.proteinmodelportal.org/query/uniprot/P32137 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 24463506 http://www.ncbi.nlm.nih.gov/pubmed/24463506 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418313 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418313 RefSeq WP_000018380 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000018380 STRING 511145.b3877 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3877&targetmode=cogs STRING COG2211 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2211&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.2.3 http://www.tcdb.org/search/result.php?tc=2.A.2.3 TIGRFAMs TIGR00792 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00792 UniProtKB YIHP_ECOLI http://www.uniprot.org/uniprot/YIHP_ECOLI UniProtKB-AC P32137 http://www.uniprot.org/uniprot/P32137 charge swissprot:YIHP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIHP_ECOLI eggNOG COG2211 http://eggnogapi.embl.de/nog_data/html/tree/COG2211 eggNOG ENOG4105CT4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CT4 epestfind swissprot:YIHP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIHP_ECOLI garnier swissprot:YIHP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIHP_ECOLI helixturnhelix swissprot:YIHP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIHP_ECOLI hmoment swissprot:YIHP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIHP_ECOLI iep swissprot:YIHP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIHP_ECOLI inforesidue swissprot:YIHP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIHP_ECOLI octanol swissprot:YIHP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIHP_ECOLI pepcoil swissprot:YIHP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIHP_ECOLI pepdigest swissprot:YIHP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIHP_ECOLI pepinfo swissprot:YIHP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIHP_ECOLI pepnet swissprot:YIHP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIHP_ECOLI pepstats swissprot:YIHP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIHP_ECOLI pepwheel swissprot:YIHP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIHP_ECOLI pepwindow swissprot:YIHP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIHP_ECOLI sigcleave swissprot:YIHP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIHP_ECOLI ## Database ID URL or Descriptions # BioGrid 4263406 8 # DISRUPTION PHENOTYPE Mutation confers sensitivity to SDS-EDTA and leads to accumulation of phospholipid in the outer leaflet of the outer membrane. {ECO:0000269|PubMed 19383799}. # EcoGene EG12800 mlaE # FUNCTION MLAE_ECOLI Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. {ECO 0000269|PubMed 19383799}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IEA:InterPro. # GO_function GO:0005543 phospholipid binding; IMP:EcoCyc. # GO_function GO:0005548 phospholipid transporter activity; IMP:EcoCyc. # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008289 lipid binding # GOslim_function GO:0043167 ion binding # InterPro IPR003453 ABC_MlaE_Proteobac # InterPro IPR030802 Permease_MalE # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00210 Putative ABC transport system # KEGG_Brite ko02000 Transporters # Organism MLAE_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30188 PTHR30188 # PATRIC 32121808 VBIEscCol129921_3288 # PIR D65110 D65110 # Pfam PF02405 MlaE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Probable phospholipid ABC transporter permease protein MlaE {ECO 0000305} # RefSeq NP_417661 NC_000913.3 # RefSeq WP_000925795 NZ_LN832404.1 # SIMILARITY Belongs to the MlaE permease family. {ECO 0000305}. # SUBCELLULAR LOCATION MLAE_ECOLI Cell inner membrane {ECO 0000269|PubMed 19383799}; Multi-pass membrane protein {ECO 0000255, ECO 0000269|PubMed 19383799}. # SUBUNIT The complex is composed of two ATP-binding proteins (MlaF), two transmembrane proteins (MlaE), two cytoplasmic solute- binding proteins (MlaB) and a periplamic solute-binding protein (MlaD). {ECO:0000305|PubMed 19383799}. # TCDB 3.A.1.27 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR00056 TIGR00056 # eggNOG COG0767 LUCA # eggNOG ENOG4105CY3 Bacteria BLAST swissprot:MLAE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MLAE_ECOLI BioCyc ECOL316407:JW3161-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3161-MONOMER BioCyc EcoCyc:YRBE-MONOMER http://biocyc.org/getid?id=EcoCyc:YRBE-MONOMER COG COG0767 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0767 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0903229106 http://dx.doi.org/10.1073/pnas.0903229106 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2652 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2652 EcoGene EG12800 http://www.ecogene.org/geneInfo.php?eg_id=EG12800 EnsemblBacteria AAC76226 http://www.ensemblgenomes.org/id/AAC76226 EnsemblBacteria AAC76226 http://www.ensemblgenomes.org/id/AAC76226 EnsemblBacteria BAE77238 http://www.ensemblgenomes.org/id/BAE77238 EnsemblBacteria BAE77238 http://www.ensemblgenomes.org/id/BAE77238 EnsemblBacteria BAE77238 http://www.ensemblgenomes.org/id/BAE77238 EnsemblBacteria b3194 http://www.ensemblgenomes.org/id/b3194 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0005543 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005543 GO_function GO:0005548 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005548 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GeneID 947732 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947732 HOGENOM HOG000255130 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000255130&db=HOGENOM6 InParanoid P64606 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P64606 InterPro IPR003453 http://www.ebi.ac.uk/interpro/entry/IPR003453 InterPro IPR030802 http://www.ebi.ac.uk/interpro/entry/IPR030802 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3161 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3161 KEGG_Gene eco:b3194 http://www.genome.jp/dbget-bin/www_bget?eco:b3194 KEGG_Orthology KO:K02066 http://www.genome.jp/dbget-bin/www_bget?KO:K02066 OMA QLMESGP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QLMESGP PANTHER PTHR30188 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30188 PSORT swissprot:MLAE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MLAE_ECOLI PSORT-B swissprot:MLAE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MLAE_ECOLI PSORT2 swissprot:MLAE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MLAE_ECOLI Pfam PF02405 http://pfam.xfam.org/family/PF02405 Phobius swissprot:MLAE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MLAE_ECOLI PhylomeDB P64606 http://phylomedb.org/?seqid=P64606 ProteinModelPortal P64606 http://www.proteinmodelportal.org/query/uniprot/P64606 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19383799 http://www.ncbi.nlm.nih.gov/pubmed/19383799 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417661 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417661 RefSeq WP_000925795 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000925795 STRING 511145.b3194 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3194&targetmode=cogs STRING COG0767 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0767&targetmode=cogs TCDB 3.A.1.27 http://www.tcdb.org/search/result.php?tc=3.A.1.27 TIGRFAMs TIGR00056 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00056 UniProtKB MLAE_ECOLI http://www.uniprot.org/uniprot/MLAE_ECOLI UniProtKB-AC P64606 http://www.uniprot.org/uniprot/P64606 charge swissprot:MLAE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MLAE_ECOLI eggNOG COG0767 http://eggnogapi.embl.de/nog_data/html/tree/COG0767 eggNOG ENOG4105CY3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CY3 epestfind swissprot:MLAE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MLAE_ECOLI garnier swissprot:MLAE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MLAE_ECOLI helixturnhelix swissprot:MLAE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MLAE_ECOLI hmoment swissprot:MLAE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MLAE_ECOLI iep swissprot:MLAE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MLAE_ECOLI inforesidue swissprot:MLAE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MLAE_ECOLI octanol swissprot:MLAE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MLAE_ECOLI pepcoil swissprot:MLAE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MLAE_ECOLI pepdigest swissprot:MLAE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MLAE_ECOLI pepinfo swissprot:MLAE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MLAE_ECOLI pepnet swissprot:MLAE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MLAE_ECOLI pepstats swissprot:MLAE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MLAE_ECOLI pepwheel swissprot:MLAE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MLAE_ECOLI pepwindow swissprot:MLAE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MLAE_ECOLI sigcleave swissprot:MLAE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MLAE_ECOLI ## Database ID URL or Descriptions # BioGrid 4261187 15 # CAUTION A pseudogene in strain MG1655 / ATCC 700926 due to a recent laboratory-derived single nucleotide deletion, but not its parent MG1655 / ATCC 47076. {ECO:0000305|PubMed 22081388}. # EcoGene EG10400 glpR # FUNCTION GLPR_ECOLI Repressor of the glycerol-3-phosphate regulon. # GO_component GO:0005622 intracellular; IEA:InterPro. # GO_function GO:0000986 bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding; IDA:EcoCyc. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006071 glycerol metabolic process; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_component GO:0005622 intracellular # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.10.10 -; 1. # INTERACTION GLPR_ECOLI P05847 ttdA; NbExp=2; IntAct=EBI-1123685, EBI-1113137; # IntAct P0ACL0 2 # InterPro IPR001034 DeoR_HTH # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR014036 DeoR_C # InterPro IPR018356 Tscrpt_reg_HTH_DeoR_CS # Organism GLPR_ECOLI Escherichia coli (strain K12) # PATRIC 32122282 VBIEscCol129921_3518 # PIR B65138 B65138 # PRINTS PR00037 HTHLACR # PROSITE PS00894 HTH_DEOR_1 # PROSITE PS51000 HTH_DEOR_2 # Pfam PF00455 DeoRC # Pfam PF08220 HTH_DeoR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLPR_ECOLI Glycerol-3-phosphate regulon repressor # RefSeq WP_000815099 NZ_CP014272.1 # SEQUENCE CAUTION Sequence=CAA30399.1; Type=Frameshift; Positions=107, 148, 165, 233; Evidence={ECO 0000305}; # SIMILARITY Contains 1 HTH deoR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00349}. # SMART SM00420 HTH_DEOR # SUPFAM SSF46785 SSF46785 # eggNOG COG1349 LUCA # eggNOG ENOG4105E98 Bacteria BLAST swissprot:GLPR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLPR_ECOLI BioCyc ECOL316407:JW3386-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3386-MONOMER BioCyc EcoCyc:PD03576 http://biocyc.org/getid?id=EcoCyc:PD03576 DIP DIP-9798N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9798N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/16.15.7732 http://dx.doi.org/10.1093/nar/16.15.7732 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.06087-11 http://dx.doi.org/10.1128/JB.06087-11 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M96795 http://www.ebi.ac.uk/ena/data/view/M96795 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X07520 http://www.ebi.ac.uk/ena/data/view/X07520 EchoBASE EB0395 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0395 EcoGene EG10400 http://www.ecogene.org/geneInfo.php?eg_id=EG10400 EnsemblBacteria BAE77869 http://www.ensemblgenomes.org/id/BAE77869 EnsemblBacteria BAE77869 http://www.ensemblgenomes.org/id/BAE77869 EnsemblBacteria BAE77869 http://www.ensemblgenomes.org/id/BAE77869 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_function GO:0000986 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000986 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006071 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 HOGENOM HOG000224685 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000224685&db=HOGENOM6 InParanoid P0ACL0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACL0 IntAct P0ACL0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACL0* InterPro IPR001034 http://www.ebi.ac.uk/interpro/entry/IPR001034 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR014036 http://www.ebi.ac.uk/interpro/entry/IPR014036 InterPro IPR018356 http://www.ebi.ac.uk/interpro/entry/IPR018356 KEGG_Gene ecj:JW3386 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3386 OMA NLAYEAR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NLAYEAR PRINTS PR00037 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00037 PROSITE PS00894 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00894 PROSITE PS51000 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51000 PSORT swissprot:GLPR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLPR_ECOLI PSORT-B swissprot:GLPR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLPR_ECOLI PSORT2 swissprot:GLPR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLPR_ECOLI Pfam PF00455 http://pfam.xfam.org/family/PF00455 Pfam PF08220 http://pfam.xfam.org/family/PF08220 Phobius swissprot:GLPR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLPR_ECOLI PhylomeDB P0ACL0 http://phylomedb.org/?seqid=P0ACL0 ProteinModelPortal P0ACL0 http://www.proteinmodelportal.org/query/uniprot/P0ACL0 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22081388 http://www.ncbi.nlm.nih.gov/pubmed/22081388 PubMed 3045764 http://www.ncbi.nlm.nih.gov/pubmed/3045764 PubMed 8955387 http://www.ncbi.nlm.nih.gov/pubmed/8955387 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq WP_000815099 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000815099 SMART SM00420 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00420 STRING 511145.b3423 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3423&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SWISS-2DPAGE P0ACL0 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0ACL0 UniProtKB GLPR_ECOLI http://www.uniprot.org/uniprot/GLPR_ECOLI UniProtKB-AC P0ACL0 http://www.uniprot.org/uniprot/P0ACL0 charge swissprot:GLPR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLPR_ECOLI eggNOG COG1349 http://eggnogapi.embl.de/nog_data/html/tree/COG1349 eggNOG ENOG4105E98 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E98 epestfind swissprot:GLPR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLPR_ECOLI garnier swissprot:GLPR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLPR_ECOLI helixturnhelix swissprot:GLPR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLPR_ECOLI hmoment swissprot:GLPR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLPR_ECOLI iep swissprot:GLPR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLPR_ECOLI inforesidue swissprot:GLPR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLPR_ECOLI octanol swissprot:GLPR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLPR_ECOLI pepcoil swissprot:GLPR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLPR_ECOLI pepdigest swissprot:GLPR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLPR_ECOLI pepinfo swissprot:GLPR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLPR_ECOLI pepnet swissprot:GLPR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLPR_ECOLI pepstats swissprot:GLPR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLPR_ECOLI pepwheel swissprot:GLPR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLPR_ECOLI pepwindow swissprot:GLPR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLPR_ECOLI sigcleave swissprot:GLPR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLPR_ECOLI ## Database ID URL or Descriptions # AltName CSE1_ECOLI CRISPR type I-E/Ecoli-associated protein CasA/Cse1 # AltName CSE1_ECOLI CRISPR-associated protein CasA/Cse1 # BioGrid 4260748 358 # CDD cd09669 Cse1_I-E # DISRUPTION PHENOTYPE CSE1_ECOLI Loss of resistance to bacteriophage lambda infection, loss of plasmid silencing. {ECO 0000269|PubMed 18703739, ECO 0000269|PubMed 21255106, ECO 0000269|PubMed 21460843}. # EcoGene EG13119 casA # FUNCTION CSE1_ECOLI A component of Cascade, which participates in CRISPR interference, the third stage of CRISPR immunity. Cascade binds both crRNA and in a sequence-specific manner negatively supercoiled dsDNA target. This leads to the formation of an R-loop in which the crRNA binds the target DNA, displacing the noncomplementary strand. Cas3 is recruited to Cascade, probably via interactions with CasA, nicks target DNA and then unwinds and cleaves the target, leading to DNA degradation and invader neutralization. CasA is not required for formation of Cascade, but probably enhances binding to and subsequent recognition of both target dsDNA and ssDNA. # FUNCTION CSE1_ECOLI CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). # GO_component GO:0043234 protein complex; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0003723 RNA binding; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_process GO:0051607 defense response to virus; IMP:EcoCyc. # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0002376 immune system process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0044403 symbiosis, encompassing mutualism through parasitism # INDUCTION CSE1_ECOLI Repressed by H-NS, activated by LeuO. Activated by the BaeSR two-component regulatory system, possibly due to envelope stress. Part of the casABCDE-ygbT-ygbF operon. {ECO 0000269|PubMed 19429622, ECO 0000269|PubMed 20132443, ECO 0000269|PubMed 20659289, ECO 0000269|PubMed 21255106}. # IntAct Q46901 6 # InterPro IPR013381 CRISPR-assoc_prot_Cse1 # MASS SPECTROMETRY Mass=55972.4; Mass_error=14.8; Method=Unknown; Range=1-502; Evidence={ECO:0000269|PubMed 21460843}; # Organism CSE1_ECOLI Escherichia coli (strain K12) # PATRIC 32120930 VBIEscCol129921_2857 # PDB 4QYZ X-ray; 3.03 A; A=1-502 # PDB 4TVX X-ray; 3.24 A; I/U=1-502 # PDB 4U7U X-ray; 3.00 A; A/M=1-502 # PDB 5CD4 X-ray; 3.20 A; I/U=1-502 # PDB 5H9E X-ray; 3.21 A; A=1-502 # PDB 5H9F X-ray; 2.45 A; A=1-502 # PIR D65057 D65057 # Pfam PF09481 CRISPR_Cse1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CSE1_ECOLI CRISPR system Cascade subunit CasA # RefSeq NP_417240 NC_000913.3 # RefSeq WP_001050401 NZ_LN832404.1 # SIMILARITY Belongs to the CRISPR associated protein CasA/Cse1 family. Type I-E/Ecoli subfamily. {ECO 0000305}. # SUBUNIT CSE1_ECOLI Part of the Cascade ribonucleoprotein complex, with stoichiometry CasA(1),CasB(2),CasC(6),CasD(1),CasE(1)-crRNA(1). Interacts directly with the 5' end of crRNA, CasB, CasD and CasE. Binding of target ssRNA or dsDNA causes a conformational change in the Cascade complex; CasA is required for high affinity target DNA binding. Interacts with Cas3 once Cascade has recognized target DNA. {ECO 0000269|PubMed 18703739, ECO 0000269|PubMed 21255106, ECO 0000269|PubMed 21460843, ECO 0000269|PubMed 21938068, ECO 0000269|PubMed 22521689}. # TIGRFAMs TIGR02547 casA_cse1 # eggNOG ENOG4105CYR Bacteria # eggNOG ENOG410XPCD LUCA BLAST swissprot:CSE1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CSE1_ECOLI BioCyc ECOL316407:JW2730-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2730-MONOMER BioCyc EcoCyc:G7430-MONOMER http://biocyc.org/getid?id=EcoCyc:G7430-MONOMER BioCyc MetaCyc:G7430-MONOMER http://biocyc.org/getid?id=MetaCyc:G7430-MONOMER DIP DIP-12128N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12128N DOI 10.1016/j.molcel.2012.03.018 http://dx.doi.org/10.1016/j.molcel.2012.03.018 DOI 10.1016/j.molcel.2012.03.020 http://dx.doi.org/10.1016/j.molcel.2012.03.020 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature10402 http://dx.doi.org/10.1038/nature10402 DOI 10.1038/nsmb.2019 http://dx.doi.org/10.1038/nsmb.2019 DOI 10.1074/jbc.C112.379503 http://dx.doi.org/10.1074/jbc.C112.379503 DOI 10.1111/j.1365-2958.2010.07073.x http://dx.doi.org/10.1111/j.1365-2958.2010.07073.x DOI 10.1111/j.1365-2958.2010.07315.x http://dx.doi.org/10.1111/j.1365-2958.2010.07315.x DOI 10.1111/j.1365-2958.2010.07482.x http://dx.doi.org/10.1111/j.1365-2958.2010.07482.x DOI 10.1126/science.1159689 http://dx.doi.org/10.1126/science.1159689 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00108-09 http://dx.doi.org/10.1128/JB.00108-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EchoBASE EB2920 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2920 EcoGene EG13119 http://www.ecogene.org/geneInfo.php?eg_id=EG13119 EnsemblBacteria AAC75802 http://www.ensemblgenomes.org/id/AAC75802 EnsemblBacteria AAC75802 http://www.ensemblgenomes.org/id/AAC75802 EnsemblBacteria BAE76837 http://www.ensemblgenomes.org/id/BAE76837 EnsemblBacteria BAE76837 http://www.ensemblgenomes.org/id/BAE76837 EnsemblBacteria BAE76837 http://www.ensemblgenomes.org/id/BAE76837 EnsemblBacteria b2760 http://www.ensemblgenomes.org/id/b2760 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_process GO:0051607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051607 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0002376 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0044403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403 GeneID 947222 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947222 HOGENOM HOG000009770 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009770&db=HOGENOM6 InParanoid Q46901 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46901 IntAct Q46901 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46901* InterPro IPR013381 http://www.ebi.ac.uk/interpro/entry/IPR013381 KEGG_Gene ecj:JW2730 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2730 KEGG_Gene eco:b2760 http://www.genome.jp/dbget-bin/www_bget?eco:b2760 OMA TPITTFV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TPITTFV PDB 4QYZ http://www.ebi.ac.uk/pdbe-srv/view/entry/4QYZ PDB 4TVX http://www.ebi.ac.uk/pdbe-srv/view/entry/4TVX PDB 4U7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U7U PDB 5CD4 http://www.ebi.ac.uk/pdbe-srv/view/entry/5CD4 PDB 5H9E http://www.ebi.ac.uk/pdbe-srv/view/entry/5H9E PDB 5H9F http://www.ebi.ac.uk/pdbe-srv/view/entry/5H9F PDBsum 4QYZ http://www.ebi.ac.uk/pdbsum/4QYZ PDBsum 4TVX http://www.ebi.ac.uk/pdbsum/4TVX PDBsum 4U7U http://www.ebi.ac.uk/pdbsum/4U7U PDBsum 5CD4 http://www.ebi.ac.uk/pdbsum/5CD4 PDBsum 5H9E http://www.ebi.ac.uk/pdbsum/5H9E PDBsum 5H9F http://www.ebi.ac.uk/pdbsum/5H9F PSORT swissprot:CSE1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CSE1_ECOLI PSORT-B swissprot:CSE1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CSE1_ECOLI PSORT2 swissprot:CSE1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CSE1_ECOLI Pfam PF09481 http://pfam.xfam.org/family/PF09481 Phobius swissprot:CSE1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CSE1_ECOLI ProteinModelPortal Q46901 http://www.proteinmodelportal.org/query/uniprot/Q46901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18703739 http://www.ncbi.nlm.nih.gov/pubmed/18703739 PubMed 19429622 http://www.ncbi.nlm.nih.gov/pubmed/19429622 PubMed 20132443 http://www.ncbi.nlm.nih.gov/pubmed/20132443 PubMed 20659289 http://www.ncbi.nlm.nih.gov/pubmed/20659289 PubMed 21255106 http://www.ncbi.nlm.nih.gov/pubmed/21255106 PubMed 21460843 http://www.ncbi.nlm.nih.gov/pubmed/21460843 PubMed 21938068 http://www.ncbi.nlm.nih.gov/pubmed/21938068 PubMed 22521689 http://www.ncbi.nlm.nih.gov/pubmed/22521689 PubMed 22521690 http://www.ncbi.nlm.nih.gov/pubmed/22521690 PubMed 22621933 http://www.ncbi.nlm.nih.gov/pubmed/22621933 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417240 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417240 RefSeq WP_001050401 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001050401 SMR Q46901 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46901 STRING 511145.b2760 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2760&targetmode=cogs TIGRFAMs TIGR02547 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02547 UniProtKB CSE1_ECOLI http://www.uniprot.org/uniprot/CSE1_ECOLI UniProtKB-AC Q46901 http://www.uniprot.org/uniprot/Q46901 charge swissprot:CSE1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CSE1_ECOLI eggNOG ENOG4105CYR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CYR eggNOG ENOG410XPCD http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPCD epestfind swissprot:CSE1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CSE1_ECOLI garnier swissprot:CSE1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CSE1_ECOLI helixturnhelix swissprot:CSE1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CSE1_ECOLI hmoment swissprot:CSE1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CSE1_ECOLI iep swissprot:CSE1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CSE1_ECOLI inforesidue swissprot:CSE1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CSE1_ECOLI octanol swissprot:CSE1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CSE1_ECOLI pepcoil swissprot:CSE1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CSE1_ECOLI pepdigest swissprot:CSE1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CSE1_ECOLI pepinfo swissprot:CSE1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CSE1_ECOLI pepnet swissprot:CSE1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CSE1_ECOLI pepstats swissprot:CSE1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CSE1_ECOLI pepwheel swissprot:CSE1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CSE1_ECOLI pepwindow swissprot:CSE1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CSE1_ECOLI sigcleave swissprot:CSE1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CSE1_ECOLI ## Database ID URL or Descriptions # BioGrid 4261972 8 # EcoGene EG11951 yjcO # GO_function GO:0008047 enzyme activator activity; IBA:GO_Central. # GOslim_function GO:0030234 enzyme regulator activity # Gene3D 1.25.40.10 -; 1. # InterPro IPR006597 Sel1-like # InterPro IPR011990 TPR-like_helical_dom # Organism YJCO_ECOLI Escherichia coli (strain K12) # PATRIC 32123707 VBIEscCol129921_4202 # PIR E65216 E65216 # Pfam PF08238 Sel1; 4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJCO_ECOLI Uncharacterized protein YjcO # RefSeq NP_418502 NC_000913.3 # RefSeq WP_000719886 NZ_LN832404.1 # SMART SM00671 SEL1; 4 # eggNOG COG0790 LUCA # eggNOG ENOG41082ND Bacteria BLAST swissprot:YJCO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJCO_ECOLI BioCyc ECOL316407:JW4039-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4039-MONOMER BioCyc EcoCyc:EG11951-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11951-MONOMER COG COG0790 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0790 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1894 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1894 EcoGene EG11951 http://www.ecogene.org/geneInfo.php?eg_id=EG11951 EnsemblBacteria AAD13461 http://www.ensemblgenomes.org/id/AAD13461 EnsemblBacteria AAD13461 http://www.ensemblgenomes.org/id/AAD13461 EnsemblBacteria BAE78080 http://www.ensemblgenomes.org/id/BAE78080 EnsemblBacteria BAE78080 http://www.ensemblgenomes.org/id/BAE78080 EnsemblBacteria BAE78080 http://www.ensemblgenomes.org/id/BAE78080 EnsemblBacteria b4078 http://www.ensemblgenomes.org/id/b4078 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008047 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008047 GOslim_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 Gene3D 1.25.40.10 http://www.cathdb.info/version/latest/superfamily/1.25.40.10 GeneID 948586 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948586 HOGENOM HOG000126942 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126942&db=HOGENOM6 InParanoid P0AF56 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AF56 InterPro IPR006597 http://www.ebi.ac.uk/interpro/entry/IPR006597 InterPro IPR011990 http://www.ebi.ac.uk/interpro/entry/IPR011990 KEGG_Gene ecj:JW4039 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4039 KEGG_Gene eco:b4078 http://www.genome.jp/dbget-bin/www_bget?eco:b4078 KEGG_Orthology KO:K07126 http://www.genome.jp/dbget-bin/www_bget?KO:K07126 OMA PKNDARA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PKNDARA PSORT swissprot:YJCO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJCO_ECOLI PSORT-B swissprot:YJCO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJCO_ECOLI PSORT2 swissprot:YJCO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJCO_ECOLI Pfam PF08238 http://pfam.xfam.org/family/PF08238 Phobius swissprot:YJCO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJCO_ECOLI PhylomeDB P0AF56 http://phylomedb.org/?seqid=P0AF56 ProteinModelPortal P0AF56 http://www.proteinmodelportal.org/query/uniprot/P0AF56 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418502 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418502 RefSeq WP_000719886 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000719886 SMART SM00671 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00671 SMR P0AF56 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AF56 STRING 511145.b4078 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4078&targetmode=cogs STRING COG0790 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0790&targetmode=cogs UniProtKB YJCO_ECOLI http://www.uniprot.org/uniprot/YJCO_ECOLI UniProtKB-AC P0AF56 http://www.uniprot.org/uniprot/P0AF56 charge swissprot:YJCO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJCO_ECOLI eggNOG COG0790 http://eggnogapi.embl.de/nog_data/html/tree/COG0790 eggNOG ENOG41082ND http://eggnogapi.embl.de/nog_data/html/tree/ENOG41082ND epestfind swissprot:YJCO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJCO_ECOLI garnier swissprot:YJCO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJCO_ECOLI helixturnhelix swissprot:YJCO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJCO_ECOLI hmoment swissprot:YJCO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJCO_ECOLI iep swissprot:YJCO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJCO_ECOLI inforesidue swissprot:YJCO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJCO_ECOLI octanol swissprot:YJCO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJCO_ECOLI pepcoil swissprot:YJCO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJCO_ECOLI pepdigest swissprot:YJCO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJCO_ECOLI pepinfo swissprot:YJCO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJCO_ECOLI pepnet swissprot:YJCO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJCO_ECOLI pepstats swissprot:YJCO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJCO_ECOLI pepwheel swissprot:YJCO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJCO_ECOLI pepwindow swissprot:YJCO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJCO_ECOLI sigcleave swissprot:YJCO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJCO_ECOLI ## Database ID URL or Descriptions # BioGrid 4259583 16 # EcoGene EG11144 yfcA # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0009408 response to heat; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006950 response to stress # IntAct P0AD30 2 # InterPro IPR002781 TM_pro_TauE-like # Organism YFCA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30269 PTHR30269 # PATRIC 32120027 VBIEscCol129921_2423 # PIR S08346 S08346 # Pfam PF01925 TauE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFCA_ECOLI UPF0721 transmembrane protein YfcA # RefSeq NP_416830 NC_000913.3 # RefSeq WP_000447361 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0721 family. {ECO 0000305}. # SUBCELLULAR LOCATION YFCA_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.102.3 the 4-toluene sulfonate uptake permease (tsup) family # eggNOG COG0730 LUCA # eggNOG ENOG4105EJ9 Bacteria BLAST swissprot:YFCA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFCA_ECOLI BioCyc ECOL316407:JW2324-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2324-MONOMER BioCyc EcoCyc:EG11144-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11144-MONOMER COG COG0730 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0730 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1365-2958.1990.tb00588.x http://dx.doi.org/10.1111/j.1365-2958.1990.tb00588.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X16909 http://www.ebi.ac.uk/ena/data/view/X16909 EchoBASE EB1134 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1134 EcoGene EG11144 http://www.ecogene.org/geneInfo.php?eg_id=EG11144 EnsemblBacteria AAC75387 http://www.ensemblgenomes.org/id/AAC75387 EnsemblBacteria AAC75387 http://www.ensemblgenomes.org/id/AAC75387 EnsemblBacteria BAA16183 http://www.ensemblgenomes.org/id/BAA16183 EnsemblBacteria BAA16183 http://www.ensemblgenomes.org/id/BAA16183 EnsemblBacteria BAA16183 http://www.ensemblgenomes.org/id/BAA16183 EnsemblBacteria b2327 http://www.ensemblgenomes.org/id/b2327 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 946808 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946808 HOGENOM HOG000114880 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000114880&db=HOGENOM6 InParanoid P0AD30 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AD30 IntAct P0AD30 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AD30* InterPro IPR002781 http://www.ebi.ac.uk/interpro/entry/IPR002781 KEGG_Gene ecj:JW2324 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2324 KEGG_Gene eco:b2327 http://www.genome.jp/dbget-bin/www_bget?eco:b2327 KEGG_Orthology KO:K07090 http://www.genome.jp/dbget-bin/www_bget?KO:K07090 OMA GTNKGQS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GTNKGQS PANTHER PTHR30269 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30269 PSORT swissprot:YFCA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFCA_ECOLI PSORT-B swissprot:YFCA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFCA_ECOLI PSORT2 swissprot:YFCA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFCA_ECOLI Pfam PF01925 http://pfam.xfam.org/family/PF01925 Phobius swissprot:YFCA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFCA_ECOLI PhylomeDB P0AD30 http://phylomedb.org/?seqid=P0AD30 ProteinModelPortal P0AD30 http://www.proteinmodelportal.org/query/uniprot/P0AD30 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2187143 http://www.ncbi.nlm.nih.gov/pubmed/2187143 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416830 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416830 RefSeq WP_000447361 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000447361 STRING 511145.b2327 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2327&targetmode=cogs STRING COG0730 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0730&targetmode=cogs TCDB 2.A.102.3 http://www.tcdb.org/search/result.php?tc=2.A.102.3 UniProtKB YFCA_ECOLI http://www.uniprot.org/uniprot/YFCA_ECOLI UniProtKB-AC P0AD30 http://www.uniprot.org/uniprot/P0AD30 charge swissprot:YFCA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFCA_ECOLI eggNOG COG0730 http://eggnogapi.embl.de/nog_data/html/tree/COG0730 eggNOG ENOG4105EJ9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EJ9 epestfind swissprot:YFCA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFCA_ECOLI garnier swissprot:YFCA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFCA_ECOLI helixturnhelix swissprot:YFCA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFCA_ECOLI hmoment swissprot:YFCA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFCA_ECOLI iep swissprot:YFCA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFCA_ECOLI inforesidue swissprot:YFCA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFCA_ECOLI octanol swissprot:YFCA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFCA_ECOLI pepcoil swissprot:YFCA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFCA_ECOLI pepdigest swissprot:YFCA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFCA_ECOLI pepinfo swissprot:YFCA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFCA_ECOLI pepnet swissprot:YFCA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFCA_ECOLI pepstats swissprot:YFCA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFCA_ECOLI pepwheel swissprot:YFCA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFCA_ECOLI pepwindow swissprot:YFCA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFCA_ECOLI sigcleave swissprot:YFCA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFCA_ECOLI ## Database ID URL or Descriptions # AltName RHAM_ECOLI Rhamnose 1-epimerase # AltName RHAM_ECOLI Type-3 mutarotase # BRENDA 5.1.3.32 2026 # BioGrid 4262642 28 # CATALYTIC ACTIVITY RHAM_ECOLI Alpha-L-rhamnopyranose = beta-L- rhamnopyranose. {ECO 0000269|PubMed 15060078, ECO 0000269|PubMed 15876375}. # EcoGene EG11865 rhaM # FUNCTION RHAM_ECOLI Involved in the anomeric conversion of L-rhamnose. {ECO 0000269|PubMed 15060078}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives; IDA:EcoCyc. # GO_process GO:0019301 rhamnose catabolic process; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # HAMAP MF_01663 L_rham_rotase # IntAct P32156 2 # InterPro IPR008000 Rham/fucose_mutarotase # InterPro IPR011008 Dimeric_a/b-barrel # InterPro IPR013448 L-rhamnose_mutarotase_rhaM # KEGG_Brite ko01000 Enzymes # Organism RHAM_ECOLI Escherichia coli (strain K12) # PATHWAY RHAM_ECOLI Carbohydrate metabolism; L-rhamnose metabolism. # PATRIC 32123311 VBIEscCol129921_4016 # PDB 1X8D X-ray; 1.80 A; A/B/C/D=1-104 # PIR S40845 S40845 # Pfam PF05336 rhaM # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RHAM_ECOLI L-rhamnose mutarotase # RefSeq NP_418337 NC_000913.3 # RefSeq WP_000619493 NZ_LN832404.1 # SIMILARITY Belongs to the rhamnose mutarotase family. {ECO 0000305}. # SUBCELLULAR LOCATION RHAM_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 15876375}. # SUPFAM SSF54909 SSF54909 # TIGRFAMs TIGR02625 YiiL_rotase # eggNOG COG3254 LUCA # eggNOG ENOG4105M10 Bacteria BLAST swissprot:RHAM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RHAM_ECOLI BioCyc ECOL316407:JW3872-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3872-MONOMER BioCyc EcoCyc:EG11865-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11865-MONOMER BioCyc MetaCyc:EG11865-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11865-MONOMER COG COG3254 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3254 DOI 10.1016/j.jmb.2005.03.047 http://dx.doi.org/10.1016/j.jmb.2005.03.047 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M402016200 http://dx.doi.org/10.1074/jbc.M402016200 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.1.3.32 {ECO:0000269|PubMed:15060078, ECO:0000269|PubMed:15876375} http://www.genome.jp/dbget-bin/www_bget?EC:5.1.3.32 {ECO:0000269|PubMed:15060078, ECO:0000269|PubMed:15876375} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 5.1.3.32 {ECO:0000269|PubMed:15060078, ECO:0000269|PubMed:15876375} http://enzyme.expasy.org/EC/5.1.3.32 {ECO:0000269|PubMed:15060078, ECO:0000269|PubMed:15876375} EchoBASE EB1811 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1811 EcoGene EG11865 http://www.ecogene.org/geneInfo.php?eg_id=EG11865 EnsemblBacteria AAC76883 http://www.ensemblgenomes.org/id/AAC76883 EnsemblBacteria AAC76883 http://www.ensemblgenomes.org/id/AAC76883 EnsemblBacteria BAE77408 http://www.ensemblgenomes.org/id/BAE77408 EnsemblBacteria BAE77408 http://www.ensemblgenomes.org/id/BAE77408 EnsemblBacteria BAE77408 http://www.ensemblgenomes.org/id/BAE77408 EnsemblBacteria b3901 http://www.ensemblgenomes.org/id/b3901 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0016857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016857 GO_process GO:0019301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019301 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 948402 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948402 HAMAP MF_01663 http://hamap.expasy.org/unirule/MF_01663 HOGENOM HOG000250144 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000250144&db=HOGENOM6 InParanoid P32156 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32156 IntAct P32156 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32156* IntEnz 5.1.3.32 {ECO:0000269|PubMed:15060078, ECO:0000269|PubMed:15876375} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.1.3.32 {ECO:0000269|PubMed:15060078, ECO:0000269|PubMed:15876375} InterPro IPR008000 http://www.ebi.ac.uk/interpro/entry/IPR008000 InterPro IPR011008 http://www.ebi.ac.uk/interpro/entry/IPR011008 InterPro IPR013448 http://www.ebi.ac.uk/interpro/entry/IPR013448 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3872 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3872 KEGG_Gene eco:b3901 http://www.genome.jp/dbget-bin/www_bget?eco:b3901 KEGG_Orthology KO:K03534 http://www.genome.jp/dbget-bin/www_bget?KO:K03534 OMA KRHDEIW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KRHDEIW PDB 1X8D http://www.ebi.ac.uk/pdbe-srv/view/entry/1X8D PDBsum 1X8D http://www.ebi.ac.uk/pdbsum/1X8D PSORT swissprot:RHAM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RHAM_ECOLI PSORT-B swissprot:RHAM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RHAM_ECOLI PSORT2 swissprot:RHAM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RHAM_ECOLI Pfam PF05336 http://pfam.xfam.org/family/PF05336 Phobius swissprot:RHAM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RHAM_ECOLI PhylomeDB P32156 http://phylomedb.org/?seqid=P32156 ProteinModelPortal P32156 http://www.proteinmodelportal.org/query/uniprot/P32156 PubMed 15060078 http://www.ncbi.nlm.nih.gov/pubmed/15060078 PubMed 15876375 http://www.ncbi.nlm.nih.gov/pubmed/15876375 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418337 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418337 RefSeq WP_000619493 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000619493 SMR P32156 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32156 STRING 511145.b3901 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3901&targetmode=cogs STRING COG3254 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3254&targetmode=cogs SUPFAM SSF54909 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54909 TIGRFAMs TIGR02625 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02625 UniProtKB RHAM_ECOLI http://www.uniprot.org/uniprot/RHAM_ECOLI UniProtKB-AC P32156 http://www.uniprot.org/uniprot/P32156 charge swissprot:RHAM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RHAM_ECOLI eggNOG COG3254 http://eggnogapi.embl.de/nog_data/html/tree/COG3254 eggNOG ENOG4105M10 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105M10 epestfind swissprot:RHAM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RHAM_ECOLI garnier swissprot:RHAM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RHAM_ECOLI helixturnhelix swissprot:RHAM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RHAM_ECOLI hmoment swissprot:RHAM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RHAM_ECOLI iep swissprot:RHAM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RHAM_ECOLI inforesidue swissprot:RHAM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RHAM_ECOLI octanol swissprot:RHAM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RHAM_ECOLI pepcoil swissprot:RHAM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RHAM_ECOLI pepdigest swissprot:RHAM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RHAM_ECOLI pepinfo swissprot:RHAM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RHAM_ECOLI pepnet swissprot:RHAM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RHAM_ECOLI pepstats swissprot:RHAM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RHAM_ECOLI pepwheel swissprot:RHAM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RHAM_ECOLI pepwindow swissprot:RHAM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RHAM_ECOLI sigcleave swissprot:RHAM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RHAM_ECOLI ## Database ID URL or Descriptions # BioGrid 4261267 6 # CDD cd00383 trans_reg_C # EcoGene EG10672 ompR # FUNCTION OMPR_ECOLI The N-terminus of this protein is required for the transcriptional expression of both major outer membrane protein genes ompF and ompC; its C-terminal moiety mediates the multimerization of the OmpR protein. As a multimer, it turns on the expression of the ompC gene; as a monomer, it turns on the expression of the ompF gene. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0000156 phosphorelay response regulator activity; IDA:EcoliWiki. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0000160 phosphorelay signal transduction system; IDA:EcoliWiki. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IDA:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004871 signal transducer activity # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # IntAct P0AA16 10 # InterPro IPR001789 Sig_transdc_resp-reg_receiver # InterPro IPR001867 OmpR/PhoB-type_DNA-bd # InterPro IPR011006 CheY-like_superfamily # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR016032 Sig_transdc_resp-reg_C-effctor # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02022 M00445 EnvZ-OmpR (osmotic stress response) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # Organism OMPR_ECOLI Escherichia coli (strain K12) # PATRIC 32122246 VBIEscCol129921_3500 # PDB 1ODD X-ray; 2.20 A; A=122-239 # PDB 1OPC X-ray; 1.95 A; A=130-239 # PDB 2JPB NMR; -; A=136-239 # PIR H65135 RGECOR # PROSITE PS50110 RESPONSE_REGULATORY # PROSITE PS51755 OMPR_PHOB # PTM OMPR_ECOLI Phosphorylated by EnvZ. Asp-55 is the primary phosphate acceptor site, but Asp-11 may also serve as a phosphorylation site, particularly in the absence of Asp-55. {ECO 0000269|PubMed 7934854}. # Pfam PF00072 Response_reg # Pfam PF00486 Trans_reg_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName OMPR_ECOLI Transcriptional regulatory protein OmpR # RefSeq NP_417864 NC_000913.3 # RefSeq WP_001157751 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=Ref.1; Type=Frameshift; Positions=210; Evidence={ECO 0000305}; # SIMILARITY Contains 1 OmpR/PhoB-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU01091}. # SIMILARITY Contains 1 response regulatory domain. {ECO:0000255|PROSITE-ProRule PRU00169}. # SMART SM00448 REC # SMART SM00862 Trans_reg_C # SUBCELLULAR LOCATION OMPR_ECOLI Cytoplasm. # SUBUNIT OMPR_ECOLI Monomer and multimer. # SUPFAM SSF46894 SSF46894 # SUPFAM SSF52172 SSF52172 BLAST swissprot:OMPR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:OMPR_ECOLI BioCyc ECOL316407:JW3368-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3368-MONOMER BioCyc EcoCyc:OMPR-MONOMER http://biocyc.org/getid?id=EcoCyc:OMPR-MONOMER COG COG0745 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0745 DIP DIP-31859N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31859N DOI 10.1007/BF00331636 http://dx.doi.org/10.1007/BF00331636 DOI 10.1016/S0969-2126(97)00170-6 http://dx.doi.org/10.1016/S0969-2126(97)00170-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb0197-28 http://dx.doi.org/10.1038/nsb0197-28 DOI 10.1111/j.1365-2958.1993.tb00974.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb00974.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01656 http://www.ebi.ac.uk/ena/data/view/J01656 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB0666 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0666 EcoGene EG10672 http://www.ecogene.org/geneInfo.php?eg_id=EG10672 EnsemblBacteria AAC76430 http://www.ensemblgenomes.org/id/AAC76430 EnsemblBacteria AAC76430 http://www.ensemblgenomes.org/id/AAC76430 EnsemblBacteria BAE77886 http://www.ensemblgenomes.org/id/BAE77886 EnsemblBacteria BAE77886 http://www.ensemblgenomes.org/id/BAE77886 EnsemblBacteria BAE77886 http://www.ensemblgenomes.org/id/BAE77886 EnsemblBacteria b3405 http://www.ensemblgenomes.org/id/b3405 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000156 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000156 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 8912757 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8912757 GeneID 947913 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947913 HOGENOM HOG000034819 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000034819&db=HOGENOM6 InParanoid P0AA16 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AA16 IntAct P0AA16 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AA16* InterPro IPR001789 http://www.ebi.ac.uk/interpro/entry/IPR001789 InterPro IPR001867 http://www.ebi.ac.uk/interpro/entry/IPR001867 InterPro IPR011006 http://www.ebi.ac.uk/interpro/entry/IPR011006 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR016032 http://www.ebi.ac.uk/interpro/entry/IPR016032 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW3368 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3368 KEGG_Gene eco:b3405 http://www.genome.jp/dbget-bin/www_bget?eco:b3405 KEGG_Orthology KO:K07659 http://www.genome.jp/dbget-bin/www_bget?KO:K07659 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA MDVERHI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MDVERHI PDB 1ODD http://www.ebi.ac.uk/pdbe-srv/view/entry/1ODD PDB 1OPC http://www.ebi.ac.uk/pdbe-srv/view/entry/1OPC PDB 2JPB http://www.ebi.ac.uk/pdbe-srv/view/entry/2JPB PDBsum 1ODD http://www.ebi.ac.uk/pdbsum/1ODD PDBsum 1OPC http://www.ebi.ac.uk/pdbsum/1OPC PDBsum 2JPB http://www.ebi.ac.uk/pdbsum/2JPB PROSITE PS50110 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50110 PROSITE PS51755 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51755 PSORT swissprot:OMPR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:OMPR_ECOLI PSORT-B swissprot:OMPR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:OMPR_ECOLI PSORT2 swissprot:OMPR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:OMPR_ECOLI Pfam PF00072 http://pfam.xfam.org/family/PF00072 Pfam PF00486 http://pfam.xfam.org/family/PF00486 Phobius swissprot:OMPR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:OMPR_ECOLI PhylomeDB P0AA16 http://phylomedb.org/?seqid=P0AA16 ProteinModelPortal P0AA16 http://www.proteinmodelportal.org/query/uniprot/P0AA16 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2997120 http://www.ncbi.nlm.nih.gov/pubmed/2997120 PubMed 3010044 http://www.ncbi.nlm.nih.gov/pubmed/3010044 PubMed 6292199 http://www.ncbi.nlm.nih.gov/pubmed/6292199 PubMed 7934854 http://www.ncbi.nlm.nih.gov/pubmed/7934854 PubMed 8989318 http://www.ncbi.nlm.nih.gov/pubmed/8989318 PubMed 9016718 http://www.ncbi.nlm.nih.gov/pubmed/9016718 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417864 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417864 RefSeq WP_001157751 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001157751 SMART SM00448 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00448 SMART SM00862 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00862 SMR P0AA16 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AA16 STRING 511145.b3405 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3405&targetmode=cogs STRING COG0745 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0745&targetmode=cogs SUPFAM SSF46894 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46894 SUPFAM SSF52172 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52172 UniProtKB OMPR_ECOLI http://www.uniprot.org/uniprot/OMPR_ECOLI UniProtKB-AC P0AA16 http://www.uniprot.org/uniprot/P0AA16 charge swissprot:OMPR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:OMPR_ECOLI epestfind swissprot:OMPR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:OMPR_ECOLI garnier swissprot:OMPR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:OMPR_ECOLI helixturnhelix swissprot:OMPR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:OMPR_ECOLI hmoment swissprot:OMPR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:OMPR_ECOLI iep swissprot:OMPR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:OMPR_ECOLI inforesidue swissprot:OMPR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:OMPR_ECOLI octanol swissprot:OMPR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:OMPR_ECOLI pepcoil swissprot:OMPR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:OMPR_ECOLI pepdigest swissprot:OMPR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:OMPR_ECOLI pepinfo swissprot:OMPR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:OMPR_ECOLI pepnet swissprot:OMPR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:OMPR_ECOLI pepstats swissprot:OMPR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:OMPR_ECOLI pepwheel swissprot:OMPR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:OMPR_ECOLI pepwindow swissprot:OMPR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:OMPR_ECOLI sigcleave swissprot:OMPR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:OMPR_ECOLI ## Database ID URL or Descriptions # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG14081 yfaS # GO_function GO:0004866 endopeptidase inhibitor activity; IEA:InterPro. # GOslim_function GO:0030234 enzyme regulator activity # IntAct P76464 25 # InterPro IPR001599 Macroglobln_a2 # InterPro IPR002890 A2M_N # InterPro IPR008930 Terpenoid_cyclase/PrenylTrfase # InterPro IPR011625 A2M_N_2 # Organism YFAS_ECOLI Escherichia coli (strain K12) # Pfam PF00207 A2M # Pfam PF01835 A2M_N # Pfam PF07703 A2M_N_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFAS_ECOLI Putative UPF0192 protein YfaS # SEQUENCE CAUTION Sequence=AP009048; Type=Erroneous termination; Positions=1368; Note=Translated as Trp.; Evidence={ECO:0000305}; Sequence=U00096; Type=Erroneous termination; Positions=1368; Note=Translated as Trp.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the UPF0192 family. {ECO 0000305}. # SMART SM01359 A2M_N_2 # SMART SM01360 A2M # SUPFAM SSF48239 SSF48239 BLAST swissprot:YFAS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFAS_ECOLI BioCyc EcoCyc:G7154-MONOMER http://biocyc.org/getid?id=EcoCyc:G7154-MONOMER BioCyc EcoCyc:G7155-MONOMER http://biocyc.org/getid?id=EcoCyc:G7155-MONOMER DIP DIP-11951N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11951N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3834 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3834 EcoGene EG14081 http://www.ecogene.org/geneInfo.php?eg_id=EG14081 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004866 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004866 GOslim_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 HOGENOM HOG000122345 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122345&db=HOGENOM6 InParanoid P76464 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76464 IntAct P76464 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76464* InterPro IPR001599 http://www.ebi.ac.uk/interpro/entry/IPR001599 InterPro IPR002890 http://www.ebi.ac.uk/interpro/entry/IPR002890 InterPro IPR008930 http://www.ebi.ac.uk/interpro/entry/IPR008930 InterPro IPR011625 http://www.ebi.ac.uk/interpro/entry/IPR011625 PSORT swissprot:YFAS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFAS_ECOLI PSORT-B swissprot:YFAS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFAS_ECOLI PSORT2 swissprot:YFAS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFAS_ECOLI Pfam PF00207 http://pfam.xfam.org/family/PF00207 Pfam PF01835 http://pfam.xfam.org/family/PF01835 Pfam PF07703 http://pfam.xfam.org/family/PF07703 Phobius swissprot:YFAS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFAS_ECOLI PhylomeDB P76464 http://phylomedb.org/?seqid=P76464 ProteinModelPortal P76464 http://www.proteinmodelportal.org/query/uniprot/P76464 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SMART SM01359 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01359 SMART SM01360 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01360 SUPFAM SSF48239 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48239 UniProtKB YFAS_ECOLI http://www.uniprot.org/uniprot/YFAS_ECOLI UniProtKB-AC P76464 http://www.uniprot.org/uniprot/P76464 charge swissprot:YFAS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFAS_ECOLI epestfind swissprot:YFAS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFAS_ECOLI garnier swissprot:YFAS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFAS_ECOLI helixturnhelix swissprot:YFAS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFAS_ECOLI hmoment swissprot:YFAS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFAS_ECOLI iep swissprot:YFAS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFAS_ECOLI inforesidue swissprot:YFAS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFAS_ECOLI octanol swissprot:YFAS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFAS_ECOLI pepcoil swissprot:YFAS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFAS_ECOLI pepdigest swissprot:YFAS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFAS_ECOLI pepinfo swissprot:YFAS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFAS_ECOLI pepnet swissprot:YFAS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFAS_ECOLI pepstats swissprot:YFAS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFAS_ECOLI pepwheel swissprot:YFAS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFAS_ECOLI pepwindow swissprot:YFAS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFAS_ECOLI sigcleave swissprot:YFAS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFAS_ECOLI ## Database ID URL or Descriptions # AltName FTSI_ECOLI Penicillin-binding protein 3 {ECO 0000303|PubMed 1103132, ECO 0000303|PubMed 7030331} # AltName Peptidoglycan glycosyltransferase 3 {ECO 0000305} # BioGrid 4261637 81 # CATALYTIC ACTIVITY (GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L- Lys-D-Ala-D-Ala))(n)-diphosphoundecaprenol + GlcNAc-(1->4)- Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)- diphosphoundecaprenol = (GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D- Glu-L-Lys-D-Ala-D-Ala))(n+1)-diphosphoundecaprenol + undecaprenyl diphosphate. {ECO:0000269|PubMed 7030331}. # DOMAIN FTSI_ECOLI Contains an N-terminal membrane anchor-containing module, a central non-catalytic domain and a C-terminal penicillin-binding (PB) catalytic domain. The transmembrane region is essential for localization to the septal ring, interaction with FtsW and cell septation. {ECO 0000269|PubMed 14702319, ECO 0000269|PubMed 15601716, ECO 0000269|PubMed 20847002, ECO 0000269|PubMed 9614966}. # DrugBank DB00267 Cefmenoxime # DrugBank DB00274 Cefmetazole # DrugBank DB00303 Ertapenem # DrugBank DB00430 Cefpiramide # DrugBank DB00438 Ceftazidime # DrugBank DB01327 Cefazolin # DrugBank DB01328 Cefonicid # DrugBank DB01329 Cefoperazone # DrugBank DB01331 Cefoxitin # DrugBank DB01332 Ceftizoxime # DrugBank DB01413 Cefepime # DrugBank DB01415 Ceftibuten # DrugBank DB01416 Cefpodoxime # ENZYME REGULATION FTSI_ECOLI Inhibited by beta-lactam antibiotics such as penicillin, moenomycin and macarbomycin. Antibiotics inhibit the activity by binding to the catalytic serine. {ECO 0000269|PubMed 3900044, ECO 0000269|PubMed 7030331}. # EcoGene EG10341 ftsI # FUNCTION FTSI_ECOLI Essential cell division protein that is required for the synthesis of peptidoglycan at the division septum (PubMed 1103132, PubMed 9614966). Catalyzes the synthesis of cross-linked peptidoglycan from the lipid-linked precursors (PubMed 7030331). Required for localization of FtsN (PubMed 9282742). {ECO 0000269|PubMed 1103132, ECO 0000269|PubMed 7030331, ECO 0000269|PubMed 9282742, ECO 0000269|PubMed 9614966}. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoliWiki. # GO_component GO:0031226 intrinsic component of plasma membrane; IDA:EcoliWiki. # GO_component GO:0032153 cell division site; IDA:EcoliWiki. # GO_function GO:0008658 penicillin binding; IDA:EcoliWiki. # GO_function GO:0008955 peptidoglycan glycosyltransferase activity; IDA:EcoliWiki. # GO_process GO:0007049 cell cycle; IEA:UniProtKB-KW. # GO_process GO:0008360 regulation of cell shape; IEA:UniProtKB-KW. # GO_process GO:0009252 peptidoglycan biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0042493 response to drug; IMP:EcoliWiki. # GO_process GO:0051301 cell division; IMP:EcoliWiki. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_function GO:0043167 ion binding # GOslim_process GO:0007049 cell cycle # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0051301 cell division # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 3.40.710.10 -; 1. # INTERACTION FTSI_ECOLI Q8DQM0 divIB (xeno); NbExp=3; IntAct=EBI-548564, EBI-6446264; P0AEN4 ftsL; NbExp=4; IntAct=EBI-548564, EBI-1119082; P29131 ftsN; NbExp=3; IntAct=EBI-548564, EBI-1134233; P06136 ftsQ; NbExp=5; IntAct=EBI-548564, EBI-1130157; P0ABG4 ftsW; NbExp=7; IntAct=EBI-548564, EBI-1214767; P46022 mtgA; NbExp=3; IntAct=EBI-548564, EBI-558469; P58034 ymgF; NbExp=3; IntAct=EBI-548564, EBI-1214577; # IntAct P0AD68 18 # InterPro IPR001460 PCN-bd_Tpept # InterPro IPR005311 PBP_dimer # InterPro IPR012338 Beta-lactam/transpept-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03036 Chromosome # KEGG_Pathway ko00550 Peptidoglycan biosynthesis # Organism FTSI_ECOLI Escherichia coli (strain K12) # PATHWAY Cell wall biogenesis; peptidoglycan biosynthesis. {ECO 0000305}. # PATRIC 32115273 VBIEscCol129921_0088 # PIR A93123 ZPECP3 # Pfam PF00905 Transpeptidase # Pfam PF03717 PBP_dimer # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Peptidoglycan synthase FtsI {ECO 0000305} # RefSeq NP_414626 NC_000913.3 # RefSeq WP_000642196 NZ_LN832404.1 # SIMILARITY Belongs to the transpeptidase family. {ECO 0000305}. # SUBCELLULAR LOCATION FTSI_ECOLI Cell inner membrane {ECO 0000269|PubMed 2677607, ECO 0000269|PubMed 9614966}; Single- pass membrane protein {ECO 0000269|PubMed 2677607, ECO 0000269|PubMed 9614966}; Periplasmic side {ECO 0000269|PubMed 2677607, ECO 0000269|PubMed 9614966}. Note=The bulk of the molecule, except for the N-terminal membrane anchor region, protrudes into the periplasmic space (PubMed 2677607, PubMed 9614966). Localizes to the division septum during the later stages of cell growth and throughout septation (PubMed 9379897, PubMed 9603865, PubMed 9882665, PubMed 15601716). Localization is dependent on FtsZ, FtsA, FtsK, FtsQ, FtsL and FtsW, but not on FtsN (PubMed 9603865, PubMed 9882665, PubMed 11703663, PubMed 11807049). {ECO 0000269|PubMed 11703663, ECO 0000269|PubMed 11807049, ECO 0000269|PubMed 15601716, ECO 0000269|PubMed 2677607, ECO 0000269|PubMed 9379897, ECO 0000269|PubMed 9603865, ECO 0000269|PubMed 9614966, ECO 0000269|PubMed 9882665}. # SUBUNIT FTSI_ECOLI Homodimer (PubMed 20847002). Forms a complex with FtsW (PubMed 20847002). Interacts with FtsQ (PubMed 17185541). {ECO 0000269|PubMed 17185541, ECO 0000269|PubMed 20847002}. # SUPFAM SSF56519 SSF56519 # SUPFAM SSF56601 SSF56601 # eggNOG COG0768 LUCA # eggNOG ENOG4105CJN Bacteria BLAST swissprot:FTSI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FTSI_ECOLI BioCyc ECOL316407:JW0082-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0082-MONOMER BioCyc EcoCyc:EG10341-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10341-MONOMER BioCyc MetaCyc:EG10341-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10341-MONOMER COG COG0768 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0768 DIP DIP-47950N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47950N DOI 10.1007/BF00330881 http://dx.doi.org/10.1007/BF00330881 DOI 10.1007/BF00331346 http://dx.doi.org/10.1007/BF00331346 DOI 10.1007/s000180050157 http://dx.doi.org/10.1007/s000180050157 DOI 10.1016/0006-291X(81)91835-0 http://dx.doi.org/10.1016/0006-291X(81)91835-0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2690277 http://dx.doi.org/10.1042/bj2690277 DOI 10.1046/j.1365-2958.1997.4641833.x http://dx.doi.org/10.1046/j.1365-2958.1997.4641833.x DOI 10.1046/j.1365-2958.1997.5041869.x http://dx.doi.org/10.1046/j.1365-2958.1997.5041869.x DOI 10.1046/j.1365-2958.2001.02640.x http://dx.doi.org/10.1046/j.1365-2958.2001.02640.x DOI 10.1073/pnas.72.8.2999 http://dx.doi.org/10.1073/pnas.72.8.2999 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1099/mic.0.040071-0 http://dx.doi.org/10.1099/mic.0.040071-0 DOI 10.1099/mic.0.2006/000265-0 http://dx.doi.org/10.1099/mic.0.2006/000265-0 DOI 10.1111/j.1365-2958.1989.tb00278.x http://dx.doi.org/10.1111/j.1365-2958.1989.tb00278.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.186.2.490-502.2004 http://dx.doi.org/10.1128/JB.186.2.490-502.2004 DOI 10.1128/JB.187.1.320-328.2005 http://dx.doi.org/10.1128/JB.187.1.320-328.2005 DOI 10.1128/jb.184.4.904-912.2002 http://dx.doi.org/10.1128/jb.184.4.904-912.2002 DrugBank DB00267 http://www.drugbank.ca/drugs/DB00267 DrugBank DB00274 http://www.drugbank.ca/drugs/DB00274 DrugBank DB00303 http://www.drugbank.ca/drugs/DB00303 DrugBank DB00430 http://www.drugbank.ca/drugs/DB00430 DrugBank DB00438 http://www.drugbank.ca/drugs/DB00438 DrugBank DB01327 http://www.drugbank.ca/drugs/DB01327 DrugBank DB01328 http://www.drugbank.ca/drugs/DB01328 DrugBank DB01329 http://www.drugbank.ca/drugs/DB01329 DrugBank DB01331 http://www.drugbank.ca/drugs/DB01331 DrugBank DB01332 http://www.drugbank.ca/drugs/DB01332 DrugBank DB01413 http://www.drugbank.ca/drugs/DB01413 DrugBank DB01415 http://www.drugbank.ca/drugs/DB01415 DrugBank DB01416 http://www.drugbank.ca/drugs/DB01416 EC_number EC:2.4.1.129 {ECO:0000269|PubMed:7030331} http://www.genome.jp/dbget-bin/www_bget?EC:2.4.1.129 {ECO:0000269|PubMed:7030331} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K00137 http://www.ebi.ac.uk/ena/data/view/K00137 EMBL S49802 http://www.ebi.ac.uk/ena/data/view/S49802 EMBL S49875 http://www.ebi.ac.uk/ena/data/view/S49875 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X55034 http://www.ebi.ac.uk/ena/data/view/X55034 EMBL X55814 http://www.ebi.ac.uk/ena/data/view/X55814 ENZYME 2.4.1.129 {ECO:0000269|PubMed:7030331} http://enzyme.expasy.org/EC/2.4.1.129 {ECO:0000269|PubMed:7030331} EchoBASE EB0337 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0337 EcoGene EG10341 http://www.ecogene.org/geneInfo.php?eg_id=EG10341 EnsemblBacteria AAC73195 http://www.ensemblgenomes.org/id/AAC73195 EnsemblBacteria AAC73195 http://www.ensemblgenomes.org/id/AAC73195 EnsemblBacteria BAB96652 http://www.ensemblgenomes.org/id/BAB96652 EnsemblBacteria BAB96652 http://www.ensemblgenomes.org/id/BAB96652 EnsemblBacteria BAB96652 http://www.ensemblgenomes.org/id/BAB96652 EnsemblBacteria b0084 http://www.ensemblgenomes.org/id/b0084 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0031226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031226 GO_component GO:0032153 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032153 GO_function GO:0008658 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008658 GO_function GO:0008955 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008955 GO_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0009252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009252 GO_process GO:0042493 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 3.40.710.10 http://www.cathdb.info/version/latest/superfamily/3.40.710.10 GeneID 944799 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944799 HOGENOM HOG000049554 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000049554&db=HOGENOM6 InParanoid P0AD68 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AD68 IntAct P0AD68 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AD68* IntEnz 2.4.1.129 {ECO:0000269|PubMed:7030331} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.1.129 {ECO:0000269|PubMed:7030331} InterPro IPR001460 http://www.ebi.ac.uk/interpro/entry/IPR001460 InterPro IPR005311 http://www.ebi.ac.uk/interpro/entry/IPR005311 InterPro IPR012338 http://www.ebi.ac.uk/interpro/entry/IPR012338 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene ecj:JW0082 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0082 KEGG_Gene eco:b0084 http://www.genome.jp/dbget-bin/www_bget?eco:b0084 KEGG_Orthology KO:K03587 http://www.genome.jp/dbget-bin/www_bget?KO:K03587 KEGG_Pathway ko00550 http://www.genome.jp/kegg-bin/show_pathway?ko00550 KEGG_Reaction rn:R04519 http://www.genome.jp/dbget-bin/www_bget?rn:R04519 MINT MINT-1031950 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1031950 OMA SIEMDSC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SIEMDSC PSORT swissprot:FTSI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FTSI_ECOLI PSORT-B swissprot:FTSI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FTSI_ECOLI PSORT2 swissprot:FTSI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FTSI_ECOLI Pfam PF00905 http://pfam.xfam.org/family/PF00905 Pfam PF03717 http://pfam.xfam.org/family/PF03717 Phobius swissprot:FTSI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FTSI_ECOLI PhylomeDB P0AD68 http://phylomedb.org/?seqid=P0AD68 ProteinModelPortal P0AD68 http://www.proteinmodelportal.org/query/uniprot/P0AD68 PubMed 1103132 http://www.ncbi.nlm.nih.gov/pubmed/1103132 PubMed 11703663 http://www.ncbi.nlm.nih.gov/pubmed/11703663 PubMed 11807049 http://www.ncbi.nlm.nih.gov/pubmed/11807049 PubMed 1332942 http://www.ncbi.nlm.nih.gov/pubmed/1332942 PubMed 1447153 http://www.ncbi.nlm.nih.gov/pubmed/1447153 PubMed 14702319 http://www.ncbi.nlm.nih.gov/pubmed/14702319 PubMed 15601716 http://www.ncbi.nlm.nih.gov/pubmed/15601716 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17185541 http://www.ncbi.nlm.nih.gov/pubmed/17185541 PubMed 20847002 http://www.ncbi.nlm.nih.gov/pubmed/20847002 PubMed 2198024 http://www.ncbi.nlm.nih.gov/pubmed/2198024 PubMed 2677607 http://www.ncbi.nlm.nih.gov/pubmed/2677607 PubMed 2681146 http://www.ncbi.nlm.nih.gov/pubmed/2681146 PubMed 3049550 http://www.ncbi.nlm.nih.gov/pubmed/3049550 PubMed 3900044 http://www.ncbi.nlm.nih.gov/pubmed/3900044 PubMed 3911028 http://www.ncbi.nlm.nih.gov/pubmed/3911028 PubMed 6350821 http://www.ncbi.nlm.nih.gov/pubmed/6350821 PubMed 7030331 http://www.ncbi.nlm.nih.gov/pubmed/7030331 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9282742 http://www.ncbi.nlm.nih.gov/pubmed/9282742 PubMed 9379897 http://www.ncbi.nlm.nih.gov/pubmed/9379897 PubMed 9603865 http://www.ncbi.nlm.nih.gov/pubmed/9603865 PubMed 9614966 http://www.ncbi.nlm.nih.gov/pubmed/9614966 PubMed 9882665 http://www.ncbi.nlm.nih.gov/pubmed/9882665 RefSeq NP_414626 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414626 RefSeq WP_000642196 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000642196 SMR P0AD68 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AD68 STRING 511145.b0084 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0084&targetmode=cogs STRING COG0768 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0768&targetmode=cogs SUPFAM SSF56519 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56519 SUPFAM SSF56601 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56601 UniProtKB FTSI_ECOLI http://www.uniprot.org/uniprot/FTSI_ECOLI UniProtKB-AC P0AD68 http://www.uniprot.org/uniprot/P0AD68 charge swissprot:FTSI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FTSI_ECOLI eggNOG COG0768 http://eggnogapi.embl.de/nog_data/html/tree/COG0768 eggNOG ENOG4105CJN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CJN epestfind swissprot:FTSI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FTSI_ECOLI garnier swissprot:FTSI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FTSI_ECOLI helixturnhelix swissprot:FTSI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FTSI_ECOLI hmoment swissprot:FTSI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FTSI_ECOLI iep swissprot:FTSI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FTSI_ECOLI inforesidue swissprot:FTSI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FTSI_ECOLI octanol swissprot:FTSI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FTSI_ECOLI pepcoil swissprot:FTSI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FTSI_ECOLI pepdigest swissprot:FTSI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FTSI_ECOLI pepinfo swissprot:FTSI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FTSI_ECOLI pepnet swissprot:FTSI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FTSI_ECOLI pepstats swissprot:FTSI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FTSI_ECOLI pepwheel swissprot:FTSI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FTSI_ECOLI pepwindow swissprot:FTSI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FTSI_ECOLI sigcleave swissprot:FTSI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FTSI_ECOLI ## Database ID URL or Descriptions # BioGrid 4261261 6 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG14434 yzgL # Organism YZGL_ECOLI Escherichia coli (strain K12) # PATRIC 48667248 VBIEscCol107702_3889 # PIR F65138 Q4ECGG # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YZGL_ECOLI Putative uncharacterized protein YzgL # RefSeq WP_001181210 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA58225.1; Type=Erroneous initiation; Evidence={ECO 0000305}; BLAST swissprot:YZGL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YZGL_ECOLI BioCyc ECOL316407:JW3390-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3390-MONOMER BioCyc EcoCyc:G7752-MONOMER http://biocyc.org/getid?id=EcoCyc:G7752-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EcoGene EG14434 http://www.ecogene.org/geneInfo.php?eg_id=EG14434 EnsemblBacteria BAE77865 http://www.ensemblgenomes.org/id/BAE77865 EnsemblBacteria BAE77865 http://www.ensemblgenomes.org/id/BAE77865 EnsemblBacteria BAE77865 http://www.ensemblgenomes.org/id/BAE77865 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv KEGG_Gene ecj:JW3390 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3390 PSORT swissprot:YZGL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YZGL_ECOLI PSORT-B swissprot:YZGL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YZGL_ECOLI PSORT2 swissprot:YZGL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YZGL_ECOLI Phobius swissprot:YZGL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YZGL_ECOLI ProteinModelPortal P76692 http://www.proteinmodelportal.org/query/uniprot/P76692 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001181210 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001181210 STRING 316407.85676615 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85676615&targetmode=cogs UniProtKB YZGL_ECOLI http://www.uniprot.org/uniprot/YZGL_ECOLI UniProtKB-AC P76692 http://www.uniprot.org/uniprot/P76692 charge swissprot:YZGL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YZGL_ECOLI epestfind swissprot:YZGL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YZGL_ECOLI garnier swissprot:YZGL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YZGL_ECOLI helixturnhelix swissprot:YZGL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YZGL_ECOLI hmoment swissprot:YZGL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YZGL_ECOLI iep swissprot:YZGL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YZGL_ECOLI inforesidue swissprot:YZGL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YZGL_ECOLI octanol swissprot:YZGL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YZGL_ECOLI pepcoil swissprot:YZGL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YZGL_ECOLI pepdigest swissprot:YZGL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YZGL_ECOLI pepinfo swissprot:YZGL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YZGL_ECOLI pepnet swissprot:YZGL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YZGL_ECOLI pepstats swissprot:YZGL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YZGL_ECOLI pepwheel swissprot:YZGL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YZGL_ECOLI pepwindow swissprot:YZGL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YZGL_ECOLI sigcleave swissprot:YZGL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YZGL_ECOLI ## Database ID URL or Descriptions # AltName ARSC_ECOLI Arsenical pump modifier # BioGrid 4261140 6 # CATALYTIC ACTIVITY ARSC_ECOLI Arsenate + glutaredoxin = arsenite + glutaredoxin disulfide + H(2)O. # CDD cd03034 ArsC_ArsC # EcoGene EG12237 arsC # FUNCTION ARSC_ECOLI Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of ArsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance (By similarity). {ECO 0000250}. # GO_function GO:0008794 arsenate reductase (glutaredoxin) activity; ISS:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0046685 response to arsenic-containing substance; IMP:EcoCyc. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # Gene3D 3.40.30.10 -; 1. # IntAct P0AB96 2 # InterPro IPR006659 Arsenate_reductase # InterPro IPR006660 Arsenate_reductase-like # InterPro IPR012336 Thioredoxin-like_fold # KEGG_Brite ko01000 Enzymes # Organism ARSC_ECOLI Escherichia coli (strain K12) # PATRIC 32122460 VBIEscCol129921_3607 # PIR C56269 C56269 # PROSITE PS51353 ARSC # Pfam PF03960 ArsC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ARSC_ECOLI Arsenate reductase # RefSeq NP_417960 NC_000913.3 # RefSeq WP_000065769 NZ_LN832404.1 # SIMILARITY Belongs to the ArsC family. {ECO 0000305}. # SUPFAM SSF52833 SSF52833 # TIGRFAMs TIGR00014 arsC # eggNOG COG1393 LUCA # eggNOG ENOG4105K89 Bacteria BLAST swissprot:ARSC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARSC_ECOLI BioCyc ECOL316407:JW3470-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3470-MONOMER BioCyc EcoCyc:EG12237-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12237-MONOMER COG COG1393 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1393 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.20.4.1 http://www.genome.jp/dbget-bin/www_bget?EC:1.20.4.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X80057 http://www.ebi.ac.uk/ena/data/view/X80057 ENZYME 1.20.4.1 http://enzyme.expasy.org/EC/1.20.4.1 EchoBASE EB2149 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2149 EcoGene EG12237 http://www.ecogene.org/geneInfo.php?eg_id=EG12237 EnsemblBacteria AAC76528 http://www.ensemblgenomes.org/id/AAC76528 EnsemblBacteria AAC76528 http://www.ensemblgenomes.org/id/AAC76528 EnsemblBacteria BAE77791 http://www.ensemblgenomes.org/id/BAE77791 EnsemblBacteria BAE77791 http://www.ensemblgenomes.org/id/BAE77791 EnsemblBacteria BAE77791 http://www.ensemblgenomes.org/id/BAE77791 EnsemblBacteria b3503 http://www.ensemblgenomes.org/id/b3503 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008794 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008794 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0046685 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046685 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.30.10 http://www.cathdb.info/version/latest/superfamily/3.40.30.10 GeneID 948018 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948018 HOGENOM HOG000059717 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000059717&db=HOGENOM6 InParanoid P0AB96 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AB96 IntAct P0AB96 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AB96* IntEnz 1.20.4.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.20.4.1 InterPro IPR006659 http://www.ebi.ac.uk/interpro/entry/IPR006659 InterPro IPR006660 http://www.ebi.ac.uk/interpro/entry/IPR006660 InterPro IPR012336 http://www.ebi.ac.uk/interpro/entry/IPR012336 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3470 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3470 KEGG_Gene eco:b3503 http://www.genome.jp/dbget-bin/www_bget?eco:b3503 KEGG_Orthology KO:K00537 http://www.genome.jp/dbget-bin/www_bget?KO:K00537 OMA HYLENPP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HYLENPP PROSITE PS51353 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51353 PSORT swissprot:ARSC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARSC_ECOLI PSORT-B swissprot:ARSC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARSC_ECOLI PSORT2 swissprot:ARSC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARSC_ECOLI Pfam PF03960 http://pfam.xfam.org/family/PF03960 Phobius swissprot:ARSC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARSC_ECOLI PhylomeDB P0AB96 http://phylomedb.org/?seqid=P0AB96 ProteinModelPortal P0AB96 http://www.proteinmodelportal.org/query/uniprot/P0AB96 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7721697 http://www.ncbi.nlm.nih.gov/pubmed/7721697 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417960 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417960 RefSeq WP_000065769 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000065769 SMR P0AB96 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AB96 STRING 511145.b3503 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3503&targetmode=cogs STRING COG1393 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1393&targetmode=cogs SUPFAM SSF52833 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52833 TIGRFAMs TIGR00014 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00014 UniProtKB ARSC_ECOLI http://www.uniprot.org/uniprot/ARSC_ECOLI UniProtKB-AC P0AB96 http://www.uniprot.org/uniprot/P0AB96 charge swissprot:ARSC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARSC_ECOLI eggNOG COG1393 http://eggnogapi.embl.de/nog_data/html/tree/COG1393 eggNOG ENOG4105K89 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K89 epestfind swissprot:ARSC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARSC_ECOLI garnier swissprot:ARSC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARSC_ECOLI helixturnhelix swissprot:ARSC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARSC_ECOLI hmoment swissprot:ARSC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARSC_ECOLI iep swissprot:ARSC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARSC_ECOLI inforesidue swissprot:ARSC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARSC_ECOLI octanol swissprot:ARSC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARSC_ECOLI pepcoil swissprot:ARSC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARSC_ECOLI pepdigest swissprot:ARSC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARSC_ECOLI pepinfo swissprot:ARSC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARSC_ECOLI pepnet swissprot:ARSC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARSC_ECOLI pepstats swissprot:ARSC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARSC_ECOLI pepwheel swissprot:ARSC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARSC_ECOLI pepwindow swissprot:ARSC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARSC_ECOLI sigcleave swissprot:ARSC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARSC_ECOLI ## Database ID URL or Descriptions # AltName DSBB_ECOLI Disulfide oxidoreductase # BioGrid 4261815 428 # DISRUPTION PHENOTYPE Induction of the PhoP/PhoQ two-component regulatory system. {ECO:0000269|PubMed 22267510}. # EcoGene EG11393 dsbB # FUNCTION DSBB_ECOLI Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by oxidizing the DsbA protein. PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing (deletion of dsbA/dsbB, treatment with dithiothreitol). MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway. {ECO 0000269|PubMed 22267510, ECO 0000269|PubMed 7688471, ECO 0000269|PubMed 8430071}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0009055 electron carrier activity; IEA:UniProtKB-HAMAP. # GO_function GO:0015035 protein disulfide oxidoreductase activity; IMP:EcoCyc. # GO_process GO:0009408 response to heat; IMP:EcoCyc. # GO_process GO:0022900 electron transport chain; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0006950 response to stress # Gene3D 1.20.1550.10 -; 1. # HAMAP MF_00286 DsbB # INTERACTION DSBB_ECOLI P0AEG4 dsbA; NbExp=5; IntAct=EBI-1170740, EBI-549711; # InterPro IPR003752 DiS_bond_form_DsbB/BdbC # InterPro IPR022920 Disulphide_bond_form_DsbB # InterPro IPR023380 DsbB-like_dom # KEGG_Brite ko03110 Chaperones and folding catalysts # Organism DSBB_ECOLI Escherichia coli (strain K12) # PATRIC 32117616 VBIEscCol129921_1230 # PDB 2HI7 X-ray; 3.70 A; B=1-176 # PDB 2K73 NMR; -; A=1-176 # PDB 2K74 NMR; -; A=1-176 # PDB 2LEG NMR; -; B=1-176 # PDB 2LTQ NMR; -; A/D=1-176 # PDB 2ZUP X-ray; 3.70 A; B=1-176 # PDB 2ZUQ X-ray; 3.30 A; A/D=1-176 # PDB 3E9J X-ray; 3.70 A; C/F=1-176 # PIR F64864 F64864 # Pfam PF02600 DsbB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DSBB_ECOLI Disulfide bond formation protein B # RefSeq NP_415703 NC_000913.3 # RefSeq WP_000943459 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA23711.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAA24220.1; Type=Frameshift; Positions=130; Evidence={ECO 0000305}; # SIMILARITY Belongs to the DsbB family. {ECO 0000305}. # SUBCELLULAR LOCATION DSBB_ECOLI Cell inner membrane {ECO 0000269|PubMed 7957076, ECO 0000269|PubMed 8430071}; Multi- pass membrane protein {ECO 0000269|PubMed 7957076, ECO 0000269|PubMed 8430071}. # TCDB 5.A.2.1 the disulfide bond oxidoreductase b (dsbb) family # eggNOG COG1495 LUCA # eggNOG ENOG410635M Bacteria BLAST swissprot:DSBB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DSBB_ECOLI BioCyc ECOL316407:JW5182-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5182-MONOMER BioCyc EcoCyc:DSBBPROT-MONOMER http://biocyc.org/getid?id=EcoCyc:DSBBPROT-MONOMER BioCyc MetaCyc:DSBBPROT-MONOMER http://biocyc.org/getid?id=MetaCyc:DSBBPROT-MONOMER COG COG1495 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1495 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.90.15.7084 http://dx.doi.org/10.1073/pnas.90.15.7084 DOI 10.1073/pnas.90.3.1038 http://dx.doi.org/10.1073/pnas.90.3.1038 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/emboj/18.5.1192 http://dx.doi.org/10.1093/emboj/18.5.1192 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.06055-11 http://dx.doi.org/10.1128/JB.06055-11 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L03721 http://www.ebi.ac.uk/ena/data/view/L03721 EMBL M83655 http://www.ebi.ac.uk/ena/data/view/M83655 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1366 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1366 EcoGene EG11393 http://www.ecogene.org/geneInfo.php?eg_id=EG11393 EnsemblBacteria AAC74269 http://www.ensemblgenomes.org/id/AAC74269 EnsemblBacteria AAC74269 http://www.ensemblgenomes.org/id/AAC74269 EnsemblBacteria BAA36032 http://www.ensemblgenomes.org/id/BAA36032 EnsemblBacteria BAA36032 http://www.ensemblgenomes.org/id/BAA36032 EnsemblBacteria BAA36032 http://www.ensemblgenomes.org/id/BAA36032 EnsemblBacteria b1185 http://www.ensemblgenomes.org/id/b1185 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0015035 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015035 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GO_process GO:0022900 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022900 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 1.20.1550.10 http://www.cathdb.info/version/latest/superfamily/1.20.1550.10 GeneID 946344 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946344 HAMAP MF_00286 http://hamap.expasy.org/unirule/MF_00286 HOGENOM HOG000218135 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218135&db=HOGENOM6 InParanoid P0A6M2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6M2 IntAct P0A6M2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6M2* InterPro IPR003752 http://www.ebi.ac.uk/interpro/entry/IPR003752 InterPro IPR022920 http://www.ebi.ac.uk/interpro/entry/IPR022920 InterPro IPR023380 http://www.ebi.ac.uk/interpro/entry/IPR023380 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW5182 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5182 KEGG_Gene eco:b1185 http://www.genome.jp/dbget-bin/www_bget?eco:b1185 KEGG_Orthology KO:K03611 http://www.genome.jp/dbget-bin/www_bget?KO:K03611 MINT MINT-6742413 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-6742413 OMA YSAWEGL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YSAWEGL PDB 2HI7 http://www.ebi.ac.uk/pdbe-srv/view/entry/2HI7 PDB 2K73 http://www.ebi.ac.uk/pdbe-srv/view/entry/2K73 PDB 2K74 http://www.ebi.ac.uk/pdbe-srv/view/entry/2K74 PDB 2LEG http://www.ebi.ac.uk/pdbe-srv/view/entry/2LEG PDB 2LTQ http://www.ebi.ac.uk/pdbe-srv/view/entry/2LTQ PDB 2ZUP http://www.ebi.ac.uk/pdbe-srv/view/entry/2ZUP PDB 2ZUQ http://www.ebi.ac.uk/pdbe-srv/view/entry/2ZUQ PDB 3E9J http://www.ebi.ac.uk/pdbe-srv/view/entry/3E9J PDBsum 2HI7 http://www.ebi.ac.uk/pdbsum/2HI7 PDBsum 2K73 http://www.ebi.ac.uk/pdbsum/2K73 PDBsum 2K74 http://www.ebi.ac.uk/pdbsum/2K74 PDBsum 2LEG http://www.ebi.ac.uk/pdbsum/2LEG PDBsum 2LTQ http://www.ebi.ac.uk/pdbsum/2LTQ PDBsum 2ZUP http://www.ebi.ac.uk/pdbsum/2ZUP PDBsum 2ZUQ http://www.ebi.ac.uk/pdbsum/2ZUQ PDBsum 3E9J http://www.ebi.ac.uk/pdbsum/3E9J PSORT swissprot:DSBB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DSBB_ECOLI PSORT-B swissprot:DSBB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DSBB_ECOLI PSORT2 swissprot:DSBB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DSBB_ECOLI Pfam PF02600 http://pfam.xfam.org/family/PF02600 Phobius swissprot:DSBB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DSBB_ECOLI ProteinModelPortal P0A6M2 http://www.proteinmodelportal.org/query/uniprot/P0A6M2 PubMed 10064586 http://www.ncbi.nlm.nih.gov/pubmed/10064586 PubMed 1317851 http://www.ncbi.nlm.nih.gov/pubmed/1317851 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22267510 http://www.ncbi.nlm.nih.gov/pubmed/22267510 PubMed 7688471 http://www.ncbi.nlm.nih.gov/pubmed/7688471 PubMed 7957076 http://www.ncbi.nlm.nih.gov/pubmed/7957076 PubMed 8430071 http://www.ncbi.nlm.nih.gov/pubmed/8430071 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415703 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415703 RefSeq WP_000943459 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000943459 SMR P0A6M2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6M2 STRING 511145.b1185 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1185&targetmode=cogs STRING COG1495 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1495&targetmode=cogs TCDB 5.A.2.1 http://www.tcdb.org/search/result.php?tc=5.A.2.1 UniProtKB DSBB_ECOLI http://www.uniprot.org/uniprot/DSBB_ECOLI UniProtKB-AC P0A6M2 http://www.uniprot.org/uniprot/P0A6M2 charge swissprot:DSBB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DSBB_ECOLI eggNOG COG1495 http://eggnogapi.embl.de/nog_data/html/tree/COG1495 eggNOG ENOG410635M http://eggnogapi.embl.de/nog_data/html/tree/ENOG410635M epestfind swissprot:DSBB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DSBB_ECOLI garnier swissprot:DSBB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DSBB_ECOLI helixturnhelix swissprot:DSBB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DSBB_ECOLI hmoment swissprot:DSBB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DSBB_ECOLI iep swissprot:DSBB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DSBB_ECOLI inforesidue swissprot:DSBB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DSBB_ECOLI octanol swissprot:DSBB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DSBB_ECOLI pepcoil swissprot:DSBB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DSBB_ECOLI pepdigest swissprot:DSBB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DSBB_ECOLI pepinfo swissprot:DSBB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DSBB_ECOLI pepnet swissprot:DSBB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DSBB_ECOLI pepstats swissprot:DSBB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DSBB_ECOLI pepwheel swissprot:DSBB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DSBB_ECOLI pepwindow swissprot:DSBB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DSBB_ECOLI sigcleave swissprot:DSBB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DSBB_ECOLI ## Database ID URL or Descriptions # AltName RHAT_ECOLI L-rhamnose-H(+) transport protein # BioGrid 4263535 4 # EcoGene EG11313 rhaT # FUNCTION RHAT_ECOLI Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Can also transport L-mannose and L-xylose, but at reduced rates. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015153 rhamnose transmembrane transporter activity; IEA:UniProtKB-HAMAP. # GO_function GO:0015293 symporter activity; IDA:EcoCyc. # GO_process GO:0015762 rhamnose transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # HAMAP MF_01532 RhaT # INDUCTION Induced by L-rhamnose via the RhaR-RhaS regulatory cascade. Also induced by L-mannose or L-xylose. {ECO:0000269|PubMed 8757746}. # InterPro IPR004673 L-rhamnose-proton_sym_RhaT # KEGG_Brite ko02000 Transporters # Organism RHAT_ECOLI Escherichia coli (strain K12) # PATRIC 32123325 VBIEscCol129921_4023 # PIR B42436 B42436 # Pfam PF06379 RhaT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RHAT_ECOLI L-rhamnose-proton symporter # RefSeq NP_418343 NC_000913.3 # RefSeq WP_000063526 NZ_LN832404.1 # SIMILARITY Belongs to the L-rhamnose transporter (TC 2.A.7.6) family. {ECO 0000305}. # SUBCELLULAR LOCATION RHAT_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.7.6 the drug/metabolite transporter (dmt) superfamily # TIGRFAMs TIGR00776 RhaT # eggNOG COG0697 LUCA # eggNOG ENOG4107YRA Bacteria BLAST swissprot:RHAT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RHAT_ECOLI BioCyc ECOL316407:JW3878-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3878-MONOMER BioCyc EcoCyc:RHAT-MONOMER http://biocyc.org/getid?id=EcoCyc:RHAT-MONOMER BioCyc MetaCyc:RHAT-MONOMER http://biocyc.org/getid?id=MetaCyc:RHAT-MONOMER COG COG0697 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0697 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1099/00221287-138-6-1109 http://dx.doi.org/10.1099/00221287-138-6-1109 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL M85158 http://www.ebi.ac.uk/ena/data/view/M85158 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X60699 http://www.ebi.ac.uk/ena/data/view/X60699 EchoBASE EB1289 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1289 EcoGene EG11313 http://www.ecogene.org/geneInfo.php?eg_id=EG11313 EnsemblBacteria AAC76889 http://www.ensemblgenomes.org/id/AAC76889 EnsemblBacteria AAC76889 http://www.ensemblgenomes.org/id/AAC76889 EnsemblBacteria BAE77402 http://www.ensemblgenomes.org/id/BAE77402 EnsemblBacteria BAE77402 http://www.ensemblgenomes.org/id/BAE77402 EnsemblBacteria BAE77402 http://www.ensemblgenomes.org/id/BAE77402 EnsemblBacteria b3907 http://www.ensemblgenomes.org/id/b3907 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015153 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015153 GO_function GO:0015293 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293 GO_process GO:0015762 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015762 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948398 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948398 HAMAP MF_01532 http://hamap.expasy.org/unirule/MF_01532 HOGENOM HOG000274531 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000274531&db=HOGENOM6 InParanoid P27125 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P27125 InterPro IPR004673 http://www.ebi.ac.uk/interpro/entry/IPR004673 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3878 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3878 KEGG_Gene eco:b3907 http://www.genome.jp/dbget-bin/www_bget?eco:b3907 KEGG_Orthology KO:K02856 http://www.genome.jp/dbget-bin/www_bget?KO:K02856 OMA QFFFYGM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QFFFYGM PSORT swissprot:RHAT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RHAT_ECOLI PSORT-B swissprot:RHAT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RHAT_ECOLI PSORT2 swissprot:RHAT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RHAT_ECOLI Pfam PF06379 http://pfam.xfam.org/family/PF06379 Phobius swissprot:RHAT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RHAT_ECOLI PhylomeDB P27125 http://phylomedb.org/?seqid=P27125 ProteinModelPortal P27125 http://www.proteinmodelportal.org/query/uniprot/P27125 PubMed 1339463 http://www.ncbi.nlm.nih.gov/pubmed/1339463 PubMed 1551902 http://www.ncbi.nlm.nih.gov/pubmed/1551902 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8262918 http://www.ncbi.nlm.nih.gov/pubmed/8262918 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 8757746 http://www.ncbi.nlm.nih.gov/pubmed/8757746 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418343 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418343 RefSeq WP_000063526 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000063526 STRING 511145.b3907 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3907&targetmode=cogs STRING COG0697 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0697&targetmode=cogs TCDB 2.A.7.6 http://www.tcdb.org/search/result.php?tc=2.A.7.6 TIGRFAMs TIGR00776 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00776 UniProtKB RHAT_ECOLI http://www.uniprot.org/uniprot/RHAT_ECOLI UniProtKB-AC P27125 http://www.uniprot.org/uniprot/P27125 charge swissprot:RHAT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RHAT_ECOLI eggNOG COG0697 http://eggnogapi.embl.de/nog_data/html/tree/COG0697 eggNOG ENOG4107YRA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107YRA epestfind swissprot:RHAT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RHAT_ECOLI garnier swissprot:RHAT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RHAT_ECOLI helixturnhelix swissprot:RHAT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RHAT_ECOLI hmoment swissprot:RHAT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RHAT_ECOLI iep swissprot:RHAT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RHAT_ECOLI inforesidue swissprot:RHAT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RHAT_ECOLI octanol swissprot:RHAT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RHAT_ECOLI pepcoil swissprot:RHAT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RHAT_ECOLI pepdigest swissprot:RHAT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RHAT_ECOLI pepinfo swissprot:RHAT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RHAT_ECOLI pepnet swissprot:RHAT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RHAT_ECOLI pepstats swissprot:RHAT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RHAT_ECOLI pepwheel swissprot:RHAT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RHAT_ECOLI pepwindow swissprot:RHAT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RHAT_ECOLI sigcleave swissprot:RHAT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RHAT_ECOLI ## Database ID URL or Descriptions # AltName HEM4_ECOLI Hydroxymethylbilane hydrolyase [cyclizing] # AltName HEM4_ECOLI Uroporphyrinogen-III cosynthase # CATALYTIC ACTIVITY HEM4_ECOLI Hydroxymethylbilane = uroporphyrinogen III + H(2)O. # CDD cd06578 HemD # EcoGene EG10430 hemD # FUNCTION HEM4_ECOLI Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. {ECO 0000250}. # GO_function GO:0004852 uroporphyrinogen-III synthase activity; IDA:EcoCyc. # GO_process GO:0006782 protoporphyrinogen IX biosynthetic process; IDA:EcoCyc. # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0051186 cofactor metabolic process # IntAct P09126 3 # InterPro IPR003754 4pyrrol_synth_uPrphyn_synth # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00860 Porphyrin and chlorophyll metabolism # Organism HEM4_ECOLI Escherichia coli (strain K12) # PATHWAY Porphyrin-containing compound metabolism; protoporphyrin- IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate step 3/4. # PATRIC 32123107 VBIEscCol129921_3919 # PIR E65184 E65184 # Pfam PF02602 HEM4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HEM4_ECOLI Uroporphyrinogen-III synthase # RefSeq NP_418248 NC_000913.3 # RefSeq WP_000026046 NZ_LN832404.1 # SIMILARITY Belongs to the uroporphyrinogen-III synthase family. {ECO 0000305}. # SUBUNIT HEM4_ECOLI Monomer. # SUPFAM SSF69618 SSF69618 # UniPathway UPA00251 UER00320 # eggNOG COG1587 LUCA # eggNOG ENOG41076E6 Bacteria BLAST swissprot:HEM4_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HEM4_ECOLI BioCyc ECOL316407:JW3776-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3776-MONOMER BioCyc EcoCyc:UROGENIIISYN-MONOMER http://biocyc.org/getid?id=EcoCyc:UROGENIIISYN-MONOMER BioCyc MetaCyc:UROGENIIISYN-MONOMER http://biocyc.org/getid?id=MetaCyc:UROGENIIISYN-MONOMER COG COG1587 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1587 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2490613 http://dx.doi.org/10.1042/bj2490613 DOI 10.1093/nar/15.24.10583 http://dx.doi.org/10.1093/nar/15.24.10583 DOI 10.1093/nar/16.20.9871 http://dx.doi.org/10.1093/nar/16.20.9871 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.1.75 http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.75 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M17360 http://www.ebi.ac.uk/ena/data/view/M17360 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X12614 http://www.ebi.ac.uk/ena/data/view/X12614 EMBL Y00883 http://www.ebi.ac.uk/ena/data/view/Y00883 ENZYME 4.2.1.75 http://enzyme.expasy.org/EC/4.2.1.75 EchoBASE EB0425 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0425 EcoGene EG10430 http://www.ecogene.org/geneInfo.php?eg_id=EG10430 EnsemblBacteria AAC76807 http://www.ensemblgenomes.org/id/AAC76807 EnsemblBacteria AAC76807 http://www.ensemblgenomes.org/id/AAC76807 EnsemblBacteria BAE77497 http://www.ensemblgenomes.org/id/BAE77497 EnsemblBacteria BAE77497 http://www.ensemblgenomes.org/id/BAE77497 EnsemblBacteria BAE77497 http://www.ensemblgenomes.org/id/BAE77497 EnsemblBacteria b3804 http://www.ensemblgenomes.org/id/b3804 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004852 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004852 GO_process GO:0006782 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006782 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GeneID 948587 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948587 HOGENOM HOG000247993 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000247993&db=HOGENOM6 InParanoid P09126 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P09126 IntAct P09126 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P09126* IntEnz 4.2.1.75 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.75 InterPro IPR003754 http://www.ebi.ac.uk/interpro/entry/IPR003754 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3776 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3776 KEGG_Gene eco:b3804 http://www.genome.jp/dbget-bin/www_bget?eco:b3804 KEGG_Orthology KO:K01719 http://www.genome.jp/dbget-bin/www_bget?KO:K01719 KEGG_Pathway ko00860 http://www.genome.jp/kegg-bin/show_pathway?ko00860 KEGG_Reaction rn:R03165 http://www.genome.jp/dbget-bin/www_bget?rn:R03165 OMA FISTNAV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FISTNAV PSORT swissprot:HEM4_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HEM4_ECOLI PSORT-B swissprot:HEM4_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HEM4_ECOLI PSORT2 swissprot:HEM4_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HEM4_ECOLI Pfam PF02602 http://pfam.xfam.org/family/PF02602 Phobius swissprot:HEM4_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HEM4_ECOLI PhylomeDB P09126 http://phylomedb.org/?seqid=P09126 ProteinModelPortal P09126 http://www.proteinmodelportal.org/query/uniprot/P09126 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3040684 http://www.ncbi.nlm.nih.gov/pubmed/3040684 PubMed 3054815 http://www.ncbi.nlm.nih.gov/pubmed/3054815 PubMed 3277628 http://www.ncbi.nlm.nih.gov/pubmed/3277628 PubMed 3320969 http://www.ncbi.nlm.nih.gov/pubmed/3320969 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418248 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418248 RefSeq WP_000026046 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000026046 SMR P09126 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P09126 STRING 511145.b3804 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3804&targetmode=cogs STRING COG1587 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1587&targetmode=cogs SUPFAM SSF69618 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF69618 UniProtKB HEM4_ECOLI http://www.uniprot.org/uniprot/HEM4_ECOLI UniProtKB-AC P09126 http://www.uniprot.org/uniprot/P09126 charge swissprot:HEM4_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HEM4_ECOLI eggNOG COG1587 http://eggnogapi.embl.de/nog_data/html/tree/COG1587 eggNOG ENOG41076E6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41076E6 epestfind swissprot:HEM4_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HEM4_ECOLI garnier swissprot:HEM4_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HEM4_ECOLI helixturnhelix swissprot:HEM4_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HEM4_ECOLI hmoment swissprot:HEM4_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HEM4_ECOLI iep swissprot:HEM4_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HEM4_ECOLI inforesidue swissprot:HEM4_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HEM4_ECOLI octanol swissprot:HEM4_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HEM4_ECOLI pepcoil swissprot:HEM4_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HEM4_ECOLI pepdigest swissprot:HEM4_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HEM4_ECOLI pepinfo swissprot:HEM4_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HEM4_ECOLI pepnet swissprot:HEM4_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HEM4_ECOLI pepstats swissprot:HEM4_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HEM4_ECOLI pepwheel swissprot:HEM4_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HEM4_ECOLI pepwindow swissprot:HEM4_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HEM4_ECOLI sigcleave swissprot:HEM4_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HEM4_ECOLI ## Database ID URL or Descriptions # BioGrid 4261987 188 # CDD cd06174 MFS # EcoGene EG13346 yagG # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015293 symporter activity; IEA:UniProtKB-KW. # GO_process GO:0006814 sodium ion transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # IntAct P75683 2 # InterPro IPR001927 Na/Gal_symport # InterPro IPR018043 Na/Gal_symport_CS # InterPro IPR020846 MFS_dom # Organism YAGG_ECOLI Escherichia coli (strain K12) # PATRIC 32115661 VBIEscCol129921_0274 # PIR F64752 F64752 # PROSITE PS00872 NA_GALACTOSIDE_SYMP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAGG_ECOLI Uncharacterized symporter YagG # RefSeq NP_414804 NC_000913.3 # RefSeq WP_000192863 NZ_LN832404.1 # SIMILARITY Belongs to the sodium:galactoside symporter (TC 2.A.2) family. {ECO 0000305}. # SUBCELLULAR LOCATION YAGG_ECOLI Cell inner membrane {ECO 0000305}; Multi- pass membrane protein {ECO 0000305}. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.2.3:the glycoside-pentoside-hexuronide (gph) cation symporter family # TIGRFAMs TIGR00792 gph # eggNOG COG2211 LUCA # eggNOG ENOG4105CT4 Bacteria BLAST swissprot:YAGG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAGG_ECOLI BioCyc ECOL316407:JW0263-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0263-MONOMER BioCyc EcoCyc:B0270-MONOMER http://biocyc.org/getid?id=EcoCyc:B0270-MONOMER DIP DIP-11234N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11234N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EchoBASE EB3130 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3130 EcoGene EG13346 http://www.ecogene.org/geneInfo.php?eg_id=EG13346 EnsemblBacteria AAC73373 http://www.ensemblgenomes.org/id/AAC73373 EnsemblBacteria AAC73373 http://www.ensemblgenomes.org/id/AAC73373 EnsemblBacteria BAE76054 http://www.ensemblgenomes.org/id/BAE76054 EnsemblBacteria BAE76054 http://www.ensemblgenomes.org/id/BAE76054 EnsemblBacteria BAE76054 http://www.ensemblgenomes.org/id/BAE76054 EnsemblBacteria b0270 http://www.ensemblgenomes.org/id/b0270 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015293 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293 GO_process GO:0006814 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 944947 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944947 HOGENOM HOG000222022 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000222022&db=HOGENOM6 InParanoid P75683 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75683 IntAct P75683 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75683* InterPro IPR001927 http://www.ebi.ac.uk/interpro/entry/IPR001927 InterPro IPR018043 http://www.ebi.ac.uk/interpro/entry/IPR018043 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Gene ecj:JW0263 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0263 KEGG_Gene eco:b0270 http://www.genome.jp/dbget-bin/www_bget?eco:b0270 MINT MINT-1263876 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1263876 OMA WFLTAAC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WFLTAAC PROSITE PS00872 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00872 PSORT swissprot:YAGG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAGG_ECOLI PSORT-B swissprot:YAGG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAGG_ECOLI PSORT2 swissprot:YAGG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAGG_ECOLI Phobius swissprot:YAGG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAGG_ECOLI PhylomeDB P75683 http://phylomedb.org/?seqid=P75683 ProteinModelPortal P75683 http://www.proteinmodelportal.org/query/uniprot/P75683 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414804 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414804 RefSeq WP_000192863 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000192863 STRING 511145.b0270 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0270&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.2.3 http://www.tcdb.org/search/result.php?tc=2.A.2.3 TIGRFAMs TIGR00792 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00792 UniProtKB YAGG_ECOLI http://www.uniprot.org/uniprot/YAGG_ECOLI UniProtKB-AC P75683 http://www.uniprot.org/uniprot/P75683 charge swissprot:YAGG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAGG_ECOLI eggNOG COG2211 http://eggnogapi.embl.de/nog_data/html/tree/COG2211 eggNOG ENOG4105CT4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CT4 epestfind swissprot:YAGG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAGG_ECOLI garnier swissprot:YAGG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAGG_ECOLI helixturnhelix swissprot:YAGG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAGG_ECOLI hmoment swissprot:YAGG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAGG_ECOLI iep swissprot:YAGG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAGG_ECOLI inforesidue swissprot:YAGG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAGG_ECOLI octanol swissprot:YAGG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAGG_ECOLI pepcoil swissprot:YAGG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAGG_ECOLI pepdigest swissprot:YAGG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAGG_ECOLI pepinfo swissprot:YAGG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAGG_ECOLI pepnet swissprot:YAGG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAGG_ECOLI pepstats swissprot:YAGG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAGG_ECOLI pepwheel swissprot:YAGG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAGG_ECOLI pepwindow swissprot:YAGG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAGG_ECOLI sigcleave swissprot:YAGG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAGG_ECOLI ## Database ID URL or Descriptions # AltName RUTB_ECOLI Ureidoacrylate amidohydrolase # BRENDA 3.5.1.110 2026 # CATALYTIC ACTIVITY (Z)-2-methyl-ureidoacrylate peracid + H(2)O = (Z)-2-methyl-peroxyaminoacrylate + CO(2) + NH(3). {ECO:0000269|PubMed 20400551}. # CATALYTIC ACTIVITY (Z)-3-ureidoacrylate + H(2)O = (Z)-3- aminoacrylate + CO(2) + NH(3). {ECO:0000269|PubMed 20400551}. # CATALYTIC ACTIVITY (Z)-3-ureidoacrylate peracid + H(2)O = (Z)-3- peroxyaminoacrylate + CO(2) + NH(3). {ECO:0000269|PubMed 20400551}. # DISRUPTION PHENOTYPE Cells lacking this gene fail to grow on uridine as the sole source of nitrogen at room temperature. {ECO:0000269|PubMed 20400551}. # EcoGene EG13858 rutB # FUNCTION RUTB_ECOLI In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2. {ECO 0000269|PubMed 16540542, ECO 0000269|PubMed 20400551}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; IDA:UniProtKB. # GO_process GO:0006208 pyrimidine nucleobase catabolic process; IMP:EcoCyc. # GO_process GO:0006212 uracil catabolic process; IDA:UniProtKB. # GO_process GO:0019740 nitrogen utilization; IDA:UniProtKB. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.850 -; 1. # HAMAP MF_00830 RutB # INDUCTION RUTB_ECOLI Up-regulated by the nitrogen regulatory protein C (NtrC also called GlnG) and repressed by RutR. {ECO 0000269|PubMed 11121068, ECO 0000269|PubMed 17919280}. # InterPro IPR000868 Isochorismatase-like # InterPro IPR019916 IsoChorase_RutB # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00240 Pyrimidine metabolism # MISCELLANEOUS RUTB_ECOLI The Rut pathway degrades exogenous pyrimidines as the sole nitrogen source at room temperature but not at 37 degrees Celsius, a restriction that is apparently a consequence of an inadequate ability to remove toxic malonic semialdehyde at the higher temperature (RutE/YdfG function). # Organism RUTB_ECOLI Escherichia coli (strain K12) # PATRIC 32117251 VBIEscCol129921_1049 # PIR A64843 A64843 # Pfam PF00857 Isochorismatase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RUTB_ECOLI Peroxyureidoacrylate/ureidoacrylate amidohydrolase RutB # RefSeq NP_415531 NC_000913.3 # RefSeq WP_001393558 NZ_LN832404.1 # SIMILARITY Belongs to the isochorismatase family. RutB subfamily. {ECO 0000305}. # SUPFAM SSF52499 SSF52499 # TIGRFAMs TIGR03614 RutB # eggNOG COG1335 LUCA # eggNOG ENOG4106XMA Bacteria BLAST swissprot:RUTB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RUTB_ECOLI BioCyc ECOL316407:JW5139-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5139-MONOMER BioCyc EcoCyc:G6522-MONOMER http://biocyc.org/getid?id=EcoCyc:G6522-MONOMER BioCyc MetaCyc:G6522-MONOMER http://biocyc.org/getid?id=MetaCyc:G6522-MONOMER COG COG1335 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1335 DIP DIP-28106N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-28106N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0600521103 http://dx.doi.org/10.1073/pnas.0600521103 DOI 10.1073/pnas.97.26.14674 http://dx.doi.org/10.1073/pnas.97.26.14674 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.2007.05954.x http://dx.doi.org/10.1111/j.1365-2958.2007.05954.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00201-10 http://dx.doi.org/10.1128/JB.00201-10 EC_number EC:3.5.1.110 http://www.genome.jp/dbget-bin/www_bget?EC:3.5.1.110 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.5.1.110 http://enzyme.expasy.org/EC/3.5.1.110 EchoBASE EB3618 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3618 EcoGene EG13858 http://www.ecogene.org/geneInfo.php?eg_id=EG13858 EnsemblBacteria AAC74096 http://www.ensemblgenomes.org/id/AAC74096 EnsemblBacteria AAC74096 http://www.ensemblgenomes.org/id/AAC74096 EnsemblBacteria BAA35778 http://www.ensemblgenomes.org/id/BAA35778 EnsemblBacteria BAA35778 http://www.ensemblgenomes.org/id/BAA35778 EnsemblBacteria BAA35778 http://www.ensemblgenomes.org/id/BAA35778 EnsemblBacteria b1011 http://www.ensemblgenomes.org/id/b1011 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0016811 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016811 GO_process GO:0006208 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006208 GO_process GO:0006212 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006212 GO_process GO:0019740 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019740 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.850 http://www.cathdb.info/version/latest/superfamily/3.40.50.850 GeneID 945699 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945699 HAMAP MF_00830 http://hamap.expasy.org/unirule/MF_00830 HOGENOM HOG000078669 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000078669&db=HOGENOM6 InParanoid P75897 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75897 IntEnz 3.5.1.110 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.1.110 InterPro IPR000868 http://www.ebi.ac.uk/interpro/entry/IPR000868 InterPro IPR019916 http://www.ebi.ac.uk/interpro/entry/IPR019916 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5139 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5139 KEGG_Gene eco:b1011 http://www.genome.jp/dbget-bin/www_bget?eco:b1011 KEGG_Orthology KO:K09020 http://www.genome.jp/dbget-bin/www_bget?KO:K09020 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Reaction rn:R09947 http://www.genome.jp/dbget-bin/www_bget?rn:R09947 KEGG_Reaction rn:R09980 http://www.genome.jp/dbget-bin/www_bget?rn:R09980 OMA LAKGGWD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LAKGGWD PSORT swissprot:RUTB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RUTB_ECOLI PSORT-B swissprot:RUTB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RUTB_ECOLI PSORT2 swissprot:RUTB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RUTB_ECOLI Pfam PF00857 http://pfam.xfam.org/family/PF00857 Phobius swissprot:RUTB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RUTB_ECOLI PhylomeDB P75897 http://phylomedb.org/?seqid=P75897 ProteinModelPortal P75897 http://www.proteinmodelportal.org/query/uniprot/P75897 PubMed 11121068 http://www.ncbi.nlm.nih.gov/pubmed/11121068 PubMed 16540542 http://www.ncbi.nlm.nih.gov/pubmed/16540542 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17919280 http://www.ncbi.nlm.nih.gov/pubmed/17919280 PubMed 20400551 http://www.ncbi.nlm.nih.gov/pubmed/20400551 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415531 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415531 RefSeq WP_001393558 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001393558 SMR P75897 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75897 STRING 511145.b1011 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1011&targetmode=cogs STRING COG1335 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1335&targetmode=cogs SUPFAM SSF52499 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52499 TIGRFAMs TIGR03614 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03614 UniProtKB RUTB_ECOLI http://www.uniprot.org/uniprot/RUTB_ECOLI UniProtKB-AC P75897 http://www.uniprot.org/uniprot/P75897 charge swissprot:RUTB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RUTB_ECOLI eggNOG COG1335 http://eggnogapi.embl.de/nog_data/html/tree/COG1335 eggNOG ENOG4106XMA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106XMA epestfind swissprot:RUTB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RUTB_ECOLI garnier swissprot:RUTB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RUTB_ECOLI helixturnhelix swissprot:RUTB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RUTB_ECOLI hmoment swissprot:RUTB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RUTB_ECOLI iep swissprot:RUTB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RUTB_ECOLI inforesidue swissprot:RUTB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RUTB_ECOLI octanol swissprot:RUTB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RUTB_ECOLI pepcoil swissprot:RUTB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RUTB_ECOLI pepdigest swissprot:RUTB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RUTB_ECOLI pepinfo swissprot:RUTB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RUTB_ECOLI pepnet swissprot:RUTB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RUTB_ECOLI pepstats swissprot:RUTB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RUTB_ECOLI pepwheel swissprot:RUTB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RUTB_ECOLI pepwindow swissprot:RUTB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RUTB_ECOLI sigcleave swissprot:RUTB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RUTB_ECOLI ## Database ID URL or Descriptions # BioGrid 4263094 3 # CATALYTIC ACTIVITY ATP + methylphosphonate = alpha-D-ribose 1- methylphosphonate 5-triphosphate + adenine. {ECO:0000269|PubMed 22089136}. # EcoGene EG10716 phnG # FUNCTION PHNG_ECOLI Together with PhnH, PhnI and PhnL is required for the transfer of the ribose triphosphate moiety from ATP to methyl phosphonate. {ECO 0000269|PubMed 22089136}. # GO_component GO:0061694 alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase complex; IDA:EcoCyc. # GO_function GO:0061693 alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity; IEA:UniProtKB-EC. # GO_process GO:0015716 organic phosphonate transport; IEA:InterPro. # GO_process GO:0019700 organic phosphonate catabolic process; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006810 transport # GOslim_process GO:0009056 catabolic process # INTERACTION PHNG_ECOLI P16687 phnI; NbExp=6; IntAct=EBI-9126715, EBI-1127704; P04983 rbsA; NbExp=3; IntAct=EBI-9126715, EBI-1132449; # IntAct P16685 5 # InterPro IPR009609 Phosphonate_metab_PhnG # MISCELLANEOUS PHNG_ECOLI The sequence shown is that of strain K12. # Organism PHNG_ECOLI Escherichia coli (strain K12) # PATRIC 32123761 VBIEscCol129921_4229 # PDB 4XB6 X-ray; 1.70 A; A/E=1-150 # PIR D65219 D65219 # Pfam PF06754 PhnG # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PHNG_ECOLI Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnG # RefSeq NP_418525 NC_000913.3 # RefSeq WP_000542790 NZ_LN832404.1 # SIMILARITY Belongs to the PhnG family. {ECO 0000305}. # SUBUNIT Forms a complex with PhnH, PhnI, PhnJ and PhnK with the suggested composition PhnG(4)H(2)I(2)J(2)K. {ECO:0000269|PubMed 21705661}. # TIGRFAMs TIGR03293 PhnG_redo # eggNOG COG3624 LUCA # eggNOG ENOG4105KQZ Bacteria BLAST swissprot:PHNG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PHNG_ECOLI BioCyc ECOL316407:JW4062-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4062-MONOMER BioCyc EcoCyc:EG10716-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10716-MONOMER BioCyc MetaCyc:EG10716-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10716-MONOMER COG COG3624 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3624 DIP DIP-10486N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10486N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature10622 http://dx.doi.org/10.1038/nature10622 DOI 10.1073/pnas.1104922108 http://dx.doi.org/10.1073/pnas.1104922108 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.8.37 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.8.37 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D90227 http://www.ebi.ac.uk/ena/data/view/D90227 EMBL J05260 http://www.ebi.ac.uk/ena/data/view/J05260 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 2.7.8.37 http://enzyme.expasy.org/EC/2.7.8.37 EchoBASE EB0710 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0710 EcoGene EG10716 http://www.ecogene.org/geneInfo.php?eg_id=EG10716 EnsemblBacteria AAC77062 http://www.ensemblgenomes.org/id/AAC77062 EnsemblBacteria AAC77062 http://www.ensemblgenomes.org/id/AAC77062 EnsemblBacteria BAE78104 http://www.ensemblgenomes.org/id/BAE78104 EnsemblBacteria BAE78104 http://www.ensemblgenomes.org/id/BAE78104 EnsemblBacteria BAE78104 http://www.ensemblgenomes.org/id/BAE78104 EnsemblBacteria b4101 http://www.ensemblgenomes.org/id/b4101 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0061694 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061694 GO_function GO:0061693 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061693 GO_process GO:0015716 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015716 GO_process GO:0019700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019700 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GeneID 948618 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948618 HOGENOM HOG000127029 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000127029&db=HOGENOM6 InParanoid P16685 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P16685 IntAct P16685 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P16685* IntEnz 2.7.8.37 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.8.37 InterPro IPR009609 http://www.ebi.ac.uk/interpro/entry/IPR009609 KEGG_Gene ecj:JW4062 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4062 KEGG_Gene eco:b4101 http://www.genome.jp/dbget-bin/www_bget?eco:b4101 KEGG_Orthology KO:K06166 http://www.genome.jp/dbget-bin/www_bget?KO:K06166 OMA RQRWMSV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RQRWMSV PDB 4XB6 http://www.ebi.ac.uk/pdbe-srv/view/entry/4XB6 PDBsum 4XB6 http://www.ebi.ac.uk/pdbsum/4XB6 PSORT swissprot:PHNG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PHNG_ECOLI PSORT-B swissprot:PHNG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PHNG_ECOLI PSORT2 swissprot:PHNG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PHNG_ECOLI Pfam PF06754 http://pfam.xfam.org/family/PF06754 Phobius swissprot:PHNG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PHNG_ECOLI PhylomeDB P16685 http://phylomedb.org/?seqid=P16685 ProteinModelPortal P16685 http://www.proteinmodelportal.org/query/uniprot/P16685 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1840580 http://www.ncbi.nlm.nih.gov/pubmed/1840580 PubMed 2155230 http://www.ncbi.nlm.nih.gov/pubmed/2155230 PubMed 21705661 http://www.ncbi.nlm.nih.gov/pubmed/21705661 PubMed 22089136 http://www.ncbi.nlm.nih.gov/pubmed/22089136 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418525 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418525 RefSeq WP_000542790 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000542790 SMR P16685 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P16685 STRING 511145.b4101 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4101&targetmode=cogs STRING COG3624 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3624&targetmode=cogs TIGRFAMs TIGR03293 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03293 UniProtKB PHNG_ECOLI http://www.uniprot.org/uniprot/PHNG_ECOLI UniProtKB-AC P16685 http://www.uniprot.org/uniprot/P16685 charge swissprot:PHNG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PHNG_ECOLI eggNOG COG3624 http://eggnogapi.embl.de/nog_data/html/tree/COG3624 eggNOG ENOG4105KQZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KQZ epestfind swissprot:PHNG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PHNG_ECOLI garnier swissprot:PHNG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PHNG_ECOLI helixturnhelix swissprot:PHNG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PHNG_ECOLI hmoment swissprot:PHNG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PHNG_ECOLI iep swissprot:PHNG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PHNG_ECOLI inforesidue swissprot:PHNG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PHNG_ECOLI octanol swissprot:PHNG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PHNG_ECOLI pepcoil swissprot:PHNG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PHNG_ECOLI pepdigest swissprot:PHNG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PHNG_ECOLI pepinfo swissprot:PHNG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PHNG_ECOLI pepnet swissprot:PHNG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PHNG_ECOLI pepstats swissprot:PHNG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PHNG_ECOLI pepwheel swissprot:PHNG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PHNG_ECOLI pepwindow swissprot:PHNG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PHNG_ECOLI sigcleave swissprot:PHNG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PHNG_ECOLI ## Database ID URL or Descriptions # AltName SFSB_ECOLI Ner-like protein # BioGrid 4263464 4 # EcoGene EG10656 nlp # FUNCTION SFSB_ECOLI This protein is involved in positive regulation of the metabolism of sugars. {ECO 0000250}. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; ISS:EcoCyc. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; ISS:EcoCyc. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.260.40 -; 1. # IntAct P0ACH1 6 # InterPro IPR010982 Lambda_DNA-bd_dom # KEGG_Brite ko03000 Transcription factors # Organism SFSB_ECOLI Escherichia coli (strain K12) # PATRIC 32121796 VBIEscCol129921_3282 # PIR JV0027 BVECNP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SFSB_ECOLI Sugar fermentation stimulation protein B # RefSeq NP_417655 NC_000913.3 # RefSeq WP_000445413 NZ_LN832404.1 # SIMILARITY Belongs to the ner transcriptional regulatory family. {ECO 0000305}. # SUPFAM SSF47413 SSF47413 # eggNOG COG3423 LUCA # eggNOG ENOG4105HVQ Bacteria BLAST swissprot:SFSB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SFSB_ECOLI BioCyc ECOL316407:JW3155-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3155-MONOMER BioCyc EcoCyc:EG10656-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10656-MONOMER COG COG3423 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3423 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X68873 http://www.ebi.ac.uk/ena/data/view/X68873 EchoBASE EB0650 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0650 EcoGene EG10656 http://www.ecogene.org/geneInfo.php?eg_id=EG10656 EnsemblBacteria AAC76220 http://www.ensemblgenomes.org/id/AAC76220 EnsemblBacteria AAC76220 http://www.ensemblgenomes.org/id/AAC76220 EnsemblBacteria BAE77232 http://www.ensemblgenomes.org/id/BAE77232 EnsemblBacteria BAE77232 http://www.ensemblgenomes.org/id/BAE77232 EnsemblBacteria BAE77232 http://www.ensemblgenomes.org/id/BAE77232 EnsemblBacteria b3188 http://www.ensemblgenomes.org/id/b3188 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.260.40 http://www.cathdb.info/version/latest/superfamily/1.10.260.40 GeneID 947960 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947960 HOGENOM HOG000040880 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000040880&db=HOGENOM6 IntAct P0ACH1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACH1* InterPro IPR010982 http://www.ebi.ac.uk/interpro/entry/IPR010982 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW3155 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3155 KEGG_Gene eco:b3188 http://www.genome.jp/dbget-bin/www_bget?eco:b3188 KEGG_Orthology KO:K07724 http://www.genome.jp/dbget-bin/www_bget?KO:K07724 OMA YHDPITH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YHDPITH PSORT swissprot:SFSB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SFSB_ECOLI PSORT-B swissprot:SFSB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SFSB_ECOLI PSORT2 swissprot:SFSB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SFSB_ECOLI Phobius swissprot:SFSB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SFSB_ECOLI ProteinModelPortal P0ACH1 http://www.proteinmodelportal.org/query/uniprot/P0ACH1 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2670911 http://www.ncbi.nlm.nih.gov/pubmed/2670911 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417655 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417655 RefSeq WP_000445413 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000445413 SMR P0ACH1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACH1 STRING 511145.b3188 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3188&targetmode=cogs STRING COG3423 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3423&targetmode=cogs SUPFAM SSF47413 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47413 UniProtKB SFSB_ECOLI http://www.uniprot.org/uniprot/SFSB_ECOLI UniProtKB-AC P0ACH1 http://www.uniprot.org/uniprot/P0ACH1 charge swissprot:SFSB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SFSB_ECOLI eggNOG COG3423 http://eggnogapi.embl.de/nog_data/html/tree/COG3423 eggNOG ENOG4105HVQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105HVQ epestfind swissprot:SFSB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SFSB_ECOLI garnier swissprot:SFSB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SFSB_ECOLI helixturnhelix swissprot:SFSB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SFSB_ECOLI hmoment swissprot:SFSB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SFSB_ECOLI iep swissprot:SFSB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SFSB_ECOLI inforesidue swissprot:SFSB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SFSB_ECOLI octanol swissprot:SFSB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SFSB_ECOLI pepcoil swissprot:SFSB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SFSB_ECOLI pepdigest swissprot:SFSB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SFSB_ECOLI pepinfo swissprot:SFSB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SFSB_ECOLI pepnet swissprot:SFSB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SFSB_ECOLI pepstats swissprot:SFSB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SFSB_ECOLI pepwheel swissprot:SFSB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SFSB_ECOLI pepwindow swissprot:SFSB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SFSB_ECOLI sigcleave swissprot:SFSB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SFSB_ECOLI ## Database ID URL or Descriptions # BioGrid 4259168 11 # EcoGene EG14073 yeiS # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # InterPro IPR020155 Uncharacterised_YeiS # Organism YEIS_ECOLI Escherichia coli (strain K12) # PATRIC 32119633 VBIEscCol129921_2227 # PIR H64982 H64982 # Pfam PF10808 DUF2542 # ProDom PD058881 Uncharacterised_YeiS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEIS_ECOLI Uncharacterized protein YeiS # RefSeq NP_416650 NC_000913.3 # RefSeq WP_000383096 NZ_CP014272.1 # SUBCELLULAR LOCATION YEIS_ECOLI Membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. # eggNOG ENOG4105Y9N Bacteria # eggNOG ENOG41129X4 LUCA BLAST swissprot:YEIS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEIS_ECOLI BioCyc ECOL316407:JW5359-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5359-MONOMER BioCyc EcoCyc:G7144-MONOMER http://biocyc.org/getid?id=EcoCyc:G7144-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3826 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3826 EcoGene EG14073 http://www.ecogene.org/geneInfo.php?eg_id=EG14073 EnsemblBacteria AAC75206 http://www.ensemblgenomes.org/id/AAC75206 EnsemblBacteria AAC75206 http://www.ensemblgenomes.org/id/AAC75206 EnsemblBacteria BAE76622 http://www.ensemblgenomes.org/id/BAE76622 EnsemblBacteria BAE76622 http://www.ensemblgenomes.org/id/BAE76622 EnsemblBacteria BAE76622 http://www.ensemblgenomes.org/id/BAE76622 EnsemblBacteria b2145 http://www.ensemblgenomes.org/id/b2145 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GeneID 948983 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948983 HOGENOM HOG000009511 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009511&db=HOGENOM6 InterPro IPR020155 http://www.ebi.ac.uk/interpro/entry/IPR020155 KEGG_Gene ecj:JW5359 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5359 KEGG_Gene eco:b2145 http://www.genome.jp/dbget-bin/www_bget?eco:b2145 OMA HADPIQY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HADPIQY PSORT swissprot:YEIS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEIS_ECOLI PSORT-B swissprot:YEIS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEIS_ECOLI PSORT2 swissprot:YEIS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEIS_ECOLI Pfam PF10808 http://pfam.xfam.org/family/PF10808 Phobius swissprot:YEIS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEIS_ECOLI ProteinModelPortal P64536 http://www.proteinmodelportal.org/query/uniprot/P64536 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416650 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416650 RefSeq WP_000383096 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000383096 STRING 511145.b2145 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2145&targetmode=cogs UniProtKB YEIS_ECOLI http://www.uniprot.org/uniprot/YEIS_ECOLI UniProtKB-AC P64536 http://www.uniprot.org/uniprot/P64536 charge swissprot:YEIS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEIS_ECOLI eggNOG ENOG4105Y9N http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105Y9N eggNOG ENOG41129X4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41129X4 epestfind swissprot:YEIS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEIS_ECOLI garnier swissprot:YEIS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEIS_ECOLI helixturnhelix swissprot:YEIS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEIS_ECOLI hmoment swissprot:YEIS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEIS_ECOLI iep swissprot:YEIS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEIS_ECOLI inforesidue swissprot:YEIS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEIS_ECOLI octanol swissprot:YEIS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEIS_ECOLI pepcoil swissprot:YEIS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEIS_ECOLI pepdigest swissprot:YEIS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEIS_ECOLI pepinfo swissprot:YEIS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEIS_ECOLI pepnet swissprot:YEIS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEIS_ECOLI pepstats swissprot:YEIS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEIS_ECOLI pepwheel swissprot:YEIS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEIS_ECOLI pepwindow swissprot:YEIS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEIS_ECOLI sigcleave swissprot:YEIS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEIS_ECOLI ## Database ID URL or Descriptions # BioGrid 4260654 16 # EcoGene EG11126 yciF # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_process GO:0006950 response to stress # Gene3D 1.20.1260.10 -; 1. # IntAct P21362 6 # InterPro IPR009078 Ferritin-like_SF # InterPro IPR010287 DUF892 # InterPro IPR012347 Ferritin-rel # Organism YCIF_ECOLI Escherichia coli (strain K12) # PATRIC 32117776 VBIEscCol129921_1308 # PDB 2GS4 X-ray; 2.00 A; A/B=1-166 # PIR S07795 S07795 # Pfam PF05974 DUF892 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCIF_ECOLI Protein YciF # RefSeq NP_415774 NC_000913.3 # RefSeq WP_001056490 NZ_LN832404.1 # SUBUNIT Homodimer. {ECO:0000269|PubMed 17001035}. # SUPFAM SSF47240 SSF47240 # eggNOG COG3685 LUCA # eggNOG ENOG4108Z9Z Bacteria BLAST swissprot:YCIF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCIF_ECOLI BioCyc ECOL316407:JW1250-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1250-MONOMER BioCyc EcoCyc:EG11126-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11126-MONOMER DIP DIP-11580N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11580N DOI 10.1007/BF00282791 http://dx.doi.org/10.1007/BF00282791 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1110/ps.062307706 http://dx.doi.org/10.1110/ps.062307706 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AF062842 http://www.ebi.ac.uk/ena/data/view/AF062842 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U23489 http://www.ebi.ac.uk/ena/data/view/U23489 EMBL U23490 http://www.ebi.ac.uk/ena/data/view/U23490 EMBL U23491 http://www.ebi.ac.uk/ena/data/view/U23491 EMBL U23492 http://www.ebi.ac.uk/ena/data/view/U23492 EMBL U25417 http://www.ebi.ac.uk/ena/data/view/U25417 EMBL U25419 http://www.ebi.ac.uk/ena/data/view/U25419 EMBL U25420 http://www.ebi.ac.uk/ena/data/view/U25420 EMBL U25421 http://www.ebi.ac.uk/ena/data/view/U25421 EMBL U25423 http://www.ebi.ac.uk/ena/data/view/U25423 EMBL U25427 http://www.ebi.ac.uk/ena/data/view/U25427 EMBL X13583 http://www.ebi.ac.uk/ena/data/view/X13583 EchoBASE EB1116 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1116 EcoGene EG11126 http://www.ecogene.org/geneInfo.php?eg_id=EG11126 EnsemblBacteria AAC74340 http://www.ensemblgenomes.org/id/AAC74340 EnsemblBacteria AAC74340 http://www.ensemblgenomes.org/id/AAC74340 EnsemblBacteria BAA14790 http://www.ensemblgenomes.org/id/BAA14790 EnsemblBacteria BAA14790 http://www.ensemblgenomes.org/id/BAA14790 EnsemblBacteria BAA14790 http://www.ensemblgenomes.org/id/BAA14790 EnsemblBacteria b1258 http://www.ensemblgenomes.org/id/b1258 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 1.20.1260.10 http://www.cathdb.info/version/latest/superfamily/1.20.1260.10 GeneID 947133 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947133 HOGENOM HOG000025592 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000025592&db=HOGENOM6 InParanoid P21362 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P21362 IntAct P21362 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P21362* InterPro IPR009078 http://www.ebi.ac.uk/interpro/entry/IPR009078 InterPro IPR010287 http://www.ebi.ac.uk/interpro/entry/IPR010287 InterPro IPR012347 http://www.ebi.ac.uk/interpro/entry/IPR012347 KEGG_Gene ecj:JW1250 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1250 KEGG_Gene eco:b1258 http://www.genome.jp/dbget-bin/www_bget?eco:b1258 OMA ARAKTCE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ARAKTCE PDB 2GS4 http://www.ebi.ac.uk/pdbe-srv/view/entry/2GS4 PDBsum 2GS4 http://www.ebi.ac.uk/pdbsum/2GS4 PSORT swissprot:YCIF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCIF_ECOLI PSORT-B swissprot:YCIF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCIF_ECOLI PSORT2 swissprot:YCIF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCIF_ECOLI Pfam PF05974 http://pfam.xfam.org/family/PF05974 Phobius swissprot:YCIF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCIF_ECOLI PhylomeDB P21362 http://phylomedb.org/?seqid=P21362 ProteinModelPortal P21362 http://www.proteinmodelportal.org/query/uniprot/P21362 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17001035 http://www.ncbi.nlm.nih.gov/pubmed/17001035 PubMed 3058546 http://www.ncbi.nlm.nih.gov/pubmed/3058546 PubMed 8455549 http://www.ncbi.nlm.nih.gov/pubmed/8455549 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415774 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415774 RefSeq WP_001056490 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001056490 SMR P21362 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P21362 STRING 511145.b1258 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1258&targetmode=cogs SUPFAM SSF47240 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47240 UniProtKB YCIF_ECOLI http://www.uniprot.org/uniprot/YCIF_ECOLI UniProtKB-AC P21362 http://www.uniprot.org/uniprot/P21362 charge swissprot:YCIF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCIF_ECOLI eggNOG COG3685 http://eggnogapi.embl.de/nog_data/html/tree/COG3685 eggNOG ENOG4108Z9Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Z9Z epestfind swissprot:YCIF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCIF_ECOLI garnier swissprot:YCIF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCIF_ECOLI helixturnhelix swissprot:YCIF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCIF_ECOLI hmoment swissprot:YCIF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCIF_ECOLI iep swissprot:YCIF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCIF_ECOLI inforesidue swissprot:YCIF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCIF_ECOLI octanol swissprot:YCIF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCIF_ECOLI pepcoil swissprot:YCIF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCIF_ECOLI pepdigest swissprot:YCIF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCIF_ECOLI pepinfo swissprot:YCIF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCIF_ECOLI pepnet swissprot:YCIF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCIF_ECOLI pepstats swissprot:YCIF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCIF_ECOLI pepwheel swissprot:YCIF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCIF_ECOLI pepwindow swissprot:YCIF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCIF_ECOLI sigcleave swissprot:YCIF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCIF_ECOLI ## Database ID URL or Descriptions # BioGrid 4259292 244 # EcoGene EG12921 yhfZ # Gene3D 1.10.10.10 -; 1. # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR032791 YhfZ_C # Organism YHFZ_ECOLI Escherichia coli (strain K12) # PATRIC 32122198 VBIEscCol129921_3476 # Pfam PF14502 HTH_41 # Pfam PF14503 YhfZ_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHFZ_ECOLI Uncharacterized protein YhfZ # RefSeq WP_001254790 NZ_LN832404.1 # RefSeq YP_026214 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA58180.1; Type=Frameshift; Positions=10; Evidence={ECO 0000305}; # eggNOG ENOG4108M21 Bacteria # eggNOG ENOG410YBQW LUCA BLAST swissprot:YHFZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHFZ_ECOLI BioCyc ECOL316407:JW5948-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5948-MONOMER BioCyc EcoCyc:G7735-MONOMER http://biocyc.org/getid?id=EcoCyc:G7735-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2757 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2757 EcoGene EG12921 http://www.ecogene.org/geneInfo.php?eg_id=EG12921 EnsemblBacteria AAT48178 http://www.ensemblgenomes.org/id/AAT48178 EnsemblBacteria AAT48178 http://www.ensemblgenomes.org/id/AAT48178 EnsemblBacteria BAE77908 http://www.ensemblgenomes.org/id/BAE77908 EnsemblBacteria BAE77908 http://www.ensemblgenomes.org/id/BAE77908 EnsemblBacteria BAE77908 http://www.ensemblgenomes.org/id/BAE77908 EnsemblBacteria b3383 http://www.ensemblgenomes.org/id/b3383 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 947897 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947897 HOGENOM HOG000125497 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125497&db=HOGENOM6 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR032791 http://www.ebi.ac.uk/interpro/entry/IPR032791 KEGG_Gene ecj:JW5948 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5948 KEGG_Gene eco:b3383 http://www.genome.jp/dbget-bin/www_bget?eco:b3383 OMA PFYFAHM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PFYFAHM PSORT swissprot:YHFZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHFZ_ECOLI PSORT-B swissprot:YHFZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHFZ_ECOLI PSORT2 swissprot:YHFZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHFZ_ECOLI Pfam PF14502 http://pfam.xfam.org/family/PF14502 Pfam PF14503 http://pfam.xfam.org/family/PF14503 Phobius swissprot:YHFZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHFZ_ECOLI ProteinModelPortal P45552 http://www.proteinmodelportal.org/query/uniprot/P45552 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001254790 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001254790 RefSeq YP_026214 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026214 SMR P45552 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45552 STRING 511145.b3383 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3383&targetmode=cogs UniProtKB YHFZ_ECOLI http://www.uniprot.org/uniprot/YHFZ_ECOLI UniProtKB-AC P45552 http://www.uniprot.org/uniprot/P45552 charge swissprot:YHFZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHFZ_ECOLI eggNOG ENOG4108M21 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108M21 eggNOG ENOG410YBQW http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YBQW epestfind swissprot:YHFZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHFZ_ECOLI garnier swissprot:YHFZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHFZ_ECOLI helixturnhelix swissprot:YHFZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHFZ_ECOLI hmoment swissprot:YHFZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHFZ_ECOLI iep swissprot:YHFZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHFZ_ECOLI inforesidue swissprot:YHFZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHFZ_ECOLI octanol swissprot:YHFZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHFZ_ECOLI pepcoil swissprot:YHFZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHFZ_ECOLI pepdigest swissprot:YHFZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHFZ_ECOLI pepinfo swissprot:YHFZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHFZ_ECOLI pepnet swissprot:YHFZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHFZ_ECOLI pepstats swissprot:YHFZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHFZ_ECOLI pepwheel swissprot:YHFZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHFZ_ECOLI pepwindow swissprot:YHFZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHFZ_ECOLI sigcleave swissprot:YHFZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHFZ_ECOLI ## Database ID URL or Descriptions # BioGrid 4262363 11 # EcoGene EG12991 yghG # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0009279 cell outer membrane; ISS:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006950 response to stress # InterPro IPR016502 T2SSS_2 # Organism YGHG_ECOLI Escherichia coli (strain K12) # PATRIC 32121358 VBIEscCol129921_3066 # PIR A65083 A65083 # PIRSF PIRSF007010 UCP007010 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF16549 T2SSS_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGHG_ECOLI Uncharacterized lipoprotein YghG # RefSeq NP_417445 NC_000913.3 # RefSeq WP_001324279 NZ_LN832404.1 # SUBCELLULAR LOCATION YGHG_ECOLI Cell membrane {ECO 0000255|PROSITE- ProRule PRU00303}; Lipid-anchor {ECO 0000255|PROSITE- ProRule PRU00303}. # eggNOG ENOG410765S Bacteria # eggNOG ENOG410Z3FE LUCA BLAST swissprot:YGHG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGHG_ECOLI BioCyc ECOL316407:JW2938-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2938-MONOMER BioCyc EcoCyc:G7538-MONOMER http://biocyc.org/getid?id=EcoCyc:G7538-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2815 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2815 EcoGene EG12991 http://www.ecogene.org/geneInfo.php?eg_id=EG12991 EnsemblBacteria AAC76007 http://www.ensemblgenomes.org/id/AAC76007 EnsemblBacteria AAC76007 http://www.ensemblgenomes.org/id/AAC76007 EnsemblBacteria BAE77032 http://www.ensemblgenomes.org/id/BAE77032 EnsemblBacteria BAE77032 http://www.ensemblgenomes.org/id/BAE77032 EnsemblBacteria BAE77032 http://www.ensemblgenomes.org/id/BAE77032 EnsemblBacteria b2971 http://www.ensemblgenomes.org/id/b2971 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 947470 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947470 HOGENOM HOG000124903 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000124903&db=HOGENOM6 InterPro IPR016502 http://www.ebi.ac.uk/interpro/entry/IPR016502 KEGG_Gene ecj:JW2938 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2938 KEGG_Gene eco:b2971 http://www.genome.jp/dbget-bin/www_bget?eco:b2971 OMA HQANKIN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HQANKIN PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YGHG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGHG_ECOLI PSORT-B swissprot:YGHG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGHG_ECOLI PSORT2 swissprot:YGHG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGHG_ECOLI Pfam PF16549 http://pfam.xfam.org/family/PF16549 Phobius swissprot:YGHG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGHG_ECOLI ProteinModelPortal Q46835 http://www.proteinmodelportal.org/query/uniprot/Q46835 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417445 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417445 RefSeq WP_001324279 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001324279 STRING 511145.b2971 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2971&targetmode=cogs UniProtKB YGHG_ECOLI http://www.uniprot.org/uniprot/YGHG_ECOLI UniProtKB-AC Q46835 http://www.uniprot.org/uniprot/Q46835 charge swissprot:YGHG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGHG_ECOLI eggNOG ENOG410765S http://eggnogapi.embl.de/nog_data/html/tree/ENOG410765S eggNOG ENOG410Z3FE http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Z3FE epestfind swissprot:YGHG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGHG_ECOLI garnier swissprot:YGHG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGHG_ECOLI helixturnhelix swissprot:YGHG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGHG_ECOLI hmoment swissprot:YGHG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGHG_ECOLI iep swissprot:YGHG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGHG_ECOLI inforesidue swissprot:YGHG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGHG_ECOLI octanol swissprot:YGHG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGHG_ECOLI pepcoil swissprot:YGHG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGHG_ECOLI pepdigest swissprot:YGHG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGHG_ECOLI pepinfo swissprot:YGHG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGHG_ECOLI pepnet swissprot:YGHG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGHG_ECOLI pepstats swissprot:YGHG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGHG_ECOLI pepwheel swissprot:YGHG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGHG_ECOLI pepwindow swissprot:YGHG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGHG_ECOLI sigcleave swissprot:YGHG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGHG_ECOLI ## Database ID URL or Descriptions # CAUTION Could be the product of a pseudogene. It lacks the N- terminal part of the replication protein P. {ECO 0000305}. # EcoGene EG12350 peaD # GO_process GO:0006270 DNA replication initiation; IEA:InterPro. # GOslim_process GO:0006259 DNA metabolic process # IntAct P77528 2 # InterPro IPR009731 Phage_lambda_P # MISCELLANEOUS PEAD_ECOLI Encoded by the cryptic lambdoid prophage DLP12. # Organism PEAD_ECOLI Escherichia coli (strain K12) # Pfam PF06992 Phage_lambda_P # Proteomes UP000000625 Chromosome # RecName PEAD_ECOLI Putative uncharacterized protein PeaD # SIMILARITY Belongs to the phage P protein family. {ECO 0000305}. BLAST swissprot:PEAD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PEAD_ECOLI DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG12350 http://www.ecogene.org/geneInfo.php?eg_id=EG12350 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006270 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 HOGENOM HOG000202508 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000202508&db=HOGENOM6 IntAct P77528 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77528* InterPro IPR009731 http://www.ebi.ac.uk/interpro/entry/IPR009731 OMA MVTNLYQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MVTNLYQ PSORT swissprot:PEAD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PEAD_ECOLI PSORT-B swissprot:PEAD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PEAD_ECOLI PSORT2 swissprot:PEAD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PEAD_ECOLI Pfam PF06992 http://pfam.xfam.org/family/PF06992 Phobius swissprot:PEAD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PEAD_ECOLI ProteinModelPortal P77528 http://www.proteinmodelportal.org/query/uniprot/P77528 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 UniProtKB PEAD_ECOLI http://www.uniprot.org/uniprot/PEAD_ECOLI UniProtKB-AC P77528 http://www.uniprot.org/uniprot/P77528 charge swissprot:PEAD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PEAD_ECOLI epestfind swissprot:PEAD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PEAD_ECOLI garnier swissprot:PEAD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PEAD_ECOLI helixturnhelix swissprot:PEAD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PEAD_ECOLI hmoment swissprot:PEAD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PEAD_ECOLI iep swissprot:PEAD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PEAD_ECOLI inforesidue swissprot:PEAD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PEAD_ECOLI octanol swissprot:PEAD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PEAD_ECOLI pepcoil swissprot:PEAD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PEAD_ECOLI pepdigest swissprot:PEAD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PEAD_ECOLI pepinfo swissprot:PEAD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PEAD_ECOLI pepnet swissprot:PEAD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PEAD_ECOLI pepstats swissprot:PEAD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PEAD_ECOLI pepwheel swissprot:PEAD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PEAD_ECOLI pepwindow swissprot:PEAD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PEAD_ECOLI sigcleave swissprot:PEAD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PEAD_ECOLI ## Database ID URL or Descriptions # CAUTION There is no equivalent of this gene in strain K12 / MG1655. {ECO 0000305}. # FUNCTION INC11_ECOLI Involved in the transposition of the insertion sequence IS2. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 1.10.10.60 -; 1. # InterPro IPR002514 Transposase_8 # InterPro IPR009057 Homeodomain-like # Organism INC11_ECOLI Escherichia coli (strain K12) # Pfam PF01527 HTH_Tnp_1 # RecName INC11_ECOLI Transposase InsC for insertion element IS2-11 # RefSeq WP_000567766 NZ_LN832404.1 # SIMILARITY Belongs to the transposase 8 family. {ECO 0000305}. # SUPFAM SSF46689 SSF46689 # eggNOG COG2963 LUCA # eggNOG ENOG4108ZQS Bacteria BLAST swissprot:INC11_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INC11_ECOLI DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EnsemblBacteria BAE77578 http://www.ensemblgenomes.org/id/BAE77578 EnsemblBacteria BAE77578 http://www.ensemblgenomes.org/id/BAE77578 EnsemblBacteria BAE77578 http://www.ensemblgenomes.org/id/BAE77578 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 InterPro IPR002514 http://www.ebi.ac.uk/interpro/entry/IPR002514 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 KEGG_Gene ecj:JW5934 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5934 PSORT swissprot:INC11_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INC11_ECOLI PSORT-B swissprot:INC11_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INC11_ECOLI PSORT2 swissprot:INC11_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INC11_ECOLI Pfam PF01527 http://pfam.xfam.org/family/PF01527 Phobius swissprot:INC11_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INC11_ECOLI PhylomeDB P0CF50 http://phylomedb.org/?seqid=P0CF50 ProteinModelPortal P0CF50 http://www.proteinmodelportal.org/query/uniprot/P0CF50 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 RefSeq WP_000567766 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000567766 STRING 511145.b4272 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4272&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 UniProtKB INC11_ECOLI http://www.uniprot.org/uniprot/INC11_ECOLI UniProtKB-AC P0CF50 http://www.uniprot.org/uniprot/P0CF50 charge swissprot:INC11_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INC11_ECOLI eggNOG COG2963 http://eggnogapi.embl.de/nog_data/html/tree/COG2963 eggNOG ENOG4108ZQS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZQS epestfind swissprot:INC11_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INC11_ECOLI garnier swissprot:INC11_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INC11_ECOLI helixturnhelix swissprot:INC11_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INC11_ECOLI hmoment swissprot:INC11_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INC11_ECOLI iep swissprot:INC11_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INC11_ECOLI inforesidue swissprot:INC11_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INC11_ECOLI octanol swissprot:INC11_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INC11_ECOLI pepcoil swissprot:INC11_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INC11_ECOLI pepdigest swissprot:INC11_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INC11_ECOLI pepinfo swissprot:INC11_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INC11_ECOLI pepnet swissprot:INC11_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INC11_ECOLI pepstats swissprot:INC11_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INC11_ECOLI pepwheel swissprot:INC11_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INC11_ECOLI pepwindow swissprot:INC11_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INC11_ECOLI sigcleave swissprot:INC11_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INC11_ECOLI ## Database ID URL or Descriptions # AltName UIDR_ECOLI Gus operon repressor # AltName UIDR_ECOLI Uid operon repressor # BioGrid 4263484 19 # EcoGene EG12667 uidR # FUNCTION UIDR_ECOLI Repressor for the uidRABC (gusRABC) operon. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0000976 transcription regulatory region sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IBA:GO_Central. # GO_process GO:0006351 transcription, DNA-templated; IEP:EcoCyc. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.357.10 -; 1. # IntAct P0ACT6 11 # InterPro IPR001647 HTH_TetR # InterPro IPR009057 Homeodomain-like # InterPro IPR011075 Tet_transcr_reg_TetR-rel_C # InterPro IPR015893 Tet_transcr_reg_TetR-like_C # InterPro IPR023772 DNA-bd_HTH_TetR-type_CS # KEGG_Brite ko03000 Transcription factors # Organism UIDR_ECOLI Escherichia coli (strain K12) # PATRIC 32118538 VBIEscCol129921_1689 # PIR D64918 D64918 # PRINTS PR00455 HTHTETR # PROSITE PS01081 HTH_TETR_1 # PROSITE PS50977 HTH_TETR_2 # Pfam PF00440 TetR_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UIDR_ECOLI HTH-type transcriptional regulator UidR # RefSeq NP_416135 NC_000913.3 # RefSeq WP_000969092 NZ_LN832404.1 # SIMILARITY Contains 1 HTH tetR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00335}. # SUPFAM SSF46689 SSF46689 # SUPFAM SSF48498 SSF48498 # eggNOG COG1309 LUCA # eggNOG ENOG4105XEA Bacteria BLAST swissprot:UIDR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UIDR_ECOLI BioCyc ECOL316407:JW1610-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1610-MONOMER BioCyc EcoCyc:G6867-MONOMER http://biocyc.org/getid?id=EcoCyc:G6867-MONOMER COG COG1309 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1309 DIP DIP-48053N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48053N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M14641 http://www.ebi.ac.uk/ena/data/view/M14641 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2533 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2533 EcoGene EG12667 http://www.ecogene.org/geneInfo.php?eg_id=EG12667 EnsemblBacteria AAC74690 http://www.ensemblgenomes.org/id/AAC74690 EnsemblBacteria AAC74690 http://www.ensemblgenomes.org/id/AAC74690 EnsemblBacteria BAA15369 http://www.ensemblgenomes.org/id/BAA15369 EnsemblBacteria BAA15369 http://www.ensemblgenomes.org/id/BAA15369 EnsemblBacteria BAA15369 http://www.ensemblgenomes.org/id/BAA15369 EnsemblBacteria b1618 http://www.ensemblgenomes.org/id/b1618 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000976 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000976 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.357.10 http://www.cathdb.info/version/latest/superfamily/1.10.357.10 GeneID 946150 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946150 HOGENOM HOG000215576 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000215576&db=HOGENOM6 InParanoid P0ACT6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACT6 IntAct P0ACT6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACT6* InterPro IPR001647 http://www.ebi.ac.uk/interpro/entry/IPR001647 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR011075 http://www.ebi.ac.uk/interpro/entry/IPR011075 InterPro IPR015893 http://www.ebi.ac.uk/interpro/entry/IPR015893 InterPro IPR023772 http://www.ebi.ac.uk/interpro/entry/IPR023772 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW1610 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1610 KEGG_Gene eco:b1618 http://www.genome.jp/dbget-bin/www_bget?eco:b1618 KEGG_Orthology KO:K16138 http://www.genome.jp/dbget-bin/www_bget?KO:K16138 MINT MINT-1223157 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1223157 OMA ELATCCI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ELATCCI PRINTS PR00455 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00455 PROSITE PS01081 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01081 PROSITE PS50977 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50977 PSORT swissprot:UIDR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UIDR_ECOLI PSORT-B swissprot:UIDR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UIDR_ECOLI PSORT2 swissprot:UIDR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UIDR_ECOLI Pfam PF00440 http://pfam.xfam.org/family/PF00440 Phobius swissprot:UIDR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UIDR_ECOLI PhylomeDB P0ACT6 http://phylomedb.org/?seqid=P0ACT6 ProteinModelPortal P0ACT6 http://www.proteinmodelportal.org/query/uniprot/P0ACT6 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416135 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416135 RefSeq WP_000969092 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000969092 SMR P0ACT6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACT6 STRING 511145.b1618 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1618&targetmode=cogs STRING COG1309 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1309&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF48498 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48498 UniProtKB UIDR_ECOLI http://www.uniprot.org/uniprot/UIDR_ECOLI UniProtKB-AC P0ACT6 http://www.uniprot.org/uniprot/P0ACT6 charge swissprot:UIDR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UIDR_ECOLI eggNOG COG1309 http://eggnogapi.embl.de/nog_data/html/tree/COG1309 eggNOG ENOG4105XEA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105XEA epestfind swissprot:UIDR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UIDR_ECOLI garnier swissprot:UIDR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UIDR_ECOLI helixturnhelix swissprot:UIDR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UIDR_ECOLI hmoment swissprot:UIDR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UIDR_ECOLI iep swissprot:UIDR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UIDR_ECOLI inforesidue swissprot:UIDR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UIDR_ECOLI octanol swissprot:UIDR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UIDR_ECOLI pepcoil swissprot:UIDR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UIDR_ECOLI pepdigest swissprot:UIDR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UIDR_ECOLI pepinfo swissprot:UIDR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UIDR_ECOLI pepnet swissprot:UIDR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UIDR_ECOLI pepstats swissprot:UIDR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UIDR_ECOLI pepwheel swissprot:UIDR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UIDR_ECOLI pepwindow swissprot:UIDR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UIDR_ECOLI sigcleave swissprot:UIDR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UIDR_ECOLI ## Database ID URL or Descriptions # BioGrid 4263366 200 # CATALYTIC ACTIVITY SRMB_ECOLI ATP + H(2)O = ADP + phosphate. {ECO 0000255|HAMAP-Rule MF_00967, ECO 0000269|PubMed 15196029}. # DISRUPTION PHENOTYPE SRMB_ECOLI Cells lacking this gene grow very poorly at 20 degrees Celsius, show a severe deficit of free 50S ribosomal subunits and accumulate an abnormal large ribosomal subunit. Disruption also impairs the processing of both 23S and 16S rRNAs. {ECO 0000269|PubMed 12787353, ECO 0000269|PubMed 15148362}. # DOMAIN SRMB_ECOLI The C-terminal extension is not essential for ribosome assembly, but is important for the formation or the stability of the complex. {ECO 0000269|PubMed 19734346}. # EcoGene EG10975 srmB # FUNCTION SRMB_ECOLI DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit at low temperature. Exhibits RNA-stimulated ATP hydrolysis and RNA unwinding activity. Acts before DeaD. {ECO 0000255|HAMAP-Rule MF_00967, ECO 0000269|PubMed 12787353, ECO 0000269|PubMed 15148362, ECO 0000269|PubMed 15196029}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004004 ATP-dependent RNA helicase activity; IDA:UniProtKB. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008143 poly(A) binding; IDA:UniProtKB. # GO_function GO:0008186 RNA-dependent ATPase activity; IDA:UniProtKB. # GO_function GO:0033592 RNA strand annealing activity; IDA:EcoCyc. # GO_process GO:0000027 ribosomal large subunit assembly; IMP:EcoCyc. # GO_process GO:0010501 RNA secondary structure unwinding; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0004386 helicase activity # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0022618 ribonucleoprotein complex assembly # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.50.300 -; 2. # HAMAP MF_00967 DEAD_helicase_SrmB # INTERACTION SRMB_ECOLI P36979 rlmN; NbExp=3; IntAct=EBI-546628, EBI-559071; P37765 rluB; NbExp=4; IntAct=EBI-546628, EBI-561550; # IntAct P21507 33 # InterPro IPR000629 RNA-helicase_DEAD-box_CS # InterPro IPR001650 Helicase_C # InterPro IPR011545 DEAD/DEAH_box_helicase_dom # InterPro IPR014001 Helicase_ATP-bd # InterPro IPR014014 RNA_helicase_DEAD_Q_motif # InterPro IPR027417 P-loop_NTPase # InterPro IPR028621 DEAD_helicase_SrmB # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # MISCELLANEOUS Overexpression suppresses a mutant defective in 50S ribosomal subunit assembly. {ECO:0000305|PubMed 2461520}. # Organism SRMB_ECOLI Escherichia coli (strain K12) # PATRIC 32120551 VBIEscCol129921_2678 # PDB 2YJT X-ray; 2.90 A; D=219-388 # PIR G65035 G65035 # PROSITE PS00039 DEAD_ATP_HELICASE # PROSITE PS51192 HELICASE_ATP_BIND_1 # PROSITE PS51194 HELICASE_CTER # PROSITE PS51195 Q_MOTIF # Pfam PF00270 DEAD # Pfam PF00271 Helicase_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ATP-dependent RNA helicase SrmB {ECO:0000255|HAMAP-Rule MF_00967} # RefSeq NP_417071 NC_000913.3 # RefSeq WP_000219203 NZ_LN832404.1 # SIMILARITY Belongs to the DEAD box helicase family. SrmB subfamily. {ECO:0000255|HAMAP-Rule MF_00967}. # SIMILARITY Contains 1 helicase ATP-binding domain. {ECO:0000255|HAMAP-Rule MF_00967}. # SIMILARITY Contains 1 helicase C-terminal domain. {ECO:0000255|HAMAP-Rule MF_00967}. # SMART SM00487 DEXDc # SMART SM00490 HELICc # SUBCELLULAR LOCATION SRMB_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00967}. # SUBUNIT SRMB_ECOLI Interacts with the 50S ribosomal subunit. Forms a complex with the 50S ribosomal proteins L4 and L24, and a region near the 5'-end of 23S rRNA. {ECO 0000255|HAMAP-Rule MF_00967, ECO 0000269|PubMed 19734346}. # SUPFAM SSF52540 SSF52540 # eggNOG COG0513 LUCA # eggNOG ENOG4105C1J Bacteria BLAST swissprot:SRMB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SRMB_ECOLI BioCyc ECOL316407:JW2560-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2560-MONOMER BioCyc EcoCyc:EG10975-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10975-MONOMER COG COG0513 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0513 DIP DIP-10920N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10920N DOI 10.1021/bi049852s http://dx.doi.org/10.1021/bi049852s DOI 10.1038/336496a0 http://dx.doi.org/10.1038/336496a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2003.03513.x http://dx.doi.org/10.1046/j.1365-2958.2003.03513.x DOI 10.1093/nar/gkh603 http://dx.doi.org/10.1093/nar/gkh603 DOI 10.1093/nar/gkp685 http://dx.doi.org/10.1093/nar/gkp685 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.4.13 {ECO:0000255|HAMAP-Rule:MF_00967} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.4.13 {ECO:0000255|HAMAP-Rule:MF_00967} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D13169 http://www.ebi.ac.uk/ena/data/view/D13169 EMBL D64044 http://www.ebi.ac.uk/ena/data/view/D64044 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X14152 http://www.ebi.ac.uk/ena/data/view/X14152 ENZYME 3.6.4.13 {ECO:0000255|HAMAP-Rule:MF_00967} http://enzyme.expasy.org/EC/3.6.4.13 {ECO:0000255|HAMAP-Rule:MF_00967} EchoBASE EB0968 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0968 EcoGene EG10975 http://www.ecogene.org/geneInfo.php?eg_id=EG10975 EnsemblBacteria AAC75629 http://www.ensemblgenomes.org/id/AAC75629 EnsemblBacteria AAC75629 http://www.ensemblgenomes.org/id/AAC75629 EnsemblBacteria BAE76752 http://www.ensemblgenomes.org/id/BAE76752 EnsemblBacteria BAE76752 http://www.ensemblgenomes.org/id/BAE76752 EnsemblBacteria BAE76752 http://www.ensemblgenomes.org/id/BAE76752 EnsemblBacteria b2576 http://www.ensemblgenomes.org/id/b2576 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004004 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004004 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008143 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008143 GO_function GO:0008186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008186 GO_function GO:0033592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033592 GO_process GO:0000027 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000027 GO_process GO:0010501 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010501 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0004386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004386 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0022618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022618 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947055 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947055 HAMAP MF_00967 http://hamap.expasy.org/unirule/MF_00967 HOGENOM HOG000268807 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000268807&db=HOGENOM6 InParanoid P21507 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P21507 IntAct P21507 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P21507* IntEnz 3.6.4.13 {ECO:0000255|HAMAP-Rule:MF_00967} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.4.13 {ECO:0000255|HAMAP-Rule:MF_00967} InterPro IPR000629 http://www.ebi.ac.uk/interpro/entry/IPR000629 InterPro IPR001650 http://www.ebi.ac.uk/interpro/entry/IPR001650 InterPro IPR011545 http://www.ebi.ac.uk/interpro/entry/IPR011545 InterPro IPR014001 http://www.ebi.ac.uk/interpro/entry/IPR014001 InterPro IPR014014 http://www.ebi.ac.uk/interpro/entry/IPR014014 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR028621 http://www.ebi.ac.uk/interpro/entry/IPR028621 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW2560 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2560 KEGG_Gene eco:b2576 http://www.genome.jp/dbget-bin/www_bget?eco:b2576 KEGG_Orthology KO:K05590 http://www.genome.jp/dbget-bin/www_bget?KO:K05590 MINT MINT-1225512 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1225512 OMA PMMDRVA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PMMDRVA PDB 2YJT http://www.ebi.ac.uk/pdbe-srv/view/entry/2YJT PDBsum 2YJT http://www.ebi.ac.uk/pdbsum/2YJT PROSITE PS00039 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00039 PROSITE PS51192 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51192 PROSITE PS51194 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51194 PROSITE PS51195 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51195 PSORT swissprot:SRMB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SRMB_ECOLI PSORT-B swissprot:SRMB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SRMB_ECOLI PSORT2 swissprot:SRMB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SRMB_ECOLI Pfam PF00270 http://pfam.xfam.org/family/PF00270 Pfam PF00271 http://pfam.xfam.org/family/PF00271 Phobius swissprot:SRMB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SRMB_ECOLI PhylomeDB P21507 http://phylomedb.org/?seqid=P21507 ProteinModelPortal P21507 http://www.proteinmodelportal.org/query/uniprot/P21507 PubMed 12787353 http://www.ncbi.nlm.nih.gov/pubmed/12787353 PubMed 15148362 http://www.ncbi.nlm.nih.gov/pubmed/15148362 PubMed 15196029 http://www.ncbi.nlm.nih.gov/pubmed/15196029 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19734346 http://www.ncbi.nlm.nih.gov/pubmed/19734346 PubMed 2461520 http://www.ncbi.nlm.nih.gov/pubmed/2461520 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417071 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417071 RefSeq WP_000219203 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000219203 SMART SM00487 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00487 SMART SM00490 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00490 SMR P21507 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P21507 STRING 511145.b2576 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2576&targetmode=cogs STRING COG0513 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0513&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB SRMB_ECOLI http://www.uniprot.org/uniprot/SRMB_ECOLI UniProtKB-AC P21507 http://www.uniprot.org/uniprot/P21507 charge swissprot:SRMB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SRMB_ECOLI eggNOG COG0513 http://eggnogapi.embl.de/nog_data/html/tree/COG0513 eggNOG ENOG4105C1J http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C1J epestfind swissprot:SRMB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SRMB_ECOLI garnier swissprot:SRMB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SRMB_ECOLI helixturnhelix swissprot:SRMB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SRMB_ECOLI hmoment swissprot:SRMB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SRMB_ECOLI iep swissprot:SRMB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SRMB_ECOLI inforesidue swissprot:SRMB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SRMB_ECOLI octanol swissprot:SRMB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SRMB_ECOLI pepcoil swissprot:SRMB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SRMB_ECOLI pepdigest swissprot:SRMB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SRMB_ECOLI pepinfo swissprot:SRMB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SRMB_ECOLI pepnet swissprot:SRMB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SRMB_ECOLI pepstats swissprot:SRMB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SRMB_ECOLI pepwheel swissprot:SRMB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SRMB_ECOLI pepwindow swissprot:SRMB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SRMB_ECOLI sigcleave swissprot:SRMB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SRMB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260526 348 # CATALYTIC ACTIVITY Dimethylallyl phosphate + FMNH(2) = prenylated FMNH(2) + phosphate. {ECO:0000255|HAMAP-Rule MF_01984}. # DISRUPTION PHENOTYPE Cells lacking this gene produce very low levels of coenzyme Q(8) during logarithmic growth, grow slowly on succinate as the sole carbon source, accumulate 4-hydroxy-3- octaprenyl-benzoate, and have reduced UbiG O-methyltransferase activity. In contrast, they synthesize near normal levels of Q(8) in the stationary phase. {ECO:0000269|PubMed 17889824}. # EcoGene EG11044 ubiX # FUNCTION UBIX_ECOLI Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN (By similarity). Acts in concert with UbiD to perform the decarboxylation of 4-hydroxy-3-octaprenyl-benzoate, a step in the biosynthesis of coenzyme Q (PubMed 16923914, PubMed 17889824). {ECO 0000255|HAMAP-Rule MF_01984, ECO 0000269|PubMed 16923914, ECO 0000269|PubMed 17889824}. # GO_function GO:0004659 prenyltransferase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0008694 3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity; IGI:EcoCyc. # GO_process GO:0006744 ubiquinone biosynthetic process; IGI:EcoCyc. # GO_process GO:0009108 coenzyme biosynthetic process; IGI:EcoCyc. # GOslim_function GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.1950 -; 1. # HAMAP MF_01984 ubiX_pad # INDUCTION During aerobic growth, expression depends on the carbon source, with the highest expression on succinate, a median expression on glycerol, and the lowest on glucose. During anaerobic growth, glucose does not inhibit expression. {ECO:0000269|PubMed 12799002}. # IntAct P0AG03 6 # InterPro IPR003382 Flavoprotein # InterPro IPR004507 UbiX_Pad1 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00130 Ubiquinone and other terpenoid-quinone biosynthesis # Organism UBIX_ECOLI Escherichia coli (strain K12) # PATRIC 32119993 VBIEscCol129921_2406 # PIR E65003 XMECFD # Pfam PF02441 Flavoprotein # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Flavin prenyltransferase UbiX {ECO:0000255|HAMAP-Rule MF_01984} # RefSeq NP_416814 NC_000913.3 # RefSeq WP_000825700 NZ_LN832404.1 # SIMILARITY Belongs to the UbiX/PAD1 family. {ECO:0000255|HAMAP- Rule MF_01984}. # SUPFAM SSF52507 SSF52507 # TIGRFAMs TIGR00421 ubiX_pad # eggNOG COG0163 LUCA # eggNOG ENOG4108UMA Bacteria BLAST swissprot:UBIX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UBIX_ECOLI BioCyc ECOL316407:JW2308-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2308-MONOMER BioCyc EcoCyc:UBIX-MONOMER http://biocyc.org/getid?id=EcoCyc:UBIX-MONOMER COG COG0163 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0163 DIP DIP-47873N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47873N DOI 10.1016/S0378-1097(03)00343-4 http://dx.doi.org/10.1016/S0378-1097(03)00343-4 DOI 10.1016/j.abb.2007.08.009 http://dx.doi.org/10.1016/j.abb.2007.08.009 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00668-06 http://dx.doi.org/10.1128/JB.00668-06 EC_number EC:2.5.1.129 {ECO:0000255|HAMAP-Rule:MF_01984} http://www.genome.jp/dbget-bin/www_bget?EC:2.5.1.129 {ECO:0000255|HAMAP-Rule:MF_01984} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M68935 http://www.ebi.ac.uk/ena/data/view/M68935 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.5.1.129 {ECO:0000255|HAMAP-Rule:MF_01984} http://enzyme.expasy.org/EC/2.5.1.129 {ECO:0000255|HAMAP-Rule:MF_01984} EchoBASE EB1037 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1037 EcoGene EG11044 http://www.ecogene.org/geneInfo.php?eg_id=EG11044 EnsemblBacteria AAC75371 http://www.ensemblgenomes.org/id/AAC75371 EnsemblBacteria AAC75371 http://www.ensemblgenomes.org/id/AAC75371 EnsemblBacteria BAA16157 http://www.ensemblgenomes.org/id/BAA16157 EnsemblBacteria BAA16157 http://www.ensemblgenomes.org/id/BAA16157 EnsemblBacteria BAA16157 http://www.ensemblgenomes.org/id/BAA16157 EnsemblBacteria b2311 http://www.ensemblgenomes.org/id/b2311 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004659 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004659 GO_function GO:0008694 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008694 GO_process GO:0006744 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006744 GO_process GO:0009108 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009108 GOslim_function GO:0016765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016765 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.1950 http://www.cathdb.info/version/latest/superfamily/3.40.50.1950 GeneID 949033 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949033 HAMAP MF_01984 http://hamap.expasy.org/unirule/MF_01984 HOGENOM HOG000225437 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000225437&db=HOGENOM6 InParanoid P0AG03 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AG03 IntAct P0AG03 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AG03* IntEnz 2.5.1.129 {ECO:0000255|HAMAP-Rule:MF_01984} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.5.1.129 {ECO:0000255|HAMAP-Rule:MF_01984} InterPro IPR003382 http://www.ebi.ac.uk/interpro/entry/IPR003382 InterPro IPR004507 http://www.ebi.ac.uk/interpro/entry/IPR004507 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2308 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2308 KEGG_Gene eco:b2311 http://www.genome.jp/dbget-bin/www_bget?eco:b2311 KEGG_Orthology KO:K03186 http://www.genome.jp/dbget-bin/www_bget?KO:K03186 KEGG_Pathway ko00130 http://www.genome.jp/kegg-bin/show_pathway?ko00130 KEGG_Reaction rn:R04985 http://www.genome.jp/dbget-bin/www_bget?rn:R04985 KEGG_Reaction rn:R04986 http://www.genome.jp/dbget-bin/www_bget?rn:R04986 MINT MINT-1239757 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1239757 OMA IIMPREM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IIMPREM PSORT swissprot:UBIX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UBIX_ECOLI PSORT-B swissprot:UBIX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UBIX_ECOLI PSORT2 swissprot:UBIX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UBIX_ECOLI Pfam PF02441 http://pfam.xfam.org/family/PF02441 Phobius swissprot:UBIX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UBIX_ECOLI PhylomeDB P0AG03 http://phylomedb.org/?seqid=P0AG03 ProteinModelPortal P0AG03 http://www.proteinmodelportal.org/query/uniprot/P0AG03 PubMed 12799002 http://www.ncbi.nlm.nih.gov/pubmed/12799002 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16923914 http://www.ncbi.nlm.nih.gov/pubmed/16923914 PubMed 17889824 http://www.ncbi.nlm.nih.gov/pubmed/17889824 PubMed 3040734 http://www.ncbi.nlm.nih.gov/pubmed/3040734 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416814 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416814 RefSeq WP_000825700 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000825700 SMR P0AG03 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AG03 STRING 511145.b2311 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2311&targetmode=cogs STRING COG0163 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0163&targetmode=cogs SUPFAM SSF52507 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52507 TIGRFAMs TIGR00421 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00421 UniProtKB UBIX_ECOLI http://www.uniprot.org/uniprot/UBIX_ECOLI UniProtKB-AC P0AG03 http://www.uniprot.org/uniprot/P0AG03 charge swissprot:UBIX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UBIX_ECOLI eggNOG COG0163 http://eggnogapi.embl.de/nog_data/html/tree/COG0163 eggNOG ENOG4108UMA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UMA epestfind swissprot:UBIX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UBIX_ECOLI garnier swissprot:UBIX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UBIX_ECOLI helixturnhelix swissprot:UBIX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UBIX_ECOLI hmoment swissprot:UBIX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UBIX_ECOLI iep swissprot:UBIX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UBIX_ECOLI inforesidue swissprot:UBIX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UBIX_ECOLI octanol swissprot:UBIX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UBIX_ECOLI pepcoil swissprot:UBIX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UBIX_ECOLI pepdigest swissprot:UBIX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UBIX_ECOLI pepinfo swissprot:UBIX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UBIX_ECOLI pepnet swissprot:UBIX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UBIX_ECOLI pepstats swissprot:UBIX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UBIX_ECOLI pepwheel swissprot:UBIX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UBIX_ECOLI pepwindow swissprot:UBIX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UBIX_ECOLI sigcleave swissprot:UBIX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UBIX_ECOLI ## Database ID URL or Descriptions # BioGrid 4260081 6 # EcoGene EG13448 ymfD # Gene3D 3.40.50.150 -; 1. # IntAct P75967 3 # InterPro IPR029063 SAM-dependent_MTases # Organism YMFD_ECOLI Escherichia coli (strain K12) # PIR F64858 F64858 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YMFD_ECOLI Uncharacterized protein YmfD # RefSeq NP_415655 NC_000913.3 # RefSeq WP_000241967 NZ_CP010440.1 # SUPFAM SSF53335 SSF53335 # eggNOG ENOG4106JA9 Bacteria # eggNOG ENOG410YCU8 LUCA BLAST swissprot:YMFD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YMFD_ECOLI BioCyc ECOL316407:JW1123-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1123-MONOMER BioCyc EcoCyc:G6582-MONOMER http://biocyc.org/getid?id=EcoCyc:G6582-MONOMER DIP DIP-12717N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12717N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3222 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3222 EcoGene EG13448 http://www.ecogene.org/geneInfo.php?eg_id=EG13448 EnsemblBacteria AAC74221 http://www.ensemblgenomes.org/id/AAC74221 EnsemblBacteria AAC74221 http://www.ensemblgenomes.org/id/AAC74221 EnsemblBacteria BAE76375 http://www.ensemblgenomes.org/id/BAE76375 EnsemblBacteria BAE76375 http://www.ensemblgenomes.org/id/BAE76375 EnsemblBacteria BAE76375 http://www.ensemblgenomes.org/id/BAE76375 EnsemblBacteria b1137 http://www.ensemblgenomes.org/id/b1137 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 GeneID 945329 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945329 HOGENOM HOG000294615 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000294615&db=HOGENOM6 InParanoid P75967 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75967 IntAct P75967 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75967* InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 KEGG_Gene ecj:JW1123 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1123 KEGG_Gene eco:b1137 http://www.genome.jp/dbget-bin/www_bget?eco:b1137 OMA DFILCAN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DFILCAN PSORT swissprot:YMFD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YMFD_ECOLI PSORT-B swissprot:YMFD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YMFD_ECOLI PSORT2 swissprot:YMFD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YMFD_ECOLI Phobius swissprot:YMFD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YMFD_ECOLI ProteinModelPortal P75967 http://www.proteinmodelportal.org/query/uniprot/P75967 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415655 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415655 RefSeq WP_000241967 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000241967 STRING 511145.b1137 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1137&targetmode=cogs SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 UniProtKB YMFD_ECOLI http://www.uniprot.org/uniprot/YMFD_ECOLI UniProtKB-AC P75967 http://www.uniprot.org/uniprot/P75967 charge swissprot:YMFD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YMFD_ECOLI eggNOG ENOG4106JA9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106JA9 eggNOG ENOG410YCU8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YCU8 epestfind swissprot:YMFD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YMFD_ECOLI garnier swissprot:YMFD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YMFD_ECOLI helixturnhelix swissprot:YMFD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YMFD_ECOLI hmoment swissprot:YMFD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YMFD_ECOLI iep swissprot:YMFD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YMFD_ECOLI inforesidue swissprot:YMFD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YMFD_ECOLI octanol swissprot:YMFD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YMFD_ECOLI pepcoil swissprot:YMFD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YMFD_ECOLI pepdigest swissprot:YMFD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YMFD_ECOLI pepinfo swissprot:YMFD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YMFD_ECOLI pepnet swissprot:YMFD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YMFD_ECOLI pepstats swissprot:YMFD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YMFD_ECOLI pepwheel swissprot:YMFD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YMFD_ECOLI pepwindow swissprot:YMFD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YMFD_ECOLI sigcleave swissprot:YMFD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YMFD_ECOLI ## Database ID URL or Descriptions # BioGrid 4263489 136 # EcoGene EG11488 mliC # FUNCTION MLIC_ECOLI Specifically inhibits C-type lysozymes. {ECO 0000269|PubMed 18369469}. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_function GO:0060241 lysozyme inhibitor activity; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0030234 enzyme regulator activity # IntAct P28224 5 # InterPro IPR018660 C-type_lysozyme_inhibitor # Organism MLIC_ECOLI Escherichia coli (strain K12) # PATRIC 32118580 VBIEscCol129921_1710 # PDB 2F09 NMR; -; A=28-109 # PIR A43261 A43261 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF09864 MliC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Membrane-bound lysozyme inhibitor of C-type lysozyme {ECO:0000303|PubMed 18369469} # RefSeq NP_416156 NC_000913.3 # RefSeq WP_000178044 NZ_LN832404.1 # SIMILARITY Belongs to the MliC family. Type 1 subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION MLIC_ECOLI Cell outer membrane {ECO 0000269|PubMed 18369469}; Lipid-anchor {ECO 0000255|PROSITE- ProRule PRU00303, ECO 0000269|PubMed 18369469}. Note=Anchored to the periplasmic side. {ECO 0000269|PubMed 18369469}. # SUBUNIT Monomer. {ECO:0000269|PubMed 16937244}. # SUPFAM SSF141488 SSF141488 # eggNOG COG3895 LUCA # eggNOG ENOG410642K Bacteria BLAST swissprot:MLIC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MLIC_ECOLI BioCyc ECOL316407:JW1631-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1631-MONOMER BioCyc EcoCyc:EG11488-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11488-MONOMER DIP DIP-11726N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11726N DOI 10.1007/s10858-006-9032-y http://dx.doi.org/10.1007/s10858-006-9032-y DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.ppat.1000019 http://dx.doi.org/10.1371/journal.ppat.1000019 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M92351 http://www.ebi.ac.uk/ena/data/view/M92351 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1451 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1451 EcoGene EG11488 http://www.ecogene.org/geneInfo.php?eg_id=EG11488 EnsemblBacteria AAC74711 http://www.ensemblgenomes.org/id/AAC74711 EnsemblBacteria AAC74711 http://www.ensemblgenomes.org/id/AAC74711 EnsemblBacteria BAA15400 http://www.ensemblgenomes.org/id/BAA15400 EnsemblBacteria BAA15400 http://www.ensemblgenomes.org/id/BAA15400 EnsemblBacteria BAA15400 http://www.ensemblgenomes.org/id/BAA15400 EnsemblBacteria b1639 http://www.ensemblgenomes.org/id/b1639 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_function GO:0060241 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060241 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 GeneID 946811 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946811 HOGENOM HOG000272969 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000272969&db=HOGENOM6 InParanoid P28224 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P28224 IntAct P28224 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P28224* InterPro IPR018660 http://www.ebi.ac.uk/interpro/entry/IPR018660 KEGG_Gene ecj:JW1631 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1631 KEGG_Gene eco:b1639 http://www.genome.jp/dbget-bin/www_bget?eco:b1639 OMA EYRCDEK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EYRCDEK PDB 2F09 http://www.ebi.ac.uk/pdbe-srv/view/entry/2F09 PDBsum 2F09 http://www.ebi.ac.uk/pdbsum/2F09 PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:MLIC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MLIC_ECOLI PSORT-B swissprot:MLIC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MLIC_ECOLI PSORT2 swissprot:MLIC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MLIC_ECOLI Pfam PF09864 http://pfam.xfam.org/family/PF09864 Phobius swissprot:MLIC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MLIC_ECOLI ProteinModelPortal P28224 http://www.proteinmodelportal.org/query/uniprot/P28224 PubMed 1356963 http://www.ncbi.nlm.nih.gov/pubmed/1356963 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16937244 http://www.ncbi.nlm.nih.gov/pubmed/16937244 PubMed 18369469 http://www.ncbi.nlm.nih.gov/pubmed/18369469 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416156 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416156 RefSeq WP_000178044 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000178044 SMR P28224 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P28224 STRING 511145.b1639 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1639&targetmode=cogs SUPFAM SSF141488 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF141488 UniProtKB MLIC_ECOLI http://www.uniprot.org/uniprot/MLIC_ECOLI UniProtKB-AC P28224 http://www.uniprot.org/uniprot/P28224 charge swissprot:MLIC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MLIC_ECOLI eggNOG COG3895 http://eggnogapi.embl.de/nog_data/html/tree/COG3895 eggNOG ENOG410642K http://eggnogapi.embl.de/nog_data/html/tree/ENOG410642K epestfind swissprot:MLIC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MLIC_ECOLI garnier swissprot:MLIC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MLIC_ECOLI helixturnhelix swissprot:MLIC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MLIC_ECOLI hmoment swissprot:MLIC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MLIC_ECOLI iep swissprot:MLIC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MLIC_ECOLI inforesidue swissprot:MLIC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MLIC_ECOLI octanol swissprot:MLIC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MLIC_ECOLI pepcoil swissprot:MLIC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MLIC_ECOLI pepdigest swissprot:MLIC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MLIC_ECOLI pepinfo swissprot:MLIC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MLIC_ECOLI pepnet swissprot:MLIC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MLIC_ECOLI pepstats swissprot:MLIC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MLIC_ECOLI pepwheel swissprot:MLIC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MLIC_ECOLI pepwindow swissprot:MLIC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MLIC_ECOLI sigcleave swissprot:MLIC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MLIC_ECOLI ## Database ID URL or Descriptions # BioGrid 4262697 9 # EcoGene EG12482 yjeT # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR019201 DUF2065 # Organism YJET_ECOLI Escherichia coli (strain K12) # PATRIC 32123925 VBIEscCol129921_4307 # PIR S56401 S56401 # Pfam PF09838 DUF2065 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJET_ECOLI Uncharacterized protein YjeT # RefSeq NP_418597 NC_000913.3 # RefSeq WP_001089295 NZ_LN832404.1 # SUBCELLULAR LOCATION YJET_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # eggNOG COG3242 LUCA BLAST swissprot:YJET_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJET_ECOLI BioCyc ECOL316407:JW4134-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4134-MONOMER BioCyc EcoCyc:G7844-MONOMER http://biocyc.org/getid?id=EcoCyc:G7844-MONOMER COG COG3242 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3242 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2375 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2375 EcoGene EG12482 http://www.ecogene.org/geneInfo.php?eg_id=EG12482 EnsemblBacteria AAC77133 http://www.ensemblgenomes.org/id/AAC77133 EnsemblBacteria AAC77133 http://www.ensemblgenomes.org/id/AAC77133 EnsemblBacteria BAE78177 http://www.ensemblgenomes.org/id/BAE78177 EnsemblBacteria BAE78177 http://www.ensemblgenomes.org/id/BAE78177 EnsemblBacteria BAE78177 http://www.ensemblgenomes.org/id/BAE78177 EnsemblBacteria b4176 http://www.ensemblgenomes.org/id/b4176 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 948696 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948696 HOGENOM HOG000272722 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000272722&db=HOGENOM6 IntAct P0AF73 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AF73* InterPro IPR019201 http://www.ebi.ac.uk/interpro/entry/IPR019201 KEGG_Gene ecj:JW4134 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4134 KEGG_Gene eco:b4176 http://www.genome.jp/dbget-bin/www_bget?eco:b4176 KEGG_Orthology KO:K09937 http://www.genome.jp/dbget-bin/www_bget?KO:K09937 OMA NRWRAYL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NRWRAYL PSORT swissprot:YJET_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJET_ECOLI PSORT-B swissprot:YJET_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJET_ECOLI PSORT2 swissprot:YJET_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJET_ECOLI Pfam PF09838 http://pfam.xfam.org/family/PF09838 Phobius swissprot:YJET_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJET_ECOLI ProteinModelPortal P0AF73 http://www.proteinmodelportal.org/query/uniprot/P0AF73 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418597 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418597 RefSeq WP_001089295 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001089295 STRING 511145.b4176 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4176&targetmode=cogs STRING COG3242 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3242&targetmode=cogs UniProtKB YJET_ECOLI http://www.uniprot.org/uniprot/YJET_ECOLI UniProtKB-AC P0AF73 http://www.uniprot.org/uniprot/P0AF73 charge swissprot:YJET_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJET_ECOLI eggNOG COG3242 http://eggnogapi.embl.de/nog_data/html/tree/COG3242 epestfind swissprot:YJET_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJET_ECOLI garnier swissprot:YJET_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJET_ECOLI helixturnhelix swissprot:YJET_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJET_ECOLI hmoment swissprot:YJET_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJET_ECOLI iep swissprot:YJET_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJET_ECOLI inforesidue swissprot:YJET_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJET_ECOLI octanol swissprot:YJET_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJET_ECOLI pepcoil swissprot:YJET_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJET_ECOLI pepdigest swissprot:YJET_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJET_ECOLI pepinfo swissprot:YJET_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJET_ECOLI pepnet swissprot:YJET_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJET_ECOLI pepstats swissprot:YJET_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJET_ECOLI pepwheel swissprot:YJET_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJET_ECOLI pepwindow swissprot:YJET_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJET_ECOLI sigcleave swissprot:YJET_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJET_ECOLI ## Database ID URL or Descriptions # AltName FLK_ECOLI Fluke # BioGrid 4263217 44 # EcoGene EG10229 flk # FUNCTION FLK_ECOLI Acts as a regulator of flagellar gene expression by modulating the protein level of the anti sigma factor FlgM upon sensing ring completion or hook elongation. Flk could inhibit FlgM secretion by acting as a braking system for the flagellar- associated type III secretion (T3S) system. Plays a role in hindering to flip the flagellar T3S specificity switch from the rod and hook-type substrates to filament-type substrates prior to hook-basal body (HBB) completion possibly by preventing interaction of FliK with FlhB (By similarity). {ECO 0000250}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0010468 regulation of gene expression; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0008150 biological_process # IntAct P15286 4 # InterPro IPR023597 Flagellar_regulator_Flk # Organism FLK_ECOLI Escherichia coli (strain K12) # PATRIC 32120015 VBIEscCol129921_2417 # PIR G65004 G65004 # PIRSF PIRSF020588 Flk # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FLK_ECOLI Flagellar regulator flk # RefSeq NP_416824 NC_000913.3 # RefSeq WP_000615834 NZ_LN832404.1 # SIMILARITY Belongs to the flk family. {ECO 0000305}. # SUBCELLULAR LOCATION FLK_ECOLI Cell inner membrane {ECO 0000305}; Single- pass membrane protein {ECO 0000305}. # eggNOG ENOG4106WZ1 Bacteria # eggNOG ENOG410YMCE LUCA BLAST swissprot:FLK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLK_ECOLI BioCyc ECOL316407:JW2318-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2318-MONOMER BioCyc EcoCyc:EG10229-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10229-MONOMER DIP DIP-9448N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9448N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M29962 http://www.ebi.ac.uk/ena/data/view/M29962 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U76961 http://www.ebi.ac.uk/ena/data/view/U76961 EchoBASE EB0225 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0225 EcoGene EG10229 http://www.ecogene.org/geneInfo.php?eg_id=EG10229 EnsemblBacteria AAC75381 http://www.ensemblgenomes.org/id/AAC75381 EnsemblBacteria AAC75381 http://www.ensemblgenomes.org/id/AAC75381 EnsemblBacteria BAA16178 http://www.ensemblgenomes.org/id/BAA16178 EnsemblBacteria BAA16178 http://www.ensemblgenomes.org/id/BAA16178 EnsemblBacteria BAA16178 http://www.ensemblgenomes.org/id/BAA16178 EnsemblBacteria b2321 http://www.ensemblgenomes.org/id/b2321 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0010468 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010468 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 946776 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946776 HOGENOM HOG000122477 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122477&db=HOGENOM6 IntAct P15286 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P15286* InterPro IPR023597 http://www.ebi.ac.uk/interpro/entry/IPR023597 KEGG_Gene ecj:JW2318 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2318 KEGG_Gene eco:b2321 http://www.genome.jp/dbget-bin/www_bget?eco:b2321 OMA FTHLVTW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FTHLVTW PSORT swissprot:FLK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLK_ECOLI PSORT-B swissprot:FLK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLK_ECOLI PSORT2 swissprot:FLK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLK_ECOLI Phobius swissprot:FLK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLK_ECOLI ProteinModelPortal P15286 http://www.proteinmodelportal.org/query/uniprot/P15286 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2681152 http://www.ncbi.nlm.nih.gov/pubmed/2681152 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416824 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416824 RefSeq WP_000615834 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000615834 STRING 511145.b2321 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2321&targetmode=cogs UniProtKB FLK_ECOLI http://www.uniprot.org/uniprot/FLK_ECOLI UniProtKB-AC P15286 http://www.uniprot.org/uniprot/P15286 charge swissprot:FLK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLK_ECOLI eggNOG ENOG4106WZ1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106WZ1 eggNOG ENOG410YMCE http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YMCE epestfind swissprot:FLK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLK_ECOLI garnier swissprot:FLK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLK_ECOLI helixturnhelix swissprot:FLK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLK_ECOLI hmoment swissprot:FLK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLK_ECOLI iep swissprot:FLK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLK_ECOLI inforesidue swissprot:FLK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLK_ECOLI octanol swissprot:FLK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLK_ECOLI pepcoil swissprot:FLK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLK_ECOLI pepdigest swissprot:FLK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLK_ECOLI pepinfo swissprot:FLK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLK_ECOLI pepnet swissprot:FLK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLK_ECOLI pepstats swissprot:FLK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLK_ECOLI pepwheel swissprot:FLK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLK_ECOLI pepwindow swissprot:FLK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLK_ECOLI sigcleave swissprot:FLK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLK_ECOLI ## Database ID URL or Descriptions # BioGrid 4263051 43 # EcoGene EG13335 yafW # FUNCTION YAFW_ECOLI Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the YkfI toxin. It does not seem to bind to the cognate toxin but instead induces toxin loss by an unknown mechanism. {ECO 0000269|PubMed 14594833}. # InterPro IPR009320 YagB_YeeU_YfjZ # Organism YAFW_ECOLI Escherichia coli (strain K12) # PATRIC 32115607 VBIEscCol129921_0247 # PIR F64749 F64749 # Pfam PF06154 CbeA_antitoxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAFW_ECOLI Antitoxin YafW # RefSeq NP_414780 NC_000913.3 # RefSeq WP_000070395 NZ_LN832404.1 # SIMILARITY Belongs to the CbeA/YafW/YfjZ antitoxin family. {ECO 0000305}. BLAST swissprot:YAFW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAFW_ECOLI BioCyc ECOL316407:JW0235-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0235-MONOMER BioCyc EcoCyc:G6121-MONOMER http://biocyc.org/getid?id=EcoCyc:G6121-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.185.22.6600-6608.2003 http://dx.doi.org/10.1128/JB.185.22.6600-6608.2003 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EchoBASE EB3119 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3119 EcoGene EG13335 http://www.ecogene.org/geneInfo.php?eg_id=EG13335 EnsemblBacteria AAC73349 http://www.ensemblgenomes.org/id/AAC73349 EnsemblBacteria AAC73349 http://www.ensemblgenomes.org/id/AAC73349 EnsemblBacteria BAA77914 http://www.ensemblgenomes.org/id/BAA77914 EnsemblBacteria BAA77914 http://www.ensemblgenomes.org/id/BAA77914 EnsemblBacteria BAA77914 http://www.ensemblgenomes.org/id/BAA77914 EnsemblBacteria b0246 http://www.ensemblgenomes.org/id/b0246 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 944929 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944929 HOGENOM HOG000290944 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000290944&db=HOGENOM6 InterPro IPR009320 http://www.ebi.ac.uk/interpro/entry/IPR009320 KEGG_Gene ecj:JW0235 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0235 KEGG_Gene eco:b0246 http://www.genome.jp/dbget-bin/www_bget?eco:b0246 PSORT swissprot:YAFW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAFW_ECOLI PSORT-B swissprot:YAFW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAFW_ECOLI PSORT2 swissprot:YAFW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAFW_ECOLI Pfam PF06154 http://pfam.xfam.org/family/PF06154 Phobius swissprot:YAFW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAFW_ECOLI PhylomeDB Q47684 http://phylomedb.org/?seqid=Q47684 ProteinModelPortal Q47684 http://www.proteinmodelportal.org/query/uniprot/Q47684 PubMed 14594833 http://www.ncbi.nlm.nih.gov/pubmed/14594833 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414780 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414780 RefSeq WP_000070395 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000070395 SMR Q47684 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q47684 STRING 511145.b0246 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0246&targetmode=cogs UniProtKB YAFW_ECOLI http://www.uniprot.org/uniprot/YAFW_ECOLI UniProtKB-AC Q47684 http://www.uniprot.org/uniprot/Q47684 charge swissprot:YAFW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAFW_ECOLI epestfind swissprot:YAFW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAFW_ECOLI garnier swissprot:YAFW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAFW_ECOLI helixturnhelix swissprot:YAFW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAFW_ECOLI hmoment swissprot:YAFW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAFW_ECOLI iep swissprot:YAFW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAFW_ECOLI inforesidue swissprot:YAFW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAFW_ECOLI octanol swissprot:YAFW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAFW_ECOLI pepcoil swissprot:YAFW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAFW_ECOLI pepdigest swissprot:YAFW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAFW_ECOLI pepinfo swissprot:YAFW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAFW_ECOLI pepnet swissprot:YAFW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAFW_ECOLI pepstats swissprot:YAFW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAFW_ECOLI pepwheel swissprot:YAFW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAFW_ECOLI pepwindow swissprot:YAFW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAFW_ECOLI sigcleave swissprot:YAFW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAFW_ECOLI ## Database ID URL or Descriptions # BioGrid 4259313 4 # CDD cd06309 PBP1_YtfQ_like # EcoGene EG12517 ytfQ # GO_component GO:0005886 plasma membrane; IBA:GO_Central. # GO_component GO:0016021 integral component of membrane; IBA:GO_Central. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0005534 galactose binding; IDA:EcoCyc. # GO_function GO:0015145 monosaccharide transmembrane transporter activity; IBA:GO_Central. # GO_process GO:0015757 galactose transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # IntAct P39325 8 # InterPro IPR025997 SBP_2_dom # InterPro IPR028082 Peripla_BP_I # InterPro IPR033893 ABC_YtfQ # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00221 Putative simple sugar transport system # KEGG_Brite ko02000 Transporters # Organism YTFQ_ECOLI Escherichia coli (strain K12) # PATRIC 32124029 VBIEscCol129921_4359 # PDB 2VK2 X-ray; 1.20 A; A=22-318 # PIR S56453 S56453 # Pfam PF13407 Peripla_BP_4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YTFQ_ECOLI ABC transporter periplasmic-binding protein YtfQ # RefSeq NP_418648 NC_000913.3 # RefSeq WP_000265913 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial solute-binding protein 2 family. {ECO 0000305}. # SUBCELLULAR LOCATION YTFQ_ECOLI Periplasm. # SUPFAM SSF53822 SSF53822 # TCDB 3.A.1.2.25 the atp-binding cassette (abc) superfamily # eggNOG ENOG4107R5U Bacteria # eggNOG ENOG410XPC7 LUCA BLAST swissprot:YTFQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YTFQ_ECOLI BioCyc ECOL316407:JW4186-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4186-MONOMER BioCyc EcoCyc:YTFQ-MONOMER http://biocyc.org/getid?id=EcoCyc:YTFQ-MONOMER BioCyc MetaCyc:YTFQ-MONOMER http://biocyc.org/getid?id=MetaCyc:YTFQ-MONOMER COG COG1879 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1879 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2409 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2409 EcoGene EG12517 http://www.ecogene.org/geneInfo.php?eg_id=EG12517 EnsemblBacteria AAC77184 http://www.ensemblgenomes.org/id/AAC77184 EnsemblBacteria AAC77184 http://www.ensemblgenomes.org/id/AAC77184 EnsemblBacteria BAE78228 http://www.ensemblgenomes.org/id/BAE78228 EnsemblBacteria BAE78228 http://www.ensemblgenomes.org/id/BAE78228 EnsemblBacteria BAE78228 http://www.ensemblgenomes.org/id/BAE78228 EnsemblBacteria b4227 http://www.ensemblgenomes.org/id/b4227 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0005534 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005534 GO_function GO:0015145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015145 GO_process GO:0015757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015757 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948746 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948746 HOGENOM HOG000212345 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000212345&db=HOGENOM6 InParanoid P39325 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39325 IntAct P39325 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39325* InterPro IPR025997 http://www.ebi.ac.uk/interpro/entry/IPR025997 InterPro IPR028082 http://www.ebi.ac.uk/interpro/entry/IPR028082 InterPro IPR033893 http://www.ebi.ac.uk/interpro/entry/IPR033893 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW4186 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4186 KEGG_Gene eco:b4227 http://www.genome.jp/dbget-bin/www_bget?eco:b4227 KEGG_Orthology KO:K02058 http://www.genome.jp/dbget-bin/www_bget?KO:K02058 OMA NERNEGW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NERNEGW PDB 2VK2 http://www.ebi.ac.uk/pdbe-srv/view/entry/2VK2 PDBsum 2VK2 http://www.ebi.ac.uk/pdbsum/2VK2 PSORT swissprot:YTFQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YTFQ_ECOLI PSORT-B swissprot:YTFQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YTFQ_ECOLI PSORT2 swissprot:YTFQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YTFQ_ECOLI Pfam PF13407 http://pfam.xfam.org/family/PF13407 Phobius swissprot:YTFQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YTFQ_ECOLI PhylomeDB P39325 http://phylomedb.org/?seqid=P39325 ProteinModelPortal P39325 http://www.proteinmodelportal.org/query/uniprot/P39325 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_418648 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418648 RefSeq WP_000265913 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000265913 SMR P39325 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39325 STRING 511145.b4227 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4227&targetmode=cogs STRING COG1879 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1879&targetmode=cogs SUPFAM SSF53822 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822 TCDB 3.A.1.2.25 http://www.tcdb.org/search/result.php?tc=3.A.1.2.25 UniProtKB YTFQ_ECOLI http://www.uniprot.org/uniprot/YTFQ_ECOLI UniProtKB-AC P39325 http://www.uniprot.org/uniprot/P39325 charge swissprot:YTFQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YTFQ_ECOLI eggNOG ENOG4107R5U http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107R5U eggNOG ENOG410XPC7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPC7 epestfind swissprot:YTFQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YTFQ_ECOLI garnier swissprot:YTFQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YTFQ_ECOLI helixturnhelix swissprot:YTFQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YTFQ_ECOLI hmoment swissprot:YTFQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YTFQ_ECOLI iep swissprot:YTFQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YTFQ_ECOLI inforesidue swissprot:YTFQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YTFQ_ECOLI octanol swissprot:YTFQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YTFQ_ECOLI pepcoil swissprot:YTFQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YTFQ_ECOLI pepdigest swissprot:YTFQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YTFQ_ECOLI pepinfo swissprot:YTFQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YTFQ_ECOLI pepnet swissprot:YTFQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YTFQ_ECOLI pepstats swissprot:YTFQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YTFQ_ECOLI pepwheel swissprot:YTFQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YTFQ_ECOLI pepwindow swissprot:YTFQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YTFQ_ECOLI sigcleave swissprot:YTFQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YTFQ_ECOLI ## Database ID URL or Descriptions # FUNCTION TRAV_ECOLI Involved in F pilus assembly. Appear to facilitate the polymerization of inner membrane-located pilin subunits into extracellular F pilus filaments. # GO_component GO:0009279 cell outer membrane; IEA:UniProtKB-SubCell. # GO_process GO:0000746 conjugation; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0008150 biological_process # InterPro IPR014118 T4SS_TraV # Organism TRAV_ECOLI Escherichia coli (strain K12) # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF09676 TraV # RecName TRAV_ECOLI Protein TraV # RefSeq NP_061461 NC_002483.1 # RefSeq WP_010892541 NZ_CP014273.1 # SUBCELLULAR LOCATION TRAV_ECOLI Cell outer membrane; Lipid-anchor. # TIGRFAMs TIGR02747 TraV BLAST swissprot:TRAV_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRAV_ECOLI DIP DIP-16927N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-16927N EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL U01159 http://www.ebi.ac.uk/ena/data/view/U01159 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_process GO:0000746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000746 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 1263566 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263566 InterPro IPR014118 http://www.ebi.ac.uk/interpro/entry/IPR014118 OMA QRIPDAT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QRIPDAT PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:TRAV_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRAV_ECOLI PSORT-B swissprot:TRAV_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRAV_ECOLI PSORT2 swissprot:TRAV_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRAV_ECOLI Pfam PF09676 http://pfam.xfam.org/family/PF09676 Phobius swissprot:TRAV_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRAV_ECOLI ProteinModelPortal P41069 http://www.proteinmodelportal.org/query/uniprot/P41069 PubMed 7915817 http://www.ncbi.nlm.nih.gov/pubmed/7915817 PubMed 8021201 http://www.ncbi.nlm.nih.gov/pubmed/8021201 RefSeq NP_061461 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061461 RefSeq WP_010892541 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_010892541 TIGRFAMs TIGR02747 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02747 UniProtKB TRAV_ECOLI http://www.uniprot.org/uniprot/TRAV_ECOLI UniProtKB-AC P41069 http://www.uniprot.org/uniprot/P41069 charge swissprot:TRAV_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRAV_ECOLI epestfind swissprot:TRAV_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRAV_ECOLI garnier swissprot:TRAV_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRAV_ECOLI helixturnhelix swissprot:TRAV_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRAV_ECOLI hmoment swissprot:TRAV_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRAV_ECOLI iep swissprot:TRAV_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRAV_ECOLI inforesidue swissprot:TRAV_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRAV_ECOLI octanol swissprot:TRAV_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRAV_ECOLI pepcoil swissprot:TRAV_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRAV_ECOLI pepdigest swissprot:TRAV_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRAV_ECOLI pepinfo swissprot:TRAV_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRAV_ECOLI pepnet swissprot:TRAV_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRAV_ECOLI pepstats swissprot:TRAV_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRAV_ECOLI pepwheel swissprot:TRAV_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRAV_ECOLI pepwindow swissprot:TRAV_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRAV_ECOLI sigcleave swissprot:TRAV_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRAV_ECOLI ## Database ID URL or Descriptions # EcoGene EG11016 tpr # Organism PRTL_ECOLI Escherichia coli (strain K12) # PIR A90813 WRECP1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PRTL_ECOLI Protamine-like protein # RefSeq NP_415747 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA24670.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA36099.1; Type=Erroneous initiation; Evidence={ECO 0000305}; BLAST swissprot:PRTL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PRTL_ECOLI BioCyc ECOL316407:JW1219-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1219-MONOMER BioCyc EcoCyc:EG11016-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11016-MONOMER DOI 10.1016/0092-8674(81)90198-7 http://dx.doi.org/10.1016/0092-8674(81)90198-7 DOI 10.1016/0092-8674(81)90199-9 http://dx.doi.org/10.1016/0092-8674(81)90199-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K01197 http://www.ebi.ac.uk/ena/data/view/K01197 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1009 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1009 EcoGene EG11016 http://www.ecogene.org/geneInfo.php?eg_id=EG11016 EnsemblBacteria AAC74313 http://www.ensemblgenomes.org/id/AAC74313 EnsemblBacteria AAC74313 http://www.ensemblgenomes.org/id/AAC74313 EnsemblBacteria BAA36099 http://www.ensemblgenomes.org/id/BAA36099 EnsemblBacteria BAA36099 http://www.ensemblgenomes.org/id/BAA36099 EnsemblBacteria BAA36099 http://www.ensemblgenomes.org/id/BAA36099 EnsemblBacteria b1229 http://www.ensemblgenomes.org/id/b1229 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946224 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946224 HOGENOM HOG000054855 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000054855&db=HOGENOM6 KEGG_Gene ecj:JW1219 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1219 KEGG_Gene eco:b1229 http://www.genome.jp/dbget-bin/www_bget?eco:b1229 PSORT swissprot:PRTL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PRTL_ECOLI PSORT-B swissprot:PRTL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PRTL_ECOLI PSORT2 swissprot:PRTL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PRTL_ECOLI Phobius swissprot:PRTL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PRTL_ECOLI PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7034959 http://www.ncbi.nlm.nih.gov/pubmed/7034959 PubMed 7034960 http://www.ncbi.nlm.nih.gov/pubmed/7034960 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415747 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415747 STRING 511145.b1229 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1229&targetmode=cogs UniProtKB PRTL_ECOLI http://www.uniprot.org/uniprot/PRTL_ECOLI UniProtKB-AC P02338 http://www.uniprot.org/uniprot/P02338 charge swissprot:PRTL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PRTL_ECOLI epestfind swissprot:PRTL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PRTL_ECOLI garnier swissprot:PRTL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PRTL_ECOLI helixturnhelix swissprot:PRTL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PRTL_ECOLI hmoment swissprot:PRTL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PRTL_ECOLI iep swissprot:PRTL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PRTL_ECOLI inforesidue swissprot:PRTL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PRTL_ECOLI octanol swissprot:PRTL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PRTL_ECOLI pepcoil swissprot:PRTL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PRTL_ECOLI pepdigest swissprot:PRTL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PRTL_ECOLI pepinfo swissprot:PRTL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PRTL_ECOLI pepnet swissprot:PRTL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PRTL_ECOLI pepstats swissprot:PRTL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PRTL_ECOLI pepwheel swissprot:PRTL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PRTL_ECOLI pepwindow swissprot:PRTL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PRTL_ECOLI sigcleave swissprot:PRTL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PRTL_ECOLI ## Database ID URL or Descriptions # BioGrid 4263156 3 # EcoGene EG13801 ydeS # GO_component GO:0009289 pilus; IEA:UniProtKB-SubCell. # GO_process GO:0007155 cell adhesion; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0007155 cell adhesion # Gene3D 2.60.40.1090 -; 1. # InterPro IPR000259 Adhesion_dom_fimbrial # InterPro IPR008966 Adhesion_dom # Organism YDES_ECOLI Escherichia coli (strain K12) # PATRIC 32118304 VBIEscCol129921_1572 # PIR C64904 C64904 # Pfam PF00419 Fimbrial # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDES_ECOLI Uncharacterized fimbrial-like protein YdeS # RefSeq NP_416021 NC_000913.3 # RefSeq WP_000876763 NZ_LN832404.1 # SIMILARITY Belongs to the fimbrial protein family. {ECO 0000305}. # SUBCELLULAR LOCATION YDES_ECOLI Fimbrium {ECO 0000305}. # SUPFAM SSF49401 SSF49401 # eggNOG ENOG4108WDE Bacteria # eggNOG ENOG4111P69 LUCA BLAST swissprot:YDES_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDES_ECOLI BioCyc ECOL316407:JW1498-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1498-MONOMER BioCyc EcoCyc:G6794-MONOMER http://biocyc.org/getid?id=EcoCyc:G6794-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3562 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3562 EcoGene EG13801 http://www.ecogene.org/geneInfo.php?eg_id=EG13801 EnsemblBacteria AAC74577 http://www.ensemblgenomes.org/id/AAC74577 EnsemblBacteria AAC74577 http://www.ensemblgenomes.org/id/AAC74577 EnsemblBacteria BAA15177 http://www.ensemblgenomes.org/id/BAA15177 EnsemblBacteria BAA15177 http://www.ensemblgenomes.org/id/BAA15177 EnsemblBacteria BAA15177 http://www.ensemblgenomes.org/id/BAA15177 EnsemblBacteria b1504 http://www.ensemblgenomes.org/id/b1504 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009289 GO_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 Gene3D 2.60.40.1090 http://www.cathdb.info/version/latest/superfamily/2.60.40.1090 GeneID 946047 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946047 HOGENOM HOG000260127 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260127&db=HOGENOM6 InParanoid P77789 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77789 InterPro IPR000259 http://www.ebi.ac.uk/interpro/entry/IPR000259 InterPro IPR008966 http://www.ebi.ac.uk/interpro/entry/IPR008966 KEGG_Gene ecj:JW1498 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1498 KEGG_Gene eco:b1504 http://www.genome.jp/dbget-bin/www_bget?eco:b1504 OMA SARMKST http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SARMKST PSORT swissprot:YDES_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDES_ECOLI PSORT-B swissprot:YDES_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDES_ECOLI PSORT2 swissprot:YDES_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDES_ECOLI Pfam PF00419 http://pfam.xfam.org/family/PF00419 Phobius swissprot:YDES_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDES_ECOLI PhylomeDB P77789 http://phylomedb.org/?seqid=P77789 ProteinModelPortal P77789 http://www.proteinmodelportal.org/query/uniprot/P77789 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416021 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416021 RefSeq WP_000876763 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000876763 SMR P77789 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77789 STRING 511145.b1504 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1504&targetmode=cogs SUPFAM SSF49401 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49401 UniProtKB YDES_ECOLI http://www.uniprot.org/uniprot/YDES_ECOLI UniProtKB-AC P77789 http://www.uniprot.org/uniprot/P77789 charge swissprot:YDES_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDES_ECOLI eggNOG ENOG4108WDE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108WDE eggNOG ENOG4111P69 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111P69 epestfind swissprot:YDES_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDES_ECOLI garnier swissprot:YDES_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDES_ECOLI helixturnhelix swissprot:YDES_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDES_ECOLI hmoment swissprot:YDES_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDES_ECOLI iep swissprot:YDES_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDES_ECOLI inforesidue swissprot:YDES_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDES_ECOLI octanol swissprot:YDES_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDES_ECOLI pepcoil swissprot:YDES_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDES_ECOLI pepdigest swissprot:YDES_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDES_ECOLI pepinfo swissprot:YDES_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDES_ECOLI pepnet swissprot:YDES_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDES_ECOLI pepstats swissprot:YDES_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDES_ECOLI pepwheel swissprot:YDES_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDES_ECOLI pepwindow swissprot:YDES_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDES_ECOLI sigcleave swissprot:YDES_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDES_ECOLI ## Database ID URL or Descriptions # AltName BTUR_ECOLI Cob(I)alamin adenosyltransferase # AltName BTUR_ECOLI Corrinoid adenosyltransferase # BioGrid 4259575 6 # CATALYTIC ACTIVITY BTUR_ECOLI ATP + cob(I)yrinic acid a,c-diamide = triphosphate + adenosylcob(III)yrinic acid a,c-diamide. # CATALYTIC ACTIVITY BTUR_ECOLI ATP + cobinamide = triphosphate + adenosylcobinamide. # CDD cd00561 CobA_CobO_BtuR # EcoGene EG10130 btuR # FUNCTION BTUR_ECOLI Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids (By similarity). {ECO 0000250}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0008817 cob(I)yrinic acid a,c-diamide adenosyltransferase activity; ISS:EcoCyc. # GO_process GO:0006779 porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0009236 cobalamin biosynthetic process; IMP:EcoCyc. # GO_process GO:0019250 aerobic cobalamin biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.300 -; 1. # IntAct P0A9H5 14 # InterPro IPR003724 CblAdoTrfase_CobA # InterPro IPR025826 Co_AT_N_dom # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00860 Porphyrin and chlorophyll metabolism # Organism BTUR_ECOLI Escherichia coli (strain K12) # PATHWAY Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide step 2/7. # PATRIC 32117798 VBIEscCol129921_1319 # PIR A64875 A64875 # PIRSF PIRSF015617 Adensltrnsf_CobA # Pfam PF02572 CobA_CobO_BtuR # Pfam PF12557 Co_AT_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BTUR_ECOLI Cob(I)yrinic acid a,c-diamide adenosyltransferase # RefSeq NP_415786 NC_000913.3 # RefSeq WP_001278906 NZ_LN832404.1 # SIMILARITY Belongs to the Cob(I)alamin adenosyltransferase family. {ECO 0000305}. # SUBCELLULAR LOCATION BTUR_ECOLI Cytoplasm. # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR00708 cobA # UniPathway UPA00148 UER00233 # eggNOG COG2109 LUCA # eggNOG ENOG41068B1 Bacteria BLAST swissprot:BTUR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BTUR_ECOLI BioCyc ECOL316407:JW1262-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1262-MONOMER BioCyc EcoCyc:COBALADENOSYLTRANS-MONOMER http://biocyc.org/getid?id=EcoCyc:COBALADENOSYLTRANS-MONOMER COG COG2109 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2109 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.5.1.17 http://www.genome.jp/dbget-bin/www_bget?EC:2.5.1.17 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M21528 http://www.ebi.ac.uk/ena/data/view/M21528 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.5.1.17 http://enzyme.expasy.org/EC/2.5.1.17 EchoBASE EB0128 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0128 EcoGene EG10130 http://www.ecogene.org/geneInfo.php?eg_id=EG10130 EnsemblBacteria AAC74352 http://www.ensemblgenomes.org/id/AAC74352 EnsemblBacteria AAC74352 http://www.ensemblgenomes.org/id/AAC74352 EnsemblBacteria BAA14807 http://www.ensemblgenomes.org/id/BAA14807 EnsemblBacteria BAA14807 http://www.ensemblgenomes.org/id/BAA14807 EnsemblBacteria BAA14807 http://www.ensemblgenomes.org/id/BAA14807 EnsemblBacteria b1270 http://www.ensemblgenomes.org/id/b1270 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008817 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008817 GO_process GO:0006779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006779 GO_process GO:0009236 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009236 GO_process GO:0019250 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019250 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016765 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945839 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945839 HOGENOM HOG000260311 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260311&db=HOGENOM6 InParanoid P0A9H5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9H5 IntAct P0A9H5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9H5* IntEnz 2.5.1.17 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.5.1.17 InterPro IPR003724 http://www.ebi.ac.uk/interpro/entry/IPR003724 InterPro IPR025826 http://www.ebi.ac.uk/interpro/entry/IPR025826 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1262 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1262 KEGG_Gene eco:b1270 http://www.genome.jp/dbget-bin/www_bget?eco:b1270 KEGG_Orthology KO:K00798 http://www.genome.jp/dbget-bin/www_bget?KO:K00798 KEGG_Pathway ko00860 http://www.genome.jp/kegg-bin/show_pathway?ko00860 KEGG_Reaction rn:R05220 http://www.genome.jp/dbget-bin/www_bget?rn:R05220 KEGG_Reaction rn:R07268 http://www.genome.jp/dbget-bin/www_bget?rn:R07268 OMA HAMGEGF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HAMGEGF PSORT swissprot:BTUR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BTUR_ECOLI PSORT-B swissprot:BTUR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BTUR_ECOLI PSORT2 swissprot:BTUR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BTUR_ECOLI Pfam PF02572 http://pfam.xfam.org/family/PF02572 Pfam PF12557 http://pfam.xfam.org/family/PF12557 Phobius swissprot:BTUR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BTUR_ECOLI PhylomeDB P0A9H5 http://phylomedb.org/?seqid=P0A9H5 ProteinModelPortal P0A9H5 http://www.proteinmodelportal.org/query/uniprot/P0A9H5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2644187 http://www.ncbi.nlm.nih.gov/pubmed/2644187 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415786 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415786 RefSeq WP_001278906 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001278906 SMR P0A9H5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9H5 STRING 511145.b1270 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1270&targetmode=cogs STRING COG2109 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2109&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR00708 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00708 UniProtKB BTUR_ECOLI http://www.uniprot.org/uniprot/BTUR_ECOLI UniProtKB-AC P0A9H5 http://www.uniprot.org/uniprot/P0A9H5 charge swissprot:BTUR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BTUR_ECOLI eggNOG COG2109 http://eggnogapi.embl.de/nog_data/html/tree/COG2109 eggNOG ENOG41068B1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41068B1 epestfind swissprot:BTUR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BTUR_ECOLI garnier swissprot:BTUR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BTUR_ECOLI helixturnhelix swissprot:BTUR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BTUR_ECOLI hmoment swissprot:BTUR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BTUR_ECOLI iep swissprot:BTUR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BTUR_ECOLI inforesidue swissprot:BTUR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BTUR_ECOLI octanol swissprot:BTUR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BTUR_ECOLI pepcoil swissprot:BTUR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BTUR_ECOLI pepdigest swissprot:BTUR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BTUR_ECOLI pepinfo swissprot:BTUR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BTUR_ECOLI pepnet swissprot:BTUR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BTUR_ECOLI pepstats swissprot:BTUR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BTUR_ECOLI pepwheel swissprot:BTUR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BTUR_ECOLI pepwindow swissprot:BTUR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BTUR_ECOLI sigcleave swissprot:BTUR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BTUR_ECOLI ## Database ID URL or Descriptions # BioGrid 4261462 274 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # Organism YJGW_ECOLI Escherichia coli (strain K12) # PIR S56499 S56499 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJGW_ECOLI Putative uncharacterized protein YjgW BLAST swissprot:YJGW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJGW_ECOLI BioCyc ECOL316407:JW4233-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4233-MONOMER BioCyc EcoCyc:G7896-MONOMER http://biocyc.org/getid?id=EcoCyc:G7896-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EnsemblBacteria BAE78270 http://www.ensemblgenomes.org/id/BAE78270 EnsemblBacteria BAE78270 http://www.ensemblgenomes.org/id/BAE78270 EnsemblBacteria BAE78270 http://www.ensemblgenomes.org/id/BAE78270 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv KEGG_Gene ecj:JW4233 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4233 PSORT swissprot:YJGW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJGW_ECOLI PSORT-B swissprot:YJGW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJGW_ECOLI PSORT2 swissprot:YJGW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJGW_ECOLI Phobius swissprot:YJGW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJGW_ECOLI ProteinModelPortal Q9Z3A0 http://www.proteinmodelportal.org/query/uniprot/Q9Z3A0 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 STRING 316407.85677020 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85677020&targetmode=cogs UniProtKB YJGW_ECOLI http://www.uniprot.org/uniprot/YJGW_ECOLI UniProtKB-AC Q9Z3A0 http://www.uniprot.org/uniprot/Q9Z3A0 charge swissprot:YJGW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJGW_ECOLI epestfind swissprot:YJGW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJGW_ECOLI garnier swissprot:YJGW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJGW_ECOLI helixturnhelix swissprot:YJGW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJGW_ECOLI hmoment swissprot:YJGW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJGW_ECOLI iep swissprot:YJGW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJGW_ECOLI inforesidue swissprot:YJGW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJGW_ECOLI octanol swissprot:YJGW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJGW_ECOLI pepcoil swissprot:YJGW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJGW_ECOLI pepdigest swissprot:YJGW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJGW_ECOLI pepinfo swissprot:YJGW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJGW_ECOLI pepnet swissprot:YJGW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJGW_ECOLI pepstats swissprot:YJGW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJGW_ECOLI pepwheel swissprot:YJGW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJGW_ECOLI pepwindow swissprot:YJGW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJGW_ECOLI sigcleave swissprot:YJGW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJGW_ECOLI ## Database ID URL or Descriptions # BRENDA 2.7.13 2026 # BioGrid 4262839 3 # CATALYTIC ACTIVITY TORS_ECOLI ATP + protein L-histidine = ADP + protein N- phospho-L-histidine. # CDD cd06225 HAMP # ENZYME REGULATION TORS_ECOLI Inhibited by TorC apocytochrome. # EcoGene EG12617 torS # FUNCTION TORS_ECOLI Member of the two-component regulatory system TorS/TorR involved in the anaerobic utilization of trimethylamine-N-oxide (TMAO). Detects the presence of TMAO in the medium and, in response, activates TorR via a four-step phosphorelay. When TMAO is removed, TorS can dephosphorylate TorR, probably by a reverse phosphorelay involving His-860 and Asp-733. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0000155 phosphorelay sensor kinase activity; IMP:EcoCyc. # GO_function GO:0004721 phosphoprotein phosphatase activity; IMP:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016772 transferase activity, transferring phosphorus-containing groups; IMP:EcoCyc. # GO_function GO:0016868 intramolecular transferase activity, phosphotransferases; IMP:EcoCyc. # GO_process GO:0000160 phosphorelay signal transduction system; IMP:EcoCyc. # GO_process GO:0009061 anaerobic respiration; IMP:EcoCyc. # GO_process GO:0046777 protein autophosphorylation; IMP:EcoCyc. # GO_process GO:0071310 cellular response to organic substance; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005622 intracellular # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # Gene3D 1.10.287.130 -; 1. # Gene3D 1.20.120.160 -; 1. # Gene3D 3.30.565.10 -; 1. # InterPro IPR001789 Sig_transdc_resp-reg_receiver # InterPro IPR003594 HATPase_C # InterPro IPR003660 HAMP_dom # InterPro IPR003661 HisK_dim/P # InterPro IPR004358 Sig_transdc_His_kin-like_C # InterPro IPR005467 His_kinase_dom # InterPro IPR008207 Sig_transdc_His_kin_Hpt_dom # InterPro IPR011006 CheY-like_superfamily # InterPro IPR014302 Sig_transdc_His_kinase_TorS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01001 Protein kinases # KEGG_Brite ko02022 M00455 TorS-TorR (trimethylamine N-oxide respiration) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # Organism TORS_ECOLI Escherichia coli (strain K12) # PATRIC 32117211 VBIEscCol129921_1029 # PDB 3I9W X-ray; 2.70 A; A=35-320 # PIR G64840 G64840 # PIRSF PIRSF036437 HK_TorS # PRINTS PR00344 BCTRLSENSOR # PROSITE PS50109 HIS_KIN # PROSITE PS50110 RESPONSE_REGULATORY # PROSITE PS50885 HAMP # PROSITE PS50894 HPT # PTM TORS_ECOLI Activation requires a sequential transfer of a phosphate group from a His in the primary transmitter domain, to an Asp in the receiver domain and to a His in the secondary transmitter domain. # Pfam PF00072 Response_reg # Pfam PF00512 HisKA # Pfam PF00672 HAMP # Pfam PF01627 Hpt # Pfam PF02518 HATPase_c # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TORS_ECOLI Sensor protein TorS # RefSeq NP_415513 NC_000913.3 # SEQUENCE CAUTION Sequence=CAA63920.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Contains 1 HAMP domain. {ECO:0000255|PROSITE- ProRule PRU00102}. # SIMILARITY Contains 1 HPt domain. {ECO:0000255|PROSITE- ProRule PRU00110}. # SIMILARITY Contains 1 histidine kinase domain. {ECO:0000255|PROSITE-ProRule PRU00107}. # SIMILARITY Contains 1 response regulatory domain. {ECO:0000255|PROSITE-ProRule PRU00169}. # SMART SM00073 HPT # SMART SM00304 HAMP # SMART SM00387 HATPase_c # SMART SM00388 HisKA # SMART SM00448 REC # SUBCELLULAR LOCATION TORS_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # SUBUNIT TORS_ECOLI May form homomultimers. Seems to interact with TorT and TorC apocytochrome. # SUPFAM SSF47226 SSF47226 # SUPFAM SSF47384 SSF47384 # SUPFAM SSF52172 SSF52172 # SUPFAM SSF55874 SSF55874 # TIGRFAMs TIGR02956 TMAO_torS # eggNOG COG0784 LUCA # eggNOG COG2198 LUCA # eggNOG ENOG4105BZU Bacteria BLAST swissprot:TORS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TORS_ECOLI BioCyc ECOL316407:JW5135-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5135-MONOMER BioCyc EcoCyc:TORS-MONOMER http://biocyc.org/getid?id=EcoCyc:TORS-MONOMER DIP DIP-11017N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11017N DOI 10.1006/jmbi.1997.0919 http://dx.doi.org/10.1006/jmbi.1997.0919 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1996.tb02648.x http://dx.doi.org/10.1111/j.1365-2958.1996.tb02648.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.183.8.2691-2695.2001 http://dx.doi.org/10.1128/JB.183.8.2691-2695.2001 EC_number EC:2.7.13.3 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.13.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X94231 http://www.ebi.ac.uk/ena/data/view/X94231 ENZYME 2.7.13.3 http://enzyme.expasy.org/EC/2.7.13.3 EchoBASE EB2501 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2501 EcoGene EG12617 http://www.ecogene.org/geneInfo.php?eg_id=EG12617 EnsemblBacteria AAC74078 http://www.ensemblgenomes.org/id/AAC74078 EnsemblBacteria AAC74078 http://www.ensemblgenomes.org/id/AAC74078 EnsemblBacteria BAA36135 http://www.ensemblgenomes.org/id/BAA36135 EnsemblBacteria BAA36135 http://www.ensemblgenomes.org/id/BAA36135 EnsemblBacteria BAA36135 http://www.ensemblgenomes.org/id/BAA36135 EnsemblBacteria b0993 http://www.ensemblgenomes.org/id/b0993 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0000155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000155 GO_function GO:0004721 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004721 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016772 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016772 GO_function GO:0016868 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016868 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0009061 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009061 GO_process GO:0046777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046777 GO_process GO:0071310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071310 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.10.287.130 http://www.cathdb.info/version/latest/superfamily/1.10.287.130 Gene3D 1.20.120.160 http://www.cathdb.info/version/latest/superfamily/1.20.120.160 Gene3D 3.30.565.10 http://www.cathdb.info/version/latest/superfamily/3.30.565.10 GeneID 945595 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945595 HOGENOM HOG000118852 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118852&db=HOGENOM6 InParanoid P39453 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39453 IntAct P39453 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39453* IntEnz 2.7.13.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.13.3 InterPro IPR001789 http://www.ebi.ac.uk/interpro/entry/IPR001789 InterPro IPR003594 http://www.ebi.ac.uk/interpro/entry/IPR003594 InterPro IPR003660 http://www.ebi.ac.uk/interpro/entry/IPR003660 InterPro IPR003661 http://www.ebi.ac.uk/interpro/entry/IPR003661 InterPro IPR004358 http://www.ebi.ac.uk/interpro/entry/IPR004358 InterPro IPR005467 http://www.ebi.ac.uk/interpro/entry/IPR005467 InterPro IPR008207 http://www.ebi.ac.uk/interpro/entry/IPR008207 InterPro IPR011006 http://www.ebi.ac.uk/interpro/entry/IPR011006 InterPro IPR014302 http://www.ebi.ac.uk/interpro/entry/IPR014302 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01001 http://www.genome.jp/dbget-bin/www_bget?ko01001 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW5135 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5135 KEGG_Gene eco:b0993 http://www.genome.jp/dbget-bin/www_bget?eco:b0993 KEGG_Orthology KO:K07647 http://www.genome.jp/dbget-bin/www_bget?KO:K07647 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA IAVSAHV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IAVSAHV PDB 3I9W http://www.ebi.ac.uk/pdbe-srv/view/entry/3I9W PDBsum 3I9W http://www.ebi.ac.uk/pdbsum/3I9W PRINTS PR00344 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00344 PROSITE PS50109 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50109 PROSITE PS50110 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50110 PROSITE PS50885 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50885 PROSITE PS50894 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50894 PSORT swissprot:TORS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TORS_ECOLI PSORT-B swissprot:TORS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TORS_ECOLI PSORT2 swissprot:TORS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TORS_ECOLI Pfam PF00072 http://pfam.xfam.org/family/PF00072 Pfam PF00512 http://pfam.xfam.org/family/PF00512 Pfam PF00672 http://pfam.xfam.org/family/PF00672 Pfam PF01627 http://pfam.xfam.org/family/PF01627 Pfam PF02518 http://pfam.xfam.org/family/PF02518 Phobius swissprot:TORS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TORS_ECOLI PhylomeDB P39453 http://phylomedb.org/?seqid=P39453 ProteinModelPortal P39453 http://www.proteinmodelportal.org/query/uniprot/P39453 PubMed 11274133 http://www.ncbi.nlm.nih.gov/pubmed/11274133 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8083154 http://www.ncbi.nlm.nih.gov/pubmed/8083154 PubMed 8809780 http://www.ncbi.nlm.nih.gov/pubmed/8809780 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9135110 http://www.ncbi.nlm.nih.gov/pubmed/9135110 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415513 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415513 SMART SM00073 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00073 SMART SM00304 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00304 SMART SM00387 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00387 SMART SM00388 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00388 SMART SM00448 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00448 SMR P39453 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39453 STRING 511145.b0993 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0993&targetmode=cogs SUPFAM SSF47226 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47226 SUPFAM SSF47384 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47384 SUPFAM SSF52172 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52172 SUPFAM SSF55874 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55874 TIGRFAMs TIGR02956 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02956 UniProtKB TORS_ECOLI http://www.uniprot.org/uniprot/TORS_ECOLI UniProtKB-AC P39453 http://www.uniprot.org/uniprot/P39453 charge swissprot:TORS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TORS_ECOLI eggNOG COG0784 http://eggnogapi.embl.de/nog_data/html/tree/COG0784 eggNOG COG2198 http://eggnogapi.embl.de/nog_data/html/tree/COG2198 eggNOG ENOG4105BZU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZU epestfind swissprot:TORS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TORS_ECOLI garnier swissprot:TORS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TORS_ECOLI helixturnhelix swissprot:TORS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TORS_ECOLI hmoment swissprot:TORS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TORS_ECOLI iep swissprot:TORS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TORS_ECOLI inforesidue swissprot:TORS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TORS_ECOLI octanol swissprot:TORS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TORS_ECOLI pepcoil swissprot:TORS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TORS_ECOLI pepdigest swissprot:TORS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TORS_ECOLI pepinfo swissprot:TORS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TORS_ECOLI pepnet swissprot:TORS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TORS_ECOLI pepstats swissprot:TORS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TORS_ECOLI pepwheel swissprot:TORS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TORS_ECOLI pepwindow swissprot:TORS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TORS_ECOLI sigcleave swissprot:TORS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TORS_ECOLI ## Database ID URL or Descriptions # AltName GLXK2_ECOLI D-Glycerate-3-kinase # AltName GLXK2_ECOLI GK2 # BIOPHYSICOCHEMICAL PROPERTIES GLXK2_ECOLI Kinetic parameters KM=0.07 mM for glycerate {ECO 0000269|PubMed 4887503}; pH dependence Optimum pH is 7.0-7.6. {ECO 0000269|PubMed 4887503}; # BRENDA 2.7.1.165 2165 # BioGrid 4262012 9 # CATALYTIC ACTIVITY GLXK2_ECOLI ATP + D-glycerate = ADP + 3-phospho-D- glycerate. # CAUTION E.coli has 2 glycerate kinases, GK1 and GK2; it is not clear which gene encodes which enzyme. PubMed:5325263 may be a mix of GK1 and GK2. {ECO 0000305}. # COFACTOR GLXK2_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 5325263}; Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000269|PubMed 5325263}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 5325263}; Name=Fe(2+); Xref=ChEBI CHEBI 29033; Evidence={ECO 0000269|PubMed 5325263}; Name=Ca(2+); Xref=ChEBI CHEBI 29108; Evidence={ECO 0000269|PubMed 5325263}; Note=Divalent metal cations; Mg(2+) and Co(2+) are better than Mn(2+), Fe(2+) or Ca(2+). {ECO 0000269|PubMed 5325263}; # DISRUPTION PHENOTYPE Loss of glycerate kinase activity. {ECO:0000269|PubMed 10601204}. # ENZYME REGULATION Inhibited by EDTA, p-hydroxy-mercuribenzoate and iodoacetate but not by NaF. {ECO:0000269|PubMed 5325263}. # EcoGene EG13621 glxK # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0008887 glycerate kinase activity; IEA:UniProtKB-EC. # GO_function GO:0043798 glycerate 2-kinase activity; IDA:EcoCyc. # GO_process GO:0009436 glyoxylate catabolic process; IMP:EcoCyc. # GO_process GO:0031388 organic acid phosphorylation; IEA:InterPro. # GO_process GO:0046296 glycolate catabolic process; IEP:EcoCyc. # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.90.1510.10 -; 1. # INDUCTION GLXK2_ECOLI In glycolate-grown cells but not in glucose-grown cells (at protein level). {ECO 0000269|PubMed 4887503, ECO 0000269|PubMed 5325263}. # IntAct P77364 2 # InterPro IPR004381 Glycerate_kinase # InterPro IPR018193 Glyc_kinase_flavodox-like-dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00260 Glycine, serine and threonine metabolism # KEGG_Pathway ko00561 Glycerolipid metabolism # KEGG_Pathway ko00630 Glyoxylate and dicarboxylate metabolism # MISCELLANEOUS GLXK2_ECOLI GK1 has a half-life of 92 minutes while GK2 has a half-life of 11 minutes at 49 degrees Celsius. # Organism GLXK2_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21599 PTHR21599 # PATHWAY Organic acid metabolism; glycolate degradation; 3- phospho-D-glycerate from glycolate step 4/4. # PATRIC 32116185 VBIEscCol129921_0534 # PIR A64783 A64783 # PIRSF PIRSF006078 GlxK # Pfam PF02595 Gly_kinase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLXK2_ECOLI Glycerate kinase # RefSeq NP_415047 NC_000913.3 # RefSeq WP_001333621 NZ_LN832404.1 # SIMILARITY Belongs to the glycerate kinase type-1 family. {ECO 0000305}. # SUPFAM SSF110738 SSF110738 # TIGRFAMs TIGR00045 TIGR00045 # UniPathway UPA00864 UER00833 # eggNOG COG1929 LUCA # eggNOG ENOG4105BZW Bacteria BLAST swissprot:GLXK2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLXK2_ECOLI BioCyc ECOL316407:JW0502-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0502-MONOMER BioCyc EcoCyc:GLY3KIN-MONOMER http://biocyc.org/getid?id=EcoCyc:GLY3KIN-MONOMER BioCyc MetaCyc:GLY3KIN-MONOMER http://biocyc.org/getid?id=MetaCyc:GLY3KIN-MONOMER COG COG1929 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1929 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.31 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.31 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL U89279 http://www.ebi.ac.uk/ena/data/view/U89279 ENZYME 2.7.1.31 http://enzyme.expasy.org/EC/2.7.1.31 EchoBASE EB3386 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3386 EcoGene EG13621 http://www.ecogene.org/geneInfo.php?eg_id=EG13621 EnsemblBacteria AAC73616 http://www.ensemblgenomes.org/id/AAC73616 EnsemblBacteria AAC73616 http://www.ensemblgenomes.org/id/AAC73616 EnsemblBacteria BAE76292 http://www.ensemblgenomes.org/id/BAE76292 EnsemblBacteria BAE76292 http://www.ensemblgenomes.org/id/BAE76292 EnsemblBacteria BAE76292 http://www.ensemblgenomes.org/id/BAE76292 EnsemblBacteria b0514 http://www.ensemblgenomes.org/id/b0514 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008887 GO_function GO:0043798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043798 GO_process GO:0009436 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009436 GO_process GO:0031388 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031388 GO_process GO:0046296 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046296 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.90.1510.10 http://www.cathdb.info/version/latest/superfamily/3.90.1510.10 GeneID 945129 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945129 HOGENOM HOG000089298 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000089298&db=HOGENOM6 InParanoid P77364 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77364 IntAct P77364 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77364* IntEnz 2.7.1.31 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.31 InterPro IPR004381 http://www.ebi.ac.uk/interpro/entry/IPR004381 InterPro IPR018193 http://www.ebi.ac.uk/interpro/entry/IPR018193 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0502 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0502 KEGG_Gene eco:b0514 http://www.genome.jp/dbget-bin/www_bget?eco:b0514 KEGG_Orthology KO:K00865 http://www.genome.jp/dbget-bin/www_bget?KO:K00865 KEGG_Pathway ko00260 http://www.genome.jp/kegg-bin/show_pathway?ko00260 KEGG_Pathway ko00561 http://www.genome.jp/kegg-bin/show_pathway?ko00561 KEGG_Pathway ko00630 http://www.genome.jp/kegg-bin/show_pathway?ko00630 KEGG_Reaction rn:R01514 http://www.genome.jp/dbget-bin/www_bget?rn:R01514 OMA SIEMNEC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SIEMNEC PANTHER PTHR21599 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21599 PSORT swissprot:GLXK2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLXK2_ECOLI PSORT-B swissprot:GLXK2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLXK2_ECOLI PSORT2 swissprot:GLXK2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLXK2_ECOLI Pfam PF02595 http://pfam.xfam.org/family/PF02595 Phobius swissprot:GLXK2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLXK2_ECOLI PhylomeDB P77364 http://phylomedb.org/?seqid=P77364 ProteinModelPortal P77364 http://www.proteinmodelportal.org/query/uniprot/P77364 PubMed 10601204 http://www.ncbi.nlm.nih.gov/pubmed/10601204 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 4887503 http://www.ncbi.nlm.nih.gov/pubmed/4887503 PubMed 5325263 http://www.ncbi.nlm.nih.gov/pubmed/5325263 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415047 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415047 RefSeq WP_001333621 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001333621 SMR P77364 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77364 STRING 511145.b0514 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0514&targetmode=cogs STRING COG1929 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1929&targetmode=cogs SUPFAM SSF110738 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF110738 TIGRFAMs TIGR00045 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00045 UniProtKB GLXK2_ECOLI http://www.uniprot.org/uniprot/GLXK2_ECOLI UniProtKB-AC P77364 http://www.uniprot.org/uniprot/P77364 charge swissprot:GLXK2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLXK2_ECOLI eggNOG COG1929 http://eggnogapi.embl.de/nog_data/html/tree/COG1929 eggNOG ENOG4105BZW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZW epestfind swissprot:GLXK2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLXK2_ECOLI garnier swissprot:GLXK2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLXK2_ECOLI helixturnhelix swissprot:GLXK2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLXK2_ECOLI hmoment swissprot:GLXK2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLXK2_ECOLI iep swissprot:GLXK2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLXK2_ECOLI inforesidue swissprot:GLXK2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLXK2_ECOLI octanol swissprot:GLXK2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLXK2_ECOLI pepcoil swissprot:GLXK2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLXK2_ECOLI pepdigest swissprot:GLXK2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLXK2_ECOLI pepinfo swissprot:GLXK2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLXK2_ECOLI pepnet swissprot:GLXK2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLXK2_ECOLI pepstats swissprot:GLXK2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLXK2_ECOLI pepwheel swissprot:GLXK2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLXK2_ECOLI pepwindow swissprot:GLXK2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLXK2_ECOLI sigcleave swissprot:GLXK2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLXK2_ECOLI ## Database ID URL or Descriptions # AltName RPOA_ECOLI RNA polymerase subunit alpha # AltName RPOA_ECOLI Transcriptase subunit alpha # BioGrid 4263398 9 # CATALYTIC ACTIVITY RPOA_ECOLI Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). # DOMAIN RPOA_ECOLI The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators (such as CRP) and with upstream promoter elements. {ECO 0000269|PubMed 1646077, ECO 0000269|PubMed 2235479}. # DrugBank DB00615 Rifabutin # EcoGene EG10893 rpoA # FUNCTION RPOA_ECOLI DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit plays an important role in subunit assembly since its dimerization is the first step in the sequential assembly of subunits to form the holoenzyme. {ECO 0000269|PubMed 1646077}. # GO_component GO:0005737 cytoplasm; IDA:UniProtKB. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0003899 DNA-directed RNA polymerase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0008270 zinc ion binding; IDA:EcoliWiki. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 2.170.120.12 -; 1. # HAMAP MF_00059 RNApol_bact_RpoA # INTERACTION RPOA_ECOLI P60422 rplB; NbExp=5; IntAct=EBI-544985, EBI-543515; # IntAct P0A7Z4 85 # InterPro IPR009025 RBP11-like_dimer # InterPro IPR011260 RNAP_asu_C # InterPro IPR011262 DNA-dir_RNA_pol_insert # InterPro IPR011263 DNA-dir_RNA_pol_RpoA/D/Rpb3 # InterPro IPR011773 DNA-dir_RpoA # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03021 M00183 RNA polymerase, bacteria # KEGG_Brite ko03021 Transcription machinery # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Brite ko03400 M00183 RNA polymerase, bacteria # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00240 Pyrimidine metabolism # KEGG_Pathway ko03020 RNA polymerase # Organism RPOA_ECOLI Escherichia coli (strain K12) # PATRIC 32122022 VBIEscCol129921_3388 # PDB 1BDF X-ray; 2.50 A; A/B/C/D=1-235 # PDB 1COO NMR; -; A=233-329 # PDB 1LB2 X-ray; 3.10 A; B/E=246-329 # PDB 1XS9 NMR; -; D=249-329 # PDB 3IYD EM; -; A/B=1-329 # PDB 3K4G X-ray; 2.05 A; A/B/C/D/E/F/G/H=245-329 # PDB 3LU0 EM; -; A/B=1-329 # PDB 3N4M X-ray; 2.99 A; B/C=246-329 # PDB 3N97 X-ray; 3.25 A; B/C=246-329 # PDB 4JK1 X-ray; 3.90 A; A/B/F/G=1-329 # PDB 4JK2 X-ray; 4.20 A; A/B/F/G=1-329 # PDB 4KMU X-ray; 3.85 A; A/B/F/G=1-329 # PDB 4KN4 X-ray; 3.96 A; A/B/F/G=1-329 # PDB 4KN7 X-ray; 3.69 A; A/B/F/G=1-329 # PDB 4MEX X-ray; 3.90 A; A/B/G/H=1-329 # PDB 4MEY X-ray; 3.95 A; A/B/G/H=1-329 # PDB 4S20 X-ray; 4.70 A; A/B/F/G=1-329 # PDB 4XSX X-ray; 3.71 A; A/B/G/H=1-234 # PDB 4XSY X-ray; 4.01 A; A/B/G/H=1-234 # PDB 4XSZ X-ray; 3.68 A; A/B/G/H=1-234 # PDB 4YG2 X-ray; 3.70 A; A/B/G/H=1-329 # PDB 4YLN X-ray; 5.50 A; A/B/G/H/M/N=1-235 # PDB 4YLO X-ray; 6.00 A; A/B/G/H/M/N=1-235 # PDB 4YLP X-ray; 5.50 A; A/B/G/H/M/N=1-235 # PDB 4ZH2 X-ray; 4.20 A; A/B/G/H=2-329 # PDB 4ZH3 X-ray; 4.08 A; A/B/G/H=2-329 # PDB 4ZH4 X-ray; 3.99 A; A/B/G/H=2-329 # PDB 5BYH X-ray; 3.76 A; A/B=1-329 # PDB 5CIZ X-ray; 5.01 A; B=246-329 # PDB 5EZK X-ray; 8.50 A; A/B=1-329 # PDB 5IPL X-ray; 3.60 A; A/B=1-235 # PDB 5IPM X-ray; 4.20 A; A/B=1-235 # PDB 5IPN X-ray; 4.61 A; A/B=1-235 # PIR A22884 RNECA # PTM RPOA_ECOLI Acetylated on Lys-297 and Lys-298 in the presence of glucose. Pka controls acetylation of Lys-298 but not of Lys-297. {ECO 0000269|PubMed 21696463}. # Pfam PF01000 RNA_pol_A_bac # Pfam PF01193 RNA_pol_L # Pfam PF03118 RNA_pol_A_CTD # ProDom PD001179 RNAP_asu_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RPOA_ECOLI DNA-directed RNA polymerase subunit alpha # RefSeq NP_417754 NC_000913.3 # RefSeq WP_001162094 NZ_LN832404.1 # SIMILARITY Belongs to the RNA polymerase alpha chain family. {ECO 0000305}. # SMART SM00662 RPOLD # SUBUNIT RPOA_ECOLI Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. Both the N- and C-terminus interact with different regions of transcriptional regulator CRP. {ECO 0000269|PubMed 12202833, ECO 0000269|PubMed 1646077, ECO 0000269|PubMed 19903881, ECO 0000269|PubMed 2235479}. # SUPFAM SSF55257 SSF55257; 2 # SUPFAM SSF56553 SSF56553 # TIGRFAMs TIGR02027 rpoA # eggNOG COG0202 LUCA BLAST swissprot:RPOA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RPOA_ECOLI BioCyc ECOL316407:JW3257-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3257-MONOMER BioCyc EcoCyc:EG10893-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10893-MONOMER BioCyc MetaCyc:EG10893-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10893-MONOMER COG COG0202 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0202 DIP DIP-35879N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35879N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1007/BF00330268 http://dx.doi.org/10.1007/BF00330268 DOI 10.1016/0014-5793(75)81001-5 http://dx.doi.org/10.1016/0014-5793(75)81001-5 DOI 10.1016/0014-5793(77)80131-2 http://dx.doi.org/10.1016/0014-5793(77)80131-2 DOI 10.1016/0092-8674(91)90553-B http://dx.doi.org/10.1016/0092-8674(91)90553-B DOI 10.1016/S0092-8674(00)81806-1 http://dx.doi.org/10.1016/S0092-8674(00)81806-1 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0908782106 http://dx.doi.org/10.1073/pnas.0908782106 DOI 10.1093/nar/12.14.5813 http://dx.doi.org/10.1093/nar/12.14.5813 DOI 10.1093/nar/13.11.3891 http://dx.doi.org/10.1093/nar/13.11.3891 DOI 10.1093/nar/18.20.5945 http://dx.doi.org/10.1093/nar/18.20.5945 DOI 10.1111/j.1365-2958.2011.07742.x http://dx.doi.org/10.1111/j.1365-2958.2011.07742.x DOI 10.1126/science.1076376 http://dx.doi.org/10.1126/science.1076376 DOI 10.1126/science.270.5241.1495 http://dx.doi.org/10.1126/science.270.5241.1495 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1126/science.281.5374.262 http://dx.doi.org/10.1126/science.281.5374.262 DrugBank DB00615 http://www.drugbank.ca/drugs/DB00615 EC_number EC:2.7.7.6 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.6 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01685 http://www.ebi.ac.uk/ena/data/view/J01685 EMBL M29822 http://www.ebi.ac.uk/ena/data/view/M29822 EMBL M29823 http://www.ebi.ac.uk/ena/data/view/M29823 EMBL M29824 http://www.ebi.ac.uk/ena/data/view/M29824 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL V00353 http://www.ebi.ac.uk/ena/data/view/V00353 EMBL X00766 http://www.ebi.ac.uk/ena/data/view/X00766 EMBL X02543 http://www.ebi.ac.uk/ena/data/view/X02543 EMBL X53843 http://www.ebi.ac.uk/ena/data/view/X53843 EMBL X53844 http://www.ebi.ac.uk/ena/data/view/X53844 ENZYME 2.7.7.6 http://enzyme.expasy.org/EC/2.7.7.6 EchoBASE EB0886 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0886 EcoGene EG10893 http://www.ecogene.org/geneInfo.php?eg_id=EG10893 EnsemblBacteria AAC76320 http://www.ensemblgenomes.org/id/AAC76320 EnsemblBacteria AAC76320 http://www.ensemblgenomes.org/id/AAC76320 EnsemblBacteria BAE77996 http://www.ensemblgenomes.org/id/BAE77996 EnsemblBacteria BAE77996 http://www.ensemblgenomes.org/id/BAE77996 EnsemblBacteria BAE77996 http://www.ensemblgenomes.org/id/BAE77996 EnsemblBacteria b3295 http://www.ensemblgenomes.org/id/b3295 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003899 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003899 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 2.170.120.12 http://www.cathdb.info/version/latest/superfamily/2.170.120.12 GeneID 947794 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947794 HAMAP MF_00059 http://hamap.expasy.org/unirule/MF_00059 HOGENOM HOG000218481 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218481&db=HOGENOM6 InParanoid P0A7Z4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7Z4 IntAct P0A7Z4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7Z4* IntEnz 2.7.7.6 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.6 InterPro IPR009025 http://www.ebi.ac.uk/interpro/entry/IPR009025 InterPro IPR011260 http://www.ebi.ac.uk/interpro/entry/IPR011260 InterPro IPR011262 http://www.ebi.ac.uk/interpro/entry/IPR011262 InterPro IPR011263 http://www.ebi.ac.uk/interpro/entry/IPR011263 InterPro IPR011773 http://www.ebi.ac.uk/interpro/entry/IPR011773 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03021 http://www.genome.jp/dbget-bin/www_bget?ko03021 KEGG_Brite ko03021 http://www.genome.jp/dbget-bin/www_bget?ko03021 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW3257 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3257 KEGG_Gene eco:b3295 http://www.genome.jp/dbget-bin/www_bget?eco:b3295 KEGG_Orthology KO:K03040 http://www.genome.jp/dbget-bin/www_bget?KO:K03040 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Pathway ko03020 http://www.genome.jp/kegg-bin/show_pathway?ko03020 KEGG_Reaction rn:R00435 http://www.genome.jp/dbget-bin/www_bget?rn:R00435 KEGG_Reaction rn:R00441 http://www.genome.jp/dbget-bin/www_bget?rn:R00441 KEGG_Reaction rn:R00442 http://www.genome.jp/dbget-bin/www_bget?rn:R00442 KEGG_Reaction rn:R00443 http://www.genome.jp/dbget-bin/www_bget?rn:R00443 MINT MINT-6478247 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-6478247 OMA LMKFRNF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LMKFRNF PDB 1BDF http://www.ebi.ac.uk/pdbe-srv/view/entry/1BDF PDB 1COO http://www.ebi.ac.uk/pdbe-srv/view/entry/1COO PDB 1LB2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1LB2 PDB 1XS9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1XS9 PDB 3IYD http://www.ebi.ac.uk/pdbe-srv/view/entry/3IYD PDB 3K4G http://www.ebi.ac.uk/pdbe-srv/view/entry/3K4G PDB 3LU0 http://www.ebi.ac.uk/pdbe-srv/view/entry/3LU0 PDB 3N4M http://www.ebi.ac.uk/pdbe-srv/view/entry/3N4M PDB 3N97 http://www.ebi.ac.uk/pdbe-srv/view/entry/3N97 PDB 4JK1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4JK1 PDB 4JK2 http://www.ebi.ac.uk/pdbe-srv/view/entry/4JK2 PDB 4KMU http://www.ebi.ac.uk/pdbe-srv/view/entry/4KMU PDB 4KN4 http://www.ebi.ac.uk/pdbe-srv/view/entry/4KN4 PDB 4KN7 http://www.ebi.ac.uk/pdbe-srv/view/entry/4KN7 PDB 4MEX http://www.ebi.ac.uk/pdbe-srv/view/entry/4MEX PDB 4MEY http://www.ebi.ac.uk/pdbe-srv/view/entry/4MEY PDB 4S20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4S20 PDB 4XSX http://www.ebi.ac.uk/pdbe-srv/view/entry/4XSX PDB 4XSY http://www.ebi.ac.uk/pdbe-srv/view/entry/4XSY PDB 4XSZ http://www.ebi.ac.uk/pdbe-srv/view/entry/4XSZ PDB 4YG2 http://www.ebi.ac.uk/pdbe-srv/view/entry/4YG2 PDB 4YLN http://www.ebi.ac.uk/pdbe-srv/view/entry/4YLN PDB 4YLO http://www.ebi.ac.uk/pdbe-srv/view/entry/4YLO PDB 4YLP http://www.ebi.ac.uk/pdbe-srv/view/entry/4YLP PDB 4ZH2 http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZH2 PDB 4ZH3 http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZH3 PDB 4ZH4 http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZH4 PDB 5BYH http://www.ebi.ac.uk/pdbe-srv/view/entry/5BYH PDB 5CIZ http://www.ebi.ac.uk/pdbe-srv/view/entry/5CIZ PDB 5EZK http://www.ebi.ac.uk/pdbe-srv/view/entry/5EZK PDB 5IPL http://www.ebi.ac.uk/pdbe-srv/view/entry/5IPL PDB 5IPM http://www.ebi.ac.uk/pdbe-srv/view/entry/5IPM PDB 5IPN http://www.ebi.ac.uk/pdbe-srv/view/entry/5IPN PDBsum 1BDF http://www.ebi.ac.uk/pdbsum/1BDF PDBsum 1COO http://www.ebi.ac.uk/pdbsum/1COO PDBsum 1LB2 http://www.ebi.ac.uk/pdbsum/1LB2 PDBsum 1XS9 http://www.ebi.ac.uk/pdbsum/1XS9 PDBsum 3IYD http://www.ebi.ac.uk/pdbsum/3IYD PDBsum 3K4G http://www.ebi.ac.uk/pdbsum/3K4G PDBsum 3LU0 http://www.ebi.ac.uk/pdbsum/3LU0 PDBsum 3N4M http://www.ebi.ac.uk/pdbsum/3N4M PDBsum 3N97 http://www.ebi.ac.uk/pdbsum/3N97 PDBsum 4JK1 http://www.ebi.ac.uk/pdbsum/4JK1 PDBsum 4JK2 http://www.ebi.ac.uk/pdbsum/4JK2 PDBsum 4KMU http://www.ebi.ac.uk/pdbsum/4KMU PDBsum 4KN4 http://www.ebi.ac.uk/pdbsum/4KN4 PDBsum 4KN7 http://www.ebi.ac.uk/pdbsum/4KN7 PDBsum 4MEX http://www.ebi.ac.uk/pdbsum/4MEX PDBsum 4MEY http://www.ebi.ac.uk/pdbsum/4MEY PDBsum 4S20 http://www.ebi.ac.uk/pdbsum/4S20 PDBsum 4XSX http://www.ebi.ac.uk/pdbsum/4XSX PDBsum 4XSY http://www.ebi.ac.uk/pdbsum/4XSY PDBsum 4XSZ http://www.ebi.ac.uk/pdbsum/4XSZ PDBsum 4YG2 http://www.ebi.ac.uk/pdbsum/4YG2 PDBsum 4YLN http://www.ebi.ac.uk/pdbsum/4YLN PDBsum 4YLO http://www.ebi.ac.uk/pdbsum/4YLO PDBsum 4YLP http://www.ebi.ac.uk/pdbsum/4YLP PDBsum 4ZH2 http://www.ebi.ac.uk/pdbsum/4ZH2 PDBsum 4ZH3 http://www.ebi.ac.uk/pdbsum/4ZH3 PDBsum 4ZH4 http://www.ebi.ac.uk/pdbsum/4ZH4 PDBsum 5BYH http://www.ebi.ac.uk/pdbsum/5BYH PDBsum 5CIZ http://www.ebi.ac.uk/pdbsum/5CIZ PDBsum 5EZK http://www.ebi.ac.uk/pdbsum/5EZK PDBsum 5IPL http://www.ebi.ac.uk/pdbsum/5IPL PDBsum 5IPM http://www.ebi.ac.uk/pdbsum/5IPM PDBsum 5IPN http://www.ebi.ac.uk/pdbsum/5IPN PSORT swissprot:RPOA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RPOA_ECOLI PSORT-B swissprot:RPOA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RPOA_ECOLI PSORT2 swissprot:RPOA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RPOA_ECOLI Pfam PF01000 http://pfam.xfam.org/family/PF01000 Pfam PF01193 http://pfam.xfam.org/family/PF01193 Pfam PF03118 http://pfam.xfam.org/family/PF03118 Phobius swissprot:RPOA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RPOA_ECOLI PhylomeDB P0A7Z4 http://phylomedb.org/?seqid=P0A7Z4 ProteinModelPortal P0A7Z4 http://www.proteinmodelportal.org/query/uniprot/P0A7Z4 PubMed 1095419 http://www.ncbi.nlm.nih.gov/pubmed/1095419 PubMed 12202833 http://www.ncbi.nlm.nih.gov/pubmed/12202833 PubMed 1646077 http://www.ncbi.nlm.nih.gov/pubmed/1646077 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19903881 http://www.ncbi.nlm.nih.gov/pubmed/19903881 PubMed 21696463 http://www.ncbi.nlm.nih.gov/pubmed/21696463 PubMed 2235479 http://www.ncbi.nlm.nih.gov/pubmed/2235479 PubMed 2989779 http://www.ncbi.nlm.nih.gov/pubmed/2989779 PubMed 323055 http://www.ncbi.nlm.nih.gov/pubmed/323055 PubMed 387752 http://www.ncbi.nlm.nih.gov/pubmed/387752 PubMed 3894886 http://www.ncbi.nlm.nih.gov/pubmed/3894886 PubMed 6379605 http://www.ncbi.nlm.nih.gov/pubmed/6379605 PubMed 7491496 http://www.ncbi.nlm.nih.gov/pubmed/7491496 PubMed 8978616 http://www.ncbi.nlm.nih.gov/pubmed/8978616 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9657722 http://www.ncbi.nlm.nih.gov/pubmed/9657722 RefSeq NP_417754 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417754 RefSeq WP_001162094 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001162094 SMART SM00662 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00662 SMR P0A7Z4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7Z4 STRING 511145.b3295 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3295&targetmode=cogs STRING COG0202 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0202&targetmode=cogs SUPFAM SSF55257 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55257 SUPFAM SSF56553 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56553 SWISS-2DPAGE P0A7Z4 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A7Z4 TIGRFAMs TIGR02027 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02027 UniProtKB RPOA_ECOLI http://www.uniprot.org/uniprot/RPOA_ECOLI UniProtKB-AC P0A7Z4 http://www.uniprot.org/uniprot/P0A7Z4 charge swissprot:RPOA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RPOA_ECOLI eggNOG COG0202 http://eggnogapi.embl.de/nog_data/html/tree/COG0202 epestfind swissprot:RPOA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RPOA_ECOLI garnier swissprot:RPOA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RPOA_ECOLI helixturnhelix swissprot:RPOA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RPOA_ECOLI hmoment swissprot:RPOA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RPOA_ECOLI iep swissprot:RPOA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RPOA_ECOLI inforesidue swissprot:RPOA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RPOA_ECOLI octanol swissprot:RPOA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RPOA_ECOLI pepcoil swissprot:RPOA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RPOA_ECOLI pepdigest swissprot:RPOA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RPOA_ECOLI pepinfo swissprot:RPOA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RPOA_ECOLI pepnet swissprot:RPOA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RPOA_ECOLI pepstats swissprot:RPOA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RPOA_ECOLI pepwheel swissprot:RPOA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RPOA_ECOLI pepwindow swissprot:RPOA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RPOA_ECOLI sigcleave swissprot:RPOA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RPOA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261301 515 # DISRUPTION PHENOTYPE Affects the lengths of both the long and short axes of the cell, but especially the long axis. Cells become shorter and fatter and form round or oval shapes. {ECO:0000269|PubMed 19008860}. # DOMAIN RODZ_ECOLI The helix-turn-helix (HTH) motif in the cytoplasmic domain of the N-terminus is involved in the formation of spirals to maintain the rigid rod shape. As this protein is anchored in the cytoplasmic membrane, the HTH motif may contribute to protein- protein interactions to form the RodZ helix, which is localized beneath the cytoplasmic membrane. The C-terminal domain may be critical for determination of the rod shape by probably interacting with enzymes required for synthesis of the peptidoglycan layer, including PBPs in the periplasm. # EcoGene EG10015 yfgA # FUNCTION RODZ_ECOLI Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis. {ECO 0000269|PubMed 19008860}. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0009276 Gram-negative-bacterium-type cell wall; IDA:EcoCyc. # GO_function GO:0043565 sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0008360 regulation of cell shape; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005618 cell wall # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # Gene3D 1.10.260.40 -; 1. # HAMAP MF_02017 RodZ # IntAct P27434 11 # InterPro IPR001387 Cro/C1-type_HTH # InterPro IPR010982 Lambda_DNA-bd_dom # InterPro IPR023690 RodZ # InterPro IPR025194 DUF4115 # Organism RODZ_ECOLI Escherichia coli (strain K12) # PATRIC 32120425 VBIEscCol129921_2615 # PIR C65028 C65028 # PROSITE PS50943 HTH_CROC1 # Pfam PF13413 HTH_25 # Pfam PF13464 DUF4115 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RODZ_ECOLI Cytoskeleton protein RodZ # RefSeq NP_417011 NC_000913.3 # RefSeq WP_001090866 NZ_LN832404.1 # SIMILARITY Belongs to the RodZ family. {ECO 0000305}. # SIMILARITY Contains 1 HTH cro/C1-type DNA-binding domain. {ECO 0000305}. # SMART SM00530 HTH_XRE # SUBCELLULAR LOCATION RODZ_ECOLI Cell inner membrane {ECO 0000269|PubMed 19008860}; Single-pass type II membrane protein {ECO 0000269|PubMed 19008860}. Note=Forms helical filaments along the long axis of the cell. # SUPFAM SSF47413 SSF47413 # eggNOG COG1426 LUCA # eggNOG ENOG4105HSZ Bacteria BLAST swissprot:RODZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RODZ_ECOLI BioCyc ECOL316407:JW2500-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2500-MONOMER BioCyc EcoCyc:EG10015-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10015-MONOMER COG COG1426 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1426 DIP DIP-12034N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12034N DOI 10.1016/0378-1097(92)90604-M http://dx.doi.org/10.1016/0378-1097(92)90604-M DOI 10.1038/emboj.2008.234 http://dx.doi.org/10.1038/emboj.2008.234 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1574-6968.1994.tb07115.x http://dx.doi.org/10.1111/j.1574-6968.1994.tb07115.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1271/bbb.58.117 http://dx.doi.org/10.1271/bbb.58.117 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D21149 http://www.ebi.ac.uk/ena/data/view/D21149 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U02965 http://www.ebi.ac.uk/ena/data/view/U02965 EMBL U83188 http://www.ebi.ac.uk/ena/data/view/U83188 EMBL X64451 http://www.ebi.ac.uk/ena/data/view/X64451 EchoBASE EB0015 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0015 EcoGene EG10015 http://www.ecogene.org/geneInfo.php?eg_id=EG10015 EnsemblBacteria AAC75569 http://www.ensemblgenomes.org/id/AAC75569 EnsemblBacteria AAC75569 http://www.ensemblgenomes.org/id/AAC75569 EnsemblBacteria BAA16403 http://www.ensemblgenomes.org/id/BAA16403 EnsemblBacteria BAA16403 http://www.ensemblgenomes.org/id/BAA16403 EnsemblBacteria BAA16403 http://www.ensemblgenomes.org/id/BAA16403 EnsemblBacteria b2516 http://www.ensemblgenomes.org/id/b2516 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0009276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009276 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005618 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.10.260.40 http://www.cathdb.info/version/latest/superfamily/1.10.260.40 GeneID 946992 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946992 HAMAP MF_02017 http://hamap.expasy.org/unirule/MF_02017 HOGENOM HOG000276142 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276142&db=HOGENOM6 InParanoid P27434 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P27434 IntAct P27434 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P27434* InterPro IPR001387 http://www.ebi.ac.uk/interpro/entry/IPR001387 InterPro IPR010982 http://www.ebi.ac.uk/interpro/entry/IPR010982 InterPro IPR023690 http://www.ebi.ac.uk/interpro/entry/IPR023690 InterPro IPR025194 http://www.ebi.ac.uk/interpro/entry/IPR025194 KEGG_Gene ecj:JW2500 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2500 KEGG_Gene eco:b2516 http://www.genome.jp/dbget-bin/www_bget?eco:b2516 KEGG_Orthology KO:K15539 http://www.genome.jp/dbget-bin/www_bget?KO:K15539 MINT MINT-7012109 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-7012109 OMA ADCWTQV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ADCWTQV PROSITE PS50943 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50943 PSORT swissprot:RODZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RODZ_ECOLI PSORT-B swissprot:RODZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RODZ_ECOLI PSORT2 swissprot:RODZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RODZ_ECOLI Pfam PF13413 http://pfam.xfam.org/family/PF13413 Pfam PF13464 http://pfam.xfam.org/family/PF13464 Phobius swissprot:RODZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RODZ_ECOLI ProteinModelPortal P27434 http://www.proteinmodelportal.org/query/uniprot/P27434 PubMed 1521767 http://www.ncbi.nlm.nih.gov/pubmed/1521767 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19008860 http://www.ncbi.nlm.nih.gov/pubmed/19008860 PubMed 7764507 http://www.ncbi.nlm.nih.gov/pubmed/7764507 PubMed 7926684 http://www.ncbi.nlm.nih.gov/pubmed/7926684 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417011 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417011 RefSeq WP_001090866 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001090866 SMART SM00530 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00530 STRING 511145.b2516 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2516&targetmode=cogs STRING COG1426 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1426&targetmode=cogs SUPFAM SSF47413 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47413 UniProtKB RODZ_ECOLI http://www.uniprot.org/uniprot/RODZ_ECOLI UniProtKB-AC P27434 http://www.uniprot.org/uniprot/P27434 charge swissprot:RODZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RODZ_ECOLI eggNOG COG1426 http://eggnogapi.embl.de/nog_data/html/tree/COG1426 eggNOG ENOG4105HSZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105HSZ epestfind swissprot:RODZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RODZ_ECOLI garnier swissprot:RODZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RODZ_ECOLI helixturnhelix swissprot:RODZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RODZ_ECOLI hmoment swissprot:RODZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RODZ_ECOLI iep swissprot:RODZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RODZ_ECOLI inforesidue swissprot:RODZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RODZ_ECOLI octanol swissprot:RODZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RODZ_ECOLI pepcoil swissprot:RODZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RODZ_ECOLI pepdigest swissprot:RODZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RODZ_ECOLI pepinfo swissprot:RODZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RODZ_ECOLI pepnet swissprot:RODZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RODZ_ECOLI pepstats swissprot:RODZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RODZ_ECOLI pepwheel swissprot:RODZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RODZ_ECOLI pepwindow swissprot:RODZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RODZ_ECOLI sigcleave swissprot:RODZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RODZ_ECOLI ## Database ID URL or Descriptions # BioGrid 4260046 17 # EcoGene EG10472 hyaE # FUNCTION HYAE_ECOLI Not known. Could form, along with HyaD, a complex involved in the processing of the hydrogenase 1 structural operon. # GO_function GO:0005048 signal sequence binding; IPI:EcoCyc. # GOslim_function GO:0003674 molecular_function # Gene3D 3.40.30.10 -; 1. # IntAct P19931 10 # InterPro IPR010893 NiFe-hyd_mat_HyaE # InterPro IPR012336 Thioredoxin-like_fold # Organism HYAE_ECOLI Escherichia coli (strain K12) # PATRIC 32117173 VBIEscCol129921_1010 # PDB 2HFD NMR; -; A=1-132 # PIR JV0076 QQECHE # Pfam PF07449 HyaE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HYAE_ECOLI Hydrogenase-1 operon protein HyaE # RefSeq NP_415495 NC_000913.3 # RefSeq WP_000063978 NZ_LN832404.1 # SIMILARITY Belongs to the HupG/HyaE family. {ECO 0000305}. # SUPFAM SSF52833 SSF52833 # eggNOG ENOG4108VXY Bacteria # eggNOG ENOG4111JYZ LUCA BLAST swissprot:HYAE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HYAE_ECOLI BioCyc ECOL316407:JW0958-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0958-MONOMER BioCyc EcoCyc:EG10472-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10472-MONOMER DIP DIP-9961N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9961N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M34825 http://www.ebi.ac.uk/ena/data/view/M34825 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0467 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0467 EcoGene EG10472 http://www.ecogene.org/geneInfo.php?eg_id=EG10472 EnsemblBacteria AAC74061 http://www.ensemblgenomes.org/id/AAC74061 EnsemblBacteria AAC74061 http://www.ensemblgenomes.org/id/AAC74061 EnsemblBacteria BAA35741 http://www.ensemblgenomes.org/id/BAA35741 EnsemblBacteria BAA35741 http://www.ensemblgenomes.org/id/BAA35741 EnsemblBacteria BAA35741 http://www.ensemblgenomes.org/id/BAA35741 EnsemblBacteria b0976 http://www.ensemblgenomes.org/id/b0976 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005048 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005048 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 Gene3D 3.40.30.10 http://www.cathdb.info/version/latest/superfamily/3.40.30.10 GeneID 945573 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945573 HOGENOM HOG000118819 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118819&db=HOGENOM6 InParanoid P19931 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P19931 IntAct P19931 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P19931* InterPro IPR010893 http://www.ebi.ac.uk/interpro/entry/IPR010893 InterPro IPR012336 http://www.ebi.ac.uk/interpro/entry/IPR012336 KEGG_Gene ecj:JW0958 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0958 KEGG_Gene eco:b0976 http://www.genome.jp/dbget-bin/www_bget?eco:b0976 KEGG_Orthology KO:K03619 http://www.genome.jp/dbget-bin/www_bget?KO:K03619 OMA WHIAMAD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WHIAMAD PDB 2HFD http://www.ebi.ac.uk/pdbe-srv/view/entry/2HFD PDBsum 2HFD http://www.ebi.ac.uk/pdbsum/2HFD PSORT swissprot:HYAE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HYAE_ECOLI PSORT-B swissprot:HYAE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HYAE_ECOLI PSORT2 swissprot:HYAE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HYAE_ECOLI Pfam PF07449 http://pfam.xfam.org/family/PF07449 Phobius swissprot:HYAE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HYAE_ECOLI ProteinModelPortal P19931 http://www.proteinmodelportal.org/query/uniprot/P19931 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2180913 http://www.ncbi.nlm.nih.gov/pubmed/2180913 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415495 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415495 RefSeq WP_000063978 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000063978 SMR P19931 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P19931 STRING 511145.b0976 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0976&targetmode=cogs SUPFAM SSF52833 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52833 UniProtKB HYAE_ECOLI http://www.uniprot.org/uniprot/HYAE_ECOLI UniProtKB-AC P19931 http://www.uniprot.org/uniprot/P19931 charge swissprot:HYAE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HYAE_ECOLI eggNOG ENOG4108VXY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108VXY eggNOG ENOG4111JYZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111JYZ epestfind swissprot:HYAE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HYAE_ECOLI garnier swissprot:HYAE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HYAE_ECOLI helixturnhelix swissprot:HYAE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HYAE_ECOLI hmoment swissprot:HYAE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HYAE_ECOLI iep swissprot:HYAE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HYAE_ECOLI inforesidue swissprot:HYAE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HYAE_ECOLI octanol swissprot:HYAE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HYAE_ECOLI pepcoil swissprot:HYAE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HYAE_ECOLI pepdigest swissprot:HYAE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HYAE_ECOLI pepinfo swissprot:HYAE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HYAE_ECOLI pepnet swissprot:HYAE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HYAE_ECOLI pepstats swissprot:HYAE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HYAE_ECOLI pepwheel swissprot:HYAE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HYAE_ECOLI pepwindow swissprot:HYAE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HYAE_ECOLI sigcleave swissprot:HYAE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HYAE_ECOLI ## Database ID URL or Descriptions # BioGrid 4261055 9 # EcoGene EG11141 yedA # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0022857 transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0055085 transmembrane transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0055085 transmembrane transport # InterPro IPR000620 EamA_dom # InterPro IPR004779 CO/AA/NH_transpt # Organism YEDA_ECOLI Escherichia coli (strain K12) # PATRIC 32119247 VBIEscCol129921_2038 # PIR JS0266 JS0266 # Pfam PF00892 EamA; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEDA_ECOLI Uncharacterized inner membrane transporter YedA # RefSeq NP_416468 NC_000913.3 # RefSeq WP_001212226 NZ_LN832404.1 # SIMILARITY Belongs to the EamA transporter family. {ECO 0000305}. # SIMILARITY Contains 2 EamA domains. {ECO 0000305}. # SUBCELLULAR LOCATION YEDA_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.7.3.22 the drug/metabolite transporter (dmt) superfamily # TIGRFAMs TIGR00950 2A78 # eggNOG ENOG4105FDR Bacteria # eggNOG ENOG4111I0A LUCA BLAST swissprot:YEDA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEDA_ECOLI BioCyc ECOL316407:JW1942-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1942-MONOMER BioCyc EcoCyc:EG11141-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11141-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/nar/17.14.5844 http://dx.doi.org/10.1093/nar/17.14.5844 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X13330 http://www.ebi.ac.uk/ena/data/view/X13330 EchoBASE EB1131 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1131 EcoGene EG11141 http://www.ecogene.org/geneInfo.php?eg_id=EG11141 EnsemblBacteria AAC75025 http://www.ensemblgenomes.org/id/AAC75025 EnsemblBacteria AAC75025 http://www.ensemblgenomes.org/id/AAC75025 EnsemblBacteria BAA15786 http://www.ensemblgenomes.org/id/BAA15786 EnsemblBacteria BAA15786 http://www.ensemblgenomes.org/id/BAA15786 EnsemblBacteria BAA15786 http://www.ensemblgenomes.org/id/BAA15786 EnsemblBacteria b1959 http://www.ensemblgenomes.org/id/b1959 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 946461 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946461 HOGENOM HOG000258419 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000258419&db=HOGENOM6 InParanoid P0AA70 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AA70 InterPro IPR000620 http://www.ebi.ac.uk/interpro/entry/IPR000620 InterPro IPR004779 http://www.ebi.ac.uk/interpro/entry/IPR004779 KEGG_Gene ecj:JW1942 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1942 KEGG_Gene eco:b1959 http://www.genome.jp/dbget-bin/www_bget?eco:b1959 OMA IVYVVWG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IVYVVWG PSORT swissprot:YEDA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEDA_ECOLI PSORT-B swissprot:YEDA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEDA_ECOLI PSORT2 swissprot:YEDA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEDA_ECOLI Pfam PF00892 http://pfam.xfam.org/family/PF00892 Phobius swissprot:YEDA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEDA_ECOLI PhylomeDB P0AA70 http://phylomedb.org/?seqid=P0AA70 ProteinModelPortal P0AA70 http://www.proteinmodelportal.org/query/uniprot/P0AA70 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2527357 http://www.ncbi.nlm.nih.gov/pubmed/2527357 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416468 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416468 RefSeq WP_001212226 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001212226 STRING 511145.b1959 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1959&targetmode=cogs TCDB 2.A.7.3.22 http://www.tcdb.org/search/result.php?tc=2.A.7.3.22 TIGRFAMs TIGR00950 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00950 UniProtKB YEDA_ECOLI http://www.uniprot.org/uniprot/YEDA_ECOLI UniProtKB-AC P0AA70 http://www.uniprot.org/uniprot/P0AA70 charge swissprot:YEDA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEDA_ECOLI eggNOG ENOG4105FDR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FDR eggNOG ENOG4111I0A http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111I0A epestfind swissprot:YEDA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEDA_ECOLI garnier swissprot:YEDA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEDA_ECOLI helixturnhelix swissprot:YEDA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEDA_ECOLI hmoment swissprot:YEDA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEDA_ECOLI iep swissprot:YEDA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEDA_ECOLI inforesidue swissprot:YEDA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEDA_ECOLI octanol swissprot:YEDA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEDA_ECOLI pepcoil swissprot:YEDA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEDA_ECOLI pepdigest swissprot:YEDA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEDA_ECOLI pepinfo swissprot:YEDA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEDA_ECOLI pepnet swissprot:YEDA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEDA_ECOLI pepstats swissprot:YEDA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEDA_ECOLI pepwheel swissprot:YEDA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEDA_ECOLI pepwindow swissprot:YEDA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEDA_ECOLI sigcleave swissprot:YEDA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEDA_ECOLI ## Database ID URL or Descriptions # BioGrid 4263039 7 # DISRUPTION PHENOTYPE Mutants are unable to use DNA as a sole carbon and energy source and show decreased competitive fitness when cocultured with wild-type cells. {ECO:0000269|PubMed 16707682}. # EcoGene EG12924 hofN # FUNCTION HOFN_ECOLI Required for the use of extracellular DNA as a nutrient. {ECO 0000269|PubMed 16707682}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0015976 carbon utilization; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0008150 biological_process # InterPro IPR007813 PilN # KEGG_Brite ko02044 Secretion system # Organism HOFN_ECOLI Escherichia coli (strain K12) # PATRIC 32122220 VBIEscCol129921_3487 # PIR E65134 E65134 # Pfam PF05137 PilN # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HOFN_ECOLI Putative DNA utilization protein HofN # RefSeq NP_417853 NC_000913.3 # RefSeq WP_001069315 NZ_LN832404.1 # SUBCELLULAR LOCATION HOFN_ECOLI Cell membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. # eggNOG COG3166 LUCA # eggNOG ENOG41065NF Bacteria BLAST swissprot:HOFN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HOFN_ECOLI BioCyc ECOL316407:JW3357-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3357-MONOMER BioCyc EcoCyc:G7738-MONOMER http://biocyc.org/getid?id=EcoCyc:G7738-MONOMER COG COG3166 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3166 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01974-05 http://dx.doi.org/10.1128/JB.01974-05 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2760 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2760 EcoGene EG12924 http://www.ecogene.org/geneInfo.php?eg_id=EG12924 EnsemblBacteria AAC76419 http://www.ensemblgenomes.org/id/AAC76419 EnsemblBacteria AAC76419 http://www.ensemblgenomes.org/id/AAC76419 EnsemblBacteria BAE77897 http://www.ensemblgenomes.org/id/BAE77897 EnsemblBacteria BAE77897 http://www.ensemblgenomes.org/id/BAE77897 EnsemblBacteria BAE77897 http://www.ensemblgenomes.org/id/BAE77897 EnsemblBacteria b3394 http://www.ensemblgenomes.org/id/b3394 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0015976 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015976 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 947898 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947898 HOGENOM HOG000125532 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125532&db=HOGENOM6 InterPro IPR007813 http://www.ebi.ac.uk/interpro/entry/IPR007813 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW3357 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3357 KEGG_Gene eco:b3394 http://www.genome.jp/dbget-bin/www_bget?eco:b3394 KEGG_Orthology KO:K12289 http://www.genome.jp/dbget-bin/www_bget?KO:K12289 OMA FFHLNQR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FFHLNQR PSORT swissprot:HOFN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HOFN_ECOLI PSORT-B swissprot:HOFN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HOFN_ECOLI PSORT2 swissprot:HOFN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HOFN_ECOLI Pfam PF05137 http://pfam.xfam.org/family/PF05137 Phobius swissprot:HOFN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HOFN_ECOLI ProteinModelPortal P64634 http://www.proteinmodelportal.org/query/uniprot/P64634 PubMed 16707682 http://www.ncbi.nlm.nih.gov/pubmed/16707682 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417853 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417853 RefSeq WP_001069315 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001069315 STRING 511145.b3394 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3394&targetmode=cogs STRING COG3166 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3166&targetmode=cogs UniProtKB HOFN_ECOLI http://www.uniprot.org/uniprot/HOFN_ECOLI UniProtKB-AC P64634 http://www.uniprot.org/uniprot/P64634 charge swissprot:HOFN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HOFN_ECOLI eggNOG COG3166 http://eggnogapi.embl.de/nog_data/html/tree/COG3166 eggNOG ENOG41065NF http://eggnogapi.embl.de/nog_data/html/tree/ENOG41065NF epestfind swissprot:HOFN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HOFN_ECOLI garnier swissprot:HOFN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HOFN_ECOLI helixturnhelix swissprot:HOFN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HOFN_ECOLI hmoment swissprot:HOFN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HOFN_ECOLI iep swissprot:HOFN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HOFN_ECOLI inforesidue swissprot:HOFN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HOFN_ECOLI octanol swissprot:HOFN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HOFN_ECOLI pepcoil swissprot:HOFN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HOFN_ECOLI pepdigest swissprot:HOFN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HOFN_ECOLI pepinfo swissprot:HOFN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HOFN_ECOLI pepnet swissprot:HOFN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HOFN_ECOLI pepstats swissprot:HOFN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HOFN_ECOLI pepwheel swissprot:HOFN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HOFN_ECOLI pepwindow swissprot:HOFN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HOFN_ECOLI sigcleave swissprot:HOFN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HOFN_ECOLI ## Database ID URL or Descriptions # AltName DEGQ_ECOLI Protease Do # BIOPHYSICOCHEMICAL PROPERTIES pH dependence: Optimum pH is 5.5. The degradation is efficient at pH values between 4.5 and 6. {ECO 0000269|PubMed:21685389}; # BioGrid 4261912 10 # CATALYTIC ACTIVITY DEGQ_ECOLI Acts on substrates that are at least partially unfolded. The cleavage site P1 residue is normally between a pair of hydrophobic residues, such as Val-|-Val. # ENZYME REGULATION Inhibited by diisopropylfluorophosphate (DFP). {ECO:0000269|PubMed 8576051}. # EcoGene EG12612 degQ # FUNCTION DEGQ_ECOLI DegQ could degrade transiently denatured and unfolded proteins which accumulate in the periplasm following stress conditions. DegQ is efficient with Val-Xaa and Ile-Xaa peptide bonds, suggesting a preference for a beta-branched side chain amino acids. Only unfolded proteins devoid of disulfide bonds appear capable to be cleaved, thereby preventing non-specific proteolysis of folded proteins. DegQ can substitute for the periplasmic protease DegP. {ECO 0000269|PubMed 8576051, ECO 0000269|PubMed 8830688}. # GO_component GO:0042597 periplasmic space; IDA:UniProtKB. # GO_component GO:0071575 integral component of external side of plasma membrane; ISA:EcoliWiki. # GO_function GO:0004252 serine-type endopeptidase activity; IDA:UniProtKB. # GO_function GO:0008233 peptidase activity; IDA:EcoliWiki. # GO_function GO:0042802 identical protein binding; IPI:EcoCyc. # GO_process GO:0006508 proteolysis; ISA:EcoliWiki. # GO_process GO:0051603 proteolysis involved in cellular protein catabolic process; IDA:UniProtKB. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008233 peptidase activity # GOslim_process GO:0008150 biological_process # Gene3D 2.30.42.10 -; 2. # IntAct P39099 8 # InterPro IPR001478 PDZ # InterPro IPR001940 Peptidase_S1C # InterPro IPR009003 Peptidase_S1_PA # InterPro IPR011782 Pept_S1C_Do # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # Organism DEGQ_ECOLI Escherichia coli (strain K12) # PATRIC 32121894 VBIEscCol129921_3331 # PDB 3STI X-ray; 2.60 A; A/B/C=28-264 # PDB 3STJ X-ray; 2.60 A; A/B/C/D/E/F/G/H/I/J/K/L=28-364 # PDB 4A8A EM; 14.20 A; A/B/C/D/E/F/G/H/I/J/K/L=28-455 # PDB 4A8B EM; 13.00 A; A/B/C/D/E/F/G/H/I/J/K/L=28-455 # PDB 4A8C EM; 7.50 A; A/B/C/D/E/F/G/H/I/J/K/L=28-455 # PDB 4A9G EM; 7.50 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/Y=28-455 # PIR JC6051 JC6051 # PRINTS PR00834 PROTEASES2C # PROSITE PS50106 PDZ; 2 # Pfam PF00595 PDZ # Pfam PF13180 PDZ_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DEGQ_ECOLI Periplasmic pH-dependent serine endoprotease DegQ # RefSeq NP_417701 NC_000913.3 # RefSeq WP_001295271 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase S1C family. {ECO 0000305}. # SIMILARITY Contains 2 PDZ (DHR) domains. {ECO:0000255|PROSITE- ProRule PRU00143}. # SMART SM00228 PDZ; 2 # SUBCELLULAR LOCATION DEGQ_ECOLI Periplasm {ECO 0000269|PubMed 8576051}. # SUBUNIT DEGQ_ECOLI DegQ can reversibly switch between different oligomeric forms that represent inactive (6-mer) and active (12-and 24-mer) protease states. Substrate binding triggers the conversion of the resting DegQ trimer and hexamer into catalytically active 12- and 24-mers. The conversion of 6-mer (DegQ6) into 12-mer (DegQ12) or 24-mer (DegQ24) is crucial in regulating protease activity. {ECO 0000269|PubMed 21685389, ECO 0000269|PubMed 8830688}. # SUPFAM SSF50156 SSF50156; 2 # SUPFAM SSF50494 SSF50494 # TIGRFAMs TIGR02037 degP_htrA_DO # eggNOG COG0265 LUCA # eggNOG ENOG4105C0H Bacteria BLAST swissprot:DEGQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DEGQ_ECOLI BioCyc ECOL316407:JW3203-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3203-MONOMER BioCyc EcoCyc:G7682-MONOMER http://biocyc.org/getid?id=EcoCyc:G7682-MONOMER BioCyc MetaCyc:G7682-MONOMER http://biocyc.org/getid?id=MetaCyc:G7682-MONOMER COG COG0265 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0265 DIP DIP-9424N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9424N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M111.243832 http://dx.doi.org/10.1074/jbc.M111.243832 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.21.107 http://www.genome.jp/dbget-bin/www_bget?EC:3.4.21.107 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U15661 http://www.ebi.ac.uk/ena/data/view/U15661 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL U32495 http://www.ebi.ac.uk/ena/data/view/U32495 ENZYME 3.4.21.107 http://enzyme.expasy.org/EC/3.4.21.107 EchoBASE EB2496 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2496 EcoGene EG12612 http://www.ecogene.org/geneInfo.php?eg_id=EG12612 EnsemblBacteria AAC76266 http://www.ensemblgenomes.org/id/AAC76266 EnsemblBacteria AAC76266 http://www.ensemblgenomes.org/id/AAC76266 EnsemblBacteria BAE77277 http://www.ensemblgenomes.org/id/BAE77277 EnsemblBacteria BAE77277 http://www.ensemblgenomes.org/id/BAE77277 EnsemblBacteria BAE77277 http://www.ensemblgenomes.org/id/BAE77277 EnsemblBacteria b3234 http://www.ensemblgenomes.org/id/b3234 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_component GO:0071575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071575 GO_function GO:0004252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004252 GO_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0006508 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006508 GO_process GO:0051603 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051603 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 2.30.42.10 http://www.cathdb.info/version/latest/superfamily/2.30.42.10 GeneID 947812 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947812 HOGENOM HOG000223642 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000223642&db=HOGENOM6 InParanoid P39099 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39099 IntAct P39099 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39099* IntEnz 3.4.21.107 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.21.107 InterPro IPR001478 http://www.ebi.ac.uk/interpro/entry/IPR001478 InterPro IPR001940 http://www.ebi.ac.uk/interpro/entry/IPR001940 InterPro IPR009003 http://www.ebi.ac.uk/interpro/entry/IPR009003 InterPro IPR011782 http://www.ebi.ac.uk/interpro/entry/IPR011782 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW3203 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3203 KEGG_Gene eco:b3234 http://www.genome.jp/dbget-bin/www_bget?eco:b3234 KEGG_Orthology KO:K04772 http://www.genome.jp/dbget-bin/www_bget?KO:K04772 MINT MINT-1246722 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1246722 OMA AFRYFFG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AFRYFFG PDB 3STI http://www.ebi.ac.uk/pdbe-srv/view/entry/3STI PDB 3STJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3STJ PDB 4A8A http://www.ebi.ac.uk/pdbe-srv/view/entry/4A8A PDB 4A8B http://www.ebi.ac.uk/pdbe-srv/view/entry/4A8B PDB 4A8C http://www.ebi.ac.uk/pdbe-srv/view/entry/4A8C PDB 4A9G http://www.ebi.ac.uk/pdbe-srv/view/entry/4A9G PDBsum 3STI http://www.ebi.ac.uk/pdbsum/3STI PDBsum 3STJ http://www.ebi.ac.uk/pdbsum/3STJ PDBsum 4A8A http://www.ebi.ac.uk/pdbsum/4A8A PDBsum 4A8B http://www.ebi.ac.uk/pdbsum/4A8B PDBsum 4A8C http://www.ebi.ac.uk/pdbsum/4A8C PDBsum 4A9G http://www.ebi.ac.uk/pdbsum/4A9G PRINTS PR00834 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00834 PROSITE PS50106 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50106 PSORT swissprot:DEGQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DEGQ_ECOLI PSORT-B swissprot:DEGQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DEGQ_ECOLI PSORT2 swissprot:DEGQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DEGQ_ECOLI Pfam PF00595 http://pfam.xfam.org/family/PF00595 Pfam PF13180 http://pfam.xfam.org/family/PF13180 Phobius swissprot:DEGQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DEGQ_ECOLI PhylomeDB P39099 http://phylomedb.org/?seqid=P39099 ProteinModelPortal P39099 http://www.proteinmodelportal.org/query/uniprot/P39099 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21685389 http://www.ncbi.nlm.nih.gov/pubmed/21685389 PubMed 8576051 http://www.ncbi.nlm.nih.gov/pubmed/8576051 PubMed 8830688 http://www.ncbi.nlm.nih.gov/pubmed/8830688 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417701 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417701 RefSeq WP_001295271 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295271 SMART SM00228 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00228 SMR P39099 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39099 STRING 511145.b3234 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3234&targetmode=cogs STRING COG0265 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0265&targetmode=cogs SUPFAM SSF50156 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50156 SUPFAM SSF50494 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50494 SWISS-2DPAGE P39099 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P39099 TIGRFAMs TIGR02037 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02037 UniProtKB DEGQ_ECOLI http://www.uniprot.org/uniprot/DEGQ_ECOLI UniProtKB-AC P39099 http://www.uniprot.org/uniprot/P39099 charge swissprot:DEGQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DEGQ_ECOLI eggNOG COG0265 http://eggnogapi.embl.de/nog_data/html/tree/COG0265 eggNOG ENOG4105C0H http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C0H epestfind swissprot:DEGQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DEGQ_ECOLI garnier swissprot:DEGQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DEGQ_ECOLI helixturnhelix swissprot:DEGQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DEGQ_ECOLI hmoment swissprot:DEGQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DEGQ_ECOLI iep swissprot:DEGQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DEGQ_ECOLI inforesidue swissprot:DEGQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DEGQ_ECOLI octanol swissprot:DEGQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DEGQ_ECOLI pepcoil swissprot:DEGQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DEGQ_ECOLI pepdigest swissprot:DEGQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DEGQ_ECOLI pepinfo swissprot:DEGQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DEGQ_ECOLI pepnet swissprot:DEGQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DEGQ_ECOLI pepstats swissprot:DEGQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DEGQ_ECOLI pepwheel swissprot:DEGQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DEGQ_ECOLI pepwindow swissprot:DEGQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DEGQ_ECOLI sigcleave swissprot:DEGQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DEGQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4263492 22 # EcoGene EG12933 feoC # FUNCTION FEOC_ECOLI May function as a transcriptional regulator that controls feoABC expression. {ECO 0000255|HAMAP-Rule MF_01586, ECO 0000269|PubMed 16718600}. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0005506 iron ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0051536 iron-sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # HAMAP MF_01586 FeoC # INDUCTION FEOC_ECOLI Up-regulated by S-nitrosoglutathione under anaerobic conditions. Repressed by the global regulator Fur. {ECO 0000269|PubMed 15647275, ECO 0000269|PubMed 16718600}. # IntAct P64638 3 # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR015102 Tscrpt_reg_HTH_FeoC # InterPro IPR023732 FeoC # KEGG_Brite ko02000 Transporters # Organism FEOC_ECOLI Escherichia coli (strain K12) # PATRIC 32122256 VBIEscCol129921_3505 # PDB 1XN7 NMR; -; A=1-78 # PIR E65136 E65136 # Pfam PF09012 FeoC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FEOC_ECOLI Probable [Fe-S]-dependent transcriptional repressor {ECO 0000255|HAMAP-Rule MF_01586, ECO 0000303|PubMed 16718600} # RefSeq NP_417869 NC_000913.3 # RefSeq WP_000157586 NZ_LN832404.1 # SIMILARITY Belongs to the FeoC family. {ECO:0000255|HAMAP- Rule MF_01586, ECO:0000305}. # SUPFAM SSF46785 SSF46785 # eggNOG ENOG4105RJD Bacteria # eggNOG ENOG411247E LUCA BLAST swissprot:FEOC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FEOC_ECOLI BioCyc ECOL316407:JW3373-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3373-MONOMER BioCyc EcoCyc:EG12933-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12933-MONOMER DOI 10.1007/s10534-006-0003-2 http://dx.doi.org/10.1007/s10534-006-0003-2 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M410393200 http://dx.doi.org/10.1074/jbc.M410393200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2769 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2769 EcoGene EG12933 http://www.ecogene.org/geneInfo.php?eg_id=EG12933 EnsemblBacteria AAC76435 http://www.ensemblgenomes.org/id/AAC76435 EnsemblBacteria AAC76435 http://www.ensemblgenomes.org/id/AAC76435 EnsemblBacteria BAE77881 http://www.ensemblgenomes.org/id/BAE77881 EnsemblBacteria BAE77881 http://www.ensemblgenomes.org/id/BAE77881 EnsemblBacteria BAE77881 http://www.ensemblgenomes.org/id/BAE77881 EnsemblBacteria b3410 http://www.ensemblgenomes.org/id/b3410 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0051536 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051536 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 947918 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947918 HAMAP MF_01586 http://hamap.expasy.org/unirule/MF_01586 HOGENOM HOG000247605 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000247605&db=HOGENOM6 IntAct P64638 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P64638* InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR015102 http://www.ebi.ac.uk/interpro/entry/IPR015102 InterPro IPR023732 http://www.ebi.ac.uk/interpro/entry/IPR023732 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3373 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3373 KEGG_Gene eco:b3410 http://www.genome.jp/dbget-bin/www_bget?eco:b3410 KEGG_Orthology KO:K07490 http://www.genome.jp/dbget-bin/www_bget?KO:K07490 OMA HTPQPMI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HTPQPMI PDB 1XN7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1XN7 PDBsum 1XN7 http://www.ebi.ac.uk/pdbsum/1XN7 PSORT swissprot:FEOC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FEOC_ECOLI PSORT-B swissprot:FEOC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FEOC_ECOLI PSORT2 swissprot:FEOC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FEOC_ECOLI Pfam PF09012 http://pfam.xfam.org/family/PF09012 Phobius swissprot:FEOC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FEOC_ECOLI ProteinModelPortal P64638 http://www.proteinmodelportal.org/query/uniprot/P64638 PubMed 15647275 http://www.ncbi.nlm.nih.gov/pubmed/15647275 PubMed 16718600 http://www.ncbi.nlm.nih.gov/pubmed/16718600 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417869 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417869 RefSeq WP_000157586 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000157586 SMR P64638 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P64638 STRING 511145.b3410 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3410&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB FEOC_ECOLI http://www.uniprot.org/uniprot/FEOC_ECOLI UniProtKB-AC P64638 http://www.uniprot.org/uniprot/P64638 charge swissprot:FEOC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FEOC_ECOLI eggNOG ENOG4105RJD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105RJD eggNOG ENOG411247E http://eggnogapi.embl.de/nog_data/html/tree/ENOG411247E epestfind swissprot:FEOC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FEOC_ECOLI garnier swissprot:FEOC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FEOC_ECOLI helixturnhelix swissprot:FEOC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FEOC_ECOLI hmoment swissprot:FEOC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FEOC_ECOLI iep swissprot:FEOC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FEOC_ECOLI inforesidue swissprot:FEOC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FEOC_ECOLI octanol swissprot:FEOC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FEOC_ECOLI pepcoil swissprot:FEOC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FEOC_ECOLI pepdigest swissprot:FEOC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FEOC_ECOLI pepinfo swissprot:FEOC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FEOC_ECOLI pepnet swissprot:FEOC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FEOC_ECOLI pepstats swissprot:FEOC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FEOC_ECOLI pepwheel swissprot:FEOC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FEOC_ECOLI pepwindow swissprot:FEOC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FEOC_ECOLI sigcleave swissprot:FEOC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FEOC_ECOLI ## Database ID URL or Descriptions # BioGrid 4259314 8 # EcoGene EG12520 ytfT # FUNCTION YTFT_ECOLI Probably part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IBA:GO_Central. # GO_function GO:0050782 galactose uniporter activity; IDA:EcoCyc. # GO_process GO:0015757 galactose transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR001851 ABC_transp_permease # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00221 Putative simple sugar transport system # KEGG_Brite ko02000 Transporters # Organism YTFT_ECOLI Escherichia coli (strain K12) # PATRIC 32124033 VBIEscCol129921_4361 # PIR S56456 S56456 # Pfam PF02653 BPD_transp_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YTFT_ECOLI Inner membrane ABC transporter permease protein YtfT # RefSeq NP_418651 NC_000913.3 # SEQUENCE CAUTION Sequence=BAE78230.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION YTFT_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 3.A.1.2.25 the atp-binding cassette (abc) superfamily # eggNOG ENOG4107R9N Bacteria # eggNOG ENOG410XPE9 LUCA BLAST swissprot:YTFT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YTFT_ECOLI BioCyc ECOL316407:JW5753-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5753-MONOMER BioCyc EcoCyc:YTFT-MONOMER http://biocyc.org/getid?id=EcoCyc:YTFT-MONOMER BioCyc MetaCyc:YTFT-MONOMER http://biocyc.org/getid?id=MetaCyc:YTFT-MONOMER COG COG1079 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1079 COG COG1172 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1172 DIP DIP-12946N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12946N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2411 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2411 EcoGene EG12520 http://www.ecogene.org/geneInfo.php?eg_id=EG12520 EnsemblBacteria AAC77187 http://www.ensemblgenomes.org/id/AAC77187 EnsemblBacteria AAC77187 http://www.ensemblgenomes.org/id/AAC77187 EnsemblBacteria BAE78230 http://www.ensemblgenomes.org/id/BAE78230 EnsemblBacteria BAE78230 http://www.ensemblgenomes.org/id/BAE78230 EnsemblBacteria BAE78230 http://www.ensemblgenomes.org/id/BAE78230 EnsemblBacteria b4230 http://www.ensemblgenomes.org/id/b4230 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0050782 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050782 GO_process GO:0015757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015757 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948743 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948743 HOGENOM HOG000212234 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000212234&db=HOGENOM6 InParanoid P39328 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39328 IntAct P39328 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39328* InterPro IPR001851 http://www.ebi.ac.uk/interpro/entry/IPR001851 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5753 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5753 KEGG_Gene eco:b4230 http://www.genome.jp/dbget-bin/www_bget?eco:b4230 KEGG_Orthology KO:K02057 http://www.genome.jp/dbget-bin/www_bget?KO:K02057 MINT MINT-1249310 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1249310 OMA FFQIVVQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FFQIVVQ PSORT swissprot:YTFT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YTFT_ECOLI PSORT-B swissprot:YTFT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YTFT_ECOLI PSORT2 swissprot:YTFT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YTFT_ECOLI Pfam PF02653 http://pfam.xfam.org/family/PF02653 Phobius swissprot:YTFT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YTFT_ECOLI PhylomeDB P39328 http://phylomedb.org/?seqid=P39328 ProteinModelPortal P39328 http://www.proteinmodelportal.org/query/uniprot/P39328 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418651 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418651 STRING 511145.b4230 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4230&targetmode=cogs STRING COG1079 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1079&targetmode=cogs STRING COG1172 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1172&targetmode=cogs TCDB 3.A.1.2.25 http://www.tcdb.org/search/result.php?tc=3.A.1.2.25 UniProtKB YTFT_ECOLI http://www.uniprot.org/uniprot/YTFT_ECOLI UniProtKB-AC P39328 http://www.uniprot.org/uniprot/P39328 charge swissprot:YTFT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YTFT_ECOLI eggNOG ENOG4107R9N http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107R9N eggNOG ENOG410XPE9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPE9 epestfind swissprot:YTFT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YTFT_ECOLI garnier swissprot:YTFT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YTFT_ECOLI helixturnhelix swissprot:YTFT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YTFT_ECOLI hmoment swissprot:YTFT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YTFT_ECOLI iep swissprot:YTFT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YTFT_ECOLI inforesidue swissprot:YTFT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YTFT_ECOLI octanol swissprot:YTFT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YTFT_ECOLI pepcoil swissprot:YTFT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YTFT_ECOLI pepdigest swissprot:YTFT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YTFT_ECOLI pepinfo swissprot:YTFT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YTFT_ECOLI pepnet swissprot:YTFT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YTFT_ECOLI pepstats swissprot:YTFT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YTFT_ECOLI pepwheel swissprot:YTFT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YTFT_ECOLI pepwindow swissprot:YTFT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YTFT_ECOLI sigcleave swissprot:YTFT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YTFT_ECOLI ## Database ID URL or Descriptions # AltName OPGB_ECOLI Phosphatidylglycerol--membrane-oligosaccharide glycerophosphotransferase # BioGrid 4261390 163 # CATALYTIC ACTIVITY OPGB_ECOLI Phosphatidylglycerol + membrane-derived- oligosaccharide D-glucose = 1,2-diacyl-sn-glycerol + membrane- derived-oligosaccharide 6-(glycerophospho)-D-glucose. # EcoGene EG12591 mdoB # FUNCTION OPGB_ECOLI Transfers a phosphoglycerol residue from phosphatidylglycerol to the membrane-bound nascent glucan backbones. {ECO 0000269|PubMed 2985566, ECO 0000269|PubMed 6094515}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_component GO:0042597 periplasmic space; IDA:EcoCyc. # GO_function GO:0008484 sulfuric ester hydrolase activity; IEA:InterPro. # GO_function GO:0008960 phosphatidylglycerol-membrane-oligosaccharide glycerophosphotransferase activity; IDA:EcoCyc. # GO_process GO:0006490 oligosaccharide-lipid intermediate biosynthetic process; IDA:EcoCyc. # GO_process GO:0009250 glucan biosynthetic process; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.720.10 -; 1. # HAMAP MF_01070 MdoB_OpgB # InterPro IPR000917 Sulfatase_N # InterPro IPR017849 Alkaline_Pase-like_a/b/a # InterPro IPR017850 Alkaline_phosphatase_core # InterPro IPR020881 Phosphoglycerol_transferase_I # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00561 Glycerolipid metabolism # Organism OPGB_ECOLI Escherichia coli (strain K12) # PATHWAY OPGB_ECOLI Glycan metabolism; osmoregulated periplasmic glucan (OPG) biosynthesis. # PATRIC 32124326 VBIEscCol129921_4506 # PIR S56586 S56586 # Pfam PF00884 Sulfatase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName OPGB_ECOLI Phosphoglycerol transferase I # RefSeq NP_418779 NC_000913.3 # RefSeq WP_001292679 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97258.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the OpgB family. {ECO 0000305}. # SUBCELLULAR LOCATION OPGB_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # SUPFAM SSF53649 SSF53649 # eggNOG COG1368 LUCA # eggNOG ENOG4107RES Bacteria BLAST swissprot:OPGB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:OPGB_ECOLI BioCyc ECOL316407:JW5794-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5794-MONOMER BioCyc EcoCyc:PGLYCEROLTRANSI-MONOMER http://biocyc.org/getid?id=EcoCyc:PGLYCEROLTRANSI-MONOMER BioCyc MetaCyc:PGLYCEROLTRANSI-MONOMER http://biocyc.org/getid?id=MetaCyc:PGLYCEROLTRANSI-MONOMER COG COG1368 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1368 DIP DIP-10175N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10175N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.8.20 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.8.20 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 2.7.8.20 http://enzyme.expasy.org/EC/2.7.8.20 EchoBASE EB2476 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2476 EcoGene EG12591 http://www.ecogene.org/geneInfo.php?eg_id=EG12591 EnsemblBacteria AAC77315 http://www.ensemblgenomes.org/id/AAC77315 EnsemblBacteria AAC77315 http://www.ensemblgenomes.org/id/AAC77315 EnsemblBacteria BAE78349 http://www.ensemblgenomes.org/id/BAE78349 EnsemblBacteria BAE78349 http://www.ensemblgenomes.org/id/BAE78349 EnsemblBacteria BAE78349 http://www.ensemblgenomes.org/id/BAE78349 EnsemblBacteria b4359 http://www.ensemblgenomes.org/id/b4359 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0008484 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008484 GO_function GO:0008960 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008960 GO_process GO:0006490 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006490 GO_process GO:0009250 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009250 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.720.10 http://www.cathdb.info/version/latest/superfamily/3.40.720.10 GeneID 948888 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948888 HAMAP MF_01070 http://hamap.expasy.org/unirule/MF_01070 HOGENOM HOG000127573 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000127573&db=HOGENOM6 IntAct P39401 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39401* IntEnz 2.7.8.20 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.8.20 InterPro IPR000917 http://www.ebi.ac.uk/interpro/entry/IPR000917 InterPro IPR017849 http://www.ebi.ac.uk/interpro/entry/IPR017849 InterPro IPR017850 http://www.ebi.ac.uk/interpro/entry/IPR017850 InterPro IPR020881 http://www.ebi.ac.uk/interpro/entry/IPR020881 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5794 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5794 KEGG_Gene eco:b4359 http://www.genome.jp/dbget-bin/www_bget?eco:b4359 KEGG_Orthology KO:K01002 http://www.genome.jp/dbget-bin/www_bget?KO:K01002 KEGG_Pathway ko00561 http://www.genome.jp/kegg-bin/show_pathway?ko00561 KEGG_Reaction rn:R05081 http://www.genome.jp/dbget-bin/www_bget?rn:R05081 MINT MINT-1305397 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1305397 OMA SPWFKNT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SPWFKNT PSORT swissprot:OPGB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:OPGB_ECOLI PSORT-B swissprot:OPGB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:OPGB_ECOLI PSORT2 swissprot:OPGB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:OPGB_ECOLI Pfam PF00884 http://pfam.xfam.org/family/PF00884 Phobius swissprot:OPGB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:OPGB_ECOLI ProteinModelPortal P39401 http://www.proteinmodelportal.org/query/uniprot/P39401 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2985566 http://www.ncbi.nlm.nih.gov/pubmed/2985566 PubMed 6094515 http://www.ncbi.nlm.nih.gov/pubmed/6094515 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418779 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418779 RefSeq WP_001292679 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001292679 SMR P39401 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39401 STRING 511145.b4359 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4359&targetmode=cogs STRING COG1368 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1368&targetmode=cogs SUPFAM SSF53649 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53649 UniProtKB OPGB_ECOLI http://www.uniprot.org/uniprot/OPGB_ECOLI UniProtKB-AC P39401 http://www.uniprot.org/uniprot/P39401 charge swissprot:OPGB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:OPGB_ECOLI eggNOG COG1368 http://eggnogapi.embl.de/nog_data/html/tree/COG1368 eggNOG ENOG4107RES http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107RES epestfind swissprot:OPGB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:OPGB_ECOLI garnier swissprot:OPGB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:OPGB_ECOLI helixturnhelix swissprot:OPGB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:OPGB_ECOLI hmoment swissprot:OPGB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:OPGB_ECOLI iep swissprot:OPGB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:OPGB_ECOLI inforesidue swissprot:OPGB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:OPGB_ECOLI octanol swissprot:OPGB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:OPGB_ECOLI pepcoil swissprot:OPGB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:OPGB_ECOLI pepdigest swissprot:OPGB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:OPGB_ECOLI pepinfo swissprot:OPGB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:OPGB_ECOLI pepnet swissprot:OPGB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:OPGB_ECOLI pepstats swissprot:OPGB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:OPGB_ECOLI pepwheel swissprot:OPGB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:OPGB_ECOLI pepwindow swissprot:OPGB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:OPGB_ECOLI sigcleave swissprot:OPGB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:OPGB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260955 10 # EcoGene EG14071 rcnA # FUNCTION RCNA_ECOLI Efflux system for nickel and cobalt. {ECO 0000269|PubMed 15805538}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; ISM:EcoCyc. # GO_component GO:0043231 intracellular membrane-bounded organelle; IBA:GO_Central. # GO_function GO:0015099 nickel cation transmembrane transporter activity; IMP:EcoCyc. # GO_function GO:0043682 copper-transporting ATPase activity; IBA:GO_Central. # GO_function GO:0046583 cation efflux transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:InterPro. # GO_process GO:0006824 cobalt ion transport; IEA:UniProtKB-KW. # GO_process GO:0010045 response to nickel cation; IEP:EcoCyc. # GO_process GO:0032025 response to cobalt ion; IEP:EcoCyc. # GO_process GO:0035444 nickel cation transmembrane transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043226 organelle # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # GOslim_process GO:0055085 transmembrane transport # INDUCTION By nickel and cobalt. Transcriptionally repressed by RcnR. Probably also regulated by Fur. Cadmium, copper and zinc have no effect on the transcription. {ECO:0000269|PubMed 15805538}. # InterPro IPR011541 Ni/Co_transpt_high_affinity # KEGG_Brite ko02000 Transporters # Organism RCNA_ECOLI Escherichia coli (strain K12) # PATRIC 32119545 VBIEscCol129921_2183 # PIR A64978 A64978 # Pfam PF03824 NicO # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RCNA_ECOLI Nickel/cobalt efflux system RcnA # RefSeq NP_416609 NC_000913.3 # RefSeq WP_000134636 NZ_LN832404.1 # SIMILARITY Belongs to the NiCoT transporter (TC 2.A.52) family. RcnA subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION RCNA_ECOLI Cell inner membrane {ECO 0000269|PubMed 15805538}; Multi-pass membrane protein {ECO 0000269|PubMed 15805538}. # TCDB 2.A.113.1 2.a.113. the nickel/cobalt transporter (nico) family # eggNOG COG2215 LUCA # eggNOG ENOG41061MD Bacteria BLAST swissprot:RCNA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RCNA_ECOLI BioCyc ECOL316407:JW2093-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2093-MONOMER BioCyc EcoCyc:G7138-MONOMER http://biocyc.org/getid?id=EcoCyc:G7138-MONOMER COG COG2215 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2215 DOI 10.1007/s10534-006-9039-6 http://dx.doi.org/10.1007/s10534-006-9039-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1111/j.1365-2958.2006.05369.x http://dx.doi.org/10.1111/j.1365-2958.2006.05369.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.187.8.2912-2916.2005 http://dx.doi.org/10.1128/JB.187.8.2912-2916.2005 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3824 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3824 EcoGene EG14071 http://www.ecogene.org/geneInfo.php?eg_id=EG14071 EnsemblBacteria AAC75167 http://www.ensemblgenomes.org/id/AAC75167 EnsemblBacteria AAC75167 http://www.ensemblgenomes.org/id/AAC75167 EnsemblBacteria BAA15973 http://www.ensemblgenomes.org/id/BAA15973 EnsemblBacteria BAA15973 http://www.ensemblgenomes.org/id/BAA15973 EnsemblBacteria BAA15973 http://www.ensemblgenomes.org/id/BAA15973 EnsemblBacteria b2106 http://www.ensemblgenomes.org/id/b2106 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0043231 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231 GO_function GO:0015099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015099 GO_function GO:0043682 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043682 GO_function GO:0046583 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046583 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006824 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006824 GO_process GO:0010045 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010045 GO_process GO:0032025 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032025 GO_process GO:0035444 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035444 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 949078 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949078 HOGENOM HOG000230055 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230055&db=HOGENOM6 InParanoid P76425 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76425 InterPro IPR011541 http://www.ebi.ac.uk/interpro/entry/IPR011541 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2093 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2093 KEGG_Gene eco:b2106 http://www.genome.jp/dbget-bin/www_bget?eco:b2106 KEGG_Orthology KO:K08970 http://www.genome.jp/dbget-bin/www_bget?KO:K08970 OMA MLWRTWR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MLWRTWR PSORT swissprot:RCNA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RCNA_ECOLI PSORT-B swissprot:RCNA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RCNA_ECOLI PSORT2 swissprot:RCNA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RCNA_ECOLI Pfam PF03824 http://pfam.xfam.org/family/PF03824 Phobius swissprot:RCNA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RCNA_ECOLI PhylomeDB P76425 http://phylomedb.org/?seqid=P76425 ProteinModelPortal P76425 http://www.proteinmodelportal.org/query/uniprot/P76425 PubMed 15805538 http://www.ncbi.nlm.nih.gov/pubmed/15805538 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16956381 http://www.ncbi.nlm.nih.gov/pubmed/16956381 PubMed 17120142 http://www.ncbi.nlm.nih.gov/pubmed/17120142 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416609 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416609 RefSeq WP_000134636 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000134636 STRING 511145.b2106 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2106&targetmode=cogs STRING COG2215 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2215&targetmode=cogs TCDB 2.A.113.1 http://www.tcdb.org/search/result.php?tc=2.A.113.1 UniProtKB RCNA_ECOLI http://www.uniprot.org/uniprot/RCNA_ECOLI UniProtKB-AC P76425 http://www.uniprot.org/uniprot/P76425 charge swissprot:RCNA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RCNA_ECOLI eggNOG COG2215 http://eggnogapi.embl.de/nog_data/html/tree/COG2215 eggNOG ENOG41061MD http://eggnogapi.embl.de/nog_data/html/tree/ENOG41061MD epestfind swissprot:RCNA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RCNA_ECOLI garnier swissprot:RCNA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RCNA_ECOLI helixturnhelix swissprot:RCNA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RCNA_ECOLI hmoment swissprot:RCNA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RCNA_ECOLI iep swissprot:RCNA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RCNA_ECOLI inforesidue swissprot:RCNA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RCNA_ECOLI octanol swissprot:RCNA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RCNA_ECOLI pepcoil swissprot:RCNA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RCNA_ECOLI pepdigest swissprot:RCNA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RCNA_ECOLI pepinfo swissprot:RCNA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RCNA_ECOLI pepnet swissprot:RCNA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RCNA_ECOLI pepstats swissprot:RCNA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RCNA_ECOLI pepwheel swissprot:RCNA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RCNA_ECOLI pepwindow swissprot:RCNA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RCNA_ECOLI sigcleave swissprot:RCNA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RCNA_ECOLI ## Database ID URL or Descriptions # BioGrid 4263519 7 # EcoGene EG11946 nrfC # FUNCTION NRFC_ECOLI Probably involved in the transfer of electrons from the quinone pool to the type-c cytochromes. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0042279 nitrite reductase (cytochrome, ammonia-forming) activity; IMP:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # IntAct P0AAK7 3 # InterPro IPR006311 TAT_signal # InterPro IPR017567 Cyt_c_NO2Rdtase_NrfC # InterPro IPR017896 4Fe4S_Fe-S-bd # InterPro IPR017900 4Fe4S_Fe_S_CS # InterPro IPR019546 TAT_signal_bac_arc # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko00910 Nitrogen metabolism # Organism NRFC_ECOLI Escherichia coli (strain K12) # PATRIC 32123693 VBIEscCol129921_4195 # PIR C57987 C57987 # PROSITE PS00198 4FE4S_FER_1 # PROSITE PS51318 TAT # PROSITE PS51379 4FE4S_FER_2; 3 # PTM NRFC_ECOLI Exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven. # Pfam PF00037 Fer4 # Pfam PF13247 Fer4_11 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NRFC_ECOLI Protein NrfC # RefSeq NP_418496 NC_000913.3 # RefSeq WP_000220281 NZ_LN832404.1 # SIMILARITY Contains 3 4Fe-4S ferredoxin-type domains. {ECO:0000255|PROSITE-ProRule PRU00711}. # TIGRFAMs TIGR01409 TAT_signal_seq # TIGRFAMs TIGR03149 cyt_nit_nrfC # eggNOG COG0437 LUCA # eggNOG ENOG4105D3S Bacteria BLAST swissprot:NRFC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NRFC_ECOLI BioCyc ECOL316407:JW4033-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4033-MONOMER BioCyc EcoCyc:NRFC-MONOMER http://biocyc.org/getid?id=EcoCyc:NRFC-MONOMER BioCyc MetaCyc:NRFC-MONOMER http://biocyc.org/getid?id=MetaCyc:NRFC-MONOMER COG COG0437 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0437 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M610507200 http://dx.doi.org/10.1074/jbc.M610507200 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1111/j.1365-2958.1994.tb01004.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb01004.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X72298 http://www.ebi.ac.uk/ena/data/view/X72298 EchoBASE EB1889 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1889 EcoGene EG11946 http://www.ecogene.org/geneInfo.php?eg_id=EG11946 EnsemblBacteria AAC77042 http://www.ensemblgenomes.org/id/AAC77042 EnsemblBacteria AAC77042 http://www.ensemblgenomes.org/id/AAC77042 EnsemblBacteria BAE78074 http://www.ensemblgenomes.org/id/BAE78074 EnsemblBacteria BAE78074 http://www.ensemblgenomes.org/id/BAE78074 EnsemblBacteria BAE78074 http://www.ensemblgenomes.org/id/BAE78074 EnsemblBacteria b4072 http://www.ensemblgenomes.org/id/b4072 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0042279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042279 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GeneID 948581 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948581 HOGENOM HOG000163388 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000163388&db=HOGENOM6 InParanoid P0AAK7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAK7 IntAct P0AAK7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAK7* InterPro IPR006311 http://www.ebi.ac.uk/interpro/entry/IPR006311 InterPro IPR017567 http://www.ebi.ac.uk/interpro/entry/IPR017567 InterPro IPR017896 http://www.ebi.ac.uk/interpro/entry/IPR017896 InterPro IPR017900 http://www.ebi.ac.uk/interpro/entry/IPR017900 InterPro IPR019546 http://www.ebi.ac.uk/interpro/entry/IPR019546 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW4033 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4033 KEGG_Gene eco:b4072 http://www.genome.jp/dbget-bin/www_bget?eco:b4072 KEGG_Orthology KO:K04014 http://www.genome.jp/dbget-bin/www_bget?KO:K04014 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 OMA KRYAMVH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KRYAMVH PROSITE PS00198 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00198 PROSITE PS51318 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51318 PROSITE PS51379 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51379 PSORT swissprot:NRFC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NRFC_ECOLI PSORT-B swissprot:NRFC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NRFC_ECOLI PSORT2 swissprot:NRFC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NRFC_ECOLI Pfam PF00037 http://pfam.xfam.org/family/PF00037 Pfam PF13247 http://pfam.xfam.org/family/PF13247 Phobius swissprot:NRFC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NRFC_ECOLI PhylomeDB P0AAK7 http://phylomedb.org/?seqid=P0AAK7 ProteinModelPortal P0AAK7 http://www.proteinmodelportal.org/query/uniprot/P0AAK7 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17218314 http://www.ncbi.nlm.nih.gov/pubmed/17218314 PubMed 8057835 http://www.ncbi.nlm.nih.gov/pubmed/8057835 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418496 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418496 RefSeq WP_000220281 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000220281 SMR P0AAK7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAK7 STRING 511145.b4072 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4072&targetmode=cogs STRING COG0437 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0437&targetmode=cogs TIGRFAMs TIGR01409 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01409 TIGRFAMs TIGR03149 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03149 UniProtKB NRFC_ECOLI http://www.uniprot.org/uniprot/NRFC_ECOLI UniProtKB-AC P0AAK7 http://www.uniprot.org/uniprot/P0AAK7 charge swissprot:NRFC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NRFC_ECOLI eggNOG COG0437 http://eggnogapi.embl.de/nog_data/html/tree/COG0437 eggNOG ENOG4105D3S http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D3S epestfind swissprot:NRFC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NRFC_ECOLI garnier swissprot:NRFC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NRFC_ECOLI helixturnhelix swissprot:NRFC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NRFC_ECOLI hmoment swissprot:NRFC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NRFC_ECOLI iep swissprot:NRFC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NRFC_ECOLI inforesidue swissprot:NRFC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NRFC_ECOLI octanol swissprot:NRFC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NRFC_ECOLI pepcoil swissprot:NRFC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NRFC_ECOLI pepdigest swissprot:NRFC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NRFC_ECOLI pepinfo swissprot:NRFC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NRFC_ECOLI pepnet swissprot:NRFC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NRFC_ECOLI pepstats swissprot:NRFC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NRFC_ECOLI pepwheel swissprot:NRFC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NRFC_ECOLI pepwindow swissprot:NRFC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NRFC_ECOLI sigcleave swissprot:NRFC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NRFC_ECOLI ## Database ID URL or Descriptions # BioGrid 4260439 9 # EcoGene EG11997 yehK # IntAct P33347 4 # Organism YEHK_ECOLI Escherichia coli (strain K12) # PATRIC 32119571 VBIEscCol129921_2196 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEHK_ECOLI Uncharacterized protein YehK # RefSeq WP_000636925 NZ_LN832404.1 # RefSeq YP_588459 NC_000913.3 BLAST swissprot:YEHK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEHK_ECOLI BioCyc ECOL316407:JW2106-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2106-MONOMER BioCyc EcoCyc:MONOMER0-2680 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2680 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1937 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1937 EcoGene EG11997 http://www.ecogene.org/geneInfo.php?eg_id=EG11997 EnsemblBacteria ABD18687 http://www.ensemblgenomes.org/id/ABD18687 EnsemblBacteria ABD18687 http://www.ensemblgenomes.org/id/ABD18687 EnsemblBacteria BAE76594 http://www.ensemblgenomes.org/id/BAE76594 EnsemblBacteria BAE76594 http://www.ensemblgenomes.org/id/BAE76594 EnsemblBacteria BAE76594 http://www.ensemblgenomes.org/id/BAE76594 EnsemblBacteria b4541 http://www.ensemblgenomes.org/id/b4541 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 4056035 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4056035 HOGENOM HOG000009750 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009750&db=HOGENOM6 IntAct P33347 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33347* KEGG_Gene ecj:JW2106 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2106 KEGG_Gene eco:b4541 http://www.genome.jp/dbget-bin/www_bget?eco:b4541 OMA DECNDER http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DECNDER PSORT swissprot:YEHK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEHK_ECOLI PSORT-B swissprot:YEHK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEHK_ECOLI PSORT2 swissprot:YEHK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEHK_ECOLI Phobius swissprot:YEHK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEHK_ECOLI ProteinModelPortal P33347 http://www.proteinmodelportal.org/query/uniprot/P33347 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000636925 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000636925 RefSeq YP_588459 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_588459 SMR P33347 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33347 STRING 511145.b4541 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4541&targetmode=cogs UniProtKB YEHK_ECOLI http://www.uniprot.org/uniprot/YEHK_ECOLI UniProtKB-AC P33347 http://www.uniprot.org/uniprot/P33347 charge swissprot:YEHK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEHK_ECOLI epestfind swissprot:YEHK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEHK_ECOLI garnier swissprot:YEHK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEHK_ECOLI helixturnhelix swissprot:YEHK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEHK_ECOLI hmoment swissprot:YEHK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEHK_ECOLI iep swissprot:YEHK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEHK_ECOLI inforesidue swissprot:YEHK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEHK_ECOLI octanol swissprot:YEHK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEHK_ECOLI pepcoil swissprot:YEHK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEHK_ECOLI pepdigest swissprot:YEHK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEHK_ECOLI pepinfo swissprot:YEHK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEHK_ECOLI pepnet swissprot:YEHK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEHK_ECOLI pepstats swissprot:YEHK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEHK_ECOLI pepwheel swissprot:YEHK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEHK_ECOLI pepwindow swissprot:YEHK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEHK_ECOLI sigcleave swissprot:YEHK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEHK_ECOLI ## Database ID URL or Descriptions # Organism TRBG_ECOLI Escherichia coli (strain K12) # RecName TRBG_ECOLI Protein TrbG # RefSeq NP_061460 NC_002483.1 # RefSeq NP_862926 NC_004998.1 # RefSeq WP_001038342 NZ_CP014273.1 # RefSeq YP_001816528 NC_010558.1 # RefSeq YP_001965441 NC_010862.1 # RefSeq YP_003937624 NC_014615.1 # RefSeq YP_009068344 NC_025139.1 # RefSeq YP_009070609 NC_025175.1 # RefSeq YP_009071237 NC_025179.1 BLAST swissprot:TRBG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRBG_ECOLI EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL U01159 http://www.ebi.ac.uk/ena/data/view/U01159 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1263580 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263580 GeneID 1446490 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1446490 GeneID 20491474 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20491474 GeneID 20492677 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20492677 GeneID 20493309 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20493309 GeneID 6275952 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6275952 GeneID 6382237 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6382237 GeneID 9846170 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9846170 OMA KNDFVNC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KNDFVNC PSORT swissprot:TRBG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRBG_ECOLI PSORT-B swissprot:TRBG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRBG_ECOLI PSORT2 swissprot:TRBG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRBG_ECOLI Phobius swissprot:TRBG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRBG_ECOLI ProteinModelPortal P41072 http://www.proteinmodelportal.org/query/uniprot/P41072 PubMed 7915817 http://www.ncbi.nlm.nih.gov/pubmed/7915817 PubMed 8021201 http://www.ncbi.nlm.nih.gov/pubmed/8021201 RefSeq NP_061460 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061460 RefSeq NP_862926 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_862926 RefSeq WP_001038342 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001038342 RefSeq YP_001816528 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001816528 RefSeq YP_001965441 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001965441 RefSeq YP_003937624 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_003937624 RefSeq YP_009068344 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009068344 RefSeq YP_009070609 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009070609 RefSeq YP_009071237 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009071237 SMR P41072 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P41072 UniProtKB TRBG_ECOLI http://www.uniprot.org/uniprot/TRBG_ECOLI UniProtKB-AC P41072 http://www.uniprot.org/uniprot/P41072 charge swissprot:TRBG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRBG_ECOLI epestfind swissprot:TRBG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRBG_ECOLI garnier swissprot:TRBG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRBG_ECOLI helixturnhelix swissprot:TRBG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRBG_ECOLI hmoment swissprot:TRBG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRBG_ECOLI iep swissprot:TRBG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRBG_ECOLI inforesidue swissprot:TRBG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRBG_ECOLI octanol swissprot:TRBG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRBG_ECOLI pepcoil swissprot:TRBG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRBG_ECOLI pepdigest swissprot:TRBG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRBG_ECOLI pepinfo swissprot:TRBG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRBG_ECOLI pepnet swissprot:TRBG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRBG_ECOLI pepstats swissprot:TRBG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRBG_ECOLI pepwheel swissprot:TRBG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRBG_ECOLI pepwindow swissprot:TRBG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRBG_ECOLI sigcleave swissprot:TRBG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRBG_ECOLI ## Database ID URL or Descriptions # BioGrid 4259993 9 # EcoGene EG13683 ybjN # GO_process GO:0009297 pilus assembly; IMP:CACAO. # GO_process GO:0010212 response to ionizing radiation; IMP:EcoCyc. # GO_process GO:0030308 negative regulation of cell growth; IMP:CACAO. # GO_process GO:1900232 negative regulation of single-species biofilm formation on inanimate substrate; IMP:CACAO. # GO_process GO:1902201 negative regulation of bacterial-type flagellum-dependent cell motility; IMP:EcoCyc. # GO_process GO:1902208 regulation of bacterial-type flagellum assembly; IMP:CACAO. # GO_process GO:1902209 negative regulation of bacterial-type flagellum assembly; IMP:CACAO. # GOslim_process GO:0008150 biological_process # GOslim_process GO:0022607 cellular component assembly # INTERACTION YBJN_ECOLI Q46953 ypjF; NbExp=3; IntAct=EBI-9138440, EBI-9134503; # IntAct P0AAY6 7 # InterPro IPR019660 Put_sensory_transdc_reg_YbjN # Organism YBJN_ECOLI Escherichia coli (strain K12) # PATRIC 32116911 VBIEscCol129921_0881 # PIR E64823 E64823 # Pfam PF10722 YbjN # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBJN_ECOLI Uncharacterized protein YbjN # RefSeq NP_415374 NC_000913.3 # RefSeq WP_000203025 NZ_LN832404.1 # eggNOG ENOG4108RMJ Bacteria # eggNOG ENOG4111FKB LUCA BLAST swissprot:YBJN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBJN_ECOLI BioCyc ECOL316407:JW0837-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0837-MONOMER BioCyc EcoCyc:G6447-MONOMER http://biocyc.org/getid?id=EcoCyc:G6447-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3447 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3447 EcoGene EG13683 http://www.ecogene.org/geneInfo.php?eg_id=EG13683 EnsemblBacteria AAC73940 http://www.ensemblgenomes.org/id/AAC73940 EnsemblBacteria AAC73940 http://www.ensemblgenomes.org/id/AAC73940 EnsemblBacteria BAA35564 http://www.ensemblgenomes.org/id/BAA35564 EnsemblBacteria BAA35564 http://www.ensemblgenomes.org/id/BAA35564 EnsemblBacteria BAA35564 http://www.ensemblgenomes.org/id/BAA35564 EnsemblBacteria b0853 http://www.ensemblgenomes.org/id/b0853 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0009297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009297 GO_process GO:0010212 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010212 GO_process GO:0030308 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030308 GO_process GO:1900232 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1900232 GO_process GO:1902201 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902201 GO_process GO:1902208 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902208 GO_process GO:1902209 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902209 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GeneID 945482 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945482 HOGENOM HOG000276367 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276367&db=HOGENOM6 InParanoid P0AAY6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAY6 IntAct P0AAY6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAY6* InterPro IPR019660 http://www.ebi.ac.uk/interpro/entry/IPR019660 KEGG_Gene ecj:JW0837 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0837 KEGG_Gene eco:b0853 http://www.genome.jp/dbget-bin/www_bget?eco:b0853 OMA SEEQVSM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SEEQVSM PSORT swissprot:YBJN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBJN_ECOLI PSORT-B swissprot:YBJN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBJN_ECOLI PSORT2 swissprot:YBJN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBJN_ECOLI Pfam PF10722 http://pfam.xfam.org/family/PF10722 Phobius swissprot:YBJN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBJN_ECOLI ProteinModelPortal P0AAY6 http://www.proteinmodelportal.org/query/uniprot/P0AAY6 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415374 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415374 RefSeq WP_000203025 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000203025 STRING 511145.b0853 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0853&targetmode=cogs UniProtKB YBJN_ECOLI http://www.uniprot.org/uniprot/YBJN_ECOLI UniProtKB-AC P0AAY6 http://www.uniprot.org/uniprot/P0AAY6 charge swissprot:YBJN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBJN_ECOLI eggNOG ENOG4108RMJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108RMJ eggNOG ENOG4111FKB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111FKB epestfind swissprot:YBJN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBJN_ECOLI garnier swissprot:YBJN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBJN_ECOLI helixturnhelix swissprot:YBJN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBJN_ECOLI hmoment swissprot:YBJN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBJN_ECOLI iep swissprot:YBJN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBJN_ECOLI inforesidue swissprot:YBJN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBJN_ECOLI octanol swissprot:YBJN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBJN_ECOLI pepcoil swissprot:YBJN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBJN_ECOLI pepdigest swissprot:YBJN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBJN_ECOLI pepinfo swissprot:YBJN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBJN_ECOLI pepnet swissprot:YBJN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBJN_ECOLI pepstats swissprot:YBJN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBJN_ECOLI pepwheel swissprot:YBJN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBJN_ECOLI pepwindow swissprot:YBJN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBJN_ECOLI sigcleave swissprot:YBJN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBJN_ECOLI ## Database ID URL or Descriptions # BioGrid 4260330 17 # CATALYTIC ACTIVITY YEAP_ECOLI 2 GTP = 2 diphosphate + cyclic di-3',5'- guanylate. # CDD cd01949 GGDEF # COFACTOR YEAP_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250}; Note=Binds 1 Mg(2+) ion per monomer. {ECO 0000250}; # DISRUPTION PHENOTYPE Decreased expression of CsgB, decreased curli expression at 28 degrees Celsius. {ECO:0000269|PubMed 19332833}. # EcoGene EG13502 yeaP # FUNCTION YEAP_ECOLI Catalyzes the condensation of two GTP molecules to the cyclic dinucleotide di-GMP (c-di-GMP), which acts as a secondary messenger (Probable). Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria. {ECO 0000269|PubMed 15716451, ECO 0000305}. # GO_function GO:0005525 GTP binding; IEA:UniProtKB-KW. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0052621 diguanylate cyclase activity; IDA:EcoCyc. # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0043167 ion binding # Gene3D 3.30.450.40 -; 1. # INDUCTION Expressed during exponential and post-exponential growth at both 28 and 37 degrees Celsius. {ECO:0000269|PubMed 19332833}. # IntAct P76245 3 # InterPro IPR000160 GGDEF_dom # InterPro IPR003018 GAF # InterPro IPR029016 GAF_dom-like # InterPro IPR029787 Nucleotide_cyclase # KEGG_Brite ko01000 Enzymes # Organism YEAP_ECOLI Escherichia coli (strain K12) # PATHWAY YEAP_ECOLI Purine metabolism; 3',5'-cyclic di-GMP biosynthesis. # PATRIC 32118901 VBIEscCol129921_1868 # PIR B64940 B64940 # PROSITE PS50887 GGDEF # Pfam PF00990 GGDEF # Pfam PF13185 GAF_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEAP_ECOLI Probable diguanylate cyclase YeaP # RefSeq NP_416308 NC_000913.3 # RefSeq WP_001310896 NZ_LN832404.1 # SIMILARITY Contains 1 GAF domain. {ECO 0000305}. # SIMILARITY Contains 1 GGDEF domain. {ECO:0000255|PROSITE- ProRule PRU00095}. # SMART SM00065 GAF # SMART SM00267 GGDEF # SUBUNIT Homodimer. {ECO 0000250}. # SUPFAM SSF55073 SSF55073 # SUPFAM SSF55781 SSF55781 # TIGRFAMs TIGR00254 GGDEF # eggNOG COG2203 LUCA # eggNOG ENOG410620I Bacteria BLAST swissprot:YEAP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEAP_ECOLI BioCyc ECOL316407:JW5292-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5292-MONOMER BioCyc EcoCyc:G6980-MONOMER http://biocyc.org/getid?id=EcoCyc:G6980-MONOMER BioCyc MetaCyc:G6980-MONOMER http://biocyc.org/getid?id=MetaCyc:G6980-MONOMER DIP DIP-11795N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11795N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1099/mic.0.024257-0 http://dx.doi.org/10.1099/mic.0.024257-0 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.187.5.1792-1798.2005 http://dx.doi.org/10.1128/JB.187.5.1792-1798.2005 EC_number EC:2.7.7.65 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.65 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.7.65 http://enzyme.expasy.org/EC/2.7.7.65 EchoBASE EB3275 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3275 EcoGene EG13502 http://www.ecogene.org/geneInfo.php?eg_id=EG13502 EnsemblBacteria AAC74864 http://www.ensemblgenomes.org/id/AAC74864 EnsemblBacteria AAC74864 http://www.ensemblgenomes.org/id/AAC74864 EnsemblBacteria BAA15592 http://www.ensemblgenomes.org/id/BAA15592 EnsemblBacteria BAA15592 http://www.ensemblgenomes.org/id/BAA15592 EnsemblBacteria BAA15592 http://www.ensemblgenomes.org/id/BAA15592 EnsemblBacteria b1794 http://www.ensemblgenomes.org/id/b1794 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0052621 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052621 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.30.450.40 http://www.cathdb.info/version/latest/superfamily/3.30.450.40 GeneID 948969 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948969 HOGENOM HOG000279862 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000279862&db=HOGENOM6 InParanoid P76245 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76245 IntAct P76245 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76245* IntEnz 2.7.7.65 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.65 InterPro IPR000160 http://www.ebi.ac.uk/interpro/entry/IPR000160 InterPro IPR003018 http://www.ebi.ac.uk/interpro/entry/IPR003018 InterPro IPR029016 http://www.ebi.ac.uk/interpro/entry/IPR029016 InterPro IPR029787 http://www.ebi.ac.uk/interpro/entry/IPR029787 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5292 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5292 KEGG_Gene eco:b1794 http://www.genome.jp/dbget-bin/www_bget?eco:b1794 KEGG_Orthology KO:K13069 http://www.genome.jp/dbget-bin/www_bget?KO:K13069 KEGG_Reaction rn:R08057 http://www.genome.jp/dbget-bin/www_bget?rn:R08057 MINT MINT-1321161 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1321161 OMA DTLCKRA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DTLCKRA PROSITE PS50887 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50887 PSORT swissprot:YEAP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEAP_ECOLI PSORT-B swissprot:YEAP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEAP_ECOLI PSORT2 swissprot:YEAP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEAP_ECOLI Pfam PF00990 http://pfam.xfam.org/family/PF00990 Pfam PF13185 http://pfam.xfam.org/family/PF13185 Phobius swissprot:YEAP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEAP_ECOLI PhylomeDB P76245 http://phylomedb.org/?seqid=P76245 ProteinModelPortal P76245 http://www.proteinmodelportal.org/query/uniprot/P76245 PubMed 15716451 http://www.ncbi.nlm.nih.gov/pubmed/15716451 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19332833 http://www.ncbi.nlm.nih.gov/pubmed/19332833 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416308 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416308 RefSeq WP_001310896 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001310896 SMART SM00065 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00065 SMART SM00267 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00267 SMR P76245 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76245 STRING 511145.b1794 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1794&targetmode=cogs SUPFAM SSF55073 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55073 SUPFAM SSF55781 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55781 TIGRFAMs TIGR00254 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00254 UniProtKB YEAP_ECOLI http://www.uniprot.org/uniprot/YEAP_ECOLI UniProtKB-AC P76245 http://www.uniprot.org/uniprot/P76245 charge swissprot:YEAP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEAP_ECOLI eggNOG COG2203 http://eggnogapi.embl.de/nog_data/html/tree/COG2203 eggNOG ENOG410620I http://eggnogapi.embl.de/nog_data/html/tree/ENOG410620I epestfind swissprot:YEAP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEAP_ECOLI garnier swissprot:YEAP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEAP_ECOLI helixturnhelix swissprot:YEAP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEAP_ECOLI hmoment swissprot:YEAP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEAP_ECOLI iep swissprot:YEAP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEAP_ECOLI inforesidue swissprot:YEAP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEAP_ECOLI octanol swissprot:YEAP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEAP_ECOLI pepcoil swissprot:YEAP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEAP_ECOLI pepdigest swissprot:YEAP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEAP_ECOLI pepinfo swissprot:YEAP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEAP_ECOLI pepnet swissprot:YEAP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEAP_ECOLI pepstats swissprot:YEAP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEAP_ECOLI pepwheel swissprot:YEAP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEAP_ECOLI pepwindow swissprot:YEAP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEAP_ECOLI sigcleave swissprot:YEAP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEAP_ECOLI ## Database ID URL or Descriptions # EcoGene EG14463 ymiA # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # INDUCTION Constitutively expressed (at protein level). {ECO:0000269|PubMed 19121005}. # IntAct P0CB62 3 # Organism YMIA_ECOLI Escherichia coli (strain K12) # PATRIC 32117810 VBIEscCol129921_1325 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YMIA_ECOLI Uncharacterized protein YmiA # RefSeq YP_588449 NC_000913.3 # SUBCELLULAR LOCATION YMIA_ECOLI Membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. BLAST swissprot:YMIA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YMIA_ECOLI BioCyc EcoCyc:MONOMER0-2885 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2885 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/mcp.M113.029165 http://dx.doi.org/10.1074/mcp.M113.029165 DOI 10.1111/j.1365-2958.2008.06495.x http://dx.doi.org/10.1111/j.1365-2958.2008.06495.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14463 http://www.ecogene.org/geneInfo.php?eg_id=EG14463 EnsemblBacteria ABD18655 http://www.ensemblgenomes.org/id/ABD18655 EnsemblBacteria ABD18655 http://www.ensemblgenomes.org/id/ABD18655 EnsemblBacteria b4522 http://www.ensemblgenomes.org/id/b4522 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GeneID 1450256 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1450256 HOGENOM HOG000267928 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267928&db=HOGENOM6 IntAct P0CB62 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0CB62* KEGG_Gene eco:b4522 http://www.genome.jp/dbget-bin/www_bget?eco:b4522 PSORT swissprot:YMIA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YMIA_ECOLI PSORT-B swissprot:YMIA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YMIA_ECOLI PSORT2 swissprot:YMIA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YMIA_ECOLI Phobius swissprot:YMIA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YMIA_ECOLI ProteinModelPortal P0CB62 http://www.proteinmodelportal.org/query/uniprot/P0CB62 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19121005 http://www.ncbi.nlm.nih.gov/pubmed/19121005 PubMed 23908556 http://www.ncbi.nlm.nih.gov/pubmed/23908556 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq YP_588449 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_588449 STRING 511145.b4522 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4522&targetmode=cogs UniProtKB YMIA_ECOLI http://www.uniprot.org/uniprot/YMIA_ECOLI UniProtKB-AC P0CB62 http://www.uniprot.org/uniprot/P0CB62 charge swissprot:YMIA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YMIA_ECOLI epestfind swissprot:YMIA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YMIA_ECOLI garnier swissprot:YMIA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YMIA_ECOLI helixturnhelix swissprot:YMIA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YMIA_ECOLI hmoment swissprot:YMIA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YMIA_ECOLI iep swissprot:YMIA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YMIA_ECOLI inforesidue swissprot:YMIA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YMIA_ECOLI octanol swissprot:YMIA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YMIA_ECOLI pepcoil swissprot:YMIA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YMIA_ECOLI pepdigest swissprot:YMIA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YMIA_ECOLI pepinfo swissprot:YMIA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YMIA_ECOLI pepnet swissprot:YMIA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YMIA_ECOLI pepstats swissprot:YMIA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YMIA_ECOLI pepwheel swissprot:YMIA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YMIA_ECOLI pepwindow swissprot:YMIA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YMIA_ECOLI sigcleave swissprot:YMIA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YMIA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261396 7 # EcoGene EG11877 uspD # FUNCTION USPD_ECOLI Required for resistance to DNA-damaging agents. {ECO 0000269|PubMed 11849540}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_process GO:0006950 response to stress; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_process GO:0006950 response to stress # Gene3D 3.40.50.620 -; 1. # INDUCTION During growth inhibition caused by the exhaustion of any of a variety of nutrients (carbon, nitrogen, phosphate, sulfate, required amino acid) or by the presence of a variety of toxic agents. Positively regulated by guanosine 3',5'-bisphosphate (ppGpp) and by a RecA/FtsK-dependent regulatory pathway. {ECO:0000269|PubMed 11849540}. # IntAct P0AAB8 6 # InterPro IPR006015 Universal_stress_UspA # InterPro IPR006016 UspA # InterPro IPR014729 Rossmann-like_a/b/a_fold # Organism USPD_ECOLI Escherichia coli (strain K12) # PATRIC 32123359 VBIEscCol129921_4040 # PIR S40866 S40866 # PIRSF PIRSF006276 UspA # Pfam PF00582 Usp # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName USPD_ECOLI Universal stress protein D # RefSeq NP_418358 NC_000913.3 # RefSeq WP_000323556 NZ_LN832404.1 # SIMILARITY Belongs to the universal stress protein A family. {ECO 0000305}. # SUBCELLULAR LOCATION USPD_ECOLI Cytoplasm {ECO 0000250}. # eggNOG COG0589 LUCA BLAST swissprot:USPD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:USPD_ECOLI BioCyc ECOL316407:JW3894-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3894-MONOMER BioCyc EcoCyc:EG11877-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11877-MONOMER COG COG0589 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0589 DIP DIP-35856N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35856N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2002.02720.x http://dx.doi.org/10.1046/j.1365-2958.2002.02720.x DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1823 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1823 EcoGene EG11877 http://www.ecogene.org/geneInfo.php?eg_id=EG11877 EnsemblBacteria AAC76905 http://www.ensemblgenomes.org/id/AAC76905 EnsemblBacteria AAC76905 http://www.ensemblgenomes.org/id/AAC76905 EnsemblBacteria BAE77387 http://www.ensemblgenomes.org/id/BAE77387 EnsemblBacteria BAE77387 http://www.ensemblgenomes.org/id/BAE77387 EnsemblBacteria BAE77387 http://www.ensemblgenomes.org/id/BAE77387 EnsemblBacteria b3923 http://www.ensemblgenomes.org/id/b3923 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 GeneID 948415 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948415 HOGENOM HOG000238899 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000238899&db=HOGENOM6 InParanoid P0AAB8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAB8 IntAct P0AAB8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAB8* InterPro IPR006015 http://www.ebi.ac.uk/interpro/entry/IPR006015 InterPro IPR006016 http://www.ebi.ac.uk/interpro/entry/IPR006016 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 KEGG_Gene ecj:JW3894 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3894 KEGG_Gene eco:b3923 http://www.genome.jp/dbget-bin/www_bget?eco:b3923 KEGG_Orthology KO:K14065 http://www.genome.jp/dbget-bin/www_bget?KO:K14065 OMA MAYKHIA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MAYKHIA PSORT swissprot:USPD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:USPD_ECOLI PSORT-B swissprot:USPD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:USPD_ECOLI PSORT2 swissprot:USPD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:USPD_ECOLI Pfam PF00582 http://pfam.xfam.org/family/PF00582 Phobius swissprot:USPD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:USPD_ECOLI PhylomeDB P0AAB8 http://phylomedb.org/?seqid=P0AAB8 ProteinModelPortal P0AAB8 http://www.proteinmodelportal.org/query/uniprot/P0AAB8 PubMed 11849540 http://www.ncbi.nlm.nih.gov/pubmed/11849540 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418358 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418358 RefSeq WP_000323556 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000323556 SMR P0AAB8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAB8 STRING 511145.b3923 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3923&targetmode=cogs STRING COG0589 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0589&targetmode=cogs UniProtKB USPD_ECOLI http://www.uniprot.org/uniprot/USPD_ECOLI UniProtKB-AC P0AAB8 http://www.uniprot.org/uniprot/P0AAB8 charge swissprot:USPD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:USPD_ECOLI eggNOG COG0589 http://eggnogapi.embl.de/nog_data/html/tree/COG0589 epestfind swissprot:USPD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:USPD_ECOLI garnier swissprot:USPD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:USPD_ECOLI helixturnhelix swissprot:USPD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:USPD_ECOLI hmoment swissprot:USPD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:USPD_ECOLI iep swissprot:USPD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:USPD_ECOLI inforesidue swissprot:USPD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:USPD_ECOLI octanol swissprot:USPD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:USPD_ECOLI pepcoil swissprot:USPD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:USPD_ECOLI pepdigest swissprot:USPD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:USPD_ECOLI pepinfo swissprot:USPD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:USPD_ECOLI pepnet swissprot:USPD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:USPD_ECOLI pepstats swissprot:USPD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:USPD_ECOLI pepwheel swissprot:USPD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:USPD_ECOLI pepwindow swissprot:USPD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:USPD_ECOLI sigcleave swissprot:USPD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:USPD_ECOLI ## Database ID URL or Descriptions # BioGrid 4260440 3 # EcoGene EG11998 yehL # GO_function GO:0005524 ATP binding; IEA:InterPro. # GO_function GO:0016887 ATPase activity; IEA:InterPro. # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.300 -; 1. # InterPro IPR003593 AAA+_ATPase # InterPro IPR011704 ATPase_dyneun-rel_AAA # InterPro IPR027417 P-loop_NTPase # Organism YEHL_ECOLI Escherichia coli (strain K12) # PATRIC 32119573 VBIEscCol129921_2197 # PIR F64979 F64979 # Pfam PF07728 AAA_5 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEHL_ECOLI Uncharacterized protein YehL # RefSeq NP_416623 NC_000913.3 # RefSeq WP_001350535 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA60480.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SMART SM00382 AAA # SUPFAM SSF52540 SSF52540 # eggNOG COG0714 LUCA # eggNOG ENOG4105KKX Bacteria BLAST swissprot:YEHL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEHL_ECOLI BioCyc ECOL316407:JW5349-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5349-MONOMER BioCyc EcoCyc:EG11998-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11998-MONOMER DIP DIP-11902N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11902N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1938 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1938 EcoGene EG11998 http://www.ecogene.org/geneInfo.php?eg_id=EG11998 EnsemblBacteria AAC75180 http://www.ensemblgenomes.org/id/AAC75180 EnsemblBacteria AAC75180 http://www.ensemblgenomes.org/id/AAC75180 EnsemblBacteria BAE76595 http://www.ensemblgenomes.org/id/BAE76595 EnsemblBacteria BAE76595 http://www.ensemblgenomes.org/id/BAE76595 EnsemblBacteria BAE76595 http://www.ensemblgenomes.org/id/BAE76595 EnsemblBacteria b2119 http://www.ensemblgenomes.org/id/b2119 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 946656 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946656 HOGENOM HOG000122177 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122177&db=HOGENOM6 InParanoid P33348 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33348 IntAct P33348 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33348* InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR011704 http://www.ebi.ac.uk/interpro/entry/IPR011704 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Gene ecj:JW5349 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5349 KEGG_Gene eco:b2119 http://www.genome.jp/dbget-bin/www_bget?eco:b2119 MINT MINT-1262596 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1262596 OMA SWLSEHL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SWLSEHL PSORT swissprot:YEHL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEHL_ECOLI PSORT-B swissprot:YEHL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEHL_ECOLI PSORT2 swissprot:YEHL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEHL_ECOLI Pfam PF07728 http://pfam.xfam.org/family/PF07728 Phobius swissprot:YEHL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEHL_ECOLI PhylomeDB P33348 http://phylomedb.org/?seqid=P33348 ProteinModelPortal P33348 http://www.proteinmodelportal.org/query/uniprot/P33348 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416623 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416623 RefSeq WP_001350535 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001350535 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P33348 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33348 STRING 511145.b2119 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2119&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB YEHL_ECOLI http://www.uniprot.org/uniprot/YEHL_ECOLI UniProtKB-AC P33348 http://www.uniprot.org/uniprot/P33348 charge swissprot:YEHL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEHL_ECOLI eggNOG COG0714 http://eggnogapi.embl.de/nog_data/html/tree/COG0714 eggNOG ENOG4105KKX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KKX epestfind swissprot:YEHL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEHL_ECOLI garnier swissprot:YEHL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEHL_ECOLI helixturnhelix swissprot:YEHL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEHL_ECOLI hmoment swissprot:YEHL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEHL_ECOLI iep swissprot:YEHL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEHL_ECOLI inforesidue swissprot:YEHL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEHL_ECOLI octanol swissprot:YEHL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEHL_ECOLI pepcoil swissprot:YEHL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEHL_ECOLI pepdigest swissprot:YEHL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEHL_ECOLI pepinfo swissprot:YEHL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEHL_ECOLI pepnet swissprot:YEHL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEHL_ECOLI pepstats swissprot:YEHL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEHL_ECOLI pepwheel swissprot:YEHL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEHL_ECOLI pepwindow swissprot:YEHL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEHL_ECOLI sigcleave swissprot:YEHL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEHL_ECOLI ## Database ID URL or Descriptions # AltName IDNT_ECOLI 5-keto-D-gluconate transporter # BioGrid 4262729 5 # DISRUPTION PHENOTYPE Reduced growth rate when grown on 5-keto-D- gluconate as sole carbon source. {ECO:0000269|PubMed 17088549}. # EcoGene EG12539 idnT # FUNCTION IDNT_ECOLI Transports L-idonate, D-gluconate and 5-keto-D- gluconate, from the periplasm across the inner membrane. {ECO 0000269|PubMed 17088549, ECO 0000269|PubMed 9658018}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0015128 gluconate transmembrane transporter activity; IMP:EcoCyc. # GO_function GO:0015568 L-idonate transmembrane transporter activity; IDA:EcoCyc. # GO_process GO:0008643 carbohydrate transport; IDA:EcoCyc. # GO_process GO:0015726 L-idonate transport; IDA:EcoCyc. # GO_process GO:0019521 D-gluconate metabolic process; IEA:UniProtKB-KW. # GO_process GO:0046183 L-idonate catabolic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006810 transport # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # INDUCTION Up-regulated by 5-keto-D-gluconate. {ECO:0000269|PubMed 17088549}. # InterPro IPR003474 Glcn_transporter # KEGG_Brite ko02000 Transporters # Organism IDNT_ECOLI Escherichia coli (strain K12) # PATHWAY IDNT_ECOLI Carbohydrate acid metabolism; L-idonate degradation. # PATRIC 32124103 VBIEscCol129921_4396 # PIR S56491 S56491 # PIRSF PIRSF002746 Gluconate_transporter # Pfam PF02447 GntP_permease # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName IDNT_ECOLI Gnt-II system L-idonate transporter # RefSeq NP_418686 NC_000913.3 # RefSeq WP_001128335 NZ_LN832404.1 # SIMILARITY Belongs to the GntP permease family. {ECO 0000305}. # SUBCELLULAR LOCATION IDNT_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.8.1:the gluconate h(+) symporter (gntp) family # TIGRFAMs TIGR00791 gntP # eggNOG COG2610 LUCA # eggNOG ENOG4105C6Z Bacteria BLAST swissprot:IDNT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:IDNT_ECOLI BioCyc ECOL316407:JW4222-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4222-MONOMER BioCyc EcoCyc:YJGT-MONOMER http://biocyc.org/getid?id=EcoCyc:YJGT-MONOMER BioCyc MetaCyc:YJGT-MONOMER http://biocyc.org/getid?id=MetaCyc:YJGT-MONOMER COG COG2610 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2610 DIP DIP-10014N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10014N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0603364103 http://dx.doi.org/10.1073/pnas.0603364103 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2428 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2428 EcoGene EG12539 http://www.ecogene.org/geneInfo.php?eg_id=EG12539 EnsemblBacteria AAC77222 http://www.ensemblgenomes.org/id/AAC77222 EnsemblBacteria AAC77222 http://www.ensemblgenomes.org/id/AAC77222 EnsemblBacteria BAE78262 http://www.ensemblgenomes.org/id/BAE78262 EnsemblBacteria BAE78262 http://www.ensemblgenomes.org/id/BAE78262 EnsemblBacteria BAE78262 http://www.ensemblgenomes.org/id/BAE78262 EnsemblBacteria b4265 http://www.ensemblgenomes.org/id/b4265 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015128 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015128 GO_function GO:0015568 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015568 GO_process GO:0008643 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008643 GO_process GO:0015726 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015726 GO_process GO:0019521 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019521 GO_process GO:0046183 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046183 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 948798 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948798 HOGENOM HOG000237115 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000237115&db=HOGENOM6 InParanoid P39344 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39344 IntAct P39344 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39344* InterPro IPR003474 http://www.ebi.ac.uk/interpro/entry/IPR003474 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW4222 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4222 KEGG_Gene eco:b4265 http://www.genome.jp/dbget-bin/www_bget?eco:b4265 KEGG_Orthology KO:K06157 http://www.genome.jp/dbget-bin/www_bget?KO:K06157 MINT MINT-1218744 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1218744 OMA ERVHWAM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ERVHWAM PSORT swissprot:IDNT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:IDNT_ECOLI PSORT-B swissprot:IDNT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:IDNT_ECOLI PSORT2 swissprot:IDNT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:IDNT_ECOLI Pfam PF02447 http://pfam.xfam.org/family/PF02447 Phobius swissprot:IDNT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:IDNT_ECOLI PhylomeDB P39344 http://phylomedb.org/?seqid=P39344 ProteinModelPortal P39344 http://www.proteinmodelportal.org/query/uniprot/P39344 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17088549 http://www.ncbi.nlm.nih.gov/pubmed/17088549 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9658018 http://www.ncbi.nlm.nih.gov/pubmed/9658018 RefSeq NP_418686 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418686 RefSeq WP_001128335 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001128335 STRING 511145.b4265 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4265&targetmode=cogs STRING COG2610 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2610&targetmode=cogs TCDB 2.A.8.1 http://www.tcdb.org/search/result.php?tc=2.A.8.1 TIGRFAMs TIGR00791 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00791 UniProtKB IDNT_ECOLI http://www.uniprot.org/uniprot/IDNT_ECOLI UniProtKB-AC P39344 http://www.uniprot.org/uniprot/P39344 charge swissprot:IDNT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:IDNT_ECOLI eggNOG COG2610 http://eggnogapi.embl.de/nog_data/html/tree/COG2610 eggNOG ENOG4105C6Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C6Z epestfind swissprot:IDNT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:IDNT_ECOLI garnier swissprot:IDNT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:IDNT_ECOLI helixturnhelix swissprot:IDNT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:IDNT_ECOLI hmoment swissprot:IDNT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:IDNT_ECOLI iep swissprot:IDNT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:IDNT_ECOLI inforesidue swissprot:IDNT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:IDNT_ECOLI octanol swissprot:IDNT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:IDNT_ECOLI pepcoil swissprot:IDNT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:IDNT_ECOLI pepdigest swissprot:IDNT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:IDNT_ECOLI pepinfo swissprot:IDNT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:IDNT_ECOLI pepnet swissprot:IDNT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:IDNT_ECOLI pepstats swissprot:IDNT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:IDNT_ECOLI pepwheel swissprot:IDNT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:IDNT_ECOLI pepwindow swissprot:IDNT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:IDNT_ECOLI sigcleave swissprot:IDNT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:IDNT_ECOLI ## Database ID URL or Descriptions # AltName FLGJ_ECOLI Muramidase FlgJ # BioGrid 4261020 118 # CAZy GH73 Glycoside Hydrolase Family 73 # EcoGene EG14272 flgJ # FUNCTION FLGJ_ECOLI Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space. {ECO 0000250}. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_function GO:0004040 amidase activity; IEA:InterPro. # GO_function GO:0016798 hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW. # GO_process GO:0008152 metabolic process; IEA:UniProtKB-KW. # GO_process GO:0044780 bacterial-type flagellum assembly; IEA:InterPro. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GO_process GO:0071973 bacterial-type flagellum-dependent cell motility; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_process GO:0008150 biological_process # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0048870 cell motility # GOslim_process GO:0071554 cell wall organization or biogenesis # IntAct P75942 11 # InterPro IPR002901 MGlyc_endo_b_GlcNAc-like_dom # InterPro IPR013377 FlaJ # InterPro IPR019301 Flagellar_prot_FlgJ_N # KEGG_Brite ko02035 Bacterial motility proteins # MISCELLANEOUS FLGJ_ECOLI Probably exported via the flagellum-specific export pathway. # Organism FLGJ_ECOLI Escherichia coli (strain K12) # PATRIC 32117403 VBIEscCol129921_1124 # PIR F64851 F64851 # Pfam PF01832 Glucosaminidase # Pfam PF10135 Rod-binding # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FLGJ_ECOLI Peptidoglycan hydrolase FlgJ # RefSeq NP_415599 NC_000913.3 # RefSeq WP_001295441 NZ_LN832404.1 # SIMILARITY In the C-terminal section; belongs to the glycosyl hydrolase 73 family. {ECO 0000305}. # SIMILARITY In the N-terminal section; belongs to the FlgJ family. {ECO 0000305}. # SMART SM00047 LYZ2 # SUBCELLULAR LOCATION FLGJ_ECOLI Periplasm {ECO 0000250}. # TIGRFAMs TIGR02541 flagell_FlgJ # eggNOG COG1705 LUCA # eggNOG COG3951 LUCA # eggNOG ENOG4108ZW7 Bacteria BLAST swissprot:FLGJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLGJ_ECOLI BioCyc ECOL316407:JW1068-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1068-MONOMER BioCyc EcoCyc:G366-MONOMER http://biocyc.org/getid?id=EcoCyc:G366-MONOMER COG COG1705 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1705 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.2.1.- http://www.genome.jp/dbget-bin/www_bget?EC:3.2.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.2.1.- http://enzyme.expasy.org/EC/3.2.1.- EchoBASE EB4020 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4020 EcoGene EG14272 http://www.ecogene.org/geneInfo.php?eg_id=EG14272 EnsemblBacteria AAC74165 http://www.ensemblgenomes.org/id/AAC74165 EnsemblBacteria AAC74165 http://www.ensemblgenomes.org/id/AAC74165 EnsemblBacteria BAA35890 http://www.ensemblgenomes.org/id/BAA35890 EnsemblBacteria BAA35890 http://www.ensemblgenomes.org/id/BAA35890 EnsemblBacteria BAA35890 http://www.ensemblgenomes.org/id/BAA35890 EnsemblBacteria b1081 http://www.ensemblgenomes.org/id/b1081 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0004040 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004040 GO_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GO_process GO:0008152 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008152 GO_process GO:0044780 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044780 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GO_process GO:0071973 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071973 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 GeneID 947456 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947456 HOGENOM HOG000265620 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000265620&db=HOGENOM6 InParanoid P75942 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75942 IntAct P75942 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75942* IntEnz 3.2.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.2.1 InterPro IPR002901 http://www.ebi.ac.uk/interpro/entry/IPR002901 InterPro IPR013377 http://www.ebi.ac.uk/interpro/entry/IPR013377 InterPro IPR019301 http://www.ebi.ac.uk/interpro/entry/IPR019301 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW1068 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1068 KEGG_Gene eco:b1081 http://www.genome.jp/dbget-bin/www_bget?eco:b1081 KEGG_Orthology KO:K02395 http://www.genome.jp/dbget-bin/www_bget?KO:K02395 OMA EGVFVQM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EGVFVQM PSORT swissprot:FLGJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLGJ_ECOLI PSORT-B swissprot:FLGJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLGJ_ECOLI PSORT2 swissprot:FLGJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLGJ_ECOLI Pfam PF01832 http://pfam.xfam.org/family/PF01832 Pfam PF10135 http://pfam.xfam.org/family/PF10135 Phobius swissprot:FLGJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLGJ_ECOLI ProteinModelPortal P75942 http://www.proteinmodelportal.org/query/uniprot/P75942 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415599 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415599 RefSeq WP_001295441 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295441 SMART SM00047 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00047 SMR P75942 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75942 STRING 511145.b1081 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1081&targetmode=cogs STRING COG1705 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1705&targetmode=cogs TIGRFAMs TIGR02541 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02541 UniProtKB FLGJ_ECOLI http://www.uniprot.org/uniprot/FLGJ_ECOLI UniProtKB-AC P75942 http://www.uniprot.org/uniprot/P75942 charge swissprot:FLGJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLGJ_ECOLI eggNOG COG1705 http://eggnogapi.embl.de/nog_data/html/tree/COG1705 eggNOG COG3951 http://eggnogapi.embl.de/nog_data/html/tree/COG3951 eggNOG ENOG4108ZW7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZW7 epestfind swissprot:FLGJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLGJ_ECOLI garnier swissprot:FLGJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLGJ_ECOLI helixturnhelix swissprot:FLGJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLGJ_ECOLI hmoment swissprot:FLGJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLGJ_ECOLI iep swissprot:FLGJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLGJ_ECOLI inforesidue swissprot:FLGJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLGJ_ECOLI octanol swissprot:FLGJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLGJ_ECOLI pepcoil swissprot:FLGJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLGJ_ECOLI pepdigest swissprot:FLGJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLGJ_ECOLI pepinfo swissprot:FLGJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLGJ_ECOLI pepnet swissprot:FLGJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLGJ_ECOLI pepstats swissprot:FLGJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLGJ_ECOLI pepwheel swissprot:FLGJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLGJ_ECOLI pepwindow swissprot:FLGJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLGJ_ECOLI sigcleave swissprot:FLGJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLGJ_ECOLI ## Database ID URL or Descriptions # AltName AROL_ECOLI Shikimate kinase II # BIOPHYSICOCHEMICAL PROPERTIES AROL_ECOLI Kinetic parameters KM=200 uM for shikimate {ECO 0000269|PubMed 3001029}; KM=160 uM for ATP {ECO 0000269|PubMed 3001029}; # BioGrid 4259831 2 # CATALYTIC ACTIVITY AROL_ECOLI ATP + shikimate = ADP + shikimate 3-phosphate. # CDD cd00464 SK # COFACTOR AROL_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 3001029}; Note=Binds 1 Mg(2+) ion per subunit. {ECO 0000269|PubMed 3001029}; # DOMAIN AROL_ECOLI The LID domain closes over the active site upon ATP binding. {ECO 0000250}. # EcoGene EG10082 aroL # FUNCTION AROL_ECOLI Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. {ECO 0000269|PubMed 3001029, ECO 0000269|PubMed 3026317}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0004765 shikimate kinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0046872 metal ion binding; IDA:EcoCyc. # GO_process GO:0008652 cellular amino acid biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0009073 aromatic amino acid family biosynthetic process; IMP:EcoliWiki. # GO_process GO:0009423 chorismate biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0019632 shikimate metabolic process; IBA:GO_Central. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.300 -; 1. # HAMAP MF_00109 Shikimate_kinase # HAMAP MF_01269 Shikimate_kinase_2 # INDUCTION AROL_ECOLI Expressed under the control of TyrR and TrpR repressors. {ECO 0000269|PubMed 1530846, ECO 0000269|PubMed 3001024, ECO 0000269|PubMed 7961453}. # IntAct P0A6E1 3 # InterPro IPR000623 Shikimate_kinase/TSH1 # InterPro IPR023000 Shikimate_kinase_CS # InterPro IPR027417 P-loop_NTPase # InterPro IPR027544 Shikimate_kinase_2 # InterPro IPR031322 Shikimate/glucono_kinase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis # MISCELLANEOUS AROL_ECOLI Two isozymes have been found in E.coli. AroK has 100-fold lower affinity for shikimate than AroL, suggesting that AroL is the dominant enzyme in the biosynthesis of the aromatic amino acids, with AroK playing a secondary role and possibly participating in an as yet unidentified cellular process. # Organism AROL_ECOLI Escherichia coli (strain K12) # PATHWAY Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate step 5/7. # PATRIC 32115917 VBIEscCol129921_0400 # PIR A90333 KIECS # PROSITE PS01128 SHIKIMATE_KINASE # Pfam PF01202 SKI # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AROL_ECOLI Shikimate kinase 2 # RefSeq NP_414922 NC_000913.3 # RefSeq WP_000193393 NZ_LN832404.1 # SIMILARITY Belongs to the shikimate kinase family. AroL subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION AROL_ECOLI Cytoplasm {ECO 0000250}. # SUBUNIT Monomer. {ECO:0000269|PubMed 3026317}. # SUPFAM SSF52540 SSF52540 # UniPathway UPA00053 UER00088 # eggNOG COG0703 LUCA # eggNOG ENOG4105KHV Bacteria BLAST swissprot:AROL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AROL_ECOLI BioCyc ECOL316407:JW0379-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0379-MONOMER BioCyc EcoCyc:AROL-MONOMER http://biocyc.org/getid?id=EcoCyc:AROL-MONOMER BioCyc MetaCyc:AROL-MONOMER http://biocyc.org/getid?id=MetaCyc:AROL-MONOMER COG COG0703 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0703 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2370427 http://dx.doi.org/10.1042/bj2370427 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.71 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.71 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M13045 http://www.ebi.ac.uk/ena/data/view/M13045 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EMBL X04064 http://www.ebi.ac.uk/ena/data/view/X04064 ENZYME 2.7.1.71 http://enzyme.expasy.org/EC/2.7.1.71 EchoBASE EB0080 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0080 EcoGene EG10082 http://www.ecogene.org/geneInfo.php?eg_id=EG10082 EnsemblBacteria AAC73491 http://www.ensemblgenomes.org/id/AAC73491 EnsemblBacteria AAC73491 http://www.ensemblgenomes.org/id/AAC73491 EnsemblBacteria BAE76169 http://www.ensemblgenomes.org/id/BAE76169 EnsemblBacteria BAE76169 http://www.ensemblgenomes.org/id/BAE76169 EnsemblBacteria BAE76169 http://www.ensemblgenomes.org/id/BAE76169 EnsemblBacteria b0388 http://www.ensemblgenomes.org/id/b0388 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0004765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004765 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0008652 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008652 GO_process GO:0009073 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009073 GO_process GO:0009423 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009423 GO_process GO:0019632 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019632 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945031 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945031 HAMAP MF_00109 http://hamap.expasy.org/unirule/MF_00109 HAMAP MF_01269 http://hamap.expasy.org/unirule/MF_01269 HOGENOM HOG000032568 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000032568&db=HOGENOM6 InParanoid P0A6E1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6E1 IntAct P0A6E1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6E1* IntEnz 2.7.1.71 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.71 InterPro IPR000623 http://www.ebi.ac.uk/interpro/entry/IPR000623 InterPro IPR023000 http://www.ebi.ac.uk/interpro/entry/IPR023000 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR027544 http://www.ebi.ac.uk/interpro/entry/IPR027544 InterPro IPR031322 http://www.ebi.ac.uk/interpro/entry/IPR031322 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0379 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0379 KEGG_Gene eco:b0388 http://www.genome.jp/dbget-bin/www_bget?eco:b0388 KEGG_Orthology KO:K00891 http://www.genome.jp/dbget-bin/www_bget?KO:K00891 KEGG_Pathway ko00400 http://www.genome.jp/kegg-bin/show_pathway?ko00400 KEGG_Reaction rn:R02412 http://www.genome.jp/dbget-bin/www_bget?rn:R02412 OMA IFLVGPR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IFLVGPR PROSITE PS01128 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01128 PSORT swissprot:AROL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AROL_ECOLI PSORT-B swissprot:AROL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AROL_ECOLI PSORT2 swissprot:AROL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AROL_ECOLI Pfam PF01202 http://pfam.xfam.org/family/PF01202 Phobius swissprot:AROL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AROL_ECOLI PhylomeDB P0A6E1 http://phylomedb.org/?seqid=P0A6E1 ProteinModelPortal P0A6E1 http://www.proteinmodelportal.org/query/uniprot/P0A6E1 PubMed 1530846 http://www.ncbi.nlm.nih.gov/pubmed/1530846 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3001024 http://www.ncbi.nlm.nih.gov/pubmed/3001024 PubMed 3001025 http://www.ncbi.nlm.nih.gov/pubmed/3001025 PubMed 3001029 http://www.ncbi.nlm.nih.gov/pubmed/3001029 PubMed 3026317 http://www.ncbi.nlm.nih.gov/pubmed/3026317 PubMed 7961453 http://www.ncbi.nlm.nih.gov/pubmed/7961453 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414922 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414922 RefSeq WP_000193393 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000193393 SMR P0A6E1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6E1 STRING 511145.b0388 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0388&targetmode=cogs STRING COG0703 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0703&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB AROL_ECOLI http://www.uniprot.org/uniprot/AROL_ECOLI UniProtKB-AC P0A6E1 http://www.uniprot.org/uniprot/P0A6E1 charge swissprot:AROL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AROL_ECOLI eggNOG COG0703 http://eggnogapi.embl.de/nog_data/html/tree/COG0703 eggNOG ENOG4105KHV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KHV epestfind swissprot:AROL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AROL_ECOLI garnier swissprot:AROL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AROL_ECOLI helixturnhelix swissprot:AROL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AROL_ECOLI hmoment swissprot:AROL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AROL_ECOLI iep swissprot:AROL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AROL_ECOLI inforesidue swissprot:AROL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AROL_ECOLI octanol swissprot:AROL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AROL_ECOLI pepcoil swissprot:AROL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AROL_ECOLI pepdigest swissprot:AROL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AROL_ECOLI pepinfo swissprot:AROL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AROL_ECOLI pepnet swissprot:AROL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AROL_ECOLI pepstats swissprot:AROL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AROL_ECOLI pepwheel swissprot:AROL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AROL_ECOLI pepwindow swissprot:AROL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AROL_ECOLI sigcleave swissprot:AROL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AROL_ECOLI ## Database ID URL or Descriptions # AltName FDHF_ECOLI Formate dehydrogenase-H subunit alpha # AltName FDHF_ECOLI Formate-hydrogen-lyase-linked, selenocysteine-containing polypeptide # BRENDA 1.1.99.33 2026 # BRENDA 1.2.1 2026 # BioGrid 4262950 9 # CATALYTIC ACTIVITY FDHF_ECOLI Formate + NAD(+) = CO(2) + NADH. # CATALYTIC ACTIVITY FDHF_ECOLI Formate + acceptor = CO(2) + reduced acceptor. # COFACTOR Name=Mo-bis(molybdopterin guanine dinucleotide); Xref=ChEBI:CHEBI 60539; Note=Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.; # COFACTOR Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI 49883; Note=Binds 1 [4Fe-4S] cluster per subunit.; # ENZYME REGULATION FDHF_ECOLI Inhibited by aerobic conditions. {ECO 0000269|PubMed 8626495, ECO 0000269|PubMed 9521673}. # EcoGene EG10285 fdhF # FUNCTION FDHF_ECOLI Decomposes formic acid to hydrogen and carbon dioxide under anaerobic conditions in the absence of exogenous electron acceptors. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008863 formate dehydrogenase (NAD+) activity; IEA:UniProtKB-EC. # GO_function GO:0009055 electron carrier activity; IEA:InterPro. # GO_function GO:0030151 molybdenum ion binding; IDA:EcoCyc. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IDA:EcoCyc. # GO_process GO:0015944 formate oxidation; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0044281 small molecule metabolic process # INDUCTION FDHF_ECOLI By formate. Repressed by oxygen, nitrate, nitrite, and other electron acceptors. # INTERACTION FDHF_ECOLI P16433 hycG; NbExp=3; IntAct=EBI-1121603, EBI-541977; # IntAct P07658 13 # InterPro IPR006478 Formate_DH_asu # InterPro IPR006655 Mopterin_OxRdtase_prok_CS # InterPro IPR006656 Mopterin_OxRdtase # InterPro IPR006657 MoPterin_dinucl-bd_dom # InterPro IPR006963 Mopterin_OxRdtase_4Fe-4S_dom # InterPro IPR009010 Asp_de-COase-like_dom # InterPro IPR027467 MopterinOxRdtase_cofactor_BS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00630 Glyoxylate and dicarboxylate metabolism # KEGG_Pathway ko00680 Methane metabolism # Organism FDHF_ECOLI Escherichia coli (strain K12) # PATRIC 32123709 VBIEscCol129921_4203 # PDB 1AA6 X-ray; 2.30 A; A=1-715 # PDB 1FDI X-ray; 2.90 A; A=1-715 # PDB 1FDO X-ray; 2.80 A; A=1-715 # PDB 2IV2 X-ray; 2.27 A; X=1-715 # PIR A24145 DEECFS # PROSITE PS00490 MOLYBDOPTERIN_PROK_2 # PROSITE PS00551 MOLYBDOPTERIN_PROK_1 # PROSITE PS00932 MOLYBDOPTERIN_PROK_3 # PROSITE PS51669 4FE4S_MOW_BIS_MGD # Pfam PF00384 Molybdopterin # Pfam PF01568 Molydop_binding # Pfam PF04879 Molybdop_Fe4S4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FDHF_ECOLI Formate dehydrogenase H # RefSeq NP_418503 NC_000913.3 # SIMILARITY Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. {ECO 0000305}. # SIMILARITY Contains 1 4Fe-4S Mo/W bis-MGD-type domain. {ECO:0000255|PROSITE-ProRule PRU01004}. # SMART SM00926 Molybdop_Fe4S4 # SUBUNIT FDHF_ECOLI Consists of two separable enzymatic activities a formate dehydrogenase component (FDH-H) and hydrogenase-3. {ECO 0000269|PubMed 16830149, ECO 0000269|PubMed 9036855}. # SUPFAM SSF50692 SSF50692 # TCDB 3.D.1.9 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family # TIGRFAMs TIGR01591 Fdh-alpha # eggNOG COG0243 LUCA # eggNOG ENOG4107QIW Bacteria BLAST swissprot:FDHF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FDHF_ECOLI BioCyc ECOL316407:JW4040-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4040-MONOMER BioCyc EcoCyc:FORMATEDEHYDROGH-MONOMER http://biocyc.org/getid?id=EcoCyc:FORMATEDEHYDROGH-MONOMER BioCyc MetaCyc:FORMATEDEHYDROGH-MONOMER http://biocyc.org/getid?id=MetaCyc:FORMATEDEHYDROGH-MONOMER COG COG0243 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0243 DIP DIP-9572N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9572N DOI 10.1007/s00775-006-0129-2 http://dx.doi.org/10.1007/s00775-006-0129-2 DOI 10.1021/bi972177k http://dx.doi.org/10.1021/bi972177k DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.83.13.4650 http://dx.doi.org/10.1073/pnas.83.13.4650 DOI 10.1074/jbc.271.14.8095 http://dx.doi.org/10.1074/jbc.271.14.8095 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.275.5304.1305 http://dx.doi.org/10.1126/science.275.5304.1305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.99.33 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.99.33 EC_number EC:1.2.1.2 http://www.genome.jp/dbget-bin/www_bget?EC:1.2.1.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M13563 http://www.ebi.ac.uk/ena/data/view/M13563 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.1.99.33 http://enzyme.expasy.org/EC/1.1.99.33 ENZYME 1.2.1.2 http://enzyme.expasy.org/EC/1.2.1.2 EchoBASE EB0281 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0281 EcoGene EG10285 http://www.ecogene.org/geneInfo.php?eg_id=EG10285 EnsemblBacteria AAD13462 http://www.ensemblgenomes.org/id/AAD13462 EnsemblBacteria AAD13462 http://www.ensemblgenomes.org/id/AAD13462 EnsemblBacteria BAE78081 http://www.ensemblgenomes.org/id/BAE78081 EnsemblBacteria BAE78081 http://www.ensemblgenomes.org/id/BAE78081 EnsemblBacteria BAE78081 http://www.ensemblgenomes.org/id/BAE78081 EnsemblBacteria b4079 http://www.ensemblgenomes.org/id/b4079 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008863 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008863 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0030151 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030151 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0015944 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015944 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 948584 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948584 HOGENOM HOG000031440 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000031440&db=HOGENOM6 InParanoid P07658 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P07658 IntAct P07658 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P07658* IntEnz 1.1.99.33 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.99.33 IntEnz 1.2.1.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.2.1.2 InterPro IPR006478 http://www.ebi.ac.uk/interpro/entry/IPR006478 InterPro IPR006655 http://www.ebi.ac.uk/interpro/entry/IPR006655 InterPro IPR006656 http://www.ebi.ac.uk/interpro/entry/IPR006656 InterPro IPR006657 http://www.ebi.ac.uk/interpro/entry/IPR006657 InterPro IPR006963 http://www.ebi.ac.uk/interpro/entry/IPR006963 InterPro IPR009010 http://www.ebi.ac.uk/interpro/entry/IPR009010 InterPro IPR027467 http://www.ebi.ac.uk/interpro/entry/IPR027467 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4040 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4040 KEGG_Gene eco:b4079 http://www.genome.jp/dbget-bin/www_bget?eco:b4079 KEGG_Orthology KO:K00123 http://www.genome.jp/dbget-bin/www_bget?KO:K00123 KEGG_Pathway ko00630 http://www.genome.jp/kegg-bin/show_pathway?ko00630 KEGG_Pathway ko00680 http://www.genome.jp/kegg-bin/show_pathway?ko00680 KEGG_Reaction rn:R00519 http://www.genome.jp/dbget-bin/www_bget?rn:R00519 OMA WGVTLQP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WGVTLQP PDB 1AA6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1AA6 PDB 1FDI http://www.ebi.ac.uk/pdbe-srv/view/entry/1FDI PDB 1FDO http://www.ebi.ac.uk/pdbe-srv/view/entry/1FDO PDB 2IV2 http://www.ebi.ac.uk/pdbe-srv/view/entry/2IV2 PDBsum 1AA6 http://www.ebi.ac.uk/pdbsum/1AA6 PDBsum 1FDI http://www.ebi.ac.uk/pdbsum/1FDI PDBsum 1FDO http://www.ebi.ac.uk/pdbsum/1FDO PDBsum 2IV2 http://www.ebi.ac.uk/pdbsum/2IV2 PROSITE PS00490 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00490 PROSITE PS00551 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00551 PROSITE PS00932 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00932 PROSITE PS51669 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51669 PSORT swissprot:FDHF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FDHF_ECOLI PSORT-B swissprot:FDHF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FDHF_ECOLI PSORT2 swissprot:FDHF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FDHF_ECOLI Pfam PF00384 http://pfam.xfam.org/family/PF00384 Pfam PF01568 http://pfam.xfam.org/family/PF01568 Pfam PF04879 http://pfam.xfam.org/family/PF04879 Phobius swissprot:FDHF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FDHF_ECOLI PhylomeDB P07658 http://phylomedb.org/?seqid=P07658 ProteinModelPortal P07658 http://www.proteinmodelportal.org/query/uniprot/P07658 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16830149 http://www.ncbi.nlm.nih.gov/pubmed/16830149 PubMed 2211698 http://www.ncbi.nlm.nih.gov/pubmed/2211698 PubMed 2941757 http://www.ncbi.nlm.nih.gov/pubmed/2941757 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 8626495 http://www.ncbi.nlm.nih.gov/pubmed/8626495 PubMed 9036855 http://www.ncbi.nlm.nih.gov/pubmed/9036855 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9521673 http://www.ncbi.nlm.nih.gov/pubmed/9521673 RefSeq NP_418503 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418503 SMART SM00926 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00926 SMR P07658 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P07658 STRING 511145.b4079 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4079&targetmode=cogs STRING COG0243 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0243&targetmode=cogs SUPFAM SSF50692 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50692 TCDB 3.D.1.9 http://www.tcdb.org/search/result.php?tc=3.D.1.9 TIGRFAMs TIGR01591 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01591 UniProtKB FDHF_ECOLI http://www.uniprot.org/uniprot/FDHF_ECOLI UniProtKB-AC P07658 http://www.uniprot.org/uniprot/P07658 charge swissprot:FDHF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FDHF_ECOLI eggNOG COG0243 http://eggnogapi.embl.de/nog_data/html/tree/COG0243 eggNOG ENOG4107QIW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QIW epestfind swissprot:FDHF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FDHF_ECOLI garnier swissprot:FDHF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FDHF_ECOLI helixturnhelix swissprot:FDHF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FDHF_ECOLI hmoment swissprot:FDHF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FDHF_ECOLI iep swissprot:FDHF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FDHF_ECOLI inforesidue swissprot:FDHF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FDHF_ECOLI octanol swissprot:FDHF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FDHF_ECOLI pepcoil swissprot:FDHF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FDHF_ECOLI pepdigest swissprot:FDHF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FDHF_ECOLI pepinfo swissprot:FDHF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FDHF_ECOLI pepnet swissprot:FDHF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FDHF_ECOLI pepstats swissprot:FDHF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FDHF_ECOLI pepwheel swissprot:FDHF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FDHF_ECOLI pepwindow swissprot:FDHF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FDHF_ECOLI sigcleave swissprot:FDHF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FDHF_ECOLI ## Database ID URL or Descriptions # AltName L-fuculose kinase {ECO:0000255|HAMAP-Rule MF_00986} # BIOPHYSICOCHEMICAL PROPERTIES pH dependence: Optimum pH is 7.8. {ECO 0000269|PubMed:13905785}; # BioGrid 4259225 22 # CATALYTIC ACTIVITY FUCK_ECOLI ATP + L-fuculose = ADP + L-fuculose 1- phosphate. {ECO 0000255|HAMAP-Rule MF_00986, ECO 0000269|PubMed 13905785}. # COFACTOR FUCK_ECOLI Name=a divalent metal cation; Xref=ChEBI CHEBI 60240; Evidence={ECO 0000255|HAMAP-Rule MF_00986, ECO 0000269|PubMed 13905785}; # EcoGene EG10350 fucK # FUNCTION FUCK_ECOLI Catalyzes the phosphorylation of L-fuculose. Can also phosphorylate, with lower efficiency, D-ribulose, D-xylulose and D-fructose. {ECO 0000255|HAMAP-Rule MF_00986, ECO 0000269|PubMed 13905785}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008737 L-fuculokinase activity; IDA:EcoCyc. # GO_process GO:0019571 D-arabinose catabolic process; IMP:EcoCyc. # GO_process GO:0042355 L-fucose catabolic process; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # HAMAP MF_00986 Fuculokinase # IntAct P11553 4 # InterPro IPR000577 Carb_kinase_FGGY # InterPro IPR013450 Fuculokinase # InterPro IPR018483 Carb_kinase_FGGY_CS # InterPro IPR018484 Carb_kinase_FGGY_N # InterPro IPR018485 Carb_kinase_FGGY_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00051 Fructose and mannose metabolism # Organism FUCK_ECOLI Escherichia coli (strain K12) # PATHWAY FUCK_ECOLI Carbohydrate degradation; L-fucose degradation; L- lactaldehyde and glycerone phosphate from L-fucose step 2/3. {ECO 0000255|HAMAP-Rule MF_00986, ECO 0000269|PubMed 13905785}. # PATRIC 32121022 VBIEscCol129921_2903 # PIR JS0186 KIECFK # PIRSF PIRSF000538 GlpK # PROSITE PS00445 FGGY_KINASES_2 # PROSITE PS00933 FGGY_KINASES_1 # Pfam PF00370 FGGY_N # Pfam PF02782 FGGY_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName L-fuculokinase {ECO:0000255|HAMAP-Rule MF_00986} # RefSeq NP_417283 NC_000913.3 # SEQUENCE CAUTION Sequence=AAC75845.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the FGGY kinase family. {ECO:0000255|HAMAP- Rule MF_00986}. # TIGRFAMs TIGR02628 fuculo_kin_coli # UniPathway UPA00563 UER00625 # eggNOG COG1070 LUCA # eggNOG ENOG4105CMG Bacteria BLAST swissprot:FUCK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FUCK_ECOLI BioCyc ECOL316407:JW2774-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2774-MONOMER BioCyc EcoCyc:FUCULOKIN-MONOMER http://biocyc.org/getid?id=EcoCyc:FUCULOKIN-MONOMER BioCyc MetaCyc:FUCULOKIN-MONOMER http://biocyc.org/getid?id=MetaCyc:FUCULOKIN-MONOMER COG COG1070 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1070 DIP DIP-9712N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9712N DOI 10.1002/elps.1150191114 http://dx.doi.org/10.1002/elps.1150191114 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/17.12.4883 http://dx.doi.org/10.1093/nar/17.12.4883 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.51 {ECO:0000255|HAMAP-Rule:MF_00986} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.51 {ECO:0000255|HAMAP-Rule:MF_00986} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 EMBL X15025 http://www.ebi.ac.uk/ena/data/view/X15025 ENZYME 2.7.1.51 {ECO:0000255|HAMAP-Rule:MF_00986} http://enzyme.expasy.org/EC/2.7.1.51 {ECO:0000255|HAMAP-Rule:MF_00986} EchoBASE EB0346 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0346 EcoGene EG10350 http://www.ecogene.org/geneInfo.php?eg_id=EG10350 EnsemblBacteria AAC75845 http://www.ensemblgenomes.org/id/AAC75845 EnsemblBacteria AAC75845 http://www.ensemblgenomes.org/id/AAC75845 EnsemblBacteria BAE76875 http://www.ensemblgenomes.org/id/BAE76875 EnsemblBacteria BAE76875 http://www.ensemblgenomes.org/id/BAE76875 EnsemblBacteria BAE76875 http://www.ensemblgenomes.org/id/BAE76875 EnsemblBacteria b2803 http://www.ensemblgenomes.org/id/b2803 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008737 GO_process GO:0019571 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019571 GO_process GO:0042355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042355 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 946022 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946022 HAMAP MF_00986 http://hamap.expasy.org/unirule/MF_00986 HOGENOM HOG000124178 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000124178&db=HOGENOM6 InParanoid P11553 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P11553 IntAct P11553 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P11553* IntEnz 2.7.1.51 {ECO:0000255|HAMAP-Rule:MF_00986} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.51 {ECO:0000255|HAMAP-Rule:MF_00986} InterPro IPR000577 http://www.ebi.ac.uk/interpro/entry/IPR000577 InterPro IPR013450 http://www.ebi.ac.uk/interpro/entry/IPR013450 InterPro IPR018483 http://www.ebi.ac.uk/interpro/entry/IPR018483 InterPro IPR018484 http://www.ebi.ac.uk/interpro/entry/IPR018484 InterPro IPR018485 http://www.ebi.ac.uk/interpro/entry/IPR018485 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2774 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2774 KEGG_Gene eco:b2803 http://www.genome.jp/dbget-bin/www_bget?eco:b2803 KEGG_Orthology KO:K00879 http://www.genome.jp/dbget-bin/www_bget?KO:K00879 KEGG_Pathway ko00051 http://www.genome.jp/kegg-bin/show_pathway?ko00051 KEGG_Reaction rn:R03241 http://www.genome.jp/dbget-bin/www_bget?rn:R03241 MINT MINT-1305054 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1305054 PROSITE PS00445 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00445 PROSITE PS00933 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00933 PSORT swissprot:FUCK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FUCK_ECOLI PSORT-B swissprot:FUCK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FUCK_ECOLI PSORT2 swissprot:FUCK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FUCK_ECOLI Pfam PF00370 http://pfam.xfam.org/family/PF00370 Pfam PF02782 http://pfam.xfam.org/family/PF02782 Phobius swissprot:FUCK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FUCK_ECOLI PhylomeDB P11553 http://phylomedb.org/?seqid=P11553 ProteinModelPortal P11553 http://www.proteinmodelportal.org/query/uniprot/P11553 PubMed 13905785 http://www.ncbi.nlm.nih.gov/pubmed/13905785 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2664711 http://www.ncbi.nlm.nih.gov/pubmed/2664711 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9740056 http://www.ncbi.nlm.nih.gov/pubmed/9740056 RefSeq NP_417283 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417283 SMR P11553 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P11553 STRING 511145.b2803 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2803&targetmode=cogs STRING COG1070 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1070&targetmode=cogs SWISS-2DPAGE P11553 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P11553 TIGRFAMs TIGR02628 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02628 UniProtKB FUCK_ECOLI http://www.uniprot.org/uniprot/FUCK_ECOLI UniProtKB-AC P11553 http://www.uniprot.org/uniprot/P11553 charge swissprot:FUCK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FUCK_ECOLI eggNOG COG1070 http://eggnogapi.embl.de/nog_data/html/tree/COG1070 eggNOG ENOG4105CMG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CMG epestfind swissprot:FUCK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FUCK_ECOLI garnier swissprot:FUCK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FUCK_ECOLI helixturnhelix swissprot:FUCK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FUCK_ECOLI hmoment swissprot:FUCK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FUCK_ECOLI iep swissprot:FUCK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FUCK_ECOLI inforesidue swissprot:FUCK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FUCK_ECOLI octanol swissprot:FUCK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FUCK_ECOLI pepcoil swissprot:FUCK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FUCK_ECOLI pepdigest swissprot:FUCK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FUCK_ECOLI pepinfo swissprot:FUCK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FUCK_ECOLI pepnet swissprot:FUCK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FUCK_ECOLI pepstats swissprot:FUCK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FUCK_ECOLI pepwheel swissprot:FUCK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FUCK_ECOLI pepwindow swissprot:FUCK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FUCK_ECOLI sigcleave swissprot:FUCK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FUCK_ECOLI ## Database ID URL or Descriptions # AltName GGT_ECOLI Glutathione hydrolase # BRENDA 2.3.2 2026 # BRENDA 3.4.19.13 2026 # BioGrid 4261666 368 # CATALYTIC ACTIVITY A (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid. {ECO:0000269|PubMed 1360205}. # CATALYTIC ACTIVITY Glutathione + H(2)O = L-cysteinylglycine + L- glutamate. {ECO:0000250|UniProtKB P54422}. # EcoGene EG10374 ggt # GO_component GO:0042597 periplasmic space; IDA:EcoliWiki. # GO_function GO:0003840 gamma-glutamyltransferase activity; IDA:EcoliWiki. # GO_function GO:0036374 glutathione hydrolase activity; IEA:UniProtKB-EC. # GO_process GO:0006750 glutathione biosynthetic process; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # InterPro IPR000101 GGT_peptidase # InterPro IPR029055 Ntn_hydrolases_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # KEGG_Brite ko04090 Cellular antigens # KEGG_Pathway ko00430 Taurine and hypotaurine metabolism # KEGG_Pathway ko00460 Cyanoamino acid metabolism # KEGG_Pathway ko00480 Glutathione metabolism # KEGG_Pathway ko00590 Arachidonic acid metabolism # Organism GGT_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11686 PTHR11686 # PATHWAY GGT_ECOLI Sulfur metabolism; glutathione metabolism. # PATRIC 32122334 VBIEscCol129921_3544 # PDB 2DBU X-ray; 1.95 A; A/C=25-390, B/D=391-580 # PDB 2DBW X-ray; 1.80 A; A/C=25-390, B/D=391-580 # PDB 2DBX X-ray; 1.70 A; A/C=25-390, B/D=391-580 # PDB 2DG5 X-ray; 1.60 A; A/C=25-390, B/D=391-580 # PDB 2E0W X-ray; 2.55 A; A/B=25-580 # PDB 2E0X X-ray; 1.95 A; A/C=25-390, B/D=391-580 # PDB 2E0Y X-ray; 2.02 A; A/C=25-390, B/D=391-580 # PDB 2Z8I X-ray; 1.65 A; A/C=25-390, B/D=391-580 # PDB 2Z8J X-ray; 2.05 A; A/C=25-390, B/D=391-580 # PDB 2Z8K X-ray; 1.65 A; A/C=25-390, B/D=391-580 # PDB 5B5T X-ray; 1.70 A; A/C=25-390, B/D=391-580 # PIR JV0028 EKECEX # PRINTS PR01210 GGTRANSPTASE # PROSITE PS00462 G_GLU_TRANSPEPTIDASE # PTM GGT_ECOLI Cleaved by autocatalysis into a large and a small subunit. # Pfam PF01019 G_glu_transpept # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GGT_ECOLI Gamma-glutamyltranspeptidase large chain # RecName GGT_ECOLI Gamma-glutamyltranspeptidase large chain # RecName GGT_ECOLI Gamma-glutamyltranspeptidase small chain # RecName Gamma-glutamyltranspeptidase {ECO:0000303|PubMed 2570061} # RefSeq NP_417904 NC_000913.3 # RefSeq WP_000595082 NZ_LN832404.1 # SIMILARITY Belongs to the gamma-glutamyltransferase family. {ECO 0000305}. # SUBCELLULAR LOCATION GGT_ECOLI Periplasm {ECO 0000269|PubMed 1360205}. # SUBUNIT GGT_ECOLI This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide. {ECO 0000269|PubMed 1360205, ECO 0000269|PubMed 16618936, ECO 0000269|PubMed 17135273, ECO 0000269|PubMed 18555071}. # SUPFAM SSF56235 SSF56235 # TIGRFAMs TIGR00066 g_glut_trans # eggNOG COG0405 LUCA # eggNOG ENOG4105CFB Bacteria BLAST swissprot:GGT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GGT_ECOLI BioCyc ECOL316407:JW3412-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3412-MONOMER BioCyc EcoCyc:EG10374-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10374-MONOMER BioCyc MetaCyc:EG10374-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10374-MONOMER COG COG0405 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0405 DIP DIP-9758N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9758N DOI 10.1016/0006-291X(92)91540-7 http://dx.doi.org/10.1016/0006-291X(92)91540-7 DOI 10.1016/j.jmb.2008.05.007 http://dx.doi.org/10.1016/j.jmb.2008.05.007 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0511020103 http://dx.doi.org/10.1073/pnas.0511020103 DOI 10.1074/jbc.M607490200 http://dx.doi.org/10.1074/jbc.M607490200 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.2.2 {ECO:0000269|PubMed:1360205, ECO:0000269|PubMed:16618936} http://www.genome.jp/dbget-bin/www_bget?EC:2.3.2.2 {ECO:0000269|PubMed:1360205, ECO:0000269|PubMed:16618936} EC_number EC:3.4.19.13 {ECO:0000250|UniProtKB:P54422} http://www.genome.jp/dbget-bin/www_bget?EC:3.4.19.13 {ECO:0000250|UniProtKB:P54422} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M28722 http://www.ebi.ac.uk/ena/data/view/M28722 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 2.3.2.2 {ECO:0000269|PubMed:1360205, ECO:0000269|PubMed:16618936} http://enzyme.expasy.org/EC/2.3.2.2 {ECO:0000269|PubMed:1360205, ECO:0000269|PubMed:16618936} ENZYME 3.4.19.13 {ECO:0000250|UniProtKB:P54422} http://enzyme.expasy.org/EC/3.4.19.13 {ECO:0000250|UniProtKB:P54422} EchoBASE EB0369 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0369 EcoGene EG10374 http://www.ecogene.org/geneInfo.php?eg_id=EG10374 EnsemblBacteria AAC76472 http://www.ensemblgenomes.org/id/AAC76472 EnsemblBacteria AAC76472 http://www.ensemblgenomes.org/id/AAC76472 EnsemblBacteria BAE77846 http://www.ensemblgenomes.org/id/BAE77846 EnsemblBacteria BAE77846 http://www.ensemblgenomes.org/id/BAE77846 EnsemblBacteria BAE77846 http://www.ensemblgenomes.org/id/BAE77846 EnsemblBacteria b3447 http://www.ensemblgenomes.org/id/b3447 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0003840 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003840 GO_function GO:0036374 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036374 GO_process GO:0006750 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006750 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 947947 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947947 HOGENOM HOG000175617 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000175617&db=HOGENOM6 InParanoid P18956 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P18956 IntAct P18956 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P18956* IntEnz 2.3.2.2 {ECO:0000269|PubMed:1360205, ECO:0000269|PubMed:16618936} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.2.2 {ECO:0000269|PubMed:1360205, ECO:0000269|PubMed:16618936} IntEnz 3.4.19.13 {ECO:0000250|UniProtKB:P54422} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.19.13 {ECO:0000250|UniProtKB:P54422} InterPro IPR000101 http://www.ebi.ac.uk/interpro/entry/IPR000101 InterPro IPR029055 http://www.ebi.ac.uk/interpro/entry/IPR029055 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Brite ko04090 http://www.genome.jp/dbget-bin/www_bget?ko04090 KEGG_Gene ecj:JW3412 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3412 KEGG_Gene eco:b3447 http://www.genome.jp/dbget-bin/www_bget?eco:b3447 KEGG_Orthology KO:K00681 http://www.genome.jp/dbget-bin/www_bget?KO:K00681 KEGG_Pathway ko00430 http://www.genome.jp/kegg-bin/show_pathway?ko00430 KEGG_Pathway ko00460 http://www.genome.jp/kegg-bin/show_pathway?ko00460 KEGG_Pathway ko00480 http://www.genome.jp/kegg-bin/show_pathway?ko00480 KEGG_Pathway ko00590 http://www.genome.jp/kegg-bin/show_pathway?ko00590 KEGG_Reaction rn:R00494 http://www.genome.jp/dbget-bin/www_bget?rn:R00494 KEGG_Reaction rn:R01262 http://www.genome.jp/dbget-bin/www_bget?rn:R01262 KEGG_Reaction rn:R01687 http://www.genome.jp/dbget-bin/www_bget?rn:R01687 KEGG_Reaction rn:R03867 http://www.genome.jp/dbget-bin/www_bget?rn:R03867 KEGG_Reaction rn:R03916 http://www.genome.jp/dbget-bin/www_bget?rn:R03916 KEGG_Reaction rn:R03970 http://www.genome.jp/dbget-bin/www_bget?rn:R03970 KEGG_Reaction rn:R03971 http://www.genome.jp/dbget-bin/www_bget?rn:R03971 KEGG_Reaction rn:R04935 http://www.genome.jp/dbget-bin/www_bget?rn:R04935 MINT MINT-1260227 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1260227 OMA STSHFVI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=STSHFVI PANTHER PTHR11686 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11686 PDB 2DBU http://www.ebi.ac.uk/pdbe-srv/view/entry/2DBU PDB 2DBW http://www.ebi.ac.uk/pdbe-srv/view/entry/2DBW PDB 2DBX http://www.ebi.ac.uk/pdbe-srv/view/entry/2DBX PDB 2DG5 http://www.ebi.ac.uk/pdbe-srv/view/entry/2DG5 PDB 2E0W http://www.ebi.ac.uk/pdbe-srv/view/entry/2E0W PDB 2E0X http://www.ebi.ac.uk/pdbe-srv/view/entry/2E0X PDB 2E0Y http://www.ebi.ac.uk/pdbe-srv/view/entry/2E0Y PDB 2Z8I http://www.ebi.ac.uk/pdbe-srv/view/entry/2Z8I PDB 2Z8J http://www.ebi.ac.uk/pdbe-srv/view/entry/2Z8J PDB 2Z8K http://www.ebi.ac.uk/pdbe-srv/view/entry/2Z8K PDB 5B5T http://www.ebi.ac.uk/pdbe-srv/view/entry/5B5T PDBsum 2DBU http://www.ebi.ac.uk/pdbsum/2DBU PDBsum 2DBW http://www.ebi.ac.uk/pdbsum/2DBW PDBsum 2DBX http://www.ebi.ac.uk/pdbsum/2DBX PDBsum 2DG5 http://www.ebi.ac.uk/pdbsum/2DG5 PDBsum 2E0W http://www.ebi.ac.uk/pdbsum/2E0W PDBsum 2E0X http://www.ebi.ac.uk/pdbsum/2E0X PDBsum 2E0Y http://www.ebi.ac.uk/pdbsum/2E0Y PDBsum 2Z8I http://www.ebi.ac.uk/pdbsum/2Z8I PDBsum 2Z8J http://www.ebi.ac.uk/pdbsum/2Z8J PDBsum 2Z8K http://www.ebi.ac.uk/pdbsum/2Z8K PDBsum 5B5T http://www.ebi.ac.uk/pdbsum/5B5T PRINTS PR01210 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01210 PROSITE PS00462 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00462 PSORT swissprot:GGT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GGT_ECOLI PSORT-B swissprot:GGT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GGT_ECOLI PSORT2 swissprot:GGT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GGT_ECOLI Pfam PF01019 http://pfam.xfam.org/family/PF01019 Phobius swissprot:GGT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GGT_ECOLI PhylomeDB P18956 http://phylomedb.org/?seqid=P18956 ProteinModelPortal P18956 http://www.proteinmodelportal.org/query/uniprot/P18956 PubMed 1360205 http://www.ncbi.nlm.nih.gov/pubmed/1360205 PubMed 16618936 http://www.ncbi.nlm.nih.gov/pubmed/16618936 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17135273 http://www.ncbi.nlm.nih.gov/pubmed/17135273 PubMed 18555071 http://www.ncbi.nlm.nih.gov/pubmed/18555071 PubMed 2570061 http://www.ncbi.nlm.nih.gov/pubmed/2570061 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417904 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417904 RefSeq WP_000595082 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000595082 SMR P18956 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P18956 STRING 511145.b3447 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3447&targetmode=cogs STRING COG0405 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0405&targetmode=cogs SUPFAM SSF56235 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56235 TIGRFAMs TIGR00066 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00066 UniProtKB GGT_ECOLI http://www.uniprot.org/uniprot/GGT_ECOLI UniProtKB-AC P18956 http://www.uniprot.org/uniprot/P18956 charge swissprot:GGT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GGT_ECOLI eggNOG COG0405 http://eggnogapi.embl.de/nog_data/html/tree/COG0405 eggNOG ENOG4105CFB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CFB epestfind swissprot:GGT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GGT_ECOLI garnier swissprot:GGT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GGT_ECOLI helixturnhelix swissprot:GGT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GGT_ECOLI hmoment swissprot:GGT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GGT_ECOLI iep swissprot:GGT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GGT_ECOLI inforesidue swissprot:GGT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GGT_ECOLI octanol swissprot:GGT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GGT_ECOLI pepcoil swissprot:GGT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GGT_ECOLI pepdigest swissprot:GGT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GGT_ECOLI pepinfo swissprot:GGT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GGT_ECOLI pepnet swissprot:GGT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GGT_ECOLI pepstats swissprot:GGT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GGT_ECOLI pepwheel swissprot:GGT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GGT_ECOLI pepwindow swissprot:GGT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GGT_ECOLI sigcleave swissprot:GGT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GGT_ECOLI ## Database ID URL or Descriptions # AltName EIIBC-MurNAc {ECO:0000303|PubMed 15060041} # AltName EIIBC-MurNAc {ECO:0000303|PubMed 15060041} # AltName PTS system N-acetylmuramic acid-specific EIIB component {ECO:0000303|PubMed 15060041} # AltName PTS system N-acetylmuramic acid-specific EIIB component {ECO:0000303|PubMed 15060041} # AltName PTS system N-acetylmuramic acid-specific EIIC component {ECO:0000303|PubMed 15060041} # BioGrid 4260573 11 # CATALYTIC ACTIVITY [Protein]-N(pi)-phospho-L-histidine + N- acetylmuramate(Side 1) = [protein]-L-histidine + N-acetylmuramate 6-phosphate(Side 2). {ECO:0000269|PubMed 15060041}. # CDD cd00212 PTS_IIB_glc # DOMAIN PTYBC_ECOLI The EIIB domain is phosphorylated by phospho-EIIA on a cysteinyl or histidyl residue, depending on the transported sugar. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the EIIC domain. {ECO 0000255|PROSITE-ProRule PRU00421}. # DOMAIN PTYBC_ECOLI The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site. {ECO 0000255|PROSITE-ProRule PRU00426}. # EcoGene EG14163 murP # FUNCTION PTYBC_ECOLI The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is responsible for growth on MurNAc as the sole source of carbon and energy. Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc), but cannot phosphorylate the carbon 6, probably because of the 1,6- anhydro ring. {ECO 0000269|PubMed 15060041, ECO 0000269|PubMed 16452451}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; ISM:EcoCyc. # GO_component GO:0016020 membrane; IDA:EcoCyc. # GO_function GO:0008982 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:InterPro. # GO_function GO:0016301 kinase activity; IEA:UniProtKB-KW. # GO_function GO:0090588 protein-phosphocysteine-N-acetylmuramate phosphotransferase system transporter activity; IMP:EcoCyc. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IMP:EcoCyc. # GO_process GO:0034219 carbohydrate transmembrane transport; IMP:EcoCyc. # GO_process GO:0043610 regulation of carbohydrate utilization; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # GOslim_process GO:0055085 transmembrane transport # Gene3D 3.30.1360.60 -; 1. # INDUCTION Induced by MurNAc 6-phosphate that releases the repressor MurR from the DNA. Also up-regulated by the cAMP receptor protein crp via the binding of crp-cAMP to a class I site upstream of the murQ promoter. Repressed by MurR in the absence of MurNAc 6-phosphate. {ECO:0000269|PubMed 18723630}. # InterPro IPR001996 PTS_IIB_1 # InterPro IPR003352 PTS_EIIC # InterPro IPR013013 PTS_EIIC_1 # InterPro IPR018113 PTrfase_EIIB_Cys # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00303 PTS system, N-acetylmuramic acid-specific II component # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko00520 Amino sugar and nucleotide sugar metabolism # KEGG_Pathway ko02060 Phosphotransferase system (PTS) # MISCELLANEOUS PTYBC_ECOLI The PTS domain EIIA required for activity was shown to be the crr-encoded enzyme IIA-glucose, EIIA-Glc. # Organism PTYBC_ECOLI Escherichia coli (strain K12) # PATRIC 32120243 VBIEscCol129921_2524 # PIR D65017 D65017 # PROSITE PS01035 PTS_EIIB_TYPE_1_CYS # PROSITE PS51098 PTS_EIIB_TYPE_1 # PROSITE PS51103 PTS_EIIC_TYPE_1 # Pfam PF00367 PTS_EIIB # Pfam PF02378 PTS_EIIC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName N-acetylmuramic acid permease IIC component {ECO:0000303|PubMed 15060041} # RecName N-acetylmuramic acid-specific phosphotransferase enzyme IIB component {ECO:0000303|PubMed 15060041} # RecName PTS system N-acetylmuramic acid-specific EIIBC component {ECO:0000303|PubMed 15060041} # RefSeq NP_416924 NC_000913.3 # RefSeq WP_001040483 NZ_CP014272.1 # SIMILARITY Contains 1 PTS EIIB type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00421}. # SIMILARITY Contains 1 PTS EIIC type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00426}. # SUBCELLULAR LOCATION PTYBC_ECOLI Cell inner membrane {ECO 0000255|PROSITE- ProRule PRU00426}; Multi-pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00426}. # SUPFAM SSF55604 SSF55604 # TCDB 4.A.1.2 the pts glucose-glucoside (glc) family # eggNOG COG2190 LUCA # eggNOG ENOG4105C5Y Bacteria BLAST swissprot:PTYBC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTYBC_ECOLI BioCyc ECOL316407:JW2422-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2422-MONOMER BioCyc EcoCyc:MONOMER0-5 http://biocyc.org/getid?id=EcoCyc:MONOMER0-5 BioCyc MetaCyc:MONOMER0-5 http://biocyc.org/getid?id=MetaCyc:MONOMER0-5 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00642-08 http://dx.doi.org/10.1128/JB.00642-08 DOI 10.1128/JB.186.8.2385-2392.2004 http://dx.doi.org/10.1128/JB.186.8.2385-2392.2004 DOI 10.1128/JB.188.4.1660-1662.2006 http://dx.doi.org/10.1128/JB.188.4.1660-1662.2006 EC_number EC:2.7.1.192 {ECO:0000269|PubMed:15060041} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.192 {ECO:0000269|PubMed:15060041} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.192 {ECO:0000269|PubMed:15060041} http://enzyme.expasy.org/EC/2.7.1.192 {ECO:0000269|PubMed:15060041} EchoBASE EB3915 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3915 EcoGene EG14163 http://www.ecogene.org/geneInfo.php?eg_id=EG14163 EnsemblBacteria AAC75482 http://www.ensemblgenomes.org/id/AAC75482 EnsemblBacteria AAC75482 http://www.ensemblgenomes.org/id/AAC75482 EnsemblBacteria BAA16313 http://www.ensemblgenomes.org/id/BAA16313 EnsemblBacteria BAA16313 http://www.ensemblgenomes.org/id/BAA16313 EnsemblBacteria BAA16313 http://www.ensemblgenomes.org/id/BAA16313 EnsemblBacteria b2429 http://www.ensemblgenomes.org/id/b2429 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0008982 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008982 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_function GO:0090588 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090588 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GO_process GO:0034219 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034219 GO_process GO:0043610 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043610 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 3.30.1360.60 http://www.cathdb.info/version/latest/superfamily/3.30.1360.60 GeneID 946894 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946894 HOGENOM HOG000102024 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000102024&db=HOGENOM6 InParanoid P77272 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77272 IntEnz 2.7.1.192 {ECO:0000269|PubMed:15060041} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.192 {ECO:0000269|PubMed:15060041} InterPro IPR001996 http://www.ebi.ac.uk/interpro/entry/IPR001996 InterPro IPR003352 http://www.ebi.ac.uk/interpro/entry/IPR003352 InterPro IPR013013 http://www.ebi.ac.uk/interpro/entry/IPR013013 InterPro IPR018113 http://www.ebi.ac.uk/interpro/entry/IPR018113 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2422 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2422 KEGG_Gene eco:b2429 http://www.genome.jp/dbget-bin/www_bget?eco:b2429 KEGG_Orthology KO:K11192 http://www.genome.jp/dbget-bin/www_bget?KO:K11192 KEGG_Pathway ko00520 http://www.genome.jp/kegg-bin/show_pathway?ko00520 KEGG_Pathway ko02060 http://www.genome.jp/kegg-bin/show_pathway?ko02060 KEGG_Reaction rn:R08559 http://www.genome.jp/dbget-bin/www_bget?rn:R08559 OMA GKVMLYL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GKVMLYL PROSITE PS01035 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01035 PROSITE PS51098 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51098 PROSITE PS51103 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51103 PSORT swissprot:PTYBC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTYBC_ECOLI PSORT-B swissprot:PTYBC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTYBC_ECOLI PSORT2 swissprot:PTYBC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTYBC_ECOLI Pfam PF00367 http://pfam.xfam.org/family/PF00367 Pfam PF02378 http://pfam.xfam.org/family/PF02378 Phobius swissprot:PTYBC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTYBC_ECOLI PhylomeDB P77272 http://phylomedb.org/?seqid=P77272 ProteinModelPortal P77272 http://www.proteinmodelportal.org/query/uniprot/P77272 PubMed 15060041 http://www.ncbi.nlm.nih.gov/pubmed/15060041 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16452451 http://www.ncbi.nlm.nih.gov/pubmed/16452451 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723630 http://www.ncbi.nlm.nih.gov/pubmed/18723630 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416924 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416924 RefSeq WP_001040483 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001040483 STRING 511145.b2429 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2429&targetmode=cogs SUPFAM SSF55604 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55604 TCDB 4.A.1.2 http://www.tcdb.org/search/result.php?tc=4.A.1.2 UniProtKB PTYBC_ECOLI http://www.uniprot.org/uniprot/PTYBC_ECOLI UniProtKB-AC P77272 http://www.uniprot.org/uniprot/P77272 charge swissprot:PTYBC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTYBC_ECOLI eggNOG COG2190 http://eggnogapi.embl.de/nog_data/html/tree/COG2190 eggNOG ENOG4105C5Y http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C5Y epestfind swissprot:PTYBC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTYBC_ECOLI garnier swissprot:PTYBC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTYBC_ECOLI helixturnhelix swissprot:PTYBC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTYBC_ECOLI hmoment swissprot:PTYBC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTYBC_ECOLI iep swissprot:PTYBC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTYBC_ECOLI inforesidue swissprot:PTYBC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTYBC_ECOLI octanol swissprot:PTYBC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTYBC_ECOLI pepcoil swissprot:PTYBC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTYBC_ECOLI pepdigest swissprot:PTYBC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTYBC_ECOLI pepinfo swissprot:PTYBC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTYBC_ECOLI pepnet swissprot:PTYBC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTYBC_ECOLI pepstats swissprot:PTYBC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTYBC_ECOLI pepwheel swissprot:PTYBC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTYBC_ECOLI pepwindow swissprot:PTYBC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTYBC_ECOLI sigcleave swissprot:PTYBC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTYBC_ECOLI ## Database ID URL or Descriptions # BioGrid 4260566 128 # EcoGene EG13160 yfeN # GO_component GO:0009279 cell outer membrane; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # InterPro IPR018013 Channel_Tsx-like # Organism YFEN_ECOLI Escherichia coli (strain K12) # PATRIC 32120197 VBIEscCol129921_2501 # PIR G65014 G65014 # Pfam PF03502 Channel_Tsx # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFEN_ECOLI Uncharacterized protein YfeN # RefSeq NP_416903 NC_000913.3 # RefSeq WP_000716421 NZ_LN832404.1 # SIMILARITY To V.parahaemolyticus OmpK. {ECO 0000305}. # SUPFAM SSF111364 SSF111364 # TCDB 1.B.10.3 the nucleoside-specific channel-forming outer membrane porin (tsx) family # eggNOG ENOG4108NFH Bacteria # eggNOG ENOG410Y3BS LUCA BLAST swissprot:YFEN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFEN_ECOLI BioCyc ECOL316407:JW2399-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2399-MONOMER BioCyc EcoCyc:G7256-MONOMER http://biocyc.org/getid?id=EcoCyc:G7256-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X73828 http://www.ebi.ac.uk/ena/data/view/X73828 EchoBASE EB2952 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2952 EcoGene EG13160 http://www.ecogene.org/geneInfo.php?eg_id=EG13160 EnsemblBacteria AAC75461 http://www.ensemblgenomes.org/id/AAC75461 EnsemblBacteria AAC75461 http://www.ensemblgenomes.org/id/AAC75461 EnsemblBacteria BAA16279 http://www.ensemblgenomes.org/id/BAA16279 EnsemblBacteria BAA16279 http://www.ensemblgenomes.org/id/BAA16279 EnsemblBacteria BAA16279 http://www.ensemblgenomes.org/id/BAA16279 EnsemblBacteria b2408 http://www.ensemblgenomes.org/id/b2408 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GeneID 946872 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946872 HOGENOM HOG000116701 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000116701&db=HOGENOM6 InterPro IPR018013 http://www.ebi.ac.uk/interpro/entry/IPR018013 KEGG_Gene ecj:JW2399 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2399 KEGG_Gene eco:b2408 http://www.genome.jp/dbget-bin/www_bget?eco:b2408 OMA WGELYGF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WGELYGF PSORT swissprot:YFEN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFEN_ECOLI PSORT-B swissprot:YFEN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFEN_ECOLI PSORT2 swissprot:YFEN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFEN_ECOLI Pfam PF03502 http://pfam.xfam.org/family/PF03502 Phobius swissprot:YFEN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFEN_ECOLI ProteinModelPortal P45564 http://www.proteinmodelportal.org/query/uniprot/P45564 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7559336 http://www.ncbi.nlm.nih.gov/pubmed/7559336 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416903 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416903 RefSeq WP_000716421 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000716421 STRING 511145.b2408 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2408&targetmode=cogs SUPFAM SSF111364 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF111364 TCDB 1.B.10.3 http://www.tcdb.org/search/result.php?tc=1.B.10.3 UniProtKB YFEN_ECOLI http://www.uniprot.org/uniprot/YFEN_ECOLI UniProtKB-AC P45564 http://www.uniprot.org/uniprot/P45564 charge swissprot:YFEN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFEN_ECOLI eggNOG ENOG4108NFH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108NFH eggNOG ENOG410Y3BS http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y3BS epestfind swissprot:YFEN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFEN_ECOLI garnier swissprot:YFEN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFEN_ECOLI helixturnhelix swissprot:YFEN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFEN_ECOLI hmoment swissprot:YFEN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFEN_ECOLI iep swissprot:YFEN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFEN_ECOLI inforesidue swissprot:YFEN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFEN_ECOLI octanol swissprot:YFEN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFEN_ECOLI pepcoil swissprot:YFEN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFEN_ECOLI pepdigest swissprot:YFEN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFEN_ECOLI pepinfo swissprot:YFEN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFEN_ECOLI pepnet swissprot:YFEN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFEN_ECOLI pepstats swissprot:YFEN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFEN_ECOLI pepwheel swissprot:YFEN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFEN_ECOLI pepwindow swissprot:YFEN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFEN_ECOLI sigcleave swissprot:YFEN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFEN_ECOLI ## Database ID URL or Descriptions # AltName Putative D-hexose-6-phosphate mutarotase {ECO:0000250|UniProtKB Q03161} # AltName YEAD_ECOLI Unknown protein from 2D-page spots T26/PR37 # BioGrid 4260309 22 # CATALYTIC ACTIVITY Alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate. {ECO:0000250|UniProtKB Q03161}. # CDD cd09020 D-hex-6-P-epi_like # EcoGene EG12679 yeaD # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0030246 carbohydrate binding; IEA:InterPro. # GO_function GO:0047938 glucose-6-phosphate 1-epimerase activity; IEA:UniProtKB-EC. # GO_process GO:0005975 carbohydrate metabolic process; IEA:InterPro. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006950 response to stress # Gene3D 2.70.98.10 -; 1. # IntAct P39173 2 # InterPro IPR008183 Aldose_1/G6P_1-epimerase # InterPro IPR011013 Gal_mutarotase_SF_dom # InterPro IPR014718 GH-type_carb-bd # InterPro IPR025532 G6P_1-epimerase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00010 Glycolysis / Gluconeogenesis # Organism YEAD_ECOLI Escherichia coli (strain K12) # PATRIC 32118871 VBIEscCol129921_1853 # PIR D64938 D64938 # PIRSF PIRSF016020 PHexose_mutarotase # Pfam PF01263 Aldose_epim # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Putative glucose-6-phosphate 1-epimerase {ECO:0000250|UniProtKB Q03161} # RefSeq NP_416294 NC_000913.3 # RefSeq WP_001335909 NZ_LN832404.1 # SIMILARITY Belongs to the glucose-6-phosphate 1-epimerase family. {ECO 0000305}. # SUBUNIT Monomer in solution. {ECO:0000269|PubMed 20693678}. # SUPFAM SSF74650 SSF74650 # eggNOG COG0676 LUCA # eggNOG ENOG4105DSB Bacteria BLAST swissprot:YEAD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEAD_ECOLI BioCyc ECOL316407:JW1769-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1769-MONOMER BioCyc EcoCyc:G6966-MONOMER http://biocyc.org/getid?id=EcoCyc:G6966-MONOMER COG COG0676 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0676 DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1107/S1744309110024140 http://dx.doi.org/10.1107/S1744309110024140 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.1.3.15 {ECO:0000250|UniProtKB:Q03161} http://www.genome.jp/dbget-bin/www_bget?EC:5.1.3.15 {ECO:0000250|UniProtKB:Q03161} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 5.1.3.15 {ECO:0000250|UniProtKB:Q03161} http://enzyme.expasy.org/EC/5.1.3.15 {ECO:0000250|UniProtKB:Q03161} EchoBASE EB2544 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2544 EcoGene EG12679 http://www.ecogene.org/geneInfo.php?eg_id=EG12679 EnsemblBacteria AAC74850 http://www.ensemblgenomes.org/id/AAC74850 EnsemblBacteria AAC74850 http://www.ensemblgenomes.org/id/AAC74850 EnsemblBacteria BAA15577 http://www.ensemblgenomes.org/id/BAA15577 EnsemblBacteria BAA15577 http://www.ensemblgenomes.org/id/BAA15577 EnsemblBacteria BAA15577 http://www.ensemblgenomes.org/id/BAA15577 EnsemblBacteria b1780 http://www.ensemblgenomes.org/id/b1780 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0030246 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030246 GO_function GO:0047938 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047938 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 2.70.98.10 http://www.cathdb.info/version/latest/superfamily/2.70.98.10 GeneID 946572 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946572 HOGENOM HOG000283048 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000283048&db=HOGENOM6 InParanoid P39173 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39173 IntAct P39173 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39173* IntEnz 5.1.3.15 {ECO:0000250|UniProtKB:Q03161} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.1.3.15 {ECO:0000250|UniProtKB:Q03161} InterPro IPR008183 http://www.ebi.ac.uk/interpro/entry/IPR008183 InterPro IPR011013 http://www.ebi.ac.uk/interpro/entry/IPR011013 InterPro IPR014718 http://www.ebi.ac.uk/interpro/entry/IPR014718 InterPro IPR025532 http://www.ebi.ac.uk/interpro/entry/IPR025532 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1769 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1769 KEGG_Gene eco:b1780 http://www.genome.jp/dbget-bin/www_bget?eco:b1780 KEGG_Orthology KO:K01792 http://www.genome.jp/dbget-bin/www_bget?KO:K01792 KEGG_Pathway ko00010 http://www.genome.jp/kegg-bin/show_pathway?ko00010 KEGG_Reaction rn:R02739 http://www.genome.jp/dbget-bin/www_bget?rn:R02739 OMA ICFPWFG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ICFPWFG PSORT swissprot:YEAD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEAD_ECOLI PSORT-B swissprot:YEAD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEAD_ECOLI PSORT2 swissprot:YEAD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEAD_ECOLI Pfam PF01263 http://pfam.xfam.org/family/PF01263 Phobius swissprot:YEAD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEAD_ECOLI PhylomeDB P39173 http://phylomedb.org/?seqid=P39173 ProteinModelPortal P39173 http://www.proteinmodelportal.org/query/uniprot/P39173 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20693678 http://www.ncbi.nlm.nih.gov/pubmed/20693678 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_416294 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416294 RefSeq WP_001335909 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001335909 SMR P39173 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39173 STRING 511145.b1780 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1780&targetmode=cogs STRING COG0676 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0676&targetmode=cogs SUPFAM SSF74650 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF74650 UniProtKB YEAD_ECOLI http://www.uniprot.org/uniprot/YEAD_ECOLI UniProtKB-AC P39173 http://www.uniprot.org/uniprot/P39173 charge swissprot:YEAD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEAD_ECOLI eggNOG COG0676 http://eggnogapi.embl.de/nog_data/html/tree/COG0676 eggNOG ENOG4105DSB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DSB epestfind swissprot:YEAD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEAD_ECOLI garnier swissprot:YEAD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEAD_ECOLI helixturnhelix swissprot:YEAD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEAD_ECOLI hmoment swissprot:YEAD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEAD_ECOLI iep swissprot:YEAD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEAD_ECOLI inforesidue swissprot:YEAD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEAD_ECOLI octanol swissprot:YEAD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEAD_ECOLI pepcoil swissprot:YEAD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEAD_ECOLI pepdigest swissprot:YEAD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEAD_ECOLI pepinfo swissprot:YEAD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEAD_ECOLI pepnet swissprot:YEAD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEAD_ECOLI pepstats swissprot:YEAD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEAD_ECOLI pepwheel swissprot:YEAD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEAD_ECOLI pepwindow swissprot:YEAD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEAD_ECOLI sigcleave swissprot:YEAD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEAD_ECOLI ## Database ID URL or Descriptions # BioGrid 4262989 12 # ESTHER ecoli-ycjy Dienelactone_hydrolase # EcoGene EG13922 ycjY # GO_process GO:0051301 cell division; IMP:EcoCyc. # GOslim_process GO:0051301 cell division # Gene3D 3.40.50.1820 -; 1. # IntAct P76049 2 # InterPro IPR022742 Hydrolase_4 # InterPro IPR029058 AB_hydrolase # Organism YCJY_ECOLI Escherichia coli (strain K12) # PATRIC 32117930 VBIEscCol129921_1385 # PIR B64882 B64882 # Pfam PF12146 Hydrolase_4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCJY_ECOLI Uncharacterized protein YcjY # RefSeq NP_415843 NC_000913.3 # RefSeq WP_001300523 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA14909.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SUPFAM SSF53474 SSF53474; 2 # eggNOG COG1073 LUCA # eggNOG ENOG4105ENX Bacteria BLAST swissprot:YCJY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCJY_ECOLI BioCyc ECOL316407:JW5804-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5804-MONOMER BioCyc EcoCyc:G6663-MONOMER http://biocyc.org/getid?id=EcoCyc:G6663-MONOMER COG COG1073 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1073 DIP DIP-11616N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11616N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3681 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3681 EcoGene EG13922 http://www.ecogene.org/geneInfo.php?eg_id=EG13922 EnsemblBacteria AAC74409 http://www.ensemblgenomes.org/id/AAC74409 EnsemblBacteria AAC74409 http://www.ensemblgenomes.org/id/AAC74409 EnsemblBacteria BAA14909 http://www.ensemblgenomes.org/id/BAA14909 EnsemblBacteria BAA14909 http://www.ensemblgenomes.org/id/BAA14909 EnsemblBacteria BAA14909 http://www.ensemblgenomes.org/id/BAA14909 EnsemblBacteria b1327 http://www.ensemblgenomes.org/id/b1327 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 Gene3D 3.40.50.1820 http://www.cathdb.info/version/latest/superfamily/3.40.50.1820 GeneID 945988 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945988 HOGENOM HOG000273854 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000273854&db=HOGENOM6 InParanoid P76049 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76049 IntAct P76049 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76049* InterPro IPR022742 http://www.ebi.ac.uk/interpro/entry/IPR022742 InterPro IPR029058 http://www.ebi.ac.uk/interpro/entry/IPR029058 KEGG_Gene ecj:JW5804 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5804 KEGG_Gene eco:b1327 http://www.genome.jp/dbget-bin/www_bget?eco:b1327 KEGG_Orthology KO:K06889 http://www.genome.jp/dbget-bin/www_bget?KO:K06889 PSORT swissprot:YCJY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCJY_ECOLI PSORT-B swissprot:YCJY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCJY_ECOLI PSORT2 swissprot:YCJY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCJY_ECOLI Pfam PF12146 http://pfam.xfam.org/family/PF12146 Phobius swissprot:YCJY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCJY_ECOLI PhylomeDB P76049 http://phylomedb.org/?seqid=P76049 ProteinModelPortal P76049 http://www.proteinmodelportal.org/query/uniprot/P76049 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415843 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415843 RefSeq WP_001300523 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300523 SMR P76049 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76049 STRING 511145.b1327 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1327&targetmode=cogs STRING COG1073 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1073&targetmode=cogs SUPFAM SSF53474 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53474 UniProtKB YCJY_ECOLI http://www.uniprot.org/uniprot/YCJY_ECOLI UniProtKB-AC P76049 http://www.uniprot.org/uniprot/P76049 charge swissprot:YCJY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCJY_ECOLI eggNOG COG1073 http://eggnogapi.embl.de/nog_data/html/tree/COG1073 eggNOG ENOG4105ENX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ENX epestfind swissprot:YCJY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCJY_ECOLI garnier swissprot:YCJY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCJY_ECOLI helixturnhelix swissprot:YCJY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCJY_ECOLI hmoment swissprot:YCJY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCJY_ECOLI iep swissprot:YCJY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCJY_ECOLI inforesidue swissprot:YCJY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCJY_ECOLI octanol swissprot:YCJY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCJY_ECOLI pepcoil swissprot:YCJY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCJY_ECOLI pepdigest swissprot:YCJY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCJY_ECOLI pepinfo swissprot:YCJY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCJY_ECOLI pepnet swissprot:YCJY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCJY_ECOLI pepstats swissprot:YCJY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCJY_ECOLI pepwheel swissprot:YCJY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCJY_ECOLI pepwindow swissprot:YCJY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCJY_ECOLI sigcleave swissprot:YCJY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCJY_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES Redox potential E(0) is -285 mV.; # BioGrid 4259601 9 # CDD cd01110 HTH_SoxR # EcoGene EG10957 soxR # FUNCTION SOXR_ECOLI Activates the transcription of the soxS gene which itself controls the superoxide response regulon. SoxR contains a 2Fe-2S iron-sulfur cluster that may act as a redox sensor system that recognizes superoxide. The variable redox state of the Fe-S cluster is employed in vivo to modulate the transcriptional activity of SoxR in response to specific types of oxidative stress. Upon reduction of 2Fe-2S cluster, SoxR reversibly loses its transcriptional activity, but retains its DNA binding affinity. # GO_component GO:0005737 cytoplasm; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051537 2 iron, 2 sulfur cluster binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006979 response to oxidative stress; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # IntAct P0ACS2 7 # InterPro IPR000551 MerR-type_HTH_dom # InterPro IPR009061 DNA-bd_dom_put # InterPro IPR010211 Redox-sen_tscrpt-act_SoxR # InterPro IPR015358 Tscrpt_reg_MerR_DNA-bd # KEGG_Brite ko03000 Transcription factors # Organism SOXR_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30204:SF0 PTHR30204:SF0 # PATRIC 32123671 VBIEscCol129921_4184 # PDB 2ZHG X-ray; 2.80 A; A=1-154 # PDB 2ZHH X-ray; 3.20 A; A=1-154 # PIR JS0577 JS0577 # PRINTS PR00040 HTHMERR # PROSITE PS00552 HTH_MERR_1 # PROSITE PS50937 HTH_MERR_2 # Pfam PF00376 MerR # Pfam PF09278 MerR-DNA-bind # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SOXR_ECOLI Redox-sensitive transcriptional activator SoxR # RefSeq NP_418487 NC_000913.3 # RefSeq WP_000412428 NZ_LN832404.1 # SIMILARITY Contains 1 HTH merR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00254}. # SMART SM00422 HTH_MERR # SUBUNIT SOXR_ECOLI Homodimer. # SUPFAM SSF46955 SSF46955 # TIGRFAMs TIGR01950 SoxR # eggNOG COG0789 LUCA # eggNOG ENOG4108Z4X Bacteria BLAST swissprot:SOXR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SOXR_ECOLI BioCyc ECOL316407:JW4024-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4024-MONOMER BioCyc EcoCyc:PD04132 http://biocyc.org/getid?id=EcoCyc:PD04132 COG COG0789 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0789 DIP DIP-29848N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-29848N DOI 10.1016/S0092-8674(00)81864-4 http://dx.doi.org/10.1016/S0092-8674(00)81864-4 DOI 10.1016/S0968-0004(97)01068-2 http://dx.doi.org/10.1016/S0968-0004(97)01068-2 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.270.36.20908 http://dx.doi.org/10.1074/jbc.270.36.20908 DOI 10.1074/jbc.271.13.7269 http://dx.doi.org/10.1074/jbc.271.13.7269 DOI 10.1074/jbc.271.52.33173 http://dx.doi.org/10.1074/jbc.271.52.33173 DOI 10.1093/nar/19.16.4479 http://dx.doi.org/10.1093/nar/19.16.4479 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1093/nar/22.15.2958 http://dx.doi.org/10.1093/nar/22.15.2958 DOI 10.1093/nar/25.8.1469 http://dx.doi.org/10.1093/nar/25.8.1469 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.185.8.2441-2450.2003 http://dx.doi.org/10.1128/JB.185.8.2441-2450.2003 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M60111 http://www.ebi.ac.uk/ena/data/view/M60111 EMBL S72675 http://www.ebi.ac.uk/ena/data/view/S72675 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X59593 http://www.ebi.ac.uk/ena/data/view/X59593 EchoBASE EB0950 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0950 EcoGene EG10957 http://www.ecogene.org/geneInfo.php?eg_id=EG10957 EnsemblBacteria AAC77033 http://www.ensemblgenomes.org/id/AAC77033 EnsemblBacteria AAC77033 http://www.ensemblgenomes.org/id/AAC77033 EnsemblBacteria BAE78065 http://www.ensemblgenomes.org/id/BAE78065 EnsemblBacteria BAE78065 http://www.ensemblgenomes.org/id/BAE78065 EnsemblBacteria BAE78065 http://www.ensemblgenomes.org/id/BAE78065 EnsemblBacteria b4063 http://www.ensemblgenomes.org/id/b4063 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051537 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051537 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0006979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 948566 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948566 HOGENOM HOG000266085 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000266085&db=HOGENOM6 InParanoid P0ACS2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACS2 IntAct P0ACS2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACS2* InterPro IPR000551 http://www.ebi.ac.uk/interpro/entry/IPR000551 InterPro IPR009061 http://www.ebi.ac.uk/interpro/entry/IPR009061 InterPro IPR010211 http://www.ebi.ac.uk/interpro/entry/IPR010211 InterPro IPR015358 http://www.ebi.ac.uk/interpro/entry/IPR015358 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW4024 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4024 KEGG_Gene eco:b4063 http://www.genome.jp/dbget-bin/www_bget?eco:b4063 KEGG_Orthology KO:K13639 http://www.genome.jp/dbget-bin/www_bget?KO:K13639 OMA NGNQRRY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NGNQRRY PANTHER PTHR30204:SF0 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30204:SF0 PDB 2ZHG http://www.ebi.ac.uk/pdbe-srv/view/entry/2ZHG PDB 2ZHH http://www.ebi.ac.uk/pdbe-srv/view/entry/2ZHH PDBsum 2ZHG http://www.ebi.ac.uk/pdbsum/2ZHG PDBsum 2ZHH http://www.ebi.ac.uk/pdbsum/2ZHH PRINTS PR00040 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00040 PROSITE PS00552 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00552 PROSITE PS50937 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50937 PSORT swissprot:SOXR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SOXR_ECOLI PSORT-B swissprot:SOXR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SOXR_ECOLI PSORT2 swissprot:SOXR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SOXR_ECOLI Pfam PF00376 http://pfam.xfam.org/family/PF00376 Pfam PF09278 http://pfam.xfam.org/family/PF09278 Phobius swissprot:SOXR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SOXR_ECOLI PhylomeDB P0ACS2 http://phylomedb.org/?seqid=P0ACS2 ProteinModelPortal P0ACS2 http://www.proteinmodelportal.org/query/uniprot/P0ACS2 PubMed 10207625 http://www.ncbi.nlm.nih.gov/pubmed/10207625 PubMed 12670967 http://www.ncbi.nlm.nih.gov/pubmed/12670967 PubMed 1653416 http://www.ncbi.nlm.nih.gov/pubmed/1653416 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1708380 http://www.ncbi.nlm.nih.gov/pubmed/1708380 PubMed 7673113 http://www.ncbi.nlm.nih.gov/pubmed/7673113 PubMed 8065907 http://www.ncbi.nlm.nih.gov/pubmed/8065907 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 8306957 http://www.ncbi.nlm.nih.gov/pubmed/8306957 PubMed 8631739 http://www.ncbi.nlm.nih.gov/pubmed/8631739 PubMed 8969171 http://www.ncbi.nlm.nih.gov/pubmed/8969171 PubMed 9019397 http://www.ncbi.nlm.nih.gov/pubmed/9019397 PubMed 9092651 http://www.ncbi.nlm.nih.gov/pubmed/9092651 PubMed 9204707 http://www.ncbi.nlm.nih.gov/pubmed/9204707 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418487 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418487 RefSeq WP_000412428 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000412428 SMART SM00422 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00422 SMR P0ACS2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACS2 STRING 511145.b4063 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4063&targetmode=cogs STRING COG0789 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0789&targetmode=cogs SUPFAM SSF46955 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46955 TIGRFAMs TIGR01950 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01950 UniProtKB SOXR_ECOLI http://www.uniprot.org/uniprot/SOXR_ECOLI UniProtKB-AC P0ACS2 http://www.uniprot.org/uniprot/P0ACS2 charge swissprot:SOXR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SOXR_ECOLI eggNOG COG0789 http://eggnogapi.embl.de/nog_data/html/tree/COG0789 eggNOG ENOG4108Z4X http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Z4X epestfind swissprot:SOXR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SOXR_ECOLI garnier swissprot:SOXR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SOXR_ECOLI helixturnhelix swissprot:SOXR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SOXR_ECOLI hmoment swissprot:SOXR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SOXR_ECOLI iep swissprot:SOXR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SOXR_ECOLI inforesidue swissprot:SOXR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SOXR_ECOLI octanol swissprot:SOXR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SOXR_ECOLI pepcoil swissprot:SOXR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SOXR_ECOLI pepdigest swissprot:SOXR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SOXR_ECOLI pepinfo swissprot:SOXR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SOXR_ECOLI pepnet swissprot:SOXR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SOXR_ECOLI pepstats swissprot:SOXR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SOXR_ECOLI pepwheel swissprot:SOXR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SOXR_ECOLI pepwindow swissprot:SOXR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SOXR_ECOLI sigcleave swissprot:SOXR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SOXR_ECOLI ## Database ID URL or Descriptions # BioGrid 4260661 6 # CDD cd07377 WHTH_GntR # EcoGene EG11088 pdhR # FUNCTION PDHR_ECOLI Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # Gene3D 1.20.120.530 -; 1. # IntAct P0ACL9 8 # InterPro IPR000524 Tscrpt_reg_HTH_GntR # InterPro IPR008920 TF_FadR/GntR_C # InterPro IPR011711 GntR_C # InterPro IPR011991 WHTH_DNA-bd_dom # KEGG_Brite ko03000 Transcription factors # Organism PDHR_ECOLI Escherichia coli (strain K12) # PATRIC 32115327 VBIEscCol129921_0115 # PIR A64734 BVECA # PRINTS PR00035 HTHGNTR # PROSITE PS50949 HTH_GNTR # Pfam PF00392 GntR # Pfam PF07729 FCD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PDHR_ECOLI Pyruvate dehydrogenase complex repressor # RefSeq NP_414655 NC_000913.3 # RefSeq WP_000331776 NZ_LN832404.1 # SIMILARITY Contains 1 HTH gntR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00307}. # SMART SM00345 HTH_GNTR # SMART SM00895 FCD # SUPFAM SSF46785 SSF46785 # SUPFAM SSF48008 SSF48008 # eggNOG COG2186 LUCA # eggNOG ENOG41073TP Bacteria BLAST swissprot:PDHR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PDHR_ECOLI BioCyc ECOL316407:JW0109-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0109-MONOMER BioCyc EcoCyc:EG11088-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11088-MONOMER COG COG2186 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2186 DOI 10.1016/0014-5793(93)81605-Y http://dx.doi.org/10.1016/0014-5793(93)81605-Y DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1432-1033.1983.tb07441.x http://dx.doi.org/10.1111/j.1432-1033.1983.tb07441.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL S67363 http://www.ebi.ac.uk/ena/data/view/S67363 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V01498 http://www.ebi.ac.uk/ena/data/view/V01498 EchoBASE EB1080 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1080 EcoGene EG11088 http://www.ecogene.org/geneInfo.php?eg_id=EG11088 EnsemblBacteria AAC73224 http://www.ensemblgenomes.org/id/AAC73224 EnsemblBacteria AAC73224 http://www.ensemblgenomes.org/id/AAC73224 EnsemblBacteria BAB96683 http://www.ensemblgenomes.org/id/BAB96683 EnsemblBacteria BAB96683 http://www.ensemblgenomes.org/id/BAB96683 EnsemblBacteria BAB96683 http://www.ensemblgenomes.org/id/BAB96683 EnsemblBacteria b0113 http://www.ensemblgenomes.org/id/b0113 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 1.20.120.530 http://www.cathdb.info/version/latest/superfamily/1.20.120.530 GeneID 944827 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944827 HOGENOM HOG000273991 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000273991&db=HOGENOM6 InParanoid P0ACL9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACL9 IntAct P0ACL9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACL9* InterPro IPR000524 http://www.ebi.ac.uk/interpro/entry/IPR000524 InterPro IPR008920 http://www.ebi.ac.uk/interpro/entry/IPR008920 InterPro IPR011711 http://www.ebi.ac.uk/interpro/entry/IPR011711 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW0109 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0109 KEGG_Gene eco:b0113 http://www.genome.jp/dbget-bin/www_bget?eco:b0113 KEGG_Orthology KO:K05799 http://www.genome.jp/dbget-bin/www_bget?KO:K05799 OMA NIGGMYK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NIGGMYK PRINTS PR00035 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00035 PROSITE PS50949 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50949 PSORT swissprot:PDHR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PDHR_ECOLI PSORT-B swissprot:PDHR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PDHR_ECOLI PSORT2 swissprot:PDHR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PDHR_ECOLI Pfam PF00392 http://pfam.xfam.org/family/PF00392 Pfam PF07729 http://pfam.xfam.org/family/PF07729 Phobius swissprot:PDHR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PDHR_ECOLI PhylomeDB P0ACL9 http://phylomedb.org/?seqid=P0ACL9 ProteinModelPortal P0ACL9 http://www.proteinmodelportal.org/query/uniprot/P0ACL9 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6343085 http://www.ncbi.nlm.nih.gov/pubmed/6343085 PubMed 8262214 http://www.ncbi.nlm.nih.gov/pubmed/8262214 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414655 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414655 RefSeq WP_000331776 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000331776 SMART SM00345 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00345 SMART SM00895 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00895 SMR P0ACL9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACL9 STRING 511145.b0113 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0113&targetmode=cogs STRING COG2186 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2186&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SUPFAM SSF48008 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48008 UniProtKB PDHR_ECOLI http://www.uniprot.org/uniprot/PDHR_ECOLI UniProtKB-AC P0ACL9 http://www.uniprot.org/uniprot/P0ACL9 charge swissprot:PDHR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PDHR_ECOLI eggNOG COG2186 http://eggnogapi.embl.de/nog_data/html/tree/COG2186 eggNOG ENOG41073TP http://eggnogapi.embl.de/nog_data/html/tree/ENOG41073TP epestfind swissprot:PDHR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PDHR_ECOLI garnier swissprot:PDHR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PDHR_ECOLI helixturnhelix swissprot:PDHR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PDHR_ECOLI hmoment swissprot:PDHR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PDHR_ECOLI iep swissprot:PDHR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PDHR_ECOLI inforesidue swissprot:PDHR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PDHR_ECOLI octanol swissprot:PDHR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PDHR_ECOLI pepcoil swissprot:PDHR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PDHR_ECOLI pepdigest swissprot:PDHR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PDHR_ECOLI pepinfo swissprot:PDHR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PDHR_ECOLI pepnet swissprot:PDHR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PDHR_ECOLI pepstats swissprot:PDHR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PDHR_ECOLI pepwheel swissprot:PDHR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PDHR_ECOLI pepwindow swissprot:PDHR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PDHR_ECOLI sigcleave swissprot:PDHR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PDHR_ECOLI ## Database ID URL or Descriptions # BioGrid 4260350 7 # EcoGene EG13277 torY # FUNCTION TORY_ECOLI Part of the anaerobic respiratory chain of trimethylamine-N-oxide reductase TorZ. Required for electron transfer to the TorZ terminal enzyme. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0009276 Gram-negative-bacterium-type cell wall; IEA:InterPro. # GO_function GO:0005506 iron ion binding; IEA:InterPro. # GO_function GO:0009055 electron carrier activity; IBA:GO_Central. # GO_function GO:0020037 heme binding; ISM:EcoCyc. # GO_process GO:0009061 anaerobic respiration; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005618 cell wall # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # InterPro IPR005126 NapC/NirT_cyt_c_N # InterPro IPR009154 Membr-bd_4haem_cyt_TorC # InterPro IPR011031 Multihaem_cyt # KEGG_Brite ko02000 Transporters # Organism TORY_ECOLI Escherichia coli (strain K12) # PATRIC 32119071 VBIEscCol129921_1953 # PIR A64950 A64950 # PIRSF PIRSF000014 4_hem_cytch_TorC # PROSITE PS51008 MULTIHEME_CYTC; 2 # PTM TORY_ECOLI Binds 5 heme groups per subunit. {ECO 0000250}. # Pfam PF03264 Cytochrom_NNT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TORY_ECOLI Cytochrome c-type protein TorY # RefSeq NP_416387 NC_000913.3 # RefSeq WP_001214331 NZ_LN832404.1 # SIMILARITY Belongs to the TorC/TorY family. {ECO 0000305}. # SUBCELLULAR LOCATION TORY_ECOLI Cell inner membrane {ECO 0000250}; Single- pass type II membrane protein {ECO 0000250}. # SUPFAM SSF48695 SSF48695 # TCDB 5.A.3.4 the prokaryotic molybdopterin-containing oxidoreductase (pmo) family # eggNOG COG3005 LUCA # eggNOG ENOG4105CUW Bacteria BLAST swissprot:TORY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TORY_ECOLI BioCyc ECOL316407:JW1862-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1862-MONOMER BioCyc EcoCyc:G7023-MONOMER http://biocyc.org/getid?id=EcoCyc:G7023-MONOMER BioCyc MetaCyc:G7023-MONOMER http://biocyc.org/getid?id=MetaCyc:G7023-MONOMER COG COG3005 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3005 DIP DIP-11829N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11829N DOI 10.1007/BF02198832 http://dx.doi.org/10.1007/BF02198832 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.20.5779-5786.2000 http://dx.doi.org/10.1128/JB.182.20.5779-5786.2000 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U38839 http://www.ebi.ac.uk/ena/data/view/U38839 EchoBASE EB3062 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3062 EcoGene EG13277 http://www.ecogene.org/geneInfo.php?eg_id=EG13277 EnsemblBacteria AAC74943 http://www.ensemblgenomes.org/id/AAC74943 EnsemblBacteria AAC74943 http://www.ensemblgenomes.org/id/AAC74943 EnsemblBacteria BAA15683 http://www.ensemblgenomes.org/id/BAA15683 EnsemblBacteria BAA15683 http://www.ensemblgenomes.org/id/BAA15683 EnsemblBacteria BAA15683 http://www.ensemblgenomes.org/id/BAA15683 EnsemblBacteria b1873 http://www.ensemblgenomes.org/id/b1873 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0009276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009276 GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0020037 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0020037 GO_process GO:0009061 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009061 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005618 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GeneID 946490 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946490 HOGENOM HOG000284378 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000284378&db=HOGENOM6 IntAct P52005 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P52005* InterPro IPR005126 http://www.ebi.ac.uk/interpro/entry/IPR005126 InterPro IPR009154 http://www.ebi.ac.uk/interpro/entry/IPR009154 InterPro IPR011031 http://www.ebi.ac.uk/interpro/entry/IPR011031 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1862 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1862 KEGG_Gene eco:b1873 http://www.genome.jp/dbget-bin/www_bget?eco:b1873 KEGG_Orthology KO:K07821 http://www.genome.jp/dbget-bin/www_bget?KO:K07821 OMA FNANQWI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FNANQWI PROSITE PS51008 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51008 PSORT swissprot:TORY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TORY_ECOLI PSORT-B swissprot:TORY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TORY_ECOLI PSORT2 swissprot:TORY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TORY_ECOLI Pfam PF03264 http://pfam.xfam.org/family/PF03264 Phobius swissprot:TORY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TORY_ECOLI ProteinModelPortal P52005 http://www.proteinmodelportal.org/query/uniprot/P52005 PubMed 11004177 http://www.ncbi.nlm.nih.gov/pubmed/11004177 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8919859 http://www.ncbi.nlm.nih.gov/pubmed/8919859 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416387 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416387 RefSeq WP_001214331 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001214331 STRING 511145.b1873 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1873&targetmode=cogs STRING COG3005 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3005&targetmode=cogs SUPFAM SSF48695 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48695 TCDB 5.A.3.4 http://www.tcdb.org/search/result.php?tc=5.A.3.4 UniProtKB TORY_ECOLI http://www.uniprot.org/uniprot/TORY_ECOLI UniProtKB-AC P52005 http://www.uniprot.org/uniprot/P52005 charge swissprot:TORY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TORY_ECOLI eggNOG COG3005 http://eggnogapi.embl.de/nog_data/html/tree/COG3005 eggNOG ENOG4105CUW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CUW epestfind swissprot:TORY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TORY_ECOLI garnier swissprot:TORY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TORY_ECOLI helixturnhelix swissprot:TORY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TORY_ECOLI hmoment swissprot:TORY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TORY_ECOLI iep swissprot:TORY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TORY_ECOLI inforesidue swissprot:TORY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TORY_ECOLI octanol swissprot:TORY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TORY_ECOLI pepcoil swissprot:TORY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TORY_ECOLI pepdigest swissprot:TORY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TORY_ECOLI pepinfo swissprot:TORY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TORY_ECOLI pepnet swissprot:TORY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TORY_ECOLI pepstats swissprot:TORY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TORY_ECOLI pepwheel swissprot:TORY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TORY_ECOLI pepwindow swissprot:TORY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TORY_ECOLI sigcleave swissprot:TORY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TORY_ECOLI ## Database ID URL or Descriptions # AltName LIVH_ECOLI LIV-I protein H # BioGrid 4262494 23 # EcoGene EG10538 livH # FUNCTION LIVH_ECOLI Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015658 branched-chain amino acid transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0015803 branched-chain amino acid transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR001851 ABC_transp_permease # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00237 Branched-chain amino acid transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism LIVH_ECOLI Escherichia coli (strain K12) # PATRIC 32122356 VBIEscCol129921_3555 # PIR S47676 QRECLH # Pfam PF02653 BPD_transp_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LIVH_ECOLI High-affinity branched-chain amino acid transport system permease protein LivH # RefSeq NP_417914 NC_000913.3 # RefSeq WP_001295111 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION LIVH_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 3.A.1.4 the atp-binding cassette (abc) superfamily # eggNOG COG0559 LUCA # eggNOG ENOG4105C32 Bacteria BLAST swissprot:LIVH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LIVH_ECOLI BioCyc ECOL316407:JW3422-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3422-MONOMER BioCyc EcoCyc:LIVH-MONOMER http://biocyc.org/getid?id=EcoCyc:LIVH-MONOMER BioCyc MetaCyc:LIVH-MONOMER http://biocyc.org/getid?id=MetaCyc:LIVH-MONOMER COG COG0559 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0559 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J05516 http://www.ebi.ac.uk/ena/data/view/J05516 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0533 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0533 EcoGene EG10538 http://www.ecogene.org/geneInfo.php?eg_id=EG10538 EnsemblBacteria AAC76482 http://www.ensemblgenomes.org/id/AAC76482 EnsemblBacteria AAC76482 http://www.ensemblgenomes.org/id/AAC76482 EnsemblBacteria BAE77836 http://www.ensemblgenomes.org/id/BAE77836 EnsemblBacteria BAE77836 http://www.ensemblgenomes.org/id/BAE77836 EnsemblBacteria BAE77836 http://www.ensemblgenomes.org/id/BAE77836 EnsemblBacteria b3457 http://www.ensemblgenomes.org/id/b3457 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015658 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015658 GO_process GO:0015803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015803 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 947965 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947965 HOGENOM HOG000202530 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000202530&db=HOGENOM6 InParanoid P0AEX7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEX7 InterPro IPR001851 http://www.ebi.ac.uk/interpro/entry/IPR001851 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3422 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3422 KEGG_Gene eco:b3457 http://www.genome.jp/dbget-bin/www_bget?eco:b3457 KEGG_Orthology KO:K01997 http://www.genome.jp/dbget-bin/www_bget?KO:K01997 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA LMYYGVA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LMYYGVA PSORT swissprot:LIVH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LIVH_ECOLI PSORT-B swissprot:LIVH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LIVH_ECOLI PSORT2 swissprot:LIVH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LIVH_ECOLI Pfam PF02653 http://pfam.xfam.org/family/PF02653 Phobius swissprot:LIVH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LIVH_ECOLI PhylomeDB P0AEX7 http://phylomedb.org/?seqid=P0AEX7 ProteinModelPortal P0AEX7 http://www.proteinmodelportal.org/query/uniprot/P0AEX7 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2195019 http://www.ncbi.nlm.nih.gov/pubmed/2195019 PubMed 3009409 http://www.ncbi.nlm.nih.gov/pubmed/3009409 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417914 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417914 RefSeq WP_001295111 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295111 STRING 511145.b3457 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3457&targetmode=cogs STRING COG0559 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0559&targetmode=cogs TCDB 3.A.1.4 http://www.tcdb.org/search/result.php?tc=3.A.1.4 UniProtKB LIVH_ECOLI http://www.uniprot.org/uniprot/LIVH_ECOLI UniProtKB-AC P0AEX7 http://www.uniprot.org/uniprot/P0AEX7 charge swissprot:LIVH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LIVH_ECOLI eggNOG COG0559 http://eggnogapi.embl.de/nog_data/html/tree/COG0559 eggNOG ENOG4105C32 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C32 epestfind swissprot:LIVH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LIVH_ECOLI garnier swissprot:LIVH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LIVH_ECOLI helixturnhelix swissprot:LIVH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LIVH_ECOLI hmoment swissprot:LIVH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LIVH_ECOLI iep swissprot:LIVH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LIVH_ECOLI inforesidue swissprot:LIVH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LIVH_ECOLI octanol swissprot:LIVH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LIVH_ECOLI pepcoil swissprot:LIVH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LIVH_ECOLI pepdigest swissprot:LIVH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LIVH_ECOLI pepinfo swissprot:LIVH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LIVH_ECOLI pepnet swissprot:LIVH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LIVH_ECOLI pepstats swissprot:LIVH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LIVH_ECOLI pepwheel swissprot:LIVH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LIVH_ECOLI pepwindow swissprot:LIVH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LIVH_ECOLI sigcleave swissprot:LIVH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LIVH_ECOLI ## Database ID URL or Descriptions # AltName LEP4_ECOLI Prepilin peptidase # AltName LEP4_ECOLI Prepilin peptidase # BioGrid 4262465 210 # CATALYTIC ACTIVITY LEP4_ECOLI Typically cleaves a -Gly-|-Phe- bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine. # EcoGene EG11359 gspO # FUNCTION LEP4_ECOLI Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue. {ECO 0000250}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0004190 aspartic-type endopeptidase activity; IEA:InterPro. # GO_function GO:0016740 transferase activity; IEA:UniProtKB-KW. # GO_process GO:0006810 transport; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008233 peptidase activity # GOslim_process GO:0006810 transport # INDUCTION Silenced by the DNA-binding protein H-NS under standard growth conditions. {ECO:0000269|PubMed 11118204}. # InterPro IPR000045 Prepilin_IV_endopep_pep # InterPro IPR014032 Peptidase_A24A_bac # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # KEGG_Brite ko02044 M00331 Type II general secretion system # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko03070 Bacterial secretion system # MISCELLANEOUS Part of a cryptic operon that encodes proteins involved in type II secretion machinery in other organisms, but is not expressed in strain K12. However, GspO is functional when expressed from a stronger promoter (PubMed:8655552). {ECO 0000305|PubMed:8655552}. # Organism LEP4_ECOLI Escherichia coli (strain K12) # PATRIC 32122102 VBIEscCol129921_3428 # PIR B65127 B65127 # PRINTS PR00864 PREPILNPTASE # Pfam PF01478 Peptidase_A24 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LEP4_ECOLI Leader peptidase # RecName LEP4_ECOLI N-methyltransferase # RecName LEP4_ECOLI Type 4 prepilin-like proteins leader peptide-processing enzyme # RecName LEP4_ECOLI Type 4 prepilin-like proteins leader peptide-processing enzyme # RefSeq NP_417794 NC_000913.3 # RefSeq WP_000178154 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase A24 family. {ECO 0000305}. # SUBCELLULAR LOCATION LEP4_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG COG1989 LUCA # eggNOG ENOG4105EHH Bacteria BLAST swissprot:LEP4_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LEP4_ECOLI BioCyc ECOL316407:JW3297-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3297-MONOMER BioCyc EcoCyc:EG11359-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11359-MONOMER BioCyc MetaCyc:EG11359-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11359-MONOMER COG COG1989 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1989 DOI 10.1016/0378-1119(91)90221-V http://dx.doi.org/10.1016/0378-1119(91)90221-V DOI 10.1016/0378-1119(94)90851-6 http://dx.doi.org/10.1016/0378-1119(94)90851-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/emboj/19.24.6697 http://dx.doi.org/10.1093/emboj/19.24.6697 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.- EC_number EC:3.4.23.43 http://www.genome.jp/dbget-bin/www_bget?EC:3.4.23.43 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L28106 http://www.ebi.ac.uk/ena/data/view/L28106 EMBL M27176 http://www.ebi.ac.uk/ena/data/view/M27176 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 2.1.1.- http://enzyme.expasy.org/EC/2.1.1.- ENZYME 3.4.23.43 http://enzyme.expasy.org/EC/3.4.23.43 EchoBASE EB1334 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1334 EcoGene EG11359 http://www.ecogene.org/geneInfo.php?eg_id=EG11359 EnsemblBacteria AAC76360 http://www.ensemblgenomes.org/id/AAC76360 EnsemblBacteria AAC76360 http://www.ensemblgenomes.org/id/AAC76360 EnsemblBacteria BAE77956 http://www.ensemblgenomes.org/id/BAE77956 EnsemblBacteria BAE77956 http://www.ensemblgenomes.org/id/BAE77956 EnsemblBacteria BAE77956 http://www.ensemblgenomes.org/id/BAE77956 EnsemblBacteria b3335 http://www.ensemblgenomes.org/id/b3335 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0004190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004190 GO_function GO:0016740 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016740 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 947840 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947840 HOGENOM HOG000248584 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000248584&db=HOGENOM6 InParanoid P25960 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P25960 IntEnz 2.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1 IntEnz 3.4.23.43 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.23.43 InterPro IPR000045 http://www.ebi.ac.uk/interpro/entry/IPR000045 InterPro IPR014032 http://www.ebi.ac.uk/interpro/entry/IPR014032 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW3297 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3297 KEGG_Gene eco:b3335 http://www.genome.jp/dbget-bin/www_bget?eco:b3335 KEGG_Orthology KO:K02464 http://www.genome.jp/dbget-bin/www_bget?KO:K02464 KEGG_Pathway ko03070 http://www.genome.jp/kegg-bin/show_pathway?ko03070 OMA NIMITMA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NIMITMA PRINTS PR00864 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00864 PSORT swissprot:LEP4_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LEP4_ECOLI PSORT-B swissprot:LEP4_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LEP4_ECOLI PSORT2 swissprot:LEP4_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LEP4_ECOLI Pfam PF01478 http://pfam.xfam.org/family/PF01478 Phobius swissprot:LEP4_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LEP4_ECOLI PhylomeDB P25960 http://phylomedb.org/?seqid=P25960 ProteinModelPortal P25960 http://www.proteinmodelportal.org/query/uniprot/P25960 PubMed 11118204 http://www.ncbi.nlm.nih.gov/pubmed/11118204 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1676385 http://www.ncbi.nlm.nih.gov/pubmed/1676385 PubMed 2661540 http://www.ncbi.nlm.nih.gov/pubmed/2661540 PubMed 7959070 http://www.ncbi.nlm.nih.gov/pubmed/7959070 PubMed 8655552 http://www.ncbi.nlm.nih.gov/pubmed/8655552 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417794 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417794 RefSeq WP_000178154 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000178154 STRING 511145.b3335 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3335&targetmode=cogs STRING COG1989 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1989&targetmode=cogs UniProtKB LEP4_ECOLI http://www.uniprot.org/uniprot/LEP4_ECOLI UniProtKB-AC P25960 http://www.uniprot.org/uniprot/P25960 charge swissprot:LEP4_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LEP4_ECOLI eggNOG COG1989 http://eggnogapi.embl.de/nog_data/html/tree/COG1989 eggNOG ENOG4105EHH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EHH epestfind swissprot:LEP4_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LEP4_ECOLI garnier swissprot:LEP4_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LEP4_ECOLI helixturnhelix swissprot:LEP4_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LEP4_ECOLI hmoment swissprot:LEP4_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LEP4_ECOLI iep swissprot:LEP4_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LEP4_ECOLI inforesidue swissprot:LEP4_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LEP4_ECOLI octanol swissprot:LEP4_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LEP4_ECOLI pepcoil swissprot:LEP4_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LEP4_ECOLI pepdigest swissprot:LEP4_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LEP4_ECOLI pepinfo swissprot:LEP4_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LEP4_ECOLI pepnet swissprot:LEP4_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LEP4_ECOLI pepstats swissprot:LEP4_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LEP4_ECOLI pepwheel swissprot:LEP4_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LEP4_ECOLI pepwindow swissprot:LEP4_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LEP4_ECOLI sigcleave swissprot:LEP4_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LEP4_ECOLI ## Database ID URL or Descriptions # BioGrid 4261339 150 # EcoGene EG11459 yifK # FUNCTION YIFK_ECOLI Probable amino-acid or metabolite transport protein. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0015179 L-amino acid transmembrane transporter activity; IBA:GO_Central. # GO_function GO:0015297 antiporter activity; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # InterPro IPR002293 AA/rel_permease1 # InterPro IPR004840 Amoino_acid_permease_CS # InterPro IPR004841 AA-permease/SLC12A_dom # Organism YIFK_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11785 PTHR11785 # PATRIC 32123087 VBIEscCol129921_3913 # PIR H65183 H65183 # PIRSF PIRSF006060 AA_transporter # PROSITE PS00218 AMINO_ACID_PERMEASE_1 # Pfam PF00324 AA_permease # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIFK_ECOLI Probable transport protein YifK # RefSeq WP_000774731 NZ_LN832404.1 # RefSeq YP_026258 NC_000913.3 # SIMILARITY Belongs to the amino acid-polyamine-organocation (APC) superfamily. {ECO 0000305}. # SUBCELLULAR LOCATION YIFK_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.3.1.15 the amino acid-polyamine-organocation (apc) family # eggNOG COG1113 LUCA # eggNOG ENOG4105C85 Bacteria BLAST swissprot:YIFK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIFK_ECOLI BioCyc ECOL316407:JW5595-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5595-MONOMER BioCyc EcoCyc:YIFK-MONOMER http://biocyc.org/getid?id=EcoCyc:YIFK-MONOMER COG COG0833 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0833 COG COG1113 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1113 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1428 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1428 EcoGene EG11459 http://www.ecogene.org/geneInfo.php?eg_id=EG11459 EnsemblBacteria AAT48216 http://www.ensemblgenomes.org/id/AAT48216 EnsemblBacteria AAT48216 http://www.ensemblgenomes.org/id/AAT48216 EnsemblBacteria BAE77502 http://www.ensemblgenomes.org/id/BAE77502 EnsemblBacteria BAE77502 http://www.ensemblgenomes.org/id/BAE77502 EnsemblBacteria BAE77502 http://www.ensemblgenomes.org/id/BAE77502 EnsemblBacteria b3795 http://www.ensemblgenomes.org/id/b3795 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015179 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015179 GO_function GO:0015297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015297 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GeneID 945400 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945400 HOGENOM HOG000261849 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261849&db=HOGENOM6 InParanoid P27837 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P27837 InterPro IPR002293 http://www.ebi.ac.uk/interpro/entry/IPR002293 InterPro IPR004840 http://www.ebi.ac.uk/interpro/entry/IPR004840 InterPro IPR004841 http://www.ebi.ac.uk/interpro/entry/IPR004841 KEGG_Gene ecj:JW5595 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5595 KEGG_Gene eco:b3795 http://www.genome.jp/dbget-bin/www_bget?eco:b3795 KEGG_Orthology KO:K03293 http://www.genome.jp/dbget-bin/www_bget?KO:K03293 OMA ETRMSLF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ETRMSLF PANTHER PTHR11785 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11785 PROSITE PS00218 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00218 PSORT swissprot:YIFK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIFK_ECOLI PSORT-B swissprot:YIFK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIFK_ECOLI PSORT2 swissprot:YIFK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIFK_ECOLI Pfam PF00324 http://pfam.xfam.org/family/PF00324 Phobius swissprot:YIFK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIFK_ECOLI PhylomeDB P27837 http://phylomedb.org/?seqid=P27837 ProteinModelPortal P27837 http://www.proteinmodelportal.org/query/uniprot/P27837 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000774731 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000774731 RefSeq YP_026258 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026258 STRING 511145.b3795 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3795&targetmode=cogs STRING COG0833 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0833&targetmode=cogs STRING COG1113 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1113&targetmode=cogs TCDB 2.A.3.1.15 http://www.tcdb.org/search/result.php?tc=2.A.3.1.15 UniProtKB YIFK_ECOLI http://www.uniprot.org/uniprot/YIFK_ECOLI UniProtKB-AC P27837 http://www.uniprot.org/uniprot/P27837 charge swissprot:YIFK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIFK_ECOLI eggNOG COG1113 http://eggnogapi.embl.de/nog_data/html/tree/COG1113 eggNOG ENOG4105C85 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C85 epestfind swissprot:YIFK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIFK_ECOLI garnier swissprot:YIFK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIFK_ECOLI helixturnhelix swissprot:YIFK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIFK_ECOLI hmoment swissprot:YIFK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIFK_ECOLI iep swissprot:YIFK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIFK_ECOLI inforesidue swissprot:YIFK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIFK_ECOLI octanol swissprot:YIFK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIFK_ECOLI pepcoil swissprot:YIFK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIFK_ECOLI pepdigest swissprot:YIFK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIFK_ECOLI pepinfo swissprot:YIFK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIFK_ECOLI pepnet swissprot:YIFK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIFK_ECOLI pepstats swissprot:YIFK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIFK_ECOLI pepwheel swissprot:YIFK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIFK_ECOLI pepwindow swissprot:YIFK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIFK_ECOLI sigcleave swissprot:YIFK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIFK_ECOLI ## Database ID URL or Descriptions # CDD cd01658 Ribosomal_L30 # EcoGene EG10888 rpmD # GO_component GO:0022625 cytosolic large ribosomal subunit; IDA:EcoCyc. # GO_function GO:0003735 structural constituent of ribosome; IEA:InterPro. # GO_process GO:0006412 translation; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_process GO:0006412 translation # Gene3D 3.30.1390.20 -; 1. # HAMAP MF_01371_B Ribosomal_L30_B # IntAct P0AG51 3 # InterPro IPR005996 Ribosomal_L30_bac-type # InterPro IPR016082 Ribosomal_L30_ferredoxin-like # InterPro IPR018038 Ribosomal_L30_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 M00179 Ribosome, archaea # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=6410.3; Method=MALDI; Range=2-59; Evidence={ECO:0000269|PubMed 10094780}; # MISCELLANEOUS RL30_ECOLI This protein is located near the guanosine triphosphatase center of the 50S subunit. # Organism RL30_ECOLI Escherichia coli (strain K12) # PATRIC 32122036 VBIEscCol129921_3395 # PDB 1ML5 EM; 14.00 A; x=1-59 # PDB 2J28 EM; 8.00 A; Y=2-59 # PDB 2RDO EM; 9.10 A; Y=2-59 # PDB 3BBX EM; 10.00 A; Y=2-59 # PDB 3J5L EM; 6.60 A; Z=2-59 # PDB 3J7Z EM; 3.90 A; Z=1-59 # PDB 3J8G EM; 5.00 A; 2=1-59 # PDB 3J9Y EM; 3.90 A; Z=1-59 # PDB 3J9Z EM; 3.60 A; LY=2-59 # PDB 3JA1 EM; 3.60 A; L1=2-59 # PDB 3JBU EM; 3.64 A; 2=1-59 # PDB 3JBV EM; 3.32 A; 2=1-59 # PDB 3JCD EM; 3.70 A; Z=1-59 # PDB 3JCE EM; 3.20 A; Z=1-59 # PDB 3JCJ EM; 3.70 A; Y=1-59 # PDB 3JCN EM; 4.60 A; Z=1-59 # PDB 4CSU EM; 5.50 A; 2=2-59 # PDB 4U1U X-ray; 2.95 A; BZ/DZ=2-59 # PDB 4U1V X-ray; 3.00 A; BZ/DZ=2-59 # PDB 4U20 X-ray; 2.90 A; BZ/DZ=2-59 # PDB 4U24 X-ray; 2.90 A; BZ/DZ=2-59 # PDB 4U25 X-ray; 2.90 A; BZ/DZ=2-59 # PDB 4U26 X-ray; 2.80 A; BZ/DZ=2-59 # PDB 4U27 X-ray; 2.80 A; BZ/DZ=2-59 # PDB 4UY8 EM; 3.80 A; Z=2-59 # PDB 4V47 EM; 12.30 A; AX=2-59 # PDB 4V48 EM; 11.50 A; AX=2-59 # PDB 4V4H X-ray; 3.46 A; BY/DY=1-59 # PDB 4V4Q X-ray; 3.46 A; BY/DY=2-59 # PDB 4V4V EM; 15.00 A; BX=4-59 # PDB 4V4W EM; 15.00 A; BX=4-59 # PDB 4V50 X-ray; 3.22 A; BZ/DZ=2-59 # PDB 4V52 X-ray; 3.21 A; BY/DY=2-59 # PDB 4V53 X-ray; 3.54 A; BY/DY=2-59 # PDB 4V54 X-ray; 3.30 A; BY/DY=2-59 # PDB 4V55 X-ray; 4.00 A; BY/DY=2-59 # PDB 4V56 X-ray; 3.93 A; BY/DY=2-59 # PDB 4V57 X-ray; 3.50 A; BY/DY=2-59 # PDB 4V5B X-ray; 3.74 A; AY/CY=2-59 # PDB 4V5H EM; 5.80 A; B2=2-59 # PDB 4V5Y X-ray; 4.45 A; BY/DY=2-59 # PDB 4V64 X-ray; 3.50 A; BY/DY=2-59 # PDB 4V65 EM; 9.00 A; BR=1-59 # PDB 4V66 EM; 9.00 A; BR=1-59 # PDB 4V69 EM; 6.70 A; BZ=2-59 # PDB 4V6C X-ray; 3.19 A; BZ/DZ=1-59 # PDB 4V6D X-ray; 3.81 A; BZ/DZ=1-59 # PDB 4V6E X-ray; 3.71 A; BZ/DZ=1-59 # PDB 4V6K EM; 8.25 A; Aa=1-59 # PDB 4V6L EM; 13.20 A; Ba=1-59 # PDB 4V6M EM; 7.10 A; BZ=2-59 # PDB 4V6N EM; 12.10 A; A1=2-59 # PDB 4V6O EM; 14.70 A; B1=2-59 # PDB 4V6P EM; 13.50 A; B1=2-59 # PDB 4V6Q EM; 11.50 A; B1=2-59 # PDB 4V6R EM; 11.50 A; B1=2-59 # PDB 4V6S EM; 13.10 A; A1=2-59 # PDB 4V6T EM; 8.30 A; BZ=2-59 # PDB 4V6V EM; 9.80 A; B3=2-59 # PDB 4V6Y EM; 12.00 A; BZ=1-59 # PDB 4V6Z EM; 12.00 A; BZ=1-59 # PDB 4V70 EM; 17.00 A; BZ=1-59 # PDB 4V71 EM; 20.00 A; BZ=1-59 # PDB 4V72 EM; 13.00 A; BZ=1-59 # PDB 4V73 EM; 15.00 A; BZ=1-59 # PDB 4V74 EM; 17.00 A; BZ=1-59 # PDB 4V75 EM; 12.00 A; BZ=1-59 # PDB 4V76 EM; 17.00 A; BZ=1-59 # PDB 4V77 EM; 17.00 A; BZ=1-59 # PDB 4V78 EM; 20.00 A; BZ=1-59 # PDB 4V79 EM; 15.00 A; BZ=1-59 # PDB 4V7A EM; 9.00 A; BZ=1-59 # PDB 4V7B EM; 6.80 A; BZ=1-59 # PDB 4V7C EM; 7.60 A; B2=2-59 # PDB 4V7D EM; 7.60 A; A3=2-59 # PDB 4V7I EM; 9.60 A; AZ=1-59 # PDB 4V7S X-ray; 3.25 A; BZ/DZ=2-59 # PDB 4V7T X-ray; 3.19 A; BZ/DZ=2-59 # PDB 4V7U X-ray; 3.10 A; BZ/DZ=2-59 # PDB 4V7V X-ray; 3.29 A; BZ/DZ=2-59 # PDB 4V85 X-ray; 3.20 A; 3=1-59 # PDB 4V89 X-ray; 3.70 A; B3=1-59 # PDB 4V9C X-ray; 3.30 A; BZ/DZ=1-59 # PDB 4V9D X-ray; 3.00 A; CZ/DZ=2-59 # PDB 4V9O X-ray; 2.90 A; AZ/CZ/EZ/GZ=1-59 # PDB 4V9P X-ray; 2.90 A; AZ/CZ/EZ/GZ=1-59 # PDB 4WF1 X-ray; 3.09 A; BZ/DZ=2-59 # PDB 4WOI X-ray; 3.00 A; BZ/CZ=1-59 # PDB 4WWW X-ray; 3.10 A; RZ/YZ=2-59 # PDB 4YBB X-ray; 2.10 A; C0/D0=2-59 # PDB 5ADY EM; 4.50 A; Z=1-59 # PDB 5AFI EM; 2.90 A; Z=1-59 # PDB 5AKA EM; 5.70 A; Y=2-59 # PDB 5GAD EM; 3.70 A; a=1-59 # PDB 5GAE EM; 3.33 A; a=1-59 # PDB 5GAF EM; 4.30 A; a=2-59 # PDB 5GAG EM; 3.80 A; a=1-59 # PDB 5GAH EM; 3.80 A; a=1-59 # PDB 5IQR EM; 3.00 A; Z=1-59 # PDB 5IT8 X-ray; 3.12 A; C0/D0=2-59 # PDB 5J5B X-ray; 2.80 A; C0/D0=2-59 # PDB 5J7L X-ray; 3.00 A; C0/D0=2-59 # PDB 5J88 X-ray; 3.32 A; C0/D0=2-59 # PDB 5J8A X-ray; 3.10 A; C0/D0=2-59 # PDB 5J91 X-ray; 2.96 A; C0/D0=2-59 # PDB 5JC9 X-ray; 3.03 A; C0/D0=2-59 # PDB 5JTE EM; 3.60 A; BZ=1-59 # PDB 5JU8 EM; 3.60 A; BZ=1-59 # PDB 5KCR EM; 3.60 A; 13=1-59 # PDB 5KCS EM; 3.90 A; 13=1-59 # PDB 5KPS EM; 3.90 A; Z=1-59 # PDB 5KPV EM; 4.10 A; Y=1-59 # PDB 5KPW EM; 3.90 A; Y=1-59 # PDB 5KPX EM; 3.90 A; Y=1-59 # PDB 5L3P EM; 3.70 A; 3=1-59 # PIR A65123 R5EC30 # PIRSF PIRSF002211 Ribosomal_L30_bac-type # PROSITE PS00634 RIBOSOMAL_L30 # Pfam PF00327 Ribosomal_L30 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 50S ribosomal protein L30 {ECO:0000255|HAMAP-Rule MF_01371} # RefSeq NP_417761 NC_000913.3 # RefSeq WP_001140433 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein L30P family. {ECO:0000255|HAMAP-Rule MF_01371}. # SUBUNIT RL30_ECOLI Part of the 50S ribosomal subunit. # SUPFAM SSF55129 SSF55129 # TIGRFAMs TIGR01308 rpmD_bact # eggNOG COG1841 LUCA # eggNOG ENOG4105VPB Bacteria BLAST swissprot:RL30_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RL30_ECOLI BioCyc ECOL316407:JW3264-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3264-MONOMER BioCyc EcoCyc:EG10888-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10888-MONOMER BioCyc MetaCyc:EG10888-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10888-MONOMER COG COG1841 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1841 DIP DIP-35970N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35970N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1016/0014-5793(75)80440-6 http://dx.doi.org/10.1016/0014-5793(75)80440-6 DOI 10.1016/S0092-8674(03)00427-6 http://dx.doi.org/10.1016/S0092-8674(03)00427-6 DOI 10.1016/j.celrep.2014.09.011 http://dx.doi.org/10.1016/j.celrep.2014.09.011 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/11.9.2599 http://dx.doi.org/10.1093/nar/11.9.2599 DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pbio.1001866 http://dx.doi.org/10.1371/journal.pbio.1001866 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X01563 http://www.ebi.ac.uk/ena/data/view/X01563 EchoBASE EB0881 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0881 EcoGene EG10888 http://www.ecogene.org/geneInfo.php?eg_id=EG10888 EnsemblBacteria AAC76327 http://www.ensemblgenomes.org/id/AAC76327 EnsemblBacteria AAC76327 http://www.ensemblgenomes.org/id/AAC76327 EnsemblBacteria BAE77989 http://www.ensemblgenomes.org/id/BAE77989 EnsemblBacteria BAE77989 http://www.ensemblgenomes.org/id/BAE77989 EnsemblBacteria BAE77989 http://www.ensemblgenomes.org/id/BAE77989 EnsemblBacteria b3302 http://www.ensemblgenomes.org/id/b3302 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0022625 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022625 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 Gene3D 3.30.1390.20 http://www.cathdb.info/version/latest/superfamily/3.30.1390.20 GeneID 947797 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947797 HAMAP MF_01371_B http://hamap.expasy.org/unirule/MF_01371_B HOGENOM HOG000039916 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000039916&db=HOGENOM6 InParanoid P0AG51 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AG51 IntAct P0AG51 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AG51* InterPro IPR005996 http://www.ebi.ac.uk/interpro/entry/IPR005996 InterPro IPR016082 http://www.ebi.ac.uk/interpro/entry/IPR016082 InterPro IPR018038 http://www.ebi.ac.uk/interpro/entry/IPR018038 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW3264 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3264 KEGG_Gene eco:b3302 http://www.genome.jp/dbget-bin/www_bget?eco:b3302 KEGG_Orthology KO:K02907 http://www.genome.jp/dbget-bin/www_bget?KO:K02907 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 OMA IRTVAHL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IRTVAHL PDB 1ML5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ML5 PDB 2J28 http://www.ebi.ac.uk/pdbe-srv/view/entry/2J28 PDB 2RDO http://www.ebi.ac.uk/pdbe-srv/view/entry/2RDO PDB 3BBX http://www.ebi.ac.uk/pdbe-srv/view/entry/3BBX PDB 3J5L http://www.ebi.ac.uk/pdbe-srv/view/entry/3J5L PDB 3J7Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J7Z PDB 3J8G http://www.ebi.ac.uk/pdbe-srv/view/entry/3J8G PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 4CSU http://www.ebi.ac.uk/pdbe-srv/view/entry/4CSU PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4UY8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4UY8 PDB 4V47 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V47 PDB 4V48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V48 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5ADY http://www.ebi.ac.uk/pdbe-srv/view/entry/5ADY PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5AKA http://www.ebi.ac.uk/pdbe-srv/view/entry/5AKA PDB 5GAD http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAD PDB 5GAE http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAE PDB 5GAF http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAF PDB 5GAG http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAG PDB 5GAH http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAH PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 1ML5 http://www.ebi.ac.uk/pdbsum/1ML5 PDBsum 2J28 http://www.ebi.ac.uk/pdbsum/2J28 PDBsum 2RDO http://www.ebi.ac.uk/pdbsum/2RDO PDBsum 3BBX http://www.ebi.ac.uk/pdbsum/3BBX PDBsum 3J5L http://www.ebi.ac.uk/pdbsum/3J5L PDBsum 3J7Z http://www.ebi.ac.uk/pdbsum/3J7Z PDBsum 3J8G http://www.ebi.ac.uk/pdbsum/3J8G PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 4CSU http://www.ebi.ac.uk/pdbsum/4CSU PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4UY8 http://www.ebi.ac.uk/pdbsum/4UY8 PDBsum 4V47 http://www.ebi.ac.uk/pdbsum/4V47 PDBsum 4V48 http://www.ebi.ac.uk/pdbsum/4V48 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5ADY http://www.ebi.ac.uk/pdbsum/5ADY PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5AKA http://www.ebi.ac.uk/pdbsum/5AKA PDBsum 5GAD http://www.ebi.ac.uk/pdbsum/5GAD PDBsum 5GAE http://www.ebi.ac.uk/pdbsum/5GAE PDBsum 5GAF http://www.ebi.ac.uk/pdbsum/5GAF PDBsum 5GAG http://www.ebi.ac.uk/pdbsum/5GAG PDBsum 5GAH http://www.ebi.ac.uk/pdbsum/5GAH PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PROSITE PS00634 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00634 PSORT swissprot:RL30_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RL30_ECOLI PSORT-B swissprot:RL30_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RL30_ECOLI PSORT2 swissprot:RL30_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RL30_ECOLI Pfam PF00327 http://pfam.xfam.org/family/PF00327 Phobius swissprot:RL30_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RL30_ECOLI PhylomeDB P0AG51 http://phylomedb.org/?seqid=P0AG51 ProteinModelPortal P0AG51 http://www.proteinmodelportal.org/query/uniprot/P0AG51 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 12809609 http://www.ncbi.nlm.nih.gov/pubmed/12809609 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 24844575 http://www.ncbi.nlm.nih.gov/pubmed/24844575 PubMed 25310980 http://www.ncbi.nlm.nih.gov/pubmed/25310980 PubMed 6222285 http://www.ncbi.nlm.nih.gov/pubmed/6222285 PubMed 776670 http://www.ncbi.nlm.nih.gov/pubmed/776670 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417761 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417761 RefSeq WP_001140433 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001140433 SMR P0AG51 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AG51 STRING 511145.b3302 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3302&targetmode=cogs STRING COG1841 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1841&targetmode=cogs SUPFAM SSF55129 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55129 TIGRFAMs TIGR01308 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01308 UniProtKB RL30_ECOLI http://www.uniprot.org/uniprot/RL30_ECOLI UniProtKB-AC P0AG51 http://www.uniprot.org/uniprot/P0AG51 charge swissprot:RL30_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RL30_ECOLI eggNOG COG1841 http://eggnogapi.embl.de/nog_data/html/tree/COG1841 eggNOG ENOG4105VPB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VPB epestfind swissprot:RL30_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RL30_ECOLI garnier swissprot:RL30_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RL30_ECOLI helixturnhelix swissprot:RL30_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RL30_ECOLI hmoment swissprot:RL30_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RL30_ECOLI iep swissprot:RL30_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RL30_ECOLI inforesidue swissprot:RL30_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RL30_ECOLI octanol swissprot:RL30_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RL30_ECOLI pepcoil swissprot:RL30_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RL30_ECOLI pepdigest swissprot:RL30_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RL30_ECOLI pepinfo swissprot:RL30_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RL30_ECOLI pepnet swissprot:RL30_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RL30_ECOLI pepstats swissprot:RL30_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RL30_ECOLI pepwheel swissprot:RL30_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RL30_ECOLI pepwindow swissprot:RL30_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RL30_ECOLI sigcleave swissprot:RL30_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RL30_ECOLI ## Database ID URL or Descriptions # BioGrid 4261413 243 # EcoGene EG10272 exbD # FUNCTION EXBD_ECOLI Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005215 transporter activity; IEA:InterPro. # GO_function GO:0031992 energy transducer activity; IMP:EcoCyc. # GO_process GO:0015031 protein transport; IEA:UniProtKB-KW. # GO_process GO:0043213 bacteriocin transport; IEA:UniProtKB-KW. # GO_process GO:0050821 protein stabilization; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # INDUCTION Induced 2.1-fold by hydroxyurea. {ECO:0000269|PubMed 20005847}. # INTERACTION EXBD_ECOLI Self; NbExp=3; IntAct=EBI-6417016, EBI-6417016; P0ABU7 exbB; NbExp=2; IntAct=EBI-6417016, EBI-6399986; P02929 tonB; NbExp=3; IntAct=EBI-6417016, EBI-6399993; # IntAct P0ABV2 4 # InterPro IPR003400 ExbD # InterPro IPR014170 TonB_ExbD_1 # KEGG_Brite ko02000 Transporters # Organism EXBD_ECOLI Escherichia coli (strain K12) # PATRIC 32121426 VBIEscCol129921_3100 # PDB 2PFU NMR; -; A=44-141 # PDB 5SV1 X-ray; 3.50 A; Y/Z=1-49 # PIR JV0030 BVECED # Pfam PF02472 ExbD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EXBD_ECOLI Biopolymer transport protein ExbD # RefSeq NP_417478 NC_000913.3 # RefSeq WP_001240712 NZ_LN832404.1 # SIMILARITY Belongs to the ExbD/TolR family. {ECO 0000305}. # SUBCELLULAR LOCATION EXBD_ECOLI Cell inner membrane; Single-pass type II membrane protein. # SUBUNIT EXBD_ECOLI The accessory proteins ExbB and ExbD seem to form a complex with TonB. # TCDB 1.A.30.2 the h(+)- or na(+)-translocating bacterial flagellar motor/exbbd outer membrane transport energizer (mot/exb) superfamily # TIGRFAMs TIGR02803 ExbD_1 # eggNOG COG0848 LUCA # eggNOG ENOG4108ZZF Bacteria BLAST swissprot:EXBD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EXBD_ECOLI BioCyc ECOL316407:JW2973-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2973-MONOMER BioCyc EcoCyc:EG10272-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10272-MONOMER BioCyc MetaCyc:EG10272-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10272-MONOMER COG COG0848 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0848 DIP DIP-47973N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47973N DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M28819 http://www.ebi.ac.uk/ena/data/view/M28819 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB0268 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0268 EcoGene EG10272 http://www.ecogene.org/geneInfo.php?eg_id=EG10272 EnsemblBacteria AAC76041 http://www.ensemblgenomes.org/id/AAC76041 EnsemblBacteria AAC76041 http://www.ensemblgenomes.org/id/AAC76041 EnsemblBacteria BAE77063 http://www.ensemblgenomes.org/id/BAE77063 EnsemblBacteria BAE77063 http://www.ensemblgenomes.org/id/BAE77063 EnsemblBacteria BAE77063 http://www.ensemblgenomes.org/id/BAE77063 EnsemblBacteria b3005 http://www.ensemblgenomes.org/id/b3005 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_function GO:0031992 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031992 GO_process GO:0015031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031 GO_process GO:0043213 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043213 GO_process GO:0050821 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050821 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 946345 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946345 HOGENOM HOG000134906 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000134906&db=HOGENOM6 InParanoid P0ABV2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABV2 IntAct P0ABV2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABV2* InterPro IPR003400 http://www.ebi.ac.uk/interpro/entry/IPR003400 InterPro IPR014170 http://www.ebi.ac.uk/interpro/entry/IPR014170 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2973 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2973 KEGG_Gene eco:b3005 http://www.genome.jp/dbget-bin/www_bget?eco:b3005 KEGG_Orthology KO:K03559 http://www.genome.jp/dbget-bin/www_bget?KO:K03559 OMA GIEKIGM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GIEKIGM PDB 2PFU http://www.ebi.ac.uk/pdbe-srv/view/entry/2PFU PDB 5SV1 http://www.ebi.ac.uk/pdbe-srv/view/entry/5SV1 PDBsum 2PFU http://www.ebi.ac.uk/pdbsum/2PFU PDBsum 5SV1 http://www.ebi.ac.uk/pdbsum/5SV1 PSORT swissprot:EXBD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EXBD_ECOLI PSORT-B swissprot:EXBD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EXBD_ECOLI PSORT2 swissprot:EXBD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EXBD_ECOLI Pfam PF02472 http://pfam.xfam.org/family/PF02472 Phobius swissprot:EXBD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EXBD_ECOLI PhylomeDB P0ABV2 http://phylomedb.org/?seqid=P0ABV2 ProteinModelPortal P0ABV2 http://www.proteinmodelportal.org/query/uniprot/P0ABV2 PubMed 1644779 http://www.ncbi.nlm.nih.gov/pubmed/1644779 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 2670903 http://www.ncbi.nlm.nih.gov/pubmed/2670903 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417478 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417478 RefSeq WP_001240712 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001240712 SMR P0ABV2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABV2 STRING 511145.b3005 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3005&targetmode=cogs STRING COG0848 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0848&targetmode=cogs TCDB 1.A.30.2 http://www.tcdb.org/search/result.php?tc=1.A.30.2 TIGRFAMs TIGR02803 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02803 UniProtKB EXBD_ECOLI http://www.uniprot.org/uniprot/EXBD_ECOLI UniProtKB-AC P0ABV2 http://www.uniprot.org/uniprot/P0ABV2 charge swissprot:EXBD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EXBD_ECOLI eggNOG COG0848 http://eggnogapi.embl.de/nog_data/html/tree/COG0848 eggNOG ENOG4108ZZF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZZF epestfind swissprot:EXBD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EXBD_ECOLI garnier swissprot:EXBD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EXBD_ECOLI helixturnhelix swissprot:EXBD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EXBD_ECOLI hmoment swissprot:EXBD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EXBD_ECOLI iep swissprot:EXBD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EXBD_ECOLI inforesidue swissprot:EXBD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EXBD_ECOLI octanol swissprot:EXBD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EXBD_ECOLI pepcoil swissprot:EXBD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EXBD_ECOLI pepdigest swissprot:EXBD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EXBD_ECOLI pepinfo swissprot:EXBD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EXBD_ECOLI pepnet swissprot:EXBD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EXBD_ECOLI pepstats swissprot:EXBD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EXBD_ECOLI pepwheel swissprot:EXBD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EXBD_ECOLI pepwindow swissprot:EXBD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EXBD_ECOLI sigcleave swissprot:EXBD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EXBD_ECOLI ## Database ID URL or Descriptions # BioGrid 4259913 8 # CDD cd06261 TM_PBP2 # EcoGene EG12662 gltK # FUNCTION GLTK_ECOLI Part of the ABC transporter complex GltIJKL involved in glutamate and aspartate uptake. Probably responsible for the translocation of the substrate across the membrane. {ECO 0000305|PubMed 9593292}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IEA:InterPro. # GO_function GO:0015171 amino acid transmembrane transporter activity; IBA:GO_Central. # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0022857 transmembrane transporter activity # Gene3D 1.10.3720.10 -; 1. # InterPro IPR000515 MetI-like # InterPro IPR010065 AA_ABC_transptr_permease_3TM # InterPro IPR030205 GltK/AatM # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00230 Glutamate/aspartate transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism GLTK_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30614:SF1 PTHR30614:SF1 # PATRIC 32116489 VBIEscCol129921_0684 # PIR C64800 C64800 # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Glutamate/aspartate import permease protein GltK {ECO 0000305} # RefSeq NP_415186 NC_000913.3 # RefSeq WP_000272824 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION GLTK_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255}. # SUBUNIT The complex is composed of two ATP-binding proteins (GltL), two transmembrane proteins (GltJ and GltK) and a solute- binding protein (GltI). {ECO:0000305|PubMed 9593292}. # SUPFAM SSF161098 SSF161098 # TCDB 3.A.1.3 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR01726 HEQRo_perm_3TM # eggNOG COG0765 LUCA # eggNOG ENOG4105DRP Bacteria BLAST swissprot:GLTK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLTK_ECOLI BioCyc ECOL316407:JW0648-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0648-MONOMER BioCyc EcoCyc:GLTK-MONOMER http://biocyc.org/getid?id=EcoCyc:GLTK-MONOMER BioCyc MetaCyc:GLTK-MONOMER http://biocyc.org/getid?id=MetaCyc:GLTK-MONOMER COG COG0765 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0765 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1998.00764.x http://dx.doi.org/10.1046/j.1365-2958.1998.00764.x DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U10981 http://www.ebi.ac.uk/ena/data/view/U10981 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB2528 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2528 EcoGene EG12662 http://www.ecogene.org/geneInfo.php?eg_id=EG12662 EnsemblBacteria AAC73754 http://www.ensemblgenomes.org/id/AAC73754 EnsemblBacteria AAC73754 http://www.ensemblgenomes.org/id/AAC73754 EnsemblBacteria BAA35305 http://www.ensemblgenomes.org/id/BAA35305 EnsemblBacteria BAA35305 http://www.ensemblgenomes.org/id/BAA35305 EnsemblBacteria BAA35305 http://www.ensemblgenomes.org/id/BAA35305 EnsemblBacteria b0653 http://www.ensemblgenomes.org/id/b0653 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0015171 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 947354 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947354 HOGENOM HOG000267552 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267552&db=HOGENOM6 InParanoid P0AER5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AER5 InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 InterPro IPR010065 http://www.ebi.ac.uk/interpro/entry/IPR010065 InterPro IPR030205 http://www.ebi.ac.uk/interpro/entry/IPR030205 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0648 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0648 KEGG_Gene eco:b0653 http://www.genome.jp/dbget-bin/www_bget?eco:b0653 KEGG_Orthology KO:K10002 http://www.genome.jp/dbget-bin/www_bget?KO:K10002 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA PFAWFAT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PFAWFAT PANTHER PTHR30614:SF1 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30614:SF1 PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:GLTK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLTK_ECOLI PSORT-B swissprot:GLTK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLTK_ECOLI PSORT2 swissprot:GLTK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLTK_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Phobius swissprot:GLTK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLTK_ECOLI PhylomeDB P0AER5 http://phylomedb.org/?seqid=P0AER5 ProteinModelPortal P0AER5 http://www.proteinmodelportal.org/query/uniprot/P0AER5 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9593292 http://www.ncbi.nlm.nih.gov/pubmed/9593292 RefSeq NP_415186 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415186 RefSeq WP_000272824 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000272824 SMR P0AER5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AER5 STRING 511145.b0653 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0653&targetmode=cogs STRING COG0765 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0765&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.3 http://www.tcdb.org/search/result.php?tc=3.A.1.3 TIGRFAMs TIGR01726 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01726 UniProtKB GLTK_ECOLI http://www.uniprot.org/uniprot/GLTK_ECOLI UniProtKB-AC P0AER5 http://www.uniprot.org/uniprot/P0AER5 charge swissprot:GLTK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLTK_ECOLI eggNOG COG0765 http://eggnogapi.embl.de/nog_data/html/tree/COG0765 eggNOG ENOG4105DRP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DRP epestfind swissprot:GLTK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLTK_ECOLI garnier swissprot:GLTK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLTK_ECOLI helixturnhelix swissprot:GLTK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLTK_ECOLI hmoment swissprot:GLTK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLTK_ECOLI iep swissprot:GLTK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLTK_ECOLI inforesidue swissprot:GLTK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLTK_ECOLI octanol swissprot:GLTK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLTK_ECOLI pepcoil swissprot:GLTK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLTK_ECOLI pepdigest swissprot:GLTK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLTK_ECOLI pepinfo swissprot:GLTK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLTK_ECOLI pepnet swissprot:GLTK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLTK_ECOLI pepstats swissprot:GLTK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLTK_ECOLI pepwheel swissprot:GLTK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLTK_ECOLI pepwindow swissprot:GLTK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLTK_ECOLI sigcleave swissprot:GLTK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLTK_ECOLI ## Database ID URL or Descriptions # BioGrid 4259594 11 # DISRUPTION PHENOTYPE Disruption leads to a 40-fold increase in yqjH basal expression. {ECO:0000269|PubMed 21097627}. # ENZYME REGULATION Divalent metals such as nickel and iron have a similar negative effect on YqjI DNA-binding activity. {ECO:0000269|PubMed 21097627}. # EcoGene EG12954 yqjI # FUNCTION YQJI_ECOLI Represses the expression of YqjH which is involved in iron homeostasis under excess nickel conditions. Also represses its own expression. {ECO 0000269|PubMed 21097627}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # INDUCTION Autorepressed. {ECO:0000269|PubMed 21097627}. # IntAct P64588 4 # InterPro IPR005149 Tscrpt_reg_PadR_N # InterPro IPR011991 WHTH_DNA-bd_dom # Organism YQJI_ECOLI Escherichia coli (strain K12) # PATRIC 32121558 VBIEscCol129921_3165 # PIR D65095 D65095 # Pfam PF03551 PadR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQJI_ECOLI Transcriptional regulator YqjI # RefSeq NP_417542 NC_000913.3 # RefSeq WP_000018003 NZ_LN832404.1 # SUBUNIT Oligomer (probable predominant form) and monomer. {ECO:0000269|PubMed 21097627}. # SUPFAM SSF46785 SSF46785 # eggNOG COG1695 LUCA # eggNOG ENOG4105NTW Bacteria BLAST swissprot:YQJI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQJI_ECOLI BioCyc ECOL316407:JW3042-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3042-MONOMER BioCyc EcoCyc:G7594-MONOMER http://biocyc.org/getid?id=EcoCyc:G7594-MONOMER DIP DIP-48127N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48127N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01062-10 http://dx.doi.org/10.1128/JB.01062-10 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28379 http://www.ebi.ac.uk/ena/data/view/U28379 EchoBASE EB2788 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2788 EcoGene EG12954 http://www.ecogene.org/geneInfo.php?eg_id=EG12954 EnsemblBacteria AAC76106 http://www.ensemblgenomes.org/id/AAC76106 EnsemblBacteria AAC76106 http://www.ensemblgenomes.org/id/AAC76106 EnsemblBacteria BAE77121 http://www.ensemblgenomes.org/id/BAE77121 EnsemblBacteria BAE77121 http://www.ensemblgenomes.org/id/BAE77121 EnsemblBacteria BAE77121 http://www.ensemblgenomes.org/id/BAE77121 EnsemblBacteria b3071 http://www.ensemblgenomes.org/id/b3071 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 947584 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947584 HOGENOM HOG000221100 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000221100&db=HOGENOM6 InParanoid P64588 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P64588 IntAct P64588 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P64588* InterPro IPR005149 http://www.ebi.ac.uk/interpro/entry/IPR005149 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW3042 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3042 KEGG_Gene eco:b3071 http://www.genome.jp/dbget-bin/www_bget?eco:b3071 MINT MINT-1269480 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1269480 OMA NASHGYE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NASHGYE PSORT swissprot:YQJI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQJI_ECOLI PSORT-B swissprot:YQJI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQJI_ECOLI PSORT2 swissprot:YQJI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQJI_ECOLI Pfam PF03551 http://pfam.xfam.org/family/PF03551 Phobius swissprot:YQJI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQJI_ECOLI PhylomeDB P64588 http://phylomedb.org/?seqid=P64588 ProteinModelPortal P64588 http://www.proteinmodelportal.org/query/uniprot/P64588 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21097627 http://www.ncbi.nlm.nih.gov/pubmed/21097627 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417542 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417542 RefSeq WP_000018003 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000018003 SMR P64588 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P64588 STRING 511145.b3071 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3071&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB YQJI_ECOLI http://www.uniprot.org/uniprot/YQJI_ECOLI UniProtKB-AC P64588 http://www.uniprot.org/uniprot/P64588 charge swissprot:YQJI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQJI_ECOLI eggNOG COG1695 http://eggnogapi.embl.de/nog_data/html/tree/COG1695 eggNOG ENOG4105NTW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105NTW epestfind swissprot:YQJI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQJI_ECOLI garnier swissprot:YQJI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQJI_ECOLI helixturnhelix swissprot:YQJI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQJI_ECOLI hmoment swissprot:YQJI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQJI_ECOLI iep swissprot:YQJI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQJI_ECOLI inforesidue swissprot:YQJI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQJI_ECOLI octanol swissprot:YQJI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQJI_ECOLI pepcoil swissprot:YQJI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQJI_ECOLI pepdigest swissprot:YQJI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQJI_ECOLI pepinfo swissprot:YQJI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQJI_ECOLI pepnet swissprot:YQJI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQJI_ECOLI pepstats swissprot:YQJI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQJI_ECOLI pepwheel swissprot:YQJI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQJI_ECOLI pepwindow swissprot:YQJI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQJI_ECOLI sigcleave swissprot:YQJI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQJI_ECOLI ## Database ID URL or Descriptions # BioGrid 4259244 7 # EcoGene EG12705 yggN # GO_process GO:0044010 single-species biofilm formation; IMP:EcoCyc. # GOslim_process GO:0008150 biological_process # IntAct P0ADS9 2 # InterPro IPR021307 DUF2884 # Organism YGGN_ECOLI Escherichia coli (strain K12) # PATRIC 32121328 VBIEscCol129921_3052 # PIR E65081 E65081 # Pfam PF11101 DUF2884 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGGN_ECOLI Uncharacterized protein YggN # RefSeq NP_417433 NC_000913.3 # RefSeq WP_000984796 NZ_LN832404.1 # eggNOG ENOG4105K33 Bacteria # eggNOG ENOG410XSUS LUCA BLAST swissprot:YGGN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGGN_ECOLI BioCyc ECOL316407:JW2925-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2925-MONOMER BioCyc EcoCyc:EG12705-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12705-MONOMER DOI 10.1016/0378-1119(90)90168-Q http://dx.doi.org/10.1016/0378-1119(90)90168-Q DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M34234 http://www.ebi.ac.uk/ena/data/view/M34234 EMBL M34277 http://www.ebi.ac.uk/ena/data/view/M34277 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2567 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2567 EcoGene EG12705 http://www.ecogene.org/geneInfo.php?eg_id=EG12705 EnsemblBacteria AAC75995 http://www.ensemblgenomes.org/id/AAC75995 EnsemblBacteria AAC75995 http://www.ensemblgenomes.org/id/AAC75995 EnsemblBacteria BAE77021 http://www.ensemblgenomes.org/id/BAE77021 EnsemblBacteria BAE77021 http://www.ensemblgenomes.org/id/BAE77021 EnsemblBacteria BAE77021 http://www.ensemblgenomes.org/id/BAE77021 EnsemblBacteria b2958 http://www.ensemblgenomes.org/id/b2958 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0044010 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044010 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 947453 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947453 HOGENOM HOG000124469 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000124469&db=HOGENOM6 IntAct P0ADS9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADS9* InterPro IPR021307 http://www.ebi.ac.uk/interpro/entry/IPR021307 KEGG_Gene ecj:JW2925 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2925 KEGG_Gene eco:b2958 http://www.genome.jp/dbget-bin/www_bget?eco:b2958 OMA NPLQAMM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NPLQAMM PSORT swissprot:YGGN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGGN_ECOLI PSORT-B swissprot:YGGN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGGN_ECOLI PSORT2 swissprot:YGGN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGGN_ECOLI Pfam PF11101 http://pfam.xfam.org/family/PF11101 Phobius swissprot:YGGN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGGN_ECOLI ProteinModelPortal P0ADS9 http://www.proteinmodelportal.org/query/uniprot/P0ADS9 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2144836 http://www.ncbi.nlm.nih.gov/pubmed/2144836 PubMed 2407723 http://www.ncbi.nlm.nih.gov/pubmed/2407723 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417433 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417433 RefSeq WP_000984796 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000984796 STRING 511145.b2958 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2958&targetmode=cogs UniProtKB YGGN_ECOLI http://www.uniprot.org/uniprot/YGGN_ECOLI UniProtKB-AC P0ADS9 http://www.uniprot.org/uniprot/P0ADS9 charge swissprot:YGGN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGGN_ECOLI eggNOG ENOG4105K33 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K33 eggNOG ENOG410XSUS http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XSUS epestfind swissprot:YGGN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGGN_ECOLI garnier swissprot:YGGN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGGN_ECOLI helixturnhelix swissprot:YGGN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGGN_ECOLI hmoment swissprot:YGGN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGGN_ECOLI iep swissprot:YGGN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGGN_ECOLI inforesidue swissprot:YGGN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGGN_ECOLI octanol swissprot:YGGN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGGN_ECOLI pepcoil swissprot:YGGN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGGN_ECOLI pepdigest swissprot:YGGN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGGN_ECOLI pepinfo swissprot:YGGN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGGN_ECOLI pepnet swissprot:YGGN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGGN_ECOLI pepstats swissprot:YGGN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGGN_ECOLI pepwheel swissprot:YGGN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGGN_ECOLI pepwindow swissprot:YGGN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGGN_ECOLI sigcleave swissprot:YGGN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGGN_ECOLI ## Database ID URL or Descriptions # AltName Murein peptide ligase {ECO:0000255|HAMAP-Rule MF_02020} # AltName UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase {ECO 0000255|HAMAP-Rule:MF_02020} # BIOPHYSICOCHEMICAL PROPERTIES MPL_ECOLI Kinetic parameters KM=0.25 mM for UDP-N-acetyl-alpha-D-muramate {ECO 0000269|PubMed 17384195}; KM=0.19 mM for ATP {ECO 0000269|PubMed 17384195}; KM=0.1 mM for L-alanyl-gamma-D-glutamyl-meso-2,6- diaminoheptanedioate {ECO 0000269|PubMed 17384195}; Vmax=5.8 umol/min/mg enzyme {ECO 0000269|PubMed 17384195}; Note=kcat is 290 min(-1). {ECO 0000269|PubMed 17384195}; pH dependence Optimum pH is 8.4. {ECO 0000269|PubMed 17384195}; # BRENDA 6.3.2.B21 2026 # BioGrid 4259323 187 # CATALYTIC ACTIVITY MPL_ECOLI ATP + UDP-N-acetyl-alpha-D-muramate + L- alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-meso- 2,6-diaminoheptanedioate. {ECO 0000255|HAMAP-Rule MF_02020, ECO 0000269|PubMed 17384195}. # COFACTOR MPL_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_02020, ECO 0000269|PubMed 17384195}; # DISRUPTION PHENOTYPE MPL_ECOLI Enzyme ligase activity totally absent. No effect on growth. {ECO 0000269|PubMed 17384195, ECO 0000269|PubMed 8808921}. # EcoGene EG12440 mpl # FUNCTION MPL_ECOLI Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate. The enzyme can also use the tetrapeptide L-alanyl- gamma-D-glutamyl-meso-2,6-diaminoheptanedioyl-D-alanine or the pentapeptide L-alanyl-gamma-D-glutamyl-meso-2,6- diaminoheptandioyl-D-alanyl-D-alanine in vivo and in vitro. {ECO 0000269|PubMed 17384195, ECO 0000269|PubMed 8808921}. # GO_component GO:0005576 extracellular region; IEA:UniProtKB-SubCell. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0016881 acid-amino acid ligase activity; IDA:EcoCyc. # GO_process GO:0007049 cell cycle; IEA:UniProtKB-KW. # GO_process GO:0008360 regulation of cell shape; IEA:UniProtKB-KW. # GO_process GO:0009252 peptidoglycan biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0009254 peptidoglycan turnover; IEA:UniProtKB-HAMAP. # GO_process GO:0051301 cell division; IEA:UniProtKB-KW. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005576 extracellular region # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0007049 cell cycle # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0051301 cell division # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 3.40.1190.10 -; 1. # Gene3D 3.40.50.720 -; 1. # Gene3D 3.90.190.20 -; 1. # HAMAP MF_02020 Mpl # INTERACTION MPL_ECOLI Self; NbExp=2; IntAct=EBI-562735, EBI-562735; # IntAct P37773 7 # InterPro IPR000713 Mur_ligase_N # InterPro IPR004101 Mur_ligase_C # InterPro IPR005757 Mpl # InterPro IPR013221 Mur_ligase_cen # InterPro IPR016040 NAD(P)-bd_dom # KEGG_Brite ko01000 Enzymes # Organism MPL_ECOLI Escherichia coli (strain K12) # PATHWAY MPL_ECOLI Cell wall biogenesis; peptidoglycan recycling. {ECO 0000255|HAMAP-Rule MF_02020, ECO 0000269|PubMed 8808921}. # PATRIC 32124039 VBIEscCol129921_4364 # PIR S56459 S56459 # Pfam PF01225 Mur_ligase # Pfam PF02875 Mur_ligase_C # Pfam PF08245 Mur_ligase_M # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UDP-N-acetylmuramate--L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptandioate ligase {ECO:0000255|HAMAP-Rule MF_02020} # RefSeq NP_418654 NC_000913.3 # RefSeq WP_001219813 NZ_LN832404.1 # SIMILARITY Belongs to the MurCDEF family. Mpl subfamily. {ECO:0000255|HAMAP-Rule MF_02020, ECO:0000305}. # SUBCELLULAR LOCATION MPL_ECOLI Secreted. # SUPFAM SSF53244 SSF53244 # SUPFAM SSF53623 SSF53623 # TIGRFAMs TIGR01081 mpl # eggNOG COG0773 LUCA # eggNOG ENOG4105DFU Bacteria BLAST swissprot:MPL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MPL_ECOLI BioCyc ECOL316407:JW4192-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4192-MONOMER BioCyc EcoCyc:EG12440-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12440-MONOMER BioCyc MetaCyc:EG12440-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12440-MONOMER COG COG0773 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0773 DIP DIP-10246N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10246N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/16.17.8707 http://dx.doi.org/10.1093/nar/16.17.8707 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00087-07 http://dx.doi.org/10.1128/JB.00087-07 EC_number EC:6.3.2.45 {ECO:0000255|HAMAP-Rule:MF_02020, ECO:0000269|PubMed:17384195} http://www.genome.jp/dbget-bin/www_bget?EC:6.3.2.45 {ECO:0000255|HAMAP-Rule:MF_02020, ECO:0000269|PubMed:17384195} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X12545 http://www.ebi.ac.uk/ena/data/view/X12545 ENZYME 6.3.2.45 {ECO:0000255|HAMAP-Rule:MF_02020, ECO:0000269|PubMed:17384195} http://enzyme.expasy.org/EC/6.3.2.45 {ECO:0000255|HAMAP-Rule:MF_02020, ECO:0000269|PubMed:17384195} EchoBASE EB2335 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2335 EcoGene EG12440 http://www.ecogene.org/geneInfo.php?eg_id=EG12440 EnsemblBacteria AAC77190 http://www.ensemblgenomes.org/id/AAC77190 EnsemblBacteria AAC77190 http://www.ensemblgenomes.org/id/AAC77190 EnsemblBacteria BAE78233 http://www.ensemblgenomes.org/id/BAE78233 EnsemblBacteria BAE78233 http://www.ensemblgenomes.org/id/BAE78233 EnsemblBacteria BAE78233 http://www.ensemblgenomes.org/id/BAE78233 EnsemblBacteria b4233 http://www.ensemblgenomes.org/id/b4233 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005576 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576 GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016881 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016881 GO_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0009252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009252 GO_process GO:0009254 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009254 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005576 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 3.40.1190.10 http://www.cathdb.info/version/latest/superfamily/3.40.1190.10 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 Gene3D 3.90.190.20 http://www.cathdb.info/version/latest/superfamily/3.90.190.20 GeneID 948752 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948752 HAMAP MF_02020 http://hamap.expasy.org/unirule/MF_02020 HOGENOM HOG000256032 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000256032&db=HOGENOM6 InParanoid P37773 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37773 IntAct P37773 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37773* IntEnz 6.3.2.45 {ECO:0000255|HAMAP-Rule:MF_02020, ECO:0000269|PubMed:17384195} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.2.45 {ECO:0000255|HAMAP-Rule:MF_02020, ECO:0000269|PubMed:17384195} InterPro IPR000713 http://www.ebi.ac.uk/interpro/entry/IPR000713 InterPro IPR004101 http://www.ebi.ac.uk/interpro/entry/IPR004101 InterPro IPR005757 http://www.ebi.ac.uk/interpro/entry/IPR005757 InterPro IPR013221 http://www.ebi.ac.uk/interpro/entry/IPR013221 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4192 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4192 KEGG_Gene eco:b4233 http://www.genome.jp/dbget-bin/www_bget?eco:b4233 KEGG_Orthology KO:K02558 http://www.genome.jp/dbget-bin/www_bget?KO:K02558 OMA CDANVYP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CDANVYP PSORT swissprot:MPL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MPL_ECOLI PSORT-B swissprot:MPL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MPL_ECOLI PSORT2 swissprot:MPL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MPL_ECOLI Pfam PF01225 http://pfam.xfam.org/family/PF01225 Pfam PF02875 http://pfam.xfam.org/family/PF02875 Pfam PF08245 http://pfam.xfam.org/family/PF08245 Phobius swissprot:MPL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MPL_ECOLI PhylomeDB P37773 http://phylomedb.org/?seqid=P37773 ProteinModelPortal P37773 http://www.proteinmodelportal.org/query/uniprot/P37773 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17384195 http://www.ncbi.nlm.nih.gov/pubmed/17384195 PubMed 2843822 http://www.ncbi.nlm.nih.gov/pubmed/2843822 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 8808921 http://www.ncbi.nlm.nih.gov/pubmed/8808921 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418654 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418654 RefSeq WP_001219813 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001219813 SMR P37773 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37773 STRING 511145.b4233 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4233&targetmode=cogs STRING COG0773 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0773&targetmode=cogs SUPFAM SSF53244 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53244 SUPFAM SSF53623 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53623 TIGRFAMs TIGR01081 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01081 UniProtKB MPL_ECOLI http://www.uniprot.org/uniprot/MPL_ECOLI UniProtKB-AC P37773 http://www.uniprot.org/uniprot/P37773 charge swissprot:MPL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MPL_ECOLI eggNOG COG0773 http://eggnogapi.embl.de/nog_data/html/tree/COG0773 eggNOG ENOG4105DFU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DFU epestfind swissprot:MPL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MPL_ECOLI garnier swissprot:MPL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MPL_ECOLI helixturnhelix swissprot:MPL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MPL_ECOLI hmoment swissprot:MPL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MPL_ECOLI iep swissprot:MPL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MPL_ECOLI inforesidue swissprot:MPL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MPL_ECOLI octanol swissprot:MPL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MPL_ECOLI pepcoil swissprot:MPL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MPL_ECOLI pepdigest swissprot:MPL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MPL_ECOLI pepinfo swissprot:MPL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MPL_ECOLI pepnet swissprot:MPL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MPL_ECOLI pepstats swissprot:MPL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MPL_ECOLI pepwheel swissprot:MPL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MPL_ECOLI pepwindow swissprot:MPL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MPL_ECOLI sigcleave swissprot:MPL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MPL_ECOLI ## Database ID URL or Descriptions # BioGrid 4260297 16 # EcoGene EG12391 ydiE # IntAct P0ACX9 17 # InterPro IPR019600 Hemin_uptake_protein_HemP # Organism YDIE_ECOLI Escherichia coli (strain K12) # PATRIC 32118716 VBIEscCol129921_1776 # PDB 4YNX X-ray; 1.50 A; A/B=1-63 # PIR A64929 A64929 # Pfam PF10636 hemP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDIE_ECOLI Uncharacterized protein YdiE # RefSeq NP_416220 NC_000913.3 # RefSeq WP_001270809 NZ_LN832404.1 # SIMILARITY To Y.enterocolitica HemP. {ECO 0000305}. # eggNOG COG4256 LUCA BLAST swissprot:YDIE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDIE_ECOLI BioCyc ECOL316407:JW1695-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1695-MONOMER BioCyc EcoCyc:EG12391-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12391-MONOMER DOI 10.1016/0378-1119(91)90544-L http://dx.doi.org/10.1016/0378-1119(91)90544-L DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M38266 http://www.ebi.ac.uk/ena/data/view/M38266 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2292 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2292 EcoGene EG12391 http://www.ecogene.org/geneInfo.php?eg_id=EG12391 EnsemblBacteria AAC74775 http://www.ensemblgenomes.org/id/AAC74775 EnsemblBacteria AAC74775 http://www.ensemblgenomes.org/id/AAC74775 EnsemblBacteria BAA15474 http://www.ensemblgenomes.org/id/BAA15474 EnsemblBacteria BAA15474 http://www.ensemblgenomes.org/id/BAA15474 EnsemblBacteria BAA15474 http://www.ensemblgenomes.org/id/BAA15474 EnsemblBacteria b1705 http://www.ensemblgenomes.org/id/b1705 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946205 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946205 HOGENOM HOG000262430 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000262430&db=HOGENOM6 IntAct P0ACX9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACX9* InterPro IPR019600 http://www.ebi.ac.uk/interpro/entry/IPR019600 KEGG_Gene ecj:JW1695 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1695 KEGG_Gene eco:b1705 http://www.genome.jp/dbget-bin/www_bget?eco:b1705 OMA KFTPETD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KFTPETD PDB 4YNX http://www.ebi.ac.uk/pdbe-srv/view/entry/4YNX PDBsum 4YNX http://www.ebi.ac.uk/pdbsum/4YNX PSORT swissprot:YDIE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDIE_ECOLI PSORT-B swissprot:YDIE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDIE_ECOLI PSORT2 swissprot:YDIE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDIE_ECOLI Pfam PF10636 http://pfam.xfam.org/family/PF10636 Phobius swissprot:YDIE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDIE_ECOLI ProteinModelPortal P0ACX9 http://www.proteinmodelportal.org/query/uniprot/P0ACX9 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1677907 http://www.ncbi.nlm.nih.gov/pubmed/1677907 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416220 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416220 RefSeq WP_001270809 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001270809 SMR P0ACX9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACX9 STRING 511145.b1705 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1705&targetmode=cogs UniProtKB YDIE_ECOLI http://www.uniprot.org/uniprot/YDIE_ECOLI UniProtKB-AC P0ACX9 http://www.uniprot.org/uniprot/P0ACX9 charge swissprot:YDIE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDIE_ECOLI eggNOG COG4256 http://eggnogapi.embl.de/nog_data/html/tree/COG4256 epestfind swissprot:YDIE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDIE_ECOLI garnier swissprot:YDIE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDIE_ECOLI helixturnhelix swissprot:YDIE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDIE_ECOLI hmoment swissprot:YDIE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDIE_ECOLI iep swissprot:YDIE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDIE_ECOLI inforesidue swissprot:YDIE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDIE_ECOLI octanol swissprot:YDIE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDIE_ECOLI pepcoil swissprot:YDIE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDIE_ECOLI pepdigest swissprot:YDIE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDIE_ECOLI pepinfo swissprot:YDIE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDIE_ECOLI pepnet swissprot:YDIE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDIE_ECOLI pepstats swissprot:YDIE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDIE_ECOLI pepwheel swissprot:YDIE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDIE_ECOLI pepwindow swissprot:YDIE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDIE_ECOLI sigcleave swissprot:YDIE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDIE_ECOLI ## Database ID URL or Descriptions # AltName FECA_ECOLI Iron(III) dicitrate transport protein FecA # BioGrid 4261554 298 # EcoGene EG10286 fecA # FUNCTION FECA_ECOLI FecA is the outer membrane receptor protein in the Fe(3+) dicitrate transport system. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0004872 receptor activity; IEA:InterPro. # GO_function GO:0005506 iron ion binding; IEA:InterPro. # GO_function GO:0015091 ferric iron transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0015682 ferric iron transport; IMP:EcoCyc. # GO_process GO:0015891 siderophore transport; IEA:InterPro. # GO_process GO:0055072 iron ion homeostasis; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # GOslim_process GO:0042592 homeostatic process # Gene3D 2.170.130.10 -; 1. # Gene3D 2.40.170.20 -; 1. # INDUCTION For induction, the TonB and the ExbB proteins have to be active. Regulation by the iron level mediated by the Fur protein and induction by citrate plus iron suggest that the Fe(3+) dicitrate complex must enter the periplasm where it binds to a transmembrane protein, which regulates transcription of the fec genes directly or via a further inductor. Induced 2-fold by hydroxyurea (PubMed:20005847). {ECO 0000269|PubMed:20005847}. # IntAct P13036 3 # InterPro IPR000531 TonB-dep_rcpt_b-brl # InterPro IPR010105 TonB_sidphr_rcpt # InterPro IPR010916 TonB_box_CS # InterPro IPR010917 TonB_rcpt_CS # InterPro IPR011662 Secretin/TonB_short_N # InterPro IPR012910 Plug_dom # KEGG_Brite ko02000 Transporters # Organism FECA_ECOLI Escherichia coli (strain K12) # PATRIC 32124161 VBIEscCol129921_4424 # PDB 1KMO X-ray; 2.00 A; A=1-774 # PDB 1KMP X-ray; 2.50 A; A=1-774 # PDB 1PNZ X-ray; 2.50 A; A=34-774 # PDB 1PO0 X-ray; 2.15 A; A=34-774 # PDB 1PO3 X-ray; 3.40 A; A/B=34-774 # PDB 1ZZV NMR; -; A=34-113 # PDB 2D1U NMR; -; A=34-129 # PIR E65242 QRECFA # PROSITE PS00430 TONB_DEPENDENT_REC_1 # PROSITE PS01156 TONB_DEPENDENT_REC_2 # Pfam PF00593 TonB_dep_Rec # Pfam PF07660 STN # Pfam PF07715 Plug # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FECA_ECOLI Fe(3+) dicitrate transport protein FecA # RefSeq NP_418711 NC_000913.3 # RefSeq WP_000188283 NZ_LN832404.1 # SIMILARITY Belongs to the TonB-dependent receptor family. {ECO 0000305}. # SMART SM00965 STN # SUBCELLULAR LOCATION FECA_ECOLI Cell outer membrane. # TCDB 1.B.14.1.20 the outer membrane receptor (omr) family # TIGRFAMs TIGR01783 TonB-siderophor # eggNOG COG4772 LUCA # eggNOG ENOG4105GAV Bacteria BLAST swissprot:FECA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FECA_ECOLI BioCyc ECOL316407:JW4251-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4251-MONOMER BioCyc EcoCyc:EG10286-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10286-MONOMER BioCyc MetaCyc:EG10286-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10286-MONOMER COG COG4772 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4772 DIP DIP-9583N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9583N DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M20981 http://www.ebi.ac.uk/ena/data/view/M20981 EMBL M26397 http://www.ebi.ac.uk/ena/data/view/M26397 EMBL M63115 http://www.ebi.ac.uk/ena/data/view/M63115 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB0282 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0282 EcoGene EG10286 http://www.ecogene.org/geneInfo.php?eg_id=EG10286 EnsemblBacteria AAC77247 http://www.ensemblgenomes.org/id/AAC77247 EnsemblBacteria AAC77247 http://www.ensemblgenomes.org/id/AAC77247 EnsemblBacteria BAE78282 http://www.ensemblgenomes.org/id/BAE78282 EnsemblBacteria BAE78282 http://www.ensemblgenomes.org/id/BAE78282 EnsemblBacteria BAE78282 http://www.ensemblgenomes.org/id/BAE78282 EnsemblBacteria b4291 http://www.ensemblgenomes.org/id/b4291 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0004872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004872 GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0015091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015091 GO_process GO:0015682 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015682 GO_process GO:0015891 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015891 GO_process GO:0055072 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055072 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 Gene3D 2.170.130.10 http://www.cathdb.info/version/latest/superfamily/2.170.130.10 Gene3D 2.40.170.20 http://www.cathdb.info/version/latest/superfamily/2.40.170.20 GeneID 946427 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946427 HOGENOM HOG000219169 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219169&db=HOGENOM6 InParanoid P13036 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P13036 IntAct P13036 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P13036* InterPro IPR000531 http://www.ebi.ac.uk/interpro/entry/IPR000531 InterPro IPR010105 http://www.ebi.ac.uk/interpro/entry/IPR010105 InterPro IPR010916 http://www.ebi.ac.uk/interpro/entry/IPR010916 InterPro IPR010917 http://www.ebi.ac.uk/interpro/entry/IPR010917 InterPro IPR011662 http://www.ebi.ac.uk/interpro/entry/IPR011662 InterPro IPR012910 http://www.ebi.ac.uk/interpro/entry/IPR012910 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW4251 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4251 KEGG_Gene eco:b4291 http://www.genome.jp/dbget-bin/www_bget?eco:b4291 KEGG_Orthology KO:K16091 http://www.genome.jp/dbget-bin/www_bget?KO:K16091 MINT MINT-119307 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-119307 OMA QYESNQT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QYESNQT PDB 1KMO http://www.ebi.ac.uk/pdbe-srv/view/entry/1KMO PDB 1KMP http://www.ebi.ac.uk/pdbe-srv/view/entry/1KMP PDB 1PNZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1PNZ PDB 1PO0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1PO0 PDB 1PO3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1PO3 PDB 1ZZV http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZZV PDB 2D1U http://www.ebi.ac.uk/pdbe-srv/view/entry/2D1U PDBsum 1KMO http://www.ebi.ac.uk/pdbsum/1KMO PDBsum 1KMP http://www.ebi.ac.uk/pdbsum/1KMP PDBsum 1PNZ http://www.ebi.ac.uk/pdbsum/1PNZ PDBsum 1PO0 http://www.ebi.ac.uk/pdbsum/1PO0 PDBsum 1PO3 http://www.ebi.ac.uk/pdbsum/1PO3 PDBsum 1ZZV http://www.ebi.ac.uk/pdbsum/1ZZV PDBsum 2D1U http://www.ebi.ac.uk/pdbsum/2D1U PROSITE PS00430 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00430 PROSITE PS01156 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01156 PSORT swissprot:FECA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FECA_ECOLI PSORT-B swissprot:FECA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FECA_ECOLI PSORT2 swissprot:FECA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FECA_ECOLI Pfam PF00593 http://pfam.xfam.org/family/PF00593 Pfam PF07660 http://pfam.xfam.org/family/PF07660 Pfam PF07715 http://pfam.xfam.org/family/PF07715 Phobius swissprot:FECA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FECA_ECOLI PhylomeDB P13036 http://phylomedb.org/?seqid=P13036 ProteinModelPortal P13036 http://www.proteinmodelportal.org/query/uniprot/P13036 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 2254251 http://www.ncbi.nlm.nih.gov/pubmed/2254251 PubMed 2651410 http://www.ncbi.nlm.nih.gov/pubmed/2651410 PubMed 2836368 http://www.ncbi.nlm.nih.gov/pubmed/2836368 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418711 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418711 RefSeq WP_000188283 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000188283 SMART SM00965 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00965 SMR P13036 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P13036 STRING 511145.b4291 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4291&targetmode=cogs STRING COG4772 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4772&targetmode=cogs TCDB 1.B.14.1.20 http://www.tcdb.org/search/result.php?tc=1.B.14.1.20 TIGRFAMs TIGR01783 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01783 UniProtKB FECA_ECOLI http://www.uniprot.org/uniprot/FECA_ECOLI UniProtKB-AC P13036 http://www.uniprot.org/uniprot/P13036 charge swissprot:FECA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FECA_ECOLI eggNOG COG4772 http://eggnogapi.embl.de/nog_data/html/tree/COG4772 eggNOG ENOG4105GAV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105GAV epestfind swissprot:FECA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FECA_ECOLI garnier swissprot:FECA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FECA_ECOLI helixturnhelix swissprot:FECA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FECA_ECOLI hmoment swissprot:FECA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FECA_ECOLI iep swissprot:FECA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FECA_ECOLI inforesidue swissprot:FECA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FECA_ECOLI octanol swissprot:FECA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FECA_ECOLI pepcoil swissprot:FECA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FECA_ECOLI pepdigest swissprot:FECA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FECA_ECOLI pepinfo swissprot:FECA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FECA_ECOLI pepnet swissprot:FECA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FECA_ECOLI pepstats swissprot:FECA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FECA_ECOLI pepwheel swissprot:FECA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FECA_ECOLI pepwindow swissprot:FECA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FECA_ECOLI sigcleave swissprot:FECA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FECA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261143 13 # CDD cd06170 LuxR_C_like # EcoGene EG11889 dctR # FUNCTION DCTR_ECOLI May act as a transcriptional regulator of dctA. {ECO 0000269|PubMed 9811641}. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0043471 regulation of cellular carbohydrate catabolic process; IGI:EcoCyc. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # INDUCTION DCTR_ECOLI By acidic conditions. Could be induced by EvgA via the induction of YdeO. {ECO 0000269|PubMed 12399493, ECO 0000269|PubMed 12694615}. # IntAct P37195 10 # InterPro IPR000792 Tscrpt_reg_LuxR_C # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR016032 Sig_transdc_resp-reg_C-effctor # MISCELLANEOUS DCTR_ECOLI Overexpression causes filamentous biofilm formation. # Organism DCTR_ECOLI Escherichia coli (strain K12) # PATRIC 32122472 VBIEscCol129921_3614 # PIR S47727 S47727 # PROSITE PS50043 HTH_LUXR_2 # Pfam PF00196 GerE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DCTR_ECOLI HTH-type transcriptional regulator DctR # RefSeq NP_417964 NC_000913.3 # RefSeq WP_000478619 NZ_LN832404.1 # SIMILARITY Contains 1 HTH luxR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00411}. # SMART SM00421 HTH_LUXR # SUPFAM SSF46894 SSF46894 # eggNOG COG2771 LUCA BLAST swissprot:DCTR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DCTR_ECOLI BioCyc ECOL316407:JW3475-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3475-MONOMER BioCyc EcoCyc:EG11889-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11889-MONOMER DIP DIP-12362N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12362N DOI 10.1016/S0378-1097(03)00507-X http://dx.doi.org/10.1016/S0378-1097(03)00507-X DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2003.03477.x http://dx.doi.org/10.1046/j.1365-2958.2003.03477.x DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1111/j.1365-2958.1994.tb00383.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb00383.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.22.6225-6234.2002 http://dx.doi.org/10.1128/JB.184.22.6225-6234.2002 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L23635 http://www.ebi.ac.uk/ena/data/view/L23635 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1835 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1835 EcoGene EG11889 http://www.ecogene.org/geneInfo.php?eg_id=EG11889 EnsemblBacteria AAC76532 http://www.ensemblgenomes.org/id/AAC76532 EnsemblBacteria AAC76532 http://www.ensemblgenomes.org/id/AAC76532 EnsemblBacteria BAE77787 http://www.ensemblgenomes.org/id/BAE77787 EnsemblBacteria BAE77787 http://www.ensemblgenomes.org/id/BAE77787 EnsemblBacteria BAE77787 http://www.ensemblgenomes.org/id/BAE77787 EnsemblBacteria b3507 http://www.ensemblgenomes.org/id/b3507 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0043471 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043471 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 948021 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948021 HOGENOM HOG000125804 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125804&db=HOGENOM6 IntAct P37195 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37195* InterPro IPR000792 http://www.ebi.ac.uk/interpro/entry/IPR000792 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR016032 http://www.ebi.ac.uk/interpro/entry/IPR016032 KEGG_Gene ecj:JW3475 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3475 KEGG_Gene eco:b3507 http://www.genome.jp/dbget-bin/www_bget?eco:b3507 OMA APEADIM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=APEADIM PROSITE PS50043 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50043 PSORT swissprot:DCTR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DCTR_ECOLI PSORT-B swissprot:DCTR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DCTR_ECOLI PSORT2 swissprot:DCTR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DCTR_ECOLI Pfam PF00196 http://pfam.xfam.org/family/PF00196 Phobius swissprot:DCTR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DCTR_ECOLI ProteinModelPortal P37195 http://www.proteinmodelportal.org/query/uniprot/P37195 PubMed 12399493 http://www.ncbi.nlm.nih.gov/pubmed/12399493 PubMed 12694615 http://www.ncbi.nlm.nih.gov/pubmed/12694615 PubMed 12900028 http://www.ncbi.nlm.nih.gov/pubmed/12900028 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8022277 http://www.ncbi.nlm.nih.gov/pubmed/8022277 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9811641 http://www.ncbi.nlm.nih.gov/pubmed/9811641 RefSeq NP_417964 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417964 RefSeq WP_000478619 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000478619 SMART SM00421 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00421 SMR P37195 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37195 STRING 511145.b3507 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3507&targetmode=cogs SUPFAM SSF46894 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46894 UniProtKB DCTR_ECOLI http://www.uniprot.org/uniprot/DCTR_ECOLI UniProtKB-AC P37195 http://www.uniprot.org/uniprot/P37195 charge swissprot:DCTR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DCTR_ECOLI eggNOG COG2771 http://eggnogapi.embl.de/nog_data/html/tree/COG2771 epestfind swissprot:DCTR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DCTR_ECOLI garnier swissprot:DCTR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DCTR_ECOLI helixturnhelix swissprot:DCTR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DCTR_ECOLI hmoment swissprot:DCTR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DCTR_ECOLI iep swissprot:DCTR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DCTR_ECOLI inforesidue swissprot:DCTR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DCTR_ECOLI octanol swissprot:DCTR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DCTR_ECOLI pepcoil swissprot:DCTR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DCTR_ECOLI pepdigest swissprot:DCTR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DCTR_ECOLI pepinfo swissprot:DCTR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DCTR_ECOLI pepnet swissprot:DCTR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DCTR_ECOLI pepstats swissprot:DCTR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DCTR_ECOLI pepwheel swissprot:DCTR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DCTR_ECOLI pepwindow swissprot:DCTR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DCTR_ECOLI sigcleave swissprot:DCTR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DCTR_ECOLI ## Database ID URL or Descriptions # AltName Multidrug transporter MdtC {ECO:0000255|HAMAP-Rule MF_01424} # BioGrid 4260422 155 # EcoGene EG14058 mdtC # FUNCTION MDTC_ECOLI The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate. MdtABC requires TolC for its function. {ECO 0000255|HAMAP-Rule MF_01424, ECO 0000269|PubMed 12107133, ECO 0000269|PubMed 12107134}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_function MDTC_ECOLI GO 0015307 drug proton antiporter activity; IDA EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # Gene3D 3.30.2090.10 -; 2. # HAMAP MF_01424 MdtC # INDUCTION MDTC_ECOLI The mdtABC operon is transcriptionally activated by BaeR. {ECO 0000255|HAMAP-Rule MF_01424, ECO 0000269|PubMed 12107133, ECO 0000269|PubMed 12107134}. # INTERACTION MDTC_ECOLI P76398 mdtB; NbExp=3; IntAct=EBI-1116694, EBI-561416; # IntAct P76399 4 # InterPro IPR001036 Acrflvin-R # InterPro IPR023931 Multidrug-R_MdtC # InterPro IPR027463 AcrB_DN_DC_subdom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko02020 Two-component system # Organism MDTC_ECOLI Escherichia coli (strain K12) # PATRIC 32119485 VBIEscCol129921_2153 # PIR C64974 C64974 # PRINTS PR00702 ACRIFLAVINRP # Pfam PF00873 ACR_tran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Multidrug resistance protein MdtC {ECO:0000255|HAMAP-Rule MF_01424} # RefSeq NP_416580 NC_000913.3 # RefSeq WP_000667481 NZ_LN832404.1 # SIMILARITY Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtC subfamily. {ECO:0000255|HAMAP- Rule MF_01424}. # SUBCELLULAR LOCATION MDTC_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT MDTC_ECOLI Part of a tripartite efflux system composed of MdtA, MdtB and MdtC. MdtC forms a heteromultimer with MdtB. # SUPFAM SSF82714 SSF82714; 2 # TCDB 2.A.6.2.12 the resistance-nodulation-cell division (rnd) superfamily # eggNOG COG0841 LUCA # eggNOG ENOG4105BZS Bacteria BLAST swissprot:MDTC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MDTC_ECOLI BioCyc ECOL316407:JW2061-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2061-MONOMER BioCyc EcoCyc:B2076-MONOMER http://biocyc.org/getid?id=EcoCyc:B2076-MONOMER COG COG0841 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0841 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.15.4161-4167.2002 http://dx.doi.org/10.1128/JB.184.15.4161-4167.2002 DOI 10.1128/JB.184.15.4168-4176.2002 http://dx.doi.org/10.1128/JB.184.15.4168-4176.2002 EMBL AB089189 http://www.ebi.ac.uk/ena/data/view/AB089189 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3811 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3811 EcoGene EG14058 http://www.ecogene.org/geneInfo.php?eg_id=EG14058 EnsemblBacteria AAC75137 http://www.ensemblgenomes.org/id/AAC75137 EnsemblBacteria AAC75137 http://www.ensemblgenomes.org/id/AAC75137 EnsemblBacteria BAA15932 http://www.ensemblgenomes.org/id/BAA15932 EnsemblBacteria BAA15932 http://www.ensemblgenomes.org/id/BAA15932 EnsemblBacteria BAA15932 http://www.ensemblgenomes.org/id/BAA15932 EnsemblBacteria b2076 http://www.ensemblgenomes.org/id/b2076 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015307 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015307 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 Gene3D 3.30.2090.10 http://www.cathdb.info/version/latest/superfamily/3.30.2090.10 GeneID 946608 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946608 HAMAP MF_01424 http://hamap.expasy.org/unirule/MF_01424 HOGENOM HOG000158127 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000158127&db=HOGENOM6 InParanoid P76399 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76399 IntAct P76399 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76399* InterPro IPR001036 http://www.ebi.ac.uk/interpro/entry/IPR001036 InterPro IPR023931 http://www.ebi.ac.uk/interpro/entry/IPR023931 InterPro IPR027463 http://www.ebi.ac.uk/interpro/entry/IPR027463 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW2061 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2061 KEGG_Gene eco:b2076 http://www.genome.jp/dbget-bin/www_bget?eco:b2076 KEGG_Orthology KO:K07789 http://www.genome.jp/dbget-bin/www_bget?KO:K07789 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA MFVINSD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MFVINSD PRINTS PR00702 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00702 PSORT swissprot:MDTC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MDTC_ECOLI PSORT-B swissprot:MDTC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MDTC_ECOLI PSORT2 swissprot:MDTC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MDTC_ECOLI Pfam PF00873 http://pfam.xfam.org/family/PF00873 Phobius swissprot:MDTC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MDTC_ECOLI PhylomeDB P76399 http://phylomedb.org/?seqid=P76399 ProteinModelPortal P76399 http://www.proteinmodelportal.org/query/uniprot/P76399 PubMed 12107133 http://www.ncbi.nlm.nih.gov/pubmed/12107133 PubMed 12107134 http://www.ncbi.nlm.nih.gov/pubmed/12107134 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416580 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416580 RefSeq WP_000667481 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000667481 SMR P76399 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76399 STRING 511145.b2076 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2076&targetmode=cogs STRING COG0841 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0841&targetmode=cogs SUPFAM SSF82714 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF82714 TCDB 2.A.6.2.12 http://www.tcdb.org/search/result.php?tc=2.A.6.2.12 UniProtKB MDTC_ECOLI http://www.uniprot.org/uniprot/MDTC_ECOLI UniProtKB-AC P76399 http://www.uniprot.org/uniprot/P76399 charge swissprot:MDTC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MDTC_ECOLI eggNOG COG0841 http://eggnogapi.embl.de/nog_data/html/tree/COG0841 eggNOG ENOG4105BZS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZS epestfind swissprot:MDTC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MDTC_ECOLI garnier swissprot:MDTC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MDTC_ECOLI helixturnhelix swissprot:MDTC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MDTC_ECOLI hmoment swissprot:MDTC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MDTC_ECOLI iep swissprot:MDTC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MDTC_ECOLI inforesidue swissprot:MDTC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MDTC_ECOLI octanol swissprot:MDTC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MDTC_ECOLI pepcoil swissprot:MDTC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MDTC_ECOLI pepdigest swissprot:MDTC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MDTC_ECOLI pepinfo swissprot:MDTC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MDTC_ECOLI pepnet swissprot:MDTC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MDTC_ECOLI pepstats swissprot:MDTC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MDTC_ECOLI pepwheel swissprot:MDTC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MDTC_ECOLI pepwindow swissprot:MDTC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MDTC_ECOLI sigcleave swissprot:MDTC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MDTC_ECOLI ## Database ID URL or Descriptions # AltName PRPE_ECOLI Propionyl-CoA synthetase # BioGrid 4259811 7 # CATALYTIC ACTIVITY PRPE_ECOLI ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA. # EcoGene EG13604 prpE # FUNCTION PRPE_ECOLI Catalyzes the synthesis of propionyl-CoA from propionate and CoA. Also converts acetate to acetyl-CoA but with a lower specific activity (By similarity). {ECO 0000250}. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0050218 propionate-CoA ligase activity; IDA:EcoCyc. # GO_process GO:0019629 propionate catabolic process, 2-methylcitrate cycle; IEA:InterPro. # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # IntAct P77495 7 # InterPro IPR000873 AMP-dep_Synth/Lig # InterPro IPR012694 Propion_PrpE # InterPro IPR020845 AMP-binding_CS # InterPro IPR025110 AMP-bd_C # InterPro IPR032387 ACAS_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01004 Lipid biosynthesis proteins # KEGG_Pathway ko00640 Propanoate metabolism # Organism PRPE_ECOLI Escherichia coli (strain K12) # PATHWAY PRPE_ECOLI Organic acid metabolism; propanoate degradation. # PATRIC 32115801 VBIEscCol129921_0342 # PIR G64760 G64760 # PROSITE PS00455 AMP_BINDING # Pfam PF00501 AMP-binding # Pfam PF13193 AMP-binding_C # Pfam PF16177 ACAS_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PRPE_ECOLI Propionate--CoA ligase # RefSeq NP_414869 NC_000913.3 # RefSeq WP_000010288 NZ_LN832404.1 # SIMILARITY Belongs to the ATP-dependent AMP-binding enzyme family. {ECO 0000305}. # TIGRFAMs TIGR02316 propion_prpE # eggNOG COG0365 LUCA # eggNOG ENOG4108IQF Bacteria BLAST swissprot:PRPE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PRPE_ECOLI BioCyc ECOL316407:JW0326-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0326-MONOMER BioCyc EcoCyc:G6200-MONOMER http://biocyc.org/getid?id=EcoCyc:G6200-MONOMER BioCyc MetaCyc:G6200-MONOMER http://biocyc.org/getid?id=MetaCyc:G6200-MONOMER COG COG0365 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0365 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.2.1.17 http://www.genome.jp/dbget-bin/www_bget?EC:6.2.1.17 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 ENZYME 6.2.1.17 http://enzyme.expasy.org/EC/6.2.1.17 EchoBASE EB3372 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3372 EcoGene EG13604 http://www.ecogene.org/geneInfo.php?eg_id=EG13604 EnsemblBacteria AAC73438 http://www.ensemblgenomes.org/id/AAC73438 EnsemblBacteria AAC73438 http://www.ensemblgenomes.org/id/AAC73438 EnsemblBacteria BAE76117 http://www.ensemblgenomes.org/id/BAE76117 EnsemblBacteria BAE76117 http://www.ensemblgenomes.org/id/BAE76117 EnsemblBacteria BAE76117 http://www.ensemblgenomes.org/id/BAE76117 EnsemblBacteria b0335 http://www.ensemblgenomes.org/id/b0335 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0050218 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050218 GO_process GO:0019629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019629 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 946891 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946891 HOGENOM HOG000229981 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000229981&db=HOGENOM6 InParanoid P77495 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77495 IntAct P77495 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77495* IntEnz 6.2.1.17 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.2.1.17 InterPro IPR000873 http://www.ebi.ac.uk/interpro/entry/IPR000873 InterPro IPR012694 http://www.ebi.ac.uk/interpro/entry/IPR012694 InterPro IPR020845 http://www.ebi.ac.uk/interpro/entry/IPR020845 InterPro IPR025110 http://www.ebi.ac.uk/interpro/entry/IPR025110 InterPro IPR032387 http://www.ebi.ac.uk/interpro/entry/IPR032387 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01004 http://www.genome.jp/dbget-bin/www_bget?ko01004 KEGG_Gene ecj:JW0326 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0326 KEGG_Gene eco:b0335 http://www.genome.jp/dbget-bin/www_bget?eco:b0335 KEGG_Orthology KO:K01908 http://www.genome.jp/dbget-bin/www_bget?KO:K01908 KEGG_Pathway ko00640 http://www.genome.jp/kegg-bin/show_pathway?ko00640 KEGG_Reaction rn:R00926 http://www.genome.jp/dbget-bin/www_bget?rn:R00926 KEGG_Reaction rn:R01354 http://www.genome.jp/dbget-bin/www_bget?rn:R01354 OMA LPVKHGS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LPVKHGS PROSITE PS00455 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00455 PSORT swissprot:PRPE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PRPE_ECOLI PSORT-B swissprot:PRPE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PRPE_ECOLI PSORT2 swissprot:PRPE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PRPE_ECOLI Pfam PF00501 http://pfam.xfam.org/family/PF00501 Pfam PF13193 http://pfam.xfam.org/family/PF13193 Pfam PF16177 http://pfam.xfam.org/family/PF16177 Phobius swissprot:PRPE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PRPE_ECOLI PhylomeDB P77495 http://phylomedb.org/?seqid=P77495 ProteinModelPortal P77495 http://www.proteinmodelportal.org/query/uniprot/P77495 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414869 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414869 RefSeq WP_000010288 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000010288 SMR P77495 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77495 STRING 511145.b0335 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0335&targetmode=cogs STRING COG0365 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0365&targetmode=cogs TIGRFAMs TIGR02316 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02316 UniProtKB PRPE_ECOLI http://www.uniprot.org/uniprot/PRPE_ECOLI UniProtKB-AC P77495 http://www.uniprot.org/uniprot/P77495 charge swissprot:PRPE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PRPE_ECOLI eggNOG COG0365 http://eggnogapi.embl.de/nog_data/html/tree/COG0365 eggNOG ENOG4108IQF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108IQF epestfind swissprot:PRPE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PRPE_ECOLI garnier swissprot:PRPE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PRPE_ECOLI helixturnhelix swissprot:PRPE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PRPE_ECOLI hmoment swissprot:PRPE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PRPE_ECOLI iep swissprot:PRPE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PRPE_ECOLI inforesidue swissprot:PRPE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PRPE_ECOLI octanol swissprot:PRPE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PRPE_ECOLI pepcoil swissprot:PRPE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PRPE_ECOLI pepdigest swissprot:PRPE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PRPE_ECOLI pepinfo swissprot:PRPE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PRPE_ECOLI pepnet swissprot:PRPE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PRPE_ECOLI pepstats swissprot:PRPE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PRPE_ECOLI pepwheel swissprot:PRPE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PRPE_ECOLI pepwindow swissprot:PRPE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PRPE_ECOLI sigcleave swissprot:PRPE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PRPE_ECOLI ## Database ID URL or Descriptions # AltName UPPP_ECOLI Bacitracin resistance protein # AltName UPPP_ECOLI Undecaprenyl pyrophosphate phosphatase # BRENDA 3.6.1.27 2026 # BioGrid 4261190 233 # CATALYTIC ACTIVITY Ditrans,octacis-undecaprenyl diphosphate + H(2)O = ditrans,octacis-undecaprenyl phosphate + phosphate. {ECO:0000269|PubMed 15138271}. # CAUTION Was originally thought to be an undecaprenol kinase. {ECO:0000305|PubMed 8389741}. # EcoGene EG11665 uppP # FUNCTION UPPP_ECOLI Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin. {ECO 0000269|PubMed 15778224}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0050380 undecaprenyl-diphosphatase activity; IDA:EcoliWiki. # GO_process GO:0008360 regulation of cell shape; IEA:UniProtKB-KW. # GO_process GO:0009252 peptidoglycan biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0016311 dephosphorylation; IEA:InterPro. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-HAMAP. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0071554 cell wall organization or biogenesis # HAMAP MF_01006 Undec_diphosphatase # InterPro IPR003824 UppP # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00550 Peptidoglycan biosynthesis # MISCELLANEOUS UPPP_ECOLI Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. # Organism UPPP_ECOLI Escherichia coli (strain K12) # PATRIC 32121526 VBIEscCol129921_3150 # PIR G65093 G65093 # Pfam PF02673 BacA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UPPP_ECOLI Undecaprenyl-diphosphatase # RefSeq NP_417529 NC_000913.3 # RefSeq WP_001281927 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=L12966; Type=Frameshift; Positions=145; Evidence={ECO:0000305}; Sequence=M12788; Type=Frameshift; Positions=177, 210; Evidence={ECO 0000305}; # SIMILARITY Belongs to the UppP family. {ECO 0000305}. # SUBCELLULAR LOCATION UPPP_ECOLI Cell inner membrane {ECO 0000269|PubMed 15138271, ECO 0000269|PubMed 15919996}; Multi- pass membrane protein {ECO 0000269|PubMed 15138271, ECO 0000269|PubMed 15919996}. # TIGRFAMs TIGR00753 undec_PP_bacA # eggNOG COG1968 LUCA # eggNOG ENOG4105DWR Bacteria BLAST swissprot:UPPP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UPPP_ECOLI BioCyc ECOL316407:JW3029-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3029-MONOMER BioCyc EcoCyc:EG11665-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11665-MONOMER BioCyc MetaCyc:EG11665-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11665-MONOMER COG COG1968 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1968 DIP DIP-48044N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48044N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M401701200 http://dx.doi.org/10.1074/jbc.M401701200 DOI 10.1074/jbc.M412277200 http://dx.doi.org/10.1074/jbc.M412277200 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.1.27 http://www.genome.jp/dbget-bin/www_bget?EC:3.6.1.27 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L12966 http://www.ebi.ac.uk/ena/data/view/L12966 EMBL M12788 http://www.ebi.ac.uk/ena/data/view/M12788 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28379 http://www.ebi.ac.uk/ena/data/view/U28379 ENZYME 3.6.1.27 http://enzyme.expasy.org/EC/3.6.1.27 EchoBASE EB1616 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1616 EcoGene EG11665 http://www.ecogene.org/geneInfo.php?eg_id=EG11665 EnsemblBacteria AAC76093 http://www.ensemblgenomes.org/id/AAC76093 EnsemblBacteria AAC76093 http://www.ensemblgenomes.org/id/AAC76093 EnsemblBacteria BAE77108 http://www.ensemblgenomes.org/id/BAE77108 EnsemblBacteria BAE77108 http://www.ensemblgenomes.org/id/BAE77108 EnsemblBacteria BAE77108 http://www.ensemblgenomes.org/id/BAE77108 EnsemblBacteria b3057 http://www.ensemblgenomes.org/id/b3057 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0050380 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050380 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0009252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009252 GO_process GO:0016311 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016311 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 GeneID 947551 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947551 HAMAP MF_01006 http://hamap.expasy.org/unirule/MF_01006 HOGENOM HOG000218356 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218356&db=HOGENOM6 InParanoid P60932 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P60932 IntAct P60932 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P60932* IntEnz 3.6.1.27 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.1.27 InterPro IPR003824 http://www.ebi.ac.uk/interpro/entry/IPR003824 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3029 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3029 KEGG_Gene eco:b3057 http://www.genome.jp/dbget-bin/www_bget?eco:b3057 KEGG_Orthology KO:K06153 http://www.genome.jp/dbget-bin/www_bget?KO:K06153 KEGG_Pathway ko00550 http://www.genome.jp/kegg-bin/show_pathway?ko00550 KEGG_Reaction rn:R05627 http://www.genome.jp/dbget-bin/www_bget?rn:R05627 OMA KVFDIAI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KVFDIAI PSORT swissprot:UPPP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UPPP_ECOLI PSORT-B swissprot:UPPP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UPPP_ECOLI PSORT2 swissprot:UPPP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UPPP_ECOLI Pfam PF02673 http://pfam.xfam.org/family/PF02673 Phobius swissprot:UPPP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UPPP_ECOLI PhylomeDB P60932 http://phylomedb.org/?seqid=P60932 ProteinModelPortal P60932 http://www.proteinmodelportal.org/query/uniprot/P60932 PubMed 15138271 http://www.ncbi.nlm.nih.gov/pubmed/15138271 PubMed 15778224 http://www.ncbi.nlm.nih.gov/pubmed/15778224 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3009457 http://www.ncbi.nlm.nih.gov/pubmed/3009457 PubMed 8389741 http://www.ncbi.nlm.nih.gov/pubmed/8389741 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417529 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417529 RefSeq WP_001281927 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001281927 STRING 511145.b3057 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3057&targetmode=cogs STRING COG1968 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1968&targetmode=cogs TIGRFAMs TIGR00753 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00753 UniProtKB UPPP_ECOLI http://www.uniprot.org/uniprot/UPPP_ECOLI UniProtKB-AC P60932 http://www.uniprot.org/uniprot/P60932 charge swissprot:UPPP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UPPP_ECOLI eggNOG COG1968 http://eggnogapi.embl.de/nog_data/html/tree/COG1968 eggNOG ENOG4105DWR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DWR epestfind swissprot:UPPP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UPPP_ECOLI garnier swissprot:UPPP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UPPP_ECOLI helixturnhelix swissprot:UPPP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UPPP_ECOLI hmoment swissprot:UPPP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UPPP_ECOLI iep swissprot:UPPP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UPPP_ECOLI inforesidue swissprot:UPPP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UPPP_ECOLI octanol swissprot:UPPP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UPPP_ECOLI pepcoil swissprot:UPPP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UPPP_ECOLI pepdigest swissprot:UPPP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UPPP_ECOLI pepinfo swissprot:UPPP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UPPP_ECOLI pepnet swissprot:UPPP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UPPP_ECOLI pepstats swissprot:UPPP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UPPP_ECOLI pepwheel swissprot:UPPP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UPPP_ECOLI pepwindow swissprot:UPPP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UPPP_ECOLI sigcleave swissprot:UPPP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UPPP_ECOLI ## Database ID URL or Descriptions # AltName Acetyl-CoA acetoacetate CoA-transferase subunit beta # BioGrid 4262987 8 # CATALYTIC ACTIVITY ATOA_ECOLI Acyl-CoA + acetate = a fatty acid anion + acetyl-CoA. # EcoGene EG11670 atoA # GO_function GO:0008775 acetate CoA-transferase activity; IMP:EcoliWiki. # GO_process GO:0046459 short-chain fatty acid metabolic process; IEA:UniProtKB-UniPathway. # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0044281 small molecule metabolic process # INTERACTION ATOA_ECOLI P0AC02 bamD; NbExp=2; IntAct=EBI-1128061, EBI-1128087; # IntAct P76459 4 # InterPro IPR004164 CoA_transf_AS # InterPro IPR004165 CoA_trans_fam_I # InterPro IPR012791 3-oxoacid_CoA-transf_B # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00627 Aminobenzoate degradation # KEGG_Pathway ko00640 Propanoate metabolism # KEGG_Pathway ko00650 Butanoate metabolism # KEGG_Pathway ko02020 Two-component system # Organism ATOA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR13707 PTHR13707 # PATHWAY ATOA_ECOLI Lipid metabolism; short-chain fatty acid metabolism. # PATRIC 32119803 VBIEscCol129921_2311 # PDB 5DBN X-ray; 2.55 A; B/D/F/H=1-216 # PIR D64992 D64992 # PROSITE PS01274 COA_TRANSF_2 # Pfam PF01144 CoA_trans # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ATOA_ECOLI Acetate CoA-transferase subunit beta # RefSeq NP_416726 NC_000913.3 # RefSeq WP_000339065 NZ_LN832404.1 # SIMILARITY Belongs to the 3-oxoacid CoA-transferase subunit B family. {ECO 0000305}. # SMART SM00882 CoA_trans # SUBUNIT Heterodimer. {ECO 0000250}. # TIGRFAMs TIGR02428 pcaJ_scoB_fam # eggNOG COG2057 LUCA # eggNOG ENOG4107QNJ Bacteria BLAST swissprot:ATOA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ATOA_ECOLI BioCyc ECOL316407:JW2216-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2216-MONOMER BioCyc EcoCyc:ATOA-MONOMER http://biocyc.org/getid?id=EcoCyc:ATOA-MONOMER BioCyc MetaCyc:ATOA-MONOMER http://biocyc.org/getid?id=MetaCyc:ATOA-MONOMER COG COG2057 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2057 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.8.3.8 http://www.genome.jp/dbget-bin/www_bget?EC:2.8.3.8 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.8.3.8 http://enzyme.expasy.org/EC/2.8.3.8 EchoBASE EB1621 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1621 EcoGene EG11670 http://www.ecogene.org/geneInfo.php?eg_id=EG11670 EnsemblBacteria AAC75282 http://www.ensemblgenomes.org/id/AAC75282 EnsemblBacteria AAC75282 http://www.ensemblgenomes.org/id/AAC75282 EnsemblBacteria BAA16018 http://www.ensemblgenomes.org/id/BAA16018 EnsemblBacteria BAA16018 http://www.ensemblgenomes.org/id/BAA16018 EnsemblBacteria BAA16018 http://www.ensemblgenomes.org/id/BAA16018 EnsemblBacteria b2222 http://www.ensemblgenomes.org/id/b2222 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008775 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008775 GO_process GO:0046459 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046459 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 946719 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946719 HOGENOM HOG000221245 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000221245&db=HOGENOM6 InParanoid P76459 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76459 IntAct P76459 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76459* IntEnz 2.8.3.8 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.8.3.8 InterPro IPR004164 http://www.ebi.ac.uk/interpro/entry/IPR004164 InterPro IPR004165 http://www.ebi.ac.uk/interpro/entry/IPR004165 InterPro IPR012791 http://www.ebi.ac.uk/interpro/entry/IPR012791 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2216 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2216 KEGG_Gene eco:b2222 http://www.genome.jp/dbget-bin/www_bget?eco:b2222 KEGG_Orthology KO:K01035 http://www.genome.jp/dbget-bin/www_bget?KO:K01035 KEGG_Pathway ko00627 http://www.genome.jp/kegg-bin/show_pathway?ko00627 KEGG_Pathway ko00640 http://www.genome.jp/kegg-bin/show_pathway?ko00640 KEGG_Pathway ko00650 http://www.genome.jp/kegg-bin/show_pathway?ko00650 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 KEGG_Reaction rn:R01179 http://www.genome.jp/dbget-bin/www_bget?rn:R01179 KEGG_Reaction rn:R01359 http://www.genome.jp/dbget-bin/www_bget?rn:R01359 KEGG_Reaction rn:R07832 http://www.genome.jp/dbget-bin/www_bget?rn:R07832 OMA DDHYDPT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DDHYDPT PANTHER PTHR13707 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13707 PDB 5DBN http://www.ebi.ac.uk/pdbe-srv/view/entry/5DBN PDBsum 5DBN http://www.ebi.ac.uk/pdbsum/5DBN PROSITE PS01274 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01274 PSORT swissprot:ATOA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ATOA_ECOLI PSORT-B swissprot:ATOA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ATOA_ECOLI PSORT2 swissprot:ATOA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ATOA_ECOLI Pfam PF01144 http://pfam.xfam.org/family/PF01144 Phobius swissprot:ATOA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ATOA_ECOLI PhylomeDB P76459 http://phylomedb.org/?seqid=P76459 ProteinModelPortal P76459 http://www.proteinmodelportal.org/query/uniprot/P76459 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416726 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416726 RefSeq WP_000339065 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000339065 SMART SM00882 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00882 SMR P76459 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76459 STRING 511145.b2222 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2222&targetmode=cogs STRING COG2057 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2057&targetmode=cogs TIGRFAMs TIGR02428 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02428 UniProtKB ATOA_ECOLI http://www.uniprot.org/uniprot/ATOA_ECOLI UniProtKB-AC P76459 http://www.uniprot.org/uniprot/P76459 charge swissprot:ATOA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ATOA_ECOLI eggNOG COG2057 http://eggnogapi.embl.de/nog_data/html/tree/COG2057 eggNOG ENOG4107QNJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QNJ epestfind swissprot:ATOA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ATOA_ECOLI garnier swissprot:ATOA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ATOA_ECOLI helixturnhelix swissprot:ATOA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ATOA_ECOLI hmoment swissprot:ATOA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ATOA_ECOLI iep swissprot:ATOA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ATOA_ECOLI inforesidue swissprot:ATOA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ATOA_ECOLI octanol swissprot:ATOA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ATOA_ECOLI pepcoil swissprot:ATOA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ATOA_ECOLI pepdigest swissprot:ATOA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ATOA_ECOLI pepinfo swissprot:ATOA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ATOA_ECOLI pepnet swissprot:ATOA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ATOA_ECOLI pepstats swissprot:ATOA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ATOA_ECOLI pepwheel swissprot:ATOA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ATOA_ECOLI pepwindow swissprot:ATOA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ATOA_ECOLI sigcleave swissprot:ATOA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ATOA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260627 11 # EcoGene EG14379 ypjK # Organism YPJK_ECOLI Escherichia coli (strain K12) # PATRIC 32120661 VBIEscCol129921_2729 # PIR E65042 E65042 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YPJK_ECOLI Uncharacterized protein YpjK # RefSeq WP_001144029 NZ_LN832404.1 # RefSeq YP_026174 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA79804.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAA79804.1; Type=Frameshift; Positions=61; Evidence={ECO 0000305}; # SIMILARITY To E.coli YkfL. {ECO 0000305}. BLAST swissprot:YPJK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YPJK_ECOLI BioCyc ECOL316407:JW5888-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5888-MONOMER BioCyc EcoCyc:G7370-MONOMER http://biocyc.org/getid?id=EcoCyc:G7370-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36840 http://www.ebi.ac.uk/ena/data/view/U36840 EchoBASE EB4122 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4122 EcoGene EG14379 http://www.ecogene.org/geneInfo.php?eg_id=EG14379 EnsemblBacteria AAC75683 http://www.ensemblgenomes.org/id/AAC75683 EnsemblBacteria AAC75683 http://www.ensemblgenomes.org/id/AAC75683 EnsemblBacteria BAE76770 http://www.ensemblgenomes.org/id/BAE76770 EnsemblBacteria BAE76770 http://www.ensemblgenomes.org/id/BAE76770 EnsemblBacteria BAE76770 http://www.ensemblgenomes.org/id/BAE76770 EnsemblBacteria b2635 http://www.ensemblgenomes.org/id/b2635 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 2847710 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2847710 HOGENOM HOG000054867 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000054867&db=HOGENOM6 KEGG_Gene ecj:JW5888 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5888 KEGG_Gene eco:b2635 http://www.genome.jp/dbget-bin/www_bget?eco:b2635 OMA FAKVLRW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FAKVLRW PSORT swissprot:YPJK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YPJK_ECOLI PSORT-B swissprot:YPJK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YPJK_ECOLI PSORT2 swissprot:YPJK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YPJK_ECOLI Phobius swissprot:YPJK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YPJK_ECOLI ProteinModelPortal P52134 http://www.proteinmodelportal.org/query/uniprot/P52134 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001144029 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001144029 RefSeq YP_026174 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026174 STRING 511145.b2635 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2635&targetmode=cogs UniProtKB YPJK_ECOLI http://www.uniprot.org/uniprot/YPJK_ECOLI UniProtKB-AC P52134 http://www.uniprot.org/uniprot/P52134 charge swissprot:YPJK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YPJK_ECOLI epestfind swissprot:YPJK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YPJK_ECOLI garnier swissprot:YPJK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YPJK_ECOLI helixturnhelix swissprot:YPJK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YPJK_ECOLI hmoment swissprot:YPJK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YPJK_ECOLI iep swissprot:YPJK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YPJK_ECOLI inforesidue swissprot:YPJK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YPJK_ECOLI octanol swissprot:YPJK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YPJK_ECOLI pepcoil swissprot:YPJK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YPJK_ECOLI pepdigest swissprot:YPJK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YPJK_ECOLI pepinfo swissprot:YPJK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YPJK_ECOLI pepnet swissprot:YPJK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YPJK_ECOLI pepstats swissprot:YPJK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YPJK_ECOLI pepwheel swissprot:YPJK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YPJK_ECOLI pepwindow swissprot:YPJK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YPJK_ECOLI sigcleave swissprot:YPJK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YPJK_ECOLI ## Database ID URL or Descriptions # InterPro IPR009253 DUF905 # Organism YUBL1_ECOLI Escherichia coli (strain K12) # Pfam PF06006 DUF905 # ProDom PD028015 DUF905_proteobac # RecName YUBL1_ECOLI UPF0401 protein YubL # RefSeq NP_061440 NC_002483.1 # RefSeq WP_001327110 NC_002483.1 # SEQUENCE CAUTION Sequence=AAD47188.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the UPF0401 family. {ECO 0000305}. BLAST swissprot:YUBL1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YUBL1_ECOLI DOI 10.1006/plas.1999.1390 http://dx.doi.org/10.1006/plas.1999.1390 EMBL AF106329 http://www.ebi.ac.uk/ena/data/view/AF106329 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1263591 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263591 InterPro IPR009253 http://www.ebi.ac.uk/interpro/entry/IPR009253 OMA RMSEYFR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RMSEYFR PSORT swissprot:YUBL1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YUBL1_ECOLI PSORT-B swissprot:YUBL1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YUBL1_ECOLI PSORT2 swissprot:YUBL1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YUBL1_ECOLI Pfam PF06006 http://pfam.xfam.org/family/PF06006 Phobius swissprot:YUBL1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YUBL1_ECOLI PhylomeDB Q9JMR3 http://phylomedb.org/?seqid=Q9JMR3 ProteinModelPortal Q9JMR3 http://www.proteinmodelportal.org/query/uniprot/Q9JMR3 PubMed 10366527 http://www.ncbi.nlm.nih.gov/pubmed/10366527 RefSeq NP_061440 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061440 RefSeq WP_001327110 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001327110 SMR Q9JMR3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9JMR3 UniProtKB YUBL1_ECOLI http://www.uniprot.org/uniprot/YUBL1_ECOLI UniProtKB-AC Q9JMR3 http://www.uniprot.org/uniprot/Q9JMR3 charge swissprot:YUBL1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YUBL1_ECOLI epestfind swissprot:YUBL1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YUBL1_ECOLI garnier swissprot:YUBL1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YUBL1_ECOLI helixturnhelix swissprot:YUBL1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YUBL1_ECOLI hmoment swissprot:YUBL1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YUBL1_ECOLI iep swissprot:YUBL1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YUBL1_ECOLI inforesidue swissprot:YUBL1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YUBL1_ECOLI octanol swissprot:YUBL1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YUBL1_ECOLI pepcoil swissprot:YUBL1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YUBL1_ECOLI pepdigest swissprot:YUBL1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YUBL1_ECOLI pepinfo swissprot:YUBL1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YUBL1_ECOLI pepnet swissprot:YUBL1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YUBL1_ECOLI pepstats swissprot:YUBL1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YUBL1_ECOLI pepwheel swissprot:YUBL1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YUBL1_ECOLI pepwindow swissprot:YUBL1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YUBL1_ECOLI sigcleave swissprot:YUBL1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YUBL1_ECOLI ## Database ID URL or Descriptions # BioGrid 4260584 40 # CDD cd00207 fer2 # COFACTOR Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI 49601; Note=Binds 1 [2Fe-2S] cluster.; # EcoGene EG11328 fdx # FUNCTION FER_ECOLI Ferredoxin are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. Although the function of this ferredoxin is unknown it is probable that it has a role as a cellular electron transfer protein. Involved in the in vivo assembly of the Fe-S clusters in a wide variety of iron- sulfur proteins. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0009055 electron carrier activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051537 2 iron, 2 sulfur cluster binding; IDA:EcoCyc. # GO_process GO:0016226 iron-sulfur cluster assembly; IMP:EcoCyc. # GO_process GO:0055114 oxidation-reduction process; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.10.20.30 -; 1. # INTERACTION FER_ECOLI P0AAC8 iscA; NbExp=4; IntAct=EBI-767037, EBI-767026; # IntAct P0A9R4 13 # InterPro IPR001041 2Fe-2S_ferredoxin-type # InterPro IPR001055 Adrenodoxin # InterPro IPR011536 Fdx_isc # InterPro IPR012675 Beta-grasp_dom # InterPro IPR018298 Adrenodoxin_Fe-S_BS # Organism FER_ECOLI Escherichia coli (strain K12) # PATRIC 32120445 VBIEscCol129921_2625 # PDB 1I7H X-ray; 1.70 A; A/B/C=1-111 # PIR JC1110 JC1110 # PRINTS PR00355 ADRENODOXIN # PROSITE PS00814 ADX # PROSITE PS51085 2FE2S_FER_2 # Pfam PF00111 Fer2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FER_ECOLI 2Fe-2S ferredoxin # RefSeq NP_417020 NC_000913.3 # RefSeq WP_001124469 NZ_LN832404.1 # SIMILARITY Belongs to the adrenodoxin/putidaredoxin family. {ECO 0000305}. # SIMILARITY Contains 1 2Fe-2S ferredoxin-type domain. {ECO:0000255|PROSITE-ProRule PRU00465}. # SUPFAM SSF54292 SSF54292 # TIGRFAMs TIGR02007 fdx_isc # eggNOG COG0633 LUCA # eggNOG ENOG4108ZIT Bacteria BLAST swissprot:FER_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FER_ECOLI BioCyc ECOL316407:JW2509-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2509-MONOMER BioCyc EcoCyc:FERREDOXIN-MONOMER http://biocyc.org/getid?id=EcoCyc:FERREDOXIN-MONOMER BioCyc MetaCyc:FERREDOXIN-MONOMER http://biocyc.org/getid?id=MetaCyc:FERREDOXIN-MONOMER COG COG0633 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0633 DIP DIP-48512N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48512N DOI 10.1021/bi010544t http://dx.doi.org/10.1021/bi010544t DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/oxfordjournals.jbchem.a022409 http://dx.doi.org/10.1093/oxfordjournals.jbchem.a022409 DOI 10.1111/j.1432-1033.1974.tb03893.x http://dx.doi.org/10.1111/j.1432-1033.1974.tb03893.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M88654 http://www.ebi.ac.uk/ena/data/view/M88654 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U01827 http://www.ebi.ac.uk/ena/data/view/U01827 EMBL U05338 http://www.ebi.ac.uk/ena/data/view/U05338 EchoBASE EB1304 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1304 EcoGene EG11328 http://www.ecogene.org/geneInfo.php?eg_id=EG11328 EnsemblBacteria AAC75578 http://www.ensemblgenomes.org/id/AAC75578 EnsemblBacteria AAC75578 http://www.ensemblgenomes.org/id/AAC75578 EnsemblBacteria BAA16415 http://www.ensemblgenomes.org/id/BAA16415 EnsemblBacteria BAA16415 http://www.ensemblgenomes.org/id/BAA16415 EnsemblBacteria BAA16415 http://www.ensemblgenomes.org/id/BAA16415 EnsemblBacteria b2525 http://www.ensemblgenomes.org/id/b2525 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051537 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051537 GO_process GO:0016226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016226 GO_process GO:0055114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.10.20.30 http://www.cathdb.info/version/latest/superfamily/3.10.20.30 GeneID 947160 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947160 HOGENOM HOG000244519 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000244519&db=HOGENOM6 InParanoid P0A9R4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9R4 IntAct P0A9R4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9R4* InterPro IPR001041 http://www.ebi.ac.uk/interpro/entry/IPR001041 InterPro IPR001055 http://www.ebi.ac.uk/interpro/entry/IPR001055 InterPro IPR011536 http://www.ebi.ac.uk/interpro/entry/IPR011536 InterPro IPR012675 http://www.ebi.ac.uk/interpro/entry/IPR012675 InterPro IPR018298 http://www.ebi.ac.uk/interpro/entry/IPR018298 KEGG_Gene ecj:JW2509 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2509 KEGG_Gene eco:b2525 http://www.genome.jp/dbget-bin/www_bget?eco:b2525 KEGG_Orthology KO:K04755 http://www.genome.jp/dbget-bin/www_bget?KO:K04755 OMA SACGGVC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SACGGVC PDB 1I7H http://www.ebi.ac.uk/pdbe-srv/view/entry/1I7H PDBsum 1I7H http://www.ebi.ac.uk/pdbsum/1I7H PRINTS PR00355 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00355 PROSITE PS00814 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00814 PROSITE PS51085 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51085 PSORT swissprot:FER_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FER_ECOLI PSORT-B swissprot:FER_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FER_ECOLI PSORT2 swissprot:FER_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FER_ECOLI Pfam PF00111 http://pfam.xfam.org/family/PF00111 Phobius swissprot:FER_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FER_ECOLI PhylomeDB P0A9R4 http://phylomedb.org/?seqid=P0A9R4 ProteinModelPortal P0A9R4 http://www.proteinmodelportal.org/query/uniprot/P0A9R4 PubMed 10393315 http://www.ncbi.nlm.nih.gov/pubmed/10393315 PubMed 11551196 http://www.ncbi.nlm.nih.gov/pubmed/11551196 PubMed 1317854 http://www.ncbi.nlm.nih.gov/pubmed/1317854 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 4375562 http://www.ncbi.nlm.nih.gov/pubmed/4375562 PubMed 8300516 http://www.ncbi.nlm.nih.gov/pubmed/8300516 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417020 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417020 RefSeq WP_001124469 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001124469 SMR P0A9R4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9R4 STRING 511145.b2525 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2525&targetmode=cogs STRING COG0633 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0633&targetmode=cogs SUPFAM SSF54292 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54292 TIGRFAMs TIGR02007 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02007 UniProtKB FER_ECOLI http://www.uniprot.org/uniprot/FER_ECOLI UniProtKB-AC P0A9R4 http://www.uniprot.org/uniprot/P0A9R4 charge swissprot:FER_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FER_ECOLI eggNOG COG0633 http://eggnogapi.embl.de/nog_data/html/tree/COG0633 eggNOG ENOG4108ZIT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZIT epestfind swissprot:FER_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FER_ECOLI garnier swissprot:FER_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FER_ECOLI helixturnhelix swissprot:FER_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FER_ECOLI hmoment swissprot:FER_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FER_ECOLI iep swissprot:FER_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FER_ECOLI inforesidue swissprot:FER_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FER_ECOLI octanol swissprot:FER_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FER_ECOLI pepcoil swissprot:FER_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FER_ECOLI pepdigest swissprot:FER_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FER_ECOLI pepinfo swissprot:FER_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FER_ECOLI pepnet swissprot:FER_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FER_ECOLI pepstats swissprot:FER_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FER_ECOLI pepwheel swissprot:FER_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FER_ECOLI pepwindow swissprot:FER_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FER_ECOLI sigcleave swissprot:FER_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FER_ECOLI ## Database ID URL or Descriptions # BioGrid 4260158 10 # EcoGene EG12174 ydaG # INDUCTION Constitutively expressed (at protein level). {ECO:0000269|PubMed 19121005}. # IntAct P76061 4 # InterPro IPR009060 UBA-like # Organism YDAG_ECOLI Escherichia coli (strain K12) # PATRIC 32117990 VBIEscCol129921_1415 # PIR F64885 F64885 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDAG_ECOLI Uncharacterized protein YdaG # RefSeq NP_415873 NC_000913.3 # SUPFAM SSF46934 SSF46934 BLAST swissprot:YDAG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDAG_ECOLI BioCyc ECOL316407:JW5210-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5210-MONOMER BioCyc EcoCyc:G6679-MONOMER http://biocyc.org/getid?id=EcoCyc:G6679-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2008.06495.x http://dx.doi.org/10.1111/j.1365-2958.2008.06495.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2092 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2092 EcoGene EG12174 http://www.ecogene.org/geneInfo.php?eg_id=EG12174 EnsemblBacteria AAC74437 http://www.ensemblgenomes.org/id/AAC74437 EnsemblBacteria AAC74437 http://www.ensemblgenomes.org/id/AAC74437 EnsemblBacteria BAE76410 http://www.ensemblgenomes.org/id/BAE76410 EnsemblBacteria BAE76410 http://www.ensemblgenomes.org/id/BAE76410 EnsemblBacteria BAE76410 http://www.ensemblgenomes.org/id/BAE76410 EnsemblBacteria b1355 http://www.ensemblgenomes.org/id/b1355 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945907 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945907 HOGENOM HOG000054870 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000054870&db=HOGENOM6 IntAct P76061 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76061* InterPro IPR009060 http://www.ebi.ac.uk/interpro/entry/IPR009060 KEGG_Gene ecj:JW5210 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5210 KEGG_Gene eco:b1355 http://www.genome.jp/dbget-bin/www_bget?eco:b1355 PSORT swissprot:YDAG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDAG_ECOLI PSORT-B swissprot:YDAG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDAG_ECOLI PSORT2 swissprot:YDAG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDAG_ECOLI Phobius swissprot:YDAG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDAG_ECOLI ProteinModelPortal P76061 http://www.proteinmodelportal.org/query/uniprot/P76061 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19121005 http://www.ncbi.nlm.nih.gov/pubmed/19121005 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415873 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415873 STRING 511145.b1355 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1355&targetmode=cogs SUPFAM SSF46934 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46934 UniProtKB YDAG_ECOLI http://www.uniprot.org/uniprot/YDAG_ECOLI UniProtKB-AC P76061 http://www.uniprot.org/uniprot/P76061 charge swissprot:YDAG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDAG_ECOLI epestfind swissprot:YDAG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDAG_ECOLI garnier swissprot:YDAG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDAG_ECOLI helixturnhelix swissprot:YDAG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDAG_ECOLI hmoment swissprot:YDAG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDAG_ECOLI iep swissprot:YDAG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDAG_ECOLI inforesidue swissprot:YDAG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDAG_ECOLI octanol swissprot:YDAG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDAG_ECOLI pepcoil swissprot:YDAG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDAG_ECOLI pepdigest swissprot:YDAG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDAG_ECOLI pepinfo swissprot:YDAG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDAG_ECOLI pepnet swissprot:YDAG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDAG_ECOLI pepstats swissprot:YDAG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDAG_ECOLI pepwheel swissprot:YDAG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDAG_ECOLI pepwindow swissprot:YDAG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDAG_ECOLI sigcleave swissprot:YDAG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDAG_ECOLI ## Database ID URL or Descriptions # BioGrid 4262547 13 # EcoGene EG12280 yiaL # Gene3D 2.60.120.370 -; 1. # InterPro IPR004375 YhcH/YjgK/YiaL # Organism YIAL_ECOLI Escherichia coli (strain K12) # PATRIC 32122628 VBIEscCol129921_3691 # PIR S47797 S47797 # Pfam PF04074 DUF386 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIAL_ECOLI Protein YiaL # RefSeq NP_418033 NC_000913.3 # RefSeq WP_000576079 NZ_LN832404.1 # SIMILARITY Belongs to the TabA/YhcH/YiaL family. {ECO 0000305}. # TIGRFAMs TIGR00022 TIGR00022 # eggNOG COG2731 LUCA # eggNOG ENOG4108R66 Bacteria BLAST swissprot:YIAL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIAL_ECOLI BioCyc ECOL316407:JW3548-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3548-MONOMER BioCyc EcoCyc:EG12280-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12280-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2188 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2188 EcoGene EG12280 http://www.ecogene.org/geneInfo.php?eg_id=EG12280 EnsemblBacteria AAC76600 http://www.ensemblgenomes.org/id/AAC76600 EnsemblBacteria AAC76600 http://www.ensemblgenomes.org/id/AAC76600 EnsemblBacteria BAE77717 http://www.ensemblgenomes.org/id/BAE77717 EnsemblBacteria BAE77717 http://www.ensemblgenomes.org/id/BAE77717 EnsemblBacteria BAE77717 http://www.ensemblgenomes.org/id/BAE77717 EnsemblBacteria b3576 http://www.ensemblgenomes.org/id/b3576 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 2.60.120.370 http://www.cathdb.info/version/latest/superfamily/2.60.120.370 GeneID 948094 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948094 HOGENOM HOG000282946 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000282946&db=HOGENOM6 InParanoid P37673 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37673 InterPro IPR004375 http://www.ebi.ac.uk/interpro/entry/IPR004375 KEGG_Gene ecj:JW3548 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3548 KEGG_Gene eco:b3576 http://www.genome.jp/dbget-bin/www_bget?eco:b3576 OMA RDIIFYQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RDIIFYQ PSORT swissprot:YIAL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIAL_ECOLI PSORT-B swissprot:YIAL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIAL_ECOLI PSORT2 swissprot:YIAL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIAL_ECOLI Pfam PF04074 http://pfam.xfam.org/family/PF04074 Phobius swissprot:YIAL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIAL_ECOLI PhylomeDB P37673 http://phylomedb.org/?seqid=P37673 ProteinModelPortal P37673 http://www.proteinmodelportal.org/query/uniprot/P37673 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418033 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418033 RefSeq WP_000576079 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000576079 SMR P37673 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37673 STRING 511145.b3576 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3576&targetmode=cogs TIGRFAMs TIGR00022 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00022 UniProtKB YIAL_ECOLI http://www.uniprot.org/uniprot/YIAL_ECOLI UniProtKB-AC P37673 http://www.uniprot.org/uniprot/P37673 charge swissprot:YIAL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIAL_ECOLI eggNOG COG2731 http://eggnogapi.embl.de/nog_data/html/tree/COG2731 eggNOG ENOG4108R66 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108R66 epestfind swissprot:YIAL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIAL_ECOLI garnier swissprot:YIAL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIAL_ECOLI helixturnhelix swissprot:YIAL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIAL_ECOLI hmoment swissprot:YIAL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIAL_ECOLI iep swissprot:YIAL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIAL_ECOLI inforesidue swissprot:YIAL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIAL_ECOLI octanol swissprot:YIAL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIAL_ECOLI pepcoil swissprot:YIAL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIAL_ECOLI pepdigest swissprot:YIAL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIAL_ECOLI pepinfo swissprot:YIAL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIAL_ECOLI pepnet swissprot:YIAL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIAL_ECOLI pepstats swissprot:YIAL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIAL_ECOLI pepwheel swissprot:YIAL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIAL_ECOLI pepwindow swissprot:YIAL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIAL_ECOLI sigcleave swissprot:YIAL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIAL_ECOLI ## Database ID URL or Descriptions # BioGrid 4262338 148 # EcoGene EG10830 recJ # FUNCTION RECJ_ECOLI Single-stranded-DNA-specific exonuclease. Required for many types of recombinational events, although the stringency of the requirement for RecJ appears to vary with the type of recombinational event monitored and the other recombination gene products which are available. {ECO 0000269|PubMed 2649886}. # GO_function GO:0003676 nucleic acid binding; IEA:InterPro. # GO_function GO:0008409 5'-3' exonuclease activity; IEA:InterPro. # GO_process GO:0006281 DNA repair; IEA:InterPro. # GO_process GO:0006310 DNA recombination; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0004518 nuclease activity # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # IntAct P21893 24 # InterPro IPR001667 DDH_dom # InterPro IPR003156 DHHA1_dom # InterPro IPR004610 RecJ # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko03410 Base excision repair # KEGG_Pathway ko03430 Mismatch repair # KEGG_Pathway ko03440 Homologous recombination # Organism RECJ_ECOLI Escherichia coli (strain K12) # PATRIC 32121196 VBIEscCol129921_2986 # PIR D65073 D65073 # Pfam PF01368 DHH # Pfam PF02272 DHHA1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RECJ_ECOLI Single-stranded-DNA-specific exonuclease RecJ # RefSeq NP_417368 NC_000913.3 # RefSeq WP_000813200 NZ_LN832404.1 # SIMILARITY Belongs to the RecJ family. {ECO 0000305}. # TIGRFAMs TIGR00644 recJ # eggNOG COG0608 LUCA # eggNOG ENOG4105C2R Bacteria BLAST swissprot:RECJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RECJ_ECOLI BioCyc ECOL316407:JW2860-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2860-MONOMER BioCyc EcoCyc:EG10830-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10830-MONOMER COG COG0608 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0608 DIP DIP-10654N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10654N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.86.8.2627 http://dx.doi.org/10.1073/pnas.86.8.2627 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M54884 http://www.ebi.ac.uk/ena/data/view/M54884 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 ENZYME 3.1.-.- http://enzyme.expasy.org/EC/3.1.-.- EchoBASE EB0823 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0823 EcoGene EG10830 http://www.ecogene.org/geneInfo.php?eg_id=EG10830 EnsemblBacteria AAC75930 http://www.ensemblgenomes.org/id/AAC75930 EnsemblBacteria AAC75930 http://www.ensemblgenomes.org/id/AAC75930 EnsemblBacteria BAE76957 http://www.ensemblgenomes.org/id/BAE76957 EnsemblBacteria BAE76957 http://www.ensemblgenomes.org/id/BAE76957 EnsemblBacteria BAE76957 http://www.ensemblgenomes.org/id/BAE76957 EnsemblBacteria b2892 http://www.ensemblgenomes.org/id/b2892 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003676 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003676 GO_function GO:0008409 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008409 GO_process GO:0006281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006281 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 947367 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947367 HOGENOM HOG000018414 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000018414&db=HOGENOM6 InParanoid P21893 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P21893 IntAct P21893 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P21893* IntEnz 3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1 InterPro IPR001667 http://www.ebi.ac.uk/interpro/entry/IPR001667 InterPro IPR003156 http://www.ebi.ac.uk/interpro/entry/IPR003156 InterPro IPR004610 http://www.ebi.ac.uk/interpro/entry/IPR004610 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW2860 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2860 KEGG_Gene eco:b2892 http://www.genome.jp/dbget-bin/www_bget?eco:b2892 KEGG_Orthology KO:K07462 http://www.genome.jp/dbget-bin/www_bget?KO:K07462 KEGG_Pathway ko03410 http://www.genome.jp/kegg-bin/show_pathway?ko03410 KEGG_Pathway ko03430 http://www.genome.jp/kegg-bin/show_pathway?ko03430 KEGG_Pathway ko03440 http://www.genome.jp/kegg-bin/show_pathway?ko03440 MINT MINT-1223840 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1223840 OMA NRFDYGY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NRFDYGY PSORT swissprot:RECJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RECJ_ECOLI PSORT-B swissprot:RECJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RECJ_ECOLI PSORT2 swissprot:RECJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RECJ_ECOLI Pfam PF01368 http://pfam.xfam.org/family/PF01368 Pfam PF02272 http://pfam.xfam.org/family/PF02272 Phobius swissprot:RECJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RECJ_ECOLI PhylomeDB P21893 http://phylomedb.org/?seqid=P21893 ProteinModelPortal P21893 http://www.proteinmodelportal.org/query/uniprot/P21893 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1987126 http://www.ncbi.nlm.nih.gov/pubmed/1987126 PubMed 2649886 http://www.ncbi.nlm.nih.gov/pubmed/2649886 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417368 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417368 RefSeq WP_000813200 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000813200 SMR P21893 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P21893 STRING 511145.b2892 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2892&targetmode=cogs STRING COG0608 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0608&targetmode=cogs TIGRFAMs TIGR00644 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00644 UniProtKB RECJ_ECOLI http://www.uniprot.org/uniprot/RECJ_ECOLI UniProtKB-AC P21893 http://www.uniprot.org/uniprot/P21893 charge swissprot:RECJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RECJ_ECOLI eggNOG COG0608 http://eggnogapi.embl.de/nog_data/html/tree/COG0608 eggNOG ENOG4105C2R http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C2R epestfind swissprot:RECJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RECJ_ECOLI garnier swissprot:RECJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RECJ_ECOLI helixturnhelix swissprot:RECJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RECJ_ECOLI hmoment swissprot:RECJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RECJ_ECOLI iep swissprot:RECJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RECJ_ECOLI inforesidue swissprot:RECJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RECJ_ECOLI octanol swissprot:RECJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RECJ_ECOLI pepcoil swissprot:RECJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RECJ_ECOLI pepdigest swissprot:RECJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RECJ_ECOLI pepinfo swissprot:RECJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RECJ_ECOLI pepnet swissprot:RECJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RECJ_ECOLI pepstats swissprot:RECJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RECJ_ECOLI pepwheel swissprot:RECJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RECJ_ECOLI pepwindow swissprot:RECJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RECJ_ECOLI sigcleave swissprot:RECJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RECJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4262316 126 # EcoGene EG13046 ygeP # IntAct Q46796 2 # Organism YGEP_ECOLI Escherichia coli (strain K12) # PIR G65069 G65069 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGEP_ECOLI Uncharacterized protein YgeP BLAST swissprot:YGEP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGEP_ECOLI BioCyc ECOL316407:JW2831-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2831-MONOMER BioCyc EcoCyc:G7482-MONOMER http://biocyc.org/getid?id=EcoCyc:G7482-MONOMER DIP DIP-12154N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12154N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 EchoBASE EB2858 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2858 EcoGene EG13046 http://www.ecogene.org/geneInfo.php?eg_id=EG13046 EnsemblBacteria BAE76929 http://www.ensemblgenomes.org/id/BAE76929 EnsemblBacteria BAE76929 http://www.ensemblgenomes.org/id/BAE76929 EnsemblBacteria BAE76929 http://www.ensemblgenomes.org/id/BAE76929 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv IntAct Q46796 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46796* KEGG_Gene ecj:JW2831 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2831 PSORT swissprot:YGEP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGEP_ECOLI PSORT-B swissprot:YGEP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGEP_ECOLI PSORT2 swissprot:YGEP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGEP_ECOLI Phobius swissprot:YGEP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGEP_ECOLI ProteinModelPortal Q46796 http://www.proteinmodelportal.org/query/uniprot/Q46796 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 STRING 316407.85675676 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85675676&targetmode=cogs UniProtKB YGEP_ECOLI http://www.uniprot.org/uniprot/YGEP_ECOLI UniProtKB-AC Q46796 http://www.uniprot.org/uniprot/Q46796 charge swissprot:YGEP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGEP_ECOLI epestfind swissprot:YGEP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGEP_ECOLI garnier swissprot:YGEP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGEP_ECOLI helixturnhelix swissprot:YGEP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGEP_ECOLI hmoment swissprot:YGEP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGEP_ECOLI iep swissprot:YGEP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGEP_ECOLI inforesidue swissprot:YGEP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGEP_ECOLI octanol swissprot:YGEP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGEP_ECOLI pepcoil swissprot:YGEP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGEP_ECOLI pepdigest swissprot:YGEP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGEP_ECOLI pepinfo swissprot:YGEP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGEP_ECOLI pepnet swissprot:YGEP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGEP_ECOLI pepstats swissprot:YGEP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGEP_ECOLI pepwheel swissprot:YGEP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGEP_ECOLI pepwindow swissprot:YGEP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGEP_ECOLI sigcleave swissprot:YGEP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGEP_ECOLI ## Database ID URL or Descriptions # BioGrid 4261668 82 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG11766 yibJ # GO_process GO:0097264 self proteolysis; IEA:InterPro. # GOslim_process GO:0008150 biological_process # InterPro IPR001826 RHS # InterPro IPR022385 Rhs_assc_core # Organism YIBJ_ECOLI Escherichia coli (strain K12) # PATRIC 48666878 VBIEscCol107702_3707 # PIR E65159 E65159 # PRINTS PR00394 RHSPROTEIN # Pfam PF03527 RHS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIBJ_ECOLI Putative uncharacterized protein YibJ # SIMILARITY Belongs to the RHS family. {ECO 0000305}. # TIGRFAMs TIGR03696 Rhs_assc_core # eggNOG COG3209 LUCA BLAST swissprot:YIBJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIBJ_ECOLI BioCyc ECOL316407:JW5647-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5647-MONOMER BioCyc EcoCyc:EG11766-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11766-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19044 http://www.ebi.ac.uk/ena/data/view/L19044 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1716 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1716 EcoGene EG11766 http://www.ecogene.org/geneInfo.php?eg_id=EG11766 EnsemblBacteria BAE77698 http://www.ensemblgenomes.org/id/BAE77698 EnsemblBacteria BAE77698 http://www.ensemblgenomes.org/id/BAE77698 EnsemblBacteria BAE77698 http://www.ensemblgenomes.org/id/BAE77698 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0097264 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097264 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 HOGENOM HOG000009634 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009634&db=HOGENOM6 InterPro IPR001826 http://www.ebi.ac.uk/interpro/entry/IPR001826 InterPro IPR022385 http://www.ebi.ac.uk/interpro/entry/IPR022385 KEGG_Gene ecj:JW5647 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5647 OMA QGRYISQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QGRYISQ PRINTS PR00394 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00394 PSORT swissprot:YIBJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIBJ_ECOLI PSORT-B swissprot:YIBJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIBJ_ECOLI PSORT2 swissprot:YIBJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIBJ_ECOLI Pfam PF03527 http://pfam.xfam.org/family/PF03527 Phobius swissprot:YIBJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIBJ_ECOLI PhylomeDB P32109 http://phylomedb.org/?seqid=P32109 ProteinModelPortal P32109 http://www.proteinmodelportal.org/query/uniprot/P32109 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 8387990 http://www.ncbi.nlm.nih.gov/pubmed/8387990 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SMR P32109 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32109 STRING 316407.85676448 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85676448&targetmode=cogs TIGRFAMs TIGR03696 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03696 UniProtKB YIBJ_ECOLI http://www.uniprot.org/uniprot/YIBJ_ECOLI UniProtKB-AC P32109 http://www.uniprot.org/uniprot/P32109 charge swissprot:YIBJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIBJ_ECOLI eggNOG COG3209 http://eggnogapi.embl.de/nog_data/html/tree/COG3209 epestfind swissprot:YIBJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIBJ_ECOLI garnier swissprot:YIBJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIBJ_ECOLI helixturnhelix swissprot:YIBJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIBJ_ECOLI hmoment swissprot:YIBJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIBJ_ECOLI iep swissprot:YIBJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIBJ_ECOLI inforesidue swissprot:YIBJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIBJ_ECOLI octanol swissprot:YIBJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIBJ_ECOLI pepcoil swissprot:YIBJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIBJ_ECOLI pepdigest swissprot:YIBJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIBJ_ECOLI pepinfo swissprot:YIBJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIBJ_ECOLI pepnet swissprot:YIBJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIBJ_ECOLI pepstats swissprot:YIBJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIBJ_ECOLI pepwheel swissprot:YIBJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIBJ_ECOLI pepwindow swissprot:YIBJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIBJ_ECOLI sigcleave swissprot:YIBJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIBJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4260270 170 # CDD cd06174 MFS # EcoGene EG13950 ydhP # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0055085 transmembrane transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0055085 transmembrane transport # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # KEGG_Brite ko02000 Transporters # Organism YDHP_ECOLI Escherichia coli (strain K12) # PATRIC 32118618 VBIEscCol129921_1729 # PIR C64923 C64923 # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDHP_ECOLI Inner membrane transport protein YdhP # RefSeq NP_416174 NC_000913.3 # RefSeq WP_000701040 NZ_LN832404.1 # SIMILARITY Belongs to the major facilitator superfamily. {ECO 0000305}. # SUBCELLULAR LOCATION YDHP_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.2.65 the major facilitator superfamily (mfs) # eggNOG COG2814 LUCA # eggNOG ENOG4105F27 Bacteria BLAST swissprot:YDHP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDHP_ECOLI BioCyc ECOL316407:JW1649-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1649-MONOMER BioCyc EcoCyc:B1657-MONOMER http://biocyc.org/getid?id=EcoCyc:B1657-MONOMER COG COG2814 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2814 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3708 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3708 EcoGene EG13950 http://www.ecogene.org/geneInfo.php?eg_id=EG13950 EnsemblBacteria AAC74729 http://www.ensemblgenomes.org/id/AAC74729 EnsemblBacteria AAC74729 http://www.ensemblgenomes.org/id/AAC74729 EnsemblBacteria BAA15423 http://www.ensemblgenomes.org/id/BAA15423 EnsemblBacteria BAA15423 http://www.ensemblgenomes.org/id/BAA15423 EnsemblBacteria BAA15423 http://www.ensemblgenomes.org/id/BAA15423 EnsemblBacteria b1657 http://www.ensemblgenomes.org/id/b1657 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 947340 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947340 HOGENOM HOG000136927 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000136927&db=HOGENOM6 InParanoid P77389 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77389 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1649 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1649 KEGG_Gene eco:b1657 http://www.genome.jp/dbget-bin/www_bget?eco:b1657 KEGG_Orthology KO:K08156 http://www.genome.jp/dbget-bin/www_bget?KO:K08156 OMA RTPGRIN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RTPGRIN PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:YDHP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDHP_ECOLI PSORT-B swissprot:YDHP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDHP_ECOLI PSORT2 swissprot:YDHP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDHP_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:YDHP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDHP_ECOLI PhylomeDB P77389 http://phylomedb.org/?seqid=P77389 ProteinModelPortal P77389 http://www.proteinmodelportal.org/query/uniprot/P77389 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416174 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416174 RefSeq WP_000701040 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000701040 STRING 511145.b1657 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1657&targetmode=cogs STRING COG2814 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2814&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.2.65 http://www.tcdb.org/search/result.php?tc=2.A.1.2.65 UniProtKB YDHP_ECOLI http://www.uniprot.org/uniprot/YDHP_ECOLI UniProtKB-AC P77389 http://www.uniprot.org/uniprot/P77389 charge swissprot:YDHP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDHP_ECOLI eggNOG COG2814 http://eggnogapi.embl.de/nog_data/html/tree/COG2814 eggNOG ENOG4105F27 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F27 epestfind swissprot:YDHP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDHP_ECOLI garnier swissprot:YDHP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDHP_ECOLI helixturnhelix swissprot:YDHP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDHP_ECOLI hmoment swissprot:YDHP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDHP_ECOLI iep swissprot:YDHP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDHP_ECOLI inforesidue swissprot:YDHP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDHP_ECOLI octanol swissprot:YDHP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDHP_ECOLI pepcoil swissprot:YDHP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDHP_ECOLI pepdigest swissprot:YDHP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDHP_ECOLI pepinfo swissprot:YDHP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDHP_ECOLI pepnet swissprot:YDHP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDHP_ECOLI pepstats swissprot:YDHP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDHP_ECOLI pepwheel swissprot:YDHP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDHP_ECOLI pepwindow swissprot:YDHP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDHP_ECOLI sigcleave swissprot:YDHP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDHP_ECOLI ## Database ID URL or Descriptions # AltName GLPT_ECOLI G-3-P permease # BioGrid 4261310 156 # CDD cd06174 MFS # EcoGene EG10401 glpT # FUNCTION GLPT_ECOLI Responsible for glycerol-3-phosphate uptake. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IBA:GO_Central. # GO_function GLPT_ECOLI GO 0015315 organophosphate inorganic phosphate antiporter activity; IMP EcoCyc. # GO_function GLPT_ECOLI GO 0015527 glycerol-phosphate inorganic phosphate antiporter activity; IDA EcoCyc. # GO_function GO:0015169 glycerol-3-phosphate transmembrane transporter activity; IEA:InterPro. # GO_process GO:0006071 glycerol metabolic process; IEA:UniProtKB-KW. # GO_process GO:0015793 glycerol transport; IDA:EcoCyc. # GO_process GO:0015794 glycerol-3-phosphate transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006810 transport # GOslim_process GO:0044281 small molecule metabolic process # InterPro IPR000849 Sugar_P_transporter # InterPro IPR005267 G3P_transporter # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # InterPro IPR021159 Sugar-P_transporter_CS # KEGG_Brite ko02000 Transporters # Organism GLPT_ECOLI Escherichia coli (strain K12) # PATRIC 32119839 VBIEscCol129921_2329 # PDB 1PW4 X-ray; 3.30 A; A=3-448 # PIR S00868 JNECGT # PIRSF PIRSF002808 Hexose_phosphate_transp # PROSITE PS00942 GLPT # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLPT_ECOLI Glycerol-3-phosphate transporter # RefSeq NP_416743 NC_000913.3 # RefSeq WP_000948731 NZ_LN832404.1 # SIMILARITY Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family. {ECO 0000305}. # SUBCELLULAR LOCATION GLPT_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT GLPT_ECOLI Monomer. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.4 the major facilitator superfamily (mfs) # TIGRFAMs TIGR00712 glpT # eggNOG COG2271 LUCA # eggNOG ENOG4105CXY Bacteria BLAST swissprot:GLPT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLPT_ECOLI BioCyc ECOL316407:JW2234-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2234-MONOMER BioCyc EcoCyc:GLPT-MONOMER http://biocyc.org/getid?id=EcoCyc:GLPT-MONOMER BioCyc MetaCyc:GLPT-MONOMER http://biocyc.org/getid?id=MetaCyc:GLPT-MONOMER COG COG2271 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2271 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1365-2958.1987.tb01931.x http://dx.doi.org/10.1111/j.1365-2958.1987.tb01931.x DOI 10.1111/j.1365-2958.1988.tb00074.x http://dx.doi.org/10.1111/j.1365-2958.1988.tb00074.x DOI 10.1126/science.1087619 http://dx.doi.org/10.1126/science.1087619 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL Y00536 http://www.ebi.ac.uk/ena/data/view/Y00536 EchoBASE EB0396 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0396 EcoGene EG10401 http://www.ecogene.org/geneInfo.php?eg_id=EG10401 EnsemblBacteria AAC75300 http://www.ensemblgenomes.org/id/AAC75300 EnsemblBacteria AAC75300 http://www.ensemblgenomes.org/id/AAC75300 EnsemblBacteria BAA16059 http://www.ensemblgenomes.org/id/BAA16059 EnsemblBacteria BAA16059 http://www.ensemblgenomes.org/id/BAA16059 EnsemblBacteria BAA16059 http://www.ensemblgenomes.org/id/BAA16059 EnsemblBacteria b2240 http://www.ensemblgenomes.org/id/b2240 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015169 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015169 GO_function GO:0015315 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015315 GO_function GO:0015527 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015527 GO_process GO:0006071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006071 GO_process GO:0015793 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015793 GO_process GO:0015794 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015794 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 946704 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946704 HOGENOM HOG000274729 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000274729&db=HOGENOM6 InParanoid P08194 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P08194 IntAct P08194 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P08194* InterPro IPR000849 http://www.ebi.ac.uk/interpro/entry/IPR000849 InterPro IPR005267 http://www.ebi.ac.uk/interpro/entry/IPR005267 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 InterPro IPR021159 http://www.ebi.ac.uk/interpro/entry/IPR021159 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2234 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2234 KEGG_Gene eco:b2240 http://www.genome.jp/dbget-bin/www_bget?eco:b2240 KEGG_Orthology KO:K02445 http://www.genome.jp/dbget-bin/www_bget?KO:K02445 OMA WSTHERG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WSTHERG PDB 1PW4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1PW4 PDBsum 1PW4 http://www.ebi.ac.uk/pdbsum/1PW4 PROSITE PS00942 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00942 PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:GLPT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLPT_ECOLI PSORT-B swissprot:GLPT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLPT_ECOLI PSORT2 swissprot:GLPT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLPT_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:GLPT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLPT_ECOLI PhylomeDB P08194 http://phylomedb.org/?seqid=P08194 ProteinModelPortal P08194 http://www.proteinmodelportal.org/query/uniprot/P08194 PubMed 12893936 http://www.ncbi.nlm.nih.gov/pubmed/12893936 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3141744 http://www.ncbi.nlm.nih.gov/pubmed/3141744 PubMed 3329281 http://www.ncbi.nlm.nih.gov/pubmed/3329281 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416743 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416743 RefSeq WP_000948731 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000948731 SMR P08194 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P08194 STRING 511145.b2240 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2240&targetmode=cogs STRING COG2271 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2271&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.4 http://www.tcdb.org/search/result.php?tc=2.A.1.4 TIGRFAMs TIGR00712 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00712 UniProtKB GLPT_ECOLI http://www.uniprot.org/uniprot/GLPT_ECOLI UniProtKB-AC P08194 http://www.uniprot.org/uniprot/P08194 charge swissprot:GLPT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLPT_ECOLI eggNOG COG2271 http://eggnogapi.embl.de/nog_data/html/tree/COG2271 eggNOG ENOG4105CXY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CXY epestfind swissprot:GLPT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLPT_ECOLI garnier swissprot:GLPT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLPT_ECOLI helixturnhelix swissprot:GLPT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLPT_ECOLI hmoment swissprot:GLPT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLPT_ECOLI iep swissprot:GLPT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLPT_ECOLI inforesidue swissprot:GLPT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLPT_ECOLI octanol swissprot:GLPT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLPT_ECOLI pepcoil swissprot:GLPT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLPT_ECOLI pepdigest swissprot:GLPT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLPT_ECOLI pepinfo swissprot:GLPT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLPT_ECOLI pepnet swissprot:GLPT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLPT_ECOLI pepstats swissprot:GLPT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLPT_ECOLI pepwheel swissprot:GLPT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLPT_ECOLI pepwindow swissprot:GLPT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLPT_ECOLI sigcleave swissprot:GLPT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLPT_ECOLI ## Database ID URL or Descriptions # BioGrid 4260613 6 # CDD cd06174 MFS # EcoGene EG10522 kgtP # FUNCTION KGTP_ECOLI Uptake of alpha-ketoglutarate across the boundary membrane with the concomitant import of a cation (symport system). {ECO 0000269|PubMed 2053984}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function KGTP_ECOLI GO 0015294 solute cation symporter activity; IDA EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # InterPro IPR004736 Cit_H_symport # InterPro IPR005828 MFS_sugar_transport-like # InterPro IPR005829 Sugar_transporter_CS # InterPro IPR020846 MFS_dom # KEGG_Brite ko02000 Transporters # Organism KGTP_ECOLI Escherichia coli (strain K12) # PATRIC 32120575 VBIEscCol129921_2690 # PIR JN0080 JN0080 # PROSITE PS00216 SUGAR_TRANSPORT_1 # PROSITE PS00217 SUGAR_TRANSPORT_2 # PROSITE PS50850 MFS # Pfam PF00083 Sugar_tr; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName KGTP_ECOLI Alpha-ketoglutarate permease # RefSeq NP_417082 NC_000913.3 # RefSeq WP_000841103 NZ_LN832404.1 # SIMILARITY Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. {ECO 0000305}. # SUBCELLULAR LOCATION KGTP_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.6 the major facilitator superfamily (mfs) # TIGRFAMs TIGR00883 2A0106 # eggNOG ENOG4105CSH Bacteria # eggNOG ENOG410XP7I LUCA BLAST swissprot:KGTP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:KGTP_ECOLI BioCyc ECOL316407:JW2571-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2571-MONOMER BioCyc EcoCyc:KGTP-MONOMER http://biocyc.org/getid?id=EcoCyc:KGTP-MONOMER BioCyc MetaCyc:KGTP-MONOMER http://biocyc.org/getid?id=MetaCyc:KGTP-MONOMER COG COG0477 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0477 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.88.9.3802 http://dx.doi.org/10.1073/pnas.88.9.3802 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/nar/18.10.3056 http://dx.doi.org/10.1093/nar/18.10.3056 DOI 10.1093/nar/19.8.1845 http://dx.doi.org/10.1093/nar/19.8.1845 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X52363 http://www.ebi.ac.uk/ena/data/view/X52363 EMBL X53027 http://www.ebi.ac.uk/ena/data/view/X53027 EMBL X56780 http://www.ebi.ac.uk/ena/data/view/X56780 EchoBASE EB0517 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0517 EcoGene EG10522 http://www.ecogene.org/geneInfo.php?eg_id=EG10522 EnsemblBacteria AAC75640 http://www.ensemblgenomes.org/id/AAC75640 EnsemblBacteria AAC75640 http://www.ensemblgenomes.org/id/AAC75640 EnsemblBacteria BAA16472 http://www.ensemblgenomes.org/id/BAA16472 EnsemblBacteria BAA16472 http://www.ensemblgenomes.org/id/BAA16472 EnsemblBacteria BAA16472 http://www.ensemblgenomes.org/id/BAA16472 EnsemblBacteria b2587 http://www.ensemblgenomes.org/id/b2587 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015294 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015294 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GeneID 947069 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947069 HOGENOM HOG000141612 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000141612&db=HOGENOM6 InParanoid P0AEX3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEX3 InterPro IPR004736 http://www.ebi.ac.uk/interpro/entry/IPR004736 InterPro IPR005828 http://www.ebi.ac.uk/interpro/entry/IPR005828 InterPro IPR005829 http://www.ebi.ac.uk/interpro/entry/IPR005829 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2571 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2571 KEGG_Gene eco:b2587 http://www.genome.jp/dbget-bin/www_bget?eco:b2587 KEGG_Orthology KO:K03761 http://www.genome.jp/dbget-bin/www_bget?KO:K03761 OMA IMTVALC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IMTVALC PROSITE PS00216 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00216 PROSITE PS00217 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00217 PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:KGTP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:KGTP_ECOLI PSORT-B swissprot:KGTP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:KGTP_ECOLI PSORT2 swissprot:KGTP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:KGTP_ECOLI Pfam PF00083 http://pfam.xfam.org/family/PF00083 Phobius swissprot:KGTP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:KGTP_ECOLI PhylomeDB P0AEX3 http://phylomedb.org/?seqid=P0AEX3 ProteinModelPortal P0AEX3 http://www.proteinmodelportal.org/query/uniprot/P0AEX3 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1709493 http://www.ncbi.nlm.nih.gov/pubmed/1709493 PubMed 2053984 http://www.ncbi.nlm.nih.gov/pubmed/2053984 PubMed 2118499 http://www.ncbi.nlm.nih.gov/pubmed/2118499 PubMed 2190187 http://www.ncbi.nlm.nih.gov/pubmed/2190187 PubMed 8419306 http://www.ncbi.nlm.nih.gov/pubmed/8419306 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417082 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417082 RefSeq WP_000841103 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000841103 STRING 511145.b2587 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2587&targetmode=cogs STRING COG0477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0477&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.6 http://www.tcdb.org/search/result.php?tc=2.A.1.6 TIGRFAMs TIGR00883 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00883 UniProtKB KGTP_ECOLI http://www.uniprot.org/uniprot/KGTP_ECOLI UniProtKB-AC P0AEX3 http://www.uniprot.org/uniprot/P0AEX3 charge swissprot:KGTP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:KGTP_ECOLI eggNOG ENOG4105CSH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CSH eggNOG ENOG410XP7I http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XP7I epestfind swissprot:KGTP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:KGTP_ECOLI garnier swissprot:KGTP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:KGTP_ECOLI helixturnhelix swissprot:KGTP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:KGTP_ECOLI hmoment swissprot:KGTP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:KGTP_ECOLI iep swissprot:KGTP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:KGTP_ECOLI inforesidue swissprot:KGTP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:KGTP_ECOLI octanol swissprot:KGTP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:KGTP_ECOLI pepcoil swissprot:KGTP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:KGTP_ECOLI pepdigest swissprot:KGTP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:KGTP_ECOLI pepinfo swissprot:KGTP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:KGTP_ECOLI pepnet swissprot:KGTP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:KGTP_ECOLI pepstats swissprot:KGTP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:KGTP_ECOLI pepwheel swissprot:KGTP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:KGTP_ECOLI pepwindow swissprot:KGTP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:KGTP_ECOLI sigcleave swissprot:KGTP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:KGTP_ECOLI ## Database ID URL or Descriptions # EcoGene EG14462 ydgU # INDUCTION Expressed during stationary phase (at protein level). {ECO:0000269|PubMed 19121005}. # Organism YDGU_ECOLI Escherichia coli (strain K12) # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDGU_ECOLI Uncharacterized protein YdgU # RefSeq WP_000233093 NZ_LN832404.1 # RefSeq YP_001165320 NC_000913.3 BLAST swissprot:YDGU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDGU_ECOLI BioCyc EcoCyc:MONOMER0-2821 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2821 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2008.06495.x http://dx.doi.org/10.1111/j.1365-2958.2008.06495.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14462 http://www.ecogene.org/geneInfo.php?eg_id=EG14462 EnsemblBacteria ABP93446 http://www.ensemblgenomes.org/id/ABP93446 EnsemblBacteria ABP93446 http://www.ensemblgenomes.org/id/ABP93446 EnsemblBacteria b4601 http://www.ensemblgenomes.org/id/b4601 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 5061510 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5061510 KEGG_Gene eco:b4601 http://www.genome.jp/dbget-bin/www_bget?eco:b4601 PSORT swissprot:YDGU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDGU_ECOLI PSORT-B swissprot:YDGU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDGU_ECOLI PSORT2 swissprot:YDGU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDGU_ECOLI Phobius swissprot:YDGU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDGU_ECOLI PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19121005 http://www.ncbi.nlm.nih.gov/pubmed/19121005 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000233093 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000233093 RefSeq YP_001165320 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001165320 STRING 511145.b4601 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4601&targetmode=cogs UniProtKB YDGU_ECOLI http://www.uniprot.org/uniprot/YDGU_ECOLI UniProtKB-AC A5A617 http://www.uniprot.org/uniprot/A5A617 charge swissprot:YDGU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDGU_ECOLI epestfind swissprot:YDGU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDGU_ECOLI garnier swissprot:YDGU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDGU_ECOLI helixturnhelix swissprot:YDGU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDGU_ECOLI hmoment swissprot:YDGU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDGU_ECOLI iep swissprot:YDGU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDGU_ECOLI inforesidue swissprot:YDGU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDGU_ECOLI octanol swissprot:YDGU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDGU_ECOLI pepcoil swissprot:YDGU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDGU_ECOLI pepdigest swissprot:YDGU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDGU_ECOLI pepinfo swissprot:YDGU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDGU_ECOLI pepnet swissprot:YDGU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDGU_ECOLI pepstats swissprot:YDGU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDGU_ECOLI pepwheel swissprot:YDGU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDGU_ECOLI pepwindow swissprot:YDGU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDGU_ECOLI sigcleave swissprot:YDGU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDGU_ECOLI ## Database ID URL or Descriptions # AltName YEDQ_ECOLI Cellulose synthesis regulatory protein # BioGrid 4261052 3 # CATALYTIC ACTIVITY YEDQ_ECOLI 2 GTP = 2 diphosphate + cyclic di-3',5'- guanylate. # CDD cd01949 GGDEF # COFACTOR YEDQ_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250}; Note=Binds 1 Mg(2+) ion per monomer. {ECO 0000250}; # DISRUPTION PHENOTYPE Disruption partially suppresses the reduced motility of a yhjH disruption; concomitant disruption of dosC, yegE, yedQ and yfiN completely restores motility, suggesting these 4 genes, together with the c-di-GMP phosphodiesterase YhjH, form a network that regulates cell motility by altering levels of c-di- GMP. {ECO:0000269|PubMed 20303158}. # EcoGene EG14040 yedQ # FUNCTION YEDQ_ECOLI Involved in the regulation of cellulose production. Cyclic-di-GMP is a second messenger which controls cell surface- associated traits in bacteria. {ECO 0000269|PubMed 20303158}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005525 GTP binding; IEA:UniProtKB-KW. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0052621 diguanylate cyclase activity; IEA:UniProtKB-EC. # GO_process GO:0030244 cellulose biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:1902201 negative regulation of bacterial-type flagellum-dependent cell motility; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # INDUCTION YEDQ_ECOLI Constitutively expressed at both 28 and 37 degrees Celsius. Induced by 0.3 M NaCl. Expression is RpoS dependent. {ECO 0000269|PubMed 17010156, ECO 0000269|PubMed 19332833}. # InterPro IPR000160 GGDEF_dom # InterPro IPR029787 Nucleotide_cyclase # InterPro IPR033416 CHASE7 # Organism YEDQ_ECOLI Escherichia coli (strain K12) # PATHWAY YEDQ_ECOLI Glycan metabolism; bacterial cellulose biosynthesis. # PATHWAY YEDQ_ECOLI Purine metabolism; 3',5'-cyclic di-GMP biosynthesis. # PATRIC 32119239 VBIEscCol129921_2034 # PIR H64959 H64959 # PROSITE PS50887 GGDEF # Pfam PF00990 GGDEF # Pfam PF17151 CHASE7 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEDQ_ECOLI Probable diguanylate cyclase YedQ # RefSeq NP_416465 NC_000913.3 # SIMILARITY Contains 1 GGDEF domain. {ECO:0000255|PROSITE- ProRule PRU00095}. # SMART SM00267 GGDEF # SUBCELLULAR LOCATION YEDQ_ECOLI Cell inner membrane {ECO 0000305}; Multi- pass membrane protein {ECO 0000305}. # SUBUNIT Homodimer. {ECO 0000250}. # SUPFAM SSF55073 SSF55073 # TCDB 9.B.34.1 the kinase/phosphatase/cyclic-gmp synthase/cyclic di-gmp hydrolase (kpsh) family # TIGRFAMs TIGR00254 GGDEF # eggNOG ENOG4105BZU Bacteria # eggNOG ENOG410XNMH LUCA BLAST swissprot:YEDQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEDQ_ECOLI BioCyc ECOL316407:JW5832-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5832-MONOMER BioCyc EcoCyc:G7049-MONOMER http://biocyc.org/getid?id=EcoCyc:G7049-MONOMER DOI 10.1016/j.cell.2010.01.018 http://dx.doi.org/10.1016/j.cell.2010.01.018 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1099/mic.0.024257-0 http://dx.doi.org/10.1099/mic.0.024257-0 DOI 10.1111/j.1365-2958.2006.05440.x http://dx.doi.org/10.1111/j.1365-2958.2006.05440.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.188.8.3073-3087.2006 http://dx.doi.org/10.1128/JB.188.8.3073-3087.2006 EC_number EC:2.7.7.65 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.65 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.7.65 http://enzyme.expasy.org/EC/2.7.7.65 EchoBASE EB3794 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3794 EcoGene EG14040 http://www.ecogene.org/geneInfo.php?eg_id=EG14040 EnsemblBacteria AAC75022 http://www.ensemblgenomes.org/id/AAC75022 EnsemblBacteria AAC75022 http://www.ensemblgenomes.org/id/AAC75022 EnsemblBacteria BAA15784 http://www.ensemblgenomes.org/id/BAA15784 EnsemblBacteria BAA15784 http://www.ensemblgenomes.org/id/BAA15784 EnsemblBacteria BAA15784 http://www.ensemblgenomes.org/id/BAA15784 EnsemblBacteria b1956 http://www.ensemblgenomes.org/id/b1956 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0052621 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052621 GO_process GO:0030244 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030244 GO_process GO:1902201 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902201 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 946471 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946471 HOGENOM HOG000121343 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000121343&db=HOGENOM6 IntEnz 2.7.7.65 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.65 InterPro IPR000160 http://www.ebi.ac.uk/interpro/entry/IPR000160 InterPro IPR029787 http://www.ebi.ac.uk/interpro/entry/IPR029787 InterPro IPR033416 http://www.ebi.ac.uk/interpro/entry/IPR033416 KEGG_Gene ecj:JW5832 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5832 KEGG_Gene eco:b1956 http://www.genome.jp/dbget-bin/www_bget?eco:b1956 OMA EAYVANQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EAYVANQ PROSITE PS50887 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50887 PSORT swissprot:YEDQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEDQ_ECOLI PSORT-B swissprot:YEDQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEDQ_ECOLI PSORT2 swissprot:YEDQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEDQ_ECOLI Pfam PF00990 http://pfam.xfam.org/family/PF00990 Pfam PF17151 http://pfam.xfam.org/family/PF17151 Phobius swissprot:YEDQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEDQ_ECOLI ProteinModelPortal P76330 http://www.proteinmodelportal.org/query/uniprot/P76330 PubMed 16585767 http://www.ncbi.nlm.nih.gov/pubmed/16585767 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17010156 http://www.ncbi.nlm.nih.gov/pubmed/17010156 PubMed 19332833 http://www.ncbi.nlm.nih.gov/pubmed/19332833 PubMed 20303158 http://www.ncbi.nlm.nih.gov/pubmed/20303158 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416465 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416465 SMART SM00267 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00267 SMR P76330 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76330 STRING 511145.b1956 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1956&targetmode=cogs SUPFAM SSF55073 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55073 TCDB 9.B.34.1 http://www.tcdb.org/search/result.php?tc=9.B.34.1 TIGRFAMs TIGR00254 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00254 UniProtKB YEDQ_ECOLI http://www.uniprot.org/uniprot/YEDQ_ECOLI UniProtKB-AC P76330 http://www.uniprot.org/uniprot/P76330 charge swissprot:YEDQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEDQ_ECOLI eggNOG ENOG4105BZU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZU eggNOG ENOG410XNMH http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNMH epestfind swissprot:YEDQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEDQ_ECOLI garnier swissprot:YEDQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEDQ_ECOLI helixturnhelix swissprot:YEDQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEDQ_ECOLI hmoment swissprot:YEDQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEDQ_ECOLI iep swissprot:YEDQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEDQ_ECOLI inforesidue swissprot:YEDQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEDQ_ECOLI octanol swissprot:YEDQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEDQ_ECOLI pepcoil swissprot:YEDQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEDQ_ECOLI pepdigest swissprot:YEDQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEDQ_ECOLI pepinfo swissprot:YEDQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEDQ_ECOLI pepnet swissprot:YEDQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEDQ_ECOLI pepstats swissprot:YEDQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEDQ_ECOLI pepwheel swissprot:YEDQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEDQ_ECOLI pepwindow swissprot:YEDQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEDQ_ECOLI sigcleave swissprot:YEDQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEDQ_ECOLI ## Database ID URL or Descriptions # AltName YDIB_ECOLI NAD-dependent shikimate 5-dehydrogenase {ECO 0000255|HAMAP-Rule MF_01578, ECO 0000303|PubMed 3541912} # BIOPHYSICOCHEMICAL PROPERTIES YDIB_ECOLI Kinetic parameters KM=2.9 uM for shikimate (at pH 9 and 20 degrees Celsius) {ECO 0000269|PubMed 15596430}; KM=9.1 uM for quinate (at pH 9 and 20 degrees Celsius) {ECO 0000269|PubMed 15596430}; KM=12.2 uM for NAD (with shikimate at pH 9 and 20 degrees Celsius) {ECO 0000269|PubMed 15596430}; KM=18.4 uM for NAD (with quinate at pH 9 and 20 degrees Celsius) {ECO 0000269|PubMed 15596430}; KM=20 uM for shikimate (with NAD at pH 9 and 20 degrees Celsius) {ECO 0000269|PubMed 12637497}; KM=41 uM for quinate (with NAD at pH 9 and 20 degrees Celsius) {ECO 0000269|PubMed 12637497}; KM=87 uM for NAD (with shikimate at pH 9 and 20 degrees Celsius) {ECO 0000269|PubMed 12637497}; KM=100 uM for NADP (with shikimate at pH 9 and 20 degrees Celsius) {ECO 0000269|PubMed 12637497}; KM=116 uM for NAD (with quinate at pH 9 and 20 degrees Celsius) {ECO 0000269|PubMed 12637497}; KM=120 uM for shikimate (with NADP at pH 9 and 20 degrees Celsius) {ECO 0000269|PubMed 12637497}; KM=500 uM for NADP (with quinate at pH 9 and 20 degrees Celsius) {ECO 0000269|PubMed 12637497}; KM=555 uM for quinate (with NADP at pH 9 and 20 degrees Celsius) {ECO 0000269|PubMed 12637497}; Note=Kcat is 91 sec(-1) for dehydrogenase activity with shikimate (at pH 9 and 20 degrees Celsius). Kcat is 113 sec(-1) for dehydrogenase activity with quinate (at pH 9 and 20 degrees Celsius). Kcat is 105 sec(-1) for dehydrogenase activity with NAD (with shikinate at pH 9 and 20 degrees Celsius). Kcat is 142 sec(-1) for dehydrogenase activity with NAD (with quinate at pH 9 and 20 degrees Celsius).; # BRENDA 1.1.1.282 2026 # BioGrid 4263505 7 # CATALYTIC ACTIVITY YDIB_ECOLI L-quinate + NAD(P)(+) = 3-dehydroquinate + NAD(P)H. {ECO 0000255|HAMAP-Rule MF_01578, ECO 0000269|PubMed 12637497, ECO 0000269|PubMed 15596430}. # CATALYTIC ACTIVITY YDIB_ECOLI Shikimate + NAD(P)(+) = 3-dehydroshikimate + NAD(P)H. {ECO 0000255|HAMAP-Rule MF_01578, ECO 0000269|PubMed 12637497, ECO 0000269|PubMed 15596430}. # EcoGene EG11234 ydiB # FUNCTION YDIB_ECOLI The actual biological function of YdiB remains unclear, nor is it known whether 3-dehydroshikimate or quinate represents the natural substrate. Catalyzes the reversible NAD-dependent reduction of both 3-dehydroshikimate (DHSA) and 3-dehydroquinate to yield shikimate (SA) and quinate, respectively. It can use both NAD or NADP for catalysis, however it has higher catalytic efficiency with NAD. {ECO 0000255|HAMAP-Rule MF_01578, ECO 0000269|PubMed 12624088, ECO 0000269|PubMed 12637497, ECO 0000269|PubMed 15596430}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0000166 nucleotide binding; IDA:EcoCyc. # GO_function GO:0004764 shikimate 3-dehydrogenase (NADP+) activity; IDA:EcoCyc. # GO_function GO:0030266 quinate 3-dehydrogenase (NAD+) activity; IDA:EcoCyc. # GO_function GO:0050661 NADP binding; IDA:EcoCyc. # GO_function GO:0051287 NAD binding; IDA:EcoCyc. # GO_function GO:0052733 quinate 3-dehydrogenase (NADP+) activity; IEA:UniProtKB-EC. # GO_function GO:0052734 shikimate 3-dehydrogenase (NAD+) activity; IDA:EcoCyc. # GO_process GO:0008652 cellular amino acid biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0009073 aromatic amino acid family biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0009423 chorismate biosynthetic process; IBA:GO_Central. # GO_process GO:0019632 shikimate metabolic process; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.720 -; 1. # HAMAP MF_00222 Shikimate_DH_AroE # HAMAP MF_01578 Shikimate_DH_YdiB # INDUCTION Induced under carbon limitation but not under phosphate limitation. {ECO:0000269|PubMed 16828913}. # IntAct P0A6D5 3 # InterPro IPR013708 Shikimate_DH-bd_N # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR022872 Quinate/Shikimate_DH # InterPro IPR022893 Shikimate_DH_fam # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis # MASS SPECTROMETRY Mass=31361; Method=Electrospray; Range=1-288; Evidence={ECO:0000269|PubMed 15596430}; # Organism YDIB_ECOLI Escherichia coli (strain K12) # PATHWAY Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. {ECO 0000255|HAMAP-Rule:MF_01578}. # PATRIC 32118690 VBIEscCol129921_1763 # PDB 1NPD X-ray; 2.30 A; A/B=1-288 # PDB 1O9B X-ray; 2.50 A; A/B=1-288 # PDB 1VI2 X-ray; 2.10 A; A/B=2-288 # PIR D64927 D64927 # Pfam PF08501 Shikimate_dh_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDIB_ECOLI Quinate/shikimate dehydrogenase {ECO 0000255|HAMAP-Rule MF_01578, ECO 0000303|PubMed 3541912} # RefSeq NP_416207 NC_000913.3 # RefSeq WP_000383469 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA27848.1; Type=Frameshift; Positions=170, 200, 212; Evidence={ECO 0000305}; # SIMILARITY Belongs to the shikimate dehydrogenase family. {ECO:0000255|HAMAP-Rule MF_01578}. # SUBUNIT YDIB_ECOLI Homodimer. {ECO 0000255|HAMAP-Rule MF_01578, ECO 0000269|PubMed 12624088, ECO 0000269|PubMed 12637497, ECO 0000269|PubMed 16021622, ECO 0000269|PubMed 3541912}. # SUPFAM SSF51735 SSF51735 # UniPathway UPA00053 UER00087 # eggNOG COG0169 LUCA # eggNOG ENOG4105E2X Bacteria BLAST swissprot:YDIB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDIB_ECOLI BioCyc ECOL316407:JW1682-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1682-MONOMER BioCyc EcoCyc:EG11234-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11234-MONOMER BioCyc MetaCyc:EG11234-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11234-MONOMER COG COG0169 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0169 DIP DIP-47967N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47967N DOI 10.1002/prot.20541 http://dx.doi.org/10.1002/prot.20541 DOI 10.1016/j.jbiotec.2006.05.007 http://dx.doi.org/10.1016/j.jbiotec.2006.05.007 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2380475 http://dx.doi.org/10.1042/bj2380475 DOI 10.1074/jbc.M300794200 http://dx.doi.org/10.1074/jbc.M300794200 DOI 10.1074/jbc.M301348200 http://dx.doi.org/10.1074/jbc.M301348200 DOI 10.1074/jbc.M412028200 http://dx.doi.org/10.1074/jbc.M412028200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.282 {ECO:0000255|HAMAP-Rule:MF_01578, ECO:0000269|PubMed:12637497, ECO:0000269|PubMed:15596430} http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.282 {ECO:0000255|HAMAP-Rule:MF_01578, ECO:0000269|PubMed:12637497, ECO:0000269|PubMed:15596430} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X04306 http://www.ebi.ac.uk/ena/data/view/X04306 ENZYME 1.1.1.282 {ECO:0000255|HAMAP-Rule:MF_01578, ECO:0000269|PubMed:12637497, ECO:0000269|PubMed:15596430} http://enzyme.expasy.org/EC/1.1.1.282 {ECO:0000255|HAMAP-Rule:MF_01578, ECO:0000269|PubMed:12637497, ECO:0000269|PubMed:15596430} EchoBASE EB1216 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1216 EcoGene EG11234 http://www.ecogene.org/geneInfo.php?eg_id=EG11234 EnsemblBacteria AAC74762 http://www.ensemblgenomes.org/id/AAC74762 EnsemblBacteria AAC74762 http://www.ensemblgenomes.org/id/AAC74762 EnsemblBacteria BAA15449 http://www.ensemblgenomes.org/id/BAA15449 EnsemblBacteria BAA15449 http://www.ensemblgenomes.org/id/BAA15449 EnsemblBacteria BAA15449 http://www.ensemblgenomes.org/id/BAA15449 EnsemblBacteria b1692 http://www.ensemblgenomes.org/id/b1692 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000166 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000166 GO_function GO:0004764 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004764 GO_function GO:0030266 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030266 GO_function GO:0050661 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050661 GO_function GO:0051287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051287 GO_function GO:0052733 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052733 GO_function GO:0052734 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052734 GO_process GO:0008652 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008652 GO_process GO:0009073 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009073 GO_process GO:0009423 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009423 GO_process GO:0019632 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019632 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 946200 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946200 HAMAP MF_00222 http://hamap.expasy.org/unirule/MF_00222 HAMAP MF_01578 http://hamap.expasy.org/unirule/MF_01578 HOGENOM HOG000237875 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000237875&db=HOGENOM6 InParanoid P0A6D5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6D5 IntAct P0A6D5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6D5* IntEnz 1.1.1.282 {ECO:0000255|HAMAP-Rule:MF_01578, ECO:0000269|PubMed:12637497, ECO:0000269|PubMed:15596430} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.282 {ECO:0000255|HAMAP-Rule:MF_01578, ECO:0000269|PubMed:12637497, ECO:0000269|PubMed:15596430} InterPro IPR013708 http://www.ebi.ac.uk/interpro/entry/IPR013708 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR022872 http://www.ebi.ac.uk/interpro/entry/IPR022872 InterPro IPR022893 http://www.ebi.ac.uk/interpro/entry/IPR022893 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1682 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1682 KEGG_Gene eco:b1692 http://www.genome.jp/dbget-bin/www_bget?eco:b1692 KEGG_Orthology KO:K05887 http://www.genome.jp/dbget-bin/www_bget?KO:K05887 KEGG_Pathway ko00400 http://www.genome.jp/kegg-bin/show_pathway?ko00400 KEGG_Reaction rn:R01872 http://www.genome.jp/dbget-bin/www_bget?rn:R01872 KEGG_Reaction rn:R02413 http://www.genome.jp/dbget-bin/www_bget?rn:R02413 KEGG_Reaction rn:R06846 http://www.genome.jp/dbget-bin/www_bget?rn:R06846 KEGG_Reaction rn:R06847 http://www.genome.jp/dbget-bin/www_bget?rn:R06847 MINT MINT-1283305 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1283305 OMA PFIHNSA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PFIHNSA PDB 1NPD http://www.ebi.ac.uk/pdbe-srv/view/entry/1NPD PDB 1O9B http://www.ebi.ac.uk/pdbe-srv/view/entry/1O9B PDB 1VI2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1VI2 PDBsum 1NPD http://www.ebi.ac.uk/pdbsum/1NPD PDBsum 1O9B http://www.ebi.ac.uk/pdbsum/1O9B PDBsum 1VI2 http://www.ebi.ac.uk/pdbsum/1VI2 PSORT swissprot:YDIB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDIB_ECOLI PSORT-B swissprot:YDIB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDIB_ECOLI PSORT2 swissprot:YDIB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDIB_ECOLI Pfam PF08501 http://pfam.xfam.org/family/PF08501 Phobius swissprot:YDIB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDIB_ECOLI PhylomeDB P0A6D5 http://phylomedb.org/?seqid=P0A6D5 ProteinModelPortal P0A6D5 http://www.proteinmodelportal.org/query/uniprot/P0A6D5 PubMed 12624088 http://www.ncbi.nlm.nih.gov/pubmed/12624088 PubMed 12637497 http://www.ncbi.nlm.nih.gov/pubmed/12637497 PubMed 15596430 http://www.ncbi.nlm.nih.gov/pubmed/15596430 PubMed 16021622 http://www.ncbi.nlm.nih.gov/pubmed/16021622 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16828913 http://www.ncbi.nlm.nih.gov/pubmed/16828913 PubMed 3541912 http://www.ncbi.nlm.nih.gov/pubmed/3541912 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416207 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416207 RefSeq WP_000383469 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000383469 SMR P0A6D5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6D5 STRING 511145.b1692 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1692&targetmode=cogs STRING COG0169 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0169&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB YDIB_ECOLI http://www.uniprot.org/uniprot/YDIB_ECOLI UniProtKB-AC P0A6D5 http://www.uniprot.org/uniprot/P0A6D5 charge swissprot:YDIB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDIB_ECOLI eggNOG COG0169 http://eggnogapi.embl.de/nog_data/html/tree/COG0169 eggNOG ENOG4105E2X http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E2X epestfind swissprot:YDIB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDIB_ECOLI garnier swissprot:YDIB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDIB_ECOLI helixturnhelix swissprot:YDIB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDIB_ECOLI hmoment swissprot:YDIB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDIB_ECOLI iep swissprot:YDIB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDIB_ECOLI inforesidue swissprot:YDIB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDIB_ECOLI octanol swissprot:YDIB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDIB_ECOLI pepcoil swissprot:YDIB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDIB_ECOLI pepdigest swissprot:YDIB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDIB_ECOLI pepinfo swissprot:YDIB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDIB_ECOLI pepnet swissprot:YDIB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDIB_ECOLI pepstats swissprot:YDIB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDIB_ECOLI pepwheel swissprot:YDIB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDIB_ECOLI pepwindow swissprot:YDIB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDIB_ECOLI sigcleave swissprot:YDIB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDIB_ECOLI ## Database ID URL or Descriptions # AltName GAL7_ECOLI UDP-glucose--hexose-1-phosphate uridylyltransferase # BIOPHYSICOCHEMICAL PROPERTIES GAL7_ECOLI Kinetic parameters KM=0.200 mM for uridine 5'-diphosphate glucose {ECO 0000269|PubMed 10820011}; KM=0.303 mM for galactose-1-phosphate {ECO 0000269|PubMed 10820011}; KM=0.121 mM for uridine 5'-diphosphate galactose {ECO 0000269|PubMed 10820011}; KM=0.157 mM for glucose-1-phosphate {ECO 0000269|PubMed 10820011}; Vmax=180 umol/min/mg enzyme {ECO 0000269|PubMed 10820011}; # BRENDA 2.7.7.12 2026 # BioGrid 4261703 381 # CATALYTIC ACTIVITY GAL7_ECOLI UDP-alpha-D-glucose + alpha-D-galactose 1- phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose. # COFACTOR Name=Fe cation; Xref=ChEBI:CHEBI 24875; Note=Binds 1 Fe cation per subunit.; # COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI 29105; Note=Binds 1 zinc ion per subunit.; # EcoGene EG10366 galT # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GAL7_ECOLI GO 0008108 UDP-glucose hexose-1-phosphate uridylyltransferase activity; IDA EcoCyc. # GO_function GO:0004335 galactokinase activity; IMP:CACAO. # GO_function GO:0008198 ferrous iron binding; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_process GO:0033499 galactose catabolic process via UDP-galactose; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.30.428.10 -; 2. # InterPro IPR001937 GalP_UDPtransf1 # InterPro IPR005849 GalP_Utransf_N # InterPro IPR005850 GalP_Utransf_C # InterPro IPR011146 HIT-like # InterPro IPR019779 GalP_UDPtransf1_His-AS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00052 Galactose metabolism # KEGG_Pathway ko00520 Amino sugar and nucleotide sugar metabolism # Organism GAL7_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11943 PTHR11943 # PATHWAY GAL7_ECOLI Carbohydrate metabolism; galactose metabolism. # PATRIC 32116717 VBIEscCol129921_0784 # PDB 1GUP X-ray; 1.80 A; A/B/C/D=1-348 # PDB 1GUQ X-ray; 1.80 A; A/B/C/D=1-348 # PDB 1HXP X-ray; 1.80 A; A/B=1-348 # PDB 1HXQ X-ray; 1.86 A; A/B=1-348 # PIR S00722 XNECUD # PIRSF PIRSF000808 GalT # PROSITE PS00117 GAL_P_UDP_TRANSF_I # Pfam PF01087 GalP_UDP_transf # Pfam PF02744 GalP_UDP_tr_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GAL7_ECOLI Galactose-1-phosphate uridylyltransferase # RefSeq NP_415279 NC_000913.3 # RefSeq WP_000191497 NZ_LN832404.1 # SIMILARITY Belongs to the galactose-1-phosphate uridylyltransferase type 1 family. {ECO 0000305}. # SUBUNIT GAL7_ECOLI Homodimer. # SUPFAM SSF54197 SSF54197; 2 # TIGRFAMs TIGR00209 galT_1 # eggNOG COG1085 LUCA # eggNOG ENOG4105F0Z Bacteria BLAST swissprot:GAL7_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GAL7_ECOLI BioCyc ECOL316407:JW0741-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0741-MONOMER BioCyc EcoCyc:GALACTURIDYLYLTRANS-MONOMER http://biocyc.org/getid?id=EcoCyc:GALACTURIDYLYLTRANS-MONOMER BioCyc MetaCyc:GALACTURIDYLYLTRANS-MONOMER http://biocyc.org/getid?id=MetaCyc:GALACTURIDYLYLTRANS-MONOMER COG COG1085 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1085 DIP DIP-9735N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9735N DOI 10.1021/bi00035a010 http://dx.doi.org/10.1021/bi00035a010 DOI 10.1021/bi00624a032 http://dx.doi.org/10.1021/bi00624a032 DOI 10.1021/bi9612677 http://dx.doi.org/10.1021/bi9612677 DOI 10.1021/bi9626517 http://dx.doi.org/10.1021/bi9626517 DOI 10.1021/bi992594s http://dx.doi.org/10.1021/bi992594s DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/13.6.1841 http://dx.doi.org/10.1093/nar/13.6.1841 DOI 10.1093/nar/14.19.7705 http://dx.doi.org/10.1093/nar/14.19.7705 DOI 10.1093/nar/15.19.8116 http://dx.doi.org/10.1093/nar/15.19.8116 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.7.12 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.12 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X02306 http://www.ebi.ac.uk/ena/data/view/X02306 EMBL X06226 http://www.ebi.ac.uk/ena/data/view/X06226 ENZYME 2.7.7.12 http://enzyme.expasy.org/EC/2.7.7.12 EchoBASE EB0361 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0361 EcoGene EG10366 http://www.ecogene.org/geneInfo.php?eg_id=EG10366 EnsemblBacteria AAC73845 http://www.ensemblgenomes.org/id/AAC73845 EnsemblBacteria AAC73845 http://www.ensemblgenomes.org/id/AAC73845 EnsemblBacteria BAA35420 http://www.ensemblgenomes.org/id/BAA35420 EnsemblBacteria BAA35420 http://www.ensemblgenomes.org/id/BAA35420 EnsemblBacteria BAA35420 http://www.ensemblgenomes.org/id/BAA35420 EnsemblBacteria b0758 http://www.ensemblgenomes.org/id/b0758 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004335 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004335 GO_function GO:0008108 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008108 GO_function GO:0008198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008198 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_process GO:0033499 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033499 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.30.428.10 http://www.cathdb.info/version/latest/superfamily/3.30.428.10 GeneID 945357 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945357 HOGENOM HOG000230490 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230490&db=HOGENOM6 InParanoid P09148 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P09148 IntAct P09148 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P09148* IntEnz 2.7.7.12 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.12 InterPro IPR001937 http://www.ebi.ac.uk/interpro/entry/IPR001937 InterPro IPR005849 http://www.ebi.ac.uk/interpro/entry/IPR005849 InterPro IPR005850 http://www.ebi.ac.uk/interpro/entry/IPR005850 InterPro IPR011146 http://www.ebi.ac.uk/interpro/entry/IPR011146 InterPro IPR019779 http://www.ebi.ac.uk/interpro/entry/IPR019779 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0741 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0741 KEGG_Gene eco:b0758 http://www.genome.jp/dbget-bin/www_bget?eco:b0758 KEGG_Orthology KO:K00965 http://www.genome.jp/dbget-bin/www_bget?KO:K00965 KEGG_Pathway ko00052 http://www.genome.jp/kegg-bin/show_pathway?ko00052 KEGG_Pathway ko00520 http://www.genome.jp/kegg-bin/show_pathway?ko00520 KEGG_Reaction rn:R00955 http://www.genome.jp/dbget-bin/www_bget?rn:R00955 OMA GQWVLVC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GQWVLVC PANTHER PTHR11943 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11943 PDB 1GUP http://www.ebi.ac.uk/pdbe-srv/view/entry/1GUP PDB 1GUQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1GUQ PDB 1HXP http://www.ebi.ac.uk/pdbe-srv/view/entry/1HXP PDB 1HXQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1HXQ PDBsum 1GUP http://www.ebi.ac.uk/pdbsum/1GUP PDBsum 1GUQ http://www.ebi.ac.uk/pdbsum/1GUQ PDBsum 1HXP http://www.ebi.ac.uk/pdbsum/1HXP PDBsum 1HXQ http://www.ebi.ac.uk/pdbsum/1HXQ PROSITE PS00117 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00117 PSORT swissprot:GAL7_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GAL7_ECOLI PSORT-B swissprot:GAL7_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GAL7_ECOLI PSORT2 swissprot:GAL7_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GAL7_ECOLI Pfam PF01087 http://pfam.xfam.org/family/PF01087 Pfam PF02744 http://pfam.xfam.org/family/PF02744 Phobius swissprot:GAL7_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GAL7_ECOLI PhylomeDB P09148 http://phylomedb.org/?seqid=P09148 ProteinModelPortal P09148 http://www.proteinmodelportal.org/query/uniprot/P09148 PubMed 10820011 http://www.ncbi.nlm.nih.gov/pubmed/10820011 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2823224 http://www.ncbi.nlm.nih.gov/pubmed/2823224 PubMed 3022232 http://www.ncbi.nlm.nih.gov/pubmed/3022232 PubMed 3158881 http://www.ncbi.nlm.nih.gov/pubmed/3158881 PubMed 321007 http://www.ncbi.nlm.nih.gov/pubmed/321007 PubMed 7669762 http://www.ncbi.nlm.nih.gov/pubmed/7669762 PubMed 8794735 http://www.ncbi.nlm.nih.gov/pubmed/8794735 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9063869 http://www.ncbi.nlm.nih.gov/pubmed/9063869 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415279 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415279 RefSeq WP_000191497 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000191497 SMR P09148 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P09148 STRING 511145.b0758 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0758&targetmode=cogs STRING COG1085 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1085&targetmode=cogs SUPFAM SSF54197 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54197 TIGRFAMs TIGR00209 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00209 UniProtKB GAL7_ECOLI http://www.uniprot.org/uniprot/GAL7_ECOLI UniProtKB-AC P09148 http://www.uniprot.org/uniprot/P09148 charge swissprot:GAL7_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GAL7_ECOLI eggNOG COG1085 http://eggnogapi.embl.de/nog_data/html/tree/COG1085 eggNOG ENOG4105F0Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F0Z epestfind swissprot:GAL7_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GAL7_ECOLI garnier swissprot:GAL7_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GAL7_ECOLI helixturnhelix swissprot:GAL7_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GAL7_ECOLI hmoment swissprot:GAL7_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GAL7_ECOLI iep swissprot:GAL7_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GAL7_ECOLI inforesidue swissprot:GAL7_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GAL7_ECOLI octanol swissprot:GAL7_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GAL7_ECOLI pepcoil swissprot:GAL7_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GAL7_ECOLI pepdigest swissprot:GAL7_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GAL7_ECOLI pepinfo swissprot:GAL7_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GAL7_ECOLI pepnet swissprot:GAL7_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GAL7_ECOLI pepstats swissprot:GAL7_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GAL7_ECOLI pepwheel swissprot:GAL7_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GAL7_ECOLI pepwindow swissprot:GAL7_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GAL7_ECOLI sigcleave swissprot:GAL7_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GAL7_ECOLI ## Database ID URL or Descriptions # BioGrid 4260529 12 # EcoGene EG14117 yfcN # HAMAP MF_01042 UPF0115 # IntAct P0A8B2 6 # InterPro IPR002625 Smr_dom # InterPro IPR022990 UPF0115 # Organism YFCN_ECOLI Escherichia coli (strain K12) # PATRIC 32120035 VBIEscCol129921_2427 # PIR A65006 A65006 # PROSITE PS50828 SMR # Pfam PF01713 Smr # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFCN_ECOLI UPF0115 protein YfcN # RefSeq NP_416834 NC_000913.3 # RefSeq WP_000730806 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0115 family. {ECO 0000305}. # SIMILARITY Contains 1 Smr domain. {ECO 0000305}. # SMART SM00463 SMR # SUPFAM SSF160443 SSF160443 # eggNOG COG2840 LUCA # eggNOG ENOG4108DG9 Bacteria BLAST swissprot:YFCN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFCN_ECOLI BioCyc ECOL316407:JW2328-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2328-MONOMER BioCyc EcoCyc:G7202-MONOMER http://biocyc.org/getid?id=EcoCyc:G7202-MONOMER DIP DIP-48186N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48186N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3870 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3870 EcoGene EG14117 http://www.ecogene.org/geneInfo.php?eg_id=EG14117 EnsemblBacteria AAC75391 http://www.ensemblgenomes.org/id/AAC75391 EnsemblBacteria AAC75391 http://www.ensemblgenomes.org/id/AAC75391 EnsemblBacteria BAA16189 http://www.ensemblgenomes.org/id/BAA16189 EnsemblBacteria BAA16189 http://www.ensemblgenomes.org/id/BAA16189 EnsemblBacteria BAA16189 http://www.ensemblgenomes.org/id/BAA16189 EnsemblBacteria b2331 http://www.ensemblgenomes.org/id/b2331 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 944847 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944847 HAMAP MF_01042 http://hamap.expasy.org/unirule/MF_01042 HOGENOM HOG000257487 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000257487&db=HOGENOM6 IntAct P0A8B2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8B2* InterPro IPR002625 http://www.ebi.ac.uk/interpro/entry/IPR002625 InterPro IPR022990 http://www.ebi.ac.uk/interpro/entry/IPR022990 KEGG_Gene ecj:JW2328 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2328 KEGG_Gene eco:b2331 http://www.genome.jp/dbget-bin/www_bget?eco:b2331 OMA EHVYCAS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EHVYCAS PROSITE PS50828 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50828 PSORT swissprot:YFCN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFCN_ECOLI PSORT-B swissprot:YFCN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFCN_ECOLI PSORT2 swissprot:YFCN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFCN_ECOLI Pfam PF01713 http://pfam.xfam.org/family/PF01713 Phobius swissprot:YFCN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFCN_ECOLI PhylomeDB P0A8B2 http://phylomedb.org/?seqid=P0A8B2 ProteinModelPortal P0A8B2 http://www.proteinmodelportal.org/query/uniprot/P0A8B2 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416834 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416834 RefSeq WP_000730806 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000730806 SMART SM00463 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00463 SMR P0A8B2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8B2 STRING 511145.b2331 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2331&targetmode=cogs SUPFAM SSF160443 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF160443 UniProtKB YFCN_ECOLI http://www.uniprot.org/uniprot/YFCN_ECOLI UniProtKB-AC P0A8B2 http://www.uniprot.org/uniprot/P0A8B2 charge swissprot:YFCN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFCN_ECOLI eggNOG COG2840 http://eggnogapi.embl.de/nog_data/html/tree/COG2840 eggNOG ENOG4108DG9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108DG9 epestfind swissprot:YFCN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFCN_ECOLI garnier swissprot:YFCN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFCN_ECOLI helixturnhelix swissprot:YFCN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFCN_ECOLI hmoment swissprot:YFCN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFCN_ECOLI iep swissprot:YFCN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFCN_ECOLI inforesidue swissprot:YFCN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFCN_ECOLI octanol swissprot:YFCN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFCN_ECOLI pepcoil swissprot:YFCN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFCN_ECOLI pepdigest swissprot:YFCN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFCN_ECOLI pepinfo swissprot:YFCN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFCN_ECOLI pepnet swissprot:YFCN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFCN_ECOLI pepstats swissprot:YFCN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFCN_ECOLI pepwheel swissprot:YFCN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFCN_ECOLI pepwindow swissprot:YFCN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFCN_ECOLI sigcleave swissprot:YFCN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFCN_ECOLI ## Database ID URL or Descriptions # BioGrid 4259858 341 # EcoGene EG13253 ybaY # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GOslim_component GO:0005886 plasma membrane # IntAct P77717 2 # Organism YBAY_ECOLI Escherichia coli (strain K12) # PATRIC 32116061 VBIEscCol129921_0472 # PIR E64775 E64775 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBAY_ECOLI Uncharacterized lipoprotein YbaY # RefSeq NP_414987 NC_000913.3 # RefSeq WP_000779842 NZ_LN832404.1 # SUBCELLULAR LOCATION YBAY_ECOLI Cell membrane {ECO 0000305}; Lipid-anchor {ECO 0000305}. # eggNOG COG3126 LUCA # eggNOG ENOG4108MNP Bacteria BLAST swissprot:YBAY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBAY_ECOLI BioCyc ECOL316407:JW0443-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0443-MONOMER BioCyc EcoCyc:G6250-MONOMER http://biocyc.org/getid?id=EcoCyc:G6250-MONOMER COG COG3126 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3126 DIP DIP-11312N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11312N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EchoBASE EB3042 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3042 EcoGene EG13253 http://www.ecogene.org/geneInfo.php?eg_id=EG13253 EnsemblBacteria AAC73556 http://www.ensemblgenomes.org/id/AAC73556 EnsemblBacteria AAC73556 http://www.ensemblgenomes.org/id/AAC73556 EnsemblBacteria BAE76233 http://www.ensemblgenomes.org/id/BAE76233 EnsemblBacteria BAE76233 http://www.ensemblgenomes.org/id/BAE76233 EnsemblBacteria BAE76233 http://www.ensemblgenomes.org/id/BAE76233 EnsemblBacteria b0453 http://www.ensemblgenomes.org/id/b0453 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 945070 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945070 HOGENOM HOG000294260 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000294260&db=HOGENOM6 InParanoid P77717 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77717 IntAct P77717 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77717* KEGG_Gene ecj:JW0443 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0443 KEGG_Gene eco:b0453 http://www.genome.jp/dbget-bin/www_bget?eco:b0453 KEGG_Orthology KO:K09914 http://www.genome.jp/dbget-bin/www_bget?KO:K09914 MINT MINT-1300646 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1300646 OMA GKQAPFQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GKQAPFQ PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YBAY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBAY_ECOLI PSORT-B swissprot:YBAY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBAY_ECOLI PSORT2 swissprot:YBAY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBAY_ECOLI Phobius swissprot:YBAY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBAY_ECOLI PhylomeDB P77717 http://phylomedb.org/?seqid=P77717 ProteinModelPortal P77717 http://www.proteinmodelportal.org/query/uniprot/P77717 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414987 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414987 RefSeq WP_000779842 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000779842 STRING 511145.b0453 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0453&targetmode=cogs STRING COG3126 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3126&targetmode=cogs UniProtKB YBAY_ECOLI http://www.uniprot.org/uniprot/YBAY_ECOLI UniProtKB-AC P77717 http://www.uniprot.org/uniprot/P77717 charge swissprot:YBAY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBAY_ECOLI eggNOG COG3126 http://eggnogapi.embl.de/nog_data/html/tree/COG3126 eggNOG ENOG4108MNP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MNP epestfind swissprot:YBAY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBAY_ECOLI garnier swissprot:YBAY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBAY_ECOLI helixturnhelix swissprot:YBAY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBAY_ECOLI hmoment swissprot:YBAY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBAY_ECOLI iep swissprot:YBAY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBAY_ECOLI inforesidue swissprot:YBAY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBAY_ECOLI octanol swissprot:YBAY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBAY_ECOLI pepcoil swissprot:YBAY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBAY_ECOLI pepdigest swissprot:YBAY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBAY_ECOLI pepinfo swissprot:YBAY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBAY_ECOLI pepnet swissprot:YBAY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBAY_ECOLI pepstats swissprot:YBAY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBAY_ECOLI pepwheel swissprot:YBAY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBAY_ECOLI pepwindow swissprot:YBAY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBAY_ECOLI sigcleave swissprot:YBAY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBAY_ECOLI ## Database ID URL or Descriptions # BioGrid 4260053 15 # DOMAIN EFEO_ECOLI Contains an N-terminal Cup-like domain and a C-terminal peptidase domain, separated by a flexible linker. Structural modeling identifies 2 potential metal-binding sites in the Cup- like domain, with site I binding Cu(2+) and site II favoring Fe(3+). The peptidase domain may also contain an iron-binding site. {ECO 0000269|PubMed 19701722}. # EcoGene EG13861 efeO # FUNCTION EFEO_ECOLI Involved in Fe(2+) uptake. Could be an iron-binding and/or electron-transfer component. {ECO 0000269|PubMed 19701722}. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_process GO:0006974 cellular response to DNA damage stimulus; IMP:EcoCyc. # GO_process GO:0010043 response to zinc ion; IEP:EcoCyc. # GO_process GO:0046677 response to antibiotic; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # Gene3D 2.60.40.420 -; 1. # INDUCTION EFEO_ECOLI Repressed by Fur in the presence of iron. Repressed at high pH by the two-component regulatory system CpxA/CpxR. {ECO 0000269|PubMed 12746439, ECO 0000269|PubMed 17627767}. # IntAct P0AB24 7 # InterPro IPR008972 Cupredoxin # InterPro IPR028096 EfeO_Cupredoxin # KEGG_Brite ko02000 Transporters # Organism EFEO_ECOLI Escherichia coli (strain K12) # PATRIC 32117269 VBIEscCol129921_1058 # PIR H64843 H64843 # Pfam PF13473 Cupredoxin_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EFEO_ECOLI Iron uptake system component EfeO # RefSeq NP_415537 NC_000913.3 # RefSeq WP_000154398 NZ_LN832404.1 # SIMILARITY Belongs to the EfeM/EfeO family. {ECO 0000305}. # SUBCELLULAR LOCATION EFEO_ECOLI Periplasm {ECO 0000269|PubMed 16551627}. # SUBUNIT EFEO_ECOLI Monomer. Part of a ferrous iron transporter composed of EfeU, EfeO and EfeB. However, this EfeUOB tripartite iron transporter is defective in E.coli strain K12 due to a frameshift mutation in EfeU. {ECO 0000269|PubMed 16551627, ECO 0000269|PubMed 17627767}. # SUPFAM SSF49503 SSF49503 # TCDB 2.A.108.2 the iron/lead transporter (ilt) family # eggNOG COG2822 LUCA # eggNOG ENOG410650H Bacteria BLAST swissprot:EFEO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EFEO_ECOLI BioCyc ECOL316407:JW1003-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1003-MONOMER BioCyc EcoCyc:G6527-MONOMER http://biocyc.org/getid?id=EcoCyc:G6527-MONOMER BioCyc MetaCyc:G6527-MONOMER http://biocyc.org/getid?id=MetaCyc:G6527-MONOMER COG COG2822 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2822 DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1007/s10534-009-9262-z http://dx.doi.org/10.1007/s10534-009-9262-z DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M303381200 http://dx.doi.org/10.1074/jbc.M303381200 DOI 10.1074/jbc.M511891200 http://dx.doi.org/10.1074/jbc.M511891200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.2007.05802.x http://dx.doi.org/10.1111/j.1365-2958.2007.05802.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3621 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3621 EcoGene EG13861 http://www.ecogene.org/geneInfo.php?eg_id=EG13861 EnsemblBacteria AAC74103 http://www.ensemblgenomes.org/id/AAC74103 EnsemblBacteria AAC74103 http://www.ensemblgenomes.org/id/AAC74103 EnsemblBacteria BAA35795 http://www.ensemblgenomes.org/id/BAA35795 EnsemblBacteria BAA35795 http://www.ensemblgenomes.org/id/BAA35795 EnsemblBacteria BAA35795 http://www.ensemblgenomes.org/id/BAA35795 EnsemblBacteria b1018 http://www.ensemblgenomes.org/id/b1018 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0010043 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010043 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 2.60.40.420 http://www.cathdb.info/version/latest/superfamily/2.60.40.420 GeneID 945603 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945603 HOGENOM HOG000236929 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000236929&db=HOGENOM6 InParanoid P0AB24 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AB24 IntAct P0AB24 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AB24* InterPro IPR008972 http://www.ebi.ac.uk/interpro/entry/IPR008972 InterPro IPR028096 http://www.ebi.ac.uk/interpro/entry/IPR028096 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1003 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1003 KEGG_Gene eco:b1018 http://www.genome.jp/dbget-bin/www_bget?eco:b1018 KEGG_Orthology KO:K07224 http://www.genome.jp/dbget-bin/www_bget?KO:K07224 OMA PQLQKEN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PQLQKEN PSORT swissprot:EFEO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EFEO_ECOLI PSORT-B swissprot:EFEO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EFEO_ECOLI PSORT2 swissprot:EFEO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EFEO_ECOLI Pfam PF13473 http://pfam.xfam.org/family/PF13473 Phobius swissprot:EFEO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EFEO_ECOLI PhylomeDB P0AB24 http://phylomedb.org/?seqid=P0AB24 ProteinModelPortal P0AB24 http://www.proteinmodelportal.org/query/uniprot/P0AB24 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 12746439 http://www.ncbi.nlm.nih.gov/pubmed/12746439 PubMed 16551627 http://www.ncbi.nlm.nih.gov/pubmed/16551627 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17627767 http://www.ncbi.nlm.nih.gov/pubmed/17627767 PubMed 19701722 http://www.ncbi.nlm.nih.gov/pubmed/19701722 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415537 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415537 RefSeq WP_000154398 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000154398 SMR P0AB24 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AB24 STRING 511145.b1018 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1018&targetmode=cogs STRING COG2822 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2822&targetmode=cogs SUPFAM SSF49503 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49503 TCDB 2.A.108.2 http://www.tcdb.org/search/result.php?tc=2.A.108.2 UniProtKB EFEO_ECOLI http://www.uniprot.org/uniprot/EFEO_ECOLI UniProtKB-AC P0AB24 http://www.uniprot.org/uniprot/P0AB24 charge swissprot:EFEO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EFEO_ECOLI eggNOG COG2822 http://eggnogapi.embl.de/nog_data/html/tree/COG2822 eggNOG ENOG410650H http://eggnogapi.embl.de/nog_data/html/tree/ENOG410650H epestfind swissprot:EFEO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EFEO_ECOLI garnier swissprot:EFEO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EFEO_ECOLI helixturnhelix swissprot:EFEO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EFEO_ECOLI hmoment swissprot:EFEO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EFEO_ECOLI iep swissprot:EFEO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EFEO_ECOLI inforesidue swissprot:EFEO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EFEO_ECOLI octanol swissprot:EFEO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EFEO_ECOLI pepcoil swissprot:EFEO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EFEO_ECOLI pepdigest swissprot:EFEO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EFEO_ECOLI pepinfo swissprot:EFEO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EFEO_ECOLI pepnet swissprot:EFEO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EFEO_ECOLI pepstats swissprot:EFEO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EFEO_ECOLI pepwheel swissprot:EFEO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EFEO_ECOLI pepwindow swissprot:EFEO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EFEO_ECOLI sigcleave swissprot:EFEO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EFEO_ECOLI ## Database ID URL or Descriptions # BioGrid 4262966 4 # EcoGene EG14105 yfbU # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_process GO:0006950 response to stress # Gene3D 1.10.287.680 -; 1. # Gene3D 1.10.3190.10 -; 1. # HAMAP MF_00762 UPF0304 # INDUCTION Only a leaderless mRNA has been detected in vivo, the first nucleotide is the beginning of the start codon. {ECO:0000269|PubMed 21944167}. # IntAct P0A8W8 9 # InterPro IPR005587 UPF0304_YfbU # InterPro IPR023145 YfbU_helix-hairpin # InterPro IPR023146 YfbU_alpha-helical # Organism YFBU_ECOLI Escherichia coli (strain K12) # PATRIC 32119957 VBIEscCol129921_2388 # PIRSF PIRSF006272 UCP006272 # Pfam PF03887 YfbU # ProDom PD035118 YfbU # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFBU_ECOLI UPF0304 protein YfbU # RefSeq NP_416797 NC_000913.3 # RefSeq WP_000426124 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0304 family. {ECO 0000305}. # eggNOG COG3013 LUCA # eggNOG ENOG4105XWI Bacteria BLAST swissprot:YFBU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFBU_ECOLI BioCyc ECOL316407:JW2291-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2291-MONOMER BioCyc EcoCyc:G7188-MONOMER http://biocyc.org/getid?id=EcoCyc:G7188-MONOMER COG COG3013 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3013 DIP DIP-48184N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48184N DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1016/j.cell.2011.07.047 http://dx.doi.org/10.1016/j.cell.2011.07.047 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3858 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3858 EcoGene EG14105 http://www.ecogene.org/geneInfo.php?eg_id=EG14105 EnsemblBacteria AAC75354 http://www.ensemblgenomes.org/id/AAC75354 EnsemblBacteria AAC75354 http://www.ensemblgenomes.org/id/AAC75354 EnsemblBacteria BAE76685 http://www.ensemblgenomes.org/id/BAE76685 EnsemblBacteria BAE76685 http://www.ensemblgenomes.org/id/BAE76685 EnsemblBacteria BAE76685 http://www.ensemblgenomes.org/id/BAE76685 EnsemblBacteria b2294 http://www.ensemblgenomes.org/id/b2294 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 1.10.287.680 http://www.cathdb.info/version/latest/superfamily/1.10.287.680 Gene3D 1.10.3190.10 http://www.cathdb.info/version/latest/superfamily/1.10.3190.10 GeneID 946767 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946767 HAMAP MF_00762 http://hamap.expasy.org/unirule/MF_00762 HOGENOM HOG000272587 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000272587&db=HOGENOM6 InParanoid P0A8W8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8W8 IntAct P0A8W8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8W8* InterPro IPR005587 http://www.ebi.ac.uk/interpro/entry/IPR005587 InterPro IPR023145 http://www.ebi.ac.uk/interpro/entry/IPR023145 InterPro IPR023146 http://www.ebi.ac.uk/interpro/entry/IPR023146 KEGG_Gene ecj:JW2291 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2291 KEGG_Gene eco:b2294 http://www.genome.jp/dbget-bin/www_bget?eco:b2294 KEGG_Orthology KO:K09161 http://www.genome.jp/dbget-bin/www_bget?KO:K09161 OMA DKADHHF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DKADHHF PSORT swissprot:YFBU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFBU_ECOLI PSORT-B swissprot:YFBU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFBU_ECOLI PSORT2 swissprot:YFBU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFBU_ECOLI Pfam PF03887 http://pfam.xfam.org/family/PF03887 Phobius swissprot:YFBU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFBU_ECOLI ProteinModelPortal P0A8W8 http://www.proteinmodelportal.org/query/uniprot/P0A8W8 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21944167 http://www.ncbi.nlm.nih.gov/pubmed/21944167 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416797 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416797 RefSeq WP_000426124 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000426124 SMR P0A8W8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8W8 STRING 511145.b2294 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2294&targetmode=cogs STRING COG3013 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3013&targetmode=cogs UniProtKB YFBU_ECOLI http://www.uniprot.org/uniprot/YFBU_ECOLI UniProtKB-AC P0A8W8 http://www.uniprot.org/uniprot/P0A8W8 charge swissprot:YFBU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFBU_ECOLI eggNOG COG3013 http://eggnogapi.embl.de/nog_data/html/tree/COG3013 eggNOG ENOG4105XWI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105XWI epestfind swissprot:YFBU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFBU_ECOLI garnier swissprot:YFBU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFBU_ECOLI helixturnhelix swissprot:YFBU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFBU_ECOLI hmoment swissprot:YFBU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFBU_ECOLI iep swissprot:YFBU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFBU_ECOLI inforesidue swissprot:YFBU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFBU_ECOLI octanol swissprot:YFBU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFBU_ECOLI pepcoil swissprot:YFBU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFBU_ECOLI pepdigest swissprot:YFBU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFBU_ECOLI pepinfo swissprot:YFBU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFBU_ECOLI pepnet swissprot:YFBU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFBU_ECOLI pepstats swissprot:YFBU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFBU_ECOLI pepwheel swissprot:YFBU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFBU_ECOLI pepwindow swissprot:YFBU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFBU_ECOLI sigcleave swissprot:YFBU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFBU_ECOLI ## Database ID URL or Descriptions # EcoGene EG14350 yjbS # Organism YJBS_ECOLI Escherichia coli (strain K12) # PATRIC 32123651 VBIEscCol129921_4174 # Proteomes UP000000625 Chromosome # RecName YJBS_ECOLI Uncharacterized protein YjbS # RefSeq YP_001165333 NC_000913.3 BLAST swissprot:YJBS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJBS_ECOLI BioCyc EcoCyc:MONOMER0-2829 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2829 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14350 http://www.ecogene.org/geneInfo.php?eg_id=EG14350 EnsemblBacteria ABP93458 http://www.ensemblgenomes.org/id/ABP93458 EnsemblBacteria ABP93458 http://www.ensemblgenomes.org/id/ABP93458 EnsemblBacteria b4621 http://www.ensemblgenomes.org/id/b4621 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 5061529 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5061529 KEGG_Gene eco:b4621 http://www.genome.jp/dbget-bin/www_bget?eco:b4621 PSORT swissprot:YJBS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJBS_ECOLI PSORT-B swissprot:YJBS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJBS_ECOLI PSORT2 swissprot:YJBS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJBS_ECOLI Phobius swissprot:YJBS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJBS_ECOLI ProteinModelPortal P58036 http://www.proteinmodelportal.org/query/uniprot/P58036 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq YP_001165333 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001165333 STRING 511145.b4621 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4621&targetmode=cogs UniProtKB YJBS_ECOLI http://www.uniprot.org/uniprot/YJBS_ECOLI UniProtKB-AC P58036 http://www.uniprot.org/uniprot/P58036 charge swissprot:YJBS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJBS_ECOLI epestfind swissprot:YJBS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJBS_ECOLI garnier swissprot:YJBS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJBS_ECOLI helixturnhelix swissprot:YJBS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJBS_ECOLI hmoment swissprot:YJBS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJBS_ECOLI iep swissprot:YJBS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJBS_ECOLI inforesidue swissprot:YJBS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJBS_ECOLI octanol swissprot:YJBS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJBS_ECOLI pepcoil swissprot:YJBS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJBS_ECOLI pepdigest swissprot:YJBS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJBS_ECOLI pepinfo swissprot:YJBS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJBS_ECOLI pepnet swissprot:YJBS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJBS_ECOLI pepstats swissprot:YJBS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJBS_ECOLI pepwheel swissprot:YJBS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJBS_ECOLI pepwindow swissprot:YJBS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJBS_ECOLI sigcleave swissprot:YJBS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJBS_ECOLI ## Database ID URL or Descriptions # AltName AGAL_ECOLI Melibiase # BioGrid 4262685 7 # CATALYTIC ACTIVITY AGAL_ECOLI Hydrolysis of terminal, non-reducing alpha-D- galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids. # CAZy GH4 Glycoside Hydrolase Family 4 # COFACTOR AGAL_ECOLI Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 2831880}; Note=Binds 1 Mn(2+) ion per subunit. {ECO 0000269|PubMed 2831880}; # COFACTOR AGAL_ECOLI Name=NAD(+); Xref=ChEBI CHEBI 57540; Evidence={ECO 0000269|PubMed 2831880}; Note=Binds 1 NAD(+) per subunit. {ECO 0000269|PubMed 2831880}; # EcoGene EG10577 melA # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004557 alpha-galactosidase activity; IDA:EcoCyc. # GO_function GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro. # GO_function GO:0030145 manganese ion binding; IDA:EcoCyc. # GO_function GO:0052692 raffinose alpha-galactosidase activity; IEA:UniProtKB-EC. # GO_function GO:0070403 NAD+ binding; IDA:EcoCyc. # GO_process GO:0005995 melibiose catabolic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # Gene3D 3.40.50.720 -; 1. # Gene3D 3.90.110.10 -; 1. # IntAct P06720 3 # InterPro IPR001088 Glyco_hydro_4 # InterPro IPR015955 Lactate_DH/Glyco_Ohase_4_C # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR019802 GlycHydrolase_4_CS # InterPro IPR022616 Glyco_hydro_4_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00052 Galactose metabolism # KEGG_Pathway ko00561 Glycerolipid metabolism # KEGG_Pathway ko00600 Sphingolipid metabolism # KEGG_Pathway ko00603 Glycosphingolipid biosynthesis - globo series # Organism AGAL_ECOLI Escherichia coli (strain K12) # PATRIC 32123803 VBIEscCol129921_4250 # PIR A26571 GBECAG # PRINTS PR00732 GLHYDRLASE4 # PROSITE PS01324 GLYCOSYL_HYDROL_F4 # Pfam PF02056 Glyco_hydro_4 # Pfam PF11975 Glyco_hydro_4C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AGAL_ECOLI Alpha-galactosidase # RefSeq NP_418543 NC_000913.3 # RefSeq WP_000986601 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA24149.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the glycosyl hydrolase 4 family. {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 2831880}. # SUPFAM SSF51735 SSF51735 # SUPFAM SSF56327 SSF56327 # eggNOG COG1486 LUCA # eggNOG ENOG4105F8D Bacteria BLAST swissprot:AGAL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AGAL_ECOLI BioCyc ECOL316407:JW4080-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4080-MONOMER BioCyc EcoCyc:ALPHAGALACTOSID-MONOMER http://biocyc.org/getid?id=EcoCyc:ALPHAGALACTOSID-MONOMER BioCyc MetaCyc:ALPHAGALACTOSID-MONOMER http://biocyc.org/getid?id=MetaCyc:ALPHAGALACTOSID-MONOMER COG COG1486 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1486 DIP DIP-10179N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10179N DOI 10.1016/0006-291X(84)90685-5 http://dx.doi.org/10.1016/0006-291X(84)90685-5 DOI 10.1016/0006-291X(88)90584-0 http://dx.doi.org/10.1016/0006-291X(88)90584-0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/15.5.2213 http://dx.doi.org/10.1093/nar/15.5.2213 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.2.1.22 http://www.genome.jp/dbget-bin/www_bget?EC:3.2.1.22 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K01490 http://www.ebi.ac.uk/ena/data/view/K01490 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X04894 http://www.ebi.ac.uk/ena/data/view/X04894 ENZYME 3.2.1.22 http://enzyme.expasy.org/EC/3.2.1.22 EchoBASE EB0572 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0572 EcoGene EG10577 http://www.ecogene.org/geneInfo.php?eg_id=EG10577 EnsemblBacteria AAC77080 http://www.ensemblgenomes.org/id/AAC77080 EnsemblBacteria AAC77080 http://www.ensemblgenomes.org/id/AAC77080 EnsemblBacteria BAE78121 http://www.ensemblgenomes.org/id/BAE78121 EnsemblBacteria BAE78121 http://www.ensemblgenomes.org/id/BAE78121 EnsemblBacteria BAE78121 http://www.ensemblgenomes.org/id/BAE78121 EnsemblBacteria b4119 http://www.ensemblgenomes.org/id/b4119 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004557 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004557 GO_function GO:0016616 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016616 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_function GO:0052692 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052692 GO_function GO:0070403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070403 GO_process GO:0005995 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005995 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 Gene3D 3.90.110.10 http://www.cathdb.info/version/latest/superfamily/3.90.110.10 GeneID 948636 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948636 HOGENOM HOG000239812 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000239812&db=HOGENOM6 InParanoid P06720 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P06720 IntAct P06720 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P06720* IntEnz 3.2.1.22 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.2.1.22 InterPro IPR001088 http://www.ebi.ac.uk/interpro/entry/IPR001088 InterPro IPR015955 http://www.ebi.ac.uk/interpro/entry/IPR015955 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR019802 http://www.ebi.ac.uk/interpro/entry/IPR019802 InterPro IPR022616 http://www.ebi.ac.uk/interpro/entry/IPR022616 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4080 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4080 KEGG_Gene eco:b4119 http://www.genome.jp/dbget-bin/www_bget?eco:b4119 KEGG_Orthology KO:K07406 http://www.genome.jp/dbget-bin/www_bget?KO:K07406 KEGG_Pathway ko00052 http://www.genome.jp/kegg-bin/show_pathway?ko00052 KEGG_Pathway ko00561 http://www.genome.jp/kegg-bin/show_pathway?ko00561 KEGG_Pathway ko00600 http://www.genome.jp/kegg-bin/show_pathway?ko00600 KEGG_Pathway ko00603 http://www.genome.jp/kegg-bin/show_pathway?ko00603 KEGG_Reaction rn:R01101 http://www.genome.jp/dbget-bin/www_bget?rn:R01101 KEGG_Reaction rn:R01103 http://www.genome.jp/dbget-bin/www_bget?rn:R01103 KEGG_Reaction rn:R01104 http://www.genome.jp/dbget-bin/www_bget?rn:R01104 KEGG_Reaction rn:R01194 http://www.genome.jp/dbget-bin/www_bget?rn:R01194 KEGG_Reaction rn:R01329 http://www.genome.jp/dbget-bin/www_bget?rn:R01329 KEGG_Reaction rn:R02926 http://www.genome.jp/dbget-bin/www_bget?rn:R02926 KEGG_Reaction rn:R03634 http://www.genome.jp/dbget-bin/www_bget?rn:R03634 KEGG_Reaction rn:R04019 http://www.genome.jp/dbget-bin/www_bget?rn:R04019 KEGG_Reaction rn:R04470 http://www.genome.jp/dbget-bin/www_bget?rn:R04470 KEGG_Reaction rn:R05549 http://www.genome.jp/dbget-bin/www_bget?rn:R05549 KEGG_Reaction rn:R05961 http://www.genome.jp/dbget-bin/www_bget?rn:R05961 KEGG_Reaction rn:R06091 http://www.genome.jp/dbget-bin/www_bget?rn:R06091 OMA NLPKEAC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NLPKEAC PRINTS PR00732 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00732 PROSITE PS01324 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01324 PSORT swissprot:AGAL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AGAL_ECOLI PSORT-B swissprot:AGAL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AGAL_ECOLI PSORT2 swissprot:AGAL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AGAL_ECOLI Pfam PF02056 http://pfam.xfam.org/family/PF02056 Pfam PF11975 http://pfam.xfam.org/family/PF11975 Phobius swissprot:AGAL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AGAL_ECOLI PhylomeDB P06720 http://phylomedb.org/?seqid=P06720 ProteinModelPortal P06720 http://www.proteinmodelportal.org/query/uniprot/P06720 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2831880 http://www.ncbi.nlm.nih.gov/pubmed/2831880 PubMed 3031590 http://www.ncbi.nlm.nih.gov/pubmed/3031590 PubMed 6329200 http://www.ncbi.nlm.nih.gov/pubmed/6329200 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418543 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418543 RefSeq WP_000986601 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000986601 SMR P06720 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P06720 STRING 511145.b4119 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4119&targetmode=cogs STRING COG1486 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1486&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 SUPFAM SSF56327 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56327 UniProtKB AGAL_ECOLI http://www.uniprot.org/uniprot/AGAL_ECOLI UniProtKB-AC P06720 http://www.uniprot.org/uniprot/P06720 charge swissprot:AGAL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AGAL_ECOLI eggNOG COG1486 http://eggnogapi.embl.de/nog_data/html/tree/COG1486 eggNOG ENOG4105F8D http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F8D epestfind swissprot:AGAL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AGAL_ECOLI garnier swissprot:AGAL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AGAL_ECOLI helixturnhelix swissprot:AGAL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AGAL_ECOLI hmoment swissprot:AGAL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AGAL_ECOLI iep swissprot:AGAL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AGAL_ECOLI inforesidue swissprot:AGAL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AGAL_ECOLI octanol swissprot:AGAL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AGAL_ECOLI pepcoil swissprot:AGAL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AGAL_ECOLI pepdigest swissprot:AGAL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AGAL_ECOLI pepinfo swissprot:AGAL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AGAL_ECOLI pepnet swissprot:AGAL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AGAL_ECOLI pepstats swissprot:AGAL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AGAL_ECOLI pepwheel swissprot:AGAL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AGAL_ECOLI pepwindow swissprot:AGAL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AGAL_ECOLI sigcleave swissprot:AGAL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AGAL_ECOLI ## Database ID URL or Descriptions # BioGrid 4260523 8 # CDD cd06261 TM_PBP2 # EcoGene EG12125 hisQ # FUNCTION HISQ_ECOLI Part of the histidine permease ABC transporter. Also part of a lysine/arginine/ornithine transporter. Probably responsible for the translocation of the substrate across the membrane. Required to relay the ATPase-inducing signal from the solute-binding protein to HisP (By similarity). {ECO 0000250}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005215 transporter activity; IEA:InterPro. # GO_process GO:0003333 amino acid transmembrane transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0055085 transmembrane transport # Gene3D 1.10.3720.10 -; 1. # InterPro IPR000515 MetI-like # InterPro IPR010065 AA_ABC_transptr_permease_3TM # InterPro IPR030199 HisQ # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00225 Lysine/arginine/ornithine transport system # KEGG_Brite ko02000 M00226 Histidine transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism HISQ_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30133:SF1 PTHR30133:SF1 # PATRIC 32119987 VBIEscCol129921_2403 # PIR B65003 B65003 # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HISQ_ECOLI Histidine transport system permease protein HisQ # RefSeq NP_416811 NC_000913.3 # RefSeq WP_000965522 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION HISQ_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00441, ECO 0000269|PubMed 15919996}. # SUBUNIT The complex is composed of two ATP-binding proteins (HisP), two transmembrane proteins (HisM and HisQ) and a solute- binding protein (HisJ or ArgT). {ECO 0000250}. # SUPFAM SSF161098 SSF161098 # TCDB 3.A.1.3.29 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR01726 HEQRo_perm_3TM # eggNOG COG4215 LUCA # eggNOG ENOG4105DSP Bacteria BLAST swissprot:HISQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HISQ_ECOLI BioCyc ECOL316407:JW2305-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2305-MONOMER BioCyc EcoCyc:HISQ-MONOMER http://biocyc.org/getid?id=EcoCyc:HISQ-MONOMER COG COG4215 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4215 DIP DIP-9912N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9912N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U47027 http://www.ebi.ac.uk/ena/data/view/U47027 EchoBASE EB2046 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2046 EcoGene EG12125 http://www.ecogene.org/geneInfo.php?eg_id=EG12125 EnsemblBacteria AAC75368 http://www.ensemblgenomes.org/id/AAC75368 EnsemblBacteria AAC75368 http://www.ensemblgenomes.org/id/AAC75368 EnsemblBacteria BAA16154 http://www.ensemblgenomes.org/id/BAA16154 EnsemblBacteria BAA16154 http://www.ensemblgenomes.org/id/BAA16154 EnsemblBacteria BAA16154 http://www.ensemblgenomes.org/id/BAA16154 EnsemblBacteria b2308 http://www.ensemblgenomes.org/id/b2308 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_process GO:0003333 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003333 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 947235 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947235 HOGENOM HOG000267551 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267551&db=HOGENOM6 InParanoid P52094 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P52094 InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 InterPro IPR010065 http://www.ebi.ac.uk/interpro/entry/IPR010065 InterPro IPR030199 http://www.ebi.ac.uk/interpro/entry/IPR030199 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2305 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2305 KEGG_Gene eco:b2308 http://www.genome.jp/dbget-bin/www_bget?eco:b2308 KEGG_Orthology KO:K10016 http://www.genome.jp/dbget-bin/www_bget?KO:K10016 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA MWLERRY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MWLERRY PANTHER PTHR30133:SF1 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30133:SF1 PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:HISQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HISQ_ECOLI PSORT-B swissprot:HISQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HISQ_ECOLI PSORT2 swissprot:HISQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HISQ_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Phobius swissprot:HISQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HISQ_ECOLI PhylomeDB P52094 http://phylomedb.org/?seqid=P52094 ProteinModelPortal P52094 http://www.proteinmodelportal.org/query/uniprot/P52094 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416811 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416811 RefSeq WP_000965522 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000965522 SMR P52094 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P52094 STRING 511145.b2308 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2308&targetmode=cogs STRING COG4215 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4215&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.3.29 http://www.tcdb.org/search/result.php?tc=3.A.1.3.29 TIGRFAMs TIGR01726 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01726 UniProtKB HISQ_ECOLI http://www.uniprot.org/uniprot/HISQ_ECOLI UniProtKB-AC P52094 http://www.uniprot.org/uniprot/P52094 charge swissprot:HISQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HISQ_ECOLI eggNOG COG4215 http://eggnogapi.embl.de/nog_data/html/tree/COG4215 eggNOG ENOG4105DSP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DSP epestfind swissprot:HISQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HISQ_ECOLI garnier swissprot:HISQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HISQ_ECOLI helixturnhelix swissprot:HISQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HISQ_ECOLI hmoment swissprot:HISQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HISQ_ECOLI iep swissprot:HISQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HISQ_ECOLI inforesidue swissprot:HISQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HISQ_ECOLI octanol swissprot:HISQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HISQ_ECOLI pepcoil swissprot:HISQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HISQ_ECOLI pepdigest swissprot:HISQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HISQ_ECOLI pepinfo swissprot:HISQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HISQ_ECOLI pepnet swissprot:HISQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HISQ_ECOLI pepstats swissprot:HISQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HISQ_ECOLI pepwheel swissprot:HISQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HISQ_ECOLI pepwindow swissprot:HISQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HISQ_ECOLI sigcleave swissprot:HISQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HISQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4262991 7 # EcoGene EG13422 feaR # FUNCTION FEAR_ECOLI Positive regulator of tynA/maoA and feaB/padA, the genes for 2-phenylethylamine catabolism. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0000987 core promoter proximal region sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.60 -; 2. # IntAct Q47129 3 # InterPro IPR003313 AraC-bd # InterPro IPR009057 Homeodomain-like # InterPro IPR018060 HTH_AraC # InterPro IPR020449 Tscrpt_reg_HTH_AraC-type # KEGG_Brite ko03000 Transcription factors # Organism FEAR_ECOLI Escherichia coli (strain K12) # PATRIC 32118054 VBIEscCol129921_1447 # PIR C64889 C64889 # PRINTS PR00032 HTHARAC # PROSITE PS01124 HTH_ARAC_FAMILY_2 # Pfam PF12833 HTH_18 # Pfam PF14525 AraC_binding_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FEAR_ECOLI Transcriptional activator FeaR # RefSeq NP_415902 NC_000913.3 # RefSeq WP_001067514 NZ_LN832404.1 # SIMILARITY Contains 1 HTH araC/xylS-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00593}. # SMART SM00342 HTH_ARAC # SUPFAM SSF46689 SSF46689 # SUPFAM SSF51215 SSF51215 # eggNOG COG2207 LUCA # eggNOG ENOG4108WFR Bacteria BLAST swissprot:FEAR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FEAR_ECOLI BioCyc ECOL316407:JW1379-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1379-MONOMER BioCyc EcoCyc:G6706-MONOMER http://biocyc.org/getid?id=EcoCyc:G6706-MONOMER COG COG2207 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2207 DOI 10.1016/S0014-5793(97)00228-7 http://dx.doi.org/10.1016/S0014-5793(97)00228-7 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1099/00221287-143-2-513 http://dx.doi.org/10.1099/00221287-143-2-513 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D67041 http://www.ebi.ac.uk/ena/data/view/D67041 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X97453 http://www.ebi.ac.uk/ena/data/view/X97453 EMBL X99402 http://www.ebi.ac.uk/ena/data/view/X99402 EchoBASE EB3198 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3198 EcoGene EG13422 http://www.ecogene.org/geneInfo.php?eg_id=EG13422 EnsemblBacteria AAC74466 http://www.ensemblgenomes.org/id/AAC74466 EnsemblBacteria AAC74466 http://www.ensemblgenomes.org/id/AAC74466 EnsemblBacteria BAE76422 http://www.ensemblgenomes.org/id/BAE76422 EnsemblBacteria BAE76422 http://www.ensemblgenomes.org/id/BAE76422 EnsemblBacteria BAE76422 http://www.ensemblgenomes.org/id/BAE76422 EnsemblBacteria b1384 http://www.ensemblgenomes.org/id/b1384 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000987 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000987 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 GeneID 945941 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945941 HOGENOM HOG000294467 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000294467&db=HOGENOM6 InParanoid Q47129 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q47129 IntAct Q47129 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q47129* InterPro IPR003313 http://www.ebi.ac.uk/interpro/entry/IPR003313 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR018060 http://www.ebi.ac.uk/interpro/entry/IPR018060 InterPro IPR020449 http://www.ebi.ac.uk/interpro/entry/IPR020449 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW1379 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1379 KEGG_Gene eco:b1384 http://www.genome.jp/dbget-bin/www_bget?eco:b1384 KEGG_Orthology KO:K14063 http://www.genome.jp/dbget-bin/www_bget?KO:K14063 OMA YTVFQLE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YTVFQLE PRINTS PR00032 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00032 PROSITE PS01124 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01124 PSORT swissprot:FEAR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FEAR_ECOLI PSORT-B swissprot:FEAR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FEAR_ECOLI PSORT2 swissprot:FEAR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FEAR_ECOLI Pfam PF12833 http://pfam.xfam.org/family/PF12833 Pfam PF14525 http://pfam.xfam.org/family/PF14525 Phobius swissprot:FEAR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FEAR_ECOLI PhylomeDB Q47129 http://phylomedb.org/?seqid=Q47129 ProteinModelPortal Q47129 http://www.proteinmodelportal.org/query/uniprot/Q47129 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8631685 http://www.ncbi.nlm.nih.gov/pubmed/8631685 PubMed 9043126 http://www.ncbi.nlm.nih.gov/pubmed/9043126 PubMed 9109378 http://www.ncbi.nlm.nih.gov/pubmed/9109378 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415902 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415902 RefSeq WP_001067514 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001067514 SMART SM00342 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00342 SMR Q47129 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q47129 STRING 511145.b1384 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1384&targetmode=cogs STRING COG2207 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2207&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF51215 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51215 UniProtKB FEAR_ECOLI http://www.uniprot.org/uniprot/FEAR_ECOLI UniProtKB-AC Q47129 http://www.uniprot.org/uniprot/Q47129 charge swissprot:FEAR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FEAR_ECOLI eggNOG COG2207 http://eggnogapi.embl.de/nog_data/html/tree/COG2207 eggNOG ENOG4108WFR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108WFR epestfind swissprot:FEAR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FEAR_ECOLI garnier swissprot:FEAR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FEAR_ECOLI helixturnhelix swissprot:FEAR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FEAR_ECOLI hmoment swissprot:FEAR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FEAR_ECOLI iep swissprot:FEAR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FEAR_ECOLI inforesidue swissprot:FEAR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FEAR_ECOLI octanol swissprot:FEAR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FEAR_ECOLI pepcoil swissprot:FEAR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FEAR_ECOLI pepdigest swissprot:FEAR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FEAR_ECOLI pepinfo swissprot:FEAR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FEAR_ECOLI pepnet swissprot:FEAR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FEAR_ECOLI pepstats swissprot:FEAR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FEAR_ECOLI pepwheel swissprot:FEAR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FEAR_ECOLI pepwindow swissprot:FEAR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FEAR_ECOLI sigcleave swissprot:FEAR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FEAR_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES APHA_ECOLI Kinetic parameters KM=3.0 uM for 5'-AMP (at 37 degrees Celsius) {ECO 0000269|PubMed 16297670, ECO 0000269|PubMed 9011040}; KM=15.0 uM for 5'-GMP (at 37 degrees Celsius) {ECO 0000269|PubMed 16297670, ECO 0000269|PubMed 9011040}; KM=15.0 uM for 5'-UMP (at 37 degrees Celsius) {ECO 0000269|PubMed 16297670, ECO 0000269|PubMed 9011040}; KM=138.0 uM for 5'-CMP (at 37 degrees Celsius) {ECO 0000269|PubMed 16297670, ECO 0000269|PubMed 9011040}; KM=0.9 uM for 3'-AMP (at 37 degrees Celsius) {ECO 0000269|PubMed 16297670, ECO 0000269|PubMed 9011040}; KM=1.7 uM for 3'-GMP (at 37 degrees Celsius) {ECO 0000269|PubMed 16297670, ECO 0000269|PubMed 9011040}; KM=1.2 uM for 3'-UMP (at 37 degrees Celsius) {ECO 0000269|PubMed 16297670, ECO 0000269|PubMed 9011040}; KM=9.0 uM for 3'-CMP (at 37 degrees Celsius) {ECO 0000269|PubMed 16297670, ECO 0000269|PubMed 9011040}; KM=0.8 uM for 5'-dAMP (at 37 degrees Celsius) {ECO 0000269|PubMed 16297670, ECO 0000269|PubMed 9011040}; KM=3.0 uM for 5'-dGMP (at 37 degrees Celsius) {ECO 0000269|PubMed 16297670, ECO 0000269|PubMed 9011040}; KM=10.0 uM for 5'-dUMP (at 37 degrees Celsius) {ECO 0000269|PubMed 16297670, ECO 0000269|PubMed 9011040}; KM=35.0 uM for 5'-dCMP (at 37 degrees Celsius) {ECO 0000269|PubMed 16297670, ECO 0000269|PubMed 9011040}; KM=1.5 uM for 3'-dAMP (at 37 degrees Celsius) {ECO 0000269|PubMed 16297670, ECO 0000269|PubMed 9011040}; KM=1.6 uM for 3'-dGMP (at 37 degrees Celsius) {ECO 0000269|PubMed 16297670, ECO 0000269|PubMed 9011040}; KM=0.9 uM for 3'-dUMP (at 37 degrees Celsius) {ECO 0000269|PubMed 16297670, ECO 0000269|PubMed 9011040}; KM=1.3 uM for 3'-dCMP (at 37 degrees Celsius) {ECO 0000269|PubMed 16297670, ECO 0000269|PubMed 9011040}; KM=169.0 uM for pNPP (at 37 degrees Celsius) {ECO 0000269|PubMed 16297670, ECO 0000269|PubMed 9011040}; KM=980.0 uM for ribose 5-phosphate (at 37 degrees Celsius) {ECO 0000269|PubMed 16297670, ECO 0000269|PubMed 9011040}; KM=1288.0 uM for glucose 6-phosphate (at 37 degrees Celsius) {ECO 0000269|PubMed 16297670, ECO 0000269|PubMed 9011040}; KM=666.0 uM for beta-glycerol phosphate (at 37 degrees Celsius) {ECO 0000269|PubMed 16297670, ECO 0000269|PubMed 9011040}; pH dependence Optimum pH is 6-6.5 with 5'-AMP as substrate, and pH 5.5-6 with 3'-AMP or pNPP as substrate. {ECO 0000269|PubMed 16297670, ECO 0000269|PubMed 9011040}; # BRENDA 3.1.3 2026 # BioGrid 4259337 10 # CATALYTIC ACTIVITY APHA_ECOLI A phosphate monoester + H(2)O = an alcohol + phosphate. {ECO 0000269|PubMed 12777773, ECO 0000269|PubMed 16297670, ECO 0000269|PubMed 18845157, ECO 0000269|PubMed 9011040}. # COFACTOR APHA_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 14687572, ECO 0000269|PubMed 16330049, ECO 0000269|PubMed 18845157}; Note=Binds 1 Mg(2+) ion per subunit. {ECO 0000269|PubMed 14687572, ECO 0000269|PubMed 16330049, ECO 0000269|PubMed 18845157}; # ENZYME REGULATION APHA_ECOLI Activated by ethanol. Inhibited strongly by EDTA and more weakly by other divalent ions chelators 1,10- phenanthroline, EGTA and dipicolinic acid. Inhibited also by nucleosides, inorganic phosphate and Ca(2+). Unaffected by F(-). {ECO 0000269|PubMed 16297670, ECO 0000269|PubMed 9011040}. # EcoGene EG11934 aphA # FUNCTION APHA_ECOLI Dephosphorylates several organic phosphate monoesters including 3'- and 5'-nucleotides, 2'-deoxy-5'-nucleotides, pNPP, phenyl phosphate, glycerol 2-phosphate, ribose 5-phosphate, O- phospho-L-amino acids and phytic acid, showing the highest activity with aryl phosphoesters (pNPP, phenyl phosphate and O- phospho-L-tyrosine), and to a lesser extent with 3'- and 5'- nucleotides. No activity toward ATP, phosphodiesters, glycerol-1- phosphate, glucose 1-phosphate, glucose 6-phosphate, NADP, GTP or 3',5'-cAMP, ADP or ATP. Also has a phosphotransferase activity catalyzing the transfer of low-energy phosphate groups from organic phosphate monoesters to free hydroxyl groups of various organic compounds. Capable of transferring phosphate from either pNPP or UMP to adenosine or uridine. Does not exhibit nucleotide phosphomutase activity. {ECO 0000269|PubMed 16297670, ECO 0000269|PubMed 9011040}. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0003993 acid phosphatase activity; IDA:EcoCyc. # GO_function GO:0004647 phosphoserine phosphatase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0048037 cofactor binding; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.1000 -; 1. # IntAct P0AE22 2 # InterPro IPR005519 Acid_phosphat_B-like # InterPro IPR010025 HAD-SF_ppase_IIIB_AphA # InterPro IPR023214 HAD-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00627 Aminobenzoate degradation # KEGG_Pathway ko00740 Riboflavin metabolism # Organism APHA_ECOLI Escherichia coli (strain K12) # PATRIC 32123655 VBIEscCol129921_4176 # PDB 1N8N X-ray; 1.69 A; A=26-237 # PDB 1N9K X-ray; 2.20 A; A/B=26-237 # PDB 1RMQ X-ray; 2.00 A; A/B=26-237 # PDB 1RMT X-ray; 1.40 A; A/B/C/D=26-237 # PDB 1RMY X-ray; 1.75 A; A/B=26-237 # PDB 2B82 X-ray; 1.25 A; A/B=27-237 # PDB 2B8J X-ray; 2.03 A; A/B=27-237 # PDB 2G1A X-ray; 2.00 A; A/B=26-237 # PDB 2HEG X-ray; 1.50 A; A/B=27-237 # PDB 2HF7 X-ray; 1.60 A; A/B=27-237 # PDB 3CZ4 X-ray; 1.70 A; A=26-237 # PIR S54790 S54790 # PIRSF PIRSF017818 Acid_Ptase_B # Pfam PF03767 Acid_phosphat_B # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName APHA_ECOLI Class B acid phosphatase # RefSeq NP_418479 NC_000913.3 # RefSeq WP_001226928 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAC43149.1; Type=Frameshift; Positions=62; Evidence={ECO 0000305}; # SIMILARITY Belongs to the class B bacterial acid phosphatase family. {ECO 0000305}. # SUBCELLULAR LOCATION APHA_ECOLI Periplasm {ECO 0000269|PubMed 9011040}. # SUBUNIT APHA_ECOLI Homotetramer. {ECO 0000269|PubMed 14687572, ECO 0000269|PubMed 16330049, ECO 0000269|PubMed 18845157, ECO 0000269|PubMed 9011040}. # SUPFAM SSF56784 SSF56784 # TIGRFAMs TIGR01672 AphA # eggNOG COG3700 LUCA # eggNOG ENOG4105F0S Bacteria BLAST swissprot:APHA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:APHA_ECOLI BioCyc ECOL316407:JW4015-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4015-MONOMER BioCyc EcoCyc:APHA-MONOMER http://biocyc.org/getid?id=EcoCyc:APHA-MONOMER BioCyc MetaCyc:APHA-MONOMER http://biocyc.org/getid?id=MetaCyc:APHA-MONOMER COG COG3700 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3700 DIP DIP-9116N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9116N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1016/j.bbapap.2005.08.028 http://dx.doi.org/10.1016/j.bbapap.2005.08.028 DOI 10.1016/j.jmb.2003.10.050 http://dx.doi.org/10.1016/j.jmb.2003.10.050 DOI 10.1016/j.jmb.2005.10.068 http://dx.doi.org/10.1016/j.jmb.2005.10.068 DOI 10.1016/j.jmb.2008.09.050 http://dx.doi.org/10.1016/j.jmb.2008.09.050 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1107/S0907444903006826 http://dx.doi.org/10.1107/S0907444903006826 DOI 10.1111/j.1574-6968.1997.tb10192.x http://dx.doi.org/10.1111/j.1574-6968.1997.tb10192.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.3.2 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U51210 http://www.ebi.ac.uk/ena/data/view/U51210 EMBL X86971 http://www.ebi.ac.uk/ena/data/view/X86971 ENZYME 3.1.3.2 http://enzyme.expasy.org/EC/3.1.3.2 EchoBASE EB1878 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1878 EcoGene EG11934 http://www.ecogene.org/geneInfo.php?eg_id=EG11934 EnsemblBacteria AAC77025 http://www.ensemblgenomes.org/id/AAC77025 EnsemblBacteria AAC77025 http://www.ensemblgenomes.org/id/AAC77025 EnsemblBacteria BAE78057 http://www.ensemblgenomes.org/id/BAE78057 EnsemblBacteria BAE78057 http://www.ensemblgenomes.org/id/BAE78057 EnsemblBacteria BAE78057 http://www.ensemblgenomes.org/id/BAE78057 EnsemblBacteria b4055 http://www.ensemblgenomes.org/id/b4055 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0003993 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003993 GO_function GO:0004647 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004647 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0048037 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048037 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.1000 http://www.cathdb.info/version/latest/superfamily/3.40.50.1000 GeneID 948562 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948562 HOGENOM HOG000270623 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000270623&db=HOGENOM6 IntAct P0AE22 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AE22* IntEnz 3.1.3.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.2 InterPro IPR005519 http://www.ebi.ac.uk/interpro/entry/IPR005519 InterPro IPR010025 http://www.ebi.ac.uk/interpro/entry/IPR010025 InterPro IPR023214 http://www.ebi.ac.uk/interpro/entry/IPR023214 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4015 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4015 KEGG_Gene eco:b4055 http://www.genome.jp/dbget-bin/www_bget?eco:b4055 KEGG_Orthology KO:K03788 http://www.genome.jp/dbget-bin/www_bget?KO:K03788 KEGG_Pathway ko00627 http://www.genome.jp/kegg-bin/show_pathway?ko00627 KEGG_Pathway ko00740 http://www.genome.jp/kegg-bin/show_pathway?ko00740 KEGG_Reaction rn:R00548 http://www.genome.jp/dbget-bin/www_bget?rn:R00548 KEGG_Reaction rn:R03024 http://www.genome.jp/dbget-bin/www_bget?rn:R03024 MINT MINT-1294190 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1294190 OMA PEFWEKM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PEFWEKM PDB 1N8N http://www.ebi.ac.uk/pdbe-srv/view/entry/1N8N PDB 1N9K http://www.ebi.ac.uk/pdbe-srv/view/entry/1N9K PDB 1RMQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1RMQ PDB 1RMT http://www.ebi.ac.uk/pdbe-srv/view/entry/1RMT PDB 1RMY http://www.ebi.ac.uk/pdbe-srv/view/entry/1RMY PDB 2B82 http://www.ebi.ac.uk/pdbe-srv/view/entry/2B82 PDB 2B8J http://www.ebi.ac.uk/pdbe-srv/view/entry/2B8J PDB 2G1A http://www.ebi.ac.uk/pdbe-srv/view/entry/2G1A PDB 2HEG http://www.ebi.ac.uk/pdbe-srv/view/entry/2HEG PDB 2HF7 http://www.ebi.ac.uk/pdbe-srv/view/entry/2HF7 PDB 3CZ4 http://www.ebi.ac.uk/pdbe-srv/view/entry/3CZ4 PDBsum 1N8N http://www.ebi.ac.uk/pdbsum/1N8N PDBsum 1N9K http://www.ebi.ac.uk/pdbsum/1N9K PDBsum 1RMQ http://www.ebi.ac.uk/pdbsum/1RMQ PDBsum 1RMT http://www.ebi.ac.uk/pdbsum/1RMT PDBsum 1RMY http://www.ebi.ac.uk/pdbsum/1RMY PDBsum 2B82 http://www.ebi.ac.uk/pdbsum/2B82 PDBsum 2B8J http://www.ebi.ac.uk/pdbsum/2B8J PDBsum 2G1A http://www.ebi.ac.uk/pdbsum/2G1A PDBsum 2HEG http://www.ebi.ac.uk/pdbsum/2HEG PDBsum 2HF7 http://www.ebi.ac.uk/pdbsum/2HF7 PDBsum 3CZ4 http://www.ebi.ac.uk/pdbsum/3CZ4 PSORT swissprot:APHA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:APHA_ECOLI PSORT-B swissprot:APHA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:APHA_ECOLI PSORT2 swissprot:APHA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:APHA_ECOLI Pfam PF03767 http://pfam.xfam.org/family/PF03767 Phobius swissprot:APHA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:APHA_ECOLI ProteinModelPortal P0AE22 http://www.proteinmodelportal.org/query/uniprot/P0AE22 PubMed 12777773 http://www.ncbi.nlm.nih.gov/pubmed/12777773 PubMed 14687572 http://www.ncbi.nlm.nih.gov/pubmed/14687572 PubMed 16297670 http://www.ncbi.nlm.nih.gov/pubmed/16297670 PubMed 16330049 http://www.ncbi.nlm.nih.gov/pubmed/16330049 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18845157 http://www.ncbi.nlm.nih.gov/pubmed/18845157 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9011040 http://www.ncbi.nlm.nih.gov/pubmed/9011040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_418479 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418479 RefSeq WP_001226928 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001226928 SMR P0AE22 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AE22 STRING 511145.b4055 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4055&targetmode=cogs STRING COG3700 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3700&targetmode=cogs SUPFAM SSF56784 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784 TIGRFAMs TIGR01672 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01672 UniProtKB APHA_ECOLI http://www.uniprot.org/uniprot/APHA_ECOLI UniProtKB-AC P0AE22 http://www.uniprot.org/uniprot/P0AE22 charge swissprot:APHA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:APHA_ECOLI eggNOG COG3700 http://eggnogapi.embl.de/nog_data/html/tree/COG3700 eggNOG ENOG4105F0S http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F0S epestfind swissprot:APHA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:APHA_ECOLI garnier swissprot:APHA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:APHA_ECOLI helixturnhelix swissprot:APHA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:APHA_ECOLI hmoment swissprot:APHA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:APHA_ECOLI iep swissprot:APHA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:APHA_ECOLI inforesidue swissprot:APHA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:APHA_ECOLI octanol swissprot:APHA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:APHA_ECOLI pepcoil swissprot:APHA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:APHA_ECOLI pepdigest swissprot:APHA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:APHA_ECOLI pepinfo swissprot:APHA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:APHA_ECOLI pepnet swissprot:APHA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:APHA_ECOLI pepstats swissprot:APHA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:APHA_ECOLI pepwheel swissprot:APHA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:APHA_ECOLI pepwindow swissprot:APHA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:APHA_ECOLI sigcleave swissprot:APHA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:APHA_ECOLI ## Database ID URL or Descriptions # FUNCTION TRAS1_ECOLI Involved in surface exclusion. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_process GO:0000746 conjugation; IEA:UniProtKB-KW. # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0008150 biological_process # INDUCTION TRAS1_ECOLI The expression is positively controlled by the product of TraJ. # Organism TRAS1_ECOLI Escherichia coli (strain K12) # PIR S01756 S01756 # RecName TRAS1_ECOLI Protein TraS # RefSeq NP_061479 NC_002483.1 # RefSeq WP_000632670 NC_002483.1 # SUBCELLULAR LOCATION TRAS1_ECOLI Cell inner membrane. BLAST swissprot:TRAS1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRAS1_ECOLI DOI 10.1007/BF00299147 http://dx.doi.org/10.1007/BF00299147 DOI 10.1016/0022-2836(87)90452-9 http://dx.doi.org/10.1016/0022-2836(87)90452-9 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL M59763 http://www.ebi.ac.uk/ena/data/view/M59763 EMBL U01159 http://www.ebi.ac.uk/ena/data/view/U01159 EMBL X06915 http://www.ebi.ac.uk/ena/data/view/X06915 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_process GO:0000746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000746 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 1263588 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263588 OMA MITHYDI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MITHYDI PSORT swissprot:TRAS1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRAS1_ECOLI PSORT-B swissprot:TRAS1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRAS1_ECOLI PSORT2 swissprot:TRAS1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRAS1_ECOLI Phobius swissprot:TRAS1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRAS1_ECOLI ProteinModelPortal P09129 http://www.proteinmodelportal.org/query/uniprot/P09129 PubMed 1348105 http://www.ncbi.nlm.nih.gov/pubmed/1348105 PubMed 3323526 http://www.ncbi.nlm.nih.gov/pubmed/3323526 PubMed 7915817 http://www.ncbi.nlm.nih.gov/pubmed/7915817 RefSeq NP_061479 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061479 RefSeq WP_000632670 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000632670 UniProtKB TRAS1_ECOLI http://www.uniprot.org/uniprot/TRAS1_ECOLI UniProtKB-AC P09129 http://www.uniprot.org/uniprot/P09129 charge swissprot:TRAS1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRAS1_ECOLI epestfind swissprot:TRAS1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRAS1_ECOLI garnier swissprot:TRAS1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRAS1_ECOLI helixturnhelix swissprot:TRAS1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRAS1_ECOLI hmoment swissprot:TRAS1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRAS1_ECOLI iep swissprot:TRAS1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRAS1_ECOLI inforesidue swissprot:TRAS1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRAS1_ECOLI octanol swissprot:TRAS1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRAS1_ECOLI pepcoil swissprot:TRAS1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRAS1_ECOLI pepdigest swissprot:TRAS1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRAS1_ECOLI pepinfo swissprot:TRAS1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRAS1_ECOLI pepnet swissprot:TRAS1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRAS1_ECOLI pepstats swissprot:TRAS1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRAS1_ECOLI pepwheel swissprot:TRAS1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRAS1_ECOLI pepwindow swissprot:TRAS1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRAS1_ECOLI sigcleave swissprot:TRAS1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRAS1_ECOLI ## Database ID URL or Descriptions # Organism YUBG_ECOLI Escherichia coli (strain K12) # RecName YUBG_ECOLI Uncharacterized protein YubG # RefSeq NP_061434 NC_002483.1 # RefSeq WP_001005032 NZ_CP014273.1 BLAST swissprot:YUBG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YUBG_ECOLI DOI 10.1006/plas.1999.1390 http://dx.doi.org/10.1006/plas.1999.1390 EMBL AF106329 http://www.ebi.ac.uk/ena/data/view/AF106329 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1263492 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263492 OMA RTETIMM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RTETIMM PSORT swissprot:YUBG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YUBG_ECOLI PSORT-B swissprot:YUBG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YUBG_ECOLI PSORT2 swissprot:YUBG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YUBG_ECOLI Phobius swissprot:YUBG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YUBG_ECOLI ProteinModelPortal Q9S4W9 http://www.proteinmodelportal.org/query/uniprot/Q9S4W9 PubMed 10366527 http://www.ncbi.nlm.nih.gov/pubmed/10366527 RefSeq NP_061434 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061434 RefSeq WP_001005032 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001005032 SMR Q9S4W9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9S4W9 UniProtKB YUBG_ECOLI http://www.uniprot.org/uniprot/YUBG_ECOLI UniProtKB-AC Q9S4W9 http://www.uniprot.org/uniprot/Q9S4W9 charge swissprot:YUBG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YUBG_ECOLI epestfind swissprot:YUBG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YUBG_ECOLI garnier swissprot:YUBG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YUBG_ECOLI helixturnhelix swissprot:YUBG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YUBG_ECOLI hmoment swissprot:YUBG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YUBG_ECOLI iep swissprot:YUBG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YUBG_ECOLI inforesidue swissprot:YUBG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YUBG_ECOLI octanol swissprot:YUBG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YUBG_ECOLI pepcoil swissprot:YUBG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YUBG_ECOLI pepdigest swissprot:YUBG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YUBG_ECOLI pepinfo swissprot:YUBG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YUBG_ECOLI pepnet swissprot:YUBG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YUBG_ECOLI pepstats swissprot:YUBG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YUBG_ECOLI pepwheel swissprot:YUBG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YUBG_ECOLI pepwindow swissprot:YUBG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YUBG_ECOLI sigcleave swissprot:YUBG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YUBG_ECOLI ## Database ID URL or Descriptions # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # InterPro IPR007159 SpoVT-AbrB_dom # Organism YPFU_ECOLI Escherichia coli (strain K12) # PIR JS0295 Q4ECTI # PROSITE PS51740 SPOVT_ABRB # Pfam PF04014 MazE_antitoxin # RecName YPFU_ECOLI Uncharacterized protein in traD-traI intergenic region # RefSeq WP_000450532 NZ_CP014273.1 # SIMILARITY Belongs to the VapB family. {ECO 0000305}. # SIMILARITY Contains 1 SpoVT-AbrB domain. {ECO:0000255|PROSITE- ProRule PRU01076}. BLAST swissprot:YPFU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YPFU_ECOLI DOI 10.1016/0378-1119(89)90179-0 http://dx.doi.org/10.1016/0378-1119(89)90179-0 EMBL M29254 http://www.ebi.ac.uk/ena/data/view/M29254 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 InterPro IPR007159 http://www.ebi.ac.uk/interpro/entry/IPR007159 PROSITE PS51740 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51740 PSORT swissprot:YPFU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YPFU_ECOLI PSORT-B swissprot:YPFU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YPFU_ECOLI PSORT2 swissprot:YPFU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YPFU_ECOLI Pfam PF04014 http://pfam.xfam.org/family/PF04014 Phobius swissprot:YPFU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YPFU_ECOLI ProteinModelPortal P18355 http://www.proteinmodelportal.org/query/uniprot/P18355 PubMed 2680768 http://www.ncbi.nlm.nih.gov/pubmed/2680768 RefSeq WP_000450532 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000450532 SMR P18355 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P18355 UniProtKB YPFU_ECOLI http://www.uniprot.org/uniprot/YPFU_ECOLI UniProtKB-AC P18355 http://www.uniprot.org/uniprot/P18355 charge swissprot:YPFU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YPFU_ECOLI epestfind swissprot:YPFU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YPFU_ECOLI garnier swissprot:YPFU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YPFU_ECOLI helixturnhelix swissprot:YPFU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YPFU_ECOLI hmoment swissprot:YPFU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YPFU_ECOLI iep swissprot:YPFU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YPFU_ECOLI inforesidue swissprot:YPFU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YPFU_ECOLI octanol swissprot:YPFU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YPFU_ECOLI pepcoil swissprot:YPFU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YPFU_ECOLI pepdigest swissprot:YPFU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YPFU_ECOLI pepinfo swissprot:YPFU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YPFU_ECOLI pepnet swissprot:YPFU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YPFU_ECOLI pepstats swissprot:YPFU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YPFU_ECOLI pepwheel swissprot:YPFU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YPFU_ECOLI pepwindow swissprot:YPFU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YPFU_ECOLI sigcleave swissprot:YPFU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YPFU_ECOLI ## Database ID URL or Descriptions # BioGrid 4259794 22 # EcoGene EG14325 ykgL # Organism YKGL_ECOLI Escherichia coli (strain K12) # PIR G64755 G64755 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YKGL_ECOLI Uncharacterized protein YkgL # RefSeq NP_414829 NC_000913.3 # RefSeq WP_001147279 NZ_LN832404.1 BLAST swissprot:YKGL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YKGL_ECOLI BioCyc ECOL316407:JW5033-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5033-MONOMER BioCyc EcoCyc:G6166-MONOMER http://biocyc.org/getid?id=EcoCyc:G6166-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4071 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4071 EcoGene EG14325 http://www.ecogene.org/geneInfo.php?eg_id=EG14325 EnsemblBacteria AAC73398 http://www.ensemblgenomes.org/id/AAC73398 EnsemblBacteria AAC73398 http://www.ensemblgenomes.org/id/AAC73398 EnsemblBacteria BAE76079 http://www.ensemblgenomes.org/id/BAE76079 EnsemblBacteria BAE76079 http://www.ensemblgenomes.org/id/BAE76079 EnsemblBacteria BAE76079 http://www.ensemblgenomes.org/id/BAE76079 EnsemblBacteria b0295 http://www.ensemblgenomes.org/id/b0295 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 944962 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944962 HOGENOM HOG000054879 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000054879&db=HOGENOM6 KEGG_Gene ecj:JW5033 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5033 KEGG_Gene eco:b0295 http://www.genome.jp/dbget-bin/www_bget?eco:b0295 PSORT swissprot:YKGL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YKGL_ECOLI PSORT-B swissprot:YKGL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YKGL_ECOLI PSORT2 swissprot:YKGL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YKGL_ECOLI Phobius swissprot:YKGL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YKGL_ECOLI ProteinModelPortal P56257 http://www.proteinmodelportal.org/query/uniprot/P56257 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414829 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414829 RefSeq WP_001147279 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001147279 STRING 511145.b0295 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0295&targetmode=cogs UniProtKB YKGL_ECOLI http://www.uniprot.org/uniprot/YKGL_ECOLI UniProtKB-AC P56257 http://www.uniprot.org/uniprot/P56257 charge swissprot:YKGL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YKGL_ECOLI epestfind swissprot:YKGL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YKGL_ECOLI garnier swissprot:YKGL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YKGL_ECOLI helixturnhelix swissprot:YKGL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YKGL_ECOLI hmoment swissprot:YKGL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YKGL_ECOLI iep swissprot:YKGL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YKGL_ECOLI inforesidue swissprot:YKGL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YKGL_ECOLI octanol swissprot:YKGL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YKGL_ECOLI pepcoil swissprot:YKGL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YKGL_ECOLI pepdigest swissprot:YKGL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YKGL_ECOLI pepinfo swissprot:YKGL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YKGL_ECOLI pepnet swissprot:YKGL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YKGL_ECOLI pepstats swissprot:YKGL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YKGL_ECOLI pepwheel swissprot:YKGL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YKGL_ECOLI pepwindow swissprot:YKGL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YKGL_ECOLI sigcleave swissprot:YKGL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YKGL_ECOLI ## Database ID URL or Descriptions # BioGrid 4261842 133 # EcoGene EG13665 ybhI # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IBA:GO_Central. # GO_function GO:0005215 transporter activity; IBA:GO_Central. # GO_process GO:0006814 sodium ion transport; IEA:InterPro. # GO_process GO:0098656 anion transmembrane transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # InterPro IPR001898 Na/sul_symport # InterPro IPR030676 CitT-rel # Organism YBHI_ECOLI Escherichia coli (strain K12) # PATRIC 32116741 VBIEscCol129921_0796 # PIR B64813 B64813 # PIRSF PIRSF002457 DASS # Pfam PF00939 Na_sulph_symp # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBHI_ECOLI Inner membrane protein YbhI # RefSeq NP_415291 NC_000913.3 # RefSeq WP_001036475 NZ_LN832404.1 # SIMILARITY Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. DIT1 subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION YBHI_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.47.3:the divalent anion na(+) symporter (dass) family # TIGRFAMs TIGR00785 dass # eggNOG COG0471 LUCA # eggNOG ENOG4107QPK Bacteria BLAST swissprot:YBHI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBHI_ECOLI BioCyc ECOL316407:JW0753-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0753-MONOMER BioCyc EcoCyc:B0770-MONOMER http://biocyc.org/getid?id=EcoCyc:B0770-MONOMER COG COG0471 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0471 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3429 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3429 EcoGene EG13665 http://www.ecogene.org/geneInfo.php?eg_id=EG13665 EnsemblBacteria AAC73857 http://www.ensemblgenomes.org/id/AAC73857 EnsemblBacteria AAC73857 http://www.ensemblgenomes.org/id/AAC73857 EnsemblBacteria BAA35434 http://www.ensemblgenomes.org/id/BAA35434 EnsemblBacteria BAA35434 http://www.ensemblgenomes.org/id/BAA35434 EnsemblBacteria BAA35434 http://www.ensemblgenomes.org/id/BAA35434 EnsemblBacteria b0770 http://www.ensemblgenomes.org/id/b0770 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_process GO:0006814 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814 GO_process GO:0098656 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098656 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 945377 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945377 HOGENOM HOG000117912 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117912&db=HOGENOM6 InParanoid P75763 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75763 InterPro IPR001898 http://www.ebi.ac.uk/interpro/entry/IPR001898 InterPro IPR030676 http://www.ebi.ac.uk/interpro/entry/IPR030676 KEGG_Gene ecj:JW0753 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0753 KEGG_Gene eco:b0770 http://www.genome.jp/dbget-bin/www_bget?eco:b0770 KEGG_Orthology KO:K03319 http://www.genome.jp/dbget-bin/www_bget?KO:K03319 OMA TSAMFVT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TSAMFVT PSORT swissprot:YBHI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBHI_ECOLI PSORT-B swissprot:YBHI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBHI_ECOLI PSORT2 swissprot:YBHI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBHI_ECOLI Pfam PF00939 http://pfam.xfam.org/family/PF00939 Phobius swissprot:YBHI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBHI_ECOLI PhylomeDB P75763 http://phylomedb.org/?seqid=P75763 ProteinModelPortal P75763 http://www.proteinmodelportal.org/query/uniprot/P75763 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415291 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415291 RefSeq WP_001036475 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001036475 STRING 511145.b0770 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0770&targetmode=cogs STRING COG0471 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0471&targetmode=cogs TCDB 2.A.47.3 http://www.tcdb.org/search/result.php?tc=2.A.47.3 TIGRFAMs TIGR00785 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00785 UniProtKB YBHI_ECOLI http://www.uniprot.org/uniprot/YBHI_ECOLI UniProtKB-AC P75763 http://www.uniprot.org/uniprot/P75763 charge swissprot:YBHI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBHI_ECOLI eggNOG COG0471 http://eggnogapi.embl.de/nog_data/html/tree/COG0471 eggNOG ENOG4107QPK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QPK epestfind swissprot:YBHI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBHI_ECOLI garnier swissprot:YBHI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBHI_ECOLI helixturnhelix swissprot:YBHI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBHI_ECOLI hmoment swissprot:YBHI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBHI_ECOLI iep swissprot:YBHI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBHI_ECOLI inforesidue swissprot:YBHI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBHI_ECOLI octanol swissprot:YBHI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBHI_ECOLI pepcoil swissprot:YBHI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBHI_ECOLI pepdigest swissprot:YBHI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBHI_ECOLI pepinfo swissprot:YBHI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBHI_ECOLI pepnet swissprot:YBHI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBHI_ECOLI pepstats swissprot:YBHI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBHI_ECOLI pepwheel swissprot:YBHI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBHI_ECOLI pepwindow swissprot:YBHI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBHI_ECOLI sigcleave swissprot:YBHI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBHI_ECOLI ## Database ID URL or Descriptions # AltName Carbamoyl-phosphate synthetase ammonia chain {ECO:0000255|HAMAP-Rule MF_01210} # BRENDA 6.3.5 2026 # BioGrid 4259726 22 # CATALYTIC ACTIVITY 2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate. {ECO:0000255|HAMAP-Rule MF_01210}. # CDD cd01424 MGS_CPS_II # COFACTOR CARB_ECOLI Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000255|HAMAP-Rule MF_01210}; Note=Binds 4 Mn(2+) ions per subunit. {ECO 0000255|HAMAP- Rule MF_01210}; # EcoGene EG10135 carB # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005951 carbamoyl-phosphate synthase complex; IDA:EcoCyc. # GO_function GO:0000166 nucleotide binding; IDA:EcoliWiki. # GO_function GO:0004087 carbamoyl-phosphate synthase (ammonia) activity; IDA:EcoliWiki. # GO_function GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; IEA:UniProtKB-EC. # GO_function GO:0005524 ATP binding; IDA:EcoCyc. # GO_function GO:0016597 amino acid binding; IDA:EcoliWiki. # GO_function GO:0046872 metal ion binding; IDA:EcoliWiki. # GO_process GO:0000050 urea cycle; IBA:GO_Central. # GO_process GO:0006526 arginine biosynthetic process; IBA:GO_Central. # GO_process GO:0008652 cellular amino acid biosynthetic process; IMP:EcoliWiki. # GO_process GO:0019856 pyrimidine nucleobase biosynthetic process; IMP:EcoliWiki. # GO_process GO:0044205 'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0071941 nitrogen cycle metabolic process # Gene3D 1.10.1030.10 -; 1. # Gene3D 3.30.1490.20 -; 2. # Gene3D 3.30.470.20 -; 2. # Gene3D 3.40.50.1380 -; 1. # Gene3D 3.40.50.20 -; 2. # HAMAP MF_01210_A CPSase_L_chain_A # HAMAP MF_01210_B CPSase_L_chain_B # INTERACTION CARB_ECOLI P0A6F1 carA; NbExp=11; IntAct=EBI-546118, EBI-546107; # IntAct P00968 13 # InterPro IPR005479 CbamoylP_synth_lsu-like_ATP-bd # InterPro IPR005480 CarbamoylP_synth_lsu_oligo # InterPro IPR005483 CbamoylP_synth_lsu_CPSase_dom # InterPro IPR006275 CarbamoylP_synth_lsu # InterPro IPR011607 MGS-like_dom # InterPro IPR011761 ATP-grasp # InterPro IPR013815 ATP_grasp_subdomain_1 # InterPro IPR013816 ATP_grasp_subdomain_2 # InterPro IPR016185 PreATP-grasp_dom # InterPro IPR033937 MGS_CPS_CarB # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00240 Pyrimidine metabolism # KEGG_Pathway ko00250 Alanine, aspartate and glutamate metabolism # Organism CARB_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1. {ECO 0000255|HAMAP-Rule:MF_01210}. # PATHWAY Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3. {ECO 0000255|HAMAP-Rule:MF_01210}. # PATRIC 32115159 VBIEscCol129921_0031 # PDB 1A9X X-ray; 1.80 A; A/C/E/G=1-1073 # PDB 1BXR X-ray; 2.10 A; A/C/E/G=1-1073 # PDB 1C30 X-ray; 2.00 A; A/C/E/G=1-1073 # PDB 1C3O X-ray; 2.10 A; A/C/E/G=1-1073 # PDB 1CE8 X-ray; 2.10 A; A/C/E/G=1-1073 # PDB 1CS0 X-ray; 2.00 A; A/C/E/G=1-1073 # PDB 1JDB X-ray; 2.10 A; B/E/H/K=1-1073 # PDB 1KEE X-ray; 2.10 A; A/C/E/G=1-1073 # PDB 1M6V X-ray; 2.10 A; A/C/E/G=1-1073 # PDB 1T36 X-ray; 2.10 A; A/C/E/G=1-1073 # PIR A01198 SYECCP # PRINTS PR00098 CPSASE # PROSITE PS00866 CPSASE_1; 2 # PROSITE PS00867 CPSASE_2; 2 # PROSITE PS50975 ATP_GRASP; 2 # Pfam PF02142 MGS # Pfam PF02786 CPSase_L_D2; 2 # Pfam PF02787 CPSase_L_D3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Carbamoyl-phosphate synthase large chain {ECO:0000255|HAMAP-Rule MF_01210} # RefSeq NP_414574 NC_000913.3 # RefSeq WP_001126348 NZ_LN832404.1 # SIMILARITY Belongs to the CarB family. {ECO:0000255|HAMAP- Rule MF_01210}. # SIMILARITY Contains 2 ATP-grasp domains. {ECO:0000255|HAMAP- Rule MF_01210}. # SMART SM00851 MGS # SMART SM01096 CPSase_L_D3 # SUBUNIT Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. Tetramer of heterodimers (alpha,beta)4. {ECO:0000255|HAMAP- Rule MF_01210}. # SUPFAM SSF48108 SSF48108 # SUPFAM SSF52335 SSF52335 # SUPFAM SSF52440 SSF52440; 2 # TIGRFAMs TIGR01369 CPSaseII_lrg # UniPathway UPA00068 UER00171 # UniPathway UPA00070 UER00115 # eggNOG COG0458 LUCA # eggNOG ENOG4105CU6 Bacteria BLAST swissprot:CARB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CARB_ECOLI BioCyc ECOL316407:JW0031-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0031-MONOMER BioCyc EcoCyc:CARBPSYN-LARGE http://biocyc.org/getid?id=EcoCyc:CARBPSYN-LARGE BioCyc MetaCyc:CARBPSYN-LARGE http://biocyc.org/getid?id=MetaCyc:CARBPSYN-LARGE COG COG0458 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0458 DIP DIP-1025N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-1025N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1021/bi970503q http://dx.doi.org/10.1021/bi970503q DOI 10.1021/bi9807761 http://dx.doi.org/10.1021/bi9807761 DOI 10.1021/bi982517h http://dx.doi.org/10.1021/bi982517h DOI 10.1021/bi991741j http://dx.doi.org/10.1021/bi991741j DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.80.15.4629 http://dx.doi.org/10.1073/pnas.80.15.4629 DOI 10.1073/pnas.81.13.4134 http://dx.doi.org/10.1073/pnas.81.13.4134 DOI 10.1073/pnas.81.13.4139 http://dx.doi.org/10.1073/pnas.81.13.4139 DOI 10.1074/jbc.274.32.22502 http://dx.doi.org/10.1074/jbc.274.32.22502 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1107/S0907444998006234 http://dx.doi.org/10.1107/S0907444998006234 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.3.5.5 {ECO:0000255|HAMAP-Rule:MF_01210} http://www.genome.jp/dbget-bin/www_bget?EC:6.3.5.5 {ECO:0000255|HAMAP-Rule:MF_01210} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01597 http://www.ebi.ac.uk/ena/data/view/J01597 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V01500 http://www.ebi.ac.uk/ena/data/view/V01500 ENZYME 6.3.5.5 {ECO:0000255|HAMAP-Rule:MF_01210} http://enzyme.expasy.org/EC/6.3.5.5 {ECO:0000255|HAMAP-Rule:MF_01210} EchoBASE EB0133 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0133 EcoGene EG10135 http://www.ecogene.org/geneInfo.php?eg_id=EG10135 EnsemblBacteria AAC73144 http://www.ensemblgenomes.org/id/AAC73144 EnsemblBacteria AAC73144 http://www.ensemblgenomes.org/id/AAC73144 EnsemblBacteria BAB96602 http://www.ensemblgenomes.org/id/BAB96602 EnsemblBacteria BAB96602 http://www.ensemblgenomes.org/id/BAB96602 EnsemblBacteria BAB96602 http://www.ensemblgenomes.org/id/BAB96602 EnsemblBacteria b0033 http://www.ensemblgenomes.org/id/b0033 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005951 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005951 GO_function GO:0000166 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000166 GO_function GO:0004087 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004087 GO_function GO:0004088 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004088 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016597 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0000050 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000050 GO_process GO:0006526 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006526 GO_process GO:0008652 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008652 GO_process GO:0019856 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019856 GO_process GO:0044205 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044205 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0071941 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071941 Gene3D 1.10.1030.10 http://www.cathdb.info/version/latest/superfamily/1.10.1030.10 Gene3D 3.30.1490.20 http://www.cathdb.info/version/latest/superfamily/3.30.1490.20 Gene3D 3.30.470.20 http://www.cathdb.info/version/latest/superfamily/3.30.470.20 Gene3D 3.40.50.1380 http://www.cathdb.info/version/latest/superfamily/3.40.50.1380 Gene3D 3.40.50.20 http://www.cathdb.info/version/latest/superfamily/3.40.50.20 GeneID 944775 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944775 HAMAP MF_01210_A http://hamap.expasy.org/unirule/MF_01210_A HAMAP MF_01210_B http://hamap.expasy.org/unirule/MF_01210_B HOGENOM HOG000234582 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000234582&db=HOGENOM6 InParanoid P00968 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00968 IntAct P00968 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00968* IntEnz 6.3.5.5 {ECO:0000255|HAMAP-Rule:MF_01210} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.5.5 {ECO:0000255|HAMAP-Rule:MF_01210} InterPro IPR005479 http://www.ebi.ac.uk/interpro/entry/IPR005479 InterPro IPR005480 http://www.ebi.ac.uk/interpro/entry/IPR005480 InterPro IPR005483 http://www.ebi.ac.uk/interpro/entry/IPR005483 InterPro IPR006275 http://www.ebi.ac.uk/interpro/entry/IPR006275 InterPro IPR011607 http://www.ebi.ac.uk/interpro/entry/IPR011607 InterPro IPR011761 http://www.ebi.ac.uk/interpro/entry/IPR011761 InterPro IPR013815 http://www.ebi.ac.uk/interpro/entry/IPR013815 InterPro IPR013816 http://www.ebi.ac.uk/interpro/entry/IPR013816 InterPro IPR016185 http://www.ebi.ac.uk/interpro/entry/IPR016185 InterPro IPR033937 http://www.ebi.ac.uk/interpro/entry/IPR033937 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0031 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0031 KEGG_Gene eco:b0033 http://www.genome.jp/dbget-bin/www_bget?eco:b0033 KEGG_Orthology KO:K01955 http://www.genome.jp/dbget-bin/www_bget?KO:K01955 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Pathway ko00250 http://www.genome.jp/kegg-bin/show_pathway?ko00250 KEGG_Reaction rn:R00575 http://www.genome.jp/dbget-bin/www_bget?rn:R00575 MINT MINT-1255866 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1255866 OMA STAYMYS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=STAYMYS PDB 1A9X http://www.ebi.ac.uk/pdbe-srv/view/entry/1A9X PDB 1BXR http://www.ebi.ac.uk/pdbe-srv/view/entry/1BXR PDB 1C30 http://www.ebi.ac.uk/pdbe-srv/view/entry/1C30 PDB 1C3O http://www.ebi.ac.uk/pdbe-srv/view/entry/1C3O PDB 1CE8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1CE8 PDB 1CS0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1CS0 PDB 1JDB http://www.ebi.ac.uk/pdbe-srv/view/entry/1JDB PDB 1KEE http://www.ebi.ac.uk/pdbe-srv/view/entry/1KEE PDB 1M6V http://www.ebi.ac.uk/pdbe-srv/view/entry/1M6V PDB 1T36 http://www.ebi.ac.uk/pdbe-srv/view/entry/1T36 PDBsum 1A9X http://www.ebi.ac.uk/pdbsum/1A9X PDBsum 1BXR http://www.ebi.ac.uk/pdbsum/1BXR PDBsum 1C30 http://www.ebi.ac.uk/pdbsum/1C30 PDBsum 1C3O http://www.ebi.ac.uk/pdbsum/1C3O PDBsum 1CE8 http://www.ebi.ac.uk/pdbsum/1CE8 PDBsum 1CS0 http://www.ebi.ac.uk/pdbsum/1CS0 PDBsum 1JDB http://www.ebi.ac.uk/pdbsum/1JDB PDBsum 1KEE http://www.ebi.ac.uk/pdbsum/1KEE PDBsum 1M6V http://www.ebi.ac.uk/pdbsum/1M6V PDBsum 1T36 http://www.ebi.ac.uk/pdbsum/1T36 PRINTS PR00098 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00098 PROSITE PS00866 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00866 PROSITE PS00867 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00867 PROSITE PS50975 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50975 PSORT swissprot:CARB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CARB_ECOLI PSORT-B swissprot:CARB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CARB_ECOLI PSORT2 swissprot:CARB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CARB_ECOLI Pfam PF02142 http://pfam.xfam.org/family/PF02142 Pfam PF02786 http://pfam.xfam.org/family/PF02786 Pfam PF02787 http://pfam.xfam.org/family/PF02787 Phobius swissprot:CARB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CARB_ECOLI PhylomeDB P00968 http://phylomedb.org/?seqid=P00968 ProteinModelPortal P00968 http://www.proteinmodelportal.org/query/uniprot/P00968 PubMed 10029528 http://www.ncbi.nlm.nih.gov/pubmed/10029528 PubMed 10089390 http://www.ncbi.nlm.nih.gov/pubmed/10089390 PubMed 10428826 http://www.ncbi.nlm.nih.gov/pubmed/10428826 PubMed 10587438 http://www.ncbi.nlm.nih.gov/pubmed/10587438 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6308632 http://www.ncbi.nlm.nih.gov/pubmed/6308632 PubMed 6330744 http://www.ncbi.nlm.nih.gov/pubmed/6330744 PubMed 6377309 http://www.ncbi.nlm.nih.gov/pubmed/6377309 PubMed 9174345 http://www.ncbi.nlm.nih.gov/pubmed/9174345 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9636022 http://www.ncbi.nlm.nih.gov/pubmed/9636022 RefSeq NP_414574 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414574 RefSeq WP_001126348 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001126348 SMART SM00851 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00851 SMART SM01096 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01096 SMR P00968 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00968 STRING 511145.b0033 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0033&targetmode=cogs STRING COG0458 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0458&targetmode=cogs SUPFAM SSF48108 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48108 SUPFAM SSF52335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52335 SUPFAM SSF52440 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52440 TIGRFAMs TIGR01369 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01369 UniProtKB CARB_ECOLI http://www.uniprot.org/uniprot/CARB_ECOLI UniProtKB-AC P00968 http://www.uniprot.org/uniprot/P00968 charge swissprot:CARB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CARB_ECOLI eggNOG COG0458 http://eggnogapi.embl.de/nog_data/html/tree/COG0458 eggNOG ENOG4105CU6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CU6 epestfind swissprot:CARB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CARB_ECOLI garnier swissprot:CARB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CARB_ECOLI helixturnhelix swissprot:CARB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CARB_ECOLI hmoment swissprot:CARB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CARB_ECOLI iep swissprot:CARB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CARB_ECOLI inforesidue swissprot:CARB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CARB_ECOLI octanol swissprot:CARB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CARB_ECOLI pepcoil swissprot:CARB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CARB_ECOLI pepdigest swissprot:CARB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CARB_ECOLI pepinfo swissprot:CARB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CARB_ECOLI pepnet swissprot:CARB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CARB_ECOLI pepstats swissprot:CARB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CARB_ECOLI pepwheel swissprot:CARB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CARB_ECOLI pepwindow swissprot:CARB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CARB_ECOLI sigcleave swissprot:CARB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CARB_ECOLI ## Database ID URL or Descriptions # BioGrid 4262772 15 # EcoGene EG12585 yjiX # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_process GO:0006950 response to stress # InterPro IPR007423 Sel_put # Organism YJIX_ECOLI Escherichia coli (strain K12) # PATRIC 32124312 VBIEscCol129921_4499 # PIR S56579 S56579 # Pfam PF04328 Sel_put # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJIX_ECOLI Uncharacterized protein YjiX # RefSeq NP_418773 NC_000913.3 # RefSeq WP_000467859 NZ_LN832404.1 # SIMILARITY To E.coli YbdD. {ECO 0000305}. # eggNOG COG2879 LUCA # eggNOG ENOG4105VCD Bacteria BLAST swissprot:YJIX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJIX_ECOLI BioCyc ECOL316407:JW4316-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4316-MONOMER BioCyc EcoCyc:G7941-MONOMER http://biocyc.org/getid?id=EcoCyc:G7941-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2471 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2471 EcoGene EG12585 http://www.ecogene.org/geneInfo.php?eg_id=EG12585 EnsemblBacteria AAC77309 http://www.ensemblgenomes.org/id/AAC77309 EnsemblBacteria AAC77309 http://www.ensemblgenomes.org/id/AAC77309 EnsemblBacteria BAE78343 http://www.ensemblgenomes.org/id/BAE78343 EnsemblBacteria BAE78343 http://www.ensemblgenomes.org/id/BAE78343 EnsemblBacteria BAE78343 http://www.ensemblgenomes.org/id/BAE78343 EnsemblBacteria b4353 http://www.ensemblgenomes.org/id/b4353 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 949090 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949090 HOGENOM HOG000239011 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000239011&db=HOGENOM6 InParanoid P0ADC8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADC8 IntAct P0ADC8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADC8* InterPro IPR007423 http://www.ebi.ac.uk/interpro/entry/IPR007423 KEGG_Gene ecj:JW4316 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4316 KEGG_Gene eco:b4353 http://www.genome.jp/dbget-bin/www_bget?eco:b4353 OMA QEARYGS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QEARYGS PSORT swissprot:YJIX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJIX_ECOLI PSORT-B swissprot:YJIX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJIX_ECOLI PSORT2 swissprot:YJIX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJIX_ECOLI Pfam PF04328 http://pfam.xfam.org/family/PF04328 Phobius swissprot:YJIX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJIX_ECOLI PhylomeDB P0ADC8 http://phylomedb.org/?seqid=P0ADC8 ProteinModelPortal P0ADC8 http://www.proteinmodelportal.org/query/uniprot/P0ADC8 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418773 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418773 RefSeq WP_000467859 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000467859 STRING 511145.b4353 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4353&targetmode=cogs UniProtKB YJIX_ECOLI http://www.uniprot.org/uniprot/YJIX_ECOLI UniProtKB-AC P0ADC8 http://www.uniprot.org/uniprot/P0ADC8 charge swissprot:YJIX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJIX_ECOLI eggNOG COG2879 http://eggnogapi.embl.de/nog_data/html/tree/COG2879 eggNOG ENOG4105VCD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VCD epestfind swissprot:YJIX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJIX_ECOLI garnier swissprot:YJIX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJIX_ECOLI helixturnhelix swissprot:YJIX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJIX_ECOLI hmoment swissprot:YJIX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJIX_ECOLI iep swissprot:YJIX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJIX_ECOLI inforesidue swissprot:YJIX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJIX_ECOLI octanol swissprot:YJIX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJIX_ECOLI pepcoil swissprot:YJIX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJIX_ECOLI pepdigest swissprot:YJIX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJIX_ECOLI pepinfo swissprot:YJIX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJIX_ECOLI pepnet swissprot:YJIX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJIX_ECOLI pepstats swissprot:YJIX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJIX_ECOLI pepwheel swissprot:YJIX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJIX_ECOLI pepwindow swissprot:YJIX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJIX_ECOLI sigcleave swissprot:YJIX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJIX_ECOLI ## Database ID URL or Descriptions # BioGrid 4262122 20 # EcoGene EG13148 yafK # GO_function GO:0016757 transferase activity, transferring glycosyl groups; IEA:UniProtKB-KW. # GO_function GO:0016787 hydrolase activity; IEA:UniProtKB-KW. # GO_process GO:0008360 regulation of cell shape; IEA:UniProtKB-KW. # GO_process GO:0009252 peptidoglycan biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0071554 cell wall organization or biogenesis # InterPro IPR005490 LD_TPept_cat_dom # Organism YAFK_ECOLI Escherichia coli (strain K12) # PATHWAY YAFK_ECOLI Cell wall biogenesis; peptidoglycan biosynthesis. # PATRIC 32115563 VBIEscCol129921_0226 # PIR A64747 A64747 # Pfam PF03734 YkuD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAFK_ECOLI Putative L,D-transpeptidase YafK # RefSeq NP_414759 NC_000913.3 # RefSeq WP_001225679 NZ_LN832404.1 # SIMILARITY Belongs to the YkuD family. {ECO 0000305}. # eggNOG COG3034 LUCA # eggNOG ENOG4105F7V Bacteria BLAST swissprot:YAFK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAFK_ECOLI BioCyc ECOL316407:JW0214-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0214-MONOMER BioCyc EcoCyc:G6108-MONOMER http://biocyc.org/getid?id=EcoCyc:G6108-MONOMER DOI 10.1016/0165-7992(95)90024-1 http://dx.doi.org/10.1016/0165-7992(95)90024-1 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:2.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D38582 http://www.ebi.ac.uk/ena/data/view/D38582 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 ENZYME 2.-.-.- http://enzyme.expasy.org/EC/2.-.-.- EchoBASE EB2942 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2942 EcoGene EG13148 http://www.ecogene.org/geneInfo.php?eg_id=EG13148 EnsemblBacteria AAC73328 http://www.ensemblgenomes.org/id/AAC73328 EnsemblBacteria AAC73328 http://www.ensemblgenomes.org/id/AAC73328 EnsemblBacteria BAA77894 http://www.ensemblgenomes.org/id/BAA77894 EnsemblBacteria BAA77894 http://www.ensemblgenomes.org/id/BAA77894 EnsemblBacteria BAA77894 http://www.ensemblgenomes.org/id/BAA77894 EnsemblBacteria b0224 http://www.ensemblgenomes.org/id/b0224 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GO_function GO:0016787 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016787 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0009252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009252 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 GeneID 944910 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944910 HOGENOM HOG000117032 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117032&db=HOGENOM6 InParanoid P0AA99 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AA99 IntEnz 2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2 InterPro IPR005490 http://www.ebi.ac.uk/interpro/entry/IPR005490 KEGG_Gene ecj:JW0214 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0214 KEGG_Gene eco:b0224 http://www.genome.jp/dbget-bin/www_bget?eco:b0224 OMA CYAMTDT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CYAMTDT PSORT swissprot:YAFK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAFK_ECOLI PSORT-B swissprot:YAFK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAFK_ECOLI PSORT2 swissprot:YAFK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAFK_ECOLI Pfam PF03734 http://pfam.xfam.org/family/PF03734 Phobius swissprot:YAFK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAFK_ECOLI PhylomeDB P0AA99 http://phylomedb.org/?seqid=P0AA99 ProteinModelPortal P0AA99 http://www.proteinmodelportal.org/query/uniprot/P0AA99 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7596361 http://www.ncbi.nlm.nih.gov/pubmed/7596361 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414759 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414759 RefSeq WP_001225679 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001225679 STRING 511145.b0224 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0224&targetmode=cogs UniProtKB YAFK_ECOLI http://www.uniprot.org/uniprot/YAFK_ECOLI UniProtKB-AC P0AA99 http://www.uniprot.org/uniprot/P0AA99 charge swissprot:YAFK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAFK_ECOLI eggNOG COG3034 http://eggnogapi.embl.de/nog_data/html/tree/COG3034 eggNOG ENOG4105F7V http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F7V epestfind swissprot:YAFK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAFK_ECOLI garnier swissprot:YAFK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAFK_ECOLI helixturnhelix swissprot:YAFK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAFK_ECOLI hmoment swissprot:YAFK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAFK_ECOLI iep swissprot:YAFK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAFK_ECOLI inforesidue swissprot:YAFK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAFK_ECOLI octanol swissprot:YAFK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAFK_ECOLI pepcoil swissprot:YAFK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAFK_ECOLI pepdigest swissprot:YAFK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAFK_ECOLI pepinfo swissprot:YAFK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAFK_ECOLI pepnet swissprot:YAFK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAFK_ECOLI pepstats swissprot:YAFK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAFK_ECOLI pepwheel swissprot:YAFK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAFK_ECOLI pepwindow swissprot:YAFK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAFK_ECOLI sigcleave swissprot:YAFK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAFK_ECOLI ## Database ID URL or Descriptions # AltName RIDA_ECOLI Enamine/imine deaminase # BioGrid 4262720 8 # CATALYTIC ACTIVITY RIDA_ECOLI 2-iminobutanoate + H(2)O = 2-oxobutanoate + NH(3). # CATALYTIC ACTIVITY RIDA_ECOLI 2-iminopropanoate + H(2)O = pyruvate + NH(3). # EcoGene EG12524 ridA # FUNCTION RIDA_ECOLI Accelerates the release of ammonia from reactive enamine/imine intermediates of the PLP-dependent threonine dehydratase (IlvA) in the low water environment of the cell. It catalyzes the deamination of enamine/imine intermediates to yield 2-ketobutyrate and ammonia. It is required for the detoxification of reactive intermediates of IlvA due to their highly nucleophilic abilities. Involved in the isoleucine biosynthesis (By similarity). {ECO 0000250}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0016787 hydrolase activity; IEA:UniProtKB-KW. # GO_function GO:0019239 deaminase activity; ISS:UniProtKB. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0051082 unfolded protein binding; IDA:EcoCyc. # GO_process GO:0008652 cellular amino acid biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0009097 isoleucine biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0009636 response to toxic substance; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0051082 unfolded protein binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.30.1330.40 -; 1. # InterPro IPR006056 RidA # InterPro IPR006175 YjgF/YER057c/UK114 # InterPro IPR013813 Endoribo_LPSP/chorism_mut-like # InterPro IPR019897 RidA_CS # Organism RIDA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11803 PTHR11803 # PATHWAY RIDA_ECOLI Amino-acid biosynthesis; L-isoleucine biosynthesis; 2- oxobutanoate from L-threonine. # PATRIC 32124063 VBIEscCol129921_4376 # PDB 1QU9 X-ray; 1.20 A; A/B/C=1-128 # PROSITE PS01094 UPF0076 # Pfam PF01042 Ribonuc_L-PSP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RIDA_ECOLI 2-iminobutanoate/2-iminopropanoate deaminase # RefSeq NP_418664 NC_000913.3 # RefSeq WP_000047539 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97140.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the RutC family. {ECO 0000305}. # SUBCELLULAR LOCATION RIDA_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Homotrimer. {ECO:0000269|PubMed 10595546}. # SUPFAM SSF55298 SSF55298 # TIGRFAMs TIGR00004 TIGR00004 # eggNOG COG0251 LUCA # eggNOG ENOG4105KME Bacteria BLAST swissprot:RIDA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RIDA_ECOLI BioCyc ECOL316407:JW5755-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5755-MONOMER BioCyc EcoCyc:G7877-MONOMER http://biocyc.org/getid?id=EcoCyc:G7877-MONOMER COG COG0251 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0251 DIP DIP-36232N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36232N DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1110/ps.8.11.2428 http://dx.doi.org/10.1110/ps.8.11.2428 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.5.99.10 http://www.genome.jp/dbget-bin/www_bget?EC:3.5.99.10 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 3.5.99.10 http://enzyme.expasy.org/EC/3.5.99.10 EchoBASE EB2415 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2415 EcoGene EG12524 http://www.ecogene.org/geneInfo.php?eg_id=EG12524 EnsemblBacteria AAC77200 http://www.ensemblgenomes.org/id/AAC77200 EnsemblBacteria AAC77200 http://www.ensemblgenomes.org/id/AAC77200 EnsemblBacteria BAE78242 http://www.ensemblgenomes.org/id/BAE78242 EnsemblBacteria BAE78242 http://www.ensemblgenomes.org/id/BAE78242 EnsemblBacteria BAE78242 http://www.ensemblgenomes.org/id/BAE78242 EnsemblBacteria b4243 http://www.ensemblgenomes.org/id/b4243 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0016787 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016787 GO_function GO:0019239 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019239 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0051082 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051082 GO_process GO:0008652 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008652 GO_process GO:0009097 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009097 GO_process GO:0009636 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009636 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0051082 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051082 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.30.1330.40 http://www.cathdb.info/version/latest/superfamily/3.30.1330.40 GeneID 948771 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948771 HOGENOM HOG000267215 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267215&db=HOGENOM6 InParanoid P0AF93 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AF93 IntEnz 3.5.99.10 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.99.10 InterPro IPR006056 http://www.ebi.ac.uk/interpro/entry/IPR006056 InterPro IPR006175 http://www.ebi.ac.uk/interpro/entry/IPR006175 InterPro IPR013813 http://www.ebi.ac.uk/interpro/entry/IPR013813 InterPro IPR019897 http://www.ebi.ac.uk/interpro/entry/IPR019897 KEGG_Gene ecj:JW5755 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5755 KEGG_Gene eco:b4243 http://www.genome.jp/dbget-bin/www_bget?eco:b4243 KEGG_Orthology KO:K09022 http://www.genome.jp/dbget-bin/www_bget?KO:K09022 OMA AGMDFNN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AGMDFNN PANTHER PTHR11803 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11803 PDB 1QU9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1QU9 PDBsum 1QU9 http://www.ebi.ac.uk/pdbsum/1QU9 PROSITE PS01094 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01094 PSORT swissprot:RIDA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RIDA_ECOLI PSORT-B swissprot:RIDA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RIDA_ECOLI PSORT2 swissprot:RIDA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RIDA_ECOLI Pfam PF01042 http://pfam.xfam.org/family/PF01042 Phobius swissprot:RIDA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RIDA_ECOLI PhylomeDB P0AF93 http://phylomedb.org/?seqid=P0AF93 ProteinModelPortal P0AF93 http://www.proteinmodelportal.org/query/uniprot/P0AF93 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 10595546 http://www.ncbi.nlm.nih.gov/pubmed/10595546 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_418664 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418664 RefSeq WP_000047539 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000047539 SMR P0AF93 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AF93 STRING 511145.b4243 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4243&targetmode=cogs STRING COG0251 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0251&targetmode=cogs SUPFAM SSF55298 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55298 SWISS-2DPAGE P0AF93 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AF93 TIGRFAMs TIGR00004 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00004 UniProtKB RIDA_ECOLI http://www.uniprot.org/uniprot/RIDA_ECOLI UniProtKB-AC P0AF93 http://www.uniprot.org/uniprot/P0AF93 charge swissprot:RIDA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RIDA_ECOLI eggNOG COG0251 http://eggnogapi.embl.de/nog_data/html/tree/COG0251 eggNOG ENOG4105KME http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KME epestfind swissprot:RIDA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RIDA_ECOLI garnier swissprot:RIDA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RIDA_ECOLI helixturnhelix swissprot:RIDA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RIDA_ECOLI hmoment swissprot:RIDA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RIDA_ECOLI iep swissprot:RIDA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RIDA_ECOLI inforesidue swissprot:RIDA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RIDA_ECOLI octanol swissprot:RIDA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RIDA_ECOLI pepcoil swissprot:RIDA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RIDA_ECOLI pepdigest swissprot:RIDA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RIDA_ECOLI pepinfo swissprot:RIDA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RIDA_ECOLI pepnet swissprot:RIDA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RIDA_ECOLI pepstats swissprot:RIDA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RIDA_ECOLI pepwheel swissprot:RIDA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RIDA_ECOLI pepwindow swissprot:RIDA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RIDA_ECOLI sigcleave swissprot:RIDA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RIDA_ECOLI ## Database ID URL or Descriptions # AltName CCDB_ECOLI Cytotoxic protein CcdB # AltName CCDB_ECOLI LynB # AltName CCDB_ECOLI Protein G # AltName CCDB_ECOLI Protein LetD # DISRUPTION PHENOTYPE CCDB_ECOLI Disruption of both ccdA and ccdB has no phenotype, except for increased plasmid loss. {ECO 0000269|PubMed 6227479, ECO 0000269|PubMed 6308648}. # FUNCTION CCDB_ECOLI Toxic component of a toxin-antitoxin (TA) module, functioning in plasmid maintainence. Responsible for the post- segregational killing (PSK) of plasmid-free cells, also referred to as a plasmid addiction system. Half-life of over 2 hours. Cell killing by CcdB is accompanied by filamentation, defects in chromosome and plasmid segregation, defects in cell division, formation of anucleate cells, decreased DNA synthesis and plasmid loss. Interferes with the activity of DNA gyrase, inducing it to form a covalent GyrA-DNA complex that cannot be resolved, thus promoting breakage of plasmid and chromosomal DNA. DNA breakage requires hydrolyzable ATP. Toxicity is inhibited by labile antitoxin CcdA, which blocks the activity of CcdB; CcdA also removes bound CcdB protein from the CcdB-GyrA complex by forming a CcdA-CcdB complex, a process termed rejuvenation. Also acts to inhibit partitioning of the chromosomal DNA. Functions as a transcriptional corepressor for the ccdAB operon, repression also requires CcdA. {ECO 0000269|PubMed 1324324, ECO 0000269|PubMed 2615761, ECO 0000269|PubMed 2651399, ECO 0000269|PubMed 6308648, ECO 0000269|PubMed 6327993, ECO 0000269|PubMed 8604132}. # GO_function GO:0008657 DNA topoisomerase (ATP-hydrolyzing) inhibitor activity; IEA:InterPro. # GO_process GO:0006276 plasmid maintenance; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_function GO:0030234 enzyme regulator activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 2.30.30.110 -; 1. # InterPro IPR002712 CcdB # InterPro IPR011067 Plasmid_toxin/cell-grow_inhib # Organism CCDB_ECOLI Escherichia coli (strain K12) # PDB 1VUB X-ray; 2.60 A; A/B/C/D=1-101 # PDB 1X75 X-ray; 2.80 A; C/D=1-101 # PDB 2VUB X-ray; 2.45 A; A/B/C/D/E/F/G/H=1-101 # PDB 3G7Z X-ray; 2.35 A; A/B=1-101 # PDB 3HPW X-ray; 1.45 A; A/B=1-101 # PDB 3VUB X-ray; 1.40 A; A=1-101 # PDB 4VUB X-ray; 1.45 A; A=1-101 # PIR T00238 T00238 # Pfam PF01845 CcdB # ProDom PD012578 PD012578 # RecName CCDB_ECOLI Toxin CcdB # RefSeq NP_061422 NC_002483.1 # RefSeq WP_001159868 NZ_CP014273.1 # RefSeq YP_003108267 NC_013122.1 # SIMILARITY Belongs to the CcdB toxin family. {ECO 0000305}. # SUBUNIT CCDB_ECOLI Homodimer. Forms a complex with GyrA, probably a tetramer GyrA(2)CcdB(2), in which GyrA is inactive. Forms a complex with antitoxin CcdA; there are both high- and low-affinity binding sites for CcdA such that both CcdA-CcdB(2) and CcdA(2)CcdB(2) complexes can form. The CcdA-CcdB(2) trimer is sufficient for rejuvenation, whereas maximal operon repression occurs with CcdA(2)CcdB(2). When the CcdA CcdB ratio is lower than 1, a CcdA(2)-CcdB(4) complex is formed which is devoid of repression activity. In this case repression is alleviated and both proteins are produced. {ECO 0000269|PubMed 15854646, ECO 0000269|PubMed 19647513, ECO 0000269|PubMed 2615761, ECO 0000269|PubMed 2651399, ECO 0000269|PubMed 8604132, ECO 0000269|PubMed 9917404}. # SUPFAM SSF50118 SSF50118 BLAST swissprot:CCDB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CCDB_ECOLI DOI 10.1006/jmbi.1993.1609 http://dx.doi.org/10.1006/jmbi.1993.1609 DOI 10.1006/jmbi.1996.0102 http://dx.doi.org/10.1006/jmbi.1996.0102 DOI 10.1006/jmbi.1998.2395 http://dx.doi.org/10.1006/jmbi.1998.2395 DOI 10.1007/BF00261153 http://dx.doi.org/10.1007/BF00261153 DOI 10.1016/0022-2836(84)90086-X http://dx.doi.org/10.1016/0022-2836(84)90086-X DOI 10.1016/0022-2836(92)90629-X http://dx.doi.org/10.1016/0022-2836(92)90629-X DOI 10.1016/j.jmb.2005.03.049 http://dx.doi.org/10.1016/j.jmb.2005.03.049 DOI 10.1016/j.molcel.2009.05.025 http://dx.doi.org/10.1016/j.molcel.2009.05.025 DOI 10.1046/j.1365-2958.2001.02492.x http://dx.doi.org/10.1046/j.1365-2958.2001.02492.x DOI 10.1073/pnas.80.15.4784 http://dx.doi.org/10.1073/pnas.80.15.4784 DOI 10.1111/j.1365-2958.1994.tb00391.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb00391.x DOI 10.1111/j.1365-2958.1995.tb02278.x http://dx.doi.org/10.1111/j.1365-2958.1995.tb02278.x EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL M12987 http://www.ebi.ac.uk/ena/data/view/M12987 EMBL X00594 http://www.ebi.ac.uk/ena/data/view/X00594 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008657 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008657 GO_process GO:0006276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006276 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 2.30.30.110 http://www.cathdb.info/version/latest/superfamily/2.30.30.110 GeneID 1263593 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263593 GeneID 8319210 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8319210 InterPro IPR002712 http://www.ebi.ac.uk/interpro/entry/IPR002712 InterPro IPR011067 http://www.ebi.ac.uk/interpro/entry/IPR011067 OMA RLMTTDM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RLMTTDM PDB 1VUB http://www.ebi.ac.uk/pdbe-srv/view/entry/1VUB PDB 1X75 http://www.ebi.ac.uk/pdbe-srv/view/entry/1X75 PDB 2VUB http://www.ebi.ac.uk/pdbe-srv/view/entry/2VUB PDB 3G7Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3G7Z PDB 3HPW http://www.ebi.ac.uk/pdbe-srv/view/entry/3HPW PDB 3VUB http://www.ebi.ac.uk/pdbe-srv/view/entry/3VUB PDB 4VUB http://www.ebi.ac.uk/pdbe-srv/view/entry/4VUB PDBsum 1VUB http://www.ebi.ac.uk/pdbsum/1VUB PDBsum 1X75 http://www.ebi.ac.uk/pdbsum/1X75 PDBsum 2VUB http://www.ebi.ac.uk/pdbsum/2VUB PDBsum 3G7Z http://www.ebi.ac.uk/pdbsum/3G7Z PDBsum 3HPW http://www.ebi.ac.uk/pdbsum/3HPW PDBsum 3VUB http://www.ebi.ac.uk/pdbsum/3VUB PDBsum 4VUB http://www.ebi.ac.uk/pdbsum/4VUB PSORT swissprot:CCDB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CCDB_ECOLI PSORT-B swissprot:CCDB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CCDB_ECOLI PSORT2 swissprot:CCDB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CCDB_ECOLI Pfam PF01845 http://pfam.xfam.org/family/PF01845 Phobius swissprot:CCDB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CCDB_ECOLI ProteinModelPortal P62554 http://www.proteinmodelportal.org/query/uniprot/P62554 PubMed 11454201 http://www.ncbi.nlm.nih.gov/pubmed/11454201 PubMed 1324324 http://www.ncbi.nlm.nih.gov/pubmed/1324324 PubMed 15854646 http://www.ncbi.nlm.nih.gov/pubmed/15854646 PubMed 19647513 http://www.ncbi.nlm.nih.gov/pubmed/19647513 PubMed 2615761 http://www.ncbi.nlm.nih.gov/pubmed/2615761 PubMed 2651399 http://www.ncbi.nlm.nih.gov/pubmed/2651399 PubMed 6227479 http://www.ncbi.nlm.nih.gov/pubmed/6227479 PubMed 6308648 http://www.ncbi.nlm.nih.gov/pubmed/6308648 PubMed 6327993 http://www.ncbi.nlm.nih.gov/pubmed/6327993 PubMed 7623659 http://www.ncbi.nlm.nih.gov/pubmed/7623659 PubMed 8022284 http://www.ncbi.nlm.nih.gov/pubmed/8022284 PubMed 8254658 http://www.ncbi.nlm.nih.gov/pubmed/8254658 PubMed 8604132 http://www.ncbi.nlm.nih.gov/pubmed/8604132 PubMed 9917404 http://www.ncbi.nlm.nih.gov/pubmed/9917404 RefSeq NP_061422 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061422 RefSeq WP_001159868 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001159868 RefSeq YP_003108267 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_003108267 SMR P62554 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P62554 SUPFAM SSF50118 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50118 UniProtKB CCDB_ECOLI http://www.uniprot.org/uniprot/CCDB_ECOLI UniProtKB-AC P62554 http://www.uniprot.org/uniprot/P62554 charge swissprot:CCDB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CCDB_ECOLI epestfind swissprot:CCDB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CCDB_ECOLI garnier swissprot:CCDB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CCDB_ECOLI helixturnhelix swissprot:CCDB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CCDB_ECOLI hmoment swissprot:CCDB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CCDB_ECOLI iep swissprot:CCDB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CCDB_ECOLI inforesidue swissprot:CCDB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CCDB_ECOLI octanol swissprot:CCDB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CCDB_ECOLI pepcoil swissprot:CCDB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CCDB_ECOLI pepdigest swissprot:CCDB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CCDB_ECOLI pepinfo swissprot:CCDB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CCDB_ECOLI pepnet swissprot:CCDB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CCDB_ECOLI pepstats swissprot:CCDB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CCDB_ECOLI pepwheel swissprot:CCDB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CCDB_ECOLI pepwindow swissprot:CCDB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CCDB_ECOLI sigcleave swissprot:CCDB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CCDB_ECOLI ## Database ID URL or Descriptions # AltName EIIB-Gat {ECO:0000303|PubMed 7772602} # AltName Galactitol-specific phosphotransferase enzyme IIB component {ECO:0000303|PubMed 7772602} # BIOPHYSICOCHEMICAL PROPERTIES PTKB_ECOLI Kinetic parameters KM=4.4 uM for D-galactitol {ECO 0000269|PubMed 1100608}; KM=800 uM for D-glucitol {ECO 0000269|PubMed 1100608}; Vmax=3.2 nmol/min/mg enzyme with D-galactitol as substrate {ECO 0000269|PubMed 1100608}; Vmax=3.2 nmol/min/mg enzyme with D-glucitol as substrate {ECO 0000269|PubMed 1100608}; # BioGrid 4263510 9 # CATALYTIC ACTIVITY [Protein]-N(pi)-phospho-L-histidine + galactitol(Side 1) = [protein]-L-histidine + galactitol 1- phosphate(Side 2). {ECO:0000269|PubMed 1100608}. # DOMAIN PTKB_ECOLI The EIIB domain is phosphorylated by phospho-EIIA on a cysteinyl or histidyl residue, depending on the transported sugar. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the EIIC domain. {ECO 0000255|PROSITE-ProRule PRU00422}. # EcoGene EG12415 gatB # FUNCTION PTKB_ECOLI The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. The enzyme II complex composed of GatA, GatB and GatC is involved in galactitol transport. It can also use D-glucitol. {ECO 0000269|PubMed 1100608, ECO 0000269|PubMed 8955298}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008982 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:InterPro. # GO_function GO:0090584 protein-phosphocysteine-galactitol-phosphotransferase system transporter activity; IDA:EcoCyc. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IDA:EcoCyc. # GO_process GO:0015796 galactitol transport; IDA:EcoCyc. # GO_process GO:0019402 galactitol metabolic process; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006810 transport # GOslim_process GO:0044281 small molecule metabolic process # INDUCTION Constitutively expressed. {ECO:0000269|PubMed 8955298}. # IntAct P37188 7 # InterPro IPR003501 PTS_EIIB_2/3 # InterPro IPR013011 PTS_EIIB_2 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00279 PTS system, galactitol-specific II component # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko00052 Galactose metabolism # KEGG_Pathway ko02060 Phosphotransferase system (PTS) # Organism PTKB_ECOLI Escherichia coli (strain K12) # PATRIC 32119519 VBIEscCol129921_2170 # PIR D64976 D64976 # PIR S55904 S55904 # PROSITE PS51099 PTS_EIIB_TYPE_2 # Pfam PF02302 PTS_IIB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PTS system galactitol-specific EIIB component {ECO:0000303|PubMed 7772602} # RefSeq NP_416596 NC_000913.3 # RefSeq WP_000823270 NZ_LN832404.1 # SIMILARITY Contains 1 PTS EIIB type-2 domain. {ECO:0000255|PROSITE-ProRule PRU00422}. # SUBCELLULAR LOCATION PTKB_ECOLI Cytoplasm {ECO 0000305|PubMed 8955298}. # SUBUNIT Forms a complex with one each of subunit of GatA, GatB and 2 subunits of GatC. {ECO:0000269|PubMed 16079137}. # SUPFAM SSF52794 SSF52794 # TCDB 4.A.5.1 the pts galactitol (gat) family # eggNOG COG3414 LUCA # eggNOG ENOG41090UW Bacteria BLAST swissprot:PTKB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTKB_ECOLI BioCyc ECOL316407:JW2077-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2077-MONOMER BioCyc EcoCyc:GATB-MONOMER http://biocyc.org/getid?id=EcoCyc:GATB-MONOMER BioCyc MetaCyc:GATB-MONOMER http://biocyc.org/getid?id=MetaCyc:GATB-MONOMER DIP DIP-9744N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9744N DOI 10.1016/0167-4781(95)00053-J http://dx.doi.org/10.1016/0167-4781(95)00053-J DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1111/j.1574-6968.1998.tb13343.x http://dx.doi.org/10.1111/j.1574-6968.1998.tb13343.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.200 {ECO:0000269|PubMed:1100608} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.200 {ECO:0000269|PubMed:1100608} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X79837 http://www.ebi.ac.uk/ena/data/view/X79837 ENZYME 2.7.1.200 {ECO:0000269|PubMed:1100608} http://enzyme.expasy.org/EC/2.7.1.200 {ECO:0000269|PubMed:1100608} EchoBASE EB2314 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2314 EcoGene EG12415 http://www.ecogene.org/geneInfo.php?eg_id=EG12415 EnsemblBacteria AAC75154 http://www.ensemblgenomes.org/id/AAC75154 EnsemblBacteria AAC75154 http://www.ensemblgenomes.org/id/AAC75154 EnsemblBacteria BAA15956 http://www.ensemblgenomes.org/id/BAA15956 EnsemblBacteria BAA15956 http://www.ensemblgenomes.org/id/BAA15956 EnsemblBacteria BAA15956 http://www.ensemblgenomes.org/id/BAA15956 EnsemblBacteria b2093 http://www.ensemblgenomes.org/id/b2093 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008982 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008982 GO_function GO:0090584 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090584 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GO_process GO:0015796 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015796 GO_process GO:0019402 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019402 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 946610 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946610 HOGENOM HOG000230475 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230475&db=HOGENOM6 IntAct P37188 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37188* IntEnz 2.7.1.200 {ECO:0000269|PubMed:1100608} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.200 {ECO:0000269|PubMed:1100608} InterPro IPR003501 http://www.ebi.ac.uk/interpro/entry/IPR003501 InterPro IPR013011 http://www.ebi.ac.uk/interpro/entry/IPR013011 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2077 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2077 KEGG_Gene eco:b2093 http://www.genome.jp/dbget-bin/www_bget?eco:b2093 KEGG_Orthology KO:K02774 http://www.genome.jp/dbget-bin/www_bget?KO:K02774 KEGG_Pathway ko00052 http://www.genome.jp/kegg-bin/show_pathway?ko00052 KEGG_Pathway ko02060 http://www.genome.jp/kegg-bin/show_pathway?ko02060 KEGG_Reaction rn:R05570 http://www.genome.jp/dbget-bin/www_bget?rn:R05570 MINT MINT-1222883 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1222883 OMA ICTTAKI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ICTTAKI PROSITE PS51099 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51099 PSORT swissprot:PTKB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTKB_ECOLI PSORT-B swissprot:PTKB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTKB_ECOLI PSORT2 swissprot:PTKB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTKB_ECOLI Pfam PF02302 http://pfam.xfam.org/family/PF02302 Phobius swissprot:PTKB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTKB_ECOLI PhylomeDB P37188 http://phylomedb.org/?seqid=P37188 ProteinModelPortal P37188 http://www.proteinmodelportal.org/query/uniprot/P37188 PubMed 1100608 http://www.ncbi.nlm.nih.gov/pubmed/1100608 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7772602 http://www.ncbi.nlm.nih.gov/pubmed/7772602 PubMed 8955298 http://www.ncbi.nlm.nih.gov/pubmed/8955298 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9868784 http://www.ncbi.nlm.nih.gov/pubmed/9868784 RefSeq NP_416596 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416596 RefSeq WP_000823270 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000823270 SMR P37188 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37188 STRING 511145.b2093 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2093&targetmode=cogs SUPFAM SSF52794 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52794 TCDB 4.A.5.1 http://www.tcdb.org/search/result.php?tc=4.A.5.1 UniProtKB PTKB_ECOLI http://www.uniprot.org/uniprot/PTKB_ECOLI UniProtKB-AC P37188 http://www.uniprot.org/uniprot/P37188 charge swissprot:PTKB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTKB_ECOLI eggNOG COG3414 http://eggnogapi.embl.de/nog_data/html/tree/COG3414 eggNOG ENOG41090UW http://eggnogapi.embl.de/nog_data/html/tree/ENOG41090UW epestfind swissprot:PTKB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTKB_ECOLI garnier swissprot:PTKB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTKB_ECOLI helixturnhelix swissprot:PTKB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTKB_ECOLI hmoment swissprot:PTKB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTKB_ECOLI iep swissprot:PTKB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTKB_ECOLI inforesidue swissprot:PTKB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTKB_ECOLI octanol swissprot:PTKB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTKB_ECOLI pepcoil swissprot:PTKB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTKB_ECOLI pepdigest swissprot:PTKB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTKB_ECOLI pepinfo swissprot:PTKB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTKB_ECOLI pepnet swissprot:PTKB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTKB_ECOLI pepstats swissprot:PTKB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTKB_ECOLI pepwheel swissprot:PTKB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTKB_ECOLI pepwindow swissprot:PTKB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTKB_ECOLI sigcleave swissprot:PTKB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTKB_ECOLI ## Database ID URL or Descriptions # AltName CH10_ECOLI GroES protein # AltName CH10_ECOLI Protein Cpn10 # BioGrid 4262198 133 # CDD cd00320 cpn10 # EcoGene EG10600 groS # FUNCTION CH10_ECOLI Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:1990220 GroEL-GroES complex; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:InterPro. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IBA:GO_Central. # GO_function GO:0051082 unfolded protein binding; IBA:GO_Central. # GO_function GO:0051087 chaperone binding; IBA:GO_Central. # GO_process GO:0006457 protein folding; IDA:CACAO. # GO_process GO:0006986 response to unfolded protein; IBA:GO_Central. # GO_process GO:0007049 cell cycle; IEA:UniProtKB-KW. # GO_process GO:0009408 response to heat; IEP:EcoliWiki. # GO_process GO:0019068 virion assembly; IMP:EcoliWiki. # GO_process GO:0051085 chaperone mediated protein folding requiring cofactor; IDA:EcoCyc. # GO_process GO:0051301 cell division; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_function GO:0051082 unfolded protein binding # GOslim_process GO:0006457 protein folding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0007049 cell cycle # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0044403 symbiosis, encompassing mutualism through parasitism # GOslim_process GO:0051301 cell division # Gene3D 2.30.33.40 -; 1. # HAMAP MF_00580 CH10 # INTERACTION CH10_ECOLI Self; NbExp=2; IntAct=EBI-369169, EBI-369169; P0A6F5 groL; NbExp=25; IntAct=EBI-369169, EBI-543750; # IntAct P0A6F9 28 # InterPro IPR011032 GroES-like # InterPro IPR018369 Chaprnonin_Cpn10_CS # InterPro IPR020818 Chaperonin_GroES # KEGG_Brite ko03110 Chaperones and folding catalysts # Organism CH10_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10772 PTHR10772 # PATRIC 32123853 VBIEscCol129921_4274 # PDB 1AON X-ray; 3.00 A; O/P/Q/R/S/T/U=1-97 # PDB 1EGS NMR; -; A=19-27 # PDB 1GRU EM; 12.50 A; O/P/Q/R/S/T/U=1-97 # PDB 1PCQ X-ray; 2.81 A; O/P/Q/R/S/T/U=1-97 # PDB 1PF9 X-ray; 2.99 A; O/P/Q/R/S/T/U=1-97 # PDB 1SVT X-ray; 2.81 A; O/P/Q/R/S/T/U=1-97 # PDB 1SX4 X-ray; 3.00 A; O/P/Q/R/S/T/U=1-97 # PDB 2C7C EM; 7.70 A; O/P/Q/R/S/T/U=1-97 # PDB 2C7D EM; 8.70 A; O/P/Q/R/S/T/U=1-97 # PDB 3WVL X-ray; 3.79 A; O/P/Q/R/S/T/U/V/W/X/Y/Z/a/b=1-97 # PDB 3ZPZ EM; 8.90 A; O/P/Q/R/S/T/U=1-97 # PDB 3ZQ0 EM; 9.20 A; O/P/Q/R/S/T/U=1-97 # PDB 3ZQ1 EM; 15.90 A; O/P/Q/R/S/T/U=1-97 # PIR S03931 BVECGS # PRINTS PR00297 CHAPERONIN10 # PROSITE PS00681 CHAPERONINS_CPN10 # Pfam PF00166 Cpn10 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CH10_ECOLI 10 kDa chaperonin # RefSeq NP_418566 NC_000913.3 # RefSeq WP_001026276 NZ_LN832404.1 # SIMILARITY Belongs to the GroES chaperonin family. {ECO 0000305}. # SMART SM00883 Cpn10 # SUBCELLULAR LOCATION CH10_ECOLI Cytoplasm {ECO 0000269|PubMed 22380631}. Note=Exclusively localized in foci, usually near 1 cell pole in mid-to-late exponential phase; polar localization depends on the minCDE operon. Foci form near midcell. # SUBUNIT CH10_ECOLI Heptamer of 7 subunits arranged in a ring. # SUPFAM SSF50129 SSF50129 # eggNOG COG0234 LUCA # eggNOG ENOG4105K5Y Bacteria BLAST swissprot:CH10_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CH10_ECOLI BioCyc ECOL316407:JW4102-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4102-MONOMER BioCyc EcoCyc:EG10600-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10600-MONOMER BioCyc MetaCyc:EG10600-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10600-MONOMER COG COG0234 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0234 DIP DIP-9835N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9835N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1998.1726 http://dx.doi.org/10.1006/jmbi.1998.1726 DOI 10.1016/0022-2836(88)90141-6 http://dx.doi.org/10.1016/0022-2836(88)90141-6 DOI 10.1038/333330a0 http://dx.doi.org/10.1038/333330a0 DOI 10.1038/366279a0 http://dx.doi.org/10.1038/366279a0 DOI 10.1038/379037a0 http://dx.doi.org/10.1038/379037a0 DOI 10.1038/41944 http://dx.doi.org/10.1038/41944 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nchembio.495 http://dx.doi.org/10.1038/nchembio.495 DOI 10.1073/pnas.90.11.5011 http://dx.doi.org/10.1073/pnas.90.11.5011 DOI 10.1073/pnas.93.21.11622 http://dx.doi.org/10.1073/pnas.93.21.11622 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1111/j.1365-2958.2012.08021.x http://dx.doi.org/10.1111/j.1365-2958.2012.08021.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X07850 http://www.ebi.ac.uk/ena/data/view/X07850 EMBL X07899 http://www.ebi.ac.uk/ena/data/view/X07899 EchoBASE EB0595 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0595 EcoGene EG10600 http://www.ecogene.org/geneInfo.php?eg_id=EG10600 EnsemblBacteria AAC77102 http://www.ensemblgenomes.org/id/AAC77102 EnsemblBacteria AAC77102 http://www.ensemblgenomes.org/id/AAC77102 EnsemblBacteria BAE78144 http://www.ensemblgenomes.org/id/BAE78144 EnsemblBacteria BAE78144 http://www.ensemblgenomes.org/id/BAE78144 EnsemblBacteria BAE78144 http://www.ensemblgenomes.org/id/BAE78144 EnsemblBacteria b4142 http://www.ensemblgenomes.org/id/b4142 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:1990220 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990220 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051082 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051082 GO_function GO:0051087 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051087 GO_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GO_process GO:0006986 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006986 GO_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GO_process GO:0019068 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019068 GO_process GO:0051085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051085 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_function GO:0051082 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051082 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0044403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 Gene3D 2.30.33.40 http://www.cathdb.info/version/latest/superfamily/2.30.33.40 GeneID 948655 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948655 HAMAP MF_00580 http://hamap.expasy.org/unirule/MF_00580 HOGENOM HOG000133897 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000133897&db=HOGENOM6 InParanoid P0A6F9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6F9 IntAct P0A6F9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6F9* InterPro IPR011032 http://www.ebi.ac.uk/interpro/entry/IPR011032 InterPro IPR018369 http://www.ebi.ac.uk/interpro/entry/IPR018369 InterPro IPR020818 http://www.ebi.ac.uk/interpro/entry/IPR020818 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW4102 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4102 KEGG_Gene eco:b4142 http://www.genome.jp/dbget-bin/www_bget?eco:b4142 KEGG_Orthology KO:K04078 http://www.genome.jp/dbget-bin/www_bget?KO:K04078 MINT MINT-5232475 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-5232475 OMA VMGENEI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VMGENEI PANTHER PTHR10772 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10772 PDB 1AON http://www.ebi.ac.uk/pdbe-srv/view/entry/1AON PDB 1EGS http://www.ebi.ac.uk/pdbe-srv/view/entry/1EGS PDB 1GRU http://www.ebi.ac.uk/pdbe-srv/view/entry/1GRU PDB 1PCQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1PCQ PDB 1PF9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1PF9 PDB 1SVT http://www.ebi.ac.uk/pdbe-srv/view/entry/1SVT PDB 1SX4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1SX4 PDB 2C7C http://www.ebi.ac.uk/pdbe-srv/view/entry/2C7C PDB 2C7D http://www.ebi.ac.uk/pdbe-srv/view/entry/2C7D PDB 3WVL http://www.ebi.ac.uk/pdbe-srv/view/entry/3WVL PDB 3ZPZ http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZPZ PDB 3ZQ0 http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZQ0 PDB 3ZQ1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZQ1 PDBsum 1AON http://www.ebi.ac.uk/pdbsum/1AON PDBsum 1EGS http://www.ebi.ac.uk/pdbsum/1EGS PDBsum 1GRU http://www.ebi.ac.uk/pdbsum/1GRU PDBsum 1PCQ http://www.ebi.ac.uk/pdbsum/1PCQ PDBsum 1PF9 http://www.ebi.ac.uk/pdbsum/1PF9 PDBsum 1SVT http://www.ebi.ac.uk/pdbsum/1SVT PDBsum 1SX4 http://www.ebi.ac.uk/pdbsum/1SX4 PDBsum 2C7C http://www.ebi.ac.uk/pdbsum/2C7C PDBsum 2C7D http://www.ebi.ac.uk/pdbsum/2C7D PDBsum 3WVL http://www.ebi.ac.uk/pdbsum/3WVL PDBsum 3ZPZ http://www.ebi.ac.uk/pdbsum/3ZPZ PDBsum 3ZQ0 http://www.ebi.ac.uk/pdbsum/3ZQ0 PDBsum 3ZQ1 http://www.ebi.ac.uk/pdbsum/3ZQ1 PRINTS PR00297 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00297 PROSITE PS00681 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00681 PSORT swissprot:CH10_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CH10_ECOLI PSORT-B swissprot:CH10_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CH10_ECOLI PSORT2 swissprot:CH10_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CH10_ECOLI Pfam PF00166 http://pfam.xfam.org/family/PF00166 Phobius swissprot:CH10_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CH10_ECOLI PhylomeDB P0A6F9 http://phylomedb.org/?seqid=P0A6F9 ProteinModelPortal P0A6F9 http://www.proteinmodelportal.org/query/uniprot/P0A6F9 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21151122 http://www.ncbi.nlm.nih.gov/pubmed/21151122 PubMed 22380631 http://www.ncbi.nlm.nih.gov/pubmed/22380631 PubMed 2897629 http://www.ncbi.nlm.nih.gov/pubmed/2897629 PubMed 2901493 http://www.ncbi.nlm.nih.gov/pubmed/2901493 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 7901771 http://www.ncbi.nlm.nih.gov/pubmed/7901771 PubMed 8506346 http://www.ncbi.nlm.nih.gov/pubmed/8506346 PubMed 8538739 http://www.ncbi.nlm.nih.gov/pubmed/8538739 PubMed 8876186 http://www.ncbi.nlm.nih.gov/pubmed/8876186 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9285585 http://www.ncbi.nlm.nih.gov/pubmed/9285585 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 RefSeq NP_418566 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418566 RefSeq WP_001026276 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001026276 SMART SM00883 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00883 SMR P0A6F9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6F9 STRING 511145.b4142 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4142&targetmode=cogs STRING COG0234 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0234&targetmode=cogs SUPFAM SSF50129 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50129 SWISS-2DPAGE P0A6F9 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A6F9 UniProtKB CH10_ECOLI http://www.uniprot.org/uniprot/CH10_ECOLI UniProtKB-AC P0A6F9 http://www.uniprot.org/uniprot/P0A6F9 charge swissprot:CH10_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CH10_ECOLI eggNOG COG0234 http://eggnogapi.embl.de/nog_data/html/tree/COG0234 eggNOG ENOG4105K5Y http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K5Y epestfind swissprot:CH10_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CH10_ECOLI garnier swissprot:CH10_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CH10_ECOLI helixturnhelix swissprot:CH10_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CH10_ECOLI hmoment swissprot:CH10_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CH10_ECOLI iep swissprot:CH10_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CH10_ECOLI inforesidue swissprot:CH10_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CH10_ECOLI octanol swissprot:CH10_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CH10_ECOLI pepcoil swissprot:CH10_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CH10_ECOLI pepdigest swissprot:CH10_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CH10_ECOLI pepinfo swissprot:CH10_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CH10_ECOLI pepnet swissprot:CH10_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CH10_ECOLI pepstats swissprot:CH10_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CH10_ECOLI pepwheel swissprot:CH10_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CH10_ECOLI pepwindow swissprot:CH10_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CH10_ECOLI sigcleave swissprot:CH10_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CH10_ECOLI ## Database ID URL or Descriptions # AltName PAAZ_ECOLI Oxepin-CoA hydrolase # AltName PAAZ_ECOLI Oxepin-CoA hydrolase # BIOPHYSICOCHEMICAL PROPERTIES PAAZ_ECOLI Kinetic parameters KM=11 uM for oxepin-CoA (at 22 degrees Celsius and pH 8) {ECO 0000269|PubMed 21296885}; KM=56 uM for NADP (at 22 degrees Celsius and pH 8) {ECO 0000269|PubMed 21296885}; pH dependence Optimum pH is 8. {ECO 0000269|PubMed 21296885}; # BRENDA 3.3.2.12 2026 # BioGrid 4260176 262 # CATALYTIC ACTIVITY 2-oxepin-2(3H)-ylideneacetyl-CoA + H(2)O = 3- oxo-5,6-dehydrosuberyl-CoA semialdehyde. {ECO:0000269|PubMed 21296885}. # CATALYTIC ACTIVITY 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde + NADP(+) + H(2)O = 3-oxo-5,6-dehydrosuberyl-CoA + NADPH. {ECO:0000269|PubMed 21296885}. # DISRUPTION PHENOTYPE Disruption causes the conversion of phenylacetate (PA) into 2-hydroxyphenylacetate (2-HPA). {ECO:0000269|PubMed 9748275}. # EcoGene EG13735 paaZ # FUNCTION PAAZ_ECOLI Catalyzes the hydrolytic ring cleavage of 2-oxepin- 2(3H)-ylideneacetyl-CoA (oxepin-CoA) via the open-chain aldehyde intermediate to yield 3-oxo-5,6-dehydrosuberyl-CoA. The enzyme consists of a C-terminal (R)-specific enoyl-CoA hydratase domain (formerly MaoC) that cleaves the ring and produces the highly reactive 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde and an N- terminal NADP-dependent aldehyde dehydrogenase domain that oxidizes the aldehyde to 3-oxo-5,6-dehydrosuberyl-CoA. Can also use crotonyl-CoA as substrate. {ECO 0000269|PubMed 20660314, ECO 0000269|PubMed 21296885, ECO 0000269|PubMed 9748275}. # GO_function GO:0004029 aldehyde dehydrogenase (NAD) activity; IBA:GO_Central. # GO_function GO:0004300 enoyl-CoA hydratase activity; IDA:EcoCyc. # GO_function GO:0016726 oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor; IDA:UniProtKB. # GO_function GO:0016803 ether hydrolase activity; IDA:EcoCyc. # GO_function GO:0016823 hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances; IDA:UniProtKB. # GO_process GO:0010124 phenylacetate catabolic process; IMP:UniProtKB. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.10.129.10 -; 1. # Gene3D 3.40.309.10 -; 1. # Gene3D 3.40.605.10 -; 1. # INDUCTION Activated by cAMP receptor protein (CRP) and integration host factor (IHF). Inhibited by PaaX. {ECO:0000269|PubMed 10766858}. # IntAct P77455 3 # InterPro IPR002539 MaoC_dom # InterPro IPR011966 PaaN-DH # InterPro IPR015590 Aldehyde_DH_dom # InterPro IPR016161 Ald_DH/histidinol_DH # InterPro IPR016162 Ald_DH_N # InterPro IPR016163 Ald_DH_C # InterPro IPR029069 HotDog_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00360 Phenylalanine metabolism # Organism PAAZ_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11699:SF12 PTHR11699:SF12 # PATHWAY PAAZ_ECOLI Aromatic compound metabolism; phenylacetate degradation. # PATRIC 32118060 VBIEscCol129921_1450 # PIR F64889 F64889 # Pfam PF00171 Aldedh # Pfam PF01575 MaoC_dehydratas # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PAAZ_ECOLI 2-oxepin-2(3H)-ylideneacetyl-CoA hydrolase # RecName PAAZ_ECOLI 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase # RecName PAAZ_ECOLI Bifunctional protein PaaZ # RecName PAAZ_ECOLI Bifunctional protein PaaZ # RefSeq NP_415905 NC_000913.3 # RefSeq WP_001186469 NZ_LN832404.1 # SIMILARITY Contains 1 MaoC-like domain. {ECO 0000305}. # SIMILARITY In the N-terminal section; belongs to the aldehyde dehydrogenase family. {ECO 0000305}. # SUPFAM SSF53720 SSF53720 # SUPFAM SSF54637 SSF54637 # TIGRFAMs TIGR02278 PaaN-DH # eggNOG COG2030 LUCA # eggNOG ENOG4105DXM Bacteria BLAST swissprot:PAAZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PAAZ_ECOLI BioCyc ECOL316407:JW1382-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1382-MONOMER BioCyc EcoCyc:G6708-MONOMER http://biocyc.org/getid?id=EcoCyc:G6708-MONOMER BioCyc MetaCyc:G6708-MONOMER http://biocyc.org/getid?id=MetaCyc:G6708-MONOMER COG COG1012 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1012 COG COG2030 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2030 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.1005399107 http://dx.doi.org/10.1073/pnas.1005399107 DOI 10.1074/jbc.273.40.25974 http://dx.doi.org/10.1074/jbc.273.40.25974 DOI 10.1074/jbc.275.16.12214 http://dx.doi.org/10.1074/jbc.275.16.12214 DOI 10.1074/jbc.M110.196667 http://dx.doi.org/10.1074/jbc.M110.196667 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.2.1.91 {ECO:0000269|PubMed:21296885} http://www.genome.jp/dbget-bin/www_bget?EC:1.2.1.91 {ECO:0000269|PubMed:21296885} EC_number EC:3.3.2.12 http://www.genome.jp/dbget-bin/www_bget?EC:3.3.2.12 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X97452 http://www.ebi.ac.uk/ena/data/view/X97452 ENZYME 1.2.1.91 {ECO:0000269|PubMed:21296885} http://enzyme.expasy.org/EC/1.2.1.91 {ECO:0000269|PubMed:21296885} ENZYME 3.3.2.12 http://enzyme.expasy.org/EC/3.3.2.12 EchoBASE EB3498 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3498 EcoGene EG13735 http://www.ecogene.org/geneInfo.php?eg_id=EG13735 EnsemblBacteria AAC74469 http://www.ensemblgenomes.org/id/AAC74469 EnsemblBacteria AAC74469 http://www.ensemblgenomes.org/id/AAC74469 EnsemblBacteria BAA14997 http://www.ensemblgenomes.org/id/BAA14997 EnsemblBacteria BAA14997 http://www.ensemblgenomes.org/id/BAA14997 EnsemblBacteria BAA14997 http://www.ensemblgenomes.org/id/BAA14997 EnsemblBacteria b1387 http://www.ensemblgenomes.org/id/b1387 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004029 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004029 GO_function GO:0004300 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004300 GO_function GO:0016726 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016726 GO_function GO:0016803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016803 GO_function GO:0016823 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016823 GO_process GO:0010124 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010124 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.10.129.10 http://www.cathdb.info/version/latest/superfamily/3.10.129.10 Gene3D 3.40.309.10 http://www.cathdb.info/version/latest/superfamily/3.40.309.10 Gene3D 3.40.605.10 http://www.cathdb.info/version/latest/superfamily/3.40.605.10 GeneID 945954 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945954 HOGENOM HOG000249929 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000249929&db=HOGENOM6 InParanoid P77455 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77455 IntAct P77455 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77455* IntEnz 1.2.1.91 {ECO:0000269|PubMed:21296885} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.2.1.91 {ECO:0000269|PubMed:21296885} IntEnz 3.3.2.12 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.3.2.12 InterPro IPR002539 http://www.ebi.ac.uk/interpro/entry/IPR002539 InterPro IPR011966 http://www.ebi.ac.uk/interpro/entry/IPR011966 InterPro IPR015590 http://www.ebi.ac.uk/interpro/entry/IPR015590 InterPro IPR016161 http://www.ebi.ac.uk/interpro/entry/IPR016161 InterPro IPR016162 http://www.ebi.ac.uk/interpro/entry/IPR016162 InterPro IPR016163 http://www.ebi.ac.uk/interpro/entry/IPR016163 InterPro IPR029069 http://www.ebi.ac.uk/interpro/entry/IPR029069 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1382 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1382 KEGG_Gene eco:b1387 http://www.genome.jp/dbget-bin/www_bget?eco:b1387 KEGG_Orthology KO:K02618 http://www.genome.jp/dbget-bin/www_bget?KO:K02618 KEGG_Pathway ko00360 http://www.genome.jp/kegg-bin/show_pathway?ko00360 KEGG_Reaction rn:R09820 http://www.genome.jp/dbget-bin/www_bget?rn:R09820 KEGG_Reaction rn:R09836 http://www.genome.jp/dbget-bin/www_bget?rn:R09836 OMA DTFYAHM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DTFYAHM PANTHER PTHR11699:SF12 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11699:SF12 PSORT swissprot:PAAZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PAAZ_ECOLI PSORT-B swissprot:PAAZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PAAZ_ECOLI PSORT2 swissprot:PAAZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PAAZ_ECOLI Pfam PF00171 http://pfam.xfam.org/family/PF00171 Pfam PF01575 http://pfam.xfam.org/family/PF01575 Phobius swissprot:PAAZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PAAZ_ECOLI PhylomeDB P77455 http://phylomedb.org/?seqid=P77455 ProteinModelPortal P77455 http://www.proteinmodelportal.org/query/uniprot/P77455 PubMed 10766858 http://www.ncbi.nlm.nih.gov/pubmed/10766858 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20660314 http://www.ncbi.nlm.nih.gov/pubmed/20660314 PubMed 21296885 http://www.ncbi.nlm.nih.gov/pubmed/21296885 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9748275 http://www.ncbi.nlm.nih.gov/pubmed/9748275 RefSeq NP_415905 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415905 RefSeq WP_001186469 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001186469 SMR P77455 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77455 STRING 511145.b1387 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1387&targetmode=cogs STRING COG1012 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1012&targetmode=cogs STRING COG2030 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2030&targetmode=cogs SUPFAM SSF53720 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53720 SUPFAM SSF54637 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54637 TIGRFAMs TIGR02278 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02278 UniProtKB PAAZ_ECOLI http://www.uniprot.org/uniprot/PAAZ_ECOLI UniProtKB-AC P77455 http://www.uniprot.org/uniprot/P77455 charge swissprot:PAAZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PAAZ_ECOLI eggNOG COG2030 http://eggnogapi.embl.de/nog_data/html/tree/COG2030 eggNOG ENOG4105DXM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DXM epestfind swissprot:PAAZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PAAZ_ECOLI garnier swissprot:PAAZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PAAZ_ECOLI helixturnhelix swissprot:PAAZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PAAZ_ECOLI hmoment swissprot:PAAZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PAAZ_ECOLI iep swissprot:PAAZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PAAZ_ECOLI inforesidue swissprot:PAAZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PAAZ_ECOLI octanol swissprot:PAAZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PAAZ_ECOLI pepcoil swissprot:PAAZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PAAZ_ECOLI pepdigest swissprot:PAAZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PAAZ_ECOLI pepinfo swissprot:PAAZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PAAZ_ECOLI pepnet swissprot:PAAZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PAAZ_ECOLI pepstats swissprot:PAAZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PAAZ_ECOLI pepwheel swissprot:PAAZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PAAZ_ECOLI pepwindow swissprot:PAAZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PAAZ_ECOLI sigcleave swissprot:PAAZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PAAZ_ECOLI ## Database ID URL or Descriptions # BioGrid 4263101 280 # DISRUPTION PHENOTYPE Disruption of both secD and SecF confers cold-sensitive growth (strain secD1(Cs)). {ECO:0000269|PubMed 2170107}. # EcoGene EG10940 secF # FUNCTION SECF_ECOLI Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. The large periplasmic domain is thought to have a base and head domain joined by a hinge; movement of the hinge may be coupled to both proton transport and protein export, with the head domain capturing substrate, and a conformational change preventing backward movement and driving forward movement. Expression of V.alginolyticus SecD and SecF in E.coli confers Na(+)-dependent protein export, strongly suggesting SecDF functions via cation-coupled protein translocation. {ECO 0000269|PubMed 21562494}. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity; IEA:InterPro. # GO_process GO:0006605 protein targeting; IEA:UniProtKB-HAMAP. # GO_process GO:0015031 protein transport; IBA:GO_Central. # GO_process GO:0043952 protein transport by the Sec complex; IEA:UniProtKB-HAMAP. # GO_process GO:0065002 intracellular protein transmembrane transport; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005622 intracellular # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0008565 protein transporter activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006605 protein targeting # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # HAMAP MF_01464_B SecF_B # InterPro IPR005665 SecF_bac # InterPro IPR022645 SecD/SecF_bac # InterPro IPR022646 SecD/SecF_CS # InterPro IPR022813 SecD/SecF_arch_bac # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02044 M00335 Sec (secretion) system # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko03060 Protein export # KEGG_Pathway ko03070 Bacterial secretion system # Organism SECF_ECOLI Escherichia coli (strain K12) # PATRIC 32115967 VBIEscCol129921_0425 # PIR JQ0697 JQ0697 # PRINTS PR01755 SECFTRNLCASE # Pfam PF02355 SecD_SecF # Pfam PF07549 Sec_GG # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SECF_ECOLI Protein translocase subunit SecF # RefSeq NP_414943 NC_000913.3 # RefSeq WP_000046637 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40165.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the SecD/SecF family. SecF subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION SECF_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT SECF_ECOLI Part of the prokaryotic protein translocation apparatus which is comprised of SecA, SecB, SecD, SecE, SecF, SecG and SecY. # TCDB 2.A.6.4 the resistance-nodulation-cell division (rnd) superfamily # TIGRFAMs TIGR00916 2A0604s01 # TIGRFAMs TIGR00966 3a0501s07 # eggNOG COG0341 LUCA # eggNOG ENOG4107RAB Bacteria BLAST swissprot:SECF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SECF_ECOLI BioCyc ECOL316407:JW0399-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0399-MONOMER BioCyc EcoCyc:SECF http://biocyc.org/getid?id=EcoCyc:SECF COG COG0341 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0341 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature09980 http://dx.doi.org/10.1038/nature09980 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL X56175 http://www.ebi.ac.uk/ena/data/view/X56175 EchoBASE EB0933 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0933 EcoGene EG10940 http://www.ecogene.org/geneInfo.php?eg_id=EG10940 EnsemblBacteria AAC73512 http://www.ensemblgenomes.org/id/AAC73512 EnsemblBacteria AAC73512 http://www.ensemblgenomes.org/id/AAC73512 EnsemblBacteria BAE76189 http://www.ensemblgenomes.org/id/BAE76189 EnsemblBacteria BAE76189 http://www.ensemblgenomes.org/id/BAE76189 EnsemblBacteria BAE76189 http://www.ensemblgenomes.org/id/BAE76189 EnsemblBacteria b0409 http://www.ensemblgenomes.org/id/b0409 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015450 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015450 GO_process GO:0006605 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006605 GO_process GO:0015031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031 GO_process GO:0043952 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043952 GO_process GO:0065002 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0065002 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006605 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006605 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 949120 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949120 HAMAP MF_01464_B http://hamap.expasy.org/unirule/MF_01464_B HOGENOM HOG000245914 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000245914&db=HOGENOM6 InParanoid P0AG93 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AG93 InterPro IPR005665 http://www.ebi.ac.uk/interpro/entry/IPR005665 InterPro IPR022645 http://www.ebi.ac.uk/interpro/entry/IPR022645 InterPro IPR022646 http://www.ebi.ac.uk/interpro/entry/IPR022646 InterPro IPR022813 http://www.ebi.ac.uk/interpro/entry/IPR022813 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW0399 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0399 KEGG_Gene eco:b0409 http://www.genome.jp/dbget-bin/www_bget?eco:b0409 KEGG_Orthology KO:K03074 http://www.genome.jp/dbget-bin/www_bget?KO:K03074 KEGG_Pathway ko03060 http://www.genome.jp/kegg-bin/show_pathway?ko03060 KEGG_Pathway ko03070 http://www.genome.jp/kegg-bin/show_pathway?ko03070 OMA MRWDNVA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MRWDNVA PRINTS PR01755 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01755 PSORT swissprot:SECF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SECF_ECOLI PSORT-B swissprot:SECF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SECF_ECOLI PSORT2 swissprot:SECF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SECF_ECOLI Pfam PF02355 http://pfam.xfam.org/family/PF02355 Pfam PF07549 http://pfam.xfam.org/family/PF07549 Phobius swissprot:SECF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SECF_ECOLI PhylomeDB P0AG93 http://phylomedb.org/?seqid=P0AG93 ProteinModelPortal P0AG93 http://www.proteinmodelportal.org/query/uniprot/P0AG93 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21562494 http://www.ncbi.nlm.nih.gov/pubmed/21562494 PubMed 2170107 http://www.ncbi.nlm.nih.gov/pubmed/2170107 PubMed 2249673 http://www.ncbi.nlm.nih.gov/pubmed/2249673 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414943 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414943 RefSeq WP_000046637 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000046637 SMR P0AG93 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AG93 STRING 511145.b0409 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0409&targetmode=cogs STRING COG0341 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0341&targetmode=cogs TCDB 2.A.6.4 http://www.tcdb.org/search/result.php?tc=2.A.6.4 TIGRFAMs TIGR00916 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00916 TIGRFAMs TIGR00966 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00966 UniProtKB SECF_ECOLI http://www.uniprot.org/uniprot/SECF_ECOLI UniProtKB-AC P0AG93 http://www.uniprot.org/uniprot/P0AG93 charge swissprot:SECF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SECF_ECOLI eggNOG COG0341 http://eggnogapi.embl.de/nog_data/html/tree/COG0341 eggNOG ENOG4107RAB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107RAB epestfind swissprot:SECF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SECF_ECOLI garnier swissprot:SECF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SECF_ECOLI helixturnhelix swissprot:SECF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SECF_ECOLI hmoment swissprot:SECF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SECF_ECOLI iep swissprot:SECF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SECF_ECOLI inforesidue swissprot:SECF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SECF_ECOLI octanol swissprot:SECF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SECF_ECOLI pepcoil swissprot:SECF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SECF_ECOLI pepdigest swissprot:SECF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SECF_ECOLI pepinfo swissprot:SECF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SECF_ECOLI pepnet swissprot:SECF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SECF_ECOLI pepstats swissprot:SECF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SECF_ECOLI pepwheel swissprot:SECF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SECF_ECOLI pepwindow swissprot:SECF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SECF_ECOLI sigcleave swissprot:SECF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SECF_ECOLI ## Database ID URL or Descriptions # BioGrid 4259344 8 # DISRUPTION PHENOTYPE Cells lacking this gene are viable, but those lacking both arfA and ssrA are non-viable. {ECO:0000269|PubMed 21062370}. # EcoGene EG11968 arfA # FUNCTION ARFA_ECOLI Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome cannot be rescued by the SsrA(tmRNA)-SmpB quality control system. {ECO 0000269|PubMed 21062370, ECO 0000269|PubMed 21435036}. # GO_function GO:0000049 tRNA binding; IDA:EcoCyc. # GO_function GO:0043023 ribosomal large subunit binding; IDA:EcoCyc. # GO_process GO:0072344 rescue of stalled ribosome; IDA:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003723 RNA binding # GOslim_process GO:0009058 biosynthetic process # InterPro IPR005589 DUF331 # KEGG_Brite ko03012 Translation factors # MISCELLANEOUS ArfA can be synthesized from truncated mRNA, via regulation by ribonuclease 3 and the SsrA tagging system. The arfA mRNA is cleaved by ribonuclease 3 within a hairpin structure, probably immediately after the Gly-55 codon, which produces a truncated non-stop transcript and leads to ribosome arrest. In the presence of SsrA, the stalled ribosome is rescued and the incomplete nascent ArfA is tagged for degradation. In the absence of SsrA, truncated ArfA chains are released from the ribosome and are functional. Truncated ArfA could be more active than full- length protein (PubMed:21435036). {ECO 0000305|PubMed:21435036}. # Organism ARFA_ECOLI Escherichia coli (strain K12) # PIR I67891 I67891 # Pfam PF03889 DUF331 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ARFA_ECOLI Alternative ribosome-rescue factor A # RefSeq WP_000092696 NZ_LN832404.1 # RefSeq YP_588467 NC_000913.3 # SIMILARITY Belongs to the alternative ribosome-rescue factor A family. {ECO 0000305}. # SUBUNIT Interacts with the 50S ribosomal subunit. {ECO:0000269|PubMed 21062370}. # eggNOG COG3036 LUCA # eggNOG ENOG4105VCN Bacteria BLAST swissprot:ARFA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARFA_ECOLI BioCyc ECOL316407:JW3253-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3253-MONOMER BioCyc EcoCyc:MONOMER0-2687 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2687 COG COG3036 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3036 DOI 10.1016/0378-1119(94)90847-8 http://dx.doi.org/10.1016/0378-1119(94)90847-8 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2010.07375.x http://dx.doi.org/10.1111/j.1365-2958.2010.07375.x DOI 10.1111/j.1365-2958.2011.07638.x http://dx.doi.org/10.1111/j.1365-2958.2011.07638.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L29458 http://www.ebi.ac.uk/ena/data/view/L29458 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB1911 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1911 EcoGene EG11968 http://www.ecogene.org/geneInfo.php?eg_id=EG11968 EnsemblBacteria ABD18700 http://www.ensemblgenomes.org/id/ABD18700 EnsemblBacteria ABD18700 http://www.ensemblgenomes.org/id/ABD18700 EnsemblBacteria BAE78000 http://www.ensemblgenomes.org/id/BAE78000 EnsemblBacteria BAE78000 http://www.ensemblgenomes.org/id/BAE78000 EnsemblBacteria BAE78000 http://www.ensemblgenomes.org/id/BAE78000 EnsemblBacteria b4550 http://www.ensemblgenomes.org/id/b4550 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000049 GO_function GO:0043023 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043023 GO_process GO:0072344 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072344 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 1450289 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1450289 HOGENOM HOG000000578 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000000578&db=HOGENOM6 InParanoid P36675 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P36675 InterPro IPR005589 http://www.ebi.ac.uk/interpro/entry/IPR005589 KEGG_Brite ko03012 http://www.genome.jp/dbget-bin/www_bget?ko03012 KEGG_Gene ecj:JW3253 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3253 KEGG_Gene eco:b4550 http://www.genome.jp/dbget-bin/www_bget?eco:b4550 KEGG_Orthology KO:K09890 http://www.genome.jp/dbget-bin/www_bget?KO:K09890 OMA LPLAFWF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LPLAFWF PSORT swissprot:ARFA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARFA_ECOLI PSORT-B swissprot:ARFA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARFA_ECOLI PSORT2 swissprot:ARFA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARFA_ECOLI Pfam PF03889 http://pfam.xfam.org/family/PF03889 Phobius swissprot:ARFA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARFA_ECOLI ProteinModelPortal P36675 http://www.proteinmodelportal.org/query/uniprot/P36675 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21062370 http://www.ncbi.nlm.nih.gov/pubmed/21062370 PubMed 21435036 http://www.ncbi.nlm.nih.gov/pubmed/21435036 PubMed 8063098 http://www.ncbi.nlm.nih.gov/pubmed/8063098 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000092696 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000092696 RefSeq YP_588467 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_588467 STRING 511145.b4550 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4550&targetmode=cogs STRING COG3036 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3036&targetmode=cogs UniProtKB ARFA_ECOLI http://www.uniprot.org/uniprot/ARFA_ECOLI UniProtKB-AC P36675 http://www.uniprot.org/uniprot/P36675 charge swissprot:ARFA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARFA_ECOLI eggNOG COG3036 http://eggnogapi.embl.de/nog_data/html/tree/COG3036 eggNOG ENOG4105VCN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VCN epestfind swissprot:ARFA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARFA_ECOLI garnier swissprot:ARFA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARFA_ECOLI helixturnhelix swissprot:ARFA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARFA_ECOLI hmoment swissprot:ARFA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARFA_ECOLI iep swissprot:ARFA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARFA_ECOLI inforesidue swissprot:ARFA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARFA_ECOLI octanol swissprot:ARFA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARFA_ECOLI pepcoil swissprot:ARFA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARFA_ECOLI pepdigest swissprot:ARFA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARFA_ECOLI pepinfo swissprot:ARFA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARFA_ECOLI pepnet swissprot:ARFA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARFA_ECOLI pepstats swissprot:ARFA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARFA_ECOLI pepwheel swissprot:ARFA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARFA_ECOLI pepwindow swissprot:ARFA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARFA_ECOLI sigcleave swissprot:ARFA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARFA_ECOLI ## Database ID URL or Descriptions # AltName GSPB_ECOLI Protein PinO # AltName GSPB_ECOLI Protein PioO # BioGrid 4261294 169 # EcoGene EG11263 gspB # FUNCTION GSPB_ECOLI Calcium-binding protein that may be required for the initiation of chromosome replication. May play a regulatory role under conditions of derepressed gsp gene expression. {ECO 0000269|PubMed 11118204, ECO 0000269|PubMed 1925011}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006260 DNA replication; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0009058 biosynthetic process # INDUCTION Silenced by the DNA-binding protein H-NS under standard growth conditions. {ECO:0000269|PubMed 11118204}. # KEGG_Brite ko02044 Secretion system # MISCELLANEOUS GSPB_ECOLI Part of a cryptic operon that encodes proteins involved in type II secretion machinery in other organisms, but is not expressed in strain K12. # Organism GSPB_ECOLI Escherichia coli (strain K12) # PATRIC 32122076 VBIEscCol129921_3415 # PIR E65125 QQECRP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GSPB_ECOLI Putative general secretion pathway protein B # RefSeq NP_417781 NC_000913.3 # RefSeq WP_000461450 NZ_LN832404.1 # SUBCELLULAR LOCATION GSPB_ECOLI Cell membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. # eggNOG ENOG4107ACA Bacteria # eggNOG ENOG410Z2ZU LUCA BLAST swissprot:GSPB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GSPB_ECOLI BioCyc ECOL316407:JW3284-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3284-MONOMER BioCyc EcoCyc:EG11263-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11263-MONOMER DOI 10.1016/0092-8674(81)90303-2 http://dx.doi.org/10.1016/0092-8674(81)90303-2 DOI 10.1016/0923-2508(91)90021-2 http://dx.doi.org/10.1016/0923-2508(91)90021-2 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/emboj/19.24.6697 http://dx.doi.org/10.1093/emboj/19.24.6697 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL V00344 http://www.ebi.ac.uk/ena/data/view/V00344 EchoBASE EB1243 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1243 EcoGene EG11263 http://www.ecogene.org/geneInfo.php?eg_id=EG11263 EnsemblBacteria AAC76347 http://www.ensemblgenomes.org/id/AAC76347 EnsemblBacteria AAC76347 http://www.ensemblgenomes.org/id/AAC76347 EnsemblBacteria BAE77969 http://www.ensemblgenomes.org/id/BAE77969 EnsemblBacteria BAE77969 http://www.ensemblgenomes.org/id/BAE77969 EnsemblBacteria BAE77969 http://www.ensemblgenomes.org/id/BAE77969 EnsemblBacteria b3322 http://www.ensemblgenomes.org/id/b3322 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 947826 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947826 HOGENOM HOG000009789 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009789&db=HOGENOM6 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW3284 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3284 KEGG_Gene eco:b3322 http://www.genome.jp/dbget-bin/www_bget?eco:b3322 KEGG_Orthology KO:K02451 http://www.genome.jp/dbget-bin/www_bget?KO:K02451 OMA QSMWHER http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QSMWHER PSORT swissprot:GSPB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GSPB_ECOLI PSORT-B swissprot:GSPB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GSPB_ECOLI PSORT2 swissprot:GSPB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GSPB_ECOLI Phobius swissprot:GSPB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GSPB_ECOLI ProteinModelPortal P03825 http://www.proteinmodelportal.org/query/uniprot/P03825 PubMed 11118204 http://www.ncbi.nlm.nih.gov/pubmed/11118204 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1925011 http://www.ncbi.nlm.nih.gov/pubmed/1925011 PubMed 1938934 http://www.ncbi.nlm.nih.gov/pubmed/1938934 PubMed 7037196 http://www.ncbi.nlm.nih.gov/pubmed/7037196 PubMed 8655552 http://www.ncbi.nlm.nih.gov/pubmed/8655552 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417781 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417781 RefSeq WP_000461450 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000461450 STRING 511145.b3322 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3322&targetmode=cogs UniProtKB GSPB_ECOLI http://www.uniprot.org/uniprot/GSPB_ECOLI UniProtKB-AC P03825 http://www.uniprot.org/uniprot/P03825 charge swissprot:GSPB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GSPB_ECOLI eggNOG ENOG4107ACA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107ACA eggNOG ENOG410Z2ZU http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Z2ZU epestfind swissprot:GSPB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GSPB_ECOLI garnier swissprot:GSPB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GSPB_ECOLI helixturnhelix swissprot:GSPB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GSPB_ECOLI hmoment swissprot:GSPB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GSPB_ECOLI iep swissprot:GSPB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GSPB_ECOLI inforesidue swissprot:GSPB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GSPB_ECOLI octanol swissprot:GSPB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GSPB_ECOLI pepcoil swissprot:GSPB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GSPB_ECOLI pepdigest swissprot:GSPB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GSPB_ECOLI pepinfo swissprot:GSPB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GSPB_ECOLI pepnet swissprot:GSPB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GSPB_ECOLI pepstats swissprot:GSPB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GSPB_ECOLI pepwheel swissprot:GSPB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GSPB_ECOLI pepwindow swissprot:GSPB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GSPB_ECOLI sigcleave swissprot:GSPB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GSPB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260126 22 # EcoGene EG12967 yciO # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003725 double-stranded RNA binding; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # Gene3D 3.90.870.10 -; 1. # InterPro IPR006070 YrdC-like_dom # InterPro IPR017945 DHBP_synth_RibB-like_a/b_dom # KEGG_Brite ko03009 Ribosome biogenesis # KEGG_Brite ko03016 Transfer RNA biogenesis # Organism YCIO_ECOLI Escherichia coli (strain K12) # PATRIC 32117792 VBIEscCol129921_1316 # PDB 1K7J X-ray; 1.40 A; A=1-206 # PDB 1KK9 X-ray; 2.10 A; A=1-206 # PROSITE PS51163 YRDC # Pfam PF01300 Sua5_yciO_yrdC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCIO_ECOLI Uncharacterized protein YciO # RefSeq NP_415783 NC_000913.3 # RefSeq WP_001295575 NZ_LN832404.1 # SIMILARITY Belongs to the SUA5 family. {ECO 0000305}. # SIMILARITY Contains 1 YrdC-like domain. {ECO:0000255|PROSITE- ProRule PRU00518}. # SUPFAM SSF55821 SSF55821 # TIGRFAMs TIGR00057 TIGR00057 # eggNOG COG0009 LUCA # eggNOG ENOG4107RTD Bacteria BLAST swissprot:YCIO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCIO_ECOLI BioCyc ECOL316407:JW5196-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5196-MONOMER BioCyc EcoCyc:G6635-MONOMER http://biocyc.org/getid?id=EcoCyc:G6635-MONOMER COG COG0009 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0009 DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1002/prot.10178 http://dx.doi.org/10.1002/prot.10178 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M38366 http://www.ebi.ac.uk/ena/data/view/M38366 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18111 http://www.ebi.ac.uk/ena/data/view/U18111 EchoBASE EB2796 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2796 EcoGene EG12967 http://www.ecogene.org/geneInfo.php?eg_id=EG12967 EnsemblBacteria AAC74349 http://www.ensemblgenomes.org/id/AAC74349 EnsemblBacteria AAC74349 http://www.ensemblgenomes.org/id/AAC74349 EnsemblBacteria BAA14801 http://www.ensemblgenomes.org/id/BAA14801 EnsemblBacteria BAA14801 http://www.ensemblgenomes.org/id/BAA14801 EnsemblBacteria BAA14801 http://www.ensemblgenomes.org/id/BAA14801 EnsemblBacteria b1267 http://www.ensemblgenomes.org/id/b1267 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003725 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003725 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 Gene3D 3.90.870.10 http://www.cathdb.info/version/latest/superfamily/3.90.870.10 GeneID 945854 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945854 HOGENOM HOG000076162 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000076162&db=HOGENOM6 InParanoid P0AFR4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFR4 InterPro IPR006070 http://www.ebi.ac.uk/interpro/entry/IPR006070 InterPro IPR017945 http://www.ebi.ac.uk/interpro/entry/IPR017945 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW5196 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5196 KEGG_Gene eco:b1267 http://www.genome.jp/dbget-bin/www_bget?eco:b1267 KEGG_Orthology KO:K07566 http://www.genome.jp/dbget-bin/www_bget?KO:K07566 MINT MINT-1308678 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1308678 OMA RGCGDTA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RGCGDTA PDB 1K7J http://www.ebi.ac.uk/pdbe-srv/view/entry/1K7J PDB 1KK9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1KK9 PDBsum 1K7J http://www.ebi.ac.uk/pdbsum/1K7J PDBsum 1KK9 http://www.ebi.ac.uk/pdbsum/1KK9 PROSITE PS51163 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51163 PSORT swissprot:YCIO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCIO_ECOLI PSORT-B swissprot:YCIO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCIO_ECOLI PSORT2 swissprot:YCIO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCIO_ECOLI Pfam PF01300 http://pfam.xfam.org/family/PF01300 Phobius swissprot:YCIO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCIO_ECOLI PhylomeDB P0AFR4 http://phylomedb.org/?seqid=P0AFR4 ProteinModelPortal P0AFR4 http://www.proteinmodelportal.org/query/uniprot/P0AFR4 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 12211024 http://www.ncbi.nlm.nih.gov/pubmed/12211024 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6385993 http://www.ncbi.nlm.nih.gov/pubmed/6385993 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415783 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415783 RefSeq WP_001295575 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295575 SMR P0AFR4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFR4 STRING 511145.b1267 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1267&targetmode=cogs STRING COG0009 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0009&targetmode=cogs SUPFAM SSF55821 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55821 TIGRFAMs TIGR00057 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00057 UniProtKB YCIO_ECOLI http://www.uniprot.org/uniprot/YCIO_ECOLI UniProtKB-AC P0AFR4 http://www.uniprot.org/uniprot/P0AFR4 charge swissprot:YCIO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCIO_ECOLI eggNOG COG0009 http://eggnogapi.embl.de/nog_data/html/tree/COG0009 eggNOG ENOG4107RTD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107RTD epestfind swissprot:YCIO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCIO_ECOLI garnier swissprot:YCIO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCIO_ECOLI helixturnhelix swissprot:YCIO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCIO_ECOLI hmoment swissprot:YCIO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCIO_ECOLI iep swissprot:YCIO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCIO_ECOLI inforesidue swissprot:YCIO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCIO_ECOLI octanol swissprot:YCIO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCIO_ECOLI pepcoil swissprot:YCIO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCIO_ECOLI pepdigest swissprot:YCIO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCIO_ECOLI pepinfo swissprot:YCIO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCIO_ECOLI pepnet swissprot:YCIO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCIO_ECOLI pepstats swissprot:YCIO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCIO_ECOLI pepwheel swissprot:YCIO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCIO_ECOLI pepwindow swissprot:YCIO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCIO_ECOLI sigcleave swissprot:YCIO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCIO_ECOLI ## Database ID URL or Descriptions # AltName NUOH_ECOLI NADH dehydrogenase I subunit H # AltName NUOH_ECOLI NDH-1 subunit H # AltName NUOH_ECOLI NUO8 # BioGrid 4260511 24 # CATALYTIC ACTIVITY NUOH_ECOLI NADH + a quinone = NAD(+) + a quinol. # EcoGene EG12088 nuoH # FUNCTION NUOH_ECOLI NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0030964 NADH dehydrogenase complex; IDA:EcoliWiki. # GO_component GO:0045272 plasma membrane respiratory chain complex I; IDA:EcoCyc. # GO_function GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; IEA:UniProtKB-HAMAP. # GO_function GO:0048038 quinone binding; IEA:UniProtKB-KW. # GO_process GO:0009060 aerobic respiration; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006091 generation of precursor metabolites and energy # HAMAP MF_01350 NDH1_NuoH # InterPro IPR001694 NADH_UbQ_OxRdtase_su1/FPO # InterPro IPR018086 NADH_UbQ_OxRdtase_su1_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00190 Oxidative phosphorylation # KEGG_Pathway ko00910 Nitrogen metabolism # Organism NUOH_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11432 PTHR11432 # PATRIC 32119931 VBIEscCol129921_2375 # PIR H64999 H64999 # PROSITE PS00667 COMPLEX1_ND1_1 # PROSITE PS00668 COMPLEX1_ND1_2 # Pfam PF00146 NADHdh # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NUOH_ECOLI NADH-quinone oxidoreductase subunit H # RefSeq NP_416785 NC_000913.3 # RefSeq WP_000118507 NZ_LN832404.1 # SIMILARITY Belongs to the complex I subunit 1 family. {ECO 0000305}. # SUBCELLULAR LOCATION NUOH_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT NUOH_ECOLI NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex. # TCDB 3.D.1.1 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family # eggNOG COG1005 LUCA # eggNOG ENOG4105CMZ Bacteria BLAST swissprot:NUOH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NUOH_ECOLI BioCyc ECOL316407:JW2277-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2277-MONOMER BioCyc EcoCyc:NUOH-MONOMER http://biocyc.org/getid?id=EcoCyc:NUOH-MONOMER BioCyc MetaCyc:NUOH-MONOMER http://biocyc.org/getid?id=MetaCyc:NUOH-MONOMER COG COG1005 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1005 DOI 10.1006/jmbi.1993.1488 http://dx.doi.org/10.1006/jmbi.1993.1488 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.6.5.11 http://www.genome.jp/dbget-bin/www_bget?EC:1.6.5.11 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X68301 http://www.ebi.ac.uk/ena/data/view/X68301 ENZYME 1.6.5.11 http://enzyme.expasy.org/EC/1.6.5.11 EchoBASE EB2012 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2012 EcoGene EG12088 http://www.ecogene.org/geneInfo.php?eg_id=EG12088 EnsemblBacteria AAC75342 http://www.ensemblgenomes.org/id/AAC75342 EnsemblBacteria AAC75342 http://www.ensemblgenomes.org/id/AAC75342 EnsemblBacteria BAA16110 http://www.ensemblgenomes.org/id/BAA16110 EnsemblBacteria BAA16110 http://www.ensemblgenomes.org/id/BAA16110 EnsemblBacteria BAA16110 http://www.ensemblgenomes.org/id/BAA16110 EnsemblBacteria b2282 http://www.ensemblgenomes.org/id/b2282 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0030964 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030964 GO_component GO:0045272 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045272 GO_function GO:0016655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016655 GO_function GO:0048038 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048038 GO_process GO:0009060 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009060 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GeneID 946761 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946761 HAMAP MF_01350 http://hamap.expasy.org/unirule/MF_01350 HOGENOM HOG000228276 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000228276&db=HOGENOM6 InParanoid P0AFD4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFD4 IntAct P0AFD4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFD4* IntEnz 1.6.5.11 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.6.5.11 InterPro IPR001694 http://www.ebi.ac.uk/interpro/entry/IPR001694 InterPro IPR018086 http://www.ebi.ac.uk/interpro/entry/IPR018086 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2277 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2277 KEGG_Gene eco:b2282 http://www.genome.jp/dbget-bin/www_bget?eco:b2282 KEGG_Orthology KO:K00337 http://www.genome.jp/dbget-bin/www_bget?KO:K00337 KEGG_Pathway ko00190 http://www.genome.jp/kegg-bin/show_pathway?ko00190 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Reaction rn:R02166 http://www.genome.jp/dbget-bin/www_bget?rn:R02166 OMA LDLGWKF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LDLGWKF PANTHER PTHR11432 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11432 PROSITE PS00667 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00667 PROSITE PS00668 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00668 PSORT swissprot:NUOH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NUOH_ECOLI PSORT-B swissprot:NUOH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NUOH_ECOLI PSORT2 swissprot:NUOH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NUOH_ECOLI Pfam PF00146 http://pfam.xfam.org/family/PF00146 Phobius swissprot:NUOH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NUOH_ECOLI PhylomeDB P0AFD4 http://phylomedb.org/?seqid=P0AFD4 ProteinModelPortal P0AFD4 http://www.proteinmodelportal.org/query/uniprot/P0AFD4 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7690854 http://www.ncbi.nlm.nih.gov/pubmed/7690854 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416785 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416785 RefSeq WP_000118507 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000118507 STRING 511145.b2282 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2282&targetmode=cogs STRING COG1005 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1005&targetmode=cogs TCDB 3.D.1.1 http://www.tcdb.org/search/result.php?tc=3.D.1.1 UniProtKB NUOH_ECOLI http://www.uniprot.org/uniprot/NUOH_ECOLI UniProtKB-AC P0AFD4 http://www.uniprot.org/uniprot/P0AFD4 charge swissprot:NUOH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NUOH_ECOLI eggNOG COG1005 http://eggnogapi.embl.de/nog_data/html/tree/COG1005 eggNOG ENOG4105CMZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CMZ epestfind swissprot:NUOH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NUOH_ECOLI garnier swissprot:NUOH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NUOH_ECOLI helixturnhelix swissprot:NUOH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NUOH_ECOLI hmoment swissprot:NUOH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NUOH_ECOLI iep swissprot:NUOH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NUOH_ECOLI inforesidue swissprot:NUOH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NUOH_ECOLI octanol swissprot:NUOH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NUOH_ECOLI pepcoil swissprot:NUOH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NUOH_ECOLI pepdigest swissprot:NUOH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NUOH_ECOLI pepinfo swissprot:NUOH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NUOH_ECOLI pepnet swissprot:NUOH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NUOH_ECOLI pepstats swissprot:NUOH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NUOH_ECOLI pepwheel swissprot:NUOH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NUOH_ECOLI pepwindow swissprot:NUOH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NUOH_ECOLI sigcleave swissprot:NUOH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NUOH_ECOLI ## Database ID URL or Descriptions # AltName CLPP_ECOLI Caseinolytic protease # AltName CLPP_ECOLI Heat shock protein F21.5 # AltName CLPP_ECOLI Protease Ti # AltName Endopeptidase Clp {ECO:0000255|HAMAP-Rule MF_00444} # BIOPHYSICOCHEMICAL PROPERTIES CLPP_ECOLI Kinetic parameters KM=4.4 mM for N-succinyl-Leu-Tyr-7-amino-4-methyl-coumarin (N- succinyl-Leu-Tyr-AMC) {ECO 0000269|PubMed 16406682, ECO 0000269|PubMed 20637416}; KM=1.0 mM for N-succinyl-Leu-Tyr-AMC {ECO 0000269|PubMed 16406682, ECO 0000269|PubMed 20637416}; # BioGrid 4260736 437 # CATALYTIC ACTIVITY Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs). {ECO:0000255|HAMAP- Rule MF_00444}. # DISRUPTION PHENOTYPE CLPP_ECOLI Cells undergo an apoptotic-like death upon DNA damage characterized by membrane depolarization (PubMed 22412352). Decreased persister cell formation upon antibotic challenge probably due to increased levels of MazF toxin (PubMed 24375411). {ECO 0000269|PubMed 22412352, ECO 0000269|PubMed 24375411}. # DOMAIN CLPP_ECOLI The N-terminus (residues 17-34) interact with ClpA and ClpX. {ECO 0000269|PubMed 16406682}. # ENZYME REGULATION Inhibited by benzyloxycarbonyl leucyltyrosine chloromethylketone (Z-LY-CMK). {ECO:0000269|PubMed 16682229}. # EcoGene EG10158 clpP # FUNCTION CLPP_ECOLI Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. May play the role of a master protease which is attracted to different substrates by different specificity factors such as ClpA or ClpX. Participates in the final steps of RseA-sigma-E degradation, liberating sigma-E to induce the extracytoplasmic-stress response. Degrades antitoxin MazE (PubMed 24375411). {ECO 0000255|HAMAP- Rule MF_00444, ECO 0000269|PubMed 12941278, ECO 0000269|PubMed 15371343, ECO 0000269|PubMed 24375411}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0004176 ATP-dependent peptidase activity; IDA:CACAO. # GO_function GO:0004252 serine-type endopeptidase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0008236 serine-type peptidase activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IPI:EcoCyc. # GO_process GO:0006515 misfolded or incompletely synthesized protein catabolic process; IDA:MGI. # GO_process GO:0009266 response to temperature stimulus; EXP:EcoCyc. # GO_process GO:0009408 response to heat; IEP:EcoliWiki. # GO_process GO:0010498 proteasomal protein catabolic process; IMP:CACAO. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0016887 ATPase activity # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # Gene3D 3.90.226.10 -; 1. # HAMAP MF_00444 ClpP # INDUCTION By heat shock. Part of the clpP-clpX operon. {ECO:0000269|PubMed 8093059}. # INTERACTION CLPP_ECOLI Self; NbExp=3; IntAct=EBI-370625, EBI-370625; P0ABH9 clpA; NbExp=3; IntAct=EBI-370625, EBI-546140; # IntAct P0A6G7 67 # InterPro IPR001907 ClpP # InterPro IPR018215 ClpP_Ser_AS # InterPro IPR023562 ClpP/TepA # InterPro IPR029045 ClpP/crotonase-like_dom # InterPro IPR033135 ClpP_His_AS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # KEGG_Pathway ko04112 Cell cycle - Caulobacter # MISCELLANEOUS Acyldepsipeptide antibiotics bind in the ClpA or ClpX binding-sites, rendering the enzyme ATP-independent and indiscriminate, thus killing cells. {ECO:0000305|PubMed 20851345}. # Organism CLPP_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10381 PTHR10381 # PATRIC 32116027 VBIEscCol129921_0455 # PDB 1TYF X-ray; 2.30 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N=15-207 # PDB 1YG6 X-ray; 1.90 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N=15-207 # PDB 1YG8 X-ray; 2.60 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X/Y/Z/a/b=18-207 # PDB 2FZS X-ray; 1.90 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N=15-207 # PDB 3HLN X-ray; 3.20 A; 1/2/A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X/Y/Z=15-207 # PDB 3MT6 X-ray; 1.90 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X/Y/Z/a/b=1-207 # PIR B36575 B36575 # PRINTS PR00127 CLPPROTEASEP # PROSITE PS00381 CLP_PROTEASE_SER # PROSITE PS00382 CLP_PROTEASE_HIS # Pfam PF00574 CLP_protease # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ATP-dependent Clp protease proteolytic subunit {ECO:0000255|HAMAP-Rule MF_00444} # RefSeq NP_414971 NC_000913.3 # RefSeq WP_000122253 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase S14 family. {ECO:0000255|HAMAP-Rule MF_00444}. # SUBCELLULAR LOCATION CLPP_ECOLI Cytoplasm. # SUBUNIT CLPP_ECOLI Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. Component of the ClpAP and ClpXP complexes. {ECO 0000255|HAMAP-Rule MF_00444, ECO 0000269|PubMed 16406682, ECO 0000269|PubMed 16682229, ECO 0000269|PubMed 20637416, ECO 0000269|PubMed 20851345, ECO 0000269|PubMed 9390554}. # SUPFAM SSF52096 SSF52096 # TIGRFAMs TIGR00493 clpP # eggNOG COG0740 LUCA # eggNOG ENOG4105CCQ Bacteria BLAST swissprot:CLPP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CLPP_ECOLI BioCyc ECOL316407:JW0427-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0427-MONOMER BioCyc EcoCyc:EG10158-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10158-MONOMER BioCyc MetaCyc:EG10158-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10158-MONOMER COG COG0740 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0740 DIP DIP-31838N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31838N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/bbrc.1994.2253 http://dx.doi.org/10.1006/bbrc.1994.2253 DOI 10.1006/jmbi.1996.0499 http://dx.doi.org/10.1006/jmbi.1996.0499 DOI 10.1016/S0092-8674(00)80431-6 http://dx.doi.org/10.1016/S0092-8674(00)80431-6 DOI 10.1016/S0092-8674(03)00612-3 http://dx.doi.org/10.1016/S0092-8674(03)00612-3 DOI 10.1016/j.chembiol.2010.07.008 http://dx.doi.org/10.1016/j.chembiol.2010.07.008 DOI 10.1016/j.jsb.2005.09.011 http://dx.doi.org/10.1016/j.jsb.2005.09.011 DOI 10.1016/j.jsb.2006.03.013 http://dx.doi.org/10.1016/j.jsb.2006.03.013 DOI 10.1016/j.str.2010.04.008 http://dx.doi.org/10.1016/j.str.2010.04.008 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M113.510511 http://dx.doi.org/10.1074/jbc.M113.510511 DOI 10.1101/gad.1240104 http://dx.doi.org/10.1101/gad.1240104 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pbio.1001281 http://dx.doi.org/10.1371/journal.pbio.1001281 EC_number EC:3.4.21.92 {ECO:0000255|HAMAP-Rule:MF_00444} http://www.genome.jp/dbget-bin/www_bget?EC:3.4.21.92 {ECO:0000255|HAMAP-Rule:MF_00444} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J05534 http://www.ebi.ac.uk/ena/data/view/J05534 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 ENZYME 3.4.21.92 {ECO:0000255|HAMAP-Rule:MF_00444} http://enzyme.expasy.org/EC/3.4.21.92 {ECO:0000255|HAMAP-Rule:MF_00444} EchoBASE EB0156 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0156 EcoGene EG10158 http://www.ecogene.org/geneInfo.php?eg_id=EG10158 EnsemblBacteria AAC73540 http://www.ensemblgenomes.org/id/AAC73540 EnsemblBacteria AAC73540 http://www.ensemblgenomes.org/id/AAC73540 EnsemblBacteria BAE76217 http://www.ensemblgenomes.org/id/BAE76217 EnsemblBacteria BAE76217 http://www.ensemblgenomes.org/id/BAE76217 EnsemblBacteria BAE76217 http://www.ensemblgenomes.org/id/BAE76217 EnsemblBacteria b0437 http://www.ensemblgenomes.org/id/b0437 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0004176 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004176 GO_function GO:0004252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004252 GO_function GO:0008236 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008236 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0006515 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006515 GO_process GO:0009266 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009266 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GO_process GO:0010498 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010498 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 3.90.226.10 http://www.cathdb.info/version/latest/superfamily/3.90.226.10 GeneID 945082 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945082 HAMAP MF_00444 http://hamap.expasy.org/unirule/MF_00444 HOGENOM HOG000285833 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000285833&db=HOGENOM6 InParanoid P0A6G7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6G7 IntAct P0A6G7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6G7* IntEnz 3.4.21.92 {ECO:0000255|HAMAP-Rule:MF_00444} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.21.92 {ECO:0000255|HAMAP-Rule:MF_00444} InterPro IPR001907 http://www.ebi.ac.uk/interpro/entry/IPR001907 InterPro IPR018215 http://www.ebi.ac.uk/interpro/entry/IPR018215 InterPro IPR023562 http://www.ebi.ac.uk/interpro/entry/IPR023562 InterPro IPR029045 http://www.ebi.ac.uk/interpro/entry/IPR029045 InterPro IPR033135 http://www.ebi.ac.uk/interpro/entry/IPR033135 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW0427 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0427 KEGG_Gene eco:b0437 http://www.genome.jp/dbget-bin/www_bget?eco:b0437 KEGG_Orthology KO:K01358 http://www.genome.jp/dbget-bin/www_bget?KO:K01358 KEGG_Pathway ko04112 http://www.genome.jp/kegg-bin/show_pathway?ko04112 OMA ARMNELM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ARMNELM PANTHER PTHR10381 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10381 PDB 1TYF http://www.ebi.ac.uk/pdbe-srv/view/entry/1TYF PDB 1YG6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1YG6 PDB 1YG8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1YG8 PDB 2FZS http://www.ebi.ac.uk/pdbe-srv/view/entry/2FZS PDB 3HLN http://www.ebi.ac.uk/pdbe-srv/view/entry/3HLN PDB 3MT6 http://www.ebi.ac.uk/pdbe-srv/view/entry/3MT6 PDBsum 1TYF http://www.ebi.ac.uk/pdbsum/1TYF PDBsum 1YG6 http://www.ebi.ac.uk/pdbsum/1YG6 PDBsum 1YG8 http://www.ebi.ac.uk/pdbsum/1YG8 PDBsum 2FZS http://www.ebi.ac.uk/pdbsum/2FZS PDBsum 3HLN http://www.ebi.ac.uk/pdbsum/3HLN PDBsum 3MT6 http://www.ebi.ac.uk/pdbsum/3MT6 PRINTS PR00127 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00127 PROSITE PS00381 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00381 PROSITE PS00382 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00382 PSORT swissprot:CLPP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CLPP_ECOLI PSORT-B swissprot:CLPP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CLPP_ECOLI PSORT2 swissprot:CLPP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CLPP_ECOLI Pfam PF00574 http://pfam.xfam.org/family/PF00574 Phobius swissprot:CLPP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CLPP_ECOLI PhylomeDB P0A6G7 http://phylomedb.org/?seqid=P0A6G7 ProteinModelPortal P0A6G7 http://www.proteinmodelportal.org/query/uniprot/P0A6G7 PubMed 12941278 http://www.ncbi.nlm.nih.gov/pubmed/12941278 PubMed 15371343 http://www.ncbi.nlm.nih.gov/pubmed/15371343 PubMed 16406682 http://www.ncbi.nlm.nih.gov/pubmed/16406682 PubMed 16682229 http://www.ncbi.nlm.nih.gov/pubmed/16682229 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20637416 http://www.ncbi.nlm.nih.gov/pubmed/20637416 PubMed 20851345 http://www.ncbi.nlm.nih.gov/pubmed/20851345 PubMed 2197275 http://www.ncbi.nlm.nih.gov/pubmed/2197275 PubMed 2211522 http://www.ncbi.nlm.nih.gov/pubmed/2211522 PubMed 22412352 http://www.ncbi.nlm.nih.gov/pubmed/22412352 PubMed 24375411 http://www.ncbi.nlm.nih.gov/pubmed/24375411 PubMed 8093059 http://www.ncbi.nlm.nih.gov/pubmed/8093059 PubMed 8407953 http://www.ncbi.nlm.nih.gov/pubmed/8407953 PubMed 8831780 http://www.ncbi.nlm.nih.gov/pubmed/8831780 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9390554 http://www.ncbi.nlm.nih.gov/pubmed/9390554 RefSeq NP_414971 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414971 RefSeq WP_000122253 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000122253 SMR P0A6G7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6G7 STRING 511145.b0437 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0437&targetmode=cogs STRING COG0740 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0740&targetmode=cogs SUPFAM SSF52096 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52096 SWISS-2DPAGE P0A6G7 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A6G7 TIGRFAMs TIGR00493 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00493 UniProtKB CLPP_ECOLI http://www.uniprot.org/uniprot/CLPP_ECOLI UniProtKB-AC P0A6G7 http://www.uniprot.org/uniprot/P0A6G7 charge swissprot:CLPP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CLPP_ECOLI eggNOG COG0740 http://eggnogapi.embl.de/nog_data/html/tree/COG0740 eggNOG ENOG4105CCQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CCQ epestfind swissprot:CLPP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CLPP_ECOLI garnier swissprot:CLPP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CLPP_ECOLI helixturnhelix swissprot:CLPP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CLPP_ECOLI hmoment swissprot:CLPP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CLPP_ECOLI iep swissprot:CLPP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CLPP_ECOLI inforesidue swissprot:CLPP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CLPP_ECOLI octanol swissprot:CLPP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CLPP_ECOLI pepcoil swissprot:CLPP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CLPP_ECOLI pepdigest swissprot:CLPP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CLPP_ECOLI pepinfo swissprot:CLPP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CLPP_ECOLI pepnet swissprot:CLPP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CLPP_ECOLI pepstats swissprot:CLPP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CLPP_ECOLI pepwheel swissprot:CLPP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CLPP_ECOLI pepwindow swissprot:CLPP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CLPP_ECOLI sigcleave swissprot:CLPP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CLPP_ECOLI ## Database ID URL or Descriptions # AltName GUDP_ECOLI D-glucarate permease # BioGrid 4263242 14 # CDD cd06174 MFS # EcoGene EG13169 gudP # FUNCTION GUDP_ECOLI Uptake of D-glucarate. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IBA:GO_Central. # GO_function GO:0022857 transmembrane transporter activity; IBA:GO_Central. # GO_process GO:0006820 anion transport; IBA:GO_Central. # GO_process GO:0055085 transmembrane transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # InterPro IPR000849 Sugar_P_transporter # InterPro IPR004744 Dgal_transporter # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # KEGG_Brite ko02000 Transporters # Organism GUDP_ECOLI Escherichia coli (strain K12) # PATRIC 32120994 VBIEscCol129921_2889 # PIR A65061 A65061 # PIRSF PIRSF002808 Hexose_phosphate_transp # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GUDP_ECOLI Probable glucarate transporter # RefSeq NP_417269 NC_000913.3 # RefSeq WP_000097072 NZ_LN832404.1 # SIMILARITY Belongs to the major facilitator superfamily. Phthalate permease family. {ECO 0000305}. # SUBCELLULAR LOCATION GUDP_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF103473 SSF103473 # TIGRFAMs TIGR00893 2A0114 # eggNOG ENOG4105DJB Bacteria # eggNOG ENOG410XPWC LUCA BLAST swissprot:GUDP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GUDP_ECOLI BioCyc ECOL316407:JW2760-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2760-MONOMER BioCyc EcoCyc:B2789-MONOMER http://biocyc.org/getid?id=EcoCyc:B2789-MONOMER BioCyc MetaCyc:B2789-MONOMER http://biocyc.org/getid?id=MetaCyc:B2789-MONOMER COG COG0477 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0477 DOI 10.1021/bi981124f http://dx.doi.org/10.1021/bi981124f DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.9.2672-2674.2000 http://dx.doi.org/10.1128/JB.182.9.2672-2674.2000 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 EchoBASE EB2961 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2961 EcoGene EG13169 http://www.ecogene.org/geneInfo.php?eg_id=EG13169 EnsemblBacteria AAC75831 http://www.ensemblgenomes.org/id/AAC75831 EnsemblBacteria AAC75831 http://www.ensemblgenomes.org/id/AAC75831 EnsemblBacteria BAE76861 http://www.ensemblgenomes.org/id/BAE76861 EnsemblBacteria BAE76861 http://www.ensemblgenomes.org/id/BAE76861 EnsemblBacteria BAE76861 http://www.ensemblgenomes.org/id/BAE76861 EnsemblBacteria b2789 http://www.ensemblgenomes.org/id/b2789 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GO_process GO:0006820 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006820 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 947265 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947265 HOGENOM HOG000113642 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000113642&db=HOGENOM6 InParanoid Q46916 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46916 InterPro IPR000849 http://www.ebi.ac.uk/interpro/entry/IPR000849 InterPro IPR004744 http://www.ebi.ac.uk/interpro/entry/IPR004744 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2760 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2760 KEGG_Gene eco:b2789 http://www.genome.jp/dbget-bin/www_bget?eco:b2789 KEGG_Orthology KO:K03535 http://www.genome.jp/dbget-bin/www_bget?KO:K03535 OMA HHVYLWL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HHVYLWL PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:GUDP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GUDP_ECOLI PSORT-B swissprot:GUDP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GUDP_ECOLI PSORT2 swissprot:GUDP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GUDP_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:GUDP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GUDP_ECOLI PhylomeDB Q46916 http://phylomedb.org/?seqid=Q46916 ProteinModelPortal Q46916 http://www.proteinmodelportal.org/query/uniprot/Q46916 PubMed 10762278 http://www.ncbi.nlm.nih.gov/pubmed/10762278 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9772162 http://www.ncbi.nlm.nih.gov/pubmed/9772162 RefSeq NP_417269 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417269 RefSeq WP_000097072 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000097072 STRING 511145.b2789 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2789&targetmode=cogs STRING COG0477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0477&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TIGRFAMs TIGR00893 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00893 UniProtKB GUDP_ECOLI http://www.uniprot.org/uniprot/GUDP_ECOLI UniProtKB-AC Q46916 http://www.uniprot.org/uniprot/Q46916 charge swissprot:GUDP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GUDP_ECOLI eggNOG ENOG4105DJB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DJB eggNOG ENOG410XPWC http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPWC epestfind swissprot:GUDP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GUDP_ECOLI garnier swissprot:GUDP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GUDP_ECOLI helixturnhelix swissprot:GUDP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GUDP_ECOLI hmoment swissprot:GUDP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GUDP_ECOLI iep swissprot:GUDP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GUDP_ECOLI inforesidue swissprot:GUDP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GUDP_ECOLI octanol swissprot:GUDP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GUDP_ECOLI pepcoil swissprot:GUDP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GUDP_ECOLI pepdigest swissprot:GUDP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GUDP_ECOLI pepinfo swissprot:GUDP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GUDP_ECOLI pepnet swissprot:GUDP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GUDP_ECOLI pepstats swissprot:GUDP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GUDP_ECOLI pepwheel swissprot:GUDP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GUDP_ECOLI pepwindow swissprot:GUDP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GUDP_ECOLI sigcleave swissprot:GUDP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GUDP_ECOLI ## Database ID URL or Descriptions # BioGrid 4260524 10 # EcoGene EG12124 hisJ # FUNCTION HISJ_ECOLI Part of the histidine permease ABC transporter. Binds histidine. Interacts with HisQMP and stimulates ATPase activity of HisP, which results in histidine translocation (By similarity). {ECO 0000250}. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0005215 transporter activity; IEA:InterPro. # GO_process GO:0006865 amino acid transport; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006810 transport # IntAct P0AEU0 7 # InterPro IPR001638 Solute-binding_3/MltF_N # InterPro IPR005768 Lys_Arg_Orn-bd # InterPro IPR018313 SBP_3_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00226 Histidine transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism HISJ_ECOLI Escherichia coli (strain K12) # PATRIC 32119989 VBIEscCol129921_2404 # PDB 1HSL X-ray; 1.89 A; A/B=28-260 # PIR C65003 C65003 # PROSITE PS01039 SBP_BACTERIAL_3 # Pfam PF00497 SBP_bac_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HISJ_ECOLI Histidine-binding periplasmic protein # RefSeq NP_416812 NC_000913.3 # RefSeq WP_000737621 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial solute-binding protein 3 family. {ECO 0000305}. # SMART SM00062 PBPb # SUBCELLULAR LOCATION HISJ_ECOLI Periplasm. # SUBUNIT The complex is composed of two ATP-binding proteins (HisP), two transmembrane proteins (HisM and HisQ) and a solute- binding protein (HisJ). {ECO 0000250}. # TCDB 3.A.1.3.29 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR01096 3A0103s03R # eggNOG COG0834 LUCA # eggNOG ENOG4105E89 Bacteria BLAST swissprot:HISJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HISJ_ECOLI BioCyc ECOL316407:JW2306-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2306-MONOMER BioCyc EcoCyc:HISJ-MONOMER http://biocyc.org/getid?id=EcoCyc:HISJ-MONOMER COG COG0834 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0834 DIP DIP-9908N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9908N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1998.1726 http://dx.doi.org/10.1006/jmbi.1998.1726 DOI 10.1021/bi00182a004 http://dx.doi.org/10.1021/bi00182a004 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U47027 http://www.ebi.ac.uk/ena/data/view/U47027 EchoBASE EB2045 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2045 EcoGene EG12124 http://www.ecogene.org/geneInfo.php?eg_id=EG12124 EnsemblBacteria AAC75369 http://www.ensemblgenomes.org/id/AAC75369 EnsemblBacteria AAC75369 http://www.ensemblgenomes.org/id/AAC75369 EnsemblBacteria BAA16155 http://www.ensemblgenomes.org/id/BAA16155 EnsemblBacteria BAA16155 http://www.ensemblgenomes.org/id/BAA16155 EnsemblBacteria BAA16155 http://www.ensemblgenomes.org/id/BAA16155 EnsemblBacteria b2309 http://www.ensemblgenomes.org/id/b2309 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_process GO:0006865 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 945309 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945309 HOGENOM HOG000031896 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000031896&db=HOGENOM6 InParanoid P0AEU0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEU0 IntAct P0AEU0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEU0* InterPro IPR001638 http://www.ebi.ac.uk/interpro/entry/IPR001638 InterPro IPR005768 http://www.ebi.ac.uk/interpro/entry/IPR005768 InterPro IPR018313 http://www.ebi.ac.uk/interpro/entry/IPR018313 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2306 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2306 KEGG_Gene eco:b2309 http://www.genome.jp/dbget-bin/www_bget?eco:b2309 KEGG_Orthology KO:K10014 http://www.genome.jp/dbget-bin/www_bget?KO:K10014 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA IPYQNQD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IPYQNQD PDB 1HSL http://www.ebi.ac.uk/pdbe-srv/view/entry/1HSL PDBsum 1HSL http://www.ebi.ac.uk/pdbsum/1HSL PROSITE PS01039 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01039 PSORT swissprot:HISJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HISJ_ECOLI PSORT-B swissprot:HISJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HISJ_ECOLI PSORT2 swissprot:HISJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HISJ_ECOLI Pfam PF00497 http://pfam.xfam.org/family/PF00497 Phobius swissprot:HISJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HISJ_ECOLI PhylomeDB P0AEU0 http://phylomedb.org/?seqid=P0AEU0 ProteinModelPortal P0AEU0 http://www.proteinmodelportal.org/query/uniprot/P0AEU0 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8161536 http://www.ncbi.nlm.nih.gov/pubmed/8161536 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 RefSeq NP_416812 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416812 RefSeq WP_000737621 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000737621 SMART SM00062 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00062 SMR P0AEU0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEU0 STRING 511145.b2309 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2309&targetmode=cogs STRING COG0834 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0834&targetmode=cogs SWISS-2DPAGE P0AEU0 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AEU0 TCDB 3.A.1.3.29 http://www.tcdb.org/search/result.php?tc=3.A.1.3.29 TIGRFAMs TIGR01096 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01096 UniProtKB HISJ_ECOLI http://www.uniprot.org/uniprot/HISJ_ECOLI UniProtKB-AC P0AEU0 http://www.uniprot.org/uniprot/P0AEU0 charge swissprot:HISJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HISJ_ECOLI eggNOG COG0834 http://eggnogapi.embl.de/nog_data/html/tree/COG0834 eggNOG ENOG4105E89 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E89 epestfind swissprot:HISJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HISJ_ECOLI garnier swissprot:HISJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HISJ_ECOLI helixturnhelix swissprot:HISJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HISJ_ECOLI hmoment swissprot:HISJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HISJ_ECOLI iep swissprot:HISJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HISJ_ECOLI inforesidue swissprot:HISJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HISJ_ECOLI octanol swissprot:HISJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HISJ_ECOLI pepcoil swissprot:HISJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HISJ_ECOLI pepdigest swissprot:HISJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HISJ_ECOLI pepinfo swissprot:HISJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HISJ_ECOLI pepnet swissprot:HISJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HISJ_ECOLI pepstats swissprot:HISJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HISJ_ECOLI pepwheel swissprot:HISJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HISJ_ECOLI pepwindow swissprot:HISJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HISJ_ECOLI sigcleave swissprot:HISJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HISJ_ECOLI ## Database ID URL or Descriptions # AltName Phosphotransfer intermediate RcsD {ECO:0000255|HAMAP-Rule MF_00980} # CAUTION Contains a histidine kinase domain, but it seems to be non-functional as the highly conserved histidine residue is missing. {ECO:0000305|PubMed 11309126}. # EcoGene EG12385 rcsD # FUNCTION RCSD_ECOLI Component of the Rcs signaling system, which controls transcription of numerous genes. RcsD is a phosphotransfer intermediate between the sensor kinase RcsC and the response regulator RcsB. It acquires a phosphoryl group from RcsC and transfers it to RcsB. The system controls expression of genes involved in colanic acid capsule synthesis, biofilm formation and cell division. {ECO 0000255|HAMAP-Rule MF_00980, ECO 0000269|PubMed 10564486, ECO 0000269|PubMed 11309126, ECO 0000269|PubMed 11758943, ECO 0000269|PubMed 13129944, ECO 0000269|PubMed 14651646}. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0009927 histidine phosphotransfer kinase activity; IMP:EcoCyc. # GO_function GO:0016774 phosphotransferase activity, carboxyl group as acceptor; IEA:UniProtKB-HAMAP. # GO_process GO:0000160 phosphorelay signal transduction system; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005622 intracellular # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0007165 signal transduction # Gene3D 1.20.120.160 -; 1. # Gene3D 3.30.565.10 -; 1. # HAMAP MF_00980 RcsD # IntAct P39838 4 # InterPro IPR003594 HATPase_C # InterPro IPR005467 His_kinase_dom # InterPro IPR008207 Sig_transdc_His_kin_Hpt_dom # InterPro IPR030861 Ptransferase_RcsD # InterPro IPR032306 RcsD_ABL # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01001 Protein kinases # KEGG_Brite ko02022 M00474 RcsC-RcsD-RcsB (capsule synthesis) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # Organism RCSD_ECOLI Escherichia coli (strain K12) # PATRIC 32119791 VBIEscCol129921_2305 # PDB 1SR2 NMR; -; A=775-890 # PDB 2KX7 NMR; -; A=688-795 # PIR F64991 F64991 # PROSITE PS50109 HIS_KIN # PROSITE PS50894 HPT # PTM RCSD_ECOLI Phosphorylated by RcsC. {ECO 0000305|PubMed 11309126}. # Pfam PF01627 Hpt # Pfam PF02518 HATPase_c # Pfam PF16359 RcsD_ABL # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Phosphotransferase RcsD {ECO:0000255|HAMAP-Rule MF_00980} # RefSeq NP_416720 NC_000913.3 # RefSeq WP_001249081 NZ_LN832404.1 # SEQUENCE CAUTION RCSD_ECOLI Sequence=AAA81025.1; Type=Frameshift; Positions=145, 488; Evidence={ECO 0000305}; Sequence=AAA81026.1; Type=Frameshift; Positions=145, 488; Evidence={ECO 0000305}; Sequence=AAA81027.1; Type=Frameshift; Positions=145, 488; Evidence={ECO 0000305}; Sequence=M28242; Type=Frameshift; Positions=597, 702; Evidence={ECO 0000305}; # SIMILARITY Belongs to the RcsD family. {ECO:0000255|HAMAP- Rule MF_00980}. # SIMILARITY Contains 1 HPt domain. {ECO:0000255|HAMAP- Rule MF_00980}. # SIMILARITY Contains 1 histidine kinase domain. {ECO 0000305}. # SMART SM00387 HATPase_c # SUBCELLULAR LOCATION RCSD_ECOLI Cell inner membrane {ECO 0000305|PubMed 11309126}; Multi-pass membrane protein {ECO 0000305|PubMed 11309126}. # SUBUNIT RCSD_ECOLI Interacts with RcsC and RcsB. Has a higher affinity for RcsB than for RcsC. {ECO 0000255|HAMAP-Rule MF_00980, ECO 0000269|PubMed 15476819}. # SUPFAM SSF47226 SSF47226 # SUPFAM SSF55874 SSF55874 # eggNOG COG2198 LUCA # eggNOG ENOG4105E3G Bacteria BLAST swissprot:RCSD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RCSD_ECOLI BioCyc ECOL316407:JW2204-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2204-MONOMER BioCyc EcoCyc:EG12385-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12385-MONOMER DIP DIP-12815N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12815N DOI 10.1016/j.jmb.2004.08.096 http://dx.doi.org/10.1016/j.jmb.2004.08.096 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1999.01605.x http://dx.doi.org/10.1046/j.1365-2958.1999.01605.x DOI 10.1046/j.1365-2958.2001.02393.x http://dx.doi.org/10.1046/j.1365-2958.2001.02393.x DOI 10.1046/j.1365-2958.2003.03815.x http://dx.doi.org/10.1046/j.1365-2958.2003.03815.x DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.185.19.5735-5746.2003 http://dx.doi.org/10.1128/JB.185.19.5735-5746.2003 DOI 10.1271/bbb.65.2364 http://dx.doi.org/10.1271/bbb.65.2364 EC_number EC:2.7.2.- {ECO:0000255|HAMAP-Rule:MF_00980} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.2.- {ECO:0000255|HAMAP-Rule:MF_00980} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M28242 http://www.ebi.ac.uk/ena/data/view/M28242 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U38659 http://www.ebi.ac.uk/ena/data/view/U38659 EMBL U38659 http://www.ebi.ac.uk/ena/data/view/U38659 EMBL U38659 http://www.ebi.ac.uk/ena/data/view/U38659 ENZYME 2.7.2.- {ECO:0000255|HAMAP-Rule:MF_00980} http://enzyme.expasy.org/EC/2.7.2.- {ECO:0000255|HAMAP-Rule:MF_00980} EchoBASE EB2286 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2286 EcoGene EG12385 http://www.ecogene.org/geneInfo.php?eg_id=EG12385 EnsemblBacteria AAC75276 http://www.ensemblgenomes.org/id/AAC75276 EnsemblBacteria AAC75276 http://www.ensemblgenomes.org/id/AAC75276 EnsemblBacteria BAA15999 http://www.ensemblgenomes.org/id/BAA15999 EnsemblBacteria BAA15999 http://www.ensemblgenomes.org/id/BAA15999 EnsemblBacteria BAA15999 http://www.ensemblgenomes.org/id/BAA15999 EnsemblBacteria b2216 http://www.ensemblgenomes.org/id/b2216 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0009927 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009927 GO_function GO:0016774 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016774 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 Gene3D 1.20.120.160 http://www.cathdb.info/version/latest/superfamily/1.20.120.160 Gene3D 3.30.565.10 http://www.cathdb.info/version/latest/superfamily/3.30.565.10 GeneID 946717 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946717 HAMAP MF_00980 http://hamap.expasy.org/unirule/MF_00980 HOGENOM HOG000122289 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122289&db=HOGENOM6 IntAct P39838 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39838* IntEnz 2.7.2.- {ECO:0000255|HAMAP-Rule:MF_00980} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.2.- {ECO:0000255|HAMAP-Rule:MF_00980} InterPro IPR003594 http://www.ebi.ac.uk/interpro/entry/IPR003594 InterPro IPR005467 http://www.ebi.ac.uk/interpro/entry/IPR005467 InterPro IPR008207 http://www.ebi.ac.uk/interpro/entry/IPR008207 InterPro IPR030861 http://www.ebi.ac.uk/interpro/entry/IPR030861 InterPro IPR032306 http://www.ebi.ac.uk/interpro/entry/IPR032306 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01001 http://www.genome.jp/dbget-bin/www_bget?ko01001 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW2204 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2204 KEGG_Gene eco:b2216 http://www.genome.jp/dbget-bin/www_bget?eco:b2216 KEGG_Orthology KO:K07676 http://www.genome.jp/dbget-bin/www_bget?KO:K07676 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 MINT MINT-1304951 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1304951 OMA TWRYATW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TWRYATW PDB 1SR2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1SR2 PDB 2KX7 http://www.ebi.ac.uk/pdbe-srv/view/entry/2KX7 PDBsum 1SR2 http://www.ebi.ac.uk/pdbsum/1SR2 PDBsum 2KX7 http://www.ebi.ac.uk/pdbsum/2KX7 PROSITE PS50109 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50109 PROSITE PS50894 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50894 PSORT swissprot:RCSD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RCSD_ECOLI PSORT-B swissprot:RCSD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RCSD_ECOLI PSORT2 swissprot:RCSD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RCSD_ECOLI Pfam PF01627 http://pfam.xfam.org/family/PF01627 Pfam PF02518 http://pfam.xfam.org/family/PF02518 Pfam PF16359 http://pfam.xfam.org/family/PF16359 Phobius swissprot:RCSD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RCSD_ECOLI ProteinModelPortal P39838 http://www.proteinmodelportal.org/query/uniprot/P39838 PubMed 10564486 http://www.ncbi.nlm.nih.gov/pubmed/10564486 PubMed 11309126 http://www.ncbi.nlm.nih.gov/pubmed/11309126 PubMed 11758943 http://www.ncbi.nlm.nih.gov/pubmed/11758943 PubMed 13129944 http://www.ncbi.nlm.nih.gov/pubmed/13129944 PubMed 14651646 http://www.ncbi.nlm.nih.gov/pubmed/14651646 PubMed 15476819 http://www.ncbi.nlm.nih.gov/pubmed/15476819 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2404948 http://www.ncbi.nlm.nih.gov/pubmed/2404948 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416720 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416720 RefSeq WP_001249081 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001249081 SMART SM00387 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00387 SMR P39838 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39838 STRING 511145.b2216 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2216&targetmode=cogs SUPFAM SSF47226 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47226 SUPFAM SSF55874 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55874 UniProtKB RCSD_ECOLI http://www.uniprot.org/uniprot/RCSD_ECOLI UniProtKB-AC P39838 http://www.uniprot.org/uniprot/P39838 charge swissprot:RCSD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RCSD_ECOLI eggNOG COG2198 http://eggnogapi.embl.de/nog_data/html/tree/COG2198 eggNOG ENOG4105E3G http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E3G epestfind swissprot:RCSD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RCSD_ECOLI garnier swissprot:RCSD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RCSD_ECOLI helixturnhelix swissprot:RCSD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RCSD_ECOLI hmoment swissprot:RCSD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RCSD_ECOLI iep swissprot:RCSD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RCSD_ECOLI inforesidue swissprot:RCSD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RCSD_ECOLI octanol swissprot:RCSD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RCSD_ECOLI pepcoil swissprot:RCSD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RCSD_ECOLI pepdigest swissprot:RCSD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RCSD_ECOLI pepinfo swissprot:RCSD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RCSD_ECOLI pepnet swissprot:RCSD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RCSD_ECOLI pepstats swissprot:RCSD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RCSD_ECOLI pepwheel swissprot:RCSD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RCSD_ECOLI pepwindow swissprot:RCSD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RCSD_ECOLI sigcleave swissprot:RCSD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RCSD_ECOLI ## Database ID URL or Descriptions # BioGrid 4260851 219 # EcoGene EG12264 bcsF # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR019995 Cellulose_BcsF/YhjT # MISCELLANEOUS BCSF_ECOLI Cellulose production is abolished in E.coli K12. # Organism BCSF_ECOLI Escherichia coli (strain K12) # PATRIC 32122540 VBIEscCol129921_3648 # PIR S47759 S47759 # Pfam PF11120 CBP_BcsF # ProDom PD053231 Cellulose_BcsF/YhjT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BCSF_ECOLI Protein BcsF homolog # RefSeq NP_417994 NC_000913.3 # RefSeq WP_000988308 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18515.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SUBCELLULAR LOCATION BCSF_ECOLI Cell membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. # TIGRFAMs TIGR03493 cellullose_BcsF # eggNOG ENOG4105WQA Bacteria # eggNOG ENOG41123GA LUCA BLAST swissprot:BCSF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BCSF_ECOLI BioCyc ECOL316407:JW5663-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5663-MONOMER BioCyc EcoCyc:EG12264-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12264-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2173 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2173 EcoGene EG12264 http://www.ecogene.org/geneInfo.php?eg_id=EG12264 EnsemblBacteria AAC76562 http://www.ensemblgenomes.org/id/AAC76562 EnsemblBacteria AAC76562 http://www.ensemblgenomes.org/id/AAC76562 EnsemblBacteria BAE77758 http://www.ensemblgenomes.org/id/BAE77758 EnsemblBacteria BAE77758 http://www.ensemblgenomes.org/id/BAE77758 EnsemblBacteria BAE77758 http://www.ensemblgenomes.org/id/BAE77758 EnsemblBacteria b3537 http://www.ensemblgenomes.org/id/b3537 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 948059 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948059 HOGENOM HOG000268034 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000268034&db=HOGENOM6 InterPro IPR019995 http://www.ebi.ac.uk/interpro/entry/IPR019995 KEGG_Gene ecj:JW5663 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5663 KEGG_Gene eco:b3537 http://www.genome.jp/dbget-bin/www_bget?eco:b3537 OMA VFCALIF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VFCALIF PSORT swissprot:BCSF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BCSF_ECOLI PSORT-B swissprot:BCSF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BCSF_ECOLI PSORT2 swissprot:BCSF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BCSF_ECOLI Pfam PF11120 http://pfam.xfam.org/family/PF11120 Phobius swissprot:BCSF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BCSF_ECOLI ProteinModelPortal P0ADJ5 http://www.proteinmodelportal.org/query/uniprot/P0ADJ5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417994 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417994 RefSeq WP_000988308 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000988308 STRING 511145.b3537 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3537&targetmode=cogs TIGRFAMs TIGR03493 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03493 UniProtKB BCSF_ECOLI http://www.uniprot.org/uniprot/BCSF_ECOLI UniProtKB-AC P0ADJ5 http://www.uniprot.org/uniprot/P0ADJ5 charge swissprot:BCSF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BCSF_ECOLI eggNOG ENOG4105WQA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105WQA eggNOG ENOG41123GA http://eggnogapi.embl.de/nog_data/html/tree/ENOG41123GA epestfind swissprot:BCSF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BCSF_ECOLI garnier swissprot:BCSF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BCSF_ECOLI helixturnhelix swissprot:BCSF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BCSF_ECOLI hmoment swissprot:BCSF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BCSF_ECOLI iep swissprot:BCSF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BCSF_ECOLI inforesidue swissprot:BCSF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BCSF_ECOLI octanol swissprot:BCSF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BCSF_ECOLI pepcoil swissprot:BCSF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BCSF_ECOLI pepdigest swissprot:BCSF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BCSF_ECOLI pepinfo swissprot:BCSF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BCSF_ECOLI pepnet swissprot:BCSF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BCSF_ECOLI pepstats swissprot:BCSF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BCSF_ECOLI pepwheel swissprot:BCSF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BCSF_ECOLI pepwindow swissprot:BCSF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BCSF_ECOLI sigcleave swissprot:BCSF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BCSF_ECOLI ## Database ID URL or Descriptions # BioGrid 4260539 8 # EcoGene EG12420 yfdC # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0015513 nitrite uptake transmembrane transporter activity; IBA:GO_Central. # GO_process GO:0015707 nitrite transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # Gene3D 1.20.1080.10 -; 1. # InterPro IPR000292 For/NO2_transpt # InterPro IPR023271 Aquaporin-like # Organism YFDC_ECOLI Escherichia coli (strain K12) # PATRIC 32120069 VBIEscCol129921_2444 # PIR A65008 A65008 # Pfam PF01226 Form_Nir_trans # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFDC_ECOLI Inner membrane protein YfdC # RefSeq NP_416849 NC_000913.3 # RefSeq WP_000368140 NZ_LN832404.1 # SUBCELLULAR LOCATION YFDC_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 1.A.16.4 the formate-nitrite transporter (fnt) family # eggNOG COG2116 LUCA # eggNOG ENOG4105S64 Bacteria BLAST swissprot:YFDC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFDC_ECOLI BioCyc ECOL316407:JW2344-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2344-MONOMER BioCyc EcoCyc:G7217-MONOMER http://biocyc.org/getid?id=EcoCyc:G7217-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U11296 http://www.ebi.ac.uk/ena/data/view/U11296 EchoBASE EB2319 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2319 EcoGene EG12420 http://www.ecogene.org/geneInfo.php?eg_id=EG12420 EnsemblBacteria AAC75407 http://www.ensemblgenomes.org/id/AAC75407 EnsemblBacteria AAC75407 http://www.ensemblgenomes.org/id/AAC75407 EnsemblBacteria BAA16207 http://www.ensemblgenomes.org/id/BAA16207 EnsemblBacteria BAA16207 http://www.ensemblgenomes.org/id/BAA16207 EnsemblBacteria BAA16207 http://www.ensemblgenomes.org/id/BAA16207 EnsemblBacteria b2347 http://www.ensemblgenomes.org/id/b2347 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015513 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015513 GO_process GO:0015707 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015707 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 1.20.1080.10 http://www.cathdb.info/version/latest/superfamily/1.20.1080.10 GeneID 944801 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944801 HOGENOM HOG000122534 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122534&db=HOGENOM6 InParanoid P37327 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37327 InterPro IPR000292 http://www.ebi.ac.uk/interpro/entry/IPR000292 InterPro IPR023271 http://www.ebi.ac.uk/interpro/entry/IPR023271 KEGG_Gene ecj:JW2344 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2344 KEGG_Gene eco:b2347 http://www.genome.jp/dbget-bin/www_bget?eco:b2347 OMA GWMIATM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GWMIATM PSORT swissprot:YFDC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFDC_ECOLI PSORT-B swissprot:YFDC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFDC_ECOLI PSORT2 swissprot:YFDC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFDC_ECOLI Pfam PF01226 http://pfam.xfam.org/family/PF01226 Phobius swissprot:YFDC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFDC_ECOLI PhylomeDB P37327 http://phylomedb.org/?seqid=P37327 ProteinModelPortal P37327 http://www.proteinmodelportal.org/query/uniprot/P37327 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416849 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416849 RefSeq WP_000368140 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000368140 STRING 511145.b2347 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2347&targetmode=cogs TCDB 1.A.16.4 http://www.tcdb.org/search/result.php?tc=1.A.16.4 UniProtKB YFDC_ECOLI http://www.uniprot.org/uniprot/YFDC_ECOLI UniProtKB-AC P37327 http://www.uniprot.org/uniprot/P37327 charge swissprot:YFDC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFDC_ECOLI eggNOG COG2116 http://eggnogapi.embl.de/nog_data/html/tree/COG2116 eggNOG ENOG4105S64 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105S64 epestfind swissprot:YFDC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFDC_ECOLI garnier swissprot:YFDC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFDC_ECOLI helixturnhelix swissprot:YFDC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFDC_ECOLI hmoment swissprot:YFDC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFDC_ECOLI iep swissprot:YFDC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFDC_ECOLI inforesidue swissprot:YFDC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFDC_ECOLI octanol swissprot:YFDC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFDC_ECOLI pepcoil swissprot:YFDC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFDC_ECOLI pepdigest swissprot:YFDC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFDC_ECOLI pepinfo swissprot:YFDC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFDC_ECOLI pepnet swissprot:YFDC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFDC_ECOLI pepstats swissprot:YFDC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFDC_ECOLI pepwheel swissprot:YFDC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFDC_ECOLI pepwindow swissprot:YFDC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFDC_ECOLI sigcleave swissprot:YFDC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFDC_ECOLI ## Database ID URL or Descriptions # FUNCTION INSD9_ECOLI Involved in the transposition of the insertion sequence IS2. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006310 DNA recombination; IEA:UniProtKB-KW. # GO_process GO:0015074 DNA integration; IEA:InterPro. # GO_process GO:0032196 transposition; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 3.30.420.10 -; 1. # InterPro IPR001584 Integrase_cat-core # InterPro IPR012337 RNaseH-like_dom # InterPro IPR025948 HTH-like_dom # Organism INSD9_ECOLI Escherichia coli (strain K12) # PATRIC 48661345 VBIEscCol107702_1042 # PROSITE PS50994 INTEGRASE # Pfam PF00665 rve # Pfam PF13276 HTH_21 # RecName INSD9_ECOLI Transposase InsD for insertion element IS2-9 # SIMILARITY Contains 1 integrase catalytic domain. {ECO:0000255|PROSITE-ProRule PRU00457}. # SUPFAM SSF53098 SSF53098 # eggNOG ENOG4108MVM Bacteria # eggNOG ENOG410Z4Y8 LUCA BLAST swissprot:INSD9_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSD9_ECOLI DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EnsemblBacteria BAE76370 http://www.ensemblgenomes.org/id/BAE76370 EnsemblBacteria BAE76370 http://www.ensemblgenomes.org/id/BAE76370 EnsemblBacteria BAE76370 http://www.ensemblgenomes.org/id/BAE76370 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0015074 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015074 GO_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 3.30.420.10 http://www.cathdb.info/version/latest/superfamily/3.30.420.10 InterPro IPR001584 http://www.ebi.ac.uk/interpro/entry/IPR001584 InterPro IPR012337 http://www.ebi.ac.uk/interpro/entry/IPR012337 InterPro IPR025948 http://www.ebi.ac.uk/interpro/entry/IPR025948 KEGG_Gene ecj:JW5899 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5899 PROSITE PS50994 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50994 PSORT swissprot:INSD9_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSD9_ECOLI PSORT-B swissprot:INSD9_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSD9_ECOLI PSORT2 swissprot:INSD9_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSD9_ECOLI Pfam PF00665 http://pfam.xfam.org/family/PF00665 Pfam PF13276 http://pfam.xfam.org/family/PF13276 Phobius swissprot:INSD9_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSD9_ECOLI PhylomeDB P0CF61 http://phylomedb.org/?seqid=P0CF61 ProteinModelPortal P0CF61 http://www.proteinmodelportal.org/query/uniprot/P0CF61 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 SMR P0CF61 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0CF61 STRING 511145.b4273 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4273&targetmode=cogs SUPFAM SSF53098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098 UniProtKB INSD9_ECOLI http://www.uniprot.org/uniprot/INSD9_ECOLI UniProtKB-AC P0CF61 http://www.uniprot.org/uniprot/P0CF61 charge swissprot:INSD9_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSD9_ECOLI eggNOG ENOG4108MVM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MVM eggNOG ENOG410Z4Y8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Z4Y8 epestfind swissprot:INSD9_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSD9_ECOLI garnier swissprot:INSD9_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSD9_ECOLI helixturnhelix swissprot:INSD9_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSD9_ECOLI hmoment swissprot:INSD9_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSD9_ECOLI iep swissprot:INSD9_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSD9_ECOLI inforesidue swissprot:INSD9_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSD9_ECOLI octanol swissprot:INSD9_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSD9_ECOLI pepcoil swissprot:INSD9_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSD9_ECOLI pepdigest swissprot:INSD9_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSD9_ECOLI pepinfo swissprot:INSD9_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSD9_ECOLI pepnet swissprot:INSD9_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSD9_ECOLI pepstats swissprot:INSD9_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSD9_ECOLI pepwheel swissprot:INSD9_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSD9_ECOLI pepwindow swissprot:INSD9_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSD9_ECOLI sigcleave swissprot:INSD9_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSD9_ECOLI ## Database ID URL or Descriptions # AltName HIS6_ECOLI IGP synthase cyclase subunit # AltName HIS6_ECOLI IGP synthase subunit HisF # AltName HIS6_ECOLI ImGP synthase subunit HisF # BIOPHYSICOCHEMICAL PROPERTIES HIS6_ECOLI Kinetic parameters KM=240 uM for PRFAR {ECO 0000269|PubMed 8494895}; KM=23 uM for NH(4)Cl {ECO 0000269|PubMed 8494895}; pH dependence Optimum pH is 8-9. {ECO 0000269|PubMed 8494895}; # BRENDA 4.3.1.B2 2026 # BioGrid 4259164 5 # CATALYTIC ACTIVITY 5-[(5-phospho-1-deoxyribulos-1- ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4- carboxamide + L-glutamine = imidazole-glycerol phosphate + 5- aminoimidazol-4-carboxamide ribonucleotide + L-glutamate + H(2)O. {ECO:0000269|PubMed 8494895}. # CDD cd04731 HisF # EcoGene EG10448 hisF # FUNCTION HIS6_ECOLI IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0009382 imidazoleglycerol-phosphate synthase complex; IDA:EcoCyc. # GO_function GO:0000107 imidazoleglycerol-phosphate synthase activity; IDA:EcoCyc. # GO_function GO:0016829 lyase activity; IEA:UniProtKB-KW. # GO_process GO:0000105 histidine biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.20.20.70 -; 1. # HAMAP MF_01013 HisF # IntAct P60664 4 # InterPro IPR004651 HisF # InterPro IPR006062 His_biosynth # InterPro IPR011060 RibuloseP-bd_barrel # InterPro IPR013785 Aldolase_TIM # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00340 Histidine metabolism # Organism HIS6_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-histidine biosynthesis; L- histidine from 5-phospho-alpha-D-ribose 1-diphosphate step 5/9. # PATRIC 32119385 VBIEscCol129921_2102 # PIR JS0134 OYECHF # Pfam PF00977 His_biosynth # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HIS6_ECOLI Imidazole glycerol phosphate synthase subunit HisF # RefSeq NP_416529 NC_000913.3 # RefSeq WP_000880182 NZ_LN832404.1 # SIMILARITY Belongs to the HisA/HisF family. {ECO 0000305}. # SUBCELLULAR LOCATION HIS6_ECOLI Cytoplasm. # SUBUNIT Heterodimer of HisH and HisF. {ECO:0000269|PubMed 8494895}. # SUPFAM SSF51366 SSF51366 # TIGRFAMs TIGR00735 hisF # UniPathway UPA00031 UER00010 # eggNOG COG0107 LUCA # eggNOG ENOG4105C0S Bacteria BLAST swissprot:HIS6_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HIS6_ECOLI BioCyc ECOL316407:JW2007-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2007-MONOMER BioCyc EcoCyc:CYCLASE-MONOMER http://biocyc.org/getid?id=EcoCyc:CYCLASE-MONOMER BioCyc MetaCyc:CYCLASE-MONOMER http://biocyc.org/getid?id=MetaCyc:CYCLASE-MONOMER COG COG0107 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0107 DOI 10.1016/0022-2836(88)90194-5 http://dx.doi.org/10.1016/0022-2836(88)90194-5 DOI 10.1021/bi00070a029 http://dx.doi.org/10.1021/bi00070a029 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.3.989-996.2001 http://dx.doi.org/10.1128/JB.182.3.989-996.2001 EC_number EC:4.1.3.- http://www.genome.jp/dbget-bin/www_bget?EC:4.1.3.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D43637 http://www.ebi.ac.uk/ena/data/view/D43637 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X13462 http://www.ebi.ac.uk/ena/data/view/X13462 ENZYME 4.1.3.- http://enzyme.expasy.org/EC/4.1.3.- EchoBASE EB0443 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0443 EcoGene EG10448 http://www.ecogene.org/geneInfo.php?eg_id=EG10448 EnsemblBacteria AAC75086 http://www.ensemblgenomes.org/id/AAC75086 EnsemblBacteria AAC75086 http://www.ensemblgenomes.org/id/AAC75086 EnsemblBacteria BAA15857 http://www.ensemblgenomes.org/id/BAA15857 EnsemblBacteria BAA15857 http://www.ensemblgenomes.org/id/BAA15857 EnsemblBacteria BAA15857 http://www.ensemblgenomes.org/id/BAA15857 EnsemblBacteria b2025 http://www.ensemblgenomes.org/id/b2025 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0009382 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009382 GO_function GO:0000107 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000107 GO_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GO_process GO:0000105 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000105 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 946516 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946516 HAMAP MF_01013 http://hamap.expasy.org/unirule/MF_01013 HOGENOM HOG000224612 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000224612&db=HOGENOM6 InParanoid P60664 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P60664 IntAct P60664 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P60664* IntEnz 4.1.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.3 InterPro IPR004651 http://www.ebi.ac.uk/interpro/entry/IPR004651 InterPro IPR006062 http://www.ebi.ac.uk/interpro/entry/IPR006062 InterPro IPR011060 http://www.ebi.ac.uk/interpro/entry/IPR011060 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2007 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2007 KEGG_Gene eco:b2025 http://www.genome.jp/dbget-bin/www_bget?eco:b2025 KEGG_Orthology KO:K02500 http://www.genome.jp/dbget-bin/www_bget?KO:K02500 KEGG_Pathway ko00340 http://www.genome.jp/kegg-bin/show_pathway?ko00340 KEGG_Reaction rn:R04558 http://www.genome.jp/dbget-bin/www_bget?rn:R04558 OMA KGTNFVN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KGTNFVN PSORT swissprot:HIS6_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HIS6_ECOLI PSORT-B swissprot:HIS6_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HIS6_ECOLI PSORT2 swissprot:HIS6_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HIS6_ECOLI Pfam PF00977 http://pfam.xfam.org/family/PF00977 Phobius swissprot:HIS6_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HIS6_ECOLI PhylomeDB P60664 http://phylomedb.org/?seqid=P60664 ProteinModelPortal P60664 http://www.proteinmodelportal.org/query/uniprot/P60664 PubMed 11208798 http://www.ncbi.nlm.nih.gov/pubmed/11208798 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3062174 http://www.ncbi.nlm.nih.gov/pubmed/3062174 PubMed 7536735 http://www.ncbi.nlm.nih.gov/pubmed/7536735 PubMed 8494895 http://www.ncbi.nlm.nih.gov/pubmed/8494895 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416529 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416529 RefSeq WP_000880182 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000880182 SMR P60664 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P60664 STRING 511145.b2025 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2025&targetmode=cogs STRING COG0107 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0107&targetmode=cogs SUPFAM SSF51366 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51366 TIGRFAMs TIGR00735 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00735 UniProtKB HIS6_ECOLI http://www.uniprot.org/uniprot/HIS6_ECOLI UniProtKB-AC P60664 http://www.uniprot.org/uniprot/P60664 charge swissprot:HIS6_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HIS6_ECOLI eggNOG COG0107 http://eggnogapi.embl.de/nog_data/html/tree/COG0107 eggNOG ENOG4105C0S http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C0S epestfind swissprot:HIS6_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HIS6_ECOLI garnier swissprot:HIS6_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HIS6_ECOLI helixturnhelix swissprot:HIS6_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HIS6_ECOLI hmoment swissprot:HIS6_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HIS6_ECOLI iep swissprot:HIS6_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HIS6_ECOLI inforesidue swissprot:HIS6_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HIS6_ECOLI octanol swissprot:HIS6_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HIS6_ECOLI pepcoil swissprot:HIS6_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HIS6_ECOLI pepdigest swissprot:HIS6_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HIS6_ECOLI pepinfo swissprot:HIS6_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HIS6_ECOLI pepnet swissprot:HIS6_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HIS6_ECOLI pepstats swissprot:HIS6_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HIS6_ECOLI pepwheel swissprot:HIS6_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HIS6_ECOLI pepwindow swissprot:HIS6_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HIS6_ECOLI sigcleave swissprot:HIS6_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HIS6_ECOLI ## Database ID URL or Descriptions # AltName HTRE_ECOLI Heat shock protein E # BioGrid 4259738 125 # DISRUPTION PHENOTYPE Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain. {ECO:0000269|PubMed 20345943}. # EcoGene EG11972 htrE # FUNCTION HTRE_ECOLI Part of the yadCKLM-htrE-yadVN fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Probably involved in the export and assembly of fimbrial subunits across the outer membrane. {ECO 0000269|PubMed 20345943}. # GO_component GO:0009279 cell outer membrane; IBA:GO_Central. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015473 fimbrial usher porin activity; IBA:GO_Central. # GO_process GO:0009297 pilus assembly; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0022607 cellular component assembly # INDUCTION HTRE_ECOLI Repressed by H-NS. Induced by heat shock. {ECO 0000269|PubMed 20345943, ECO 0000269|PubMed 8102362}. # IntAct P33129 9 # InterPro IPR000015 Fimb_usher # InterPro IPR018030 Fimbrial_membr_usher_CS # InterPro IPR025885 PapC_N # InterPro IPR025949 PapC-like_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02000 Transporters # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko05133 Pertussis # MISCELLANEOUS The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed. {ECO:0000305|PubMed 20345943}. # Organism HTRE_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30451 PTHR30451 # PATRIC 32115385 VBIEscCol129921_0144 # PIR C64737 C64737 # PROSITE PS01151 FIMBRIAL_USHER # Pfam PF00577 Usher # Pfam PF13953 PapC_C # Pfam PF13954 PapC_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HTRE_ECOLI Outer membrane usher protein HtrE # RefSeq NP_414681 NC_000913.3 # RefSeq WP_000151605 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA23721.1; Type=Miscellaneous discrepancy; Note=Incorrect in position 61 onward due to a cloning artifact.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the fimbrial export usher family. {ECO 0000305}. # SUBCELLULAR LOCATION HTRE_ECOLI Cell outer membrane {ECO 0000250}; Multi- pass membrane protein {ECO 0000250}. # TCDB 1.B.11.3 the outer membrane fimbrial usher porin (fup) family # eggNOG COG3188 LUCA # eggNOG ENOG4105CW0 Bacteria BLAST swissprot:HTRE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HTRE_ECOLI BioCyc ECOL316407:JW0135-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0135-MONOMER BioCyc EcoCyc:EG11972-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11972-MONOMER COG COG3188 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3188 DIP DIP-9953N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9953N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1111/j.1462-2920.2010.02202.x http://dx.doi.org/10.1111/j.1462-2920.2010.02202.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L00680 http://www.ebi.ac.uk/ena/data/view/L00680 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1915 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1915 EcoGene EG11972 http://www.ecogene.org/geneInfo.php?eg_id=EG11972 EnsemblBacteria AAC73250 http://www.ensemblgenomes.org/id/AAC73250 EnsemblBacteria AAC73250 http://www.ensemblgenomes.org/id/AAC73250 EnsemblBacteria BAE76043 http://www.ensemblgenomes.org/id/BAE76043 EnsemblBacteria BAE76043 http://www.ensemblgenomes.org/id/BAE76043 EnsemblBacteria BAE76043 http://www.ensemblgenomes.org/id/BAE76043 EnsemblBacteria b0139 http://www.ensemblgenomes.org/id/b0139 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015473 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015473 GO_process GO:0009297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009297 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GeneID 944819 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944819 HOGENOM HOG000111416 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000111416&db=HOGENOM6 InParanoid P33129 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33129 IntAct P33129 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33129* InterPro IPR000015 http://www.ebi.ac.uk/interpro/entry/IPR000015 InterPro IPR018030 http://www.ebi.ac.uk/interpro/entry/IPR018030 InterPro IPR025885 http://www.ebi.ac.uk/interpro/entry/IPR025885 InterPro IPR025949 http://www.ebi.ac.uk/interpro/entry/IPR025949 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW0135 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0135 KEGG_Gene eco:b0139 http://www.genome.jp/dbget-bin/www_bget?eco:b0139 KEGG_Orthology KO:K07347 http://www.genome.jp/dbget-bin/www_bget?KO:K07347 KEGG_Pathway ko05133 http://www.genome.jp/kegg-bin/show_pathway?ko05133 MINT MINT-1300601 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1300601 OMA AYTTGET http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AYTTGET PANTHER PTHR30451 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30451 PROSITE PS01151 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01151 PSORT swissprot:HTRE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HTRE_ECOLI PSORT-B swissprot:HTRE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HTRE_ECOLI PSORT2 swissprot:HTRE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HTRE_ECOLI Pfam PF00577 http://pfam.xfam.org/family/PF00577 Pfam PF13953 http://pfam.xfam.org/family/PF13953 Pfam PF13954 http://pfam.xfam.org/family/PF13954 Phobius swissprot:HTRE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HTRE_ECOLI PhylomeDB P33129 http://phylomedb.org/?seqid=P33129 ProteinModelPortal P33129 http://www.proteinmodelportal.org/query/uniprot/P33129 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20345943 http://www.ncbi.nlm.nih.gov/pubmed/20345943 PubMed 8102362 http://www.ncbi.nlm.nih.gov/pubmed/8102362 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414681 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414681 RefSeq WP_000151605 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000151605 SMR P33129 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33129 STRING 511145.b0139 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0139&targetmode=cogs STRING COG3188 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3188&targetmode=cogs TCDB 1.B.11.3 http://www.tcdb.org/search/result.php?tc=1.B.11.3 UniProtKB HTRE_ECOLI http://www.uniprot.org/uniprot/HTRE_ECOLI UniProtKB-AC P33129 http://www.uniprot.org/uniprot/P33129 charge swissprot:HTRE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HTRE_ECOLI eggNOG COG3188 http://eggnogapi.embl.de/nog_data/html/tree/COG3188 eggNOG ENOG4105CW0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CW0 epestfind swissprot:HTRE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HTRE_ECOLI garnier swissprot:HTRE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HTRE_ECOLI helixturnhelix swissprot:HTRE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HTRE_ECOLI hmoment swissprot:HTRE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HTRE_ECOLI iep swissprot:HTRE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HTRE_ECOLI inforesidue swissprot:HTRE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HTRE_ECOLI octanol swissprot:HTRE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HTRE_ECOLI pepcoil swissprot:HTRE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HTRE_ECOLI pepdigest swissprot:HTRE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HTRE_ECOLI pepinfo swissprot:HTRE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HTRE_ECOLI pepnet swissprot:HTRE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HTRE_ECOLI pepstats swissprot:HTRE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HTRE_ECOLI pepwheel swissprot:HTRE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HTRE_ECOLI pepwindow swissprot:HTRE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HTRE_ECOLI sigcleave swissprot:HTRE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HTRE_ECOLI ## Database ID URL or Descriptions # BioGrid 4261154 12 # DEVELOPMENTAL STAGE OPGD_ECOLI Expressed essentially during the stationary growth phase when OPG synthesis has stopped. # EcoGene EG12859 mdoD # FUNCTION OPGD_ECOLI Probably involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans (OPGs). # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0003824 catalytic activity; IEA:InterPro. # GO_function GO:0030246 carbohydrate binding; IEA:InterPro. # GO_process GO:0009250 glucan biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0032951 regulation of beta-glucan biosynthetic process; IDA:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # Gene3D 2.60.40.10 -; 1. # Gene3D 2.70.98.10 -; 1. # HAMAP MF_01068 MdoD_OpgD # IntAct P40120 6 # InterPro IPR006311 TAT_signal # InterPro IPR007444 Glucan_biosyn_MdoG_C # InterPro IPR011013 Gal_mutarotase_SF_dom # InterPro IPR013783 Ig-like_fold # InterPro IPR014438 Glucan_biosyn_MdoGD # InterPro IPR014718 GH-type_carb-bd # InterPro IPR014756 Ig_E-set # InterPro IPR019546 TAT_signal_bac_arc # InterPro IPR023724 Glucan_biosyn_MdoD # Organism OPGD_ECOLI Escherichia coli (strain K12) # PATHWAY OPGD_ECOLI Glycan metabolism; osmoregulated periplasmic glucan (OPG) biosynthesis. # PATRIC 32118134 VBIEscCol129921_1487 # PIR C64894 C64894 # PIRSF PIRSF006281 MdoG # PROSITE PS51318 TAT # PTM OPGD_ECOLI Exported by the Tat system. The position of the signal peptide cleavage has been experimentally proven. Can also be exported by the Sec system. # Pfam PF04349 MdoG # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName OPGD_ECOLI Glucans biosynthesis protein D # RefSeq NP_415941 NC_000913.3 # RefSeq WP_000375961 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA15046.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the OpgD/OpgG family. {ECO 0000305}. # SUBCELLULAR LOCATION OPGD_ECOLI Periplasm. # SUPFAM SSF74650 SSF74650 # SUPFAM SSF81296 SSF81296 # TIGRFAMs TIGR01409 TAT_signal_seq # eggNOG COG3131 LUCA # eggNOG ENOG4105DJ9 Bacteria BLAST swissprot:OPGD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:OPGD_ECOLI BioCyc ECOL316407:JW1420-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1420-MONOMER BioCyc EcoCyc:EG12859-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12859-MONOMER DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1007/BF02464895 http://dx.doi.org/10.1007/BF02464895 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M610507200 http://dx.doi.org/10.1074/jbc.M610507200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.186.12.3695-3702.2004 http://dx.doi.org/10.1128/JB.186.12.3695-3702.2004 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X15860 http://www.ebi.ac.uk/ena/data/view/X15860 EchoBASE EB2701 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2701 EcoGene EG12859 http://www.ecogene.org/geneInfo.php?eg_id=EG12859 EnsemblBacteria AAC74506 http://www.ensemblgenomes.org/id/AAC74506 EnsemblBacteria AAC74506 http://www.ensemblgenomes.org/id/AAC74506 EnsemblBacteria BAA15046 http://www.ensemblgenomes.org/id/BAA15046 EnsemblBacteria BAA15046 http://www.ensemblgenomes.org/id/BAA15046 EnsemblBacteria BAA15046 http://www.ensemblgenomes.org/id/BAA15046 EnsemblBacteria b1424 http://www.ensemblgenomes.org/id/b1424 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0003824 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003824 GO_function GO:0030246 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030246 GO_process GO:0009250 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009250 GO_process GO:0032951 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032951 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 2.60.40.10 http://www.cathdb.info/version/latest/superfamily/2.60.40.10 Gene3D 2.70.98.10 http://www.cathdb.info/version/latest/superfamily/2.70.98.10 GeneID 945994 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945994 HAMAP MF_01068 http://hamap.expasy.org/unirule/MF_01068 HOGENOM HOG000288262 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000288262&db=HOGENOM6 InParanoid P40120 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P40120 IntAct P40120 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P40120* InterPro IPR006311 http://www.ebi.ac.uk/interpro/entry/IPR006311 InterPro IPR007444 http://www.ebi.ac.uk/interpro/entry/IPR007444 InterPro IPR011013 http://www.ebi.ac.uk/interpro/entry/IPR011013 InterPro IPR013783 http://www.ebi.ac.uk/interpro/entry/IPR013783 InterPro IPR014438 http://www.ebi.ac.uk/interpro/entry/IPR014438 InterPro IPR014718 http://www.ebi.ac.uk/interpro/entry/IPR014718 InterPro IPR014756 http://www.ebi.ac.uk/interpro/entry/IPR014756 InterPro IPR019546 http://www.ebi.ac.uk/interpro/entry/IPR019546 InterPro IPR023724 http://www.ebi.ac.uk/interpro/entry/IPR023724 KEGG_Gene ecj:JW1420 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1420 KEGG_Gene eco:b1424 http://www.genome.jp/dbget-bin/www_bget?eco:b1424 OMA FAGFRAF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FAGFRAF PROSITE PS51318 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51318 PSORT swissprot:OPGD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:OPGD_ECOLI PSORT-B swissprot:OPGD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:OPGD_ECOLI PSORT2 swissprot:OPGD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:OPGD_ECOLI Pfam PF04349 http://pfam.xfam.org/family/PF04349 Phobius swissprot:OPGD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:OPGD_ECOLI PhylomeDB P40120 http://phylomedb.org/?seqid=P40120 ProteinModelPortal P40120 http://www.proteinmodelportal.org/query/uniprot/P40120 PubMed 15175282 http://www.ncbi.nlm.nih.gov/pubmed/15175282 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17218314 http://www.ncbi.nlm.nih.gov/pubmed/17218314 PubMed 2671655 http://www.ncbi.nlm.nih.gov/pubmed/2671655 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_415941 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415941 RefSeq WP_000375961 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000375961 STRING 511145.b1424 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1424&targetmode=cogs SUPFAM SSF74650 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF74650 SUPFAM SSF81296 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81296 TIGRFAMs TIGR01409 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01409 UniProtKB OPGD_ECOLI http://www.uniprot.org/uniprot/OPGD_ECOLI UniProtKB-AC P40120 http://www.uniprot.org/uniprot/P40120 charge swissprot:OPGD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:OPGD_ECOLI eggNOG COG3131 http://eggnogapi.embl.de/nog_data/html/tree/COG3131 eggNOG ENOG4105DJ9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DJ9 epestfind swissprot:OPGD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:OPGD_ECOLI garnier swissprot:OPGD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:OPGD_ECOLI helixturnhelix swissprot:OPGD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:OPGD_ECOLI hmoment swissprot:OPGD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:OPGD_ECOLI iep swissprot:OPGD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:OPGD_ECOLI inforesidue swissprot:OPGD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:OPGD_ECOLI octanol swissprot:OPGD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:OPGD_ECOLI pepcoil swissprot:OPGD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:OPGD_ECOLI pepdigest swissprot:OPGD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:OPGD_ECOLI pepinfo swissprot:OPGD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:OPGD_ECOLI pepnet swissprot:OPGD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:OPGD_ECOLI pepstats swissprot:OPGD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:OPGD_ECOLI pepwheel swissprot:OPGD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:OPGD_ECOLI pepwindow swissprot:OPGD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:OPGD_ECOLI sigcleave swissprot:OPGD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:OPGD_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES SAD_ECOLI Kinetic parameters KM=13.3 uM for succinate semialdehyde (with 0.6 mM NAD, at pH 8 and at 30 degrees Celsius) {ECO 0000269|PubMed 7011797}; KM=33.7 uM for succinate semialdehyde (with 0.1 mM NAD, at pH 8 and at 30 degrees Celsius) {ECO 0000269|PubMed 7011797}; Note=The enzyme reduced NADP at 15 % of the rate of NAD reduction.; pH dependence Optimum pH is 8.2. Activity decreases sharply as the pH is raised above pH 9.2. {ECO 0000269|PubMed 7011797}; # BioGrid 4261693 9 # CATALYTIC ACTIVITY Succinate semialdehyde + NAD(P)(+) + H(2)O = succinate + NAD(P)H. {ECO:0000269|PubMed 17873044}. # DISRUPTION PHENOTYPE Cells are unable to grow on 4- hydroxyphenylacetate. {ECO:0000269|PubMed 6756331}. # EcoGene EG13817 yneI # FUNCTION SAD_ECOLI Catalyzes the NAD(+)-dependent oxidation of succinate semialdehyde to succinate. It acts preferentially with NAD as cosubstrate but can also use NADP. Prevents the toxic accumulation of succinate semialdehyde (SSA) and plays an important role when arginine and putrescine are used as the sole nitrogen or carbon sources. {ECO 0000269|PubMed 17873044, ECO 0000269|PubMed 20639325, ECO 0000269|PubMed 7009588, ECO 0000269|PubMed 7011797}. # GO_function GO:0004029 aldehyde dehydrogenase (NAD) activity; IBA:GO_Central. # GO_function GO:0004777 succinate-semialdehyde dehydrogenase (NAD+) activity; IDA:UniProtKB. # GO_function GO:0009013 succinate-semialdehyde dehydrogenase [NAD(P)+] activity; IDA:EcoliWiki. # GO_process GO:0006527 arginine catabolic process; IMP:EcoCyc. # GO_process GO:0006807 nitrogen compound metabolic process; IDA:UniProtKB. # GO_process GO:0009447 putrescine catabolic process; IMP:EcoCyc. # GO_process GO:0009450 gamma-aminobutyric acid catabolic process; IMP:EcoliWiki. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.309.10 -; 1. # Gene3D 3.40.605.10 -; 1. # INDUCTION SAD_ECOLI By p-hydroxyphenylacetate, succinate semialdehyde (SSA) and putrescine. Highly expressed under several stress conditions together with many genes related to the metabolism of nitrogen compounds. {ECO 0000269|PubMed 17873044, ECO 0000269|PubMed 20639325}. # InterPro IPR015590 Aldehyde_DH_dom # InterPro IPR016160 Ald_DH_CS_CYS # InterPro IPR016161 Ald_DH/histidinol_DH # InterPro IPR016162 Ald_DH_N # InterPro IPR016163 Ald_DH_C # KEGG_Brite ko01000 Enzymes # Organism SAD_ECOLI Escherichia coli (strain K12) # PATHWAY SAD_ECOLI Amino-acid degradation; 4-aminobutanoate degradation. # PATRIC 32118348 VBIEscCol129921_1594 # PIR H64906 H64906 # PROSITE PS00070 ALDEHYDE_DEHYDR_CYS # Pfam PF00171 Aldedh # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SAD_ECOLI Succinate semialdehyde dehydrogenase [NAD(P)+] Sad # RefSeq NP_416042 NC_000913.3 # RefSeq WP_000156615 NZ_LN832404.1 # SIMILARITY Belongs to the aldehyde dehydrogenase family. {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 7011797}. # SUPFAM SSF53720 SSF53720 # eggNOG COG1012 LUCA # eggNOG ENOG4105C26 Bacteria BLAST swissprot:SAD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SAD_ECOLI BioCyc ECOL316407:JW5247-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5247-MONOMER BioCyc EcoCyc:G6811-MONOMER http://biocyc.org/getid?id=EcoCyc:G6811-MONOMER BioCyc MetaCyc:G6811-MONOMER http://biocyc.org/getid?id=MetaCyc:G6811-MONOMER COG COG1012 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1012 DIP DIP-12758N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12758N DOI 10.1007/BF00407964 http://dx.doi.org/10.1007/BF00407964 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1111/j.1432-1033.1981.tb05098.x http://dx.doi.org/10.1111/j.1432-1033.1981.tb05098.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00308-10 http://dx.doi.org/10.1128/JB.00308-10 DOI 10.1128/JB.01027-07 http://dx.doi.org/10.1128/JB.01027-07 EC_number EC:1.2.1.16 http://www.genome.jp/dbget-bin/www_bget?EC:1.2.1.16 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.2.1.16 http://enzyme.expasy.org/EC/1.2.1.16 EchoBASE EB3578 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3578 EcoGene EG13817 http://www.ecogene.org/geneInfo.php?eg_id=EG13817 EnsemblBacteria AAC74598 http://www.ensemblgenomes.org/id/AAC74598 EnsemblBacteria AAC74598 http://www.ensemblgenomes.org/id/AAC74598 EnsemblBacteria BAA15208 http://www.ensemblgenomes.org/id/BAA15208 EnsemblBacteria BAA15208 http://www.ensemblgenomes.org/id/BAA15208 EnsemblBacteria BAA15208 http://www.ensemblgenomes.org/id/BAA15208 EnsemblBacteria b1525 http://www.ensemblgenomes.org/id/b1525 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004029 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004029 GO_function GO:0004777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004777 GO_function GO:0009013 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009013 GO_process GO:0006527 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006527 GO_process GO:0006807 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006807 GO_process GO:0009447 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009447 GO_process GO:0009450 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009450 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.309.10 http://www.cathdb.info/version/latest/superfamily/3.40.309.10 Gene3D 3.40.605.10 http://www.cathdb.info/version/latest/superfamily/3.40.605.10 GeneID 947440 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947440 HOGENOM HOG000271513 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000271513&db=HOGENOM6 InParanoid P76149 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76149 IntAct P76149 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76149* IntEnz 1.2.1.16 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.2.1.16 InterPro IPR015590 http://www.ebi.ac.uk/interpro/entry/IPR015590 InterPro IPR016160 http://www.ebi.ac.uk/interpro/entry/IPR016160 InterPro IPR016161 http://www.ebi.ac.uk/interpro/entry/IPR016161 InterPro IPR016162 http://www.ebi.ac.uk/interpro/entry/IPR016162 InterPro IPR016163 http://www.ebi.ac.uk/interpro/entry/IPR016163 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5247 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5247 KEGG_Gene eco:b1525 http://www.genome.jp/dbget-bin/www_bget?eco:b1525 KEGG_Orthology KO:K08324 http://www.genome.jp/dbget-bin/www_bget?KO:K08324 OMA NIFAGHD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NIFAGHD PROSITE PS00070 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00070 PSORT swissprot:SAD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SAD_ECOLI PSORT-B swissprot:SAD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SAD_ECOLI PSORT2 swissprot:SAD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SAD_ECOLI Pfam PF00171 http://pfam.xfam.org/family/PF00171 Phobius swissprot:SAD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SAD_ECOLI PhylomeDB P76149 http://phylomedb.org/?seqid=P76149 ProteinModelPortal P76149 http://www.proteinmodelportal.org/query/uniprot/P76149 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17873044 http://www.ncbi.nlm.nih.gov/pubmed/17873044 PubMed 20639325 http://www.ncbi.nlm.nih.gov/pubmed/20639325 PubMed 6756331 http://www.ncbi.nlm.nih.gov/pubmed/6756331 PubMed 7009588 http://www.ncbi.nlm.nih.gov/pubmed/7009588 PubMed 7011797 http://www.ncbi.nlm.nih.gov/pubmed/7011797 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416042 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416042 RefSeq WP_000156615 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000156615 SMR P76149 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76149 STRING 511145.b1525 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1525&targetmode=cogs STRING COG1012 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1012&targetmode=cogs SUPFAM SSF53720 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53720 SWISS-2DPAGE P76149 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P76149 UniProtKB SAD_ECOLI http://www.uniprot.org/uniprot/SAD_ECOLI UniProtKB-AC P76149 http://www.uniprot.org/uniprot/P76149 charge swissprot:SAD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SAD_ECOLI eggNOG COG1012 http://eggnogapi.embl.de/nog_data/html/tree/COG1012 eggNOG ENOG4105C26 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C26 epestfind swissprot:SAD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SAD_ECOLI garnier swissprot:SAD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SAD_ECOLI helixturnhelix swissprot:SAD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SAD_ECOLI hmoment swissprot:SAD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SAD_ECOLI iep swissprot:SAD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SAD_ECOLI inforesidue swissprot:SAD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SAD_ECOLI octanol swissprot:SAD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SAD_ECOLI pepcoil swissprot:SAD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SAD_ECOLI pepdigest swissprot:SAD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SAD_ECOLI pepinfo swissprot:SAD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SAD_ECOLI pepnet swissprot:SAD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SAD_ECOLI pepstats swissprot:SAD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SAD_ECOLI pepwheel swissprot:SAD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SAD_ECOLI pepwindow swissprot:SAD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SAD_ECOLI sigcleave swissprot:SAD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SAD_ECOLI ## Database ID URL or Descriptions # BioGrid 4261651 11 # CDD cd06261 TM_PBP2 # DISRUPTION PHENOTYPE The yecS-ydjN double mutant is completely resistant to both L-selenaproline and L-selenocystine. {ECO:0000269|PubMed 25139244}. # ENZYME REGULATION The FliY-YecC-YecS system is inhibited by L- cystine, L-cysteine, DL-2,6-diaminopimelic acid and L- cystathionine, and is stimulated by D-cysteine. {ECO:0000269|PubMed 25139244}. # EcoGene EG14037 yecS # FUNCTION YECS_ECOLI Part of the ABC transporter complex FliY-YecC-YecS involved in L-cystine transport. The system can probably also transport L-cysteine, and it mediates accumulation of the toxic compounds L-selenaproline (SCA) and L-selenocystine (SeCys) (PubMed 25139244). Probably responsible for the translocation of the substrate across the membrane (Probable). {ECO 0000269|PubMed 25139244, ECO 0000305}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015184 L-cystine transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0033229 cysteine transmembrane transporter activity; IDA:EcoCyc. # GO_process GO:0015811 L-cystine transport; IDA:EcoCyc. # GO_process GO:0042883 cysteine transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # Gene3D 1.10.3720.10 -; 1. # InterPro IPR000515 MetI-like # InterPro IPR010065 AA_ABC_transptr_permease_3TM # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00234 Cystine transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism YECS_ECOLI Escherichia coli (strain K12) # PATRIC 32119171 VBIEscCol129921_2000 # PIR C64955 C64955 # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName L-cystine transport system permease protein YecS {ECO 0000305} # RefSeq NP_416428 NC_000913.3 # RefSeq WP_001158220 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION YECS_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255}. # SUBUNIT The complex is composed of two ATP-binding proteins (YecC), two transmembrane proteins (YecS) and a solute-binding protein (FliY). {ECO 0000305}. # SUPFAM SSF161098 SSF161098 # TCDB 3.A.1.3.10 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR01726 HEQRo_perm_3TM # eggNOG COG0765 LUCA # eggNOG ENOG4105E5Q Bacteria BLAST swissprot:YECS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YECS_ECOLI BioCyc ECOL316407:JW1903-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1903-MONOMER BioCyc EcoCyc:G7037-MONOMER http://biocyc.org/getid?id=EcoCyc:G7037-MONOMER BioCyc MetaCyc:G7037-MONOMER http://biocyc.org/getid?id=MetaCyc:G7037-MONOMER COG COG0765 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0765 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1111/jam.12623 http://dx.doi.org/10.1111/jam.12623 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3791 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3791 EcoGene EG14037 http://www.ecogene.org/geneInfo.php?eg_id=EG14037 EnsemblBacteria AAC74985 http://www.ensemblgenomes.org/id/AAC74985 EnsemblBacteria AAC74985 http://www.ensemblgenomes.org/id/AAC74985 EnsemblBacteria BAA15738 http://www.ensemblgenomes.org/id/BAA15738 EnsemblBacteria BAA15738 http://www.ensemblgenomes.org/id/BAA15738 EnsemblBacteria BAA15738 http://www.ensemblgenomes.org/id/BAA15738 EnsemblBacteria b1918 http://www.ensemblgenomes.org/id/b1918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015184 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015184 GO_function GO:0033229 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033229 GO_process GO:0015811 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015811 GO_process GO:0042883 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042883 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 949105 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949105 HOGENOM HOG000267552 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267552&db=HOGENOM6 InParanoid P0AFT2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFT2 IntAct P0AFT2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFT2* InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 InterPro IPR010065 http://www.ebi.ac.uk/interpro/entry/IPR010065 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1903 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1903 KEGG_Gene eco:b1918 http://www.genome.jp/dbget-bin/www_bget?eco:b1918 KEGG_Orthology KO:K10009 http://www.genome.jp/dbget-bin/www_bget?KO:K10009 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA VNWIARI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VNWIARI PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:YECS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YECS_ECOLI PSORT-B swissprot:YECS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YECS_ECOLI PSORT2 swissprot:YECS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YECS_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Phobius swissprot:YECS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YECS_ECOLI PhylomeDB P0AFT2 http://phylomedb.org/?seqid=P0AFT2 ProteinModelPortal P0AFT2 http://www.proteinmodelportal.org/query/uniprot/P0AFT2 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 25139244 http://www.ncbi.nlm.nih.gov/pubmed/25139244 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416428 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416428 RefSeq WP_001158220 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001158220 SMR P0AFT2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFT2 STRING 511145.b1918 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1918&targetmode=cogs STRING COG0765 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0765&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.3.10 http://www.tcdb.org/search/result.php?tc=3.A.1.3.10 TIGRFAMs TIGR01726 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01726 UniProtKB YECS_ECOLI http://www.uniprot.org/uniprot/YECS_ECOLI UniProtKB-AC P0AFT2 http://www.uniprot.org/uniprot/P0AFT2 charge swissprot:YECS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YECS_ECOLI eggNOG COG0765 http://eggnogapi.embl.de/nog_data/html/tree/COG0765 eggNOG ENOG4105E5Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E5Q epestfind swissprot:YECS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YECS_ECOLI garnier swissprot:YECS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YECS_ECOLI helixturnhelix swissprot:YECS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YECS_ECOLI hmoment swissprot:YECS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YECS_ECOLI iep swissprot:YECS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YECS_ECOLI inforesidue swissprot:YECS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YECS_ECOLI octanol swissprot:YECS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YECS_ECOLI pepcoil swissprot:YECS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YECS_ECOLI pepdigest swissprot:YECS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YECS_ECOLI pepinfo swissprot:YECS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YECS_ECOLI pepnet swissprot:YECS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YECS_ECOLI pepstats swissprot:YECS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YECS_ECOLI pepwheel swissprot:YECS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YECS_ECOLI pepwindow swissprot:YECS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YECS_ECOLI sigcleave swissprot:YECS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YECS_ECOLI ## Database ID URL or Descriptions # BRENDA 3.1.2 2026 # BioGrid 4262710 8 # ESTHER ecoli-yjfp 5_AlphaBeta_hydrolase # EcoGene EG12490 yjfP # FUNCTION YJFP_ECOLI Displays esterase activity toward palmitoyl-CoA and pNP- butyrate. {ECO 0000269|PubMed 15808744}. # GO_function GO:0008236 serine-type peptidase activity; IEA:InterPro. # GO_function GO:0016787 hydrolase activity; IDA:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008233 peptidase activity # Gene3D 3.40.50.1820 -; 1. # InterPro IPR001375 Peptidase_S9 # InterPro IPR029058 AB_hydrolase # Organism YJFP_ECOLI Escherichia coli (strain K12) # PATRIC 32123955 VBIEscCol129921_4322 # PIR S56415 S56415 # Pfam PF00326 Peptidase_S9 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJFP_ECOLI Esterase YjfP # RefSeq NP_418611 NC_000913.3 # RefSeq WP_000569707 NZ_LN832404.1 # SUPFAM SSF53474 SSF53474 # eggNOG COG1073 LUCA # eggNOG ENOG4108MXZ Bacteria BLAST swissprot:YJFP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJFP_ECOLI BioCyc ECOL316407:JW4148-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4148-MONOMER BioCyc EcoCyc:G7853-MONOMER http://biocyc.org/getid?id=EcoCyc:G7853-MONOMER BioCyc MetaCyc:G7853-MONOMER http://biocyc.org/getid?id=MetaCyc:G7853-MONOMER COG COG1073 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1073 DOI 10.1016/j.fmrre.2004.12.006 http://dx.doi.org/10.1016/j.fmrre.2004.12.006 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 3.1.-.- http://enzyme.expasy.org/EC/3.1.-.- EchoBASE EB2383 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2383 EcoGene EG12490 http://www.ecogene.org/geneInfo.php?eg_id=EG12490 EnsemblBacteria AAC77147 http://www.ensemblgenomes.org/id/AAC77147 EnsemblBacteria AAC77147 http://www.ensemblgenomes.org/id/AAC77147 EnsemblBacteria BAE78191 http://www.ensemblgenomes.org/id/BAE78191 EnsemblBacteria BAE78191 http://www.ensemblgenomes.org/id/BAE78191 EnsemblBacteria BAE78191 http://www.ensemblgenomes.org/id/BAE78191 EnsemblBacteria b4190 http://www.ensemblgenomes.org/id/b4190 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008236 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008236 GO_function GO:0016787 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016787 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 Gene3D 3.40.50.1820 http://www.cathdb.info/version/latest/superfamily/3.40.50.1820 GeneID 948707 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948707 HOGENOM HOG000063642 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000063642&db=HOGENOM6 InParanoid P39298 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39298 IntAct P39298 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39298* IntEnz 3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1 InterPro IPR001375 http://www.ebi.ac.uk/interpro/entry/IPR001375 InterPro IPR029058 http://www.ebi.ac.uk/interpro/entry/IPR029058 KEGG_Gene ecj:JW4148 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4148 KEGG_Gene eco:b4190 http://www.genome.jp/dbget-bin/www_bget?eco:b4190 KEGG_Orthology KO:K06889 http://www.genome.jp/dbget-bin/www_bget?KO:K06889 OMA PLFIWHG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PLFIWHG PSORT swissprot:YJFP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJFP_ECOLI PSORT-B swissprot:YJFP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJFP_ECOLI PSORT2 swissprot:YJFP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJFP_ECOLI Pfam PF00326 http://pfam.xfam.org/family/PF00326 Phobius swissprot:YJFP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJFP_ECOLI PhylomeDB P39298 http://phylomedb.org/?seqid=P39298 ProteinModelPortal P39298 http://www.proteinmodelportal.org/query/uniprot/P39298 PubMed 15808744 http://www.ncbi.nlm.nih.gov/pubmed/15808744 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418611 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418611 RefSeq WP_000569707 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000569707 SMR P39298 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39298 STRING 511145.b4190 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4190&targetmode=cogs STRING COG1073 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1073&targetmode=cogs SUPFAM SSF53474 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53474 UniProtKB YJFP_ECOLI http://www.uniprot.org/uniprot/YJFP_ECOLI UniProtKB-AC P39298 http://www.uniprot.org/uniprot/P39298 charge swissprot:YJFP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJFP_ECOLI eggNOG COG1073 http://eggnogapi.embl.de/nog_data/html/tree/COG1073 eggNOG ENOG4108MXZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MXZ epestfind swissprot:YJFP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJFP_ECOLI garnier swissprot:YJFP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJFP_ECOLI helixturnhelix swissprot:YJFP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJFP_ECOLI hmoment swissprot:YJFP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJFP_ECOLI iep swissprot:YJFP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJFP_ECOLI inforesidue swissprot:YJFP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJFP_ECOLI octanol swissprot:YJFP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJFP_ECOLI pepcoil swissprot:YJFP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJFP_ECOLI pepdigest swissprot:YJFP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJFP_ECOLI pepinfo swissprot:YJFP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJFP_ECOLI pepnet swissprot:YJFP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJFP_ECOLI pepstats swissprot:YJFP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJFP_ECOLI pepwheel swissprot:YJFP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJFP_ECOLI pepwindow swissprot:YJFP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJFP_ECOLI sigcleave swissprot:YJFP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJFP_ECOLI ## Database ID URL or Descriptions # AltName HPPK_ECOLI 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase # AltName HPPK_ECOLI 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase # BRENDA 2.7.6 2026 # CATALYTIC ACTIVITY HPPK_ECOLI ATP + 6-hydroxymethyl-7,8-dihydropterin = AMP + 6-hydroxymethyl-7,8-dihydropterin diphosphate. # CDD cd00483 HPPK # EcoGene EG11374 folK # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0003848 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity; IDA:EcoliWiki. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016301 kinase activity; IEA:UniProtKB-KW. # GO_process GO:0046654 tetrahydrofolate biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0046656 folic acid biosynthetic process; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.30.70.560 -; 1. # IntAct P26281 2 # InterPro IPR000550 Hppk # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00790 Folate biosynthesis # MISCELLANEOUS HPPK_ECOLI This enzyme is heat stable. # Organism HPPK_ECOLI Escherichia coli (strain K12) # PATHWAY Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2- amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate step 4/4. # PATRIC 32115391 VBIEscCol129921_0147 # PDB 1DY3 X-ray; 2.00 A; A=2-159 # PDB 1EQ0 NMR; -; A=2-159 # PDB 1EQM X-ray; 1.50 A; A=2-159 # PDB 1EX8 X-ray; 1.85 A; A=2-159 # PDB 1F9H X-ray; 1.50 A; A=2-159 # PDB 1G4C X-ray; 1.65 A; A/B=2-159 # PDB 1HKA X-ray; 1.50 A; A=2-159 # PDB 1HQ2 X-ray; 1.25 A; A=2-159 # PDB 1IM6 X-ray; 1.74 A; A=2-159 # PDB 1KBR X-ray; 1.55 A; A=2-159 # PDB 1Q0N X-ray; 1.25 A; A=2-159 # PDB 1RAO X-ray; 1.56 A; A=2-159 # PDB 1RB0 X-ray; 1.35 A; A=2-159 # PDB 1RTZ X-ray; 1.33 A; A=2-159 # PDB 1RU1 X-ray; 1.40 A; A/B=2-159 # PDB 1RU2 X-ray; 1.48 A; A=2-159 # PDB 1TMJ X-ray; 1.45 A; A=2-159 # PDB 1TMM X-ray; 1.25 A; A/B=2-159 # PDB 2F63 NMR; -; A=2-159 # PDB 2F65 NMR; -; A=2-159 # PDB 3HCX X-ray; 1.75 A; A=2-159 # PDB 3HD1 X-ray; 1.30 A; A=2-159 # PDB 3HD2 X-ray; 1.10 A; A=2-159 # PDB 3HSD X-ray; 1.65 A; A/B=2-159 # PDB 3HSG X-ray; 1.14 A; A=2-159 # PDB 3HSJ X-ray; 1.18 A; A=2-159 # PDB 3HSZ X-ray; 1.40 A; A=2-159 # PDB 3HT0 X-ray; 1.40 A; A=2-159 # PDB 3ILI X-ray; 1.45 A; A=2-159 # PDB 3ILJ X-ray; 1.65 A; A=2-159 # PDB 3ILL X-ray; 1.73 A; A=2-159 # PDB 3ILO X-ray; 1.10 A; A=2-159 # PDB 3IP0 X-ray; 0.89 A; A=2-159 # PDB 3KUE X-ray; 1.54 A; A=2-159 # PDB 3KUG X-ray; 2.00 A; A=2-159 # PDB 3KUH X-ray; 1.35 A; A=2-159 # PDB 3UD5 X-ray; 2.00 A; A=2-159 # PDB 3UDE X-ray; 1.88 A; A=2-159 # PDB 3UDV X-ray; 1.88 A; A=2-159 # PDB 4F7V X-ray; 1.73 A; A=2-159 # PDB 4M5G X-ray; 1.31 A; A=1-159 # PDB 4M5H X-ray; 1.11 A; A=1-159 # PDB 4M5I X-ray; 1.08 A; A=1-159 # PDB 4M5J X-ray; 1.70 A; A=1-159 # PDB 4M5K X-ray; 1.30 A; A=1-159 # PDB 4M5L X-ray; 1.09 A; A=1-159 # PDB 4M5M X-ray; 1.12 A; A=1-159 # PDB 4M5N X-ray; 2.00 A; A/B=1-159 # PDB 5ETK X-ray; 1.09 A; A=1-159 # PDB 5ETL X-ray; 1.82 A; A/B/C/D=1-159 # PDB 5ETM X-ray; 1.46 A; A=1-159 # PDB 5ETN X-ray; 1.40 A; A=1-159 # PDB 5ETO X-ray; 1.07 A; A=1-159 # PDB 5ETP X-ray; 1.05 A; A=1-159 # PIR A43325 A43325 # PROSITE PS00794 HPPK # Pfam PF01288 HPPK # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HPPK_ECOLI 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase # RefSeq NP_414684 NC_000913.3 # RefSeq WP_000215139 NZ_LN832404.1 # SIMILARITY Belongs to the HPPK family. {ECO 0000305}. # SUBUNIT HPPK_ECOLI Monomer. # SUPFAM SSF55083 SSF55083 # TIGRFAMs TIGR01498 folK # UniPathway UPA00077 UER00155 # eggNOG COG0801 LUCA # eggNOG ENOG4105K8U Bacteria BLAST swissprot:HPPK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HPPK_ECOLI BioCyc ECOL316407:JW0138-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0138-MONOMER BioCyc EcoCyc:H2PTERIDINEPYROPHOSPHOKIN-MONOMER http://biocyc.org/getid?id=EcoCyc:H2PTERIDINEPYROPHOSPHOKIN-MONOMER BioCyc MetaCyc:H2PTERIDINEPYROPHOSPHOKIN-MONOMER http://biocyc.org/getid?id=MetaCyc:H2PTERIDINEPYROPHOSPHOKIN-MONOMER COG COG0801 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0801 DOI 10.1016/S0014-5793(99)00860-1 http://dx.doi.org/10.1016/S0014-5793(99)00860-1 DOI 10.1016/S0969-2126(99)80065-3 http://dx.doi.org/10.1016/S0969-2126(99)80065-3 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.6.3 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.6.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L06495 http://www.ebi.ac.uk/ena/data/view/L06495 EMBL M20574 http://www.ebi.ac.uk/ena/data/view/M20574 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.6.3 http://enzyme.expasy.org/EC/2.7.6.3 EchoBASE EB1348 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1348 EcoGene EG11374 http://www.ecogene.org/geneInfo.php?eg_id=EG11374 EnsemblBacteria AAC73253 http://www.ensemblgenomes.org/id/AAC73253 EnsemblBacteria AAC73253 http://www.ensemblgenomes.org/id/AAC73253 EnsemblBacteria BAB96719 http://www.ensemblgenomes.org/id/BAB96719 EnsemblBacteria BAB96719 http://www.ensemblgenomes.org/id/BAB96719 EnsemblBacteria BAB96719 http://www.ensemblgenomes.org/id/BAB96719 EnsemblBacteria b0142 http://www.ensemblgenomes.org/id/b0142 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0003848 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003848 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_process GO:0046654 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046654 GO_process GO:0046656 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046656 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.30.70.560 http://www.cathdb.info/version/latest/superfamily/3.30.70.560 GeneID 948792 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948792 HOGENOM HOG000217741 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000217741&db=HOGENOM6 InParanoid P26281 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P26281 IntAct P26281 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P26281* IntEnz 2.7.6.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.6.3 InterPro IPR000550 http://www.ebi.ac.uk/interpro/entry/IPR000550 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0138 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0138 KEGG_Gene eco:b0142 http://www.genome.jp/dbget-bin/www_bget?eco:b0142 KEGG_Orthology KO:K00950 http://www.genome.jp/dbget-bin/www_bget?KO:K00950 KEGG_Pathway ko00790 http://www.genome.jp/kegg-bin/show_pathway?ko00790 KEGG_Reaction rn:R03503 http://www.genome.jp/dbget-bin/www_bget?rn:R03503 OMA DWFLNAA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DWFLNAA PDB 1DY3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1DY3 PDB 1EQ0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1EQ0 PDB 1EQM http://www.ebi.ac.uk/pdbe-srv/view/entry/1EQM PDB 1EX8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1EX8 PDB 1F9H http://www.ebi.ac.uk/pdbe-srv/view/entry/1F9H PDB 1G4C http://www.ebi.ac.uk/pdbe-srv/view/entry/1G4C PDB 1HKA http://www.ebi.ac.uk/pdbe-srv/view/entry/1HKA PDB 1HQ2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1HQ2 PDB 1IM6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1IM6 PDB 1KBR http://www.ebi.ac.uk/pdbe-srv/view/entry/1KBR PDB 1Q0N http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q0N PDB 1RAO http://www.ebi.ac.uk/pdbe-srv/view/entry/1RAO PDB 1RB0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1RB0 PDB 1RTZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1RTZ PDB 1RU1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1RU1 PDB 1RU2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1RU2 PDB 1TMJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1TMJ PDB 1TMM http://www.ebi.ac.uk/pdbe-srv/view/entry/1TMM PDB 2F63 http://www.ebi.ac.uk/pdbe-srv/view/entry/2F63 PDB 2F65 http://www.ebi.ac.uk/pdbe-srv/view/entry/2F65 PDB 3HCX http://www.ebi.ac.uk/pdbe-srv/view/entry/3HCX PDB 3HD1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3HD1 PDB 3HD2 http://www.ebi.ac.uk/pdbe-srv/view/entry/3HD2 PDB 3HSD http://www.ebi.ac.uk/pdbe-srv/view/entry/3HSD PDB 3HSG http://www.ebi.ac.uk/pdbe-srv/view/entry/3HSG PDB 3HSJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3HSJ PDB 3HSZ http://www.ebi.ac.uk/pdbe-srv/view/entry/3HSZ PDB 3HT0 http://www.ebi.ac.uk/pdbe-srv/view/entry/3HT0 PDB 3ILI http://www.ebi.ac.uk/pdbe-srv/view/entry/3ILI PDB 3ILJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3ILJ PDB 3ILL http://www.ebi.ac.uk/pdbe-srv/view/entry/3ILL PDB 3ILO http://www.ebi.ac.uk/pdbe-srv/view/entry/3ILO PDB 3IP0 http://www.ebi.ac.uk/pdbe-srv/view/entry/3IP0 PDB 3KUE http://www.ebi.ac.uk/pdbe-srv/view/entry/3KUE PDB 3KUG http://www.ebi.ac.uk/pdbe-srv/view/entry/3KUG PDB 3KUH http://www.ebi.ac.uk/pdbe-srv/view/entry/3KUH PDB 3UD5 http://www.ebi.ac.uk/pdbe-srv/view/entry/3UD5 PDB 3UDE http://www.ebi.ac.uk/pdbe-srv/view/entry/3UDE PDB 3UDV http://www.ebi.ac.uk/pdbe-srv/view/entry/3UDV PDB 4F7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4F7V PDB 4M5G http://www.ebi.ac.uk/pdbe-srv/view/entry/4M5G PDB 4M5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4M5H PDB 4M5I http://www.ebi.ac.uk/pdbe-srv/view/entry/4M5I PDB 4M5J http://www.ebi.ac.uk/pdbe-srv/view/entry/4M5J PDB 4M5K http://www.ebi.ac.uk/pdbe-srv/view/entry/4M5K PDB 4M5L http://www.ebi.ac.uk/pdbe-srv/view/entry/4M5L PDB 4M5M http://www.ebi.ac.uk/pdbe-srv/view/entry/4M5M PDB 4M5N http://www.ebi.ac.uk/pdbe-srv/view/entry/4M5N PDB 5ETK http://www.ebi.ac.uk/pdbe-srv/view/entry/5ETK PDB 5ETL http://www.ebi.ac.uk/pdbe-srv/view/entry/5ETL PDB 5ETM http://www.ebi.ac.uk/pdbe-srv/view/entry/5ETM PDB 5ETN http://www.ebi.ac.uk/pdbe-srv/view/entry/5ETN PDB 5ETO http://www.ebi.ac.uk/pdbe-srv/view/entry/5ETO PDB 5ETP http://www.ebi.ac.uk/pdbe-srv/view/entry/5ETP PDBsum 1DY3 http://www.ebi.ac.uk/pdbsum/1DY3 PDBsum 1EQ0 http://www.ebi.ac.uk/pdbsum/1EQ0 PDBsum 1EQM http://www.ebi.ac.uk/pdbsum/1EQM PDBsum 1EX8 http://www.ebi.ac.uk/pdbsum/1EX8 PDBsum 1F9H http://www.ebi.ac.uk/pdbsum/1F9H PDBsum 1G4C http://www.ebi.ac.uk/pdbsum/1G4C PDBsum 1HKA http://www.ebi.ac.uk/pdbsum/1HKA PDBsum 1HQ2 http://www.ebi.ac.uk/pdbsum/1HQ2 PDBsum 1IM6 http://www.ebi.ac.uk/pdbsum/1IM6 PDBsum 1KBR http://www.ebi.ac.uk/pdbsum/1KBR PDBsum 1Q0N http://www.ebi.ac.uk/pdbsum/1Q0N PDBsum 1RAO http://www.ebi.ac.uk/pdbsum/1RAO PDBsum 1RB0 http://www.ebi.ac.uk/pdbsum/1RB0 PDBsum 1RTZ http://www.ebi.ac.uk/pdbsum/1RTZ PDBsum 1RU1 http://www.ebi.ac.uk/pdbsum/1RU1 PDBsum 1RU2 http://www.ebi.ac.uk/pdbsum/1RU2 PDBsum 1TMJ http://www.ebi.ac.uk/pdbsum/1TMJ PDBsum 1TMM http://www.ebi.ac.uk/pdbsum/1TMM PDBsum 2F63 http://www.ebi.ac.uk/pdbsum/2F63 PDBsum 2F65 http://www.ebi.ac.uk/pdbsum/2F65 PDBsum 3HCX http://www.ebi.ac.uk/pdbsum/3HCX PDBsum 3HD1 http://www.ebi.ac.uk/pdbsum/3HD1 PDBsum 3HD2 http://www.ebi.ac.uk/pdbsum/3HD2 PDBsum 3HSD http://www.ebi.ac.uk/pdbsum/3HSD PDBsum 3HSG http://www.ebi.ac.uk/pdbsum/3HSG PDBsum 3HSJ http://www.ebi.ac.uk/pdbsum/3HSJ PDBsum 3HSZ http://www.ebi.ac.uk/pdbsum/3HSZ PDBsum 3HT0 http://www.ebi.ac.uk/pdbsum/3HT0 PDBsum 3ILI http://www.ebi.ac.uk/pdbsum/3ILI PDBsum 3ILJ http://www.ebi.ac.uk/pdbsum/3ILJ PDBsum 3ILL http://www.ebi.ac.uk/pdbsum/3ILL PDBsum 3ILO http://www.ebi.ac.uk/pdbsum/3ILO PDBsum 3IP0 http://www.ebi.ac.uk/pdbsum/3IP0 PDBsum 3KUE http://www.ebi.ac.uk/pdbsum/3KUE PDBsum 3KUG http://www.ebi.ac.uk/pdbsum/3KUG PDBsum 3KUH http://www.ebi.ac.uk/pdbsum/3KUH PDBsum 3UD5 http://www.ebi.ac.uk/pdbsum/3UD5 PDBsum 3UDE http://www.ebi.ac.uk/pdbsum/3UDE PDBsum 3UDV http://www.ebi.ac.uk/pdbsum/3UDV PDBsum 4F7V http://www.ebi.ac.uk/pdbsum/4F7V PDBsum 4M5G http://www.ebi.ac.uk/pdbsum/4M5G PDBsum 4M5H http://www.ebi.ac.uk/pdbsum/4M5H PDBsum 4M5I http://www.ebi.ac.uk/pdbsum/4M5I PDBsum 4M5J http://www.ebi.ac.uk/pdbsum/4M5J PDBsum 4M5K http://www.ebi.ac.uk/pdbsum/4M5K PDBsum 4M5L http://www.ebi.ac.uk/pdbsum/4M5L PDBsum 4M5M http://www.ebi.ac.uk/pdbsum/4M5M PDBsum 4M5N http://www.ebi.ac.uk/pdbsum/4M5N PDBsum 5ETK http://www.ebi.ac.uk/pdbsum/5ETK PDBsum 5ETL http://www.ebi.ac.uk/pdbsum/5ETL PDBsum 5ETM http://www.ebi.ac.uk/pdbsum/5ETM PDBsum 5ETN http://www.ebi.ac.uk/pdbsum/5ETN PDBsum 5ETO http://www.ebi.ac.uk/pdbsum/5ETO PDBsum 5ETP http://www.ebi.ac.uk/pdbsum/5ETP PROSITE PS00794 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00794 PSORT swissprot:HPPK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HPPK_ECOLI PSORT-B swissprot:HPPK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HPPK_ECOLI PSORT2 swissprot:HPPK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HPPK_ECOLI Pfam PF01288 http://pfam.xfam.org/family/PF01288 Phobius swissprot:HPPK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HPPK_ECOLI PhylomeDB P26281 http://phylomedb.org/?seqid=P26281 ProteinModelPortal P26281 http://www.proteinmodelportal.org/query/uniprot/P26281 PubMed 10378268 http://www.ncbi.nlm.nih.gov/pubmed/10378268 PubMed 10452528 http://www.ncbi.nlm.nih.gov/pubmed/10452528 PubMed 1325970 http://www.ncbi.nlm.nih.gov/pubmed/1325970 PubMed 1657875 http://www.ncbi.nlm.nih.gov/pubmed/1657875 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2537812 http://www.ncbi.nlm.nih.gov/pubmed/2537812 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414684 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414684 RefSeq WP_000215139 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000215139 SMR P26281 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P26281 STRING 511145.b0142 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0142&targetmode=cogs STRING COG0801 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0801&targetmode=cogs SUPFAM SSF55083 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55083 TIGRFAMs TIGR01498 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01498 UniProtKB HPPK_ECOLI http://www.uniprot.org/uniprot/HPPK_ECOLI UniProtKB-AC P26281 http://www.uniprot.org/uniprot/P26281 charge swissprot:HPPK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HPPK_ECOLI eggNOG COG0801 http://eggnogapi.embl.de/nog_data/html/tree/COG0801 eggNOG ENOG4105K8U http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K8U epestfind swissprot:HPPK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HPPK_ECOLI garnier swissprot:HPPK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HPPK_ECOLI helixturnhelix swissprot:HPPK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HPPK_ECOLI hmoment swissprot:HPPK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HPPK_ECOLI iep swissprot:HPPK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HPPK_ECOLI inforesidue swissprot:HPPK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HPPK_ECOLI octanol swissprot:HPPK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HPPK_ECOLI pepcoil swissprot:HPPK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HPPK_ECOLI pepdigest swissprot:HPPK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HPPK_ECOLI pepinfo swissprot:HPPK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HPPK_ECOLI pepnet swissprot:HPPK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HPPK_ECOLI pepstats swissprot:HPPK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HPPK_ECOLI pepwheel swissprot:HPPK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HPPK_ECOLI pepwindow swissprot:HPPK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HPPK_ECOLI sigcleave swissprot:HPPK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HPPK_ECOLI ## Database ID URL or Descriptions # DISRUPTION PHENOTYPE Inactivation results in increased initial adhesion and biofilm formation. {ECO:0000269|PubMed 16452414}. # DOMAIN RFAH_ECOLI The N-terminal domain contains a vast hydrophobic cavity that is buried by the C-terminal domain. This cavity may bind the RNAP and become unmasked only upon binding to the nontemplate DNA strand. {ECO 0000269|PubMed 17434131}. # EcoGene EG10839 rfaH # FUNCTION RFAH_ECOLI Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components. RfaH is recruited into a multi-component RNA polymerase complex by the ops element, which is a short conserved DNA sequence located downstream of the main promoter of these operons. Once bound, RfaH suppresses pausing and inhibits Rho- dependent and intrinsic termination at a subset of sites. Termination signals are bypassed, which allows complete synthesis of long RNA chains. Enhances expression of several operons involved in synthesis of lipopolysaccharides, exopolysaccharides, hemolysin, and sex factor. Also negatively controls expression and surface presentation of AG43 and possibly another AG43-independent factor that mediates cell-cell interactions and biofilm formation. {ECO 0000255|HAMAP-Rule MF_00951, ECO 0000269|PubMed 10660066, ECO 0000269|PubMed 11983161, ECO 0000269|PubMed 12007406, ECO 0000269|PubMed 1584020, ECO 0000269|PubMed 16452414, ECO 0000269|PubMed 8606157, ECO 0000269|PubMed 8951819, ECO 0000269|PubMed 9171395, ECO 0000269|PubMed 9426123}. # GO_function GO:0001000 bacterial-type RNA polymerase core enzyme binding; IDA:EcoCyc. # GO_function GO:0001073 transcription antitermination factor activity, DNA binding; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008494 translation activator activity; IMP:EcoCyc. # GO_process GO:0001124 transcription elongation from bacterial-type RNA polymerase promoter; IDA:EcoCyc. # GO_process GO:0031564 transcription antitermination; IDA:EcoCyc. # GO_process GO:0045727 positive regulation of translation; IMP:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0019899 enzyme binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 2.30.30.30 -; 1. # Gene3D 3.30.70.940 -; 1. # HAMAP MF_00951 RfaH # IntAct P0AFW0 7 # InterPro IPR006645 NGN_dom # InterPro IPR010215 Transcription_antiterm_RfaH # InterPro IPR014722 Rib_L2_dom2 # KEGG_Brite ko03000 Transcription factors # Organism RFAH_ECOLI Escherichia coli (strain K12) # PATRIC 32123181 VBIEscCol129921_3956 # PDB 2OUG X-ray; 2.10 A; A/B/C/D=1-162 # PIR S30732 S30732 # Pfam PF02357 NusG # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Transcription antitermination protein RfaH {ECO:0000255|HAMAP-Rule MF_00951} # RefSeq NP_418284 NC_000913.3 # RefSeq WP_001192396 NZ_LN832404.1 # SIMILARITY Belongs to the RfaH family. {ECO:0000255|HAMAP- Rule MF_00951}. # SMART SM00738 NGN # SUBUNIT RFAH_ECOLI Interacts with both the nontemplate DNA and the RNA polymerase (RNAP). Monomer in solution. {ECO 0000255|HAMAP- Rule MF_00951, ECO 0000269|PubMed 12007406, ECO 0000269|PubMed 17434131}. # SUPFAM SSF82679 SSF82679 # TIGRFAMs TIGR01955 RfaH # eggNOG COG0250 LUCA # eggNOG ENOG4105MDZ Bacteria BLAST swissprot:RFAH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RFAH_ECOLI BioCyc ECOL316407:JW3818-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3818-MONOMER BioCyc EcoCyc:EG10839-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10839-MONOMER COG COG0250 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0250 DOI 10.1007/PL00008648 http://dx.doi.org/10.1007/PL00008648 DOI 10.1016/S0092-8674(02)00724-9 http://dx.doi.org/10.1016/S0092-8674(02)00724-9 DOI 10.1016/S1097-2765(02)00516-6 http://dx.doi.org/10.1016/S1097-2765(02)00516-6 DOI 10.1016/j.molcel.2007.02.021 http://dx.doi.org/10.1016/j.molcel.2007.02.021 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1996.d01-1726.x http://dx.doi.org/10.1046/j.1365-2958.1996.d01-1726.x DOI 10.1046/j.1365-2958.1997.6432014.x http://dx.doi.org/10.1046/j.1365-2958.1997.6432014.x DOI 10.1111/j.1365-2958.1992.tb02166.x http://dx.doi.org/10.1111/j.1365-2958.1992.tb02166.x DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.188.4.1316-1331.2006 http://dx.doi.org/10.1128/JB.188.4.1316-1331.2006 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL M94889 http://www.ebi.ac.uk/ena/data/view/M94889 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X65013 http://www.ebi.ac.uk/ena/data/view/X65013 EchoBASE EB0832 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0832 EcoGene EG10839 http://www.ecogene.org/geneInfo.php?eg_id=EG10839 EnsemblBacteria AAC76845 http://www.ensemblgenomes.org/id/AAC76845 EnsemblBacteria AAC76845 http://www.ensemblgenomes.org/id/AAC76845 EnsemblBacteria BAE77461 http://www.ensemblgenomes.org/id/BAE77461 EnsemblBacteria BAE77461 http://www.ensemblgenomes.org/id/BAE77461 EnsemblBacteria BAE77461 http://www.ensemblgenomes.org/id/BAE77461 EnsemblBacteria b3842 http://www.ensemblgenomes.org/id/b3842 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0001000 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001000 GO_function GO:0001073 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001073 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0008494 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008494 GO_process GO:0001124 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001124 GO_process GO:0031564 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031564 GO_process GO:0045727 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045727 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0019899 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 2.30.30.30 http://www.cathdb.info/version/latest/superfamily/2.30.30.30 Gene3D 3.30.70.940 http://www.cathdb.info/version/latest/superfamily/3.30.70.940 GeneID 948327 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948327 HAMAP MF_00951 http://hamap.expasy.org/unirule/MF_00951 HOGENOM HOG000272711 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000272711&db=HOGENOM6 InParanoid P0AFW0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFW0 IntAct P0AFW0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFW0* InterPro IPR006645 http://www.ebi.ac.uk/interpro/entry/IPR006645 InterPro IPR010215 http://www.ebi.ac.uk/interpro/entry/IPR010215 InterPro IPR014722 http://www.ebi.ac.uk/interpro/entry/IPR014722 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW3818 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3818 KEGG_Gene eco:b3842 http://www.genome.jp/dbget-bin/www_bget?eco:b3842 KEGG_Orthology KO:K05785 http://www.genome.jp/dbget-bin/www_bget?KO:K05785 OMA NQGVECF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NQGVECF PDB 2OUG http://www.ebi.ac.uk/pdbe-srv/view/entry/2OUG PDBsum 2OUG http://www.ebi.ac.uk/pdbsum/2OUG PSORT swissprot:RFAH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RFAH_ECOLI PSORT-B swissprot:RFAH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RFAH_ECOLI PSORT2 swissprot:RFAH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RFAH_ECOLI Pfam PF02357 http://pfam.xfam.org/family/PF02357 Phobius swissprot:RFAH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RFAH_ECOLI ProteinModelPortal P0AFW0 http://www.proteinmodelportal.org/query/uniprot/P0AFW0 PubMed 10660066 http://www.ncbi.nlm.nih.gov/pubmed/10660066 PubMed 11983161 http://www.ncbi.nlm.nih.gov/pubmed/11983161 PubMed 12007406 http://www.ncbi.nlm.nih.gov/pubmed/12007406 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 1584020 http://www.ncbi.nlm.nih.gov/pubmed/1584020 PubMed 16452414 http://www.ncbi.nlm.nih.gov/pubmed/16452414 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17434131 http://www.ncbi.nlm.nih.gov/pubmed/17434131 PubMed 8606157 http://www.ncbi.nlm.nih.gov/pubmed/8606157 PubMed 8951819 http://www.ncbi.nlm.nih.gov/pubmed/8951819 PubMed 9171395 http://www.ncbi.nlm.nih.gov/pubmed/9171395 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9426123 http://www.ncbi.nlm.nih.gov/pubmed/9426123 RefSeq NP_418284 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418284 RefSeq WP_001192396 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001192396 SMART SM00738 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00738 SMR P0AFW0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFW0 STRING 511145.b3842 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3842&targetmode=cogs STRING COG0250 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0250&targetmode=cogs SUPFAM SSF82679 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF82679 TIGRFAMs TIGR01955 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01955 UniProtKB RFAH_ECOLI http://www.uniprot.org/uniprot/RFAH_ECOLI UniProtKB-AC P0AFW0 http://www.uniprot.org/uniprot/P0AFW0 charge swissprot:RFAH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RFAH_ECOLI eggNOG COG0250 http://eggnogapi.embl.de/nog_data/html/tree/COG0250 eggNOG ENOG4105MDZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105MDZ epestfind swissprot:RFAH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RFAH_ECOLI garnier swissprot:RFAH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RFAH_ECOLI helixturnhelix swissprot:RFAH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RFAH_ECOLI hmoment swissprot:RFAH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RFAH_ECOLI iep swissprot:RFAH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RFAH_ECOLI inforesidue swissprot:RFAH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RFAH_ECOLI octanol swissprot:RFAH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RFAH_ECOLI pepcoil swissprot:RFAH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RFAH_ECOLI pepdigest swissprot:RFAH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RFAH_ECOLI pepinfo swissprot:RFAH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RFAH_ECOLI pepnet swissprot:RFAH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RFAH_ECOLI pepstats swissprot:RFAH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RFAH_ECOLI pepwheel swissprot:RFAH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RFAH_ECOLI pepwindow swissprot:RFAH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RFAH_ECOLI sigcleave swissprot:RFAH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RFAH_ECOLI ## Database ID URL or Descriptions # AltName PPSA_ECOLI Pyruvate, water dikinase # BIOPHYSICOCHEMICAL PROPERTIES PPSA_ECOLI Kinetic parameters KM=0.083 mM for pyruvate {ECO 0000269|PubMed 4319237}; KM=0.028 mM for ATP {ECO 0000269|PubMed 4319237}; KM=10.4 mM for phosphate {ECO 0000269|PubMed 4319237}; # BRENDA 2.7.9 2026 # CATALYTIC ACTIVITY PPSA_ECOLI ATP + pyruvate + H(2)O = AMP + phosphoenolpyruvate + phosphate. {ECO 0000269|PubMed 4293109, ECO 0000269|PubMed 4319237}. # COFACTOR PPSA_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 4319237}; # DOMAIN PPSA_ECOLI The N-terminal domain contains the ATP/Pi binding site, the central domain the pyrophosphate/phosphate carrier histidine, and the C-terminal domain the pyruvate binding site. {ECO 0000250}. # ENZYME REGULATION Activated by a Pi-dependent pyrophosphorylation and inactivated by an ADP-dependent phosphorylation on a regulatory threonine. Both reactions are mediated by the bifunctional serine/threonine kinase and phosphorylase PpsR. {ECO:0000269|PubMed 20044937}. # EcoGene EG10759 pps # FUNCTION PPSA_ECOLI Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate. {ECO 0000269|PubMed 4319237}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0008986 pyruvate, water dikinase activity; IDA:EcoCyc. # GO_process GO:0006090 pyruvate metabolic process; IEA:InterPro. # GO_process GO:0006094 gluconeogenesis; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.60 -; 1. # Gene3D 3.30.1490.20 -; 1. # Gene3D 3.30.470.20 -; 1. # Gene3D 3.50.30.10 -; 1. # IntAct P23538 6 # InterPro IPR000121 PEP_util_C # InterPro IPR002192 PPDK_PEP-bd # InterPro IPR006319 PEP_synth # InterPro IPR008279 PEP-util_enz_mobile_dom # InterPro IPR013815 ATP_grasp_subdomain_1 # InterPro IPR013816 ATP_grasp_subdomain_2 # InterPro IPR015813 Pyrv/PenolPyrv_Kinase-like_dom # InterPro IPR018274 PEP_util_AS # InterPro IPR023151 PEP_util_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00620 Pyruvate metabolism # KEGG_Pathway ko00680 Methane metabolism # KEGG_Pathway ko00720 Carbon fixation pathways in prokaryotes # MISCELLANEOUS The reaction takes place in three steps, mediated by a phosphocarrier histidine residue located on the surface of the central domain. The two first partial reactions are catalyzed at an active site located on the N-terminal domain, and the third partial reaction is catalyzed at an active site located on the C- terminal domain. For catalytic turnover, the central domain swivels from the concave surface of the N-terminal domain to that of the C-terminal domain (By similarity). {ECO 0000250}. # Organism PPSA_ECOLI Escherichia coli (strain K12) # PATHWAY PPSA_ECOLI Carbohydrate biosynthesis; gluconeogenesis. # PATRIC 32118710 VBIEscCol129921_1773 # PIR S20554 S20554 # PIRSF PIRSF000854 PEP_synthase # PROSITE PS00370 PEP_ENZYMES_PHOS_SITE # PROSITE PS00742 PEP_ENZYMES_2 # Pfam PF00391 PEP-utilizers # Pfam PF01326 PPDK_N # Pfam PF02896 PEP-utilizers_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PPSA_ECOLI Phosphoenolpyruvate synthase # RefSeq NP_416217 NC_000913.3 # RefSeq WP_000069375 NZ_LN832404.1 # SIMILARITY Belongs to the PEP-utilizing enzyme family. {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 16880}. # SUPFAM SSF51621 SSF51621 # SUPFAM SSF52009 SSF52009 # TIGRFAMs TIGR01418 PEP_synth # eggNOG COG0574 LUCA # eggNOG ENOG4108HRN Bacteria BLAST swissprot:PPSA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PPSA_ECOLI BioCyc ECOL316407:JW1692-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1692-MONOMER BioCyc EcoCyc:PEPSYNTH-MONOMER http://biocyc.org/getid?id=EcoCyc:PEPSYNTH-MONOMER BioCyc MetaCyc:PEPSYNTH-MONOMER http://biocyc.org/getid?id=MetaCyc:PEPSYNTH-MONOMER COG COG0574 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0574 DIP DIP-10552N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10552N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1186/1471-2091-11-1 http://dx.doi.org/10.1186/1471-2091-11-1 EC_number EC:2.7.9.2 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.9.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M69116 http://www.ebi.ac.uk/ena/data/view/M69116 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X59381 http://www.ebi.ac.uk/ena/data/view/X59381 ENZYME 2.7.9.2 http://enzyme.expasy.org/EC/2.7.9.2 EchoBASE EB0752 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0752 EcoGene EG10759 http://www.ecogene.org/geneInfo.php?eg_id=EG10759 EnsemblBacteria AAC74772 http://www.ensemblgenomes.org/id/AAC74772 EnsemblBacteria AAC74772 http://www.ensemblgenomes.org/id/AAC74772 EnsemblBacteria BAA15471 http://www.ensemblgenomes.org/id/BAA15471 EnsemblBacteria BAA15471 http://www.ensemblgenomes.org/id/BAA15471 EnsemblBacteria BAA15471 http://www.ensemblgenomes.org/id/BAA15471 EnsemblBacteria b1702 http://www.ensemblgenomes.org/id/b1702 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008986 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008986 GO_process GO:0006090 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006090 GO_process GO:0006094 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006094 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.60 http://www.cathdb.info/version/latest/superfamily/3.20.20.60 Gene3D 3.30.1490.20 http://www.cathdb.info/version/latest/superfamily/3.30.1490.20 Gene3D 3.30.470.20 http://www.cathdb.info/version/latest/superfamily/3.30.470.20 Gene3D 3.50.30.10 http://www.cathdb.info/version/latest/superfamily/3.50.30.10 GeneID 946209 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946209 HOGENOM HOG000230913 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230913&db=HOGENOM6 InParanoid P23538 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23538 IntAct P23538 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P23538* IntEnz 2.7.9.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.9.2 InterPro IPR000121 http://www.ebi.ac.uk/interpro/entry/IPR000121 InterPro IPR002192 http://www.ebi.ac.uk/interpro/entry/IPR002192 InterPro IPR006319 http://www.ebi.ac.uk/interpro/entry/IPR006319 InterPro IPR008279 http://www.ebi.ac.uk/interpro/entry/IPR008279 InterPro IPR013815 http://www.ebi.ac.uk/interpro/entry/IPR013815 InterPro IPR013816 http://www.ebi.ac.uk/interpro/entry/IPR013816 InterPro IPR015813 http://www.ebi.ac.uk/interpro/entry/IPR015813 InterPro IPR018274 http://www.ebi.ac.uk/interpro/entry/IPR018274 InterPro IPR023151 http://www.ebi.ac.uk/interpro/entry/IPR023151 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1692 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1692 KEGG_Gene eco:b1702 http://www.genome.jp/dbget-bin/www_bget?eco:b1702 KEGG_Orthology KO:K01007 http://www.genome.jp/dbget-bin/www_bget?KO:K01007 KEGG_Pathway ko00620 http://www.genome.jp/kegg-bin/show_pathway?ko00620 KEGG_Pathway ko00680 http://www.genome.jp/kegg-bin/show_pathway?ko00680 KEGG_Pathway ko00720 http://www.genome.jp/kegg-bin/show_pathway?ko00720 KEGG_Reaction rn:R00199 http://www.genome.jp/dbget-bin/www_bget?rn:R00199 OMA MVIEKHY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MVIEKHY PROSITE PS00370 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00370 PROSITE PS00742 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00742 PSORT swissprot:PPSA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PPSA_ECOLI PSORT-B swissprot:PPSA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PPSA_ECOLI PSORT2 swissprot:PPSA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PPSA_ECOLI Pfam PF00391 http://pfam.xfam.org/family/PF00391 Pfam PF01326 http://pfam.xfam.org/family/PF01326 Pfam PF02896 http://pfam.xfam.org/family/PF02896 Phobius swissprot:PPSA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PPSA_ECOLI PhylomeDB P23538 http://phylomedb.org/?seqid=P23538 ProteinModelPortal P23538 http://www.proteinmodelportal.org/query/uniprot/P23538 PubMed 1310524 http://www.ncbi.nlm.nih.gov/pubmed/1310524 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16880 http://www.ncbi.nlm.nih.gov/pubmed/16880 PubMed 20044937 http://www.ncbi.nlm.nih.gov/pubmed/20044937 PubMed 4293109 http://www.ncbi.nlm.nih.gov/pubmed/4293109 PubMed 4319237 http://www.ncbi.nlm.nih.gov/pubmed/4319237 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_416217 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416217 RefSeq WP_000069375 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000069375 SMR P23538 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P23538 STRING 511145.b1702 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1702&targetmode=cogs STRING COG0574 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0574&targetmode=cogs SUPFAM SSF51621 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51621 SUPFAM SSF52009 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52009 SWISS-2DPAGE P23538 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P23538 TIGRFAMs TIGR01418 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01418 UniProtKB PPSA_ECOLI http://www.uniprot.org/uniprot/PPSA_ECOLI UniProtKB-AC P23538 http://www.uniprot.org/uniprot/P23538 charge swissprot:PPSA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PPSA_ECOLI eggNOG COG0574 http://eggnogapi.embl.de/nog_data/html/tree/COG0574 eggNOG ENOG4108HRN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108HRN epestfind swissprot:PPSA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PPSA_ECOLI garnier swissprot:PPSA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PPSA_ECOLI helixturnhelix swissprot:PPSA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PPSA_ECOLI hmoment swissprot:PPSA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PPSA_ECOLI iep swissprot:PPSA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PPSA_ECOLI inforesidue swissprot:PPSA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PPSA_ECOLI octanol swissprot:PPSA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PPSA_ECOLI pepcoil swissprot:PPSA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PPSA_ECOLI pepdigest swissprot:PPSA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PPSA_ECOLI pepinfo swissprot:PPSA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PPSA_ECOLI pepnet swissprot:PPSA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PPSA_ECOLI pepstats swissprot:PPSA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PPSA_ECOLI pepwheel swissprot:PPSA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PPSA_ECOLI pepwindow swissprot:PPSA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PPSA_ECOLI sigcleave swissprot:PPSA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PPSA_ECOLI ## Database ID URL or Descriptions # EcoGene EG14427 ypaA # Organism YPAA_ECOLI Escherichia coli (strain K12) # Proteomes UP000000625 Chromosome # RecName YPAA_ECOLI Uncharacterized protein YpaA # RefSeq WP_000150333 NZ_LN832404.1 # SIMILARITY Belongs to the YadD/YfaD/YhgA/YjiP family. {ECO 0000305}. # eggNOG COG5464 LUCA BLAST swissprot:YPAA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YPAA_ECOLI DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14427 http://www.ecogene.org/geneInfo.php?eg_id=EG14427 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv OMA QESMHEQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QESMHEQ PSORT swissprot:YPAA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YPAA_ECOLI PSORT-B swissprot:YPAA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YPAA_ECOLI PSORT2 swissprot:YPAA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YPAA_ECOLI Phobius swissprot:YPAA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YPAA_ECOLI ProteinModelPortal V9HVX0 http://www.proteinmodelportal.org/query/uniprot/V9HVX0 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000150333 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000150333 STRING 511145.b4543 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4543&targetmode=cogs UniProtKB YPAA_ECOLI http://www.uniprot.org/uniprot/YPAA_ECOLI UniProtKB-AC V9HVX0 http://www.uniprot.org/uniprot/V9HVX0 charge swissprot:YPAA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YPAA_ECOLI eggNOG COG5464 http://eggnogapi.embl.de/nog_data/html/tree/COG5464 epestfind swissprot:YPAA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YPAA_ECOLI garnier swissprot:YPAA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YPAA_ECOLI helixturnhelix swissprot:YPAA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YPAA_ECOLI hmoment swissprot:YPAA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YPAA_ECOLI iep swissprot:YPAA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YPAA_ECOLI inforesidue swissprot:YPAA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YPAA_ECOLI octanol swissprot:YPAA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YPAA_ECOLI pepcoil swissprot:YPAA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YPAA_ECOLI pepdigest swissprot:YPAA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YPAA_ECOLI pepinfo swissprot:YPAA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YPAA_ECOLI pepnet swissprot:YPAA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YPAA_ECOLI pepstats swissprot:YPAA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YPAA_ECOLI pepwheel swissprot:YPAA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YPAA_ECOLI pepwindow swissprot:YPAA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YPAA_ECOLI sigcleave swissprot:YPAA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YPAA_ECOLI ## Database ID URL or Descriptions # AltName PURR_ECOLI Pur regulon repressor # AltName PURR_ECOLI Purine nucleotide synthesis repressor # BioGrid 4260271 3 # CDD cd01392 HTH_LacI # DOMAIN PURR_ECOLI Consists of two structural and functional domains an N- terminal DNA-binding domain, approximately the first 60 residues, and a larger C-terminal domain, approximately 280 residues, which imparts the function of corepressor binding and oligomerization. # EcoGene EG10800 purR # FUNCTION PURR_ECOLI Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. In addition, it participates in the regulation or coregulation of genes involved in de novo pyrimidine nucleotide biosynthesis, salvage and uptake (pyrC, pyrD, carAB and codBA), and of several genes encoding enzymes necessary for nucleotide and polyamine biosynthesis (prsA, glyA, gcvTHP, speA, glnB). Binds to a 16-bp palindromic sequence located within the promoter region of pur regulon genes. The consensus binding sequence is 5'- ACGCAAACGTTTTCNT-3'. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression. {ECO 0000269|PubMed 1400170, ECO 0000269|PubMed 14741201, ECO 0000269|PubMed 2211500, ECO 0000269|PubMed 2404765}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_process GO:0006164 purine nucleotide biosynthetic process; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-HAMAP. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.260.40 -; 1. # HAMAP MF_01277 HTH_type_PurR # INDUCTION Negatively autoregulated. {ECO:0000269|PubMed 2404765}. # INTERACTION PURR_ECOLI P64503 yebV; NbExp=4; IntAct=EBI-1115258, EBI-9126792; # IntAct P0ACP7 8 # InterPro IPR000843 HTH_LacI # InterPro IPR010982 Lambda_DNA-bd_dom # InterPro IPR023588 Tscrpt_reg_HTH_PurR # InterPro IPR028082 Peripla_BP_I # KEGG_Brite ko03000 Transcription factors # MISCELLANEOUS PURR_ECOLI The corepressors hypoxanthine and guanine bind cooperatively to single PurR sites in each subunit of the dimer, inducing a conformational change which increases the affinity of PurR for its DNA operator sites. # Organism PURR_ECOLI Escherichia coli (strain K12) # PATHWAY PURR_ECOLI Purine metabolism; purine nucleotide biosynthesis [regulation]. # PATRIC 32118622 VBIEscCol129921_1731 # PDB 1BDH X-ray; 2.70 A; A=2-341 # PDB 1BDI X-ray; 3.00 A; A=2-341 # PDB 1DBQ X-ray; 2.20 A; A/B=53-341 # PDB 1JFS X-ray; 2.90 A; A=2-341 # PDB 1JFT X-ray; 2.50 A; A=2-341 # PDB 1JH9 X-ray; 2.55 A; A=2-341 # PDB 1JHZ X-ray; 2.40 A; A/B=53-341 # PDB 1PNR X-ray; 2.70 A; A=2-341 # PDB 1PRU NMR; -; A=1-56 # PDB 1PRV NMR; -; A=1-56 # PDB 1QP0 X-ray; 2.90 A; A=2-341 # PDB 1QP4 X-ray; 3.00 A; A=2-341 # PDB 1QP7 X-ray; 2.90 A; A=2-341 # PDB 1QPZ X-ray; 2.50 A; A=2-341 # PDB 1QQA X-ray; 3.00 A; A=2-341 # PDB 1QQB X-ray; 2.70 A; A=2-341 # PDB 1VPW X-ray; 2.70 A; A=2-341 # PDB 1WET X-ray; 2.60 A; A=2-341 # PDB 1ZAY X-ray; 2.70 A; A=2-341 # PDB 2PUA X-ray; 2.90 A; A=2-341 # PDB 2PUB X-ray; 2.70 A; A=2-341 # PDB 2PUC X-ray; 2.60 A; A=2-341 # PDB 2PUD X-ray; 2.60 A; A=2-341 # PDB 2PUE X-ray; 2.70 A; A=2-341 # PDB 2PUF X-ray; 3.00 A; A=2-341 # PDB 2PUG X-ray; 2.70 A; A=2-341 # PIR A32027 RPECDU # PRINTS PR00036 HTHLACI # PROSITE PS00356 HTH_LACI_1 # PROSITE PS50932 HTH_LACI_2 # Pfam PF00356 LacI # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PURR_ECOLI HTH-type transcriptional repressor PurR # RefSeq NP_416175 NC_000913.3 # RefSeq WP_000190982 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lacI-type DNA-binding domain. {ECO 0000305}. # SMART SM00354 HTH_LACI # SUBUNIT PURR_ECOLI Homodimer. {ECO 0000269|PubMed 11781089, ECO 0000269|PubMed 1400170, ECO 0000269|PubMed 7973627, ECO 0000269|PubMed 9278422, ECO 0000269|PubMed 9628480, ECO 0000269|Ref.17}. # SUPFAM SSF47413 SSF47413 # SUPFAM SSF53822 SSF53822 # eggNOG COG1609 LUCA # eggNOG ENOG4105ETE Bacteria BLAST swissprot:PURR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PURR_ECOLI BioCyc ECOL316407:JW1650-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1650-MONOMER BioCyc EcoCyc:PD00219 http://biocyc.org/getid?id=EcoCyc:PD00219 BioCyc MetaCyc:PD00219 http://biocyc.org/getid?id=MetaCyc:PD00219 COG COG1609 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1609 DIP DIP-35931N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35931N DOI 10.1006/jmbi.1999.2946 http://dx.doi.org/10.1006/jmbi.1999.2946 DOI 10.1016/0092-8674(95)90243-0 http://dx.doi.org/10.1016/0092-8674(95)90243-0 DOI 10.1016/S0969-2126(01)00257-X http://dx.doi.org/10.1016/S0969-2126(01)00257-X DOI 10.1016/j.jmb.2003.12.024 http://dx.doi.org/10.1016/j.jmb.2003.12.024 DOI 10.1021/bi0156660 http://dx.doi.org/10.1021/bi0156660 DOI 10.1021/bi971942s http://dx.doi.org/10.1021/bi971942s DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb0698-436 http://dx.doi.org/10.1038/nsb0698-436 DOI 10.1074/jbc.272.36.22648 http://dx.doi.org/10.1074/jbc.272.36.22648 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1111/j.1432-1033.1990.tb15314.x http://dx.doi.org/10.1111/j.1432-1033.1990.tb15314.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1126/science.7973627 http://dx.doi.org/10.1126/science.7973627 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J04212 http://www.ebi.ac.uk/ena/data/view/J04212 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X51368 http://www.ebi.ac.uk/ena/data/view/X51368 EchoBASE EB0793 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0793 EcoGene EG10800 http://www.ecogene.org/geneInfo.php?eg_id=EG10800 EnsemblBacteria AAC74730 http://www.ensemblgenomes.org/id/AAC74730 EnsemblBacteria AAC74730 http://www.ensemblgenomes.org/id/AAC74730 EnsemblBacteria BAA15424 http://www.ensemblgenomes.org/id/BAA15424 EnsemblBacteria BAA15424 http://www.ensemblgenomes.org/id/BAA15424 EnsemblBacteria BAA15424 http://www.ensemblgenomes.org/id/BAA15424 EnsemblBacteria b1658 http://www.ensemblgenomes.org/id/b1658 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006164 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006164 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.260.40 http://www.cathdb.info/version/latest/superfamily/1.10.260.40 GeneID 945226 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945226 HAMAP MF_01277 http://hamap.expasy.org/unirule/MF_01277 HOGENOM HOG000220180 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220180&db=HOGENOM6 InParanoid P0ACP7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACP7 IntAct P0ACP7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACP7* InterPro IPR000843 http://www.ebi.ac.uk/interpro/entry/IPR000843 InterPro IPR010982 http://www.ebi.ac.uk/interpro/entry/IPR010982 InterPro IPR023588 http://www.ebi.ac.uk/interpro/entry/IPR023588 InterPro IPR028082 http://www.ebi.ac.uk/interpro/entry/IPR028082 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW1650 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1650 KEGG_Gene eco:b1658 http://www.genome.jp/dbget-bin/www_bget?eco:b1658 KEGG_Orthology KO:K03604 http://www.genome.jp/dbget-bin/www_bget?KO:K03604 OMA CSEYPES http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CSEYPES PDB 1BDH http://www.ebi.ac.uk/pdbe-srv/view/entry/1BDH PDB 1BDI http://www.ebi.ac.uk/pdbe-srv/view/entry/1BDI PDB 1DBQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1DBQ PDB 1JFS http://www.ebi.ac.uk/pdbe-srv/view/entry/1JFS PDB 1JFT http://www.ebi.ac.uk/pdbe-srv/view/entry/1JFT PDB 1JH9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1JH9 PDB 1JHZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1JHZ PDB 1PNR http://www.ebi.ac.uk/pdbe-srv/view/entry/1PNR PDB 1PRU http://www.ebi.ac.uk/pdbe-srv/view/entry/1PRU PDB 1PRV http://www.ebi.ac.uk/pdbe-srv/view/entry/1PRV PDB 1QP0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1QP0 PDB 1QP4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1QP4 PDB 1QP7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1QP7 PDB 1QPZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1QPZ PDB 1QQA http://www.ebi.ac.uk/pdbe-srv/view/entry/1QQA PDB 1QQB http://www.ebi.ac.uk/pdbe-srv/view/entry/1QQB PDB 1VPW http://www.ebi.ac.uk/pdbe-srv/view/entry/1VPW PDB 1WET http://www.ebi.ac.uk/pdbe-srv/view/entry/1WET PDB 1ZAY http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZAY PDB 2PUA http://www.ebi.ac.uk/pdbe-srv/view/entry/2PUA PDB 2PUB http://www.ebi.ac.uk/pdbe-srv/view/entry/2PUB PDB 2PUC http://www.ebi.ac.uk/pdbe-srv/view/entry/2PUC PDB 2PUD http://www.ebi.ac.uk/pdbe-srv/view/entry/2PUD PDB 2PUE http://www.ebi.ac.uk/pdbe-srv/view/entry/2PUE PDB 2PUF http://www.ebi.ac.uk/pdbe-srv/view/entry/2PUF PDB 2PUG http://www.ebi.ac.uk/pdbe-srv/view/entry/2PUG PDBsum 1BDH http://www.ebi.ac.uk/pdbsum/1BDH PDBsum 1BDI http://www.ebi.ac.uk/pdbsum/1BDI PDBsum 1DBQ http://www.ebi.ac.uk/pdbsum/1DBQ PDBsum 1JFS http://www.ebi.ac.uk/pdbsum/1JFS PDBsum 1JFT http://www.ebi.ac.uk/pdbsum/1JFT PDBsum 1JH9 http://www.ebi.ac.uk/pdbsum/1JH9 PDBsum 1JHZ http://www.ebi.ac.uk/pdbsum/1JHZ PDBsum 1PNR http://www.ebi.ac.uk/pdbsum/1PNR PDBsum 1PRU http://www.ebi.ac.uk/pdbsum/1PRU PDBsum 1PRV http://www.ebi.ac.uk/pdbsum/1PRV PDBsum 1QP0 http://www.ebi.ac.uk/pdbsum/1QP0 PDBsum 1QP4 http://www.ebi.ac.uk/pdbsum/1QP4 PDBsum 1QP7 http://www.ebi.ac.uk/pdbsum/1QP7 PDBsum 1QPZ http://www.ebi.ac.uk/pdbsum/1QPZ PDBsum 1QQA http://www.ebi.ac.uk/pdbsum/1QQA PDBsum 1QQB http://www.ebi.ac.uk/pdbsum/1QQB PDBsum 1VPW http://www.ebi.ac.uk/pdbsum/1VPW PDBsum 1WET http://www.ebi.ac.uk/pdbsum/1WET PDBsum 1ZAY http://www.ebi.ac.uk/pdbsum/1ZAY PDBsum 2PUA http://www.ebi.ac.uk/pdbsum/2PUA PDBsum 2PUB http://www.ebi.ac.uk/pdbsum/2PUB PDBsum 2PUC http://www.ebi.ac.uk/pdbsum/2PUC PDBsum 2PUD http://www.ebi.ac.uk/pdbsum/2PUD PDBsum 2PUE http://www.ebi.ac.uk/pdbsum/2PUE PDBsum 2PUF http://www.ebi.ac.uk/pdbsum/2PUF PDBsum 2PUG http://www.ebi.ac.uk/pdbsum/2PUG PRINTS PR00036 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00036 PROSITE PS00356 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00356 PROSITE PS50932 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50932 PSORT swissprot:PURR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PURR_ECOLI PSORT-B swissprot:PURR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PURR_ECOLI PSORT2 swissprot:PURR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PURR_ECOLI Pfam PF00356 http://pfam.xfam.org/family/PF00356 Phobius swissprot:PURR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PURR_ECOLI PhylomeDB P0ACP7 http://phylomedb.org/?seqid=P0ACP7 ProteinModelPortal P0ACP7 http://www.proteinmodelportal.org/query/uniprot/P0ACP7 PubMed 10438625 http://www.ncbi.nlm.nih.gov/pubmed/10438625 PubMed 11781089 http://www.ncbi.nlm.nih.gov/pubmed/11781089 PubMed 1400170 http://www.ncbi.nlm.nih.gov/pubmed/1400170 PubMed 14741201 http://www.ncbi.nlm.nih.gov/pubmed/14741201 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2211500 http://www.ncbi.nlm.nih.gov/pubmed/2211500 PubMed 2404765 http://www.ncbi.nlm.nih.gov/pubmed/2404765 PubMed 3058704 http://www.ncbi.nlm.nih.gov/pubmed/3058704 PubMed 7553867 http://www.ncbi.nlm.nih.gov/pubmed/7553867 PubMed 7973627 http://www.ncbi.nlm.nih.gov/pubmed/7973627 PubMed 8591032 http://www.ncbi.nlm.nih.gov/pubmed/8591032 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278422 http://www.ncbi.nlm.nih.gov/pubmed/9278422 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9454587 http://www.ncbi.nlm.nih.gov/pubmed/9454587 PubMed 9628480 http://www.ncbi.nlm.nih.gov/pubmed/9628480 RefSeq NP_416175 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416175 RefSeq WP_000190982 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000190982 SMART SM00354 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00354 SMR P0ACP7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACP7 STRING 511145.b1658 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1658&targetmode=cogs STRING COG1609 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1609&targetmode=cogs SUPFAM SSF47413 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47413 SUPFAM SSF53822 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822 UniProtKB PURR_ECOLI http://www.uniprot.org/uniprot/PURR_ECOLI UniProtKB-AC P0ACP7 http://www.uniprot.org/uniprot/P0ACP7 charge swissprot:PURR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PURR_ECOLI eggNOG COG1609 http://eggnogapi.embl.de/nog_data/html/tree/COG1609 eggNOG ENOG4105ETE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ETE epestfind swissprot:PURR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PURR_ECOLI garnier swissprot:PURR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PURR_ECOLI helixturnhelix swissprot:PURR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PURR_ECOLI hmoment swissprot:PURR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PURR_ECOLI iep swissprot:PURR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PURR_ECOLI inforesidue swissprot:PURR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PURR_ECOLI octanol swissprot:PURR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PURR_ECOLI pepcoil swissprot:PURR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PURR_ECOLI pepdigest swissprot:PURR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PURR_ECOLI pepinfo swissprot:PURR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PURR_ECOLI pepnet swissprot:PURR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PURR_ECOLI pepstats swissprot:PURR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PURR_ECOLI pepwheel swissprot:PURR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PURR_ECOLI pepwindow swissprot:PURR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PURR_ECOLI sigcleave swissprot:PURR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PURR_ECOLI ## Database ID URL or Descriptions # AltName GLGX_ECOLI Glycogen operon protein GlgX # BRENDA 3.2.1.33 2026 # BioGrid 4263517 16 # CAZy CBM48 Carbohydrate-Binding Module Family 48 # CAZy GH13 Glycoside Hydrolase Family 13 # EcoGene EG10381 glgX # FUNCTION GLGX_ECOLI Hydrolyzes the alpha-1,6-glucosidic linkages in glycogen which has first been partially depolymerized by phosphorylase. Shows only very little activity with native glycogen. {ECO 0000269|PubMed 8576033}. # GO_function GO:0004133 glycogen debranching enzyme activity; IMP:EcoCyc. # GO_function GO:0004135 amylo-alpha-1,6-glucosidase activity; IDA:EcoCyc. # GO_process GO:0005980 glycogen catabolic process; IMP:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009056 catabolic process # Gene3D 2.60.40.10 -; 1. # Gene3D 3.20.20.80 -; 1. # HAMAP MF_01248 GlgX # IntAct P15067 14 # InterPro IPR004193 Glyco_hydro_13_N # InterPro IPR006047 Glyco_hydro_13_cat_dom # InterPro IPR011837 Glycogen_debranch_GlgX # InterPro IPR013781 Glyco_hydro_catalytic_dom # InterPro IPR013783 Ig-like_fold # InterPro IPR014756 Ig_E-set # InterPro IPR015902 Glyco_hydro_13 # InterPro IPR017853 Glycoside_hydrolase_SF # InterPro IPR022844 Glycogen_debranch_bac # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00500 Starch and sucrose metabolism # Organism GLGX_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10357 PTHR10357 # PATHWAY GLGX_ECOLI Glycan degradation; glycogen degradation. # PATRIC 32122302 VBIEscCol129921_3528 # PDB 2WSK X-ray; 2.25 A; A=1-657 # PIR B65139 BVECGX # Pfam PF00128 Alpha-amylase # Pfam PF02922 CBM_48 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLGX_ECOLI Glycogen debranching enzyme # RefSeq NP_417889 NC_000913.3 # RefSeq WP_000192523 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA98735.1; Type=Erroneous termination; Positions=507; Note=Translated as Gln.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the glycosyl hydrolase 13 family. {ECO 0000305}. # SMART SM00642 Aamy # SUPFAM SSF51445 SSF51445; 2 # SUPFAM SSF81296 SSF81296 # TIGRFAMs TIGR02100 glgX_debranch # eggNOG COG1523 LUCA # eggNOG ENOG4107SS7 Bacteria BLAST swissprot:GLGX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLGX_ECOLI BioCyc ECOL316407:JW3394-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3394-MONOMER BioCyc EcoCyc:EG10381-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10381-MONOMER BioCyc MetaCyc:EG10381-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10381-MONOMER COG COG1523 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1523 DOI 10.1016/0378-1119(88)90208-9 http://dx.doi.org/10.1016/0378-1119(88)90208-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.2.1.- http://www.genome.jp/dbget-bin/www_bget?EC:3.2.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01616 http://www.ebi.ac.uk/ena/data/view/J01616 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 3.2.1.- http://enzyme.expasy.org/EC/3.2.1.- EchoBASE EB0376 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0376 EcoGene EG10381 http://www.ecogene.org/geneInfo.php?eg_id=EG10381 EnsemblBacteria AAC76456 http://www.ensemblgenomes.org/id/AAC76456 EnsemblBacteria AAC76456 http://www.ensemblgenomes.org/id/AAC76456 EnsemblBacteria BAE77861 http://www.ensemblgenomes.org/id/BAE77861 EnsemblBacteria BAE77861 http://www.ensemblgenomes.org/id/BAE77861 EnsemblBacteria BAE77861 http://www.ensemblgenomes.org/id/BAE77861 EnsemblBacteria b3431 http://www.ensemblgenomes.org/id/b3431 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004133 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004133 GO_function GO:0004135 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004135 GO_process GO:0005980 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005980 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 2.60.40.10 http://www.cathdb.info/version/latest/superfamily/2.60.40.10 Gene3D 3.20.20.80 http://www.cathdb.info/version/latest/superfamily/3.20.20.80 GeneID 947941 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947941 HAMAP MF_01248 http://hamap.expasy.org/unirule/MF_01248 HOGENOM HOG000239197 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000239197&db=HOGENOM6 InParanoid P15067 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P15067 IntAct P15067 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P15067* IntEnz 3.2.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.2.1 InterPro IPR004193 http://www.ebi.ac.uk/interpro/entry/IPR004193 InterPro IPR006047 http://www.ebi.ac.uk/interpro/entry/IPR006047 InterPro IPR011837 http://www.ebi.ac.uk/interpro/entry/IPR011837 InterPro IPR013781 http://www.ebi.ac.uk/interpro/entry/IPR013781 InterPro IPR013783 http://www.ebi.ac.uk/interpro/entry/IPR013783 InterPro IPR014756 http://www.ebi.ac.uk/interpro/entry/IPR014756 InterPro IPR015902 http://www.ebi.ac.uk/interpro/entry/IPR015902 InterPro IPR017853 http://www.ebi.ac.uk/interpro/entry/IPR017853 InterPro IPR022844 http://www.ebi.ac.uk/interpro/entry/IPR022844 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3394 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3394 KEGG_Gene eco:b3431 http://www.genome.jp/dbget-bin/www_bget?eco:b3431 KEGG_Orthology KO:K02438 http://www.genome.jp/dbget-bin/www_bget?KO:K02438 KEGG_Pathway ko00500 http://www.genome.jp/kegg-bin/show_pathway?ko00500 KEGG_Reaction rn:R09995 http://www.genome.jp/dbget-bin/www_bget?rn:R09995 OMA WVEECHI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WVEECHI PANTHER PTHR10357 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10357 PDB 2WSK http://www.ebi.ac.uk/pdbe-srv/view/entry/2WSK PDBsum 2WSK http://www.ebi.ac.uk/pdbsum/2WSK PSORT swissprot:GLGX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLGX_ECOLI PSORT-B swissprot:GLGX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLGX_ECOLI PSORT2 swissprot:GLGX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLGX_ECOLI Pfam PF00128 http://pfam.xfam.org/family/PF00128 Pfam PF02922 http://pfam.xfam.org/family/PF02922 Phobius swissprot:GLGX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLGX_ECOLI PhylomeDB P15067 http://phylomedb.org/?seqid=P15067 ProteinModelPortal P15067 http://www.proteinmodelportal.org/query/uniprot/P15067 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2975249 http://www.ncbi.nlm.nih.gov/pubmed/2975249 PubMed 8576033 http://www.ncbi.nlm.nih.gov/pubmed/8576033 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417889 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417889 RefSeq WP_000192523 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000192523 SMART SM00642 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00642 SMR P15067 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P15067 STRING 511145.b3431 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3431&targetmode=cogs STRING COG1523 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1523&targetmode=cogs SUPFAM SSF51445 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51445 SUPFAM SSF81296 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81296 TIGRFAMs TIGR02100 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02100 UniProtKB GLGX_ECOLI http://www.uniprot.org/uniprot/GLGX_ECOLI UniProtKB-AC P15067 http://www.uniprot.org/uniprot/P15067 charge swissprot:GLGX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLGX_ECOLI eggNOG COG1523 http://eggnogapi.embl.de/nog_data/html/tree/COG1523 eggNOG ENOG4107SS7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107SS7 epestfind swissprot:GLGX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLGX_ECOLI garnier swissprot:GLGX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLGX_ECOLI helixturnhelix swissprot:GLGX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLGX_ECOLI hmoment swissprot:GLGX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLGX_ECOLI iep swissprot:GLGX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLGX_ECOLI inforesidue swissprot:GLGX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLGX_ECOLI octanol swissprot:GLGX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLGX_ECOLI pepcoil swissprot:GLGX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLGX_ECOLI pepdigest swissprot:GLGX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLGX_ECOLI pepinfo swissprot:GLGX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLGX_ECOLI pepnet swissprot:GLGX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLGX_ECOLI pepstats swissprot:GLGX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLGX_ECOLI pepwheel swissprot:GLGX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLGX_ECOLI pepwindow swissprot:GLGX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLGX_ECOLI sigcleave swissprot:GLGX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLGX_ECOLI ## Database ID URL or Descriptions # BioGrid 4262771 12 # EcoGene EG10021 yjiA # FUNCTION YJIA_ECOLI Binds GTP. May function as GTP-dependent regulator. {ECO 0000269|PubMed 14696199}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003924 GTPase activity; IDA:EcoCyc. # GO_function GO:0005525 GTP binding; IEA:UniProtKB-KW. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0046914 transition metal ion binding; IDA:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003924 GTPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # Gene3D 3.30.1220.10 -; 1. # Gene3D 3.40.50.300 -; 1. # IntAct P24203 2 # InterPro IPR003495 CobW/HypB/UreG_dom # InterPro IPR011629 Cbl_biosynth_CobW-like_C # InterPro IPR027417 P-loop_NTPase # Organism YJIA_ECOLI Escherichia coli (strain K12) # PATRIC 32124310 VBIEscCol129921_4498 # PDB 1NIJ X-ray; 2.00 A; A=1-318 # PDB 4IXM X-ray; 2.57 A; A/B=1-318 # PDB 4IXN X-ray; 2.05 A; A/B=1-318 # PIR S56578 S56578 # Pfam PF02492 cobW # Pfam PF07683 CobW_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJIA_ECOLI Uncharacterized GTP-binding protein YjiA # RefSeq NP_418772 NC_000913.3 # RefSeq WP_001312515 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97249.1; Type=Frameshift; Positions=22; Evidence={ECO 0000305}; # SIMILARITY Belongs to the SIMIBI class G3E GTPase family. CobW subfamily. {ECO 0000305}. # SIMILARITY Contains 1 cobW C-terminal domain. {ECO 0000305}. # SMART SM00833 CobW_C # SUPFAM SSF52540 SSF52540 # SUPFAM SSF90002 SSF90002 # eggNOG COG0523 LUCA # eggNOG ENOG4105CKI Bacteria BLAST swissprot:YJIA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJIA_ECOLI BioCyc ECOL316407:JW5790-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5790-MONOMER BioCyc EcoCyc:EG10021-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10021-MONOMER BioCyc MetaCyc:EG10021-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10021-MONOMER DIP DIP-12630N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12630N DOI 10.1002/prot.10430 http://dx.doi.org/10.1002/prot.10430 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X54198 http://www.ebi.ac.uk/ena/data/view/X54198 EchoBASE EB0020 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0020 EcoGene EG10021 http://www.ecogene.org/geneInfo.php?eg_id=EG10021 EnsemblBacteria AAC77308 http://www.ensemblgenomes.org/id/AAC77308 EnsemblBacteria AAC77308 http://www.ensemblgenomes.org/id/AAC77308 EnsemblBacteria BAE78342 http://www.ensemblgenomes.org/id/BAE78342 EnsemblBacteria BAE78342 http://www.ensemblgenomes.org/id/BAE78342 EnsemblBacteria BAE78342 http://www.ensemblgenomes.org/id/BAE78342 EnsemblBacteria b4352 http://www.ensemblgenomes.org/id/b4352 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0046914 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046914 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.30.1220.10 http://www.cathdb.info/version/latest/superfamily/3.30.1220.10 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948882 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948882 HOGENOM HOG000182211 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000182211&db=HOGENOM6 InParanoid P24203 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P24203 IntAct P24203 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P24203* InterPro IPR003495 http://www.ebi.ac.uk/interpro/entry/IPR003495 InterPro IPR011629 http://www.ebi.ac.uk/interpro/entry/IPR011629 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Gene ecj:JW5790 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5790 KEGG_Gene eco:b4352 http://www.genome.jp/dbget-bin/www_bget?eco:b4352 OMA LIQSTHC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LIQSTHC PDB 1NIJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1NIJ PDB 4IXM http://www.ebi.ac.uk/pdbe-srv/view/entry/4IXM PDB 4IXN http://www.ebi.ac.uk/pdbe-srv/view/entry/4IXN PDBsum 1NIJ http://www.ebi.ac.uk/pdbsum/1NIJ PDBsum 4IXM http://www.ebi.ac.uk/pdbsum/4IXM PDBsum 4IXN http://www.ebi.ac.uk/pdbsum/4IXN PSORT swissprot:YJIA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJIA_ECOLI PSORT-B swissprot:YJIA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJIA_ECOLI PSORT2 swissprot:YJIA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJIA_ECOLI Pfam PF02492 http://pfam.xfam.org/family/PF02492 Pfam PF07683 http://pfam.xfam.org/family/PF07683 Phobius swissprot:YJIA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJIA_ECOLI PhylomeDB P24203 http://phylomedb.org/?seqid=P24203 ProteinModelPortal P24203 http://www.proteinmodelportal.org/query/uniprot/P24203 PubMed 14696199 http://www.ncbi.nlm.nih.gov/pubmed/14696199 PubMed 1650347 http://www.ncbi.nlm.nih.gov/pubmed/1650347 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418772 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418772 RefSeq WP_001312515 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001312515 SMART SM00833 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00833 SMR P24203 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P24203 STRING 511145.b4352 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4352&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SUPFAM SSF90002 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90002 UniProtKB YJIA_ECOLI http://www.uniprot.org/uniprot/YJIA_ECOLI UniProtKB-AC P24203 http://www.uniprot.org/uniprot/P24203 charge swissprot:YJIA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJIA_ECOLI eggNOG COG0523 http://eggnogapi.embl.de/nog_data/html/tree/COG0523 eggNOG ENOG4105CKI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CKI epestfind swissprot:YJIA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJIA_ECOLI garnier swissprot:YJIA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJIA_ECOLI helixturnhelix swissprot:YJIA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJIA_ECOLI hmoment swissprot:YJIA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJIA_ECOLI iep swissprot:YJIA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJIA_ECOLI inforesidue swissprot:YJIA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJIA_ECOLI octanol swissprot:YJIA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJIA_ECOLI pepcoil swissprot:YJIA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJIA_ECOLI pepdigest swissprot:YJIA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJIA_ECOLI pepinfo swissprot:YJIA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJIA_ECOLI pepnet swissprot:YJIA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJIA_ECOLI pepstats swissprot:YJIA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJIA_ECOLI pepwheel swissprot:YJIA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJIA_ECOLI pepwindow swissprot:YJIA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJIA_ECOLI sigcleave swissprot:YJIA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJIA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259679 173 # CATALYTIC ACTIVITY dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy- alpha-D-glucose + H(2)O. {ECO:0000250|UniProtKB P27830}. # COFACTOR RMLB1_ECOLI Name=NAD(+); Xref=ChEBI CHEBI 57540; Evidence={ECO 0000250|UniProtKB P27830}; Note=Binds 1 NAD(+) per subunit. {ECO 0000250|UniProtKB P27830}; # EcoGene EG12412 rfbB # FUNCTION RMLB1_ECOLI Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction. {ECO 0000250|UniProtKB P27830}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008460 dTDP-glucose 4,6-dehydratase activity; ISS:UniProtKB. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0050662 coenzyme binding; IDA:EcoCyc. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; ISS:UniProtKB. # GO_process GO:0009226 nucleotide-sugar biosynthetic process; IDA:EcoCyc. # GO_process GO:0009243 O antigen biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0019305 dTDP-rhamnose biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0045226 extracellular polysaccharide biosynthetic process; ISS:UniProtKB. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.50.720 -; 1. # IntAct P37759 7 # InterPro IPR005888 dTDP_Gluc_deHydtase # InterPro IPR016040 NAD(P)-bd_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00521 Streptomycin biosynthesis # KEGG_Pathway ko00523 Polyketide sugar unit biosynthesis # KEGG_Pathway ko01055 Biosynthesis of vancomycin group antibiotics # Organism RMLB1_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10366:SF41 PTHR10366:SF41 # PATHWAY Bacterial outer membrane biogenesis; LPS O-antigen biosynthesis. {ECO:0000269|PubMed 7559340}. # PATHWAY Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis. {ECO:0000269|PubMed 7559340}. # PATRIC 32119415 VBIEscCol129921_2118 # PIR H64969 H64969 # Pfam PF16363 GDP_Man_Dehyd # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName dTDP-glucose 4,6-dehydratase 1 {ECO:0000250|UniProtKB P27830} # RefSeq NP_416545 NC_000913.3 # RefSeq WP_000699460 NZ_LN832404.1 # SIMILARITY Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000250|UniProtKB P27830}. # SUPFAM SSF51735 SSF51735 # TIGRFAMs TIGR01181 dTDP_gluc_dehyt # eggNOG COG1088 LUCA # eggNOG ENOG4105C1B Bacteria BLAST swissprot:RMLB1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RMLB1_ECOLI BioCyc ECOL316407:JW2026-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2026-MONOMER BioCyc EcoCyc:DTDPGLUCDEHYDRAT-MONOMER http://biocyc.org/getid?id=EcoCyc:DTDPGLUCDEHYDRAT-MONOMER BioCyc MetaCyc:DTDPGLUCDEHYDRAT-MONOMER http://biocyc.org/getid?id=MetaCyc:DTDPGLUCDEHYDRAT-MONOMER COG COG1088 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1088 DIP DIP-10680N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10680N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.1.46 {ECO:0000250|UniProtKB:P27830} http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.46 {ECO:0000250|UniProtKB:P27830} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U09876 http://www.ebi.ac.uk/ena/data/view/U09876 ENZYME 4.2.1.46 {ECO:0000250|UniProtKB:P27830} http://enzyme.expasy.org/EC/4.2.1.46 {ECO:0000250|UniProtKB:P27830} EchoBASE EB2311 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2311 EcoGene EG12412 http://www.ecogene.org/geneInfo.php?eg_id=EG12412 EnsemblBacteria AAC75102 http://www.ensemblgenomes.org/id/AAC75102 EnsemblBacteria AAC75102 http://www.ensemblgenomes.org/id/AAC75102 EnsemblBacteria BAA15883 http://www.ensemblgenomes.org/id/BAA15883 EnsemblBacteria BAA15883 http://www.ensemblgenomes.org/id/BAA15883 EnsemblBacteria BAA15883 http://www.ensemblgenomes.org/id/BAA15883 EnsemblBacteria b2041 http://www.ensemblgenomes.org/id/b2041 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008460 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008460 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0050662 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050662 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GO_process GO:0009226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009226 GO_process GO:0009243 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009243 GO_process GO:0019305 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019305 GO_process GO:0045226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045226 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 945276 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945276 HOGENOM HOG000168006 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000168006&db=HOGENOM6 InParanoid P37759 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37759 IntAct P37759 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37759* IntEnz 4.2.1.46 {ECO:0000250|UniProtKB:P27830} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.46 {ECO:0000250|UniProtKB:P27830} InterPro IPR005888 http://www.ebi.ac.uk/interpro/entry/IPR005888 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2026 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2026 KEGG_Gene eco:b2041 http://www.genome.jp/dbget-bin/www_bget?eco:b2041 KEGG_Orthology KO:K01710 http://www.genome.jp/dbget-bin/www_bget?KO:K01710 KEGG_Pathway ko00521 http://www.genome.jp/kegg-bin/show_pathway?ko00521 KEGG_Pathway ko00523 http://www.genome.jp/kegg-bin/show_pathway?ko00523 KEGG_Pathway ko01055 http://www.genome.jp/kegg-bin/show_pathway?ko01055 KEGG_Reaction rn:R06513 http://www.genome.jp/dbget-bin/www_bget?rn:R06513 MINT MINT-1302103 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1302103 OMA GGWNEMT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GGWNEMT PANTHER PTHR10366:SF41 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10366:SF41 PSORT swissprot:RMLB1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RMLB1_ECOLI PSORT-B swissprot:RMLB1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RMLB1_ECOLI PSORT2 swissprot:RMLB1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RMLB1_ECOLI Pfam PF16363 http://pfam.xfam.org/family/PF16363 Phobius swissprot:RMLB1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RMLB1_ECOLI PhylomeDB P37759 http://phylomedb.org/?seqid=P37759 ProteinModelPortal P37759 http://www.proteinmodelportal.org/query/uniprot/P37759 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7517391 http://www.ncbi.nlm.nih.gov/pubmed/7517391 PubMed 7559340 http://www.ncbi.nlm.nih.gov/pubmed/7559340 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416545 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416545 RefSeq WP_000699460 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000699460 SMR P37759 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37759 STRING 511145.b2041 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2041&targetmode=cogs STRING COG1088 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1088&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 TIGRFAMs TIGR01181 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01181 UniProtKB RMLB1_ECOLI http://www.uniprot.org/uniprot/RMLB1_ECOLI UniProtKB-AC P37759 http://www.uniprot.org/uniprot/P37759 charge swissprot:RMLB1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RMLB1_ECOLI eggNOG COG1088 http://eggnogapi.embl.de/nog_data/html/tree/COG1088 eggNOG ENOG4105C1B http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C1B epestfind swissprot:RMLB1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RMLB1_ECOLI garnier swissprot:RMLB1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RMLB1_ECOLI helixturnhelix swissprot:RMLB1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RMLB1_ECOLI hmoment swissprot:RMLB1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RMLB1_ECOLI iep swissprot:RMLB1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RMLB1_ECOLI inforesidue swissprot:RMLB1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RMLB1_ECOLI octanol swissprot:RMLB1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RMLB1_ECOLI pepcoil swissprot:RMLB1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RMLB1_ECOLI pepdigest swissprot:RMLB1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RMLB1_ECOLI pepinfo swissprot:RMLB1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RMLB1_ECOLI pepnet swissprot:RMLB1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RMLB1_ECOLI pepstats swissprot:RMLB1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RMLB1_ECOLI pepwheel swissprot:RMLB1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RMLB1_ECOLI pepwindow swissprot:RMLB1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RMLB1_ECOLI sigcleave swissprot:RMLB1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RMLB1_ECOLI ## Database ID URL or Descriptions # BioGrid 4261793 129 # EcoGene EG11156 ppdB # FUNCTION PPDB_ECOLI Not yet known. # InterPro IPR012902 N_methyl_site # InterPro IPR016419 Prepilin_Pept-dep_B_prd # KEGG_Brite ko02044 Secretion system # Organism PPDB_ECOLI Escherichia coli (strain K12) # PATRIC 32121068 VBIEscCol129921_2923 # PIR B65065 QQEC30 # PIRSF PIRSF004525 Pilin_peptidase-dep_B_prd # PROSITE PS00409 PROKAR_NTER_METHYL # Pfam PF07963 N_methyl # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PPDB_ECOLI Prepilin peptidase-dependent protein B # RefSeq NP_417302 NC_000913.3 # RefSeq WP_001144315 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA27601.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # TIGRFAMs TIGR02532 IV_pilin_GFxxxE # eggNOG COG4795 LUCA # eggNOG ENOG4105JCS Bacteria BLAST swissprot:PPDB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PPDB_ECOLI BioCyc ECOL316407:JW5451-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5451-MONOMER BioCyc EcoCyc:EG11156-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11156-MONOMER COG COG4795 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4795 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/14.11.4437 http://dx.doi.org/10.1093/nar/14.11.4437 DOI 10.1111/j.1365-2958.1993.tb01949.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb01949.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 EMBL X03966 http://www.ebi.ac.uk/ena/data/view/X03966 EchoBASE EB1145 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1145 EcoGene EG11156 http://www.ecogene.org/geneInfo.php?eg_id=EG11156 EnsemblBacteria AAC75864 http://www.ensemblgenomes.org/id/AAC75864 EnsemblBacteria AAC75864 http://www.ensemblgenomes.org/id/AAC75864 EnsemblBacteria BAE76894 http://www.ensemblgenomes.org/id/BAE76894 EnsemblBacteria BAE76894 http://www.ensemblgenomes.org/id/BAE76894 EnsemblBacteria BAE76894 http://www.ensemblgenomes.org/id/BAE76894 EnsemblBacteria b2825 http://www.ensemblgenomes.org/id/b2825 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 948985 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948985 HOGENOM HOG000124357 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000124357&db=HOGENOM6 InterPro IPR012902 http://www.ebi.ac.uk/interpro/entry/IPR012902 InterPro IPR016419 http://www.ebi.ac.uk/interpro/entry/IPR016419 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW5451 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5451 KEGG_Gene eco:b2825 http://www.genome.jp/dbget-bin/www_bget?eco:b2825 KEGG_Orthology KO:K02680 http://www.genome.jp/dbget-bin/www_bget?KO:K02680 OMA RAGYCAG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RAGYCAG PROSITE PS00409 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00409 PSORT swissprot:PPDB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PPDB_ECOLI PSORT-B swissprot:PPDB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PPDB_ECOLI PSORT2 swissprot:PPDB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PPDB_ECOLI Pfam PF07963 http://pfam.xfam.org/family/PF07963 Phobius swissprot:PPDB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PPDB_ECOLI ProteinModelPortal P08371 http://www.proteinmodelportal.org/query/uniprot/P08371 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3520484 http://www.ncbi.nlm.nih.gov/pubmed/3520484 PubMed 7934814 http://www.ncbi.nlm.nih.gov/pubmed/7934814 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417302 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417302 RefSeq WP_001144315 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001144315 STRING 511145.b2825 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2825&targetmode=cogs STRING COG4795 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4795&targetmode=cogs TIGRFAMs TIGR02532 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02532 UniProtKB PPDB_ECOLI http://www.uniprot.org/uniprot/PPDB_ECOLI UniProtKB-AC P08371 http://www.uniprot.org/uniprot/P08371 charge swissprot:PPDB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PPDB_ECOLI eggNOG COG4795 http://eggnogapi.embl.de/nog_data/html/tree/COG4795 eggNOG ENOG4105JCS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105JCS epestfind swissprot:PPDB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PPDB_ECOLI garnier swissprot:PPDB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PPDB_ECOLI helixturnhelix swissprot:PPDB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PPDB_ECOLI hmoment swissprot:PPDB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PPDB_ECOLI iep swissprot:PPDB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PPDB_ECOLI inforesidue swissprot:PPDB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PPDB_ECOLI octanol swissprot:PPDB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PPDB_ECOLI pepcoil swissprot:PPDB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PPDB_ECOLI pepdigest swissprot:PPDB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PPDB_ECOLI pepinfo swissprot:PPDB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PPDB_ECOLI pepnet swissprot:PPDB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PPDB_ECOLI pepstats swissprot:PPDB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PPDB_ECOLI pepwheel swissprot:PPDB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PPDB_ECOLI pepwindow swissprot:PPDB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PPDB_ECOLI sigcleave swissprot:PPDB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PPDB_ECOLI ## Database ID URL or Descriptions # FUNCTION IND10_ECOLI Involved in the transposition of the insertion sequence IS2. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006310 DNA recombination; IEA:UniProtKB-KW. # GO_process GO:0015074 DNA integration; IEA:InterPro. # GO_process GO:0032196 transposition; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 3.30.420.10 -; 1. # InterPro IPR001584 Integrase_cat-core # InterPro IPR012337 RNaseH-like_dom # InterPro IPR025948 HTH-like_dom # Organism IND10_ECOLI Escherichia coli (strain K12) # PATRIC 48661345 VBIEscCol107702_1042 # PROSITE PS50994 INTEGRASE # Pfam PF00665 rve # Pfam PF13276 HTH_21 # RecName IND10_ECOLI Transposase InsD for insertion element IS2-10 # SIMILARITY Contains 1 integrase catalytic domain. {ECO:0000255|PROSITE-ProRule PRU00457}. # SUPFAM SSF53098 SSF53098 # eggNOG ENOG4108MVM Bacteria # eggNOG ENOG410Z4Y8 LUCA BLAST swissprot:IND10_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:IND10_ECOLI DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EnsemblBacteria BAA22515 http://www.ensemblgenomes.org/id/BAA22515 EnsemblBacteria BAA22515 http://www.ensemblgenomes.org/id/BAA22515 EnsemblBacteria BAA22515 http://www.ensemblgenomes.org/id/BAA22515 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0015074 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015074 GO_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 3.30.420.10 http://www.cathdb.info/version/latest/superfamily/3.30.420.10 InterPro IPR001584 http://www.ebi.ac.uk/interpro/entry/IPR001584 InterPro IPR012337 http://www.ebi.ac.uk/interpro/entry/IPR012337 InterPro IPR025948 http://www.ebi.ac.uk/interpro/entry/IPR025948 KEGG_Gene ecj:JW5903 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5903 PROSITE PS50994 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50994 PSORT swissprot:IND10_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:IND10_ECOLI PSORT-B swissprot:IND10_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:IND10_ECOLI PSORT2 swissprot:IND10_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:IND10_ECOLI Pfam PF00665 http://pfam.xfam.org/family/PF00665 Pfam PF13276 http://pfam.xfam.org/family/PF13276 Phobius swissprot:IND10_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:IND10_ECOLI PhylomeDB P0CF62 http://phylomedb.org/?seqid=P0CF62 ProteinModelPortal P0CF62 http://www.proteinmodelportal.org/query/uniprot/P0CF62 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 SMR P0CF62 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0CF62 STRING 511145.b4273 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4273&targetmode=cogs SUPFAM SSF53098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098 UniProtKB IND10_ECOLI http://www.uniprot.org/uniprot/IND10_ECOLI UniProtKB-AC P0CF62 http://www.uniprot.org/uniprot/P0CF62 charge swissprot:IND10_ECOLI http://rest.g-language.org/emboss/charge/swissprot:IND10_ECOLI eggNOG ENOG4108MVM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MVM eggNOG ENOG410Z4Y8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Z4Y8 epestfind swissprot:IND10_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:IND10_ECOLI garnier swissprot:IND10_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:IND10_ECOLI helixturnhelix swissprot:IND10_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:IND10_ECOLI hmoment swissprot:IND10_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:IND10_ECOLI iep swissprot:IND10_ECOLI http://rest.g-language.org/emboss/iep/swissprot:IND10_ECOLI inforesidue swissprot:IND10_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:IND10_ECOLI octanol swissprot:IND10_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:IND10_ECOLI pepcoil swissprot:IND10_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:IND10_ECOLI pepdigest swissprot:IND10_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:IND10_ECOLI pepinfo swissprot:IND10_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:IND10_ECOLI pepnet swissprot:IND10_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:IND10_ECOLI pepstats swissprot:IND10_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:IND10_ECOLI pepwheel swissprot:IND10_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:IND10_ECOLI pepwindow swissprot:IND10_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:IND10_ECOLI sigcleave swissprot:IND10_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:IND10_ECOLI ## Database ID URL or Descriptions # BioGrid 4263036 185 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG13047 ygeQ # GO_function GO:0003824 catalytic activity; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # Gene3D 1.50.10.10 -; 2. # InterPro IPR008928 6-hairpin_glycosidase-like # InterPro IPR012341 6hp_glycosidase # Organism YGEQ_ECOLI Escherichia coli (strain K12) # PATRIC 48665162 VBIEscCol107702_2894 # PIR H65069 H65069 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGEQ_ECOLI Putative uncharacterized protein YgeQ # SEQUENCE CAUTION Sequence=BAE76930.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SUPFAM SSF48208 SSF48208 # eggNOG ENOG4108T88 Bacteria # eggNOG ENOG410ZW69 LUCA BLAST swissprot:YGEQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGEQ_ECOLI BioCyc ECOL316407:JW5461-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5461-MONOMER BioCyc EcoCyc:G7483-MONOMER http://biocyc.org/getid?id=EcoCyc:G7483-MONOMER DIP DIP-12155N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12155N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 EchoBASE EB2859 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2859 EcoGene EG13047 http://www.ecogene.org/geneInfo.php?eg_id=EG13047 EnsemblBacteria BAE76930 http://www.ensemblgenomes.org/id/BAE76930 EnsemblBacteria BAE76930 http://www.ensemblgenomes.org/id/BAE76930 EnsemblBacteria BAE76930 http://www.ensemblgenomes.org/id/BAE76930 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003824 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003824 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 Gene3D 1.50.10.10 http://www.cathdb.info/version/latest/superfamily/1.50.10.10 HOGENOM HOG000009556 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009556&db=HOGENOM6 IntAct Q46797 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46797* InterPro IPR008928 http://www.ebi.ac.uk/interpro/entry/IPR008928 InterPro IPR012341 http://www.ebi.ac.uk/interpro/entry/IPR012341 KEGG_Gene ecj:JW5461 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5461 PSORT swissprot:YGEQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGEQ_ECOLI PSORT-B swissprot:YGEQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGEQ_ECOLI PSORT2 swissprot:YGEQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGEQ_ECOLI Phobius swissprot:YGEQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGEQ_ECOLI ProteinModelPortal Q46797 http://www.proteinmodelportal.org/query/uniprot/Q46797 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 STRING 316407.85675677 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85675677&targetmode=cogs SUPFAM SSF48208 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48208 UniProtKB YGEQ_ECOLI http://www.uniprot.org/uniprot/YGEQ_ECOLI UniProtKB-AC Q46797 http://www.uniprot.org/uniprot/Q46797 charge swissprot:YGEQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGEQ_ECOLI eggNOG ENOG4108T88 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108T88 eggNOG ENOG410ZW69 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZW69 epestfind swissprot:YGEQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGEQ_ECOLI garnier swissprot:YGEQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGEQ_ECOLI helixturnhelix swissprot:YGEQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGEQ_ECOLI hmoment swissprot:YGEQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGEQ_ECOLI iep swissprot:YGEQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGEQ_ECOLI inforesidue swissprot:YGEQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGEQ_ECOLI octanol swissprot:YGEQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGEQ_ECOLI pepcoil swissprot:YGEQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGEQ_ECOLI pepdigest swissprot:YGEQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGEQ_ECOLI pepinfo swissprot:YGEQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGEQ_ECOLI pepnet swissprot:YGEQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGEQ_ECOLI pepstats swissprot:YGEQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGEQ_ECOLI pepwheel swissprot:YGEQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGEQ_ECOLI pepwindow swissprot:YGEQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGEQ_ECOLI sigcleave swissprot:YGEQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGEQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4259867 177 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG14327 ylbH # GO_process GO:0097264 self proteolysis; IEA:InterPro. # GOslim_process GO:0008150 biological_process # InterPro IPR001826 RHS # InterPro IPR022385 Rhs_assc_core # Organism YLBH_ECOLI Escherichia coli (strain K12) # PATRIC 48660209 VBIEscCol107702_0498 # PIR B64781 B64781 # PRINTS PR00394 RHSPROTEIN # Pfam PF03527 RHS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YLBH_ECOLI Putative uncharacterized protein YlbH # RefSeq WP_001300714 NZ_LN832404.1 # SIMILARITY Belongs to the RHS family. {ECO 0000305}. # TIGRFAMs TIGR03696 Rhs_assc_core BLAST swissprot:YLBH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YLBH_ECOLI BioCyc ECOL316407:JW0488-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0488-MONOMER BioCyc EcoCyc:G6271-MONOMER http://biocyc.org/getid?id=EcoCyc:G6271-MONOMER DIP DIP-28078N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-28078N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EcoGene EG14327 http://www.ecogene.org/geneInfo.php?eg_id=EG14327 EnsemblBacteria BAE76278 http://www.ensemblgenomes.org/id/BAE76278 EnsemblBacteria BAE76278 http://www.ensemblgenomes.org/id/BAE76278 EnsemblBacteria BAE76278 http://www.ensemblgenomes.org/id/BAE76278 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0097264 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097264 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 HOGENOM HOG000009362 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009362&db=HOGENOM6 IntAct P77759 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77759* InterPro IPR001826 http://www.ebi.ac.uk/interpro/entry/IPR001826 InterPro IPR022385 http://www.ebi.ac.uk/interpro/entry/IPR022385 KEGG_Gene ecj:JW0488 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0488 PRINTS PR00394 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00394 PSORT swissprot:YLBH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YLBH_ECOLI PSORT-B swissprot:YLBH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YLBH_ECOLI PSORT2 swissprot:YLBH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YLBH_ECOLI Pfam PF03527 http://pfam.xfam.org/family/PF03527 Phobius swissprot:YLBH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YLBH_ECOLI ProteinModelPortal P77759 http://www.proteinmodelportal.org/query/uniprot/P77759 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001300714 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300714 SMR P77759 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77759 STRING 316407.85674638 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85674638&targetmode=cogs TIGRFAMs TIGR03696 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03696 UniProtKB YLBH_ECOLI http://www.uniprot.org/uniprot/YLBH_ECOLI UniProtKB-AC P77759 http://www.uniprot.org/uniprot/P77759 charge swissprot:YLBH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YLBH_ECOLI epestfind swissprot:YLBH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YLBH_ECOLI garnier swissprot:YLBH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YLBH_ECOLI helixturnhelix swissprot:YLBH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YLBH_ECOLI hmoment swissprot:YLBH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YLBH_ECOLI iep swissprot:YLBH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YLBH_ECOLI inforesidue swissprot:YLBH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YLBH_ECOLI octanol swissprot:YLBH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YLBH_ECOLI pepcoil swissprot:YLBH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YLBH_ECOLI pepdigest swissprot:YLBH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YLBH_ECOLI pepinfo swissprot:YLBH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YLBH_ECOLI pepnet swissprot:YLBH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YLBH_ECOLI pepstats swissprot:YLBH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YLBH_ECOLI pepwheel swissprot:YLBH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YLBH_ECOLI pepwindow swissprot:YLBH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YLBH_ECOLI sigcleave swissprot:YLBH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YLBH_ECOLI ## Database ID URL or Descriptions # BRENDA 2.7.2 2026 # BioGrid 4262834 6 # CATALYTIC ACTIVITY PGK_ECOLI ATP + 3-phospho-D-glycerate = ADP + 3-phospho- D-glyceroyl phosphate. # CDD cd00318 Phosphoglycerate_kinase # EcoGene EG10703 pgk # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004618 phosphoglycerate kinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0006096 glycolytic process; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.1260 -; 1. # Gene3D 3.40.50.1270 -; 1. # HAMAP MF_00145 Phosphoglyc_kinase # IntAct P0A799 15 # InterPro IPR001576 Phosphoglycerate_kinase # InterPro IPR015824 Phosphoglycerate_kinase_N # InterPro IPR015901 Phosphoglycerate_kinase_C # InterPro IPR015911 Phosphoglycerate_kinase_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00010 Glycolysis / Gluconeogenesis # KEGG_Pathway ko00710 Carbon fixation in photosynthetic organisms # Organism PGK_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11406 PTHR11406 # PATHWAY Carbohydrate degradation; glycolysis; pyruvate from D- glyceraldehyde 3-phosphate step 2/5. # PATRIC 32121266 VBIEscCol129921_3021 # PDB 1ZMR X-ray; 2.40 A; A=1-387 # PIR S04733 TVECG # PIRSF PIRSF000724 Pgk # PRINTS PR00477 PHGLYCKINASE # PROSITE PS00111 PGLYCERATE_KINASE # Pfam PF00162 PGK # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PGK_ECOLI Phosphoglycerate kinase # RefSeq NP_417401 NC_000913.3 # RefSeq WP_000111269 NZ_LN832404.1 # SIMILARITY Belongs to the phosphoglycerate kinase family. {ECO 0000305}. # SUBCELLULAR LOCATION PGK_ECOLI Cytoplasm. # SUBUNIT PGK_ECOLI Monomer. # SUPFAM SSF53748 SSF53748 # UniPathway UPA00109 UER00185 # eggNOG COG0126 LUCA # eggNOG ENOG4105BZA Bacteria BLAST swissprot:PGK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PGK_ECOLI BioCyc ECOL316407:JW2893-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2893-MONOMER BioCyc EcoCyc:PGK http://biocyc.org/getid?id=EcoCyc:PGK BioCyc MetaCyc:PGK http://biocyc.org/getid?id=MetaCyc:PGK COG COG0126 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0126 DIP DIP-36163N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36163N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1998.1726 http://dx.doi.org/10.1006/jmbi.1998.1726 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1111/j.1365-2958.1989.tb00221.x http://dx.doi.org/10.1111/j.1365-2958.1989.tb00221.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.2.3 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.2.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EMBL X14436 http://www.ebi.ac.uk/ena/data/view/X14436 ENZYME 2.7.2.3 http://enzyme.expasy.org/EC/2.7.2.3 EchoBASE EB0697 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0697 EcoGene EG10703 http://www.ecogene.org/geneInfo.php?eg_id=EG10703 EnsemblBacteria AAC75963 http://www.ensemblgenomes.org/id/AAC75963 EnsemblBacteria AAC75963 http://www.ensemblgenomes.org/id/AAC75963 EnsemblBacteria BAE76990 http://www.ensemblgenomes.org/id/BAE76990 EnsemblBacteria BAE76990 http://www.ensemblgenomes.org/id/BAE76990 EnsemblBacteria BAE76990 http://www.ensemblgenomes.org/id/BAE76990 EnsemblBacteria b2926 http://www.ensemblgenomes.org/id/b2926 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004618 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006096 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006096 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.1260 http://www.cathdb.info/version/latest/superfamily/3.40.50.1260 Gene3D 3.40.50.1270 http://www.cathdb.info/version/latest/superfamily/3.40.50.1270 GeneID 947414 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947414 HAMAP MF_00145 http://hamap.expasy.org/unirule/MF_00145 HOGENOM HOG000227107 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000227107&db=HOGENOM6 InParanoid P0A799 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A799 IntAct P0A799 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A799* IntEnz 2.7.2.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.2.3 InterPro IPR001576 http://www.ebi.ac.uk/interpro/entry/IPR001576 InterPro IPR015824 http://www.ebi.ac.uk/interpro/entry/IPR015824 InterPro IPR015901 http://www.ebi.ac.uk/interpro/entry/IPR015901 InterPro IPR015911 http://www.ebi.ac.uk/interpro/entry/IPR015911 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2893 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2893 KEGG_Gene eco:b2926 http://www.genome.jp/dbget-bin/www_bget?eco:b2926 KEGG_Orthology KO:K00927 http://www.genome.jp/dbget-bin/www_bget?KO:K00927 KEGG_Pathway ko00010 http://www.genome.jp/kegg-bin/show_pathway?ko00010 KEGG_Pathway ko00710 http://www.genome.jp/kegg-bin/show_pathway?ko00710 KEGG_Reaction rn:R01512 http://www.genome.jp/dbget-bin/www_bget?rn:R01512 MINT MINT-1229247 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1229247 OMA AGHPVGK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AGHPVGK PANTHER PTHR11406 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11406 PDB 1ZMR http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZMR PDBsum 1ZMR http://www.ebi.ac.uk/pdbsum/1ZMR PRINTS PR00477 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00477 PROSITE PS00111 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00111 PSORT swissprot:PGK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PGK_ECOLI PSORT-B swissprot:PGK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PGK_ECOLI PSORT2 swissprot:PGK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PGK_ECOLI Pfam PF00162 http://pfam.xfam.org/family/PF00162 Phobius swissprot:PGK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PGK_ECOLI PhylomeDB P0A799 http://phylomedb.org/?seqid=P0A799 ProteinModelPortal P0A799 http://www.proteinmodelportal.org/query/uniprot/P0A799 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 2546007 http://www.ncbi.nlm.nih.gov/pubmed/2546007 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 RefSeq NP_417401 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417401 RefSeq WP_000111269 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000111269 SMR P0A799 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A799 STRING 511145.b2926 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2926&targetmode=cogs STRING COG0126 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0126&targetmode=cogs SUPFAM SSF53748 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53748 SWISS-2DPAGE P0A799 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A799 UniProtKB PGK_ECOLI http://www.uniprot.org/uniprot/PGK_ECOLI UniProtKB-AC P0A799 http://www.uniprot.org/uniprot/P0A799 charge swissprot:PGK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PGK_ECOLI eggNOG COG0126 http://eggnogapi.embl.de/nog_data/html/tree/COG0126 eggNOG ENOG4105BZA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZA epestfind swissprot:PGK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PGK_ECOLI garnier swissprot:PGK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PGK_ECOLI helixturnhelix swissprot:PGK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PGK_ECOLI hmoment swissprot:PGK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PGK_ECOLI iep swissprot:PGK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PGK_ECOLI inforesidue swissprot:PGK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PGK_ECOLI octanol swissprot:PGK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PGK_ECOLI pepcoil swissprot:PGK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PGK_ECOLI pepdigest swissprot:PGK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PGK_ECOLI pepinfo swissprot:PGK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PGK_ECOLI pepnet swissprot:PGK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PGK_ECOLI pepstats swissprot:PGK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PGK_ECOLI pepwheel swissprot:PGK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PGK_ECOLI pepwindow swissprot:PGK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PGK_ECOLI sigcleave swissprot:PGK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PGK_ECOLI ## Database ID URL or Descriptions # BioGrid 4259914 3 # CDD cd06261 TM_PBP2 # EcoGene EG12661 gltJ # FUNCTION GLTJ_ECOLI Part of the ABC transporter complex GltIJKL involved in glutamate and aspartate uptake. Probably responsible for the translocation of the substrate across the membrane. {ECO 0000305|PubMed 9593292}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IEA:InterPro. # GO_function GO:0005215 transporter activity; IEA:InterPro. # GO_process GO:0006865 amino acid transport; IEA:UniProtKB-KW. # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006810 transport # Gene3D 1.10.3720.10 -; 1. # IntAct P0AER3 6 # InterPro IPR000515 MetI-like # InterPro IPR010065 AA_ABC_transptr_permease_3TM # InterPro IPR030202 GltJ/AatQ # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00230 Glutamate/aspartate transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism GLTJ_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30085:SF4 PTHR30085:SF4 # PATRIC 32116491 VBIEscCol129921_0685 # PIR D64800 D64800 # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Glutamate/aspartate import permease protein GltJ {ECO 0000305} # RefSeq NP_415187 NC_000913.3 # RefSeq WP_000020941 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION GLTJ_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255}. # SUBUNIT The complex is composed of two ATP-binding proteins (GltL), two transmembrane proteins (GltJ and GltK) and a solute- binding protein (GltI). {ECO:0000305|PubMed 9593292}. # SUPFAM SSF161098 SSF161098 # TCDB 3.A.1.3 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR01726 HEQRo_perm_3TM # eggNOG COG0765 LUCA # eggNOG ENOG4105EAD Bacteria BLAST swissprot:GLTJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLTJ_ECOLI BioCyc ECOL316407:JW0649-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0649-MONOMER BioCyc EcoCyc:GLTJ-MONOMER http://biocyc.org/getid?id=EcoCyc:GLTJ-MONOMER BioCyc MetaCyc:GLTJ-MONOMER http://biocyc.org/getid?id=MetaCyc:GLTJ-MONOMER COG COG0765 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0765 DIP DIP-35965N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35965N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1998.00764.x http://dx.doi.org/10.1046/j.1365-2958.1998.00764.x DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U10981 http://www.ebi.ac.uk/ena/data/view/U10981 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB2527 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2527 EcoGene EG12661 http://www.ecogene.org/geneInfo.php?eg_id=EG12661 EnsemblBacteria AAC73755 http://www.ensemblgenomes.org/id/AAC73755 EnsemblBacteria AAC73755 http://www.ensemblgenomes.org/id/AAC73755 EnsemblBacteria BAA35306 http://www.ensemblgenomes.org/id/BAA35306 EnsemblBacteria BAA35306 http://www.ensemblgenomes.org/id/BAA35306 EnsemblBacteria BAA35306 http://www.ensemblgenomes.org/id/BAA35306 EnsemblBacteria b0654 http://www.ensemblgenomes.org/id/b0654 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_process GO:0006865 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 945443 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945443 HOGENOM HOG000267552 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267552&db=HOGENOM6 InParanoid P0AER3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AER3 IntAct P0AER3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AER3* InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 InterPro IPR010065 http://www.ebi.ac.uk/interpro/entry/IPR010065 InterPro IPR030202 http://www.ebi.ac.uk/interpro/entry/IPR030202 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0649 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0649 KEGG_Gene eco:b0654 http://www.genome.jp/dbget-bin/www_bget?eco:b0654 KEGG_Orthology KO:K10003 http://www.genome.jp/dbget-bin/www_bget?KO:K10003 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 MINT MINT-1264109 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1264109 OMA IMLVMNL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IMLVMNL PANTHER PTHR30085:SF4 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30085:SF4 PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:GLTJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLTJ_ECOLI PSORT-B swissprot:GLTJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLTJ_ECOLI PSORT2 swissprot:GLTJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLTJ_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Phobius swissprot:GLTJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLTJ_ECOLI PhylomeDB P0AER3 http://phylomedb.org/?seqid=P0AER3 ProteinModelPortal P0AER3 http://www.proteinmodelportal.org/query/uniprot/P0AER3 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9593292 http://www.ncbi.nlm.nih.gov/pubmed/9593292 RefSeq NP_415187 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415187 RefSeq WP_000020941 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000020941 SMR P0AER3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AER3 STRING 511145.b0654 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0654&targetmode=cogs STRING COG0765 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0765&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.3 http://www.tcdb.org/search/result.php?tc=3.A.1.3 TIGRFAMs TIGR01726 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01726 UniProtKB GLTJ_ECOLI http://www.uniprot.org/uniprot/GLTJ_ECOLI UniProtKB-AC P0AER3 http://www.uniprot.org/uniprot/P0AER3 charge swissprot:GLTJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLTJ_ECOLI eggNOG COG0765 http://eggnogapi.embl.de/nog_data/html/tree/COG0765 eggNOG ENOG4105EAD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EAD epestfind swissprot:GLTJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLTJ_ECOLI garnier swissprot:GLTJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLTJ_ECOLI helixturnhelix swissprot:GLTJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLTJ_ECOLI hmoment swissprot:GLTJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLTJ_ECOLI iep swissprot:GLTJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLTJ_ECOLI inforesidue swissprot:GLTJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLTJ_ECOLI octanol swissprot:GLTJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLTJ_ECOLI pepcoil swissprot:GLTJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLTJ_ECOLI pepdigest swissprot:GLTJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLTJ_ECOLI pepinfo swissprot:GLTJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLTJ_ECOLI pepnet swissprot:GLTJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLTJ_ECOLI pepstats swissprot:GLTJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLTJ_ECOLI pepwheel swissprot:GLTJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLTJ_ECOLI pepwindow swissprot:GLTJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLTJ_ECOLI sigcleave swissprot:GLTJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLTJ_ECOLI ## Database ID URL or Descriptions # AltName Recombinase A {ECO:0000255|HAMAP-Rule MF_00268} # BioGrid 4259218 403 # CDD cd00983 recA # DISRUPTION PHENOTYPE Triple mazE-mazF-recA mutant cells no longer undergo an apoptotic-like death upon DNA damage characterized by membrane depolarization (PubMed 22412352). # ENZYME REGULATION The rate of DNA-strand exchange is stimulated by RadA. {ECO:0000269|PubMed 26845522}. # EcoGene EG10823 recA # FUNCTION RECA_ECOLI Required for homologous recombination and the bypass of mutagenic DNA lesions by the SOS response. Catalyzes ATP-driven homologous pairing and strand exchange of DNA molecules necessary for DNA recombinational repair. Catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. The SOS response controls an apoptotic-like death (ALD) induced (in the absence of the mazE-mazF toxin-antitoxin module) in response to DNA damaging agents that is mediated by RecA and LexA (PubMed 22412352). {ECO 0000269|PubMed 22412352, ECO 0000269|PubMed 26845522, ECO 0000269|PubMed 7608206, ECO 0000269|PubMed 9230304}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0000150 recombinase activity; IBA:GO_Central. # GO_function GO:0000400 four-way junction DNA binding; IBA:GO_Central. # GO_function GO:0003684 damaged DNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0003690 double-stranded DNA binding; IBA:GO_Central. # GO_function GO:0003697 single-stranded DNA binding; IDA:EcoliWiki. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008094 DNA-dependent ATPase activity; IBA:GO_Central. # GO_process GO:0000730 DNA recombinase assembly; IBA:GO_Central. # GO_process GO:0006310 DNA recombination; IMP:CACAO. # GO_process GO:0006312 mitotic recombination; IBA:GO_Central. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0009432 SOS response; IMP:CACAO. # GO_process GO:0010212 response to ionizing radiation; IMP:EcoCyc. # GO_process GO:0042148 strand invasion; IBA:GO_Central. # GO_process GO:0048870 cell motility; IMP:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0048870 cell motility # GOslim_process GO:0065003 macromolecular complex assembly # Gene3D 3.30.250.10 -; 1. # Gene3D 3.40.50.300 -; 1. # HAMAP MF_00268 RecA # INDUCTION RECA_ECOLI In response to low temperature. Sensitive to temperature through changes in the linking number of the DNA. 5.1- fold induced by hydroxyurea treatment (at protein level) (PubMed 20005847). mRNA levels are repressed in a mazE-mazF- mediated manner (PubMed 22412352). {ECO 0000269|PubMed 20005847, ECO 0000269|PubMed 22412352}. # INTERACTION RECA_ECOLI P23367 mutL; NbExp=3; IntAct=EBI-370331, EBI-554913; # IntAct P0A7G6 28 # InterPro IPR003593 AAA+_ATPase # InterPro IPR013765 DNA_recomb/repair_RecA # InterPro IPR020584 DNA_recomb/repair_RecA_CS # InterPro IPR020587 RecA_monomer-monomer_interface # InterPro IPR020588 RecA_ATP-bd # InterPro IPR023400 RecA_C # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko03440 Homologous recombination # Organism RECA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR22942:SF1 PTHR22942:SF1 # PATRIC 32120796 VBIEscCol129921_2790 # PDB 1AA3 NMR; -; A=269-331 # PDB 1N03 EM; 20.00 A; A/B/C/D/E/F/G=2-353 # PDB 1REA X-ray; 2.70 A; A=2-353 # PDB 1U94 X-ray; 1.90 A; A=2-353 # PDB 1U98 X-ray; 2.00 A; A=2-353 # PDB 1U99 X-ray; 2.60 A; A=2-353 # PDB 1XMS X-ray; 2.10 A; A=2-353 # PDB 1XMV X-ray; 1.90 A; A=2-353 # PDB 2REB X-ray; 2.30 A; A=2-353 # PDB 2REC EM; -; A/B/C/D/E/F=1-353 # PDB 3CMT X-ray; 3.15 A; A/D=2-335 # PDB 3CMU X-ray; 4.20 A; A=2-335 # PDB 3CMV X-ray; 4.30 A; A/B/C/D/E/F/G/H=2-335 # PDB 3CMW X-ray; 2.80 A; A/C=2-335 # PDB 3CMX X-ray; 3.40 A; A/D=2-335 # PDB 4TWZ X-ray; 2.80 A; A=2-353 # PIR G65049 RQECA # PRINTS PR00142 RECA # PROSITE PS00321 RECA_1 # PROSITE PS50162 RECA_2 # PROSITE PS50163 RECA_3 # Pfam PF00154 RecA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Protein RecA {ECO:0000255|HAMAP-Rule MF_00268} # RefSeq NP_417179 NC_000913.3 # RefSeq WP_000963143 NZ_LN832404.1 # SIMILARITY Belongs to the RecA family. {ECO:0000255|HAMAP- Rule MF_00268}. # SMART SM00382 AAA # SUBCELLULAR LOCATION RECA_ECOLI Cytoplasm. # SUBUNIT RECA_ECOLI Polymerizes non-specifically on ssDNA to form filaments; filament formation requires ATP or ATP-gamma-S. Interacts with and activates LexA leading to autocatalytic cleavage of LexA, which derepresses the SOS regulon and activates DNA repair. Interacts with the C-terminus of RecB, facilitating loading of RecA onto ssDNA at chi sites. Interaction is decreased by ATP. {ECO 0000269|PubMed 16483938, ECO 0000269|PubMed 1731246, ECO 0000269|PubMed 1731253}. # SUPFAM SSF52540 SSF52540 # SUPFAM SSF54752 SSF54752 # TIGRFAMs TIGR02012 tigrfam_recA # eggNOG COG0468 LUCA # eggNOG ENOG4105C68 Bacteria BLAST swissprot:RECA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RECA_ECOLI BioCyc ECOL316407:JW2669-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2669-MONOMER BioCyc EcoCyc:EG10823-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10823-MONOMER COG COG0468 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0468 DIP DIP-31832N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31832N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1007/BF00633842 http://dx.doi.org/10.1007/BF00633842 DOI 10.1016/S0092-8674(00)80315-3 http://dx.doi.org/10.1016/S0092-8674(00)80315-3 DOI 10.1016/j.molcel.2006.01.007 http://dx.doi.org/10.1016/j.molcel.2006.01.007 DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/355318a0 http://dx.doi.org/10.1038/355318a0 DOI 10.1038/355374a0 http://dx.doi.org/10.1038/355374a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb0297-101 http://dx.doi.org/10.1038/nsb0297-101 DOI 10.1073/pnas.77.1.313 http://dx.doi.org/10.1073/pnas.77.1.313 DOI 10.1073/pnas.77.5.2611 http://dx.doi.org/10.1073/pnas.77.5.2611 DOI 10.1074/jbc.270.27.16360 http://dx.doi.org/10.1074/jbc.270.27.16360 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1432-1033.1995.0772m.x http://dx.doi.org/10.1111/j.1432-1033.1995.0772m.x DOI 10.1111/j.1432-1033.1995.419_2.x http://dx.doi.org/10.1111/j.1432-1033.1995.419_2.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pbio.1001281 http://dx.doi.org/10.1371/journal.pbio.1001281 DOI 10.7554/eLife.10807 http://dx.doi.org/10.7554/eLife.10807 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00328 http://www.ebi.ac.uk/ena/data/view/V00328 EchoBASE EB0816 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0816 EcoGene EG10823 http://www.ecogene.org/geneInfo.php?eg_id=EG10823 EnsemblBacteria AAC75741 http://www.ensemblgenomes.org/id/AAC75741 EnsemblBacteria AAC75741 http://www.ensemblgenomes.org/id/AAC75741 EnsemblBacteria BAA16561 http://www.ensemblgenomes.org/id/BAA16561 EnsemblBacteria BAA16561 http://www.ensemblgenomes.org/id/BAA16561 EnsemblBacteria BAA16561 http://www.ensemblgenomes.org/id/BAA16561 EnsemblBacteria b2699 http://www.ensemblgenomes.org/id/b2699 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000150 GO_function GO:0000400 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000400 GO_function GO:0003684 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003684 GO_function GO:0003690 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003690 GO_function GO:0003697 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003697 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008094 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008094 GO_process GO:0000730 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000730 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0006312 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006312 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0009432 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009432 GO_process GO:0010212 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010212 GO_process GO:0042148 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042148 GO_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 GOslim_process GO:0065003 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0065003 Gene3D 3.30.250.10 http://www.cathdb.info/version/latest/superfamily/3.30.250.10 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947170 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947170 HAMAP MF_00268 http://hamap.expasy.org/unirule/MF_00268 HOGENOM HOG000264120 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000264120&db=HOGENOM6 InParanoid P0A7G6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7G6 IntAct P0A7G6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7G6* InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR013765 http://www.ebi.ac.uk/interpro/entry/IPR013765 InterPro IPR020584 http://www.ebi.ac.uk/interpro/entry/IPR020584 InterPro IPR020587 http://www.ebi.ac.uk/interpro/entry/IPR020587 InterPro IPR020588 http://www.ebi.ac.uk/interpro/entry/IPR020588 InterPro IPR023400 http://www.ebi.ac.uk/interpro/entry/IPR023400 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW2669 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2669 KEGG_Gene eco:b2699 http://www.genome.jp/dbget-bin/www_bget?eco:b2699 KEGG_Orthology KO:K03553 http://www.genome.jp/dbget-bin/www_bget?KO:K03553 KEGG_Pathway ko03440 http://www.genome.jp/kegg-bin/show_pathway?ko03440 MINT MINT-1300726 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1300726 OMA PPFKEAH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PPFKEAH PANTHER PTHR22942:SF1 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22942:SF1 PDB 1AA3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1AA3 PDB 1N03 http://www.ebi.ac.uk/pdbe-srv/view/entry/1N03 PDB 1REA http://www.ebi.ac.uk/pdbe-srv/view/entry/1REA PDB 1U94 http://www.ebi.ac.uk/pdbe-srv/view/entry/1U94 PDB 1U98 http://www.ebi.ac.uk/pdbe-srv/view/entry/1U98 PDB 1U99 http://www.ebi.ac.uk/pdbe-srv/view/entry/1U99 PDB 1XMS http://www.ebi.ac.uk/pdbe-srv/view/entry/1XMS PDB 1XMV http://www.ebi.ac.uk/pdbe-srv/view/entry/1XMV PDB 2REB http://www.ebi.ac.uk/pdbe-srv/view/entry/2REB PDB 2REC http://www.ebi.ac.uk/pdbe-srv/view/entry/2REC PDB 3CMT http://www.ebi.ac.uk/pdbe-srv/view/entry/3CMT PDB 3CMU http://www.ebi.ac.uk/pdbe-srv/view/entry/3CMU PDB 3CMV http://www.ebi.ac.uk/pdbe-srv/view/entry/3CMV PDB 3CMW http://www.ebi.ac.uk/pdbe-srv/view/entry/3CMW PDB 3CMX http://www.ebi.ac.uk/pdbe-srv/view/entry/3CMX PDB 4TWZ http://www.ebi.ac.uk/pdbe-srv/view/entry/4TWZ PDBsum 1AA3 http://www.ebi.ac.uk/pdbsum/1AA3 PDBsum 1N03 http://www.ebi.ac.uk/pdbsum/1N03 PDBsum 1REA http://www.ebi.ac.uk/pdbsum/1REA PDBsum 1U94 http://www.ebi.ac.uk/pdbsum/1U94 PDBsum 1U98 http://www.ebi.ac.uk/pdbsum/1U98 PDBsum 1U99 http://www.ebi.ac.uk/pdbsum/1U99 PDBsum 1XMS http://www.ebi.ac.uk/pdbsum/1XMS PDBsum 1XMV http://www.ebi.ac.uk/pdbsum/1XMV PDBsum 2REB http://www.ebi.ac.uk/pdbsum/2REB PDBsum 2REC http://www.ebi.ac.uk/pdbsum/2REC PDBsum 3CMT http://www.ebi.ac.uk/pdbsum/3CMT PDBsum 3CMU http://www.ebi.ac.uk/pdbsum/3CMU PDBsum 3CMV http://www.ebi.ac.uk/pdbsum/3CMV PDBsum 3CMW http://www.ebi.ac.uk/pdbsum/3CMW PDBsum 3CMX http://www.ebi.ac.uk/pdbsum/3CMX PDBsum 4TWZ http://www.ebi.ac.uk/pdbsum/4TWZ PRINTS PR00142 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00142 PROSITE PS00321 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00321 PROSITE PS50162 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50162 PROSITE PS50163 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50163 PSORT swissprot:RECA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RECA_ECOLI PSORT-B swissprot:RECA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RECA_ECOLI PSORT2 swissprot:RECA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RECA_ECOLI Pfam PF00154 http://pfam.xfam.org/family/PF00154 Phobius swissprot:RECA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RECA_ECOLI PhylomeDB P0A7G6 http://phylomedb.org/?seqid=P0A7G6 ProteinModelPortal P0A7G6 http://www.proteinmodelportal.org/query/uniprot/P0A7G6 PubMed 16483938 http://www.ncbi.nlm.nih.gov/pubmed/16483938 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1731246 http://www.ncbi.nlm.nih.gov/pubmed/1731246 PubMed 1731253 http://www.ncbi.nlm.nih.gov/pubmed/1731253 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 22412352 http://www.ncbi.nlm.nih.gov/pubmed/22412352 PubMed 2274037 http://www.ncbi.nlm.nih.gov/pubmed/2274037 PubMed 26845522 http://www.ncbi.nlm.nih.gov/pubmed/26845522 PubMed 6244554 http://www.ncbi.nlm.nih.gov/pubmed/6244554 PubMed 6930655 http://www.ncbi.nlm.nih.gov/pubmed/6930655 PubMed 7588783 http://www.ncbi.nlm.nih.gov/pubmed/7588783 PubMed 7608206 http://www.ncbi.nlm.nih.gov/pubmed/7608206 PubMed 7737176 http://www.ncbi.nlm.nih.gov/pubmed/7737176 PubMed 9033586 http://www.ncbi.nlm.nih.gov/pubmed/9033586 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9230304 http://www.ncbi.nlm.nih.gov/pubmed/9230304 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417179 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417179 RefSeq WP_000963143 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000963143 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P0A7G6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7G6 STRING 511145.b2699 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2699&targetmode=cogs STRING COG0468 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0468&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SUPFAM SSF54752 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54752 SWISS-2DPAGE P0A7G6 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A7G6 TIGRFAMs TIGR02012 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02012 UniProtKB RECA_ECOLI http://www.uniprot.org/uniprot/RECA_ECOLI UniProtKB-AC P0A7G6 http://www.uniprot.org/uniprot/P0A7G6 charge swissprot:RECA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RECA_ECOLI eggNOG COG0468 http://eggnogapi.embl.de/nog_data/html/tree/COG0468 eggNOG ENOG4105C68 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C68 epestfind swissprot:RECA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RECA_ECOLI garnier swissprot:RECA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RECA_ECOLI helixturnhelix swissprot:RECA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RECA_ECOLI hmoment swissprot:RECA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RECA_ECOLI iep swissprot:RECA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RECA_ECOLI inforesidue swissprot:RECA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RECA_ECOLI octanol swissprot:RECA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RECA_ECOLI pepcoil swissprot:RECA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RECA_ECOLI pepdigest swissprot:RECA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RECA_ECOLI pepinfo swissprot:RECA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RECA_ECOLI pepnet swissprot:RECA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RECA_ECOLI pepstats swissprot:RECA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RECA_ECOLI pepwheel swissprot:RECA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RECA_ECOLI pepwindow swissprot:RECA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RECA_ECOLI sigcleave swissprot:RECA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RECA_ECOLI ## Database ID URL or Descriptions # AltName MLRA_ECOLI MerR-like regulator A # BioGrid 4260445 15 # EcoGene EG12008 mlrA # FUNCTION MLRA_ECOLI Transcriptional activator of the csg genes required for production of the curli (AgF). {ECO 0000269|PubMed 11489123}. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # INTERACTION MLRA_ECOLI P77334 gmr; NbExp=2; IntAct=EBI-1127668, EBI-548149; P77302 ydaM; NbExp=2; IntAct=EBI-1127668, EBI-544662; # IntAct P33358 8 # InterPro IPR000551 MerR-type_HTH_dom # InterPro IPR009061 DNA-bd_dom_put # Organism MLRA_ECOLI Escherichia coli (strain K12) # PATRIC 32119591 VBIEscCol129921_2206 # PIR F64980 F64980 # PROSITE PS00552 HTH_MERR_1 # PROSITE PS50937 HTH_MERR_2 # Pfam PF13411 MerR_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MLRA_ECOLI HTH-type transcriptional regulator MlrA # RefSeq NP_416631 NC_000913.3 # RefSeq WP_001240401 NZ_LN832404.1 # SIMILARITY Contains 1 HTH merR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00254}. # SMART SM00422 HTH_MERR # SUPFAM SSF46955 SSF46955 # eggNOG COG0789 LUCA # eggNOG ENOG4108XDN Bacteria BLAST swissprot:MLRA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MLRA_ECOLI BioCyc ECOL316407:JW2115-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2115-MONOMER BioCyc EcoCyc:EG12008-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12008-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2001.02529.x http://dx.doi.org/10.1046/j.1365-2958.2001.02529.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AF288173 http://www.ebi.ac.uk/ena/data/view/AF288173 EMBL AF288174 http://www.ebi.ac.uk/ena/data/view/AF288174 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1946 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1946 EcoGene EG12008 http://www.ecogene.org/geneInfo.php?eg_id=EG12008 EnsemblBacteria AAC75188 http://www.ensemblgenomes.org/id/AAC75188 EnsemblBacteria AAC75188 http://www.ensemblgenomes.org/id/AAC75188 EnsemblBacteria BAE76603 http://www.ensemblgenomes.org/id/BAE76603 EnsemblBacteria BAE76603 http://www.ensemblgenomes.org/id/BAE76603 EnsemblBacteria BAE76603 http://www.ensemblgenomes.org/id/BAE76603 EnsemblBacteria b2127 http://www.ensemblgenomes.org/id/b2127 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 949029 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949029 HOGENOM HOG000119656 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000119656&db=HOGENOM6 InParanoid P33358 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33358 IntAct P33358 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33358* InterPro IPR000551 http://www.ebi.ac.uk/interpro/entry/IPR000551 InterPro IPR009061 http://www.ebi.ac.uk/interpro/entry/IPR009061 KEGG_Gene ecj:JW2115 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2115 KEGG_Gene eco:b2127 http://www.genome.jp/dbget-bin/www_bget?eco:b2127 OMA WLEAWIA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WLEAWIA PROSITE PS00552 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00552 PROSITE PS50937 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50937 PSORT swissprot:MLRA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MLRA_ECOLI PSORT-B swissprot:MLRA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MLRA_ECOLI PSORT2 swissprot:MLRA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MLRA_ECOLI Pfam PF13411 http://pfam.xfam.org/family/PF13411 Phobius swissprot:MLRA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MLRA_ECOLI ProteinModelPortal P33358 http://www.proteinmodelportal.org/query/uniprot/P33358 PubMed 11489123 http://www.ncbi.nlm.nih.gov/pubmed/11489123 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416631 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416631 RefSeq WP_001240401 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001240401 SMART SM00422 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00422 SMR P33358 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33358 STRING 511145.b2127 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2127&targetmode=cogs SUPFAM SSF46955 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46955 UniProtKB MLRA_ECOLI http://www.uniprot.org/uniprot/MLRA_ECOLI UniProtKB-AC P33358 http://www.uniprot.org/uniprot/P33358 charge swissprot:MLRA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MLRA_ECOLI eggNOG COG0789 http://eggnogapi.embl.de/nog_data/html/tree/COG0789 eggNOG ENOG4108XDN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108XDN epestfind swissprot:MLRA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MLRA_ECOLI garnier swissprot:MLRA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MLRA_ECOLI helixturnhelix swissprot:MLRA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MLRA_ECOLI hmoment swissprot:MLRA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MLRA_ECOLI iep swissprot:MLRA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MLRA_ECOLI inforesidue swissprot:MLRA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MLRA_ECOLI octanol swissprot:MLRA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MLRA_ECOLI pepcoil swissprot:MLRA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MLRA_ECOLI pepdigest swissprot:MLRA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MLRA_ECOLI pepinfo swissprot:MLRA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MLRA_ECOLI pepnet swissprot:MLRA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MLRA_ECOLI pepstats swissprot:MLRA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MLRA_ECOLI pepwheel swissprot:MLRA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MLRA_ECOLI pepwindow swissprot:MLRA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MLRA_ECOLI sigcleave swissprot:MLRA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MLRA_ECOLI ## Database ID URL or Descriptions # BioGrid 4263246 8 # EcoGene EG11937 yjcB # IntAct P32700 4 # InterPro IPR016958 UCP030798 # Organism YJCB_ECOLI Escherichia coli (strain K12) # PATRIC 32123665 VBIEscCol129921_4181 # PIRSF PIRSF030798 UCP030798 # Pfam PF15940 YjcB # ProDom PD064934 UCP030798 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJCB_ECOLI Uncharacterized protein YjcB # RefSeq NP_418484 NC_000913.3 # RefSeq WP_001295689 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAC43154.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # eggNOG ENOG4105PMV Bacteria # eggNOG ENOG4111X06 LUCA BLAST swissprot:YJCB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJCB_ECOLI BioCyc ECOL316407:JW5718-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5718-MONOMER BioCyc EcoCyc:EG11937-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11937-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1881 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1881 EcoGene EG11937 http://www.ecogene.org/geneInfo.php?eg_id=EG11937 EnsemblBacteria AAC77030 http://www.ensemblgenomes.org/id/AAC77030 EnsemblBacteria AAC77030 http://www.ensemblgenomes.org/id/AAC77030 EnsemblBacteria BAE78062 http://www.ensemblgenomes.org/id/BAE78062 EnsemblBacteria BAE78062 http://www.ensemblgenomes.org/id/BAE78062 EnsemblBacteria BAE78062 http://www.ensemblgenomes.org/id/BAE78062 EnsemblBacteria b4060 http://www.ensemblgenomes.org/id/b4060 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 948569 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948569 HOGENOM HOG000126920 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126920&db=HOGENOM6 IntAct P32700 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32700* InterPro IPR016958 http://www.ebi.ac.uk/interpro/entry/IPR016958 KEGG_Gene ecj:JW5718 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5718 KEGG_Gene eco:b4060 http://www.genome.jp/dbget-bin/www_bget?eco:b4060 OMA SHTPPEW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SHTPPEW PSORT swissprot:YJCB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJCB_ECOLI PSORT-B swissprot:YJCB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJCB_ECOLI PSORT2 swissprot:YJCB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJCB_ECOLI Pfam PF15940 http://pfam.xfam.org/family/PF15940 Phobius swissprot:YJCB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJCB_ECOLI ProteinModelPortal P32700 http://www.proteinmodelportal.org/query/uniprot/P32700 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418484 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418484 RefSeq WP_001295689 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295689 STRING 511145.b4060 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4060&targetmode=cogs UniProtKB YJCB_ECOLI http://www.uniprot.org/uniprot/YJCB_ECOLI UniProtKB-AC P32700 http://www.uniprot.org/uniprot/P32700 charge swissprot:YJCB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJCB_ECOLI eggNOG ENOG4105PMV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105PMV eggNOG ENOG4111X06 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111X06 epestfind swissprot:YJCB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJCB_ECOLI garnier swissprot:YJCB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJCB_ECOLI helixturnhelix swissprot:YJCB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJCB_ECOLI hmoment swissprot:YJCB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJCB_ECOLI iep swissprot:YJCB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJCB_ECOLI inforesidue swissprot:YJCB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJCB_ECOLI octanol swissprot:YJCB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJCB_ECOLI pepcoil swissprot:YJCB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJCB_ECOLI pepdigest swissprot:YJCB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJCB_ECOLI pepinfo swissprot:YJCB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJCB_ECOLI pepnet swissprot:YJCB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJCB_ECOLI pepstats swissprot:YJCB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJCB_ECOLI pepwheel swissprot:YJCB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJCB_ECOLI pepwindow swissprot:YJCB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJCB_ECOLI sigcleave swissprot:YJCB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJCB_ECOLI ## Database ID URL or Descriptions # AltName ACCC_ECOLI Acetyl-CoA carboxylase subunit A # BRENDA 6.3.4.14 2026 # BioGrid 4262456 258 # CATALYTIC ACTIVITY ACCC_ECOLI ATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoA. # CATALYTIC ACTIVITY ACCC_ECOLI ATP + biotin-[carboxyl-carrier-protein] + HCO(3)(-) = ADP + phosphate + carboxy-biotin-[carboxyl-carrier- protein]. # EcoGene EG10276 accC # FUNCTION ACCC_ECOLI This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. # GO_component GO:0005737 cytoplasm; IC:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003989 acetyl-CoA carboxylase activity; IEA:UniProtKB-EC. # GO_function GO:0004075 biotin carboxylase activity; IDA:EcoliWiki. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0046872 metal ion binding; IEA:InterPro. # GO_process GO:0006633 fatty acid biosynthetic process; IMP:EcoCyc. # GO_process GO:0045717 negative regulation of fatty acid biosynthetic process; IMP:EcoliWiki. # GO_process GO:2001295 malonyl-CoA biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.30.1490.20 -; 1. # Gene3D 3.30.470.20 -; 1. # Gene3D 3.40.50.20 -; 1. # INTERACTION ACCC_ECOLI P0ABD8 accB; NbExp=6; IntAct=EBI-542308, EBI-542320; # IntAct P24182 20 # InterPro IPR004549 Acetyl_CoA_COase_biotin_COase # InterPro IPR005479 CbamoylP_synth_lsu-like_ATP-bd # InterPro IPR005481 BC-like_N # InterPro IPR005482 Biotin_COase_C # InterPro IPR011054 Rudment_hybrid_motif # InterPro IPR011761 ATP-grasp # InterPro IPR011764 Biotin_carboxylation_dom # InterPro IPR013815 ATP_grasp_subdomain_1 # InterPro IPR013816 ATP_grasp_subdomain_2 # InterPro IPR016185 PreATP-grasp_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00061 Fatty acid biosynthesis # KEGG_Pathway ko00253 Tetracycline biosynthesis # KEGG_Pathway ko00620 Pyruvate metabolism # KEGG_Pathway ko00640 Propanoate metabolism # KEGG_Pathway ko00720 Carbon fixation pathways in prokaryotes # Organism ACCC_ECOLI Escherichia coli (strain K12) # PATHWAY Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA step 1/1. # PATRIC 32121942 VBIEscCol129921_3355 # PDB 1BNC X-ray; 2.40 A; A/B=1-449 # PDB 1DV1 X-ray; 1.90 A; A/B=1-449 # PDB 1DV2 X-ray; 2.50 A; A/B=1-449 # PDB 1K69 Model; -; A=1-447 # PDB 2GPS X-ray; 2.80 A; A/B=1-449 # PDB 2GPW X-ray; 2.20 A; A/B/C/D=1-449 # PDB 2J9G X-ray; 2.05 A; A/B=1-449 # PDB 2V58 X-ray; 2.10 A; A/B=1-449 # PDB 2V59 X-ray; 2.40 A; A/B=1-449 # PDB 2V5A X-ray; 2.31 A; A/B=1-449 # PDB 2VR1 X-ray; 2.60 A; A/B=1-449 # PDB 2W6M X-ray; 2.00 A; A/B=1-449 # PDB 2W6N X-ray; 1.87 A; A/B=1-449 # PDB 2W6O X-ray; 2.50 A; A/C=1-449 # PDB 2W6P X-ray; 1.85 A; A/B=1-449 # PDB 2W6Q X-ray; 2.05 A; A/B=1-449 # PDB 2W6Z X-ray; 1.90 A; A/B=1-449 # PDB 2W70 X-ray; 1.77 A; A/B=1-449 # PDB 2W71 X-ray; 1.99 A; A/C=1-449 # PDB 3G8C X-ray; 2.00 A; A/B=1-444 # PDB 3G8D X-ray; 1.90 A; A/B=1-444 # PDB 3JZF X-ray; 2.13 A; A/B=1-449 # PDB 3JZI X-ray; 2.31 A; A/B=1-449 # PDB 3RUP X-ray; 1.99 A; A/B=1-449 # PDB 3RV3 X-ray; 1.91 A; A/B=1-449 # PDB 3RV4 X-ray; 1.98 A; A=1-449 # PDB 4HR7 X-ray; 2.50 A; A/C/E/F=1-449 # PIR JS0632 JS0632 # PROSITE PS00866 CPSASE_1 # PROSITE PS00867 CPSASE_2 # PROSITE PS50975 ATP_GRASP # PROSITE PS50979 BC # Pfam PF00289 Biotin_carb_N # Pfam PF02785 Biotin_carb_C # Pfam PF02786 CPSase_L_D2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ACCC_ECOLI Biotin carboxylase # RefSeq NP_417722 NC_000913.3 # RefSeq WP_000884639 NZ_LN832404.1 # SIMILARITY Contains 1 ATP-grasp domain. {ECO:0000255|PROSITE- ProRule PRU00409}. # SIMILARITY Contains 1 biotin carboxylation domain. {ECO 0000305}. # SMART SM00878 Biotin_carb_C # SUBUNIT ACCC_ECOLI Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2 2 complex. {ECO 0000269|PubMed 10821865, ECO 0000269|PubMed 16793549}. # SUPFAM SSF51246 SSF51246 # SUPFAM SSF52440 SSF52440 # TIGRFAMs TIGR00514 accC # UniPathway UPA00655 UER00711 # eggNOG COG0439 LUCA # eggNOG ENOG4105CER Bacteria BLAST swissprot:ACCC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ACCC_ECOLI BioCyc ECOL316407:JW3224-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3224-MONOMER BioCyc EcoCyc:BIOTIN-CARBOXYL-MONOMER http://biocyc.org/getid?id=EcoCyc:BIOTIN-CARBOXYL-MONOMER BioCyc MetaCyc:BIOTIN-CARBOXYL-MONOMER http://biocyc.org/getid?id=MetaCyc:BIOTIN-CARBOXYL-MONOMER COG COG0439 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0439 DIP DIP-9035N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9035N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1016/j.molcel.2006.04.026 http://dx.doi.org/10.1016/j.molcel.2006.04.026 DOI 10.1021/bi00200a004 http://dx.doi.org/10.1021/bi00200a004 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.88.21.9730 http://dx.doi.org/10.1073/pnas.88.21.9730 DOI 10.1074/jbc.275.21.16183 http://dx.doi.org/10.1074/jbc.275.21.16183 DOI 10.1089/dna.1989.8.779 http://dx.doi.org/10.1089/dna.1989.8.779 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.3.4.14 http://www.genome.jp/dbget-bin/www_bget?EC:6.3.4.14 EC_number EC:6.4.1.2 http://www.genome.jp/dbget-bin/www_bget?EC:6.4.1.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M32214 http://www.ebi.ac.uk/ena/data/view/M32214 EMBL M79446 http://www.ebi.ac.uk/ena/data/view/M79446 EMBL M80458 http://www.ebi.ac.uk/ena/data/view/M80458 EMBL M83198 http://www.ebi.ac.uk/ena/data/view/M83198 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 6.3.4.14 http://enzyme.expasy.org/EC/6.3.4.14 ENZYME 6.4.1.2 http://enzyme.expasy.org/EC/6.4.1.2 EchoBASE EB0272 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0272 EcoGene EG10276 http://www.ecogene.org/geneInfo.php?eg_id=EG10276 EnsemblBacteria AAC76288 http://www.ensemblgenomes.org/id/AAC76288 EnsemblBacteria AAC76288 http://www.ensemblgenomes.org/id/AAC76288 EnsemblBacteria BAE77297 http://www.ensemblgenomes.org/id/BAE77297 EnsemblBacteria BAE77297 http://www.ensemblgenomes.org/id/BAE77297 EnsemblBacteria BAE77297 http://www.ensemblgenomes.org/id/BAE77297 EnsemblBacteria b3256 http://www.ensemblgenomes.org/id/b3256 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003989 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003989 GO_function GO:0004075 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004075 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006633 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006633 GO_process GO:0045717 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045717 GO_process GO:2001295 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2001295 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.30.1490.20 http://www.cathdb.info/version/latest/superfamily/3.30.1490.20 Gene3D 3.30.470.20 http://www.cathdb.info/version/latest/superfamily/3.30.470.20 Gene3D 3.40.50.20 http://www.cathdb.info/version/latest/superfamily/3.40.50.20 GeneID 947761 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947761 HOGENOM HOG000008988 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000008988&db=HOGENOM6 InParanoid P24182 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P24182 IntAct P24182 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P24182* IntEnz 6.3.4.14 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.4.14 IntEnz 6.4.1.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.4.1.2 InterPro IPR004549 http://www.ebi.ac.uk/interpro/entry/IPR004549 InterPro IPR005479 http://www.ebi.ac.uk/interpro/entry/IPR005479 InterPro IPR005481 http://www.ebi.ac.uk/interpro/entry/IPR005481 InterPro IPR005482 http://www.ebi.ac.uk/interpro/entry/IPR005482 InterPro IPR011054 http://www.ebi.ac.uk/interpro/entry/IPR011054 InterPro IPR011761 http://www.ebi.ac.uk/interpro/entry/IPR011761 InterPro IPR011764 http://www.ebi.ac.uk/interpro/entry/IPR011764 InterPro IPR013815 http://www.ebi.ac.uk/interpro/entry/IPR013815 InterPro IPR013816 http://www.ebi.ac.uk/interpro/entry/IPR013816 InterPro IPR016185 http://www.ebi.ac.uk/interpro/entry/IPR016185 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3224 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3224 KEGG_Gene eco:b3256 http://www.genome.jp/dbget-bin/www_bget?eco:b3256 KEGG_Orthology KO:K01961 http://www.genome.jp/dbget-bin/www_bget?KO:K01961 KEGG_Pathway ko00061 http://www.genome.jp/kegg-bin/show_pathway?ko00061 KEGG_Pathway ko00253 http://www.genome.jp/kegg-bin/show_pathway?ko00253 KEGG_Pathway ko00620 http://www.genome.jp/kegg-bin/show_pathway?ko00620 KEGG_Pathway ko00640 http://www.genome.jp/kegg-bin/show_pathway?ko00640 KEGG_Pathway ko00720 http://www.genome.jp/kegg-bin/show_pathway?ko00720 KEGG_Reaction rn:R00742 http://www.genome.jp/dbget-bin/www_bget?rn:R00742 KEGG_Reaction rn:R04385 http://www.genome.jp/dbget-bin/www_bget?rn:R04385 KEGG_Reaction rn:R04386 http://www.genome.jp/dbget-bin/www_bget?rn:R04386 MINT MINT-1266968 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1266968 OMA KGHAVEC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KGHAVEC PDB 1BNC http://www.ebi.ac.uk/pdbe-srv/view/entry/1BNC PDB 1DV1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1DV1 PDB 1DV2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1DV2 PDB 1K69 http://www.ebi.ac.uk/pdbe-srv/view/entry/1K69 PDB 2GPS http://www.ebi.ac.uk/pdbe-srv/view/entry/2GPS PDB 2GPW http://www.ebi.ac.uk/pdbe-srv/view/entry/2GPW PDB 2J9G http://www.ebi.ac.uk/pdbe-srv/view/entry/2J9G PDB 2V58 http://www.ebi.ac.uk/pdbe-srv/view/entry/2V58 PDB 2V59 http://www.ebi.ac.uk/pdbe-srv/view/entry/2V59 PDB 2V5A http://www.ebi.ac.uk/pdbe-srv/view/entry/2V5A PDB 2VR1 http://www.ebi.ac.uk/pdbe-srv/view/entry/2VR1 PDB 2W6M http://www.ebi.ac.uk/pdbe-srv/view/entry/2W6M PDB 2W6N http://www.ebi.ac.uk/pdbe-srv/view/entry/2W6N PDB 2W6O http://www.ebi.ac.uk/pdbe-srv/view/entry/2W6O PDB 2W6P http://www.ebi.ac.uk/pdbe-srv/view/entry/2W6P PDB 2W6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/2W6Q PDB 2W6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/2W6Z PDB 2W70 http://www.ebi.ac.uk/pdbe-srv/view/entry/2W70 PDB 2W71 http://www.ebi.ac.uk/pdbe-srv/view/entry/2W71 PDB 3G8C http://www.ebi.ac.uk/pdbe-srv/view/entry/3G8C PDB 3G8D http://www.ebi.ac.uk/pdbe-srv/view/entry/3G8D PDB 3JZF http://www.ebi.ac.uk/pdbe-srv/view/entry/3JZF PDB 3JZI http://www.ebi.ac.uk/pdbe-srv/view/entry/3JZI PDB 3RUP http://www.ebi.ac.uk/pdbe-srv/view/entry/3RUP PDB 3RV3 http://www.ebi.ac.uk/pdbe-srv/view/entry/3RV3 PDB 3RV4 http://www.ebi.ac.uk/pdbe-srv/view/entry/3RV4 PDB 4HR7 http://www.ebi.ac.uk/pdbe-srv/view/entry/4HR7 PDBsum 1BNC http://www.ebi.ac.uk/pdbsum/1BNC PDBsum 1DV1 http://www.ebi.ac.uk/pdbsum/1DV1 PDBsum 1DV2 http://www.ebi.ac.uk/pdbsum/1DV2 PDBsum 1K69 http://www.ebi.ac.uk/pdbsum/1K69 PDBsum 2GPS http://www.ebi.ac.uk/pdbsum/2GPS PDBsum 2GPW http://www.ebi.ac.uk/pdbsum/2GPW PDBsum 2J9G http://www.ebi.ac.uk/pdbsum/2J9G PDBsum 2V58 http://www.ebi.ac.uk/pdbsum/2V58 PDBsum 2V59 http://www.ebi.ac.uk/pdbsum/2V59 PDBsum 2V5A http://www.ebi.ac.uk/pdbsum/2V5A PDBsum 2VR1 http://www.ebi.ac.uk/pdbsum/2VR1 PDBsum 2W6M http://www.ebi.ac.uk/pdbsum/2W6M PDBsum 2W6N http://www.ebi.ac.uk/pdbsum/2W6N PDBsum 2W6O http://www.ebi.ac.uk/pdbsum/2W6O PDBsum 2W6P http://www.ebi.ac.uk/pdbsum/2W6P PDBsum 2W6Q http://www.ebi.ac.uk/pdbsum/2W6Q PDBsum 2W6Z http://www.ebi.ac.uk/pdbsum/2W6Z PDBsum 2W70 http://www.ebi.ac.uk/pdbsum/2W70 PDBsum 2W71 http://www.ebi.ac.uk/pdbsum/2W71 PDBsum 3G8C http://www.ebi.ac.uk/pdbsum/3G8C PDBsum 3G8D http://www.ebi.ac.uk/pdbsum/3G8D PDBsum 3JZF http://www.ebi.ac.uk/pdbsum/3JZF PDBsum 3JZI http://www.ebi.ac.uk/pdbsum/3JZI PDBsum 3RUP http://www.ebi.ac.uk/pdbsum/3RUP PDBsum 3RV3 http://www.ebi.ac.uk/pdbsum/3RV3 PDBsum 3RV4 http://www.ebi.ac.uk/pdbsum/3RV4 PDBsum 4HR7 http://www.ebi.ac.uk/pdbsum/4HR7 PROSITE PS00866 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00866 PROSITE PS00867 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00867 PROSITE PS50975 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50975 PROSITE PS50979 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50979 PSORT swissprot:ACCC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ACCC_ECOLI PSORT-B swissprot:ACCC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ACCC_ECOLI PSORT2 swissprot:ACCC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ACCC_ECOLI Pfam PF00289 http://pfam.xfam.org/family/PF00289 Pfam PF02785 http://pfam.xfam.org/family/PF02785 Pfam PF02786 http://pfam.xfam.org/family/PF02786 Phobius swissprot:ACCC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ACCC_ECOLI PhylomeDB P24182 http://phylomedb.org/?seqid=P24182 ProteinModelPortal P24182 http://www.proteinmodelportal.org/query/uniprot/P24182 PubMed 10821865 http://www.ncbi.nlm.nih.gov/pubmed/10821865 PubMed 1370469 http://www.ncbi.nlm.nih.gov/pubmed/1370469 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16793549 http://www.ncbi.nlm.nih.gov/pubmed/16793549 PubMed 1682920 http://www.ncbi.nlm.nih.gov/pubmed/1682920 PubMed 2575489 http://www.ncbi.nlm.nih.gov/pubmed/2575489 PubMed 7915138 http://www.ncbi.nlm.nih.gov/pubmed/7915138 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_417722 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417722 RefSeq WP_000884639 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000884639 SMART SM00878 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00878 SMR P24182 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P24182 STRING 511145.b3256 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3256&targetmode=cogs STRING COG0439 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0439&targetmode=cogs SUPFAM SSF51246 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51246 SUPFAM SSF52440 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52440 TIGRFAMs TIGR00514 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00514 UniProtKB ACCC_ECOLI http://www.uniprot.org/uniprot/ACCC_ECOLI UniProtKB-AC P24182 http://www.uniprot.org/uniprot/P24182 charge swissprot:ACCC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ACCC_ECOLI eggNOG COG0439 http://eggnogapi.embl.de/nog_data/html/tree/COG0439 eggNOG ENOG4105CER http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CER epestfind swissprot:ACCC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ACCC_ECOLI garnier swissprot:ACCC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ACCC_ECOLI helixturnhelix swissprot:ACCC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ACCC_ECOLI hmoment swissprot:ACCC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ACCC_ECOLI iep swissprot:ACCC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ACCC_ECOLI inforesidue swissprot:ACCC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ACCC_ECOLI octanol swissprot:ACCC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ACCC_ECOLI pepcoil swissprot:ACCC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ACCC_ECOLI pepdigest swissprot:ACCC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ACCC_ECOLI pepinfo swissprot:ACCC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ACCC_ECOLI pepnet swissprot:ACCC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ACCC_ECOLI pepstats swissprot:ACCC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ACCC_ECOLI pepwheel swissprot:ACCC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ACCC_ECOLI pepwindow swissprot:ACCC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ACCC_ECOLI sigcleave swissprot:ACCC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ACCC_ECOLI ## Database ID URL or Descriptions # BioGrid 4262447 214 # EcoGene EG12823 aaeA # FUNCTION AAEA_ECOLI Forms an efflux pump with AaeB. {ECO 0000255|HAMAP- Rule MF_01544, ECO 0000269|PubMed 15489430}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015238 drug transmembrane transporter activity; IBA:GO_Central. # GO_process GO:0006810 transport; IGI:EcoliWiki. # GO_process GO:0046942 carboxylic acid transport; IGI:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # Gene3D 1.25.40.10 -; 1. # HAMAP MF_01544 AaeA # INDUCTION AAEA_ECOLI Positively coregulated with aaeB and aaeX by AaeR. {ECO 0000255|HAMAP-Rule MF_01544, ECO 0000269|PubMed 15489430}. # IntAct P46482 2 # InterPro IPR006143 RND_pump_MFP # InterPro IPR011990 TPR-like_helical_dom # InterPro IPR022871 PHBA_efflux_pump_AaeA # KEGG_Brite ko02000 Transporters # Organism AAEA_ECOLI Escherichia coli (strain K12) # PATRIC 32121908 VBIEscCol129921_3338 # PIR C65116 C65116 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName p-hydroxybenzoic acid efflux pump subunit AaeA {ECO:0000255|HAMAP-Rule MF_01544} # RefSeq NP_417708 NC_000913.3 # RefSeq WP_000854021 NZ_LN832404.1 # SIMILARITY Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. {ECO:0000255|HAMAP-Rule MF_01544}. # SUBCELLULAR LOCATION AAEA_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01544}; Single-pass membrane protein {ECO 0000255|HAMAP- Rule MF_01544}. # TCDB 8.A.1.7 the membrane fusion protein (mfp) family # TIGRFAMs TIGR01730 RND_mfp # eggNOG COG1566 LUCA # eggNOG ENOG4105Y49 Bacteria BLAST swissprot:AAEA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AAEA_ECOLI BioCyc ECOL316407:JW3210-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3210-MONOMER BioCyc EcoCyc:G7686-MONOMER http://biocyc.org/getid?id=EcoCyc:G7686-MONOMER BioCyc MetaCyc:G7686-MONOMER http://biocyc.org/getid?id=MetaCyc:G7686-MONOMER COG COG1566 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1566 DIP DIP-12289N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12289N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.186.21.7196-7204.2004 http://dx.doi.org/10.1128/JB.186.21.7196-7204.2004 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2674 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2674 EcoGene EG12823 http://www.ecogene.org/geneInfo.php?eg_id=EG12823 EnsemblBacteria AAC76273 http://www.ensemblgenomes.org/id/AAC76273 EnsemblBacteria AAC76273 http://www.ensemblgenomes.org/id/AAC76273 EnsemblBacteria BAE77284 http://www.ensemblgenomes.org/id/BAE77284 EnsemblBacteria BAE77284 http://www.ensemblgenomes.org/id/BAE77284 EnsemblBacteria BAE77284 http://www.ensemblgenomes.org/id/BAE77284 EnsemblBacteria b3241 http://www.ensemblgenomes.org/id/b3241 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015238 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015238 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GO_process GO:0046942 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046942 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 1.25.40.10 http://www.cathdb.info/version/latest/superfamily/1.25.40.10 GeneID 947748 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947748 HAMAP MF_01544 http://hamap.expasy.org/unirule/MF_01544 HOGENOM HOG000112073 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000112073&db=HOGENOM6 InParanoid P46482 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P46482 IntAct P46482 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P46482* InterPro IPR006143 http://www.ebi.ac.uk/interpro/entry/IPR006143 InterPro IPR011990 http://www.ebi.ac.uk/interpro/entry/IPR011990 InterPro IPR022871 http://www.ebi.ac.uk/interpro/entry/IPR022871 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3210 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3210 KEGG_Gene eco:b3241 http://www.genome.jp/dbget-bin/www_bget?eco:b3241 KEGG_Orthology KO:K15548 http://www.genome.jp/dbget-bin/www_bget?KO:K15548 MINT MINT-1252694 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1252694 OMA RRENKRN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RRENKRN PSORT swissprot:AAEA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AAEA_ECOLI PSORT-B swissprot:AAEA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AAEA_ECOLI PSORT2 swissprot:AAEA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AAEA_ECOLI Phobius swissprot:AAEA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AAEA_ECOLI PhylomeDB P46482 http://phylomedb.org/?seqid=P46482 ProteinModelPortal P46482 http://www.proteinmodelportal.org/query/uniprot/P46482 PubMed 15489430 http://www.ncbi.nlm.nih.gov/pubmed/15489430 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417708 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417708 RefSeq WP_000854021 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000854021 SMR P46482 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P46482 STRING 511145.b3241 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3241&targetmode=cogs STRING COG1566 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1566&targetmode=cogs TCDB 8.A.1.7 http://www.tcdb.org/search/result.php?tc=8.A.1.7 TIGRFAMs TIGR01730 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01730 UniProtKB AAEA_ECOLI http://www.uniprot.org/uniprot/AAEA_ECOLI UniProtKB-AC P46482 http://www.uniprot.org/uniprot/P46482 charge swissprot:AAEA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AAEA_ECOLI eggNOG COG1566 http://eggnogapi.embl.de/nog_data/html/tree/COG1566 eggNOG ENOG4105Y49 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105Y49 epestfind swissprot:AAEA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AAEA_ECOLI garnier swissprot:AAEA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AAEA_ECOLI helixturnhelix swissprot:AAEA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AAEA_ECOLI hmoment swissprot:AAEA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AAEA_ECOLI iep swissprot:AAEA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AAEA_ECOLI inforesidue swissprot:AAEA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AAEA_ECOLI octanol swissprot:AAEA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AAEA_ECOLI pepcoil swissprot:AAEA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AAEA_ECOLI pepdigest swissprot:AAEA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AAEA_ECOLI pepinfo swissprot:AAEA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AAEA_ECOLI pepnet swissprot:AAEA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AAEA_ECOLI pepstats swissprot:AAEA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AAEA_ECOLI pepwheel swissprot:AAEA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AAEA_ECOLI pepwindow swissprot:AAEA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AAEA_ECOLI sigcleave swissprot:AAEA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AAEA_ECOLI ## Database ID URL or Descriptions # AltName REPL1_ECOLI RepA1 leader peptide # GO_process GO:0006260 DNA replication; IEA:UniProtKB-KW. # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0009058 biosynthetic process # InterPro IPR012605 RepA1_leader_peptide_Tap # Organism REPL1_ECOLI Escherichia coli (strain K12) # Pfam PF08048 RepA1_leader # RecName REPL1_ECOLI Positive regulator of RepFIC repA1 expression # RefSeq NP_061386 NC_002483.1 # RefSeq WP_001442103 NZ_CP014273.1 # TIGRFAMs TIGR03475 tap_IncFII_lead BLAST swissprot:REPL1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:REPL1_ECOLI EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 1263553 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263553 InterPro IPR012605 http://www.ebi.ac.uk/interpro/entry/IPR012605 PSORT swissprot:REPL1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:REPL1_ECOLI PSORT-B swissprot:REPL1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:REPL1_ECOLI PSORT2 swissprot:REPL1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:REPL1_ECOLI Pfam PF08048 http://pfam.xfam.org/family/PF08048 Phobius swissprot:REPL1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:REPL1_ECOLI RefSeq NP_061386 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061386 RefSeq WP_001442103 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001442103 TIGRFAMs TIGR03475 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03475 UniProtKB REPL1_ECOLI http://www.uniprot.org/uniprot/REPL1_ECOLI UniProtKB-AC P56980 http://www.uniprot.org/uniprot/P56980 charge swissprot:REPL1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:REPL1_ECOLI epestfind swissprot:REPL1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:REPL1_ECOLI garnier swissprot:REPL1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:REPL1_ECOLI helixturnhelix swissprot:REPL1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:REPL1_ECOLI hmoment swissprot:REPL1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:REPL1_ECOLI iep swissprot:REPL1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:REPL1_ECOLI inforesidue swissprot:REPL1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:REPL1_ECOLI octanol swissprot:REPL1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:REPL1_ECOLI pepcoil swissprot:REPL1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:REPL1_ECOLI pepdigest swissprot:REPL1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:REPL1_ECOLI pepinfo swissprot:REPL1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:REPL1_ECOLI pepnet swissprot:REPL1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:REPL1_ECOLI pepstats swissprot:REPL1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:REPL1_ECOLI pepwheel swissprot:REPL1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:REPL1_ECOLI pepwindow swissprot:REPL1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:REPL1_ECOLI sigcleave swissprot:REPL1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:REPL1_ECOLI ## Database ID URL or Descriptions # BioGrid 4260868 6 # CATALYTIC ACTIVITY ATP + H(2)O + monosaccharide(Out) = ADP + phosphate + monosaccharide(In). {ECO:0000255|HAMAP-Rule MF_01717}. # EcoGene EG10592 mglA # FUNCTION MGLA_ECOLI Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import. Responsible for energy coupling to the transport system (Probable). {ECO 0000305|PubMed 4910389, ECO 0000305|PubMed 6294056, ECO 0000305|PubMed 6807987}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IEA:UniProtKB-HAMAP. # GO_function GO:0005354 galactose transmembrane transporter activity; IMP:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0015407 monosaccharide-transporting ATPase activity; IEA:UniProtKB-EC. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0015757 galactose transport; IMP:EcoCyc. # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # GOslim_process GO:0006950 response to stress # Gene3D 3.40.50.300 -; 2. # IntAct P0AAG8 13 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR015862 ABC_transpr_MglA # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00214 Methyl-galactoside transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism MGLA_ECOLI Escherichia coli (strain K12) # PATRIC 32119643 VBIEscCol129921_2232 # PIR D64983 D64983 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2; 2 # PROSITE PS51260 MGLA # Pfam PF00005 ABC_tran; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Galactose/methyl galactoside import ATP-binding protein MglA {ECO:0000255|HAMAP-Rule MF_01717} # RefSeq NP_416654 NC_000913.3 # RefSeq WP_000255039 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. Galactose/methyl galactoside importer (TC 3.A.1.2.3) family. {ECO:0000255|HAMAP-Rule MF_01717}. # SIMILARITY Contains 2 ABC transporter domains. {ECO:0000255|HAMAP-Rule MF_01717}. # SMART SM00382 AAA; 2 # SUBCELLULAR LOCATION MGLA_ECOLI Cell inner membrane {ECO 0000305|PubMed 6294056}; Peripheral membrane protein {ECO 0000305|PubMed 6294056}. # SUBUNIT The complex is composed of two ATP-binding proteins (MglA), two transmembrane proteins (MglC) and a solute-binding protein (MglB). {ECO:0000255|HAMAP-Rule MF_01717}. # SUPFAM SSF52540 SSF52540; 2 # TCDB 3.A.1.2 the atp-binding cassette (abc) superfamily # eggNOG COG1129 LUCA # eggNOG ENOG4105C2J Bacteria BLAST swissprot:MGLA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MGLA_ECOLI BioCyc ECOL316407:JW2136-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2136-MONOMER BioCyc EcoCyc:MGLA-MONOMER http://biocyc.org/getid?id=EcoCyc:MGLA-MONOMER BioCyc MetaCyc:MGLA-MONOMER http://biocyc.org/getid?id=MetaCyc:MGLA-MONOMER COG COG1129 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1129 DOI 10.1007/BF00267469 http://dx.doi.org/10.1007/BF00267469 DOI 10.1007/BF00330450 http://dx.doi.org/10.1007/BF00330450 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1432-1033.1970.tb00956.x http://dx.doi.org/10.1111/j.1432-1033.1970.tb00956.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.3.17 {ECO:0000255|HAMAP-Rule:MF_01717} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.17 {ECO:0000255|HAMAP-Rule:MF_01717} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M59444 http://www.ebi.ac.uk/ena/data/view/M59444 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X05646 http://www.ebi.ac.uk/ena/data/view/X05646 ENZYME 3.6.3.17 {ECO:0000255|HAMAP-Rule:MF_01717} http://enzyme.expasy.org/EC/3.6.3.17 {ECO:0000255|HAMAP-Rule:MF_01717} EchoBASE EB0587 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0587 EcoGene EG10592 http://www.ecogene.org/geneInfo.php?eg_id=EG10592 EnsemblBacteria AAC75210 http://www.ensemblgenomes.org/id/AAC75210 EnsemblBacteria AAC75210 http://www.ensemblgenomes.org/id/AAC75210 EnsemblBacteria BAE76626 http://www.ensemblgenomes.org/id/BAE76626 EnsemblBacteria BAE76626 http://www.ensemblgenomes.org/id/BAE76626 EnsemblBacteria BAE76626 http://www.ensemblgenomes.org/id/BAE76626 EnsemblBacteria b2149 http://www.ensemblgenomes.org/id/b2149 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0005354 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005354 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0015407 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015407 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0015757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015757 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 949036 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949036 InParanoid P0AAG8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAG8 IntAct P0AAG8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAG8* IntEnz 3.6.3.17 {ECO:0000255|HAMAP-Rule:MF_01717} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.17 {ECO:0000255|HAMAP-Rule:MF_01717} InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR015862 http://www.ebi.ac.uk/interpro/entry/IPR015862 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2136 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2136 KEGG_Gene eco:b2149 http://www.genome.jp/dbget-bin/www_bget?eco:b2149 KEGG_Orthology KO:K10542 http://www.genome.jp/dbget-bin/www_bget?KO:K10542 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA KWVIDSM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KWVIDSM PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PROSITE PS51260 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51260 PSORT swissprot:MGLA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MGLA_ECOLI PSORT-B swissprot:MGLA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MGLA_ECOLI PSORT2 swissprot:MGLA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MGLA_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Phobius swissprot:MGLA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MGLA_ECOLI PhylomeDB P0AAG8 http://phylomedb.org/?seqid=P0AAG8 ProteinModelPortal P0AAG8 http://www.proteinmodelportal.org/query/uniprot/P0AAG8 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1719366 http://www.ncbi.nlm.nih.gov/pubmed/1719366 PubMed 3302609 http://www.ncbi.nlm.nih.gov/pubmed/3302609 PubMed 4910389 http://www.ncbi.nlm.nih.gov/pubmed/4910389 PubMed 6294056 http://www.ncbi.nlm.nih.gov/pubmed/6294056 PubMed 6807987 http://www.ncbi.nlm.nih.gov/pubmed/6807987 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416654 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416654 RefSeq WP_000255039 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000255039 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 STRING 511145.b2149 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2149&targetmode=cogs STRING COG1129 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1129&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.2 http://www.tcdb.org/search/result.php?tc=3.A.1.2 UniProtKB MGLA_ECOLI http://www.uniprot.org/uniprot/MGLA_ECOLI UniProtKB-AC P0AAG8 http://www.uniprot.org/uniprot/P0AAG8 charge swissprot:MGLA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MGLA_ECOLI eggNOG COG1129 http://eggnogapi.embl.de/nog_data/html/tree/COG1129 eggNOG ENOG4105C2J http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C2J epestfind swissprot:MGLA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MGLA_ECOLI garnier swissprot:MGLA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MGLA_ECOLI helixturnhelix swissprot:MGLA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MGLA_ECOLI hmoment swissprot:MGLA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MGLA_ECOLI iep swissprot:MGLA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MGLA_ECOLI inforesidue swissprot:MGLA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MGLA_ECOLI octanol swissprot:MGLA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MGLA_ECOLI pepcoil swissprot:MGLA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MGLA_ECOLI pepdigest swissprot:MGLA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MGLA_ECOLI pepinfo swissprot:MGLA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MGLA_ECOLI pepnet swissprot:MGLA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MGLA_ECOLI pepstats swissprot:MGLA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MGLA_ECOLI pepwheel swissprot:MGLA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MGLA_ECOLI pepwindow swissprot:MGLA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MGLA_ECOLI sigcleave swissprot:MGLA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MGLA_ECOLI ## Database ID URL or Descriptions # AltName CDSA_ECOLI CDP-DAG synthase # AltName CDSA_ECOLI CDP-DG synthase # AltName CDSA_ECOLI CDP-diacylglycerol synthase # AltName CDSA_ECOLI CDP-diglyceride pyrophosphorylase # AltName CDSA_ECOLI CDP-diglyceride synthase # AltName CTP phosphatidate cytidylyltransferase # CATALYTIC ACTIVITY CDSA_ECOLI CTP + phosphatidate = diphosphate + CDP- diacylglycerol. # EcoGene EG10139 cdsA # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0004605 phosphatidate cytidylyltransferase activity; IDA:EcoCyc. # GO_process GO:0006655 phosphatidylglycerol biosynthetic process; IBA:GO_Central. # GO_process GO:0016024 CDP-diacylglycerol biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # InterPro IPR000374 PC_trans # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00564 Glycerophospholipid metabolism # KEGG_Pathway ko04070 Phosphatidylinositol signaling system # Organism CDSA_ECOLI Escherichia coli (strain K12) # PATHWAY Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate step 3/3. # PATRIC 32115461 VBIEscCol129921_0182 # PIR A23898 SYECDG # PROSITE PS01315 CDS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CDSA_ECOLI Phosphatidate cytidylyltransferase # RefSeq NP_414717 NC_000913.3 # RefSeq WP_000922446 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA23545.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAB08604.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the CDS family. {ECO 0000305}. # SUBCELLULAR LOCATION CDSA_ECOLI Cell inner membrane; Multi-pass membrane protein. # UniPathway UPA00557 UER00614 # eggNOG COG0575 LUCA # eggNOG ENOG4105KNE Bacteria BLAST swissprot:CDSA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CDSA_ECOLI BioCyc ECOL316407:JW5810-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5810-MONOMER BioCyc EcoCyc:CDPDIGLYSYN-MONOMER http://biocyc.org/getid?id=EcoCyc:CDPDIGLYSYN-MONOMER BioCyc MetaCyc:CDPDIGLYSYN-MONOMER http://biocyc.org/getid?id=MetaCyc:CDPDIGLYSYN-MONOMER COG COG0575 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0575 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.7.41 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.41 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M11330 http://www.ebi.ac.uk/ena/data/view/M11330 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 ENZYME 2.7.7.41 http://enzyme.expasy.org/EC/2.7.7.41 EchoBASE EB0137 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0137 EcoGene EG10139 http://www.ecogene.org/geneInfo.php?eg_id=EG10139 EnsemblBacteria AAC73286 http://www.ensemblgenomes.org/id/AAC73286 EnsemblBacteria AAC73286 http://www.ensemblgenomes.org/id/AAC73286 EnsemblBacteria BAA77850 http://www.ensemblgenomes.org/id/BAA77850 EnsemblBacteria BAA77850 http://www.ensemblgenomes.org/id/BAA77850 EnsemblBacteria BAA77850 http://www.ensemblgenomes.org/id/BAA77850 EnsemblBacteria b0175 http://www.ensemblgenomes.org/id/b0175 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0004605 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004605 GO_process GO:0006655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006655 GO_process GO:0016024 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016024 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 944876 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944876 HOGENOM HOG000006168 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006168&db=HOGENOM6 InParanoid P0ABG1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABG1 IntEnz 2.7.7.41 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.41 InterPro IPR000374 http://www.ebi.ac.uk/interpro/entry/IPR000374 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5810 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5810 KEGG_Gene eco:b0175 http://www.genome.jp/dbget-bin/www_bget?eco:b0175 KEGG_Orthology KO:K00981 http://www.genome.jp/dbget-bin/www_bget?KO:K00981 KEGG_Pathway ko00564 http://www.genome.jp/kegg-bin/show_pathway?ko00564 KEGG_Pathway ko04070 http://www.genome.jp/kegg-bin/show_pathway?ko04070 KEGG_Reaction rn:R01799 http://www.genome.jp/dbget-bin/www_bget?rn:R01799 OMA YVFILVW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YVFILVW PROSITE PS01315 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01315 PSORT swissprot:CDSA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CDSA_ECOLI PSORT-B swissprot:CDSA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CDSA_ECOLI PSORT2 swissprot:CDSA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CDSA_ECOLI Phobius swissprot:CDSA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CDSA_ECOLI PhylomeDB P0ABG1 http://phylomedb.org/?seqid=P0ABG1 ProteinModelPortal P0ABG1 http://www.proteinmodelportal.org/query/uniprot/P0ABG1 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2995358 http://www.ncbi.nlm.nih.gov/pubmed/2995358 PubMed 2995359 http://www.ncbi.nlm.nih.gov/pubmed/2995359 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414717 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414717 RefSeq WP_000922446 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000922446 STRING 511145.b0175 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0175&targetmode=cogs STRING COG0575 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0575&targetmode=cogs UniProtKB CDSA_ECOLI http://www.uniprot.org/uniprot/CDSA_ECOLI UniProtKB-AC P0ABG1 http://www.uniprot.org/uniprot/P0ABG1 charge swissprot:CDSA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CDSA_ECOLI eggNOG COG0575 http://eggnogapi.embl.de/nog_data/html/tree/COG0575 eggNOG ENOG4105KNE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KNE epestfind swissprot:CDSA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CDSA_ECOLI garnier swissprot:CDSA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CDSA_ECOLI helixturnhelix swissprot:CDSA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CDSA_ECOLI hmoment swissprot:CDSA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CDSA_ECOLI iep swissprot:CDSA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CDSA_ECOLI inforesidue swissprot:CDSA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CDSA_ECOLI octanol swissprot:CDSA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CDSA_ECOLI pepcoil swissprot:CDSA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CDSA_ECOLI pepdigest swissprot:CDSA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CDSA_ECOLI pepinfo swissprot:CDSA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CDSA_ECOLI pepnet swissprot:CDSA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CDSA_ECOLI pepstats swissprot:CDSA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CDSA_ECOLI pepwheel swissprot:CDSA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CDSA_ECOLI pepwindow swissprot:CDSA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CDSA_ECOLI sigcleave swissprot:CDSA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CDSA_ECOLI ## Database ID URL or Descriptions # BRENDA 6.5.1 2026 # BioGrid 4261188 7 # COFACTOR RTCB_ECOLI Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 21757685, ECO 0000269|PubMed 22045815}; Note=Binds 2 manganese ions per subunit. {ECO 0000269|PubMed 21757685, ECO 0000269|PubMed 22045815}; # EcoGene EG12939 rtcB # FUNCTION RTCB_ECOLI RNA ligase that mediates the joining of broken tRNA-like stem-loop structures in case of tRNA damage. Probably participates to tRNA restriction-repair by ligating broken tRNA-like stem-loop structures with 2',3'-cyclic phosphate and 5'-OH ends to form a splice junction with a 2'-OH, 3',5'-phosphodiester, a step that requires GTP (PubMed 21224389, PubMed 22730297). Also acts as a DNA ligase in case of DNA damage by splicing 'dirty' DNA breaks, characterized by 3'-PO4 (or cyclic-PO4) and 5'-OH ends that cannot be sealed by classical DNA ligases (PubMed 24218597). {ECO 0000269|PubMed 21224389, ECO 0000269|PubMed 21757685, ECO 0000269|PubMed 22045815, ECO 0000269|PubMed 22474365, ECO 0000269|PubMed 22730297, ECO 0000269|PubMed 24218597}. # GO_function GO:0003909 DNA ligase activity; IDA:EcoCyc. # GO_function GO:0008452 RNA ligase activity; IDA:EcoCyc. # GO_function GO:0030145 manganese ion binding; IDA:UniProtKB. # GO_process GO:0006281 DNA repair; IDA:UniProtKB. # GO_process GO:0006396 RNA processing; IDA:UniProtKB. # GO_process GO:0006974 cellular response to DNA damage stimulus; IDA:UniProtKB. # GO_process GO:0042245 RNA repair; TAS:UniProtKB. # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # INDUCTION Expression is repressed by RtcR. {ECO:0000269|PubMed 21224389}. # IntAct P46850 20 # InterPro IPR001233 RtcB # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # MISCELLANEOUS In contrast to the vertebrate homolog, ligation does not seem to require ATP, while GTP stimulates activity. {ECO:0000305|PubMed 21224389}. # MISCELLANEOUS RTCB_ECOLI Ligation proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'- P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RtcB reacts with GTP to form a covalent RtcB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP (PubMed 22474365). Acts as a DNA ligase by attaching a GMP nucleotide to the DNA 3'-PO4 end to activate it for nucleophilic attack by the 5'-OH (PubMed 24218597). {ECO 0000305|PubMed 22474365, ECO 0000305|PubMed 24218597}. # Organism RTCB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11118 PTHR11118 # PATRIC 32122278 VBIEscCol129921_3516 # PIR H65137 H65137 # PROSITE PS01288 UPF0027 # Pfam PF01139 RtcB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RTCB_ECOLI RNA-splicing ligase RtcB # RefSeq NP_417879 NC_000913.3 # RefSeq WP_001105504 NZ_LN832404.1 # SIMILARITY Belongs to the RtcB family. {ECO 0000305}. # SUBUNIT Monomer. {ECO:0000269|PubMed 21224389}. # SUPFAM SSF103365 SSF103365 # eggNOG COG1690 LUCA # eggNOG ENOG4105E0Y Bacteria BLAST swissprot:RTCB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RTCB_ECOLI BioCyc ECOL316407:JW3384-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3384-MONOMER BioCyc EcoCyc:G7751-MONOMER http://biocyc.org/getid?id=EcoCyc:G7751-MONOMER BioCyc MetaCyc:G7751-MONOMER http://biocyc.org/getid?id=MetaCyc:G7751-MONOMER COG COG1690 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1690 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.1201207109 http://dx.doi.org/10.1073/pnas.1201207109 DOI 10.1073/pnas.1314289110 http://dx.doi.org/10.1073/pnas.1314289110 DOI 10.1074/jbc.273.39.25516 http://dx.doi.org/10.1074/jbc.273.39.25516 DOI 10.1074/jbc.C111.219022 http://dx.doi.org/10.1074/jbc.C111.219022 DOI 10.1074/jbc.C111.274597 http://dx.doi.org/10.1074/jbc.C111.274597 DOI 10.1074/jbc.M111.302133 http://dx.doi.org/10.1074/jbc.M111.302133 DOI 10.1093/nar/gks558 http://dx.doi.org/10.1093/nar/gks558 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.5.1.- http://www.genome.jp/dbget-bin/www_bget?EC:6.5.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 6.5.1.- http://enzyme.expasy.org/EC/6.5.1.- EchoBASE EB2774 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2774 EcoGene EG12939 http://www.ecogene.org/geneInfo.php?eg_id=EG12939 EnsemblBacteria AAC76446 http://www.ensemblgenomes.org/id/AAC76446 EnsemblBacteria AAC76446 http://www.ensemblgenomes.org/id/AAC76446 EnsemblBacteria BAE77871 http://www.ensemblgenomes.org/id/BAE77871 EnsemblBacteria BAE77871 http://www.ensemblgenomes.org/id/BAE77871 EnsemblBacteria BAE77871 http://www.ensemblgenomes.org/id/BAE77871 EnsemblBacteria b3421 http://www.ensemblgenomes.org/id/b3421 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003909 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003909 GO_function GO:0008452 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008452 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_process GO:0006281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006281 GO_process GO:0006396 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006396 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0042245 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042245 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 947929 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947929 HOGENOM HOG000220066 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220066&db=HOGENOM6 InParanoid P46850 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P46850 IntAct P46850 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P46850* IntEnz 6.5.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.5.1 InterPro IPR001233 http://www.ebi.ac.uk/interpro/entry/IPR001233 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW3384 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3384 KEGG_Gene eco:b3421 http://www.genome.jp/dbget-bin/www_bget?eco:b3421 KEGG_Orthology KO:K14415 http://www.genome.jp/dbget-bin/www_bget?KO:K14415 OMA YDVAHNV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YDVAHNV PANTHER PTHR11118 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11118 PROSITE PS01288 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01288 PSORT swissprot:RTCB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RTCB_ECOLI PSORT-B swissprot:RTCB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RTCB_ECOLI PSORT2 swissprot:RTCB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RTCB_ECOLI Pfam PF01139 http://pfam.xfam.org/family/PF01139 Phobius swissprot:RTCB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RTCB_ECOLI PhylomeDB P46850 http://phylomedb.org/?seqid=P46850 ProteinModelPortal P46850 http://www.proteinmodelportal.org/query/uniprot/P46850 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21224389 http://www.ncbi.nlm.nih.gov/pubmed/21224389 PubMed 21757685 http://www.ncbi.nlm.nih.gov/pubmed/21757685 PubMed 22045815 http://www.ncbi.nlm.nih.gov/pubmed/22045815 PubMed 22474365 http://www.ncbi.nlm.nih.gov/pubmed/22474365 PubMed 22730297 http://www.ncbi.nlm.nih.gov/pubmed/22730297 PubMed 24218597 http://www.ncbi.nlm.nih.gov/pubmed/24218597 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9738023 http://www.ncbi.nlm.nih.gov/pubmed/9738023 RefSeq NP_417879 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417879 RefSeq WP_001105504 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001105504 SMR P46850 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P46850 STRING 511145.b3421 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3421&targetmode=cogs STRING COG1690 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1690&targetmode=cogs SUPFAM SSF103365 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103365 SWISS-2DPAGE P46850 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P46850 UniProtKB RTCB_ECOLI http://www.uniprot.org/uniprot/RTCB_ECOLI UniProtKB-AC P46850 http://www.uniprot.org/uniprot/P46850 charge swissprot:RTCB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RTCB_ECOLI eggNOG COG1690 http://eggnogapi.embl.de/nog_data/html/tree/COG1690 eggNOG ENOG4105E0Y http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E0Y epestfind swissprot:RTCB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RTCB_ECOLI garnier swissprot:RTCB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RTCB_ECOLI helixturnhelix swissprot:RTCB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RTCB_ECOLI hmoment swissprot:RTCB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RTCB_ECOLI iep swissprot:RTCB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RTCB_ECOLI inforesidue swissprot:RTCB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RTCB_ECOLI octanol swissprot:RTCB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RTCB_ECOLI pepcoil swissprot:RTCB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RTCB_ECOLI pepdigest swissprot:RTCB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RTCB_ECOLI pepinfo swissprot:RTCB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RTCB_ECOLI pepnet swissprot:RTCB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RTCB_ECOLI pepstats swissprot:RTCB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RTCB_ECOLI pepwheel swissprot:RTCB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RTCB_ECOLI pepwindow swissprot:RTCB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RTCB_ECOLI sigcleave swissprot:RTCB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RTCB_ECOLI ## Database ID URL or Descriptions # AltName HLDD_ECOLI ADP-L-glycero-beta-D-manno-heptose-6-epimerase # BIOPHYSICOCHEMICAL PROPERTIES HLDD_ECOLI Kinetic parameters KM=0.1 mM for ADP-heptose {ECO 0000269|PubMed 7929099}; Vmax=1.53 umol/min/mg enzyme {ECO 0000269|PubMed 7929099}; pH dependence Optimum pH is 5.5-9.5. {ECO 0000269|PubMed 7929099}; Temperature dependence Optimum temperature is 42 degrees Celsius. {ECO 0000269|PubMed 7929099}; # BRENDA 5.1.3.20 2026 # BioGrid 4263293 559 # CATALYTIC ACTIVITY ADP-D-glycero-D-manno-heptose = ADP-L-glycero- D-manno-heptose. {ECO:0000269|PubMed 7929099}. # CAUTION Was originally thought to be a homohexamer. {ECO:0000305|PubMed 7929099}. # CDD cd05248 ADP_GME_SDR_e # COFACTOR HLDD_ECOLI Name=NADP(+); Xref=ChEBI CHEBI 58349; Evidence={ECO 0000269|PubMed 11313358, ECO 0000269|PubMed 7929099}; Name=NAD(+); Xref=ChEBI CHEBI 57540; Evidence={ECO 0000269|PubMed 11313358, ECO 0000269|PubMed 7929099}; Note=Binds 1 NADP(+) per subunit. NAD(+) can substitute for NADP(+), but enzymatic activity is reduced. {ECO 0000269|PubMed 11313358, ECO 0000269|PubMed 7929099}; # DOMAIN HLDD_ECOLI Contains a large N-terminal NADP-binding domain associated with a modified Rossman fold, and a smaller C-terminal substrate- binding domain. # ENZYME REGULATION HLDD_ECOLI Completely inhibited by ADP and ADP-glucose, and partially inhibited by ATP and NADH. # EcoGene EG10838 hldD # FUNCTION HLDD_ECOLI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose. {ECO 0000269|PubMed 6337148, ECO 0000269|PubMed 7929099}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0008712 ADP-glyceromanno-heptose 6-epimerase activity; IDA:EcoCyc. # GO_function GO:0070401 NADP+ binding; IDA:EcoCyc. # GO_process GO:0009244 lipopolysaccharide core region biosynthetic process; IMP:EcoCyc. # GO_process GO:0097171 ADP-L-glycero-beta-D-manno-heptose biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.50.720 -; 1. # HAMAP MF_01601 Heptose_epimerase # INDUCTION HLDD_ECOLI By heat shock. # INTERACTION HLDD_ECOLI P0ABU0 menB; NbExp=2; IntAct=EBI-543760, EBI-554195; # IntAct P67910 39 # InterPro IPR001509 Epimerase_deHydtase # InterPro IPR011912 Heptose_epim # InterPro IPR016040 NAD(P)-bd_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # KEGG_Pathway ko00540 Lipopolysaccharide biosynthesis # MISCELLANEOUS HLDD_ECOLI Essential for E.coli viability at elevated temperatures. Insertional inactivation of the gene by the Tn5 transposon results in E.coli being unable to form colonies at temperatures above 43 degrees Celsius. # Organism HLDD_ECOLI Escherichia coli (strain K12) # PATHWAY HLDD_ECOLI Bacterial outer membrane biogenesis; LPS core biosynthesis. # PATHWAY Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D- manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate step 4/4. # PATRIC 32122725 VBIEscCol129921_3739 # PDB 1EQ2 X-ray; 2.00 A; A/B/C/D/E/F/G/H/I/J=1-310 # PDB 2X6T X-ray; 2.36 A; A/B/C/D/E/F/G/H/I/J=1-310 # PIR JU0299 JU0299 # Pfam PF01370 Epimerase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HLDD_ECOLI ADP-L-glycero-D-manno-heptose-6-epimerase # RefSeq NP_418076 NC_000913.3 # RefSeq WP_000587764 NZ_LN832404.1 # SIMILARITY Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. {ECO 0000305}. # SUBUNIT HLDD_ECOLI Homopentamer. {ECO 0000269|PubMed 10896473, ECO 0000269|PubMed 7929099}. # SUPFAM SSF51735 SSF51735 # TIGRFAMs TIGR02197 heptose_epim # UniPathway UPA00356 UER00440 # eggNOG COG0451 LUCA # eggNOG ENOG4105CUI Bacteria BLAST swissprot:HLDD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HLDD_ECOLI BioCyc ECOL316407:JW3594-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3594-MONOMER BioCyc EcoCyc:EG10838-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10838-MONOMER BioCyc MetaCyc:EG10838-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10838-MONOMER COG COG0451 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0451 DIP DIP-35958N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35958N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1016/S0969-2126(00)00128-3 http://dx.doi.org/10.1016/S0969-2126(00)00128-3 DOI 10.1021/bi602641m http://dx.doi.org/10.1021/bi602641m DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M102258200 http://dx.doi.org/10.1074/jbc.M102258200 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/nar/19.14.3811 http://dx.doi.org/10.1093/nar/19.14.3811 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1107/S0907444998014723 http://dx.doi.org/10.1107/S0907444998014723 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.2.363-369.2002 http://dx.doi.org/10.1128/JB.184.2.363-369.2002 EC_number EC:5.1.3.20 {ECO:0000269|PubMed:7929099} http://www.genome.jp/dbget-bin/www_bget?EC:5.1.3.20 {ECO:0000269|PubMed:7929099} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M33577 http://www.ebi.ac.uk/ena/data/view/M33577 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X54492 http://www.ebi.ac.uk/ena/data/view/X54492 ENZYME 5.1.3.20 {ECO:0000269|PubMed:7929099} http://enzyme.expasy.org/EC/5.1.3.20 {ECO:0000269|PubMed:7929099} EchoBASE EB0831 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0831 EcoGene EG10838 http://www.ecogene.org/geneInfo.php?eg_id=EG10838 EnsemblBacteria AAC76643 http://www.ensemblgenomes.org/id/AAC76643 EnsemblBacteria AAC76643 http://www.ensemblgenomes.org/id/AAC76643 EnsemblBacteria BAE77673 http://www.ensemblgenomes.org/id/BAE77673 EnsemblBacteria BAE77673 http://www.ensemblgenomes.org/id/BAE77673 EnsemblBacteria BAE77673 http://www.ensemblgenomes.org/id/BAE77673 EnsemblBacteria b3619 http://www.ensemblgenomes.org/id/b3619 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0008712 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008712 GO_function GO:0070401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070401 GO_process GO:0009244 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009244 GO_process GO:0097171 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097171 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 948134 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948134 HAMAP MF_01601 http://hamap.expasy.org/unirule/MF_01601 HOGENOM HOG000167987 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000167987&db=HOGENOM6 InParanoid P67910 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P67910 IntAct P67910 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P67910* IntEnz 5.1.3.20 {ECO:0000269|PubMed:7929099} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.1.3.20 {ECO:0000269|PubMed:7929099} InterPro IPR001509 http://www.ebi.ac.uk/interpro/entry/IPR001509 InterPro IPR011912 http://www.ebi.ac.uk/interpro/entry/IPR011912 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Gene ecj:JW3594 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3594 KEGG_Gene eco:b3619 http://www.genome.jp/dbget-bin/www_bget?eco:b3619 KEGG_Orthology KO:K03274 http://www.genome.jp/dbget-bin/www_bget?KO:K03274 KEGG_Pathway ko00540 http://www.genome.jp/kegg-bin/show_pathway?ko00540 KEGG_Reaction rn:R05176 http://www.genome.jp/dbget-bin/www_bget?rn:R05176 OMA MENNYRY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MENNYRY PDB 1EQ2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1EQ2 PDB 2X6T http://www.ebi.ac.uk/pdbe-srv/view/entry/2X6T PDBsum 1EQ2 http://www.ebi.ac.uk/pdbsum/1EQ2 PDBsum 2X6T http://www.ebi.ac.uk/pdbsum/2X6T PSORT swissprot:HLDD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HLDD_ECOLI PSORT-B swissprot:HLDD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HLDD_ECOLI PSORT2 swissprot:HLDD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HLDD_ECOLI Pfam PF01370 http://pfam.xfam.org/family/PF01370 Phobius swissprot:HLDD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HLDD_ECOLI PhylomeDB P67910 http://phylomedb.org/?seqid=P67910 ProteinModelPortal P67910 http://www.proteinmodelportal.org/query/uniprot/P67910 PubMed 10089470 http://www.ncbi.nlm.nih.gov/pubmed/10089470 PubMed 10896473 http://www.ncbi.nlm.nih.gov/pubmed/10896473 PubMed 11313358 http://www.ncbi.nlm.nih.gov/pubmed/11313358 PubMed 11751812 http://www.ncbi.nlm.nih.gov/pubmed/11751812 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17316025 http://www.ncbi.nlm.nih.gov/pubmed/17316025 PubMed 1861974 http://www.ncbi.nlm.nih.gov/pubmed/1861974 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 2198271 http://www.ncbi.nlm.nih.gov/pubmed/2198271 PubMed 6337148 http://www.ncbi.nlm.nih.gov/pubmed/6337148 PubMed 7929099 http://www.ncbi.nlm.nih.gov/pubmed/7929099 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_418076 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418076 RefSeq WP_000587764 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000587764 SMR P67910 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P67910 STRING 511145.b3619 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3619&targetmode=cogs STRING COG0451 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0451&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 SWISS-2DPAGE P67910 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P67910 TIGRFAMs TIGR02197 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02197 UniProtKB HLDD_ECOLI http://www.uniprot.org/uniprot/HLDD_ECOLI UniProtKB-AC P67910 http://www.uniprot.org/uniprot/P67910 charge swissprot:HLDD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HLDD_ECOLI eggNOG COG0451 http://eggnogapi.embl.de/nog_data/html/tree/COG0451 eggNOG ENOG4105CUI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CUI epestfind swissprot:HLDD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HLDD_ECOLI garnier swissprot:HLDD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HLDD_ECOLI helixturnhelix swissprot:HLDD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HLDD_ECOLI hmoment swissprot:HLDD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HLDD_ECOLI iep swissprot:HLDD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HLDD_ECOLI inforesidue swissprot:HLDD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HLDD_ECOLI octanol swissprot:HLDD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HLDD_ECOLI pepcoil swissprot:HLDD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HLDD_ECOLI pepdigest swissprot:HLDD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HLDD_ECOLI pepinfo swissprot:HLDD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HLDD_ECOLI pepnet swissprot:HLDD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HLDD_ECOLI pepstats swissprot:HLDD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HLDD_ECOLI pepwheel swissprot:HLDD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HLDD_ECOLI pepwindow swissprot:HLDD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HLDD_ECOLI sigcleave swissprot:HLDD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HLDD_ECOLI ## Database ID URL or Descriptions # AltName RNA polymerase sigma-32 factor {ECO:0000255|HAMAP-Rule MF_00961} # AltName RPOH_ECOLI Heat shock regulatory protein F33.4 # BioGrid 4262497 257 # DISRUPTION PHENOTYPE Mutants exhibit an increased sensitivity to heat shock but only in the exponential phase of aerobic growth. {ECO:0000269|PubMed 16775749}. # DOMAIN RPOH_ECOLI The sigma-70 factor domain-2 mediates sequence-specific interaction with the -10 element in promoter DNA, and plays an important role in melting the double-stranded DNA and the formation of the transcription bubble. The sigma-70 factor domain- 2 mediates interaction with the RNA polymerase subunits RpoB and RpoC (By similarity). {ECO 0000250}. # DOMAIN RPOH_ECOLI The sigma-70 factor domain-4 contains a helix-turn-helix (H-T-H) motif that mediates interaction with the -35 element in promoter DNA. The domain also mediates interaction with the RNA polymerase subunit RpoA (By similarity). {ECO 0000250}. # EcoGene EG10897 rpoH # FUNCTION RPOH_ECOLI Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. Intracellular concentration of free RpoH protein increases in response to heat shock, which causes association with RNA polymerase (RNAP) and initiation of transcription of heat shock genes, including numerous global transcriptional regulators and genes involved in maintaining membrane functionality and homeostasis. RpoH is then quickly degraded, leading to a decrease in the rate of synthesis of heat shock proteins and shut-off of the heat shock response. {ECO 0000255|HAMAP-Rule MF_00961, ECO 0000269|PubMed 15757896, ECO 0000269|PubMed 16818608, ECO 0000269|PubMed 3306410, ECO 0000269|PubMed 3315848, ECO 0000269|PubMed 6387714}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_function GO:0000990 transcription factor activity, core RNA polymerase binding; IDA:CACAO. # GO_function GO:0003677 DNA binding; IDA:EcoliWiki. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_function GO:0008270 zinc ion binding; IEA:InterPro. # GO_function GO:0016987 sigma factor activity; IDA:EcoCyc. # GO_process GO:0001121 transcription from bacterial-type RNA polymerase promoter; IDA:EcoCyc. # GO_process GO:0001123 transcription initiation from bacterial-type RNA polymerase promoter; IEA:UniProtKB-HAMAP. # GO_process GO:0006351 transcription, DNA-templated; IDA:CACAO. # GO_process GO:0006355 regulation of transcription, DNA-templated; IMP:EcoliWiki. # GO_process GO:0009408 response to heat; IMP:EcoCyc. # GO_process GO:0010468 regulation of gene expression; IDA:EcoCyc. # GO_process GO:0030435 sporulation resulting in formation of a cellular spore; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0000988 transcription factor activity, protein binding # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0030154 cell differentiation # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0048646 anatomical structure formation involved in morphogenesis # Gene3D 1.10.10.10 -; 1. # HAMAP MF_00961 Sigma70_RpoH # INDUCTION RPOH_ECOLI Subject to complex regulation at multiple levels (transcription, translation, regulation of activity and degradation). In the absence of heat shock, or after heat shock, activity is inhibited by transient association with DnaK and DnaJ, which reduces the amounts of free active RpoH, makes it unstable and mediates its degradation by the FtsH protease. During heat shock, the intracellular concentration of RpoH increases, due to slightly increased transcription, increased synthesis and stabilization of the protein. Induction occurs mainly at the post- transcriptional level, via translational thermoregulation at low temperature, the structure of the rpoH mRNA blocks its translation, while at high temperature, melting of the mRNA secondary structure facilitates ribosome binding and synthesis of the RpoH protein. In addition, during heat shock, stabilization of RpoH is triggered by the titration of free DnaK/DnaJ by stress- induced misfolded proteins. Can also be induced by other stress conditions, including during the first round of cell division. {ECO 0000269|PubMed 10090722, ECO 0000269|PubMed 15757896, ECO 0000269|PubMed 19114495, ECO 0000269|PubMed 3306410, ECO 0000269|PubMed 3315848, ECO 0000269|PubMed 3315851, ECO 0000269|PubMed 8599944, ECO 0000269|PubMed 9822823, ECO 0000269|PubMed 9882652}. # INTERACTION RPOH_ECOLI P0A6Y8 dnaK; NbExp=5; IntAct=EBI-555342, EBI-542092; P0A6F5 groL; NbExp=2; IntAct=EBI-555342, EBI-543750; # IntAct P0AGB3 14 # InterPro IPR000943 RNA_pol_sigma70 # InterPro IPR007627 RNA_pol_sigma70_r2 # InterPro IPR007630 RNA_pol_sigma70_r4 # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR012759 RNA_pol_sigma_RpoH_proteobac # InterPro IPR013324 RNA_pol_sigma_r3_r4 # InterPro IPR013325 RNA_pol_sigma_r2 # InterPro IPR014284 RNA_pol_sigma-70_dom # InterPro IPR016263 RNA_pol_sigma_factor # KEGG_Brite ko03021 Transcription machinery # MISCELLANEOUS May only be involved in heat shocks that occur during exponential phase of growth under aerobic conditions. Different mechanisms may play a prime role during stationary phase and anaerobic growth (PubMed:16775749). {ECO 0000305|PubMed:16775749}. # Organism RPOH_ECOLI Escherichia coli (strain K12) # PATRIC 32122366 VBIEscCol129921_3560 # PIR H65142 RGECH # PIRSF PIRSF000770 RNA_pol_sigma-SigE/K # PRINTS PR00046 SIGMA70FCT # PROSITE PS00715 SIGMA70_1 # PROSITE PS00716 SIGMA70_2 # Pfam PF04542 Sigma70_r2 # Pfam PF04545 Sigma70_r4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RNA polymerase sigma factor RpoH {ECO:0000255|HAMAP-Rule MF_00961} # RefSeq NP_417918 NC_000913.3 # RefSeq WP_000130217 NZ_LN832404.1 # SIMILARITY Belongs to the sigma-70 factor family. RpoH subfamily. {ECO:0000255|HAMAP-Rule MF_00961}. # SUBCELLULAR LOCATION RPOH_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00961}. # SUBUNIT RPOH_ECOLI Interacts with the RNA polymerase core enzyme. Interacts with DnaK and DnaJ. {ECO 0000255|HAMAP-Rule MF_00961, ECO 0000269|PubMed 8599944, ECO 0000269|PubMed 9144163}. # SUPFAM SSF88659 SSF88659 # SUPFAM SSF88946 SSF88946 # TIGRFAMs TIGR02392 rpoH_proteo # TIGRFAMs TIGR02937 sigma70-ECF # eggNOG COG0568 LUCA # eggNOG ENOG4105DEK Bacteria BLAST swissprot:RPOH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RPOH_ECOLI BioCyc ECOL316407:JW3426-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3426-MONOMER BioCyc EcoCyc:RPOH-MONOMER http://biocyc.org/getid?id=EcoCyc:RPOH-MONOMER BioCyc MetaCyc:RPOH-MONOMER http://biocyc.org/getid?id=MetaCyc:RPOH-MONOMER COG COG0568 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0568 DIP DIP-46203N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-46203N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1007/s00203-006-0113-9 http://dx.doi.org/10.1007/s00203-006-0113-9 DOI 10.1016/0092-8674(84)90538-5 http://dx.doi.org/10.1016/0092-8674(84)90538-5 DOI 10.1038/329348a0 http://dx.doi.org/10.1038/329348a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1998.01091.x http://dx.doi.org/10.1046/j.1365-2958.1998.01091.x DOI 10.1073/pnas.81.21.6803 http://dx.doi.org/10.1073/pnas.81.21.6803 DOI 10.1073/pnas.94.10.4907 http://dx.doi.org/10.1073/pnas.94.10.4907 DOI 10.1074/jbc.M500393200 http://dx.doi.org/10.1074/jbc.M500393200 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1101/gad.1.2.179 http://dx.doi.org/10.1101/gad.1.2.179 DOI 10.1101/gad.1.5.419 http://dx.doi.org/10.1101/gad.1.5.419 DOI 10.1101/gad.13.6.655 http://dx.doi.org/10.1101/gad.13.6.655 DOI 10.1101/gad.1428206 http://dx.doi.org/10.1101/gad.1428206 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01536-08 http://dx.doi.org/10.1128/JB.01536-08 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J05516 http://www.ebi.ac.uk/ena/data/view/J05516 EMBL K02177 http://www.ebi.ac.uk/ena/data/view/K02177 EMBL M20668 http://www.ebi.ac.uk/ena/data/view/M20668 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0890 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0890 EcoGene EG10897 http://www.ecogene.org/geneInfo.php?eg_id=EG10897 EnsemblBacteria AAC76486 http://www.ensemblgenomes.org/id/AAC76486 EnsemblBacteria AAC76486 http://www.ensemblgenomes.org/id/AAC76486 EnsemblBacteria BAE77832 http://www.ensemblgenomes.org/id/BAE77832 EnsemblBacteria BAE77832 http://www.ensemblgenomes.org/id/BAE77832 EnsemblBacteria BAE77832 http://www.ensemblgenomes.org/id/BAE77832 EnsemblBacteria b3461 http://www.ensemblgenomes.org/id/b3461 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0000990 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000990 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0016987 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016987 GO_process GO:0001121 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001121 GO_process GO:0001123 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001123 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GO_process GO:0010468 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010468 GO_process GO:0030435 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030435 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0000988 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000988 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0030154 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0048646 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048646 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 947970 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947970 HAMAP MF_00961 http://hamap.expasy.org/unirule/MF_00961 HOGENOM HOG000270269 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000270269&db=HOGENOM6 InParanoid P0AGB3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGB3 IntAct P0AGB3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AGB3* InterPro IPR000943 http://www.ebi.ac.uk/interpro/entry/IPR000943 InterPro IPR007627 http://www.ebi.ac.uk/interpro/entry/IPR007627 InterPro IPR007630 http://www.ebi.ac.uk/interpro/entry/IPR007630 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR012759 http://www.ebi.ac.uk/interpro/entry/IPR012759 InterPro IPR013324 http://www.ebi.ac.uk/interpro/entry/IPR013324 InterPro IPR013325 http://www.ebi.ac.uk/interpro/entry/IPR013325 InterPro IPR014284 http://www.ebi.ac.uk/interpro/entry/IPR014284 InterPro IPR016263 http://www.ebi.ac.uk/interpro/entry/IPR016263 KEGG_Brite ko03021 http://www.genome.jp/dbget-bin/www_bget?ko03021 KEGG_Gene ecj:JW3426 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3426 KEGG_Gene eco:b3461 http://www.genome.jp/dbget-bin/www_bget?eco:b3461 KEGG_Orthology KO:K03089 http://www.genome.jp/dbget-bin/www_bget?KO:K03089 OMA LNNDEVH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LNNDEVH PRINTS PR00046 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00046 PROSITE PS00715 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00715 PROSITE PS00716 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00716 PSORT swissprot:RPOH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RPOH_ECOLI PSORT-B swissprot:RPOH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RPOH_ECOLI PSORT2 swissprot:RPOH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RPOH_ECOLI Pfam PF04542 http://pfam.xfam.org/family/PF04542 Pfam PF04545 http://pfam.xfam.org/family/PF04545 Phobius swissprot:RPOH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RPOH_ECOLI PhylomeDB P0AGB3 http://phylomedb.org/?seqid=P0AGB3 ProteinModelPortal P0AGB3 http://www.proteinmodelportal.org/query/uniprot/P0AGB3 PubMed 10090722 http://www.ncbi.nlm.nih.gov/pubmed/10090722 PubMed 15757896 http://www.ncbi.nlm.nih.gov/pubmed/15757896 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16775749 http://www.ncbi.nlm.nih.gov/pubmed/16775749 PubMed 16818608 http://www.ncbi.nlm.nih.gov/pubmed/16818608 PubMed 19114495 http://www.ncbi.nlm.nih.gov/pubmed/19114495 PubMed 2841288 http://www.ncbi.nlm.nih.gov/pubmed/2841288 PubMed 3306410 http://www.ncbi.nlm.nih.gov/pubmed/3306410 PubMed 3315848 http://www.ncbi.nlm.nih.gov/pubmed/3315848 PubMed 3315851 http://www.ncbi.nlm.nih.gov/pubmed/3315851 PubMed 6088062 http://www.ncbi.nlm.nih.gov/pubmed/6088062 PubMed 6387714 http://www.ncbi.nlm.nih.gov/pubmed/6387714 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 8599944 http://www.ncbi.nlm.nih.gov/pubmed/8599944 PubMed 9144163 http://www.ncbi.nlm.nih.gov/pubmed/9144163 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9822823 http://www.ncbi.nlm.nih.gov/pubmed/9822823 PubMed 9882652 http://www.ncbi.nlm.nih.gov/pubmed/9882652 RefSeq NP_417918 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417918 RefSeq WP_000130217 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000130217 SMR P0AGB3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AGB3 STRING 511145.b3461 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3461&targetmode=cogs STRING COG0568 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0568&targetmode=cogs SUPFAM SSF88659 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF88659 SUPFAM SSF88946 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF88946 TIGRFAMs TIGR02392 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02392 TIGRFAMs TIGR02937 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02937 UniProtKB RPOH_ECOLI http://www.uniprot.org/uniprot/RPOH_ECOLI UniProtKB-AC P0AGB3 http://www.uniprot.org/uniprot/P0AGB3 charge swissprot:RPOH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RPOH_ECOLI eggNOG COG0568 http://eggnogapi.embl.de/nog_data/html/tree/COG0568 eggNOG ENOG4105DEK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DEK epestfind swissprot:RPOH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RPOH_ECOLI garnier swissprot:RPOH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RPOH_ECOLI helixturnhelix swissprot:RPOH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RPOH_ECOLI hmoment swissprot:RPOH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RPOH_ECOLI iep swissprot:RPOH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RPOH_ECOLI inforesidue swissprot:RPOH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RPOH_ECOLI octanol swissprot:RPOH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RPOH_ECOLI pepcoil swissprot:RPOH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RPOH_ECOLI pepdigest swissprot:RPOH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RPOH_ECOLI pepinfo swissprot:RPOH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RPOH_ECOLI pepnet swissprot:RPOH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RPOH_ECOLI pepstats swissprot:RPOH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RPOH_ECOLI pepwheel swissprot:RPOH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RPOH_ECOLI pepwindow swissprot:RPOH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RPOH_ECOLI sigcleave swissprot:RPOH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RPOH_ECOLI ## Database ID URL or Descriptions # BioGrid 4260424 9 # EcoGene EG14054 yegK # GO_function GO:0003824 catalytic activity; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # InterPro IPR001932 PPM-type_phosphatase_dom # Organism YEGK_ECOLI Escherichia coli (strain K12) # PATRIC 32119477 VBIEscCol129921_2149 # PIR G64973 G64973 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEGK_ECOLI Uncharacterized protein YegK # RefSeq NP_416576 NC_000913.3 # SUPFAM SSF81606 SSF81606 # eggNOG ENOG4105UM3 Bacteria # eggNOG ENOG4111YVJ LUCA BLAST swissprot:YEGK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEGK_ECOLI BioCyc ECOL316407:JW2057-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2057-MONOMER BioCyc EcoCyc:G7111-MONOMER http://biocyc.org/getid?id=EcoCyc:G7111-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3807 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3807 EcoGene EG14054 http://www.ecogene.org/geneInfo.php?eg_id=EG14054 EnsemblBacteria AAC75133 http://www.ensemblgenomes.org/id/AAC75133 EnsemblBacteria AAC75133 http://www.ensemblgenomes.org/id/AAC75133 EnsemblBacteria BAE76579 http://www.ensemblgenomes.org/id/BAE76579 EnsemblBacteria BAE76579 http://www.ensemblgenomes.org/id/BAE76579 EnsemblBacteria BAE76579 http://www.ensemblgenomes.org/id/BAE76579 EnsemblBacteria b2072 http://www.ensemblgenomes.org/id/b2072 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003824 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003824 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GeneID 947269 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947269 HOGENOM HOG000122021 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122021&db=HOGENOM6 InterPro IPR001932 http://www.ebi.ac.uk/interpro/entry/IPR001932 KEGG_Gene ecj:JW2057 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2057 KEGG_Gene eco:b2072 http://www.genome.jp/dbget-bin/www_bget?eco:b2072 OMA CQDAHHW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CQDAHHW PSORT swissprot:YEGK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEGK_ECOLI PSORT-B swissprot:YEGK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEGK_ECOLI PSORT2 swissprot:YEGK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEGK_ECOLI Phobius swissprot:YEGK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEGK_ECOLI ProteinModelPortal P76395 http://www.proteinmodelportal.org/query/uniprot/P76395 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416576 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416576 STRING 511145.b2072 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2072&targetmode=cogs SUPFAM SSF81606 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81606 UniProtKB YEGK_ECOLI http://www.uniprot.org/uniprot/YEGK_ECOLI UniProtKB-AC P76395 http://www.uniprot.org/uniprot/P76395 charge swissprot:YEGK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEGK_ECOLI eggNOG ENOG4105UM3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105UM3 eggNOG ENOG4111YVJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111YVJ epestfind swissprot:YEGK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEGK_ECOLI garnier swissprot:YEGK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEGK_ECOLI helixturnhelix swissprot:YEGK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEGK_ECOLI hmoment swissprot:YEGK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEGK_ECOLI iep swissprot:YEGK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEGK_ECOLI inforesidue swissprot:YEGK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEGK_ECOLI octanol swissprot:YEGK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEGK_ECOLI pepcoil swissprot:YEGK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEGK_ECOLI pepdigest swissprot:YEGK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEGK_ECOLI pepinfo swissprot:YEGK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEGK_ECOLI pepnet swissprot:YEGK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEGK_ECOLI pepstats swissprot:YEGK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEGK_ECOLI pepwheel swissprot:YEGK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEGK_ECOLI pepwindow swissprot:YEGK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEGK_ECOLI sigcleave swissprot:YEGK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEGK_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES RISB_ECOLI Kinetic parameters KM=4.2 uM for 5-amino-6-(D-ribitylamino)uracil {ECO 0000269|PubMed 8969176}; KM=62 uM for 3,4-dihydroxy-2-butanone 4-phosphate {ECO 0000269|PubMed 8969176}; Vmax=11800 nmol/h/mg enzyme {ECO 0000269|PubMed 8969176}; # BioGrid 4259505 63 # CATALYTIC ACTIVITY 1-deoxy-L-glycero-tetrulose 4-phosphate + 5- amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(D- ribityl)lumazine + 2 H(2)O + phosphate. {ECO:0000269|PubMed 8969176}. # EcoGene EG11322 ribE # FUNCTION RISB_ECOLI Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. {ECO 0000269|PubMed 8969176}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0009349 riboflavin synthase complex; IEA:InterPro. # GO_function GO:0000906 6,7-dimethyl-8-ribityllumazine synthase activity; IDA:EcoCyc. # GO_function GO:0016740 transferase activity; IEA:UniProtKB-KW. # GO_process GO:0009231 riboflavin biosynthetic process; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.960 -; 1. # HAMAP MF_00178 Lumazine_synth # IntAct P61714 15 # InterPro IPR002180 DMRL_synthase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00740 Riboflavin metabolism # Organism RISB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21058 PTHR21058 # PATHWAY Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D- ribitylamino)uracil: step 1/2. {ECO 0000269|PubMed:8969176}. # PATRIC 32115979 VBIEscCol129921_0431 # PIR S26202 S26202 # Pfam PF00885 DMRL_synthase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RISB_ECOLI 6,7-dimethyl-8-ribityllumazine synthase # RefSeq NP_414949 NC_000913.3 # RefSeq WP_001021161 NZ_LN832404.1 # SIMILARITY Belongs to the DMRL synthase family. {ECO 0000305}. # SUBUNIT Forms a hollow icosahedral capsid composed of 60 subunits, probably arranged as a dodecamer of pentamers. Unlike in B.subtilis, does not interact with riboflavin synthase, and the core of the icosahedral capsid is empty. {ECO:0000269|PubMed 8969176}. # SUPFAM SSF52121 SSF52121 # TIGRFAMs TIGR00114 lumazine-synth # UniPathway UPA00275 UER00404 # eggNOG COG0054 LUCA # eggNOG ENOG4108UTT Bacteria BLAST swissprot:RISB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RISB_ECOLI BioCyc ECOL316407:JW0405-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0405-MONOMER BioCyc EcoCyc:LUMAZINESYN-MONOMER http://biocyc.org/getid?id=EcoCyc:LUMAZINESYN-MONOMER BioCyc MetaCyc:LUMAZINESYN-MONOMER http://biocyc.org/getid?id=MetaCyc:LUMAZINESYN-MONOMER COG COG0054 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0054 DIP DIP-10711N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10711N DOI 10.1007/BF00538702 http://dx.doi.org/10.1007/BF00538702 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.271.52.33201 http://dx.doi.org/10.1074/jbc.271.52.33201 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.5.1.78 http://www.genome.jp/dbget-bin/www_bget?EC:2.5.1.78 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL X64395 http://www.ebi.ac.uk/ena/data/view/X64395 ENZYME 2.5.1.78 http://enzyme.expasy.org/EC/2.5.1.78 EchoBASE EB1298 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1298 EcoGene EG11322 http://www.ecogene.org/geneInfo.php?eg_id=EG11322 EnsemblBacteria AAC73518 http://www.ensemblgenomes.org/id/AAC73518 EnsemblBacteria AAC73518 http://www.ensemblgenomes.org/id/AAC73518 EnsemblBacteria BAE76195 http://www.ensemblgenomes.org/id/BAE76195 EnsemblBacteria BAE76195 http://www.ensemblgenomes.org/id/BAE76195 EnsemblBacteria BAE76195 http://www.ensemblgenomes.org/id/BAE76195 EnsemblBacteria b0415 http://www.ensemblgenomes.org/id/b0415 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0009349 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009349 GO_function GO:0000906 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000906 GO_function GO:0016740 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016740 GO_process GO:0009231 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009231 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.960 http://www.cathdb.info/version/latest/superfamily/3.40.50.960 GeneID 946453 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946453 HAMAP MF_00178 http://hamap.expasy.org/unirule/MF_00178 HOGENOM HOG000229250 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000229250&db=HOGENOM6 InParanoid P61714 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P61714 IntAct P61714 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P61714* IntEnz 2.5.1.78 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.5.1.78 InterPro IPR002180 http://www.ebi.ac.uk/interpro/entry/IPR002180 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0405 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0405 KEGG_Gene eco:b0415 http://www.genome.jp/dbget-bin/www_bget?eco:b0415 KEGG_Orthology KO:K00794 http://www.genome.jp/dbget-bin/www_bget?KO:K00794 KEGG_Pathway ko00740 http://www.genome.jp/kegg-bin/show_pathway?ko00740 KEGG_Reaction rn:R04457 http://www.genome.jp/dbget-bin/www_bget?rn:R04457 MINT MINT-1225919 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1225919 OMA SHVAMNS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SHVAMNS PANTHER PTHR21058 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21058 PSORT swissprot:RISB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RISB_ECOLI PSORT-B swissprot:RISB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RISB_ECOLI PSORT2 swissprot:RISB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RISB_ECOLI Pfam PF00885 http://pfam.xfam.org/family/PF00885 Phobius swissprot:RISB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RISB_ECOLI PhylomeDB P61714 http://phylomedb.org/?seqid=P61714 ProteinModelPortal P61714 http://www.proteinmodelportal.org/query/uniprot/P61714 PubMed 1406588 http://www.ncbi.nlm.nih.gov/pubmed/1406588 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8969176 http://www.ncbi.nlm.nih.gov/pubmed/8969176 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414949 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414949 RefSeq WP_001021161 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001021161 SMR P61714 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P61714 STRING 511145.b0415 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0415&targetmode=cogs STRING COG0054 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0054&targetmode=cogs SUPFAM SSF52121 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52121 SWISS-2DPAGE P61714 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P61714 TIGRFAMs TIGR00114 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00114 UniProtKB RISB_ECOLI http://www.uniprot.org/uniprot/RISB_ECOLI UniProtKB-AC P61714 http://www.uniprot.org/uniprot/P61714 charge swissprot:RISB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RISB_ECOLI eggNOG COG0054 http://eggnogapi.embl.de/nog_data/html/tree/COG0054 eggNOG ENOG4108UTT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UTT epestfind swissprot:RISB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RISB_ECOLI garnier swissprot:RISB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RISB_ECOLI helixturnhelix swissprot:RISB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RISB_ECOLI hmoment swissprot:RISB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RISB_ECOLI iep swissprot:RISB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RISB_ECOLI inforesidue swissprot:RISB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RISB_ECOLI octanol swissprot:RISB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RISB_ECOLI pepcoil swissprot:RISB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RISB_ECOLI pepdigest swissprot:RISB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RISB_ECOLI pepinfo swissprot:RISB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RISB_ECOLI pepnet swissprot:RISB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RISB_ECOLI pepstats swissprot:RISB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RISB_ECOLI pepwheel swissprot:RISB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RISB_ECOLI pepwindow swissprot:RISB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RISB_ECOLI sigcleave swissprot:RISB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RISB_ECOLI ## Database ID URL or Descriptions # CAUTION Was originally described as a gef leader peptide. {ECO:0000305|PubMed 1943701}. # EcoGene EG12074 mokC # FUNCTION MOKC_ECOLI Overlapping regulatory peptide whose translation enables hokC expression. {ECO 0000305}. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # InterPro IPR000021 Hok/gef_toxin # InterPro IPR018084 Hok/gef_toxin_CS # Organism MOKC_ECOLI Escherichia coli (strain K12) # PATRIC 32115127 VBIEscCol129921_0015 # PRINTS PR00281 HOKGEFTOXIC # PROSITE PS00556 HOK_GEF # Pfam PF01848 HOK_GEF # ProDom PD005979 Hok/gef_toxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MOKC_ECOLI Regulatory protein MokC # RefSeq NP_414559 NC_000913.3 # SIMILARITY Belongs to the hok/gef family. {ECO 0000305}. # SUBCELLULAR LOCATION MOKC_ECOLI Membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. # eggNOG ENOG4105WI6 Bacteria # eggNOG ENOG41123E9 LUCA BLAST swissprot:MOKC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MOKC_ECOLI BioCyc ECOL316407:JW5879-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5879-MONOMER BioCyc EcoCyc:EG10373-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10373-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1999.01431.x http://dx.doi.org/10.1046/j.1365-2958.1999.01431.x DOI 10.1111/j.1365-2958.1991.tb01911.x http://dx.doi.org/10.1111/j.1365-2958.1991.tb01911.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1999 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1999 EcoGene EG12074 http://www.ecogene.org/geneInfo.php?eg_id=EG12074 EnsemblBacteria AAC73129 http://www.ensemblgenomes.org/id/AAC73129 EnsemblBacteria AAC73129 http://www.ensemblgenomes.org/id/AAC73129 EnsemblBacteria BAB96591 http://www.ensemblgenomes.org/id/BAB96591 EnsemblBacteria BAB96591 http://www.ensemblgenomes.org/id/BAB96591 EnsemblBacteria BAB96591 http://www.ensemblgenomes.org/id/BAB96591 EnsemblBacteria b0018 http://www.ensemblgenomes.org/id/b0018 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GeneID 944756 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944756 HOGENOM HOG000041219 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000041219&db=HOGENOM6 InterPro IPR000021 http://www.ebi.ac.uk/interpro/entry/IPR000021 InterPro IPR018084 http://www.ebi.ac.uk/interpro/entry/IPR018084 KEGG_Gene ecj:JW5879 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5879 KEGG_Gene eco:b0018 http://www.genome.jp/dbget-bin/www_bget?eco:b0018 OMA HKVMIVA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HKVMIVA PRINTS PR00281 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00281 PROSITE PS00556 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00556 PSORT swissprot:MOKC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MOKC_ECOLI PSORT-B swissprot:MOKC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MOKC_ECOLI PSORT2 swissprot:MOKC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MOKC_ECOLI Pfam PF01848 http://pfam.xfam.org/family/PF01848 Phobius swissprot:MOKC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MOKC_ECOLI PhylomeDB P33236 http://phylomedb.org/?seqid=P33236 ProteinModelPortal P33236 http://www.proteinmodelportal.org/query/uniprot/P33236 PubMed 10361310 http://www.ncbi.nlm.nih.gov/pubmed/10361310 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1943701 http://www.ncbi.nlm.nih.gov/pubmed/1943701 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414559 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414559 STRING 511145.b0018 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0018&targetmode=cogs UniProtKB MOKC_ECOLI http://www.uniprot.org/uniprot/MOKC_ECOLI UniProtKB-AC P33236 http://www.uniprot.org/uniprot/P33236 charge swissprot:MOKC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MOKC_ECOLI eggNOG ENOG4105WI6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105WI6 eggNOG ENOG41123E9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41123E9 epestfind swissprot:MOKC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MOKC_ECOLI garnier swissprot:MOKC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MOKC_ECOLI helixturnhelix swissprot:MOKC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MOKC_ECOLI hmoment swissprot:MOKC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MOKC_ECOLI iep swissprot:MOKC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MOKC_ECOLI inforesidue swissprot:MOKC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MOKC_ECOLI octanol swissprot:MOKC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MOKC_ECOLI pepcoil swissprot:MOKC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MOKC_ECOLI pepdigest swissprot:MOKC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MOKC_ECOLI pepinfo swissprot:MOKC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MOKC_ECOLI pepnet swissprot:MOKC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MOKC_ECOLI pepstats swissprot:MOKC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MOKC_ECOLI pepwheel swissprot:MOKC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MOKC_ECOLI pepwindow swissprot:MOKC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MOKC_ECOLI sigcleave swissprot:MOKC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MOKC_ECOLI ## Database ID URL or Descriptions # AltName MDTA_ECOLI Multidrug transporter MdtA # BioGrid 4260423 135 # EcoGene EG14056 mdtA # FUNCTION MDTA_ECOLI The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate. MdtABC requires TolC for its function. {ECO 0000269|PubMed 12107133, ECO 0000269|PubMed 12107134}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_function GO:0005215 transporter activity; IEA:UniProtKB-HAMAP. # GO_process GO:0055085 transmembrane transport; IEA:InterPro. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0055085 transmembrane transport # HAMAP MF_01422 MdtA # INDUCTION MDTA_ECOLI The mdtABC operon is transcriptionally activated by BaeR. {ECO 0000269|PubMed 12107133, ECO 0000269|PubMed 12107134}. # InterPro IPR006143 RND_pump_MFP # InterPro IPR022824 Multidrug-R_MdtA # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko02020 Two-component system # Organism MDTA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30469:SF12 PTHR30469:SF12; 2 # PATRIC 32119481 VBIEscCol129921_2151 # PIR A64974 A64974 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MDTA_ECOLI Multidrug resistance protein MdtA # RefSeq NP_416578 NC_000913.3 # RefSeq WP_000678989 NZ_LN832404.1 # SIMILARITY Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. {ECO 0000305}. # SUBCELLULAR LOCATION MDTA_ECOLI Cell inner membrane {ECO 0000305}; Peripheral membrane protein {ECO 0000305}. # SUBUNIT MDTA_ECOLI Part of a tripartite efflux system composed of MdtA, MdtB and MdtC. # TCDB 8.A.1.6 the membrane fusion protein (mfp) family # TIGRFAMs TIGR01730 RND_mfp # eggNOG ENOG4105ENT Bacteria # eggNOG ENOG410XSF7 LUCA BLAST swissprot:MDTA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MDTA_ECOLI BioCyc ECOL316407:JW5338-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5338-MONOMER BioCyc EcoCyc:MDTA http://biocyc.org/getid?id=EcoCyc:MDTA COG COG0845 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0845 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.15.4161-4167.2002 http://dx.doi.org/10.1128/JB.184.15.4161-4167.2002 DOI 10.1128/JB.184.15.4168-4176.2002 http://dx.doi.org/10.1128/JB.184.15.4168-4176.2002 EMBL AB089187 http://www.ebi.ac.uk/ena/data/view/AB089187 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3809 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3809 EcoGene EG14056 http://www.ecogene.org/geneInfo.php?eg_id=EG14056 EnsemblBacteria AAC75135 http://www.ensemblgenomes.org/id/AAC75135 EnsemblBacteria AAC75135 http://www.ensemblgenomes.org/id/AAC75135 EnsemblBacteria BAA15928 http://www.ensemblgenomes.org/id/BAA15928 EnsemblBacteria BAA15928 http://www.ensemblgenomes.org/id/BAA15928 EnsemblBacteria BAA15928 http://www.ensemblgenomes.org/id/BAA15928 EnsemblBacteria b2074 http://www.ensemblgenomes.org/id/b2074 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 946604 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946604 HAMAP MF_01422 http://hamap.expasy.org/unirule/MF_01422 HOGENOM HOG000158248 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000158248&db=HOGENOM6 InParanoid P76397 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76397 InterPro IPR006143 http://www.ebi.ac.uk/interpro/entry/IPR006143 InterPro IPR022824 http://www.ebi.ac.uk/interpro/entry/IPR022824 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW5338 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5338 KEGG_Gene eco:b2074 http://www.genome.jp/dbget-bin/www_bget?eco:b2074 KEGG_Orthology KO:K07799 http://www.genome.jp/dbget-bin/www_bget?KO:K07799 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA QELDTQQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QELDTQQ PANTHER PTHR30469:SF12 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30469:SF12 PSORT swissprot:MDTA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MDTA_ECOLI PSORT-B swissprot:MDTA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MDTA_ECOLI PSORT2 swissprot:MDTA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MDTA_ECOLI Phobius swissprot:MDTA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MDTA_ECOLI PhylomeDB P76397 http://phylomedb.org/?seqid=P76397 ProteinModelPortal P76397 http://www.proteinmodelportal.org/query/uniprot/P76397 PubMed 12107133 http://www.ncbi.nlm.nih.gov/pubmed/12107133 PubMed 12107134 http://www.ncbi.nlm.nih.gov/pubmed/12107134 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416578 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416578 RefSeq WP_000678989 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000678989 SMR P76397 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76397 STRING 511145.b2074 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2074&targetmode=cogs STRING COG0845 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0845&targetmode=cogs TCDB 8.A.1.6 http://www.tcdb.org/search/result.php?tc=8.A.1.6 TIGRFAMs TIGR01730 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01730 UniProtKB MDTA_ECOLI http://www.uniprot.org/uniprot/MDTA_ECOLI UniProtKB-AC P76397 http://www.uniprot.org/uniprot/P76397 charge swissprot:MDTA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MDTA_ECOLI eggNOG ENOG4105ENT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ENT eggNOG ENOG410XSF7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XSF7 epestfind swissprot:MDTA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MDTA_ECOLI garnier swissprot:MDTA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MDTA_ECOLI helixturnhelix swissprot:MDTA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MDTA_ECOLI hmoment swissprot:MDTA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MDTA_ECOLI iep swissprot:MDTA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MDTA_ECOLI inforesidue swissprot:MDTA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MDTA_ECOLI octanol swissprot:MDTA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MDTA_ECOLI pepcoil swissprot:MDTA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MDTA_ECOLI pepdigest swissprot:MDTA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MDTA_ECOLI pepinfo swissprot:MDTA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MDTA_ECOLI pepnet swissprot:MDTA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MDTA_ECOLI pepstats swissprot:MDTA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MDTA_ECOLI pepwheel swissprot:MDTA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MDTA_ECOLI pepwindow swissprot:MDTA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MDTA_ECOLI sigcleave swissprot:MDTA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MDTA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260514 13 # COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI 18420; Evidence={ECO:0000250}; # EcoGene EG14107 yfcD # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0016817 hydrolase activity, acting on acid anhydrides; IEA:InterPro. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # Gene3D 3.90.79.10 -; 1. # INTERACTION YFCD_ECOLI P31663 panC; NbExp=5; IntAct=EBI-545346, EBI-545354; # IntAct P65556 4 # InterPro IPR000086 NUDIX_hydrolase_dom # InterPro IPR015797 NUDIX_hydrolase_dom-like # InterPro IPR024195 NUDIX_hydrolase_YfcD_pred # KEGG_Brite ko01000 Enzymes # Organism YFCD_ECOLI Escherichia coli (strain K12) # PATRIC 32119969 VBIEscCol129921_2394 # PDB 2FKB X-ray; 2.00 A; A/B/C=1-180 # PIR A65002 A65002 # PIRSF PIRSF017340 Nudix_hydro # PROSITE PS51462 NUDIX # Pfam PF00293 NUDIX # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFCD_ECOLI Uncharacterized Nudix hydrolase YfcD # RefSeq NP_416802 NC_000913.3 # RefSeq WP_000437935 NZ_LN832404.1 # SIMILARITY Belongs to the Nudix hydrolase family. {ECO 0000305}. # SIMILARITY Contains 1 nudix hydrolase domain. {ECO:0000255|PROSITE-ProRule PRU00794}. # SUPFAM SSF55811 SSF55811 # eggNOG ENOG4105PTV Bacteria # eggNOG ENOG410ZCV3 LUCA BLAST swissprot:YFCD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFCD_ECOLI BioCyc ECOL316407:JW2296-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2296-MONOMER BioCyc EcoCyc:G7191-MONOMER http://biocyc.org/getid?id=EcoCyc:G7191-MONOMER DIP DIP-28086N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-28086N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.6.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.6.-.- http://enzyme.expasy.org/EC/3.6.-.- EchoBASE EB3860 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3860 EcoGene EG14107 http://www.ecogene.org/geneInfo.php?eg_id=EG14107 EnsemblBacteria AAC75359 http://www.ensemblgenomes.org/id/AAC75359 EnsemblBacteria AAC75359 http://www.ensemblgenomes.org/id/AAC75359 EnsemblBacteria BAE76686 http://www.ensemblgenomes.org/id/BAE76686 EnsemblBacteria BAE76686 http://www.ensemblgenomes.org/id/BAE76686 EnsemblBacteria BAE76686 http://www.ensemblgenomes.org/id/BAE76686 EnsemblBacteria b2299 http://www.ensemblgenomes.org/id/b2299 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0016817 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016817 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.90.79.10 http://www.cathdb.info/version/latest/superfamily/3.90.79.10 GeneID 946783 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946783 HOGENOM HOG000274108 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000274108&db=HOGENOM6 InParanoid P65556 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P65556 IntAct P65556 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P65556* IntEnz 3.6 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6 InterPro IPR000086 http://www.ebi.ac.uk/interpro/entry/IPR000086 InterPro IPR015797 http://www.ebi.ac.uk/interpro/entry/IPR015797 InterPro IPR024195 http://www.ebi.ac.uk/interpro/entry/IPR024195 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2296 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2296 KEGG_Gene eco:b2299 http://www.genome.jp/dbget-bin/www_bget?eco:b2299 KEGG_Orthology KO:K01554 http://www.genome.jp/dbget-bin/www_bget?KO:K01554 OMA GYWDVAA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GYWDVAA PDB 2FKB http://www.ebi.ac.uk/pdbe-srv/view/entry/2FKB PDBsum 2FKB http://www.ebi.ac.uk/pdbsum/2FKB PROSITE PS51462 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51462 PSORT swissprot:YFCD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFCD_ECOLI PSORT-B swissprot:YFCD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFCD_ECOLI PSORT2 swissprot:YFCD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFCD_ECOLI Pfam PF00293 http://pfam.xfam.org/family/PF00293 Phobius swissprot:YFCD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFCD_ECOLI PhylomeDB P65556 http://phylomedb.org/?seqid=P65556 ProteinModelPortal P65556 http://www.proteinmodelportal.org/query/uniprot/P65556 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416802 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416802 RefSeq WP_000437935 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000437935 SMR P65556 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P65556 STRING 511145.b2299 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2299&targetmode=cogs SUPFAM SSF55811 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55811 UniProtKB YFCD_ECOLI http://www.uniprot.org/uniprot/YFCD_ECOLI UniProtKB-AC P65556 http://www.uniprot.org/uniprot/P65556 charge swissprot:YFCD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFCD_ECOLI eggNOG ENOG4105PTV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105PTV eggNOG ENOG410ZCV3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZCV3 epestfind swissprot:YFCD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFCD_ECOLI garnier swissprot:YFCD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFCD_ECOLI helixturnhelix swissprot:YFCD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFCD_ECOLI hmoment swissprot:YFCD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFCD_ECOLI iep swissprot:YFCD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFCD_ECOLI inforesidue swissprot:YFCD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFCD_ECOLI octanol swissprot:YFCD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFCD_ECOLI pepcoil swissprot:YFCD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFCD_ECOLI pepdigest swissprot:YFCD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFCD_ECOLI pepinfo swissprot:YFCD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFCD_ECOLI pepnet swissprot:YFCD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFCD_ECOLI pepstats swissprot:YFCD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFCD_ECOLI pepwheel swissprot:YFCD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFCD_ECOLI pepwindow swissprot:YFCD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFCD_ECOLI sigcleave swissprot:YFCD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFCD_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES PCKA_ECOLI Kinetic parameters KM=3.8 uM for manganese (at 31 degrees Celsius and pH 7.5) {ECO 0000269|PubMed 17475535, ECO 0000269|PubMed 6986370}; KM=0.11 mM for calcium (at 31 degrees Celsius and pH 7.5) {ECO 0000269|PubMed 17475535, ECO 0000269|PubMed 6986370}; KM=0.31 mM for OAA (at 31 degrees Celsius and pH 7.5) {ECO 0000269|PubMed 17475535, ECO 0000269|PubMed 6986370}; KM=0.51 mM for OAA (at pH 7.5) {ECO 0000269|PubMed 17475535, ECO 0000269|PubMed 6986370}; KM=1.4 mM for magnesium (at 31 degrees Celsius and pH 7.5) {ECO 0000269|PubMed 17475535, ECO 0000269|PubMed 6986370}; KM=11 mM for PEP (at pH 7.5) {ECO 0000269|PubMed 17475535, ECO 0000269|PubMed 6986370}; # BRENDA 4.1.1.49 2026 # CATALYTIC ACTIVITY PCKA_ECOLI ATP + oxaloacetate = ADP + phosphoenolpyruvate + CO(2). {ECO 0000255|HAMAP-Rule MF_00453, ECO 0000269|PubMed 6986370}. # CDD cd00484 PEPCK_ATP # COFACTOR PCKA_ECOLI Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000255|HAMAP-Rule MF_00453, ECO 0000269|PubMed 1701430, ECO 0000269|PubMed 17475535, ECO 0000269|PubMed 9406547, ECO 0000269|Ref.20, ECO 0000269|Ref.21}; Note=Binds 1 Mn(2+) ion per subunit. {ECO 0000255|HAMAP- Rule MF_00453, ECO 0000269|PubMed 1701430, ECO 0000269|PubMed 17475535, ECO 0000269|PubMed 9406547, ECO 0000269|Ref.20, ECO 0000269|Ref.21}; # ENZYME REGULATION PCKA_ECOLI Allosterically activated by calcium. It may represent the only case of a monomeric, allosteric enzyme. {ECO 0000269|PubMed 12837799, ECO 0000269|PubMed 1701430, ECO 0000269|PubMed 6986370, ECO 0000269|PubMed 8609605}. # EcoGene EG10688 pck # FUNCTION PCKA_ECOLI Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. {ECO 0000255|HAMAP-Rule MF_00453, ECO 0000269|PubMed 1701430, ECO 0000269|PubMed 6986370, ECO 0000269|PubMed 8226637}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0004612 phosphoenolpyruvate carboxykinase (ATP) activity; IDA:EcoCyc. # GO_function GO:0005509 calcium ion binding; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006094 gluconeogenesis; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.449.10 -; 1. # Gene3D 3.90.228.20 -; 2. # HAMAP MF_00453 PEPCK_ATP # INDUCTION PCKA_ECOLI Induced upon entry into stationary phase and by cyclic AMP (cAMP). Repressed by glucose (catabolite repression) and by CsrA. {ECO 0000269|PubMed 6434512, ECO 0000269|PubMed 8393005}. # IntAct P22259 4 # InterPro IPR001272 PEP_carboxykinase_ATP # InterPro IPR008210 PEP_carboxykinase_N # InterPro IPR013035 PEP_carboxykinase_C # InterPro IPR015994 PEPCK_ATP_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00010 Glycolysis / Gluconeogenesis # KEGG_Pathway ko00020 Citrate cycle (TCA cycle) # KEGG_Pathway ko00620 Pyruvate metabolism # KEGG_Pathway ko00710 Carbon fixation in photosynthetic organisms # MASS SPECTROMETRY Mass=59656; Method=Electrospray; Range=1-540; Evidence={ECO:0000269|PubMed 8609605}; # Organism PCKA_ECOLI Escherichia coli (strain K12) # PATHWAY Carbohydrate biosynthesis; gluconeogenesis. {ECO:0000255|HAMAP-Rule MF_00453}. # PATRIC 32122242 VBIEscCol129921_3498 # PDB 1AQ2 X-ray; 1.90 A; A=1-540 # PDB 1AYL X-ray; 1.80 A; A=1-540 # PDB 1K3C X-ray; 2.00 A; A=1-540 # PDB 1K3D X-ray; 2.00 A; A=1-540 # PDB 1OEN X-ray; 1.90 A; A=1-538 # PDB 1OS1 X-ray; 1.80 A; A=1-540 # PDB 2OLQ X-ray; 1.94 A; A=1-540 # PDB 2OLR X-ray; 1.60 A; A=1-540 # PDB 2PXZ X-ray; 2.23 A; X=1-540 # PDB 2PY7 X-ray; 2.20 A; X=1-540 # PIR F65135 F65135 # PIRSF PIRSF006294 PEP_crbxkin # PROSITE PS00532 PEPCK_ATP # Pfam PF01293 PEPCK_ATP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Phosphoenolpyruvate carboxykinase [ATP] {ECO:0000255|HAMAP-Rule MF_00453} # RefSeq NP_417862 NC_000913.3 # RefSeq WP_001265681 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA24301.1; Type=Frameshift; Positions=456; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the phosphoenolpyruvate carboxykinase [ATP] family. {ECO:0000255|HAMAP-Rule MF_00453}. # SUBCELLULAR LOCATION PCKA_ECOLI Cytoplasm. # SUBUNIT PCKA_ECOLI Monomer. {ECO 0000255|HAMAP-Rule MF_00453, ECO 0000269|PubMed 11724534, ECO 0000269|PubMed 12837799, ECO 0000269|PubMed 1701430, ECO 0000269|PubMed 17475535, ECO 0000269|PubMed 6986370, ECO 0000269|PubMed 8599762, ECO 0000269|PubMed 9406547, ECO 0000269|Ref.20, ECO 0000269|Ref.21}. # SUPFAM SSF68923 SSF68923 # TIGRFAMs TIGR00224 pckA # eggNOG COG1866 LUCA # eggNOG ENOG4105DJ1 Bacteria BLAST swissprot:PCKA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PCKA_ECOLI BioCyc ECOL316407:JW3366-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3366-MONOMER BioCyc EcoCyc:PEPCARBOXYKIN-MONOMER http://biocyc.org/getid?id=EcoCyc:PEPCARBOXYKIN-MONOMER BioCyc MetaCyc:PEPCARBOXYKIN-MONOMER http://biocyc.org/getid?id=MetaCyc:PEPCARBOXYKIN-MONOMER COG COG1866 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1866 DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1996.0072 http://dx.doi.org/10.1006/jmbi.1996.0072 DOI 10.1006/jmbi.2001.5120 http://dx.doi.org/10.1006/jmbi.2001.5120 DOI 10.1016/j.biocel.2007.03.015 http://dx.doi.org/10.1016/j.biocel.2007.03.015 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb0496-355 http://dx.doi.org/10.1038/nsb0496-355 DOI 10.1038/nsb1297-990 http://dx.doi.org/10.1038/nsb1297-990 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1111/j.1365-2958.1995.tb02339.x http://dx.doi.org/10.1111/j.1365-2958.1995.tb02339.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.185.14.4233-4242.2003 http://dx.doi.org/10.1128/JB.185.14.4233-4242.2003 EC_number EC:4.1.1.49 {ECO:0000255|HAMAP-Rule:MF_00453} http://www.genome.jp/dbget-bin/www_bget?EC:4.1.1.49 {ECO:0000255|HAMAP-Rule:MF_00453} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01656 http://www.ebi.ac.uk/ena/data/view/J01656 EMBL M59823 http://www.ebi.ac.uk/ena/data/view/M59823 EMBL S76268 http://www.ebi.ac.uk/ena/data/view/S76268 EMBL S76269 http://www.ebi.ac.uk/ena/data/view/S76269 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL U21325 http://www.ebi.ac.uk/ena/data/view/U21325 ENZYME 4.1.1.49 {ECO:0000255|HAMAP-Rule:MF_00453} http://enzyme.expasy.org/EC/4.1.1.49 {ECO:0000255|HAMAP-Rule:MF_00453} EchoBASE EB0682 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0682 EcoGene EG10688 http://www.ecogene.org/geneInfo.php?eg_id=EG10688 EnsemblBacteria AAC76428 http://www.ensemblgenomes.org/id/AAC76428 EnsemblBacteria AAC76428 http://www.ensemblgenomes.org/id/AAC76428 EnsemblBacteria BAE77888 http://www.ensemblgenomes.org/id/BAE77888 EnsemblBacteria BAE77888 http://www.ensemblgenomes.org/id/BAE77888 EnsemblBacteria BAE77888 http://www.ensemblgenomes.org/id/BAE77888 EnsemblBacteria b3403 http://www.ensemblgenomes.org/id/b3403 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0004612 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004612 GO_function GO:0005509 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006094 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006094 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.449.10 http://www.cathdb.info/version/latest/superfamily/3.40.449.10 Gene3D 3.90.228.20 http://www.cathdb.info/version/latest/superfamily/3.90.228.20 GeneID 945667 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945667 HAMAP MF_00453 http://hamap.expasy.org/unirule/MF_00453 HOGENOM HOG000271471 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000271471&db=HOGENOM6 InParanoid P22259 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P22259 IntAct P22259 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P22259* IntEnz 4.1.1.49 {ECO:0000255|HAMAP-Rule:MF_00453} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.1.49 {ECO:0000255|HAMAP-Rule:MF_00453} InterPro IPR001272 http://www.ebi.ac.uk/interpro/entry/IPR001272 InterPro IPR008210 http://www.ebi.ac.uk/interpro/entry/IPR008210 InterPro IPR013035 http://www.ebi.ac.uk/interpro/entry/IPR013035 InterPro IPR015994 http://www.ebi.ac.uk/interpro/entry/IPR015994 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3366 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3366 KEGG_Gene eco:b3403 http://www.genome.jp/dbget-bin/www_bget?eco:b3403 KEGG_Orthology KO:K01610 http://www.genome.jp/dbget-bin/www_bget?KO:K01610 KEGG_Pathway ko00010 http://www.genome.jp/kegg-bin/show_pathway?ko00010 KEGG_Pathway ko00020 http://www.genome.jp/kegg-bin/show_pathway?ko00020 KEGG_Pathway ko00620 http://www.genome.jp/kegg-bin/show_pathway?ko00620 KEGG_Pathway ko00710 http://www.genome.jp/kegg-bin/show_pathway?ko00710 KEGG_Reaction rn:R00341 http://www.genome.jp/dbget-bin/www_bget?rn:R00341 OMA RFIVKEP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RFIVKEP PDB 1AQ2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1AQ2 PDB 1AYL http://www.ebi.ac.uk/pdbe-srv/view/entry/1AYL PDB 1K3C http://www.ebi.ac.uk/pdbe-srv/view/entry/1K3C PDB 1K3D http://www.ebi.ac.uk/pdbe-srv/view/entry/1K3D PDB 1OEN http://www.ebi.ac.uk/pdbe-srv/view/entry/1OEN PDB 1OS1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1OS1 PDB 2OLQ http://www.ebi.ac.uk/pdbe-srv/view/entry/2OLQ PDB 2OLR http://www.ebi.ac.uk/pdbe-srv/view/entry/2OLR PDB 2PXZ http://www.ebi.ac.uk/pdbe-srv/view/entry/2PXZ PDB 2PY7 http://www.ebi.ac.uk/pdbe-srv/view/entry/2PY7 PDBsum 1AQ2 http://www.ebi.ac.uk/pdbsum/1AQ2 PDBsum 1AYL http://www.ebi.ac.uk/pdbsum/1AYL PDBsum 1K3C http://www.ebi.ac.uk/pdbsum/1K3C PDBsum 1K3D http://www.ebi.ac.uk/pdbsum/1K3D PDBsum 1OEN http://www.ebi.ac.uk/pdbsum/1OEN PDBsum 1OS1 http://www.ebi.ac.uk/pdbsum/1OS1 PDBsum 2OLQ http://www.ebi.ac.uk/pdbsum/2OLQ PDBsum 2OLR http://www.ebi.ac.uk/pdbsum/2OLR PDBsum 2PXZ http://www.ebi.ac.uk/pdbsum/2PXZ PDBsum 2PY7 http://www.ebi.ac.uk/pdbsum/2PY7 PROSITE PS00532 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00532 PSORT swissprot:PCKA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PCKA_ECOLI PSORT-B swissprot:PCKA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PCKA_ECOLI PSORT2 swissprot:PCKA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PCKA_ECOLI Pfam PF01293 http://pfam.xfam.org/family/PF01293 Phobius swissprot:PCKA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PCKA_ECOLI PhylomeDB P22259 http://phylomedb.org/?seqid=P22259 ProteinModelPortal P22259 http://www.proteinmodelportal.org/query/uniprot/P22259 PubMed 11724534 http://www.ncbi.nlm.nih.gov/pubmed/11724534 PubMed 12837799 http://www.ncbi.nlm.nih.gov/pubmed/12837799 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1701430 http://www.ncbi.nlm.nih.gov/pubmed/1701430 PubMed 17475535 http://www.ncbi.nlm.nih.gov/pubmed/17475535 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 6292200 http://www.ncbi.nlm.nih.gov/pubmed/6292200 PubMed 6434512 http://www.ncbi.nlm.nih.gov/pubmed/6434512 PubMed 6986370 http://www.ncbi.nlm.nih.gov/pubmed/6986370 PubMed 7883719 http://www.ncbi.nlm.nih.gov/pubmed/7883719 PubMed 8226637 http://www.ncbi.nlm.nih.gov/pubmed/8226637 PubMed 8393005 http://www.ncbi.nlm.nih.gov/pubmed/8393005 PubMed 8577250 http://www.ncbi.nlm.nih.gov/pubmed/8577250 PubMed 8599762 http://www.ncbi.nlm.nih.gov/pubmed/8599762 PubMed 8609605 http://www.ncbi.nlm.nih.gov/pubmed/8609605 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9406547 http://www.ncbi.nlm.nih.gov/pubmed/9406547 RefSeq NP_417862 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417862 RefSeq WP_001265681 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001265681 SMR P22259 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P22259 STRING 511145.b3403 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3403&targetmode=cogs STRING COG1866 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1866&targetmode=cogs SUPFAM SSF68923 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF68923 TIGRFAMs TIGR00224 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00224 UniProtKB PCKA_ECOLI http://www.uniprot.org/uniprot/PCKA_ECOLI UniProtKB-AC P22259 http://www.uniprot.org/uniprot/P22259 charge swissprot:PCKA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PCKA_ECOLI eggNOG COG1866 http://eggnogapi.embl.de/nog_data/html/tree/COG1866 eggNOG ENOG4105DJ1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DJ1 epestfind swissprot:PCKA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PCKA_ECOLI garnier swissprot:PCKA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PCKA_ECOLI helixturnhelix swissprot:PCKA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PCKA_ECOLI hmoment swissprot:PCKA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PCKA_ECOLI iep swissprot:PCKA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PCKA_ECOLI inforesidue swissprot:PCKA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PCKA_ECOLI octanol swissprot:PCKA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PCKA_ECOLI pepcoil swissprot:PCKA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PCKA_ECOLI pepdigest swissprot:PCKA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PCKA_ECOLI pepinfo swissprot:PCKA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PCKA_ECOLI pepnet swissprot:PCKA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PCKA_ECOLI pepstats swissprot:PCKA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PCKA_ECOLI pepwheel swissprot:PCKA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PCKA_ECOLI pepwindow swissprot:PCKA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PCKA_ECOLI sigcleave swissprot:PCKA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PCKA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260094 15 # CDD cd00383 trans_reg_C # DISRUPTION PHENOTYPE Altered expression of 33 genes; 9 are down- regulated, the rest up-regulated. {ECO:0000269|PubMed 15703297}. # ENZYME REGULATION PHOP_ECOLI Feedback inhibited by MgrB, which seems to bind PhoQ, altering its activity and that of downstream effector PhoP. PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing (deletion of dsbA/dsbB, or treatment with dithiothreitol). MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway. {ECO 0000269|PubMed 20041203, ECO 0000269|PubMed 22267510}. # EcoGene EG10731 phoP # FUNCTION PHOP_ECOLI Member of the two-component regulatory system PhoP/PhoQ involved in adaptation to low Mg(2+) environments and the control of acid resistance genes. In low periplasmic Mg(2+), PhoQ phosphorylates PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), PhoQ dephosphorylates phospho-PhoP, resulting in the repression of PAG and may lead to expression of some PRG (By similarity). Mediates magnesium influx to the cytosol by activation of MgtA. Promotes expression of the two-component regulatory system rstA/rstB and transcription of the hemL, mgrB, nagA, slyB, vboR and yrbL genes. {ECO 0000250, ECO 0000269|PubMed 10464230}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0042802 identical protein binding; IPI:IntAct. # GO_process GO:0000160 phosphorelay signal transduction system; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # INDUCTION PHOP_ECOLI The phoP/phoQ operon is positively autoregulated by both PhoP and PhoQ in a Mg(2+)-dependent manner, inhibited at high Mg(2+) concentrations (PubMed 10464230). Induced by dsbA disruption and dithiothreitol (PubMed 22267510). {ECO 0000269|PubMed 10464230, ECO 0000269|PubMed 22267510}. # INTERACTION PHOP_ECOLI Self; NbExp=5; IntAct=EBI-1121453, EBI-1121453; # IntAct P23836 5 # InterPro IPR001789 Sig_transdc_resp-reg_receiver # InterPro IPR001867 OmpR/PhoB-type_DNA-bd # InterPro IPR011006 CheY-like_superfamily # InterPro IPR011991 WHTH_DNA-bd_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02022 M00444 PhoQ-PhoP (magnesium transport) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # MISCELLANEOUS PHOP_ECOLI There is a close linkage between the Rcs and PhoQ/P signaling systems, and both signaling systems respond to certain external divalent cations (zinc and magnesium). # MISCELLANEOUS PHOP_ECOLI Two-component regulatory system EvgA/EvgS interacts with PhoP/PhoQ via signal transduction mediated by phospho-EvgA. # Organism PHOP_ECOLI Escherichia coli (strain K12) # PATRIC 32117509 VBIEscCol129921_1177 # PDB 2PKX X-ray; 2.54 A; A/B=1-121 # PDB 2PL1 X-ray; 1.90 A; A=1-121 # PIR A41965 A41965 # PROSITE PS50110 RESPONSE_REGULATORY # PROSITE PS51755 OMPR_PHOB # PTM PHOP_ECOLI Phosphorylated by PhoQ. {ECO 0000305}. # Pfam PF00072 Response_reg # Pfam PF00486 Trans_reg_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PHOP_ECOLI Transcriptional regulatory protein PhoP # RefSeq NP_415648 NC_000913.3 # RefSeq WP_001265471 NZ_LN832404.1 # SIMILARITY Contains 1 OmpR/PhoB-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU01091}. # SIMILARITY Contains 1 response regulatory domain. {ECO:0000255|PROSITE-ProRule PRU00169}. # SMART SM00448 REC # SMART SM00862 Trans_reg_C # SUBCELLULAR LOCATION PHOP_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Monomer in the inactive, unphosphorylated state and dimer in the active, phosphorylated state. {ECO:0000305|PubMed 17545283}. # SUPFAM SSF52172 SSF52172 # eggNOG ENOG4105XJC Bacteria # eggNOG ENOG4111FPD LUCA BLAST swissprot:PHOP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PHOP_ECOLI BioCyc ECOL316407:JW1116-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1116-MONOMER BioCyc EcoCyc:PHOP-MONOMER http://biocyc.org/getid?id=EcoCyc:PHOP-MONOMER COG COG0745 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0745 DIP DIP-10500N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10500N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2002.03017.x http://dx.doi.org/10.1046/j.1365-2958.2002.03017.x DOI 10.1073/pnas.0408238102 http://dx.doi.org/10.1073/pnas.0408238102 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00049-07 http://dx.doi.org/10.1128/JB.00049-07 DOI 10.1128/JB.06055-11 http://dx.doi.org/10.1128/JB.06055-11 DOI 10.1128/JB.185.13.3696-3702.2003 http://dx.doi.org/10.1128/JB.185.13.3696-3702.2003 DOI 10.1128/JB.185.19.5735-5746.2003 http://dx.doi.org/10.1128/JB.185.19.5735-5746.2003 DOI 10.1128/JB.186.10.3006-3014.2004 http://dx.doi.org/10.1128/JB.186.10.3006-3014.2004 DOI 10.1371/journal.pgen.1000788 http://dx.doi.org/10.1371/journal.pgen.1000788 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D90393 http://www.ebi.ac.uk/ena/data/view/D90393 EMBL M74924 http://www.ebi.ac.uk/ena/data/view/M74924 EMBL M81433 http://www.ebi.ac.uk/ena/data/view/M81433 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X59307 http://www.ebi.ac.uk/ena/data/view/X59307 EchoBASE EB0724 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0724 EcoGene EG10731 http://www.ecogene.org/geneInfo.php?eg_id=EG10731 EnsemblBacteria AAC74214 http://www.ensemblgenomes.org/id/AAC74214 EnsemblBacteria AAC74214 http://www.ensemblgenomes.org/id/AAC74214 EnsemblBacteria BAA35952 http://www.ensemblgenomes.org/id/BAA35952 EnsemblBacteria BAA35952 http://www.ensemblgenomes.org/id/BAA35952 EnsemblBacteria BAA35952 http://www.ensemblgenomes.org/id/BAA35952 EnsemblBacteria b1130 http://www.ensemblgenomes.org/id/b1130 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 945697 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945697 HOGENOM HOG000034815 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000034815&db=HOGENOM6 InParanoid P23836 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23836 IntAct P23836 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P23836* InterPro IPR001789 http://www.ebi.ac.uk/interpro/entry/IPR001789 InterPro IPR001867 http://www.ebi.ac.uk/interpro/entry/IPR001867 InterPro IPR011006 http://www.ebi.ac.uk/interpro/entry/IPR011006 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW1116 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1116 KEGG_Gene eco:b1130 http://www.genome.jp/dbget-bin/www_bget?eco:b1130 KEGG_Orthology KO:K07660 http://www.genome.jp/dbget-bin/www_bget?KO:K07660 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA LFNERCT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LFNERCT PDB 2PKX http://www.ebi.ac.uk/pdbe-srv/view/entry/2PKX PDB 2PL1 http://www.ebi.ac.uk/pdbe-srv/view/entry/2PL1 PDBsum 2PKX http://www.ebi.ac.uk/pdbsum/2PKX PDBsum 2PL1 http://www.ebi.ac.uk/pdbsum/2PL1 PROSITE PS50110 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50110 PROSITE PS51755 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51755 PSORT swissprot:PHOP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PHOP_ECOLI PSORT-B swissprot:PHOP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PHOP_ECOLI PSORT2 swissprot:PHOP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PHOP_ECOLI Pfam PF00072 http://pfam.xfam.org/family/PF00072 Pfam PF00486 http://pfam.xfam.org/family/PF00486 Phobius swissprot:PHOP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PHOP_ECOLI PhylomeDB P23836 http://phylomedb.org/?seqid=P23836 ProteinModelPortal P23836 http://www.proteinmodelportal.org/query/uniprot/P23836 PubMed 10464230 http://www.ncbi.nlm.nih.gov/pubmed/10464230 PubMed 12123454 http://www.ncbi.nlm.nih.gov/pubmed/12123454 PubMed 12813061 http://www.ncbi.nlm.nih.gov/pubmed/12813061 PubMed 13129944 http://www.ncbi.nlm.nih.gov/pubmed/13129944 PubMed 15126461 http://www.ncbi.nlm.nih.gov/pubmed/15126461 PubMed 1530848 http://www.ncbi.nlm.nih.gov/pubmed/1530848 PubMed 15703297 http://www.ncbi.nlm.nih.gov/pubmed/15703297 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1729205 http://www.ncbi.nlm.nih.gov/pubmed/1729205 PubMed 1729240 http://www.ncbi.nlm.nih.gov/pubmed/1729240 PubMed 17545283 http://www.ncbi.nlm.nih.gov/pubmed/17545283 PubMed 20041203 http://www.ncbi.nlm.nih.gov/pubmed/20041203 PubMed 22267510 http://www.ncbi.nlm.nih.gov/pubmed/22267510 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_415648 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415648 RefSeq WP_001265471 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001265471 SMART SM00448 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00448 SMART SM00862 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00862 SMR P23836 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P23836 STRING 511145.b1130 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1130&targetmode=cogs STRING COG0745 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0745&targetmode=cogs SUPFAM SSF52172 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52172 UniProtKB PHOP_ECOLI http://www.uniprot.org/uniprot/PHOP_ECOLI UniProtKB-AC P23836 http://www.uniprot.org/uniprot/P23836 charge swissprot:PHOP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PHOP_ECOLI eggNOG ENOG4105XJC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105XJC eggNOG ENOG4111FPD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111FPD epestfind swissprot:PHOP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PHOP_ECOLI garnier swissprot:PHOP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PHOP_ECOLI helixturnhelix swissprot:PHOP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PHOP_ECOLI hmoment swissprot:PHOP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PHOP_ECOLI iep swissprot:PHOP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PHOP_ECOLI inforesidue swissprot:PHOP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PHOP_ECOLI octanol swissprot:PHOP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PHOP_ECOLI pepcoil swissprot:PHOP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PHOP_ECOLI pepdigest swissprot:PHOP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PHOP_ECOLI pepinfo swissprot:PHOP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PHOP_ECOLI pepnet swissprot:PHOP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PHOP_ECOLI pepstats swissprot:PHOP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PHOP_ECOLI pepwheel swissprot:PHOP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PHOP_ECOLI pepwindow swissprot:PHOP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PHOP_ECOLI sigcleave swissprot:PHOP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PHOP_ECOLI ## Database ID URL or Descriptions # BioGrid 4261315 141 # EcoGene EG13466 yphE # FUNCTION YPHE_ECOLI Probably part of a binding-protein-dependent transport system YphDEF. Probably responsible for energy coupling to the transport system. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016887 ATPase activity; IEA:InterPro. # GO_process GO:0006810 transport; IEA:UniProtKB-KW. # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # Gene3D 3.40.50.300 -; 2. # IntAct P77509 7 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00221 Putative simple sugar transport system # KEGG_Brite ko02000 Transporters # Organism YPHE_ECOLI Escherichia coli (strain K12) # PATRIC 32120491 VBIEscCol129921_2648 # PIR B65032 B65032 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2; 2 # Pfam PF00005 ABC_tran; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YPHE_ECOLI Uncharacterized ABC transporter ATP-binding protein YphE # RefSeq NP_417042 NC_000913.3 # RefSeq WP_000493470 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. {ECO 0000305}. # SIMILARITY Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA; 2 # SUPFAM SSF52540 SSF52540; 2 # TCDB 3.A.1.2.27 the atp-binding cassette (abc) superfamily # eggNOG COG1129 LUCA # eggNOG ENOG4108F37 Bacteria BLAST swissprot:YPHE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YPHE_ECOLI BioCyc ECOL316407:JW2531-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2531-MONOMER BioCyc EcoCyc:YPHE-MONOMER http://biocyc.org/getid?id=EcoCyc:YPHE-MONOMER COG COG1129 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1129 COG COG3845 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3845 DIP DIP-12830N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12830N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3239 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3239 EcoGene EG13466 http://www.ecogene.org/geneInfo.php?eg_id=EG13466 EnsemblBacteria AAC75600 http://www.ensemblgenomes.org/id/AAC75600 EnsemblBacteria AAC75600 http://www.ensemblgenomes.org/id/AAC75600 EnsemblBacteria BAA16449 http://www.ensemblgenomes.org/id/BAA16449 EnsemblBacteria BAA16449 http://www.ensemblgenomes.org/id/BAA16449 EnsemblBacteria BAA16449 http://www.ensemblgenomes.org/id/BAA16449 EnsemblBacteria b2547 http://www.ensemblgenomes.org/id/b2547 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948990 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948990 InParanoid P77509 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77509 IntAct P77509 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77509* InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2531 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2531 KEGG_Gene eco:b2547 http://www.genome.jp/dbget-bin/www_bget?eco:b2547 KEGG_Orthology KO:K02056 http://www.genome.jp/dbget-bin/www_bget?KO:K02056 OMA NEISPAN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NEISPAN PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:YPHE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YPHE_ECOLI PSORT-B swissprot:YPHE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YPHE_ECOLI PSORT2 swissprot:YPHE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YPHE_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Phobius swissprot:YPHE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YPHE_ECOLI PhylomeDB P77509 http://phylomedb.org/?seqid=P77509 ProteinModelPortal P77509 http://www.proteinmodelportal.org/query/uniprot/P77509 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417042 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417042 RefSeq WP_000493470 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000493470 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 STRING 511145.b2547 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2547&targetmode=cogs STRING COG1129 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1129&targetmode=cogs STRING COG3845 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3845&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.2.27 http://www.tcdb.org/search/result.php?tc=3.A.1.2.27 UniProtKB YPHE_ECOLI http://www.uniprot.org/uniprot/YPHE_ECOLI UniProtKB-AC P77509 http://www.uniprot.org/uniprot/P77509 charge swissprot:YPHE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YPHE_ECOLI eggNOG COG1129 http://eggnogapi.embl.de/nog_data/html/tree/COG1129 eggNOG ENOG4108F37 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108F37 epestfind swissprot:YPHE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YPHE_ECOLI garnier swissprot:YPHE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YPHE_ECOLI helixturnhelix swissprot:YPHE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YPHE_ECOLI hmoment swissprot:YPHE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YPHE_ECOLI iep swissprot:YPHE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YPHE_ECOLI inforesidue swissprot:YPHE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YPHE_ECOLI octanol swissprot:YPHE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YPHE_ECOLI pepcoil swissprot:YPHE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YPHE_ECOLI pepdigest swissprot:YPHE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YPHE_ECOLI pepinfo swissprot:YPHE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YPHE_ECOLI pepnet swissprot:YPHE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YPHE_ECOLI pepstats swissprot:YPHE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YPHE_ECOLI pepwheel swissprot:YPHE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YPHE_ECOLI pepwindow swissprot:YPHE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YPHE_ECOLI sigcleave swissprot:YPHE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YPHE_ECOLI ## Database ID URL or Descriptions # DISRUPTION PHENOTYPE None seen. {ECO:0000269|PubMed 18710431}. # EcoGene EG14472 ibsA # FUNCTION IBSA_ECOLI May be a toxic protein; overexpression causes cessation of growth. {ECO 0000269|PubMed 18710431}. # GO_process GO:0012501 programmed cell death; IMP:EcoCyc. # GOslim_process GO:0008219 cell death # INDUCTION The sibA sRNA probably represses expression of ibsA mRNA, either by destabilizing the transcript and/or preventing its translation. A type I toxin antitoxin (TA) system, where expression of the proteinaceous toxin is controlled by an antisense sRNA. {ECO:0000269|PubMed 18710431}. # InterPro IPR025881 Toxin_Ibs # MISCELLANEOUS IBSA_ECOLI Part of the SIBa repeat region (formerly known as QUAD1a), encoded on the opposite strand from the sibA (formerly known as ryeC) RNA. # Organism IBSA_ECOLI Escherichia coli (strain K12) # Pfam PF13956 Ibs_toxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName IBSA_ECOLI Small toxic protein IbsA # RefSeq YP_002791247 NC_000913.3 # SIMILARITY Belongs to the toxic protein ibs family. {ECO 0000305}. BLAST swissprot:IBSA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:IBSA_ECOLI BioCyc EcoCyc:MONOMER0-2859 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2859 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2008.06394.x http://dx.doi.org/10.1111/j.1365-2958.2008.06394.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14472 http://www.ecogene.org/geneInfo.php?eg_id=EG14472 EnsemblBacteria ACO59999 http://www.ensemblgenomes.org/id/ACO59999 EnsemblBacteria ACO59999 http://www.ensemblgenomes.org/id/ACO59999 EnsemblBacteria b4667 http://www.ensemblgenomes.org/id/b4667 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0012501 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0012501 GOslim_process GO:0008219 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008219 GeneID 7751625 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7751625 InterPro IPR025881 http://www.ebi.ac.uk/interpro/entry/IPR025881 KEGG_Gene eco:b4667 http://www.genome.jp/dbget-bin/www_bget?eco:b4667 PSORT swissprot:IBSA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:IBSA_ECOLI PSORT-B swissprot:IBSA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:IBSA_ECOLI PSORT2 swissprot:IBSA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:IBSA_ECOLI Pfam PF13956 http://pfam.xfam.org/family/PF13956 Phobius swissprot:IBSA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:IBSA_ECOLI PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18710431 http://www.ncbi.nlm.nih.gov/pubmed/18710431 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq YP_002791247 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_002791247 STRING 511145.b4667 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4667&targetmode=cogs UniProtKB IBSA_ECOLI http://www.uniprot.org/uniprot/IBSA_ECOLI UniProtKB-AC C1P607 http://www.uniprot.org/uniprot/C1P607 charge swissprot:IBSA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:IBSA_ECOLI epestfind swissprot:IBSA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:IBSA_ECOLI garnier swissprot:IBSA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:IBSA_ECOLI helixturnhelix swissprot:IBSA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:IBSA_ECOLI hmoment swissprot:IBSA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:IBSA_ECOLI iep swissprot:IBSA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:IBSA_ECOLI inforesidue swissprot:IBSA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:IBSA_ECOLI octanol swissprot:IBSA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:IBSA_ECOLI pepcoil swissprot:IBSA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:IBSA_ECOLI pepdigest swissprot:IBSA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:IBSA_ECOLI pepinfo swissprot:IBSA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:IBSA_ECOLI pepnet swissprot:IBSA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:IBSA_ECOLI pepstats swissprot:IBSA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:IBSA_ECOLI pepwheel swissprot:IBSA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:IBSA_ECOLI pepwindow swissprot:IBSA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:IBSA_ECOLI sigcleave swissprot:IBSA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:IBSA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262326 69 # EcoGene EG13062 ssnA # GO_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; IEA:InterPro. # GO_function GO:0019239 deaminase activity; IBA:GO_Central. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_function GO:0043167 ion binding # Gene3D 2.30.40.10 -; 2. # INDUCTION SSNA_ECOLI In stationary phase. # IntAct Q46812 4 # InterPro IPR006680 Amidohydro-rel # InterPro IPR011059 Metal-dep_hydrolase_composite # InterPro IPR017700 Se_metab_SsnA # InterPro IPR032466 Metal_Hydrolase # Organism SSNA_ECOLI Escherichia coli (strain K12) # PATRIC 32121168 VBIEscCol129921_2972 # PIR G65071 G65071 # Pfam PF01979 Amidohydro_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SSNA_ECOLI Protein SsnA # RefSeq NP_417355 NC_000913.3 # RefSeq WP_000906252 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA83060.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ATZ/TRZ family. {ECO 0000305}. # SUPFAM SSF51338 SSF51338; 2 # SUPFAM SSF51556 SSF51556 # TIGRFAMs TIGR03314 Se_ssnA # eggNOG COG0402 LUCA # eggNOG ENOG4107UUR Bacteria BLAST swissprot:SSNA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SSNA_ECOLI BioCyc ECOL316407:JW2847-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2847-MONOMER BioCyc EcoCyc:G7498-MONOMER http://biocyc.org/getid?id=EcoCyc:G7498-MONOMER DIP DIP-10923N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10923N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1271/bbb.58.117 http://dx.doi.org/10.1271/bbb.58.117 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D21141 http://www.ebi.ac.uk/ena/data/view/D21141 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 EchoBASE EB2874 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2874 EcoGene EG13062 http://www.ecogene.org/geneInfo.php?eg_id=EG13062 EnsemblBacteria AAC75917 http://www.ensemblgenomes.org/id/AAC75917 EnsemblBacteria AAC75917 http://www.ensemblgenomes.org/id/AAC75917 EnsemblBacteria BAE76945 http://www.ensemblgenomes.org/id/BAE76945 EnsemblBacteria BAE76945 http://www.ensemblgenomes.org/id/BAE76945 EnsemblBacteria BAE76945 http://www.ensemblgenomes.org/id/BAE76945 EnsemblBacteria b2879 http://www.ensemblgenomes.org/id/b2879 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GO_function GO:0019239 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019239 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 2.30.40.10 http://www.cathdb.info/version/latest/superfamily/2.30.40.10 GeneID 949072 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949072 HOGENOM HOG000250646 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000250646&db=HOGENOM6 InParanoid Q46812 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46812 IntAct Q46812 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46812* InterPro IPR006680 http://www.ebi.ac.uk/interpro/entry/IPR006680 InterPro IPR011059 http://www.ebi.ac.uk/interpro/entry/IPR011059 InterPro IPR017700 http://www.ebi.ac.uk/interpro/entry/IPR017700 InterPro IPR032466 http://www.ebi.ac.uk/interpro/entry/IPR032466 KEGG_Gene ecj:JW2847 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2847 KEGG_Gene eco:b2879 http://www.genome.jp/dbget-bin/www_bget?eco:b2879 OMA HTPRANQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HTPRANQ PSORT swissprot:SSNA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SSNA_ECOLI PSORT-B swissprot:SSNA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SSNA_ECOLI PSORT2 swissprot:SSNA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SSNA_ECOLI Pfam PF01979 http://pfam.xfam.org/family/PF01979 Phobius swissprot:SSNA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SSNA_ECOLI PhylomeDB Q46812 http://phylomedb.org/?seqid=Q46812 ProteinModelPortal Q46812 http://www.proteinmodelportal.org/query/uniprot/Q46812 PubMed 10074077 http://www.ncbi.nlm.nih.gov/pubmed/10074077 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7764507 http://www.ncbi.nlm.nih.gov/pubmed/7764507 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417355 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417355 RefSeq WP_000906252 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000906252 SMR Q46812 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46812 STRING 511145.b2879 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2879&targetmode=cogs SUPFAM SSF51338 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51338 SUPFAM SSF51556 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51556 TIGRFAMs TIGR03314 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03314 UniProtKB SSNA_ECOLI http://www.uniprot.org/uniprot/SSNA_ECOLI UniProtKB-AC Q46812 http://www.uniprot.org/uniprot/Q46812 charge swissprot:SSNA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SSNA_ECOLI eggNOG COG0402 http://eggnogapi.embl.de/nog_data/html/tree/COG0402 eggNOG ENOG4107UUR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107UUR epestfind swissprot:SSNA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SSNA_ECOLI garnier swissprot:SSNA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SSNA_ECOLI helixturnhelix swissprot:SSNA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SSNA_ECOLI hmoment swissprot:SSNA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SSNA_ECOLI iep swissprot:SSNA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SSNA_ECOLI inforesidue swissprot:SSNA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SSNA_ECOLI octanol swissprot:SSNA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SSNA_ECOLI pepcoil swissprot:SSNA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SSNA_ECOLI pepdigest swissprot:SSNA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SSNA_ECOLI pepinfo swissprot:SSNA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SSNA_ECOLI pepnet swissprot:SSNA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SSNA_ECOLI pepstats swissprot:SSNA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SSNA_ECOLI pepwheel swissprot:SSNA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SSNA_ECOLI pepwindow swissprot:SSNA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SSNA_ECOLI sigcleave swissprot:SSNA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SSNA_ECOLI ## Database ID URL or Descriptions # AltName LPTD_ECOLI Organic solvent tolerance protein # BioGrid 4259723 246 # DISRUPTION PHENOTYPE LPTD_ECOLI Mutations alter the permeability of the outer membrane resulting in increased sensitivity to detergents, antibiotics and dyes. Depletion leads to filamentation followed by membrane rupture and cell lysis. {ECO 0000269|PubMed 12207697, ECO 0000269|PubMed 2547691}. # DOMAIN LPTD_ECOLI Contains an N-terminal soluble domain that is likely periplasmic and interacts with LptA, and a C-terminal transmembrane domain, which is predicted to be a beta-barrel and interacts with LptE. Residues 529-538 play a key role in interaction with LptE. {ECO 0000269|PubMed 20203010, ECO 0000269|PubMed 21257904, ECO 0000269|PubMed 22668317}. # EcoGene EG11569 lptD # FUNCTION LPTD_ECOLI Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Contributes to n-hexane resistance. {ECO 0000255|HAMAP- Rule MF_01411, ECO 0000269|PubMed 12207697, ECO 0000269|PubMed 12724388, ECO 0000269|PubMed 16861298, ECO 0000269|PubMed 18424520, ECO 0000269|PubMed 20203010, ECO 0000269|PubMed 21339611, ECO 0000269|PubMed 2547691, ECO 0000269|PubMed 7811102}. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_process GO:0010033 response to organic substance; IEA:InterPro. # GO_process GO:0015920 lipopolysaccharide transport; IMP:EcoliWiki. # GO_process GO:0043165 Gram-negative-bacterium-type cell outer membrane assembly; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0061024 membrane organization # HAMAP MF_01411 LPS_assembly_LptD # INDUCTION Constitutively expressed. {ECO:0000269|PubMed 14981317}. # INTERACTION LPTD_ECOLI P0ADV1 lptA; NbExp=3; IntAct=EBI-549369, EBI-1132001; P0ADC1 lptE; NbExp=3; IntAct=EBI-549369, EBI-1119442; # IntAct P31554 8 # InterPro IPR005653 OstA-like_N # InterPro IPR007543 OstA_C # InterPro IPR020889 LipoPS_assembly_LptD # KEGG_Brite ko02000 Transporters # MISCELLANEOUS LPTD_ECOLI The correct assembly of LptD depends on the thiol disulfide interchange proteins DsbA and DsbC, the chaperone proteins SurA and Skp, LptE and the chaperone/protease BepA (PubMed 20615876, PubMed 20566849, PubMed 21257904, PubMed 21257909, PubMed 23772069, PubMed 24003122). BepA can also promote degradation of incorrectly folded LptD (PubMed 24003122). {ECO 0000305|PubMed 20566849, ECO 0000305|PubMed 20615876, ECO 0000305|PubMed 21257904, ECO 0000305|PubMed 21257909, ECO 0000305|PubMed 23772069, ECO 0000305|PubMed 24003122}. # Organism LPTD_ECOLI Escherichia coli (strain K12) # PATRIC 32115207 VBIEscCol129921_0055 # PDB 4RHB X-ray; 3.35 A; A/C=203-784 # PIR F64726 F64726 # PTM LPTD_ECOLI Contains two intramolecular disulfide bonds. At least one disulfide bond is required for activity, and protein is probably fully oxidized in vivo. # Pfam PF03968 OstA # Pfam PF04453 OstA_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LPS-assembly protein LptD {ECO:0000255|HAMAP-Rule MF_01411} # RefSeq NP_414596 NC_000913.3 # RefSeq WP_000746151 NZ_LN832404.1 # SIMILARITY Belongs to the LptD family. {ECO:0000255|HAMAP- Rule MF_01411}. # SUBCELLULAR LOCATION LPTD_ECOLI Cell outer membrane {ECO 0000255|HAMAP- Rule MF_01411, ECO 0000269|PubMed 12207697, ECO 0000269|PubMed 12724388, ECO 0000269|PubMed 16079137, ECO 0000269|PubMed 20446753}. # SUBUNIT LPTD_ECOLI Component of the lipopolysaccharide transport and assembly complex. Interacts with LptE and LptA. May interact with LptE during assembly of LptD by the beta-barrel assembly machine. {ECO 0000255|HAMAP-Rule MF_01411, ECO 0000269|PubMed 16079137, ECO 0000269|PubMed 16861298, ECO 0000269|PubMed 20203010, ECO 0000269|PubMed 21257904, ECO 0000269|PubMed 21257909, ECO 0000269|PubMed 22668317}. # TCDB 1.B.42.1 the outer membrane lipopolysaccharide export porin (lps-ep) family # eggNOG COG1452 LUCA # eggNOG ENOG4105E7H Bacteria BLAST swissprot:LPTD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LPTD_ECOLI BioCyc ECOL316407:JW0053-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0053-MONOMER BioCyc EcoCyc:EG11569-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11569-MONOMER BioCyc MetaCyc:EG11569-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11569-MONOMER COG COG1452 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1452 DIP DIP-10029N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10029N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1021/bi100493e http://dx.doi.org/10.1021/bi100493e DOI 10.1021/bi300592c http://dx.doi.org/10.1021/bi300592c DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2002.03091.x http://dx.doi.org/10.1046/j.1365-2958.2002.03091.x DOI 10.1073/pnas.0604744103 http://dx.doi.org/10.1073/pnas.0604744103 DOI 10.1073/pnas.0912872107 http://dx.doi.org/10.1073/pnas.0912872107 DOI 10.1073/pnas.1007319107 http://dx.doi.org/10.1073/pnas.1007319107 DOI 10.1073/pnas.1015617108 http://dx.doi.org/10.1073/pnas.1015617108 DOI 10.1073/pnas.1019089108 http://dx.doi.org/10.1073/pnas.1019089108 DOI 10.1073/pnas.1312012110 http://dx.doi.org/10.1073/pnas.1312012110 DOI 10.1074/jbc.M110.119321 http://dx.doi.org/10.1074/jbc.M110.119321 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1088/0953-8984/22/45/454124 http://dx.doi.org/10.1088/0953-8984/22/45/454124 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1099/mic.0.25927-0 http://dx.doi.org/10.1099/mic.0.25927-0 DOI 10.1126/science.1227215 http://dx.doi.org/10.1126/science.1227215 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00270-08 http://dx.doi.org/10.1128/JB.00270-08 DOI 10.1128/JB.00431-13 http://dx.doi.org/10.1128/JB.00431-13 DOI 10.1271/bbb.68.458 http://dx.doi.org/10.1271/bbb.68.458 EMBL AB013134 http://www.ebi.ac.uk/ena/data/view/AB013134 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1529 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1529 EcoGene EG11569 http://www.ecogene.org/geneInfo.php?eg_id=EG11569 EnsemblBacteria AAC73165 http://www.ensemblgenomes.org/id/AAC73165 EnsemblBacteria AAC73165 http://www.ensemblgenomes.org/id/AAC73165 EnsemblBacteria BAB96622 http://www.ensemblgenomes.org/id/BAB96622 EnsemblBacteria BAB96622 http://www.ensemblgenomes.org/id/BAB96622 EnsemblBacteria BAB96622 http://www.ensemblgenomes.org/id/BAB96622 EnsemblBacteria b0054 http://www.ensemblgenomes.org/id/b0054 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_process GO:0010033 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010033 GO_process GO:0015920 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015920 GO_process GO:0043165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043165 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0061024 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024 GeneID 945011 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945011 HAMAP MF_01411 http://hamap.expasy.org/unirule/MF_01411 HOGENOM HOG000218450 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218450&db=HOGENOM6 InParanoid P31554 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31554 IntAct P31554 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31554* InterPro IPR005653 http://www.ebi.ac.uk/interpro/entry/IPR005653 InterPro IPR007543 http://www.ebi.ac.uk/interpro/entry/IPR007543 InterPro IPR020889 http://www.ebi.ac.uk/interpro/entry/IPR020889 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0053 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0053 KEGG_Gene eco:b0054 http://www.genome.jp/dbget-bin/www_bget?eco:b0054 KEGG_Orthology KO:K04744 http://www.genome.jp/dbget-bin/www_bget?KO:K04744 MINT MINT-1293333 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1293333 OMA DYSHLDW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DYSHLDW PDB 4RHB http://www.ebi.ac.uk/pdbe-srv/view/entry/4RHB PDBsum 4RHB http://www.ebi.ac.uk/pdbsum/4RHB PSORT swissprot:LPTD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LPTD_ECOLI PSORT-B swissprot:LPTD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LPTD_ECOLI PSORT2 swissprot:LPTD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LPTD_ECOLI Pfam PF03968 http://pfam.xfam.org/family/PF03968 Pfam PF04453 http://pfam.xfam.org/family/PF04453 Phobius swissprot:LPTD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LPTD_ECOLI PhylomeDB P31554 http://phylomedb.org/?seqid=P31554 ProteinModelPortal P31554 http://www.proteinmodelportal.org/query/uniprot/P31554 PubMed 12207697 http://www.ncbi.nlm.nih.gov/pubmed/12207697 PubMed 12724388 http://www.ncbi.nlm.nih.gov/pubmed/12724388 PubMed 14981317 http://www.ncbi.nlm.nih.gov/pubmed/14981317 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16861298 http://www.ncbi.nlm.nih.gov/pubmed/16861298 PubMed 18424520 http://www.ncbi.nlm.nih.gov/pubmed/18424520 PubMed 20203010 http://www.ncbi.nlm.nih.gov/pubmed/20203010 PubMed 20446753 http://www.ncbi.nlm.nih.gov/pubmed/20446753 PubMed 20566849 http://www.ncbi.nlm.nih.gov/pubmed/20566849 PubMed 20615876 http://www.ncbi.nlm.nih.gov/pubmed/20615876 PubMed 21257904 http://www.ncbi.nlm.nih.gov/pubmed/21257904 PubMed 21257909 http://www.ncbi.nlm.nih.gov/pubmed/21257909 PubMed 21339611 http://www.ncbi.nlm.nih.gov/pubmed/21339611 PubMed 22668317 http://www.ncbi.nlm.nih.gov/pubmed/22668317 PubMed 22936569 http://www.ncbi.nlm.nih.gov/pubmed/22936569 PubMed 23772069 http://www.ncbi.nlm.nih.gov/pubmed/23772069 PubMed 24003122 http://www.ncbi.nlm.nih.gov/pubmed/24003122 PubMed 2547691 http://www.ncbi.nlm.nih.gov/pubmed/2547691 PubMed 7811102 http://www.ncbi.nlm.nih.gov/pubmed/7811102 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_414596 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414596 RefSeq WP_000746151 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000746151 SMR P31554 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31554 STRING 511145.b0054 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0054&targetmode=cogs STRING COG1452 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1452&targetmode=cogs SWISS-2DPAGE P31554 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P31554 TCDB 1.B.42.1 http://www.tcdb.org/search/result.php?tc=1.B.42.1 UniProtKB LPTD_ECOLI http://www.uniprot.org/uniprot/LPTD_ECOLI UniProtKB-AC P31554 http://www.uniprot.org/uniprot/P31554 charge swissprot:LPTD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LPTD_ECOLI eggNOG COG1452 http://eggnogapi.embl.de/nog_data/html/tree/COG1452 eggNOG ENOG4105E7H http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E7H epestfind swissprot:LPTD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LPTD_ECOLI garnier swissprot:LPTD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LPTD_ECOLI helixturnhelix swissprot:LPTD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LPTD_ECOLI hmoment swissprot:LPTD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LPTD_ECOLI iep swissprot:LPTD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LPTD_ECOLI inforesidue swissprot:LPTD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LPTD_ECOLI octanol swissprot:LPTD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LPTD_ECOLI pepcoil swissprot:LPTD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LPTD_ECOLI pepdigest swissprot:LPTD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LPTD_ECOLI pepinfo swissprot:LPTD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LPTD_ECOLI pepnet swissprot:LPTD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LPTD_ECOLI pepstats swissprot:LPTD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LPTD_ECOLI pepwheel swissprot:LPTD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LPTD_ECOLI pepwindow swissprot:LPTD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LPTD_ECOLI sigcleave swissprot:LPTD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LPTD_ECOLI ## Database ID URL or Descriptions # AltName CYSN_ECOLI ATP-sulfurylase large subunit # AltName CYSN_ECOLI Sulfate adenylate transferase # BioGrid 4262932 18 # CATALYTIC ACTIVITY CYSN_ECOLI ATP + sulfate = diphosphate + adenylyl sulfate. # ENZYME REGULATION CYSN_ECOLI GTPase activity is coupled to stimulation of the rate of APS formation. # EcoGene EG10194 cysN # FUNCTION CYSN_ECOLI May be the GTPase, regulating ATP sulfurylase activity. # GO_component GO:0005622 intracellular; IBA:GO_Central. # GO_function GO:0003924 GTPase activity; IDA:EcoliWiki. # GO_function GO:0004781 sulfate adenylyltransferase (ATP) activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0005525 GTP binding; ISS:EcoliWiki. # GO_process GO:0000103 sulfate assimilation; IEA:UniProtKB-HAMAP. # GO_process GO:0006790 sulfur compound metabolic process; IMP:EcoliWiki. # GO_process GO:0070814 hydrogen sulfide biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005622 intracellular # GOslim_function GO:0003924 GTPase activity # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.300 -; 1. # HAMAP MF_00062 Sulf_adenylyltr_sub1 # IntAct P23845 3 # InterPro IPR000795 TF_GTP-bd_dom # InterPro IPR005225 Small_GTP-bd_dom # InterPro IPR009000 Transl_B-barrel # InterPro IPR009001 Transl_elong_EF1A/Init_IF2_C # InterPro IPR011779 SO4_adenylTrfase_lsu # InterPro IPR027417 P-loop_NTPase # InterPro IPR031157 G_TR_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00450 Selenocompound metabolism # KEGG_Pathway ko00920 Sulfur metabolism # Organism CYSN_ECOLI Escherichia coli (strain K12) # PATHWAY Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate step 1/3. # PATRIC 32120908 VBIEscCol129921_2846 # PIR JN0327 JN0327 # PRINTS PR00315 ELONGATNFCT # PROSITE PS00301 G_TR_1 # PROSITE PS51722 G_TR_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CYSN_ECOLI Sulfate adenylyltransferase subunit 1 # RefSeq NP_417231 NC_000913.3 # RefSeq WP_001090361 NZ_LN832404.1 # SIMILARITY Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. {ECO 0000305}. # SIMILARITY Contains 1 tr-type G (guanine nucleotide-binding) domain. {ECO 0000305}. # SUBUNIT CYSN_ECOLI Heterodimer composed of CysD, the smaller subunit, and CysN. # SUPFAM SSF50447 SSF50447 # SUPFAM SSF50465 SSF50465 # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR00231 small_GTP # TIGRFAMs TIGR02034 CysN # UniPathway UPA00140 UER00204 # eggNOG COG2895 LUCA # eggNOG ENOG4105C3T Bacteria BLAST swissprot:CYSN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CYSN_ECOLI BioCyc ECOL316407:JW2721-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2721-MONOMER BioCyc EcoCyc:CYSN-MONOMER http://biocyc.org/getid?id=EcoCyc:CYSN-MONOMER BioCyc MetaCyc:CYSN-MONOMER http://biocyc.org/getid?id=MetaCyc:CYSN-MONOMER COG COG2895 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2895 DIP DIP-513N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-513N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.7.4 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.4 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M74586 http://www.ebi.ac.uk/ena/data/view/M74586 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 ENZYME 2.7.7.4 http://enzyme.expasy.org/EC/2.7.7.4 EchoBASE EB0191 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0191 EcoGene EG10194 http://www.ecogene.org/geneInfo.php?eg_id=EG10194 EnsemblBacteria AAC75793 http://www.ensemblgenomes.org/id/AAC75793 EnsemblBacteria AAC75793 http://www.ensemblgenomes.org/id/AAC75793 EnsemblBacteria BAE76828 http://www.ensemblgenomes.org/id/BAE76828 EnsemblBacteria BAE76828 http://www.ensemblgenomes.org/id/BAE76828 EnsemblBacteria BAE76828 http://www.ensemblgenomes.org/id/BAE76828 EnsemblBacteria b2751 http://www.ensemblgenomes.org/id/b2751 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GO_function GO:0004781 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004781 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_process GO:0000103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000103 GO_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GO_process GO:0070814 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070814 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947219 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947219 HAMAP MF_00062 http://hamap.expasy.org/unirule/MF_00062 HOGENOM HOG000229289 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000229289&db=HOGENOM6 InParanoid P23845 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23845 IntAct P23845 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P23845* IntEnz 2.7.7.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.4 InterPro IPR000795 http://www.ebi.ac.uk/interpro/entry/IPR000795 InterPro IPR005225 http://www.ebi.ac.uk/interpro/entry/IPR005225 InterPro IPR009000 http://www.ebi.ac.uk/interpro/entry/IPR009000 InterPro IPR009001 http://www.ebi.ac.uk/interpro/entry/IPR009001 InterPro IPR011779 http://www.ebi.ac.uk/interpro/entry/IPR011779 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR031157 http://www.ebi.ac.uk/interpro/entry/IPR031157 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2721 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2721 KEGG_Gene eco:b2751 http://www.genome.jp/dbget-bin/www_bget?eco:b2751 KEGG_Orthology KO:K00956 http://www.genome.jp/dbget-bin/www_bget?KO:K00956 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00450 http://www.genome.jp/kegg-bin/show_pathway?ko00450 KEGG_Pathway ko00920 http://www.genome.jp/kegg-bin/show_pathway?ko00920 KEGG_Reaction rn:R00529 http://www.genome.jp/dbget-bin/www_bget?rn:R00529 KEGG_Reaction rn:R04929 http://www.genome.jp/dbget-bin/www_bget?rn:R04929 MINT MINT-1247685 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1247685 OMA FAANIVW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FAANIVW PRINTS PR00315 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00315 PROSITE PS00301 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00301 PROSITE PS51722 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51722 PSORT swissprot:CYSN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CYSN_ECOLI PSORT-B swissprot:CYSN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CYSN_ECOLI PSORT2 swissprot:CYSN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CYSN_ECOLI Phobius swissprot:CYSN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CYSN_ECOLI PhylomeDB P23845 http://phylomedb.org/?seqid=P23845 ProteinModelPortal P23845 http://www.proteinmodelportal.org/query/uniprot/P23845 PubMed 1316900 http://www.ncbi.nlm.nih.gov/pubmed/1316900 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2828368 http://www.ncbi.nlm.nih.gov/pubmed/2828368 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417231 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417231 RefSeq WP_001090361 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001090361 SMR P23845 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P23845 STRING 511145.b2751 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2751&targetmode=cogs STRING COG2895 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2895&targetmode=cogs SUPFAM SSF50447 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50447 SUPFAM SSF50465 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50465 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR00231 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00231 TIGRFAMs TIGR02034 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02034 UniProtKB CYSN_ECOLI http://www.uniprot.org/uniprot/CYSN_ECOLI UniProtKB-AC P23845 http://www.uniprot.org/uniprot/P23845 charge swissprot:CYSN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CYSN_ECOLI eggNOG COG2895 http://eggnogapi.embl.de/nog_data/html/tree/COG2895 eggNOG ENOG4105C3T http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C3T epestfind swissprot:CYSN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CYSN_ECOLI garnier swissprot:CYSN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CYSN_ECOLI helixturnhelix swissprot:CYSN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CYSN_ECOLI hmoment swissprot:CYSN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CYSN_ECOLI iep swissprot:CYSN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CYSN_ECOLI inforesidue swissprot:CYSN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CYSN_ECOLI octanol swissprot:CYSN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CYSN_ECOLI pepcoil swissprot:CYSN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CYSN_ECOLI pepdigest swissprot:CYSN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CYSN_ECOLI pepinfo swissprot:CYSN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CYSN_ECOLI pepnet swissprot:CYSN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CYSN_ECOLI pepstats swissprot:CYSN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CYSN_ECOLI pepwheel swissprot:CYSN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CYSN_ECOLI pepwindow swissprot:CYSN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CYSN_ECOLI sigcleave swissprot:CYSN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CYSN_ECOLI ## Database ID URL or Descriptions # BioGrid 4260044 6 # EcoGene EG10470 hyaC # FUNCTION CYBH_ECOLI Probable b-type cytochrome. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0044569 [Ni-Fe] hydrogenase complex; IDA:EcoCyc. # GO_function GO:0005506 iron ion binding; IEA:InterPro. # GO_function GO:0009055 electron carrier activity; IEA:InterPro. # GO_function GO:0020037 heme binding; IDA:EcoCyc. # GO_process GO:0006113 fermentation; IEP:EcoCyc. # GO_process GO:0006810 transport; IEA:InterPro. # GO_process GO:0009061 anaerobic respiration; IEP:EcoCyc. # GO_process GO:0022904 respiratory electron transport chain; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0006810 transport # InterPro IPR000516 Ni-dep_Hydgase_cyt-B # InterPro IPR011577 Cyt_b561_bac/Ni-Hgenase # InterPro IPR016174 Di-haem_cyt_TM # Organism CYBH_ECOLI Escherichia coli (strain K12) # PATRIC 32117169 VBIEscCol129921_1008 # PDB 4GD3 X-ray; 3.30 A; A/B=1-235 # PIR JV0074 BVECYC # PRINTS PR00161 NIHGNASECYTB # PROSITE PS00882 NI_HGENASE_CYTB_1 # PROSITE PS00883 NI_HGENASE_CYTB_2 # Pfam PF01292 Ni_hydr_CYTB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CYBH_ECOLI Probable Ni/Fe-hydrogenase 1 B-type cytochrome subunit # RefSeq NP_415493 NC_000913.3 # RefSeq WP_001186424 NZ_LN832404.1 # SIMILARITY Belongs to the HupC/HyaC/HydC family. {ECO 0000305}. # SUBCELLULAR LOCATION CYBH_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF81342 SSF81342 # TIGRFAMs TIGR02125 CytB-hydogenase # eggNOG COG1969 LUCA # eggNOG ENOG4105X7T Bacteria BLAST swissprot:CYBH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CYBH_ECOLI BioCyc ECOL316407:JW0956-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0956-MONOMER BioCyc EcoCyc:HYAC-MONOMER http://biocyc.org/getid?id=EcoCyc:HYAC-MONOMER BioCyc MetaCyc:HYAC-MONOMER http://biocyc.org/getid?id=MetaCyc:HYAC-MONOMER COG COG1969 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1969 DIP DIP-35859N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35859N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M34825 http://www.ebi.ac.uk/ena/data/view/M34825 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0465 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0465 EcoGene EG10470 http://www.ecogene.org/geneInfo.php?eg_id=EG10470 EnsemblBacteria AAC74059 http://www.ensemblgenomes.org/id/AAC74059 EnsemblBacteria AAC74059 http://www.ensemblgenomes.org/id/AAC74059 EnsemblBacteria BAA35739 http://www.ensemblgenomes.org/id/BAA35739 EnsemblBacteria BAA35739 http://www.ensemblgenomes.org/id/BAA35739 EnsemblBacteria BAA35739 http://www.ensemblgenomes.org/id/BAA35739 EnsemblBacteria b0974 http://www.ensemblgenomes.org/id/b0974 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0044569 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044569 GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0020037 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0020037 GO_process GO:0006113 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006113 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GO_process GO:0009061 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009061 GO_process GO:0022904 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022904 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 945581 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945581 HOGENOM HOG000291339 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000291339&db=HOGENOM6 InParanoid P0AAM1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAM1 IntAct P0AAM1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAM1* InterPro IPR000516 http://www.ebi.ac.uk/interpro/entry/IPR000516 InterPro IPR011577 http://www.ebi.ac.uk/interpro/entry/IPR011577 InterPro IPR016174 http://www.ebi.ac.uk/interpro/entry/IPR016174 KEGG_Gene ecj:JW0956 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0956 KEGG_Gene eco:b0974 http://www.genome.jp/dbget-bin/www_bget?eco:b0974 KEGG_Orthology KO:K03620 http://www.genome.jp/dbget-bin/www_bget?KO:K03620 OMA IITGYKH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IITGYKH PDB 4GD3 http://www.ebi.ac.uk/pdbe-srv/view/entry/4GD3 PDBsum 4GD3 http://www.ebi.ac.uk/pdbsum/4GD3 PRINTS PR00161 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00161 PROSITE PS00882 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00882 PROSITE PS00883 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00883 PSORT swissprot:CYBH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CYBH_ECOLI PSORT-B swissprot:CYBH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CYBH_ECOLI PSORT2 swissprot:CYBH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CYBH_ECOLI Pfam PF01292 http://pfam.xfam.org/family/PF01292 Phobius swissprot:CYBH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CYBH_ECOLI PhylomeDB P0AAM1 http://phylomedb.org/?seqid=P0AAM1 ProteinModelPortal P0AAM1 http://www.proteinmodelportal.org/query/uniprot/P0AAM1 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2180913 http://www.ncbi.nlm.nih.gov/pubmed/2180913 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415493 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415493 RefSeq WP_001186424 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001186424 SMR P0AAM1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAM1 STRING 511145.b0974 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0974&targetmode=cogs STRING COG1969 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1969&targetmode=cogs SUPFAM SSF81342 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81342 TIGRFAMs TIGR02125 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02125 UniProtKB CYBH_ECOLI http://www.uniprot.org/uniprot/CYBH_ECOLI UniProtKB-AC P0AAM1 http://www.uniprot.org/uniprot/P0AAM1 charge swissprot:CYBH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CYBH_ECOLI eggNOG COG1969 http://eggnogapi.embl.de/nog_data/html/tree/COG1969 eggNOG ENOG4105X7T http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105X7T epestfind swissprot:CYBH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CYBH_ECOLI garnier swissprot:CYBH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CYBH_ECOLI helixturnhelix swissprot:CYBH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CYBH_ECOLI hmoment swissprot:CYBH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CYBH_ECOLI iep swissprot:CYBH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CYBH_ECOLI inforesidue swissprot:CYBH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CYBH_ECOLI octanol swissprot:CYBH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CYBH_ECOLI pepcoil swissprot:CYBH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CYBH_ECOLI pepdigest swissprot:CYBH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CYBH_ECOLI pepinfo swissprot:CYBH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CYBH_ECOLI pepnet swissprot:CYBH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CYBH_ECOLI pepstats swissprot:CYBH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CYBH_ECOLI pepwheel swissprot:CYBH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CYBH_ECOLI pepwindow swissprot:CYBH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CYBH_ECOLI sigcleave swissprot:CYBH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CYBH_ECOLI ## Database ID URL or Descriptions # AltName ARSB_ECOLI Arsenic efflux pump protein # BioGrid 4261325 7 # CDD cd01118 ArsB_permease # EcoGene EG12236 arsB # FUNCTION ARSB_ECOLI Involved in arsenical resistance. Thought to form the channel of an arsenite pump (By similarity). {ECO 0000250}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoliWiki. # GO_function GO:0008490 arsenite secondary active transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0042960 antimonite secondary active transmembrane transporter activity; IDA:EcoCyc. # GO_process GO:0015699 antimonite transport; IDA:EcoCyc. # GO_process GO:0015700 arsenite transport; IDA:EcoCyc. # GO_process GO:0046685 response to arsenic-containing substance; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # InterPro IPR000802 Arsenical_pump_ArsB # KEGG_Brite ko02000 Transporters # Organism ARSB_ECOLI Escherichia coli (strain K12) # PATRIC 32122458 VBIEscCol129921_3606 # PIR S47723 S47723 # PRINTS PR00758 ARSENICPUMP # Pfam PF02040 ArsB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ARSB_ECOLI Arsenical pump membrane protein # RefSeq NP_417959 NC_000913.3 # RefSeq WP_000922639 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18478.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ArsB family. {ECO 0000305}. # SUBCELLULAR LOCATION ARSB_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 3.A.4.1 the arsenite-antimonite (arsab) efflux family # TIGRFAMs TIGR00935 2a45 # eggNOG COG1055 LUCA # eggNOG ENOG4107R5R Bacteria BLAST swissprot:ARSB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARSB_ECOLI BioCyc ECOL316407:JW3469-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3469-MONOMER BioCyc EcoCyc:ARSF-MONOMER http://biocyc.org/getid?id=EcoCyc:ARSF-MONOMER BioCyc MetaCyc:ARSF-MONOMER http://biocyc.org/getid?id=MetaCyc:ARSF-MONOMER COG COG1055 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1055 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X80057 http://www.ebi.ac.uk/ena/data/view/X80057 EchoBASE EB2148 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2148 EcoGene EG12236 http://www.ecogene.org/geneInfo.php?eg_id=EG12236 EnsemblBacteria AAC76527 http://www.ensemblgenomes.org/id/AAC76527 EnsemblBacteria AAC76527 http://www.ensemblgenomes.org/id/AAC76527 EnsemblBacteria BAE77792 http://www.ensemblgenomes.org/id/BAE77792 EnsemblBacteria BAE77792 http://www.ensemblgenomes.org/id/BAE77792 EnsemblBacteria BAE77792 http://www.ensemblgenomes.org/id/BAE77792 EnsemblBacteria b3502 http://www.ensemblgenomes.org/id/b3502 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0008490 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008490 GO_function GO:0042960 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042960 GO_process GO:0015699 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015699 GO_process GO:0015700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015700 GO_process GO:0046685 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046685 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 948011 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948011 HOGENOM HOG000005271 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000005271&db=HOGENOM6 InParanoid P0AB93 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AB93 IntAct P0AB93 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AB93* InterPro IPR000802 http://www.ebi.ac.uk/interpro/entry/IPR000802 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3469 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3469 KEGG_Gene eco:b3502 http://www.genome.jp/dbget-bin/www_bget?eco:b3502 KEGG_Orthology KO:K03893 http://www.genome.jp/dbget-bin/www_bget?KO:K03893 OMA SEIVEYW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SEIVEYW PRINTS PR00758 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00758 PSORT swissprot:ARSB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARSB_ECOLI PSORT-B swissprot:ARSB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARSB_ECOLI PSORT2 swissprot:ARSB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARSB_ECOLI Pfam PF02040 http://pfam.xfam.org/family/PF02040 Phobius swissprot:ARSB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARSB_ECOLI PhylomeDB P0AB93 http://phylomedb.org/?seqid=P0AB93 ProteinModelPortal P0AB93 http://www.proteinmodelportal.org/query/uniprot/P0AB93 PubMed 1535622 http://www.ncbi.nlm.nih.gov/pubmed/1535622 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7721697 http://www.ncbi.nlm.nih.gov/pubmed/7721697 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417959 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417959 RefSeq WP_000922639 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000922639 STRING 511145.b3502 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3502&targetmode=cogs STRING COG1055 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1055&targetmode=cogs TCDB 3.A.4.1 http://www.tcdb.org/search/result.php?tc=3.A.4.1 TIGRFAMs TIGR00935 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00935 UniProtKB ARSB_ECOLI http://www.uniprot.org/uniprot/ARSB_ECOLI UniProtKB-AC P0AB93 http://www.uniprot.org/uniprot/P0AB93 charge swissprot:ARSB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARSB_ECOLI eggNOG COG1055 http://eggnogapi.embl.de/nog_data/html/tree/COG1055 eggNOG ENOG4107R5R http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107R5R epestfind swissprot:ARSB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARSB_ECOLI garnier swissprot:ARSB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARSB_ECOLI helixturnhelix swissprot:ARSB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARSB_ECOLI hmoment swissprot:ARSB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARSB_ECOLI iep swissprot:ARSB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARSB_ECOLI inforesidue swissprot:ARSB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARSB_ECOLI octanol swissprot:ARSB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARSB_ECOLI pepcoil swissprot:ARSB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARSB_ECOLI pepdigest swissprot:ARSB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARSB_ECOLI pepinfo swissprot:ARSB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARSB_ECOLI pepnet swissprot:ARSB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARSB_ECOLI pepstats swissprot:ARSB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARSB_ECOLI pepwheel swissprot:ARSB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARSB_ECOLI pepwindow swissprot:ARSB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARSB_ECOLI sigcleave swissprot:ARSB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARSB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260235 11 # EcoGene EG13841 ynfC # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GOslim_component GO:0005886 plasma membrane # HAMAP MF_01065 UPF0257 # IntAct P67553 8 # InterPro IPR010646 UPF0257 # Organism YNFC_ECOLI Escherichia coli (strain K12) # PATRIC 32118472 VBIEscCol129921_1656 # PIR C64914 C64914 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF06788 UPF0257 # ProDom PD120112 UPF0257 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNFC_ECOLI UPF0257 lipoprotein YnfC # RefSeq NP_416102 NC_000913.3 # SIMILARITY Belongs to the UPF0257 family. {ECO 0000305}. # SUBCELLULAR LOCATION YNFC_ECOLI Cell membrane {ECO 0000305}; Lipid-anchor {ECO 0000305}. # eggNOG ENOG4105D69 Bacteria # eggNOG ENOG410XPJF LUCA BLAST swissprot:YNFC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNFC_ECOLI BioCyc ECOL316407:JW5258-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5258-MONOMER BioCyc EcoCyc:G6843-MONOMER http://biocyc.org/getid?id=EcoCyc:G6843-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3602 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3602 EcoGene EG13841 http://www.ecogene.org/geneInfo.php?eg_id=EG13841 EnsemblBacteria AAC74657 http://www.ensemblgenomes.org/id/AAC74657 EnsemblBacteria AAC74657 http://www.ensemblgenomes.org/id/AAC74657 EnsemblBacteria BAE76478 http://www.ensemblgenomes.org/id/BAE76478 EnsemblBacteria BAE76478 http://www.ensemblgenomes.org/id/BAE76478 EnsemblBacteria BAE76478 http://www.ensemblgenomes.org/id/BAE76478 EnsemblBacteria b1585 http://www.ensemblgenomes.org/id/b1585 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 946131 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946131 HAMAP MF_01065 http://hamap.expasy.org/unirule/MF_01065 HOGENOM HOG000120796 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120796&db=HOGENOM6 IntAct P67553 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P67553* InterPro IPR010646 http://www.ebi.ac.uk/interpro/entry/IPR010646 KEGG_Gene ecj:JW5258 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5258 KEGG_Gene eco:b1585 http://www.genome.jp/dbget-bin/www_bget?eco:b1585 OMA ANYYLDA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ANYYLDA PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YNFC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNFC_ECOLI PSORT-B swissprot:YNFC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNFC_ECOLI PSORT2 swissprot:YNFC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNFC_ECOLI Pfam PF06788 http://pfam.xfam.org/family/PF06788 Phobius swissprot:YNFC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNFC_ECOLI ProteinModelPortal P67553 http://www.proteinmodelportal.org/query/uniprot/P67553 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416102 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416102 STRING 511145.b1585 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1585&targetmode=cogs UniProtKB YNFC_ECOLI http://www.uniprot.org/uniprot/YNFC_ECOLI UniProtKB-AC P67553 http://www.uniprot.org/uniprot/P67553 charge swissprot:YNFC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNFC_ECOLI eggNOG ENOG4105D69 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D69 eggNOG ENOG410XPJF http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPJF epestfind swissprot:YNFC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNFC_ECOLI garnier swissprot:YNFC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNFC_ECOLI helixturnhelix swissprot:YNFC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNFC_ECOLI hmoment swissprot:YNFC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNFC_ECOLI iep swissprot:YNFC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNFC_ECOLI inforesidue swissprot:YNFC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNFC_ECOLI octanol swissprot:YNFC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNFC_ECOLI pepcoil swissprot:YNFC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNFC_ECOLI pepdigest swissprot:YNFC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNFC_ECOLI pepinfo swissprot:YNFC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNFC_ECOLI pepnet swissprot:YNFC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNFC_ECOLI pepstats swissprot:YNFC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNFC_ECOLI pepwheel swissprot:YNFC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNFC_ECOLI pepwindow swissprot:YNFC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNFC_ECOLI sigcleave swissprot:YNFC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNFC_ECOLI ## Database ID URL or Descriptions # AltName CITX_ECOLI Apo-ACP nucleodityltransferase # AltName CITX_ECOLI Holo-ACP synthase # AltName CITX_ECOLI Holo-citrate lyase synthase # BioGrid 4260860 9 # CATALYTIC ACTIVITY CITX_ECOLI 2'-(5-triphosphoribosyl)-3'-dephospho-CoA + citrate lyase apo-[acyl-carrier protein] = citrate lyase holo- [acyl-carrier protein] + diphosphate. {ECO 0000269|PubMed 10924139, ECO 0000269|PubMed 11042274}. # EcoGene EG13540 citX # FUNCTION CITX_ECOLI Transfers 2-(5''-triphosphoribosyl)-3'- dephosphocoenzyme-A on a serine residue to the apo-acyl carrier protein (gamma chain) of the citrate lyase to yield holo-acyl carrier protein. {ECO 0000269|PubMed 10924139, ECO 0000269|PubMed 11042274}. # GO_function GO:0050519 holo-citrate lyase synthase activity; IDA:EcoCyc. # GO_process GO:0018247 protein-phosphoribosyl dephospho-coenzyme A linkage; IDA:EcoCyc. # GO_process GO:0051191 prosthetic group biosynthetic process; IEA:InterPro. # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0051186 cofactor metabolic process # HAMAP MF_00398 CitX # INDUCTION Repressed by H-NS. Part of the citCDEFXG operon. {ECO:0000269|PubMed 19429622}. # IntAct P0A6G5 8 # InterPro IPR005551 CitX # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko02020 Two-component system # Organism CITX_ECOLI Escherichia coli (strain K12) # PATRIC 32116408 VBIEscCol129921_0644 # PIR D64795 D64795 # Pfam PF03802 CitX # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CITX_ECOLI Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase # RefSeq NP_415147 NC_000913.3 # RefSeq WP_000550422 NZ_LN832404.1 # SIMILARITY Belongs to the CitX family. {ECO 0000305}. # TIGRFAMs TIGR03124 citrate_citX # eggNOG COG3697 LUCA # eggNOG ENOG4105YGP Bacteria BLAST swissprot:CITX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CITX_ECOLI BioCyc ECOL316407:JW0606-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0606-MONOMER BioCyc EcoCyc:G6340-MONOMER http://biocyc.org/getid?id=EcoCyc:G6340-MONOMER BioCyc MetaCyc:G6340-MONOMER http://biocyc.org/getid?id=MetaCyc:G6340-MONOMER COG COG3697 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3697 DOI 10.1016/S0014-5793(00)02105-0 http://dx.doi.org/10.1016/S0014-5793(00)02105-0 DOI 10.1021/bi000401r http://dx.doi.org/10.1021/bi000401r DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00108-09 http://dx.doi.org/10.1128/JB.00108-09 EC_number EC:2.7.7.61 {ECO:0000269|PubMed:10924139, ECO:0000269|PubMed:11042274} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.61 {ECO:0000269|PubMed:10924139, ECO:0000269|PubMed:11042274} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 ENZYME 2.7.7.61 {ECO:0000269|PubMed:10924139, ECO:0000269|PubMed:11042274} http://enzyme.expasy.org/EC/2.7.7.61 {ECO:0000269|PubMed:10924139, ECO:0000269|PubMed:11042274} EchoBASE EB3310 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3310 EcoGene EG13540 http://www.ecogene.org/geneInfo.php?eg_id=EG13540 EnsemblBacteria AAC73715 http://www.ensemblgenomes.org/id/AAC73715 EnsemblBacteria AAC73715 http://www.ensemblgenomes.org/id/AAC73715 EnsemblBacteria BAE76354 http://www.ensemblgenomes.org/id/BAE76354 EnsemblBacteria BAE76354 http://www.ensemblgenomes.org/id/BAE76354 EnsemblBacteria BAE76354 http://www.ensemblgenomes.org/id/BAE76354 EnsemblBacteria b0614 http://www.ensemblgenomes.org/id/b0614 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0050519 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050519 GO_process GO:0018247 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018247 GO_process GO:0051191 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051191 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GeneID 949084 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949084 HAMAP MF_00398 http://hamap.expasy.org/unirule/MF_00398 HOGENOM HOG000130710 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000130710&db=HOGENOM6 InParanoid P0A6G5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6G5 IntAct P0A6G5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6G5* IntEnz 2.7.7.61 {ECO:0000269|PubMed:10924139, ECO:0000269|PubMed:11042274} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.61 {ECO:0000269|PubMed:10924139, ECO:0000269|PubMed:11042274} InterPro IPR005551 http://www.ebi.ac.uk/interpro/entry/IPR005551 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0606 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0606 KEGG_Gene eco:b0614 http://www.genome.jp/dbget-bin/www_bget?eco:b0614 KEGG_Orthology KO:K05964 http://www.genome.jp/dbget-bin/www_bget?KO:K05964 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA AFDIVIK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AFDIVIK PSORT swissprot:CITX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CITX_ECOLI PSORT-B swissprot:CITX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CITX_ECOLI PSORT2 swissprot:CITX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CITX_ECOLI Pfam PF03802 http://pfam.xfam.org/family/PF03802 Phobius swissprot:CITX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CITX_ECOLI PhylomeDB P0A6G5 http://phylomedb.org/?seqid=P0A6G5 ProteinModelPortal P0A6G5 http://www.proteinmodelportal.org/query/uniprot/P0A6G5 PubMed 10924139 http://www.ncbi.nlm.nih.gov/pubmed/10924139 PubMed 11042274 http://www.ncbi.nlm.nih.gov/pubmed/11042274 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19429622 http://www.ncbi.nlm.nih.gov/pubmed/19429622 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9696764 http://www.ncbi.nlm.nih.gov/pubmed/9696764 RefSeq NP_415147 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415147 RefSeq WP_000550422 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000550422 STRING 511145.b0614 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0614&targetmode=cogs STRING COG3697 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3697&targetmode=cogs TIGRFAMs TIGR03124 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03124 UniProtKB CITX_ECOLI http://www.uniprot.org/uniprot/CITX_ECOLI UniProtKB-AC P0A6G5 http://www.uniprot.org/uniprot/P0A6G5 charge swissprot:CITX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CITX_ECOLI eggNOG COG3697 http://eggnogapi.embl.de/nog_data/html/tree/COG3697 eggNOG ENOG4105YGP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105YGP epestfind swissprot:CITX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CITX_ECOLI garnier swissprot:CITX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CITX_ECOLI helixturnhelix swissprot:CITX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CITX_ECOLI hmoment swissprot:CITX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CITX_ECOLI iep swissprot:CITX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CITX_ECOLI inforesidue swissprot:CITX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CITX_ECOLI octanol swissprot:CITX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CITX_ECOLI pepcoil swissprot:CITX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CITX_ECOLI pepdigest swissprot:CITX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CITX_ECOLI pepinfo swissprot:CITX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CITX_ECOLI pepnet swissprot:CITX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CITX_ECOLI pepstats swissprot:CITX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CITX_ECOLI pepwheel swissprot:CITX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CITX_ECOLI pepwindow swissprot:CITX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CITX_ECOLI sigcleave swissprot:CITX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CITX_ECOLI ## Database ID URL or Descriptions # BioGrid 4259694 5 # EcoGene EG14052 yegI # GO_function GO:0004672 protein kinase activity; IEA:InterPro. # GO_function GO:0005524 ATP binding; IEA:InterPro. # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # InterPro IPR000719 Prot_kinase_dom # InterPro IPR011009 Kinase-like_dom # InterPro IPR016960 UCP030823_PK_HhH # Organism YEGI_ECOLI Escherichia coli (strain K12) # PATRIC 32119473 VBIEscCol129921_2147 # PIR E64973 E64973 # PIRSF PIRSF030823 UCP030823_PK_HhH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEGI_ECOLI Uncharacterized protein YegI # RefSeq NP_416574 NC_000913.3 # RefSeq WP_000856081 NZ_LN832404.1 # SUPFAM SSF56112 SSF56112 # eggNOG COG4248 LUCA # eggNOG ENOG4106E1W Bacteria BLAST swissprot:YEGI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEGI_ECOLI BioCyc ECOL316407:JW2055-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2055-MONOMER BioCyc EcoCyc:G7109-MONOMER http://biocyc.org/getid?id=EcoCyc:G7109-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3805 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3805 EcoGene EG14052 http://www.ecogene.org/geneInfo.php?eg_id=EG14052 EnsemblBacteria AAC75131 http://www.ensemblgenomes.org/id/AAC75131 EnsemblBacteria AAC75131 http://www.ensemblgenomes.org/id/AAC75131 EnsemblBacteria BAE76577 http://www.ensemblgenomes.org/id/BAE76577 EnsemblBacteria BAE76577 http://www.ensemblgenomes.org/id/BAE76577 EnsemblBacteria BAE76577 http://www.ensemblgenomes.org/id/BAE76577 EnsemblBacteria b2070 http://www.ensemblgenomes.org/id/b2070 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004672 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004672 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GeneID 947159 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947159 HOGENOM HOG000122010 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122010&db=HOGENOM6 InParanoid P76393 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76393 InterPro IPR000719 http://www.ebi.ac.uk/interpro/entry/IPR000719 InterPro IPR011009 http://www.ebi.ac.uk/interpro/entry/IPR011009 InterPro IPR016960 http://www.ebi.ac.uk/interpro/entry/IPR016960 KEGG_Gene ecj:JW2055 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2055 KEGG_Gene eco:b2070 http://www.genome.jp/dbget-bin/www_bget?eco:b2070 OMA GHLADCP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GHLADCP PSORT swissprot:YEGI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEGI_ECOLI PSORT-B swissprot:YEGI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEGI_ECOLI PSORT2 swissprot:YEGI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEGI_ECOLI Phobius swissprot:YEGI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEGI_ECOLI ProteinModelPortal P76393 http://www.proteinmodelportal.org/query/uniprot/P76393 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416574 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416574 RefSeq WP_000856081 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000856081 STRING 511145.b2070 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2070&targetmode=cogs SUPFAM SSF56112 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56112 UniProtKB YEGI_ECOLI http://www.uniprot.org/uniprot/YEGI_ECOLI UniProtKB-AC P76393 http://www.uniprot.org/uniprot/P76393 charge swissprot:YEGI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEGI_ECOLI eggNOG COG4248 http://eggnogapi.embl.de/nog_data/html/tree/COG4248 eggNOG ENOG4106E1W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106E1W epestfind swissprot:YEGI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEGI_ECOLI garnier swissprot:YEGI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEGI_ECOLI helixturnhelix swissprot:YEGI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEGI_ECOLI hmoment swissprot:YEGI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEGI_ECOLI iep swissprot:YEGI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEGI_ECOLI inforesidue swissprot:YEGI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEGI_ECOLI octanol swissprot:YEGI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEGI_ECOLI pepcoil swissprot:YEGI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEGI_ECOLI pepdigest swissprot:YEGI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEGI_ECOLI pepinfo swissprot:YEGI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEGI_ECOLI pepnet swissprot:YEGI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEGI_ECOLI pepstats swissprot:YEGI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEGI_ECOLI pepwheel swissprot:YEGI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEGI_ECOLI pepwindow swissprot:YEGI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEGI_ECOLI sigcleave swissprot:YEGI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEGI_ECOLI ## Database ID URL or Descriptions # BioGrid 4260802 12 # EcoGene EG13682 ybjM # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # IntAct P64439 4 # InterPro IPR020368 Uncharacterised_YbjM # Organism YBJM_ECOLI Escherichia coli (strain K12) # PATRIC 32116901 VBIEscCol129921_0876 # PIR H64822 H64822 # Pfam PF11045 YbjM # ProDom PD079046 Inner_membrane_protein_YbjM # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBJM_ECOLI Inner membrane protein YbjM # RefSeq NP_415369 NC_000913.3 # RefSeq WP_000681108 NZ_LN832404.1 # SUBCELLULAR LOCATION YBJM_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG ENOG4105GWF Bacteria # eggNOG ENOG4111P9N LUCA BLAST swissprot:YBJM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBJM_ECOLI BioCyc ECOL316407:JW0832-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0832-MONOMER BioCyc EcoCyc:G6446-MONOMER http://biocyc.org/getid?id=EcoCyc:G6446-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3446 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3446 EcoGene EG13682 http://www.ecogene.org/geneInfo.php?eg_id=EG13682 EnsemblBacteria AAC73935 http://www.ensemblgenomes.org/id/AAC73935 EnsemblBacteria AAC73935 http://www.ensemblgenomes.org/id/AAC73935 EnsemblBacteria BAE76367 http://www.ensemblgenomes.org/id/BAE76367 EnsemblBacteria BAE76367 http://www.ensemblgenomes.org/id/BAE76367 EnsemblBacteria BAE76367 http://www.ensemblgenomes.org/id/BAE76367 EnsemblBacteria b0848 http://www.ensemblgenomes.org/id/b0848 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 945477 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945477 HOGENOM HOG000118227 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118227&db=HOGENOM6 IntAct P64439 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P64439* InterPro IPR020368 http://www.ebi.ac.uk/interpro/entry/IPR020368 KEGG_Gene ecj:JW0832 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0832 KEGG_Gene eco:b0848 http://www.genome.jp/dbget-bin/www_bget?eco:b0848 OMA NTPMRSF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NTPMRSF PSORT swissprot:YBJM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBJM_ECOLI PSORT-B swissprot:YBJM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBJM_ECOLI PSORT2 swissprot:YBJM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBJM_ECOLI Pfam PF11045 http://pfam.xfam.org/family/PF11045 Phobius swissprot:YBJM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBJM_ECOLI ProteinModelPortal P64439 http://www.proteinmodelportal.org/query/uniprot/P64439 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415369 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415369 RefSeq WP_000681108 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000681108 STRING 511145.b0848 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0848&targetmode=cogs UniProtKB YBJM_ECOLI http://www.uniprot.org/uniprot/YBJM_ECOLI UniProtKB-AC P64439 http://www.uniprot.org/uniprot/P64439 charge swissprot:YBJM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBJM_ECOLI eggNOG ENOG4105GWF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105GWF eggNOG ENOG4111P9N http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111P9N epestfind swissprot:YBJM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBJM_ECOLI garnier swissprot:YBJM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBJM_ECOLI helixturnhelix swissprot:YBJM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBJM_ECOLI hmoment swissprot:YBJM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBJM_ECOLI iep swissprot:YBJM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBJM_ECOLI inforesidue swissprot:YBJM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBJM_ECOLI octanol swissprot:YBJM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBJM_ECOLI pepcoil swissprot:YBJM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBJM_ECOLI pepdigest swissprot:YBJM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBJM_ECOLI pepinfo swissprot:YBJM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBJM_ECOLI pepnet swissprot:YBJM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBJM_ECOLI pepstats swissprot:YBJM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBJM_ECOLI pepwheel swissprot:YBJM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBJM_ECOLI pepwindow swissprot:YBJM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBJM_ECOLI sigcleave swissprot:YBJM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBJM_ECOLI ## Database ID URL or Descriptions # AltName PANF_ECOLI Pantothenate permease # BioGrid 4262451 166 # CDD cd10327 SLC5sbd_PanF # EcoGene EG10685 panF # FUNCTION PANF_ECOLI Catalyzes the sodium-dependent uptake of extracellular pantothenate. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0015081 sodium ion transmembrane transporter activity; IEA:InterPro. # GO_function GO:0015233 pantothenate transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0015293 symporter activity; IDA:EcoCyc. # GO_function GO:0031402 sodium ion binding; IEA:InterPro. # GO_process GO:0015887 pantothenate transmembrane transport; IDA:EcoCyc. # GO_process GO:0071436 sodium ion export; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0055085 transmembrane transport # InterPro IPR001734 Na/solute_symporter # InterPro IPR011849 Na/pantothenate_symporter # InterPro IPR018212 Na/solute_symporter_CS # Organism PANF_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11819 PTHR11819 # PATRIC 32121946 VBIEscCol129921_3357 # PROSITE PS00456 NA_SOLUT_SYMP_1 # PROSITE PS00457 NA_SOLUT_SYMP_2 # PROSITE PS50283 NA_SOLUT_SYMP_3 # Pfam PF00474 SSF # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PANF_ECOLI Sodium/pantothenate symporter # RefSeq NP_417724 NC_000913.3 # RefSeq WP_001175728 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA23747.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAA58061.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. {ECO 0000305}. # SUBCELLULAR LOCATION PANF_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.21.1:the solute sodium symporter (sss) family # TIGRFAMs TIGR00813 sss # TIGRFAMs TIGR02119 panF # eggNOG COG4145 LUCA # eggNOG ENOG4108IA2 Bacteria BLAST swissprot:PANF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PANF_ECOLI BioCyc ECOL316407:JW3226-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3226-MONOMER BioCyc EcoCyc:PANF-MONOMER http://biocyc.org/getid?id=EcoCyc:PANF-MONOMER BioCyc MetaCyc:PANF-MONOMER http://biocyc.org/getid?id=MetaCyc:PANF-MONOMER COG COG4145 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4145 DIP DIP-10439N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10439N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M30953 http://www.ebi.ac.uk/ena/data/view/M30953 EMBL M83198 http://www.ebi.ac.uk/ena/data/view/M83198 EMBL S67010 http://www.ebi.ac.uk/ena/data/view/S67010 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB0679 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0679 EcoGene EG10685 http://www.ecogene.org/geneInfo.php?eg_id=EG10685 EnsemblBacteria AAC76290 http://www.ensemblgenomes.org/id/AAC76290 EnsemblBacteria AAC76290 http://www.ensemblgenomes.org/id/AAC76290 EnsemblBacteria BAE77299 http://www.ensemblgenomes.org/id/BAE77299 EnsemblBacteria BAE77299 http://www.ensemblgenomes.org/id/BAE77299 EnsemblBacteria BAE77299 http://www.ensemblgenomes.org/id/BAE77299 EnsemblBacteria b3258 http://www.ensemblgenomes.org/id/b3258 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015081 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015081 GO_function GO:0015233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015233 GO_function GO:0015293 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293 GO_function GO:0031402 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031402 GO_process GO:0015887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015887 GO_process GO:0071436 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071436 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 947752 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947752 HOGENOM HOG000281958 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000281958&db=HOGENOM6 InParanoid P16256 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P16256 InterPro IPR001734 http://www.ebi.ac.uk/interpro/entry/IPR001734 InterPro IPR011849 http://www.ebi.ac.uk/interpro/entry/IPR011849 InterPro IPR018212 http://www.ebi.ac.uk/interpro/entry/IPR018212 KEGG_Gene ecj:JW3226 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3226 KEGG_Gene eco:b3258 http://www.genome.jp/dbget-bin/www_bget?eco:b3258 KEGG_Orthology KO:K14392 http://www.genome.jp/dbget-bin/www_bget?KO:K14392 OMA MMATYGS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MMATYGS PANTHER PTHR11819 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11819 PROSITE PS00456 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00456 PROSITE PS00457 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00457 PROSITE PS50283 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50283 PSORT swissprot:PANF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PANF_ECOLI PSORT-B swissprot:PANF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PANF_ECOLI PSORT2 swissprot:PANF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PANF_ECOLI Pfam PF00474 http://pfam.xfam.org/family/PF00474 Phobius swissprot:PANF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PANF_ECOLI PhylomeDB P16256 http://phylomedb.org/?seqid=P16256 ProteinModelPortal P16256 http://www.proteinmodelportal.org/query/uniprot/P16256 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2193919 http://www.ncbi.nlm.nih.gov/pubmed/2193919 PubMed 8226664 http://www.ncbi.nlm.nih.gov/pubmed/8226664 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417724 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417724 RefSeq WP_001175728 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001175728 STRING 511145.b3258 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3258&targetmode=cogs STRING COG4145 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4145&targetmode=cogs TCDB 2.A.21.1 http://www.tcdb.org/search/result.php?tc=2.A.21.1 TIGRFAMs TIGR00813 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00813 TIGRFAMs TIGR02119 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02119 UniProtKB PANF_ECOLI http://www.uniprot.org/uniprot/PANF_ECOLI UniProtKB-AC P16256 http://www.uniprot.org/uniprot/P16256 charge swissprot:PANF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PANF_ECOLI eggNOG COG4145 http://eggnogapi.embl.de/nog_data/html/tree/COG4145 eggNOG ENOG4108IA2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108IA2 epestfind swissprot:PANF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PANF_ECOLI garnier swissprot:PANF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PANF_ECOLI helixturnhelix swissprot:PANF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PANF_ECOLI hmoment swissprot:PANF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PANF_ECOLI iep swissprot:PANF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PANF_ECOLI inforesidue swissprot:PANF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PANF_ECOLI octanol swissprot:PANF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PANF_ECOLI pepcoil swissprot:PANF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PANF_ECOLI pepdigest swissprot:PANF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PANF_ECOLI pepinfo swissprot:PANF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PANF_ECOLI pepnet swissprot:PANF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PANF_ECOLI pepstats swissprot:PANF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PANF_ECOLI pepwheel swissprot:PANF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PANF_ECOLI pepwindow swissprot:PANF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PANF_ECOLI sigcleave swissprot:PANF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PANF_ECOLI ## Database ID URL or Descriptions # BioGrid 4262241 7 # DOMAIN FLHD_ECOLI The C-terminal region contains a putative helix-turn-helix (HTH) motif, suggesting that this region may bind DNA. {ECO 0000269|PubMed 11169099}. # EcoGene EG10320 flhD # FUNCTION FLHD_ECOLI Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways. {ECO 0000269|PubMed 11169100, ECO 0000269|PubMed 15941987, ECO 0000269|PubMed 18765794, ECO 0000269|PubMed 7961507}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006351 transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0044780 bacterial-type flagellum assembly; IEA:InterPro. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IMP:EcoCyc. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:1902208 regulation of bacterial-type flagellum assembly; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # HAMAP MF_00725 FlhD # INDUCTION FLHD_ECOLI Expression is regulated by a large number of systems, including induction by quorum sensing via the two-component regulatory system QseB/QseC, induction by cAMP-CRP, repression by high osmolarity via OmpR and repression by H-NS. {ECO 0000269|PubMed 10601207, ECO 0000269|PubMed 11929534, ECO 0000269|PubMed 7642497}. # IntAct P0A8S9 14 # InterPro IPR023559 Flagellar_FlhD # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Pathway ko02020 Two-component system # KEGG_Pathway ko02040 Flagellar assembly # MASS SPECTROMETRY Mass=13317; Method=Unknown; Range=1-116; Evidence={ECO:0000269|PubMed 10601207}; # MISCELLANEOUS Has been reported to be involved in cell division regulation, but it was later shown that this is not the case. {ECO:0000305|PubMed 20546312}. # Organism FLHD_ECOLI Escherichia coli (strain K12) # PATRIC 32119111 VBIEscCol129921_1973 # PDB 1G8E X-ray; 1.80 A; A/B=1-116 # PDB 2AVU X-ray; 3.00 A; A/B/C/D=1-116 # PDB 4ES4 X-ray; 2.90 A; B/D/F/H=1-116 # PIR A27735 XMECFB # Pfam PF05247 FlhD # ProDom PD015582 Flagellar_transcriptional_act # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FLHD_ECOLI Flagellar transcriptional regulator FlhD # RefSeq NP_416406 NC_000913.3 # RefSeq WP_001295647 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA23787.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA15713.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the FlhD family. {ECO 0000305}. # SUBCELLULAR LOCATION FLHD_ECOLI Cytoplasm. # SUBUNIT Homodimer; disulfide-linked. Forms a heterohexamer composed of two FlhC and four FlhD subunits. Each FlhC binds a FlhD dimer, forming a heterotrimer, and a hexamer assembles by dimerization of two heterotrimers. {ECO:0000269|PubMed 16337229}. # SUPFAM SSF63592 SSF63592 # eggNOG ENOG4105GEH Bacteria # eggNOG ENOG4111JRF LUCA BLAST swissprot:FLHD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLHD_ECOLI BioCyc ECOL316407:JW1881-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1881-MONOMER BioCyc EcoCyc:EG10320-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10320-MONOMER DIP DIP-9646N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9646N DOI 10.1016/j.jmb.2005.11.020 http://dx.doi.org/10.1016/j.jmb.2005.11.020 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2001.02247.x http://dx.doi.org/10.1046/j.1365-2958.2001.02247.x DOI 10.1046/j.1365-2958.2001.02248.x http://dx.doi.org/10.1046/j.1365-2958.2001.02248.x DOI 10.1046/j.1365-2958.2002.02803.x http://dx.doi.org/10.1046/j.1365-2958.2002.02803.x DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1099/mic.0.27879-0 http://dx.doi.org/10.1099/mic.0.27879-0 DOI 10.1101/gad.475808 http://dx.doi.org/10.1101/gad.475808 DOI 10.1111/j.1574-6968.2010.02021.x http://dx.doi.org/10.1111/j.1574-6968.2010.02021.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M19439 http://www.ebi.ac.uk/ena/data/view/M19439 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0316 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0316 EcoGene EG10320 http://www.ecogene.org/geneInfo.php?eg_id=EG10320 EnsemblBacteria AAC74962 http://www.ensemblgenomes.org/id/AAC74962 EnsemblBacteria AAC74962 http://www.ensemblgenomes.org/id/AAC74962 EnsemblBacteria BAA15713 http://www.ensemblgenomes.org/id/BAA15713 EnsemblBacteria BAA15713 http://www.ensemblgenomes.org/id/BAA15713 EnsemblBacteria BAA15713 http://www.ensemblgenomes.org/id/BAA15713 EnsemblBacteria b1892 http://www.ensemblgenomes.org/id/b1892 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0044780 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044780 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GO_process GO:1902208 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902208 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 945442 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945442 HAMAP MF_00725 http://hamap.expasy.org/unirule/MF_00725 HOGENOM HOG000254676 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000254676&db=HOGENOM6 IntAct P0A8S9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8S9* InterPro IPR023559 http://www.ebi.ac.uk/interpro/entry/IPR023559 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW1881 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1881 KEGG_Gene eco:b1892 http://www.genome.jp/dbget-bin/www_bget?eco:b1892 KEGG_Orthology KO:K02403 http://www.genome.jp/dbget-bin/www_bget?KO:K02403 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 KEGG_Pathway ko02040 http://www.genome.jp/kegg-bin/show_pathway?ko02040 OMA REDKPMG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=REDKPMG PDB 1G8E http://www.ebi.ac.uk/pdbe-srv/view/entry/1G8E PDB 2AVU http://www.ebi.ac.uk/pdbe-srv/view/entry/2AVU PDB 4ES4 http://www.ebi.ac.uk/pdbe-srv/view/entry/4ES4 PDBsum 1G8E http://www.ebi.ac.uk/pdbsum/1G8E PDBsum 2AVU http://www.ebi.ac.uk/pdbsum/2AVU PDBsum 4ES4 http://www.ebi.ac.uk/pdbsum/4ES4 PSORT swissprot:FLHD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLHD_ECOLI PSORT-B swissprot:FLHD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLHD_ECOLI PSORT2 swissprot:FLHD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLHD_ECOLI Pfam PF05247 http://pfam.xfam.org/family/PF05247 Phobius swissprot:FLHD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLHD_ECOLI ProteinModelPortal P0A8S9 http://www.proteinmodelportal.org/query/uniprot/P0A8S9 PubMed 10601207 http://www.ncbi.nlm.nih.gov/pubmed/10601207 PubMed 11169099 http://www.ncbi.nlm.nih.gov/pubmed/11169099 PubMed 11169100 http://www.ncbi.nlm.nih.gov/pubmed/11169100 PubMed 11929534 http://www.ncbi.nlm.nih.gov/pubmed/11929534 PubMed 15941987 http://www.ncbi.nlm.nih.gov/pubmed/15941987 PubMed 16337229 http://www.ncbi.nlm.nih.gov/pubmed/16337229 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18765794 http://www.ncbi.nlm.nih.gov/pubmed/18765794 PubMed 20546312 http://www.ncbi.nlm.nih.gov/pubmed/20546312 PubMed 2832369 http://www.ncbi.nlm.nih.gov/pubmed/2832369 PubMed 7642497 http://www.ncbi.nlm.nih.gov/pubmed/7642497 PubMed 7961507 http://www.ncbi.nlm.nih.gov/pubmed/7961507 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416406 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416406 RefSeq WP_001295647 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295647 SMR P0A8S9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8S9 STRING 511145.b1892 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1892&targetmode=cogs SUPFAM SSF63592 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63592 UniProtKB FLHD_ECOLI http://www.uniprot.org/uniprot/FLHD_ECOLI UniProtKB-AC P0A8S9 http://www.uniprot.org/uniprot/P0A8S9 charge swissprot:FLHD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLHD_ECOLI eggNOG ENOG4105GEH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105GEH eggNOG ENOG4111JRF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111JRF epestfind swissprot:FLHD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLHD_ECOLI garnier swissprot:FLHD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLHD_ECOLI helixturnhelix swissprot:FLHD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLHD_ECOLI hmoment swissprot:FLHD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLHD_ECOLI iep swissprot:FLHD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLHD_ECOLI inforesidue swissprot:FLHD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLHD_ECOLI octanol swissprot:FLHD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLHD_ECOLI pepcoil swissprot:FLHD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLHD_ECOLI pepdigest swissprot:FLHD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLHD_ECOLI pepinfo swissprot:FLHD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLHD_ECOLI pepnet swissprot:FLHD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLHD_ECOLI pepstats swissprot:FLHD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLHD_ECOLI pepwheel swissprot:FLHD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLHD_ECOLI pepwindow swissprot:FLHD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLHD_ECOLI sigcleave swissprot:FLHD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLHD_ECOLI ## Database ID URL or Descriptions # BioGrid 4259389 48 # CDD cd01434 EFG_mtEFG1_IV # EcoGene EG10360 fusA # FUNCTION EFG_ECOLI Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. # GO_component GO:0005737 cytoplasm; IDA:UniProtKB. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003746 translation elongation factor activity; IBA:GO_Central. # GO_function GO:0003924 GTPase activity; IBA:GO_Central. # GO_function GO:0005525 GTP binding; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003924 GTPase activity # GOslim_function GO:0008135 translation factor activity, RNA binding # GOslim_function GO:0043167 ion binding # Gene3D 3.30.230.10 -; 1. # Gene3D 3.30.70.240 -; 1. # Gene3D 3.40.50.300 -; 1. # HAMAP MF_00054_B EF_G_EF_2_B # IntAct P0A6M8 42 # InterPro IPR000640 EFG_V # InterPro IPR000795 TF_GTP-bd_dom # InterPro IPR004161 EFTu-like_2 # InterPro IPR004540 Transl_elong_EFG/EF2 # InterPro IPR005225 Small_GTP-bd_dom # InterPro IPR005517 Transl_elong_EFG/EF2_IV # InterPro IPR009000 Transl_B-barrel # InterPro IPR009022 EFG_III-V # InterPro IPR014721 Ribosomal_S5_D2-typ_fold_subgr # InterPro IPR020568 Ribosomal_S5_D2-typ_fold # InterPro IPR027417 P-loop_NTPase # InterPro IPR031157 G_TR_CS # KEGG_Brite ko03012 Translation factors # Organism EFG_ECOLI Escherichia coli (strain K12) # PATRIC 32122112 VBIEscCol129921_3433 # PDB 2RDO EM; 9.10 A; 7=1-704 # PDB 3J0E EM; 9.90 A; H=2-703 # PDB 3J9Z EM; 3.60 A; S1=2-703 # PDB 3JA1 EM; 3.60 A; S3=2-703 # PDB 4V7B EM; 6.80 A; AY=1-704 # PDB 4V7D EM; 7.60 A; BZ=2-704 # PDB 4V9O X-ray; 2.90 A; BV/DV/FV/HV=1-704 # PDB 4V9P X-ray; 2.90 A; BV/DV/FV/HV=1-704 # PIR G65127 EFECG # PRINTS PR00315 ELONGATNFCT # PROSITE PS00301 G_TR_1 # PROSITE PS51722 G_TR_2 # Pfam PF00679 EFG_C # Pfam PF03144 GTP_EFTU_D2 # Pfam PF03764 EFG_IV # Pfam PF14492 EFG_II # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EFG_ECOLI Elongation factor G # RefSeq NP_417799 NC_000913.3 # RefSeq WP_000124700 NZ_LN832404.1 # SIMILARITY Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. {ECO 0000305}. # SIMILARITY Contains 1 tr-type G (guanine nucleotide-binding) domain. {ECO 0000305}. # SMART SM00838 EFG_C # SMART SM00889 EFG_IV # SUBCELLULAR LOCATION EFG_ECOLI Cytoplasm. # SUPFAM SSF50447 SSF50447 # SUPFAM SSF52540 SSF52540 # SUPFAM SSF54211 SSF54211 # SUPFAM SSF54980 SSF54980; 2 # TIGRFAMs TIGR00231 small_GTP # TIGRFAMs TIGR00484 EF-G # eggNOG COG0480 LUCA # eggNOG ENOG4105CEJ Bacteria BLAST swissprot:EFG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EFG_ECOLI BioCyc ECOL316407:JW3302-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3302-MONOMER BioCyc EcoCyc:EG10360-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10360-MONOMER COG COG0480 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0480 DIP DIP-31836N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31836N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1016/0014-5793(81)80237-2 http://dx.doi.org/10.1016/0014-5793(81)80237-2 DOI 10.1016/0014-5793(82)80503-6 http://dx.doi.org/10.1016/0014-5793(82)80503-6 DOI 10.1016/0378-1119(80)90012-8 http://dx.doi.org/10.1016/0378-1119(80)90012-8 DOI 10.1016/0378-1119(92)90014-G http://dx.doi.org/10.1016/0378-1119(92)90014-G DOI 10.1016/S0092-8674(03)00476-8 http://dx.doi.org/10.1016/S0092-8674(03)00476-8 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/nar/12.4.2181 http://dx.doi.org/10.1093/nar/12.4.2181 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01689 http://www.ebi.ac.uk/ena/data/view/J01689 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X00415 http://www.ebi.ac.uk/ena/data/view/X00415 EMBL X64592 http://www.ebi.ac.uk/ena/data/view/X64592 EMBL X65735 http://www.ebi.ac.uk/ena/data/view/X65735 EchoBASE EB0355 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0355 EcoGene EG10360 http://www.ecogene.org/geneInfo.php?eg_id=EG10360 EnsemblBacteria AAC76365 http://www.ensemblgenomes.org/id/AAC76365 EnsemblBacteria AAC76365 http://www.ensemblgenomes.org/id/AAC76365 EnsemblBacteria BAE77951 http://www.ensemblgenomes.org/id/BAE77951 EnsemblBacteria BAE77951 http://www.ensemblgenomes.org/id/BAE77951 EnsemblBacteria BAE77951 http://www.ensemblgenomes.org/id/BAE77951 EnsemblBacteria b3340 http://www.ensemblgenomes.org/id/b3340 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003746 GO_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GOslim_function GO:0008135 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008135 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.30.230.10 http://www.cathdb.info/version/latest/superfamily/3.30.230.10 Gene3D 3.30.70.240 http://www.cathdb.info/version/latest/superfamily/3.30.70.240 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947847 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947847 HAMAP MF_00054_B http://hamap.expasy.org/unirule/MF_00054_B HOGENOM HOG000231585 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231585&db=HOGENOM6 InParanoid P0A6M8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6M8 IntAct P0A6M8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6M8* InterPro IPR000640 http://www.ebi.ac.uk/interpro/entry/IPR000640 InterPro IPR000795 http://www.ebi.ac.uk/interpro/entry/IPR000795 InterPro IPR004161 http://www.ebi.ac.uk/interpro/entry/IPR004161 InterPro IPR004540 http://www.ebi.ac.uk/interpro/entry/IPR004540 InterPro IPR005225 http://www.ebi.ac.uk/interpro/entry/IPR005225 InterPro IPR005517 http://www.ebi.ac.uk/interpro/entry/IPR005517 InterPro IPR009000 http://www.ebi.ac.uk/interpro/entry/IPR009000 InterPro IPR009022 http://www.ebi.ac.uk/interpro/entry/IPR009022 InterPro IPR014721 http://www.ebi.ac.uk/interpro/entry/IPR014721 InterPro IPR020568 http://www.ebi.ac.uk/interpro/entry/IPR020568 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR031157 http://www.ebi.ac.uk/interpro/entry/IPR031157 KEGG_Brite ko03012 http://www.genome.jp/dbget-bin/www_bget?ko03012 KEGG_Gene ecj:JW3302 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3302 KEGG_Gene eco:b3340 http://www.genome.jp/dbget-bin/www_bget?eco:b3340 KEGG_Orthology KO:K02355 http://www.genome.jp/dbget-bin/www_bget?KO:K02355 OMA KLGVAIQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KLGVAIQ PDB 2RDO http://www.ebi.ac.uk/pdbe-srv/view/entry/2RDO PDB 3J0E http://www.ebi.ac.uk/pdbe-srv/view/entry/3J0E PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDBsum 2RDO http://www.ebi.ac.uk/pdbsum/2RDO PDBsum 3J0E http://www.ebi.ac.uk/pdbsum/3J0E PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PRINTS PR00315 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00315 PROSITE PS00301 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00301 PROSITE PS51722 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51722 PSORT swissprot:EFG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EFG_ECOLI PSORT-B swissprot:EFG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EFG_ECOLI PSORT2 swissprot:EFG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EFG_ECOLI Pfam PF00679 http://pfam.xfam.org/family/PF00679 Pfam PF03144 http://pfam.xfam.org/family/PF03144 Pfam PF03764 http://pfam.xfam.org/family/PF03764 Pfam PF14492 http://pfam.xfam.org/family/PF14492 Phobius swissprot:EFG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EFG_ECOLI PhylomeDB P0A6M8 http://phylomedb.org/?seqid=P0A6M8 ProteinModelPortal P0A6M8 http://www.proteinmodelportal.org/query/uniprot/P0A6M8 PubMed 12859903 http://www.ncbi.nlm.nih.gov/pubmed/12859903 PubMed 1398129 http://www.ncbi.nlm.nih.gov/pubmed/1398129 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 6322136 http://www.ncbi.nlm.nih.gov/pubmed/6322136 PubMed 6989816 http://www.ncbi.nlm.nih.gov/pubmed/6989816 PubMed 7011903 http://www.ncbi.nlm.nih.gov/pubmed/7011903 PubMed 7016587 http://www.ncbi.nlm.nih.gov/pubmed/7016587 PubMed 7042386 http://www.ncbi.nlm.nih.gov/pubmed/7042386 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_417799 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417799 RefSeq WP_000124700 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000124700 SMART SM00838 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00838 SMART SM00889 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00889 SMR P0A6M8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6M8 STRING 511145.b3340 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3340&targetmode=cogs STRING COG0480 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0480&targetmode=cogs SUPFAM SSF50447 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50447 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SUPFAM SSF54211 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54211 SUPFAM SSF54980 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54980 SWISS-2DPAGE P0A6M8 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A6M8 TIGRFAMs TIGR00231 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00231 TIGRFAMs TIGR00484 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00484 UniProtKB EFG_ECOLI http://www.uniprot.org/uniprot/EFG_ECOLI UniProtKB-AC P0A6M8 http://www.uniprot.org/uniprot/P0A6M8 charge swissprot:EFG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EFG_ECOLI eggNOG COG0480 http://eggnogapi.embl.de/nog_data/html/tree/COG0480 eggNOG ENOG4105CEJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CEJ epestfind swissprot:EFG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EFG_ECOLI garnier swissprot:EFG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EFG_ECOLI helixturnhelix swissprot:EFG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EFG_ECOLI hmoment swissprot:EFG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EFG_ECOLI iep swissprot:EFG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EFG_ECOLI inforesidue swissprot:EFG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EFG_ECOLI octanol swissprot:EFG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EFG_ECOLI pepcoil swissprot:EFG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EFG_ECOLI pepdigest swissprot:EFG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EFG_ECOLI pepinfo swissprot:EFG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EFG_ECOLI pepnet swissprot:EFG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EFG_ECOLI pepstats swissprot:EFG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EFG_ECOLI pepwheel swissprot:EFG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EFG_ECOLI pepwindow swissprot:EFG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EFG_ECOLI sigcleave swissprot:EFG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EFG_ECOLI ## Database ID URL or Descriptions # BioGrid 4260286 10 # CATALYTIC ACTIVITY BTUE_ECOLI 2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH. {ECO 0000255|HAMAP-Rule MF_02061, ECO 0000269|PubMed 20621065}. # CATALYTIC ACTIVITY BTUE_ECOLI 2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O. {ECO 0000255|HAMAP-Rule MF_02061, ECO 0000269|PubMed 20621065}. # CAUTION BTUE_ECOLI Part of the btuCED operon, and was originally thought to participate in the transport of vitamin B12, but it was shown later that it plays no essential role in vitamin B12 transport. {ECO 0000305|PubMed 2671656, ECO 0000305|PubMed 3528129}. # CDD cd00340 GSH_Peroxidase # DISRUPTION PHENOTYPE Deletion has no significant effect on the binding, transport or utilization of vitamin B12 or other cobalamins. {ECO:0000269|PubMed 2671656}. # EcoGene EG10129 btuE # FUNCTION BTUE_ECOLI Non-specific peroxidase that can use thioredoxin or glutathione as a reducing agent. In vitro, utilizes preferentially thioredoxin A to decompose hydrogen peroxide as well as cumene-, tert-butyl-, and linoleic acid hydroperoxides, suggesting that it may have one or more organic hydroperoxide as its physiological substrate. {ECO 0000269|PubMed 20621065}. # GO_component GO:0042597 periplasmic space; IDA:EcoliWiki. # GO_function GO:0004602 glutathione peroxidase activity; IDA:EcoCyc. # GO_function GO:0008379 thioredoxin peroxidase activity; IDA:EcoCyc. # GO_process GO:0033194 response to hydroperoxide; IEP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006950 response to stress # Gene3D 3.40.30.10 -; 1. # HAMAP MF_02061 Thiored_glutath_peroxid # INDUCTION Induced by oxidative stress conditions. {ECO:0000269|PubMed 20621065}. # IntAct P06610 17 # InterPro IPR000889 Glutathione_peroxidase # InterPro IPR012336 Thioredoxin-like_fold # InterPro IPR029759 GPX_AS # InterPro IPR029760 GPX_CS # InterPro IPR033674 BtuE # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00480 Glutathione metabolism # KEGG_Pathway ko00590 Arachidonic acid metabolism # Organism BTUE_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11592 PTHR11592 # PATRIC 32118726 VBIEscCol129921_1781 # PIR F64929 QRECBE # PIRSF PIRSF000303 Glutathion_perox # PRINTS PR01011 GLUTPROXDASE # PROSITE PS00460 GLUTATHIONE_PEROXID_1 # PROSITE PS00763 GLUTATHIONE_PEROXID_2 # PROSITE PS51355 GLUTATHIONE_PEROXID_3 # PeroxiBase 3987 EcoGPx01 # Pfam PF00255 GSHPx # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Thioredoxin/glutathione peroxidase BtuE {ECO:0000255|HAMAP-Rule MF_02061, ECO:0000305} # RefSeq NP_416225 NC_000913.3 # RefSeq WP_001154168 NZ_LN832404.1 # SIMILARITY Belongs to the glutathione peroxidase family. BtuE subfamily. {ECO:0000255|HAMAP-Rule MF_02061}. # SUBCELLULAR LOCATION BTUE_ECOLI Periplasm {ECO 0000305|PubMed 3528129}. Note=Appears to have a periplasmic location. It has the mean hydropathy of a soluble protein but lacks an obvious signal sequence. {ECO 0000305|PubMed 3528129}. # SUPFAM SSF52833 SSF52833 # eggNOG COG0386 LUCA # eggNOG ENOG4108V06 Bacteria BLAST swissprot:BTUE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BTUE_ECOLI BioCyc ECOL316407:JW1700-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1700-MONOMER BioCyc EcoCyc:BTUE-MONOMER http://biocyc.org/getid?id=EcoCyc:BTUE-MONOMER BioCyc MetaCyc:BTUE-MONOMER http://biocyc.org/getid?id=MetaCyc:BTUE-MONOMER COG COG0386 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0386 DOI 10.1007/BF02464897 http://dx.doi.org/10.1007/BF02464897 DOI 10.1016/j.bbrc.2010.07.002 http://dx.doi.org/10.1016/j.bbrc.2010.07.002 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.11.1.15 {ECO:0000255|HAMAP-Rule:MF_02061, ECO:0000269|PubMed:20621065} http://www.genome.jp/dbget-bin/www_bget?EC:1.11.1.15 {ECO:0000255|HAMAP-Rule:MF_02061, ECO:0000269|PubMed:20621065} EC_number EC:1.11.1.9 {ECO:0000255|HAMAP-Rule:MF_02061, ECO:0000269|PubMed:20621065} http://www.genome.jp/dbget-bin/www_bget?EC:1.11.1.9 {ECO:0000255|HAMAP-Rule:MF_02061, ECO:0000269|PubMed:20621065} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M14031 http://www.ebi.ac.uk/ena/data/view/M14031 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.11.1.15 {ECO:0000255|HAMAP-Rule:MF_02061, ECO:0000269|PubMed:20621065} http://enzyme.expasy.org/EC/1.11.1.15 {ECO:0000255|HAMAP-Rule:MF_02061, ECO:0000269|PubMed:20621065} ENZYME 1.11.1.9 {ECO:0000255|HAMAP-Rule:MF_02061, ECO:0000269|PubMed:20621065} http://enzyme.expasy.org/EC/1.11.1.9 {ECO:0000255|HAMAP-Rule:MF_02061, ECO:0000269|PubMed:20621065} EchoBASE EB0127 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0127 EcoGene EG10129 http://www.ecogene.org/geneInfo.php?eg_id=EG10129 EnsemblBacteria AAC74780 http://www.ensemblgenomes.org/id/AAC74780 EnsemblBacteria AAC74780 http://www.ensemblgenomes.org/id/AAC74780 EnsemblBacteria BAA15478 http://www.ensemblgenomes.org/id/BAA15478 EnsemblBacteria BAA15478 http://www.ensemblgenomes.org/id/BAA15478 EnsemblBacteria BAA15478 http://www.ensemblgenomes.org/id/BAA15478 EnsemblBacteria b1710 http://www.ensemblgenomes.org/id/b1710 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0004602 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004602 GO_function GO:0008379 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008379 GO_process GO:0033194 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033194 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.40.30.10 http://www.cathdb.info/version/latest/superfamily/3.40.30.10 GeneID 945915 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945915 HAMAP MF_02061 http://hamap.expasy.org/unirule/MF_02061 HOGENOM HOG000277053 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000277053&db=HOGENOM6 InParanoid P06610 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P06610 IntAct P06610 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P06610* IntEnz 1.11.1.15 {ECO:0000255|HAMAP-Rule:MF_02061, ECO:0000269|PubMed:20621065} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.11.1.15 {ECO:0000255|HAMAP-Rule:MF_02061, ECO:0000269|PubMed:20621065} IntEnz 1.11.1.9 {ECO:0000255|HAMAP-Rule:MF_02061, ECO:0000269|PubMed:20621065} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.11.1.9 {ECO:0000255|HAMAP-Rule:MF_02061, ECO:0000269|PubMed:20621065} InterPro IPR000889 http://www.ebi.ac.uk/interpro/entry/IPR000889 InterPro IPR012336 http://www.ebi.ac.uk/interpro/entry/IPR012336 InterPro IPR029759 http://www.ebi.ac.uk/interpro/entry/IPR029759 InterPro IPR029760 http://www.ebi.ac.uk/interpro/entry/IPR029760 InterPro IPR033674 http://www.ebi.ac.uk/interpro/entry/IPR033674 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1700 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1700 KEGG_Gene eco:b1710 http://www.genome.jp/dbget-bin/www_bget?eco:b1710 KEGG_Orthology KO:K00432 http://www.genome.jp/dbget-bin/www_bget?KO:K00432 KEGG_Pathway ko00480 http://www.genome.jp/kegg-bin/show_pathway?ko00480 KEGG_Pathway ko00590 http://www.genome.jp/kegg-bin/show_pathway?ko00590 KEGG_Reaction rn:R00274 http://www.genome.jp/dbget-bin/www_bget?rn:R00274 KEGG_Reaction rn:R07034 http://www.genome.jp/dbget-bin/www_bget?rn:R07034 KEGG_Reaction rn:R07035 http://www.genome.jp/dbget-bin/www_bget?rn:R07035 OMA SEFYERR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SEFYERR PANTHER PTHR11592 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11592 PRINTS PR01011 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01011 PROSITE PS00460 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00460 PROSITE PS00763 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00763 PROSITE PS51355 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51355 PSORT swissprot:BTUE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BTUE_ECOLI PSORT-B swissprot:BTUE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BTUE_ECOLI PSORT2 swissprot:BTUE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BTUE_ECOLI PeroxiBase 3987 http://peroxibase.toulouse.inra.fr/listing.php?action=view&id=3987 Pfam PF00255 http://pfam.xfam.org/family/PF00255 Phobius swissprot:BTUE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BTUE_ECOLI PhylomeDB P06610 http://phylomedb.org/?seqid=P06610 ProteinModelPortal P06610 http://www.proteinmodelportal.org/query/uniprot/P06610 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20621065 http://www.ncbi.nlm.nih.gov/pubmed/20621065 PubMed 2671656 http://www.ncbi.nlm.nih.gov/pubmed/2671656 PubMed 3528129 http://www.ncbi.nlm.nih.gov/pubmed/3528129 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416225 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416225 RefSeq WP_001154168 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001154168 SMR P06610 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P06610 STRING 511145.b1710 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1710&targetmode=cogs STRING COG0386 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0386&targetmode=cogs SUPFAM SSF52833 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52833 UniProtKB BTUE_ECOLI http://www.uniprot.org/uniprot/BTUE_ECOLI UniProtKB-AC P06610 http://www.uniprot.org/uniprot/P06610 charge swissprot:BTUE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BTUE_ECOLI eggNOG COG0386 http://eggnogapi.embl.de/nog_data/html/tree/COG0386 eggNOG ENOG4108V06 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108V06 epestfind swissprot:BTUE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BTUE_ECOLI garnier swissprot:BTUE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BTUE_ECOLI helixturnhelix swissprot:BTUE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BTUE_ECOLI hmoment swissprot:BTUE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BTUE_ECOLI iep swissprot:BTUE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BTUE_ECOLI inforesidue swissprot:BTUE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BTUE_ECOLI octanol swissprot:BTUE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BTUE_ECOLI pepcoil swissprot:BTUE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BTUE_ECOLI pepdigest swissprot:BTUE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BTUE_ECOLI pepinfo swissprot:BTUE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BTUE_ECOLI pepnet swissprot:BTUE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BTUE_ECOLI pepstats swissprot:BTUE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BTUE_ECOLI pepwheel swissprot:BTUE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BTUE_ECOLI pepwindow swissprot:BTUE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BTUE_ECOLI sigcleave swissprot:BTUE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BTUE_ECOLI ## Database ID URL or Descriptions # AltName FRDC_ECOLI Fumarate reductase 15 kDa hydrophobic protein # BioGrid 4262700 357 # CDD cd00546 QFR_TypeD_subunitC # EcoGene EG10332 frdC # FUNCTION FRDC_ECOLI Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_component GO:0045284 plasma membrane fumarate reductase complex; IDA:EcoCyc. # GO_function GO:0000104 succinate dehydrogenase activity; IDA:EcoCyc. # GO_function GO:0008177 succinate dehydrogenase (ubiquinone) activity; IMP:EcoCyc. # GO_process GO:0006113 fermentation; IMP:EcoCyc. # GO_process GO:0009061 anaerobic respiration; IMP:EcoCyc. # GO_process GO:0044780 bacterial-type flagellum assembly; IMP:EcoCyc. # GO_process GO:0071973 bacterial-type flagellum-dependent cell motility; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0048870 cell motility # HAMAP MF_00708 Fumarate_red_C # IntAct P0A8Q0 3 # InterPro IPR003510 Fumarate_red_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Pathway ko00020 Citrate cycle (TCA cycle) # KEGG_Pathway ko00190 Oxidative phosphorylation # KEGG_Pathway ko00623 Toluene degradation # KEGG_Pathway ko00650 Butanoate metabolism # KEGG_Pathway ko00720 Carbon fixation pathways in prokaryotes # KEGG_Pathway ko02020 Two-component system # Organism FRDC_ECOLI Escherichia coli (strain K12) # PATRIC 32123877 VBIEscCol129921_4286 # PDB 1KF6 X-ray; 2.70 A; C/O=2-131 # PDB 1KFY X-ray; 3.60 A; C/O=2-131 # PDB 1L0V X-ray; 3.30 A; C/O=2-131 # PDB 2B76 X-ray; 3.30 A; C/O=2-131 # PDB 3CIR X-ray; 3.65 A; C/O=2-131 # PDB 3P4P X-ray; 2.80 A; C/O=2-131 # PDB 3P4Q X-ray; 3.35 A; C/O=2-131 # PDB 3P4R X-ray; 3.05 A; C/O=2-131 # PDB 3P4S X-ray; 3.10 A; C/O=2-131 # PIR S56380 S56380 # PIRSF PIRSF000180 FrdC # Pfam PF02300 Fumarate_red_C # ProDom PD015900 Fumarate_red_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FRDC_ECOLI Fumarate reductase subunit C # RefSeq NP_418576 NC_000913.3 # RefSeq WP_000208757 NZ_LN832404.1 # SIMILARITY Belongs to the FrdC family. {ECO 0000305}. # SUBCELLULAR LOCATION FRDC_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT Part of an enzyme complex containing four subunits a flavoprotein (FrdA), an iron-sulfur protein (FrdB), and two hydrophobic anchor proteins (FrdC and FrdD). # eggNOG COG3029 LUCA # eggNOG ENOG4108WJH Bacteria BLAST swissprot:FRDC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FRDC_ECOLI BioCyc ECOL316407:JW4113-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4113-MONOMER BioCyc EcoCyc:FUM-MEMB1 http://biocyc.org/getid?id=EcoCyc:FUM-MEMB1 BioCyc MetaCyc:FUM-MEMB1 http://biocyc.org/getid?id=MetaCyc:FUM-MEMB1 COG COG3029 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3029 DIP DIP-48082N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48082N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.79.4.1111 http://dx.doi.org/10.1073/pnas.79.4.1111 DOI 10.1073/pnas.96.22.12412 http://dx.doi.org/10.1073/pnas.96.22.12412 DOI 10.1074/jbc.M200815200 http://dx.doi.org/10.1074/jbc.M200815200 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1126/science.284.5422.1961 http://dx.doi.org/10.1126/science.284.5422.1961 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01611 http://www.ebi.ac.uk/ena/data/view/J01611 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL V00277 http://www.ebi.ac.uk/ena/data/view/V00277 EchoBASE EB0328 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0328 EcoGene EG10332 http://www.ecogene.org/geneInfo.php?eg_id=EG10332 EnsemblBacteria AAC77112 http://www.ensemblgenomes.org/id/AAC77112 EnsemblBacteria AAC77112 http://www.ensemblgenomes.org/id/AAC77112 EnsemblBacteria BAE78156 http://www.ensemblgenomes.org/id/BAE78156 EnsemblBacteria BAE78156 http://www.ensemblgenomes.org/id/BAE78156 EnsemblBacteria BAE78156 http://www.ensemblgenomes.org/id/BAE78156 EnsemblBacteria b4152 http://www.ensemblgenomes.org/id/b4152 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0045284 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045284 GO_function GO:0000104 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000104 GO_function GO:0008177 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008177 GO_process GO:0006113 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006113 GO_process GO:0009061 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009061 GO_process GO:0044780 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044780 GO_process GO:0071973 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071973 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 GeneID 948680 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948680 HAMAP MF_00708 http://hamap.expasy.org/unirule/MF_00708 HOGENOM HOG000281484 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000281484&db=HOGENOM6 InParanoid P0A8Q0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8Q0 IntAct P0A8Q0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8Q0* InterPro IPR003510 http://www.ebi.ac.uk/interpro/entry/IPR003510 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Gene ecj:JW4113 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4113 KEGG_Gene eco:b4152 http://www.genome.jp/dbget-bin/www_bget?eco:b4152 KEGG_Orthology KO:K00246 http://www.genome.jp/dbget-bin/www_bget?KO:K00246 KEGG_Pathway ko00020 http://www.genome.jp/kegg-bin/show_pathway?ko00020 KEGG_Pathway ko00190 http://www.genome.jp/kegg-bin/show_pathway?ko00190 KEGG_Pathway ko00623 http://www.genome.jp/kegg-bin/show_pathway?ko00623 KEGG_Pathway ko00650 http://www.genome.jp/kegg-bin/show_pathway?ko00650 KEGG_Pathway ko00720 http://www.genome.jp/kegg-bin/show_pathway?ko00720 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 KEGG_Reaction rn:R00408 http://www.genome.jp/dbget-bin/www_bget?rn:R00408 KEGG_Reaction rn:R00412 http://www.genome.jp/dbget-bin/www_bget?rn:R00412 MINT MINT-1290104 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1290104 OMA MTATWWQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MTATWWQ PDB 1KF6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1KF6 PDB 1KFY http://www.ebi.ac.uk/pdbe-srv/view/entry/1KFY PDB 1L0V http://www.ebi.ac.uk/pdbe-srv/view/entry/1L0V PDB 2B76 http://www.ebi.ac.uk/pdbe-srv/view/entry/2B76 PDB 3CIR http://www.ebi.ac.uk/pdbe-srv/view/entry/3CIR PDB 3P4P http://www.ebi.ac.uk/pdbe-srv/view/entry/3P4P PDB 3P4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/3P4Q PDB 3P4R http://www.ebi.ac.uk/pdbe-srv/view/entry/3P4R PDB 3P4S http://www.ebi.ac.uk/pdbe-srv/view/entry/3P4S PDBsum 1KF6 http://www.ebi.ac.uk/pdbsum/1KF6 PDBsum 1KFY http://www.ebi.ac.uk/pdbsum/1KFY PDBsum 1L0V http://www.ebi.ac.uk/pdbsum/1L0V PDBsum 2B76 http://www.ebi.ac.uk/pdbsum/2B76 PDBsum 3CIR http://www.ebi.ac.uk/pdbsum/3CIR PDBsum 3P4P http://www.ebi.ac.uk/pdbsum/3P4P PDBsum 3P4Q http://www.ebi.ac.uk/pdbsum/3P4Q PDBsum 3P4R http://www.ebi.ac.uk/pdbsum/3P4R PDBsum 3P4S http://www.ebi.ac.uk/pdbsum/3P4S PSORT swissprot:FRDC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FRDC_ECOLI PSORT-B swissprot:FRDC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FRDC_ECOLI PSORT2 swissprot:FRDC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FRDC_ECOLI Pfam PF02300 http://pfam.xfam.org/family/PF02300 Phobius swissprot:FRDC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FRDC_ECOLI ProteinModelPortal P0A8Q0 http://www.proteinmodelportal.org/query/uniprot/P0A8Q0 PubMed 10373108 http://www.ncbi.nlm.nih.gov/pubmed/10373108 PubMed 10535936 http://www.ncbi.nlm.nih.gov/pubmed/10535936 PubMed 11850430 http://www.ncbi.nlm.nih.gov/pubmed/11850430 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7041115 http://www.ncbi.nlm.nih.gov/pubmed/7041115 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418576 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418576 RefSeq WP_000208757 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000208757 SMR P0A8Q0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8Q0 STRING 511145.b4152 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4152&targetmode=cogs STRING COG3029 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3029&targetmode=cogs UniProtKB FRDC_ECOLI http://www.uniprot.org/uniprot/FRDC_ECOLI UniProtKB-AC P0A8Q0 http://www.uniprot.org/uniprot/P0A8Q0 charge swissprot:FRDC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FRDC_ECOLI eggNOG COG3029 http://eggnogapi.embl.de/nog_data/html/tree/COG3029 eggNOG ENOG4108WJH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108WJH epestfind swissprot:FRDC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FRDC_ECOLI garnier swissprot:FRDC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FRDC_ECOLI helixturnhelix swissprot:FRDC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FRDC_ECOLI hmoment swissprot:FRDC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FRDC_ECOLI iep swissprot:FRDC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FRDC_ECOLI inforesidue swissprot:FRDC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FRDC_ECOLI octanol swissprot:FRDC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FRDC_ECOLI pepcoil swissprot:FRDC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FRDC_ECOLI pepdigest swissprot:FRDC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FRDC_ECOLI pepinfo swissprot:FRDC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FRDC_ECOLI pepnet swissprot:FRDC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FRDC_ECOLI pepstats swissprot:FRDC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FRDC_ECOLI pepwheel swissprot:FRDC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FRDC_ECOLI pepwindow swissprot:FRDC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FRDC_ECOLI sigcleave swissprot:FRDC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FRDC_ECOLI ## Database ID URL or Descriptions # BRENDA 2.3.1.129 2026 # BioGrid 4261091 384 # CATALYTIC ACTIVITY (R)-3-hydroxytetradecanoyl-[acyl-carrier- protein] + UDP-N-acetyl-alpha-D-glucosamine = [acyl-carrier- protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetyl-alpha-D- glucosamine. {ECO:0000255|HAMAP-Rule MF_00387}. # CDD cd03351 LbH_UDP-GlcNAc_AT # EcoGene EG10545 lpxA # FUNCTION LPXA_ECOLI Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008780 acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity; IDA:EcoliWiki. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0009245 lipid A biosynthetic process; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 1.20.1180.10 -; 1. # HAMAP MF_00387 LpxA # IntAct P0A722 36 # InterPro IPR001451 Hexapep # InterPro IPR010137 Lipid_A_LpxA # InterPro IPR011004 Trimer_LpxA-like # InterPro IPR018357 Hexapep_transf_CS # InterPro IPR029098 Acetyltransf_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # KEGG_Pathway ko00540 Lipopolysaccharide biosynthesis # Organism LPXA_ECOLI Escherichia coli (strain K12) # PATHWAY Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 1/6. {ECO 0000255|HAMAP- Rule:MF_00387}. # PATRIC 32115473 VBIEscCol129921_0188 # PDB 1LXA X-ray; 2.60 A; A=1-262 # PDB 2AQ9 X-ray; 1.80 A; A=1-262 # PDB 2JF2 X-ray; 1.80 A; A=1-262 # PDB 2JF3 X-ray; 3.00 A; A=1-262 # PDB 2QIA X-ray; 1.74 A; A=1-262 # PDB 2QIV X-ray; 1.85 A; X=1-262 # PDB 4J09 X-ray; 1.90 A; A=1-262 # PIR E64742 XUECDP # PIRSF PIRSF000456 UDP-GlcNAc_acltr # PROSITE PS00101 HEXAPEP_TRANSFERASES; 2 # Pfam PF00132 Hexapep; 2 # Pfam PF13720 Acetyltransf_11 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase {ECO:0000255|HAMAP-Rule MF_00387} # RefSeq NP_414723 NC_000913.3 # RefSeq WP_000565966 NZ_LN832404.1 # SIMILARITY Belongs to the transferase hexapeptide repeat family. LpxA subfamily. {ECO:0000255|HAMAP-Rule MF_00387}. # SUBCELLULAR LOCATION LPXA_ECOLI Cytoplasm. # SUBUNIT LPXA_ECOLI Homotrimer. {ECO 0000255|HAMAP-Rule MF_00387, ECO 0000269|PubMed 16835299, ECO 0000269|PubMed 17434525, ECO 0000269|PubMed 17698807}. # SUPFAM SSF51161 SSF51161 # TIGRFAMs TIGR01852 lipid_A_lpxA # UniPathway UPA00359 UER00477 # eggNOG COG1043 LUCA # eggNOG ENOG4105DAF Bacteria BLAST swissprot:LPXA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LPXA_ECOLI BioCyc ECOL316407:JW0176-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0176-MONOMER BioCyc EcoCyc:UDPNACETYLGLUCOSAMACYLTRANS-MONOMER http://biocyc.org/getid?id=EcoCyc:UDPNACETYLGLUCOSAMACYLTRANS-MONOMER BioCyc MetaCyc:UDPNACETYLGLUCOSAMACYLTRANS-MONOMER http://biocyc.org/getid?id=MetaCyc:UDPNACETYLGLUCOSAMACYLTRANS-MONOMER COG COG1043 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1043 DIP DIP-48043N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48043N DOI 10.1016/j.jmb.2007.03.039 http://dx.doi.org/10.1016/j.jmb.2007.03.039 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0604465103 http://dx.doi.org/10.1073/pnas.0604465103 DOI 10.1073/pnas.0705833104 http://dx.doi.org/10.1073/pnas.0705833104 DOI 10.1126/science.270.5238.997 http://dx.doi.org/10.1126/science.270.5238.997 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.129 {ECO:0000255|HAMAP-Rule:MF_00387} http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.129 {ECO:0000255|HAMAP-Rule:MF_00387} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M19334 http://www.ebi.ac.uk/ena/data/view/M19334 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 ENZYME 2.3.1.129 {ECO:0000255|HAMAP-Rule:MF_00387} http://enzyme.expasy.org/EC/2.3.1.129 {ECO:0000255|HAMAP-Rule:MF_00387} EchoBASE EB0540 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0540 EcoGene EG10545 http://www.ecogene.org/geneInfo.php?eg_id=EG10545 EnsemblBacteria AAC73292 http://www.ensemblgenomes.org/id/AAC73292 EnsemblBacteria AAC73292 http://www.ensemblgenomes.org/id/AAC73292 EnsemblBacteria BAA77856 http://www.ensemblgenomes.org/id/BAA77856 EnsemblBacteria BAA77856 http://www.ensemblgenomes.org/id/BAA77856 EnsemblBacteria BAA77856 http://www.ensemblgenomes.org/id/BAA77856 EnsemblBacteria b0181 http://www.ensemblgenomes.org/id/b0181 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008780 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008780 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0009245 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009245 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 1.20.1180.10 http://www.cathdb.info/version/latest/superfamily/1.20.1180.10 GeneID 944849 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944849 HAMAP MF_00387 http://hamap.expasy.org/unirule/MF_00387 HOGENOM HOG000294326 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000294326&db=HOGENOM6 InParanoid P0A722 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A722 IntAct P0A722 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A722* IntEnz 2.3.1.129 {ECO:0000255|HAMAP-Rule:MF_00387} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.129 {ECO:0000255|HAMAP-Rule:MF_00387} InterPro IPR001451 http://www.ebi.ac.uk/interpro/entry/IPR001451 InterPro IPR010137 http://www.ebi.ac.uk/interpro/entry/IPR010137 InterPro IPR011004 http://www.ebi.ac.uk/interpro/entry/IPR011004 InterPro IPR018357 http://www.ebi.ac.uk/interpro/entry/IPR018357 InterPro IPR029098 http://www.ebi.ac.uk/interpro/entry/IPR029098 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Gene ecj:JW0176 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0176 KEGG_Gene eco:b0181 http://www.genome.jp/dbget-bin/www_bget?eco:b0181 KEGG_Orthology KO:K00677 http://www.genome.jp/dbget-bin/www_bget?KO:K00677 KEGG_Pathway ko00540 http://www.genome.jp/kegg-bin/show_pathway?ko00540 KEGG_Reaction rn:R04567 http://www.genome.jp/dbget-bin/www_bget?rn:R04567 MINT MINT-1234984 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1234984 OMA GDDGLFM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GDDGLFM PDB 1LXA http://www.ebi.ac.uk/pdbe-srv/view/entry/1LXA PDB 2AQ9 http://www.ebi.ac.uk/pdbe-srv/view/entry/2AQ9 PDB 2JF2 http://www.ebi.ac.uk/pdbe-srv/view/entry/2JF2 PDB 2JF3 http://www.ebi.ac.uk/pdbe-srv/view/entry/2JF3 PDB 2QIA http://www.ebi.ac.uk/pdbe-srv/view/entry/2QIA PDB 2QIV http://www.ebi.ac.uk/pdbe-srv/view/entry/2QIV PDB 4J09 http://www.ebi.ac.uk/pdbe-srv/view/entry/4J09 PDBsum 1LXA http://www.ebi.ac.uk/pdbsum/1LXA PDBsum 2AQ9 http://www.ebi.ac.uk/pdbsum/2AQ9 PDBsum 2JF2 http://www.ebi.ac.uk/pdbsum/2JF2 PDBsum 2JF3 http://www.ebi.ac.uk/pdbsum/2JF3 PDBsum 2QIA http://www.ebi.ac.uk/pdbsum/2QIA PDBsum 2QIV http://www.ebi.ac.uk/pdbsum/2QIV PDBsum 4J09 http://www.ebi.ac.uk/pdbsum/4J09 PROSITE PS00101 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00101 PSORT swissprot:LPXA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LPXA_ECOLI PSORT-B swissprot:LPXA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LPXA_ECOLI PSORT2 swissprot:LPXA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LPXA_ECOLI Pfam PF00132 http://pfam.xfam.org/family/PF00132 Pfam PF13720 http://pfam.xfam.org/family/PF13720 Phobius swissprot:LPXA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LPXA_ECOLI PhylomeDB P0A722 http://phylomedb.org/?seqid=P0A722 ProteinModelPortal P0A722 http://www.proteinmodelportal.org/query/uniprot/P0A722 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16835299 http://www.ncbi.nlm.nih.gov/pubmed/16835299 PubMed 17434525 http://www.ncbi.nlm.nih.gov/pubmed/17434525 PubMed 17698807 http://www.ncbi.nlm.nih.gov/pubmed/17698807 PubMed 2824445 http://www.ncbi.nlm.nih.gov/pubmed/2824445 PubMed 3277952 http://www.ncbi.nlm.nih.gov/pubmed/3277952 PubMed 7481807 http://www.ncbi.nlm.nih.gov/pubmed/7481807 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414723 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414723 RefSeq WP_000565966 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000565966 SMR P0A722 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A722 STRING 511145.b0181 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0181&targetmode=cogs STRING COG1043 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1043&targetmode=cogs SUPFAM SSF51161 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51161 TIGRFAMs TIGR01852 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01852 UniProtKB LPXA_ECOLI http://www.uniprot.org/uniprot/LPXA_ECOLI UniProtKB-AC P0A722 http://www.uniprot.org/uniprot/P0A722 charge swissprot:LPXA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LPXA_ECOLI eggNOG COG1043 http://eggnogapi.embl.de/nog_data/html/tree/COG1043 eggNOG ENOG4105DAF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DAF epestfind swissprot:LPXA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LPXA_ECOLI garnier swissprot:LPXA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LPXA_ECOLI helixturnhelix swissprot:LPXA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LPXA_ECOLI hmoment swissprot:LPXA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LPXA_ECOLI iep swissprot:LPXA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LPXA_ECOLI inforesidue swissprot:LPXA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LPXA_ECOLI octanol swissprot:LPXA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LPXA_ECOLI pepcoil swissprot:LPXA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LPXA_ECOLI pepdigest swissprot:LPXA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LPXA_ECOLI pepinfo swissprot:LPXA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LPXA_ECOLI pepnet swissprot:LPXA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LPXA_ECOLI pepstats swissprot:LPXA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LPXA_ECOLI pepwheel swissprot:LPXA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LPXA_ECOLI pepwindow swissprot:LPXA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LPXA_ECOLI sigcleave swissprot:LPXA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LPXA_ECOLI ## Database ID URL or Descriptions # AltName DCM_ECOLI M.EcoDcm # BioGrid 4260865 162 # CATALYTIC ACTIVITY S-adenosyl-L-methionine + DNA = S-adenosyl-L- homocysteine + DNA containing 5-methylcytosine. {ECO:0000255|PROSITE-ProRule PRU10018}. # EcoGene EG10211 dcm # FUNCTION DCM_ECOLI This methylase recognizes the double-stranded sequence CCWGG, causes specific methylation on C-2 on both strands. # GO_function GO:0003886 DNA (cytosine-5-)-methyltransferase activity; IDA:EcoCyc. # GO_process GO:0009307 DNA restriction-modification system; IEA:UniProtKB-KW. # GO_process GO:0090116 C-5 methylation of cytosine; IMP:EcoCyc. # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # Gene3D 3.40.50.150 -; 1. # INTERACTION DCM_ECOLI P06959 aceF; NbExp=2; IntAct=EBI-548525, EBI-542707; # IntAct P0AED9 21 # InterPro IPR001525 C5_MeTfrase # InterPro IPR018117 C5_DNA_meth_AS # InterPro IPR029063 SAM-dependent_MTases # InterPro IPR031303 C5_meth_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03032 DNA replication proteins # KEGG_Brite ko03036 Chromosome # KEGG_Pathway ko00270 Cysteine and methionine metabolism # Organism DCM_ECOLI Escherichia coli (strain K12) # PATRIC 32119251 VBIEscCol129921_2040 # PIR A37754 JS0263 # PRINTS PR00105 C5METTRFRASE # PROSITE PS00094 C5_MTASE_1 # PROSITE PS00095 C5_MTASE_2 # PROSITE PS51679 SAM_MT_C5 # Pfam PF00145 DNA_methylase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # REBASE 2397 M.EcoKDcm # RecName DCM_ECOLI DNA-cytosine methyltransferase # RefSeq NP_416470 NC_000913.3 # RefSeq WP_001157239 NZ_LN832404.1 # SIMILARITY Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. {ECO:0000255|PROSITE-ProRule PRU01016}. # SIMILARITY Contains 1 SAM-dependent MTase C5-type domain. {ECO:0000255|PROSITE-ProRule PRU01016}. # SUPFAM SSF53335 SSF53335 # TIGRFAMs TIGR00675 dcm # eggNOG COG0270 LUCA # eggNOG ENOG4105DVF Bacteria BLAST swissprot:DCM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DCM_ECOLI BioCyc ECOL316407:JW1944-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1944-MONOMER BioCyc EcoCyc:EG10211-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10211-MONOMER BioCyc MetaCyc:EG10211-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10211-MONOMER COG COG0270 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0270 DIP DIP-47858N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47858N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/nar/17.14.5844 http://dx.doi.org/10.1093/nar/17.14.5844 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.1.37 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.37 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M32307 http://www.ebi.ac.uk/ena/data/view/M32307 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X13330 http://www.ebi.ac.uk/ena/data/view/X13330 ENZYME 2.1.1.37 http://enzyme.expasy.org/EC/2.1.1.37 EchoBASE EB0207 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0207 EcoGene EG10211 http://www.ecogene.org/geneInfo.php?eg_id=EG10211 EnsemblBacteria AAC75027 http://www.ensemblgenomes.org/id/AAC75027 EnsemblBacteria AAC75027 http://www.ensemblgenomes.org/id/AAC75027 EnsemblBacteria BAA15788 http://www.ensemblgenomes.org/id/BAA15788 EnsemblBacteria BAA15788 http://www.ensemblgenomes.org/id/BAA15788 EnsemblBacteria BAA15788 http://www.ensemblgenomes.org/id/BAA15788 EnsemblBacteria b1961 http://www.ensemblgenomes.org/id/b1961 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003886 GO_process GO:0009307 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009307 GO_process GO:0090116 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090116 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 GeneID 946479 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946479 HOGENOM HOG000225506 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000225506&db=HOGENOM6 InParanoid P0AED9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AED9 IntAct P0AED9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AED9* IntEnz 2.1.1.37 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.37 InterPro IPR001525 http://www.ebi.ac.uk/interpro/entry/IPR001525 InterPro IPR018117 http://www.ebi.ac.uk/interpro/entry/IPR018117 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 InterPro IPR031303 http://www.ebi.ac.uk/interpro/entry/IPR031303 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03032 http://www.genome.jp/dbget-bin/www_bget?ko03032 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene ecj:JW1944 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1944 KEGG_Gene eco:b1961 http://www.genome.jp/dbget-bin/www_bget?eco:b1961 KEGG_Orthology KO:K00558 http://www.genome.jp/dbget-bin/www_bget?KO:K00558 KEGG_Pathway ko00270 http://www.genome.jp/kegg-bin/show_pathway?ko00270 KEGG_Reaction rn:R04858 http://www.genome.jp/dbget-bin/www_bget?rn:R04858 MINT MINT-1237420 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1237420 OMA YLYRYAR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YLYRYAR PRINTS PR00105 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00105 PROSITE PS00094 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00094 PROSITE PS00095 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00095 PROSITE PS51679 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51679 PSORT swissprot:DCM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DCM_ECOLI PSORT-B swissprot:DCM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DCM_ECOLI PSORT2 swissprot:DCM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DCM_ECOLI Pfam PF00145 http://pfam.xfam.org/family/PF00145 Phobius swissprot:DCM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DCM_ECOLI PhylomeDB P0AED9 http://phylomedb.org/?seqid=P0AED9 ProteinModelPortal P0AED9 http://www.proteinmodelportal.org/query/uniprot/P0AED9 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2198248 http://www.ncbi.nlm.nih.gov/pubmed/2198248 PubMed 2527357 http://www.ncbi.nlm.nih.gov/pubmed/2527357 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 REBASE 2397 http://rebase.neb.com/rebase/enz/2397.html RefSeq NP_416470 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416470 RefSeq WP_001157239 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001157239 SMR P0AED9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AED9 STRING 511145.b1961 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1961&targetmode=cogs STRING COG0270 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0270&targetmode=cogs SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 TIGRFAMs TIGR00675 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00675 UniProtKB DCM_ECOLI http://www.uniprot.org/uniprot/DCM_ECOLI UniProtKB-AC P0AED9 http://www.uniprot.org/uniprot/P0AED9 charge swissprot:DCM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DCM_ECOLI eggNOG COG0270 http://eggnogapi.embl.de/nog_data/html/tree/COG0270 eggNOG ENOG4105DVF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DVF epestfind swissprot:DCM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DCM_ECOLI garnier swissprot:DCM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DCM_ECOLI helixturnhelix swissprot:DCM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DCM_ECOLI hmoment swissprot:DCM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DCM_ECOLI iep swissprot:DCM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DCM_ECOLI inforesidue swissprot:DCM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DCM_ECOLI octanol swissprot:DCM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DCM_ECOLI pepcoil swissprot:DCM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DCM_ECOLI pepdigest swissprot:DCM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DCM_ECOLI pepinfo swissprot:DCM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DCM_ECOLI pepnet swissprot:DCM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DCM_ECOLI pepstats swissprot:DCM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DCM_ECOLI pepwheel swissprot:DCM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DCM_ECOLI pepwindow swissprot:DCM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DCM_ECOLI sigcleave swissprot:DCM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DCM_ECOLI ## Database ID URL or Descriptions # AltName RSME_ECOLI 16S rRNA m3U1498 methyltransferase # BIOPHYSICOCHEMICAL PROPERTIES RSME_ECOLI Kinetic parameters KM=2.0 uM for 16S rRNA within 30S ribosomal subunits {ECO 0000269|PubMed 17872509}; KM=26.7 uM for S-adenosyl-L-methionine {ECO 0000269|PubMed 17872509}; pH dependence Optimum pH is 7-9. {ECO 0000269|PubMed 17872509}; # BRENDA 2.1.1.193 2026 # BioGrid 4259407 7 # CATALYTIC ACTIVITY S-adenosyl-L-methionine + uracil(1498) in 16S rRNA = S-adenosyl-L-homocysteine + N(3)-methyluracil(1498) in 16S rRNA. {ECO:0000269|PubMed 16431987}. # EcoGene EG12366 rsmE # FUNCTION RSME_ECOLI Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. {ECO 0000269|PubMed 16431987, ECO 0000269|PubMed 17872509}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0070042 rRNA (uridine-N3-)-methyltransferase activity; IDA:EcoCyc. # GO_process GO:0070475 rRNA base methylation; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.1280.10 -; 1. # IntAct P0AGL7 5 # InterPro IPR006700 rRNA_ssu_MeTrfase-E # InterPro IPR015947 PUA-like_domain # InterPro IPR029026 tRNA_m1G_MTases_N # InterPro IPR029028 Alpha/beta_knot_MTases # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # Organism RSME_ECOLI Escherichia coli (strain K12) # PATRIC 32121302 VBIEscCol129921_3039 # PDB 4E8B X-ray; 2.25 A; A=1-243 # PIRSF PIRSF015601 MTase_slr0722 # Pfam PF04452 Methyltrans_RNA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RSME_ECOLI Ribosomal RNA small subunit methyltransferase E # RefSeq NP_417421 NC_000913.3 # RefSeq WP_001222509 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA69113.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the RNA methyltransferase RsmE family. {ECO 0000305}. # SUBCELLULAR LOCATION RSME_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 17872509}. # SUPFAM SSF75217 SSF75217 # SUPFAM SSF88697 SSF88697 # TIGRFAMs TIGR00046 TIGR00046 # eggNOG COG1385 LUCA # eggNOG ENOG4105QF0 Bacteria BLAST swissprot:RSME_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RSME_ECOLI BioCyc ECOL316407:JW2913-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2913-MONOMER BioCyc EcoCyc:EG12366-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12366-MONOMER BioCyc MetaCyc:EG12366-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12366-MONOMER COG COG1385 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1385 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/12.24.9299 http://dx.doi.org/10.1093/nar/12.24.9299 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1261/rna.2283106 http://dx.doi.org/10.1261/rna.2283106 DOI 10.1261/rna.700507 http://dx.doi.org/10.1261/rna.700507 EC_number EC:2.1.1.193 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.193 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EMBL X01666 http://www.ebi.ac.uk/ena/data/view/X01666 EMBL X65169 http://www.ebi.ac.uk/ena/data/view/X65169 ENZYME 2.1.1.193 http://enzyme.expasy.org/EC/2.1.1.193 EchoBASE EB2269 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2269 EcoGene EG12366 http://www.ecogene.org/geneInfo.php?eg_id=EG12366 EnsemblBacteria AAC75983 http://www.ensemblgenomes.org/id/AAC75983 EnsemblBacteria AAC75983 http://www.ensemblgenomes.org/id/AAC75983 EnsemblBacteria BAE77009 http://www.ensemblgenomes.org/id/BAE77009 EnsemblBacteria BAE77009 http://www.ensemblgenomes.org/id/BAE77009 EnsemblBacteria BAE77009 http://www.ensemblgenomes.org/id/BAE77009 EnsemblBacteria b2946 http://www.ensemblgenomes.org/id/b2946 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0070042 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070042 GO_process GO:0070475 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070475 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.1280.10 http://www.cathdb.info/version/latest/superfamily/3.40.1280.10 GeneID 945816 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945816 HOGENOM HOG000015265 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000015265&db=HOGENOM6 InParanoid P0AGL7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGL7 IntAct P0AGL7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AGL7* IntEnz 2.1.1.193 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.193 InterPro IPR006700 http://www.ebi.ac.uk/interpro/entry/IPR006700 InterPro IPR015947 http://www.ebi.ac.uk/interpro/entry/IPR015947 InterPro IPR029026 http://www.ebi.ac.uk/interpro/entry/IPR029026 InterPro IPR029028 http://www.ebi.ac.uk/interpro/entry/IPR029028 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW2913 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2913 KEGG_Gene eco:b2946 http://www.genome.jp/dbget-bin/www_bget?eco:b2946 KEGG_Orthology KO:K09761 http://www.genome.jp/dbget-bin/www_bget?KO:K09761 OMA ERMEFTI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ERMEFTI PDB 4E8B http://www.ebi.ac.uk/pdbe-srv/view/entry/4E8B PDBsum 4E8B http://www.ebi.ac.uk/pdbsum/4E8B PSORT swissprot:RSME_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RSME_ECOLI PSORT-B swissprot:RSME_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RSME_ECOLI PSORT2 swissprot:RSME_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RSME_ECOLI Pfam PF04452 http://pfam.xfam.org/family/PF04452 Phobius swissprot:RSME_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RSME_ECOLI PhylomeDB P0AGL7 http://phylomedb.org/?seqid=P0AGL7 ProteinModelPortal P0AGL7 http://www.proteinmodelportal.org/query/uniprot/P0AGL7 PubMed 16431987 http://www.ncbi.nlm.nih.gov/pubmed/16431987 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17872509 http://www.ncbi.nlm.nih.gov/pubmed/17872509 PubMed 6393055 http://www.ncbi.nlm.nih.gov/pubmed/6393055 PubMed 8113204 http://www.ncbi.nlm.nih.gov/pubmed/8113204 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417421 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417421 RefSeq WP_001222509 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001222509 SMR P0AGL7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AGL7 STRING 511145.b2946 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2946&targetmode=cogs STRING COG1385 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1385&targetmode=cogs SUPFAM SSF75217 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF75217 SUPFAM SSF88697 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF88697 TIGRFAMs TIGR00046 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00046 UniProtKB RSME_ECOLI http://www.uniprot.org/uniprot/RSME_ECOLI UniProtKB-AC P0AGL7 http://www.uniprot.org/uniprot/P0AGL7 charge swissprot:RSME_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RSME_ECOLI eggNOG COG1385 http://eggnogapi.embl.de/nog_data/html/tree/COG1385 eggNOG ENOG4105QF0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105QF0 epestfind swissprot:RSME_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RSME_ECOLI garnier swissprot:RSME_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RSME_ECOLI helixturnhelix swissprot:RSME_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RSME_ECOLI hmoment swissprot:RSME_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RSME_ECOLI iep swissprot:RSME_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RSME_ECOLI inforesidue swissprot:RSME_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RSME_ECOLI octanol swissprot:RSME_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RSME_ECOLI pepcoil swissprot:RSME_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RSME_ECOLI pepdigest swissprot:RSME_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RSME_ECOLI pepinfo swissprot:RSME_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RSME_ECOLI pepnet swissprot:RSME_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RSME_ECOLI pepstats swissprot:RSME_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RSME_ECOLI pepwheel swissprot:RSME_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RSME_ECOLI pepwindow swissprot:RSME_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RSME_ECOLI sigcleave swissprot:RSME_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RSME_ECOLI ## Database ID URL or Descriptions # AltName PTRA_ECOLI Pitrilysin # AltName PTRA_ECOLI Protease III # AltName PTRA_ECOLI Protease pi # BioGrid 4262308 16 # CATALYTIC ACTIVITY Preferential cleavage of 16-Tyr-|-Leu-17 and 25-Phe-|-Tyr-26 bonds of oxidized insulin B chain. Also acts on other substrates of Mw less than 7 kDa such as insulin and glucagon. {ECO:0000255|PROSITE-ProRule PRU10096}. # COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI 29105; Note=Binds 1 zinc ion per subunit.; # EcoGene EG10786 ptrA # FUNCTION PTRA_ECOLI Endopeptidase that degrades small peptides of less than 7 kDa, such as glucagon and insulin. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0004222 metalloendopeptidase activity; IDA:EcoliWiki. # GO_function GO:0008237 metallopeptidase activity; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IDA:EcoliWiki. # GO_process GO:0006508 proteolysis; IDA:EcoliWiki. # GO_process GO:0016485 protein processing; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0051604 protein maturation # Gene3D 3.30.830.10 -; 4. # IntAct P05458 11 # InterPro IPR001431 Pept_M16_Zn_BS # InterPro IPR007863 Peptidase_M16_C # InterPro IPR011237 Pept_M16_dom # InterPro IPR011249 Metalloenz_LuxS/M16 # InterPro IPR011765 Pept_M16_N # InterPro IPR032632 Peptidase_M16_M # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # Organism PTRA_ECOLI Escherichia coli (strain K12) # PATRIC 32121060 VBIEscCol129921_2919 # PDB 1Q2L X-ray; 2.20 A; A=24-962 # PIR F65064 SNECPI # PROSITE PS00143 INSULINASE # Pfam PF00675 Peptidase_M16 # Pfam PF05193 Peptidase_M16_C; 2 # Pfam PF16187 Peptidase_M16_M # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PTRA_ECOLI Protease 3 # RefSeq NP_417298 NC_000913.3 # RefSeq WP_001138201 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase M16 family. {ECO 0000305}. # SUBCELLULAR LOCATION PTRA_ECOLI Periplasm. # SUBUNIT PTRA_ECOLI Monomer. # SUPFAM SSF63411 SSF63411; 4 # eggNOG COG1025 LUCA # eggNOG ENOG4107QXK Bacteria BLAST swissprot:PTRA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTRA_ECOLI BioCyc ECOL316407:JW2789-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2789-MONOMER BioCyc EcoCyc:EG10786-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10786-MONOMER BioCyc MetaCyc:EG10786-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10786-MONOMER COG COG1025 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1025 DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0378-1119(87)90486-0 http://dx.doi.org/10.1016/0378-1119(87)90486-0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2920137 http://dx.doi.org/10.1042/bj2920137 DOI 10.1073/pnas.89.9.3835 http://dx.doi.org/10.1073/pnas.89.9.3835 DOI 10.1093/nar/14.19.7695 http://dx.doi.org/10.1093/nar/14.19.7695 DOI 10.1093/nar/14.21.8573 http://dx.doi.org/10.1093/nar/14.21.8573 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.24.55 http://www.genome.jp/dbget-bin/www_bget?EC:3.4.24.55 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M17095 http://www.ebi.ac.uk/ena/data/view/M17095 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 EMBL X04581 http://www.ebi.ac.uk/ena/data/view/X04581 EMBL X06227 http://www.ebi.ac.uk/ena/data/view/X06227 ENZYME 3.4.24.55 http://enzyme.expasy.org/EC/3.4.24.55 EchoBASE EB0779 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0779 EcoGene EG10786 http://www.ecogene.org/geneInfo.php?eg_id=EG10786 EnsemblBacteria AAC75860 http://www.ensemblgenomes.org/id/AAC75860 EnsemblBacteria AAC75860 http://www.ensemblgenomes.org/id/AAC75860 EnsemblBacteria BAE76890 http://www.ensemblgenomes.org/id/BAE76890 EnsemblBacteria BAE76890 http://www.ensemblgenomes.org/id/BAE76890 EnsemblBacteria BAE76890 http://www.ensemblgenomes.org/id/BAE76890 EnsemblBacteria b2821 http://www.ensemblgenomes.org/id/b2821 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0004222 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004222 GO_function GO:0008237 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008237 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_process GO:0006508 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006508 GO_process GO:0016485 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016485 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 Gene3D 3.30.830.10 http://www.cathdb.info/version/latest/superfamily/3.30.830.10 GeneID 947284 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947284 HOGENOM HOG000124324 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000124324&db=HOGENOM6 InParanoid P05458 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P05458 IntAct P05458 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P05458* IntEnz 3.4.24.55 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.24.55 InterPro IPR001431 http://www.ebi.ac.uk/interpro/entry/IPR001431 InterPro IPR007863 http://www.ebi.ac.uk/interpro/entry/IPR007863 InterPro IPR011237 http://www.ebi.ac.uk/interpro/entry/IPR011237 InterPro IPR011249 http://www.ebi.ac.uk/interpro/entry/IPR011249 InterPro IPR011765 http://www.ebi.ac.uk/interpro/entry/IPR011765 InterPro IPR032632 http://www.ebi.ac.uk/interpro/entry/IPR032632 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW2789 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2789 KEGG_Gene eco:b2821 http://www.genome.jp/dbget-bin/www_bget?eco:b2821 KEGG_Orthology KO:K01407 http://www.genome.jp/dbget-bin/www_bget?KO:K01407 OMA GYTQHLP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GYTQHLP PDB 1Q2L http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q2L PDBsum 1Q2L http://www.ebi.ac.uk/pdbsum/1Q2L PROSITE PS00143 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00143 PSORT swissprot:PTRA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTRA_ECOLI PSORT-B swissprot:PTRA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTRA_ECOLI PSORT2 swissprot:PTRA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTRA_ECOLI Pfam PF00675 http://pfam.xfam.org/family/PF00675 Pfam PF05193 http://pfam.xfam.org/family/PF05193 Pfam PF16187 http://pfam.xfam.org/family/PF16187 Phobius swissprot:PTRA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTRA_ECOLI PhylomeDB P05458 http://phylomedb.org/?seqid=P05458 ProteinModelPortal P05458 http://www.proteinmodelportal.org/query/uniprot/P05458 PubMed 1570301 http://www.ncbi.nlm.nih.gov/pubmed/1570301 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3308636 http://www.ncbi.nlm.nih.gov/pubmed/3308636 PubMed 3534791 http://www.ncbi.nlm.nih.gov/pubmed/3534791 PubMed 3537960 http://www.ncbi.nlm.nih.gov/pubmed/3537960 PubMed 8099278 http://www.ncbi.nlm.nih.gov/pubmed/8099278 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417298 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417298 RefSeq WP_001138201 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001138201 SMR P05458 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P05458 STRING 511145.b2821 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2821&targetmode=cogs STRING COG1025 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1025&targetmode=cogs SUPFAM SSF63411 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63411 UniProtKB PTRA_ECOLI http://www.uniprot.org/uniprot/PTRA_ECOLI UniProtKB-AC P05458 http://www.uniprot.org/uniprot/P05458 charge swissprot:PTRA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTRA_ECOLI eggNOG COG1025 http://eggnogapi.embl.de/nog_data/html/tree/COG1025 eggNOG ENOG4107QXK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QXK epestfind swissprot:PTRA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTRA_ECOLI garnier swissprot:PTRA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTRA_ECOLI helixturnhelix swissprot:PTRA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTRA_ECOLI hmoment swissprot:PTRA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTRA_ECOLI iep swissprot:PTRA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTRA_ECOLI inforesidue swissprot:PTRA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTRA_ECOLI octanol swissprot:PTRA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTRA_ECOLI pepcoil swissprot:PTRA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTRA_ECOLI pepdigest swissprot:PTRA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTRA_ECOLI pepinfo swissprot:PTRA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTRA_ECOLI pepnet swissprot:PTRA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTRA_ECOLI pepstats swissprot:PTRA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTRA_ECOLI pepwheel swissprot:PTRA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTRA_ECOLI pepwindow swissprot:PTRA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTRA_ECOLI sigcleave swissprot:PTRA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTRA_ECOLI ## Database ID URL or Descriptions # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG11611 ychG # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # IntAct P30192 5 # InterPro IPR002559 Transposase_11 # InterPro IPR012337 RNaseH-like_dom # InterPro IPR024473 Transposases_IS4_N # Organism YCHG_ECOLI Escherichia coli (strain K12) # PIR C64871 C64871 # PIR I76912 I76912 # Pfam PF01609 DDE_Tnp_1 # Pfam PF13006 Nterm_IS4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCHG_ECOLI Putative uncharacterized protein YchG # SEQUENCE CAUTION Sequence=AP009048; Type=Frameshift; Positions=62, 112; Evidence={ECO:0000305}; Sequence=CAA47742.1; Type=Frameshift; Positions=62, 112; Evidence={ECO 0000305}; Sequence=U00096; Type=Frameshift; Positions=62, 112; Evidence={ECO:0000305}; # SUPFAM SSF53098 SSF53098 BLAST swissprot:YCHG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCHG_ECOLI BioCyc EcoCyc:EG11611-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11611-MONOMER BioCyc EcoCyc:G6632-MONOMER http://biocyc.org/getid?id=EcoCyc:G6632-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1099/13500872-141-4-959 http://dx.doi.org/10.1099/13500872-141-4-959 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X67326 http://www.ebi.ac.uk/ena/data/view/X67326 EchoBASE EB1568 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1568 EcoGene EG11611 http://www.ecogene.org/geneInfo.php?eg_id=EG11611 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 HOGENOM HOG000119822 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000119822&db=HOGENOM6 InParanoid P30192 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30192 IntAct P30192 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P30192* InterPro IPR002559 http://www.ebi.ac.uk/interpro/entry/IPR002559 InterPro IPR012337 http://www.ebi.ac.uk/interpro/entry/IPR012337 InterPro IPR024473 http://www.ebi.ac.uk/interpro/entry/IPR024473 OMA RNIPVEW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RNIPVEW PSORT swissprot:YCHG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCHG_ECOLI PSORT-B swissprot:YCHG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCHG_ECOLI PSORT2 swissprot:YCHG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCHG_ECOLI Pfam PF01609 http://pfam.xfam.org/family/PF01609 Pfam PF13006 http://pfam.xfam.org/family/PF13006 Phobius swissprot:YCHG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCHG_ECOLI PhylomeDB P30192 http://phylomedb.org/?seqid=P30192 ProteinModelPortal P30192 http://www.proteinmodelportal.org/query/uniprot/P30192 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7773397 http://www.ncbi.nlm.nih.gov/pubmed/7773397 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SUPFAM SSF53098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098 UniProtKB YCHG_ECOLI http://www.uniprot.org/uniprot/YCHG_ECOLI UniProtKB-AC P30192 http://www.uniprot.org/uniprot/P30192 charge swissprot:YCHG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCHG_ECOLI epestfind swissprot:YCHG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCHG_ECOLI garnier swissprot:YCHG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCHG_ECOLI helixturnhelix swissprot:YCHG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCHG_ECOLI hmoment swissprot:YCHG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCHG_ECOLI iep swissprot:YCHG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCHG_ECOLI inforesidue swissprot:YCHG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCHG_ECOLI octanol swissprot:YCHG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCHG_ECOLI pepcoil swissprot:YCHG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCHG_ECOLI pepdigest swissprot:YCHG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCHG_ECOLI pepinfo swissprot:YCHG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCHG_ECOLI pepnet swissprot:YCHG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCHG_ECOLI pepstats swissprot:YCHG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCHG_ECOLI pepwheel swissprot:YCHG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCHG_ECOLI pepwindow swissprot:YCHG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCHG_ECOLI sigcleave swissprot:YCHG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCHG_ECOLI ## Database ID URL or Descriptions # BioGrid 4260723 13 # EcoGene EG12511 ytfK # IntAct P0ADE2 2 # InterPro IPR009491 DUF1107 # Organism YTFK_ECOLI Escherichia coli (strain K12) # PATRIC 32124009 VBIEscCol129921_4349 # Pfam PF06526 DUF1107 # ProDom PD055267 DUF1107 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YTFK_ECOLI Uncharacterized protein YtfK # RefSeq NP_418638 NC_000913.3 # RefSeq WP_000689228 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97113.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # eggNOG ENOG41061GZ Bacteria # eggNOG ENOG4111TN3 LUCA BLAST swissprot:YTFK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YTFK_ECOLI BioCyc ECOL316407:JW5749-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5749-MONOMER BioCyc EcoCyc:G7872-MONOMER http://biocyc.org/getid?id=EcoCyc:G7872-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2404 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2404 EcoGene EG12511 http://www.ecogene.org/geneInfo.php?eg_id=EG12511 EnsemblBacteria AAC77174 http://www.ensemblgenomes.org/id/AAC77174 EnsemblBacteria AAC77174 http://www.ensemblgenomes.org/id/AAC77174 EnsemblBacteria BAE78218 http://www.ensemblgenomes.org/id/BAE78218 EnsemblBacteria BAE78218 http://www.ensemblgenomes.org/id/BAE78218 EnsemblBacteria BAE78218 http://www.ensemblgenomes.org/id/BAE78218 EnsemblBacteria b4217 http://www.ensemblgenomes.org/id/b4217 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 948736 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948736 HOGENOM HOG000276941 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276941&db=HOGENOM6 IntAct P0ADE2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADE2* InterPro IPR009491 http://www.ebi.ac.uk/interpro/entry/IPR009491 KEGG_Gene ecj:JW5749 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5749 KEGG_Gene eco:b4217 http://www.genome.jp/dbget-bin/www_bget?eco:b4217 OMA RHFSVMS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RHFSVMS PSORT swissprot:YTFK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YTFK_ECOLI PSORT-B swissprot:YTFK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YTFK_ECOLI PSORT2 swissprot:YTFK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YTFK_ECOLI Pfam PF06526 http://pfam.xfam.org/family/PF06526 Phobius swissprot:YTFK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YTFK_ECOLI ProteinModelPortal P0ADE2 http://www.proteinmodelportal.org/query/uniprot/P0ADE2 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418638 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418638 RefSeq WP_000689228 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000689228 STRING 511145.b4217 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4217&targetmode=cogs UniProtKB YTFK_ECOLI http://www.uniprot.org/uniprot/YTFK_ECOLI UniProtKB-AC P0ADE2 http://www.uniprot.org/uniprot/P0ADE2 charge swissprot:YTFK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YTFK_ECOLI eggNOG ENOG41061GZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG41061GZ eggNOG ENOG4111TN3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111TN3 epestfind swissprot:YTFK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YTFK_ECOLI garnier swissprot:YTFK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YTFK_ECOLI helixturnhelix swissprot:YTFK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YTFK_ECOLI hmoment swissprot:YTFK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YTFK_ECOLI iep swissprot:YTFK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YTFK_ECOLI inforesidue swissprot:YTFK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YTFK_ECOLI octanol swissprot:YTFK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YTFK_ECOLI pepcoil swissprot:YTFK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YTFK_ECOLI pepdigest swissprot:YTFK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YTFK_ECOLI pepinfo swissprot:YTFK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YTFK_ECOLI pepnet swissprot:YTFK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YTFK_ECOLI pepstats swissprot:YTFK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YTFK_ECOLI pepwheel swissprot:YTFK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YTFK_ECOLI pepwindow swissprot:YTFK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YTFK_ECOLI sigcleave swissprot:YTFK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YTFK_ECOLI ## Database ID URL or Descriptions # BioGrid 4261197 11 # EcoGene EG12308 yfhH # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_function GO:0030246 carbohydrate binding; IEA:InterPro. # GO_process GO:0005975 carbohydrate metabolic process; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # InterPro IPR000281 HTH_RpiR # InterPro IPR001347 SIS # InterPro IPR009057 Homeodomain-like # InterPro IPR011991 WHTH_DNA-bd_dom # Organism YFHH_ECOLI Escherichia coli (strain K12) # PATRIC 32120521 VBIEscCol129921_2663 # PROSITE PS51071 HTH_RPIR # PROSITE PS51464 SIS # Pfam PF01380 SIS # Pfam PF01418 HTH_6 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFHH_ECOLI Uncharacterized HTH-type transcriptional regulator YfhH # RefSeq NP_417056 NC_000913.3 # RefSeq WP_001013779 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA79823.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA10911.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Contains 1 HTH rpiR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00390}. # SIMILARITY Contains 1 SIS domain. {ECO:0000255|PROSITE- ProRule PRU00797}. # SUPFAM SSF46689 SSF46689 # eggNOG COG1737 LUCA # eggNOG ENOG4106G6Q Bacteria BLAST swissprot:YFHH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFHH_ECOLI BioCyc ECOL316407:JW2545-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2545-MONOMER BioCyc EcoCyc:EG12308-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12308-MONOMER DIP DIP-12050N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12050N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1111/j.1365-2958.1992.tb01540.x http://dx.doi.org/10.1111/j.1365-2958.1992.tb01540.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D64044 http://www.ebi.ac.uk/ena/data/view/D64044 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36841 http://www.ebi.ac.uk/ena/data/view/U36841 EMBL X72336 http://www.ebi.ac.uk/ena/data/view/X72336 EchoBASE EB2214 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2214 EcoGene EG12308 http://www.ecogene.org/geneInfo.php?eg_id=EG12308 EnsemblBacteria AAC75614 http://www.ensemblgenomes.org/id/AAC75614 EnsemblBacteria AAC75614 http://www.ensemblgenomes.org/id/AAC75614 EnsemblBacteria BAE76737 http://www.ensemblgenomes.org/id/BAE76737 EnsemblBacteria BAE76737 http://www.ensemblgenomes.org/id/BAE76737 EnsemblBacteria BAE76737 http://www.ensemblgenomes.org/id/BAE76737 EnsemblBacteria b2561 http://www.ensemblgenomes.org/id/b2561 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0030246 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030246 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 947030 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947030 HOGENOM HOG000027157 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000027157&db=HOGENOM6 InParanoid P37767 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37767 InterPro IPR000281 http://www.ebi.ac.uk/interpro/entry/IPR000281 InterPro IPR001347 http://www.ebi.ac.uk/interpro/entry/IPR001347 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW2545 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2545 KEGG_Gene eco:b2561 http://www.genome.jp/dbget-bin/www_bget?eco:b2561 OMA QDLEHAP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QDLEHAP PROSITE PS51071 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51071 PROSITE PS51464 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51464 PSORT swissprot:YFHH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFHH_ECOLI PSORT-B swissprot:YFHH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFHH_ECOLI PSORT2 swissprot:YFHH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFHH_ECOLI Pfam PF01380 http://pfam.xfam.org/family/PF01380 Pfam PF01418 http://pfam.xfam.org/family/PF01418 Phobius swissprot:YFHH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFHH_ECOLI PhylomeDB P37767 http://phylomedb.org/?seqid=P37767 ProteinModelPortal P37767 http://www.proteinmodelportal.org/query/uniprot/P37767 PubMed 1602968 http://www.ncbi.nlm.nih.gov/pubmed/1602968 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417056 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417056 RefSeq WP_001013779 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001013779 SMR P37767 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37767 STRING 511145.b2561 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2561&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 UniProtKB YFHH_ECOLI http://www.uniprot.org/uniprot/YFHH_ECOLI UniProtKB-AC P37767 http://www.uniprot.org/uniprot/P37767 charge swissprot:YFHH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFHH_ECOLI eggNOG COG1737 http://eggnogapi.embl.de/nog_data/html/tree/COG1737 eggNOG ENOG4106G6Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106G6Q epestfind swissprot:YFHH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFHH_ECOLI garnier swissprot:YFHH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFHH_ECOLI helixturnhelix swissprot:YFHH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFHH_ECOLI hmoment swissprot:YFHH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFHH_ECOLI iep swissprot:YFHH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFHH_ECOLI inforesidue swissprot:YFHH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFHH_ECOLI octanol swissprot:YFHH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFHH_ECOLI pepcoil swissprot:YFHH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFHH_ECOLI pepdigest swissprot:YFHH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFHH_ECOLI pepinfo swissprot:YFHH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFHH_ECOLI pepnet swissprot:YFHH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFHH_ECOLI pepstats swissprot:YFHH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFHH_ECOLI pepwheel swissprot:YFHH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFHH_ECOLI pepwindow swissprot:YFHH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFHH_ECOLI sigcleave swissprot:YFHH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFHH_ECOLI ## Database ID URL or Descriptions # BioGrid 4260908 265 # EcoGene EG12367 cusA # FUNCTION CUSA_ECOLI Part of a cation efflux system that mediates resistance to copper and silver. {ECO 0000269|PubMed 11399769, ECO 0000269|PubMed 12813074}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IDA:EcoCyc. # GO_function GO:0005375 copper ion transmembrane transporter activity; IGI:EcoCyc. # GO_function GO:0005507 copper ion binding; IGI:EcoCyc. # GO_function GO:0015080 silver ion transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0006878 cellular copper ion homeostasis; IGI:EcoCyc. # GO_process GO:0010272 response to silver ion; IMP:EcoCyc. # GO_process GO:0010273 detoxification of copper ion; IGI:EcoCyc. # GO_process GO:0015673 silver ion transport; IMP:EcoCyc. # GO_process GO:0015679 plasma membrane copper ion transport; IGI:EcoCyc. # GO_process GO:0046688 response to copper ion; IMP:EcoliWiki. # GO_process GO:0060003 copper ion export; IGI:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # GOslim_process GO:0042592 homeostatic process # GOslim_process GO:0055085 transmembrane transport # Gene3D 3.30.2090.10 -; 2. # INDUCTION Transcriptionally regulated by CusR in response to copper and silver ions. {ECO:0000269|PubMed 11283292}. # IntAct P38054 3 # InterPro IPR001036 Acrflvin-R # InterPro IPR004763 CzcA/CusA/SilA/NccA/HelA/CnrA # InterPro IPR027463 AcrB_DN_DC_subdom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko02020 Two-component system # MISCELLANEOUS CUSA_ECOLI The cus system plays an important role in copper tolerance under anaerobic growth and, under extreme copper stress, in aerobic growth. # Organism CUSA_ECOLI Escherichia coli (strain K12) # PATRIC 32116318 VBIEscCol129921_0599 # PDB 3K07 X-ray; 3.52 A; A=1-1047 # PDB 3K0I X-ray; 4.12 A; A=1-1047 # PDB 3KSO X-ray; 4.37 A; A=1-1047 # PDB 3KSS X-ray; 3.88 A; A=1-1047 # PDB 3NE5 X-ray; 2.90 A; A=2-1047 # PDB 3T51 X-ray; 3.90 A; A=1-1047 # PDB 3T53 X-ray; 3.37 A; A=1-1047 # PDB 3T56 X-ray; 3.42 A; A=1-1047 # PDB 4DNR X-ray; 3.68 A; A=1-1047 # PDB 4DNT X-ray; 3.10 A; A=1-1047 # PDB 4DOP X-ray; 4.20 A; A=1-1047 # PIR E64790 E64790 # PRINTS PR00702 ACRIFLAVINRP # Pfam PF00873 ACR_tran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CUSA_ECOLI Cation efflux system protein CusA # RefSeq NP_415107 NC_000913.3 # RefSeq WP_000573945 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=M58000; Type=Frameshift; Positions=897, 933; Evidence={ECO 0000305}; # SIMILARITY Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. {ECO 0000305}. # SUBCELLULAR LOCATION CUSA_ECOLI Cell inner membrane {ECO 0000305}; Multi- pass membrane protein {ECO 0000305}. # SUBUNIT CUSA_ECOLI The cus efflux system is composed of CusA, CusB, CusC and CusF. # SUPFAM SSF82714 SSF82714; 2 # TCDB 2.A.6.1 the resistance-nodulation-cell division (rnd) superfamily # TIGRFAMs TIGR00914 2A0601 # eggNOG COG3696 LUCA # eggNOG ENOG4108IJF Bacteria BLAST swissprot:CUSA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CUSA_ECOLI BioCyc ECOL316407:JW0564-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0564-MONOMER BioCyc EcoCyc:YBDE-MONOMER http://biocyc.org/getid?id=EcoCyc:YBDE-MONOMER BioCyc MetaCyc:YBDE-MONOMER http://biocyc.org/getid?id=MetaCyc:YBDE-MONOMER COG COG3696 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3696 DIP DIP-9345N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9345N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M104122200 http://dx.doi.org/10.1074/jbc.M104122200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.20.5864-5871.2000 http://dx.doi.org/10.1128/JB.182.20.5864-5871.2000 DOI 10.1128/JB.185.13.3804-3812.2003 http://dx.doi.org/10.1128/JB.185.13.3804-3812.2003 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M58000 http://www.ebi.ac.uk/ena/data/view/M58000 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB2270 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2270 EcoGene EG12367 http://www.ecogene.org/geneInfo.php?eg_id=EG12367 EnsemblBacteria AAC73676 http://www.ensemblgenomes.org/id/AAC73676 EnsemblBacteria AAC73676 http://www.ensemblgenomes.org/id/AAC73676 EnsemblBacteria BAA35215 http://www.ensemblgenomes.org/id/BAA35215 EnsemblBacteria BAA35215 http://www.ensemblgenomes.org/id/BAA35215 EnsemblBacteria BAA35215 http://www.ensemblgenomes.org/id/BAA35215 EnsemblBacteria b0575 http://www.ensemblgenomes.org/id/b0575 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005375 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005375 GO_function GO:0005507 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005507 GO_function GO:0015080 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015080 GO_process GO:0006878 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006878 GO_process GO:0010272 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010272 GO_process GO:0010273 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010273 GO_process GO:0015673 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015673 GO_process GO:0015679 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015679 GO_process GO:0046688 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046688 GO_process GO:0060003 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060003 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 3.30.2090.10 http://www.cathdb.info/version/latest/superfamily/3.30.2090.10 GeneID 945191 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945191 HOGENOM HOG000126202 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126202&db=HOGENOM6 InParanoid P38054 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P38054 IntAct P38054 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P38054* InterPro IPR001036 http://www.ebi.ac.uk/interpro/entry/IPR001036 InterPro IPR004763 http://www.ebi.ac.uk/interpro/entry/IPR004763 InterPro IPR027463 http://www.ebi.ac.uk/interpro/entry/IPR027463 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW0564 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0564 KEGG_Gene eco:b0575 http://www.genome.jp/dbget-bin/www_bget?eco:b0575 KEGG_Orthology KO:K07787 http://www.genome.jp/dbget-bin/www_bget?KO:K07787 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA FLIRIYH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FLIRIYH PDB 3K07 http://www.ebi.ac.uk/pdbe-srv/view/entry/3K07 PDB 3K0I http://www.ebi.ac.uk/pdbe-srv/view/entry/3K0I PDB 3KSO http://www.ebi.ac.uk/pdbe-srv/view/entry/3KSO PDB 3KSS http://www.ebi.ac.uk/pdbe-srv/view/entry/3KSS PDB 3NE5 http://www.ebi.ac.uk/pdbe-srv/view/entry/3NE5 PDB 3T51 http://www.ebi.ac.uk/pdbe-srv/view/entry/3T51 PDB 3T53 http://www.ebi.ac.uk/pdbe-srv/view/entry/3T53 PDB 3T56 http://www.ebi.ac.uk/pdbe-srv/view/entry/3T56 PDB 4DNR http://www.ebi.ac.uk/pdbe-srv/view/entry/4DNR PDB 4DNT http://www.ebi.ac.uk/pdbe-srv/view/entry/4DNT PDB 4DOP http://www.ebi.ac.uk/pdbe-srv/view/entry/4DOP PDBsum 3K07 http://www.ebi.ac.uk/pdbsum/3K07 PDBsum 3K0I http://www.ebi.ac.uk/pdbsum/3K0I PDBsum 3KSO http://www.ebi.ac.uk/pdbsum/3KSO PDBsum 3KSS http://www.ebi.ac.uk/pdbsum/3KSS PDBsum 3NE5 http://www.ebi.ac.uk/pdbsum/3NE5 PDBsum 3T51 http://www.ebi.ac.uk/pdbsum/3T51 PDBsum 3T53 http://www.ebi.ac.uk/pdbsum/3T53 PDBsum 3T56 http://www.ebi.ac.uk/pdbsum/3T56 PDBsum 4DNR http://www.ebi.ac.uk/pdbsum/4DNR PDBsum 4DNT http://www.ebi.ac.uk/pdbsum/4DNT PDBsum 4DOP http://www.ebi.ac.uk/pdbsum/4DOP PRINTS PR00702 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00702 PSORT swissprot:CUSA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CUSA_ECOLI PSORT-B swissprot:CUSA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CUSA_ECOLI PSORT2 swissprot:CUSA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CUSA_ECOLI Pfam PF00873 http://pfam.xfam.org/family/PF00873 Phobius swissprot:CUSA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CUSA_ECOLI PhylomeDB P38054 http://phylomedb.org/?seqid=P38054 ProteinModelPortal P38054 http://www.proteinmodelportal.org/query/uniprot/P38054 PubMed 11004187 http://www.ncbi.nlm.nih.gov/pubmed/11004187 PubMed 11283292 http://www.ncbi.nlm.nih.gov/pubmed/11283292 PubMed 11399769 http://www.ncbi.nlm.nih.gov/pubmed/11399769 PubMed 12813074 http://www.ncbi.nlm.nih.gov/pubmed/12813074 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1711024 http://www.ncbi.nlm.nih.gov/pubmed/1711024 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415107 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415107 RefSeq WP_000573945 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000573945 SMR P38054 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P38054 STRING 511145.b0575 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0575&targetmode=cogs STRING COG3696 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3696&targetmode=cogs SUPFAM SSF82714 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF82714 TCDB 2.A.6.1 http://www.tcdb.org/search/result.php?tc=2.A.6.1 TIGRFAMs TIGR00914 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00914 UniProtKB CUSA_ECOLI http://www.uniprot.org/uniprot/CUSA_ECOLI UniProtKB-AC P38054 http://www.uniprot.org/uniprot/P38054 charge swissprot:CUSA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CUSA_ECOLI eggNOG COG3696 http://eggnogapi.embl.de/nog_data/html/tree/COG3696 eggNOG ENOG4108IJF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108IJF epestfind swissprot:CUSA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CUSA_ECOLI garnier swissprot:CUSA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CUSA_ECOLI helixturnhelix swissprot:CUSA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CUSA_ECOLI hmoment swissprot:CUSA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CUSA_ECOLI iep swissprot:CUSA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CUSA_ECOLI inforesidue swissprot:CUSA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CUSA_ECOLI octanol swissprot:CUSA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CUSA_ECOLI pepcoil swissprot:CUSA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CUSA_ECOLI pepdigest swissprot:CUSA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CUSA_ECOLI pepinfo swissprot:CUSA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CUSA_ECOLI pepnet swissprot:CUSA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CUSA_ECOLI pepstats swissprot:CUSA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CUSA_ECOLI pepwheel swissprot:CUSA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CUSA_ECOLI pepwindow swissprot:CUSA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CUSA_ECOLI sigcleave swissprot:CUSA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CUSA_ECOLI ## Database ID URL or Descriptions # BioGrid 4263335 112 # CDD cd06174 MFS # EcoGene EG13304 dtpD # FUNCTION DTPD_ECOLI Probable proton-dependent permease that transports dipeptides. {ECO 0000250}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IEA:UniProtKB-HAMAP. # GO_component GO:0016021 integral component of membrane; IDA:EcoCyc. # GO_function DTPD_ECOLI GO 0015333 peptide proton symporter activity; IEA UniProtKB-HAMAP. # GO_function GO:0042936 dipeptide transporter activity; IDA:EcoCyc. # GO_process GO:0015031 protein transport; IEA:UniProtKB-KW. # GO_process GO:0042938 dipeptide transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # HAMAP MF_01880 PTR2_DtpD_subfam # IntAct P75742 2 # InterPro IPR000109 POT_fam # InterPro IPR005279 Dipep/tripep_permease # InterPro IPR018456 PTR2_symporter_CS # InterPro IPR020846 MFS_dom # InterPro IPR023777 AA/pep_transptr_DtpD # Organism DTPD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11654 PTHR11654; 2 # PATRIC 32116613 VBIEscCol129921_0739 # PDB 4Q65 X-ray; 3.40 A; A=1-493 # PIR D64806 D64806 # PROSITE PS01022 PTR2_1 # PROSITE PS01023 PTR2_2 # PROSITE PS50850 MFS # Pfam PF00854 PTR2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DTPD_ECOLI Dipeptide permease D # RefSeq NP_415237 NC_000913.3 # RefSeq WP_001032689 NZ_LN832404.1 # SIMILARITY Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpD subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION DTPD_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF103473 SSF103473; 2 # TCDB 2.A.17.1 the proton-dependent oligopeptide transporter (pot/ptr) family # TIGRFAMs TIGR00924 yjdL_sub1_fam # eggNOG COG3104 LUCA # eggNOG ENOG4105DUX Bacteria BLAST swissprot:DTPD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DTPD_ECOLI BioCyc ECOL316407:JW0699-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0699-MONOMER BioCyc EcoCyc:B0709-MONOMER http://biocyc.org/getid?id=EcoCyc:B0709-MONOMER BioCyc MetaCyc:B0709-MONOMER http://biocyc.org/getid?id=MetaCyc:B0709-MONOMER COG COG3104 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3104 DIP DIP-11394N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11394N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3088 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3088 EcoGene EG13304 http://www.ecogene.org/geneInfo.php?eg_id=EG13304 EnsemblBacteria AAC73803 http://www.ensemblgenomes.org/id/AAC73803 EnsemblBacteria AAC73803 http://www.ensemblgenomes.org/id/AAC73803 EnsemblBacteria BAA35368 http://www.ensemblgenomes.org/id/BAA35368 EnsemblBacteria BAA35368 http://www.ensemblgenomes.org/id/BAA35368 EnsemblBacteria BAA35368 http://www.ensemblgenomes.org/id/BAA35368 EnsemblBacteria b0709 http://www.ensemblgenomes.org/id/b0709 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015333 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015333 GO_function GO:0042936 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042936 GO_process GO:0015031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031 GO_process GO:0042938 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042938 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 947368 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947368 HAMAP MF_01880 http://hamap.expasy.org/unirule/MF_01880 HOGENOM HOG000243450 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000243450&db=HOGENOM6 InParanoid P75742 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75742 IntAct P75742 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75742* InterPro IPR000109 http://www.ebi.ac.uk/interpro/entry/IPR000109 InterPro IPR005279 http://www.ebi.ac.uk/interpro/entry/IPR005279 InterPro IPR018456 http://www.ebi.ac.uk/interpro/entry/IPR018456 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 InterPro IPR023777 http://www.ebi.ac.uk/interpro/entry/IPR023777 KEGG_Gene ecj:JW0699 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0699 KEGG_Gene eco:b0709 http://www.genome.jp/dbget-bin/www_bget?eco:b0709 KEGG_Orthology KO:K03305 http://www.genome.jp/dbget-bin/www_bget?KO:K03305 MINT MINT-1290177 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1290177 OMA AWLIKES http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AWLIKES PANTHER PTHR11654 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11654 PDB 4Q65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4Q65 PDBsum 4Q65 http://www.ebi.ac.uk/pdbsum/4Q65 PROSITE PS01022 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01022 PROSITE PS01023 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01023 PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:DTPD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DTPD_ECOLI PSORT-B swissprot:DTPD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DTPD_ECOLI PSORT2 swissprot:DTPD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DTPD_ECOLI Pfam PF00854 http://pfam.xfam.org/family/PF00854 Phobius swissprot:DTPD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DTPD_ECOLI PhylomeDB P75742 http://phylomedb.org/?seqid=P75742 ProteinModelPortal P75742 http://www.proteinmodelportal.org/query/uniprot/P75742 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415237 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415237 RefSeq WP_001032689 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001032689 SMR P75742 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75742 STRING 511145.b0709 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0709&targetmode=cogs STRING COG3104 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3104&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.17.1 http://www.tcdb.org/search/result.php?tc=2.A.17.1 TIGRFAMs TIGR00924 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00924 UniProtKB DTPD_ECOLI http://www.uniprot.org/uniprot/DTPD_ECOLI UniProtKB-AC P75742 http://www.uniprot.org/uniprot/P75742 charge swissprot:DTPD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DTPD_ECOLI eggNOG COG3104 http://eggnogapi.embl.de/nog_data/html/tree/COG3104 eggNOG ENOG4105DUX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DUX epestfind swissprot:DTPD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DTPD_ECOLI garnier swissprot:DTPD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DTPD_ECOLI helixturnhelix swissprot:DTPD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DTPD_ECOLI hmoment swissprot:DTPD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DTPD_ECOLI iep swissprot:DTPD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DTPD_ECOLI inforesidue swissprot:DTPD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DTPD_ECOLI octanol swissprot:DTPD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DTPD_ECOLI pepcoil swissprot:DTPD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DTPD_ECOLI pepdigest swissprot:DTPD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DTPD_ECOLI pepinfo swissprot:DTPD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DTPD_ECOLI pepnet swissprot:DTPD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DTPD_ECOLI pepstats swissprot:DTPD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DTPD_ECOLI pepwheel swissprot:DTPD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DTPD_ECOLI pepwindow swissprot:DTPD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DTPD_ECOLI sigcleave swissprot:DTPD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DTPD_ECOLI ## Database ID URL or Descriptions # BioGrid 4262406 11 # EcoGene EG12733 ygjV # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR019629 Uncharacterised_HI1736/YgjV # InterPro IPR026267 YgjV # Organism YGJV_ECOLI Escherichia coli (strain K12) # PATRIC 32121598 VBIEscCol129921_3185 # PIR G65097 G65097 # PIRSF PIRSF011443 YgjV # Pfam PF10688 Imp-YgjV # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGJV_ECOLI Inner membrane protein YgjV # RefSeq NP_417561 NC_000913.3 # RefSeq WP_000128135 NZ_LN832404.1 # SUBCELLULAR LOCATION YGJV_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG ENOG4105P66 Bacteria # eggNOG ENOG410XT5W LUCA BLAST swissprot:YGJV_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGJV_ECOLI BioCyc ECOL316407:JW3061-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3061-MONOMER BioCyc EcoCyc:G7608-MONOMER http://biocyc.org/getid?id=EcoCyc:G7608-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.052018199 http://dx.doi.org/10.1073/pnas.052018199 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D13328 http://www.ebi.ac.uk/ena/data/view/D13328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2591 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2591 EcoGene EG12733 http://www.ecogene.org/geneInfo.php?eg_id=EG12733 EnsemblBacteria AAC76125 http://www.ensemblgenomes.org/id/AAC76125 EnsemblBacteria AAC76125 http://www.ensemblgenomes.org/id/AAC76125 EnsemblBacteria BAE77140 http://www.ensemblgenomes.org/id/BAE77140 EnsemblBacteria BAE77140 http://www.ensemblgenomes.org/id/BAE77140 EnsemblBacteria BAE77140 http://www.ensemblgenomes.org/id/BAE77140 EnsemblBacteria b3090 http://www.ensemblgenomes.org/id/b3090 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 947604 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947604 HOGENOM HOG000125147 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125147&db=HOGENOM6 InterPro IPR019629 http://www.ebi.ac.uk/interpro/entry/IPR019629 InterPro IPR026267 http://www.ebi.ac.uk/interpro/entry/IPR026267 KEGG_Gene ecj:JW3061 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3061 KEGG_Gene eco:b3090 http://www.genome.jp/dbget-bin/www_bget?eco:b3090 OMA LFNSFCW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LFNSFCW PSORT swissprot:YGJV_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGJV_ECOLI PSORT-B swissprot:YGJV_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGJV_ECOLI PSORT2 swissprot:YGJV_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGJV_ECOLI Pfam PF10688 http://pfam.xfam.org/family/PF10688 Phobius swissprot:YGJV_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGJV_ECOLI ProteinModelPortal P42603 http://www.proteinmodelportal.org/query/uniprot/P42603 PubMed 11867724 http://www.ncbi.nlm.nih.gov/pubmed/11867724 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417561 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417561 RefSeq WP_000128135 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000128135 STRING 511145.b3090 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3090&targetmode=cogs UniProtKB YGJV_ECOLI http://www.uniprot.org/uniprot/YGJV_ECOLI UniProtKB-AC P42603 http://www.uniprot.org/uniprot/P42603 charge swissprot:YGJV_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGJV_ECOLI eggNOG ENOG4105P66 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105P66 eggNOG ENOG410XT5W http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XT5W epestfind swissprot:YGJV_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGJV_ECOLI garnier swissprot:YGJV_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGJV_ECOLI helixturnhelix swissprot:YGJV_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGJV_ECOLI hmoment swissprot:YGJV_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGJV_ECOLI iep swissprot:YGJV_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGJV_ECOLI inforesidue swissprot:YGJV_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGJV_ECOLI octanol swissprot:YGJV_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGJV_ECOLI pepcoil swissprot:YGJV_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGJV_ECOLI pepdigest swissprot:YGJV_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGJV_ECOLI pepinfo swissprot:YGJV_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGJV_ECOLI pepnet swissprot:YGJV_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGJV_ECOLI pepstats swissprot:YGJV_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGJV_ECOLI pepwheel swissprot:YGJV_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGJV_ECOLI pepwindow swissprot:YGJV_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGJV_ECOLI sigcleave swissprot:YGJV_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGJV_ECOLI ## Database ID URL or Descriptions # BioGrid 4261640 150 # DISRUPTION PHENOTYPE Mutants have no detectable phenotype under standard laboratory conditions. They are more resistant to trimethoprim than wild-type cells. {ECO:0000269|PubMed 24659771}. # EcoGene EG11084 mraZ # FUNCTION MRAZ_ECOLI Negatively regulates its own expression and that of the subsequent genes in the proximal part of the division and cell wall (dcw) gene cluster. Acts by binding directly to DNA. May also regulate the expression of genes outside the dcw cluster. {ECO 0000255|HAMAP-Rule MF_01008, ECO 0000269|PubMed 24659771}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-HAMAP. # GO_component GO:0009295 nucleoid; IEA:UniProtKB-SubCell. # GO_function GO:0000976 transcription regulatory region sequence-specific DNA binding; IDA:EcoCyc. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IDA:EcoCyc. # GO_function GO:0043565 sequence-specific DNA binding; ISM:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IEP:EcoCyc. # GO_process GO:2000143 negative regulation of DNA-templated transcription, initiation; IEP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # HAMAP MF_01008 MraZ # INDUCTION Negatively autoregulated. {ECO:0000269|PubMed 24659771}. # IntAct P22186 5 # InterPro IPR003444 MraZ # InterPro IPR007159 SpoVT-AbrB_dom # InterPro IPR020603 MraZ_dom # MISCELLANEOUS Overproduction is lethal and perturbs cell division. It destabilizes the divisome, but does not affect FtsZ levels or prevent Z ring assembly. Co-overproduction of RsmH (MraW) protects the cell from the toxic effects of MraZ overproduction (PubMed:24659771). {ECO 0000305|PubMed:24659771}. # Organism MRAZ_ECOLI Escherichia coli (strain K12) # PATRIC 32115267 VBIEscCol129921_0085 # PIR S14388 S14388 # PROSITE PS51740 SPOVT_ABRB; 2 # Pfam PF02381 MraZ; 2 # ProDom PD006745 MraZ # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MRAZ_ECOLI Transcriptional regulator MraZ # RefSeq NP_414623 NC_000913.3 # RefSeq WP_001295533 NZ_LN832404.1 # SIMILARITY Belongs to the MraZ family. {ECO:0000255|HAMAP- Rule MF_01008}. # SIMILARITY Contains 2 SpoVT-AbrB domains. {ECO:0000255|PROSITE- ProRule PRU01076}. # SUBCELLULAR LOCATION MRAZ_ECOLI Cytoplasm, nucleoid {ECO 0000255|HAMAP- Rule MF_01008, ECO 0000269|PubMed 24659771}. # SUBUNIT Dodecamer. {ECO:0000269|PubMed 16511046}. # TIGRFAMs TIGR00242 TIGR00242 # eggNOG COG2001 LUCA # eggNOG ENOG4108V6E Bacteria BLAST swissprot:MRAZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MRAZ_ECOLI BioCyc ECOL316407:JW0079-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0079-MONOMER BioCyc EcoCyc:EG11084-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11084-MONOMER COG COG2001 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2001 DIP DIP-11166N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11166N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/18.9.2813 http://dx.doi.org/10.1093/nar/18.9.2813 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1107/S1744309105007657 http://dx.doi.org/10.1107/S1744309105007657 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01370-13 http://dx.doi.org/10.1128/JB.01370-13 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X52063 http://www.ebi.ac.uk/ena/data/view/X52063 EMBL X55034 http://www.ebi.ac.uk/ena/data/view/X55034 EchoBASE EB1076 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1076 EcoGene EG11084 http://www.ecogene.org/geneInfo.php?eg_id=EG11084 EnsemblBacteria AAC73192 http://www.ensemblgenomes.org/id/AAC73192 EnsemblBacteria AAC73192 http://www.ensemblgenomes.org/id/AAC73192 EnsemblBacteria BAB96649 http://www.ensemblgenomes.org/id/BAB96649 EnsemblBacteria BAB96649 http://www.ensemblgenomes.org/id/BAB96649 EnsemblBacteria BAB96649 http://www.ensemblgenomes.org/id/BAB96649 EnsemblBacteria b0081 http://www.ensemblgenomes.org/id/b0081 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0009295 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009295 GO_function GO:0000976 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000976 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GO_process GO:2000143 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000143 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 944810 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944810 HAMAP MF_01008 http://hamap.expasy.org/unirule/MF_01008 HOGENOM HOG000283907 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000283907&db=HOGENOM6 InParanoid P22186 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P22186 IntAct P22186 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P22186* InterPro IPR003444 http://www.ebi.ac.uk/interpro/entry/IPR003444 InterPro IPR007159 http://www.ebi.ac.uk/interpro/entry/IPR007159 InterPro IPR020603 http://www.ebi.ac.uk/interpro/entry/IPR020603 KEGG_Gene ecj:JW0079 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0079 KEGG_Gene eco:b0081 http://www.genome.jp/dbget-bin/www_bget?eco:b0081 KEGG_Orthology KO:K03925 http://www.genome.jp/dbget-bin/www_bget?KO:K03925 OMA CELDGNG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CELDGNG PROSITE PS51740 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51740 PSORT swissprot:MRAZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MRAZ_ECOLI PSORT-B swissprot:MRAZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MRAZ_ECOLI PSORT2 swissprot:MRAZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MRAZ_ECOLI Pfam PF02381 http://pfam.xfam.org/family/PF02381 Phobius swissprot:MRAZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MRAZ_ECOLI PhylomeDB P22186 http://phylomedb.org/?seqid=P22186 ProteinModelPortal P22186 http://www.proteinmodelportal.org/query/uniprot/P22186 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16511046 http://www.ncbi.nlm.nih.gov/pubmed/16511046 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2187182 http://www.ncbi.nlm.nih.gov/pubmed/2187182 PubMed 24659771 http://www.ncbi.nlm.nih.gov/pubmed/24659771 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414623 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414623 RefSeq WP_001295533 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295533 SMR P22186 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P22186 STRING 511145.b0081 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0081&targetmode=cogs STRING COG2001 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2001&targetmode=cogs TIGRFAMs TIGR00242 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00242 UniProtKB MRAZ_ECOLI http://www.uniprot.org/uniprot/MRAZ_ECOLI UniProtKB-AC P22186 http://www.uniprot.org/uniprot/P22186 charge swissprot:MRAZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MRAZ_ECOLI eggNOG COG2001 http://eggnogapi.embl.de/nog_data/html/tree/COG2001 eggNOG ENOG4108V6E http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108V6E epestfind swissprot:MRAZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MRAZ_ECOLI garnier swissprot:MRAZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MRAZ_ECOLI helixturnhelix swissprot:MRAZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MRAZ_ECOLI hmoment swissprot:MRAZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MRAZ_ECOLI iep swissprot:MRAZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MRAZ_ECOLI inforesidue swissprot:MRAZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MRAZ_ECOLI octanol swissprot:MRAZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MRAZ_ECOLI pepcoil swissprot:MRAZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MRAZ_ECOLI pepdigest swissprot:MRAZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MRAZ_ECOLI pepinfo swissprot:MRAZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MRAZ_ECOLI pepnet swissprot:MRAZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MRAZ_ECOLI pepstats swissprot:MRAZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MRAZ_ECOLI pepwheel swissprot:MRAZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MRAZ_ECOLI pepwindow swissprot:MRAZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MRAZ_ECOLI sigcleave swissprot:MRAZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MRAZ_ECOLI ## Database ID URL or Descriptions # BioGrid 4260946 399 # EcoGene EG13221 rof # FUNCTION ROF_ECOLI Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination. # GO_process GO:0031554 regulation of DNA-templated transcription, termination; IMP:EcoCyc. # GO_process GO:0060567 negative regulation of DNA-templated transcription, termination; IDA:EcoCyc. # GOslim_process GO:0008150 biological_process # INTERACTION ROF_ECOLI P0AG30 rho; NbExp=2; IntAct=EBI-1114609, EBI-545468; # IntAct P0AFW8 11 # InterPro IPR009778 ROF # InterPro IPR023534 Rof/RNase_P-like # Organism ROF_ECOLI Escherichia coli (strain K12) # PATRIC 32115489 VBIEscCol129921_0196 # PDB 1SG5 NMR; -; A=1-84 # Pfam PF07073 ROF # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ROF_ECOLI Protein rof # RefSeq NP_414731 NC_000913.3 # SEQUENCE CAUTION Sequence=CAA90752.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SUPFAM SSF101744 SSF101744 # eggNOG COG4568 LUCA # eggNOG ENOG4105M1T Bacteria BLAST swissprot:ROF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ROF_ECOLI BioCyc ECOL316407:JW0184-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0184-MONOMER BioCyc EcoCyc:G6097-MONOMER http://biocyc.org/getid?id=EcoCyc:G6097-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1998.00981.x http://dx.doi.org/10.1046/j.1365-2958.1998.00981.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D49445 http://www.ebi.ac.uk/ena/data/view/D49445 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL Z50870 http://www.ebi.ac.uk/ena/data/view/Z50870 EchoBASE EB3012 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3012 EcoGene EG13221 http://www.ecogene.org/geneInfo.php?eg_id=EG13221 EnsemblBacteria AAC73300 http://www.ensemblgenomes.org/id/AAC73300 EnsemblBacteria AAC73300 http://www.ensemblgenomes.org/id/AAC73300 EnsemblBacteria BAA77864 http://www.ensemblgenomes.org/id/BAA77864 EnsemblBacteria BAA77864 http://www.ensemblgenomes.org/id/BAA77864 EnsemblBacteria BAA77864 http://www.ensemblgenomes.org/id/BAA77864 EnsemblBacteria b0189 http://www.ensemblgenomes.org/id/b0189 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0031554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031554 GO_process GO:0060567 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060567 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 944891 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944891 HOGENOM HOG000001314 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000001314&db=HOGENOM6 IntAct P0AFW8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFW8* InterPro IPR009778 http://www.ebi.ac.uk/interpro/entry/IPR009778 InterPro IPR023534 http://www.ebi.ac.uk/interpro/entry/IPR023534 KEGG_Gene ecj:JW0184 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0184 KEGG_Gene eco:b0189 http://www.genome.jp/dbget-bin/www_bget?eco:b0189 MINT MINT-8200743 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8200743 OMA GGKEEYL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GGKEEYL PDB 1SG5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1SG5 PDBsum 1SG5 http://www.ebi.ac.uk/pdbsum/1SG5 PSORT swissprot:ROF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ROF_ECOLI PSORT-B swissprot:ROF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ROF_ECOLI PSORT2 swissprot:ROF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ROF_ECOLI Pfam PF07073 http://pfam.xfam.org/family/PF07073 Phobius swissprot:ROF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ROF_ECOLI ProteinModelPortal P0AFW8 http://www.proteinmodelportal.org/query/uniprot/P0AFW8 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9723924 http://www.ncbi.nlm.nih.gov/pubmed/9723924 RefSeq NP_414731 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414731 SMR P0AFW8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFW8 STRING 511145.b0189 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0189&targetmode=cogs SUPFAM SSF101744 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF101744 UniProtKB ROF_ECOLI http://www.uniprot.org/uniprot/ROF_ECOLI UniProtKB-AC P0AFW8 http://www.uniprot.org/uniprot/P0AFW8 charge swissprot:ROF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ROF_ECOLI eggNOG COG4568 http://eggnogapi.embl.de/nog_data/html/tree/COG4568 eggNOG ENOG4105M1T http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105M1T epestfind swissprot:ROF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ROF_ECOLI garnier swissprot:ROF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ROF_ECOLI helixturnhelix swissprot:ROF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ROF_ECOLI hmoment swissprot:ROF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ROF_ECOLI iep swissprot:ROF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ROF_ECOLI inforesidue swissprot:ROF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ROF_ECOLI octanol swissprot:ROF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ROF_ECOLI pepcoil swissprot:ROF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ROF_ECOLI pepdigest swissprot:ROF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ROF_ECOLI pepinfo swissprot:ROF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ROF_ECOLI pepnet swissprot:ROF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ROF_ECOLI pepstats swissprot:ROF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ROF_ECOLI pepwheel swissprot:ROF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ROF_ECOLI pepwindow swissprot:ROF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ROF_ECOLI sigcleave swissprot:ROF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ROF_ECOLI ## Database ID URL or Descriptions # AltName TTDT_ECOLI Tartrate carrier # AltName TTDT_ECOLI Tartrate transporter # BIOPHYSICOCHEMICAL PROPERTIES TTDT_ECOLI Kinetic parameters KM=700 uM for tartrate {ECO 0000269|PubMed 17172328}; KM=400 uM for succinate {ECO 0000269|PubMed 17172328}; Vmax=110 umol/min/g enzyme for tartrate import {ECO 0000269|PubMed 17172328}; Vmax=16 umol/min/g enzyme for succinate export {ECO 0000269|PubMed 17172328}; # BioGrid 4262386 10 # EcoGene EG12393 ttdT # FUNCTION TTDT_ECOLI Catalyzes the uptake of tartrate in exchange for intracellular succinate. Essential for anaerobic L-tartrate fermentation. {ECO 0000269|PubMed 17172328}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IBA:GO_Central. # GO_function GO:0015297 antiporter activity; IMP:EcoliWiki. # GO_process GO:0006814 sodium ion transport; IEA:InterPro. # GO_process GO:0098656 anion transmembrane transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # INDUCTION Induced by tartrate, via TtdR. {ECO:0000269|PubMed 16804186}. # InterPro IPR001898 Na/sul_symport # InterPro IPR030676 CitT-rel # KEGG_Brite ko02000 Transporters # Organism TTDT_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10283:SF13 PTHR10283:SF13; 2 # PATRIC 32121540 VBIEscCol129921_3157 # PIR E65094 QQECRS # PIRSF PIRSF002457 DASS # Pfam PF00939 Na_sulph_symp # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TTDT_ECOLI L-tartrate/succinate antiporter # RefSeq NP_417535 NC_000913.3 # RefSeq WP_000804973 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=M16194; Type=Frameshift; Positions=35, 51, 132, 245, 268, 443; Evidence={ECO 0000305}; # SIMILARITY Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. DIT1 subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION TTDT_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.47.3:the divalent anion na(+) symporter (dass) family # TIGRFAMs TIGR00785 dass # eggNOG COG0471 LUCA # eggNOG ENOG4107QPK Bacteria BLAST swissprot:TTDT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TTDT_ECOLI BioCyc ECOL316407:JW3035-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3035-MONOMER BioCyc EcoCyc:YGJE-MONOMER http://biocyc.org/getid?id=EcoCyc:YGJE-MONOMER BioCyc MetaCyc:YGJE-MONOMER http://biocyc.org/getid?id=MetaCyc:YGJE-MONOMER COG COG0471 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0471 DOI 10.1016/0378-1119(87)90303-9 http://dx.doi.org/10.1016/0378-1119(87)90303-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1099/mic.0.28753-0 http://dx.doi.org/10.1099/mic.0.28753-0 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01402-06 http://dx.doi.org/10.1128/JB.01402-06 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M16194 http://www.ebi.ac.uk/ena/data/view/M16194 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28379 http://www.ebi.ac.uk/ena/data/view/U28379 EchoBASE EB2294 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2294 EcoGene EG12393 http://www.ecogene.org/geneInfo.php?eg_id=EG12393 EnsemblBacteria AAC76099 http://www.ensemblgenomes.org/id/AAC76099 EnsemblBacteria AAC76099 http://www.ensemblgenomes.org/id/AAC76099 EnsemblBacteria BAE77114 http://www.ensemblgenomes.org/id/BAE77114 EnsemblBacteria BAE77114 http://www.ensemblgenomes.org/id/BAE77114 EnsemblBacteria BAE77114 http://www.ensemblgenomes.org/id/BAE77114 EnsemblBacteria b3063 http://www.ensemblgenomes.org/id/b3063 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015297 GO_process GO:0006814 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814 GO_process GO:0098656 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098656 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 947576 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947576 HOGENOM HOG000117911 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117911&db=HOGENOM6 InParanoid P39414 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39414 InterPro IPR001898 http://www.ebi.ac.uk/interpro/entry/IPR001898 InterPro IPR030676 http://www.ebi.ac.uk/interpro/entry/IPR030676 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3035 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3035 KEGG_Gene eco:b3063 http://www.genome.jp/dbget-bin/www_bget?eco:b3063 KEGG_Orthology KO:K11106 http://www.genome.jp/dbget-bin/www_bget?KO:K11106 OMA NAWLYFC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NAWLYFC PANTHER PTHR10283:SF13 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10283:SF13 PSORT swissprot:TTDT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TTDT_ECOLI PSORT-B swissprot:TTDT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TTDT_ECOLI PSORT2 swissprot:TTDT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TTDT_ECOLI Pfam PF00939 http://pfam.xfam.org/family/PF00939 Phobius swissprot:TTDT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TTDT_ECOLI PhylomeDB P39414 http://phylomedb.org/?seqid=P39414 ProteinModelPortal P39414 http://www.proteinmodelportal.org/query/uniprot/P39414 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16804186 http://www.ncbi.nlm.nih.gov/pubmed/16804186 PubMed 17172328 http://www.ncbi.nlm.nih.gov/pubmed/17172328 PubMed 3297921 http://www.ncbi.nlm.nih.gov/pubmed/3297921 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9696764 http://www.ncbi.nlm.nih.gov/pubmed/9696764 RefSeq NP_417535 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417535 RefSeq WP_000804973 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000804973 STRING 511145.b3063 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3063&targetmode=cogs STRING COG0471 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0471&targetmode=cogs TCDB 2.A.47.3 http://www.tcdb.org/search/result.php?tc=2.A.47.3 TIGRFAMs TIGR00785 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00785 UniProtKB TTDT_ECOLI http://www.uniprot.org/uniprot/TTDT_ECOLI UniProtKB-AC P39414 http://www.uniprot.org/uniprot/P39414 charge swissprot:TTDT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TTDT_ECOLI eggNOG COG0471 http://eggnogapi.embl.de/nog_data/html/tree/COG0471 eggNOG ENOG4107QPK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QPK epestfind swissprot:TTDT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TTDT_ECOLI garnier swissprot:TTDT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TTDT_ECOLI helixturnhelix swissprot:TTDT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TTDT_ECOLI hmoment swissprot:TTDT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TTDT_ECOLI iep swissprot:TTDT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TTDT_ECOLI inforesidue swissprot:TTDT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TTDT_ECOLI octanol swissprot:TTDT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TTDT_ECOLI pepcoil swissprot:TTDT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TTDT_ECOLI pepdigest swissprot:TTDT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TTDT_ECOLI pepinfo swissprot:TTDT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TTDT_ECOLI pepnet swissprot:TTDT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TTDT_ECOLI pepstats swissprot:TTDT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TTDT_ECOLI pepwheel swissprot:TTDT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TTDT_ECOLI pepwindow swissprot:TTDT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TTDT_ECOLI sigcleave swissprot:TTDT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TTDT_ECOLI ## Database ID URL or Descriptions # BioGrid 4259653 213 # EcoGene EG10984 sulA # FUNCTION SULA_ECOLI Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. The effect of overexpression of SulA is neutralized by antitoxin CbeA (yeeU) (PubMed 22515815). {ECO 0000269|PubMed 10931335, ECO 0000269|PubMed 18245292, ECO 0000269|PubMed 2145263, ECO 0000269|PubMed 22515815, ECO 0000269|PubMed 6087326, ECO 0000269|PubMed 8432706, ECO 0000269|PubMed 9501185}. # GO_process GO:0006281 DNA repair; IEA:UniProtKB-KW. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0007049 cell cycle; IEA:UniProtKB-KW. # GO_process GO:0009432 SOS response; IEA:UniProtKB-HAMAP. # GO_process GO:0032466 negative regulation of cytokinesis; IMP:CACAO. # GO_process GO:0051301 cell division; IEA:UniProtKB-KW. # GO_process GO:0051782 negative regulation of cell division; IMP:EcoliWiki. # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0007049 cell cycle # GOslim_process GO:0008150 biological_process # GOslim_process GO:0051301 cell division # Gene3D 3.40.50.300 -; 1. # HAMAP MF_01179 SulA # INDUCTION SULA_ECOLI By DNA damage, as part of the SOS response, repressed by LexA (PubMed 3297925). Induced 8-fold by hydroxyurea (at protein level) (PubMed 20005847). {ECO 0000269|PubMed 20005847, ECO 0000269|PubMed 3297925}. # INTERACTION SULA_ECOLI P0A6H5 hslU; NbExp=5; IntAct=EBI-2012039, EBI-369317; # IntAct P0AFZ5 2 # InterPro IPR004596 Cell_div_suppressor_SulA # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko03036 Chromosome # Organism SULA_ECOLI Escherichia coli (strain K12) # PATRIC 32117135 VBIEscCol129921_0992 # PIR A29016 QQECA1 # PIRSF PIRSF003093 SulA # PTM SULA_ECOLI Is rapidly cleaved and degraded by the Lon protease once DNA damage is repaired. {ECO 0000269|PubMed 10788793, ECO 0000269|PubMed 11513747, ECO 0000269|PubMed 6300834, ECO 0000269|PubMed 9180687}. # Pfam PF03846 SulA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SULA_ECOLI Cell division inhibitor SulA # RefSeq NP_415478 NC_000913.3 # RefSeq WP_000288710 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA23587.1; Type=Frameshift; Positions=145; Evidence={ECO 0000305}; # SIMILARITY Belongs to the SulA family. {ECO 0000305}. # SUBUNIT SULA_ECOLI Interacts with FtsZ. {ECO 0000269|PubMed 2994059, ECO 0000269|PubMed 7726836}. # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR00623 sula # eggNOG COG5404 LUCA # eggNOG ENOG4108ZD2 Bacteria BLAST swissprot:SULA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SULA_ECOLI BioCyc ECOL316407:JW0941-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0941-MONOMER BioCyc EcoCyc:EG10984-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10984-MONOMER COG COG5404 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG5404 DIP DIP-10945N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10945N DOI 10.1006/bbrc.1995.1489 http://dx.doi.org/10.1006/bbrc.1995.1489 DOI 10.1007/BF00325901 http://dx.doi.org/10.1007/BF00325901 DOI 10.1007/s004380050426 http://dx.doi.org/10.1007/s004380050426 DOI 10.1016/0378-1119(87)90392-1 http://dx.doi.org/10.1016/0378-1119(87)90392-1 DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/0264-6021:3580473 http://dx.doi.org/10.1042/0264-6021:3580473 DOI 10.1046/j.1365-2958.2000.02007.x http://dx.doi.org/10.1046/j.1365-2958.2000.02007.x DOI 10.1073/pnas.80.2.358 http://dx.doi.org/10.1073/pnas.80.2.358 DOI 10.1073/pnas.81.14.4490 http://dx.doi.org/10.1073/pnas.81.14.4490 DOI 10.1073/pnas.82.18.6045 http://dx.doi.org/10.1073/pnas.82.18.6045 DOI 10.1073/pnas.95.6.2885 http://dx.doi.org/10.1073/pnas.95.6.2885 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/8.13.3011 http://dx.doi.org/10.1093/nar/8.13.3011 DOI 10.1093/oxfordjournals.jbchem.a022677 http://dx.doi.org/10.1093/oxfordjournals.jbchem.a022677 DOI 10.1111/j.1365-2958.2012.08068.x http://dx.doi.org/10.1111/j.1365-2958.2012.08068.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01612-07 http://dx.doi.org/10.1128/JB.01612-07 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00307 http://www.ebi.ac.uk/ena/data/view/V00307 EMBL V00358 http://www.ebi.ac.uk/ena/data/view/V00358 EchoBASE EB0977 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0977 EcoGene EG10984 http://www.ecogene.org/geneInfo.php?eg_id=EG10984 EnsemblBacteria AAC74044 http://www.ensemblgenomes.org/id/AAC74044 EnsemblBacteria AAC74044 http://www.ensemblgenomes.org/id/AAC74044 EnsemblBacteria BAA35716 http://www.ensemblgenomes.org/id/BAA35716 EnsemblBacteria BAA35716 http://www.ensemblgenomes.org/id/BAA35716 EnsemblBacteria BAA35716 http://www.ensemblgenomes.org/id/BAA35716 EnsemblBacteria b0958 http://www.ensemblgenomes.org/id/b0958 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006281 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GO_process GO:0009432 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009432 GO_process GO:0032466 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032466 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GO_process GO:0051782 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051782 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947335 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947335 HAMAP MF_01179 http://hamap.expasy.org/unirule/MF_01179 HOGENOM HOG000290470 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000290470&db=HOGENOM6 IntAct P0AFZ5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFZ5* InterPro IPR004596 http://www.ebi.ac.uk/interpro/entry/IPR004596 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene ecj:JW0941 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0941 KEGG_Gene eco:b0958 http://www.genome.jp/dbget-bin/www_bget?eco:b0958 KEGG_Orthology KO:K13053 http://www.genome.jp/dbget-bin/www_bget?KO:K13053 OMA YGFIMRP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YGFIMRP PSORT swissprot:SULA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SULA_ECOLI PSORT-B swissprot:SULA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SULA_ECOLI PSORT2 swissprot:SULA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SULA_ECOLI Pfam PF03846 http://pfam.xfam.org/family/PF03846 Phobius swissprot:SULA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SULA_ECOLI ProteinModelPortal P0AFZ5 http://www.proteinmodelportal.org/query/uniprot/P0AFZ5 PubMed 10788793 http://www.ncbi.nlm.nih.gov/pubmed/10788793 PubMed 10931335 http://www.ncbi.nlm.nih.gov/pubmed/10931335 PubMed 11513747 http://www.ncbi.nlm.nih.gov/pubmed/11513747 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18245292 http://www.ncbi.nlm.nih.gov/pubmed/18245292 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 2145263 http://www.ncbi.nlm.nih.gov/pubmed/2145263 PubMed 22515815 http://www.ncbi.nlm.nih.gov/pubmed/22515815 PubMed 2994059 http://www.ncbi.nlm.nih.gov/pubmed/2994059 PubMed 3297925 http://www.ncbi.nlm.nih.gov/pubmed/3297925 PubMed 6087326 http://www.ncbi.nlm.nih.gov/pubmed/6087326 PubMed 6253901 http://www.ncbi.nlm.nih.gov/pubmed/6253901 PubMed 6300834 http://www.ncbi.nlm.nih.gov/pubmed/6300834 PubMed 6306396 http://www.ncbi.nlm.nih.gov/pubmed/6306396 PubMed 7726836 http://www.ncbi.nlm.nih.gov/pubmed/7726836 PubMed 8432706 http://www.ncbi.nlm.nih.gov/pubmed/8432706 PubMed 8752322 http://www.ncbi.nlm.nih.gov/pubmed/8752322 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9180687 http://www.ncbi.nlm.nih.gov/pubmed/9180687 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9501185 http://www.ncbi.nlm.nih.gov/pubmed/9501185 PubMed 9683493 http://www.ncbi.nlm.nih.gov/pubmed/9683493 RefSeq NP_415478 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415478 RefSeq WP_000288710 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000288710 SMR P0AFZ5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFZ5 STRING 511145.b0958 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0958&targetmode=cogs STRING COG5404 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG5404&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR00623 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00623 UniProtKB SULA_ECOLI http://www.uniprot.org/uniprot/SULA_ECOLI UniProtKB-AC P0AFZ5 http://www.uniprot.org/uniprot/P0AFZ5 charge swissprot:SULA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SULA_ECOLI eggNOG COG5404 http://eggnogapi.embl.de/nog_data/html/tree/COG5404 eggNOG ENOG4108ZD2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZD2 epestfind swissprot:SULA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SULA_ECOLI garnier swissprot:SULA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SULA_ECOLI helixturnhelix swissprot:SULA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SULA_ECOLI hmoment swissprot:SULA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SULA_ECOLI iep swissprot:SULA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SULA_ECOLI inforesidue swissprot:SULA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SULA_ECOLI octanol swissprot:SULA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SULA_ECOLI pepcoil swissprot:SULA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SULA_ECOLI pepdigest swissprot:SULA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SULA_ECOLI pepinfo swissprot:SULA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SULA_ECOLI pepnet swissprot:SULA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SULA_ECOLI pepstats swissprot:SULA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SULA_ECOLI pepwheel swissprot:SULA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SULA_ECOLI pepwindow swissprot:SULA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SULA_ECOLI sigcleave swissprot:SULA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SULA_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES YBHA_ECOLI Kinetic parameters KM=0.37 mM for PLP (in the presence of magnesium ion as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; KM=1.3 mM for Fru1,6bisP (in the presence of magnesium ion as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; pH dependence Optimum pH is between 6 and 7.5. {ECO 0000269|PubMed 16990279}; # BioGrid 4261146 12 # CATALYTIC ACTIVITY Pyridoxal 5'-phosphate + H(2)O = pyridoxal + phosphate. {ECO:0000269|PubMed 16990279}. # CAUTION This ORF is coded on the other strand of an ORF which has been called modD (by PubMed:7665460 and PubMed 8564363), but which seems to be wrong. {ECO:0000305}. # COFACTOR YBHA_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 16990279}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 16990279}; Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000269|PubMed 16990279}; Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 16990279}; Note=Magnesium. Can also use other divalent metal cations as manganese, cobalt or zinc. {ECO 0000269|PubMed 16990279}; # EcoGene EG11239 ybhA # FUNCTION YBHA_ECOLI Catalyzes the dephosphorylation of pyridoxal-phosphate (PLP). Can also hydrolyze erythrose-4-phosphate (Ery4P) and fructose-1,6-bis-phosphate (Fru1,6bisP). {ECO 0000269|PubMed 15808744, ECO 0000269|PubMed 16990279}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IDA:EcoliWiki. # GO_function GO:0016773 phosphotransferase activity, alcohol group as acceptor; IDA:EcoliWiki. # GO_function GO:0016791 phosphatase activity; IDA:EcoliWiki. # GO_function GO:0033883 pyridoxal phosphatase activity; IDA:EcoliWiki. # GO_function GO:0050308 sugar-phosphatase activity; IDA:EcoliWiki. # GO_process GO:0044283 small molecule biosynthetic process; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.1000 -; 2. # IntAct P21829 3 # InterPro IPR000150 Hypothet_cof # InterPro IPR006379 HAD-SF_hydro_IIB # InterPro IPR023214 HAD-like_dom # Organism YBHA_ECOLI Escherichia coli (strain K12) # PATRIC 32116733 VBIEscCol129921_0792 # PIR F64812 F64812 # PROSITE PS01228 COF_1 # PROSITE PS01229 COF_2 # Pfam PF08282 Hydrolase_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBHA_ECOLI Pyridoxal phosphate phosphatase YbhA # RefSeq NP_415287 NC_000913.3 # RefSeq WP_001300666 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=U07867; Type=Frameshift; Positions=217; Evidence={ECO 0000305}; # SIMILARITY Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. {ECO 0000305}. # SUPFAM SSF56784 SSF56784 # TIGRFAMs TIGR00099 Cof-subfamily # TIGRFAMs TIGR01484 HAD-SF-IIB # eggNOG COG0561 LUCA # eggNOG ENOG4108K4B Bacteria BLAST swissprot:YBHA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBHA_ECOLI BioCyc ECOL316407:JW0749-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0749-MONOMER BioCyc EcoCyc:EG11239-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11239-MONOMER BioCyc MetaCyc:EG11239-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11239-MONOMER COG COG0561 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0561 DOI 10.1016/j.fmrre.2004.12.006 http://dx.doi.org/10.1016/j.fmrre.2004.12.006 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M605449200 http://dx.doi.org/10.1074/jbc.M605449200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.3.74 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.74 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U07867 http://www.ebi.ac.uk/ena/data/view/U07867 EMBL U27192 http://www.ebi.ac.uk/ena/data/view/U27192 ENZYME 3.1.3.74 http://enzyme.expasy.org/EC/3.1.3.74 EchoBASE EB1221 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1221 EcoGene EG11239 http://www.ecogene.org/geneInfo.php?eg_id=EG11239 EnsemblBacteria AAC73853 http://www.ensemblgenomes.org/id/AAC73853 EnsemblBacteria AAC73853 http://www.ensemblgenomes.org/id/AAC73853 EnsemblBacteria BAA35430 http://www.ensemblgenomes.org/id/BAA35430 EnsemblBacteria BAA35430 http://www.ensemblgenomes.org/id/BAA35430 EnsemblBacteria BAA35430 http://www.ensemblgenomes.org/id/BAA35430 EnsemblBacteria b0766 http://www.ensemblgenomes.org/id/b0766 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0016773 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016773 GO_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GO_function GO:0033883 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033883 GO_function GO:0050308 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050308 GO_process GO:0044283 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044283 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.1000 http://www.cathdb.info/version/latest/superfamily/3.40.50.1000 GeneID 945372 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945372 HOGENOM HOG000184780 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000184780&db=HOGENOM6 InParanoid P21829 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P21829 IntAct P21829 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P21829* IntEnz 3.1.3.74 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.74 InterPro IPR000150 http://www.ebi.ac.uk/interpro/entry/IPR000150 InterPro IPR006379 http://www.ebi.ac.uk/interpro/entry/IPR006379 InterPro IPR023214 http://www.ebi.ac.uk/interpro/entry/IPR023214 KEGG_Gene ecj:JW0749 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0749 KEGG_Gene eco:b0766 http://www.genome.jp/dbget-bin/www_bget?eco:b0766 KEGG_Orthology KO:K07024 http://www.genome.jp/dbget-bin/www_bget?KO:K07024 OMA MTYRVIA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MTYRVIA PROSITE PS01228 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01228 PROSITE PS01229 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01229 PSORT swissprot:YBHA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBHA_ECOLI PSORT-B swissprot:YBHA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBHA_ECOLI PSORT2 swissprot:YBHA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBHA_ECOLI Pfam PF08282 http://pfam.xfam.org/family/PF08282 Phobius swissprot:YBHA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBHA_ECOLI PhylomeDB P21829 http://phylomedb.org/?seqid=P21829 ProteinModelPortal P21829 http://www.proteinmodelportal.org/query/uniprot/P21829 PubMed 15808744 http://www.ncbi.nlm.nih.gov/pubmed/15808744 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16990279 http://www.ncbi.nlm.nih.gov/pubmed/16990279 PubMed 7665460 http://www.ncbi.nlm.nih.gov/pubmed/7665460 PubMed 8564363 http://www.ncbi.nlm.nih.gov/pubmed/8564363 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415287 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415287 RefSeq WP_001300666 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300666 SMR P21829 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P21829 STRING 511145.b0766 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0766&targetmode=cogs STRING COG0561 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0561&targetmode=cogs SUPFAM SSF56784 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784 TIGRFAMs TIGR00099 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00099 TIGRFAMs TIGR01484 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01484 UniProtKB YBHA_ECOLI http://www.uniprot.org/uniprot/YBHA_ECOLI UniProtKB-AC P21829 http://www.uniprot.org/uniprot/P21829 charge swissprot:YBHA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBHA_ECOLI eggNOG COG0561 http://eggnogapi.embl.de/nog_data/html/tree/COG0561 eggNOG ENOG4108K4B http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108K4B epestfind swissprot:YBHA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBHA_ECOLI garnier swissprot:YBHA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBHA_ECOLI helixturnhelix swissprot:YBHA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBHA_ECOLI hmoment swissprot:YBHA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBHA_ECOLI iep swissprot:YBHA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBHA_ECOLI inforesidue swissprot:YBHA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBHA_ECOLI octanol swissprot:YBHA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBHA_ECOLI pepcoil swissprot:YBHA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBHA_ECOLI pepdigest swissprot:YBHA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBHA_ECOLI pepinfo swissprot:YBHA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBHA_ECOLI pepnet swissprot:YBHA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBHA_ECOLI pepstats swissprot:YBHA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBHA_ECOLI pepwheel swissprot:YBHA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBHA_ECOLI pepwindow swissprot:YBHA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBHA_ECOLI sigcleave swissprot:YBHA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBHA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262348 7 # CDD cd08238 sorbose_phosphate_red # EcoGene EG12976 yggP # GO_function GO:0008270 zinc ion binding; IEA:InterPro. # GO_function GO:0016491 oxidoreductase activity; IEA:UniProtKB-KW. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.720 -; 1. # Gene3D 3.90.180.10 -; 1. # InterPro IPR002085 ADH_SF_Zn-type # InterPro IPR011032 GroES-like # InterPro IPR013149 ADH_C # InterPro IPR013154 ADH_N # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR033915 SorE # Organism YGGP_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11695 PTHR11695 # PANTHER PTHR11695:SF551 PTHR11695:SF551 # PATRIC 32121276 VBIEscCol129921_3026 # Pfam PF00107 ADH_zinc_N # Pfam PF08240 ADH_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGGP_ECOLI Uncharacterized protein YggP # RefSeq WP_000853247 NZ_LN832404.1 # RefSeq YP_026187 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA69098.1; Type=Frameshift; Positions=88; Evidence={ECO:0000305}; Sequence=AAA69099.1; Type=Frameshift; Positions=88; Evidence={ECO 0000305}; # SIMILARITY To K.pneumoniae SorE. {ECO 0000305}. # SUPFAM SSF50129 SSF50129 # SUPFAM SSF51735 SSF51735 # eggNOG COG1063 LUCA # eggNOG ENOG4105DXH Bacteria BLAST swissprot:YGGP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGGP_ECOLI BioCyc ECOL316407:JW5477-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5477-MONOMER BioCyc EcoCyc:G7520-MONOMER http://biocyc.org/getid?id=EcoCyc:G7520-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2802 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2802 EcoGene EG12976 http://www.ecogene.org/geneInfo.php?eg_id=EG12976 EnsemblBacteria AAT48154 http://www.ensemblgenomes.org/id/AAT48154 EnsemblBacteria AAT48154 http://www.ensemblgenomes.org/id/AAT48154 EnsemblBacteria BAE76995 http://www.ensemblgenomes.org/id/BAE76995 EnsemblBacteria BAE76995 http://www.ensemblgenomes.org/id/BAE76995 EnsemblBacteria BAE76995 http://www.ensemblgenomes.org/id/BAE76995 EnsemblBacteria b4465 http://www.ensemblgenomes.org/id/b4465 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 Gene3D 3.90.180.10 http://www.cathdb.info/version/latest/superfamily/3.90.180.10 GeneID 2847686 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2847686 HOGENOM HOG000124436 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000124436&db=HOGENOM6 InParanoid P52048 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P52048 InterPro IPR002085 http://www.ebi.ac.uk/interpro/entry/IPR002085 InterPro IPR011032 http://www.ebi.ac.uk/interpro/entry/IPR011032 InterPro IPR013149 http://www.ebi.ac.uk/interpro/entry/IPR013149 InterPro IPR013154 http://www.ebi.ac.uk/interpro/entry/IPR013154 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR033915 http://www.ebi.ac.uk/interpro/entry/IPR033915 KEGG_Gene ecj:JW5477 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5477 KEGG_Gene eco:b4465 http://www.genome.jp/dbget-bin/www_bget?eco:b4465 OMA ARDGCLN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ARDGCLN PANTHER PTHR11695 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11695 PANTHER PTHR11695:SF551 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11695:SF551 PSORT swissprot:YGGP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGGP_ECOLI PSORT-B swissprot:YGGP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGGP_ECOLI PSORT2 swissprot:YGGP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGGP_ECOLI Pfam PF00107 http://pfam.xfam.org/family/PF00107 Pfam PF08240 http://pfam.xfam.org/family/PF08240 Phobius swissprot:YGGP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGGP_ECOLI PhylomeDB P52048 http://phylomedb.org/?seqid=P52048 ProteinModelPortal P52048 http://www.proteinmodelportal.org/query/uniprot/P52048 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000853247 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000853247 RefSeq YP_026187 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026187 STRING 511145.b4465 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4465&targetmode=cogs SUPFAM SSF50129 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50129 SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB YGGP_ECOLI http://www.uniprot.org/uniprot/YGGP_ECOLI UniProtKB-AC P52048 http://www.uniprot.org/uniprot/P52048 charge swissprot:YGGP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGGP_ECOLI eggNOG COG1063 http://eggnogapi.embl.de/nog_data/html/tree/COG1063 eggNOG ENOG4105DXH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DXH epestfind swissprot:YGGP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGGP_ECOLI garnier swissprot:YGGP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGGP_ECOLI helixturnhelix swissprot:YGGP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGGP_ECOLI hmoment swissprot:YGGP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGGP_ECOLI iep swissprot:YGGP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGGP_ECOLI inforesidue swissprot:YGGP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGGP_ECOLI octanol swissprot:YGGP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGGP_ECOLI pepcoil swissprot:YGGP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGGP_ECOLI pepdigest swissprot:YGGP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGGP_ECOLI pepinfo swissprot:YGGP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGGP_ECOLI pepnet swissprot:YGGP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGGP_ECOLI pepstats swissprot:YGGP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGGP_ECOLI pepwheel swissprot:YGGP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGGP_ECOLI pepwindow swissprot:YGGP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGGP_ECOLI sigcleave swissprot:YGGP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGGP_ECOLI ## Database ID URL or Descriptions # BioGrid 4259655 7 # EcoGene EG13670 ybhN # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR022791 L-PG_synthase/AglD # Organism YBHN_ECOLI Escherichia coli (strain K12) # PATRIC 32116777 VBIEscCol129921_0814 # PIR D64815 D64815 # Pfam PF03706 LPG_synthase_TM # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBHN_ECOLI Inner membrane protein YbhN # RefSeq NP_415309 NC_000913.3 # RefSeq WP_000045450 NZ_LN832404.1 # SIMILARITY To Synechocystis PCC 6803 slr0712. {ECO 0000305}. # SUBCELLULAR LOCATION YBHN_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 4.D.2.4 the glycosyl transferase 2 (gt2) family # eggNOG COG0392 LUCA # eggNOG ENOG4107UXM Bacteria BLAST swissprot:YBHN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBHN_ECOLI BioCyc ECOL316407:JW0771-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0771-MONOMER BioCyc EcoCyc:G6405-MONOMER http://biocyc.org/getid?id=EcoCyc:G6405-MONOMER COG COG0392 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0392 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3434 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3434 EcoGene EG13670 http://www.ecogene.org/geneInfo.php?eg_id=EG13670 EnsemblBacteria AAC73875 http://www.ensemblgenomes.org/id/AAC73875 EnsemblBacteria AAC73875 http://www.ensemblgenomes.org/id/AAC73875 EnsemblBacteria BAA35447 http://www.ensemblgenomes.org/id/BAA35447 EnsemblBacteria BAA35447 http://www.ensemblgenomes.org/id/BAA35447 EnsemblBacteria BAA35447 http://www.ensemblgenomes.org/id/BAA35447 EnsemblBacteria b0788 http://www.ensemblgenomes.org/id/b0788 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 945410 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945410 HOGENOM HOG000118089 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118089&db=HOGENOM6 InParanoid P75770 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75770 InterPro IPR022791 http://www.ebi.ac.uk/interpro/entry/IPR022791 KEGG_Gene ecj:JW0771 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0771 KEGG_Gene eco:b0788 http://www.genome.jp/dbget-bin/www_bget?eco:b0788 KEGG_Orthology KO:K07027 http://www.genome.jp/dbget-bin/www_bget?KO:K07027 OMA KVIRNYN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KVIRNYN PSORT swissprot:YBHN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBHN_ECOLI PSORT-B swissprot:YBHN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBHN_ECOLI PSORT2 swissprot:YBHN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBHN_ECOLI Pfam PF03706 http://pfam.xfam.org/family/PF03706 Phobius swissprot:YBHN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBHN_ECOLI PhylomeDB P75770 http://phylomedb.org/?seqid=P75770 ProteinModelPortal P75770 http://www.proteinmodelportal.org/query/uniprot/P75770 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415309 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415309 RefSeq WP_000045450 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000045450 STRING 511145.b0788 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0788&targetmode=cogs STRING COG0392 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0392&targetmode=cogs TCDB 4.D.2.4 http://www.tcdb.org/search/result.php?tc=4.D.2.4 UniProtKB YBHN_ECOLI http://www.uniprot.org/uniprot/YBHN_ECOLI UniProtKB-AC P75770 http://www.uniprot.org/uniprot/P75770 charge swissprot:YBHN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBHN_ECOLI eggNOG COG0392 http://eggnogapi.embl.de/nog_data/html/tree/COG0392 eggNOG ENOG4107UXM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107UXM epestfind swissprot:YBHN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBHN_ECOLI garnier swissprot:YBHN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBHN_ECOLI helixturnhelix swissprot:YBHN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBHN_ECOLI hmoment swissprot:YBHN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBHN_ECOLI iep swissprot:YBHN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBHN_ECOLI inforesidue swissprot:YBHN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBHN_ECOLI octanol swissprot:YBHN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBHN_ECOLI pepcoil swissprot:YBHN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBHN_ECOLI pepdigest swissprot:YBHN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBHN_ECOLI pepinfo swissprot:YBHN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBHN_ECOLI pepnet swissprot:YBHN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBHN_ECOLI pepstats swissprot:YBHN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBHN_ECOLI pepwheel swissprot:YBHN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBHN_ECOLI pepwindow swissprot:YBHN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBHN_ECOLI sigcleave swissprot:YBHN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBHN_ECOLI ## Database ID URL or Descriptions # AltName ASCG_ECOLI Cryptic asc operon repressor # BioGrid 4259426 8 # CDD cd01392 HTH_LacI # EcoGene EG10087 ascG # FUNCTION ASCG_ECOLI Repressor of the asc operon. The cryptic operon is activated by the insertion of IS186 into the ascG gene. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IDA:EcoCyc. # GO_function GO:0043565 sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEP:EcoCyc. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.260.40 -; 1. # IntAct P24242 14 # InterPro IPR000843 HTH_LacI # InterPro IPR010982 Lambda_DNA-bd_dom # InterPro IPR028082 Peripla_BP_I # KEGG_Brite ko03000 Transcription factors # Organism ASCG_ECOLI Escherichia coli (strain K12) # PATRIC 32120828 VBIEscCol129921_2806 # PDB 3BRQ X-ray; 2.00 A; A/B=43-336 # PDB 3DBI X-ray; 2.45 A; A/B/C=2-336 # PIR F65051 F65051 # PROSITE PS00356 HTH_LACI_1 # PROSITE PS50932 HTH_LACI_2 # Pfam PF00356 LacI # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ASCG_ECOLI HTH-type transcriptional regulator AscG # RefSeq NP_417194 NC_000913.3 # RefSeq WP_001394680 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA16428.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAA69224.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=BAE76791.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; # SIMILARITY Contains 1 HTH lacI-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00111}. # SMART SM00354 HTH_LACI # SUPFAM SSF47413 SSF47413 # SUPFAM SSF53822 SSF53822 # eggNOG COG1609 LUCA # eggNOG ENOG4105DDV Bacteria BLAST swissprot:ASCG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ASCG_ECOLI BioCyc ECOL316407:JW5434-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5434-MONOMER BioCyc EcoCyc:EG10087-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10087-MONOMER COG COG1609 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1609 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M73326 http://www.ebi.ac.uk/ena/data/view/M73326 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EchoBASE EB0085 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0085 EcoGene EG10087 http://www.ecogene.org/geneInfo.php?eg_id=EG10087 EnsemblBacteria AAC75756 http://www.ensemblgenomes.org/id/AAC75756 EnsemblBacteria AAC75756 http://www.ensemblgenomes.org/id/AAC75756 EnsemblBacteria BAE76791 http://www.ensemblgenomes.org/id/BAE76791 EnsemblBacteria BAE76791 http://www.ensemblgenomes.org/id/BAE76791 EnsemblBacteria BAE76791 http://www.ensemblgenomes.org/id/BAE76791 EnsemblBacteria b2714 http://www.ensemblgenomes.org/id/b2714 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.260.40 http://www.cathdb.info/version/latest/superfamily/1.10.260.40 GeneID 947305 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947305 HOGENOM HOG000220179 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220179&db=HOGENOM6 InParanoid P24242 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P24242 IntAct P24242 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P24242* InterPro IPR000843 http://www.ebi.ac.uk/interpro/entry/IPR000843 InterPro IPR010982 http://www.ebi.ac.uk/interpro/entry/IPR010982 InterPro IPR028082 http://www.ebi.ac.uk/interpro/entry/IPR028082 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW5434 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5434 KEGG_Gene eco:b2714 http://www.genome.jp/dbget-bin/www_bget?eco:b2714 KEGG_Orthology KO:K03487 http://www.genome.jp/dbget-bin/www_bget?KO:K03487 OMA HGVYFSE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HGVYFSE PDB 3BRQ http://www.ebi.ac.uk/pdbe-srv/view/entry/3BRQ PDB 3DBI http://www.ebi.ac.uk/pdbe-srv/view/entry/3DBI PDBsum 3BRQ http://www.ebi.ac.uk/pdbsum/3BRQ PDBsum 3DBI http://www.ebi.ac.uk/pdbsum/3DBI PROSITE PS00356 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00356 PROSITE PS50932 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50932 PSORT swissprot:ASCG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ASCG_ECOLI PSORT-B swissprot:ASCG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ASCG_ECOLI PSORT2 swissprot:ASCG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ASCG_ECOLI Pfam PF00356 http://pfam.xfam.org/family/PF00356 Phobius swissprot:ASCG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ASCG_ECOLI ProteinModelPortal P24242 http://www.proteinmodelportal.org/query/uniprot/P24242 PubMed 1630307 http://www.ncbi.nlm.nih.gov/pubmed/1630307 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417194 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417194 RefSeq WP_001394680 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001394680 SMART SM00354 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00354 SMR P24242 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P24242 STRING 511145.b2714 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2714&targetmode=cogs STRING COG1609 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1609&targetmode=cogs SUPFAM SSF47413 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47413 SUPFAM SSF53822 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822 UniProtKB ASCG_ECOLI http://www.uniprot.org/uniprot/ASCG_ECOLI UniProtKB-AC P24242 http://www.uniprot.org/uniprot/P24242 charge swissprot:ASCG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ASCG_ECOLI eggNOG COG1609 http://eggnogapi.embl.de/nog_data/html/tree/COG1609 eggNOG ENOG4105DDV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DDV epestfind swissprot:ASCG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ASCG_ECOLI garnier swissprot:ASCG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ASCG_ECOLI helixturnhelix swissprot:ASCG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ASCG_ECOLI hmoment swissprot:ASCG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ASCG_ECOLI iep swissprot:ASCG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ASCG_ECOLI inforesidue swissprot:ASCG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ASCG_ECOLI octanol swissprot:ASCG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ASCG_ECOLI pepcoil swissprot:ASCG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ASCG_ECOLI pepdigest swissprot:ASCG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ASCG_ECOLI pepinfo swissprot:ASCG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ASCG_ECOLI pepnet swissprot:ASCG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ASCG_ECOLI pepstats swissprot:ASCG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ASCG_ECOLI pepwheel swissprot:ASCG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ASCG_ECOLI pepwindow swissprot:ASCG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ASCG_ECOLI sigcleave swissprot:ASCG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ASCG_ECOLI ## Database ID URL or Descriptions # BioGrid 4259961 7 # EcoGene EG12406 ybiH # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IBA:GO_Central. # GO_process GO:0006351 transcription, DNA-templated; ISS:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IBA:GO_Central. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.60 -; 1. # Gene3D 1.10.357.10 -; 1. # INTERACTION YBIH_ECOLI Self; NbExp=2; IntAct=EBI-1114129, EBI-1114129; # IntAct P0ACU0 10 # InterPro IPR001647 HTH_TetR # InterPro IPR009057 Homeodomain-like # InterPro IPR011075 Tet_transcr_reg_TetR-rel_C # InterPro IPR015292 Tscrpt_reg_YbiH_C # InterPro IPR015893 Tet_transcr_reg_TetR-like_C # InterPro IPR023772 DNA-bd_HTH_TetR-type_CS # Organism YBIH_ECOLI Escherichia coli (strain K12) # PATRIC 32116793 VBIEscCol129921_0822 # PRINTS PR00455 HTHTETR # PROSITE PS01081 HTH_TETR_1 # PROSITE PS50977 HTH_TETR_2 # Pfam PF00440 TetR_N # Pfam PF09209 DUF1956 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBIH_ECOLI Uncharacterized HTH-type transcriptional regulator YbiH # RefSeq NP_415317 NC_000913.3 # RefSeq WP_001296991 NZ_LN832404.1 # SIMILARITY Contains 1 HTH tetR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00335}. # SUPFAM SSF46689 SSF46689 # SUPFAM SSF48498 SSF48498 # eggNOG COG1309 LUCA # eggNOG ENOG4107MVR Bacteria BLAST swissprot:YBIH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBIH_ECOLI BioCyc ECOL316407:JW0780-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0780-MONOMER BioCyc EcoCyc:EG12406-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12406-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1266/jjg.69.1 http://dx.doi.org/10.1266/jjg.69.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L02123 http://www.ebi.ac.uk/ena/data/view/L02123 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2306 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2306 EcoGene EG12406 http://www.ecogene.org/geneInfo.php?eg_id=EG12406 EnsemblBacteria AAC73883 http://www.ensemblgenomes.org/id/AAC73883 EnsemblBacteria AAC73883 http://www.ensemblgenomes.org/id/AAC73883 EnsemblBacteria BAA35456 http://www.ensemblgenomes.org/id/BAA35456 EnsemblBacteria BAA35456 http://www.ensemblgenomes.org/id/BAA35456 EnsemblBacteria BAA35456 http://www.ensemblgenomes.org/id/BAA35456 EnsemblBacteria b0796 http://www.ensemblgenomes.org/id/b0796 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 Gene3D 1.10.357.10 http://www.cathdb.info/version/latest/superfamily/1.10.357.10 GeneID 945421 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945421 HOGENOM HOG000118101 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118101&db=HOGENOM6 InParanoid P0ACU0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACU0 IntAct P0ACU0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACU0* InterPro IPR001647 http://www.ebi.ac.uk/interpro/entry/IPR001647 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR011075 http://www.ebi.ac.uk/interpro/entry/IPR011075 InterPro IPR015292 http://www.ebi.ac.uk/interpro/entry/IPR015292 InterPro IPR015893 http://www.ebi.ac.uk/interpro/entry/IPR015893 InterPro IPR023772 http://www.ebi.ac.uk/interpro/entry/IPR023772 KEGG_Gene ecj:JW0780 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0780 KEGG_Gene eco:b0796 http://www.genome.jp/dbget-bin/www_bget?eco:b0796 OMA SPTDAYP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SPTDAYP PRINTS PR00455 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00455 PROSITE PS01081 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01081 PROSITE PS50977 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50977 PSORT swissprot:YBIH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBIH_ECOLI PSORT-B swissprot:YBIH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBIH_ECOLI PSORT2 swissprot:YBIH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBIH_ECOLI Pfam PF00440 http://pfam.xfam.org/family/PF00440 Pfam PF09209 http://pfam.xfam.org/family/PF09209 Phobius swissprot:YBIH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBIH_ECOLI ProteinModelPortal P0ACU0 http://www.proteinmodelportal.org/query/uniprot/P0ACU0 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8037924 http://www.ncbi.nlm.nih.gov/pubmed/8037924 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415317 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415317 RefSeq WP_001296991 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001296991 SMR P0ACU0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACU0 STRING 511145.b0796 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0796&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF48498 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48498 UniProtKB YBIH_ECOLI http://www.uniprot.org/uniprot/YBIH_ECOLI UniProtKB-AC P0ACU0 http://www.uniprot.org/uniprot/P0ACU0 charge swissprot:YBIH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBIH_ECOLI eggNOG COG1309 http://eggnogapi.embl.de/nog_data/html/tree/COG1309 eggNOG ENOG4107MVR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107MVR epestfind swissprot:YBIH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBIH_ECOLI garnier swissprot:YBIH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBIH_ECOLI helixturnhelix swissprot:YBIH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBIH_ECOLI hmoment swissprot:YBIH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBIH_ECOLI iep swissprot:YBIH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBIH_ECOLI inforesidue swissprot:YBIH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBIH_ECOLI octanol swissprot:YBIH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBIH_ECOLI pepcoil swissprot:YBIH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBIH_ECOLI pepdigest swissprot:YBIH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBIH_ECOLI pepinfo swissprot:YBIH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBIH_ECOLI pepnet swissprot:YBIH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBIH_ECOLI pepstats swissprot:YBIH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBIH_ECOLI pepwheel swissprot:YBIH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBIH_ECOLI pepwindow swissprot:YBIH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBIH_ECOLI sigcleave swissprot:YBIH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBIH_ECOLI ## Database ID URL or Descriptions # BioGrid 4260364 230 # EcoGene EG11808 yebG # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_process GO:0006281 DNA repair; IEP:EcoCyc. # GO_process GO:0009432 SOS response; IEP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # Gene3D 1.10.10.710 -; 1. # IntAct P0ACY9 12 # InterPro IPR009813 Uncharacterised_YebG # Organism YEBG_ECOLI Escherichia coli (strain K12) # PATRIC 32119017 VBIEscCol129921_1926 # PIR H64946 H64946 # Pfam PF07130 YebG # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEBG_ECOLI Uncharacterized protein YebG # RefSeq NP_416362 NC_000913.3 # RefSeq WP_000257738 NZ_LN832404.1 # eggNOG COG3141 LUCA # eggNOG ENOG4105X2V Bacteria BLAST swissprot:YEBG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEBG_ECOLI BioCyc ECOL316407:JW1837-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1837-MONOMER BioCyc EcoCyc:EG11808-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11808-MONOMER COG COG3141 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3141 DIP DIP-48077N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48077N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L20897 http://www.ebi.ac.uk/ena/data/view/L20897 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1756 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1756 EcoGene EG11808 http://www.ecogene.org/geneInfo.php?eg_id=EG11808 EnsemblBacteria AAC74918 http://www.ensemblgenomes.org/id/AAC74918 EnsemblBacteria AAC74918 http://www.ensemblgenomes.org/id/AAC74918 EnsemblBacteria BAA15654 http://www.ensemblgenomes.org/id/BAA15654 EnsemblBacteria BAA15654 http://www.ensemblgenomes.org/id/BAA15654 EnsemblBacteria BAA15654 http://www.ensemblgenomes.org/id/BAA15654 EnsemblBacteria b1848 http://www.ensemblgenomes.org/id/b1848 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_process GO:0006281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006281 GO_process GO:0009432 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009432 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 1.10.10.710 http://www.cathdb.info/version/latest/superfamily/1.10.10.710 GeneID 946364 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946364 HOGENOM HOG000277795 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000277795&db=HOGENOM6 InParanoid P0ACY9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACY9 IntAct P0ACY9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACY9* InterPro IPR009813 http://www.ebi.ac.uk/interpro/entry/IPR009813 KEGG_Gene ecj:JW1837 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1837 KEGG_Gene eco:b1848 http://www.genome.jp/dbget-bin/www_bget?eco:b1848 KEGG_Orthology KO:K09918 http://www.genome.jp/dbget-bin/www_bget?KO:K09918 MINT MINT-1246516 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1246516 OMA QMDETQA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QMDETQA PSORT swissprot:YEBG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEBG_ECOLI PSORT-B swissprot:YEBG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEBG_ECOLI PSORT2 swissprot:YEBG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEBG_ECOLI Pfam PF07130 http://pfam.xfam.org/family/PF07130 Phobius swissprot:YEBG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEBG_ECOLI ProteinModelPortal P0ACY9 http://www.proteinmodelportal.org/query/uniprot/P0ACY9 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416362 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416362 RefSeq WP_000257738 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000257738 SMR P0ACY9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACY9 STRING 511145.b1848 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1848&targetmode=cogs STRING COG3141 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3141&targetmode=cogs UniProtKB YEBG_ECOLI http://www.uniprot.org/uniprot/YEBG_ECOLI UniProtKB-AC P0ACY9 http://www.uniprot.org/uniprot/P0ACY9 charge swissprot:YEBG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEBG_ECOLI eggNOG COG3141 http://eggnogapi.embl.de/nog_data/html/tree/COG3141 eggNOG ENOG4105X2V http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105X2V epestfind swissprot:YEBG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEBG_ECOLI garnier swissprot:YEBG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEBG_ECOLI helixturnhelix swissprot:YEBG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEBG_ECOLI hmoment swissprot:YEBG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEBG_ECOLI iep swissprot:YEBG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEBG_ECOLI inforesidue swissprot:YEBG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEBG_ECOLI octanol swissprot:YEBG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEBG_ECOLI pepcoil swissprot:YEBG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEBG_ECOLI pepdigest swissprot:YEBG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEBG_ECOLI pepinfo swissprot:YEBG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEBG_ECOLI pepnet swissprot:YEBG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEBG_ECOLI pepstats swissprot:YEBG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEBG_ECOLI pepwheel swissprot:YEBG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEBG_ECOLI pepwindow swissprot:YEBG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEBG_ECOLI sigcleave swissprot:YEBG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEBG_ECOLI ## Database ID URL or Descriptions # AltName LACY_ECOLI Lactose-proton symport # BioGrid 4263185 7 # CDD cd06174 MFS # EcoGene EG10526 lacY # FUNCTION LACY_ECOLI Responsible for transport of beta-galactosides into the cell, with the concomitant import of a proton (symport system). # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:EcoliWiki. # GO_component GO:0016021 integral component of membrane; IDA:EcoliWiki. # GO_function GO:0030395 lactose binding; IDA:EcoliWiki. # GO_function LACY_ECOLI GO 0005351 sugar proton symporter activity; IDA EcoliWiki. # GO_function LACY_ECOLI GO 0015528 lactose proton symporter activity; IMP CACAO. # GO_process GO:0008643 carbohydrate transport; IMP:CACAO. # GO_process GO:0015767 lactose transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR000576 LacY/RafB_perm_fam # InterPro IPR018457 LacY/RafB_perm_fam_CS # InterPro IPR020846 MFS_dom # KEGG_Brite ko02000 Transporters # MASS SPECTROMETRY Mass=47357; Method=Electrospray; Range=1-417; Evidence={ECO:0000269|PubMed 10485888}; # Organism LACY_ECOLI Escherichia coli (strain K12) # PATRIC 32115819 VBIEscCol129921_0351 # PDB 1M2U Model; -; A=1-417 # PDB 1PV6 X-ray; 3.50 A; A/B=1-417 # PDB 1PV7 X-ray; 3.60 A; A/B=1-417 # PDB 2CFP X-ray; 3.30 A; A=1-417 # PDB 2CFQ X-ray; 2.95 A; A=1-417 # PDB 2V8N X-ray; 3.60 A; A/B=1-417 # PDB 2Y5Y X-ray; 3.38 A; A/B=1-417 # PDB 4ZYR X-ray; 3.31 A; A/B=1-417 # PIR A03418 GREC # PRINTS PR00174 LACYSMPORT # PROSITE PS00896 LACY_1 # PROSITE PS00897 LACY_2 # PROSITE PS50850 MFS # Pfam PF01306 LacY_symp # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LACY_ECOLI Lactose permease # RefSeq NP_414877 NC_000913.3 # RefSeq WP_000291549 NZ_LN832404.1 # SIMILARITY Belongs to the LacY/RafB permease family. {ECO 0000305}. # SUBCELLULAR LOCATION LACY_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT LACY_ECOLI Monomer. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.5 the major facilitator superfamily (mfs) # TIGRFAMs TIGR00882 2A0105 # eggNOG ENOG4105U0F Bacteria # eggNOG ENOG410XQTD LUCA BLAST swissprot:LACY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LACY_ECOLI BioCyc ECOL316407:JW0334-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0334-MONOMER BioCyc EcoCyc:LACY-MONOMER http://biocyc.org/getid?id=EcoCyc:LACY-MONOMER BioCyc MetaCyc:LACY-MONOMER http://biocyc.org/getid?id=MetaCyc:LACY-MONOMER COG COG0477 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0477 DIP DIP-10080N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10080N DOI 10.1016/0005-2728(90)90239-Z http://dx.doi.org/10.1016/0005-2728(90)90239-Z DOI 10.1016/0005-2736(91)90390-T http://dx.doi.org/10.1016/0005-2736(91)90390-T DOI 10.1021/bi00045a036 http://dx.doi.org/10.1021/bi00045a036 DOI 10.1038/283541a0 http://dx.doi.org/10.1038/283541a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.87.13.4937 http://dx.doi.org/10.1073/pnas.87.13.4937 DOI 10.1073/pnas.96.19.10695 http://dx.doi.org/10.1073/pnas.96.19.10695 DOI 10.1126/science.1088196 http://dx.doi.org/10.1126/science.1088196 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01636 http://www.ebi.ac.uk/ena/data/view/J01636 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EMBL V00295 http://www.ebi.ac.uk/ena/data/view/V00295 EMBL X56095 http://www.ebi.ac.uk/ena/data/view/X56095 EchoBASE EB0521 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0521 EcoGene EG10526 http://www.ecogene.org/geneInfo.php?eg_id=EG10526 EnsemblBacteria AAC73446 http://www.ensemblgenomes.org/id/AAC73446 EnsemblBacteria AAC73446 http://www.ensemblgenomes.org/id/AAC73446 EnsemblBacteria BAE76125 http://www.ensemblgenomes.org/id/BAE76125 EnsemblBacteria BAE76125 http://www.ensemblgenomes.org/id/BAE76125 EnsemblBacteria BAE76125 http://www.ensemblgenomes.org/id/BAE76125 EnsemblBacteria b0343 http://www.ensemblgenomes.org/id/b0343 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005351 GO_function GO:0015528 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015528 GO_function GO:0030395 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030395 GO_process GO:0008643 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008643 GO_process GO:0015767 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015767 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 949083 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949083 HOGENOM HOG000114363 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000114363&db=HOGENOM6 InParanoid P02920 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P02920 InterPro IPR000576 http://www.ebi.ac.uk/interpro/entry/IPR000576 InterPro IPR018457 http://www.ebi.ac.uk/interpro/entry/IPR018457 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0334 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0334 KEGG_Gene eco:b0343 http://www.genome.jp/dbget-bin/www_bget?eco:b0343 KEGG_Orthology KO:K02532 http://www.genome.jp/dbget-bin/www_bget?KO:K02532 OMA IVGCFKY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IVGCFKY PDB 1M2U http://www.ebi.ac.uk/pdbe-srv/view/entry/1M2U PDB 1PV6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1PV6 PDB 1PV7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1PV7 PDB 2CFP http://www.ebi.ac.uk/pdbe-srv/view/entry/2CFP PDB 2CFQ http://www.ebi.ac.uk/pdbe-srv/view/entry/2CFQ PDB 2V8N http://www.ebi.ac.uk/pdbe-srv/view/entry/2V8N PDB 2Y5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/2Y5Y PDB 4ZYR http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZYR PDBsum 1M2U http://www.ebi.ac.uk/pdbsum/1M2U PDBsum 1PV6 http://www.ebi.ac.uk/pdbsum/1PV6 PDBsum 1PV7 http://www.ebi.ac.uk/pdbsum/1PV7 PDBsum 2CFP http://www.ebi.ac.uk/pdbsum/2CFP PDBsum 2CFQ http://www.ebi.ac.uk/pdbsum/2CFQ PDBsum 2V8N http://www.ebi.ac.uk/pdbsum/2V8N PDBsum 2Y5Y http://www.ebi.ac.uk/pdbsum/2Y5Y PDBsum 4ZYR http://www.ebi.ac.uk/pdbsum/4ZYR PRINTS PR00174 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00174 PROSITE PS00896 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00896 PROSITE PS00897 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00897 PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:LACY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LACY_ECOLI PSORT-B swissprot:LACY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LACY_ECOLI PSORT2 swissprot:LACY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LACY_ECOLI Pfam PF01306 http://pfam.xfam.org/family/PF01306 Phobius swissprot:LACY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LACY_ECOLI PhylomeDB P02920 http://phylomedb.org/?seqid=P02920 ProteinModelPortal P02920 http://www.proteinmodelportal.org/query/uniprot/P02920 PubMed 10485888 http://www.ncbi.nlm.nih.gov/pubmed/10485888 PubMed 12893935 http://www.ncbi.nlm.nih.gov/pubmed/12893935 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 1644770 http://www.ncbi.nlm.nih.gov/pubmed/1644770 PubMed 16453726 http://www.ncbi.nlm.nih.gov/pubmed/16453726 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1848449 http://www.ncbi.nlm.nih.gov/pubmed/1848449 PubMed 2164211 http://www.ncbi.nlm.nih.gov/pubmed/2164211 PubMed 2203471 http://www.ncbi.nlm.nih.gov/pubmed/2203471 PubMed 6444453 http://www.ncbi.nlm.nih.gov/pubmed/6444453 PubMed 7578103 http://www.ncbi.nlm.nih.gov/pubmed/7578103 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414877 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414877 RefSeq WP_000291549 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000291549 SMR P02920 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P02920 STRING 511145.b0343 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0343&targetmode=cogs STRING COG0477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0477&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.5 http://www.tcdb.org/search/result.php?tc=2.A.1.5 TIGRFAMs TIGR00882 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00882 UniProtKB LACY_ECOLI http://www.uniprot.org/uniprot/LACY_ECOLI UniProtKB-AC P02920 http://www.uniprot.org/uniprot/P02920 charge swissprot:LACY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LACY_ECOLI eggNOG ENOG4105U0F http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105U0F eggNOG ENOG410XQTD http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQTD epestfind swissprot:LACY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LACY_ECOLI garnier swissprot:LACY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LACY_ECOLI helixturnhelix swissprot:LACY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LACY_ECOLI hmoment swissprot:LACY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LACY_ECOLI iep swissprot:LACY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LACY_ECOLI inforesidue swissprot:LACY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LACY_ECOLI octanol swissprot:LACY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LACY_ECOLI pepcoil swissprot:LACY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LACY_ECOLI pepdigest swissprot:LACY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LACY_ECOLI pepinfo swissprot:LACY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LACY_ECOLI pepnet swissprot:LACY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LACY_ECOLI pepstats swissprot:LACY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LACY_ECOLI pepwheel swissprot:LACY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LACY_ECOLI pepwindow swissprot:LACY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LACY_ECOLI sigcleave swissprot:LACY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LACY_ECOLI ## Database ID URL or Descriptions # BioGrid 4260167 9 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG13367 ydaY # IntAct P76069 16 # Organism YDAY_ECOLI Escherichia coli (strain K12) # PATRIC 48662023 VBIEscCol107702_1375 # PIR A64887 A64887 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDAY_ECOLI Putative uncharacterized protein YdaY # RefSeq WP_000091628 NZ_CP014272.1 BLAST swissprot:YDAY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDAY_ECOLI BioCyc ECOL316407:JW1360-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1360-MONOMER BioCyc EcoCyc:G6689-MONOMER http://biocyc.org/getid?id=EcoCyc:G6689-MONOMER DIP DIP-11630N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11630N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3150 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3150 EcoGene EG13367 http://www.ecogene.org/geneInfo.php?eg_id=EG13367 EnsemblBacteria BAE76418 http://www.ensemblgenomes.org/id/BAE76418 EnsemblBacteria BAE76418 http://www.ensemblgenomes.org/id/BAE76418 EnsemblBacteria BAE76418 http://www.ensemblgenomes.org/id/BAE76418 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv HOGENOM HOG000120431 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120431&db=HOGENOM6 IntAct P76069 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76069* KEGG_Gene ecj:JW1360 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1360 MINT MINT-1275440 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1275440 OMA RRHIDKM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RRHIDKM PSORT swissprot:YDAY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDAY_ECOLI PSORT-B swissprot:YDAY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDAY_ECOLI PSORT2 swissprot:YDAY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDAY_ECOLI Phobius swissprot:YDAY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDAY_ECOLI ProteinModelPortal P76069 http://www.proteinmodelportal.org/query/uniprot/P76069 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000091628 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000091628 STRING 316407.85674929 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85674929&targetmode=cogs UniProtKB YDAY_ECOLI http://www.uniprot.org/uniprot/YDAY_ECOLI UniProtKB-AC P76069 http://www.uniprot.org/uniprot/P76069 charge swissprot:YDAY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDAY_ECOLI epestfind swissprot:YDAY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDAY_ECOLI garnier swissprot:YDAY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDAY_ECOLI helixturnhelix swissprot:YDAY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDAY_ECOLI hmoment swissprot:YDAY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDAY_ECOLI iep swissprot:YDAY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDAY_ECOLI inforesidue swissprot:YDAY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDAY_ECOLI octanol swissprot:YDAY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDAY_ECOLI pepcoil swissprot:YDAY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDAY_ECOLI pepdigest swissprot:YDAY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDAY_ECOLI pepinfo swissprot:YDAY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDAY_ECOLI pepnet swissprot:YDAY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDAY_ECOLI pepstats swissprot:YDAY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDAY_ECOLI pepwheel swissprot:YDAY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDAY_ECOLI pepwindow swissprot:YDAY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDAY_ECOLI sigcleave swissprot:YDAY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDAY_ECOLI ## Database ID URL or Descriptions # InterPro IPR004914 Antirestrict # Organism YUBI_ECOLI Escherichia coli (strain K12) # Pfam PF03230 Antirestrict # ProDom PD012854 Antirestrict # RecName YUBI_ECOLI Putative antirestriction protein YubI # RefSeq NP_061436 NC_002483.1 # RefSeq WP_001198920 NZ_CP014273.1 # SIMILARITY Belongs to the antirestriction protein family. {ECO 0000305}. BLAST swissprot:YUBI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YUBI_ECOLI DOI 10.1006/plas.1999.1390 http://dx.doi.org/10.1006/plas.1999.1390 EMBL AF106329 http://www.ebi.ac.uk/ena/data/view/AF106329 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1263597 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263597 InterPro IPR004914 http://www.ebi.ac.uk/interpro/entry/IPR004914 OMA GNAGLTH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GNAGLTH PSORT swissprot:YUBI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YUBI_ECOLI PSORT-B swissprot:YUBI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YUBI_ECOLI PSORT2 swissprot:YUBI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YUBI_ECOLI Pfam PF03230 http://pfam.xfam.org/family/PF03230 Phobius swissprot:YUBI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YUBI_ECOLI ProteinModelPortal Q9S4W7 http://www.proteinmodelportal.org/query/uniprot/Q9S4W7 PubMed 10366527 http://www.ncbi.nlm.nih.gov/pubmed/10366527 RefSeq NP_061436 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061436 RefSeq WP_001198920 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001198920 SMR Q9S4W7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9S4W7 UniProtKB YUBI_ECOLI http://www.uniprot.org/uniprot/YUBI_ECOLI UniProtKB-AC Q9S4W7 http://www.uniprot.org/uniprot/Q9S4W7 charge swissprot:YUBI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YUBI_ECOLI epestfind swissprot:YUBI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YUBI_ECOLI garnier swissprot:YUBI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YUBI_ECOLI helixturnhelix swissprot:YUBI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YUBI_ECOLI hmoment swissprot:YUBI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YUBI_ECOLI iep swissprot:YUBI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YUBI_ECOLI inforesidue swissprot:YUBI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YUBI_ECOLI octanol swissprot:YUBI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YUBI_ECOLI pepcoil swissprot:YUBI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YUBI_ECOLI pepdigest swissprot:YUBI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YUBI_ECOLI pepinfo swissprot:YUBI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YUBI_ECOLI pepnet swissprot:YUBI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YUBI_ECOLI pepstats swissprot:YUBI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YUBI_ECOLI pepwheel swissprot:YUBI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YUBI_ECOLI pepwindow swissprot:YUBI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YUBI_ECOLI sigcleave swissprot:YUBI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YUBI_ECOLI ## Database ID URL or Descriptions # AltName EIICBA-Mtl {ECO:0000303|PubMed 368051} # AltName PTS system mannitol-specific EIIA component {ECO:0000303|PubMed 368051} # AltName PTS system mannitol-specific EIIB component {ECO:0000303|PubMed 368051} # AltName PTS system mannitol-specific EIIB component {ECO:0000303|PubMed 368051} # AltName PTS system mannitol-specific EIIC component {ECO:0000303|PubMed 368051} # AltName PTS system mannitol-specific EIIC component {ECO:0000303|PubMed 368051} # BIOPHYSICOCHEMICAL PROPERTIES PTM3C_ECOLI Kinetic parameters KM=66 uM for mannitol phosphorylation {ECO 0000269|PubMed 2123863}; Vmax=21.7 nmol/min/mg enzyme toward mannitol {ECO 0000269|PubMed 2123863}; # BioGrid 4260741 9 # CATALYTIC ACTIVITY PTM3C_ECOLI [Protein]-N(pi)-phospho-L-histidine + D- mannitol(Side 1) = [protein]-L-histidine + D-mannitol 1- phosphate(Side 2). {ECO 0000269|PubMed 2123863, ECO 0000305|PubMed 368051}. # CDD cd05567 PTS_IIB_mannitol # DOMAIN PTM3C_ECOLI The EIIC type-2 domain forms the PTS system translocation channel and contains the specific substrate-binding site. {ECO 0000255|PROSITE-ProRule PRU00427}. # DOMAIN PTM3C_ECOLI The PTS EIIA type-2 domain is phosphorylated by phospho- HPr on a histidyl residue. Then, it transfers the phosphoryl group to the PTS EIIB type-2 domain. {ECO 0000255|PROSITE- ProRule PRU00417}. # DOMAIN PTM3C_ECOLI The PTS EIIB type-2 domain is phosphorylated by phospho- EIIA on a cysteinyl residue. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the PTS EIIC type-2 domain. {ECO 0000255|PROSITE- ProRule PRU00422}. # EcoGene EG10615 mtlA # FUNCTION PTM3C_ECOLI The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in D-mannitol transport (PubMed 368051, PubMed 6427236, PubMed 2123863). Also able to use D-mannonic acid (PubMed 6427236). {ECO 0000269|PubMed 2123863, ECO 0000269|PubMed 368051, ECO 0000269|PubMed 6427236}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_function GO:0016301 kinase activity; IEA:UniProtKB-KW. # GO_function GO:0022872 protein-N(PI)-phosphohistidine-mannitol phosphotransferase system transmembrane transporter activity; IEA:InterPro. # GO_function GO:0090565 protein-phosphocysteine-mannitol phosphotransferase system transporter activity; IDA:EcoCyc. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IDA:EcoCyc. # GO_process GO:0015797 mannitol transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # Gene3D 3.40.50.10370 -; 1. # Gene3D 3.40.930.10 -; 1. # INDUCTION Induced by mannitol. Repressed by MltR. {ECO:0000269|PubMed 8300537}. # IntAct P00550 2 # InterPro IPR002178 PTS_EIIA_type-2_dom # InterPro IPR003352 PTS_EIIC # InterPro IPR003501 PTS_EIIB_2/3 # InterPro IPR004718 PTS_IIC_mtl # InterPro IPR013011 PTS_EIIB_2 # InterPro IPR013014 PTS_EIIC_2 # InterPro IPR016152 PTrfase/Anion_transptr # InterPro IPR029503 PTS_EIIB_mannitol # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00274 PTS system, mannitol-specific II component # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko00051 Fructose and mannose metabolism # KEGG_Pathway ko02060 Phosphotransferase system (PTS) # Organism PTM3C_ECOLI Escherichia coli (strain K12) # PATRIC 32122681 VBIEscCol129921_3717 # PDB 1A3A X-ray; 1.80 A; A/B/C/D=491-637 # PDB 1J6T NMR; -; A=491-637 # PDB 1VKR NMR; -; A=367-489 # PDB 1VRV NMR; -; A=375-475 # PDB 2FEW NMR; -; A=491-637, B=375-475 # PIR A00661 WQEC2M # PROSITE PS00372 PTS_EIIA_TYPE_2_HIS # PROSITE PS51094 PTS_EIIA_TYPE_2 # PROSITE PS51099 PTS_EIIB_TYPE_2 # PROSITE PS51104 PTS_EIIC_TYPE_2 # PTM PTM3C_ECOLI An intramolecular phosphotransfer takes places between His- 554 and Cys-384. {ECO 0000305|PubMed 16443929}. # Pfam PF00359 PTS_EIIA_2 # Pfam PF02302 PTS_IIB # Pfam PF02378 PTS_EIIC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Mannitol permease IIC component {ECO:0000303|PubMed 368051} # RecName Mannitol-specific phosphotransferase enzyme IIA component {ECO:0000303|PubMed 368051} # RecName Mannitol-specific phosphotransferase enzyme IIB component {ECO:0000303|PubMed 368051} # RecName PTS system mannitol-specific EIICBA component {ECO:0000303|PubMed 368051} # RefSeq NP_418056 NC_000913.3 # RefSeq WP_000093247 NZ_CP014272.1 # SIMILARITY Contains 1 PTS EIIA type-2 domain. {ECO:0000255|PROSITE-ProRule PRU00417}. # SIMILARITY Contains 1 PTS EIIB type-2 domain. {ECO:0000255|PROSITE-ProRule PRU00422}. # SIMILARITY Contains 1 PTS EIIC type-2 domain. {ECO:0000255|PROSITE-ProRule PRU00427}. # SUBCELLULAR LOCATION PTM3C_ECOLI Cell inner membrane {ECO 0000255|PROSITE- ProRule PRU00427, ECO 0000269|PubMed 15919996, ECO 0000305|PubMed 6309813}; Multi-pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00427, ECO 0000269|PubMed 15919996, ECO 0000305|PubMed 368051}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 3322385}. # SUPFAM SSF52794 SSF52794 # SUPFAM SSF55804 SSF55804 # TCDB 4.A.2.1 the pts fructose-mannitol (fru) family # TIGRFAMs TIGR00851 mtlA # eggNOG COG2213 LUCA # eggNOG COG4668 LUCA # eggNOG ENOG4105CTS Bacteria BLAST swissprot:PTM3C_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTM3C_ECOLI BioCyc ECOL316407:JW3573-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3573-MONOMER BioCyc EcoCyc:MTLA-MONOMER http://biocyc.org/getid?id=EcoCyc:MTLA-MONOMER BioCyc MetaCyc:MTLA-MONOMER http://biocyc.org/getid?id=MetaCyc:MTLA-MONOMER COG COG2213 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2213 DIP DIP-10267N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10267N DOI 10.1002/jcb.240230120 http://dx.doi.org/10.1002/jcb.240230120 DOI 10.1016/S0969-2126(98)00039-2 http://dx.doi.org/10.1016/S0969-2126(98)00039-2 DOI 10.1021/bi00395a019 http://dx.doi.org/10.1021/bi00395a019 DOI 10.1021/bi00416a002 http://dx.doi.org/10.1021/bi00416a002 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.88.21.9603 http://dx.doi.org/10.1073/pnas.88.21.9603 DOI 10.1074/jbc.M207314200 http://dx.doi.org/10.1074/jbc.M207314200 DOI 10.1074/jbc.M406764200 http://dx.doi.org/10.1074/jbc.M406764200 DOI 10.1074/jbc.M513466200 http://dx.doi.org/10.1074/jbc.M513466200 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1111/j.1365-2958.1988.tb00045.x http://dx.doi.org/10.1111/j.1365-2958.1988.tb00045.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.197 {ECO:0000269|PubMed:2123863, ECO:0000305|PubMed:368051} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.197 {ECO:0000269|PubMed:2123863, ECO:0000305|PubMed:368051} EC_number EC:2.7.1.197 {ECO:0000269|PubMed:2123863, ECO:0000305|PubMed:368051} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.197 {ECO:0000269|PubMed:2123863, ECO:0000305|PubMed:368051} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V01503 http://www.ebi.ac.uk/ena/data/view/V01503 EMBL X06794 http://www.ebi.ac.uk/ena/data/view/X06794 ENZYME 2.7.1.197 {ECO:0000269|PubMed:2123863, ECO:0000305|PubMed:368051} http://enzyme.expasy.org/EC/2.7.1.197 {ECO:0000269|PubMed:2123863, ECO:0000305|PubMed:368051} ENZYME 2.7.1.197 {ECO:0000269|PubMed:2123863, ECO:0000305|PubMed:368051} http://enzyme.expasy.org/EC/2.7.1.197 {ECO:0000269|PubMed:2123863, ECO:0000305|PubMed:368051} EchoBASE EB0610 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0610 EcoGene EG10615 http://www.ecogene.org/geneInfo.php?eg_id=EG10615 EnsemblBacteria AAC76623 http://www.ensemblgenomes.org/id/AAC76623 EnsemblBacteria AAC76623 http://www.ensemblgenomes.org/id/AAC76623 EnsemblBacteria BAE77694 http://www.ensemblgenomes.org/id/BAE77694 EnsemblBacteria BAE77694 http://www.ensemblgenomes.org/id/BAE77694 EnsemblBacteria BAE77694 http://www.ensemblgenomes.org/id/BAE77694 EnsemblBacteria b3599 http://www.ensemblgenomes.org/id/b3599 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_function GO:0022872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022872 GO_function GO:0090565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090565 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GO_process GO:0015797 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015797 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.40.50.10370 http://www.cathdb.info/version/latest/superfamily/3.40.50.10370 Gene3D 3.40.930.10 http://www.cathdb.info/version/latest/superfamily/3.40.930.10 GeneID 948118 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948118 HOGENOM HOG000252814 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000252814&db=HOGENOM6 InParanoid P00550 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00550 IntAct P00550 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00550* IntEnz 2.7.1.197 {ECO:0000269|PubMed:2123863, ECO:0000305|PubMed:368051} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.197 {ECO:0000269|PubMed:2123863, ECO:0000305|PubMed:368051} IntEnz 2.7.1.197 {ECO:0000269|PubMed:2123863, ECO:0000305|PubMed:368051} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.197 {ECO:0000269|PubMed:2123863, ECO:0000305|PubMed:368051} InterPro IPR002178 http://www.ebi.ac.uk/interpro/entry/IPR002178 InterPro IPR003352 http://www.ebi.ac.uk/interpro/entry/IPR003352 InterPro IPR003501 http://www.ebi.ac.uk/interpro/entry/IPR003501 InterPro IPR004718 http://www.ebi.ac.uk/interpro/entry/IPR004718 InterPro IPR013011 http://www.ebi.ac.uk/interpro/entry/IPR013011 InterPro IPR013014 http://www.ebi.ac.uk/interpro/entry/IPR013014 InterPro IPR016152 http://www.ebi.ac.uk/interpro/entry/IPR016152 InterPro IPR029503 http://www.ebi.ac.uk/interpro/entry/IPR029503 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3573 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3573 KEGG_Gene eco:b3599 http://www.genome.jp/dbget-bin/www_bget?eco:b3599 KEGG_Orthology KO:K02800 http://www.genome.jp/dbget-bin/www_bget?KO:K02800 KEGG_Pathway ko00051 http://www.genome.jp/kegg-bin/show_pathway?ko00051 KEGG_Pathway ko02060 http://www.genome.jp/kegg-bin/show_pathway?ko02060 KEGG_Reaction rn:R02704 http://www.genome.jp/dbget-bin/www_bget?rn:R02704 MINT MINT-245984 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-245984 OMA GWAIKRF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GWAIKRF PDB 1A3A http://www.ebi.ac.uk/pdbe-srv/view/entry/1A3A PDB 1J6T http://www.ebi.ac.uk/pdbe-srv/view/entry/1J6T PDB 1VKR http://www.ebi.ac.uk/pdbe-srv/view/entry/1VKR PDB 1VRV http://www.ebi.ac.uk/pdbe-srv/view/entry/1VRV PDB 2FEW http://www.ebi.ac.uk/pdbe-srv/view/entry/2FEW PDBsum 1A3A http://www.ebi.ac.uk/pdbsum/1A3A PDBsum 1J6T http://www.ebi.ac.uk/pdbsum/1J6T PDBsum 1VKR http://www.ebi.ac.uk/pdbsum/1VKR PDBsum 1VRV http://www.ebi.ac.uk/pdbsum/1VRV PDBsum 2FEW http://www.ebi.ac.uk/pdbsum/2FEW PROSITE PS00372 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00372 PROSITE PS51094 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51094 PROSITE PS51099 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51099 PROSITE PS51104 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51104 PSORT swissprot:PTM3C_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTM3C_ECOLI PSORT-B swissprot:PTM3C_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTM3C_ECOLI PSORT2 swissprot:PTM3C_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTM3C_ECOLI Pfam PF00359 http://pfam.xfam.org/family/PF00359 Pfam PF02302 http://pfam.xfam.org/family/PF02302 Pfam PF02378 http://pfam.xfam.org/family/PF02378 Phobius swissprot:PTM3C_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTM3C_ECOLI PhylomeDB P00550 http://phylomedb.org/?seqid=P00550 ProteinModelPortal P00550 http://www.proteinmodelportal.org/query/uniprot/P00550 PubMed 12202490 http://www.ncbi.nlm.nih.gov/pubmed/12202490 PubMed 15258141 http://www.ncbi.nlm.nih.gov/pubmed/15258141 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16443929 http://www.ncbi.nlm.nih.gov/pubmed/16443929 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1946374 http://www.ncbi.nlm.nih.gov/pubmed/1946374 PubMed 2123863 http://www.ncbi.nlm.nih.gov/pubmed/2123863 PubMed 2407724 http://www.ncbi.nlm.nih.gov/pubmed/2407724 PubMed 3135464 http://www.ncbi.nlm.nih.gov/pubmed/3135464 PubMed 3142516 http://www.ncbi.nlm.nih.gov/pubmed/3142516 PubMed 3322385 http://www.ncbi.nlm.nih.gov/pubmed/3322385 PubMed 368051 http://www.ncbi.nlm.nih.gov/pubmed/368051 PubMed 6309813 http://www.ncbi.nlm.nih.gov/pubmed/6309813 PubMed 6427236 http://www.ncbi.nlm.nih.gov/pubmed/6427236 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 8300537 http://www.ncbi.nlm.nih.gov/pubmed/8300537 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9551558 http://www.ncbi.nlm.nih.gov/pubmed/9551558 RefSeq NP_418056 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418056 RefSeq WP_000093247 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000093247 SMR P00550 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00550 STRING 511145.b3599 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3599&targetmode=cogs STRING COG2213 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2213&targetmode=cogs SUPFAM SSF52794 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52794 SUPFAM SSF55804 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55804 TCDB 4.A.2.1 http://www.tcdb.org/search/result.php?tc=4.A.2.1 TIGRFAMs TIGR00851 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00851 UniProtKB PTM3C_ECOLI http://www.uniprot.org/uniprot/PTM3C_ECOLI UniProtKB-AC P00550 http://www.uniprot.org/uniprot/P00550 charge swissprot:PTM3C_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTM3C_ECOLI eggNOG COG2213 http://eggnogapi.embl.de/nog_data/html/tree/COG2213 eggNOG COG4668 http://eggnogapi.embl.de/nog_data/html/tree/COG4668 eggNOG ENOG4105CTS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CTS epestfind swissprot:PTM3C_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTM3C_ECOLI garnier swissprot:PTM3C_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTM3C_ECOLI helixturnhelix swissprot:PTM3C_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTM3C_ECOLI hmoment swissprot:PTM3C_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTM3C_ECOLI iep swissprot:PTM3C_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTM3C_ECOLI inforesidue swissprot:PTM3C_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTM3C_ECOLI octanol swissprot:PTM3C_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTM3C_ECOLI pepcoil swissprot:PTM3C_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTM3C_ECOLI pepdigest swissprot:PTM3C_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTM3C_ECOLI pepinfo swissprot:PTM3C_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTM3C_ECOLI pepnet swissprot:PTM3C_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTM3C_ECOLI pepstats swissprot:PTM3C_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTM3C_ECOLI pepwheel swissprot:PTM3C_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTM3C_ECOLI pepwindow swissprot:PTM3C_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTM3C_ECOLI sigcleave swissprot:PTM3C_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTM3C_ECOLI ## Database ID URL or Descriptions # BioGrid 4261866 4 # EcoGene EG11497 prmA # FUNCTION PRMA_ECOLI Methylates ribosomal protein L11. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0016279 protein-lysine N-methyltransferase activity; IDA:EcoCyc. # GO_process GO:0018012 N-terminal peptidyl-alanine trimethylation; IMP:EcoCyc. # GO_process GO:0018023 peptidyl-lysine trimethylation; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0006464 cellular protein modification process # Gene3D 3.40.50.150 -; 1. # HAMAP MF_00735 Methyltr_PrmA # INTERACTION PRMA_ECOLI P0A7J7 rplK; NbExp=3; IntAct=EBI-556300, EBI-547288; # IntAct P0A8T1 14 # InterPro IPR004498 Ribosomal_PrmA_MeTrfase # InterPro IPR029063 SAM-dependent_MTases # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # Organism PRMA_ECOLI Escherichia coli (strain K12) # PATRIC 32121948 VBIEscCol129921_3358 # PIR E65118 E65118 # PIRSF PIRSF000401 RPL11_MTase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PRMA_ECOLI Ribosomal protein L11 methyltransferase # RefSeq NP_417725 NC_000913.3 # RefSeq WP_001145827 NZ_LN832404.1 # SIMILARITY Belongs to the methyltransferase superfamily. PrmA family. {ECO 0000305}. # SUBCELLULAR LOCATION PRMA_ECOLI Cytoplasm. # SUPFAM SSF53335 SSF53335 # TIGRFAMs TIGR00406 prmA # eggNOG COG2264 LUCA # eggNOG ENOG4105F59 Bacteria BLAST swissprot:PRMA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PRMA_ECOLI BioCyc ECOL316407:JW3227-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3227-MONOMER BioCyc EcoCyc:EG11497-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11497-MONOMER BioCyc MetaCyc:EG11497-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11497-MONOMER COG COG2264 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2264 DIP DIP-47862N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47862N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1994.tb01330.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb01330.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M30953 http://www.ebi.ac.uk/ena/data/view/M30953 EMBL M95784 http://www.ebi.ac.uk/ena/data/view/M95784 EMBL S67010 http://www.ebi.ac.uk/ena/data/view/S67010 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 2.1.1.- http://enzyme.expasy.org/EC/2.1.1.- EchoBASE EB1460 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1460 EcoGene EG11497 http://www.ecogene.org/geneInfo.php?eg_id=EG11497 EnsemblBacteria AAC76291 http://www.ensemblgenomes.org/id/AAC76291 EnsemblBacteria AAC76291 http://www.ensemblgenomes.org/id/AAC76291 EnsemblBacteria BAE77300 http://www.ensemblgenomes.org/id/BAE77300 EnsemblBacteria BAE77300 http://www.ensemblgenomes.org/id/BAE77300 EnsemblBacteria BAE77300 http://www.ensemblgenomes.org/id/BAE77300 EnsemblBacteria b3259 http://www.ensemblgenomes.org/id/b3259 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0016279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016279 GO_process GO:0018012 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018012 GO_process GO:0018023 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018023 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 GeneID 947708 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947708 HAMAP MF_00735 http://hamap.expasy.org/unirule/MF_00735 HOGENOM HOG000007390 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000007390&db=HOGENOM6 InParanoid P0A8T1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8T1 IntAct P0A8T1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8T1* IntEnz 2.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1 InterPro IPR004498 http://www.ebi.ac.uk/interpro/entry/IPR004498 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW3227 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3227 KEGG_Gene eco:b3259 http://www.genome.jp/dbget-bin/www_bget?eco:b3259 KEGG_Orthology KO:K02687 http://www.genome.jp/dbget-bin/www_bget?KO:K02687 MINT MINT-1232840 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1232840 OMA FVHKIEQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FVHKIEQ PSORT swissprot:PRMA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PRMA_ECOLI PSORT-B swissprot:PRMA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PRMA_ECOLI PSORT2 swissprot:PRMA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PRMA_ECOLI Phobius swissprot:PRMA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PRMA_ECOLI PhylomeDB P0A8T1 http://phylomedb.org/?seqid=P0A8T1 ProteinModelPortal P0A8T1 http://www.proteinmodelportal.org/query/uniprot/P0A8T1 PubMed 1459953 http://www.ncbi.nlm.nih.gov/pubmed/1459953 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2193919 http://www.ncbi.nlm.nih.gov/pubmed/2193919 PubMed 7715456 http://www.ncbi.nlm.nih.gov/pubmed/7715456 PubMed 8226664 http://www.ncbi.nlm.nih.gov/pubmed/8226664 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417725 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417725 RefSeq WP_001145827 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001145827 SMR P0A8T1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8T1 STRING 511145.b3259 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3259&targetmode=cogs STRING COG2264 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2264&targetmode=cogs SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 TIGRFAMs TIGR00406 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00406 UniProtKB PRMA_ECOLI http://www.uniprot.org/uniprot/PRMA_ECOLI UniProtKB-AC P0A8T1 http://www.uniprot.org/uniprot/P0A8T1 charge swissprot:PRMA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PRMA_ECOLI eggNOG COG2264 http://eggnogapi.embl.de/nog_data/html/tree/COG2264 eggNOG ENOG4105F59 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F59 epestfind swissprot:PRMA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PRMA_ECOLI garnier swissprot:PRMA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PRMA_ECOLI helixturnhelix swissprot:PRMA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PRMA_ECOLI hmoment swissprot:PRMA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PRMA_ECOLI iep swissprot:PRMA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PRMA_ECOLI inforesidue swissprot:PRMA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PRMA_ECOLI octanol swissprot:PRMA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PRMA_ECOLI pepcoil swissprot:PRMA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PRMA_ECOLI pepdigest swissprot:PRMA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PRMA_ECOLI pepinfo swissprot:PRMA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PRMA_ECOLI pepnet swissprot:PRMA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PRMA_ECOLI pepstats swissprot:PRMA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PRMA_ECOLI pepwheel swissprot:PRMA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PRMA_ECOLI pepwindow swissprot:PRMA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PRMA_ECOLI sigcleave swissprot:PRMA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PRMA_ECOLI ## Database ID URL or Descriptions # AltName MEPS_ECOLI Lipoprotein Spr # AltName MEPS_ECOLI Murein hydrolase MepS # BioGrid 4261093 195 # CATALYTIC ACTIVITY MEPS_ECOLI GlcNAc-MurNAc-L-alanyl-gamma-D-glutamyl-meso- diaminopimelyl-D-alanine + H(2)O = GlcNAc-MurNAc-L-alanyl-gamma-D- glutamyl-meso-diaminopimelate + D-alanine. # DISRUPTION PHENOTYPE MEPS_ECOLI Unable to grow on nutrient agar at 42 degrees Celsius. A triple mepS-mepH-mepM mutant is inviable, whereas a double mepS-mepM will grow on a nutrient-poor medium but not on a rich medium, suggesting the 3 endopeptidases are functionally redundant in vivo. Depletion experiments of the double or triple mutants lead to cell lysis, as well as significantly decreased incorporation of mDAP into peptidogylcan sacculi and increased amounts of the enzyme's substrate (Tetra- Tetra-anhydro muropeptide). {ECO 0000269|PubMed 23062283, ECO 0000269|PubMed 9158724}. # EcoGene EG14076 mepS # FUNCTION MEPS_ECOLI A murein DD-endopeptidase with specificity for D-Ala- meso-diaminopimelic acid (mDAP) cross-links. Its role is probably to cleave D-Ala-mDAP cross-links to allow insertion of new glycans and thus cell wall expansion. Functionally redundant with MepM and MepH. Also has weak LD-carboxypeptidase activity on L-mDAP-D-Ala peptide bonds. Partially suppresses a prc disruption mutant. {ECO 0000269|PubMed 23062283, ECO 0000269|PubMed 9158724}. # GO_component GO:0009279 cell outer membrane; IEA:UniProtKB-SubCell. # GO_function GO:0004175 endopeptidase activity; IDA:EcoCyc. # GO_function GO:0008234 cysteine-type peptidase activity; IEA:UniProtKB-KW. # GO_process GO:0000270 peptidoglycan metabolic process; IDA:EcoCyc. # GO_process GO:0009254 peptidoglycan turnover; IMP:CACAO. # GO_process GO:0045227 capsule polysaccharide biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0008233 peptidase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 3.90.1720.10 -; 1. # IntAct P0AFV4 8 # InterPro IPR000064 NLP_P60_dom # KEGG_Brite ko01002 Peptidases # Organism MEPS_ECOLI Escherichia coli (strain K12) # PATHWAY MEPS_ECOLI Cell wall biogenesis; cell wall polysaccharide biosynthesis. # PATRIC 32119705 VBIEscCol129921_2263 # PDB 2K1G NMR; -; A=63-188 # PIR F64986 F64986 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF00877 NLPC_P60 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MEPS_ECOLI Murein DD-endopeptidase MepS/Murein LD-carboxypeptidase # RefSeq NP_416680 NC_000913.3 # RefSeq WP_000241011 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase C40 family. {ECO 0000305}. # SUBCELLULAR LOCATION MEPS_ECOLI Cell outer membrane {ECO 0000305}; Lipid- anchor {ECO 0000255|PROSITE-ProRule PRU00303}. # SUBUNIT Monomer. {ECO 0000305}. # eggNOG COG0791 LUCA # eggNOG ENOG4107TT5 Bacteria BLAST swissprot:MEPS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MEPS_ECOLI BioCyc ECOL316407:JW2163-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2163-MONOMER BioCyc EcoCyc:G7147-MONOMER http://biocyc.org/getid?id=EcoCyc:G7147-MONOMER BioCyc MetaCyc:G7147-MONOMER http://biocyc.org/getid?id=MetaCyc:G7147-MONOMER COG COG0791 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0791 DOI 10.1021/bi8010779 http://dx.doi.org/10.1021/bi8010779 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1089/mdr.1996.2.63 http://dx.doi.org/10.1089/mdr.1996.2.63 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1111/mmi.12058 http://dx.doi.org/10.1111/mmi.12058 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.4.-.- EC_number EC:3.4.17.13 http://www.genome.jp/dbget-bin/www_bget?EC:3.4.17.13 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D86610 http://www.ebi.ac.uk/ena/data/view/D86610 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.4.-.- http://enzyme.expasy.org/EC/3.4.-.- ENZYME 3.4.17.13 http://enzyme.expasy.org/EC/3.4.17.13 EchoBASE EB3829 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3829 EcoGene EG14076 http://www.ecogene.org/geneInfo.php?eg_id=EG14076 EnsemblBacteria AAC75236 http://www.ensemblgenomes.org/id/AAC75236 EnsemblBacteria AAC75236 http://www.ensemblgenomes.org/id/AAC75236 EnsemblBacteria BAA15983 http://www.ensemblgenomes.org/id/BAA15983 EnsemblBacteria BAA15983 http://www.ensemblgenomes.org/id/BAA15983 EnsemblBacteria BAA15983 http://www.ensemblgenomes.org/id/BAA15983 EnsemblBacteria b2175 http://www.ensemblgenomes.org/id/b2175 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_function GO:0004175 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004175 GO_function GO:0008234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008234 GO_process GO:0000270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000270 GO_process GO:0009254 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009254 GO_process GO:0045227 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045227 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 3.90.1720.10 http://www.cathdb.info/version/latest/superfamily/3.90.1720.10 GeneID 946686 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946686 HOGENOM HOG000229978 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000229978&db=HOGENOM6 InParanoid P0AFV4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFV4 IntAct P0AFV4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFV4* IntEnz 3.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4 IntEnz 3.4.17.13 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.17.13 InterPro IPR000064 http://www.ebi.ac.uk/interpro/entry/IPR000064 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW2163 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2163 KEGG_Gene eco:b2175 http://www.genome.jp/dbget-bin/www_bget?eco:b2175 KEGG_Orthology KO:K13694 http://www.genome.jp/dbget-bin/www_bget?KO:K13694 OMA WASRYMG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WASRYMG PDB 2K1G http://www.ebi.ac.uk/pdbe-srv/view/entry/2K1G PDBsum 2K1G http://www.ebi.ac.uk/pdbsum/2K1G PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:MEPS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MEPS_ECOLI PSORT-B swissprot:MEPS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MEPS_ECOLI PSORT2 swissprot:MEPS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MEPS_ECOLI Pfam PF00877 http://pfam.xfam.org/family/PF00877 Phobius swissprot:MEPS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MEPS_ECOLI PhylomeDB P0AFV4 http://phylomedb.org/?seqid=P0AFV4 ProteinModelPortal P0AFV4 http://www.proteinmodelportal.org/query/uniprot/P0AFV4 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18715016 http://www.ncbi.nlm.nih.gov/pubmed/18715016 PubMed 23062283 http://www.ncbi.nlm.nih.gov/pubmed/23062283 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9158724 http://www.ncbi.nlm.nih.gov/pubmed/9158724 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416680 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416680 RefSeq WP_000241011 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000241011 SMR P0AFV4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFV4 STRING 511145.b2175 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2175&targetmode=cogs STRING COG0791 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0791&targetmode=cogs UniProtKB MEPS_ECOLI http://www.uniprot.org/uniprot/MEPS_ECOLI UniProtKB-AC P0AFV4 http://www.uniprot.org/uniprot/P0AFV4 charge swissprot:MEPS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MEPS_ECOLI eggNOG COG0791 http://eggnogapi.embl.de/nog_data/html/tree/COG0791 eggNOG ENOG4107TT5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107TT5 epestfind swissprot:MEPS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MEPS_ECOLI garnier swissprot:MEPS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MEPS_ECOLI helixturnhelix swissprot:MEPS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MEPS_ECOLI hmoment swissprot:MEPS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MEPS_ECOLI iep swissprot:MEPS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MEPS_ECOLI inforesidue swissprot:MEPS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MEPS_ECOLI octanol swissprot:MEPS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MEPS_ECOLI pepcoil swissprot:MEPS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MEPS_ECOLI pepdigest swissprot:MEPS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MEPS_ECOLI pepinfo swissprot:MEPS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MEPS_ECOLI pepnet swissprot:MEPS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MEPS_ECOLI pepstats swissprot:MEPS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MEPS_ECOLI pepwheel swissprot:MEPS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MEPS_ECOLI pepwindow swissprot:MEPS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MEPS_ECOLI sigcleave swissprot:MEPS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MEPS_ECOLI ## Database ID URL or Descriptions # AltName XGPT_ECOLI Xanthine-guanine phosphoribosyltransferase # BIOPHYSICOCHEMICAL PROPERTIES XGPT_ECOLI Kinetic parameters KM=4.3 uM for guanine {ECO 0000269|PubMed 3886014, ECO 0000269|PubMed 9100006}; KM=30.5 uM for xanthine {ECO 0000269|PubMed 3886014, ECO 0000269|PubMed 9100006}; KM=90.8 uM for hypoxanthine {ECO 0000269|PubMed 3886014, ECO 0000269|PubMed 9100006}; # BRENDA 2.4.2.22 2026 # BioGrid 4260989 8 # CATALYTIC ACTIVITY XGPT_ECOLI XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine. # CDD cd06223 PRTases_typeI # COFACTOR XGPT_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 9100006}; Note=Binds 1 Mg(2+) ion per subunit. {ECO 0000269|PubMed 9100006}; # ENZYME REGULATION Inhibited by thioguanine, GMP and, to a lesser extent, by thioxanthine, azaxanthine and azaguanine. {ECO:0000269|PubMed 3886014}. # EcoGene EG10414 gpt # FUNCTION XGPT_ECOLI Acts on guanine, xanthine and to a lesser extent hypoxanthine. {ECO 0000269|PubMed 9100006}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0000310 xanthine phosphoribosyltransferase activity; IDA:EcoCyc. # GO_function GO:0004422 hypoxanthine phosphoribosyltransferase activity; IDA:EcoCyc. # GO_process GO:0032263 GMP salvage; IMP:EcoCyc. # GO_process GO:0032264 IMP salvage; IDA:EcoCyc. # GO_process GO:0032265 XMP salvage; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.2020 -; 1. # HAMAP MF_01903 XGPRT # InterPro IPR000836 PRibTrfase_dom # InterPro IPR023747 Xanthine_Guanine_PRibTrfase # InterPro IPR029057 PRTase-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # MASS SPECTROMETRY Mass=16805; Method=API; Range=1-152; Note=The measured mass is that of mutant Ala-59.; Evidence={ECO:0000269|PubMed 9100006}; # Organism XGPT_ECOLI Escherichia coli (strain K12) # PATHWAY Purine metabolism; XMP biosynthesis via salvage pathway; XMP from xanthine step 1/1. # PATRIC 32115591 VBIEscCol129921_0240 # PDB 1A95 X-ray; 2.00 A; A/B/C/D=1-152 # PDB 1A96 X-ray; 2.00 A; A/B/C/D=1-152 # PDB 1A97 X-ray; 2.60 A; A/B/C/D=3-150 # PDB 1A98 X-ray; 2.25 A; A/B=1-152 # PDB 1NUL X-ray; 1.80 A; A/B=1-152 # PIR A00587 RTECGX # PROSITE PS00103 PUR_PYR_PR_TRANSFER # Pfam PF00156 Pribosyltran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName XGPT_ECOLI Xanthine phosphoribosyltransferase # RefSeq NP_414773 NC_000913.3 # RefSeq WP_001291990 NZ_LN832404.1 # SIMILARITY Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION XGPT_ECOLI Cell inner membrane {ECO 0000305}; Peripheral membrane protein {ECO 0000305}. # SUBUNIT XGPT_ECOLI Homotetramer. {ECO 0000269|PubMed 9100006, ECO 0000269|PubMed 9743633}. # SUPFAM SSF53271 SSF53271 # UniPathway UPA00602 UER00658 # eggNOG COG0503 LUCA BLAST swissprot:XGPT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:XGPT_ECOLI BioCyc ECOL316407:JW0228-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0228-MONOMER BioCyc EcoCyc:GPT-MONOMER http://biocyc.org/getid?id=EcoCyc:GPT-MONOMER BioCyc MetaCyc:GPT-MONOMER http://biocyc.org/getid?id=MetaCyc:GPT-MONOMER COG COG0503 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0503 DOI 10.1006/jmbi.1998.2051 http://dx.doi.org/10.1006/jmbi.1998.2051 DOI 10.1006/jsbi.1996.0050 http://dx.doi.org/10.1006/jsbi.1996.0050 DOI 10.1016/0304-4165(85)90003-0 http://dx.doi.org/10.1016/0304-4165(85)90003-0 DOI 10.1016/0378-1119(84)90052-0 http://dx.doi.org/10.1016/0378-1119(84)90052-0 DOI 10.1016/0378-1119(84)90228-2 http://dx.doi.org/10.1016/0378-1119(84)90228-2 DOI 10.1021/bi962640d http://dx.doi.org/10.1021/bi962640d DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.84.2.344 http://dx.doi.org/10.1073/pnas.84.2.344 DOI 10.1093/nar/11.24.8809 http://dx.doi.org/10.1093/nar/11.24.8809 DOI 10.1093/nar/11.24.8817 http://dx.doi.org/10.1093/nar/11.24.8817 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/MCB.1.5.449 http://dx.doi.org/10.1128/MCB.1.5.449 EC_number EC:2.4.2.22 http://www.genome.jp/dbget-bin/www_bget?EC:2.4.2.22 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M10382 http://www.ebi.ac.uk/ena/data/view/M10382 EMBL M12907 http://www.ebi.ac.uk/ena/data/view/M12907 EMBL M13422 http://www.ebi.ac.uk/ena/data/view/M13422 EMBL M15035 http://www.ebi.ac.uk/ena/data/view/M15035 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EMBL X00221 http://www.ebi.ac.uk/ena/data/view/X00221 EMBL X00222 http://www.ebi.ac.uk/ena/data/view/X00222 ENZYME 2.4.2.22 http://enzyme.expasy.org/EC/2.4.2.22 EchoBASE EB0409 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0409 EcoGene EG10414 http://www.ecogene.org/geneInfo.php?eg_id=EG10414 EnsemblBacteria AAC73342 http://www.ensemblgenomes.org/id/AAC73342 EnsemblBacteria AAC73342 http://www.ensemblgenomes.org/id/AAC73342 EnsemblBacteria BAA77907 http://www.ensemblgenomes.org/id/BAA77907 EnsemblBacteria BAA77907 http://www.ensemblgenomes.org/id/BAA77907 EnsemblBacteria BAA77907 http://www.ensemblgenomes.org/id/BAA77907 EnsemblBacteria b0238 http://www.ensemblgenomes.org/id/b0238 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0000310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000310 GO_function GO:0004422 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004422 GO_process GO:0032263 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032263 GO_process GO:0032264 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032264 GO_process GO:0032265 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032265 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.2020 http://www.cathdb.info/version/latest/superfamily/3.40.50.2020 GeneID 944817 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944817 HAMAP MF_01903 http://hamap.expasy.org/unirule/MF_01903 HOGENOM HOG000226805 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000226805&db=HOGENOM6 InParanoid P0A9M5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9M5 IntAct P0A9M5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9M5* IntEnz 2.4.2.22 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.2.22 InterPro IPR000836 http://www.ebi.ac.uk/interpro/entry/IPR000836 InterPro IPR023747 http://www.ebi.ac.uk/interpro/entry/IPR023747 InterPro IPR029057 http://www.ebi.ac.uk/interpro/entry/IPR029057 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0228 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0228 KEGG_Gene eco:b0238 http://www.genome.jp/dbget-bin/www_bget?eco:b0238 KEGG_Orthology KO:K00769 http://www.genome.jp/dbget-bin/www_bget?KO:K00769 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Reaction rn:R01229 http://www.genome.jp/dbget-bin/www_bget?rn:R01229 KEGG_Reaction rn:R02142 http://www.genome.jp/dbget-bin/www_bget?rn:R02142 OMA FHRDCRA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FHRDCRA PDB 1A95 http://www.ebi.ac.uk/pdbe-srv/view/entry/1A95 PDB 1A96 http://www.ebi.ac.uk/pdbe-srv/view/entry/1A96 PDB 1A97 http://www.ebi.ac.uk/pdbe-srv/view/entry/1A97 PDB 1A98 http://www.ebi.ac.uk/pdbe-srv/view/entry/1A98 PDB 1NUL http://www.ebi.ac.uk/pdbe-srv/view/entry/1NUL PDBsum 1A95 http://www.ebi.ac.uk/pdbsum/1A95 PDBsum 1A96 http://www.ebi.ac.uk/pdbsum/1A96 PDBsum 1A97 http://www.ebi.ac.uk/pdbsum/1A97 PDBsum 1A98 http://www.ebi.ac.uk/pdbsum/1A98 PDBsum 1NUL http://www.ebi.ac.uk/pdbsum/1NUL PROSITE PS00103 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00103 PSORT swissprot:XGPT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:XGPT_ECOLI PSORT-B swissprot:XGPT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:XGPT_ECOLI PSORT2 swissprot:XGPT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:XGPT_ECOLI Pfam PF00156 http://pfam.xfam.org/family/PF00156 Phobius swissprot:XGPT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:XGPT_ECOLI PhylomeDB P0A9M5 http://phylomedb.org/?seqid=P0A9M5 ProteinModelPortal P0A9M5 http://www.proteinmodelportal.org/query/uniprot/P0A9M5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3540961 http://www.ncbi.nlm.nih.gov/pubmed/3540961 PubMed 3886014 http://www.ncbi.nlm.nih.gov/pubmed/3886014 PubMed 6100966 http://www.ncbi.nlm.nih.gov/pubmed/6100966 PubMed 6324102 http://www.ncbi.nlm.nih.gov/pubmed/6324102 PubMed 6324103 http://www.ncbi.nlm.nih.gov/pubmed/6324103 PubMed 6396164 http://www.ncbi.nlm.nih.gov/pubmed/6396164 PubMed 6397401 http://www.ncbi.nlm.nih.gov/pubmed/6397401 PubMed 8812991 http://www.ncbi.nlm.nih.gov/pubmed/8812991 PubMed 9100006 http://www.ncbi.nlm.nih.gov/pubmed/9100006 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9743633 http://www.ncbi.nlm.nih.gov/pubmed/9743633 RefSeq NP_414773 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414773 RefSeq WP_001291990 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001291990 SMR P0A9M5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9M5 STRING 511145.b0238 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0238&targetmode=cogs STRING COG0503 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0503&targetmode=cogs SUPFAM SSF53271 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53271 SWISS-2DPAGE P0A9M5 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A9M5 UniProtKB XGPT_ECOLI http://www.uniprot.org/uniprot/XGPT_ECOLI UniProtKB-AC P0A9M5 http://www.uniprot.org/uniprot/P0A9M5 charge swissprot:XGPT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:XGPT_ECOLI eggNOG COG0503 http://eggnogapi.embl.de/nog_data/html/tree/COG0503 epestfind swissprot:XGPT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:XGPT_ECOLI garnier swissprot:XGPT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:XGPT_ECOLI helixturnhelix swissprot:XGPT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:XGPT_ECOLI hmoment swissprot:XGPT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:XGPT_ECOLI iep swissprot:XGPT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:XGPT_ECOLI inforesidue swissprot:XGPT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:XGPT_ECOLI octanol swissprot:XGPT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:XGPT_ECOLI pepcoil swissprot:XGPT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:XGPT_ECOLI pepdigest swissprot:XGPT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:XGPT_ECOLI pepinfo swissprot:XGPT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:XGPT_ECOLI pepnet swissprot:XGPT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:XGPT_ECOLI pepstats swissprot:XGPT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:XGPT_ECOLI pepwheel swissprot:XGPT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:XGPT_ECOLI pepwindow swissprot:XGPT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:XGPT_ECOLI sigcleave swissprot:XGPT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:XGPT_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES YIEH_ECOLI Kinetic parameters KM=2.2 mM for 6P-Glu (with magnesium ions as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; KM=2.9 mM for PEP (with manganese ions as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; pH dependence Optimum pH is between 6 and 7.5. {ECO 0000269|PubMed 16990279}; # BioGrid 4263102 8 # COFACTOR YIEH_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 16990279}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 16990279}; Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000269|PubMed 16990279}; Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 16990279}; Note=Magnesium. Can also use other divalent metal cations as manganese, cobalt or zinc. {ECO 0000269|PubMed 16990279}; # EcoGene EG11725 yieH # FUNCTION YIEH_ECOLI Catalyzes strongly the dephosphorylation of 6- phosphogluconate (6P-Glu) and slightly the dephosphorylation of dihydroxyacetone phosphate (DHAP) and phosphoenolpyruvate (PEP). Also hydrolyzes both purines (GMP and IMP) and pyrimidines as secondary substrates. {ECO 0000269|PubMed 15808744, ECO 0000269|PubMed 16990279}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0000287 magnesium ion binding; IDA:UniProtKB. # GO_function GO:0016791 phosphatase activity; IDA:UniProtKB. # GO_function GO:0030145 manganese ion binding; IDA:UniProtKB. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0043167 ion binding # Gene3D 1.10.150.240 -; 1. # Gene3D 3.40.50.1000 -; 2. # InterPro IPR006439 HAD-SF_hydro_IA # InterPro IPR023198 PGP_dom2 # InterPro IPR023214 HAD-like_dom # Organism YIEH_ECOLI Escherichia coli (strain K12) # PATRIC 32122925 VBIEscCol129921_3838 # PIR D65174 D65174 # PRINTS PR00413 HADHALOGNASE # Pfam PF13419 HAD_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIEH_ECOLI 6-phosphogluconate phosphatase # RefSeq NP_418171 NC_000913.3 # RefSeq WP_000086486 NZ_LN832404.1 # SIMILARITY Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. {ECO 0000305}. # SUPFAM SSF56784 SSF56784 # TIGRFAMs TIGR01509 HAD-SF-IA-v3 # eggNOG COG0637 LUCA # eggNOG ENOG4107UB3 Bacteria BLAST swissprot:YIEH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIEH_ECOLI BioCyc ECOL316407:JW3693-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3693-MONOMER BioCyc EcoCyc:EG11725-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11725-MONOMER BioCyc MetaCyc:EG11725-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11725-MONOMER DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1016/j.fmrre.2004.12.006 http://dx.doi.org/10.1016/j.fmrre.2004.12.006 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M605449200 http://dx.doi.org/10.1074/jbc.M605449200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.3.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.3.- http://enzyme.expasy.org/EC/3.1.3.- EchoBASE EB1676 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1676 EcoGene EG11725 http://www.ecogene.org/geneInfo.php?eg_id=EG11725 EnsemblBacteria AAC76738 http://www.ensemblgenomes.org/id/AAC76738 EnsemblBacteria AAC76738 http://www.ensemblgenomes.org/id/AAC76738 EnsemblBacteria BAE77573 http://www.ensemblgenomes.org/id/BAE77573 EnsemblBacteria BAE77573 http://www.ensemblgenomes.org/id/BAE77573 EnsemblBacteria BAE77573 http://www.ensemblgenomes.org/id/BAE77573 EnsemblBacteria b3715 http://www.ensemblgenomes.org/id/b3715 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 1.10.150.240 http://www.cathdb.info/version/latest/superfamily/1.10.150.240 Gene3D 3.40.50.1000 http://www.cathdb.info/version/latest/superfamily/3.40.50.1000 GeneID 948232 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948232 HOGENOM HOG000248341 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000248341&db=HOGENOM6 InParanoid P31467 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31467 IntEnz 3.1.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3 InterPro IPR006439 http://www.ebi.ac.uk/interpro/entry/IPR006439 InterPro IPR023198 http://www.ebi.ac.uk/interpro/entry/IPR023198 InterPro IPR023214 http://www.ebi.ac.uk/interpro/entry/IPR023214 KEGG_Gene ecj:JW3693 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3693 KEGG_Gene eco:b3715 http://www.genome.jp/dbget-bin/www_bget?eco:b3715 OMA RAYVAMF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RAYVAMF PRINTS PR00413 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00413 PSORT swissprot:YIEH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIEH_ECOLI PSORT-B swissprot:YIEH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIEH_ECOLI PSORT2 swissprot:YIEH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIEH_ECOLI Pfam PF13419 http://pfam.xfam.org/family/PF13419 Phobius swissprot:YIEH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIEH_ECOLI PhylomeDB P31467 http://phylomedb.org/?seqid=P31467 ProteinModelPortal P31467 http://www.proteinmodelportal.org/query/uniprot/P31467 PubMed 15808744 http://www.ncbi.nlm.nih.gov/pubmed/15808744 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16990279 http://www.ncbi.nlm.nih.gov/pubmed/16990279 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418171 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418171 RefSeq WP_000086486 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000086486 SMR P31467 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31467 STRING 511145.b3715 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3715&targetmode=cogs SUPFAM SSF56784 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784 TIGRFAMs TIGR01509 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01509 UniProtKB YIEH_ECOLI http://www.uniprot.org/uniprot/YIEH_ECOLI UniProtKB-AC P31467 http://www.uniprot.org/uniprot/P31467 charge swissprot:YIEH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIEH_ECOLI eggNOG COG0637 http://eggnogapi.embl.de/nog_data/html/tree/COG0637 eggNOG ENOG4107UB3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107UB3 epestfind swissprot:YIEH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIEH_ECOLI garnier swissprot:YIEH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIEH_ECOLI helixturnhelix swissprot:YIEH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIEH_ECOLI hmoment swissprot:YIEH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIEH_ECOLI iep swissprot:YIEH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIEH_ECOLI inforesidue swissprot:YIEH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIEH_ECOLI octanol swissprot:YIEH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIEH_ECOLI pepcoil swissprot:YIEH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIEH_ECOLI pepdigest swissprot:YIEH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIEH_ECOLI pepinfo swissprot:YIEH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIEH_ECOLI pepnet swissprot:YIEH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIEH_ECOLI pepstats swissprot:YIEH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIEH_ECOLI pepwheel swissprot:YIEH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIEH_ECOLI pepwindow swissprot:YIEH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIEH_ECOLI sigcleave swissprot:YIEH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIEH_ECOLI ## Database ID URL or Descriptions # AltName PBPA_ECOLI DD-transpeptidase # AltName PBPA_ECOLI Peptidoglycan TGase # AltName PBPA_ECOLI Peptidoglycan TGase # BioGrid 4262992 294 # CAZy GT51 Glycosyltransferase Family 51 # DrugBank DB00274 Cefmetazole # DrugBank DB00303 Ertapenem # DrugBank DB00430 Cefpiramide # DrugBank DB00438 Ceftazidime # DrugBank DB01327 Cefazolin # DrugBank DB01328 Cefonicid # DrugBank DB01329 Cefoperazone # DrugBank DB01331 Cefoxitin # DrugBank DB01332 Ceftizoxime # DrugBank DB01333 Cefradine # DrugBank DB01414 Cefacetrile # DrugBank DB01415 Ceftibuten # DrugBank DB01598 Imipenem # DrugBank DB04570 Latamoxef # DrugBank DB06211 Doripenem # EcoGene EG10748 mrcA # FUNCTION PBPA_ECOLI Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits). # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoliWiki. # GO_function GO:0008658 penicillin binding; IDA:EcoCyc. # GO_function GO:0008955 peptidoglycan glycosyltransferase activity; IDA:EcoCyc. # GO_function GO:0009002 serine-type D-Ala-D-Ala carboxypeptidase activity; IDA:EcoCyc. # GO_process GO:0006508 proteolysis; IDA:EcoCyc. # GO_process GO:0008360 regulation of cell shape; IGI:EcoCyc. # GO_process GO:0009252 peptidoglycan biosynthetic process; IDA:EcoCyc. # GO_process GO:0046677 response to antibiotic; IDA:EcoCyc. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 3.40.710.10 -; 3. # INTERACTION PBPA_ECOLI P45464 lpoA; NbExp=4; IntAct=EBI-1126191, EBI-557795; # IntAct P02918 8 # InterPro IPR001264 Glyco_trans_51 # InterPro IPR001460 PCN-bd_Tpept # InterPro IPR012338 Beta-lactam/transpept-like # InterPro IPR023346 Lysozyme-like_dom # InterPro IPR031376 PCB_OB # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01003 Glycosyltransferases # KEGG_Pathway ko00550 Peptidoglycan biosynthesis # Organism PBPA_ECOLI Escherichia coli (strain K12) # PATHWAY PBPA_ECOLI Cell wall biogenesis; peptidoglycan biosynthesis. # PATRIC 32122224 VBIEscCol129921_3489 # PIR G65134 ZPECPA # Pfam PF00905 Transpeptidase # Pfam PF00912 Transgly # Pfam PF17092 PCB_OB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PBPA_ECOLI Penicillin-binding protein 1A # RecName PBPA_ECOLI Penicillin-insensitive transglycosylase # RecName PBPA_ECOLI Penicillin-sensitive transpeptidase # RefSeq NP_417855 NC_000913.3 # RefSeq WP_001336003 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA58193.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY In the C-terminal section; belongs to the transpeptidase family. {ECO 0000305}. # SIMILARITY In the N-terminal section; belongs to the glycosyltransferase 51 family. {ECO 0000305}. # SUBCELLULAR LOCATION PBPA_ECOLI Cell inner membrane {ECO 0000250}; Single- pass type II membrane protein {ECO 0000250}. # SUPFAM SSF53955 SSF53955 # SUPFAM SSF56601 SSF56601; 4 # eggNOG COG5009 LUCA # eggNOG ENOG4108JQC Bacteria BLAST swissprot:PBPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PBPA_ECOLI BioCyc ECOL316407:JW3359-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3359-MONOMER BioCyc EcoCyc:EG10748-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10748-MONOMER BioCyc MetaCyc:EG10748-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10748-MONOMER COG CAZy: http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=CAZy: COG COG0744 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0744 COG GT51 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=GT51 DIP DIP-10251N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10251N DOI 10.1016/S0006-291X(80)80166-5 http://dx.doi.org/10.1016/S0006-291X(80)80166-5 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.82.7.1999 http://dx.doi.org/10.1073/pnas.82.7.1999 DOI 10.1111/j.1432-1033.1985.tb08768.x http://dx.doi.org/10.1111/j.1432-1033.1985.tb08768.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB00274 http://www.drugbank.ca/drugs/DB00274 DrugBank DB00303 http://www.drugbank.ca/drugs/DB00303 DrugBank DB00430 http://www.drugbank.ca/drugs/DB00430 DrugBank DB00438 http://www.drugbank.ca/drugs/DB00438 DrugBank DB01327 http://www.drugbank.ca/drugs/DB01327 DrugBank DB01328 http://www.drugbank.ca/drugs/DB01328 DrugBank DB01329 http://www.drugbank.ca/drugs/DB01329 DrugBank DB01331 http://www.drugbank.ca/drugs/DB01331 DrugBank DB01332 http://www.drugbank.ca/drugs/DB01332 DrugBank DB01333 http://www.drugbank.ca/drugs/DB01333 DrugBank DB01414 http://www.drugbank.ca/drugs/DB01414 DrugBank DB01415 http://www.drugbank.ca/drugs/DB01415 DrugBank DB01598 http://www.drugbank.ca/drugs/DB01598 DrugBank DB04570 http://www.drugbank.ca/drugs/DB04570 DrugBank DB06211 http://www.drugbank.ca/drugs/DB06211 EC_number EC:2.4.2.- http://www.genome.jp/dbget-bin/www_bget?EC:2.4.2.- EC_number EC:3.4.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.4.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X02164 http://www.ebi.ac.uk/ena/data/view/X02164 ENZYME 2.4.2.- http://enzyme.expasy.org/EC/2.4.2.- ENZYME 3.4.-.- http://enzyme.expasy.org/EC/3.4.-.- EchoBASE EB0741 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0741 EcoGene EG10748 http://www.ecogene.org/geneInfo.php?eg_id=EG10748 EnsemblBacteria AAC76421 http://www.ensemblgenomes.org/id/AAC76421 EnsemblBacteria AAC76421 http://www.ensemblgenomes.org/id/AAC76421 EnsemblBacteria BAE77895 http://www.ensemblgenomes.org/id/BAE77895 EnsemblBacteria BAE77895 http://www.ensemblgenomes.org/id/BAE77895 EnsemblBacteria BAE77895 http://www.ensemblgenomes.org/id/BAE77895 EnsemblBacteria b3396 http://www.ensemblgenomes.org/id/b3396 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0008658 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008658 GO_function GO:0008955 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008955 GO_function GO:0009002 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009002 GO_process GO:0006508 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006508 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0009252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009252 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 3.40.710.10 http://www.cathdb.info/version/latest/superfamily/3.40.710.10 GeneID 947907 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947907 HOGENOM HOG000041138 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000041138&db=HOGENOM6 InParanoid P02918 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P02918 IntAct P02918 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P02918* IntEnz 2.4.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.2 IntEnz 3.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4 InterPro IPR001264 http://www.ebi.ac.uk/interpro/entry/IPR001264 InterPro IPR001460 http://www.ebi.ac.uk/interpro/entry/IPR001460 InterPro IPR012338 http://www.ebi.ac.uk/interpro/entry/IPR012338 InterPro IPR023346 http://www.ebi.ac.uk/interpro/entry/IPR023346 InterPro IPR031376 http://www.ebi.ac.uk/interpro/entry/IPR031376 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01003 http://www.genome.jp/dbget-bin/www_bget?ko01003 KEGG_Gene ecj:JW3359 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3359 KEGG_Gene eco:b3396 http://www.genome.jp/dbget-bin/www_bget?eco:b3396 KEGG_Orthology KO:K05366 http://www.genome.jp/dbget-bin/www_bget?KO:K05366 KEGG_Pathway ko00550 http://www.genome.jp/kegg-bin/show_pathway?ko00550 OMA IAQVWVT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IAQVWVT PSORT swissprot:PBPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PBPA_ECOLI PSORT-B swissprot:PBPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PBPA_ECOLI PSORT2 swissprot:PBPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PBPA_ECOLI Pfam PF00905 http://pfam.xfam.org/family/PF00905 Pfam PF00912 http://pfam.xfam.org/family/PF00912 Pfam PF17092 http://pfam.xfam.org/family/PF17092 Phobius swissprot:PBPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PBPA_ECOLI PhylomeDB P02918 http://phylomedb.org/?seqid=P02918 ProteinModelPortal P02918 http://www.proteinmodelportal.org/query/uniprot/P02918 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3882429 http://www.ncbi.nlm.nih.gov/pubmed/3882429 PubMed 3920658 http://www.ncbi.nlm.nih.gov/pubmed/3920658 PubMed 7006606 http://www.ncbi.nlm.nih.gov/pubmed/7006606 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9841666 http://www.ncbi.nlm.nih.gov/pubmed/9841666 RefSeq NP_417855 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417855 RefSeq WP_001336003 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001336003 STRING 511145.b3396 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3396&targetmode=cogs STRING CAZy: http://string-db.org/newstring_cgi/show_network_section.pl?identifier=CAZy:&targetmode=cogs STRING COG0744 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0744&targetmode=cogs STRING GT51 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=GT51&targetmode=cogs SUPFAM SSF53955 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53955 SUPFAM SSF56601 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56601 UniProtKB PBPA_ECOLI http://www.uniprot.org/uniprot/PBPA_ECOLI UniProtKB-AC P02918 http://www.uniprot.org/uniprot/P02918 charge swissprot:PBPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PBPA_ECOLI eggNOG COG5009 http://eggnogapi.embl.de/nog_data/html/tree/COG5009 eggNOG ENOG4108JQC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108JQC epestfind swissprot:PBPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PBPA_ECOLI garnier swissprot:PBPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PBPA_ECOLI helixturnhelix swissprot:PBPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PBPA_ECOLI hmoment swissprot:PBPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PBPA_ECOLI iep swissprot:PBPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PBPA_ECOLI inforesidue swissprot:PBPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PBPA_ECOLI octanol swissprot:PBPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PBPA_ECOLI pepcoil swissprot:PBPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PBPA_ECOLI pepdigest swissprot:PBPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PBPA_ECOLI pepinfo swissprot:PBPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PBPA_ECOLI pepnet swissprot:PBPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PBPA_ECOLI pepstats swissprot:PBPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PBPA_ECOLI pepwheel swissprot:PBPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PBPA_ECOLI pepwindow swissprot:PBPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PBPA_ECOLI sigcleave swissprot:PBPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PBPA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259423 23 # EcoGene EG12793 yhbX # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0008484 sulfuric ester hydrolase activity; IEA:InterPro. # GO_function GO:0016776 phosphotransferase activity, phosphate group as acceptor; IBA:GO_Central. # GO_process GO:0009244 lipopolysaccharide core region biosynthetic process; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.720.10 -; 1. # InterPro IPR000917 Sulfatase_N # InterPro IPR017849 Alkaline_Pase-like_a/b/a # InterPro IPR017850 Alkaline_phosphatase_core # Organism YHBX_ECOLI Escherichia coli (strain K12) # PATRIC 32121764 VBIEscCol129921_3267 # PIR H65107 H65107 # Pfam PF00884 Sulfatase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHBX_ECOLI Putative phosphoethanolamine transferase YhbX # RefSeq NP_417641 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA57975.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the phosphoethanolamine transferase family. {ECO 0000305}. # SUBCELLULAR LOCATION YHBX_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF53649 SSF53649 # eggNOG COG2194 LUCA # eggNOG ENOG4105DIJ Bacteria BLAST swissprot:YHBX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHBX_ECOLI BioCyc ECOL316407:JW5534-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5534-MONOMER BioCyc EcoCyc:G7655-MONOMER http://biocyc.org/getid?id=EcoCyc:G7655-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.-.- http://www.genome.jp/dbget-bin/www_bget?EC:2.7.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 2.7.-.- http://enzyme.expasy.org/EC/2.7.-.- EchoBASE EB2645 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2645 EcoGene EG12793 http://www.ecogene.org/geneInfo.php?eg_id=EG12793 EnsemblBacteria AAC76206 http://www.ensemblgenomes.org/id/AAC76206 EnsemblBacteria AAC76206 http://www.ensemblgenomes.org/id/AAC76206 EnsemblBacteria BAE77218 http://www.ensemblgenomes.org/id/BAE77218 EnsemblBacteria BAE77218 http://www.ensemblgenomes.org/id/BAE77218 EnsemblBacteria BAE77218 http://www.ensemblgenomes.org/id/BAE77218 EnsemblBacteria b3173 http://www.ensemblgenomes.org/id/b3173 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008484 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008484 GO_function GO:0016776 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016776 GO_process GO:0009244 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009244 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.720.10 http://www.cathdb.info/version/latest/superfamily/3.40.720.10 GeneID 947711 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947711 HOGENOM HOG000125218 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125218&db=HOGENOM6 IntEnz 2.7 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7 InterPro IPR000917 http://www.ebi.ac.uk/interpro/entry/IPR000917 InterPro IPR017849 http://www.ebi.ac.uk/interpro/entry/IPR017849 InterPro IPR017850 http://www.ebi.ac.uk/interpro/entry/IPR017850 KEGG_Gene ecj:JW5534 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5534 KEGG_Gene eco:b3173 http://www.genome.jp/dbget-bin/www_bget?eco:b3173 OMA YSPYLCA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YSPYLCA PSORT swissprot:YHBX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHBX_ECOLI PSORT-B swissprot:YHBX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHBX_ECOLI PSORT2 swissprot:YHBX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHBX_ECOLI Pfam PF00884 http://pfam.xfam.org/family/PF00884 Phobius swissprot:YHBX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHBX_ECOLI PhylomeDB P42640 http://phylomedb.org/?seqid=P42640 ProteinModelPortal P42640 http://www.proteinmodelportal.org/query/uniprot/P42640 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417641 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417641 SMR P42640 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P42640 STRING 511145.b3173 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3173&targetmode=cogs SUPFAM SSF53649 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53649 UniProtKB YHBX_ECOLI http://www.uniprot.org/uniprot/YHBX_ECOLI UniProtKB-AC P42640 http://www.uniprot.org/uniprot/P42640 charge swissprot:YHBX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHBX_ECOLI eggNOG COG2194 http://eggnogapi.embl.de/nog_data/html/tree/COG2194 eggNOG ENOG4105DIJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DIJ epestfind swissprot:YHBX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHBX_ECOLI garnier swissprot:YHBX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHBX_ECOLI helixturnhelix swissprot:YHBX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHBX_ECOLI hmoment swissprot:YHBX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHBX_ECOLI iep swissprot:YHBX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHBX_ECOLI inforesidue swissprot:YHBX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHBX_ECOLI octanol swissprot:YHBX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHBX_ECOLI pepcoil swissprot:YHBX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHBX_ECOLI pepdigest swissprot:YHBX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHBX_ECOLI pepinfo swissprot:YHBX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHBX_ECOLI pepnet swissprot:YHBX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHBX_ECOLI pepstats swissprot:YHBX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHBX_ECOLI pepwheel swissprot:YHBX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHBX_ECOLI pepwindow swissprot:YHBX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHBX_ECOLI sigcleave swissprot:YHBX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHBX_ECOLI ## Database ID URL or Descriptions # ALTERNATIVE PRODUCTS DPO3X_ECOLI Event=Ribosomal frameshifting; Named isoforms=2; Comment=The production of the two protein products from this region is due to programmed ribosomal frameshifting. Frameshifting is about 40% efficient. {ECO 0000269|PubMed 2181440, ECO 0000269|PubMed 2186364, ECO 0000269|PubMed 2187190}; Name=tau; IsoId=P06710-1; Sequence=Displayed; Note=Produced by full-length translation of the dnaX gene.; Name=gamma; IsoId=P06710-2; Sequence=VSP_042848, VSP_042849; Note=Formed by programmed ribosomal frameshifting to a premature stop codon in the -1 frame at codon 430, the last residue is thus Glu and not Ser.; # AltName DPO3X_ECOLI DNA polymerase III subunit gamma # BioGrid 4259846 114 # CATALYTIC ACTIVITY DPO3X_ECOLI Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). # EcoGene EG10245 dnaX # FUNCTION DPO3X_ECOLI DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. # FUNCTION DPO3X_ECOLI Isoform gamma seems to interact with the delta subunit. to transfer the beta subunit on the DNA. # FUNCTION DPO3X_ECOLI Isoform tau serves as a scaffold to help in the dimerization of the core complex. # GO_component GO:0043846 DNA polymerase III, clamp loader complex; IDA:EcoliWiki. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_function GO:0003887 DNA-directed DNA polymerase activity; IEA:UniProtKB-KW. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016887 ATPase activity; IDA:EcoliWiki. # GO_function GO:0017111 nucleoside-triphosphatase activity; IDA:EcoliWiki. # GO_function GO:0030337 DNA polymerase processivity factor activity; IDA:EcoliWiki. # GO_function GO:0042802 identical protein binding; IPI:IntAct. # GO_process GO:0006260 DNA replication; IMP:EcoliWiki. # GO_process GO:0006261 DNA-dependent DNA replication; IBA:GO_Central. # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0030234 enzyme regulator activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.300 -; 1. # INTERACTION DPO3X_ECOLI Self; NbExp=5; IntAct=EBI-549140, EBI-549140; P11989 bglG; NbExp=3; IntAct=EBI-549140, EBI-545674; P0ACB0 dnaB; NbExp=2; IntAct=EBI-549140, EBI-548978; P10443 dnaE; NbExp=10; IntAct=EBI-549140, EBI-549111; P0A988 dnaN; NbExp=4; IntAct=EBI-549140, EBI-542385; P03007 dnaQ; NbExp=4; IntAct=EBI-549140, EBI-549131; P20605 fic; NbExp=2; IntAct=EBI-549140, EBI-1132602; P28630 holA; NbExp=6; IntAct=EBI-2604194, EBI-549153; P28631 holB; NbExp=17; IntAct=EBI-549140, EBI-549161; P28905 holC; NbExp=13; IntAct=EBI-549140, EBI-549169; P28632 holD; NbExp=18; IntAct=EBI-549140, EBI-549176; P23367 mutL; NbExp=2; IntAct=EBI-2604194, EBI-554913; P0AGE0 ssb; NbExp=2; IntAct=EBI-549140, EBI-1118620; # IntAct P06710 33 # InterPro IPR001270 ClpA/B # InterPro IPR003593 AAA+_ATPase # InterPro IPR008921 DNA_pol3_clamp-load_cplx_C # InterPro IPR012763 DNA_pol_III_sug/sutau # InterPro IPR021029 DNA_pol_III_tau_dom-5 # InterPro IPR022001 DNA_pol3_tau_IV # InterPro IPR022754 DNA_pol_III_gamma-3 # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03032 DNA replication proteins # KEGG_Brite ko03032 M00260 DNA polymerase III complex, bacteria # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Brite ko03400 M00260 DNA polymerase III complex, bacteria # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00240 Pyrimidine metabolism # KEGG_Pathway ko03030 DNA replication # KEGG_Pathway ko03430 Mismatch repair # KEGG_Pathway ko03440 Homologous recombination # Organism DPO3X_ECOLI Escherichia coli (strain K12) # PATRIC 32116097 VBIEscCol129921_0490 # PDB 1JR3 X-ray; 2.70 A; A/B/C=1-373 # PDB 1NJF X-ray; 2.30 A; A/B/C/D=1-243 # PDB 1NJG X-ray; 2.20 A; A/B=1-243 # PDB 1XXH X-ray; 3.45 A; B/C/D/G/H/I=1-373 # PDB 1XXI X-ray; 4.10 A; B/C/D/G/H/I=1-368 # PDB 2AYA NMR; -; A=499-625 # PDB 3GLF X-ray; 3.39 A; B/C/D/G/H/I=1-373 # PDB 3GLG X-ray; 3.25 A; B/C/D/G/H/I=1-373 # PDB 3GLH X-ray; 3.89 A; B/C/D/G/H/I/L/M/N=1-373 # PDB 3GLI X-ray; 3.50 A; B/C/D/G/H/I=1-373 # PDB 5FKU EM; 8.34 A; E=500-643 # PDB 5FKV EM; 8.00 A; E=500-643 # PIR A25549 DJEC3G # PRINTS PR00300 CLPPROTEASEA # Pfam PF12168 DNA_pol3_tau_4 # Pfam PF12169 DNA_pol3_gamma3 # Pfam PF12170 DNA_pol3_tau_5 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DPO3X_ECOLI DNA polymerase III subunit tau # RefSeq NP_415003 NC_000913.3 # RefSeq WP_000122013 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA28175.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the DnaX/STICHEL family. {ECO 0000305}. # SMART SM00382 AAA # SUBUNIT The DNA polymerase holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential subassemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core (subunits alpha, epsilon and theta) contains the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork. This complex contains delta, delta', psi and chi, and copies of either or both of two different DnaX proteins, isoform gamma and tau. The composition of the holoenzyme is, therefore (alpha,epsilon,theta)[2]-(isoform:gamma/tau)[3]-delta,delta', psi,chi-beta[4]. # SUPFAM SSF48019 SSF48019 # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR02397 dnaX_nterm # eggNOG COG2812 LUCA # eggNOG ENOG4107QMP Bacteria BLAST swissprot:DPO3X_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DPO3X_ECOLI BioCyc ECOL316407:JW0459-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0459-MONOMER BioCyc EcoCyc:EG10245-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10245-MONOMER BioCyc EcoCyc:MONOMER0-2383 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2383 BioCyc MetaCyc:EG10245-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10245-MONOMER BioCyc MetaCyc:MONOMER0-2383 http://biocyc.org/getid?id=MetaCyc:MONOMER0-2383 COG COG2812 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2812 DIP DIP-9464N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9464N DOI 10.1002/bies.950140206 http://dx.doi.org/10.1002/bies.950140206 DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.87.10.3713 http://dx.doi.org/10.1073/pnas.87.10.3713 DOI 10.1073/pnas.87.7.2516 http://dx.doi.org/10.1073/pnas.87.7.2516 DOI 10.1093/nar/14.16.6541 http://dx.doi.org/10.1093/nar/14.16.6541 DOI 10.1093/nar/14.20.8091 http://dx.doi.org/10.1093/nar/14.20.8091 DOI 10.1093/nar/18.7.1725 http://dx.doi.org/10.1093/nar/18.7.1725 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.7.7 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.7 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M38777 http://www.ebi.ac.uk/ena/data/view/M38777 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL X04275 http://www.ebi.ac.uk/ena/data/view/X04275 EMBL X04487 http://www.ebi.ac.uk/ena/data/view/X04487 EMBL X04487 http://www.ebi.ac.uk/ena/data/view/X04487 ENZYME 2.7.7.7 http://enzyme.expasy.org/EC/2.7.7.7 EchoBASE EB0241 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0241 EcoGene EG10245 http://www.ecogene.org/geneInfo.php?eg_id=EG10245 EnsemblBacteria AAC73572 http://www.ensemblgenomes.org/id/AAC73572 EnsemblBacteria AAC73572 http://www.ensemblgenomes.org/id/AAC73572 EnsemblBacteria BAE76249 http://www.ensemblgenomes.org/id/BAE76249 EnsemblBacteria BAE76249 http://www.ensemblgenomes.org/id/BAE76249 EnsemblBacteria BAE76249 http://www.ensemblgenomes.org/id/BAE76249 EnsemblBacteria b0470 http://www.ensemblgenomes.org/id/b0470 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0043846 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043846 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003887 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_function GO:0017111 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017111 GO_function GO:0030337 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030337 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0006260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260 GO_process GO:0006261 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006261 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945105 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945105 HOGENOM HOG000083934 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000083934&db=HOGENOM6 InParanoid P06710 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P06710 IntAct P06710 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P06710* IntEnz 2.7.7.7 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.7 InterPro IPR001270 http://www.ebi.ac.uk/interpro/entry/IPR001270 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR008921 http://www.ebi.ac.uk/interpro/entry/IPR008921 InterPro IPR012763 http://www.ebi.ac.uk/interpro/entry/IPR012763 InterPro IPR021029 http://www.ebi.ac.uk/interpro/entry/IPR021029 InterPro IPR022001 http://www.ebi.ac.uk/interpro/entry/IPR022001 InterPro IPR022754 http://www.ebi.ac.uk/interpro/entry/IPR022754 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03032 http://www.genome.jp/dbget-bin/www_bget?ko03032 KEGG_Brite ko03032 http://www.genome.jp/dbget-bin/www_bget?ko03032 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW0459 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0459 KEGG_Gene eco:b0470 http://www.genome.jp/dbget-bin/www_bget?eco:b0470 KEGG_Orthology KO:K02343 http://www.genome.jp/dbget-bin/www_bget?KO:K02343 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Pathway ko03030 http://www.genome.jp/kegg-bin/show_pathway?ko03030 KEGG_Pathway ko03430 http://www.genome.jp/kegg-bin/show_pathway?ko03430 KEGG_Pathway ko03440 http://www.genome.jp/kegg-bin/show_pathway?ko03440 KEGG_Reaction rn:R00375 http://www.genome.jp/dbget-bin/www_bget?rn:R00375 KEGG_Reaction rn:R00376 http://www.genome.jp/dbget-bin/www_bget?rn:R00376 KEGG_Reaction rn:R00377 http://www.genome.jp/dbget-bin/www_bget?rn:R00377 KEGG_Reaction rn:R00378 http://www.genome.jp/dbget-bin/www_bget?rn:R00378 MINT MINT-1222776 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1222776 OMA TALEHEK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TALEHEK PDB 1JR3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1JR3 PDB 1NJF http://www.ebi.ac.uk/pdbe-srv/view/entry/1NJF PDB 1NJG http://www.ebi.ac.uk/pdbe-srv/view/entry/1NJG PDB 1XXH http://www.ebi.ac.uk/pdbe-srv/view/entry/1XXH PDB 1XXI http://www.ebi.ac.uk/pdbe-srv/view/entry/1XXI PDB 2AYA http://www.ebi.ac.uk/pdbe-srv/view/entry/2AYA PDB 3GLF http://www.ebi.ac.uk/pdbe-srv/view/entry/3GLF PDB 3GLG http://www.ebi.ac.uk/pdbe-srv/view/entry/3GLG PDB 3GLH http://www.ebi.ac.uk/pdbe-srv/view/entry/3GLH PDB 3GLI http://www.ebi.ac.uk/pdbe-srv/view/entry/3GLI PDB 5FKU http://www.ebi.ac.uk/pdbe-srv/view/entry/5FKU PDB 5FKV http://www.ebi.ac.uk/pdbe-srv/view/entry/5FKV PDBsum 1JR3 http://www.ebi.ac.uk/pdbsum/1JR3 PDBsum 1NJF http://www.ebi.ac.uk/pdbsum/1NJF PDBsum 1NJG http://www.ebi.ac.uk/pdbsum/1NJG PDBsum 1XXH http://www.ebi.ac.uk/pdbsum/1XXH PDBsum 1XXI http://www.ebi.ac.uk/pdbsum/1XXI PDBsum 2AYA http://www.ebi.ac.uk/pdbsum/2AYA PDBsum 3GLF http://www.ebi.ac.uk/pdbsum/3GLF PDBsum 3GLG http://www.ebi.ac.uk/pdbsum/3GLG PDBsum 3GLH http://www.ebi.ac.uk/pdbsum/3GLH PDBsum 3GLI http://www.ebi.ac.uk/pdbsum/3GLI PDBsum 5FKU http://www.ebi.ac.uk/pdbsum/5FKU PDBsum 5FKV http://www.ebi.ac.uk/pdbsum/5FKV PRINTS PR00300 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00300 PSORT swissprot:DPO3X_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DPO3X_ECOLI PSORT-B swissprot:DPO3X_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DPO3X_ECOLI PSORT2 swissprot:DPO3X_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DPO3X_ECOLI Pfam PF12168 http://pfam.xfam.org/family/PF12168 Pfam PF12169 http://pfam.xfam.org/family/PF12169 Pfam PF12170 http://pfam.xfam.org/family/PF12170 Phobius swissprot:DPO3X_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DPO3X_ECOLI PhylomeDB P06710 http://phylomedb.org/?seqid=P06710 ProteinModelPortal P06710 http://www.proteinmodelportal.org/query/uniprot/P06710 PubMed 1575709 http://www.ncbi.nlm.nih.gov/pubmed/1575709 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2181440 http://www.ncbi.nlm.nih.gov/pubmed/2181440 PubMed 2186364 http://www.ncbi.nlm.nih.gov/pubmed/2186364 PubMed 2187190 http://www.ncbi.nlm.nih.gov/pubmed/2187190 PubMed 3018672 http://www.ncbi.nlm.nih.gov/pubmed/3018672 PubMed 3283125 http://www.ncbi.nlm.nih.gov/pubmed/3283125 PubMed 3534795 http://www.ncbi.nlm.nih.gov/pubmed/3534795 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_415003 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415003 RefSeq WP_000122013 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000122013 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P06710 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P06710 STRING 511145.b0470 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0470&targetmode=cogs STRING COG2812 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2812&targetmode=cogs SUPFAM SSF48019 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48019 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR02397 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02397 UniProtKB DPO3X_ECOLI http://www.uniprot.org/uniprot/DPO3X_ECOLI UniProtKB-AC P06710 http://www.uniprot.org/uniprot/P06710 charge swissprot:DPO3X_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DPO3X_ECOLI eggNOG COG2812 http://eggnogapi.embl.de/nog_data/html/tree/COG2812 eggNOG ENOG4107QMP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QMP epestfind swissprot:DPO3X_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DPO3X_ECOLI garnier swissprot:DPO3X_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DPO3X_ECOLI helixturnhelix swissprot:DPO3X_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DPO3X_ECOLI hmoment swissprot:DPO3X_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DPO3X_ECOLI iep swissprot:DPO3X_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DPO3X_ECOLI inforesidue swissprot:DPO3X_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DPO3X_ECOLI octanol swissprot:DPO3X_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DPO3X_ECOLI pepcoil swissprot:DPO3X_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DPO3X_ECOLI pepdigest swissprot:DPO3X_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DPO3X_ECOLI pepinfo swissprot:DPO3X_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DPO3X_ECOLI pepnet swissprot:DPO3X_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DPO3X_ECOLI pepstats swissprot:DPO3X_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DPO3X_ECOLI pepwheel swissprot:DPO3X_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DPO3X_ECOLI pepwindow swissprot:DPO3X_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DPO3X_ECOLI sigcleave swissprot:DPO3X_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DPO3X_ECOLI ## Database ID URL or Descriptions # AltName GLK_ECOLI Glucose kinase # BioGrid 4260563 6 # CATALYTIC ACTIVITY GLK_ECOLI ATP + D-glucose = ADP + D-glucose 6-phosphate. # EcoGene EG12957 glk # FUNCTION GLK_ECOLI Not highly important in E.coli as glucose is transported into the cell by the PTS system already as glucose 6-phosphate. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004340 glucokinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006096 glycolytic process; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # HAMAP MF_00524 Glucokinase # IntAct P0A6V8 5 # InterPro IPR003836 Glucokinase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00010 Glycolysis / Gluconeogenesis # KEGG_Pathway ko00052 Galactose metabolism # KEGG_Pathway ko00500 Starch and sucrose metabolism # KEGG_Pathway ko00520 Amino sugar and nucleotide sugar metabolism # KEGG_Pathway ko00521 Streptomycin biosynthesis # KEGG_Pathway ko00524 Butirosin and neomycin biosynthesis # Organism GLK_ECOLI Escherichia coli (strain K12) # PATRIC 32120155 VBIEscCol129921_2486 # PIR A65013 A65013 # Pfam PF02685 Glucokinase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLK_ECOLI Glucokinase # RefSeq NP_416889 NC_000913.3 # RefSeq WP_000170346 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial glucokinase family. {ECO 0000305}. # SUBCELLULAR LOCATION GLK_ECOLI Cytoplasm. # TIGRFAMs TIGR00749 glk # eggNOG COG0837 LUCA # eggNOG ENOG4105CHC Bacteria BLAST swissprot:GLK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLK_ECOLI BioCyc ECOL316407:JW2385-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2385-MONOMER BioCyc EcoCyc:GLUCOKIN-MONOMER http://biocyc.org/getid?id=EcoCyc:GLUCOKIN-MONOMER BioCyc MetaCyc:GLUCOKIN-MONOMER http://biocyc.org/getid?id=MetaCyc:GLUCOKIN-MONOMER COG COG0837 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0837 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.2 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U22490 http://www.ebi.ac.uk/ena/data/view/U22490 ENZYME 2.7.1.2 http://enzyme.expasy.org/EC/2.7.1.2 EchoBASE EB2791 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2791 EcoGene EG12957 http://www.ecogene.org/geneInfo.php?eg_id=EG12957 EnsemblBacteria AAC75447 http://www.ensemblgenomes.org/id/AAC75447 EnsemblBacteria AAC75447 http://www.ensemblgenomes.org/id/AAC75447 EnsemblBacteria BAA16258 http://www.ensemblgenomes.org/id/BAA16258 EnsemblBacteria BAA16258 http://www.ensemblgenomes.org/id/BAA16258 EnsemblBacteria BAA16258 http://www.ensemblgenomes.org/id/BAA16258 EnsemblBacteria b2388 http://www.ensemblgenomes.org/id/b2388 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004340 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004340 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006096 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006096 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GeneID 946858 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946858 HAMAP MF_00524 http://hamap.expasy.org/unirule/MF_00524 HOGENOM HOG000274469 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000274469&db=HOGENOM6 InParanoid P0A6V8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6V8 IntAct P0A6V8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6V8* IntEnz 2.7.1.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.2 InterPro IPR003836 http://www.ebi.ac.uk/interpro/entry/IPR003836 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2385 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2385 KEGG_Gene eco:b2388 http://www.genome.jp/dbget-bin/www_bget?eco:b2388 KEGG_Orthology KO:K00845 http://www.genome.jp/dbget-bin/www_bget?KO:K00845 KEGG_Pathway ko00010 http://www.genome.jp/kegg-bin/show_pathway?ko00010 KEGG_Pathway ko00052 http://www.genome.jp/kegg-bin/show_pathway?ko00052 KEGG_Pathway ko00500 http://www.genome.jp/kegg-bin/show_pathway?ko00500 KEGG_Pathway ko00520 http://www.genome.jp/kegg-bin/show_pathway?ko00520 KEGG_Pathway ko00521 http://www.genome.jp/kegg-bin/show_pathway?ko00521 KEGG_Pathway ko00524 http://www.genome.jp/kegg-bin/show_pathway?ko00524 KEGG_Reaction rn:R00299 http://www.genome.jp/dbget-bin/www_bget?rn:R00299 KEGG_Reaction rn:R01600 http://www.genome.jp/dbget-bin/www_bget?rn:R01600 KEGG_Reaction rn:R01786 http://www.genome.jp/dbget-bin/www_bget?rn:R01786 OMA GHADFAP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GHADFAP PSORT swissprot:GLK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLK_ECOLI PSORT-B swissprot:GLK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLK_ECOLI PSORT2 swissprot:GLK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLK_ECOLI Pfam PF02685 http://pfam.xfam.org/family/PF02685 Phobius swissprot:GLK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLK_ECOLI PhylomeDB P0A6V8 http://phylomedb.org/?seqid=P0A6V8 ProteinModelPortal P0A6V8 http://www.proteinmodelportal.org/query/uniprot/P0A6V8 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9023215 http://www.ncbi.nlm.nih.gov/pubmed/9023215 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416889 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416889 RefSeq WP_000170346 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000170346 SMR P0A6V8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6V8 STRING 511145.b2388 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2388&targetmode=cogs STRING COG0837 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0837&targetmode=cogs TIGRFAMs TIGR00749 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00749 UniProtKB GLK_ECOLI http://www.uniprot.org/uniprot/GLK_ECOLI UniProtKB-AC P0A6V8 http://www.uniprot.org/uniprot/P0A6V8 charge swissprot:GLK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLK_ECOLI eggNOG COG0837 http://eggnogapi.embl.de/nog_data/html/tree/COG0837 eggNOG ENOG4105CHC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CHC epestfind swissprot:GLK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLK_ECOLI garnier swissprot:GLK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLK_ECOLI helixturnhelix swissprot:GLK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLK_ECOLI hmoment swissprot:GLK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLK_ECOLI iep swissprot:GLK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLK_ECOLI inforesidue swissprot:GLK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLK_ECOLI octanol swissprot:GLK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLK_ECOLI pepcoil swissprot:GLK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLK_ECOLI pepdigest swissprot:GLK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLK_ECOLI pepinfo swissprot:GLK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLK_ECOLI pepnet swissprot:GLK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLK_ECOLI pepstats swissprot:GLK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLK_ECOLI pepwheel swissprot:GLK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLK_ECOLI pepwindow swissprot:GLK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLK_ECOLI sigcleave swissprot:GLK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLK_ECOLI ## Database ID URL or Descriptions # AltName Isocitrase {ECO 0000303|Ref.9} # AltName Isocitratase {ECO 0000303|Ref.9} # BIOPHYSICOCHEMICAL PROPERTIES ACEA_ECOLI Kinetic parameters KM=0.076 uM for threo-D-isocitrate (at pH 7.3) {ECO 0000269|PubMed 7826335}; KM=8 uM for threo-D-isocitrate (at pH 7.5 and 25 degrees Celsius) {ECO 0000269|Ref.9}; KM=32 uM for isocitrate (at pH 6.8) {ECO 0000269|PubMed 3281659}; KM=63 uM for isocitrate (at pH 7.3) {ECO 0000269|PubMed 3281659}; KM=130 uM for glyoxylate (at pH 7.3) {ECO 0000269|PubMed 3281659}; KM=590 uM for succinate (at pH 7.3) {ECO 0000269|PubMed 3281659}; Note=Kcat is 28.5 sec(-1) for isocitrate lyase activity with threo-D-isocitrate as substrate (at pH 7.3). {ECO 0000269|PubMed 7826335}; pH dependence Optimum pH is 7.3. {ECO 0000269|Ref.9}; # BRENDA 4.1.3 2026 # BioGrid 4263469 6 # CATALYTIC ACTIVITY ACEA_ECOLI Isocitrate = succinate + glyoxylate. {ECO 0000269|PubMed 3281659, ECO 0000269|PubMed 7826335, ECO 0000269|Ref.9}. # COFACTOR ACEA_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 3291954}; Note=Divalent metal cations. Can also use Mn(2+) ion. {ECO 0000269|PubMed 3291954}; # ENZYME REGULATION ACEA_ECOLI Activated by phosphorylation on histidine. Competitively inhibited by 3-phosphosglycerate, oxalate, malate, chloride, phosphate and sulfate ions, and uncompetitively inhibited by succinate and phosphoenolpyruvate (PEP). {ECO 0000269|PubMed 3276689, ECO 0000269|PubMed 3281659, ECO 0000269|PubMed 3291954}. # EcoGene EG10022 aceA # FUNCTION ACEA_ECOLI Involved in the metabolic adaptation in response to environmental changes. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates. {ECO 0000269|PubMed 15748982, ECO 0000269|PubMed 3281659, ECO 0000269|PubMed 3291954, ECO 0000269|PubMed 7826335, ECO 0000269|Ref.9}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0004451 isocitrate lyase activity; IDA:EcoliWiki. # GO_function GO:0043169 cation binding; IDA:EcoliWiki. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer; IBA:GO_Central. # GO_process GO:0006097 glyoxylate cycle; IBA:GO_Central. # GO_process GO:0006099 tricarboxylic acid cycle; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.60 -; 1. # IntAct P0A9G6 3 # InterPro IPR006254 Isocitrate_lyase # InterPro IPR015813 Pyrv/PenolPyrv_Kinase-like_dom # InterPro IPR018523 Isocitrate_lyase_ph_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00630 Glyoxylate and dicarboxylate metabolism # Organism ACEA_ECOLI Escherichia coli (strain K12) # PATHWAY Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2. {ECO 0000305|PubMed:15748982}. # PATRIC 32123557 VBIEscCol129921_4127 # PDB 1IGW X-ray; 2.10 A; A/B/C/D=1-434 # PIR S05692 WZECIC # PROSITE PS00161 ISOCITRATE_LYASE # Pfam PF00463 ICL; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Isocitrate lyase {ECO 0000303|Ref.9} # RefSeq NP_418439 NC_000913.3 # RefSeq WP_000857856 NZ_LN832404.1 # SIMILARITY Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family. {ECO 0000305}. # SUBUNIT ACEA_ECOLI Homotetramer. {ECO 0000269|PubMed 11526312, ECO 0000269|PubMed 3049537, ECO 0000269|PubMed 3281659, ECO 0000269|Ref.9}. # SUPFAM SSF51621 SSF51621 # TIGRFAMs TIGR01346 isocit_lyase; 2 # UniPathway UPA00703 UER00719 # eggNOG COG2224 LUCA # eggNOG ENOG4108I9X Bacteria BLAST swissprot:ACEA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ACEA_ECOLI BioCyc ECOL316407:JW3975-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3975-MONOMER BioCyc EcoCyc:ISOCIT-LYASE-MONOMER http://biocyc.org/getid?id=EcoCyc:ISOCIT-LYASE-MONOMER BioCyc MetaCyc:ISOCIT-LYASE-MONOMER http://biocyc.org/getid?id=MetaCyc:ISOCIT-LYASE-MONOMER COG COG2224 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2224 DIP DIP-35893N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35893N DOI 10.1016/0304-4165(88)90125-0 http://dx.doi.org/10.1016/0304-4165(88)90125-0 DOI 10.1016/j.resmic.2004.09.004 http://dx.doi.org/10.1016/j.resmic.2004.09.004 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2500025 http://dx.doi.org/10.1042/bj2500025 DOI 10.1042/bj3050239 http://dx.doi.org/10.1042/bj3050239 DOI 10.1093/nar/16.12.5689 http://dx.doi.org/10.1093/nar/16.12.5689 DOI 10.1093/nar/16.19.9342 http://dx.doi.org/10.1093/nar/16.19.9342 DOI 10.1093/nar/16.22.10924 http://dx.doi.org/10.1093/nar/16.22.10924 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1107/S0907444901008642 http://dx.doi.org/10.1107/S0907444901008642 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.1.3.1 {ECO:0000269|PubMed:3281659, ECO:0000269|PubMed:7826335, ECO:0000269|Ref.9} http://www.genome.jp/dbget-bin/www_bget?EC:4.1.3.1 {ECO:0000269|PubMed:3281659, ECO:0000269|PubMed:7826335, ECO:0000269|Ref.9} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M20714 http://www.ebi.ac.uk/ena/data/view/M20714 EMBL M22621 http://www.ebi.ac.uk/ena/data/view/M22621 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X07543 http://www.ebi.ac.uk/ena/data/view/X07543 EMBL X12431 http://www.ebi.ac.uk/ena/data/view/X12431 ENZYME 4.1.3.1 {ECO:0000269|PubMed:3281659, ECO:0000269|PubMed:7826335, ECO:0000269|Ref.9} http://enzyme.expasy.org/EC/4.1.3.1 {ECO:0000269|PubMed:3281659, ECO:0000269|PubMed:7826335, ECO:0000269|Ref.9} EchoBASE EB0021 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0021 EcoGene EG10022 http://www.ecogene.org/geneInfo.php?eg_id=EG10022 EnsemblBacteria AAC76985 http://www.ensemblgenomes.org/id/AAC76985 EnsemblBacteria AAC76985 http://www.ensemblgenomes.org/id/AAC76985 EnsemblBacteria BAE78017 http://www.ensemblgenomes.org/id/BAE78017 EnsemblBacteria BAE78017 http://www.ensemblgenomes.org/id/BAE78017 EnsemblBacteria BAE78017 http://www.ensemblgenomes.org/id/BAE78017 EnsemblBacteria b4015 http://www.ensemblgenomes.org/id/b4015 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004451 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004451 GO_function GO:0043169 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043169 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0046912 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046912 GO_process GO:0006097 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006097 GO_process GO:0006099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006099 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.60 http://www.cathdb.info/version/latest/superfamily/3.20.20.60 GeneID 948517 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948517 HOGENOM HOG000238475 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000238475&db=HOGENOM6 InParanoid P0A9G6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9G6 IntAct P0A9G6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9G6* IntEnz 4.1.3.1 {ECO:0000269|PubMed:3281659, ECO:0000269|PubMed:7826335, ECO:0000269|Ref.9} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.3.1 {ECO:0000269|PubMed:3281659, ECO:0000269|PubMed:7826335, ECO:0000269|Ref.9} InterPro IPR006254 http://www.ebi.ac.uk/interpro/entry/IPR006254 InterPro IPR015813 http://www.ebi.ac.uk/interpro/entry/IPR015813 InterPro IPR018523 http://www.ebi.ac.uk/interpro/entry/IPR018523 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3975 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3975 KEGG_Gene eco:b4015 http://www.genome.jp/dbget-bin/www_bget?eco:b4015 KEGG_Orthology KO:K01637 http://www.genome.jp/dbget-bin/www_bget?KO:K01637 KEGG_Pathway ko00630 http://www.genome.jp/kegg-bin/show_pathway?ko00630 KEGG_Reaction rn:R00479 http://www.genome.jp/dbget-bin/www_bget?rn:R00479 OMA LEKDWAE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LEKDWAE PDB 1IGW http://www.ebi.ac.uk/pdbe-srv/view/entry/1IGW PDBsum 1IGW http://www.ebi.ac.uk/pdbsum/1IGW PROSITE PS00161 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00161 PSORT swissprot:ACEA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ACEA_ECOLI PSORT-B swissprot:ACEA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ACEA_ECOLI PSORT2 swissprot:ACEA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ACEA_ECOLI Pfam PF00463 http://pfam.xfam.org/family/PF00463 Phobius swissprot:ACEA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ACEA_ECOLI PhylomeDB P0A9G6 http://phylomedb.org/?seqid=P0A9G6 ProteinModelPortal P0A9G6 http://www.proteinmodelportal.org/query/uniprot/P0A9G6 PubMed 11526312 http://www.ncbi.nlm.nih.gov/pubmed/11526312 PubMed 15748982 http://www.ncbi.nlm.nih.gov/pubmed/15748982 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2836370 http://www.ncbi.nlm.nih.gov/pubmed/2836370 PubMed 3049537 http://www.ncbi.nlm.nih.gov/pubmed/3049537 PubMed 3050899 http://www.ncbi.nlm.nih.gov/pubmed/3050899 PubMed 3060852 http://www.ncbi.nlm.nih.gov/pubmed/3060852 PubMed 3276689 http://www.ncbi.nlm.nih.gov/pubmed/3276689 PubMed 3281659 http://www.ncbi.nlm.nih.gov/pubmed/3281659 PubMed 3290857 http://www.ncbi.nlm.nih.gov/pubmed/3290857 PubMed 3291954 http://www.ncbi.nlm.nih.gov/pubmed/3291954 PubMed 7826335 http://www.ncbi.nlm.nih.gov/pubmed/7826335 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418439 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418439 RefSeq WP_000857856 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000857856 SMR P0A9G6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9G6 STRING 511145.b4015 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4015&targetmode=cogs STRING COG2224 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2224&targetmode=cogs SUPFAM SSF51621 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51621 SWISS-2DPAGE P0A9G6 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A9G6 TIGRFAMs TIGR01346 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01346 UniProtKB ACEA_ECOLI http://www.uniprot.org/uniprot/ACEA_ECOLI UniProtKB-AC P0A9G6 http://www.uniprot.org/uniprot/P0A9G6 charge swissprot:ACEA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ACEA_ECOLI eggNOG COG2224 http://eggnogapi.embl.de/nog_data/html/tree/COG2224 eggNOG ENOG4108I9X http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108I9X epestfind swissprot:ACEA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ACEA_ECOLI garnier swissprot:ACEA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ACEA_ECOLI helixturnhelix swissprot:ACEA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ACEA_ECOLI hmoment swissprot:ACEA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ACEA_ECOLI iep swissprot:ACEA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ACEA_ECOLI inforesidue swissprot:ACEA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ACEA_ECOLI octanol swissprot:ACEA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ACEA_ECOLI pepcoil swissprot:ACEA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ACEA_ECOLI pepdigest swissprot:ACEA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ACEA_ECOLI pepinfo swissprot:ACEA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ACEA_ECOLI pepnet swissprot:ACEA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ACEA_ECOLI pepstats swissprot:ACEA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ACEA_ECOLI pepwheel swissprot:ACEA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ACEA_ECOLI pepwindow swissprot:ACEA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ACEA_ECOLI sigcleave swissprot:ACEA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ACEA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259990 7 # EcoGene EG10417 grxA # FUNCTION GLRX1_ECOLI The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfide bonds in a coupled system with glutathione reductase. # GO_component GO:0005623 cell; IEA:GOC. # GO_function GO:0009055 electron carrier activity; IEA:InterPro. # GO_function GO:0015035 protein disulfide oxidoreductase activity; IEA:InterPro. # GO_process GO:0009263 deoxyribonucleotide biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0045454 cell redox homeostasis; IEA:InterPro. # GOslim_component GO:0005623 cell # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0042592 homeostatic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.30.10 -; 1. # IntAct P68688 16 # InterPro IPR002109 Glutaredoxin # InterPro IPR011767 GLR_AS # InterPro IPR011902 GRXA # InterPro IPR012336 Thioredoxin-like_fold # InterPro IPR014025 Glutaredoxin_subgr # KEGG_Brite ko03110 Chaperones and folding catalysts # Organism GLRX1_ECOLI Escherichia coli (strain K12) # PATRIC 32116903 VBIEscCol129921_0877 # PDB 1EGO NMR; -; A=1-85 # PDB 1EGR NMR; -; A=1-85 # PDB 1GRX NMR; -; A=1-85 # PDB 1QFN NMR; -; A=1-85 # PDB 1UPY Model; -; G=1-85 # PDB 1UPZ Model; -; G=1-85 # PDB 1UQ0 Model; -; G=1-85 # PDB 1UQ1 Model; -; G=1-85 # PDB 1UQ2 Model; -; G=1-85 # PDB 1UQ3 Model; -; G=1-85 # PDB 1UQ6 Model; -; G=1-85 # PDB 1UQ7 Model; -; G=1-85 # PDB 1UQH Model; -; G=1-85 # PDB 1UQN Model; -; G=1-85 # PIR A00283 GDEC # PRINTS PR00160 GLUTAREDOXIN # PROSITE PS00195 GLUTAREDOXIN_1 # PROSITE PS51354 GLUTAREDOXIN_2 # Pfam PF00462 Glutaredoxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLRX1_ECOLI Glutaredoxin-1 # RefSeq NP_415370 NC_000913.3 # RefSeq WP_001195240 NZ_LN832404.1 # SIMILARITY Belongs to the glutaredoxin family. {ECO 0000305}. # SIMILARITY Contains 1 glutaredoxin domain. {ECO:0000255|PROSITE- ProRule PRU00686}. # SUBUNIT GLRX1_ECOLI Monomer. # SUPFAM SSF52833 SSF52833 # TIGRFAMs TIGR02183 GRXA # eggNOG COG0695 LUCA # eggNOG ENOG41090BQ Bacteria BLAST swissprot:GLRX1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLRX1_ECOLI BioCyc ECOL316407:JW0833-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0833-MONOMER BioCyc EcoCyc:RED-GLUTAREDOXIN http://biocyc.org/getid?id=EcoCyc:RED-GLUTAREDOXIN BioCyc MetaCyc:RED-GLUTAREDOXIN http://biocyc.org/getid?id=MetaCyc:RED-GLUTAREDOXIN COG COG0695 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0695 DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/pro.5560010302 http://dx.doi.org/10.1002/pro.5560010302 DOI 10.1016/0022-2836(91)90935-Y http://dx.doi.org/10.1016/0022-2836(91)90935-Y DOI 10.1016/0378-1119(86)90003-X http://dx.doi.org/10.1016/0378-1119(86)90003-X DOI 10.1021/bi962181g http://dx.doi.org/10.1021/bi962181g DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1432-1033.1983.tb07730.x http://dx.doi.org/10.1111/j.1432-1033.1983.tb07730.x DOI 10.1111/j.1432-1033.1991.tb16194.x http://dx.doi.org/10.1111/j.1432-1033.1991.tb16194.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M13449 http://www.ebi.ac.uk/ena/data/view/M13449 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18655 http://www.ebi.ac.uk/ena/data/view/U18655 EchoBASE EB0412 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0412 EcoGene EG10417 http://www.ecogene.org/geneInfo.php?eg_id=EG10417 EnsemblBacteria AAC73936 http://www.ensemblgenomes.org/id/AAC73936 EnsemblBacteria AAC73936 http://www.ensemblgenomes.org/id/AAC73936 EnsemblBacteria BAA35552 http://www.ensemblgenomes.org/id/BAA35552 EnsemblBacteria BAA35552 http://www.ensemblgenomes.org/id/BAA35552 EnsemblBacteria BAA35552 http://www.ensemblgenomes.org/id/BAA35552 EnsemblBacteria b0849 http://www.ensemblgenomes.org/id/b0849 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005623 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005623 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0015035 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015035 GO_process GO:0009263 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009263 GO_process GO:0045454 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045454 GOslim_component GO:0005623 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005623 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.30.10 http://www.cathdb.info/version/latest/superfamily/3.40.30.10 GeneID 945479 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945479 HOGENOM HOG000095203 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000095203&db=HOGENOM6 InParanoid P68688 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P68688 IntAct P68688 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P68688* InterPro IPR002109 http://www.ebi.ac.uk/interpro/entry/IPR002109 InterPro IPR011767 http://www.ebi.ac.uk/interpro/entry/IPR011767 InterPro IPR011902 http://www.ebi.ac.uk/interpro/entry/IPR011902 InterPro IPR012336 http://www.ebi.ac.uk/interpro/entry/IPR012336 InterPro IPR014025 http://www.ebi.ac.uk/interpro/entry/IPR014025 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW0833 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0833 KEGG_Gene eco:b0849 http://www.genome.jp/dbget-bin/www_bget?eco:b0849 KEGG_Orthology KO:K03674 http://www.genome.jp/dbget-bin/www_bget?KO:K03674 OMA VGGCTEF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VGGCTEF PDB 1EGO http://www.ebi.ac.uk/pdbe-srv/view/entry/1EGO PDB 1EGR http://www.ebi.ac.uk/pdbe-srv/view/entry/1EGR PDB 1GRX http://www.ebi.ac.uk/pdbe-srv/view/entry/1GRX PDB 1QFN http://www.ebi.ac.uk/pdbe-srv/view/entry/1QFN PDB 1UPY http://www.ebi.ac.uk/pdbe-srv/view/entry/1UPY PDB 1UPZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1UPZ PDB 1UQ0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1UQ0 PDB 1UQ1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1UQ1 PDB 1UQ2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1UQ2 PDB 1UQ3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1UQ3 PDB 1UQ6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1UQ6 PDB 1UQ7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1UQ7 PDB 1UQH http://www.ebi.ac.uk/pdbe-srv/view/entry/1UQH PDB 1UQN http://www.ebi.ac.uk/pdbe-srv/view/entry/1UQN PDBsum 1EGO http://www.ebi.ac.uk/pdbsum/1EGO PDBsum 1EGR http://www.ebi.ac.uk/pdbsum/1EGR PDBsum 1GRX http://www.ebi.ac.uk/pdbsum/1GRX PDBsum 1QFN http://www.ebi.ac.uk/pdbsum/1QFN PDBsum 1UPY http://www.ebi.ac.uk/pdbsum/1UPY PDBsum 1UPZ http://www.ebi.ac.uk/pdbsum/1UPZ PDBsum 1UQ0 http://www.ebi.ac.uk/pdbsum/1UQ0 PDBsum 1UQ1 http://www.ebi.ac.uk/pdbsum/1UQ1 PDBsum 1UQ2 http://www.ebi.ac.uk/pdbsum/1UQ2 PDBsum 1UQ3 http://www.ebi.ac.uk/pdbsum/1UQ3 PDBsum 1UQ6 http://www.ebi.ac.uk/pdbsum/1UQ6 PDBsum 1UQ7 http://www.ebi.ac.uk/pdbsum/1UQ7 PDBsum 1UQH http://www.ebi.ac.uk/pdbsum/1UQH PDBsum 1UQN http://www.ebi.ac.uk/pdbsum/1UQN PRINTS PR00160 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00160 PROSITE PS00195 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00195 PROSITE PS51354 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51354 PSORT swissprot:GLRX1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLRX1_ECOLI PSORT-B swissprot:GLRX1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLRX1_ECOLI PSORT2 swissprot:GLRX1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLRX1_ECOLI Pfam PF00462 http://pfam.xfam.org/family/PF00462 Phobius swissprot:GLRX1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLRX1_ECOLI PhylomeDB P68688 http://phylomedb.org/?seqid=P68688 ProteinModelPortal P68688 http://www.proteinmodelportal.org/query/uniprot/P68688 PubMed 1304339 http://www.ncbi.nlm.nih.gov/pubmed/1304339 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1889405 http://www.ncbi.nlm.nih.gov/pubmed/1889405 PubMed 1942053 http://www.ncbi.nlm.nih.gov/pubmed/1942053 PubMed 3530878 http://www.ncbi.nlm.nih.gov/pubmed/3530878 PubMed 6352262 http://www.ncbi.nlm.nih.gov/pubmed/6352262 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9125525 http://www.ncbi.nlm.nih.gov/pubmed/9125525 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_415370 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415370 RefSeq WP_001195240 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001195240 SMR P68688 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P68688 STRING 511145.b0849 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0849&targetmode=cogs STRING COG0695 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0695&targetmode=cogs SUPFAM SSF52833 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52833 TIGRFAMs TIGR02183 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02183 UniProtKB GLRX1_ECOLI http://www.uniprot.org/uniprot/GLRX1_ECOLI UniProtKB-AC P68688 http://www.uniprot.org/uniprot/P68688 charge swissprot:GLRX1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLRX1_ECOLI eggNOG COG0695 http://eggnogapi.embl.de/nog_data/html/tree/COG0695 eggNOG ENOG41090BQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG41090BQ epestfind swissprot:GLRX1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLRX1_ECOLI garnier swissprot:GLRX1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLRX1_ECOLI helixturnhelix swissprot:GLRX1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLRX1_ECOLI hmoment swissprot:GLRX1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLRX1_ECOLI iep swissprot:GLRX1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLRX1_ECOLI inforesidue swissprot:GLRX1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLRX1_ECOLI octanol swissprot:GLRX1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLRX1_ECOLI pepcoil swissprot:GLRX1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLRX1_ECOLI pepdigest swissprot:GLRX1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLRX1_ECOLI pepinfo swissprot:GLRX1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLRX1_ECOLI pepnet swissprot:GLRX1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLRX1_ECOLI pepstats swissprot:GLRX1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLRX1_ECOLI pepwheel swissprot:GLRX1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLRX1_ECOLI pepwindow swissprot:GLRX1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLRX1_ECOLI sigcleave swissprot:GLRX1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLRX1_ECOLI ## Database ID URL or Descriptions # BioGrid 4261317 8 # EcoGene EG13465 yphD # FUNCTION YPHD_ECOLI Probably part of the binding-protein-dependent transport system YphDEF. Probably responsible for the translocation of the substrate across the membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IBA:GO_Central. # GO_function GO:0015145 monosaccharide transmembrane transporter activity; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # InterPro IPR001851 ABC_transp_permease # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00221 Putative simple sugar transport system # KEGG_Brite ko02000 Transporters # Organism YPHD_ECOLI Escherichia coli (strain K12) # PATRIC 32120489 VBIEscCol129921_2647 # PIR A65032 A65032 # Pfam PF02653 BPD_transp_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YPHD_ECOLI Probable ABC transporter permease protein YphD # RefSeq NP_417041 NC_000913.3 # RefSeq WP_001276670 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION YPHD_ECOLI Cell inner membrane {ECO 0000305}; Multi- pass membrane protein {ECO 0000305}. # TCDB 3.A.1.2.27 the atp-binding cassette (abc) superfamily # eggNOG COG1172 LUCA # eggNOG ENOG4105CNN Bacteria BLAST swissprot:YPHD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YPHD_ECOLI BioCyc ECOL316407:JW2530-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2530-MONOMER BioCyc EcoCyc:YPHD-MONOMER http://biocyc.org/getid?id=EcoCyc:YPHD-MONOMER COG COG1079 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1079 COG COG1172 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1172 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3238 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3238 EcoGene EG13465 http://www.ecogene.org/geneInfo.php?eg_id=EG13465 EnsemblBacteria AAC75599 http://www.ensemblgenomes.org/id/AAC75599 EnsemblBacteria AAC75599 http://www.ensemblgenomes.org/id/AAC75599 EnsemblBacteria BAA16448 http://www.ensemblgenomes.org/id/BAA16448 EnsemblBacteria BAA16448 http://www.ensemblgenomes.org/id/BAA16448 EnsemblBacteria BAA16448 http://www.ensemblgenomes.org/id/BAA16448 EnsemblBacteria b2546 http://www.ensemblgenomes.org/id/b2546 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015145 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GeneID 949063 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949063 HOGENOM HOG000212232 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000212232&db=HOGENOM6 InParanoid P77315 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77315 InterPro IPR001851 http://www.ebi.ac.uk/interpro/entry/IPR001851 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2530 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2530 KEGG_Gene eco:b2546 http://www.genome.jp/dbget-bin/www_bget?eco:b2546 KEGG_Orthology KO:K02057 http://www.genome.jp/dbget-bin/www_bget?KO:K02057 OMA LMIGTIN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LMIGTIN PSORT swissprot:YPHD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YPHD_ECOLI PSORT-B swissprot:YPHD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YPHD_ECOLI PSORT2 swissprot:YPHD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YPHD_ECOLI Pfam PF02653 http://pfam.xfam.org/family/PF02653 Phobius swissprot:YPHD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YPHD_ECOLI PhylomeDB P77315 http://phylomedb.org/?seqid=P77315 ProteinModelPortal P77315 http://www.proteinmodelportal.org/query/uniprot/P77315 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417041 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417041 RefSeq WP_001276670 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001276670 SMR P77315 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77315 STRING 511145.b2546 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2546&targetmode=cogs STRING COG1079 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1079&targetmode=cogs STRING COG1172 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1172&targetmode=cogs TCDB 3.A.1.2.27 http://www.tcdb.org/search/result.php?tc=3.A.1.2.27 UniProtKB YPHD_ECOLI http://www.uniprot.org/uniprot/YPHD_ECOLI UniProtKB-AC P77315 http://www.uniprot.org/uniprot/P77315 charge swissprot:YPHD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YPHD_ECOLI eggNOG COG1172 http://eggnogapi.embl.de/nog_data/html/tree/COG1172 eggNOG ENOG4105CNN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CNN epestfind swissprot:YPHD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YPHD_ECOLI garnier swissprot:YPHD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YPHD_ECOLI helixturnhelix swissprot:YPHD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YPHD_ECOLI hmoment swissprot:YPHD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YPHD_ECOLI iep swissprot:YPHD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YPHD_ECOLI inforesidue swissprot:YPHD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YPHD_ECOLI octanol swissprot:YPHD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YPHD_ECOLI pepcoil swissprot:YPHD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YPHD_ECOLI pepdigest swissprot:YPHD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YPHD_ECOLI pepinfo swissprot:YPHD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YPHD_ECOLI pepnet swissprot:YPHD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YPHD_ECOLI pepstats swissprot:YPHD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YPHD_ECOLI pepwheel swissprot:YPHD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YPHD_ECOLI pepwindow swissprot:YPHD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YPHD_ECOLI sigcleave swissprot:YPHD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YPHD_ECOLI ## Database ID URL or Descriptions # BioGrid 4262426 7 # COFACTOR YHCC_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000269|PubMed 25117543}; Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. {ECO 0000269|PubMed 25117543}; # EcoGene EG12809 yhcC # FUNCTION YHCC_ECOLI In vitro, can cleave S-adenosyl-L-methionine into methionine and 5'-deoxyadenosine (AdoH). {ECO 0000269|PubMed 25117543}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_component GO:0033588 Elongator holoenzyme complex; IBA:GO_Central. # GO_function GO:0004402 histone acetyltransferase activity; IBA:GO_Central. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0006357 regulation of transcription from RNA polymerase II promoter; IBA:GO_Central. # GO_process GO:0006368 transcription elongation from RNA polymerase II promoter; IBA:GO_Central. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.80.30.20 -; 1. # IntAct P0ADW6 10 # InterPro IPR005911 YhcC-like # InterPro IPR006638 Elp3/MiaB/NifB # InterPro IPR007197 rSAM # InterPro IPR023404 rSAM_horseshoe # InterPro IPR032432 Radical_SAM_C # Organism YHCC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11135:SF1 PTHR11135:SF1 # PATRIC 32121842 VBIEscCol129921_3305 # PIR E65112 E65112 # Pfam PF04055 Radical_SAM # Pfam PF16199 Radical_SAM_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Protein YhcC {ECO 0000305} # RefSeq NP_417678 NC_000913.3 # RefSeq WP_001299745 NZ_LN832404.1 # SIMILARITY Belongs to the radical SAM superfamily. {ECO 0000305}. # SMART SM00729 Elp3 # TIGRFAMs TIGR01212 TIGR01212 # eggNOG COG1242 LUCA # eggNOG ENOG4105N5T Bacteria BLAST swissprot:YHCC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHCC_ECOLI BioCyc ECOL316407:JW3178-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3178-MONOMER BioCyc EcoCyc:G7669-MONOMER http://biocyc.org/getid?id=EcoCyc:G7669-MONOMER COG COG1242 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1242 DIP DIP-48274N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48274N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1039/c4mt00156g http://dx.doi.org/10.1039/c4mt00156g DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L20253 http://www.ebi.ac.uk/ena/data/view/L20253 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2660 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2660 EcoGene EG12809 http://www.ecogene.org/geneInfo.php?eg_id=EG12809 EnsemblBacteria AAC76243 http://www.ensemblgenomes.org/id/AAC76243 EnsemblBacteria AAC76243 http://www.ensemblgenomes.org/id/AAC76243 EnsemblBacteria BAE77255 http://www.ensemblgenomes.org/id/BAE77255 EnsemblBacteria BAE77255 http://www.ensemblgenomes.org/id/BAE77255 EnsemblBacteria BAE77255 http://www.ensemblgenomes.org/id/BAE77255 EnsemblBacteria b3211 http://www.ensemblgenomes.org/id/b3211 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0033588 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033588 GO_function GO:0004402 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004402 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0006357 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006357 GO_process GO:0006368 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006368 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.80.30.20 http://www.cathdb.info/version/latest/superfamily/3.80.30.20 GeneID 947733 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947733 HOGENOM HOG000027270 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000027270&db=HOGENOM6 InParanoid P0ADW6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADW6 IntAct P0ADW6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADW6* InterPro IPR005911 http://www.ebi.ac.uk/interpro/entry/IPR005911 InterPro IPR006638 http://www.ebi.ac.uk/interpro/entry/IPR006638 InterPro IPR007197 http://www.ebi.ac.uk/interpro/entry/IPR007197 InterPro IPR023404 http://www.ebi.ac.uk/interpro/entry/IPR023404 InterPro IPR032432 http://www.ebi.ac.uk/interpro/entry/IPR032432 KEGG_Gene ecj:JW3178 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3178 KEGG_Gene eco:b3211 http://www.genome.jp/dbget-bin/www_bget?eco:b3211 KEGG_Orthology KO:K07139 http://www.genome.jp/dbget-bin/www_bget?KO:K07139 MINT MINT-1252681 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1252681 OMA NAGFTCP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NAGFTCP PANTHER PTHR11135:SF1 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11135:SF1 PSORT swissprot:YHCC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHCC_ECOLI PSORT-B swissprot:YHCC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHCC_ECOLI PSORT2 swissprot:YHCC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHCC_ECOLI Pfam PF04055 http://pfam.xfam.org/family/PF04055 Pfam PF16199 http://pfam.xfam.org/family/PF16199 Phobius swissprot:YHCC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHCC_ECOLI PhylomeDB P0ADW6 http://phylomedb.org/?seqid=P0ADW6 ProteinModelPortal P0ADW6 http://www.proteinmodelportal.org/query/uniprot/P0ADW6 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 25117543 http://www.ncbi.nlm.nih.gov/pubmed/25117543 PubMed 7901196 http://www.ncbi.nlm.nih.gov/pubmed/7901196 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417678 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417678 RefSeq WP_001299745 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001299745 SMART SM00729 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00729 SMR P0ADW6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADW6 STRING 511145.b3211 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3211&targetmode=cogs STRING COG1242 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1242&targetmode=cogs TIGRFAMs TIGR01212 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01212 UniProtKB YHCC_ECOLI http://www.uniprot.org/uniprot/YHCC_ECOLI UniProtKB-AC P0ADW6 http://www.uniprot.org/uniprot/P0ADW6 charge swissprot:YHCC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHCC_ECOLI eggNOG COG1242 http://eggnogapi.embl.de/nog_data/html/tree/COG1242 eggNOG ENOG4105N5T http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105N5T epestfind swissprot:YHCC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHCC_ECOLI garnier swissprot:YHCC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHCC_ECOLI helixturnhelix swissprot:YHCC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHCC_ECOLI hmoment swissprot:YHCC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHCC_ECOLI iep swissprot:YHCC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHCC_ECOLI inforesidue swissprot:YHCC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHCC_ECOLI octanol swissprot:YHCC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHCC_ECOLI pepcoil swissprot:YHCC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHCC_ECOLI pepdigest swissprot:YHCC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHCC_ECOLI pepinfo swissprot:YHCC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHCC_ECOLI pepnet swissprot:YHCC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHCC_ECOLI pepstats swissprot:YHCC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHCC_ECOLI pepwheel swissprot:YHCC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHCC_ECOLI pepwindow swissprot:YHCC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHCC_ECOLI sigcleave swissprot:YHCC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHCC_ECOLI ## Database ID URL or Descriptions # BioGrid 4262366 14 # EcoGene EG13291 glcF # GO_function GO:0019154 glycolate dehydrogenase activity; IMP:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0046296 glycolate catabolic process; IMP:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # InterPro IPR004017 Cys_rich_dom # InterPro IPR012257 Glc_ox_4Fe-4S # InterPro IPR017896 4Fe4S_Fe-S-bd # InterPro IPR017900 4Fe4S_Fe_S_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Pathway ko00630 Glyoxylate and dicarboxylate metabolism # Organism GLCF_ECOLI Escherichia coli (strain K12) # PATRIC 32121370 VBIEscCol129921_3072 # PIRSF PIRSF000139 Glc_ox_4Fe-4S # PROSITE PS00198 4FE4S_FER_1; 2 # PROSITE PS51379 4FE4S_FER_2; 2 # Pfam PF02754 CCG; 2 # Pfam PF13183 Fer4_8 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLCF_ECOLI Glycolate oxidase iron-sulfur subunit # RefSeq WP_001194661 NZ_LN832404.1 # RefSeq YP_026190 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA69145.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Contains 2 4Fe-4S ferredoxin-type domains. {ECO:0000255|PROSITE-ProRule PRU00711}. # eggNOG COG0247 LUCA # eggNOG ENOG4105CHG Bacteria BLAST swissprot:GLCF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLCF_ECOLI BioCyc ECOL316407:JW5486-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5486-MONOMER BioCyc EcoCyc:MONOMER0-561 http://biocyc.org/getid?id=EcoCyc:MONOMER0-561 BioCyc MetaCyc:MONOMER0-561 http://biocyc.org/getid?id=MetaCyc:MONOMER0-561 COG COG0247 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0247 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L43490 http://www.ebi.ac.uk/ena/data/view/L43490 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB3076 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3076 EcoGene EG13291 http://www.ecogene.org/geneInfo.php?eg_id=EG13291 EnsemblBacteria AAT48157 http://www.ensemblgenomes.org/id/AAT48157 EnsemblBacteria AAT48157 http://www.ensemblgenomes.org/id/AAT48157 EnsemblBacteria BAE77038 http://www.ensemblgenomes.org/id/BAE77038 EnsemblBacteria BAE77038 http://www.ensemblgenomes.org/id/BAE77038 EnsemblBacteria BAE77038 http://www.ensemblgenomes.org/id/BAE77038 EnsemblBacteria b4467 http://www.ensemblgenomes.org/id/b4467 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0019154 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019154 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0046296 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046296 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 2847717 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2847717 HOGENOM HOG000256469 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000256469&db=HOGENOM6 InParanoid P52074 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P52074 InterPro IPR004017 http://www.ebi.ac.uk/interpro/entry/IPR004017 InterPro IPR012257 http://www.ebi.ac.uk/interpro/entry/IPR012257 InterPro IPR017896 http://www.ebi.ac.uk/interpro/entry/IPR017896 InterPro IPR017900 http://www.ebi.ac.uk/interpro/entry/IPR017900 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Gene ecj:JW5486 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5486 KEGG_Gene eco:b4467 http://www.genome.jp/dbget-bin/www_bget?eco:b4467 KEGG_Orthology KO:K11473 http://www.genome.jp/dbget-bin/www_bget?KO:K11473 KEGG_Pathway ko00630 http://www.genome.jp/kegg-bin/show_pathway?ko00630 KEGG_Reaction rn:R00475 http://www.genome.jp/dbget-bin/www_bget?rn:R00475 OMA HWIELLD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HWIELLD PROSITE PS00198 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00198 PROSITE PS51379 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51379 PSORT swissprot:GLCF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLCF_ECOLI PSORT-B swissprot:GLCF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLCF_ECOLI PSORT2 swissprot:GLCF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLCF_ECOLI Pfam PF02754 http://pfam.xfam.org/family/PF02754 Pfam PF13183 http://pfam.xfam.org/family/PF13183 Phobius swissprot:GLCF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLCF_ECOLI PhylomeDB P52074 http://phylomedb.org/?seqid=P52074 ProteinModelPortal P52074 http://www.proteinmodelportal.org/query/uniprot/P52074 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8606183 http://www.ncbi.nlm.nih.gov/pubmed/8606183 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001194661 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001194661 RefSeq YP_026190 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026190 STRING 511145.b4467 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4467&targetmode=cogs STRING COG0247 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0247&targetmode=cogs UniProtKB GLCF_ECOLI http://www.uniprot.org/uniprot/GLCF_ECOLI UniProtKB-AC P52074 http://www.uniprot.org/uniprot/P52074 charge swissprot:GLCF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLCF_ECOLI eggNOG COG0247 http://eggnogapi.embl.de/nog_data/html/tree/COG0247 eggNOG ENOG4105CHG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CHG epestfind swissprot:GLCF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLCF_ECOLI garnier swissprot:GLCF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLCF_ECOLI helixturnhelix swissprot:GLCF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLCF_ECOLI hmoment swissprot:GLCF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLCF_ECOLI iep swissprot:GLCF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLCF_ECOLI inforesidue swissprot:GLCF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLCF_ECOLI octanol swissprot:GLCF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLCF_ECOLI pepcoil swissprot:GLCF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLCF_ECOLI pepdigest swissprot:GLCF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLCF_ECOLI pepinfo swissprot:GLCF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLCF_ECOLI pepnet swissprot:GLCF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLCF_ECOLI pepstats swissprot:GLCF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLCF_ECOLI pepwheel swissprot:GLCF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLCF_ECOLI pepwindow swissprot:GLCF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLCF_ECOLI sigcleave swissprot:GLCF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLCF_ECOLI ## Database ID URL or Descriptions # BioGrid 4260936 6 # EcoGene EG12747 yhaH # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR008523 DUF805 # Organism YHAH_ECOLI Escherichia coli (strain K12) # PATRIC 32121626 VBIEscCol129921_3199 # PIR D65099 D65099 # Pfam PF05656 DUF805 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHAH_ECOLI Inner membrane protein YhaH # RefSeq NP_417574 NC_000913.3 # RefSeq WP_000384145 NZ_LN832404.1 # SIMILARITY To E.coli YhaI. {ECO 0000305}. # SUBCELLULAR LOCATION YHAH_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG COG3152 LUCA # eggNOG ENOG4105KAF Bacteria BLAST swissprot:YHAH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHAH_ECOLI BioCyc ECOL316407:JW3074-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3074-MONOMER BioCyc EcoCyc:G7617-MONOMER http://biocyc.org/getid?id=EcoCyc:G7617-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2603 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2603 EcoGene EG12747 http://www.ecogene.org/geneInfo.php?eg_id=EG12747 EnsemblBacteria AAC76138 http://www.ensemblgenomes.org/id/AAC76138 EnsemblBacteria AAC76138 http://www.ensemblgenomes.org/id/AAC76138 EnsemblBacteria BAE77153 http://www.ensemblgenomes.org/id/BAE77153 EnsemblBacteria BAE77153 http://www.ensemblgenomes.org/id/BAE77153 EnsemblBacteria BAE77153 http://www.ensemblgenomes.org/id/BAE77153 EnsemblBacteria b3103 http://www.ensemblgenomes.org/id/b3103 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 947617 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947617 HOGENOM HOG000253106 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000253106&db=HOGENOM6 InParanoid P64590 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P64590 InterPro IPR008523 http://www.ebi.ac.uk/interpro/entry/IPR008523 KEGG_Gene ecj:JW3074 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3074 KEGG_Gene eco:b3103 http://www.genome.jp/dbget-bin/www_bget?eco:b3103 OMA MVYLLAN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MVYLLAN PSORT swissprot:YHAH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHAH_ECOLI PSORT-B swissprot:YHAH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHAH_ECOLI PSORT2 swissprot:YHAH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHAH_ECOLI Pfam PF05656 http://pfam.xfam.org/family/PF05656 Phobius swissprot:YHAH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHAH_ECOLI PhylomeDB P64590 http://phylomedb.org/?seqid=P64590 ProteinModelPortal P64590 http://www.proteinmodelportal.org/query/uniprot/P64590 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417574 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417574 RefSeq WP_000384145 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000384145 STRING 511145.b3103 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3103&targetmode=cogs UniProtKB YHAH_ECOLI http://www.uniprot.org/uniprot/YHAH_ECOLI UniProtKB-AC P64590 http://www.uniprot.org/uniprot/P64590 charge swissprot:YHAH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHAH_ECOLI eggNOG COG3152 http://eggnogapi.embl.de/nog_data/html/tree/COG3152 eggNOG ENOG4105KAF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KAF epestfind swissprot:YHAH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHAH_ECOLI garnier swissprot:YHAH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHAH_ECOLI helixturnhelix swissprot:YHAH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHAH_ECOLI hmoment swissprot:YHAH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHAH_ECOLI iep swissprot:YHAH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHAH_ECOLI inforesidue swissprot:YHAH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHAH_ECOLI octanol swissprot:YHAH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHAH_ECOLI pepcoil swissprot:YHAH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHAH_ECOLI pepdigest swissprot:YHAH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHAH_ECOLI pepinfo swissprot:YHAH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHAH_ECOLI pepnet swissprot:YHAH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHAH_ECOLI pepstats swissprot:YHAH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHAH_ECOLI pepwheel swissprot:YHAH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHAH_ECOLI pepwindow swissprot:YHAH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHAH_ECOLI sigcleave swissprot:YHAH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHAH_ECOLI ## Database ID URL or Descriptions # BioGrid 4261938 418 # EcoGene EG11555 yaaJ # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function YAAJ_ECOLI GO 0015655 alanine sodium symporter activity; IEA InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # InterPro IPR001463 Na/Ala_symport # Organism YAAJ_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30330 PTHR30330 # PATRIC 32115109 VBIEscCol129921_0006 # PIR G64720 G64720 # PRINTS PR00175 NAALASMPORT # PROSITE PS00873 NA_ALANINE_SYMP # Pfam PF01235 Na_Ala_symp # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAAJ_ECOLI Uncharacterized transporter YaaJ # RefSeq NP_414548 NC_000913.3 # RefSeq WP_001112606 NZ_LN832404.1 # SIMILARITY Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family. {ECO 0000305}. # SUBCELLULAR LOCATION YAAJ_ECOLI Cell inner membrane {ECO 0000305}; Multi- pass membrane protein {ECO 0000305}. # TCDB 2.A.25.1.10:the alanine or glycine cation symporter (agcs) family # TIGRFAMs TIGR00835 agcS # eggNOG COG1115 LUCA # eggNOG ENOG4105BZG Bacteria BLAST swissprot:YAAJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAAJ_ECOLI BioCyc ECOL316407:JW0006-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0006-MONOMER BioCyc EcoCyc:YAAJ-MONOMER http://biocyc.org/getid?id=EcoCyc:YAAJ-MONOMER COG COG1115 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1115 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1516 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1516 EcoGene EG11555 http://www.ecogene.org/geneInfo.php?eg_id=EG11555 EnsemblBacteria AAC73118 http://www.ensemblgenomes.org/id/AAC73118 EnsemblBacteria AAC73118 http://www.ensemblgenomes.org/id/AAC73118 EnsemblBacteria BAB96585 http://www.ensemblgenomes.org/id/BAB96585 EnsemblBacteria BAB96585 http://www.ensemblgenomes.org/id/BAB96585 EnsemblBacteria BAB96585 http://www.ensemblgenomes.org/id/BAB96585 EnsemblBacteria b0007 http://www.ensemblgenomes.org/id/b0007 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015655 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GeneID 944745 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944745 HOGENOM HOG000255107 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000255107&db=HOGENOM6 InParanoid P30143 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30143 InterPro IPR001463 http://www.ebi.ac.uk/interpro/entry/IPR001463 KEGG_Gene ecj:JW0006 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0006 KEGG_Gene eco:b0007 http://www.genome.jp/dbget-bin/www_bget?eco:b0007 KEGG_Orthology KO:K03310 http://www.genome.jp/dbget-bin/www_bget?KO:K03310 OMA CAFGWQE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CAFGWQE PANTHER PTHR30330 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30330 PRINTS PR00175 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00175 PROSITE PS00873 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00873 PSORT swissprot:YAAJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAAJ_ECOLI PSORT-B swissprot:YAAJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAAJ_ECOLI PSORT2 swissprot:YAAJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAAJ_ECOLI Pfam PF01235 http://pfam.xfam.org/family/PF01235 Phobius swissprot:YAAJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAAJ_ECOLI PhylomeDB P30143 http://phylomedb.org/?seqid=P30143 ProteinModelPortal P30143 http://www.proteinmodelportal.org/query/uniprot/P30143 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414548 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414548 RefSeq WP_001112606 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001112606 STRING 511145.b0007 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0007&targetmode=cogs STRING COG1115 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1115&targetmode=cogs TCDB 2.A.25.1.10 http://www.tcdb.org/search/result.php?tc=2.A.25.1.10 TIGRFAMs TIGR00835 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00835 UniProtKB YAAJ_ECOLI http://www.uniprot.org/uniprot/YAAJ_ECOLI UniProtKB-AC P30143 http://www.uniprot.org/uniprot/P30143 charge swissprot:YAAJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAAJ_ECOLI eggNOG COG1115 http://eggnogapi.embl.de/nog_data/html/tree/COG1115 eggNOG ENOG4105BZG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZG epestfind swissprot:YAAJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAAJ_ECOLI garnier swissprot:YAAJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAAJ_ECOLI helixturnhelix swissprot:YAAJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAAJ_ECOLI hmoment swissprot:YAAJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAAJ_ECOLI iep swissprot:YAAJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAAJ_ECOLI inforesidue swissprot:YAAJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAAJ_ECOLI octanol swissprot:YAAJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAAJ_ECOLI pepcoil swissprot:YAAJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAAJ_ECOLI pepdigest swissprot:YAAJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAAJ_ECOLI pepinfo swissprot:YAAJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAAJ_ECOLI pepnet swissprot:YAAJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAAJ_ECOLI pepstats swissprot:YAAJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAAJ_ECOLI pepwheel swissprot:YAAJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAAJ_ECOLI pepwindow swissprot:YAAJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAAJ_ECOLI sigcleave swissprot:YAAJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAAJ_ECOLI ## Database ID URL or Descriptions # AltName DDLA_ECOLI D-Ala-D-Ala ligase A # AltName DDLA_ECOLI D-alanylalanine synthetase A # BioGrid 4261531 455 # CATALYTIC ACTIVITY DDLA_ECOLI ATP + 2 D-alanine = ADP + phosphate + D- alanyl-D-alanine. # COFACTOR DDLA_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000250}; Note=Binds 2 magnesium or manganese ions per subunit. {ECO 0000250}; # DrugBank DB00260 Cycloserine # EcoGene EG10213 ddlA # FUNCTION DDLA_ECOLI Cell wall formation. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008716 D-alanine-D-alanine ligase activity; IDA:EcoCyc. # GO_function GO:0030145 manganese ion binding; IEA:UniProtKB-HAMAP. # GO_process GO:0008360 regulation of cell shape; IEA:UniProtKB-KW. # GO_process GO:0009252 peptidoglycan biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 3.30.1490.20 -; 1. # Gene3D 3.30.470.20 -; 1. # Gene3D 3.40.50.20 -; 1. # HAMAP MF_00047 Dala_Dala_lig # IntAct P0A6J8 14 # InterPro IPR000291 D-Ala_lig_Van_CS # InterPro IPR005905 D_ala_D_ala # InterPro IPR011095 Dala_Dala_lig_C # InterPro IPR011127 Dala_Dala_lig_N # InterPro IPR011761 ATP-grasp # InterPro IPR013815 ATP_grasp_subdomain_1 # InterPro IPR013816 ATP_grasp_subdomain_2 # InterPro IPR016185 PreATP-grasp_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00473 D-Alanine metabolism # KEGG_Pathway ko00550 Peptidoglycan biosynthesis # Organism DDLA_ECOLI Escherichia coli (strain K12) # PATHWAY DDLA_ECOLI Cell wall biogenesis; peptidoglycan biosynthesis. # PATRIC 32115903 VBIEscCol129921_0393 # PIR A39182 CEECDA # PIRSF PIRSF039102 Ddl/VanB # PROSITE PS00843 DALA_DALA_LIGASE_1 # PROSITE PS00844 DALA_DALA_LIGASE_2 # PROSITE PS50975 ATP_GRASP # Pfam PF01820 Dala_Dala_lig_N # Pfam PF07478 Dala_Dala_lig_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DDLA_ECOLI D-alanine--D-alanine ligase A # RefSeq NP_414915 NC_000913.3 # RefSeq WP_000413677 NZ_LN832404.1 # SIMILARITY Belongs to the D-alanine--D-alanine ligase family. {ECO 0000305}. # SIMILARITY Contains 1 ATP-grasp domain. {ECO 0000305}. # SUBCELLULAR LOCATION DDLA_ECOLI Cytoplasm. # SUPFAM SSF52440 SSF52440 # TIGRFAMs TIGR01205 D_ala_D_alaTIGR # eggNOG COG1181 LUCA # eggNOG ENOG4105CPF Bacteria BLAST swissprot:DDLA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DDLA_ECOLI BioCyc ECOL316407:JW0372-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0372-MONOMER BioCyc EcoCyc:DALADALALIGA-MONOMER http://biocyc.org/getid?id=EcoCyc:DALADALALIGA-MONOMER BioCyc MetaCyc:DALADALALIGA-MONOMER http://biocyc.org/getid?id=MetaCyc:DALADALALIGA-MONOMER COG COG1181 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1181 DIP DIP-47939N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47939N DOI 10.1021/bi00220a033 http://dx.doi.org/10.1021/bi00220a033 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB00260 http://www.drugbank.ca/drugs/DB00260 EC_number EC:6.3.2.4 http://www.genome.jp/dbget-bin/www_bget?EC:6.3.2.4 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M58467 http://www.ebi.ac.uk/ena/data/view/M58467 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 ENZYME 6.3.2.4 http://enzyme.expasy.org/EC/6.3.2.4 EchoBASE EB0209 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0209 EcoGene EG10213 http://www.ecogene.org/geneInfo.php?eg_id=EG10213 EnsemblBacteria AAC73484 http://www.ensemblgenomes.org/id/AAC73484 EnsemblBacteria AAC73484 http://www.ensemblgenomes.org/id/AAC73484 EnsemblBacteria BAE76162 http://www.ensemblgenomes.org/id/BAE76162 EnsemblBacteria BAE76162 http://www.ensemblgenomes.org/id/BAE76162 EnsemblBacteria BAE76162 http://www.ensemblgenomes.org/id/BAE76162 EnsemblBacteria b0381 http://www.ensemblgenomes.org/id/b0381 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008716 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008716 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0009252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009252 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 3.30.1490.20 http://www.cathdb.info/version/latest/superfamily/3.30.1490.20 Gene3D 3.30.470.20 http://www.cathdb.info/version/latest/superfamily/3.30.470.20 Gene3D 3.40.50.20 http://www.cathdb.info/version/latest/superfamily/3.40.50.20 GeneID 945313 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945313 HAMAP MF_00047 http://hamap.expasy.org/unirule/MF_00047 HOGENOM HOG000011593 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000011593&db=HOGENOM6 InParanoid P0A6J8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6J8 IntAct P0A6J8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6J8* IntEnz 6.3.2.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.2.4 InterPro IPR000291 http://www.ebi.ac.uk/interpro/entry/IPR000291 InterPro IPR005905 http://www.ebi.ac.uk/interpro/entry/IPR005905 InterPro IPR011095 http://www.ebi.ac.uk/interpro/entry/IPR011095 InterPro IPR011127 http://www.ebi.ac.uk/interpro/entry/IPR011127 InterPro IPR011761 http://www.ebi.ac.uk/interpro/entry/IPR011761 InterPro IPR013815 http://www.ebi.ac.uk/interpro/entry/IPR013815 InterPro IPR013816 http://www.ebi.ac.uk/interpro/entry/IPR013816 InterPro IPR016185 http://www.ebi.ac.uk/interpro/entry/IPR016185 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0372 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0372 KEGG_Gene eco:b0381 http://www.genome.jp/dbget-bin/www_bget?eco:b0381 KEGG_Orthology KO:K01921 http://www.genome.jp/dbget-bin/www_bget?KO:K01921 KEGG_Pathway ko00473 http://www.genome.jp/kegg-bin/show_pathway?ko00473 KEGG_Pathway ko00550 http://www.genome.jp/kegg-bin/show_pathway?ko00550 KEGG_Reaction rn:R01150 http://www.genome.jp/dbget-bin/www_bget?rn:R01150 OMA MDKIAMK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MDKIAMK PROSITE PS00843 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00843 PROSITE PS00844 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00844 PROSITE PS50975 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50975 PSORT swissprot:DDLA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DDLA_ECOLI PSORT-B swissprot:DDLA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DDLA_ECOLI PSORT2 swissprot:DDLA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DDLA_ECOLI Pfam PF01820 http://pfam.xfam.org/family/PF01820 Pfam PF07478 http://pfam.xfam.org/family/PF07478 Phobius swissprot:DDLA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DDLA_ECOLI PhylomeDB P0A6J8 http://phylomedb.org/?seqid=P0A6J8 ProteinModelPortal P0A6J8 http://www.proteinmodelportal.org/query/uniprot/P0A6J8 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1993184 http://www.ncbi.nlm.nih.gov/pubmed/1993184 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414915 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414915 RefSeq WP_000413677 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000413677 SMR P0A6J8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6J8 STRING 511145.b0381 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0381&targetmode=cogs STRING COG1181 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1181&targetmode=cogs SUPFAM SSF52440 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52440 TIGRFAMs TIGR01205 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01205 UniProtKB DDLA_ECOLI http://www.uniprot.org/uniprot/DDLA_ECOLI UniProtKB-AC P0A6J8 http://www.uniprot.org/uniprot/P0A6J8 charge swissprot:DDLA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DDLA_ECOLI eggNOG COG1181 http://eggnogapi.embl.de/nog_data/html/tree/COG1181 eggNOG ENOG4105CPF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CPF epestfind swissprot:DDLA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DDLA_ECOLI garnier swissprot:DDLA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DDLA_ECOLI helixturnhelix swissprot:DDLA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DDLA_ECOLI hmoment swissprot:DDLA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DDLA_ECOLI iep swissprot:DDLA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DDLA_ECOLI inforesidue swissprot:DDLA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DDLA_ECOLI octanol swissprot:DDLA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DDLA_ECOLI pepcoil swissprot:DDLA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DDLA_ECOLI pepdigest swissprot:DDLA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DDLA_ECOLI pepinfo swissprot:DDLA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DDLA_ECOLI pepnet swissprot:DDLA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DDLA_ECOLI pepstats swissprot:DDLA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DDLA_ECOLI pepwheel swissprot:DDLA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DDLA_ECOLI pepwindow swissprot:DDLA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DDLA_ECOLI sigcleave swissprot:DDLA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DDLA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261457 783 # EcoGene EG12685 ygfZ # FUNCTION YGFZ_ECOLI Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication. {ECO 0000269|PubMed 16359333}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0005542 folic acid binding; IDA:EcoCyc. # GO_process GO:0008033 tRNA processing; IEA:UniProtKB-HAMAP. # GO_process GO:0009451 RNA modification; IEA:InterPro. # GO_process GO:0016226 iron-sulfur cluster assembly; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0051186 cofactor metabolic process # HAMAP MF_01175 tRNA_modifying_YgfZ # IntAct P0ADE8 6 # InterPro IPR006222 GCV_T_N # InterPro IPR017703 YgfZ/GcvT_CS # InterPro IPR023758 tRNA-modifying_YgfZ # InterPro IPR029043 GcvT/YgfZ_C # Organism YGFZ_ECOLI Escherichia coli (strain K12) # PATRIC 32121210 VBIEscCol129921_2993 # PDB 1NRK X-ray; 2.80 A; A=1-325 # PDB 1VLY X-ray; 1.30 A; A=1-326 # PIR B65074 B65074 # Pfam PF01571 GCV_T # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGFZ_ECOLI tRNA-modifying protein YgfZ # RefSeq NP_417374 NC_000913.3 # RefSeq WP_000886062 NZ_LN832404.1 # SIMILARITY Belongs to the tRNA-modifying YgfZ family. {ECO 0000305}. # SUBCELLULAR LOCATION YGFZ_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF101790 SSF101790 # TIGRFAMs TIGR03317 ygfZ_signature # eggNOG COG0354 LUCA # eggNOG ENOG4106XY2 Bacteria BLAST swissprot:YGFZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGFZ_ECOLI BioCyc ECOL316407:JW2866-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2866-MONOMER BioCyc EcoCyc:G7511-MONOMER http://biocyc.org/getid?id=EcoCyc:G7511-MONOMER COG COG0354 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0354 DIP DIP-48117N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48117N DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2005.04932.x http://dx.doi.org/10.1111/j.1365-2958.2005.04932.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.186.21.7134-7140.2004 http://dx.doi.org/10.1128/JB.186.21.7134-7140.2004 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 EchoBASE EB2549 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2549 EcoGene EG12685 http://www.ecogene.org/geneInfo.php?eg_id=EG12685 EnsemblBacteria AAC75936 http://www.ensemblgenomes.org/id/AAC75936 EnsemblBacteria AAC75936 http://www.ensemblgenomes.org/id/AAC75936 EnsemblBacteria BAE76963 http://www.ensemblgenomes.org/id/BAE76963 EnsemblBacteria BAE76963 http://www.ensemblgenomes.org/id/BAE76963 EnsemblBacteria BAE76963 http://www.ensemblgenomes.org/id/BAE76963 EnsemblBacteria b2898 http://www.ensemblgenomes.org/id/b2898 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0005542 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005542 GO_process GO:0008033 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008033 GO_process GO:0009451 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009451 GO_process GO:0016226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016226 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GeneID 947384 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947384 HAMAP MF_01175 http://hamap.expasy.org/unirule/MF_01175 HOGENOM HOG000261300 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261300&db=HOGENOM6 InParanoid P0ADE8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADE8 IntAct P0ADE8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADE8* InterPro IPR006222 http://www.ebi.ac.uk/interpro/entry/IPR006222 InterPro IPR017703 http://www.ebi.ac.uk/interpro/entry/IPR017703 InterPro IPR023758 http://www.ebi.ac.uk/interpro/entry/IPR023758 InterPro IPR029043 http://www.ebi.ac.uk/interpro/entry/IPR029043 KEGG_Gene ecj:JW2866 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2866 KEGG_Gene eco:b2898 http://www.genome.jp/dbget-bin/www_bget?eco:b2898 KEGG_Orthology KO:K06980 http://www.genome.jp/dbget-bin/www_bget?KO:K06980 MINT MINT-1257340 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1257340 OMA GRMQSSF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GRMQSSF PDB 1NRK http://www.ebi.ac.uk/pdbe-srv/view/entry/1NRK PDB 1VLY http://www.ebi.ac.uk/pdbe-srv/view/entry/1VLY PDBsum 1NRK http://www.ebi.ac.uk/pdbsum/1NRK PDBsum 1VLY http://www.ebi.ac.uk/pdbsum/1VLY PSORT swissprot:YGFZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGFZ_ECOLI PSORT-B swissprot:YGFZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGFZ_ECOLI PSORT2 swissprot:YGFZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGFZ_ECOLI Pfam PF01571 http://pfam.xfam.org/family/PF01571 Phobius swissprot:YGFZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGFZ_ECOLI PhylomeDB P0ADE8 http://phylomedb.org/?seqid=P0ADE8 ProteinModelPortal P0ADE8 http://www.proteinmodelportal.org/query/uniprot/P0ADE8 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 15489424 http://www.ncbi.nlm.nih.gov/pubmed/15489424 PubMed 16359333 http://www.ncbi.nlm.nih.gov/pubmed/16359333 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_417374 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417374 RefSeq WP_000886062 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000886062 SMR P0ADE8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADE8 STRING 511145.b2898 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2898&targetmode=cogs STRING COG0354 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0354&targetmode=cogs SUPFAM SSF101790 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF101790 SWISS-2DPAGE P0ADE8 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0ADE8 TIGRFAMs TIGR03317 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03317 UniProtKB YGFZ_ECOLI http://www.uniprot.org/uniprot/YGFZ_ECOLI UniProtKB-AC P0ADE8 http://www.uniprot.org/uniprot/P0ADE8 charge swissprot:YGFZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGFZ_ECOLI eggNOG COG0354 http://eggnogapi.embl.de/nog_data/html/tree/COG0354 eggNOG ENOG4106XY2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106XY2 epestfind swissprot:YGFZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGFZ_ECOLI garnier swissprot:YGFZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGFZ_ECOLI helixturnhelix swissprot:YGFZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGFZ_ECOLI hmoment swissprot:YGFZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGFZ_ECOLI iep swissprot:YGFZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGFZ_ECOLI inforesidue swissprot:YGFZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGFZ_ECOLI octanol swissprot:YGFZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGFZ_ECOLI pepcoil swissprot:YGFZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGFZ_ECOLI pepdigest swissprot:YGFZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGFZ_ECOLI pepinfo swissprot:YGFZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGFZ_ECOLI pepnet swissprot:YGFZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGFZ_ECOLI pepstats swissprot:YGFZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGFZ_ECOLI pepwheel swissprot:YGFZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGFZ_ECOLI pepwindow swissprot:YGFZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGFZ_ECOLI sigcleave swissprot:YGFZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGFZ_ECOLI ## Database ID URL or Descriptions # BioGrid 4260418 6 # EcoGene EG13393 yeeZ # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003824 catalytic activity; IEA:InterPro. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0050662 coenzyme binding; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.720 -; 2. # IntAct P0AD12 7 # InterPro IPR001509 Epimerase_deHydtase # InterPro IPR016040 NAD(P)-bd_dom # Organism YEEZ_ECOLI Escherichia coli (strain K12) # PATRIC 32119367 VBIEscCol129921_2093 # PIR G64966 G64966 # Pfam PF01370 Epimerase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEEZ_ECOLI Protein YeeZ # RefSeq NP_416520 NC_000913.3 # RefSeq WP_000754737 NZ_LN832404.1 # SUPFAM SSF51735 SSF51735 # eggNOG COG0451 LUCA # eggNOG ENOG4107SRH Bacteria BLAST swissprot:YEEZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEEZ_ECOLI BioCyc ECOL316407:JW1998-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1998-MONOMER BioCyc EcoCyc:G7089-MONOMER http://biocyc.org/getid?id=EcoCyc:G7089-MONOMER DIP DIP-35847N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35847N DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3174 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3174 EcoGene EG13393 http://www.ecogene.org/geneInfo.php?eg_id=EG13393 EnsemblBacteria AAC75077 http://www.ensemblgenomes.org/id/AAC75077 EnsemblBacteria AAC75077 http://www.ensemblgenomes.org/id/AAC75077 EnsemblBacteria BAE76568 http://www.ensemblgenomes.org/id/BAE76568 EnsemblBacteria BAE76568 http://www.ensemblgenomes.org/id/BAE76568 EnsemblBacteria BAE76568 http://www.ensemblgenomes.org/id/BAE76568 EnsemblBacteria b2016 http://www.ensemblgenomes.org/id/b2016 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003824 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003824 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0050662 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050662 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 946538 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946538 HOGENOM HOG000275399 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275399&db=HOGENOM6 InParanoid P0AD12 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AD12 IntAct P0AD12 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AD12* InterPro IPR001509 http://www.ebi.ac.uk/interpro/entry/IPR001509 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 KEGG_Gene ecj:JW1998 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1998 KEGG_Gene eco:b2016 http://www.genome.jp/dbget-bin/www_bget?eco:b2016 OMA NLCAPAH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NLCAPAH PSORT swissprot:YEEZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEEZ_ECOLI PSORT-B swissprot:YEEZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEEZ_ECOLI PSORT2 swissprot:YEEZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEEZ_ECOLI Pfam PF01370 http://pfam.xfam.org/family/PF01370 Phobius swissprot:YEEZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEEZ_ECOLI PhylomeDB P0AD12 http://phylomedb.org/?seqid=P0AD12 ProteinModelPortal P0AD12 http://www.proteinmodelportal.org/query/uniprot/P0AD12 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416520 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416520 RefSeq WP_000754737 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000754737 STRING 511145.b2016 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2016&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB YEEZ_ECOLI http://www.uniprot.org/uniprot/YEEZ_ECOLI UniProtKB-AC P0AD12 http://www.uniprot.org/uniprot/P0AD12 charge swissprot:YEEZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEEZ_ECOLI eggNOG COG0451 http://eggnogapi.embl.de/nog_data/html/tree/COG0451 eggNOG ENOG4107SRH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107SRH epestfind swissprot:YEEZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEEZ_ECOLI garnier swissprot:YEEZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEEZ_ECOLI helixturnhelix swissprot:YEEZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEEZ_ECOLI hmoment swissprot:YEEZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEEZ_ECOLI iep swissprot:YEEZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEEZ_ECOLI inforesidue swissprot:YEEZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEEZ_ECOLI octanol swissprot:YEEZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEEZ_ECOLI pepcoil swissprot:YEEZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEEZ_ECOLI pepdigest swissprot:YEEZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEEZ_ECOLI pepinfo swissprot:YEEZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEEZ_ECOLI pepnet swissprot:YEEZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEEZ_ECOLI pepstats swissprot:YEEZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEEZ_ECOLI pepwheel swissprot:YEEZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEEZ_ECOLI pepwindow swissprot:YEEZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEEZ_ECOLI sigcleave swissprot:YEEZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEEZ_ECOLI ## Database ID URL or Descriptions # BioGrid 4260005 13 # EcoGene EG13700 ycaP # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # Gene3D 3.30.240.20 -; 1. # InterPro IPR007353 DUF421 # InterPro IPR023090 UPF0702_alpha/beta_dom # Organism YCAP_ECOLI Escherichia coli (strain K12) # PATRIC 32117025 VBIEscCol129921_0937 # PIR A64830 A64830 # Pfam PF04239 DUF421 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCAP_ECOLI UPF0702 transmembrane protein YcaP # RefSeq NP_415426 NC_000913.3 # RefSeq WP_000642849 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0702 family. {ECO 0000305}. # SUBCELLULAR LOCATION YCAP_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # eggNOG COG2323 LUCA # eggNOG ENOG4107VMU Bacteria BLAST swissprot:YCAP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCAP_ECOLI BioCyc ECOL316407:JW0889-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0889-MONOMER BioCyc EcoCyc:G6469-MONOMER http://biocyc.org/getid?id=EcoCyc:G6469-MONOMER DIP DIP-11471N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11471N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3464 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3464 EcoGene EG13700 http://www.ecogene.org/geneInfo.php?eg_id=EG13700 EnsemblBacteria AAC73992 http://www.ensemblgenomes.org/id/AAC73992 EnsemblBacteria AAC73992 http://www.ensemblgenomes.org/id/AAC73992 EnsemblBacteria BAA35641 http://www.ensemblgenomes.org/id/BAA35641 EnsemblBacteria BAA35641 http://www.ensemblgenomes.org/id/BAA35641 EnsemblBacteria BAA35641 http://www.ensemblgenomes.org/id/BAA35641 EnsemblBacteria b0906 http://www.ensemblgenomes.org/id/b0906 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 Gene3D 3.30.240.20 http://www.cathdb.info/version/latest/superfamily/3.30.240.20 GeneID 945525 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945525 HOGENOM HOG000118751 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118751&db=HOGENOM6 InParanoid P75839 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75839 InterPro IPR007353 http://www.ebi.ac.uk/interpro/entry/IPR007353 InterPro IPR023090 http://www.ebi.ac.uk/interpro/entry/IPR023090 KEGG_Gene ecj:JW0889 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0889 KEGG_Gene eco:b0906 http://www.genome.jp/dbget-bin/www_bget?eco:b0906 OMA LAIMETN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LAIMETN PSORT swissprot:YCAP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCAP_ECOLI PSORT-B swissprot:YCAP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCAP_ECOLI PSORT2 swissprot:YCAP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCAP_ECOLI Pfam PF04239 http://pfam.xfam.org/family/PF04239 Phobius swissprot:YCAP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCAP_ECOLI PhylomeDB P75839 http://phylomedb.org/?seqid=P75839 ProteinModelPortal P75839 http://www.proteinmodelportal.org/query/uniprot/P75839 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415426 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415426 RefSeq WP_000642849 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000642849 STRING 511145.b0906 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0906&targetmode=cogs UniProtKB YCAP_ECOLI http://www.uniprot.org/uniprot/YCAP_ECOLI UniProtKB-AC P75839 http://www.uniprot.org/uniprot/P75839 charge swissprot:YCAP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCAP_ECOLI eggNOG COG2323 http://eggnogapi.embl.de/nog_data/html/tree/COG2323 eggNOG ENOG4107VMU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107VMU epestfind swissprot:YCAP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCAP_ECOLI garnier swissprot:YCAP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCAP_ECOLI helixturnhelix swissprot:YCAP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCAP_ECOLI hmoment swissprot:YCAP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCAP_ECOLI iep swissprot:YCAP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCAP_ECOLI inforesidue swissprot:YCAP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCAP_ECOLI octanol swissprot:YCAP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCAP_ECOLI pepcoil swissprot:YCAP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCAP_ECOLI pepdigest swissprot:YCAP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCAP_ECOLI pepinfo swissprot:YCAP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCAP_ECOLI pepnet swissprot:YCAP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCAP_ECOLI pepstats swissprot:YCAP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCAP_ECOLI pepwheel swissprot:YCAP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCAP_ECOLI pepwindow swissprot:YCAP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCAP_ECOLI sigcleave swissprot:YCAP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCAP_ECOLI ## Database ID URL or Descriptions # EcoGene EG14491 yshB # INDUCTION In stationary phase (at protein level). {ECO:0000269|PubMed 19121005}. # Organism YSHB_ECOLI Escherichia coli (strain K12) # PATRIC 32123237 VBIEscCol129921_3979 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YSHB_ECOLI Uncharacterized protein YshB # RefSeq WP_000893994 NZ_LN832404.1 # RefSeq YP_002791260 NC_000913.3 # eggNOG ENOG4106FIY Bacteria # eggNOG ENOG410XVNE LUCA BLAST swissprot:YSHB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YSHB_ECOLI BioCyc EcoCyc:MONOMER0-2884 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2884 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2008.06495.x http://dx.doi.org/10.1111/j.1365-2958.2008.06495.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14491 http://www.ecogene.org/geneInfo.php?eg_id=EG14491 EnsemblBacteria ACO60012 http://www.ensemblgenomes.org/id/ACO60012 EnsemblBacteria ACO60012 http://www.ensemblgenomes.org/id/ACO60012 EnsemblBacteria b4686 http://www.ensemblgenomes.org/id/b4686 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 7751621 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7751621 HOGENOM HOG000009653 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009653&db=HOGENOM6 KEGG_Gene eco:b4686 http://www.genome.jp/dbget-bin/www_bget?eco:b4686 PSORT swissprot:YSHB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YSHB_ECOLI PSORT-B swissprot:YSHB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YSHB_ECOLI PSORT2 swissprot:YSHB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YSHB_ECOLI Phobius swissprot:YSHB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YSHB_ECOLI PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19121005 http://www.ncbi.nlm.nih.gov/pubmed/19121005 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000893994 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000893994 RefSeq YP_002791260 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_002791260 STRING 511145.b4686 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4686&targetmode=cogs UniProtKB YSHB_ECOLI http://www.uniprot.org/uniprot/YSHB_ECOLI UniProtKB-AC C1P620 http://www.uniprot.org/uniprot/C1P620 charge swissprot:YSHB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YSHB_ECOLI eggNOG ENOG4106FIY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106FIY eggNOG ENOG410XVNE http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XVNE epestfind swissprot:YSHB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YSHB_ECOLI garnier swissprot:YSHB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YSHB_ECOLI helixturnhelix swissprot:YSHB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YSHB_ECOLI hmoment swissprot:YSHB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YSHB_ECOLI iep swissprot:YSHB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YSHB_ECOLI inforesidue swissprot:YSHB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YSHB_ECOLI octanol swissprot:YSHB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YSHB_ECOLI pepcoil swissprot:YSHB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YSHB_ECOLI pepdigest swissprot:YSHB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YSHB_ECOLI pepinfo swissprot:YSHB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YSHB_ECOLI pepnet swissprot:YSHB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YSHB_ECOLI pepstats swissprot:YSHB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YSHB_ECOLI pepwheel swissprot:YSHB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YSHB_ECOLI pepwindow swissprot:YSHB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YSHB_ECOLI sigcleave swissprot:YSHB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YSHB_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES PUUP_ECOLI Kinetic parameters KM=3.7 uM for putrescine {ECO 0000269|PubMed 19181795}; Vmax=19.9 nmol/min/mg enzyme {ECO 0000269|PubMed 19181795}; # BioGrid 4260139 3 # EcoGene EG13907 puuP # FUNCTION PUUP_ECOLI Involved in the uptake of putrescine. {ECO 0000269|PubMed 15590624, ECO 0000269|PubMed 19181795}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0015179 L-amino acid transmembrane transporter activity; IBA:GO_Central. # GO_function GO:0015297 antiporter activity; IBA:GO_Central. # GO_function GO:0015489 putrescine transmembrane transporter activity; EXP:EcoCyc. # GO_function PUUP_ECOLI GO 0015295 solute proton symporter activity; IDA EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0009447 putrescine catabolic process; IMP:EcoCyc. # GO_process GO:0015847 putrescine transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # INDUCTION Repressed by PuuR. {ECO:0000269|PubMed 19181795}. # IntAct P76037 2 # InterPro IPR002293 AA/rel_permease1 # InterPro IPR004841 AA-permease/SLC12A_dom # KEGG_Brite ko02000 Transporters # Organism PUUP_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11785 PTHR11785 # PATHWAY PUUP_ECOLI Amine and polyamine degradation; putrescine degradation. # PATRIC 32117862 VBIEscCol129921_1351 # PIR C64878 C64878 # PIRSF PIRSF006060 AA_transporter # Pfam PF00324 AA_permease # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PUUP_ECOLI Putrescine importer PuuP # RefSeq NP_415812 NC_000913.3 # SIMILARITY Belongs to the amino acid-polyamine-organocation (APC) superfamily. {ECO 0000305}. # SUBCELLULAR LOCATION PUUP_ECOLI Cell inner membrane {ECO 0000305}; Multi- pass membrane protein {ECO 0000305}. # TCDB 2.A.3.1.13 the amino acid-polyamine-organocation (apc) family # eggNOG COG0531 LUCA # eggNOG ENOG4105CUB Bacteria BLAST swissprot:PUUP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PUUP_ECOLI BioCyc ECOL316407:JW1289-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1289-MONOMER BioCyc EcoCyc:B1296-MONOMER http://biocyc.org/getid?id=EcoCyc:B1296-MONOMER BioCyc MetaCyc:B1296-MONOMER http://biocyc.org/getid?id=MetaCyc:B1296-MONOMER COG COG0531 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0531 DIP DIP-11601N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11601N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M411114200 http://dx.doi.org/10.1074/jbc.M411114200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01314-08 http://dx.doi.org/10.1128/JB.01314-08 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3666 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3666 EcoGene EG13907 http://www.ecogene.org/geneInfo.php?eg_id=EG13907 EnsemblBacteria AAC74378 http://www.ensemblgenomes.org/id/AAC74378 EnsemblBacteria AAC74378 http://www.ensemblgenomes.org/id/AAC74378 EnsemblBacteria BAA14856 http://www.ensemblgenomes.org/id/BAA14856 EnsemblBacteria BAA14856 http://www.ensemblgenomes.org/id/BAA14856 EnsemblBacteria BAA14856 http://www.ensemblgenomes.org/id/BAA14856 EnsemblBacteria b1296 http://www.ensemblgenomes.org/id/b1296 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015179 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015179 GO_function GO:0015295 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015295 GO_function GO:0015297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015297 GO_function GO:0015489 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015489 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0009447 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009447 GO_process GO:0015847 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015847 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 946287 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946287 HOGENOM HOG000164060 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000164060&db=HOGENOM6 InParanoid P76037 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76037 IntAct P76037 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76037* InterPro IPR002293 http://www.ebi.ac.uk/interpro/entry/IPR002293 InterPro IPR004841 http://www.ebi.ac.uk/interpro/entry/IPR004841 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1289 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1289 KEGG_Gene eco:b1296 http://www.genome.jp/dbget-bin/www_bget?eco:b1296 KEGG_Orthology KO:K14052 http://www.genome.jp/dbget-bin/www_bget?KO:K14052 MINT MINT-1252906 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1252906 OMA CGAACIG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CGAACIG PANTHER PTHR11785 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11785 PSORT swissprot:PUUP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PUUP_ECOLI PSORT-B swissprot:PUUP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PUUP_ECOLI PSORT2 swissprot:PUUP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PUUP_ECOLI Pfam PF00324 http://pfam.xfam.org/family/PF00324 Phobius swissprot:PUUP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PUUP_ECOLI PhylomeDB P76037 http://phylomedb.org/?seqid=P76037 ProteinModelPortal P76037 http://www.proteinmodelportal.org/query/uniprot/P76037 PubMed 15590624 http://www.ncbi.nlm.nih.gov/pubmed/15590624 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19181795 http://www.ncbi.nlm.nih.gov/pubmed/19181795 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415812 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415812 STRING 511145.b1296 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1296&targetmode=cogs STRING COG0531 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0531&targetmode=cogs TCDB 2.A.3.1.13 http://www.tcdb.org/search/result.php?tc=2.A.3.1.13 UniProtKB PUUP_ECOLI http://www.uniprot.org/uniprot/PUUP_ECOLI UniProtKB-AC P76037 http://www.uniprot.org/uniprot/P76037 charge swissprot:PUUP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PUUP_ECOLI eggNOG COG0531 http://eggnogapi.embl.de/nog_data/html/tree/COG0531 eggNOG ENOG4105CUB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CUB epestfind swissprot:PUUP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PUUP_ECOLI garnier swissprot:PUUP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PUUP_ECOLI helixturnhelix swissprot:PUUP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PUUP_ECOLI hmoment swissprot:PUUP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PUUP_ECOLI iep swissprot:PUUP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PUUP_ECOLI inforesidue swissprot:PUUP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PUUP_ECOLI octanol swissprot:PUUP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PUUP_ECOLI pepcoil swissprot:PUUP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PUUP_ECOLI pepdigest swissprot:PUUP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PUUP_ECOLI pepinfo swissprot:PUUP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PUUP_ECOLI pepnet swissprot:PUUP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PUUP_ECOLI pepstats swissprot:PUUP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PUUP_ECOLI pepwheel swissprot:PUUP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PUUP_ECOLI pepwindow swissprot:PUUP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PUUP_ECOLI sigcleave swissprot:PUUP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PUUP_ECOLI ## Database ID URL or Descriptions # AltName CHIP_ECOLI ChiP-III # BioGrid 4261649 315 # EcoGene EG13659 chiP # FUNCTION CHIP_ECOLI Involved in the uptake of chitosugars. {ECO 0000305|PubMed 16857666, ECO 0000305|PubMed 19682266}. # GO_component GO:0009279 cell outer membrane; IEA:UniProtKB-SubCell. # GO_component GO:0046930 pore complex; IEA:UniProtKB-KW. # GO_function GO:0015288 porin activity; IEA:UniProtKB-KW. # GO_process GO:0006811 ion transport; IEA:UniProtKB-KW. # GO_process GO:0015774 polysaccharide transport; IEA:UniProtKB-KW. # GO_process GO:0052778 diacetylchitobiose metabolic process; IEP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043234 protein complex # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # Gene3D 2.40.160.10 -; 1. # INDUCTION CHIP_ECOLI In the absence of chitobiose, expression of chiPQ is silenced by the MicM small regulatory RNA (sRNA), which sequesters the ribosome binding site of the chiPQ mRNA by an antisense mechanism. In the presence of chitosugars, the chbBCARFG chitobiose operon is induced and acts as an RNA trap to degrade the constitutively expressed MicM, leading to the translation of chiPQ. {ECO 0000269|PubMed 19400782, ECO 0000269|PubMed 19682266}. # InterPro IPR005318 OM_porin_bac # InterPro IPR023614 Porin_dom # Organism CHIP_ECOLI Escherichia coli (strain K12) # PATRIC 32116555 VBIEscCol129921_0710 # PIR H64802 H64802 # Pfam PF03573 OprD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CHIP_ECOLI Chitoporin # RefSeq NP_415207 NC_000913.3 # RefSeq WP_001258819 NZ_LN832404.1 # SIMILARITY Belongs to the outer membrane porin (Opr) (TC 1.B.25) family. {ECO 0000305}. # SUBCELLULAR LOCATION CHIP_ECOLI Cell outer membrane {ECO 0000305|PubMed 12192075}; Multi-pass membrane protein {ECO 0000305|PubMed 12192075}. # TCDB 1.B.25.1.13 the outer membrane porin (opr) family BLAST swissprot:CHIP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CHIP_ECOLI BioCyc ECOL316407:JW0667-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0667-MONOMER BioCyc EcoCyc:G6370-MONOMER http://biocyc.org/getid?id=EcoCyc:G6370-MONOMER BioCyc MetaCyc:G6370-MONOMER http://biocyc.org/getid?id=MetaCyc:G6370-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M605052200 http://dx.doi.org/10.1074/jbc.M605052200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1110/ps.0209002 http://dx.doi.org/10.1110/ps.0209002 DOI 10.1111/j.1365-2958.2009.06688.x http://dx.doi.org/10.1111/j.1365-2958.2009.06688.x DOI 10.1111/j.1365-2958.2009.06807.x http://dx.doi.org/10.1111/j.1365-2958.2009.06807.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3423 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3423 EcoGene EG13659 http://www.ecogene.org/geneInfo.php?eg_id=EG13659 EnsemblBacteria AAC73775 http://www.ensemblgenomes.org/id/AAC73775 EnsemblBacteria AAC73775 http://www.ensemblgenomes.org/id/AAC73775 EnsemblBacteria BAA35329 http://www.ensemblgenomes.org/id/BAA35329 EnsemblBacteria BAA35329 http://www.ensemblgenomes.org/id/BAA35329 EnsemblBacteria BAA35329 http://www.ensemblgenomes.org/id/BAA35329 EnsemblBacteria b0681 http://www.ensemblgenomes.org/id/b0681 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0046930 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046930 GO_function GO:0015288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015288 GO_process GO:0006811 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811 GO_process GO:0015774 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015774 GO_process GO:0052778 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052778 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 2.40.160.10 http://www.cathdb.info/version/latest/superfamily/2.40.160.10 GeneID 945296 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945296 HOGENOM HOG000273273 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000273273&db=HOGENOM6 InParanoid P75733 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75733 InterPro IPR005318 http://www.ebi.ac.uk/interpro/entry/IPR005318 InterPro IPR023614 http://www.ebi.ac.uk/interpro/entry/IPR023614 KEGG_Gene ecj:JW0667 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0667 KEGG_Gene eco:b0681 http://www.genome.jp/dbget-bin/www_bget?eco:b0681 OMA TWVKAEG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TWVKAEG PSORT swissprot:CHIP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CHIP_ECOLI PSORT-B swissprot:CHIP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CHIP_ECOLI PSORT2 swissprot:CHIP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CHIP_ECOLI Pfam PF03573 http://pfam.xfam.org/family/PF03573 Phobius swissprot:CHIP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CHIP_ECOLI PhylomeDB P75733 http://phylomedb.org/?seqid=P75733 ProteinModelPortal P75733 http://www.proteinmodelportal.org/query/uniprot/P75733 PubMed 12192075 http://www.ncbi.nlm.nih.gov/pubmed/12192075 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16857666 http://www.ncbi.nlm.nih.gov/pubmed/16857666 PubMed 19400782 http://www.ncbi.nlm.nih.gov/pubmed/19400782 PubMed 19682266 http://www.ncbi.nlm.nih.gov/pubmed/19682266 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415207 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415207 RefSeq WP_001258819 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001258819 STRING 511145.b0681 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0681&targetmode=cogs TCDB 1.B.25.1.13 http://www.tcdb.org/search/result.php?tc=1.B.25.1.13 UniProtKB CHIP_ECOLI http://www.uniprot.org/uniprot/CHIP_ECOLI UniProtKB-AC P75733 http://www.uniprot.org/uniprot/P75733 charge swissprot:CHIP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CHIP_ECOLI epestfind swissprot:CHIP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CHIP_ECOLI garnier swissprot:CHIP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CHIP_ECOLI helixturnhelix swissprot:CHIP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CHIP_ECOLI hmoment swissprot:CHIP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CHIP_ECOLI iep swissprot:CHIP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CHIP_ECOLI inforesidue swissprot:CHIP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CHIP_ECOLI octanol swissprot:CHIP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CHIP_ECOLI pepcoil swissprot:CHIP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CHIP_ECOLI pepdigest swissprot:CHIP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CHIP_ECOLI pepinfo swissprot:CHIP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CHIP_ECOLI pepnet swissprot:CHIP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CHIP_ECOLI pepstats swissprot:CHIP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CHIP_ECOLI pepwheel swissprot:CHIP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CHIP_ECOLI pepwindow swissprot:CHIP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CHIP_ECOLI sigcleave swissprot:CHIP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CHIP_ECOLI ## Database ID URL or Descriptions # BioGrid 4259958 8 # EcoGene EG13667 ybhK # FUNCTION GNGF_ECOLI Required for morphogenesis under gluconeogenic growth conditions. {ECO 0000305}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_process GO:0008360 regulation of cell shape; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005737 cytoplasm # GOslim_process GO:0008150 biological_process # HAMAP MF_00973 Gluconeogen_factor # INTERACTION GNGF_ECOLI P0AEW6 gsk; NbExp=4; IntAct=EBI-550390, EBI-548746; # IntAct P75767 44 # InterPro IPR002882 CofD/UPF0052 # InterPro IPR010119 Gluconeogen_factor # MISCELLANEOUS Was shown to partially rescue a mgfK mutant in B.subtilis, suggesting that the function of this protein is conserved in different bacteria. {ECO:0000305|PubMed 16272399}. # Organism GNGF_ECOLI Escherichia coli (strain K12) # PATRIC 32116761 VBIEscCol129921_0806 # PIR D64814 D64814 # Pfam PF01933 UPF0052 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Putative gluconeogenesis factor {ECO:0000255|HAMAP-Rule MF_00973} # RefSeq NP_415301 NC_000913.3 # RefSeq WP_001295302 NZ_LN832404.1 # SIMILARITY Belongs to the gluconeogenesis factor family. {ECO:0000255|HAMAP-Rule MF_00973}. # SUBCELLULAR LOCATION GNGF_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00973}. # TIGRFAMs TIGR01826 CofD_related # eggNOG COG0391 LUCA # eggNOG ENOG4105CHW Bacteria BLAST swissprot:GNGF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GNGF_ECOLI BioCyc ECOL316407:JW0763-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0763-MONOMER BioCyc EcoCyc:G6402-MONOMER http://biocyc.org/getid?id=EcoCyc:G6402-MONOMER DIP DIP-11414N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11414N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1099/mic.0.28172-0 http://dx.doi.org/10.1099/mic.0.28172-0 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3431 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3431 EcoGene EG13667 http://www.ecogene.org/geneInfo.php?eg_id=EG13667 EnsemblBacteria AAC73867 http://www.ensemblgenomes.org/id/AAC73867 EnsemblBacteria AAC73867 http://www.ensemblgenomes.org/id/AAC73867 EnsemblBacteria BAA35438 http://www.ensemblgenomes.org/id/BAA35438 EnsemblBacteria BAA35438 http://www.ensemblgenomes.org/id/BAA35438 EnsemblBacteria BAA35438 http://www.ensemblgenomes.org/id/BAA35438 EnsemblBacteria b0780 http://www.ensemblgenomes.org/id/b0780 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 945390 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945390 HAMAP MF_00973 http://hamap.expasy.org/unirule/MF_00973 HOGENOM HOG000072686 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000072686&db=HOGENOM6 InParanoid P75767 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75767 IntAct P75767 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75767* InterPro IPR002882 http://www.ebi.ac.uk/interpro/entry/IPR002882 InterPro IPR010119 http://www.ebi.ac.uk/interpro/entry/IPR010119 KEGG_Gene ecj:JW0763 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0763 KEGG_Gene eco:b0780 http://www.genome.jp/dbget-bin/www_bget?eco:b0780 MINT MINT-1218734 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1218734 OMA LCVRPLD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LCVRPLD PSORT swissprot:GNGF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GNGF_ECOLI PSORT-B swissprot:GNGF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GNGF_ECOLI PSORT2 swissprot:GNGF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GNGF_ECOLI Pfam PF01933 http://pfam.xfam.org/family/PF01933 Phobius swissprot:GNGF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GNGF_ECOLI PhylomeDB P75767 http://phylomedb.org/?seqid=P75767 ProteinModelPortal P75767 http://www.proteinmodelportal.org/query/uniprot/P75767 PubMed 16272399 http://www.ncbi.nlm.nih.gov/pubmed/16272399 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415301 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415301 RefSeq WP_001295302 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295302 SMR P75767 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75767 STRING 511145.b0780 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0780&targetmode=cogs TIGRFAMs TIGR01826 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01826 UniProtKB GNGF_ECOLI http://www.uniprot.org/uniprot/GNGF_ECOLI UniProtKB-AC P75767 http://www.uniprot.org/uniprot/P75767 charge swissprot:GNGF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GNGF_ECOLI eggNOG COG0391 http://eggnogapi.embl.de/nog_data/html/tree/COG0391 eggNOG ENOG4105CHW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CHW epestfind swissprot:GNGF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GNGF_ECOLI garnier swissprot:GNGF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GNGF_ECOLI helixturnhelix swissprot:GNGF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GNGF_ECOLI hmoment swissprot:GNGF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GNGF_ECOLI iep swissprot:GNGF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GNGF_ECOLI inforesidue swissprot:GNGF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GNGF_ECOLI octanol swissprot:GNGF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GNGF_ECOLI pepcoil swissprot:GNGF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GNGF_ECOLI pepdigest swissprot:GNGF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GNGF_ECOLI pepinfo swissprot:GNGF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GNGF_ECOLI pepnet swissprot:GNGF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GNGF_ECOLI pepstats swissprot:GNGF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GNGF_ECOLI pepwheel swissprot:GNGF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GNGF_ECOLI pepwindow swissprot:GNGF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GNGF_ECOLI sigcleave swissprot:GNGF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GNGF_ECOLI ## Database ID URL or Descriptions # BioGrid 4262249 16 # EcoGene EG13172 yqcC # GO_process GO:0044010 single-species biofilm formation; IMP:EcoCyc. # GOslim_process GO:0008150 biological_process # Gene3D 1.20.1440.40 -; 1. # InterPro IPR007384 UCP006257 # InterPro IPR023376 YqcC-like_dom # Organism YQCC_ECOLI Escherichia coli (strain K12) # PATRIC 32121000 VBIEscCol129921_2892 # PDB 2HGK NMR; -; A=1-109 # PIR D65061 D65061 # PIRSF PIRSF006257 UCP006257 # Pfam PF04287 DUF446 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQCC_ECOLI Uncharacterized protein YqcC # RefSeq NP_417272 NC_000913.3 # RefSeq WP_000206990 NZ_LN832404.1 # SIMILARITY To H.influenzae HI_1436. {ECO 0000305}. # SIMILARITY To the N-terminal of E.carotovora exoenzyme regulation regulon ORF1. The C-terminal part is colinear with YqcB. {ECO 0000305}. # SUPFAM SSF158452 SSF158452 # eggNOG COG3098 LUCA # eggNOG ENOG4105WP7 Bacteria BLAST swissprot:YQCC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQCC_ECOLI BioCyc ECOL316407:JW2763-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2763-MONOMER BioCyc EcoCyc:G7450-MONOMER http://biocyc.org/getid?id=EcoCyc:G7450-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 EchoBASE EB2964 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2964 EcoGene EG13172 http://www.ecogene.org/geneInfo.php?eg_id=EG13172 EnsemblBacteria AAC75834 http://www.ensemblgenomes.org/id/AAC75834 EnsemblBacteria AAC75834 http://www.ensemblgenomes.org/id/AAC75834 EnsemblBacteria BAE76864 http://www.ensemblgenomes.org/id/BAE76864 EnsemblBacteria BAE76864 http://www.ensemblgenomes.org/id/BAE76864 EnsemblBacteria BAE76864 http://www.ensemblgenomes.org/id/BAE76864 EnsemblBacteria b2792 http://www.ensemblgenomes.org/id/b2792 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0044010 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044010 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.20.1440.40 http://www.cathdb.info/version/latest/superfamily/1.20.1440.40 GeneID 946027 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946027 HOGENOM HOG000273810 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000273810&db=HOGENOM6 InParanoid Q46919 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46919 IntAct Q46919 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46919* InterPro IPR007384 http://www.ebi.ac.uk/interpro/entry/IPR007384 InterPro IPR023376 http://www.ebi.ac.uk/interpro/entry/IPR023376 KEGG_Gene ecj:JW2763 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2763 KEGG_Gene eco:b2792 http://www.genome.jp/dbget-bin/www_bget?eco:b2792 OMA MNTENQV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MNTENQV PDB 2HGK http://www.ebi.ac.uk/pdbe-srv/view/entry/2HGK PDBsum 2HGK http://www.ebi.ac.uk/pdbsum/2HGK PSORT swissprot:YQCC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQCC_ECOLI PSORT-B swissprot:YQCC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQCC_ECOLI PSORT2 swissprot:YQCC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQCC_ECOLI Pfam PF04287 http://pfam.xfam.org/family/PF04287 Phobius swissprot:YQCC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQCC_ECOLI ProteinModelPortal Q46919 http://www.proteinmodelportal.org/query/uniprot/Q46919 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417272 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417272 RefSeq WP_000206990 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000206990 SMR Q46919 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46919 STRING 511145.b2792 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2792&targetmode=cogs SUPFAM SSF158452 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF158452 UniProtKB YQCC_ECOLI http://www.uniprot.org/uniprot/YQCC_ECOLI UniProtKB-AC Q46919 http://www.uniprot.org/uniprot/Q46919 charge swissprot:YQCC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQCC_ECOLI eggNOG COG3098 http://eggnogapi.embl.de/nog_data/html/tree/COG3098 eggNOG ENOG4105WP7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105WP7 epestfind swissprot:YQCC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQCC_ECOLI garnier swissprot:YQCC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQCC_ECOLI helixturnhelix swissprot:YQCC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQCC_ECOLI hmoment swissprot:YQCC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQCC_ECOLI iep swissprot:YQCC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQCC_ECOLI inforesidue swissprot:YQCC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQCC_ECOLI octanol swissprot:YQCC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQCC_ECOLI pepcoil swissprot:YQCC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQCC_ECOLI pepdigest swissprot:YQCC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQCC_ECOLI pepinfo swissprot:YQCC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQCC_ECOLI pepnet swissprot:YQCC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQCC_ECOLI pepstats swissprot:YQCC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQCC_ECOLI pepwheel swissprot:YQCC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQCC_ECOLI pepwindow swissprot:YQCC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQCC_ECOLI sigcleave swissprot:YQCC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQCC_ECOLI ## Database ID URL or Descriptions # AltName Putrescine-proton symporter / putrescine-ornithine antiporter {ECO:0000255|HAMAP-Rule MF_02073, ECO:0000305} # BIOPHYSICOCHEMICAL PROPERTIES POTE_ECOLI Kinetic parameters KM=1.8 uM for putrescine (for uptake activity) {ECO 0000269|PubMed 9045651}; KM=73 uM for putrescine (for antiporter activity) {ECO 0000269|PubMed 1584788, ECO 0000269|PubMed 9045651}; KM=108 uM for ornithine (for antiporter activity) {ECO 0000269|PubMed 9045651}; Vmax=0.82 nmol/min/mg enzyme for antiporter activity {ECO 0000269|PubMed 1584788}; pH dependence Optimum pH is 6.5 for uptake activity. Optimum pH is 9.2 for antiporter activity. {ECO 0000269|PubMed 9045651}; # BioGrid 4261131 12 # ENZYME REGULATION POTE_ECOLI Uptake activity, but not antiporter activity, is inhibited by CCCP and N-ethylmaleimide (NEM). Uptake of putrescine is inhibited by high concentrations of ornithine. {ECO 0000269|PubMed 1584788, ECO 0000269|PubMed 9045651}. # EcoGene EG10753 potE # FUNCTION POTE_ECOLI Catalyzes both the uptake and excretion of putrescine. The uptake of putrescine is dependent on the membrane potential and the excretion involves putrescine-ornithine antiporter activity. {ECO 0000255|HAMAP-Rule MF_02073, ECO 0000269|PubMed 1584788, ECO 0000269|PubMed 9045651}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0015293 symporter activity; IDA:EcoCyc. # GO_function POTE_ECOLI GO 0015496 putrescine ornithine antiporter activity; IDA EcoCyc. # GO_process GO:0015822 ornithine transport; IEA:InterPro. # GO_process GO:0015847 putrescine transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # HAMAP MF_02073 Putrescine_transp # InterPro IPR002293 AA/rel_permease1 # InterPro IPR004754 Amino_acid_antiprt # InterPro IPR027566 Antiport_PotE # KEGG_Brite ko02000 Transporters # Organism POTE_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11785 PTHR11785 # PATRIC 32116579 VBIEscCol129921_0722 # PIR B40839 B40839 # PIRSF PIRSF006060 AA_transporter # Pfam PF13520 AA_permease_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Putrescine transporter PotE {ECO:0000255|HAMAP-Rule MF_02073, ECO:0000305} # RefSeq NP_415219 NC_000913.3 # RefSeq WP_000075845 NZ_LN832404.1 # SIMILARITY Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family. {ECO:0000255|HAMAP-Rule MF_02073, ECO:0000305}. # SUBCELLULAR LOCATION POTE_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_02073, ECO 0000269|PubMed 9045651}; Multi-pass membrane protein {ECO 0000255|HAMAP-Rule MF_02073}. # SUBUNIT Monomer. {ECO:0000269|PubMed 10964926}. # TCDB 2.A.3.2 the amino acid-polyamine-organocation (apc) family # TIGRFAMs TIGR00905 2A0302 # TIGRFAMs TIGR04299 antiport_PotE # eggNOG COG0531 LUCA # eggNOG ENOG4105D5Q Bacteria BLAST swissprot:POTE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:POTE_ECOLI BioCyc ECOL316407:JW0679-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0679-MONOMER BioCyc EcoCyc:POTE-MONOMER http://biocyc.org/getid?id=EcoCyc:POTE-MONOMER BioCyc MetaCyc:POTE-MONOMER http://biocyc.org/getid?id=MetaCyc:POTE-MONOMER COG COG0531 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0531 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.89.10.4529 http://dx.doi.org/10.1073/pnas.89.10.4529 DOI 10.1074/jbc.272.10.6318 http://dx.doi.org/10.1074/jbc.272.10.6318 DOI 10.1074/jbc.M006083200 http://dx.doi.org/10.1074/jbc.M006083200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M64495 http://www.ebi.ac.uk/ena/data/view/M64495 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0746 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0746 EcoGene EG10753 http://www.ecogene.org/geneInfo.php?eg_id=EG10753 EnsemblBacteria AAC73786 http://www.ensemblgenomes.org/id/AAC73786 EnsemblBacteria AAC73786 http://www.ensemblgenomes.org/id/AAC73786 EnsemblBacteria BAA35348 http://www.ensemblgenomes.org/id/BAA35348 EnsemblBacteria BAA35348 http://www.ensemblgenomes.org/id/BAA35348 EnsemblBacteria BAA35348 http://www.ensemblgenomes.org/id/BAA35348 EnsemblBacteria b0692 http://www.ensemblgenomes.org/id/b0692 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015293 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293 GO_function GO:0015496 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015496 GO_process GO:0015822 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015822 GO_process GO:0015847 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015847 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 945422 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945422 HAMAP MF_02073 http://hamap.expasy.org/unirule/MF_02073 HOGENOM HOG000164507 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000164507&db=HOGENOM6 InParanoid P0AAF1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAF1 IntAct P0AAF1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAF1* InterPro IPR002293 http://www.ebi.ac.uk/interpro/entry/IPR002293 InterPro IPR004754 http://www.ebi.ac.uk/interpro/entry/IPR004754 InterPro IPR027566 http://www.ebi.ac.uk/interpro/entry/IPR027566 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0679 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0679 KEGG_Gene eco:b0692 http://www.genome.jp/dbget-bin/www_bget?eco:b0692 KEGG_Orthology KO:K03756 http://www.genome.jp/dbget-bin/www_bget?KO:K03756 OMA KHEPLAN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KHEPLAN PANTHER PTHR11785 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11785 PSORT swissprot:POTE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:POTE_ECOLI PSORT-B swissprot:POTE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:POTE_ECOLI PSORT2 swissprot:POTE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:POTE_ECOLI Pfam PF13520 http://pfam.xfam.org/family/PF13520 Phobius swissprot:POTE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:POTE_ECOLI PhylomeDB P0AAF1 http://phylomedb.org/?seqid=P0AAF1 ProteinModelPortal P0AAF1 http://www.proteinmodelportal.org/query/uniprot/P0AAF1 PubMed 10964926 http://www.ncbi.nlm.nih.gov/pubmed/10964926 PubMed 1584788 http://www.ncbi.nlm.nih.gov/pubmed/1584788 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1939141 http://www.ncbi.nlm.nih.gov/pubmed/1939141 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9045651 http://www.ncbi.nlm.nih.gov/pubmed/9045651 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415219 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415219 RefSeq WP_000075845 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000075845 STRING 511145.b0692 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0692&targetmode=cogs STRING COG0531 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0531&targetmode=cogs TCDB 2.A.3.2 http://www.tcdb.org/search/result.php?tc=2.A.3.2 TIGRFAMs TIGR00905 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00905 TIGRFAMs TIGR04299 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR04299 UniProtKB POTE_ECOLI http://www.uniprot.org/uniprot/POTE_ECOLI UniProtKB-AC P0AAF1 http://www.uniprot.org/uniprot/P0AAF1 charge swissprot:POTE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:POTE_ECOLI eggNOG COG0531 http://eggnogapi.embl.de/nog_data/html/tree/COG0531 eggNOG ENOG4105D5Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D5Q epestfind swissprot:POTE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:POTE_ECOLI garnier swissprot:POTE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:POTE_ECOLI helixturnhelix swissprot:POTE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:POTE_ECOLI hmoment swissprot:POTE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:POTE_ECOLI iep swissprot:POTE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:POTE_ECOLI inforesidue swissprot:POTE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:POTE_ECOLI octanol swissprot:POTE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:POTE_ECOLI pepcoil swissprot:POTE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:POTE_ECOLI pepdigest swissprot:POTE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:POTE_ECOLI pepinfo swissprot:POTE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:POTE_ECOLI pepnet swissprot:POTE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:POTE_ECOLI pepstats swissprot:POTE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:POTE_ECOLI pepwheel swissprot:POTE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:POTE_ECOLI pepwindow swissprot:POTE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:POTE_ECOLI sigcleave swissprot:POTE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:POTE_ECOLI ## Database ID URL or Descriptions # BioGrid 4262516 11 # CAUTION Could be the product of a pseudogene. A frameshift in position 399 produces two separate ORFs. {ECO 0000305}. # EcoGene EG12227 yhiL # IntAct P37629 13 # InterPro IPR025123 DUF4049 # InterPro IPR029052 Metallo-depent_PP-like # Organism YHIL_ECOLI Escherichia coli (strain K12) # PATRIC 48667120 VBIEscCol107702_3825 # PIR E65146 E65146 # PIR S47709 S47709 # Pfam PF13258 DUF4049 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHIL_ECOLI Putative uncharacterized protein YhiL # SEQUENCE CAUTION YHIL_ECOLI Sequence=AAB18465.1; Type=Frameshift; Positions=399; Evidence={ECO 0000305}; Sequence=AAB18466.1; Type=Frameshift; Positions=399; Evidence={ECO 0000305}; Sequence=BAE77804.1; Type=Frameshift; Positions=399; Evidence={ECO 0000305}; Sequence=U00096; Type=Frameshift; Positions=399; Evidence={ECO 0000305}; # SUPFAM SSF56300 SSF56300 BLAST swissprot:YHIL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHIL_ECOLI BioCyc ECOL316407:JW3457-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3457-MONOMER BioCyc EcoCyc:EG12226-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12226-MONOMER BioCyc EcoCyc:EG12227-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12227-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2139 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2139 EcoGene EG12227 http://www.ecogene.org/geneInfo.php?eg_id=EG12227 EnsemblBacteria BAE77804 http://www.ensemblgenomes.org/id/BAE77804 EnsemblBacteria BAE77804 http://www.ensemblgenomes.org/id/BAE77804 EnsemblBacteria BAE77804 http://www.ensemblgenomes.org/id/BAE77804 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv HOGENOM HOG000009622 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009622&db=HOGENOM6 IntAct P37629 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37629* InterPro IPR025123 http://www.ebi.ac.uk/interpro/entry/IPR025123 InterPro IPR029052 http://www.ebi.ac.uk/interpro/entry/IPR029052 KEGG_Gene ecj:JW3457 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3457 OMA HMDDRLI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HMDDRLI PSORT swissprot:YHIL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHIL_ECOLI PSORT-B swissprot:YHIL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHIL_ECOLI PSORT2 swissprot:YHIL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHIL_ECOLI Pfam PF13258 http://pfam.xfam.org/family/PF13258 Phobius swissprot:YHIL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHIL_ECOLI ProteinModelPortal P37629 http://www.proteinmodelportal.org/query/uniprot/P37629 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 STRING 316407.85676554 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85676554&targetmode=cogs SUPFAM SSF56300 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56300 UniProtKB YHIL_ECOLI http://www.uniprot.org/uniprot/YHIL_ECOLI UniProtKB-AC P37629 http://www.uniprot.org/uniprot/P37629 charge swissprot:YHIL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHIL_ECOLI epestfind swissprot:YHIL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHIL_ECOLI garnier swissprot:YHIL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHIL_ECOLI helixturnhelix swissprot:YHIL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHIL_ECOLI hmoment swissprot:YHIL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHIL_ECOLI iep swissprot:YHIL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHIL_ECOLI inforesidue swissprot:YHIL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHIL_ECOLI octanol swissprot:YHIL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHIL_ECOLI pepcoil swissprot:YHIL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHIL_ECOLI pepdigest swissprot:YHIL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHIL_ECOLI pepinfo swissprot:YHIL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHIL_ECOLI pepnet swissprot:YHIL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHIL_ECOLI pepstats swissprot:YHIL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHIL_ECOLI pepwheel swissprot:YHIL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHIL_ECOLI pepwindow swissprot:YHIL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHIL_ECOLI sigcleave swissprot:YHIL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHIL_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES RBSK_ECOLI Kinetic parameters KM=0.213 mM for ATP {ECO 0000269|PubMed 16784868}; KM=0.279 mM for D-ribose {ECO 0000269|PubMed 16784868}; KM=1.41 mM for 2-deoxy-D-ribose {ECO 0000269|PubMed 16784868}; KM=32 mM for D-arabinose {ECO 0000269|PubMed 16784868}; KM=31.6 mM for D-xylose {ECO 0000269|PubMed 16784868}; KM=8.2 mM for D-fructose {ECO 0000269|PubMed 16784868}; KM=0.65 mM for ribose (at pH 6.2 in the presence of 0 mM inorganic phosphate) {ECO 0000269|PubMed 11563694}; KM=0.43 mM for ribose (at pH 6.2 in the presence of 0.5 mM inorganic phosphate) {ECO 0000269|PubMed 11563694}; KM=0.27 mM for ribose (at pH 6.2 in the presence of 1 mM inorganic phosphate) {ECO 0000269|PubMed 11563694}; KM=0.23 mM for ribose (at pH 6.2 in the presence of 5 mM inorganic phosphate) {ECO 0000269|PubMed 11563694}; KM=0.21 mM for ribose (at pH 6.2 in the presence of 20 mM inorganic phosphate) {ECO 0000269|PubMed 11563694}; Vmax=122 umol/min/mg enzyme toward ATP {ECO 0000269|PubMed 16784868}; Vmax=81 umol/min/mg enzyme toward D-ribose {ECO 0000269|PubMed 16784868}; Vmax=25 umol/min/mg enzyme toward 2-deoxy-D-ribose {ECO 0000269|PubMed 16784868}; Vmax=0.6 umol/min/mg enzyme toward D-arabinose {ECO 0000269|PubMed 16784868}; Vmax=0.86 umol/min/mg enzyme toward D-xylose {ECO 0000269|PubMed 16784868}; Vmax=0.226 umol/min/mg enzyme toward D-fructose {ECO 0000269|PubMed 16784868}; Vmax=7.6 pmol/min/mg enzyme (at pH 6.2 in the presence of 0 mM inorganic phosphate) {ECO 0000269|PubMed 11563694}; Vmax=32.0 pmol/min/mg enzyme (at pH 6.2 in the presence of 0.5 mM inorganic phosphate) {ECO 0000269|PubMed 11563694}; Vmax=59.6 pmol/min/mg enzyme (at pH 6.2 in the presence of 1 mM inorganic phosphate) {ECO 0000269|PubMed 11563694}; Vmax=139.4 pmol/min/mg enzyme (at pH 6.2 in the presence of 5 mM inorganic phosphate) {ECO 0000269|PubMed 11563694}; Vmax=172.4 pmol/min/mg enzyme (at pH 6.2 in the presence of 20 mM inorganic phosphate) {ECO 0000269|PubMed 11563694}; pH dependence Optimum pH is 8-9. {ECO 0000269|PubMed 16784868}; Temperature dependence Optimum temperature is 30-50 degrees Celsius. {ECO 0000269|PubMed 16784868}; # BRENDA 2.7.1.15 2026 # BioGrid 4259582 11 # CATALYTIC ACTIVITY RBSK_ECOLI ATP + D-ribose = ADP + D-ribose 5-phosphate. {ECO 0000255|HAMAP-Rule MF_01987, ECO 0000269|PubMed 11563694, ECO 0000269|PubMed 16784868, ECO 0000269|PubMed 3011794}. # CDD cd01174 ribokinase # COFACTOR RBSK_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_01987, ECO 0000269|PubMed 16784868, ECO 0000305|PubMed 11786021}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 16784868}; Note=Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate (Probable). Also active with manganase (PubMed 16784868). {ECO 0000255|HAMAP-Rule MF_01987, ECO 0000269|PubMed 16784868, ECO 0000305|PubMed 11786021}; # ENZYME REGULATION RBSK_ECOLI Activated by a monovalent cation that binds near, but not in, the active site (PubMed 11786021). The most likely occupant of the site in vivo is potassium (PubMed 16784868, PubMed 11786021). Also activated by ammonium ion (PubMed 16784868). Ion binding induces a conformational change that may alter substrate affinity (Probable). {ECO 0000255|HAMAP- Rule MF_01987, ECO 0000269|PubMed 11786021, ECO 0000269|PubMed 16784868, ECO 0000305|PubMed 11786021}. # EcoGene EG10818 rbsK # FUNCTION RBSK_ECOLI Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. {ECO 0000255|HAMAP-Rule MF_01987, ECO 0000269|PubMed 11563694, ECO 0000269|PubMed 3011794}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004747 ribokinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0019303 D-ribose catabolic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.1190.20 -; 1. # HAMAP MF_01987 Ribokinase # IntAct P0A9J6 3 # InterPro IPR002139 Ribo/fructo_kinase # InterPro IPR002173 Carboh/pur_kinase_PfkB_CS # InterPro IPR011611 PfkB_dom # InterPro IPR011877 D_ribokin # InterPro IPR029056 Ribokinase-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00030 Pentose phosphate pathway # Organism RBSK_ECOLI Escherichia coli (strain K12) # PATHWAY RBSK_ECOLI Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose step 2/2. {ECO 0000255|HAMAP-Rule MF_01987, ECO 0000305|PubMed 3011794}. # PATRIC 32123003 VBIEscCol129921_3877 # PDB 1GQT X-ray; 2.34 A; A/B/C/D=1-309 # PDB 1RK2 X-ray; 2.25 A; A/B/C/D=1-309 # PDB 1RKA X-ray; 2.30 A; A=1-309 # PDB 1RKD X-ray; 1.84 A; A=1-309 # PDB 1RKS X-ray; 2.40 A; A=1-309 # PIR A26305 KIECRB # PRINTS PR00990 RIBOKINASE # PROSITE PS00584 PFKB_KINASES_2 # Pfam PF00294 PfkB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RBSK_ECOLI Ribokinase {ECO 0000255|HAMAP-Rule MF_01987, ECO 0000303|PubMed 3011794} # RefSeq NP_418208 NC_000913.3 # RefSeq WP_001300603 NZ_LN832404.1 # SIMILARITY Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily. {ECO:0000255|HAMAP-Rule MF_01987}. # SUBCELLULAR LOCATION RBSK_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_01987, ECO 0000305}. # SUBUNIT RBSK_ECOLI Homodimer. {ECO 0000255|HAMAP-Rule MF_01987, ECO 0000269|PubMed 9385653}. # SUPFAM SSF53613 SSF53613 # TIGRFAMs TIGR02152 D_ribokin_bact # UniPathway UPA00916 UER00889 # eggNOG COG0524 LUCA # eggNOG ENOG4108RVA Bacteria BLAST swissprot:RBSK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RBSK_ECOLI BioCyc ECOL316407:JW3731-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3731-MONOMER BioCyc EcoCyc:RIBOKIN-MONOMER http://biocyc.org/getid?id=EcoCyc:RIBOKIN-MONOMER BioCyc MetaCyc:RIBOKIN-MONOMER http://biocyc.org/getid?id=MetaCyc:RIBOKIN-MONOMER COG COG0524 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0524 DIP DIP-36178N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36178N DOI 10.1002/pro.5560061124 http://dx.doi.org/10.1002/pro.5560061124 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1006/jmbi.1999.2938 http://dx.doi.org/10.1006/jmbi.1999.2938 DOI 10.1006/jmbi.2001.5248 http://dx.doi.org/10.1006/jmbi.2001.5248 DOI 10.1016/S0969-2126(98)00020-3 http://dx.doi.org/10.1016/S0969-2126(98)00020-3 DOI 10.1016/j.bmc.2006.05.057 http://dx.doi.org/10.1016/j.bmc.2006.05.057 DOI 10.1023/A:1011081508171 http://dx.doi.org/10.1023/A:1011081508171 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.15 {ECO:0000255|HAMAP-Rule:MF_01987, ECO:0000269|PubMed:11563694, ECO:0000269|PubMed:3011794} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.15 {ECO:0000255|HAMAP-Rule:MF_01987, ECO:0000269|PubMed:11563694, ECO:0000269|PubMed:3011794} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M13169 http://www.ebi.ac.uk/ena/data/view/M13169 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.15 {ECO:0000255|HAMAP-Rule:MF_01987, ECO:0000269|PubMed:11563694, ECO:0000269|PubMed:3011794} http://enzyme.expasy.org/EC/2.7.1.15 {ECO:0000255|HAMAP-Rule:MF_01987, ECO:0000269|PubMed:11563694, ECO:0000269|PubMed:3011794} EchoBASE EB0811 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0811 EcoGene EG10818 http://www.ecogene.org/geneInfo.php?eg_id=EG10818 EnsemblBacteria AAC76775 http://www.ensemblgenomes.org/id/AAC76775 EnsemblBacteria AAC76775 http://www.ensemblgenomes.org/id/AAC76775 EnsemblBacteria BAE77536 http://www.ensemblgenomes.org/id/BAE77536 EnsemblBacteria BAE77536 http://www.ensemblgenomes.org/id/BAE77536 EnsemblBacteria BAE77536 http://www.ensemblgenomes.org/id/BAE77536 EnsemblBacteria b3752 http://www.ensemblgenomes.org/id/b3752 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004747 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004747 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0019303 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019303 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.1190.20 http://www.cathdb.info/version/latest/superfamily/3.40.1190.20 GeneID 948260 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948260 HAMAP MF_01987 http://hamap.expasy.org/unirule/MF_01987 HOGENOM HOG000235950 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000235950&db=HOGENOM6 InParanoid P0A9J6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9J6 IntAct P0A9J6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9J6* IntEnz 2.7.1.15 {ECO:0000255|HAMAP-Rule:MF_01987, ECO:0000269|PubMed:11563694, ECO:0000269|PubMed:3011794} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.15 {ECO:0000255|HAMAP-Rule:MF_01987, ECO:0000269|PubMed:11563694, ECO:0000269|PubMed:3011794} InterPro IPR002139 http://www.ebi.ac.uk/interpro/entry/IPR002139 InterPro IPR002173 http://www.ebi.ac.uk/interpro/entry/IPR002173 InterPro IPR011611 http://www.ebi.ac.uk/interpro/entry/IPR011611 InterPro IPR011877 http://www.ebi.ac.uk/interpro/entry/IPR011877 InterPro IPR029056 http://www.ebi.ac.uk/interpro/entry/IPR029056 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3731 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3731 KEGG_Gene eco:b3752 http://www.genome.jp/dbget-bin/www_bget?eco:b3752 KEGG_Orthology KO:K00852 http://www.genome.jp/dbget-bin/www_bget?KO:K00852 KEGG_Pathway ko00030 http://www.genome.jp/kegg-bin/show_pathway?ko00030 KEGG_Reaction rn:R01051 http://www.genome.jp/dbget-bin/www_bget?rn:R01051 KEGG_Reaction rn:R02750 http://www.genome.jp/dbget-bin/www_bget?rn:R02750 MINT MINT-1321131 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1321131 OMA NADHVIS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NADHVIS PDB 1GQT http://www.ebi.ac.uk/pdbe-srv/view/entry/1GQT PDB 1RK2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1RK2 PDB 1RKA http://www.ebi.ac.uk/pdbe-srv/view/entry/1RKA PDB 1RKD http://www.ebi.ac.uk/pdbe-srv/view/entry/1RKD PDB 1RKS http://www.ebi.ac.uk/pdbe-srv/view/entry/1RKS PDBsum 1GQT http://www.ebi.ac.uk/pdbsum/1GQT PDBsum 1RK2 http://www.ebi.ac.uk/pdbsum/1RK2 PDBsum 1RKA http://www.ebi.ac.uk/pdbsum/1RKA PDBsum 1RKD http://www.ebi.ac.uk/pdbsum/1RKD PDBsum 1RKS http://www.ebi.ac.uk/pdbsum/1RKS PRINTS PR00990 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00990 PROSITE PS00584 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00584 PSORT swissprot:RBSK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RBSK_ECOLI PSORT-B swissprot:RBSK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RBSK_ECOLI PSORT2 swissprot:RBSK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RBSK_ECOLI Pfam PF00294 http://pfam.xfam.org/family/PF00294 Phobius swissprot:RBSK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RBSK_ECOLI PhylomeDB P0A9J6 http://phylomedb.org/?seqid=P0A9J6 ProteinModelPortal P0A9J6 http://www.proteinmodelportal.org/query/uniprot/P0A9J6 PubMed 10438599 http://www.ncbi.nlm.nih.gov/pubmed/10438599 PubMed 11563694 http://www.ncbi.nlm.nih.gov/pubmed/11563694 PubMed 11786021 http://www.ncbi.nlm.nih.gov/pubmed/11786021 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16784868 http://www.ncbi.nlm.nih.gov/pubmed/16784868 PubMed 3011794 http://www.ncbi.nlm.nih.gov/pubmed/3011794 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9385653 http://www.ncbi.nlm.nih.gov/pubmed/9385653 PubMed 9519409 http://www.ncbi.nlm.nih.gov/pubmed/9519409 RefSeq NP_418208 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418208 RefSeq WP_001300603 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300603 SMR P0A9J6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9J6 STRING 511145.b3752 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3752&targetmode=cogs STRING COG0524 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0524&targetmode=cogs SUPFAM SSF53613 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53613 TIGRFAMs TIGR02152 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02152 UniProtKB RBSK_ECOLI http://www.uniprot.org/uniprot/RBSK_ECOLI UniProtKB-AC P0A9J6 http://www.uniprot.org/uniprot/P0A9J6 charge swissprot:RBSK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RBSK_ECOLI eggNOG COG0524 http://eggnogapi.embl.de/nog_data/html/tree/COG0524 eggNOG ENOG4108RVA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108RVA epestfind swissprot:RBSK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RBSK_ECOLI garnier swissprot:RBSK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RBSK_ECOLI helixturnhelix swissprot:RBSK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RBSK_ECOLI hmoment swissprot:RBSK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RBSK_ECOLI iep swissprot:RBSK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RBSK_ECOLI inforesidue swissprot:RBSK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RBSK_ECOLI octanol swissprot:RBSK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RBSK_ECOLI pepcoil swissprot:RBSK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RBSK_ECOLI pepdigest swissprot:RBSK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RBSK_ECOLI pepinfo swissprot:RBSK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RBSK_ECOLI pepnet swissprot:RBSK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RBSK_ECOLI pepstats swissprot:RBSK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RBSK_ECOLI pepwheel swissprot:RBSK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RBSK_ECOLI pepwindow swissprot:RBSK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RBSK_ECOLI sigcleave swissprot:RBSK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RBSK_ECOLI ## Database ID URL or Descriptions # BioGrid 4261163 10 # EcoGene EG14064 yegU # GO_function GO:0016787 hydrolase activity; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # IntAct P76418 3 # InterPro IPR005502 Ribosyl_crysJ1 # KEGG_Brite ko01000 Enzymes # Organism YEGU_ECOLI Escherichia coli (strain K12) # PATRIC 32119531 VBIEscCol129921_2176 # PIR B64977 B64977 # Pfam PF03747 ADP_ribosyl_GH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEGU_ECOLI Uncharacterized protein YegU # RefSeq NP_416602 NC_000913.3 # RefSeq WP_000846217 NZ_LN832404.1 # SIMILARITY Belongs to the ADP-ribosylglycohydrolase family. {ECO 0000305}. # SUPFAM SSF101478 SSF101478 # eggNOG COG1397 LUCA # eggNOG ENOG4108KD5 Bacteria BLAST swissprot:YEGU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEGU_ECOLI BioCyc ECOL316407:JW2086-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2086-MONOMER BioCyc EcoCyc:G7131-MONOMER http://biocyc.org/getid?id=EcoCyc:G7131-MONOMER COG COG1397 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1397 DIP DIP-11891N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11891N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.2.2.- http://www.genome.jp/dbget-bin/www_bget?EC:3.2.2.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.2.2.- http://enzyme.expasy.org/EC/3.2.2.- EchoBASE EB3817 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3817 EcoGene EG14064 http://www.ecogene.org/geneInfo.php?eg_id=EG14064 EnsemblBacteria AAC75160 http://www.ensemblgenomes.org/id/AAC75160 EnsemblBacteria AAC75160 http://www.ensemblgenomes.org/id/AAC75160 EnsemblBacteria BAE76585 http://www.ensemblgenomes.org/id/BAE76585 EnsemblBacteria BAE76585 http://www.ensemblgenomes.org/id/BAE76585 EnsemblBacteria BAE76585 http://www.ensemblgenomes.org/id/BAE76585 EnsemblBacteria b2099 http://www.ensemblgenomes.org/id/b2099 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016787 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016787 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GeneID 946630 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946630 HOGENOM HOG000040232 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000040232&db=HOGENOM6 InParanoid P76418 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76418 IntAct P76418 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76418* IntEnz 3.2.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.2.2 InterPro IPR005502 http://www.ebi.ac.uk/interpro/entry/IPR005502 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2086 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2086 KEGG_Gene eco:b2099 http://www.genome.jp/dbget-bin/www_bget?eco:b2099 KEGG_Orthology KO:K05521 http://www.genome.jp/dbget-bin/www_bget?KO:K05521 OMA ETCRATH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ETCRATH PSORT swissprot:YEGU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEGU_ECOLI PSORT-B swissprot:YEGU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEGU_ECOLI PSORT2 swissprot:YEGU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEGU_ECOLI Pfam PF03747 http://pfam.xfam.org/family/PF03747 Phobius swissprot:YEGU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEGU_ECOLI PhylomeDB P76418 http://phylomedb.org/?seqid=P76418 ProteinModelPortal P76418 http://www.proteinmodelportal.org/query/uniprot/P76418 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416602 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416602 RefSeq WP_000846217 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000846217 STRING 511145.b2099 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2099&targetmode=cogs STRING COG1397 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1397&targetmode=cogs SUPFAM SSF101478 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF101478 UniProtKB YEGU_ECOLI http://www.uniprot.org/uniprot/YEGU_ECOLI UniProtKB-AC P76418 http://www.uniprot.org/uniprot/P76418 charge swissprot:YEGU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEGU_ECOLI eggNOG COG1397 http://eggnogapi.embl.de/nog_data/html/tree/COG1397 eggNOG ENOG4108KD5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108KD5 epestfind swissprot:YEGU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEGU_ECOLI garnier swissprot:YEGU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEGU_ECOLI helixturnhelix swissprot:YEGU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEGU_ECOLI hmoment swissprot:YEGU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEGU_ECOLI iep swissprot:YEGU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEGU_ECOLI inforesidue swissprot:YEGU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEGU_ECOLI octanol swissprot:YEGU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEGU_ECOLI pepcoil swissprot:YEGU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEGU_ECOLI pepdigest swissprot:YEGU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEGU_ECOLI pepinfo swissprot:YEGU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEGU_ECOLI pepnet swissprot:YEGU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEGU_ECOLI pepstats swissprot:YEGU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEGU_ECOLI pepwheel swissprot:YEGU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEGU_ECOLI pepwindow swissprot:YEGU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEGU_ECOLI sigcleave swissprot:YEGU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEGU_ECOLI ## Database ID URL or Descriptions # AltName NFSB_ECOLI Dihydropteridine reductase # AltName NFSB_ECOLI FMN-dependent nitroreductase # BIOPHYSICOCHEMICAL PROPERTIES NFSB_ECOLI Kinetic parameters KM=350 uM for NADH {ECO 0000269|PubMed 15684426}; KM=1850 uM for nitrofurazone {ECO 0000269|PubMed 15684426}; # BioGrid 4262913 3 # CATALYTIC ACTIVITY NFSB_ECOLI A 5,6,7,8-tetrahydropteridine + NAD(P)(+) = a 6,7-dihydropteridine + NAD(P)H. # CDD cd02149 NfsB_like_nitroreductase # COFACTOR Name=FMN; Xref=ChEBI:CHEBI 58210; # ENZYME REGULATION Subject to competitive inhibition by dicoumarol, nicotinic acid and acetate with respect to NADH. Subject to uncompetitive inhibition by dicoumarol, nicotinic acid and acetate with respect to nitrofurazone and nitrofurantoin. {ECO:0000269|PubMed 15684426}. # EcoGene EG20151 nfsB # FUNCTION NFSB_ECOLI Reduction of a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalents; two electrons are transferred. Capable of reducing nitrofurazone, quinones and the anti-tumor agent CB1954 (5- (aziridin-1-yl)-2,4-dinitrobenzamide). The reduction of CB1954 results in the generation of cytotoxic species. {ECO 0000269|PubMed 15684426}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0004155 6,7-dihydropteridine reductase activity; IDA:EcoCyc. # GO_function GO:0010181 FMN binding; IDA:EcoCyc. # GO_function GO:0018545 NAD(P)H nitroreductase activity; IDA:EcoCyc. # GO_process GO:0046256 2,4,6-trinitrotoluene catabolic process; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # Gene3D 3.40.109.10 -; 1. # INTERACTION NFSB_ECOLI Self; NbExp=2; IntAct=EBI-909296, EBI-909296; # IntAct P38489 12 # InterPro IPR000415 Nitroreductase-like # InterPro IPR029479 Nitroreductase # InterPro IPR033878 NfsB-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00633 Nitrotoluene degradation # Organism NFSB_ECOLI Escherichia coli (strain K12) # PATRIC 32116324 VBIEscCol129921_0602 # PDB 1DS7 X-ray; 2.06 A; A/B=1-217 # PDB 1ICR X-ray; 1.70 A; A/B=1-217 # PDB 1ICU X-ray; 1.80 A; A/B/C/D=1-217 # PDB 1ICV X-ray; 2.40 A; A/B/C/D=1-217 # PDB 1IDT X-ray; 2.00 A; A/B=1-217 # PDB 1OO5 X-ray; 2.50 A; A/B=1-217 # PDB 1OO6 X-ray; 2.00 A; A/B=1-217 # PDB 1OON X-ray; 2.49 A; A/B=1-217 # PDB 1OOQ X-ray; 2.00 A; A/B=1-217 # PDB 1YKI X-ray; 1.70 A; A/B/C/D=1-217 # PDB 1YLR X-ray; 1.70 A; A/B=1-217 # PDB 1YLU X-ray; 2.00 A; A/B=1-217 # PDB 3X21 X-ray; 3.00 A; A/B/C/D/E/F/G/H/I/J=1-217 # PDB 3X22 X-ray; 2.00 A; A/B=1-217 # PIR I67685 I67685 # PIR S01818 S01818 # Pfam PF00881 Nitroreductase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NFSB_ECOLI Oxygen-insensitive NAD(P)H nitroreductase # RefSeq NP_415110 NC_000913.3 # RefSeq WP_000351487 NZ_LN832404.1 # SIMILARITY Belongs to the nitroreductase family. {ECO 0000305}. # SUBUNIT NFSB_ECOLI Homodimer. {ECO 0000269|PubMed 11020276, ECO 0000269|PubMed 11491290, ECO 0000269|PubMed 12954054, ECO 0000269|PubMed 15684426}. # SUPFAM SSF55469 SSF55469 # eggNOG COG0778 LUCA # eggNOG ENOG4108RCM Bacteria BLAST swissprot:NFSB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NFSB_ECOLI BioCyc ECOL316407:JW0567-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0567-MONOMER BioCyc EcoCyc:DIHYDROPTERIREDUCT-MONOMER http://biocyc.org/getid?id=EcoCyc:DIHYDROPTERIREDUCT-MONOMER BioCyc MetaCyc:DIHYDROPTERIREDUCT-MONOMER http://biocyc.org/getid?id=MetaCyc:DIHYDROPTERIREDUCT-MONOMER COG COG0778 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0778 DIP DIP-10330N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10330N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.2001.4653 http://dx.doi.org/10.1006/jmbi.2001.4653 DOI 10.1016/0006-2952(92)90671-5 http://dx.doi.org/10.1016/0006-2952(92)90671-5 DOI 10.1021/jm000159m http://dx.doi.org/10.1021/jm000159m DOI 10.1021/jm030843b http://dx.doi.org/10.1021/jm030843b DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M409652200 http://dx.doi.org/10.1074/jbc.M409652200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/oxfordjournals.jbchem.a021473 http://dx.doi.org/10.1093/oxfordjournals.jbchem.a021473 DOI 10.1111/j.1574-6968.1994.tb07284.x http://dx.doi.org/10.1111/j.1574-6968.1994.tb07284.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EC_number EC:1.5.1.34 http://www.genome.jp/dbget-bin/www_bget?EC:1.5.1.34 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D25414 http://www.ebi.ac.uk/ena/data/view/D25414 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U07860 http://www.ebi.ac.uk/ena/data/view/U07860 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- ENZYME 1.5.1.34 http://enzyme.expasy.org/EC/1.5.1.34 EchoBASE EB4146 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4146 EcoGene EG20151 http://www.ecogene.org/geneInfo.php?eg_id=EG20151 EnsemblBacteria AAC73679 http://www.ensemblgenomes.org/id/AAC73679 EnsemblBacteria AAC73679 http://www.ensemblgenomes.org/id/AAC73679 EnsemblBacteria BAA35218 http://www.ensemblgenomes.org/id/BAA35218 EnsemblBacteria BAA35218 http://www.ensemblgenomes.org/id/BAA35218 EnsemblBacteria BAA35218 http://www.ensemblgenomes.org/id/BAA35218 EnsemblBacteria b0578 http://www.ensemblgenomes.org/id/b0578 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0004155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004155 GO_function GO:0010181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010181 GO_function GO:0018545 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018545 GO_process GO:0046256 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046256 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 3.40.109.10 http://www.cathdb.info/version/latest/superfamily/3.40.109.10 GeneID 945778 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945778 HOGENOM HOG000146740 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000146740&db=HOGENOM6 InParanoid P38489 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P38489 IntAct P38489 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P38489* IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 IntEnz 1.5.1.34 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.5.1.34 InterPro IPR000415 http://www.ebi.ac.uk/interpro/entry/IPR000415 InterPro IPR029479 http://www.ebi.ac.uk/interpro/entry/IPR029479 InterPro IPR033878 http://www.ebi.ac.uk/interpro/entry/IPR033878 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0567 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0567 KEGG_Gene eco:b0578 http://www.genome.jp/dbget-bin/www_bget?eco:b0578 KEGG_Orthology KO:K10679 http://www.genome.jp/dbget-bin/www_bget?KO:K10679 KEGG_Pathway ko00633 http://www.genome.jp/kegg-bin/show_pathway?ko00633 KEGG_Reaction rn:R08014 http://www.genome.jp/dbget-bin/www_bget?rn:R08014 KEGG_Reaction rn:R08017 http://www.genome.jp/dbget-bin/www_bget?rn:R08017 KEGG_Reaction rn:R08042 http://www.genome.jp/dbget-bin/www_bget?rn:R08042 OMA CLAEEGL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CLAEEGL PDB 1DS7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1DS7 PDB 1ICR http://www.ebi.ac.uk/pdbe-srv/view/entry/1ICR PDB 1ICU http://www.ebi.ac.uk/pdbe-srv/view/entry/1ICU PDB 1ICV http://www.ebi.ac.uk/pdbe-srv/view/entry/1ICV PDB 1IDT http://www.ebi.ac.uk/pdbe-srv/view/entry/1IDT PDB 1OO5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1OO5 PDB 1OO6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1OO6 PDB 1OON http://www.ebi.ac.uk/pdbe-srv/view/entry/1OON PDB 1OOQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1OOQ PDB 1YKI http://www.ebi.ac.uk/pdbe-srv/view/entry/1YKI PDB 1YLR http://www.ebi.ac.uk/pdbe-srv/view/entry/1YLR PDB 1YLU http://www.ebi.ac.uk/pdbe-srv/view/entry/1YLU PDB 3X21 http://www.ebi.ac.uk/pdbe-srv/view/entry/3X21 PDB 3X22 http://www.ebi.ac.uk/pdbe-srv/view/entry/3X22 PDBsum 1DS7 http://www.ebi.ac.uk/pdbsum/1DS7 PDBsum 1ICR http://www.ebi.ac.uk/pdbsum/1ICR PDBsum 1ICU http://www.ebi.ac.uk/pdbsum/1ICU PDBsum 1ICV http://www.ebi.ac.uk/pdbsum/1ICV PDBsum 1IDT http://www.ebi.ac.uk/pdbsum/1IDT PDBsum 1OO5 http://www.ebi.ac.uk/pdbsum/1OO5 PDBsum 1OO6 http://www.ebi.ac.uk/pdbsum/1OO6 PDBsum 1OON http://www.ebi.ac.uk/pdbsum/1OON PDBsum 1OOQ http://www.ebi.ac.uk/pdbsum/1OOQ PDBsum 1YKI http://www.ebi.ac.uk/pdbsum/1YKI PDBsum 1YLR http://www.ebi.ac.uk/pdbsum/1YLR PDBsum 1YLU http://www.ebi.ac.uk/pdbsum/1YLU PDBsum 3X21 http://www.ebi.ac.uk/pdbsum/3X21 PDBsum 3X22 http://www.ebi.ac.uk/pdbsum/3X22 PSORT swissprot:NFSB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NFSB_ECOLI PSORT-B swissprot:NFSB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NFSB_ECOLI PSORT2 swissprot:NFSB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NFSB_ECOLI Pfam PF00881 http://pfam.xfam.org/family/PF00881 Phobius swissprot:NFSB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NFSB_ECOLI PhylomeDB P38489 http://phylomedb.org/?seqid=P38489 ProteinModelPortal P38489 http://www.proteinmodelportal.org/query/uniprot/P38489 PubMed 11020276 http://www.ncbi.nlm.nih.gov/pubmed/11020276 PubMed 11491290 http://www.ncbi.nlm.nih.gov/pubmed/11491290 PubMed 12954054 http://www.ncbi.nlm.nih.gov/pubmed/12954054 PubMed 1472094 http://www.ncbi.nlm.nih.gov/pubmed/1472094 PubMed 15684426 http://www.ncbi.nlm.nih.gov/pubmed/15684426 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3060113 http://www.ncbi.nlm.nih.gov/pubmed/3060113 PubMed 7813889 http://www.ncbi.nlm.nih.gov/pubmed/7813889 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 8947835 http://www.ncbi.nlm.nih.gov/pubmed/8947835 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_415110 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415110 RefSeq WP_000351487 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000351487 SMR P38489 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P38489 STRING 511145.b0578 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0578&targetmode=cogs STRING COG0778 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0778&targetmode=cogs SUPFAM SSF55469 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55469 SWISS-2DPAGE P38489 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P38489 UniProtKB NFSB_ECOLI http://www.uniprot.org/uniprot/NFSB_ECOLI UniProtKB-AC P38489 http://www.uniprot.org/uniprot/P38489 charge swissprot:NFSB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NFSB_ECOLI eggNOG COG0778 http://eggnogapi.embl.de/nog_data/html/tree/COG0778 eggNOG ENOG4108RCM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108RCM epestfind swissprot:NFSB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NFSB_ECOLI garnier swissprot:NFSB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NFSB_ECOLI helixturnhelix swissprot:NFSB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NFSB_ECOLI hmoment swissprot:NFSB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NFSB_ECOLI iep swissprot:NFSB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NFSB_ECOLI inforesidue swissprot:NFSB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NFSB_ECOLI octanol swissprot:NFSB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NFSB_ECOLI pepcoil swissprot:NFSB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NFSB_ECOLI pepdigest swissprot:NFSB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NFSB_ECOLI pepinfo swissprot:NFSB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NFSB_ECOLI pepnet swissprot:NFSB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NFSB_ECOLI pepstats swissprot:NFSB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NFSB_ECOLI pepwheel swissprot:NFSB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NFSB_ECOLI pepwindow swissprot:NFSB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NFSB_ECOLI sigcleave swissprot:NFSB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NFSB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260282 42 # EcoGene EG13965 sufB # FUNCTION SUFB_ECOLI The SufBCD complex acts synergistically with SufE to stimulate the cysteine desulfurase activity of SufS. The SufBCD complex contributes to the assembly or repair of oxygen-labile iron-sulfur clusters under oxidative stress. May facilitate iron uptake from extracellular iron chelators under iron limitation. {ECO 0000269|PubMed 12941942}. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IDA:EcoCyc. # GO_process GO:0016226 iron-sulfur cluster assembly; IMP:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0051186 cofactor metabolic process # INTERACTION SUFB_ECOLI P77667 sufA; NbExp=5; IntAct=EBI-562758, EBI-1125011; P77499 sufC; NbExp=13; IntAct=EBI-562758, EBI-561601; P77689 sufD; NbExp=13; IntAct=EBI-562758, EBI-562751; # IntAct P77522 5 # InterPro IPR000825 SUF_FeS_clus_asmbl_SufBD # InterPro IPR010231 SUF_FeS_clus_asmbl_SufB # Organism SUFB_ECOLI Escherichia coli (strain K12) # PATRIC 32118672 VBIEscCol129921_1754 # PDB 5AWF X-ray; 2.96 A; A/E=1-495 # PDB 5AWG X-ray; 4.28 A; A/E=1-495 # PIR C64926 C64926 # Pfam PF01458 UPF0051 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SUFB_ECOLI FeS cluster assembly protein SufB # RefSeq NP_416198 NC_000913.3 # RefSeq WP_000089364 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0051 (ycf24) family. {ECO 0000305}. # SUBUNIT Part of the SufBCD complex that contains SufB, SufC and SufD. {ECO:0000269|PubMed 12941942}. # TIGRFAMs TIGR01980 sufB # eggNOG COG0719 LUCA # eggNOG ENOG4105DIW Bacteria BLAST swissprot:SUFB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SUFB_ECOLI BioCyc ECOL316407:JW5273-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5273-MONOMER BioCyc EcoCyc:G6909-MONOMER http://biocyc.org/getid?id=EcoCyc:G6909-MONOMER COG COG0719 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0719 DIP DIP-10938N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10938N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M308004200 http://dx.doi.org/10.1074/jbc.M308004200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3723 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3723 EcoGene EG13965 http://www.ecogene.org/geneInfo.php?eg_id=EG13965 EnsemblBacteria AAC74753 http://www.ensemblgenomes.org/id/AAC74753 EnsemblBacteria AAC74753 http://www.ensemblgenomes.org/id/AAC74753 EnsemblBacteria BAA15454 http://www.ensemblgenomes.org/id/BAA15454 EnsemblBacteria BAA15454 http://www.ensemblgenomes.org/id/BAA15454 EnsemblBacteria BAA15454 http://www.ensemblgenomes.org/id/BAA15454 EnsemblBacteria b1683 http://www.ensemblgenomes.org/id/b1683 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0016226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016226 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GeneID 945753 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945753 HOGENOM HOG000069112 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000069112&db=HOGENOM6 InParanoid P77522 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77522 IntAct P77522 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77522* InterPro IPR000825 http://www.ebi.ac.uk/interpro/entry/IPR000825 InterPro IPR010231 http://www.ebi.ac.uk/interpro/entry/IPR010231 KEGG_Gene ecj:JW5273 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5273 KEGG_Gene eco:b1683 http://www.genome.jp/dbget-bin/www_bget?eco:b1683 KEGG_Orthology KO:K09014 http://www.genome.jp/dbget-bin/www_bget?KO:K09014 OMA YPYVDVR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YPYVDVR PDB 5AWF http://www.ebi.ac.uk/pdbe-srv/view/entry/5AWF PDB 5AWG http://www.ebi.ac.uk/pdbe-srv/view/entry/5AWG PDBsum 5AWF http://www.ebi.ac.uk/pdbsum/5AWF PDBsum 5AWG http://www.ebi.ac.uk/pdbsum/5AWG PSORT swissprot:SUFB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SUFB_ECOLI PSORT-B swissprot:SUFB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SUFB_ECOLI PSORT2 swissprot:SUFB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SUFB_ECOLI Pfam PF01458 http://pfam.xfam.org/family/PF01458 Phobius swissprot:SUFB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SUFB_ECOLI PhylomeDB P77522 http://phylomedb.org/?seqid=P77522 ProteinModelPortal P77522 http://www.proteinmodelportal.org/query/uniprot/P77522 PubMed 10322040 http://www.ncbi.nlm.nih.gov/pubmed/10322040 PubMed 12941942 http://www.ncbi.nlm.nih.gov/pubmed/12941942 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416198 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416198 RefSeq WP_000089364 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000089364 SMR P77522 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77522 STRING 511145.b1683 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1683&targetmode=cogs STRING COG0719 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0719&targetmode=cogs TIGRFAMs TIGR01980 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01980 UniProtKB SUFB_ECOLI http://www.uniprot.org/uniprot/SUFB_ECOLI UniProtKB-AC P77522 http://www.uniprot.org/uniprot/P77522 charge swissprot:SUFB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SUFB_ECOLI eggNOG COG0719 http://eggnogapi.embl.de/nog_data/html/tree/COG0719 eggNOG ENOG4105DIW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DIW epestfind swissprot:SUFB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SUFB_ECOLI garnier swissprot:SUFB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SUFB_ECOLI helixturnhelix swissprot:SUFB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SUFB_ECOLI hmoment swissprot:SUFB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SUFB_ECOLI iep swissprot:SUFB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SUFB_ECOLI inforesidue swissprot:SUFB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SUFB_ECOLI octanol swissprot:SUFB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SUFB_ECOLI pepcoil swissprot:SUFB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SUFB_ECOLI pepdigest swissprot:SUFB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SUFB_ECOLI pepinfo swissprot:SUFB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SUFB_ECOLI pepnet swissprot:SUFB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SUFB_ECOLI pepstats swissprot:SUFB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SUFB_ECOLI pepwheel swissprot:SUFB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SUFB_ECOLI pepwindow swissprot:SUFB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SUFB_ECOLI sigcleave swissprot:SUFB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SUFB_ECOLI ## Database ID URL or Descriptions # AltName ABRB_ECOLI AidB regulator # EcoGene EG13310 abrB # FUNCTION ABRB_ECOLI Seems to be involved in the regulation of AidB. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0010628 positive regulation of gene expression; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0008150 biological_process # InterPro IPR007820 AbrB_fam # InterPro IPR017516 AbrB_dup # Organism ABRB_ECOLI Escherichia coli (strain K12) # PATRIC 32116625 VBIEscCol129921_0745 # PIR B64807 B64807 # PIRSF PIRSF038991 Protein_AbrB # Pfam PF05145 AmoA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ABRB_ECOLI Protein AbrB # RefSeq NP_415243 NC_000913.3 # RefSeq WP_001336221 NZ_LN832404.1 # SIMILARITY Belongs to the AbrB family. {ECO 0000305}. # SUBCELLULAR LOCATION ABRB_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # TIGRFAMs TIGR03082 Gneg_AbrB_dup; 2 # eggNOG COG3180 LUCA # eggNOG ENOG4108KK1 Bacteria BLAST swissprot:ABRB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ABRB_ECOLI BioCyc ECOL316407:JW5097-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5097-MONOMER BioCyc EcoCyc:G6384-MONOMER http://biocyc.org/getid?id=EcoCyc:G6384-MONOMER COG COG3180 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3180 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3094 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3094 EcoGene EG13310 http://www.ecogene.org/geneInfo.php?eg_id=EG13310 EnsemblBacteria AAC73809 http://www.ensemblgenomes.org/id/AAC73809 EnsemblBacteria AAC73809 http://www.ensemblgenomes.org/id/AAC73809 EnsemblBacteria BAA35379 http://www.ensemblgenomes.org/id/BAA35379 EnsemblBacteria BAA35379 http://www.ensemblgenomes.org/id/BAA35379 EnsemblBacteria BAA35379 http://www.ensemblgenomes.org/id/BAA35379 EnsemblBacteria b0715 http://www.ensemblgenomes.org/id/b0715 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0010628 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010628 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 945321 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945321 HOGENOM HOG000076013 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000076013&db=HOGENOM6 InParanoid P75747 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75747 InterPro IPR007820 http://www.ebi.ac.uk/interpro/entry/IPR007820 InterPro IPR017516 http://www.ebi.ac.uk/interpro/entry/IPR017516 KEGG_Gene ecj:JW5097 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5097 KEGG_Gene eco:b0715 http://www.genome.jp/dbget-bin/www_bget?eco:b0715 KEGG_Orthology KO:K07120 http://www.genome.jp/dbget-bin/www_bget?KO:K07120 OMA LLGPMIV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LLGPMIV PSORT swissprot:ABRB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ABRB_ECOLI PSORT-B swissprot:ABRB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ABRB_ECOLI PSORT2 swissprot:ABRB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ABRB_ECOLI Pfam PF05145 http://pfam.xfam.org/family/PF05145 Phobius swissprot:ABRB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ABRB_ECOLI PhylomeDB P75747 http://phylomedb.org/?seqid=P75747 ProteinModelPortal P75747 http://www.proteinmodelportal.org/query/uniprot/P75747 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8002588 http://www.ncbi.nlm.nih.gov/pubmed/8002588 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415243 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415243 RefSeq WP_001336221 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001336221 STRING 511145.b0715 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0715&targetmode=cogs STRING COG3180 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3180&targetmode=cogs TIGRFAMs TIGR03082 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03082 UniProtKB ABRB_ECOLI http://www.uniprot.org/uniprot/ABRB_ECOLI UniProtKB-AC P75747 http://www.uniprot.org/uniprot/P75747 charge swissprot:ABRB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ABRB_ECOLI eggNOG COG3180 http://eggnogapi.embl.de/nog_data/html/tree/COG3180 eggNOG ENOG4108KK1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108KK1 epestfind swissprot:ABRB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ABRB_ECOLI garnier swissprot:ABRB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ABRB_ECOLI helixturnhelix swissprot:ABRB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ABRB_ECOLI hmoment swissprot:ABRB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ABRB_ECOLI iep swissprot:ABRB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ABRB_ECOLI inforesidue swissprot:ABRB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ABRB_ECOLI octanol swissprot:ABRB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ABRB_ECOLI pepcoil swissprot:ABRB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ABRB_ECOLI pepdigest swissprot:ABRB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ABRB_ECOLI pepinfo swissprot:ABRB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ABRB_ECOLI pepnet swissprot:ABRB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ABRB_ECOLI pepstats swissprot:ABRB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ABRB_ECOLI pepwheel swissprot:ABRB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ABRB_ECOLI pepwindow swissprot:ABRB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ABRB_ECOLI sigcleave swissprot:ABRB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ABRB_ECOLI ## Database ID URL or Descriptions # AltName END4_ECOLI Endodeoxyribonuclease IV # AltName END4_ECOLI Endonuclease IV # BRENDA 3.1.21 2026 # BioGrid 4261799 22 # CATALYTIC ACTIVITY END4_ECOLI Endonucleolytic cleavage to 5'- phosphooligonucleotide end-products. # COFACTOR END4_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Note=Binds 3 Zn(2+) ions. Can also bind Mn(2+) ions.; # EcoGene EG10651 nfo # FUNCTION END4_ECOLI Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_function GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity; IBA:GO_Central. # GO_function GO:0004519 endonuclease activity; IDA:EcoCyc. # GO_function GO:0008081 phosphoric diester hydrolase activity; IBA:GO_Central. # GO_function GO:0008270 zinc ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008833 deoxyribonuclease IV (phage-T4-induced) activity; IEA:UniProtKB-HAMAP. # GO_process GO:0000726 non-recombinational repair; IDA:EcoCyc. # GO_process GO:0006284 base-excision repair; IBA:GO_Central. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004518 nuclease activity # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # Gene3D 3.20.20.150 -; 1. # HAMAP MF_00152 Nfo # INDUCTION END4_ECOLI Endonuclease IV is induced by agents which generate superoxide radical anions. # IntAct P0A6C1 10 # InterPro IPR001719 AP_endonuc_2 # InterPro IPR013022 Xyl_isomerase-like_TIM-brl # InterPro IPR018246 AP_endonuc_F2_Zn_BS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko03410 Base excision repair # Organism END4_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21445 PTHR21445 # PATRIC 32119667 VBIEscCol129921_2244 # PDB 1QTW X-ray; 1.02 A; A=1-285 # PDB 1QUM X-ray; 1.55 A; A=1-285 # PDB 2NQ9 X-ray; 1.45 A; A=1-285 # PDB 2NQH X-ray; 1.10 A; A=1-285 # PDB 2NQJ X-ray; 2.45 A; A/B=1-285 # PDB 4K1G X-ray; 1.90 A; A/B=1-285 # PIR F64984 NDEC4 # PROSITE PS00729 AP_NUCLEASE_F2_1 # PROSITE PS00730 AP_NUCLEASE_F2_2 # PROSITE PS00731 AP_NUCLEASE_F2_3 # PROSITE PS51432 AP_NUCLEASE_F2_4 # Pfam PF01261 AP_endonuc_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName END4_ECOLI Endonuclease 4 # RefSeq NP_416664 NC_000913.3 # RefSeq WP_000873894 NZ_LN832404.1 # SIMILARITY Belongs to the AP endonuclease 2 family. {ECO 0000305}. # SMART SM00518 AP2Ec # SUBUNIT END4_ECOLI Monomer. # SUPFAM SSF51658 SSF51658 # TIGRFAMs TIGR00587 nfo # eggNOG COG0648 LUCA # eggNOG ENOG4105EFU Bacteria BLAST swissprot:END4_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:END4_ECOLI BioCyc ECOL316407:JW2146-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2146-MONOMER BioCyc EcoCyc:EG10651-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10651-MONOMER BioCyc MetaCyc:EG10651-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10651-MONOMER COG COG0648 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0648 DIP DIP-47966N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47966N DOI 10.1016/S0092-8674(00)81968-6 http://dx.doi.org/10.1016/S0092-8674(00)81968-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.21.2 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.21.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M22591 http://www.ebi.ac.uk/ena/data/view/M22591 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.21.2 http://enzyme.expasy.org/EC/3.1.21.2 EchoBASE EB0645 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0645 EcoGene EG10651 http://www.ecogene.org/geneInfo.php?eg_id=EG10651 EnsemblBacteria AAC75220 http://www.ensemblgenomes.org/id/AAC75220 EnsemblBacteria AAC75220 http://www.ensemblgenomes.org/id/AAC75220 EnsemblBacteria BAE76636 http://www.ensemblgenomes.org/id/BAE76636 EnsemblBacteria BAE76636 http://www.ensemblgenomes.org/id/BAE76636 EnsemblBacteria BAE76636 http://www.ensemblgenomes.org/id/BAE76636 EnsemblBacteria b2159 http://www.ensemblgenomes.org/id/b2159 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003906 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003906 GO_function GO:0004519 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004519 GO_function GO:0008081 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008081 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0008833 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008833 GO_process GO:0000726 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000726 GO_process GO:0006284 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006284 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.20.20.150 http://www.cathdb.info/version/latest/superfamily/3.20.20.150 GeneID 946669 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946669 HAMAP MF_00152 http://hamap.expasy.org/unirule/MF_00152 HOGENOM HOG000224893 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000224893&db=HOGENOM6 InParanoid P0A6C1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6C1 IntAct P0A6C1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6C1* IntEnz 3.1.21.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.21.2 InterPro IPR001719 http://www.ebi.ac.uk/interpro/entry/IPR001719 InterPro IPR013022 http://www.ebi.ac.uk/interpro/entry/IPR013022 InterPro IPR018246 http://www.ebi.ac.uk/interpro/entry/IPR018246 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW2146 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2146 KEGG_Gene eco:b2159 http://www.genome.jp/dbget-bin/www_bget?eco:b2159 KEGG_Orthology KO:K01151 http://www.genome.jp/dbget-bin/www_bget?KO:K01151 KEGG_Pathway ko03410 http://www.genome.jp/kegg-bin/show_pathway?ko03410 MINT MINT-1242700 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1242700 OMA MKYVGAH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MKYVGAH PANTHER PTHR21445 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21445 PDB 1QTW http://www.ebi.ac.uk/pdbe-srv/view/entry/1QTW PDB 1QUM http://www.ebi.ac.uk/pdbe-srv/view/entry/1QUM PDB 2NQ9 http://www.ebi.ac.uk/pdbe-srv/view/entry/2NQ9 PDB 2NQH http://www.ebi.ac.uk/pdbe-srv/view/entry/2NQH PDB 2NQJ http://www.ebi.ac.uk/pdbe-srv/view/entry/2NQJ PDB 4K1G http://www.ebi.ac.uk/pdbe-srv/view/entry/4K1G PDBsum 1QTW http://www.ebi.ac.uk/pdbsum/1QTW PDBsum 1QUM http://www.ebi.ac.uk/pdbsum/1QUM PDBsum 2NQ9 http://www.ebi.ac.uk/pdbsum/2NQ9 PDBsum 2NQH http://www.ebi.ac.uk/pdbsum/2NQH PDBsum 2NQJ http://www.ebi.ac.uk/pdbsum/2NQJ PDBsum 4K1G http://www.ebi.ac.uk/pdbsum/4K1G PROSITE PS00729 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00729 PROSITE PS00730 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00730 PROSITE PS00731 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00731 PROSITE PS51432 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51432 PSORT swissprot:END4_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:END4_ECOLI PSORT-B swissprot:END4_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:END4_ECOLI PSORT2 swissprot:END4_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:END4_ECOLI Pfam PF01261 http://pfam.xfam.org/family/PF01261 Phobius swissprot:END4_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:END4_ECOLI PhylomeDB P0A6C1 http://phylomedb.org/?seqid=P0A6C1 ProteinModelPortal P0A6C1 http://www.proteinmodelportal.org/query/uniprot/P0A6C1 PubMed 10458614 http://www.ncbi.nlm.nih.gov/pubmed/10458614 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1720775 http://www.ncbi.nlm.nih.gov/pubmed/1720775 PubMed 2460435 http://www.ncbi.nlm.nih.gov/pubmed/2460435 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416664 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416664 RefSeq WP_000873894 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000873894 SMART SM00518 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00518 SMR P0A6C1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6C1 STRING 511145.b2159 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2159&targetmode=cogs STRING COG0648 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0648&targetmode=cogs SUPFAM SSF51658 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51658 TIGRFAMs TIGR00587 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00587 UniProtKB END4_ECOLI http://www.uniprot.org/uniprot/END4_ECOLI UniProtKB-AC P0A6C1 http://www.uniprot.org/uniprot/P0A6C1 charge swissprot:END4_ECOLI http://rest.g-language.org/emboss/charge/swissprot:END4_ECOLI eggNOG COG0648 http://eggnogapi.embl.de/nog_data/html/tree/COG0648 eggNOG ENOG4105EFU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EFU epestfind swissprot:END4_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:END4_ECOLI garnier swissprot:END4_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:END4_ECOLI helixturnhelix swissprot:END4_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:END4_ECOLI hmoment swissprot:END4_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:END4_ECOLI iep swissprot:END4_ECOLI http://rest.g-language.org/emboss/iep/swissprot:END4_ECOLI inforesidue swissprot:END4_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:END4_ECOLI octanol swissprot:END4_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:END4_ECOLI pepcoil swissprot:END4_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:END4_ECOLI pepdigest swissprot:END4_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:END4_ECOLI pepinfo swissprot:END4_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:END4_ECOLI pepnet swissprot:END4_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:END4_ECOLI pepstats swissprot:END4_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:END4_ECOLI pepwheel swissprot:END4_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:END4_ECOLI pepwindow swissprot:END4_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:END4_ECOLI sigcleave swissprot:END4_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:END4_ECOLI ## Database ID URL or Descriptions # AltName Heat shock protein HslV {ECO:0000255|HAMAP-Rule MF_00248} # BIOPHYSICOCHEMICAL PROPERTIES HSLV_ECOLI Kinetic parameters KM=5.2 uM for Arc-MYL-st11 (at 37 degrees Celsius) {ECO 0000269|PubMed 15696175}; Note=Arc is a repressor protein, Arc-MYL-st11 is a hyperstable variant of Arc.; Temperature dependence Optimum temperature is 55 degrees Celsius. {ECO 0000269|PubMed 15696175}; # BRENDA 3.4.25 2026 # BioGrid 4261781 262 # CATALYTIC ACTIVITY HSLV_ECOLI ATP-dependent cleavage of peptide bonds with broad specificity. {ECO 0000255|HAMAP-Rule MF_00248, ECO 0000269|PubMed 10419524, ECO 0000269|PubMed 10452560, ECO 0000269|PubMed 8650174, ECO 0000269|PubMed 9288941, ECO 0000269|PubMed 9393683}. # CAUTION PubMed:9013898 sequence is supposed to originate from rat but, based on sequence similarity, it seems that this is a case of bacterial contamination from E.coli. {ECO 0000305}. # CDD cd01913 protease_HslV # ENZYME REGULATION Allosterically activated by HslU binding. {ECO 0000305}. # EcoGene EG11676 hslV # FUNCTION HSLV_ECOLI Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. The complex has been shown to be involved in the specific degradation of heat shock induced transcription factors such as RpoH and SulA. In addition, small hydrophobic peptides are also hydrolyzed by HslV. HslV has weak protease activity even in the absence of HslU, but this activity is induced more than 100-fold in the presence of HslU. HslU recognizes protein substrates and unfolds these before guiding them to HslV for hydrolysis. HslV is not believed to degrade folded proteins. {ECO 0000255|HAMAP-Rule MF_00248, ECO 0000269|PubMed 10419524, ECO 0000269|PubMed 10452560, ECO 0000269|PubMed 15696175, ECO 0000269|PubMed 8650174, ECO 0000269|PubMed 8662828, ECO 0000269|PubMed 9288941, ECO 0000269|PubMed 9393683}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0005839 proteasome core complex; IEA:InterPro. # GO_component GO:0009376 HslUV protease complex; IEA:UniProtKB-HAMAP. # GO_function GO:0004298 threonine-type endopeptidase activity; IMP:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0009408 response to heat; IEP:EcoliWiki. # GO_process GO:0051603 proteolysis involved in cellular protein catabolic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_component GO:0043234 protein complex # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # Gene3D 3.60.20.10 -; 1. # HAMAP MF_00248 HslV # INDUCTION HSLV_ECOLI By heat shock. {ECO 0000255|HAMAP-Rule MF_00248, ECO 0000269|PubMed 8244018}. # INTERACTION HSLV_ECOLI Self; NbExp=4; IntAct=EBI-552265, EBI-552265; P0A6H5 hslU; NbExp=6; IntAct=EBI-552265, EBI-369317; # IntAct P0A7B8 32 # InterPro IPR001353 Proteasome_sua/b # InterPro IPR022281 ATP-dep_Prtase_HsIV_su # InterPro IPR023333 Proteasome_suB-type # InterPro IPR029055 Ntn_hydrolases_N # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # Organism HSLV_ECOLI Escherichia coli (strain K12) # PATRIC 32123379 VBIEscCol129921_4050 # PDB 1E94 X-ray; 2.80 A; A/B/C/D=2-176 # PDB 1G4A X-ray; 3.00 A; A/B/C/D=2-176 # PDB 1G4B X-ray; 7.00 A; M/N/O/P=2-176 # PDB 1HQY X-ray; 2.80 A; A/B/C/D=2-176 # PDB 1HT1 X-ray; 2.80 A; A/B/C/D/V/X/Y/Z=2-176 # PDB 1HT2 X-ray; 2.80 A; A/B/C/D/I/J/K/L=2-176 # PDB 1NED X-ray; 3.80 A; A/B/C=2-176 # PDB 4G4E X-ray; 2.89 A; A/B/C/D/E/F/G/H/I/J/K/L=2-175 # PIR JT0760 JT0760 # PIRSF PIRSF039093 HslV # PROSITE PS51476 PROTEASOME_BETA_2 # Pfam PF00227 Proteasome # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ATP-dependent protease subunit HslV {ECO:0000255|HAMAP-Rule MF_00248} # RefSeq NP_418367 NC_000913.3 # RefSeq WP_000208242 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase T1B family. HslV subfamily. {ECO:0000255|HAMAP-Rule MF_00248}. # SUBCELLULAR LOCATION HSLV_ECOLI Cytoplasm. # SUBUNIT HSLV_ECOLI A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP. {ECO 0000255|HAMAP-Rule MF_00248, ECO 0000269|PubMed 9177170}. # SUPFAM SSF56235 SSF56235 # TIGRFAMs TIGR03692 ATP_dep_HslV # eggNOG COG5405 LUCA # eggNOG ENOG4108R5P Bacteria BLAST swissprot:HSLV_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HSLV_ECOLI BioCyc ECOL316407:JW3903-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3903-MONOMER BioCyc EcoCyc:EG11676-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11676-MONOMER BioCyc MetaCyc:EG11676-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11676-MONOMER COG COG0638 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0638 DIP DIP-35866N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35866N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/bbrc.1997.7341 http://dx.doi.org/10.1006/bbrc.1997.7341 DOI 10.1016/0378-1119(93)90167-2 http://dx.doi.org/10.1016/0378-1119(93)90167-2 DOI 10.1016/S0014-5793(96)01485-8 http://dx.doi.org/10.1016/S0014-5793(96)01485-8 DOI 10.1016/S0014-5793(97)00742-4 http://dx.doi.org/10.1016/S0014-5793(97)00742-4 DOI 10.1016/S0014-5793(99)00935-7 http://dx.doi.org/10.1016/S0014-5793(99)00935-7 DOI 10.1016/S0969-2126(01)00570-6 http://dx.doi.org/10.1016/S0969-2126(01)00570-6 DOI 10.1016/S0969-2126(01)00670-0 http://dx.doi.org/10.1016/S0969-2126(01)00670-0 DOI 10.1038/35001629 http://dx.doi.org/10.1038/35001629 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsmb898 http://dx.doi.org/10.1038/nsmb898 DOI 10.1073/pnas.250491797 http://dx.doi.org/10.1073/pnas.250491797 DOI 10.1073/pnas.93.12.5808 http://dx.doi.org/10.1073/pnas.93.12.5808 DOI 10.1073/pnas.94.12.6070 http://dx.doi.org/10.1073/pnas.94.12.6070 DOI 10.1074/jbc.271.24.14035 http://dx.doi.org/10.1074/jbc.271.24.14035 DOI 10.1074/jbc.273.36.22929 http://dx.doi.org/10.1074/jbc.273.36.22929 DOI 10.1074/jbc.274.31.22002 http://dx.doi.org/10.1074/jbc.274.31.22002 DOI 10.1074/jbc.M109.045807 http://dx.doi.org/10.1074/jbc.M109.045807 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1111/j.1432-1033.1997.01143.x http://dx.doi.org/10.1111/j.1432-1033.1997.01143.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.25.2 {ECO:0000255|HAMAP-Rule:MF_00248} http://www.genome.jp/dbget-bin/www_bget?EC:3.4.25.2 {ECO:0000255|HAMAP-Rule:MF_00248} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D89965 http://www.ebi.ac.uk/ena/data/view/D89965 EMBL L14281 http://www.ebi.ac.uk/ena/data/view/L14281 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.4.25.2 {ECO:0000255|HAMAP-Rule:MF_00248} http://enzyme.expasy.org/EC/3.4.25.2 {ECO:0000255|HAMAP-Rule:MF_00248} EchoBASE EB1627 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1627 EcoGene EG11676 http://www.ecogene.org/geneInfo.php?eg_id=EG11676 EnsemblBacteria AAC76914 http://www.ensemblgenomes.org/id/AAC76914 EnsemblBacteria AAC76914 http://www.ensemblgenomes.org/id/AAC76914 EnsemblBacteria BAE77378 http://www.ensemblgenomes.org/id/BAE77378 EnsemblBacteria BAE77378 http://www.ensemblgenomes.org/id/BAE77378 EnsemblBacteria BAE77378 http://www.ensemblgenomes.org/id/BAE77378 EnsemblBacteria b3932 http://www.ensemblgenomes.org/id/b3932 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005839 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005839 GO_component GO:0009376 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009376 GO_function GO:0004298 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004298 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GO_process GO:0051603 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051603 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.60.20.10 http://www.cathdb.info/version/latest/superfamily/3.60.20.10 GeneID 948429 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948429 HAMAP MF_00248 http://hamap.expasy.org/unirule/MF_00248 HOGENOM HOG000064533 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000064533&db=HOGENOM6 InParanoid P0A7B8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7B8 IntAct P0A7B8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7B8* IntEnz 3.4.25.2 {ECO:0000255|HAMAP-Rule:MF_00248} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.25.2 {ECO:0000255|HAMAP-Rule:MF_00248} InterPro IPR001353 http://www.ebi.ac.uk/interpro/entry/IPR001353 InterPro IPR022281 http://www.ebi.ac.uk/interpro/entry/IPR022281 InterPro IPR023333 http://www.ebi.ac.uk/interpro/entry/IPR023333 InterPro IPR029055 http://www.ebi.ac.uk/interpro/entry/IPR029055 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW3903 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3903 KEGG_Gene eco:b3932 http://www.genome.jp/dbget-bin/www_bget?eco:b3932 KEGG_Orthology KO:K01419 http://www.genome.jp/dbget-bin/www_bget?KO:K01419 MINT MINT-1218940 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1218940 OMA IMKGNAR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IMKGNAR PDB 1E94 http://www.ebi.ac.uk/pdbe-srv/view/entry/1E94 PDB 1G4A http://www.ebi.ac.uk/pdbe-srv/view/entry/1G4A PDB 1G4B http://www.ebi.ac.uk/pdbe-srv/view/entry/1G4B PDB 1HQY http://www.ebi.ac.uk/pdbe-srv/view/entry/1HQY PDB 1HT1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1HT1 PDB 1HT2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1HT2 PDB 1NED http://www.ebi.ac.uk/pdbe-srv/view/entry/1NED PDB 4G4E http://www.ebi.ac.uk/pdbe-srv/view/entry/4G4E PDBsum 1E94 http://www.ebi.ac.uk/pdbsum/1E94 PDBsum 1G4A http://www.ebi.ac.uk/pdbsum/1G4A PDBsum 1G4B http://www.ebi.ac.uk/pdbsum/1G4B PDBsum 1HQY http://www.ebi.ac.uk/pdbsum/1HQY PDBsum 1HT1 http://www.ebi.ac.uk/pdbsum/1HT1 PDBsum 1HT2 http://www.ebi.ac.uk/pdbsum/1HT2 PDBsum 1NED http://www.ebi.ac.uk/pdbsum/1NED PDBsum 4G4E http://www.ebi.ac.uk/pdbsum/4G4E PROSITE PS51476 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51476 PSORT swissprot:HSLV_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HSLV_ECOLI PSORT-B swissprot:HSLV_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HSLV_ECOLI PSORT2 swissprot:HSLV_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HSLV_ECOLI Pfam PF00227 http://pfam.xfam.org/family/PF00227 Phobius swissprot:HSLV_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HSLV_ECOLI PhylomeDB P0A7B8 http://phylomedb.org/?seqid=P0A7B8 ProteinModelPortal P0A7B8 http://www.proteinmodelportal.org/query/uniprot/P0A7B8 PubMed 10419524 http://www.ncbi.nlm.nih.gov/pubmed/10419524 PubMed 10452560 http://www.ncbi.nlm.nih.gov/pubmed/10452560 PubMed 10693812 http://www.ncbi.nlm.nih.gov/pubmed/10693812 PubMed 11114186 http://www.ncbi.nlm.nih.gov/pubmed/11114186 PubMed 11250202 http://www.ncbi.nlm.nih.gov/pubmed/11250202 PubMed 11709174 http://www.ncbi.nlm.nih.gov/pubmed/11709174 PubMed 15696175 http://www.ncbi.nlm.nih.gov/pubmed/15696175 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19801685 http://www.ncbi.nlm.nih.gov/pubmed/19801685 PubMed 8244018 http://www.ncbi.nlm.nih.gov/pubmed/8244018 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 8650174 http://www.ncbi.nlm.nih.gov/pubmed/8650174 PubMed 8662828 http://www.ncbi.nlm.nih.gov/pubmed/8662828 PubMed 9013898 http://www.ncbi.nlm.nih.gov/pubmed/9013898 PubMed 9177170 http://www.ncbi.nlm.nih.gov/pubmed/9177170 PubMed 9257689 http://www.ncbi.nlm.nih.gov/pubmed/9257689 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9288941 http://www.ncbi.nlm.nih.gov/pubmed/9288941 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9299555 http://www.ncbi.nlm.nih.gov/pubmed/9299555 PubMed 9393683 http://www.ncbi.nlm.nih.gov/pubmed/9393683 PubMed 9722513 http://www.ncbi.nlm.nih.gov/pubmed/9722513 RefSeq NP_418367 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418367 RefSeq WP_000208242 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000208242 SMR P0A7B8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7B8 STRING 511145.b3932 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3932&targetmode=cogs STRING COG0638 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0638&targetmode=cogs SUPFAM SSF56235 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56235 SWISS-2DPAGE P0A7B8 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A7B8 TIGRFAMs TIGR03692 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03692 UniProtKB HSLV_ECOLI http://www.uniprot.org/uniprot/HSLV_ECOLI UniProtKB-AC P0A7B8 http://www.uniprot.org/uniprot/P0A7B8 charge swissprot:HSLV_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HSLV_ECOLI eggNOG COG5405 http://eggnogapi.embl.de/nog_data/html/tree/COG5405 eggNOG ENOG4108R5P http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108R5P epestfind swissprot:HSLV_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HSLV_ECOLI garnier swissprot:HSLV_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HSLV_ECOLI helixturnhelix swissprot:HSLV_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HSLV_ECOLI hmoment swissprot:HSLV_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HSLV_ECOLI iep swissprot:HSLV_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HSLV_ECOLI inforesidue swissprot:HSLV_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HSLV_ECOLI octanol swissprot:HSLV_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HSLV_ECOLI pepcoil swissprot:HSLV_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HSLV_ECOLI pepdigest swissprot:HSLV_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HSLV_ECOLI pepinfo swissprot:HSLV_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HSLV_ECOLI pepnet swissprot:HSLV_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HSLV_ECOLI pepstats swissprot:HSLV_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HSLV_ECOLI pepwheel swissprot:HSLV_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HSLV_ECOLI pepwindow swissprot:HSLV_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HSLV_ECOLI sigcleave swissprot:HSLV_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HSLV_ECOLI ## Database ID URL or Descriptions # BioGrid 4262938 20 # EcoGene EG10481 hycH # FUNCTION HYCH_ECOLI Seems to be required for the conversion of a precursor form of the large subunit of hydrogenlyase (HycE) into a mature form. {ECO 0000269|PubMed 1625581}. # GO_process GO:0051604 protein maturation; IMP:EcoCyc. # GOslim_process GO:0051604 protein maturation # IntAct P0AEV7 2 # InterPro IPR010005 Formate_DH_maturation_HycH # Organism HYCH_ECOLI Escherichia coli (strain K12) # PATRIC 32120836 VBIEscCol129921_2810 # PIR S08626 S08626 # Pfam PF07450 HycH # ProDom PD021295 HycH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HYCH_ECOLI Formate hydrogenlyase maturation protein HycH # RefSeq NP_417198 NC_000913.3 # RefSeq WP_001291921 NZ_LN832404.1 # SIMILARITY To E.coli HyfJ. {ECO 0000305}. # eggNOG ENOG4105I6X Bacteria # eggNOG ENOG4111Q8X LUCA BLAST swissprot:HYCH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HYCH_ECOLI BioCyc ECOL316407:JW2688-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2688-MONOMER BioCyc EcoCyc:EG10481-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10481-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1990.tb00590.x http://dx.doi.org/10.1111/j.1365-2958.1990.tb00590.x DOI 10.1111/j.1365-2958.1992.tb00873.x http://dx.doi.org/10.1111/j.1365-2958.1992.tb00873.x DOI 10.1111/j.1432-1033.1995.tb20422.x http://dx.doi.org/10.1111/j.1432-1033.1995.tb20422.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EMBL X17506 http://www.ebi.ac.uk/ena/data/view/X17506 EchoBASE EB0476 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0476 EcoGene EG10481 http://www.ecogene.org/geneInfo.php?eg_id=EG10481 EnsemblBacteria AAC75760 http://www.ensemblgenomes.org/id/AAC75760 EnsemblBacteria AAC75760 http://www.ensemblgenomes.org/id/AAC75760 EnsemblBacteria BAE76795 http://www.ensemblgenomes.org/id/BAE76795 EnsemblBacteria BAE76795 http://www.ensemblgenomes.org/id/BAE76795 EnsemblBacteria BAE76795 http://www.ensemblgenomes.org/id/BAE76795 EnsemblBacteria b2718 http://www.ensemblgenomes.org/id/b2718 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 GOslim_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 GeneID 947438 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947438 HOGENOM HOG000278708 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278708&db=HOGENOM6 IntAct P0AEV7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEV7* InterPro IPR010005 http://www.ebi.ac.uk/interpro/entry/IPR010005 KEGG_Gene ecj:JW2688 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2688 KEGG_Gene eco:b2718 http://www.genome.jp/dbget-bin/www_bget?eco:b2718 KEGG_Orthology KO:K15834 http://www.genome.jp/dbget-bin/www_bget?KO:K15834 OMA YLMVRRH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YLMVRRH PSORT swissprot:HYCH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HYCH_ECOLI PSORT-B swissprot:HYCH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HYCH_ECOLI PSORT2 swissprot:HYCH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HYCH_ECOLI Pfam PF07450 http://pfam.xfam.org/family/PF07450 Phobius swissprot:HYCH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HYCH_ECOLI ProteinModelPortal P0AEV7 http://www.proteinmodelportal.org/query/uniprot/P0AEV7 PubMed 1625581 http://www.ncbi.nlm.nih.gov/pubmed/1625581 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2187144 http://www.ncbi.nlm.nih.gov/pubmed/2187144 PubMed 7851435 http://www.ncbi.nlm.nih.gov/pubmed/7851435 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417198 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417198 RefSeq WP_001291921 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001291921 STRING 511145.b2718 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2718&targetmode=cogs UniProtKB HYCH_ECOLI http://www.uniprot.org/uniprot/HYCH_ECOLI UniProtKB-AC P0AEV7 http://www.uniprot.org/uniprot/P0AEV7 charge swissprot:HYCH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HYCH_ECOLI eggNOG ENOG4105I6X http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105I6X eggNOG ENOG4111Q8X http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111Q8X epestfind swissprot:HYCH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HYCH_ECOLI garnier swissprot:HYCH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HYCH_ECOLI helixturnhelix swissprot:HYCH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HYCH_ECOLI hmoment swissprot:HYCH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HYCH_ECOLI iep swissprot:HYCH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HYCH_ECOLI inforesidue swissprot:HYCH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HYCH_ECOLI octanol swissprot:HYCH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HYCH_ECOLI pepcoil swissprot:HYCH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HYCH_ECOLI pepdigest swissprot:HYCH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HYCH_ECOLI pepinfo swissprot:HYCH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HYCH_ECOLI pepnet swissprot:HYCH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HYCH_ECOLI pepstats swissprot:HYCH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HYCH_ECOLI pepwheel swissprot:HYCH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HYCH_ECOLI pepwindow swissprot:HYCH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HYCH_ECOLI sigcleave swissprot:HYCH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HYCH_ECOLI ## Database ID URL or Descriptions # AltName SYW_ECOLI Tryptophanyl-tRNA synthetase # BioGrid 4259293 156 # CATALYTIC ACTIVITY SYW_ECOLI ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp). # CDD cd00806 TrpRS_core # EcoGene EG11030 trpS # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004830 tryptophan-tRNA ligase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006436 tryptophanyl-tRNA aminoacylation; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0006520 cellular amino acid metabolic process # Gene3D 3.40.50.620 -; 1. # HAMAP MF_00140_B Trp_tRNA_synth_B # IntAct P00954 12 # InterPro IPR001412 aa-tRNA-synth_I_CS # InterPro IPR002305 aa-tRNA-synth_Ic # InterPro IPR002306 Trp-tRNA-ligase # InterPro IPR014729 Rossmann-like_a/b/a_fold # InterPro IPR024109 Trp-tRNA-ligase_bac-type # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01007 Amino acid related enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # KEGG_Pathway ko00970 Aminoacyl-tRNA biosynthesis # Organism SYW_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10055 PTHR10055 # PATRIC 32122200 VBIEscCol129921_3477 # PIR C65133 YWEC # PRINTS PR01039 TRNASYNTHTRP # PROSITE PS00178 AA_TRNA_LIGASE_I # Pfam PF00579 tRNA-synt_1b # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SYW_ECOLI Tryptophan--tRNA ligase # RefSeq NP_417843 NC_000913.3 # RefSeq WP_000165552 NZ_LN832404.1 # SIMILARITY Belongs to the class-I aminoacyl-tRNA synthetase family. {ECO 0000305}. # SUBCELLULAR LOCATION SYW_ECOLI Cytoplasm. # SUBUNIT SYW_ECOLI Homodimer. # TIGRFAMs TIGR00233 trpS # eggNOG COG0180 LUCA # eggNOG ENOG4105C31 Bacteria BLAST swissprot:SYW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SYW_ECOLI BioCyc ECOL316407:JW3347-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3347-MONOMER BioCyc EcoCyc:TRPS-MONOMER http://biocyc.org/getid?id=EcoCyc:TRPS-MONOMER BioCyc MetaCyc:TRPS-MONOMER http://biocyc.org/getid?id=MetaCyc:TRPS-MONOMER COG COG0180 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0180 DIP DIP-11042N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11042N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1007/BF00290345 http://dx.doi.org/10.1007/BF00290345 DOI 10.1016/0014-5793(77)80618-2 http://dx.doi.org/10.1016/0014-5793(77)80618-2 DOI 10.1021/bi952103d http://dx.doi.org/10.1021/bi952103d DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.1.1.2 http://www.genome.jp/dbget-bin/www_bget?EC:6.1.1.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL U38647 http://www.ebi.ac.uk/ena/data/view/U38647 EMBL V00371 http://www.ebi.ac.uk/ena/data/view/V00371 EMBL Z19601 http://www.ebi.ac.uk/ena/data/view/Z19601 ENZYME 6.1.1.2 http://enzyme.expasy.org/EC/6.1.1.2 EchoBASE EB1023 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1023 EcoGene EG11030 http://www.ecogene.org/geneInfo.php?eg_id=EG11030 EnsemblBacteria AAC76409 http://www.ensemblgenomes.org/id/AAC76409 EnsemblBacteria AAC76409 http://www.ensemblgenomes.org/id/AAC76409 EnsemblBacteria BAE77907 http://www.ensemblgenomes.org/id/BAE77907 EnsemblBacteria BAE77907 http://www.ensemblgenomes.org/id/BAE77907 EnsemblBacteria BAE77907 http://www.ensemblgenomes.org/id/BAE77907 EnsemblBacteria b3384 http://www.ensemblgenomes.org/id/b3384 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004830 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004830 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006436 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006436 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 GeneID 947894 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947894 HAMAP MF_00140_B http://hamap.expasy.org/unirule/MF_00140_B HOGENOM HOG000059940 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000059940&db=HOGENOM6 InParanoid P00954 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00954 IntAct P00954 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00954* IntEnz 6.1.1.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.1.1.2 InterPro IPR001412 http://www.ebi.ac.uk/interpro/entry/IPR001412 InterPro IPR002305 http://www.ebi.ac.uk/interpro/entry/IPR002305 InterPro IPR002306 http://www.ebi.ac.uk/interpro/entry/IPR002306 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 InterPro IPR024109 http://www.ebi.ac.uk/interpro/entry/IPR024109 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW3347 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3347 KEGG_Gene eco:b3384 http://www.genome.jp/dbget-bin/www_bget?eco:b3384 KEGG_Orthology KO:K01867 http://www.genome.jp/dbget-bin/www_bget?KO:K01867 KEGG_Pathway ko00970 http://www.genome.jp/kegg-bin/show_pathway?ko00970 KEGG_Reaction rn:R03664 http://www.genome.jp/dbget-bin/www_bget?rn:R03664 MINT MINT-1244806 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1244806 OMA GWGQFKP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GWGQFKP PANTHER PTHR10055 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10055 PRINTS PR01039 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01039 PROSITE PS00178 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00178 PSORT swissprot:SYW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SYW_ECOLI PSORT-B swissprot:SYW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SYW_ECOLI PSORT2 swissprot:SYW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SYW_ECOLI Pfam PF00579 http://pfam.xfam.org/family/PF00579 Phobius swissprot:SYW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SYW_ECOLI PhylomeDB P00954 http://phylomedb.org/?seqid=P00954 ProteinModelPortal P00954 http://www.proteinmodelportal.org/query/uniprot/P00954 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 334569 http://www.ncbi.nlm.nih.gov/pubmed/334569 PubMed 6171561 http://www.ncbi.nlm.nih.gov/pubmed/6171561 PubMed 7042706 http://www.ncbi.nlm.nih.gov/pubmed/7042706 PubMed 7603433 http://www.ncbi.nlm.nih.gov/pubmed/7603433 PubMed 8555191 http://www.ncbi.nlm.nih.gov/pubmed/8555191 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417843 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417843 RefSeq WP_000165552 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000165552 SMR P00954 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00954 STRING 511145.b3384 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3384&targetmode=cogs STRING COG0180 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0180&targetmode=cogs TIGRFAMs TIGR00233 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00233 UniProtKB SYW_ECOLI http://www.uniprot.org/uniprot/SYW_ECOLI UniProtKB-AC P00954 http://www.uniprot.org/uniprot/P00954 charge swissprot:SYW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SYW_ECOLI eggNOG COG0180 http://eggnogapi.embl.de/nog_data/html/tree/COG0180 eggNOG ENOG4105C31 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C31 epestfind swissprot:SYW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SYW_ECOLI garnier swissprot:SYW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SYW_ECOLI helixturnhelix swissprot:SYW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SYW_ECOLI hmoment swissprot:SYW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SYW_ECOLI iep swissprot:SYW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SYW_ECOLI inforesidue swissprot:SYW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SYW_ECOLI octanol swissprot:SYW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SYW_ECOLI pepcoil swissprot:SYW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SYW_ECOLI pepdigest swissprot:SYW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SYW_ECOLI pepinfo swissprot:SYW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SYW_ECOLI pepnet swissprot:SYW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SYW_ECOLI pepstats swissprot:SYW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SYW_ECOLI pepwheel swissprot:SYW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SYW_ECOLI pepwindow swissprot:SYW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SYW_ECOLI sigcleave swissprot:SYW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SYW_ECOLI ## Database ID URL or Descriptions # BioGrid 4260239 7 # EcoGene EG14388 ynfN # INDUCTION Transiently induced by cold shock. {ECO:0000269|PubMed 14527658}. # Organism YNFN_ECOLI Escherichia coli (strain K12) # PIR B64910 B64910 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNFN_ECOLI Uncharacterized protein YnfN # RefSeq NP_416069 NC_000913.3 # eggNOG ENOG4106IAW Bacteria # eggNOG ENOG410Y031 LUCA BLAST swissprot:YNFN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNFN_ECOLI BioCyc ECOL316407:JW5254-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5254-MONOMER BioCyc EcoCyc:G6824-MONOMER http://biocyc.org/getid?id=EcoCyc:G6824-MONOMER DOI 10.1016/S0923-2508(03)00167-0 http://dx.doi.org/10.1016/S0923-2508(03)00167-0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4131 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4131 EcoGene EG14388 http://www.ecogene.org/geneInfo.php?eg_id=EG14388 EnsemblBacteria AAC74624 http://www.ensemblgenomes.org/id/AAC74624 EnsemblBacteria AAC74624 http://www.ensemblgenomes.org/id/AAC74624 EnsemblBacteria BAE76467 http://www.ensemblgenomes.org/id/BAE76467 EnsemblBacteria BAE76467 http://www.ensemblgenomes.org/id/BAE76467 EnsemblBacteria BAE76467 http://www.ensemblgenomes.org/id/BAE76467 EnsemblBacteria b1551 http://www.ensemblgenomes.org/id/b1551 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946097 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946097 HOGENOM HOG000127719 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000127719&db=HOGENOM6 KEGG_Gene ecj:JW5254 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5254 KEGG_Gene eco:b1551 http://www.genome.jp/dbget-bin/www_bget?eco:b1551 PSORT swissprot:YNFN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNFN_ECOLI PSORT-B swissprot:YNFN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNFN_ECOLI PSORT2 swissprot:YNFN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNFN_ECOLI Phobius swissprot:YNFN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNFN_ECOLI ProteinModelPortal P76157 http://www.proteinmodelportal.org/query/uniprot/P76157 PubMed 14527658 http://www.ncbi.nlm.nih.gov/pubmed/14527658 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416069 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416069 SMR P76157 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76157 STRING 511145.b1551 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1551&targetmode=cogs UniProtKB YNFN_ECOLI http://www.uniprot.org/uniprot/YNFN_ECOLI UniProtKB-AC P76157 http://www.uniprot.org/uniprot/P76157 charge swissprot:YNFN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNFN_ECOLI eggNOG ENOG4106IAW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106IAW eggNOG ENOG410Y031 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y031 epestfind swissprot:YNFN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNFN_ECOLI garnier swissprot:YNFN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNFN_ECOLI helixturnhelix swissprot:YNFN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNFN_ECOLI hmoment swissprot:YNFN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNFN_ECOLI iep swissprot:YNFN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNFN_ECOLI inforesidue swissprot:YNFN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNFN_ECOLI octanol swissprot:YNFN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNFN_ECOLI pepcoil swissprot:YNFN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNFN_ECOLI pepdigest swissprot:YNFN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNFN_ECOLI pepinfo swissprot:YNFN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNFN_ECOLI pepnet swissprot:YNFN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNFN_ECOLI pepstats swissprot:YNFN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNFN_ECOLI pepwheel swissprot:YNFN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNFN_ECOLI pepwindow swissprot:YNFN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNFN_ECOLI sigcleave swissprot:YNFN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNFN_ECOLI ## Database ID URL or Descriptions # BRENDA 4.2.1.20 2026 # BioGrid 4259543 9 # CATALYTIC ACTIVITY TRPB_ECOLI L-serine + 1-C-(indol-3-yl)glycerol 3- phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H(2)O. # CDD cd06446 Trp-synth_B # COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI 597326; # EcoGene EG11025 trpB # FUNCTION TRPB_ECOLI The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004834 tryptophan synthase activity; IDA:EcoCyc. # GO_function GO:0030170 pyridoxal phosphate binding; IDA:EcoliWiki. # GO_function GO:0042802 identical protein binding; IPI:IntAct. # GO_process GO:0000162 tryptophan biosynthetic process; IMP:EcoliWiki. # GO_process GO:0008652 cellular amino acid biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0009073 aromatic amino acid family biosynthetic process; IMP:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # HAMAP MF_00133 Trp_synth_beta # INTERACTION TRPB_ECOLI Self; NbExp=2; IntAct=EBI-1123130, EBI-1123130; # IntAct P0A879 8 # InterPro IPR001926 TrpB-like_PLP-dep # InterPro IPR006653 Trp_synth_b_CS # InterPro IPR006654 Trp_synth_beta # InterPro IPR023026 Trp_synth_beta/beta-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00260 Glycine, serine and threonine metabolism # KEGG_Pathway ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis # Organism TRPB_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-tryptophan biosynthesis; L- tryptophan from chorismate step 5/5. # PATRIC 32117782 VBIEscCol129921_1311 # PDB 2DH5 X-ray; 2.90 A; A=1-397 # PDB 2DH6 X-ray; 3.00 A; A=1-397 # PIR H64873 TSECB # PIRSF PIRSF001413 Trp_syn_beta # PROSITE PS00168 TRP_SYNTHASE_BETA # Pfam PF00291 PALP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TRPB_ECOLI Tryptophan synthase beta chain # RefSeq NP_415777 NC_000913.3 # RefSeq WP_000209520 NZ_LN832404.1 # SIMILARITY Belongs to the TrpB family. {ECO 0000305}. # SUBUNIT TRPB_ECOLI Tetramer of two alpha and two beta chains. # SUPFAM SSF53686 SSF53686 # TIGRFAMs TIGR00263 trpB # UniPathway UPA00035 UER00044 # eggNOG COG0133 LUCA # eggNOG ENOG4105CG0 Bacteria BLAST swissprot:TRPB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRPB_ECOLI BioCyc ECOL316407:JW1253-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1253-MONOMER BioCyc EcoCyc:TRYPSYN-BPROTEIN http://biocyc.org/getid?id=EcoCyc:TRYPSYN-BPROTEIN BioCyc MetaCyc:TRYPSYN-BPROTEIN http://biocyc.org/getid?id=MetaCyc:TRYPSYN-BPROTEIN COG COG0133 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0133 DIP DIP-1036N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-1036N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1016/0022-2836(80)90259-4 http://dx.doi.org/10.1016/0022-2836(80)90259-4 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/9.24.6647 http://dx.doi.org/10.1093/nar/9.24.6647 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.1.20 http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.20 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01714 http://www.ebi.ac.uk/ena/data/view/J01714 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U23489 http://www.ebi.ac.uk/ena/data/view/U23489 EMBL U23490 http://www.ebi.ac.uk/ena/data/view/U23490 EMBL U23492 http://www.ebi.ac.uk/ena/data/view/U23492 EMBL U23493 http://www.ebi.ac.uk/ena/data/view/U23493 EMBL U23500 http://www.ebi.ac.uk/ena/data/view/U23500 EMBL U25417 http://www.ebi.ac.uk/ena/data/view/U25417 EMBL U25418 http://www.ebi.ac.uk/ena/data/view/U25418 EMBL U25419 http://www.ebi.ac.uk/ena/data/view/U25419 EMBL U25422 http://www.ebi.ac.uk/ena/data/view/U25422 EMBL U25423 http://www.ebi.ac.uk/ena/data/view/U25423 EMBL U25426 http://www.ebi.ac.uk/ena/data/view/U25426 EMBL U25427 http://www.ebi.ac.uk/ena/data/view/U25427 EMBL U25428 http://www.ebi.ac.uk/ena/data/view/U25428 EMBL U25429 http://www.ebi.ac.uk/ena/data/view/U25429 EMBL V00365 http://www.ebi.ac.uk/ena/data/view/V00365 EMBL V00372 http://www.ebi.ac.uk/ena/data/view/V00372 ENZYME 4.2.1.20 http://enzyme.expasy.org/EC/4.2.1.20 EchoBASE EB1018 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1018 EcoGene EG11025 http://www.ecogene.org/geneInfo.php?eg_id=EG11025 EnsemblBacteria AAC74343 http://www.ensemblgenomes.org/id/AAC74343 EnsemblBacteria AAC74343 http://www.ensemblgenomes.org/id/AAC74343 EnsemblBacteria BAA14793 http://www.ensemblgenomes.org/id/BAA14793 EnsemblBacteria BAA14793 http://www.ensemblgenomes.org/id/BAA14793 EnsemblBacteria BAA14793 http://www.ensemblgenomes.org/id/BAA14793 EnsemblBacteria b1261 http://www.ensemblgenomes.org/id/b1261 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004834 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004834 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0000162 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000162 GO_process GO:0008652 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008652 GO_process GO:0009073 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009073 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 945768 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945768 HAMAP MF_00133 http://hamap.expasy.org/unirule/MF_00133 HOGENOM HOG000161710 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000161710&db=HOGENOM6 InParanoid P0A879 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A879 IntAct P0A879 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A879* IntEnz 4.2.1.20 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.20 InterPro IPR001926 http://www.ebi.ac.uk/interpro/entry/IPR001926 InterPro IPR006653 http://www.ebi.ac.uk/interpro/entry/IPR006653 InterPro IPR006654 http://www.ebi.ac.uk/interpro/entry/IPR006654 InterPro IPR023026 http://www.ebi.ac.uk/interpro/entry/IPR023026 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1253 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1253 KEGG_Gene eco:b1261 http://www.genome.jp/dbget-bin/www_bget?eco:b1261 KEGG_Orthology KO:K01696 http://www.genome.jp/dbget-bin/www_bget?KO:K01696 KEGG_Pathway ko00260 http://www.genome.jp/kegg-bin/show_pathway?ko00260 KEGG_Pathway ko00400 http://www.genome.jp/kegg-bin/show_pathway?ko00400 KEGG_Reaction rn:R00674 http://www.genome.jp/dbget-bin/www_bget?rn:R00674 KEGG_Reaction rn:R02340 http://www.genome.jp/dbget-bin/www_bget?rn:R02340 KEGG_Reaction rn:R02722 http://www.genome.jp/dbget-bin/www_bget?rn:R02722 MINT MINT-7711989 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-7711989 OMA CQKEGII http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CQKEGII PDB 2DH5 http://www.ebi.ac.uk/pdbe-srv/view/entry/2DH5 PDB 2DH6 http://www.ebi.ac.uk/pdbe-srv/view/entry/2DH6 PDBsum 2DH5 http://www.ebi.ac.uk/pdbsum/2DH5 PDBsum 2DH6 http://www.ebi.ac.uk/pdbsum/2DH6 PROSITE PS00168 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00168 PSORT swissprot:TRPB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRPB_ECOLI PSORT-B swissprot:TRPB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRPB_ECOLI PSORT2 swissprot:TRPB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRPB_ECOLI Pfam PF00291 http://pfam.xfam.org/family/PF00291 Phobius swissprot:TRPB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRPB_ECOLI PhylomeDB P0A879 http://phylomedb.org/?seqid=P0A879 ProteinModelPortal P0A879 http://www.proteinmodelportal.org/query/uniprot/P0A879 PubMed 1309752 http://www.ncbi.nlm.nih.gov/pubmed/1309752 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 4552018 http://www.ncbi.nlm.nih.gov/pubmed/4552018 PubMed 4943677 http://www.ncbi.nlm.nih.gov/pubmed/4943677 PubMed 6985892 http://www.ncbi.nlm.nih.gov/pubmed/6985892 PubMed 7007651 http://www.ncbi.nlm.nih.gov/pubmed/7007651 PubMed 7038627 http://www.ncbi.nlm.nih.gov/pubmed/7038627 PubMed 8095913 http://www.ncbi.nlm.nih.gov/pubmed/8095913 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_415777 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415777 RefSeq WP_000209520 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000209520 SMR P0A879 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A879 STRING 511145.b1261 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1261&targetmode=cogs STRING COG0133 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0133&targetmode=cogs SUPFAM SSF53686 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53686 SWISS-2DPAGE P0A879 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A879 TIGRFAMs TIGR00263 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00263 UniProtKB TRPB_ECOLI http://www.uniprot.org/uniprot/TRPB_ECOLI UniProtKB-AC P0A879 http://www.uniprot.org/uniprot/P0A879 charge swissprot:TRPB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRPB_ECOLI eggNOG COG0133 http://eggnogapi.embl.de/nog_data/html/tree/COG0133 eggNOG ENOG4105CG0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CG0 epestfind swissprot:TRPB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRPB_ECOLI garnier swissprot:TRPB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRPB_ECOLI helixturnhelix swissprot:TRPB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRPB_ECOLI hmoment swissprot:TRPB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRPB_ECOLI iep swissprot:TRPB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRPB_ECOLI inforesidue swissprot:TRPB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRPB_ECOLI octanol swissprot:TRPB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRPB_ECOLI pepcoil swissprot:TRPB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRPB_ECOLI pepdigest swissprot:TRPB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRPB_ECOLI pepinfo swissprot:TRPB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRPB_ECOLI pepnet swissprot:TRPB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRPB_ECOLI pepstats swissprot:TRPB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRPB_ECOLI pepwheel swissprot:TRPB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRPB_ECOLI pepwindow swissprot:TRPB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRPB_ECOLI sigcleave swissprot:TRPB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRPB_ECOLI ## Database ID URL or Descriptions # AltName BAMA_ECOLI Omp85 # BioGrid 4259504 679 # DISRUPTION PHENOTYPE BAMA_ECOLI Deletion is lethal. Depletion results in the accumulation of incorrectly assembled outer membrane proteins, including TolC, OmpF, OmpC and OmpA (PubMed 15851030, PubMed 16102012). Decreased expression leads to decreased susceptibility to contact-dependent growth inhibition (CDI), and decreased expression of outer membrane proteins (including in this study LamB) as well as up-regulation of periplasmic protease DegP (PubMed 18761695, PubMed 23469034). {ECO 0000269|PubMed 15851030, ECO 0000269|PubMed 16102012, ECO 0000269|PubMed 18761695, ECO 0000269|PubMed 23469034}. # DOMAIN BAMA_ECOLI Contains 5 N-terminal periplasmic polypeptide transport- associated (POTRA) domains which interact with other subunits of the complex, may recruit substrates from the periplasm into the outer membrane and also act as a chaperone (PubMed 17702946, PubMed 18430136, PubMed 19081063, PubMed 21795783, PubMed 14559180). The C-terminal region forms a discontinuous 16- stranded beta-barrel transmembrane region. The central pore is ellipsoid, and probably closed by extracellular loop 6, perhaps with the aid of other loops (PubMed 24914988, PubMed 24619089). {ECO 0000269|PubMed 17702946, ECO 0000269|PubMed 18430136, ECO 0000269|PubMed 19081063, ECO 0000269|PubMed 21795783, ECO 0000269|PubMed 24619089, ECO 0000269|PubMed 24914988, ECO 0000305|PubMed 14559180}. # EcoGene EG12676 bamA # FUNCTION BAMA_ECOLI Acts as a receptor for CdiA-EC93, the contact-dependent growth inhibition (CDI) effector of E.coli strain EC93; antibodies against extracellular epitopes decrease CDI. Its role in CDI is independent of the other Bam complex components (PubMed 18761695). Also acts as a receptor for CDI with CdiA from E.coli strain 536 / UPEC, which does not have the same mode of toxicity as CdiA from strain EC93 (PubMed 23469034, PubMed 23882017). Susceptibility to CdiA-EC93 is dependent on E.coli BamA; replacing BamA with the gene from S.typhimurium LT2, E.cloacae ATCC 13047 or D.dadantii 3937 renders cells resistant to CdiA-EC93. Cells with BamA from another bacteria no longer form CdiA-EC93-induced aggregates with EC93 cells. A chimera in which E.cloacae extracellular loops 6 and 7 are replaced with loops 6 and 7 from E.coli is susceptible to CdiA-EC93 and to CdiA-CT from strain 536 / UPEC (PubMed 23882017). {ECO 0000269|PubMed 18761695, ECO 0000269|PubMed 23469034, ECO 0000269|PubMed 23882017}. # FUNCTION BAMA_ECOLI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery. {ECO 0000255|HAMAP- Rule MF_01430, ECO 0000269|PubMed 15951436, ECO 0000269|PubMed 16102012, ECO 0000269|PubMed 16824102, ECO 0000269|PubMed 20378773, ECO 0000269|PubMed 21823654}. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_component GO:1990063 Bam protein complex; IDA:EcoCyc. # GO_process GO:0007155 cell adhesion; IEA:UniProtKB-KW. # GO_process GO:0043165 Gram-negative-bacterium-type cell outer membrane assembly; IDA:EcoCyc. # GO_process GO:0051205 protein insertion into membrane; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043234 protein complex # GOslim_process GO:0007155 cell adhesion # GOslim_process GO:0008150 biological_process # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0061024 membrane organization # HAMAP MF_01430 OM_assembly_BamA # INTERACTION BAMA_ECOLI P77774 bamB; NbExp=16; IntAct=EBI-907371, EBI-907297; P0AC02 bamD; NbExp=13; IntAct=EBI-907371, EBI-1128087; P69411 rcsF; NbExp=3; IntAct=EBI-907371, EBI-1114706; # IntAct P0A940 14 # InterPro IPR000184 Bac_surfAg_D15 # InterPro IPR010827 Surface_Ag_variable_number # InterPro IPR023707 OM_assembly_BamA # Organism BAMA_ECOLI Escherichia coli (strain K12) # PATRIC 32115465 VBIEscCol129921_0184 # PDB 2QCZ X-ray; 2.70 A; A/B=21-351 # PDB 2QDF X-ray; 2.20 A; A=21-351 # PDB 2V9H NMR; -; A=21-174 # PDB 3EFC X-ray; 3.30 A; A=21-410 # PDB 3OG5 X-ray; 2.69 A; A/B=264-424 # PDB 3Q6B X-ray; 1.50 A; A=266-420 # PDB 4C4V X-ray; 3.00 A; A=347-810, B=344-810 # PDB 4N75 X-ray; 2.60 A; A/B=427-810 # PDB 4PK1 X-ray; 3.10 A; A=175-424 # PDB 4XGA X-ray; 2.15 A; B=175-420 # PDB 5AYW X-ray; 3.56 A; A=22-810 # PDB 5D0O X-ray; 2.90 A; A=1-810 # PDB 5D0Q X-ray; 3.50 A; A/F=1-810 # PDB 5EKQ X-ray; 3.39 A; A=21-810 # PIR A64742 A64742 # PIRSF PIRSF006076 OM_assembly_OMP85 # PROSITE PS51779 POTRA; 5 # Pfam PF01103 Bac_surface_Ag # Pfam PF07244 POTRA; 4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Outer membrane protein assembly factor BamA {ECO:0000255|HAMAP-Rule MF_01430} # RefSeq NP_414719 NC_000913.3 # RefSeq WP_001240896 NZ_LN832404.1 # SIMILARITY Belongs to the BamA family. {ECO:0000255|HAMAP- Rule MF_01430}. # SIMILARITY Contains 5 POTRA domains. {ECO:0000255|PROSITE- ProRule PRU01115}. # SUBCELLULAR LOCATION BAMA_ECOLI Cell outer membrane {ECO 0000255|HAMAP- Rule MF_01430, ECO 0000269|PubMed 16079137, ECO 0000269|PubMed 23882017, ECO 0000269|PubMed 24619089, ECO 0000269|PubMed 24914988}. # SUBUNIT BAMA_ECOLI Part of the Bam complex, which is composed of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE. BamA interacts directly with BamB and the BamCDE subcomplex. {ECO 0000255|HAMAP-Rule MF_01430, ECO 0000269|PubMed 15851030, ECO 0000269|PubMed 16079137, ECO 0000269|PubMed 16824102, ECO 0000269|PubMed 17404237, ECO 0000269|PubMed 20378773, ECO 0000269|PubMed 21586578, ECO 0000269|PubMed 21823654}. # TIGRFAMs TIGR03303 OM_YaeT # eggNOG COG4775 LUCA # eggNOG ENOG4105E1Z Bacteria BLAST swissprot:BAMA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BAMA_ECOLI BioCyc ECOL316407:JW0172-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0172-MONOMER BioCyc EcoCyc:G6093-MONOMER http://biocyc.org/getid?id=EcoCyc:G6093-MONOMER COG COG4775 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4775 DIP DIP-36019N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36019N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1016/j.cell.2005.02.015 http://dx.doi.org/10.1016/j.cell.2005.02.015 DOI 10.1016/j.str.2008.09.014 http://dx.doi.org/10.1016/j.str.2008.09.014 DOI 10.1016/j.tibs.2003.08.003 http://dx.doi.org/10.1016/j.tibs.2003.08.003 DOI 10.1021/bi2010784 http://dx.doi.org/10.1021/bi2010784 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0701579104 http://dx.doi.org/10.1073/pnas.0701579104 DOI 10.1074/jbc.M100464200 http://dx.doi.org/10.1074/jbc.M100464200 DOI 10.1074/jbc.M111.238931 http://dx.doi.org/10.1074/jbc.M111.238931 DOI 10.1074/jbc.M504796200 http://dx.doi.org/10.1074/jbc.M504796200 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1096/fj.13-248450 http://dx.doi.org/10.1096/fj.13-248450 DOI 10.1107/S1399004714007482 http://dx.doi.org/10.1107/S1399004714007482 DOI 10.1107/S1744309111014254 http://dx.doi.org/10.1107/S1744309111014254 DOI 10.1111/j.1365-2958.2005.04775.x http://dx.doi.org/10.1111/j.1365-2958.2005.04775.x DOI 10.1111/j.1365-2958.2006.05211.x http://dx.doi.org/10.1111/j.1365-2958.2006.05211.x DOI 10.1111/j.1365-2958.2008.06225.x http://dx.doi.org/10.1111/j.1365-2958.2008.06225.x DOI 10.1111/j.1365-2958.2008.06404.x http://dx.doi.org/10.1111/j.1365-2958.2008.06404.x DOI 10.1126/science.1143993 http://dx.doi.org/10.1126/science.1143993 DOI 10.1126/science.1188919 http://dx.doi.org/10.1126/science.1188919 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/mBio.00480-13 http://dx.doi.org/10.1128/mBio.00480-13 DOI 10.1371/journal.pone.0057609 http://dx.doi.org/10.1371/journal.pone.0057609 EMBL AF407013 http://www.ebi.ac.uk/ena/data/view/AF407013 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL AY035865 http://www.ebi.ac.uk/ena/data/view/AY035865 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EchoBASE EB2541 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2541 EcoGene EG12676 http://www.ecogene.org/geneInfo.php?eg_id=EG12676 EnsemblBacteria AAC73288 http://www.ensemblgenomes.org/id/AAC73288 EnsemblBacteria AAC73288 http://www.ensemblgenomes.org/id/AAC73288 EnsemblBacteria BAA77852 http://www.ensemblgenomes.org/id/BAA77852 EnsemblBacteria BAA77852 http://www.ensemblgenomes.org/id/BAA77852 EnsemblBacteria BAA77852 http://www.ensemblgenomes.org/id/BAA77852 EnsemblBacteria b0177 http://www.ensemblgenomes.org/id/b0177 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:1990063 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990063 GO_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GO_process GO:0043165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043165 GO_process GO:0051205 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051205 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0061024 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024 GeneID 944870 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944870 HAMAP MF_01430 http://hamap.expasy.org/unirule/MF_01430 InParanoid P0A940 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A940 IntAct P0A940 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A940* InterPro IPR000184 http://www.ebi.ac.uk/interpro/entry/IPR000184 InterPro IPR010827 http://www.ebi.ac.uk/interpro/entry/IPR010827 InterPro IPR023707 http://www.ebi.ac.uk/interpro/entry/IPR023707 KEGG_Gene ecj:JW0172 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0172 KEGG_Gene eco:b0177 http://www.genome.jp/dbget-bin/www_bget?eco:b0177 KEGG_Orthology KO:K07277 http://www.genome.jp/dbget-bin/www_bget?KO:K07277 OMA GYFPTKG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GYFPTKG PDB 2QCZ http://www.ebi.ac.uk/pdbe-srv/view/entry/2QCZ PDB 2QDF http://www.ebi.ac.uk/pdbe-srv/view/entry/2QDF PDB 2V9H http://www.ebi.ac.uk/pdbe-srv/view/entry/2V9H PDB 3EFC http://www.ebi.ac.uk/pdbe-srv/view/entry/3EFC PDB 3OG5 http://www.ebi.ac.uk/pdbe-srv/view/entry/3OG5 PDB 3Q6B http://www.ebi.ac.uk/pdbe-srv/view/entry/3Q6B PDB 4C4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4C4V PDB 4N75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4N75 PDB 4PK1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4PK1 PDB 4XGA http://www.ebi.ac.uk/pdbe-srv/view/entry/4XGA PDB 5AYW http://www.ebi.ac.uk/pdbe-srv/view/entry/5AYW PDB 5D0O http://www.ebi.ac.uk/pdbe-srv/view/entry/5D0O PDB 5D0Q http://www.ebi.ac.uk/pdbe-srv/view/entry/5D0Q PDB 5EKQ http://www.ebi.ac.uk/pdbe-srv/view/entry/5EKQ PDBsum 2QCZ http://www.ebi.ac.uk/pdbsum/2QCZ PDBsum 2QDF http://www.ebi.ac.uk/pdbsum/2QDF PDBsum 2V9H http://www.ebi.ac.uk/pdbsum/2V9H PDBsum 3EFC http://www.ebi.ac.uk/pdbsum/3EFC PDBsum 3OG5 http://www.ebi.ac.uk/pdbsum/3OG5 PDBsum 3Q6B http://www.ebi.ac.uk/pdbsum/3Q6B PDBsum 4C4V http://www.ebi.ac.uk/pdbsum/4C4V PDBsum 4N75 http://www.ebi.ac.uk/pdbsum/4N75 PDBsum 4PK1 http://www.ebi.ac.uk/pdbsum/4PK1 PDBsum 4XGA http://www.ebi.ac.uk/pdbsum/4XGA PDBsum 5AYW http://www.ebi.ac.uk/pdbsum/5AYW PDBsum 5D0O http://www.ebi.ac.uk/pdbsum/5D0O PDBsum 5D0Q http://www.ebi.ac.uk/pdbsum/5D0Q PDBsum 5EKQ http://www.ebi.ac.uk/pdbsum/5EKQ PROSITE PS51779 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51779 PSORT swissprot:BAMA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BAMA_ECOLI PSORT-B swissprot:BAMA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BAMA_ECOLI PSORT2 swissprot:BAMA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BAMA_ECOLI Pfam PF01103 http://pfam.xfam.org/family/PF01103 Pfam PF07244 http://pfam.xfam.org/family/PF07244 Phobius swissprot:BAMA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BAMA_ECOLI PhylomeDB P0A940 http://phylomedb.org/?seqid=P0A940 ProteinModelPortal P0A940 http://www.proteinmodelportal.org/query/uniprot/P0A940 PubMed 11274153 http://www.ncbi.nlm.nih.gov/pubmed/11274153 PubMed 14559180 http://www.ncbi.nlm.nih.gov/pubmed/14559180 PubMed 15851030 http://www.ncbi.nlm.nih.gov/pubmed/15851030 PubMed 15951436 http://www.ncbi.nlm.nih.gov/pubmed/15951436 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16102012 http://www.ncbi.nlm.nih.gov/pubmed/16102012 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16824102 http://www.ncbi.nlm.nih.gov/pubmed/16824102 PubMed 17404237 http://www.ncbi.nlm.nih.gov/pubmed/17404237 PubMed 17702946 http://www.ncbi.nlm.nih.gov/pubmed/17702946 PubMed 18430136 http://www.ncbi.nlm.nih.gov/pubmed/18430136 PubMed 18761695 http://www.ncbi.nlm.nih.gov/pubmed/18761695 PubMed 19081063 http://www.ncbi.nlm.nih.gov/pubmed/19081063 PubMed 20378773 http://www.ncbi.nlm.nih.gov/pubmed/20378773 PubMed 21586578 http://www.ncbi.nlm.nih.gov/pubmed/21586578 PubMed 21795783 http://www.ncbi.nlm.nih.gov/pubmed/21795783 PubMed 21823654 http://www.ncbi.nlm.nih.gov/pubmed/21823654 PubMed 23469034 http://www.ncbi.nlm.nih.gov/pubmed/23469034 PubMed 23882017 http://www.ncbi.nlm.nih.gov/pubmed/23882017 PubMed 24619089 http://www.ncbi.nlm.nih.gov/pubmed/24619089 PubMed 24914988 http://www.ncbi.nlm.nih.gov/pubmed/24914988 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_414719 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414719 RefSeq WP_001240896 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001240896 SMR P0A940 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A940 STRING 511145.b0177 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0177&targetmode=cogs STRING COG4775 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4775&targetmode=cogs SWISS-2DPAGE P0A940 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A940 TIGRFAMs TIGR03303 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03303 UniProtKB BAMA_ECOLI http://www.uniprot.org/uniprot/BAMA_ECOLI UniProtKB-AC P0A940 http://www.uniprot.org/uniprot/P0A940 charge swissprot:BAMA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BAMA_ECOLI eggNOG COG4775 http://eggnogapi.embl.de/nog_data/html/tree/COG4775 eggNOG ENOG4105E1Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E1Z epestfind swissprot:BAMA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BAMA_ECOLI garnier swissprot:BAMA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BAMA_ECOLI helixturnhelix swissprot:BAMA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BAMA_ECOLI hmoment swissprot:BAMA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BAMA_ECOLI iep swissprot:BAMA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BAMA_ECOLI inforesidue swissprot:BAMA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BAMA_ECOLI octanol swissprot:BAMA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BAMA_ECOLI pepcoil swissprot:BAMA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BAMA_ECOLI pepdigest swissprot:BAMA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BAMA_ECOLI pepinfo swissprot:BAMA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BAMA_ECOLI pepnet swissprot:BAMA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BAMA_ECOLI pepstats swissprot:BAMA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BAMA_ECOLI pepwheel swissprot:BAMA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BAMA_ECOLI pepwindow swissprot:BAMA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BAMA_ECOLI sigcleave swissprot:BAMA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BAMA_ECOLI ## Database ID URL or Descriptions # BioGrid 4263397 17 # DISRUPTION PHENOTYPE No visible effect on transformation or growth in the presence or absence of mitomycin C (in strain KA797), on plasmid conjugation (in strain PC4020), on nucleotide excision repair, survival of UV damage or DNA recombination (PubMed:16978360). {ECO 0000269|PubMed:16978360}. # EcoGene EG11604 smf # FUNCTION SMF_ECOLI Partially complements natural chromosomal DNA transformation defect of an H.influenzae dprA disruption mutant (PubMed 16978360). May help load RecA onto ssDNA (By similarity). {ECO 0000250|UniProtKB Q8DPI7, ECO 0000269|PubMed 16978360}. # GO_process GO:0009294 DNA mediated transformation; IEA:InterPro. # GOslim_process GO:0008150 biological_process # InterPro IPR003488 DprA # Organism SMF_ECOLI Escherichia coli (strain K12) # PATRIC 32122004 VBIEscCol129921_3379 # Pfam PF02481 DNA_processg_A # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SMF_ECOLI Protein Smf # RefSeq WP_000228551 NZ_LN832404.1 # RefSeq YP_026211 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA58082.1; Type=Frameshift; Positions=249; Evidence={ECO:0000305}; Sequence=AAA58083.1; Type=Frameshift; Positions=249; Evidence={ECO 0000305}; # SIMILARITY Belongs to the DprA/Smf family. {ECO 0000305}. # TIGRFAMs TIGR00732 dprA # eggNOG COG0758 LUCA # eggNOG ENOG4105C79 Bacteria BLAST swissprot:SMF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SMF_ECOLI BioCyc ECOL316407:JW5708-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5708-MONOMER BioCyc EcoCyc:EG11604-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11604-MONOMER COG COG0758 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0758 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1111/j.1574-6968.2006.00423.x http://dx.doi.org/10.1111/j.1574-6968.2006.00423.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X65946 http://www.ebi.ac.uk/ena/data/view/X65946 EMBL X77091 http://www.ebi.ac.uk/ena/data/view/X77091 EMBL X77800 http://www.ebi.ac.uk/ena/data/view/X77800 EchoBASE EB1561 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1561 EcoGene EG11604 http://www.ecogene.org/geneInfo.php?eg_id=EG11604 EnsemblBacteria AAT48176 http://www.ensemblgenomes.org/id/AAT48176 EnsemblBacteria AAT48176 http://www.ensemblgenomes.org/id/AAT48176 EnsemblBacteria BAE78006 http://www.ensemblgenomes.org/id/BAE78006 EnsemblBacteria BAE78006 http://www.ensemblgenomes.org/id/BAE78006 EnsemblBacteria BAE78006 http://www.ensemblgenomes.org/id/BAE78006 EnsemblBacteria b4473 http://www.ensemblgenomes.org/id/b4473 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0009294 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009294 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 2847708 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2847708 HOGENOM HOG000003906 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000003906&db=HOGENOM6 InParanoid P30852 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30852 InterPro IPR003488 http://www.ebi.ac.uk/interpro/entry/IPR003488 KEGG_Gene ecj:JW5708 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5708 KEGG_Gene eco:b4473 http://www.genome.jp/dbget-bin/www_bget?eco:b4473 KEGG_Orthology KO:K04096 http://www.genome.jp/dbget-bin/www_bget?KO:K04096 OMA RTNIPVQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RTNIPVQ PSORT swissprot:SMF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SMF_ECOLI PSORT-B swissprot:SMF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SMF_ECOLI PSORT2 swissprot:SMF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SMF_ECOLI Pfam PF02481 http://pfam.xfam.org/family/PF02481 Phobius swissprot:SMF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SMF_ECOLI PhylomeDB P30852 http://phylomedb.org/?seqid=P30852 ProteinModelPortal P30852 http://www.proteinmodelportal.org/query/uniprot/P30852 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16978360 http://www.ncbi.nlm.nih.gov/pubmed/16978360 PubMed 8112305 http://www.ncbi.nlm.nih.gov/pubmed/8112305 PubMed 8432722 http://www.ncbi.nlm.nih.gov/pubmed/8432722 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000228551 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000228551 RefSeq YP_026211 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026211 SMR P30852 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P30852 STRING 511145.b4473 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4473&targetmode=cogs STRING COG0758 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0758&targetmode=cogs TIGRFAMs TIGR00732 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00732 UniProtKB SMF_ECOLI http://www.uniprot.org/uniprot/SMF_ECOLI UniProtKB-AC P30852 http://www.uniprot.org/uniprot/P30852 charge swissprot:SMF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SMF_ECOLI eggNOG COG0758 http://eggnogapi.embl.de/nog_data/html/tree/COG0758 eggNOG ENOG4105C79 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C79 epestfind swissprot:SMF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SMF_ECOLI garnier swissprot:SMF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SMF_ECOLI helixturnhelix swissprot:SMF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SMF_ECOLI hmoment swissprot:SMF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SMF_ECOLI iep swissprot:SMF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SMF_ECOLI inforesidue swissprot:SMF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SMF_ECOLI octanol swissprot:SMF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SMF_ECOLI pepcoil swissprot:SMF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SMF_ECOLI pepdigest swissprot:SMF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SMF_ECOLI pepinfo swissprot:SMF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SMF_ECOLI pepnet swissprot:SMF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SMF_ECOLI pepstats swissprot:SMF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SMF_ECOLI pepwheel swissprot:SMF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SMF_ECOLI pepwindow swissprot:SMF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SMF_ECOLI sigcleave swissprot:SMF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SMF_ECOLI ## Database ID URL or Descriptions # BioGrid 4262226 126 # EcoGene EG11290 yeiB # FUNCTION YEIB_ECOLI Involved in transport. {ECO 0000305}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006810 transport; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006810 transport # InterPro IPR007349 DUF418 # Organism YEIB_ECOLI Escherichia coli (strain K12) # PATRIC 32119651 VBIEscCol129921_2236 # PIR G64983 G64983 # Pfam PF04235 DUF418 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEIB_ECOLI Uncharacterized protein YeiB # RefSeq NP_416657 NC_000913.3 # RefSeq WP_000440926 NZ_CP014272.1 # SIMILARITY To B.subtilis YxaH and YrkO. {ECO 0000305}. # SUBCELLULAR LOCATION YEIB_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # TCDB 9.B.169.1 the integral membrane protein (8 -10 tmss) yeib or duf418 (yeib) family # eggNOG COG2311 LUCA # eggNOG ENOG4105DHF Bacteria BLAST swissprot:YEIB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEIB_ECOLI BioCyc ECOL316407:JW2139-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2139-MONOMER BioCyc EcoCyc:EG11290-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11290-MONOMER COG COG2311 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2311 DOI 10.1016/0022-2836(92)90125-4 http://dx.doi.org/10.1016/0022-2836(92)90125-4 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X62529 http://www.ebi.ac.uk/ena/data/view/X62529 EchoBASE EB1267 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1267 EcoGene EG11290 http://www.ecogene.org/geneInfo.php?eg_id=EG11290 EnsemblBacteria AAC75213 http://www.ensemblgenomes.org/id/AAC75213 EnsemblBacteria AAC75213 http://www.ensemblgenomes.org/id/AAC75213 EnsemblBacteria BAE76629 http://www.ensemblgenomes.org/id/BAE76629 EnsemblBacteria BAE76629 http://www.ensemblgenomes.org/id/BAE76629 EnsemblBacteria BAE76629 http://www.ensemblgenomes.org/id/BAE76629 EnsemblBacteria b2152 http://www.ensemblgenomes.org/id/b2152 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 949044 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949044 HOGENOM HOG000086947 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000086947&db=HOGENOM6 InParanoid P25747 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P25747 InterPro IPR007349 http://www.ebi.ac.uk/interpro/entry/IPR007349 KEGG_Gene ecj:JW2139 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2139 KEGG_Gene eco:b2152 http://www.genome.jp/dbget-bin/www_bget?eco:b2152 KEGG_Orthology KO:K07148 http://www.genome.jp/dbget-bin/www_bget?KO:K07148 OMA ALIYIHI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ALIYIHI PSORT swissprot:YEIB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEIB_ECOLI PSORT-B swissprot:YEIB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEIB_ECOLI PSORT2 swissprot:YEIB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEIB_ECOLI Pfam PF04235 http://pfam.xfam.org/family/PF04235 Phobius swissprot:YEIB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEIB_ECOLI PhylomeDB P25747 http://phylomedb.org/?seqid=P25747 ProteinModelPortal P25747 http://www.proteinmodelportal.org/query/uniprot/P25747 PubMed 1619663 http://www.ncbi.nlm.nih.gov/pubmed/1619663 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416657 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416657 RefSeq WP_000440926 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000440926 STRING 511145.b2152 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2152&targetmode=cogs STRING COG2311 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2311&targetmode=cogs TCDB 9.B.169.1 http://www.tcdb.org/search/result.php?tc=9.B.169.1 UniProtKB YEIB_ECOLI http://www.uniprot.org/uniprot/YEIB_ECOLI UniProtKB-AC P25747 http://www.uniprot.org/uniprot/P25747 charge swissprot:YEIB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEIB_ECOLI eggNOG COG2311 http://eggnogapi.embl.de/nog_data/html/tree/COG2311 eggNOG ENOG4105DHF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DHF epestfind swissprot:YEIB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEIB_ECOLI garnier swissprot:YEIB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEIB_ECOLI helixturnhelix swissprot:YEIB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEIB_ECOLI hmoment swissprot:YEIB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEIB_ECOLI iep swissprot:YEIB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEIB_ECOLI inforesidue swissprot:YEIB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEIB_ECOLI octanol swissprot:YEIB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEIB_ECOLI pepcoil swissprot:YEIB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEIB_ECOLI pepdigest swissprot:YEIB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEIB_ECOLI pepinfo swissprot:YEIB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEIB_ECOLI pepnet swissprot:YEIB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEIB_ECOLI pepstats swissprot:YEIB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEIB_ECOLI pepwheel swissprot:YEIB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEIB_ECOLI pepwindow swissprot:YEIB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEIB_ECOLI sigcleave swissprot:YEIB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEIB_ECOLI ## Database ID URL or Descriptions # EcoGene EG14459 yjbT # InterPro IPR031382 YjbT # Organism YJBT_ECOLI Escherichia coli (strain K12) # Pfam PF17089 YjbT # Proteomes UP000000625 Chromosome # RecName YJBT_ECOLI Uncharacterized protein YjbT # RefSeq WP_001295279 NZ_LN832404.1 # RefSeq YP_001165332 NC_000913.3 # SIMILARITY Belongs to the YjbT family. {ECO 0000305}. BLAST swissprot:YJBT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJBT_ECOLI BioCyc EcoCyc:MONOMER0-2828 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2828 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14459 http://www.ecogene.org/geneInfo.php?eg_id=EG14459 EnsemblBacteria ABP93457 http://www.ensemblgenomes.org/id/ABP93457 EnsemblBacteria ABP93457 http://www.ensemblgenomes.org/id/ABP93457 EnsemblBacteria b4620 http://www.ensemblgenomes.org/id/b4620 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 5061528 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5061528 HOGENOM HOG000009670 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009670&db=HOGENOM6 InterPro IPR031382 http://www.ebi.ac.uk/interpro/entry/IPR031382 KEGG_Gene eco:b4620 http://www.genome.jp/dbget-bin/www_bget?eco:b4620 PSORT swissprot:YJBT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJBT_ECOLI PSORT-B swissprot:YJBT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJBT_ECOLI PSORT2 swissprot:YJBT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJBT_ECOLI Pfam PF17089 http://pfam.xfam.org/family/PF17089 Phobius swissprot:YJBT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJBT_ECOLI ProteinModelPortal A5A628 http://www.proteinmodelportal.org/query/uniprot/A5A628 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001295279 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295279 RefSeq YP_001165332 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001165332 SMR A5A628 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=A5A628 STRING 511145.b4620 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4620&targetmode=cogs UniProtKB YJBT_ECOLI http://www.uniprot.org/uniprot/YJBT_ECOLI UniProtKB-AC A5A628 http://www.uniprot.org/uniprot/A5A628 charge swissprot:YJBT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJBT_ECOLI epestfind swissprot:YJBT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJBT_ECOLI garnier swissprot:YJBT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJBT_ECOLI helixturnhelix swissprot:YJBT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJBT_ECOLI hmoment swissprot:YJBT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJBT_ECOLI iep swissprot:YJBT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJBT_ECOLI inforesidue swissprot:YJBT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJBT_ECOLI octanol swissprot:YJBT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJBT_ECOLI pepcoil swissprot:YJBT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJBT_ECOLI pepdigest swissprot:YJBT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJBT_ECOLI pepinfo swissprot:YJBT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJBT_ECOLI pepnet swissprot:YJBT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJBT_ECOLI pepstats swissprot:YJBT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJBT_ECOLI pepwheel swissprot:YJBT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJBT_ECOLI pepwindow swissprot:YJBT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJBT_ECOLI sigcleave swissprot:YJBT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJBT_ECOLI ## Database ID URL or Descriptions # BioGrid 4262747 4 # EcoGene EG11974 fimI # GO_component GO:0009289 pilus; IEA:UniProtKB-SubCell. # GO_process GO:0007155 cell adhesion; IEA:InterPro. # GO_process GO:0009297 pilus assembly; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0007155 cell adhesion # GOslim_process GO:0022607 cellular component assembly # Gene3D 2.60.40.1090 -; 1. # InterPro IPR000259 Adhesion_dom_fimbrial # InterPro IPR008966 Adhesion_dom # KEGG_Brite ko02035 Bacterial motility proteins # Organism FIMI_ECOLI Escherichia coli (strain K12) # PATRIC 32124226 VBIEscCol129921_4456 # Pfam PF00419 Fimbrial # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FIMI_ECOLI Fimbrin-like protein FimI # RefSeq NP_418735 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA97211.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=X00981; Type=Frameshift; Positions=69, 74; Evidence={ECO 0000305}; # SIMILARITY Belongs to the fimbrial protein family. {ECO 0000305}. # SUBCELLULAR LOCATION FIMI_ECOLI Fimbrium {ECO 0000305}. # SUPFAM SSF49401 SSF49401 # eggNOG COG3539 LUCA # eggNOG ENOG4108S54 Bacteria BLAST swissprot:FIMI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FIMI_ECOLI BioCyc ECOL316407:JW5779-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5779-MONOMER BioCyc EcoCyc:EG11974-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11974-MONOMER COG COG3539 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3539 DIP DIP-9617N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9617N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1111/j.1432-1033.1984.tb08386.x http://dx.doi.org/10.1111/j.1432-1033.1984.tb08386.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X00981 http://www.ebi.ac.uk/ena/data/view/X00981 EchoBASE EB1917 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1917 EcoGene EG11974 http://www.ecogene.org/geneInfo.php?eg_id=EG11974 EnsemblBacteria AAC77271 http://www.ensemblgenomes.org/id/AAC77271 EnsemblBacteria AAC77271 http://www.ensemblgenomes.org/id/AAC77271 EnsemblBacteria BAE78308 http://www.ensemblgenomes.org/id/BAE78308 EnsemblBacteria BAE78308 http://www.ensemblgenomes.org/id/BAE78308 EnsemblBacteria BAE78308 http://www.ensemblgenomes.org/id/BAE78308 EnsemblBacteria b4315 http://www.ensemblgenomes.org/id/b4315 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009289 GO_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GO_process GO:0009297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009297 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 Gene3D 2.60.40.1090 http://www.cathdb.info/version/latest/superfamily/2.60.40.1090 GeneID 948841 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948841 HOGENOM HOG000260127 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260127&db=HOGENOM6 InParanoid P39264 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39264 IntAct P39264 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39264* InterPro IPR000259 http://www.ebi.ac.uk/interpro/entry/IPR000259 InterPro IPR008966 http://www.ebi.ac.uk/interpro/entry/IPR008966 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW5779 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5779 KEGG_Gene eco:b4315 http://www.genome.jp/dbget-bin/www_bget?eco:b4315 KEGG_Orthology KO:K07351 http://www.genome.jp/dbget-bin/www_bget?KO:K07351 MINT MINT-1256126 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1256126 OMA EAGDRQM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EAGDRQM PSORT swissprot:FIMI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FIMI_ECOLI PSORT-B swissprot:FIMI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FIMI_ECOLI PSORT2 swissprot:FIMI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FIMI_ECOLI Pfam PF00419 http://pfam.xfam.org/family/PF00419 Phobius swissprot:FIMI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FIMI_ECOLI PhylomeDB P39264 http://phylomedb.org/?seqid=P39264 ProteinModelPortal P39264 http://www.proteinmodelportal.org/query/uniprot/P39264 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6147250 http://www.ncbi.nlm.nih.gov/pubmed/6147250 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418735 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418735 SMR P39264 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39264 STRING 511145.b4315 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4315&targetmode=cogs STRING COG3539 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3539&targetmode=cogs SUPFAM SSF49401 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49401 UniProtKB FIMI_ECOLI http://www.uniprot.org/uniprot/FIMI_ECOLI UniProtKB-AC P39264 http://www.uniprot.org/uniprot/P39264 charge swissprot:FIMI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FIMI_ECOLI eggNOG COG3539 http://eggnogapi.embl.de/nog_data/html/tree/COG3539 eggNOG ENOG4108S54 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108S54 epestfind swissprot:FIMI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FIMI_ECOLI garnier swissprot:FIMI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FIMI_ECOLI helixturnhelix swissprot:FIMI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FIMI_ECOLI hmoment swissprot:FIMI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FIMI_ECOLI iep swissprot:FIMI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FIMI_ECOLI inforesidue swissprot:FIMI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FIMI_ECOLI octanol swissprot:FIMI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FIMI_ECOLI pepcoil swissprot:FIMI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FIMI_ECOLI pepdigest swissprot:FIMI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FIMI_ECOLI pepinfo swissprot:FIMI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FIMI_ECOLI pepnet swissprot:FIMI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FIMI_ECOLI pepstats swissprot:FIMI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FIMI_ECOLI pepwheel swissprot:FIMI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FIMI_ECOLI pepwindow swissprot:FIMI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FIMI_ECOLI sigcleave swissprot:FIMI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FIMI_ECOLI ## Database ID URL or Descriptions # BioGrid 4261456 252 # EcoGene EG11924 yjbF # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0045203 integral component of cell outer membrane; ISM:EcoliWiki. # GO_process GO:0045226 extracellular polysaccharide biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 2.40.360.10 -; 1. # InterPro IPR021308 GfcB # InterPro IPR023373 YmcC_dom # Organism YJBF_ECOLI Escherichia coli (strain K12) # PATRIC 32123583 VBIEscCol129921_4140 # PIR B65210 B65210 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF11102 YjbF # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJBF_ECOLI Uncharacterized lipoprotein YjbF # RefSeq NP_418451 NC_000913.3 # RefSeq WP_001295278 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAC43121.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY To E.coli YmcC. {ECO 0000305}. # SUBCELLULAR LOCATION YJBF_ECOLI Cell membrane {ECO 0000255|PROSITE- ProRule PRU00303}; Lipid-anchor {ECO 0000255|PROSITE- ProRule PRU00303}. # SUPFAM SSF159270 SSF159270 # eggNOG ENOG4108MDC Bacteria # eggNOG ENOG410XP91 LUCA BLAST swissprot:YJBF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJBF_ECOLI BioCyc ECOL316407:JW5711-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5711-MONOMER BioCyc EcoCyc:EG11924-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11924-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1868 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1868 EcoGene EG11924 http://www.ecogene.org/geneInfo.php?eg_id=EG11924 EnsemblBacteria AAC76997 http://www.ensemblgenomes.org/id/AAC76997 EnsemblBacteria AAC76997 http://www.ensemblgenomes.org/id/AAC76997 EnsemblBacteria BAE78029 http://www.ensemblgenomes.org/id/BAE78029 EnsemblBacteria BAE78029 http://www.ensemblgenomes.org/id/BAE78029 EnsemblBacteria BAE78029 http://www.ensemblgenomes.org/id/BAE78029 EnsemblBacteria b4027 http://www.ensemblgenomes.org/id/b4027 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0045203 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045203 GO_process GO:0045226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045226 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 2.40.360.10 http://www.cathdb.info/version/latest/superfamily/2.40.360.10 GeneID 948533 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948533 HOGENOM HOG000280367 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000280367&db=HOGENOM6 InterPro IPR021308 http://www.ebi.ac.uk/interpro/entry/IPR021308 InterPro IPR023373 http://www.ebi.ac.uk/interpro/entry/IPR023373 KEGG_Gene ecj:JW5711 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5711 KEGG_Gene eco:b4027 http://www.genome.jp/dbget-bin/www_bget?eco:b4027 OMA TMGWTEH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TMGWTEH PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YJBF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJBF_ECOLI PSORT-B swissprot:YJBF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJBF_ECOLI PSORT2 swissprot:YJBF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJBF_ECOLI Pfam PF11102 http://pfam.xfam.org/family/PF11102 Phobius swissprot:YJBF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJBF_ECOLI ProteinModelPortal P32687 http://www.proteinmodelportal.org/query/uniprot/P32687 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418451 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418451 RefSeq WP_001295278 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295278 SMR P32687 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32687 STRING 511145.b4027 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4027&targetmode=cogs SUPFAM SSF159270 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF159270 UniProtKB YJBF_ECOLI http://www.uniprot.org/uniprot/YJBF_ECOLI UniProtKB-AC P32687 http://www.uniprot.org/uniprot/P32687 charge swissprot:YJBF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJBF_ECOLI eggNOG ENOG4108MDC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MDC eggNOG ENOG410XP91 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XP91 epestfind swissprot:YJBF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJBF_ECOLI garnier swissprot:YJBF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJBF_ECOLI helixturnhelix swissprot:YJBF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJBF_ECOLI hmoment swissprot:YJBF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJBF_ECOLI iep swissprot:YJBF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJBF_ECOLI inforesidue swissprot:YJBF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJBF_ECOLI octanol swissprot:YJBF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJBF_ECOLI pepcoil swissprot:YJBF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJBF_ECOLI pepdigest swissprot:YJBF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJBF_ECOLI pepinfo swissprot:YJBF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJBF_ECOLI pepnet swissprot:YJBF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJBF_ECOLI pepstats swissprot:YJBF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJBF_ECOLI pepwheel swissprot:YJBF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJBF_ECOLI pepwindow swissprot:YJBF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJBF_ECOLI sigcleave swissprot:YJBF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJBF_ECOLI ## Database ID URL or Descriptions # AltName MUKB_ECOLI Structural maintenance of chromosome-related protein # BioGrid 4261687 376 # DOMAIN MUKB_ECOLI The hinge domain, which separates the large intramolecular coiled coil regions, allows the homodimerization, forming a V- shaped homodimer. The N- and C-terminus together form the head domain. # EcoGene EG10618 mukB # FUNCTION MUKB_ECOLI Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organizes and compacts chromosomes. May achieve or facilitate chromosome segregation by condensation of DNA from both sides of a centrally located replisome during cell division. Stimulates both DNA relaxation and to a lesser extent decatenation activity of topoisomerase IV. {ECO 0000269|PubMed 10660686}. # GO_component GO:0000796 condensin complex; IDA:EcoCyc. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0009295 nucleoid; IEA:UniProtKB-SubCell. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IDA:EcoCyc. # GO_function GO:0005525 GTP binding; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0006260 DNA replication; IEA:UniProtKB-HAMAP. # GO_process GO:0007059 chromosome segregation; IMP:EcoliWiki. # GO_process GO:0007062 sister chromatid cohesion; IMP:EcoliWiki. # GO_process GO:0030261 chromosome condensation; IDA:EcoCyc. # GO_process GO:0051301 cell division; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0007059 chromosome segregation # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0051276 chromosome organization # GOslim_process GO:0051301 cell division # HAMAP MF_01800 MukB # INTERACTION MUKB_ECOLI P0AFI2 parC; NbExp=7; IntAct=EBI-542943, EBI-878544; # IntAct P22523 56 # InterPro IPR007406 MukB_N_dom # InterPro IPR012090 MukB # InterPro IPR027417 P-loop_NTPase # InterPro IPR032520 MukB_hinge # KEGG_Brite ko03036 Chromosome # Organism MUKB_ECOLI Escherichia coli (strain K12) # PATRIC 32117061 VBIEscCol129921_0955 # PDB 1QHL X-ray; 2.20 A; A=1-227 # PDB 2WMM X-ray; 2.30 A; A/B=645-804 # PDB 3IBP X-ray; 3.10 A; A=566-863 # PDB 4MN4 X-ray; 2.30 A; C/D=645-804 # PIR C64832 C64832 # PIR JH0228 JH0228 # PIRSF PIRSF005246 MukB # Pfam PF04310 MukB # Pfam PF16330 MukB_hinge # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MUKB_ECOLI Chromosome partition protein MukB # RefSeq NP_415444 NC_000913.3 # RefSeq WP_000572698 NZ_LN832404.1 # SIMILARITY Belongs to the SMC family. MukB subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION MUKB_ECOLI Cytoplasm, nucleoid {ECO 0000269|PubMed 11886550, ECO 0000269|PubMed 22380631}. Note=Restricted to the nucleoid region, far from the cell poles. # SUBUNIT MUKB_ECOLI Homodimerization via its hinge domain. Binds to DNA via its C-terminal region. Interacts, and probably forms a ternary complex, with MukE and MukF via its C-terminal region. The complex formation is stimulated by calcium or magnesium. Interacts with tubulin-related protein FtsZ. Identified in a complex with SpoT; IscS and ACP. Interacts with the ParC subunit of topoisomerase IV. {ECO 0000269|PubMed 10545099, ECO 0000269|PubMed 12885413, ECO 0000269|PubMed 1464330, ECO 0000269|PubMed 20921377, ECO 0000269|PubMed 9688555}. # SUPFAM SSF52540 SSF52540; 3 # eggNOG COG3096 LUCA # eggNOG ENOG4105DUC Bacteria BLAST swissprot:MUKB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MUKB_ECOLI BioCyc ECOL316407:JW0907-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0907-MONOMER BioCyc EcoCyc:EG10618-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10618-MONOMER COG COG3096 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3096 DIP DIP-10273N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10273N DOI 10.1016/S0014-5793(03)00746-4 http://dx.doi.org/10.1016/S0014-5793(03)00746-4 DOI 10.1016/S0014-5793(98)00677-2 http://dx.doi.org/10.1016/S0014-5793(98)00677-2 DOI 10.1016/S0969-2126(00)80052-0 http://dx.doi.org/10.1016/S0969-2126(00)80052-0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2001.02691.x http://dx.doi.org/10.1046/j.1365-2958.2001.02691.x DOI 10.1073/pnas.030528397 http://dx.doi.org/10.1073/pnas.030528397 DOI 10.1073/pnas.1008678107 http://dx.doi.org/10.1073/pnas.1008678107 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/emboj/18.21.5873 http://dx.doi.org/10.1093/emboj/18.21.5873 DOI 10.1111/j.1365-2958.2012.08021.x http://dx.doi.org/10.1111/j.1365-2958.2012.08021.x DOI 10.1111/j.1574-6968.1994.tb07196.x http://dx.doi.org/10.1111/j.1574-6968.1994.tb07196.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D26440 http://www.ebi.ac.uk/ena/data/view/D26440 EMBL D31701 http://www.ebi.ac.uk/ena/data/view/D31701 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X57550 http://www.ebi.ac.uk/ena/data/view/X57550 EchoBASE EB0613 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0613 EcoGene EG10618 http://www.ecogene.org/geneInfo.php?eg_id=EG10618 EnsemblBacteria AAC74010 http://www.ensemblgenomes.org/id/AAC74010 EnsemblBacteria AAC74010 http://www.ensemblgenomes.org/id/AAC74010 EnsemblBacteria BAA35670 http://www.ensemblgenomes.org/id/BAA35670 EnsemblBacteria BAA35670 http://www.ensemblgenomes.org/id/BAA35670 EnsemblBacteria BAA35670 http://www.ensemblgenomes.org/id/BAA35670 EnsemblBacteria b0924 http://www.ensemblgenomes.org/id/b0924 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0000796 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000796 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0009295 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009295 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0006260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260 GO_process GO:0007059 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007059 GO_process GO:0007062 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007062 GO_process GO:0030261 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030261 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0007059 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007059 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0051276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051276 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GeneID 945549 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945549 HAMAP MF_01800 http://hamap.expasy.org/unirule/MF_01800 HOGENOM HOG000278243 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278243&db=HOGENOM6 InParanoid P22523 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P22523 IntAct P22523 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P22523* InterPro IPR007406 http://www.ebi.ac.uk/interpro/entry/IPR007406 InterPro IPR012090 http://www.ebi.ac.uk/interpro/entry/IPR012090 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR032520 http://www.ebi.ac.uk/interpro/entry/IPR032520 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene ecj:JW0907 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0907 KEGG_Gene eco:b0924 http://www.genome.jp/dbget-bin/www_bget?eco:b0924 KEGG_Orthology KO:K03632 http://www.genome.jp/dbget-bin/www_bget?KO:K03632 MINT MINT-1225884 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1225884 OMA DRCEEIR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DRCEEIR PDB 1QHL http://www.ebi.ac.uk/pdbe-srv/view/entry/1QHL PDB 2WMM http://www.ebi.ac.uk/pdbe-srv/view/entry/2WMM PDB 3IBP http://www.ebi.ac.uk/pdbe-srv/view/entry/3IBP PDB 4MN4 http://www.ebi.ac.uk/pdbe-srv/view/entry/4MN4 PDBsum 1QHL http://www.ebi.ac.uk/pdbsum/1QHL PDBsum 2WMM http://www.ebi.ac.uk/pdbsum/2WMM PDBsum 3IBP http://www.ebi.ac.uk/pdbsum/3IBP PDBsum 4MN4 http://www.ebi.ac.uk/pdbsum/4MN4 PSORT swissprot:MUKB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MUKB_ECOLI PSORT-B swissprot:MUKB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MUKB_ECOLI PSORT2 swissprot:MUKB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MUKB_ECOLI Pfam PF04310 http://pfam.xfam.org/family/PF04310 Pfam PF16330 http://pfam.xfam.org/family/PF16330 Phobius swissprot:MUKB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MUKB_ECOLI PhylomeDB P22523 http://phylomedb.org/?seqid=P22523 ProteinModelPortal P22523 http://www.proteinmodelportal.org/query/uniprot/P22523 PubMed 10545099 http://www.ncbi.nlm.nih.gov/pubmed/10545099 PubMed 10545328 http://www.ncbi.nlm.nih.gov/pubmed/10545328 PubMed 10660686 http://www.ncbi.nlm.nih.gov/pubmed/10660686 PubMed 11886550 http://www.ncbi.nlm.nih.gov/pubmed/11886550 PubMed 12885413 http://www.ncbi.nlm.nih.gov/pubmed/12885413 PubMed 1464330 http://www.ncbi.nlm.nih.gov/pubmed/1464330 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1989883 http://www.ncbi.nlm.nih.gov/pubmed/1989883 PubMed 20921377 http://www.ncbi.nlm.nih.gov/pubmed/20921377 PubMed 22380631 http://www.ncbi.nlm.nih.gov/pubmed/22380631 PubMed 7513784 http://www.ncbi.nlm.nih.gov/pubmed/7513784 PubMed 7988894 http://www.ncbi.nlm.nih.gov/pubmed/7988894 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9688555 http://www.ncbi.nlm.nih.gov/pubmed/9688555 RefSeq NP_415444 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415444 RefSeq WP_000572698 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000572698 SMR P22523 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P22523 STRING 511145.b0924 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0924&targetmode=cogs STRING COG3096 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3096&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB MUKB_ECOLI http://www.uniprot.org/uniprot/MUKB_ECOLI UniProtKB-AC P22523 http://www.uniprot.org/uniprot/P22523 charge swissprot:MUKB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MUKB_ECOLI eggNOG COG3096 http://eggnogapi.embl.de/nog_data/html/tree/COG3096 eggNOG ENOG4105DUC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DUC epestfind swissprot:MUKB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MUKB_ECOLI garnier swissprot:MUKB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MUKB_ECOLI helixturnhelix swissprot:MUKB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MUKB_ECOLI hmoment swissprot:MUKB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MUKB_ECOLI iep swissprot:MUKB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MUKB_ECOLI inforesidue swissprot:MUKB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MUKB_ECOLI octanol swissprot:MUKB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MUKB_ECOLI pepcoil swissprot:MUKB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MUKB_ECOLI pepdigest swissprot:MUKB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MUKB_ECOLI pepinfo swissprot:MUKB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MUKB_ECOLI pepnet swissprot:MUKB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MUKB_ECOLI pepstats swissprot:MUKB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MUKB_ECOLI pepwheel swissprot:MUKB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MUKB_ECOLI pepwindow swissprot:MUKB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MUKB_ECOLI sigcleave swissprot:MUKB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MUKB_ECOLI ## Database ID URL or Descriptions # AltName GALE_ECOLI Galactowaldenase # AltName GALE_ECOLI UDP-galactose 4-epimerase # BIOPHYSICOCHEMICAL PROPERTIES GALE_ECOLI Kinetic parameters KM=18 uM for UDP-Gal (at pH 8.5) {ECO 0000269|PubMed 14235524, ECO 0000269|PubMed 8241178, ECO 0000269|PubMed 9271498}; KM=160 uM for UDP-Gal (at pH 8.5 and 27 degrees Celsius) {ECO 0000269|PubMed 14235524, ECO 0000269|PubMed 8241178, ECO 0000269|PubMed 9271498}; KM=225 uM for UDP-Glc (at pH 8.5 and 27 degrees Celsius) {ECO 0000269|PubMed 14235524, ECO 0000269|PubMed 8241178, ECO 0000269|PubMed 9271498}; Note=Kcat is 760 sec(-1) for UDP-Glc (at pH 8.5 and 27 degrees Celsius) and 24 sec(-1) for UDP-Gal (at pH 8.5).; # BRENDA 5.1.3 2026 # BioGrid 4261900 143 # CATALYTIC ACTIVITY UDP-alpha-D-glucose = UDP-alpha-D-galactose. {ECO:0000269|PubMed 14235524}. # COFACTOR GALE_ECOLI Name=NAD(+); Xref=ChEBI CHEBI 57540; Evidence={ECO 0000269|PubMed 12019271, ECO 0000269|PubMed 8241178, ECO 0000269|PubMed 8611497, ECO 0000269|PubMed 8611559, ECO 0000269|PubMed 8652544, ECO 0000269|PubMed 8931134, ECO 0000269|PubMed 9174344, ECO 0000269|PubMed 9708982}; # ENZYME REGULATION GALE_ECOLI Inhibited by UDP-phenol and NaBH3CN. {ECO 0000269|PubMed 1579570, ECO 0000269|PubMed 9271498}. # EcoGene EG10362 galE # FUNCTION GALE_ECOLI Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD. It is only active on UDP-galactose and UDP-glucose. {ECO 0000269|PubMed 14235524}. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0003978 UDP-glucose 4-epimerase activity; IDA:EcoCyc. # GO_function GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives; IDA:EcoliWiki. # GO_function GO:0070403 NAD+ binding; IDA:EcoCyc. # GO_process GO:0005975 carbohydrate metabolic process; IMP:EcoliWiki. # GO_process GO:0006012 galactose metabolic process; IDA:EcoliWiki. # GO_process GO:0009242 colanic acid biosynthetic process; IMP:EcoCyc. # GO_process GO:0033499 galactose catabolic process via UDP-galactose; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.720 -; 1. # INDUCTION By D-galactose and D-fucose. {ECO:0000269|PubMed 14235524}. # INTERACTION GALE_ECOLI Self; NbExp=3; IntAct=EBI-909010, EBI-909010; P39409 yjjW; NbExp=2; IntAct=EBI-909010, EBI-9132384; # IntAct P09147 15 # InterPro IPR005886 GalE # InterPro IPR016040 NAD(P)-bd_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00052 Galactose metabolism # KEGG_Pathway ko00520 Amino sugar and nucleotide sugar metabolism # Organism GALE_ECOLI Escherichia coli (strain K12) # PATHWAY GALE_ECOLI Carbohydrate metabolism; galactose metabolism. # PATRIC 32116719 VBIEscCol129921_0785 # PDB 1A9Y X-ray; 1.80 A; A=1-338 # PDB 1A9Z X-ray; 1.90 A; A=1-338 # PDB 1KVQ X-ray; 2.15 A; A=1-338 # PDB 1KVR X-ray; 1.90 A; A=1-338 # PDB 1KVS X-ray; 2.15 A; A=1-338 # PDB 1KVT X-ray; 2.15 A; A=1-338 # PDB 1KVU X-ray; 1.90 A; A=1-338 # PDB 1LRJ X-ray; 1.90 A; A=1-338 # PDB 1LRK X-ray; 1.75 A; A=1-338 # PDB 1LRL X-ray; 1.80 A; A=1-338 # PDB 1NAH X-ray; 1.80 A; A=1-338 # PDB 1NAI X-ray; 2.00 A; A=1-338 # PDB 1UDA X-ray; 1.80 A; A=1-338 # PDB 1UDB X-ray; 1.65 A; A=1-338 # PDB 1UDC X-ray; 1.65 A; A=1-338 # PDB 1XEL X-ray; 1.80 A; A=1-338 # PDB 2UDP X-ray; 1.80 A; A/B=1-338 # PIR S02089 XUECUG # Pfam PF16363 GDP_Man_Dehyd # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GALE_ECOLI UDP-glucose 4-epimerase # RefSeq NP_415280 NC_000913.3 # RefSeq WP_001265438 NZ_LN832404.1 # SIMILARITY Belongs to the NAD(P)-dependent epimerase/dehydratase family. {ECO 0000305}. # SUBUNIT GALE_ECOLI Homodimer. {ECO 0000269|PubMed 12019271, ECO 0000269|PubMed 1579570, ECO 0000269|PubMed 4305667, ECO 0000269|PubMed 8611497, ECO 0000269|PubMed 8611559, ECO 0000269|PubMed 8652544, ECO 0000269|PubMed 8931134, ECO 0000269|PubMed 9174344, ECO 0000269|PubMed 9271498, ECO 0000269|PubMed 9271499, ECO 0000269|PubMed 9708982}. # SUPFAM SSF51735 SSF51735 # TIGRFAMs TIGR01179 galE # eggNOG COG1087 LUCA # eggNOG ENOG4105CMR Bacteria BLAST swissprot:GALE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GALE_ECOLI BioCyc ECOL316407:JW0742-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0742-MONOMER BioCyc EcoCyc:UDPGLUCEPIM-MONOMER http://biocyc.org/getid?id=EcoCyc:UDPGLUCEPIM-MONOMER BioCyc MetaCyc:UDPGLUCEPIM-MONOMER http://biocyc.org/getid?id=MetaCyc:UDPGLUCEPIM-MONOMER COG COG1087 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1087 DIP DIP-9728N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9728N DOI 10.1002/pro.5560051102 http://dx.doi.org/10.1002/pro.5560051102 DOI 10.1002/prot.340120409 http://dx.doi.org/10.1002/prot.340120409 DOI 10.1016/0378-1119(83)90154-3 http://dx.doi.org/10.1016/0378-1119(83)90154-3 DOI 10.1021/bi00211a035 http://dx.doi.org/10.1021/bi00211a035 DOI 10.1021/bi952715y http://dx.doi.org/10.1021/bi952715y DOI 10.1021/bi960102v http://dx.doi.org/10.1021/bi960102v DOI 10.1021/bi9601114 http://dx.doi.org/10.1021/bi9601114 DOI 10.1021/bi970025j http://dx.doi.org/10.1021/bi970025j DOI 10.1021/bi970430a http://dx.doi.org/10.1021/bi970430a DOI 10.1021/bi9704313 http://dx.doi.org/10.1021/bi9704313 DOI 10.1021/bi9808969 http://dx.doi.org/10.1021/bi9808969 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M204413200 http://dx.doi.org/10.1074/jbc.M204413200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/14.19.7705 http://dx.doi.org/10.1093/nar/14.19.7705 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.1.3.2 http://www.genome.jp/dbget-bin/www_bget?EC:5.1.3.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01613 http://www.ebi.ac.uk/ena/data/view/J01613 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U07867 http://www.ebi.ac.uk/ena/data/view/U07867 EMBL X06226 http://www.ebi.ac.uk/ena/data/view/X06226 EMBL X51449 http://www.ebi.ac.uk/ena/data/view/X51449 ENZYME 5.1.3.2 http://enzyme.expasy.org/EC/5.1.3.2 EchoBASE EB0357 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0357 EcoGene EG10362 http://www.ecogene.org/geneInfo.php?eg_id=EG10362 EnsemblBacteria AAC73846 http://www.ensemblgenomes.org/id/AAC73846 EnsemblBacteria AAC73846 http://www.ensemblgenomes.org/id/AAC73846 EnsemblBacteria BAA35421 http://www.ensemblgenomes.org/id/BAA35421 EnsemblBacteria BAA35421 http://www.ensemblgenomes.org/id/BAA35421 EnsemblBacteria BAA35421 http://www.ensemblgenomes.org/id/BAA35421 EnsemblBacteria b0759 http://www.ensemblgenomes.org/id/b0759 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003978 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003978 GO_function GO:0016857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016857 GO_function GO:0070403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070403 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GO_process GO:0006012 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006012 GO_process GO:0009242 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009242 GO_process GO:0033499 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033499 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 945354 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945354 HOGENOM HOG000168001 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000168001&db=HOGENOM6 InParanoid P09147 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P09147 IntAct P09147 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P09147* IntEnz 5.1.3.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.1.3.2 InterPro IPR005886 http://www.ebi.ac.uk/interpro/entry/IPR005886 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0742 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0742 KEGG_Gene eco:b0759 http://www.genome.jp/dbget-bin/www_bget?eco:b0759 KEGG_Orthology KO:K01784 http://www.genome.jp/dbget-bin/www_bget?KO:K01784 KEGG_Pathway ko00052 http://www.genome.jp/kegg-bin/show_pathway?ko00052 KEGG_Pathway ko00520 http://www.genome.jp/kegg-bin/show_pathway?ko00520 KEGG_Reaction rn:R00291 http://www.genome.jp/dbget-bin/www_bget?rn:R00291 KEGG_Reaction rn:R02984 http://www.genome.jp/dbget-bin/www_bget?rn:R02984 OMA CGCKVYN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CGCKVYN PDB 1A9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/1A9Y PDB 1A9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/1A9Z PDB 1KVQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1KVQ PDB 1KVR http://www.ebi.ac.uk/pdbe-srv/view/entry/1KVR PDB 1KVS http://www.ebi.ac.uk/pdbe-srv/view/entry/1KVS PDB 1KVT http://www.ebi.ac.uk/pdbe-srv/view/entry/1KVT PDB 1KVU http://www.ebi.ac.uk/pdbe-srv/view/entry/1KVU PDB 1LRJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1LRJ PDB 1LRK http://www.ebi.ac.uk/pdbe-srv/view/entry/1LRK PDB 1LRL http://www.ebi.ac.uk/pdbe-srv/view/entry/1LRL PDB 1NAH http://www.ebi.ac.uk/pdbe-srv/view/entry/1NAH PDB 1NAI http://www.ebi.ac.uk/pdbe-srv/view/entry/1NAI PDB 1UDA http://www.ebi.ac.uk/pdbe-srv/view/entry/1UDA PDB 1UDB http://www.ebi.ac.uk/pdbe-srv/view/entry/1UDB PDB 1UDC http://www.ebi.ac.uk/pdbe-srv/view/entry/1UDC PDB 1XEL http://www.ebi.ac.uk/pdbe-srv/view/entry/1XEL PDB 2UDP http://www.ebi.ac.uk/pdbe-srv/view/entry/2UDP PDBsum 1A9Y http://www.ebi.ac.uk/pdbsum/1A9Y PDBsum 1A9Z http://www.ebi.ac.uk/pdbsum/1A9Z PDBsum 1KVQ http://www.ebi.ac.uk/pdbsum/1KVQ PDBsum 1KVR http://www.ebi.ac.uk/pdbsum/1KVR PDBsum 1KVS http://www.ebi.ac.uk/pdbsum/1KVS PDBsum 1KVT http://www.ebi.ac.uk/pdbsum/1KVT PDBsum 1KVU http://www.ebi.ac.uk/pdbsum/1KVU PDBsum 1LRJ http://www.ebi.ac.uk/pdbsum/1LRJ PDBsum 1LRK http://www.ebi.ac.uk/pdbsum/1LRK PDBsum 1LRL http://www.ebi.ac.uk/pdbsum/1LRL PDBsum 1NAH http://www.ebi.ac.uk/pdbsum/1NAH PDBsum 1NAI http://www.ebi.ac.uk/pdbsum/1NAI PDBsum 1UDA http://www.ebi.ac.uk/pdbsum/1UDA PDBsum 1UDB http://www.ebi.ac.uk/pdbsum/1UDB PDBsum 1UDC http://www.ebi.ac.uk/pdbsum/1UDC PDBsum 1XEL http://www.ebi.ac.uk/pdbsum/1XEL PDBsum 2UDP http://www.ebi.ac.uk/pdbsum/2UDP PSORT swissprot:GALE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GALE_ECOLI PSORT-B swissprot:GALE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GALE_ECOLI PSORT2 swissprot:GALE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GALE_ECOLI Pfam PF16363 http://pfam.xfam.org/family/PF16363 Phobius swissprot:GALE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GALE_ECOLI PhylomeDB P09147 http://phylomedb.org/?seqid=P09147 ProteinModelPortal P09147 http://www.proteinmodelportal.org/query/uniprot/P09147 PubMed 12019271 http://www.ncbi.nlm.nih.gov/pubmed/12019271 PubMed 14235524 http://www.ncbi.nlm.nih.gov/pubmed/14235524 PubMed 1579570 http://www.ncbi.nlm.nih.gov/pubmed/1579570 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2134186 http://www.ncbi.nlm.nih.gov/pubmed/2134186 PubMed 3022232 http://www.ncbi.nlm.nih.gov/pubmed/3022232 PubMed 4305667 http://www.ncbi.nlm.nih.gov/pubmed/4305667 PubMed 6301942 http://www.ncbi.nlm.nih.gov/pubmed/6301942 PubMed 8241178 http://www.ncbi.nlm.nih.gov/pubmed/8241178 PubMed 8564363 http://www.ncbi.nlm.nih.gov/pubmed/8564363 PubMed 8611497 http://www.ncbi.nlm.nih.gov/pubmed/8611497 PubMed 8611559 http://www.ncbi.nlm.nih.gov/pubmed/8611559 PubMed 8652544 http://www.ncbi.nlm.nih.gov/pubmed/8652544 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 8931134 http://www.ncbi.nlm.nih.gov/pubmed/8931134 PubMed 9174344 http://www.ncbi.nlm.nih.gov/pubmed/9174344 PubMed 9271498 http://www.ncbi.nlm.nih.gov/pubmed/9271498 PubMed 9271499 http://www.ncbi.nlm.nih.gov/pubmed/9271499 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9708982 http://www.ncbi.nlm.nih.gov/pubmed/9708982 RefSeq NP_415280 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415280 RefSeq WP_001265438 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001265438 SMR P09147 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P09147 STRING 511145.b0759 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0759&targetmode=cogs STRING COG1087 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1087&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 SWISS-2DPAGE P09147 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P09147 TIGRFAMs TIGR01179 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01179 UniProtKB GALE_ECOLI http://www.uniprot.org/uniprot/GALE_ECOLI UniProtKB-AC P09147 http://www.uniprot.org/uniprot/P09147 charge swissprot:GALE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GALE_ECOLI eggNOG COG1087 http://eggnogapi.embl.de/nog_data/html/tree/COG1087 eggNOG ENOG4105CMR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CMR epestfind swissprot:GALE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GALE_ECOLI garnier swissprot:GALE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GALE_ECOLI helixturnhelix swissprot:GALE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GALE_ECOLI hmoment swissprot:GALE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GALE_ECOLI iep swissprot:GALE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GALE_ECOLI inforesidue swissprot:GALE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GALE_ECOLI octanol swissprot:GALE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GALE_ECOLI pepcoil swissprot:GALE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GALE_ECOLI pepdigest swissprot:GALE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GALE_ECOLI pepinfo swissprot:GALE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GALE_ECOLI pepnet swissprot:GALE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GALE_ECOLI pepstats swissprot:GALE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GALE_ECOLI pepwheel swissprot:GALE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GALE_ECOLI pepwindow swissprot:GALE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GALE_ECOLI sigcleave swissprot:GALE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GALE_ECOLI ## Database ID URL or Descriptions # BioGrid 4261557 5 # EcoGene EG14386 yaaY # GO_process GO:0006974 cellular response to DNA damage stimulus; IMP:EcoCyc. # GOslim_process GO:0006950 response to stress # InterPro IPR020105 Uncharacterised_YaaY # Organism YAAY_ECOLI Escherichia coli (strain K12) # PATRIC 32115139 VBIEscCol129921_0021 # PIR H64722 H64722 # Pfam PF10837 DUF2575 # ProDom PD056390 Uncharacterised_YaaY # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAAY_ECOLI Uncharacterized protein YaaY # RefSeq NP_414565 NC_000913.3 # RefSeq WP_001300728 NZ_LN832404.1 # eggNOG ENOG410647N Bacteria # eggNOG ENOG4112D6N LUCA BLAST swissprot:YAAY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAAY_ECOLI BioCyc ECOL316407:JW5003-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5003-MONOMER BioCyc EcoCyc:G6087-MONOMER http://biocyc.org/getid?id=EcoCyc:G6087-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4129 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4129 EcoGene EG14386 http://www.ecogene.org/geneInfo.php?eg_id=EG14386 EnsemblBacteria AAC73135 http://www.ensemblgenomes.org/id/AAC73135 EnsemblBacteria AAC73135 http://www.ensemblgenomes.org/id/AAC73135 EnsemblBacteria BAE76035 http://www.ensemblgenomes.org/id/BAE76035 EnsemblBacteria BAE76035 http://www.ensemblgenomes.org/id/BAE76035 EnsemblBacteria BAE76035 http://www.ensemblgenomes.org/id/BAE76035 EnsemblBacteria b0024 http://www.ensemblgenomes.org/id/b0024 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 949128 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949128 HOGENOM HOG000009320 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009320&db=HOGENOM6 InterPro IPR020105 http://www.ebi.ac.uk/interpro/entry/IPR020105 KEGG_Gene ecj:JW5003 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5003 KEGG_Gene eco:b0024 http://www.genome.jp/dbget-bin/www_bget?eco:b0024 OMA CICLIAM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CICLIAM PSORT swissprot:YAAY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAAY_ECOLI PSORT-B swissprot:YAAY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAAY_ECOLI PSORT2 swissprot:YAAY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAAY_ECOLI Pfam PF10837 http://pfam.xfam.org/family/PF10837 Phobius swissprot:YAAY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAAY_ECOLI ProteinModelPortal P75620 http://www.proteinmodelportal.org/query/uniprot/P75620 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414565 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414565 RefSeq WP_001300728 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300728 STRING 511145.b0024 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0024&targetmode=cogs UniProtKB YAAY_ECOLI http://www.uniprot.org/uniprot/YAAY_ECOLI UniProtKB-AC P75620 http://www.uniprot.org/uniprot/P75620 charge swissprot:YAAY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAAY_ECOLI eggNOG ENOG410647N http://eggnogapi.embl.de/nog_data/html/tree/ENOG410647N eggNOG ENOG4112D6N http://eggnogapi.embl.de/nog_data/html/tree/ENOG4112D6N epestfind swissprot:YAAY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAAY_ECOLI garnier swissprot:YAAY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAAY_ECOLI helixturnhelix swissprot:YAAY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAAY_ECOLI hmoment swissprot:YAAY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAAY_ECOLI iep swissprot:YAAY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAAY_ECOLI inforesidue swissprot:YAAY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAAY_ECOLI octanol swissprot:YAAY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAAY_ECOLI pepcoil swissprot:YAAY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAAY_ECOLI pepdigest swissprot:YAAY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAAY_ECOLI pepinfo swissprot:YAAY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAAY_ECOLI pepnet swissprot:YAAY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAAY_ECOLI pepstats swissprot:YAAY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAAY_ECOLI pepwheel swissprot:YAAY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAAY_ECOLI pepwindow swissprot:YAAY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAAY_ECOLI sigcleave swissprot:YAAY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAAY_ECOLI ## Database ID URL or Descriptions # AltName CCA_ECOLI CCA tRNA nucleotidyltransferase # AltName CCA_ECOLI tRNA CCA-pyrophosphorylase # AltName CCA_ECOLI tRNA adenylyl-/cytidylyl-transferase # AltName CCA_ECOLI tRNA nucleotidyltransferase # AltName CCA_ECOLI tRNA-NT # AltName CCA_ECOLI tRNA-NT # BIOPHYSICOCHEMICAL PROPERTIES CCA_ECOLI Kinetic parameters KM=0.33 mM for ATP (in the tRNA-NT activity assay) {ECO 0000269|PubMed 15210699, ECO 0000269|PubMed 3516995}; KM=0.03 mM for CTP (in the tRNA-NT activity assay) {ECO 0000269|PubMed 15210699, ECO 0000269|PubMed 3516995}; KM=0.015 mM for tRNA-CC {ECO 0000269|PubMed 15210699, ECO 0000269|PubMed 3516995}; KM=0.02 mM for tRNA-C {ECO 0000269|PubMed 15210699, ECO 0000269|PubMed 3516995}; KM=6.2 mM for pNPP {ECO 0000269|PubMed 15210699, ECO 0000269|PubMed 3516995}; KM=0.10 mM for PPi {ECO 0000269|PubMed 15210699, ECO 0000269|PubMed 3516995}; KM=0.15 mM for NADP {ECO 0000269|PubMed 15210699, ECO 0000269|PubMed 3516995}; KM=0.19 mM for ADP {ECO 0000269|PubMed 15210699, ECO 0000269|PubMed 3516995}; KM=0.18 mM for ATP (in the phosphatase activity assay) {ECO 0000269|PubMed 15210699, ECO 0000269|PubMed 3516995}; KM=0.53 mM for CDP {ECO 0000269|PubMed 15210699, ECO 0000269|PubMed 3516995}; KM=0.13 mM for CTP (in the phosphatase activity assay) {ECO 0000269|PubMed 15210699, ECO 0000269|PubMed 3516995}; KM=0.76 mM for 2'-AMP {ECO 0000269|PubMed 15210699, ECO 0000269|PubMed 3516995}; KM=0.49 mM for 2',3'-cAMP {ECO 0000269|PubMed 15210699, ECO 0000269|PubMed 3516995}; KM=1.60 mM for 2',3'-cGMP {ECO 0000269|PubMed 15210699, ECO 0000269|PubMed 3516995}; Vmax=12.4 umol/min/mg enzyme with pNPP as substrate {ECO 0000269|PubMed 15210699, ECO 0000269|PubMed 3516995}; Vmax=3.01 umol/min/mg enzyme with PPi as substrate {ECO 0000269|PubMed 15210699, ECO 0000269|PubMed 3516995}; Vmax=17.9 umol/min/mg enzyme with NADP as substrate {ECO 0000269|PubMed 15210699, ECO 0000269|PubMed 3516995}; Vmax=1.49 umol/min/mg enzyme with ADP as substrate {ECO 0000269|PubMed 15210699, ECO 0000269|PubMed 3516995}; Vmax=4.53 umol/min/mg enzyme with ATP as substrate (in the phosphatase activity assay) {ECO 0000269|PubMed 15210699, ECO 0000269|PubMed 3516995}; Vmax=5.80 umol/min/mg enzyme with CDP as substrate {ECO 0000269|PubMed 15210699, ECO 0000269|PubMed 3516995}; Vmax=4.03 umol/min/mg enzyme with CTP as substrate (in the phosphatase activity assay) {ECO 0000269|PubMed 15210699, ECO 0000269|PubMed 3516995}; Vmax=3.71 umol/min/mg enzyme with 2'-AMP as substrate {ECO 0000269|PubMed 15210699, ECO 0000269|PubMed 3516995}; Vmax=3.21 umol/min/mg enzyme with 2',3'-cAMP as substrate {ECO 0000269|PubMed 15210699, ECO 0000269|PubMed 3516995}; Vmax=2.36 umol/min/mg enzyme with 2',3'-cGMP as substrate {ECO 0000269|PubMed 15210699, ECO 0000269|PubMed 3516995}; pH dependence Optimum pH is 9.4 for AMP incorporation, 10.0 for CMP incorporation, and 7.0 for the phosphatase and phosphodiesterase activities. {ECO 0000269|PubMed 15210699, ECO 0000269|PubMed 3516995}; # BRENDA 2.7.7.72 2026 # BRENDA 3.1.4.16 2026 # BRENDA 3.1.4.37 2026 # BioGrid 4259255 13 # CATALYTIC ACTIVITY CCA_ECOLI A tRNA precursor + 2 CTP + ATP = a tRNA with a 3' CCA end + 3 diphosphate. # CDD cd05398 NT_ClassII-CCAase # COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI 18420; Note=Magnesium is required for nucleotidyltransferase activity.; # COFACTOR Name=Ni(2+); Xref=ChEBI:CHEBI 49786; Note=Nickel for phosphatase activity.; # DOMAIN CCA_ECOLI Comprises two domains an N-terminal domain containing the nucleotidyltransferase activity and a C-terminal HD domain associated with both phosphodiesterase and phosphatase activities. # ENZYME REGULATION CCA_ECOLI Both phosphatase and phosphodiesterase activities are competitively inhibited by low concentrations of the E.coli tRNA (10 nM). Cu(2+) stimulates the hydrolysis of pyrophosphate and ATP and completely inhibits the hydrolysis of 2'-AMP. The phosphodiesterase activity is inhibited by Zn(2+), Cu(2+) and Co(2+). # EcoGene EG10136 cca # FUNCTION CCA_ECOLI Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows highest phosphatase activity in the presence of Ni(2+) and hydrolyzes pyrophosphate, canonical 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi. Displays a metal-independent phosphodiesterase activity toward 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP. Without metal or in the presence of Mg(2+), this protein hydrolyzes 2',3'-cyclic substrates with the formation of 2'-nucleotides, whereas in the presence of Ni(2+), it also produces some 3'-nucleotides. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases. {ECO 0000269|PubMed 3516995}. # GO_function CCA_ECOLI GO 0052927 CTP tRNA cytidylyltransferase activity; IEA UniProtKB-EC. # GO_function CCA_ECOLI GO 0052928 CTP 3'-cytidine-tRNA cytidylyltransferase activity; IEA UniProtKB-EC. # GO_function CCA_ECOLI GO 0052929 ATP 3'-cytidine-cytidine-tRNA adenylyltransferase activity; IEA UniProtKB-EC. # GO_function GO:0000049 tRNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0004112 cyclic-nucleotide phosphodiesterase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0004810 tRNA adenylyltransferase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0016437 tRNA cytidylyltransferase activity; IDA:EcoCyc. # GO_function GO:0016791 phosphatase activity; IEA:UniProtKB-HAMAP. # GO_process GO:0001680 tRNA 3'-terminal CCA addition; IDA:EcoCyc. # GO_process GO:0042245 RNA repair; IMP:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # HAMAP MF_01261 CCA_bact_type1 # HAMAP MF_01262 CCA_bact_type2 # IntAct P06961 24 # InterPro IPR002646 PolA_pol_head_dom # InterPro IPR006674 HD_domain # InterPro IPR012006 CCA_bact # InterPro IPR032828 PolyA_RNA-bd # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # KEGG_Pathway ko03013 RNA transport # MISCELLANEOUS A single active site specifically recognizes both ATP and CTP and is responsible for their addition. {ECO 0000250}. # Organism CCA_ECOLI Escherichia coli (strain K12) # PATRIC 32121524 VBIEscCol129921_3149 # PIR A25215 RNECTA # PIRSF PIRSF000813 CCA_bact # Pfam PF01743 PolyA_pol # Pfam PF01966 HD # Pfam PF12627 PolyA_pol_RNAbd # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CCA_ECOLI 2',3'-cyclic phosphodiesterase # RecName CCA_ECOLI 2'-nucleotidase # RecName CCA_ECOLI CCA-adding enzyme # RecName CCA_ECOLI Multifunctional CCA protein # RecName CCA_ECOLI Multifunctional CCA protein # RecName CCA_ECOLI Phosphatase # RefSeq NP_417528 NC_000913.3 # RefSeq WP_000708487 NZ_LN832404.1 # SIMILARITY Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 1 subfamily. {ECO 0000305}. # SUBUNIT Monomer. Can also form homodimers and oligomers, but with low levels. {ECO:0000269|PubMed 15210699}. # eggNOG COG0617 LUCA # eggNOG ENOG4105D4J Bacteria BLAST swissprot:CCA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CCA_ECOLI BioCyc ECOL316407:JW3028-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3028-MONOMER BioCyc EcoCyc:EG10136-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10136-MONOMER BioCyc MetaCyc:EG10136-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10136-MONOMER COG COG0617 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0617 DIP DIP-9250N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9250N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M405120200 http://dx.doi.org/10.1074/jbc.M405120200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.7.72 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.72 EC_number EC:3.1.3.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.- EC_number EC:3.1.3.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.- EC_number EC:3.1.4.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.4.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M12788 http://www.ebi.ac.uk/ena/data/view/M12788 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28379 http://www.ebi.ac.uk/ena/data/view/U28379 ENZYME 2.7.7.72 http://enzyme.expasy.org/EC/2.7.7.72 ENZYME 3.1.3.- http://enzyme.expasy.org/EC/3.1.3.- ENZYME 3.1.3.- http://enzyme.expasy.org/EC/3.1.3.- ENZYME 3.1.4.- http://enzyme.expasy.org/EC/3.1.4.- EchoBASE EB0134 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0134 EcoGene EG10136 http://www.ecogene.org/geneInfo.php?eg_id=EG10136 EnsemblBacteria AAC76092 http://www.ensemblgenomes.org/id/AAC76092 EnsemblBacteria AAC76092 http://www.ensemblgenomes.org/id/AAC76092 EnsemblBacteria BAE77107 http://www.ensemblgenomes.org/id/BAE77107 EnsemblBacteria BAE77107 http://www.ensemblgenomes.org/id/BAE77107 EnsemblBacteria BAE77107 http://www.ensemblgenomes.org/id/BAE77107 EnsemblBacteria b3056 http://www.ensemblgenomes.org/id/b3056 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000049 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0004112 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004112 GO_function GO:0004810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004810 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016437 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016437 GO_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GO_function GO:0052927 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052927 GO_function GO:0052928 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052928 GO_function GO:0052929 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052929 GO_process GO:0001680 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001680 GO_process GO:0042245 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042245 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 947553 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947553 HAMAP MF_01261 http://hamap.expasy.org/unirule/MF_01261 HAMAP MF_01262 http://hamap.expasy.org/unirule/MF_01262 HOGENOM HOG000007368 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000007368&db=HOGENOM6 InParanoid P06961 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P06961 IntAct P06961 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P06961* IntEnz 2.7.7.72 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.72 IntEnz 3.1.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3 IntEnz 3.1.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3 IntEnz 3.1.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.4 InterPro IPR002646 http://www.ebi.ac.uk/interpro/entry/IPR002646 InterPro IPR006674 http://www.ebi.ac.uk/interpro/entry/IPR006674 InterPro IPR012006 http://www.ebi.ac.uk/interpro/entry/IPR012006 InterPro IPR032828 http://www.ebi.ac.uk/interpro/entry/IPR032828 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW3028 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3028 KEGG_Gene eco:b3056 http://www.genome.jp/dbget-bin/www_bget?eco:b3056 KEGG_Orthology KO:K00974 http://www.genome.jp/dbget-bin/www_bget?KO:K00974 KEGG_Pathway ko03013 http://www.genome.jp/kegg-bin/show_pathway?ko03013 KEGG_Reaction rn:R09382 http://www.genome.jp/dbget-bin/www_bget?rn:R09382 KEGG_Reaction rn:R09383 http://www.genome.jp/dbget-bin/www_bget?rn:R09383 KEGG_Reaction rn:R09384 http://www.genome.jp/dbget-bin/www_bget?rn:R09384 KEGG_Reaction rn:R09386 http://www.genome.jp/dbget-bin/www_bget?rn:R09386 MINT MINT-1263446 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1263446 OMA SEWPSHK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SEWPSHK PSORT swissprot:CCA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CCA_ECOLI PSORT-B swissprot:CCA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CCA_ECOLI PSORT2 swissprot:CCA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CCA_ECOLI Pfam PF01743 http://pfam.xfam.org/family/PF01743 Pfam PF01966 http://pfam.xfam.org/family/PF01966 Pfam PF12627 http://pfam.xfam.org/family/PF12627 Phobius swissprot:CCA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CCA_ECOLI PhylomeDB P06961 http://phylomedb.org/?seqid=P06961 ProteinModelPortal P06961 http://www.proteinmodelportal.org/query/uniprot/P06961 PubMed 15210699 http://www.ncbi.nlm.nih.gov/pubmed/15210699 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3009457 http://www.ncbi.nlm.nih.gov/pubmed/3009457 PubMed 3516995 http://www.ncbi.nlm.nih.gov/pubmed/3516995 PubMed 3533927 http://www.ncbi.nlm.nih.gov/pubmed/3533927 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417528 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417528 RefSeq WP_000708487 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000708487 STRING 511145.b3056 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3056&targetmode=cogs STRING COG0617 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0617&targetmode=cogs UniProtKB CCA_ECOLI http://www.uniprot.org/uniprot/CCA_ECOLI UniProtKB-AC P06961 http://www.uniprot.org/uniprot/P06961 charge swissprot:CCA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CCA_ECOLI eggNOG COG0617 http://eggnogapi.embl.de/nog_data/html/tree/COG0617 eggNOG ENOG4105D4J http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D4J epestfind swissprot:CCA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CCA_ECOLI garnier swissprot:CCA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CCA_ECOLI helixturnhelix swissprot:CCA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CCA_ECOLI hmoment swissprot:CCA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CCA_ECOLI iep swissprot:CCA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CCA_ECOLI inforesidue swissprot:CCA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CCA_ECOLI octanol swissprot:CCA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CCA_ECOLI pepcoil swissprot:CCA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CCA_ECOLI pepdigest swissprot:CCA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CCA_ECOLI pepinfo swissprot:CCA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CCA_ECOLI pepnet swissprot:CCA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CCA_ECOLI pepstats swissprot:CCA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CCA_ECOLI pepwheel swissprot:CCA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CCA_ECOLI pepwindow swissprot:CCA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CCA_ECOLI sigcleave swissprot:CCA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CCA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261178 13 # EcoGene EG13002 yghR # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.300 -; 1. # IntAct P64572 4 # InterPro IPR027417 P-loop_NTPase # Organism YGHR_ECOLI Escherichia coli (strain K12) # PATRIC 32121384 VBIEscCol129921_3079 # PIR F65084 F65084 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGHR_ECOLI Uncharacterized ATP-binding protein YghR # RefSeq NP_417458 NC_000913.3 # RefSeq WP_000339531 NZ_LN832404.1 # SIMILARITY To E.coli YghS and YghT. {ECO 0000305}. # SUPFAM SSF52540 SSF52540; 2 # eggNOG ENOG4106FPV Bacteria # eggNOG ENOG410XRBC LUCA BLAST swissprot:YGHR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGHR_ECOLI BioCyc ECOL316407:JW2952-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2952-MONOMER BioCyc EcoCyc:G7550-MONOMER http://biocyc.org/getid?id=EcoCyc:G7550-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2824 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2824 EcoGene EG13002 http://www.ecogene.org/geneInfo.php?eg_id=EG13002 EnsemblBacteria AAC76020 http://www.ensemblgenomes.org/id/AAC76020 EnsemblBacteria AAC76020 http://www.ensemblgenomes.org/id/AAC76020 EnsemblBacteria BAE77045 http://www.ensemblgenomes.org/id/BAE77045 EnsemblBacteria BAE77045 http://www.ensemblgenomes.org/id/BAE77045 EnsemblBacteria BAE77045 http://www.ensemblgenomes.org/id/BAE77045 EnsemblBacteria b2984 http://www.ensemblgenomes.org/id/b2984 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947310 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947310 HOGENOM HOG000124979 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000124979&db=HOGENOM6 IntAct P64572 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P64572* InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Gene ecj:JW2952 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2952 KEGG_Gene eco:b2984 http://www.genome.jp/dbget-bin/www_bget?eco:b2984 OMA ETAHARK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ETAHARK PSORT swissprot:YGHR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGHR_ECOLI PSORT-B swissprot:YGHR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGHR_ECOLI PSORT2 swissprot:YGHR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGHR_ECOLI Phobius swissprot:YGHR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGHR_ECOLI PhylomeDB P64572 http://phylomedb.org/?seqid=P64572 ProteinModelPortal P64572 http://www.proteinmodelportal.org/query/uniprot/P64572 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417458 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417458 RefSeq WP_000339531 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000339531 STRING 511145.b2984 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2984&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB YGHR_ECOLI http://www.uniprot.org/uniprot/YGHR_ECOLI UniProtKB-AC P64572 http://www.uniprot.org/uniprot/P64572 charge swissprot:YGHR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGHR_ECOLI eggNOG ENOG4106FPV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106FPV eggNOG ENOG410XRBC http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRBC epestfind swissprot:YGHR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGHR_ECOLI garnier swissprot:YGHR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGHR_ECOLI helixturnhelix swissprot:YGHR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGHR_ECOLI hmoment swissprot:YGHR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGHR_ECOLI iep swissprot:YGHR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGHR_ECOLI inforesidue swissprot:YGHR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGHR_ECOLI octanol swissprot:YGHR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGHR_ECOLI pepcoil swissprot:YGHR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGHR_ECOLI pepdigest swissprot:YGHR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGHR_ECOLI pepinfo swissprot:YGHR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGHR_ECOLI pepnet swissprot:YGHR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGHR_ECOLI pepstats swissprot:YGHR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGHR_ECOLI pepwheel swissprot:YGHR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGHR_ECOLI pepwindow swissprot:YGHR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGHR_ECOLI sigcleave swissprot:YGHR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGHR_ECOLI ## Database ID URL or Descriptions # BRENDA 5.3.1.24 2026 # BioGrid 4260122 4 # CATALYTIC ACTIVITY TRPC_ECOLI 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5- phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO(2) + H(2)O. # CATALYTIC ACTIVITY TRPC_ECOLI N-(5-phospho-beta-D-ribosyl)anthranilate = 1- (2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate. # CDD cd00331 IGPS # CDD cd00405 PRAI # EcoGene EG11026 trpC # FUNCTION TRPC_ECOLI Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain. # GO_function GO:0004425 indole-3-glycerol-phosphate synthase activity; IDA:EcoCyc. # GO_function GO:0004640 phosphoribosylanthranilate isomerase activity; IDA:EcoCyc. # GO_process GO:0000162 tryptophan biosynthetic process; IMP:EcoCyc. # GO_process GO:0008652 cellular amino acid biosynthetic process; IEA:UniProtKB-KW. # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.20.20.70 -; 2. # HAMAP MF_00134_B IGPS_B # HAMAP MF_00135 PRAI # IntAct P00909 7 # InterPro IPR001240 PRAI # InterPro IPR001468 Indole-3-GlycerolPSynthase_CS # InterPro IPR011060 RibuloseP-bd_barrel # InterPro IPR013785 Aldolase_TIM # InterPro IPR013798 Indole-3-glycerol_P_synth # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis # Organism TRPC_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-tryptophan biosynthesis; L- tryptophan from chorismate step 3/5. # PATHWAY Amino-acid biosynthesis; L-tryptophan biosynthesis; L- tryptophan from chorismate step 4/5. # PATRIC 32117784 VBIEscCol129921_1312 # PDB 1JCM X-ray; 2.10 A; P=2-260 # PDB 1PII X-ray; 2.00 A; A=2-453 # PDB 2KZH NMR; -; A=256-385 # PIR A64874 GWEC # PROSITE PS00614 IGPS # Pfam PF00218 IGPS # Pfam PF00697 PRAI # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TRPC_ECOLI Indole-3-glycerol phosphate synthase # RecName TRPC_ECOLI N-(5'-phospho-ribosyl)anthranilate isomerase # RecName TRPC_ECOLI Tryptophan biosynthesis protein TrpCF # RecName TRPC_ECOLI Tryptophan biosynthesis protein TrpCF # RefSeq NP_415778 NC_000913.3 # SIMILARITY In the C-terminal section; belongs to the TrpF family. {ECO 0000305}. # SIMILARITY In the N-terminal section; belongs to the TrpC family. {ECO 0000305}. # SUBUNIT TRPC_ECOLI Monomer. # SUPFAM SSF51366 SSF51366; 2 # UniPathway UPA00035 UER00042 # UniPathway UPA00035 UER00043 # eggNOG COG0134 LUCA # eggNOG COG0135 LUCA # eggNOG ENOG4105DK0 Bacteria BLAST swissprot:TRPC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRPC_ECOLI BioCyc ECOL316407:JW1254-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1254-MONOMER BioCyc EcoCyc:PRAI-IGPS http://biocyc.org/getid?id=EcoCyc:PRAI-IGPS BioCyc MetaCyc:PRAI-IGPS http://biocyc.org/getid?id=MetaCyc:PRAI-IGPS COG COG0134 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0134 COG COG0135 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0135 DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0022-2836(80)90261-2 http://dx.doi.org/10.1016/0022-2836(80)90261-2 DOI 10.1016/0022-2836(92)90665-7 http://dx.doi.org/10.1016/0022-2836(92)90665-7 DOI 10.1016/S0022-2836(83)80136-3 http://dx.doi.org/10.1016/S0022-2836(83)80136-3 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/mcp.M113.029165 http://dx.doi.org/10.1074/mcp.M113.029165 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/9.24.6647 http://dx.doi.org/10.1093/nar/9.24.6647 DOI 10.1093/protein/3.3.173 http://dx.doi.org/10.1093/protein/3.3.173 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.1.1.48 http://www.genome.jp/dbget-bin/www_bget?EC:4.1.1.48 EC_number EC:5.3.1.24 http://www.genome.jp/dbget-bin/www_bget?EC:5.3.1.24 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01714 http://www.ebi.ac.uk/ena/data/view/J01714 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U23489 http://www.ebi.ac.uk/ena/data/view/U23489 EMBL V00366 http://www.ebi.ac.uk/ena/data/view/V00366 EMBL V00372 http://www.ebi.ac.uk/ena/data/view/V00372 ENZYME 4.1.1.48 http://enzyme.expasy.org/EC/4.1.1.48 ENZYME 5.3.1.24 http://enzyme.expasy.org/EC/5.3.1.24 EchoBASE EB1019 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1019 EcoGene EG11026 http://www.ecogene.org/geneInfo.php?eg_id=EG11026 EnsemblBacteria AAC74344 http://www.ensemblgenomes.org/id/AAC74344 EnsemblBacteria AAC74344 http://www.ensemblgenomes.org/id/AAC74344 EnsemblBacteria BAA14794 http://www.ensemblgenomes.org/id/BAA14794 EnsemblBacteria BAA14794 http://www.ensemblgenomes.org/id/BAA14794 EnsemblBacteria BAA14794 http://www.ensemblgenomes.org/id/BAA14794 EnsemblBacteria b1262 http://www.ensemblgenomes.org/id/b1262 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004425 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004425 GO_function GO:0004640 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004640 GO_process GO:0000162 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000162 GO_process GO:0008652 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008652 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 945519 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945519 HAMAP MF_00134_B http://hamap.expasy.org/unirule/MF_00134_B HAMAP MF_00135 http://hamap.expasy.org/unirule/MF_00135 HOGENOM HOG000280458 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000280458&db=HOGENOM6 InParanoid P00909 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00909 IntAct P00909 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00909* IntEnz 4.1.1.48 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.1.48 IntEnz 5.3.1.24 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.3.1.24 InterPro IPR001240 http://www.ebi.ac.uk/interpro/entry/IPR001240 InterPro IPR001468 http://www.ebi.ac.uk/interpro/entry/IPR001468 InterPro IPR011060 http://www.ebi.ac.uk/interpro/entry/IPR011060 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR013798 http://www.ebi.ac.uk/interpro/entry/IPR013798 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1254 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1254 KEGG_Gene eco:b1262 http://www.genome.jp/dbget-bin/www_bget?eco:b1262 KEGG_Orthology KO:K13498 http://www.genome.jp/dbget-bin/www_bget?KO:K13498 KEGG_Pathway ko00400 http://www.genome.jp/kegg-bin/show_pathway?ko00400 KEGG_Reaction rn:R03508 http://www.genome.jp/dbget-bin/www_bget?rn:R03508 KEGG_Reaction rn:R03509 http://www.genome.jp/dbget-bin/www_bget?rn:R03509 PDB 1JCM http://www.ebi.ac.uk/pdbe-srv/view/entry/1JCM PDB 1PII http://www.ebi.ac.uk/pdbe-srv/view/entry/1PII PDB 2KZH http://www.ebi.ac.uk/pdbe-srv/view/entry/2KZH PDBsum 1JCM http://www.ebi.ac.uk/pdbsum/1JCM PDBsum 1PII http://www.ebi.ac.uk/pdbsum/1PII PDBsum 2KZH http://www.ebi.ac.uk/pdbsum/2KZH PROSITE PS00614 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00614 PSORT swissprot:TRPC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRPC_ECOLI PSORT-B swissprot:TRPC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRPC_ECOLI PSORT2 swissprot:TRPC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRPC_ECOLI Pfam PF00218 http://pfam.xfam.org/family/PF00218 Pfam PF00697 http://pfam.xfam.org/family/PF00697 Phobius swissprot:TRPC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRPC_ECOLI ProteinModelPortal P00909 http://www.proteinmodelportal.org/query/uniprot/P00909 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1738159 http://www.ncbi.nlm.nih.gov/pubmed/1738159 PubMed 2184433 http://www.ncbi.nlm.nih.gov/pubmed/2184433 PubMed 23908556 http://www.ncbi.nlm.nih.gov/pubmed/23908556 PubMed 6355484 http://www.ncbi.nlm.nih.gov/pubmed/6355484 PubMed 7007653 http://www.ncbi.nlm.nih.gov/pubmed/7007653 PubMed 7038627 http://www.ncbi.nlm.nih.gov/pubmed/7038627 PubMed 8095913 http://www.ncbi.nlm.nih.gov/pubmed/8095913 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_415778 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415778 SMR P00909 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00909 STRING 511145.b1262 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1262&targetmode=cogs STRING COG0134 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0134&targetmode=cogs STRING COG0135 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0135&targetmode=cogs SUPFAM SSF51366 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51366 UniProtKB TRPC_ECOLI http://www.uniprot.org/uniprot/TRPC_ECOLI UniProtKB-AC P00909 http://www.uniprot.org/uniprot/P00909 charge swissprot:TRPC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRPC_ECOLI eggNOG COG0134 http://eggnogapi.embl.de/nog_data/html/tree/COG0134 eggNOG COG0135 http://eggnogapi.embl.de/nog_data/html/tree/COG0135 eggNOG ENOG4105DK0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DK0 epestfind swissprot:TRPC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRPC_ECOLI garnier swissprot:TRPC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRPC_ECOLI helixturnhelix swissprot:TRPC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRPC_ECOLI hmoment swissprot:TRPC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRPC_ECOLI iep swissprot:TRPC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRPC_ECOLI inforesidue swissprot:TRPC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRPC_ECOLI octanol swissprot:TRPC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRPC_ECOLI pepcoil swissprot:TRPC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRPC_ECOLI pepdigest swissprot:TRPC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRPC_ECOLI pepinfo swissprot:TRPC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRPC_ECOLI pepnet swissprot:TRPC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRPC_ECOLI pepstats swissprot:TRPC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRPC_ECOLI pepwheel swissprot:TRPC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRPC_ECOLI pepwindow swissprot:TRPC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRPC_ECOLI sigcleave swissprot:TRPC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRPC_ECOLI ## Database ID URL or Descriptions # AltName FADA_ECOLI Acetyl-CoA acyltransferase # AltName FADA_ECOLI Beta-ketothiolase # AltName FADA_ECOLI Fatty acid oxidation complex subunit beta # BIOPHYSICOCHEMICAL PROPERTIES FADA_ECOLI Kinetic parameters KM=96 uM for acetoacetyl-CoA {ECO 0000269|PubMed 8454629}; KM=102 uM for CoASH {ECO 0000269|PubMed 8454629}; # BioGrid 4263456 162 # CATALYTIC ACTIVITY FADA_ECOLI Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA. # EcoGene EG10278 fadA # FUNCTION FADA_ECOLI Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. Involved in the aerobic and anaerobic degradation of long-chain fatty acids. {ECO 0000269|PubMed 12535077, ECO 0000269|PubMed 368024}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003988 acetyl-CoA C-acyltransferase activity; IDA:UniProtKB. # GO_process GO:0006635 fatty acid beta-oxidation; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.47.10 -; 4. # HAMAP MF_01620 FadA # INDUCTION FADA_ECOLI Repressed by FadR in the absence of LCFAs (fatty acids of, at least, 12 carbon atoms). When LCFAs are present in the medium, they are converted to long-chain acyl-CoAs which bind to FadR resulting in its release from the DNA and thus derepression of the transcription. # InterPro IPR002155 Thiolase # InterPro IPR012805 FadA # InterPro IPR016039 Thiolase-like # InterPro IPR020610 Thiolase_AS # InterPro IPR020613 Thiolase_CS # InterPro IPR020615 Thiolase_acyl_enz_int_AS # InterPro IPR020616 Thiolase_N # InterPro IPR020617 Thiolase_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00071 Fatty acid metabolism # KEGG_Pathway ko00280 Valine, leucine and isoleucine degradation # KEGG_Pathway ko00281 Geraniol degradation # KEGG_Pathway ko00362 Benzoate degradation # KEGG_Pathway ko00592 alpha-Linolenic acid metabolism # KEGG_Pathway ko00642 Ethylbenzene degradation # Organism FADA_ECOLI Escherichia coli (strain K12) # PATHWAY FADA_ECOLI Lipid metabolism; fatty acid beta-oxidation. # PATRIC 32123187 VBIEscCol129921_3959 # PIR F65189 XUEC # PIRSF PIRSF000429 Ac-CoA_Ac_transf # PROSITE PS00098 THIOLASE_1 # PROSITE PS00099 THIOLASE_3 # PROSITE PS00737 THIOLASE_2 # Pfam PF00108 Thiolase_N # Pfam PF02803 Thiolase_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FADA_ECOLI 3-ketoacyl-CoA thiolase # RefSeq WP_000438725 NZ_LN832404.1 # RefSeq YP_026272 NC_000913.3 # SIMILARITY Belongs to the thiolase family. {ECO 0000305}. # SUBCELLULAR LOCATION FADA_ECOLI Cytoplasm. # SUBUNIT Heterotetramer of two alpha chains (FadB) and two beta chains (FadA). {ECO:0000269|PubMed 368024}. # SUPFAM SSF53901 SSF53901; 2 # TIGRFAMs TIGR01930 AcCoA-C-Actrans # TIGRFAMs TIGR02445 fadA # eggNOG COG0183 LUCA # eggNOG ENOG4105CHU Bacteria BLAST swissprot:FADA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FADA_ECOLI BioCyc ECOL316407:JW5578-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5578-MONOMER BioCyc EcoCyc:FADA-MONOMER http://biocyc.org/getid?id=EcoCyc:FADA-MONOMER BioCyc MetaCyc:FADA-MONOMER http://biocyc.org/getid?id=MetaCyc:FADA-MONOMER COG COG0183 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0183 DIP DIP-9559N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9559N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2003.03341.x http://dx.doi.org/10.1046/j.1365-2958.2003.03341.x DOI 10.1093/nar/18.16.4937 http://dx.doi.org/10.1093/nar/18.16.4937 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.16 http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.16 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M59368 http://www.ebi.ac.uk/ena/data/view/M59368 EMBL M74164 http://www.ebi.ac.uk/ena/data/view/M74164 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X52837 http://www.ebi.ac.uk/ena/data/view/X52837 ENZYME 2.3.1.16 http://enzyme.expasy.org/EC/2.3.1.16 EchoBASE EB0274 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0274 EcoGene EG10278 http://www.ecogene.org/geneInfo.php?eg_id=EG10278 EnsemblBacteria AAT48230 http://www.ensemblgenomes.org/id/AAT48230 EnsemblBacteria AAT48230 http://www.ensemblgenomes.org/id/AAT48230 EnsemblBacteria BAE77458 http://www.ensemblgenomes.org/id/BAE77458 EnsemblBacteria BAE77458 http://www.ensemblgenomes.org/id/BAE77458 EnsemblBacteria BAE77458 http://www.ensemblgenomes.org/id/BAE77458 EnsemblBacteria b3845 http://www.ensemblgenomes.org/id/b3845 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003988 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003988 GO_process GO:0006635 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006635 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.47.10 http://www.cathdb.info/version/latest/superfamily/3.40.47.10 GeneID 948324 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948324 HAMAP MF_01620 http://hamap.expasy.org/unirule/MF_01620 HOGENOM HOG000012239 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000012239&db=HOGENOM6 InParanoid P21151 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P21151 IntEnz 2.3.1.16 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.16 InterPro IPR002155 http://www.ebi.ac.uk/interpro/entry/IPR002155 InterPro IPR012805 http://www.ebi.ac.uk/interpro/entry/IPR012805 InterPro IPR016039 http://www.ebi.ac.uk/interpro/entry/IPR016039 InterPro IPR020610 http://www.ebi.ac.uk/interpro/entry/IPR020610 InterPro IPR020613 http://www.ebi.ac.uk/interpro/entry/IPR020613 InterPro IPR020615 http://www.ebi.ac.uk/interpro/entry/IPR020615 InterPro IPR020616 http://www.ebi.ac.uk/interpro/entry/IPR020616 InterPro IPR020617 http://www.ebi.ac.uk/interpro/entry/IPR020617 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5578 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5578 KEGG_Gene eco:b3845 http://www.genome.jp/dbget-bin/www_bget?eco:b3845 KEGG_Orthology KO:K00632 http://www.genome.jp/dbget-bin/www_bget?KO:K00632 KEGG_Pathway ko00071 http://www.genome.jp/kegg-bin/show_pathway?ko00071 KEGG_Pathway ko00280 http://www.genome.jp/kegg-bin/show_pathway?ko00280 KEGG_Pathway ko00281 http://www.genome.jp/kegg-bin/show_pathway?ko00281 KEGG_Pathway ko00362 http://www.genome.jp/kegg-bin/show_pathway?ko00362 KEGG_Pathway ko00592 http://www.genome.jp/kegg-bin/show_pathway?ko00592 KEGG_Pathway ko00642 http://www.genome.jp/kegg-bin/show_pathway?ko00642 KEGG_Reaction rn:R00829 http://www.genome.jp/dbget-bin/www_bget?rn:R00829 KEGG_Reaction rn:R00927 http://www.genome.jp/dbget-bin/www_bget?rn:R00927 KEGG_Reaction rn:R01177 http://www.genome.jp/dbget-bin/www_bget?rn:R01177 KEGG_Reaction rn:R03778 http://www.genome.jp/dbget-bin/www_bget?rn:R03778 KEGG_Reaction rn:R03858 http://www.genome.jp/dbget-bin/www_bget?rn:R03858 KEGG_Reaction rn:R03991 http://www.genome.jp/dbget-bin/www_bget?rn:R03991 KEGG_Reaction rn:R04546 http://www.genome.jp/dbget-bin/www_bget?rn:R04546 KEGG_Reaction rn:R04742 http://www.genome.jp/dbget-bin/www_bget?rn:R04742 KEGG_Reaction rn:R04747 http://www.genome.jp/dbget-bin/www_bget?rn:R04747 KEGG_Reaction rn:R05506 http://www.genome.jp/dbget-bin/www_bget?rn:R05506 KEGG_Reaction rn:R07891 http://www.genome.jp/dbget-bin/www_bget?rn:R07891 KEGG_Reaction rn:R07895 http://www.genome.jp/dbget-bin/www_bget?rn:R07895 KEGG_Reaction rn:R07899 http://www.genome.jp/dbget-bin/www_bget?rn:R07899 KEGG_Reaction rn:R08091 http://www.genome.jp/dbget-bin/www_bget?rn:R08091 KEGG_Reaction rn:R08095 http://www.genome.jp/dbget-bin/www_bget?rn:R08095 OMA PQGKEDG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PQGKEDG PROSITE PS00098 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00098 PROSITE PS00099 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00099 PROSITE PS00737 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00737 PSORT swissprot:FADA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FADA_ECOLI PSORT-B swissprot:FADA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FADA_ECOLI PSORT2 swissprot:FADA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FADA_ECOLI Pfam PF00108 http://pfam.xfam.org/family/PF00108 Pfam PF02803 http://pfam.xfam.org/family/PF02803 Phobius swissprot:FADA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FADA_ECOLI PhylomeDB P21151 http://phylomedb.org/?seqid=P21151 ProteinModelPortal P21151 http://www.proteinmodelportal.org/query/uniprot/P21151 PubMed 12535077 http://www.ncbi.nlm.nih.gov/pubmed/12535077 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1699931 http://www.ncbi.nlm.nih.gov/pubmed/1699931 PubMed 2191949 http://www.ncbi.nlm.nih.gov/pubmed/2191949 PubMed 2204034 http://www.ncbi.nlm.nih.gov/pubmed/2204034 PubMed 368024 http://www.ncbi.nlm.nih.gov/pubmed/368024 PubMed 8454629 http://www.ncbi.nlm.nih.gov/pubmed/8454629 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq WP_000438725 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000438725 RefSeq YP_026272 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026272 SMR P21151 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P21151 STRING 511145.b3845 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3845&targetmode=cogs STRING COG0183 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0183&targetmode=cogs SUPFAM SSF53901 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53901 TIGRFAMs TIGR01930 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01930 TIGRFAMs TIGR02445 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02445 UniProtKB FADA_ECOLI http://www.uniprot.org/uniprot/FADA_ECOLI UniProtKB-AC P21151 http://www.uniprot.org/uniprot/P21151 charge swissprot:FADA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FADA_ECOLI eggNOG COG0183 http://eggnogapi.embl.de/nog_data/html/tree/COG0183 eggNOG ENOG4105CHU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CHU epestfind swissprot:FADA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FADA_ECOLI garnier swissprot:FADA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FADA_ECOLI helixturnhelix swissprot:FADA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FADA_ECOLI hmoment swissprot:FADA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FADA_ECOLI iep swissprot:FADA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FADA_ECOLI inforesidue swissprot:FADA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FADA_ECOLI octanol swissprot:FADA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FADA_ECOLI pepcoil swissprot:FADA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FADA_ECOLI pepdigest swissprot:FADA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FADA_ECOLI pepinfo swissprot:FADA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FADA_ECOLI pepnet swissprot:FADA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FADA_ECOLI pepstats swissprot:FADA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FADA_ECOLI pepwheel swissprot:FADA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FADA_ECOLI pepwindow swissprot:FADA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FADA_ECOLI sigcleave swissprot:FADA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FADA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259258 7 # EcoGene EG12748 yhaI # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR008523 DUF805 # Organism YHAI_ECOLI Escherichia coli (strain K12) # PATRIC 32121628 VBIEscCol129921_3200 # PIR E65099 E65099 # Pfam PF05656 DUF805 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHAI_ECOLI Inner membrane protein YhaI # RefSeq NP_417575 NC_000913.3 # RefSeq WP_001198807 NZ_LN832404.1 # SIMILARITY To E.coli YhaH. {ECO 0000305}. # SUBCELLULAR LOCATION YHAI_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 9.B.124.1 the duf805 or pf05656 (duf805) family # eggNOG COG3152 LUCA # eggNOG ENOG4105KAF Bacteria BLAST swissprot:YHAI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHAI_ECOLI BioCyc ECOL316407:JW3075-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3075-MONOMER BioCyc EcoCyc:G7618-MONOMER http://biocyc.org/getid?id=EcoCyc:G7618-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2604 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2604 EcoGene EG12748 http://www.ecogene.org/geneInfo.php?eg_id=EG12748 EnsemblBacteria AAC76139 http://www.ensemblgenomes.org/id/AAC76139 EnsemblBacteria AAC76139 http://www.ensemblgenomes.org/id/AAC76139 EnsemblBacteria BAE77154 http://www.ensemblgenomes.org/id/BAE77154 EnsemblBacteria BAE77154 http://www.ensemblgenomes.org/id/BAE77154 EnsemblBacteria BAE77154 http://www.ensemblgenomes.org/id/BAE77154 EnsemblBacteria b3104 http://www.ensemblgenomes.org/id/b3104 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 947612 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947612 HOGENOM HOG000253106 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000253106&db=HOGENOM6 InParanoid P64592 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P64592 InterPro IPR008523 http://www.ebi.ac.uk/interpro/entry/IPR008523 KEGG_Gene ecj:JW3075 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3075 KEGG_Gene eco:b3104 http://www.genome.jp/dbget-bin/www_bget?eco:b3104 OMA WQLIGLI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WQLIGLI PSORT swissprot:YHAI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHAI_ECOLI PSORT-B swissprot:YHAI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHAI_ECOLI PSORT2 swissprot:YHAI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHAI_ECOLI Pfam PF05656 http://pfam.xfam.org/family/PF05656 Phobius swissprot:YHAI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHAI_ECOLI PhylomeDB P64592 http://phylomedb.org/?seqid=P64592 ProteinModelPortal P64592 http://www.proteinmodelportal.org/query/uniprot/P64592 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417575 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417575 RefSeq WP_001198807 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001198807 SMR P64592 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P64592 STRING 511145.b3104 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3104&targetmode=cogs TCDB 9.B.124.1 http://www.tcdb.org/search/result.php?tc=9.B.124.1 UniProtKB YHAI_ECOLI http://www.uniprot.org/uniprot/YHAI_ECOLI UniProtKB-AC P64592 http://www.uniprot.org/uniprot/P64592 charge swissprot:YHAI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHAI_ECOLI eggNOG COG3152 http://eggnogapi.embl.de/nog_data/html/tree/COG3152 eggNOG ENOG4105KAF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KAF epestfind swissprot:YHAI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHAI_ECOLI garnier swissprot:YHAI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHAI_ECOLI helixturnhelix swissprot:YHAI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHAI_ECOLI hmoment swissprot:YHAI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHAI_ECOLI iep swissprot:YHAI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHAI_ECOLI inforesidue swissprot:YHAI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHAI_ECOLI octanol swissprot:YHAI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHAI_ECOLI pepcoil swissprot:YHAI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHAI_ECOLI pepdigest swissprot:YHAI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHAI_ECOLI pepinfo swissprot:YHAI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHAI_ECOLI pepnet swissprot:YHAI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHAI_ECOLI pepstats swissprot:YHAI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHAI_ECOLI pepwheel swissprot:YHAI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHAI_ECOLI pepwindow swissprot:YHAI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHAI_ECOLI sigcleave swissprot:YHAI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHAI_ECOLI ## Database ID URL or Descriptions # AltName PTSN_ECOLI Enzyme IIA-NTR # AltName PTSN_ECOLI PTS system EIIA component # AltName PTSN_ECOLI Phosphotransferase enzyme IIA component # BioGrid 4259284 17 # DOMAIN PTSN_ECOLI The EIIA domain is phosphorylated by phospho-NPr on a histidyl residue. # EcoGene EG11682 ptsN # FUNCTION PTSN_ECOLI Seems to have a role in regulating nitrogen assimilation. {ECO 0000250}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004857 enzyme inhibitor activity; IMP:EcoCyc. # GO_function GO:0008982 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:InterPro. # GO_function GO:0016301 kinase activity; IEA:UniProtKB-KW. # GO_function GO:0030295 protein kinase activator activity; IDA:EcoCyc. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:InterPro. # GO_process GO:0010243 response to organonitrogen compound; IMP:EcoCyc. # GO_process GO:0032412 regulation of ion transmembrane transporter activity; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0030234 enzyme regulator activity # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # Gene3D 3.40.930.10 -; 1. # INTERACTION PTSN_ECOLI P21865 kdpD; NbExp=4; IntAct=EBI-547017, EBI-1123100; # IntAct P69829 9 # InterPro IPR002178 PTS_EIIA_type-2_dom # InterPro IPR006320 PTS_Nitro_regul # InterPro IPR016152 PTrfase/Anion_transptr # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02060 Phosphotransferase system (PTS) # Organism PTSN_ECOLI Escherichia coli (strain K12) # PATRIC 32121828 VBIEscCol129921_3298 # PDB 1A6J X-ray; 2.35 A; A/B=1-163 # PIR I76720 I76720 # PROSITE PS00372 PTS_EIIA_TYPE_2_HIS # PROSITE PS51094 PTS_EIIA_TYPE_2 # Pfam PF00359 PTS_EIIA_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PTSN_ECOLI Nitrogen regulatory protein # RefSeq NP_417671 NC_000913.3 # RefSeq WP_000183676 NZ_LN832404.1 # SIMILARITY Contains 1 PTS EIIA type-2 domain. {ECO:0000255|PROSITE-ProRule PRU00417}. # SUBCELLULAR LOCATION PTSN_ECOLI Cytoplasm. # SUPFAM SSF55804 SSF55804 # TIGRFAMs TIGR01419 nitro_reg_IIA # eggNOG COG1762 LUCA # eggNOG ENOG4107RM2 Bacteria BLAST swissprot:PTSN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTSN_ECOLI BioCyc ECOL316407:JW3171-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3171-MONOMER BioCyc EcoCyc:EG11682-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11682-MONOMER COG COG1762 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1762 DIP DIP-10604N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10604N DOI 10.1006/jmbi.1998.1753 http://dx.doi.org/10.1006/jmbi.1998.1753 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.270.9.4822 http://dx.doi.org/10.1074/jbc.270.9.4822 DOI 10.1099/13500872-140-5-1035 http://dx.doi.org/10.1099/13500872-140-5-1035 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D12938 http://www.ebi.ac.uk/ena/data/view/D12938 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U12684 http://www.ebi.ac.uk/ena/data/view/U12684 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL Z27094 http://www.ebi.ac.uk/ena/data/view/Z27094 ENZYME 2.7.1.- http://enzyme.expasy.org/EC/2.7.1.- EchoBASE EB1633 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1633 EcoGene EG11682 http://www.ecogene.org/geneInfo.php?eg_id=EG11682 EnsemblBacteria AAC76236 http://www.ensemblgenomes.org/id/AAC76236 EnsemblBacteria AAC76236 http://www.ensemblgenomes.org/id/AAC76236 EnsemblBacteria BAE77248 http://www.ensemblgenomes.org/id/BAE77248 EnsemblBacteria BAE77248 http://www.ensemblgenomes.org/id/BAE77248 EnsemblBacteria BAE77248 http://www.ensemblgenomes.org/id/BAE77248 EnsemblBacteria b3204 http://www.ensemblgenomes.org/id/b3204 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004857 GO_function GO:0008982 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008982 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_function GO:0030295 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030295 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GO_process GO:0010243 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010243 GO_process GO:0032412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032412 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.930.10 http://www.cathdb.info/version/latest/superfamily/3.40.930.10 GeneID 947721 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947721 HOGENOM HOG000227559 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000227559&db=HOGENOM6 InParanoid P69829 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P69829 IntAct P69829 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69829* IntEnz 2.7.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1 InterPro IPR002178 http://www.ebi.ac.uk/interpro/entry/IPR002178 InterPro IPR006320 http://www.ebi.ac.uk/interpro/entry/IPR006320 InterPro IPR016152 http://www.ebi.ac.uk/interpro/entry/IPR016152 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3171 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3171 KEGG_Gene eco:b3204 http://www.genome.jp/dbget-bin/www_bget?eco:b3204 KEGG_Orthology KO:K02806 http://www.genome.jp/dbget-bin/www_bget?KO:K02806 KEGG_Pathway ko02060 http://www.genome.jp/kegg-bin/show_pathway?ko02060 MINT MINT-1239820 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1239820 OMA PHCRLAG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PHCRLAG PDB 1A6J http://www.ebi.ac.uk/pdbe-srv/view/entry/1A6J PDBsum 1A6J http://www.ebi.ac.uk/pdbsum/1A6J PROSITE PS00372 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00372 PROSITE PS51094 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51094 PSORT swissprot:PTSN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTSN_ECOLI PSORT-B swissprot:PTSN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTSN_ECOLI PSORT2 swissprot:PTSN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTSN_ECOLI Pfam PF00359 http://pfam.xfam.org/family/PF00359 Phobius swissprot:PTSN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTSN_ECOLI PhylomeDB P69829 http://phylomedb.org/?seqid=P69829 ProteinModelPortal P69829 http://www.proteinmodelportal.org/query/uniprot/P69829 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7876255 http://www.ncbi.nlm.nih.gov/pubmed/7876255 PubMed 8025669 http://www.ncbi.nlm.nih.gov/pubmed/8025669 PubMed 8444818 http://www.ncbi.nlm.nih.gov/pubmed/8444818 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9636714 http://www.ncbi.nlm.nih.gov/pubmed/9636714 RefSeq NP_417671 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417671 RefSeq WP_000183676 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000183676 SMR P69829 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69829 STRING 511145.b3204 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3204&targetmode=cogs STRING COG1762 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1762&targetmode=cogs SUPFAM SSF55804 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55804 TIGRFAMs TIGR01419 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01419 UniProtKB PTSN_ECOLI http://www.uniprot.org/uniprot/PTSN_ECOLI UniProtKB-AC P69829 http://www.uniprot.org/uniprot/P69829 charge swissprot:PTSN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTSN_ECOLI eggNOG COG1762 http://eggnogapi.embl.de/nog_data/html/tree/COG1762 eggNOG ENOG4107RM2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107RM2 epestfind swissprot:PTSN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTSN_ECOLI garnier swissprot:PTSN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTSN_ECOLI helixturnhelix swissprot:PTSN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTSN_ECOLI hmoment swissprot:PTSN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTSN_ECOLI iep swissprot:PTSN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTSN_ECOLI inforesidue swissprot:PTSN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTSN_ECOLI octanol swissprot:PTSN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTSN_ECOLI pepcoil swissprot:PTSN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTSN_ECOLI pepdigest swissprot:PTSN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTSN_ECOLI pepinfo swissprot:PTSN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTSN_ECOLI pepnet swissprot:PTSN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTSN_ECOLI pepstats swissprot:PTSN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTSN_ECOLI pepwheel swissprot:PTSN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTSN_ECOLI pepwindow swissprot:PTSN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTSN_ECOLI sigcleave swissprot:PTSN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTSN_ECOLI ## Database ID URL or Descriptions # AltName MURB_ECOLI UDP-N-acetylmuramate dehydrogenase # BioGrid 4262982 592 # CATALYTIC ACTIVITY MURB_ECOLI UDP-N-acetyl-alpha-D-muramate + NADP(+) = UDP- N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH. # COFACTOR Name=FAD; Xref=ChEBI:CHEBI 57692; # DrugBank DB03147 Flavin adenine dinucleotide # EcoGene EG11205 murB # FUNCTION MURB_ECOLI Cell wall formation. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008762 UDP-N-acetylmuramate dehydrogenase activity; IDA:EcoCyc. # GO_function GO:0050660 flavin adenine dinucleotide binding; IDA:EcoliWiki. # GO_process GO:0007049 cell cycle; IEA:UniProtKB-KW. # GO_process GO:0008360 regulation of cell shape; IMP:EcoliWiki. # GO_process GO:0009252 peptidoglycan biosynthetic process; IMP:EcoliWiki. # GO_process GO:0051301 cell division; IEA:UniProtKB-KW. # GO_process GO:0071555 cell wall organization; IMP:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0007049 cell cycle # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0051301 cell division # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 3.30.43.10 -; 1. # Gene3D 3.30.465.10 -; 1. # Gene3D 3.90.78.10 -; 1. # HAMAP MF_00037 MurB # IntAct P08373 12 # InterPro IPR003170 MurB # InterPro IPR006094 Oxid_FAD_bind_N # InterPro IPR011601 MurB_C # InterPro IPR016166 FAD-bd_2 # InterPro IPR016167 FAD-bd_2_sub1 # InterPro IPR016169 CO_DH_flavot_FAD-bd_sub2 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00520 Amino sugar and nucleotide sugar metabolism # KEGG_Pathway ko00550 Peptidoglycan biosynthesis # Organism MURB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21071 PTHR21071 # PATHWAY MURB_ECOLI Cell wall biogenesis; peptidoglycan biosynthesis. # PATRIC 32123465 VBIEscCol129921_4089 # PDB 1MBB X-ray; 2.30 A; A=1-342 # PDB 1MBT X-ray; 3.00 A; A=1-342 # PDB 1UXY X-ray; 1.80 A; A=3-342 # PDB 2MBR X-ray; 1.80 A; A=3-342 # PDB 2Q85 X-ray; 2.51 A; A=1-342 # PIR A24029 QQECB8 # PROSITE PS51387 FAD_PCMH # Pfam PF01565 FAD_binding_4 # Pfam PF02873 MurB_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MURB_ECOLI UDP-N-acetylenolpyruvoylglucosamine reductase # RefSeq NP_418403 NC_000913.3 # RefSeq WP_001016699 NZ_LN832404.1 # SIMILARITY Belongs to the MurB family. {ECO 0000305}. # SIMILARITY Contains 1 FAD-binding PCMH-type domain. {ECO 0000305}. # SUBCELLULAR LOCATION MURB_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT MURB_ECOLI Monomer. # SUPFAM SSF56176 SSF56176 # SUPFAM SSF56194 SSF56194 # TIGRFAMs TIGR00179 murB # eggNOG COG0812 LUCA # eggNOG ENOG4105D4A Bacteria BLAST swissprot:MURB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MURB_ECOLI BioCyc ECOL316407:JW3940-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3940-MONOMER BioCyc EcoCyc:UDPNACETYLMURAMATEDEHYDROG-MONOMER http://biocyc.org/getid?id=EcoCyc:UDPNACETYLMURAMATEDEHYDROG-MONOMER BioCyc MetaCyc:UDPNACETYLMURAMATEDEHYDROG-MONOMER http://biocyc.org/getid?id=MetaCyc:UDPNACETYLMURAMATEDEHYDROG-MONOMER COG COG0812 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0812 DIP DIP-10277N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10277N DOI 10.1006/jmbi.1997.0915 http://dx.doi.org/10.1006/jmbi.1997.0915 DOI 10.1016/0022-2836(81)90508-8 http://dx.doi.org/10.1016/0022-2836(81)90508-8 DOI 10.1016/0378-1119(85)90011-3 http://dx.doi.org/10.1016/0378-1119(85)90011-3 DOI 10.1016/S0969-2126(96)00008-1 http://dx.doi.org/10.1016/S0969-2126(96)00008-1 DOI 10.1021/bi00059a019 http://dx.doi.org/10.1021/bi00059a019 DOI 10.1021/bi962221g http://dx.doi.org/10.1021/bi962221g DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB03147 http://www.drugbank.ca/drugs/DB03147 EC_number EC:1.3.1.98 http://www.genome.jp/dbget-bin/www_bget?EC:1.3.1.98 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L14557 http://www.ebi.ac.uk/ena/data/view/L14557 EMBL M10123 http://www.ebi.ac.uk/ena/data/view/M10123 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00348 http://www.ebi.ac.uk/ena/data/view/V00348 ENZYME 1.3.1.98 http://enzyme.expasy.org/EC/1.3.1.98 EchoBASE EB1190 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1190 EcoGene EG11205 http://www.ecogene.org/geneInfo.php?eg_id=EG11205 EnsemblBacteria AAC76950 http://www.ensemblgenomes.org/id/AAC76950 EnsemblBacteria AAC76950 http://www.ensemblgenomes.org/id/AAC76950 EnsemblBacteria BAE77343 http://www.ensemblgenomes.org/id/BAE77343 EnsemblBacteria BAE77343 http://www.ensemblgenomes.org/id/BAE77343 EnsemblBacteria BAE77343 http://www.ensemblgenomes.org/id/BAE77343 EnsemblBacteria b3972 http://www.ensemblgenomes.org/id/b3972 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008762 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008762 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0009252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009252 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 3.30.43.10 http://www.cathdb.info/version/latest/superfamily/3.30.43.10 Gene3D 3.30.465.10 http://www.cathdb.info/version/latest/superfamily/3.30.465.10 Gene3D 3.90.78.10 http://www.cathdb.info/version/latest/superfamily/3.90.78.10 GeneID 948470 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948470 HAMAP MF_00037 http://hamap.expasy.org/unirule/MF_00037 HOGENOM HOG000284356 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000284356&db=HOGENOM6 InParanoid P08373 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P08373 IntAct P08373 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P08373* IntEnz 1.3.1.98 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.3.1.98 InterPro IPR003170 http://www.ebi.ac.uk/interpro/entry/IPR003170 InterPro IPR006094 http://www.ebi.ac.uk/interpro/entry/IPR006094 InterPro IPR011601 http://www.ebi.ac.uk/interpro/entry/IPR011601 InterPro IPR016166 http://www.ebi.ac.uk/interpro/entry/IPR016166 InterPro IPR016167 http://www.ebi.ac.uk/interpro/entry/IPR016167 InterPro IPR016169 http://www.ebi.ac.uk/interpro/entry/IPR016169 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3940 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3940 KEGG_Gene eco:b3972 http://www.genome.jp/dbget-bin/www_bget?eco:b3972 KEGG_Orthology KO:K00075 http://www.genome.jp/dbget-bin/www_bget?KO:K00075 KEGG_Pathway ko00520 http://www.genome.jp/kegg-bin/show_pathway?ko00520 KEGG_Pathway ko00550 http://www.genome.jp/kegg-bin/show_pathway?ko00550 KEGG_Reaction rn:R03191 http://www.genome.jp/dbget-bin/www_bget?rn:R03191 KEGG_Reaction rn:R03192 http://www.genome.jp/dbget-bin/www_bget?rn:R03192 MINT MINT-1275566 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1275566 OMA MQNIGAY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MQNIGAY PANTHER PTHR21071 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21071 PDB 1MBB http://www.ebi.ac.uk/pdbe-srv/view/entry/1MBB PDB 1MBT http://www.ebi.ac.uk/pdbe-srv/view/entry/1MBT PDB 1UXY http://www.ebi.ac.uk/pdbe-srv/view/entry/1UXY PDB 2MBR http://www.ebi.ac.uk/pdbe-srv/view/entry/2MBR PDB 2Q85 http://www.ebi.ac.uk/pdbe-srv/view/entry/2Q85 PDBsum 1MBB http://www.ebi.ac.uk/pdbsum/1MBB PDBsum 1MBT http://www.ebi.ac.uk/pdbsum/1MBT PDBsum 1UXY http://www.ebi.ac.uk/pdbsum/1UXY PDBsum 2MBR http://www.ebi.ac.uk/pdbsum/2MBR PDBsum 2Q85 http://www.ebi.ac.uk/pdbsum/2Q85 PROSITE PS51387 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51387 PSORT swissprot:MURB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MURB_ECOLI PSORT-B swissprot:MURB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MURB_ECOLI PSORT2 swissprot:MURB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MURB_ECOLI Pfam PF01565 http://pfam.xfam.org/family/PF01565 Pfam PF02873 http://pfam.xfam.org/family/PF02873 Phobius swissprot:MURB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MURB_ECOLI PhylomeDB P08373 http://phylomedb.org/?seqid=P08373 ProteinModelPortal P08373 http://www.proteinmodelportal.org/query/uniprot/P08373 PubMed 1311302 http://www.ncbi.nlm.nih.gov/pubmed/1311302 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3899863 http://www.ncbi.nlm.nih.gov/pubmed/3899863 PubMed 7028991 http://www.ncbi.nlm.nih.gov/pubmed/7028991 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 8448160 http://www.ncbi.nlm.nih.gov/pubmed/8448160 PubMed 8805513 http://www.ncbi.nlm.nih.gov/pubmed/8805513 PubMed 9020778 http://www.ncbi.nlm.nih.gov/pubmed/9020778 PubMed 9150408 http://www.ncbi.nlm.nih.gov/pubmed/9150408 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418403 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418403 RefSeq WP_001016699 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001016699 SMR P08373 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P08373 STRING 511145.b3972 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3972&targetmode=cogs STRING COG0812 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0812&targetmode=cogs SUPFAM SSF56176 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56176 SUPFAM SSF56194 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56194 TIGRFAMs TIGR00179 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00179 UniProtKB MURB_ECOLI http://www.uniprot.org/uniprot/MURB_ECOLI UniProtKB-AC P08373 http://www.uniprot.org/uniprot/P08373 charge swissprot:MURB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MURB_ECOLI eggNOG COG0812 http://eggnogapi.embl.de/nog_data/html/tree/COG0812 eggNOG ENOG4105D4A http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D4A epestfind swissprot:MURB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MURB_ECOLI garnier swissprot:MURB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MURB_ECOLI helixturnhelix swissprot:MURB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MURB_ECOLI hmoment swissprot:MURB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MURB_ECOLI iep swissprot:MURB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MURB_ECOLI inforesidue swissprot:MURB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MURB_ECOLI octanol swissprot:MURB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MURB_ECOLI pepcoil swissprot:MURB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MURB_ECOLI pepdigest swissprot:MURB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MURB_ECOLI pepinfo swissprot:MURB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MURB_ECOLI pepnet swissprot:MURB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MURB_ECOLI pepstats swissprot:MURB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MURB_ECOLI pepwheel swissprot:MURB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MURB_ECOLI pepwindow swissprot:MURB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MURB_ECOLI sigcleave swissprot:MURB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MURB_ECOLI ## Database ID URL or Descriptions # BioGrid 4261161 9 # CDD cd07377 WHTH_GntR # EcoGene EG14066 yegW # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # Gene3D 3.40.1410.10 -; 1. # IntAct P0ACM5 2 # InterPro IPR000524 Tscrpt_reg_HTH_GntR # InterPro IPR011663 UTRA # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR028978 Chorismate_lyase_/UTRA_dom # Organism YEGW_ECOLI Escherichia coli (strain K12) # PATRIC 32119535 VBIEscCol129921_2178 # PIR D64977 D64977 # PRINTS PR00035 HTHGNTR # PROSITE PS50949 HTH_GNTR # Pfam PF00392 GntR # Pfam PF07702 UTRA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEGW_ECOLI Uncharacterized HTH-type transcriptional regulator YegW # RefSeq NP_416604 NC_000913.3 # RefSeq WP_000434038 NZ_LN832404.1 # SIMILARITY Contains 1 HTH gntR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00307}. # SMART SM00345 HTH_GNTR # SMART SM00866 UTRA # SUPFAM SSF46785 SSF46785 # SUPFAM SSF64288 SSF64288 # eggNOG COG2188 LUCA # eggNOG ENOG4105FDP Bacteria BLAST swissprot:YEGW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEGW_ECOLI BioCyc ECOL316407:JW2088-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2088-MONOMER BioCyc EcoCyc:G7133-MONOMER http://biocyc.org/getid?id=EcoCyc:G7133-MONOMER DIP DIP-11893N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11893N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3819 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3819 EcoGene EG14066 http://www.ecogene.org/geneInfo.php?eg_id=EG14066 EnsemblBacteria AAC75162 http://www.ensemblgenomes.org/id/AAC75162 EnsemblBacteria AAC75162 http://www.ensemblgenomes.org/id/AAC75162 EnsemblBacteria BAA15969 http://www.ensemblgenomes.org/id/BAA15969 EnsemblBacteria BAA15969 http://www.ensemblgenomes.org/id/BAA15969 EnsemblBacteria BAA15969 http://www.ensemblgenomes.org/id/BAA15969 EnsemblBacteria b2101 http://www.ensemblgenomes.org/id/b2101 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 3.40.1410.10 http://www.cathdb.info/version/latest/superfamily/3.40.1410.10 GeneID 946639 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946639 HOGENOM HOG000228717 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000228717&db=HOGENOM6 InParanoid P0ACM5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACM5 IntAct P0ACM5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACM5* InterPro IPR000524 http://www.ebi.ac.uk/interpro/entry/IPR000524 InterPro IPR011663 http://www.ebi.ac.uk/interpro/entry/IPR011663 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR028978 http://www.ebi.ac.uk/interpro/entry/IPR028978 KEGG_Gene ecj:JW2088 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2088 KEGG_Gene eco:b2101 http://www.genome.jp/dbget-bin/www_bget?eco:b2101 OMA EILEQDY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EILEQDY PRINTS PR00035 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00035 PROSITE PS50949 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50949 PSORT swissprot:YEGW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEGW_ECOLI PSORT-B swissprot:YEGW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEGW_ECOLI PSORT2 swissprot:YEGW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEGW_ECOLI Pfam PF00392 http://pfam.xfam.org/family/PF00392 Pfam PF07702 http://pfam.xfam.org/family/PF07702 Phobius swissprot:YEGW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEGW_ECOLI PhylomeDB P0ACM5 http://phylomedb.org/?seqid=P0ACM5 ProteinModelPortal P0ACM5 http://www.proteinmodelportal.org/query/uniprot/P0ACM5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416604 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416604 RefSeq WP_000434038 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000434038 SMART SM00345 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00345 SMART SM00866 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00866 SMR P0ACM5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACM5 STRING 511145.b2101 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2101&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SUPFAM SSF64288 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF64288 UniProtKB YEGW_ECOLI http://www.uniprot.org/uniprot/YEGW_ECOLI UniProtKB-AC P0ACM5 http://www.uniprot.org/uniprot/P0ACM5 charge swissprot:YEGW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEGW_ECOLI eggNOG COG2188 http://eggnogapi.embl.de/nog_data/html/tree/COG2188 eggNOG ENOG4105FDP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FDP epestfind swissprot:YEGW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEGW_ECOLI garnier swissprot:YEGW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEGW_ECOLI helixturnhelix swissprot:YEGW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEGW_ECOLI hmoment swissprot:YEGW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEGW_ECOLI iep swissprot:YEGW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEGW_ECOLI inforesidue swissprot:YEGW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEGW_ECOLI octanol swissprot:YEGW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEGW_ECOLI pepcoil swissprot:YEGW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEGW_ECOLI pepdigest swissprot:YEGW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEGW_ECOLI pepinfo swissprot:YEGW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEGW_ECOLI pepnet swissprot:YEGW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEGW_ECOLI pepstats swissprot:YEGW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEGW_ECOLI pepwheel swissprot:YEGW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEGW_ECOLI pepwindow swissprot:YEGW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEGW_ECOLI sigcleave swissprot:YEGW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEGW_ECOLI ## Database ID URL or Descriptions # CATALYTIC ACTIVITY DCEA_ECOLI L-glutamate = 4-aminobutanoate + CO(2). # COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI 597326; # EcoGene EG50009 gadA # FUNCTION DCEA_ECOLI Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0004351 glutamate decarboxylase activity; IDA:EcoCyc. # GO_function GO:0030170 pyridoxal phosphate binding; IEA:InterPro. # GO_process GO:0006536 glutamate metabolic process; IEA:InterPro. # GO_process GO:0051454 intracellular pH elevation; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0042592 homeostatic process # Gene3D 3.40.640.10 -; 1. # INDUCTION DCEA_ECOLI By acidic conditions. Expression is regulated by a complex system involving RpoS, cAMP, CRP, EvgAS, H-NS, GadE, GadW and GadX. The level of involvement for each regulator varies depending upon the growth phase and the medium. {ECO 0000269|PubMed 10383761, ECO 0000269|PubMed 11976288, ECO 0000269|PubMed 12399493, ECO 0000269|PubMed 12446650, ECO 0000269|PubMed 12694615, ECO 0000269|PubMed 12867478, ECO 0000269|PubMed 12940989}. # IntAct P69908 14 # InterPro IPR002129 PyrdxlP-dep_de-COase # InterPro IPR010107 Glutamate_decarboxylase # InterPro IPR015421 PyrdxlP-dep_Trfase_major_sub1 # InterPro IPR015424 PyrdxlP-dep_Trfase # InterPro IPR021115 Pyridoxal-P_BS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00250 Alanine, aspartate and glutamate metabolism # KEGG_Pathway ko00410 beta-Alanine metabolism # KEGG_Pathway ko00430 Taurine and hypotaurine metabolism # KEGG_Pathway ko00650 Butanoate metabolism # KEGG_Pathway ko04727 GABAergic synapse # KEGG_Pathway ko04940 Type I diabetes mellitus # Organism DCEA_ECOLI Escherichia coli (strain K12) # PATRIC 32122496 VBIEscCol129921_3626 # PDB 1XEY X-ray; 2.05 A; A/B=1-466 # PIR S47737 S24234 # PROSITE PS00392 DDC_GAD_HDC_YDC # Pfam PF00282 Pyridoxal_deC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DCEA_ECOLI Glutamate decarboxylase alpha # RefSeq NP_417974 NC_000913.3 # RefSeq WP_000372240 NZ_LN832404.1 # SIMILARITY Belongs to the group II decarboxylase family. {ECO 0000305}. # SUBUNIT DCEA_ECOLI Homohexamer. # SUPFAM SSF53383 SSF53383 # TIGRFAMs TIGR01788 Glu-decarb-GAD # WEB RESOURCE DCEA_ECOLI Name=Worthington enzyme manual; URL="http //www.worthington-biochem.com/GLDP/"; # eggNOG COG0076 LUCA # eggNOG ENOG4105CVK Bacteria BLAST swissprot:DCEA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DCEA_ECOLI BioCyc ECOL316407:JW3485-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3485-MONOMER BioCyc EcoCyc:GLUTDECARBOXA-MONOMER http://biocyc.org/getid?id=EcoCyc:GLUTDECARBOXA-MONOMER BioCyc MetaCyc:GLUTDECARBOXA-MONOMER http://biocyc.org/getid?id=MetaCyc:GLUTDECARBOXA-MONOMER COG COG0076 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0076 DIP DIP-36201N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36201N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1999.01430.x http://dx.doi.org/10.1046/j.1365-2958.1999.01430.x DOI 10.1046/j.1365-2958.2003.03477.x http://dx.doi.org/10.1046/j.1365-2958.2003.03477.x DOI 10.1046/j.1365-2958.2003.03633.x http://dx.doi.org/10.1046/j.1365-2958.2003.03633.x DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1111/j.1432-1033.1992.tb16609.x http://dx.doi.org/10.1111/j.1432-1033.1992.tb16609.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.10.2603-2613.2002 http://dx.doi.org/10.1128/JB.184.10.2603-2613.2002 DOI 10.1128/JB.184.22.6225-6234.2002 http://dx.doi.org/10.1128/JB.184.22.6225-6234.2002 DOI 10.1128/JB.184.24.7001-7012.2002 http://dx.doi.org/10.1128/JB.184.24.7001-7012.2002 DOI 10.1128/JB.185.15.4644-4647.2003 http://dx.doi.org/10.1128/JB.185.15.4644-4647.2003 DOI 10.1271/bbb.57.1568 http://dx.doi.org/10.1271/bbb.57.1568 EC_number EC:4.1.1.15 http://www.genome.jp/dbget-bin/www_bget?EC:4.1.1.15 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M84024 http://www.ebi.ac.uk/ena/data/view/M84024 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X63123 http://www.ebi.ac.uk/ena/data/view/X63123 ENZYME 4.1.1.15 http://enzyme.expasy.org/EC/4.1.1.15 EchoBASE EB4302 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4302 EcoGene EG50009 http://www.ecogene.org/geneInfo.php?eg_id=EG50009 EnsemblBacteria AAC76542 http://www.ensemblgenomes.org/id/AAC76542 EnsemblBacteria AAC76542 http://www.ensemblgenomes.org/id/AAC76542 EnsemblBacteria BAE77777 http://www.ensemblgenomes.org/id/BAE77777 EnsemblBacteria BAE77777 http://www.ensemblgenomes.org/id/BAE77777 EnsemblBacteria BAE77777 http://www.ensemblgenomes.org/id/BAE77777 EnsemblBacteria b3517 http://www.ensemblgenomes.org/id/b3517 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0004351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004351 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_process GO:0006536 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006536 GO_process GO:0051454 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051454 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 Gene3D 3.40.640.10 http://www.cathdb.info/version/latest/superfamily/3.40.640.10 GeneID 948027 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948027 HOGENOM HOG000070228 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000070228&db=HOGENOM6 InParanoid P69908 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P69908 IntAct P69908 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69908* IntEnz 4.1.1.15 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.1.15 InterPro IPR002129 http://www.ebi.ac.uk/interpro/entry/IPR002129 InterPro IPR010107 http://www.ebi.ac.uk/interpro/entry/IPR010107 InterPro IPR015421 http://www.ebi.ac.uk/interpro/entry/IPR015421 InterPro IPR015424 http://www.ebi.ac.uk/interpro/entry/IPR015424 InterPro IPR021115 http://www.ebi.ac.uk/interpro/entry/IPR021115 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3485 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3485 KEGG_Gene eco:b3517 http://www.genome.jp/dbget-bin/www_bget?eco:b3517 KEGG_Orthology KO:K01580 http://www.genome.jp/dbget-bin/www_bget?KO:K01580 KEGG_Pathway ko00250 http://www.genome.jp/kegg-bin/show_pathway?ko00250 KEGG_Pathway ko00410 http://www.genome.jp/kegg-bin/show_pathway?ko00410 KEGG_Pathway ko00430 http://www.genome.jp/kegg-bin/show_pathway?ko00430 KEGG_Pathway ko00650 http://www.genome.jp/kegg-bin/show_pathway?ko00650 KEGG_Pathway ko04727 http://www.genome.jp/kegg-bin/show_pathway?ko04727 KEGG_Pathway ko04940 http://www.genome.jp/kegg-bin/show_pathway?ko04940 KEGG_Reaction rn:R00261 http://www.genome.jp/dbget-bin/www_bget?rn:R00261 KEGG_Reaction rn:R00489 http://www.genome.jp/dbget-bin/www_bget?rn:R00489 KEGG_Reaction rn:R01682 http://www.genome.jp/dbget-bin/www_bget?rn:R01682 KEGG_Reaction rn:R02466 http://www.genome.jp/dbget-bin/www_bget?rn:R02466 MINT MINT-1224142 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1224142 OMA YTGRLFT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YTGRLFT PDB 1XEY http://www.ebi.ac.uk/pdbe-srv/view/entry/1XEY PDBsum 1XEY http://www.ebi.ac.uk/pdbsum/1XEY PROSITE PS00392 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00392 PSORT swissprot:DCEA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DCEA_ECOLI PSORT-B swissprot:DCEA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DCEA_ECOLI PSORT2 swissprot:DCEA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DCEA_ECOLI Pfam PF00282 http://pfam.xfam.org/family/PF00282 Phobius swissprot:DCEA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DCEA_ECOLI PhylomeDB P69908 http://phylomedb.org/?seqid=P69908 ProteinModelPortal P69908 http://www.proteinmodelportal.org/query/uniprot/P69908 PubMed 10383761 http://www.ncbi.nlm.nih.gov/pubmed/10383761 PubMed 11976288 http://www.ncbi.nlm.nih.gov/pubmed/11976288 PubMed 12399493 http://www.ncbi.nlm.nih.gov/pubmed/12399493 PubMed 12446650 http://www.ncbi.nlm.nih.gov/pubmed/12446650 PubMed 12694615 http://www.ncbi.nlm.nih.gov/pubmed/12694615 PubMed 12867478 http://www.ncbi.nlm.nih.gov/pubmed/12867478 PubMed 12940989 http://www.ncbi.nlm.nih.gov/pubmed/12940989 PubMed 1522060 http://www.ncbi.nlm.nih.gov/pubmed/1522060 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1740158 http://www.ncbi.nlm.nih.gov/pubmed/1740158 PubMed 7764225 http://www.ncbi.nlm.nih.gov/pubmed/7764225 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_417974 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417974 RefSeq WP_000372240 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000372240 SMR P69908 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69908 STRING 511145.b3517 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3517&targetmode=cogs STRING COG0076 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0076&targetmode=cogs SUPFAM SSF53383 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53383 TIGRFAMs TIGR01788 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01788 UniProtKB DCEA_ECOLI http://www.uniprot.org/uniprot/DCEA_ECOLI UniProtKB-AC P69908 http://www.uniprot.org/uniprot/P69908 charge swissprot:DCEA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DCEA_ECOLI eggNOG COG0076 http://eggnogapi.embl.de/nog_data/html/tree/COG0076 eggNOG ENOG4105CVK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CVK epestfind swissprot:DCEA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DCEA_ECOLI garnier swissprot:DCEA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DCEA_ECOLI helixturnhelix swissprot:DCEA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DCEA_ECOLI hmoment swissprot:DCEA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DCEA_ECOLI iep swissprot:DCEA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DCEA_ECOLI inforesidue swissprot:DCEA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DCEA_ECOLI octanol swissprot:DCEA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DCEA_ECOLI pepcoil swissprot:DCEA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DCEA_ECOLI pepdigest swissprot:DCEA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DCEA_ECOLI pepinfo swissprot:DCEA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DCEA_ECOLI pepnet swissprot:DCEA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DCEA_ECOLI pepstats swissprot:DCEA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DCEA_ECOLI pepwheel swissprot:DCEA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DCEA_ECOLI pepwindow swissprot:DCEA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DCEA_ECOLI sigcleave swissprot:DCEA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DCEA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261496 10 # EcoGene EG12555 sgcQ # GO_function GO:0003824 catalytic activity; IEA:InterPro. # GO_process GO:0008152 metabolic process; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0008150 biological_process # InterPro IPR005137 PSI_BtpA # InterPro IPR011060 RibuloseP-bd_barrel # Organism SGCQ_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21381 PTHR21381 # PATRIC 32124192 VBIEscCol129921_4439 # PIR S56528 S56528 # PIRSF PIRSF005956 BtpA # Pfam PF03437 BtpA # ProDom PD011184 PSI_BtpA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SGCQ_ECOLI Putative sgc region protein SgcQ # RefSeq NP_418723 NC_000913.3 # RefSeq WP_000118626 NZ_LN832404.1 # SIMILARITY Belongs to the BtpA family. {ECO 0000305}. # SUPFAM SSF51366 SSF51366 # TIGRFAMs TIGR00259 thylakoid_BtpA # eggNOG COG0434 LUCA # eggNOG ENOG4106P19 Bacteria BLAST swissprot:SGCQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SGCQ_ECOLI BioCyc ECOL316407:JW4265-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4265-MONOMER BioCyc EcoCyc:G7915-MONOMER http://biocyc.org/getid?id=EcoCyc:G7915-MONOMER COG COG0434 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0434 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2443 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2443 EcoGene EG12555 http://www.ecogene.org/geneInfo.php?eg_id=EG12555 EnsemblBacteria AAC77259 http://www.ensemblgenomes.org/id/AAC77259 EnsemblBacteria AAC77259 http://www.ensemblgenomes.org/id/AAC77259 EnsemblBacteria BAE78294 http://www.ensemblgenomes.org/id/BAE78294 EnsemblBacteria BAE78294 http://www.ensemblgenomes.org/id/BAE78294 EnsemblBacteria BAE78294 http://www.ensemblgenomes.org/id/BAE78294 EnsemblBacteria b4303 http://www.ensemblgenomes.org/id/b4303 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003824 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003824 GO_process GO:0008152 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008152 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 948834 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948834 HOGENOM HOG000077119 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000077119&db=HOGENOM6 InParanoid P39364 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39364 IntAct P39364 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39364* InterPro IPR005137 http://www.ebi.ac.uk/interpro/entry/IPR005137 InterPro IPR011060 http://www.ebi.ac.uk/interpro/entry/IPR011060 KEGG_Gene ecj:JW4265 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4265 KEGG_Gene eco:b4303 http://www.genome.jp/dbget-bin/www_bget?eco:b4303 KEGG_Orthology KO:K06971 http://www.genome.jp/dbget-bin/www_bget?KO:K06971 OMA ENFFDAP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ENFFDAP PANTHER PTHR21381 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21381 PSORT swissprot:SGCQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SGCQ_ECOLI PSORT-B swissprot:SGCQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SGCQ_ECOLI PSORT2 swissprot:SGCQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SGCQ_ECOLI Pfam PF03437 http://pfam.xfam.org/family/PF03437 Phobius swissprot:SGCQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SGCQ_ECOLI PhylomeDB P39364 http://phylomedb.org/?seqid=P39364 ProteinModelPortal P39364 http://www.proteinmodelportal.org/query/uniprot/P39364 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418723 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418723 RefSeq WP_000118626 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000118626 STRING 511145.b4303 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4303&targetmode=cogs STRING COG0434 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0434&targetmode=cogs SUPFAM SSF51366 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51366 TIGRFAMs TIGR00259 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00259 UniProtKB SGCQ_ECOLI http://www.uniprot.org/uniprot/SGCQ_ECOLI UniProtKB-AC P39364 http://www.uniprot.org/uniprot/P39364 charge swissprot:SGCQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SGCQ_ECOLI eggNOG COG0434 http://eggnogapi.embl.de/nog_data/html/tree/COG0434 eggNOG ENOG4106P19 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106P19 epestfind swissprot:SGCQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SGCQ_ECOLI garnier swissprot:SGCQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SGCQ_ECOLI helixturnhelix swissprot:SGCQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SGCQ_ECOLI hmoment swissprot:SGCQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SGCQ_ECOLI iep swissprot:SGCQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SGCQ_ECOLI inforesidue swissprot:SGCQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SGCQ_ECOLI octanol swissprot:SGCQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SGCQ_ECOLI pepcoil swissprot:SGCQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SGCQ_ECOLI pepdigest swissprot:SGCQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SGCQ_ECOLI pepinfo swissprot:SGCQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SGCQ_ECOLI pepnet swissprot:SGCQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SGCQ_ECOLI pepstats swissprot:SGCQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SGCQ_ECOLI pepwheel swissprot:SGCQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SGCQ_ECOLI pepwindow swissprot:SGCQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SGCQ_ECOLI sigcleave swissprot:SGCQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SGCQ_ECOLI ## Database ID URL or Descriptions # EcoGene EG14305 yoaG # Gene3D 3.30.160.220 -; 1. # InterPro IPR015051 YoaG # Organism YOAG_ECOLI Escherichia coli (strain K12) # PATRIC 32118907 VBIEscCol129921_1871 # PDB 1NEI NMR; -; A/B=1-60 # PIR D64940 D64940 # Pfam PF08956 DUF1869 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YOAG_ECOLI Protein YoaG # RefSeq NP_416310 NC_000913.3 # RefSeq WP_000513737 NZ_LN832404.1 # SUBUNIT Homodimer. {ECO 0000269|Ref.3}. # SUPFAM SSF103063 SSF103063 # eggNOG ENOG4105YP6 Bacteria # eggNOG ENOG41126SD LUCA BLAST swissprot:YOAG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YOAG_ECOLI BioCyc ECOL316407:JW1785-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1785-MONOMER BioCyc EcoCyc:G6982-MONOMER http://biocyc.org/getid?id=EcoCyc:G6982-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4052 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4052 EcoGene EG14305 http://www.ecogene.org/geneInfo.php?eg_id=EG14305 EnsemblBacteria AAC74866 http://www.ensemblgenomes.org/id/AAC74866 EnsemblBacteria AAC74866 http://www.ensemblgenomes.org/id/AAC74866 EnsemblBacteria BAE76532 http://www.ensemblgenomes.org/id/BAE76532 EnsemblBacteria BAE76532 http://www.ensemblgenomes.org/id/BAE76532 EnsemblBacteria BAE76532 http://www.ensemblgenomes.org/id/BAE76532 EnsemblBacteria b1796 http://www.ensemblgenomes.org/id/b1796 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.30.160.220 http://www.cathdb.info/version/latest/superfamily/3.30.160.220 GeneID 946314 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946314 HOGENOM HOG000267924 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267924&db=HOGENOM6 InterPro IPR015051 http://www.ebi.ac.uk/interpro/entry/IPR015051 KEGG_Gene ecj:JW1785 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1785 KEGG_Gene eco:b1796 http://www.genome.jp/dbget-bin/www_bget?eco:b1796 OMA PMELLIP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PMELLIP PDB 1NEI http://www.ebi.ac.uk/pdbe-srv/view/entry/1NEI PDBsum 1NEI http://www.ebi.ac.uk/pdbsum/1NEI PSORT swissprot:YOAG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YOAG_ECOLI PSORT-B swissprot:YOAG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YOAG_ECOLI PSORT2 swissprot:YOAG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YOAG_ECOLI Pfam PF08956 http://pfam.xfam.org/family/PF08956 Phobius swissprot:YOAG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YOAG_ECOLI ProteinModelPortal P64496 http://www.proteinmodelportal.org/query/uniprot/P64496 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416310 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416310 RefSeq WP_000513737 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000513737 SMR P64496 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P64496 STRING 511145.b1796 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1796&targetmode=cogs SUPFAM SSF103063 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103063 UniProtKB YOAG_ECOLI http://www.uniprot.org/uniprot/YOAG_ECOLI UniProtKB-AC P64496 http://www.uniprot.org/uniprot/P64496 charge swissprot:YOAG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YOAG_ECOLI eggNOG ENOG4105YP6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105YP6 eggNOG ENOG41126SD http://eggnogapi.embl.de/nog_data/html/tree/ENOG41126SD epestfind swissprot:YOAG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YOAG_ECOLI garnier swissprot:YOAG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YOAG_ECOLI helixturnhelix swissprot:YOAG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YOAG_ECOLI hmoment swissprot:YOAG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YOAG_ECOLI iep swissprot:YOAG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YOAG_ECOLI inforesidue swissprot:YOAG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YOAG_ECOLI octanol swissprot:YOAG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YOAG_ECOLI pepcoil swissprot:YOAG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YOAG_ECOLI pepdigest swissprot:YOAG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YOAG_ECOLI pepinfo swissprot:YOAG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YOAG_ECOLI pepnet swissprot:YOAG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YOAG_ECOLI pepstats swissprot:YOAG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YOAG_ECOLI pepwheel swissprot:YOAG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YOAG_ECOLI pepwindow swissprot:YOAG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YOAG_ECOLI sigcleave swissprot:YOAG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YOAG_ECOLI ## Database ID URL or Descriptions # BioGrid 4263295 13 # CDD cd03418 GRX_GRXb_1_3_like # EcoGene EG12294 grxC # FUNCTION GLRX3_ECOLI The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfide bonds in a coupled system with glutathione reductase. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0009055 electron carrier activity; IEA:InterPro. # GO_function GO:0015035 protein disulfide oxidoreductase activity; IDA:EcoCyc. # GO_function GO:0043295 glutathione binding; IDA:EcoCyc. # GO_process GO:0009263 deoxyribonucleotide biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0045454 cell redox homeostasis; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0042592 homeostatic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.30.10 -; 1. # IntAct P0AC62 2 # InterPro IPR002109 Glutaredoxin # InterPro IPR011767 GLR_AS # InterPro IPR011900 GRX_bact # InterPro IPR012336 Thioredoxin-like_fold # InterPro IPR014025 Glutaredoxin_subgr # KEGG_Brite ko03110 Chaperones and folding catalysts # Organism GLRX3_ECOLI Escherichia coli (strain K12) # PATRIC 32122705 VBIEscCol129921_3729 # PDB 1FOV NMR; -; A=2-83 # PDB 1ILB Model; -; A=1-83 # PDB 1UQ8 Model; -; G=2-83 # PDB 1UQ9 Model; -; G=2-83 # PDB 1UQI Model; -; G=2-83 # PDB 1UQJ Model; -; G=2-83 # PDB 1UQK Model; -; G=2-83 # PDB 1UQL Model; -; G=2-83 # PDB 1UQM Model; -; G=2-83 # PDB 1UQO Model; -; G=2-83 # PDB 1UQP Model; -; G=2-83 # PDB 1UQQ Model; -; G=2-83 # PDB 3GRX NMR; -; A=2-83 # PIR S47831 S47831 # PRINTS PR00160 GLUTAREDOXIN # PROSITE PS00195 GLUTAREDOXIN_1 # PROSITE PS51354 GLUTAREDOXIN_2 # Pfam PF00462 Glutaredoxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLRX3_ECOLI Glutaredoxin-3 # RefSeq NP_418067 NC_000913.3 # RefSeq WP_000024392 NZ_LN832404.1 # SIMILARITY Belongs to the glutaredoxin family. {ECO 0000305}. # SIMILARITY Contains 1 glutaredoxin domain. {ECO:0000255|PROSITE- ProRule PRU00686}. # SUBUNIT Monomer. {ECO 0000305}. # SUPFAM SSF52833 SSF52833 # TIGRFAMs TIGR02181 GRX_bact # eggNOG COG0695 LUCA # eggNOG ENOG4105VW4 Bacteria BLAST swissprot:GLRX3_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLRX3_ECOLI BioCyc ECOL316407:JW3585-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3585-MONOMER BioCyc EcoCyc:GRXC-MONOMER http://biocyc.org/getid?id=EcoCyc:GRXC-MONOMER COG COG0695 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0695 DOI 10.1006/jmbi.1998.2444 http://dx.doi.org/10.1006/jmbi.1998.2444 DOI 10.1006/jmbi.2000.4145 http://dx.doi.org/10.1006/jmbi.2000.4145 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.91.21.9813 http://dx.doi.org/10.1073/pnas.91.21.9813 DOI 10.1074/jbc.271.12.6736 http://dx.doi.org/10.1074/jbc.271.12.6736 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2202 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2202 EcoGene EG12294 http://www.ecogene.org/geneInfo.php?eg_id=EG12294 EnsemblBacteria AAC76634 http://www.ensemblgenomes.org/id/AAC76634 EnsemblBacteria AAC76634 http://www.ensemblgenomes.org/id/AAC76634 EnsemblBacteria BAE77682 http://www.ensemblgenomes.org/id/BAE77682 EnsemblBacteria BAE77682 http://www.ensemblgenomes.org/id/BAE77682 EnsemblBacteria BAE77682 http://www.ensemblgenomes.org/id/BAE77682 EnsemblBacteria b3610 http://www.ensemblgenomes.org/id/b3610 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0015035 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015035 GO_function GO:0043295 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043295 GO_process GO:0009263 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009263 GO_process GO:0045454 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045454 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.30.10 http://www.cathdb.info/version/latest/superfamily/3.40.30.10 GeneID 948132 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948132 HOGENOM HOG000095203 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000095203&db=HOGENOM6 InParanoid P0AC62 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AC62 IntAct P0AC62 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AC62* InterPro IPR002109 http://www.ebi.ac.uk/interpro/entry/IPR002109 InterPro IPR011767 http://www.ebi.ac.uk/interpro/entry/IPR011767 InterPro IPR011900 http://www.ebi.ac.uk/interpro/entry/IPR011900 InterPro IPR012336 http://www.ebi.ac.uk/interpro/entry/IPR012336 InterPro IPR014025 http://www.ebi.ac.uk/interpro/entry/IPR014025 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW3585 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3585 KEGG_Gene eco:b3610 http://www.genome.jp/dbget-bin/www_bget?eco:b3610 KEGG_Orthology KO:K03676 http://www.genome.jp/dbget-bin/www_bget?KO:K03676 OMA GYCTAAK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GYCTAAK PDB 1FOV http://www.ebi.ac.uk/pdbe-srv/view/entry/1FOV PDB 1ILB http://www.ebi.ac.uk/pdbe-srv/view/entry/1ILB PDB 1UQ8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1UQ8 PDB 1UQ9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1UQ9 PDB 1UQI http://www.ebi.ac.uk/pdbe-srv/view/entry/1UQI PDB 1UQJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1UQJ PDB 1UQK http://www.ebi.ac.uk/pdbe-srv/view/entry/1UQK PDB 1UQL http://www.ebi.ac.uk/pdbe-srv/view/entry/1UQL PDB 1UQM http://www.ebi.ac.uk/pdbe-srv/view/entry/1UQM PDB 1UQO http://www.ebi.ac.uk/pdbe-srv/view/entry/1UQO PDB 1UQP http://www.ebi.ac.uk/pdbe-srv/view/entry/1UQP PDB 1UQQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1UQQ PDB 3GRX http://www.ebi.ac.uk/pdbe-srv/view/entry/3GRX PDBsum 1FOV http://www.ebi.ac.uk/pdbsum/1FOV PDBsum 1ILB http://www.ebi.ac.uk/pdbsum/1ILB PDBsum 1UQ8 http://www.ebi.ac.uk/pdbsum/1UQ8 PDBsum 1UQ9 http://www.ebi.ac.uk/pdbsum/1UQ9 PDBsum 1UQI http://www.ebi.ac.uk/pdbsum/1UQI PDBsum 1UQJ http://www.ebi.ac.uk/pdbsum/1UQJ PDBsum 1UQK http://www.ebi.ac.uk/pdbsum/1UQK PDBsum 1UQL http://www.ebi.ac.uk/pdbsum/1UQL PDBsum 1UQM http://www.ebi.ac.uk/pdbsum/1UQM PDBsum 1UQO http://www.ebi.ac.uk/pdbsum/1UQO PDBsum 1UQP http://www.ebi.ac.uk/pdbsum/1UQP PDBsum 1UQQ http://www.ebi.ac.uk/pdbsum/1UQQ PDBsum 3GRX http://www.ebi.ac.uk/pdbsum/3GRX PRINTS PR00160 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00160 PROSITE PS00195 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00195 PROSITE PS51354 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51354 PSORT swissprot:GLRX3_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLRX3_ECOLI PSORT-B swissprot:GLRX3_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLRX3_ECOLI PSORT2 swissprot:GLRX3_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLRX3_ECOLI Pfam PF00462 http://pfam.xfam.org/family/PF00462 Phobius swissprot:GLRX3_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLRX3_ECOLI PhylomeDB P0AC62 http://phylomedb.org/?seqid=P0AC62 ProteinModelPortal P0AC62 http://www.proteinmodelportal.org/query/uniprot/P0AC62 PubMed 11031118 http://www.ncbi.nlm.nih.gov/pubmed/11031118 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7937896 http://www.ncbi.nlm.nih.gov/pubmed/7937896 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 8636094 http://www.ncbi.nlm.nih.gov/pubmed/8636094 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9973569 http://www.ncbi.nlm.nih.gov/pubmed/9973569 RefSeq NP_418067 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418067 RefSeq WP_000024392 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000024392 SMR P0AC62 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AC62 STRING 511145.b3610 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3610&targetmode=cogs STRING COG0695 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0695&targetmode=cogs SUPFAM SSF52833 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52833 TIGRFAMs TIGR02181 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02181 UniProtKB GLRX3_ECOLI http://www.uniprot.org/uniprot/GLRX3_ECOLI UniProtKB-AC P0AC62 http://www.uniprot.org/uniprot/P0AC62 charge swissprot:GLRX3_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLRX3_ECOLI eggNOG COG0695 http://eggnogapi.embl.de/nog_data/html/tree/COG0695 eggNOG ENOG4105VW4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VW4 epestfind swissprot:GLRX3_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLRX3_ECOLI garnier swissprot:GLRX3_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLRX3_ECOLI helixturnhelix swissprot:GLRX3_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLRX3_ECOLI hmoment swissprot:GLRX3_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLRX3_ECOLI iep swissprot:GLRX3_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLRX3_ECOLI inforesidue swissprot:GLRX3_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLRX3_ECOLI octanol swissprot:GLRX3_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLRX3_ECOLI pepcoil swissprot:GLRX3_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLRX3_ECOLI pepdigest swissprot:GLRX3_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLRX3_ECOLI pepinfo swissprot:GLRX3_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLRX3_ECOLI pepnet swissprot:GLRX3_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLRX3_ECOLI pepstats swissprot:GLRX3_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLRX3_ECOLI pepwheel swissprot:GLRX3_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLRX3_ECOLI pepwindow swissprot:GLRX3_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLRX3_ECOLI sigcleave swissprot:GLRX3_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLRX3_ECOLI ## Database ID URL or Descriptions # BioGrid 4262784 6 # COFACTOR Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI 49601; Note=Binds 1 [2Fe-2S] cluster.; # EcoGene EG12595 fhuF # FUNCTION FHUF_ECOLI Involved in the reduction of ferric iron in cytoplasmic ferrioxamine B. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051537 2 iron, 2 sulfur cluster binding; IDA:EcoCyc. # GO_process GO:0033212 iron assimilation; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0042592 homeostatic process # INDUCTION Induced 2.4-fold by hydroxyurea. {ECO:0000269|PubMed 20005847}. # IntAct P39405 18 # InterPro IPR008090 Fe_iron_reduct # InterPro IPR022770 FhuF_domain # InterPro IPR024726 FhuF_C # Organism FHUF_ECOLI Escherichia coli (strain K12) # PATRIC 32124342 VBIEscCol129921_4514 # PIR S56594 S56594 # PRINTS PR01714 2FE2SRDCTASE # Pfam PF06276 FhuF # Pfam PF11575 FhuF_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FHUF_ECOLI Ferric iron reductase protein FhuF # RefSeq NP_418787 NC_000913.3 # RefSeq WP_000331618 NZ_LN832404.1 # SUBCELLULAR LOCATION FHUF_ECOLI Cytoplasm. Cell membrane; Peripheral membrane protein. # TIGRFAMs TIGR03951 Fe_III_red_FhuF # eggNOG COG4114 LUCA # eggNOG ENOG4108819 Bacteria BLAST swissprot:FHUF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FHUF_ECOLI BioCyc ECOL316407:JW4331-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4331-MONOMER BioCyc EcoCyc:G7949-MONOMER http://biocyc.org/getid?id=EcoCyc:G7949-MONOMER COG COG4114 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4114 DIP DIP-9607N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9607N DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1432-1327.1998.2581001.x http://dx.doi.org/10.1046/j.1432-1327.1998.2581001.x DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2480 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2480 EcoGene EG12595 http://www.ecogene.org/geneInfo.php?eg_id=EG12595 EnsemblBacteria AAC77323 http://www.ensemblgenomes.org/id/AAC77323 EnsemblBacteria AAC77323 http://www.ensemblgenomes.org/id/AAC77323 EnsemblBacteria BAE78357 http://www.ensemblgenomes.org/id/BAE78357 EnsemblBacteria BAE78357 http://www.ensemblgenomes.org/id/BAE78357 EnsemblBacteria BAE78357 http://www.ensemblgenomes.org/id/BAE78357 EnsemblBacteria b4367 http://www.ensemblgenomes.org/id/b4367 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051537 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051537 GO_process GO:0033212 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033212 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GeneID 948891 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948891 HOGENOM HOG000127617 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000127617&db=HOGENOM6 IntAct P39405 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39405* InterPro IPR008090 http://www.ebi.ac.uk/interpro/entry/IPR008090 InterPro IPR022770 http://www.ebi.ac.uk/interpro/entry/IPR022770 InterPro IPR024726 http://www.ebi.ac.uk/interpro/entry/IPR024726 KEGG_Gene ecj:JW4331 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4331 KEGG_Gene eco:b4367 http://www.genome.jp/dbget-bin/www_bget?eco:b4367 KEGG_Orthology KO:K13255 http://www.genome.jp/dbget-bin/www_bget?KO:K13255 OMA SPEHFHV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SPEHFHV PRINTS PR01714 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01714 PSORT swissprot:FHUF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FHUF_ECOLI PSORT-B swissprot:FHUF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FHUF_ECOLI PSORT2 swissprot:FHUF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FHUF_ECOLI Pfam PF06276 http://pfam.xfam.org/family/PF06276 Pfam PF11575 http://pfam.xfam.org/family/PF11575 Phobius swissprot:FHUF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FHUF_ECOLI ProteinModelPortal P39405 http://www.proteinmodelportal.org/query/uniprot/P39405 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9990318 http://www.ncbi.nlm.nih.gov/pubmed/9990318 RefSeq NP_418787 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418787 RefSeq WP_000331618 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000331618 STRING 511145.b4367 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4367&targetmode=cogs STRING COG4114 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4114&targetmode=cogs TIGRFAMs TIGR03951 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03951 UniProtKB FHUF_ECOLI http://www.uniprot.org/uniprot/FHUF_ECOLI UniProtKB-AC P39405 http://www.uniprot.org/uniprot/P39405 charge swissprot:FHUF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FHUF_ECOLI eggNOG COG4114 http://eggnogapi.embl.de/nog_data/html/tree/COG4114 eggNOG ENOG4108819 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108819 epestfind swissprot:FHUF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FHUF_ECOLI garnier swissprot:FHUF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FHUF_ECOLI helixturnhelix swissprot:FHUF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FHUF_ECOLI hmoment swissprot:FHUF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FHUF_ECOLI iep swissprot:FHUF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FHUF_ECOLI inforesidue swissprot:FHUF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FHUF_ECOLI octanol swissprot:FHUF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FHUF_ECOLI pepcoil swissprot:FHUF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FHUF_ECOLI pepdigest swissprot:FHUF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FHUF_ECOLI pepinfo swissprot:FHUF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FHUF_ECOLI pepnet swissprot:FHUF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FHUF_ECOLI pepstats swissprot:FHUF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FHUF_ECOLI pepwheel swissprot:FHUF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FHUF_ECOLI pepwindow swissprot:FHUF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FHUF_ECOLI sigcleave swissprot:FHUF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FHUF_ECOLI ## Database ID URL or Descriptions # BioGrid 4262562 134 # DOMAIN RHSA_ECOLI Each rhs appears to consist of a highly conserved 141 kDa amino fragment followed by a highly divergent C-terminus. # EcoGene EG10846 rhsA # FUNCTION RHSA_ECOLI Rhs elements have a nonessential function. They may play an important role in the natural ecology of the cell. # GO_process GO:0097264 self proteolysis; IEA:InterPro. # GOslim_process GO:0008150 biological_process # IntAct P16916 27 # InterPro IPR001826 RHS # InterPro IPR006530 YD # InterPro IPR022385 Rhs_assc_core # InterPro IPR028947 Ntox34 # InterPro IPR031325 RHS_repeat # Organism RHSA_ECOLI Escherichia coli (strain K12) # PATRIC 32122666 VBIEscCol129921_3710 # PIR C65159 C65159 # PRINTS PR00394 RHSPROTEIN # Pfam PF03527 RHS # Pfam PF05593 RHS_repeat; 7 # Pfam PF15606 Ntox34 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RHSA_ECOLI Protein RhsA # RefSeq NP_418050 NC_000913.3 # RefSeq WP_000015300 NZ_LN832404.1 # SIMILARITY Belongs to the RHS family. {ECO 0000305}. # TIGRFAMs TIGR01643 YD_repeat_2x; 5 # TIGRFAMs TIGR03696 Rhs_assc_core # eggNOG COG3209 LUCA # eggNOG ENOG4105CNA Bacteria BLAST swissprot:RHSA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RHSA_ECOLI BioCyc ECOL316407:JW3566-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3566-MONOMER BioCyc EcoCyc:EG10846-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10846-MONOMER DIP DIP-10699N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10699N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1111/j.1365-2958.1994.tb01074.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb01074.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19044 http://www.ebi.ac.uk/ena/data/view/L19044 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0839 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0839 EcoGene EG10846 http://www.ecogene.org/geneInfo.php?eg_id=EG10846 EnsemblBacteria AAC76617 http://www.ensemblgenomes.org/id/AAC76617 EnsemblBacteria AAC76617 http://www.ensemblgenomes.org/id/AAC76617 EnsemblBacteria BAE77700 http://www.ensemblgenomes.org/id/BAE77700 EnsemblBacteria BAE77700 http://www.ensemblgenomes.org/id/BAE77700 EnsemblBacteria BAE77700 http://www.ensemblgenomes.org/id/BAE77700 EnsemblBacteria b3593 http://www.ensemblgenomes.org/id/b3593 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0097264 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097264 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 948120 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948120 HOGENOM HOG000225201 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000225201&db=HOGENOM6 InParanoid P16916 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P16916 IntAct P16916 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P16916* InterPro IPR001826 http://www.ebi.ac.uk/interpro/entry/IPR001826 InterPro IPR006530 http://www.ebi.ac.uk/interpro/entry/IPR006530 InterPro IPR022385 http://www.ebi.ac.uk/interpro/entry/IPR022385 InterPro IPR028947 http://www.ebi.ac.uk/interpro/entry/IPR028947 InterPro IPR031325 http://www.ebi.ac.uk/interpro/entry/IPR031325 KEGG_Gene ecj:JW3566 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3566 KEGG_Gene eco:b3593 http://www.genome.jp/dbget-bin/www_bget?eco:b3593 MINT MINT-1242055 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1242055 OMA ERYYYSW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ERYYYSW PRINTS PR00394 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00394 PSORT swissprot:RHSA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RHSA_ECOLI PSORT-B swissprot:RHSA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RHSA_ECOLI PSORT2 swissprot:RHSA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RHSA_ECOLI Pfam PF03527 http://pfam.xfam.org/family/PF03527 Pfam PF05593 http://pfam.xfam.org/family/PF05593 Pfam PF15606 http://pfam.xfam.org/family/PF15606 Phobius swissprot:RHSA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RHSA_ECOLI PhylomeDB P16916 http://phylomedb.org/?seqid=P16916 ProteinModelPortal P16916 http://www.proteinmodelportal.org/query/uniprot/P16916 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2403547 http://www.ncbi.nlm.nih.gov/pubmed/2403547 PubMed 7934896 http://www.ncbi.nlm.nih.gov/pubmed/7934896 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418050 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418050 RefSeq WP_000015300 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000015300 SMR P16916 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P16916 STRING 511145.b3593 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3593&targetmode=cogs TIGRFAMs TIGR01643 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01643 TIGRFAMs TIGR03696 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03696 UniProtKB RHSA_ECOLI http://www.uniprot.org/uniprot/RHSA_ECOLI UniProtKB-AC P16916 http://www.uniprot.org/uniprot/P16916 charge swissprot:RHSA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RHSA_ECOLI eggNOG COG3209 http://eggnogapi.embl.de/nog_data/html/tree/COG3209 eggNOG ENOG4105CNA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CNA epestfind swissprot:RHSA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RHSA_ECOLI garnier swissprot:RHSA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RHSA_ECOLI helixturnhelix swissprot:RHSA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RHSA_ECOLI hmoment swissprot:RHSA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RHSA_ECOLI iep swissprot:RHSA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RHSA_ECOLI inforesidue swissprot:RHSA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RHSA_ECOLI octanol swissprot:RHSA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RHSA_ECOLI pepcoil swissprot:RHSA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RHSA_ECOLI pepdigest swissprot:RHSA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RHSA_ECOLI pepinfo swissprot:RHSA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RHSA_ECOLI pepnet swissprot:RHSA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RHSA_ECOLI pepstats swissprot:RHSA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RHSA_ECOLI pepwheel swissprot:RHSA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RHSA_ECOLI pepwindow swissprot:RHSA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RHSA_ECOLI sigcleave swissprot:RHSA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RHSA_ECOLI ## Database ID URL or Descriptions # EcoGene EG14065 yegV # GO_function GO:0004747 ribokinase activity; IEA:InterPro. # GO_process GO:0006014 D-ribose metabolic process; IEA:InterPro. # GOslim_function GO:0016301 kinase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.1190.20 -; 1. # IntAct P76419 11 # InterPro IPR002139 Ribo/fructo_kinase # InterPro IPR002173 Carboh/pur_kinase_PfkB_CS # InterPro IPR011611 PfkB_dom # InterPro IPR029056 Ribokinase-like # Organism YEGV_ECOLI Escherichia coli (strain K12) # PATRIC 32119533 VBIEscCol129921_2177 # PIR C64977 C64977 # PRINTS PR00990 RIBOKINASE # PROSITE PS00583 PFKB_KINASES_1 # PROSITE PS00584 PFKB_KINASES_2 # Pfam PF00294 PfkB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEGV_ECOLI Uncharacterized sugar kinase YegV # RefSeq NP_416603 NC_000913.3 # RefSeq WP_000012001 NZ_LN832404.1 # SIMILARITY Belongs to the carbohydrate kinase PfkB family. {ECO 0000305}. # SUPFAM SSF53613 SSF53613 # eggNOG COG0524 LUCA # eggNOG ENOG4108TFM Bacteria BLAST swissprot:YEGV_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEGV_ECOLI BioCyc ECOL316407:JW2087-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2087-MONOMER BioCyc EcoCyc:G7132-MONOMER http://biocyc.org/getid?id=EcoCyc:G7132-MONOMER DIP DIP-11892N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11892N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.- http://enzyme.expasy.org/EC/2.7.1.- EchoBASE EB3818 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3818 EcoGene EG14065 http://www.ecogene.org/geneInfo.php?eg_id=EG14065 EnsemblBacteria AAC75161 http://www.ensemblgenomes.org/id/AAC75161 EnsemblBacteria AAC75161 http://www.ensemblgenomes.org/id/AAC75161 EnsemblBacteria BAA15968 http://www.ensemblgenomes.org/id/BAA15968 EnsemblBacteria BAA15968 http://www.ensemblgenomes.org/id/BAA15968 EnsemblBacteria BAA15968 http://www.ensemblgenomes.org/id/BAA15968 EnsemblBacteria b2100 http://www.ensemblgenomes.org/id/b2100 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004747 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004747 GO_process GO:0006014 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006014 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.1190.20 http://www.cathdb.info/version/latest/superfamily/3.40.1190.20 GeneID 946637 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946637 HOGENOM HOG000235950 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000235950&db=HOGENOM6 InParanoid P76419 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76419 IntAct P76419 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76419* IntEnz 2.7.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1 InterPro IPR002139 http://www.ebi.ac.uk/interpro/entry/IPR002139 InterPro IPR002173 http://www.ebi.ac.uk/interpro/entry/IPR002173 InterPro IPR011611 http://www.ebi.ac.uk/interpro/entry/IPR011611 InterPro IPR029056 http://www.ebi.ac.uk/interpro/entry/IPR029056 KEGG_Gene ecj:JW2087 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2087 KEGG_Gene eco:b2100 http://www.genome.jp/dbget-bin/www_bget?eco:b2100 OMA NIGGCAL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NIGGCAL PRINTS PR00990 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00990 PROSITE PS00583 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00583 PROSITE PS00584 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00584 PSORT swissprot:YEGV_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEGV_ECOLI PSORT-B swissprot:YEGV_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEGV_ECOLI PSORT2 swissprot:YEGV_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEGV_ECOLI Pfam PF00294 http://pfam.xfam.org/family/PF00294 Phobius swissprot:YEGV_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEGV_ECOLI PhylomeDB P76419 http://phylomedb.org/?seqid=P76419 ProteinModelPortal P76419 http://www.proteinmodelportal.org/query/uniprot/P76419 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416603 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416603 RefSeq WP_000012001 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000012001 SMR P76419 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76419 STRING 511145.b2100 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2100&targetmode=cogs SUPFAM SSF53613 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53613 UniProtKB YEGV_ECOLI http://www.uniprot.org/uniprot/YEGV_ECOLI UniProtKB-AC P76419 http://www.uniprot.org/uniprot/P76419 charge swissprot:YEGV_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEGV_ECOLI eggNOG COG0524 http://eggnogapi.embl.de/nog_data/html/tree/COG0524 eggNOG ENOG4108TFM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108TFM epestfind swissprot:YEGV_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEGV_ECOLI garnier swissprot:YEGV_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEGV_ECOLI helixturnhelix swissprot:YEGV_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEGV_ECOLI hmoment swissprot:YEGV_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEGV_ECOLI iep swissprot:YEGV_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEGV_ECOLI inforesidue swissprot:YEGV_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEGV_ECOLI octanol swissprot:YEGV_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEGV_ECOLI pepcoil swissprot:YEGV_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEGV_ECOLI pepdigest swissprot:YEGV_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEGV_ECOLI pepinfo swissprot:YEGV_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEGV_ECOLI pepnet swissprot:YEGV_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEGV_ECOLI pepstats swissprot:YEGV_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEGV_ECOLI pepwheel swissprot:YEGV_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEGV_ECOLI pepwindow swissprot:YEGV_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEGV_ECOLI sigcleave swissprot:YEGV_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEGV_ECOLI ## Database ID URL or Descriptions # AltName HCAB_ECOLI 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase # AltName HCAB_ECOLI 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase # AltName HCAB_ECOLI CI-dihydrodiol dehydrogenase # AltName HCAB_ECOLI Cis-3-(2-carboxyethenyl)-3,5-cyclohexadiene-1,2-diol dehydrogenase # AltName HCAB_ECOLI Cis-3-(2-carboxyethyl)-3,5-cyclohexadiene-1,2-diol dehydrogenase # AltName HCAB_ECOLI PP-dihydrodiol dehydrogenase # BioGrid 4260604 7 # CATALYTIC ACTIVITY (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1- yl)prop-2-enoate + NAD(+) = (2E)-3-(2,3-dihydroxyphenyl)prop-2- enoate + NADH. {ECO:0000269|PubMed 9603882}. # CATALYTIC ACTIVITY 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1- yl)propanoate + NAD(+) = 3-(2,3-dihydroxyphenyl)propanoate + NADH. {ECO:0000269|PubMed 9603882}. # EcoGene EG13459 hcaB # FUNCTION HCAB_ECOLI Converts 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol) into 3-(2,3- dihydroxylphenyl)propanoic acid (DHPP) and 2,3-dihydroxicinnamic acid (DHCI), respectively. {ECO 0000250, ECO 0000269|PubMed 9603882}. # GO_function GO:0018498 2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase activity; IEA:UniProtKB-HAMAP. # GO_process GO:0019380 3-phenylpropionate catabolic process; IMP:EcoCyc. # GO_process GO:0019439 aromatic compound catabolic process; IEA:UniProtKB-HAMAP. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.720 -; 1. # HAMAP MF_01647 HcaB # IntAct P0CI31 7 # InterPro IPR002347 SDR_fam # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR020904 Sc_DH/Rdtase_CS # InterPro IPR023643 Dihydrodiol_DH_HcaB # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00360 Phenylalanine metabolism # Organism HCAB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR24322 PTHR24322; 2 # PATHWAY HCAB_ECOLI Aromatic compound metabolism; 3-phenylpropanoate degradation. # PATRIC 32120479 VBIEscCol129921_2642 # PIR D65031 D65031 # PRINTS PR00080 SDRFAMILY # PRINTS PR00081 GDHRDH # PROSITE PS00061 ADH_SHORT # Pfam PF00106 adh_short # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HCAB_ECOLI 3-phenylpropionate-dihydrodiol/cinnamic acid-dihydrodiol dehydrogenase # RefSeq NP_417036 NC_000913.3 # RefSeq WP_001281379 NZ_LN832404.1 # SIMILARITY Belongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO 0000305}. # SUPFAM SSF51735 SSF51735 # eggNOG ENOG4108QJ2 Bacteria # eggNOG ENOG410XQCB LUCA BLAST swissprot:HCAB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HCAB_ECOLI BioCyc EcoCyc:PHENPRODIOLDEHYDROG-MONOMER http://biocyc.org/getid?id=EcoCyc:PHENPRODIOLDEHYDROG-MONOMER BioCyc MetaCyc:PHENPRODIOLDEHYDROG-MONOMER http://biocyc.org/getid?id=MetaCyc:PHENPRODIOLDEHYDROG-MONOMER COG COG1028 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1028 DIP DIP-9863N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9863N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.3.1.87 http://www.genome.jp/dbget-bin/www_bget?EC:1.3.1.87 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.3.1.87 http://enzyme.expasy.org/EC/1.3.1.87 EchoBASE EB3232 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3232 EcoGene EG13459 http://www.ecogene.org/geneInfo.php?eg_id=EG13459 EnsemblBacteria AAC75594 http://www.ensemblgenomes.org/id/AAC75594 EnsemblBacteria AAC75594 http://www.ensemblgenomes.org/id/AAC75594 EnsemblBacteria BAA16444 http://www.ensemblgenomes.org/id/BAA16444 EnsemblBacteria BAA16444 http://www.ensemblgenomes.org/id/BAA16444 EnsemblBacteria BAA16444 http://www.ensemblgenomes.org/id/BAA16444 EnsemblBacteria b2541 http://www.ensemblgenomes.org/id/b2541 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0018498 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018498 GO_process GO:0019380 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019380 GO_process GO:0019439 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019439 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 945346 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945346 HAMAP MF_01647 http://hamap.expasy.org/unirule/MF_01647 InParanoid P0CI31 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CI31 IntAct P0CI31 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0CI31* IntEnz 1.3.1.87 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.3.1.87 InterPro IPR002347 http://www.ebi.ac.uk/interpro/entry/IPR002347 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR020904 http://www.ebi.ac.uk/interpro/entry/IPR020904 InterPro IPR023643 http://www.ebi.ac.uk/interpro/entry/IPR023643 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2525 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2525 KEGG_Gene eco:b2541 http://www.genome.jp/dbget-bin/www_bget?eco:b2541 KEGG_Orthology KO:K05711 http://www.genome.jp/dbget-bin/www_bget?KO:K05711 KEGG_Pathway ko00360 http://www.genome.jp/kegg-bin/show_pathway?ko00360 KEGG_Reaction rn:R06784 http://www.genome.jp/dbget-bin/www_bget?rn:R06784 KEGG_Reaction rn:R06785 http://www.genome.jp/dbget-bin/www_bget?rn:R06785 MINT MINT-1239788 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1239788 OMA EVFHINV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EVFHINV PANTHER PTHR24322 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24322 PRINTS PR00080 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00080 PRINTS PR00081 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00081 PROSITE PS00061 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00061 PSORT swissprot:HCAB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HCAB_ECOLI PSORT-B swissprot:HCAB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HCAB_ECOLI PSORT2 swissprot:HCAB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HCAB_ECOLI Pfam PF00106 http://pfam.xfam.org/family/PF00106 Phobius swissprot:HCAB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HCAB_ECOLI PhylomeDB P0CI31 http://phylomedb.org/?seqid=P0CI31 ProteinModelPortal P0CI31 http://www.proteinmodelportal.org/query/uniprot/P0CI31 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9603882 http://www.ncbi.nlm.nih.gov/pubmed/9603882 RefSeq NP_417036 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417036 RefSeq WP_001281379 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001281379 SMR P0CI31 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0CI31 STRING 511145.b2541 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2541&targetmode=cogs STRING COG1028 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1028&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB HCAB_ECOLI http://www.uniprot.org/uniprot/HCAB_ECOLI UniProtKB-AC P0CI31 http://www.uniprot.org/uniprot/P0CI31 charge swissprot:HCAB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HCAB_ECOLI eggNOG ENOG4108QJ2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108QJ2 eggNOG ENOG410XQCB http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQCB epestfind swissprot:HCAB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HCAB_ECOLI garnier swissprot:HCAB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HCAB_ECOLI helixturnhelix swissprot:HCAB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HCAB_ECOLI hmoment swissprot:HCAB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HCAB_ECOLI iep swissprot:HCAB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HCAB_ECOLI inforesidue swissprot:HCAB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HCAB_ECOLI octanol swissprot:HCAB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HCAB_ECOLI pepcoil swissprot:HCAB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HCAB_ECOLI pepdigest swissprot:HCAB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HCAB_ECOLI pepinfo swissprot:HCAB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HCAB_ECOLI pepnet swissprot:HCAB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HCAB_ECOLI pepstats swissprot:HCAB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HCAB_ECOLI pepwheel swissprot:HCAB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HCAB_ECOLI pepwindow swissprot:HCAB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HCAB_ECOLI sigcleave swissprot:HCAB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HCAB_ECOLI ## Database ID URL or Descriptions # BioGrid 4262340 10 # COFACTOR Name=FMN; Xref=ChEBI:CHEBI 58210; # EcoGene EG12697 fldB # FUNCTION FLAW_ECOLI Low-potential electron donor to a number of redox enzymes. {ECO 0000305}. # GO_function GO:0009055 electron carrier activity; IEA:InterPro. # GO_function GO:0010181 FMN binding; IDA:EcoCyc. # GO_process GO:0055114 oxidation-reduction process; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.360 -; 1. # IntAct P0ABY4 8 # InterPro IPR001226 Flavodoxin_CS # InterPro IPR008254 Flavodoxin/NO_synth # InterPro IPR010086 Flavodoxin_lc # InterPro IPR029039 Flavoprotein-like_dom # Organism FLAW_ECOLI Escherichia coli (strain K12) # PATRIC 32121202 VBIEscCol129921_2989 # PDB 2MT9 NMR; -; A=1-173 # PDB 2MTB NMR; -; A=1-173 # PIR G65073 G65073 # PIRSF PIRSF038996 FldA # PROSITE PS00201 FLAVODOXIN # PROSITE PS50902 FLAVODOXIN_LIKE # Pfam PF00258 Flavodoxin_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FLAW_ECOLI Flavodoxin-2 # RefSeq NP_417371 NC_000913.3 # RefSeq WP_001055874 NZ_LN832404.1 # SIMILARITY Belongs to the flavodoxin family. {ECO 0000305}. # SIMILARITY Contains 1 flavodoxin-like domain. {ECO:0000255|PROSITE-ProRule PRU00088}. # SUPFAM SSF52218 SSF52218 # TIGRFAMs TIGR01752 flav_long # eggNOG COG0716 LUCA # eggNOG ENOG41071R3 Bacteria BLAST swissprot:FLAW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLAW_ECOLI BioCyc ECOL316407:JW2863-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2863-MONOMER BioCyc EcoCyc:FLAVODOXIN2-MONOMER http://biocyc.org/getid?id=EcoCyc:FLAVODOXIN2-MONOMER COG COG0716 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0716 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 EMBL Z48060 http://www.ebi.ac.uk/ena/data/view/Z48060 EchoBASE EB2559 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2559 EcoGene EG12697 http://www.ecogene.org/geneInfo.php?eg_id=EG12697 EnsemblBacteria AAC75933 http://www.ensemblgenomes.org/id/AAC75933 EnsemblBacteria AAC75933 http://www.ensemblgenomes.org/id/AAC75933 EnsemblBacteria BAE76960 http://www.ensemblgenomes.org/id/BAE76960 EnsemblBacteria BAE76960 http://www.ensemblgenomes.org/id/BAE76960 EnsemblBacteria BAE76960 http://www.ensemblgenomes.org/id/BAE76960 EnsemblBacteria b2895 http://www.ensemblgenomes.org/id/b2895 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0010181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010181 GO_process GO:0055114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.360 http://www.cathdb.info/version/latest/superfamily/3.40.50.360 GeneID 947361 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947361 HOGENOM HOG000030543 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000030543&db=HOGENOM6 InParanoid P0ABY4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABY4 IntAct P0ABY4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABY4* InterPro IPR001226 http://www.ebi.ac.uk/interpro/entry/IPR001226 InterPro IPR008254 http://www.ebi.ac.uk/interpro/entry/IPR008254 InterPro IPR010086 http://www.ebi.ac.uk/interpro/entry/IPR010086 InterPro IPR029039 http://www.ebi.ac.uk/interpro/entry/IPR029039 KEGG_Gene ecj:JW2863 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2863 KEGG_Gene eco:b2895 http://www.genome.jp/dbget-bin/www_bget?eco:b2895 KEGG_Orthology KO:K03840 http://www.genome.jp/dbget-bin/www_bget?KO:K03840 OMA ILGISTW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ILGISTW PDB 2MT9 http://www.ebi.ac.uk/pdbe-srv/view/entry/2MT9 PDB 2MTB http://www.ebi.ac.uk/pdbe-srv/view/entry/2MTB PDBsum 2MT9 http://www.ebi.ac.uk/pdbsum/2MT9 PDBsum 2MTB http://www.ebi.ac.uk/pdbsum/2MTB PROSITE PS00201 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00201 PROSITE PS50902 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50902 PSORT swissprot:FLAW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLAW_ECOLI PSORT-B swissprot:FLAW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLAW_ECOLI PSORT2 swissprot:FLAW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLAW_ECOLI Pfam PF00258 http://pfam.xfam.org/family/PF00258 Phobius swissprot:FLAW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLAW_ECOLI PhylomeDB P0ABY4 http://phylomedb.org/?seqid=P0ABY4 ProteinModelPortal P0ABY4 http://www.proteinmodelportal.org/query/uniprot/P0ABY4 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417371 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417371 RefSeq WP_001055874 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001055874 SMR P0ABY4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABY4 STRING 511145.b2895 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2895&targetmode=cogs STRING COG0716 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0716&targetmode=cogs SUPFAM SSF52218 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52218 TIGRFAMs TIGR01752 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01752 UniProtKB FLAW_ECOLI http://www.uniprot.org/uniprot/FLAW_ECOLI UniProtKB-AC P0ABY4 http://www.uniprot.org/uniprot/P0ABY4 charge swissprot:FLAW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLAW_ECOLI eggNOG COG0716 http://eggnogapi.embl.de/nog_data/html/tree/COG0716 eggNOG ENOG41071R3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41071R3 epestfind swissprot:FLAW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLAW_ECOLI garnier swissprot:FLAW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLAW_ECOLI helixturnhelix swissprot:FLAW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLAW_ECOLI hmoment swissprot:FLAW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLAW_ECOLI iep swissprot:FLAW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLAW_ECOLI inforesidue swissprot:FLAW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLAW_ECOLI octanol swissprot:FLAW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLAW_ECOLI pepcoil swissprot:FLAW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLAW_ECOLI pepdigest swissprot:FLAW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLAW_ECOLI pepinfo swissprot:FLAW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLAW_ECOLI pepnet swissprot:FLAW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLAW_ECOLI pepstats swissprot:FLAW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLAW_ECOLI pepwheel swissprot:FLAW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLAW_ECOLI pepwindow swissprot:FLAW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLAW_ECOLI sigcleave swissprot:FLAW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLAW_ECOLI ## Database ID URL or Descriptions # AltName Acetyl-CoA acetoacetate-CoA transferase subunit alpha # BRENDA 2.8.3 2026 # BioGrid 4259179 16 # CATALYTIC ACTIVITY ATOD_ECOLI Acyl-CoA + acetate = a fatty acid anion + acetyl-CoA. # EcoGene EG11669 atoD # GO_function GO:0008775 acetate CoA-transferase activity; IEA:UniProtKB-EC. # GO_process GO:0046459 short-chain fatty acid metabolic process; IEA:UniProtKB-UniPathway. # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0044281 small molecule metabolic process # IntAct P76458 3 # InterPro IPR004163 CoA_transf_BS # InterPro IPR004165 CoA_trans_fam_I # InterPro IPR012792 3-oxoacid_CoA-transf_A # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00627 Aminobenzoate degradation # KEGG_Pathway ko00640 Propanoate metabolism # KEGG_Pathway ko00650 Butanoate metabolism # KEGG_Pathway ko02020 Two-component system # Organism ATOD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR13707 PTHR13707 # PATHWAY ATOD_ECOLI Lipid metabolism; short-chain fatty acid metabolism. # PATRIC 32119801 VBIEscCol129921_2310 # PDB 1K6D X-ray; 1.90 A; A/B=1-220 # PDB 5DBN X-ray; 2.55 A; A/C/E/G=1-220 # PIR C64992 C64992 # PROSITE PS01273 COA_TRANSF_1 # Pfam PF01144 CoA_trans # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ATOD_ECOLI Acetate CoA-transferase subunit alpha # RefSeq NP_416725 NC_000913.3 # RefSeq WP_000850540 NZ_LN832404.1 # SIMILARITY Belongs to the 3-oxoacid CoA-transferase subunit A family. {ECO 0000305}. # SMART SM00882 CoA_trans # SUBUNIT Heterodimer. {ECO 0000250}. # TIGRFAMs TIGR02429 pcaI_scoA_fam # eggNOG COG1788 LUCA # eggNOG ENOG4107QP7 Bacteria BLAST swissprot:ATOD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ATOD_ECOLI BioCyc ECOL316407:JW2215-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2215-MONOMER BioCyc EcoCyc:ATOD-MONOMER http://biocyc.org/getid?id=EcoCyc:ATOD-MONOMER BioCyc MetaCyc:ATOD-MONOMER http://biocyc.org/getid?id=MetaCyc:ATOD-MONOMER COG COG1788 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1788 DIP DIP-9191N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9191N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.8.3.8 http://www.genome.jp/dbget-bin/www_bget?EC:2.8.3.8 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.8.3.8 http://enzyme.expasy.org/EC/2.8.3.8 EchoBASE EB1620 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1620 EcoGene EG11669 http://www.ecogene.org/geneInfo.php?eg_id=EG11669 EnsemblBacteria AAC75281 http://www.ensemblgenomes.org/id/AAC75281 EnsemblBacteria AAC75281 http://www.ensemblgenomes.org/id/AAC75281 EnsemblBacteria BAA16017 http://www.ensemblgenomes.org/id/BAA16017 EnsemblBacteria BAA16017 http://www.ensemblgenomes.org/id/BAA16017 EnsemblBacteria BAA16017 http://www.ensemblgenomes.org/id/BAA16017 EnsemblBacteria b2221 http://www.ensemblgenomes.org/id/b2221 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008775 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008775 GO_process GO:0046459 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046459 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 947525 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947525 HOGENOM HOG000221244 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000221244&db=HOGENOM6 InParanoid P76458 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76458 IntAct P76458 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76458* IntEnz 2.8.3.8 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.8.3.8 InterPro IPR004163 http://www.ebi.ac.uk/interpro/entry/IPR004163 InterPro IPR004165 http://www.ebi.ac.uk/interpro/entry/IPR004165 InterPro IPR012792 http://www.ebi.ac.uk/interpro/entry/IPR012792 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2215 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2215 KEGG_Gene eco:b2221 http://www.genome.jp/dbget-bin/www_bget?eco:b2221 KEGG_Orthology KO:K01034 http://www.genome.jp/dbget-bin/www_bget?KO:K01034 KEGG_Pathway ko00627 http://www.genome.jp/kegg-bin/show_pathway?ko00627 KEGG_Pathway ko00640 http://www.genome.jp/kegg-bin/show_pathway?ko00640 KEGG_Pathway ko00650 http://www.genome.jp/kegg-bin/show_pathway?ko00650 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 KEGG_Reaction rn:R01179 http://www.genome.jp/dbget-bin/www_bget?rn:R01179 KEGG_Reaction rn:R01359 http://www.genome.jp/dbget-bin/www_bget?rn:R01359 KEGG_Reaction rn:R07832 http://www.genome.jp/dbget-bin/www_bget?rn:R07832 MINT MINT-1293580 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1293580 OMA VKAHRAD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VKAHRAD PANTHER PTHR13707 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13707 PDB 1K6D http://www.ebi.ac.uk/pdbe-srv/view/entry/1K6D PDB 5DBN http://www.ebi.ac.uk/pdbe-srv/view/entry/5DBN PDBsum 1K6D http://www.ebi.ac.uk/pdbsum/1K6D PDBsum 5DBN http://www.ebi.ac.uk/pdbsum/5DBN PROSITE PS01273 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01273 PSORT swissprot:ATOD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ATOD_ECOLI PSORT-B swissprot:ATOD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ATOD_ECOLI PSORT2 swissprot:ATOD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ATOD_ECOLI Pfam PF01144 http://pfam.xfam.org/family/PF01144 Phobius swissprot:ATOD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ATOD_ECOLI PhylomeDB P76458 http://phylomedb.org/?seqid=P76458 ProteinModelPortal P76458 http://www.proteinmodelportal.org/query/uniprot/P76458 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416725 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416725 RefSeq WP_000850540 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000850540 SMART SM00882 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00882 SMR P76458 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76458 STRING 511145.b2221 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2221&targetmode=cogs STRING COG1788 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1788&targetmode=cogs TIGRFAMs TIGR02429 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02429 UniProtKB ATOD_ECOLI http://www.uniprot.org/uniprot/ATOD_ECOLI UniProtKB-AC P76458 http://www.uniprot.org/uniprot/P76458 charge swissprot:ATOD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ATOD_ECOLI eggNOG COG1788 http://eggnogapi.embl.de/nog_data/html/tree/COG1788 eggNOG ENOG4107QP7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QP7 epestfind swissprot:ATOD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ATOD_ECOLI garnier swissprot:ATOD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ATOD_ECOLI helixturnhelix swissprot:ATOD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ATOD_ECOLI hmoment swissprot:ATOD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ATOD_ECOLI iep swissprot:ATOD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ATOD_ECOLI inforesidue swissprot:ATOD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ATOD_ECOLI octanol swissprot:ATOD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ATOD_ECOLI pepcoil swissprot:ATOD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ATOD_ECOLI pepdigest swissprot:ATOD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ATOD_ECOLI pepinfo swissprot:ATOD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ATOD_ECOLI pepnet swissprot:ATOD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ATOD_ECOLI pepstats swissprot:ATOD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ATOD_ECOLI pepwheel swissprot:ATOD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ATOD_ECOLI pepwindow swissprot:ATOD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ATOD_ECOLI sigcleave swissprot:ATOD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ATOD_ECOLI ## Database ID URL or Descriptions # BioGrid 4261530 121 # CDD cd06174 MFS # EcoGene EG14063 yegT # FUNCTION YEGT_ECOLI Could be involved in nucleoside transport. {ECO 0000250}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005337 nucleoside transmembrane transporter activity; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # InterPro IPR004740 Nuc_H_symport # InterPro IPR020846 MFS_dom # Organism YEGT_ECOLI Escherichia coli (strain K12) # PATRIC 32119529 VBIEscCol129921_2175 # PIR A64977 A64977 # PROSITE PS50850 MFS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEGT_ECOLI Putative nucleoside transporter YegT # RefSeq NP_416601 NC_000913.3 # RefSeq WP_000858484 NZ_LN832404.1 # SIMILARITY Belongs to the major facilitator superfamily. Nucleoside:H(+) symporter (NHS) (TC 2.A.1.10) family. {ECO 0000305}. # SUBCELLULAR LOCATION YEGT_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.10 the major facilitator superfamily (mfs) # TIGRFAMs TIGR00889 2A0110 # eggNOG ENOG4105EAA Bacteria # eggNOG ENOG410ZVFU LUCA BLAST swissprot:YEGT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEGT_ECOLI BioCyc ECOL316407:JW2085-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2085-MONOMER BioCyc EcoCyc:B2098-MONOMER http://biocyc.org/getid?id=EcoCyc:B2098-MONOMER DIP DIP-11890N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11890N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3816 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3816 EcoGene EG14063 http://www.ecogene.org/geneInfo.php?eg_id=EG14063 EnsemblBacteria AAC75159 http://www.ensemblgenomes.org/id/AAC75159 EnsemblBacteria AAC75159 http://www.ensemblgenomes.org/id/AAC75159 EnsemblBacteria BAA15967 http://www.ensemblgenomes.org/id/BAA15967 EnsemblBacteria BAA15967 http://www.ensemblgenomes.org/id/BAA15967 EnsemblBacteria BAA15967 http://www.ensemblgenomes.org/id/BAA15967 EnsemblBacteria b2098 http://www.ensemblgenomes.org/id/b2098 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005337 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005337 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GeneID 946638 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946638 HOGENOM HOG000026502 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000026502&db=HOGENOM6 InParanoid P76417 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76417 IntAct P76417 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76417* InterPro IPR004740 http://www.ebi.ac.uk/interpro/entry/IPR004740 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Gene ecj:JW2085 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2085 KEGG_Gene eco:b2098 http://www.genome.jp/dbget-bin/www_bget?eco:b2098 MINT MINT-1263598 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1263598 OMA YDFFFVS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YDFFFVS PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:YEGT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEGT_ECOLI PSORT-B swissprot:YEGT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEGT_ECOLI PSORT2 swissprot:YEGT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEGT_ECOLI Phobius swissprot:YEGT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEGT_ECOLI PhylomeDB P76417 http://phylomedb.org/?seqid=P76417 ProteinModelPortal P76417 http://www.proteinmodelportal.org/query/uniprot/P76417 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416601 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416601 RefSeq WP_000858484 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000858484 STRING 511145.b2098 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2098&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.10 http://www.tcdb.org/search/result.php?tc=2.A.1.10 TIGRFAMs TIGR00889 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00889 UniProtKB YEGT_ECOLI http://www.uniprot.org/uniprot/YEGT_ECOLI UniProtKB-AC P76417 http://www.uniprot.org/uniprot/P76417 charge swissprot:YEGT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEGT_ECOLI eggNOG ENOG4105EAA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EAA eggNOG ENOG410ZVFU http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZVFU epestfind swissprot:YEGT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEGT_ECOLI garnier swissprot:YEGT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEGT_ECOLI helixturnhelix swissprot:YEGT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEGT_ECOLI hmoment swissprot:YEGT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEGT_ECOLI iep swissprot:YEGT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEGT_ECOLI inforesidue swissprot:YEGT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEGT_ECOLI octanol swissprot:YEGT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEGT_ECOLI pepcoil swissprot:YEGT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEGT_ECOLI pepdigest swissprot:YEGT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEGT_ECOLI pepinfo swissprot:YEGT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEGT_ECOLI pepnet swissprot:YEGT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEGT_ECOLI pepstats swissprot:YEGT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEGT_ECOLI pepwheel swissprot:YEGT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEGT_ECOLI pepwindow swissprot:YEGT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEGT_ECOLI sigcleave swissprot:YEGT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEGT_ECOLI ## Database ID URL or Descriptions # Organism YUAU_ECOLI Escherichia coli (strain K12) # RecName YUAU_ECOLI Uncharacterized protein YuaU # RefSeq NP_061414 NC_002483.1 # RefSeq WP_000990665 NZ_CP014273.1 BLAST swissprot:YUAU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YUAU_ECOLI EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1263508 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263508 OMA QHQIFPR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QHQIFPR PSORT swissprot:YUAU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YUAU_ECOLI PSORT-B swissprot:YUAU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YUAU_ECOLI PSORT2 swissprot:YUAU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YUAU_ECOLI Phobius swissprot:YUAU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YUAU_ECOLI ProteinModelPortal Q9JMS0 http://www.proteinmodelportal.org/query/uniprot/Q9JMS0 RefSeq NP_061414 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061414 RefSeq WP_000990665 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000990665 UniProtKB YUAU_ECOLI http://www.uniprot.org/uniprot/YUAU_ECOLI UniProtKB-AC Q9JMS0 http://www.uniprot.org/uniprot/Q9JMS0 charge swissprot:YUAU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YUAU_ECOLI epestfind swissprot:YUAU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YUAU_ECOLI garnier swissprot:YUAU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YUAU_ECOLI helixturnhelix swissprot:YUAU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YUAU_ECOLI hmoment swissprot:YUAU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YUAU_ECOLI iep swissprot:YUAU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YUAU_ECOLI inforesidue swissprot:YUAU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YUAU_ECOLI octanol swissprot:YUAU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YUAU_ECOLI pepcoil swissprot:YUAU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YUAU_ECOLI pepdigest swissprot:YUAU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YUAU_ECOLI pepinfo swissprot:YUAU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YUAU_ECOLI pepnet swissprot:YUAU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YUAU_ECOLI pepstats swissprot:YUAU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YUAU_ECOLI pepwheel swissprot:YUAU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YUAU_ECOLI pepwindow swissprot:YUAU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YUAU_ECOLI sigcleave swissprot:YUAU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YUAU_ECOLI ## Database ID URL or Descriptions # AltName MIND_ECOLI Cell division inhibitor MinD # BioGrid 4262868 668 # DISRUPTION PHENOTYPE In a minCDE operon disruption (minC-minD- minE), cells divide not only at midpoint but also at their poles, yielding small minicells and long rods. Loss of polar localization of several polar-localized proteins including GroEL-GroES, TnaA and YqjD. {ECO:0000269|PubMed 22380631}. # EcoGene EG10597 minD # FUNCTION MIND_ECOLI ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. {ECO 0000269|PubMed 1836760, ECO 0000269|PubMed 22380631}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0009898 cytoplasmic side of plasma membrane; IDA:EcoCyc. # GO_component GO:0031226 intrinsic component of plasma membrane; IDA:EcoCyc. # GO_component GO:0060187 cell pole; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IDA:EcoCyc. # GO_function GO:0016887 ATPase activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0007049 cell cycle; IEA:UniProtKB-KW. # GO_process GO:0007059 chromosome segregation; IMP:EcoCyc. # GO_process GO:0051301 cell division; IDA:EcoCyc. # GO_process GO:0051782 negative regulation of cell division; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0007049 cell cycle # GOslim_process GO:0007059 chromosome segregation # GOslim_process GO:0008150 biological_process # GOslim_process GO:0051301 cell division # Gene3D 3.40.50.300 -; 1. # INTERACTION MIND_ECOLI P18196 minC; NbExp=6; IntAct=EBI-554545, EBI-554060; P0A734 minE; NbExp=4; IntAct=EBI-554545, EBI-1118020; # IntAct P0AEZ3 13 # InterPro IPR002586 CobQ/CobB/MinD/ParA_Nub-bd_dom # InterPro IPR010223 MinD_bac-type # InterPro IPR025501 MinD # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko03036 Chromosome # KEGG_Brite ko04812 Cytoskeleton proteins # Organism MIND_ECOLI Escherichia coli (strain K12) # PATRIC 32117594 VBIEscCol129921_1219 # PDB 3Q9L X-ray; 2.34 A; A/B=1-260 # PDB 3R9I X-ray; 2.60 A; A/B/C/D=1-260 # PDB 3R9J X-ray; 4.30 A; A/B=1-260 # PIR B31877 CCECID # PIRSF PIRSF003092 MinD # Pfam PF01656 CbiA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MIND_ECOLI Septum site-determining protein MinD # RefSeq NP_415693 NC_000913.3 # RefSeq WP_000101055 NZ_LN832404.1 # SIMILARITY Belongs to the ParA family. MinD subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION MIND_ECOLI Cell inner membrane; Peripheral membrane protein. # SUBUNIT MIND_ECOLI Interacts with MinC and FtsZ. # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR01968 minD_bact # eggNOG COG2894 LUCA # eggNOG ENOG4107QMS Bacteria BLAST swissprot:MIND_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MIND_ECOLI BioCyc ECOL316407:JW1164-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1164-MONOMER BioCyc EcoCyc:EG10597-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10597-MONOMER COG COG2894 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2894 DIP DIP-35946N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35946N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1016/0092-8674(89)90586-2 http://dx.doi.org/10.1016/0092-8674(89)90586-2 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.96.9.4971 http://dx.doi.org/10.1073/pnas.96.9.4971 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.2012.08021.x http://dx.doi.org/10.1111/j.1365-2958.2012.08021.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J03153 http://www.ebi.ac.uk/ena/data/view/J03153 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0592 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0592 EcoGene EG10597 http://www.ecogene.org/geneInfo.php?eg_id=EG10597 EnsemblBacteria AAC74259 http://www.ensemblgenomes.org/id/AAC74259 EnsemblBacteria AAC74259 http://www.ensemblgenomes.org/id/AAC74259 EnsemblBacteria BAA36009 http://www.ensemblgenomes.org/id/BAA36009 EnsemblBacteria BAA36009 http://www.ensemblgenomes.org/id/BAA36009 EnsemblBacteria BAA36009 http://www.ensemblgenomes.org/id/BAA36009 EnsemblBacteria b1175 http://www.ensemblgenomes.org/id/b1175 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0009898 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009898 GO_component GO:0031226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031226 GO_component GO:0060187 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060187 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GO_process GO:0007059 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007059 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GO_process GO:0051782 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051782 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GOslim_process GO:0007059 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007059 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945741 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945741 HOGENOM HOG000019419 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000019419&db=HOGENOM6 InParanoid P0AEZ3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEZ3 IntAct P0AEZ3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEZ3* InterPro IPR002586 http://www.ebi.ac.uk/interpro/entry/IPR002586 InterPro IPR010223 http://www.ebi.ac.uk/interpro/entry/IPR010223 InterPro IPR025501 http://www.ebi.ac.uk/interpro/entry/IPR025501 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Brite ko04812 http://www.genome.jp/dbget-bin/www_bget?ko04812 KEGG_Gene ecj:JW1164 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1164 KEGG_Gene eco:b1175 http://www.genome.jp/dbget-bin/www_bget?eco:b1175 KEGG_Orthology KO:K03609 http://www.genome.jp/dbget-bin/www_bget?KO:K03609 OMA NRVRPKM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NRVRPKM PDB 3Q9L http://www.ebi.ac.uk/pdbe-srv/view/entry/3Q9L PDB 3R9I http://www.ebi.ac.uk/pdbe-srv/view/entry/3R9I PDB 3R9J http://www.ebi.ac.uk/pdbe-srv/view/entry/3R9J PDBsum 3Q9L http://www.ebi.ac.uk/pdbsum/3Q9L PDBsum 3R9I http://www.ebi.ac.uk/pdbsum/3R9I PDBsum 3R9J http://www.ebi.ac.uk/pdbsum/3R9J PSORT swissprot:MIND_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MIND_ECOLI PSORT-B swissprot:MIND_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MIND_ECOLI PSORT2 swissprot:MIND_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MIND_ECOLI Pfam PF01656 http://pfam.xfam.org/family/PF01656 Phobius swissprot:MIND_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MIND_ECOLI PhylomeDB P0AEZ3 http://phylomedb.org/?seqid=P0AEZ3 ProteinModelPortal P0AEZ3 http://www.proteinmodelportal.org/query/uniprot/P0AEZ3 PubMed 10220403 http://www.ncbi.nlm.nih.gov/pubmed/10220403 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1836760 http://www.ncbi.nlm.nih.gov/pubmed/1836760 PubMed 22380631 http://www.ncbi.nlm.nih.gov/pubmed/22380631 PubMed 2645057 http://www.ncbi.nlm.nih.gov/pubmed/2645057 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_415693 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415693 RefSeq WP_000101055 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000101055 SMR P0AEZ3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEZ3 STRING 511145.b1175 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1175&targetmode=cogs STRING COG2894 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2894&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SWISS-2DPAGE P0AEZ3 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AEZ3 TIGRFAMs TIGR01968 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01968 UniProtKB MIND_ECOLI http://www.uniprot.org/uniprot/MIND_ECOLI UniProtKB-AC P0AEZ3 http://www.uniprot.org/uniprot/P0AEZ3 charge swissprot:MIND_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MIND_ECOLI eggNOG COG2894 http://eggnogapi.embl.de/nog_data/html/tree/COG2894 eggNOG ENOG4107QMS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QMS epestfind swissprot:MIND_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MIND_ECOLI garnier swissprot:MIND_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MIND_ECOLI helixturnhelix swissprot:MIND_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MIND_ECOLI hmoment swissprot:MIND_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MIND_ECOLI iep swissprot:MIND_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MIND_ECOLI inforesidue swissprot:MIND_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MIND_ECOLI octanol swissprot:MIND_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MIND_ECOLI pepcoil swissprot:MIND_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MIND_ECOLI pepdigest swissprot:MIND_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MIND_ECOLI pepinfo swissprot:MIND_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MIND_ECOLI pepnet swissprot:MIND_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MIND_ECOLI pepstats swissprot:MIND_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MIND_ECOLI pepwheel swissprot:MIND_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MIND_ECOLI pepwindow swissprot:MIND_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MIND_ECOLI sigcleave swissprot:MIND_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MIND_ECOLI ## Database ID URL or Descriptions # BioGrid 4261233 11 # CDD cd00429 RPE # COFACTOR ALSE_ECOLI Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000269|PubMed 18700786}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 18700786}; Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 18700786}; Note=Binds 1 divalent metal cation per subunit. Activity is highest with Co(2+) > Mn(2+) > Zn(2+). {ECO 0000269|PubMed 18700786}; # EcoGene EG11957 alsE # FUNCTION ALSE_ECOLI Catalyzes the reversible epimerization of D-allulose 6- phosphate to D-fructose 6-phosphate. Can also catalyze with lower efficiency the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate. {ECO 0000269|PubMed 18700786, ECO 0000269|PubMed 9401019}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0004750 ribulose-phosphate 3-epimerase activity; IBA:GO_Central. # GO_function GO:0034700 allulose 6-phosphate 3-epimerase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IDA:UniProtKB. # GO_process GO:0009052 pentose-phosphate shunt, non-oxidative branch; IBA:GO_Central. # GO_process GO:0019316 D-allose catabolic process; IMP:EcoCyc. # GO_process GO:0019323 pentose catabolic process; IBA:GO_Central. # GO_process GO:0044262 cellular carbohydrate metabolic process; IDA:UniProtKB. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.70 -; 1. # IntAct P32719 2 # InterPro IPR000056 Ribul_P_3_epim-like # InterPro IPR011060 RibuloseP-bd_barrel # InterPro IPR013785 Aldolase_TIM # Organism ALSE_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11749 PTHR11749 # PATHWAY ALSE_ECOLI Carbohydrate degradation; D-allose degradation. # PATRIC 32123725 VBIEscCol129921_4211 # PDB 3CT7 X-ray; 2.50 A; A/B/C/D/E/F=1-231 # PDB 3CTL X-ray; 2.20 A; A/B/C/D/E/F=1-231 # PIR D65217 D65217 # PROSITE PS01085 RIBUL_P_3_EPIMER_1 # PROSITE PS01086 RIBUL_P_3_EPIMER_2 # Pfam PF00834 Ribul_P_3_epim # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ALSE_ECOLI D-allulose-6-phosphate 3-epimerase # RefSeq NP_418509 NC_000913.3 # RefSeq WP_001311314 NZ_LN832404.1 # SIMILARITY Belongs to the ribulose-phosphate 3-epimerase family. {ECO 0000305}. # SUBUNIT Homohexamer. Trimer of dimers. {ECO:0000269|PubMed 18700786}. # SUPFAM SSF51366 SSF51366 # eggNOG COG0036 LUCA # eggNOG ENOG4105UP7 Bacteria BLAST swissprot:ALSE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ALSE_ECOLI BioCyc ECOL316407:JW4046-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4046-MONOMER BioCyc EcoCyc:EG11957-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11957-MONOMER BioCyc MetaCyc:EG11957-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11957-MONOMER DOI 10.1021/bi800821v http://dx.doi.org/10.1021/bi800821v DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.1.3.- http://www.genome.jp/dbget-bin/www_bget?EC:5.1.3.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 5.1.3.- http://enzyme.expasy.org/EC/5.1.3.- EchoBASE EB1900 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1900 EcoGene EG11957 http://www.ecogene.org/geneInfo.php?eg_id=EG11957 EnsemblBacteria AAC77046 http://www.ensemblgenomes.org/id/AAC77046 EnsemblBacteria AAC77046 http://www.ensemblgenomes.org/id/AAC77046 EnsemblBacteria BAE78088 http://www.ensemblgenomes.org/id/BAE78088 EnsemblBacteria BAE78088 http://www.ensemblgenomes.org/id/BAE78088 EnsemblBacteria BAE78088 http://www.ensemblgenomes.org/id/BAE78088 EnsemblBacteria b4085 http://www.ensemblgenomes.org/id/b4085 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004750 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004750 GO_function GO:0034700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034700 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0009052 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009052 GO_process GO:0019316 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019316 GO_process GO:0019323 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019323 GO_process GO:0044262 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044262 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 948595 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948595 HOGENOM HOG000259348 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000259348&db=HOGENOM6 InParanoid P32719 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32719 IntAct P32719 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32719* IntEnz 5.1.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.1.3 InterPro IPR000056 http://www.ebi.ac.uk/interpro/entry/IPR000056 InterPro IPR011060 http://www.ebi.ac.uk/interpro/entry/IPR011060 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 KEGG_Gene ecj:JW4046 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4046 KEGG_Gene eco:b4085 http://www.genome.jp/dbget-bin/www_bget?eco:b4085 OMA PQDYISQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PQDYISQ PANTHER PTHR11749 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11749 PDB 3CT7 http://www.ebi.ac.uk/pdbe-srv/view/entry/3CT7 PDB 3CTL http://www.ebi.ac.uk/pdbe-srv/view/entry/3CTL PDBsum 3CT7 http://www.ebi.ac.uk/pdbsum/3CT7 PDBsum 3CTL http://www.ebi.ac.uk/pdbsum/3CTL PROSITE PS01085 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01085 PROSITE PS01086 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01086 PSORT swissprot:ALSE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ALSE_ECOLI PSORT-B swissprot:ALSE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ALSE_ECOLI PSORT2 swissprot:ALSE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ALSE_ECOLI Pfam PF00834 http://pfam.xfam.org/family/PF00834 Phobius swissprot:ALSE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ALSE_ECOLI PhylomeDB P32719 http://phylomedb.org/?seqid=P32719 ProteinModelPortal P32719 http://www.proteinmodelportal.org/query/uniprot/P32719 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18700786 http://www.ncbi.nlm.nih.gov/pubmed/18700786 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9401019 http://www.ncbi.nlm.nih.gov/pubmed/9401019 RefSeq NP_418509 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418509 RefSeq WP_001311314 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001311314 SMR P32719 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32719 STRING 511145.b4085 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4085&targetmode=cogs SUPFAM SSF51366 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51366 UniProtKB ALSE_ECOLI http://www.uniprot.org/uniprot/ALSE_ECOLI UniProtKB-AC P32719 http://www.uniprot.org/uniprot/P32719 charge swissprot:ALSE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ALSE_ECOLI eggNOG COG0036 http://eggnogapi.embl.de/nog_data/html/tree/COG0036 eggNOG ENOG4105UP7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105UP7 epestfind swissprot:ALSE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ALSE_ECOLI garnier swissprot:ALSE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ALSE_ECOLI helixturnhelix swissprot:ALSE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ALSE_ECOLI hmoment swissprot:ALSE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ALSE_ECOLI iep swissprot:ALSE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ALSE_ECOLI inforesidue swissprot:ALSE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ALSE_ECOLI octanol swissprot:ALSE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ALSE_ECOLI pepcoil swissprot:ALSE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ALSE_ECOLI pepdigest swissprot:ALSE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ALSE_ECOLI pepinfo swissprot:ALSE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ALSE_ECOLI pepnet swissprot:ALSE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ALSE_ECOLI pepstats swissprot:ALSE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ALSE_ECOLI pepwheel swissprot:ALSE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ALSE_ECOLI pepwindow swissprot:ALSE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ALSE_ECOLI sigcleave swissprot:ALSE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ALSE_ECOLI ## Database ID URL or Descriptions # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG12547 yjhE # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR020846 MFS_dom # InterPro IPR024671 Atg22-like # Organism YJHE_ECOLI Escherichia coli (strain K12) # PIR S56507 S56507 # PROSITE PS50850 MFS # Pfam PF11700 ATG22 # Proteomes UP000000625 Chromosome # RecName YJHE_ECOLI Putative uncharacterized protein YjhE # SEQUENCE CAUTION Sequence=AAA97178.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SUBCELLULAR LOCATION YJHE_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # SUPFAM SSF103473 SSF103473 BLAST swissprot:YJHE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJHE_ECOLI BioCyc EcoCyc:G7903-MONOMER http://biocyc.org/getid?id=EcoCyc:G7903-MONOMER DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2435 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2435 EcoGene EG12547 http://www.ecogene.org/geneInfo.php?eg_id=EG12547 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 InParanoid P39355 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39355 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 InterPro IPR024671 http://www.ebi.ac.uk/interpro/entry/IPR024671 PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:YJHE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJHE_ECOLI PSORT-B swissprot:YJHE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJHE_ECOLI PSORT2 swissprot:YJHE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJHE_ECOLI Pfam PF11700 http://pfam.xfam.org/family/PF11700 Phobius swissprot:YJHE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJHE_ECOLI ProteinModelPortal P39355 http://www.proteinmodelportal.org/query/uniprot/P39355 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 UniProtKB YJHE_ECOLI http://www.uniprot.org/uniprot/YJHE_ECOLI UniProtKB-AC P39355 http://www.uniprot.org/uniprot/P39355 charge swissprot:YJHE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJHE_ECOLI epestfind swissprot:YJHE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJHE_ECOLI garnier swissprot:YJHE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJHE_ECOLI helixturnhelix swissprot:YJHE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJHE_ECOLI hmoment swissprot:YJHE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJHE_ECOLI iep swissprot:YJHE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJHE_ECOLI inforesidue swissprot:YJHE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJHE_ECOLI octanol swissprot:YJHE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJHE_ECOLI pepcoil swissprot:YJHE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJHE_ECOLI pepdigest swissprot:YJHE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJHE_ECOLI pepinfo swissprot:YJHE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJHE_ECOLI pepnet swissprot:YJHE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJHE_ECOLI pepstats swissprot:YJHE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJHE_ECOLI pepwheel swissprot:YJHE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJHE_ECOLI pepwindow swissprot:YJHE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJHE_ECOLI sigcleave swissprot:YJHE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJHE_ECOLI ## Database ID URL or Descriptions # BRENDA 2.4.1 2026 # BioGrid 4259324 9 # CATALYTIC ACTIVITY PHSM_ECOLI ((1->4)-alpha-D-glucosyl)(n) + phosphate = ((1->4)-alpha-D-glucosyl)(n-1) + alpha-D-glucose 1-phosphate. # CAZy GT35 Glycosyltransferase Family 35 # CDD cd04300 GT1_Glycogen_Phosphorylase # COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI 597326; # EcoGene EG10560 malP # FUNCTION PHSM_ECOLI Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008184 glycogen phosphorylase activity; IBA:GO_Central. # GO_function GO:0030170 pyridoxal phosphate binding; IDA:EcoCyc. # GO_function GO:0031220 maltodextrin phosphorylase activity; IDA:EcoliWiki. # GO_process GO:0005980 glycogen catabolic process; IDA:EcoliWiki. # GO_process GO:0030980 alpha-glucan catabolic process; IDA:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0009056 catabolic process # IntAct P00490 26 # InterPro IPR000811 Glyco_trans_35 # InterPro IPR011833 Glycg_phsphrylas # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00500 Starch and sucrose metabolism # KEGG_Pathway ko04910 Insulin signaling pathway # Organism PHSM_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11468 PTHR11468 # PATRIC 32122272 VBIEscCol129921_3513 # PDB 1AHP X-ray; 3.00 A; A/B=1-795 # PDB 1E4O X-ray; 2.90 A; A/B=2-797 # PDB 1L5V X-ray; 2.00 A; A/B=2-797 # PDB 1L5W X-ray; 1.80 A; A/B=2-797 # PDB 1L6I X-ray; 2.20 A; A/B=2-797 # PDB 1QM5 X-ray; 2.00 A; A/B=2-797 # PDB 2ASV X-ray; 1.95 A; A/B=2-797 # PDB 2AV6 X-ray; 2.01 A; A/B=2-797 # PDB 2AW3 X-ray; 2.20 A; A/B=2-797 # PDB 2AZD X-ray; 2.16 A; A/B=2-797 # PDB 2ECP X-ray; 2.95 A; A/B=2-795 # PIR D65137 PHECGM # PIRSF PIRSF000460 Pprylas_GlgP # PROSITE PS00102 PHOSPHORYLASE # Pfam PF00343 Phosphorylase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PHSM_ECOLI Maltodextrin phosphorylase # RefSeq WP_000081909 NZ_LN832404.1 # RefSeq YP_026218 NC_000913.3 # SIMILARITY Belongs to the glycogen phosphorylase family. {ECO 0000305}. # SUBUNIT PHSM_ECOLI Homodimer. # TIGRFAMs TIGR02093 P_ylase # eggNOG COG0058 LUCA # eggNOG ENOG4107QQN Bacteria BLAST swissprot:PHSM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PHSM_ECOLI BioCyc ECOL316407:JW5689-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5689-MONOMER BioCyc EcoCyc:MALDEXPHOSPHORYL-MONOMER http://biocyc.org/getid?id=EcoCyc:MALDEXPHOSPHORYL-MONOMER BioCyc MetaCyc:MALDEXPHOSPHORYL-MONOMER http://biocyc.org/getid?id=MetaCyc:MALDEXPHOSPHORYL-MONOMER COG COG0058 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0058 DIP DIP-10146N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10146N DOI 10.1007/BF00333795 http://dx.doi.org/10.1007/BF00333795 DOI 10.1016/0014-5793(80)81311-1 http://dx.doi.org/10.1016/0014-5793(80)81311-1 DOI 10.1016/0022-2836(83)90065-7 http://dx.doi.org/10.1016/0022-2836(83)90065-7 DOI 10.1021/bi9828573 http://dx.doi.org/10.1021/bi9828573 DOI 10.1038/313500a0 http://dx.doi.org/10.1038/313500a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/emboj/16.1.1 http://dx.doi.org/10.1093/emboj/16.1.1 DOI 10.1093/emboj/18.17.4619 http://dx.doi.org/10.1093/emboj/18.17.4619 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1111/j.1365-2958.1988.tb00053.x http://dx.doi.org/10.1111/j.1365-2958.1988.tb00053.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.4.1.1 http://www.genome.jp/dbget-bin/www_bget?EC:2.4.1.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M24342 http://www.ebi.ac.uk/ena/data/view/M24342 EMBL M32793 http://www.ebi.ac.uk/ena/data/view/M32793 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL V00304 http://www.ebi.ac.uk/ena/data/view/V00304 EMBL X02003 http://www.ebi.ac.uk/ena/data/view/X02003 EMBL X06791 http://www.ebi.ac.uk/ena/data/view/X06791 ENZYME 2.4.1.1 http://enzyme.expasy.org/EC/2.4.1.1 EchoBASE EB0555 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0555 EcoGene EG10560 http://www.ecogene.org/geneInfo.php?eg_id=EG10560 EnsemblBacteria AAT48180 http://www.ensemblgenomes.org/id/AAT48180 EnsemblBacteria AAT48180 http://www.ensemblgenomes.org/id/AAT48180 EnsemblBacteria BAE77874 http://www.ensemblgenomes.org/id/BAE77874 EnsemblBacteria BAE77874 http://www.ensemblgenomes.org/id/BAE77874 EnsemblBacteria BAE77874 http://www.ensemblgenomes.org/id/BAE77874 EnsemblBacteria b3417 http://www.ensemblgenomes.org/id/b3417 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008184 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008184 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_function GO:0031220 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031220 GO_process GO:0005980 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005980 GO_process GO:0030980 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030980 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GeneID 947922 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947922 HOGENOM HOG000278445 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278445&db=HOGENOM6 InParanoid P00490 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00490 IntAct P00490 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00490* IntEnz 2.4.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.1.1 InterPro IPR000811 http://www.ebi.ac.uk/interpro/entry/IPR000811 InterPro IPR011833 http://www.ebi.ac.uk/interpro/entry/IPR011833 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5689 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5689 KEGG_Gene eco:b3417 http://www.genome.jp/dbget-bin/www_bget?eco:b3417 KEGG_Orthology KO:K00688 http://www.genome.jp/dbget-bin/www_bget?KO:K00688 KEGG_Pathway ko00500 http://www.genome.jp/kegg-bin/show_pathway?ko00500 KEGG_Pathway ko04910 http://www.genome.jp/kegg-bin/show_pathway?ko04910 KEGG_Reaction rn:R02111 http://www.genome.jp/dbget-bin/www_bget?rn:R02111 MINT MINT-1225428 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1225428 OMA EYCERIW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EYCERIW PANTHER PTHR11468 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11468 PDB 1AHP http://www.ebi.ac.uk/pdbe-srv/view/entry/1AHP PDB 1E4O http://www.ebi.ac.uk/pdbe-srv/view/entry/1E4O PDB 1L5V http://www.ebi.ac.uk/pdbe-srv/view/entry/1L5V PDB 1L5W http://www.ebi.ac.uk/pdbe-srv/view/entry/1L5W PDB 1L6I http://www.ebi.ac.uk/pdbe-srv/view/entry/1L6I PDB 1QM5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1QM5 PDB 2ASV http://www.ebi.ac.uk/pdbe-srv/view/entry/2ASV PDB 2AV6 http://www.ebi.ac.uk/pdbe-srv/view/entry/2AV6 PDB 2AW3 http://www.ebi.ac.uk/pdbe-srv/view/entry/2AW3 PDB 2AZD http://www.ebi.ac.uk/pdbe-srv/view/entry/2AZD PDB 2ECP http://www.ebi.ac.uk/pdbe-srv/view/entry/2ECP PDBsum 1AHP http://www.ebi.ac.uk/pdbsum/1AHP PDBsum 1E4O http://www.ebi.ac.uk/pdbsum/1E4O PDBsum 1L5V http://www.ebi.ac.uk/pdbsum/1L5V PDBsum 1L5W http://www.ebi.ac.uk/pdbsum/1L5W PDBsum 1L6I http://www.ebi.ac.uk/pdbsum/1L6I PDBsum 1QM5 http://www.ebi.ac.uk/pdbsum/1QM5 PDBsum 2ASV http://www.ebi.ac.uk/pdbsum/2ASV PDBsum 2AV6 http://www.ebi.ac.uk/pdbsum/2AV6 PDBsum 2AW3 http://www.ebi.ac.uk/pdbsum/2AW3 PDBsum 2AZD http://www.ebi.ac.uk/pdbsum/2AZD PDBsum 2ECP http://www.ebi.ac.uk/pdbsum/2ECP PROSITE PS00102 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00102 PSORT swissprot:PHSM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PHSM_ECOLI PSORT-B swissprot:PHSM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PHSM_ECOLI PSORT2 swissprot:PHSM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PHSM_ECOLI Pfam PF00343 http://pfam.xfam.org/family/PF00343 Phobius swissprot:PHSM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PHSM_ECOLI PhylomeDB P00490 http://phylomedb.org/?seqid=P00490 ProteinModelPortal P00490 http://www.proteinmodelportal.org/query/uniprot/P00490 PubMed 10220320 http://www.ncbi.nlm.nih.gov/pubmed/10220320 PubMed 10469642 http://www.ncbi.nlm.nih.gov/pubmed/10469642 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 2845225 http://www.ncbi.nlm.nih.gov/pubmed/2845225 PubMed 3037809 http://www.ncbi.nlm.nih.gov/pubmed/3037809 PubMed 3155826 http://www.ncbi.nlm.nih.gov/pubmed/3155826 PubMed 6283313 http://www.ncbi.nlm.nih.gov/pubmed/6283313 PubMed 6339728 http://www.ncbi.nlm.nih.gov/pubmed/6339728 PubMed 6986282 http://www.ncbi.nlm.nih.gov/pubmed/6986282 PubMed 9009262 http://www.ncbi.nlm.nih.gov/pubmed/9009262 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000081909 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000081909 RefSeq YP_026218 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026218 SMR P00490 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00490 STRING 511145.b3417 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3417&targetmode=cogs STRING COG0058 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0058&targetmode=cogs TIGRFAMs TIGR02093 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02093 UniProtKB PHSM_ECOLI http://www.uniprot.org/uniprot/PHSM_ECOLI UniProtKB-AC P00490 http://www.uniprot.org/uniprot/P00490 charge swissprot:PHSM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PHSM_ECOLI eggNOG COG0058 http://eggnogapi.embl.de/nog_data/html/tree/COG0058 eggNOG ENOG4107QQN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QQN epestfind swissprot:PHSM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PHSM_ECOLI garnier swissprot:PHSM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PHSM_ECOLI helixturnhelix swissprot:PHSM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PHSM_ECOLI hmoment swissprot:PHSM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PHSM_ECOLI iep swissprot:PHSM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PHSM_ECOLI inforesidue swissprot:PHSM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PHSM_ECOLI octanol swissprot:PHSM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PHSM_ECOLI pepcoil swissprot:PHSM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PHSM_ECOLI pepdigest swissprot:PHSM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PHSM_ECOLI pepinfo swissprot:PHSM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PHSM_ECOLI pepnet swissprot:PHSM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PHSM_ECOLI pepstats swissprot:PHSM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PHSM_ECOLI pepwheel swissprot:PHSM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PHSM_ECOLI pepwindow swissprot:PHSM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PHSM_ECOLI sigcleave swissprot:PHSM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PHSM_ECOLI ## Database ID URL or Descriptions # BioGrid 4259443 7 # EcoGene EG12397 ycbF # FUNCTION YCBF_ECOLI Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of fimbriae. {ECO 0000269|PubMed 20345943}. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IEA:InterPro. # GO_process GO:0043711 pilus organization; IEA:InterPro. # GO_process GO:0061077 chaperone-mediated protein folding; IEA:InterPro. # GO_process GO:0071555 cell wall organization; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0006457 protein folding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 2.60.40.1070 -; 1. # Gene3D 2.60.40.360 -; 1. # INDUCTION Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression. {ECO:0000269|PubMed 20345943}. # InterPro IPR001829 Pili_assmbl_chaperone_bac # InterPro IPR008962 PapD-like # InterPro IPR016147 Pili_assmbl_chaperone_N # InterPro IPR016148 Pili_assmbl_chaperone_C # InterPro IPR018046 Pili_assmbl_chaperone_CS # MISCELLANEOUS The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed. {ECO:0000305|PubMed 20345943}. # Organism YCBF_ECOLI Escherichia coli (strain K12) # PATRIC 32117107 VBIEscCol129921_0978 # PIR G64834 G64834 # PRINTS PR00969 CHAPERONPILI # PROSITE PS00635 PILI_CHAPERONE # Pfam PF00345 PapD_N # Pfam PF02753 PapD_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCBF_ECOLI Uncharacterized fimbrial chaperone YcbF # RefSeq NP_415464 NC_000913.3 # RefSeq WP_001307699 NZ_LN832404.1 # SIMILARITY Belongs to the periplasmic pilus chaperone family. {ECO 0000305}. # SIMILARITY Contains 1 Ig-like (immunoglobulin-like) domain. {ECO 0000305}. # SUBCELLULAR LOCATION YCBF_ECOLI Periplasm {ECO 0000250}. # SUPFAM SSF49354 SSF49354 # SUPFAM SSF49584 SSF49584 # eggNOG COG3121 LUCA # eggNOG ENOG4106PH7 Bacteria BLAST swissprot:YCBF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCBF_ECOLI BioCyc ECOL316407:JW5124-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5124-MONOMER BioCyc EcoCyc:EG12397-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12397-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1111/j.1432-1033.1985.tb09068.x http://dx.doi.org/10.1111/j.1432-1033.1985.tb09068.x DOI 10.1111/j.1462-2920.2010.02202.x http://dx.doi.org/10.1111/j.1462-2920.2010.02202.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X02826 http://www.ebi.ac.uk/ena/data/view/X02826 EchoBASE EB2298 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2298 EcoGene EG12397 http://www.ecogene.org/geneInfo.php?eg_id=EG12397 EnsemblBacteria AAC74030 http://www.ensemblgenomes.org/id/AAC74030 EnsemblBacteria AAC74030 http://www.ensemblgenomes.org/id/AAC74030 EnsemblBacteria BAA35699 http://www.ensemblgenomes.org/id/BAA35699 EnsemblBacteria BAA35699 http://www.ensemblgenomes.org/id/BAA35699 EnsemblBacteria BAA35699 http://www.ensemblgenomes.org/id/BAA35699 EnsemblBacteria b0944 http://www.ensemblgenomes.org/id/b0944 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_process GO:0043711 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043711 GO_process GO:0061077 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061077 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 2.60.40.1070 http://www.cathdb.info/version/latest/superfamily/2.60.40.1070 Gene3D 2.60.40.360 http://www.cathdb.info/version/latest/superfamily/2.60.40.360 GeneID 945559 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945559 HOGENOM HOG000260152 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260152&db=HOGENOM6 InterPro IPR001829 http://www.ebi.ac.uk/interpro/entry/IPR001829 InterPro IPR008962 http://www.ebi.ac.uk/interpro/entry/IPR008962 InterPro IPR016147 http://www.ebi.ac.uk/interpro/entry/IPR016147 InterPro IPR016148 http://www.ebi.ac.uk/interpro/entry/IPR016148 InterPro IPR018046 http://www.ebi.ac.uk/interpro/entry/IPR018046 KEGG_Gene ecj:JW5124 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5124 KEGG_Gene eco:b0944 http://www.genome.jp/dbget-bin/www_bget?eco:b0944 OMA VSWRTIN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VSWRTIN PRINTS PR00969 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00969 PROSITE PS00635 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00635 PSORT swissprot:YCBF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCBF_ECOLI PSORT-B swissprot:YCBF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCBF_ECOLI PSORT2 swissprot:YCBF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCBF_ECOLI Pfam PF00345 http://pfam.xfam.org/family/PF00345 Pfam PF02753 http://pfam.xfam.org/family/PF02753 Phobius swissprot:YCBF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCBF_ECOLI PhylomeDB P40876 http://phylomedb.org/?seqid=P40876 ProteinModelPortal P40876 http://www.proteinmodelportal.org/query/uniprot/P40876 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20345943 http://www.ncbi.nlm.nih.gov/pubmed/20345943 PubMed 2992959 http://www.ncbi.nlm.nih.gov/pubmed/2992959 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415464 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415464 RefSeq WP_001307699 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001307699 STRING 511145.b0944 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0944&targetmode=cogs SUPFAM SSF49354 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49354 SUPFAM SSF49584 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49584 UniProtKB YCBF_ECOLI http://www.uniprot.org/uniprot/YCBF_ECOLI UniProtKB-AC P40876 http://www.uniprot.org/uniprot/P40876 charge swissprot:YCBF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCBF_ECOLI eggNOG COG3121 http://eggnogapi.embl.de/nog_data/html/tree/COG3121 eggNOG ENOG4106PH7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106PH7 epestfind swissprot:YCBF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCBF_ECOLI garnier swissprot:YCBF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCBF_ECOLI helixturnhelix swissprot:YCBF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCBF_ECOLI hmoment swissprot:YCBF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCBF_ECOLI iep swissprot:YCBF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCBF_ECOLI inforesidue swissprot:YCBF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCBF_ECOLI octanol swissprot:YCBF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCBF_ECOLI pepcoil swissprot:YCBF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCBF_ECOLI pepdigest swissprot:YCBF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCBF_ECOLI pepinfo swissprot:YCBF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCBF_ECOLI pepnet swissprot:YCBF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCBF_ECOLI pepstats swissprot:YCBF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCBF_ECOLI pepwheel swissprot:YCBF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCBF_ECOLI pepwindow swissprot:YCBF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCBF_ECOLI sigcleave swissprot:YCBF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCBF_ECOLI ## Database ID URL or Descriptions # BioGrid 4261065 121 # EcoGene EG12375 ycaI # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0030420 establishment of competence for transformation; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0008150 biological_process # Gene3D 3.60.15.10 -; 1. # InterPro IPR001279 Metallo-B-lactamas # InterPro IPR004477 ComEC_N # InterPro IPR004797 Competence_ComEC/Rec2 # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02044 M00429 Competence-related DNA transformation transporter # KEGG_Brite ko02044 Secretion system # Organism YCAI_ECOLI Escherichia coli (strain K12) # PATRIC 32117039 VBIEscCol129921_0944 # PIR H64830 H64830 # Pfam PF00753 Lactamase_B # Pfam PF03772 Competence # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCAI_ECOLI Uncharacterized protein YcaI # RefSeq NP_415433 NC_000913.3 # RefSeq WP_000705764 NZ_LN832404.1 # SIMILARITY To B.subtilis ComEC, N.gonorrhoeae ComA, and H.influenzae Rec2. {ECO 0000305}. # SMART SM00849 Lactamase_B # SUBCELLULAR LOCATION YCAI_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # SUPFAM SSF56281 SSF56281 # TIGRFAMs TIGR00360 ComEC_N-term # TIGRFAMs TIGR00361 ComEC_Rec2 # eggNOG COG0658 LUCA # eggNOG COG2333 LUCA # eggNOG ENOG4108EQH Bacteria BLAST swissprot:YCAI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCAI_ECOLI BioCyc ECOL316407:JW5120-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5120-MONOMER BioCyc EcoCyc:EG12375-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12375-MONOMER COG COG0658 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0658 COG COG2333 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2333 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1993.tb01098.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb01098.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL Z11796 http://www.ebi.ac.uk/ena/data/view/Z11796 EchoBASE EB2278 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2278 EcoGene EG12375 http://www.ecogene.org/geneInfo.php?eg_id=EG12375 EnsemblBacteria AAC73999 http://www.ensemblgenomes.org/id/AAC73999 EnsemblBacteria AAC73999 http://www.ensemblgenomes.org/id/AAC73999 EnsemblBacteria BAA35657 http://www.ensemblgenomes.org/id/BAA35657 EnsemblBacteria BAA35657 http://www.ensemblgenomes.org/id/BAA35657 EnsemblBacteria BAA35657 http://www.ensemblgenomes.org/id/BAA35657 EnsemblBacteria b0913 http://www.ensemblgenomes.org/id/b0913 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0030420 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030420 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.60.15.10 http://www.cathdb.info/version/latest/superfamily/3.60.15.10 GeneID 945531 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945531 HOGENOM HOG000262044 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000262044&db=HOGENOM6 InParanoid P37443 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37443 InterPro IPR001279 http://www.ebi.ac.uk/interpro/entry/IPR001279 InterPro IPR004477 http://www.ebi.ac.uk/interpro/entry/IPR004477 InterPro IPR004797 http://www.ebi.ac.uk/interpro/entry/IPR004797 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW5120 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5120 KEGG_Gene eco:b0913 http://www.genome.jp/dbget-bin/www_bget?eco:b0913 KEGG_Orthology KO:K02238 http://www.genome.jp/dbget-bin/www_bget?KO:K02238 OMA VHLMVIS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VHLMVIS PSORT swissprot:YCAI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCAI_ECOLI PSORT-B swissprot:YCAI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCAI_ECOLI PSORT2 swissprot:YCAI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCAI_ECOLI Pfam PF00753 http://pfam.xfam.org/family/PF00753 Pfam PF03772 http://pfam.xfam.org/family/PF03772 Phobius swissprot:YCAI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCAI_ECOLI PhylomeDB P37443 http://phylomedb.org/?seqid=P37443 ProteinModelPortal P37443 http://www.proteinmodelportal.org/query/uniprot/P37443 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8094880 http://www.ncbi.nlm.nih.gov/pubmed/8094880 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415433 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415433 RefSeq WP_000705764 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000705764 SMART SM00849 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00849 STRING 511145.b0913 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0913&targetmode=cogs STRING COG0658 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0658&targetmode=cogs STRING COG2333 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2333&targetmode=cogs SUPFAM SSF56281 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56281 TIGRFAMs TIGR00360 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00360 TIGRFAMs TIGR00361 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00361 UniProtKB YCAI_ECOLI http://www.uniprot.org/uniprot/YCAI_ECOLI UniProtKB-AC P37443 http://www.uniprot.org/uniprot/P37443 charge swissprot:YCAI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCAI_ECOLI eggNOG COG0658 http://eggnogapi.embl.de/nog_data/html/tree/COG0658 eggNOG COG2333 http://eggnogapi.embl.de/nog_data/html/tree/COG2333 eggNOG ENOG4108EQH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108EQH epestfind swissprot:YCAI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCAI_ECOLI garnier swissprot:YCAI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCAI_ECOLI helixturnhelix swissprot:YCAI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCAI_ECOLI hmoment swissprot:YCAI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCAI_ECOLI iep swissprot:YCAI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCAI_ECOLI inforesidue swissprot:YCAI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCAI_ECOLI octanol swissprot:YCAI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCAI_ECOLI pepcoil swissprot:YCAI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCAI_ECOLI pepdigest swissprot:YCAI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCAI_ECOLI pepinfo swissprot:YCAI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCAI_ECOLI pepnet swissprot:YCAI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCAI_ECOLI pepstats swissprot:YCAI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCAI_ECOLI pepwheel swissprot:YCAI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCAI_ECOLI pepwindow swissprot:YCAI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCAI_ECOLI sigcleave swissprot:YCAI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCAI_ECOLI ## Database ID URL or Descriptions # BioGrid 4263259 223 # COFACTOR Name=FMN; Xref=ChEBI:CHEBI 58210; # EcoGene EG11199 mioC # FUNCTION MIOC_ECOLI Probable electron transporter required for biotin synthase activity. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0010181 FMN binding; IDA:EcoCyc. # GO_process GO:0009102 biotin biosynthetic process; IDA:EcoCyc. # GO_process GO:0055114 oxidation-reduction process; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.360 -; 1. # IntAct P03817 4 # InterPro IPR008254 Flavodoxin/NO_synth # InterPro IPR029039 Flavoprotein-like_dom # Organism MIOC_ECOLI Escherichia coli (strain K12) # PATRIC 32122983 VBIEscCol129921_3867 # PDB 2HNA NMR; -; A=1-147 # PDB 2HNB NMR; -; A=1-147 # PIR G65177 QQEC16 # PROSITE PS50902 FLAVODOXIN_LIKE # Pfam PF00258 Flavodoxin_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MIOC_ECOLI Protein MioC # RefSeq NP_418198 NC_000913.3 # RefSeq WP_000763724 NZ_LN832404.1 # RefSeq YP_006952151 NC_019049.1 # SIMILARITY Belongs to the flavodoxin family. MioC subfamily. {ECO 0000305}. # SIMILARITY Contains 1 flavodoxin-like domain. {ECO:0000255|PROSITE-ProRule PRU00088}. # SUBUNIT Homodimer. {ECO 0000305}. # SUPFAM SSF52218 SSF52218 # eggNOG COG0716 LUCA # eggNOG ENOG4105QTB Bacteria BLAST swissprot:MIOC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MIOC_ECOLI BioCyc ECOL316407:JW3720-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3720-MONOMER BioCyc EcoCyc:EG11199-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11199-MONOMER COG COG0716 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0716 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1016/0378-1119(83)90087-2 http://dx.doi.org/10.1016/0378-1119(83)90087-2 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2240799 http://dx.doi.org/10.1042/bj2240799 DOI 10.1073/pnas.76.2.575 http://dx.doi.org/10.1073/pnas.76.2.575 DOI 10.1073/pnas.76.2.580 http://dx.doi.org/10.1073/pnas.76.2.580 DOI 10.1074/jbc.M004497200 http://dx.doi.org/10.1074/jbc.M004497200 DOI 10.1093/nar/20.12.3029 http://dx.doi.org/10.1093/nar/20.12.3029 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01657 http://www.ebi.ac.uk/ena/data/view/J01657 EMBL K00826 http://www.ebi.ac.uk/ena/data/view/K00826 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00308 http://www.ebi.ac.uk/ena/data/view/V00308 EMBL X01631 http://www.ebi.ac.uk/ena/data/view/X01631 EchoBASE EB1185 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1185 EcoGene EG11199 http://www.ecogene.org/geneInfo.php?eg_id=EG11199 EnsemblBacteria AAC76765 http://www.ensemblgenomes.org/id/AAC76765 EnsemblBacteria AAC76765 http://www.ensemblgenomes.org/id/AAC76765 EnsemblBacteria BAE77546 http://www.ensemblgenomes.org/id/BAE77546 EnsemblBacteria BAE77546 http://www.ensemblgenomes.org/id/BAE77546 EnsemblBacteria BAE77546 http://www.ensemblgenomes.org/id/BAE77546 EnsemblBacteria b3742 http://www.ensemblgenomes.org/id/b3742 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0010181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010181 GO_process GO:0009102 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009102 GO_process GO:0055114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.360 http://www.cathdb.info/version/latest/superfamily/3.40.50.360 GeneID 13909069 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13909069 GeneID 948249 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948249 HOGENOM HOG000030545 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000030545&db=HOGENOM6 InParanoid P03817 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P03817 IntAct P03817 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P03817* InterPro IPR008254 http://www.ebi.ac.uk/interpro/entry/IPR008254 InterPro IPR029039 http://www.ebi.ac.uk/interpro/entry/IPR029039 KEGG_Gene ecj:JW3720 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3720 KEGG_Gene eco:b3742 http://www.genome.jp/dbget-bin/www_bget?eco:b3742 KEGG_Orthology KO:K06205 http://www.genome.jp/dbget-bin/www_bget?KO:K06205 OMA IDVTQHE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IDVTQHE PDB 2HNA http://www.ebi.ac.uk/pdbe-srv/view/entry/2HNA PDB 2HNB http://www.ebi.ac.uk/pdbe-srv/view/entry/2HNB PDBsum 2HNA http://www.ebi.ac.uk/pdbsum/2HNA PDBsum 2HNB http://www.ebi.ac.uk/pdbsum/2HNB PROSITE PS50902 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50902 PSORT swissprot:MIOC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MIOC_ECOLI PSORT-B swissprot:MIOC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MIOC_ECOLI PSORT2 swissprot:MIOC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MIOC_ECOLI Pfam PF00258 http://pfam.xfam.org/family/PF00258 Phobius swissprot:MIOC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MIOC_ECOLI PhylomeDB P03817 http://phylomedb.org/?seqid=P03817 ProteinModelPortal P03817 http://www.proteinmodelportal.org/query/uniprot/P03817 PubMed 10913144 http://www.ncbi.nlm.nih.gov/pubmed/10913144 PubMed 1620598 http://www.ncbi.nlm.nih.gov/pubmed/1620598 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 370832 http://www.ncbi.nlm.nih.gov/pubmed/370832 PubMed 370833 http://www.ncbi.nlm.nih.gov/pubmed/370833 PubMed 6169112 http://www.ncbi.nlm.nih.gov/pubmed/6169112 PubMed 6357950 http://www.ncbi.nlm.nih.gov/pubmed/6357950 PubMed 6395859 http://www.ncbi.nlm.nih.gov/pubmed/6395859 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418198 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418198 RefSeq WP_000763724 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000763724 RefSeq YP_006952151 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_006952151 SMR P03817 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P03817 STRING 511145.b3742 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3742&targetmode=cogs STRING COG0716 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0716&targetmode=cogs SUPFAM SSF52218 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52218 UniProtKB MIOC_ECOLI http://www.uniprot.org/uniprot/MIOC_ECOLI UniProtKB-AC P03817 http://www.uniprot.org/uniprot/P03817 charge swissprot:MIOC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MIOC_ECOLI eggNOG COG0716 http://eggnogapi.embl.de/nog_data/html/tree/COG0716 eggNOG ENOG4105QTB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105QTB epestfind swissprot:MIOC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MIOC_ECOLI garnier swissprot:MIOC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MIOC_ECOLI helixturnhelix swissprot:MIOC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MIOC_ECOLI hmoment swissprot:MIOC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MIOC_ECOLI iep swissprot:MIOC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MIOC_ECOLI inforesidue swissprot:MIOC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MIOC_ECOLI octanol swissprot:MIOC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MIOC_ECOLI pepcoil swissprot:MIOC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MIOC_ECOLI pepdigest swissprot:MIOC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MIOC_ECOLI pepinfo swissprot:MIOC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MIOC_ECOLI pepnet swissprot:MIOC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MIOC_ECOLI pepstats swissprot:MIOC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MIOC_ECOLI pepwheel swissprot:MIOC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MIOC_ECOLI pepwindow swissprot:MIOC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MIOC_ECOLI sigcleave swissprot:MIOC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MIOC_ECOLI ## Database ID URL or Descriptions # BioGrid 4260075 295 # CDD cd06174 MFS # EcoGene EG13878 mdtH # FUNCTION MDTH_ECOLI Confers resistance to norfloxacin and enoxacin. {ECO 0000269|PubMed 11566977}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005215 transporter activity; IEA:UniProtKB-HAMAP. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GO_process GO:0055085 transmembrane transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0008150 biological_process # GOslim_process GO:0055085 transmembrane transport # HAMAP MF_01529 MFS_MdtH # INDUCTION Induced at least fivefold by indole in a dose-dependent manner. {ECO:0000269|PubMed 15686558}. # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # InterPro IPR022855 Multidrug-R_MdtH # KEGG_Brite ko02000 Transporters # Organism MDTH_ECOLI Escherichia coli (strain K12) # PATRIC 32117369 VBIEscCol129921_1107 # PIR F64849 F64849 # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MDTH_ECOLI Multidrug resistance protein MdtH # RefSeq NP_415583 NC_000913.3 # RefSeq WP_000092206 NZ_LN832404.1 # SIMILARITY Belongs to the major facilitator superfamily. DHA1 family. MdtH (TC 2.A.1.2.21) subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION MDTH_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.2.21 the major facilitator superfamily (mfs) # eggNOG ENOG4105EV4 Bacteria # eggNOG ENOG410XSK2 LUCA BLAST swissprot:MDTH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MDTH_ECOLI BioCyc ECOL316407:JW1052-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1052-MONOMER BioCyc EcoCyc:B1065-MONOMER http://biocyc.org/getid?id=EcoCyc:B1065-MONOMER COG COG0477 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0477 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.272.17.11236 http://dx.doi.org/10.1074/jbc.272.17.11236 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.2004.04449.x http://dx.doi.org/10.1111/j.1365-2958.2004.04449.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.183.20.5803-5812.2001 http://dx.doi.org/10.1128/JB.183.20.5803-5812.2001 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X92076 http://www.ebi.ac.uk/ena/data/view/X92076 EchoBASE EB3637 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3637 EcoGene EG13878 http://www.ecogene.org/geneInfo.php?eg_id=EG13878 EnsemblBacteria AAC74149 http://www.ensemblgenomes.org/id/AAC74149 EnsemblBacteria AAC74149 http://www.ensemblgenomes.org/id/AAC74149 EnsemblBacteria BAA35873 http://www.ensemblgenomes.org/id/BAA35873 EnsemblBacteria BAA35873 http://www.ensemblgenomes.org/id/BAA35873 EnsemblBacteria BAA35873 http://www.ensemblgenomes.org/id/BAA35873 EnsemblBacteria b1065 http://www.ensemblgenomes.org/id/b1065 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 946920 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946920 HAMAP MF_01529 http://hamap.expasy.org/unirule/MF_01529 HOGENOM HOG000266157 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000266157&db=HOGENOM6 InParanoid P69367 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P69367 IntAct P69367 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69367* InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 InterPro IPR022855 http://www.ebi.ac.uk/interpro/entry/IPR022855 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1052 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1052 KEGG_Gene eco:b1065 http://www.genome.jp/dbget-bin/www_bget?eco:b1065 KEGG_Orthology KO:K08162 http://www.genome.jp/dbget-bin/www_bget?KO:K08162 OMA AWYLPAW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AWYLPAW PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:MDTH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MDTH_ECOLI PSORT-B swissprot:MDTH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MDTH_ECOLI PSORT2 swissprot:MDTH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MDTH_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:MDTH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MDTH_ECOLI PhylomeDB P69367 http://phylomedb.org/?seqid=P69367 ProteinModelPortal P69367 http://www.proteinmodelportal.org/query/uniprot/P69367 PubMed 11566977 http://www.ncbi.nlm.nih.gov/pubmed/11566977 PubMed 15686558 http://www.ncbi.nlm.nih.gov/pubmed/15686558 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9111025 http://www.ncbi.nlm.nih.gov/pubmed/9111025 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415583 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415583 RefSeq WP_000092206 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000092206 STRING 511145.b1065 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1065&targetmode=cogs STRING COG0477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0477&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.2.21 http://www.tcdb.org/search/result.php?tc=2.A.1.2.21 UniProtKB MDTH_ECOLI http://www.uniprot.org/uniprot/MDTH_ECOLI UniProtKB-AC P69367 http://www.uniprot.org/uniprot/P69367 charge swissprot:MDTH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MDTH_ECOLI eggNOG ENOG4105EV4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EV4 eggNOG ENOG410XSK2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XSK2 epestfind swissprot:MDTH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MDTH_ECOLI garnier swissprot:MDTH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MDTH_ECOLI helixturnhelix swissprot:MDTH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MDTH_ECOLI hmoment swissprot:MDTH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MDTH_ECOLI iep swissprot:MDTH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MDTH_ECOLI inforesidue swissprot:MDTH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MDTH_ECOLI octanol swissprot:MDTH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MDTH_ECOLI pepcoil swissprot:MDTH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MDTH_ECOLI pepdigest swissprot:MDTH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MDTH_ECOLI pepinfo swissprot:MDTH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MDTH_ECOLI pepnet swissprot:MDTH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MDTH_ECOLI pepstats swissprot:MDTH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MDTH_ECOLI pepwheel swissprot:MDTH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MDTH_ECOLI pepwindow swissprot:MDTH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MDTH_ECOLI sigcleave swissprot:MDTH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MDTH_ECOLI ## Database ID URL or Descriptions # BioGrid 4262204 7 # COFACTOR Name=FAD; Xref=ChEBI:CHEBI 57692; Evidence={ECO:0000305}; # EcoGene EG11564 fixC # FUNCTION FIXC_ECOLI Could be part of an electron transfer system required for anaerobic carnitine reduction. # GO_function GO:0016491 oxidoreductase activity; IEA:UniProtKB-KW. # GO_function GO:0071949 FAD binding; IEA:InterPro. # GO_process GO:0009437 carnitine metabolic process; IEP:EcoliWiki. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.50.50.60 -; 1. # IntAct P68644 8 # InterPro IPR002938 FAD-bd # InterPro IPR023753 FAD/NAD-binding_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00910 Nitrogen metabolism # Organism FIXC_ECOLI Escherichia coli (strain K12) # PATRIC 32115185 VBIEscCol129921_0044 # PIR C64725 C64725 # Pfam PF01494 FAD_binding_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FIXC_ECOLI Protein FixC # RefSeq NP_414585 NC_000913.3 # RefSeq WP_001287715 NZ_LN832404.1 # SIMILARITY Belongs to the ETF-QO/FixC family. {ECO 0000305}. # SUPFAM SSF51905 SSF51905; 2 # eggNOG COG0644 LUCA # eggNOG ENOG4105DWH Bacteria BLAST swissprot:FIXC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FIXC_ECOLI BioCyc ECOL316407:JW0042-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0042-MONOMER BioCyc EcoCyc:EG11564-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11564-MONOMER COG COG0644 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0644 DOI 10.1002/jobm.3620350404 http://dx.doi.org/10.1002/jobm.3620350404 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.14.4044-4047.2002 http://dx.doi.org/10.1128/JB.184.14.4044-4047.2002 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X71977 http://www.ebi.ac.uk/ena/data/view/X71977 EchoBASE EB1525 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1525 EcoGene EG11564 http://www.ecogene.org/geneInfo.php?eg_id=EG11564 EnsemblBacteria AAC73154 http://www.ensemblgenomes.org/id/AAC73154 EnsemblBacteria AAC73154 http://www.ensemblgenomes.org/id/AAC73154 EnsemblBacteria BAB96611 http://www.ensemblgenomes.org/id/BAB96611 EnsemblBacteria BAB96611 http://www.ensemblgenomes.org/id/BAB96611 EnsemblBacteria BAB96611 http://www.ensemblgenomes.org/id/BAB96611 EnsemblBacteria b0043 http://www.ensemblgenomes.org/id/b0043 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0071949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071949 GO_process GO:0009437 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009437 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 GeneID 948958 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948958 HOGENOM HOG000018936 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000018936&db=HOGENOM6 InParanoid P68644 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P68644 IntAct P68644 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P68644* InterPro IPR002938 http://www.ebi.ac.uk/interpro/entry/IPR002938 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0042 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0042 KEGG_Gene eco:b0043 http://www.genome.jp/dbget-bin/www_bget?eco:b0043 KEGG_Orthology KO:K00313 http://www.genome.jp/dbget-bin/www_bget?KO:K00313 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 OMA WMNTIAN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WMNTIAN PSORT swissprot:FIXC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FIXC_ECOLI PSORT-B swissprot:FIXC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FIXC_ECOLI PSORT2 swissprot:FIXC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FIXC_ECOLI Pfam PF01494 http://pfam.xfam.org/family/PF01494 Phobius swissprot:FIXC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FIXC_ECOLI PhylomeDB P68644 http://phylomedb.org/?seqid=P68644 ProteinModelPortal P68644 http://www.proteinmodelportal.org/query/uniprot/P68644 PubMed 12081978 http://www.ncbi.nlm.nih.gov/pubmed/12081978 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7473063 http://www.ncbi.nlm.nih.gov/pubmed/7473063 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414585 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414585 RefSeq WP_001287715 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001287715 SMR P68644 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P68644 STRING 511145.b0043 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0043&targetmode=cogs STRING COG0644 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0644&targetmode=cogs SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 UniProtKB FIXC_ECOLI http://www.uniprot.org/uniprot/FIXC_ECOLI UniProtKB-AC P68644 http://www.uniprot.org/uniprot/P68644 charge swissprot:FIXC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FIXC_ECOLI eggNOG COG0644 http://eggnogapi.embl.de/nog_data/html/tree/COG0644 eggNOG ENOG4105DWH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DWH epestfind swissprot:FIXC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FIXC_ECOLI garnier swissprot:FIXC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FIXC_ECOLI helixturnhelix swissprot:FIXC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FIXC_ECOLI hmoment swissprot:FIXC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FIXC_ECOLI iep swissprot:FIXC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FIXC_ECOLI inforesidue swissprot:FIXC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FIXC_ECOLI octanol swissprot:FIXC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FIXC_ECOLI pepcoil swissprot:FIXC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FIXC_ECOLI pepdigest swissprot:FIXC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FIXC_ECOLI pepinfo swissprot:FIXC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FIXC_ECOLI pepnet swissprot:FIXC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FIXC_ECOLI pepstats swissprot:FIXC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FIXC_ECOLI pepwheel swissprot:FIXC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FIXC_ECOLI pepwindow swissprot:FIXC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FIXC_ECOLI sigcleave swissprot:FIXC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FIXC_ECOLI ## Database ID URL or Descriptions # BioGrid 4259910 253 # EcoGene EG10607 mrdB # FUNCTION RODA_ECOLI Required for the maintenance of the rod cell shape. Required for the expression of the enzymatic activity of the penicillin-binding protein 2 (PBP2). {ECO 0000269|PubMed 2644207}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0007049 cell cycle; IEA:InterPro. # GO_process GO:0008360 regulation of cell shape; IMP:EcoliWiki. # GO_process GO:0051301 cell division; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0007049 cell cycle # GOslim_process GO:0008150 biological_process # GOslim_process GO:0051301 cell division # InterPro IPR001182 Cell_cycle_FtsW/RodA # InterPro IPR011923 RodA_shape # InterPro IPR018365 Cell_cycle_FtsW-rel_CS # KEGG_Brite ko03036 Chromosome # Organism RODA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30474 PTHR30474 # PANTHER PTHR30474:SF1 PTHR30474:SF1 # PATRIC 32116451 VBIEscCol129921_0665 # PIR JT0500 BVECRD # PROSITE PS00428 FTSW_RODA_SPOVE # Pfam PF01098 FTSW_RODA_SPOVE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RODA_ECOLI Rod shape-determining protein RodA # RefSeq NP_415167 NC_000913.3 # RefSeq WP_000131719 NZ_LN832404.1 # SIMILARITY Belongs to the SEDS family. RodA subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION RODA_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.103.1 the bacterial murein precursor exporter (mpe) family # TIGRFAMs TIGR02210 rodA_shape # eggNOG COG0772 LUCA # eggNOG ENOG4105CNI Bacteria BLAST swissprot:RODA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RODA_ECOLI BioCyc ECOL316407:JW0629-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0629-MONOMER BioCyc EcoCyc:EG10607-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10607-MONOMER COG COG0772 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0772 DIP DIP-48062N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48062N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M18276 http://www.ebi.ac.uk/ena/data/view/M18276 EMBL M22857 http://www.ebi.ac.uk/ena/data/view/M22857 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB0602 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0602 EcoGene EG10607 http://www.ecogene.org/geneInfo.php?eg_id=EG10607 EnsemblBacteria AAC73735 http://www.ensemblgenomes.org/id/AAC73735 EnsemblBacteria AAC73735 http://www.ensemblgenomes.org/id/AAC73735 EnsemblBacteria BAA35277 http://www.ensemblgenomes.org/id/BAA35277 EnsemblBacteria BAA35277 http://www.ensemblgenomes.org/id/BAA35277 EnsemblBacteria BAA35277 http://www.ensemblgenomes.org/id/BAA35277 EnsemblBacteria b0634 http://www.ensemblgenomes.org/id/b0634 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GeneID 945238 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945238 HOGENOM HOG000282686 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000282686&db=HOGENOM6 InParanoid P0ABG7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABG7 IntAct P0ABG7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABG7* InterPro IPR001182 http://www.ebi.ac.uk/interpro/entry/IPR001182 InterPro IPR011923 http://www.ebi.ac.uk/interpro/entry/IPR011923 InterPro IPR018365 http://www.ebi.ac.uk/interpro/entry/IPR018365 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene ecj:JW0629 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0629 KEGG_Gene eco:b0634 http://www.genome.jp/dbget-bin/www_bget?eco:b0634 KEGG_Orthology KO:K05837 http://www.genome.jp/dbget-bin/www_bget?KO:K05837 MINT MINT-1235519 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1235519 OMA ATIAWYL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ATIAWYL PANTHER PTHR30474 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30474 PANTHER PTHR30474:SF1 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30474:SF1 PROSITE PS00428 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00428 PSORT swissprot:RODA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RODA_ECOLI PSORT-B swissprot:RODA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RODA_ECOLI PSORT2 swissprot:RODA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RODA_ECOLI Pfam PF01098 http://pfam.xfam.org/family/PF01098 Phobius swissprot:RODA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RODA_ECOLI PhylomeDB P0ABG7 http://phylomedb.org/?seqid=P0ABG7 ProteinModelPortal P0ABG7 http://www.proteinmodelportal.org/query/uniprot/P0ABG7 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2644207 http://www.ncbi.nlm.nih.gov/pubmed/2644207 PubMed 3316191 http://www.ncbi.nlm.nih.gov/pubmed/3316191 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415167 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415167 RefSeq WP_000131719 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000131719 STRING 511145.b0634 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0634&targetmode=cogs STRING COG0772 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0772&targetmode=cogs TCDB 2.A.103.1 http://www.tcdb.org/search/result.php?tc=2.A.103.1 TIGRFAMs TIGR02210 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02210 UniProtKB RODA_ECOLI http://www.uniprot.org/uniprot/RODA_ECOLI UniProtKB-AC P0ABG7 http://www.uniprot.org/uniprot/P0ABG7 charge swissprot:RODA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RODA_ECOLI eggNOG COG0772 http://eggnogapi.embl.de/nog_data/html/tree/COG0772 eggNOG ENOG4105CNI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CNI epestfind swissprot:RODA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RODA_ECOLI garnier swissprot:RODA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RODA_ECOLI helixturnhelix swissprot:RODA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RODA_ECOLI hmoment swissprot:RODA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RODA_ECOLI iep swissprot:RODA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RODA_ECOLI inforesidue swissprot:RODA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RODA_ECOLI octanol swissprot:RODA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RODA_ECOLI pepcoil swissprot:RODA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RODA_ECOLI pepdigest swissprot:RODA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RODA_ECOLI pepinfo swissprot:RODA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RODA_ECOLI pepnet swissprot:RODA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RODA_ECOLI pepstats swissprot:RODA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RODA_ECOLI pepwheel swissprot:RODA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RODA_ECOLI pepwindow swissprot:RODA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RODA_ECOLI sigcleave swissprot:RODA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RODA_ECOLI ## Database ID URL or Descriptions # AltName CYSK_ECOLI O-acetylserine (thiol)-lyase A # AltName CYSK_ECOLI O-acetylserine sulfhydrylase A # AltName CYSK_ECOLI S-carboxymethylcysteine synthase # AltName CYSK_ECOLI Sulfate starvation-induced protein 5 # BIOPHYSICOCHEMICAL PROPERTIES CYSK_ECOLI Kinetic parameters KM=40 mM for 3-chloro-L-alanine {ECO 0000269|Ref.6}; KM=15.4 mM for thioglycolate {ECO 0000269|Ref.6}; pH dependence Optimum pH is 9-10.5. {ECO 0000269|Ref.6}; Temperature dependence Optimum temperature is 50 degrees Celsius. {ECO 0000269|Ref.6}; # BioGrid 4259701 7 # CATALYTIC ACTIVITY 3-chloro-L-alanine + thioglycolate = S- carboxymethyl-L-cysteine + chloride. {ECO 0000269|Ref.6}. # CATALYTIC ACTIVITY O-acetyl-L-serine + hydrogen sulfide = L- cysteine + acetate. {ECO 0000269|Ref.6}. # COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI 597326; Evidence={ECO:0000269|Ref.6}; # DISRUPTION PHENOTYPE Significant decrease in tRNA nuclease activity of contact-dependent growth inhibitor CdiA-CT from strain 536 / UPEC (deletion in strain BW25113) (PubMed:22333533). {ECO 0000269|PubMed:22333533}. # EcoGene EG10192 cysK # FUNCTION CYSK_ECOLI In addition to its role in cysteine synthesis, stimulates the tRNase activity of CdiA-CT from E.coli strain 536 / UPEC; stimulation does not require O-acetylserine sulfhydrylase activity. CdiA is the toxic component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system. CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion (experiments done in strains BW25113 and X90, both K12 derivatives). This protein is not required for CDI of strain EC93, whose toxin may function by forming inner cell membrane pores. {ECO 0000269|PubMed 22333533}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0009333 cysteine synthase complex; IDA:EcoCyc. # GO_function GO:0004124 cysteine synthase activity; IDA:EcoliWiki. # GO_function GO:0016740 transferase activity; IDA:EcoliWiki. # GO_function GO:0030170 pyridoxal phosphate binding; IDA:EcoCyc. # GO_function GO:0050272 S-carboxymethylcysteine synthase activity; IEA:UniProtKB-EC. # GO_function GO:0080146 L-cysteine desulfhydrase activity; IMP:EcoCyc. # GO_process GO:0006535 cysteine biosynthetic process from serine; IDA:EcoCyc. # GO_process GO:0008652 cellular amino acid biosynthetic process; IDA:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # INDUCTION CYSK_ECOLI Repressed by sulfate or cysteine. # IntAct P0ABK5 14 # InterPro IPR001216 P-phosphate_BS # InterPro IPR001926 TrpB-like_PLP-dep # InterPro IPR005856 Cys_synth # InterPro IPR005859 CysK # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00270 Cysteine and methionine metabolism # KEGG_Pathway ko00920 Sulfur metabolism # Organism CYSK_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-cysteine biosynthesis; L- cysteine from L-serine step 2/2. # PATRIC 32120211 VBIEscCol129921_2508 # PDB 5J43 X-ray; 2.70 A; A/E=1-323 # PDB 5J5V X-ray; 2.75 A; A/D=1-323 # PIR E65015 SYECAC # PROSITE PS00901 CYS_SYNTHASE # Pfam PF00291 PALP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CYSK_ECOLI Cysteine synthase A # RefSeq NP_416909 NC_000913.3 # RefSeq WP_000034402 NZ_LN832404.1 # SIMILARITY Belongs to the cysteine synthase/cystathionine beta- synthase family. {ECO 0000305}. # SUBUNIT CYSK_ECOLI Homodimer (Ref.6). Forms a cysteine synthase complex with 1 copy of CysE (By similarity). Interacts with CdiA-CT from strain 536 / UPEC, this is blocked upon preincubation with O-acetyl-L- serine. CysK forms a complex with CdiA-CT/CdiI (PubMed 22333533). {ECO 0000250|UniProtKB P0A1E3, ECO 0000269|PubMed 22333533, ECO 0000269|Ref.6}. # SUPFAM SSF53686 SSF53686 # TIGRFAMs TIGR01136 cysKM # TIGRFAMs TIGR01139 cysK # UniPathway UPA00136 UER00200 # eggNOG COG0031 LUCA # eggNOG ENOG4105C6T Bacteria BLAST swissprot:CYSK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CYSK_ECOLI BioCyc ECOL316407:JW2407-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2407-MONOMER BioCyc EcoCyc:ACSERLYA-MONOMER http://biocyc.org/getid?id=EcoCyc:ACSERLYA-MONOMER BioCyc MetaCyc:ACSERLYA-MONOMER http://biocyc.org/getid?id=MetaCyc:ACSERLYA-MONOMER COG COG0031 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0031 DIP DIP-36170N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36170N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.90.11.5011 http://dx.doi.org/10.1073/pnas.90.11.5011 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1101/gad.182345.111 http://dx.doi.org/10.1101/gad.182345.111 DOI 10.1111/j.1365-2958.1988.tb00089.x http://dx.doi.org/10.1111/j.1365-2958.1988.tb00089.x DOI 10.1111/j.1432-1033.1996.0773u.x http://dx.doi.org/10.1111/j.1432-1033.1996.0773u.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.5.1.47 http://www.genome.jp/dbget-bin/www_bget?EC:2.5.1.47 EC_number EC:4.5.1.5 {ECO:0000269|Ref.6} http://www.genome.jp/dbget-bin/www_bget?EC:4.5.1.5 {ECO:0000269|Ref.6} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M21451 http://www.ebi.ac.uk/ena/data/view/M21451 EMBL M21994 http://www.ebi.ac.uk/ena/data/view/M21994 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X12615 http://www.ebi.ac.uk/ena/data/view/X12615 ENZYME 2.5.1.47 http://enzyme.expasy.org/EC/2.5.1.47 ENZYME 4.5.1.5 {ECO:0000269|Ref.6} http://enzyme.expasy.org/EC/4.5.1.5 {ECO:0000269|Ref.6} EchoBASE EB0189 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0189 EcoGene EG10192 http://www.ecogene.org/geneInfo.php?eg_id=EG10192 EnsemblBacteria AAC75467 http://www.ensemblgenomes.org/id/AAC75467 EnsemblBacteria AAC75467 http://www.ensemblgenomes.org/id/AAC75467 EnsemblBacteria BAA16288 http://www.ensemblgenomes.org/id/BAA16288 EnsemblBacteria BAA16288 http://www.ensemblgenomes.org/id/BAA16288 EnsemblBacteria BAA16288 http://www.ensemblgenomes.org/id/BAA16288 EnsemblBacteria b2414 http://www.ensemblgenomes.org/id/b2414 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0009333 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009333 GO_function GO:0004124 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004124 GO_function GO:0016740 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016740 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_function GO:0050272 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050272 GO_function GO:0080146 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0080146 GO_process GO:0006535 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006535 GO_process GO:0008652 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008652 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 946877 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946877 HOGENOM HOG000217394 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000217394&db=HOGENOM6 InParanoid P0ABK5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABK5 IntAct P0ABK5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABK5* IntEnz 2.5.1.47 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.5.1.47 IntEnz 4.5.1.5 {ECO:0000269|Ref.6} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.5.1.5 {ECO:0000269|Ref.6} InterPro IPR001216 http://www.ebi.ac.uk/interpro/entry/IPR001216 InterPro IPR001926 http://www.ebi.ac.uk/interpro/entry/IPR001926 InterPro IPR005856 http://www.ebi.ac.uk/interpro/entry/IPR005856 InterPro IPR005859 http://www.ebi.ac.uk/interpro/entry/IPR005859 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2407 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2407 KEGG_Gene eco:b2414 http://www.genome.jp/dbget-bin/www_bget?eco:b2414 KEGG_Orthology KO:K01738 http://www.genome.jp/dbget-bin/www_bget?KO:K01738 KEGG_Pathway ko00270 http://www.genome.jp/kegg-bin/show_pathway?ko00270 KEGG_Pathway ko00920 http://www.genome.jp/kegg-bin/show_pathway?ko00920 KEGG_Reaction rn:R00897 http://www.genome.jp/dbget-bin/www_bget?rn:R00897 KEGG_Reaction rn:R03601 http://www.genome.jp/dbget-bin/www_bget?rn:R03601 KEGG_Reaction rn:R04859 http://www.genome.jp/dbget-bin/www_bget?rn:R04859 MINT MINT-1240013 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1240013 OMA VKCRIGS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VKCRIGS PDB 5J43 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J43 PDB 5J5V http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5V PDBsum 5J43 http://www.ebi.ac.uk/pdbsum/5J43 PDBsum 5J5V http://www.ebi.ac.uk/pdbsum/5J5V PROSITE PS00901 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00901 PSORT swissprot:CYSK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CYSK_ECOLI PSORT-B swissprot:CYSK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CYSK_ECOLI PSORT2 swissprot:CYSK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CYSK_ECOLI Pfam PF00291 http://pfam.xfam.org/family/PF00291 Phobius swissprot:CYSK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CYSK_ECOLI PhylomeDB P0ABK5 http://phylomedb.org/?seqid=P0ABK5 ProteinModelPortal P0ABK5 http://www.proteinmodelportal.org/query/uniprot/P0ABK5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22333533 http://www.ncbi.nlm.nih.gov/pubmed/22333533 PubMed 2457575 http://www.ncbi.nlm.nih.gov/pubmed/2457575 PubMed 3062311 http://www.ncbi.nlm.nih.gov/pubmed/3062311 PubMed 3290198 http://www.ncbi.nlm.nih.gov/pubmed/3290198 PubMed 8506346 http://www.ncbi.nlm.nih.gov/pubmed/8506346 PubMed 8774726 http://www.ncbi.nlm.nih.gov/pubmed/8774726 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_416909 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416909 RefSeq WP_000034402 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000034402 SMR P0ABK5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABK5 STRING 511145.b2414 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2414&targetmode=cogs STRING COG0031 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0031&targetmode=cogs SUPFAM SSF53686 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53686 SWISS-2DPAGE P0ABK5 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0ABK5 TIGRFAMs TIGR01136 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01136 TIGRFAMs TIGR01139 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01139 UniProtKB CYSK_ECOLI http://www.uniprot.org/uniprot/CYSK_ECOLI UniProtKB-AC P0ABK5 http://www.uniprot.org/uniprot/P0ABK5 charge swissprot:CYSK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CYSK_ECOLI eggNOG COG0031 http://eggnogapi.embl.de/nog_data/html/tree/COG0031 eggNOG ENOG4105C6T http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C6T epestfind swissprot:CYSK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CYSK_ECOLI garnier swissprot:CYSK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CYSK_ECOLI helixturnhelix swissprot:CYSK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CYSK_ECOLI hmoment swissprot:CYSK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CYSK_ECOLI iep swissprot:CYSK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CYSK_ECOLI inforesidue swissprot:CYSK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CYSK_ECOLI octanol swissprot:CYSK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CYSK_ECOLI pepcoil swissprot:CYSK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CYSK_ECOLI pepdigest swissprot:CYSK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CYSK_ECOLI pepinfo swissprot:CYSK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CYSK_ECOLI pepnet swissprot:CYSK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CYSK_ECOLI pepstats swissprot:CYSK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CYSK_ECOLI pepwheel swissprot:CYSK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CYSK_ECOLI pepwindow swissprot:CYSK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CYSK_ECOLI sigcleave swissprot:CYSK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CYSK_ECOLI ## Database ID URL or Descriptions # CDD cd01948 EAL # CDD cd06170 LuxR_C_like # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # Gene3D 3.20.20.450 -; 1. # InterPro IPR000792 Tscrpt_reg_LuxR_C # InterPro IPR001633 EAL_dom # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR016032 Sig_transdc_resp-reg_C-effctor # Organism YUAB_ECOLI Escherichia coli (strain K12) # PROSITE PS50883 EAL # Pfam PF00196 GerE # Pfam PF00563 EAL # RecName YUAB_ECOLI Uncharacterized HTH-type transcriptional regulator YuaB # RefSeq NP_061390 NC_002483.1 # RefSeq WP_001092154 NZ_CP014273.1 # SIMILARITY Contains 1 EAL domain. {ECO:0000255|PROSITE- ProRule PRU00074}. # SIMILARITY Contains 1 HTH luxR-type DNA-binding domain. {ECO 0000305}. # SMART SM00052 EAL # SMART SM00421 HTH_LUXR # SUPFAM SSF141868 SSF141868 # SUPFAM SSF46894 SSF46894 BLAST swissprot:YUAB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YUAB_ECOLI EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 3.20.20.450 http://www.cathdb.info/version/latest/superfamily/3.20.20.450 GeneID 1263551 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263551 InterPro IPR000792 http://www.ebi.ac.uk/interpro/entry/IPR000792 InterPro IPR001633 http://www.ebi.ac.uk/interpro/entry/IPR001633 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR016032 http://www.ebi.ac.uk/interpro/entry/IPR016032 OMA EITEHEN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EITEHEN PROSITE PS50883 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50883 PSORT swissprot:YUAB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YUAB_ECOLI PSORT-B swissprot:YUAB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YUAB_ECOLI PSORT2 swissprot:YUAB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YUAB_ECOLI Pfam PF00196 http://pfam.xfam.org/family/PF00196 Pfam PF00563 http://pfam.xfam.org/family/PF00563 Phobius swissprot:YUAB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YUAB_ECOLI PhylomeDB Q9JMT8 http://phylomedb.org/?seqid=Q9JMT8 ProteinModelPortal Q9JMT8 http://www.proteinmodelportal.org/query/uniprot/Q9JMT8 RefSeq NP_061390 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061390 RefSeq WP_001092154 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001092154 SMART SM00052 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00052 SMART SM00421 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00421 SMR Q9JMT8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9JMT8 SUPFAM SSF141868 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF141868 SUPFAM SSF46894 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46894 UniProtKB YUAB_ECOLI http://www.uniprot.org/uniprot/YUAB_ECOLI UniProtKB-AC Q9JMT8 http://www.uniprot.org/uniprot/Q9JMT8 charge swissprot:YUAB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YUAB_ECOLI epestfind swissprot:YUAB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YUAB_ECOLI garnier swissprot:YUAB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YUAB_ECOLI helixturnhelix swissprot:YUAB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YUAB_ECOLI hmoment swissprot:YUAB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YUAB_ECOLI iep swissprot:YUAB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YUAB_ECOLI inforesidue swissprot:YUAB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YUAB_ECOLI octanol swissprot:YUAB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YUAB_ECOLI pepcoil swissprot:YUAB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YUAB_ECOLI pepdigest swissprot:YUAB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YUAB_ECOLI pepinfo swissprot:YUAB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YUAB_ECOLI pepnet swissprot:YUAB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YUAB_ECOLI pepstats swissprot:YUAB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YUAB_ECOLI pepwheel swissprot:YUAB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YUAB_ECOLI pepwindow swissprot:YUAB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YUAB_ECOLI sigcleave swissprot:YUAB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YUAB_ECOLI ## Database ID URL or Descriptions # AltName NADE_ECOLI Nicotinamide adenine dinucleotide synthetase # AltName NADE_ECOLI Nitrogen regulatory protein # BioGrid 4262229 9 # CATALYTIC ACTIVITY NADE_ECOLI ATP + deamido-NAD(+) + NH(3) = AMP + diphosphate + NAD(+). # CDD cd00553 NAD_synthase # EcoGene EG10663 nadE # FUNCTION NADE_ECOLI Catalyzes a key step in NAD biosynthesis, transforming deamido-NAD into NAD by a two-step reaction. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003952 NAD+ synthase (glutamine-hydrolyzing) activity; IEA:InterPro. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008795 NAD+ synthase activity; IDA:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0034355 NAD salvage; IDA:EcoCyc. # GO_process GO:0034628 'de novo' NAD biosynthetic process from aspartate; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.620 -; 1. # HAMAP MF_00193 NadE # IntAct P18843 480 # InterPro IPR003694 NAD_synthase # InterPro IPR014729 Rossmann-like_a/b/a_fold # InterPro IPR022310 NAD/GMP_synthase # InterPro IPR022926 NH(3)-dep_NAD(+)_synth # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00760 Nicotinate and nicotinamide metabolism # Organism NADE_ECOLI Escherichia coli (strain K12) # PATHWAY Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (ammonia route) step 1/1. # PATRIC 32118789 VBIEscCol129921_1812 # PDB 1WXE X-ray; 1.90 A; A=1-275 # PDB 1WXF X-ray; 2.30 A; A=1-275 # PDB 1WXG X-ray; 1.90 A; A=1-275 # PDB 1WXH X-ray; 1.90 A; A=1-275 # PDB 1WXI X-ray; 1.70 A; A=1-275 # PIR D64933 D64933 # PTM NADE_ECOLI May be phosphorylated. # Pfam PF02540 NAD_synthase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NADE_ECOLI NH(3)-dependent NAD(+) synthetase # RefSeq NP_416254 NC_000913.3 # RefSeq WP_000175026 NZ_LN832404.1 # SIMILARITY Belongs to the NAD synthetase family. {ECO 0000305}. # SUBUNIT NADE_ECOLI Homodimer. # TIGRFAMs TIGR00552 nadE # UniPathway UPA00253 UER00333 # eggNOG COG0171 LUCA # eggNOG ENOG4107RA1 Bacteria BLAST swissprot:NADE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NADE_ECOLI BioCyc ECOL316407:JW1729-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1729-MONOMER BioCyc EcoCyc:NAD-SYNTH-MONOMER http://biocyc.org/getid?id=EcoCyc:NAD-SYNTH-MONOMER BioCyc MetaCyc:NAD-SYNTH-MONOMER http://biocyc.org/getid?id=MetaCyc:NAD-SYNTH-MONOMER COG COG0171 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0171 DIP DIP-10295N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10295N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M413195200 http://dx.doi.org/10.1074/jbc.M413195200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.3.1.5 http://www.genome.jp/dbget-bin/www_bget?EC:6.3.1.5 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M15328 http://www.ebi.ac.uk/ena/data/view/M15328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 6.3.1.5 http://enzyme.expasy.org/EC/6.3.1.5 EchoBASE EB0657 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0657 EcoGene EG10663 http://www.ecogene.org/geneInfo.php?eg_id=EG10663 EnsemblBacteria AAC74810 http://www.ensemblgenomes.org/id/AAC74810 EnsemblBacteria AAC74810 http://www.ensemblgenomes.org/id/AAC74810 EnsemblBacteria BAA15529 http://www.ensemblgenomes.org/id/BAA15529 EnsemblBacteria BAA15529 http://www.ensemblgenomes.org/id/BAA15529 EnsemblBacteria BAA15529 http://www.ensemblgenomes.org/id/BAA15529 EnsemblBacteria b1740 http://www.ensemblgenomes.org/id/b1740 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003952 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003952 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008795 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008795 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0034355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034355 GO_process GO:0034628 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034628 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 GeneID 946946 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946946 HAMAP MF_00193 http://hamap.expasy.org/unirule/MF_00193 HOGENOM HOG000238070 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000238070&db=HOGENOM6 InParanoid P18843 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P18843 IntAct P18843 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P18843* IntEnz 6.3.1.5 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.1.5 InterPro IPR003694 http://www.ebi.ac.uk/interpro/entry/IPR003694 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 InterPro IPR022310 http://www.ebi.ac.uk/interpro/entry/IPR022310 InterPro IPR022926 http://www.ebi.ac.uk/interpro/entry/IPR022926 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1729 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1729 KEGG_Gene eco:b1740 http://www.genome.jp/dbget-bin/www_bget?eco:b1740 KEGG_Orthology KO:K01916 http://www.genome.jp/dbget-bin/www_bget?KO:K01916 KEGG_Pathway ko00760 http://www.genome.jp/kegg-bin/show_pathway?ko00760 KEGG_Reaction rn:R00189 http://www.genome.jp/dbget-bin/www_bget?rn:R00189 MINT MINT-1232772 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1232772 OMA AKIIEGW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AKIIEGW PDB 1WXE http://www.ebi.ac.uk/pdbe-srv/view/entry/1WXE PDB 1WXF http://www.ebi.ac.uk/pdbe-srv/view/entry/1WXF PDB 1WXG http://www.ebi.ac.uk/pdbe-srv/view/entry/1WXG PDB 1WXH http://www.ebi.ac.uk/pdbe-srv/view/entry/1WXH PDB 1WXI http://www.ebi.ac.uk/pdbe-srv/view/entry/1WXI PDBsum 1WXE http://www.ebi.ac.uk/pdbsum/1WXE PDBsum 1WXF http://www.ebi.ac.uk/pdbsum/1WXF PDBsum 1WXG http://www.ebi.ac.uk/pdbsum/1WXG PDBsum 1WXH http://www.ebi.ac.uk/pdbsum/1WXH PDBsum 1WXI http://www.ebi.ac.uk/pdbsum/1WXI PSORT swissprot:NADE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NADE_ECOLI PSORT-B swissprot:NADE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NADE_ECOLI PSORT2 swissprot:NADE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NADE_ECOLI Pfam PF02540 http://pfam.xfam.org/family/PF02540 Phobius swissprot:NADE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NADE_ECOLI PhylomeDB P18843 http://phylomedb.org/?seqid=P18843 ProteinModelPortal P18843 http://www.proteinmodelportal.org/query/uniprot/P18843 PubMed 1512214 http://www.ncbi.nlm.nih.gov/pubmed/1512214 PubMed 15699042 http://www.ncbi.nlm.nih.gov/pubmed/15699042 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3025172 http://www.ncbi.nlm.nih.gov/pubmed/3025172 PubMed 8195100 http://www.ncbi.nlm.nih.gov/pubmed/8195100 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_416254 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416254 RefSeq WP_000175026 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000175026 SMR P18843 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P18843 STRING 511145.b1740 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1740&targetmode=cogs STRING COG0171 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0171&targetmode=cogs SWISS-2DPAGE P18843 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P18843 TIGRFAMs TIGR00552 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00552 UniProtKB NADE_ECOLI http://www.uniprot.org/uniprot/NADE_ECOLI UniProtKB-AC P18843 http://www.uniprot.org/uniprot/P18843 charge swissprot:NADE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NADE_ECOLI eggNOG COG0171 http://eggnogapi.embl.de/nog_data/html/tree/COG0171 eggNOG ENOG4107RA1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107RA1 epestfind swissprot:NADE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NADE_ECOLI garnier swissprot:NADE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NADE_ECOLI helixturnhelix swissprot:NADE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NADE_ECOLI hmoment swissprot:NADE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NADE_ECOLI iep swissprot:NADE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NADE_ECOLI inforesidue swissprot:NADE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NADE_ECOLI octanol swissprot:NADE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NADE_ECOLI pepcoil swissprot:NADE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NADE_ECOLI pepdigest swissprot:NADE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NADE_ECOLI pepinfo swissprot:NADE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NADE_ECOLI pepnet swissprot:NADE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NADE_ECOLI pepstats swissprot:NADE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NADE_ECOLI pepwheel swissprot:NADE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NADE_ECOLI pepwindow swissprot:NADE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NADE_ECOLI sigcleave swissprot:NADE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NADE_ECOLI ## Database ID URL or Descriptions # AltName CYOB_ECOLI Cytochrome b562-o complex subunit I # AltName CYOB_ECOLI Cytochrome o ubiquinol oxidase subunit 1 # AltName CYOB_ECOLI Oxidase bo(3) subunit 1 # AltName CYOB_ECOLI Ubiquinol oxidase chain A # AltName CYOB_ECOLI Ubiquinol oxidase polypeptide I # AltName CYOB_ECOLI Ubiquinol oxidase subunit 1 # BIOPHYSICOCHEMICAL PROPERTIES CYOB_ECOLI Kinetic parameters KM=50 uM for ubiquinol-1 {ECO 0000269|PubMed 6365921}; KM=50 uM for ubiquinol-6 {ECO 0000269|PubMed 6365921}; Vmax=15.5 umol/min/nmol enzyme with ubiquinol-1 {ECO 0000269|PubMed 6365921}; Vmax=12.6 umol/min/nmol enzyme with ubiquinol-6 {ECO 0000269|PubMed 6365921}; pH dependence Optimum pH is 7.4. {ECO 0000269|PubMed 6365921}; # BioGrid 4259710 224 # CATALYTIC ACTIVITY 2 ubiquinol + O(2) + n H(+)(Side 1) = 2 ubiquinone + 2 H(2)O + n H(+)(Side 2). {ECO:0000269|PubMed 6365921}. # COFACTOR Name=Cu(2+); Xref=ChEBI:CHEBI 29036; Note=Binds 1 copper B ion per subunit.; # COFACTOR Name=a quinone; Xref=ChEBI:CHEBI 36141; Note=Binds 1 high-affinity quinone that appears to function as a tightly bound cofactor (QH), forming a semiquinone intermediate in the reaction.; # COFACTOR Name=heme b; Xref=ChEBI:CHEBI 60344; Note=Binds 1 low-spin heme b per subunit.; # COFACTOR Name=heme o; Xref=ChEBI:CHEBI 24480; Note=Binds 1 high-spin heme o per subunit.; # DISRUPTION PHENOTYPE CYOB_ECOLI Increased reduction of the ubiquinone pool (in aerobically grown minimal medium with glucose). {ECO 0000269|PubMed 19542282, ECO 0000269|PubMed 22843529}. # ENZYME REGULATION Competitively inhibited by piericidin A, non- competitively inhibited by 2-n-heptyl-4-hydroxyquinoline N-oxide, NaN(3) and KCN; 50% inhibition occurs at 2 uM, 2 uM, 15 mM and 10 uM, respectively. Inhibited by Zn(2+) and Cd(2+). {ECO:0000269|PubMed 6365921}. # EcoGene EG10179 cyoB # FUNCTION CYOB_ECOLI Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron. Protons are probably pumped via D- and K- channels found in this subunit (PubMed 11017202). {ECO 0000269|PubMed 11017202, ECO 0000269|PubMed 19542282, ECO 0000269|PubMed 22843529, ECO 0000269|PubMed 6308657}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0009319 cytochrome o ubiquinol oxidase complex; IDA:EcoCyc. # GO_component GO:0070469 respiratory chain; IEA:UniProtKB-KW. # GO_function GO:0004129 cytochrome-c oxidase activity; IEA:InterPro. # GO_function GO:0005506 iron ion binding; IEA:InterPro. # GO_function GO:0005507 copper ion binding; IDA:EcoCyc. # GO_function GO:0009055 electron carrier activity; IDA:EcoCyc. # GO_function GO:0009486 cytochrome bo3 ubiquinol oxidase activity; IDA:EcoCyc. # GO_function GO:0015078 hydrogen ion transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0015453 oxidoreduction-driven active transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0016682 oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor; IEA:InterPro. # GO_function GO:0020037 heme binding; IDA:EcoCyc. # GO_function GO:0048039 ubiquinone binding; IDA:EcoCyc. # GO_process GO:0009060 aerobic respiration; IMP:EcoCyc. # GO_process GO:0015990 electron transport coupled proton transport; IDA:EcoCyc. # GO_process GO:0019646 aerobic electron transport chain; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0055085 transmembrane transport # Gene3D 1.20.210.10 -; 1. # INTERACTION CYOB_ECOLI P77806 ybdL; NbExp=3; IntAct=EBI-2932021, EBI-543661; # IntAct P0ABI8 3 # InterPro IPR000883 COX1 # InterPro IPR014207 Cyt_c_ubiqinol_oxidase_su1 # InterPro IPR023615 Cyt_c_Oxase_su1_BS # InterPro IPR023616 Cyt_c_oxase-like_su1_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00190 Oxidative phosphorylation # MISCELLANEOUS CYOB_ECOLI Ubiquinol oxidase catalyzes the terminal step in the electron transport chain. # Organism CYOB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10422 PTHR10422 # PATRIC 32116013 VBIEscCol129921_0448 # PDB 1FFT X-ray; 3.50 A; A/F=1-663 # PIR B42226 B42226 # PRINTS PR01165 CYCOXIDASEI # PROSITE PS00077 COX1_CUB # PROSITE PS50855 COX1 # Pfam PF00115 COX1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CYOB_ECOLI Cytochrome bo(3) ubiquinol oxidase subunit 1 # RefSeq NP_414965 NC_000913.3 # RefSeq WP_000467180 NZ_LN832404.1 # SIMILARITY Belongs to the heme-copper respiratory oxidase family. {ECO 0000305}. # SUBCELLULAR LOCATION CYOB_ECOLI Cell inner membrane {ECO 0000269|PubMed 6365921}; Multi-pass membrane protein {ECO 0000269|PubMed 6365921}. # SUBUNIT CYOB_ECOLI Heterooctamer of two A chains, two B chains, two C chains and two D chains. {ECO 0000269|PubMed 11017202, ECO 0000269|PubMed 6308657}. # SUPFAM SSF81442 SSF81442 # TCDB 3.D.4.5 the proton-translocating cytochrome oxidase (cox) superfamily # TIGRFAMs TIGR02843 CyoB # eggNOG COG0843 LUCA # eggNOG ENOG4105BZ9 Bacteria BLAST swissprot:CYOB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CYOB_ECOLI BioCyc ECOL316407:JW0421-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0421-MONOMER BioCyc EcoCyc:CYOB-MONOMER http://biocyc.org/getid?id=EcoCyc:CYOB-MONOMER BioCyc MetaCyc:CYOB-MONOMER http://biocyc.org/getid?id=MetaCyc:CYOB-MONOMER COG COG0843 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0843 DIP DIP-47943N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47943N DOI 10.1016/0005-2728(90)90231-R http://dx.doi.org/10.1016/0005-2728(90)90231-R DOI 10.1021/bi012146w http://dx.doi.org/10.1021/bi012146w DOI 10.1038/82824 http://dx.doi.org/10.1038/82824 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.80.16.4889 http://dx.doi.org/10.1073/pnas.80.16.4889 DOI 10.1074/jbc.M611595200 http://dx.doi.org/10.1074/jbc.M611595200 DOI 10.1093/oxfordjournals.jbchem.a021770 http://dx.doi.org/10.1093/oxfordjournals.jbchem.a021770 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AEM.01507-12 http://dx.doi.org/10.1128/AEM.01507-12 DOI 10.1128/JB.00562-09 http://dx.doi.org/10.1128/JB.00562-09 DisProt DP00088 http://www.disprot.org/protein.php?id=DP00088 EC_number EC:1.10.3.10 http://www.genome.jp/dbget-bin/www_bget?EC:1.10.3.10 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J05492 http://www.ebi.ac.uk/ena/data/view/J05492 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 ENZYME 1.10.3.10 http://enzyme.expasy.org/EC/1.10.3.10 EchoBASE EB0176 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0176 EcoGene EG10179 http://www.ecogene.org/geneInfo.php?eg_id=EG10179 EnsemblBacteria AAC73534 http://www.ensemblgenomes.org/id/AAC73534 EnsemblBacteria AAC73534 http://www.ensemblgenomes.org/id/AAC73534 EnsemblBacteria BAE76211 http://www.ensemblgenomes.org/id/BAE76211 EnsemblBacteria BAE76211 http://www.ensemblgenomes.org/id/BAE76211 EnsemblBacteria BAE76211 http://www.ensemblgenomes.org/id/BAE76211 EnsemblBacteria b0431 http://www.ensemblgenomes.org/id/b0431 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0009319 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009319 GO_component GO:0070469 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070469 GO_function GO:0004129 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004129 GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0005507 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005507 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0009486 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009486 GO_function GO:0015078 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015078 GO_function GO:0015453 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015453 GO_function GO:0016682 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016682 GO_function GO:0020037 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0020037 GO_function GO:0048039 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048039 GO_process GO:0009060 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009060 GO_process GO:0015990 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015990 GO_process GO:0019646 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019646 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 1.20.210.10 http://www.cathdb.info/version/latest/superfamily/1.20.210.10 GeneID 945615 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945615 HOGENOM HOG000085275 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000085275&db=HOGENOM6 InParanoid P0ABI8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABI8 IntAct P0ABI8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABI8* IntEnz 1.10.3.10 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.10.3.10 InterPro IPR000883 http://www.ebi.ac.uk/interpro/entry/IPR000883 InterPro IPR014207 http://www.ebi.ac.uk/interpro/entry/IPR014207 InterPro IPR023615 http://www.ebi.ac.uk/interpro/entry/IPR023615 InterPro IPR023616 http://www.ebi.ac.uk/interpro/entry/IPR023616 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0421 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0421 KEGG_Gene eco:b0431 http://www.genome.jp/dbget-bin/www_bget?eco:b0431 KEGG_Orthology KO:K02298 http://www.genome.jp/dbget-bin/www_bget?KO:K02298 KEGG_Pathway ko00190 http://www.genome.jp/kegg-bin/show_pathway?ko00190 OMA FCGKRLF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FCGKRLF PANTHER PTHR10422 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10422 PDB 1FFT http://www.ebi.ac.uk/pdbe-srv/view/entry/1FFT PDBsum 1FFT http://www.ebi.ac.uk/pdbsum/1FFT PRINTS PR01165 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01165 PROSITE PS00077 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00077 PROSITE PS50855 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50855 PSORT swissprot:CYOB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CYOB_ECOLI PSORT-B swissprot:CYOB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CYOB_ECOLI PSORT2 swissprot:CYOB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CYOB_ECOLI Pfam PF00115 http://pfam.xfam.org/family/PF00115 Phobius swissprot:CYOB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CYOB_ECOLI PhylomeDB P0ABI8 http://phylomedb.org/?seqid=P0ABI8 ProteinModelPortal P0ABI8 http://www.proteinmodelportal.org/query/uniprot/P0ABI8 PubMed 11017202 http://www.ncbi.nlm.nih.gov/pubmed/11017202 PubMed 12186553 http://www.ncbi.nlm.nih.gov/pubmed/12186553 PubMed 1309808 http://www.ncbi.nlm.nih.gov/pubmed/1309808 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17267395 http://www.ncbi.nlm.nih.gov/pubmed/17267395 PubMed 19542282 http://www.ncbi.nlm.nih.gov/pubmed/19542282 PubMed 2162835 http://www.ncbi.nlm.nih.gov/pubmed/2162835 PubMed 2165491 http://www.ncbi.nlm.nih.gov/pubmed/2165491 PubMed 2168206 http://www.ncbi.nlm.nih.gov/pubmed/2168206 PubMed 22843529 http://www.ncbi.nlm.nih.gov/pubmed/22843529 PubMed 6308657 http://www.ncbi.nlm.nih.gov/pubmed/6308657 PubMed 6365921 http://www.ncbi.nlm.nih.gov/pubmed/6365921 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9378723 http://www.ncbi.nlm.nih.gov/pubmed/9378723 RefSeq NP_414965 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414965 RefSeq WP_000467180 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000467180 SMR P0ABI8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABI8 STRING 511145.b0431 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0431&targetmode=cogs STRING COG0843 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0843&targetmode=cogs SUPFAM SSF81442 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81442 TCDB 3.D.4.5 http://www.tcdb.org/search/result.php?tc=3.D.4.5 TIGRFAMs TIGR02843 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02843 UniProtKB CYOB_ECOLI http://www.uniprot.org/uniprot/CYOB_ECOLI UniProtKB-AC P0ABI8 http://www.uniprot.org/uniprot/P0ABI8 charge swissprot:CYOB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CYOB_ECOLI eggNOG COG0843 http://eggnogapi.embl.de/nog_data/html/tree/COG0843 eggNOG ENOG4105BZ9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZ9 epestfind swissprot:CYOB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CYOB_ECOLI garnier swissprot:CYOB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CYOB_ECOLI helixturnhelix swissprot:CYOB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CYOB_ECOLI hmoment swissprot:CYOB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CYOB_ECOLI iep swissprot:CYOB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CYOB_ECOLI inforesidue swissprot:CYOB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CYOB_ECOLI octanol swissprot:CYOB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CYOB_ECOLI pepcoil swissprot:CYOB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CYOB_ECOLI pepdigest swissprot:CYOB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CYOB_ECOLI pepinfo swissprot:CYOB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CYOB_ECOLI pepnet swissprot:CYOB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CYOB_ECOLI pepstats swissprot:CYOB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CYOB_ECOLI pepwheel swissprot:CYOB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CYOB_ECOLI pepwindow swissprot:CYOB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CYOB_ECOLI sigcleave swissprot:CYOB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CYOB_ECOLI ## Database ID URL or Descriptions # BioGrid 4261445 11 # COFACTOR YGBL_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000305}; Note=Binds 1 zinc ion per subunit. {ECO 0000305}; # EcoGene EG13106 ygbL # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0016832 aldehyde-lyase activity; IBA:GO_Central. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0019323 pentose catabolic process; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.225.10 -; 1. # IntAct Q46890 2 # InterPro IPR001303 Aldolase_II/adducin_N # Organism YGBL_ECOLI Escherichia coli (strain K12) # PATRIC 32120880 VBIEscCol129921_2832 # PIR F65054 F65054 # Pfam PF00596 Aldolase_II # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGBL_ECOLI Putative aldolase class 2 protein YgbL # RefSeq NP_417218 NC_000913.3 # RefSeq WP_001278994 NZ_LN832404.1 # SIMILARITY Belongs to the aldolase class II family. AraD/FucA subfamily. {ECO 0000305}. # SMART SM01007 Aldolase_II # SUPFAM SSF53639 SSF53639 # eggNOG COG0235 LUCA # eggNOG ENOG4105FB2 Bacteria BLAST swissprot:YGBL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGBL_ECOLI BioCyc ECOL316407:JW2708-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2708-MONOMER BioCyc EcoCyc:G7419-MONOMER http://biocyc.org/getid?id=EcoCyc:G7419-MONOMER DIP DIP-12113N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12113N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.19.5381-5390.2000 http://dx.doi.org/10.1128/JB.182.19.5381-5390.2000 EMBL AF242208 http://www.ebi.ac.uk/ena/data/view/AF242208 EMBL AF242210 http://www.ebi.ac.uk/ena/data/view/AF242210 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EchoBASE EB2909 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2909 EcoGene EG13106 http://www.ecogene.org/geneInfo.php?eg_id=EG13106 EnsemblBacteria AAC75780 http://www.ensemblgenomes.org/id/AAC75780 EnsemblBacteria AAC75780 http://www.ensemblgenomes.org/id/AAC75780 EnsemblBacteria BAE76815 http://www.ensemblgenomes.org/id/BAE76815 EnsemblBacteria BAE76815 http://www.ensemblgenomes.org/id/BAE76815 EnsemblBacteria BAE76815 http://www.ensemblgenomes.org/id/BAE76815 EnsemblBacteria b2738 http://www.ensemblgenomes.org/id/b2738 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0016832 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016832 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0019323 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019323 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.225.10 http://www.cathdb.info/version/latest/superfamily/3.40.225.10 GeneID 947197 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947197 HOGENOM HOG000218185 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218185&db=HOGENOM6 InParanoid Q46890 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46890 IntAct Q46890 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46890* InterPro IPR001303 http://www.ebi.ac.uk/interpro/entry/IPR001303 KEGG_Gene ecj:JW2708 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2708 KEGG_Gene eco:b2738 http://www.genome.jp/dbget-bin/www_bget?eco:b2738 OMA VMKVGHV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VMKVGHV PSORT swissprot:YGBL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGBL_ECOLI PSORT-B swissprot:YGBL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGBL_ECOLI PSORT2 swissprot:YGBL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGBL_ECOLI Pfam PF00596 http://pfam.xfam.org/family/PF00596 Phobius swissprot:YGBL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGBL_ECOLI PhylomeDB Q46890 http://phylomedb.org/?seqid=Q46890 ProteinModelPortal Q46890 http://www.proteinmodelportal.org/query/uniprot/Q46890 PubMed 10986240 http://www.ncbi.nlm.nih.gov/pubmed/10986240 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417218 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417218 RefSeq WP_001278994 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001278994 SMART SM01007 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01007 SMR Q46890 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46890 STRING 511145.b2738 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2738&targetmode=cogs SUPFAM SSF53639 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53639 UniProtKB YGBL_ECOLI http://www.uniprot.org/uniprot/YGBL_ECOLI UniProtKB-AC Q46890 http://www.uniprot.org/uniprot/Q46890 charge swissprot:YGBL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGBL_ECOLI eggNOG COG0235 http://eggnogapi.embl.de/nog_data/html/tree/COG0235 eggNOG ENOG4105FB2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FB2 epestfind swissprot:YGBL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGBL_ECOLI garnier swissprot:YGBL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGBL_ECOLI helixturnhelix swissprot:YGBL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGBL_ECOLI hmoment swissprot:YGBL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGBL_ECOLI iep swissprot:YGBL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGBL_ECOLI inforesidue swissprot:YGBL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGBL_ECOLI octanol swissprot:YGBL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGBL_ECOLI pepcoil swissprot:YGBL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGBL_ECOLI pepdigest swissprot:YGBL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGBL_ECOLI pepinfo swissprot:YGBL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGBL_ECOLI pepnet swissprot:YGBL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGBL_ECOLI pepstats swissprot:YGBL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGBL_ECOLI pepwheel swissprot:YGBL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGBL_ECOLI pepwindow swissprot:YGBL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGBL_ECOLI sigcleave swissprot:YGBL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGBL_ECOLI ## Database ID URL or Descriptions # BioGrid 4261010 282 # EcoGene EG12135 ompX # GO_component GO:0009279 cell outer membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # Gene3D 2.40.160.20 -; 1. # IntAct P0A917 2 # InterPro IPR000758 Enterovir_OMP # InterPro IPR011250 OMP/PagP_b-brl # InterPro IPR027385 OMP_b-brl # KEGG_Brite ko02000 Transporters # Organism OMPX_ECOLI Escherichia coli (strain K12) # PATRIC 32116831 VBIEscCol129921_0841 # PDB 1ORM NMR; -; A=24-171 # PDB 1Q9F NMR; -; A=24-171 # PDB 1Q9G NMR; -; A=24-171 # PDB 1QJ8 X-ray; 1.90 A; A=24-171 # PDB 1QJ9 X-ray; 2.10 A; A=24-171 # PDB 2M06 NMR; -; A=24-171 # PDB 2M07 NMR; -; A=24-171 # PDB 2MNH NMR; -; A=24-171 # PIR I55173 I55173 # PRINTS PR00316 ENTEROVIROMP # PROSITE PS00694 ENT_VIR_OMP_1 # PROSITE PS00695 ENT_VIR_OMP_2 # Pfam PF13505 OMP_b-brl # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName OMPX_ECOLI Outer membrane protein X # RefSeq NP_415335 NC_000913.3 # RefSeq WP_001295296 NZ_LN832404.1 # SIMILARITY Belongs to the Ail/OmpX/PagC/Lom family. {ECO 0000305}. # SUBCELLULAR LOCATION OMPX_ECOLI Cell outer membrane; Multi-pass membrane protein. # SUPFAM SSF56925 SSF56925 # TCDB 1.B.6.2 the ompa-ompf porin (oop) family # eggNOG COG3637 LUCA # eggNOG ENOG4108T1M Bacteria BLAST swissprot:OMPX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:OMPX_ECOLI BioCyc ECOL316407:JW0799-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0799-MONOMER BioCyc EcoCyc:EG12117-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12117-MONOMER COG COG3637 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3637 DIP DIP-48016N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48016N DOI 10.1002/elps.1150190539 http://dx.doi.org/10.1002/elps.1150190539 DOI 10.1016/S0969-2126(00)80063-5 http://dx.doi.org/10.1016/S0969-2126(00)80063-5 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L37088 http://www.ebi.ac.uk/ena/data/view/L37088 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U04242 http://www.ebi.ac.uk/ena/data/view/U04242 EchoBASE EB2056 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2056 EcoGene EG12135 http://www.ecogene.org/geneInfo.php?eg_id=EG12135 EnsemblBacteria AAC73901 http://www.ensemblgenomes.org/id/AAC73901 EnsemblBacteria AAC73901 http://www.ensemblgenomes.org/id/AAC73901 EnsemblBacteria BAA35486 http://www.ensemblgenomes.org/id/BAA35486 EnsemblBacteria BAA35486 http://www.ensemblgenomes.org/id/BAA35486 EnsemblBacteria BAA35486 http://www.ensemblgenomes.org/id/BAA35486 EnsemblBacteria b0814 http://www.ensemblgenomes.org/id/b0814 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 Gene3D 2.40.160.20 http://www.cathdb.info/version/latest/superfamily/2.40.160.20 GeneID 944967 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944967 HOGENOM HOG000118160 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118160&db=HOGENOM6 IntAct P0A917 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A917* InterPro IPR000758 http://www.ebi.ac.uk/interpro/entry/IPR000758 InterPro IPR011250 http://www.ebi.ac.uk/interpro/entry/IPR011250 InterPro IPR027385 http://www.ebi.ac.uk/interpro/entry/IPR027385 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0799 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0799 KEGG_Gene eco:b0814 http://www.genome.jp/dbget-bin/www_bget?eco:b0814 KEGG_Orthology KO:K11934 http://www.genome.jp/dbget-bin/www_bget?KO:K11934 MINT MINT-1256834 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1256834 OMA KYRYEFD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KYRYEFD PDB 1ORM http://www.ebi.ac.uk/pdbe-srv/view/entry/1ORM PDB 1Q9F http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q9F PDB 1Q9G http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q9G PDB 1QJ8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1QJ8 PDB 1QJ9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1QJ9 PDB 2M06 http://www.ebi.ac.uk/pdbe-srv/view/entry/2M06 PDB 2M07 http://www.ebi.ac.uk/pdbe-srv/view/entry/2M07 PDB 2MNH http://www.ebi.ac.uk/pdbe-srv/view/entry/2MNH PDBsum 1ORM http://www.ebi.ac.uk/pdbsum/1ORM PDBsum 1Q9F http://www.ebi.ac.uk/pdbsum/1Q9F PDBsum 1Q9G http://www.ebi.ac.uk/pdbsum/1Q9G PDBsum 1QJ8 http://www.ebi.ac.uk/pdbsum/1QJ8 PDBsum 1QJ9 http://www.ebi.ac.uk/pdbsum/1QJ9 PDBsum 2M06 http://www.ebi.ac.uk/pdbsum/2M06 PDBsum 2M07 http://www.ebi.ac.uk/pdbsum/2M07 PDBsum 2MNH http://www.ebi.ac.uk/pdbsum/2MNH PRINTS PR00316 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00316 PROSITE PS00694 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00694 PROSITE PS00695 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00695 PSORT swissprot:OMPX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:OMPX_ECOLI PSORT-B swissprot:OMPX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:OMPX_ECOLI PSORT2 swissprot:OMPX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:OMPX_ECOLI Pfam PF13505 http://pfam.xfam.org/family/PF13505 Phobius swissprot:OMPX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:OMPX_ECOLI ProteinModelPortal P0A917 http://www.proteinmodelportal.org/query/uniprot/P0A917 PubMed 10545325 http://www.ncbi.nlm.nih.gov/pubmed/10545325 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7836315 http://www.ncbi.nlm.nih.gov/pubmed/7836315 PubMed 8021175 http://www.ncbi.nlm.nih.gov/pubmed/8021175 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9629924 http://www.ncbi.nlm.nih.gov/pubmed/9629924 RefSeq NP_415335 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415335 RefSeq WP_001295296 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295296 SMR P0A917 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A917 STRING 511145.b0814 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0814&targetmode=cogs STRING COG3637 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3637&targetmode=cogs SUPFAM SSF56925 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56925 SWISS-2DPAGE P0A917 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A917 TCDB 1.B.6.2 http://www.tcdb.org/search/result.php?tc=1.B.6.2 UniProtKB OMPX_ECOLI http://www.uniprot.org/uniprot/OMPX_ECOLI UniProtKB-AC P0A917 http://www.uniprot.org/uniprot/P0A917 charge swissprot:OMPX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:OMPX_ECOLI eggNOG COG3637 http://eggnogapi.embl.de/nog_data/html/tree/COG3637 eggNOG ENOG4108T1M http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108T1M epestfind swissprot:OMPX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:OMPX_ECOLI garnier swissprot:OMPX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:OMPX_ECOLI helixturnhelix swissprot:OMPX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:OMPX_ECOLI hmoment swissprot:OMPX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:OMPX_ECOLI iep swissprot:OMPX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:OMPX_ECOLI inforesidue swissprot:OMPX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:OMPX_ECOLI octanol swissprot:OMPX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:OMPX_ECOLI pepcoil swissprot:OMPX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:OMPX_ECOLI pepdigest swissprot:OMPX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:OMPX_ECOLI pepinfo swissprot:OMPX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:OMPX_ECOLI pepnet swissprot:OMPX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:OMPX_ECOLI pepstats swissprot:OMPX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:OMPX_ECOLI pepwheel swissprot:OMPX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:OMPX_ECOLI pepwindow swissprot:OMPX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:OMPX_ECOLI sigcleave swissprot:OMPX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:OMPX_ECOLI ## Database ID URL or Descriptions # BioGrid 4261430 8 # EcoGene EG14218 hyfJ # GO_function GO:0016491 oxidoreductase activity; IEA:UniProtKB-KW. # GOslim_function GO:0016491 oxidoreductase activity # InterPro IPR010005 Formate_DH_maturation_HycH # KEGG_Brite ko01000 Enzymes # Organism HYFJ_ECOLI Escherichia coli (strain K12) # PATRIC 32120367 VBIEscCol129921_2586 # PIR A65025 A65025 # Pfam PF07450 HycH # ProDom PD021295 HycH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HYFJ_ECOLI Hydrogenase-4 component J # RefSeq NP_416985 NC_000913.3 # RefSeq WP_001326580 NZ_LN832404.1 # SIMILARITY To E.coli HycH. {ECO 0000305}. # eggNOG ENOG4105I6X Bacteria # eggNOG ENOG4111Q8X LUCA BLAST swissprot:HYFJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HYFJ_ECOLI BioCyc ECOL316407:JW2475-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2475-MONOMER BioCyc EcoCyc:G7307-MONOMER http://biocyc.org/getid?id=EcoCyc:G7307-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M63654 http://www.ebi.ac.uk/ena/data/view/M63654 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- EchoBASE EB3970 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3970 EcoGene EG14218 http://www.ecogene.org/geneInfo.php?eg_id=EG14218 EnsemblBacteria AAC75543 http://www.ensemblgenomes.org/id/AAC75543 EnsemblBacteria AAC75543 http://www.ensemblgenomes.org/id/AAC75543 EnsemblBacteria BAA16378 http://www.ensemblgenomes.org/id/BAA16378 EnsemblBacteria BAA16378 http://www.ensemblgenomes.org/id/BAA16378 EnsemblBacteria BAA16378 http://www.ensemblgenomes.org/id/BAA16378 EnsemblBacteria b2490 http://www.ensemblgenomes.org/id/b2490 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GeneID 947713 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947713 HOGENOM HOG000278708 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278708&db=HOGENOM6 IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR010005 http://www.ebi.ac.uk/interpro/entry/IPR010005 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2475 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2475 KEGG_Gene eco:b2490 http://www.genome.jp/dbget-bin/www_bget?eco:b2490 KEGG_Orthology KO:K12145 http://www.genome.jp/dbget-bin/www_bget?KO:K12145 OMA LMVKRID http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LMVKRID PSORT swissprot:HYFJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HYFJ_ECOLI PSORT-B swissprot:HYFJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HYFJ_ECOLI PSORT2 swissprot:HYFJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HYFJ_ECOLI Pfam PF07450 http://pfam.xfam.org/family/PF07450 Phobius swissprot:HYFJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HYFJ_ECOLI ProteinModelPortal P77453 http://www.proteinmodelportal.org/query/uniprot/P77453 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416985 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416985 RefSeq WP_001326580 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001326580 STRING 511145.b2490 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2490&targetmode=cogs UniProtKB HYFJ_ECOLI http://www.uniprot.org/uniprot/HYFJ_ECOLI UniProtKB-AC P77453 http://www.uniprot.org/uniprot/P77453 charge swissprot:HYFJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HYFJ_ECOLI eggNOG ENOG4105I6X http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105I6X eggNOG ENOG4111Q8X http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111Q8X epestfind swissprot:HYFJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HYFJ_ECOLI garnier swissprot:HYFJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HYFJ_ECOLI helixturnhelix swissprot:HYFJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HYFJ_ECOLI hmoment swissprot:HYFJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HYFJ_ECOLI iep swissprot:HYFJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HYFJ_ECOLI inforesidue swissprot:HYFJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HYFJ_ECOLI octanol swissprot:HYFJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HYFJ_ECOLI pepcoil swissprot:HYFJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HYFJ_ECOLI pepdigest swissprot:HYFJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HYFJ_ECOLI pepinfo swissprot:HYFJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HYFJ_ECOLI pepnet swissprot:HYFJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HYFJ_ECOLI pepstats swissprot:HYFJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HYFJ_ECOLI pepwheel swissprot:HYFJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HYFJ_ECOLI pepwindow swissprot:HYFJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HYFJ_ECOLI sigcleave swissprot:HYFJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HYFJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4263103 3 # EcoGene EG12907 yhfL # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # InterPro IPR025318 DUF4223 # Organism YHFL_ECOLI Escherichia coli (strain K12) # PATRIC 32122172 VBIEscCol129921_3463 # PIR D65131 D65131 # Pfam PF13978 DUF4223 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHFL_ECOLI Uncharacterized protein YhfL # RefSeq NP_417828 NC_000913.3 # RefSeq WP_001031834 NZ_LN832404.1 # SUBCELLULAR LOCATION YHFL_ECOLI Membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. # eggNOG ENOG4105VYH Bacteria # eggNOG ENOG41127R9 LUCA BLAST swissprot:YHFL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHFL_ECOLI BioCyc ECOL316407:JW3332-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3332-MONOMER BioCyc EcoCyc:G7722-MONOMER http://biocyc.org/getid?id=EcoCyc:G7722-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2744 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2744 EcoGene EG12907 http://www.ecogene.org/geneInfo.php?eg_id=EG12907 EnsemblBacteria AAC76394 http://www.ensemblgenomes.org/id/AAC76394 EnsemblBacteria AAC76394 http://www.ensemblgenomes.org/id/AAC76394 EnsemblBacteria BAE77921 http://www.ensemblgenomes.org/id/BAE77921 EnsemblBacteria BAE77921 http://www.ensemblgenomes.org/id/BAE77921 EnsemblBacteria BAE77921 http://www.ensemblgenomes.org/id/BAE77921 EnsemblBacteria b3369 http://www.ensemblgenomes.org/id/b3369 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GeneID 947879 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947879 HOGENOM HOG000289479 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000289479&db=HOGENOM6 InterPro IPR025318 http://www.ebi.ac.uk/interpro/entry/IPR025318 KEGG_Gene ecj:JW3332 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3332 KEGG_Gene eco:b3369 http://www.genome.jp/dbget-bin/www_bget?eco:b3369 OMA ENKNKTC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ENKNKTC PSORT swissprot:YHFL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHFL_ECOLI PSORT-B swissprot:YHFL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHFL_ECOLI PSORT2 swissprot:YHFL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHFL_ECOLI Pfam PF13978 http://pfam.xfam.org/family/PF13978 Phobius swissprot:YHFL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHFL_ECOLI ProteinModelPortal P64627 http://www.proteinmodelportal.org/query/uniprot/P64627 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417828 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417828 RefSeq WP_001031834 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001031834 STRING 511145.b3369 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3369&targetmode=cogs UniProtKB YHFL_ECOLI http://www.uniprot.org/uniprot/YHFL_ECOLI UniProtKB-AC P64627 http://www.uniprot.org/uniprot/P64627 charge swissprot:YHFL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHFL_ECOLI eggNOG ENOG4105VYH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VYH eggNOG ENOG41127R9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41127R9 epestfind swissprot:YHFL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHFL_ECOLI garnier swissprot:YHFL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHFL_ECOLI helixturnhelix swissprot:YHFL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHFL_ECOLI hmoment swissprot:YHFL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHFL_ECOLI iep swissprot:YHFL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHFL_ECOLI inforesidue swissprot:YHFL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHFL_ECOLI octanol swissprot:YHFL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHFL_ECOLI pepcoil swissprot:YHFL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHFL_ECOLI pepdigest swissprot:YHFL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHFL_ECOLI pepinfo swissprot:YHFL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHFL_ECOLI pepnet swissprot:YHFL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHFL_ECOLI pepstats swissprot:YHFL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHFL_ECOLI pepwheel swissprot:YHFL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHFL_ECOLI pepwindow swissprot:YHFL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHFL_ECOLI sigcleave swissprot:YHFL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHFL_ECOLI ## Database ID URL or Descriptions # BioGrid 4259276 5 # EcoGene EG12791 yhbV # GO_function GO:0008233 peptidase activity; IEA:InterPro. # GOslim_function GO:0008233 peptidase activity # InterPro IPR001539 Peptidase_U32 # Organism YHBV_ECOLI Escherichia coli (strain K12) # PATRIC 32121736 VBIEscCol129921_3254 # PIR C65106 C65106 # Pfam PF01136 Peptidase_U32 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHBV_ECOLI Uncharacterized protein YhbV # RefSeq NP_417628 NC_000913.3 # RefSeq WP_001301318 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA57962.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # eggNOG COG0826 LUCA # eggNOG ENOG4106RZ4 Bacteria BLAST swissprot:YHBV_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHBV_ECOLI BioCyc ECOL316407:JW5530-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5530-MONOMER BioCyc EcoCyc:G7653-MONOMER http://biocyc.org/getid?id=EcoCyc:G7653-MONOMER DIP DIP-12269N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12269N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2643 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2643 EcoGene EG12791 http://www.ecogene.org/geneInfo.php?eg_id=EG12791 EnsemblBacteria AAC76193 http://www.ensemblgenomes.org/id/AAC76193 EnsemblBacteria AAC76193 http://www.ensemblgenomes.org/id/AAC76193 EnsemblBacteria BAE77205 http://www.ensemblgenomes.org/id/BAE77205 EnsemblBacteria BAE77205 http://www.ensemblgenomes.org/id/BAE77205 EnsemblBacteria BAE77205 http://www.ensemblgenomes.org/id/BAE77205 EnsemblBacteria b3159 http://www.ensemblgenomes.org/id/b3159 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GeneID 949117 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949117 HOGENOM HOG000276087 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276087&db=HOGENOM6 InParanoid P45475 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45475 IntAct P45475 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45475* InterPro IPR001539 http://www.ebi.ac.uk/interpro/entry/IPR001539 KEGG_Gene ecj:JW5530 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5530 KEGG_Gene eco:b3159 http://www.genome.jp/dbget-bin/www_bget?eco:b3159 MINT MINT-1294878 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1294878 OMA CCIKYPT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CCIKYPT PSORT swissprot:YHBV_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHBV_ECOLI PSORT-B swissprot:YHBV_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHBV_ECOLI PSORT2 swissprot:YHBV_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHBV_ECOLI Pfam PF01136 http://pfam.xfam.org/family/PF01136 Phobius swissprot:YHBV_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHBV_ECOLI PhylomeDB P45475 http://phylomedb.org/?seqid=P45475 ProteinModelPortal P45475 http://www.proteinmodelportal.org/query/uniprot/P45475 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417628 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417628 RefSeq WP_001301318 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001301318 STRING 511145.b3159 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3159&targetmode=cogs UniProtKB YHBV_ECOLI http://www.uniprot.org/uniprot/YHBV_ECOLI UniProtKB-AC P45475 http://www.uniprot.org/uniprot/P45475 charge swissprot:YHBV_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHBV_ECOLI eggNOG COG0826 http://eggnogapi.embl.de/nog_data/html/tree/COG0826 eggNOG ENOG4106RZ4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106RZ4 epestfind swissprot:YHBV_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHBV_ECOLI garnier swissprot:YHBV_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHBV_ECOLI helixturnhelix swissprot:YHBV_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHBV_ECOLI hmoment swissprot:YHBV_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHBV_ECOLI iep swissprot:YHBV_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHBV_ECOLI inforesidue swissprot:YHBV_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHBV_ECOLI octanol swissprot:YHBV_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHBV_ECOLI pepcoil swissprot:YHBV_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHBV_ECOLI pepdigest swissprot:YHBV_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHBV_ECOLI pepinfo swissprot:YHBV_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHBV_ECOLI pepnet swissprot:YHBV_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHBV_ECOLI pepstats swissprot:YHBV_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHBV_ECOLI pepwheel swissprot:YHBV_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHBV_ECOLI pepwindow swissprot:YHBV_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHBV_ECOLI sigcleave swissprot:YHBV_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHBV_ECOLI ## Database ID URL or Descriptions # BioGrid 4262165 8 # CAUTION Could be the product of a pseudogene. Seems to be an unlikely translation of a REP element. {ECO 0000305}. # EcoGene EG13592 yahH # Organism YAHH_ECOLI Escherichia coli (strain K12) # PATRIC 48659849 VBIEscCol107702_0319 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAHH_ECOLI Putative uncharacterized protein YahH # SEQUENCE CAUTION Sequence=BAE76105.1; Type=Erroneous initiation; Evidence={ECO 0000305}; BLAST swissprot:YAHH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAHH_ECOLI BioCyc ECOL316407:JW5893-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5893-MONOMER BioCyc EcoCyc:MONOMER0-2772 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2772 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG13592 http://www.ecogene.org/geneInfo.php?eg_id=EG13592 EnsemblBacteria BAE76105 http://www.ensemblgenomes.org/id/BAE76105 EnsemblBacteria BAE76105 http://www.ensemblgenomes.org/id/BAE76105 EnsemblBacteria BAE76105 http://www.ensemblgenomes.org/id/BAE76105 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv KEGG_Gene ecj:JW5893 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5893 OMA AHQAFIT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AHQAFIT PSORT swissprot:YAHH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAHH_ECOLI PSORT-B swissprot:YAHH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAHH_ECOLI PSORT2 swissprot:YAHH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAHH_ECOLI Phobius swissprot:YAHH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAHH_ECOLI ProteinModelPortal Q2EEQ3 http://www.proteinmodelportal.org/query/uniprot/Q2EEQ3 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 STRING 316407.85674465 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85674465&targetmode=cogs UniProtKB YAHH_ECOLI http://www.uniprot.org/uniprot/YAHH_ECOLI UniProtKB-AC Q2EEQ3 http://www.uniprot.org/uniprot/Q2EEQ3 charge swissprot:YAHH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAHH_ECOLI epestfind swissprot:YAHH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAHH_ECOLI garnier swissprot:YAHH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAHH_ECOLI helixturnhelix swissprot:YAHH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAHH_ECOLI hmoment swissprot:YAHH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAHH_ECOLI iep swissprot:YAHH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAHH_ECOLI inforesidue swissprot:YAHH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAHH_ECOLI octanol swissprot:YAHH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAHH_ECOLI pepcoil swissprot:YAHH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAHH_ECOLI pepdigest swissprot:YAHH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAHH_ECOLI pepinfo swissprot:YAHH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAHH_ECOLI pepnet swissprot:YAHH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAHH_ECOLI pepstats swissprot:YAHH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAHH_ECOLI pepwheel swissprot:YAHH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAHH_ECOLI pepwindow swissprot:YAHH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAHH_ECOLI sigcleave swissprot:YAHH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAHH_ECOLI ## Database ID URL or Descriptions # BioGrid 4262557 260 # EcoGene EG12290 yiaV # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0055085 transmembrane transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0055085 transmembrane transport # InterPro IPR006143 RND_pump_MFP # InterPro IPR032317 HlyD_D23 # Organism YIAV_ECOLI Escherichia coli (strain K12) # PATRIC 32122648 VBIEscCol129921_3701 # PIR S47807 S47807 # Pfam PF00529 HlyD # Pfam PF16576 HlyD_D23 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIAV_ECOLI Inner membrane protein YiaV # RefSeq NP_418043 NC_000913.3 # RefSeq WP_000364884 NZ_LN832404.1 # SIMILARITY Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. {ECO 0000305}. # SUBCELLULAR LOCATION YIAV_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 8.A.1.1 the membrane fusion protein (mfp) family # eggNOG COG1566 LUCA # eggNOG ENOG4105EFX Bacteria BLAST swissprot:YIAV_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIAV_ECOLI BioCyc ECOL316407:JW3558-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3558-MONOMER BioCyc EcoCyc:EG12290-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12290-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2198 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2198 EcoGene EG12290 http://www.ecogene.org/geneInfo.php?eg_id=EG12290 EnsemblBacteria AAC76610 http://www.ensemblgenomes.org/id/AAC76610 EnsemblBacteria AAC76610 http://www.ensemblgenomes.org/id/AAC76610 EnsemblBacteria BAE77707 http://www.ensemblgenomes.org/id/BAE77707 EnsemblBacteria BAE77707 http://www.ensemblgenomes.org/id/BAE77707 EnsemblBacteria BAE77707 http://www.ensemblgenomes.org/id/BAE77707 EnsemblBacteria b3586 http://www.ensemblgenomes.org/id/b3586 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 948106 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948106 HOGENOM HOG000279244 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000279244&db=HOGENOM6 InParanoid P37683 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37683 InterPro IPR006143 http://www.ebi.ac.uk/interpro/entry/IPR006143 InterPro IPR032317 http://www.ebi.ac.uk/interpro/entry/IPR032317 KEGG_Gene ecj:JW3558 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3558 KEGG_Gene eco:b3586 http://www.genome.jp/dbget-bin/www_bget?eco:b3586 OMA EQESITI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EQESITI PSORT swissprot:YIAV_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIAV_ECOLI PSORT-B swissprot:YIAV_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIAV_ECOLI PSORT2 swissprot:YIAV_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIAV_ECOLI Pfam PF00529 http://pfam.xfam.org/family/PF00529 Pfam PF16576 http://pfam.xfam.org/family/PF16576 Phobius swissprot:YIAV_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIAV_ECOLI PhylomeDB P37683 http://phylomedb.org/?seqid=P37683 ProteinModelPortal P37683 http://www.proteinmodelportal.org/query/uniprot/P37683 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418043 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418043 RefSeq WP_000364884 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000364884 SMR P37683 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37683 STRING 511145.b3586 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3586&targetmode=cogs TCDB 8.A.1.1 http://www.tcdb.org/search/result.php?tc=8.A.1.1 UniProtKB YIAV_ECOLI http://www.uniprot.org/uniprot/YIAV_ECOLI UniProtKB-AC P37683 http://www.uniprot.org/uniprot/P37683 charge swissprot:YIAV_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIAV_ECOLI eggNOG COG1566 http://eggnogapi.embl.de/nog_data/html/tree/COG1566 eggNOG ENOG4105EFX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EFX epestfind swissprot:YIAV_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIAV_ECOLI garnier swissprot:YIAV_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIAV_ECOLI helixturnhelix swissprot:YIAV_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIAV_ECOLI hmoment swissprot:YIAV_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIAV_ECOLI iep swissprot:YIAV_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIAV_ECOLI inforesidue swissprot:YIAV_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIAV_ECOLI octanol swissprot:YIAV_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIAV_ECOLI pepcoil swissprot:YIAV_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIAV_ECOLI pepdigest swissprot:YIAV_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIAV_ECOLI pepinfo swissprot:YIAV_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIAV_ECOLI pepnet swissprot:YIAV_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIAV_ECOLI pepstats swissprot:YIAV_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIAV_ECOLI pepwheel swissprot:YIAV_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIAV_ECOLI pepwindow swissprot:YIAV_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIAV_ECOLI sigcleave swissprot:YIAV_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIAV_ECOLI ## Database ID URL or Descriptions # BioGrid 4262544 9 # EcoGene EG20253 xylR # FUNCTION XYLR_ECOLI Regulatory protein for the xylBAFGHR operon. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IDA:EcoCyc. # GO_function GO:0043565 sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.60 -; 2. # InterPro IPR009057 Homeodomain-like # InterPro IPR018060 HTH_AraC # InterPro IPR018062 HTH_AraC-typ_CS # InterPro IPR020449 Tscrpt_reg_HTH_AraC-type # InterPro IPR028082 Peripla_BP_I # KEGG_Brite ko03000 Transcription factors # Organism XYLR_ECOLI Escherichia coli (strain K12) # PATRIC 32122614 VBIEscCol129921_3684 # PDB 4FE4 X-ray; 3.45 A; A/B/C=1-392 # PDB 4FE7 X-ray; 2.90 A; A=1-392 # PIR S47790 S47790 # PRINTS PR00032 HTHARAC # PROSITE PS00041 HTH_ARAC_FAMILY_1 # PROSITE PS01124 HTH_ARAC_FAMILY_2 # Pfam PF12833 HTH_18 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName XYLR_ECOLI Xylose operon regulatory protein # RefSeq NP_418026 NC_000913.3 # RefSeq WP_000494484 NZ_LN832404.1 # SIMILARITY Contains 1 HTH araC/xylS-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00593}. # SMART SM00342 HTH_ARAC # SUPFAM SSF46689 SSF46689; 2 # SUPFAM SSF53822 SSF53822 # eggNOG ENOG4105T16 Bacteria # eggNOG ENOG410XQWR LUCA BLAST swissprot:XYLR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:XYLR_ECOLI BioCyc ECOL316407:JW3541-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3541-MONOMER BioCyc EcoCyc:EG20253-MONOMER http://biocyc.org/getid?id=EcoCyc:EG20253-MONOMER COG COG1609 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1609 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4154 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4154 EcoGene EG20253 http://www.ecogene.org/geneInfo.php?eg_id=EG20253 EnsemblBacteria AAC76593 http://www.ensemblgenomes.org/id/AAC76593 EnsemblBacteria AAC76593 http://www.ensemblgenomes.org/id/AAC76593 EnsemblBacteria BAE77724 http://www.ensemblgenomes.org/id/BAE77724 EnsemblBacteria BAE77724 http://www.ensemblgenomes.org/id/BAE77724 EnsemblBacteria BAE77724 http://www.ensemblgenomes.org/id/BAE77724 EnsemblBacteria b3569 http://www.ensemblgenomes.org/id/b3569 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 GeneID 948086 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948086 HOGENOM HOG000269135 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000269135&db=HOGENOM6 InParanoid P0ACI3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACI3 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR018060 http://www.ebi.ac.uk/interpro/entry/IPR018060 InterPro IPR018062 http://www.ebi.ac.uk/interpro/entry/IPR018062 InterPro IPR020449 http://www.ebi.ac.uk/interpro/entry/IPR020449 InterPro IPR028082 http://www.ebi.ac.uk/interpro/entry/IPR028082 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW3541 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3541 KEGG_Gene eco:b3569 http://www.genome.jp/dbget-bin/www_bget?eco:b3569 KEGG_Orthology KO:K02529 http://www.genome.jp/dbget-bin/www_bget?KO:K02529 OMA LHQMLHG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LHQMLHG PDB 4FE4 http://www.ebi.ac.uk/pdbe-srv/view/entry/4FE4 PDB 4FE7 http://www.ebi.ac.uk/pdbe-srv/view/entry/4FE7 PDBsum 4FE4 http://www.ebi.ac.uk/pdbsum/4FE4 PDBsum 4FE7 http://www.ebi.ac.uk/pdbsum/4FE7 PRINTS PR00032 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00032 PROSITE PS00041 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00041 PROSITE PS01124 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01124 PSORT swissprot:XYLR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:XYLR_ECOLI PSORT-B swissprot:XYLR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:XYLR_ECOLI PSORT2 swissprot:XYLR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:XYLR_ECOLI Pfam PF12833 http://pfam.xfam.org/family/PF12833 Phobius swissprot:XYLR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:XYLR_ECOLI PhylomeDB P0ACI3 http://phylomedb.org/?seqid=P0ACI3 ProteinModelPortal P0ACI3 http://www.proteinmodelportal.org/query/uniprot/P0ACI3 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418026 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418026 RefSeq WP_000494484 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000494484 SMART SM00342 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00342 SMR P0ACI3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACI3 STRING 511145.b3569 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3569&targetmode=cogs STRING COG1609 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1609&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF53822 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822 UniProtKB XYLR_ECOLI http://www.uniprot.org/uniprot/XYLR_ECOLI UniProtKB-AC P0ACI3 http://www.uniprot.org/uniprot/P0ACI3 charge swissprot:XYLR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:XYLR_ECOLI eggNOG ENOG4105T16 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105T16 eggNOG ENOG410XQWR http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQWR epestfind swissprot:XYLR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:XYLR_ECOLI garnier swissprot:XYLR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:XYLR_ECOLI helixturnhelix swissprot:XYLR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:XYLR_ECOLI hmoment swissprot:XYLR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:XYLR_ECOLI iep swissprot:XYLR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:XYLR_ECOLI inforesidue swissprot:XYLR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:XYLR_ECOLI octanol swissprot:XYLR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:XYLR_ECOLI pepcoil swissprot:XYLR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:XYLR_ECOLI pepdigest swissprot:XYLR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:XYLR_ECOLI pepinfo swissprot:XYLR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:XYLR_ECOLI pepnet swissprot:XYLR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:XYLR_ECOLI pepstats swissprot:XYLR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:XYLR_ECOLI pepwheel swissprot:XYLR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:XYLR_ECOLI pepwindow swissprot:XYLR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:XYLR_ECOLI sigcleave swissprot:XYLR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:XYLR_ECOLI ## Database ID URL or Descriptions # AltName MHPD_ECOLI 2-hydroxypentadienoic acid hydratase # BIOPHYSICOCHEMICAL PROPERTIES MHPD_ECOLI Kinetic parameters KM=41 uM for 2-hydroxy-pentadienoic acid (at pH 6) {ECO 0000269|PubMed 9492273}; pH dependence Optimum pH is 5.5-8.0, but decreases linearly above pH 8.3, and shows an inflection at pH 5.5. {ECO 0000269|PubMed 9492273}; # BRENDA 4.2.1.80 2165 # BioGrid 4260731 5 # CATALYTIC ACTIVITY MHPD_ECOLI 4-hydroxy-2-oxopentanoate = 2-oxopent-4-enoate + H(2)O. # COFACTOR MHPD_ECOLI Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 9492273}; Note=Divalent metal ions. Optimum activity is obtained with Mn(2+). {ECO 0000269|PubMed 9492273}; # ENZYME REGULATION Inhibited by sodium oxalate. {ECO:0000269|PubMed 9492273}. # EcoGene EG14274 mhpD # FUNCTION MHPD_ECOLI Catalyzes the conversion of 2-hydroxypentadienoic acid (enolic form of 2-oxopent-4-enoate) to 4-hydroxy-2-ketopentanoic acid. {ECO 0000269|PubMed 9492273}. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_function GO:0008684 2-oxopent-4-enoate hydratase activity; IDA:EcoCyc. # GO_function GO:0030145 manganese ion binding; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0019380 3-phenylpropionate catabolic process; IEA:UniProtKB-UniPathway. # GO_process GO:0019439 aromatic compound catabolic process; NAS:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.90.850.10 -; 1. # HAMAP MF_01655 MhpD # IntAct P77608 3 # InterPro IPR011234 Fumarylacetoacetase_C-rel # InterPro IPR023793 Keto_pentenoate-hydratase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00360 Phenylalanine metabolism # KEGG_Pathway ko00362 Benzoate degradation # KEGG_Pathway ko00621 Dioxin degradation # KEGG_Pathway ko00622 Xylene degradation # Organism MHPD_ECOLI Escherichia coli (strain K12) # PATHWAY MHPD_ECOLI Aromatic compound metabolism; 3-phenylpropanoate degradation. # PATRIC 32115833 VBIEscCol129921_0358 # PDB 1SV6 X-ray; 2.90 A; A/B/C/D/E=1-269 # PDB 2WQT X-ray; 2.80 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T=1-269 # PIR F64762 F64762 # Pfam PF01557 FAA_hydrolase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MHPD_ECOLI 2-keto-4-pentenoate hydratase # RefSeq NP_414884 NC_000913.3 # RefSeq WP_000160710 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18074.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA13055.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the hydratase/decarboxylase family. MhpD subfamily. {ECO 0000305}. # SUPFAM SSF56529 SSF56529 # eggNOG COG3971 LUCA # eggNOG ENOG4105IKQ Bacteria BLAST swissprot:MHPD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MHPD_ECOLI BioCyc ECOL316407:JW0341-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0341-MONOMER BioCyc EcoCyc:MHPDHYDROL-MONOMER http://biocyc.org/getid?id=EcoCyc:MHPDHYDROL-MONOMER BioCyc MetaCyc:MHPDHYDROL-MONOMER http://biocyc.org/getid?id=MetaCyc:MHPDHYDROL-MONOMER COG COG3971 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3971 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1432-1327.1998.2510098.x http://dx.doi.org/10.1046/j.1432-1327.1998.2510098.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.1.80 http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.80 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D86239 http://www.ebi.ac.uk/ena/data/view/D86239 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EMBL Y09555 http://www.ebi.ac.uk/ena/data/view/Y09555 ENZYME 4.2.1.80 http://enzyme.expasy.org/EC/4.2.1.80 EchoBASE EB4022 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4022 EcoGene EG14274 http://www.ecogene.org/geneInfo.php?eg_id=EG14274 EnsemblBacteria AAC73453 http://www.ensemblgenomes.org/id/AAC73453 EnsemblBacteria AAC73453 http://www.ensemblgenomes.org/id/AAC73453 EnsemblBacteria BAE76132 http://www.ensemblgenomes.org/id/BAE76132 EnsemblBacteria BAE76132 http://www.ensemblgenomes.org/id/BAE76132 EnsemblBacteria BAE76132 http://www.ensemblgenomes.org/id/BAE76132 EnsemblBacteria b0350 http://www.ensemblgenomes.org/id/b0350 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0008684 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008684 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0019380 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019380 GO_process GO:0019439 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019439 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.90.850.10 http://www.cathdb.info/version/latest/superfamily/3.90.850.10 GeneID 944768 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944768 HAMAP MF_01655 http://hamap.expasy.org/unirule/MF_01655 HOGENOM HOG000179637 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000179637&db=HOGENOM6 InParanoid P77608 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77608 IntAct P77608 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77608* IntEnz 4.2.1.80 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.80 InterPro IPR011234 http://www.ebi.ac.uk/interpro/entry/IPR011234 InterPro IPR023793 http://www.ebi.ac.uk/interpro/entry/IPR023793 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0341 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0341 KEGG_Gene eco:b0350 http://www.genome.jp/dbget-bin/www_bget?eco:b0350 KEGG_Orthology KO:K02554 http://www.genome.jp/dbget-bin/www_bget?KO:K02554 KEGG_Pathway ko00360 http://www.genome.jp/kegg-bin/show_pathway?ko00360 KEGG_Pathway ko00362 http://www.genome.jp/kegg-bin/show_pathway?ko00362 KEGG_Pathway ko00621 http://www.genome.jp/kegg-bin/show_pathway?ko00621 KEGG_Pathway ko00622 http://www.genome.jp/kegg-bin/show_pathway?ko00622 KEGG_Reaction rn:R02601 http://www.genome.jp/dbget-bin/www_bget?rn:R02601 KEGG_Reaction rn:R04781 http://www.genome.jp/dbget-bin/www_bget?rn:R04781 KEGG_Reaction rn:R05864 http://www.genome.jp/dbget-bin/www_bget?rn:R05864 OMA IRDWSIG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IRDWSIG PDB 1SV6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1SV6 PDB 2WQT http://www.ebi.ac.uk/pdbe-srv/view/entry/2WQT PDBsum 1SV6 http://www.ebi.ac.uk/pdbsum/1SV6 PDBsum 2WQT http://www.ebi.ac.uk/pdbsum/2WQT PSORT swissprot:MHPD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MHPD_ECOLI PSORT-B swissprot:MHPD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MHPD_ECOLI PSORT2 swissprot:MHPD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MHPD_ECOLI Pfam PF01557 http://pfam.xfam.org/family/PF01557 Phobius swissprot:MHPD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MHPD_ECOLI PhylomeDB P77608 http://phylomedb.org/?seqid=P77608 ProteinModelPortal P77608 http://www.proteinmodelportal.org/query/uniprot/P77608 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9098055 http://www.ncbi.nlm.nih.gov/pubmed/9098055 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9492273 http://www.ncbi.nlm.nih.gov/pubmed/9492273 RefSeq NP_414884 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414884 RefSeq WP_000160710 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000160710 SMR P77608 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77608 STRING 511145.b0350 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0350&targetmode=cogs STRING COG3971 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3971&targetmode=cogs SUPFAM SSF56529 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56529 UniProtKB MHPD_ECOLI http://www.uniprot.org/uniprot/MHPD_ECOLI UniProtKB-AC P77608 http://www.uniprot.org/uniprot/P77608 charge swissprot:MHPD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MHPD_ECOLI eggNOG COG3971 http://eggnogapi.embl.de/nog_data/html/tree/COG3971 eggNOG ENOG4105IKQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105IKQ epestfind swissprot:MHPD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MHPD_ECOLI garnier swissprot:MHPD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MHPD_ECOLI helixturnhelix swissprot:MHPD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MHPD_ECOLI hmoment swissprot:MHPD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MHPD_ECOLI iep swissprot:MHPD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MHPD_ECOLI inforesidue swissprot:MHPD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MHPD_ECOLI octanol swissprot:MHPD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MHPD_ECOLI pepcoil swissprot:MHPD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MHPD_ECOLI pepdigest swissprot:MHPD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MHPD_ECOLI pepinfo swissprot:MHPD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MHPD_ECOLI pepnet swissprot:MHPD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MHPD_ECOLI pepstats swissprot:MHPD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MHPD_ECOLI pepwheel swissprot:MHPD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MHPD_ECOLI pepwindow swissprot:MHPD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MHPD_ECOLI sigcleave swissprot:MHPD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MHPD_ECOLI ## Database ID URL or Descriptions # BioGrid 4259213 18 # BioGrid 4262257 17 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG13520 ygaQ # GO_function GO:0003824 catalytic activity; IEA:InterPro. # GO_process GO:0005975 carbohydrate metabolic process; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0005975 carbohydrate metabolic process # Gene3D 2.60.40.1180 -; 1. # Gene3D 3.20.20.80 -; 2. # InterPro IPR006047 Glyco_hydro_13_cat_dom # InterPro IPR013780 Glyco_hydro_b # InterPro IPR013781 Glyco_hydro_catalytic_dom # InterPro IPR015902 Glyco_hydro_13 # InterPro IPR017853 Glycoside_hydrolase_SF # InterPro IPR020316 Uncharacterised_YgaQ # Organism YGAQ_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10357 PTHR10357; 3 # PATRIC 48664715 VBIEscCol107702_2683 # PIR C65045 C65045 # PIR G65044 G65044 # Pfam PF00128 Alpha-amylase # ProDom PD063434 Putative_uncharacterised_YgaQ # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGAQ_ECOLI Putative uncharacterized protein YgaQ # SEQUENCE CAUTION YGAQ_ECOLI Sequence=BAA16517.2; Type=Erroneous termination; Positions=111, 346, 614; Note=Translated as Trp, Trp, Trp.; Evidence={ECO 0000305}; Sequence=BAE76777.1; Type=Erroneous termination; Positions=111, 346, 614; Note=Translated as Trp, Trp, Trp.; Evidence={ECO 0000305}; Sequence=BAE76778.1; Type=Erroneous termination; Positions=111, 346, 614; Note=Translated as Trp, Trp, Trp.; Evidence={ECO 0000305}; Sequence=U00096; Type=Erroneous termination; Positions=111, 346, 614; Note=Translated as Trp, Trp, Trp.; Evidence={ECO 0000305}; # SMART SM00642 Aamy # SUPFAM SSF51445 SSF51445; 2 # eggNOG COG0366 LUCA # eggNOG ENOG4105E54 Bacteria BLAST swissprot:YGAQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGAQ_ECOLI BioCyc ECOL316407:JW2631-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2631-MONOMER BioCyc ECOL316407:JW2633-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2633-MONOMER BioCyc ECOL316407:JW5425-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5425-MONOMER BioCyc EcoCyc:G7389-MONOMER http://biocyc.org/getid?id=EcoCyc:G7389-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3293 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3293 EcoGene EG13520 http://www.ecogene.org/geneInfo.php?eg_id=EG13520 EnsemblBacteria BAA16517 http://www.ensemblgenomes.org/id/BAA16517 EnsemblBacteria BAA16517 http://www.ensemblgenomes.org/id/BAA16517 EnsemblBacteria BAA16517 http://www.ensemblgenomes.org/id/BAA16517 EnsemblBacteria BAE76777 http://www.ensemblgenomes.org/id/BAE76777 EnsemblBacteria BAE76777 http://www.ensemblgenomes.org/id/BAE76777 EnsemblBacteria BAE76777 http://www.ensemblgenomes.org/id/BAE76777 EnsemblBacteria BAE76778 http://www.ensemblgenomes.org/id/BAE76778 EnsemblBacteria BAE76778 http://www.ensemblgenomes.org/id/BAE76778 EnsemblBacteria BAE76778 http://www.ensemblgenomes.org/id/BAE76778 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003824 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003824 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 Gene3D 2.60.40.1180 http://www.cathdb.info/version/latest/superfamily/2.60.40.1180 Gene3D 3.20.20.80 http://www.cathdb.info/version/latest/superfamily/3.20.20.80 InParanoid P76616 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76616 IntAct P76616 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76616* InterPro IPR006047 http://www.ebi.ac.uk/interpro/entry/IPR006047 InterPro IPR013780 http://www.ebi.ac.uk/interpro/entry/IPR013780 InterPro IPR013781 http://www.ebi.ac.uk/interpro/entry/IPR013781 InterPro IPR015902 http://www.ebi.ac.uk/interpro/entry/IPR015902 InterPro IPR017853 http://www.ebi.ac.uk/interpro/entry/IPR017853 InterPro IPR020316 http://www.ebi.ac.uk/interpro/entry/IPR020316 KEGG_Gene ecj:JW2631 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2631 KEGG_Gene ecj:JW2633 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2633 KEGG_Gene ecj:JW5425 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5425 PANTHER PTHR10357 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10357 PSORT swissprot:YGAQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGAQ_ECOLI PSORT-B swissprot:YGAQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGAQ_ECOLI PSORT2 swissprot:YGAQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGAQ_ECOLI Pfam PF00128 http://pfam.xfam.org/family/PF00128 Phobius swissprot:YGAQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGAQ_ECOLI ProteinModelPortal P76616 http://www.proteinmodelportal.org/query/uniprot/P76616 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SMART SM00642 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00642 STRING 316407.85675510 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85675510&targetmode=cogs SUPFAM SSF51445 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51445 UniProtKB YGAQ_ECOLI http://www.uniprot.org/uniprot/YGAQ_ECOLI UniProtKB-AC P76616 http://www.uniprot.org/uniprot/P76616 charge swissprot:YGAQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGAQ_ECOLI eggNOG COG0366 http://eggnogapi.embl.de/nog_data/html/tree/COG0366 eggNOG ENOG4105E54 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E54 epestfind swissprot:YGAQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGAQ_ECOLI garnier swissprot:YGAQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGAQ_ECOLI helixturnhelix swissprot:YGAQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGAQ_ECOLI hmoment swissprot:YGAQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGAQ_ECOLI iep swissprot:YGAQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGAQ_ECOLI inforesidue swissprot:YGAQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGAQ_ECOLI octanol swissprot:YGAQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGAQ_ECOLI pepcoil swissprot:YGAQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGAQ_ECOLI pepdigest swissprot:YGAQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGAQ_ECOLI pepinfo swissprot:YGAQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGAQ_ECOLI pepnet swissprot:YGAQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGAQ_ECOLI pepstats swissprot:YGAQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGAQ_ECOLI pepwheel swissprot:YGAQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGAQ_ECOLI pepwindow swissprot:YGAQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGAQ_ECOLI sigcleave swissprot:YGAQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGAQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4260429 16 # CATALYTIC ACTIVITY GATD_ECOLI Galactitol-1-phosphate + NAD(+) = L-tagatose 6-phosphate + NADH. # COFACTOR GATD_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000250}; Note=Binds 2 Zn(2+) ions per subunit. {ECO 0000250}; # EcoGene EG12417 gatD # FUNCTION GATD_ECOLI Converts galactitol 1-phosphate to tagatose 6-phosphate. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_function GO:0008868 galactitol-1-phosphate 5-dehydrogenase activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IPI:IntAct. # GO_process GO:0019404 galactitol catabolic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.720 -; 1. # Gene3D 3.90.180.10 -; 1. # INTERACTION GATD_ECOLI Self; NbExp=3; IntAct=EBI-1127517, EBI-1127517; # IntAct P0A9S3 16 # InterPro IPR002085 ADH_SF_Zn-type # InterPro IPR002328 ADH_Zn_CS # InterPro IPR011032 GroES-like # InterPro IPR013149 ADH_C # InterPro IPR013154 ADH_N # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR020843 PKS_ER # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00052 Galactose metabolism # Organism GATD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11695 PTHR11695 # PATRIC 32119515 VBIEscCol129921_2168 # PDB 4A2C X-ray; 1.87 A; A/B=1-346 # PDB 4UEJ X-ray; 1.74 A; A/B=1-346 # PDB 4UEK X-ray; 1.90 A; A/B=1-346 # PDB 4UEO X-ray; 2.00 A; A/B=1-346 # PIR B64976 B64976 # PROSITE PS00059 ADH_ZINC # Pfam PF00107 ADH_zinc_N # Pfam PF08240 ADH_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GATD_ECOLI Galactitol-1-phosphate 5-dehydrogenase # RefSeq NP_416594 NC_000913.3 # RefSeq WP_000844219 NZ_LN832404.1 # SIMILARITY Belongs to the zinc-containing alcohol dehydrogenase family. {ECO 0000305}. # SMART SM00829 PKS_ER # SUPFAM SSF50129 SSF50129 # SUPFAM SSF51735 SSF51735 # eggNOG COG1063 LUCA # eggNOG ENOG4107WTH Bacteria BLAST swissprot:GATD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GATD_ECOLI BioCyc ECOL316407:JW2075-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2075-MONOMER BioCyc EcoCyc:GALACTITOLPDEHYD-MONOMER http://biocyc.org/getid?id=EcoCyc:GALACTITOLPDEHYD-MONOMER BioCyc MetaCyc:GALACTITOLPDEHYD-MONOMER http://biocyc.org/getid?id=MetaCyc:GALACTITOLPDEHYD-MONOMER COG COG1063 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1063 DIP DIP-47890N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47890N DOI 10.1016/0167-4781(95)00053-J http://dx.doi.org/10.1016/0167-4781(95)00053-J DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.251 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.251 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X79837 http://www.ebi.ac.uk/ena/data/view/X79837 ENZYME 1.1.1.251 http://enzyme.expasy.org/EC/1.1.1.251 EchoBASE EB2316 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2316 EcoGene EG12417 http://www.ecogene.org/geneInfo.php?eg_id=EG12417 EnsemblBacteria AAC75152 http://www.ensemblgenomes.org/id/AAC75152 EnsemblBacteria AAC75152 http://www.ensemblgenomes.org/id/AAC75152 EnsemblBacteria BAA15954 http://www.ensemblgenomes.org/id/BAA15954 EnsemblBacteria BAA15954 http://www.ensemblgenomes.org/id/BAA15954 EnsemblBacteria BAA15954 http://www.ensemblgenomes.org/id/BAA15954 EnsemblBacteria b2091 http://www.ensemblgenomes.org/id/b2091 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0008868 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008868 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0019404 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019404 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 Gene3D 3.90.180.10 http://www.cathdb.info/version/latest/superfamily/3.90.180.10 GeneID 946598 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946598 HOGENOM HOG000294670 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000294670&db=HOGENOM6 InParanoid P0A9S3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9S3 IntAct P0A9S3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9S3* IntEnz 1.1.1.251 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.251 InterPro IPR002085 http://www.ebi.ac.uk/interpro/entry/IPR002085 InterPro IPR002328 http://www.ebi.ac.uk/interpro/entry/IPR002328 InterPro IPR011032 http://www.ebi.ac.uk/interpro/entry/IPR011032 InterPro IPR013149 http://www.ebi.ac.uk/interpro/entry/IPR013149 InterPro IPR013154 http://www.ebi.ac.uk/interpro/entry/IPR013154 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR020843 http://www.ebi.ac.uk/interpro/entry/IPR020843 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2075 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2075 KEGG_Gene eco:b2091 http://www.genome.jp/dbget-bin/www_bget?eco:b2091 KEGG_Orthology KO:K00094 http://www.genome.jp/dbget-bin/www_bget?KO:K00094 KEGG_Pathway ko00052 http://www.genome.jp/kegg-bin/show_pathway?ko00052 KEGG_Reaction rn:R05571 http://www.genome.jp/dbget-bin/www_bget?rn:R05571 MINT MINT-8389742 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8389742 OMA TSINFAG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TSINFAG PANTHER PTHR11695 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11695 PDB 4A2C http://www.ebi.ac.uk/pdbe-srv/view/entry/4A2C PDB 4UEJ http://www.ebi.ac.uk/pdbe-srv/view/entry/4UEJ PDB 4UEK http://www.ebi.ac.uk/pdbe-srv/view/entry/4UEK PDB 4UEO http://www.ebi.ac.uk/pdbe-srv/view/entry/4UEO PDBsum 4A2C http://www.ebi.ac.uk/pdbsum/4A2C PDBsum 4UEJ http://www.ebi.ac.uk/pdbsum/4UEJ PDBsum 4UEK http://www.ebi.ac.uk/pdbsum/4UEK PDBsum 4UEO http://www.ebi.ac.uk/pdbsum/4UEO PROSITE PS00059 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00059 PSORT swissprot:GATD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GATD_ECOLI PSORT-B swissprot:GATD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GATD_ECOLI PSORT2 swissprot:GATD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GATD_ECOLI Pfam PF00107 http://pfam.xfam.org/family/PF00107 Pfam PF08240 http://pfam.xfam.org/family/PF08240 Phobius swissprot:GATD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GATD_ECOLI PhylomeDB P0A9S3 http://phylomedb.org/?seqid=P0A9S3 ProteinModelPortal P0A9S3 http://www.proteinmodelportal.org/query/uniprot/P0A9S3 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7772602 http://www.ncbi.nlm.nih.gov/pubmed/7772602 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416594 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416594 RefSeq WP_000844219 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000844219 SMART SM00829 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00829 SMR P0A9S3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9S3 STRING 511145.b2091 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2091&targetmode=cogs STRING COG1063 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1063&targetmode=cogs SUPFAM SSF50129 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50129 SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB GATD_ECOLI http://www.uniprot.org/uniprot/GATD_ECOLI UniProtKB-AC P0A9S3 http://www.uniprot.org/uniprot/P0A9S3 charge swissprot:GATD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GATD_ECOLI eggNOG COG1063 http://eggnogapi.embl.de/nog_data/html/tree/COG1063 eggNOG ENOG4107WTH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107WTH epestfind swissprot:GATD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GATD_ECOLI garnier swissprot:GATD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GATD_ECOLI helixturnhelix swissprot:GATD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GATD_ECOLI hmoment swissprot:GATD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GATD_ECOLI iep swissprot:GATD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GATD_ECOLI inforesidue swissprot:GATD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GATD_ECOLI octanol swissprot:GATD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GATD_ECOLI pepcoil swissprot:GATD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GATD_ECOLI pepdigest swissprot:GATD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GATD_ECOLI pepinfo swissprot:GATD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GATD_ECOLI pepnet swissprot:GATD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GATD_ECOLI pepstats swissprot:GATD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GATD_ECOLI pepwheel swissprot:GATD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GATD_ECOLI pepwindow swissprot:GATD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GATD_ECOLI sigcleave swissprot:GATD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GATD_ECOLI ## Database ID URL or Descriptions # BioGrid 4260250 11 # EcoGene EG13827 ydfO # Gene3D 3.30.1810.10 -; 1. # InterPro IPR009833 DUF1398 # Organism YDFO_ECOLI Escherichia coli (strain K12) # PATRIC 32118402 VBIEscCol129921_1621 # PDB 2HH8 NMR; -; A=1-133 # PIR H64909 H64909 # Pfam PF07166 DUF1398 # ProDom PD021249 DUF1398 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDFO_ECOLI Uncharacterized protein YdfO # RefSeq NP_416067 NC_000913.3 # RefSeq WP_000373090 NZ_LN832404.1 # SIMILARITY To E.coli YbcV and YcgX. {ECO 0000305}. # SUPFAM SSF160419 SSF160419 # eggNOG COG5562 LUCA # eggNOG ENOG41064WM Bacteria BLAST swissprot:YDFO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDFO_ECOLI BioCyc ECOL316407:JW5252-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5252-MONOMER BioCyc EcoCyc:G6822-MONOMER http://biocyc.org/getid?id=EcoCyc:G6822-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3588 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3588 EcoGene EG13827 http://www.ecogene.org/geneInfo.php?eg_id=EG13827 EnsemblBacteria AAC74622 http://www.ensemblgenomes.org/id/AAC74622 EnsemblBacteria AAC74622 http://www.ensemblgenomes.org/id/AAC74622 EnsemblBacteria BAE76466 http://www.ensemblgenomes.org/id/BAE76466 EnsemblBacteria BAE76466 http://www.ensemblgenomes.org/id/BAE76466 EnsemblBacteria BAE76466 http://www.ensemblgenomes.org/id/BAE76466 EnsemblBacteria b1549 http://www.ensemblgenomes.org/id/b1549 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.30.1810.10 http://www.cathdb.info/version/latest/superfamily/3.30.1810.10 GeneID 945992 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945992 HOGENOM HOG000119635 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000119635&db=HOGENOM6 InterPro IPR009833 http://www.ebi.ac.uk/interpro/entry/IPR009833 KEGG_Gene ecj:JW5252 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5252 KEGG_Gene eco:b1549 http://www.genome.jp/dbget-bin/www_bget?eco:b1549 OMA PIREMEM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PIREMEM PDB 2HH8 http://www.ebi.ac.uk/pdbe-srv/view/entry/2HH8 PDBsum 2HH8 http://www.ebi.ac.uk/pdbsum/2HH8 PSORT swissprot:YDFO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDFO_ECOLI PSORT-B swissprot:YDFO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDFO_ECOLI PSORT2 swissprot:YDFO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDFO_ECOLI Pfam PF07166 http://pfam.xfam.org/family/PF07166 Phobius swissprot:YDFO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDFO_ECOLI PhylomeDB P76156 http://phylomedb.org/?seqid=P76156 ProteinModelPortal P76156 http://www.proteinmodelportal.org/query/uniprot/P76156 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416067 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416067 RefSeq WP_000373090 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000373090 SMR P76156 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76156 STRING 511145.b1549 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1549&targetmode=cogs SUPFAM SSF160419 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF160419 UniProtKB YDFO_ECOLI http://www.uniprot.org/uniprot/YDFO_ECOLI UniProtKB-AC P76156 http://www.uniprot.org/uniprot/P76156 charge swissprot:YDFO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDFO_ECOLI eggNOG COG5562 http://eggnogapi.embl.de/nog_data/html/tree/COG5562 eggNOG ENOG41064WM http://eggnogapi.embl.de/nog_data/html/tree/ENOG41064WM epestfind swissprot:YDFO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDFO_ECOLI garnier swissprot:YDFO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDFO_ECOLI helixturnhelix swissprot:YDFO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDFO_ECOLI hmoment swissprot:YDFO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDFO_ECOLI iep swissprot:YDFO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDFO_ECOLI inforesidue swissprot:YDFO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDFO_ECOLI octanol swissprot:YDFO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDFO_ECOLI pepcoil swissprot:YDFO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDFO_ECOLI pepdigest swissprot:YDFO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDFO_ECOLI pepinfo swissprot:YDFO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDFO_ECOLI pepnet swissprot:YDFO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDFO_ECOLI pepstats swissprot:YDFO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDFO_ECOLI pepwheel swissprot:YDFO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDFO_ECOLI pepwindow swissprot:YDFO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDFO_ECOLI sigcleave swissprot:YDFO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDFO_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES DCYD_ECOLI pH dependence Optimum pH is 9.0. {ECO 0000269|PubMed 3908101}; Temperature dependence Optimum temperature is 45 degrees Celsius. {ECO 0000269|PubMed 3908101}; # BioGrid 4260752 8 # CATALYTIC ACTIVITY DCYD_ECOLI D-cysteine + H(2)O = H(2)S + NH(3) + pyruvate. {ECO 0000255|HAMAP-Rule MF_01045, ECO 0000269|PubMed 3908101}. # COFACTOR DCYD_ECOLI Name=pyridoxal 5'-phosphate; Xref=ChEBI CHEBI 597326; Evidence={ECO 0000255|HAMAP-Rule MF_01045, ECO 0000269|PubMed 3908101}; # EcoGene EG14038 dcyD # FUNCTION DCYD_ECOLI Catalyzes the alpha,beta-elimination reaction of D- cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine. Can also catalyze the degradation of 3-chloro-D-alanine. {ECO 0000255|HAMAP- Rule MF_01045, ECO 0000269|PubMed 3908101}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0019148 D-cysteine desulfhydrase activity; IDA:EcoliWiki. # GO_function GO:0019149 3-chloro-D-alanine dehydrochlorinase activity; IDA:EcoCyc. # GO_function GO:0030170 pyridoxal phosphate binding; IDA:EcoCyc. # GO_process GO:0006790 sulfur compound metabolic process; IDA:EcoliWiki. # GO_process GO:0006791 sulfur utilization; IMP:EcoCyc. # GO_process GO:0010438 cellular response to sulfur starvation; IEP:EcoCyc. # GO_process GO:0019447 D-cysteine catabolic process; IMP:EcoCyc. # GO_process GO:0046416 D-amino acid metabolic process; IDA:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # HAMAP MF_01045 D_Cys_desulfhydr # INDUCTION By sulfate starvation. {ECO:0000269|PubMed 11527960}. # IntAct P76316 9 # InterPro IPR001926 TrpB-like_PLP-dep # InterPro IPR005966 D-Cys_desShydrase # InterPro IPR023702 D_Cys_desulphydr_bac # InterPro IPR027278 ACCD_DCysDesulf # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00270 Cysteine and methionine metabolism # Organism DCYD_ECOLI Escherichia coli (strain K12) # PATRIC 32119173 VBIEscCol129921_2001 # PIR D64955 D64955 # PIRSF PIRSF006278 ACCD_DCysDesulf # Pfam PF00291 PALP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName D-cysteine desulfhydrase {ECO:0000255|HAMAP-Rule MF_01045} # RefSeq NP_416429 NC_000913.3 # RefSeq WP_001128215 NZ_LN832404.1 # SIMILARITY Belongs to the ACC deaminase/D-cysteine desulfhydrase family. {ECO:0000255|HAMAP-Rule MF_01045}. # SUBUNIT Homodimer. {ECO:0000305|PubMed 3908101}. # SUPFAM SSF53686 SSF53686 # TIGRFAMs TIGR01275 ACC_deam_rel # eggNOG COG2515 LUCA # eggNOG ENOG4105K6H Bacteria BLAST swissprot:DCYD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DCYD_ECOLI BioCyc ECOL316407:JW5313-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5313-MONOMER BioCyc EcoCyc:DCYSDESULF-MONOMER http://biocyc.org/getid?id=EcoCyc:DCYSDESULF-MONOMER BioCyc MetaCyc:DCYSDESULF-MONOMER http://biocyc.org/getid?id=MetaCyc:DCYSDESULF-MONOMER COG COG2515 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2515 DIP DIP-11847N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11847N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M102375200 http://dx.doi.org/10.1074/jbc.M102375200 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1111/j.1432-1033.1985.tb09335.x http://dx.doi.org/10.1111/j.1432-1033.1985.tb09335.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.4.1.15 {ECO:0000255|HAMAP-Rule:MF_01045} http://www.genome.jp/dbget-bin/www_bget?EC:4.4.1.15 {ECO:0000255|HAMAP-Rule:MF_01045} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 4.4.1.15 {ECO:0000255|HAMAP-Rule:MF_01045} http://enzyme.expasy.org/EC/4.4.1.15 {ECO:0000255|HAMAP-Rule:MF_01045} EchoBASE EB3792 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3792 EcoGene EG14038 http://www.ecogene.org/geneInfo.php?eg_id=EG14038 EnsemblBacteria AAC74986 http://www.ensemblgenomes.org/id/AAC74986 EnsemblBacteria AAC74986 http://www.ensemblgenomes.org/id/AAC74986 EnsemblBacteria BAA15739 http://www.ensemblgenomes.org/id/BAA15739 EnsemblBacteria BAA15739 http://www.ensemblgenomes.org/id/BAA15739 EnsemblBacteria BAA15739 http://www.ensemblgenomes.org/id/BAA15739 EnsemblBacteria b1919 http://www.ensemblgenomes.org/id/b1919 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0019148 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019148 GO_function GO:0019149 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019149 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GO_process GO:0006791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006791 GO_process GO:0010438 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010438 GO_process GO:0019447 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019447 GO_process GO:0046416 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046416 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GeneID 946831 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946831 HAMAP MF_01045 http://hamap.expasy.org/unirule/MF_01045 HOGENOM HOG000022459 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000022459&db=HOGENOM6 InParanoid P76316 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76316 IntAct P76316 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76316* IntEnz 4.4.1.15 {ECO:0000255|HAMAP-Rule:MF_01045} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.4.1.15 {ECO:0000255|HAMAP-Rule:MF_01045} InterPro IPR001926 http://www.ebi.ac.uk/interpro/entry/IPR001926 InterPro IPR005966 http://www.ebi.ac.uk/interpro/entry/IPR005966 InterPro IPR023702 http://www.ebi.ac.uk/interpro/entry/IPR023702 InterPro IPR027278 http://www.ebi.ac.uk/interpro/entry/IPR027278 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5313 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5313 KEGG_Gene eco:b1919 http://www.genome.jp/dbget-bin/www_bget?eco:b1919 KEGG_Orthology KO:K05396 http://www.genome.jp/dbget-bin/www_bget?KO:K05396 KEGG_Pathway ko00270 http://www.genome.jp/kegg-bin/show_pathway?ko00270 KEGG_Reaction rn:R01874 http://www.genome.jp/dbget-bin/www_bget?rn:R01874 OMA TLWDDYF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TLWDDYF PSORT swissprot:DCYD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DCYD_ECOLI PSORT-B swissprot:DCYD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DCYD_ECOLI PSORT2 swissprot:DCYD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DCYD_ECOLI Pfam PF00291 http://pfam.xfam.org/family/PF00291 Phobius swissprot:DCYD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DCYD_ECOLI PhylomeDB P76316 http://phylomedb.org/?seqid=P76316 ProteinModelPortal P76316 http://www.proteinmodelportal.org/query/uniprot/P76316 PubMed 11527960 http://www.ncbi.nlm.nih.gov/pubmed/11527960 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3908101 http://www.ncbi.nlm.nih.gov/pubmed/3908101 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416429 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416429 RefSeq WP_001128215 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001128215 SMR P76316 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76316 STRING 511145.b1919 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1919&targetmode=cogs STRING COG2515 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2515&targetmode=cogs SUPFAM SSF53686 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53686 TIGRFAMs TIGR01275 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01275 UniProtKB DCYD_ECOLI http://www.uniprot.org/uniprot/DCYD_ECOLI UniProtKB-AC P76316 http://www.uniprot.org/uniprot/P76316 charge swissprot:DCYD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DCYD_ECOLI eggNOG COG2515 http://eggnogapi.embl.de/nog_data/html/tree/COG2515 eggNOG ENOG4105K6H http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K6H epestfind swissprot:DCYD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DCYD_ECOLI garnier swissprot:DCYD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DCYD_ECOLI helixturnhelix swissprot:DCYD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DCYD_ECOLI hmoment swissprot:DCYD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DCYD_ECOLI iep swissprot:DCYD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DCYD_ECOLI inforesidue swissprot:DCYD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DCYD_ECOLI octanol swissprot:DCYD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DCYD_ECOLI pepcoil swissprot:DCYD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DCYD_ECOLI pepdigest swissprot:DCYD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DCYD_ECOLI pepinfo swissprot:DCYD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DCYD_ECOLI pepnet swissprot:DCYD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DCYD_ECOLI pepstats swissprot:DCYD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DCYD_ECOLI pepwheel swissprot:DCYD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DCYD_ECOLI pepwindow swissprot:DCYD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DCYD_ECOLI sigcleave swissprot:DCYD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DCYD_ECOLI ## Database ID URL or Descriptions # BioGrid 4259545 94 # EcoGene EG13484 ydjH # GO_function GO:0004747 ribokinase activity; IEA:InterPro. # GO_process GO:0006014 D-ribose metabolic process; IEA:InterPro. # GOslim_function GO:0016301 kinase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.1190.20 -; 1. # IntAct P77493 2 # InterPro IPR002139 Ribo/fructo_kinase # InterPro IPR002173 Carboh/pur_kinase_PfkB_CS # InterPro IPR011611 PfkB_dom # InterPro IPR029056 Ribokinase-like # Organism YDJH_ECOLI Escherichia coli (strain K12) # PATRIC 32118855 VBIEscCol129921_1845 # PDB 3H49 X-ray; 1.80 A; A/B=2-315 # PDB 3IN1 X-ray; 2.15 A; A/B=2-315 # PIR D64937 D64937 # PRINTS PR00990 RIBOKINASE # PROSITE PS00583 PFKB_KINASES_1 # PROSITE PS00584 PFKB_KINASES_2 # Pfam PF00294 PfkB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDJH_ECOLI Uncharacterized sugar kinase YdjH # RefSeq NP_416286 NC_000913.3 # RefSeq WP_000369231 NZ_LN832404.1 # SIMILARITY Belongs to the carbohydrate kinase PfkB family. {ECO 0000305}. # SUPFAM SSF53613 SSF53613 # eggNOG COG0524 LUCA # eggNOG ENOG4107UH8 Bacteria BLAST swissprot:YDJH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDJH_ECOLI BioCyc ECOL316407:JW5289-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5289-MONOMER BioCyc EcoCyc:G6959-MONOMER http://biocyc.org/getid?id=EcoCyc:G6959-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.- http://enzyme.expasy.org/EC/2.7.1.- EchoBASE EB3257 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3257 EcoGene EG13484 http://www.ecogene.org/geneInfo.php?eg_id=EG13484 EnsemblBacteria AAC74842 http://www.ensemblgenomes.org/id/AAC74842 EnsemblBacteria AAC74842 http://www.ensemblgenomes.org/id/AAC74842 EnsemblBacteria BAA15563 http://www.ensemblgenomes.org/id/BAA15563 EnsemblBacteria BAA15563 http://www.ensemblgenomes.org/id/BAA15563 EnsemblBacteria BAA15563 http://www.ensemblgenomes.org/id/BAA15563 EnsemblBacteria b1772 http://www.ensemblgenomes.org/id/b1772 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004747 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004747 GO_process GO:0006014 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006014 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.1190.20 http://www.cathdb.info/version/latest/superfamily/3.40.1190.20 GeneID 946285 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946285 HOGENOM HOG000121120 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000121120&db=HOGENOM6 InParanoid P77493 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77493 IntAct P77493 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77493* IntEnz 2.7.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1 InterPro IPR002139 http://www.ebi.ac.uk/interpro/entry/IPR002139 InterPro IPR002173 http://www.ebi.ac.uk/interpro/entry/IPR002173 InterPro IPR011611 http://www.ebi.ac.uk/interpro/entry/IPR011611 InterPro IPR029056 http://www.ebi.ac.uk/interpro/entry/IPR029056 KEGG_Gene ecj:JW5289 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5289 KEGG_Gene eco:b1772 http://www.genome.jp/dbget-bin/www_bget?eco:b1772 OMA LIICADM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LIICADM PDB 3H49 http://www.ebi.ac.uk/pdbe-srv/view/entry/3H49 PDB 3IN1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3IN1 PDBsum 3H49 http://www.ebi.ac.uk/pdbsum/3H49 PDBsum 3IN1 http://www.ebi.ac.uk/pdbsum/3IN1 PRINTS PR00990 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00990 PROSITE PS00583 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00583 PROSITE PS00584 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00584 PSORT swissprot:YDJH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDJH_ECOLI PSORT-B swissprot:YDJH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDJH_ECOLI PSORT2 swissprot:YDJH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDJH_ECOLI Pfam PF00294 http://pfam.xfam.org/family/PF00294 Phobius swissprot:YDJH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDJH_ECOLI PhylomeDB P77493 http://phylomedb.org/?seqid=P77493 ProteinModelPortal P77493 http://www.proteinmodelportal.org/query/uniprot/P77493 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416286 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416286 RefSeq WP_000369231 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000369231 SMR P77493 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77493 STRING 511145.b1772 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1772&targetmode=cogs SUPFAM SSF53613 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53613 UniProtKB YDJH_ECOLI http://www.uniprot.org/uniprot/YDJH_ECOLI UniProtKB-AC P77493 http://www.uniprot.org/uniprot/P77493 charge swissprot:YDJH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDJH_ECOLI eggNOG COG0524 http://eggnogapi.embl.de/nog_data/html/tree/COG0524 eggNOG ENOG4107UH8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107UH8 epestfind swissprot:YDJH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDJH_ECOLI garnier swissprot:YDJH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDJH_ECOLI helixturnhelix swissprot:YDJH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDJH_ECOLI hmoment swissprot:YDJH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDJH_ECOLI iep swissprot:YDJH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDJH_ECOLI inforesidue swissprot:YDJH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDJH_ECOLI octanol swissprot:YDJH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDJH_ECOLI pepcoil swissprot:YDJH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDJH_ECOLI pepdigest swissprot:YDJH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDJH_ECOLI pepinfo swissprot:YDJH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDJH_ECOLI pepnet swissprot:YDJH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDJH_ECOLI pepstats swissprot:YDJH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDJH_ECOLI pepwheel swissprot:YDJH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDJH_ECOLI pepwindow swissprot:YDJH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDJH_ECOLI sigcleave swissprot:YDJH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDJH_ECOLI ## Database ID URL or Descriptions # BioGrid 4259975 3 # EcoGene EG13321 opgE # FUNCTION OPGE_ECOLI Catalyzes the addition of a phosphoethanolamine moiety to the osmoregulated periplasmic glucan (OPG) backbone. {ECO 0000269|PubMed 24228245}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0008484 sulfuric ester hydrolase activity; IEA:InterPro. # GO_function GO:0016776 phosphotransferase activity, phosphate group as acceptor; IBA:GO_Central. # GO_process GO:0009244 lipopolysaccharide core region biosynthetic process; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.720.10 -; 1. # IntAct P75785 3 # InterPro IPR000917 Sulfatase_N # InterPro IPR017849 Alkaline_Pase-like_a/b/a # InterPro IPR017850 Alkaline_phosphatase_core # Organism OPGE_ECOLI Escherichia coli (strain K12) # PATHWAY Glycan metabolism; osmoregulated periplasmic glucan (OPG) biosynthesis. {ECO:0000269|PubMed 24228245}. # PATRIC 32116833 VBIEscCol129921_0842 # PIR G64818 G64818 # Pfam PF00884 Sulfatase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName OPGE_ECOLI Phosphoethanolamine transferase OpgE # RefSeq NP_415336 NC_000913.3 # RefSeq WP_001054678 NZ_LN832404.1 # SIMILARITY Belongs to the phosphoethanolamine transferase family. {ECO 0000305}. # SUBCELLULAR LOCATION OPGE_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # SUPFAM SSF53649 SSF53649 # eggNOG COG2194 LUCA # eggNOG ENOG4108I6E Bacteria BLAST swissprot:OPGE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:OPGE_ECOLI BioCyc ECOL316407:JW0800-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0800-MONOMER BioCyc EcoCyc:G6418-MONOMER http://biocyc.org/getid?id=EcoCyc:G6418-MONOMER BioCyc MetaCyc:G6418-MONOMER http://biocyc.org/getid?id=MetaCyc:G6418-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1155/2013/371429 http://dx.doi.org/10.1155/2013/371429 EC_number EC:2.7.-.- http://www.genome.jp/dbget-bin/www_bget?EC:2.7.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.-.- http://enzyme.expasy.org/EC/2.7.-.- EchoBASE EB3105 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3105 EcoGene EG13321 http://www.ecogene.org/geneInfo.php?eg_id=EG13321 EnsemblBacteria AAC73902 http://www.ensemblgenomes.org/id/AAC73902 EnsemblBacteria AAC73902 http://www.ensemblgenomes.org/id/AAC73902 EnsemblBacteria BAA35487 http://www.ensemblgenomes.org/id/BAA35487 EnsemblBacteria BAA35487 http://www.ensemblgenomes.org/id/BAA35487 EnsemblBacteria BAA35487 http://www.ensemblgenomes.org/id/BAA35487 EnsemblBacteria b0815 http://www.ensemblgenomes.org/id/b0815 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008484 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008484 GO_function GO:0016776 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016776 GO_process GO:0009244 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009244 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.720.10 http://www.cathdb.info/version/latest/superfamily/3.40.720.10 GeneID 945360 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945360 HOGENOM HOG000118161 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118161&db=HOGENOM6 IntAct P75785 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75785* IntEnz 2.7 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7 InterPro IPR000917 http://www.ebi.ac.uk/interpro/entry/IPR000917 InterPro IPR017849 http://www.ebi.ac.uk/interpro/entry/IPR017849 InterPro IPR017850 http://www.ebi.ac.uk/interpro/entry/IPR017850 KEGG_Gene ecj:JW0800 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0800 KEGG_Gene eco:b0815 http://www.genome.jp/dbget-bin/www_bget?eco:b0815 OMA RWGKMET http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RWGKMET PSORT swissprot:OPGE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:OPGE_ECOLI PSORT-B swissprot:OPGE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:OPGE_ECOLI PSORT2 swissprot:OPGE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:OPGE_ECOLI Pfam PF00884 http://pfam.xfam.org/family/PF00884 Phobius swissprot:OPGE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:OPGE_ECOLI PhylomeDB P75785 http://phylomedb.org/?seqid=P75785 ProteinModelPortal P75785 http://www.proteinmodelportal.org/query/uniprot/P75785 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 24228245 http://www.ncbi.nlm.nih.gov/pubmed/24228245 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415336 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415336 RefSeq WP_001054678 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001054678 SMR P75785 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75785 STRING 511145.b0815 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0815&targetmode=cogs SUPFAM SSF53649 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53649 UniProtKB OPGE_ECOLI http://www.uniprot.org/uniprot/OPGE_ECOLI UniProtKB-AC P75785 http://www.uniprot.org/uniprot/P75785 charge swissprot:OPGE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:OPGE_ECOLI eggNOG COG2194 http://eggnogapi.embl.de/nog_data/html/tree/COG2194 eggNOG ENOG4108I6E http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108I6E epestfind swissprot:OPGE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:OPGE_ECOLI garnier swissprot:OPGE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:OPGE_ECOLI helixturnhelix swissprot:OPGE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:OPGE_ECOLI hmoment swissprot:OPGE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:OPGE_ECOLI iep swissprot:OPGE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:OPGE_ECOLI inforesidue swissprot:OPGE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:OPGE_ECOLI octanol swissprot:OPGE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:OPGE_ECOLI pepcoil swissprot:OPGE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:OPGE_ECOLI pepdigest swissprot:OPGE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:OPGE_ECOLI pepinfo swissprot:OPGE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:OPGE_ECOLI pepnet swissprot:OPGE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:OPGE_ECOLI pepstats swissprot:OPGE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:OPGE_ECOLI pepwheel swissprot:OPGE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:OPGE_ECOLI pepwindow swissprot:OPGE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:OPGE_ECOLI sigcleave swissprot:OPGE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:OPGE_ECOLI ## Database ID URL or Descriptions # BioGrid 4259864 4 # EcoGene EG13617 ybbV # Organism YBBV_ECOLI Escherichia coli (strain K12) # PIR E64782 E64782 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBBV_ECOLI Uncharacterized protein YbbV BLAST swissprot:YBBV_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBBV_ECOLI BioCyc ECOL316407:JW0498-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0498-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG13617 http://www.ecogene.org/geneInfo.php?eg_id=EG13617 EnsemblBacteria BAE76288 http://www.ensemblgenomes.org/id/BAE76288 EnsemblBacteria BAE76288 http://www.ensemblgenomes.org/id/BAE76288 EnsemblBacteria BAE76288 http://www.ensemblgenomes.org/id/BAE76288 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv IntAct P75711 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75711* KEGG_Gene ecj:JW0498 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0498 PSORT swissprot:YBBV_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBBV_ECOLI PSORT-B swissprot:YBBV_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBBV_ECOLI PSORT2 swissprot:YBBV_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBBV_ECOLI Phobius swissprot:YBBV_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBBV_ECOLI ProteinModelPortal P75711 http://www.proteinmodelportal.org/query/uniprot/P75711 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 STRING 316407.85674648 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85674648&targetmode=cogs UniProtKB YBBV_ECOLI http://www.uniprot.org/uniprot/YBBV_ECOLI UniProtKB-AC P75711 http://www.uniprot.org/uniprot/P75711 charge swissprot:YBBV_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBBV_ECOLI epestfind swissprot:YBBV_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBBV_ECOLI garnier swissprot:YBBV_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBBV_ECOLI helixturnhelix swissprot:YBBV_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBBV_ECOLI hmoment swissprot:YBBV_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBBV_ECOLI iep swissprot:YBBV_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBBV_ECOLI inforesidue swissprot:YBBV_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBBV_ECOLI octanol swissprot:YBBV_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBBV_ECOLI pepcoil swissprot:YBBV_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBBV_ECOLI pepdigest swissprot:YBBV_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBBV_ECOLI pepinfo swissprot:YBBV_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBBV_ECOLI pepnet swissprot:YBBV_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBBV_ECOLI pepstats swissprot:YBBV_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBBV_ECOLI pepwheel swissprot:YBBV_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBBV_ECOLI pepwindow swissprot:YBBV_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBBV_ECOLI sigcleave swissprot:YBBV_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBBV_ECOLI ## Database ID URL or Descriptions # BioGrid 4263515 3 # EcoGene EG12694 ttdR # FUNCTION TTDR_ECOLI Positive regulator required for L-tartrate-dependent anaerobic growth on glycerol. Induces expression of the ttdA-ttdB- ygjE operon. {ECO 0000269|PubMed 16804186}. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IDA:EcoCyc. # GO_function GO:0043565 sequence-specific DNA binding; IBA:GO_Central. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # IntAct P45463 6 # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR005119 LysR_subst-bd # InterPro IPR011991 WHTH_DNA-bd_dom # Organism TTDR_ECOLI Escherichia coli (strain K12) # PATRIC 32121532 VBIEscCol129921_3153 # PIR B65094 B65094 # PROSITE PS50931 HTH_LYSR # Pfam PF00126 HTH_1 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TTDR_ECOLI HTH-type transcriptional activator TtdR # RefSeq NP_417532 NC_000913.3 # RefSeq WP_000935206 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lysR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00253}. # SUPFAM SSF46785 SSF46785 # eggNOG ENOG4105EJC Bacteria # eggNOG ENOG410XNQA LUCA BLAST swissprot:TTDR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TTDR_ECOLI BioCyc ECOL316407:JW3032-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3032-MONOMER BioCyc EcoCyc:EG12694-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12694-MONOMER DIP DIP-12223N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12223N DOI 10.1016/0378-1119(87)90303-9 http://dx.doi.org/10.1016/0378-1119(87)90303-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1099/00221287-139-7-1523 http://dx.doi.org/10.1099/00221287-139-7-1523 DOI 10.1099/mic.0.28753-0 http://dx.doi.org/10.1099/mic.0.28753-0 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L14781 http://www.ebi.ac.uk/ena/data/view/L14781 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28379 http://www.ebi.ac.uk/ena/data/view/U28379 EchoBASE EB2557 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2557 EcoGene EG12694 http://www.ecogene.org/geneInfo.php?eg_id=EG12694 EnsemblBacteria AAC76096 http://www.ensemblgenomes.org/id/AAC76096 EnsemblBacteria AAC76096 http://www.ensemblgenomes.org/id/AAC76096 EnsemblBacteria BAE77111 http://www.ensemblgenomes.org/id/BAE77111 EnsemblBacteria BAE77111 http://www.ensemblgenomes.org/id/BAE77111 EnsemblBacteria BAE77111 http://www.ensemblgenomes.org/id/BAE77111 EnsemblBacteria b3060 http://www.ensemblgenomes.org/id/b3060 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 947562 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947562 HOGENOM HOG000233519 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000233519&db=HOGENOM6 InParanoid P45463 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45463 IntAct P45463 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45463* InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW3032 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3032 KEGG_Gene eco:b3060 http://www.genome.jp/dbget-bin/www_bget?eco:b3060 OMA CIVDTNG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CIVDTNG PROSITE PS50931 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50931 PSORT swissprot:TTDR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TTDR_ECOLI PSORT-B swissprot:TTDR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TTDR_ECOLI PSORT2 swissprot:TTDR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TTDR_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:TTDR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TTDR_ECOLI PhylomeDB P45463 http://phylomedb.org/?seqid=P45463 ProteinModelPortal P45463 http://www.proteinmodelportal.org/query/uniprot/P45463 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16804186 http://www.ncbi.nlm.nih.gov/pubmed/16804186 PubMed 3297921 http://www.ncbi.nlm.nih.gov/pubmed/3297921 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 8371115 http://www.ncbi.nlm.nih.gov/pubmed/8371115 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417532 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417532 RefSeq WP_000935206 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000935206 SMR P45463 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45463 STRING 511145.b3060 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3060&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB TTDR_ECOLI http://www.uniprot.org/uniprot/TTDR_ECOLI UniProtKB-AC P45463 http://www.uniprot.org/uniprot/P45463 charge swissprot:TTDR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TTDR_ECOLI eggNOG ENOG4105EJC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EJC eggNOG ENOG410XNQA http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNQA epestfind swissprot:TTDR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TTDR_ECOLI garnier swissprot:TTDR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TTDR_ECOLI helixturnhelix swissprot:TTDR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TTDR_ECOLI hmoment swissprot:TTDR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TTDR_ECOLI iep swissprot:TTDR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TTDR_ECOLI inforesidue swissprot:TTDR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TTDR_ECOLI octanol swissprot:TTDR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TTDR_ECOLI pepcoil swissprot:TTDR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TTDR_ECOLI pepdigest swissprot:TTDR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TTDR_ECOLI pepinfo swissprot:TTDR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TTDR_ECOLI pepnet swissprot:TTDR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TTDR_ECOLI pepstats swissprot:TTDR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TTDR_ECOLI pepwheel swissprot:TTDR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TTDR_ECOLI pepwindow swissprot:TTDR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TTDR_ECOLI sigcleave swissprot:TTDR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TTDR_ECOLI ## Database ID URL or Descriptions # BioGrid 4262272 13 # EcoGene EG13529 yqaA # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR032816 SNARE_assoc # InterPro IPR032818 DedA # Organism YQAA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30353 PTHR30353 # PATRIC 32120772 VBIEscCol129921_2783 # PIR B65049 B65049 # Pfam PF09335 SNARE_assoc # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQAA_ECOLI Inner membrane protein YqaA # RefSeq NP_417174 NC_000913.3 # RefSeq WP_001287454 NZ_LN832404.1 # SIMILARITY To H.influenzae HI_0489. {ECO 0000305}. # SUBCELLULAR LOCATION YQAA_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG COG1238 LUCA # eggNOG ENOG4105W39 Bacteria BLAST swissprot:YQAA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQAA_ECOLI BioCyc ECOL316407:JW2664-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2664-MONOMER BioCyc EcoCyc:G7407-MONOMER http://biocyc.org/getid?id=EcoCyc:G7407-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3300 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3300 EcoGene EG13529 http://www.ecogene.org/geneInfo.php?eg_id=EG13529 EnsemblBacteria AAC75736 http://www.ensemblgenomes.org/id/AAC75736 EnsemblBacteria AAC75736 http://www.ensemblgenomes.org/id/AAC75736 EnsemblBacteria BAA16556 http://www.ensemblgenomes.org/id/BAA16556 EnsemblBacteria BAA16556 http://www.ensemblgenomes.org/id/BAA16556 EnsemblBacteria BAA16556 http://www.ensemblgenomes.org/id/BAA16556 EnsemblBacteria b2689 http://www.ensemblgenomes.org/id/b2689 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 945419 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945419 HOGENOM HOG000183101 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000183101&db=HOGENOM6 InParanoid P0ADR0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADR0 InterPro IPR032816 http://www.ebi.ac.uk/interpro/entry/IPR032816 InterPro IPR032818 http://www.ebi.ac.uk/interpro/entry/IPR032818 KEGG_Gene ecj:JW2664 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2664 KEGG_Gene eco:b2689 http://www.genome.jp/dbget-bin/www_bget?eco:b2689 OMA RYAAVAW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RYAAVAW PANTHER PTHR30353 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30353 PSORT swissprot:YQAA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQAA_ECOLI PSORT-B swissprot:YQAA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQAA_ECOLI PSORT2 swissprot:YQAA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQAA_ECOLI Pfam PF09335 http://pfam.xfam.org/family/PF09335 Phobius swissprot:YQAA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQAA_ECOLI PhylomeDB P0ADR0 http://phylomedb.org/?seqid=P0ADR0 ProteinModelPortal P0ADR0 http://www.proteinmodelportal.org/query/uniprot/P0ADR0 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417174 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417174 RefSeq WP_001287454 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001287454 STRING 511145.b2689 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2689&targetmode=cogs UniProtKB YQAA_ECOLI http://www.uniprot.org/uniprot/YQAA_ECOLI UniProtKB-AC P0ADR0 http://www.uniprot.org/uniprot/P0ADR0 charge swissprot:YQAA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQAA_ECOLI eggNOG COG1238 http://eggnogapi.embl.de/nog_data/html/tree/COG1238 eggNOG ENOG4105W39 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105W39 epestfind swissprot:YQAA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQAA_ECOLI garnier swissprot:YQAA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQAA_ECOLI helixturnhelix swissprot:YQAA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQAA_ECOLI hmoment swissprot:YQAA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQAA_ECOLI iep swissprot:YQAA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQAA_ECOLI inforesidue swissprot:YQAA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQAA_ECOLI octanol swissprot:YQAA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQAA_ECOLI pepcoil swissprot:YQAA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQAA_ECOLI pepdigest swissprot:YQAA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQAA_ECOLI pepinfo swissprot:YQAA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQAA_ECOLI pepnet swissprot:YQAA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQAA_ECOLI pepstats swissprot:YQAA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQAA_ECOLI pepwheel swissprot:YQAA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQAA_ECOLI pepwindow swissprot:YQAA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQAA_ECOLI sigcleave swissprot:YQAA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQAA_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES NUDG_ECOLI Kinetic parameters KM=0.028 mM for 5-methyl-dCTP {ECO 0000269|PubMed 11053429, ECO 0000269|PubMed 15823026}; KM=0.027 mM for 2-hydroxy-dATP {ECO 0000269|PubMed 11053429, ECO 0000269|PubMed 15823026}; KM=0.41 mM for 8-hydroxy-dGTP {ECO 0000269|PubMed 11053429, ECO 0000269|PubMed 15823026}; KM=0.99 mM for dCTP {ECO 0000269|PubMed 11053429, ECO 0000269|PubMed 15823026}; pH dependence Optimum pH is 8.5-9. {ECO 0000269|PubMed 11053429, ECO 0000269|PubMed 15823026}; # BRENDA 3.6.1.65 2026 # BioGrid 4260320 120 # CATALYTIC ACTIVITY NUDG_ECOLI CTP + H(2)O = CMP + diphosphate. {ECO 0000269|PubMed 11053429, ECO 0000269|PubMed 12509230, ECO 0000269|PubMed 15381107, ECO 0000269|PubMed 15823026}. # CATALYTIC ACTIVITY NUDG_ECOLI dCTP + H(2)O = dCMP + diphosphate. {ECO 0000269|PubMed 11053429, ECO 0000269|PubMed 12509230, ECO 0000269|PubMed 15381107, ECO 0000269|PubMed 15823026}. # COFACTOR NUDG_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 11053429, ECO 0000269|PubMed 15381107}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 11053429, ECO 0000269|PubMed 15381107}; Note=Divalent metal ions. Mg(2+) or Mn(2+). {ECO 0000269|PubMed 11053429, ECO 0000269|PubMed 15381107}; # EcoGene EG14009 nudG # FUNCTION NUDG_ECOLI Hydrolase with a preference for pyrimidine substrates. Has high activity with 5-methyl-dCTP, and much lower activity with CTP, dCTP, 5-hydroxy-dCTP, 2-hydroxy-dATP and 8-hydroxy-dGTP. {ECO 0000269|PubMed 11053429, ECO 0000269|PubMed 12509230, ECO 0000269|PubMed 15823026}. # GO_function GO:0016787 hydrolase activity; IDA:EcoCyc. # GO_process GO:0006281 DNA repair; IDA:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # Gene3D 3.90.79.10 -; 1. # IntAct P77788 3 # InterPro IPR000086 NUDIX_hydrolase_dom # InterPro IPR015797 NUDIX_hydrolase_dom-like # InterPro IPR020084 NUDIX_hydrolase_CS # InterPro IPR020476 Nudix_hydrolase # KEGG_Brite ko01000 Enzymes # Organism NUDG_ECOLI Escherichia coli (strain K12) # PATRIC 32118829 VBIEscCol129921_1832 # PDB 2RRK NMR; -; A=1-135 # PIR G64935 G64935 # PRINTS PR00502 NUDIXFAMILY # PROSITE PS00893 NUDIX_BOX # PROSITE PS51462 NUDIX # Pfam PF00293 NUDIX # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NUDG_ECOLI CTP pyrophosphohydrolase # RefSeq NP_416273 NC_000913.3 # RefSeq WP_000781888 NZ_LN832404.1 # SIMILARITY Belongs to the Nudix hydrolase family. {ECO 0000305}. # SIMILARITY Contains 1 nudix hydrolase domain. {ECO:0000255|PROSITE-ProRule PRU00794}. # SUBUNIT Monomer. {ECO:0000269|PubMed 22414689}. # SUPFAM SSF55811 SSF55811 # eggNOG COG0494 LUCA # eggNOG ENOG4105M6F Bacteria BLAST swissprot:NUDG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NUDG_ECOLI BioCyc ECOL316407:JW1748-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1748-MONOMER BioCyc EcoCyc:G6954-MONOMER http://biocyc.org/getid?id=EcoCyc:G6954-MONOMER BioCyc MetaCyc:G6954-MONOMER http://biocyc.org/getid?id=MetaCyc:G6954-MONOMER COG COG0494 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0494 DIP DIP-10376N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10376N DOI 10.1016/S1568-7864(02)00057-5 http://dx.doi.org/10.1016/S1568-7864(02)00057-5 DOI 10.1016/j.bbrc.2004.08.201 http://dx.doi.org/10.1016/j.bbrc.2004.08.201 DOI 10.1016/j.bbrc.2012.02.146 http://dx.doi.org/10.1016/j.bbrc.2012.02.146 DOI 10.1021/bi048071o http://dx.doi.org/10.1021/bi048071o DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M004100200 http://dx.doi.org/10.1074/jbc.M004100200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.1.65 {ECO:0000269|PubMed:11053429, ECO:0000269|PubMed:12509230, ECO:0000269|PubMed:15381107, ECO:0000269|PubMed:15823026} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.1.65 {ECO:0000269|PubMed:11053429, ECO:0000269|PubMed:12509230, ECO:0000269|PubMed:15381107, ECO:0000269|PubMed:15823026} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.6.1.65 {ECO:0000269|PubMed:11053429, ECO:0000269|PubMed:12509230, ECO:0000269|PubMed:15381107, ECO:0000269|PubMed:15823026} http://enzyme.expasy.org/EC/3.6.1.65 {ECO:0000269|PubMed:11053429, ECO:0000269|PubMed:12509230, ECO:0000269|PubMed:15381107, ECO:0000269|PubMed:15823026} EchoBASE EB3765 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3765 EcoGene EG14009 http://www.ecogene.org/geneInfo.php?eg_id=EG14009 EnsemblBacteria AAC74829 http://www.ensemblgenomes.org/id/AAC74829 EnsemblBacteria AAC74829 http://www.ensemblgenomes.org/id/AAC74829 EnsemblBacteria BAA15549 http://www.ensemblgenomes.org/id/BAA15549 EnsemblBacteria BAA15549 http://www.ensemblgenomes.org/id/BAA15549 EnsemblBacteria BAA15549 http://www.ensemblgenomes.org/id/BAA15549 EnsemblBacteria b1759 http://www.ensemblgenomes.org/id/b1759 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016787 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016787 GO_process GO:0006281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006281 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.90.79.10 http://www.cathdb.info/version/latest/superfamily/3.90.79.10 GeneID 946277 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946277 HOGENOM HOG000261967 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261967&db=HOGENOM6 InParanoid P77788 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77788 IntAct P77788 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77788* IntEnz 3.6.1.65 {ECO:0000269|PubMed:11053429, ECO:0000269|PubMed:12509230, ECO:0000269|PubMed:15381107, ECO:0000269|PubMed:15823026} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.1.65 {ECO:0000269|PubMed:11053429, ECO:0000269|PubMed:12509230, ECO:0000269|PubMed:15381107, ECO:0000269|PubMed:15823026} InterPro IPR000086 http://www.ebi.ac.uk/interpro/entry/IPR000086 InterPro IPR015797 http://www.ebi.ac.uk/interpro/entry/IPR015797 InterPro IPR020084 http://www.ebi.ac.uk/interpro/entry/IPR020084 InterPro IPR020476 http://www.ebi.ac.uk/interpro/entry/IPR020476 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1748 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1748 KEGG_Gene eco:b1759 http://www.genome.jp/dbget-bin/www_bget?eco:b1759 KEGG_Orthology KO:K08320 http://www.genome.jp/dbget-bin/www_bget?KO:K08320 OMA ECLKREM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ECLKREM PDB 2RRK http://www.ebi.ac.uk/pdbe-srv/view/entry/2RRK PDBsum 2RRK http://www.ebi.ac.uk/pdbsum/2RRK PRINTS PR00502 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00502 PROSITE PS00893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00893 PROSITE PS51462 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51462 PSORT swissprot:NUDG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NUDG_ECOLI PSORT-B swissprot:NUDG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NUDG_ECOLI PSORT2 swissprot:NUDG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NUDG_ECOLI Pfam PF00293 http://pfam.xfam.org/family/PF00293 Phobius swissprot:NUDG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NUDG_ECOLI PhylomeDB P77788 http://phylomedb.org/?seqid=P77788 ProteinModelPortal P77788 http://www.proteinmodelportal.org/query/uniprot/P77788 PubMed 11053429 http://www.ncbi.nlm.nih.gov/pubmed/11053429 PubMed 12509230 http://www.ncbi.nlm.nih.gov/pubmed/12509230 PubMed 15381107 http://www.ncbi.nlm.nih.gov/pubmed/15381107 PubMed 15823026 http://www.ncbi.nlm.nih.gov/pubmed/15823026 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22414689 http://www.ncbi.nlm.nih.gov/pubmed/22414689 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416273 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416273 RefSeq WP_000781888 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000781888 SMR P77788 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77788 STRING 511145.b1759 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1759&targetmode=cogs STRING COG0494 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0494&targetmode=cogs SUPFAM SSF55811 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55811 UniProtKB NUDG_ECOLI http://www.uniprot.org/uniprot/NUDG_ECOLI UniProtKB-AC P77788 http://www.uniprot.org/uniprot/P77788 charge swissprot:NUDG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NUDG_ECOLI eggNOG COG0494 http://eggnogapi.embl.de/nog_data/html/tree/COG0494 eggNOG ENOG4105M6F http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105M6F epestfind swissprot:NUDG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NUDG_ECOLI garnier swissprot:NUDG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NUDG_ECOLI helixturnhelix swissprot:NUDG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NUDG_ECOLI hmoment swissprot:NUDG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NUDG_ECOLI iep swissprot:NUDG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NUDG_ECOLI inforesidue swissprot:NUDG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NUDG_ECOLI octanol swissprot:NUDG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NUDG_ECOLI pepcoil swissprot:NUDG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NUDG_ECOLI pepdigest swissprot:NUDG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NUDG_ECOLI pepinfo swissprot:NUDG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NUDG_ECOLI pepnet swissprot:NUDG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NUDG_ECOLI pepstats swissprot:NUDG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NUDG_ECOLI pepwheel swissprot:NUDG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NUDG_ECOLI pepwindow swissprot:NUDG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NUDG_ECOLI sigcleave swissprot:NUDG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NUDG_ECOLI ## Database ID URL or Descriptions # BRENDA 1.3.5 2026 # BioGrid 4262907 6 # CATALYTIC ACTIVITY Succinate + a quinone = fumarate + a quinol. {ECO:0000305|PubMed 19710024}. # COFACTOR SDHA_ECOLI Name=FAD; Xref=ChEBI CHEBI 57692; Evidence={ECO 0000269|PubMed 12560550, ECO 0000269|PubMed 16407191, ECO 0000269|PubMed 19710024}; # ENZYME REGULATION Inhibited by oxaloacetate. {ECO:0000269|PubMed 12560550}. # EcoGene EG10931 sdhA # FUNCTION SDHA_ECOLI Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth. {ECO 0000305|PubMed 12560550, ECO 0000305|PubMed 16407191, ECO 0000305|PubMed 19710024}. # GO_component GO:0005886 plasma membrane; IDA:EcoliWiki. # GO_component GO:0045282 plasma membrane succinate dehydrogenase complex; IDA:EcoliWiki. # GO_function GO:0000104 succinate dehydrogenase activity; IMP:EcoliWiki. # GO_function GO:0008177 succinate dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC. # GO_function GO:0009055 electron carrier activity; IDA:EcoCyc. # GO_function GO:0050660 flavin adenine dinucleotide binding; IDA:EcoliWiki. # GO_process GO:0006099 tricarboxylic acid cycle; IGI:EcoliWiki. # GO_process GO:0009060 aerobic respiration; IGI:EcoliWiki. # GO_process GO:0009061 anaerobic respiration; IBA:GO_Central. # GO_process GO:0022900 electron transport chain; IEA:InterPro. # GO_process GO:0055114 oxidation-reduction process; IGI:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0008150 biological_process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.20.58.100 -; 1. # Gene3D 3.50.50.60 -; 2. # Gene3D 3.90.700.10 -; 1. # INTERACTION SDHA_ECOLI P07014 sdhB; NbExp=2; IntAct=EBI-371263, EBI-1035514; # IntAct P0AC41 91 # InterPro IPR003952 FRD_SDH_FAD_BS # InterPro IPR003953 FAD-binding_2 # InterPro IPR011281 Succ_DH_flav_su_fwd # InterPro IPR014006 Succ_Dhase_FrdA_Gneg # InterPro IPR015939 Fum_Rdtase/Succ_DH_flav-like_C # InterPro IPR023753 FAD/NAD-binding_dom # InterPro IPR027477 Succ_DH/fumarate_Rdtase_cat # InterPro IPR030664 SdhA/FrdA/AprA # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00020 Citrate cycle (TCA cycle) # KEGG_Pathway ko00190 Oxidative phosphorylation # KEGG_Pathway ko00623 Toluene degradation # KEGG_Pathway ko00650 Butanoate metabolism # KEGG_Pathway ko00720 Carbon fixation pathways in prokaryotes # KEGG_Pathway ko05134 Legionellosis # Organism SDHA_ECOLI Escherichia coli (strain K12) # PATHWAY Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (bacterial route): step 1/1. {ECO 0000305|PubMed:19710024}. # PATRIC 32116641 VBIEscCol129921_0753 # PDB 1NEK X-ray; 2.60 A; A=1-588 # PDB 1NEN X-ray; 2.90 A; A=1-588 # PDB 2ACZ X-ray; 3.10 A; A=1-588 # PDB 2AD0 Model; -; A=1-588 # PDB 2WDQ X-ray; 2.40 A; A/E/I=1-588 # PDB 2WDR X-ray; 3.20 A; A/E/I=1-588 # PDB 2WDV X-ray; 3.20 A; A/E/I=1-588 # PDB 2WP9 X-ray; 2.70 A; A/E/I=1-588 # PDB 2WS3 X-ray; 3.20 A; A/E/I=1-588 # PDB 2WU2 X-ray; 2.50 A; A/E/I=1-588 # PDB 2WU5 X-ray; 2.80 A; A/E/I=1-588 # PIR B64808 DEECSF # PIRSF PIRSF000171 SDHA_APRA_LASPO # PROSITE PS00504 FRD_SDH_FAD_BINDING # Pfam PF00890 FAD_binding_2 # Pfam PF02910 Succ_DH_flav_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SDHA_ECOLI Succinate dehydrogenase flavoprotein subunit # RefSeq NP_415251 NC_000913.3 # RefSeq WP_000775540 NZ_LN832404.1 # SIMILARITY Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION SDHA_ECOLI Cell inner membrane {ECO 0000269|PubMed 12560550, ECO 0000269|PubMed 16079137}; Peripheral membrane protein {ECO 0000269|PubMed 12560550, ECO 0000269|PubMed 16079137}; Cytoplasmic side {ECO 0000269|PubMed 12560550, ECO 0000269|PubMed 16079137}. # SUBUNIT SDHA_ECOLI Part of an enzyme complex containing four subunits a flavoprotein, an iron-sulfur, cytochrome b-556, and a hydrophobic anchor protein. The complex forms trimers. {ECO 0000269|PubMed 12560550, ECO 0000269|PubMed 16079137, ECO 0000269|PubMed 16407191, ECO 0000269|PubMed 19710024}. # SUPFAM SSF46977 SSF46977 # SUPFAM SSF51905 SSF51905; 2 # SUPFAM SSF56425 SSF56425 # TIGRFAMs TIGR01812 sdhA_frdA_Gneg # TIGRFAMs TIGR01816 sdhA_forward # UniPathway UPA00223 UER01005 # eggNOG COG1053 LUCA # eggNOG ENOG4105C00 Bacteria BLAST swissprot:SDHA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SDHA_ECOLI BioCyc ECOL316407:JW0713-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0713-MONOMER BioCyc EcoCyc:SDH-FLAVO http://biocyc.org/getid?id=EcoCyc:SDH-FLAVO BioCyc MetaCyc:SDH-FLAVO http://biocyc.org/getid?id=MetaCyc:SDH-FLAVO COG COG1053 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1053 DIP DIP-31877N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31877N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1998.1726 http://dx.doi.org/10.1006/jmbi.1998.1726 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2220519 http://dx.doi.org/10.1042/bj2220519 DOI 10.1042/bj2230507 http://dx.doi.org/10.1042/bj2230507 DOI 10.1074/jbc.M109.010058 http://dx.doi.org/10.1074/jbc.M109.010058 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1074/jbc.M508173200 http://dx.doi.org/10.1074/jbc.M508173200 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1079605 http://dx.doi.org/10.1126/science.1079605 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.3.5.1 {ECO:0000305|PubMed:19710024} http://www.genome.jp/dbget-bin/www_bget?EC:1.3.5.1 {ECO:0000305|PubMed:19710024} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01619 http://www.ebi.ac.uk/ena/data/view/J01619 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X00980 http://www.ebi.ac.uk/ena/data/view/X00980 EMBL X01070 http://www.ebi.ac.uk/ena/data/view/X01070 ENZYME 1.3.5.1 {ECO:0000305|PubMed:19710024} http://enzyme.expasy.org/EC/1.3.5.1 {ECO:0000305|PubMed:19710024} EchoBASE EB0924 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0924 EcoGene EG10931 http://www.ecogene.org/geneInfo.php?eg_id=EG10931 EnsemblBacteria AAC73817 http://www.ensemblgenomes.org/id/AAC73817 EnsemblBacteria AAC73817 http://www.ensemblgenomes.org/id/AAC73817 EnsemblBacteria BAA35390 http://www.ensemblgenomes.org/id/BAA35390 EnsemblBacteria BAA35390 http://www.ensemblgenomes.org/id/BAA35390 EnsemblBacteria BAA35390 http://www.ensemblgenomes.org/id/BAA35390 EnsemblBacteria b0723 http://www.ensemblgenomes.org/id/b0723 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0045282 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045282 GO_function GO:0000104 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000104 GO_function GO:0008177 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008177 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_process GO:0006099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006099 GO_process GO:0009060 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009060 GO_process GO:0009061 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009061 GO_process GO:0022900 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022900 GO_process GO:0055114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.20.58.100 http://www.cathdb.info/version/latest/superfamily/1.20.58.100 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 Gene3D 3.90.700.10 http://www.cathdb.info/version/latest/superfamily/3.90.700.10 GeneID 945402 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945402 HOGENOM HOG000160475 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000160475&db=HOGENOM6 InParanoid P0AC41 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AC41 IntAct P0AC41 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AC41* IntEnz 1.3.5.1 {ECO:0000305|PubMed:19710024} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.3.5.1 {ECO:0000305|PubMed:19710024} InterPro IPR003952 http://www.ebi.ac.uk/interpro/entry/IPR003952 InterPro IPR003953 http://www.ebi.ac.uk/interpro/entry/IPR003953 InterPro IPR011281 http://www.ebi.ac.uk/interpro/entry/IPR011281 InterPro IPR014006 http://www.ebi.ac.uk/interpro/entry/IPR014006 InterPro IPR015939 http://www.ebi.ac.uk/interpro/entry/IPR015939 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 InterPro IPR027477 http://www.ebi.ac.uk/interpro/entry/IPR027477 InterPro IPR030664 http://www.ebi.ac.uk/interpro/entry/IPR030664 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0713 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0713 KEGG_Gene eco:b0723 http://www.genome.jp/dbget-bin/www_bget?eco:b0723 KEGG_Orthology KO:K00239 http://www.genome.jp/dbget-bin/www_bget?KO:K00239 KEGG_Pathway ko00020 http://www.genome.jp/kegg-bin/show_pathway?ko00020 KEGG_Pathway ko00190 http://www.genome.jp/kegg-bin/show_pathway?ko00190 KEGG_Pathway ko00623 http://www.genome.jp/kegg-bin/show_pathway?ko00623 KEGG_Pathway ko00650 http://www.genome.jp/kegg-bin/show_pathway?ko00650 KEGG_Pathway ko00720 http://www.genome.jp/kegg-bin/show_pathway?ko00720 KEGG_Pathway ko05134 http://www.genome.jp/kegg-bin/show_pathway?ko05134 KEGG_Reaction rn:R00408 http://www.genome.jp/dbget-bin/www_bget?rn:R00408 KEGG_Reaction rn:R00412 http://www.genome.jp/dbget-bin/www_bget?rn:R00412 MINT MINT-6478272 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-6478272 OMA CWEEAHR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CWEEAHR PDB 1NEK http://www.ebi.ac.uk/pdbe-srv/view/entry/1NEK PDB 1NEN http://www.ebi.ac.uk/pdbe-srv/view/entry/1NEN PDB 2ACZ http://www.ebi.ac.uk/pdbe-srv/view/entry/2ACZ PDB 2AD0 http://www.ebi.ac.uk/pdbe-srv/view/entry/2AD0 PDB 2WDQ http://www.ebi.ac.uk/pdbe-srv/view/entry/2WDQ PDB 2WDR http://www.ebi.ac.uk/pdbe-srv/view/entry/2WDR PDB 2WDV http://www.ebi.ac.uk/pdbe-srv/view/entry/2WDV PDB 2WP9 http://www.ebi.ac.uk/pdbe-srv/view/entry/2WP9 PDB 2WS3 http://www.ebi.ac.uk/pdbe-srv/view/entry/2WS3 PDB 2WU2 http://www.ebi.ac.uk/pdbe-srv/view/entry/2WU2 PDB 2WU5 http://www.ebi.ac.uk/pdbe-srv/view/entry/2WU5 PDBsum 1NEK http://www.ebi.ac.uk/pdbsum/1NEK PDBsum 1NEN http://www.ebi.ac.uk/pdbsum/1NEN PDBsum 2ACZ http://www.ebi.ac.uk/pdbsum/2ACZ PDBsum 2AD0 http://www.ebi.ac.uk/pdbsum/2AD0 PDBsum 2WDQ http://www.ebi.ac.uk/pdbsum/2WDQ PDBsum 2WDR http://www.ebi.ac.uk/pdbsum/2WDR PDBsum 2WDV http://www.ebi.ac.uk/pdbsum/2WDV PDBsum 2WP9 http://www.ebi.ac.uk/pdbsum/2WP9 PDBsum 2WS3 http://www.ebi.ac.uk/pdbsum/2WS3 PDBsum 2WU2 http://www.ebi.ac.uk/pdbsum/2WU2 PDBsum 2WU5 http://www.ebi.ac.uk/pdbsum/2WU5 PROSITE PS00504 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00504 PSORT swissprot:SDHA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SDHA_ECOLI PSORT-B swissprot:SDHA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SDHA_ECOLI PSORT2 swissprot:SDHA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SDHA_ECOLI Pfam PF00890 http://pfam.xfam.org/family/PF00890 Pfam PF02910 http://pfam.xfam.org/family/PF02910 Phobius swissprot:SDHA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SDHA_ECOLI PhylomeDB P0AC41 http://phylomedb.org/?seqid=P0AC41 ProteinModelPortal P0AC41 http://www.proteinmodelportal.org/query/uniprot/P0AC41 PubMed 12560550 http://www.ncbi.nlm.nih.gov/pubmed/12560550 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16407191 http://www.ncbi.nlm.nih.gov/pubmed/16407191 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 19710024 http://www.ncbi.nlm.nih.gov/pubmed/19710024 PubMed 6383359 http://www.ncbi.nlm.nih.gov/pubmed/6383359 PubMed 6388571 http://www.ncbi.nlm.nih.gov/pubmed/6388571 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 RefSeq NP_415251 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415251 RefSeq WP_000775540 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000775540 SMR P0AC41 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AC41 STRING 511145.b0723 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0723&targetmode=cogs STRING COG1053 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1053&targetmode=cogs SUPFAM SSF46977 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46977 SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 SUPFAM SSF56425 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56425 SWISS-2DPAGE P0AC41 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AC41 TIGRFAMs TIGR01812 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01812 TIGRFAMs TIGR01816 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01816 UniProtKB SDHA_ECOLI http://www.uniprot.org/uniprot/SDHA_ECOLI UniProtKB-AC P0AC41 http://www.uniprot.org/uniprot/P0AC41 charge swissprot:SDHA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SDHA_ECOLI eggNOG COG1053 http://eggnogapi.embl.de/nog_data/html/tree/COG1053 eggNOG ENOG4105C00 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C00 epestfind swissprot:SDHA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SDHA_ECOLI garnier swissprot:SDHA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SDHA_ECOLI helixturnhelix swissprot:SDHA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SDHA_ECOLI hmoment swissprot:SDHA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SDHA_ECOLI iep swissprot:SDHA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SDHA_ECOLI inforesidue swissprot:SDHA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SDHA_ECOLI octanol swissprot:SDHA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SDHA_ECOLI pepcoil swissprot:SDHA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SDHA_ECOLI pepdigest swissprot:SDHA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SDHA_ECOLI pepinfo swissprot:SDHA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SDHA_ECOLI pepnet swissprot:SDHA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SDHA_ECOLI pepstats swissprot:SDHA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SDHA_ECOLI pepwheel swissprot:SDHA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SDHA_ECOLI pepwindow swissprot:SDHA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SDHA_ECOLI sigcleave swissprot:SDHA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SDHA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260292 16 # EcoGene EG13975 ydiP # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0000987 core promoter proximal region sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IBA:GO_Central. # GO_process GO:0006351 transcription, DNA-templated; ISS:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.60 -; 2. # Gene3D 2.60.120.10 -; 1. # InterPro IPR003313 AraC-bd # InterPro IPR009057 Homeodomain-like # InterPro IPR011051 RmlC_Cupin # InterPro IPR014710 RmlC-like_jellyroll # InterPro IPR018060 HTH_AraC # Organism YDIP_ECOLI Escherichia coli (strain K12) # PATRIC 32118698 VBIEscCol129921_1767 # PIR H64927 H64927 # PROSITE PS01124 HTH_ARAC_FAMILY_2 # Pfam PF02311 AraC_binding # Pfam PF12833 HTH_18 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDIP_ECOLI Uncharacterized HTH-type transcriptional regulator YdiP # RefSeq NP_416211 NC_000913.3 # RefSeq WP_000284799 NZ_LN832404.1 # SIMILARITY Contains 1 HTH araC/xylS-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00593}. # SMART SM00342 HTH_ARAC # SUPFAM SSF46689 SSF46689; 2 # SUPFAM SSF51182 SSF51182 # eggNOG ENOG4105W4W Bacteria # eggNOG ENOG410XVZJ LUCA BLAST swissprot:YDIP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDIP_ECOLI BioCyc ECOL316407:JW1686-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1686-MONOMER BioCyc EcoCyc:G6919-MONOMER http://biocyc.org/getid?id=EcoCyc:G6919-MONOMER DIP DIP-11757N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11757N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3732 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3732 EcoGene EG13975 http://www.ecogene.org/geneInfo.php?eg_id=EG13975 EnsemblBacteria AAC74766 http://www.ensemblgenomes.org/id/AAC74766 EnsemblBacteria AAC74766 http://www.ensemblgenomes.org/id/AAC74766 EnsemblBacteria BAA15465 http://www.ensemblgenomes.org/id/BAA15465 EnsemblBacteria BAA15465 http://www.ensemblgenomes.org/id/BAA15465 EnsemblBacteria BAA15465 http://www.ensemblgenomes.org/id/BAA15465 EnsemblBacteria b1696 http://www.ensemblgenomes.org/id/b1696 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000987 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000987 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 Gene3D 2.60.120.10 http://www.cathdb.info/version/latest/superfamily/2.60.120.10 GeneID 945095 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945095 HOGENOM HOG000120975 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120975&db=HOGENOM6 InParanoid P77402 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77402 IntAct P77402 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77402* InterPro IPR003313 http://www.ebi.ac.uk/interpro/entry/IPR003313 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR011051 http://www.ebi.ac.uk/interpro/entry/IPR011051 InterPro IPR014710 http://www.ebi.ac.uk/interpro/entry/IPR014710 InterPro IPR018060 http://www.ebi.ac.uk/interpro/entry/IPR018060 KEGG_Gene ecj:JW1686 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1686 KEGG_Gene eco:b1696 http://www.genome.jp/dbget-bin/www_bget?eco:b1696 OMA LSACESC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LSACESC PROSITE PS01124 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01124 PSORT swissprot:YDIP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDIP_ECOLI PSORT-B swissprot:YDIP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDIP_ECOLI PSORT2 swissprot:YDIP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDIP_ECOLI Pfam PF02311 http://pfam.xfam.org/family/PF02311 Pfam PF12833 http://pfam.xfam.org/family/PF12833 Phobius swissprot:YDIP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDIP_ECOLI PhylomeDB P77402 http://phylomedb.org/?seqid=P77402 ProteinModelPortal P77402 http://www.proteinmodelportal.org/query/uniprot/P77402 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416211 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416211 RefSeq WP_000284799 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000284799 SMART SM00342 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00342 SMR P77402 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77402 STRING 511145.b1696 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1696&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF51182 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51182 UniProtKB YDIP_ECOLI http://www.uniprot.org/uniprot/YDIP_ECOLI UniProtKB-AC P77402 http://www.uniprot.org/uniprot/P77402 charge swissprot:YDIP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDIP_ECOLI eggNOG ENOG4105W4W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105W4W eggNOG ENOG410XVZJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XVZJ epestfind swissprot:YDIP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDIP_ECOLI garnier swissprot:YDIP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDIP_ECOLI helixturnhelix swissprot:YDIP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDIP_ECOLI hmoment swissprot:YDIP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDIP_ECOLI iep swissprot:YDIP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDIP_ECOLI inforesidue swissprot:YDIP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDIP_ECOLI octanol swissprot:YDIP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDIP_ECOLI pepcoil swissprot:YDIP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDIP_ECOLI pepdigest swissprot:YDIP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDIP_ECOLI pepinfo swissprot:YDIP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDIP_ECOLI pepnet swissprot:YDIP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDIP_ECOLI pepstats swissprot:YDIP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDIP_ECOLI pepwheel swissprot:YDIP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDIP_ECOLI pepwindow swissprot:YDIP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDIP_ECOLI sigcleave swissprot:YDIP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDIP_ECOLI ## Database ID URL or Descriptions # BioGrid 4260707 246 # EcoGene EG11748 yadD # InterPro IPR006842 Transposase_31 # InterPro IPR010106 CHP01784 # Organism YADD_ECOLI Escherichia coli (strain K12) # PATRIC 32115369 VBIEscCol129921_0136 # PIR D64736 D64736 # Pfam PF04754 Transposase_31 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YADD_ECOLI Uncharacterized protein YadD # RefSeq NP_414674 NC_000913.3 # RefSeq WP_000339954 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA24273.1; Type=Frameshift; Positions=17; Evidence={ECO 0000305}; # SIMILARITY Belongs to the YadD/YfaD/YhgA/YjiP family. {ECO 0000305}. # TIGRFAMs TIGR01784 T_den_put_tspse # eggNOG COG5464 LUCA # eggNOG ENOG4108A32 Bacteria BLAST swissprot:YADD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YADD_ECOLI BioCyc ECOL316407:JW5010-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5010-MONOMER BioCyc EcoCyc:EG11748-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11748-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L17086 http://www.ebi.ac.uk/ena/data/view/L17086 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1698 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1698 EcoGene EG11748 http://www.ecogene.org/geneInfo.php?eg_id=EG11748 EnsemblBacteria AAC73243 http://www.ensemblgenomes.org/id/AAC73243 EnsemblBacteria AAC73243 http://www.ensemblgenomes.org/id/AAC73243 EnsemblBacteria BAB96710 http://www.ensemblgenomes.org/id/BAB96710 EnsemblBacteria BAB96710 http://www.ensemblgenomes.org/id/BAB96710 EnsemblBacteria BAB96710 http://www.ensemblgenomes.org/id/BAB96710 EnsemblBacteria b0132 http://www.ensemblgenomes.org/id/b0132 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 944781 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944781 HOGENOM HOG000116866 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000116866&db=HOGENOM6 InParanoid P31665 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31665 InterPro IPR006842 http://www.ebi.ac.uk/interpro/entry/IPR006842 InterPro IPR010106 http://www.ebi.ac.uk/interpro/entry/IPR010106 KEGG_Gene ecj:JW5010 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5010 KEGG_Gene eco:b0132 http://www.genome.jp/dbget-bin/www_bget?eco:b0132 OMA RVYNNPF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RVYNNPF PSORT swissprot:YADD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YADD_ECOLI PSORT-B swissprot:YADD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YADD_ECOLI PSORT2 swissprot:YADD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YADD_ECOLI Pfam PF04754 http://pfam.xfam.org/family/PF04754 Phobius swissprot:YADD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YADD_ECOLI PhylomeDB P31665 http://phylomedb.org/?seqid=P31665 ProteinModelPortal P31665 http://www.proteinmodelportal.org/query/uniprot/P31665 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414674 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414674 RefSeq WP_000339954 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000339954 STRING 511145.b0132 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0132&targetmode=cogs TIGRFAMs TIGR01784 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01784 UniProtKB YADD_ECOLI http://www.uniprot.org/uniprot/YADD_ECOLI UniProtKB-AC P31665 http://www.uniprot.org/uniprot/P31665 charge swissprot:YADD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YADD_ECOLI eggNOG COG5464 http://eggnogapi.embl.de/nog_data/html/tree/COG5464 eggNOG ENOG4108A32 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108A32 epestfind swissprot:YADD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YADD_ECOLI garnier swissprot:YADD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YADD_ECOLI helixturnhelix swissprot:YADD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YADD_ECOLI hmoment swissprot:YADD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YADD_ECOLI iep swissprot:YADD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YADD_ECOLI inforesidue swissprot:YADD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YADD_ECOLI octanol swissprot:YADD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YADD_ECOLI pepcoil swissprot:YADD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YADD_ECOLI pepdigest swissprot:YADD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YADD_ECOLI pepinfo swissprot:YADD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YADD_ECOLI pepnet swissprot:YADD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YADD_ECOLI pepstats swissprot:YADD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YADD_ECOLI pepwheel swissprot:YADD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YADD_ECOLI pepwindow swissprot:YADD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YADD_ECOLI sigcleave swissprot:YADD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YADD_ECOLI ## Database ID URL or Descriptions # ALTERNATIVE PRODUCTS SRNB_ECOLI Event=Alternative initiation; Named isoforms=2; Name=srnB; IsoId=P13970-1; Sequence=Displayed; Name=srnB'; IsoId=P13970-2; Sequence=VSP_018748; # FUNCTION SRNB_ECOLI Promotes degradation of stable RNA in E.coli. # FUNCTION SRNB_ECOLI When overexpressed, kills the cells from the inside by interfering with a vital function in the cell membrane. Its normal function is believed to be effective plasmid stabilization through postsegregational killing of cells that have lost F. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # InterPro IPR000021 Hok/gef_toxin # InterPro IPR018084 Hok/gef_toxin_CS # Organism SRNB_ECOLI Escherichia coli (strain K12) # PIR C26870 C26870 # PRINTS PR00281 HOKGEFTOXIC # PROSITE PS00556 HOK_GEF # Pfam PF01848 HOK_GEF # ProDom PD005979 Hok/gef_toxin # RecName SRNB_ECOLI Protein SrnB # RefSeq NP_061383 NC_002483.1. [P13970-1] # RefSeq NP_061384 NC_002483.1. [P13970-2] # RefSeq WP_001362723 NZ_CP014273.1 # SIMILARITY Belongs to the hok/gef family. {ECO 0000305}. # SUBCELLULAR LOCATION SRNB_ECOLI Membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. # TCDB 1.E.53.1.11 the toxic hok/gef protein (hok/gef) family BLAST swissprot:SRNB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SRNB_ECOLI EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL M16168 http://www.ebi.ac.uk/ena/data/view/M16168 EMBL M35279 http://www.ebi.ac.uk/ena/data/view/M35279 EMBL X14442 http://www.ebi.ac.uk/ena/data/view/X14442 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GeneID 1263515 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263515 GeneID 1263549 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263549 InterPro IPR000021 http://www.ebi.ac.uk/interpro/entry/IPR000021 InterPro IPR018084 http://www.ebi.ac.uk/interpro/entry/IPR018084 OMA DCSLFLA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DCSLFLA PRINTS PR00281 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00281 PROSITE PS00556 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00556 PSORT swissprot:SRNB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SRNB_ECOLI PSORT-B swissprot:SRNB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SRNB_ECOLI PSORT2 swissprot:SRNB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SRNB_ECOLI Pfam PF01848 http://pfam.xfam.org/family/PF01848 Phobius swissprot:SRNB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SRNB_ECOLI ProteinModelPortal P13970 http://www.proteinmodelportal.org/query/uniprot/P13970 PubMed 3032897 http://www.ncbi.nlm.nih.gov/pubmed/3032897 RefSeq NP_061383 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061383 RefSeq NP_061384 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061384 RefSeq WP_001362723 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001362723 TCDB 1.E.53.1.11 http://www.tcdb.org/search/result.php?tc=1.E.53.1.11 UniProtKB SRNB_ECOLI http://www.uniprot.org/uniprot/SRNB_ECOLI UniProtKB-AC P13970 http://www.uniprot.org/uniprot/P13970 charge swissprot:SRNB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SRNB_ECOLI epestfind swissprot:SRNB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SRNB_ECOLI garnier swissprot:SRNB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SRNB_ECOLI helixturnhelix swissprot:SRNB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SRNB_ECOLI hmoment swissprot:SRNB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SRNB_ECOLI iep swissprot:SRNB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SRNB_ECOLI inforesidue swissprot:SRNB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SRNB_ECOLI octanol swissprot:SRNB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SRNB_ECOLI pepcoil swissprot:SRNB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SRNB_ECOLI pepdigest swissprot:SRNB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SRNB_ECOLI pepinfo swissprot:SRNB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SRNB_ECOLI pepnet swissprot:SRNB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SRNB_ECOLI pepstats swissprot:SRNB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SRNB_ECOLI pepwheel swissprot:SRNB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SRNB_ECOLI pepwindow swissprot:SRNB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SRNB_ECOLI sigcleave swissprot:SRNB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SRNB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260770 182 # EcoGene EG12156 ydaE # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GOslim_function GO:0043167 ion binding # IntAct P38394 5 # InterPro IPR007308 DUF408 # Organism YDAE_ECOLI Escherichia coli (strain K12) # PATRIC 32117982 VBIEscCol129921_1411 # PIR T09177 T09177 # Pfam PF04181 RPAP2_Rtr1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDAE_ECOLI Uncharacterized protein YdaE # RefSeq YP_588451 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA32251.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # eggNOG ENOG4107C82 Bacteria # eggNOG ENOG410Z75V LUCA BLAST swissprot:YDAE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDAE_ECOLI BioCyc ECOL316407:JW1346-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1346-MONOMER BioCyc EcoCyc:MONOMER0-1001 http://biocyc.org/getid?id=EcoCyc:MONOMER0-1001 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M24905 http://www.ebi.ac.uk/ena/data/view/M24905 EMBL M96749 http://www.ebi.ac.uk/ena/data/view/M96749 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL Z23096 http://www.ebi.ac.uk/ena/data/view/Z23096 EchoBASE EB2076 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2076 EcoGene EG12156 http://www.ecogene.org/geneInfo.php?eg_id=EG12156 EnsemblBacteria ABD18659 http://www.ensemblgenomes.org/id/ABD18659 EnsemblBacteria ABD18659 http://www.ensemblgenomes.org/id/ABD18659 EnsemblBacteria BAA14954 http://www.ensemblgenomes.org/id/BAA14954 EnsemblBacteria BAA14954 http://www.ensemblgenomes.org/id/BAA14954 EnsemblBacteria BAA14954 http://www.ensemblgenomes.org/id/BAA14954 EnsemblBacteria b4526 http://www.ensemblgenomes.org/id/b4526 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GeneID 948959 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948959 HOGENOM HOG000009904 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009904&db=HOGENOM6 IntAct P38394 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P38394* InterPro IPR007308 http://www.ebi.ac.uk/interpro/entry/IPR007308 KEGG_Gene ecj:JW1346 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1346 KEGG_Gene eco:b4526 http://www.genome.jp/dbget-bin/www_bget?eco:b4526 PSORT swissprot:YDAE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDAE_ECOLI PSORT-B swissprot:YDAE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDAE_ECOLI PSORT2 swissprot:YDAE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDAE_ECOLI Pfam PF04181 http://pfam.xfam.org/family/PF04181 Phobius swissprot:YDAE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDAE_ECOLI ProteinModelPortal P38394 http://www.proteinmodelportal.org/query/uniprot/P38394 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2649487 http://www.ncbi.nlm.nih.gov/pubmed/2649487 PubMed 7508908 http://www.ncbi.nlm.nih.gov/pubmed/7508908 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq YP_588451 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_588451 STRING 511145.b4526 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4526&targetmode=cogs UniProtKB YDAE_ECOLI http://www.uniprot.org/uniprot/YDAE_ECOLI UniProtKB-AC P38394 http://www.uniprot.org/uniprot/P38394 charge swissprot:YDAE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDAE_ECOLI eggNOG ENOG4107C82 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107C82 eggNOG ENOG410Z75V http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Z75V epestfind swissprot:YDAE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDAE_ECOLI garnier swissprot:YDAE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDAE_ECOLI helixturnhelix swissprot:YDAE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDAE_ECOLI hmoment swissprot:YDAE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDAE_ECOLI iep swissprot:YDAE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDAE_ECOLI inforesidue swissprot:YDAE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDAE_ECOLI octanol swissprot:YDAE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDAE_ECOLI pepcoil swissprot:YDAE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDAE_ECOLI pepdigest swissprot:YDAE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDAE_ECOLI pepinfo swissprot:YDAE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDAE_ECOLI pepnet swissprot:YDAE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDAE_ECOLI pepstats swissprot:YDAE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDAE_ECOLI pepwheel swissprot:YDAE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDAE_ECOLI pepwindow swissprot:YDAE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDAE_ECOLI sigcleave swissprot:YDAE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDAE_ECOLI ## Database ID URL or Descriptions # BioGrid 4261009 8 # CDD cd06261 TM_PBP2 # EcoGene EG12836 yhdY # FUNCTION YHDY_ECOLI Probably part of the binding-protein-dependent transport system YdhWXYZ for an amino acid; probably responsible for the translocation of the substrate across the membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005215 transporter activity; IEA:InterPro. # GO_process GO:0006865 amino acid transport; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006810 transport # Gene3D 1.10.3720.10 -; 1. # IntAct P45768 3 # InterPro IPR000515 MetI-like # InterPro IPR010065 AA_ABC_transptr_permease_3TM # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00232 General L-amino acid transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism YHDY_ECOLI Escherichia coli (strain K12) # PATRIC 32121972 VBIEscCol129921_3370 # PIR H65119 H65119 # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHDY_ECOLI Inner membrane amino-acid ABC transporter permease protein YhdY # RefSeq NP_417736 NC_000913.3 # RefSeq WP_001300681 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA58074.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION YHDY_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF161098 SSF161098 # TCDB 3.A.1.3.26 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR01726 HEQRo_perm_3TM # eggNOG COG0765 LUCA # eggNOG ENOG4105DRP Bacteria BLAST swissprot:YHDY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHDY_ECOLI BioCyc ECOL316407:JW5545-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5545-MONOMER BioCyc EcoCyc:YHDY-MONOMER http://biocyc.org/getid?id=EcoCyc:YHDY-MONOMER COG COG0765 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0765 DIP DIP-12306N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12306N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2685 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2685 EcoGene EG12836 http://www.ecogene.org/geneInfo.php?eg_id=EG12836 EnsemblBacteria AAC76302 http://www.ensemblgenomes.org/id/AAC76302 EnsemblBacteria AAC76302 http://www.ensemblgenomes.org/id/AAC76302 EnsemblBacteria BAE77311 http://www.ensemblgenomes.org/id/BAE77311 EnsemblBacteria BAE77311 http://www.ensemblgenomes.org/id/BAE77311 EnsemblBacteria BAE77311 http://www.ensemblgenomes.org/id/BAE77311 EnsemblBacteria b3270 http://www.ensemblgenomes.org/id/b3270 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_process GO:0006865 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 947764 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947764 HOGENOM HOG000125341 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125341&db=HOGENOM6 InParanoid P45768 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45768 IntAct P45768 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45768* InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 InterPro IPR010065 http://www.ebi.ac.uk/interpro/entry/IPR010065 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5545 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5545 KEGG_Gene eco:b3270 http://www.genome.jp/dbget-bin/www_bget?eco:b3270 KEGG_Orthology KO:K09971 http://www.genome.jp/dbget-bin/www_bget?KO:K09971 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 MINT MINT-1309860 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1309860 OMA LVFWVFC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LVFWVFC PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:YHDY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHDY_ECOLI PSORT-B swissprot:YHDY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHDY_ECOLI PSORT2 swissprot:YHDY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHDY_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Phobius swissprot:YHDY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHDY_ECOLI PhylomeDB P45768 http://phylomedb.org/?seqid=P45768 ProteinModelPortal P45768 http://www.proteinmodelportal.org/query/uniprot/P45768 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417736 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417736 RefSeq WP_001300681 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300681 SMR P45768 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45768 STRING 511145.b3270 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3270&targetmode=cogs STRING COG0765 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0765&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.3.26 http://www.tcdb.org/search/result.php?tc=3.A.1.3.26 TIGRFAMs TIGR01726 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01726 UniProtKB YHDY_ECOLI http://www.uniprot.org/uniprot/YHDY_ECOLI UniProtKB-AC P45768 http://www.uniprot.org/uniprot/P45768 charge swissprot:YHDY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHDY_ECOLI eggNOG COG0765 http://eggnogapi.embl.de/nog_data/html/tree/COG0765 eggNOG ENOG4105DRP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DRP epestfind swissprot:YHDY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHDY_ECOLI garnier swissprot:YHDY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHDY_ECOLI helixturnhelix swissprot:YHDY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHDY_ECOLI hmoment swissprot:YHDY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHDY_ECOLI iep swissprot:YHDY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHDY_ECOLI inforesidue swissprot:YHDY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHDY_ECOLI octanol swissprot:YHDY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHDY_ECOLI pepcoil swissprot:YHDY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHDY_ECOLI pepdigest swissprot:YHDY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHDY_ECOLI pepinfo swissprot:YHDY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHDY_ECOLI pepnet swissprot:YHDY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHDY_ECOLI pepstats swissprot:YHDY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHDY_ECOLI pepwheel swissprot:YHDY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHDY_ECOLI pepwindow swissprot:YHDY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHDY_ECOLI sigcleave swissprot:YHDY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHDY_ECOLI ## Database ID URL or Descriptions # AltName HICA_ECOLI Endoribonuclease HicA # AltName HICA_ECOLI Toxin HicA # BioGrid 4259495 185 # EcoGene EG14421 hicA # FUNCTION HICA_ECOLI Toxic component of a toxin-antitoxin (TA) module. A probable translation-independent mRNA interferase. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation; this blockage is overcome (after 90 minutes) by subsequent expression of antitoxin HicB. Overexpression causes cleavage of a number of mRNAs and tmRNA, in a translation-independent fashion, suggesting this is an mRNA interferase. {ECO 0000269|PubMed 19060138}. # GO_function GO:0003729 mRNA binding; IEA:InterPro. # GO_function GO:0004521 endoribonuclease activity; IMP:EcoCyc. # GO_process GO:0006402 mRNA catabolic process; IMP:EcoCyc. # GOslim_function GO:0003729 mRNA binding # GOslim_function GO:0004518 nuclease activity # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # INDUCTION Induced by amino acid starvation, carbon starvation and when translation is blocked. Induction no longer occurs in the absence of Lon protease suggesting, by homology to other toxin- antitoxin systems, that it may degrade the HicB antitoxin. A member of the hicA-hicB operon. {ECO:0000269|PubMed 19060138}. # IntAct P76106 2 # InterPro IPR012933 HicA_mRNA_interferase # Organism HICA_ECOLI Escherichia coli (strain K12) # PIR H64895 H64895 # Pfam PF07927 HicA_toxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HICA_ECOLI Probable mRNA interferase HicA # RefSeq NP_415954 NC_000913.3 # RefSeq WP_000813794 NZ_LN832404.1 # SIMILARITY Belongs to the HicA mRNA interferase family. {ECO 0000305}. # SUBUNIT Probably forms a complex with the antitoxin HicB which inhibits the mRNA interferase activity. {ECO 0000250}. # eggNOG ENOG41063XI Bacteria # eggNOG ENOG4112C6R LUCA BLAST swissprot:HICA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HICA_ECOLI BioCyc ECOL316407:JW5230-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5230-MONOMER BioCyc EcoCyc:MONOMER0-2673 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2673 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/bioinformatics/btl418 http://dx.doi.org/10.1093/bioinformatics/btl418 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01013-08 http://dx.doi.org/10.1128/JB.01013-08 EC_number EC:3.1.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.-.- http://enzyme.expasy.org/EC/3.1.-.- EcoGene EG14421 http://www.ecogene.org/geneInfo.php?eg_id=EG14421 EnsemblBacteria AAC74519 http://www.ensemblgenomes.org/id/AAC74519 EnsemblBacteria AAC74519 http://www.ensemblgenomes.org/id/AAC74519 EnsemblBacteria BAE76438 http://www.ensemblgenomes.org/id/BAE76438 EnsemblBacteria BAE76438 http://www.ensemblgenomes.org/id/BAE76438 EnsemblBacteria BAE76438 http://www.ensemblgenomes.org/id/BAE76438 EnsemblBacteria b4532 http://www.ensemblgenomes.org/id/b4532 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003729 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003729 GO_function GO:0004521 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004521 GO_process GO:0006402 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006402 GOslim_function GO:0003729 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003729 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 GeneID 945989 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945989 HOGENOM HOG000296902 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000296902&db=HOGENOM6 IntAct P76106 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76106* IntEnz 3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1 InterPro IPR012933 http://www.ebi.ac.uk/interpro/entry/IPR012933 KEGG_Gene ecj:JW5230 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5230 KEGG_Gene eco:b4532 http://www.genome.jp/dbget-bin/www_bget?eco:b4532 OMA KRSVMPR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KRSVMPR PSORT swissprot:HICA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HICA_ECOLI PSORT-B swissprot:HICA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HICA_ECOLI PSORT2 swissprot:HICA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HICA_ECOLI Pfam PF07927 http://pfam.xfam.org/family/PF07927 Phobius swissprot:HICA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HICA_ECOLI ProteinModelPortal P76106 http://www.proteinmodelportal.org/query/uniprot/P76106 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16895922 http://www.ncbi.nlm.nih.gov/pubmed/16895922 PubMed 19060138 http://www.ncbi.nlm.nih.gov/pubmed/19060138 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415954 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415954 RefSeq WP_000813794 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000813794 STRING 511145.b4532 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4532&targetmode=cogs UniProtKB HICA_ECOLI http://www.uniprot.org/uniprot/HICA_ECOLI UniProtKB-AC P76106 http://www.uniprot.org/uniprot/P76106 charge swissprot:HICA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HICA_ECOLI eggNOG ENOG41063XI http://eggnogapi.embl.de/nog_data/html/tree/ENOG41063XI eggNOG ENOG4112C6R http://eggnogapi.embl.de/nog_data/html/tree/ENOG4112C6R epestfind swissprot:HICA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HICA_ECOLI garnier swissprot:HICA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HICA_ECOLI helixturnhelix swissprot:HICA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HICA_ECOLI hmoment swissprot:HICA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HICA_ECOLI iep swissprot:HICA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HICA_ECOLI inforesidue swissprot:HICA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HICA_ECOLI octanol swissprot:HICA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HICA_ECOLI pepcoil swissprot:HICA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HICA_ECOLI pepdigest swissprot:HICA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HICA_ECOLI pepinfo swissprot:HICA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HICA_ECOLI pepnet swissprot:HICA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HICA_ECOLI pepstats swissprot:HICA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HICA_ECOLI pepwheel swissprot:HICA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HICA_ECOLI pepwindow swissprot:HICA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HICA_ECOLI sigcleave swissprot:HICA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HICA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259982 13 # EcoGene EG13473 gsiB # FUNCTION GSIB_ECOLI Part of the ABC transporter complex GsiABCD involved in glutathione import. {ECO 0000269|PubMed 16109926}. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IEA:InterPro. # GO_function GO:0034634 glutathione transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0034775 glutathione transmembrane transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043234 protein complex # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006950 response to stress # GOslim_process GO:0055085 transmembrane transport # InterPro IPR000914 SBP_5_dom # InterPro IPR023765 SBP_5_CS # InterPro IPR030678 Peptide/Ni-bd # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00348 Glutathione transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism GSIB_ECOLI Escherichia coli (strain K12) # PATRIC 32116863 VBIEscCol129921_0857 # PDB 1UQW X-ray; 2.72 A; A/B=24-512 # PIR F64820 F64820 # PIRSF PIRSF002741 MppA # PROSITE PS01040 SBP_BACTERIAL_5 # Pfam PF00496 SBP_bac_5 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GSIB_ECOLI Glutathione-binding protein GsiB # RefSeq NP_415351 NC_000913.3 # RefSeq WP_000090140 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial solute-binding protein 5 family. {ECO 0000305}. # SUBCELLULAR LOCATION GSIB_ECOLI Periplasm {ECO 0000305}. # SUBUNIT The complex is composed of two ATP-binding proteins (GsiA), two transmembrane proteins (GsiC and GsiD) and a solute- binding protein (GsiB). {ECO 0000305}. # TCDB 3.A.1.5.11 the atp-binding cassette (abc) superfamily # eggNOG COG0747 LUCA # eggNOG ENOG4105DEF Bacteria BLAST swissprot:GSIB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GSIB_ECOLI BioCyc ECOL316407:JW5111-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5111-MONOMER BioCyc EcoCyc:YLIB-MONOMER http://biocyc.org/getid?id=EcoCyc:YLIB-MONOMER BioCyc MetaCyc:YLIB-MONOMER http://biocyc.org/getid?id=MetaCyc:YLIB-MONOMER COG COG0747 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0747 DIP DIP-12697N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12697N DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1023/A:1026177202925 http://dx.doi.org/10.1023/A:1026177202925 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.187.17.5861-5867.2005 http://dx.doi.org/10.1128/JB.187.17.5861-5867.2005 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3246 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3246 EcoGene EG13473 http://www.ecogene.org/geneInfo.php?eg_id=EG13473 EnsemblBacteria AAC73917 http://www.ensemblgenomes.org/id/AAC73917 EnsemblBacteria AAC73917 http://www.ensemblgenomes.org/id/AAC73917 EnsemblBacteria BAA35525 http://www.ensemblgenomes.org/id/BAA35525 EnsemblBacteria BAA35525 http://www.ensemblgenomes.org/id/BAA35525 EnsemblBacteria BAA35525 http://www.ensemblgenomes.org/id/BAA35525 EnsemblBacteria b0830 http://www.ensemblgenomes.org/id/b0830 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0034634 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034634 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0034775 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034775 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 945459 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945459 HOGENOM HOG000164955 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000164955&db=HOGENOM6 InParanoid P75797 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75797 InterPro IPR000914 http://www.ebi.ac.uk/interpro/entry/IPR000914 InterPro IPR023765 http://www.ebi.ac.uk/interpro/entry/IPR023765 InterPro IPR030678 http://www.ebi.ac.uk/interpro/entry/IPR030678 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5111 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5111 KEGG_Gene eco:b0830 http://www.genome.jp/dbget-bin/www_bget?eco:b0830 KEGG_Orthology KO:K13889 http://www.genome.jp/dbget-bin/www_bget?KO:K13889 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA KESPWVP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KESPWVP PDB 1UQW http://www.ebi.ac.uk/pdbe-srv/view/entry/1UQW PDBsum 1UQW http://www.ebi.ac.uk/pdbsum/1UQW PROSITE PS01040 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01040 PSORT swissprot:GSIB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GSIB_ECOLI PSORT-B swissprot:GSIB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GSIB_ECOLI PSORT2 swissprot:GSIB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GSIB_ECOLI Pfam PF00496 http://pfam.xfam.org/family/PF00496 Phobius swissprot:GSIB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GSIB_ECOLI PhylomeDB P75797 http://phylomedb.org/?seqid=P75797 ProteinModelPortal P75797 http://www.proteinmodelportal.org/query/uniprot/P75797 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 14649299 http://www.ncbi.nlm.nih.gov/pubmed/14649299 PubMed 16109926 http://www.ncbi.nlm.nih.gov/pubmed/16109926 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415351 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415351 RefSeq WP_000090140 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000090140 SMR P75797 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75797 STRING 511145.b0830 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0830&targetmode=cogs STRING COG0747 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0747&targetmode=cogs SWISS-2DPAGE P75797 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P75797 TCDB 3.A.1.5.11 http://www.tcdb.org/search/result.php?tc=3.A.1.5.11 UniProtKB GSIB_ECOLI http://www.uniprot.org/uniprot/GSIB_ECOLI UniProtKB-AC P75797 http://www.uniprot.org/uniprot/P75797 charge swissprot:GSIB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GSIB_ECOLI eggNOG COG0747 http://eggnogapi.embl.de/nog_data/html/tree/COG0747 eggNOG ENOG4105DEF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DEF epestfind swissprot:GSIB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GSIB_ECOLI garnier swissprot:GSIB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GSIB_ECOLI helixturnhelix swissprot:GSIB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GSIB_ECOLI hmoment swissprot:GSIB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GSIB_ECOLI iep swissprot:GSIB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GSIB_ECOLI inforesidue swissprot:GSIB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GSIB_ECOLI octanol swissprot:GSIB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GSIB_ECOLI pepcoil swissprot:GSIB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GSIB_ECOLI pepdigest swissprot:GSIB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GSIB_ECOLI pepinfo swissprot:GSIB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GSIB_ECOLI pepnet swissprot:GSIB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GSIB_ECOLI pepstats swissprot:GSIB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GSIB_ECOLI pepwheel swissprot:GSIB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GSIB_ECOLI pepwindow swissprot:GSIB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GSIB_ECOLI sigcleave swissprot:GSIB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GSIB_ECOLI ## Database ID URL or Descriptions # AltName RUVC_ECOLI Holliday junction nuclease RuvC # AltName RUVC_ECOLI Holliday junction resolvase RuvC # BioGrid 4263235 95 # CATALYTIC ACTIVITY RUVC_ECOLI Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction). # COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI 18420; Note=Binds 1 Mg(2+) ion per subunit.; # EcoGene EG10925 ruvC # FUNCTION RUVC_ECOLI Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. {ECO 0000269|PubMed 1661673, ECO 0000269|PubMed 1758493}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_component GO:0048476 Holliday junction resolvase complex; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0003676 nucleic acid binding; IEA:InterPro. # GO_function GO:0008821 crossover junction endodeoxyribonuclease activity; IDA:EcoCyc. # GO_process GO:0000725 recombinational repair; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0004518 nuclease activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # Gene3D 3.30.420.10 -; 1. # HAMAP MF_00034 RuvC # IntAct P0A814 3 # InterPro IPR002176 X-over_junc_endoDNase_RuvC # InterPro IPR012337 RNaseH-like_dom # InterPro IPR020563 X-over_junc_endoDNase_Mg_BS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko03440 Homologous recombination # Organism RUVC_ECOLI Escherichia coli (strain K12) # PATRIC 32119049 VBIEscCol129921_1942 # PDB 1HJR X-ray; 2.50 A; A/B/C/D=2-159 # PIR D38113 D38113 # PRINTS PR00696 RSOLVASERUVC # PROSITE PS01321 RUVC # Pfam PF02075 RuvC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RUVC_ECOLI Crossover junction endodeoxyribonuclease RuvC # RefSeq NP_416377 NC_000913.3 # RefSeq WP_001295503 NZ_LN832404.1 # SIMILARITY Belongs to the RuvC family. {ECO 0000305}. # SUBCELLULAR LOCATION RUVC_ECOLI Cytoplasm {ECO 0000269|PubMed 21219465}. Note=In 15% of cell localizes to discrete nucleoid foci (probable DNA damage sites) upon treatment with mitomycin C (MMC) for 2 hours. # SUBUNIT RUVC_ECOLI Homodimer. # SUPFAM SSF53098 SSF53098 # TIGRFAMs TIGR00228 ruvC # eggNOG COG0817 LUCA # eggNOG ENOG4105NHU Bacteria BLAST swissprot:RUVC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RUVC_ECOLI BioCyc ECOL316407:JW1852-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1852-MONOMER BioCyc EcoCyc:EG10925-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10925-MONOMER BioCyc MetaCyc:EG10925-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10925-MONOMER COG COG0817 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0817 DIP DIP-35952N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35952N DOI 10.1016/0092-8674(94)90280-1 http://dx.doi.org/10.1016/0092-8674(94)90280-1 DOI 10.1038/354506a0 http://dx.doi.org/10.1038/354506a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1111/j.1365-2958.2010.07465.x http://dx.doi.org/10.1111/j.1365-2958.2010.07465.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1146/annurev.genet.31.1.213 http://dx.doi.org/10.1146/annurev.genet.31.1.213 EC_number EC:3.1.22.4 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.22.4 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D10165 http://www.ebi.ac.uk/ena/data/view/D10165 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X59551 http://www.ebi.ac.uk/ena/data/view/X59551 ENZYME 3.1.22.4 http://enzyme.expasy.org/EC/3.1.22.4 EchoBASE EB0918 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0918 EcoGene EG10925 http://www.ecogene.org/geneInfo.php?eg_id=EG10925 EnsemblBacteria AAC74933 http://www.ensemblgenomes.org/id/AAC74933 EnsemblBacteria AAC74933 http://www.ensemblgenomes.org/id/AAC74933 EnsemblBacteria BAA15674 http://www.ensemblgenomes.org/id/BAA15674 EnsemblBacteria BAA15674 http://www.ensemblgenomes.org/id/BAA15674 EnsemblBacteria BAA15674 http://www.ensemblgenomes.org/id/BAA15674 EnsemblBacteria b1863 http://www.ensemblgenomes.org/id/b1863 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0048476 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048476 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0003676 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003676 GO_function GO:0008821 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008821 GO_process GO:0000725 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000725 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.30.420.10 http://www.cathdb.info/version/latest/superfamily/3.30.420.10 GeneID 946378 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946378 HAMAP MF_00034 http://hamap.expasy.org/unirule/MF_00034 HOGENOM HOG000012181 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000012181&db=HOGENOM6 InParanoid P0A814 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A814 IntAct P0A814 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A814* IntEnz 3.1.22.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.22.4 InterPro IPR002176 http://www.ebi.ac.uk/interpro/entry/IPR002176 InterPro IPR012337 http://www.ebi.ac.uk/interpro/entry/IPR012337 InterPro IPR020563 http://www.ebi.ac.uk/interpro/entry/IPR020563 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW1852 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1852 KEGG_Gene eco:b1863 http://www.genome.jp/dbget-bin/www_bget?eco:b1863 KEGG_Orthology KO:K01159 http://www.genome.jp/dbget-bin/www_bget?KO:K01159 KEGG_Pathway ko03440 http://www.genome.jp/kegg-bin/show_pathway?ko03440 OMA FFNRNVT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FFNRNVT PDB 1HJR http://www.ebi.ac.uk/pdbe-srv/view/entry/1HJR PDBsum 1HJR http://www.ebi.ac.uk/pdbsum/1HJR PRINTS PR00696 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00696 PROSITE PS01321 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01321 PSORT swissprot:RUVC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RUVC_ECOLI PSORT-B swissprot:RUVC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RUVC_ECOLI PSORT2 swissprot:RUVC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RUVC_ECOLI Pfam PF02075 http://pfam.xfam.org/family/PF02075 Phobius swissprot:RUVC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RUVC_ECOLI PhylomeDB P0A814 http://phylomedb.org/?seqid=P0A814 ProteinModelPortal P0A814 http://www.proteinmodelportal.org/query/uniprot/P0A814 PubMed 1657895 http://www.ncbi.nlm.nih.gov/pubmed/1657895 PubMed 1661673 http://www.ncbi.nlm.nih.gov/pubmed/1661673 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1758493 http://www.ncbi.nlm.nih.gov/pubmed/1758493 PubMed 1885548 http://www.ncbi.nlm.nih.gov/pubmed/1885548 PubMed 21219465 http://www.ncbi.nlm.nih.gov/pubmed/21219465 PubMed 7923356 http://www.ncbi.nlm.nih.gov/pubmed/7923356 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9442895 http://www.ncbi.nlm.nih.gov/pubmed/9442895 RefSeq NP_416377 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416377 RefSeq WP_001295503 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295503 SMR P0A814 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A814 STRING 511145.b1863 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1863&targetmode=cogs STRING COG0817 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0817&targetmode=cogs SUPFAM SSF53098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098 TIGRFAMs TIGR00228 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00228 UniProtKB RUVC_ECOLI http://www.uniprot.org/uniprot/RUVC_ECOLI UniProtKB-AC P0A814 http://www.uniprot.org/uniprot/P0A814 charge swissprot:RUVC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RUVC_ECOLI eggNOG COG0817 http://eggnogapi.embl.de/nog_data/html/tree/COG0817 eggNOG ENOG4105NHU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105NHU epestfind swissprot:RUVC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RUVC_ECOLI garnier swissprot:RUVC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RUVC_ECOLI helixturnhelix swissprot:RUVC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RUVC_ECOLI hmoment swissprot:RUVC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RUVC_ECOLI iep swissprot:RUVC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RUVC_ECOLI inforesidue swissprot:RUVC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RUVC_ECOLI octanol swissprot:RUVC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RUVC_ECOLI pepcoil swissprot:RUVC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RUVC_ECOLI pepdigest swissprot:RUVC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RUVC_ECOLI pepinfo swissprot:RUVC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RUVC_ECOLI pepnet swissprot:RUVC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RUVC_ECOLI pepstats swissprot:RUVC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RUVC_ECOLI pepwheel swissprot:RUVC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RUVC_ECOLI pepwindow swissprot:RUVC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RUVC_ECOLI sigcleave swissprot:RUVC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RUVC_ECOLI ## Database ID URL or Descriptions # BRENDA 1.1.1.37 2026 # BioGrid 4260779 18 # CATALYTIC ACTIVITY MDH_ECOLI (S)-malate + NAD(+) = oxaloacetate + NADH. {ECO 0000255|HAMAP-Rule MF_01516, ECO 0000269|PubMed 2993232, ECO 0000269|PubMed 7028159}. # DrugBank DB00336 Nitrofural # EcoGene EG10576 mdh # FUNCTION MDH_ECOLI Catalyzes the reversible oxidation of malate to oxaloacetate. {ECO 0000255|HAMAP-Rule MF_01516, ECO 0000269|PubMed 2993232, ECO 0000269|PubMed 7028159}. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_component GO:0019898 extrinsic component of membrane; IDA:EcoliWiki. # GO_function GO:0016491 oxidoreductase activity; IDA:EcoliWiki. # GO_function GO:0016615 malate dehydrogenase activity; IDA:EcoliWiki. # GO_function GO:0030060 L-malate dehydrogenase activity; IEA:UniProtKB-HAMAP. # GO_process GO:0006096 glycolytic process; IDA:EcoliWiki. # GO_process GO:0006099 tricarboxylic acid cycle; IDA:EcoliWiki. # GO_process GO:0006108 malate metabolic process; IDA:EcoliWiki. # GO_process GO:0006113 fermentation; IDA:EcoliWiki. # GO_process GO:0009061 anaerobic respiration; IDA:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.720 -; 1. # Gene3D 3.90.110.10 -; 1. # HAMAP MF_01516 Malate_dehydrog_1 # IntAct P61889 10 # InterPro IPR001236 Lactate/malate_DH_N # InterPro IPR001252 Malate_DH_AS # InterPro IPR001557 L-lactate/malate_DH # InterPro IPR010097 Malate_DH_type1 # InterPro IPR015955 Lactate_DH/Glyco_Ohase_4_C # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR022383 Lactate/malate_DH_C # InterPro IPR023958 Malate_DH_type1_bac # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00020 Citrate cycle (TCA cycle) # KEGG_Pathway ko00620 Pyruvate metabolism # KEGG_Pathway ko00630 Glyoxylate and dicarboxylate metabolism # KEGG_Pathway ko00680 Methane metabolism # KEGG_Pathway ko00710 Carbon fixation in photosynthetic organisms # KEGG_Pathway ko00720 Carbon fixation pathways in prokaryotes # Organism MDH_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11540 PTHR11540 # PATRIC 32121898 VBIEscCol129921_3333 # PDB 1CME Model; -; A=1-312 # PDB 1EMD X-ray; 1.90 A; A=1-312 # PDB 1IB6 X-ray; 2.10 A; A/B/C/D=1-312 # PDB 1IE3 X-ray; 2.50 A; A/B/C/D=1-312 # PDB 2CMD X-ray; 1.87 A; A=1-312 # PDB 2PWZ X-ray; 2.20 A; A/C/E/G=1-312 # PDB 3HHP X-ray; 1.45 A; A/B/C/D=1-312 # PIR F65115 DEECM # PIRSF PIRSF000102 Lac_mal_DH # PROSITE PS00068 MDH # Pfam PF00056 Ldh_1_N # Pfam PF02866 Ldh_1_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MDH_ECOLI Malate dehydrogenase {ECO 0000255|HAMAP-Rule MF_01516, ECO 0000303|PubMed 7028159} # RefSeq NP_417703 NC_000913.3 # RefSeq WP_001295272 NZ_LN832404.1 # SIMILARITY Belongs to the LDH/MDH superfamily. MDH type 1 family. {ECO:0000255|HAMAP-Rule MF_01516, ECO:0000305}. # SUBUNIT MDH_ECOLI Homodimer. {ECO 0000255|HAMAP-Rule MF_01516, ECO 0000269|PubMed 11389141, ECO 0000269|PubMed 1507230, ECO 0000269|PubMed 7028159, ECO 0000269|PubMed 8331658}. # SUPFAM SSF51735 SSF51735 # SUPFAM SSF56327 SSF56327 # TIGRFAMs TIGR01772 MDH_euk_gproteo # eggNOG COG0039 LUCA # eggNOG ENOG4105C80 Bacteria BLAST swissprot:MDH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MDH_ECOLI BioCyc ECOL316407:JW3205-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3205-MONOMER BioCyc EcoCyc:MALATE-DEHASE-MONOMER http://biocyc.org/getid?id=EcoCyc:MALATE-DEHASE-MONOMER BioCyc MetaCyc:MALATE-DEHASE-MONOMER http://biocyc.org/getid?id=MetaCyc:MALATE-DEHASE-MONOMER COG COG0039 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0039 DIP DIP-35924N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35924N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1993.1377 http://dx.doi.org/10.1006/jmbi.1993.1377 DOI 10.1006/jmbi.1998.1726 http://dx.doi.org/10.1006/jmbi.1998.1726 DOI 10.1007/BF00423133 http://dx.doi.org/10.1007/BF00423133 DOI 10.1007/BF01121583 http://dx.doi.org/10.1007/BF01121583 DOI 10.1016/0022-2836(92)90637-Y http://dx.doi.org/10.1016/0022-2836(92)90637-Y DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1462-2920.2000.00142.x http://dx.doi.org/10.1046/j.1462-2920.2000.00142.x DOI 10.1073/pnas.90.11.5011 http://dx.doi.org/10.1073/pnas.90.11.5011 DOI 10.1073/pnas.91.4.1280 http://dx.doi.org/10.1073/pnas.91.4.1280 DOI 10.1074/jbc.M100902200 http://dx.doi.org/10.1074/jbc.M100902200 DOI 10.1093/nar/15.12.4993 http://dx.doi.org/10.1093/nar/15.12.4993 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB00336 http://www.drugbank.ca/drugs/DB00336 EC_number EC:1.1.1.37 {ECO:0000255|HAMAP-Rule:MF_01516, ECO:0000269|PubMed:2993232, ECO:0000269|PubMed:7028159} http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.37 {ECO:0000255|HAMAP-Rule:MF_01516, ECO:0000269|PubMed:2993232, ECO:0000269|PubMed:7028159} EMBL AF004170 http://www.ebi.ac.uk/ena/data/view/AF004170 EMBL AF004171 http://www.ebi.ac.uk/ena/data/view/AF004171 EMBL AF004172 http://www.ebi.ac.uk/ena/data/view/AF004172 EMBL AF004173 http://www.ebi.ac.uk/ena/data/view/AF004173 EMBL AF004174 http://www.ebi.ac.uk/ena/data/view/AF004174 EMBL AF004175 http://www.ebi.ac.uk/ena/data/view/AF004175 EMBL AF004176 http://www.ebi.ac.uk/ena/data/view/AF004176 EMBL AF004177 http://www.ebi.ac.uk/ena/data/view/AF004177 EMBL AF004179 http://www.ebi.ac.uk/ena/data/view/AF004179 EMBL AF004180 http://www.ebi.ac.uk/ena/data/view/AF004180 EMBL AF004182 http://www.ebi.ac.uk/ena/data/view/AF004182 EMBL AF004183 http://www.ebi.ac.uk/ena/data/view/AF004183 EMBL AF004184 http://www.ebi.ac.uk/ena/data/view/AF004184 EMBL AF004186 http://www.ebi.ac.uk/ena/data/view/AF004186 EMBL AF004187 http://www.ebi.ac.uk/ena/data/view/AF004187 EMBL AF004188 http://www.ebi.ac.uk/ena/data/view/AF004188 EMBL AF004190 http://www.ebi.ac.uk/ena/data/view/AF004190 EMBL AF004191 http://www.ebi.ac.uk/ena/data/view/AF004191 EMBL AF004195 http://www.ebi.ac.uk/ena/data/view/AF004195 EMBL AF004196 http://www.ebi.ac.uk/ena/data/view/AF004196 EMBL AF004199 http://www.ebi.ac.uk/ena/data/view/AF004199 EMBL AF004200 http://www.ebi.ac.uk/ena/data/view/AF004200 EMBL AF004201 http://www.ebi.ac.uk/ena/data/view/AF004201 EMBL AF004202 http://www.ebi.ac.uk/ena/data/view/AF004202 EMBL AF004203 http://www.ebi.ac.uk/ena/data/view/AF004203 EMBL AF004204 http://www.ebi.ac.uk/ena/data/view/AF004204 EMBL AF004205 http://www.ebi.ac.uk/ena/data/view/AF004205 EMBL AF004206 http://www.ebi.ac.uk/ena/data/view/AF004206 EMBL AF004207 http://www.ebi.ac.uk/ena/data/view/AF004207 EMBL AF004208 http://www.ebi.ac.uk/ena/data/view/AF004208 EMBL AF004209 http://www.ebi.ac.uk/ena/data/view/AF004209 EMBL AF091758 http://www.ebi.ac.uk/ena/data/view/AF091758 EMBL AF091759 http://www.ebi.ac.uk/ena/data/view/AF091759 EMBL AF091760 http://www.ebi.ac.uk/ena/data/view/AF091760 EMBL AF091761 http://www.ebi.ac.uk/ena/data/view/AF091761 EMBL AF091762 http://www.ebi.ac.uk/ena/data/view/AF091762 EMBL AF091763 http://www.ebi.ac.uk/ena/data/view/AF091763 EMBL AF091764 http://www.ebi.ac.uk/ena/data/view/AF091764 EMBL AF091765 http://www.ebi.ac.uk/ena/data/view/AF091765 EMBL AF091766 http://www.ebi.ac.uk/ena/data/view/AF091766 EMBL AF091767 http://www.ebi.ac.uk/ena/data/view/AF091767 EMBL AF091768 http://www.ebi.ac.uk/ena/data/view/AF091768 EMBL AF091769 http://www.ebi.ac.uk/ena/data/view/AF091769 EMBL AF091770 http://www.ebi.ac.uk/ena/data/view/AF091770 EMBL AF091771 http://www.ebi.ac.uk/ena/data/view/AF091771 EMBL AF091772 http://www.ebi.ac.uk/ena/data/view/AF091772 EMBL AF091773 http://www.ebi.ac.uk/ena/data/view/AF091773 EMBL AF091774 http://www.ebi.ac.uk/ena/data/view/AF091774 EMBL AF091775 http://www.ebi.ac.uk/ena/data/view/AF091775 EMBL AF091776 http://www.ebi.ac.uk/ena/data/view/AF091776 EMBL AF091777 http://www.ebi.ac.uk/ena/data/view/AF091777 EMBL AF091778 http://www.ebi.ac.uk/ena/data/view/AF091778 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M10417 http://www.ebi.ac.uk/ena/data/view/M10417 EMBL M24777 http://www.ebi.ac.uk/ena/data/view/M24777 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U04742 http://www.ebi.ac.uk/ena/data/view/U04742 EMBL U04743 http://www.ebi.ac.uk/ena/data/view/U04743 EMBL U04744 http://www.ebi.ac.uk/ena/data/view/U04744 EMBL U04745 http://www.ebi.ac.uk/ena/data/view/U04745 EMBL U04746 http://www.ebi.ac.uk/ena/data/view/U04746 EMBL U04747 http://www.ebi.ac.uk/ena/data/view/U04747 EMBL U04748 http://www.ebi.ac.uk/ena/data/view/U04748 EMBL U04749 http://www.ebi.ac.uk/ena/data/view/U04749 EMBL U04750 http://www.ebi.ac.uk/ena/data/view/U04750 EMBL U04751 http://www.ebi.ac.uk/ena/data/view/U04751 EMBL U04752 http://www.ebi.ac.uk/ena/data/view/U04752 EMBL U04753 http://www.ebi.ac.uk/ena/data/view/U04753 EMBL U04754 http://www.ebi.ac.uk/ena/data/view/U04754 EMBL U04755 http://www.ebi.ac.uk/ena/data/view/U04755 EMBL U04756 http://www.ebi.ac.uk/ena/data/view/U04756 EMBL U04757 http://www.ebi.ac.uk/ena/data/view/U04757 EMBL U04758 http://www.ebi.ac.uk/ena/data/view/U04758 EMBL U04759 http://www.ebi.ac.uk/ena/data/view/U04759 EMBL U04760 http://www.ebi.ac.uk/ena/data/view/U04760 EMBL U04770 http://www.ebi.ac.uk/ena/data/view/U04770 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL Y00129 http://www.ebi.ac.uk/ena/data/view/Y00129 ENZYME 1.1.1.37 {ECO:0000255|HAMAP-Rule:MF_01516, ECO:0000269|PubMed:2993232, ECO:0000269|PubMed:7028159} http://enzyme.expasy.org/EC/1.1.1.37 {ECO:0000255|HAMAP-Rule:MF_01516, ECO:0000269|PubMed:2993232, ECO:0000269|PubMed:7028159} EchoBASE EB0571 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0571 EcoGene EG10576 http://www.ecogene.org/geneInfo.php?eg_id=EG10576 EnsemblBacteria AAC76268 http://www.ensemblgenomes.org/id/AAC76268 EnsemblBacteria AAC76268 http://www.ensemblgenomes.org/id/AAC76268 EnsemblBacteria BAE77279 http://www.ensemblgenomes.org/id/BAE77279 EnsemblBacteria BAE77279 http://www.ensemblgenomes.org/id/BAE77279 EnsemblBacteria BAE77279 http://www.ensemblgenomes.org/id/BAE77279 EnsemblBacteria b3236 http://www.ensemblgenomes.org/id/b3236 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0019898 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019898 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0016615 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016615 GO_function GO:0030060 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030060 GO_process GO:0006096 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006096 GO_process GO:0006099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006099 GO_process GO:0006108 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006108 GO_process GO:0006113 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006113 GO_process GO:0009061 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009061 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 Gene3D 3.90.110.10 http://www.cathdb.info/version/latest/superfamily/3.90.110.10 GeneID 947854 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947854 HAMAP MF_01516 http://hamap.expasy.org/unirule/MF_01516 InParanoid P61889 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P61889 IntAct P61889 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P61889* IntEnz 1.1.1.37 {ECO:0000255|HAMAP-Rule:MF_01516, ECO:0000269|PubMed:2993232, ECO:0000269|PubMed:7028159} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.37 {ECO:0000255|HAMAP-Rule:MF_01516, ECO:0000269|PubMed:2993232, ECO:0000269|PubMed:7028159} InterPro IPR001236 http://www.ebi.ac.uk/interpro/entry/IPR001236 InterPro IPR001252 http://www.ebi.ac.uk/interpro/entry/IPR001252 InterPro IPR001557 http://www.ebi.ac.uk/interpro/entry/IPR001557 InterPro IPR010097 http://www.ebi.ac.uk/interpro/entry/IPR010097 InterPro IPR015955 http://www.ebi.ac.uk/interpro/entry/IPR015955 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR022383 http://www.ebi.ac.uk/interpro/entry/IPR022383 InterPro IPR023958 http://www.ebi.ac.uk/interpro/entry/IPR023958 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3205 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3205 KEGG_Gene eco:b3236 http://www.genome.jp/dbget-bin/www_bget?eco:b3236 KEGG_Orthology KO:K00024 http://www.genome.jp/dbget-bin/www_bget?KO:K00024 KEGG_Pathway ko00020 http://www.genome.jp/kegg-bin/show_pathway?ko00020 KEGG_Pathway ko00620 http://www.genome.jp/kegg-bin/show_pathway?ko00620 KEGG_Pathway ko00630 http://www.genome.jp/kegg-bin/show_pathway?ko00630 KEGG_Pathway ko00680 http://www.genome.jp/kegg-bin/show_pathway?ko00680 KEGG_Pathway ko00710 http://www.genome.jp/kegg-bin/show_pathway?ko00710 KEGG_Pathway ko00720 http://www.genome.jp/kegg-bin/show_pathway?ko00720 KEGG_Reaction rn:R00342 http://www.genome.jp/dbget-bin/www_bget?rn:R00342 OMA VEVKGFA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VEVKGFA PANTHER PTHR11540 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11540 PDB 1CME http://www.ebi.ac.uk/pdbe-srv/view/entry/1CME PDB 1EMD http://www.ebi.ac.uk/pdbe-srv/view/entry/1EMD PDB 1IB6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1IB6 PDB 1IE3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1IE3 PDB 2CMD http://www.ebi.ac.uk/pdbe-srv/view/entry/2CMD PDB 2PWZ http://www.ebi.ac.uk/pdbe-srv/view/entry/2PWZ PDB 3HHP http://www.ebi.ac.uk/pdbe-srv/view/entry/3HHP PDBsum 1CME http://www.ebi.ac.uk/pdbsum/1CME PDBsum 1EMD http://www.ebi.ac.uk/pdbsum/1EMD PDBsum 1IB6 http://www.ebi.ac.uk/pdbsum/1IB6 PDBsum 1IE3 http://www.ebi.ac.uk/pdbsum/1IE3 PDBsum 2CMD http://www.ebi.ac.uk/pdbsum/2CMD PDBsum 2PWZ http://www.ebi.ac.uk/pdbsum/2PWZ PDBsum 3HHP http://www.ebi.ac.uk/pdbsum/3HHP PROSITE PS00068 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00068 PSORT swissprot:MDH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MDH_ECOLI PSORT-B swissprot:MDH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MDH_ECOLI PSORT2 swissprot:MDH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MDH_ECOLI Pfam PF00056 http://pfam.xfam.org/family/PF00056 Pfam PF02866 http://pfam.xfam.org/family/PF02866 Phobius swissprot:MDH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MDH_ECOLI PhylomeDB P61889 http://phylomedb.org/?seqid=P61889 ProteinModelPortal P61889 http://www.proteinmodelportal.org/query/uniprot/P61889 PubMed 11214793 http://www.ncbi.nlm.nih.gov/pubmed/11214793 PubMed 11389141 http://www.ncbi.nlm.nih.gov/pubmed/11389141 PubMed 1507230 http://www.ncbi.nlm.nih.gov/pubmed/1507230 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2993232 http://www.ncbi.nlm.nih.gov/pubmed/2993232 PubMed 3299262 http://www.ncbi.nlm.nih.gov/pubmed/3299262 PubMed 3322223 http://www.ncbi.nlm.nih.gov/pubmed/3322223 PubMed 7028159 http://www.ncbi.nlm.nih.gov/pubmed/7028159 PubMed 8108402 http://www.ncbi.nlm.nih.gov/pubmed/8108402 PubMed 8331658 http://www.ncbi.nlm.nih.gov/pubmed/8331658 PubMed 8506346 http://www.ncbi.nlm.nih.gov/pubmed/8506346 PubMed 8670822 http://www.ncbi.nlm.nih.gov/pubmed/8670822 PubMed 9190829 http://www.ncbi.nlm.nih.gov/pubmed/9190829 PubMed 9199437 http://www.ncbi.nlm.nih.gov/pubmed/9199437 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 RefSeq NP_417703 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417703 RefSeq WP_001295272 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295272 SMR P61889 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P61889 STRING 511145.b3236 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3236&targetmode=cogs STRING COG0039 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0039&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 SUPFAM SSF56327 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56327 SWISS-2DPAGE P61889 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P61889 TIGRFAMs TIGR01772 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01772 UniProtKB MDH_ECOLI http://www.uniprot.org/uniprot/MDH_ECOLI UniProtKB-AC P61889 http://www.uniprot.org/uniprot/P61889 charge swissprot:MDH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MDH_ECOLI eggNOG COG0039 http://eggnogapi.embl.de/nog_data/html/tree/COG0039 eggNOG ENOG4105C80 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C80 epestfind swissprot:MDH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MDH_ECOLI garnier swissprot:MDH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MDH_ECOLI helixturnhelix swissprot:MDH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MDH_ECOLI hmoment swissprot:MDH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MDH_ECOLI iep swissprot:MDH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MDH_ECOLI inforesidue swissprot:MDH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MDH_ECOLI octanol swissprot:MDH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MDH_ECOLI pepcoil swissprot:MDH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MDH_ECOLI pepdigest swissprot:MDH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MDH_ECOLI pepinfo swissprot:MDH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MDH_ECOLI pepnet swissprot:MDH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MDH_ECOLI pepstats swissprot:MDH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MDH_ECOLI pepwheel swissprot:MDH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MDH_ECOLI pepwindow swissprot:MDH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MDH_ECOLI sigcleave swissprot:MDH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MDH_ECOLI ## Database ID URL or Descriptions # BioGrid 4262492 13 # CDD cd06261 TM_PBP2 # EcoGene EG12076 nikB # FUNCTION NIKB_ECOLI Involved in a nickel transport system, probably translocates nickel through the bacterial inner membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0015099 nickel cation transmembrane transporter activity; IMP:EcoCyc. # GO_function GO:0016151 nickel cation binding; IDA:EcoCyc. # GO_process GO:0035444 nickel cation transmembrane transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0055085 transmembrane transport # Gene3D 1.10.3720.10 -; 1. # InterPro IPR000515 MetI-like # InterPro IPR014156 Nickel_NikB # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00440 Nickel transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism NIKB_ECOLI Escherichia coli (strain K12) # PATRIC 32122398 VBIEscCol129921_3576 # PIR S47696 S47696 # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NIKB_ECOLI Nickel transport system permease protein NikB # RefSeq NP_417934 NC_000913.3 # RefSeq WP_000947068 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION NIKB_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT NIKB_ECOLI Probably forms a heterodimeric pore with NikC. # SUPFAM SSF161098 SSF161098 # TCDB 3.A.1.5 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR02789 nickel_nikB # eggNOG COG0601 LUCA # eggNOG ENOG4105CJM Bacteria BLAST swissprot:NIKB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NIKB_ECOLI BioCyc ECOL316407:JW3442-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3442-MONOMER BioCyc EcoCyc:NIKB-MONOMER http://biocyc.org/getid?id=EcoCyc:NIKB-MONOMER BioCyc MetaCyc:NIKB-MONOMER http://biocyc.org/getid?id=MetaCyc:NIKB-MONOMER COG COG0601 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0601 DIP DIP-10341N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10341N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1111/j.1365-2958.1993.tb01247.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb01247.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X73143 http://www.ebi.ac.uk/ena/data/view/X73143 EchoBASE EB2001 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2001 EcoGene EG12076 http://www.ecogene.org/geneInfo.php?eg_id=EG12076 EnsemblBacteria AAC76502 http://www.ensemblgenomes.org/id/AAC76502 EnsemblBacteria AAC76502 http://www.ensemblgenomes.org/id/AAC76502 EnsemblBacteria BAE77816 http://www.ensemblgenomes.org/id/BAE77816 EnsemblBacteria BAE77816 http://www.ensemblgenomes.org/id/BAE77816 EnsemblBacteria BAE77816 http://www.ensemblgenomes.org/id/BAE77816 EnsemblBacteria b3477 http://www.ensemblgenomes.org/id/b3477 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015099 GO_function GO:0016151 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016151 GO_process GO:0035444 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035444 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 947986 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947986 HOGENOM HOG000170251 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000170251&db=HOGENOM6 InParanoid P33591 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33591 InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 InterPro IPR014156 http://www.ebi.ac.uk/interpro/entry/IPR014156 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3442 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3442 KEGG_Gene eco:b3477 http://www.genome.jp/dbget-bin/www_bget?eco:b3477 KEGG_Orthology KO:K15585 http://www.genome.jp/dbget-bin/www_bget?KO:K15585 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA RHEGAHS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RHEGAHS PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:NIKB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NIKB_ECOLI PSORT-B swissprot:NIKB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NIKB_ECOLI PSORT2 swissprot:NIKB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NIKB_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Phobius swissprot:NIKB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NIKB_ECOLI PhylomeDB P33591 http://phylomedb.org/?seqid=P33591 ProteinModelPortal P33591 http://www.proteinmodelportal.org/query/uniprot/P33591 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7934931 http://www.ncbi.nlm.nih.gov/pubmed/7934931 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417934 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417934 RefSeq WP_000947068 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000947068 STRING 511145.b3477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3477&targetmode=cogs STRING COG0601 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0601&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.5 http://www.tcdb.org/search/result.php?tc=3.A.1.5 TIGRFAMs TIGR02789 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02789 UniProtKB NIKB_ECOLI http://www.uniprot.org/uniprot/NIKB_ECOLI UniProtKB-AC P33591 http://www.uniprot.org/uniprot/P33591 charge swissprot:NIKB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NIKB_ECOLI eggNOG COG0601 http://eggnogapi.embl.de/nog_data/html/tree/COG0601 eggNOG ENOG4105CJM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CJM epestfind swissprot:NIKB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NIKB_ECOLI garnier swissprot:NIKB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NIKB_ECOLI helixturnhelix swissprot:NIKB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NIKB_ECOLI hmoment swissprot:NIKB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NIKB_ECOLI iep swissprot:NIKB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NIKB_ECOLI inforesidue swissprot:NIKB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NIKB_ECOLI octanol swissprot:NIKB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NIKB_ECOLI pepcoil swissprot:NIKB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NIKB_ECOLI pepdigest swissprot:NIKB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NIKB_ECOLI pepinfo swissprot:NIKB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NIKB_ECOLI pepnet swissprot:NIKB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NIKB_ECOLI pepstats swissprot:NIKB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NIKB_ECOLI pepwheel swissprot:NIKB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NIKB_ECOLI pepwindow swissprot:NIKB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NIKB_ECOLI sigcleave swissprot:NIKB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NIKB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260567 4 # CDD cd07121 ALDH_EutE # EcoGene EG14185 eutE # FUNCTION EUTE_ECOLI May act as an acetaldehyde dehydrogenase that converts acetaldehyde into acetyl-CoA. # GO_function GO:0004029 aldehyde dehydrogenase (NAD) activity; IMP:CACAO. # GO_process GO:0046336 ethanolamine catabolic process; IEA:UniProtKB-UniPathway. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.309.10 -; 1. # Gene3D 3.40.605.10 -; 1. # IntAct P77445 4 # InterPro IPR012408 Acetald_propionald_DH-rel # InterPro IPR015590 Aldehyde_DH_dom # InterPro IPR016161 Ald_DH/histidinol_DH # InterPro IPR016162 Ald_DH_N # InterPro IPR016163 Ald_DH_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko00362 Benzoate degradation # KEGG_Pathway ko00620 Pyruvate metabolism # KEGG_Pathway ko00621 Dioxin degradation # KEGG_Pathway ko00622 Xylene degradation # Organism EUTE_ECOLI Escherichia coli (strain K12) # PATHWAY EUTE_ECOLI Amine and polyamine degradation; ethanolamine degradation. # PATRIC 32120293 VBIEscCol129921_2549 # PIR F65020 F65020 # PIRSF PIRSF036410 EutE_PduP # Pfam PF00171 Aldedh # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EUTE_ECOLI Ethanolamine utilization protein EutE # RefSeq NP_416950 NC_000913.3 # RefSeq WP_001075716 NZ_LN832404.1 # SUPFAM SSF53720 SSF53720 # eggNOG COG1012 LUCA # eggNOG ENOG4108EKI Bacteria BLAST swissprot:EUTE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EUTE_ECOLI BioCyc ECOL316407:JW2439-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2439-MONOMER BioCyc EcoCyc:G7285-MONOMER http://biocyc.org/getid?id=EcoCyc:G7285-MONOMER COG COG1012 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1012 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3937 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3937 EcoGene EG14185 http://www.ecogene.org/geneInfo.php?eg_id=EG14185 EnsemblBacteria AAC75508 http://www.ensemblgenomes.org/id/AAC75508 EnsemblBacteria AAC75508 http://www.ensemblgenomes.org/id/AAC75508 EnsemblBacteria BAA16333 http://www.ensemblgenomes.org/id/BAA16333 EnsemblBacteria BAA16333 http://www.ensemblgenomes.org/id/BAA16333 EnsemblBacteria BAA16333 http://www.ensemblgenomes.org/id/BAA16333 EnsemblBacteria b2455 http://www.ensemblgenomes.org/id/b2455 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004029 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004029 GO_process GO:0046336 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046336 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.309.10 http://www.cathdb.info/version/latest/superfamily/3.40.309.10 Gene3D 3.40.605.10 http://www.cathdb.info/version/latest/superfamily/3.40.605.10 GeneID 946943 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946943 HOGENOM HOG000288173 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000288173&db=HOGENOM6 InParanoid P77445 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77445 IntAct P77445 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77445* InterPro IPR012408 http://www.ebi.ac.uk/interpro/entry/IPR012408 InterPro IPR015590 http://www.ebi.ac.uk/interpro/entry/IPR015590 InterPro IPR016161 http://www.ebi.ac.uk/interpro/entry/IPR016161 InterPro IPR016162 http://www.ebi.ac.uk/interpro/entry/IPR016162 InterPro IPR016163 http://www.ebi.ac.uk/interpro/entry/IPR016163 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW2439 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2439 KEGG_Gene eco:b2455 http://www.genome.jp/dbget-bin/www_bget?eco:b2455 KEGG_Orthology KO:K04021 http://www.genome.jp/dbget-bin/www_bget?KO:K04021 KEGG_Pathway ko00362 http://www.genome.jp/kegg-bin/show_pathway?ko00362 KEGG_Pathway ko00620 http://www.genome.jp/kegg-bin/show_pathway?ko00620 KEGG_Pathway ko00621 http://www.genome.jp/kegg-bin/show_pathway?ko00621 KEGG_Pathway ko00622 http://www.genome.jp/kegg-bin/show_pathway?ko00622 KEGG_Reaction rn:R00228 http://www.genome.jp/dbget-bin/www_bget?rn:R00228 OMA MGAGHSV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MGAGHSV PSORT swissprot:EUTE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EUTE_ECOLI PSORT-B swissprot:EUTE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EUTE_ECOLI PSORT2 swissprot:EUTE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EUTE_ECOLI Pfam PF00171 http://pfam.xfam.org/family/PF00171 Phobius swissprot:EUTE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EUTE_ECOLI PhylomeDB P77445 http://phylomedb.org/?seqid=P77445 ProteinModelPortal P77445 http://www.proteinmodelportal.org/query/uniprot/P77445 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416950 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416950 RefSeq WP_001075716 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001075716 SMR P77445 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77445 STRING 511145.b2455 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2455&targetmode=cogs STRING COG1012 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1012&targetmode=cogs SUPFAM SSF53720 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53720 UniProtKB EUTE_ECOLI http://www.uniprot.org/uniprot/EUTE_ECOLI UniProtKB-AC P77445 http://www.uniprot.org/uniprot/P77445 charge swissprot:EUTE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EUTE_ECOLI eggNOG COG1012 http://eggnogapi.embl.de/nog_data/html/tree/COG1012 eggNOG ENOG4108EKI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108EKI epestfind swissprot:EUTE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EUTE_ECOLI garnier swissprot:EUTE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EUTE_ECOLI helixturnhelix swissprot:EUTE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EUTE_ECOLI hmoment swissprot:EUTE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EUTE_ECOLI iep swissprot:EUTE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EUTE_ECOLI inforesidue swissprot:EUTE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EUTE_ECOLI octanol swissprot:EUTE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EUTE_ECOLI pepcoil swissprot:EUTE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EUTE_ECOLI pepdigest swissprot:EUTE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EUTE_ECOLI pepinfo swissprot:EUTE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EUTE_ECOLI pepnet swissprot:EUTE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EUTE_ECOLI pepstats swissprot:EUTE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EUTE_ECOLI pepwheel swissprot:EUTE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EUTE_ECOLI pepwindow swissprot:EUTE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EUTE_ECOLI sigcleave swissprot:EUTE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EUTE_ECOLI ## Database ID URL or Descriptions # AltName Competence activator Sxy {ECO:0000303|PubMed 25491382} # BioGrid 4263154 7 # DISRUPTION PHENOTYPE Reduces both natural plasmid transformation and competitive fitness in long-term culture. {ECO:0000269|PubMed 19502395}. # EcoGene EG13720 sxy # FUNCTION SXY_ECOLI Induces low levels of natural DNA uptake by inducing transcription of the competence genes (the CRP-S regulon) required for DNA transformation. Induction of the CRP-S regulon also requires Sxy-activated promoter (CRP-S), cAMP receptor protein (CRP) and cAMP (PubMed 17068078, PubMed 22532864). Induces CRP-S site-containing genes which are involved in genome maintenance and transcription or encoding transposases and toxin-antitoxin pairs (PubMed 19502395). {ECO 0000269|PubMed 17068078, ECO 0000269|PubMed 19502395, ECO 0000269|PubMed 22532864}. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0009290 DNA import into cell involved in transformation; IDA:UniProtKB. # GO_process GO:0030420 establishment of competence for transformation; IEA:UniProtKB-KW. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IMP:EcoCyc. # GO_process GO:0051090 regulation of sequence-specific DNA binding transcription factor activity; IEP:UniProtKB. # GO_process GO:1903658 positive regulation of type IV pilus biogenesis; IDA:UniProtKB. # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.30.1460.30 -; 1. # INDUCTION Not expressed by conditions that usually induce expression in other bacteria, such as amino acid starvation, antibiotics or addition of chitin. Induces its own transcription by a mechanism that requires CRP, cAMP and CRP-S site in its promoter. Negatively regulated at the post-translational level via degradation by Lon protease. {ECO:0000269|PubMed 25491382}. # INTERACTION SXY_ECOLI P75960 cobB; NbExp=8; IntAct=EBI-544452, EBI-544459; P42184 prsA (xeno); NbExp=2; IntAct=EBI-544452, EBI-544466; # IntAct P75869 11 # InterPro IPR007076 TfoX_N # InterPro IPR007077 TfoX_C # InterPro IPR026256 TfoX_Sxy # MISCELLANEOUS SXY_ECOLI Overproduction induces the expression of the competence regulon genes including ppdA, hofB and ssb, although to highly varying degrees (PubMed 25491382). Plasmid-borne expression leads to production of type IV pilin (T4P), the main subunit of the DNA uptake machinery (PubMed 19502395). {ECO 0000269|PubMed 19502395, ECO 0000269|PubMed 25491382}. # Organism SXY_ECOLI Escherichia coli (strain K12) # PATRIC 32117137 VBIEscCol129921_0993 # PIR F64836 F64836 # PIRSF PIRSF028788 TfoX_Sxy # Pfam PF04993 TfoX_N # Pfam PF04994 TfoX_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SXY_ECOLI Protein Sxy # RefSeq NP_415479 NC_000913.3 # RefSeq WP_000839153 NZ_LN832404.1 # SIMILARITY Belongs to the TfoX family. {ECO 0000305}. # eggNOG COG3070 LUCA # eggNOG ENOG4108RZ1 Bacteria BLAST swissprot:SXY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SXY_ECOLI BioCyc ECOL316407:JW0942-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0942-MONOMER BioCyc EcoCyc:G6494-MONOMER http://biocyc.org/getid?id=EcoCyc:G6494-MONOMER COG COG3070 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3070 DIP DIP-11497N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11497N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/gkl734 http://dx.doi.org/10.1093/nar/gkl734 DOI 10.1111/mmi.12901 http://dx.doi.org/10.1111/mmi.12901 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00476-09 http://dx.doi.org/10.1128/JB.00476-09 DOI 10.1371/journal.pone.0035620 http://dx.doi.org/10.1371/journal.pone.0035620 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3484 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3484 EcoGene EG13720 http://www.ecogene.org/geneInfo.php?eg_id=EG13720 EnsemblBacteria AAC74045 http://www.ensemblgenomes.org/id/AAC74045 EnsemblBacteria AAC74045 http://www.ensemblgenomes.org/id/AAC74045 EnsemblBacteria BAA35717 http://www.ensemblgenomes.org/id/BAA35717 EnsemblBacteria BAA35717 http://www.ensemblgenomes.org/id/BAA35717 EnsemblBacteria BAA35717 http://www.ensemblgenomes.org/id/BAA35717 EnsemblBacteria b0959 http://www.ensemblgenomes.org/id/b0959 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0009290 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009290 GO_process GO:0030420 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030420 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GO_process GO:0051090 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051090 GO_process GO:1903658 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903658 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.30.1460.30 http://www.cathdb.info/version/latest/superfamily/3.30.1460.30 GeneID 946504 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946504 HOGENOM HOG000118805 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118805&db=HOGENOM6 IntAct P75869 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75869* InterPro IPR007076 http://www.ebi.ac.uk/interpro/entry/IPR007076 InterPro IPR007077 http://www.ebi.ac.uk/interpro/entry/IPR007077 InterPro IPR026256 http://www.ebi.ac.uk/interpro/entry/IPR026256 KEGG_Gene ecj:JW0942 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0942 KEGG_Gene eco:b0959 http://www.genome.jp/dbget-bin/www_bget?eco:b0959 KEGG_Orthology KO:K07343 http://www.genome.jp/dbget-bin/www_bget?KO:K07343 OMA NELLEWY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NELLEWY PSORT swissprot:SXY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SXY_ECOLI PSORT-B swissprot:SXY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SXY_ECOLI PSORT2 swissprot:SXY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SXY_ECOLI Pfam PF04993 http://pfam.xfam.org/family/PF04993 Pfam PF04994 http://pfam.xfam.org/family/PF04994 Phobius swissprot:SXY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SXY_ECOLI ProteinModelPortal P75869 http://www.proteinmodelportal.org/query/uniprot/P75869 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17068078 http://www.ncbi.nlm.nih.gov/pubmed/17068078 PubMed 19502395 http://www.ncbi.nlm.nih.gov/pubmed/19502395 PubMed 22532864 http://www.ncbi.nlm.nih.gov/pubmed/22532864 PubMed 25491382 http://www.ncbi.nlm.nih.gov/pubmed/25491382 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415479 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415479 RefSeq WP_000839153 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000839153 SMR P75869 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75869 STRING 511145.b0959 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0959&targetmode=cogs STRING COG3070 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3070&targetmode=cogs UniProtKB SXY_ECOLI http://www.uniprot.org/uniprot/SXY_ECOLI UniProtKB-AC P75869 http://www.uniprot.org/uniprot/P75869 charge swissprot:SXY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SXY_ECOLI eggNOG COG3070 http://eggnogapi.embl.de/nog_data/html/tree/COG3070 eggNOG ENOG4108RZ1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108RZ1 epestfind swissprot:SXY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SXY_ECOLI garnier swissprot:SXY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SXY_ECOLI helixturnhelix swissprot:SXY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SXY_ECOLI hmoment swissprot:SXY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SXY_ECOLI iep swissprot:SXY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SXY_ECOLI inforesidue swissprot:SXY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SXY_ECOLI octanol swissprot:SXY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SXY_ECOLI pepcoil swissprot:SXY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SXY_ECOLI pepdigest swissprot:SXY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SXY_ECOLI pepinfo swissprot:SXY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SXY_ECOLI pepnet swissprot:SXY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SXY_ECOLI pepstats swissprot:SXY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SXY_ECOLI pepwheel swissprot:SXY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SXY_ECOLI pepwindow swissprot:SXY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SXY_ECOLI sigcleave swissprot:SXY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SXY_ECOLI ## Database ID URL or Descriptions # BioGrid 4262961 603 # DISRUPTION PHENOTYPE Deletion mutant shows no obvious phenotype, but absence of the protein aggravates the division defect in ftsN or dedD mutants. {ECO:0000269|PubMed 19684127}. # DOMAIN DAMX_ECOLI The SPOR domain binds septal peptidoglycans and is required to target DamX to the septal ring. {ECO 0000255|HAMAP- Rule MF_02021, ECO 0000269|PubMed 19880599, ECO 0000269|PubMed 23290046}. # EcoGene EG11183 damX # FUNCTION DAMX_ECOLI Non-essential cell division protein. {ECO 0000255|HAMAP- Rule MF_02021, ECO 0000269|PubMed 19684127, ECO 0000269|PubMed 19880599}. # GO_component GO:0005887 integral component of plasma membrane; IEA:UniProtKB-HAMAP. # GO_component GO:0030428 cell septum; IDA:EcoCyc. # GO_component GO:0032153 cell division site; IDA:EcoCyc. # GO_function GO:0042834 peptidoglycan binding; IDA:EcoCyc. # GO_process GO:0032506 cytokinetic process; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0008150 biological_process # Gene3D 3.30.70.1070 -; 1. # HAMAP MF_02021 DamX # IntAct P11557 22 # InterPro IPR007730 SPOR_dom # InterPro IPR032899 DamX # MISCELLANEOUS Overexpression induces cell filamentation. {ECO:0000269|PubMed 7603433}. # Organism DAMX_ECOLI Escherichia coli (strain K12) # PATRIC 32122208 VBIEscCol129921_3481 # PDB 2LFV NMR; -; A=338-428 # PIR G65133 Q4ECAD # PROSITE PS51724 SPOR # Pfam PF05036 SPOR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Cell division protein DamX {ECO:0000255|HAMAP-Rule MF_02021, ECO:0000305} # RefSeq NP_417847 NC_000913.3 # RefSeq WP_000343215 NZ_LN832404.1 # SIMILARITY Belongs to the DamX family. {ECO:0000255|HAMAP- Rule MF_02021, ECO:0000305}. # SIMILARITY Contains 1 SPOR domain. {ECO:0000255|HAMAP- Rule MF_02021}. # SUBCELLULAR LOCATION DAMX_ECOLI Cell inner membrane {ECO 0000305}; Single- pass membrane protein {ECO 0000255|HAMAP-Rule MF_02021}. Note=Localizes at the septal ring (PubMed 19684127, PubMed 19880599, PubMed 23290046). Recruitment to the septal ring requires FtsZ (PubMed 19880599). {ECO 0000269|PubMed 19684127, ECO 0000269|PubMed 19880599, ECO 0000269|PubMed 23290046}. # SUBUNIT Interacts in vitro with multiple Fts proteins, including FtsQ and FtsN. {ECO:0000269|PubMed 19880599}. # SUPFAM SSF110997 SSF110997 # eggNOG COG3266 LUCA # eggNOG ENOG4105EGB Bacteria BLAST swissprot:DAMX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DAMX_ECOLI BioCyc ECOL316407:JW3351-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3351-MONOMER BioCyc EcoCyc:EG11183-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11183-MONOMER COG COG3266 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3266 DIP DIP-9397N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9397N DOI 10.1007/BF00290345 http://dx.doi.org/10.1007/BF00290345 DOI 10.1007/BF00330946 http://dx.doi.org/10.1007/BF00330946 DOI 10.1021/bi301609e http://dx.doi.org/10.1021/bi301609e DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00811-09 http://dx.doi.org/10.1128/JB.00811-09 DOI 10.1128/JB.01244-09 http://dx.doi.org/10.1128/JB.01244-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X15162 http://www.ebi.ac.uk/ena/data/view/X15162 EMBL Z19601 http://www.ebi.ac.uk/ena/data/view/Z19601 EchoBASE EB1170 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1170 EcoGene EG11183 http://www.ecogene.org/geneInfo.php?eg_id=EG11183 EnsemblBacteria AAC76413 http://www.ensemblgenomes.org/id/AAC76413 EnsemblBacteria AAC76413 http://www.ensemblgenomes.org/id/AAC76413 EnsemblBacteria BAE77903 http://www.ensemblgenomes.org/id/BAE77903 EnsemblBacteria BAE77903 http://www.ensemblgenomes.org/id/BAE77903 EnsemblBacteria BAE77903 http://www.ensemblgenomes.org/id/BAE77903 EnsemblBacteria b3388 http://www.ensemblgenomes.org/id/b3388 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0030428 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030428 GO_component GO:0032153 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032153 GO_function GO:0042834 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042834 GO_process GO:0032506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032506 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.30.70.1070 http://www.cathdb.info/version/latest/superfamily/3.30.70.1070 GeneID 947930 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947930 HAMAP MF_02021 http://hamap.expasy.org/unirule/MF_02021 HOGENOM HOG000125518 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125518&db=HOGENOM6 InParanoid P11557 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P11557 IntAct P11557 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P11557* InterPro IPR007730 http://www.ebi.ac.uk/interpro/entry/IPR007730 InterPro IPR032899 http://www.ebi.ac.uk/interpro/entry/IPR032899 KEGG_Gene ecj:JW3351 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3351 KEGG_Gene eco:b3388 http://www.genome.jp/dbget-bin/www_bget?eco:b3388 KEGG_Orthology KO:K03112 http://www.genome.jp/dbget-bin/www_bget?KO:K03112 OMA ASRQYIM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ASRQYIM PDB 2LFV http://www.ebi.ac.uk/pdbe-srv/view/entry/2LFV PDBsum 2LFV http://www.ebi.ac.uk/pdbsum/2LFV PROSITE PS51724 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51724 PSORT swissprot:DAMX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DAMX_ECOLI PSORT-B swissprot:DAMX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DAMX_ECOLI PSORT2 swissprot:DAMX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DAMX_ECOLI Pfam PF05036 http://pfam.xfam.org/family/PF05036 Phobius swissprot:DAMX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DAMX_ECOLI ProteinModelPortal P11557 http://www.proteinmodelportal.org/query/uniprot/P11557 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19684127 http://www.ncbi.nlm.nih.gov/pubmed/19684127 PubMed 19880599 http://www.ncbi.nlm.nih.gov/pubmed/19880599 PubMed 23290046 http://www.ncbi.nlm.nih.gov/pubmed/23290046 PubMed 2549371 http://www.ncbi.nlm.nih.gov/pubmed/2549371 PubMed 7603433 http://www.ncbi.nlm.nih.gov/pubmed/7603433 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417847 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417847 RefSeq WP_000343215 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000343215 SMR P11557 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P11557 STRING 511145.b3388 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3388&targetmode=cogs STRING COG3266 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3266&targetmode=cogs SUPFAM SSF110997 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF110997 UniProtKB DAMX_ECOLI http://www.uniprot.org/uniprot/DAMX_ECOLI UniProtKB-AC P11557 http://www.uniprot.org/uniprot/P11557 charge swissprot:DAMX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DAMX_ECOLI eggNOG COG3266 http://eggnogapi.embl.de/nog_data/html/tree/COG3266 eggNOG ENOG4105EGB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EGB epestfind swissprot:DAMX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DAMX_ECOLI garnier swissprot:DAMX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DAMX_ECOLI helixturnhelix swissprot:DAMX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DAMX_ECOLI hmoment swissprot:DAMX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DAMX_ECOLI iep swissprot:DAMX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DAMX_ECOLI inforesidue swissprot:DAMX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DAMX_ECOLI octanol swissprot:DAMX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DAMX_ECOLI pepcoil swissprot:DAMX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DAMX_ECOLI pepdigest swissprot:DAMX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DAMX_ECOLI pepinfo swissprot:DAMX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DAMX_ECOLI pepnet swissprot:DAMX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DAMX_ECOLI pepstats swissprot:DAMX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DAMX_ECOLI pepwheel swissprot:DAMX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DAMX_ECOLI pepwindow swissprot:DAMX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DAMX_ECOLI sigcleave swissprot:DAMX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DAMX_ECOLI ## Database ID URL or Descriptions # AltName YJJG_ECOLI House-cleaning nucleotidase # AltName YJJG_ECOLI Non-canonical pyrimidine nucleotide phosphatase # AltName YJJG_ECOLI Nucleoside 5'-monophosphate phosphohydrolase # AltName YJJG_ECOLI dUMP phosphatase # BIOPHYSICOCHEMICAL PROPERTIES YJJG_ECOLI Kinetic parameters KM=0.51 mM for 5'-dTMP (in the presence of Mn(2+)) {ECO 0000269|PubMed 15489502, ECO 0000269|PubMed 17286574}; KM=2.14 mM for 5'-dTMP (in the presence of 5 mM Mg(2+) and 0.5 mM Mn(2+)) {ECO 0000269|PubMed 15489502, ECO 0000269|PubMed 17286574}; KM=0.66 mM for 5'-UMP (in the presence of Mn(2+)) {ECO 0000269|PubMed 15489502, ECO 0000269|PubMed 17286574}; KM=0.77 mM for 5'-dUMP (in the presence of Mn(2+)) {ECO 0000269|PubMed 15489502, ECO 0000269|PubMed 17286574}; KM=0.237 mM for 5-FdUMP (in the presence of 5 mM Mg(2+) and 0.5 mM Mn(2+)) {ECO 0000269|PubMed 15489502, ECO 0000269|PubMed 17286574}; KM=17.8 mM for pNPP (in the presence of Mg(2+)) {ECO 0000269|PubMed 15489502, ECO 0000269|PubMed 17286574}; Vmax=65.6 umol/min/mg enzyme with 5'-dTMP as substrate {ECO 0000269|PubMed 15489502, ECO 0000269|PubMed 17286574}; Vmax=73.9 umol/min/mg enzyme with 5'-UMP as substrate {ECO 0000269|PubMed 15489502, ECO 0000269|PubMed 17286574}; Vmax=46.3 umol/min/mg enzyme with 5'-dUMP as substrate {ECO 0000269|PubMed 15489502, ECO 0000269|PubMed 17286574}; Vmax=8.86 umol/min/mg enzyme with pNPP as substrate {ECO 0000269|PubMed 15489502, ECO 0000269|PubMed 17286574}; Note=The catalytic efficiency is 15-fold higher with 5-fluoro- 2'-deoxyuridine monophosphate (5-FdUMP) than with 5'-dUMP as substrate.; pH dependence Optimum pH is 7.5. {ECO 0000269|PubMed 15489502}; # BioGrid 4262174 7 # CATALYTIC ACTIVITY YJJG_ECOLI A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate. {ECO 0000269|PubMed 15489502, ECO 0000269|PubMed 17286574}. # COFACTOR YJJG_ECOLI Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 15489502}; Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 15489502}; Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000269|PubMed 15489502}; Note=Divalent metal cation. Highest activity with Mn(2+) followed by Mg(2+) and Co(2+). {ECO 0000269|PubMed 15489502}; # DISRUPTION PHENOTYPE YJJG_ECOLI Cells lacking this gene become highly sensitive to toxic non-canonical pyrimidine derivatives such as 5- fluoro-2'-deoxyuridine (5-FdUMP); the growth is completely blocked. Disruption of yjjG in a thyA mutant blocks the utilization of thymine but not that of thymidine for growth. {ECO 0000269|PubMed 17189366, ECO 0000269|PubMed 17286574}. # ENZYME REGULATION YJJG_ECOLI In contrast to nucleotidases from other families, is not inhibited by ribo- and deoxyribonucleoside di- and triphosphates. # EcoGene EG12115 yjjG # FUNCTION YJJG_ECOLI Nucleotidase that shows high phosphatase activity toward non-canonical pyrimidine nucleotides and three canonical nucleoside 5'-monophosphates (UMP, dUMP, and dTMP), and very low activity against TDP, IMP, UDP, GMP, dGMP, AMP, dAMP, and 6- phosphogluconate. Appears to function as a house-cleaning nucleotidase in vivo, since the general nucleotidase activity of YjjG allows it to protect cells against non-canonical pyrimidine derivatives such as 5-fluoro-2'-deoxyuridine, 5-fluorouridine, 5- fluoroorotate, 5-fluorouracil, and 5-aza-2'-deoxycytidine, and prevents the incorporation of potentially mutagenic nucleotides into DNA. Its dUMP phosphatase activity that catalyzes the hydrolysis of dUMP to deoxyuridine is necessary for thymine utilization via the thymine salvage pathway. Is strictly specific to substrates with 5'-phosphates and shows no activity against nucleoside 2'- or 3'-monophosphates. {ECO 0000269|PubMed 15489502, ECO 0000269|PubMed 17189366, ECO 0000269|PubMed 17286574}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0000166 nucleotide binding; IEA:UniProtKB-KW. # GO_function GO:0008253 5'-nucleotidase activity; IDA:EcoCyc. # GO_function GO:0016791 phosphatase activity; IDA:EcoliWiki. # GO_function GO:0030145 manganese ion binding; IDA:EcoCyc. # GO_process GO:0009410 response to xenobiotic stimulus; IMP:EcoCyc. # GO_process GO:0019859 thymine metabolic process; IGI:EcoCyc. # GO_process GO:0043100 pyrimidine nucleobase salvage; IGI:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.150.240 -; 1. # Gene3D 3.40.50.1000 -; 1. # InterPro IPR006439 HAD-SF_hydro_IA # InterPro IPR011951 HAD-SF_hydro_IA_YjjG/YfnB # InterPro IPR023198 PGP_dom2 # InterPro IPR023214 HAD-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00240 Pyrimidine metabolism # KEGG_Pathway ko00760 Nicotinate and nicotinamide metabolism # Organism YJJG_ECOLI Escherichia coli (strain K12) # PATRIC 32124358 VBIEscCol129921_4519 # PIR S56598 S56598 # Pfam PF13419 HAD_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJJG_ECOLI Pyrimidine 5'-nucleotidase YjjG # RefSeq NP_418791 NC_000913.3 # RefSeq WP_000870710 NZ_LN832404.1 # SIMILARITY Belongs to the HAD-like hydrolase superfamily. YjjG family. {ECO 0000305}. # SUBCELLULAR LOCATION YJJG_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Monomer, homodimer and possibly homotetramer in solution. {ECO:0000269|PubMed 15489502}. # SUPFAM SSF56784 SSF56784 # TIGRFAMs TIGR01509 HAD-SF-IA-v3 # TIGRFAMs TIGR01549 HAD-SF-IA-v1 # TIGRFAMs TIGR02254 YjjG/YfnB # eggNOG COG1011 LUCA # eggNOG ENOG4105PAD Bacteria BLAST swissprot:YJJG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJJG_ECOLI BioCyc ECOL316407:JW4336-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4336-MONOMER BioCyc EcoCyc:EG12115-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12115-MONOMER BioCyc MetaCyc:EG12115-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12115-MONOMER COG COG1011 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1011 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M411023200 http://dx.doi.org/10.1074/jbc.M411023200 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1111/j.1574-6968.2007.00646.x http://dx.doi.org/10.1111/j.1574-6968.2007.00646.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01645-06 http://dx.doi.org/10.1128/JB.01645-06 EC_number EC:3.1.3.5 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.5 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D17724 http://www.ebi.ac.uk/ena/data/view/D17724 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL Z26313 http://www.ebi.ac.uk/ena/data/view/Z26313 ENZYME 3.1.3.5 http://enzyme.expasy.org/EC/3.1.3.5 EchoBASE EB2038 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2038 EcoGene EG12115 http://www.ecogene.org/geneInfo.php?eg_id=EG12115 EnsemblBacteria AAC77327 http://www.ensemblgenomes.org/id/AAC77327 EnsemblBacteria AAC77327 http://www.ensemblgenomes.org/id/AAC77327 EnsemblBacteria BAE78362 http://www.ensemblgenomes.org/id/BAE78362 EnsemblBacteria BAE78362 http://www.ensemblgenomes.org/id/BAE78362 EnsemblBacteria BAE78362 http://www.ensemblgenomes.org/id/BAE78362 EnsemblBacteria b4374 http://www.ensemblgenomes.org/id/b4374 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000166 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000166 GO_function GO:0008253 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008253 GO_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_process GO:0009410 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009410 GO_process GO:0019859 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019859 GO_process GO:0043100 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043100 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.150.240 http://www.cathdb.info/version/latest/superfamily/1.10.150.240 Gene3D 3.40.50.1000 http://www.cathdb.info/version/latest/superfamily/3.40.50.1000 GeneID 948899 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948899 HOGENOM HOG000248345 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000248345&db=HOGENOM6 InParanoid P0A8Y1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8Y1 IntEnz 3.1.3.5 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.5 InterPro IPR006439 http://www.ebi.ac.uk/interpro/entry/IPR006439 InterPro IPR011951 http://www.ebi.ac.uk/interpro/entry/IPR011951 InterPro IPR023198 http://www.ebi.ac.uk/interpro/entry/IPR023198 InterPro IPR023214 http://www.ebi.ac.uk/interpro/entry/IPR023214 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4336 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4336 KEGG_Gene eco:b4374 http://www.genome.jp/dbget-bin/www_bget?eco:b4374 KEGG_Orthology KO:K08723 http://www.genome.jp/dbget-bin/www_bget?KO:K08723 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Pathway ko00760 http://www.genome.jp/kegg-bin/show_pathway?ko00760 KEGG_Reaction rn:R00183 http://www.genome.jp/dbget-bin/www_bget?rn:R00183 KEGG_Reaction rn:R00511 http://www.genome.jp/dbget-bin/www_bget?rn:R00511 KEGG_Reaction rn:R00963 http://www.genome.jp/dbget-bin/www_bget?rn:R00963 KEGG_Reaction rn:R01126 http://www.genome.jp/dbget-bin/www_bget?rn:R01126 KEGG_Reaction rn:R01227 http://www.genome.jp/dbget-bin/www_bget?rn:R01227 KEGG_Reaction rn:R01569 http://www.genome.jp/dbget-bin/www_bget?rn:R01569 KEGG_Reaction rn:R01664 http://www.genome.jp/dbget-bin/www_bget?rn:R01664 KEGG_Reaction rn:R01968 http://www.genome.jp/dbget-bin/www_bget?rn:R01968 KEGG_Reaction rn:R02088 http://www.genome.jp/dbget-bin/www_bget?rn:R02088 KEGG_Reaction rn:R02323 http://www.genome.jp/dbget-bin/www_bget?rn:R02323 KEGG_Reaction rn:R02719 http://www.genome.jp/dbget-bin/www_bget?rn:R02719 KEGG_Reaction rn:R03346 http://www.genome.jp/dbget-bin/www_bget?rn:R03346 OMA PDARIFD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PDARIFD PSORT swissprot:YJJG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJJG_ECOLI PSORT-B swissprot:YJJG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJJG_ECOLI PSORT2 swissprot:YJJG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJJG_ECOLI Pfam PF13419 http://pfam.xfam.org/family/PF13419 Phobius swissprot:YJJG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJJG_ECOLI PhylomeDB P0A8Y1 http://phylomedb.org/?seqid=P0A8Y1 ProteinModelPortal P0A8Y1 http://www.proteinmodelportal.org/query/uniprot/P0A8Y1 PubMed 15489502 http://www.ncbi.nlm.nih.gov/pubmed/15489502 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17189366 http://www.ncbi.nlm.nih.gov/pubmed/17189366 PubMed 17286574 http://www.ncbi.nlm.nih.gov/pubmed/17286574 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418791 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418791 RefSeq WP_000870710 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000870710 SMR P0A8Y1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8Y1 STRING 511145.b4374 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4374&targetmode=cogs STRING COG1011 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1011&targetmode=cogs SUPFAM SSF56784 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784 TIGRFAMs TIGR01509 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01509 TIGRFAMs TIGR01549 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01549 TIGRFAMs TIGR02254 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02254 UniProtKB YJJG_ECOLI http://www.uniprot.org/uniprot/YJJG_ECOLI UniProtKB-AC P0A8Y1 http://www.uniprot.org/uniprot/P0A8Y1 charge swissprot:YJJG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJJG_ECOLI eggNOG COG1011 http://eggnogapi.embl.de/nog_data/html/tree/COG1011 eggNOG ENOG4105PAD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105PAD epestfind swissprot:YJJG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJJG_ECOLI garnier swissprot:YJJG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJJG_ECOLI helixturnhelix swissprot:YJJG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJJG_ECOLI hmoment swissprot:YJJG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJJG_ECOLI iep swissprot:YJJG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJJG_ECOLI inforesidue swissprot:YJJG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJJG_ECOLI octanol swissprot:YJJG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJJG_ECOLI pepcoil swissprot:YJJG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJJG_ECOLI pepdigest swissprot:YJJG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJJG_ECOLI pepinfo swissprot:YJJG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJJG_ECOLI pepnet swissprot:YJJG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJJG_ECOLI pepstats swissprot:YJJG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJJG_ECOLI pepwheel swissprot:YJJG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJJG_ECOLI pepwindow swissprot:YJJG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJJG_ECOLI sigcleave swissprot:YJJG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJJG_ECOLI ## Database ID URL or Descriptions # BioGrid 4260197 176 # EcoGene EG13774 yncD # FUNCTION YNCD_ECOLI Probable receptor, TonB-dependent. # GO_component GO:0009279 cell outer membrane; IBA:GO_Central. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0004872 receptor activity; IEA:InterPro. # GO_function GO:0005506 iron ion binding; IEA:InterPro. # GO_function GO:0015344 siderophore uptake transmembrane transporter activity; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # Gene3D 2.170.130.10 -; 1. # Gene3D 2.40.170.20 -; 1. # IntAct P76115 3 # InterPro IPR000531 TonB-dep_rcpt_b-brl # InterPro IPR010105 TonB_sidphr_rcpt # InterPro IPR012910 Plug_dom # KEGG_Brite ko02000 Transporters # Organism YNCD_ECOLI Escherichia coli (strain K12) # PATRIC 32118194 VBIEscCol129921_1517 # PIR F64897 F64897 # Pfam PF00593 TonB_dep_Rec # Pfam PF07715 Plug # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNCD_ECOLI Probable TonB-dependent receptor YncD # RefSeq NP_415968 NC_000913.3 # RefSeq WP_000689363 NZ_LN832404.1 # SIMILARITY Belongs to the TonB-dependent receptor family. {ECO 0000305}. # SUBCELLULAR LOCATION YNCD_ECOLI Cell outer membrane {ECO 0000305}; Peripheral membrane protein {ECO 0000305}. # TCDB 1.B.14.9 the outer membrane receptor (omr) family # TCDB 1.B.22.1 the outer bacterial membrane secretin (secretin) family # TIGRFAMs TIGR01783 TonB-siderophor # eggNOG COG1629 LUCA # eggNOG ENOG4105CHB Bacteria BLAST swissprot:YNCD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNCD_ECOLI BioCyc ECOL316407:JW1446-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1446-MONOMER BioCyc EcoCyc:G6762-MONOMER http://biocyc.org/getid?id=EcoCyc:G6762-MONOMER COG COG1629 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1629 DIP DIP-12750N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12750N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3536 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3536 EcoGene EG13774 http://www.ecogene.org/geneInfo.php?eg_id=EG13774 EnsemblBacteria AAC74533 http://www.ensemblgenomes.org/id/AAC74533 EnsemblBacteria AAC74533 http://www.ensemblgenomes.org/id/AAC74533 EnsemblBacteria BAE76444 http://www.ensemblgenomes.org/id/BAE76444 EnsemblBacteria BAE76444 http://www.ensemblgenomes.org/id/BAE76444 EnsemblBacteria BAE76444 http://www.ensemblgenomes.org/id/BAE76444 EnsemblBacteria b1451 http://www.ensemblgenomes.org/id/b1451 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0004872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004872 GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0015344 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015344 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 2.170.130.10 http://www.cathdb.info/version/latest/superfamily/2.170.130.10 Gene3D 2.40.170.20 http://www.cathdb.info/version/latest/superfamily/2.40.170.20 GeneID 946015 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946015 HOGENOM HOG000120630 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120630&db=HOGENOM6 InParanoid P76115 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76115 IntAct P76115 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76115* InterPro IPR000531 http://www.ebi.ac.uk/interpro/entry/IPR000531 InterPro IPR010105 http://www.ebi.ac.uk/interpro/entry/IPR010105 InterPro IPR012910 http://www.ebi.ac.uk/interpro/entry/IPR012910 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1446 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1446 KEGG_Gene eco:b1451 http://www.genome.jp/dbget-bin/www_bget?eco:b1451 KEGG_Orthology KO:K02014 http://www.genome.jp/dbget-bin/www_bget?KO:K02014 OMA TYRTNVC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TYRTNVC PSORT swissprot:YNCD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNCD_ECOLI PSORT-B swissprot:YNCD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNCD_ECOLI PSORT2 swissprot:YNCD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNCD_ECOLI Pfam PF00593 http://pfam.xfam.org/family/PF00593 Pfam PF07715 http://pfam.xfam.org/family/PF07715 Phobius swissprot:YNCD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNCD_ECOLI PhylomeDB P76115 http://phylomedb.org/?seqid=P76115 ProteinModelPortal P76115 http://www.proteinmodelportal.org/query/uniprot/P76115 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415968 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415968 RefSeq WP_000689363 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000689363 STRING 511145.b1451 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1451&targetmode=cogs STRING COG1629 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1629&targetmode=cogs TCDB 1.B.14.9 http://www.tcdb.org/search/result.php?tc=1.B.14.9 TCDB 1.B.22.1 http://www.tcdb.org/search/result.php?tc=1.B.22.1 TIGRFAMs TIGR01783 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01783 UniProtKB YNCD_ECOLI http://www.uniprot.org/uniprot/YNCD_ECOLI UniProtKB-AC P76115 http://www.uniprot.org/uniprot/P76115 charge swissprot:YNCD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNCD_ECOLI eggNOG COG1629 http://eggnogapi.embl.de/nog_data/html/tree/COG1629 eggNOG ENOG4105CHB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CHB epestfind swissprot:YNCD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNCD_ECOLI garnier swissprot:YNCD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNCD_ECOLI helixturnhelix swissprot:YNCD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNCD_ECOLI hmoment swissprot:YNCD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNCD_ECOLI iep swissprot:YNCD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNCD_ECOLI inforesidue swissprot:YNCD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNCD_ECOLI octanol swissprot:YNCD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNCD_ECOLI pepcoil swissprot:YNCD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNCD_ECOLI pepdigest swissprot:YNCD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNCD_ECOLI pepinfo swissprot:YNCD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNCD_ECOLI pepnet swissprot:YNCD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNCD_ECOLI pepstats swissprot:YNCD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNCD_ECOLI pepwheel swissprot:YNCD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNCD_ECOLI pepwindow swissprot:YNCD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNCD_ECOLI sigcleave swissprot:YNCD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNCD_ECOLI ## Database ID URL or Descriptions # BioGrid 4260321 11 # EcoGene EG14010 ynjH # InterPro IPR009971 DUF1496 # Organism YNJH_ECOLI Escherichia coli (strain K12) # PATRIC 32118831 VBIEscCol129921_1833 # PIR H64935 H64935 # Pfam PF07383 DUF1496 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNJH_ECOLI Uncharacterized protein YnjH # RefSeq NP_416274 NC_000913.3 # RefSeq WP_000085240 NZ_LN832404.1 # eggNOG ENOG4105MTM Bacteria # eggNOG ENOG4111UQ2 LUCA BLAST swissprot:YNJH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNJH_ECOLI BioCyc ECOL316407:JW1749-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1749-MONOMER BioCyc EcoCyc:G6955-MONOMER http://biocyc.org/getid?id=EcoCyc:G6955-MONOMER DIP DIP-12784N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12784N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3766 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3766 EcoGene EG14010 http://www.ecogene.org/geneInfo.php?eg_id=EG14010 EnsemblBacteria AAC74830 http://www.ensemblgenomes.org/id/AAC74830 EnsemblBacteria AAC74830 http://www.ensemblgenomes.org/id/AAC74830 EnsemblBacteria BAE76523 http://www.ensemblgenomes.org/id/BAE76523 EnsemblBacteria BAE76523 http://www.ensemblgenomes.org/id/BAE76523 EnsemblBacteria BAE76523 http://www.ensemblgenomes.org/id/BAE76523 EnsemblBacteria b1760 http://www.ensemblgenomes.org/id/b1760 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946279 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946279 HOGENOM HOG000121119 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000121119&db=HOGENOM6 InterPro IPR009971 http://www.ebi.ac.uk/interpro/entry/IPR009971 KEGG_Gene ecj:JW1749 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1749 KEGG_Gene eco:b1760 http://www.genome.jp/dbget-bin/www_bget?eco:b1760 OMA QCCIYQD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QCCIYQD PSORT swissprot:YNJH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNJH_ECOLI PSORT-B swissprot:YNJH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNJH_ECOLI PSORT2 swissprot:YNJH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNJH_ECOLI Pfam PF07383 http://pfam.xfam.org/family/PF07383 Phobius swissprot:YNJH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNJH_ECOLI ProteinModelPortal P76227 http://www.proteinmodelportal.org/query/uniprot/P76227 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416274 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416274 RefSeq WP_000085240 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000085240 STRING 511145.b1760 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1760&targetmode=cogs UniProtKB YNJH_ECOLI http://www.uniprot.org/uniprot/YNJH_ECOLI UniProtKB-AC P76227 http://www.uniprot.org/uniprot/P76227 charge swissprot:YNJH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNJH_ECOLI eggNOG ENOG4105MTM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105MTM eggNOG ENOG4111UQ2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111UQ2 epestfind swissprot:YNJH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNJH_ECOLI garnier swissprot:YNJH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNJH_ECOLI helixturnhelix swissprot:YNJH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNJH_ECOLI hmoment swissprot:YNJH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNJH_ECOLI iep swissprot:YNJH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNJH_ECOLI inforesidue swissprot:YNJH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNJH_ECOLI octanol swissprot:YNJH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNJH_ECOLI pepcoil swissprot:YNJH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNJH_ECOLI pepdigest swissprot:YNJH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNJH_ECOLI pepinfo swissprot:YNJH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNJH_ECOLI pepnet swissprot:YNJH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNJH_ECOLI pepstats swissprot:YNJH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNJH_ECOLI pepwheel swissprot:YNJH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNJH_ECOLI pepwindow swissprot:YNJH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNJH_ECOLI sigcleave swissprot:YNJH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNJH_ECOLI ## Database ID URL or Descriptions # AltName DSBD_ECOLI C-type cytochrome biogenesis protein CycZ # AltName DSBD_ECOLI Inner membrane copper tolerance protein # AltName DSBD_ECOLI Protein-disulfide reductase # BioGrid 4262691 1010 # CATALYTIC ACTIVITY DSBD_ECOLI Protein dithiol + NAD(P)(+) = protein disulfide + NAD(P)H. # EcoGene EG12178 dipZ # FUNCTION DSBD_ECOLI Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm, thereby maintaining the active site of DsbC, DsbE and DsbG in a reduced state. This transfer involves a cascade of disulfide bond formation and reduction steps. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoliWiki. # GO_component GO:0009898 cytoplasmic side of plasma membrane; IDA:EcoCyc. # GO_function GO:0009055 electron carrier activity; IEA:UniProtKB-HAMAP. # GO_function GO:0015035 protein disulfide oxidoreductase activity; IMP:EcoCyc. # GO_function GO:0016491 oxidoreductase activity; IDA:EcoliWiki. # GO_function GO:0022865 transmembrane electron transfer carrier; IDA:EcoCyc. # GO_function GO:0047134 protein-disulfide reductase activity; IEA:UniProtKB-HAMAP. # GO_process GO:0017004 cytochrome complex assembly; IMP:EcoliWiki. # GO_process GO:0042493 response to drug; IMP:EcoliWiki. # GO_process GO:0045454 cell redox homeostasis; IMP:EcoCyc. # GO_process GO:0055114 oxidation-reduction process; IDA:EcoCyc. # GO_process GO:0071502 cellular response to temperature stimulus; IMP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0008150 biological_process # GOslim_process GO:0042592 homeostatic process # Gene3D 2.60.40.1250 -; 1. # Gene3D 3.40.30.10 -; 1. # HAMAP MF_00399 DbsD # InterPro IPR003834 Cyt_c_assmbl_TM_dom # InterPro IPR012336 Thioredoxin-like_fold # InterPro IPR013766 Thioredoxin_domain # InterPro IPR017937 Thioredoxin_CS # InterPro IPR022910 Thiol_diS_interchange_DbsD # InterPro IPR028250 DsbDN # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03110 Chaperones and folding catalysts # MISCELLANEOUS DSBD_ECOLI The consequences of replacement of the cysteines with alanines were found to depend on the conditions tested and on the reporter system used for the analysis, and then differ depending on the references. # Organism DSBD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR32234:SF0 PTHR32234:SF0 # PATRIC 32123839 VBIEscCol129921_4267 # PDB 1JPE X-ray; 1.90 A; A=20-151 # PDB 1JZD X-ray; 2.30 A; C=20-151 # PDB 1L6P X-ray; 1.65 A; A=20-144 # PDB 1VRS X-ray; 2.85 A; A/B/C=20-162, D/E/F=438-565 # PDB 1Z5Y X-ray; 1.94 A; D=20-162 # PDB 2FWE X-ray; 1.65 A; A=438-565 # PDB 2FWF X-ray; 1.30 A; A=438-565 # PDB 2FWG X-ray; 1.10 A; A=438-565 # PDB 2FWH X-ray; 0.99 A; A=438-565 # PDB 3PFU X-ray; 1.80 A; A=21-151 # PDB 4IP1 X-ray; 2.47 A; A=444-565 # PDB 4IP6 X-ray; 2.23 A; A=444-565 # PIR S56364 S56364 # PROSITE PS00194 THIOREDOXIN_1 # PROSITE PS51352 THIOREDOXIN_2 # Pfam PF02683 DsbD # Pfam PF11412 DsbC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Thiol disulfide interchange protein DsbD # RefSeq NP_418559 NC_000913.3 # RefSeq WP_000068922 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA54781.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA85375.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the thioredoxin family. DsbD subfamily. {ECO 0000305}. # SIMILARITY Contains 1 thioredoxin domain. {ECO 0000305}. # SUBCELLULAR LOCATION DSBD_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF52833 SSF52833 # SUPFAM SSF74863 SSF74863 # TCDB 5.A.1.1 the disulfide bond oxidoreductase d (dsbd) family # eggNOG COG4232 LUCA # eggNOG ENOG4105CSG Bacteria BLAST swissprot:DSBD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DSBD_ECOLI BioCyc ECOL316407:JW5734-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5734-MONOMER BioCyc EcoCyc:DSBD-MONOMER http://biocyc.org/getid?id=EcoCyc:DSBD-MONOMER BioCyc MetaCyc:DSBD-MONOMER http://biocyc.org/getid?id=MetaCyc:DSBD-MONOMER COG COG0526 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0526 DIP DIP-9476N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9476N DOI 10.1016/0014-5793(94)01053-6 http://dx.doi.org/10.1016/0014-5793(94)01053-6 DOI 10.1016/S0092-8674(00)00180-X http://dx.doi.org/10.1016/S0092-8674(00)00180-X DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2000.01778.x http://dx.doi.org/10.1046/j.1365-2958.2000.01778.x DOI 10.1046/j.1365-2958.2000.01796.x http://dx.doi.org/10.1046/j.1365-2958.2000.01796.x DOI 10.1074/jbc.M009500200 http://dx.doi.org/10.1074/jbc.M009500200 DOI 10.1093/emboj/18.21.5963 http://dx.doi.org/10.1093/emboj/18.21.5963 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1111/j.1365-2958.1995.tb02286.x http://dx.doi.org/10.1111/j.1365-2958.1995.tb02286.x DOI 10.1111/j.1365-2958.1995.tb02287.x http://dx.doi.org/10.1111/j.1365-2958.1995.tb02287.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.8.1.8 http://www.genome.jp/dbget-bin/www_bget?EC:1.8.1.8 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X77707 http://www.ebi.ac.uk/ena/data/view/X77707 EMBL Z36905 http://www.ebi.ac.uk/ena/data/view/Z36905 ENZYME 1.8.1.8 http://enzyme.expasy.org/EC/1.8.1.8 EchoBASE EB2095 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2095 EcoGene EG12178 http://www.ecogene.org/geneInfo.php?eg_id=EG12178 EnsemblBacteria AAC77096 http://www.ensemblgenomes.org/id/AAC77096 EnsemblBacteria AAC77096 http://www.ensemblgenomes.org/id/AAC77096 EnsemblBacteria BAE78138 http://www.ensemblgenomes.org/id/BAE78138 EnsemblBacteria BAE78138 http://www.ensemblgenomes.org/id/BAE78138 EnsemblBacteria BAE78138 http://www.ensemblgenomes.org/id/BAE78138 EnsemblBacteria b4136 http://www.ensemblgenomes.org/id/b4136 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0009898 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009898 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0015035 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015035 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0022865 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022865 GO_function GO:0047134 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047134 GO_process GO:0017004 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017004 GO_process GO:0042493 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493 GO_process GO:0045454 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045454 GO_process GO:0055114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114 GO_process GO:0071502 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071502 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 Gene3D 2.60.40.1250 http://www.cathdb.info/version/latest/superfamily/2.60.40.1250 Gene3D 3.40.30.10 http://www.cathdb.info/version/latest/superfamily/3.40.30.10 GeneID 948649 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948649 HAMAP MF_00399 http://hamap.expasy.org/unirule/MF_00399 HOGENOM HOG000254981 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000254981&db=HOGENOM6 InParanoid P36655 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P36655 IntEnz 1.8.1.8 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.8.1.8 InterPro IPR003834 http://www.ebi.ac.uk/interpro/entry/IPR003834 InterPro IPR012336 http://www.ebi.ac.uk/interpro/entry/IPR012336 InterPro IPR013766 http://www.ebi.ac.uk/interpro/entry/IPR013766 InterPro IPR017937 http://www.ebi.ac.uk/interpro/entry/IPR017937 InterPro IPR022910 http://www.ebi.ac.uk/interpro/entry/IPR022910 InterPro IPR028250 http://www.ebi.ac.uk/interpro/entry/IPR028250 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW5734 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5734 KEGG_Gene eco:b4136 http://www.genome.jp/dbget-bin/www_bget?eco:b4136 KEGG_Orthology KO:K04084 http://www.genome.jp/dbget-bin/www_bget?KO:K04084 OMA MEKQVFG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MEKQVFG PANTHER PTHR32234:SF0 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32234:SF0 PDB 1JPE http://www.ebi.ac.uk/pdbe-srv/view/entry/1JPE PDB 1JZD http://www.ebi.ac.uk/pdbe-srv/view/entry/1JZD PDB 1L6P http://www.ebi.ac.uk/pdbe-srv/view/entry/1L6P PDB 1VRS http://www.ebi.ac.uk/pdbe-srv/view/entry/1VRS PDB 1Z5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/1Z5Y PDB 2FWE http://www.ebi.ac.uk/pdbe-srv/view/entry/2FWE PDB 2FWF http://www.ebi.ac.uk/pdbe-srv/view/entry/2FWF PDB 2FWG http://www.ebi.ac.uk/pdbe-srv/view/entry/2FWG PDB 2FWH http://www.ebi.ac.uk/pdbe-srv/view/entry/2FWH PDB 3PFU http://www.ebi.ac.uk/pdbe-srv/view/entry/3PFU PDB 4IP1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4IP1 PDB 4IP6 http://www.ebi.ac.uk/pdbe-srv/view/entry/4IP6 PDBsum 1JPE http://www.ebi.ac.uk/pdbsum/1JPE PDBsum 1JZD http://www.ebi.ac.uk/pdbsum/1JZD PDBsum 1L6P http://www.ebi.ac.uk/pdbsum/1L6P PDBsum 1VRS http://www.ebi.ac.uk/pdbsum/1VRS PDBsum 1Z5Y http://www.ebi.ac.uk/pdbsum/1Z5Y PDBsum 2FWE http://www.ebi.ac.uk/pdbsum/2FWE PDBsum 2FWF http://www.ebi.ac.uk/pdbsum/2FWF PDBsum 2FWG http://www.ebi.ac.uk/pdbsum/2FWG PDBsum 2FWH http://www.ebi.ac.uk/pdbsum/2FWH PDBsum 3PFU http://www.ebi.ac.uk/pdbsum/3PFU PDBsum 4IP1 http://www.ebi.ac.uk/pdbsum/4IP1 PDBsum 4IP6 http://www.ebi.ac.uk/pdbsum/4IP6 PROSITE PS00194 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00194 PROSITE PS51352 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51352 PSORT swissprot:DSBD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DSBD_ECOLI PSORT-B swissprot:DSBD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DSBD_ECOLI PSORT2 swissprot:DSBD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DSBD_ECOLI Pfam PF02683 http://pfam.xfam.org/family/PF02683 Pfam PF11412 http://pfam.xfam.org/family/PF11412 Phobius swissprot:DSBD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DSBD_ECOLI PhylomeDB P36655 http://phylomedb.org/?seqid=P36655 ProteinModelPortal P36655 http://www.proteinmodelportal.org/query/uniprot/P36655 PubMed 10545108 http://www.ncbi.nlm.nih.gov/pubmed/10545108 PubMed 10712691 http://www.ncbi.nlm.nih.gov/pubmed/10712691 PubMed 10760137 http://www.ncbi.nlm.nih.gov/pubmed/10760137 PubMed 11085993 http://www.ncbi.nlm.nih.gov/pubmed/11085993 PubMed 11114333 http://www.ncbi.nlm.nih.gov/pubmed/11114333 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 7623666 http://www.ncbi.nlm.nih.gov/pubmed/7623666 PubMed 7623667 http://www.ncbi.nlm.nih.gov/pubmed/7623667 PubMed 7628442 http://www.ncbi.nlm.nih.gov/pubmed/7628442 PubMed 7957865 http://www.ncbi.nlm.nih.gov/pubmed/7957865 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418559 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418559 RefSeq WP_000068922 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000068922 SMR P36655 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P36655 STRING 511145.b4136 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4136&targetmode=cogs STRING COG0526 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0526&targetmode=cogs SUPFAM SSF52833 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52833 SUPFAM SSF74863 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF74863 TCDB 5.A.1.1 http://www.tcdb.org/search/result.php?tc=5.A.1.1 UniProtKB DSBD_ECOLI http://www.uniprot.org/uniprot/DSBD_ECOLI UniProtKB-AC P36655 http://www.uniprot.org/uniprot/P36655 charge swissprot:DSBD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DSBD_ECOLI eggNOG COG4232 http://eggnogapi.embl.de/nog_data/html/tree/COG4232 eggNOG ENOG4105CSG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CSG epestfind swissprot:DSBD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DSBD_ECOLI garnier swissprot:DSBD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DSBD_ECOLI helixturnhelix swissprot:DSBD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DSBD_ECOLI hmoment swissprot:DSBD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DSBD_ECOLI iep swissprot:DSBD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DSBD_ECOLI inforesidue swissprot:DSBD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DSBD_ECOLI octanol swissprot:DSBD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DSBD_ECOLI pepcoil swissprot:DSBD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DSBD_ECOLI pepdigest swissprot:DSBD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DSBD_ECOLI pepinfo swissprot:DSBD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DSBD_ECOLI pepnet swissprot:DSBD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DSBD_ECOLI pepstats swissprot:DSBD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DSBD_ECOLI pepwheel swissprot:DSBD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DSBD_ECOLI pepwindow swissprot:DSBD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DSBD_ECOLI sigcleave swissprot:DSBD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DSBD_ECOLI ## Database ID URL or Descriptions # AltName 23S rRNA(m5U747)-methyltransferase {ECO:0000255|HAMAP-Rule MF_01012} # BRENDA 2.1.1.189 2026 # BioGrid 4259987 8 # CATALYTIC ACTIVITY RLMC_ECOLI S-adenosyl-L-methionine + uracil(747) in 23S rRNA = S-adenosyl-L-homocysteine + 5-methyluracil(747) in 23S rRNA. {ECO 0000255|HAMAP-Rule MF_01012, ECO 0000269|PubMed 12907714}. # EcoGene EG13427 rlmC # FUNCTION RLMC_ECOLI Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA. {ECO 0000255|HAMAP-Rule MF_01012, ECO 0000269|PubMed 12907714}. # GO_function GO:0005506 iron ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0016436 rRNA (uridine) methyltransferase activity; IMP:EcoCyc. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GO_function GO:0070041 rRNA (uridine-C5-)-methyltransferase activity; IEA:UniProtKB-HAMAP. # GO_process GO:0070475 rRNA base methylation; IMP:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008168 methyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.50.150 -; 1. # HAMAP MF_01012 23SrRNA_methyltr_RlmC # IntAct P75817 8 # InterPro IPR010280 U5_MeTrfase_fam # InterPro IPR011825 23SrRNA_MeTrfase_RlmC # InterPro IPR029063 SAM-dependent_MTases # InterPro IPR030390 MeTrfase_TrmA_AS # InterPro IPR030391 MeTrfase_TrmA_CS # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # Organism RLMC_ECOLI Escherichia coli (strain K12) # PATRIC 32116923 VBIEscCol129921_0887 # PIR C64824 C64824 # PROSITE PS01230 TRMA_1 # PROSITE PS01231 TRMA_2 # PROSITE PS51687 SAM_MT_RNA_M5U # Pfam PF05958 tRNA_U5-meth_tr # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 23S rRNA (uracil(747)-C(5))-methyltransferase RlmC {ECO:0000255|HAMAP-Rule MF_01012} # RefSeq NP_415380 NC_000913.3 # RefSeq WP_001149682 NZ_LN832404.1 # SIMILARITY Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily. {ECO:0000255|HAMAP-Rule MF_01012}. # SUPFAM SSF53335 SSF53335 # TIGRFAMs TIGR02085 meth_trns_rumB # eggNOG COG2265 LUCA # eggNOG ENOG4107SFS Bacteria BLAST swissprot:RLMC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RLMC_ECOLI BioCyc ECOL316407:JW0843-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0843-MONOMER BioCyc EcoCyc:G6449-MONOMER http://biocyc.org/getid?id=EcoCyc:G6449-MONOMER BioCyc MetaCyc:G6449-MONOMER http://biocyc.org/getid?id=MetaCyc:G6449-MONOMER COG COG2265 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2265 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/gkg657 http://dx.doi.org/10.1093/nar/gkg657 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.1.189 {ECO:0000255|HAMAP-Rule:MF_01012} http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.189 {ECO:0000255|HAMAP-Rule:MF_01012} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.1.1.189 {ECO:0000255|HAMAP-Rule:MF_01012} http://enzyme.expasy.org/EC/2.1.1.189 {ECO:0000255|HAMAP-Rule:MF_01012} EchoBASE EB3201 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3201 EcoGene EG13427 http://www.ecogene.org/geneInfo.php?eg_id=EG13427 EnsemblBacteria AAC73946 http://www.ensemblgenomes.org/id/AAC73946 EnsemblBacteria AAC73946 http://www.ensemblgenomes.org/id/AAC73946 EnsemblBacteria BAA35573 http://www.ensemblgenomes.org/id/BAA35573 EnsemblBacteria BAA35573 http://www.ensemblgenomes.org/id/BAA35573 EnsemblBacteria BAA35573 http://www.ensemblgenomes.org/id/BAA35573 EnsemblBacteria b0859 http://www.ensemblgenomes.org/id/b0859 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0016436 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016436 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_function GO:0070041 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070041 GO_process GO:0070475 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070475 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 GeneID 947260 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947260 HAMAP MF_01012 http://hamap.expasy.org/unirule/MF_01012 HOGENOM HOG000218547 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218547&db=HOGENOM6 InParanoid P75817 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75817 IntAct P75817 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75817* IntEnz 2.1.1.189 {ECO:0000255|HAMAP-Rule:MF_01012} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.189 {ECO:0000255|HAMAP-Rule:MF_01012} InterPro IPR010280 http://www.ebi.ac.uk/interpro/entry/IPR010280 InterPro IPR011825 http://www.ebi.ac.uk/interpro/entry/IPR011825 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 InterPro IPR030390 http://www.ebi.ac.uk/interpro/entry/IPR030390 InterPro IPR030391 http://www.ebi.ac.uk/interpro/entry/IPR030391 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW0843 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0843 KEGG_Gene eco:b0859 http://www.genome.jp/dbget-bin/www_bget?eco:b0859 KEGG_Orthology KO:K03212 http://www.genome.jp/dbget-bin/www_bget?KO:K03212 OMA NIQPIHM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NIQPIHM PROSITE PS01230 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01230 PROSITE PS01231 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01231 PROSITE PS51687 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51687 PSORT swissprot:RLMC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RLMC_ECOLI PSORT-B swissprot:RLMC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RLMC_ECOLI PSORT2 swissprot:RLMC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RLMC_ECOLI Pfam PF05958 http://pfam.xfam.org/family/PF05958 Phobius swissprot:RLMC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RLMC_ECOLI PhylomeDB P75817 http://phylomedb.org/?seqid=P75817 ProteinModelPortal P75817 http://www.proteinmodelportal.org/query/uniprot/P75817 PubMed 12907714 http://www.ncbi.nlm.nih.gov/pubmed/12907714 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415380 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415380 RefSeq WP_001149682 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001149682 STRING 511145.b0859 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0859&targetmode=cogs STRING COG2265 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2265&targetmode=cogs SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 TIGRFAMs TIGR02085 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02085 UniProtKB RLMC_ECOLI http://www.uniprot.org/uniprot/RLMC_ECOLI UniProtKB-AC P75817 http://www.uniprot.org/uniprot/P75817 charge swissprot:RLMC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RLMC_ECOLI eggNOG COG2265 http://eggnogapi.embl.de/nog_data/html/tree/COG2265 eggNOG ENOG4107SFS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107SFS epestfind swissprot:RLMC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RLMC_ECOLI garnier swissprot:RLMC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RLMC_ECOLI helixturnhelix swissprot:RLMC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RLMC_ECOLI hmoment swissprot:RLMC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RLMC_ECOLI iep swissprot:RLMC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RLMC_ECOLI inforesidue swissprot:RLMC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RLMC_ECOLI octanol swissprot:RLMC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RLMC_ECOLI pepcoil swissprot:RLMC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RLMC_ECOLI pepdigest swissprot:RLMC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RLMC_ECOLI pepinfo swissprot:RLMC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RLMC_ECOLI pepnet swissprot:RLMC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RLMC_ECOLI pepstats swissprot:RLMC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RLMC_ECOLI pepwheel swissprot:RLMC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RLMC_ECOLI pepwindow swissprot:RLMC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RLMC_ECOLI sigcleave swissprot:RLMC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RLMC_ECOLI ## Database ID URL or Descriptions # BioGrid 4262905 328 # EcoGene EG13441 lolE # FUNCTION LOLE_ECOLI Part of an ATP-dependent transport system LolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and of LolA. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0009276 Gram-negative-bacterium-type cell wall; IEA:InterPro. # GO_component GO:0043234 protein complex; IDA:EcoCyc. # GO_function GO:0042954 lipoprotein transporter activity; IDA:EcoCyc. # GO_process GO:0042953 lipoprotein transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005618 cell wall # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006810 transport # INTERACTION LOLE_ECOLI P0A912 pal; NbExp=2; IntAct=EBI-1125190, EBI-1124760; # IntAct P75958 7 # InterPro IPR003838 ABC_permease_dom # InterPro IPR011925 LolCE_TM # InterPro IPR011926 LolC/E_gammaproteobact # InterPro IPR025857 MacB_PCD # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00255 Lipoprotein-releasing system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism LOLE_ECOLI Escherichia coli (strain K12) # PATRIC 32117483 VBIEscCol129921_1164 # PIR C64856 C64856 # Pfam PF02687 FtsX # Pfam PF12704 MacB_PCD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LOLE_ECOLI Lipoprotein-releasing system transmembrane protein LolE # RefSeq NP_415636 NC_000913.3 # RefSeq WP_001251348 NZ_LN832404.1 # SIMILARITY Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION LOLE_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 3.A.1.125 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR02212 lolCE # TIGRFAMs TIGR02213 lolE_release # eggNOG COG4591 LUCA # eggNOG ENOG4105D60 Bacteria BLAST swissprot:LOLE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LOLE_ECOLI BioCyc ECOL316407:JW1104-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1104-MONOMER BioCyc EcoCyc:YCFW-MONOMER http://biocyc.org/getid?id=EcoCyc:YCFW-MONOMER COG COG4591 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4591 DOI 10.1038/35008635 http://dx.doi.org/10.1038/35008635 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3215 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3215 EcoGene EG13441 http://www.ecogene.org/geneInfo.php?eg_id=EG13441 EnsemblBacteria AAC74202 http://www.ensemblgenomes.org/id/AAC74202 EnsemblBacteria AAC74202 http://www.ensemblgenomes.org/id/AAC74202 EnsemblBacteria BAA35938 http://www.ensemblgenomes.org/id/BAA35938 EnsemblBacteria BAA35938 http://www.ensemblgenomes.org/id/BAA35938 EnsemblBacteria BAA35938 http://www.ensemblgenomes.org/id/BAA35938 EnsemblBacteria b1118 http://www.ensemblgenomes.org/id/b1118 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0009276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009276 GO_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GO_function GO:0042954 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042954 GO_process GO:0042953 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042953 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005618 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 945665 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945665 HOGENOM HOG000218040 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218040&db=HOGENOM6 InParanoid P75958 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75958 IntAct P75958 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75958* InterPro IPR003838 http://www.ebi.ac.uk/interpro/entry/IPR003838 InterPro IPR011925 http://www.ebi.ac.uk/interpro/entry/IPR011925 InterPro IPR011926 http://www.ebi.ac.uk/interpro/entry/IPR011926 InterPro IPR025857 http://www.ebi.ac.uk/interpro/entry/IPR025857 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1104 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1104 KEGG_Gene eco:b1118 http://www.genome.jp/dbget-bin/www_bget?eco:b1118 KEGG_Orthology KO:K09808 http://www.genome.jp/dbget-bin/www_bget?KO:K09808 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 MINT MINT-8401583 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8401583 OMA LNDYPQM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LNDYPQM PSORT swissprot:LOLE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LOLE_ECOLI PSORT-B swissprot:LOLE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LOLE_ECOLI PSORT2 swissprot:LOLE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LOLE_ECOLI Pfam PF02687 http://pfam.xfam.org/family/PF02687 Pfam PF12704 http://pfam.xfam.org/family/PF12704 Phobius swissprot:LOLE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LOLE_ECOLI PhylomeDB P75958 http://phylomedb.org/?seqid=P75958 ProteinModelPortal P75958 http://www.proteinmodelportal.org/query/uniprot/P75958 PubMed 10783239 http://www.ncbi.nlm.nih.gov/pubmed/10783239 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415636 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415636 RefSeq WP_001251348 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001251348 SMR P75958 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75958 STRING 511145.b1118 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1118&targetmode=cogs STRING COG4591 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4591&targetmode=cogs TCDB 3.A.1.125 http://www.tcdb.org/search/result.php?tc=3.A.1.125 TIGRFAMs TIGR02212 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02212 TIGRFAMs TIGR02213 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02213 UniProtKB LOLE_ECOLI http://www.uniprot.org/uniprot/LOLE_ECOLI UniProtKB-AC P75958 http://www.uniprot.org/uniprot/P75958 charge swissprot:LOLE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LOLE_ECOLI eggNOG COG4591 http://eggnogapi.embl.de/nog_data/html/tree/COG4591 eggNOG ENOG4105D60 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D60 epestfind swissprot:LOLE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LOLE_ECOLI garnier swissprot:LOLE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LOLE_ECOLI helixturnhelix swissprot:LOLE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LOLE_ECOLI hmoment swissprot:LOLE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LOLE_ECOLI iep swissprot:LOLE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LOLE_ECOLI inforesidue swissprot:LOLE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LOLE_ECOLI octanol swissprot:LOLE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LOLE_ECOLI pepcoil swissprot:LOLE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LOLE_ECOLI pepdigest swissprot:LOLE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LOLE_ECOLI pepinfo swissprot:LOLE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LOLE_ECOLI pepnet swissprot:LOLE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LOLE_ECOLI pepstats swissprot:LOLE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LOLE_ECOLI pepwheel swissprot:LOLE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LOLE_ECOLI pepwindow swissprot:LOLE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LOLE_ECOLI sigcleave swissprot:LOLE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LOLE_ECOLI ## Database ID URL or Descriptions # BioGrid 4262958 15 # EcoGene EG12956 cutC # FUNCTION CUTC_ECOLI Involved in copper homeostasis. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0005507 copper ion binding; IEA:InterPro. # GO_process GO:0006878 cellular copper ion homeostasis; IGI:EcoliWiki. # GO_process GO:0046688 response to copper ion; IGI:EcoliWiki. # GO_process GO:0055070 copper ion homeostasis; IGI:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0042592 homeostatic process # Gene3D 3.20.20.380 -; 1. # HAMAP MF_00795 CutC # IntAct P67826 6 # InterPro IPR005627 Cu_homeostasis_CutC # InterPro IPR023648 Cu_homeostasis_CutC_dom # Organism CUTC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR12598 PTHR12598 # PATRIC 32119073 VBIEscCol129921_1954 # PIR B64950 B64950 # Pfam PF03932 CutC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CUTC_ECOLI Copper homeostasis protein CutC # RefSeq WP_001185741 NZ_LN832404.1 # RefSeq YP_025309 NC_000913.3 # SIMILARITY Belongs to the CutC family. {ECO 0000305}. # SUBCELLULAR LOCATION CUTC_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Homodimer. {ECO 0000250}. # SUPFAM SSF110395 SSF110395 # TCDB 9.B.158.1 the cut copper homeostasis (cut) family # eggNOG COG3142 LUCA # eggNOG ENOG4106N3A Bacteria BLAST swissprot:CUTC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CUTC_ECOLI BioCyc ECOL316407:JW1863-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1863-MONOMER BioCyc EcoCyc:G7024-MONOMER http://biocyc.org/getid?id=EcoCyc:G7024-MONOMER COG COG3142 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3142 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L38618 http://www.ebi.ac.uk/ena/data/view/L38618 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2790 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2790 EcoGene EG12956 http://www.ecogene.org/geneInfo.php?eg_id=EG12956 EnsemblBacteria AAC74944 http://www.ensemblgenomes.org/id/AAC74944 EnsemblBacteria AAC74944 http://www.ensemblgenomes.org/id/AAC74944 EnsemblBacteria BAA15684 http://www.ensemblgenomes.org/id/BAA15684 EnsemblBacteria BAA15684 http://www.ensemblgenomes.org/id/BAA15684 EnsemblBacteria BAA15684 http://www.ensemblgenomes.org/id/BAA15684 EnsemblBacteria b1874 http://www.ensemblgenomes.org/id/b1874 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0005507 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005507 GO_process GO:0006878 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006878 GO_process GO:0046688 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046688 GO_process GO:0055070 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055070 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 Gene3D 3.20.20.380 http://www.cathdb.info/version/latest/superfamily/3.20.20.380 GeneID 2847756 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2847756 HAMAP MF_00795 http://hamap.expasy.org/unirule/MF_00795 HOGENOM HOG000100908 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000100908&db=HOGENOM6 InParanoid P67826 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P67826 IntAct P67826 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P67826* InterPro IPR005627 http://www.ebi.ac.uk/interpro/entry/IPR005627 InterPro IPR023648 http://www.ebi.ac.uk/interpro/entry/IPR023648 KEGG_Gene ecj:JW1863 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1863 KEGG_Gene eco:b1874 http://www.genome.jp/dbget-bin/www_bget?eco:b1874 KEGG_Orthology KO:K06201 http://www.genome.jp/dbget-bin/www_bget?KO:K06201 OMA RIELCAG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RIELCAG PANTHER PTHR12598 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12598 PSORT swissprot:CUTC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CUTC_ECOLI PSORT-B swissprot:CUTC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CUTC_ECOLI PSORT2 swissprot:CUTC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CUTC_ECOLI Pfam PF03932 http://pfam.xfam.org/family/PF03932 Phobius swissprot:CUTC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CUTC_ECOLI PhylomeDB P67826 http://phylomedb.org/?seqid=P67826 ProteinModelPortal P67826 http://www.proteinmodelportal.org/query/uniprot/P67826 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7635807 http://www.ncbi.nlm.nih.gov/pubmed/7635807 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001185741 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001185741 RefSeq YP_025309 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_025309 SMR P67826 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P67826 STRING 511145.b1874 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1874&targetmode=cogs STRING COG3142 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3142&targetmode=cogs SUPFAM SSF110395 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF110395 TCDB 9.B.158.1 http://www.tcdb.org/search/result.php?tc=9.B.158.1 UniProtKB CUTC_ECOLI http://www.uniprot.org/uniprot/CUTC_ECOLI UniProtKB-AC P67826 http://www.uniprot.org/uniprot/P67826 charge swissprot:CUTC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CUTC_ECOLI eggNOG COG3142 http://eggnogapi.embl.de/nog_data/html/tree/COG3142 eggNOG ENOG4106N3A http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106N3A epestfind swissprot:CUTC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CUTC_ECOLI garnier swissprot:CUTC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CUTC_ECOLI helixturnhelix swissprot:CUTC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CUTC_ECOLI hmoment swissprot:CUTC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CUTC_ECOLI iep swissprot:CUTC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CUTC_ECOLI inforesidue swissprot:CUTC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CUTC_ECOLI octanol swissprot:CUTC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CUTC_ECOLI pepcoil swissprot:CUTC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CUTC_ECOLI pepdigest swissprot:CUTC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CUTC_ECOLI pepinfo swissprot:CUTC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CUTC_ECOLI pepnet swissprot:CUTC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CUTC_ECOLI pepstats swissprot:CUTC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CUTC_ECOLI pepwheel swissprot:CUTC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CUTC_ECOLI pepwindow swissprot:CUTC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CUTC_ECOLI sigcleave swissprot:CUTC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CUTC_ECOLI ## Database ID URL or Descriptions # AltName PUR8_ECOLI Adenylosuccinase # BRENDA 4.3.2 2026 # BioGrid 4262847 274 # CATALYTIC ACTIVITY (S)-2-(5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1- (5-phospho-D-ribosyl)imidazole-4-carboxamide. {ECO:0000269|PubMed 17531264}. # CATALYTIC ACTIVITY N(6)-(1,2-dicarboxyethyl)AMP = fumarate + AMP. {ECO:0000269|PubMed 17531264}. # EcoGene EG11314 purB # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004018 N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity; IDA:EcoCyc. # GO_function GO:0070626 (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity; IBA:GO_Central. # GO_process GO:0006163 purine nucleotide metabolic process; IBA:GO_Central. # GO_process GO:0006189 'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0044208 'de novo' AMP biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0051262 protein tetramerization; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.275.10 -; 1. # IntAct P0AB89 11 # InterPro IPR000362 Fumarate_lyase_fam # InterPro IPR004769 Pur_lyase # InterPro IPR008948 L-Aspartase-like # InterPro IPR013539 PurB_C # InterPro IPR020557 Fumarate_lyase_CS # InterPro IPR022761 Fumarate_lyase_N # InterPro IPR024083 Fumarase/histidase_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00250 Alanine, aspartate and glutamate metabolism # Organism PUR8_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11444 PTHR11444 # PATHWAY Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP step 2/2. # PATHWAY Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5- amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate step 2/2. # PATRIC 32117511 VBIEscCol129921_1178 # PDB 2PTQ X-ray; 2.00 A; A/B=1-456 # PDB 2PTR X-ray; 1.85 A; A/B=1-456 # PDB 2PTS X-ray; 2.00 A; A=1-456 # PIR S19212 S19212 # PRINTS PR00149 FUMRATELYASE # PROSITE PS00163 FUMARATE_LYASES # Pfam PF00206 Lyase_1 # Pfam PF08328 ASL_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PUR8_ECOLI Adenylosuccinate lyase # RefSeq NP_415649 NC_000913.3 # RefSeq WP_000423742 NZ_LN832404.1 # SIMILARITY Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. {ECO 0000305}. # SUBUNIT Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site. {ECO:0000269|PubMed 17531264}. # SUPFAM SSF48557 SSF48557 # TIGRFAMs TIGR00928 purB # UniPathway UPA00074 UER00132 # UniPathway UPA00075 UER00336 # eggNOG COG0015 LUCA # eggNOG ENOG4107QTF Bacteria BLAST swissprot:PUR8_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PUR8_ECOLI BioCyc ECOL316407:JW1117-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1117-MONOMER BioCyc EcoCyc:ASL-MONOMER http://biocyc.org/getid?id=EcoCyc:ASL-MONOMER BioCyc MetaCyc:ASL-MONOMER http://biocyc.org/getid?id=MetaCyc:ASL-MONOMER COG COG0015 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0015 DIP DIP-10608N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10608N DOI 10.1016/j.jmb.2007.04.052 http://dx.doi.org/10.1016/j.jmb.2007.04.052 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.3.2.2 http://www.genome.jp/dbget-bin/www_bget?EC:4.3.2.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M74924 http://www.ebi.ac.uk/ena/data/view/M74924 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X59307 http://www.ebi.ac.uk/ena/data/view/X59307 ENZYME 4.3.2.2 http://enzyme.expasy.org/EC/4.3.2.2 EchoBASE EB1290 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1290 EcoGene EG11314 http://www.ecogene.org/geneInfo.php?eg_id=EG11314 EnsemblBacteria AAC74215 http://www.ensemblgenomes.org/id/AAC74215 EnsemblBacteria AAC74215 http://www.ensemblgenomes.org/id/AAC74215 EnsemblBacteria BAA35953 http://www.ensemblgenomes.org/id/BAA35953 EnsemblBacteria BAA35953 http://www.ensemblgenomes.org/id/BAA35953 EnsemblBacteria BAA35953 http://www.ensemblgenomes.org/id/BAA35953 EnsemblBacteria b1131 http://www.ensemblgenomes.org/id/b1131 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004018 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004018 GO_function GO:0070626 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070626 GO_process GO:0006163 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006163 GO_process GO:0006189 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006189 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0044208 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044208 GO_process GO:0051262 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051262 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.275.10 http://www.cathdb.info/version/latest/superfamily/1.10.275.10 GeneID 945695 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945695 HOGENOM HOG000252916 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000252916&db=HOGENOM6 InParanoid P0AB89 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AB89 IntAct P0AB89 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AB89* IntEnz 4.3.2.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.3.2.2 InterPro IPR000362 http://www.ebi.ac.uk/interpro/entry/IPR000362 InterPro IPR004769 http://www.ebi.ac.uk/interpro/entry/IPR004769 InterPro IPR008948 http://www.ebi.ac.uk/interpro/entry/IPR008948 InterPro IPR013539 http://www.ebi.ac.uk/interpro/entry/IPR013539 InterPro IPR020557 http://www.ebi.ac.uk/interpro/entry/IPR020557 InterPro IPR022761 http://www.ebi.ac.uk/interpro/entry/IPR022761 InterPro IPR024083 http://www.ebi.ac.uk/interpro/entry/IPR024083 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1117 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1117 KEGG_Gene eco:b1131 http://www.genome.jp/dbget-bin/www_bget?eco:b1131 KEGG_Orthology KO:K01756 http://www.genome.jp/dbget-bin/www_bget?KO:K01756 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00250 http://www.genome.jp/kegg-bin/show_pathway?ko00250 KEGG_Reaction rn:R01083 http://www.genome.jp/dbget-bin/www_bget?rn:R01083 KEGG_Reaction rn:R04559 http://www.genome.jp/dbget-bin/www_bget?rn:R04559 MINT MINT-1253735 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1253735 OMA TQVNPCD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TQVNPCD PANTHER PTHR11444 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11444 PDB 2PTQ http://www.ebi.ac.uk/pdbe-srv/view/entry/2PTQ PDB 2PTR http://www.ebi.ac.uk/pdbe-srv/view/entry/2PTR PDB 2PTS http://www.ebi.ac.uk/pdbe-srv/view/entry/2PTS PDBsum 2PTQ http://www.ebi.ac.uk/pdbsum/2PTQ PDBsum 2PTR http://www.ebi.ac.uk/pdbsum/2PTR PDBsum 2PTS http://www.ebi.ac.uk/pdbsum/2PTS PRINTS PR00149 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00149 PROSITE PS00163 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00163 PSORT swissprot:PUR8_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PUR8_ECOLI PSORT-B swissprot:PUR8_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PUR8_ECOLI PSORT2 swissprot:PUR8_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PUR8_ECOLI Pfam PF00206 http://pfam.xfam.org/family/PF00206 Pfam PF08328 http://pfam.xfam.org/family/PF08328 Phobius swissprot:PUR8_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PUR8_ECOLI PhylomeDB P0AB89 http://phylomedb.org/?seqid=P0AB89 ProteinModelPortal P0AB89 http://www.proteinmodelportal.org/query/uniprot/P0AB89 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1729205 http://www.ncbi.nlm.nih.gov/pubmed/1729205 PubMed 1729240 http://www.ncbi.nlm.nih.gov/pubmed/1729240 PubMed 17531264 http://www.ncbi.nlm.nih.gov/pubmed/17531264 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415649 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415649 RefSeq WP_000423742 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000423742 SMR P0AB89 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AB89 STRING 511145.b1131 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1131&targetmode=cogs STRING COG0015 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0015&targetmode=cogs SUPFAM SSF48557 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48557 TIGRFAMs TIGR00928 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00928 UniProtKB PUR8_ECOLI http://www.uniprot.org/uniprot/PUR8_ECOLI UniProtKB-AC P0AB89 http://www.uniprot.org/uniprot/P0AB89 charge swissprot:PUR8_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PUR8_ECOLI eggNOG COG0015 http://eggnogapi.embl.de/nog_data/html/tree/COG0015 eggNOG ENOG4107QTF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QTF epestfind swissprot:PUR8_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PUR8_ECOLI garnier swissprot:PUR8_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PUR8_ECOLI helixturnhelix swissprot:PUR8_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PUR8_ECOLI hmoment swissprot:PUR8_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PUR8_ECOLI iep swissprot:PUR8_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PUR8_ECOLI inforesidue swissprot:PUR8_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PUR8_ECOLI octanol swissprot:PUR8_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PUR8_ECOLI pepcoil swissprot:PUR8_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PUR8_ECOLI pepdigest swissprot:PUR8_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PUR8_ECOLI pepinfo swissprot:PUR8_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PUR8_ECOLI pepnet swissprot:PUR8_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PUR8_ECOLI pepstats swissprot:PUR8_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PUR8_ECOLI pepwheel swissprot:PUR8_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PUR8_ECOLI pepwindow swissprot:PUR8_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PUR8_ECOLI sigcleave swissprot:PUR8_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PUR8_ECOLI ## Database ID URL or Descriptions # EcoGene EG14474 ilvX # INDUCTION ILVX_ECOLI In stationary phase (PubMed 19121005) and in minimal glucose or glycerol medium (PubMed 19734316) (at protein level). {ECO 0000269|PubMed 19121005, ECO 0000269|PubMed 19734316}. # Organism ILVX_ECOLI Escherichia coli (strain K12) # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ILVX_ECOLI Uncharacterized protein IlvX # RefSeq YP_002791259 NC_000913.3 BLAST swissprot:ILVX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ILVX_ECOLI BioCyc EcoCyc:MONOMER0-2868 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2868 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2008.06495.x http://dx.doi.org/10.1111/j.1365-2958.2008.06495.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00872-09 http://dx.doi.org/10.1128/JB.00872-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14474 http://www.ecogene.org/geneInfo.php?eg_id=EG14474 EnsemblBacteria ACO60011 http://www.ensemblgenomes.org/id/ACO60011 EnsemblBacteria ACO60011 http://www.ensemblgenomes.org/id/ACO60011 EnsemblBacteria b4669 http://www.ensemblgenomes.org/id/b4669 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 7751639 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7751639 KEGG_Gene eco:b4669 http://www.genome.jp/dbget-bin/www_bget?eco:b4669 PSORT swissprot:ILVX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ILVX_ECOLI PSORT-B swissprot:ILVX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ILVX_ECOLI PSORT2 swissprot:ILVX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ILVX_ECOLI Phobius swissprot:ILVX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ILVX_ECOLI PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19121005 http://www.ncbi.nlm.nih.gov/pubmed/19121005 PubMed 19734316 http://www.ncbi.nlm.nih.gov/pubmed/19734316 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq YP_002791259 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_002791259 STRING 511145.b4669 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4669&targetmode=cogs UniProtKB ILVX_ECOLI http://www.uniprot.org/uniprot/ILVX_ECOLI UniProtKB-AC C1P619 http://www.uniprot.org/uniprot/C1P619 charge swissprot:ILVX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ILVX_ECOLI epestfind swissprot:ILVX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ILVX_ECOLI garnier swissprot:ILVX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ILVX_ECOLI helixturnhelix swissprot:ILVX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ILVX_ECOLI hmoment swissprot:ILVX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ILVX_ECOLI iep swissprot:ILVX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ILVX_ECOLI inforesidue swissprot:ILVX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ILVX_ECOLI octanol swissprot:ILVX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ILVX_ECOLI pepcoil swissprot:ILVX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ILVX_ECOLI pepdigest swissprot:ILVX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ILVX_ECOLI pepinfo swissprot:ILVX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ILVX_ECOLI pepnet swissprot:ILVX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ILVX_ECOLI pepstats swissprot:ILVX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ILVX_ECOLI pepwheel swissprot:ILVX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ILVX_ECOLI pepwindow swissprot:ILVX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ILVX_ECOLI sigcleave swissprot:ILVX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ILVX_ECOLI ## Database ID URL or Descriptions # AltName KBAY_ECOLI D-tagatose-bisphosphate aldolase class II # AltName KBAY_ECOLI Ketose 1,6-bisphosphate aldolase class II # AltName KBAY_ECOLI Tagatose-bisphosphate aldolase # BIOPHYSICOCHEMICAL PROPERTIES KBAY_ECOLI Kinetic parameters KM=0.26 mM for tagatose-1,6-bisphosphate {ECO 0000269|PubMed 10712619}; KM=1.3 mM for fructose-1,6-bisphosphate {ECO 0000269|PubMed 10712619}; Note=The catalytic efficiency measured with tagatose-1,6- bisphosphate as substrate is 340-fold higher than that with fructose-1,6-bisphosphate.; # BRENDA 4.1.2.40 2026 # BioGrid 4261155 23 # CATALYTIC ACTIVITY D-tagatose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. {ECO:0000269|PubMed 10712619}. # COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI 29105; Note=Binds 1 zinc ion per subunit.; # EcoGene EG12768 kbaY # FUNCTION KBAY_ECOLI Catalytic subunit of the tagatose-1,6-bisphosphate aldolase KbaYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6- bisphosphate (TBP). Requires KbaZ subunit for full activity and stability. {ECO 0000269|PubMed 10712619, ECO 0000269|PubMed 11976750}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0009025 tagatose-bisphosphate aldolase activity; IMP:EcoliWiki. # GO_process GO:0005975 carbohydrate metabolic process; IEA:UniProtKB-HAMAP. # GO_process GO:2001059 D-tagatose 6-phosphate catabolic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # Gene3D 3.20.20.70 -; 1. # HAMAP MF_01293 TagBP_aldolase_KbaY # IntAct P0AB74 7 # InterPro IPR000771 FBA_II # InterPro IPR011288 TagBP_ald_KbaY/GatY # InterPro IPR013785 Aldolase_TIM # InterPro IPR023788 TagBP_ald_KbaY # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00052 Galactose metabolism # MASS SPECTROMETRY Mass=31165.9; Mass_error=2.95; Method=Electrospray; Range=2-286; Evidence={ECO:0000269|PubMed 10712619}; # MISCELLANEOUS KBAY_ECOLI In contrast to E.coli strains C and EC3132, K-12 strains cannot grow on N-acetylgalactosamine and D-galactosamine, because they carry a deletion and thus lack active PTS systems specific for these compounds. Therefore, KbaYZ in K-12 strains is not involved in the degradation of these compounds. # Organism KBAY_ECOLI Escherichia coli (strain K12) # PATHWAY Carbohydrate metabolism; D-tagatose 6-phosphate degradation; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate step 2/2. # PATRIC 32121692 VBIEscCol129921_3232 # PDB 1GVF X-ray; 1.45 A; A/B=1-286 # PIR E65103 E65103 # PIRSF PIRSF001359 F_bP_aldolase_II # PROSITE PS00602 ALDOLASE_CLASS_II_1 # PROSITE PS00806 ALDOLASE_CLASS_II_2 # Pfam PF01116 F_bP_aldolase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName KBAY_ECOLI D-tagatose-1,6-bisphosphate aldolase subunit KbaY # RefSeq NP_417606 NC_000913.3 # RefSeq WP_000022766 NZ_LN832404.1 # SIMILARITY Belongs to the class II fructose-bisphosphate aldolase family. TagBP aldolase KbaY subfamily. {ECO 0000305}. # SUBUNIT KBAY_ECOLI Homotetramer. Forms a complex with KbaZ. {ECO 0000269|PubMed 10712619, ECO 0000269|PubMed 11940603}. # TIGRFAMs TIGR00167 cbbA # TIGRFAMs TIGR01858 tag_bisphos_ald # UniPathway UPA00704 UER00716 # eggNOG COG0191 LUCA # eggNOG ENOG4105D2N Bacteria BLAST swissprot:KBAY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:KBAY_ECOLI BioCyc ECOL316407:JW3106-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3106-MONOMER BioCyc EcoCyc:TAGAALDOL1-MONOMER http://biocyc.org/getid?id=EcoCyc:TAGAALDOL1-MONOMER BioCyc MetaCyc:TAGAALDOL1-MONOMER http://biocyc.org/getid?id=MetaCyc:TAGAALDOL1-MONOMER COG COG0191 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0191 DIP DIP-47961N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47961N DOI 10.1007/s00203-002-0406-6 http://dx.doi.org/10.1007/s00203-002-0406-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1432-1327.2000.01191.x http://dx.doi.org/10.1046/j.1432-1327.2000.01191.x DOI 10.1074/jbc.M202464200 http://dx.doi.org/10.1074/jbc.M202464200 DOI 10.1099/13500872-142-2-231 http://dx.doi.org/10.1099/13500872-142-2-231 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.1.2.40 http://www.genome.jp/dbget-bin/www_bget?EC:4.1.2.40 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 4.1.2.40 http://enzyme.expasy.org/EC/4.1.2.40 EchoBASE EB2621 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2621 EcoGene EG12768 http://www.ecogene.org/geneInfo.php?eg_id=EG12768 EnsemblBacteria AAC76171 http://www.ensemblgenomes.org/id/AAC76171 EnsemblBacteria AAC76171 http://www.ensemblgenomes.org/id/AAC76171 EnsemblBacteria BAE77183 http://www.ensemblgenomes.org/id/BAE77183 EnsemblBacteria BAE77183 http://www.ensemblgenomes.org/id/BAE77183 EnsemblBacteria BAE77183 http://www.ensemblgenomes.org/id/BAE77183 EnsemblBacteria b3137 http://www.ensemblgenomes.org/id/b3137 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0009025 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009025 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GO_process GO:2001059 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2001059 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 947644 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947644 HAMAP MF_01293 http://hamap.expasy.org/unirule/MF_01293 HOGENOM HOG000227793 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000227793&db=HOGENOM6 InParanoid P0AB74 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AB74 IntAct P0AB74 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AB74* IntEnz 4.1.2.40 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.2.40 InterPro IPR000771 http://www.ebi.ac.uk/interpro/entry/IPR000771 InterPro IPR011288 http://www.ebi.ac.uk/interpro/entry/IPR011288 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR023788 http://www.ebi.ac.uk/interpro/entry/IPR023788 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3106 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3106 KEGG_Gene eco:b3137 http://www.genome.jp/dbget-bin/www_bget?eco:b3137 KEGG_Orthology KO:K08302 http://www.genome.jp/dbget-bin/www_bget?KO:K08302 KEGG_Pathway ko00052 http://www.genome.jp/kegg-bin/show_pathway?ko00052 KEGG_Reaction rn:R01069 http://www.genome.jp/dbget-bin/www_bget?rn:R01069 MINT MINT-1279079 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1279079 OMA VNTREMF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VNTREMF PDB 1GVF http://www.ebi.ac.uk/pdbe-srv/view/entry/1GVF PDBsum 1GVF http://www.ebi.ac.uk/pdbsum/1GVF PROSITE PS00602 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00602 PROSITE PS00806 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00806 PSORT swissprot:KBAY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:KBAY_ECOLI PSORT-B swissprot:KBAY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:KBAY_ECOLI PSORT2 swissprot:KBAY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:KBAY_ECOLI Pfam PF01116 http://pfam.xfam.org/family/PF01116 Phobius swissprot:KBAY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:KBAY_ECOLI PhylomeDB P0AB74 http://phylomedb.org/?seqid=P0AB74 ProteinModelPortal P0AB74 http://www.proteinmodelportal.org/query/uniprot/P0AB74 PubMed 10712619 http://www.ncbi.nlm.nih.gov/pubmed/10712619 PubMed 11940603 http://www.ncbi.nlm.nih.gov/pubmed/11940603 PubMed 11976750 http://www.ncbi.nlm.nih.gov/pubmed/11976750 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8932697 http://www.ncbi.nlm.nih.gov/pubmed/8932697 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417606 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417606 RefSeq WP_000022766 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000022766 SMR P0AB74 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AB74 STRING 511145.b3137 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3137&targetmode=cogs STRING COG0191 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0191&targetmode=cogs TIGRFAMs TIGR00167 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00167 TIGRFAMs TIGR01858 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01858 UniProtKB KBAY_ECOLI http://www.uniprot.org/uniprot/KBAY_ECOLI UniProtKB-AC P0AB74 http://www.uniprot.org/uniprot/P0AB74 charge swissprot:KBAY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:KBAY_ECOLI eggNOG COG0191 http://eggnogapi.embl.de/nog_data/html/tree/COG0191 eggNOG ENOG4105D2N http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D2N epestfind swissprot:KBAY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:KBAY_ECOLI garnier swissprot:KBAY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:KBAY_ECOLI helixturnhelix swissprot:KBAY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:KBAY_ECOLI hmoment swissprot:KBAY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:KBAY_ECOLI iep swissprot:KBAY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:KBAY_ECOLI inforesidue swissprot:KBAY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:KBAY_ECOLI octanol swissprot:KBAY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:KBAY_ECOLI pepcoil swissprot:KBAY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:KBAY_ECOLI pepdigest swissprot:KBAY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:KBAY_ECOLI pepinfo swissprot:KBAY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:KBAY_ECOLI pepnet swissprot:KBAY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:KBAY_ECOLI pepstats swissprot:KBAY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:KBAY_ECOLI pepwheel swissprot:KBAY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:KBAY_ECOLI pepwindow swissprot:KBAY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:KBAY_ECOLI sigcleave swissprot:KBAY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:KBAY_ECOLI ## Database ID URL or Descriptions # AltName MREC_ECOLI Cell shape protein MreC # AltName MREC_ECOLI Rod shape-determining protein MreC # BioGrid 4261941 220 # DISRUPTION PHENOTYPE Reduction in growth rate and ultimately cell lysis. Growth arrest is associated with remarkable change in cell morphology from the normal rod-shape to enlarged, spherical cells. Many of the large spherical cells lyse at a later stage. {ECO:0000269|PubMed 15612918}. # EcoGene EG10609 mreC # FUNCTION MREC_ECOLI Involved in formation and maintenance of cell shape. Responsible for formation of rod shape. May also contribute to regulation of formation of penicillin-binding proteins. {ECO 0000269|PubMed 15612918, ECO 0000269|PubMed 2687239}. # GO_component GO:0005886 plasma membrane; IDA:UniProtKB. # GO_component GO:0005887 integral component of plasma membrane; ISM:EcoCyc. # GO_function GO:0043621 protein self-association; IPI:UniProtKB. # GO_process GO:0008360 regulation of cell shape; IMP:EcoCyc. # GO_process GO:0071963 establishment or maintenance of cell polarity regulating cell shape; IMP:UniProtKB. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0008150 biological_process # IntAct P16926 5 # InterPro IPR007221 MreC # KEGG_Brite ko03036 Chromosome # Organism MREC_ECOLI Escherichia coli (strain K12) # PATRIC 32121926 VBIEscCol129921_3347 # PIR JV0059 JV0059 # Pfam PF04085 MreC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MREC_ECOLI Cell shape-determining protein MreC # RefSeq NP_417716 NC_000913.3 # RefSeq WP_000802511 NZ_LN832404.1 # SIMILARITY Belongs to the MreC family. {ECO 0000305}. # SUBCELLULAR LOCATION MREC_ECOLI Cell inner membrane {ECO 0000269|PubMed 15612918}; Single-pass membrane protein {ECO 0000269|PubMed 15612918}. # SUBUNIT Self-associates. Interacts with MreB and MreD. {ECO:0000269|PubMed 15612918}. # TCDB 9.B.157.1 the cell shape-determining mrebcd (mrebcd) family # TIGRFAMs TIGR00219 mreC # eggNOG COG1792 LUCA # eggNOG ENOG4105N3I Bacteria BLAST swissprot:MREC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MREC_ECOLI BioCyc ECOL316407:JW3219-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3219-MONOMER BioCyc EcoCyc:EG10609-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10609-MONOMER COG COG1792 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1792 DIP DIP-10256N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10256N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2004.04367.x http://dx.doi.org/10.1111/j.1365-2958.2004.04367.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M22055 http://www.ebi.ac.uk/ena/data/view/M22055 EMBL M31792 http://www.ebi.ac.uk/ena/data/view/M31792 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB0604 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0604 EcoGene EG10609 http://www.ecogene.org/geneInfo.php?eg_id=EG10609 EnsemblBacteria AAC76282 http://www.ensemblgenomes.org/id/AAC76282 EnsemblBacteria AAC76282 http://www.ensemblgenomes.org/id/AAC76282 EnsemblBacteria BAE77292 http://www.ensemblgenomes.org/id/BAE77292 EnsemblBacteria BAE77292 http://www.ensemblgenomes.org/id/BAE77292 EnsemblBacteria BAE77292 http://www.ensemblgenomes.org/id/BAE77292 EnsemblBacteria b3250 http://www.ensemblgenomes.org/id/b3250 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0043621 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043621 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0071963 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071963 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 947655 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947655 HOGENOM HOG000266097 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000266097&db=HOGENOM6 InParanoid P16926 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P16926 IntAct P16926 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P16926* InterPro IPR007221 http://www.ebi.ac.uk/interpro/entry/IPR007221 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene ecj:JW3219 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3219 KEGG_Gene eco:b3250 http://www.genome.jp/dbget-bin/www_bget?eco:b3250 KEGG_Orthology KO:K03570 http://www.genome.jp/dbget-bin/www_bget?KO:K03570 MINT MINT-7012243 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-7012243 OMA VELMPYT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VELMPYT PSORT swissprot:MREC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MREC_ECOLI PSORT-B swissprot:MREC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MREC_ECOLI PSORT2 swissprot:MREC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MREC_ECOLI Pfam PF04085 http://pfam.xfam.org/family/PF04085 Phobius swissprot:MREC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MREC_ECOLI PhylomeDB P16926 http://phylomedb.org/?seqid=P16926 ProteinModelPortal P16926 http://www.proteinmodelportal.org/query/uniprot/P16926 PubMed 15612918 http://www.ncbi.nlm.nih.gov/pubmed/15612918 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2687239 http://www.ncbi.nlm.nih.gov/pubmed/2687239 PubMed 3049542 http://www.ncbi.nlm.nih.gov/pubmed/3049542 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417716 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417716 RefSeq WP_000802511 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000802511 SMR P16926 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P16926 STRING 511145.b3250 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3250&targetmode=cogs STRING COG1792 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1792&targetmode=cogs TCDB 9.B.157.1 http://www.tcdb.org/search/result.php?tc=9.B.157.1 TIGRFAMs TIGR00219 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00219 UniProtKB MREC_ECOLI http://www.uniprot.org/uniprot/MREC_ECOLI UniProtKB-AC P16926 http://www.uniprot.org/uniprot/P16926 charge swissprot:MREC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MREC_ECOLI eggNOG COG1792 http://eggnogapi.embl.de/nog_data/html/tree/COG1792 eggNOG ENOG4105N3I http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105N3I epestfind swissprot:MREC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MREC_ECOLI garnier swissprot:MREC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MREC_ECOLI helixturnhelix swissprot:MREC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MREC_ECOLI hmoment swissprot:MREC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MREC_ECOLI iep swissprot:MREC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MREC_ECOLI inforesidue swissprot:MREC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MREC_ECOLI octanol swissprot:MREC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MREC_ECOLI pepcoil swissprot:MREC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MREC_ECOLI pepdigest swissprot:MREC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MREC_ECOLI pepinfo swissprot:MREC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MREC_ECOLI pepnet swissprot:MREC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MREC_ECOLI pepstats swissprot:MREC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MREC_ECOLI pepwheel swissprot:MREC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MREC_ECOLI pepwindow swissprot:MREC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MREC_ECOLI sigcleave swissprot:MREC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MREC_ECOLI ## Database ID URL or Descriptions # BioGrid 4259455 125 # CDD cd06174 MFS # EcoGene EG13972 ydiM # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0022891 substrate-specific transmembrane transporter activity; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # InterPro IPR005829 Sugar_transporter_CS # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # Organism YDIM_ECOLI Escherichia coli (strain K12) # PATRIC 32118686 VBIEscCol129921_1761 # PIR B64927 B64927 # PROSITE PS00216 SUGAR_TRANSPORT_1 # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDIM_ECOLI Inner membrane transport protein YdiM # RefSeq NP_416205 NC_000913.3 # RefSeq WP_000795537 NZ_LN832404.1 # SIMILARITY Belongs to the major facilitator superfamily. {ECO 0000305}. # SUBCELLULAR LOCATION YDIM_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.15.12 the major facilitator superfamily (mfs) # eggNOG ENOG4105EMV Bacteria # eggNOG ENOG410XRAD LUCA BLAST swissprot:YDIM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDIM_ECOLI BioCyc ECOL316407:JW1680-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1680-MONOMER BioCyc EcoCyc:B1690-MONOMER http://biocyc.org/getid?id=EcoCyc:B1690-MONOMER DIP DIP-11754N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11754N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3729 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3729 EcoGene EG13972 http://www.ecogene.org/geneInfo.php?eg_id=EG13972 EnsemblBacteria AAC74760 http://www.ensemblgenomes.org/id/AAC74760 EnsemblBacteria AAC74760 http://www.ensemblgenomes.org/id/AAC74760 EnsemblBacteria BAE76503 http://www.ensemblgenomes.org/id/BAE76503 EnsemblBacteria BAE76503 http://www.ensemblgenomes.org/id/BAE76503 EnsemblBacteria BAE76503 http://www.ensemblgenomes.org/id/BAE76503 EnsemblBacteria b1690 http://www.ensemblgenomes.org/id/b1690 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0022891 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022891 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GeneID 946196 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946196 HOGENOM HOG000062520 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000062520&db=HOGENOM6 InParanoid P76197 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76197 IntAct P76197 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76197* InterPro IPR005829 http://www.ebi.ac.uk/interpro/entry/IPR005829 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Gene ecj:JW1680 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1680 KEGG_Gene eco:b1690 http://www.genome.jp/dbget-bin/www_bget?eco:b1690 OMA SIMWFDL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SIMWFDL PROSITE PS00216 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00216 PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:YDIM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDIM_ECOLI PSORT-B swissprot:YDIM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDIM_ECOLI PSORT2 swissprot:YDIM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDIM_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:YDIM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDIM_ECOLI PhylomeDB P76197 http://phylomedb.org/?seqid=P76197 ProteinModelPortal P76197 http://www.proteinmodelportal.org/query/uniprot/P76197 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416205 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416205 RefSeq WP_000795537 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000795537 STRING 511145.b1690 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1690&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.15.12 http://www.tcdb.org/search/result.php?tc=2.A.1.15.12 UniProtKB YDIM_ECOLI http://www.uniprot.org/uniprot/YDIM_ECOLI UniProtKB-AC P76197 http://www.uniprot.org/uniprot/P76197 charge swissprot:YDIM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDIM_ECOLI eggNOG ENOG4105EMV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EMV eggNOG ENOG410XRAD http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRAD epestfind swissprot:YDIM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDIM_ECOLI garnier swissprot:YDIM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDIM_ECOLI helixturnhelix swissprot:YDIM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDIM_ECOLI hmoment swissprot:YDIM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDIM_ECOLI iep swissprot:YDIM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDIM_ECOLI inforesidue swissprot:YDIM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDIM_ECOLI octanol swissprot:YDIM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDIM_ECOLI pepcoil swissprot:YDIM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDIM_ECOLI pepdigest swissprot:YDIM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDIM_ECOLI pepinfo swissprot:YDIM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDIM_ECOLI pepnet swissprot:YDIM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDIM_ECOLI pepstats swissprot:YDIM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDIM_ECOLI pepwheel swissprot:YDIM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDIM_ECOLI pepwindow swissprot:YDIM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDIM_ECOLI sigcleave swissprot:YDIM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDIM_ECOLI ## Database ID URL or Descriptions # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # Organism BICB_ECOLI Escherichia coli (strain K12) # PIR S24805 S24805 # RecName BICB_ECOLI Putative uncharacterized protein BicB BLAST swissprot:BICB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BICB_ECOLI DOI 10.1016/0378-1119(93)90625-D http://dx.doi.org/10.1016/0378-1119(93)90625-D EMBL U00008 http://www.ebi.ac.uk/ena/data/view/U00008 EMBL X63703 http://www.ebi.ac.uk/ena/data/view/X63703 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv PSORT swissprot:BICB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BICB_ECOLI PSORT-B swissprot:BICB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BICB_ECOLI PSORT2 swissprot:BICB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BICB_ECOLI Phobius swissprot:BICB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BICB_ECOLI ProteinModelPortal P28247 http://www.proteinmodelportal.org/query/uniprot/P28247 PubMed 8486276 http://www.ncbi.nlm.nih.gov/pubmed/8486276 UniProtKB BICB_ECOLI http://www.uniprot.org/uniprot/BICB_ECOLI UniProtKB-AC P28247 http://www.uniprot.org/uniprot/P28247 charge swissprot:BICB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BICB_ECOLI epestfind swissprot:BICB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BICB_ECOLI garnier swissprot:BICB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BICB_ECOLI helixturnhelix swissprot:BICB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BICB_ECOLI hmoment swissprot:BICB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BICB_ECOLI iep swissprot:BICB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BICB_ECOLI inforesidue swissprot:BICB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BICB_ECOLI octanol swissprot:BICB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BICB_ECOLI pepcoil swissprot:BICB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BICB_ECOLI pepdigest swissprot:BICB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BICB_ECOLI pepinfo swissprot:BICB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BICB_ECOLI pepnet swissprot:BICB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BICB_ECOLI pepstats swissprot:BICB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BICB_ECOLI pepwheel swissprot:BICB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BICB_ECOLI pepwindow swissprot:BICB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BICB_ECOLI sigcleave swissprot:BICB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BICB_ECOLI ## Database ID URL or Descriptions # BioGrid 4262848 10 # EcoGene EG14247 ymfI # Organism YMFI_ECOLI Escherichia coli (strain K12) # PIR D64859 D64859 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YMFI_ECOLI Uncharacterized protein YmfI # RefSeq NP_415661 NC_000913.3 BLAST swissprot:YMFI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YMFI_ECOLI BioCyc ECOL316407:JW5168-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5168-MONOMER BioCyc EcoCyc:G6587-MONOMER http://biocyc.org/getid?id=EcoCyc:G6587-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3996 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3996 EcoGene EG14247 http://www.ecogene.org/geneInfo.php?eg_id=EG14247 EnsemblBacteria AAC74227 http://www.ensemblgenomes.org/id/AAC74227 EnsemblBacteria AAC74227 http://www.ensemblgenomes.org/id/AAC74227 EnsemblBacteria BAE76378 http://www.ensemblgenomes.org/id/BAE76378 EnsemblBacteria BAE76378 http://www.ensemblgenomes.org/id/BAE76378 EnsemblBacteria BAE76378 http://www.ensemblgenomes.org/id/BAE76378 EnsemblBacteria b1143 http://www.ensemblgenomes.org/id/b1143 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945712 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945712 KEGG_Gene ecj:JW5168 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5168 KEGG_Gene eco:b1143 http://www.genome.jp/dbget-bin/www_bget?eco:b1143 PSORT swissprot:YMFI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YMFI_ECOLI PSORT-B swissprot:YMFI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YMFI_ECOLI PSORT2 swissprot:YMFI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YMFI_ECOLI Phobius swissprot:YMFI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YMFI_ECOLI ProteinModelPortal P75972 http://www.proteinmodelportal.org/query/uniprot/P75972 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415661 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415661 STRING 511145.b1143 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1143&targetmode=cogs UniProtKB YMFI_ECOLI http://www.uniprot.org/uniprot/YMFI_ECOLI UniProtKB-AC P75972 http://www.uniprot.org/uniprot/P75972 charge swissprot:YMFI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YMFI_ECOLI epestfind swissprot:YMFI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YMFI_ECOLI garnier swissprot:YMFI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YMFI_ECOLI helixturnhelix swissprot:YMFI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YMFI_ECOLI hmoment swissprot:YMFI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YMFI_ECOLI iep swissprot:YMFI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YMFI_ECOLI inforesidue swissprot:YMFI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YMFI_ECOLI octanol swissprot:YMFI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YMFI_ECOLI pepcoil swissprot:YMFI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YMFI_ECOLI pepdigest swissprot:YMFI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YMFI_ECOLI pepinfo swissprot:YMFI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YMFI_ECOLI pepnet swissprot:YMFI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YMFI_ECOLI pepstats swissprot:YMFI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YMFI_ECOLI pepwheel swissprot:YMFI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YMFI_ECOLI pepwindow swissprot:YMFI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YMFI_ECOLI sigcleave swissprot:YMFI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YMFI_ECOLI ## Database ID URL or Descriptions # BioGrid 4263113 3 # DOMAIN CORA_ECOLI The central ion permeation pathway is formed by the first transmembrane domain from each of the five subunits. Mg(2+) binding strengthens interactions between subunits and leads to the formation of a symmetrical homopentamer surrounding a closed ion permeation pathway. Co(2+) binding also induces a conformation change. Low Mg(2+) concentrations trigger both a conformation change within each subunit and a loosening of the interactions between subunits. This results in an open ion conduction pathway. In addition, this results in a less symmetrical shape of the whole complex. {ECO 0000250|UniProtKB Q9WZ31}. # EcoGene EG11463 corA # FUNCTION CORA_ECOLI Mediates influx of magnesium ions. Can also mediate cobalt and manganese uptake (PubMed 780341). Alternates between open and closed states. Activated by low cytoplasmic Mg(2+) levels. Inactive when cytoplasmic Mg(2+) levels are high (By similarity). {ECO 0000250|UniProtKB Q9WZ31, ECO 0000269|PubMed 780341}. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0015087 cobalt ion transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0015095 magnesium ion transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0015099 nickel cation transmembrane transporter activity; IDA:EcoCyc. # GO_process GO:0006824 cobalt ion transport; IDA:EcoCyc. # GO_process GO:0015693 magnesium ion transport; IDA:EcoCyc. # GO_process GO:0035444 nickel cation transmembrane transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # IntAct P0ABI4 4 # InterPro IPR002523 MgTranspt_CorA/ZnTranspt_ZntB # InterPro IPR004488 Mg/Co-transport_prot_CorA # KEGG_Brite ko02000 Transporters # Organism CORA_ECOLI Escherichia coli (strain K12) # PATRIC 32123133 VBIEscCol129921_3932 # PIR A65186 B47157 # Pfam PF01544 CorA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CORA_ECOLI Magnesium transport protein CorA # RefSeq NP_418260 NC_000913.3 # RefSeq WP_000947159 NZ_LN832404.1 # SIMILARITY Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family. {ECO 0000305}. # SUBCELLULAR LOCATION CORA_ECOLI Cell inner membrane {ECO 0000305|PubMed 780341}; Multi-pass membrane protein {ECO 0000250|UniProtKB Q9WZ31}. # SUBUNIT Homopentamer. In the absence of Mg(2+), interactions between subunits are weakened, and dimers, trimers and tetramers can be observed in vitro (By similarity). {ECO:0000250|UniProtKB Q9WZ31}. # TCDB 1.A.35.1 the cora metal ion transporter (mit) family # TIGRFAMs TIGR00383 corA # eggNOG COG0598 LUCA # eggNOG ENOG4107QUT Bacteria BLAST swissprot:CORA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CORA_ECOLI BioCyc ECOL316407:JW3789-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3789-MONOMER BioCyc EcoCyc:CORA-MONOMER http://biocyc.org/getid?id=EcoCyc:CORA-MONOMER BioCyc MetaCyc:CORA-MONOMER http://biocyc.org/getid?id=MetaCyc:CORA-MONOMER COG COG0598 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0598 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L02122 http://www.ebi.ac.uk/ena/data/view/L02122 EMBL L11042 http://www.ebi.ac.uk/ena/data/view/L11042 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1431 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1431 EcoGene EG11463 http://www.ecogene.org/geneInfo.php?eg_id=EG11463 EnsemblBacteria AAC76819 http://www.ensemblgenomes.org/id/AAC76819 EnsemblBacteria AAC76819 http://www.ensemblgenomes.org/id/AAC76819 EnsemblBacteria BAE77485 http://www.ensemblgenomes.org/id/BAE77485 EnsemblBacteria BAE77485 http://www.ensemblgenomes.org/id/BAE77485 EnsemblBacteria BAE77485 http://www.ensemblgenomes.org/id/BAE77485 EnsemblBacteria b3816 http://www.ensemblgenomes.org/id/b3816 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015087 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015087 GO_function GO:0015095 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015095 GO_function GO:0015099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015099 GO_process GO:0006824 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006824 GO_process GO:0015693 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015693 GO_process GO:0035444 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035444 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 948351 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948351 HOGENOM HOG000276873 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276873&db=HOGENOM6 InParanoid P0ABI4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABI4 IntAct P0ABI4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABI4* InterPro IPR002523 http://www.ebi.ac.uk/interpro/entry/IPR002523 InterPro IPR004488 http://www.ebi.ac.uk/interpro/entry/IPR004488 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3789 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3789 KEGG_Gene eco:b3816 http://www.genome.jp/dbget-bin/www_bget?eco:b3816 KEGG_Orthology KO:K03284 http://www.genome.jp/dbget-bin/www_bget?KO:K03284 OMA RRAVSFM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RRAVSFM PSORT swissprot:CORA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CORA_ECOLI PSORT-B swissprot:CORA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CORA_ECOLI PSORT2 swissprot:CORA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CORA_ECOLI Pfam PF01544 http://pfam.xfam.org/family/PF01544 Phobius swissprot:CORA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CORA_ECOLI PhylomeDB P0ABI4 http://phylomedb.org/?seqid=P0ABI4 ProteinModelPortal P0ABI4 http://www.proteinmodelportal.org/query/uniprot/P0ABI4 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 780341 http://www.ncbi.nlm.nih.gov/pubmed/780341 PubMed 8314774 http://www.ncbi.nlm.nih.gov/pubmed/8314774 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418260 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418260 RefSeq WP_000947159 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000947159 STRING 511145.b3816 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3816&targetmode=cogs STRING COG0598 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0598&targetmode=cogs TCDB 1.A.35.1 http://www.tcdb.org/search/result.php?tc=1.A.35.1 TIGRFAMs TIGR00383 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00383 UniProtKB CORA_ECOLI http://www.uniprot.org/uniprot/CORA_ECOLI UniProtKB-AC P0ABI4 http://www.uniprot.org/uniprot/P0ABI4 charge swissprot:CORA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CORA_ECOLI eggNOG COG0598 http://eggnogapi.embl.de/nog_data/html/tree/COG0598 eggNOG ENOG4107QUT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QUT epestfind swissprot:CORA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CORA_ECOLI garnier swissprot:CORA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CORA_ECOLI helixturnhelix swissprot:CORA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CORA_ECOLI hmoment swissprot:CORA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CORA_ECOLI iep swissprot:CORA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CORA_ECOLI inforesidue swissprot:CORA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CORA_ECOLI octanol swissprot:CORA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CORA_ECOLI pepcoil swissprot:CORA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CORA_ECOLI pepdigest swissprot:CORA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CORA_ECOLI pepinfo swissprot:CORA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CORA_ECOLI pepnet swissprot:CORA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CORA_ECOLI pepstats swissprot:CORA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CORA_ECOLI pepwheel swissprot:CORA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CORA_ECOLI pepwindow swissprot:CORA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CORA_ECOLI sigcleave swissprot:CORA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CORA_ECOLI ## Database ID URL or Descriptions # AltName USHA_ECOLI UDP-sugar diphosphatase # AltName USHA_ECOLI UDP-sugar pyrophosphatase # AltName USHA_ECOLI UDP-sugar pyrophosphatase # BRENDA 3.1.3 2026 # BioGrid 4259843 4 # CATALYTIC ACTIVITY USHA_ECOLI A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate. # CATALYTIC ACTIVITY USHA_ECOLI UDP-sugar + H(2)O = UMP + alpha-D-aldose 1- phosphate. # COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI 29105; Note=Binds 2 Zn(2+) ions per subunit.; # ENZYME REGULATION USHA_ECOLI The activity of this protein is inhibited by an intracellular protein inhibitor. # EcoGene EG11060 ushA # FUNCTION USHA_ECOLI Degradation of external UDP-glucose to uridine monophosphate and glucose-1-phosphate, which can then be used by the cell. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IMP:EcoCyc. # GO_function GO:0000166 nucleotide binding; IEA:UniProtKB-KW. # GO_function GO:0008253 5'-nucleotidase activity; IDA:EcoCyc. # GO_function GO:0008768 UDP-sugar diphosphatase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0009166 nucleotide catabolic process; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.60.21.10 -; 1. # Gene3D 3.90.780.10 -; 1. # IntAct P07024 10 # InterPro IPR004843 Calcineurin-like_PHP_ApaH # InterPro IPR006146 5'-Nucleotdase_CS # InterPro IPR006179 5_nucleotidase/apyrase # InterPro IPR008334 5'-Nucleotdase_C # InterPro IPR029052 Metallo-depent_PP-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00240 Pyrimidine metabolism # KEGG_Pathway ko00760 Nicotinate and nicotinamide metabolism # Organism USHA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11575 PTHR11575 # PATRIC 32116117 VBIEscCol129921_0500 # PDB 1HO5 X-ray; 2.10 A; A/B=26-550 # PDB 1HP1 X-ray; 1.70 A; A=26-541 # PDB 1HPU X-ray; 1.85 A; A/B/C/D=26-550 # PDB 1OI8 X-ray; 2.10 A; A/B=26-550 # PDB 1OID X-ray; 2.10 A; A/B=26-550 # PDB 1OIE X-ray; 2.33 A; A=26-550 # PDB 1USH X-ray; 1.73 A; A=1-550 # PDB 2USH X-ray; 2.22 A; A/B=1-550 # PDB 4WWL X-ray; 2.23 A; A=26-550 # PIR G64778 YXECUG # PRINTS PR01607 APYRASEFAMLY # PROSITE PS00785 5_NUCLEOTIDASE_1 # PROSITE PS00786 5_NUCLEOTIDASE_2 # Pfam PF00149 Metallophos # Pfam PF02872 5_nucleotid_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName USHA_ECOLI 5'-nucleotidase # RecName USHA_ECOLI Protein UshA # RecName USHA_ECOLI Protein UshA # RecName USHA_ECOLI UDP-sugar hydrolase # RefSeq NP_415013 NC_000913.3 # RefSeq WP_000771748 NZ_LN832404.1 # SIMILARITY Belongs to the 5'-nucleotidase family. {ECO 0000305}. # SUBCELLULAR LOCATION USHA_ECOLI Periplasm. Note=Exported from the cell, except a small proportion that is internally localized. # SUBUNIT USHA_ECOLI Monomer. {ECO 0000269|PubMed 11491293, ECO 0000269|PubMed 11491294}. # SUPFAM SSF55816 SSF55816 # SUPFAM SSF56300 SSF56300 # eggNOG COG0737 LUCA # eggNOG ENOG4105CGH Bacteria BLAST swissprot:USHA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:USHA_ECOLI BioCyc ECOL316407:JW0469-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0469-MONOMER BioCyc EcoCyc:USHA-MONOMER http://biocyc.org/getid?id=EcoCyc:USHA-MONOMER BioCyc MetaCyc:USHA-MONOMER http://biocyc.org/getid?id=MetaCyc:USHA-MONOMER COG COG0737 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0737 DIP DIP-11096N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11096N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.2001.4656 http://dx.doi.org/10.1006/jmbi.2001.4656 DOI 10.1006/jmbi.2001.4657 http://dx.doi.org/10.1006/jmbi.2001.4657 DOI 10.1038/8253 http://dx.doi.org/10.1038/8253 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/14.10.4325 http://dx.doi.org/10.1093/nar/14.10.4325 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.3.5 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.5 EC_number EC:3.6.1.45 http://www.genome.jp/dbget-bin/www_bget?EC:3.6.1.45 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D73370 http://www.ebi.ac.uk/ena/data/view/D73370 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL X03895 http://www.ebi.ac.uk/ena/data/view/X03895 ENZYME 3.1.3.5 http://enzyme.expasy.org/EC/3.1.3.5 ENZYME 3.6.1.45 http://enzyme.expasy.org/EC/3.6.1.45 EchoBASE EB1053 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1053 EcoGene EG11060 http://www.ecogene.org/geneInfo.php?eg_id=EG11060 EnsemblBacteria AAC73582 http://www.ensemblgenomes.org/id/AAC73582 EnsemblBacteria AAC73582 http://www.ensemblgenomes.org/id/AAC73582 EnsemblBacteria BAE76259 http://www.ensemblgenomes.org/id/BAE76259 EnsemblBacteria BAE76259 http://www.ensemblgenomes.org/id/BAE76259 EnsemblBacteria BAE76259 http://www.ensemblgenomes.org/id/BAE76259 EnsemblBacteria b0480 http://www.ensemblgenomes.org/id/b0480 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0000166 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000166 GO_function GO:0008253 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008253 GO_function GO:0008768 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008768 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0009166 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009166 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.60.21.10 http://www.cathdb.info/version/latest/superfamily/3.60.21.10 Gene3D 3.90.780.10 http://www.cathdb.info/version/latest/superfamily/3.90.780.10 GeneID 947331 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947331 HOGENOM HOG000247216 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000247216&db=HOGENOM6 InParanoid P07024 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P07024 IntAct P07024 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P07024* IntEnz 3.1.3.5 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.5 IntEnz 3.6.1.45 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.1.45 InterPro IPR004843 http://www.ebi.ac.uk/interpro/entry/IPR004843 InterPro IPR006146 http://www.ebi.ac.uk/interpro/entry/IPR006146 InterPro IPR006179 http://www.ebi.ac.uk/interpro/entry/IPR006179 InterPro IPR008334 http://www.ebi.ac.uk/interpro/entry/IPR008334 InterPro IPR029052 http://www.ebi.ac.uk/interpro/entry/IPR029052 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0469 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0469 KEGG_Gene eco:b0480 http://www.genome.jp/dbget-bin/www_bget?eco:b0480 KEGG_Orthology KO:K11751 http://www.genome.jp/dbget-bin/www_bget?KO:K11751 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Pathway ko00760 http://www.genome.jp/kegg-bin/show_pathway?ko00760 KEGG_Reaction rn:R00183 http://www.genome.jp/dbget-bin/www_bget?rn:R00183 KEGG_Reaction rn:R00511 http://www.genome.jp/dbget-bin/www_bget?rn:R00511 KEGG_Reaction rn:R00963 http://www.genome.jp/dbget-bin/www_bget?rn:R00963 KEGG_Reaction rn:R01126 http://www.genome.jp/dbget-bin/www_bget?rn:R01126 KEGG_Reaction rn:R01227 http://www.genome.jp/dbget-bin/www_bget?rn:R01227 KEGG_Reaction rn:R01569 http://www.genome.jp/dbget-bin/www_bget?rn:R01569 KEGG_Reaction rn:R01664 http://www.genome.jp/dbget-bin/www_bget?rn:R01664 KEGG_Reaction rn:R01968 http://www.genome.jp/dbget-bin/www_bget?rn:R01968 KEGG_Reaction rn:R02088 http://www.genome.jp/dbget-bin/www_bget?rn:R02088 KEGG_Reaction rn:R02323 http://www.genome.jp/dbget-bin/www_bget?rn:R02323 KEGG_Reaction rn:R02719 http://www.genome.jp/dbget-bin/www_bget?rn:R02719 KEGG_Reaction rn:R03346 http://www.genome.jp/dbget-bin/www_bget?rn:R03346 MINT MINT-1256646 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1256646 OMA TLNILHI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TLNILHI PANTHER PTHR11575 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11575 PDB 1HO5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1HO5 PDB 1HP1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1HP1 PDB 1HPU http://www.ebi.ac.uk/pdbe-srv/view/entry/1HPU PDB 1OI8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1OI8 PDB 1OID http://www.ebi.ac.uk/pdbe-srv/view/entry/1OID PDB 1OIE http://www.ebi.ac.uk/pdbe-srv/view/entry/1OIE PDB 1USH http://www.ebi.ac.uk/pdbe-srv/view/entry/1USH PDB 2USH http://www.ebi.ac.uk/pdbe-srv/view/entry/2USH PDB 4WWL http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWL PDBsum 1HO5 http://www.ebi.ac.uk/pdbsum/1HO5 PDBsum 1HP1 http://www.ebi.ac.uk/pdbsum/1HP1 PDBsum 1HPU http://www.ebi.ac.uk/pdbsum/1HPU PDBsum 1OI8 http://www.ebi.ac.uk/pdbsum/1OI8 PDBsum 1OID http://www.ebi.ac.uk/pdbsum/1OID PDBsum 1OIE http://www.ebi.ac.uk/pdbsum/1OIE PDBsum 1USH http://www.ebi.ac.uk/pdbsum/1USH PDBsum 2USH http://www.ebi.ac.uk/pdbsum/2USH PDBsum 4WWL http://www.ebi.ac.uk/pdbsum/4WWL PRINTS PR01607 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01607 PROSITE PS00785 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00785 PROSITE PS00786 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00786 PSORT swissprot:USHA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:USHA_ECOLI PSORT-B swissprot:USHA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:USHA_ECOLI PSORT2 swissprot:USHA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:USHA_ECOLI Pfam PF00149 http://pfam.xfam.org/family/PF00149 Pfam PF02872 http://pfam.xfam.org/family/PF02872 Phobius swissprot:USHA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:USHA_ECOLI PhylomeDB P07024 http://phylomedb.org/?seqid=P07024 ProteinModelPortal P07024 http://www.proteinmodelportal.org/query/uniprot/P07024 PubMed 10331872 http://www.ncbi.nlm.nih.gov/pubmed/10331872 PubMed 11491293 http://www.ncbi.nlm.nih.gov/pubmed/11491293 PubMed 11491294 http://www.ncbi.nlm.nih.gov/pubmed/11491294 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3012467 http://www.ncbi.nlm.nih.gov/pubmed/3012467 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_415013 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415013 RefSeq WP_000771748 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000771748 SMR P07024 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P07024 STRING 511145.b0480 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0480&targetmode=cogs STRING COG0737 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0737&targetmode=cogs SUPFAM SSF55816 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55816 SUPFAM SSF56300 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56300 UniProtKB USHA_ECOLI http://www.uniprot.org/uniprot/USHA_ECOLI UniProtKB-AC P07024 http://www.uniprot.org/uniprot/P07024 charge swissprot:USHA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:USHA_ECOLI eggNOG COG0737 http://eggnogapi.embl.de/nog_data/html/tree/COG0737 eggNOG ENOG4105CGH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CGH epestfind swissprot:USHA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:USHA_ECOLI garnier swissprot:USHA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:USHA_ECOLI helixturnhelix swissprot:USHA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:USHA_ECOLI hmoment swissprot:USHA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:USHA_ECOLI iep swissprot:USHA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:USHA_ECOLI inforesidue swissprot:USHA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:USHA_ECOLI octanol swissprot:USHA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:USHA_ECOLI pepcoil swissprot:USHA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:USHA_ECOLI pepdigest swissprot:USHA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:USHA_ECOLI pepinfo swissprot:USHA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:USHA_ECOLI pepnet swissprot:USHA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:USHA_ECOLI pepstats swissprot:USHA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:USHA_ECOLI pepwheel swissprot:USHA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:USHA_ECOLI pepwindow swissprot:USHA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:USHA_ECOLI sigcleave swissprot:USHA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:USHA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261326 7 # CDD cd01392 HTH_LacI # EcoGene EG10819 rbsR # FUNCTION RBSR_ECOLI Transcriptional repressor for the ribose rbsDACBK operon. RbsR binds to a region of perfect dyad symmetry spanning the rbs operon transcriptional start site. The affinity for the rbs operator is reduced by addition of ribose, consistent with ribose being the inducer of the operon. # GO_function GO:0000986 bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding; IDA:EcoCyc. # GO_function GO:0001216 bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IEP:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.260.40 -; 1. # INTERACTION RBSR_ECOLI Q46864 mqsA; NbExp=3; IntAct=EBI-1119646, EBI-1120353; # IntAct P0ACQ0 5 # InterPro IPR000843 HTH_LacI # InterPro IPR010982 Lambda_DNA-bd_dom # InterPro IPR028082 Peripla_BP_I # KEGG_Brite ko03000 Transcription factors # Organism RBSR_ECOLI Escherichia coli (strain K12) # PATRIC 32123005 VBIEscCol129921_3878 # PIR B65179 B65179 # PRINTS PR00036 HTHLACI # PROSITE PS00356 HTH_LACI_1 # PROSITE PS50932 HTH_LACI_2 # Pfam PF00356 LacI # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RBSR_ECOLI Ribose operon repressor # RefSeq NP_418209 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA62106.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Contains 1 HTH lacI-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00111}. # SMART SM00354 HTH_LACI # SUPFAM SSF47413 SSF47413 # SUPFAM SSF53822 SSF53822 # eggNOG COG1609 LUCA # eggNOG ENOG4105ETE Bacteria BLAST swissprot:RBSR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RBSR_ECOLI BioCyc ECOL316407:JW3732-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3732-MONOMER BioCyc EcoCyc:PD03867 http://biocyc.org/getid?id=EcoCyc:PD03867 COG COG1609 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1609 DOI 10.1002/pro.5560010701 http://dx.doi.org/10.1002/pro.5560010701 DOI 10.1002/pro.5560010702 http://dx.doi.org/10.1002/pro.5560010702 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D10466 http://www.ebi.ac.uk/ena/data/view/D10466 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M13169 http://www.ebi.ac.uk/ena/data/view/M13169 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0812 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0812 EcoGene EG10819 http://www.ecogene.org/geneInfo.php?eg_id=EG10819 EnsemblBacteria AAC76776 http://www.ensemblgenomes.org/id/AAC76776 EnsemblBacteria AAC76776 http://www.ensemblgenomes.org/id/AAC76776 EnsemblBacteria BAE77535 http://www.ensemblgenomes.org/id/BAE77535 EnsemblBacteria BAE77535 http://www.ensemblgenomes.org/id/BAE77535 EnsemblBacteria BAE77535 http://www.ensemblgenomes.org/id/BAE77535 EnsemblBacteria b3753 http://www.ensemblgenomes.org/id/b3753 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000986 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000986 GO_function GO:0001216 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001216 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.260.40 http://www.cathdb.info/version/latest/superfamily/1.10.260.40 GeneID 948266 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948266 HOGENOM HOG000220180 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220180&db=HOGENOM6 InParanoid P0ACQ0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACQ0 IntAct P0ACQ0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACQ0* InterPro IPR000843 http://www.ebi.ac.uk/interpro/entry/IPR000843 InterPro IPR010982 http://www.ebi.ac.uk/interpro/entry/IPR010982 InterPro IPR028082 http://www.ebi.ac.uk/interpro/entry/IPR028082 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW3732 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3732 KEGG_Gene eco:b3753 http://www.genome.jp/dbget-bin/www_bget?eco:b3753 KEGG_Orthology KO:K02529 http://www.genome.jp/dbget-bin/www_bget?KO:K02529 OMA ERCCYER http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ERCCYER PRINTS PR00036 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00036 PROSITE PS00356 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00356 PROSITE PS50932 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50932 PSORT swissprot:RBSR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RBSR_ECOLI PSORT-B swissprot:RBSR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RBSR_ECOLI PSORT2 swissprot:RBSR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RBSR_ECOLI Pfam PF00356 http://pfam.xfam.org/family/PF00356 Phobius swissprot:RBSR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RBSR_ECOLI PhylomeDB P0ACQ0 http://phylomedb.org/?seqid=P0ACQ0 ProteinModelPortal P0ACQ0 http://www.proteinmodelportal.org/query/uniprot/P0ACQ0 PubMed 1304369 http://www.ncbi.nlm.nih.gov/pubmed/1304369 PubMed 1304370 http://www.ncbi.nlm.nih.gov/pubmed/1304370 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418209 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418209 SMART SM00354 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00354 SMR P0ACQ0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACQ0 STRING 511145.b3753 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3753&targetmode=cogs STRING COG1609 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1609&targetmode=cogs SUPFAM SSF47413 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47413 SUPFAM SSF53822 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822 UniProtKB RBSR_ECOLI http://www.uniprot.org/uniprot/RBSR_ECOLI UniProtKB-AC P0ACQ0 http://www.uniprot.org/uniprot/P0ACQ0 charge swissprot:RBSR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RBSR_ECOLI eggNOG COG1609 http://eggnogapi.embl.de/nog_data/html/tree/COG1609 eggNOG ENOG4105ETE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ETE epestfind swissprot:RBSR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RBSR_ECOLI garnier swissprot:RBSR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RBSR_ECOLI helixturnhelix swissprot:RBSR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RBSR_ECOLI hmoment swissprot:RBSR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RBSR_ECOLI iep swissprot:RBSR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RBSR_ECOLI inforesidue swissprot:RBSR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RBSR_ECOLI octanol swissprot:RBSR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RBSR_ECOLI pepcoil swissprot:RBSR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RBSR_ECOLI pepdigest swissprot:RBSR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RBSR_ECOLI pepinfo swissprot:RBSR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RBSR_ECOLI pepnet swissprot:RBSR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RBSR_ECOLI pepstats swissprot:RBSR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RBSR_ECOLI pepwheel swissprot:RBSR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RBSR_ECOLI pepwindow swissprot:RBSR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RBSR_ECOLI sigcleave swissprot:RBSR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RBSR_ECOLI ## Database ID URL or Descriptions # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_process GO:0000746 conjugation; IEA:UniProtKB-KW. # GO_process GO:0045454 cell redox homeostasis; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0008150 biological_process # GOslim_process GO:0042592 homeostatic process # Gene3D 3.40.30.10 -; 2. # InterPro IPR012336 Thioredoxin-like_fold # InterPro IPR013766 Thioredoxin_domain # InterPro IPR014109 Thiol-disulphide_isomerase_rbB # Organism TRBB_ECOLI Escherichia coli (strain K12) # PIR E32238 BVECTB # PROSITE PS51352 THIOREDOXIN_2 # RecName TRBB_ECOLI Protein TrbB # RefSeq NP_061474 NC_002483.1 # RefSeq WP_000059850 NZ_CP014273.1 # SIMILARITY Contains 1 thioredoxin domain. {ECO:0000255|PROSITE- ProRule PRU00691}. # SUBCELLULAR LOCATION TRBB_ECOLI Periplasm. # SUPFAM SSF52833 SSF52833 # TIGRFAMs TIGR02738 TrbB BLAST swissprot:TRBB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRBB_ECOLI DIP DIP-28104N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-28104N EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL M20787 http://www.ebi.ac.uk/ena/data/view/M20787 EMBL U01159 http://www.ebi.ac.uk/ena/data/view/U01159 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_process GO:0000746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000746 GO_process GO:0045454 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045454 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 Gene3D 3.40.30.10 http://www.cathdb.info/version/latest/superfamily/3.40.30.10 GeneID 1263514 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263514 InterPro IPR012336 http://www.ebi.ac.uk/interpro/entry/IPR012336 InterPro IPR013766 http://www.ebi.ac.uk/interpro/entry/IPR013766 InterPro IPR014109 http://www.ebi.ac.uk/interpro/entry/IPR014109 OMA FMARVDT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FMARVDT PROSITE PS51352 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51352 PSORT swissprot:TRBB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRBB_ECOLI PSORT-B swissprot:TRBB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRBB_ECOLI PSORT2 swissprot:TRBB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRBB_ECOLI Phobius swissprot:TRBB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRBB_ECOLI ProteinModelPortal P18035 http://www.proteinmodelportal.org/query/uniprot/P18035 PubMed 2536655 http://www.ncbi.nlm.nih.gov/pubmed/2536655 PubMed 7915817 http://www.ncbi.nlm.nih.gov/pubmed/7915817 RefSeq NP_061474 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061474 RefSeq WP_000059850 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000059850 SUPFAM SSF52833 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52833 TIGRFAMs TIGR02738 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02738 UniProtKB TRBB_ECOLI http://www.uniprot.org/uniprot/TRBB_ECOLI UniProtKB-AC P18035 http://www.uniprot.org/uniprot/P18035 charge swissprot:TRBB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRBB_ECOLI epestfind swissprot:TRBB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRBB_ECOLI garnier swissprot:TRBB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRBB_ECOLI helixturnhelix swissprot:TRBB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRBB_ECOLI hmoment swissprot:TRBB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRBB_ECOLI iep swissprot:TRBB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRBB_ECOLI inforesidue swissprot:TRBB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRBB_ECOLI octanol swissprot:TRBB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRBB_ECOLI pepcoil swissprot:TRBB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRBB_ECOLI pepdigest swissprot:TRBB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRBB_ECOLI pepinfo swissprot:TRBB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRBB_ECOLI pepnet swissprot:TRBB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRBB_ECOLI pepstats swissprot:TRBB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRBB_ECOLI pepwheel swissprot:TRBB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRBB_ECOLI pepwindow swissprot:TRBB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRBB_ECOLI sigcleave swissprot:TRBB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRBB_ECOLI ## Database ID URL or Descriptions # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0000746 conjugation; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0008150 biological_process # Organism TRBH_ECOLI Escherichia coli (strain K12) # PIR JS0294 Q4ECTD # RecName TRBH_ECOLI Protein TrbH # RefSeq NP_061482 NC_002483.1 # RefSeq WP_010892542 NC_002483.1 # SUBCELLULAR LOCATION TRBH_ECOLI Cell inner membrane {ECO 0000305}; Single- pass membrane protein {ECO 0000305}. BLAST swissprot:TRBH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRBH_ECOLI DOI 10.1016/0378-1119(89)90179-0 http://dx.doi.org/10.1016/0378-1119(89)90179-0 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL M29254 http://www.ebi.ac.uk/ena/data/view/M29254 EMBL M54796 http://www.ebi.ac.uk/ena/data/view/M54796 EMBL U01159 http://www.ebi.ac.uk/ena/data/view/U01159 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0000746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000746 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 1263576 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263576 OMA CLLMWIC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CLLMWIC PSORT swissprot:TRBH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRBH_ECOLI PSORT-B swissprot:TRBH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRBH_ECOLI PSORT2 swissprot:TRBH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRBH_ECOLI Phobius swissprot:TRBH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRBH_ECOLI ProteinModelPortal P19381 http://www.proteinmodelportal.org/query/uniprot/P19381 PubMed 2163400 http://www.ncbi.nlm.nih.gov/pubmed/2163400 PubMed 2680768 http://www.ncbi.nlm.nih.gov/pubmed/2680768 PubMed 7915817 http://www.ncbi.nlm.nih.gov/pubmed/7915817 RefSeq NP_061482 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061482 RefSeq WP_010892542 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_010892542 UniProtKB TRBH_ECOLI http://www.uniprot.org/uniprot/TRBH_ECOLI UniProtKB-AC P19381 http://www.uniprot.org/uniprot/P19381 charge swissprot:TRBH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRBH_ECOLI epestfind swissprot:TRBH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRBH_ECOLI garnier swissprot:TRBH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRBH_ECOLI helixturnhelix swissprot:TRBH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRBH_ECOLI hmoment swissprot:TRBH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRBH_ECOLI iep swissprot:TRBH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRBH_ECOLI inforesidue swissprot:TRBH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRBH_ECOLI octanol swissprot:TRBH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRBH_ECOLI pepcoil swissprot:TRBH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRBH_ECOLI pepdigest swissprot:TRBH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRBH_ECOLI pepinfo swissprot:TRBH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRBH_ECOLI pepnet swissprot:TRBH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRBH_ECOLI pepstats swissprot:TRBH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRBH_ECOLI pepwheel swissprot:TRBH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRBH_ECOLI pepwindow swissprot:TRBH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRBH_ECOLI sigcleave swissprot:TRBH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRBH_ECOLI ## Database ID URL or Descriptions # BioGrid 4262628 31 # EcoGene EG10385 glnG # FUNCTION NTRC_ECOLI Member of the two-component regulatory system NtrB/NtrC involved in the activation of nitrogen assimilatory genes such as GlnA. NtrC is phosphorylated by NtrB and interacts with sigma-54. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000156 phosphorelay response regulator activity; IEA:InterPro. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0043565 sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006808 regulation of nitrogen utilization; IEA:InterPro. # GO_process GO:0009399 nitrogen fixation; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0071941 nitrogen cycle metabolic process # Gene3D 1.10.10.60 -; 1. # Gene3D 3.40.50.300 -; 1. # INTERACTION NTRC_ECOLI P0ACZ4 evgA; NbExp=3; IntAct=EBI-1113197, EBI-548694; P0AFB5 glnL; NbExp=3; IntAct=EBI-1113197, EBI-701156; # IntAct P0AFB8 6 # InterPro IPR001789 Sig_transdc_resp-reg_receiver # InterPro IPR002078 Sigma_54_int # InterPro IPR002197 HTH_Fis # InterPro IPR003593 AAA+_ATPase # InterPro IPR009057 Homeodomain-like # InterPro IPR010114 Sig_transdc_resp-reg_NtrC # InterPro IPR011006 CheY-like_superfamily # InterPro IPR025662 Sigma_54_int_dom_ATP-bd_1 # InterPro IPR025943 Sigma_54_int_dom_ATP-bd_2 # InterPro IPR025944 Sigma_54_int_dom_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02022 M00497 GlnL-GlnG (nitrogen regulation) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # Organism NTRC_ECOLI Escherichia coli (strain K12) # PATRIC 32123239 VBIEscCol129921_3980 # PIR B30377 RGECGG # PRINTS PR01590 HTHFIS # PROSITE PS00675 SIGMA54_INTERACT_1 # PROSITE PS00676 SIGMA54_INTERACT_2 # PROSITE PS00688 SIGMA54_INTERACT_3 # PROSITE PS50045 SIGMA54_INTERACT_4 # PROSITE PS50110 RESPONSE_REGULATORY # Pfam PF00072 Response_reg # Pfam PF00158 Sigma54_activat # Pfam PF02954 HTH_8 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NTRC_ECOLI Nitrogen regulation protein NR(I) # RefSeq NP_418304 NC_000913.3 # RefSeq WP_001188777 NZ_LN832404.1 # SIMILARITY Contains 1 response regulatory domain. {ECO:0000255|PROSITE-ProRule PRU00169}. # SIMILARITY Contains 1 sigma-54 factor interaction domain. {ECO:0000255|PROSITE-ProRule PRU00193}. # SMART SM00382 AAA # SMART SM00448 REC # SUPFAM SSF46689 SSF46689 # SUPFAM SSF52172 SSF52172 # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR01818 ntrC # eggNOG COG2204 LUCA # eggNOG ENOG4105C1W Bacteria BLAST swissprot:NTRC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NTRC_ECOLI BioCyc ECOL316407:JW3839-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3839-MONOMER BioCyc EcoCyc:PROTEIN-NRI http://biocyc.org/getid?id=EcoCyc:PROTEIN-NRI COG COG2204 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2204 DIP DIP-9781N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9781N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/15.6.2757 http://dx.doi.org/10.1093/nar/15.6.2757 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D16509 http://www.ebi.ac.uk/ena/data/view/D16509 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X05173 http://www.ebi.ac.uk/ena/data/view/X05173 EchoBASE EB0380 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0380 EcoGene EG10385 http://www.ecogene.org/geneInfo.php?eg_id=EG10385 EnsemblBacteria AAC76865 http://www.ensemblgenomes.org/id/AAC76865 EnsemblBacteria AAC76865 http://www.ensemblgenomes.org/id/AAC76865 EnsemblBacteria BAE77441 http://www.ensemblgenomes.org/id/BAE77441 EnsemblBacteria BAE77441 http://www.ensemblgenomes.org/id/BAE77441 EnsemblBacteria BAE77441 http://www.ensemblgenomes.org/id/BAE77441 EnsemblBacteria b3868 http://www.ensemblgenomes.org/id/b3868 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000156 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000156 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0006808 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006808 GO_process GO:0009399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009399 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0071941 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071941 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948361 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948361 HOGENOM HOG000058489 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000058489&db=HOGENOM6 InParanoid P0AFB8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFB8 IntAct P0AFB8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFB8* InterPro IPR001789 http://www.ebi.ac.uk/interpro/entry/IPR001789 InterPro IPR002078 http://www.ebi.ac.uk/interpro/entry/IPR002078 InterPro IPR002197 http://www.ebi.ac.uk/interpro/entry/IPR002197 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR010114 http://www.ebi.ac.uk/interpro/entry/IPR010114 InterPro IPR011006 http://www.ebi.ac.uk/interpro/entry/IPR011006 InterPro IPR025662 http://www.ebi.ac.uk/interpro/entry/IPR025662 InterPro IPR025943 http://www.ebi.ac.uk/interpro/entry/IPR025943 InterPro IPR025944 http://www.ebi.ac.uk/interpro/entry/IPR025944 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW3839 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3839 KEGG_Gene eco:b3868 http://www.genome.jp/dbget-bin/www_bget?eco:b3868 KEGG_Orthology KO:K07712 http://www.genome.jp/dbget-bin/www_bget?KO:K07712 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA GHSPVQV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GHSPVQV PRINTS PR01590 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01590 PROSITE PS00675 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00675 PROSITE PS00676 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00676 PROSITE PS00688 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00688 PROSITE PS50045 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50045 PROSITE PS50110 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50110 PSORT swissprot:NTRC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NTRC_ECOLI PSORT-B swissprot:NTRC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NTRC_ECOLI PSORT2 swissprot:NTRC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NTRC_ECOLI Pfam PF00072 http://pfam.xfam.org/family/PF00072 Pfam PF00158 http://pfam.xfam.org/family/PF00158 Pfam PF02954 http://pfam.xfam.org/family/PF02954 Phobius swissprot:NTRC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NTRC_ECOLI PhylomeDB P0AFB8 http://phylomedb.org/?seqid=P0AFB8 ProteinModelPortal P0AFB8 http://www.proteinmodelportal.org/query/uniprot/P0AFB8 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2882477 http://www.ncbi.nlm.nih.gov/pubmed/2882477 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418304 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418304 RefSeq WP_001188777 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001188777 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMART SM00448 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00448 SMR P0AFB8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFB8 STRING 511145.b3868 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3868&targetmode=cogs STRING COG2204 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2204&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF52172 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52172 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR01818 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01818 UniProtKB NTRC_ECOLI http://www.uniprot.org/uniprot/NTRC_ECOLI UniProtKB-AC P0AFB8 http://www.uniprot.org/uniprot/P0AFB8 charge swissprot:NTRC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NTRC_ECOLI eggNOG COG2204 http://eggnogapi.embl.de/nog_data/html/tree/COG2204 eggNOG ENOG4105C1W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C1W epestfind swissprot:NTRC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NTRC_ECOLI garnier swissprot:NTRC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NTRC_ECOLI helixturnhelix swissprot:NTRC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NTRC_ECOLI hmoment swissprot:NTRC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NTRC_ECOLI iep swissprot:NTRC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NTRC_ECOLI inforesidue swissprot:NTRC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NTRC_ECOLI octanol swissprot:NTRC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NTRC_ECOLI pepcoil swissprot:NTRC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NTRC_ECOLI pepdigest swissprot:NTRC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NTRC_ECOLI pepinfo swissprot:NTRC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NTRC_ECOLI pepnet swissprot:NTRC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NTRC_ECOLI pepstats swissprot:NTRC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NTRC_ECOLI pepwheel swissprot:NTRC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NTRC_ECOLI pepwindow swissprot:NTRC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NTRC_ECOLI sigcleave swissprot:NTRC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NTRC_ECOLI ## Database ID URL or Descriptions # BioGrid 4259663 241 # CDD cd06174 MFS # EcoGene EG12571 yjiJ # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR010645 MFS_4 # InterPro IPR020846 MFS_dom # Organism YJIJ_ECOLI Escherichia coli (strain K12) # PATRIC 32124268 VBIEscCol129921_4477 # PIR S56557 S56557 # Pfam PF06779 MFS_4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJIJ_ECOLI Uncharacterized protein YjiJ # RefSeq NP_418752 NC_000913.3 # RefSeq WP_001141220 NZ_LN832404.1 # SUBCELLULAR LOCATION YJIJ_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # SUPFAM SSF103473 SSF103473 # eggNOG ENOG4105CBP Bacteria # eggNOG ENOG410XNVC LUCA BLAST swissprot:YJIJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJIJ_ECOLI BioCyc ECOL316407:JW4295-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4295-MONOMER BioCyc EcoCyc:G7929-MONOMER http://biocyc.org/getid?id=EcoCyc:G7929-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2459 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2459 EcoGene EG12571 http://www.ecogene.org/geneInfo.php?eg_id=EG12571 EnsemblBacteria AAC77288 http://www.ensemblgenomes.org/id/AAC77288 EnsemblBacteria AAC77288 http://www.ensemblgenomes.org/id/AAC77288 EnsemblBacteria BAE78325 http://www.ensemblgenomes.org/id/BAE78325 EnsemblBacteria BAE78325 http://www.ensemblgenomes.org/id/BAE78325 EnsemblBacteria BAE78325 http://www.ensemblgenomes.org/id/BAE78325 EnsemblBacteria b4332 http://www.ensemblgenomes.org/id/b4332 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 948859 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948859 HOGENOM HOG000259245 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000259245&db=HOGENOM6 InParanoid P39381 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39381 InterPro IPR010645 http://www.ebi.ac.uk/interpro/entry/IPR010645 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Gene ecj:JW4295 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4295 KEGG_Gene eco:b4332 http://www.genome.jp/dbget-bin/www_bget?eco:b4332 OMA WAHGRER http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WAHGRER PSORT swissprot:YJIJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJIJ_ECOLI PSORT-B swissprot:YJIJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJIJ_ECOLI PSORT2 swissprot:YJIJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJIJ_ECOLI Pfam PF06779 http://pfam.xfam.org/family/PF06779 Phobius swissprot:YJIJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJIJ_ECOLI PhylomeDB P39381 http://phylomedb.org/?seqid=P39381 ProteinModelPortal P39381 http://www.proteinmodelportal.org/query/uniprot/P39381 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418752 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418752 RefSeq WP_001141220 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001141220 STRING 511145.b4332 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4332&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 UniProtKB YJIJ_ECOLI http://www.uniprot.org/uniprot/YJIJ_ECOLI UniProtKB-AC P39381 http://www.uniprot.org/uniprot/P39381 charge swissprot:YJIJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJIJ_ECOLI eggNOG ENOG4105CBP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CBP eggNOG ENOG410XNVC http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNVC epestfind swissprot:YJIJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJIJ_ECOLI garnier swissprot:YJIJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJIJ_ECOLI helixturnhelix swissprot:YJIJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJIJ_ECOLI hmoment swissprot:YJIJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJIJ_ECOLI iep swissprot:YJIJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJIJ_ECOLI inforesidue swissprot:YJIJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJIJ_ECOLI octanol swissprot:YJIJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJIJ_ECOLI pepcoil swissprot:YJIJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJIJ_ECOLI pepdigest swissprot:YJIJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJIJ_ECOLI pepinfo swissprot:YJIJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJIJ_ECOLI pepnet swissprot:YJIJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJIJ_ECOLI pepstats swissprot:YJIJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJIJ_ECOLI pepwheel swissprot:YJIJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJIJ_ECOLI pepwindow swissprot:YJIJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJIJ_ECOLI sigcleave swissprot:YJIJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJIJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4262131 133 # EcoGene EG11142 yfaA # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # IntAct P17994 6 # InterPro IPR018671 DUF2138 # Organism YFAA_ECOLI Escherichia coli (strain K12) # PATRIC 32119819 VBIEscCol129921_2319 # PIR D64993 D64993 # Pfam PF09909 DUF2138 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFAA_ECOLI Uncharacterized protein YfaA # RefSeq NP_416733 NC_000913.3 # RefSeq WP_000012305 NZ_LN832404.1 # eggNOG COG4685 LUCA # eggNOG ENOG4107FKF Bacteria BLAST swissprot:YFAA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFAA_ECOLI BioCyc ECOL316407:JW2224-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2224-MONOMER BioCyc EcoCyc:EG11142-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11142-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1365-2958.1987.tb01932.x http://dx.doi.org/10.1111/j.1365-2958.1987.tb01932.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL Y00544 http://www.ebi.ac.uk/ena/data/view/Y00544 EchoBASE EB1132 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1132 EcoGene EG11142 http://www.ecogene.org/geneInfo.php?eg_id=EG11142 EnsemblBacteria AAC75290 http://www.ensemblgenomes.org/id/AAC75290 EnsemblBacteria AAC75290 http://www.ensemblgenomes.org/id/AAC75290 EnsemblBacteria BAA16047 http://www.ensemblgenomes.org/id/BAA16047 EnsemblBacteria BAA16047 http://www.ensemblgenomes.org/id/BAA16047 EnsemblBacteria BAA16047 http://www.ensemblgenomes.org/id/BAA16047 EnsemblBacteria b2230 http://www.ensemblgenomes.org/id/b2230 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GeneID 946618 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946618 HOGENOM HOG000122367 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122367&db=HOGENOM6 InParanoid P17994 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P17994 IntAct P17994 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P17994* InterPro IPR018671 http://www.ebi.ac.uk/interpro/entry/IPR018671 KEGG_Gene ecj:JW2224 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2224 KEGG_Gene eco:b2230 http://www.genome.jp/dbget-bin/www_bget?eco:b2230 OMA LRRIIYE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LRRIIYE PSORT swissprot:YFAA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFAA_ECOLI PSORT-B swissprot:YFAA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFAA_ECOLI PSORT2 swissprot:YFAA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFAA_ECOLI Pfam PF09909 http://pfam.xfam.org/family/PF09909 Phobius swissprot:YFAA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFAA_ECOLI ProteinModelPortal P17994 http://www.proteinmodelportal.org/query/uniprot/P17994 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2834621 http://www.ncbi.nlm.nih.gov/pubmed/2834621 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416733 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416733 RefSeq WP_000012305 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000012305 STRING 511145.b2230 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2230&targetmode=cogs UniProtKB YFAA_ECOLI http://www.uniprot.org/uniprot/YFAA_ECOLI UniProtKB-AC P17994 http://www.uniprot.org/uniprot/P17994 charge swissprot:YFAA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFAA_ECOLI eggNOG COG4685 http://eggnogapi.embl.de/nog_data/html/tree/COG4685 eggNOG ENOG4107FKF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107FKF epestfind swissprot:YFAA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFAA_ECOLI garnier swissprot:YFAA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFAA_ECOLI helixturnhelix swissprot:YFAA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFAA_ECOLI hmoment swissprot:YFAA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFAA_ECOLI iep swissprot:YFAA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFAA_ECOLI inforesidue swissprot:YFAA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFAA_ECOLI octanol swissprot:YFAA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFAA_ECOLI pepcoil swissprot:YFAA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFAA_ECOLI pepdigest swissprot:YFAA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFAA_ECOLI pepinfo swissprot:YFAA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFAA_ECOLI pepnet swissprot:YFAA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFAA_ECOLI pepstats swissprot:YFAA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFAA_ECOLI pepwheel swissprot:YFAA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFAA_ECOLI pepwindow swissprot:YFAA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFAA_ECOLI sigcleave swissprot:YFAA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFAA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259685 258 # EcoGene EG11361 asmA # FUNCTION ASMA_ECOLI Involved in the inhibition of assembly of mutant ompF proteins. In general, could be involved in the assembly of outer membrane proteins. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_process GO:0090313 regulation of protein targeting to membrane; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0008150 biological_process # IntAct P28249 9 # InterPro IPR007844 AsmA # Organism ASMA_ECOLI Escherichia coli (strain K12) # PATRIC 32119461 VBIEscCol129921_2141 # PIR G64972 G64972 # Pfam PF05170 AsmA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ASMA_ECOLI Protein AsmA # RefSeq NP_416568 NC_000913.3 # RefSeq WP_001252331 NZ_LN832404.1 # SUBCELLULAR LOCATION ASMA_ECOLI Periplasm {ECO 0000305}. # TCDB 9.B.22.2 the leukotoxin secretion morphogenesis protein c (morc) family # eggNOG COG2982 LUCA # eggNOG ENOG4108GAE Bacteria BLAST swissprot:ASMA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ASMA_ECOLI BioCyc ECOL316407:JW2049-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2049-MONOMER BioCyc EcoCyc:EG11361-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11361-MONOMER COG COG2982 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2982 DIP DIP-9175N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9175N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1111/j.1365-2958.1995.tb02439.x http://dx.doi.org/10.1111/j.1365-2958.1995.tb02439.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M90069 http://www.ebi.ac.uk/ena/data/view/M90069 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U11035 http://www.ebi.ac.uk/ena/data/view/U11035 EchoBASE EB1336 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1336 EcoGene EG11361 http://www.ecogene.org/geneInfo.php?eg_id=EG11361 EnsemblBacteria AAC75125 http://www.ensemblgenomes.org/id/AAC75125 EnsemblBacteria AAC75125 http://www.ensemblgenomes.org/id/AAC75125 EnsemblBacteria BAA15917 http://www.ensemblgenomes.org/id/BAA15917 EnsemblBacteria BAA15917 http://www.ensemblgenomes.org/id/BAA15917 EnsemblBacteria BAA15917 http://www.ensemblgenomes.org/id/BAA15917 EnsemblBacteria b2064 http://www.ensemblgenomes.org/id/b2064 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_process GO:0090313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090313 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 946582 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946582 HOGENOM HOG000121998 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000121998&db=HOGENOM6 InParanoid P28249 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P28249 IntAct P28249 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P28249* InterPro IPR007844 http://www.ebi.ac.uk/interpro/entry/IPR007844 KEGG_Gene ecj:JW2049 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2049 KEGG_Gene eco:b2064 http://www.genome.jp/dbget-bin/www_bget?eco:b2064 KEGG_Orthology KO:K07289 http://www.genome.jp/dbget-bin/www_bget?KO:K07289 OMA DIRLQME http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DIRLQME PSORT swissprot:ASMA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ASMA_ECOLI PSORT-B swissprot:ASMA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ASMA_ECOLI PSORT2 swissprot:ASMA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ASMA_ECOLI Pfam PF05170 http://pfam.xfam.org/family/PF05170 Phobius swissprot:ASMA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ASMA_ECOLI ProteinModelPortal P28249 http://www.proteinmodelportal.org/query/uniprot/P28249 PubMed 1324907 http://www.ncbi.nlm.nih.gov/pubmed/1324907 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7476172 http://www.ncbi.nlm.nih.gov/pubmed/7476172 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416568 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416568 RefSeq WP_001252331 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001252331 STRING 511145.b2064 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2064&targetmode=cogs STRING COG2982 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2982&targetmode=cogs TCDB 9.B.22.2 http://www.tcdb.org/search/result.php?tc=9.B.22.2 UniProtKB ASMA_ECOLI http://www.uniprot.org/uniprot/ASMA_ECOLI UniProtKB-AC P28249 http://www.uniprot.org/uniprot/P28249 charge swissprot:ASMA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ASMA_ECOLI eggNOG COG2982 http://eggnogapi.embl.de/nog_data/html/tree/COG2982 eggNOG ENOG4108GAE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108GAE epestfind swissprot:ASMA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ASMA_ECOLI garnier swissprot:ASMA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ASMA_ECOLI helixturnhelix swissprot:ASMA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ASMA_ECOLI hmoment swissprot:ASMA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ASMA_ECOLI iep swissprot:ASMA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ASMA_ECOLI inforesidue swissprot:ASMA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ASMA_ECOLI octanol swissprot:ASMA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ASMA_ECOLI pepcoil swissprot:ASMA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ASMA_ECOLI pepdigest swissprot:ASMA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ASMA_ECOLI pepinfo swissprot:ASMA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ASMA_ECOLI pepnet swissprot:ASMA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ASMA_ECOLI pepstats swissprot:ASMA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ASMA_ECOLI pepwheel swissprot:ASMA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ASMA_ECOLI pepwindow swissprot:ASMA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ASMA_ECOLI sigcleave swissprot:ASMA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ASMA_ECOLI ## Database ID URL or Descriptions # AltName YHHI_ECOLI ORF-H # BioGrid 4263110 116 # EcoGene EG11525 yhhI # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # IntAct P28912 7 # InterPro IPR002559 Transposase_11 # InterPro IPR032806 YbfD_N # Organism YHHI_ECOLI Escherichia coli (strain K12) # PATRIC 32122412 VBIEscCol129921_3583 # PIR S47703 S47703 # Pfam PF01609 DDE_Tnp_1 # Pfam PF13808 DDE_Tnp_1_assoc # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHHI_ECOLI H repeat-associated protein YhhI # RefSeq NP_417941 NC_000913.3 # RefSeq WP_000420980 NZ_LN832404.1 # SIMILARITY Belongs to the transposase 11 family. {ECO 0000305}. # eggNOG COG5433 LUCA # eggNOG ENOG410600T Bacteria BLAST swissprot:YHHI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHHI_ECOLI BioCyc ECOL316407:JW3451-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3451-MONOMER BioCyc EcoCyc:EG11525-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11525-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L02370 http://www.ebi.ac.uk/ena/data/view/L02370 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U15126 http://www.ebi.ac.uk/ena/data/view/U15126 EchoBASE EB1487 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1487 EcoGene EG11525 http://www.ecogene.org/geneInfo.php?eg_id=EG11525 EnsemblBacteria AAC76509 http://www.ensemblgenomes.org/id/AAC76509 EnsemblBacteria AAC76509 http://www.ensemblgenomes.org/id/AAC76509 EnsemblBacteria BAE77809 http://www.ensemblgenomes.org/id/BAE77809 EnsemblBacteria BAE77809 http://www.ensemblgenomes.org/id/BAE77809 EnsemblBacteria BAE77809 http://www.ensemblgenomes.org/id/BAE77809 EnsemblBacteria b3484 http://www.ensemblgenomes.org/id/b3484 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GeneID 947992 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947992 HOGENOM HOG000042098 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000042098&db=HOGENOM6 InParanoid P28912 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P28912 IntAct P28912 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P28912* InterPro IPR002559 http://www.ebi.ac.uk/interpro/entry/IPR002559 InterPro IPR032806 http://www.ebi.ac.uk/interpro/entry/IPR032806 KEGG_Gene ecj:JW3451 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3451 KEGG_Gene eco:b3484 http://www.genome.jp/dbget-bin/www_bget?eco:b3484 OMA EGWKDIK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EGWKDIK PSORT swissprot:YHHI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHHI_ECOLI PSORT-B swissprot:YHHI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHHI_ECOLI PSORT2 swissprot:YHHI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHHI_ECOLI Pfam PF01609 http://pfam.xfam.org/family/PF01609 Pfam PF13808 http://pfam.xfam.org/family/PF13808 Phobius swissprot:YHHI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHHI_ECOLI PhylomeDB P28912 http://phylomedb.org/?seqid=P28912 ProteinModelPortal P28912 http://www.proteinmodelportal.org/query/uniprot/P28912 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7868617 http://www.ncbi.nlm.nih.gov/pubmed/7868617 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 8387990 http://www.ncbi.nlm.nih.gov/pubmed/8387990 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417941 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417941 RefSeq WP_000420980 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000420980 SMR P28912 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P28912 STRING 511145.b3484 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3484&targetmode=cogs UniProtKB YHHI_ECOLI http://www.uniprot.org/uniprot/YHHI_ECOLI UniProtKB-AC P28912 http://www.uniprot.org/uniprot/P28912 charge swissprot:YHHI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHHI_ECOLI eggNOG COG5433 http://eggnogapi.embl.de/nog_data/html/tree/COG5433 eggNOG ENOG410600T http://eggnogapi.embl.de/nog_data/html/tree/ENOG410600T epestfind swissprot:YHHI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHHI_ECOLI garnier swissprot:YHHI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHHI_ECOLI helixturnhelix swissprot:YHHI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHHI_ECOLI hmoment swissprot:YHHI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHHI_ECOLI iep swissprot:YHHI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHHI_ECOLI inforesidue swissprot:YHHI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHHI_ECOLI octanol swissprot:YHHI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHHI_ECOLI pepcoil swissprot:YHHI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHHI_ECOLI pepdigest swissprot:YHHI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHHI_ECOLI pepinfo swissprot:YHHI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHHI_ECOLI pepnet swissprot:YHHI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHHI_ECOLI pepstats swissprot:YHHI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHHI_ECOLI pepwheel swissprot:YHHI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHHI_ECOLI pepwindow swissprot:YHHI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHHI_ECOLI sigcleave swissprot:YHHI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHHI_ECOLI ## Database ID URL or Descriptions # AltName LPOB_ECOLI Lipoprotein activator of PBP from the outer membrane B # BioGrid 4263027 150 # DISRUPTION PHENOTYPE LPOB_ECOLI Mutant shows sensitivity to many beta- lactams. Absence of both LpoA and LpoB leads to a decrease in peptide cross-linking and to cell lysis. {ECO 0000269|PubMed 21183073, ECO 0000269|PubMed 21183074}. # EcoGene EG13431 lpoB # FUNCTION LPOB_ECOLI Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b). Stimulates transpeptidase and transglycosylase activities of PBP1b in vitro. May also contribute to outer membrane constriction during cell division, in complex with PBP1b. {ECO 0000269|PubMed 21183073, ECO 0000269|PubMed 21183074}. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_component GO:0031241 periplasmic side of cell outer membrane; IDA:UniProtKB. # GO_function GO:0008047 enzyme activator activity; IDA:EcoCyc. # GO_function GO:0019899 enzyme binding; IPI:EcoCyc. # GO_function GO:0030234 enzyme regulator activity; IDA:UniProtKB. # GO_process GO:0008360 regulation of cell shape; IEA:UniProtKB-KW. # GO_process GO:0009252 peptidoglycan biosynthetic process; IDA:UniProtKB. # GO_process GO:0043085 positive regulation of catalytic activity; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0019899 enzyme binding # GOslim_function GO:0030234 enzyme regulator activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # HAMAP MF_01889 LpoB # INTERACTION LPOB_ECOLI P02919 mrcB; NbExp=4; IntAct=EBI-3405489, EBI-909769; # IntAct P0AB38 9 # InterPro IPR014094 LpoB # Organism LPOB_ECOLI Escherichia coli (strain K12) # PATRIC 32117453 VBIEscCol129921_1149 # PIR F64854 F64854 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF13036 LpoB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LPOB_ECOLI Penicillin-binding protein activator LpoB # RefSeq NP_415623 NC_000913.3 # RefSeq WP_000164439 NZ_LN832404.1 # SIMILARITY Belongs to the LpoB family. {ECO 0000305}. # SUBCELLULAR LOCATION LPOB_ECOLI Cell outer membrane {ECO 0000269|PubMed 21183073, ECO 0000269|PubMed 21183074}; Lipid- anchor {ECO 0000269|PubMed 21183073, ECO 0000269|PubMed 21183074}; Periplasmic side {ECO 0000269|PubMed 21183073, ECO 0000269|PubMed 21183074}. Note=Localizes to the divisome and to the lateral wall. # SUBUNIT LPOB_ECOLI Interacts with PBP1b. {ECO 0000269|PubMed 21183073, ECO 0000269|PubMed 21183074}. # TIGRFAMs TIGR02722 lp_ # eggNOG COG3417 LUCA # eggNOG ENOG4108WEF Bacteria BLAST swissprot:LPOB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LPOB_ECOLI BioCyc ECOL316407:JW5157-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5157-MONOMER BioCyc EcoCyc:G6565-MONOMER http://biocyc.org/getid?id=EcoCyc:G6565-MONOMER BioCyc MetaCyc:G6565-MONOMER http://biocyc.org/getid?id=MetaCyc:G6565-MONOMER COG COG3417 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3417 DOI 10.1016/j.cell.2010.11.037 http://dx.doi.org/10.1016/j.cell.2010.11.037 DOI 10.1016/j.cell.2010.11.038 http://dx.doi.org/10.1016/j.cell.2010.11.038 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3205 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3205 EcoGene EG13431 http://www.ecogene.org/geneInfo.php?eg_id=EG13431 EnsemblBacteria AAC74189 http://www.ensemblgenomes.org/id/AAC74189 EnsemblBacteria AAC74189 http://www.ensemblgenomes.org/id/AAC74189 EnsemblBacteria BAA35912 http://www.ensemblgenomes.org/id/BAA35912 EnsemblBacteria BAA35912 http://www.ensemblgenomes.org/id/BAA35912 EnsemblBacteria BAA35912 http://www.ensemblgenomes.org/id/BAA35912 EnsemblBacteria b1105 http://www.ensemblgenomes.org/id/b1105 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0031241 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031241 GO_function GO:0008047 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008047 GO_function GO:0019899 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899 GO_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0009252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009252 GO_process GO:0043085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0019899 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899 GOslim_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 948536 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948536 HAMAP MF_01889 http://hamap.expasy.org/unirule/MF_01889 HOGENOM HOG000119084 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000119084&db=HOGENOM6 IntAct P0AB38 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AB38* InterPro IPR014094 http://www.ebi.ac.uk/interpro/entry/IPR014094 KEGG_Gene ecj:JW5157 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5157 KEGG_Gene eco:b1105 http://www.genome.jp/dbget-bin/www_bget?eco:b1105 KEGG_Orthology KO:K07337 http://www.genome.jp/dbget-bin/www_bget?KO:K07337 OMA EIVWSGN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EIVWSGN PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:LPOB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LPOB_ECOLI PSORT-B swissprot:LPOB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LPOB_ECOLI PSORT2 swissprot:LPOB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LPOB_ECOLI Pfam PF13036 http://pfam.xfam.org/family/PF13036 Phobius swissprot:LPOB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LPOB_ECOLI ProteinModelPortal P0AB38 http://www.proteinmodelportal.org/query/uniprot/P0AB38 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21183073 http://www.ncbi.nlm.nih.gov/pubmed/21183073 PubMed 21183074 http://www.ncbi.nlm.nih.gov/pubmed/21183074 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415623 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415623 RefSeq WP_000164439 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000164439 SMR P0AB38 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AB38 STRING 511145.b1105 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1105&targetmode=cogs STRING COG3417 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3417&targetmode=cogs TIGRFAMs TIGR02722 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02722 UniProtKB LPOB_ECOLI http://www.uniprot.org/uniprot/LPOB_ECOLI UniProtKB-AC P0AB38 http://www.uniprot.org/uniprot/P0AB38 charge swissprot:LPOB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LPOB_ECOLI eggNOG COG3417 http://eggnogapi.embl.de/nog_data/html/tree/COG3417 eggNOG ENOG4108WEF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108WEF epestfind swissprot:LPOB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LPOB_ECOLI garnier swissprot:LPOB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LPOB_ECOLI helixturnhelix swissprot:LPOB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LPOB_ECOLI hmoment swissprot:LPOB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LPOB_ECOLI iep swissprot:LPOB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LPOB_ECOLI inforesidue swissprot:LPOB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LPOB_ECOLI octanol swissprot:LPOB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LPOB_ECOLI pepcoil swissprot:LPOB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LPOB_ECOLI pepdigest swissprot:LPOB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LPOB_ECOLI pepinfo swissprot:LPOB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LPOB_ECOLI pepnet swissprot:LPOB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LPOB_ECOLI pepstats swissprot:LPOB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LPOB_ECOLI pepwheel swissprot:LPOB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LPOB_ECOLI pepwindow swissprot:LPOB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LPOB_ECOLI sigcleave swissprot:LPOB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LPOB_ECOLI ## Database ID URL or Descriptions # BioGrid 4263171 10 # EcoGene EG13548 ykfB # Organism YKFB_ECOLI Escherichia coli (strain K12) # PATRIC 32115617 VBIEscCol129921_0252 # PIR B64750 B64750 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YKFB_ECOLI Uncharacterized protein YkfB # RefSeq NP_414784 NC_000913.3 # RefSeq WP_001547765 NZ_LN832404.1 # SIMILARITY To E.coli YfjT. {ECO 0000305}. # eggNOG ENOG4106J9S Bacteria # eggNOG ENOG410Y9JJ LUCA BLAST swissprot:YKFB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YKFB_ECOLI BioCyc ECOL316407:JW0239-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0239-MONOMER BioCyc EcoCyc:G6125-MONOMER http://biocyc.org/getid?id=EcoCyc:G6125-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EchoBASE EB3318 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3318 EcoGene EG13548 http://www.ecogene.org/geneInfo.php?eg_id=EG13548 EnsemblBacteria AAC73353 http://www.ensemblgenomes.org/id/AAC73353 EnsemblBacteria AAC73353 http://www.ensemblgenomes.org/id/AAC73353 EnsemblBacteria BAA77919 http://www.ensemblgenomes.org/id/BAA77919 EnsemblBacteria BAA77919 http://www.ensemblgenomes.org/id/BAA77919 EnsemblBacteria BAA77919 http://www.ensemblgenomes.org/id/BAA77919 EnsemblBacteria b0250 http://www.ensemblgenomes.org/id/b0250 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946846 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946846 HOGENOM HOG000001687 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000001687&db=HOGENOM6 KEGG_Gene ecj:JW0239 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0239 KEGG_Gene eco:b0250 http://www.genome.jp/dbget-bin/www_bget?eco:b0250 PSORT swissprot:YKFB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YKFB_ECOLI PSORT-B swissprot:YKFB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YKFB_ECOLI PSORT2 swissprot:YKFB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YKFB_ECOLI Phobius swissprot:YKFB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YKFB_ECOLI ProteinModelPortal P77162 http://www.proteinmodelportal.org/query/uniprot/P77162 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414784 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414784 RefSeq WP_001547765 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001547765 STRING 511145.b0250 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0250&targetmode=cogs UniProtKB YKFB_ECOLI http://www.uniprot.org/uniprot/YKFB_ECOLI UniProtKB-AC P77162 http://www.uniprot.org/uniprot/P77162 charge swissprot:YKFB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YKFB_ECOLI eggNOG ENOG4106J9S http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106J9S eggNOG ENOG410Y9JJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y9JJ epestfind swissprot:YKFB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YKFB_ECOLI garnier swissprot:YKFB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YKFB_ECOLI helixturnhelix swissprot:YKFB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YKFB_ECOLI hmoment swissprot:YKFB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YKFB_ECOLI iep swissprot:YKFB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YKFB_ECOLI inforesidue swissprot:YKFB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YKFB_ECOLI octanol swissprot:YKFB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YKFB_ECOLI pepcoil swissprot:YKFB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YKFB_ECOLI pepdigest swissprot:YKFB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YKFB_ECOLI pepinfo swissprot:YKFB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YKFB_ECOLI pepnet swissprot:YKFB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YKFB_ECOLI pepstats swissprot:YKFB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YKFB_ECOLI pepwheel swissprot:YKFB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YKFB_ECOLI pepwindow swissprot:YKFB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YKFB_ECOLI sigcleave swissprot:YKFB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YKFB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260261 8 # EcoGene EG13946 ydhL # InterPro IPR010710 DUF1289 # Organism YDHL_ECOLI Escherichia coli (strain K12) # PIR B64922 B64922 # Pfam PF06945 DUF1289 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDHL_ECOLI Uncharacterized protein YdhL # RefSeq NP_416165 NC_000913.3 # RefSeq WP_000840481 NZ_LN832404.1 # eggNOG COG3313 LUCA # eggNOG ENOG4105XZD Bacteria BLAST swissprot:YDHL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDHL_ECOLI BioCyc ECOL316407:JW5827-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5827-MONOMER BioCyc EcoCyc:G6888-MONOMER http://biocyc.org/getid?id=EcoCyc:G6888-MONOMER COG COG3313 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3313 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3704 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3704 EcoGene EG13946 http://www.ecogene.org/geneInfo.php?eg_id=EG13946 EnsemblBacteria AAC74720 http://www.ensemblgenomes.org/id/AAC74720 EnsemblBacteria AAC74720 http://www.ensemblgenomes.org/id/AAC74720 EnsemblBacteria BAE76491 http://www.ensemblgenomes.org/id/BAE76491 EnsemblBacteria BAE76491 http://www.ensemblgenomes.org/id/BAE76491 EnsemblBacteria BAE76491 http://www.ensemblgenomes.org/id/BAE76491 EnsemblBacteria b1648 http://www.ensemblgenomes.org/id/b1648 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946168 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946168 HOGENOM HOG000126537 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126537&db=HOGENOM6 InParanoid P64474 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P64474 InterPro IPR010710 http://www.ebi.ac.uk/interpro/entry/IPR010710 KEGG_Gene ecj:JW5827 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5827 KEGG_Gene eco:b1648 http://www.genome.jp/dbget-bin/www_bget?eco:b1648 KEGG_Orthology KO:K06938 http://www.genome.jp/dbget-bin/www_bget?KO:K06938 OMA GYCRGCM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GYCRGCM PSORT swissprot:YDHL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDHL_ECOLI PSORT-B swissprot:YDHL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDHL_ECOLI PSORT2 swissprot:YDHL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDHL_ECOLI Pfam PF06945 http://pfam.xfam.org/family/PF06945 Phobius swissprot:YDHL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDHL_ECOLI PhylomeDB P64474 http://phylomedb.org/?seqid=P64474 ProteinModelPortal P64474 http://www.proteinmodelportal.org/query/uniprot/P64474 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416165 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416165 RefSeq WP_000840481 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000840481 STRING 511145.b1648 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1648&targetmode=cogs STRING COG3313 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3313&targetmode=cogs UniProtKB YDHL_ECOLI http://www.uniprot.org/uniprot/YDHL_ECOLI UniProtKB-AC P64474 http://www.uniprot.org/uniprot/P64474 charge swissprot:YDHL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDHL_ECOLI eggNOG COG3313 http://eggnogapi.embl.de/nog_data/html/tree/COG3313 eggNOG ENOG4105XZD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105XZD epestfind swissprot:YDHL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDHL_ECOLI garnier swissprot:YDHL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDHL_ECOLI helixturnhelix swissprot:YDHL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDHL_ECOLI hmoment swissprot:YDHL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDHL_ECOLI iep swissprot:YDHL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDHL_ECOLI inforesidue swissprot:YDHL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDHL_ECOLI octanol swissprot:YDHL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDHL_ECOLI pepcoil swissprot:YDHL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDHL_ECOLI pepdigest swissprot:YDHL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDHL_ECOLI pepinfo swissprot:YDHL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDHL_ECOLI pepnet swissprot:YDHL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDHL_ECOLI pepstats swissprot:YDHL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDHL_ECOLI pepwheel swissprot:YDHL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDHL_ECOLI pepwindow swissprot:YDHL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDHL_ECOLI sigcleave swissprot:YDHL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDHL_ECOLI ## Database ID URL or Descriptions # BioGrid 4259602 108 # CDD cd06170 LuxR_C_like # DISRUPTION PHENOTYPE A double sdiA/ydiV deletion mutant leads to decreased cAMP levels which inhibits quorum sensing system 2. {ECO:0000269|PubMed 18560382}. # DOMAIN SDIA_ECOLI Binding to the autoinducer occurs via the N-terminal 170 residues; as E.coli does not produce LuxI autoinducers endogenously it should be able to bind to a number of different AI-1 autoinducers, which would enable it to detect other bacteria. This was shown to be the case. # EcoGene EG10935 sdiA # FUNCTION SDIA_ECOLI Activates cell division by specifically increasing transcription from one of the two promoters that lie immediately upstream of the ftsQAZ gene cluster. Activates ydiV expression in response to extracellular autoinducer AI-1 (Vibrio fischeri autoinducer oxoC6). {ECO 0000269|PubMed 18560382, ECO 0000269|PubMed 1915297}. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0007049 cell cycle; IEA:UniProtKB-KW. # GO_process GO:0032467 positive regulation of cytokinesis; IMP:EcoCyc. # GO_process GO:0051301 cell division; IEA:UniProtKB-KW. # GO_process GO:2000144 positive regulation of DNA-templated transcription, initiation; IDA:EcoCyc. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0007049 cell cycle # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0051301 cell division # Gene3D 1.10.10.10 -; 1. # Gene3D 3.30.450.80 -; 1. # INDUCTION Repressed by glucose. {ECO:0000269|PubMed 18560382}. # IntAct P07026 8 # InterPro IPR000792 Tscrpt_reg_LuxR_C # InterPro IPR005143 TF_LuxR_autoind-bd_dom # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR016032 Sig_transdc_resp-reg_C-effctor # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko03000 Transcription factors # KEGG_Pathway ko02020 Two-component system # Organism SDIA_ECOLI Escherichia coli (strain K12) # PATRIC 32119167 VBIEscCol129921_1998 # PDB 2AVX NMR; -; A=1-171 # PDB 4LFU X-ray; 2.26 A; A=1-240 # PDB 4LGW X-ray; 2.70 A; A=1-240 # PIR A64955 QQECU1 # PRINTS PR00038 HTHLUXR # PROSITE PS00622 HTH_LUXR_1 # PROSITE PS50043 HTH_LUXR_2 # Pfam PF00196 GerE # Pfam PF03472 Autoind_bind # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SDIA_ECOLI Regulatory protein SdiA # RefSeq NP_416426 NC_000913.3 # RefSeq WP_001152715 NZ_LN832404.1 # SIMILARITY Contains 1 HTH luxR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00411}. # SMART SM00421 HTH_LUXR # SUPFAM SSF46894 SSF46894 # SUPFAM SSF75516 SSF75516 # eggNOG COG2771 LUCA # eggNOG ENOG4105VJY Bacteria BLAST swissprot:SDIA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SDIA_ECOLI BioCyc ECOL316407:JW1901-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1901-MONOMER BioCyc EcoCyc:PD02198 http://biocyc.org/getid?id=EcoCyc:PD02198 COG COG2771 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2771 DOI 10.1016/j.jmb.2005.10.041 http://dx.doi.org/10.1016/j.jmb.2005.10.041 DOI 10.1038/cr.2008.67 http://dx.doi.org/10.1038/cr.2008.67 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/nar/14.5.2301 http://dx.doi.org/10.1093/nar/14.5.2301 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X03691 http://www.ebi.ac.uk/ena/data/view/X03691 EchoBASE EB0928 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0928 EcoGene EG10935 http://www.ecogene.org/geneInfo.php?eg_id=EG10935 EnsemblBacteria AAC74983 http://www.ensemblgenomes.org/id/AAC74983 EnsemblBacteria AAC74983 http://www.ensemblgenomes.org/id/AAC74983 EnsemblBacteria BAA15736 http://www.ensemblgenomes.org/id/BAA15736 EnsemblBacteria BAA15736 http://www.ensemblgenomes.org/id/BAA15736 EnsemblBacteria BAA15736 http://www.ensemblgenomes.org/id/BAA15736 EnsemblBacteria b1916 http://www.ensemblgenomes.org/id/b1916 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GO_process GO:0032467 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032467 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GO_process GO:2000144 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000144 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 3.30.450.80 http://www.cathdb.info/version/latest/superfamily/3.30.450.80 GeneID 946421 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946421 HOGENOM HOG000111053 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000111053&db=HOGENOM6 InParanoid P07026 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P07026 IntAct P07026 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P07026* InterPro IPR000792 http://www.ebi.ac.uk/interpro/entry/IPR000792 InterPro IPR005143 http://www.ebi.ac.uk/interpro/entry/IPR005143 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR016032 http://www.ebi.ac.uk/interpro/entry/IPR016032 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW1901 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1901 KEGG_Gene eco:b1916 http://www.genome.jp/dbget-bin/www_bget?eco:b1916 KEGG_Orthology KO:K07782 http://www.genome.jp/dbget-bin/www_bget?KO:K07782 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA AWMSHYQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AWMSHYQ PDB 2AVX http://www.ebi.ac.uk/pdbe-srv/view/entry/2AVX PDB 4LFU http://www.ebi.ac.uk/pdbe-srv/view/entry/4LFU PDB 4LGW http://www.ebi.ac.uk/pdbe-srv/view/entry/4LGW PDBsum 2AVX http://www.ebi.ac.uk/pdbsum/2AVX PDBsum 4LFU http://www.ebi.ac.uk/pdbsum/4LFU PDBsum 4LGW http://www.ebi.ac.uk/pdbsum/4LGW PRINTS PR00038 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00038 PROSITE PS00622 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00622 PROSITE PS50043 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50043 PSORT swissprot:SDIA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SDIA_ECOLI PSORT-B swissprot:SDIA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SDIA_ECOLI PSORT2 swissprot:SDIA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SDIA_ECOLI Pfam PF00196 http://pfam.xfam.org/family/PF00196 Pfam PF03472 http://pfam.xfam.org/family/PF03472 Phobius swissprot:SDIA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SDIA_ECOLI PhylomeDB P07026 http://phylomedb.org/?seqid=P07026 ProteinModelPortal P07026 http://www.proteinmodelportal.org/query/uniprot/P07026 PubMed 16307757 http://www.ncbi.nlm.nih.gov/pubmed/16307757 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18560382 http://www.ncbi.nlm.nih.gov/pubmed/18560382 PubMed 1915297 http://www.ncbi.nlm.nih.gov/pubmed/1915297 PubMed 3515318 http://www.ncbi.nlm.nih.gov/pubmed/3515318 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416426 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416426 RefSeq WP_001152715 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001152715 SMART SM00421 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00421 SMR P07026 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P07026 STRING 511145.b1916 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1916&targetmode=cogs STRING COG2771 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2771&targetmode=cogs SUPFAM SSF46894 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46894 SUPFAM SSF75516 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF75516 UniProtKB SDIA_ECOLI http://www.uniprot.org/uniprot/SDIA_ECOLI UniProtKB-AC P07026 http://www.uniprot.org/uniprot/P07026 charge swissprot:SDIA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SDIA_ECOLI eggNOG COG2771 http://eggnogapi.embl.de/nog_data/html/tree/COG2771 eggNOG ENOG4105VJY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VJY epestfind swissprot:SDIA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SDIA_ECOLI garnier swissprot:SDIA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SDIA_ECOLI helixturnhelix swissprot:SDIA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SDIA_ECOLI hmoment swissprot:SDIA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SDIA_ECOLI iep swissprot:SDIA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SDIA_ECOLI inforesidue swissprot:SDIA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SDIA_ECOLI octanol swissprot:SDIA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SDIA_ECOLI pepcoil swissprot:SDIA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SDIA_ECOLI pepdigest swissprot:SDIA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SDIA_ECOLI pepinfo swissprot:SDIA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SDIA_ECOLI pepnet swissprot:SDIA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SDIA_ECOLI pepstats swissprot:SDIA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SDIA_ECOLI pepwheel swissprot:SDIA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SDIA_ECOLI pepwindow swissprot:SDIA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SDIA_ECOLI sigcleave swissprot:SDIA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SDIA_ECOLI ## Database ID URL or Descriptions # BioGrid 4263112 406 # ENZYME REGULATION XERC_ECOLI During recombination, the heterotetrameric complex catalyzes two consecutive pairs of strand exchanges, implying that specific pairs of active sites are sequentially switched on and off in the recombinase tetramer to ensure that appropriate DNA strands will be exchanged at both reaction steps. FtsK plays a central role in this catalytic state switch that turns recombinase on and off reciprocally. The reciprocal C- terminal interaction between XerC and XerD may also participate in the enzymatic switch process. {ECO 0000269|PubMed 10635320, ECO 0000269|PubMed 11832210}. # EcoGene EG11069 xerC # FUNCTION XERC_ECOLI Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Binds cooperatively to specific DNA consensus sequences that are separated from XerD binding sites by a short central region, forming the heterotetrameric XerC-XerD complex that recombines DNA substrates. The complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids at ColE1 xer (or cer) and pSC101 (or psi) sites. In the complex XerC specifically exchanges the top DNA strands (By similarity). {ECO 0000250, ECO 0000269|PubMed 10037776, ECO 0000269|PubMed 7744017, ECO 0000269|PubMed 9268326}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_component GO:0048476 Holliday junction resolvase complex; IDA:EcoliWiki. # GO_function GO:0003677 DNA binding; IDA:EcoliWiki. # GO_function GO:0009009 site-specific recombinase activity; IDA:EcoliWiki. # GO_function GO:0009037 tyrosine-based site-specific recombinase activity; IDA:EcoliWiki. # GO_process GO:0006276 plasmid maintenance; IMP:EcoliWiki. # GO_process GO:0006313 transposition, DNA-mediated; IEA:UniProtKB-HAMAP. # GO_process GO:0007049 cell cycle; IEA:UniProtKB-KW. # GO_process GO:0007059 chromosome segregation; IEA:UniProtKB-HAMAP. # GO_process GO:0042150 plasmid recombination; IMP:EcoliWiki. # GO_process GO:0051301 cell division; IEA:UniProtKB-KW. # GO_process GO:0071139 resolution of recombination intermediates; IDA:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0007049 cell cycle # GOslim_process GO:0007059 chromosome segregation # GOslim_process GO:0008150 biological_process # GOslim_process GO:0032196 transposition # GOslim_process GO:0051301 cell division # Gene3D 1.10.150.130 -; 1. # Gene3D 1.10.443.10 -; 1. # HAMAP MF_01808 Recomb_XerC_XerD # INTERACTION XERC_ECOLI P0A9E0 araC; NbExp=3; IntAct=EBI-1133806, EBI-1113479; P77551 rzpR; NbExp=2; IntAct=EBI-1133806, EBI-9135212; # IntAct P0A8P6 9 # InterPro IPR002104 Integrase_catalytic # InterPro IPR004107 Integrase_SAM-like_N # InterPro IPR010998 Integrase_Lambda-type_N # InterPro IPR011010 DNA_brk_join_enz # InterPro IPR011931 Recomb_XerC # InterPro IPR013762 Integrase-like_cat # InterPro IPR023009 Tyrosine_recombinase_XerC/XerD # InterPro IPR023109 Integrase_recombinase_N # KEGG_Brite ko03036 Chromosome # Organism XERC_ECOLI Escherichia coli (strain K12) # PATRIC 32123123 VBIEscCol129921_3927 # PDB 5DCF X-ray; 2.30 A; A=111-298 # PIR C37841 C37841 # Pfam PF00589 Phage_integrase # Pfam PF02899 Phage_int_SAM_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName XERC_ECOLI Tyrosine recombinase XerC # RefSeq NP_418256 NC_000913.3 # RefSeq WP_000130691 NZ_LN832404.1 # SIMILARITY Belongs to the 'phage' integrase family. XerC subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION XERC_ECOLI Cytoplasm. Note=Associated with DNA. # SUBUNIT Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD, in which XerC interacts with XerD via its C-terminal region, XerD interacts with XerC via its C-terminal region and so on. {ECO:0000269|PubMed 10361305}. # SUPFAM SSF47823 SSF47823 # SUPFAM SSF56349 SSF56349 # TIGRFAMs TIGR02224 recomb_XerC # eggNOG COG4973 LUCA # eggNOG ENOG4108IYS Bacteria BLAST swissprot:XERC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:XERC_ECOLI BioCyc ECOL316407:JW3784-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3784-MONOMER BioCyc EcoCyc:EG11069-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11069-MONOMER COG COG0582 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0582 DIP DIP-726N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-726N DOI 10.1016/0092-8674(93)80076-Q http://dx.doi.org/10.1016/0092-8674(93)80076-Q DOI 10.1016/S0092-8674(02)00624-4 http://dx.doi.org/10.1016/S0092-8674(02)00624-4 DOI 10.1016/S1097-2765(00)80224-5 http://dx.doi.org/10.1016/S1097-2765(00)80224-5 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1999.01418.x http://dx.doi.org/10.1046/j.1365-2958.1999.01418.x DOI 10.1074/jbc.272.35.21927 http://dx.doi.org/10.1074/jbc.272.35.21927 DOI 10.1074/jbc.274.10.6763 http://dx.doi.org/10.1074/jbc.274.10.6763 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M38257 http://www.ebi.ac.uk/ena/data/view/M38257 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1062 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1062 EcoGene EG11069 http://www.ecogene.org/geneInfo.php?eg_id=EG11069 EnsemblBacteria AAC76814 http://www.ensemblgenomes.org/id/AAC76814 EnsemblBacteria AAC76814 http://www.ensemblgenomes.org/id/AAC76814 EnsemblBacteria BAE77489 http://www.ensemblgenomes.org/id/BAE77489 EnsemblBacteria BAE77489 http://www.ensemblgenomes.org/id/BAE77489 EnsemblBacteria BAE77489 http://www.ensemblgenomes.org/id/BAE77489 EnsemblBacteria b3811 http://www.ensemblgenomes.org/id/b3811 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0048476 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048476 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0009009 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009009 GO_function GO:0009037 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009037 GO_process GO:0006276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006276 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GO_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GO_process GO:0007059 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007059 GO_process GO:0042150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042150 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GO_process GO:0071139 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071139 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GOslim_process GO:0007059 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007059 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 Gene3D 1.10.150.130 http://www.cathdb.info/version/latest/superfamily/1.10.150.130 Gene3D 1.10.443.10 http://www.cathdb.info/version/latest/superfamily/1.10.443.10 GeneID 948355 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948355 HAMAP MF_01808 http://hamap.expasy.org/unirule/MF_01808 HOGENOM HOG000045294 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000045294&db=HOGENOM6 InParanoid P0A8P6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8P6 IntAct P0A8P6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8P6* InterPro IPR002104 http://www.ebi.ac.uk/interpro/entry/IPR002104 InterPro IPR004107 http://www.ebi.ac.uk/interpro/entry/IPR004107 InterPro IPR010998 http://www.ebi.ac.uk/interpro/entry/IPR010998 InterPro IPR011010 http://www.ebi.ac.uk/interpro/entry/IPR011010 InterPro IPR011931 http://www.ebi.ac.uk/interpro/entry/IPR011931 InterPro IPR013762 http://www.ebi.ac.uk/interpro/entry/IPR013762 InterPro IPR023009 http://www.ebi.ac.uk/interpro/entry/IPR023009 InterPro IPR023109 http://www.ebi.ac.uk/interpro/entry/IPR023109 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene ecj:JW3784 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3784 KEGG_Gene eco:b3811 http://www.genome.jp/dbget-bin/www_bget?eco:b3811 KEGG_Orthology KO:K03733 http://www.genome.jp/dbget-bin/www_bget?KO:K03733 OMA ERQVSPH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ERQVSPH PDB 5DCF http://www.ebi.ac.uk/pdbe-srv/view/entry/5DCF PDBsum 5DCF http://www.ebi.ac.uk/pdbsum/5DCF PSORT swissprot:XERC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:XERC_ECOLI PSORT-B swissprot:XERC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:XERC_ECOLI PSORT2 swissprot:XERC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:XERC_ECOLI Pfam PF00589 http://pfam.xfam.org/family/PF00589 Pfam PF02899 http://pfam.xfam.org/family/PF02899 Phobius swissprot:XERC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:XERC_ECOLI PhylomeDB P0A8P6 http://phylomedb.org/?seqid=P0A8P6 ProteinModelPortal P0A8P6 http://www.proteinmodelportal.org/query/uniprot/P0A8P6 PubMed 10037776 http://www.ncbi.nlm.nih.gov/pubmed/10037776 PubMed 10361305 http://www.ncbi.nlm.nih.gov/pubmed/10361305 PubMed 10635320 http://www.ncbi.nlm.nih.gov/pubmed/10635320 PubMed 11832210 http://www.ncbi.nlm.nih.gov/pubmed/11832210 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2254268 http://www.ncbi.nlm.nih.gov/pubmed/2254268 PubMed 7744017 http://www.ncbi.nlm.nih.gov/pubmed/7744017 PubMed 8402918 http://www.ncbi.nlm.nih.gov/pubmed/8402918 PubMed 9268326 http://www.ncbi.nlm.nih.gov/pubmed/9268326 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418256 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418256 RefSeq WP_000130691 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000130691 SMR P0A8P6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8P6 STRING 511145.b3811 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3811&targetmode=cogs STRING COG0582 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0582&targetmode=cogs SUPFAM SSF47823 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47823 SUPFAM SSF56349 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56349 TIGRFAMs TIGR02224 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02224 UniProtKB XERC_ECOLI http://www.uniprot.org/uniprot/XERC_ECOLI UniProtKB-AC P0A8P6 http://www.uniprot.org/uniprot/P0A8P6 charge swissprot:XERC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:XERC_ECOLI eggNOG COG4973 http://eggnogapi.embl.de/nog_data/html/tree/COG4973 eggNOG ENOG4108IYS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108IYS epestfind swissprot:XERC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:XERC_ECOLI garnier swissprot:XERC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:XERC_ECOLI helixturnhelix swissprot:XERC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:XERC_ECOLI hmoment swissprot:XERC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:XERC_ECOLI iep swissprot:XERC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:XERC_ECOLI inforesidue swissprot:XERC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:XERC_ECOLI octanol swissprot:XERC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:XERC_ECOLI pepcoil swissprot:XERC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:XERC_ECOLI pepdigest swissprot:XERC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:XERC_ECOLI pepinfo swissprot:XERC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:XERC_ECOLI pepnet swissprot:XERC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:XERC_ECOLI pepstats swissprot:XERC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:XERC_ECOLI pepwheel swissprot:XERC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:XERC_ECOLI pepwindow swissprot:XERC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:XERC_ECOLI sigcleave swissprot:XERC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:XERC_ECOLI ## Database ID URL or Descriptions # BioGrid 4259254 11 # EcoGene EG12434 ygiM # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # IntAct P0ADT8 3 # InterPro IPR003646 SH3-like_bac-type # InterPro IPR016476 SH3_dom_pro # Organism YGIM_ECOLI Escherichia coli (strain K12) # PATRIC 32121522 VBIEscCol129921_3148 # PIR E65093 E65093 # PIRSF PIRSF006158 UCP006158_SH3 # PROSITE PS51781 SH3B # Pfam PF08239 SH3_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGIM_ECOLI Uncharacterized protein YgiM # RefSeq NP_417527 NC_000913.3 # RefSeq WP_001125331 NZ_LN832404.1 # SIMILARITY Contains 1 SH3b domain. {ECO:0000255|PROSITE- ProRule PRU01117}. # SIMILARITY To H.influenzae HI_1605. {ECO 0000305}. # SMART SM00287 SH3b # SUBCELLULAR LOCATION YGIM_ECOLI Membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. # TIGRFAMs TIGR04211 SH3_and_anchor # eggNOG COG3103 LUCA # eggNOG ENOG4106MWK Bacteria BLAST swissprot:YGIM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGIM_ECOLI BioCyc ECOL316407:JW3027-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3027-MONOMER BioCyc EcoCyc:EG12434-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12434-MONOMER COG COG3103 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3103 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M12788 http://www.ebi.ac.uk/ena/data/view/M12788 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28379 http://www.ebi.ac.uk/ena/data/view/U28379 EchoBASE EB2330 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2330 EcoGene EG12434 http://www.ecogene.org/geneInfo.php?eg_id=EG12434 EnsemblBacteria AAC76091 http://www.ensemblgenomes.org/id/AAC76091 EnsemblBacteria AAC76091 http://www.ensemblgenomes.org/id/AAC76091 EnsemblBacteria BAE77106 http://www.ensemblgenomes.org/id/BAE77106 EnsemblBacteria BAE77106 http://www.ensemblgenomes.org/id/BAE77106 EnsemblBacteria BAE77106 http://www.ensemblgenomes.org/id/BAE77106 EnsemblBacteria b3055 http://www.ensemblgenomes.org/id/b3055 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GeneID 947555 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947555 HOGENOM HOG000272218 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000272218&db=HOGENOM6 InParanoid P0ADT8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADT8 IntAct P0ADT8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADT8* InterPro IPR003646 http://www.ebi.ac.uk/interpro/entry/IPR003646 InterPro IPR016476 http://www.ebi.ac.uk/interpro/entry/IPR016476 KEGG_Gene ecj:JW3027 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3027 KEGG_Gene eco:b3055 http://www.genome.jp/dbget-bin/www_bget?eco:b3055 KEGG_Orthology KO:K07184 http://www.genome.jp/dbget-bin/www_bget?KO:K07184 OMA HKGREGW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HKGREGW PROSITE PS51781 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51781 PSORT swissprot:YGIM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGIM_ECOLI PSORT-B swissprot:YGIM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGIM_ECOLI PSORT2 swissprot:YGIM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGIM_ECOLI Pfam PF08239 http://pfam.xfam.org/family/PF08239 Phobius swissprot:YGIM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGIM_ECOLI ProteinModelPortal P0ADT8 http://www.proteinmodelportal.org/query/uniprot/P0ADT8 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3009457 http://www.ncbi.nlm.nih.gov/pubmed/3009457 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417527 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417527 RefSeq WP_001125331 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001125331 SMART SM00287 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00287 SMR P0ADT8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADT8 STRING 511145.b3055 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3055&targetmode=cogs STRING COG3103 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3103&targetmode=cogs TIGRFAMs TIGR04211 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR04211 UniProtKB YGIM_ECOLI http://www.uniprot.org/uniprot/YGIM_ECOLI UniProtKB-AC P0ADT8 http://www.uniprot.org/uniprot/P0ADT8 charge swissprot:YGIM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGIM_ECOLI eggNOG COG3103 http://eggnogapi.embl.de/nog_data/html/tree/COG3103 eggNOG ENOG4106MWK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106MWK epestfind swissprot:YGIM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGIM_ECOLI garnier swissprot:YGIM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGIM_ECOLI helixturnhelix swissprot:YGIM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGIM_ECOLI hmoment swissprot:YGIM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGIM_ECOLI iep swissprot:YGIM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGIM_ECOLI inforesidue swissprot:YGIM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGIM_ECOLI octanol swissprot:YGIM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGIM_ECOLI pepcoil swissprot:YGIM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGIM_ECOLI pepdigest swissprot:YGIM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGIM_ECOLI pepinfo swissprot:YGIM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGIM_ECOLI pepnet swissprot:YGIM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGIM_ECOLI pepstats swissprot:YGIM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGIM_ECOLI pepwheel swissprot:YGIM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGIM_ECOLI pepwindow swissprot:YGIM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGIM_ECOLI sigcleave swissprot:YGIM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGIM_ECOLI ## Database ID URL or Descriptions # BioGrid 4262998 140 # EcoGene EG11122 yciB # FUNCTION YCIB_ECOLI Involved in cell division; probably involved in intracellular septation. {ECO 0000255|HAMAP-Rule MF_00189}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_process GO:0090529 cell septum assembly; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0022607 cellular component assembly # HAMAP MF_00189 Intracell_septation_prot_A # InterPro IPR006008 Intracell_sepatation_prot_A # Organism YCIB_ECOLI Escherichia coli (strain K12) # PATRIC 32117768 VBIEscCol129921_1304 # PIR S07799 S07799 # PIR T45503 T45503 # Pfam PF04279 IspA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Probable intracellular septation protein A {ECO:0000255|HAMAP-Rule MF_00189} # RefSeq NP_415770 NC_000913.3 # RefSeq WP_000808667 NZ_LN832404.1 # SIMILARITY Belongs to the YciB family. {ECO:0000255|HAMAP- Rule MF_00189}. # SUBCELLULAR LOCATION YCIB_ECOLI Cell inner membrane; Multi-pass membrane protein. # TIGRFAMs TIGR00997 ispZ # eggNOG COG2917 LUCA # eggNOG ENOG4107835 Bacteria BLAST swissprot:YCIB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCIB_ECOLI BioCyc ECOL316407:JW1246-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1246-MONOMER BioCyc EcoCyc:EG11122-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11122-MONOMER COG COG2917 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2917 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U24195 http://www.ebi.ac.uk/ena/data/view/U24195 EMBL U24196 http://www.ebi.ac.uk/ena/data/view/U24196 EMBL U24197 http://www.ebi.ac.uk/ena/data/view/U24197 EMBL U24198 http://www.ebi.ac.uk/ena/data/view/U24198 EMBL U24199 http://www.ebi.ac.uk/ena/data/view/U24199 EMBL U24200 http://www.ebi.ac.uk/ena/data/view/U24200 EMBL U24201 http://www.ebi.ac.uk/ena/data/view/U24201 EMBL U24202 http://www.ebi.ac.uk/ena/data/view/U24202 EMBL U24203 http://www.ebi.ac.uk/ena/data/view/U24203 EMBL U24204 http://www.ebi.ac.uk/ena/data/view/U24204 EMBL U24205 http://www.ebi.ac.uk/ena/data/view/U24205 EMBL U24206 http://www.ebi.ac.uk/ena/data/view/U24206 EMBL X13583 http://www.ebi.ac.uk/ena/data/view/X13583 EchoBASE EB1112 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1112 EcoGene EG11122 http://www.ecogene.org/geneInfo.php?eg_id=EG11122 EnsemblBacteria AAC74336 http://www.ensemblgenomes.org/id/AAC74336 EnsemblBacteria AAC74336 http://www.ensemblgenomes.org/id/AAC74336 EnsemblBacteria BAA14786 http://www.ensemblgenomes.org/id/BAA14786 EnsemblBacteria BAA14786 http://www.ensemblgenomes.org/id/BAA14786 EnsemblBacteria BAA14786 http://www.ensemblgenomes.org/id/BAA14786 EnsemblBacteria b1254 http://www.ensemblgenomes.org/id/b1254 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_process GO:0090529 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090529 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GeneID 946228 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946228 HAMAP MF_00189 http://hamap.expasy.org/unirule/MF_00189 HOGENOM HOG000062588 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000062588&db=HOGENOM6 InParanoid P0A710 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A710 InterPro IPR006008 http://www.ebi.ac.uk/interpro/entry/IPR006008 KEGG_Gene ecj:JW1246 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1246 KEGG_Gene eco:b1254 http://www.genome.jp/dbget-bin/www_bget?eco:b1254 KEGG_Orthology KO:K06190 http://www.genome.jp/dbget-bin/www_bget?KO:K06190 OMA FWVNFKV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FWVNFKV PSORT swissprot:YCIB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCIB_ECOLI PSORT-B swissprot:YCIB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCIB_ECOLI PSORT2 swissprot:YCIB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCIB_ECOLI Pfam PF04279 http://pfam.xfam.org/family/PF04279 Phobius swissprot:YCIB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCIB_ECOLI PhylomeDB P0A710 http://phylomedb.org/?seqid=P0A710 ProteinModelPortal P0A710 http://www.proteinmodelportal.org/query/uniprot/P0A710 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3058546 http://www.ncbi.nlm.nih.gov/pubmed/3058546 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415770 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415770 RefSeq WP_000808667 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000808667 STRING 511145.b1254 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1254&targetmode=cogs STRING COG2917 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2917&targetmode=cogs TIGRFAMs TIGR00997 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00997 UniProtKB YCIB_ECOLI http://www.uniprot.org/uniprot/YCIB_ECOLI UniProtKB-AC P0A710 http://www.uniprot.org/uniprot/P0A710 charge swissprot:YCIB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCIB_ECOLI eggNOG COG2917 http://eggnogapi.embl.de/nog_data/html/tree/COG2917 eggNOG ENOG4107835 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107835 epestfind swissprot:YCIB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCIB_ECOLI garnier swissprot:YCIB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCIB_ECOLI helixturnhelix swissprot:YCIB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCIB_ECOLI hmoment swissprot:YCIB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCIB_ECOLI iep swissprot:YCIB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCIB_ECOLI inforesidue swissprot:YCIB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCIB_ECOLI octanol swissprot:YCIB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCIB_ECOLI pepcoil swissprot:YCIB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCIB_ECOLI pepdigest swissprot:YCIB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCIB_ECOLI pepinfo swissprot:YCIB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCIB_ECOLI pepnet swissprot:YCIB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCIB_ECOLI pepstats swissprot:YCIB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCIB_ECOLI pepwheel swissprot:YCIB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCIB_ECOLI pepwindow swissprot:YCIB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCIB_ECOLI sigcleave swissprot:YCIB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCIB_ECOLI ## Database ID URL or Descriptions # AltName ACOCT_ECOLI Acetyl-coenzyme A transferase # AltName CoA oxalate CoA-transferase # BIOPHYSICOCHEMICAL PROPERTIES ACOCT_ECOLI Kinetic parameters KM=17 uM for acetyl-CoA (at pH 6.7 and 25 degrees Celsius) {ECO 0000269|PubMed 23935849}; KM=22 mM for oxalate (at pH 6.7 and 25 degrees Celsius) {ECO 0000269|PubMed 23935849}; Note=Kcat is 11 sec(-1) for the CoA-transferase activity with acetyl-CoA as substrate (at pH 6.7 and 25 degrees Celsius). Kcat is 15 sec(-1) for the CoA-transferase activity with oxalate as substrate (at pH 6.7 and 25 degrees Celsius).; # BRENDA 2.8.3.19 2026 # BioGrid 4259190 3 # CATALYTIC ACTIVITY Acetyl-CoA + oxalate = acetate + oxalyl-CoA. {ECO:0000269|PubMed 23935849}. # EcoGene EG13284 yfdE # FUNCTION ACOCT_ECOLI Involved in the catabolism of oxalate and in the adapatation to low pH. ACOCT serves to prime the oxalate-induced acid tolerance response (ATR) cycle by producing substrate for oxalyl-CoA decarboxylase (OXC) and formyl-coenzyme A transferase (FCOCT). Catalyzes the reversible conversion of acetyl-CoA and oxalate to oxalyl-CoA and acetate. It can also use formyl-CoA and oxalate to produce oxalyl-CoA and formate with significantly reduced specific activity. {ECO 0000269|PubMed 23935849}. # GO_function ACOCT_ECOLI GO 0036412 acetyl-CoA oxalate CoA-transferase; IDA EcoCyc. # GOslim_function GO:0003674 molecular_function # Gene3D 3.40.50.10540 -; 2. # INDUCTION ACOCT_ECOLI By the acid response regulator EvgA. {ECO 0000269|PubMed 12694615, ECO 0000269|PubMed 23335415}. # IntAct P76518 7 # InterPro IPR003673 CoA-Trfase_fam_III # InterPro IPR023606 CoA-Trfase_III_dom # Organism ACOCT_ECOLI Escherichia coli (strain K12) # PATRIC 32120121 VBIEscCol129921_2469 # PDB 4HL6 X-ray; 2.12 A; A/B/C/D/E/F=1-381 # PIR H65010 H65010 # Pfam PF02515 CoA_transf_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Acetyl-CoA oxalate CoA-transferase # RefSeq NP_416872 NC_000913.3 # RefSeq WP_001296867 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=D14008; Type=Frameshift; Positions=360, 366; Evidence={ECO 0000305}; # SIMILARITY Belongs to the CaiB/BaiF CoA-transferase family. {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 23935849}. # SUPFAM SSF89796 SSF89796 # eggNOG COG1804 LUCA # eggNOG ENOG4105C04 Bacteria BLAST swissprot:ACOCT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ACOCT_ECOLI BioCyc ECOL316407:JW2368-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2368-MONOMER BioCyc EcoCyc:G7234-MONOMER http://biocyc.org/getid?id=EcoCyc:G7234-MONOMER BioCyc MetaCyc:G7234-MONOMER http://biocyc.org/getid?id=MetaCyc:G7234-MONOMER DIP DIP-11994N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11994N DOI 10.1016/0378-1119(94)90733-1 http://dx.doi.org/10.1016/0378-1119(94)90733-1 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2003.03477.x http://dx.doi.org/10.1046/j.1365-2958.2003.03477.x DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01936-12 http://dx.doi.org/10.1128/JB.01936-12 DOI 10.1371/journal.pone.0067901 http://dx.doi.org/10.1371/journal.pone.0067901 EC_number EC:2.8.3.19 http://www.genome.jp/dbget-bin/www_bget?EC:2.8.3.19 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D14008 http://www.ebi.ac.uk/ena/data/view/D14008 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.8.3.19 http://enzyme.expasy.org/EC/2.8.3.19 EchoBASE EB3069 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3069 EcoGene EG13284 http://www.ecogene.org/geneInfo.php?eg_id=EG13284 EnsemblBacteria AAC75430 http://www.ensemblgenomes.org/id/AAC75430 EnsemblBacteria AAC75430 http://www.ensemblgenomes.org/id/AAC75430 EnsemblBacteria BAA16242 http://www.ensemblgenomes.org/id/BAA16242 EnsemblBacteria BAA16242 http://www.ensemblgenomes.org/id/BAA16242 EnsemblBacteria BAA16242 http://www.ensemblgenomes.org/id/BAA16242 EnsemblBacteria b2371 http://www.ensemblgenomes.org/id/b2371 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0036412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036412 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 Gene3D 3.40.50.10540 http://www.cathdb.info/version/latest/superfamily/3.40.50.10540 GeneID 946432 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946432 HOGENOM HOG000219745 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219745&db=HOGENOM6 InParanoid P76518 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76518 IntAct P76518 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76518* IntEnz 2.8.3.19 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.8.3.19 InterPro IPR003673 http://www.ebi.ac.uk/interpro/entry/IPR003673 InterPro IPR023606 http://www.ebi.ac.uk/interpro/entry/IPR023606 KEGG_Gene ecj:JW2368 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2368 KEGG_Gene eco:b2371 http://www.genome.jp/dbget-bin/www_bget?eco:b2371 MINT MINT-1289026 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1289026 OMA HCAVSGF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HCAVSGF PDB 4HL6 http://www.ebi.ac.uk/pdbe-srv/view/entry/4HL6 PDBsum 4HL6 http://www.ebi.ac.uk/pdbsum/4HL6 PSORT swissprot:ACOCT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ACOCT_ECOLI PSORT-B swissprot:ACOCT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ACOCT_ECOLI PSORT2 swissprot:ACOCT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ACOCT_ECOLI Pfam PF02515 http://pfam.xfam.org/family/PF02515 Phobius swissprot:ACOCT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ACOCT_ECOLI PhylomeDB P76518 http://phylomedb.org/?seqid=P76518 ProteinModelPortal P76518 http://www.proteinmodelportal.org/query/uniprot/P76518 PubMed 12694615 http://www.ncbi.nlm.nih.gov/pubmed/12694615 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 23335415 http://www.ncbi.nlm.nih.gov/pubmed/23335415 PubMed 23935849 http://www.ncbi.nlm.nih.gov/pubmed/23935849 PubMed 8125343 http://www.ncbi.nlm.nih.gov/pubmed/8125343 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416872 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416872 RefSeq WP_001296867 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001296867 SMR P76518 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76518 STRING 511145.b2371 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2371&targetmode=cogs SUPFAM SSF89796 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF89796 UniProtKB ACOCT_ECOLI http://www.uniprot.org/uniprot/ACOCT_ECOLI UniProtKB-AC P76518 http://www.uniprot.org/uniprot/P76518 charge swissprot:ACOCT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ACOCT_ECOLI eggNOG COG1804 http://eggnogapi.embl.de/nog_data/html/tree/COG1804 eggNOG ENOG4105C04 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C04 epestfind swissprot:ACOCT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ACOCT_ECOLI garnier swissprot:ACOCT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ACOCT_ECOLI helixturnhelix swissprot:ACOCT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ACOCT_ECOLI hmoment swissprot:ACOCT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ACOCT_ECOLI iep swissprot:ACOCT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ACOCT_ECOLI inforesidue swissprot:ACOCT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ACOCT_ECOLI octanol swissprot:ACOCT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ACOCT_ECOLI pepcoil swissprot:ACOCT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ACOCT_ECOLI pepdigest swissprot:ACOCT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ACOCT_ECOLI pepinfo swissprot:ACOCT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ACOCT_ECOLI pepnet swissprot:ACOCT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ACOCT_ECOLI pepstats swissprot:ACOCT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ACOCT_ECOLI pepwheel swissprot:ACOCT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ACOCT_ECOLI pepwindow swissprot:ACOCT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ACOCT_ECOLI sigcleave swissprot:ACOCT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ACOCT_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES UGPQ_ECOLI Kinetic parameters KM=0.22 mM for glycerophosphoethanolamine {ECO 0000269|PubMed 18083802}; KM=0.66 mM for glycerophosphoserine {ECO 0000269|PubMed 18083802}; KM=0.62 mM for glycerophosphoglycerol {ECO 0000269|PubMed 18083802}; KM=0.39 mM for glycerophosphoinositol {ECO 0000269|PubMed 18083802}; KM=2.0 mM for glycerophosphocholine {ECO 0000269|PubMed 18083802}; pH dependence Optimum pH is 7.5. {ECO 0000269|PubMed 18083802}; # BRENDA 3.1.4.46 2026 # BioGrid 4261665 10 # CATALYTIC ACTIVITY A glycerophosphodiester + H(2)O = an alcohol + sn-glycerol 3-phosphate. {ECO:0000269|PubMed 18083802}. # COFACTOR UGPQ_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 18083802}; Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000269|PubMed 18083802}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 18083802}; # EcoGene EG11050 ugpQ # FUNCTION UGPQ_ECOLI Glycerophosphoryl diester phosphodiesterase hydrolyzes deacylated phospholipids to G3P and the corresponding alcohols. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0008889 glycerophosphodiester phosphodiesterase activity; IDA:EcoCyc. # GO_function GO:0047389 glycerophosphocholine phosphodiesterase activity; IDA:EcoCyc. # GO_function GO:0047395 glycerophosphoinositol glycerophosphodiesterase activity; IDA:EcoCyc. # GO_process GO:0006071 glycerol metabolic process; IEA:UniProtKB-KW. # GO_process GO:0006629 lipid metabolic process; IEA:InterPro. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.190 -; 1. # INDUCTION Up-regulated by low levels of phosphate in the medium. {ECO:0000269|PubMed 18083802}. # IntAct P10908 10 # InterPro IPR004129 GlyceroP-diester-Pdiesterase # InterPro IPR017946 PLC-like_Pdiesterase_TIM-brl # InterPro IPR030395 GP_PDE_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00564 Glycerophospholipid metabolism # MISCELLANEOUS There are 2 isozymes of glycerophosphoryl diester phosphodiesterase in E.coli a periplasmic isozyme (GlpQ) and a cytosolic isozyme (UgpQ). # Organism UGPQ_ECOLI Escherichia coli (strain K12) # PANTHER PTHR23344 PTHR23344 # PATRIC 32122338 VBIEscCol129921_3546 # PIR JV0024 ESECGD # PROSITE PS51704 GP_PDE # Pfam PF03009 GDPD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UGPQ_ECOLI Glycerophosphoryl diester phosphodiesterase # RefSeq NP_417906 NC_000913.3 # RefSeq WP_000073623 NZ_LN832404.1 # SIMILARITY Belongs to the glycerophosphoryl diester phosphodiesterase family. {ECO 0000305}. # SIMILARITY Contains 1 GP-PDE domain. {ECO 0000305}. # SUBCELLULAR LOCATION UGPQ_ECOLI Cytoplasm {ECO 0000269|PubMed 18083802}. # SUPFAM SSF51695 SSF51695 # eggNOG COG0584 LUCA # eggNOG ENOG4107T6V Bacteria BLAST swissprot:UGPQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UGPQ_ECOLI BioCyc ECOL316407:JW3414-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3414-MONOMER BioCyc EcoCyc:GLYCPDIESTER-CYTO-MONOMER http://biocyc.org/getid?id=EcoCyc:GLYCPDIESTER-CYTO-MONOMER BioCyc MetaCyc:GLYCPDIESTER-CYTO-MONOMER http://biocyc.org/getid?id=MetaCyc:GLYCPDIESTER-CYTO-MONOMER COG COG0584 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0584 DOI 10.1007/BF00273621 http://dx.doi.org/10.1007/BF00273621 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/17.7.2854 http://dx.doi.org/10.1093/nar/17.7.2854 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1111/j.1365-2958.1988.tb00088.x http://dx.doi.org/10.1111/j.1365-2958.1988.tb00088.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01223-07 http://dx.doi.org/10.1128/JB.01223-07 EC_number EC:3.1.4.46 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.4.46 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X13141 http://www.ebi.ac.uk/ena/data/view/X13141 EMBL X14437 http://www.ebi.ac.uk/ena/data/view/X14437 EMBL X56908 http://www.ebi.ac.uk/ena/data/view/X56908 ENZYME 3.1.4.46 http://enzyme.expasy.org/EC/3.1.4.46 EchoBASE EB1043 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1043 EcoGene EG11050 http://www.ecogene.org/geneInfo.php?eg_id=EG11050 EnsemblBacteria AAC76474 http://www.ensemblgenomes.org/id/AAC76474 EnsemblBacteria AAC76474 http://www.ensemblgenomes.org/id/AAC76474 EnsemblBacteria BAE77844 http://www.ensemblgenomes.org/id/BAE77844 EnsemblBacteria BAE77844 http://www.ensemblgenomes.org/id/BAE77844 EnsemblBacteria BAE77844 http://www.ensemblgenomes.org/id/BAE77844 EnsemblBacteria b3449 http://www.ensemblgenomes.org/id/b3449 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0008889 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008889 GO_function GO:0047389 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047389 GO_function GO:0047395 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047395 GO_process GO:0006071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006071 GO_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.190 http://www.cathdb.info/version/latest/superfamily/3.20.20.190 GeneID 947955 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947955 HOGENOM HOG000004697 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000004697&db=HOGENOM6 InParanoid P10908 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P10908 IntAct P10908 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P10908* IntEnz 3.1.4.46 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.4.46 InterPro IPR004129 http://www.ebi.ac.uk/interpro/entry/IPR004129 InterPro IPR017946 http://www.ebi.ac.uk/interpro/entry/IPR017946 InterPro IPR030395 http://www.ebi.ac.uk/interpro/entry/IPR030395 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3414 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3414 KEGG_Gene eco:b3449 http://www.genome.jp/dbget-bin/www_bget?eco:b3449 KEGG_Orthology KO:K01126 http://www.genome.jp/dbget-bin/www_bget?KO:K01126 KEGG_Pathway ko00564 http://www.genome.jp/kegg-bin/show_pathway?ko00564 KEGG_Reaction rn:R01030 http://www.genome.jp/dbget-bin/www_bget?rn:R01030 KEGG_Reaction rn:R01470 http://www.genome.jp/dbget-bin/www_bget?rn:R01470 OMA CAQYGMA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CAQYGMA PANTHER PTHR23344 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23344 PROSITE PS51704 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51704 PSORT swissprot:UGPQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UGPQ_ECOLI PSORT-B swissprot:UGPQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UGPQ_ECOLI PSORT2 swissprot:UGPQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UGPQ_ECOLI Pfam PF03009 http://pfam.xfam.org/family/PF03009 Phobius swissprot:UGPQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UGPQ_ECOLI PhylomeDB P10908 http://phylomedb.org/?seqid=P10908 ProteinModelPortal P10908 http://www.proteinmodelportal.org/query/uniprot/P10908 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18083802 http://www.ncbi.nlm.nih.gov/pubmed/18083802 PubMed 1851953 http://www.ncbi.nlm.nih.gov/pubmed/1851953 PubMed 2541415 http://www.ncbi.nlm.nih.gov/pubmed/2541415 PubMed 3062310 http://www.ncbi.nlm.nih.gov/pubmed/3062310 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417906 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417906 RefSeq WP_000073623 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000073623 SMR P10908 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P10908 STRING 511145.b3449 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3449&targetmode=cogs STRING COG0584 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0584&targetmode=cogs SUPFAM SSF51695 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51695 UniProtKB UGPQ_ECOLI http://www.uniprot.org/uniprot/UGPQ_ECOLI UniProtKB-AC P10908 http://www.uniprot.org/uniprot/P10908 charge swissprot:UGPQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UGPQ_ECOLI eggNOG COG0584 http://eggnogapi.embl.de/nog_data/html/tree/COG0584 eggNOG ENOG4107T6V http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107T6V epestfind swissprot:UGPQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UGPQ_ECOLI garnier swissprot:UGPQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UGPQ_ECOLI helixturnhelix swissprot:UGPQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UGPQ_ECOLI hmoment swissprot:UGPQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UGPQ_ECOLI iep swissprot:UGPQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UGPQ_ECOLI inforesidue swissprot:UGPQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UGPQ_ECOLI octanol swissprot:UGPQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UGPQ_ECOLI pepcoil swissprot:UGPQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UGPQ_ECOLI pepdigest swissprot:UGPQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UGPQ_ECOLI pepinfo swissprot:UGPQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UGPQ_ECOLI pepnet swissprot:UGPQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UGPQ_ECOLI pepstats swissprot:UGPQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UGPQ_ECOLI pepwheel swissprot:UGPQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UGPQ_ECOLI pepwindow swissprot:UGPQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UGPQ_ECOLI sigcleave swissprot:UGPQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UGPQ_ECOLI ## Database ID URL or Descriptions # AltName REND_ECOLI Putative defective protein Ren from DLP12 prophage # BioGrid 4259367 51 # CAUTION Could be the product of a pseudogene. The original protein is truncated by an IS3C element. {ECO 0000305}. # EcoGene EG12351 renD # MISCELLANEOUS REND_ECOLI Encoded by the cryptic lambdoid prophage DLP12. # Organism REND_ECOLI Escherichia coli (strain K12) # PIR D64786 D64786 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Putative protein RenD {ECO 0000305} BLAST swissprot:REND_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:REND_ECOLI BioCyc ECOL316407:JW0530-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0530-MONOMER BioCyc EcoCyc:G6298-MONOMER http://biocyc.org/getid?id=EcoCyc:G6298-MONOMER DIP DIP-48094N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48094N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EcoGene EG12351 http://www.ecogene.org/geneInfo.php?eg_id=EG12351 EnsemblBacteria BAE76317 http://www.ensemblgenomes.org/id/BAE76317 EnsemblBacteria BAE76317 http://www.ensemblgenomes.org/id/BAE76317 EnsemblBacteria BAE76317 http://www.ensemblgenomes.org/id/BAE76317 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv HOGENOM HOG000119298 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000119298&db=HOGENOM6 KEGG_Gene ecj:JW0530 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0530 PSORT swissprot:REND_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:REND_ECOLI PSORT-B swissprot:REND_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:REND_ECOLI PSORT2 swissprot:REND_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:REND_ECOLI Phobius swissprot:REND_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:REND_ECOLI ProteinModelPortal P75718 http://www.proteinmodelportal.org/query/uniprot/P75718 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 STRING 316407.85674677 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85674677&targetmode=cogs UniProtKB REND_ECOLI http://www.uniprot.org/uniprot/REND_ECOLI UniProtKB-AC P75718 http://www.uniprot.org/uniprot/P75718 charge swissprot:REND_ECOLI http://rest.g-language.org/emboss/charge/swissprot:REND_ECOLI epestfind swissprot:REND_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:REND_ECOLI garnier swissprot:REND_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:REND_ECOLI helixturnhelix swissprot:REND_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:REND_ECOLI hmoment swissprot:REND_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:REND_ECOLI iep swissprot:REND_ECOLI http://rest.g-language.org/emboss/iep/swissprot:REND_ECOLI inforesidue swissprot:REND_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:REND_ECOLI octanol swissprot:REND_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:REND_ECOLI pepcoil swissprot:REND_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:REND_ECOLI pepdigest swissprot:REND_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:REND_ECOLI pepinfo swissprot:REND_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:REND_ECOLI pepnet swissprot:REND_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:REND_ECOLI pepstats swissprot:REND_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:REND_ECOLI pepwheel swissprot:REND_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:REND_ECOLI pepwindow swissprot:REND_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:REND_ECOLI sigcleave swissprot:REND_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:REND_ECOLI ## Database ID URL or Descriptions # BioGrid 4260127 13 # EcoGene EG12969 yciQ # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GOslim_component GO:0005886 plasma membrane # InterPro IPR018702 DUF2207_membrane # Organism YCIQ_ECOLI Escherichia coli (strain K12) # PATRIC 32117794 VBIEscCol129921_1317 # PIR G64874 G64874 # Pfam PF09972 DUF2207 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCIQ_ECOLI Uncharacterized protein YciQ # RefSeq NP_415784 NC_000913.3 # RefSeq WP_001326916 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB59988.1; Type=Frameshift; Positions=198; Evidence={ECO:0000305}; Sequence=AAB59989.1; Type=Frameshift; Positions=198; Evidence={ECO 0000305}; # eggNOG ENOG4105EG3 Bacteria # eggNOG ENOG410XNNF LUCA BLAST swissprot:YCIQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCIQ_ECOLI BioCyc ECOL316407:JW5197-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5197-MONOMER BioCyc EcoCyc:G6636-MONOMER http://biocyc.org/getid?id=EcoCyc:G6636-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18111 http://www.ebi.ac.uk/ena/data/view/U18111 EMBL U18111 http://www.ebi.ac.uk/ena/data/view/U18111 EchoBASE EB2797 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2797 EcoGene EG12969 http://www.ecogene.org/geneInfo.php?eg_id=EG12969 EnsemblBacteria AAC74350 http://www.ensemblgenomes.org/id/AAC74350 EnsemblBacteria AAC74350 http://www.ensemblgenomes.org/id/AAC74350 EnsemblBacteria BAA14803 http://www.ensemblgenomes.org/id/BAA14803 EnsemblBacteria BAA14803 http://www.ensemblgenomes.org/id/BAA14803 EnsemblBacteria BAA14803 http://www.ensemblgenomes.org/id/BAA14803 EnsemblBacteria b1268 http://www.ensemblgenomes.org/id/b1268 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 945850 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945850 HOGENOM HOG000120076 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120076&db=HOGENOM6 InterPro IPR018702 http://www.ebi.ac.uk/interpro/entry/IPR018702 KEGG_Gene ecj:JW5197 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5197 KEGG_Gene eco:b1268 http://www.genome.jp/dbget-bin/www_bget?eco:b1268 OMA AEKDRMN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AEKDRMN PSORT swissprot:YCIQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCIQ_ECOLI PSORT-B swissprot:YCIQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCIQ_ECOLI PSORT2 swissprot:YCIQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCIQ_ECOLI Pfam PF09972 http://pfam.xfam.org/family/PF09972 Phobius swissprot:YCIQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCIQ_ECOLI ProteinModelPortal P45848 http://www.proteinmodelportal.org/query/uniprot/P45848 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415784 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415784 RefSeq WP_001326916 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001326916 STRING 511145.b1268 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1268&targetmode=cogs UniProtKB YCIQ_ECOLI http://www.uniprot.org/uniprot/YCIQ_ECOLI UniProtKB-AC P45848 http://www.uniprot.org/uniprot/P45848 charge swissprot:YCIQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCIQ_ECOLI eggNOG ENOG4105EG3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EG3 eggNOG ENOG410XNNF http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNNF epestfind swissprot:YCIQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCIQ_ECOLI garnier swissprot:YCIQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCIQ_ECOLI helixturnhelix swissprot:YCIQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCIQ_ECOLI hmoment swissprot:YCIQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCIQ_ECOLI iep swissprot:YCIQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCIQ_ECOLI inforesidue swissprot:YCIQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCIQ_ECOLI octanol swissprot:YCIQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCIQ_ECOLI pepcoil swissprot:YCIQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCIQ_ECOLI pepdigest swissprot:YCIQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCIQ_ECOLI pepinfo swissprot:YCIQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCIQ_ECOLI pepnet swissprot:YCIQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCIQ_ECOLI pepstats swissprot:YCIQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCIQ_ECOLI pepwheel swissprot:YCIQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCIQ_ECOLI pepwindow swissprot:YCIQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCIQ_ECOLI sigcleave swissprot:YCIQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCIQ_ECOLI ## Database ID URL or Descriptions # AltName Bacteriophage Q beta RNA-directed RNA polymerase subunit III {ECO:0000303|PubMed 816798} # AltName EFTU2_ECOLI P-43 # BRENDA 3.6.5 2026 # CAUTION EF-Tu 1 and EF-Tu 2 differ in a single position and are no longer merged. However, many papers are found in both entries as it is not always possible to determine for each paper which of EF-Tu 1 or EF-Tu 2 was being worked upon. {ECO 0000305}. # CDD cd03697 EFTU_II # EcoGene EG11037 tufB # FUNCTION EFTU2_ECOLI In case of infection by bacteriophage Qbeta, part of the viral RNA-dependent RNA polymerase complex. With EF-Ts may provide a stabilizing scaffold for the beta (catalytic) subunit. Helps separate the double-stranded RNA of the template and growing RNA during elongation (PubMed 22245970). With the beta subunit helps form the exit tunnel for template RNA. The GTPase activity of this subunit is not required for viral RNA replication (PubMed 20798060). {ECO 0000269|PubMed 20534494, ECO 0000269|PubMed 20798060, ECO 0000269|PubMed 22245970, ECO 0000269|PubMed 22884418, ECO 0000269|PubMed 25122749, ECO 0000269|PubMed 816798}. # FUNCTION EFTU2_ECOLI May play an important regulatory role in cell growth and in the bacterial response to nutrient deprivation. # FUNCTION EFTU2_ECOLI Plays a stimulatory role in trans-translation, binds tmRNA. {ECO 0000269|PubMed 15069072}. # FUNCTION EFTU2_ECOLI This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_function GO:0003746 translation elongation factor activity; IBA:GO_Central. # GO_function GO:0003924 GTPase activity; IBA:GO_Central. # GO_function GO:0005525 GTP binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006414 translational elongation; IBA:GO_Central. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003924 GTPase activity # GOslim_function GO:0008135 translation factor activity, RNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.300 -; 1. # HAMAP MF_00118_B EF_Tu_B # InterPro IPR000795 TF_GTP-bd_dom # InterPro IPR004160 Transl_elong_EFTu/EF1A_C # InterPro IPR004161 EFTu-like_2 # InterPro IPR004541 Transl_elong_EFTu/EF1A_bac/org # InterPro IPR005225 Small_GTP-bd_dom # InterPro IPR009000 Transl_B-barrel # InterPro IPR009001 Transl_elong_EF1A/Init_IF2_C # InterPro IPR027417 P-loop_NTPase # InterPro IPR031157 G_TR_CS # InterPro IPR033720 EFTU_2 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko03012 Translation factors # KEGG_Pathway ko04626 Plant-pathogen interaction # MISCELLANEOUS EFTU2_ECOLI In order to produce high amounts of bacteriophage Qbeta RNA polymerase catalytic core, a fusion protein consisting of tsf-tufB-replicase with a cleavable linker between tufB and the viral replicase subunit is frequently used. {ECO 0000269|PubMed 16781472, ECO 0000269|PubMed 20798060, ECO 0000269|PubMed 22245970, ECO 0000269|PubMed 22884418, ECO 0000269|PubMed 25122749}. # MISCELLANEOUS Present with about 70,000 molecules/cell. {ECO:0000305|PubMed 775340}. # MISCELLANEOUS The antibiotic kirromycin inhibits protein biosynthesis by inhibiting the release of EF-Tu from the ribosome. TufA resistance to kirromycin is conferred by mutations to Gln- 125, Gly-317 and Ala-376. This has not been formally proven for tufB, but is certainly correct. {ECO 0000305}. # MISCELLANEOUS The antibiotic pulvomycin inhibits protein biosynthesis by disrupting the allosteric control mechanism of EF- Tu TufA resistance to pulvomycin is conferred by Arg-231, Arg-334 and Thr-335. This has not been formally proven for tufB, but is certainly correct. {ECO 0000305}. # Organism EFTU2_ECOLI Escherichia coli (strain K12) # PATRIC 32123481 VBIEscCol129921_4093 # PDB 1DG1 X-ray; 2.50 A; G/H=1-394 # PDB 1EFM X-ray; 2.70 A; A=2-394 # PDB 1EFU X-ray; 2.50 A; A/C=10-394 # PDB 1LS2 EM; 16.80 A; A=2-394 # PDB 1OB2 X-ray; 3.35 A; A=3-394 # PDB 1QZD EM; -; A=2-394 # PDB 2BVN X-ray; 2.30 A; A/B=2-394 # PDB 3AGP X-ray; 2.80 A; A=1-394 # PDB 3AGQ X-ray; 3.22 A; A=1-394 # PDB 3AVT X-ray; 2.61 A; A=1-394 # PDB 3AVU X-ray; 2.91 A; A=1-394 # PDB 3AVV X-ray; 3.12 A; A=1-394 # PDB 3AVW X-ray; 2.60 A; A=1-394 # PDB 3AVX X-ray; 2.41 A; A=1-394 # PDB 3AVY X-ray; 2.62 A; A=1-394 # PDB 3MMP X-ray; 2.50 A; A/C=1-394 # PDB 3VNU X-ray; 3.20 A; A=1-394 # PDB 3VNV X-ray; 2.60 A; A=1-394 # PDB 4FWT X-ray; 3.20 A; A=1-394 # PDB 4R71 X-ray; 3.21 A; A/C=1-394 # PDB 4V69 EM; 6.70 A; Z=2-394 # PDB 4V6K EM; 8.25 A; BC=2-394 # PDB 4V6L EM; 13.20 A; AC=2-394 # PDB 5AFI EM; 2.90 A; z=2-394 # PIR A91478 EFECT # PRINTS PR00315 ELONGATNFCT # PROSITE PS00301 G_TR_1 # PROSITE PS51722 G_TR_2 # PTM EFTU2_ECOLI Methylated in vivo on Lys-57 in response to nutrient starvation. {ECO 0000269|PubMed 2022614, ECO 0000269|PubMed 389663, ECO 0000269|PubMed 6997043, ECO 0000269|PubMed 7021545}. # PTM EFTU2_ECOLI Phosphorylated in vitro by HipA on Thr-383 (PubMed 19150849), this has since been reported not to occur in vivo (PubMed 24095282). {ECO 0000269|PubMed 19150849, ECO 0000269|PubMed 24095282, ECO 0000269|PubMed 24141193, ECO 0000269|PubMed 8416965}. # PTM EFTU2_ECOLI Phosphorylated in vitro by phage protein doc on Thr-383. {ECO 0000269|PubMed 19150849, ECO 0000269|PubMed 24141193, ECO 0000269|PubMed 8416965}. # PTM EFTU2_ECOLI The N-terminus is blocked. # Pfam PF03143 GTP_EFTU_D3 # Pfam PF03144 GTP_EFTU_D2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Elongation factor Tu 2 {ECO:0000255|HAMAP-Rule MF_00118} # RefSeq NP_418407 NC_000913.3 # RefSeq WP_000031784 NZ_LN832404.1 # SIMILARITY Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. {ECO:0000255|HAMAP-Rule MF_00118}. # SIMILARITY Contains 1 tr-type G (guanine nucleotide-binding) domain. {ECO 0000305}. # SUBCELLULAR LOCATION EFTU2_ECOLI Cytoplasm. Cell inner membrane; Peripheral membrane protein. Note=Between 50-80% of the protein is associated with the cell inner membrane. Localization to the membrane has been suggested to follow nutrient stress. # SUBUNIT EFTU2_ECOLI Monomer. In case of infection by bacteriophage Qbeta, part of the viral RNA-dependent RNA polymerase complex, the other subunits are the viral replicase catalytic subunit (AC P14647), host ribosomal protein S1 and EF-Ts (PubMed 816798). {ECO 0000255|HAMAP-Rule MF_00118, ECO 0000269|PubMed 20534494, ECO 0000269|PubMed 20798060, ECO 0000269|PubMed 22245970, ECO 0000269|PubMed 22884418, ECO 0000269|PubMed 25122749, ECO 0000269|PubMed 816798, ECO 0000269|PubMed 8596629, ECO 0000269|PubMed 8939740}. # SUPFAM SSF50447 SSF50447 # SUPFAM SSF50465 SSF50465 # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR00231 small_GTP # TIGRFAMs TIGR00485 EF-Tu # eggNOG COG0050 LUCA # eggNOG ENOG4105CGV Bacteria BLAST swissprot:EFTU2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EFTU2_ECOLI BioCyc EcoCyc:EG11037-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11037-MONOMER COG COG0050 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0050 DIP DIP-60620N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-60620N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1998.2387 http://dx.doi.org/10.1006/jmbi.1998.2387 DOI 10.1007/BF00270131 http://dx.doi.org/10.1007/BF00270131 DOI 10.1016/0003-9861(89)90452-9 http://dx.doi.org/10.1016/0003-9861(89)90452-9 DOI 10.1016/0014-5793(79)80407-X http://dx.doi.org/10.1016/0014-5793(79)80407-X DOI 10.1016/0022-2836(92)90986-T http://dx.doi.org/10.1016/0022-2836(92)90986-T DOI 10.1016/0378-1119(80)90013-X http://dx.doi.org/10.1016/0378-1119(80)90013-X DOI 10.1016/S0969-2126(96)00123-2 http://dx.doi.org/10.1016/S0969-2126(96)00123-2 DOI 10.1016/j.molcel.2013.08.045 http://dx.doi.org/10.1016/j.molcel.2013.08.045 DOI 10.1016/j.str.2012.07.004 http://dx.doi.org/10.1016/j.str.2012.07.004 DOI 10.1038/261023a0 http://dx.doi.org/10.1038/261023a0 DOI 10.1038/379511a0 http://dx.doi.org/10.1038/379511a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nchembio.1364 http://dx.doi.org/10.1038/nchembio.1364 DOI 10.1038/nchembio.495 http://dx.doi.org/10.1038/nchembio.495 DOI 10.1038/nsb1003 http://dx.doi.org/10.1038/nsb1003 DOI 10.1038/nsmb.2204 http://dx.doi.org/10.1038/nsmb.2204 DOI 10.1073/pnas.1003015107 http://dx.doi.org/10.1073/pnas.1003015107 DOI 10.1073/pnas.1006559107 http://dx.doi.org/10.1073/pnas.1006559107 DOI 10.1074/jbc.273.8.4556 http://dx.doi.org/10.1074/jbc.273.8.4556 DOI 10.1074/jbc.M314086200 http://dx.doi.org/10.1074/jbc.M314086200 DOI 10.1074/jbc.M505951200 http://dx.doi.org/10.1074/jbc.M505951200 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/emboj/cdf326 http://dx.doi.org/10.1093/emboj/cdf326 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1093/nar/gku745 http://dx.doi.org/10.1093/nar/gku745 DOI 10.1111/j.1432-1033.1980.tb04748.x http://dx.doi.org/10.1111/j.1432-1033.1980.tb04748.x DOI 10.1126/science.1163806 http://dx.doi.org/10.1126/science.1163806 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1126/science.3898365 http://dx.doi.org/10.1126/science.3898365 DOI 10.1263/jbb.101.421 http://dx.doi.org/10.1263/jbb.101.421 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01717 http://www.ebi.ac.uk/ena/data/view/J01717 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X57091 http://www.ebi.ac.uk/ena/data/view/X57091 EchoBASE EB1030 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1030 EcoGene EG11037 http://www.ecogene.org/geneInfo.php?eg_id=EG11037 EnsemblBacteria AAC76954 http://www.ensemblgenomes.org/id/AAC76954 EnsemblBacteria AAC76954 http://www.ensemblgenomes.org/id/AAC76954 EnsemblBacteria BAE77340 http://www.ensemblgenomes.org/id/BAE77340 EnsemblBacteria BAE77340 http://www.ensemblgenomes.org/id/BAE77340 EnsemblBacteria BAE77340 http://www.ensemblgenomes.org/id/BAE77340 EnsemblBacteria b3980 http://www.ensemblgenomes.org/id/b3980 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0003746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003746 GO_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_process GO:0006414 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006414 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GOslim_function GO:0008135 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008135 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948482 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948482 HAMAP MF_00118_B http://hamap.expasy.org/unirule/MF_00118_B InParanoid P0CE48 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CE48 InterPro IPR000795 http://www.ebi.ac.uk/interpro/entry/IPR000795 InterPro IPR004160 http://www.ebi.ac.uk/interpro/entry/IPR004160 InterPro IPR004161 http://www.ebi.ac.uk/interpro/entry/IPR004161 InterPro IPR004541 http://www.ebi.ac.uk/interpro/entry/IPR004541 InterPro IPR005225 http://www.ebi.ac.uk/interpro/entry/IPR005225 InterPro IPR009000 http://www.ebi.ac.uk/interpro/entry/IPR009000 InterPro IPR009001 http://www.ebi.ac.uk/interpro/entry/IPR009001 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR031157 http://www.ebi.ac.uk/interpro/entry/IPR031157 InterPro IPR033720 http://www.ebi.ac.uk/interpro/entry/IPR033720 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko03012 http://www.genome.jp/dbget-bin/www_bget?ko03012 KEGG_Gene ecj:JW3943 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3943 KEGG_Gene eco:b3980 http://www.genome.jp/dbget-bin/www_bget?eco:b3980 KEGG_Orthology KO:K02358 http://www.genome.jp/dbget-bin/www_bget?KO:K02358 KEGG_Pathway ko04626 http://www.genome.jp/kegg-bin/show_pathway?ko04626 MINT MINT-1234073 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1234073 OMA IEMFHKE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IEMFHKE PDB 1DG1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1DG1 PDB 1EFM http://www.ebi.ac.uk/pdbe-srv/view/entry/1EFM PDB 1EFU http://www.ebi.ac.uk/pdbe-srv/view/entry/1EFU PDB 1LS2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1LS2 PDB 1OB2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1OB2 PDB 1QZD http://www.ebi.ac.uk/pdbe-srv/view/entry/1QZD PDB 2BVN http://www.ebi.ac.uk/pdbe-srv/view/entry/2BVN PDB 3AGP http://www.ebi.ac.uk/pdbe-srv/view/entry/3AGP PDB 3AGQ http://www.ebi.ac.uk/pdbe-srv/view/entry/3AGQ PDB 3AVT http://www.ebi.ac.uk/pdbe-srv/view/entry/3AVT PDB 3AVU http://www.ebi.ac.uk/pdbe-srv/view/entry/3AVU PDB 3AVV http://www.ebi.ac.uk/pdbe-srv/view/entry/3AVV PDB 3AVW http://www.ebi.ac.uk/pdbe-srv/view/entry/3AVW PDB 3AVX http://www.ebi.ac.uk/pdbe-srv/view/entry/3AVX PDB 3AVY http://www.ebi.ac.uk/pdbe-srv/view/entry/3AVY PDB 3MMP http://www.ebi.ac.uk/pdbe-srv/view/entry/3MMP PDB 3VNU http://www.ebi.ac.uk/pdbe-srv/view/entry/3VNU PDB 3VNV http://www.ebi.ac.uk/pdbe-srv/view/entry/3VNV PDB 4FWT http://www.ebi.ac.uk/pdbe-srv/view/entry/4FWT PDB 4R71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4R71 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDBsum 1DG1 http://www.ebi.ac.uk/pdbsum/1DG1 PDBsum 1EFM http://www.ebi.ac.uk/pdbsum/1EFM PDBsum 1EFU http://www.ebi.ac.uk/pdbsum/1EFU PDBsum 1LS2 http://www.ebi.ac.uk/pdbsum/1LS2 PDBsum 1OB2 http://www.ebi.ac.uk/pdbsum/1OB2 PDBsum 1QZD http://www.ebi.ac.uk/pdbsum/1QZD PDBsum 2BVN http://www.ebi.ac.uk/pdbsum/2BVN PDBsum 3AGP http://www.ebi.ac.uk/pdbsum/3AGP PDBsum 3AGQ http://www.ebi.ac.uk/pdbsum/3AGQ PDBsum 3AVT http://www.ebi.ac.uk/pdbsum/3AVT PDBsum 3AVU http://www.ebi.ac.uk/pdbsum/3AVU PDBsum 3AVV http://www.ebi.ac.uk/pdbsum/3AVV PDBsum 3AVW http://www.ebi.ac.uk/pdbsum/3AVW PDBsum 3AVX http://www.ebi.ac.uk/pdbsum/3AVX PDBsum 3AVY http://www.ebi.ac.uk/pdbsum/3AVY PDBsum 3MMP http://www.ebi.ac.uk/pdbsum/3MMP PDBsum 3VNU http://www.ebi.ac.uk/pdbsum/3VNU PDBsum 3VNV http://www.ebi.ac.uk/pdbsum/3VNV PDBsum 4FWT http://www.ebi.ac.uk/pdbsum/4FWT PDBsum 4R71 http://www.ebi.ac.uk/pdbsum/4R71 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PRINTS PR00315 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00315 PROSITE PS00301 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00301 PROSITE PS51722 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51722 PSORT swissprot:EFTU2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EFTU2_ECOLI PSORT-B swissprot:EFTU2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EFTU2_ECOLI PSORT2 swissprot:EFTU2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EFTU2_ECOLI Pfam PF03143 http://pfam.xfam.org/family/PF03143 Pfam PF03144 http://pfam.xfam.org/family/PF03144 Phobius swissprot:EFTU2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EFTU2_ECOLI PhylomeDB P0CE48 http://phylomedb.org/?seqid=P0CE48 ProteinModelPortal P0CE48 http://www.proteinmodelportal.org/query/uniprot/P0CE48 PubMed 12093756 http://www.ncbi.nlm.nih.gov/pubmed/12093756 PubMed 14566331 http://www.ncbi.nlm.nih.gov/pubmed/14566331 PubMed 15069072 http://www.ncbi.nlm.nih.gov/pubmed/15069072 PubMed 1542116 http://www.ncbi.nlm.nih.gov/pubmed/1542116 PubMed 16257965 http://www.ncbi.nlm.nih.gov/pubmed/16257965 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16781472 http://www.ncbi.nlm.nih.gov/pubmed/16781472 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 19150849 http://www.ncbi.nlm.nih.gov/pubmed/19150849 PubMed 2022614 http://www.ncbi.nlm.nih.gov/pubmed/2022614 PubMed 20534494 http://www.ncbi.nlm.nih.gov/pubmed/20534494 PubMed 20798060 http://www.ncbi.nlm.nih.gov/pubmed/20798060 PubMed 21151122 http://www.ncbi.nlm.nih.gov/pubmed/21151122 PubMed 22245970 http://www.ncbi.nlm.nih.gov/pubmed/22245970 PubMed 22884418 http://www.ncbi.nlm.nih.gov/pubmed/22884418 PubMed 24095282 http://www.ncbi.nlm.nih.gov/pubmed/24095282 PubMed 24141193 http://www.ncbi.nlm.nih.gov/pubmed/24141193 PubMed 2498311 http://www.ncbi.nlm.nih.gov/pubmed/2498311 PubMed 2508560 http://www.ncbi.nlm.nih.gov/pubmed/2508560 PubMed 25122749 http://www.ncbi.nlm.nih.gov/pubmed/25122749 PubMed 3308869 http://www.ncbi.nlm.nih.gov/pubmed/3308869 PubMed 389663 http://www.ncbi.nlm.nih.gov/pubmed/389663 PubMed 3898365 http://www.ncbi.nlm.nih.gov/pubmed/3898365 PubMed 6997043 http://www.ncbi.nlm.nih.gov/pubmed/6997043 PubMed 7011904 http://www.ncbi.nlm.nih.gov/pubmed/7011904 PubMed 7021545 http://www.ncbi.nlm.nih.gov/pubmed/7021545 PubMed 7035813 http://www.ncbi.nlm.nih.gov/pubmed/7035813 PubMed 775340 http://www.ncbi.nlm.nih.gov/pubmed/775340 PubMed 816798 http://www.ncbi.nlm.nih.gov/pubmed/816798 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 8416965 http://www.ncbi.nlm.nih.gov/pubmed/8416965 PubMed 8596629 http://www.ncbi.nlm.nih.gov/pubmed/8596629 PubMed 8939740 http://www.ncbi.nlm.nih.gov/pubmed/8939740 PubMed 8978702 http://www.ncbi.nlm.nih.gov/pubmed/8978702 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9468511 http://www.ncbi.nlm.nih.gov/pubmed/9468511 PubMed 9918724 http://www.ncbi.nlm.nih.gov/pubmed/9918724 RefSeq NP_418407 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418407 RefSeq WP_000031784 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000031784 SMR P0CE48 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0CE48 STRING 511145.b3980 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3980&targetmode=cogs STRING COG0050 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0050&targetmode=cogs SUPFAM SSF50447 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50447 SUPFAM SSF50465 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50465 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR00231 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00231 TIGRFAMs TIGR00485 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00485 UniProtKB EFTU2_ECOLI http://www.uniprot.org/uniprot/EFTU2_ECOLI UniProtKB-AC P0CE48 http://www.uniprot.org/uniprot/P0CE48 charge swissprot:EFTU2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EFTU2_ECOLI eggNOG COG0050 http://eggnogapi.embl.de/nog_data/html/tree/COG0050 eggNOG ENOG4105CGV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CGV epestfind swissprot:EFTU2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EFTU2_ECOLI garnier swissprot:EFTU2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EFTU2_ECOLI helixturnhelix swissprot:EFTU2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EFTU2_ECOLI hmoment swissprot:EFTU2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EFTU2_ECOLI iep swissprot:EFTU2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EFTU2_ECOLI inforesidue swissprot:EFTU2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EFTU2_ECOLI octanol swissprot:EFTU2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EFTU2_ECOLI pepcoil swissprot:EFTU2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EFTU2_ECOLI pepdigest swissprot:EFTU2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EFTU2_ECOLI pepinfo swissprot:EFTU2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EFTU2_ECOLI pepnet swissprot:EFTU2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EFTU2_ECOLI pepstats swissprot:EFTU2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EFTU2_ECOLI pepwheel swissprot:EFTU2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EFTU2_ECOLI pepwindow swissprot:EFTU2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EFTU2_ECOLI sigcleave swissprot:EFTU2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EFTU2_ECOLI ## Database ID URL or Descriptions # BioGrid 4259208 6 # COFACTOR CSID_ECOLI Name=Fe cation; Xref=ChEBI CHEBI 24875; Evidence={ECO 0000269|PubMed 11910018}; Note=Binds 1 Fe cation per subunit. {ECO 0000269|PubMed 11910018}; # EcoGene EG13523 csiD # FUNCTION CSID_ECOLI May be involved in the control of utilization of gamma- aminobutyric acid. {ECO 0000305|PubMed 11910018}. # GO_function GO:0005506 iron ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0051289 protein homotetramerization; IDA:EcoCyc. # GO_process GO:0090549 response to carbon starvation; IEP:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0006950 response to stress # HAMAP MF_01083 CsiD # INDUCTION CSID_ECOLI Expression is induced by RpoS during carbon starvation and at stationary phase. Is also regulated by cAMP-CRP and Lrp, which play the roles of a nearly essential activator and of a positive modulator, respectively. Repressed by CsiR. {ECO 0000269|PubMed 14731280, ECO 0000269|PubMed 9512707}. # InterPro IPR015038 Uncharacterised_CsiD # Organism CSID_ECOLI Escherichia coli (strain K12) # PATRIC 32120708 VBIEscCol129921_2751 # PDB 1JR7 X-ray; 2.00 A; A=15-325 # PIR D65045 D65045 # Pfam PF08943 CsiD # ProDom PD135861 DUF_CsiD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Protein CsiD {ECO 0000305} # RefSeq NP_417145 NC_000913.3 # RefSeq WP_000993126 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAD10865.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the CsiD family. {ECO 0000305}. # SUBUNIT Homotetramer. {ECO:0000269|PubMed 11910018}. # eggNOG ENOG4105EK3 Bacteria # eggNOG ENOG410XQW4 LUCA BLAST swissprot:CSID_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CSID_ECOLI BioCyc ECOL316407:JW5427-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5427-MONOMER BioCyc EcoCyc:G7394-MONOMER http://biocyc.org/getid?id=EcoCyc:G7394-MONOMER DOI 10.1006/jmbi.1997.1533 http://dx.doi.org/10.1006/jmbi.1997.1533 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2003.03867.x http://dx.doi.org/10.1046/j.1365-2958.2003.03867.x DOI 10.1110/ps.4570102 http://dx.doi.org/10.1110/ps.4570102 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U68243 http://www.ebi.ac.uk/ena/data/view/U68243 EchoBASE EB3295 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3295 EcoGene EG13523 http://www.ecogene.org/geneInfo.php?eg_id=EG13523 EnsemblBacteria AAC75706 http://www.ensemblgenomes.org/id/AAC75706 EnsemblBacteria AAC75706 http://www.ensemblgenomes.org/id/AAC75706 EnsemblBacteria BAE76779 http://www.ensemblgenomes.org/id/BAE76779 EnsemblBacteria BAE76779 http://www.ensemblgenomes.org/id/BAE76779 EnsemblBacteria BAE76779 http://www.ensemblgenomes.org/id/BAE76779 EnsemblBacteria b2659 http://www.ensemblgenomes.org/id/b2659 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0051289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051289 GO_process GO:0090549 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090549 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 948076 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948076 HAMAP MF_01083 http://hamap.expasy.org/unirule/MF_01083 HOGENOM HOG000224333 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000224333&db=HOGENOM6 InterPro IPR015038 http://www.ebi.ac.uk/interpro/entry/IPR015038 KEGG_Gene ecj:JW5427 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5427 KEGG_Gene eco:b2659 http://www.genome.jp/dbget-bin/www_bget?eco:b2659 KEGG_Orthology KO:K15737 http://www.genome.jp/dbget-bin/www_bget?KO:K15737 OMA HNDGTFV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HNDGTFV PDB 1JR7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1JR7 PDBsum 1JR7 http://www.ebi.ac.uk/pdbsum/1JR7 PSORT swissprot:CSID_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CSID_ECOLI PSORT-B swissprot:CSID_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CSID_ECOLI PSORT2 swissprot:CSID_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CSID_ECOLI Pfam PF08943 http://pfam.xfam.org/family/PF08943 Phobius swissprot:CSID_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CSID_ECOLI ProteinModelPortal P76621 http://www.proteinmodelportal.org/query/uniprot/P76621 PubMed 11910018 http://www.ncbi.nlm.nih.gov/pubmed/11910018 PubMed 14731280 http://www.ncbi.nlm.nih.gov/pubmed/14731280 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9512707 http://www.ncbi.nlm.nih.gov/pubmed/9512707 RefSeq NP_417145 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417145 RefSeq WP_000993126 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000993126 SMR P76621 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76621 STRING 511145.b2659 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2659&targetmode=cogs UniProtKB CSID_ECOLI http://www.uniprot.org/uniprot/CSID_ECOLI UniProtKB-AC P76621 http://www.uniprot.org/uniprot/P76621 charge swissprot:CSID_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CSID_ECOLI eggNOG ENOG4105EK3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EK3 eggNOG ENOG410XQW4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQW4 epestfind swissprot:CSID_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CSID_ECOLI garnier swissprot:CSID_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CSID_ECOLI helixturnhelix swissprot:CSID_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CSID_ECOLI hmoment swissprot:CSID_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CSID_ECOLI iep swissprot:CSID_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CSID_ECOLI inforesidue swissprot:CSID_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CSID_ECOLI octanol swissprot:CSID_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CSID_ECOLI pepcoil swissprot:CSID_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CSID_ECOLI pepdigest swissprot:CSID_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CSID_ECOLI pepinfo swissprot:CSID_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CSID_ECOLI pepnet swissprot:CSID_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CSID_ECOLI pepstats swissprot:CSID_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CSID_ECOLI pepwheel swissprot:CSID_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CSID_ECOLI pepwindow swissprot:CSID_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CSID_ECOLI sigcleave swissprot:CSID_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CSID_ECOLI ## Database ID URL or Descriptions # BioGrid 4262385 13 # CAUTION GLGS_ECOLI Was originally thought to be involved in glycogen synthesis, but it was shown later that its effect on glycogen metabolism is probably indirect. {ECO 0000305|PubMed 1324388, ECO 0000305|PubMed 23537328}. # DISRUPTION PHENOTYPE Deletion mutants show increased flagella and fimbriae production, are hypermotile, and exhibit increased biofilm formation. {ECO:0000269|PubMed 23537328}. # EcoGene EG11381 glgS # FUNCTION GLGS_ECOLI Major determinant of cell surface composition. Negatively regulates motility, adhesion and synthesis of biofilm exopolysaccharides. {ECO 0000255|HAMAP-Rule MF_00525, ECO 0000269|PubMed 23537328}. # GO_process GO:0010676 positive regulation of cellular carbohydrate metabolic process; IMP:EcoCyc. # GO_process GO:1900232 negative regulation of single-species biofilm formation on inanimate substrate; IMP:EcoCyc. # GO_process GO:1902201 negative regulation of bacterial-type flagellum-dependent cell motility; IMP:EcoCyc. # GOslim_process GO:0008150 biological_process # Gene3D 1.20.970.20 -; 1. # HAMAP MF_00525 GlgS # INDUCTION Expression is dependent on RpoS. {ECO:0000269|PubMed 1324388}. # IntAct P26649 2 # InterPro IPR015065 GlgS # Organism GLGS_ECOLI Escherichia coli (strain K12) # PATRIC 32121510 VBIEscCol129921_3142 # PDB 1RRZ NMR; -; A=1-66 # PIR S25201 S25201 # Pfam PF08971 GlgS # ProDom PD054490 GlgS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLGS_ECOLI Surface composition regulator {ECO 0000255|HAMAP-Rule MF_00525, ECO 0000303|PubMed 23537328} # RefSeq NP_417521 NC_000913.3 # RefSeq WP_000350095 NZ_LN832404.1 # SIMILARITY Belongs to the GlgS family. {ECO:0000255|HAMAP- Rule MF_00525}. # SUPFAM SSF109747 SSF109747 # eggNOG ENOG4105WWV Bacteria # eggNOG ENOG411240A LUCA BLAST swissprot:GLGS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLGS_ECOLI BioCyc ECOL316407:JW3021-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3021-MONOMER BioCyc EcoCyc:EG11381-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11381-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/BJ20130154 http://dx.doi.org/10.1042/BJ20130154 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1365-2958.1992.tb01360.x http://dx.doi.org/10.1111/j.1365-2958.1992.tb01360.x DOI 10.1111/j.1432-1033.1997.t01-1-00301.x http://dx.doi.org/10.1111/j.1432-1033.1997.t01-1-00301.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL Z11885 http://www.ebi.ac.uk/ena/data/view/Z11885 EchoBASE EB1355 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1355 EcoGene EG11381 http://www.ecogene.org/geneInfo.php?eg_id=EG11381 EnsemblBacteria AAC76085 http://www.ensemblgenomes.org/id/AAC76085 EnsemblBacteria AAC76085 http://www.ensemblgenomes.org/id/AAC76085 EnsemblBacteria BAA16577 http://www.ensemblgenomes.org/id/BAA16577 EnsemblBacteria BAA16577 http://www.ensemblgenomes.org/id/BAA16577 EnsemblBacteria BAA16577 http://www.ensemblgenomes.org/id/BAA16577 EnsemblBacteria b3049 http://www.ensemblgenomes.org/id/b3049 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0010676 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010676 GO_process GO:1900232 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1900232 GO_process GO:1902201 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902201 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.20.970.20 http://www.cathdb.info/version/latest/superfamily/1.20.970.20 GeneID 947533 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947533 HAMAP MF_00525 http://hamap.expasy.org/unirule/MF_00525 HOGENOM HOG000004893 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000004893&db=HOGENOM6 IntAct P26649 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P26649* InterPro IPR015065 http://www.ebi.ac.uk/interpro/entry/IPR015065 KEGG_Gene ecj:JW3021 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3021 KEGG_Gene eco:b3049 http://www.genome.jp/dbget-bin/www_bget?eco:b3049 OMA HRSWFCK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HRSWFCK PDB 1RRZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1RRZ PDBsum 1RRZ http://www.ebi.ac.uk/pdbsum/1RRZ PSORT swissprot:GLGS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLGS_ECOLI PSORT-B swissprot:GLGS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLGS_ECOLI PSORT2 swissprot:GLGS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLGS_ECOLI Pfam PF08971 http://pfam.xfam.org/family/PF08971 Phobius swissprot:GLGS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLGS_ECOLI ProteinModelPortal P26649 http://www.proteinmodelportal.org/query/uniprot/P26649 PubMed 1324388 http://www.ncbi.nlm.nih.gov/pubmed/1324388 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 23537328 http://www.ncbi.nlm.nih.gov/pubmed/23537328 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9208918 http://www.ncbi.nlm.nih.gov/pubmed/9208918 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417521 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417521 RefSeq WP_000350095 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000350095 SMR P26649 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P26649 STRING 511145.b3049 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3049&targetmode=cogs SUPFAM SSF109747 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF109747 UniProtKB GLGS_ECOLI http://www.uniprot.org/uniprot/GLGS_ECOLI UniProtKB-AC P26649 http://www.uniprot.org/uniprot/P26649 charge swissprot:GLGS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLGS_ECOLI eggNOG ENOG4105WWV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105WWV eggNOG ENOG411240A http://eggnogapi.embl.de/nog_data/html/tree/ENOG411240A epestfind swissprot:GLGS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLGS_ECOLI garnier swissprot:GLGS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLGS_ECOLI helixturnhelix swissprot:GLGS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLGS_ECOLI hmoment swissprot:GLGS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLGS_ECOLI iep swissprot:GLGS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLGS_ECOLI inforesidue swissprot:GLGS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLGS_ECOLI octanol swissprot:GLGS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLGS_ECOLI pepcoil swissprot:GLGS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLGS_ECOLI pepdigest swissprot:GLGS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLGS_ECOLI pepinfo swissprot:GLGS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLGS_ECOLI pepnet swissprot:GLGS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLGS_ECOLI pepstats swissprot:GLGS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLGS_ECOLI pepwheel swissprot:GLGS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLGS_ECOLI pepwindow swissprot:GLGS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLGS_ECOLI sigcleave swissprot:GLGS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLGS_ECOLI ## Database ID URL or Descriptions # BioGrid 4260088 187 # EcoGene EG13440 lolD # FUNCTION LOLD_ECOLI Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and of LolA. # GO_component GO:0005886 plasma membrane; IDA:CACAO. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IEA:UniProtKB-HAMAP. # GO_component GO:0043234 protein complex; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0016887 ATPase activity; IEA:InterPro. # GO_function GO:0042954 lipoprotein transporter activity; IDA:EcoCyc. # GO_process GO:0042953 lipoprotein transport; IDA:EcoCyc. # GO_process GO:0044874 lipoprotein localization to outer membrane; IMP:CACAO. # GO_process GO:0089705 protein localization to outer membrane; IDA:CACAO. # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # GOslim_process GO:0061024 membrane organization # Gene3D 3.40.50.300 -; 1. # IntAct P75957 7 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR011924 LolD_lipo_ATP-bd # InterPro IPR015854 ABC_transpr_LolD # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00255 Lipoprotein-releasing system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism LOLD_ECOLI Escherichia coli (strain K12) # PATRIC 32117481 VBIEscCol129921_1163 # PIR B64856 B64856 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # PROSITE PS51244 LOLD # Pfam PF00005 ABC_tran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Lipoprotein-releasing system ATP-binding protein LolD {ECO:0000255|HAMAP-Rule MF_01708} # RefSeq NP_415635 NC_000913.3 # RefSeq WP_001033694 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family. {ECO:0000255|HAMAP- Rule MF_01708}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|HAMAP- Rule MF_01708}. # SMART SM00382 AAA # SUBCELLULAR LOCATION LOLD_ECOLI Cell inner membrane; Peripheral membrane protein. # SUBUNIT LOLD_ECOLI The complex is composed of two ATP-binding proteins (LolD) and two transmembrane proteins (LolC and LolE). {ECO 0000255|HAMAP-Rule MF_01708, ECO 0000269|PubMed 11844772}. # SUPFAM SSF52540 SSF52540 # TCDB 3.A.1.125 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR02211 LolD_lipo_ex # eggNOG COG1136 LUCA # eggNOG ENOG4105CQU Bacteria BLAST swissprot:LOLD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LOLD_ECOLI BioCyc ECOL316407:JW5162-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5162-MONOMER BioCyc EcoCyc:YCFV-MONOMER http://biocyc.org/getid?id=EcoCyc:YCFV-MONOMER COG COG1136 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1136 DIP DIP-10115N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10115N DOI 10.1038/35008635 http://dx.doi.org/10.1038/35008635 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.5.1417-1422.2002 http://dx.doi.org/10.1128/JB.184.5.1417-1422.2002 EC_number EC:3.6.3.- {ECO:0000255|HAMAP-Rule:MF_01708} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.- {ECO:0000255|HAMAP-Rule:MF_01708} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.6.3.- {ECO:0000255|HAMAP-Rule:MF_01708} http://enzyme.expasy.org/EC/3.6.3.- {ECO:0000255|HAMAP-Rule:MF_01708} EchoBASE EB3214 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3214 EcoGene EG13440 http://www.ecogene.org/geneInfo.php?eg_id=EG13440 EnsemblBacteria AAC74201 http://www.ensemblgenomes.org/id/AAC74201 EnsemblBacteria AAC74201 http://www.ensemblgenomes.org/id/AAC74201 EnsemblBacteria BAA35937 http://www.ensemblgenomes.org/id/BAA35937 EnsemblBacteria BAA35937 http://www.ensemblgenomes.org/id/BAA35937 EnsemblBacteria BAA35937 http://www.ensemblgenomes.org/id/BAA35937 EnsemblBacteria b1117 http://www.ensemblgenomes.org/id/b1117 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_function GO:0042954 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042954 GO_process GO:0042953 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042953 GO_process GO:0044874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044874 GO_process GO:0089705 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0089705 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0061024 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945670 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945670 InParanoid P75957 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75957 IntAct P75957 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75957* IntEnz 3.6.3.- {ECO:0000255|HAMAP-Rule:MF_01708} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.- {ECO:0000255|HAMAP-Rule:MF_01708} InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR011924 http://www.ebi.ac.uk/interpro/entry/IPR011924 InterPro IPR015854 http://www.ebi.ac.uk/interpro/entry/IPR015854 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5162 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5162 KEGG_Gene eco:b1117 http://www.genome.jp/dbget-bin/www_bget?eco:b1117 KEGG_Orthology KO:K09810 http://www.genome.jp/dbget-bin/www_bget?KO:K09810 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA AMQPGEM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AMQPGEM PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PROSITE PS51244 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51244 PSORT swissprot:LOLD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LOLD_ECOLI PSORT-B swissprot:LOLD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LOLD_ECOLI PSORT2 swissprot:LOLD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LOLD_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Phobius swissprot:LOLD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LOLD_ECOLI PhylomeDB P75957 http://phylomedb.org/?seqid=P75957 ProteinModelPortal P75957 http://www.proteinmodelportal.org/query/uniprot/P75957 PubMed 10783239 http://www.ncbi.nlm.nih.gov/pubmed/10783239 PubMed 11844772 http://www.ncbi.nlm.nih.gov/pubmed/11844772 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415635 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415635 RefSeq WP_001033694 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001033694 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P75957 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75957 STRING 511145.b1117 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1117&targetmode=cogs STRING COG1136 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1136&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.125 http://www.tcdb.org/search/result.php?tc=3.A.1.125 TIGRFAMs TIGR02211 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02211 UniProtKB LOLD_ECOLI http://www.uniprot.org/uniprot/LOLD_ECOLI UniProtKB-AC P75957 http://www.uniprot.org/uniprot/P75957 charge swissprot:LOLD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LOLD_ECOLI eggNOG COG1136 http://eggnogapi.embl.de/nog_data/html/tree/COG1136 eggNOG ENOG4105CQU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CQU epestfind swissprot:LOLD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LOLD_ECOLI garnier swissprot:LOLD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LOLD_ECOLI helixturnhelix swissprot:LOLD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LOLD_ECOLI hmoment swissprot:LOLD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LOLD_ECOLI iep swissprot:LOLD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LOLD_ECOLI inforesidue swissprot:LOLD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LOLD_ECOLI octanol swissprot:LOLD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LOLD_ECOLI pepcoil swissprot:LOLD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LOLD_ECOLI pepdigest swissprot:LOLD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LOLD_ECOLI pepinfo swissprot:LOLD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LOLD_ECOLI pepnet swissprot:LOLD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LOLD_ECOLI pepstats swissprot:LOLD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LOLD_ECOLI pepwheel swissprot:LOLD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LOLD_ECOLI pepwindow swissprot:LOLD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LOLD_ECOLI sigcleave swissprot:LOLD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LOLD_ECOLI ## Database ID URL or Descriptions # AltName FOCA_ECOLI Formate channel 1 # BioGrid 4260836 3 # EcoGene EG11258 focA # FUNCTION FOCA_ECOLI Involved in the bidirectional transport of formate. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_function GO:0015499 formate transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0015724 formate transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # Gene3D 1.20.1080.10 -; 1. # InterPro IPR000292 For/NO2_transpt # InterPro IPR023271 Aquaporin-like # InterPro IPR023999 Formate_transptr_FocA_put # InterPro IPR024002 For/NO2_transpt_CS # KEGG_Brite ko02000 Transporters # Organism FOCA_ECOLI Escherichia coli (strain K12) # PATRIC 32117021 VBIEscCol129921_0935 # PIR A32305 A32305 # PROSITE PS01005 FORMATE_NITRITE_TP_1 # PROSITE PS01006 FORMATE_NITRITE_TP_2 # Pfam PF01226 Form_Nir_trans # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FOCA_ECOLI Probable formate transporter 1 # RefSeq NP_415424 NC_000913.3 # RefSeq WP_000642546 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA20390.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the FNT transporter (TC 2.A.44) family. {ECO 0000305}. # SUBCELLULAR LOCATION FOCA_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # TCDB 1.A.16.1 the formate-nitrite transporter (fnt) family # TIGRFAMs TIGR00790 fnt # TIGRFAMs TIGR04060 formate_focA # eggNOG COG2116 LUCA # eggNOG ENOG4105TMB Bacteria BLAST swissprot:FOCA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FOCA_ECOLI BioCyc ECOL316407:JW0887-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0887-MONOMER BioCyc EcoCyc:FOCA-MONOMER http://biocyc.org/getid?id=EcoCyc:FOCA-MONOMER BioCyc MetaCyc:FOCA-MONOMER http://biocyc.org/getid?id=MetaCyc:FOCA-MONOMER COG COG2116 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2116 DIP DIP-9670N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9670N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1994.tb00375.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb00375.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M26413 http://www.ebi.ac.uk/ena/data/view/M26413 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1238 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1238 EcoGene EG11258 http://www.ecogene.org/geneInfo.php?eg_id=EG11258 EnsemblBacteria AAC73990 http://www.ensemblgenomes.org/id/AAC73990 EnsemblBacteria AAC73990 http://www.ensemblgenomes.org/id/AAC73990 EnsemblBacteria BAA35639 http://www.ensemblgenomes.org/id/BAA35639 EnsemblBacteria BAA35639 http://www.ensemblgenomes.org/id/BAA35639 EnsemblBacteria BAA35639 http://www.ensemblgenomes.org/id/BAA35639 EnsemblBacteria b0904 http://www.ensemblgenomes.org/id/b0904 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015499 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015499 GO_process GO:0015724 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015724 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 1.20.1080.10 http://www.cathdb.info/version/latest/superfamily/1.20.1080.10 GeneID 945513 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945513 HOGENOM HOG000271393 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000271393&db=HOGENOM6 InParanoid P0AC23 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AC23 IntAct P0AC23 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AC23* InterPro IPR000292 http://www.ebi.ac.uk/interpro/entry/IPR000292 InterPro IPR023271 http://www.ebi.ac.uk/interpro/entry/IPR023271 InterPro IPR023999 http://www.ebi.ac.uk/interpro/entry/IPR023999 InterPro IPR024002 http://www.ebi.ac.uk/interpro/entry/IPR024002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0887 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0887 KEGG_Gene eco:b0904 http://www.genome.jp/dbget-bin/www_bget?eco:b0904 KEGG_Orthology KO:K06212 http://www.genome.jp/dbget-bin/www_bget?KO:K06212 MINT MINT-1274847 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1274847 OMA KGIGCNW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KGIGCNW PROSITE PS01005 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01005 PROSITE PS01006 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01006 PSORT swissprot:FOCA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FOCA_ECOLI PSORT-B swissprot:FOCA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FOCA_ECOLI PSORT2 swissprot:FOCA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FOCA_ECOLI Pfam PF01226 http://pfam.xfam.org/family/PF01226 Phobius swissprot:FOCA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FOCA_ECOLI PhylomeDB P0AC23 http://phylomedb.org/?seqid=P0AC23 ProteinModelPortal P0AC23 http://www.proteinmodelportal.org/query/uniprot/P0AC23 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2651404 http://www.ncbi.nlm.nih.gov/pubmed/2651404 PubMed 8022272 http://www.ncbi.nlm.nih.gov/pubmed/8022272 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415424 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415424 RefSeq WP_000642546 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000642546 SMR P0AC23 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AC23 STRING 511145.b0904 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0904&targetmode=cogs STRING COG2116 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2116&targetmode=cogs TCDB 1.A.16.1 http://www.tcdb.org/search/result.php?tc=1.A.16.1 TIGRFAMs TIGR00790 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00790 TIGRFAMs TIGR04060 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR04060 UniProtKB FOCA_ECOLI http://www.uniprot.org/uniprot/FOCA_ECOLI UniProtKB-AC P0AC23 http://www.uniprot.org/uniprot/P0AC23 charge swissprot:FOCA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FOCA_ECOLI eggNOG COG2116 http://eggnogapi.embl.de/nog_data/html/tree/COG2116 eggNOG ENOG4105TMB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105TMB epestfind swissprot:FOCA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FOCA_ECOLI garnier swissprot:FOCA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FOCA_ECOLI helixturnhelix swissprot:FOCA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FOCA_ECOLI hmoment swissprot:FOCA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FOCA_ECOLI iep swissprot:FOCA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FOCA_ECOLI inforesidue swissprot:FOCA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FOCA_ECOLI octanol swissprot:FOCA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FOCA_ECOLI pepcoil swissprot:FOCA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FOCA_ECOLI pepdigest swissprot:FOCA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FOCA_ECOLI pepinfo swissprot:FOCA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FOCA_ECOLI pepnet swissprot:FOCA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FOCA_ECOLI pepstats swissprot:FOCA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FOCA_ECOLI pepwheel swissprot:FOCA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FOCA_ECOLI pepwindow swissprot:FOCA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FOCA_ECOLI sigcleave swissprot:FOCA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FOCA_ECOLI ## Database ID URL or Descriptions # AltName SYK1_ECOLI Lysyl-tRNA synthetase # BRENDA 6.1.1 2026 # BioGrid 4262337 587 # CATALYTIC ACTIVITY SYK1_ECOLI ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys). # CDD cd00775 LysRS_core # COFACTOR SYK1_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250}; Note=Binds 3 Mg(2+) ions per subunit. {ECO 0000250}; # EcoGene EG10552 lysS # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0003676 nucleic acid binding; IEA:InterPro. # GO_function GO:0004824 lysine-tRNA ligase activity; IGI:EcoliWiki. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0016874 ligase activity; IDA:EcoliWiki. # GO_process GO:0006418 tRNA aminoacylation for protein translation; IGI:EcoliWiki. # GO_process GO:0006430 lysyl-tRNA aminoacylation; IGI:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0006520 cellular amino acid metabolic process # HAMAP MF_00252 Lys_tRNA_synth_class2 # IntAct P0A8N3 24 # InterPro IPR002313 Lys-tRNA-ligase_II # InterPro IPR004364 aa-tRNA-synt_II # InterPro IPR004365 NA-bd_OB_tRNA # InterPro IPR006195 aa-tRNA-synth_II # InterPro IPR012340 NA-bd_OB-fold # InterPro IPR018149 Lys-tRNA-synth_II_C # InterPro IPR018150 aa-tRNA-synt_II-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01007 Amino acid related enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # KEGG_Pathway ko00970 Aminoacyl-tRNA biosynthesis # MISCELLANEOUS There are two lysyl-tRNA ligases in E.coli lysS is expressed constitutively, while lysU is heat inducible. # Organism SYK1_ECOLI Escherichia coli (strain K12) # PANTHER PTHR22594 PTHR22594 # PATRIC 32121190 VBIEscCol129921_2983 # PDB 1BBU X-ray; 2.70 A; A=2-505 # PDB 1BBW X-ray; 2.70 A; A=2-505 # PDB 1KRS NMR; -; A=31-149 # PDB 1KRT NMR; -; A=31-149 # PIR B65073 SYECKT # PIRSF PIRSF039101 LysRS2 # PRINTS PR00982 TRNASYNTHLYS # PROSITE PS50862 AA_TRNA_LIGASE_II # Pfam PF00152 tRNA-synt_2 # Pfam PF01336 tRNA_anti-codon # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SYK1_ECOLI Lysine--tRNA ligase # RefSeq NP_417366 NC_000913.3 # RefSeq WP_000003071 NZ_LN832404.1 # SIMILARITY Belongs to the class-II aminoacyl-tRNA synthetase family. {ECO 0000305}. # SUBCELLULAR LOCATION SYK1_ECOLI Cytoplasm. # SUBUNIT SYK1_ECOLI Homodimer. # SUPFAM SSF50249 SSF50249 # TIGRFAMs TIGR00499 lysS_bact # eggNOG COG1190 LUCA # eggNOG ENOG4105CRK Bacteria BLAST swissprot:SYK1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SYK1_ECOLI BioCyc ECOL316407:JW2858-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2858-MONOMER BioCyc EcoCyc:LYSS-MONOMER http://biocyc.org/getid?id=EcoCyc:LYSS-MONOMER BioCyc MetaCyc:LYSS-MONOMER http://biocyc.org/getid?id=MetaCyc:LYSS-MONOMER COG COG1190 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1190 DIP DIP-36211N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36211N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/jmbi.1995.0539 http://dx.doi.org/10.1006/jmbi.1995.0539 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.85.15.5620 http://dx.doi.org/10.1073/pnas.85.15.5620 DOI 10.1093/nar/18.2.305 http://dx.doi.org/10.1093/nar/18.2.305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.1.1.6 http://www.genome.jp/dbget-bin/www_bget?EC:6.1.1.6 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J03795 http://www.ebi.ac.uk/ena/data/view/J03795 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 ENZYME 6.1.1.6 http://enzyme.expasy.org/EC/6.1.1.6 EchoBASE EB0547 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0547 EcoGene EG10552 http://www.ecogene.org/geneInfo.php?eg_id=EG10552 EnsemblBacteria AAC75928 http://www.ensemblgenomes.org/id/AAC75928 EnsemblBacteria AAC75928 http://www.ensemblgenomes.org/id/AAC75928 EnsemblBacteria BAE76955 http://www.ensemblgenomes.org/id/BAE76955 EnsemblBacteria BAE76955 http://www.ensemblgenomes.org/id/BAE76955 EnsemblBacteria BAE76955 http://www.ensemblgenomes.org/id/BAE76955 EnsemblBacteria b2890 http://www.ensemblgenomes.org/id/b2890 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0003676 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003676 GO_function GO:0004824 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004824 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GO_process GO:0006418 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006418 GO_process GO:0006430 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006430 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GeneID 947372 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947372 HAMAP MF_00252 http://hamap.expasy.org/unirule/MF_00252 HOGENOM HOG000236578 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000236578&db=HOGENOM6 InParanoid P0A8N3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8N3 IntAct P0A8N3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8N3* IntEnz 6.1.1.6 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.1.1.6 InterPro IPR002313 http://www.ebi.ac.uk/interpro/entry/IPR002313 InterPro IPR004364 http://www.ebi.ac.uk/interpro/entry/IPR004364 InterPro IPR004365 http://www.ebi.ac.uk/interpro/entry/IPR004365 InterPro IPR006195 http://www.ebi.ac.uk/interpro/entry/IPR006195 InterPro IPR012340 http://www.ebi.ac.uk/interpro/entry/IPR012340 InterPro IPR018149 http://www.ebi.ac.uk/interpro/entry/IPR018149 InterPro IPR018150 http://www.ebi.ac.uk/interpro/entry/IPR018150 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW2858 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2858 KEGG_Gene eco:b2890 http://www.genome.jp/dbget-bin/www_bget?eco:b2890 KEGG_Orthology KO:K04567 http://www.genome.jp/dbget-bin/www_bget?KO:K04567 KEGG_Pathway ko00970 http://www.genome.jp/kegg-bin/show_pathway?ko00970 KEGG_Reaction rn:R03658 http://www.genome.jp/dbget-bin/www_bget?rn:R03658 MINT MINT-1227180 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1227180 OMA RYELYIG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RYELYIG PANTHER PTHR22594 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22594 PDB 1BBU http://www.ebi.ac.uk/pdbe-srv/view/entry/1BBU PDB 1BBW http://www.ebi.ac.uk/pdbe-srv/view/entry/1BBW PDB 1KRS http://www.ebi.ac.uk/pdbe-srv/view/entry/1KRS PDB 1KRT http://www.ebi.ac.uk/pdbe-srv/view/entry/1KRT PDBsum 1BBU http://www.ebi.ac.uk/pdbsum/1BBU PDBsum 1BBW http://www.ebi.ac.uk/pdbsum/1BBW PDBsum 1KRS http://www.ebi.ac.uk/pdbsum/1KRS PDBsum 1KRT http://www.ebi.ac.uk/pdbsum/1KRT PRINTS PR00982 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00982 PROSITE PS50862 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50862 PSORT swissprot:SYK1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SYK1_ECOLI PSORT-B swissprot:SYK1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SYK1_ECOLI PSORT2 swissprot:SYK1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SYK1_ECOLI Pfam PF00152 http://pfam.xfam.org/family/PF00152 Pfam PF01336 http://pfam.xfam.org/family/PF01336 Phobius swissprot:SYK1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SYK1_ECOLI PhylomeDB P0A8N3 http://phylomedb.org/?seqid=P0A8N3 ProteinModelPortal P0A8N3 http://www.proteinmodelportal.org/query/uniprot/P0A8N3 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2183178 http://www.ncbi.nlm.nih.gov/pubmed/2183178 PubMed 2456575 http://www.ncbi.nlm.nih.gov/pubmed/2456575 PubMed 7473706 http://www.ncbi.nlm.nih.gov/pubmed/7473706 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417366 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417366 RefSeq WP_000003071 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000003071 SMR P0A8N3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8N3 STRING 511145.b2890 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2890&targetmode=cogs STRING COG1190 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1190&targetmode=cogs SUPFAM SSF50249 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50249 SWISS-2DPAGE P0A8N3 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A8N3 TIGRFAMs TIGR00499 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00499 UniProtKB SYK1_ECOLI http://www.uniprot.org/uniprot/SYK1_ECOLI UniProtKB-AC P0A8N3 http://www.uniprot.org/uniprot/P0A8N3 charge swissprot:SYK1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SYK1_ECOLI eggNOG COG1190 http://eggnogapi.embl.de/nog_data/html/tree/COG1190 eggNOG ENOG4105CRK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CRK epestfind swissprot:SYK1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SYK1_ECOLI garnier swissprot:SYK1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SYK1_ECOLI helixturnhelix swissprot:SYK1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SYK1_ECOLI hmoment swissprot:SYK1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SYK1_ECOLI iep swissprot:SYK1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SYK1_ECOLI inforesidue swissprot:SYK1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SYK1_ECOLI octanol swissprot:SYK1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SYK1_ECOLI pepcoil swissprot:SYK1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SYK1_ECOLI pepdigest swissprot:SYK1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SYK1_ECOLI pepinfo swissprot:SYK1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SYK1_ECOLI pepnet swissprot:SYK1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SYK1_ECOLI pepstats swissprot:SYK1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SYK1_ECOLI pepwheel swissprot:SYK1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SYK1_ECOLI pepwindow swissprot:SYK1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SYK1_ECOLI sigcleave swissprot:SYK1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SYK1_ECOLI ## Database ID URL or Descriptions # BioGrid 4262782 8 # EcoGene EG10145 creD # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR010364 Uncharacterised_IM_CreD # MISCELLANEOUS CRED_ECOLI Mutations of this gene leads to an enhanced transcription of the gene cause tolerance to colicin E2. # Organism CRED_ECOLI Escherichia coli (strain K12) # PATRIC 32124418 VBIEscCol129921_4549 # PIR D25038 BVECCT # PIRSF PIRSF004548 CreD # Pfam PF06123 CreD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CRED_ECOLI Inner membrane protein CreD # RefSeq NP_418817 NC_000913.3 # RefSeq WP_000920294 NZ_LN832404.1 # SUBCELLULAR LOCATION CRED_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG COG4452 LUCA # eggNOG ENOG4105CT7 Bacteria BLAST swissprot:CRED_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CRED_ECOLI BioCyc ECOL316407:JW4363-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4363-MONOMER BioCyc EcoCyc:EG10145-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10145-MONOMER COG COG4452 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4452 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1111/j.1365-2958.1988.tb00012.x http://dx.doi.org/10.1111/j.1365-2958.1988.tb00012.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M13608 http://www.ebi.ac.uk/ena/data/view/M13608 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL Y00538 http://www.ebi.ac.uk/ena/data/view/Y00538 EchoBASE EB0143 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0143 EcoGene EG10145 http://www.ecogene.org/geneInfo.php?eg_id=EG10145 EnsemblBacteria AAC77353 http://www.ensemblgenomes.org/id/AAC77353 EnsemblBacteria AAC77353 http://www.ensemblgenomes.org/id/AAC77353 EnsemblBacteria BAE78389 http://www.ensemblgenomes.org/id/BAE78389 EnsemblBacteria BAE78389 http://www.ensemblgenomes.org/id/BAE78389 EnsemblBacteria BAE78389 http://www.ensemblgenomes.org/id/BAE78389 EnsemblBacteria b4400 http://www.ensemblgenomes.org/id/b4400 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 948868 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948868 HOGENOM HOG000211010 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000211010&db=HOGENOM6 InParanoid P08369 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P08369 InterPro IPR010364 http://www.ebi.ac.uk/interpro/entry/IPR010364 KEGG_Gene ecj:JW4363 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4363 KEGG_Gene eco:b4400 http://www.genome.jp/dbget-bin/www_bget?eco:b4400 KEGG_Orthology KO:K06143 http://www.genome.jp/dbget-bin/www_bget?KO:K06143 OMA PIQYALV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PIQYALV PSORT swissprot:CRED_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CRED_ECOLI PSORT-B swissprot:CRED_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CRED_ECOLI PSORT2 swissprot:CRED_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CRED_ECOLI Pfam PF06123 http://pfam.xfam.org/family/PF06123 Phobius swissprot:CRED_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CRED_ECOLI PhylomeDB P08369 http://phylomedb.org/?seqid=P08369 ProteinModelPortal P08369 http://www.proteinmodelportal.org/query/uniprot/P08369 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2835585 http://www.ncbi.nlm.nih.gov/pubmed/2835585 PubMed 2984198 http://www.ncbi.nlm.nih.gov/pubmed/2984198 PubMed 3531171 http://www.ncbi.nlm.nih.gov/pubmed/3531171 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418817 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418817 RefSeq WP_000920294 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000920294 SMR P08369 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P08369 STRING 511145.b4400 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4400&targetmode=cogs STRING COG4452 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4452&targetmode=cogs UniProtKB CRED_ECOLI http://www.uniprot.org/uniprot/CRED_ECOLI UniProtKB-AC P08369 http://www.uniprot.org/uniprot/P08369 charge swissprot:CRED_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CRED_ECOLI eggNOG COG4452 http://eggnogapi.embl.de/nog_data/html/tree/COG4452 eggNOG ENOG4105CT7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CT7 epestfind swissprot:CRED_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CRED_ECOLI garnier swissprot:CRED_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CRED_ECOLI helixturnhelix swissprot:CRED_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CRED_ECOLI hmoment swissprot:CRED_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CRED_ECOLI iep swissprot:CRED_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CRED_ECOLI inforesidue swissprot:CRED_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CRED_ECOLI octanol swissprot:CRED_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CRED_ECOLI pepcoil swissprot:CRED_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CRED_ECOLI pepdigest swissprot:CRED_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CRED_ECOLI pepinfo swissprot:CRED_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CRED_ECOLI pepnet swissprot:CRED_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CRED_ECOLI pepstats swissprot:CRED_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CRED_ECOLI pepwheel swissprot:CRED_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CRED_ECOLI pepwindow swissprot:CRED_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CRED_ECOLI sigcleave swissprot:CRED_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CRED_ECOLI ## Database ID URL or Descriptions # BioGrid 4259265 163 # EcoGene EG12721 ygjJ # Organism YGJJ_ECOLI Escherichia coli (strain K12) # PATRIC 32121574 VBIEscCol129921_3173 # PIR D65096 D65096 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGJJ_ECOLI Uncharacterized protein YgjJ # RefSeq NP_417550 NC_000913.3 # RefSeq WP_000767652 NZ_LN832404.1 # eggNOG ENOG4107W6W Bacteria # eggNOG ENOG410ZFY9 LUCA BLAST swissprot:YGJJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGJJ_ECOLI BioCyc ECOL316407:JW3050-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3050-MONOMER BioCyc EcoCyc:G7598-MONOMER http://biocyc.org/getid?id=EcoCyc:G7598-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2580 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2580 EcoGene EG12721 http://www.ecogene.org/geneInfo.php?eg_id=EG12721 EnsemblBacteria AAC76114 http://www.ensemblgenomes.org/id/AAC76114 EnsemblBacteria AAC76114 http://www.ensemblgenomes.org/id/AAC76114 EnsemblBacteria BAE77129 http://www.ensemblgenomes.org/id/BAE77129 EnsemblBacteria BAE77129 http://www.ensemblgenomes.org/id/BAE77129 EnsemblBacteria BAE77129 http://www.ensemblgenomes.org/id/BAE77129 EnsemblBacteria b3079 http://www.ensemblgenomes.org/id/b3079 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947597 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947597 HOGENOM HOG000125126 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125126&db=HOGENOM6 KEGG_Gene ecj:JW3050 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3050 KEGG_Gene eco:b3079 http://www.genome.jp/dbget-bin/www_bget?eco:b3079 OMA VFLMQYF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VFLMQYF PSORT swissprot:YGJJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGJJ_ECOLI PSORT-B swissprot:YGJJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGJJ_ECOLI PSORT2 swissprot:YGJJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGJJ_ECOLI Phobius swissprot:YGJJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGJJ_ECOLI ProteinModelPortal P42591 http://www.proteinmodelportal.org/query/uniprot/P42591 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417550 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417550 RefSeq WP_000767652 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000767652 STRING 511145.b3079 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3079&targetmode=cogs UniProtKB YGJJ_ECOLI http://www.uniprot.org/uniprot/YGJJ_ECOLI UniProtKB-AC P42591 http://www.uniprot.org/uniprot/P42591 charge swissprot:YGJJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGJJ_ECOLI eggNOG ENOG4107W6W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107W6W eggNOG ENOG410ZFY9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZFY9 epestfind swissprot:YGJJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGJJ_ECOLI garnier swissprot:YGJJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGJJ_ECOLI helixturnhelix swissprot:YGJJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGJJ_ECOLI hmoment swissprot:YGJJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGJJ_ECOLI iep swissprot:YGJJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGJJ_ECOLI inforesidue swissprot:YGJJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGJJ_ECOLI octanol swissprot:YGJJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGJJ_ECOLI pepcoil swissprot:YGJJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGJJ_ECOLI pepdigest swissprot:YGJJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGJJ_ECOLI pepinfo swissprot:YGJJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGJJ_ECOLI pepnet swissprot:YGJJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGJJ_ECOLI pepstats swissprot:YGJJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGJJ_ECOLI pepwheel swissprot:YGJJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGJJ_ECOLI pepwindow swissprot:YGJJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGJJ_ECOLI sigcleave swissprot:YGJJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGJJ_ECOLI ## Database ID URL or Descriptions # AltName LOLA_ECOLI P20 # BioGrid 4260649 271 # EcoGene EG12684 lolA # FUNCTION LOLA_ECOLI May act as a regulator of the RCS-phosphorelay signal transduction pathway. {ECO 0000269|PubMed 11758943}. # FUNCTION LOLA_ECOLI Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane); the inner membrane retention signal functions at the release step. {ECO 0000269|PubMed 11758943}. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0008565 protein transporter activity; IEA:UniProtKB-HAMAP. # GO_function GO:0042954 lipoprotein transporter activity; IDA:EcoCyc. # GO_process GO:0042953 lipoprotein transport; IDA:EcoCyc. # GO_process GO:0044874 lipoprotein localization to outer membrane; IDA:CACAO. # GO_process GO:0072323 chaperone-mediated protein transport across periplasmic space; IDA:CACAO. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008565 protein transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # HAMAP MF_00240 LolA # IntAct P61316 11 # InterPro IPR004564 OM_lipoprot_carrier_LolA-like # InterPro IPR018323 OM_lipoprot_carrier_LolA_Pbac # InterPro IPR029046 LolA/LolB/LppX # Organism LOLA_ECOLI Escherichia coli (strain K12) # PATRIC 32116993 VBIEscCol129921_0921 # PDB 1IWL X-ray; 1.65 A; A=22-203 # PDB 1UA8 X-ray; 1.90 A; A=22-203 # PDB 2ZPC X-ray; 2.35 A; A=22-203 # PDB 2ZPD X-ray; 1.85 A; A=22-203 # PDB 3KSN X-ray; 1.65 A; A=22-203 # PIR S57828 S57828 # Pfam PF03548 LolA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LOLA_ECOLI Outer-membrane lipoprotein carrier protein # RefSeq NP_415411 NC_000913.3 # RefSeq WP_001295343 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA08390.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA35616.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the LolA family. {ECO 0000305}. # SUBCELLULAR LOCATION LOLA_ECOLI Periplasm. # SUBUNIT LOLA_ECOLI Monomer. # SUPFAM SSF89392 SSF89392 # TCDB 1.B.46.1 the outer membrane lolab lipoprotein insertion apparatus (lolab) family # TIGRFAMs TIGR00547 lolA # eggNOG COG2834 LUCA # eggNOG ENOG4107Y7W Bacteria BLAST swissprot:LOLA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LOLA_ECOLI BioCyc ECOL316407:JW0874-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0874-MONOMER BioCyc EcoCyc:G6465-MONOMER http://biocyc.org/getid?id=EcoCyc:G6465-MONOMER COG COG2834 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2834 DIP DIP-35675N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35675N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/bbrc.2001.5705 http://dx.doi.org/10.1006/bbrc.2001.5705 DOI 10.1016/S0014-5793(02)03305-7 http://dx.doi.org/10.1016/S0014-5793(02)03305-7 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.112085599 http://dx.doi.org/10.1073/pnas.112085599 DOI 10.1074/jbc.M109307200 http://dx.doi.org/10.1074/jbc.M109307200 DOI 10.1074/jbc.M206816200 http://dx.doi.org/10.1074/jbc.M206816200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/emboj/cdg324 http://dx.doi.org/10.1093/emboj/cdg324 DOI 10.1107/S090744490301254X http://dx.doi.org/10.1107/S090744490301254X DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1271/bbb.65.2364 http://dx.doi.org/10.1271/bbb.65.2364 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D49398 http://www.ebi.ac.uk/ena/data/view/D49398 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2548 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2548 EcoGene EG12684 http://www.ecogene.org/geneInfo.php?eg_id=EG12684 EnsemblBacteria AAC73977 http://www.ensemblgenomes.org/id/AAC73977 EnsemblBacteria AAC73977 http://www.ensemblgenomes.org/id/AAC73977 EnsemblBacteria BAA35616 http://www.ensemblgenomes.org/id/BAA35616 EnsemblBacteria BAA35616 http://www.ensemblgenomes.org/id/BAA35616 EnsemblBacteria BAA35616 http://www.ensemblgenomes.org/id/BAA35616 EnsemblBacteria b0891 http://www.ensemblgenomes.org/id/b0891 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GO_function GO:0042954 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042954 GO_process GO:0042953 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042953 GO_process GO:0044874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044874 GO_process GO:0072323 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072323 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 948989 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948989 HAMAP MF_00240 http://hamap.expasy.org/unirule/MF_00240 HOGENOM HOG000257501 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000257501&db=HOGENOM6 InParanoid P61316 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P61316 IntAct P61316 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P61316* InterPro IPR004564 http://www.ebi.ac.uk/interpro/entry/IPR004564 InterPro IPR018323 http://www.ebi.ac.uk/interpro/entry/IPR018323 InterPro IPR029046 http://www.ebi.ac.uk/interpro/entry/IPR029046 KEGG_Gene ecj:JW0874 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0874 KEGG_Gene eco:b0891 http://www.genome.jp/dbget-bin/www_bget?eco:b0891 KEGG_Orthology KO:K03634 http://www.genome.jp/dbget-bin/www_bget?KO:K03634 MINT MINT-1249033 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1249033 OMA YDPFVEQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YDPFVEQ PDB 1IWL http://www.ebi.ac.uk/pdbe-srv/view/entry/1IWL PDB 1UA8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1UA8 PDB 2ZPC http://www.ebi.ac.uk/pdbe-srv/view/entry/2ZPC PDB 2ZPD http://www.ebi.ac.uk/pdbe-srv/view/entry/2ZPD PDB 3KSN http://www.ebi.ac.uk/pdbe-srv/view/entry/3KSN PDBsum 1IWL http://www.ebi.ac.uk/pdbsum/1IWL PDBsum 1UA8 http://www.ebi.ac.uk/pdbsum/1UA8 PDBsum 2ZPC http://www.ebi.ac.uk/pdbsum/2ZPC PDBsum 2ZPD http://www.ebi.ac.uk/pdbsum/2ZPD PDBsum 3KSN http://www.ebi.ac.uk/pdbsum/3KSN PSORT swissprot:LOLA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LOLA_ECOLI PSORT-B swissprot:LOLA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LOLA_ECOLI PSORT2 swissprot:LOLA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LOLA_ECOLI Pfam PF03548 http://pfam.xfam.org/family/PF03548 Phobius swissprot:LOLA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LOLA_ECOLI PhylomeDB P61316 http://phylomedb.org/?seqid=P61316 ProteinModelPortal P61316 http://www.proteinmodelportal.org/query/uniprot/P61316 PubMed 11587539 http://www.ncbi.nlm.nih.gov/pubmed/11587539 PubMed 11592971 http://www.ncbi.nlm.nih.gov/pubmed/11592971 PubMed 11758943 http://www.ncbi.nlm.nih.gov/pubmed/11758943 PubMed 12032293 http://www.ncbi.nlm.nih.gov/pubmed/12032293 PubMed 12198129 http://www.ncbi.nlm.nih.gov/pubmed/12198129 PubMed 12297303 http://www.ncbi.nlm.nih.gov/pubmed/12297303 PubMed 12839983 http://www.ncbi.nlm.nih.gov/pubmed/12839983 PubMed 12876347 http://www.ncbi.nlm.nih.gov/pubmed/12876347 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7628437 http://www.ncbi.nlm.nih.gov/pubmed/7628437 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_415411 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415411 RefSeq WP_001295343 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295343 SMR P61316 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P61316 STRING 511145.b0891 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0891&targetmode=cogs STRING COG2834 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2834&targetmode=cogs SUPFAM SSF89392 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF89392 SWISS-2DPAGE P61316 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P61316 TCDB 1.B.46.1 http://www.tcdb.org/search/result.php?tc=1.B.46.1 TIGRFAMs TIGR00547 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00547 UniProtKB LOLA_ECOLI http://www.uniprot.org/uniprot/LOLA_ECOLI UniProtKB-AC P61316 http://www.uniprot.org/uniprot/P61316 charge swissprot:LOLA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LOLA_ECOLI eggNOG COG2834 http://eggnogapi.embl.de/nog_data/html/tree/COG2834 eggNOG ENOG4107Y7W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107Y7W epestfind swissprot:LOLA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LOLA_ECOLI garnier swissprot:LOLA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LOLA_ECOLI helixturnhelix swissprot:LOLA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LOLA_ECOLI hmoment swissprot:LOLA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LOLA_ECOLI iep swissprot:LOLA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LOLA_ECOLI inforesidue swissprot:LOLA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LOLA_ECOLI octanol swissprot:LOLA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LOLA_ECOLI pepcoil swissprot:LOLA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LOLA_ECOLI pepdigest swissprot:LOLA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LOLA_ECOLI pepinfo swissprot:LOLA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LOLA_ECOLI pepnet swissprot:LOLA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LOLA_ECOLI pepstats swissprot:LOLA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LOLA_ECOLI pepwheel swissprot:LOLA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LOLA_ECOLI pepwindow swissprot:LOLA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LOLA_ECOLI sigcleave swissprot:LOLA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LOLA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260328 10 # EcoGene EG13501 yeaO # IntAct P76243 10 # InterPro IPR007438 DUF488 # Organism YEAO_ECOLI Escherichia coli (strain K12) # PATRIC 32118897 VBIEscCol129921_1866 # PIR H64939 H64939 # Pfam PF04343 DUF488 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEAO_ECOLI Uncharacterized protein YeaO # RefSeq NP_416306 NC_000913.3 # RefSeq WP_001326526 NZ_LN832404.1 # SIMILARITY To M.tuberculosis Rv3073c. {ECO 0000305}. # eggNOG COG3189 LUCA # eggNOG ENOG4105K78 Bacteria BLAST swissprot:YEAO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEAO_ECOLI BioCyc ECOL316407:JW1781-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1781-MONOMER BioCyc EcoCyc:G6978-MONOMER http://biocyc.org/getid?id=EcoCyc:G6978-MONOMER DIP DIP-11794N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11794N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3274 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3274 EcoGene EG13501 http://www.ecogene.org/geneInfo.php?eg_id=EG13501 EnsemblBacteria AAC74862 http://www.ensemblgenomes.org/id/AAC74862 EnsemblBacteria AAC74862 http://www.ensemblgenomes.org/id/AAC74862 EnsemblBacteria BAE76529 http://www.ensemblgenomes.org/id/BAE76529 EnsemblBacteria BAE76529 http://www.ensemblgenomes.org/id/BAE76529 EnsemblBacteria BAE76529 http://www.ensemblgenomes.org/id/BAE76529 EnsemblBacteria b1792 http://www.ensemblgenomes.org/id/b1792 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945675 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945675 HOGENOM HOG000017981 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000017981&db=HOGENOM6 InParanoid P76243 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76243 IntAct P76243 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76243* InterPro IPR007438 http://www.ebi.ac.uk/interpro/entry/IPR007438 KEGG_Gene ecj:JW1781 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1781 KEGG_Gene eco:b1792 http://www.genome.jp/dbget-bin/www_bget?eco:b1792 OMA RRWFGHD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RRWFGHD PSORT swissprot:YEAO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEAO_ECOLI PSORT-B swissprot:YEAO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEAO_ECOLI PSORT2 swissprot:YEAO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEAO_ECOLI Pfam PF04343 http://pfam.xfam.org/family/PF04343 Phobius swissprot:YEAO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEAO_ECOLI PhylomeDB P76243 http://phylomedb.org/?seqid=P76243 ProteinModelPortal P76243 http://www.proteinmodelportal.org/query/uniprot/P76243 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416306 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416306 RefSeq WP_001326526 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001326526 STRING 511145.b1792 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1792&targetmode=cogs UniProtKB YEAO_ECOLI http://www.uniprot.org/uniprot/YEAO_ECOLI UniProtKB-AC P76243 http://www.uniprot.org/uniprot/P76243 charge swissprot:YEAO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEAO_ECOLI eggNOG COG3189 http://eggnogapi.embl.de/nog_data/html/tree/COG3189 eggNOG ENOG4105K78 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K78 epestfind swissprot:YEAO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEAO_ECOLI garnier swissprot:YEAO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEAO_ECOLI helixturnhelix swissprot:YEAO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEAO_ECOLI hmoment swissprot:YEAO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEAO_ECOLI iep swissprot:YEAO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEAO_ECOLI inforesidue swissprot:YEAO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEAO_ECOLI octanol swissprot:YEAO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEAO_ECOLI pepcoil swissprot:YEAO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEAO_ECOLI pepdigest swissprot:YEAO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEAO_ECOLI pepinfo swissprot:YEAO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEAO_ECOLI pepnet swissprot:YEAO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEAO_ECOLI pepstats swissprot:YEAO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEAO_ECOLI pepwheel swissprot:YEAO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEAO_ECOLI pepwindow swissprot:YEAO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEAO_ECOLI sigcleave swissprot:YEAO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEAO_ECOLI ## Database ID URL or Descriptions # BioGrid 4262024 17 # EcoGene EG12742 yqjC # InterPro IPR009468 DUF1090 # Organism YQJC_ECOLI Escherichia coli (strain K12) # PATRIC 32121614 VBIEscCol129921_3193 # Pfam PF06476 DUF1090 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQJC_ECOLI Protein YqjC # RefSeq NP_417568 NC_000913.3 # RefSeq WP_001295543 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA57901.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # eggNOG ENOG4105WAY Bacteria # eggNOG ENOG41121W5 LUCA BLAST swissprot:YQJC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQJC_ECOLI BioCyc ECOL316407:JW5516-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5516-MONOMER BioCyc EcoCyc:G7611-MONOMER http://biocyc.org/getid?id=EcoCyc:G7611-MONOMER DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2598 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2598 EcoGene EG12742 http://www.ecogene.org/geneInfo.php?eg_id=EG12742 EnsemblBacteria AAC76132 http://www.ensemblgenomes.org/id/AAC76132 EnsemblBacteria AAC76132 http://www.ensemblgenomes.org/id/AAC76132 EnsemblBacteria BAE77147 http://www.ensemblgenomes.org/id/BAE77147 EnsemblBacteria BAE77147 http://www.ensemblgenomes.org/id/BAE77147 EnsemblBacteria BAE77147 http://www.ensemblgenomes.org/id/BAE77147 EnsemblBacteria b3097 http://www.ensemblgenomes.org/id/b3097 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947622 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947622 HOGENOM HOG000281845 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000281845&db=HOGENOM6 InParanoid P42616 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P42616 InterPro IPR009468 http://www.ebi.ac.uk/interpro/entry/IPR009468 KEGG_Gene ecj:JW5516 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5516 KEGG_Gene eco:b3097 http://www.genome.jp/dbget-bin/www_bget?eco:b3097 OMA SEVKANC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SEVKANC PSORT swissprot:YQJC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQJC_ECOLI PSORT-B swissprot:YQJC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQJC_ECOLI PSORT2 swissprot:YQJC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQJC_ECOLI Pfam PF06476 http://pfam.xfam.org/family/PF06476 Phobius swissprot:YQJC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQJC_ECOLI PhylomeDB P42616 http://phylomedb.org/?seqid=P42616 ProteinModelPortal P42616 http://www.proteinmodelportal.org/query/uniprot/P42616 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417568 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417568 RefSeq WP_001295543 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295543 STRING 511145.b3097 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3097&targetmode=cogs UniProtKB YQJC_ECOLI http://www.uniprot.org/uniprot/YQJC_ECOLI UniProtKB-AC P42616 http://www.uniprot.org/uniprot/P42616 charge swissprot:YQJC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQJC_ECOLI eggNOG ENOG4105WAY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105WAY eggNOG ENOG41121W5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41121W5 epestfind swissprot:YQJC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQJC_ECOLI garnier swissprot:YQJC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQJC_ECOLI helixturnhelix swissprot:YQJC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQJC_ECOLI hmoment swissprot:YQJC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQJC_ECOLI iep swissprot:YQJC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQJC_ECOLI inforesidue swissprot:YQJC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQJC_ECOLI octanol swissprot:YQJC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQJC_ECOLI pepcoil swissprot:YQJC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQJC_ECOLI pepdigest swissprot:YQJC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQJC_ECOLI pepinfo swissprot:YQJC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQJC_ECOLI pepnet swissprot:YQJC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQJC_ECOLI pepstats swissprot:YQJC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQJC_ECOLI pepwheel swissprot:YQJC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQJC_ECOLI pepwindow swissprot:YQJC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQJC_ECOLI sigcleave swissprot:YQJC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQJC_ECOLI ## Database ID URL or Descriptions # AltName ASTC_ECOLI Carbon starvation protein C # AltName ASTC_ECOLI Succinylornithine aminotransferase # BioGrid 4263005 11 # CATALYTIC ACTIVITY ASTC_ECOLI N(2)-succinyl-L-ornithine + 2-oxoglutarate = N-succinyl-L-glutamate 5-semialdehyde + L-glutamate. # CDD cd00610 OAT_like # COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI 597326; # EcoGene EG13999 argM # FUNCTION ASTC_ECOLI Catalyzes the transamination of N(2)-succinylornithine and alpha-ketoglutarate into N(2)-succinylglutamate semialdehyde and glutamate. Can also act as an acetylornithine aminotransferase. {ECO 0000269|PubMed 9696779}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function ASTC_ECOLI GO 0003992 N2-acetyl-L-ornithine 2-oxoglutarate 5-aminotransferase activity; IDA EcoCyc. # GO_function GO:0030170 pyridoxal phosphate binding; IBA:GO_Central. # GO_function GO:0042802 identical protein binding; IBA:GO_Central. # GO_function GO:0043825 succinylornithine transaminase activity; IDA:EcoliWiki. # GO_process GO:0006527 arginine catabolic process; IMP:EcoliWiki. # GO_process GO:0006593 ornithine catabolic process; IMP:EcoliWiki. # GO_process GO:0019544 arginine catabolic process to glutamate; IEA:UniProtKB-HAMAP. # GO_process GO:0019545 arginine catabolic process to succinate; IMP:EcoCyc. # GO_process GO:0042450 arginine biosynthetic process via ornithine; IGI:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.640.10 -; 1. # Gene3D 3.90.1150.10 -; 2. # HAMAP MF_01107 ArgD_aminotrans_3 # HAMAP MF_01173 AstC_aminotrans_3 # IntAct P77581 2 # InterPro IPR004636 AcOrn/SuccOrn_fam # InterPro IPR005814 Aminotrans_3 # InterPro IPR015421 PyrdxlP-dep_Trfase_major_sub1 # InterPro IPR015422 PyrdxlP-dep_Trfase_major_sub2 # InterPro IPR015424 PyrdxlP-dep_Trfase # InterPro IPR017652 Ac/SucOrn_transaminase_bac # InterPro IPR026330 SOAT # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01007 Amino acid related enzymes # KEGG_Pathway ko00330 Arginine and proline metabolism # Organism ASTC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11986 PTHR11986 # PATHWAY Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine step 3/5. # PATRIC 32118805 VBIEscCol129921_1820 # PDB 4ADB X-ray; 2.20 A; A/B/C/D=1-406 # PDB 4ADC X-ray; 2.30 A; A/B/C/D=1-406 # PDB 4ADD X-ray; 2.45 A; A/B/C/D=1-406 # PDB 4ADE X-ray; 2.75 A; A/B=1-406 # PIR D64934 D64934 # PROSITE PS00600 AA_TRANSFER_CLASS_3 # Pfam PF00202 Aminotran_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ASTC_ECOLI Succinylornithine transaminase # RefSeq NP_416262 NC_000913.3 # RefSeq WP_000081983 NZ_LN832404.1 # SIMILARITY Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. AstC subfamily. {ECO 0000305}. # SUPFAM SSF53383 SSF53383 # TIGRFAMs TIGR00707 argD # TIGRFAMs TIGR03246 arg_catab_astC # UniPathway UPA00185 UER00281 # eggNOG COG4992 LUCA # eggNOG ENOG4105C8Y Bacteria BLAST swissprot:ASTC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ASTC_ECOLI BioCyc ECOL316407:JW1737-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1737-MONOMER BioCyc EcoCyc:SUCCORNTRANSAM-MONOMER http://biocyc.org/getid?id=EcoCyc:SUCCORNTRANSAM-MONOMER BioCyc MetaCyc:SUCCORNTRANSAM-MONOMER http://biocyc.org/getid?id=MetaCyc:SUCCORNTRANSAM-MONOMER COG COG0160 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0160 DIP DIP-9145N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9145N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.6.1.81 http://www.genome.jp/dbget-bin/www_bget?EC:2.6.1.81 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U90416 http://www.ebi.ac.uk/ena/data/view/U90416 ENZYME 2.6.1.81 http://enzyme.expasy.org/EC/2.6.1.81 EchoBASE EB3755 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3755 EcoGene EG13999 http://www.ecogene.org/geneInfo.php?eg_id=EG13999 EnsemblBacteria AAC74818 http://www.ensemblgenomes.org/id/AAC74818 EnsemblBacteria AAC74818 http://www.ensemblgenomes.org/id/AAC74818 EnsemblBacteria BAA15539 http://www.ensemblgenomes.org/id/BAA15539 EnsemblBacteria BAA15539 http://www.ensemblgenomes.org/id/BAA15539 EnsemblBacteria BAA15539 http://www.ensemblgenomes.org/id/BAA15539 EnsemblBacteria b1748 http://www.ensemblgenomes.org/id/b1748 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003992 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003992 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0043825 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043825 GO_process GO:0006527 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006527 GO_process GO:0006593 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006593 GO_process GO:0019544 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019544 GO_process GO:0019545 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019545 GO_process GO:0042450 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042450 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.640.10 http://www.cathdb.info/version/latest/superfamily/3.40.640.10 Gene3D 3.90.1150.10 http://www.cathdb.info/version/latest/superfamily/3.90.1150.10 GeneID 946255 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946255 HAMAP MF_01107 http://hamap.expasy.org/unirule/MF_01107 HAMAP MF_01173 http://hamap.expasy.org/unirule/MF_01173 HOGENOM HOG000020206 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000020206&db=HOGENOM6 InParanoid P77581 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77581 IntAct P77581 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77581* IntEnz 2.6.1.81 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.6.1.81 InterPro IPR004636 http://www.ebi.ac.uk/interpro/entry/IPR004636 InterPro IPR005814 http://www.ebi.ac.uk/interpro/entry/IPR005814 InterPro IPR015421 http://www.ebi.ac.uk/interpro/entry/IPR015421 InterPro IPR015422 http://www.ebi.ac.uk/interpro/entry/IPR015422 InterPro IPR015424 http://www.ebi.ac.uk/interpro/entry/IPR015424 InterPro IPR017652 http://www.ebi.ac.uk/interpro/entry/IPR017652 InterPro IPR026330 http://www.ebi.ac.uk/interpro/entry/IPR026330 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Gene ecj:JW1737 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1737 KEGG_Gene eco:b1748 http://www.genome.jp/dbget-bin/www_bget?eco:b1748 KEGG_Orthology KO:K00840 http://www.genome.jp/dbget-bin/www_bget?KO:K00840 KEGG_Pathway ko00330 http://www.genome.jp/kegg-bin/show_pathway?ko00330 KEGG_Reaction rn:R04217 http://www.genome.jp/dbget-bin/www_bget?rn:R04217 OMA MPPCDFI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MPPCDFI PANTHER PTHR11986 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11986 PDB 4ADB http://www.ebi.ac.uk/pdbe-srv/view/entry/4ADB PDB 4ADC http://www.ebi.ac.uk/pdbe-srv/view/entry/4ADC PDB 4ADD http://www.ebi.ac.uk/pdbe-srv/view/entry/4ADD PDB 4ADE http://www.ebi.ac.uk/pdbe-srv/view/entry/4ADE PDBsum 4ADB http://www.ebi.ac.uk/pdbsum/4ADB PDBsum 4ADC http://www.ebi.ac.uk/pdbsum/4ADC PDBsum 4ADD http://www.ebi.ac.uk/pdbsum/4ADD PDBsum 4ADE http://www.ebi.ac.uk/pdbsum/4ADE PROSITE PS00600 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00600 PSORT swissprot:ASTC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ASTC_ECOLI PSORT-B swissprot:ASTC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ASTC_ECOLI PSORT2 swissprot:ASTC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ASTC_ECOLI Pfam PF00202 http://pfam.xfam.org/family/PF00202 Phobius swissprot:ASTC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ASTC_ECOLI PhylomeDB P77581 http://phylomedb.org/?seqid=P77581 ProteinModelPortal P77581 http://www.proteinmodelportal.org/query/uniprot/P77581 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9696779 http://www.ncbi.nlm.nih.gov/pubmed/9696779 PubMed 9696780 http://www.ncbi.nlm.nih.gov/pubmed/9696780 RefSeq NP_416262 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416262 RefSeq WP_000081983 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000081983 SMR P77581 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77581 STRING 511145.b1748 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1748&targetmode=cogs STRING COG0160 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0160&targetmode=cogs SUPFAM SSF53383 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53383 TIGRFAMs TIGR00707 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00707 TIGRFAMs TIGR03246 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03246 UniProtKB ASTC_ECOLI http://www.uniprot.org/uniprot/ASTC_ECOLI UniProtKB-AC P77581 http://www.uniprot.org/uniprot/P77581 charge swissprot:ASTC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ASTC_ECOLI eggNOG COG4992 http://eggnogapi.embl.de/nog_data/html/tree/COG4992 eggNOG ENOG4105C8Y http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C8Y epestfind swissprot:ASTC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ASTC_ECOLI garnier swissprot:ASTC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ASTC_ECOLI helixturnhelix swissprot:ASTC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ASTC_ECOLI hmoment swissprot:ASTC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ASTC_ECOLI iep swissprot:ASTC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ASTC_ECOLI inforesidue swissprot:ASTC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ASTC_ECOLI octanol swissprot:ASTC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ASTC_ECOLI pepcoil swissprot:ASTC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ASTC_ECOLI pepdigest swissprot:ASTC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ASTC_ECOLI pepinfo swissprot:ASTC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ASTC_ECOLI pepnet swissprot:ASTC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ASTC_ECOLI pepstats swissprot:ASTC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ASTC_ECOLI pepwheel swissprot:ASTC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ASTC_ECOLI pepwindow swissprot:ASTC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ASTC_ECOLI sigcleave swissprot:ASTC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ASTC_ECOLI ## Database ID URL or Descriptions # BioGrid 4262822 260 # EcoGene EG14233 cusC # FUNCTION CUSC_ECOLI Forms pores that allow passive diffusion of cations across the outer membrane. Part of a cation efflux system that mediates resistance to copper and silver. In pathogenic strains it allows the bacteria to invade brain microvascular endothelial cells (BMEC) thus allowing it to cross the blood-brain barrier and cause neonatal meningitis. {ECO 0000269|PubMed 11399769, ECO 0000269|PubMed 12813074, ECO 0000269|PubMed 21249122}. # GO_component GO:0009279 cell outer membrane; IEA:UniProtKB-SubCell. # GO_component GO:0046930 pore complex; IEA:UniProtKB-KW. # GO_function GO:0005375 copper ion transmembrane transporter activity; IGI:EcoCyc. # GO_function GO:0005507 copper ion binding; IGI:EcoCyc. # GO_function GO:0015288 porin activity; IEA:UniProtKB-KW. # GO_function GO:0019992 diacylglycerol binding; IDA:UniProtKB. # GO_process GO:0006878 cellular copper ion homeostasis; IGI:EcoCyc. # GO_process GO:0010272 response to silver ion; IMP:EcoCyc. # GO_process GO:0010273 detoxification of copper ion; IGI:EcoCyc. # GO_process GO:0018345 protein palmitoylation; IDA:UniProtKB. # GO_process GO:0046688 response to copper ion; IMP:EcoliWiki. # GO_process GO:0060003 copper ion export; IGI:EcoCyc. # GO_process GO:0070207 protein homotrimerization; IDA:UniProtKB. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043234 protein complex # GOslim_function GO:0008289 lipid binding # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0042592 homeostatic process # GOslim_process GO:0055085 transmembrane transport # INDUCTION Transcriptionally regulated by CusR in response to copper and silver ions. {ECO:0000269|PubMed 11283292}. # InterPro IPR003423 OMP_efflux # InterPro IPR010131 RND_efflux_OM_lipoprot_NodT # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02020 Two-component system # MISCELLANEOUS CUSC_ECOLI The cus system plays an important role in copper tolerance under anaerobic growth and, under extreme copper stress, in aerobic growth. # Organism CUSC_ECOLI Escherichia coli (strain K12) # PATRIC 32116312 VBIEscCol129921_0596 # PDB 3PIK X-ray; 2.30 A; A=18-457 # PDB 4K34 X-ray; 2.69 A; A/B=18-457 # PDB 4K7K X-ray; 2.53 A; A/B=18-457 # PDB 4K7R X-ray; 2.09 A; A=18-457 # PIR B64790 B64790 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF02321 OEP; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CUSC_ECOLI Cation efflux system protein CusC # RefSeq NP_415104 NC_000913.3 # RefSeq WP_000074234 NZ_LN832404.1 # SIMILARITY Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. {ECO 0000305}. # SUBCELLULAR LOCATION CUSC_ECOLI Cell outer membrane {ECO 0000269|PubMed 21249122}; Multi-pass membrane protein {ECO 0000269|PubMed 21249122}. Cell outer membrane {ECO 0000269|PubMed 21249122}; Lipid-anchor {ECO 0000255|PROSITE- ProRule PRU00303, ECO 0000269|PubMed 21249122}. # SUBUNIT Homotrimer. Component of the cus efflux system composed of CusA, CusB, CusC and CusF. {ECO:0000269|PubMed 21249122}. # TCDB 1.B.17.3 the outer membrane factor (omf) family # TIGRFAMs TIGR01845 outer_NodT # eggNOG COG1538 LUCA # eggNOG ENOG4105ENJ Bacteria BLAST swissprot:CUSC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CUSC_ECOLI BioCyc ECOL316407:JW0561-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0561-MONOMER BioCyc EcoCyc:G6320-MONOMER http://biocyc.org/getid?id=EcoCyc:G6320-MONOMER BioCyc MetaCyc:G6320-MONOMER http://biocyc.org/getid?id=MetaCyc:G6320-MONOMER COG COG1538 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1538 DIP DIP-9347N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9347N DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M104122200 http://dx.doi.org/10.1074/jbc.M104122200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.20.5864-5871.2000 http://dx.doi.org/10.1128/JB.182.20.5864-5871.2000 DOI 10.1128/JB.185.13.3804-3812.2003 http://dx.doi.org/10.1128/JB.185.13.3804-3812.2003 DOI 10.1371/journal.pone.0015610 http://dx.doi.org/10.1371/journal.pone.0015610 EMBL AF094824 http://www.ebi.ac.uk/ena/data/view/AF094824 EMBL AF245661 http://www.ebi.ac.uk/ena/data/view/AF245661 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB3984 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3984 EcoGene EG14233 http://www.ecogene.org/geneInfo.php?eg_id=EG14233 EnsemblBacteria AAC73673 http://www.ensemblgenomes.org/id/AAC73673 EnsemblBacteria AAC73673 http://www.ensemblgenomes.org/id/AAC73673 EnsemblBacteria BAA35206 http://www.ensemblgenomes.org/id/BAA35206 EnsemblBacteria BAA35206 http://www.ensemblgenomes.org/id/BAA35206 EnsemblBacteria BAA35206 http://www.ensemblgenomes.org/id/BAA35206 EnsemblBacteria b0572 http://www.ensemblgenomes.org/id/b0572 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0046930 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046930 GO_function GO:0005375 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005375 GO_function GO:0005507 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005507 GO_function GO:0015288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015288 GO_function GO:0019992 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019992 GO_process GO:0006878 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006878 GO_process GO:0010272 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010272 GO_process GO:0010273 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010273 GO_process GO:0018345 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018345 GO_process GO:0046688 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046688 GO_process GO:0060003 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060003 GO_process GO:0070207 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070207 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0008289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 946288 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946288 HOGENOM HOG000111955 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000111955&db=HOGENOM6 InParanoid P77211 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77211 InterPro IPR003423 http://www.ebi.ac.uk/interpro/entry/IPR003423 InterPro IPR010131 http://www.ebi.ac.uk/interpro/entry/IPR010131 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0561 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0561 KEGG_Gene eco:b0572 http://www.genome.jp/dbget-bin/www_bget?eco:b0572 KEGG_Orthology KO:K07796 http://www.genome.jp/dbget-bin/www_bget?KO:K07796 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA MIESTRA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MIESTRA PDB 3PIK http://www.ebi.ac.uk/pdbe-srv/view/entry/3PIK PDB 4K34 http://www.ebi.ac.uk/pdbe-srv/view/entry/4K34 PDB 4K7K http://www.ebi.ac.uk/pdbe-srv/view/entry/4K7K PDB 4K7R http://www.ebi.ac.uk/pdbe-srv/view/entry/4K7R PDBsum 3PIK http://www.ebi.ac.uk/pdbsum/3PIK PDBsum 4K34 http://www.ebi.ac.uk/pdbsum/4K34 PDBsum 4K7K http://www.ebi.ac.uk/pdbsum/4K7K PDBsum 4K7R http://www.ebi.ac.uk/pdbsum/4K7R PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:CUSC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CUSC_ECOLI PSORT-B swissprot:CUSC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CUSC_ECOLI PSORT2 swissprot:CUSC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CUSC_ECOLI Pfam PF02321 http://pfam.xfam.org/family/PF02321 Phobius swissprot:CUSC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CUSC_ECOLI PhylomeDB P77211 http://phylomedb.org/?seqid=P77211 ProteinModelPortal P77211 http://www.proteinmodelportal.org/query/uniprot/P77211 PubMed 10225861 http://www.ncbi.nlm.nih.gov/pubmed/10225861 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 11004187 http://www.ncbi.nlm.nih.gov/pubmed/11004187 PubMed 11283292 http://www.ncbi.nlm.nih.gov/pubmed/11283292 PubMed 11399769 http://www.ncbi.nlm.nih.gov/pubmed/11399769 PubMed 12813074 http://www.ncbi.nlm.nih.gov/pubmed/12813074 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21249122 http://www.ncbi.nlm.nih.gov/pubmed/21249122 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415104 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415104 RefSeq WP_000074234 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000074234 SMR P77211 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77211 STRING 511145.b0572 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0572&targetmode=cogs STRING COG1538 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1538&targetmode=cogs TCDB 1.B.17.3 http://www.tcdb.org/search/result.php?tc=1.B.17.3 TIGRFAMs TIGR01845 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01845 UniProtKB CUSC_ECOLI http://www.uniprot.org/uniprot/CUSC_ECOLI UniProtKB-AC P77211 http://www.uniprot.org/uniprot/P77211 charge swissprot:CUSC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CUSC_ECOLI eggNOG COG1538 http://eggnogapi.embl.de/nog_data/html/tree/COG1538 eggNOG ENOG4105ENJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ENJ epestfind swissprot:CUSC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CUSC_ECOLI garnier swissprot:CUSC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CUSC_ECOLI helixturnhelix swissprot:CUSC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CUSC_ECOLI hmoment swissprot:CUSC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CUSC_ECOLI iep swissprot:CUSC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CUSC_ECOLI inforesidue swissprot:CUSC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CUSC_ECOLI octanol swissprot:CUSC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CUSC_ECOLI pepcoil swissprot:CUSC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CUSC_ECOLI pepdigest swissprot:CUSC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CUSC_ECOLI pepinfo swissprot:CUSC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CUSC_ECOLI pepnet swissprot:CUSC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CUSC_ECOLI pepstats swissprot:CUSC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CUSC_ECOLI pepwheel swissprot:CUSC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CUSC_ECOLI pepwindow swissprot:CUSC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CUSC_ECOLI sigcleave swissprot:CUSC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CUSC_ECOLI ## Database ID URL or Descriptions # BioGrid 4260182 15 # EcoGene EG13781 yddJ # IntAct P76122 3 # Organism YDDJ_ECOLI Escherichia coli (strain K12) # PATRIC 32118232 VBIEscCol129921_1536 # PIR A64900 A64900 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDDJ_ECOLI Uncharacterized protein YddJ BLAST swissprot:YDDJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDDJ_ECOLI BioCyc ECOL316407:JW1466-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1466-MONOMER BioCyc EcoCyc:G6771-MONOMER http://biocyc.org/getid?id=EcoCyc:G6771-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3543 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3543 EcoGene EG13781 http://www.ecogene.org/geneInfo.php?eg_id=EG13781 EnsemblBacteria BAE76449 http://www.ensemblgenomes.org/id/BAE76449 EnsemblBacteria BAE76449 http://www.ensemblgenomes.org/id/BAE76449 EnsemblBacteria BAE76449 http://www.ensemblgenomes.org/id/BAE76449 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv HOGENOM HOG000054881 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000054881&db=HOGENOM6 IntAct P76122 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76122* KEGG_Gene ecj:JW1466 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1466 OMA DADNELF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DADNELF PSORT swissprot:YDDJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDDJ_ECOLI PSORT-B swissprot:YDDJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDDJ_ECOLI PSORT2 swissprot:YDDJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDDJ_ECOLI Phobius swissprot:YDDJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDDJ_ECOLI ProteinModelPortal P76122 http://www.proteinmodelportal.org/query/uniprot/P76122 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 STRING 511145.b1470 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1470&targetmode=cogs UniProtKB YDDJ_ECOLI http://www.uniprot.org/uniprot/YDDJ_ECOLI UniProtKB-AC P76122 http://www.uniprot.org/uniprot/P76122 charge swissprot:YDDJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDDJ_ECOLI epestfind swissprot:YDDJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDDJ_ECOLI garnier swissprot:YDDJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDDJ_ECOLI helixturnhelix swissprot:YDDJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDDJ_ECOLI hmoment swissprot:YDDJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDDJ_ECOLI iep swissprot:YDDJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDDJ_ECOLI inforesidue swissprot:YDDJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDDJ_ECOLI octanol swissprot:YDDJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDDJ_ECOLI pepcoil swissprot:YDDJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDDJ_ECOLI pepdigest swissprot:YDDJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDDJ_ECOLI pepinfo swissprot:YDDJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDDJ_ECOLI pepnet swissprot:YDDJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDDJ_ECOLI pepstats swissprot:YDDJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDDJ_ECOLI pepwheel swissprot:YDDJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDDJ_ECOLI pepwindow swissprot:YDDJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDDJ_ECOLI sigcleave swissprot:YDDJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDDJ_ECOLI ## Database ID URL or Descriptions # CAUTION There is no equivalent of this gene in strain K12 / MG1655. {ECO 0000305}. # FUNCTION INSC8_ECOLI Involved in the transposition of the insertion sequence IS2. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 1.10.10.60 -; 1. # InterPro IPR002514 Transposase_8 # InterPro IPR009057 Homeodomain-like # Organism INSC8_ECOLI Escherichia coli (strain K12) # Pfam PF01527 HTH_Tnp_1 # RecName INSC8_ECOLI Transposase InsC for insertion element IS2-8 # RefSeq WP_000567766 NZ_LN832404.1 # SIMILARITY Belongs to the transposase 8 family. {ECO 0000305}. # SUPFAM SSF46689 SSF46689 # eggNOG COG2963 LUCA # eggNOG ENOG4108ZQS Bacteria BLAST swissprot:INSC8_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSC8_ECOLI DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EnsemblBacteria BAE76371 http://www.ensemblgenomes.org/id/BAE76371 EnsemblBacteria BAE76371 http://www.ensemblgenomes.org/id/BAE76371 EnsemblBacteria BAE76371 http://www.ensemblgenomes.org/id/BAE76371 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 InterPro IPR002514 http://www.ebi.ac.uk/interpro/entry/IPR002514 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 KEGG_Gene ecj:JW5900 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5900 PSORT swissprot:INSC8_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSC8_ECOLI PSORT-B swissprot:INSC8_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSC8_ECOLI PSORT2 swissprot:INSC8_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSC8_ECOLI Pfam PF01527 http://pfam.xfam.org/family/PF01527 Phobius swissprot:INSC8_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSC8_ECOLI PhylomeDB P0CF47 http://phylomedb.org/?seqid=P0CF47 ProteinModelPortal P0CF47 http://www.proteinmodelportal.org/query/uniprot/P0CF47 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 RefSeq WP_000567766 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000567766 STRING 511145.b4272 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4272&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 UniProtKB INSC8_ECOLI http://www.uniprot.org/uniprot/INSC8_ECOLI UniProtKB-AC P0CF47 http://www.uniprot.org/uniprot/P0CF47 charge swissprot:INSC8_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSC8_ECOLI eggNOG COG2963 http://eggnogapi.embl.de/nog_data/html/tree/COG2963 eggNOG ENOG4108ZQS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZQS epestfind swissprot:INSC8_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSC8_ECOLI garnier swissprot:INSC8_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSC8_ECOLI helixturnhelix swissprot:INSC8_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSC8_ECOLI hmoment swissprot:INSC8_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSC8_ECOLI iep swissprot:INSC8_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSC8_ECOLI inforesidue swissprot:INSC8_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSC8_ECOLI octanol swissprot:INSC8_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSC8_ECOLI pepcoil swissprot:INSC8_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSC8_ECOLI pepdigest swissprot:INSC8_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSC8_ECOLI pepinfo swissprot:INSC8_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSC8_ECOLI pepnet swissprot:INSC8_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSC8_ECOLI pepstats swissprot:INSC8_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSC8_ECOLI pepwheel swissprot:INSC8_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSC8_ECOLI pepwindow swissprot:INSC8_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSC8_ECOLI sigcleave swissprot:INSC8_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSC8_ECOLI ## Database ID URL or Descriptions # AltName RMLA2_ECOLI dTDP-glucose pyrophosphorylase 2 # AltName RMLA2_ECOLI dTDP-glucose synthase 2 # BioGrid 4261364 234 # CATALYTIC ACTIVITY dTTP + alpha-D-glucose 1-phosphate = diphosphate + dTDP-alpha-D-glucose. {ECO:0000269|PubMed 7559340}. # CDD cd02538 G1P_TT_short # COFACTOR RMLA2_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 12171937}; Note=Binds 1 Mg(2+) ion per subunit. {ECO 0000269|PubMed 12171937}; # EcoGene EG11454 rffH # FUNCTION RMLA2_ECOLI Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. {ECO 0000269|PubMed 7559340}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IDA:UniProtKB. # GO_function GO:0008879 glucose-1-phosphate thymidylyltransferase activity; IDA:UniProtKB. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0009246 enterobacterial common antigen biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0045226 extracellular polysaccharide biosynthetic process; IDA:UniProtKB. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.90.550.10 -; 1. # IntAct P61887 5 # InterPro IPR005835 NTP_transferase_dom # InterPro IPR005907 G1P_thy_trans_s # InterPro IPR029044 Nucleotide-diphossugar_trans # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00521 Streptomycin biosynthesis # KEGG_Pathway ko00523 Polyketide sugar unit biosynthesis # Organism RMLA2_ECOLI Escherichia coli (strain K12) # PANTHER PTHR22572:SF105 PTHR22572:SF105 # PATHWAY Bacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis. {ECO:0000269|PubMed 7559340}. # PATHWAY Nucleotide-sugar biosynthesis; dTDP-4-acetamido-4,6- dideoxygalactose biosynthesis. {ECO:0000269|PubMed 7559340}. # PATRIC 32123071 VBIEscCol129921_3905 # PDB 1MC3 X-ray; 2.60 A; A/B=1-293 # PIR H65182 H65182 # Pfam PF00483 NTP_transferase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RMLA2_ECOLI Glucose-1-phosphate thymidylyltransferase 2 # RefSeq NP_418236 NC_000913.3 # RefSeq WP_000676056 NZ_LN832404.1 # SIMILARITY Belongs to the glucose-1-phosphate thymidylyltransferase family. {ECO 0000305}. # SUBUNIT Homotetramer; arranged as a dimer of dimers. {ECO:0000269|PubMed 12171937}. # SUPFAM SSF53448 SSF53448 # TIGRFAMs TIGR01207 rmlA # eggNOG COG1209 LUCA # eggNOG ENOG4108I19 Bacteria BLAST swissprot:RMLA2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RMLA2_ECOLI BioCyc ECOL316407:JW3763-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3763-MONOMER BioCyc EcoCyc:DTDPGLUCOSEPP2-MONOMER http://biocyc.org/getid?id=EcoCyc:DTDPGLUCOSEPP2-MONOMER BioCyc MetaCyc:DTDPGLUCOSEPP2-MONOMER http://biocyc.org/getid?id=MetaCyc:DTDPGLUCOSEPP2-MONOMER COG COG1209 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1209 DIP DIP-10689N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10689N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M206932200 http://dx.doi.org/10.1074/jbc.M206932200 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.7.24 {ECO:0000269|PubMed:7559340} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.24 {ECO:0000269|PubMed:7559340} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.7.24 {ECO:0000269|PubMed:7559340} http://enzyme.expasy.org/EC/2.7.7.24 {ECO:0000269|PubMed:7559340} EchoBASE EB1423 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1423 EcoGene EG11454 http://www.ecogene.org/geneInfo.php?eg_id=EG11454 EnsemblBacteria AAC76794 http://www.ensemblgenomes.org/id/AAC76794 EnsemblBacteria AAC76794 http://www.ensemblgenomes.org/id/AAC76794 EnsemblBacteria BAE77509 http://www.ensemblgenomes.org/id/BAE77509 EnsemblBacteria BAE77509 http://www.ensemblgenomes.org/id/BAE77509 EnsemblBacteria BAE77509 http://www.ensemblgenomes.org/id/BAE77509 EnsemblBacteria b3789 http://www.ensemblgenomes.org/id/b3789 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0008879 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008879 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0009246 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009246 GO_process GO:0045226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045226 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.90.550.10 http://www.cathdb.info/version/latest/superfamily/3.90.550.10 GeneID 948299 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948299 HOGENOM HOG000283473 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000283473&db=HOGENOM6 InParanoid P61887 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P61887 IntAct P61887 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P61887* IntEnz 2.7.7.24 {ECO:0000269|PubMed:7559340} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.24 {ECO:0000269|PubMed:7559340} InterPro IPR005835 http://www.ebi.ac.uk/interpro/entry/IPR005835 InterPro IPR005907 http://www.ebi.ac.uk/interpro/entry/IPR005907 InterPro IPR029044 http://www.ebi.ac.uk/interpro/entry/IPR029044 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3763 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3763 KEGG_Gene eco:b3789 http://www.genome.jp/dbget-bin/www_bget?eco:b3789 KEGG_Orthology KO:K00973 http://www.genome.jp/dbget-bin/www_bget?KO:K00973 KEGG_Pathway ko00521 http://www.genome.jp/kegg-bin/show_pathway?ko00521 KEGG_Pathway ko00523 http://www.genome.jp/kegg-bin/show_pathway?ko00523 KEGG_Reaction rn:R02328 http://www.genome.jp/dbget-bin/www_bget?rn:R02328 OMA IMLSGIR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IMLSGIR PANTHER PTHR22572:SF105 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22572:SF105 PDB 1MC3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1MC3 PDBsum 1MC3 http://www.ebi.ac.uk/pdbsum/1MC3 PSORT swissprot:RMLA2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RMLA2_ECOLI PSORT-B swissprot:RMLA2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RMLA2_ECOLI PSORT2 swissprot:RMLA2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RMLA2_ECOLI Pfam PF00483 http://pfam.xfam.org/family/PF00483 Phobius swissprot:RMLA2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RMLA2_ECOLI PhylomeDB P61887 http://phylomedb.org/?seqid=P61887 ProteinModelPortal P61887 http://www.proteinmodelportal.org/query/uniprot/P61887 PubMed 12171937 http://www.ncbi.nlm.nih.gov/pubmed/12171937 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7559340 http://www.ncbi.nlm.nih.gov/pubmed/7559340 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418236 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418236 RefSeq WP_000676056 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000676056 SMR P61887 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P61887 STRING 511145.b3789 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3789&targetmode=cogs STRING COG1209 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1209&targetmode=cogs SUPFAM SSF53448 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53448 TIGRFAMs TIGR01207 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01207 UniProtKB RMLA2_ECOLI http://www.uniprot.org/uniprot/RMLA2_ECOLI UniProtKB-AC P61887 http://www.uniprot.org/uniprot/P61887 charge swissprot:RMLA2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RMLA2_ECOLI eggNOG COG1209 http://eggnogapi.embl.de/nog_data/html/tree/COG1209 eggNOG ENOG4108I19 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108I19 epestfind swissprot:RMLA2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RMLA2_ECOLI garnier swissprot:RMLA2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RMLA2_ECOLI helixturnhelix swissprot:RMLA2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RMLA2_ECOLI hmoment swissprot:RMLA2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RMLA2_ECOLI iep swissprot:RMLA2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RMLA2_ECOLI inforesidue swissprot:RMLA2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RMLA2_ECOLI octanol swissprot:RMLA2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RMLA2_ECOLI pepcoil swissprot:RMLA2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RMLA2_ECOLI pepdigest swissprot:RMLA2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RMLA2_ECOLI pepinfo swissprot:RMLA2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RMLA2_ECOLI pepnet swissprot:RMLA2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RMLA2_ECOLI pepstats swissprot:RMLA2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RMLA2_ECOLI pepwheel swissprot:RMLA2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RMLA2_ECOLI pepwindow swissprot:RMLA2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RMLA2_ECOLI sigcleave swissprot:RMLA2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RMLA2_ECOLI ## Database ID URL or Descriptions # BioGrid 4263148 10 # EcoGene EG11260 yifB # GO_function GO:0004176 ATP-dependent peptidase activity; ISS:EcoCyc. # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0016887 ATPase activity # Gene3D 3.30.230.10 -; 1. # Gene3D 3.40.50.300 -; 1. # IntAct P22787 7 # InterPro IPR000523 Mg_chelatse_chII_dom # InterPro IPR003593 AAA+_ATPase # InterPro IPR004482 Mg_chelat-rel # InterPro IPR014721 Ribosomal_S5_D2-typ_fold_subgr # InterPro IPR020568 Ribosomal_S5_D2-typ_fold # InterPro IPR025158 Mg_chelat-rel_C # InterPro IPR027417 P-loop_NTPase # Organism YIFB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR32039:SF7 PTHR32039:SF7 # PATRIC 32123027 VBIEscCol129921_3883 # PIR JQ0872 JQ0872 # Pfam PF01078 Mg_chelatase # Pfam PF13335 Mg_chelatase_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIFB_ECOLI Uncharacterized protein YifB # RefSeq NP_418214 NC_000913.3 # RefSeq WP_000058964 NZ_LN832404.1 # SEQUENCE CAUTION YIFB_ECOLI Sequence=AAA24609.1; Type=Erroneous initiation; Evidence={ECO 0000305}; Sequence=AAA24610.1; Type=Erroneous initiation; Evidence={ECO 0000305}; Sequence=AAA67569.1; Type=Erroneous initiation; Evidence={ECO 0000305}; Sequence=BAE77530.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the Mg-chelatase subunits D/I family. ComM subfamily. {ECO 0000305}. # SMART SM00382 AAA # SUPFAM SSF52540 SSF52540 # SUPFAM SSF54211 SSF54211 # TIGRFAMs TIGR00368 TIGR00368 # eggNOG COG0606 LUCA # eggNOG ENOG4105C0P Bacteria BLAST swissprot:YIFB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIFB_ECOLI BioCyc ECOL316407:JW3738-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3738-MONOMER BioCyc EcoCyc:EG11260-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11260-MONOMER COG COG0606 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0606 DOI 10.1016/0378-1119(91)90005-V http://dx.doi.org/10.1016/0378-1119(91)90005-V DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M37337 http://www.ebi.ac.uk/ena/data/view/M37337 EMBL M37337 http://www.ebi.ac.uk/ena/data/view/M37337 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1240 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1240 EcoGene EG11260 http://www.ecogene.org/geneInfo.php?eg_id=EG11260 EnsemblBacteria AAC77486 http://www.ensemblgenomes.org/id/AAC77486 EnsemblBacteria AAC77486 http://www.ensemblgenomes.org/id/AAC77486 EnsemblBacteria BAE77530 http://www.ensemblgenomes.org/id/BAE77530 EnsemblBacteria BAE77530 http://www.ensemblgenomes.org/id/BAE77530 EnsemblBacteria BAE77530 http://www.ensemblgenomes.org/id/BAE77530 EnsemblBacteria b3765 http://www.ensemblgenomes.org/id/b3765 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004176 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004176 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 Gene3D 3.30.230.10 http://www.cathdb.info/version/latest/superfamily/3.30.230.10 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948282 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948282 HOGENOM HOG000246698 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000246698&db=HOGENOM6 InParanoid P22787 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P22787 IntAct P22787 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P22787* InterPro IPR000523 http://www.ebi.ac.uk/interpro/entry/IPR000523 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR004482 http://www.ebi.ac.uk/interpro/entry/IPR004482 InterPro IPR014721 http://www.ebi.ac.uk/interpro/entry/IPR014721 InterPro IPR020568 http://www.ebi.ac.uk/interpro/entry/IPR020568 InterPro IPR025158 http://www.ebi.ac.uk/interpro/entry/IPR025158 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Gene ecj:JW3738 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3738 KEGG_Gene eco:b3765 http://www.genome.jp/dbget-bin/www_bget?eco:b3765 KEGG_Orthology KO:K07391 http://www.genome.jp/dbget-bin/www_bget?KO:K07391 OMA PCPCGYF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PCPCGYF PANTHER PTHR32039:SF7 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32039:SF7 PSORT swissprot:YIFB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIFB_ECOLI PSORT-B swissprot:YIFB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIFB_ECOLI PSORT2 swissprot:YIFB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIFB_ECOLI Pfam PF01078 http://pfam.xfam.org/family/PF01078 Pfam PF13335 http://pfam.xfam.org/family/PF13335 Phobius swissprot:YIFB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIFB_ECOLI PhylomeDB P22787 http://phylomedb.org/?seqid=P22787 ProteinModelPortal P22787 http://www.proteinmodelportal.org/query/uniprot/P22787 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1995430 http://www.ncbi.nlm.nih.gov/pubmed/1995430 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418214 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418214 RefSeq WP_000058964 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000058964 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 STRING 511145.b3765 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3765&targetmode=cogs STRING COG0606 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0606&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SUPFAM SSF54211 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54211 TIGRFAMs TIGR00368 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00368 UniProtKB YIFB_ECOLI http://www.uniprot.org/uniprot/YIFB_ECOLI UniProtKB-AC P22787 http://www.uniprot.org/uniprot/P22787 charge swissprot:YIFB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIFB_ECOLI eggNOG COG0606 http://eggnogapi.embl.de/nog_data/html/tree/COG0606 eggNOG ENOG4105C0P http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C0P epestfind swissprot:YIFB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIFB_ECOLI garnier swissprot:YIFB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIFB_ECOLI helixturnhelix swissprot:YIFB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIFB_ECOLI hmoment swissprot:YIFB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIFB_ECOLI iep swissprot:YIFB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIFB_ECOLI inforesidue swissprot:YIFB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIFB_ECOLI octanol swissprot:YIFB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIFB_ECOLI pepcoil swissprot:YIFB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIFB_ECOLI pepdigest swissprot:YIFB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIFB_ECOLI pepinfo swissprot:YIFB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIFB_ECOLI pepnet swissprot:YIFB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIFB_ECOLI pepstats swissprot:YIFB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIFB_ECOLI pepwheel swissprot:YIFB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIFB_ECOLI pepwindow swissprot:YIFB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIFB_ECOLI sigcleave swissprot:YIFB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIFB_ECOLI ## Database ID URL or Descriptions # BioGrid 4259290 12 # EcoGene EG11206 yjaA # GO_process GO:0044011 single-species biofilm formation on inanimate substrate; IMP:EcoCyc. # GO_process GO:0070301 cellular response to hydrogen peroxide; IMP:EcoCyc. # GO_process GO:0071468 cellular response to acidic pH; IMP:EcoCyc. # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # IntAct P09162 9 # Organism YJAA_ECOLI Escherichia coli (strain K12) # PATRIC 32123549 VBIEscCol129921_4123 # PIR A24340 Q3ECE4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJAA_ECOLI Uncharacterized protein YjaA # RefSeq NP_418435 NC_000913.3 # RefSeq WP_001326558 NZ_LN832404.1 # eggNOG ENOG41062WK Bacteria # eggNOG ENOG4112C2G LUCA BLAST swissprot:YJAA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJAA_ECOLI BioCyc ECOL316407:JW3971-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3971-MONOMER BioCyc EcoCyc:EG11206-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11206-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/13.15.5515 http://dx.doi.org/10.1093/nar/13.15.5515 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X02800 http://www.ebi.ac.uk/ena/data/view/X02800 EchoBASE EB1191 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1191 EcoGene EG11206 http://www.ecogene.org/geneInfo.php?eg_id=EG11206 EnsemblBacteria AAC76981 http://www.ensemblgenomes.org/id/AAC76981 EnsemblBacteria AAC76981 http://www.ensemblgenomes.org/id/AAC76981 EnsemblBacteria BAE78013 http://www.ensemblgenomes.org/id/BAE78013 EnsemblBacteria BAE78013 http://www.ensemblgenomes.org/id/BAE78013 EnsemblBacteria BAE78013 http://www.ensemblgenomes.org/id/BAE78013 EnsemblBacteria b4011 http://www.ensemblgenomes.org/id/b4011 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0044011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044011 GO_process GO:0070301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070301 GO_process GO:0071468 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071468 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 948515 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948515 HOGENOM HOG000126798 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126798&db=HOGENOM6 IntAct P09162 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P09162* KEGG_Gene ecj:JW3971 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3971 KEGG_Gene eco:b4011 http://www.genome.jp/dbget-bin/www_bget?eco:b4011 OMA VEERAIM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VEERAIM PSORT swissprot:YJAA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJAA_ECOLI PSORT-B swissprot:YJAA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJAA_ECOLI PSORT2 swissprot:YJAA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJAA_ECOLI Phobius swissprot:YJAA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJAA_ECOLI ProteinModelPortal P09162 http://www.proteinmodelportal.org/query/uniprot/P09162 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2412207 http://www.ncbi.nlm.nih.gov/pubmed/2412207 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418435 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418435 RefSeq WP_001326558 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001326558 STRING 511145.b4011 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4011&targetmode=cogs UniProtKB YJAA_ECOLI http://www.uniprot.org/uniprot/YJAA_ECOLI UniProtKB-AC P09162 http://www.uniprot.org/uniprot/P09162 charge swissprot:YJAA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJAA_ECOLI eggNOG ENOG41062WK http://eggnogapi.embl.de/nog_data/html/tree/ENOG41062WK eggNOG ENOG4112C2G http://eggnogapi.embl.de/nog_data/html/tree/ENOG4112C2G epestfind swissprot:YJAA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJAA_ECOLI garnier swissprot:YJAA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJAA_ECOLI helixturnhelix swissprot:YJAA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJAA_ECOLI hmoment swissprot:YJAA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJAA_ECOLI iep swissprot:YJAA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJAA_ECOLI inforesidue swissprot:YJAA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJAA_ECOLI octanol swissprot:YJAA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJAA_ECOLI pepcoil swissprot:YJAA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJAA_ECOLI pepdigest swissprot:YJAA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJAA_ECOLI pepinfo swissprot:YJAA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJAA_ECOLI pepnet swissprot:YJAA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJAA_ECOLI pepstats swissprot:YJAA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJAA_ECOLI pepwheel swissprot:YJAA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJAA_ECOLI pepwindow swissprot:YJAA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJAA_ECOLI sigcleave swissprot:YJAA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJAA_ECOLI ## Database ID URL or Descriptions # AltName PTSO_ECOLI Nitrogen-related HPr # BioGrid 4261609 9 # CATALYTIC ACTIVITY PTSO_ECOLI Protein NPr N(pi)-phospho-L-histidine + protein EIIA-Ntr = protein NPr + protein EIIA-Ntr N(tau)-phospho- L-histidine. # CDD cd00367 PTS-HPr_like # EcoGene EG12147 ptsO # FUNCTION PTSO_ECOLI Component of the phosphoenolpyruvate-dependent nitrogen- metabolic phosphotransferase system (nitrogen-metabolic PTS), that seems to be involved in regulating nitrogen metabolism. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein NPr by enzyme I-Ntr. Phospho-NPr then transfers it to EIIA-Ntr. Could function in the transcriptional regulation of sigma-54 dependent operons in conjunction with the NPr (PtsO) and EIIA-Ntr (PtsN) proteins. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0004674 protein serine/threonine kinase activity; IEA:UniProtKB-KW. # GO_function GO:0016772 transferase activity, transferring phosphorus-containing groups; IDA:EcoCyc. # GO_process GO:0006468 protein phosphorylation; IDA:EcoCyc. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW. # GO_process GO:0010243 response to organonitrogen compound; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016301 kinase activity # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # Gene3D 3.30.1340.10 -; 1. # InterPro IPR000032 HPr-like # InterPro IPR001020 PTS_HPr_His_P_site # InterPro IPR002114 PTS_HPr_Ser_P_site # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02060 Phosphotransferase system (PTS) # MISCELLANEOUS Enzyme I of the sugar PTS has been shown in PubMed 7876255 to phosphorylate NPr of the nitrogen-metabolic PTS, though much less efficiently than it does HPr. This process may link carbon and nitrogen assimilation. # Organism PTSO_ECOLI Escherichia coli (strain K12) # PATRIC 32121832 VBIEscCol129921_3300 # PDB 5T17 NMR; -; A=1-85 # PIR I76722 I76722 # PRINTS PR00107 PHOSPHOCPHPR # PROSITE PS00369 PTS_HPR_HIS # PROSITE PS00589 PTS_HPR_SER # PROSITE PS51350 PTS_HPR_DOM # Pfam PF00381 PTS-HPr # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PTSO_ECOLI Phosphocarrier protein NPr # RefSeq NP_417673 NC_000913.3 # RefSeq WP_000216791 NZ_LN832404.1 # SIMILARITY Belongs to the HPr family. {ECO 0000305}. # SIMILARITY Contains 1 HPr domain. {ECO:0000255|PROSITE- ProRule PRU00681}. # SUBCELLULAR LOCATION PTSO_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF55594 SSF55594 # TIGRFAMs TIGR01003 PTS_HPr_family # eggNOG COG1925 LUCA # eggNOG ENOG41080Z8 Bacteria BLAST swissprot:PTSO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTSO_ECOLI BioCyc ECOL316407:JW3173-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3173-MONOMER BioCyc EcoCyc:EG12147-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12147-MONOMER COG COG1925 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1925 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.270.9.4822 http://dx.doi.org/10.1074/jbc.270.9.4822 DOI 10.1099/13500872-140-5-1035 http://dx.doi.org/10.1099/13500872-140-5-1035 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.11.- http://www.genome.jp/dbget-bin/www_bget?EC:2.7.11.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U12684 http://www.ebi.ac.uk/ena/data/view/U12684 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL Z27094 http://www.ebi.ac.uk/ena/data/view/Z27094 ENZYME 2.7.11.- http://enzyme.expasy.org/EC/2.7.11.- EchoBASE EB2067 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2067 EcoGene EG12147 http://www.ecogene.org/geneInfo.php?eg_id=EG12147 EnsemblBacteria AAC76238 http://www.ensemblgenomes.org/id/AAC76238 EnsemblBacteria AAC76238 http://www.ensemblgenomes.org/id/AAC76238 EnsemblBacteria BAE77250 http://www.ensemblgenomes.org/id/BAE77250 EnsemblBacteria BAE77250 http://www.ensemblgenomes.org/id/BAE77250 EnsemblBacteria BAE77250 http://www.ensemblgenomes.org/id/BAE77250 EnsemblBacteria b3206 http://www.ensemblgenomes.org/id/b3206 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004674 GO_function GO:0016772 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016772 GO_process GO:0006468 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006468 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GO_process GO:0010243 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010243 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.30.1340.10 http://www.cathdb.info/version/latest/superfamily/3.30.1340.10 GeneID 947914 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947914 HOGENOM HOG000278398 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278398&db=HOGENOM6 InParanoid P0A9N0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9N0 IntEnz 2.7.11 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.11 InterPro IPR000032 http://www.ebi.ac.uk/interpro/entry/IPR000032 InterPro IPR001020 http://www.ebi.ac.uk/interpro/entry/IPR001020 InterPro IPR002114 http://www.ebi.ac.uk/interpro/entry/IPR002114 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3173 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3173 KEGG_Gene eco:b3206 http://www.genome.jp/dbget-bin/www_bget?eco:b3206 KEGG_Orthology KO:K08485 http://www.genome.jp/dbget-bin/www_bget?KO:K08485 KEGG_Pathway ko02060 http://www.genome.jp/kegg-bin/show_pathway?ko02060 OMA FIEVETD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FIEVETD PDB 5T17 http://www.ebi.ac.uk/pdbe-srv/view/entry/5T17 PDBsum 5T17 http://www.ebi.ac.uk/pdbsum/5T17 PRINTS PR00107 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00107 PROSITE PS00369 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00369 PROSITE PS00589 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00589 PROSITE PS51350 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51350 PSORT swissprot:PTSO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTSO_ECOLI PSORT-B swissprot:PTSO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTSO_ECOLI PSORT2 swissprot:PTSO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTSO_ECOLI Pfam PF00381 http://pfam.xfam.org/family/PF00381 Phobius swissprot:PTSO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTSO_ECOLI PhylomeDB P0A9N0 http://phylomedb.org/?seqid=P0A9N0 ProteinModelPortal P0A9N0 http://www.proteinmodelportal.org/query/uniprot/P0A9N0 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7876255 http://www.ncbi.nlm.nih.gov/pubmed/7876255 PubMed 8025669 http://www.ncbi.nlm.nih.gov/pubmed/8025669 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417673 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417673 RefSeq WP_000216791 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000216791 SMR P0A9N0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9N0 STRING 511145.b3206 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3206&targetmode=cogs STRING COG1925 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1925&targetmode=cogs SUPFAM SSF55594 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55594 TIGRFAMs TIGR01003 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01003 UniProtKB PTSO_ECOLI http://www.uniprot.org/uniprot/PTSO_ECOLI UniProtKB-AC P0A9N0 http://www.uniprot.org/uniprot/P0A9N0 charge swissprot:PTSO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTSO_ECOLI eggNOG COG1925 http://eggnogapi.embl.de/nog_data/html/tree/COG1925 eggNOG ENOG41080Z8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41080Z8 epestfind swissprot:PTSO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTSO_ECOLI garnier swissprot:PTSO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTSO_ECOLI helixturnhelix swissprot:PTSO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTSO_ECOLI hmoment swissprot:PTSO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTSO_ECOLI iep swissprot:PTSO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTSO_ECOLI inforesidue swissprot:PTSO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTSO_ECOLI octanol swissprot:PTSO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTSO_ECOLI pepcoil swissprot:PTSO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTSO_ECOLI pepdigest swissprot:PTSO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTSO_ECOLI pepinfo swissprot:PTSO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTSO_ECOLI pepnet swissprot:PTSO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTSO_ECOLI pepstats swissprot:PTSO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTSO_ECOLI pepwheel swissprot:PTSO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTSO_ECOLI pepwindow swissprot:PTSO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTSO_ECOLI sigcleave swissprot:PTSO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTSO_ECOLI ## Database ID URL or Descriptions # BioGrid 4262335 15 # COFACTOR YGFT_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000250}; Note=Binds 4 [4Fe-4S] clusters. May potentially bind 2 additional iron-sulfur clusters. {ECO 0000250}; # EcoGene EG13070 ygfT # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0016491 oxidoreductase activity; IBA:GO_Central. # GO_function GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor; IEA:InterPro. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0006537 glutamate biosynthetic process; IEA:InterPro. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.50.50.60 -; 3. # InterPro IPR006006 Glut_synth_ssu2 # InterPro IPR017896 4Fe4S_Fe-S-bd # InterPro IPR017900 4Fe4S_Fe_S_CS # InterPro IPR023753 FAD/NAD-binding_dom # InterPro IPR028261 DPD_II # Organism YGFT_ECOLI Escherichia coli (strain K12) # PATRIC 32121182 VBIEscCol129921_2979 # PIR G65072 G65072 # PROSITE PS00198 4FE4S_FER_1 # PROSITE PS51379 4FE4S_FER_2; 5 # Pfam PF07992 Pyr_redox_2 # Pfam PF13247 Fer4_11 # Pfam PF14691 Fer4_20 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGFT_ECOLI Uncharacterized protein YgfT # RefSeq NP_417363 NC_000913.3 # RefSeq WP_001350545 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA83068.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Contains 5 4Fe-4S ferredoxin-type domains. {ECO:0000255|PROSITE-ProRule PRU00711}. # TIGRFAMs TIGR01318 gltD_gamma_fam # eggNOG COG0493 LUCA # eggNOG COG1142 LUCA # eggNOG ENOG4105BZ8 Bacteria BLAST swissprot:YGFT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGFT_ECOLI BioCyc ECOL316407:JW5469-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5469-MONOMER BioCyc EcoCyc:G7506-MONOMER http://biocyc.org/getid?id=EcoCyc:G7506-MONOMER DIP DIP-12175N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12175N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 EchoBASE EB2881 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2881 EcoGene EG13070 http://www.ecogene.org/geneInfo.php?eg_id=EG13070 EnsemblBacteria AAC75925 http://www.ensemblgenomes.org/id/AAC75925 EnsemblBacteria AAC75925 http://www.ensemblgenomes.org/id/AAC75925 EnsemblBacteria BAE76952 http://www.ensemblgenomes.org/id/BAE76952 EnsemblBacteria BAE76952 http://www.ensemblgenomes.org/id/BAE76952 EnsemblBacteria BAE76952 http://www.ensemblgenomes.org/id/BAE76952 EnsemblBacteria b2887 http://www.ensemblgenomes.org/id/b2887 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0016639 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016639 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0006537 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006537 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 GeneID 949018 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949018 HOGENOM HOG000031439 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000031439&db=HOGENOM6 InParanoid Q46820 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46820 InterPro IPR006006 http://www.ebi.ac.uk/interpro/entry/IPR006006 InterPro IPR017896 http://www.ebi.ac.uk/interpro/entry/IPR017896 InterPro IPR017900 http://www.ebi.ac.uk/interpro/entry/IPR017900 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 InterPro IPR028261 http://www.ebi.ac.uk/interpro/entry/IPR028261 KEGG_Gene ecj:JW5469 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5469 KEGG_Gene eco:b2887 http://www.genome.jp/dbget-bin/www_bget?eco:b2887 OMA HAKPVRI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HAKPVRI PROSITE PS00198 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00198 PROSITE PS51379 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51379 PSORT swissprot:YGFT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGFT_ECOLI PSORT-B swissprot:YGFT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGFT_ECOLI PSORT2 swissprot:YGFT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGFT_ECOLI Pfam PF07992 http://pfam.xfam.org/family/PF07992 Pfam PF13247 http://pfam.xfam.org/family/PF13247 Pfam PF14691 http://pfam.xfam.org/family/PF14691 Phobius swissprot:YGFT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGFT_ECOLI PhylomeDB Q46820 http://phylomedb.org/?seqid=Q46820 ProteinModelPortal Q46820 http://www.proteinmodelportal.org/query/uniprot/Q46820 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417363 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417363 RefSeq WP_001350545 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001350545 SMR Q46820 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46820 STRING 511145.b2887 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2887&targetmode=cogs TIGRFAMs TIGR01318 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01318 UniProtKB YGFT_ECOLI http://www.uniprot.org/uniprot/YGFT_ECOLI UniProtKB-AC Q46820 http://www.uniprot.org/uniprot/Q46820 charge swissprot:YGFT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGFT_ECOLI eggNOG COG0493 http://eggnogapi.embl.de/nog_data/html/tree/COG0493 eggNOG COG1142 http://eggnogapi.embl.de/nog_data/html/tree/COG1142 eggNOG ENOG4105BZ8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZ8 epestfind swissprot:YGFT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGFT_ECOLI garnier swissprot:YGFT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGFT_ECOLI helixturnhelix swissprot:YGFT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGFT_ECOLI hmoment swissprot:YGFT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGFT_ECOLI iep swissprot:YGFT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGFT_ECOLI inforesidue swissprot:YGFT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGFT_ECOLI octanol swissprot:YGFT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGFT_ECOLI pepcoil swissprot:YGFT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGFT_ECOLI pepdigest swissprot:YGFT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGFT_ECOLI pepinfo swissprot:YGFT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGFT_ECOLI pepnet swissprot:YGFT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGFT_ECOLI pepstats swissprot:YGFT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGFT_ECOLI pepwheel swissprot:YGFT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGFT_ECOLI pepwindow swissprot:YGFT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGFT_ECOLI sigcleave swissprot:YGFT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGFT_ECOLI ## Database ID URL or Descriptions # BioGrid 4263019 9 # CDD cd06660 Aldo_ket_red # EcoGene EG11309 ydbC # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0016491 oxidoreductase activity; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # Gene3D 3.20.20.100 -; 1. # IntAct P25906 4 # InterPro IPR001395 Aldo/ket_red/Kv-b # InterPro IPR023210 NADP_OxRdtase_dom # Organism YDBC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11732 PTHR11732 # PATRIC 32118098 VBIEscCol129921_1469 # PIR A48399 A48399 # Pfam PF00248 Aldo_ket_red # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDBC_ECOLI Putative oxidoreductase YdbC # RefSeq NP_415924 NC_000913.3 # RefSeq WP_000097801 NZ_LN832404.1 # SIMILARITY Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily. {ECO 0000305}. # SUPFAM SSF51430 SSF51430 # eggNOG ENOG4107S5I Bacteria # eggNOG ENOG410XRV3 LUCA BLAST swissprot:YDBC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDBC_ECOLI BioCyc ECOL316407:JW1403-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1403-MONOMER BioCyc EcoCyc:EG11309-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11309-MONOMER BioCyc MetaCyc:EG11309-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11309-MONOMER DIP DIP-11632N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11632N DOI 10.1016/0300-9084(91)90166-X http://dx.doi.org/10.1016/0300-9084(91)90166-X DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.273.40.25974 http://dx.doi.org/10.1074/jbc.273.40.25974 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X62680 http://www.ebi.ac.uk/ena/data/view/X62680 EMBL X97452 http://www.ebi.ac.uk/ena/data/view/X97452 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- EchoBASE EB1285 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1285 EcoGene EG11309 http://www.ecogene.org/geneInfo.php?eg_id=EG11309 EnsemblBacteria AAC74488 http://www.ensemblgenomes.org/id/AAC74488 EnsemblBacteria AAC74488 http://www.ensemblgenomes.org/id/AAC74488 EnsemblBacteria BAA15021 http://www.ensemblgenomes.org/id/BAA15021 EnsemblBacteria BAA15021 http://www.ensemblgenomes.org/id/BAA15021 EnsemblBacteria BAA15021 http://www.ensemblgenomes.org/id/BAA15021 EnsemblBacteria b1406 http://www.ensemblgenomes.org/id/b1406 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 Gene3D 3.20.20.100 http://www.cathdb.info/version/latest/superfamily/3.20.20.100 GeneID 945980 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945980 HOGENOM HOG000250284 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000250284&db=HOGENOM6 InParanoid P25906 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P25906 IntAct P25906 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P25906* IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR001395 http://www.ebi.ac.uk/interpro/entry/IPR001395 InterPro IPR023210 http://www.ebi.ac.uk/interpro/entry/IPR023210 KEGG_Gene ecj:JW1403 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1403 KEGG_Gene eco:b1406 http://www.genome.jp/dbget-bin/www_bget?eco:b1406 OMA VNLRVMF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VNLRVMF PANTHER PTHR11732 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11732 PSORT swissprot:YDBC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDBC_ECOLI PSORT-B swissprot:YDBC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDBC_ECOLI PSORT2 swissprot:YDBC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDBC_ECOLI Pfam PF00248 http://pfam.xfam.org/family/PF00248 Phobius swissprot:YDBC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDBC_ECOLI PhylomeDB P25906 http://phylomedb.org/?seqid=P25906 ProteinModelPortal P25906 http://www.proteinmodelportal.org/query/uniprot/P25906 PubMed 1665988 http://www.ncbi.nlm.nih.gov/pubmed/1665988 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9748275 http://www.ncbi.nlm.nih.gov/pubmed/9748275 RefSeq NP_415924 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415924 RefSeq WP_000097801 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000097801 STRING 511145.b1406 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1406&targetmode=cogs SUPFAM SSF51430 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51430 SWISS-2DPAGE P25906 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P25906 UniProtKB YDBC_ECOLI http://www.uniprot.org/uniprot/YDBC_ECOLI UniProtKB-AC P25906 http://www.uniprot.org/uniprot/P25906 charge swissprot:YDBC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDBC_ECOLI eggNOG ENOG4107S5I http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107S5I eggNOG ENOG410XRV3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRV3 epestfind swissprot:YDBC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDBC_ECOLI garnier swissprot:YDBC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDBC_ECOLI helixturnhelix swissprot:YDBC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDBC_ECOLI hmoment swissprot:YDBC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDBC_ECOLI iep swissprot:YDBC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDBC_ECOLI inforesidue swissprot:YDBC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDBC_ECOLI octanol swissprot:YDBC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDBC_ECOLI pepcoil swissprot:YDBC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDBC_ECOLI pepdigest swissprot:YDBC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDBC_ECOLI pepinfo swissprot:YDBC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDBC_ECOLI pepnet swissprot:YDBC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDBC_ECOLI pepstats swissprot:YDBC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDBC_ECOLI pepwheel swissprot:YDBC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDBC_ECOLI pepwindow swissprot:YDBC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDBC_ECOLI sigcleave swissprot:YDBC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDBC_ECOLI ## Database ID URL or Descriptions # BioGrid 4261820 8 # EcoGene EG12016 yohC # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006950 response to stress # IntAct P0AD17 2 # InterPro IPR009698 DUF1282 # Organism YOHC_ECOLI Escherichia coli (strain K12) # PATRIC 32119613 VBIEscCol129921_2217 # Pfam PF06930 DUF1282 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YOHC_ECOLI Inner membrane protein YohC # RefSeq NP_416639 NC_000913.3 # RefSeq WP_001295454 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA60497.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SUBCELLULAR LOCATION YOHC_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG ENOG41069YE Bacteria # eggNOG ENOG4111H2T LUCA BLAST swissprot:YOHC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YOHC_ECOLI BioCyc ECOL316407:JW5356-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5356-MONOMER BioCyc EcoCyc:EG12016-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12016-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1953 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1953 EcoGene EG12016 http://www.ecogene.org/geneInfo.php?eg_id=EG12016 EnsemblBacteria AAC75196 http://www.ensemblgenomes.org/id/AAC75196 EnsemblBacteria AAC75196 http://www.ensemblgenomes.org/id/AAC75196 EnsemblBacteria BAE76612 http://www.ensemblgenomes.org/id/BAE76612 EnsemblBacteria BAE76612 http://www.ensemblgenomes.org/id/BAE76612 EnsemblBacteria BAE76612 http://www.ensemblgenomes.org/id/BAE76612 EnsemblBacteria b2135 http://www.ensemblgenomes.org/id/b2135 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 946666 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946666 HOGENOM HOG000293849 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000293849&db=HOGENOM6 InParanoid P0AD17 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AD17 IntAct P0AD17 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AD17* InterPro IPR009698 http://www.ebi.ac.uk/interpro/entry/IPR009698 KEGG_Gene ecj:JW5356 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5356 KEGG_Gene eco:b2135 http://www.genome.jp/dbget-bin/www_bget?eco:b2135 OMA HPKEEWH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HPKEEWH PSORT swissprot:YOHC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YOHC_ECOLI PSORT-B swissprot:YOHC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YOHC_ECOLI PSORT2 swissprot:YOHC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YOHC_ECOLI Pfam PF06930 http://pfam.xfam.org/family/PF06930 Phobius swissprot:YOHC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YOHC_ECOLI PhylomeDB P0AD17 http://phylomedb.org/?seqid=P0AD17 ProteinModelPortal P0AD17 http://www.proteinmodelportal.org/query/uniprot/P0AD17 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416639 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416639 RefSeq WP_001295454 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295454 STRING 511145.b2135 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2135&targetmode=cogs UniProtKB YOHC_ECOLI http://www.uniprot.org/uniprot/YOHC_ECOLI UniProtKB-AC P0AD17 http://www.uniprot.org/uniprot/P0AD17 charge swissprot:YOHC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YOHC_ECOLI eggNOG ENOG41069YE http://eggnogapi.embl.de/nog_data/html/tree/ENOG41069YE eggNOG ENOG4111H2T http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111H2T epestfind swissprot:YOHC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YOHC_ECOLI garnier swissprot:YOHC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YOHC_ECOLI helixturnhelix swissprot:YOHC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YOHC_ECOLI hmoment swissprot:YOHC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YOHC_ECOLI iep swissprot:YOHC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YOHC_ECOLI inforesidue swissprot:YOHC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YOHC_ECOLI octanol swissprot:YOHC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YOHC_ECOLI pepcoil swissprot:YOHC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YOHC_ECOLI pepdigest swissprot:YOHC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YOHC_ECOLI pepinfo swissprot:YOHC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YOHC_ECOLI pepnet swissprot:YOHC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YOHC_ECOLI pepstats swissprot:YOHC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YOHC_ECOLI pepwheel swissprot:YOHC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YOHC_ECOLI pepwindow swissprot:YOHC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YOHC_ECOLI sigcleave swissprot:YOHC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YOHC_ECOLI ## Database ID URL or Descriptions # AltName PHOQ_ECOLI Sensor histidine protein kinase/phosphatase PhoQ # BIOPHYSICOCHEMICAL PROPERTIES PHOQ_ECOLI Kinetic parameters KM=20.93 uM for ATP (at 22 degrees Celsius and pH 8, in the presence of 50 mM KCl and 1 mM MgCl(2)) {ECO 0000269|PubMed 11493605, ECO 0000269|PubMed 12670981}; KM=55 uM for ATP (at 22 degrees Celsius and pH 8, in the presence of 25 mM KCl and 0.4 mM MgCl(2)) {ECO 0000269|PubMed 11493605, ECO 0000269|PubMed 12670981}; # BRENDA 2.7.13 2026 # CATALYTIC ACTIVITY PHOQ_ECOLI ATP + protein L-histidine = ADP + protein N- phospho-L-histidine. # ENZYME REGULATION PHOQ_ECOLI Acetyl-CoA acts as a non-competitive inhibitor of the PhoQ autokinase activity. Feedback inhibited by MgrB, which seems to bind PhoQ, altering its activity and that of downstream effector PhoP. {ECO 0000269|PubMed 12670981, ECO 0000269|PubMed 20041203, ECO 0000269|PubMed 22267510}. # EcoGene EG10732 phoQ # FUNCTION PHOQ_ECOLI Member of the two-component regulatory system PhoP/PhoQ involved in adaptation to low Mg(2+) environments and the control of acid resistance genes. In low periplasmic Mg(2+), PhoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), acts as a protein phosphatase that dephosphorylates phospho-PhoP, resulting in the repression of PAG and may lead to expression of some PRG (By similarity). PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing (deletion of dsbA/dsbB, or treatment with dithiothreitol). MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway; the 2 periplasmic Cys residues of MgrB are required for its action on PhoQ, which then acts on PhoP. Mediates magnesium influx to the cytosol by activation of mgtA. Promotes expression of the two-component regulatory system rstA/rstB and transcription of the hemL, mgrB, nagA, slyB, vboR and yrbL genes. {ECO 0000250, ECO 0000269|PubMed 10464230}. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0000155 phosphorelay sensor kinase activity; IMP:EcoCyc. # GO_function GO:0004721 phosphoprotein phosphatase activity; IEA:UniProtKB-KW. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0046872 metal ion binding; IMP:EcoCyc. # GO_process GO:0000160 phosphorelay signal transduction system; IDA:EcoCyc. # GO_process GO:0010350 cellular response to magnesium starvation; IMP:EcoCyc. # GO_process GO:0046777 protein autophosphorylation; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005622 intracellular # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0007165 signal transduction # Gene3D 3.30.565.10 -; 1. # INDUCTION PHOQ_ECOLI The phoP/phoQ operon is positively autoregulated by both PhoP and PhoQ in a Mg(2+)-dependent manner, inhibited at high Mg(2+) concentrations (PubMed 10464230). Induced by dsbA disruption and dithiothreitol (PubMed 22267510). {ECO 0000269|PubMed 10464230, ECO 0000269|PubMed 22267510}. # InterPro IPR003594 HATPase_C # InterPro IPR003660 HAMP_dom # InterPro IPR003661 HisK_dim/P # InterPro IPR004358 Sig_transdc_His_kin-like_C # InterPro IPR005467 His_kinase_dom # InterPro IPR015014 PhoQ_Sensor # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01001 Protein kinases # KEGG_Brite ko02022 M00444 PhoQ-PhoP (magnesium transport) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # MISCELLANEOUS PHOQ_ECOLI There is a close linkage between the PhoP/PhoQ and Rcs signaling systems, and both signaling systems respond to certain external divalent cations (zinc and magnesium). # MISCELLANEOUS PHOQ_ECOLI Two-component regulatory system EvgA/EvgS interacts with PhoP/PhoQ via signal transduction mediated by phospho-EvgA. # Organism PHOQ_ECOLI Escherichia coli (strain K12) # PATRIC 32117507 VBIEscCol129921_1176 # PDB 1ID0 X-ray; 1.60 A; A=335-486 # PDB 3BQ8 X-ray; 2.50 A; A/B=43-190 # PDB 3BQA X-ray; 2.00 A; A/B=43-190 # PIR B41966 B41966 # PRINTS PR00344 BCTRLSENSOR # PROSITE PS50109 HIS_KIN # PROSITE PS50885 HAMP # Pfam PF00672 HAMP # Pfam PF02518 HATPase_c # Pfam PF08918 PhoQ_Sensor # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PHOQ_ECOLI Sensor protein PhoQ # RefSeq NP_415647 NC_000913.3 # RefSeq WP_000735412 NZ_LN832404.1 # SIMILARITY Contains 1 HAMP domain. {ECO:0000255|PROSITE- ProRule PRU00102}. # SIMILARITY Contains 1 histidine kinase domain. {ECO:0000255|PROSITE-ProRule PRU00107}. # SMART SM00387 HATPase_c # SUBCELLULAR LOCATION PHOQ_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # SUBUNIT PHOQ_ECOLI Homodimer; probably dimerizes via the cytoplasmic domain (Probable). Probably interacts with MgrB in the periplasm, altering its activity and that of downstream effector PhoP. {ECO 0000269|PubMed 11493605, ECO 0000269|PubMed 15126461, ECO 0000269|PubMed 18348979, ECO 0000305}. # SUPFAM SSF47384 SSF47384 # SUPFAM SSF55874 SSF55874 # eggNOG COG0642 LUCA # eggNOG ENOG4105IFJ Bacteria BLAST swissprot:PHOQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PHOQ_ECOLI BioCyc ECOL316407:JW1115-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1115-MONOMER BioCyc EcoCyc:PHOQ-MONOMER http://biocyc.org/getid?id=EcoCyc:PHOQ-MONOMER COG COG0642 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0642 DIP DIP-10501N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10501N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0408238102 http://dx.doi.org/10.1073/pnas.0408238102 DOI 10.1073/pnas.1003166107 http://dx.doi.org/10.1073/pnas.1003166107 DOI 10.1074/jbc.271.43.26630 http://dx.doi.org/10.1074/jbc.271.43.26630 DOI 10.1074/jbc.M106080200 http://dx.doi.org/10.1074/jbc.M106080200 DOI 10.1074/jbc.M710592200 http://dx.doi.org/10.1074/jbc.M710592200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.06055-11 http://dx.doi.org/10.1128/JB.06055-11 DOI 10.1128/JB.184.19.5468-5478.2002 http://dx.doi.org/10.1128/JB.184.19.5468-5478.2002 DOI 10.1128/JB.185.13.3696-3702.2003 http://dx.doi.org/10.1128/JB.185.13.3696-3702.2003 DOI 10.1128/JB.185.19.5735-5746.2003 http://dx.doi.org/10.1128/JB.185.19.5735-5746.2003 DOI 10.1128/JB.185.8.2563-2570.2003 http://dx.doi.org/10.1128/JB.185.8.2563-2570.2003 DOI 10.1128/JB.186.10.3006-3014.2004 http://dx.doi.org/10.1128/JB.186.10.3006-3014.2004 DOI 10.1271/bbb.69.1281 http://dx.doi.org/10.1271/bbb.69.1281 DOI 10.1371/journal.pgen.1000788 http://dx.doi.org/10.1371/journal.pgen.1000788 EC_number EC:2.7.13.3 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.13.3 EC_number EC:3.1.3.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D90393 http://www.ebi.ac.uk/ena/data/view/D90393 EMBL M81433 http://www.ebi.ac.uk/ena/data/view/M81433 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.13.3 http://enzyme.expasy.org/EC/2.7.13.3 ENZYME 3.1.3.- http://enzyme.expasy.org/EC/3.1.3.- EchoBASE EB0725 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0725 EcoGene EG10732 http://www.ecogene.org/geneInfo.php?eg_id=EG10732 EnsemblBacteria AAC74213 http://www.ensemblgenomes.org/id/AAC74213 EnsemblBacteria AAC74213 http://www.ensemblgenomes.org/id/AAC74213 EnsemblBacteria BAA35951 http://www.ensemblgenomes.org/id/BAA35951 EnsemblBacteria BAA35951 http://www.ensemblgenomes.org/id/BAA35951 EnsemblBacteria BAA35951 http://www.ensemblgenomes.org/id/BAA35951 EnsemblBacteria b1129 http://www.ensemblgenomes.org/id/b1129 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0000155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000155 GO_function GO:0004721 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004721 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0010350 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010350 GO_process GO:0046777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046777 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 Gene3D 3.30.565.10 http://www.cathdb.info/version/latest/superfamily/3.30.565.10 GeneID 946326 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946326 HOGENOM HOG000274481 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000274481&db=HOGENOM6 InParanoid P23837 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23837 IntAct P23837 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P23837* IntEnz 2.7.13.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.13.3 IntEnz 3.1.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3 InterPro IPR003594 http://www.ebi.ac.uk/interpro/entry/IPR003594 InterPro IPR003660 http://www.ebi.ac.uk/interpro/entry/IPR003660 InterPro IPR003661 http://www.ebi.ac.uk/interpro/entry/IPR003661 InterPro IPR004358 http://www.ebi.ac.uk/interpro/entry/IPR004358 InterPro IPR005467 http://www.ebi.ac.uk/interpro/entry/IPR005467 InterPro IPR015014 http://www.ebi.ac.uk/interpro/entry/IPR015014 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01001 http://www.genome.jp/dbget-bin/www_bget?ko01001 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW1115 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1115 KEGG_Gene eco:b1129 http://www.genome.jp/dbget-bin/www_bget?eco:b1129 KEGG_Orthology KO:K07637 http://www.genome.jp/dbget-bin/www_bget?KO:K07637 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA TLVFIYD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TLVFIYD PDB 1ID0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ID0 PDB 3BQ8 http://www.ebi.ac.uk/pdbe-srv/view/entry/3BQ8 PDB 3BQA http://www.ebi.ac.uk/pdbe-srv/view/entry/3BQA PDBsum 1ID0 http://www.ebi.ac.uk/pdbsum/1ID0 PDBsum 3BQ8 http://www.ebi.ac.uk/pdbsum/3BQ8 PDBsum 3BQA http://www.ebi.ac.uk/pdbsum/3BQA PRINTS PR00344 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00344 PROSITE PS50109 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50109 PROSITE PS50885 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50885 PSORT swissprot:PHOQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PHOQ_ECOLI PSORT-B swissprot:PHOQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PHOQ_ECOLI PSORT2 swissprot:PHOQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PHOQ_ECOLI Pfam PF00672 http://pfam.xfam.org/family/PF00672 Pfam PF02518 http://pfam.xfam.org/family/PF02518 Pfam PF08918 http://pfam.xfam.org/family/PF08918 Phobius swissprot:PHOQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PHOQ_ECOLI PhylomeDB P23837 http://phylomedb.org/?seqid=P23837 ProteinModelPortal P23837 http://www.proteinmodelportal.org/query/uniprot/P23837 PubMed 10464230 http://www.ncbi.nlm.nih.gov/pubmed/10464230 PubMed 11493605 http://www.ncbi.nlm.nih.gov/pubmed/11493605 PubMed 12218035 http://www.ncbi.nlm.nih.gov/pubmed/12218035 PubMed 12670981 http://www.ncbi.nlm.nih.gov/pubmed/12670981 PubMed 12813061 http://www.ncbi.nlm.nih.gov/pubmed/12813061 PubMed 13129944 http://www.ncbi.nlm.nih.gov/pubmed/13129944 PubMed 15126461 http://www.ncbi.nlm.nih.gov/pubmed/15126461 PubMed 1530848 http://www.ncbi.nlm.nih.gov/pubmed/1530848 PubMed 15703297 http://www.ncbi.nlm.nih.gov/pubmed/15703297 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16041131 http://www.ncbi.nlm.nih.gov/pubmed/16041131 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1729240 http://www.ncbi.nlm.nih.gov/pubmed/1729240 PubMed 18348979 http://www.ncbi.nlm.nih.gov/pubmed/18348979 PubMed 20041203 http://www.ncbi.nlm.nih.gov/pubmed/20041203 PubMed 20404199 http://www.ncbi.nlm.nih.gov/pubmed/20404199 PubMed 22267510 http://www.ncbi.nlm.nih.gov/pubmed/22267510 PubMed 8900137 http://www.ncbi.nlm.nih.gov/pubmed/8900137 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415647 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415647 RefSeq WP_000735412 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000735412 SMART SM00387 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00387 SMR P23837 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P23837 STRING 511145.b1129 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1129&targetmode=cogs STRING COG0642 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0642&targetmode=cogs SUPFAM SSF47384 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47384 SUPFAM SSF55874 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55874 UniProtKB PHOQ_ECOLI http://www.uniprot.org/uniprot/PHOQ_ECOLI UniProtKB-AC P23837 http://www.uniprot.org/uniprot/P23837 charge swissprot:PHOQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PHOQ_ECOLI eggNOG COG0642 http://eggnogapi.embl.de/nog_data/html/tree/COG0642 eggNOG ENOG4105IFJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105IFJ epestfind swissprot:PHOQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PHOQ_ECOLI garnier swissprot:PHOQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PHOQ_ECOLI helixturnhelix swissprot:PHOQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PHOQ_ECOLI hmoment swissprot:PHOQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PHOQ_ECOLI iep swissprot:PHOQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PHOQ_ECOLI inforesidue swissprot:PHOQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PHOQ_ECOLI octanol swissprot:PHOQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PHOQ_ECOLI pepcoil swissprot:PHOQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PHOQ_ECOLI pepdigest swissprot:PHOQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PHOQ_ECOLI pepinfo swissprot:PHOQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PHOQ_ECOLI pepnet swissprot:PHOQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PHOQ_ECOLI pepstats swissprot:PHOQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PHOQ_ECOLI pepwheel swissprot:PHOQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PHOQ_ECOLI pepwindow swissprot:PHOQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PHOQ_ECOLI sigcleave swissprot:PHOQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PHOQ_ECOLI ## Database ID URL or Descriptions # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG14357 ymdE # GO_function GO:0016740 transferase activity; IEA:InterPro. # GO_process GO:0008152 metabolic process; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0008150 biological_process # Gene3D 3.40.366.10 -; 1. # IntAct Q7DFV4 5 # InterPro IPR001227 Ac_transferase_dom # InterPro IPR016035 Acyl_Trfase/lysoPLipase # Organism YMDE_ECOLI Escherichia coli (strain K12) # PIR B64845 B64845 # Proteomes UP000000625 Chromosome # RecName YMDE_ECOLI Putative uncharacterized protein YmdE # RefSeq WP_000389396 NZ_LN832404.1 # SUPFAM SSF52151 SSF52151 BLAST swissprot:YMDE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YMDE_ECOLI BioCyc EcoCyc:G6535-MONOMER http://biocyc.org/getid?id=EcoCyc:G6535-MONOMER DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14357 http://www.ecogene.org/geneInfo.php?eg_id=EG14357 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016740 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016740 GO_process GO:0008152 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008152 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.366.10 http://www.cathdb.info/version/latest/superfamily/3.40.366.10 HOGENOM HOG000009408 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009408&db=HOGENOM6 IntAct Q7DFV4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q7DFV4* InterPro IPR001227 http://www.ebi.ac.uk/interpro/entry/IPR001227 InterPro IPR016035 http://www.ebi.ac.uk/interpro/entry/IPR016035 PSORT swissprot:YMDE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YMDE_ECOLI PSORT-B swissprot:YMDE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YMDE_ECOLI PSORT2 swissprot:YMDE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YMDE_ECOLI Phobius swissprot:YMDE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YMDE_ECOLI ProteinModelPortal Q7DFV4 http://www.proteinmodelportal.org/query/uniprot/Q7DFV4 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000389396 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000389396 SUPFAM SSF52151 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52151 UniProtKB YMDE_ECOLI http://www.uniprot.org/uniprot/YMDE_ECOLI UniProtKB-AC Q7DFV4 http://www.uniprot.org/uniprot/Q7DFV4 charge swissprot:YMDE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YMDE_ECOLI epestfind swissprot:YMDE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YMDE_ECOLI garnier swissprot:YMDE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YMDE_ECOLI helixturnhelix swissprot:YMDE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YMDE_ECOLI hmoment swissprot:YMDE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YMDE_ECOLI iep swissprot:YMDE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YMDE_ECOLI inforesidue swissprot:YMDE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YMDE_ECOLI octanol swissprot:YMDE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YMDE_ECOLI pepcoil swissprot:YMDE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YMDE_ECOLI pepdigest swissprot:YMDE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YMDE_ECOLI pepinfo swissprot:YMDE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YMDE_ECOLI pepnet swissprot:YMDE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YMDE_ECOLI pepstats swissprot:YMDE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YMDE_ECOLI pepwheel swissprot:YMDE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YMDE_ECOLI pepwindow swissprot:YMDE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YMDE_ECOLI sigcleave swissprot:YMDE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YMDE_ECOLI ## Database ID URL or Descriptions # BioGrid 4261954 10 # EcoGene EG14115 yfcL # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # IntAct P64540 8 # InterPro IPR014987 UPF_YfcL # Organism YFCL_ECOLI Escherichia coli (strain K12) # PATRIC 32120023 VBIEscCol129921_2421 # PIR C65005 C65005 # Pfam PF08891 YfcL # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFCL_ECOLI Uncharacterized protein YfcL # RefSeq NP_416828 NC_000913.3 # RefSeq WP_000559764 NZ_LN832404.1 # eggNOG ENOG4105MH2 Bacteria # eggNOG ENOG4111TYU LUCA BLAST swissprot:YFCL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFCL_ECOLI BioCyc ECOL316407:JW2322-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2322-MONOMER BioCyc EcoCyc:G7200-MONOMER http://biocyc.org/getid?id=EcoCyc:G7200-MONOMER DIP DIP-48102N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48102N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3868 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3868 EcoGene EG14115 http://www.ecogene.org/geneInfo.php?eg_id=EG14115 EnsemblBacteria AAC75385 http://www.ensemblgenomes.org/id/AAC75385 EnsemblBacteria AAC75385 http://www.ensemblgenomes.org/id/AAC75385 EnsemblBacteria BAE76688 http://www.ensemblgenomes.org/id/BAE76688 EnsemblBacteria BAE76688 http://www.ensemblgenomes.org/id/BAE76688 EnsemblBacteria BAE76688 http://www.ensemblgenomes.org/id/BAE76688 EnsemblBacteria b2325 http://www.ensemblgenomes.org/id/b2325 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GeneID 946804 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946804 HOGENOM HOG000276558 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276558&db=HOGENOM6 IntAct P64540 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P64540* InterPro IPR014987 http://www.ebi.ac.uk/interpro/entry/IPR014987 KEGG_Gene ecj:JW2322 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2322 KEGG_Gene eco:b2325 http://www.genome.jp/dbget-bin/www_bget?eco:b2325 OMA LVLGMWD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LVLGMWD PSORT swissprot:YFCL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFCL_ECOLI PSORT-B swissprot:YFCL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFCL_ECOLI PSORT2 swissprot:YFCL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFCL_ECOLI Pfam PF08891 http://pfam.xfam.org/family/PF08891 Phobius swissprot:YFCL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFCL_ECOLI ProteinModelPortal P64540 http://www.proteinmodelportal.org/query/uniprot/P64540 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416828 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416828 RefSeq WP_000559764 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000559764 STRING 511145.b2325 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2325&targetmode=cogs UniProtKB YFCL_ECOLI http://www.uniprot.org/uniprot/YFCL_ECOLI UniProtKB-AC P64540 http://www.uniprot.org/uniprot/P64540 charge swissprot:YFCL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFCL_ECOLI eggNOG ENOG4105MH2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105MH2 eggNOG ENOG4111TYU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111TYU epestfind swissprot:YFCL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFCL_ECOLI garnier swissprot:YFCL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFCL_ECOLI helixturnhelix swissprot:YFCL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFCL_ECOLI hmoment swissprot:YFCL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFCL_ECOLI iep swissprot:YFCL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFCL_ECOLI inforesidue swissprot:YFCL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFCL_ECOLI octanol swissprot:YFCL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFCL_ECOLI pepcoil swissprot:YFCL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFCL_ECOLI pepdigest swissprot:YFCL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFCL_ECOLI pepinfo swissprot:YFCL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFCL_ECOLI pepnet swissprot:YFCL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFCL_ECOLI pepstats swissprot:YFCL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFCL_ECOLI pepwheel swissprot:YFCL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFCL_ECOLI pepwindow swissprot:YFCL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFCL_ECOLI sigcleave swissprot:YFCL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFCL_ECOLI ## Database ID URL or Descriptions # BioGrid 4261435 13 # CDD cd03034 ArsC_ArsC # EcoGene EG14200 yfgD # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008794 arsenate reductase (glutaredoxin) activity; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # Gene3D 3.40.30.10 -; 1. # IntAct P76569 12 # InterPro IPR006659 Arsenate_reductase # InterPro IPR006660 Arsenate_reductase-like # InterPro IPR012336 Thioredoxin-like_fold # KEGG_Brite ko01000 Enzymes # Organism YFGD_ECOLI Escherichia coli (strain K12) # PATRIC 32120377 VBIEscCol129921_2591 # PIR F65025 F65025 # PROSITE PS51353 ARSC # Pfam PF03960 ArsC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFGD_ECOLI Uncharacterized protein YfgD # RefSeq NP_416990 NC_000913.3 # RefSeq WP_000166446 NZ_LN832404.1 # SIMILARITY Belongs to the ArsC family. {ECO 0000305}. # SUPFAM SSF52833 SSF52833 # TIGRFAMs TIGR00014 arsC # eggNOG COG1393 LUCA # eggNOG ENOG4105K89 Bacteria BLAST swissprot:YFGD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFGD_ECOLI BioCyc ECOL316407:JW2480-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2480-MONOMER BioCyc EcoCyc:G7312-MONOMER http://biocyc.org/getid?id=EcoCyc:G7312-MONOMER COG COG1393 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1393 DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3952 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3952 EcoGene EG14200 http://www.ecogene.org/geneInfo.php?eg_id=EG14200 EnsemblBacteria AAC75548 http://www.ensemblgenomes.org/id/AAC75548 EnsemblBacteria AAC75548 http://www.ensemblgenomes.org/id/AAC75548 EnsemblBacteria BAA16383 http://www.ensemblgenomes.org/id/BAA16383 EnsemblBacteria BAA16383 http://www.ensemblgenomes.org/id/BAA16383 EnsemblBacteria BAA16383 http://www.ensemblgenomes.org/id/BAA16383 EnsemblBacteria b2495 http://www.ensemblgenomes.org/id/b2495 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008794 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008794 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 Gene3D 3.40.30.10 http://www.cathdb.info/version/latest/superfamily/3.40.30.10 GeneID 946974 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946974 HOGENOM HOG000059717 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000059717&db=HOGENOM6 InParanoid P76569 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76569 IntAct P76569 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76569* InterPro IPR006659 http://www.ebi.ac.uk/interpro/entry/IPR006659 InterPro IPR006660 http://www.ebi.ac.uk/interpro/entry/IPR006660 InterPro IPR012336 http://www.ebi.ac.uk/interpro/entry/IPR012336 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2480 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2480 KEGG_Gene eco:b2495 http://www.genome.jp/dbget-bin/www_bget?eco:b2495 KEGG_Orthology KO:K00537 http://www.genome.jp/dbget-bin/www_bget?KO:K00537 OMA ETQIYHN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ETQIYHN PROSITE PS51353 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51353 PSORT swissprot:YFGD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFGD_ECOLI PSORT-B swissprot:YFGD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFGD_ECOLI PSORT2 swissprot:YFGD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFGD_ECOLI Pfam PF03960 http://pfam.xfam.org/family/PF03960 Phobius swissprot:YFGD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFGD_ECOLI PhylomeDB P76569 http://phylomedb.org/?seqid=P76569 ProteinModelPortal P76569 http://www.proteinmodelportal.org/query/uniprot/P76569 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416990 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416990 RefSeq WP_000166446 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000166446 SMR P76569 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76569 STRING 511145.b2495 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2495&targetmode=cogs STRING COG1393 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1393&targetmode=cogs SUPFAM SSF52833 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52833 TIGRFAMs TIGR00014 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00014 UniProtKB YFGD_ECOLI http://www.uniprot.org/uniprot/YFGD_ECOLI UniProtKB-AC P76569 http://www.uniprot.org/uniprot/P76569 charge swissprot:YFGD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFGD_ECOLI eggNOG COG1393 http://eggnogapi.embl.de/nog_data/html/tree/COG1393 eggNOG ENOG4105K89 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K89 epestfind swissprot:YFGD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFGD_ECOLI garnier swissprot:YFGD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFGD_ECOLI helixturnhelix swissprot:YFGD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFGD_ECOLI hmoment swissprot:YFGD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFGD_ECOLI iep swissprot:YFGD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFGD_ECOLI inforesidue swissprot:YFGD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFGD_ECOLI octanol swissprot:YFGD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFGD_ECOLI pepcoil swissprot:YFGD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFGD_ECOLI pepdigest swissprot:YFGD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFGD_ECOLI pepinfo swissprot:YFGD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFGD_ECOLI pepnet swissprot:YFGD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFGD_ECOLI pepstats swissprot:YFGD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFGD_ECOLI pepwheel swissprot:YFGD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFGD_ECOLI pepwindow swissprot:YFGD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFGD_ECOLI sigcleave swissprot:YFGD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFGD_ECOLI ## Database ID URL or Descriptions # BioGrid 4262495 12 # EcoGene EG10540 livK # FUNCTION LIVK_ECOLI This protein is a component of the leucine-specific transport system, which is one of the two periplasmic binding protein-dependent transport systems of the high-affinity transport of the branched-chain amino acids in E.coli. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0015190 L-leucine transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0015820 leucine transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # IntAct P04816 3 # InterPro IPR000709 Leu_Ile_Val-bd # InterPro IPR028081 Leu-bd # InterPro IPR028082 Peripla_BP_I # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00237 Branched-chain amino acid transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism LIVK_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30483:SF16 PTHR30483:SF16 # PATRIC 32122358 VBIEscCol129921_3556 # PDB 1USG X-ray; 1.53 A; A=24-369 # PDB 1USI X-ray; 1.80 A; A/C=24-369 # PDB 1USK X-ray; 2.00 A; A/B/C/D=24-369 # PDB 2LBP X-ray; 2.40 A; A=24-369 # PIR E65142 BLECL # PRINTS PR00337 LEUILEVALBP # Pfam PF13458 Peripla_BP_6 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LIVK_ECOLI Leucine-specific-binding protein # RefSeq NP_417915 NC_000913.3 # RefSeq WP_000827696 NZ_LN832404.1 # SIMILARITY Belongs to the leucine-binding protein family. {ECO 0000305}. # SUBCELLULAR LOCATION LIVK_ECOLI Periplasm. # SUPFAM SSF53822 SSF53822 # TCDB 3.A.1.4 the atp-binding cassette (abc) superfamily # eggNOG COG0683 LUCA # eggNOG ENOG4105CP9 Bacteria BLAST swissprot:LIVK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LIVK_ECOLI BioCyc ECOL316407:JW3423-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3423-MONOMER BioCyc EcoCyc:LIVK-MONOMER http://biocyc.org/getid?id=EcoCyc:LIVK-MONOMER BioCyc MetaCyc:LIVK-MONOMER http://biocyc.org/getid?id=MetaCyc:LIVK-MONOMER COG COG0683 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0683 DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1002/jcb.240290305 http://dx.doi.org/10.1002/jcb.240290305 DOI 10.1016/0022-2836(89)90532-9 http://dx.doi.org/10.1016/0022-2836(89)90532-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.77.4.2005 http://dx.doi.org/10.1073/pnas.77.4.2005 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J05516 http://www.ebi.ac.uk/ena/data/view/J05516 EMBL M29378 http://www.ebi.ac.uk/ena/data/view/M29378 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00301 http://www.ebi.ac.uk/ena/data/view/V00301 EchoBASE EB0535 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0535 EcoGene EG10540 http://www.ecogene.org/geneInfo.php?eg_id=EG10540 EnsemblBacteria AAC76483 http://www.ensemblgenomes.org/id/AAC76483 EnsemblBacteria AAC76483 http://www.ensemblgenomes.org/id/AAC76483 EnsemblBacteria BAE77835 http://www.ensemblgenomes.org/id/BAE77835 EnsemblBacteria BAE77835 http://www.ensemblgenomes.org/id/BAE77835 EnsemblBacteria BAE77835 http://www.ensemblgenomes.org/id/BAE77835 EnsemblBacteria b3458 http://www.ensemblgenomes.org/id/b3458 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0015190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015190 GO_process GO:0015820 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015820 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 947964 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947964 HOGENOM HOG000130989 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000130989&db=HOGENOM6 InParanoid P04816 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P04816 IntAct P04816 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P04816* InterPro IPR000709 http://www.ebi.ac.uk/interpro/entry/IPR000709 InterPro IPR028081 http://www.ebi.ac.uk/interpro/entry/IPR028081 InterPro IPR028082 http://www.ebi.ac.uk/interpro/entry/IPR028082 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3423 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3423 KEGG_Gene eco:b3458 http://www.genome.jp/dbget-bin/www_bget?eco:b3458 KEGG_Orthology KO:K01999 http://www.genome.jp/dbget-bin/www_bget?KO:K01999 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA MITPGAT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MITPGAT PANTHER PTHR30483:SF16 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30483:SF16 PDB 1USG http://www.ebi.ac.uk/pdbe-srv/view/entry/1USG PDB 1USI http://www.ebi.ac.uk/pdbe-srv/view/entry/1USI PDB 1USK http://www.ebi.ac.uk/pdbe-srv/view/entry/1USK PDB 2LBP http://www.ebi.ac.uk/pdbe-srv/view/entry/2LBP PDBsum 1USG http://www.ebi.ac.uk/pdbsum/1USG PDBsum 1USI http://www.ebi.ac.uk/pdbsum/1USI PDBsum 1USK http://www.ebi.ac.uk/pdbsum/1USK PDBsum 2LBP http://www.ebi.ac.uk/pdbsum/2LBP PRINTS PR00337 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00337 PSORT swissprot:LIVK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LIVK_ECOLI PSORT-B swissprot:LIVK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LIVK_ECOLI PSORT2 swissprot:LIVK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LIVK_ECOLI Pfam PF13458 http://pfam.xfam.org/family/PF13458 Phobius swissprot:LIVK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LIVK_ECOLI PhylomeDB P04816 http://phylomedb.org/?seqid=P04816 ProteinModelPortal P04816 http://www.proteinmodelportal.org/query/uniprot/P04816 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2195019 http://www.ncbi.nlm.nih.gov/pubmed/2195019 PubMed 2649683 http://www.ncbi.nlm.nih.gov/pubmed/2649683 PubMed 3891753 http://www.ncbi.nlm.nih.gov/pubmed/3891753 PubMed 4077929 http://www.ncbi.nlm.nih.gov/pubmed/4077929 PubMed 6990419 http://www.ncbi.nlm.nih.gov/pubmed/6990419 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_417915 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417915 RefSeq WP_000827696 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000827696 SMR P04816 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P04816 STRING 511145.b3458 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3458&targetmode=cogs STRING COG0683 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0683&targetmode=cogs SUPFAM SSF53822 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822 SWISS-2DPAGE P04816 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P04816 TCDB 3.A.1.4 http://www.tcdb.org/search/result.php?tc=3.A.1.4 UniProtKB LIVK_ECOLI http://www.uniprot.org/uniprot/LIVK_ECOLI UniProtKB-AC P04816 http://www.uniprot.org/uniprot/P04816 charge swissprot:LIVK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LIVK_ECOLI eggNOG COG0683 http://eggnogapi.embl.de/nog_data/html/tree/COG0683 eggNOG ENOG4105CP9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CP9 epestfind swissprot:LIVK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LIVK_ECOLI garnier swissprot:LIVK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LIVK_ECOLI helixturnhelix swissprot:LIVK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LIVK_ECOLI hmoment swissprot:LIVK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LIVK_ECOLI iep swissprot:LIVK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LIVK_ECOLI inforesidue swissprot:LIVK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LIVK_ECOLI octanol swissprot:LIVK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LIVK_ECOLI pepcoil swissprot:LIVK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LIVK_ECOLI pepdigest swissprot:LIVK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LIVK_ECOLI pepinfo swissprot:LIVK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LIVK_ECOLI pepnet swissprot:LIVK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LIVK_ECOLI pepstats swissprot:LIVK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LIVK_ECOLI pepwheel swissprot:LIVK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LIVK_ECOLI pepwindow swissprot:LIVK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LIVK_ECOLI sigcleave swissprot:LIVK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LIVK_ECOLI ## Database ID URL or Descriptions # BioGrid 4262403 11 # EcoGene EG12729 ygjR # GO_function GO:0016491 oxidoreductase activity; IBA:GO_Central. # GO_process GO:0055114 oxidation-reduction process; IBA:GO_Central. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.720 -; 1. # IntAct P42599 10 # InterPro IPR000683 Oxidoreductase_N # InterPro IPR016040 NAD(P)-bd_dom # Organism YGJR_ECOLI Escherichia coli (strain K12) # PATRIC 32121592 VBIEscCol129921_3182 # PIR D65097 D65097 # Pfam PF01408 GFO_IDH_MocA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGJR_ECOLI Uncharacterized oxidoreductase YgjR # RefSeq NP_417558 NC_000913.3 # RefSeq WP_000617698 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA57888.1; Type=Frameshift; Positions=211; Evidence={ECO:0000305}; Sequence=AAA57889.1; Type=Frameshift; Positions=211; Evidence={ECO 0000305}; Sequence=BAE77137.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; # SIMILARITY Belongs to the Gfo/Idh/MocA family. {ECO 0000305}. # SUPFAM SSF51735 SSF51735 # eggNOG COG0673 LUCA # eggNOG ENOG4105EE0 Bacteria BLAST swissprot:YGJR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGJR_ECOLI BioCyc ECOL316407:JW3058-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3058-MONOMER BioCyc EcoCyc:G7606-MONOMER http://biocyc.org/getid?id=EcoCyc:G7606-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- EchoBASE EB2588 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2588 EcoGene EG12729 http://www.ecogene.org/geneInfo.php?eg_id=EG12729 EnsemblBacteria AAC76122 http://www.ensemblgenomes.org/id/AAC76122 EnsemblBacteria AAC76122 http://www.ensemblgenomes.org/id/AAC76122 EnsemblBacteria BAE77137 http://www.ensemblgenomes.org/id/BAE77137 EnsemblBacteria BAE77137 http://www.ensemblgenomes.org/id/BAE77137 EnsemblBacteria BAE77137 http://www.ensemblgenomes.org/id/BAE77137 EnsemblBacteria b3087 http://www.ensemblgenomes.org/id/b3087 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_process GO:0055114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 947600 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947600 HOGENOM HOG000227441 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000227441&db=HOGENOM6 InParanoid P42599 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P42599 IntAct P42599 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P42599* IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR000683 http://www.ebi.ac.uk/interpro/entry/IPR000683 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 KEGG_Gene ecj:JW3058 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3058 KEGG_Gene eco:b3087 http://www.genome.jp/dbget-bin/www_bget?eco:b3087 OMA HRVEYLP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HRVEYLP PSORT swissprot:YGJR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGJR_ECOLI PSORT-B swissprot:YGJR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGJR_ECOLI PSORT2 swissprot:YGJR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGJR_ECOLI Pfam PF01408 http://pfam.xfam.org/family/PF01408 Phobius swissprot:YGJR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGJR_ECOLI PhylomeDB P42599 http://phylomedb.org/?seqid=P42599 ProteinModelPortal P42599 http://www.proteinmodelportal.org/query/uniprot/P42599 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417558 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417558 RefSeq WP_000617698 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000617698 SMR P42599 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P42599 STRING 511145.b3087 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3087&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB YGJR_ECOLI http://www.uniprot.org/uniprot/YGJR_ECOLI UniProtKB-AC P42599 http://www.uniprot.org/uniprot/P42599 charge swissprot:YGJR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGJR_ECOLI eggNOG COG0673 http://eggnogapi.embl.de/nog_data/html/tree/COG0673 eggNOG ENOG4105EE0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EE0 epestfind swissprot:YGJR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGJR_ECOLI garnier swissprot:YGJR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGJR_ECOLI helixturnhelix swissprot:YGJR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGJR_ECOLI hmoment swissprot:YGJR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGJR_ECOLI iep swissprot:YGJR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGJR_ECOLI inforesidue swissprot:YGJR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGJR_ECOLI octanol swissprot:YGJR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGJR_ECOLI pepcoil swissprot:YGJR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGJR_ECOLI pepdigest swissprot:YGJR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGJR_ECOLI pepinfo swissprot:YGJR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGJR_ECOLI pepnet swissprot:YGJR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGJR_ECOLI pepstats swissprot:YGJR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGJR_ECOLI pepwheel swissprot:YGJR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGJR_ECOLI pepwindow swissprot:YGJR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGJR_ECOLI sigcleave swissprot:YGJR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGJR_ECOLI ## Database ID URL or Descriptions # AltName CBTA_ECOLI Toxin YeeV # AltName Toxin CbtA {ECO:0000303|PubMed 21166897} # BioGrid 4261508 8 # DISRUPTION PHENOTYPE No visible phenotype. {ECO:0000269|PubMed 21166897}. # DOMAIN CBTA_ECOLI The N-terminal 15 residues are required for interaction with both FtsZ and MreB, while the C-terminal 63 residues are required for interaction with MreB. {ECO 0000269|PubMed 21166897}. # EcoGene EG13389 cbtA # FUNCTION CBTA_ECOLI Toxic component of a type IV toxin-antitoxin (TA) module. Interacts with cytoskeletal proteins FtsZ and MreB; inhibits FtsZ GTP-dependent polymerization and GTPase activity as well as MreB ATP-dependent polymerization. Binds to both the N- and C-terminus of FtsZ, likely blocking its polymerization. Overexpression results in inhibition of growth in liquid cultures and decrease in colony formation; these effects are overcome by concomitant expression of antitoxin CbeA (YeeU). In other experiments after 6 hours cells are lemon-shaped and by 24 hours those that have not lysed are spherical with diminished polar regions. Toxic effects are neutralized by cognate antitoxin CbeA, although there is no direct interaction between the 2 proteins. {ECO 0000269|PubMed 14594833, ECO 0000269|PubMed 21166897, ECO 0000269|PubMed 22515815}. # GO_function GO:0008092 cytoskeletal protein binding; IDA:EcoCyc. # GO_process GO:0008360 regulation of cell shape; IEA:UniProtKB-KW. # GO_process GO:0012501 programmed cell death; IMP:EcoCyc. # GOslim_function GO:0008092 cytoskeletal protein binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0008219 cell death # IntAct P64524 6 # InterPro IPR009610 CbtA_toxin # Organism CBTA_ECOLI Escherichia coli (strain K12) # PATRIC 32119343 VBIEscCol129921_2081 # PIR D64965 D64965 # Pfam PF06755 CbtA_toxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Cytoskeleton-binding toxin CbtA {ECO:0000303|PubMed 21166897} # RefSeq NP_416509 NC_000913.3 # RefSeq WP_000854814 NZ_LN832404.1 # SIMILARITY Belongs to the CbtA/YkfI/YpjF toxin family. {ECO 0000305}. # SUBUNIT Interacts with FtsZ and MreB. {ECO:0000269|PubMed 21166897}. BLAST swissprot:CBTA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CBTA_ECOLI BioCyc ECOL316407:JW1987-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1987-MONOMER BioCyc EcoCyc:G7085-MONOMER http://biocyc.org/getid?id=EcoCyc:G7085-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2010.07433.x http://dx.doi.org/10.1111/j.1365-2958.2010.07433.x DOI 10.1111/j.1365-2958.2012.08068.x http://dx.doi.org/10.1111/j.1365-2958.2012.08068.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.185.22.6600-6608.2003 http://dx.doi.org/10.1128/JB.185.22.6600-6608.2003 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3170 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3170 EcoGene EG13389 http://www.ecogene.org/geneInfo.php?eg_id=EG13389 EnsemblBacteria AAC75066 http://www.ensemblgenomes.org/id/AAC75066 EnsemblBacteria AAC75066 http://www.ensemblgenomes.org/id/AAC75066 EnsemblBacteria BAE76565 http://www.ensemblgenomes.org/id/BAE76565 EnsemblBacteria BAE76565 http://www.ensemblgenomes.org/id/BAE76565 EnsemblBacteria BAE76565 http://www.ensemblgenomes.org/id/BAE76565 EnsemblBacteria b2005 http://www.ensemblgenomes.org/id/b2005 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008092 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008092 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0012501 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0012501 GOslim_function GO:0008092 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008092 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0008219 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008219 GeneID 946534 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946534 HOGENOM HOG000124769 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000124769&db=HOGENOM6 IntAct P64524 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P64524* InterPro IPR009610 http://www.ebi.ac.uk/interpro/entry/IPR009610 KEGG_Gene ecj:JW1987 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1987 KEGG_Gene eco:b2005 http://www.genome.jp/dbget-bin/www_bget?eco:b2005 PSORT swissprot:CBTA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CBTA_ECOLI PSORT-B swissprot:CBTA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CBTA_ECOLI PSORT2 swissprot:CBTA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CBTA_ECOLI Pfam PF06755 http://pfam.xfam.org/family/PF06755 Phobius swissprot:CBTA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CBTA_ECOLI PhylomeDB P64524 http://phylomedb.org/?seqid=P64524 ProteinModelPortal P64524 http://www.proteinmodelportal.org/query/uniprot/P64524 PubMed 14594833 http://www.ncbi.nlm.nih.gov/pubmed/14594833 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21166897 http://www.ncbi.nlm.nih.gov/pubmed/21166897 PubMed 22515815 http://www.ncbi.nlm.nih.gov/pubmed/22515815 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416509 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416509 RefSeq WP_000854814 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000854814 STRING 511145.b2005 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2005&targetmode=cogs UniProtKB CBTA_ECOLI http://www.uniprot.org/uniprot/CBTA_ECOLI UniProtKB-AC P64524 http://www.uniprot.org/uniprot/P64524 charge swissprot:CBTA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CBTA_ECOLI epestfind swissprot:CBTA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CBTA_ECOLI garnier swissprot:CBTA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CBTA_ECOLI helixturnhelix swissprot:CBTA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CBTA_ECOLI hmoment swissprot:CBTA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CBTA_ECOLI iep swissprot:CBTA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CBTA_ECOLI inforesidue swissprot:CBTA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CBTA_ECOLI octanol swissprot:CBTA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CBTA_ECOLI pepcoil swissprot:CBTA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CBTA_ECOLI pepdigest swissprot:CBTA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CBTA_ECOLI pepinfo swissprot:CBTA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CBTA_ECOLI pepnet swissprot:CBTA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CBTA_ECOLI pepstats swissprot:CBTA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CBTA_ECOLI pepwheel swissprot:CBTA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CBTA_ECOLI pepwindow swissprot:CBTA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CBTA_ECOLI sigcleave swissprot:CBTA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CBTA_ECOLI ## Database ID URL or Descriptions # BioGrid 4263338 7 # EcoGene EG13326 ybiU # Gene3D 2.60.120.330 -; 1. # IntAct P75791 3 # InterPro IPR010856 DUF1479 # InterPro IPR027443 IPNS-like # Organism YBIU_ECOLI Escherichia coli (strain K12) # PATRIC 32116845 VBIEscCol129921_0848 # PDB 2DBI X-ray; 2.05 A; A=1-421 # PDB 2DBN X-ray; 1.70 A; A=1-421 # PIR E64819 E64819 # Pfam PF07350 DUF1479 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBIU_ECOLI Uncharacterized protein YbiU # RefSeq NP_415342 NC_000913.3 # RefSeq WP_000168797 NZ_LN832404.1 # eggNOG ENOG41072TH Bacteria # eggNOG ENOG410XRA8 LUCA BLAST swissprot:YBIU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBIU_ECOLI BioCyc ECOL316407:JW0805-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0805-MONOMER BioCyc EcoCyc:G6424-MONOMER http://biocyc.org/getid?id=EcoCyc:G6424-MONOMER DIP DIP-11440N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11440N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3110 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3110 EcoGene EG13326 http://www.ecogene.org/geneInfo.php?eg_id=EG13326 EnsemblBacteria AAC73908 http://www.ensemblgenomes.org/id/AAC73908 EnsemblBacteria AAC73908 http://www.ensemblgenomes.org/id/AAC73908 EnsemblBacteria BAA35502 http://www.ensemblgenomes.org/id/BAA35502 EnsemblBacteria BAA35502 http://www.ensemblgenomes.org/id/BAA35502 EnsemblBacteria BAA35502 http://www.ensemblgenomes.org/id/BAA35502 EnsemblBacteria b0821 http://www.ensemblgenomes.org/id/b0821 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 2.60.120.330 http://www.cathdb.info/version/latest/superfamily/2.60.120.330 GeneID 945439 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945439 HOGENOM HOG000160924 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000160924&db=HOGENOM6 InParanoid P75791 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75791 IntAct P75791 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75791* InterPro IPR010856 http://www.ebi.ac.uk/interpro/entry/IPR010856 InterPro IPR027443 http://www.ebi.ac.uk/interpro/entry/IPR027443 KEGG_Gene ecj:JW0805 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0805 KEGG_Gene eco:b0821 http://www.genome.jp/dbget-bin/www_bget?eco:b0821 MINT MINT-1289806 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1289806 OMA ISEKWHP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ISEKWHP PDB 2DBI http://www.ebi.ac.uk/pdbe-srv/view/entry/2DBI PDB 2DBN http://www.ebi.ac.uk/pdbe-srv/view/entry/2DBN PDBsum 2DBI http://www.ebi.ac.uk/pdbsum/2DBI PDBsum 2DBN http://www.ebi.ac.uk/pdbsum/2DBN PSORT swissprot:YBIU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBIU_ECOLI PSORT-B swissprot:YBIU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBIU_ECOLI PSORT2 swissprot:YBIU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBIU_ECOLI Pfam PF07350 http://pfam.xfam.org/family/PF07350 Phobius swissprot:YBIU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBIU_ECOLI PhylomeDB P75791 http://phylomedb.org/?seqid=P75791 ProteinModelPortal P75791 http://www.proteinmodelportal.org/query/uniprot/P75791 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415342 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415342 RefSeq WP_000168797 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000168797 SMR P75791 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75791 STRING 511145.b0821 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0821&targetmode=cogs UniProtKB YBIU_ECOLI http://www.uniprot.org/uniprot/YBIU_ECOLI UniProtKB-AC P75791 http://www.uniprot.org/uniprot/P75791 charge swissprot:YBIU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBIU_ECOLI eggNOG ENOG41072TH http://eggnogapi.embl.de/nog_data/html/tree/ENOG41072TH eggNOG ENOG410XRA8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRA8 epestfind swissprot:YBIU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBIU_ECOLI garnier swissprot:YBIU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBIU_ECOLI helixturnhelix swissprot:YBIU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBIU_ECOLI hmoment swissprot:YBIU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBIU_ECOLI iep swissprot:YBIU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBIU_ECOLI inforesidue swissprot:YBIU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBIU_ECOLI octanol swissprot:YBIU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBIU_ECOLI pepcoil swissprot:YBIU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBIU_ECOLI pepdigest swissprot:YBIU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBIU_ECOLI pepinfo swissprot:YBIU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBIU_ECOLI pepnet swissprot:YBIU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBIU_ECOLI pepstats swissprot:YBIU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBIU_ECOLI pepwheel swissprot:YBIU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBIU_ECOLI pepwindow swissprot:YBIU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBIU_ECOLI sigcleave swissprot:YBIU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBIU_ECOLI ## Database ID URL or Descriptions # AltName Ascorbate-specific phosphotransferase enzyme IIA component {ECO:0000303|PubMed 12644495} # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=18 uM for L-ascorbate {ECO 0000269|PubMed:12644495}; # BioGrid 4262708 9 # CATALYTIC ACTIVITY [Protein]-N(pi)-phospho-L-histidine + L- ascorbate(Side 1) = [protein]-L-histidine + L-ascorbate 6- phosphate(Side 2). {ECO:0000269|PubMed 12644495}. # DISRUPTION PHENOTYPE Cells lacking this gene are unable to use L- ascorbate. {ECO:0000269|PubMed 12644495}. # DOMAIN ULAC_ECOLI The PTS EIIA type-2 domain is phosphorylated by phospho- HPr on a histidyl residue. Then, it transfers the phosphoryl group to the PTS EIIB type-2 domain. {ECO 0000255|PROSITE- ProRule PRU00417}. # EcoGene EG12495 ulaC # FUNCTION ULAC_ECOLI The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport. {ECO 0000269|PubMed 12644495, ECO 0000305|PubMed 11741871}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0016301 kinase activity; IEA:UniProtKB-KW. # GO_function GO:0090585 protein-phosphocysteine-L-ascorbate-phosphotransferase system transporter activity; IMP:EcoCyc. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IDA:EcoCyc. # GO_process GO:0015882 L-ascorbic acid transport; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # Gene3D 3.40.930.10 -; 1. # INDUCTION ULAC_ECOLI Induced by L-ascorbate. Repressed by UlaR. {ECO 0000269|PubMed 12374842, ECO 0000269|PubMed 12644495, ECO 0000269|PubMed 14996803}. # InterPro IPR002178 PTS_EIIA_type-2_dom # InterPro IPR016152 PTrfase/Anion_transptr # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00283 PTS system, ascorbate-specific II component # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko00053 Ascorbate and aldarate metabolism # KEGG_Pathway ko02060 Phosphotransferase system (PTS) # Organism ULAC_ECOLI Escherichia coli (strain K12) # PATRIC 32123965 VBIEscCol129921_4327 # PIR F65230 F65230 # PROSITE PS00372 PTS_EIIA_TYPE_2_HIS # PROSITE PS51094 PTS_EIIA_TYPE_2 # Pfam PF00359 PTS_EIIA_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Ascorbate-specific PTS system EIIA component {ECO:0000303|PubMed 12644495} # RefSeq NP_418616 NC_000913.3 # RefSeq WP_000776517 NZ_LN832404.1 # SIMILARITY Contains 1 PTS EIIA type-2 domain. {ECO:0000255|PROSITE-ProRule PRU00417}. # SUBCELLULAR LOCATION ULAC_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF55804 SSF55804 # TCDB 4.A.7.1 the pts l-ascorbate (l-asc) family # eggNOG COG1762 LUCA # eggNOG ENOG4106ETB Bacteria BLAST swissprot:ULAC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ULAC_ECOLI BioCyc ECOL316407:JW4153-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4153-MONOMER BioCyc EcoCyc:YJFU-MONOMER http://biocyc.org/getid?id=EcoCyc:YJFU-MONOMER BioCyc MetaCyc:YJFU-MONOMER http://biocyc.org/getid?id=MetaCyc:YJFU-MONOMER COG COG1762 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1762 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.1.302-306.2002 http://dx.doi.org/10.1128/JB.184.1.302-306.2002 DOI 10.1128/JB.184.21.6065-6068.2002 http://dx.doi.org/10.1128/JB.184.21.6065-6068.2002 DOI 10.1128/JB.185.7.2243-2250.2003 http://dx.doi.org/10.1128/JB.185.7.2243-2250.2003 DOI 10.1128/JB.186.6.1720-1728.2004 http://dx.doi.org/10.1128/JB.186.6.1720-1728.2004 EC_number EC:2.7.1.194 {ECO:0000269|PubMed:12644495} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.194 {ECO:0000269|PubMed:12644495} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 2.7.1.194 {ECO:0000269|PubMed:12644495} http://enzyme.expasy.org/EC/2.7.1.194 {ECO:0000269|PubMed:12644495} EchoBASE EB2388 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2388 EcoGene EG12495 http://www.ecogene.org/geneInfo.php?eg_id=EG12495 EnsemblBacteria AAC77152 http://www.ensemblgenomes.org/id/AAC77152 EnsemblBacteria AAC77152 http://www.ensemblgenomes.org/id/AAC77152 EnsemblBacteria BAE78196 http://www.ensemblgenomes.org/id/BAE78196 EnsemblBacteria BAE78196 http://www.ensemblgenomes.org/id/BAE78196 EnsemblBacteria BAE78196 http://www.ensemblgenomes.org/id/BAE78196 EnsemblBacteria b4195 http://www.ensemblgenomes.org/id/b4195 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_function GO:0090585 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090585 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GO_process GO:0015882 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015882 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.40.930.10 http://www.cathdb.info/version/latest/superfamily/3.40.930.10 GeneID 948715 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948715 HOGENOM HOG000227560 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000227560&db=HOGENOM6 InParanoid P69820 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P69820 IntAct P69820 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69820* IntEnz 2.7.1.194 {ECO:0000269|PubMed:12644495} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.194 {ECO:0000269|PubMed:12644495} InterPro IPR002178 http://www.ebi.ac.uk/interpro/entry/IPR002178 InterPro IPR016152 http://www.ebi.ac.uk/interpro/entry/IPR016152 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW4153 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4153 KEGG_Gene eco:b4195 http://www.genome.jp/dbget-bin/www_bget?eco:b4195 KEGG_Orthology KO:K02821 http://www.genome.jp/dbget-bin/www_bget?KO:K02821 KEGG_Pathway ko00053 http://www.genome.jp/kegg-bin/show_pathway?ko00053 KEGG_Pathway ko02060 http://www.genome.jp/kegg-bin/show_pathway?ko02060 KEGG_Reaction rn:R07671 http://www.genome.jp/dbget-bin/www_bget?rn:R07671 OMA VFNHEDN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VFNHEDN PROSITE PS00372 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00372 PROSITE PS51094 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51094 PSORT swissprot:ULAC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ULAC_ECOLI PSORT-B swissprot:ULAC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ULAC_ECOLI PSORT2 swissprot:ULAC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ULAC_ECOLI Pfam PF00359 http://pfam.xfam.org/family/PF00359 Phobius swissprot:ULAC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ULAC_ECOLI PhylomeDB P69820 http://phylomedb.org/?seqid=P69820 ProteinModelPortal P69820 http://www.proteinmodelportal.org/query/uniprot/P69820 PubMed 11741871 http://www.ncbi.nlm.nih.gov/pubmed/11741871 PubMed 12374842 http://www.ncbi.nlm.nih.gov/pubmed/12374842 PubMed 12644495 http://www.ncbi.nlm.nih.gov/pubmed/12644495 PubMed 14996803 http://www.ncbi.nlm.nih.gov/pubmed/14996803 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418616 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418616 RefSeq WP_000776517 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000776517 SMR P69820 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69820 STRING 511145.b4195 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4195&targetmode=cogs STRING COG1762 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1762&targetmode=cogs SUPFAM SSF55804 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55804 TCDB 4.A.7.1 http://www.tcdb.org/search/result.php?tc=4.A.7.1 UniProtKB ULAC_ECOLI http://www.uniprot.org/uniprot/ULAC_ECOLI UniProtKB-AC P69820 http://www.uniprot.org/uniprot/P69820 charge swissprot:ULAC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ULAC_ECOLI eggNOG COG1762 http://eggnogapi.embl.de/nog_data/html/tree/COG1762 eggNOG ENOG4106ETB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106ETB epestfind swissprot:ULAC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ULAC_ECOLI garnier swissprot:ULAC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ULAC_ECOLI helixturnhelix swissprot:ULAC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ULAC_ECOLI hmoment swissprot:ULAC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ULAC_ECOLI iep swissprot:ULAC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ULAC_ECOLI inforesidue swissprot:ULAC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ULAC_ECOLI octanol swissprot:ULAC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ULAC_ECOLI pepcoil swissprot:ULAC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ULAC_ECOLI pepdigest swissprot:ULAC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ULAC_ECOLI pepinfo swissprot:ULAC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ULAC_ECOLI pepnet swissprot:ULAC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ULAC_ECOLI pepstats swissprot:ULAC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ULAC_ECOLI pepwheel swissprot:ULAC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ULAC_ECOLI pepwindow swissprot:ULAC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ULAC_ECOLI sigcleave swissprot:ULAC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ULAC_ECOLI ## Database ID URL or Descriptions # AltName 3-IPM-DH {ECO:0000255|HAMAP-Rule MF_01033} # AltName Beta-IPM dehydrogenase {ECO:0000255|HAMAP-Rule MF_01033} # BIOPHYSICOCHEMICAL PROPERTIES LEU3_ECOLI Kinetic parameters KM=105 uM for 3-isopropylmalate (at 40 degrees Celsius) {ECO 0000269|PubMed 9003442}; KM=321 uM for NAD (at 40 degrees Celsius) {ECO 0000269|PubMed 9003442}; Note=kcat is 69 sec(-1). {ECO 0000269|PubMed 9003442}; pH dependence Optimum pH is 7.6. {ECO 0000269|PubMed 9003442}; Temperature dependence Optimum temperature is 70 degrees Celsius. {ECO 0000269|PubMed 9003442}; # BRENDA 1.1.1.85 2026 # BioGrid 4259727 8 # CATALYTIC ACTIVITY LEU3_ECOLI (2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl- 2-oxopentanoate + CO(2) + NADH. {ECO 0000255|HAMAP-Rule MF_01033, ECO 0000269|PubMed 9003442}. # COFACTOR LEU3_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_01033, ECO 0000269|PubMed 9003442}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000255|HAMAP-Rule MF_01033, ECO 0000269|PubMed 9003442}; Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit. {ECO 0000255|HAMAP- Rule MF_01033}; # ENZYME REGULATION Requires K(+) ions for optimum activity. {ECO:0000269|PubMed 9003442}. # EcoGene EG11577 leuB # FUNCTION LEU3_ECOLI Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. {ECO 0000255|HAMAP-Rule MF_01033, ECO 0000269|PubMed 9003442}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0003862 3-isopropylmalate dehydrogenase activity; IDA:EcoCyc. # GO_function GO:0030145 manganese ion binding; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IDA:EcoCyc. # GO_function GO:0051287 NAD binding; IEA:InterPro. # GO_process GO:0009082 branched-chain amino acid biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0009098 leucine biosynthetic process; IDA:EcoCyc. # GO_process GO:0034198 cellular response to amino acid starvation; IMP:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.718.10 -; 1. # HAMAP MF_01033 LeuB_type1 # IntAct P30125 2 # InterPro IPR001804 Isocitrate/isopropylmalate_DH # InterPro IPR004429 Isopropylmalate_DH # InterPro IPR019818 IsoCit/isopropylmalate_DH_CS # InterPro IPR024084 IsoPropMal-DH-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00290 Valine, leucine and isoleucine biosynthesis # Organism LEU3_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11835 PTHR11835 # PATHWAY LEU3_ECOLI Amino-acid biosynthesis; L-leucine biosynthesis; L- leucine from 3-methyl-2-oxobutanoate step 3/4. {ECO 0000255|HAMAP-Rule MF_01033, ECO 0000305|PubMed 9003442}. # PATRIC 32115249 VBIEscCol129921_0076 # PDB 1CM7 X-ray; 2.06 A; A/B=1-363 # PIR A64729 A64729 # PROSITE PS00470 IDH_IMDH # Pfam PF00180 Iso_dh # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LEU3_ECOLI 3-isopropylmalate dehydrogenase {ECO 0000255|HAMAP-Rule MF_01033, ECO 0000303|PubMed 9003442} # RefSeq NP_414615 NC_000913.3 # RefSeq WP_000042353 NZ_LN832404.1 # SIMILARITY Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. {ECO:0000255|HAMAP- Rule MF_01033, ECO:0000305}. # SMART SM01329 Iso_dh # SUBCELLULAR LOCATION LEU3_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_01033}. # SUBUNIT LEU3_ECOLI Homodimer. {ECO 0000255|HAMAP-Rule MF_01033, ECO 0000269|PubMed 9086278}. # TIGRFAMs TIGR00169 leuB # UniPathway UPA00048 UER00072 # eggNOG COG0473 LUCA # eggNOG ENOG4105C0C Bacteria BLAST swissprot:LEU3_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LEU3_ECOLI BioCyc ECOL316407:JW5807-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5807-MONOMER BioCyc EcoCyc:3-ISOPROPYLMALDEHYDROG-MONOMER http://biocyc.org/getid?id=EcoCyc:3-ISOPROPYLMALDEHYDROG-MONOMER BioCyc MetaCyc:3-ISOPROPYLMALDEHYDROG-MONOMER http://biocyc.org/getid?id=MetaCyc:3-ISOPROPYLMALDEHYDROG-MONOMER COG COG0473 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0473 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1996.0797 http://dx.doi.org/10.1006/jmbi.1996.0797 DOI 10.1016/S0167-4838(96)00157-4 http://dx.doi.org/10.1016/S0167-4838(96)00157-4 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1093/protein/9.8.663 http://dx.doi.org/10.1093/protein/9.8.663 DOI 10.1111/j.1432-1033.1994.tb18623.x http://dx.doi.org/10.1111/j.1432-1033.1994.tb18623.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.85 {ECO:0000255|HAMAP-Rule:MF_01033, ECO:0000269|PubMed:9003442} http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.85 {ECO:0000255|HAMAP-Rule:MF_01033, ECO:0000269|PubMed:9003442} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D17631 http://www.ebi.ac.uk/ena/data/view/D17631 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.1.1.85 {ECO:0000255|HAMAP-Rule:MF_01033, ECO:0000269|PubMed:9003442} http://enzyme.expasy.org/EC/1.1.1.85 {ECO:0000255|HAMAP-Rule:MF_01033, ECO:0000269|PubMed:9003442} EchoBASE EB1537 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1537 EcoGene EG11577 http://www.ecogene.org/geneInfo.php?eg_id=EG11577 EnsemblBacteria AAC73184 http://www.ensemblgenomes.org/id/AAC73184 EnsemblBacteria AAC73184 http://www.ensemblgenomes.org/id/AAC73184 EnsemblBacteria BAB96642 http://www.ensemblgenomes.org/id/BAB96642 EnsemblBacteria BAB96642 http://www.ensemblgenomes.org/id/BAB96642 EnsemblBacteria BAB96642 http://www.ensemblgenomes.org/id/BAB96642 EnsemblBacteria b0073 http://www.ensemblgenomes.org/id/b0073 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0003862 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003862 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051287 GO_process GO:0009082 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009082 GO_process GO:0009098 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009098 GO_process GO:0034198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034198 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.718.10 http://www.cathdb.info/version/latest/superfamily/3.40.718.10 GeneID 944798 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944798 HAMAP MF_01033 http://hamap.expasy.org/unirule/MF_01033 HOGENOM HOG000021112 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000021112&db=HOGENOM6 InParanoid P30125 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30125 IntAct P30125 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P30125* IntEnz 1.1.1.85 {ECO:0000255|HAMAP-Rule:MF_01033, ECO:0000269|PubMed:9003442} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.85 {ECO:0000255|HAMAP-Rule:MF_01033, ECO:0000269|PubMed:9003442} InterPro IPR001804 http://www.ebi.ac.uk/interpro/entry/IPR001804 InterPro IPR004429 http://www.ebi.ac.uk/interpro/entry/IPR004429 InterPro IPR019818 http://www.ebi.ac.uk/interpro/entry/IPR019818 InterPro IPR024084 http://www.ebi.ac.uk/interpro/entry/IPR024084 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5807 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5807 KEGG_Gene eco:b0073 http://www.genome.jp/dbget-bin/www_bget?eco:b0073 KEGG_Orthology KO:K00052 http://www.genome.jp/dbget-bin/www_bget?KO:K00052 KEGG_Pathway ko00290 http://www.genome.jp/kegg-bin/show_pathway?ko00290 KEGG_Reaction rn:R00994 http://www.genome.jp/dbget-bin/www_bget?rn:R00994 KEGG_Reaction rn:R04426 http://www.genome.jp/dbget-bin/www_bget?rn:R04426 KEGG_Reaction rn:R10052 http://www.genome.jp/dbget-bin/www_bget?rn:R10052 OMA RRPKQFD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RRPKQFD PANTHER PTHR11835 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11835 PDB 1CM7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1CM7 PDBsum 1CM7 http://www.ebi.ac.uk/pdbsum/1CM7 PROSITE PS00470 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00470 PSORT swissprot:LEU3_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LEU3_ECOLI PSORT-B swissprot:LEU3_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LEU3_ECOLI PSORT2 swissprot:LEU3_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LEU3_ECOLI Pfam PF00180 http://pfam.xfam.org/family/PF00180 Phobius swissprot:LEU3_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LEU3_ECOLI PhylomeDB P30125 http://phylomedb.org/?seqid=P30125 ProteinModelPortal P30125 http://www.proteinmodelportal.org/query/uniprot/P30125 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8119295 http://www.ncbi.nlm.nih.gov/pubmed/8119295 PubMed 8875643 http://www.ncbi.nlm.nih.gov/pubmed/8875643 PubMed 9003442 http://www.ncbi.nlm.nih.gov/pubmed/9003442 PubMed 9086278 http://www.ncbi.nlm.nih.gov/pubmed/9086278 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_414615 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414615 RefSeq WP_000042353 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000042353 SMART SM01329 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01329 SMR P30125 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P30125 STRING 511145.b0073 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0073&targetmode=cogs STRING COG0473 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0473&targetmode=cogs TIGRFAMs TIGR00169 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00169 UniProtKB LEU3_ECOLI http://www.uniprot.org/uniprot/LEU3_ECOLI UniProtKB-AC P30125 http://www.uniprot.org/uniprot/P30125 charge swissprot:LEU3_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LEU3_ECOLI eggNOG COG0473 http://eggnogapi.embl.de/nog_data/html/tree/COG0473 eggNOG ENOG4105C0C http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C0C epestfind swissprot:LEU3_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LEU3_ECOLI garnier swissprot:LEU3_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LEU3_ECOLI helixturnhelix swissprot:LEU3_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LEU3_ECOLI hmoment swissprot:LEU3_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LEU3_ECOLI iep swissprot:LEU3_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LEU3_ECOLI inforesidue swissprot:LEU3_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LEU3_ECOLI octanol swissprot:LEU3_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LEU3_ECOLI pepcoil swissprot:LEU3_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LEU3_ECOLI pepdigest swissprot:LEU3_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LEU3_ECOLI pepinfo swissprot:LEU3_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LEU3_ECOLI pepnet swissprot:LEU3_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LEU3_ECOLI pepstats swissprot:LEU3_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LEU3_ECOLI pepwheel swissprot:LEU3_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LEU3_ECOLI pepwindow swissprot:LEU3_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LEU3_ECOLI sigcleave swissprot:LEU3_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LEU3_ECOLI ## Database ID URL or Descriptions # BioGrid 4262608 165 # EcoGene EG10434 hemY # FUNCTION HEMY_ECOLI Involved in a late step of protoheme IX synthesis. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006779 porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0042168 heme metabolic process; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 1.25.40.10 -; 3. # IntAct P0ACB7 2 # InterPro IPR005254 Heme_biosyn_assoc_TPR_pro # InterPro IPR010817 HemY_N # InterPro IPR011990 TPR-like_helical_dom # InterPro IPR013026 TPR-contain_dom # InterPro IPR013105 TPR_2 # InterPro IPR019734 TPR_repeat # Organism HEMY_ECOLI Escherichia coli (strain K12) # PATHWAY HEMY_ECOLI Porphyrin-containing compound metabolism; protoheme biosynthesis. # PATRIC 32123103 VBIEscCol129921_3917 # PIR S01694 S01694 # PROSITE PS50005 TPR; 2 # PROSITE PS50293 TPR_REGION # Pfam PF07219 HemY_N # Pfam PF07719 TPR_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HEMY_ECOLI Protein HemY # RefSeq NP_418246 NC_000913.3 # RefSeq WP_000921791 NZ_LN832404.1 # SIMILARITY Contains 2 TPR repeats. {ECO:0000255|PROSITE- ProRule PRU00339}. # SUBCELLULAR LOCATION HEMY_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF48452 SSF48452; 2 # TIGRFAMs TIGR00540 TPR_hemY_coli # eggNOG COG3071 LUCA # eggNOG ENOG410601J Bacteria BLAST swissprot:HEMY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HEMY_ECOLI BioCyc ECOL316407:JW3774-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3774-MONOMER BioCyc EcoCyc:EG10434-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10434-MONOMER COG COG3071 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3071 DIP DIP-47881N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47881N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/16.20.9871 http://dx.doi.org/10.1093/nar/16.20.9871 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X12614 http://www.ebi.ac.uk/ena/data/view/X12614 EchoBASE EB0429 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0429 EcoGene EG10434 http://www.ecogene.org/geneInfo.php?eg_id=EG10434 EnsemblBacteria AAC76805 http://www.ensemblgenomes.org/id/AAC76805 EnsemblBacteria AAC76805 http://www.ensemblgenomes.org/id/AAC76805 EnsemblBacteria BAE77499 http://www.ensemblgenomes.org/id/BAE77499 EnsemblBacteria BAE77499 http://www.ensemblgenomes.org/id/BAE77499 EnsemblBacteria BAE77499 http://www.ensemblgenomes.org/id/BAE77499 EnsemblBacteria b3802 http://www.ensemblgenomes.org/id/b3802 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006779 GO_process GO:0042168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042168 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 1.25.40.10 http://www.cathdb.info/version/latest/superfamily/1.25.40.10 GeneID 948311 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948311 HOGENOM HOG000270888 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000270888&db=HOGENOM6 InParanoid P0ACB7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACB7 IntAct P0ACB7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACB7* InterPro IPR005254 http://www.ebi.ac.uk/interpro/entry/IPR005254 InterPro IPR010817 http://www.ebi.ac.uk/interpro/entry/IPR010817 InterPro IPR011990 http://www.ebi.ac.uk/interpro/entry/IPR011990 InterPro IPR013026 http://www.ebi.ac.uk/interpro/entry/IPR013026 InterPro IPR013105 http://www.ebi.ac.uk/interpro/entry/IPR013105 InterPro IPR019734 http://www.ebi.ac.uk/interpro/entry/IPR019734 KEGG_Gene ecj:JW3774 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3774 KEGG_Gene eco:b3802 http://www.genome.jp/dbget-bin/www_bget?eco:b3802 KEGG_Orthology KO:K02498 http://www.genome.jp/dbget-bin/www_bget?KO:K02498 OMA NPWSRRN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NPWSRRN PROSITE PS50005 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50005 PROSITE PS50293 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50293 PSORT swissprot:HEMY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HEMY_ECOLI PSORT-B swissprot:HEMY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HEMY_ECOLI PSORT2 swissprot:HEMY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HEMY_ECOLI Pfam PF07219 http://pfam.xfam.org/family/PF07219 Pfam PF07719 http://pfam.xfam.org/family/PF07719 Phobius swissprot:HEMY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HEMY_ECOLI ProteinModelPortal P0ACB7 http://www.proteinmodelportal.org/query/uniprot/P0ACB7 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3054815 http://www.ncbi.nlm.nih.gov/pubmed/3054815 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418246 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418246 RefSeq WP_000921791 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000921791 SMR P0ACB7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACB7 STRING 511145.b3802 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3802&targetmode=cogs STRING COG3071 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3071&targetmode=cogs SUPFAM SSF48452 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48452 TIGRFAMs TIGR00540 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00540 UniProtKB HEMY_ECOLI http://www.uniprot.org/uniprot/HEMY_ECOLI UniProtKB-AC P0ACB7 http://www.uniprot.org/uniprot/P0ACB7 charge swissprot:HEMY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HEMY_ECOLI eggNOG COG3071 http://eggnogapi.embl.de/nog_data/html/tree/COG3071 eggNOG ENOG410601J http://eggnogapi.embl.de/nog_data/html/tree/ENOG410601J epestfind swissprot:HEMY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HEMY_ECOLI garnier swissprot:HEMY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HEMY_ECOLI helixturnhelix swissprot:HEMY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HEMY_ECOLI hmoment swissprot:HEMY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HEMY_ECOLI iep swissprot:HEMY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HEMY_ECOLI inforesidue swissprot:HEMY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HEMY_ECOLI octanol swissprot:HEMY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HEMY_ECOLI pepcoil swissprot:HEMY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HEMY_ECOLI pepdigest swissprot:HEMY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HEMY_ECOLI pepinfo swissprot:HEMY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HEMY_ECOLI pepnet swissprot:HEMY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HEMY_ECOLI pepstats swissprot:HEMY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HEMY_ECOLI pepwheel swissprot:HEMY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HEMY_ECOLI pepwindow swissprot:HEMY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HEMY_ECOLI sigcleave swissprot:HEMY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HEMY_ECOLI ## Database ID URL or Descriptions # BioGrid 4260701 7 # CATALYTIC ACTIVITY TORA_ECOLI Trimethylamine + 2 (ferricytochrome c)-subunit + H(2)O = trimethylamine N-oxide + 2 (ferrocytochrome c)-subunit + 2 H(+). # COFACTOR TORA_ECOLI Name=Mo-bis(molybdopterin guanine dinucleotide); Xref=ChEBI CHEBI 60539; Evidence={ECO 0000250}; Note=Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit. {ECO 0000250}; # EcoGene EG11814 torA # FUNCTION TORA_ECOLI Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0009055 electron carrier activity; IEA:InterPro. # GO_function GO:0030151 molybdenum ion binding; IDA:EcoCyc. # GO_function GO:0048037 cofactor binding; IDA:EcoCyc. # GO_function GO:0050626 trimethylamine-N-oxide reductase (cytochrome c) activity; IMP:EcoliWiki. # GO_process GO:0009060 aerobic respiration; IEP:EcoCyc. # GO_process GO:0009061 anaerobic respiration; IEP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # INTERACTION TORA_ECOLI P0A9M0 lon; NbExp=2; IntAct=EBI-557008, EBI-547203; P33226 torC; NbExp=3; IntAct=EBI-557008, EBI-553710; P36662 torD; NbExp=24; IntAct=EBI-557008, EBI-6406226; # IntAct P33225 17 # InterPro IPR006311 TAT_signal # InterPro IPR006655 Mopterin_OxRdtase_prok_CS # InterPro IPR006656 Mopterin_OxRdtase # InterPro IPR006657 MoPterin_dinucl-bd_dom # InterPro IPR006658 BisC # InterPro IPR009010 Asp_de-COase-like_dom # InterPro IPR011887 TorA # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02020 Two-component system # Organism TORA_ECOLI Escherichia coli (strain K12) # PATRIC 32117219 VBIEscCol129921_1033 # PIR C64841 C64841 # PROSITE PS00490 MOLYBDOPTERIN_PROK_2 # PROSITE PS00932 MOLYBDOPTERIN_PROK_3 # PROSITE PS51318 TAT # PTM TORA_ECOLI Exported by the Tat system. The position of the signal peptide cleavage has been experimentally proven. # Pfam PF00384 Molybdopterin # Pfam PF01568 Molydop_binding # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TORA_ECOLI Trimethylamine-N-oxide reductase 1 # RefSeq NP_415517 NC_000913.3 # RefSeq WP_001062091 NZ_LN832404.1 # SIMILARITY Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. {ECO 0000305}. # SUBCELLULAR LOCATION TORA_ECOLI Periplasm {ECO 0000269|PubMed 2512991}. # SUBUNIT TORA_ECOLI Interacts with the N-terminal domain of TorC. # SUPFAM SSF50692 SSF50692 # TCDB 5.A.3.4 the prokaryotic molybdopterin-containing oxidoreductase (pmo) family # TIGRFAMs TIGR00509 bisC_fam # TIGRFAMs TIGR02164 torA # eggNOG COG0243 LUCA # eggNOG ENOG4107QY8 Bacteria BLAST swissprot:TORA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TORA_ECOLI BioCyc ECOL316407:JW0982-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0982-MONOMER BioCyc EcoCyc:TORA-MONOMER http://biocyc.org/getid?id=EcoCyc:TORA-MONOMER BioCyc MetaCyc:TORA-MONOMER http://biocyc.org/getid?id=MetaCyc:TORA-MONOMER COG COG0243 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0243 DIP DIP-11013N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11013N DOI 10.1016/0167-4838(89)90220-3 http://dx.doi.org/10.1016/0167-4838(89)90220-3 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.91.3.1054 http://dx.doi.org/10.1073/pnas.91.3.1054 DOI 10.1074/jbc.M610507200 http://dx.doi.org/10.1074/jbc.M610507200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/emboj/17.1.101 http://dx.doi.org/10.1093/emboj/17.1.101 DOI 10.1111/j.1365-2958.1994.tb00393.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb00393.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.7.2.3 http://www.genome.jp/dbget-bin/www_bget?EC:1.7.2.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D16500 http://www.ebi.ac.uk/ena/data/view/D16500 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X73888 http://www.ebi.ac.uk/ena/data/view/X73888 ENZYME 1.7.2.3 http://enzyme.expasy.org/EC/1.7.2.3 EchoBASE EB1761 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1761 EcoGene EG11814 http://www.ecogene.org/geneInfo.php?eg_id=EG11814 EnsemblBacteria AAC74082 http://www.ensemblgenomes.org/id/AAC74082 EnsemblBacteria AAC74082 http://www.ensemblgenomes.org/id/AAC74082 EnsemblBacteria BAA36139 http://www.ensemblgenomes.org/id/BAA36139 EnsemblBacteria BAA36139 http://www.ensemblgenomes.org/id/BAA36139 EnsemblBacteria BAA36139 http://www.ensemblgenomes.org/id/BAA36139 EnsemblBacteria b0997 http://www.ensemblgenomes.org/id/b0997 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0030151 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030151 GO_function GO:0048037 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048037 GO_function GO:0050626 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050626 GO_process GO:0009060 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009060 GO_process GO:0009061 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009061 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GeneID 946267 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946267 HOGENOM HOG000284391 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000284391&db=HOGENOM6 InParanoid P33225 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33225 IntAct P33225 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33225* IntEnz 1.7.2.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.7.2.3 InterPro IPR006311 http://www.ebi.ac.uk/interpro/entry/IPR006311 InterPro IPR006655 http://www.ebi.ac.uk/interpro/entry/IPR006655 InterPro IPR006656 http://www.ebi.ac.uk/interpro/entry/IPR006656 InterPro IPR006657 http://www.ebi.ac.uk/interpro/entry/IPR006657 InterPro IPR006658 http://www.ebi.ac.uk/interpro/entry/IPR006658 InterPro IPR009010 http://www.ebi.ac.uk/interpro/entry/IPR009010 InterPro IPR011887 http://www.ebi.ac.uk/interpro/entry/IPR011887 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0982 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0982 KEGG_Gene eco:b0997 http://www.genome.jp/dbget-bin/www_bget?eco:b0997 KEGG_Orthology KO:K07811 http://www.genome.jp/dbget-bin/www_bget?KO:K07811 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 MINT MINT-6796194 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-6796194 OMA TIVVHDP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TIVVHDP PROSITE PS00490 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00490 PROSITE PS00932 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00932 PROSITE PS51318 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51318 PSORT swissprot:TORA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TORA_ECOLI PSORT-B swissprot:TORA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TORA_ECOLI PSORT2 swissprot:TORA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TORA_ECOLI Pfam PF00384 http://pfam.xfam.org/family/PF00384 Pfam PF01568 http://pfam.xfam.org/family/PF01568 Phobius swissprot:TORA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TORA_ECOLI PhylomeDB P33225 http://phylomedb.org/?seqid=P33225 ProteinModelPortal P33225 http://www.proteinmodelportal.org/query/uniprot/P33225 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17218314 http://www.ncbi.nlm.nih.gov/pubmed/17218314 PubMed 2512991 http://www.ncbi.nlm.nih.gov/pubmed/2512991 PubMed 8022286 http://www.ncbi.nlm.nih.gov/pubmed/8022286 PubMed 8302830 http://www.ncbi.nlm.nih.gov/pubmed/8302830 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9427745 http://www.ncbi.nlm.nih.gov/pubmed/9427745 RefSeq NP_415517 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415517 RefSeq WP_001062091 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001062091 SMR P33225 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33225 STRING 511145.b0997 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0997&targetmode=cogs STRING COG0243 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0243&targetmode=cogs SUPFAM SSF50692 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50692 TCDB 5.A.3.4 http://www.tcdb.org/search/result.php?tc=5.A.3.4 TIGRFAMs TIGR00509 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00509 TIGRFAMs TIGR02164 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02164 UniProtKB TORA_ECOLI http://www.uniprot.org/uniprot/TORA_ECOLI UniProtKB-AC P33225 http://www.uniprot.org/uniprot/P33225 charge swissprot:TORA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TORA_ECOLI eggNOG COG0243 http://eggnogapi.embl.de/nog_data/html/tree/COG0243 eggNOG ENOG4107QY8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QY8 epestfind swissprot:TORA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TORA_ECOLI garnier swissprot:TORA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TORA_ECOLI helixturnhelix swissprot:TORA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TORA_ECOLI hmoment swissprot:TORA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TORA_ECOLI iep swissprot:TORA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TORA_ECOLI inforesidue swissprot:TORA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TORA_ECOLI octanol swissprot:TORA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TORA_ECOLI pepcoil swissprot:TORA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TORA_ECOLI pepdigest swissprot:TORA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TORA_ECOLI pepinfo swissprot:TORA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TORA_ECOLI pepnet swissprot:TORA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TORA_ECOLI pepstats swissprot:TORA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TORA_ECOLI pepwheel swissprot:TORA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TORA_ECOLI pepwindow swissprot:TORA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TORA_ECOLI sigcleave swissprot:TORA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TORA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262341 9 # EcoGene EG13074 cptA # FUNCTION CPTA_ECOLI Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB; inhibits FtsZ GTP-dependent polymerization as well as MreB ATP-dependent polymerization. {ECO 0000269|PubMed 22239607}. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_process GO:0008360 regulation of cell shape; IEA:UniProtKB-KW. # GO_process GO:0032091 negative regulation of protein binding; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0008150 biological_process # InterPro IPR009883 Cpta_toxin # Organism CPTA_ECOLI Escherichia coli (strain K12) # PATRIC 32121204 VBIEscCol129921_2990 # PIR H65073 H65073 # PIRSF PIRSF020653 UCP020653 # Pfam PF07254 Cpta_toxin # ProDom PD083358 DUF1434 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CPTA_ECOLI Toxin CptA # RefSeq NP_417372 NC_000913.3 # RefSeq WP_000244777 NZ_LN832404.1 # SUBCELLULAR LOCATION CPTA_ECOLI Cell inner membrane {ECO 0000269|PubMed 22239607}; Multi-pass membrane protein {ECO 0000269|PubMed 22239607}. # SUBUNIT Interacts with MreB and FtsZ; interaction with the latter requires FtsZ residues 33-49. {ECO:0000269|PubMed 22239607}. # eggNOG ENOG4108YDB Bacteria # eggNOG ENOG4111R98 LUCA BLAST swissprot:CPTA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CPTA_ECOLI BioCyc ECOL316407:JW2864-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2864-MONOMER BioCyc EcoCyc:G7509-MONOMER http://biocyc.org/getid?id=EcoCyc:G7509-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1574-6968.2012.02496.x http://dx.doi.org/10.1111/j.1574-6968.2012.02496.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 EchoBASE EB2884 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2884 EcoGene EG13074 http://www.ecogene.org/geneInfo.php?eg_id=EG13074 EnsemblBacteria AAC75934 http://www.ensemblgenomes.org/id/AAC75934 EnsemblBacteria AAC75934 http://www.ensemblgenomes.org/id/AAC75934 EnsemblBacteria BAE76961 http://www.ensemblgenomes.org/id/BAE76961 EnsemblBacteria BAE76961 http://www.ensemblgenomes.org/id/BAE76961 EnsemblBacteria BAE76961 http://www.ensemblgenomes.org/id/BAE76961 EnsemblBacteria b2896 http://www.ensemblgenomes.org/id/b2896 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0032091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032091 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 947379 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947379 HOGENOM HOG000124380 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000124380&db=HOGENOM6 IntAct Q46824 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46824* InterPro IPR009883 http://www.ebi.ac.uk/interpro/entry/IPR009883 KEGG_Gene ecj:JW2864 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2864 KEGG_Gene eco:b2896 http://www.genome.jp/dbget-bin/www_bget?eco:b2896 OMA WLASDSM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WLASDSM PSORT swissprot:CPTA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CPTA_ECOLI PSORT-B swissprot:CPTA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CPTA_ECOLI PSORT2 swissprot:CPTA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CPTA_ECOLI Pfam PF07254 http://pfam.xfam.org/family/PF07254 Phobius swissprot:CPTA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CPTA_ECOLI ProteinModelPortal Q46824 http://www.proteinmodelportal.org/query/uniprot/Q46824 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22239607 http://www.ncbi.nlm.nih.gov/pubmed/22239607 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417372 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417372 RefSeq WP_000244777 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000244777 STRING 511145.b2896 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2896&targetmode=cogs UniProtKB CPTA_ECOLI http://www.uniprot.org/uniprot/CPTA_ECOLI UniProtKB-AC Q46824 http://www.uniprot.org/uniprot/Q46824 charge swissprot:CPTA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CPTA_ECOLI eggNOG ENOG4108YDB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108YDB eggNOG ENOG4111R98 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111R98 epestfind swissprot:CPTA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CPTA_ECOLI garnier swissprot:CPTA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CPTA_ECOLI helixturnhelix swissprot:CPTA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CPTA_ECOLI hmoment swissprot:CPTA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CPTA_ECOLI iep swissprot:CPTA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CPTA_ECOLI inforesidue swissprot:CPTA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CPTA_ECOLI octanol swissprot:CPTA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CPTA_ECOLI pepcoil swissprot:CPTA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CPTA_ECOLI pepdigest swissprot:CPTA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CPTA_ECOLI pepinfo swissprot:CPTA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CPTA_ECOLI pepnet swissprot:CPTA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CPTA_ECOLI pepstats swissprot:CPTA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CPTA_ECOLI pepwheel swissprot:CPTA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CPTA_ECOLI pepwindow swissprot:CPTA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CPTA_ECOLI sigcleave swissprot:CPTA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CPTA_ECOLI ## Database ID URL or Descriptions # AltName 5FCL_ECOLI 5,10-methenyltetrahydrofolate synthetase # BioGrid 4261171 226 # CATALYTIC ACTIVITY 5FCL_ECOLI ATP + 5-formyltetrahydrofolate = ADP + phosphate + 5,10-methenyltetrahydrofolate. # DISRUPTION PHENOTYPE Cells lacking this gene does not cause a growth defect in rich or minimal medium. However, when grown in minimal medium with added glycine, the mutant accumulates 5-CHO- THF. If the only nitrogen source in minimal medium is glycine, the mutant shows a severe growth defect, likely due to inhibition of serine hydroxymethyltransferase (SHMT) and the glycine cleavage system by the accumulated 5-CHO-THF. This phenotype can be complemented by the glutamate formiminotransferase (FT). {ECO:0000269|PubMed 20952389}. # EcoGene EG11158 ygfA # FUNCTION 5FCL_ECOLI Involved in the removal of 5-formyltetrahydrofolate. In vitro, it is a potent inhibitor of various folate-dependent enzymes in the C1 metabolism network and in vivo it might function as a folate storage. 5-formyltetrahydrofolate is also used as an antifolate rescue agent in cancer chemotherapy. Catalyzes the irreversible ATP-dependent transformation of 5- formyltetrahydrofolate (5-CHO-THF) to form 5,10- methenyltetrahydrofolate (5,10-CH=THF). The reverse reaction is catalyzed by the serine hydroxymethyltransferase GlyA (SHMT). {ECO 0000269|PubMed 18519731, ECO 0000269|PubMed 20952389}. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0030272 5-formyltetrahydrofolate cyclo-ligase activity; IMP:EcoCyc. # GO_process GO:0009396 folic acid-containing compound biosynthetic process; IBA:GO_Central. # GO_process GO:0022611 dormancy process; IMP:EcoCyc. # GO_process GO:0035999 tetrahydrofolate interconversion; IBA:GO_Central. # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.10420 -; 1. # INDUCTION During biofilm formation. {ECO:0000269|PubMed 21036909}. # INTERACTION 5FCL_ECOLI P0A763 ndk; NbExp=3; IntAct=EBI-555094, EBI-370139; # IntAct P0AC28 9 # InterPro IPR002698 FTHF_cligase # InterPro IPR024185 FTHF_cligase-like # Organism 5FCL_ECOLI Escherichia coli (strain K12) # PANTHER PTHR23407:SF1 PTHR23407:SF1 # PATRIC 32121236 VBIEscCol129921_3006 # PIR A21894 QQEC2K # PIRSF PIRSF006806 FTHF_cligase # Pfam PF01812 5-FTHF_cyc-lig # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 5FCL_ECOLI 5-formyltetrahydrofolate cyclo-ligase # RefSeq NP_417387 NC_000913.3 # SIMILARITY Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. {ECO 0000305}. # TIGRFAMs TIGR02727 MTHFS_bact # eggNOG COG0212 LUCA # eggNOG ENOG4105MK2 Bacteria BLAST swissprot:5FCL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:5FCL_ECOLI BioCyc ECOL316407:JW2879-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2879-MONOMER BioCyc EcoCyc:EG11158-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11158-MONOMER BioCyc MetaCyc:EG11158-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11158-MONOMER DIP DIP-48194N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48194N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M110.150201 http://dx.doi.org/10.1074/jbc.M110.150201 DOI 10.1074/jbc.M110.190504 http://dx.doi.org/10.1074/jbc.M110.190504 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AAC.00144-08 http://dx.doi.org/10.1128/AAC.00144-08 EC_number EC:6.3.3.2 http://www.genome.jp/dbget-bin/www_bget?EC:6.3.3.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M12965 http://www.ebi.ac.uk/ena/data/view/M12965 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 ENZYME 6.3.3.2 http://enzyme.expasy.org/EC/6.3.3.2 EchoBASE EB1147 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1147 EcoGene EG11158 http://www.ecogene.org/geneInfo.php?eg_id=EG11158 EnsemblBacteria AAC75949 http://www.ensemblgenomes.org/id/AAC75949 EnsemblBacteria AAC75949 http://www.ensemblgenomes.org/id/AAC75949 EnsemblBacteria BAE76976 http://www.ensemblgenomes.org/id/BAE76976 EnsemblBacteria BAE76976 http://www.ensemblgenomes.org/id/BAE76976 EnsemblBacteria BAE76976 http://www.ensemblgenomes.org/id/BAE76976 EnsemblBacteria b2912 http://www.ensemblgenomes.org/id/b2912 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0030272 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030272 GO_process GO:0009396 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009396 GO_process GO:0022611 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022611 GO_process GO:0035999 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035999 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.10420 http://www.cathdb.info/version/latest/superfamily/3.40.50.10420 GeneID 945167 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945167 HOGENOM HOG000007300 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000007300&db=HOGENOM6 InParanoid P0AC28 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AC28 IntAct P0AC28 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AC28* IntEnz 6.3.3.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.3.2 InterPro IPR002698 http://www.ebi.ac.uk/interpro/entry/IPR002698 InterPro IPR024185 http://www.ebi.ac.uk/interpro/entry/IPR024185 KEGG_Gene ecj:JW2879 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2879 KEGG_Gene eco:b2912 http://www.genome.jp/dbget-bin/www_bget?eco:b2912 MINT MINT-1249443 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1249443 OMA FREWRAG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FREWRAG PANTHER PTHR23407:SF1 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23407:SF1 PSORT swissprot:5FCL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:5FCL_ECOLI PSORT-B swissprot:5FCL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:5FCL_ECOLI PSORT2 swissprot:5FCL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:5FCL_ECOLI Pfam PF01812 http://pfam.xfam.org/family/PF01812 Phobius swissprot:5FCL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:5FCL_ECOLI PhylomeDB P0AC28 http://phylomedb.org/?seqid=P0AC28 ProteinModelPortal P0AC28 http://www.proteinmodelportal.org/query/uniprot/P0AC28 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18519731 http://www.ncbi.nlm.nih.gov/pubmed/18519731 PubMed 20952389 http://www.ncbi.nlm.nih.gov/pubmed/20952389 PubMed 21036909 http://www.ncbi.nlm.nih.gov/pubmed/21036909 PubMed 2579060 http://www.ncbi.nlm.nih.gov/pubmed/2579060 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417387 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417387 SMR P0AC28 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AC28 STRING 511145.b2912 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2912&targetmode=cogs TIGRFAMs TIGR02727 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02727 UniProtKB 5FCL_ECOLI http://www.uniprot.org/uniprot/5FCL_ECOLI UniProtKB-AC P0AC28 http://www.uniprot.org/uniprot/P0AC28 charge swissprot:5FCL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:5FCL_ECOLI eggNOG COG0212 http://eggnogapi.embl.de/nog_data/html/tree/COG0212 eggNOG ENOG4105MK2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105MK2 epestfind swissprot:5FCL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:5FCL_ECOLI garnier swissprot:5FCL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:5FCL_ECOLI helixturnhelix swissprot:5FCL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:5FCL_ECOLI hmoment swissprot:5FCL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:5FCL_ECOLI iep swissprot:5FCL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:5FCL_ECOLI inforesidue swissprot:5FCL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:5FCL_ECOLI octanol swissprot:5FCL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:5FCL_ECOLI pepcoil swissprot:5FCL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:5FCL_ECOLI pepdigest swissprot:5FCL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:5FCL_ECOLI pepinfo swissprot:5FCL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:5FCL_ECOLI pepnet swissprot:5FCL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:5FCL_ECOLI pepstats swissprot:5FCL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:5FCL_ECOLI pepwheel swissprot:5FCL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:5FCL_ECOLI pepwindow swissprot:5FCL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:5FCL_ECOLI sigcleave swissprot:5FCL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:5FCL_ECOLI ## Database ID URL or Descriptions # BRENDA 1.1.1.23 2026 # BioGrid 4260403 18 # CATALYTIC ACTIVITY L-histidinol + H(2)O + 2 NAD(+) = L-histidine + 2 NADH. {ECO:0000255|HAMAP-Rule MF_01024}. # CDD cd06572 Histidinol_dh # COFACTOR HISX_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 11842181}; Note=Binds 1 zinc ion per subunit. {ECO 0000269|PubMed 11842181}; # EcoGene EG10447 hisD # FUNCTION HISX_ECOLI Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. {ECO 0000255|HAMAP-Rule MF_01024}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004399 histidinol dehydrogenase activity; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0030145 manganese ion binding; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IDA:EcoCyc. # GO_function GO:0051287 NAD binding; IEA:InterPro. # GO_process GO:0000105 histidine biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # HAMAP MF_01024 HisD # IntAct P06988 7 # InterPro IPR001692 Histidinol_DH_CS # InterPro IPR012131 Hstdl_DH # InterPro IPR016161 Ald_DH/histidinol_DH # InterPro IPR022695 Histidinol_DH_monofunct # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00340 Histidine metabolism # Organism HISX_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-histidine biosynthesis; L- histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. {ECO 0000255|HAMAP-Rule:MF_01024}. # PATRIC 32119375 VBIEscCol129921_2097 # PDB 1K75 X-ray; 1.75 A; A/B=1-434 # PDB 1KAE X-ray; 1.70 A; A/B=1-434 # PDB 1KAH X-ray; 2.10 A; A/B=1-434 # PDB 1KAR X-ray; 2.10 A; A/B=1-434 # PIR C64967 DEECHT # PIRSF PIRSF000099 Histidinol_dh # PRINTS PR00083 HOLDHDRGNASE # PROSITE PS00611 HISOL_DEHYDROGENASE # Pfam PF00815 Histidinol_dh # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Histidinol dehydrogenase {ECO:0000255|HAMAP-Rule MF_01024} # RefSeq NP_416524 NC_000913.3 # RefSeq WP_000009594 NZ_LN832404.1 # SIMILARITY Belongs to the histidinol dehydrogenase family. {ECO:0000255|HAMAP-Rule MF_01024, ECO:0000305}. # SUBUNIT Homodimer. {ECO:0000255|HAMAP-Rule MF_01024}. # SUPFAM SSF53720 SSF53720 # TIGRFAMs TIGR00069 hisD # UniPathway UPA00031 UER00014 # eggNOG COG0141 LUCA # eggNOG ENOG4105CEK Bacteria BLAST swissprot:HISX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HISX_ECOLI BioCyc ECOL316407:JW2002-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2002-MONOMER BioCyc EcoCyc:HISTDEHYD-MONOMER http://biocyc.org/getid?id=EcoCyc:HISTDEHYD-MONOMER BioCyc MetaCyc:HISTDEHYD-MONOMER http://biocyc.org/getid?id=MetaCyc:HISTDEHYD-MONOMER COG COG0141 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0141 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1007/BF00422061 http://dx.doi.org/10.1007/BF00422061 DOI 10.1016/0022-2836(88)90194-5 http://dx.doi.org/10.1016/0022-2836(88)90194-5 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.022476199 http://dx.doi.org/10.1073/pnas.022476199 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/nar/18.12.3634 http://dx.doi.org/10.1093/nar/18.12.3634 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.23 {ECO:0000255|HAMAP-Rule:MF_01024} http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.23 {ECO:0000255|HAMAP-Rule:MF_01024} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M10483 http://www.ebi.ac.uk/ena/data/view/M10483 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X03972 http://www.ebi.ac.uk/ena/data/view/X03972 EMBL X13462 http://www.ebi.ac.uk/ena/data/view/X13462 EMBL X52656 http://www.ebi.ac.uk/ena/data/view/X52656 ENZYME 1.1.1.23 {ECO:0000255|HAMAP-Rule:MF_01024} http://enzyme.expasy.org/EC/1.1.1.23 {ECO:0000255|HAMAP-Rule:MF_01024} EchoBASE EB0442 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0442 EcoGene EG10447 http://www.ecogene.org/geneInfo.php?eg_id=EG10447 EnsemblBacteria AAC75081 http://www.ensemblgenomes.org/id/AAC75081 EnsemblBacteria AAC75081 http://www.ensemblgenomes.org/id/AAC75081 EnsemblBacteria BAA15851 http://www.ensemblgenomes.org/id/BAA15851 EnsemblBacteria BAA15851 http://www.ensemblgenomes.org/id/BAA15851 EnsemblBacteria BAA15851 http://www.ensemblgenomes.org/id/BAA15851 EnsemblBacteria b2020 http://www.ensemblgenomes.org/id/b2020 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004399 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051287 GO_process GO:0000105 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000105 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 946531 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946531 HAMAP MF_01024 http://hamap.expasy.org/unirule/MF_01024 HOGENOM HOG000243914 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000243914&db=HOGENOM6 InParanoid P06988 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P06988 IntAct P06988 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P06988* IntEnz 1.1.1.23 {ECO:0000255|HAMAP-Rule:MF_01024} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.23 {ECO:0000255|HAMAP-Rule:MF_01024} InterPro IPR001692 http://www.ebi.ac.uk/interpro/entry/IPR001692 InterPro IPR012131 http://www.ebi.ac.uk/interpro/entry/IPR012131 InterPro IPR016161 http://www.ebi.ac.uk/interpro/entry/IPR016161 InterPro IPR022695 http://www.ebi.ac.uk/interpro/entry/IPR022695 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2002 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2002 KEGG_Gene eco:b2020 http://www.genome.jp/dbget-bin/www_bget?eco:b2020 KEGG_Orthology KO:K00013 http://www.genome.jp/dbget-bin/www_bget?KO:K00013 KEGG_Pathway ko00340 http://www.genome.jp/kegg-bin/show_pathway?ko00340 KEGG_Reaction rn:R01163 http://www.genome.jp/dbget-bin/www_bget?rn:R01163 KEGG_Reaction rn:R03012 http://www.genome.jp/dbget-bin/www_bget?rn:R03012 OMA GGTARFY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GGTARFY PDB 1K75 http://www.ebi.ac.uk/pdbe-srv/view/entry/1K75 PDB 1KAE http://www.ebi.ac.uk/pdbe-srv/view/entry/1KAE PDB 1KAH http://www.ebi.ac.uk/pdbe-srv/view/entry/1KAH PDB 1KAR http://www.ebi.ac.uk/pdbe-srv/view/entry/1KAR PDBsum 1K75 http://www.ebi.ac.uk/pdbsum/1K75 PDBsum 1KAE http://www.ebi.ac.uk/pdbsum/1KAE PDBsum 1KAH http://www.ebi.ac.uk/pdbsum/1KAH PDBsum 1KAR http://www.ebi.ac.uk/pdbsum/1KAR PRINTS PR00083 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00083 PROSITE PS00611 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00611 PSORT swissprot:HISX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HISX_ECOLI PSORT-B swissprot:HISX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HISX_ECOLI PSORT2 swissprot:HISX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HISX_ECOLI Pfam PF00815 http://pfam.xfam.org/family/PF00815 Phobius swissprot:HISX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HISX_ECOLI PhylomeDB P06988 http://phylomedb.org/?seqid=P06988 ProteinModelPortal P06988 http://www.proteinmodelportal.org/query/uniprot/P06988 PubMed 11842181 http://www.ncbi.nlm.nih.gov/pubmed/11842181 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2194167 http://www.ncbi.nlm.nih.gov/pubmed/2194167 PubMed 3018428 http://www.ncbi.nlm.nih.gov/pubmed/3018428 PubMed 3062174 http://www.ncbi.nlm.nih.gov/pubmed/3062174 PubMed 6246067 http://www.ncbi.nlm.nih.gov/pubmed/6246067 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_416524 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416524 RefSeq WP_000009594 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000009594 SMR P06988 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P06988 STRING 511145.b2020 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2020&targetmode=cogs STRING COG0141 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0141&targetmode=cogs SUPFAM SSF53720 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53720 SWISS-2DPAGE P06988 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P06988 TIGRFAMs TIGR00069 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00069 UniProtKB HISX_ECOLI http://www.uniprot.org/uniprot/HISX_ECOLI UniProtKB-AC P06988 http://www.uniprot.org/uniprot/P06988 charge swissprot:HISX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HISX_ECOLI eggNOG COG0141 http://eggnogapi.embl.de/nog_data/html/tree/COG0141 eggNOG ENOG4105CEK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CEK epestfind swissprot:HISX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HISX_ECOLI garnier swissprot:HISX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HISX_ECOLI helixturnhelix swissprot:HISX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HISX_ECOLI hmoment swissprot:HISX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HISX_ECOLI iep swissprot:HISX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HISX_ECOLI inforesidue swissprot:HISX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HISX_ECOLI octanol swissprot:HISX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HISX_ECOLI pepcoil swissprot:HISX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HISX_ECOLI pepdigest swissprot:HISX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HISX_ECOLI pepinfo swissprot:HISX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HISX_ECOLI pepnet swissprot:HISX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HISX_ECOLI pepstats swissprot:HISX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HISX_ECOLI pepwheel swissprot:HISX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HISX_ECOLI pepwindow swissprot:HISX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HISX_ECOLI sigcleave swissprot:HISX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HISX_ECOLI ## Database ID URL or Descriptions # AltName ARGE_ECOLI N-acetylornithinase # BRENDA 3.5.1.16 2026 # BioGrid 4259568 12 # CATALYTIC ACTIVITY ARGE_ECOLI N(2)-acetyl-L-ornithine + H(2)O = acetate + L- ornithine. # CDD cd03894 M20_ArgE # COFACTOR ARGE_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Name=Co(2+); Xref=ChEBI CHEBI 48828; Note=Binds 2 Zn(2+) or Co(2+) ions per subunit.; # COFACTOR Name=glutathione; Xref=ChEBI:CHEBI 57925; # EcoGene EG11286 argE # FUNCTION ARGE_ECOLI Displays a broad specificity and can also deacylate substrates such as acetylarginine, acetylhistidine or acetylglutamate semialdehyde. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0008237 metallopeptidase activity; IEA:InterPro. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_function GO:0008777 acetylornithine deacetylase activity; IDA:EcoliWiki. # GO_function GO:0050897 cobalt ion binding; IDA:EcoCyc. # GO_process GO:0006526 arginine biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.30.70.360 -; 1. # HAMAP MF_01108 ArgE # InterPro IPR001261 ArgE/DapE_CS # InterPro IPR002933 Peptidase_M20 # InterPro IPR010169 AcOrn-deacetyl # InterPro IPR011650 Peptidase_M20_dimer # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00330 Arginine and proline metabolism # Organism ARGE_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-arginine biosynthesis; L- ornithine from N(2)-acetyl-L-ornithine (linear) step 1/1. # PATRIC 32123435 VBIEscCol129921_4078 # PIR B42377 B42377 # PROSITE PS00758 ARGE_DAPE_CPG2_1 # PROSITE PS00759 ARGE_DAPE_CPG2_2 # Pfam PF01546 Peptidase_M20 # Pfam PF07687 M20_dimer # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ARGE_ECOLI Acetylornithine deacetylase # RefSeq NP_418392 NC_000913.3 # RefSeq WP_001298964 NZ_CP014272.1 # SIMILARITY Belongs to the peptidase M20A family. ArgE subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION ARGE_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT ARGE_ECOLI Homodimer. # SUPFAM SSF55031 SSF55031 # TIGRFAMs TIGR01892 AcOrn-deacetyl # UniPathway UPA00068 UER00110 # eggNOG COG0624 LUCA # eggNOG ENOG4105CWC Bacteria BLAST swissprot:ARGE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARGE_ECOLI BioCyc ECOL316407:JW3929-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3929-MONOMER BioCyc EcoCyc:ACETYLORNDEACET-MONOMER http://biocyc.org/getid?id=EcoCyc:ACETYLORNDEACET-MONOMER BioCyc MetaCyc:ACETYLORNDEACET-MONOMER http://biocyc.org/getid?id=MetaCyc:ACETYLORNDEACET-MONOMER COG COG0624 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0624 DOI 10.1016/0378-1119(92)90621-U http://dx.doi.org/10.1016/0378-1119(92)90621-U DOI 10.1021/bi992177f http://dx.doi.org/10.1021/bi992177f DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/10.19.5935 http://dx.doi.org/10.1093/nar/10.19.5935 DOI 10.1093/nar/10.24.8031 http://dx.doi.org/10.1093/nar/10.24.8031 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.5.1.16 http://www.genome.jp/dbget-bin/www_bget?EC:3.5.1.16 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL AY330219 http://www.ebi.ac.uk/ena/data/view/AY330219 EMBL AY331711 http://www.ebi.ac.uk/ena/data/view/AY331711 EMBL J01587 http://www.ebi.ac.uk/ena/data/view/J01587 EMBL J01589 http://www.ebi.ac.uk/ena/data/view/J01589 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X55417 http://www.ebi.ac.uk/ena/data/view/X55417 EMBL X62807 http://www.ebi.ac.uk/ena/data/view/X62807 ENZYME 3.5.1.16 http://enzyme.expasy.org/EC/3.5.1.16 EchoBASE EB1263 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1263 EcoGene EG11286 http://www.ecogene.org/geneInfo.php?eg_id=EG11286 EnsemblBacteria AAC76939 http://www.ensemblgenomes.org/id/AAC76939 EnsemblBacteria AAC76939 http://www.ensemblgenomes.org/id/AAC76939 EnsemblBacteria BAE77354 http://www.ensemblgenomes.org/id/BAE77354 EnsemblBacteria BAE77354 http://www.ensemblgenomes.org/id/BAE77354 EnsemblBacteria BAE77354 http://www.ensemblgenomes.org/id/BAE77354 EnsemblBacteria b3957 http://www.ensemblgenomes.org/id/b3957 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0008237 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008237 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0008777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008777 GO_function GO:0050897 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050897 GO_process GO:0006526 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006526 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.30.70.360 http://www.cathdb.info/version/latest/superfamily/3.30.70.360 GeneID 948456 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948456 HAMAP MF_01108 http://hamap.expasy.org/unirule/MF_01108 HOGENOM HOG000243769 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000243769&db=HOGENOM6 InParanoid P23908 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23908 IntEnz 3.5.1.16 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.1.16 InterPro IPR001261 http://www.ebi.ac.uk/interpro/entry/IPR001261 InterPro IPR002933 http://www.ebi.ac.uk/interpro/entry/IPR002933 InterPro IPR010169 http://www.ebi.ac.uk/interpro/entry/IPR010169 InterPro IPR011650 http://www.ebi.ac.uk/interpro/entry/IPR011650 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3929 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3929 KEGG_Gene eco:b3957 http://www.genome.jp/dbget-bin/www_bget?eco:b3957 KEGG_Orthology KO:K01438 http://www.genome.jp/dbget-bin/www_bget?KO:K01438 KEGG_Pathway ko00330 http://www.genome.jp/kegg-bin/show_pathway?ko00330 KEGG_Reaction rn:R00669 http://www.genome.jp/dbget-bin/www_bget?rn:R00669 KEGG_Reaction rn:R09107 http://www.genome.jp/dbget-bin/www_bget?rn:R09107 OMA GTEAPYL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GTEAPYL PROSITE PS00758 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00758 PROSITE PS00759 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00759 PSORT swissprot:ARGE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARGE_ECOLI PSORT-B swissprot:ARGE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARGE_ECOLI PSORT2 swissprot:ARGE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARGE_ECOLI Pfam PF01546 http://pfam.xfam.org/family/PF01546 Pfam PF07687 http://pfam.xfam.org/family/PF07687 Phobius swissprot:ARGE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARGE_ECOLI PhylomeDB P23908 http://phylomedb.org/?seqid=P23908 ProteinModelPortal P23908 http://www.proteinmodelportal.org/query/uniprot/P23908 PubMed 10684608 http://www.ncbi.nlm.nih.gov/pubmed/10684608 PubMed 1551850 http://www.ncbi.nlm.nih.gov/pubmed/1551850 PubMed 1628835 http://www.ncbi.nlm.nih.gov/pubmed/1628835 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6292860 http://www.ncbi.nlm.nih.gov/pubmed/6292860 PubMed 6761650 http://www.ncbi.nlm.nih.gov/pubmed/6761650 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418392 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418392 RefSeq WP_001298964 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001298964 SMR P23908 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P23908 STRING 511145.b3957 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3957&targetmode=cogs STRING COG0624 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0624&targetmode=cogs SUPFAM SSF55031 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55031 TIGRFAMs TIGR01892 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01892 UniProtKB ARGE_ECOLI http://www.uniprot.org/uniprot/ARGE_ECOLI UniProtKB-AC P23908 http://www.uniprot.org/uniprot/P23908 charge swissprot:ARGE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARGE_ECOLI eggNOG COG0624 http://eggnogapi.embl.de/nog_data/html/tree/COG0624 eggNOG ENOG4105CWC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CWC epestfind swissprot:ARGE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARGE_ECOLI garnier swissprot:ARGE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARGE_ECOLI helixturnhelix swissprot:ARGE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARGE_ECOLI hmoment swissprot:ARGE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARGE_ECOLI iep swissprot:ARGE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARGE_ECOLI inforesidue swissprot:ARGE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARGE_ECOLI octanol swissprot:ARGE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARGE_ECOLI pepcoil swissprot:ARGE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARGE_ECOLI pepdigest swissprot:ARGE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARGE_ECOLI pepinfo swissprot:ARGE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARGE_ECOLI pepnet swissprot:ARGE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARGE_ECOLI pepstats swissprot:ARGE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARGE_ECOLI pepwheel swissprot:ARGE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARGE_ECOLI pepwindow swissprot:ARGE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARGE_ECOLI sigcleave swissprot:ARGE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARGE_ECOLI ## Database ID URL or Descriptions # BioGrid 4259783 7 # EcoGene EG13553 yagN # Organism YAGN_ECOLI Escherichia coli (strain K12) # PIR H64753 H64753 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAGN_ECOLI Uncharacterized protein YagN # RefSeq NP_414814 NC_000913.3 # RefSeq WP_000224818 NZ_LN832404.1 # eggNOG ENOG410792U Bacteria # eggNOG ENOG410Z1XH LUCA BLAST swissprot:YAGN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAGN_ECOLI BioCyc ECOL316407:JW0274-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0274-MONOMER BioCyc EcoCyc:G6151-MONOMER http://biocyc.org/getid?id=EcoCyc:G6151-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB3323 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3323 EcoGene EG13553 http://www.ecogene.org/geneInfo.php?eg_id=EG13553 EnsemblBacteria AAC73383 http://www.ensemblgenomes.org/id/AAC73383 EnsemblBacteria AAC73383 http://www.ensemblgenomes.org/id/AAC73383 EnsemblBacteria BAE76064 http://www.ensemblgenomes.org/id/BAE76064 EnsemblBacteria BAE76064 http://www.ensemblgenomes.org/id/BAE76064 EnsemblBacteria BAE76064 http://www.ensemblgenomes.org/id/BAE76064 EnsemblBacteria b0280 http://www.ensemblgenomes.org/id/b0280 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945349 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945349 IntAct P71297 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P71297* KEGG_Gene ecj:JW0274 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0274 KEGG_Gene eco:b0280 http://www.genome.jp/dbget-bin/www_bget?eco:b0280 PSORT swissprot:YAGN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAGN_ECOLI PSORT-B swissprot:YAGN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAGN_ECOLI PSORT2 swissprot:YAGN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAGN_ECOLI Phobius swissprot:YAGN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAGN_ECOLI ProteinModelPortal P71297 http://www.proteinmodelportal.org/query/uniprot/P71297 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414814 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414814 RefSeq WP_000224818 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000224818 STRING 511145.b0280 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0280&targetmode=cogs UniProtKB YAGN_ECOLI http://www.uniprot.org/uniprot/YAGN_ECOLI UniProtKB-AC P71297 http://www.uniprot.org/uniprot/P71297 charge swissprot:YAGN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAGN_ECOLI eggNOG ENOG410792U http://eggnogapi.embl.de/nog_data/html/tree/ENOG410792U eggNOG ENOG410Z1XH http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Z1XH epestfind swissprot:YAGN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAGN_ECOLI garnier swissprot:YAGN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAGN_ECOLI helixturnhelix swissprot:YAGN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAGN_ECOLI hmoment swissprot:YAGN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAGN_ECOLI iep swissprot:YAGN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAGN_ECOLI inforesidue swissprot:YAGN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAGN_ECOLI octanol swissprot:YAGN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAGN_ECOLI pepcoil swissprot:YAGN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAGN_ECOLI pepdigest swissprot:YAGN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAGN_ECOLI pepinfo swissprot:YAGN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAGN_ECOLI pepnet swissprot:YAGN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAGN_ECOLI pepstats swissprot:YAGN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAGN_ECOLI pepwheel swissprot:YAGN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAGN_ECOLI pepwindow swissprot:YAGN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAGN_ECOLI sigcleave swissprot:YAGN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAGN_ECOLI ## Database ID URL or Descriptions # BioGrid 4262973 16 # EcoGene EG12123 lrhA # FUNCTION LRHA_ECOLI Not known, does not seem to act on the proton translocating NADH dehydrogenase genes (nuoA-N) which are part of the lrhA operon. # GO_function GO:0000986 bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding; IDA:EcoCyc. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0043565 sequence-specific DNA binding; IDA:EcoliWiki. # GO_process GO:0006351 transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IMP:EcoCyc. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IEP:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR005119 LysR_subst-bd # InterPro IPR011991 WHTH_DNA-bd_dom # Organism LRHA_ECOLI Escherichia coli (strain K12) # PATRIC 32119945 VBIEscCol129921_2382 # PIR G65000 G65000 # PRINTS PR00039 HTHLYSR # PROSITE PS50931 HTH_LYSR # Pfam PF00126 HTH_1 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LRHA_ECOLI Probable HTH-type transcriptional regulator LrhA # RefSeq NP_416792 NC_000913.3 # RefSeq WP_000622280 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lysR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00253}. # SUPFAM SSF46785 SSF46785 # eggNOG ENOG4107NQ8 Bacteria # eggNOG ENOG410XR9D LUCA BLAST swissprot:LRHA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LRHA_ECOLI BioCyc ECOL316407:JW2284-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2284-MONOMER BioCyc EcoCyc:EG12123-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12123-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1365-2958.1995.tb02416.x http://dx.doi.org/10.1111/j.1365-2958.1995.tb02416.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X74546 http://www.ebi.ac.uk/ena/data/view/X74546 EchoBASE EB2044 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2044 EcoGene EG12123 http://www.ecogene.org/geneInfo.php?eg_id=EG12123 EnsemblBacteria AAC75349 http://www.ensemblgenomes.org/id/AAC75349 EnsemblBacteria AAC75349 http://www.ensemblgenomes.org/id/AAC75349 EnsemblBacteria BAA16124 http://www.ensemblgenomes.org/id/BAA16124 EnsemblBacteria BAA16124 http://www.ensemblgenomes.org/id/BAA16124 EnsemblBacteria BAA16124 http://www.ensemblgenomes.org/id/BAA16124 EnsemblBacteria b2289 http://www.ensemblgenomes.org/id/b2289 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000986 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000986 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 946769 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946769 HOGENOM HOG000233517 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000233517&db=HOGENOM6 InParanoid P36771 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P36771 IntAct P36771 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P36771* InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW2284 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2284 KEGG_Gene eco:b2289 http://www.genome.jp/dbget-bin/www_bget?eco:b2289 OMA ASLEAPC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ASLEAPC PRINTS PR00039 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00039 PROSITE PS50931 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50931 PSORT swissprot:LRHA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LRHA_ECOLI PSORT-B swissprot:LRHA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LRHA_ECOLI PSORT2 swissprot:LRHA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LRHA_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:LRHA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LRHA_ECOLI PhylomeDB P36771 http://phylomedb.org/?seqid=P36771 ProteinModelPortal P36771 http://www.proteinmodelportal.org/query/uniprot/P36771 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7565112 http://www.ncbi.nlm.nih.gov/pubmed/7565112 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416792 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416792 RefSeq WP_000622280 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000622280 SMR P36771 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P36771 STRING 511145.b2289 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2289&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB LRHA_ECOLI http://www.uniprot.org/uniprot/LRHA_ECOLI UniProtKB-AC P36771 http://www.uniprot.org/uniprot/P36771 charge swissprot:LRHA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LRHA_ECOLI eggNOG ENOG4107NQ8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107NQ8 eggNOG ENOG410XR9D http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XR9D epestfind swissprot:LRHA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LRHA_ECOLI garnier swissprot:LRHA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LRHA_ECOLI helixturnhelix swissprot:LRHA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LRHA_ECOLI hmoment swissprot:LRHA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LRHA_ECOLI iep swissprot:LRHA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LRHA_ECOLI inforesidue swissprot:LRHA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LRHA_ECOLI octanol swissprot:LRHA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LRHA_ECOLI pepcoil swissprot:LRHA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LRHA_ECOLI pepdigest swissprot:LRHA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LRHA_ECOLI pepinfo swissprot:LRHA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LRHA_ECOLI pepnet swissprot:LRHA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LRHA_ECOLI pepstats swissprot:LRHA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LRHA_ECOLI pepwheel swissprot:LRHA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LRHA_ECOLI pepwindow swissprot:LRHA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LRHA_ECOLI sigcleave swissprot:LRHA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LRHA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259216 4 # EcoGene EG13518 ypjB # IntAct P76612 8 # InterPro IPR020228 Uncharacterised_YpjB # Organism YPJB_ECOLI Escherichia coli (strain K12) # PATRIC 48664708 VBIEscCol107702_2681 # PIR C65044 C65044 # ProDom PD114157 Uncharacterised_YpjB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YPJB_ECOLI Uncharacterized protein YpjB # RefSeq WP_000445897 NZ_LN832404.1 BLAST swissprot:YPJB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YPJB_ECOLI BioCyc ECOL316407:JW2629-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2629-MONOMER BioCyc EcoCyc:G7384-MONOMER http://biocyc.org/getid?id=EcoCyc:G7384-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3291 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3291 EcoGene EG13518 http://www.ecogene.org/geneInfo.php?eg_id=EG13518 EnsemblBacteria BAE76775 http://www.ensemblgenomes.org/id/BAE76775 EnsemblBacteria BAE76775 http://www.ensemblgenomes.org/id/BAE76775 EnsemblBacteria BAE76775 http://www.ensemblgenomes.org/id/BAE76775 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv IntAct P76612 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76612* InterPro IPR020228 http://www.ebi.ac.uk/interpro/entry/IPR020228 KEGG_Gene ecj:JW2629 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2629 OMA FLNQISN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FLNQISN PSORT swissprot:YPJB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YPJB_ECOLI PSORT-B swissprot:YPJB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YPJB_ECOLI PSORT2 swissprot:YPJB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YPJB_ECOLI Phobius swissprot:YPJB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YPJB_ECOLI ProteinModelPortal P76612 http://www.proteinmodelportal.org/query/uniprot/P76612 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000445897 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000445897 STRING 316407.85675507 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85675507&targetmode=cogs UniProtKB YPJB_ECOLI http://www.uniprot.org/uniprot/YPJB_ECOLI UniProtKB-AC P76612 http://www.uniprot.org/uniprot/P76612 charge swissprot:YPJB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YPJB_ECOLI epestfind swissprot:YPJB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YPJB_ECOLI garnier swissprot:YPJB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YPJB_ECOLI helixturnhelix swissprot:YPJB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YPJB_ECOLI hmoment swissprot:YPJB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YPJB_ECOLI iep swissprot:YPJB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YPJB_ECOLI inforesidue swissprot:YPJB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YPJB_ECOLI octanol swissprot:YPJB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YPJB_ECOLI pepcoil swissprot:YPJB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YPJB_ECOLI pepdigest swissprot:YPJB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YPJB_ECOLI pepinfo swissprot:YPJB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YPJB_ECOLI pepnet swissprot:YPJB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YPJB_ECOLI pepstats swissprot:YPJB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YPJB_ECOLI pepwheel swissprot:YPJB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YPJB_ECOLI pepwindow swissprot:YPJB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YPJB_ECOLI sigcleave swissprot:YPJB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YPJB_ECOLI ## Database ID URL or Descriptions # AltName RSUA_ECOLI 16S pseudouridylate 516 synthase # AltName RSUA_ECOLI 16S rRNA pseudouridine(516) synthase # AltName RSUA_ECOLI rRNA pseudouridylate synthase A # AltName RSUA_ECOLI rRNA-uridine isomerase A # BRENDA 5.4.99.19 2026 # BioGrid 4260474 7 # CATALYTIC ACTIVITY RSUA_ECOLI 16S rRNA uridine(516) = 16S rRNA pseudouridine(516). {ECO 0000269|PubMed 10376875, ECO 0000269|PubMed 7612632}. # EcoGene EG12044 rsuA # FUNCTION RSUA_ECOLI Responsible for synthesis of pseudouridine from uracil- 516 in 16S ribosomal RNA. {ECO 0000269|PubMed 10376875, ECO 0000269|PubMed 7612632}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003723 RNA binding; IEA:UniProtKB-KW. # GO_function GO:0009982 pseudouridine synthase activity; IDA:EcoCyc. # GO_process GO:0000455 enzyme-directed rRNA pseudouridine synthesis; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.10.290.10 -; 1. # INTERACTION RSUA_ECOLI P0A7R5 rpsJ; NbExp=2; IntAct=EBI-557810, EBI-544602; # IntAct P0AA43 40 # InterPro IPR000748 PsdUridine_synth_RsuA/RluB/E/F # InterPro IPR002942 S4_RNA-bd # InterPro IPR006145 PsdUridine_synth_RsuA/RluD # InterPro IPR018496 PsdUridine_synth_RsuA/RluB_CS # InterPro IPR020103 PsdUridine_synth_cat_dom # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # Organism RSUA_ECOLI Escherichia coli (strain K12) # PATRIC 32119721 VBIEscCol129921_2271 # PDB 1KSK X-ray; 2.00 A; A=1-231 # PDB 1KSL X-ray; 2.10 A; A=1-231 # PDB 1KSV X-ray; 2.65 A; A=1-231 # PIR F64987 F64987 # PROSITE PS01149 PSI_RSU # PROSITE PS50889 S4 # Pfam PF00849 PseudoU_synth_2 # Pfam PF01479 S4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RSUA_ECOLI Ribosomal small subunit pseudouridine synthase A # RefSeq NP_416688 NC_000913.3 # RefSeq WP_001234850 NZ_LN832404.1 # SIMILARITY Belongs to the pseudouridine synthase RsuA family. {ECO 0000305}. # SIMILARITY Contains 1 S4 RNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00182}. # SMART SM00363 S4 # SUBUNIT RSUA_ECOLI Monomer. # SUPFAM SSF55120 SSF55120 # TIGRFAMs TIGR00093 TIGR00093 # eggNOG COG1187 LUCA # eggNOG ENOG4105I08 Bacteria BLAST swissprot:RSUA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RSUA_ECOLI BioCyc ECOL316407:JW2171-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2171-MONOMER BioCyc EcoCyc:EG12044-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12044-MONOMER BioCyc MetaCyc:EG12044-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12044-MONOMER COG COG1187 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1187 DIP DIP-35902N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35902N DOI 10.1017/S1355838299990167 http://dx.doi.org/10.1017/S1355838299990167 DOI 10.1021/bi00027a043 http://dx.doi.org/10.1021/bi00027a043 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb788 http://dx.doi.org/10.1038/nsb788 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.4.99.19 http://www.genome.jp/dbget-bin/www_bget?EC:5.4.99.19 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00008 http://www.ebi.ac.uk/ena/data/view/U00008 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 5.4.99.19 http://enzyme.expasy.org/EC/5.4.99.19 EchoBASE EB1978 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1978 EcoGene EG12044 http://www.ecogene.org/geneInfo.php?eg_id=EG12044 EnsemblBacteria AAC75244 http://www.ensemblgenomes.org/id/AAC75244 EnsemblBacteria AAC75244 http://www.ensemblgenomes.org/id/AAC75244 EnsemblBacteria BAE76648 http://www.ensemblgenomes.org/id/BAE76648 EnsemblBacteria BAE76648 http://www.ensemblgenomes.org/id/BAE76648 EnsemblBacteria BAE76648 http://www.ensemblgenomes.org/id/BAE76648 EnsemblBacteria b2183 http://www.ensemblgenomes.org/id/b2183 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0009982 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009982 GO_process GO:0000455 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000455 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.10.290.10 http://www.cathdb.info/version/latest/superfamily/3.10.290.10 GeneID 945378 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945378 HOGENOM HOG000044954 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000044954&db=HOGENOM6 InParanoid P0AA43 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AA43 IntAct P0AA43 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AA43* IntEnz 5.4.99.19 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.4.99.19 InterPro IPR000748 http://www.ebi.ac.uk/interpro/entry/IPR000748 InterPro IPR002942 http://www.ebi.ac.uk/interpro/entry/IPR002942 InterPro IPR006145 http://www.ebi.ac.uk/interpro/entry/IPR006145 InterPro IPR018496 http://www.ebi.ac.uk/interpro/entry/IPR018496 InterPro IPR020103 http://www.ebi.ac.uk/interpro/entry/IPR020103 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW2171 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2171 KEGG_Gene eco:b2183 http://www.genome.jp/dbget-bin/www_bget?eco:b2183 KEGG_Orthology KO:K06183 http://www.genome.jp/dbget-bin/www_bget?KO:K06183 MINT MINT-1221744 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1221744 OMA VQGLHRE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VQGLHRE PDB 1KSK http://www.ebi.ac.uk/pdbe-srv/view/entry/1KSK PDB 1KSL http://www.ebi.ac.uk/pdbe-srv/view/entry/1KSL PDB 1KSV http://www.ebi.ac.uk/pdbe-srv/view/entry/1KSV PDBsum 1KSK http://www.ebi.ac.uk/pdbsum/1KSK PDBsum 1KSL http://www.ebi.ac.uk/pdbsum/1KSL PDBsum 1KSV http://www.ebi.ac.uk/pdbsum/1KSV PROSITE PS01149 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01149 PROSITE PS50889 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50889 PSORT swissprot:RSUA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RSUA_ECOLI PSORT-B swissprot:RSUA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RSUA_ECOLI PSORT2 swissprot:RSUA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RSUA_ECOLI Pfam PF00849 http://pfam.xfam.org/family/PF00849 Pfam PF01479 http://pfam.xfam.org/family/PF01479 Phobius swissprot:RSUA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RSUA_ECOLI PhylomeDB P0AA43 http://phylomedb.org/?seqid=P0AA43 ProteinModelPortal P0AA43 http://www.proteinmodelportal.org/query/uniprot/P0AA43 PubMed 10376875 http://www.ncbi.nlm.nih.gov/pubmed/10376875 PubMed 11953756 http://www.ncbi.nlm.nih.gov/pubmed/11953756 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7612632 http://www.ncbi.nlm.nih.gov/pubmed/7612632 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416688 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416688 RefSeq WP_001234850 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001234850 SMART SM00363 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00363 SMR P0AA43 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AA43 STRING 511145.b2183 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2183&targetmode=cogs STRING COG1187 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1187&targetmode=cogs SUPFAM SSF55120 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55120 SWISS-2DPAGE P0AA43 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AA43 TIGRFAMs TIGR00093 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00093 UniProtKB RSUA_ECOLI http://www.uniprot.org/uniprot/RSUA_ECOLI UniProtKB-AC P0AA43 http://www.uniprot.org/uniprot/P0AA43 charge swissprot:RSUA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RSUA_ECOLI eggNOG COG1187 http://eggnogapi.embl.de/nog_data/html/tree/COG1187 eggNOG ENOG4105I08 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105I08 epestfind swissprot:RSUA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RSUA_ECOLI garnier swissprot:RSUA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RSUA_ECOLI helixturnhelix swissprot:RSUA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RSUA_ECOLI hmoment swissprot:RSUA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RSUA_ECOLI iep swissprot:RSUA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RSUA_ECOLI inforesidue swissprot:RSUA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RSUA_ECOLI octanol swissprot:RSUA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RSUA_ECOLI pepcoil swissprot:RSUA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RSUA_ECOLI pepdigest swissprot:RSUA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RSUA_ECOLI pepinfo swissprot:RSUA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RSUA_ECOLI pepnet swissprot:RSUA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RSUA_ECOLI pepstats swissprot:RSUA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RSUA_ECOLI pepwheel swissprot:RSUA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RSUA_ECOLI pepwindow swissprot:RSUA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RSUA_ECOLI sigcleave swissprot:RSUA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RSUA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262036 5 # COFACTOR YDJL_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000250}; Note=Binds 2 Zn(2+) ions per subunit. {ECO 0000250}; # EcoGene EG13488 ydjL # GO_function GO:0008270 zinc ion binding; IEA:InterPro. # GO_function GO:0016491 oxidoreductase activity; IEA:UniProtKB-KW. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.720 -; 1. # Gene3D 3.90.180.10 -; 1. # InterPro IPR002085 ADH_SF_Zn-type # InterPro IPR002328 ADH_Zn_CS # InterPro IPR011032 GroES-like # InterPro IPR013149 ADH_C # InterPro IPR013154 ADH_N # InterPro IPR016040 NAD(P)-bd_dom # Organism YDJL_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11695 PTHR11695 # PATRIC 32118863 VBIEscCol129921_1849 # PIR H64937 H64937 # PROSITE PS00059 ADH_ZINC # Pfam PF00107 ADH_zinc_N # Pfam PF08240 ADH_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDJL_ECOLI Uncharacterized zinc-type alcohol dehydrogenase-like protein YdjL # RefSeq NP_416290 NC_000913.3 # RefSeq WP_000645221 NZ_LN832404.1 # SIMILARITY Belongs to the zinc-containing alcohol dehydrogenase family. {ECO 0000305}. # SUPFAM SSF50129 SSF50129 # SUPFAM SSF51735 SSF51735 # eggNOG COG1063 LUCA # eggNOG ENOG4105CPQ Bacteria BLAST swissprot:YDJL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDJL_ECOLI BioCyc ECOL316407:JW1765-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1765-MONOMER BioCyc EcoCyc:G6963-MONOMER http://biocyc.org/getid?id=EcoCyc:G6963-MONOMER DIP DIP-11774N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11774N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- EchoBASE EB3261 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3261 EcoGene EG13488 http://www.ecogene.org/geneInfo.php?eg_id=EG13488 EnsemblBacteria AAC74846 http://www.ensemblgenomes.org/id/AAC74846 EnsemblBacteria AAC74846 http://www.ensemblgenomes.org/id/AAC74846 EnsemblBacteria BAA15574 http://www.ensemblgenomes.org/id/BAA15574 EnsemblBacteria BAA15574 http://www.ensemblgenomes.org/id/BAA15574 EnsemblBacteria BAA15574 http://www.ensemblgenomes.org/id/BAA15574 EnsemblBacteria b1776 http://www.ensemblgenomes.org/id/b1776 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 Gene3D 3.90.180.10 http://www.cathdb.info/version/latest/superfamily/3.90.180.10 GeneID 946299 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946299 HOGENOM HOG000294686 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000294686&db=HOGENOM6 InParanoid P77539 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77539 IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR002085 http://www.ebi.ac.uk/interpro/entry/IPR002085 InterPro IPR002328 http://www.ebi.ac.uk/interpro/entry/IPR002328 InterPro IPR011032 http://www.ebi.ac.uk/interpro/entry/IPR011032 InterPro IPR013149 http://www.ebi.ac.uk/interpro/entry/IPR013149 InterPro IPR013154 http://www.ebi.ac.uk/interpro/entry/IPR013154 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 KEGG_Gene ecj:JW1765 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1765 KEGG_Gene eco:b1776 http://www.genome.jp/dbget-bin/www_bget?eco:b1776 OMA FETCEEC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FETCEEC PANTHER PTHR11695 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11695 PROSITE PS00059 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00059 PSORT swissprot:YDJL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDJL_ECOLI PSORT-B swissprot:YDJL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDJL_ECOLI PSORT2 swissprot:YDJL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDJL_ECOLI Pfam PF00107 http://pfam.xfam.org/family/PF00107 Pfam PF08240 http://pfam.xfam.org/family/PF08240 Phobius swissprot:YDJL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDJL_ECOLI PhylomeDB P77539 http://phylomedb.org/?seqid=P77539 ProteinModelPortal P77539 http://www.proteinmodelportal.org/query/uniprot/P77539 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416290 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416290 RefSeq WP_000645221 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000645221 STRING 511145.b1776 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1776&targetmode=cogs SUPFAM SSF50129 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50129 SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB YDJL_ECOLI http://www.uniprot.org/uniprot/YDJL_ECOLI UniProtKB-AC P77539 http://www.uniprot.org/uniprot/P77539 charge swissprot:YDJL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDJL_ECOLI eggNOG COG1063 http://eggnogapi.embl.de/nog_data/html/tree/COG1063 eggNOG ENOG4105CPQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CPQ epestfind swissprot:YDJL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDJL_ECOLI garnier swissprot:YDJL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDJL_ECOLI helixturnhelix swissprot:YDJL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDJL_ECOLI hmoment swissprot:YDJL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDJL_ECOLI iep swissprot:YDJL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDJL_ECOLI inforesidue swissprot:YDJL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDJL_ECOLI octanol swissprot:YDJL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDJL_ECOLI pepcoil swissprot:YDJL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDJL_ECOLI pepdigest swissprot:YDJL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDJL_ECOLI pepinfo swissprot:YDJL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDJL_ECOLI pepnet swissprot:YDJL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDJL_ECOLI pepstats swissprot:YDJL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDJL_ECOLI pepwheel swissprot:YDJL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDJL_ECOLI pepwindow swissprot:YDJL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDJL_ECOLI sigcleave swissprot:YDJL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDJL_ECOLI ## Database ID URL or Descriptions # AltName DACC_ECOLI Penicillin-binding protein 6 # BioGrid 4262825 212 # CATALYTIC ACTIVITY Preferential cleavage (Ac)(2)-L-Lys-D-Ala-|- D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine. # DOMAIN DACC_ECOLI The C-terminus forms an amphiphilic helix that targets the protein to the periplasmic side of the inner cell membrane. {ECO 0000269|PubMed 3330754}. # DrugBank DB00274 Cefmetazole # DrugBank DB00303 Ertapenem # DrugBank DB00430 Cefpiramide # DrugBank DB01329 Cefoperazone # DrugBank DB01331 Cefoxitin # EcoGene EG10203 dacC # FUNCTION DACC_ECOLI Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoliWiki. # GO_function GO:0004175 endopeptidase activity; IBA:GO_Central. # GO_function GO:0004180 carboxypeptidase activity; IDA:EcoCyc. # GO_function GO:0008658 penicillin binding; IDA:EcoCyc. # GO_function GO:0009002 serine-type D-Ala-D-Ala carboxypeptidase activity; IBA:GO_Central. # GO_process GO:0008360 regulation of cell shape; IGI:EcoCyc. # GO_process GO:0009252 peptidoglycan biosynthetic process; IDA:EcoCyc. # GO_process GO:0042493 response to drug; IMP:EcoCyc. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 2.60.410.10 -; 1. # Gene3D 3.40.710.10 -; 1. # IntAct P08506 2 # InterPro IPR001967 Peptidase_S11_N # InterPro IPR012338 Beta-lactam/transpept-like # InterPro IPR012907 Peptidase_S11_C # InterPro IPR015956 Peniciliin-bd_prot-assoc # InterPro IPR018044 Peptidase_S11 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # KEGG_Pathway ko00550 Peptidoglycan biosynthesis # Organism DACC_ECOLI Escherichia coli (strain K12) # PATHWAY DACC_ECOLI Cell wall biogenesis; peptidoglycan biosynthesis. # PATRIC 32116881 VBIEscCol129921_0866 # PDB 3IT9 X-ray; 2.10 A; A/B/C/D=28-378 # PDB 3ITA X-ray; 1.80 A; A/B/C/D=28-378 # PDB 3ITB X-ray; 1.80 A; A/B/C/D=28-378 # PIR G64821 G64821 # PRINTS PR00725 DADACBPTASE1 # Pfam PF00768 Peptidase_S11 # Pfam PF07943 PBP5_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DACC_ECOLI D-alanyl-D-alanine carboxypeptidase DacC # RefSeq NP_415360 NC_000913.3 # RefSeq WP_001300708 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase S11 family. {ECO 0000305}. # SMART SM00936 PBP5_C # SUBCELLULAR LOCATION DACC_ECOLI Cell inner membrane {ECO 0000269|PubMed 3330754}; Peripheral membrane protein {ECO 0000269|PubMed 3330754}; Periplasmic side {ECO 0000269|PubMed 3330754}. Note=N-terminus lies in the periplasmic space, targeted there by the C-terminal amphiphilic helix (PMID 3330754). # SUPFAM SSF56601 SSF56601 # SUPFAM SSF69189 SSF69189 # eggNOG COG1686 LUCA # eggNOG ENOG4105DZ1 Bacteria BLAST swissprot:DACC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DACC_ECOLI BioCyc ECOL316407:JW0823-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0823-MONOMER BioCyc EcoCyc:EG10203-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10203-MONOMER BioCyc MetaCyc:EG10203-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10203-MONOMER COG COG1686 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1686 DOI 10.1016/0014-5793(82)80840-5 http://dx.doi.org/10.1016/0014-5793(82)80840-5 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/16.4.1617 http://dx.doi.org/10.1093/nar/16.4.1617 DOI 10.1111/j.1365-2958.1987.tb00522.x http://dx.doi.org/10.1111/j.1365-2958.1987.tb00522.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB00274 http://www.drugbank.ca/drugs/DB00274 DrugBank DB00303 http://www.drugbank.ca/drugs/DB00303 DrugBank DB00430 http://www.drugbank.ca/drugs/DB00430 DrugBank DB01329 http://www.drugbank.ca/drugs/DB01329 DrugBank DB01331 http://www.drugbank.ca/drugs/DB01331 EC_number EC:3.4.16.4 http://www.genome.jp/dbget-bin/www_bget?EC:3.4.16.4 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X06480 http://www.ebi.ac.uk/ena/data/view/X06480 ENZYME 3.4.16.4 http://enzyme.expasy.org/EC/3.4.16.4 EchoBASE EB0199 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0199 EcoGene EG10203 http://www.ecogene.org/geneInfo.php?eg_id=EG10203 EnsemblBacteria AAC73926 http://www.ensemblgenomes.org/id/AAC73926 EnsemblBacteria AAC73926 http://www.ensemblgenomes.org/id/AAC73926 EnsemblBacteria BAA35542 http://www.ensemblgenomes.org/id/BAA35542 EnsemblBacteria BAA35542 http://www.ensemblgenomes.org/id/BAA35542 EnsemblBacteria BAA35542 http://www.ensemblgenomes.org/id/BAA35542 EnsemblBacteria b0839 http://www.ensemblgenomes.org/id/b0839 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0004175 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004175 GO_function GO:0004180 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004180 GO_function GO:0008658 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008658 GO_function GO:0009002 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009002 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0009252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009252 GO_process GO:0042493 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 2.60.410.10 http://www.cathdb.info/version/latest/superfamily/2.60.410.10 Gene3D 3.40.710.10 http://www.cathdb.info/version/latest/superfamily/3.40.710.10 GeneID 945455 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945455 HOGENOM HOG000086623 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000086623&db=HOGENOM6 InParanoid P08506 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P08506 IntAct P08506 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P08506* IntEnz 3.4.16.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.16.4 InterPro IPR001967 http://www.ebi.ac.uk/interpro/entry/IPR001967 InterPro IPR012338 http://www.ebi.ac.uk/interpro/entry/IPR012338 InterPro IPR012907 http://www.ebi.ac.uk/interpro/entry/IPR012907 InterPro IPR015956 http://www.ebi.ac.uk/interpro/entry/IPR015956 InterPro IPR018044 http://www.ebi.ac.uk/interpro/entry/IPR018044 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW0823 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0823 KEGG_Gene eco:b0839 http://www.genome.jp/dbget-bin/www_bget?eco:b0839 KEGG_Orthology KO:K07258 http://www.genome.jp/dbget-bin/www_bget?KO:K07258 KEGG_Pathway ko00550 http://www.genome.jp/kegg-bin/show_pathway?ko00550 MINT MINT-6478097 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-6478097 OMA GTIDFKL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GTIDFKL PDB 3IT9 http://www.ebi.ac.uk/pdbe-srv/view/entry/3IT9 PDB 3ITA http://www.ebi.ac.uk/pdbe-srv/view/entry/3ITA PDB 3ITB http://www.ebi.ac.uk/pdbe-srv/view/entry/3ITB PDBsum 3IT9 http://www.ebi.ac.uk/pdbsum/3IT9 PDBsum 3ITA http://www.ebi.ac.uk/pdbsum/3ITA PDBsum 3ITB http://www.ebi.ac.uk/pdbsum/3ITB PRINTS PR00725 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00725 PSORT swissprot:DACC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DACC_ECOLI PSORT-B swissprot:DACC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DACC_ECOLI PSORT2 swissprot:DACC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DACC_ECOLI Pfam PF00768 http://pfam.xfam.org/family/PF00768 Pfam PF07943 http://pfam.xfam.org/family/PF07943 Phobius swissprot:DACC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DACC_ECOLI PhylomeDB P08506 http://phylomedb.org/?seqid=P08506 ProteinModelPortal P08506 http://www.proteinmodelportal.org/query/uniprot/P08506 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3279397 http://www.ncbi.nlm.nih.gov/pubmed/3279397 PubMed 3330754 http://www.ncbi.nlm.nih.gov/pubmed/3330754 PubMed 7042389 http://www.ncbi.nlm.nih.gov/pubmed/7042389 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415360 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415360 RefSeq WP_001300708 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300708 SMART SM00936 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00936 SMR P08506 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P08506 STRING 511145.b0839 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0839&targetmode=cogs STRING COG1686 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1686&targetmode=cogs SUPFAM SSF56601 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56601 SUPFAM SSF69189 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF69189 UniProtKB DACC_ECOLI http://www.uniprot.org/uniprot/DACC_ECOLI UniProtKB-AC P08506 http://www.uniprot.org/uniprot/P08506 charge swissprot:DACC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DACC_ECOLI eggNOG COG1686 http://eggnogapi.embl.de/nog_data/html/tree/COG1686 eggNOG ENOG4105DZ1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DZ1 epestfind swissprot:DACC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DACC_ECOLI garnier swissprot:DACC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DACC_ECOLI helixturnhelix swissprot:DACC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DACC_ECOLI hmoment swissprot:DACC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DACC_ECOLI iep swissprot:DACC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DACC_ECOLI inforesidue swissprot:DACC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DACC_ECOLI octanol swissprot:DACC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DACC_ECOLI pepcoil swissprot:DACC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DACC_ECOLI pepdigest swissprot:DACC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DACC_ECOLI pepinfo swissprot:DACC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DACC_ECOLI pepnet swissprot:DACC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DACC_ECOLI pepstats swissprot:DACC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DACC_ECOLI pepwheel swissprot:DACC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DACC_ECOLI pepwindow swissprot:DACC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DACC_ECOLI sigcleave swissprot:DACC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DACC_ECOLI ## Database ID URL or Descriptions # BioGrid 4261524 160 # EcoGene EG13631 ybcO # InterPro IPR010774 DUF1364 # MISCELLANEOUS YBCO_ECOLI Encoded by the cryptic lambdoid prophage DLP12. # Organism YBCO_ECOLI Escherichia coli (strain K12) # PATRIC 32116260 VBIEscCol129921_0570 # PDB 3G27 X-ray; 2.10 A; A=1-96 # PIR C64787 C64787 # Pfam PF07102 DUF1364 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBCO_ECOLI Uncharacterized protein YbcO # RefSeq NP_415081 NC_000913.3 # RefSeq WP_000774486 NZ_LN832404.1 # eggNOG ENOG4105RWQ Bacteria # eggNOG ENOG4111WGW LUCA BLAST swissprot:YBCO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBCO_ECOLI BioCyc ECOL316407:JW0537-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0537-MONOMER BioCyc EcoCyc:G6305-MONOMER http://biocyc.org/getid?id=EcoCyc:G6305-MONOMER DOI 10.1006/jmbi.1996.0185 http://dx.doi.org/10.1006/jmbi.1996.0185 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EMBL X92587 http://www.ebi.ac.uk/ena/data/view/X92587 EchoBASE EB3396 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3396 EcoGene EG13631 http://www.ecogene.org/geneInfo.php?eg_id=EG13631 EnsemblBacteria AAC73650 http://www.ensemblgenomes.org/id/AAC73650 EnsemblBacteria AAC73650 http://www.ensemblgenomes.org/id/AAC73650 EnsemblBacteria BAE76324 http://www.ensemblgenomes.org/id/BAE76324 EnsemblBacteria BAE76324 http://www.ensemblgenomes.org/id/BAE76324 EnsemblBacteria BAE76324 http://www.ensemblgenomes.org/id/BAE76324 EnsemblBacteria b0549 http://www.ensemblgenomes.org/id/b0549 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945147 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945147 HOGENOM HOG000122769 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122769&db=HOGENOM6 IntAct P68661 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P68661* InterPro IPR010774 http://www.ebi.ac.uk/interpro/entry/IPR010774 KEGG_Gene ecj:JW0537 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0537 KEGG_Gene eco:b0549 http://www.genome.jp/dbget-bin/www_bget?eco:b0549 OMA TIACSSC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TIACSSC PDB 3G27 http://www.ebi.ac.uk/pdbe-srv/view/entry/3G27 PDBsum 3G27 http://www.ebi.ac.uk/pdbsum/3G27 PSORT swissprot:YBCO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBCO_ECOLI PSORT-B swissprot:YBCO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBCO_ECOLI PSORT2 swissprot:YBCO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBCO_ECOLI Pfam PF07102 http://pfam.xfam.org/family/PF07102 Phobius swissprot:YBCO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBCO_ECOLI ProteinModelPortal P68661 http://www.proteinmodelportal.org/query/uniprot/P68661 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8648624 http://www.ncbi.nlm.nih.gov/pubmed/8648624 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415081 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415081 RefSeq WP_000774486 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000774486 SMR P68661 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P68661 STRING 511145.b0549 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0549&targetmode=cogs UniProtKB YBCO_ECOLI http://www.uniprot.org/uniprot/YBCO_ECOLI UniProtKB-AC P68661 http://www.uniprot.org/uniprot/P68661 charge swissprot:YBCO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBCO_ECOLI eggNOG ENOG4105RWQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105RWQ eggNOG ENOG4111WGW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111WGW epestfind swissprot:YBCO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBCO_ECOLI garnier swissprot:YBCO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBCO_ECOLI helixturnhelix swissprot:YBCO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBCO_ECOLI hmoment swissprot:YBCO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBCO_ECOLI iep swissprot:YBCO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBCO_ECOLI inforesidue swissprot:YBCO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBCO_ECOLI octanol swissprot:YBCO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBCO_ECOLI pepcoil swissprot:YBCO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBCO_ECOLI pepdigest swissprot:YBCO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBCO_ECOLI pepinfo swissprot:YBCO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBCO_ECOLI pepnet swissprot:YBCO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBCO_ECOLI pepstats swissprot:YBCO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBCO_ECOLI pepwheel swissprot:YBCO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBCO_ECOLI pepwindow swissprot:YBCO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBCO_ECOLI sigcleave swissprot:YBCO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBCO_ECOLI ## Database ID URL or Descriptions # BioGrid 4261262 9 # EcoGene EG12569 yjiH # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR011642 Gate_dom # Organism YJIH_ECOLI Escherichia coli (strain K12) # PATRIC 32124262 VBIEscCol129921_4474 # Pfam PF07670 Gate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJIH_ECOLI Uncharacterized protein YjiH # RefSeq NP_418750 NC_000913.3 # RefSeq WP_001295597 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97226.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SUBCELLULAR LOCATION YJIH_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # TCDB 9.A.5.4 the putative arginine transporter (argw) family # eggNOG COG3314 LUCA # eggNOG ENOG41074DU Bacteria BLAST swissprot:YJIH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJIH_ECOLI BioCyc ECOL316407:JW5783-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5783-MONOMER BioCyc EcoCyc:G7927-MONOMER http://biocyc.org/getid?id=EcoCyc:G7927-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2457 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2457 EcoGene EG12569 http://www.ecogene.org/geneInfo.php?eg_id=EG12569 EnsemblBacteria AAC77286 http://www.ensemblgenomes.org/id/AAC77286 EnsemblBacteria AAC77286 http://www.ensemblgenomes.org/id/AAC77286 EnsemblBacteria BAE78323 http://www.ensemblgenomes.org/id/BAE78323 EnsemblBacteria BAE78323 http://www.ensemblgenomes.org/id/BAE78323 EnsemblBacteria BAE78323 http://www.ensemblgenomes.org/id/BAE78323 EnsemblBacteria b4330 http://www.ensemblgenomes.org/id/b4330 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 948856 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948856 HOGENOM HOG000111644 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000111644&db=HOGENOM6 InterPro IPR011642 http://www.ebi.ac.uk/interpro/entry/IPR011642 KEGG_Gene ecj:JW5783 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5783 KEGG_Gene eco:b4330 http://www.genome.jp/dbget-bin/www_bget?eco:b4330 OMA MFVLKFV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MFVLKFV PSORT swissprot:YJIH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJIH_ECOLI PSORT-B swissprot:YJIH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJIH_ECOLI PSORT2 swissprot:YJIH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJIH_ECOLI Pfam PF07670 http://pfam.xfam.org/family/PF07670 Phobius swissprot:YJIH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJIH_ECOLI ProteinModelPortal P39379 http://www.proteinmodelportal.org/query/uniprot/P39379 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418750 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418750 RefSeq WP_001295597 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295597 STRING 511145.b4330 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4330&targetmode=cogs TCDB 9.A.5.4 http://www.tcdb.org/search/result.php?tc=9.A.5.4 UniProtKB YJIH_ECOLI http://www.uniprot.org/uniprot/YJIH_ECOLI UniProtKB-AC P39379 http://www.uniprot.org/uniprot/P39379 charge swissprot:YJIH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJIH_ECOLI eggNOG COG3314 http://eggnogapi.embl.de/nog_data/html/tree/COG3314 eggNOG ENOG41074DU http://eggnogapi.embl.de/nog_data/html/tree/ENOG41074DU epestfind swissprot:YJIH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJIH_ECOLI garnier swissprot:YJIH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJIH_ECOLI helixturnhelix swissprot:YJIH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJIH_ECOLI hmoment swissprot:YJIH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJIH_ECOLI iep swissprot:YJIH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJIH_ECOLI inforesidue swissprot:YJIH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJIH_ECOLI octanol swissprot:YJIH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJIH_ECOLI pepcoil swissprot:YJIH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJIH_ECOLI pepdigest swissprot:YJIH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJIH_ECOLI pepinfo swissprot:YJIH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJIH_ECOLI pepnet swissprot:YJIH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJIH_ECOLI pepstats swissprot:YJIH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJIH_ECOLI pepwheel swissprot:YJIH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJIH_ECOLI pepwindow swissprot:YJIH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJIH_ECOLI sigcleave swissprot:YJIH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJIH_ECOLI ## Database ID URL or Descriptions # AltName ESSD_ECOLI Lysis protein S homolog from lambdoid prophage DLP12 # BioGrid 4259884 11 # EcoGene EG13634 essD # GO_process GO:0044659 cytolysis by virus of host cell; ISS:EcoCyc. # GOslim_process GO:0040011 locomotion # GOslim_process GO:0044403 symbiosis, encompassing mutualism through parasitism # InterPro IPR007054 Lysis_S # MISCELLANEOUS ESSD_ECOLI Encoded by the cryptic lambdoid prophage DLP12. # Organism ESSD_ECOLI Escherichia coli (strain K12) # PATRIC 32116274 VBIEscCol129921_0577 # PIR H64787 H64787 # PIRSF PIRSF030786 Lysis_S # Pfam PF04971 Phage_holin_2_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Prophage lysis protein S homolog EssD {ECO 0000305} # RefSeq NP_415086 NC_000913.3 # RefSeq WP_000839596 NZ_CP014272.1 # SIMILARITY Belongs to the lambda phage S protein family. {ECO 0000305}. # eggNOG ENOG4105QFS Bacteria # eggNOG ENOG4111XDG LUCA BLAST swissprot:ESSD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ESSD_ECOLI BioCyc ECOL316407:JW0543-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0543-MONOMER BioCyc EcoCyc:G6309-MONOMER http://biocyc.org/getid?id=EcoCyc:G6309-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB3398 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3398 EcoGene EG13634 http://www.ecogene.org/geneInfo.php?eg_id=EG13634 EnsemblBacteria AAC73655 http://www.ensemblgenomes.org/id/AAC73655 EnsemblBacteria AAC73655 http://www.ensemblgenomes.org/id/AAC73655 EnsemblBacteria BAE76329 http://www.ensemblgenomes.org/id/BAE76329 EnsemblBacteria BAE76329 http://www.ensemblgenomes.org/id/BAE76329 EnsemblBacteria BAE76329 http://www.ensemblgenomes.org/id/BAE76329 EnsemblBacteria b0554 http://www.ensemblgenomes.org/id/b0554 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0044659 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044659 GOslim_process GO:0040011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011 GOslim_process GO:0044403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403 GeneID 947545 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947545 HOGENOM HOG000120019 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120019&db=HOGENOM6 InterPro IPR007054 http://www.ebi.ac.uk/interpro/entry/IPR007054 KEGG_Gene ecj:JW0543 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0543 KEGG_Gene eco:b0554 http://www.genome.jp/dbget-bin/www_bget?eco:b0554 OMA VMKSMDK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VMKSMDK PSORT swissprot:ESSD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ESSD_ECOLI PSORT-B swissprot:ESSD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ESSD_ECOLI PSORT2 swissprot:ESSD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ESSD_ECOLI Pfam PF04971 http://pfam.xfam.org/family/PF04971 Phobius swissprot:ESSD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ESSD_ECOLI ProteinModelPortal P0A9R2 http://www.proteinmodelportal.org/query/uniprot/P0A9R2 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415086 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415086 RefSeq WP_000839596 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000839596 STRING 511145.b0554 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0554&targetmode=cogs UniProtKB ESSD_ECOLI http://www.uniprot.org/uniprot/ESSD_ECOLI UniProtKB-AC P0A9R2 http://www.uniprot.org/uniprot/P0A9R2 charge swissprot:ESSD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ESSD_ECOLI eggNOG ENOG4105QFS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105QFS eggNOG ENOG4111XDG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111XDG epestfind swissprot:ESSD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ESSD_ECOLI garnier swissprot:ESSD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ESSD_ECOLI helixturnhelix swissprot:ESSD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ESSD_ECOLI hmoment swissprot:ESSD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ESSD_ECOLI iep swissprot:ESSD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ESSD_ECOLI inforesidue swissprot:ESSD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ESSD_ECOLI octanol swissprot:ESSD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ESSD_ECOLI pepcoil swissprot:ESSD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ESSD_ECOLI pepdigest swissprot:ESSD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ESSD_ECOLI pepinfo swissprot:ESSD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ESSD_ECOLI pepnet swissprot:ESSD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ESSD_ECOLI pepstats swissprot:ESSD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ESSD_ECOLI pepwheel swissprot:ESSD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ESSD_ECOLI pepwindow swissprot:ESSD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ESSD_ECOLI sigcleave swissprot:ESSD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ESSD_ECOLI ## Database ID URL or Descriptions # AltName TUSE_ECOLI tRNA 2-thiouridine synthesizing protein E # BioGrid 4260042 10 # EcoGene EG12876 tusE # FUNCTION TUSE_ECOLI Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Could accept sulfur from TusD. {ECO 0000269|PubMed 16387657}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0016740 transferase activity; IEA:UniProtKB-KW. # GO_function GO:0097163 sulfur carrier activity; IDA:EcoCyc. # GO_process GO:0002143 tRNA wobble position uridine thiolation; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006399 tRNA metabolic process # IntAct P0AB18 11 # InterPro IPR007453 DsrC/TusE # InterPro IPR025526 DsrC-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # KEGG_Pathway ko04122 Sulfur relay system # Organism TUSE_ECOLI Escherichia coli (strain K12) # PATRIC 32117159 VBIEscCol129921_1004 # PIR H64837 H64837 # PIRSF PIRSF006223 DsrC_TusE # Pfam PF04358 DsrC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TUSE_ECOLI Sulfurtransferase TusE # RefSeq NP_415489 NC_000913.3 # RefSeq WP_000904442 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=X00547; Type=Frameshift; Positions=24; Evidence={ECO 0000305}; # SIMILARITY Belongs to the DsrC/TusE family. {ECO 0000305}. # SUBCELLULAR LOCATION TUSE_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Interacts with the TusBCD complex. Interacts with MnmA. {ECO:0000269|PubMed 16387657}. # SUPFAM SSF69721 SSF69721 # TIGRFAMs TIGR03342 dsrC_tusE_dsvC # eggNOG COG2920 LUCA # eggNOG ENOG4108Z0T Bacteria BLAST swissprot:TUSE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TUSE_ECOLI BioCyc ECOL316407:JW0952-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0952-MONOMER BioCyc EcoCyc:EG12876-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12876-MONOMER BioCyc MetaCyc:EG12876-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12876-MONOMER COG COG2920 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2920 DIP DIP-48154N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48154N DOI 10.1016/j.molcel.2005.11.001 http://dx.doi.org/10.1016/j.molcel.2005.11.001 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.8.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.8.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X00547 http://www.ebi.ac.uk/ena/data/view/X00547 ENZYME 2.8.1.- http://enzyme.expasy.org/EC/2.8.1.- EchoBASE EB2714 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2714 EcoGene EG12876 http://www.ecogene.org/geneInfo.php?eg_id=EG12876 EnsemblBacteria AAC74055 http://www.ensemblgenomes.org/id/AAC74055 EnsemblBacteria AAC74055 http://www.ensemblgenomes.org/id/AAC74055 EnsemblBacteria BAA35734 http://www.ensemblgenomes.org/id/BAA35734 EnsemblBacteria BAA35734 http://www.ensemblgenomes.org/id/BAA35734 EnsemblBacteria BAA35734 http://www.ensemblgenomes.org/id/BAA35734 EnsemblBacteria b0969 http://www.ensemblgenomes.org/id/b0969 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0016740 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016740 GO_function GO:0097163 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097163 GO_process GO:0002143 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002143 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GeneID 945023 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945023 HOGENOM HOG000279490 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000279490&db=HOGENOM6 InParanoid P0AB18 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AB18 IntAct P0AB18 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AB18* IntEnz 2.8.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.8.1 InterPro IPR007453 http://www.ebi.ac.uk/interpro/entry/IPR007453 InterPro IPR025526 http://www.ebi.ac.uk/interpro/entry/IPR025526 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW0952 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0952 KEGG_Gene eco:b0969 http://www.genome.jp/dbget-bin/www_bget?eco:b0969 KEGG_Orthology KO:K11179 http://www.genome.jp/dbget-bin/www_bget?KO:K11179 KEGG_Pathway ko04122 http://www.genome.jp/kegg-bin/show_pathway?ko04122 OMA EYNTSPA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EYNTSPA PSORT swissprot:TUSE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TUSE_ECOLI PSORT-B swissprot:TUSE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TUSE_ECOLI PSORT2 swissprot:TUSE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TUSE_ECOLI Pfam PF04358 http://pfam.xfam.org/family/PF04358 Phobius swissprot:TUSE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TUSE_ECOLI PhylomeDB P0AB18 http://phylomedb.org/?seqid=P0AB18 ProteinModelPortal P0AB18 http://www.proteinmodelportal.org/query/uniprot/P0AB18 PubMed 16387657 http://www.ncbi.nlm.nih.gov/pubmed/16387657 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6376117 http://www.ncbi.nlm.nih.gov/pubmed/6376117 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415489 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415489 RefSeq WP_000904442 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000904442 SMR P0AB18 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AB18 STRING 511145.b0969 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0969&targetmode=cogs STRING COG2920 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2920&targetmode=cogs SUPFAM SSF69721 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF69721 TIGRFAMs TIGR03342 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03342 UniProtKB TUSE_ECOLI http://www.uniprot.org/uniprot/TUSE_ECOLI UniProtKB-AC P0AB18 http://www.uniprot.org/uniprot/P0AB18 charge swissprot:TUSE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TUSE_ECOLI eggNOG COG2920 http://eggnogapi.embl.de/nog_data/html/tree/COG2920 eggNOG ENOG4108Z0T http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Z0T epestfind swissprot:TUSE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TUSE_ECOLI garnier swissprot:TUSE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TUSE_ECOLI helixturnhelix swissprot:TUSE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TUSE_ECOLI hmoment swissprot:TUSE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TUSE_ECOLI iep swissprot:TUSE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TUSE_ECOLI inforesidue swissprot:TUSE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TUSE_ECOLI octanol swissprot:TUSE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TUSE_ECOLI pepcoil swissprot:TUSE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TUSE_ECOLI pepdigest swissprot:TUSE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TUSE_ECOLI pepinfo swissprot:TUSE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TUSE_ECOLI pepnet swissprot:TUSE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TUSE_ECOLI pepstats swissprot:TUSE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TUSE_ECOLI pepwheel swissprot:TUSE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TUSE_ECOLI pepwindow swissprot:TUSE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TUSE_ECOLI sigcleave swissprot:TUSE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TUSE_ECOLI ## Database ID URL or Descriptions # AltName SLT_ECOLI Exomuramidase # AltName SLT_ECOLI Peptidoglycan lytic exotransglycosylase # AltName SLT_ECOLI Slt70 # BioGrid 4260799 185 # CATALYTIC ACTIVITY SLT_ECOLI Exolytic cleavage of the (1->4)-beta- glycosidic linkage between N-acetylmuramic acid (MurNAc) and N- acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue. # CAZy GH23 Glycoside Hydrolase Family 23 # EcoGene EG10950 slt # FUNCTION SLT_ECOLI Murein-degrading enzyme. Catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N- acetylglucosamine residues in peptidoglycan. May play a role in recycling of muropeptides during cell elongation and/or cell division. # GO_component GO:0016020 membrane; IEA:InterPro. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds; IDA:EcoCyc. # GO_function GO:0008933 lytic transglycosylase activity; IDA:EcoliWiki. # GO_function GO:0052762 gellan lyase activity; IEA:UniProtKB-EC. # GO_function GO:0052764 exo-oligoalginate lyase activity; IEA:UniProtKB-EC. # GO_process GO:0009253 peptidoglycan catabolic process; IDA:EcoCyc. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 1.10.1240.20 -; 1. # Gene3D 1.25.20.10 -; 1. # IntAct P0AGC3 5 # InterPro IPR000189 Transglyc_AS # InterPro IPR008258 Transglycosylase_SLT_dom_1 # InterPro IPR008939 Lytic_TGlycosylase_superhlx_U # InterPro IPR012289 Lytic_TGlycosylase_superhlx_L # InterPro IPR016026 Lytic_TGlyclase_suprhlx_U/L # InterPro IPR023346 Lysozyme-like_dom # KEGG_Brite ko01000 Enzymes # Organism SLT_ECOLI Escherichia coli (strain K12) # PATRIC 32124402 VBIEscCol129921_4541 # PDB 1QSA X-ray; 1.65 A; A=28-645 # PDB 1QTE X-ray; 1.90 A; A=28-645 # PDB 1SLY X-ray; 2.80 A; A=28-645 # PIR S56616 QQECW1 # PROSITE PS00922 TRANSGLYCOSYLASE # Pfam PF01464 SLT # Pfam PF14718 SLT_L # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SLT_ECOLI Soluble lytic murein transglycosylase # RefSeq NP_418809 NC_000913.3 # RefSeq WP_000409451 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97288.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the transglycosylase Slt family. {ECO 0000305}. # SUBCELLULAR LOCATION SLT_ECOLI Periplasm. Note=Tightly associated with the murein sacculus. # SUPFAM SSF48435 SSF48435 # SUPFAM SSF53955 SSF53955 # eggNOG COG0741 LUCA # eggNOG ENOG4107SC1 Bacteria BLAST swissprot:SLT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SLT_ECOLI BioCyc ECOL316407:JW4355-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4355-MONOMER BioCyc EcoCyc:EG10950-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10950-MONOMER BioCyc MetaCyc:EG10950-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10950-MONOMER COG COG0741 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0741 DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/jmbi.1999.3013 http://dx.doi.org/10.1006/jmbi.1999.3013 DOI 10.1007/BF00259625 http://dx.doi.org/10.1007/BF00259625 DOI 10.1016/0022-2836(90)90221-7 http://dx.doi.org/10.1016/0022-2836(90)90221-7 DOI 10.1021/bi00039a032 http://dx.doi.org/10.1021/bi00039a032 DOI 10.1038/367750a0 http://dx.doi.org/10.1038/367750a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.77.12.7117 http://dx.doi.org/10.1073/pnas.77.12.7117 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1093/nar/8.7.1551 http://dx.doi.org/10.1093/nar/8.7.1551 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.2.n1 http://www.genome.jp/dbget-bin/www_bget?EC:4.2.2.n1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01715 http://www.ebi.ac.uk/ena/data/view/J01715 EMBL M69185 http://www.ebi.ac.uk/ena/data/view/M69185 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 4.2.2.n1 http://enzyme.expasy.org/EC/4.2.2.n1 EchoBASE EB0943 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0943 EcoGene EG10950 http://www.ecogene.org/geneInfo.php?eg_id=EG10950 EnsemblBacteria AAC77345 http://www.ensemblgenomes.org/id/AAC77345 EnsemblBacteria AAC77345 http://www.ensemblgenomes.org/id/AAC77345 EnsemblBacteria BAE78381 http://www.ensemblgenomes.org/id/BAE78381 EnsemblBacteria BAE78381 http://www.ensemblgenomes.org/id/BAE78381 EnsemblBacteria BAE78381 http://www.ensemblgenomes.org/id/BAE78381 EnsemblBacteria b4392 http://www.ensemblgenomes.org/id/b4392 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0004553 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004553 GO_function GO:0008933 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008933 GO_function GO:0052762 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052762 GO_function GO:0052764 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052764 GO_process GO:0009253 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009253 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 1.10.1240.20 http://www.cathdb.info/version/latest/superfamily/1.10.1240.20 Gene3D 1.25.20.10 http://www.cathdb.info/version/latest/superfamily/1.25.20.10 GeneID 948908 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948908 HOGENOM HOG000275388 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275388&db=HOGENOM6 InParanoid P0AGC3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGC3 IntAct P0AGC3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AGC3* IntEnz 4.2.2.n1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.2.n1 InterPro IPR000189 http://www.ebi.ac.uk/interpro/entry/IPR000189 InterPro IPR008258 http://www.ebi.ac.uk/interpro/entry/IPR008258 InterPro IPR008939 http://www.ebi.ac.uk/interpro/entry/IPR008939 InterPro IPR012289 http://www.ebi.ac.uk/interpro/entry/IPR012289 InterPro IPR016026 http://www.ebi.ac.uk/interpro/entry/IPR016026 InterPro IPR023346 http://www.ebi.ac.uk/interpro/entry/IPR023346 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4355 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4355 KEGG_Gene eco:b4392 http://www.genome.jp/dbget-bin/www_bget?eco:b4392 KEGG_Orthology KO:K08309 http://www.genome.jp/dbget-bin/www_bget?KO:K08309 OMA VDWHERY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VDWHERY PDB 1QSA http://www.ebi.ac.uk/pdbe-srv/view/entry/1QSA PDB 1QTE http://www.ebi.ac.uk/pdbe-srv/view/entry/1QTE PDB 1SLY http://www.ebi.ac.uk/pdbe-srv/view/entry/1SLY PDBsum 1QSA http://www.ebi.ac.uk/pdbsum/1QSA PDBsum 1QTE http://www.ebi.ac.uk/pdbsum/1QTE PDBsum 1SLY http://www.ebi.ac.uk/pdbsum/1SLY PROSITE PS00922 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00922 PSORT swissprot:SLT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SLT_ECOLI PSORT-B swissprot:SLT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SLT_ECOLI PSORT2 swissprot:SLT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SLT_ECOLI Pfam PF01464 http://pfam.xfam.org/family/PF01464 Pfam PF14718 http://pfam.xfam.org/family/PF14718 Phobius swissprot:SLT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SLT_ECOLI PhylomeDB P0AGC3 http://phylomedb.org/?seqid=P0AGC3 ProteinModelPortal P0AGC3 http://www.proteinmodelportal.org/query/uniprot/P0AGC3 PubMed 10452894 http://www.ncbi.nlm.nih.gov/pubmed/10452894 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1938883 http://www.ncbi.nlm.nih.gov/pubmed/1938883 PubMed 2184239 http://www.ncbi.nlm.nih.gov/pubmed/2184239 PubMed 2695826 http://www.ncbi.nlm.nih.gov/pubmed/2695826 PubMed 7001368 http://www.ncbi.nlm.nih.gov/pubmed/7001368 PubMed 7012834 http://www.ncbi.nlm.nih.gov/pubmed/7012834 PubMed 7548026 http://www.ncbi.nlm.nih.gov/pubmed/7548026 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8107871 http://www.ncbi.nlm.nih.gov/pubmed/8107871 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_418809 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418809 RefSeq WP_000409451 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000409451 SMR P0AGC3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AGC3 STRING 511145.b4392 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4392&targetmode=cogs STRING COG0741 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0741&targetmode=cogs SUPFAM SSF48435 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48435 SUPFAM SSF53955 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53955 UniProtKB SLT_ECOLI http://www.uniprot.org/uniprot/SLT_ECOLI UniProtKB-AC P0AGC3 http://www.uniprot.org/uniprot/P0AGC3 charge swissprot:SLT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SLT_ECOLI eggNOG COG0741 http://eggnogapi.embl.de/nog_data/html/tree/COG0741 eggNOG ENOG4107SC1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107SC1 epestfind swissprot:SLT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SLT_ECOLI garnier swissprot:SLT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SLT_ECOLI helixturnhelix swissprot:SLT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SLT_ECOLI hmoment swissprot:SLT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SLT_ECOLI iep swissprot:SLT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SLT_ECOLI inforesidue swissprot:SLT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SLT_ECOLI octanol swissprot:SLT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SLT_ECOLI pepcoil swissprot:SLT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SLT_ECOLI pepdigest swissprot:SLT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SLT_ECOLI pepinfo swissprot:SLT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SLT_ECOLI pepnet swissprot:SLT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SLT_ECOLI pepstats swissprot:SLT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SLT_ECOLI pepwheel swissprot:SLT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SLT_ECOLI pepwindow swissprot:SLT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SLT_ECOLI sigcleave swissprot:SLT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SLT_ECOLI ## Database ID URL or Descriptions # BioGrid 4263061 174 # EcoGene EG10441 ihfB # FUNCTION IHFB_ECOLI Has an essential role in conjugative DNA transfer (CDT), the unidirectional transfer of ssDNA plasmid from a donor to a recipient cell. It is the central mechanism by which antibiotic resistance and virulence factors are propagated in bacterial populations. Part of the relaxosome, which facilitates a site- and strand-specific cut in the origin of transfer by TraI, at the nic site. Relaxosome formation requires binding of IHF and TraY to the oriT region, which then faciliates binding of TraI. # FUNCTION IHFB_ECOLI One of the 2 subunits of integration host factor (IHF), a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. # FUNCTION IHFB_ECOLI Plays a crucial role in the lysogenic life cycle of bacteriophage lambda, as it is required not only in the recombination reaction, which inserts lambda DNA into the E.coli chromosome, but also for the synthesis of int and cI repressor, two phage proteins necessary for DNA insertion and repression, respectively. The synthesis of int and cI proteins is regulated indirectly by IHF via translational control of the lambda cII protein. # GO_component GO:0005694 chromosome; IEA:InterPro. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-HAMAP. # GO_process GO:0000746 conjugation; IEA:UniProtKB-KW. # GO_process GO:0006310 DNA recombination; IEA:UniProtKB-HAMAP. # GO_process GO:0006351 transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0006417 regulation of translation; IEA:UniProtKB-HAMAP. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_component GO:0005694 chromosome # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 4.10.520.10 -; 1. # HAMAP MF_00381 IHF_beta # IntAct P0A6Y1 34 # InterPro IPR000119 Hist_DNA-bd # InterPro IPR005685 IHF_beta # InterPro IPR010992 IHF-like_DNA-bd_dom # InterPro IPR020816 Histone-like_DNA-bd_CS # KEGG_Brite ko03032 DNA replication proteins # KEGG_Brite ko03036 Chromosome # KEGG_Brite ko03400 DNA repair and recombination proteins # Organism IHFB_ECOLI Escherichia coli (strain K12) # PATRIC 32117037 VBIEscCol129921_0943 # PDB 1IHF X-ray; 2.20 A; B=1-94 # PDB 1OUZ X-ray; 2.41 A; B=1-94 # PDB 1OWF X-ray; 1.95 A; B=1-94 # PDB 1OWG X-ray; 2.10 A; B=1-94 # PDB 2HT0 X-ray; 2.00 A; B=1-94 # PDB 2IIE X-ray; 2.41 A; A=2-94 # PDB 2IIF X-ray; 2.72 A; A=2-94 # PIR G64830 IQECAB # PRINTS PR01727 DNABINDINGHU # PROSITE PS00045 HISTONE_LIKE # Pfam PF00216 Bac_DNA_binding # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName IHFB_ECOLI Integration host factor subunit beta # RefSeq NP_415432 NC_000913.3 # RefSeq WP_000167336 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial histone-like protein family. {ECO 0000305}. # SMART SM00411 BHL # SUBCELLULAR LOCATION IHFB_ECOLI Cytoplasm. # SUBUNIT IHFB_ECOLI Heterodimer of an alpha and a beta chain. Part of the relaxosome, a complex composed of plasmid-encoded TraI, TraM, TraY and host-encoded IHF bound to the F plasmid origin of transfer (oriT). {ECO 0000269|PubMed 17238924, ECO 0000269|PubMed 7499340}. # SUPFAM SSF47729 SSF47729 # TIGRFAMs TIGR00988 hip # eggNOG COG0776 LUCA # eggNOG ENOG41080YA Bacteria BLAST swissprot:IHFB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:IHFB_ECOLI BioCyc ECOL316407:JW0895-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0895-MONOMER BioCyc EcoCyc:PD00348 http://biocyc.org/getid?id=EcoCyc:PD00348 COG COG0776 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0776 DIP DIP-41099N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-41099N DOI 10.1016/0022-2836(85)90206-2 http://dx.doi.org/10.1016/0022-2836(85)90206-2 DOI 10.1016/S0092-8674(00)81824-3 http://dx.doi.org/10.1016/S0092-8674(00)81824-3 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.270.47.28374 http://dx.doi.org/10.1074/jbc.270.47.28374 DOI 10.1074/jbc.270.47.28381 http://dx.doi.org/10.1074/jbc.270.47.28381 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.2006.05576.x http://dx.doi.org/10.1111/j.1365-2958.2006.05576.x DOI 10.1111/j.1574-6968.1998.tb13343.x http://dx.doi.org/10.1111/j.1574-6968.1998.tb13343.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X04864 http://www.ebi.ac.uk/ena/data/view/X04864 EchoBASE EB0436 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0436 EcoGene EG10441 http://www.ecogene.org/geneInfo.php?eg_id=EG10441 EnsemblBacteria AAC73998 http://www.ensemblgenomes.org/id/AAC73998 EnsemblBacteria AAC73998 http://www.ensemblgenomes.org/id/AAC73998 EnsemblBacteria BAA35656 http://www.ensemblgenomes.org/id/BAA35656 EnsemblBacteria BAA35656 http://www.ensemblgenomes.org/id/BAA35656 EnsemblBacteria BAA35656 http://www.ensemblgenomes.org/id/BAA35656 EnsemblBacteria b0912 http://www.ensemblgenomes.org/id/b0912 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005694 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005694 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0000746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000746 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006417 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006417 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_component GO:0005694 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005694 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 4.10.520.10 http://www.cathdb.info/version/latest/superfamily/4.10.520.10 GeneID 945533 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945533 HAMAP MF_00381 http://hamap.expasy.org/unirule/MF_00381 HOGENOM HOG000043828 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000043828&db=HOGENOM6 InParanoid P0A6Y1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6Y1 IntAct P0A6Y1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6Y1* InterPro IPR000119 http://www.ebi.ac.uk/interpro/entry/IPR000119 InterPro IPR005685 http://www.ebi.ac.uk/interpro/entry/IPR005685 InterPro IPR010992 http://www.ebi.ac.uk/interpro/entry/IPR010992 InterPro IPR020816 http://www.ebi.ac.uk/interpro/entry/IPR020816 KEGG_Brite ko03032 http://www.genome.jp/dbget-bin/www_bget?ko03032 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW0895 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0895 KEGG_Gene eco:b0912 http://www.genome.jp/dbget-bin/www_bget?eco:b0912 KEGG_Orthology KO:K05788 http://www.genome.jp/dbget-bin/www_bget?KO:K05788 MINT MINT-365163 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-365163 OMA RDRVNIY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RDRVNIY PDB 1IHF http://www.ebi.ac.uk/pdbe-srv/view/entry/1IHF PDB 1OUZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1OUZ PDB 1OWF http://www.ebi.ac.uk/pdbe-srv/view/entry/1OWF PDB 1OWG http://www.ebi.ac.uk/pdbe-srv/view/entry/1OWG PDB 2HT0 http://www.ebi.ac.uk/pdbe-srv/view/entry/2HT0 PDB 2IIE http://www.ebi.ac.uk/pdbe-srv/view/entry/2IIE PDB 2IIF http://www.ebi.ac.uk/pdbe-srv/view/entry/2IIF PDBsum 1IHF http://www.ebi.ac.uk/pdbsum/1IHF PDBsum 1OUZ http://www.ebi.ac.uk/pdbsum/1OUZ PDBsum 1OWF http://www.ebi.ac.uk/pdbsum/1OWF PDBsum 1OWG http://www.ebi.ac.uk/pdbsum/1OWG PDBsum 2HT0 http://www.ebi.ac.uk/pdbsum/2HT0 PDBsum 2IIE http://www.ebi.ac.uk/pdbsum/2IIE PDBsum 2IIF http://www.ebi.ac.uk/pdbsum/2IIF PRINTS PR01727 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01727 PROSITE PS00045 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00045 PSORT swissprot:IHFB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:IHFB_ECOLI PSORT-B swissprot:IHFB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:IHFB_ECOLI PSORT2 swissprot:IHFB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:IHFB_ECOLI Pfam PF00216 http://pfam.xfam.org/family/PF00216 Phobius swissprot:IHFB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:IHFB_ECOLI PhylomeDB P0A6Y1 http://phylomedb.org/?seqid=P0A6Y1 ProteinModelPortal P0A6Y1 http://www.proteinmodelportal.org/query/uniprot/P0A6Y1 PubMed 1531459 http://www.ncbi.nlm.nih.gov/pubmed/1531459 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17238924 http://www.ncbi.nlm.nih.gov/pubmed/17238924 PubMed 1917861 http://www.ncbi.nlm.nih.gov/pubmed/1917861 PubMed 3159903 http://www.ncbi.nlm.nih.gov/pubmed/3159903 PubMed 7499339 http://www.ncbi.nlm.nih.gov/pubmed/7499339 PubMed 7499340 http://www.ncbi.nlm.nih.gov/pubmed/7499340 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 8980235 http://www.ncbi.nlm.nih.gov/pubmed/8980235 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9868784 http://www.ncbi.nlm.nih.gov/pubmed/9868784 RefSeq NP_415432 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415432 RefSeq WP_000167336 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000167336 SMART SM00411 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00411 SMR P0A6Y1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6Y1 STRING 511145.b0912 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0912&targetmode=cogs STRING COG0776 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0776&targetmode=cogs SUPFAM SSF47729 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47729 TIGRFAMs TIGR00988 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00988 UniProtKB IHFB_ECOLI http://www.uniprot.org/uniprot/IHFB_ECOLI UniProtKB-AC P0A6Y1 http://www.uniprot.org/uniprot/P0A6Y1 charge swissprot:IHFB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:IHFB_ECOLI eggNOG COG0776 http://eggnogapi.embl.de/nog_data/html/tree/COG0776 eggNOG ENOG41080YA http://eggnogapi.embl.de/nog_data/html/tree/ENOG41080YA epestfind swissprot:IHFB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:IHFB_ECOLI garnier swissprot:IHFB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:IHFB_ECOLI helixturnhelix swissprot:IHFB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:IHFB_ECOLI hmoment swissprot:IHFB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:IHFB_ECOLI iep swissprot:IHFB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:IHFB_ECOLI inforesidue swissprot:IHFB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:IHFB_ECOLI octanol swissprot:IHFB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:IHFB_ECOLI pepcoil swissprot:IHFB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:IHFB_ECOLI pepdigest swissprot:IHFB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:IHFB_ECOLI pepinfo swissprot:IHFB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:IHFB_ECOLI pepnet swissprot:IHFB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:IHFB_ECOLI pepstats swissprot:IHFB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:IHFB_ECOLI pepwheel swissprot:IHFB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:IHFB_ECOLI pepwindow swissprot:IHFB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:IHFB_ECOLI sigcleave swissprot:IHFB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:IHFB_ECOLI ## Database ID URL or Descriptions # AltName Acetate--CoA ligase {ECO:0000255|HAMAP-Rule MF_01123} # AltName Acyl-activating enzyme {ECO:0000255|HAMAP-Rule MF_01123} # BIOPHYSICOCHEMICAL PROPERTIES ACSA_ECOLI Kinetic parameters KM=0.15 mM for ATP (at pH 8.5 and 37 degrees Celsius) {ECO 0000269|PubMed 21941}; KM=0.2 mM for CoA (at pH 8.5 and 37 degrees Celsius) {ECO 0000269|PubMed 21941}; KM=0.2 mM for acetate (at pH 8.5 and 37 degrees Celsius) {ECO 0000269|PubMed 21941}; Vmax=100 nmol/min/mg enzyme (at pH 8.5 and 37 degrees Celsius) {ECO 0000269|PubMed 21941}; pH dependence Optimum pH is 8.5. {ECO 0000269|PubMed 21941}; # BioGrid 4262675 10 # CATALYTIC ACTIVITY ACSA_ECOLI ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. {ECO 0000255|HAMAP-Rule MF_01123, ECO 0000269|PubMed 21941, ECO 0000269|PubMed 7751300}. # CDD cd05966 ACS # COFACTOR ACSA_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_01123, ECO 0000269|PubMed 21941}; # DISRUPTION PHENOTYPE Cells lacking this gene grow as well as wild-type cells at high concentrations (>25 mM) of acetate as the sole carbon source, but grow poorly on lower concentrations (<10 mM). {ECO:0000269|PubMed 7751300}. # EcoGene EG11448 acs # FUNCTION ACSA_ECOLI Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl- adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. # FUNCTION ACSA_ECOLI Enables the cell to use acetate during aerobic growth to generate energy via the TCA cycle, and biosynthetic compounds via the glyoxylate shunt. Acetylates CheY, the response regulator involved in flagellar movement and chemotaxis. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003987 acetate-CoA ligase activity; IDA:CACAO. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016208 AMP binding; IEA:InterPro. # GO_function GO:0033558 protein deacetylase activity; IDA:CACAO. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0050218 propionate-CoA ligase activity; IDA:EcoCyc. # GO_process GO:0006935 chemotaxis; IEA:UniProtKB-HAMAP. # GO_process GO:0018394 peptidyl-lysine acetylation; IDA:CACAO. # GO_process GO:0019427 acetyl-CoA biosynthetic process from acetate; IEA:UniProtKB-HAMAP. # GO_process GO:0034421 post-translational protein acetylation; IDA:CACAO. # GO_process GO:0045733 acetate catabolic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0040011 locomotion # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # HAMAP MF_01123 Ac_CoA_synth # INDUCTION By CRP and FNR, in response to rising cAMP levels, falling oxygen partial pressure and changes in carbon flux. May also be induced by acetate. {ECO:0000269|PubMed 10894724}. # IntAct P27550 7 # InterPro IPR000873 AMP-dep_Synth/Lig # InterPro IPR011904 Ac_CoA_lig # InterPro IPR020845 AMP-binding_CS # InterPro IPR025110 AMP-bd_C # InterPro IPR032387 ACAS_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01004 Lipid biosynthesis proteins # KEGG_Pathway ko00010 Glycolysis / Gluconeogenesis # KEGG_Pathway ko00620 Pyruvate metabolism # KEGG_Pathway ko00640 Propanoate metabolism # KEGG_Pathway ko00680 Methane metabolism # KEGG_Pathway ko00720 Carbon fixation pathways in prokaryotes # Organism ACSA_ECOLI Escherichia coli (strain K12) # PATRIC 32123687 VBIEscCol129921_4192 # PIR D65215 D65215 # PROSITE PS00455 AMP_BINDING # PTM ACSA_ECOLI Autoacetylated. Deacetylation by CobB activates the enzyme. # Pfam PF00501 AMP-binding # Pfam PF13193 AMP-binding_C # Pfam PF16177 ACAS_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Acetyl-coenzyme A synthetase {ECO:0000255|HAMAP-Rule MF_01123} # RefSeq NP_418493 NC_000913.3 # RefSeq WP_000078239 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA24715.1; Type=Frameshift; Positions=323; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ATP-dependent AMP-binding enzyme family. {ECO:0000255|HAMAP-Rule MF_01123}. # SUBUNIT Forms a 1 1 complex with CobB/NAD-dependent deacetylase. # TIGRFAMs TIGR02188 Ac_CoA_lig_AcsA # eggNOG COG0365 LUCA # eggNOG ENOG4108IQF Bacteria BLAST swissprot:ACSA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ACSA_ECOLI BioCyc ECOL316407:JW4030-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4030-MONOMER BioCyc EcoCyc:ACS-MONOMER http://biocyc.org/getid?id=EcoCyc:ACS-MONOMER BioCyc MetaCyc:ACS-MONOMER http://biocyc.org/getid?id=MetaCyc:ACS-MONOMER COG COG0365 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0365 DOI 10.1016/j.jmb.2004.01.060 http://dx.doi.org/10.1016/j.jmb.2004.01.060 DOI 10.1016/j.jmb.2004.07.020 http://dx.doi.org/10.1016/j.jmb.2004.07.020 DOI 10.1021/bi00156a033 http://dx.doi.org/10.1021/bi00156a033 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2001.02425.x http://dx.doi.org/10.1046/j.1365-2958.2001.02425.x DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1099/00221287-102-2-327 http://dx.doi.org/10.1099/00221287-102-2-327 DOI 10.1099/00221287-138-10-2101 http://dx.doi.org/10.1099/00221287-138-10-2101 DOI 10.1111/j.1365-2958.2010.07125.x http://dx.doi.org/10.1111/j.1365-2958.2010.07125.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.15.4173-4179.2000 http://dx.doi.org/10.1128/JB.182.15.4173-4179.2000 EC_number EC:6.2.1.1 {ECO:0000255|HAMAP-Rule:MF_01123} http://www.genome.jp/dbget-bin/www_bget?EC:6.2.1.1 {ECO:0000255|HAMAP-Rule:MF_01123} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M87509 http://www.ebi.ac.uk/ena/data/view/M87509 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 6.2.1.1 {ECO:0000255|HAMAP-Rule:MF_01123} http://enzyme.expasy.org/EC/6.2.1.1 {ECO:0000255|HAMAP-Rule:MF_01123} EchoBASE EB1417 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1417 EcoGene EG11448 http://www.ecogene.org/geneInfo.php?eg_id=EG11448 EnsemblBacteria AAC77039 http://www.ensemblgenomes.org/id/AAC77039 EnsemblBacteria AAC77039 http://www.ensemblgenomes.org/id/AAC77039 EnsemblBacteria BAE78071 http://www.ensemblgenomes.org/id/BAE78071 EnsemblBacteria BAE78071 http://www.ensemblgenomes.org/id/BAE78071 EnsemblBacteria BAE78071 http://www.ensemblgenomes.org/id/BAE78071 EnsemblBacteria b4069 http://www.ensemblgenomes.org/id/b4069 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003987 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003987 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016208 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016208 GO_function GO:0033558 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033558 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0050218 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050218 GO_process GO:0006935 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006935 GO_process GO:0018394 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018394 GO_process GO:0019427 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019427 GO_process GO:0034421 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034421 GO_process GO:0045733 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045733 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0040011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GeneID 948572 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948572 HAMAP MF_01123 http://hamap.expasy.org/unirule/MF_01123 HOGENOM HOG000229981 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000229981&db=HOGENOM6 InParanoid P27550 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P27550 IntAct P27550 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P27550* IntEnz 6.2.1.1 {ECO:0000255|HAMAP-Rule:MF_01123} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.2.1.1 {ECO:0000255|HAMAP-Rule:MF_01123} InterPro IPR000873 http://www.ebi.ac.uk/interpro/entry/IPR000873 InterPro IPR011904 http://www.ebi.ac.uk/interpro/entry/IPR011904 InterPro IPR020845 http://www.ebi.ac.uk/interpro/entry/IPR020845 InterPro IPR025110 http://www.ebi.ac.uk/interpro/entry/IPR025110 InterPro IPR032387 http://www.ebi.ac.uk/interpro/entry/IPR032387 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01004 http://www.genome.jp/dbget-bin/www_bget?ko01004 KEGG_Gene ecj:JW4030 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4030 KEGG_Gene eco:b4069 http://www.genome.jp/dbget-bin/www_bget?eco:b4069 KEGG_Orthology KO:K01895 http://www.genome.jp/dbget-bin/www_bget?KO:K01895 KEGG_Pathway ko00010 http://www.genome.jp/kegg-bin/show_pathway?ko00010 KEGG_Pathway ko00620 http://www.genome.jp/kegg-bin/show_pathway?ko00620 KEGG_Pathway ko00640 http://www.genome.jp/kegg-bin/show_pathway?ko00640 KEGG_Pathway ko00680 http://www.genome.jp/kegg-bin/show_pathway?ko00680 KEGG_Pathway ko00720 http://www.genome.jp/kegg-bin/show_pathway?ko00720 KEGG_Reaction rn:R00235 http://www.genome.jp/dbget-bin/www_bget?rn:R00235 KEGG_Reaction rn:R00236 http://www.genome.jp/dbget-bin/www_bget?rn:R00236 KEGG_Reaction rn:R00316 http://www.genome.jp/dbget-bin/www_bget?rn:R00316 KEGG_Reaction rn:R00926 http://www.genome.jp/dbget-bin/www_bget?rn:R00926 KEGG_Reaction rn:R01354 http://www.genome.jp/dbget-bin/www_bget?rn:R01354 OMA EGAPNWP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EGAPNWP PROSITE PS00455 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00455 PSORT swissprot:ACSA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ACSA_ECOLI PSORT-B swissprot:ACSA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ACSA_ECOLI PSORT2 swissprot:ACSA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ACSA_ECOLI Pfam PF00501 http://pfam.xfam.org/family/PF00501 Pfam PF13193 http://pfam.xfam.org/family/PF13193 Pfam PF16177 http://pfam.xfam.org/family/PF16177 Phobius swissprot:ACSA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ACSA_ECOLI PhylomeDB P27550 http://phylomedb.org/?seqid=P27550 ProteinModelPortal P27550 http://www.proteinmodelportal.org/query/uniprot/P27550 PubMed 10894724 http://www.ncbi.nlm.nih.gov/pubmed/10894724 PubMed 11359578 http://www.ncbi.nlm.nih.gov/pubmed/11359578 PubMed 1390767 http://www.ncbi.nlm.nih.gov/pubmed/1390767 PubMed 1479344 http://www.ncbi.nlm.nih.gov/pubmed/1479344 PubMed 15019790 http://www.ncbi.nlm.nih.gov/pubmed/15019790 PubMed 15327942 http://www.ncbi.nlm.nih.gov/pubmed/15327942 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20345663 http://www.ncbi.nlm.nih.gov/pubmed/20345663 PubMed 21941 http://www.ncbi.nlm.nih.gov/pubmed/21941 PubMed 7751300 http://www.ncbi.nlm.nih.gov/pubmed/7751300 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9473056 http://www.ncbi.nlm.nih.gov/pubmed/9473056 RefSeq NP_418493 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418493 RefSeq WP_000078239 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000078239 SMR P27550 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P27550 STRING 511145.b4069 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4069&targetmode=cogs STRING COG0365 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0365&targetmode=cogs TIGRFAMs TIGR02188 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02188 UniProtKB ACSA_ECOLI http://www.uniprot.org/uniprot/ACSA_ECOLI UniProtKB-AC P27550 http://www.uniprot.org/uniprot/P27550 charge swissprot:ACSA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ACSA_ECOLI eggNOG COG0365 http://eggnogapi.embl.de/nog_data/html/tree/COG0365 eggNOG ENOG4108IQF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108IQF epestfind swissprot:ACSA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ACSA_ECOLI garnier swissprot:ACSA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ACSA_ECOLI helixturnhelix swissprot:ACSA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ACSA_ECOLI hmoment swissprot:ACSA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ACSA_ECOLI iep swissprot:ACSA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ACSA_ECOLI inforesidue swissprot:ACSA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ACSA_ECOLI octanol swissprot:ACSA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ACSA_ECOLI pepcoil swissprot:ACSA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ACSA_ECOLI pepdigest swissprot:ACSA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ACSA_ECOLI pepinfo swissprot:ACSA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ACSA_ECOLI pepnet swissprot:ACSA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ACSA_ECOLI pepstats swissprot:ACSA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ACSA_ECOLI pepwheel swissprot:ACSA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ACSA_ECOLI pepwindow swissprot:ACSA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ACSA_ECOLI sigcleave swissprot:ACSA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ACSA_ECOLI ## Database ID URL or Descriptions # AltName AROP_ECOLI General aromatic amino acid permease # BioGrid 4259731 9 # EcoGene EG10084 aroP # FUNCTION AROP_ECOLI Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan). # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_function GO:0005302 L-tyrosine transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0009977 proton motive force dependent protein transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0015192 L-phenylalanine transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0015196 L-tryptophan transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0015297 antiporter activity; IBA:GO_Central. # GO_process GO:0015823 phenylalanine transport; IDA:EcoCyc. # GO_process GO:0015827 tryptophan transport; IDA:EcoCyc. # GO_process GO:0015828 tyrosine transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0008565 protein transporter activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # INDUCTION AROP_ECOLI Its activity is regulated by protein TyrR. # InterPro IPR002293 AA/rel_permease1 # InterPro IPR004840 Amoino_acid_permease_CS # InterPro IPR004841 AA-permease/SLC12A_dom # KEGG_Brite ko02000 Transporters # Organism AROP_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11785 PTHR11785 # PATRIC 32115325 VBIEscCol129921_0114 # PIR H64733 QRECAA # PIRSF PIRSF006060 AA_transporter # PROSITE PS00218 AMINO_ACID_PERMEASE_1 # Pfam PF00324 AA_permease # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AROP_ECOLI Aromatic amino acid transport protein AroP # RefSeq NP_414654 NC_000913.3 # SIMILARITY Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family. {ECO 0000305}. # SUBCELLULAR LOCATION AROP_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.3.1 the amino acid-polyamine-organocation (apc) family # eggNOG COG1113 LUCA # eggNOG ENOG4105C85 Bacteria BLAST swissprot:AROP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AROP_ECOLI BioCyc ECOL316407:JW0108-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0108-MONOMER BioCyc EcoCyc:AROP-MONOMER http://biocyc.org/getid?id=EcoCyc:AROP-MONOMER BioCyc MetaCyc:AROP-MONOMER http://biocyc.org/getid?id=MetaCyc:AROP-MONOMER COG COG1113 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1113 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/18.3.653 http://dx.doi.org/10.1093/nar/18.3.653 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U87285 http://www.ebi.ac.uk/ena/data/view/U87285 EMBL X17333 http://www.ebi.ac.uk/ena/data/view/X17333 EchoBASE EB0082 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0082 EcoGene EG10084 http://www.ecogene.org/geneInfo.php?eg_id=EG10084 EnsemblBacteria AAC73223 http://www.ensemblgenomes.org/id/AAC73223 EnsemblBacteria AAC73223 http://www.ensemblgenomes.org/id/AAC73223 EnsemblBacteria BAB96681 http://www.ensemblgenomes.org/id/BAB96681 EnsemblBacteria BAB96681 http://www.ensemblgenomes.org/id/BAB96681 EnsemblBacteria BAB96681 http://www.ensemblgenomes.org/id/BAB96681 EnsemblBacteria b0112 http://www.ensemblgenomes.org/id/b0112 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0005302 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005302 GO_function GO:0009977 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009977 GO_function GO:0015192 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015192 GO_function GO:0015196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015196 GO_function GO:0015297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015297 GO_process GO:0015823 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015823 GO_process GO:0015827 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015827 GO_process GO:0015828 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015828 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 946018 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946018 HOGENOM HOG000261849 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261849&db=HOGENOM6 InParanoid P15993 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P15993 InterPro IPR002293 http://www.ebi.ac.uk/interpro/entry/IPR002293 InterPro IPR004840 http://www.ebi.ac.uk/interpro/entry/IPR004840 InterPro IPR004841 http://www.ebi.ac.uk/interpro/entry/IPR004841 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0108 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0108 KEGG_Gene eco:b0112 http://www.genome.jp/dbget-bin/www_bget?eco:b0112 KEGG_Orthology KO:K11734 http://www.genome.jp/dbget-bin/www_bget?KO:K11734 OMA NYICLLF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NYICLLF PANTHER PTHR11785 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11785 PROSITE PS00218 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00218 PSORT swissprot:AROP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AROP_ECOLI PSORT-B swissprot:AROP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AROP_ECOLI PSORT2 swissprot:AROP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AROP_ECOLI Pfam PF00324 http://pfam.xfam.org/family/PF00324 Phobius swissprot:AROP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AROP_ECOLI PhylomeDB P15993 http://phylomedb.org/?seqid=P15993 ProteinModelPortal P15993 http://www.proteinmodelportal.org/query/uniprot/P15993 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2408019 http://www.ncbi.nlm.nih.gov/pubmed/2408019 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9150230 http://www.ncbi.nlm.nih.gov/pubmed/9150230 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414654 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414654 STRING 511145.b0112 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0112&targetmode=cogs STRING COG1113 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1113&targetmode=cogs TCDB 2.A.3.1 http://www.tcdb.org/search/result.php?tc=2.A.3.1 UniProtKB AROP_ECOLI http://www.uniprot.org/uniprot/AROP_ECOLI UniProtKB-AC P15993 http://www.uniprot.org/uniprot/P15993 charge swissprot:AROP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AROP_ECOLI eggNOG COG1113 http://eggnogapi.embl.de/nog_data/html/tree/COG1113 eggNOG ENOG4105C85 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C85 epestfind swissprot:AROP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AROP_ECOLI garnier swissprot:AROP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AROP_ECOLI helixturnhelix swissprot:AROP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AROP_ECOLI hmoment swissprot:AROP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AROP_ECOLI iep swissprot:AROP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AROP_ECOLI inforesidue swissprot:AROP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AROP_ECOLI octanol swissprot:AROP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AROP_ECOLI pepcoil swissprot:AROP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AROP_ECOLI pepdigest swissprot:AROP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AROP_ECOLI pepinfo swissprot:AROP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AROP_ECOLI pepnet swissprot:AROP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AROP_ECOLI pepstats swissprot:AROP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AROP_ECOLI pepwheel swissprot:AROP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AROP_ECOLI pepwindow swissprot:AROP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AROP_ECOLI sigcleave swissprot:AROP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AROP_ECOLI ## Database ID URL or Descriptions # BioGrid 4260960 6 # CATALYTIC ACTIVITY ALSA_ECOLI ATP + H(2)O + monosaccharide(Out) = ADP + phosphate + monosaccharide(In). # EcoGene EG11959 alsA # FUNCTION ALSA_ECOLI Part of the ABC transporter complex AlsBAC involved in D-allose import. Probably responsible for energy coupling to the transport system. {ECO 0000269|PubMed 9401019}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0015407 monosaccharide-transporting ATPase activity; IEA:UniProtKB-EC. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.300 -; 2. # IntAct P32721 5 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00217 D-Allose transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism ALSA_ECOLI Escherichia coli (strain K12) # PATRIC 32123729 VBIEscCol129921_4213 # PIR S56315 S56315 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2; 2 # Pfam PF00005 ABC_tran; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ALSA_ECOLI D-allose import ATP-binding protein AlsA # RefSeq NP_418511 NC_000913.3 # RefSeq WP_000235257 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. D-allose importer (TC 3.A.1.2.6) family. {ECO 0000305}. # SIMILARITY Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA; 2 # SUBCELLULAR LOCATION ALSA_ECOLI Cell inner membrane {ECO 0000250}; Peripheral membrane protein {ECO 0000250}. # SUBUNIT The complex is composed of two ATP-binding proteins (AlsA), two transmembrane proteins (AlsC) and a solute-binding protein (AlsB). {ECO 0000305}. # SUPFAM SSF52540 SSF52540; 2 # TCDB 3.A.1.2 the atp-binding cassette (abc) superfamily # eggNOG COG1129 LUCA # eggNOG ENOG4105C2J Bacteria BLAST swissprot:ALSA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ALSA_ECOLI BioCyc ECOL316407:JW4048-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4048-MONOMER BioCyc EcoCyc:YJCW-MONOMER http://biocyc.org/getid?id=EcoCyc:YJCW-MONOMER BioCyc MetaCyc:YJCW-MONOMER http://biocyc.org/getid?id=MetaCyc:YJCW-MONOMER COG COG1129 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1129 DIP DIP-9093N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9093N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.3.17 http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.17 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 3.6.3.17 http://enzyme.expasy.org/EC/3.6.3.17 EchoBASE EB1902 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1902 EcoGene EG11959 http://www.ecogene.org/geneInfo.php?eg_id=EG11959 EnsemblBacteria AAC77048 http://www.ensemblgenomes.org/id/AAC77048 EnsemblBacteria AAC77048 http://www.ensemblgenomes.org/id/AAC77048 EnsemblBacteria BAE78090 http://www.ensemblgenomes.org/id/BAE78090 EnsemblBacteria BAE78090 http://www.ensemblgenomes.org/id/BAE78090 EnsemblBacteria BAE78090 http://www.ensemblgenomes.org/id/BAE78090 EnsemblBacteria b4087 http://www.ensemblgenomes.org/id/b4087 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0015407 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015407 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948593 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948593 InParanoid P32721 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32721 IntAct P32721 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32721* IntEnz 3.6.3.17 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.17 InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW4048 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4048 KEGG_Gene eco:b4087 http://www.genome.jp/dbget-bin/www_bget?eco:b4087 KEGG_Orthology KO:K10551 http://www.genome.jp/dbget-bin/www_bget?KO:K10551 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA HSINQNI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HSINQNI PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:ALSA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ALSA_ECOLI PSORT-B swissprot:ALSA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ALSA_ECOLI PSORT2 swissprot:ALSA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ALSA_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Phobius swissprot:ALSA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ALSA_ECOLI PhylomeDB P32721 http://phylomedb.org/?seqid=P32721 ProteinModelPortal P32721 http://www.proteinmodelportal.org/query/uniprot/P32721 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9401019 http://www.ncbi.nlm.nih.gov/pubmed/9401019 RefSeq NP_418511 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418511 RefSeq WP_000235257 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000235257 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 STRING 511145.b4087 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4087&targetmode=cogs STRING COG1129 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1129&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.2 http://www.tcdb.org/search/result.php?tc=3.A.1.2 UniProtKB ALSA_ECOLI http://www.uniprot.org/uniprot/ALSA_ECOLI UniProtKB-AC P32721 http://www.uniprot.org/uniprot/P32721 charge swissprot:ALSA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ALSA_ECOLI eggNOG COG1129 http://eggnogapi.embl.de/nog_data/html/tree/COG1129 eggNOG ENOG4105C2J http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C2J epestfind swissprot:ALSA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ALSA_ECOLI garnier swissprot:ALSA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ALSA_ECOLI helixturnhelix swissprot:ALSA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ALSA_ECOLI hmoment swissprot:ALSA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ALSA_ECOLI iep swissprot:ALSA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ALSA_ECOLI inforesidue swissprot:ALSA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ALSA_ECOLI octanol swissprot:ALSA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ALSA_ECOLI pepcoil swissprot:ALSA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ALSA_ECOLI pepdigest swissprot:ALSA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ALSA_ECOLI pepinfo swissprot:ALSA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ALSA_ECOLI pepnet swissprot:ALSA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ALSA_ECOLI pepstats swissprot:ALSA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ALSA_ECOLI pepwheel swissprot:ALSA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ALSA_ECOLI pepwindow swissprot:ALSA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ALSA_ECOLI sigcleave swissprot:ALSA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ALSA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261495 10 # EcoGene EG11815 torC # FUNCTION TORC_ECOLI Part of the anaerobic respiratory chain of trimethylamine-N-oxide reductase TorA. Acts by transferring electrons from the membranous menaquinones to TorA. This transfer probably involves an electron transfer pathway from menaquinones to the N-terminal domain of TorC, then from the N-terminus to the C-terminus, and finally to TorA. TorC apocytochrome negatively autoregulates the torCAD operon probably by inhibiting the TorS kinase activity. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0009276 Gram-negative-bacterium-type cell wall; IEA:InterPro. # GO_component GO:0016021 integral component of membrane; IDA:EcoCyc. # GO_component GO:1990204 oxidoreductase complex; IDA:EcoCyc. # GO_function GO:0005506 iron ion binding; IEA:InterPro. # GO_function GO:0009055 electron carrier activity; IDA:EcoCyc. # GO_function GO:0020037 heme binding; IDA:EcoCyc. # GO_process GO:0009060 aerobic respiration; IEP:EcoCyc. # GO_process GO:0009061 anaerobic respiration; IEP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005618 cell wall # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # INTERACTION TORC_ECOLI P33225 torA; NbExp=3; IntAct=EBI-553710, EBI-557008; # IntAct P33226 2 # InterPro IPR005126 NapC/NirT_cyt_c_N # InterPro IPR009154 Membr-bd_4haem_cyt_TorC # InterPro IPR011031 Multihaem_cyt # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02020 Two-component system # Organism TORC_ECOLI Escherichia coli (strain K12) # PATRIC 32117217 VBIEscCol129921_1032 # PIR B64841 S34221 # PIRSF PIRSF000014 4_hem_cytch_TorC # PROSITE PS51008 MULTIHEME_CYTC # PTM TORC_ECOLI Binds 5 heme groups per subunit. {ECO 0000250}. # Pfam PF03264 Cytochrom_NNT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TORC_ECOLI Cytochrome c-type protein TorC # RefSeq NP_415516 NC_000913.3 # RefSeq WP_001230242 NZ_LN832404.1 # SIMILARITY Belongs to the TorC/TorY family. {ECO 0000305}. # SUBCELLULAR LOCATION TORC_ECOLI Cell inner membrane; Single-pass type II membrane protein. # SUBUNIT TORC_ECOLI The N-terminal domain interacts with TorA. The immature C-terminal domain can bind to the N-terminal detector region of TorS. # SUPFAM SSF48695 SSF48695 # TCDB 5.A.3.4 the prokaryotic molybdopterin-containing oxidoreductase (pmo) family # TIGRFAMs TIGR02162 torC # eggNOG COG3005 LUCA # eggNOG ENOG4105CUW Bacteria BLAST swissprot:TORC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TORC_ECOLI BioCyc ECOL316407:JW0981-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0981-MONOMER BioCyc EcoCyc:EG11815-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11815-MONOMER BioCyc MetaCyc:EG11815-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11815-MONOMER COG COG3005 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3005 DIP DIP-11014N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11014N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1999.01468.x http://dx.doi.org/10.1046/j.1365-2958.1999.01468.x DOI 10.1073/pnas.211330598 http://dx.doi.org/10.1073/pnas.211330598 DOI 10.1074/jbc.M008875200 http://dx.doi.org/10.1074/jbc.M008875200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1994.tb00393.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb00393.x DOI 10.1111/j.1574-6968.1994.tb06872.x http://dx.doi.org/10.1111/j.1574-6968.1994.tb06872.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X73888 http://www.ebi.ac.uk/ena/data/view/X73888 EchoBASE EB1762 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1762 EcoGene EG11815 http://www.ecogene.org/geneInfo.php?eg_id=EG11815 EnsemblBacteria AAC74081 http://www.ensemblgenomes.org/id/AAC74081 EnsemblBacteria AAC74081 http://www.ensemblgenomes.org/id/AAC74081 EnsemblBacteria BAA36138 http://www.ensemblgenomes.org/id/BAA36138 EnsemblBacteria BAA36138 http://www.ensemblgenomes.org/id/BAA36138 EnsemblBacteria BAA36138 http://www.ensemblgenomes.org/id/BAA36138 EnsemblBacteria b0996 http://www.ensemblgenomes.org/id/b0996 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0009276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009276 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:1990204 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990204 GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0020037 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0020037 GO_process GO:0009060 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009060 GO_process GO:0009061 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009061 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005618 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GeneID 946252 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946252 HOGENOM HOG000284378 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000284378&db=HOGENOM6 IntAct P33226 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33226* InterPro IPR005126 http://www.ebi.ac.uk/interpro/entry/IPR005126 InterPro IPR009154 http://www.ebi.ac.uk/interpro/entry/IPR009154 InterPro IPR011031 http://www.ebi.ac.uk/interpro/entry/IPR011031 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0981 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0981 KEGG_Gene eco:b0996 http://www.genome.jp/dbget-bin/www_bget?eco:b0996 KEGG_Orthology KO:K03532 http://www.genome.jp/dbget-bin/www_bget?KO:K03532 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 MINT MINT-1285841 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1285841 OMA MISRIWK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MISRIWK PROSITE PS51008 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51008 PSORT swissprot:TORC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TORC_ECOLI PSORT-B swissprot:TORC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TORC_ECOLI PSORT2 swissprot:TORC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TORC_ECOLI Pfam PF03264 http://pfam.xfam.org/family/PF03264 Phobius swissprot:TORC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TORC_ECOLI ProteinModelPortal P33226 http://www.proteinmodelportal.org/query/uniprot/P33226 PubMed 10411745 http://www.ncbi.nlm.nih.gov/pubmed/10411745 PubMed 11056172 http://www.ncbi.nlm.nih.gov/pubmed/11056172 PubMed 11562502 http://www.ncbi.nlm.nih.gov/pubmed/11562502 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8022286 http://www.ncbi.nlm.nih.gov/pubmed/8022286 PubMed 8039676 http://www.ncbi.nlm.nih.gov/pubmed/8039676 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415516 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415516 RefSeq WP_001230242 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001230242 STRING 511145.b0996 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0996&targetmode=cogs STRING COG3005 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3005&targetmode=cogs SUPFAM SSF48695 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48695 TCDB 5.A.3.4 http://www.tcdb.org/search/result.php?tc=5.A.3.4 TIGRFAMs TIGR02162 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02162 UniProtKB TORC_ECOLI http://www.uniprot.org/uniprot/TORC_ECOLI UniProtKB-AC P33226 http://www.uniprot.org/uniprot/P33226 charge swissprot:TORC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TORC_ECOLI eggNOG COG3005 http://eggnogapi.embl.de/nog_data/html/tree/COG3005 eggNOG ENOG4105CUW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CUW epestfind swissprot:TORC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TORC_ECOLI garnier swissprot:TORC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TORC_ECOLI helixturnhelix swissprot:TORC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TORC_ECOLI hmoment swissprot:TORC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TORC_ECOLI iep swissprot:TORC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TORC_ECOLI inforesidue swissprot:TORC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TORC_ECOLI octanol swissprot:TORC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TORC_ECOLI pepcoil swissprot:TORC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TORC_ECOLI pepdigest swissprot:TORC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TORC_ECOLI pepinfo swissprot:TORC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TORC_ECOLI pepnet swissprot:TORC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TORC_ECOLI pepstats swissprot:TORC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TORC_ECOLI pepwheel swissprot:TORC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TORC_ECOLI pepwindow swissprot:TORC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TORC_ECOLI sigcleave swissprot:TORC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TORC_ECOLI ## Database ID URL or Descriptions # AltName HSCA_ECOLI Hsc66 # BioGrid 4262906 73 # EcoGene EG12130 hscA # FUNCTION HSCA_ECOLI Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:1990230 iron-sulfur cluster transfer complex; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IDA:EcoCyc. # GO_function GO:0016887 ATPase activity; IDA:EcoCyc. # GO_function GO:0043531 ADP binding; IDA:EcoCyc. # GO_process GO:0006457 protein folding; IEA:UniProtKB-HAMAP. # GO_process GO:0016226 iron-sulfur cluster assembly; IEA:InterPro. # GO_process GO:0070417 cellular response to cold; IEP:EcoCyc. # GO_process GO:0097428 protein maturation by iron-sulfur cluster transfer; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006457 protein folding # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0051186 cofactor metabolic process # GOslim_process GO:0051604 protein maturation # Gene3D 1.20.1270.10 -; 1. # Gene3D 2.60.34.10 -; 1. # HAMAP MF_00679 HscA # INDUCTION By cold shock. {ECO:0000269|PubMed 7665466}. # IntAct P0A6Z1 28 # InterPro IPR010236 ISC_FeS_clus_asmbl_HscA # InterPro IPR013126 Hsp_70_fam # InterPro IPR018181 Heat_shock_70_CS # InterPro IPR029047 HSP70_peptide-bd # InterPro IPR029048 HSP70_C # KEGG_Brite ko02000 Transporters # KEGG_Brite ko03110 Chaperones and folding catalysts # Organism HSCA_ECOLI Escherichia coli (strain K12) # PATRIC 32120447 VBIEscCol129921_2626 # PDB 1U00 X-ray; 1.95 A; A=389-615 # PIR E65029 E65029 # PRINTS PR00301 HEATSHOCK70 # PROSITE PS00297 HSP70_1 # PROSITE PS00329 HSP70_2 # PROSITE PS01036 HSP70_3 # Pfam PF00012 HSP70 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HSCA_ECOLI Chaperone protein HscA # RefSeq NP_417021 NC_000913.3 # RefSeq WP_001196613 NZ_LN832404.1 # SIMILARITY Belongs to the heat shock protein 70 family. {ECO 0000305}. # SUPFAM SSF100920 SSF100920 # SUPFAM SSF100934 SSF100934 # TIGRFAMs TIGR01991 HscA # eggNOG COG0443 LUCA # eggNOG ENOG4105C9I Bacteria BLAST swissprot:HSCA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HSCA_ECOLI BioCyc ECOL316407:JW2510-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2510-MONOMER BioCyc EcoCyc:EG12130-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12130-MONOMER BioCyc MetaCyc:EG12130-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12130-MONOMER COG COG0443 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0443 DIP DIP-47348N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47348N DOI 10.1002/pro.5560060511 http://dx.doi.org/10.1002/pro.5560060511 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.130201997 http://dx.doi.org/10.1073/pnas.130201997 DOI 10.1073/pnas.91.6.2066 http://dx.doi.org/10.1073/pnas.91.6.2066 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U01827 http://www.ebi.ac.uk/ena/data/view/U01827 EMBL U05338 http://www.ebi.ac.uk/ena/data/view/U05338 EchoBASE EB2051 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2051 EcoGene EG12130 http://www.ecogene.org/geneInfo.php?eg_id=EG12130 EnsemblBacteria AAC75579 http://www.ensemblgenomes.org/id/AAC75579 EnsemblBacteria AAC75579 http://www.ensemblgenomes.org/id/AAC75579 EnsemblBacteria BAA16420 http://www.ensemblgenomes.org/id/BAA16420 EnsemblBacteria BAA16420 http://www.ensemblgenomes.org/id/BAA16420 EnsemblBacteria BAA16420 http://www.ensemblgenomes.org/id/BAA16420 EnsemblBacteria b2526 http://www.ensemblgenomes.org/id/b2526 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:1990230 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990230 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_function GO:0043531 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043531 GO_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GO_process GO:0016226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016226 GO_process GO:0070417 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070417 GO_process GO:0097428 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097428 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GOslim_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 Gene3D 1.20.1270.10 http://www.cathdb.info/version/latest/superfamily/1.20.1270.10 Gene3D 2.60.34.10 http://www.cathdb.info/version/latest/superfamily/2.60.34.10 GeneID 944885 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944885 HAMAP MF_00679 http://hamap.expasy.org/unirule/MF_00679 HOGENOM HOG000228136 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000228136&db=HOGENOM6 InParanoid P0A6Z1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6Z1 IntAct P0A6Z1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6Z1* InterPro IPR010236 http://www.ebi.ac.uk/interpro/entry/IPR010236 InterPro IPR013126 http://www.ebi.ac.uk/interpro/entry/IPR013126 InterPro IPR018181 http://www.ebi.ac.uk/interpro/entry/IPR018181 InterPro IPR029047 http://www.ebi.ac.uk/interpro/entry/IPR029047 InterPro IPR029048 http://www.ebi.ac.uk/interpro/entry/IPR029048 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW2510 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2510 KEGG_Gene eco:b2526 http://www.genome.jp/dbget-bin/www_bget?eco:b2526 KEGG_Orthology KO:K04044 http://www.genome.jp/dbget-bin/www_bget?KO:K04044 OMA LRGIPAM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LRGIPAM PDB 1U00 http://www.ebi.ac.uk/pdbe-srv/view/entry/1U00 PDBsum 1U00 http://www.ebi.ac.uk/pdbsum/1U00 PRINTS PR00301 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00301 PROSITE PS00297 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00297 PROSITE PS00329 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00329 PROSITE PS01036 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01036 PSORT swissprot:HSCA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HSCA_ECOLI PSORT-B swissprot:HSCA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HSCA_ECOLI PSORT2 swissprot:HSCA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HSCA_ECOLI Pfam PF00012 http://pfam.xfam.org/family/PF00012 Phobius swissprot:HSCA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HSCA_ECOLI PhylomeDB P0A6Z1 http://phylomedb.org/?seqid=P0A6Z1 ProteinModelPortal P0A6Z1 http://www.proteinmodelportal.org/query/uniprot/P0A6Z1 PubMed 10869428 http://www.ncbi.nlm.nih.gov/pubmed/10869428 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7665466 http://www.ncbi.nlm.nih.gov/pubmed/7665466 PubMed 8134349 http://www.ncbi.nlm.nih.gov/pubmed/8134349 PubMed 8300516 http://www.ncbi.nlm.nih.gov/pubmed/8300516 PubMed 9144776 http://www.ncbi.nlm.nih.gov/pubmed/9144776 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417021 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417021 RefSeq WP_001196613 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001196613 SMR P0A6Z1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6Z1 STRING 511145.b2526 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2526&targetmode=cogs STRING COG0443 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0443&targetmode=cogs SUPFAM SSF100920 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF100920 SUPFAM SSF100934 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF100934 TIGRFAMs TIGR01991 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01991 UniProtKB HSCA_ECOLI http://www.uniprot.org/uniprot/HSCA_ECOLI UniProtKB-AC P0A6Z1 http://www.uniprot.org/uniprot/P0A6Z1 charge swissprot:HSCA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HSCA_ECOLI eggNOG COG0443 http://eggnogapi.embl.de/nog_data/html/tree/COG0443 eggNOG ENOG4105C9I http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C9I epestfind swissprot:HSCA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HSCA_ECOLI garnier swissprot:HSCA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HSCA_ECOLI helixturnhelix swissprot:HSCA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HSCA_ECOLI hmoment swissprot:HSCA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HSCA_ECOLI iep swissprot:HSCA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HSCA_ECOLI inforesidue swissprot:HSCA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HSCA_ECOLI octanol swissprot:HSCA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HSCA_ECOLI pepcoil swissprot:HSCA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HSCA_ECOLI pepdigest swissprot:HSCA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HSCA_ECOLI pepinfo swissprot:HSCA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HSCA_ECOLI pepnet swissprot:HSCA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HSCA_ECOLI pepstats swissprot:HSCA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HSCA_ECOLI pepwheel swissprot:HSCA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HSCA_ECOLI pepwindow swissprot:HSCA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HSCA_ECOLI sigcleave swissprot:HSCA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HSCA_ECOLI ## Database ID URL or Descriptions # AltName MNGR_ECOLI Fatty acyl-responsive regulator # AltName MNGR_ECOLI Protein P30 # BioGrid 4261225 5 # CAUTION Originally proposed to be involved in the regulation of the acid citric cycle in response to fatty acids. This was based on in vitro experiments showing that MngR was released from its DNA-binding sites by high concentration sof fatty acids and acyl- CoAs. These results could be explained by the fact that these high-concentrations of fatty acids could have denatured the MngR protein. {ECO 0000305}. # CDD cd07377 WHTH_GntR # DISRUPTION PHENOTYPE In cells lacking this gene the expression of mngA and mngB increases by 9-fold and 23-fold, respectively. {ECO:0000269|PubMed 14645248}. # EcoGene EG11109 mngR # FUNCTION MNGR_ECOLI Represses mngA and mngB. Regulates its own expression. {ECO 0000269|PubMed 14645248, ECO 0000269|PubMed 7805834}. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0009408 response to heat; IMP:EcoCyc. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # Gene3D 3.40.1410.10 -; 1. # INDUCTION MNGR_ECOLI Induced by mannosyl-D-glycerate. # IntAct P13669 4 # InterPro IPR000524 Tscrpt_reg_HTH_GntR # InterPro IPR011663 UTRA # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR028978 Chorismate_lyase_/UTRA_dom # KEGG_Brite ko03000 Transcription factors # Organism MNGR_ECOLI Escherichia coli (strain K12) # PATRIC 32116655 VBIEscCol129921_0760 # PIR S04645 S04645 # PRINTS PR00035 HTHGNTR # PROSITE PS50949 HTH_GNTR # Pfam PF00392 GntR # Pfam PF07702 UTRA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MNGR_ECOLI Mannosyl-D-glycerate transport/metabolism system repressor MngR # RefSeq NP_415258 NC_000913.3 # RefSeq WP_000509902 NZ_LN832404.1 # SIMILARITY Contains 1 HTH gntR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00307}. # SMART SM00345 HTH_GNTR # SMART SM00866 UTRA # SUPFAM SSF46785 SSF46785 # SUPFAM SSF64288 SSF64288 # eggNOG COG2188 LUCA # eggNOG ENOG4105FDP Bacteria BLAST swissprot:MNGR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MNGR_ECOLI BioCyc ECOL316407:JW0719-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0719-MONOMER BioCyc EcoCyc:PD01103 http://biocyc.org/getid?id=EcoCyc:PD01103 COG COG2188 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2188 DIP DIP-9565N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9565N DOI 10.1016/0014-5793(94)01264-4 http://dx.doi.org/10.1016/0014-5793(94)01264-4 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2600737 http://dx.doi.org/10.1042/bj2600737 DOI 10.1074/jbc.M310980200 http://dx.doi.org/10.1074/jbc.M310980200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1271/bbb.60.309 http://dx.doi.org/10.1271/bbb.60.309 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D64014 http://www.ebi.ac.uk/ena/data/view/D64014 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X15790 http://www.ebi.ac.uk/ena/data/view/X15790 EchoBASE EB1100 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1100 EcoGene EG11109 http://www.ecogene.org/geneInfo.php?eg_id=EG11109 EnsemblBacteria AAC73824 http://www.ensemblgenomes.org/id/AAC73824 EnsemblBacteria AAC73824 http://www.ensemblgenomes.org/id/AAC73824 EnsemblBacteria BAA35396 http://www.ensemblgenomes.org/id/BAA35396 EnsemblBacteria BAA35396 http://www.ensemblgenomes.org/id/BAA35396 EnsemblBacteria BAA35396 http://www.ensemblgenomes.org/id/BAA35396 EnsemblBacteria b0730 http://www.ensemblgenomes.org/id/b0730 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 3.40.1410.10 http://www.cathdb.info/version/latest/superfamily/3.40.1410.10 GeneID 945371 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945371 HOGENOM HOG000228717 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000228717&db=HOGENOM6 InParanoid P13669 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P13669 IntAct P13669 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P13669* InterPro IPR000524 http://www.ebi.ac.uk/interpro/entry/IPR000524 InterPro IPR011663 http://www.ebi.ac.uk/interpro/entry/IPR011663 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR028978 http://www.ebi.ac.uk/interpro/entry/IPR028978 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW0719 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0719 KEGG_Gene eco:b0730 http://www.genome.jp/dbget-bin/www_bget?eco:b0730 KEGG_Orthology KO:K11922 http://www.genome.jp/dbget-bin/www_bget?KO:K11922 OMA YRISRAN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YRISRAN PRINTS PR00035 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00035 PROSITE PS50949 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50949 PSORT swissprot:MNGR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MNGR_ECOLI PSORT-B swissprot:MNGR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MNGR_ECOLI PSORT2 swissprot:MNGR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MNGR_ECOLI Pfam PF00392 http://pfam.xfam.org/family/PF00392 Pfam PF07702 http://pfam.xfam.org/family/PF07702 Phobius swissprot:MNGR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MNGR_ECOLI PhylomeDB P13669 http://phylomedb.org/?seqid=P13669 ProteinModelPortal P13669 http://www.proteinmodelportal.org/query/uniprot/P13669 PubMed 14645248 http://www.ncbi.nlm.nih.gov/pubmed/14645248 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2548486 http://www.ncbi.nlm.nih.gov/pubmed/2548486 PubMed 7805834 http://www.ncbi.nlm.nih.gov/pubmed/7805834 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9063979 http://www.ncbi.nlm.nih.gov/pubmed/9063979 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415258 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415258 RefSeq WP_000509902 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000509902 SMART SM00345 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00345 SMART SM00866 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00866 SMR P13669 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P13669 STRING 511145.b0730 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0730&targetmode=cogs STRING COG2188 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2188&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SUPFAM SSF64288 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF64288 UniProtKB MNGR_ECOLI http://www.uniprot.org/uniprot/MNGR_ECOLI UniProtKB-AC P13669 http://www.uniprot.org/uniprot/P13669 charge swissprot:MNGR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MNGR_ECOLI eggNOG COG2188 http://eggnogapi.embl.de/nog_data/html/tree/COG2188 eggNOG ENOG4105FDP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FDP epestfind swissprot:MNGR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MNGR_ECOLI garnier swissprot:MNGR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MNGR_ECOLI helixturnhelix swissprot:MNGR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MNGR_ECOLI hmoment swissprot:MNGR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MNGR_ECOLI iep swissprot:MNGR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MNGR_ECOLI inforesidue swissprot:MNGR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MNGR_ECOLI octanol swissprot:MNGR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MNGR_ECOLI pepcoil swissprot:MNGR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MNGR_ECOLI pepdigest swissprot:MNGR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MNGR_ECOLI pepinfo swissprot:MNGR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MNGR_ECOLI pepnet swissprot:MNGR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MNGR_ECOLI pepstats swissprot:MNGR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MNGR_ECOLI pepwheel swissprot:MNGR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MNGR_ECOLI pepwindow swissprot:MNGR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MNGR_ECOLI sigcleave swissprot:MNGR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MNGR_ECOLI ## Database ID URL or Descriptions # BioGrid 4260105 645 # CATALYTIC ACTIVITY ALR2_ECOLI L-alanine = D-alanine. # COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI 597326; Evidence={ECO:0000250}; # EcoGene EG11408 dadX # FUNCTION ALR2_ECOLI Isomerizes L-alanine to D-alanine which is then oxidized to pyruvate by DadA. {ECO 0000250}. # GO_function GO:0008784 alanine racemase activity; IDA:EcoCyc. # GO_function GO:0030170 pyridoxal phosphate binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006522 alanine metabolic process; IEA:UniProtKB-HAMAP. # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # Gene3D 2.40.37.10 -; 1. # Gene3D 3.20.20.10 -; 1. # HAMAP MF_01201 Ala_racemase # INDUCTION By alanine. {ECO:0000269|PubMed 7906689}. # IntAct P29012 2 # InterPro IPR000821 Ala_racemase # InterPro IPR001608 Ala_racemase_N # InterPro IPR009006 Ala_racemase/Decarboxylase_C # InterPro IPR011079 Ala_racemase_C # InterPro IPR020622 Ala_racemase_pyridoxalP-BS # InterPro IPR029066 PLP-binding_barrel # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00473 D-Alanine metabolism # Organism ALR2_ECOLI Escherichia coli (strain K12) # PATRIC 32117626 VBIEscCol129921_1235 # PIR C64865 C53383 # PRINTS PR00992 ALARACEMASE # PROSITE PS00395 ALANINE_RACEMASE # Pfam PF00842 Ala_racemase_C # Pfam PF01168 Ala_racemase_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ALR2_ECOLI Alanine racemase, catabolic # RefSeq NP_415708 NC_000913.3 # RefSeq WP_000197881 NZ_LN832404.1 # SIMILARITY Belongs to the alanine racemase family. {ECO 0000305}. # SMART SM01005 Ala_racemase_C # SUPFAM SSF50621 SSF50621 # SUPFAM SSF51419 SSF51419 # TIGRFAMs TIGR00492 alr # eggNOG COG0787 LUCA # eggNOG ENOG4105CJ4 Bacteria BLAST swissprot:ALR2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ALR2_ECOLI BioCyc ECOL316407:JW1179-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1179-MONOMER BioCyc EcoCyc:ALARACECAT-MONOMER http://biocyc.org/getid?id=EcoCyc:ALARACECAT-MONOMER BioCyc MetaCyc:ALARACECAT-MONOMER http://biocyc.org/getid?id=MetaCyc:ALARACECAT-MONOMER COG COG0787 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0787 DIP DIP-9395N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9395N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.1.1.1 http://www.genome.jp/dbget-bin/www_bget?EC:5.1.1.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L02948 http://www.ebi.ac.uk/ena/data/view/L02948 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 5.1.1.1 http://enzyme.expasy.org/EC/5.1.1.1 EchoBASE EB1380 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1380 EcoGene EG11408 http://www.ecogene.org/geneInfo.php?eg_id=EG11408 EnsemblBacteria AAC74274 http://www.ensemblgenomes.org/id/AAC74274 EnsemblBacteria AAC74274 http://www.ensemblgenomes.org/id/AAC74274 EnsemblBacteria BAA36045 http://www.ensemblgenomes.org/id/BAA36045 EnsemblBacteria BAA36045 http://www.ensemblgenomes.org/id/BAA36045 EnsemblBacteria BAA36045 http://www.ensemblgenomes.org/id/BAA36045 EnsemblBacteria b1190 http://www.ensemblgenomes.org/id/b1190 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008784 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008784 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_process GO:0006522 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006522 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 Gene3D 2.40.37.10 http://www.cathdb.info/version/latest/superfamily/2.40.37.10 Gene3D 3.20.20.10 http://www.cathdb.info/version/latest/superfamily/3.20.20.10 GeneID 945754 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945754 HAMAP MF_01201 http://hamap.expasy.org/unirule/MF_01201 HOGENOM HOG000031446 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000031446&db=HOGENOM6 InParanoid P29012 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P29012 IntAct P29012 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P29012* IntEnz 5.1.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.1.1.1 InterPro IPR000821 http://www.ebi.ac.uk/interpro/entry/IPR000821 InterPro IPR001608 http://www.ebi.ac.uk/interpro/entry/IPR001608 InterPro IPR009006 http://www.ebi.ac.uk/interpro/entry/IPR009006 InterPro IPR011079 http://www.ebi.ac.uk/interpro/entry/IPR011079 InterPro IPR020622 http://www.ebi.ac.uk/interpro/entry/IPR020622 InterPro IPR029066 http://www.ebi.ac.uk/interpro/entry/IPR029066 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1179 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1179 KEGG_Gene eco:b1190 http://www.genome.jp/dbget-bin/www_bget?eco:b1190 KEGG_Orthology KO:K01775 http://www.genome.jp/dbget-bin/www_bget?KO:K01775 KEGG_Pathway ko00473 http://www.genome.jp/kegg-bin/show_pathway?ko00473 KEGG_Reaction rn:R00401 http://www.genome.jp/dbget-bin/www_bget?rn:R00401 OMA HMTHFSD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HMTHFSD PRINTS PR00992 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00992 PROSITE PS00395 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00395 PSORT swissprot:ALR2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ALR2_ECOLI PSORT-B swissprot:ALR2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ALR2_ECOLI PSORT2 swissprot:ALR2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ALR2_ECOLI Pfam PF00842 http://pfam.xfam.org/family/PF00842 Pfam PF01168 http://pfam.xfam.org/family/PF01168 Phobius swissprot:ALR2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ALR2_ECOLI PhylomeDB P29012 http://phylomedb.org/?seqid=P29012 ProteinModelPortal P29012 http://www.proteinmodelportal.org/query/uniprot/P29012 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7906689 http://www.ncbi.nlm.nih.gov/pubmed/7906689 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415708 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415708 RefSeq WP_000197881 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000197881 SMART SM01005 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01005 SMR P29012 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P29012 STRING 511145.b1190 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1190&targetmode=cogs STRING COG0787 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0787&targetmode=cogs SUPFAM SSF50621 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50621 SUPFAM SSF51419 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51419 TIGRFAMs TIGR00492 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00492 UniProtKB ALR2_ECOLI http://www.uniprot.org/uniprot/ALR2_ECOLI UniProtKB-AC P29012 http://www.uniprot.org/uniprot/P29012 charge swissprot:ALR2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ALR2_ECOLI eggNOG COG0787 http://eggnogapi.embl.de/nog_data/html/tree/COG0787 eggNOG ENOG4105CJ4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CJ4 epestfind swissprot:ALR2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ALR2_ECOLI garnier swissprot:ALR2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ALR2_ECOLI helixturnhelix swissprot:ALR2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ALR2_ECOLI hmoment swissprot:ALR2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ALR2_ECOLI iep swissprot:ALR2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ALR2_ECOLI inforesidue swissprot:ALR2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ALR2_ECOLI octanol swissprot:ALR2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ALR2_ECOLI pepcoil swissprot:ALR2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ALR2_ECOLI pepdigest swissprot:ALR2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ALR2_ECOLI pepinfo swissprot:ALR2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ALR2_ECOLI pepnet swissprot:ALR2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ALR2_ECOLI pepstats swissprot:ALR2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ALR2_ECOLI pepwheel swissprot:ALR2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ALR2_ECOLI pepwindow swissprot:ALR2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ALR2_ECOLI sigcleave swissprot:ALR2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ALR2_ECOLI ## Database ID URL or Descriptions # AltName ATOB_ECOLI Acetoacetyl-CoA thiolase # BioGrid 4263266 7 # CATALYTIC ACTIVITY 2 acetyl-CoA = CoA + acetoacetyl-CoA. {ECO:0000255|PROSITE-ProRule PRU10020}. # EcoGene EG11672 atoB # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003985 acetyl-CoA C-acetyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0003988 acetyl-CoA C-acyltransferase activity; IBA:GO_Central. # GO_process GO:0006635 fatty acid beta-oxidation; IBA:GO_Central. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.47.10 -; 4. # IntAct P76461 3 # InterPro IPR002155 Thiolase # InterPro IPR016039 Thiolase-like # InterPro IPR020610 Thiolase_AS # InterPro IPR020613 Thiolase_CS # InterPro IPR020615 Thiolase_acyl_enz_int_AS # InterPro IPR020616 Thiolase_N # InterPro IPR020617 Thiolase_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00071 Fatty acid metabolism # KEGG_Pathway ko00072 Synthesis and degradation of ketone bodies # KEGG_Pathway ko00280 Valine, leucine and isoleucine degradation # KEGG_Pathway ko00310 Lysine degradation # KEGG_Pathway ko00362 Benzoate degradation # KEGG_Pathway ko00380 Tryptophan metabolism # KEGG_Pathway ko00620 Pyruvate metabolism # KEGG_Pathway ko00630 Glyoxylate and dicarboxylate metabolism # KEGG_Pathway ko00640 Propanoate metabolism # KEGG_Pathway ko00650 Butanoate metabolism # KEGG_Pathway ko00720 Carbon fixation pathways in prokaryotes # KEGG_Pathway ko00900 Terpenoid backbone biosynthesis # KEGG_Pathway ko02020 Two-component system # Organism ATOB_ECOLI Escherichia coli (strain K12) # PATHWAY Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA step 1/3. # PATRIC 32119807 VBIEscCol129921_2313 # PDB 4WYS X-ray; 2.10 A; A/B/C/D=1-393 # PDB 5F0V X-ray; 1.80 A; A/B/C/D=1-393 # PDB 5F38 X-ray; 1.90 A; A=1-394, B/C=1-393, D=1-392 # PIR F64992 F64992 # PIRSF PIRSF000429 Ac-CoA_Ac_transf # PROSITE PS00098 THIOLASE_1 # PROSITE PS00099 THIOLASE_3 # PROSITE PS00737 THIOLASE_2 # Pfam PF00108 Thiolase_N # Pfam PF02803 Thiolase_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ATOB_ECOLI Acetyl-CoA acetyltransferase # RefSeq NP_416728 NC_000913.3 # RefSeq WP_000786547 NZ_LN832404.1 # SIMILARITY Belongs to the thiolase family. {ECO 0000305}. # SUBCELLULAR LOCATION ATOB_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF53901 SSF53901; 2 # TIGRFAMs TIGR01930 AcCoA-C-Actrans # UniPathway UPA00058 UER00101 # eggNOG COG0183 LUCA # eggNOG ENOG4105CHU Bacteria BLAST swissprot:ATOB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ATOB_ECOLI BioCyc ECOL316407:JW2218-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2218-MONOMER BioCyc EcoCyc:ACETYL-COA-ACETYLTRANSFER-MONOMER http://biocyc.org/getid?id=EcoCyc:ACETYL-COA-ACETYLTRANSFER-MONOMER BioCyc MetaCyc:ACETYL-COA-ACETYLTRANSFER-MONOMER http://biocyc.org/getid?id=MetaCyc:ACETYL-COA-ACETYLTRANSFER-MONOMER COG COG0183 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0183 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.9 http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.9 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.3.1.9 http://enzyme.expasy.org/EC/2.3.1.9 EchoBASE EB1623 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1623 EcoGene EG11672 http://www.ecogene.org/geneInfo.php?eg_id=EG11672 EnsemblBacteria AAC75284 http://www.ensemblgenomes.org/id/AAC75284 EnsemblBacteria AAC75284 http://www.ensemblgenomes.org/id/AAC75284 EnsemblBacteria BAA16020 http://www.ensemblgenomes.org/id/BAA16020 EnsemblBacteria BAA16020 http://www.ensemblgenomes.org/id/BAA16020 EnsemblBacteria BAA16020 http://www.ensemblgenomes.org/id/BAA16020 EnsemblBacteria b2224 http://www.ensemblgenomes.org/id/b2224 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003985 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003985 GO_function GO:0003988 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003988 GO_process GO:0006635 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006635 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.47.10 http://www.cathdb.info/version/latest/superfamily/3.40.47.10 GeneID 946727 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946727 HOGENOM HOG000012240 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000012240&db=HOGENOM6 InParanoid P76461 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76461 IntAct P76461 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76461* IntEnz 2.3.1.9 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.9 InterPro IPR002155 http://www.ebi.ac.uk/interpro/entry/IPR002155 InterPro IPR016039 http://www.ebi.ac.uk/interpro/entry/IPR016039 InterPro IPR020610 http://www.ebi.ac.uk/interpro/entry/IPR020610 InterPro IPR020613 http://www.ebi.ac.uk/interpro/entry/IPR020613 InterPro IPR020615 http://www.ebi.ac.uk/interpro/entry/IPR020615 InterPro IPR020616 http://www.ebi.ac.uk/interpro/entry/IPR020616 InterPro IPR020617 http://www.ebi.ac.uk/interpro/entry/IPR020617 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2218 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2218 KEGG_Gene eco:b2224 http://www.genome.jp/dbget-bin/www_bget?eco:b2224 KEGG_Orthology KO:K00626 http://www.genome.jp/dbget-bin/www_bget?KO:K00626 KEGG_Pathway ko00071 http://www.genome.jp/kegg-bin/show_pathway?ko00071 KEGG_Pathway ko00072 http://www.genome.jp/kegg-bin/show_pathway?ko00072 KEGG_Pathway ko00280 http://www.genome.jp/kegg-bin/show_pathway?ko00280 KEGG_Pathway ko00310 http://www.genome.jp/kegg-bin/show_pathway?ko00310 KEGG_Pathway ko00362 http://www.genome.jp/kegg-bin/show_pathway?ko00362 KEGG_Pathway ko00380 http://www.genome.jp/kegg-bin/show_pathway?ko00380 KEGG_Pathway ko00620 http://www.genome.jp/kegg-bin/show_pathway?ko00620 KEGG_Pathway ko00630 http://www.genome.jp/kegg-bin/show_pathway?ko00630 KEGG_Pathway ko00640 http://www.genome.jp/kegg-bin/show_pathway?ko00640 KEGG_Pathway ko00650 http://www.genome.jp/kegg-bin/show_pathway?ko00650 KEGG_Pathway ko00720 http://www.genome.jp/kegg-bin/show_pathway?ko00720 KEGG_Pathway ko00900 http://www.genome.jp/kegg-bin/show_pathway?ko00900 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 KEGG_Reaction rn:R00238 http://www.genome.jp/dbget-bin/www_bget?rn:R00238 KEGG_Reaction rn:R01177 http://www.genome.jp/dbget-bin/www_bget?rn:R01177 OMA CLSRAGW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CLSRAGW PDB 4WYS http://www.ebi.ac.uk/pdbe-srv/view/entry/4WYS PDB 5F0V http://www.ebi.ac.uk/pdbe-srv/view/entry/5F0V PDB 5F38 http://www.ebi.ac.uk/pdbe-srv/view/entry/5F38 PDBsum 4WYS http://www.ebi.ac.uk/pdbsum/4WYS PDBsum 5F0V http://www.ebi.ac.uk/pdbsum/5F0V PDBsum 5F38 http://www.ebi.ac.uk/pdbsum/5F38 PROSITE PS00098 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00098 PROSITE PS00099 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00099 PROSITE PS00737 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00737 PSORT swissprot:ATOB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ATOB_ECOLI PSORT-B swissprot:ATOB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ATOB_ECOLI PSORT2 swissprot:ATOB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ATOB_ECOLI Pfam PF00108 http://pfam.xfam.org/family/PF00108 Pfam PF02803 http://pfam.xfam.org/family/PF02803 Phobius swissprot:ATOB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ATOB_ECOLI PhylomeDB P76461 http://phylomedb.org/?seqid=P76461 ProteinModelPortal P76461 http://www.proteinmodelportal.org/query/uniprot/P76461 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416728 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416728 RefSeq WP_000786547 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000786547 SMR P76461 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76461 STRING 511145.b2224 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2224&targetmode=cogs STRING COG0183 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0183&targetmode=cogs SUPFAM SSF53901 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53901 TIGRFAMs TIGR01930 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01930 UniProtKB ATOB_ECOLI http://www.uniprot.org/uniprot/ATOB_ECOLI UniProtKB-AC P76461 http://www.uniprot.org/uniprot/P76461 charge swissprot:ATOB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ATOB_ECOLI eggNOG COG0183 http://eggnogapi.embl.de/nog_data/html/tree/COG0183 eggNOG ENOG4105CHU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CHU epestfind swissprot:ATOB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ATOB_ECOLI garnier swissprot:ATOB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ATOB_ECOLI helixturnhelix swissprot:ATOB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ATOB_ECOLI hmoment swissprot:ATOB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ATOB_ECOLI iep swissprot:ATOB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ATOB_ECOLI inforesidue swissprot:ATOB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ATOB_ECOLI octanol swissprot:ATOB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ATOB_ECOLI pepcoil swissprot:ATOB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ATOB_ECOLI pepdigest swissprot:ATOB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ATOB_ECOLI pepinfo swissprot:ATOB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ATOB_ECOLI pepnet swissprot:ATOB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ATOB_ECOLI pepstats swissprot:ATOB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ATOB_ECOLI pepwheel swissprot:ATOB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ATOB_ECOLI pepwindow swissprot:ATOB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ATOB_ECOLI sigcleave swissprot:ATOB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ATOB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260670 6 # EcoGene EG13262 ybbO # GO_function GO:0008106 alcohol dehydrogenase (NADP+) activity; IDA:EcoCyc. # GOslim_function GO:0016491 oxidoreductase activity # Gene3D 3.40.50.720 -; 1. # IntAct P0AFP4 9 # InterPro IPR002347 SDR_fam # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR020904 Sc_DH/Rdtase_CS # KEGG_Brite ko01000 Enzymes # Organism YBBO_ECOLI Escherichia coli (strain K12) # PANTHER PTHR24322 PTHR24322; 2 # PATRIC 32116145 VBIEscCol129921_0514 # PIR D64780 D64780 # PRINTS PR00081 GDHRDH # PROSITE PS00061 ADH_SHORT # Pfam PF00106 adh_short # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBBO_ECOLI Uncharacterized oxidoreductase YbbO # RefSeq NP_415026 NC_000913.3 # SIMILARITY Belongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO 0000305}. # SUPFAM SSF51735 SSF51735 # eggNOG COG1028 LUCA # eggNOG ENOG4105E1F Bacteria BLAST swissprot:YBBO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBBO_ECOLI BioCyc ECOL316407:JW0482-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0482-MONOMER BioCyc EcoCyc:G6269-MONOMER http://biocyc.org/getid?id=EcoCyc:G6269-MONOMER BioCyc MetaCyc:G6269-MONOMER http://biocyc.org/getid?id=MetaCyc:G6269-MONOMER DIP DIP-48139N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48139N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- EchoBASE EB3050 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3050 EcoGene EG13262 http://www.ecogene.org/geneInfo.php?eg_id=EG13262 EnsemblBacteria AAC73595 http://www.ensemblgenomes.org/id/AAC73595 EnsemblBacteria AAC73595 http://www.ensemblgenomes.org/id/AAC73595 EnsemblBacteria BAE76272 http://www.ensemblgenomes.org/id/BAE76272 EnsemblBacteria BAE76272 http://www.ensemblgenomes.org/id/BAE76272 EnsemblBacteria BAE76272 http://www.ensemblgenomes.org/id/BAE76272 EnsemblBacteria b0493 http://www.ensemblgenomes.org/id/b0493 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008106 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008106 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 945337 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945337 InParanoid P0AFP4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFP4 IntAct P0AFP4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFP4* IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR002347 http://www.ebi.ac.uk/interpro/entry/IPR002347 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR020904 http://www.ebi.ac.uk/interpro/entry/IPR020904 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0482 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0482 KEGG_Gene eco:b0493 http://www.genome.jp/dbget-bin/www_bget?eco:b0493 KEGG_Orthology KO:K00540 http://www.genome.jp/dbget-bin/www_bget?KO:K00540 OMA GHAIARM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GHAIARM PANTHER PTHR24322 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24322 PRINTS PR00081 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00081 PROSITE PS00061 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00061 PSORT swissprot:YBBO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBBO_ECOLI PSORT-B swissprot:YBBO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBBO_ECOLI PSORT2 swissprot:YBBO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBBO_ECOLI Pfam PF00106 http://pfam.xfam.org/family/PF00106 Phobius swissprot:YBBO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBBO_ECOLI PhylomeDB P0AFP4 http://phylomedb.org/?seqid=P0AFP4 ProteinModelPortal P0AFP4 http://www.proteinmodelportal.org/query/uniprot/P0AFP4 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415026 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415026 SMR P0AFP4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFP4 STRING 511145.b0493 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0493&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB YBBO_ECOLI http://www.uniprot.org/uniprot/YBBO_ECOLI UniProtKB-AC P0AFP4 http://www.uniprot.org/uniprot/P0AFP4 charge swissprot:YBBO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBBO_ECOLI eggNOG COG1028 http://eggnogapi.embl.de/nog_data/html/tree/COG1028 eggNOG ENOG4105E1F http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E1F epestfind swissprot:YBBO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBBO_ECOLI garnier swissprot:YBBO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBBO_ECOLI helixturnhelix swissprot:YBBO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBBO_ECOLI hmoment swissprot:YBBO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBBO_ECOLI iep swissprot:YBBO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBBO_ECOLI inforesidue swissprot:YBBO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBBO_ECOLI octanol swissprot:YBBO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBBO_ECOLI pepcoil swissprot:YBBO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBBO_ECOLI pepdigest swissprot:YBBO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBBO_ECOLI pepinfo swissprot:YBBO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBBO_ECOLI pepnet swissprot:YBBO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBBO_ECOLI pepstats swissprot:YBBO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBBO_ECOLI pepwheel swissprot:YBBO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBBO_ECOLI pepwindow swissprot:YBBO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBBO_ECOLI sigcleave swissprot:YBBO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBBO_ECOLI ## Database ID URL or Descriptions # BioGrid 4260968 19 # ESTHER ecoli-YfhR ABHD13-BEM46 # EcoGene EG13453 yfhR # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # Gene3D 3.40.50.1820 -; 1. # IntAct P77538 5 # InterPro IPR022742 Hydrolase_4 # InterPro IPR029058 AB_hydrolase # Organism YFHR_ECOLI Escherichia coli (strain K12) # PATRIC 32120465 VBIEscCol129921_2635 # PIR E65030 E65030 # Pfam PF12146 Hydrolase_4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFHR_ECOLI Uncharacterized protein YfhR # RefSeq NP_417029 NC_000913.3 # RefSeq WP_001297705 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA16428.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the serine esterase family. {ECO 0000305}. # SUBCELLULAR LOCATION YFHR_ECOLI Membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. # SUPFAM SSF53474 SSF53474 # eggNOG COG1073 LUCA # eggNOG ENOG4107XM9 Bacteria BLAST swissprot:YFHR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFHR_ECOLI BioCyc ECOL316407:JW2518-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2518-MONOMER BioCyc EcoCyc:G7328-MONOMER http://biocyc.org/getid?id=EcoCyc:G7328-MONOMER COG COG1073 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1073 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3226 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3226 EcoGene EG13453 http://www.ecogene.org/geneInfo.php?eg_id=EG13453 EnsemblBacteria AAC75587 http://www.ensemblgenomes.org/id/AAC75587 EnsemblBacteria AAC75587 http://www.ensemblgenomes.org/id/AAC75587 EnsemblBacteria BAA16428 http://www.ensemblgenomes.org/id/BAA16428 EnsemblBacteria BAA16428 http://www.ensemblgenomes.org/id/BAA16428 EnsemblBacteria BAA16428 http://www.ensemblgenomes.org/id/BAA16428 EnsemblBacteria b2534 http://www.ensemblgenomes.org/id/b2534 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 Gene3D 3.40.50.1820 http://www.cathdb.info/version/latest/superfamily/3.40.50.1820 GeneID 945059 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945059 HOGENOM HOG000007143 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000007143&db=HOGENOM6 InParanoid P77538 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77538 IntAct P77538 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77538* InterPro IPR022742 http://www.ebi.ac.uk/interpro/entry/IPR022742 InterPro IPR029058 http://www.ebi.ac.uk/interpro/entry/IPR029058 KEGG_Gene ecj:JW2518 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2518 KEGG_Gene eco:b2534 http://www.genome.jp/dbget-bin/www_bget?eco:b2534 KEGG_Orthology KO:K06889 http://www.genome.jp/dbget-bin/www_bget?KO:K06889 PSORT swissprot:YFHR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFHR_ECOLI PSORT-B swissprot:YFHR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFHR_ECOLI PSORT2 swissprot:YFHR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFHR_ECOLI Pfam PF12146 http://pfam.xfam.org/family/PF12146 Phobius swissprot:YFHR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFHR_ECOLI PhylomeDB P77538 http://phylomedb.org/?seqid=P77538 ProteinModelPortal P77538 http://www.proteinmodelportal.org/query/uniprot/P77538 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417029 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417029 RefSeq WP_001297705 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001297705 STRING 511145.b2534 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2534&targetmode=cogs STRING COG1073 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1073&targetmode=cogs SUPFAM SSF53474 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53474 UniProtKB YFHR_ECOLI http://www.uniprot.org/uniprot/YFHR_ECOLI UniProtKB-AC P77538 http://www.uniprot.org/uniprot/P77538 charge swissprot:YFHR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFHR_ECOLI eggNOG COG1073 http://eggnogapi.embl.de/nog_data/html/tree/COG1073 eggNOG ENOG4107XM9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107XM9 epestfind swissprot:YFHR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFHR_ECOLI garnier swissprot:YFHR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFHR_ECOLI helixturnhelix swissprot:YFHR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFHR_ECOLI hmoment swissprot:YFHR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFHR_ECOLI iep swissprot:YFHR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFHR_ECOLI inforesidue swissprot:YFHR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFHR_ECOLI octanol swissprot:YFHR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFHR_ECOLI pepcoil swissprot:YFHR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFHR_ECOLI pepdigest swissprot:YFHR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFHR_ECOLI pepinfo swissprot:YFHR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFHR_ECOLI pepnet swissprot:YFHR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFHR_ECOLI pepstats swissprot:YFHR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFHR_ECOLI pepwheel swissprot:YFHR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFHR_ECOLI pepwindow swissprot:YFHR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFHR_ECOLI sigcleave swissprot:YFHR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFHR_ECOLI ## Database ID URL or Descriptions # BioGrid 4261548 175 # CDD cd08071 MPN_DUF2466 # EcoGene EG13386 yeeS # InterPro IPR001405 RadC # InterPro IPR020891 UPF0758_CS # InterPro IPR025657 RadC_JAB # Organism YEES_ECOLI Escherichia coli (strain K12) # PATRIC 32119337 VBIEscCol129921_2078 # PIR A64965 A64965 # PROSITE PS01302 UPF0758 # Pfam PF04002 RadC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEES_ECOLI UPF0758 protein YeeS # RefSeq NP_416506 NC_000913.3 # RefSeq WP_000187523 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0758 family. {ECO 0000305}. # TIGRFAMs TIGR00608 radc # eggNOG COG2003 LUCA # eggNOG ENOG4108YGG Bacteria BLAST swissprot:YEES_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEES_ECOLI BioCyc ECOL316407:JW1984-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1984-MONOMER BioCyc EcoCyc:G7082-MONOMER http://biocyc.org/getid?id=EcoCyc:G7082-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3167 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3167 EcoGene EG13386 http://www.ecogene.org/geneInfo.php?eg_id=EG13386 EnsemblBacteria AAC75063 http://www.ensemblgenomes.org/id/AAC75063 EnsemblBacteria AAC75063 http://www.ensemblgenomes.org/id/AAC75063 EnsemblBacteria BAA15826 http://www.ensemblgenomes.org/id/BAA15826 EnsemblBacteria BAA15826 http://www.ensemblgenomes.org/id/BAA15826 EnsemblBacteria BAA15826 http://www.ensemblgenomes.org/id/BAA15826 EnsemblBacteria b2002 http://www.ensemblgenomes.org/id/b2002 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946514 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946514 HOGENOM HOG000273376 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000273376&db=HOGENOM6 InParanoid P76362 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76362 InterPro IPR001405 http://www.ebi.ac.uk/interpro/entry/IPR001405 InterPro IPR020891 http://www.ebi.ac.uk/interpro/entry/IPR020891 InterPro IPR025657 http://www.ebi.ac.uk/interpro/entry/IPR025657 KEGG_Gene ecj:JW1984 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1984 KEGG_Gene eco:b2002 http://www.genome.jp/dbget-bin/www_bget?eco:b2002 OMA HIVVGRT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HIVVGRT PROSITE PS01302 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01302 PSORT swissprot:YEES_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEES_ECOLI PSORT-B swissprot:YEES_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEES_ECOLI PSORT2 swissprot:YEES_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEES_ECOLI Pfam PF04002 http://pfam.xfam.org/family/PF04002 Phobius swissprot:YEES_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEES_ECOLI PhylomeDB P76362 http://phylomedb.org/?seqid=P76362 ProteinModelPortal P76362 http://www.proteinmodelportal.org/query/uniprot/P76362 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416506 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416506 RefSeq WP_000187523 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000187523 SMR P76362 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76362 STRING 511145.b2002 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2002&targetmode=cogs TIGRFAMs TIGR00608 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00608 UniProtKB YEES_ECOLI http://www.uniprot.org/uniprot/YEES_ECOLI UniProtKB-AC P76362 http://www.uniprot.org/uniprot/P76362 charge swissprot:YEES_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEES_ECOLI eggNOG COG2003 http://eggnogapi.embl.de/nog_data/html/tree/COG2003 eggNOG ENOG4108YGG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108YGG epestfind swissprot:YEES_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEES_ECOLI garnier swissprot:YEES_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEES_ECOLI helixturnhelix swissprot:YEES_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEES_ECOLI hmoment swissprot:YEES_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEES_ECOLI iep swissprot:YEES_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEES_ECOLI inforesidue swissprot:YEES_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEES_ECOLI octanol swissprot:YEES_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEES_ECOLI pepcoil swissprot:YEES_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEES_ECOLI pepdigest swissprot:YEES_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEES_ECOLI pepinfo swissprot:YEES_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEES_ECOLI pepnet swissprot:YEES_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEES_ECOLI pepstats swissprot:YEES_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEES_ECOLI pepwheel swissprot:YEES_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEES_ECOLI pepwindow swissprot:YEES_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEES_ECOLI sigcleave swissprot:YEES_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEES_ECOLI ## Database ID URL or Descriptions # BioGrid 4262085 9 # EcoGene EG11207 yjaB # GO_component GO:0031248 protein acetyltransferase complex; IBA:GO_Central. # GO_function GO:0004596 peptide alpha-N-acetyltransferase activity; IBA:GO_Central. # GO_process GO:0006474 N-terminal protein amino acid acetylation; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0006464 cellular protein modification process # Gene3D 3.40.630.30 -; 1. # InterPro IPR000182 GNAT_dom # InterPro IPR016181 Acyl_CoA_acyltransferase # KEGG_Brite ko01000 Enzymes # Organism YJAB_ECOLI Escherichia coli (strain K12) # PATRIC 32123551 VBIEscCol129921_4124 # PDB 2KCW NMR; -; A=1-147 # PIR B24340 Q3ECE6 # PROSITE PS51186 GNAT # Pfam PF13673 Acetyltransf_10 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJAB_ECOLI Uncharacterized N-acetyltransferase YjaB # RefSeq NP_418436 NC_000913.3 # RefSeq WP_000237004 NZ_LN832404.1 # SIMILARITY Belongs to the acetyltransferase family. {ECO 0000305}. # SIMILARITY Contains 1 N-acetyltransferase domain. {ECO:0000255|PROSITE-ProRule PRU00532}. # SUPFAM SSF55729 SSF55729 # eggNOG COG0454 LUCA # eggNOG ENOG4105K5X Bacteria BLAST swissprot:YJAB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJAB_ECOLI BioCyc ECOL316407:JW3972-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3972-MONOMER BioCyc EcoCyc:EG11207-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11207-MONOMER COG COG0454 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0454 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/13.15.5515 http://dx.doi.org/10.1093/nar/13.15.5515 DOI 10.1093/nar/19.8.1845 http://dx.doi.org/10.1093/nar/19.8.1845 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X02800 http://www.ebi.ac.uk/ena/data/view/X02800 EMBL X56780 http://www.ebi.ac.uk/ena/data/view/X56780 ENZYME 2.3.1.- http://enzyme.expasy.org/EC/2.3.1.- EchoBASE EB1192 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1192 EcoGene EG11207 http://www.ecogene.org/geneInfo.php?eg_id=EG11207 EnsemblBacteria AAC76982 http://www.ensemblgenomes.org/id/AAC76982 EnsemblBacteria AAC76982 http://www.ensemblgenomes.org/id/AAC76982 EnsemblBacteria BAE78014 http://www.ensemblgenomes.org/id/BAE78014 EnsemblBacteria BAE78014 http://www.ensemblgenomes.org/id/BAE78014 EnsemblBacteria BAE78014 http://www.ensemblgenomes.org/id/BAE78014 EnsemblBacteria b4012 http://www.ensemblgenomes.org/id/b4012 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0031248 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031248 GO_function GO:0004596 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004596 GO_process GO:0006474 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006474 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 Gene3D 3.40.630.30 http://www.cathdb.info/version/latest/superfamily/3.40.630.30 GeneID 948514 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948514 HOGENOM HOG000078517 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000078517&db=HOGENOM6 InParanoid P09163 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P09163 IntAct P09163 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P09163* IntEnz 2.3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1 InterPro IPR000182 http://www.ebi.ac.uk/interpro/entry/IPR000182 InterPro IPR016181 http://www.ebi.ac.uk/interpro/entry/IPR016181 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3972 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3972 KEGG_Gene eco:b4012 http://www.genome.jp/dbget-bin/www_bget?eco:b4012 KEGG_Orthology KO:K03827 http://www.genome.jp/dbget-bin/www_bget?KO:K03827 OMA VGFYKHM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VGFYKHM PDB 2KCW http://www.ebi.ac.uk/pdbe-srv/view/entry/2KCW PDBsum 2KCW http://www.ebi.ac.uk/pdbsum/2KCW PROSITE PS51186 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51186 PSORT swissprot:YJAB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJAB_ECOLI PSORT-B swissprot:YJAB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJAB_ECOLI PSORT2 swissprot:YJAB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJAB_ECOLI Pfam PF13673 http://pfam.xfam.org/family/PF13673 Phobius swissprot:YJAB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJAB_ECOLI PhylomeDB P09163 http://phylomedb.org/?seqid=P09163 ProteinModelPortal P09163 http://www.proteinmodelportal.org/query/uniprot/P09163 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1709493 http://www.ncbi.nlm.nih.gov/pubmed/1709493 PubMed 2412207 http://www.ncbi.nlm.nih.gov/pubmed/2412207 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418436 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418436 RefSeq WP_000237004 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000237004 SMR P09163 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P09163 STRING 511145.b4012 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4012&targetmode=cogs STRING COG0454 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0454&targetmode=cogs SUPFAM SSF55729 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55729 UniProtKB YJAB_ECOLI http://www.uniprot.org/uniprot/YJAB_ECOLI UniProtKB-AC P09163 http://www.uniprot.org/uniprot/P09163 charge swissprot:YJAB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJAB_ECOLI eggNOG COG0454 http://eggnogapi.embl.de/nog_data/html/tree/COG0454 eggNOG ENOG4105K5X http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K5X epestfind swissprot:YJAB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJAB_ECOLI garnier swissprot:YJAB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJAB_ECOLI helixturnhelix swissprot:YJAB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJAB_ECOLI hmoment swissprot:YJAB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJAB_ECOLI iep swissprot:YJAB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJAB_ECOLI inforesidue swissprot:YJAB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJAB_ECOLI octanol swissprot:YJAB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJAB_ECOLI pepcoil swissprot:YJAB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJAB_ECOLI pepdigest swissprot:YJAB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJAB_ECOLI pepinfo swissprot:YJAB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJAB_ECOLI pepnet swissprot:YJAB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJAB_ECOLI pepstats swissprot:YJAB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJAB_ECOLI pepwheel swissprot:YJAB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJAB_ECOLI pepwindow swissprot:YJAB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJAB_ECOLI sigcleave swissprot:YJAB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJAB_ECOLI ## Database ID URL or Descriptions # AltName CYNS_ECOLI Cyanate hydrolase # AltName CYNS_ECOLI Cyanate lyase # BioGrid 4263187 4 # CATALYTIC ACTIVITY CYNS_ECOLI Cyanate + HCO(3)(-) + 2 H(+) = NH(3) + 2 CO(2). # CDD cd00559 Cyanase_C # EcoGene EG10175 cynS # FUNCTION CYNS_ECOLI Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_function GO:0008824 cyanate hydratase activity; IDA:EcoCyc. # GO_process GO:0009440 cyanate catabolic process; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.260.40 -; 1. # Gene3D 3.30.1160.10 -; 1. # HAMAP MF_00535 Cyanate_hydrat # IntAct P00816 3 # InterPro IPR003712 Cyanate_lyase_C # InterPro IPR008076 Cyanase # InterPro IPR010982 Lambda_DNA-bd_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00910 Nitrogen metabolism # Organism CYNS_ECOLI Escherichia coli (strain K12) # PATRIC 32115813 VBIEscCol129921_0348 # PDB 1DW9 X-ray; 1.65 A; A/B/C/D/E/F/G/H/I/J=1-156 # PDB 1DWK X-ray; 1.65 A; A/B/C/D/E/F/G/H/I/J=1-156 # PDB 2IU7 X-ray; 1.91 A; A/B/C/D/E/F/G/H/I/J=1-156 # PDB 2IUO X-ray; 1.90 A; A/B/C/D/E/F/G/H/I/J=1-156 # PDB 2IV1 X-ray; 1.88 A; A/B/C/D/E/F/G/H/I/J=1-156 # PDB 2IVB X-ray; 1.95 A; A/B/C/D/E/F/G/H/I/J=1-156 # PDB 2IVG X-ray; 1.87 A; A/B/C/D/E/F/G/H/I/J=1-156 # PDB 2IVQ X-ray; 2.10 A; A/B/C/D/E/F/G/H/I/J=1-156 # PIR A91850 YNEC # PIRSF PIRSF001263 Cyanate_hydratas # PRINTS PR01693 CYANASE # Pfam PF02560 Cyanate_lyase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CYNS_ECOLI Cyanate hydratase # RefSeq NP_414874 NC_000913.3 # RefSeq WP_000616243 NZ_LN832404.1 # SIMILARITY Belongs to the cyanase family. {ECO 0000305}. # SMART SM01116 Cyanate_lyase # SUBUNIT CYNS_ECOLI Homodecamer composed of five homodimers. # SUPFAM SSF47413 SSF47413 # SUPFAM SSF55234 SSF55234 # TIGRFAMs TIGR00673 cynS # eggNOG COG1513 LUCA # eggNOG ENOG4108V7B Bacteria BLAST swissprot:CYNS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CYNS_ECOLI BioCyc ECOL316407:JW0331-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0331-MONOMER BioCyc EcoCyc:CYANLY-MONOMER http://biocyc.org/getid?id=EcoCyc:CYANLY-MONOMER BioCyc MetaCyc:CYANLY-MONOMER http://biocyc.org/getid?id=MetaCyc:CYANLY-MONOMER COG COG1513 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1513 DIP DIP-9365N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9365N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/S0969-2126(00)00134-9 http://dx.doi.org/10.1016/S0969-2126(00)00134-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.1.104 http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.104 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M17891 http://www.ebi.ac.uk/ena/data/view/M17891 EMBL M23219 http://www.ebi.ac.uk/ena/data/view/M23219 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 ENZYME 4.2.1.104 http://enzyme.expasy.org/EC/4.2.1.104 EchoBASE EB0172 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0172 EcoGene EG10175 http://www.ecogene.org/geneInfo.php?eg_id=EG10175 EnsemblBacteria AAC73443 http://www.ensemblgenomes.org/id/AAC73443 EnsemblBacteria AAC73443 http://www.ensemblgenomes.org/id/AAC73443 EnsemblBacteria BAE76122 http://www.ensemblgenomes.org/id/BAE76122 EnsemblBacteria BAE76122 http://www.ensemblgenomes.org/id/BAE76122 EnsemblBacteria BAE76122 http://www.ensemblgenomes.org/id/BAE76122 EnsemblBacteria b0340 http://www.ensemblgenomes.org/id/b0340 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0008824 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008824 GO_process GO:0009440 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009440 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.260.40 http://www.cathdb.info/version/latest/superfamily/1.10.260.40 Gene3D 3.30.1160.10 http://www.cathdb.info/version/latest/superfamily/3.30.1160.10 GeneID 948998 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948998 HAMAP MF_00535 http://hamap.expasy.org/unirule/MF_00535 HOGENOM HOG000043436 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000043436&db=HOGENOM6 InParanoid P00816 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00816 IntAct P00816 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00816* IntEnz 4.2.1.104 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.104 InterPro IPR003712 http://www.ebi.ac.uk/interpro/entry/IPR003712 InterPro IPR008076 http://www.ebi.ac.uk/interpro/entry/IPR008076 InterPro IPR010982 http://www.ebi.ac.uk/interpro/entry/IPR010982 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0331 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0331 KEGG_Gene eco:b0340 http://www.genome.jp/dbget-bin/www_bget?eco:b0340 KEGG_Orthology KO:K01725 http://www.genome.jp/dbget-bin/www_bget?KO:K01725 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Reaction rn:R03546 http://www.genome.jp/dbget-bin/www_bget?rn:R03546 KEGG_Reaction rn:R10079 http://www.genome.jp/dbget-bin/www_bget?rn:R10079 OMA PMKDVIQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PMKDVIQ PDB 1DW9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1DW9 PDB 1DWK http://www.ebi.ac.uk/pdbe-srv/view/entry/1DWK PDB 2IU7 http://www.ebi.ac.uk/pdbe-srv/view/entry/2IU7 PDB 2IUO http://www.ebi.ac.uk/pdbe-srv/view/entry/2IUO PDB 2IV1 http://www.ebi.ac.uk/pdbe-srv/view/entry/2IV1 PDB 2IVB http://www.ebi.ac.uk/pdbe-srv/view/entry/2IVB PDB 2IVG http://www.ebi.ac.uk/pdbe-srv/view/entry/2IVG PDB 2IVQ http://www.ebi.ac.uk/pdbe-srv/view/entry/2IVQ PDBsum 1DW9 http://www.ebi.ac.uk/pdbsum/1DW9 PDBsum 1DWK http://www.ebi.ac.uk/pdbsum/1DWK PDBsum 2IU7 http://www.ebi.ac.uk/pdbsum/2IU7 PDBsum 2IUO http://www.ebi.ac.uk/pdbsum/2IUO PDBsum 2IV1 http://www.ebi.ac.uk/pdbsum/2IV1 PDBsum 2IVB http://www.ebi.ac.uk/pdbsum/2IVB PDBsum 2IVG http://www.ebi.ac.uk/pdbsum/2IVG PDBsum 2IVQ http://www.ebi.ac.uk/pdbsum/2IVQ PRINTS PR01693 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01693 PSORT swissprot:CYNS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CYNS_ECOLI PSORT-B swissprot:CYNS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CYNS_ECOLI PSORT2 swissprot:CYNS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CYNS_ECOLI Pfam PF02560 http://pfam.xfam.org/family/PF02560 Phobius swissprot:CYNS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CYNS_ECOLI PhylomeDB P00816 http://phylomedb.org/?seqid=P00816 ProteinModelPortal P00816 http://www.proteinmodelportal.org/query/uniprot/P00816 PubMed 10801492 http://www.ncbi.nlm.nih.gov/pubmed/10801492 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2822670 http://www.ncbi.nlm.nih.gov/pubmed/2822670 PubMed 3049588 http://www.ncbi.nlm.nih.gov/pubmed/3049588 PubMed 3301828 http://www.ncbi.nlm.nih.gov/pubmed/3301828 PubMed 6336748 http://www.ncbi.nlm.nih.gov/pubmed/6336748 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_414874 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414874 RefSeq WP_000616243 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000616243 SMART SM01116 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01116 SMR P00816 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00816 STRING 511145.b0340 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0340&targetmode=cogs STRING COG1513 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1513&targetmode=cogs SUPFAM SSF47413 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47413 SUPFAM SSF55234 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55234 TIGRFAMs TIGR00673 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00673 UniProtKB CYNS_ECOLI http://www.uniprot.org/uniprot/CYNS_ECOLI UniProtKB-AC P00816 http://www.uniprot.org/uniprot/P00816 charge swissprot:CYNS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CYNS_ECOLI eggNOG COG1513 http://eggnogapi.embl.de/nog_data/html/tree/COG1513 eggNOG ENOG4108V7B http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108V7B epestfind swissprot:CYNS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CYNS_ECOLI garnier swissprot:CYNS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CYNS_ECOLI helixturnhelix swissprot:CYNS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CYNS_ECOLI hmoment swissprot:CYNS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CYNS_ECOLI iep swissprot:CYNS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CYNS_ECOLI inforesidue swissprot:CYNS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CYNS_ECOLI octanol swissprot:CYNS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CYNS_ECOLI pepcoil swissprot:CYNS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CYNS_ECOLI pepdigest swissprot:CYNS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CYNS_ECOLI pepinfo swissprot:CYNS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CYNS_ECOLI pepnet swissprot:CYNS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CYNS_ECOLI pepstats swissprot:CYNS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CYNS_ECOLI pepwheel swissprot:CYNS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CYNS_ECOLI pepwindow swissprot:CYNS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CYNS_ECOLI sigcleave swissprot:CYNS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CYNS_ECOLI ## Database ID URL or Descriptions # BioGrid 4259484 4 # DISRUPTION PHENOTYPE Has no effect on leucine biosynthesis nor on bgl operon silencing. {ECO:0000269|PubMed 9422614}. # EcoGene EG10531 leuO # FUNCTION LEUO_ECOLI A global transcription factor. Activates transcription of the 9 following operons; yjjQ-bglJ, yjjP, acrEF, ybdO, yjcRQP, casABCDE12, rhsD-ybbC, fepE and gltF, in most cases it probably interferes with silencing by H-NS and activates transcription. Represses transcription of the 3 following operons; uxaCA, sdaCB and yjiY. H-NS repression of the bgl operon, leading to the ability to metabolize some beta-glucosides. It also directly activates the bgl operon. Activation is H-NS and BglJ-RcsB independent. {ECO 0000269|PubMed 19429622, ECO 0000269|PubMed 20659289, ECO 0000269|PubMed 20952573, ECO 0000269|PubMed 9422614}. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IMP:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # INDUCTION Gene expression is repressed by H-NS, activated by itself. More highly expressed in minimal than rich medium, poorly expressed in exoponential growth, levels increase in stationary phase (at protein level). {ECO:0000269|PubMed 19429622}. # IntAct P10151 5 # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR005119 LysR_subst-bd # InterPro IPR011991 WHTH_DNA-bd_dom # KEGG_Brite ko03000 Transcription factors # Organism LEUO_ECOLI Escherichia coli (strain K12) # PATRIC 32115255 VBIEscCol129921_0079 # PIR D64729 D64729 # PRINTS PR00039 HTHLYSR # PROSITE PS50931 HTH_LYSR # Pfam PF00126 HTH_1 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LEUO_ECOLI HTH-type transcriptional regulator LeuO # RefSeq NP_414618 NC_000913.3 # RefSeq WP_001115472 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA83880.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA38853.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Contains 1 HTH lysR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00253}. # SUPFAM SSF46785 SSF46785 # eggNOG ENOG41064T2 Bacteria # eggNOG ENOG4110BBF LUCA BLAST swissprot:LEUO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LEUO_ECOLI BioCyc ECOL316407:JW0075-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0075-MONOMER BioCyc EcoCyc:PD00519 http://biocyc.org/getid?id=EcoCyc:PD00519 COG COG0583 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0583 DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.85.18.6602 http://dx.doi.org/10.1073/pnas.85.18.6602 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1111/j.1365-2958.2010.07315.x http://dx.doi.org/10.1111/j.1365-2958.2010.07315.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00108-09 http://dx.doi.org/10.1128/JB.00108-09 DOI 10.1128/JB.00807-10 http://dx.doi.org/10.1128/JB.00807-10 DOI 10.1128/JB.01447-07 http://dx.doi.org/10.1128/JB.01447-07 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M12891 http://www.ebi.ac.uk/ena/data/view/M12891 EMBL M21150 http://www.ebi.ac.uk/ena/data/view/M21150 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X55034 http://www.ebi.ac.uk/ena/data/view/X55034 EchoBASE EB0526 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0526 EcoGene EG10531 http://www.ecogene.org/geneInfo.php?eg_id=EG10531 EnsemblBacteria AAC73187 http://www.ensemblgenomes.org/id/AAC73187 EnsemblBacteria AAC73187 http://www.ensemblgenomes.org/id/AAC73187 EnsemblBacteria BAB96645 http://www.ensemblgenomes.org/id/BAB96645 EnsemblBacteria BAB96645 http://www.ensemblgenomes.org/id/BAB96645 EnsemblBacteria BAB96645 http://www.ensemblgenomes.org/id/BAB96645 EnsemblBacteria b0076 http://www.ensemblgenomes.org/id/b0076 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 949034 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949034 HOGENOM HOG000116777 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000116777&db=HOGENOM6 InParanoid P10151 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P10151 IntAct P10151 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P10151* InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW0075 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0075 KEGG_Gene eco:b0076 http://www.genome.jp/dbget-bin/www_bget?eco:b0076 KEGG_Orthology KO:K05798 http://www.genome.jp/dbget-bin/www_bget?KO:K05798 OMA APNIHLV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=APNIHLV PRINTS PR00039 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00039 PROSITE PS50931 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50931 PSORT swissprot:LEUO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LEUO_ECOLI PSORT-B swissprot:LEUO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LEUO_ECOLI PSORT2 swissprot:LEUO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LEUO_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:LEUO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LEUO_ECOLI PhylomeDB P10151 http://phylomedb.org/?seqid=P10151 ProteinModelPortal P10151 http://www.proteinmodelportal.org/query/uniprot/P10151 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18055596 http://www.ncbi.nlm.nih.gov/pubmed/18055596 PubMed 19429622 http://www.ncbi.nlm.nih.gov/pubmed/19429622 PubMed 20659289 http://www.ncbi.nlm.nih.gov/pubmed/20659289 PubMed 20952573 http://www.ncbi.nlm.nih.gov/pubmed/20952573 PubMed 3413113 http://www.ncbi.nlm.nih.gov/pubmed/3413113 PubMed 3519576 http://www.ncbi.nlm.nih.gov/pubmed/3519576 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9422614 http://www.ncbi.nlm.nih.gov/pubmed/9422614 RefSeq NP_414618 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414618 RefSeq WP_001115472 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001115472 SMR P10151 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P10151 STRING 511145.b0076 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0076&targetmode=cogs STRING COG0583 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0583&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB LEUO_ECOLI http://www.uniprot.org/uniprot/LEUO_ECOLI UniProtKB-AC P10151 http://www.uniprot.org/uniprot/P10151 charge swissprot:LEUO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LEUO_ECOLI eggNOG ENOG41064T2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41064T2 eggNOG ENOG4110BBF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4110BBF epestfind swissprot:LEUO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LEUO_ECOLI garnier swissprot:LEUO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LEUO_ECOLI helixturnhelix swissprot:LEUO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LEUO_ECOLI hmoment swissprot:LEUO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LEUO_ECOLI iep swissprot:LEUO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LEUO_ECOLI inforesidue swissprot:LEUO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LEUO_ECOLI octanol swissprot:LEUO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LEUO_ECOLI pepcoil swissprot:LEUO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LEUO_ECOLI pepdigest swissprot:LEUO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LEUO_ECOLI pepinfo swissprot:LEUO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LEUO_ECOLI pepnet swissprot:LEUO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LEUO_ECOLI pepstats swissprot:LEUO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LEUO_ECOLI pepwheel swissprot:LEUO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LEUO_ECOLI pepwindow swissprot:LEUO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LEUO_ECOLI sigcleave swissprot:LEUO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LEUO_ECOLI ## Database ID URL or Descriptions # BioGrid 4261192 4 # EcoGene EG11431 yfeC # Gene3D 1.10.10.10 -; 1. # InterPro IPR009061 DNA-bd_dom_put # InterPro IPR010749 DUF1323 # InterPro IPR011991 WHTH_DNA-bd_dom # Organism YFEC_ECOLI Escherichia coli (strain K12) # PATRIC 32120173 VBIEscCol129921_2493 # Pfam PF07037 DUF1323 # ProDom PD060594 DUF1323 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFEC_ECOLI Uncharacterized protein YfeC # RefSeq NP_416897 NC_000913.3 # RefSeq WP_001296278 NZ_LN832404.1 # SIMILARITY To E.coli YfiI and P.aeruginosa RluD. {ECO 0000305}. # SUPFAM SSF46955 SSF46955 # eggNOG ENOG4105HZG Bacteria # eggNOG ENOG4111QX4 LUCA BLAST swissprot:YFEC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFEC_ECOLI BioCyc ECOL316407:JW2393-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2393-MONOMER BioCyc EcoCyc:EG11431-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11431-MONOMER DIP DIP-12012N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12012N DOI 10.1016/0022-2836(90)90339-N http://dx.doi.org/10.1016/0022-2836(90)90339-N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M13687 http://www.ebi.ac.uk/ena/data/view/M13687 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X63976 http://www.ebi.ac.uk/ena/data/view/X63976 EchoBASE EB1401 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1401 EcoGene EG11431 http://www.ecogene.org/geneInfo.php?eg_id=EG11431 EnsemblBacteria AAC75455 http://www.ensemblgenomes.org/id/AAC75455 EnsemblBacteria AAC75455 http://www.ensemblgenomes.org/id/AAC75455 EnsemblBacteria BAA16269 http://www.ensemblgenomes.org/id/BAA16269 EnsemblBacteria BAA16269 http://www.ensemblgenomes.org/id/BAA16269 EnsemblBacteria BAA16269 http://www.ensemblgenomes.org/id/BAA16269 EnsemblBacteria b2398 http://www.ensemblgenomes.org/id/b2398 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 946857 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946857 HOGENOM HOG000122974 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122974&db=HOGENOM6 InterPro IPR009061 http://www.ebi.ac.uk/interpro/entry/IPR009061 InterPro IPR010749 http://www.ebi.ac.uk/interpro/entry/IPR010749 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW2393 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2393 KEGG_Gene eco:b2398 http://www.genome.jp/dbget-bin/www_bget?eco:b2398 OMA DELAHYT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DELAHYT PSORT swissprot:YFEC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFEC_ECOLI PSORT-B swissprot:YFEC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFEC_ECOLI PSORT2 swissprot:YFEC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFEC_ECOLI Pfam PF07037 http://pfam.xfam.org/family/PF07037 Phobius swissprot:YFEC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFEC_ECOLI ProteinModelPortal P0AD37 http://www.proteinmodelportal.org/query/uniprot/P0AD37 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2201776 http://www.ncbi.nlm.nih.gov/pubmed/2201776 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416897 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416897 RefSeq WP_001296278 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001296278 SMR P0AD37 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AD37 STRING 511145.b2398 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2398&targetmode=cogs SUPFAM SSF46955 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46955 UniProtKB YFEC_ECOLI http://www.uniprot.org/uniprot/YFEC_ECOLI UniProtKB-AC P0AD37 http://www.uniprot.org/uniprot/P0AD37 charge swissprot:YFEC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFEC_ECOLI eggNOG ENOG4105HZG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105HZG eggNOG ENOG4111QX4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111QX4 epestfind swissprot:YFEC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFEC_ECOLI garnier swissprot:YFEC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFEC_ECOLI helixturnhelix swissprot:YFEC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFEC_ECOLI hmoment swissprot:YFEC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFEC_ECOLI iep swissprot:YFEC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFEC_ECOLI inforesidue swissprot:YFEC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFEC_ECOLI octanol swissprot:YFEC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFEC_ECOLI pepcoil swissprot:YFEC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFEC_ECOLI pepdigest swissprot:YFEC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFEC_ECOLI pepinfo swissprot:YFEC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFEC_ECOLI pepnet swissprot:YFEC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFEC_ECOLI pepstats swissprot:YFEC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFEC_ECOLI pepwheel swissprot:YFEC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFEC_ECOLI pepwindow swissprot:YFEC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFEC_ECOLI sigcleave swissprot:YFEC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFEC_ECOLI ## Database ID URL or Descriptions # BioGrid 4259816 15 # CDD cd00383 trans_reg_C # EcoGene EG10728 phoB # FUNCTION PHOB_ECOLI This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0000156 phosphorelay response regulator activity; IEA:InterPro. # GO_function GO:0001108 bacterial-type RNA polymerase holo enzyme binding; IMP:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0042802 identical protein binding; IPI:IntAct. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006817 phosphate ion transport; IEA:UniProtKB-KW. # GO_process GO:2000142 regulation of DNA-templated transcription, initiation; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004871 signal transducer activity # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # INTERACTION PHOB_ECOLI Self; NbExp=5; IntAct=EBI-1116564, EBI-1116564; # IntAct P0AFJ5 24 # InterPro IPR001789 Sig_transdc_resp-reg_receiver # InterPro IPR001867 OmpR/PhoB-type_DNA-bd # InterPro IPR011006 CheY-like_superfamily # InterPro IPR011879 Sig_transdc_resp-reg_PhoB # InterPro IPR011991 WHTH_DNA-bd_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02022 M00434 PhoR-PhoB (phosphate starvation response) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # Organism PHOB_ECOLI Escherichia coli (strain K12) # PATRIC 32115943 VBIEscCol129921_0413 # PDB 1B00 X-ray; 1.88 A; A/B=1-127 # PDB 1GXP X-ray; 2.50 A; A/B/E/F=124-229 # PDB 1GXQ X-ray; 2.00 A; A=124-229 # PDB 1QQI NMR; -; A=126-229 # PDB 1ZES X-ray; 1.90 A; A/B/C=1-125 # PDB 2IYN X-ray; 2.08 A; A/B/C=1-127 # PDB 2JB9 X-ray; 1.70 A; A/B=1-127 # PDB 2JBA X-ray; 1.45 A; A/B=1-127 # PDB 2Z33 NMR; -; A=126-229 # PDB 3T72 X-ray; 4.33 A; 1/4/5/8/9/A/B/E/F/I/J/M/N/R/S/V/W/Z/c/d/g/h/k/l=128-229 # PIR A24256 RGECFB # PROSITE PS50110 RESPONSE_REGULATORY # PROSITE PS51755 OMPR_PHOB # PTM PHOB_ECOLI Phosphorylated by PhoR or CreC. {ECO 0000269|PubMed 9878437}. # Pfam PF00072 Response_reg # Pfam PF00486 Trans_reg_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PHOB_ECOLI Phosphate regulon transcriptional regulatory protein PhoB # RefSeq NP_414933 NC_000913.3 # RefSeq WP_000113933 NZ_LN832404.1 # SIMILARITY Contains 1 OmpR/PhoB-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU01091}. # SIMILARITY Contains 1 response regulatory domain. {ECO:0000255|PROSITE-ProRule PRU00169}. # SMART SM00448 REC # SMART SM00862 Trans_reg_C # SUBCELLULAR LOCATION PHOB_ECOLI Cytoplasm. # SUPFAM SSF52172 SSF52172 # TIGRFAMs TIGR02154 PhoB # eggNOG COG0745 LUCA # eggNOG ENOG4105CK6 Bacteria BLAST swissprot:PHOB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PHOB_ECOLI BioCyc ECOL316407:JW0389-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0389-MONOMER BioCyc EcoCyc:PHOB-MONOMER http://biocyc.org/getid?id=EcoCyc:PHOB-MONOMER COG COG0745 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0745 DIP DIP-35852N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35852N DOI 10.1006/jmbi.1998.2326 http://dx.doi.org/10.1006/jmbi.1998.2326 DOI 10.1006/jmbi.1999.3379 http://dx.doi.org/10.1006/jmbi.1999.3379 DOI 10.1016/0022-2836(86)90073-2 http://dx.doi.org/10.1016/0022-2836(86)90073-2 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EMBL X04026 http://www.ebi.ac.uk/ena/data/view/X04026 EchoBASE EB0721 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0721 EcoGene EG10728 http://www.ecogene.org/geneInfo.php?eg_id=EG10728 EnsemblBacteria AAC73502 http://www.ensemblgenomes.org/id/AAC73502 EnsemblBacteria AAC73502 http://www.ensemblgenomes.org/id/AAC73502 EnsemblBacteria BAE76179 http://www.ensemblgenomes.org/id/BAE76179 EnsemblBacteria BAE76179 http://www.ensemblgenomes.org/id/BAE76179 EnsemblBacteria BAE76179 http://www.ensemblgenomes.org/id/BAE76179 EnsemblBacteria b0399 http://www.ensemblgenomes.org/id/b0399 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000156 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000156 GO_function GO:0001108 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001108 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006817 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006817 GO_process GO:2000142 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000142 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 945046 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945046 HOGENOM HOG000034819 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000034819&db=HOGENOM6 InParanoid P0AFJ5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFJ5 IntAct P0AFJ5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFJ5* InterPro IPR001789 http://www.ebi.ac.uk/interpro/entry/IPR001789 InterPro IPR001867 http://www.ebi.ac.uk/interpro/entry/IPR001867 InterPro IPR011006 http://www.ebi.ac.uk/interpro/entry/IPR011006 InterPro IPR011879 http://www.ebi.ac.uk/interpro/entry/IPR011879 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW0389 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0389 KEGG_Gene eco:b0399 http://www.genome.jp/dbget-bin/www_bget?eco:b0399 KEGG_Orthology KO:K07657 http://www.genome.jp/dbget-bin/www_bget?KO:K07657 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 MINT MINT-1313174 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1313174 OMA MAMRYEG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MAMRYEG PDB 1B00 http://www.ebi.ac.uk/pdbe-srv/view/entry/1B00 PDB 1GXP http://www.ebi.ac.uk/pdbe-srv/view/entry/1GXP PDB 1GXQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1GXQ PDB 1QQI http://www.ebi.ac.uk/pdbe-srv/view/entry/1QQI PDB 1ZES http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZES PDB 2IYN http://www.ebi.ac.uk/pdbe-srv/view/entry/2IYN PDB 2JB9 http://www.ebi.ac.uk/pdbe-srv/view/entry/2JB9 PDB 2JBA http://www.ebi.ac.uk/pdbe-srv/view/entry/2JBA PDB 2Z33 http://www.ebi.ac.uk/pdbe-srv/view/entry/2Z33 PDB 3T72 http://www.ebi.ac.uk/pdbe-srv/view/entry/3T72 PDBsum 1B00 http://www.ebi.ac.uk/pdbsum/1B00 PDBsum 1GXP http://www.ebi.ac.uk/pdbsum/1GXP PDBsum 1GXQ http://www.ebi.ac.uk/pdbsum/1GXQ PDBsum 1QQI http://www.ebi.ac.uk/pdbsum/1QQI PDBsum 1ZES http://www.ebi.ac.uk/pdbsum/1ZES PDBsum 2IYN http://www.ebi.ac.uk/pdbsum/2IYN PDBsum 2JB9 http://www.ebi.ac.uk/pdbsum/2JB9 PDBsum 2JBA http://www.ebi.ac.uk/pdbsum/2JBA PDBsum 2Z33 http://www.ebi.ac.uk/pdbsum/2Z33 PDBsum 3T72 http://www.ebi.ac.uk/pdbsum/3T72 PROSITE PS50110 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50110 PROSITE PS51755 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51755 PSORT swissprot:PHOB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PHOB_ECOLI PSORT-B swissprot:PHOB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PHOB_ECOLI PSORT2 swissprot:PHOB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PHOB_ECOLI Pfam PF00072 http://pfam.xfam.org/family/PF00072 Pfam PF00486 http://pfam.xfam.org/family/PF00486 Phobius swissprot:PHOB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PHOB_ECOLI PhylomeDB P0AFJ5 http://phylomedb.org/?seqid=P0AFJ5 ProteinModelPortal P0AFJ5 http://www.proteinmodelportal.org/query/uniprot/P0AFJ5 PubMed 10653699 http://www.ncbi.nlm.nih.gov/pubmed/10653699 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3537313 http://www.ncbi.nlm.nih.gov/pubmed/3537313 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9878437 http://www.ncbi.nlm.nih.gov/pubmed/9878437 RefSeq NP_414933 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414933 RefSeq WP_000113933 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000113933 SMART SM00448 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00448 SMART SM00862 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00862 SMR P0AFJ5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFJ5 STRING 511145.b0399 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0399&targetmode=cogs STRING COG0745 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0745&targetmode=cogs SUPFAM SSF52172 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52172 TIGRFAMs TIGR02154 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02154 UniProtKB PHOB_ECOLI http://www.uniprot.org/uniprot/PHOB_ECOLI UniProtKB-AC P0AFJ5 http://www.uniprot.org/uniprot/P0AFJ5 charge swissprot:PHOB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PHOB_ECOLI eggNOG COG0745 http://eggnogapi.embl.de/nog_data/html/tree/COG0745 eggNOG ENOG4105CK6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CK6 epestfind swissprot:PHOB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PHOB_ECOLI garnier swissprot:PHOB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PHOB_ECOLI helixturnhelix swissprot:PHOB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PHOB_ECOLI hmoment swissprot:PHOB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PHOB_ECOLI iep swissprot:PHOB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PHOB_ECOLI inforesidue swissprot:PHOB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PHOB_ECOLI octanol swissprot:PHOB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PHOB_ECOLI pepcoil swissprot:PHOB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PHOB_ECOLI pepdigest swissprot:PHOB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PHOB_ECOLI pepinfo swissprot:PHOB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PHOB_ECOLI pepnet swissprot:PHOB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PHOB_ECOLI pepstats swissprot:PHOB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PHOB_ECOLI pepwheel swissprot:PHOB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PHOB_ECOLI pepwindow swissprot:PHOB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PHOB_ECOLI sigcleave swissprot:PHOB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PHOB_ECOLI ## Database ID URL or Descriptions # AltName YDEK_ECOLI ORFT # BioGrid 4260223 321 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG11780 ydeK # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GOslim_component GO:0005886 plasma membrane # Gene3D 2.160.20.20 -; 1. # InterPro IPR011050 Pectin_lyase_fold/virulence # InterPro IPR012332 P22_tailspike_C-like # InterPro IPR013425 Autotrns_rpt # InterPro IPR024973 ESPR # InterPro IPR030895 T5SS_PEPC_rpt # Organism YDEK_ECOLI Escherichia coli (strain K12) # PATRIC 48662334 VBIEscCol107702_1528 # PIR A64905 A64905 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF13018 ESPR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDEK_ECOLI Uncharacterized lipoprotein YdeK # RefSeq WP_011443591 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA51730.1; Type=Frameshift; Positions=653; Evidence={ECO 0000305}; # SIMILARITY To E.coli YfaL. {ECO 0000305}. # SUBCELLULAR LOCATION YDEK_ECOLI Cell membrane {ECO 0000255|PROSITE- ProRule PRU00303}; Lipid-anchor {ECO 0000255|PROSITE- ProRule PRU00303}. # SUPFAM SSF51126 SSF51126 # TIGRFAMs TIGR02601 autotrns_rpt; 2 # TIGRFAMs TIGR04393 rpt_T5SS_PEPC; 7 BLAST swissprot:YDEK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDEK_ECOLI BioCyc ECOL316407:JW1503-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1503-MONOMER BioCyc EcoCyc:EG11780-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11780-MONOMER DOI 10.1016/0005-2736(93)90425-Y http://dx.doi.org/10.1016/0005-2736(93)90425-Y DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X73295 http://www.ebi.ac.uk/ena/data/view/X73295 EchoBASE EB1728 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1728 EcoGene EG11780 http://www.ecogene.org/geneInfo.php?eg_id=EG11780 EnsemblBacteria BAA15190 http://www.ensemblgenomes.org/id/BAA15190 EnsemblBacteria BAA15190 http://www.ensemblgenomes.org/id/BAA15190 EnsemblBacteria BAA15190 http://www.ensemblgenomes.org/id/BAA15190 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 Gene3D 2.160.20.20 http://www.cathdb.info/version/latest/superfamily/2.160.20.20 HOGENOM HOG000009465 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009465&db=HOGENOM6 InterPro IPR011050 http://www.ebi.ac.uk/interpro/entry/IPR011050 InterPro IPR012332 http://www.ebi.ac.uk/interpro/entry/IPR012332 InterPro IPR013425 http://www.ebi.ac.uk/interpro/entry/IPR013425 InterPro IPR024973 http://www.ebi.ac.uk/interpro/entry/IPR024973 InterPro IPR030895 http://www.ebi.ac.uk/interpro/entry/IPR030895 KEGG_Gene ecj:JW1503 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1503 OMA GASDYTW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GASDYTW PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YDEK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDEK_ECOLI PSORT-B swissprot:YDEK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDEK_ECOLI PSORT2 swissprot:YDEK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDEK_ECOLI Pfam PF13018 http://pfam.xfam.org/family/PF13018 Phobius swissprot:YDEK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDEK_ECOLI PhylomeDB P32051 http://phylomedb.org/?seqid=P32051 ProteinModelPortal P32051 http://www.proteinmodelportal.org/query/uniprot/P32051 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8274505 http://www.ncbi.nlm.nih.gov/pubmed/8274505 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_011443591 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_011443591 STRING 316407.85674998 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85674998&targetmode=cogs SUPFAM SSF51126 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51126 TIGRFAMs TIGR02601 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02601 TIGRFAMs TIGR04393 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR04393 UniProtKB YDEK_ECOLI http://www.uniprot.org/uniprot/YDEK_ECOLI UniProtKB-AC P32051 http://www.uniprot.org/uniprot/P32051 charge swissprot:YDEK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDEK_ECOLI epestfind swissprot:YDEK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDEK_ECOLI garnier swissprot:YDEK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDEK_ECOLI helixturnhelix swissprot:YDEK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDEK_ECOLI hmoment swissprot:YDEK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDEK_ECOLI iep swissprot:YDEK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDEK_ECOLI inforesidue swissprot:YDEK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDEK_ECOLI octanol swissprot:YDEK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDEK_ECOLI pepcoil swissprot:YDEK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDEK_ECOLI pepdigest swissprot:YDEK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDEK_ECOLI pepinfo swissprot:YDEK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDEK_ECOLI pepnet swissprot:YDEK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDEK_ECOLI pepstats swissprot:YDEK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDEK_ECOLI pepwheel swissprot:YDEK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDEK_ECOLI pepwindow swissprot:YDEK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDEK_ECOLI sigcleave swissprot:YDEK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDEK_ECOLI ## Database ID URL or Descriptions # BioGrid 4259273 7 # EcoGene EG12788 yhbS # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0031248 protein acetyltransferase complex; IBA:GO_Central. # GO_function GO:0004596 peptide alpha-N-acetyltransferase activity; IBA:GO_Central. # GO_process GO:0006474 N-terminal protein amino acid acetylation; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0006464 cellular protein modification process # Gene3D 3.40.630.30 -; 1. # IntAct P63417 7 # InterPro IPR000182 GNAT_dom # InterPro IPR016181 Acyl_CoA_acyltransferase # KEGG_Brite ko01000 Enzymes # Organism YHBS_ECOLI Escherichia coli (strain K12) # PATRIC 32121730 VBIEscCol129921_3251 # PIR H65105 H65105 # PROSITE PS51186 GNAT # Pfam PF13508 Acetyltransf_7 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHBS_ECOLI Uncharacterized N-acetyltransferase YhbS # RefSeq NP_417625 NC_000913.3 # RefSeq WP_000908554 NZ_LN832404.1 # SIMILARITY Belongs to the acetyltransferase family. {ECO 0000305}. # SIMILARITY Contains 1 N-acetyltransferase domain. {ECO:0000255|PROSITE-ProRule PRU00532}. # SUPFAM SSF55729 SSF55729 # eggNOG COG3153 LUCA # eggNOG ENOG4108YYD Bacteria BLAST swissprot:YHBS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHBS_ECOLI BioCyc ECOL316407:JW3125-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3125-MONOMER BioCyc EcoCyc:G7650-MONOMER http://biocyc.org/getid?id=EcoCyc:G7650-MONOMER COG COG3153 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3153 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 2.3.1.- http://enzyme.expasy.org/EC/2.3.1.- EchoBASE EB2640 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2640 EcoGene EG12788 http://www.ecogene.org/geneInfo.php?eg_id=EG12788 EnsemblBacteria AAC76190 http://www.ensemblgenomes.org/id/AAC76190 EnsemblBacteria AAC76190 http://www.ensemblgenomes.org/id/AAC76190 EnsemblBacteria BAE77202 http://www.ensemblgenomes.org/id/BAE77202 EnsemblBacteria BAE77202 http://www.ensemblgenomes.org/id/BAE77202 EnsemblBacteria BAE77202 http://www.ensemblgenomes.org/id/BAE77202 EnsemblBacteria b3156 http://www.ensemblgenomes.org/id/b3156 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0031248 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031248 GO_function GO:0004596 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004596 GO_process GO:0006474 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006474 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 Gene3D 3.40.630.30 http://www.cathdb.info/version/latest/superfamily/3.40.630.30 GeneID 947670 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947670 HOGENOM HOG000031671 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000031671&db=HOGENOM6 InParanoid P63417 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P63417 IntAct P63417 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P63417* IntEnz 2.3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1 InterPro IPR000182 http://www.ebi.ac.uk/interpro/entry/IPR000182 InterPro IPR016181 http://www.ebi.ac.uk/interpro/entry/IPR016181 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3125 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3125 KEGG_Gene eco:b3156 http://www.genome.jp/dbget-bin/www_bget?eco:b3156 KEGG_Orthology KO:K03824 http://www.genome.jp/dbget-bin/www_bget?KO:K03824 OMA DEDIVGH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DEDIVGH PROSITE PS51186 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51186 PSORT swissprot:YHBS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHBS_ECOLI PSORT-B swissprot:YHBS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHBS_ECOLI PSORT2 swissprot:YHBS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHBS_ECOLI Pfam PF13508 http://pfam.xfam.org/family/PF13508 Phobius swissprot:YHBS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHBS_ECOLI PhylomeDB P63417 http://phylomedb.org/?seqid=P63417 ProteinModelPortal P63417 http://www.proteinmodelportal.org/query/uniprot/P63417 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417625 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417625 RefSeq WP_000908554 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000908554 SMR P63417 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P63417 STRING 511145.b3156 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3156&targetmode=cogs STRING COG3153 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3153&targetmode=cogs SUPFAM SSF55729 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55729 UniProtKB YHBS_ECOLI http://www.uniprot.org/uniprot/YHBS_ECOLI UniProtKB-AC P63417 http://www.uniprot.org/uniprot/P63417 charge swissprot:YHBS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHBS_ECOLI eggNOG COG3153 http://eggnogapi.embl.de/nog_data/html/tree/COG3153 eggNOG ENOG4108YYD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108YYD epestfind swissprot:YHBS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHBS_ECOLI garnier swissprot:YHBS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHBS_ECOLI helixturnhelix swissprot:YHBS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHBS_ECOLI hmoment swissprot:YHBS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHBS_ECOLI iep swissprot:YHBS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHBS_ECOLI inforesidue swissprot:YHBS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHBS_ECOLI octanol swissprot:YHBS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHBS_ECOLI pepcoil swissprot:YHBS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHBS_ECOLI pepdigest swissprot:YHBS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHBS_ECOLI pepinfo swissprot:YHBS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHBS_ECOLI pepnet swissprot:YHBS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHBS_ECOLI pepstats swissprot:YHBS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHBS_ECOLI pepwheel swissprot:YHBS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHBS_ECOLI pepwindow swissprot:YHBS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHBS_ECOLI sigcleave swissprot:YHBS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHBS_ECOLI ## Database ID URL or Descriptions # AltName GTP-binding protein HflX {ECO:0000255|HAMAP-Rule MF_00900} # BioGrid 4261252 360 # CDD cd01878 HflX # COFACTOR HFLX_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_00900}; # DISRUPTION PHENOTYPE Disruption does not affect lambda lysogeny or the transposition frequency of transposable elements. {ECO:0000269|PubMed 19181811}. # DOMAIN HFLX_ECOLI Full-length protein is required for specific association with the 50S ribosomal subunit. {ECO 0000269|PubMed 19109926}. # ENZYME REGULATION HFLX_ECOLI Intrinsic GTPase activity is very slow and can be stimulated by the presence of 50S ribosomal subunits or 70S ribosomes. GTPase activity is inhibited by ATP. {ECO 0000269|PubMed 19109926, ECO 0000269|PubMed 19181811, ECO 0000269|PubMed 19824612}. # EcoGene EG10437 hflX # FUNCTION HFLX_ECOLI GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. In vitro, also exhibits ATPase activity. {ECO 0000255|HAMAP-Rule MF_00900, ECO 0000269|PubMed 19109926, ECO 0000269|PubMed 19181811, ECO 0000269|PubMed 19824612}. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0003924 GTPase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0005524 ATP binding; IDA:EcoliWiki. # GO_function GO:0005525 GTP binding; IDA:EcoCyc. # GO_function GO:0019843 rRNA binding; IDA:EcoCyc. # GO_function GO:0043022 ribosome binding; IDA:EcoCyc. # GO_process GO:0009408 response to heat; IEP:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003924 GTPase activity # GOslim_function GO:0019843 rRNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # Gene3D 3.40.50.300 -; 1. # HAMAP MF_00900 GTPase_HflX # InterPro IPR006073 GTP_binding_domain # InterPro IPR009022 EFG_III-V # InterPro IPR016496 GTPase_HflX # InterPro IPR025121 GTPase_HflX_N # InterPro IPR027417 P-loop_NTPase # InterPro IPR030394 G_HFLX_dom # InterPro IPR032305 GTP-bd_M # Organism HFLX_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10229 PTHR10229 # PATRIC 32123919 VBIEscCol129921_4304 # PDB 5ADY EM; 4.50 A; 6=1-426 # PIR S56398 S56398 # PIRSF PIRSF006809 GTP-binding_hflX_prd # PRINTS PR00326 GTP1OBG # PROSITE PS51705 G_HFLX # Pfam PF01926 MMR_HSR1 # Pfam PF13167 GTP-bdg_N # Pfam PF16360 GTP-bdg_M # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GTPase HflX {ECO:0000255|HAMAP-Rule MF_00900} # RefSeq NP_418594 NC_000913.3 # RefSeq WP_000460362 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA00645.1; Type=Frameshift; Positions=18; Evidence={ECO 0000305}; # SIMILARITY Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. {ECO:0000255|HAMAP- Rule MF_00900}. # SIMILARITY Contains 1 Hflx-type G (guanine nucleotide-binding) domain. {ECO:0000255|HAMAP-Rule MF_00900}. # SUBCELLULAR LOCATION HFLX_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00900, ECO 0000269|PubMed 19181811}. Note=May associate with membranes. # SUBUNIT HFLX_ECOLI Monomer. Associates with the 50S ribosomal subunit. This interaction occurs in the presence of GTP, GDP, ATP or ADP, but not in their absence. {ECO 0000255|HAMAP-Rule MF_00900, ECO 0000269|PubMed 19109926, ECO 0000269|PubMed 19181811}. # SUPFAM SSF52540 SSF52540 # SUPFAM SSF54980 SSF54980 # TIGRFAMs TIGR03156 GTP_HflX # eggNOG COG2262 LUCA # eggNOG ENOG4105C1N Bacteria BLAST swissprot:HFLX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HFLX_ECOLI BioCyc ECOL316407:JW4131-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4131-MONOMER BioCyc EcoCyc:EG10437-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10437-MONOMER BioCyc MetaCyc:EG10437-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10437-MONOMER COG COG2262 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2262 DIP DIP-9895N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9895N DOI 10.1016/j.bbrc.2008.12.072 http://dx.doi.org/10.1016/j.bbrc.2008.12.072 DOI 10.1021/bi901074h http://dx.doi.org/10.1021/bi901074h DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.90.22.10866 http://dx.doi.org/10.1073/pnas.90.22.10866 DOI 10.1093/nar/19.5.1063 http://dx.doi.org/10.1093/nar/19.5.1063 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01353-08 http://dx.doi.org/10.1128/JB.01353-08 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D00743 http://www.ebi.ac.uk/ena/data/view/D00743 EMBL U00005 http://www.ebi.ac.uk/ena/data/view/U00005 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB0432 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0432 EcoGene EG10437 http://www.ecogene.org/geneInfo.php?eg_id=EG10437 EnsemblBacteria AAC77130 http://www.ensemblgenomes.org/id/AAC77130 EnsemblBacteria AAC77130 http://www.ensemblgenomes.org/id/AAC77130 EnsemblBacteria BAE78174 http://www.ensemblgenomes.org/id/BAE78174 EnsemblBacteria BAE78174 http://www.ensemblgenomes.org/id/BAE78174 EnsemblBacteria BAE78174 http://www.ensemblgenomes.org/id/BAE78174 EnsemblBacteria b4173 http://www.ensemblgenomes.org/id/b4173 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GO_function GO:0043022 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043022 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948688 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948688 HAMAP MF_00900 http://hamap.expasy.org/unirule/MF_00900 HOGENOM HOG000260368 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260368&db=HOGENOM6 InParanoid P25519 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P25519 IntAct P25519 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P25519* InterPro IPR006073 http://www.ebi.ac.uk/interpro/entry/IPR006073 InterPro IPR009022 http://www.ebi.ac.uk/interpro/entry/IPR009022 InterPro IPR016496 http://www.ebi.ac.uk/interpro/entry/IPR016496 InterPro IPR025121 http://www.ebi.ac.uk/interpro/entry/IPR025121 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR030394 http://www.ebi.ac.uk/interpro/entry/IPR030394 InterPro IPR032305 http://www.ebi.ac.uk/interpro/entry/IPR032305 KEGG_Gene ecj:JW4131 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4131 KEGG_Gene eco:b4173 http://www.genome.jp/dbget-bin/www_bget?eco:b4173 KEGG_Orthology KO:K03665 http://www.genome.jp/dbget-bin/www_bget?KO:K03665 OMA AVLVHIN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AVLVHIN PANTHER PTHR10229 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10229 PDB 5ADY http://www.ebi.ac.uk/pdbe-srv/view/entry/5ADY PDBsum 5ADY http://www.ebi.ac.uk/pdbsum/5ADY PRINTS PR00326 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00326 PROSITE PS51705 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51705 PSORT swissprot:HFLX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HFLX_ECOLI PSORT-B swissprot:HFLX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HFLX_ECOLI PSORT2 swissprot:HFLX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HFLX_ECOLI Pfam PF01926 http://pfam.xfam.org/family/PF01926 Pfam PF13167 http://pfam.xfam.org/family/PF13167 Pfam PF16360 http://pfam.xfam.org/family/PF16360 Phobius swissprot:HFLX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HFLX_ECOLI PhylomeDB P25519 http://phylomedb.org/?seqid=P25519 ProteinModelPortal P25519 http://www.proteinmodelportal.org/query/uniprot/P25519 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19109926 http://www.ncbi.nlm.nih.gov/pubmed/19109926 PubMed 19181811 http://www.ncbi.nlm.nih.gov/pubmed/19181811 PubMed 19824612 http://www.ncbi.nlm.nih.gov/pubmed/19824612 PubMed 2020545 http://www.ncbi.nlm.nih.gov/pubmed/2020545 PubMed 3040675 http://www.ncbi.nlm.nih.gov/pubmed/3040675 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8248183 http://www.ncbi.nlm.nih.gov/pubmed/8248183 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418594 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418594 RefSeq WP_000460362 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000460362 SMR P25519 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P25519 STRING 511145.b4173 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4173&targetmode=cogs STRING COG2262 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2262&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SUPFAM SSF54980 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54980 TIGRFAMs TIGR03156 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03156 UniProtKB HFLX_ECOLI http://www.uniprot.org/uniprot/HFLX_ECOLI UniProtKB-AC P25519 http://www.uniprot.org/uniprot/P25519 charge swissprot:HFLX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HFLX_ECOLI eggNOG COG2262 http://eggnogapi.embl.de/nog_data/html/tree/COG2262 eggNOG ENOG4105C1N http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C1N epestfind swissprot:HFLX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HFLX_ECOLI garnier swissprot:HFLX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HFLX_ECOLI helixturnhelix swissprot:HFLX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HFLX_ECOLI hmoment swissprot:HFLX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HFLX_ECOLI iep swissprot:HFLX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HFLX_ECOLI inforesidue swissprot:HFLX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HFLX_ECOLI octanol swissprot:HFLX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HFLX_ECOLI pepcoil swissprot:HFLX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HFLX_ECOLI pepdigest swissprot:HFLX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HFLX_ECOLI pepinfo swissprot:HFLX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HFLX_ECOLI pepnet swissprot:HFLX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HFLX_ECOLI pepstats swissprot:HFLX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HFLX_ECOLI pepwheel swissprot:HFLX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HFLX_ECOLI pepwindow swissprot:HFLX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HFLX_ECOLI sigcleave swissprot:HFLX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HFLX_ECOLI ## Database ID URL or Descriptions # BioGrid 4260029 4 # EcoGene EG13719 ymbA # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GOslim_component GO:0005886 plasma membrane # Gene3D 3.40.50.10610 -; 1. # IntAct P0AB10 4 # InterPro IPR005586 ABC_trans_aux # Organism YMBA_ECOLI Escherichia coli (strain K12) # PATRIC 32117123 VBIEscCol129921_0986 # PIR G64835 G64835 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF03886 ABC_trans_aux # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YMBA_ECOLI Uncharacterized lipoprotein YmbA # RefSeq NP_415472 NC_000913.3 # RefSeq WP_000759120 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA35710.2; Type=Erroneous initiation; Evidence={ECO 0000305}; # SUBCELLULAR LOCATION YMBA_ECOLI Cell membrane {ECO 0000255|PROSITE- ProRule PRU00303}; Lipid-anchor {ECO 0000255|PROSITE- ProRule PRU00303}. # eggNOG COG3009 LUCA # eggNOG ENOG4108Q2G Bacteria BLAST swissprot:YMBA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YMBA_ECOLI BioCyc ECOL316407:JW5127-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5127-MONOMER BioCyc EcoCyc:G6492-MONOMER http://biocyc.org/getid?id=EcoCyc:G6492-MONOMER COG COG3009 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3009 DIP DIP-48221N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48221N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3483 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3483 EcoGene EG13719 http://www.ecogene.org/geneInfo.php?eg_id=EG13719 EnsemblBacteria AAC74038 http://www.ensemblgenomes.org/id/AAC74038 EnsemblBacteria AAC74038 http://www.ensemblgenomes.org/id/AAC74038 EnsemblBacteria BAA35710 http://www.ensemblgenomes.org/id/BAA35710 EnsemblBacteria BAA35710 http://www.ensemblgenomes.org/id/BAA35710 EnsemblBacteria BAA35710 http://www.ensemblgenomes.org/id/BAA35710 EnsemblBacteria b0952 http://www.ensemblgenomes.org/id/b0952 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 Gene3D 3.40.50.10610 http://www.cathdb.info/version/latest/superfamily/3.40.50.10610 GeneID 946972 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946972 HOGENOM HOG000283606 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000283606&db=HOGENOM6 IntAct P0AB10 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AB10* InterPro IPR005586 http://www.ebi.ac.uk/interpro/entry/IPR005586 KEGG_Gene ecj:JW5127 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5127 KEGG_Gene eco:b0952 http://www.genome.jp/dbget-bin/www_bget?eco:b0952 KEGG_Orthology KO:K09857 http://www.genome.jp/dbget-bin/www_bget?KO:K09857 OMA GWAQESA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GWAQESA PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YMBA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YMBA_ECOLI PSORT-B swissprot:YMBA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YMBA_ECOLI PSORT2 swissprot:YMBA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YMBA_ECOLI Pfam PF03886 http://pfam.xfam.org/family/PF03886 Phobius swissprot:YMBA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YMBA_ECOLI ProteinModelPortal P0AB10 http://www.proteinmodelportal.org/query/uniprot/P0AB10 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415472 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415472 RefSeq WP_000759120 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000759120 SMR P0AB10 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AB10 STRING 511145.b0952 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0952&targetmode=cogs STRING COG3009 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3009&targetmode=cogs UniProtKB YMBA_ECOLI http://www.uniprot.org/uniprot/YMBA_ECOLI UniProtKB-AC P0AB10 http://www.uniprot.org/uniprot/P0AB10 charge swissprot:YMBA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YMBA_ECOLI eggNOG COG3009 http://eggnogapi.embl.de/nog_data/html/tree/COG3009 eggNOG ENOG4108Q2G http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Q2G epestfind swissprot:YMBA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YMBA_ECOLI garnier swissprot:YMBA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YMBA_ECOLI helixturnhelix swissprot:YMBA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YMBA_ECOLI hmoment swissprot:YMBA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YMBA_ECOLI iep swissprot:YMBA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YMBA_ECOLI inforesidue swissprot:YMBA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YMBA_ECOLI octanol swissprot:YMBA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YMBA_ECOLI pepcoil swissprot:YMBA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YMBA_ECOLI pepdigest swissprot:YMBA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YMBA_ECOLI pepinfo swissprot:YMBA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YMBA_ECOLI pepnet swissprot:YMBA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YMBA_ECOLI pepstats swissprot:YMBA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YMBA_ECOLI pepwheel swissprot:YMBA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YMBA_ECOLI pepwindow swissprot:YMBA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YMBA_ECOLI sigcleave swissprot:YMBA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YMBA_ECOLI ## Database ID URL or Descriptions # AltName ACRA_ECOLI AcrAB-TolC multidrug efflux pump subunit AcrA # AltName ACRA_ECOLI Acridine resistance protein A # BioGrid 4259860 387 # DISRUPTION PHENOTYPE Cannot grow on efflux substrates novobiocin or fusidic acid. {ECO:0000269|PubMed 9878415}. # EcoGene EG11703 acrA # FUNCTION ACRA_ECOLI AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. This subunit may act as an adapter protein that links AcrB and TolC stably together. It is elongated in shape, being long enough to span the periplasm. {ECO 0000269|PubMed 9878415}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_component GO:0031226 intrinsic component of plasma membrane; IBA:GO_Central. # GO_function GO:0015238 drug transmembrane transporter activity; IMP:EcoliWiki. # GO_process GO:0006855 drug transmembrane transport; IMP:EcoCyc. # GO_process GO:0015721 bile acid and bile salt transport; IMP:EcoCyc. # GO_process GO:0046677 response to antibiotic; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # GOslim_process GO:0055085 transmembrane transport # INTERACTION ACRA_ECOLI Self; NbExp=3; IntAct=EBI-875601, EBI-875601; # IntAct P0AE06 5 # InterPro IPR006143 RND_pump_MFP # InterPro IPR032317 HlyD_D23 # KEGG_Brite ko03036 Chromosome # Organism ACRA_ECOLI Escherichia coli (strain K12) # PATRIC 32116079 VBIEscCol129921_0481 # PDB 2F1M X-ray; 2.71 A; A/B/C/D=45-312 # PIR A36938 A36938 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF00529 HlyD # Pfam PF16576 HlyD_D23 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ACRA_ECOLI Multidrug efflux pump subunit AcrA # RefSeq NP_414996 NC_000913.3 # RefSeq WP_001295324 NZ_LN832404.1 # SIMILARITY Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. {ECO 0000305}. # SUBCELLULAR LOCATION ACRA_ECOLI Cell inner membrane {ECO 0000269|PubMed 15228545, ECO 0000269|PubMed 16079137}; Lipid- anchor {ECO 0000255|PROSITE-ProRule PRU00303, ECO 0000269|PubMed 15228545, ECO 0000269|PubMed 16079137}. Note=An unlipidated version of this protein (directed to the periplasm by the OmpA signal sequence) functions normally. # SUBUNIT ACRA_ECOLI Monomeric in solution. Homotrimeric; interacts indpendently with AcrB and TolC as well as AcrZ. Part of the AcrA- AcrB-TolC efflux pump. Complex assembly is independent of an efflux substrate and appears to be constitutive. {ECO 0000269|PubMed 10920254, ECO 0000269|PubMed 15228545, ECO 0000269|PubMed 23010927, ECO 0000269|PubMed 9878415}. # TCDB 8.A.1.6 the membrane fusion protein (mfp) family # TIGRFAMs TIGR01730 RND_mfp # eggNOG ENOG4105C1P Bacteria # eggNOG ENOG410XNVN LUCA BLAST swissprot:ACRA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ACRA_ECOLI BioCyc ECOL316407:JW0452-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0452-MONOMER BioCyc EcoCyc:EG11703-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11703-MONOMER COG COG0845 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0845 DIP DIP-29039N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-29039N DOI 10.1006/jmbi.1998.2313 http://dx.doi.org/10.1006/jmbi.1998.2313 DOI 10.1016/j.str.2005.11.015 http://dx.doi.org/10.1016/j.str.2005.11.015 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.1210093109 http://dx.doi.org/10.1073/pnas.1210093109 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1093/oxfordjournals.jbchem.a022741 http://dx.doi.org/10.1093/oxfordjournals.jbchem.a022741 DOI 10.1111/j.1365-2958.1995.tb02390.x http://dx.doi.org/10.1111/j.1365-2958.1995.tb02390.x DOI 10.1111/j.1365-2958.2004.04158.x http://dx.doi.org/10.1111/j.1365-2958.2004.04158.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M94248 http://www.ebi.ac.uk/ena/data/view/M94248 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U00734 http://www.ebi.ac.uk/ena/data/view/U00734 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EchoBASE EB1654 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1654 EcoGene EG11703 http://www.ecogene.org/geneInfo.php?eg_id=EG11703 EnsemblBacteria AAC73565 http://www.ensemblgenomes.org/id/AAC73565 EnsemblBacteria AAC73565 http://www.ensemblgenomes.org/id/AAC73565 EnsemblBacteria BAE76242 http://www.ensemblgenomes.org/id/BAE76242 EnsemblBacteria BAE76242 http://www.ensemblgenomes.org/id/BAE76242 EnsemblBacteria BAE76242 http://www.ensemblgenomes.org/id/BAE76242 EnsemblBacteria b0463 http://www.ensemblgenomes.org/id/b0463 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_component GO:0031226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031226 GO_function GO:0015238 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015238 GO_process GO:0006855 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006855 GO_process GO:0015721 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015721 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 945112 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945112 HOGENOM HOG000158247 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000158247&db=HOGENOM6 InParanoid P0AE06 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AE06 IntAct P0AE06 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AE06* InterPro IPR006143 http://www.ebi.ac.uk/interpro/entry/IPR006143 InterPro IPR032317 http://www.ebi.ac.uk/interpro/entry/IPR032317 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene ecj:JW0452 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0452 KEGG_Gene eco:b0463 http://www.genome.jp/dbget-bin/www_bget?eco:b0463 KEGG_Orthology KO:K03585 http://www.genome.jp/dbget-bin/www_bget?KO:K03585 OMA NKNRRLT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NKNRRLT PDB 2F1M http://www.ebi.ac.uk/pdbe-srv/view/entry/2F1M PDBsum 2F1M http://www.ebi.ac.uk/pdbsum/2F1M PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:ACRA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ACRA_ECOLI PSORT-B swissprot:ACRA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ACRA_ECOLI PSORT2 swissprot:ACRA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ACRA_ECOLI Pfam PF00529 http://pfam.xfam.org/family/PF00529 Pfam PF16576 http://pfam.xfam.org/family/PF16576 Phobius swissprot:ACRA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ACRA_ECOLI PhylomeDB P0AE06 http://phylomedb.org/?seqid=P0AE06 ProteinModelPortal P0AE06 http://www.proteinmodelportal.org/query/uniprot/P0AE06 PubMed 10920254 http://www.ncbi.nlm.nih.gov/pubmed/10920254 PubMed 15228545 http://www.ncbi.nlm.nih.gov/pubmed/15228545 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16531241 http://www.ncbi.nlm.nih.gov/pubmed/16531241 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 23010927 http://www.ncbi.nlm.nih.gov/pubmed/23010927 PubMed 7651136 http://www.ncbi.nlm.nih.gov/pubmed/7651136 PubMed 8407802 http://www.ncbi.nlm.nih.gov/pubmed/8407802 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9878415 http://www.ncbi.nlm.nih.gov/pubmed/9878415 RefSeq NP_414996 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414996 RefSeq WP_001295324 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295324 SMR P0AE06 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AE06 STRING 511145.b0463 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0463&targetmode=cogs STRING COG0845 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0845&targetmode=cogs TCDB 8.A.1.6 http://www.tcdb.org/search/result.php?tc=8.A.1.6 TIGRFAMs TIGR01730 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01730 UniProtKB ACRA_ECOLI http://www.uniprot.org/uniprot/ACRA_ECOLI UniProtKB-AC P0AE06 http://www.uniprot.org/uniprot/P0AE06 charge swissprot:ACRA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ACRA_ECOLI eggNOG ENOG4105C1P http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C1P eggNOG ENOG410XNVN http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNVN epestfind swissprot:ACRA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ACRA_ECOLI garnier swissprot:ACRA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ACRA_ECOLI helixturnhelix swissprot:ACRA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ACRA_ECOLI hmoment swissprot:ACRA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ACRA_ECOLI iep swissprot:ACRA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ACRA_ECOLI inforesidue swissprot:ACRA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ACRA_ECOLI octanol swissprot:ACRA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ACRA_ECOLI pepcoil swissprot:ACRA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ACRA_ECOLI pepdigest swissprot:ACRA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ACRA_ECOLI pepinfo swissprot:ACRA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ACRA_ECOLI pepnet swissprot:ACRA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ACRA_ECOLI pepstats swissprot:ACRA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ACRA_ECOLI pepwheel swissprot:ACRA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ACRA_ECOLI pepwindow swissprot:ACRA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ACRA_ECOLI sigcleave swissprot:ACRA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ACRA_ECOLI ## Database ID URL or Descriptions # AltName Hydroxymethylpyrimidine phosphate synthase {ECO:0000255|HAMAP-Rule MF_00089} # AltName Thiamine biosynthesis protein ThiC {ECO:0000255|HAMAP-Rule MF_00089} # BioGrid 4259335 8 # CATALYTIC ACTIVITY 5-amino-1-(5-phospho-D-ribosyl)imidazole + S- adenosyl-L-methionine = 4-amino-2-methyl-5- (phosphomethyl)pyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO. {ECO:0000255|HAMAP-Rule MF_00089}. # COFACTOR THIC_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000255|HAMAP-Rule MF_00089}; Note=Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L- methionine. {ECO 0000255|HAMAP-Rule MF_00089}; # EcoGene EG11585 thiC # FUNCTION THIC_ECOLI Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. {ECO 0000305|PubMed 15292217, ECO 0000305|PubMed 15326535}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0016829 lyase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0009228 thiamine biosynthetic process; IDA:EcoCyc. # GO_process GO:0009229 thiamine diphosphate biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # HAMAP MF_00089 ThiC # IntAct P30136 7 # InterPro IPR002817 ThiC # InterPro IPR025747 ThiC-associated_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Pathway ko00730 Thiamine metabolism # Organism THIC_ECOLI Escherichia coli (strain K12) # PATHWAY Cofactor biosynthesis; thiamine diphosphate biosynthesis. {ECO:0000255|HAMAP-Rule MF_00089}. # PATRIC 32123511 VBIEscCol129921_4108 # PIR E65206 E65206 # Pfam PF01964 ThiC_Rad_SAM # Pfam PF13667 ThiC-associated # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Phosphomethylpyrimidine synthase {ECO:0000255|HAMAP-Rule MF_00089} # RefSeq NP_418422 NC_000913.3 # RefSeq WP_001276926 NZ_LN832404.1 # SIMILARITY Belongs to the ThiC family. {ECO:0000255|HAMAP- Rule MF_00089}. # SUBUNIT Homodimer. {ECO:0000255|HAMAP-Rule MF_00089}. # TIGRFAMs TIGR00190 thiC # eggNOG COG0422 LUCA # eggNOG ENOG4105CBF Bacteria BLAST swissprot:THIC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:THIC_ECOLI BioCyc ECOL316407:JW3958-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3958-MONOMER BioCyc EcoCyc:THIC-MONOMER http://biocyc.org/getid?id=EcoCyc:THIC-MONOMER BioCyc MetaCyc:THIC-MONOMER http://biocyc.org/getid?id=MetaCyc:THIC-MONOMER COG COG0422 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0422 DIP DIP-10982N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10982N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1039/b405429f http://dx.doi.org/10.1039/b405429f DOI 10.1074/jbc.M404284200 http://dx.doi.org/10.1074/jbc.M404284200 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.1.99.17 {ECO:0000255|HAMAP-Rule:MF_00089} http://www.genome.jp/dbget-bin/www_bget?EC:4.1.99.17 {ECO:0000255|HAMAP-Rule:MF_00089} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M88701 http://www.ebi.ac.uk/ena/data/view/M88701 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 4.1.99.17 {ECO:0000255|HAMAP-Rule:MF_00089} http://enzyme.expasy.org/EC/4.1.99.17 {ECO:0000255|HAMAP-Rule:MF_00089} EchoBASE EB1544 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1544 EcoGene EG11585 http://www.ecogene.org/geneInfo.php?eg_id=EG11585 EnsemblBacteria AAC76968 http://www.ensemblgenomes.org/id/AAC76968 EnsemblBacteria AAC76968 http://www.ensemblgenomes.org/id/AAC76968 EnsemblBacteria BAE77325 http://www.ensemblgenomes.org/id/BAE77325 EnsemblBacteria BAE77325 http://www.ensemblgenomes.org/id/BAE77325 EnsemblBacteria BAE77325 http://www.ensemblgenomes.org/id/BAE77325 EnsemblBacteria b3994 http://www.ensemblgenomes.org/id/b3994 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0009228 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009228 GO_process GO:0009229 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009229 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GeneID 948492 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948492 HAMAP MF_00089 http://hamap.expasy.org/unirule/MF_00089 HOGENOM HOG000224484 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000224484&db=HOGENOM6 InParanoid P30136 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30136 IntAct P30136 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P30136* IntEnz 4.1.99.17 {ECO:0000255|HAMAP-Rule:MF_00089} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.99.17 {ECO:0000255|HAMAP-Rule:MF_00089} InterPro IPR002817 http://www.ebi.ac.uk/interpro/entry/IPR002817 InterPro IPR025747 http://www.ebi.ac.uk/interpro/entry/IPR025747 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Gene ecj:JW3958 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3958 KEGG_Gene eco:b3994 http://www.genome.jp/dbget-bin/www_bget?eco:b3994 KEGG_Orthology KO:K03147 http://www.genome.jp/dbget-bin/www_bget?KO:K03147 KEGG_Pathway ko00730 http://www.genome.jp/kegg-bin/show_pathway?ko00730 KEGG_Reaction rn:R03472 http://www.genome.jp/dbget-bin/www_bget?rn:R03472 OMA TWELFRD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TWELFRD PSORT swissprot:THIC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:THIC_ECOLI PSORT-B swissprot:THIC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:THIC_ECOLI PSORT2 swissprot:THIC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:THIC_ECOLI Pfam PF01964 http://pfam.xfam.org/family/PF01964 Pfam PF13667 http://pfam.xfam.org/family/PF13667 Phobius swissprot:THIC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:THIC_ECOLI PhylomeDB P30136 http://phylomedb.org/?seqid=P30136 ProteinModelPortal P30136 http://www.proteinmodelportal.org/query/uniprot/P30136 PubMed 15292217 http://www.ncbi.nlm.nih.gov/pubmed/15292217 PubMed 15326535 http://www.ncbi.nlm.nih.gov/pubmed/15326535 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 8432721 http://www.ncbi.nlm.nih.gov/pubmed/8432721 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418422 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418422 RefSeq WP_001276926 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001276926 SMR P30136 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P30136 STRING 511145.b3994 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3994&targetmode=cogs STRING COG0422 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0422&targetmode=cogs TIGRFAMs TIGR00190 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00190 UniProtKB THIC_ECOLI http://www.uniprot.org/uniprot/THIC_ECOLI UniProtKB-AC P30136 http://www.uniprot.org/uniprot/P30136 charge swissprot:THIC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:THIC_ECOLI eggNOG COG0422 http://eggnogapi.embl.de/nog_data/html/tree/COG0422 eggNOG ENOG4105CBF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CBF epestfind swissprot:THIC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:THIC_ECOLI garnier swissprot:THIC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:THIC_ECOLI helixturnhelix swissprot:THIC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:THIC_ECOLI hmoment swissprot:THIC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:THIC_ECOLI iep swissprot:THIC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:THIC_ECOLI inforesidue swissprot:THIC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:THIC_ECOLI octanol swissprot:THIC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:THIC_ECOLI pepcoil swissprot:THIC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:THIC_ECOLI pepdigest swissprot:THIC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:THIC_ECOLI pepinfo swissprot:THIC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:THIC_ECOLI pepnet swissprot:THIC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:THIC_ECOLI pepstats swissprot:THIC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:THIC_ECOLI pepwheel swissprot:THIC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:THIC_ECOLI pepwindow swissprot:THIC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:THIC_ECOLI sigcleave swissprot:THIC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:THIC_ECOLI ## Database ID URL or Descriptions # BioGrid 4262477 13 # EcoGene EG10654 nirC # FUNCTION NIRC_ECOLI Catalyzes nitrite uptake and nitrite export across the cytoplasmic membrane. Is up to 10-fold more active than NarK or NarU in nitrite uptake for subsequent reduction in the cytoplasm by the NirB/NirD nitrite reductase. {ECO 0000269|PubMed 11967075, ECO 0000269|PubMed 15667293, ECO 0000269|PubMed 18691156}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_component GO:0016021 integral component of membrane; ISM:CACAO. # GO_function GO:0005215 transporter activity; IEA:InterPro. # GO_process GO:0042128 nitrate assimilation; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0071941 nitrogen cycle metabolic process # Gene3D 1.20.1080.10 -; 1. # InterPro IPR000292 For/NO2_transpt # InterPro IPR023271 Aquaporin-like # InterPro IPR024002 For/NO2_transpt_CS # KEGG_Brite ko02000 Transporters # Organism NIRC_ECOLI Escherichia coli (strain K12) # PATRIC 32122168 VBIEscCol129921_3461 # PIR B65131 B65131 # PROSITE PS01005 FORMATE_NITRITE_TP_1 # PROSITE PS01006 FORMATE_NITRITE_TP_2 # Pfam PF01226 Form_Nir_trans # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NIRC_ECOLI Nitrite transporter NirC # RefSeq WP_000493556 NZ_CP014272.1 # RefSeq YP_026212 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA58164.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA32418.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the FNT transporter (TC 2.A.44) family. {ECO 0000305}. # SUBCELLULAR LOCATION NIRC_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # TCDB 1.A.16.3 the formate-nitrite transporter (fnt) family # TIGRFAMs TIGR00790 fnt # eggNOG COG2116 LUCA # eggNOG ENOG4107V9H Bacteria BLAST swissprot:NIRC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NIRC_ECOLI BioCyc ECOL316407:JW3330-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3330-MONOMER BioCyc EcoCyc:NIRC-MONOMER http://biocyc.org/getid?id=EcoCyc:NIRC-MONOMER BioCyc MetaCyc:NIRC-MONOMER http://biocyc.org/getid?id=MetaCyc:NIRC-MONOMER COG COG2116 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2116 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/BJ20080746 http://dx.doi.org/10.1042/BJ20080746 DOI 10.1042/BST0330159 http://dx.doi.org/10.1042/BST0330159 DOI 10.1046/j.1365-2958.2002.02858.x http://dx.doi.org/10.1046/j.1365-2958.2002.02858.x DOI 10.1093/nar/17.10.3865 http://dx.doi.org/10.1093/nar/17.10.3865 DOI 10.1111/j.1432-1033.1990.tb19125.x http://dx.doi.org/10.1111/j.1432-1033.1990.tb19125.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X14202 http://www.ebi.ac.uk/ena/data/view/X14202 EchoBASE EB0648 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0648 EcoGene EG10654 http://www.ecogene.org/geneInfo.php?eg_id=EG10654 EnsemblBacteria AAC76392 http://www.ensemblgenomes.org/id/AAC76392 EnsemblBacteria AAC76392 http://www.ensemblgenomes.org/id/AAC76392 EnsemblBacteria BAE77923 http://www.ensemblgenomes.org/id/BAE77923 EnsemblBacteria BAE77923 http://www.ensemblgenomes.org/id/BAE77923 EnsemblBacteria BAE77923 http://www.ensemblgenomes.org/id/BAE77923 EnsemblBacteria b3367 http://www.ensemblgenomes.org/id/b3367 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_process GO:0042128 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042128 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0071941 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071941 Gene3D 1.20.1080.10 http://www.cathdb.info/version/latest/superfamily/1.20.1080.10 GeneID 2847757 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2847757 HOGENOM HOG000271392 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000271392&db=HOGENOM6 InParanoid P0AC26 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AC26 InterPro IPR000292 http://www.ebi.ac.uk/interpro/entry/IPR000292 InterPro IPR023271 http://www.ebi.ac.uk/interpro/entry/IPR023271 InterPro IPR024002 http://www.ebi.ac.uk/interpro/entry/IPR024002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3330 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3330 KEGG_Gene eco:b3367 http://www.genome.jp/dbget-bin/www_bget?eco:b3367 KEGG_Orthology KO:K02598 http://www.genome.jp/dbget-bin/www_bget?KO:K02598 OMA KYAHVMT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KYAHVMT PROSITE PS01005 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01005 PROSITE PS01006 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01006 PSORT swissprot:NIRC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NIRC_ECOLI PSORT-B swissprot:NIRC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NIRC_ECOLI PSORT2 swissprot:NIRC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NIRC_ECOLI Pfam PF01226 http://pfam.xfam.org/family/PF01226 Phobius swissprot:NIRC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NIRC_ECOLI PhylomeDB P0AC26 http://phylomedb.org/?seqid=P0AC26 ProteinModelPortal P0AC26 http://www.proteinmodelportal.org/query/uniprot/P0AC26 PubMed 11967075 http://www.ncbi.nlm.nih.gov/pubmed/11967075 PubMed 15667293 http://www.ncbi.nlm.nih.gov/pubmed/15667293 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18691156 http://www.ncbi.nlm.nih.gov/pubmed/18691156 PubMed 2200672 http://www.ncbi.nlm.nih.gov/pubmed/2200672 PubMed 2543955 http://www.ncbi.nlm.nih.gov/pubmed/2543955 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000493556 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000493556 RefSeq YP_026212 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026212 SMR P0AC26 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AC26 STRING 511145.b3367 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3367&targetmode=cogs STRING COG2116 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2116&targetmode=cogs TCDB 1.A.16.3 http://www.tcdb.org/search/result.php?tc=1.A.16.3 TIGRFAMs TIGR00790 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00790 UniProtKB NIRC_ECOLI http://www.uniprot.org/uniprot/NIRC_ECOLI UniProtKB-AC P0AC26 http://www.uniprot.org/uniprot/P0AC26 charge swissprot:NIRC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NIRC_ECOLI eggNOG COG2116 http://eggnogapi.embl.de/nog_data/html/tree/COG2116 eggNOG ENOG4107V9H http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107V9H epestfind swissprot:NIRC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NIRC_ECOLI garnier swissprot:NIRC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NIRC_ECOLI helixturnhelix swissprot:NIRC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NIRC_ECOLI hmoment swissprot:NIRC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NIRC_ECOLI iep swissprot:NIRC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NIRC_ECOLI inforesidue swissprot:NIRC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NIRC_ECOLI octanol swissprot:NIRC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NIRC_ECOLI pepcoil swissprot:NIRC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NIRC_ECOLI pepdigest swissprot:NIRC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NIRC_ECOLI pepinfo swissprot:NIRC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NIRC_ECOLI pepnet swissprot:NIRC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NIRC_ECOLI pepstats swissprot:NIRC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NIRC_ECOLI pepwheel swissprot:NIRC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NIRC_ECOLI pepwindow swissprot:NIRC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NIRC_ECOLI sigcleave swissprot:NIRC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NIRC_ECOLI ## Database ID URL or Descriptions # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG13040 pbl # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GOslim_component GO:0005575 cellular_component # InterPro IPR008258 Transglycosylase_SLT_dom_1 # InterPro IPR023346 Lysozyme-like_dom # Organism PBL_ECOLI Escherichia coli (strain K12) # PIR G65068 G65068 # Pfam PF01464 SLT # Proteomes UP000000625 Chromosome # RecName PBL_ECOLI Putative peptidoglycan-binding-like protein # SEQUENCE CAUTION Sequence=AAA83036.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the IagB/IpgF/P19 family. {ECO 0000305}. # SUBCELLULAR LOCATION PBL_ECOLI Periplasm {ECO 0000305}. # SUPFAM SSF53955 SSF53955 BLAST swissprot:PBL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PBL_ECOLI BioCyc EcoCyc:G7474-MONOMER http://biocyc.org/getid?id=EcoCyc:G7474-MONOMER DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 EchoBASE EB2855 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2855 EcoGene EG13040 http://www.ecogene.org/geneInfo.php?eg_id=EG13040 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 HOGENOM HOG000222008 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000222008&db=HOGENOM6 InParanoid Q46790 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46790 InterPro IPR008258 http://www.ebi.ac.uk/interpro/entry/IPR008258 InterPro IPR023346 http://www.ebi.ac.uk/interpro/entry/IPR023346 OMA VVYTRLN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VVYTRLN PSORT swissprot:PBL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PBL_ECOLI PSORT-B swissprot:PBL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PBL_ECOLI PSORT2 swissprot:PBL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PBL_ECOLI Pfam PF01464 http://pfam.xfam.org/family/PF01464 Phobius swissprot:PBL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PBL_ECOLI PhylomeDB Q46790 http://phylomedb.org/?seqid=Q46790 ProteinModelPortal Q46790 http://www.proteinmodelportal.org/query/uniprot/Q46790 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SUPFAM SSF53955 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53955 UniProtKB PBL_ECOLI http://www.uniprot.org/uniprot/PBL_ECOLI UniProtKB-AC Q46790 http://www.uniprot.org/uniprot/Q46790 charge swissprot:PBL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PBL_ECOLI epestfind swissprot:PBL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PBL_ECOLI garnier swissprot:PBL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PBL_ECOLI helixturnhelix swissprot:PBL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PBL_ECOLI hmoment swissprot:PBL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PBL_ECOLI iep swissprot:PBL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PBL_ECOLI inforesidue swissprot:PBL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PBL_ECOLI octanol swissprot:PBL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PBL_ECOLI pepcoil swissprot:PBL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PBL_ECOLI pepdigest swissprot:PBL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PBL_ECOLI pepinfo swissprot:PBL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PBL_ECOLI pepnet swissprot:PBL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PBL_ECOLI pepstats swissprot:PBL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PBL_ECOLI pepwheel swissprot:PBL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PBL_ECOLI pepwindow swissprot:PBL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PBL_ECOLI sigcleave swissprot:PBL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PBL_ECOLI ## Database ID URL or Descriptions # AltName T1SK_ECOLI Type I restriction enzyme EcoKI specificity protein # BioGrid 4262767 125 # DOMAIN T1SK_ECOLI Contains two DNA recognition domains, each specifying recognition of one of the two defined components of the target sequence. # EcoGene EG10460 hsdS # FUNCTION T1SK_ECOLI The M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of a bipartite DNA recognition sequence. In the presence of the R subunit the complex can also act as an endonuclease, binding to the same target sequence but cutting the DNA some distance from this site. Whether the DNA is cut or modified depends on the methylation state of the target sequence. When the target site is unmodified, the DNA is cut. When the target site is hemimethylated, the complex acts as a maintenance MTase modifying the DNA so that both strands become methylated. Subunit S dictates DNA sequences specificity. The EcoKI enzyme recognizes 5'- AACN(6)GTGC-3'. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0009307 DNA restriction-modification system; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # InterPro IPR000055 Restrct_endonuc_typeI_HsdS # KEGG_Brite ko01000 Enzymes # Organism T1SK_ECOLI Escherichia coli (strain K12) # PATRIC 32124302 VBIEscCol129921_4494 # PDB 2Y7C EM; 18.00 A; A=1-464 # PDB 2Y7H EM; 18.00 A; A=1-464 # PIR A30369 NDECKS # Pfam PF01420 Methylase_S; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # REBASE 3646 S.EcoKI # RecName T1SK_ECOLI Type-1 restriction enzyme EcoKI specificity protein # RefSeq NP_418768 NC_000913.3 # RefSeq WP_001272447 NZ_LN832404.1 # SIMILARITY Belongs to the type-I restriction system S methylase family. {ECO 0000305}. # SUBUNIT T1SK_ECOLI The type I restriction/modification system is composed of three polypeptides R, M and S. # eggNOG COG0732 LUCA # eggNOG ENOG4107XZC Bacteria BLAST swissprot:T1SK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:T1SK_ECOLI BioCyc ECOL316407:JW4311-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4311-MONOMER BioCyc EcoCyc:EG10460-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10460-MONOMER BioCyc MetaCyc:EG10460-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10460-MONOMER COG COG0732 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0732 DIP DIP-9945N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9945N DOI 10.1016/S0022-2836(83)80047-3 http://dx.doi.org/10.1016/S0022-2836(83)80047-3 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1093/nar/23.7.1177 http://dx.doi.org/10.1093/nar/23.7.1177 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL V00288 http://www.ebi.ac.uk/ena/data/view/V00288 EchoBASE EB0455 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0455 EcoGene EG10460 http://www.ecogene.org/geneInfo.php?eg_id=EG10460 EnsemblBacteria AAC77304 http://www.ensemblgenomes.org/id/AAC77304 EnsemblBacteria AAC77304 http://www.ensemblgenomes.org/id/AAC77304 EnsemblBacteria BAE78338 http://www.ensemblgenomes.org/id/BAE78338 EnsemblBacteria BAE78338 http://www.ensemblgenomes.org/id/BAE78338 EnsemblBacteria BAE78338 http://www.ensemblgenomes.org/id/BAE78338 EnsemblBacteria b4348 http://www.ensemblgenomes.org/id/b4348 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0009307 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009307 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 948867 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948867 HOGENOM HOG000295029 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000295029&db=HOGENOM6 InParanoid P05719 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P05719 IntAct P05719 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P05719* InterPro IPR000055 http://www.ebi.ac.uk/interpro/entry/IPR000055 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4311 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4311 KEGG_Gene eco:b4348 http://www.genome.jp/dbget-bin/www_bget?eco:b4348 KEGG_Orthology KO:K01154 http://www.genome.jp/dbget-bin/www_bget?KO:K01154 MINT MINT-1225773 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1225773 OMA MLAIDAC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MLAIDAC PDB 2Y7C http://www.ebi.ac.uk/pdbe-srv/view/entry/2Y7C PDB 2Y7H http://www.ebi.ac.uk/pdbe-srv/view/entry/2Y7H PDBsum 2Y7C http://www.ebi.ac.uk/pdbsum/2Y7C PDBsum 2Y7H http://www.ebi.ac.uk/pdbsum/2Y7H PSORT swissprot:T1SK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:T1SK_ECOLI PSORT-B swissprot:T1SK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:T1SK_ECOLI PSORT2 swissprot:T1SK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:T1SK_ECOLI Pfam PF01420 http://pfam.xfam.org/family/PF01420 Phobius swissprot:T1SK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:T1SK_ECOLI PhylomeDB P05719 http://phylomedb.org/?seqid=P05719 ProteinModelPortal P05719 http://www.proteinmodelportal.org/query/uniprot/P05719 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6304321 http://www.ncbi.nlm.nih.gov/pubmed/6304321 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 7739896 http://www.ncbi.nlm.nih.gov/pubmed/7739896 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 REBASE 3646 http://rebase.neb.com/rebase/enz/3646.html RefSeq NP_418768 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418768 RefSeq WP_001272447 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001272447 SMR P05719 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P05719 STRING 511145.b4348 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4348&targetmode=cogs STRING COG0732 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0732&targetmode=cogs UniProtKB T1SK_ECOLI http://www.uniprot.org/uniprot/T1SK_ECOLI UniProtKB-AC P05719 http://www.uniprot.org/uniprot/P05719 charge swissprot:T1SK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:T1SK_ECOLI eggNOG COG0732 http://eggnogapi.embl.de/nog_data/html/tree/COG0732 eggNOG ENOG4107XZC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107XZC epestfind swissprot:T1SK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:T1SK_ECOLI garnier swissprot:T1SK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:T1SK_ECOLI helixturnhelix swissprot:T1SK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:T1SK_ECOLI hmoment swissprot:T1SK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:T1SK_ECOLI iep swissprot:T1SK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:T1SK_ECOLI inforesidue swissprot:T1SK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:T1SK_ECOLI octanol swissprot:T1SK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:T1SK_ECOLI pepcoil swissprot:T1SK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:T1SK_ECOLI pepdigest swissprot:T1SK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:T1SK_ECOLI pepinfo swissprot:T1SK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:T1SK_ECOLI pepnet swissprot:T1SK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:T1SK_ECOLI pepstats swissprot:T1SK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:T1SK_ECOLI pepwheel swissprot:T1SK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:T1SK_ECOLI pepwindow swissprot:T1SK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:T1SK_ECOLI sigcleave swissprot:T1SK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:T1SK_ECOLI ## Database ID URL or Descriptions # BioGrid 4262179 20 # EcoGene EG13669 ybhM # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # Organism YBHM_ECOLI Escherichia coli (strain K12) # PATRIC 32116775 VBIEscCol129921_0813 # PIR C64815 C64815 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBHM_ECOLI Uncharacterized protein YbhM # RefSeq NP_415308 NC_000913.3 # RefSeq WP_000446911 NZ_LN832404.1 # SUBCELLULAR LOCATION YBHM_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # eggNOG COG0670 LUCA # eggNOG ENOG410733J Bacteria BLAST swissprot:YBHM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBHM_ECOLI BioCyc ECOL316407:JW0770-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0770-MONOMER BioCyc EcoCyc:G6404-MONOMER http://biocyc.org/getid?id=EcoCyc:G6404-MONOMER COG COG0670 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0670 DIP DIP-11416N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11416N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3433 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3433 EcoGene EG13669 http://www.ecogene.org/geneInfo.php?eg_id=EG13669 EnsemblBacteria AAC73874 http://www.ensemblgenomes.org/id/AAC73874 EnsemblBacteria AAC73874 http://www.ensemblgenomes.org/id/AAC73874 EnsemblBacteria BAA35446 http://www.ensemblgenomes.org/id/BAA35446 EnsemblBacteria BAA35446 http://www.ensemblgenomes.org/id/BAA35446 EnsemblBacteria BAA35446 http://www.ensemblgenomes.org/id/BAA35446 EnsemblBacteria b0787 http://www.ensemblgenomes.org/id/b0787 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 949001 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949001 HOGENOM HOG000118068 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118068&db=HOGENOM6 InParanoid P75769 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75769 KEGG_Gene ecj:JW0770 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0770 KEGG_Gene eco:b0787 http://www.genome.jp/dbget-bin/www_bget?eco:b0787 KEGG_Orthology KO:K06890 http://www.genome.jp/dbget-bin/www_bget?KO:K06890 OMA FTINAFL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FTINAFL PSORT swissprot:YBHM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBHM_ECOLI PSORT-B swissprot:YBHM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBHM_ECOLI PSORT2 swissprot:YBHM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBHM_ECOLI Phobius swissprot:YBHM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBHM_ECOLI ProteinModelPortal P75769 http://www.proteinmodelportal.org/query/uniprot/P75769 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415308 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415308 RefSeq WP_000446911 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000446911 STRING 511145.b0787 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0787&targetmode=cogs STRING COG0670 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0670&targetmode=cogs UniProtKB YBHM_ECOLI http://www.uniprot.org/uniprot/YBHM_ECOLI UniProtKB-AC P75769 http://www.uniprot.org/uniprot/P75769 charge swissprot:YBHM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBHM_ECOLI eggNOG COG0670 http://eggnogapi.embl.de/nog_data/html/tree/COG0670 eggNOG ENOG410733J http://eggnogapi.embl.de/nog_data/html/tree/ENOG410733J epestfind swissprot:YBHM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBHM_ECOLI garnier swissprot:YBHM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBHM_ECOLI helixturnhelix swissprot:YBHM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBHM_ECOLI hmoment swissprot:YBHM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBHM_ECOLI iep swissprot:YBHM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBHM_ECOLI inforesidue swissprot:YBHM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBHM_ECOLI octanol swissprot:YBHM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBHM_ECOLI pepcoil swissprot:YBHM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBHM_ECOLI pepdigest swissprot:YBHM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBHM_ECOLI pepinfo swissprot:YBHM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBHM_ECOLI pepnet swissprot:YBHM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBHM_ECOLI pepstats swissprot:YBHM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBHM_ECOLI pepwheel swissprot:YBHM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBHM_ECOLI pepwindow swissprot:YBHM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBHM_ECOLI sigcleave swissprot:YBHM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBHM_ECOLI ## Database ID URL or Descriptions # BioGrid 4260312 4 # EcoGene EG13493 yeaG # GO_function GO:0004672 protein kinase activity; IDA:EcoCyc. # GOslim_function GO:0016301 kinase activity # Gene3D 3.40.50.300 -; 2. # IntAct P0ACY3 7 # InterPro IPR010650 PrkA_C_dom # InterPro IPR013153 Prk_AAA_dom # InterPro IPR016230 Ser_kinase_PrkA # InterPro IPR027417 P-loop_NTPase # Organism YEAG_ECOLI Escherichia coli (strain K12) # PATRIC 32118877 VBIEscCol129921_1856 # PIR G64938 G64938 # PIRSF PIRSF000549 Ser_prot_kin # Pfam PF06798 PrkA # Pfam PF08298 AAA_PrkA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEAG_ECOLI Uncharacterized protein YeaG # RefSeq NP_416297 NC_000913.3 # RefSeq WP_001019882 NZ_CP014272.1 # SIMILARITY Belongs to the PrkA family. {ECO 0000305}. # SMART SM00763 AAA_PrkA # SUPFAM SSF52540 SSF52540; 2 # eggNOG COG2766 LUCA # eggNOG ENOG4105CYN Bacteria BLAST swissprot:YEAG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEAG_ECOLI BioCyc ECOL316407:JW1772-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1772-MONOMER BioCyc EcoCyc:G6969-MONOMER http://biocyc.org/getid?id=EcoCyc:G6969-MONOMER BioCyc MetaCyc:G6969-MONOMER http://biocyc.org/getid?id=MetaCyc:G6969-MONOMER COG COG2766 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2766 DIP DIP-35826N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35826N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3266 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3266 EcoGene EG13493 http://www.ecogene.org/geneInfo.php?eg_id=EG13493 EnsemblBacteria AAC74853 http://www.ensemblgenomes.org/id/AAC74853 EnsemblBacteria AAC74853 http://www.ensemblgenomes.org/id/AAC74853 EnsemblBacteria BAA15580 http://www.ensemblgenomes.org/id/BAA15580 EnsemblBacteria BAA15580 http://www.ensemblgenomes.org/id/BAA15580 EnsemblBacteria BAA15580 http://www.ensemblgenomes.org/id/BAA15580 EnsemblBacteria b1783 http://www.ensemblgenomes.org/id/b1783 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004672 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004672 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 946297 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946297 HOGENOM HOG000260079 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260079&db=HOGENOM6 InParanoid P0ACY3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACY3 IntAct P0ACY3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACY3* InterPro IPR010650 http://www.ebi.ac.uk/interpro/entry/IPR010650 InterPro IPR013153 http://www.ebi.ac.uk/interpro/entry/IPR013153 InterPro IPR016230 http://www.ebi.ac.uk/interpro/entry/IPR016230 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Gene ecj:JW1772 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1772 KEGG_Gene eco:b1783 http://www.genome.jp/dbget-bin/www_bget?eco:b1783 KEGG_Orthology KO:K07180 http://www.genome.jp/dbget-bin/www_bget?KO:K07180 MINT MINT-1223278 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1223278 OMA EPHTLEM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EPHTLEM PSORT swissprot:YEAG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEAG_ECOLI PSORT-B swissprot:YEAG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEAG_ECOLI PSORT2 swissprot:YEAG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEAG_ECOLI Pfam PF06798 http://pfam.xfam.org/family/PF06798 Pfam PF08298 http://pfam.xfam.org/family/PF08298 Phobius swissprot:YEAG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEAG_ECOLI PhylomeDB P0ACY3 http://phylomedb.org/?seqid=P0ACY3 ProteinModelPortal P0ACY3 http://www.proteinmodelportal.org/query/uniprot/P0ACY3 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416297 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416297 RefSeq WP_001019882 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001019882 SMART SM00763 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00763 STRING 511145.b1783 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1783&targetmode=cogs STRING COG2766 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2766&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB YEAG_ECOLI http://www.uniprot.org/uniprot/YEAG_ECOLI UniProtKB-AC P0ACY3 http://www.uniprot.org/uniprot/P0ACY3 charge swissprot:YEAG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEAG_ECOLI eggNOG COG2766 http://eggnogapi.embl.de/nog_data/html/tree/COG2766 eggNOG ENOG4105CYN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CYN epestfind swissprot:YEAG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEAG_ECOLI garnier swissprot:YEAG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEAG_ECOLI helixturnhelix swissprot:YEAG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEAG_ECOLI hmoment swissprot:YEAG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEAG_ECOLI iep swissprot:YEAG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEAG_ECOLI inforesidue swissprot:YEAG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEAG_ECOLI octanol swissprot:YEAG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEAG_ECOLI pepcoil swissprot:YEAG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEAG_ECOLI pepdigest swissprot:YEAG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEAG_ECOLI pepinfo swissprot:YEAG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEAG_ECOLI pepnet swissprot:YEAG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEAG_ECOLI pepstats swissprot:YEAG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEAG_ECOLI pepwheel swissprot:YEAG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEAG_ECOLI pepwindow swissprot:YEAG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEAG_ECOLI sigcleave swissprot:YEAG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEAG_ECOLI ## Database ID URL or Descriptions # CATALYTIC ACTIVITY Uroporphyrinogen III = coproporphyrinogen + 4 CO(2). {ECO:0000255|HAMAP-Rule MF_00218}. # CDD cd00717 URO-D # EcoGene EG11543 hemE # FUNCTION DCUP_ECOLI Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. {ECO 0000255|HAMAP-Rule MF_00218}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004853 uroporphyrinogen decarboxylase activity; IMP:EcoCyc. # GO_process GO:0006779 porphyrin-containing compound biosynthetic process; IMP:EcoliWiki. # GO_process GO:0006780 uroporphyrinogen III biosynthetic process; IMP:EcoliWiki. # GO_process GO:0006783 heme biosynthetic process; IMP:EcoliWiki. # GO_process GO:0019353 protoporphyrinogen IX biosynthetic process from glutamate; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # HAMAP MF_00218 URO_D # IntAct P29680 5 # InterPro IPR000257 Uroporphyrinogen_deCOase # InterPro IPR006361 Uroporphyrinogen_deCO2ase_HemE # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00860 Porphyrin and chlorophyll metabolism # Organism DCUP_ECOLI Escherichia coli (strain K12) # PATHWAY Porphyrin-containing compound metabolism; protoporphyrin- IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. {ECO 0000255|HAMAP-Rule:MF_00218}. # PATRIC 32123517 VBIEscCol129921_4111 # PIR H65206 H65206 # PROSITE PS00906 UROD_1 # PROSITE PS00907 UROD_2 # Pfam PF01208 URO-D # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Uroporphyrinogen decarboxylase {ECO:0000255|HAMAP-Rule MF_00218} # RefSeq NP_418425 NC_000913.3 # RefSeq WP_000137657 NZ_LN832404.1 # SIMILARITY Belongs to the uroporphyrinogen decarboxylase family. {ECO:0000255|HAMAP-Rule MF_00218}. # SUBCELLULAR LOCATION DCUP_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00218}. # SUBUNIT Homodimer. {ECO:0000255|HAMAP-Rule MF_00218}. # TIGRFAMs TIGR01464 hemE # UniPathway UPA00251 UER00321 # eggNOG COG0407 LUCA # eggNOG ENOG4105CFZ Bacteria BLAST swissprot:DCUP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DCUP_ECOLI BioCyc ECOL316407:JW3961-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3961-MONOMER BioCyc EcoCyc:UROGENDECARBOX-MONOMER http://biocyc.org/getid?id=EcoCyc:UROGENDECARBOX-MONOMER BioCyc MetaCyc:UROGENDECARBOX-MONOMER http://biocyc.org/getid?id=MetaCyc:UROGENDECARBOX-MONOMER COG COG0407 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0407 DOI 10.1016/0378-1119(93)90233-S http://dx.doi.org/10.1016/0378-1119(93)90233-S DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.1.1.37 {ECO:0000255|HAMAP-Rule:MF_00218} http://www.genome.jp/dbget-bin/www_bget?EC:4.1.1.37 {ECO:0000255|HAMAP-Rule:MF_00218} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D12624 http://www.ebi.ac.uk/ena/data/view/D12624 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 4.1.1.37 {ECO:0000255|HAMAP-Rule:MF_00218} http://enzyme.expasy.org/EC/4.1.1.37 {ECO:0000255|HAMAP-Rule:MF_00218} EchoBASE EB1505 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1505 EcoGene EG11543 http://www.ecogene.org/geneInfo.php?eg_id=EG11543 EnsemblBacteria AAC76971 http://www.ensemblgenomes.org/id/AAC76971 EnsemblBacteria AAC76971 http://www.ensemblgenomes.org/id/AAC76971 EnsemblBacteria BAE77322 http://www.ensemblgenomes.org/id/BAE77322 EnsemblBacteria BAE77322 http://www.ensemblgenomes.org/id/BAE77322 EnsemblBacteria BAE77322 http://www.ensemblgenomes.org/id/BAE77322 EnsemblBacteria b3997 http://www.ensemblgenomes.org/id/b3997 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004853 GO_process GO:0006779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006779 GO_process GO:0006780 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006780 GO_process GO:0006783 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006783 GO_process GO:0019353 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019353 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GeneID 948497 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948497 HAMAP MF_00218 http://hamap.expasy.org/unirule/MF_00218 HOGENOM HOG000253896 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000253896&db=HOGENOM6 InParanoid P29680 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P29680 IntAct P29680 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P29680* IntEnz 4.1.1.37 {ECO:0000255|HAMAP-Rule:MF_00218} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.1.37 {ECO:0000255|HAMAP-Rule:MF_00218} InterPro IPR000257 http://www.ebi.ac.uk/interpro/entry/IPR000257 InterPro IPR006361 http://www.ebi.ac.uk/interpro/entry/IPR006361 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3961 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3961 KEGG_Gene eco:b3997 http://www.genome.jp/dbget-bin/www_bget?eco:b3997 KEGG_Orthology KO:K01599 http://www.genome.jp/dbget-bin/www_bget?KO:K01599 KEGG_Pathway ko00860 http://www.genome.jp/kegg-bin/show_pathway?ko00860 KEGG_Reaction rn:R03197 http://www.genome.jp/dbget-bin/www_bget?rn:R03197 KEGG_Reaction rn:R04972 http://www.genome.jp/dbget-bin/www_bget?rn:R04972 OMA GSSKDFR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GSSKDFR PROSITE PS00906 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00906 PROSITE PS00907 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00907 PSORT swissprot:DCUP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DCUP_ECOLI PSORT-B swissprot:DCUP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DCUP_ECOLI PSORT2 swissprot:DCUP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DCUP_ECOLI Pfam PF01208 http://pfam.xfam.org/family/PF01208 Phobius swissprot:DCUP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DCUP_ECOLI PhylomeDB P29680 http://phylomedb.org/?seqid=P29680 ProteinModelPortal P29680 http://www.proteinmodelportal.org/query/uniprot/P29680 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8224882 http://www.ncbi.nlm.nih.gov/pubmed/8224882 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418425 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418425 RefSeq WP_000137657 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000137657 SMR P29680 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P29680 STRING 511145.b3997 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3997&targetmode=cogs STRING COG0407 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0407&targetmode=cogs TIGRFAMs TIGR01464 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01464 UniProtKB DCUP_ECOLI http://www.uniprot.org/uniprot/DCUP_ECOLI UniProtKB-AC P29680 http://www.uniprot.org/uniprot/P29680 charge swissprot:DCUP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DCUP_ECOLI eggNOG COG0407 http://eggnogapi.embl.de/nog_data/html/tree/COG0407 eggNOG ENOG4105CFZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CFZ epestfind swissprot:DCUP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DCUP_ECOLI garnier swissprot:DCUP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DCUP_ECOLI helixturnhelix swissprot:DCUP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DCUP_ECOLI hmoment swissprot:DCUP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DCUP_ECOLI iep swissprot:DCUP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DCUP_ECOLI inforesidue swissprot:DCUP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DCUP_ECOLI octanol swissprot:DCUP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DCUP_ECOLI pepcoil swissprot:DCUP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DCUP_ECOLI pepdigest swissprot:DCUP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DCUP_ECOLI pepinfo swissprot:DCUP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DCUP_ECOLI pepnet swissprot:DCUP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DCUP_ECOLI pepstats swissprot:DCUP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DCUP_ECOLI pepwheel swissprot:DCUP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DCUP_ECOLI pepwindow swissprot:DCUP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DCUP_ECOLI sigcleave swissprot:DCUP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DCUP_ECOLI ## Database ID URL or Descriptions # AltName Crotonobetainyl-CoA reductase {ECO:0000255|HAMAP-Rule MF_01052} # BioGrid 4263349 362 # COFACTOR CAIA_ECOLI Name=FAD; Xref=ChEBI CHEBI 57692; Evidence={ECO 0000269|PubMed 10209289}; Note=Binds 1 FAD per subunit. {ECO 0000269|PubMed 10209289}; # EcoGene EG11560 caiA # FUNCTION CAIA_ECOLI Catalyzes the reduction of crotonobetainyl-CoA to gamma- butyrobetainyl-CoA. # GO_function GO:0000062 fatty-acyl-CoA binding; IBA:GO_Central. # GO_function GO:0003995 acyl-CoA dehydrogenase activity; IBA:GO_Central. # GO_function GO:0009055 electron carrier activity; IBA:GO_Central. # GO_function GO:0050660 flavin adenine dinucleotide binding; IBA:GO_Central. # GO_function GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor; IBA:GO_Central. # GO_process GO:0009437 carnitine metabolic process; IEA:UniProtKB-UniPathway. # GO_process GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase; IBA:GO_Central. # GO_process GO:0055088 lipid homeostasis; IBA:GO_Central. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0042592 homeostatic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.540.10 -; 1. # HAMAP MF_01052 CaiA # IntAct P60584 5 # InterPro IPR006089 Acyl-CoA_DH_CS # InterPro IPR006091 Acyl-CoA_Oxase/DH_cen-dom # InterPro IPR009075 AcylCo_DH/oxidase_C # InterPro IPR009100 AcylCoA_DH/oxidase_NM_dom # InterPro IPR013786 AcylCoA_DH/ox_N # InterPro IPR023450 Crotonobetainyl-CoA_DHase_CaiA # KEGG_Brite ko01000 Enzymes # Organism CAIA_ECOLI Escherichia coli (strain K12) # PATHWAY Amine and polyamine metabolism; carnitine metabolism. {ECO:0000255|HAMAP-Rule MF_01052}. # PATRIC 32115173 VBIEscCol129921_0038 # PIR G64724 I41011 # PROSITE PS00072 ACYL_COA_DH_1 # PROSITE PS00073 ACYL_COA_DH_2 # Pfam PF00441 Acyl-CoA_dh_1 # Pfam PF02770 Acyl-CoA_dh_M # Pfam PF02771 Acyl-CoA_dh_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Crotonobetainyl-CoA dehydrogenase {ECO:0000255|HAMAP-Rule MF_01052} # RefSeq NP_414581 NC_000913.3 # RefSeq WP_000347117 NZ_LN832404.1 # SIMILARITY Belongs to the acyl-CoA dehydrogenase family. {ECO:0000255|HAMAP-Rule MF_01052}. # SUBUNIT CAIA_ECOLI Homotetramer. {ECO 0000255|HAMAP-Rule MF_01052, ECO 0000269|PubMed 10209289}. # SUPFAM SSF47203 SSF47203 # SUPFAM SSF56645 SSF56645 # eggNOG COG1960 LUCA # eggNOG ENOG4105C1G Bacteria BLAST swissprot:CAIA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CAIA_ECOLI BioCyc ECOL316407:JW0038-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0038-MONOMER BioCyc EcoCyc:CROBETREDUCT-MONOMER http://biocyc.org/getid?id=EcoCyc:CROBETREDUCT-MONOMER BioCyc MetaCyc:CROBETREDUCT-MONOMER http://biocyc.org/getid?id=MetaCyc:CROBETREDUCT-MONOMER COG COG1960 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1960 DIP DIP-9241N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9241N DOI 10.1016/S0167-4838(99)00032-1 http://dx.doi.org/10.1016/S0167-4838(99)00032-1 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1111/j.1365-2958.1994.tb00470.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb00470.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.3.99.- {ECO:0000255|HAMAP-Rule:MF_01052} http://www.genome.jp/dbget-bin/www_bget?EC:1.3.99.- {ECO:0000255|HAMAP-Rule:MF_01052} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X73904 http://www.ebi.ac.uk/ena/data/view/X73904 ENZYME 1.3.99.- {ECO:0000255|HAMAP-Rule:MF_01052} http://enzyme.expasy.org/EC/1.3.99.- {ECO:0000255|HAMAP-Rule:MF_01052} EchoBASE EB1521 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1521 EcoGene EG11560 http://www.ecogene.org/geneInfo.php?eg_id=EG11560 EnsemblBacteria AAC73150 http://www.ensemblgenomes.org/id/AAC73150 EnsemblBacteria AAC73150 http://www.ensemblgenomes.org/id/AAC73150 EnsemblBacteria BAB96608 http://www.ensemblgenomes.org/id/BAB96608 EnsemblBacteria BAB96608 http://www.ensemblgenomes.org/id/BAB96608 EnsemblBacteria BAB96608 http://www.ensemblgenomes.org/id/BAB96608 EnsemblBacteria b0039 http://www.ensemblgenomes.org/id/b0039 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000062 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000062 GO_function GO:0003995 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003995 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_function GO:0052890 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052890 GO_process GO:0009437 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009437 GO_process GO:0033539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033539 GO_process GO:0055088 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055088 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.540.10 http://www.cathdb.info/version/latest/superfamily/1.10.540.10 GeneID 949064 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949064 HAMAP MF_01052 http://hamap.expasy.org/unirule/MF_01052 HOGENOM HOG000131659 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000131659&db=HOGENOM6 InParanoid P60584 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P60584 IntAct P60584 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P60584* IntEnz 1.3.99.- {ECO:0000255|HAMAP-Rule:MF_01052} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.3.99.- {ECO:0000255|HAMAP-Rule:MF_01052} InterPro IPR006089 http://www.ebi.ac.uk/interpro/entry/IPR006089 InterPro IPR006091 http://www.ebi.ac.uk/interpro/entry/IPR006091 InterPro IPR009075 http://www.ebi.ac.uk/interpro/entry/IPR009075 InterPro IPR009100 http://www.ebi.ac.uk/interpro/entry/IPR009100 InterPro IPR013786 http://www.ebi.ac.uk/interpro/entry/IPR013786 InterPro IPR023450 http://www.ebi.ac.uk/interpro/entry/IPR023450 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0038 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0038 KEGG_Gene eco:b0039 http://www.genome.jp/dbget-bin/www_bget?eco:b0039 KEGG_Orthology KO:K08297 http://www.genome.jp/dbget-bin/www_bget?KO:K08297 OMA CRIPADC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CRIPADC PROSITE PS00072 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00072 PROSITE PS00073 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00073 PSORT swissprot:CAIA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CAIA_ECOLI PSORT-B swissprot:CAIA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CAIA_ECOLI PSORT2 swissprot:CAIA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CAIA_ECOLI Pfam PF00441 http://pfam.xfam.org/family/PF00441 Pfam PF02770 http://pfam.xfam.org/family/PF02770 Pfam PF02771 http://pfam.xfam.org/family/PF02771 Phobius swissprot:CAIA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CAIA_ECOLI PhylomeDB P60584 http://phylomedb.org/?seqid=P60584 ProteinModelPortal P60584 http://www.proteinmodelportal.org/query/uniprot/P60584 PubMed 10209289 http://www.ncbi.nlm.nih.gov/pubmed/10209289 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7815937 http://www.ncbi.nlm.nih.gov/pubmed/7815937 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414581 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414581 RefSeq WP_000347117 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000347117 SMR P60584 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P60584 STRING 511145.b0039 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0039&targetmode=cogs STRING COG1960 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1960&targetmode=cogs SUPFAM SSF47203 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47203 SUPFAM SSF56645 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56645 UniProtKB CAIA_ECOLI http://www.uniprot.org/uniprot/CAIA_ECOLI UniProtKB-AC P60584 http://www.uniprot.org/uniprot/P60584 charge swissprot:CAIA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CAIA_ECOLI eggNOG COG1960 http://eggnogapi.embl.de/nog_data/html/tree/COG1960 eggNOG ENOG4105C1G http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C1G epestfind swissprot:CAIA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CAIA_ECOLI garnier swissprot:CAIA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CAIA_ECOLI helixturnhelix swissprot:CAIA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CAIA_ECOLI hmoment swissprot:CAIA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CAIA_ECOLI iep swissprot:CAIA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CAIA_ECOLI inforesidue swissprot:CAIA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CAIA_ECOLI octanol swissprot:CAIA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CAIA_ECOLI pepcoil swissprot:CAIA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CAIA_ECOLI pepdigest swissprot:CAIA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CAIA_ECOLI pepinfo swissprot:CAIA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CAIA_ECOLI pepnet swissprot:CAIA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CAIA_ECOLI pepstats swissprot:CAIA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CAIA_ECOLI pepwheel swissprot:CAIA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CAIA_ECOLI pepwindow swissprot:CAIA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CAIA_ECOLI sigcleave swissprot:CAIA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CAIA_ECOLI ## Database ID URL or Descriptions # AltName NUOJ_ECOLI NADH dehydrogenase I subunit J # AltName NUOJ_ECOLI NDH-1 subunit J # AltName NUOJ_ECOLI NUO10 # BioGrid 4260509 26 # CATALYTIC ACTIVITY NUOJ_ECOLI NADH + a quinone = NAD(+) + a quinol. # EcoGene EG12090 nuoJ # FUNCTION NUOJ_ECOLI NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0030964 NADH dehydrogenase complex; IDA:EcoliWiki. # GO_component GO:0045272 plasma membrane respiratory chain complex I; IDA:EcoCyc. # GO_function GO:0008137 NADH dehydrogenase (ubiquinone) activity; IMP:EcoCyc. # GO_function GO:0048038 quinone binding; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # InterPro IPR001457 NADH_UbQ/plastoQ_OxRdtase_su6 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00190 Oxidative phosphorylation # KEGG_Pathway ko00910 Nitrogen metabolism # Organism NUOJ_ECOLI Escherichia coli (strain K12) # PATRIC 32119927 VBIEscCol129921_2373 # PIR F64999 F64999 # Pfam PF00499 Oxidored_q3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NUOJ_ECOLI NADH-quinone oxidoreductase subunit J # RefSeq NP_416783 NC_000913.3 # RefSeq WP_000393511 NZ_LN832404.1 # SIMILARITY Belongs to the complex I subunit 6 family. {ECO 0000305}. # SUBCELLULAR LOCATION NUOJ_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT NUOJ_ECOLI Composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex. # TCDB 3.D.1.1 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family # eggNOG COG0839 LUCA # eggNOG ENOG4107UFS Bacteria BLAST swissprot:NUOJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NUOJ_ECOLI BioCyc ECOL316407:JW2275-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2275-MONOMER BioCyc EcoCyc:NUOJ-MONOMER http://biocyc.org/getid?id=EcoCyc:NUOJ-MONOMER BioCyc MetaCyc:NUOJ-MONOMER http://biocyc.org/getid?id=MetaCyc:NUOJ-MONOMER COG COG0839 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0839 DIP DIP-59258N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-59258N DOI 10.1006/jmbi.1993.1488 http://dx.doi.org/10.1006/jmbi.1993.1488 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.6.5.11 http://www.genome.jp/dbget-bin/www_bget?EC:1.6.5.11 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X68301 http://www.ebi.ac.uk/ena/data/view/X68301 ENZYME 1.6.5.11 http://enzyme.expasy.org/EC/1.6.5.11 EchoBASE EB2014 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2014 EcoGene EG12090 http://www.ecogene.org/geneInfo.php?eg_id=EG12090 EnsemblBacteria AAC75340 http://www.ensemblgenomes.org/id/AAC75340 EnsemblBacteria AAC75340 http://www.ensemblgenomes.org/id/AAC75340 EnsemblBacteria BAA16108 http://www.ensemblgenomes.org/id/BAA16108 EnsemblBacteria BAA16108 http://www.ensemblgenomes.org/id/BAA16108 EnsemblBacteria BAA16108 http://www.ensemblgenomes.org/id/BAA16108 EnsemblBacteria b2280 http://www.ensemblgenomes.org/id/b2280 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0030964 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030964 GO_component GO:0045272 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045272 GO_function GO:0008137 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008137 GO_function GO:0048038 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048038 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GeneID 946756 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946756 HOGENOM HOG000262591 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000262591&db=HOGENOM6 InParanoid P0AFE0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFE0 IntEnz 1.6.5.11 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.6.5.11 InterPro IPR001457 http://www.ebi.ac.uk/interpro/entry/IPR001457 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2275 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2275 KEGG_Gene eco:b2280 http://www.genome.jp/dbget-bin/www_bget?eco:b2280 KEGG_Orthology KO:K00339 http://www.genome.jp/dbget-bin/www_bget?KO:K00339 KEGG_Pathway ko00190 http://www.genome.jp/kegg-bin/show_pathway?ko00190 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Reaction rn:R02166 http://www.genome.jp/dbget-bin/www_bget?rn:R02166 OMA IGVRHIG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IGVRHIG PSORT swissprot:NUOJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NUOJ_ECOLI PSORT-B swissprot:NUOJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NUOJ_ECOLI PSORT2 swissprot:NUOJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NUOJ_ECOLI Pfam PF00499 http://pfam.xfam.org/family/PF00499 Phobius swissprot:NUOJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NUOJ_ECOLI PhylomeDB P0AFE0 http://phylomedb.org/?seqid=P0AFE0 ProteinModelPortal P0AFE0 http://www.proteinmodelportal.org/query/uniprot/P0AFE0 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7690854 http://www.ncbi.nlm.nih.gov/pubmed/7690854 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416783 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416783 RefSeq WP_000393511 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000393511 SMR P0AFE0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFE0 STRING 511145.b2280 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2280&targetmode=cogs STRING COG0839 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0839&targetmode=cogs TCDB 3.D.1.1 http://www.tcdb.org/search/result.php?tc=3.D.1.1 UniProtKB NUOJ_ECOLI http://www.uniprot.org/uniprot/NUOJ_ECOLI UniProtKB-AC P0AFE0 http://www.uniprot.org/uniprot/P0AFE0 charge swissprot:NUOJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NUOJ_ECOLI eggNOG COG0839 http://eggnogapi.embl.de/nog_data/html/tree/COG0839 eggNOG ENOG4107UFS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107UFS epestfind swissprot:NUOJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NUOJ_ECOLI garnier swissprot:NUOJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NUOJ_ECOLI helixturnhelix swissprot:NUOJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NUOJ_ECOLI hmoment swissprot:NUOJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NUOJ_ECOLI iep swissprot:NUOJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NUOJ_ECOLI inforesidue swissprot:NUOJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NUOJ_ECOLI octanol swissprot:NUOJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NUOJ_ECOLI pepcoil swissprot:NUOJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NUOJ_ECOLI pepdigest swissprot:NUOJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NUOJ_ECOLI pepinfo swissprot:NUOJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NUOJ_ECOLI pepnet swissprot:NUOJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NUOJ_ECOLI pepstats swissprot:NUOJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NUOJ_ECOLI pepwheel swissprot:NUOJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NUOJ_ECOLI pepwindow swissprot:NUOJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NUOJ_ECOLI sigcleave swissprot:NUOJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NUOJ_ECOLI ## Database ID URL or Descriptions # AltName MHPB_ECOLI 3-carboxyethylcatechol 2,3-dioxygenase # BIOPHYSICOCHEMICAL PROPERTIES MHPB_ECOLI Kinetic parameters KM=26 uM for 2,3-dihydroxyphenylpropionic acid (at 20 degrees Celsius and pH 8) {ECO 0000269|PubMed 8399388, ECO 0000269|PubMed 8752345}; KM=36 uM for 2,3-dihydroxycinnamic acid (at 20 degrees Celsius and pH 8) {ECO 0000269|PubMed 8399388, ECO 0000269|PubMed 8752345}; KM=37 uM for methyl-2,3-dihydroxyphenylpropionate (at 20 degrees Celsius and pH 8) {ECO 0000269|PubMed 8399388, ECO 0000269|PubMed 8752345}; KM=90 uM for 3-methylcatechol (at 20 degrees Celsius and pH 8) {ECO 0000269|PubMed 8399388, ECO 0000269|PubMed 8752345}; KM=94 uM for 3-phenethylcatechol (at 20 degrees Celsius and pH 8) {ECO 0000269|PubMed 8399388, ECO 0000269|PubMed 8752345}; KM=154 uM for 3-propylcatechol (at 20 degrees Celsius and pH 8) {ECO 0000269|PubMed 8399388, ECO 0000269|PubMed 8752345}; KM=185 uM for 3-ethylcatechol (at 20 degrees Celsius and pH 8) {ECO 0000269|PubMed 8399388, ECO 0000269|PubMed 8752345}; KM=300 uM for 2,3-dihydroxyphenoxyacetic acid (at 20 degrees Celsius and pH 8) {ECO 0000269|PubMed 8399388, ECO 0000269|PubMed 8752345}; KM=700 uM for catechol (at 20 degrees Celsius and pH 8) {ECO 0000269|PubMed 8399388, ECO 0000269|PubMed 8752345}; # BRENDA 1.13.11.16 2026 # BioGrid 4260730 12 # CATALYTIC ACTIVITY MHPB_ECOLI (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O(2) = (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioate. # CATALYTIC ACTIVITY MHPB_ECOLI 3-(2,3-dihydroxyphenyl)propanoate + O(2) = (2Z,4E)-2-hydroxy-6-oxonona-2,4-diene-1,9-dioate. # CDD cd07365 MhpB_like # EcoGene EG20274 mhpB # FUNCTION MHPB_ECOLI Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively. {ECO 0000269|PubMed 8399388}. # GO_function GO:0008198 ferrous iron binding; IDA:EcoCyc. # GO_function GO:0047070 3-carboxyethylcatechol 2,3-dioxygenase activity; IDA:EcoCyc. # GO_process GO:0019380 3-phenylpropionate catabolic process; IEA:UniProtKB-UniPathway. # GO_process GO:0019622 3-(3-hydroxy)phenylpropionate catabolic process; IMP:EcoCyc. # GO_process GO:0046271 phenylpropanoid catabolic process; IMP:EcoCyc. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0019748 secondary metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.830.10 -; 2. # HAMAP MF_01653 MhpB # IntAct P0ABR9 12 # InterPro IPR004183 Xdiol_dOase_suB # InterPro IPR023789 DHPP/DHXA_dioxygenase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00360 Phenylalanine metabolism # Organism MHPB_ECOLI Escherichia coli (strain K12) # PATHWAY MHPB_ECOLI Aromatic compound metabolism; 3-phenylpropanoate degradation. # PATRIC 32115829 VBIEscCol129921_0356 # PIR D64762 D64762 # Pfam PF02900 LigB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MHPB_ECOLI 2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase # RefSeq NP_414882 NC_000913.3 # RefSeq WP_000543457 NZ_LN832404.1 # SIMILARITY Belongs to the LigB/MhpB extradiol dioxygenase family. {ECO 0000305}. # SUBUNIT Homotetramer. {ECO:0000269|PubMed 8399388}. # SUPFAM SSF53213 SSF53213; 2 # eggNOG ENOG4105MI0 Bacteria # eggNOG ENOG410XPPS LUCA BLAST swissprot:MHPB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MHPB_ECOLI BioCyc ECOL316407:JW0339-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0339-MONOMER BioCyc EcoCyc:DHPDIOXYGEN-MONOMER http://biocyc.org/getid?id=EcoCyc:DHPDIOXYGEN-MONOMER BioCyc MetaCyc:DHPDIOXYGEN-MONOMER http://biocyc.org/getid?id=MetaCyc:DHPDIOXYGEN-MONOMER DIP DIP-10206N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10206N DOI 10.1016/0167-4838(93)90013-H http://dx.doi.org/10.1016/0167-4838(93)90013-H DOI 10.1021/bi048518t http://dx.doi.org/10.1021/bi048518t DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.13.11.16 http://www.genome.jp/dbget-bin/www_bget?EC:1.13.11.16 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D86239 http://www.ebi.ac.uk/ena/data/view/D86239 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EMBL Y09555 http://www.ebi.ac.uk/ena/data/view/Y09555 ENZYME 1.13.11.16 http://enzyme.expasy.org/EC/1.13.11.16 EchoBASE EB4167 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4167 EcoGene EG20274 http://www.ecogene.org/geneInfo.php?eg_id=EG20274 EnsemblBacteria AAC73451 http://www.ensemblgenomes.org/id/AAC73451 EnsemblBacteria AAC73451 http://www.ensemblgenomes.org/id/AAC73451 EnsemblBacteria BAE76130 http://www.ensemblgenomes.org/id/BAE76130 EnsemblBacteria BAE76130 http://www.ensemblgenomes.org/id/BAE76130 EnsemblBacteria BAE76130 http://www.ensemblgenomes.org/id/BAE76130 EnsemblBacteria b0348 http://www.ensemblgenomes.org/id/b0348 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008198 GO_function GO:0047070 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047070 GO_process GO:0019380 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019380 GO_process GO:0019622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019622 GO_process GO:0046271 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046271 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0019748 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019748 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.830.10 http://www.cathdb.info/version/latest/superfamily/3.40.830.10 GeneID 945047 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945047 HAMAP MF_01653 http://hamap.expasy.org/unirule/MF_01653 HOGENOM HOG000069851 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000069851&db=HOGENOM6 InParanoid P0ABR9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABR9 IntAct P0ABR9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABR9* IntEnz 1.13.11.16 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.13.11.16 InterPro IPR004183 http://www.ebi.ac.uk/interpro/entry/IPR004183 InterPro IPR023789 http://www.ebi.ac.uk/interpro/entry/IPR023789 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0339 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0339 KEGG_Gene eco:b0348 http://www.genome.jp/dbget-bin/www_bget?eco:b0348 KEGG_Orthology KO:K05713 http://www.genome.jp/dbget-bin/www_bget?KO:K05713 KEGG_Pathway ko00360 http://www.genome.jp/kegg-bin/show_pathway?ko00360 KEGG_Reaction rn:R04376 http://www.genome.jp/dbget-bin/www_bget?rn:R04376 KEGG_Reaction rn:R06788 http://www.genome.jp/dbget-bin/www_bget?rn:R06788 OMA HCLSHTP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HCLSHTP PSORT swissprot:MHPB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MHPB_ECOLI PSORT-B swissprot:MHPB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MHPB_ECOLI PSORT2 swissprot:MHPB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MHPB_ECOLI Pfam PF02900 http://pfam.xfam.org/family/PF02900 Phobius swissprot:MHPB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MHPB_ECOLI ProteinModelPortal P0ABR9 http://www.proteinmodelportal.org/query/uniprot/P0ABR9 PubMed 15491145 http://www.ncbi.nlm.nih.gov/pubmed/15491145 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8399388 http://www.ncbi.nlm.nih.gov/pubmed/8399388 PubMed 8752345 http://www.ncbi.nlm.nih.gov/pubmed/8752345 PubMed 9098055 http://www.ncbi.nlm.nih.gov/pubmed/9098055 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414882 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414882 RefSeq WP_000543457 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000543457 STRING 511145.b0348 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0348&targetmode=cogs SUPFAM SSF53213 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53213 UniProtKB MHPB_ECOLI http://www.uniprot.org/uniprot/MHPB_ECOLI UniProtKB-AC P0ABR9 http://www.uniprot.org/uniprot/P0ABR9 charge swissprot:MHPB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MHPB_ECOLI eggNOG ENOG4105MI0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105MI0 eggNOG ENOG410XPPS http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPPS epestfind swissprot:MHPB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MHPB_ECOLI garnier swissprot:MHPB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MHPB_ECOLI helixturnhelix swissprot:MHPB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MHPB_ECOLI hmoment swissprot:MHPB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MHPB_ECOLI iep swissprot:MHPB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MHPB_ECOLI inforesidue swissprot:MHPB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MHPB_ECOLI octanol swissprot:MHPB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MHPB_ECOLI pepcoil swissprot:MHPB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MHPB_ECOLI pepdigest swissprot:MHPB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MHPB_ECOLI pepinfo swissprot:MHPB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MHPB_ECOLI pepnet swissprot:MHPB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MHPB_ECOLI pepstats swissprot:MHPB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MHPB_ECOLI pepwheel swissprot:MHPB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MHPB_ECOLI pepwindow swissprot:MHPB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MHPB_ECOLI sigcleave swissprot:MHPB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MHPB_ECOLI ## Database ID URL or Descriptions # AltName Pyridoxal kinase 2 {ECO:0000303|PubMed 15249053} # BioGrid 4263486 7 # CATALYTIC ACTIVITY PDXY_ECOLI ATP + pyridoxal = ADP + pyridoxal 5'- phosphate. {ECO 0000269|PubMed 15249053, ECO 0000269|PubMed 9537380}. # CDD cd01173 pyridoxal_pyridoxamine_kinase # COFACTOR PDXY_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_01639}; # DISRUPTION PHENOTYPE Cells lacking this gene and cells lacking both pdxY and pdxK are not auxotrophs, meaning that the de novo pathway of PLP biosynthesis is functional. For PLP salvage, the pdxY single mutant can use both pyridoxine and pyridoxal, the pdxK single mutant can use pyridoxal but not pyridoxine, and the double mutant can no longer use both compounds. {ECO:0000269|PubMed 9537380}. # EcoGene EG13940 pdxY # FUNCTION PDXY_ECOLI Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP in vivo, but shows very low activity compared to PdxK. Displays a low level of pyridoxine kinase activity when overexpressed, which is however not physiologically relevant. {ECO 0000269|PubMed 15249053, ECO 0000269|PubMed 9537380}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008478 pyridoxal kinase activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0009443 pyridoxal 5'-phosphate salvage; IMP:EcoliWiki. # GO_process GO:0042817 pyridoxal metabolic process; IMP:EcoliWiki. # GO_process GO:0042819 vitamin B6 biosynthetic process; IMP:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.1190.20 -; 1. # HAMAP MF_01639 PdxY # IntAct P77150 2 # InterPro IPR004625 PyrdxlKinase # InterPro IPR013749 PM/HMP-P_kinase-1 # InterPro IPR023685 Pyridoxal_kinase_PdxY # InterPro IPR029056 Ribokinase-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00750 Vitamin B6 metabolism # Organism PDXY_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10534 PTHR10534 # PATHWAY Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxal: step 1/1. {ECO 0000269|PubMed:9537380}. # PATRIC 32118574 VBIEscCol129921_1707 # PDB 1TD2 X-ray; 2.22 A; A/B=1-287 # PDB 1VI9 X-ray; 1.96 A; A/B/C/D=2-287 # PIR F64920 F64920 # Pfam PF08543 Phos_pyr_kin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Pyridoxal kinase PdxY {ECO:0000303|PubMed 9537380} # RefSeq NP_416153 NC_000913.3 # SIMILARITY Belongs to the pyridoxine kinase family. PdxY subfamily. {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 15547280}. # SUPFAM SSF53613 SSF53613 # TIGRFAMs TIGR00687 pyridox_kin # UniPathway UPA01068 UER00298 # eggNOG COG2240 LUCA # eggNOG ENOG4107XGF Bacteria BLAST swissprot:PDXY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PDXY_ECOLI BioCyc ECOL316407:JW1628-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1628-MONOMER BioCyc EcoCyc:PDXY-MONOMER http://biocyc.org/getid?id=EcoCyc:PDXY-MONOMER BioCyc MetaCyc:PDXY-MONOMER http://biocyc.org/getid?id=MetaCyc:PDXY-MONOMER COG COG2240 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2240 DOI 10.1002/prot.20541 http://dx.doi.org/10.1002/prot.20541 DOI 10.1016/j.pep.2004.04.021 http://dx.doi.org/10.1016/j.pep.2004.04.021 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.186.23.8074-8082.2004 http://dx.doi.org/10.1128/JB.186.23.8074-8082.2004 EC_number EC:2.7.1.35 {ECO:0000269|PubMed:15249053, ECO:0000269|PubMed:9537380} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.35 {ECO:0000269|PubMed:15249053, ECO:0000269|PubMed:9537380} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.35 {ECO:0000269|PubMed:15249053, ECO:0000269|PubMed:9537380} http://enzyme.expasy.org/EC/2.7.1.35 {ECO:0000269|PubMed:15249053, ECO:0000269|PubMed:9537380} EchoBASE EB3699 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3699 EcoGene EG13940 http://www.ecogene.org/geneInfo.php?eg_id=EG13940 EnsemblBacteria AAC74708 http://www.ensemblgenomes.org/id/AAC74708 EnsemblBacteria AAC74708 http://www.ensemblgenomes.org/id/AAC74708 EnsemblBacteria BAA15397 http://www.ensemblgenomes.org/id/BAA15397 EnsemblBacteria BAA15397 http://www.ensemblgenomes.org/id/BAA15397 EnsemblBacteria BAA15397 http://www.ensemblgenomes.org/id/BAA15397 EnsemblBacteria b1636 http://www.ensemblgenomes.org/id/b1636 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008478 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008478 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0009443 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009443 GO_process GO:0042817 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042817 GO_process GO:0042819 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042819 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.1190.20 http://www.cathdb.info/version/latest/superfamily/3.40.1190.20 GeneID 946162 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946162 HAMAP MF_01639 http://hamap.expasy.org/unirule/MF_01639 HOGENOM HOG000258173 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000258173&db=HOGENOM6 InParanoid P77150 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77150 IntAct P77150 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77150* IntEnz 2.7.1.35 {ECO:0000269|PubMed:15249053, ECO:0000269|PubMed:9537380} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.35 {ECO:0000269|PubMed:15249053, ECO:0000269|PubMed:9537380} InterPro IPR004625 http://www.ebi.ac.uk/interpro/entry/IPR004625 InterPro IPR013749 http://www.ebi.ac.uk/interpro/entry/IPR013749 InterPro IPR023685 http://www.ebi.ac.uk/interpro/entry/IPR023685 InterPro IPR029056 http://www.ebi.ac.uk/interpro/entry/IPR029056 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1628 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1628 KEGG_Gene eco:b1636 http://www.genome.jp/dbget-bin/www_bget?eco:b1636 KEGG_Orthology KO:K00868 http://www.genome.jp/dbget-bin/www_bget?KO:K00868 KEGG_Pathway ko00750 http://www.genome.jp/kegg-bin/show_pathway?ko00750 KEGG_Reaction rn:R00174 http://www.genome.jp/dbget-bin/www_bget?rn:R00174 KEGG_Reaction rn:R01909 http://www.genome.jp/dbget-bin/www_bget?rn:R01909 KEGG_Reaction rn:R02493 http://www.genome.jp/dbget-bin/www_bget?rn:R02493 OMA CPNQLEL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CPNQLEL PANTHER PTHR10534 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10534 PDB 1TD2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1TD2 PDB 1VI9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1VI9 PDBsum 1TD2 http://www.ebi.ac.uk/pdbsum/1TD2 PDBsum 1VI9 http://www.ebi.ac.uk/pdbsum/1VI9 PSORT swissprot:PDXY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PDXY_ECOLI PSORT-B swissprot:PDXY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PDXY_ECOLI PSORT2 swissprot:PDXY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PDXY_ECOLI Pfam PF08543 http://pfam.xfam.org/family/PF08543 Phobius swissprot:PDXY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PDXY_ECOLI PhylomeDB P77150 http://phylomedb.org/?seqid=P77150 ProteinModelPortal P77150 http://www.proteinmodelportal.org/query/uniprot/P77150 PubMed 15249053 http://www.ncbi.nlm.nih.gov/pubmed/15249053 PubMed 15547280 http://www.ncbi.nlm.nih.gov/pubmed/15547280 PubMed 16021622 http://www.ncbi.nlm.nih.gov/pubmed/16021622 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9537380 http://www.ncbi.nlm.nih.gov/pubmed/9537380 RefSeq NP_416153 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416153 SMR P77150 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77150 STRING 511145.b1636 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1636&targetmode=cogs STRING COG2240 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2240&targetmode=cogs SUPFAM SSF53613 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53613 TIGRFAMs TIGR00687 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00687 UniProtKB PDXY_ECOLI http://www.uniprot.org/uniprot/PDXY_ECOLI UniProtKB-AC P77150 http://www.uniprot.org/uniprot/P77150 charge swissprot:PDXY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PDXY_ECOLI eggNOG COG2240 http://eggnogapi.embl.de/nog_data/html/tree/COG2240 eggNOG ENOG4107XGF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107XGF epestfind swissprot:PDXY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PDXY_ECOLI garnier swissprot:PDXY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PDXY_ECOLI helixturnhelix swissprot:PDXY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PDXY_ECOLI hmoment swissprot:PDXY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PDXY_ECOLI iep swissprot:PDXY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PDXY_ECOLI inforesidue swissprot:PDXY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PDXY_ECOLI octanol swissprot:PDXY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PDXY_ECOLI pepcoil swissprot:PDXY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PDXY_ECOLI pepdigest swissprot:PDXY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PDXY_ECOLI pepinfo swissprot:PDXY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PDXY_ECOLI pepnet swissprot:PDXY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PDXY_ECOLI pepstats swissprot:PDXY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PDXY_ECOLI pepwheel swissprot:PDXY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PDXY_ECOLI pepwindow swissprot:PDXY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PDXY_ECOLI sigcleave swissprot:PDXY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PDXY_ECOLI ## Database ID URL or Descriptions # ENZYME REGULATION Inhibited by arsenate. {ECO:0000269|PubMed 9680209}. # EcoGene EG13132 znuC # FUNCTION ZNUC_ECOLI Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system. {ECO 0000255|HAMAP-Rule MF_01725, ECO 0000269|PubMed 9680209}. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IEA:UniProtKB-HAMAP. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0015633 zinc-transporting ATPase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0016887 ATPase activity; IEA:InterPro. # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.300 -; 1. # INDUCTION ZNUC_ECOLI Transcriptionally repressed by zur (zinc uptake regulator), in response to high extracellular zinc concentrations. {ECO 0000269|PubMed 16159766, ECO 0000269|PubMed 9680209}. # IntAct P0A9X1 13 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR017882 ZnuC # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00242 Zinc transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism ZNUC_ECOLI Escherichia coli (strain K12) # PATRIC 32119039 VBIEscCol129921_1937 # PIR B64948 B64948 # PROSITE PS50893 ABC_TRANSPORTER_2 # PROSITE PS51298 ZNUC # Pfam PF00005 ABC_tran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Zinc import ATP-binding protein ZnuC {ECO:0000255|HAMAP-Rule MF_01725} # RefSeq NP_416372 NC_000913.3 # RefSeq WP_000202996 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=U38702; Type=Frameshift; Positions=188; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ABC transporter superfamily. Zinc importer (TC 3.A.1.15.5) family. {ECO:0000255|HAMAP- Rule MF_01725}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|HAMAP- Rule MF_01725}. # SMART SM00382 AAA # SUBCELLULAR LOCATION ZNUC_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01725}; Peripheral membrane protein {ECO 0000255|HAMAP- Rule MF_01725}. # SUBUNIT The complex is composed of two ATP-binding proteins (ZnuC), two transmembrane proteins (ZnuB) and a solute-binding protein (ZnuA). {ECO:0000255|HAMAP-Rule MF_01725}. # SUPFAM SSF52540 SSF52540 # TCDB 3.A.1.15 the atp-binding cassette (abc) superfamily # eggNOG COG1121 LUCA # eggNOG ENOG4105FDK Bacteria BLAST swissprot:ZNUC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ZNUC_ECOLI BioCyc ECOL316407:JW1847-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1847-MONOMER BioCyc EcoCyc:ZNUC-MONOMER http://biocyc.org/getid?id=EcoCyc:ZNUC-MONOMER BioCyc MetaCyc:ZNUC-MONOMER http://biocyc.org/getid?id=MetaCyc:ZNUC-MONOMER COG COG1121 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1121 DIP DIP-48234N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48234N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1998.00883.x http://dx.doi.org/10.1046/j.1365-2958.1998.00883.x DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.187.18.6333-6340.2005 http://dx.doi.org/10.1128/JB.187.18.6333-6340.2005 EC_number EC:3.6.3.- {ECO:0000255|HAMAP-Rule:MF_01725} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.- {ECO:0000255|HAMAP-Rule:MF_01725} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U38702 http://www.ebi.ac.uk/ena/data/view/U38702 ENZYME 3.6.3.- {ECO:0000255|HAMAP-Rule:MF_01725} http://enzyme.expasy.org/EC/3.6.3.- {ECO:0000255|HAMAP-Rule:MF_01725} EchoBASE EB2931 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2931 EcoGene EG13132 http://www.ecogene.org/geneInfo.php?eg_id=EG13132 EnsemblBacteria AAC74928 http://www.ensemblgenomes.org/id/AAC74928 EnsemblBacteria AAC74928 http://www.ensemblgenomes.org/id/AAC74928 EnsemblBacteria BAA15666 http://www.ensemblgenomes.org/id/BAA15666 EnsemblBacteria BAA15666 http://www.ensemblgenomes.org/id/BAA15666 EnsemblBacteria BAA15666 http://www.ensemblgenomes.org/id/BAA15666 EnsemblBacteria b1858 http://www.ensemblgenomes.org/id/b1858 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0015633 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015633 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 946374 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946374 InParanoid P0A9X1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9X1 IntAct P0A9X1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9X1* IntEnz 3.6.3.- {ECO:0000255|HAMAP-Rule:MF_01725} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.- {ECO:0000255|HAMAP-Rule:MF_01725} InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR017882 http://www.ebi.ac.uk/interpro/entry/IPR017882 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1847 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1847 KEGG_Gene eco:b1858 http://www.genome.jp/dbget-bin/www_bget?eco:b1858 KEGG_Orthology KO:K09817 http://www.genome.jp/dbget-bin/www_bget?KO:K09817 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA SNFAMHA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SNFAMHA PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PROSITE PS51298 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51298 PSORT swissprot:ZNUC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ZNUC_ECOLI PSORT-B swissprot:ZNUC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ZNUC_ECOLI PSORT2 swissprot:ZNUC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ZNUC_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Phobius swissprot:ZNUC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ZNUC_ECOLI PhylomeDB P0A9X1 http://phylomedb.org/?seqid=P0A9X1 ProteinModelPortal P0A9X1 http://www.proteinmodelportal.org/query/uniprot/P0A9X1 PubMed 16159766 http://www.ncbi.nlm.nih.gov/pubmed/16159766 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9680209 http://www.ncbi.nlm.nih.gov/pubmed/9680209 RefSeq NP_416372 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416372 RefSeq WP_000202996 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000202996 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P0A9X1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9X1 STRING 511145.b1858 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1858&targetmode=cogs STRING COG1121 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1121&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.15 http://www.tcdb.org/search/result.php?tc=3.A.1.15 UniProtKB ZNUC_ECOLI http://www.uniprot.org/uniprot/ZNUC_ECOLI UniProtKB-AC P0A9X1 http://www.uniprot.org/uniprot/P0A9X1 charge swissprot:ZNUC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ZNUC_ECOLI eggNOG COG1121 http://eggnogapi.embl.de/nog_data/html/tree/COG1121 eggNOG ENOG4105FDK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FDK epestfind swissprot:ZNUC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ZNUC_ECOLI garnier swissprot:ZNUC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ZNUC_ECOLI helixturnhelix swissprot:ZNUC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ZNUC_ECOLI hmoment swissprot:ZNUC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ZNUC_ECOLI iep swissprot:ZNUC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ZNUC_ECOLI inforesidue swissprot:ZNUC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ZNUC_ECOLI octanol swissprot:ZNUC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ZNUC_ECOLI pepcoil swissprot:ZNUC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ZNUC_ECOLI pepdigest swissprot:ZNUC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ZNUC_ECOLI pepinfo swissprot:ZNUC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ZNUC_ECOLI pepnet swissprot:ZNUC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ZNUC_ECOLI pepstats swissprot:ZNUC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ZNUC_ECOLI pepwheel swissprot:ZNUC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ZNUC_ECOLI pepwindow swissprot:ZNUC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ZNUC_ECOLI sigcleave swissprot:ZNUC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ZNUC_ECOLI ## Database ID URL or Descriptions # BioGrid 4259465 14 # EcoGene EG10488 iap # FUNCTION IAP_ECOLI This protein, presumably an aminopeptidase, mediates the conversion of E.coli alkaline phosphatase isozyme 1, to isozymes 2 and 3 by removing, one by one, the two N-terminal arginine residues. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0004177 aminopeptidase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0043687 post-translational protein modification; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # InterPro IPR007484 Peptidase_M28 # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # Organism IAP_ECOLI Escherichia coli (strain K12) # PATRIC 32120912 VBIEscCol129921_2848 # PIR A28382 KZEC # Pfam PF04389 Peptidase_M28 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName IAP_ECOLI Alkaline phosphatase isozyme conversion protein # RefSeq NP_417233 NC_000913.3 # RefSeq WP_000490428 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase M28 family. M28C subfamily. {ECO 0000305}. # eggNOG COG2234 LUCA # eggNOG ENOG4108MXK Bacteria BLAST swissprot:IAP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:IAP_ECOLI BioCyc ECOL316407:JW2723-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2723-MONOMER BioCyc EcoCyc:EG10488-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10488-MONOMER BioCyc MetaCyc:EG10488-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10488-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.11.- http://www.genome.jp/dbget-bin/www_bget?EC:3.4.11.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M18270 http://www.ebi.ac.uk/ena/data/view/M18270 EMBL M74586 http://www.ebi.ac.uk/ena/data/view/M74586 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 ENZYME 3.4.11.- http://enzyme.expasy.org/EC/3.4.11.- EchoBASE EB0483 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0483 EcoGene EG10488 http://www.ecogene.org/geneInfo.php?eg_id=EG10488 EnsemblBacteria AAC75795 http://www.ensemblgenomes.org/id/AAC75795 EnsemblBacteria AAC75795 http://www.ensemblgenomes.org/id/AAC75795 EnsemblBacteria BAE76830 http://www.ensemblgenomes.org/id/BAE76830 EnsemblBacteria BAE76830 http://www.ensemblgenomes.org/id/BAE76830 EnsemblBacteria BAE76830 http://www.ensemblgenomes.org/id/BAE76830 EnsemblBacteria b2753 http://www.ensemblgenomes.org/id/b2753 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0004177 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004177 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0043687 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043687 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GeneID 947215 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947215 HOGENOM HOG000124091 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000124091&db=HOGENOM6 IntEnz 3.4.11 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.11 InterPro IPR007484 http://www.ebi.ac.uk/interpro/entry/IPR007484 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW2723 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2723 KEGG_Gene eco:b2753 http://www.genome.jp/dbget-bin/www_bget?eco:b2753 KEGG_Orthology KO:K09612 http://www.genome.jp/dbget-bin/www_bget?KO:K09612 OMA VEATNWS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VEATNWS PSORT swissprot:IAP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:IAP_ECOLI PSORT-B swissprot:IAP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:IAP_ECOLI PSORT2 swissprot:IAP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:IAP_ECOLI Pfam PF04389 http://pfam.xfam.org/family/PF04389 Phobius swissprot:IAP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:IAP_ECOLI ProteinModelPortal P10423 http://www.proteinmodelportal.org/query/uniprot/P10423 PubMed 1316900 http://www.ncbi.nlm.nih.gov/pubmed/1316900 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3316184 http://www.ncbi.nlm.nih.gov/pubmed/3316184 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417233 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417233 RefSeq WP_000490428 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000490428 STRING 511145.b2753 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2753&targetmode=cogs UniProtKB IAP_ECOLI http://www.uniprot.org/uniprot/IAP_ECOLI UniProtKB-AC P10423 http://www.uniprot.org/uniprot/P10423 charge swissprot:IAP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:IAP_ECOLI eggNOG COG2234 http://eggnogapi.embl.de/nog_data/html/tree/COG2234 eggNOG ENOG4108MXK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MXK epestfind swissprot:IAP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:IAP_ECOLI garnier swissprot:IAP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:IAP_ECOLI helixturnhelix swissprot:IAP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:IAP_ECOLI hmoment swissprot:IAP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:IAP_ECOLI iep swissprot:IAP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:IAP_ECOLI inforesidue swissprot:IAP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:IAP_ECOLI octanol swissprot:IAP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:IAP_ECOLI pepcoil swissprot:IAP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:IAP_ECOLI pepdigest swissprot:IAP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:IAP_ECOLI pepinfo swissprot:IAP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:IAP_ECOLI pepnet swissprot:IAP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:IAP_ECOLI pepstats swissprot:IAP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:IAP_ECOLI pepwheel swissprot:IAP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:IAP_ECOLI pepwindow swissprot:IAP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:IAP_ECOLI sigcleave swissprot:IAP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:IAP_ECOLI ## Database ID URL or Descriptions # AltName o-succinylbenzoyl-CoA synthetase {ECO:0000255|HAMAP-Rule MF_00731} # BioGrid 4262001 15 # CATALYTIC ACTIVITY ATP + 2-succinylbenzoate + CoA = AMP + diphosphate + 2-succinylbenzoyl-CoA. {ECO:0000255|HAMAP- Rule MF_00731}. # CDD cd05912 OSB_CoA_lg # EcoGene EG12437 menE # FUNCTION MENE_ECOLI Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl- CoA (OSB-CoA). {ECO 0000255|HAMAP-Rule MF_00731, ECO 0000269|PubMed 8626063}. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0008756 o-succinylbenzoate-CoA ligase activity; IDA:EcoliWiki. # GO_process GO:0009234 menaquinone biosynthetic process; IMP:EcoCyc. # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # HAMAP MF_00731 MenE # IntAct P37353 4 # InterPro IPR000873 AMP-dep_Synth/Lig # InterPro IPR010192 MenE # InterPro IPR020845 AMP-binding_CS # InterPro IPR025110 AMP-bd_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00130 Ubiquinone and other terpenoid-quinone biosynthesis # Organism MENE_ECOLI Escherichia coli (strain K12) # PATHWAY Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 5/7. {ECO 0000255|HAMAP-Rule:MF_00731}. # PATHWAY Quinol/quinone metabolism; menaquinone biosynthesis. {ECO:0000255|HAMAP-Rule MF_00731}. # PATRIC 32119887 VBIEscCol129921_2353 # PDB 5C5H X-ray; 2.40 A; A/B=1-451 # PIR B64997 B64997 # PROSITE PS00455 AMP_BINDING # Pfam PF00501 AMP-binding # Pfam PF13193 AMP-binding_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 2-succinylbenzoate--CoA ligase {ECO:0000255|HAMAP-Rule MF_00731} # RefSeq NP_416763 NC_000913.3 # RefSeq WP_000577625 NZ_LN832404.1 # SIMILARITY Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily. {ECO:0000255|HAMAP-Rule MF_00731, ECO:0000305}. # TIGRFAMs TIGR01923 menE # UniPathway UPA01057 UER00166 # eggNOG COG0318 LUCA # eggNOG ENOG4105CEY Bacteria BLAST swissprot:MENE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MENE_ECOLI BioCyc ECOL316407:JW2255-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2255-MONOMER BioCyc EcoCyc:O-SUCCINYLBENZOATE-COA-LIG-MONOMER http://biocyc.org/getid?id=EcoCyc:O-SUCCINYLBENZOATE-COA-LIG-MONOMER BioCyc MetaCyc:O-SUCCINYLBENZOATE-COA-LIG-MONOMER http://biocyc.org/getid?id=MetaCyc:O-SUCCINYLBENZOATE-COA-LIG-MONOMER COG COG0318 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0318 DIP DIP-10186N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10186N DOI 10.1016/0378-1119(95)00721-0 http://dx.doi.org/10.1016/0378-1119(95)00721-0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.2.1.26 {ECO:0000255|HAMAP-Rule:MF_00731} http://www.genome.jp/dbget-bin/www_bget?EC:6.2.1.26 {ECO:0000255|HAMAP-Rule:MF_00731} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L35031 http://www.ebi.ac.uk/ena/data/view/L35031 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 6.2.1.26 {ECO:0000255|HAMAP-Rule:MF_00731} http://enzyme.expasy.org/EC/6.2.1.26 {ECO:0000255|HAMAP-Rule:MF_00731} EchoBASE EB2332 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2332 EcoGene EG12437 http://www.ecogene.org/geneInfo.php?eg_id=EG12437 EnsemblBacteria AAC75320 http://www.ensemblgenomes.org/id/AAC75320 EnsemblBacteria AAC75320 http://www.ensemblgenomes.org/id/AAC75320 EnsemblBacteria BAA16084 http://www.ensemblgenomes.org/id/BAA16084 EnsemblBacteria BAA16084 http://www.ensemblgenomes.org/id/BAA16084 EnsemblBacteria BAA16084 http://www.ensemblgenomes.org/id/BAA16084 EnsemblBacteria b2260 http://www.ensemblgenomes.org/id/b2260 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008756 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008756 GO_process GO:0009234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009234 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GeneID 946741 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946741 HAMAP MF_00731 http://hamap.expasy.org/unirule/MF_00731 HOGENOM HOG000230003 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230003&db=HOGENOM6 InParanoid P37353 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37353 IntAct P37353 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37353* IntEnz 6.2.1.26 {ECO:0000255|HAMAP-Rule:MF_00731} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.2.1.26 {ECO:0000255|HAMAP-Rule:MF_00731} InterPro IPR000873 http://www.ebi.ac.uk/interpro/entry/IPR000873 InterPro IPR010192 http://www.ebi.ac.uk/interpro/entry/IPR010192 InterPro IPR020845 http://www.ebi.ac.uk/interpro/entry/IPR020845 InterPro IPR025110 http://www.ebi.ac.uk/interpro/entry/IPR025110 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2255 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2255 KEGG_Gene eco:b2260 http://www.genome.jp/dbget-bin/www_bget?eco:b2260 KEGG_Orthology KO:K01911 http://www.genome.jp/dbget-bin/www_bget?KO:K01911 KEGG_Pathway ko00130 http://www.genome.jp/kegg-bin/show_pathway?ko00130 KEGG_Reaction rn:R04030 http://www.genome.jp/dbget-bin/www_bget?rn:R04030 OMA FRASARC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FRASARC PDB 5C5H http://www.ebi.ac.uk/pdbe-srv/view/entry/5C5H PDBsum 5C5H http://www.ebi.ac.uk/pdbsum/5C5H PROSITE PS00455 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00455 PSORT swissprot:MENE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MENE_ECOLI PSORT-B swissprot:MENE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MENE_ECOLI PSORT2 swissprot:MENE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MENE_ECOLI Pfam PF00501 http://pfam.xfam.org/family/PF00501 Pfam PF13193 http://pfam.xfam.org/family/PF13193 Phobius swissprot:MENE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MENE_ECOLI PhylomeDB P37353 http://phylomedb.org/?seqid=P37353 ProteinModelPortal P37353 http://www.proteinmodelportal.org/query/uniprot/P37353 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8626063 http://www.ncbi.nlm.nih.gov/pubmed/8626063 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416763 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416763 RefSeq WP_000577625 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000577625 SMR P37353 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37353 STRING 511145.b2260 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2260&targetmode=cogs STRING COG0318 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0318&targetmode=cogs TIGRFAMs TIGR01923 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01923 UniProtKB MENE_ECOLI http://www.uniprot.org/uniprot/MENE_ECOLI UniProtKB-AC P37353 http://www.uniprot.org/uniprot/P37353 charge swissprot:MENE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MENE_ECOLI eggNOG COG0318 http://eggnogapi.embl.de/nog_data/html/tree/COG0318 eggNOG ENOG4105CEY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CEY epestfind swissprot:MENE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MENE_ECOLI garnier swissprot:MENE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MENE_ECOLI helixturnhelix swissprot:MENE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MENE_ECOLI hmoment swissprot:MENE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MENE_ECOLI iep swissprot:MENE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MENE_ECOLI inforesidue swissprot:MENE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MENE_ECOLI octanol swissprot:MENE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MENE_ECOLI pepcoil swissprot:MENE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MENE_ECOLI pepdigest swissprot:MENE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MENE_ECOLI pepinfo swissprot:MENE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MENE_ECOLI pepnet swissprot:MENE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MENE_ECOLI pepstats swissprot:MENE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MENE_ECOLI pepwheel swissprot:MENE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MENE_ECOLI pepwindow swissprot:MENE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MENE_ECOLI sigcleave swissprot:MENE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MENE_ECOLI ## Database ID URL or Descriptions # AltName SDHD_ECOLI D-serine deaminase # BRENDA 4.3.1.18 2026 # BioGrid 4260555 3 # CATALYTIC ACTIVITY SDHD_ECOLI D-serine = pyruvate + NH(3). # COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI 597326; # EcoGene EG10249 dsdA # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003941 L-serine ammonia-lyase activity; IBA:GO_Central. # GO_function GO:0008721 D-serine ammonia-lyase activity; IDA:CACAO. # GO_function GO:0016836 hydro-lyase activity; IDA:EcoliWiki. # GO_function GO:0030170 pyridoxal phosphate binding; IDA:EcoCyc. # GO_function GO:0030378 serine racemase activity; IBA:GO_Central. # GO_process GO:0006563 L-serine metabolic process; IBA:GO_Central. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0036088 D-serine catabolic process; IDA:EcoCyc. # GO_process GO:0046416 D-amino acid metabolic process; IEA:UniProtKB-HAMAP. # GO_process GO:0051410 detoxification of nitrogen compound; IMP:EcoCyc. # GO_process GO:0070178 D-serine metabolic process; IDA:EcoliWiki. # GO_process GO:0070179 D-serine biosynthetic process; IBA:GO_Central. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # HAMAP MF_01030 D_Ser_dehydrat # IntAct P00926 4 # InterPro IPR000634 Ser/Thr_deHydtase_PyrdxlP-BS # InterPro IPR001926 TrpB-like_PLP-dep # InterPro IPR011780 D_Ser_am_lyase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00260 Glycine, serine and threonine metabolism # Organism SDHD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10314:SF9 PTHR10314:SF9; 2 # PATRIC 32120111 VBIEscCol129921_2464 # PDB 3SS7 X-ray; 1.55 A; X=1-442 # PDB 3SS9 X-ray; 1.97 A; X=1-442 # PIR C65010 DWECS # PROSITE PS00165 DEHYDRATASE_SER_THR # Pfam PF00291 PALP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SDHD_ECOLI D-serine dehydratase # RefSeq NP_416867 NC_000913.3 # RefSeq WP_000426427 NZ_LN832404.1 # SIMILARITY Belongs to the serine/threonine dehydratase family. DsdA subfamily. {ECO 0000305}. # SUBUNIT SDHD_ECOLI Monomer. # SUPFAM SSF53686 SSF53686 # TIGRFAMs TIGR02035 D_Ser_am_lyase # eggNOG COG3048 LUCA # eggNOG ENOG4105BZC Bacteria BLAST swissprot:SDHD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SDHD_ECOLI BioCyc ECOL316407:JW2363-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2363-MONOMER BioCyc EcoCyc:DSERDEAM-MONOMER http://biocyc.org/getid?id=EcoCyc:DSERDEAM-MONOMER BioCyc MetaCyc:DSERDEAM-MONOMER http://biocyc.org/getid?id=MetaCyc:DSERDEAM-MONOMER COG COG3048 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3048 DOI 10.1016/0014-5793(81)80550-9 http://dx.doi.org/10.1016/0014-5793(81)80550-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1432-1033.1976.tb11095.x http://dx.doi.org/10.1111/j.1432-1033.1976.tb11095.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.3.1.18 http://www.genome.jp/dbget-bin/www_bget?EC:4.3.1.18 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01603 http://www.ebi.ac.uk/ena/data/view/J01603 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X86379 http://www.ebi.ac.uk/ena/data/view/X86379 ENZYME 4.3.1.18 http://enzyme.expasy.org/EC/4.3.1.18 EchoBASE EB0245 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0245 EcoGene EG10249 http://www.ecogene.org/geneInfo.php?eg_id=EG10249 EnsemblBacteria AAC75425 http://www.ensemblgenomes.org/id/AAC75425 EnsemblBacteria AAC75425 http://www.ensemblgenomes.org/id/AAC75425 EnsemblBacteria BAA16229 http://www.ensemblgenomes.org/id/BAA16229 EnsemblBacteria BAA16229 http://www.ensemblgenomes.org/id/BAA16229 EnsemblBacteria BAA16229 http://www.ensemblgenomes.org/id/BAA16229 EnsemblBacteria b2366 http://www.ensemblgenomes.org/id/b2366 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003941 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003941 GO_function GO:0008721 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008721 GO_function GO:0016836 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016836 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_function GO:0030378 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030378 GO_process GO:0006563 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006563 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0036088 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036088 GO_process GO:0046416 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046416 GO_process GO:0051410 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051410 GO_process GO:0070178 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070178 GO_process GO:0070179 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070179 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 946837 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946837 HAMAP MF_01030 http://hamap.expasy.org/unirule/MF_01030 HOGENOM HOG000218072 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218072&db=HOGENOM6 InParanoid P00926 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00926 IntAct P00926 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00926* IntEnz 4.3.1.18 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.3.1.18 InterPro IPR000634 http://www.ebi.ac.uk/interpro/entry/IPR000634 InterPro IPR001926 http://www.ebi.ac.uk/interpro/entry/IPR001926 InterPro IPR011780 http://www.ebi.ac.uk/interpro/entry/IPR011780 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2363 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2363 KEGG_Gene eco:b2366 http://www.genome.jp/dbget-bin/www_bget?eco:b2366 KEGG_Orthology KO:K01753 http://www.genome.jp/dbget-bin/www_bget?KO:K01753 KEGG_Pathway ko00260 http://www.genome.jp/kegg-bin/show_pathway?ko00260 KEGG_Reaction rn:R00221 http://www.genome.jp/dbget-bin/www_bget?rn:R00221 OMA ESDPNCF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ESDPNCF PANTHER PTHR10314:SF9 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10314:SF9 PDB 3SS7 http://www.ebi.ac.uk/pdbe-srv/view/entry/3SS7 PDB 3SS9 http://www.ebi.ac.uk/pdbe-srv/view/entry/3SS9 PDBsum 3SS7 http://www.ebi.ac.uk/pdbsum/3SS7 PDBsum 3SS9 http://www.ebi.ac.uk/pdbsum/3SS9 PROSITE PS00165 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00165 PSORT swissprot:SDHD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SDHD_ECOLI PSORT-B swissprot:SDHD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SDHD_ECOLI PSORT2 swissprot:SDHD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SDHD_ECOLI Pfam PF00291 http://pfam.xfam.org/family/PF00291 Phobius swissprot:SDHD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SDHD_ECOLI PhylomeDB P00926 http://phylomedb.org/?seqid=P00926 ProteinModelPortal P00926 http://www.proteinmodelportal.org/query/uniprot/P00926 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3053699 http://www.ncbi.nlm.nih.gov/pubmed/3053699 PubMed 6343359 http://www.ncbi.nlm.nih.gov/pubmed/6343359 PubMed 795658 http://www.ncbi.nlm.nih.gov/pubmed/795658 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9222324 http://www.ncbi.nlm.nih.gov/pubmed/9222324 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416867 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416867 RefSeq WP_000426427 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000426427 SMR P00926 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00926 STRING 511145.b2366 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2366&targetmode=cogs STRING COG3048 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3048&targetmode=cogs SUPFAM SSF53686 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53686 TIGRFAMs TIGR02035 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02035 UniProtKB SDHD_ECOLI http://www.uniprot.org/uniprot/SDHD_ECOLI UniProtKB-AC P00926 http://www.uniprot.org/uniprot/P00926 charge swissprot:SDHD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SDHD_ECOLI eggNOG COG3048 http://eggnogapi.embl.de/nog_data/html/tree/COG3048 eggNOG ENOG4105BZC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZC epestfind swissprot:SDHD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SDHD_ECOLI garnier swissprot:SDHD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SDHD_ECOLI helixturnhelix swissprot:SDHD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SDHD_ECOLI hmoment swissprot:SDHD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SDHD_ECOLI iep swissprot:SDHD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SDHD_ECOLI inforesidue swissprot:SDHD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SDHD_ECOLI octanol swissprot:SDHD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SDHD_ECOLI pepcoil swissprot:SDHD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SDHD_ECOLI pepdigest swissprot:SDHD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SDHD_ECOLI pepinfo swissprot:SDHD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SDHD_ECOLI pepnet swissprot:SDHD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SDHD_ECOLI pepstats swissprot:SDHD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SDHD_ECOLI pepwheel swissprot:SDHD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SDHD_ECOLI pepwindow swissprot:SDHD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SDHD_ECOLI sigcleave swissprot:SDHD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SDHD_ECOLI ## Database ID URL or Descriptions # BioGrid 4259996 3 # CDD cd06261 TM_PBP2 # EcoGene EG11632 potI # FUNCTION POTI_ECOLI Required for the activity of the bacterial periplasmic transport system of putrescine. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015594 putrescine-importing ATPase activity; IMP:EcoCyc. # GO_process GO:0015847 putrescine transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # Gene3D 1.10.3720.10 -; 1. # InterPro IPR000515 MetI-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00300 Putrescine transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism POTI_ECOLI Escherichia coli (strain K12) # PATRIC 32116919 VBIEscCol129921_0885 # PIR D45313 D45313 # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName POTI_ECOLI Putrescine transport system permease protein PotI # RefSeq NP_415378 NC_000913.3 # RefSeq WP_001061658 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION POTI_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00441, ECO 0000269|PubMed 15919996}. # SUPFAM SSF161098 SSF161098 # TCDB 3.A.1.11 the atp-binding cassette (abc) superfamily # eggNOG COG1177 LUCA # eggNOG ENOG4105D38 Bacteria BLAST swissprot:POTI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:POTI_ECOLI BioCyc ECOL316407:JW0841-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0841-MONOMER BioCyc EcoCyc:POTI-MONOMER http://biocyc.org/getid?id=EcoCyc:POTI-MONOMER BioCyc MetaCyc:POTI-MONOMER http://biocyc.org/getid?id=MetaCyc:POTI-MONOMER COG COG1177 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1177 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M93239 http://www.ebi.ac.uk/ena/data/view/M93239 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1589 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1589 EcoGene EG11632 http://www.ecogene.org/geneInfo.php?eg_id=EG11632 EnsemblBacteria AAC73944 http://www.ensemblgenomes.org/id/AAC73944 EnsemblBacteria AAC73944 http://www.ensemblgenomes.org/id/AAC73944 EnsemblBacteria BAA35568 http://www.ensemblgenomes.org/id/BAA35568 EnsemblBacteria BAA35568 http://www.ensemblgenomes.org/id/BAA35568 EnsemblBacteria BAA35568 http://www.ensemblgenomes.org/id/BAA35568 EnsemblBacteria b0857 http://www.ensemblgenomes.org/id/b0857 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015594 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015594 GO_process GO:0015847 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015847 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 945485 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945485 HOGENOM HOG000263700 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000263700&db=HOGENOM6 InParanoid P0AFL1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFL1 InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0841 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0841 KEGG_Gene eco:b0857 http://www.genome.jp/dbget-bin/www_bget?eco:b0857 KEGG_Orthology KO:K11074 http://www.genome.jp/dbget-bin/www_bget?KO:K11074 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA SVRMGVS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SVRMGVS PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:POTI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:POTI_ECOLI PSORT-B swissprot:POTI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:POTI_ECOLI PSORT2 swissprot:POTI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:POTI_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Phobius swissprot:POTI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:POTI_ECOLI PhylomeDB P0AFL1 http://phylomedb.org/?seqid=P0AFL1 ProteinModelPortal P0AFL1 http://www.proteinmodelportal.org/query/uniprot/P0AFL1 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8416922 http://www.ncbi.nlm.nih.gov/pubmed/8416922 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415378 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415378 RefSeq WP_001061658 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001061658 SMR P0AFL1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFL1 STRING 511145.b0857 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0857&targetmode=cogs STRING COG1177 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1177&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.11 http://www.tcdb.org/search/result.php?tc=3.A.1.11 UniProtKB POTI_ECOLI http://www.uniprot.org/uniprot/POTI_ECOLI UniProtKB-AC P0AFL1 http://www.uniprot.org/uniprot/P0AFL1 charge swissprot:POTI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:POTI_ECOLI eggNOG COG1177 http://eggnogapi.embl.de/nog_data/html/tree/COG1177 eggNOG ENOG4105D38 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D38 epestfind swissprot:POTI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:POTI_ECOLI garnier swissprot:POTI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:POTI_ECOLI helixturnhelix swissprot:POTI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:POTI_ECOLI hmoment swissprot:POTI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:POTI_ECOLI iep swissprot:POTI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:POTI_ECOLI inforesidue swissprot:POTI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:POTI_ECOLI octanol swissprot:POTI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:POTI_ECOLI pepcoil swissprot:POTI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:POTI_ECOLI pepdigest swissprot:POTI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:POTI_ECOLI pepinfo swissprot:POTI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:POTI_ECOLI pepnet swissprot:POTI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:POTI_ECOLI pepstats swissprot:POTI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:POTI_ECOLI pepwheel swissprot:POTI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:POTI_ECOLI pepwindow swissprot:POTI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:POTI_ECOLI sigcleave swissprot:POTI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:POTI_ECOLI ## Database ID URL or Descriptions # BioGrid 4260063 5 # EcoGene EG13872 ycdZ # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR009476 DUF1097 # Organism YCDZ_ECOLI Escherichia coli (strain K12) # PATRIC 32117305 VBIEscCol129921_1075 # PIR A64846 A64846 # Pfam PF06496 DUF1097 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCDZ_ECOLI Inner membrane protein YcdZ # RefSeq NP_415554 NC_000913.3 # RefSeq WP_001300785 NZ_LN832404.1 # SIMILARITY To E.coli YahC. {ECO 0000305}. # SUBCELLULAR LOCATION YCDZ_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG ENOG4108UQ5 Bacteria # eggNOG ENOG4111GJZ LUCA BLAST swissprot:YCDZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCDZ_ECOLI BioCyc ECOL316407:JW5147-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5147-MONOMER BioCyc EcoCyc:G6542-MONOMER http://biocyc.org/getid?id=EcoCyc:G6542-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3631 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3631 EcoGene EG13872 http://www.ecogene.org/geneInfo.php?eg_id=EG13872 EnsemblBacteria AAC74120 http://www.ensemblgenomes.org/id/AAC74120 EnsemblBacteria AAC74120 http://www.ensemblgenomes.org/id/AAC74120 EnsemblBacteria BAA35817 http://www.ensemblgenomes.org/id/BAA35817 EnsemblBacteria BAA35817 http://www.ensemblgenomes.org/id/BAA35817 EnsemblBacteria BAA35817 http://www.ensemblgenomes.org/id/BAA35817 EnsemblBacteria b1036 http://www.ensemblgenomes.org/id/b1036 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 945617 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945617 HOGENOM HOG000284435 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000284435&db=HOGENOM6 InterPro IPR009476 http://www.ebi.ac.uk/interpro/entry/IPR009476 KEGG_Gene ecj:JW5147 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5147 KEGG_Gene eco:b1036 http://www.genome.jp/dbget-bin/www_bget?eco:b1036 OMA WGWVAIS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WGWVAIS PSORT swissprot:YCDZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCDZ_ECOLI PSORT-B swissprot:YCDZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCDZ_ECOLI PSORT2 swissprot:YCDZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCDZ_ECOLI Pfam PF06496 http://pfam.xfam.org/family/PF06496 Phobius swissprot:YCDZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCDZ_ECOLI ProteinModelPortal P75916 http://www.proteinmodelportal.org/query/uniprot/P75916 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415554 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415554 RefSeq WP_001300785 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300785 STRING 511145.b1036 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1036&targetmode=cogs UniProtKB YCDZ_ECOLI http://www.uniprot.org/uniprot/YCDZ_ECOLI UniProtKB-AC P75916 http://www.uniprot.org/uniprot/P75916 charge swissprot:YCDZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCDZ_ECOLI eggNOG ENOG4108UQ5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UQ5 eggNOG ENOG4111GJZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111GJZ epestfind swissprot:YCDZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCDZ_ECOLI garnier swissprot:YCDZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCDZ_ECOLI helixturnhelix swissprot:YCDZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCDZ_ECOLI hmoment swissprot:YCDZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCDZ_ECOLI iep swissprot:YCDZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCDZ_ECOLI inforesidue swissprot:YCDZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCDZ_ECOLI octanol swissprot:YCDZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCDZ_ECOLI pepcoil swissprot:YCDZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCDZ_ECOLI pepdigest swissprot:YCDZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCDZ_ECOLI pepinfo swissprot:YCDZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCDZ_ECOLI pepnet swissprot:YCDZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCDZ_ECOLI pepstats swissprot:YCDZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCDZ_ECOLI pepwheel swissprot:YCDZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCDZ_ECOLI pepwindow swissprot:YCDZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCDZ_ECOLI sigcleave swissprot:YCDZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCDZ_ECOLI ## Database ID URL or Descriptions # EcoGene EG40005 insE1 # FUNCTION INSE1_ECOLI Involved in the transposition of the insertion sequence IS3. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IDA:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 1.10.10.60 -; 1. # InterPro IPR002514 Transposase_8 # InterPro IPR009057 Homeodomain-like # Organism INSE1_ECOLI Escherichia coli (strain K12) # PIR A64845 A64845 # Pfam PF01527 HTH_Tnp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSE1_ECOLI Transposase InsE for insertion sequence IS3A # RefSeq NP_061380 NC_002483.1 # RefSeq NP_061395 NC_002483.1 # RefSeq NP_414832 NC_000913.3 # RefSeq NP_414907 NC_000913.3 # RefSeq NP_415072 NC_000913.3 # RefSeq NP_415546 NC_000913.3 # RefSeq NP_416592 NC_000913.3 # RefSeq WP_000169527 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18026.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAE76083.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the transposase 8 family. {ECO 0000305}. # SUPFAM SSF46689 SSF46689 # eggNOG COG2963 LUCA # eggNOG ENOG41090WB Bacteria BLAST swissprot:INSE1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSE1_ECOLI BioCyc EcoCyc:G6534-MONOMER http://biocyc.org/getid?id=EcoCyc:G6534-MONOMER COG COG2963 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2963 DIP DIP-47960N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47960N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/13.6.2127 http://dx.doi.org/10.1093/nar/13.6.2127 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EMBL X02311 http://www.ebi.ac.uk/ena/data/view/X02311 EchoBASE EB4709 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4709 EcoGene EG40005 http://www.ecogene.org/geneInfo.php?eg_id=EG40005 EnsemblBacteria AAC73401 http://www.ensemblgenomes.org/id/AAC73401 EnsemblBacteria AAC73401 http://www.ensemblgenomes.org/id/AAC73401 EnsemblBacteria BAE76083 http://www.ensemblgenomes.org/id/BAE76083 EnsemblBacteria BAE76083 http://www.ensemblgenomes.org/id/BAE76083 EnsemblBacteria BAE76083 http://www.ensemblgenomes.org/id/BAE76083 EnsemblBacteria b0298 http://www.ensemblgenomes.org/id/b0298 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 GeneID 1263530 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263530 GeneID 1263552 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263552 GeneID 944952 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944952 GeneID 945584 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945584 GeneID 945759 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945759 GeneID 946616 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946616 GeneID 946900 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946900 HOGENOM HOG000266649 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000266649&db=HOGENOM6 InterPro IPR002514 http://www.ebi.ac.uk/interpro/entry/IPR002514 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 KEGG_Gene ecj:JW5036 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5036 KEGG_Gene eco:b0298 http://www.genome.jp/dbget-bin/www_bget?eco:b0298 KEGG_Gene eco:b0373 http://www.genome.jp/dbget-bin/www_bget?eco:b0373 KEGG_Gene eco:b0540 http://www.genome.jp/dbget-bin/www_bget?eco:b0540 KEGG_Gene eco:b1027 http://www.genome.jp/dbget-bin/www_bget?eco:b1027 KEGG_Gene eco:b2088 http://www.genome.jp/dbget-bin/www_bget?eco:b2088 KEGG_Orthology KO:K07483 http://www.genome.jp/dbget-bin/www_bget?KO:K07483 PSORT swissprot:INSE1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSE1_ECOLI PSORT-B swissprot:INSE1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSE1_ECOLI PSORT2 swissprot:INSE1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSE1_ECOLI Pfam PF01527 http://pfam.xfam.org/family/PF01527 Phobius swissprot:INSE1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSE1_ECOLI ProteinModelPortal P0CF66 http://www.proteinmodelportal.org/query/uniprot/P0CF66 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2987844 http://www.ncbi.nlm.nih.gov/pubmed/2987844 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_061380 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061380 RefSeq NP_061395 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061395 RefSeq NP_414832 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414832 RefSeq NP_414907 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414907 RefSeq NP_415072 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415072 RefSeq NP_415546 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415546 RefSeq NP_416592 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416592 RefSeq WP_000169527 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000169527 STRING 511145.b2088 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2088&targetmode=cogs STRING COG2963 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2963&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 UniProtKB INSE1_ECOLI http://www.uniprot.org/uniprot/INSE1_ECOLI UniProtKB-AC P0CF66 http://www.uniprot.org/uniprot/P0CF66 charge swissprot:INSE1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSE1_ECOLI eggNOG COG2963 http://eggnogapi.embl.de/nog_data/html/tree/COG2963 eggNOG ENOG41090WB http://eggnogapi.embl.de/nog_data/html/tree/ENOG41090WB epestfind swissprot:INSE1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSE1_ECOLI garnier swissprot:INSE1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSE1_ECOLI helixturnhelix swissprot:INSE1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSE1_ECOLI hmoment swissprot:INSE1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSE1_ECOLI iep swissprot:INSE1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSE1_ECOLI inforesidue swissprot:INSE1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSE1_ECOLI octanol swissprot:INSE1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSE1_ECOLI pepcoil swissprot:INSE1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSE1_ECOLI pepdigest swissprot:INSE1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSE1_ECOLI pepinfo swissprot:INSE1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSE1_ECOLI pepnet swissprot:INSE1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSE1_ECOLI pepstats swissprot:INSE1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSE1_ECOLI pepwheel swissprot:INSE1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSE1_ECOLI pepwindow swissprot:INSE1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSE1_ECOLI sigcleave swissprot:INSE1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSE1_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=1.5 mM for D-galactonate {ECO 0000269|Ref.7}; # CATALYTIC ACTIVITY DGOD_ECOLI D-galactonate = 2-dehydro-3-deoxy-D- galactonate + H(2)O. # COFACTOR DGOD_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250}; Note=Binds 1 Mg(2+) ion per subunit. {ECO 0000250}; # EcoGene EG20050 dgoD # FUNCTION DGOD_ECOLI Catalyzes the dehydration of D-galactonate to 2-keto-3- deoxy-D-galactonate. {ECO 0000269|PubMed 324806, ECO 0000269|Ref.7}. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008869 galactonate dehydratase activity; IEA:UniProtKB-HAMAP. # GO_process GO:0009063 cellular amino acid catabolic process; IEA:InterPro. # GO_process GO:0034194 D-galactonate catabolic process; IMP:EcoCyc. # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.120 -; 1. # Gene3D 3.30.390.10 -; 1. # HAMAP MF_01289 Galacton_dehydrat # INDUCTION DGOD_ECOLI Induced by galactonate, but not by glycerol, gluconate or galactose. Repressed by glucose. {ECO 0000269|PubMed 211976, ECO 0000269|PubMed 324806}. # InterPro IPR001354 MR/MLE/MAL # InterPro IPR013341 Mandelate_racemase_N_dom # InterPro IPR013342 Mandelate_racemase_C # InterPro IPR018110 Mandel_Rmase/mucon_lact_enz_CS # InterPro IPR023592 Galactonate_deHydtase # InterPro IPR029017 Enolase_N-like # InterPro IPR029065 Enolase_C-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00052 Galactose metabolism # MISCELLANEOUS DGOD_ECOLI Reaction proceeds via an anti dehydration. # Organism DGOD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR13794 PTHR13794 # PATHWAY Carbohydrate acid metabolism; D-galactonate degradation; D-glyceraldehyde 3-phosphate and pyruvate from D-galactonate: step 1/3. {ECO 0000269|PubMed:324806}. # PATRIC 32122879 VBIEscCol129921_3815 # PIR E65171 E65171 # PROSITE PS00908 MR_MLE_1 # PROSITE PS00909 MR_MLE_2 # Pfam PF02746 MR_MLE_N # Pfam PF13378 MR_MLE_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DGOD_ECOLI D-galactonate dehydratase # RefSeq WP_000705001 NZ_LN832404.1 # RefSeq YP_026237 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA62044.1; Type=Frameshift; Positions=1; Note=The frameshift in position 1 caused the prediction of an ORF that fused dgoA and dgoD.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily. {ECO 0000305}. # SMART SM00922 MR_MLE # SUPFAM SSF51604 SSF51604 # SUPFAM SSF54826 SSF54826 # UniPathway UPA00081 UER00518 # eggNOG COG4948 LUCA # eggNOG ENOG4105CXK Bacteria BLAST swissprot:DGOD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DGOD_ECOLI BioCyc ECOL316407:JW5629-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5629-MONOMER BioCyc EcoCyc:GALACTONATE-DEHYDRATASE-MONOMER http://biocyc.org/getid?id=EcoCyc:GALACTONATE-DEHYDRATASE-MONOMER BioCyc MetaCyc:GALACTONATE-DEHYDRATASE-MONOMER http://biocyc.org/getid?id=MetaCyc:GALACTONATE-DEHYDRATASE-MONOMER COG COG4948 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4948 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1007/BF00415730 http://dx.doi.org/10.1007/BF00415730 DOI 10.1016/0014-5793(77)80234-2 http://dx.doi.org/10.1016/0014-5793(77)80234-2 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.1.6 http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.6 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 4.2.1.6 http://enzyme.expasy.org/EC/4.2.1.6 EchoBASE EB4309 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4309 EcoGene EG20050 http://www.ecogene.org/geneInfo.php?eg_id=EG20050 EnsemblBacteria AAT48197 http://www.ensemblgenomes.org/id/AAT48197 EnsemblBacteria AAT48197 http://www.ensemblgenomes.org/id/AAT48197 EnsemblBacteria BAE77602 http://www.ensemblgenomes.org/id/BAE77602 EnsemblBacteria BAE77602 http://www.ensemblgenomes.org/id/BAE77602 EnsemblBacteria BAE77602 http://www.ensemblgenomes.org/id/BAE77602 EnsemblBacteria b4478 http://www.ensemblgenomes.org/id/b4478 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0008869 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008869 GO_process GO:0009063 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009063 GO_process GO:0034194 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034194 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.120 http://www.cathdb.info/version/latest/superfamily/3.20.20.120 Gene3D 3.30.390.10 http://www.cathdb.info/version/latest/superfamily/3.30.390.10 GeneID 2847765 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2847765 HAMAP MF_01289 http://hamap.expasy.org/unirule/MF_01289 HOGENOM HOG000113756 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000113756&db=HOGENOM6 InParanoid Q6BF17 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q6BF17 IntEnz 4.2.1.6 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.6 InterPro IPR001354 http://www.ebi.ac.uk/interpro/entry/IPR001354 InterPro IPR013341 http://www.ebi.ac.uk/interpro/entry/IPR013341 InterPro IPR013342 http://www.ebi.ac.uk/interpro/entry/IPR013342 InterPro IPR018110 http://www.ebi.ac.uk/interpro/entry/IPR018110 InterPro IPR023592 http://www.ebi.ac.uk/interpro/entry/IPR023592 InterPro IPR029017 http://www.ebi.ac.uk/interpro/entry/IPR029017 InterPro IPR029065 http://www.ebi.ac.uk/interpro/entry/IPR029065 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5629 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5629 KEGG_Gene eco:b4478 http://www.genome.jp/dbget-bin/www_bget?eco:b4478 KEGG_Orthology KO:K01684 http://www.genome.jp/dbget-bin/www_bget?KO:K01684 KEGG_Pathway ko00052 http://www.genome.jp/kegg-bin/show_pathway?ko00052 KEGG_Reaction rn:R03033 http://www.genome.jp/dbget-bin/www_bget?rn:R03033 OMA LHRPMAK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LHRPMAK PANTHER PTHR13794 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13794 PROSITE PS00908 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00908 PROSITE PS00909 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00909 PSORT swissprot:DGOD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DGOD_ECOLI PSORT-B swissprot:DGOD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DGOD_ECOLI PSORT2 swissprot:DGOD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DGOD_ECOLI Pfam PF02746 http://pfam.xfam.org/family/PF02746 Pfam PF13378 http://pfam.xfam.org/family/PF13378 Phobius swissprot:DGOD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DGOD_ECOLI PhylomeDB Q6BF17 http://phylomedb.org/?seqid=Q6BF17 ProteinModelPortal Q6BF17 http://www.proteinmodelportal.org/query/uniprot/Q6BF17 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 211976 http://www.ncbi.nlm.nih.gov/pubmed/211976 PubMed 324806 http://www.ncbi.nlm.nih.gov/pubmed/324806 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000705001 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000705001 RefSeq YP_026237 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026237 SMART SM00922 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00922 SMR Q6BF17 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q6BF17 STRING 511145.b4478 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4478&targetmode=cogs STRING COG4948 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4948&targetmode=cogs SUPFAM SSF51604 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51604 SUPFAM SSF54826 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54826 UniProtKB DGOD_ECOLI http://www.uniprot.org/uniprot/DGOD_ECOLI UniProtKB-AC Q6BF17 http://www.uniprot.org/uniprot/Q6BF17 charge swissprot:DGOD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DGOD_ECOLI eggNOG COG4948 http://eggnogapi.embl.de/nog_data/html/tree/COG4948 eggNOG ENOG4105CXK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CXK epestfind swissprot:DGOD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DGOD_ECOLI garnier swissprot:DGOD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DGOD_ECOLI helixturnhelix swissprot:DGOD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DGOD_ECOLI hmoment swissprot:DGOD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DGOD_ECOLI iep swissprot:DGOD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DGOD_ECOLI inforesidue swissprot:DGOD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DGOD_ECOLI octanol swissprot:DGOD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DGOD_ECOLI pepcoil swissprot:DGOD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DGOD_ECOLI pepdigest swissprot:DGOD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DGOD_ECOLI pepinfo swissprot:DGOD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DGOD_ECOLI pepnet swissprot:DGOD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DGOD_ECOLI pepstats swissprot:DGOD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DGOD_ECOLI pepwheel swissprot:DGOD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DGOD_ECOLI pepwindow swissprot:DGOD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DGOD_ECOLI sigcleave swissprot:DGOD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DGOD_ECOLI ## Database ID URL or Descriptions # AltName PEPT_ECOLI Aminotripeptidase # AltName PEPT_ECOLI Tripeptide aminopeptidase # BioGrid 4261675 14 # CATALYTIC ACTIVITY PEPT_ECOLI Release of the N-terminal residue from a tripeptide. # CDD cd03892 M20_peptT # COFACTOR PEPT_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 16021622}; Note=Binds 2 Zn(2+) ions per subunit. {ECO 0000269|PubMed 16021622}; # EcoGene EG11549 pepT # FUNCTION PEPT_ECOLI Cleaves the N-terminal amino acid of tripeptides. {ECO 0000250}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008237 metallopeptidase activity; IEA:UniProtKB-KW. # GO_function GO:0008270 zinc ion binding; IBA:GO_Central. # GO_function GO:0045148 tripeptide aminopeptidase activity; IDA:EcoCyc. # GO_process GO:0006518 peptide metabolic process; IDA:EcoCyc. # GO_process GO:0043171 peptide catabolic process; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.30.70.360 -; 1. # HAMAP MF_00550 Aminopeptidase_M20 # INTERACTION PEPT_ECOLI P0A858 tpiA; NbExp=4; IntAct=EBI-555639, EBI-368978; # IntAct P29745 19 # InterPro IPR001261 ArgE/DapE_CS # InterPro IPR002933 Peptidase_M20 # InterPro IPR010161 Peptidase_M20B # InterPro IPR011650 Peptidase_M20_dimer # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # Organism PEPT_ECOLI Escherichia coli (strain K12) # PATRIC 32117503 VBIEscCol129921_1174 # PDB 1VIX X-ray; 2.50 A; A/B=2-408 # PIR D64857 D64857 # PIRSF PIRSF037215 Peptidase_M20B # PROSITE PS00758 ARGE_DAPE_CPG2_1 # PROSITE PS00759 ARGE_DAPE_CPG2_2 # Pfam PF01546 Peptidase_M20 # Pfam PF07687 M20_dimer # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PEPT_ECOLI Peptidase T # RefSeq NP_415645 NC_000913.3 # RefSeq WP_000359434 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase M20B family. {ECO 0000305}. # SUBCELLULAR LOCATION PEPT_ECOLI Cytoplasm {ECO 0000250}. # SUBUNIT Homodimer. {ECO:0000305|PubMed 16021622}. # SUPFAM SSF55031 SSF55031 # TIGRFAMs TIGR01882 peptidase-T # eggNOG COG2195 LUCA # eggNOG ENOG4105D42 Bacteria BLAST swissprot:PEPT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PEPT_ECOLI BioCyc ECOL316407:JW1113-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1113-MONOMER BioCyc EcoCyc:EG11549-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11549-MONOMER BioCyc MetaCyc:EG11549-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11549-MONOMER COG COG2195 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2195 DIP DIP-10461N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10461N DOI 10.1002/prot.20541 http://dx.doi.org/10.1002/prot.20541 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.11.4 http://www.genome.jp/dbget-bin/www_bget?EC:3.4.11.4 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M64519 http://www.ebi.ac.uk/ena/data/view/M64519 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.4.11.4 http://enzyme.expasy.org/EC/3.4.11.4 EchoBASE EB1511 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1511 EcoGene EG11549 http://www.ecogene.org/geneInfo.php?eg_id=EG11549 EnsemblBacteria AAC74211 http://www.ensemblgenomes.org/id/AAC74211 EnsemblBacteria AAC74211 http://www.ensemblgenomes.org/id/AAC74211 EnsemblBacteria BAA35949 http://www.ensemblgenomes.org/id/BAA35949 EnsemblBacteria BAA35949 http://www.ensemblgenomes.org/id/BAA35949 EnsemblBacteria BAA35949 http://www.ensemblgenomes.org/id/BAA35949 EnsemblBacteria b1127 http://www.ensemblgenomes.org/id/b1127 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008237 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008237 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0045148 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045148 GO_process GO:0006518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006518 GO_process GO:0043171 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043171 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.30.70.360 http://www.cathdb.info/version/latest/superfamily/3.30.70.360 GeneID 946333 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946333 HAMAP MF_00550 http://hamap.expasy.org/unirule/MF_00550 HOGENOM HOG000032390 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000032390&db=HOGENOM6 InParanoid P29745 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P29745 IntAct P29745 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P29745* IntEnz 3.4.11.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.11.4 InterPro IPR001261 http://www.ebi.ac.uk/interpro/entry/IPR001261 InterPro IPR002933 http://www.ebi.ac.uk/interpro/entry/IPR002933 InterPro IPR010161 http://www.ebi.ac.uk/interpro/entry/IPR010161 InterPro IPR011650 http://www.ebi.ac.uk/interpro/entry/IPR011650 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW1113 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1113 KEGG_Gene eco:b1127 http://www.genome.jp/dbget-bin/www_bget?eco:b1127 KEGG_Orthology KO:K01258 http://www.genome.jp/dbget-bin/www_bget?KO:K01258 MINT MINT-1219063 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1219063 OMA YVYATIP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YVYATIP PDB 1VIX http://www.ebi.ac.uk/pdbe-srv/view/entry/1VIX PDBsum 1VIX http://www.ebi.ac.uk/pdbsum/1VIX PROSITE PS00758 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00758 PROSITE PS00759 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00759 PSORT swissprot:PEPT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PEPT_ECOLI PSORT-B swissprot:PEPT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PEPT_ECOLI PSORT2 swissprot:PEPT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PEPT_ECOLI Pfam PF01546 http://pfam.xfam.org/family/PF01546 Pfam PF07687 http://pfam.xfam.org/family/PF07687 Phobius swissprot:PEPT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PEPT_ECOLI PhylomeDB P29745 http://phylomedb.org/?seqid=P29745 ProteinModelPortal P29745 http://www.proteinmodelportal.org/query/uniprot/P29745 PubMed 16021622 http://www.ncbi.nlm.nih.gov/pubmed/16021622 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1939142 http://www.ncbi.nlm.nih.gov/pubmed/1939142 PubMed 8244951 http://www.ncbi.nlm.nih.gov/pubmed/8244951 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415645 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415645 RefSeq WP_000359434 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000359434 SMR P29745 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P29745 STRING 511145.b1127 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1127&targetmode=cogs STRING COG2195 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2195&targetmode=cogs SUPFAM SSF55031 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55031 TIGRFAMs TIGR01882 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01882 UniProtKB PEPT_ECOLI http://www.uniprot.org/uniprot/PEPT_ECOLI UniProtKB-AC P29745 http://www.uniprot.org/uniprot/P29745 charge swissprot:PEPT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PEPT_ECOLI eggNOG COG2195 http://eggnogapi.embl.de/nog_data/html/tree/COG2195 eggNOG ENOG4105D42 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D42 epestfind swissprot:PEPT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PEPT_ECOLI garnier swissprot:PEPT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PEPT_ECOLI helixturnhelix swissprot:PEPT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PEPT_ECOLI hmoment swissprot:PEPT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PEPT_ECOLI iep swissprot:PEPT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PEPT_ECOLI inforesidue swissprot:PEPT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PEPT_ECOLI octanol swissprot:PEPT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PEPT_ECOLI pepcoil swissprot:PEPT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PEPT_ECOLI pepdigest swissprot:PEPT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PEPT_ECOLI pepinfo swissprot:PEPT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PEPT_ECOLI pepnet swissprot:PEPT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PEPT_ECOLI pepstats swissprot:PEPT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PEPT_ECOLI pepwheel swissprot:PEPT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PEPT_ECOLI pepwindow swissprot:PEPT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PEPT_ECOLI sigcleave swissprot:PEPT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PEPT_ECOLI ## Database ID URL or Descriptions # AltName EIIB-Chb {ECO:0000303|PubMed 2092358} # AltName IVcel {ECO:0000303|PubMed 2092358} # AltName N,N'-diacetylchitobiose-specific phosphotransferase enzyme IIB component {ECO:0000303|PubMed 2092358} # BioGrid 4260316 10 # CATALYTIC ACTIVITY PTQB_ECOLI [Protein]-N(pi)-phospho-L-histidine + N,N'- diacetylchitobiose(Side 1) = [protein]-L-histidine + N,N'- diacetylchitobiose 6'-phosphate(Side 2). {ECO 0000269|PubMed 10913117, ECO 0000269|PubMed 10913119}. # CAUTION Was originally (PubMed:2092358) characterized as part of a cryptic cel operon for a cellobiose degradation system. The Cel+ phenotype is due to mutations making expression chitobiose- independent and altering the substrate specificity. {ECO 0000305|PubMed:2092358}. # DOMAIN PTQB_ECOLI The PTS EIIB type-3 domain is phosphorylated by phospho- EIIA on a cysteinyl residue. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the PTS EIIC type-3 domain. {ECO 0000255|PROSITE- ProRule PRU00423}. # EcoGene EG10140 chbB # FUNCTION PTQB_ECOLI The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ChbABC PTS system is involved in the transport of the chitin disaccharide N,N'-diacetylchitobiose (GlcNAc2) (PubMed 10913117). Also able to use N,N',N''-triacetyl chitotriose (GlcNAc3) (PubMed 10913117, PubMed 10913119). {ECO 0000269|PubMed 10913117, ECO 0000269|PubMed 10913119, ECO 0000305|PubMed 2092358}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008982 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:InterPro. # GO_function GO:0016301 kinase activity; IEA:UniProtKB-KW. # GO_function GO:0090566 protein-phosphocysteine-N,N'-diacetylchitobiose phosphotransferase system transporter activity; IDA:EcoCyc. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IDA:EcoCyc. # GO_process GO:1902815 N,N'-diacetylchitobiose import; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # INDUCTION By GlcNAc2, GlcNAc3 and beta-N,N'-diacetylchitobiose (Me-TCB). {ECO:0000269|PubMed 10913117}. # InterPro IPR003501 PTS_EIIB_2/3 # InterPro IPR013012 PTS_EIIB_3 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00275 PTS system, cellobiose-specific II component # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02060 Phosphotransferase system (PTS) # Organism PTQB_ECOLI Escherichia coli (strain K12) # PATRIC 32118785 VBIEscCol129921_1810 # PDB 1E2B NMR; -; A=1-106 # PDB 1H9C NMR; -; A=1-106 # PDB 1IIB X-ray; 1.80 A; A/B=1-106 # PDB 2WWV NMR; -; D=3-105 # PDB 2WY2 NMR; -; D=3-105 # PIR S10870 S10870 # PROSITE PS51100 PTS_EIIB_TYPE_3 # Pfam PF02302 PTS_IIB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PTS system N,N'-diacetylchitobiose-specific EIIB component {ECO:0000303|PubMed 2092358} # RefSeq NP_416252 NC_000913.3 # RefSeq WP_000412169 NZ_LN832404.1 # SIMILARITY Contains 1 PTS EIIB type-3 domain. {ECO:0000255|PROSITE-ProRule PRU00423}. # SUBCELLULAR LOCATION PTQB_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT PTQB_ECOLI Forms a complex with ChbA (EIIA) (PubMed 10913119, PubMed 10913122, PubMed 19959833). ChbB is a monomer in both its unphosphorylated and phosphorylated forms (PubMed 10913122). {ECO 0000269|PubMed 10913119, ECO 0000269|PubMed 10913122, ECO 0000269|PubMed 19959833}. # SUPFAM SSF52794 SSF52794 # TCDB 4.A.3.2 the pts lactose-n,n'-diacetylchitobiose-Beta-glucoside (lac) family # TIGRFAMs TIGR00853 pts-lac # eggNOG COG1440 LUCA # eggNOG ENOG4105VZJ Bacteria BLAST swissprot:PTQB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTQB_ECOLI BioCyc ECOL316407:JW1727-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1727-MONOMER BioCyc EcoCyc:CELA-MONOMER http://biocyc.org/getid?id=EcoCyc:CELA-MONOMER BioCyc MetaCyc:CELA-MONOMER http://biocyc.org/getid?id=MetaCyc:CELA-MONOMER COG COG1440 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1440 DOI 10.1002/pro.5560030212 http://dx.doi.org/10.1002/pro.5560030212 DOI 10.1002/pro.5560060205 http://dx.doi.org/10.1002/pro.5560060205 DOI 10.1006/jmbi.2001.4623 http://dx.doi.org/10.1006/jmbi.2001.4623 DOI 10.1016/0923-2508(90)90079-6 http://dx.doi.org/10.1016/0923-2508(90)90079-6 DOI 10.1016/S0969-2126(97)00180-9 http://dx.doi.org/10.1016/S0969-2126(97)00180-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.94.26.14367 http://dx.doi.org/10.1073/pnas.94.26.14367 DOI 10.1074/jbc.M001043200 http://dx.doi.org/10.1074/jbc.M001043200 DOI 10.1074/jbc.M001045200 http://dx.doi.org/10.1074/jbc.M001045200 DOI 10.1074/jbc.M001717200 http://dx.doi.org/10.1074/jbc.M001717200 DOI 10.1074/jbc.M109.080937 http://dx.doi.org/10.1074/jbc.M109.080937 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.196 {ECO:0000269|PubMed:10913117, ECO:0000269|PubMed:10913119} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.196 {ECO:0000269|PubMed:10913117, ECO:0000269|PubMed:10913119} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X52890 http://www.ebi.ac.uk/ena/data/view/X52890 ENZYME 2.7.1.196 {ECO:0000269|PubMed:10913117, ECO:0000269|PubMed:10913119} http://enzyme.expasy.org/EC/2.7.1.196 {ECO:0000269|PubMed:10913117, ECO:0000269|PubMed:10913119} EchoBASE EB0138 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0138 EcoGene EG10140 http://www.ecogene.org/geneInfo.php?eg_id=EG10140 EnsemblBacteria AAC74808 http://www.ensemblgenomes.org/id/AAC74808 EnsemblBacteria AAC74808 http://www.ensemblgenomes.org/id/AAC74808 EnsemblBacteria BAA15519 http://www.ensemblgenomes.org/id/BAA15519 EnsemblBacteria BAA15519 http://www.ensemblgenomes.org/id/BAA15519 EnsemblBacteria BAA15519 http://www.ensemblgenomes.org/id/BAA15519 EnsemblBacteria b1738 http://www.ensemblgenomes.org/id/b1738 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008982 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008982 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_function GO:0090566 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090566 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GO_process GO:1902815 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902815 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 945339 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945339 HOGENOM HOG000224223 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000224223&db=HOGENOM6 InParanoid P69795 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P69795 IntAct P69795 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69795* IntEnz 2.7.1.196 {ECO:0000269|PubMed:10913117, ECO:0000269|PubMed:10913119} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.196 {ECO:0000269|PubMed:10913117, ECO:0000269|PubMed:10913119} InterPro IPR003501 http://www.ebi.ac.uk/interpro/entry/IPR003501 InterPro IPR013012 http://www.ebi.ac.uk/interpro/entry/IPR013012 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1727 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1727 KEGG_Gene eco:b1738 http://www.genome.jp/dbget-bin/www_bget?eco:b1738 KEGG_Orthology KO:K02760 http://www.genome.jp/dbget-bin/www_bget?KO:K02760 KEGG_Pathway ko02060 http://www.genome.jp/kegg-bin/show_pathway?ko02060 OMA YKIWAVS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YKIWAVS PDB 1E2B http://www.ebi.ac.uk/pdbe-srv/view/entry/1E2B PDB 1H9C http://www.ebi.ac.uk/pdbe-srv/view/entry/1H9C PDB 1IIB http://www.ebi.ac.uk/pdbe-srv/view/entry/1IIB PDB 2WWV http://www.ebi.ac.uk/pdbe-srv/view/entry/2WWV PDB 2WY2 http://www.ebi.ac.uk/pdbe-srv/view/entry/2WY2 PDBsum 1E2B http://www.ebi.ac.uk/pdbsum/1E2B PDBsum 1H9C http://www.ebi.ac.uk/pdbsum/1H9C PDBsum 1IIB http://www.ebi.ac.uk/pdbsum/1IIB PDBsum 2WWV http://www.ebi.ac.uk/pdbsum/2WWV PDBsum 2WY2 http://www.ebi.ac.uk/pdbsum/2WY2 PROSITE PS51100 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51100 PSORT swissprot:PTQB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTQB_ECOLI PSORT-B swissprot:PTQB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTQB_ECOLI PSORT2 swissprot:PTQB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTQB_ECOLI Pfam PF02302 http://pfam.xfam.org/family/PF02302 Phobius swissprot:PTQB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTQB_ECOLI PhylomeDB P69795 http://phylomedb.org/?seqid=P69795 ProteinModelPortal P69795 http://www.proteinmodelportal.org/query/uniprot/P69795 PubMed 10913117 http://www.ncbi.nlm.nih.gov/pubmed/10913117 PubMed 10913119 http://www.ncbi.nlm.nih.gov/pubmed/10913119 PubMed 10913122 http://www.ncbi.nlm.nih.gov/pubmed/10913122 PubMed 11352587 http://www.ncbi.nlm.nih.gov/pubmed/11352587 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19959833 http://www.ncbi.nlm.nih.gov/pubmed/19959833 PubMed 2092358 http://www.ncbi.nlm.nih.gov/pubmed/2092358 PubMed 2179047 http://www.ncbi.nlm.nih.gov/pubmed/2179047 PubMed 8003964 http://www.ncbi.nlm.nih.gov/pubmed/8003964 PubMed 9032081 http://www.ncbi.nlm.nih.gov/pubmed/9032081 PubMed 9041631 http://www.ncbi.nlm.nih.gov/pubmed/9041631 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9405618 http://www.ncbi.nlm.nih.gov/pubmed/9405618 RefSeq NP_416252 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416252 RefSeq WP_000412169 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000412169 SMR P69795 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69795 STRING 511145.b1738 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1738&targetmode=cogs STRING COG1440 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1440&targetmode=cogs SUPFAM SSF52794 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52794 TCDB 4.A.3.2 http://www.tcdb.org/search/result.php?tc=4.A.3.2 TIGRFAMs TIGR00853 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00853 UniProtKB PTQB_ECOLI http://www.uniprot.org/uniprot/PTQB_ECOLI UniProtKB-AC P69795 http://www.uniprot.org/uniprot/P69795 charge swissprot:PTQB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTQB_ECOLI eggNOG COG1440 http://eggnogapi.embl.de/nog_data/html/tree/COG1440 eggNOG ENOG4105VZJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VZJ epestfind swissprot:PTQB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTQB_ECOLI garnier swissprot:PTQB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTQB_ECOLI helixturnhelix swissprot:PTQB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTQB_ECOLI hmoment swissprot:PTQB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTQB_ECOLI iep swissprot:PTQB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTQB_ECOLI inforesidue swissprot:PTQB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTQB_ECOLI octanol swissprot:PTQB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTQB_ECOLI pepcoil swissprot:PTQB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTQB_ECOLI pepdigest swissprot:PTQB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTQB_ECOLI pepinfo swissprot:PTQB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTQB_ECOLI pepnet swissprot:PTQB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTQB_ECOLI pepstats swissprot:PTQB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTQB_ECOLI pepwheel swissprot:PTQB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTQB_ECOLI pepwindow swissprot:PTQB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTQB_ECOLI sigcleave swissprot:PTQB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTQB_ECOLI ## Database ID URL or Descriptions # EcoGene EG14174 yffM # Organism YFFM_ECOLI Escherichia coli (strain K12) # PATRIC 32120271 VBIEscCol129921_2538 # PIR C65019 C65019 # Proteomes UP000000625 Chromosome # RecName YFFM_ECOLI Uncharacterized protein YffM # RefSeq NP_416939 NC_000913.3 BLAST swissprot:YFFM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFFM_ECOLI BioCyc EcoCyc:G7274-MONOMER http://biocyc.org/getid?id=EcoCyc:G7274-MONOMER DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3926 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3926 EcoGene EG14174 http://www.ecogene.org/geneInfo.php?eg_id=EG14174 EnsemblBacteria AAC75497 http://www.ensemblgenomes.org/id/AAC75497 EnsemblBacteria AAC75497 http://www.ensemblgenomes.org/id/AAC75497 EnsemblBacteria b2444 http://www.ensemblgenomes.org/id/b2444 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946921 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946921 KEGG_Gene eco:b2444 http://www.genome.jp/dbget-bin/www_bget?eco:b2444 PSORT swissprot:YFFM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFFM_ECOLI PSORT-B swissprot:YFFM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFFM_ECOLI PSORT2 swissprot:YFFM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFFM_ECOLI Phobius swissprot:YFFM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFFM_ECOLI ProteinModelPortal P76544 http://www.proteinmodelportal.org/query/uniprot/P76544 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416939 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416939 STRING 511145.b2444 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2444&targetmode=cogs UniProtKB YFFM_ECOLI http://www.uniprot.org/uniprot/YFFM_ECOLI UniProtKB-AC P76544 http://www.uniprot.org/uniprot/P76544 charge swissprot:YFFM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFFM_ECOLI epestfind swissprot:YFFM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFFM_ECOLI garnier swissprot:YFFM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFFM_ECOLI helixturnhelix swissprot:YFFM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFFM_ECOLI hmoment swissprot:YFFM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFFM_ECOLI iep swissprot:YFFM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFFM_ECOLI inforesidue swissprot:YFFM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFFM_ECOLI octanol swissprot:YFFM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFFM_ECOLI pepcoil swissprot:YFFM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFFM_ECOLI pepdigest swissprot:YFFM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFFM_ECOLI pepinfo swissprot:YFFM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFFM_ECOLI pepnet swissprot:YFFM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFFM_ECOLI pepstats swissprot:YFFM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFFM_ECOLI pepwheel swissprot:YFFM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFFM_ECOLI pepwindow swissprot:YFFM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFFM_ECOLI sigcleave swissprot:YFFM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFFM_ECOLI ## Database ID URL or Descriptions # AltName ENTH_ECOLI p15 # AltName Enterobactin synthase component H {ECO:0000255|HAMAP-Rule MF_00907} # BIOPHYSICOCHEMICAL PROPERTIES ENTH_ECOLI Kinetic parameters KM=16 uM for 2,3-DHB-EntB {ECO 0000269|PubMed 19119850}; KM=116 uM for 2,3-DHB-EntB {ECO 0000269|PubMed 19193103}; KM=21 uM for 4-hydroxybenzoyl-CoA {ECO 0000269|PubMed 19119850}; KM=190 uM for 4-hydroxybenzoyl-CoA {ECO 0000269|PubMed 19193103}; KM=25 uM for 2,4-DHB-EntB {ECO 0000269|PubMed 19119850}; KM=32 uM for lauroyl-EntB {ECO 0000269|PubMed 19119850}; KM=35 uM for 3-hydroxybenzoyl-CoA {ECO 0000269|PubMed 19119850}; KM=265 uM for 3-hydroxybenzoyl-CoA {ECO 0000269|PubMed 19193103}; KM=37 uM for 3-HPA-CoA {ECO 0000269|PubMed 19119850}; KM=45 uM for lauroyl-CoA {ECO 0000269|PubMed 19119850}; KM=49 uM for decanoyl-CoA {ECO 0000269|PubMed 19119850}; KM=55 uM for palmitoyl-CoA {ECO 0000269|PubMed 19119850}; KM=4.25 uM for palmitoyl-CoA {ECO 0000269|PubMed 19193103}; KM=161 uM for 2,3-dihydroxybenzoyl-CoA {ECO 0000269|PubMed 19193103}; KM=176 uM for salicylyl-CoA {ECO 0000269|PubMed 19193103}; KM=212 uM for 3,4-dihydroxybenzoyl-CoA {ECO 0000269|PubMed 19193103}; KM=219 uM for 2,4-dihydroxybenzoyl-CoA {ECO 0000269|PubMed 19193103}; KM=256 uM for 3,5-dihydroxybenzoyl-CoA {ECO 0000269|PubMed 19193103}; KM=272 uM for salicylyl-EntB {ECO 0000269|PubMed 19193103}; KM=350 uM for hexanoyl-CoA {ECO 0000269|PubMed 19119850}; KM=400 uM for propionyl-CoA {ECO 0000269|PubMed 19119850}; KM=475 uM for benzoyl-CoA {ECO 0000269|PubMed 19193103}; KM=800 uM for acetyl-CoA {ECO 0000269|PubMed 19119850}; # BRENDA 3.1.2 2026 # BioGrid 4260982 15 # EcoGene EG11105 entH # FUNCTION ENTH_ECOLI Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules. Displays esterase activity toward a wide range of substrates, including acyl-CoAs and aryl-CoAs. {ECO 0000269|PubMed 15808744, ECO 0000269|PubMed 17675380, ECO 0000269|PubMed 19119850, ECO 0000269|PubMed 19193103, ECO 0000269|PubMed 24992697}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0016289 CoA hydrolase activity; IDA:EcoCyc. # GO_function GO:0016788 hydrolase activity, acting on ester bonds; IDA:EcoCyc. # GO_function GO:0016790 thiolester hydrolase activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0009239 enterobactin biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0019748 secondary metabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.10.129.10 -; 1. # HAMAP MF_00907 Thioesterase_EntH # INDUCTION Induced by iron starvation. {ECO:0000269|PubMed 17675380}. # INTERACTION ENTH_ECOLI P0ADI4 entB; NbExp=3; IntAct=EBI-1118982, EBI-547993; # IntAct P0A8Y8 2 # InterPro IPR003736 PAAI_dom # InterPro IPR006683 Thioestr_dom # InterPro IPR026576 Thioesterase_EntH # InterPro IPR029069 HotDog_dom # KEGG_Brite ko01000 Enzymes # Organism ENTH_ECOLI Escherichia coli (strain K12) # PATHWAY ENTH_ECOLI Siderophore biosynthesis; enterobactin biosynthesis. {ECO 0000255|HAMAP-Rule MF_00907, ECO 0000269|PubMed 17675380}. # PATRIC 32116370 VBIEscCol129921_0625 # PDB 1VH9 X-ray; 2.15 A; A/B=2-137 # PDB 4K4C X-ray; 1.85 A; A/B/C/D=1-137 # PDB 4K4D X-ray; 2.17 A; A/B=1-137 # PIR B91904 Q3ECEA # Pfam PF03061 4HBT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Proofreading thioesterase EntH {ECO:0000255|HAMAP-Rule MF_00907} # RefSeq NP_415129 NC_000913.3 # RefSeq WP_000637953 NZ_LN832404.1 # SIMILARITY Belongs to the thioesterase PaaI family. {ECO:0000255|HAMAP-Rule MF_00907}. # SUBCELLULAR LOCATION ENTH_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00907, ECO 0000269|PubMed 17675380}. # SUBUNIT ENTH_ECOLI Homotetramer. Dimer of dimers. Interacts specifically with the aryl carrier protein (ArCP) domain of EntB. {ECO 0000255|HAMAP-Rule MF_00907, ECO 0000269|PubMed 17675380, ECO 0000269|PubMed 19193103, ECO 0000269|PubMed 25010423}. # SUPFAM SSF54637 SSF54637 # TIGRFAMs TIGR00369 unchar_dom_1 # eggNOG COG2050 LUCA # eggNOG ENOG4108TZA Bacteria BLAST swissprot:ENTH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ENTH_ECOLI BioCyc ECOL316407:JW0589-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0589-MONOMER BioCyc EcoCyc:EG11105-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11105-MONOMER BioCyc MetaCyc:EG11105-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11105-MONOMER DIP DIP-11343N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11343N DOI 10.1016/j.fmrre.2004.12.006 http://dx.doi.org/10.1016/j.fmrre.2004.12.006 DOI 10.1021/bi500333m http://dx.doi.org/10.1021/bi500333m DOI 10.1021/bi500334v http://dx.doi.org/10.1021/bi500334v DOI 10.1021/bi802165x http://dx.doi.org/10.1021/bi802165x DOI 10.1021/bi802207t http://dx.doi.org/10.1021/bi802207t DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00755-07 http://dx.doi.org/10.1128/JB.00755-07 EC_number EC:3.1.2.- {ECO:0000255|HAMAP-Rule:MF_00907} http://www.genome.jp/dbget-bin/www_bget?EC:3.1.2.- {ECO:0000255|HAMAP-Rule:MF_00907} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M24143 http://www.ebi.ac.uk/ena/data/view/M24143 EMBL M24148 http://www.ebi.ac.uk/ena/data/view/M24148 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 ENZYME 3.1.2.- {ECO:0000255|HAMAP-Rule:MF_00907} http://enzyme.expasy.org/EC/3.1.2.- {ECO:0000255|HAMAP-Rule:MF_00907} EchoBASE EB1097 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1097 EcoGene EG11105 http://www.ecogene.org/geneInfo.php?eg_id=EG11105 EnsemblBacteria AAC73698 http://www.ensemblgenomes.org/id/AAC73698 EnsemblBacteria AAC73698 http://www.ensemblgenomes.org/id/AAC73698 EnsemblBacteria BAE76352 http://www.ensemblgenomes.org/id/BAE76352 EnsemblBacteria BAE76352 http://www.ensemblgenomes.org/id/BAE76352 EnsemblBacteria BAE76352 http://www.ensemblgenomes.org/id/BAE76352 EnsemblBacteria b0597 http://www.ensemblgenomes.org/id/b0597 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0016289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016289 GO_function GO:0016788 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016788 GO_function GO:0016790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016790 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0009239 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009239 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0019748 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019748 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.10.129.10 http://www.cathdb.info/version/latest/superfamily/3.10.129.10 GeneID 945215 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945215 HAMAP MF_00907 http://hamap.expasy.org/unirule/MF_00907 HOGENOM HOG000066991 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000066991&db=HOGENOM6 InParanoid P0A8Y8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8Y8 IntAct P0A8Y8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8Y8* IntEnz 3.1.2.- {ECO:0000255|HAMAP-Rule:MF_00907} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.2.- {ECO:0000255|HAMAP-Rule:MF_00907} InterPro IPR003736 http://www.ebi.ac.uk/interpro/entry/IPR003736 InterPro IPR006683 http://www.ebi.ac.uk/interpro/entry/IPR006683 InterPro IPR026576 http://www.ebi.ac.uk/interpro/entry/IPR026576 InterPro IPR029069 http://www.ebi.ac.uk/interpro/entry/IPR029069 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0589 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0589 KEGG_Gene eco:b0597 http://www.genome.jp/dbget-bin/www_bget?eco:b0597 KEGG_Orthology KO:K01175 http://www.genome.jp/dbget-bin/www_bget?KO:K01175 OMA EVRGICQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EVRGICQ PDB 1VH9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1VH9 PDB 4K4C http://www.ebi.ac.uk/pdbe-srv/view/entry/4K4C PDB 4K4D http://www.ebi.ac.uk/pdbe-srv/view/entry/4K4D PDBsum 1VH9 http://www.ebi.ac.uk/pdbsum/1VH9 PDBsum 4K4C http://www.ebi.ac.uk/pdbsum/4K4C PDBsum 4K4D http://www.ebi.ac.uk/pdbsum/4K4D PSORT swissprot:ENTH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ENTH_ECOLI PSORT-B swissprot:ENTH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ENTH_ECOLI PSORT2 swissprot:ENTH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ENTH_ECOLI Pfam PF03061 http://pfam.xfam.org/family/PF03061 Phobius swissprot:ENTH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ENTH_ECOLI PhylomeDB P0A8Y8 http://phylomedb.org/?seqid=P0A8Y8 ProteinModelPortal P0A8Y8 http://www.proteinmodelportal.org/query/uniprot/P0A8Y8 PubMed 15808744 http://www.ncbi.nlm.nih.gov/pubmed/15808744 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17675380 http://www.ncbi.nlm.nih.gov/pubmed/17675380 PubMed 19119850 http://www.ncbi.nlm.nih.gov/pubmed/19119850 PubMed 19193103 http://www.ncbi.nlm.nih.gov/pubmed/19193103 PubMed 24992697 http://www.ncbi.nlm.nih.gov/pubmed/24992697 PubMed 25010423 http://www.ncbi.nlm.nih.gov/pubmed/25010423 PubMed 2521621 http://www.ncbi.nlm.nih.gov/pubmed/2521621 PubMed 2521622 http://www.ncbi.nlm.nih.gov/pubmed/2521622 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415129 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415129 RefSeq WP_000637953 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000637953 SMR P0A8Y8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8Y8 STRING 511145.b0597 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0597&targetmode=cogs SUPFAM SSF54637 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54637 TIGRFAMs TIGR00369 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00369 UniProtKB ENTH_ECOLI http://www.uniprot.org/uniprot/ENTH_ECOLI UniProtKB-AC P0A8Y8 http://www.uniprot.org/uniprot/P0A8Y8 charge swissprot:ENTH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ENTH_ECOLI eggNOG COG2050 http://eggnogapi.embl.de/nog_data/html/tree/COG2050 eggNOG ENOG4108TZA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108TZA epestfind swissprot:ENTH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ENTH_ECOLI garnier swissprot:ENTH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ENTH_ECOLI helixturnhelix swissprot:ENTH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ENTH_ECOLI hmoment swissprot:ENTH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ENTH_ECOLI iep swissprot:ENTH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ENTH_ECOLI inforesidue swissprot:ENTH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ENTH_ECOLI octanol swissprot:ENTH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ENTH_ECOLI pepcoil swissprot:ENTH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ENTH_ECOLI pepdigest swissprot:ENTH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ENTH_ECOLI pepinfo swissprot:ENTH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ENTH_ECOLI pepnet swissprot:ENTH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ENTH_ECOLI pepstats swissprot:ENTH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ENTH_ECOLI pepwheel swissprot:ENTH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ENTH_ECOLI pepwindow swissprot:ENTH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ENTH_ECOLI sigcleave swissprot:ENTH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ENTH_ECOLI ## Database ID URL or Descriptions # AltName RCLB_ECOLI Reactive chlorine resistance protein B # BioGrid 4259799 13 # DISRUPTION PHENOTYPE Mutants are more sensitive to HOCl treatment than wild-type cells. {ECO:0000269|PubMed 24078635}. # EcoGene EG14278 rclB # FUNCTION RCLB_ECOLI Probably involved in reactive chlorine species (RCS) stress resistance. {ECO 0000269|PubMed 24078635}. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_process GO:1901530 response to hypochlorite; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0006950 response to stress # Gene3D 3.30.1660.10 -; 1. # INDUCTION Induced by RclR in response to hypochlorous acid (HOCl). {ECO:0000269|PubMed 24078635}. # InterPro IPR010854 DUF1471 # InterPro IPR025543 Dodecin-like # Organism RCLB_ECOLI Escherichia coli (strain K12) # PATRIC 32115735 VBIEscCol129921_0310 # PIR G64756 G64756 # Pfam PF07338 DUF1471 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RCLB_ECOLI Uncharacterized protein RclB # RefSeq NP_414837 NC_000913.3 # RefSeq WP_000474084 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18030.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the BhsA/McbA family. {ECO 0000305}. # SUBCELLULAR LOCATION RCLB_ECOLI Periplasm {ECO 0000305}. # SUPFAM SSF159871 SSF159871 # eggNOG ENOG41066GK Bacteria # eggNOG ENOG410XU9X LUCA BLAST swissprot:RCLB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RCLB_ECOLI BioCyc ECOL316407:JW5039-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5039-MONOMER BioCyc EcoCyc:G6173-MONOMER http://biocyc.org/getid?id=EcoCyc:G6173-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M113.503516 http://dx.doi.org/10.1074/jbc.M113.503516 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB4026 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4026 EcoGene EG14278 http://www.ecogene.org/geneInfo.php?eg_id=EG14278 EnsemblBacteria AAC73406 http://www.ensemblgenomes.org/id/AAC73406 EnsemblBacteria AAC73406 http://www.ensemblgenomes.org/id/AAC73406 EnsemblBacteria BAE76087 http://www.ensemblgenomes.org/id/BAE76087 EnsemblBacteria BAE76087 http://www.ensemblgenomes.org/id/BAE76087 EnsemblBacteria BAE76087 http://www.ensemblgenomes.org/id/BAE76087 EnsemblBacteria b0303 http://www.ensemblgenomes.org/id/b0303 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_process GO:1901530 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901530 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.30.1660.10 http://www.cathdb.info/version/latest/superfamily/3.30.1660.10 GeneID 945658 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945658 HOGENOM HOG000009337 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009337&db=HOGENOM6 InterPro IPR010854 http://www.ebi.ac.uk/interpro/entry/IPR010854 InterPro IPR025543 http://www.ebi.ac.uk/interpro/entry/IPR025543 KEGG_Gene ecj:JW5039 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5039 KEGG_Gene eco:b0303 http://www.genome.jp/dbget-bin/www_bget?eco:b0303 OMA EHISVSA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EHISVSA PSORT swissprot:RCLB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RCLB_ECOLI PSORT-B swissprot:RCLB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RCLB_ECOLI PSORT2 swissprot:RCLB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RCLB_ECOLI Pfam PF07338 http://pfam.xfam.org/family/PF07338 Phobius swissprot:RCLB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RCLB_ECOLI ProteinModelPortal P75687 http://www.proteinmodelportal.org/query/uniprot/P75687 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 24078635 http://www.ncbi.nlm.nih.gov/pubmed/24078635 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414837 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414837 RefSeq WP_000474084 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000474084 STRING 511145.b0303 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0303&targetmode=cogs SUPFAM SSF159871 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF159871 UniProtKB RCLB_ECOLI http://www.uniprot.org/uniprot/RCLB_ECOLI UniProtKB-AC P75687 http://www.uniprot.org/uniprot/P75687 charge swissprot:RCLB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RCLB_ECOLI eggNOG ENOG41066GK http://eggnogapi.embl.de/nog_data/html/tree/ENOG41066GK eggNOG ENOG410XU9X http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XU9X epestfind swissprot:RCLB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RCLB_ECOLI garnier swissprot:RCLB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RCLB_ECOLI helixturnhelix swissprot:RCLB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RCLB_ECOLI hmoment swissprot:RCLB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RCLB_ECOLI iep swissprot:RCLB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RCLB_ECOLI inforesidue swissprot:RCLB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RCLB_ECOLI octanol swissprot:RCLB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RCLB_ECOLI pepcoil swissprot:RCLB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RCLB_ECOLI pepdigest swissprot:RCLB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RCLB_ECOLI pepinfo swissprot:RCLB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RCLB_ECOLI pepnet swissprot:RCLB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RCLB_ECOLI pepstats swissprot:RCLB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RCLB_ECOLI pepwheel swissprot:RCLB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RCLB_ECOLI pepwindow swissprot:RCLB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RCLB_ECOLI sigcleave swissprot:RCLB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RCLB_ECOLI ## Database ID URL or Descriptions # BioGrid 4263146 4 # EcoGene EG12905 yheU # Gene3D 1.10.10.610 -; 1. # HAMAP MF_00690 UPF0270 # IntAct P67624 7 # InterPro IPR010648 UPF0270 # Organism YHEU_ECOLI Escherichia coli (strain K12) # PATRIC 32122142 VBIEscCol129921_3448 # PIR E65129 E65129 # PIRSF PIRSF006169 UCP006169 # Pfam PF06794 UPF0270 # ProDom PD026997 UPF0270 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHEU_ECOLI UPF0270 protein YheU # RefSeq NP_417813 NC_000913.3 # RefSeq WP_000907085 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0270 family. {ECO 0000305}. # SUPFAM SSF118001 SSF118001 # eggNOG COG3089 LUCA # eggNOG ENOG4105YP7 Bacteria BLAST swissprot:YHEU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHEU_ECOLI BioCyc ECOL316407:JW3317-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3317-MONOMER BioCyc EcoCyc:G7719-MONOMER http://biocyc.org/getid?id=EcoCyc:G7719-MONOMER COG COG3089 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3089 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2742 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2742 EcoGene EG12905 http://www.ecogene.org/geneInfo.php?eg_id=EG12905 EnsemblBacteria AAC76379 http://www.ensemblgenomes.org/id/AAC76379 EnsemblBacteria AAC76379 http://www.ensemblgenomes.org/id/AAC76379 EnsemblBacteria BAE77936 http://www.ensemblgenomes.org/id/BAE77936 EnsemblBacteria BAE77936 http://www.ensemblgenomes.org/id/BAE77936 EnsemblBacteria BAE77936 http://www.ensemblgenomes.org/id/BAE77936 EnsemblBacteria b3354 http://www.ensemblgenomes.org/id/b3354 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 1.10.10.610 http://www.cathdb.info/version/latest/superfamily/1.10.10.610 GeneID 947863 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947863 HAMAP MF_00690 http://hamap.expasy.org/unirule/MF_00690 HOGENOM HOG000006551 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006551&db=HOGENOM6 InParanoid P67624 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P67624 IntAct P67624 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P67624* InterPro IPR010648 http://www.ebi.ac.uk/interpro/entry/IPR010648 KEGG_Gene ecj:JW3317 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3317 KEGG_Gene eco:b3354 http://www.genome.jp/dbget-bin/www_bget?eco:b3354 KEGG_Orthology KO:K09898 http://www.genome.jp/dbget-bin/www_bget?KO:K09898 OMA IMPRGQF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IMPRGQF PSORT swissprot:YHEU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHEU_ECOLI PSORT-B swissprot:YHEU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHEU_ECOLI PSORT2 swissprot:YHEU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHEU_ECOLI Pfam PF06794 http://pfam.xfam.org/family/PF06794 Phobius swissprot:YHEU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHEU_ECOLI ProteinModelPortal P67624 http://www.proteinmodelportal.org/query/uniprot/P67624 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417813 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417813 RefSeq WP_000907085 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000907085 SMR P67624 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P67624 STRING 511145.b3354 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3354&targetmode=cogs STRING COG3089 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3089&targetmode=cogs SUPFAM SSF118001 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF118001 UniProtKB YHEU_ECOLI http://www.uniprot.org/uniprot/YHEU_ECOLI UniProtKB-AC P67624 http://www.uniprot.org/uniprot/P67624 charge swissprot:YHEU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHEU_ECOLI eggNOG COG3089 http://eggnogapi.embl.de/nog_data/html/tree/COG3089 eggNOG ENOG4105YP7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105YP7 epestfind swissprot:YHEU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHEU_ECOLI garnier swissprot:YHEU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHEU_ECOLI helixturnhelix swissprot:YHEU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHEU_ECOLI hmoment swissprot:YHEU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHEU_ECOLI iep swissprot:YHEU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHEU_ECOLI inforesidue swissprot:YHEU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHEU_ECOLI octanol swissprot:YHEU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHEU_ECOLI pepcoil swissprot:YHEU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHEU_ECOLI pepdigest swissprot:YHEU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHEU_ECOLI pepinfo swissprot:YHEU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHEU_ECOLI pepnet swissprot:YHEU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHEU_ECOLI pepstats swissprot:YHEU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHEU_ECOLI pepwheel swissprot:YHEU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHEU_ECOLI pepwindow swissprot:YHEU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHEU_ECOLI sigcleave swissprot:YHEU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHEU_ECOLI ## Database ID URL or Descriptions # AltName PINH_ECOLI Putative DNA-invertase from prophage CP4-44 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG14310 pinH # GO_function GO:0000150 recombinase activity; IEA:UniProtKB-KW. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0015074 DNA integration; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # IntAct P76611 3 # InterPro IPR006119 Resolv_N # Organism PINH_ECOLI Escherichia coli (strain K12) # PROSITE PS51736 RECOMBINASES_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Putative protein PinH {ECO 0000305} # SIMILARITY Belongs to the site-specific recombinase resolvase family. {ECO 0000305}. # SIMILARITY Contains 1 resolvase/invertase-type recombinase catalytic domain. {ECO:0000255|PROSITE-ProRule PRU01072}. BLAST swissprot:PINH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PINH_ECOLI BioCyc EcoCyc:G7383-MONOMER http://biocyc.org/getid?id=EcoCyc:G7383-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14310 http://www.ecogene.org/geneInfo.php?eg_id=EG14310 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000150 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0015074 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015074 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 IntAct P76611 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76611* InterPro IPR006119 http://www.ebi.ac.uk/interpro/entry/IPR006119 OMA LGRSMWH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LGRSMWH PROSITE PS51736 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51736 PSORT swissprot:PINH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PINH_ECOLI PSORT-B swissprot:PINH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PINH_ECOLI PSORT2 swissprot:PINH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PINH_ECOLI Phobius swissprot:PINH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PINH_ECOLI ProteinModelPortal P76611 http://www.proteinmodelportal.org/query/uniprot/P76611 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 UniProtKB PINH_ECOLI http://www.uniprot.org/uniprot/PINH_ECOLI UniProtKB-AC P76611 http://www.uniprot.org/uniprot/P76611 charge swissprot:PINH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PINH_ECOLI epestfind swissprot:PINH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PINH_ECOLI garnier swissprot:PINH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PINH_ECOLI helixturnhelix swissprot:PINH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PINH_ECOLI hmoment swissprot:PINH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PINH_ECOLI iep swissprot:PINH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PINH_ECOLI inforesidue swissprot:PINH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PINH_ECOLI octanol swissprot:PINH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PINH_ECOLI pepcoil swissprot:PINH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PINH_ECOLI pepdigest swissprot:PINH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PINH_ECOLI pepinfo swissprot:PINH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PINH_ECOLI pepnet swissprot:PINH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PINH_ECOLI pepstats swissprot:PINH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PINH_ECOLI pepwheel swissprot:PINH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PINH_ECOLI pepwindow swissprot:PINH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PINH_ECOLI sigcleave swissprot:PINH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PINH_ECOLI ## Database ID URL or Descriptions # AltName PUR1_ECOLI Glutamine phosphoribosylpyrophosphate amidotransferase {ECO 0000255|HAMAP-Rule MF_01931, ECO 0000303|PubMed 372191} # BIOPHYSICOCHEMICAL PROPERTIES PUR1_ECOLI Kinetic parameters KM=0.067 mM for phosphoribosylpyrophosphate {ECO 0000269|PubMed 372191}; KM=1.7 mM for glutamine {ECO 0000269|PubMed 372191}; KM=8.8 mM for NH(3) {ECO 0000269|PubMed 372191}; # BRENDA 2.4.2.14 2026 # CATALYTIC ACTIVITY PUR1_ECOLI 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H(2)O. {ECO 0000255|HAMAP-Rule MF_01931, ECO 0000269|PubMed 372191}. # CDD cd06223 PRTases_typeI # COFACTOR PUR1_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_01931}; Note=Binds 1 Mg(2+) ion per subunit. {ECO 0000255|HAMAP- Rule MF_01931}; # ENZYME REGULATION Inhibited by iodoacetamide and by the glutamine analogs chloroketone and DON. {ECO:0000269|PubMed 372191}. # EcoGene EG10794 purF # FUNCTION PUR1_ECOLI Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. Can also use NH(3) in place of glutamine. {ECO 0000269|PubMed 372191}. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0004044 amidophosphoribosyltransferase activity; IDA:EcoliWiki. # GO_function GO:0016757 transferase activity, transferring glycosyl groups; IDA:EcoliWiki. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0006164 purine nucleotide biosynthetic process; IDA:EcoliWiki. # GO_process GO:0006189 'de novo' IMP biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0006541 glutamine metabolic process; IDA:EcoliWiki. # GO_process GO:0009113 purine nucleobase biosynthetic process; IEA:InterPro. # GO_process GO:0009116 nucleoside metabolic process; IEA:InterPro. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.2020 -; 1. # Gene3D 3.60.20.10 -; 1. # HAMAP MF_01931 PurF # InterPro IPR000836 PRibTrfase_dom # InterPro IPR005854 PurF # InterPro IPR017932 GATase_2_dom # InterPro IPR029055 Ntn_hydrolases_N # InterPro IPR029057 PRTase-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00250 Alanine, aspartate and glutamate metabolism # Organism PUR1_ECOLI Escherichia coli (strain K12) # PATHWAY PUR1_ECOLI Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D- ribose 1-diphosphate step 1/2. {ECO 0000255|HAMAP-Rule MF_01931, ECO 0000269|PubMed 372191}. # PATRIC 32119995 VBIEscCol129921_2407 # PDB 1ECB X-ray; 2.70 A; A/B/C/D=2-505 # PDB 1ECC X-ray; 2.40 A; A/B=2-505 # PDB 1ECF X-ray; 2.00 A; A/B=2-505 # PDB 1ECG X-ray; 2.30 A; A/B=2-505 # PDB 1ECJ X-ray; 2.50 A; A/B/C/D=2-505 # PIR F65003 XQEC # PIRSF PIRSF000485 Amd_phspho_trans # PROSITE PS00103 PUR_PYR_PR_TRANSFER # PROSITE PS51278 GATASE_TYPE_2 # Pfam PF00156 Pribosyltran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PUR1_ECOLI Amidophosphoribosyltransferase {ECO 0000255|HAMAP-Rule MF_01931, ECO 0000303|PubMed 6443594} # RefSeq NP_416815 NC_000913.3 # RefSeq WP_000334220 NZ_LN832404.1 # SIMILARITY Contains 1 glutamine amidotransferase type-2 domain. {ECO:0000255|HAMAP-Rule MF_01931}. # SIMILARITY In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. {ECO:0000255|HAMAP-Rule MF_01931, ECO:0000305}. # SUBUNIT Homotetramer. {ECO:0000269|PubMed 9514258}. # SUPFAM SSF53271 SSF53271 # SUPFAM SSF56235 SSF56235 # TIGRFAMs TIGR01134 purF # UniPathway UPA00074 UER00124 # eggNOG COG0034 LUCA # eggNOG ENOG4105CBA Bacteria BLAST swissprot:PUR1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PUR1_ECOLI BioCyc ECOL316407:JW2309-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2309-MONOMER BioCyc EcoCyc:PRPPAMIDOTRANS-MONOMER http://biocyc.org/getid?id=EcoCyc:PRPPAMIDOTRANS-MONOMER BioCyc MetaCyc:PRPPAMIDOTRANS-MONOMER http://biocyc.org/getid?id=MetaCyc:PRPPAMIDOTRANS-MONOMER COG COG0034 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0034 DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/pro.5560070104 http://dx.doi.org/10.1002/pro.5560070104 DOI 10.1016/0065-2571(83)90016-X http://dx.doi.org/10.1016/0065-2571(83)90016-X DOI 10.1021/bi9714114 http://dx.doi.org/10.1021/bi9714114 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/nar/16.17.8717 http://dx.doi.org/10.1093/nar/16.17.8717 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DisProt DP00578 http://www.disprot.org/protein.php?id=DP00578 EC_number EC:2.4.2.14 {ECO:0000255|HAMAP-Rule:MF_01931, ECO:0000269|PubMed:372191} http://www.genome.jp/dbget-bin/www_bget?EC:2.4.2.14 {ECO:0000255|HAMAP-Rule:MF_01931, ECO:0000269|PubMed:372191} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01666 http://www.ebi.ac.uk/ena/data/view/J01666 EMBL M26893 http://www.ebi.ac.uk/ena/data/view/M26893 EMBL M68934 http://www.ebi.ac.uk/ena/data/view/M68934 EMBL M68935 http://www.ebi.ac.uk/ena/data/view/M68935 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00322 http://www.ebi.ac.uk/ena/data/view/V00322 EMBL X12423 http://www.ebi.ac.uk/ena/data/view/X12423 ENZYME 2.4.2.14 {ECO:0000255|HAMAP-Rule:MF_01931, ECO:0000269|PubMed:372191} http://enzyme.expasy.org/EC/2.4.2.14 {ECO:0000255|HAMAP-Rule:MF_01931, ECO:0000269|PubMed:372191} EchoBASE EB0787 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0787 EcoGene EG10794 http://www.ecogene.org/geneInfo.php?eg_id=EG10794 EnsemblBacteria AAC75372 http://www.ensemblgenomes.org/id/AAC75372 EnsemblBacteria AAC75372 http://www.ensemblgenomes.org/id/AAC75372 EnsemblBacteria BAA16158 http://www.ensemblgenomes.org/id/BAA16158 EnsemblBacteria BAA16158 http://www.ensemblgenomes.org/id/BAA16158 EnsemblBacteria BAA16158 http://www.ensemblgenomes.org/id/BAA16158 EnsemblBacteria b2312 http://www.ensemblgenomes.org/id/b2312 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0004044 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004044 GO_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0006164 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006164 GO_process GO:0006189 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006189 GO_process GO:0006541 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006541 GO_process GO:0009113 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009113 GO_process GO:0009116 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009116 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.2020 http://www.cathdb.info/version/latest/superfamily/3.40.50.2020 Gene3D 3.60.20.10 http://www.cathdb.info/version/latest/superfamily/3.60.20.10 GeneID 946794 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946794 HAMAP MF_01931 http://hamap.expasy.org/unirule/MF_01931 InParanoid P0AG16 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AG16 IntEnz 2.4.2.14 {ECO:0000255|HAMAP-Rule:MF_01931, ECO:0000269|PubMed:372191} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.2.14 {ECO:0000255|HAMAP-Rule:MF_01931, ECO:0000269|PubMed:372191} InterPro IPR000836 http://www.ebi.ac.uk/interpro/entry/IPR000836 InterPro IPR005854 http://www.ebi.ac.uk/interpro/entry/IPR005854 InterPro IPR017932 http://www.ebi.ac.uk/interpro/entry/IPR017932 InterPro IPR029055 http://www.ebi.ac.uk/interpro/entry/IPR029055 InterPro IPR029057 http://www.ebi.ac.uk/interpro/entry/IPR029057 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW2309 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2309 KEGG_Gene eco:b2312 http://www.genome.jp/dbget-bin/www_bget?eco:b2312 KEGG_Orthology KO:K00764 http://www.genome.jp/dbget-bin/www_bget?KO:K00764 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00250 http://www.genome.jp/kegg-bin/show_pathway?ko00250 KEGG_Reaction rn:R01072 http://www.genome.jp/dbget-bin/www_bget?rn:R01072 OMA AARVHMG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AARVHMG PDB 1ECB http://www.ebi.ac.uk/pdbe-srv/view/entry/1ECB PDB 1ECC http://www.ebi.ac.uk/pdbe-srv/view/entry/1ECC PDB 1ECF http://www.ebi.ac.uk/pdbe-srv/view/entry/1ECF PDB 1ECG http://www.ebi.ac.uk/pdbe-srv/view/entry/1ECG PDB 1ECJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1ECJ PDBsum 1ECB http://www.ebi.ac.uk/pdbsum/1ECB PDBsum 1ECC http://www.ebi.ac.uk/pdbsum/1ECC PDBsum 1ECF http://www.ebi.ac.uk/pdbsum/1ECF PDBsum 1ECG http://www.ebi.ac.uk/pdbsum/1ECG PDBsum 1ECJ http://www.ebi.ac.uk/pdbsum/1ECJ PROSITE PS00103 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00103 PROSITE PS51278 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51278 PSORT swissprot:PUR1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PUR1_ECOLI PSORT-B swissprot:PUR1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PUR1_ECOLI PSORT2 swissprot:PUR1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PUR1_ECOLI Pfam PF00156 http://pfam.xfam.org/family/PF00156 Phobius swissprot:PUR1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PUR1_ECOLI PhylomeDB P0AG16 http://phylomedb.org/?seqid=P0AG16 ProteinModelPortal P0AG16 http://www.proteinmodelportal.org/query/uniprot/P0AG16 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3040734 http://www.ncbi.nlm.nih.gov/pubmed/3040734 PubMed 3047685 http://www.ncbi.nlm.nih.gov/pubmed/3047685 PubMed 372191 http://www.ncbi.nlm.nih.gov/pubmed/372191 PubMed 6277938 http://www.ncbi.nlm.nih.gov/pubmed/6277938 PubMed 6443594 http://www.ncbi.nlm.nih.gov/pubmed/6443594 PubMed 7037784 http://www.ncbi.nlm.nih.gov/pubmed/7037784 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9333323 http://www.ncbi.nlm.nih.gov/pubmed/9333323 PubMed 9514258 http://www.ncbi.nlm.nih.gov/pubmed/9514258 RefSeq NP_416815 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416815 RefSeq WP_000334220 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000334220 SMR P0AG16 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AG16 STRING 511145.b2312 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2312&targetmode=cogs STRING COG0034 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0034&targetmode=cogs SUPFAM SSF53271 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53271 SUPFAM SSF56235 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56235 TIGRFAMs TIGR01134 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01134 UniProtKB PUR1_ECOLI http://www.uniprot.org/uniprot/PUR1_ECOLI UniProtKB-AC P0AG16 http://www.uniprot.org/uniprot/P0AG16 charge swissprot:PUR1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PUR1_ECOLI eggNOG COG0034 http://eggnogapi.embl.de/nog_data/html/tree/COG0034 eggNOG ENOG4105CBA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CBA epestfind swissprot:PUR1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PUR1_ECOLI garnier swissprot:PUR1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PUR1_ECOLI helixturnhelix swissprot:PUR1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PUR1_ECOLI hmoment swissprot:PUR1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PUR1_ECOLI iep swissprot:PUR1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PUR1_ECOLI inforesidue swissprot:PUR1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PUR1_ECOLI octanol swissprot:PUR1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PUR1_ECOLI pepcoil swissprot:PUR1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PUR1_ECOLI pepdigest swissprot:PUR1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PUR1_ECOLI pepinfo swissprot:PUR1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PUR1_ECOLI pepnet swissprot:PUR1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PUR1_ECOLI pepstats swissprot:PUR1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PUR1_ECOLI pepwheel swissprot:PUR1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PUR1_ECOLI pepwindow swissprot:PUR1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PUR1_ECOLI sigcleave swissprot:PUR1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PUR1_ECOLI ## Database ID URL or Descriptions # BioGrid 4260421 3 # CATALYTIC ACTIVITY HIS2_ECOLI 1-(5-phospho-beta-D-ribosyl)-AMP + H(2)O = 1- (5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D- ribosylamino)methylideneamino)imidazole-4-carboxamide. # CATALYTIC ACTIVITY HIS2_ECOLI 1-(5-phospho-beta-D-ribosyl)-ATP + H(2)O = 1- (5-phospho-beta-D-ribosyl)-AMP + diphosphate. # CDD cd11534 NTP-PPase_HisIE_like # EcoGene EG10451 hisI # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004635 phosphoribosyl-AMP cyclohydrolase activity; ISS:EcoCyc. # GO_function GO:0004636 phosphoribosyl-ATP diphosphatase activity; IGI:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0000105 histidine biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # HAMAP MF_01019 HisIE # HAMAP MF_01020 HisE # IntAct P06989 15 # InterPro IPR002496 PRib_AMP_CycHydrolase_dom # InterPro IPR008179 HisE # InterPro IPR021130 PRib-ATP_PPHydrolase-like # InterPro IPR023019 His_synth_HisIE # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00340 Histidine metabolism # Organism HIS2_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-histidine biosynthesis; L- histidine from 5-phospho-alpha-D-ribose 1-diphosphate step 2/9. # PATHWAY Amino-acid biosynthesis; L-histidine biosynthesis; L- histidine from 5-phospho-alpha-D-ribose 1-diphosphate step 3/9. # PATRIC 32119387 VBIEscCol129921_2103 # PIR JS0135 YNECHI # Pfam PF01502 PRA-CH # Pfam PF01503 PRA-PH # ProDom PD002610 PRA_CycHdrlase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HIS2_ECOLI Histidine biosynthesis bifunctional protein HisIE # RecName HIS2_ECOLI Histidine biosynthesis bifunctional protein HisIE # RecName HIS2_ECOLI Phosphoribosyl-AMP cyclohydrolase # RecName HIS2_ECOLI Phosphoribosyl-ATP pyrophosphatase # RefSeq NP_416530 NC_000913.3 # RefSeq WP_000954911 NZ_LN832404.1 # SIMILARITY In the C-terminal section; belongs to the PRA-PH family. {ECO 0000305}. # SIMILARITY In the N-terminal section; belongs to the PRA-CH family. {ECO 0000305}. # SUBCELLULAR LOCATION HIS2_ECOLI Cytoplasm. # TIGRFAMs TIGR03188 histidine_hisI # UniPathway UPA00031 UER00007 # UniPathway UPA00031 UER00008 # eggNOG COG0139 LUCA # eggNOG COG0140 LUCA # eggNOG ENOG4105K8F Bacteria BLAST swissprot:HIS2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HIS2_ECOLI BioCyc ECOL316407:JW2008-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2008-MONOMER BioCyc EcoCyc:HISTCYCLOPRATPPHOS http://biocyc.org/getid?id=EcoCyc:HISTCYCLOPRATPPHOS BioCyc MetaCyc:HISTCYCLOPRATPPHOS http://biocyc.org/getid?id=MetaCyc:HISTCYCLOPRATPPHOS COG COG0139 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0139 COG COG0140 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0140 DIP DIP-9907N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9907N DOI 10.1006/jmbi.1994.1384 http://dx.doi.org/10.1006/jmbi.1994.1384 DOI 10.1007/BF00422061 http://dx.doi.org/10.1007/BF00422061 DOI 10.1016/0022-2836(88)90194-5 http://dx.doi.org/10.1016/0022-2836(88)90194-5 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.5.4.19 http://www.genome.jp/dbget-bin/www_bget?EC:3.5.4.19 EC_number EC:3.6.1.31 http://www.genome.jp/dbget-bin/www_bget?EC:3.6.1.31 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D43637 http://www.ebi.ac.uk/ena/data/view/D43637 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U02072 http://www.ebi.ac.uk/ena/data/view/U02072 EMBL X03974 http://www.ebi.ac.uk/ena/data/view/X03974 EMBL X13462 http://www.ebi.ac.uk/ena/data/view/X13462 ENZYME 3.5.4.19 http://enzyme.expasy.org/EC/3.5.4.19 ENZYME 3.6.1.31 http://enzyme.expasy.org/EC/3.6.1.31 EchoBASE EB0446 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0446 EcoGene EG10451 http://www.ecogene.org/geneInfo.php?eg_id=EG10451 EnsemblBacteria AAC75087 http://www.ensemblgenomes.org/id/AAC75087 EnsemblBacteria AAC75087 http://www.ensemblgenomes.org/id/AAC75087 EnsemblBacteria BAA15858 http://www.ensemblgenomes.org/id/BAA15858 EnsemblBacteria BAA15858 http://www.ensemblgenomes.org/id/BAA15858 EnsemblBacteria BAA15858 http://www.ensemblgenomes.org/id/BAA15858 EnsemblBacteria b2026 http://www.ensemblgenomes.org/id/b2026 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004635 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004635 GO_function GO:0004636 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004636 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0000105 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000105 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 946515 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946515 HAMAP MF_01019 http://hamap.expasy.org/unirule/MF_01019 HAMAP MF_01020 http://hamap.expasy.org/unirule/MF_01020 HOGENOM HOG000277503 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000277503&db=HOGENOM6 InParanoid P06989 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P06989 IntAct P06989 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P06989* IntEnz 3.5.4.19 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.4.19 IntEnz 3.6.1.31 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.1.31 InterPro IPR002496 http://www.ebi.ac.uk/interpro/entry/IPR002496 InterPro IPR008179 http://www.ebi.ac.uk/interpro/entry/IPR008179 InterPro IPR021130 http://www.ebi.ac.uk/interpro/entry/IPR021130 InterPro IPR023019 http://www.ebi.ac.uk/interpro/entry/IPR023019 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2008 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2008 KEGG_Gene eco:b2026 http://www.genome.jp/dbget-bin/www_bget?eco:b2026 KEGG_Orthology KO:K11755 http://www.genome.jp/dbget-bin/www_bget?KO:K11755 KEGG_Pathway ko00340 http://www.genome.jp/kegg-bin/show_pathway?ko00340 KEGG_Reaction rn:R04035 http://www.genome.jp/dbget-bin/www_bget?rn:R04035 KEGG_Reaction rn:R04037 http://www.genome.jp/dbget-bin/www_bget?rn:R04037 OMA GTTTCWD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GTTTCWD PSORT swissprot:HIS2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HIS2_ECOLI PSORT-B swissprot:HIS2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HIS2_ECOLI PSORT2 swissprot:HIS2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HIS2_ECOLI Pfam PF01502 http://pfam.xfam.org/family/PF01502 Pfam PF01503 http://pfam.xfam.org/family/PF01503 Phobius swissprot:HIS2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HIS2_ECOLI PhylomeDB P06989 http://phylomedb.org/?seqid=P06989 ProteinModelPortal P06989 http://www.proteinmodelportal.org/query/uniprot/P06989 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3018428 http://www.ncbi.nlm.nih.gov/pubmed/3018428 PubMed 3062174 http://www.ncbi.nlm.nih.gov/pubmed/3062174 PubMed 7536735 http://www.ncbi.nlm.nih.gov/pubmed/7536735 PubMed 8201624 http://www.ncbi.nlm.nih.gov/pubmed/8201624 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416530 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416530 RefSeq WP_000954911 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000954911 SMR P06989 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P06989 STRING 511145.b2026 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2026&targetmode=cogs STRING COG0139 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0139&targetmode=cogs STRING COG0140 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0140&targetmode=cogs TIGRFAMs TIGR03188 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03188 UniProtKB HIS2_ECOLI http://www.uniprot.org/uniprot/HIS2_ECOLI UniProtKB-AC P06989 http://www.uniprot.org/uniprot/P06989 charge swissprot:HIS2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HIS2_ECOLI eggNOG COG0139 http://eggnogapi.embl.de/nog_data/html/tree/COG0139 eggNOG COG0140 http://eggnogapi.embl.de/nog_data/html/tree/COG0140 eggNOG ENOG4105K8F http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K8F epestfind swissprot:HIS2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HIS2_ECOLI garnier swissprot:HIS2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HIS2_ECOLI helixturnhelix swissprot:HIS2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HIS2_ECOLI hmoment swissprot:HIS2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HIS2_ECOLI iep swissprot:HIS2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HIS2_ECOLI inforesidue swissprot:HIS2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HIS2_ECOLI octanol swissprot:HIS2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HIS2_ECOLI pepcoil swissprot:HIS2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HIS2_ECOLI pepdigest swissprot:HIS2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HIS2_ECOLI pepinfo swissprot:HIS2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HIS2_ECOLI pepnet swissprot:HIS2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HIS2_ECOLI pepstats swissprot:HIS2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HIS2_ECOLI pepwheel swissprot:HIS2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HIS2_ECOLI pepwindow swissprot:HIS2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HIS2_ECOLI sigcleave swissprot:HIS2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HIS2_ECOLI ## Database ID URL or Descriptions # BioGrid 4259149 7 # COFACTOR YEAW_ECOLI Name=Fe cation; Xref=ChEBI CHEBI 24875; Evidence={ECO 0000305}; Note=Binds 1 Fe cation. {ECO 0000305}; # COFACTOR YEAW_ECOLI Name=[2Fe-2S] cluster; Xref=ChEBI CHEBI 49601; Evidence={ECO 0000305}; Note=Binds 1 [2Fe-2S] cluster. {ECO 0000305}; # EcoGene EG13509 yeaW # GO_function GO:0005506 iron ion binding; IEA:InterPro. # GO_function GO:0016708 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor; IEA:InterPro. # GO_function GO:0051537 2 iron, 2 sulfur cluster binding; IDA:EcoCyc. # GO_process GO:0019439 aromatic compound catabolic process; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # Gene3D 2.102.10.10 -; 1. # Gene3D 3.90.380.10 -; 1. # InterPro IPR001663 Rng_hydr_dOase-A # InterPro IPR015879 Ring_hydroxy_dOase_asu_C_dom # InterPro IPR015881 Ring-hydroxy_dOase_2Fe2S_BS # InterPro IPR017941 Rieske_2Fe-2S # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00363 Bisphenol degradation # KEGG_Pathway ko00624 Polycyclic aromatic hydrocarbon degradation # KEGG_Pathway ko00627 Aminobenzoate degradation # KEGG_Pathway ko00903 Limonene and pinene degradation # KEGG_Pathway ko00945 Stilbenoid, diarylheptanoid and gingerol biosynthesis # Organism YEAW_ECOLI Escherichia coli (strain K12) # PATRIC 32118921 VBIEscCol129921_1878 # PIR B64941 B64941 # PRINTS PR00090 RNGDIOXGNASE # PROSITE PS00570 RING_HYDROXYL_ALPHA # PROSITE PS51296 RIESKE # Pfam PF00355 Rieske # Pfam PF00848 Ring_hydroxyl_A # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEAW_ECOLI Putative dioxygenase subunit alpha YeaW # RefSeq NP_416316 NC_000913.3 # RefSeq WP_000067822 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial ring-hydroxylating dioxygenase alpha subunit family. {ECO 0000305}. # SIMILARITY Contains 1 Rieske domain. {ECO:0000255|PROSITE- ProRule PRU00628}. # SUBUNIT YEAW_ECOLI Probable heterodimer of YeaW and YeaX. # SUPFAM SSF50022 SSF50022 # eggNOG COG4638 LUCA # eggNOG ENOG4105DVW Bacteria BLAST swissprot:YEAW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEAW_ECOLI BioCyc ECOL316407:JW5294-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5294-MONOMER BioCyc EcoCyc:G6988-MONOMER http://biocyc.org/getid?id=EcoCyc:G6988-MONOMER COG COG2124 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2124 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.14.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.14.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.14.-.- http://enzyme.expasy.org/EC/1.14.-.- EchoBASE EB3282 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3282 EcoGene EG13509 http://www.ecogene.org/geneInfo.php?eg_id=EG13509 EnsemblBacteria AAC74872 http://www.ensemblgenomes.org/id/AAC74872 EnsemblBacteria AAC74872 http://www.ensemblgenomes.org/id/AAC74872 EnsemblBacteria BAA15597 http://www.ensemblgenomes.org/id/BAA15597 EnsemblBacteria BAA15597 http://www.ensemblgenomes.org/id/BAA15597 EnsemblBacteria BAA15597 http://www.ensemblgenomes.org/id/BAA15597 EnsemblBacteria b1802 http://www.ensemblgenomes.org/id/b1802 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0016708 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016708 GO_function GO:0051537 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051537 GO_process GO:0019439 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019439 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 2.102.10.10 http://www.cathdb.info/version/latest/superfamily/2.102.10.10 Gene3D 3.90.380.10 http://www.cathdb.info/version/latest/superfamily/3.90.380.10 GeneID 946325 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946325 HOGENOM HOG000248945 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000248945&db=HOGENOM6 InParanoid P0ABR7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABR7 IntEnz 1.14 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.14 InterPro IPR001663 http://www.ebi.ac.uk/interpro/entry/IPR001663 InterPro IPR015879 http://www.ebi.ac.uk/interpro/entry/IPR015879 InterPro IPR015881 http://www.ebi.ac.uk/interpro/entry/IPR015881 InterPro IPR017941 http://www.ebi.ac.uk/interpro/entry/IPR017941 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5294 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5294 KEGG_Gene eco:b1802 http://www.genome.jp/dbget-bin/www_bget?eco:b1802 KEGG_Orthology KO:K00517 http://www.genome.jp/dbget-bin/www_bget?KO:K00517 KEGG_Pathway ko00363 http://www.genome.jp/kegg-bin/show_pathway?ko00363 KEGG_Pathway ko00624 http://www.genome.jp/kegg-bin/show_pathway?ko00624 KEGG_Pathway ko00627 http://www.genome.jp/kegg-bin/show_pathway?ko00627 KEGG_Pathway ko00903 http://www.genome.jp/kegg-bin/show_pathway?ko00903 KEGG_Pathway ko00945 http://www.genome.jp/kegg-bin/show_pathway?ko00945 KEGG_Reaction rn:R04257 http://www.genome.jp/dbget-bin/www_bget?rn:R04257 KEGG_Reaction rn:R05265 http://www.genome.jp/dbget-bin/www_bget?rn:R05265 KEGG_Reaction rn:R06401 http://www.genome.jp/dbget-bin/www_bget?rn:R06401 KEGG_Reaction rn:R06404 http://www.genome.jp/dbget-bin/www_bget?rn:R06404 KEGG_Reaction rn:R06883 http://www.genome.jp/dbget-bin/www_bget?rn:R06883 KEGG_Reaction rn:R06888 http://www.genome.jp/dbget-bin/www_bget?rn:R06888 KEGG_Reaction rn:R07687 http://www.genome.jp/dbget-bin/www_bget?rn:R07687 KEGG_Reaction rn:R07697 http://www.genome.jp/dbget-bin/www_bget?rn:R07697 KEGG_Reaction rn:R07700 http://www.genome.jp/dbget-bin/www_bget?rn:R07700 KEGG_Reaction rn:R07706 http://www.genome.jp/dbget-bin/www_bget?rn:R07706 KEGG_Reaction rn:R09102 http://www.genome.jp/dbget-bin/www_bget?rn:R09102 KEGG_Reaction rn:R09104 http://www.genome.jp/dbget-bin/www_bget?rn:R09104 OMA QAVGHIW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QAVGHIW PRINTS PR00090 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00090 PROSITE PS00570 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00570 PROSITE PS51296 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51296 PSORT swissprot:YEAW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEAW_ECOLI PSORT-B swissprot:YEAW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEAW_ECOLI PSORT2 swissprot:YEAW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEAW_ECOLI Pfam PF00355 http://pfam.xfam.org/family/PF00355 Pfam PF00848 http://pfam.xfam.org/family/PF00848 Phobius swissprot:YEAW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEAW_ECOLI PhylomeDB P0ABR7 http://phylomedb.org/?seqid=P0ABR7 ProteinModelPortal P0ABR7 http://www.proteinmodelportal.org/query/uniprot/P0ABR7 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416316 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416316 RefSeq WP_000067822 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000067822 STRING 511145.b1802 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1802&targetmode=cogs STRING COG2124 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2124&targetmode=cogs SUPFAM SSF50022 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50022 UniProtKB YEAW_ECOLI http://www.uniprot.org/uniprot/YEAW_ECOLI UniProtKB-AC P0ABR7 http://www.uniprot.org/uniprot/P0ABR7 charge swissprot:YEAW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEAW_ECOLI eggNOG COG4638 http://eggnogapi.embl.de/nog_data/html/tree/COG4638 eggNOG ENOG4105DVW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DVW epestfind swissprot:YEAW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEAW_ECOLI garnier swissprot:YEAW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEAW_ECOLI helixturnhelix swissprot:YEAW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEAW_ECOLI hmoment swissprot:YEAW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEAW_ECOLI iep swissprot:YEAW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEAW_ECOLI inforesidue swissprot:YEAW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEAW_ECOLI octanol swissprot:YEAW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEAW_ECOLI pepcoil swissprot:YEAW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEAW_ECOLI pepdigest swissprot:YEAW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEAW_ECOLI pepinfo swissprot:YEAW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEAW_ECOLI pepnet swissprot:YEAW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEAW_ECOLI pepstats swissprot:YEAW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEAW_ECOLI pepwheel swissprot:YEAW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEAW_ECOLI pepwindow swissprot:YEAW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEAW_ECOLI sigcleave swissprot:YEAW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEAW_ECOLI ## Database ID URL or Descriptions # AltName 4-HB polyprenyltransferase {ECO:0000255|HAMAP-Rule MF_01635} # BioGrid 4259714 333 # CATALYTIC ACTIVITY 4-hydroxybenzoate + farnesylfarnesylgeraniol = 3-octaprenyl-4-hydroxybenzoate. {ECO:0000255|HAMAP-Rule MF_01635}. # COFACTOR UBIA_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_01635}; # EcoGene EG11370 ubiA # FUNCTION UBIA_ECOLI Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate. {ECO 0000255|HAMAP-Rule MF_01635, ECO 0000269|PubMed 7765507, ECO 0000269|PubMed 8155731}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0008412 4-hydroxybenzoate octaprenyltransferase activity; IDA:EcoliWiki. # GO_function GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups; IDA:EcoCyc. # GO_process GO:0006744 ubiquinone biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # HAMAP MF_01635 UbiA # InterPro IPR000537 UbiA_prenyltransferase # InterPro IPR006370 HB_polyprenyltransferase # InterPro IPR030470 UbiA_prenylTrfase_CS # InterPro IPR031103 HB_octoprenylTrfase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01006 Prenyltransferases # KEGG_Pathway ko00130 Ubiquinone and other terpenoid-quinone biosynthesis # Organism UBIA_ECOLI Escherichia coli (strain K12) # PATHWAY Cofactor biosynthesis; ubiquinone biosynthesis. {ECO:0000255|HAMAP-Rule MF_01635}. # PATRIC 32123617 VBIEscCol129921_4157 # PIR JC2316 JC2316 # PROSITE PS00943 UBIA # Pfam PF01040 UbiA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 4-hydroxybenzoate octaprenyltransferase {ECO:0000255|HAMAP-Rule MF_01635} # RefSeq NP_418464 NC_000913.3 # RefSeq WP_000455227 NZ_LN832404.1 # SIMILARITY Belongs to the UbiA prenyltransferase family. {ECO:0000255|HAMAP-Rule MF_01635, ECO:0000305}. # SUBCELLULAR LOCATION UBIA_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01635}; Multi-pass membrane protein {ECO 0000255|HAMAP- Rule MF_01635}. # TIGRFAMs TIGR01474 ubiA_proteo # eggNOG COG0382 LUCA # eggNOG ENOG4105C4G Bacteria BLAST swissprot:UBIA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UBIA_ECOLI BioCyc ECOL316407:JW4000-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4000-MONOMER BioCyc EcoCyc:4OHBENZOATE-OCTAPRENYLTRANSFER-MONOMER http://biocyc.org/getid?id=EcoCyc:4OHBENZOATE-OCTAPRENYLTRANSFER-MONOMER BioCyc MetaCyc:4OHBENZOATE-OCTAPRENYLTRANSFER-MONOMER http://biocyc.org/getid?id=MetaCyc:4OHBENZOATE-OCTAPRENYLTRANSFER-MONOMER COG COG0382 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0382 DOI 10.1016/0005-2760(94)90193-7 http://dx.doi.org/10.1016/0005-2760(94)90193-7 DOI 10.1016/0014-5793(92)80710-X http://dx.doi.org/10.1016/0014-5793(92)80710-X DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1099/00221287-139-8-1795 http://dx.doi.org/10.1099/00221287-139-8-1795 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1271/bbb.58.1814 http://dx.doi.org/10.1271/bbb.58.1814 EC_number EC:2.5.1.- {ECO:0000255|HAMAP-Rule:MF_01635} http://www.genome.jp/dbget-bin/www_bget?EC:2.5.1.- {ECO:0000255|HAMAP-Rule:MF_01635} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL DQ087228 http://www.ebi.ac.uk/ena/data/view/DQ087228 EMBL M93136 http://www.ebi.ac.uk/ena/data/view/M93136 EMBL M93413 http://www.ebi.ac.uk/ena/data/view/M93413 EMBL M96268 http://www.ebi.ac.uk/ena/data/view/M96268 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X57434 http://www.ebi.ac.uk/ena/data/view/X57434 EMBL X63407 http://www.ebi.ac.uk/ena/data/view/X63407 EMBL X66619 http://www.ebi.ac.uk/ena/data/view/X66619 EMBL X69522 http://www.ebi.ac.uk/ena/data/view/X69522 ENZYME 2.5.1.- {ECO:0000255|HAMAP-Rule:MF_01635} http://enzyme.expasy.org/EC/2.5.1.- {ECO:0000255|HAMAP-Rule:MF_01635} EchoBASE EB1344 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1344 EcoGene EG11370 http://www.ecogene.org/geneInfo.php?eg_id=EG11370 EnsemblBacteria AAC77010 http://www.ensemblgenomes.org/id/AAC77010 EnsemblBacteria AAC77010 http://www.ensemblgenomes.org/id/AAC77010 EnsemblBacteria BAE78042 http://www.ensemblgenomes.org/id/BAE78042 EnsemblBacteria BAE78042 http://www.ensemblgenomes.org/id/BAE78042 EnsemblBacteria BAE78042 http://www.ensemblgenomes.org/id/BAE78042 EnsemblBacteria b4040 http://www.ensemblgenomes.org/id/b4040 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008412 GO_function GO:0016765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016765 GO_process GO:0006744 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006744 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016765 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GeneID 948540 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948540 HAMAP MF_01635 http://hamap.expasy.org/unirule/MF_01635 HOGENOM HOG000003696 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000003696&db=HOGENOM6 InParanoid P0AGK1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGK1 IntEnz 2.5.1.- {ECO:0000255|HAMAP-Rule:MF_01635} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.5.1.- {ECO:0000255|HAMAP-Rule:MF_01635} InterPro IPR000537 http://www.ebi.ac.uk/interpro/entry/IPR000537 InterPro IPR006370 http://www.ebi.ac.uk/interpro/entry/IPR006370 InterPro IPR030470 http://www.ebi.ac.uk/interpro/entry/IPR030470 InterPro IPR031103 http://www.ebi.ac.uk/interpro/entry/IPR031103 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01006 http://www.genome.jp/dbget-bin/www_bget?ko01006 KEGG_Gene ecj:JW4000 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4000 KEGG_Gene eco:b4040 http://www.genome.jp/dbget-bin/www_bget?eco:b4040 KEGG_Orthology KO:K03179 http://www.genome.jp/dbget-bin/www_bget?KO:K03179 KEGG_Pathway ko00130 http://www.genome.jp/kegg-bin/show_pathway?ko00130 KEGG_Reaction rn:R05000 http://www.genome.jp/dbget-bin/www_bget?rn:R05000 KEGG_Reaction rn:R05615 http://www.genome.jp/dbget-bin/www_bget?rn:R05615 OMA IPMAFMA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IPMAFMA PROSITE PS00943 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00943 PSORT swissprot:UBIA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UBIA_ECOLI PSORT-B swissprot:UBIA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UBIA_ECOLI PSORT2 swissprot:UBIA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UBIA_ECOLI Pfam PF01040 http://pfam.xfam.org/family/PF01040 Phobius swissprot:UBIA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UBIA_ECOLI PhylomeDB P0AGK1 http://phylomedb.org/?seqid=P0AGK1 ProteinModelPortal P0AGK1 http://www.proteinmodelportal.org/query/uniprot/P0AGK1 PubMed 1512213 http://www.ncbi.nlm.nih.gov/pubmed/1512213 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 1644192 http://www.ncbi.nlm.nih.gov/pubmed/1644192 PubMed 1644758 http://www.ncbi.nlm.nih.gov/pubmed/1644758 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7765507 http://www.ncbi.nlm.nih.gov/pubmed/7765507 PubMed 8155731 http://www.ncbi.nlm.nih.gov/pubmed/8155731 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 8409922 http://www.ncbi.nlm.nih.gov/pubmed/8409922 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418464 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418464 RefSeq WP_000455227 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000455227 STRING 511145.b4040 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4040&targetmode=cogs STRING COG0382 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0382&targetmode=cogs TIGRFAMs TIGR01474 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01474 UniProtKB UBIA_ECOLI http://www.uniprot.org/uniprot/UBIA_ECOLI UniProtKB-AC P0AGK1 http://www.uniprot.org/uniprot/P0AGK1 charge swissprot:UBIA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UBIA_ECOLI eggNOG COG0382 http://eggnogapi.embl.de/nog_data/html/tree/COG0382 eggNOG ENOG4105C4G http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C4G epestfind swissprot:UBIA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UBIA_ECOLI garnier swissprot:UBIA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UBIA_ECOLI helixturnhelix swissprot:UBIA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UBIA_ECOLI hmoment swissprot:UBIA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UBIA_ECOLI iep swissprot:UBIA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UBIA_ECOLI inforesidue swissprot:UBIA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UBIA_ECOLI octanol swissprot:UBIA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UBIA_ECOLI pepcoil swissprot:UBIA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UBIA_ECOLI pepdigest swissprot:UBIA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UBIA_ECOLI pepinfo swissprot:UBIA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UBIA_ECOLI pepnet swissprot:UBIA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UBIA_ECOLI pepstats swissprot:UBIA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UBIA_ECOLI pepwheel swissprot:UBIA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UBIA_ECOLI pepwindow swissprot:UBIA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UBIA_ECOLI sigcleave swissprot:UBIA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UBIA_ECOLI ## Database ID URL or Descriptions # BioGrid 4263194 19 # CAZy GH65 Glycoside Hydrolase Family 65 # EcoGene EG13917 ycjT # GO_component GO:0005618 cell wall; IBA:GO_Central. # GO_function GO:0016787 hydrolase activity; IBA:GO_Central. # GO_function GO:0016798 hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW. # GO_function GO:0030246 carbohydrate binding; IEA:InterPro. # GO_process GO:0005975 carbohydrate metabolic process; IEA:InterPro. # GOslim_component GO:0005618 cell wall # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_process GO:0005975 carbohydrate metabolic process # Gene3D 1.50.10.10 -; 1. # Gene3D 2.70.98.40 -; 1. # InterPro IPR005194 Glyco_hydro_65_C # InterPro IPR005195 Glyco_hydro_65_M # InterPro IPR005196 Glyco_hydro_65_N # InterPro IPR008928 6-hairpin_glycosidase-like # InterPro IPR011013 Gal_mutarotase_SF_dom # InterPro IPR012341 6hp_glycosidase # InterPro IPR017045 Malt_Pase/Glycosyl_Hdrlase # KEGG_Brite ko01000 Enzymes # Organism YCJT_ECOLI Escherichia coli (strain K12) # PATRIC 32117904 VBIEscCol129921_1372 # PIR G64880 G64880 # PIRSF PIRSF036289 Glycosyl_hydrolase_malt_phosph # Pfam PF03632 Glyco_hydro_65m # Pfam PF03633 Glyco_hydro_65C # Pfam PF03636 Glyco_hydro_65N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCJT_ECOLI Uncharacterized glycosyl hydrolase YcjT # RefSeq NP_415832 NC_000913.3 # RefSeq WP_000198036 NZ_LN832404.1 # SIMILARITY Belongs to the glycosyl hydrolase 65 family. {ECO 0000305}. # SUPFAM SSF48208 SSF48208 # SUPFAM SSF74650 SSF74650 # eggNOG COG1554 LUCA # eggNOG ENOG4105C71 Bacteria BLAST swissprot:YCJT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCJT_ECOLI BioCyc ECOL316407:JW1309-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1309-MONOMER BioCyc EcoCyc:G6654-MONOMER http://biocyc.org/getid?id=EcoCyc:G6654-MONOMER COG COG1554 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1554 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.2.1.- http://www.genome.jp/dbget-bin/www_bget?EC:3.2.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.2.1.- http://enzyme.expasy.org/EC/3.2.1.- EchoBASE EB3676 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3676 EcoGene EG13917 http://www.ecogene.org/geneInfo.php?eg_id=EG13917 EnsemblBacteria AAC74398 http://www.ensemblgenomes.org/id/AAC74398 EnsemblBacteria AAC74398 http://www.ensemblgenomes.org/id/AAC74398 EnsemblBacteria BAA14891 http://www.ensemblgenomes.org/id/BAA14891 EnsemblBacteria BAA14891 http://www.ensemblgenomes.org/id/BAA14891 EnsemblBacteria BAA14891 http://www.ensemblgenomes.org/id/BAA14891 EnsemblBacteria b1316 http://www.ensemblgenomes.org/id/b1316 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005618 GO_function GO:0016787 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016787 GO_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GO_function GO:0030246 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030246 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_component GO:0005618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005618 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 Gene3D 1.50.10.10 http://www.cathdb.info/version/latest/superfamily/1.50.10.10 Gene3D 2.70.98.40 http://www.cathdb.info/version/latest/superfamily/2.70.98.40 GeneID 945895 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945895 HOGENOM HOG000055022 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000055022&db=HOGENOM6 InParanoid P77154 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77154 IntAct P77154 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77154* IntEnz 3.2.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.2.1 InterPro IPR005194 http://www.ebi.ac.uk/interpro/entry/IPR005194 InterPro IPR005195 http://www.ebi.ac.uk/interpro/entry/IPR005195 InterPro IPR005196 http://www.ebi.ac.uk/interpro/entry/IPR005196 InterPro IPR008928 http://www.ebi.ac.uk/interpro/entry/IPR008928 InterPro IPR011013 http://www.ebi.ac.uk/interpro/entry/IPR011013 InterPro IPR012341 http://www.ebi.ac.uk/interpro/entry/IPR012341 InterPro IPR017045 http://www.ebi.ac.uk/interpro/entry/IPR017045 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1309 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1309 KEGG_Gene eco:b1316 http://www.genome.jp/dbget-bin/www_bget?eco:b1316 KEGG_Orthology KO:K04844 http://www.genome.jp/dbget-bin/www_bget?KO:K04844 OMA HEEDYTS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HEEDYTS PSORT swissprot:YCJT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCJT_ECOLI PSORT-B swissprot:YCJT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCJT_ECOLI PSORT2 swissprot:YCJT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCJT_ECOLI Pfam PF03632 http://pfam.xfam.org/family/PF03632 Pfam PF03633 http://pfam.xfam.org/family/PF03633 Pfam PF03636 http://pfam.xfam.org/family/PF03636 Phobius swissprot:YCJT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCJT_ECOLI PhylomeDB P77154 http://phylomedb.org/?seqid=P77154 ProteinModelPortal P77154 http://www.proteinmodelportal.org/query/uniprot/P77154 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415832 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415832 RefSeq WP_000198036 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000198036 SMR P77154 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77154 STRING 511145.b1316 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1316&targetmode=cogs STRING COG1554 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1554&targetmode=cogs SUPFAM SSF48208 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48208 SUPFAM SSF74650 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF74650 UniProtKB YCJT_ECOLI http://www.uniprot.org/uniprot/YCJT_ECOLI UniProtKB-AC P77154 http://www.uniprot.org/uniprot/P77154 charge swissprot:YCJT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCJT_ECOLI eggNOG COG1554 http://eggnogapi.embl.de/nog_data/html/tree/COG1554 eggNOG ENOG4105C71 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C71 epestfind swissprot:YCJT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCJT_ECOLI garnier swissprot:YCJT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCJT_ECOLI helixturnhelix swissprot:YCJT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCJT_ECOLI hmoment swissprot:YCJT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCJT_ECOLI iep swissprot:YCJT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCJT_ECOLI inforesidue swissprot:YCJT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCJT_ECOLI octanol swissprot:YCJT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCJT_ECOLI pepcoil swissprot:YCJT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCJT_ECOLI pepdigest swissprot:YCJT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCJT_ECOLI pepinfo swissprot:YCJT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCJT_ECOLI pepnet swissprot:YCJT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCJT_ECOLI pepstats swissprot:YCJT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCJT_ECOLI pepwheel swissprot:YCJT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCJT_ECOLI pepwindow swissprot:YCJT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCJT_ECOLI sigcleave swissprot:YCJT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCJT_ECOLI ## Database ID URL or Descriptions # AltName TAUD_ECOLI 2-aminoethanesulfonate dioxygenase # AltName TAUD_ECOLI Sulfate starvation-induced protein 3 # BIOPHYSICOCHEMICAL PROPERTIES pH dependence Optimum pH is 6.9.; # BRENDA 1.14.11.17 2026 # BioGrid 4259830 11 # CATALYTIC ACTIVITY TAUD_ECOLI Taurine + 2-oxoglutarate + O(2) = sulfite + aminoacetaldehyde + succinate + CO(2). {ECO 0000269|PubMed 11955067, ECO 0000269|PubMed 12741810}. # COFACTOR TAUD_ECOLI Name=Fe(2+); Xref=ChEBI CHEBI 29033; Evidence={ECO 0000269|PubMed 11955067, ECO 0000269|PubMed 12741810}; Note=Binds 1 Fe(2+) ion per subunit. {ECO 0000269|PubMed 11955067, ECO 0000269|PubMed 12741810}; # ENZYME REGULATION TAUD_ECOLI Activated by ascorbate and inhibited by divalent metal ions such as zinc, copper and cobalt. # EcoGene EG12423 tauD # FUNCTION TAUD_ECOLI Catalyzes the conversion of taurine and alpha ketoglutarate to sulfite, aminoacetaldehyde and succinate. Required for the utilization of taurine (2-aminoethanesulfonic acid) as an alternative sulfur source. Pentane-sulfonic acid, 3- (N-morpholino)propanesulfonic acid and 1,3-dioxo-2- isoindolineethanesulfonic acid are also substrates for this enzyme. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_function GO:0000907 sulfonate dioxygenase activity; IBA:GO_Central. # GO_function GO:0000908 taurine dioxygenase activity; IDA:EcoliWiki. # GO_function GO:0031418 L-ascorbic acid binding; IEA:UniProtKB-KW. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006790 sulfur compound metabolic process; IMP:EcoliWiki. # GO_process GO:0044273 sulfur compound catabolic process; IBA:GO_Central. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009056 catabolic process # INDUCTION TAUD_ECOLI Repressed by sulfate or cysteine. # IntAct P37610 4 # InterPro IPR003819 TauD/TfdA-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00430 Taurine and hypotaurine metabolism # Organism TAUD_ECOLI Escherichia coli (strain K12) # PATHWAY Organosulfur degradation; taurine degradation via aerobic pathway; aminoacetaldehyde and sulfite from taurine step 1/1. # PATRIC 32115875 VBIEscCol129921_0379 # PDB 1GQW X-ray; 3.00 A; A/B=2-283 # PDB 1GY9 X-ray; 2.50 A; A/B=2-283 # PDB 1OS7 X-ray; 2.50 A; A/B/C/D=1-283 # PDB 1OTJ X-ray; 1.90 A; A/B/C/D=1-283 # PIR S78607 H64764 # Pfam PF02668 TauD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TAUD_ECOLI Alpha-ketoglutarate-dependent taurine dioxygenase # RefSeq NP_414902 NC_000913.3 # RefSeq WP_000004027 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=M24488; Type=Frameshift; Positions=244; Evidence={ECO 0000305}; # SIMILARITY Belongs to the TfdA dioxygenase family. {ECO 0000305}. # SUBUNIT TAUD_ECOLI Homodimer. {ECO 0000269|PubMed 11955067, ECO 0000269|PubMed 12741810}. # UniPathway UPA00336 UER00542 # eggNOG COG2175 LUCA # eggNOG ENOG4105E2B Bacteria BLAST swissprot:TAUD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TAUD_ECOLI BioCyc ECOL316407:JW0360-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0360-MONOMER BioCyc EcoCyc:MONOMER0-147 http://biocyc.org/getid?id=EcoCyc:MONOMER0-147 BioCyc MetaCyc:MONOMER0-147 http://biocyc.org/getid?id=MetaCyc:MONOMER0-147 COG COG2175 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2175 DIP DIP-10966N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10966N DOI 10.1016/0378-1119(89)90394-6 http://dx.doi.org/10.1016/0378-1119(89)90394-6 DOI 10.1021/bi016014e http://dx.doi.org/10.1021/bi016014e DOI 10.1021/bi0341096 http://dx.doi.org/10.1021/bi0341096 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.272.37.23031 http://dx.doi.org/10.1074/jbc.272.37.23031 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1111/j.1432-1033.1996.0773u.x http://dx.doi.org/10.1111/j.1432-1033.1996.0773u.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.14.11.17 http://www.genome.jp/dbget-bin/www_bget?EC:1.14.11.17 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D85613 http://www.ebi.ac.uk/ena/data/view/D85613 EMBL M24488 http://www.ebi.ac.uk/ena/data/view/M24488 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 ENZYME 1.14.11.17 http://enzyme.expasy.org/EC/1.14.11.17 EchoBASE EB2322 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2322 EcoGene EG12423 http://www.ecogene.org/geneInfo.php?eg_id=EG12423 EnsemblBacteria AAC73471 http://www.ensemblgenomes.org/id/AAC73471 EnsemblBacteria AAC73471 http://www.ensemblgenomes.org/id/AAC73471 EnsemblBacteria BAE76149 http://www.ensemblgenomes.org/id/BAE76149 EnsemblBacteria BAE76149 http://www.ensemblgenomes.org/id/BAE76149 EnsemblBacteria BAE76149 http://www.ensemblgenomes.org/id/BAE76149 EnsemblBacteria b0368 http://www.ensemblgenomes.org/id/b0368 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000907 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000907 GO_function GO:0000908 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000908 GO_function GO:0031418 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031418 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GO_process GO:0044273 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044273 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GeneID 945021 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945021 HOGENOM HOG000165071 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000165071&db=HOGENOM6 InParanoid P37610 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37610 IntAct P37610 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37610* IntEnz 1.14.11.17 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.14.11.17 InterPro IPR003819 http://www.ebi.ac.uk/interpro/entry/IPR003819 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0360 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0360 KEGG_Gene eco:b0368 http://www.genome.jp/dbget-bin/www_bget?eco:b0368 KEGG_Orthology KO:K03119 http://www.genome.jp/dbget-bin/www_bget?KO:K03119 KEGG_Pathway ko00430 http://www.genome.jp/kegg-bin/show_pathway?ko00430 KEGG_Reaction rn:R05320 http://www.genome.jp/dbget-bin/www_bget?rn:R05320 MINT MINT-8299483 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8299483 OMA ATHDFTK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ATHDFTK PDB 1GQW http://www.ebi.ac.uk/pdbe-srv/view/entry/1GQW PDB 1GY9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1GY9 PDB 1OS7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1OS7 PDB 1OTJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1OTJ PDBsum 1GQW http://www.ebi.ac.uk/pdbsum/1GQW PDBsum 1GY9 http://www.ebi.ac.uk/pdbsum/1GY9 PDBsum 1OS7 http://www.ebi.ac.uk/pdbsum/1OS7 PDBsum 1OTJ http://www.ebi.ac.uk/pdbsum/1OTJ PSORT swissprot:TAUD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TAUD_ECOLI PSORT-B swissprot:TAUD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TAUD_ECOLI PSORT2 swissprot:TAUD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TAUD_ECOLI Pfam PF02668 http://pfam.xfam.org/family/PF02668 Phobius swissprot:TAUD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TAUD_ECOLI PhylomeDB P37610 http://phylomedb.org/?seqid=P37610 ProteinModelPortal P37610 http://www.proteinmodelportal.org/query/uniprot/P37610 PubMed 11955067 http://www.ncbi.nlm.nih.gov/pubmed/11955067 PubMed 12741810 http://www.ncbi.nlm.nih.gov/pubmed/12741810 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2656410 http://www.ncbi.nlm.nih.gov/pubmed/2656410 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 8774726 http://www.ncbi.nlm.nih.gov/pubmed/8774726 PubMed 8808933 http://www.ncbi.nlm.nih.gov/pubmed/8808933 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9287300 http://www.ncbi.nlm.nih.gov/pubmed/9287300 RefSeq NP_414902 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414902 RefSeq WP_000004027 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000004027 SMR P37610 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37610 STRING 511145.b0368 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0368&targetmode=cogs STRING COG2175 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2175&targetmode=cogs UniProtKB TAUD_ECOLI http://www.uniprot.org/uniprot/TAUD_ECOLI UniProtKB-AC P37610 http://www.uniprot.org/uniprot/P37610 charge swissprot:TAUD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TAUD_ECOLI eggNOG COG2175 http://eggnogapi.embl.de/nog_data/html/tree/COG2175 eggNOG ENOG4105E2B http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E2B epestfind swissprot:TAUD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TAUD_ECOLI garnier swissprot:TAUD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TAUD_ECOLI helixturnhelix swissprot:TAUD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TAUD_ECOLI hmoment swissprot:TAUD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TAUD_ECOLI iep swissprot:TAUD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TAUD_ECOLI inforesidue swissprot:TAUD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TAUD_ECOLI octanol swissprot:TAUD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TAUD_ECOLI pepcoil swissprot:TAUD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TAUD_ECOLI pepdigest swissprot:TAUD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TAUD_ECOLI pepinfo swissprot:TAUD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TAUD_ECOLI pepnet swissprot:TAUD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TAUD_ECOLI pepstats swissprot:TAUD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TAUD_ECOLI pepwheel swissprot:TAUD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TAUD_ECOLI pepwindow swissprot:TAUD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TAUD_ECOLI sigcleave swissprot:TAUD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TAUD_ECOLI ## Database ID URL or Descriptions # AltName SELA_ECOLI Selenocysteine synthase # AltName SELA_ECOLI Selenocysteinyl-tRNA(Sec) synthase # BioGrid 4261876 5 # CATALYTIC ACTIVITY L-seryl-tRNA(Sec) + selenophosphate = L- selenocysteinyl-tRNA(Sec) + phosphate. {ECO:0000269|PubMed 2007585}. # COFACTOR SELA_ECOLI Name=pyridoxal 5'-phosphate; Xref=ChEBI CHEBI 597326; Evidence={ECO 0000269|PubMed 2007584}; # EcoGene EG10941 selA # FUNCTION SELA_ECOLI Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. Requires selenophosphate as the selenium-donor molecule. {ECO 0000269|PubMed 2007584, ECO 0000269|PubMed 2007585}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004125 L-seryl-tRNASec selenium transferase activity; IDA:EcoCyc. # GO_function GO:0030170 pyridoxal phosphate binding; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0001514 selenocysteine incorporation; IEA:UniProtKB-HAMAP. # GO_process GO:0016260 selenocysteine biosynthetic process; IMP:EcoCyc. # GO_process GO:0097056 selenocysteinyl-tRNA(Sec) biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.640.10 -; 1. # HAMAP MF_00423 SelA # IntAct P0A821 2 # InterPro IPR004534 SelA_trans # InterPro IPR015421 PyrdxlP-dep_Trfase_major_sub1 # InterPro IPR015424 PyrdxlP-dep_Trfase # InterPro IPR018319 SelA-like # InterPro IPR025862 SelA_trans_N_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00450 Selenocompound metabolism # KEGG_Pathway ko00970 Aminoacyl-tRNA biosynthesis # Organism SELA_ECOLI Escherichia coli (strain K12) # PATHWAY Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (bacterial route) step 1/1. # PATRIC 32122660 VBIEscCol129921_3707 # PIR A65159 A65159 # Pfam PF03841 SelA # Pfam PF12390 Se-cys_synth_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SELA_ECOLI L-seryl-tRNA(Sec) selenium transferase # RefSeq NP_418048 NC_000913.3 # RefSeq WP_000206223 NZ_CP014272.1 # RefSeq WP_000206275 NZ_LN832404.1 # SIMILARITY Belongs to the SelA family. {ECO 0000305}. # SUBCELLULAR LOCATION SELA_ECOLI Cytoplasm. # SUBUNIT Homodecamer; pentamer of dimers. Binds only one seryl- tRNA(Sec) per dimer. {ECO:0000269|PubMed 1474891}. # SUPFAM SSF53383 SSF53383 # TIGRFAMs TIGR00474 selA # UniPathway UPA00906 UER00896 # eggNOG COG1921 LUCA # eggNOG ENOG4105C1Y Bacteria BLAST swissprot:SELA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SELA_ECOLI BioCyc ECOL316407:JW3564-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3564-MONOMER BioCyc EcoCyc:EG10941-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10941-MONOMER BioCyc MetaCyc:EG10941-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10941-MONOMER COG COG1921 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1921 DIP DIP-10847N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10847N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1432-1327.1998.2540655.x http://dx.doi.org/10.1046/j.1432-1327.1998.2540655.x DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1111/j.1365-2958.1992.tb01781.x http://dx.doi.org/10.1111/j.1365-2958.1992.tb01781.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.9.1.1 http://www.genome.jp/dbget-bin/www_bget?EC:2.9.1.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M64177 http://www.ebi.ac.uk/ena/data/view/M64177 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.9.1.1 http://enzyme.expasy.org/EC/2.9.1.1 EchoBASE EB0934 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0934 EcoGene EG10941 http://www.ecogene.org/geneInfo.php?eg_id=EG10941 EnsemblBacteria AAC76615 http://www.ensemblgenomes.org/id/AAC76615 EnsemblBacteria AAC76615 http://www.ensemblgenomes.org/id/AAC76615 EnsemblBacteria BAE77702 http://www.ensemblgenomes.org/id/BAE77702 EnsemblBacteria BAE77702 http://www.ensemblgenomes.org/id/BAE77702 EnsemblBacteria BAE77702 http://www.ensemblgenomes.org/id/BAE77702 EnsemblBacteria b3591 http://www.ensemblgenomes.org/id/b3591 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004125 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004125 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0001514 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001514 GO_process GO:0016260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016260 GO_process GO:0097056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097056 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.640.10 http://www.cathdb.info/version/latest/superfamily/3.40.640.10 GeneID 948124 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948124 HAMAP MF_00423 http://hamap.expasy.org/unirule/MF_00423 HOGENOM HOG000163726 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000163726&db=HOGENOM6 InParanoid P0A821 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A821 IntAct P0A821 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A821* IntEnz 2.9.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.9.1.1 InterPro IPR004534 http://www.ebi.ac.uk/interpro/entry/IPR004534 InterPro IPR015421 http://www.ebi.ac.uk/interpro/entry/IPR015421 InterPro IPR015424 http://www.ebi.ac.uk/interpro/entry/IPR015424 InterPro IPR018319 http://www.ebi.ac.uk/interpro/entry/IPR018319 InterPro IPR025862 http://www.ebi.ac.uk/interpro/entry/IPR025862 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3564 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3564 KEGG_Gene eco:b3591 http://www.genome.jp/dbget-bin/www_bget?eco:b3591 KEGG_Orthology KO:K01042 http://www.genome.jp/dbget-bin/www_bget?KO:K01042 KEGG_Pathway ko00450 http://www.genome.jp/kegg-bin/show_pathway?ko00450 KEGG_Pathway ko00970 http://www.genome.jp/kegg-bin/show_pathway?ko00970 KEGG_Reaction rn:R08219 http://www.genome.jp/dbget-bin/www_bget?rn:R08219 OMA NRTHARD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NRTHARD PSORT swissprot:SELA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SELA_ECOLI PSORT-B swissprot:SELA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SELA_ECOLI PSORT2 swissprot:SELA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SELA_ECOLI Pfam PF03841 http://pfam.xfam.org/family/PF03841 Pfam PF12390 http://pfam.xfam.org/family/PF12390 Phobius swissprot:SELA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SELA_ECOLI PhylomeDB P0A821 http://phylomedb.org/?seqid=P0A821 ProteinModelPortal P0A821 http://www.proteinmodelportal.org/query/uniprot/P0A821 PubMed 1474891 http://www.ncbi.nlm.nih.gov/pubmed/1474891 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2007584 http://www.ncbi.nlm.nih.gov/pubmed/2007584 PubMed 2007585 http://www.ncbi.nlm.nih.gov/pubmed/2007585 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9688279 http://www.ncbi.nlm.nih.gov/pubmed/9688279 RefSeq NP_418048 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418048 RefSeq WP_000206223 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000206223 RefSeq WP_000206275 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000206275 SMR P0A821 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A821 STRING 511145.b3591 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3591&targetmode=cogs STRING COG1921 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1921&targetmode=cogs SUPFAM SSF53383 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53383 TIGRFAMs TIGR00474 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00474 UniProtKB SELA_ECOLI http://www.uniprot.org/uniprot/SELA_ECOLI UniProtKB-AC P0A821 http://www.uniprot.org/uniprot/P0A821 charge swissprot:SELA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SELA_ECOLI eggNOG COG1921 http://eggnogapi.embl.de/nog_data/html/tree/COG1921 eggNOG ENOG4105C1Y http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C1Y epestfind swissprot:SELA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SELA_ECOLI garnier swissprot:SELA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SELA_ECOLI helixturnhelix swissprot:SELA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SELA_ECOLI hmoment swissprot:SELA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SELA_ECOLI iep swissprot:SELA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SELA_ECOLI inforesidue swissprot:SELA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SELA_ECOLI octanol swissprot:SELA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SELA_ECOLI pepcoil swissprot:SELA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SELA_ECOLI pepdigest swissprot:SELA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SELA_ECOLI pepinfo swissprot:SELA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SELA_ECOLI pepnet swissprot:SELA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SELA_ECOLI pepstats swissprot:SELA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SELA_ECOLI pepwheel swissprot:SELA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SELA_ECOLI pepwindow swissprot:SELA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SELA_ECOLI sigcleave swissprot:SELA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SELA_ECOLI ## Database ID URL or Descriptions # AltName 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase {ECO:0000255|HAMAP-Rule MF_00159} # AltName ISPG_ECOLI Protein GcpE # BIOPHYSICOCHEMICAL PROPERTIES pH dependence: Optimum pH is 9. {ECO 0000269|PubMed:16268586}; # BRENDA 1.17.7 2026 # BioGrid 4260590 337 # CATALYTIC ACTIVITY ISPG_ECOLI (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H(2)O + oxidized flavodoxin = 2-C-methyl-D- erythritol 2,4-cyclodiphosphate + reduced flavodoxin. {ECO 0000255|HAMAP-Rule MF_00159, ECO 0000269|PubMed 12434382, ECO 0000269|PubMed 12571359, ECO 0000269|PubMed 16268586}. # COFACTOR ISPG_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000255|HAMAP-Rule MF_00159, ECO 0000269|PubMed 12434382, ECO 0000269|PubMed 16268586}; Note=Binds 1 [4Fe-4S] cluster. {ECO 0000255|HAMAP-Rule MF_00159, ECO 0000269|PubMed 12434382, ECO 0000269|PubMed 16268586}; # EcoGene EG10370 ispG # FUNCTION ISPG_ECOLI Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate, using flavodoxin as the reducing agent. {ECO 0000255|HAMAP- Rule MF_00159, ECO 0000269|PubMed 15978585, ECO 0000269|PubMed 16268586}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0005506 iron ion binding; IEA:InterPro. # GO_function GO:0046429 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IDA:EcoCyc. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IDA:EcoCyc. # GO_process GO:0016114 terpenoid biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0019288 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.70 -; 1. # HAMAP MF_00159 IspG # INTERACTION ISPG_ECOLI P77188 ecpB; NbExp=2; IntAct=EBI-550338, EBI-1113651; # IntAct P62620 10 # InterPro IPR004588 IspG_bac-typ # InterPro IPR011005 Dihydropteroate_synth-like # InterPro IPR013785 Aldolase_TIM # InterPro IPR016425 IspG_bac # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00900 Terpenoid backbone biosynthesis # Organism ISPG_ECOLI Escherichia coli (strain K12) # PATHWAY ISPG_ECOLI Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1- deoxy-D-xylulose 5-phosphate step 5/6. {ECO 0000255|HAMAP- Rule MF_00159, ECO 0000269|PubMed 11163766, ECO 0000269|PubMed 11274098}. # PATRIC 32120423 VBIEscCol129921_2614 # PIR S23058 S23058 # PIRSF PIRSF004640 IspG # Pfam PF04551 GcpE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) {ECO:0000255|HAMAP-Rule MF_00159} # RefSeq NP_417010 NC_000913.3 # RefSeq WP_000551807 NZ_LN832404.1 # SIMILARITY Belongs to the IspG family. {ECO:0000255|HAMAP- Rule MF_00159}. # SUPFAM SSF51717 SSF51717 # TIGRFAMs TIGR00612 ispG_gcpE # UniPathway UPA00056 UER00096 # eggNOG COG0821 LUCA # eggNOG ENOG4105C4E Bacteria BLAST swissprot:ISPG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ISPG_ECOLI BioCyc ECOL316407:JW2499-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2499-MONOMER BioCyc EcoCyc:EG10370-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10370-MONOMER BioCyc MetaCyc:EG10370-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10370-MONOMER COG COG0821 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0821 DIP DIP-35832N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35832N DOI 10.1002/1521-3773(20021115)41:22<4337::AID-ANIE4337>3.0.CO http://dx.doi.org/10.1002/1521-3773(20021115)41:22<4337::AID-ANIE4337>3.0.CO DOI 10.1016/0378-1097(92)90604-M http://dx.doi.org/10.1016/0378-1097(92)90604-M DOI 10.1016/S0006-291X(03)01211-7 http://dx.doi.org/10.1016/S0006-291X(03)01211-7 DOI 10.1016/S0014-5793(00)02420-0 http://dx.doi.org/10.1016/S0014-5793(00)02420-0 DOI 10.1016/j.febslet.2005.05.047 http://dx.doi.org/10.1016/j.febslet.2005.05.047 DOI 10.1021/jo0510787 http://dx.doi.org/10.1021/jo0510787 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0337742100 http://dx.doi.org/10.1073/pnas.0337742100 DOI 10.1073/pnas.201399298 http://dx.doi.org/10.1073/pnas.201399298 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.183.8.2411-2416.2001 http://dx.doi.org/10.1128/JB.183.8.2411-2416.2001 EC_number EC:1.17.7.3 {ECO:0000255|HAMAP-Rule:MF_00159, ECO:0000269|PubMed:12434382, ECO:0000269|PubMed:12571359, ECO:0000269|PubMed:16268586} http://www.genome.jp/dbget-bin/www_bget?EC:1.17.7.3 {ECO:0000255|HAMAP-Rule:MF_00159, ECO:0000269|PubMed:12434382, ECO:0000269|PubMed:12571359, ECO:0000269|PubMed:16268586} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL AY033515 http://www.ebi.ac.uk/ena/data/view/AY033515 EMBL M11843 http://www.ebi.ac.uk/ena/data/view/M11843 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X64451 http://www.ebi.ac.uk/ena/data/view/X64451 ENZYME 1.17.7.3 {ECO:0000255|HAMAP-Rule:MF_00159, ECO:0000269|PubMed:12434382, ECO:0000269|PubMed:12571359, ECO:0000269|PubMed:16268586} http://enzyme.expasy.org/EC/1.17.7.3 {ECO:0000255|HAMAP-Rule:MF_00159, ECO:0000269|PubMed:12434382, ECO:0000269|PubMed:12571359, ECO:0000269|PubMed:16268586} EchoBASE EB0365 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0365 EcoGene EG10370 http://www.ecogene.org/geneInfo.php?eg_id=EG10370 EnsemblBacteria AAC75568 http://www.ensemblgenomes.org/id/AAC75568 EnsemblBacteria AAC75568 http://www.ensemblgenomes.org/id/AAC75568 EnsemblBacteria BAA16402 http://www.ensemblgenomes.org/id/BAA16402 EnsemblBacteria BAA16402 http://www.ensemblgenomes.org/id/BAA16402 EnsemblBacteria BAA16402 http://www.ensemblgenomes.org/id/BAA16402 EnsemblBacteria b2515 http://www.ensemblgenomes.org/id/b2515 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0046429 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046429 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0016114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016114 GO_process GO:0019288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019288 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 946991 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946991 HAMAP MF_00159 http://hamap.expasy.org/unirule/MF_00159 HOGENOM HOG000261019 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261019&db=HOGENOM6 InParanoid P62620 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P62620 IntAct P62620 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P62620* IntEnz 1.17.7.3 {ECO:0000255|HAMAP-Rule:MF_00159, ECO:0000269|PubMed:12434382, ECO:0000269|PubMed:12571359, ECO:0000269|PubMed:16268586} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.17.7.3 {ECO:0000255|HAMAP-Rule:MF_00159, ECO:0000269|PubMed:12434382, ECO:0000269|PubMed:12571359, ECO:0000269|PubMed:16268586} InterPro IPR004588 http://www.ebi.ac.uk/interpro/entry/IPR004588 InterPro IPR011005 http://www.ebi.ac.uk/interpro/entry/IPR011005 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR016425 http://www.ebi.ac.uk/interpro/entry/IPR016425 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2499 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2499 KEGG_Gene eco:b2515 http://www.genome.jp/dbget-bin/www_bget?eco:b2515 KEGG_Orthology KO:K03526 http://www.genome.jp/dbget-bin/www_bget?KO:K03526 KEGG_Pathway ko00900 http://www.genome.jp/kegg-bin/show_pathway?ko00900 KEGG_Reaction rn:R08689 http://www.genome.jp/dbget-bin/www_bget?rn:R08689 OMA HNGMKIA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HNGMKIA PSORT swissprot:ISPG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ISPG_ECOLI PSORT-B swissprot:ISPG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ISPG_ECOLI PSORT2 swissprot:ISPG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ISPG_ECOLI Pfam PF04551 http://pfam.xfam.org/family/PF04551 Phobius swissprot:ISPG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ISPG_ECOLI PhylomeDB P62620 http://phylomedb.org/?seqid=P62620 ProteinModelPortal P62620 http://www.proteinmodelportal.org/query/uniprot/P62620 PubMed 11163766 http://www.ncbi.nlm.nih.gov/pubmed/11163766 PubMed 11274098 http://www.ncbi.nlm.nih.gov/pubmed/11274098 PubMed 11752431 http://www.ncbi.nlm.nih.gov/pubmed/11752431 PubMed 12434382 http://www.ncbi.nlm.nih.gov/pubmed/12434382 PubMed 12571359 http://www.ncbi.nlm.nih.gov/pubmed/12571359 PubMed 12859972 http://www.ncbi.nlm.nih.gov/pubmed/12859972 PubMed 1521767 http://www.ncbi.nlm.nih.gov/pubmed/1521767 PubMed 15978585 http://www.ncbi.nlm.nih.gov/pubmed/15978585 PubMed 16268586 http://www.ncbi.nlm.nih.gov/pubmed/16268586 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2991272 http://www.ncbi.nlm.nih.gov/pubmed/2991272 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417010 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417010 RefSeq WP_000551807 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000551807 SMR P62620 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P62620 STRING 511145.b2515 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2515&targetmode=cogs STRING COG0821 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0821&targetmode=cogs SUPFAM SSF51717 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51717 TIGRFAMs TIGR00612 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00612 UniProtKB ISPG_ECOLI http://www.uniprot.org/uniprot/ISPG_ECOLI UniProtKB-AC P62620 http://www.uniprot.org/uniprot/P62620 charge swissprot:ISPG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ISPG_ECOLI eggNOG COG0821 http://eggnogapi.embl.de/nog_data/html/tree/COG0821 eggNOG ENOG4105C4E http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C4E epestfind swissprot:ISPG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ISPG_ECOLI garnier swissprot:ISPG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ISPG_ECOLI helixturnhelix swissprot:ISPG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ISPG_ECOLI hmoment swissprot:ISPG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ISPG_ECOLI iep swissprot:ISPG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ISPG_ECOLI inforesidue swissprot:ISPG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ISPG_ECOLI octanol swissprot:ISPG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ISPG_ECOLI pepcoil swissprot:ISPG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ISPG_ECOLI pepdigest swissprot:ISPG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ISPG_ECOLI pepinfo swissprot:ISPG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ISPG_ECOLI pepnet swissprot:ISPG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ISPG_ECOLI pepstats swissprot:ISPG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ISPG_ECOLI pepwheel swissprot:ISPG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ISPG_ECOLI pepwindow swissprot:ISPG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ISPG_ECOLI sigcleave swissprot:ISPG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ISPG_ECOLI ## Database ID URL or Descriptions # AltName Flavin transferase {ECO:0000250|UniProtKB A5F5Y3} # BioGrid 4261922 14 # CATALYTIC ACTIVITY FAD + [protein]-L-threonine = [protein]-FMN-L- threonine + AMP. {ECO:0000250|UniProtKB A5F5Y3}. # COFACTOR APBE_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250|UniProtKB A5F5Y3}; # EcoGene EG12073 apbE # FUNCTION APBE_ECOLI Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein such as NqrB and NqrC, two subunits of the NQR complex. {ECO 0000250|UniProtKB A5F5Y3}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_function GO:0016740 transferase activity; IEA:UniProtKB-KW. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0017013 protein flavinylation; IEA:InterPro. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # InterPro IPR003374 ApbE-like # InterPro IPR024932 ApbE # Organism APBE_ECOLI Escherichia coli (strain K12) # PATRIC 32119787 VBIEscCol129921_2303 # PDB 2O18 X-ray; 2.20 A; A/B/C/D=21-351 # PDB 4XGV X-ray; 1.88 A; A/B/C/D=21-351 # PDB 4XGW X-ray; 1.75 A; A/B/C/D=21-351 # PDB 4XGX X-ray; 1.90 A; A/B=21-351 # PIR D64991 D64991 # PIRSF PIRSF006268 ApbE # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF02424 ApbE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FAD:protein FMN transferase {ECO 0000250|UniProtKB:A5F5Y3} # RefSeq NP_416718 NC_000913.3 # RefSeq WP_000406064 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA16404.1; Type=Frameshift; Positions=122; Note=Produces two separate ORFs.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ApbE family. {ECO 0000305}. # SUBCELLULAR LOCATION APBE_ECOLI Cell inner membrane {ECO 0000250|UniProtKB P41780, ECO 0000255|PROSITE- ProRule PRU00303}; Lipid-anchor {ECO 0000250|UniProtKB P41780, ECO 0000255|PROSITE-ProRule PRU00303}; Periplasmic side {ECO 0000250|UniProtKB P41780}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 23447540}. # SUPFAM SSF143631 SSF143631 # eggNOG COG1477 LUCA # eggNOG ENOG4105CJ2 Bacteria BLAST swissprot:APBE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:APBE_ECOLI BioCyc ECOL316407:JW5368-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5368-MONOMER BioCyc EcoCyc:EG12073-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12073-MONOMER COG COG1477 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1477 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M113.449975 http://dx.doi.org/10.1074/jbc.M113.449975 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.180 {ECO:0000250|UniProtKB:A5F5Y3} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.180 {ECO:0000250|UniProtKB:A5F5Y3} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00008 http://www.ebi.ac.uk/ena/data/view/U00008 EMBL U00008 http://www.ebi.ac.uk/ena/data/view/U00008 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.180 {ECO:0000250|UniProtKB:A5F5Y3} http://enzyme.expasy.org/EC/2.7.1.180 {ECO:0000250|UniProtKB:A5F5Y3} EchoBASE EB1998 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1998 EcoGene EG12073 http://www.ecogene.org/geneInfo.php?eg_id=EG12073 EnsemblBacteria AAC75274 http://www.ensemblgenomes.org/id/AAC75274 EnsemblBacteria AAC75274 http://www.ensemblgenomes.org/id/AAC75274 EnsemblBacteria BAA15997 http://www.ensemblgenomes.org/id/BAA15997 EnsemblBacteria BAA15997 http://www.ensemblgenomes.org/id/BAA15997 EnsemblBacteria BAA15997 http://www.ensemblgenomes.org/id/BAA15997 EnsemblBacteria b2214 http://www.ensemblgenomes.org/id/b2214 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0016740 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016740 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0017013 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017013 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GeneID 946711 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946711 HOGENOM HOG000080808 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000080808&db=HOGENOM6 InParanoid P0AB85 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AB85 IntEnz 2.7.1.180 {ECO:0000250|UniProtKB:A5F5Y3} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.180 {ECO:0000250|UniProtKB:A5F5Y3} InterPro IPR003374 http://www.ebi.ac.uk/interpro/entry/IPR003374 InterPro IPR024932 http://www.ebi.ac.uk/interpro/entry/IPR024932 KEGG_Gene ecj:JW5368 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5368 KEGG_Gene eco:b2214 http://www.genome.jp/dbget-bin/www_bget?eco:b2214 KEGG_Orthology KO:K03734 http://www.genome.jp/dbget-bin/www_bget?KO:K03734 OMA MGTFWRV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MGTFWRV PDB 2O18 http://www.ebi.ac.uk/pdbe-srv/view/entry/2O18 PDB 4XGV http://www.ebi.ac.uk/pdbe-srv/view/entry/4XGV PDB 4XGW http://www.ebi.ac.uk/pdbe-srv/view/entry/4XGW PDB 4XGX http://www.ebi.ac.uk/pdbe-srv/view/entry/4XGX PDBsum 2O18 http://www.ebi.ac.uk/pdbsum/2O18 PDBsum 4XGV http://www.ebi.ac.uk/pdbsum/4XGV PDBsum 4XGW http://www.ebi.ac.uk/pdbsum/4XGW PDBsum 4XGX http://www.ebi.ac.uk/pdbsum/4XGX PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:APBE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:APBE_ECOLI PSORT-B swissprot:APBE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:APBE_ECOLI PSORT2 swissprot:APBE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:APBE_ECOLI Pfam PF02424 http://pfam.xfam.org/family/PF02424 Phobius swissprot:APBE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:APBE_ECOLI PhylomeDB P0AB85 http://phylomedb.org/?seqid=P0AB85 ProteinModelPortal P0AB85 http://www.proteinmodelportal.org/query/uniprot/P0AB85 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 23447540 http://www.ncbi.nlm.nih.gov/pubmed/23447540 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416718 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416718 RefSeq WP_000406064 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000406064 SMR P0AB85 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AB85 STRING 511145.b2214 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2214&targetmode=cogs STRING COG1477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1477&targetmode=cogs SUPFAM SSF143631 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF143631 UniProtKB APBE_ECOLI http://www.uniprot.org/uniprot/APBE_ECOLI UniProtKB-AC P0AB85 http://www.uniprot.org/uniprot/P0AB85 charge swissprot:APBE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:APBE_ECOLI eggNOG COG1477 http://eggnogapi.embl.de/nog_data/html/tree/COG1477 eggNOG ENOG4105CJ2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CJ2 epestfind swissprot:APBE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:APBE_ECOLI garnier swissprot:APBE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:APBE_ECOLI helixturnhelix swissprot:APBE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:APBE_ECOLI hmoment swissprot:APBE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:APBE_ECOLI iep swissprot:APBE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:APBE_ECOLI inforesidue swissprot:APBE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:APBE_ECOLI octanol swissprot:APBE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:APBE_ECOLI pepcoil swissprot:APBE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:APBE_ECOLI pepdigest swissprot:APBE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:APBE_ECOLI pepinfo swissprot:APBE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:APBE_ECOLI pepnet swissprot:APBE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:APBE_ECOLI pepstats swissprot:APBE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:APBE_ECOLI pepwheel swissprot:APBE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:APBE_ECOLI pepwindow swissprot:APBE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:APBE_ECOLI sigcleave swissprot:APBE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:APBE_ECOLI ## Database ID URL or Descriptions # BioGrid 4262634 179 # CDD cd06174 MFS # EcoGene EG11840 yihN # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IBA:GO_Central. # GO_function GO:0022857 transmembrane transporter activity; IBA:GO_Central. # GO_process GO:0006820 anion transport; IBA:GO_Central. # GO_process GO:0055085 transmembrane transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # INDUCTION Down-regulated by cystine. {ECO:0000269|PubMed 25346166}. # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # Organism YIHN_ECOLI Escherichia coli (strain K12) # PATRIC 32123251 VBIEscCol129921_3986 # PIR S40819 S40819 # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Inner membrane protein YihN {ECO 0000305} # RefSeq NP_418310 NC_000913.3 # RefSeq WP_000956313 NZ_LN832404.1 # SIMILARITY Belongs to the major facilitator superfamily. {ECO 0000305}. # SUBCELLULAR LOCATION YIHN_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255}. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.52 the major facilitator superfamily (mfs) # eggNOG ENOG4105R9B Bacteria # eggNOG ENOG410XQHZ LUCA BLAST swissprot:YIHN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIHN_ECOLI BioCyc ECOL316407:JW3845-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3845-MONOMER BioCyc EcoCyc:YIHN-MONOMER http://biocyc.org/getid?id=EcoCyc:YIHN-MONOMER DIP DIP-12495N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12495N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1080/09168451.2014.972328 http://dx.doi.org/10.1080/09168451.2014.972328 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1786 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1786 EcoGene EG11840 http://www.ecogene.org/geneInfo.php?eg_id=EG11840 EnsemblBacteria AAC76871 http://www.ensemblgenomes.org/id/AAC76871 EnsemblBacteria AAC76871 http://www.ensemblgenomes.org/id/AAC76871 EnsemblBacteria BAE77435 http://www.ensemblgenomes.org/id/BAE77435 EnsemblBacteria BAE77435 http://www.ensemblgenomes.org/id/BAE77435 EnsemblBacteria BAE77435 http://www.ensemblgenomes.org/id/BAE77435 EnsemblBacteria b3874 http://www.ensemblgenomes.org/id/b3874 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GO_process GO:0006820 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006820 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 948365 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948365 HOGENOM HOG000127507 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000127507&db=HOGENOM6 IntAct P32135 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32135* InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Gene ecj:JW3845 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3845 KEGG_Gene eco:b3874 http://www.genome.jp/dbget-bin/www_bget?eco:b3874 MINT MINT-1286054 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1286054 OMA CDMLNWP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CDMLNWP PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:YIHN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIHN_ECOLI PSORT-B swissprot:YIHN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIHN_ECOLI PSORT2 swissprot:YIHN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIHN_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:YIHN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIHN_ECOLI PhylomeDB P32135 http://phylomedb.org/?seqid=P32135 ProteinModelPortal P32135 http://www.proteinmodelportal.org/query/uniprot/P32135 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 25346166 http://www.ncbi.nlm.nih.gov/pubmed/25346166 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418310 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418310 RefSeq WP_000956313 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000956313 STRING 511145.b3874 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3874&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.52 http://www.tcdb.org/search/result.php?tc=2.A.1.52 UniProtKB YIHN_ECOLI http://www.uniprot.org/uniprot/YIHN_ECOLI UniProtKB-AC P32135 http://www.uniprot.org/uniprot/P32135 charge swissprot:YIHN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIHN_ECOLI eggNOG ENOG4105R9B http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105R9B eggNOG ENOG410XQHZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQHZ epestfind swissprot:YIHN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIHN_ECOLI garnier swissprot:YIHN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIHN_ECOLI helixturnhelix swissprot:YIHN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIHN_ECOLI hmoment swissprot:YIHN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIHN_ECOLI iep swissprot:YIHN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIHN_ECOLI inforesidue swissprot:YIHN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIHN_ECOLI octanol swissprot:YIHN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIHN_ECOLI pepcoil swissprot:YIHN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIHN_ECOLI pepdigest swissprot:YIHN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIHN_ECOLI pepinfo swissprot:YIHN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIHN_ECOLI pepnet swissprot:YIHN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIHN_ECOLI pepstats swissprot:YIHN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIHN_ECOLI pepwheel swissprot:YIHN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIHN_ECOLI pepwindow swissprot:YIHN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIHN_ECOLI sigcleave swissprot:YIHN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIHN_ECOLI ## Database ID URL or Descriptions # BioGrid 4262020 8 # EcoGene EG10720 phnK # FUNCTION PHNK_ECOLI Belongs to an operon involved in alkylphosphonate uptake and C-P lyase. Exact function not known. PhnK is not required for the ribophosphonate triphosphate (RPnTP) synthase reaction. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016887 ATPase activity; IEA:InterPro. # GO_process GO:0006810 transport; IEA:UniProtKB-KW. # GO_process GO:0019700 organic phosphonate catabolic process; IMP:EcoCyc. # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # GOslim_process GO:0009056 catabolic process # Gene3D 3.40.50.300 -; 1. # IntAct P16678 6 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR012700 CP_lyase_PhnK # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00224 Putative phosphonate transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism PHNK_ECOLI Escherichia coli (strain K12) # PATRIC 32123753 VBIEscCol129921_4225 # PIR S56325 S56325 # PIRSF PIRSF037116 CP_lyase_PhnK # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # Pfam PF00005 ABC_tran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PHNK_ECOLI Putative phosphonates utilization ATP-binding protein PhnK # RefSeq WP_001075514 NZ_LN832404.1 # RefSeq YP_026282 NC_000913.3 # SIMILARITY Belongs to the ABC transporter superfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA # SUBUNIT Forms a complex with PhnG, PhnH, PhnI and PhnJ with the suggested composition PhnG(4)H(2)I(2)J(2)K. {ECO:0000269|PubMed 21705661}. # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR02323 CP_lyasePhnK # eggNOG COG4107 LUCA # eggNOG ENOG4105ENV Bacteria BLAST swissprot:PHNK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PHNK_ECOLI BioCyc ECOL316407:JW5727-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5727-MONOMER BioCyc EcoCyc:PHNK-MONOMER http://biocyc.org/getid?id=EcoCyc:PHNK-MONOMER BioCyc MetaCyc:PHNK-MONOMER http://biocyc.org/getid?id=MetaCyc:PHNK-MONOMER COG COG4107 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4107 DIP DIP-10490N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10490N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature10622 http://dx.doi.org/10.1038/nature10622 DOI 10.1073/pnas.1104922108 http://dx.doi.org/10.1073/pnas.1104922108 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D90227 http://www.ebi.ac.uk/ena/data/view/D90227 EMBL J05260 http://www.ebi.ac.uk/ena/data/view/J05260 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB0714 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0714 EcoGene EG10720 http://www.ecogene.org/geneInfo.php?eg_id=EG10720 EnsemblBacteria AAT48240 http://www.ensemblgenomes.org/id/AAT48240 EnsemblBacteria AAT48240 http://www.ensemblgenomes.org/id/AAT48240 EnsemblBacteria BAE78100 http://www.ensemblgenomes.org/id/BAE78100 EnsemblBacteria BAE78100 http://www.ensemblgenomes.org/id/BAE78100 EnsemblBacteria BAE78100 http://www.ensemblgenomes.org/id/BAE78100 EnsemblBacteria b4097 http://www.ensemblgenomes.org/id/b4097 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GO_process GO:0019700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019700 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948611 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948611 InParanoid P16678 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P16678 IntAct P16678 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P16678* InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR012700 http://www.ebi.ac.uk/interpro/entry/IPR012700 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5727 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5727 KEGG_Gene eco:b4097 http://www.genome.jp/dbget-bin/www_bget?eco:b4097 KEGG_Orthology KO:K05781 http://www.genome.jp/dbget-bin/www_bget?KO:K05781 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA STIGYTI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=STIGYTI PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:PHNK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PHNK_ECOLI PSORT-B swissprot:PHNK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PHNK_ECOLI PSORT2 swissprot:PHNK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PHNK_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Phobius swissprot:PHNK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PHNK_ECOLI PhylomeDB P16678 http://phylomedb.org/?seqid=P16678 ProteinModelPortal P16678 http://www.proteinmodelportal.org/query/uniprot/P16678 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1840580 http://www.ncbi.nlm.nih.gov/pubmed/1840580 PubMed 2155230 http://www.ncbi.nlm.nih.gov/pubmed/2155230 PubMed 21705661 http://www.ncbi.nlm.nih.gov/pubmed/21705661 PubMed 22089136 http://www.ncbi.nlm.nih.gov/pubmed/22089136 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001075514 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001075514 RefSeq YP_026282 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026282 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P16678 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P16678 STRING 511145.b4097 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4097&targetmode=cogs STRING COG4107 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4107&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR02323 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02323 UniProtKB PHNK_ECOLI http://www.uniprot.org/uniprot/PHNK_ECOLI UniProtKB-AC P16678 http://www.uniprot.org/uniprot/P16678 charge swissprot:PHNK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PHNK_ECOLI eggNOG COG4107 http://eggnogapi.embl.de/nog_data/html/tree/COG4107 eggNOG ENOG4105ENV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ENV epestfind swissprot:PHNK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PHNK_ECOLI garnier swissprot:PHNK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PHNK_ECOLI helixturnhelix swissprot:PHNK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PHNK_ECOLI hmoment swissprot:PHNK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PHNK_ECOLI iep swissprot:PHNK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PHNK_ECOLI inforesidue swissprot:PHNK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PHNK_ECOLI octanol swissprot:PHNK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PHNK_ECOLI pepcoil swissprot:PHNK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PHNK_ECOLI pepdigest swissprot:PHNK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PHNK_ECOLI pepinfo swissprot:PHNK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PHNK_ECOLI pepnet swissprot:PHNK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PHNK_ECOLI pepstats swissprot:PHNK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PHNK_ECOLI pepwheel swissprot:PHNK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PHNK_ECOLI pepwindow swissprot:PHNK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PHNK_ECOLI sigcleave swissprot:PHNK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PHNK_ECOLI ## Database ID URL or Descriptions # BioGrid 4260873 7 # EcoGene EG13821 ydfI # GO_function GO:0016491 oxidoreductase activity; IBA:GO_Central. # GO_function GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IBA:GO_Central. # GO_function GO:0050662 coenzyme binding; IEA:InterPro. # GO_process GO:0019594 mannitol metabolic process; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.1040.10 -; 1. # Gene3D 3.40.50.720 -; 1. # IntAct P77260 4 # InterPro IPR000669 Mannitol_DH # InterPro IPR008927 6-PGluconate_DH_C-like # InterPro IPR013118 Mannitol_DH_C # InterPro IPR013131 Mannitol_DH_N # InterPro IPR013328 6PGD_dom_2 # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR023027 Mannitol_DH_CS # Organism YDFI_ECOLI Escherichia coli (strain K12) # PATRIC 32118384 VBIEscCol129921_1612 # PIR A64909 A64909 # PRINTS PR00084 MTLDHDRGNASE # PROSITE PS00974 MANNITOL_DHGENASE # Pfam PF01232 Mannitol_dh # Pfam PF08125 Mannitol_dh_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDFI_ECOLI Uncharacterized oxidoreductase YdfI # RefSeq NP_416060 NC_000913.3 # RefSeq WP_000527743 NZ_LN832404.1 # SIMILARITY Belongs to the mannitol dehydrogenase family. UxuB subfamily. {ECO 0000305}. # SUPFAM SSF48179 SSF48179 # SUPFAM SSF51735 SSF51735 # eggNOG COG0246 LUCA # eggNOG ENOG4105DEI Bacteria BLAST swissprot:YDFI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDFI_ECOLI BioCyc ECOL316407:JW1535-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1535-MONOMER BioCyc EcoCyc:G6816-MONOMER http://biocyc.org/getid?id=EcoCyc:G6816-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- EchoBASE EB3582 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3582 EcoGene EG13821 http://www.ecogene.org/geneInfo.php?eg_id=EG13821 EnsemblBacteria AAC74615 http://www.ensemblgenomes.org/id/AAC74615 EnsemblBacteria AAC74615 http://www.ensemblgenomes.org/id/AAC74615 EnsemblBacteria BAA15243 http://www.ensemblgenomes.org/id/BAA15243 EnsemblBacteria BAA15243 http://www.ensemblgenomes.org/id/BAA15243 EnsemblBacteria BAA15243 http://www.ensemblgenomes.org/id/BAA15243 EnsemblBacteria b1542 http://www.ensemblgenomes.org/id/b1542 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0016616 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016616 GO_function GO:0050662 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050662 GO_process GO:0019594 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019594 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.1040.10 http://www.cathdb.info/version/latest/superfamily/1.10.1040.10 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 945861 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945861 HOGENOM HOG000202982 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000202982&db=HOGENOM6 InParanoid P77260 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77260 IntAct P77260 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77260* IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR000669 http://www.ebi.ac.uk/interpro/entry/IPR000669 InterPro IPR008927 http://www.ebi.ac.uk/interpro/entry/IPR008927 InterPro IPR013118 http://www.ebi.ac.uk/interpro/entry/IPR013118 InterPro IPR013131 http://www.ebi.ac.uk/interpro/entry/IPR013131 InterPro IPR013328 http://www.ebi.ac.uk/interpro/entry/IPR013328 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR023027 http://www.ebi.ac.uk/interpro/entry/IPR023027 KEGG_Gene ecj:JW1535 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1535 KEGG_Gene eco:b1542 http://www.genome.jp/dbget-bin/www_bget?eco:b1542 OMA PQWEKAG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PQWEKAG PRINTS PR00084 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00084 PROSITE PS00974 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00974 PSORT swissprot:YDFI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDFI_ECOLI PSORT-B swissprot:YDFI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDFI_ECOLI PSORT2 swissprot:YDFI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDFI_ECOLI Pfam PF01232 http://pfam.xfam.org/family/PF01232 Pfam PF08125 http://pfam.xfam.org/family/PF08125 Phobius swissprot:YDFI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDFI_ECOLI PhylomeDB P77260 http://phylomedb.org/?seqid=P77260 ProteinModelPortal P77260 http://www.proteinmodelportal.org/query/uniprot/P77260 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416060 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416060 RefSeq WP_000527743 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000527743 SMR P77260 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77260 STRING 511145.b1542 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1542&targetmode=cogs SUPFAM SSF48179 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48179 SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB YDFI_ECOLI http://www.uniprot.org/uniprot/YDFI_ECOLI UniProtKB-AC P77260 http://www.uniprot.org/uniprot/P77260 charge swissprot:YDFI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDFI_ECOLI eggNOG COG0246 http://eggnogapi.embl.de/nog_data/html/tree/COG0246 eggNOG ENOG4105DEI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DEI epestfind swissprot:YDFI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDFI_ECOLI garnier swissprot:YDFI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDFI_ECOLI helixturnhelix swissprot:YDFI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDFI_ECOLI hmoment swissprot:YDFI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDFI_ECOLI iep swissprot:YDFI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDFI_ECOLI inforesidue swissprot:YDFI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDFI_ECOLI octanol swissprot:YDFI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDFI_ECOLI pepcoil swissprot:YDFI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDFI_ECOLI pepdigest swissprot:YDFI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDFI_ECOLI pepinfo swissprot:YDFI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDFI_ECOLI pepnet swissprot:YDFI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDFI_ECOLI pepstats swissprot:YDFI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDFI_ECOLI pepwheel swissprot:YDFI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDFI_ECOLI pepwindow swissprot:YDFI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDFI_ECOLI sigcleave swissprot:YDFI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDFI_ECOLI ## Database ID URL or Descriptions # BioGrid 4259591 12 # EcoGene EG12592 yjjP # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # INDUCTION YJJP_ECOLI Has 2 promoters, 1 of which is repressed by H-NS. Activated by LeuO. A monocistronic operon. {ECO 0000269|PubMed 18055596, ECO 0000269|PubMed 19429622}. # InterPro IPR010619 ThrE # Organism YJJP_ECOLI Escherichia coli (strain K12) # PATRIC 32124336 VBIEscCol129921_4511 # PIR S56591 S56591 # Pfam PF06738 ThrE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJJP_ECOLI Inner membrane protein YjjP # RefSeq NP_418784 NC_000913.3 # RefSeq WP_001338213 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97263.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY To H.influenzae HI_0108. {ECO 0000305}. # SUBCELLULAR LOCATION YJJP_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG COG2966 LUCA # eggNOG ENOG4105DWK Bacteria BLAST swissprot:YJJP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJJP_ECOLI BioCyc ECOL316407:JW5796-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5796-MONOMER BioCyc EcoCyc:G7946-MONOMER http://biocyc.org/getid?id=EcoCyc:G7946-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00108-09 http://dx.doi.org/10.1128/JB.00108-09 DOI 10.1128/JB.01447-07 http://dx.doi.org/10.1128/JB.01447-07 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2477 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2477 EcoGene EG12592 http://www.ecogene.org/geneInfo.php?eg_id=EG12592 EnsemblBacteria AAC77320 http://www.ensemblgenomes.org/id/AAC77320 EnsemblBacteria AAC77320 http://www.ensemblgenomes.org/id/AAC77320 EnsemblBacteria BAE78354 http://www.ensemblgenomes.org/id/BAE78354 EnsemblBacteria BAE78354 http://www.ensemblgenomes.org/id/BAE78354 EnsemblBacteria BAE78354 http://www.ensemblgenomes.org/id/BAE78354 EnsemblBacteria b4364 http://www.ensemblgenomes.org/id/b4364 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 948812 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948812 HOGENOM HOG000282060 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000282060&db=HOGENOM6 InParanoid P0ADD5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADD5 InterPro IPR010619 http://www.ebi.ac.uk/interpro/entry/IPR010619 KEGG_Gene ecj:JW5796 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5796 KEGG_Gene eco:b4364 http://www.genome.jp/dbget-bin/www_bget?eco:b4364 OMA ITRLCIQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ITRLCIQ PSORT swissprot:YJJP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJJP_ECOLI PSORT-B swissprot:YJJP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJJP_ECOLI PSORT2 swissprot:YJJP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJJP_ECOLI Pfam PF06738 http://pfam.xfam.org/family/PF06738 Phobius swissprot:YJJP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJJP_ECOLI PhylomeDB P0ADD5 http://phylomedb.org/?seqid=P0ADD5 ProteinModelPortal P0ADD5 http://www.proteinmodelportal.org/query/uniprot/P0ADD5 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18055596 http://www.ncbi.nlm.nih.gov/pubmed/18055596 PubMed 19429622 http://www.ncbi.nlm.nih.gov/pubmed/19429622 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418784 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418784 RefSeq WP_001338213 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001338213 STRING 511145.b4364 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4364&targetmode=cogs UniProtKB YJJP_ECOLI http://www.uniprot.org/uniprot/YJJP_ECOLI UniProtKB-AC P0ADD5 http://www.uniprot.org/uniprot/P0ADD5 charge swissprot:YJJP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJJP_ECOLI eggNOG COG2966 http://eggnogapi.embl.de/nog_data/html/tree/COG2966 eggNOG ENOG4105DWK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DWK epestfind swissprot:YJJP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJJP_ECOLI garnier swissprot:YJJP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJJP_ECOLI helixturnhelix swissprot:YJJP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJJP_ECOLI hmoment swissprot:YJJP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJJP_ECOLI iep swissprot:YJJP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJJP_ECOLI inforesidue swissprot:YJJP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJJP_ECOLI octanol swissprot:YJJP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJJP_ECOLI pepcoil swissprot:YJJP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJJP_ECOLI pepdigest swissprot:YJJP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJJP_ECOLI pepinfo swissprot:YJJP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJJP_ECOLI pepnet swissprot:YJJP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJJP_ECOLI pepstats swissprot:YJJP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJJP_ECOLI pepwheel swissprot:YJJP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJJP_ECOLI pepwindow swissprot:YJJP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJJP_ECOLI sigcleave swissprot:YJJP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJJP_ECOLI ## Database ID URL or Descriptions # BioGrid 4262985 62 # CATALYTIC ACTIVITY DBPA_ECOLI ATP + H(2)O = ADP + phosphate. {ECO 0000255|HAMAP-Rule MF_00965, ECO 0000269|PubMed 11574482, ECO 0000269|PubMed 15910005, ECO 0000269|PubMed 18237742, ECO 0000269|PubMed 20160110}. # DOMAIN DBPA_ECOLI Contains an N-terminal domain that binds non-specifically to RNA and a C-terminal domain that binds specifically and tightly to hairpin 92 of 23S rRNA. {ECO 0000255|HAMAP-Rule MF_00965, ECO 0000269|PubMed 11350034, ECO 0000269|PubMed 11574482}. # ENZYME REGULATION DBPA_ECOLI Requires hairpin 92 of 23S rRNA for optimal activity. ATPase activity is stimulated by interaction of the N- terminal domain with RNA. {ECO 0000269|PubMed 11350034, ECO 0000269|PubMed 11574482, ECO 0000269|PubMed 18237742}. # EcoGene EG10210 dbpA # FUNCTION DBPA_ECOLI DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes. Requires a single-stranded RNA loading site on the 3' side of the substrate helix. {ECO 0000255|HAMAP- Rule MF_00965, ECO 0000269|PubMed 11350034, ECO 0000269|PubMed 11574482, ECO 0000269|PubMed 15910005, ECO 0000269|PubMed 18237742, ECO 0000269|PubMed 19734347, ECO 0000269|PubMed 20160110, ECO 0000269|PubMed 8253085, ECO 0000269|PubMed 9016593, ECO 0000269|PubMed 9836593}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003724 RNA helicase activity; IDA:EcoliWiki. # GO_function GO:0005524 ATP binding; IDA:EcoCyc. # GO_function GO:0016887 ATPase activity; IDA:EcoliWiki. # GO_function GO:0019843 rRNA binding; IDA:EcoCyc. # GO_function GO:0033677 DNA/RNA helicase activity; IDA:EcoliWiki. # GO_function GO:0034459 ATP-dependent 3'-5' RNA helicase activity; IDA:EcoCyc. # GO_function GO:0043531 ADP binding; IDA:EcoCyc. # GO_process GO:0000027 ribosomal large subunit assembly; IMP:EcoCyc. # GO_process GO:0010501 RNA secondary structure unwinding; IBA:GO_Central. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0004386 helicase activity # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0019843 rRNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0022618 ribonucleoprotein complex assembly # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.50.300 -; 2. # HAMAP MF_00965 DEAD_helicase_DbpA # IntAct P21693 6 # InterPro IPR000629 RNA-helicase_DEAD-box_CS # InterPro IPR001650 Helicase_C # InterPro IPR005580 DbpA_RNA-bd_dom # InterPro IPR011545 DEAD/DEAH_box_helicase_dom # InterPro IPR014001 Helicase_ATP-bd # InterPro IPR014014 RNA_helicase_DEAD_Q_motif # InterPro IPR027417 P-loop_NTPase # InterPro IPR028619 DEAD_helicase_DbpA # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # Organism DBPA_ECOLI Escherichia coli (strain K12) # PATRIC 32117966 VBIEscCol129921_1403 # PIR B64884 B64884 # PROSITE PS00039 DEAD_ATP_HELICASE # PROSITE PS51192 HELICASE_ATP_BIND_1 # PROSITE PS51194 HELICASE_CTER # PROSITE PS51195 Q_MOTIF # Pfam PF00270 DEAD # Pfam PF00271 Helicase_C # Pfam PF03880 DbpA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ATP-dependent RNA helicase DbpA {ECO:0000255|HAMAP-Rule MF_00965} # RefSeq NP_415859 NC_000913.3 # RefSeq WP_000123737 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA36872.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the DEAD box helicase family. DbpA subfamily. {ECO:0000255|HAMAP-Rule MF_00965}. # SIMILARITY Contains 1 helicase ATP-binding domain. {ECO:0000255|HAMAP-Rule MF_00965}. # SIMILARITY Contains 1 helicase C-terminal domain. {ECO:0000255|HAMAP-Rule MF_00965}. # SMART SM00487 DEXDc # SMART SM00490 HELICc # SUBCELLULAR LOCATION DBPA_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Monomer. {ECO:0000269|PubMed 16325852}. # SUPFAM SSF52540 SSF52540 # eggNOG COG0513 LUCA # eggNOG ENOG4105C1J Bacteria BLAST swissprot:DBPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DBPA_ECOLI BioCyc ECOL316407:JW1337-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1337-MONOMER BioCyc EcoCyc:EG10210-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10210-MONOMER BioCyc MetaCyc:EG10210-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10210-MONOMER COG COG0513 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0513 DOI 10.1016/j.jmb.2005.10.058 http://dx.doi.org/10.1016/j.jmb.2005.10.058 DOI 10.1016/j.jmb.2007.12.046 http://dx.doi.org/10.1016/j.jmb.2007.12.046 DOI 10.1017/S1355838201010135 http://dx.doi.org/10.1017/S1355838201010135 DOI 10.1021/bi050033x http://dx.doi.org/10.1021/bi050033x DOI 10.1021/bi981837y http://dx.doi.org/10.1021/bi981837y DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0913081107 http://dx.doi.org/10.1073/pnas.0913081107 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/emboj/20.19.5503 http://dx.doi.org/10.1093/emboj/20.19.5503 DOI 10.1093/nar/18.18.5413 http://dx.doi.org/10.1093/nar/18.18.5413 DOI 10.1093/nar/25.3.537 http://dx.doi.org/10.1093/nar/25.3.537 DOI 10.1093/nar/gkp711 http://dx.doi.org/10.1093/nar/gkp711 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.4.13 {ECO:0000255|HAMAP-Rule:MF_00965} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.4.13 {ECO:0000255|HAMAP-Rule:MF_00965} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X52647 http://www.ebi.ac.uk/ena/data/view/X52647 ENZYME 3.6.4.13 {ECO:0000255|HAMAP-Rule:MF_00965} http://enzyme.expasy.org/EC/3.6.4.13 {ECO:0000255|HAMAP-Rule:MF_00965} EchoBASE EB0206 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0206 EcoGene EG10210 http://www.ecogene.org/geneInfo.php?eg_id=EG10210 EnsemblBacteria AAC74425 http://www.ensemblgenomes.org/id/AAC74425 EnsemblBacteria AAC74425 http://www.ensemblgenomes.org/id/AAC74425 EnsemblBacteria BAA14946 http://www.ensemblgenomes.org/id/BAA14946 EnsemblBacteria BAA14946 http://www.ensemblgenomes.org/id/BAA14946 EnsemblBacteria BAA14946 http://www.ensemblgenomes.org/id/BAA14946 EnsemblBacteria b1343 http://www.ensemblgenomes.org/id/b1343 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003724 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003724 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GO_function GO:0033677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033677 GO_function GO:0034459 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034459 GO_function GO:0043531 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043531 GO_process GO:0000027 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000027 GO_process GO:0010501 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010501 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0004386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004386 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0022618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022618 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947153 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947153 HAMAP MF_00965 http://hamap.expasy.org/unirule/MF_00965 HOGENOM HOG000268809 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000268809&db=HOGENOM6 InParanoid P21693 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P21693 IntAct P21693 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P21693* IntEnz 3.6.4.13 {ECO:0000255|HAMAP-Rule:MF_00965} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.4.13 {ECO:0000255|HAMAP-Rule:MF_00965} InterPro IPR000629 http://www.ebi.ac.uk/interpro/entry/IPR000629 InterPro IPR001650 http://www.ebi.ac.uk/interpro/entry/IPR001650 InterPro IPR005580 http://www.ebi.ac.uk/interpro/entry/IPR005580 InterPro IPR011545 http://www.ebi.ac.uk/interpro/entry/IPR011545 InterPro IPR014001 http://www.ebi.ac.uk/interpro/entry/IPR014001 InterPro IPR014014 http://www.ebi.ac.uk/interpro/entry/IPR014014 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR028619 http://www.ebi.ac.uk/interpro/entry/IPR028619 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW1337 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1337 KEGG_Gene eco:b1343 http://www.genome.jp/dbget-bin/www_bget?eco:b1343 KEGG_Orthology KO:K05591 http://www.genome.jp/dbget-bin/www_bget?KO:K05591 OMA KKSGQNR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KKSGQNR PROSITE PS00039 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00039 PROSITE PS51192 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51192 PROSITE PS51194 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51194 PROSITE PS51195 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51195 PSORT swissprot:DBPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DBPA_ECOLI PSORT-B swissprot:DBPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DBPA_ECOLI PSORT2 swissprot:DBPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DBPA_ECOLI Pfam PF00270 http://pfam.xfam.org/family/PF00270 Pfam PF00271 http://pfam.xfam.org/family/PF00271 Pfam PF03880 http://pfam.xfam.org/family/PF03880 Phobius swissprot:DBPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DBPA_ECOLI PhylomeDB P21693 http://phylomedb.org/?seqid=P21693 ProteinModelPortal P21693 http://www.proteinmodelportal.org/query/uniprot/P21693 PubMed 11350034 http://www.ncbi.nlm.nih.gov/pubmed/11350034 PubMed 11574482 http://www.ncbi.nlm.nih.gov/pubmed/11574482 PubMed 15910005 http://www.ncbi.nlm.nih.gov/pubmed/15910005 PubMed 16325852 http://www.ncbi.nlm.nih.gov/pubmed/16325852 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18237742 http://www.ncbi.nlm.nih.gov/pubmed/18237742 PubMed 19734347 http://www.ncbi.nlm.nih.gov/pubmed/19734347 PubMed 20160110 http://www.ncbi.nlm.nih.gov/pubmed/20160110 PubMed 2216714 http://www.ncbi.nlm.nih.gov/pubmed/2216714 PubMed 8253085 http://www.ncbi.nlm.nih.gov/pubmed/8253085 PubMed 9016593 http://www.ncbi.nlm.nih.gov/pubmed/9016593 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9836593 http://www.ncbi.nlm.nih.gov/pubmed/9836593 RefSeq NP_415859 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415859 RefSeq WP_000123737 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000123737 SMART SM00487 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00487 SMART SM00490 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00490 SMR P21693 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P21693 STRING 511145.b1343 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1343&targetmode=cogs STRING COG0513 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0513&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB DBPA_ECOLI http://www.uniprot.org/uniprot/DBPA_ECOLI UniProtKB-AC P21693 http://www.uniprot.org/uniprot/P21693 charge swissprot:DBPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DBPA_ECOLI eggNOG COG0513 http://eggnogapi.embl.de/nog_data/html/tree/COG0513 eggNOG ENOG4105C1J http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C1J epestfind swissprot:DBPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DBPA_ECOLI garnier swissprot:DBPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DBPA_ECOLI helixturnhelix swissprot:DBPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DBPA_ECOLI hmoment swissprot:DBPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DBPA_ECOLI iep swissprot:DBPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DBPA_ECOLI inforesidue swissprot:DBPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DBPA_ECOLI octanol swissprot:DBPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DBPA_ECOLI pepcoil swissprot:DBPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DBPA_ECOLI pepdigest swissprot:DBPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DBPA_ECOLI pepinfo swissprot:DBPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DBPA_ECOLI pepnet swissprot:DBPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DBPA_ECOLI pepstats swissprot:DBPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DBPA_ECOLI pepwheel swissprot:DBPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DBPA_ECOLI pepwindow swissprot:DBPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DBPA_ECOLI sigcleave swissprot:DBPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DBPA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262188 4 # EcoGene EG10268 envY # FUNCTION ENVY_ECOLI Influences the temperature-dependent expression of several E.coli envelope proteins, most notably the porins OmpF and OmpC and the lambda receptor, LamB. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_component GO:0016020 membrane; IDA:EcoCyc. # GO_function GO:0000987 core promoter proximal region sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IBA:GO_Central. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IBA:GO_Central. # GO_process GO:0009266 response to temperature stimulus; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.60 -; 1. # IntAct P10805 14 # InterPro IPR009057 Homeodomain-like # InterPro IPR018060 HTH_AraC # InterPro IPR018062 HTH_AraC-typ_CS # InterPro IPR020449 Tscrpt_reg_HTH_AraC-type # KEGG_Brite ko03000 Transcription factors # Organism ENVY_ECOLI Escherichia coli (strain K12) # PATRIC 32116300 VBIEscCol129921_0590 # PIR D64789 D64789 # PRINTS PR00032 HTHARAC # PROSITE PS00041 HTH_ARAC_FAMILY_1 # PROSITE PS01124 HTH_ARAC_FAMILY_2 # Pfam PF12833 HTH_18 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ENVY_ECOLI Porin thermoregulatory protein EnvY # RefSeq NP_415098 NC_000913.3 # RefSeq WP_001177471 NZ_LN832404.1 # SIMILARITY Contains 1 HTH araC/xylS-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00593}. # SMART SM00342 HTH_ARAC # SUPFAM SSF46689 SSF46689 # eggNOG COG2207 LUCA BLAST swissprot:ENVY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ENVY_ECOLI BioCyc ECOL316407:JW0555-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0555-MONOMER BioCyc EcoCyc:PD00969 http://biocyc.org/getid?id=EcoCyc:PD00969 COG COG2207 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2207 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/17.2.800 http://dx.doi.org/10.1093/nar/17.2.800 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EMBL X13548 http://www.ebi.ac.uk/ena/data/view/X13548 EchoBASE EB0264 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0264 EcoGene EG10268 http://www.ecogene.org/geneInfo.php?eg_id=EG10268 EnsemblBacteria AAC73667 http://www.ensemblgenomes.org/id/AAC73667 EnsemblBacteria AAC73667 http://www.ensemblgenomes.org/id/AAC73667 EnsemblBacteria BAA35200 http://www.ensemblgenomes.org/id/BAA35200 EnsemblBacteria BAA35200 http://www.ensemblgenomes.org/id/BAA35200 EnsemblBacteria BAA35200 http://www.ensemblgenomes.org/id/BAA35200 EnsemblBacteria b0566 http://www.ensemblgenomes.org/id/b0566 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0000987 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000987 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0009266 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009266 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 GeneID 949114 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949114 HOGENOM HOG000127052 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000127052&db=HOGENOM6 InParanoid P10805 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P10805 IntAct P10805 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P10805* InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR018060 http://www.ebi.ac.uk/interpro/entry/IPR018060 InterPro IPR018062 http://www.ebi.ac.uk/interpro/entry/IPR018062 InterPro IPR020449 http://www.ebi.ac.uk/interpro/entry/IPR020449 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW0555 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0555 KEGG_Gene eco:b0566 http://www.genome.jp/dbget-bin/www_bget?eco:b0566 KEGG_Orthology KO:K11920 http://www.genome.jp/dbget-bin/www_bget?KO:K11920 OMA PHINRNI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PHINRNI PRINTS PR00032 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00032 PROSITE PS00041 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00041 PROSITE PS01124 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01124 PSORT swissprot:ENVY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ENVY_ECOLI PSORT-B swissprot:ENVY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ENVY_ECOLI PSORT2 swissprot:ENVY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ENVY_ECOLI Pfam PF12833 http://pfam.xfam.org/family/PF12833 Phobius swissprot:ENVY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ENVY_ECOLI PhylomeDB P10805 http://phylomedb.org/?seqid=P10805 ProteinModelPortal P10805 http://www.proteinmodelportal.org/query/uniprot/P10805 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2536924 http://www.ncbi.nlm.nih.gov/pubmed/2536924 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415098 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415098 RefSeq WP_001177471 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001177471 SMART SM00342 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00342 SMR P10805 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P10805 STRING 511145.b0566 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0566&targetmode=cogs STRING COG2207 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2207&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 UniProtKB ENVY_ECOLI http://www.uniprot.org/uniprot/ENVY_ECOLI UniProtKB-AC P10805 http://www.uniprot.org/uniprot/P10805 charge swissprot:ENVY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ENVY_ECOLI eggNOG COG2207 http://eggnogapi.embl.de/nog_data/html/tree/COG2207 epestfind swissprot:ENVY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ENVY_ECOLI garnier swissprot:ENVY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ENVY_ECOLI helixturnhelix swissprot:ENVY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ENVY_ECOLI hmoment swissprot:ENVY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ENVY_ECOLI iep swissprot:ENVY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ENVY_ECOLI inforesidue swissprot:ENVY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ENVY_ECOLI octanol swissprot:ENVY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ENVY_ECOLI pepcoil swissprot:ENVY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ENVY_ECOLI pepdigest swissprot:ENVY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ENVY_ECOLI pepinfo swissprot:ENVY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ENVY_ECOLI pepnet swissprot:ENVY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ENVY_ECOLI pepstats swissprot:ENVY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ENVY_ECOLI pepwheel swissprot:ENVY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ENVY_ECOLI pepwindow swissprot:ENVY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ENVY_ECOLI sigcleave swissprot:ENVY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ENVY_ECOLI ## Database ID URL or Descriptions # BioGrid 4262558 8 # EcoGene EG11765 yibI # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GOslim_component GO:0005886 plasma membrane # InterPro IPR011223 UCP028770 # Organism YIBI_ECOLI Escherichia coli (strain K12) # PATRIC 32122679 VBIEscCol129921_3716 # PIR S47819 S47819 # PIRSF PIRSF028770 UCP028770 # Pfam PF11742 DUF3302 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIBI_ECOLI Uncharacterized protein YibI # RefSeq NP_418055 NC_000913.3 # RefSeq WP_000479624 NZ_LN832404.1 # SIMILARITY To E.coli YiaW. {ECO 0000305}. # TCDB 9.B.32.1 the duf3302 or pfam11742 (yibi) family # eggNOG ENOG4105FP6 Bacteria # eggNOG ENOG4111NAV LUCA BLAST swissprot:YIBI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIBI_ECOLI BioCyc ECOL316407:JW3572-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3572-MONOMER BioCyc EcoCyc:EG11765-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11765-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19044 http://www.ebi.ac.uk/ena/data/view/L19044 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1715 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1715 EcoGene EG11765 http://www.ecogene.org/geneInfo.php?eg_id=EG11765 EnsemblBacteria AAC76622 http://www.ensemblgenomes.org/id/AAC76622 EnsemblBacteria AAC76622 http://www.ensemblgenomes.org/id/AAC76622 EnsemblBacteria BAE77695 http://www.ensemblgenomes.org/id/BAE77695 EnsemblBacteria BAE77695 http://www.ensemblgenomes.org/id/BAE77695 EnsemblBacteria BAE77695 http://www.ensemblgenomes.org/id/BAE77695 EnsemblBacteria b3598 http://www.ensemblgenomes.org/id/b3598 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 948109 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948109 HOGENOM HOG000279233 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000279233&db=HOGENOM6 InParanoid P32108 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32108 InterPro IPR011223 http://www.ebi.ac.uk/interpro/entry/IPR011223 KEGG_Gene ecj:JW3572 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3572 KEGG_Gene eco:b3598 http://www.genome.jp/dbget-bin/www_bget?eco:b3598 OMA WIWATIY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WIWATIY PSORT swissprot:YIBI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIBI_ECOLI PSORT-B swissprot:YIBI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIBI_ECOLI PSORT2 swissprot:YIBI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIBI_ECOLI Pfam PF11742 http://pfam.xfam.org/family/PF11742 Phobius swissprot:YIBI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIBI_ECOLI ProteinModelPortal P32108 http://www.proteinmodelportal.org/query/uniprot/P32108 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 8387990 http://www.ncbi.nlm.nih.gov/pubmed/8387990 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418055 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418055 RefSeq WP_000479624 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000479624 STRING 511145.b3598 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3598&targetmode=cogs TCDB 9.B.32.1 http://www.tcdb.org/search/result.php?tc=9.B.32.1 UniProtKB YIBI_ECOLI http://www.uniprot.org/uniprot/YIBI_ECOLI UniProtKB-AC P32108 http://www.uniprot.org/uniprot/P32108 charge swissprot:YIBI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIBI_ECOLI eggNOG ENOG4105FP6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FP6 eggNOG ENOG4111NAV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111NAV epestfind swissprot:YIBI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIBI_ECOLI garnier swissprot:YIBI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIBI_ECOLI helixturnhelix swissprot:YIBI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIBI_ECOLI hmoment swissprot:YIBI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIBI_ECOLI iep swissprot:YIBI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIBI_ECOLI inforesidue swissprot:YIBI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIBI_ECOLI octanol swissprot:YIBI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIBI_ECOLI pepcoil swissprot:YIBI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIBI_ECOLI pepdigest swissprot:YIBI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIBI_ECOLI pepinfo swissprot:YIBI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIBI_ECOLI pepnet swissprot:YIBI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIBI_ECOLI pepstats swissprot:YIBI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIBI_ECOLI pepwheel swissprot:YIBI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIBI_ECOLI pepwindow swissprot:YIBI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIBI_ECOLI sigcleave swissprot:YIBI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIBI_ECOLI ## Database ID URL or Descriptions # AltName RIHB_ECOLI Cytidine/uridine-specific hydrolase # BRENDA 3.2.2 2026 # BioGrid 4261071 3 # CATALYTIC ACTIVITY RIHB_ECOLI A pyrimidine nucleoside + H(2)O = D-ribose + a pyrimidine base. # COFACTOR Name=Ca(2+); Xref=ChEBI:CHEBI 29108; Note=Binds 1 Ca(2+) ion per monomer.; # EcoGene EG12030 rihB # FUNCTION RIHB_ECOLI Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively. Has a clear preference for cytidine over uridine. Strictly specific for ribonucleosides. Has a low but significant activity for the purine nucleoside xanthosine. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0005509 calcium ion binding; IDA:EcoCyc. # GO_function GO:0008477 purine nucleosidase activity; IBA:GO_Central. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0045437 uridine nucleosidase activity; IDA:EcoCyc. # GO_process GO:0006152 purine nucleoside catabolic process; IBA:GO_Central. # GO_process GO:0006206 pyrimidine nucleobase metabolic process; IEA:UniProtKB-HAMAP. # GO_process GO:0046133 pyrimidine ribonucleoside catabolic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.90.245.10 -; 1. # HAMAP MF_01433 Pyrim_hydro_RihB # IntAct P33022 5 # InterPro IPR001910 Inosine/uridine_hydrolase_dom # InterPro IPR015910 I/U_nuclsd_hydro_CS # InterPro IPR022977 Pyrim_hydro_RihB # InterPro IPR023186 Inosine/uridine_hydrolase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00240 Pyrimidine metabolism # Organism RIHB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR12304 PTHR12304 # PATRIC 32119673 VBIEscCol129921_2247 # PDB 1Q8F X-ray; 1.70 A; A/B/C/D=1-313 # PDB 3B9X X-ray; 2.30 A; A/B/C/D=1-313 # PIR A64985 A64985 # PROSITE PS01247 IUNH # Pfam PF01156 IU_nuc_hydro # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RIHB_ECOLI Pyrimidine-specific ribonucleoside hydrolase RihB # RefSeq NP_416667 NC_000913.3 # RefSeq WP_000415429 NZ_LN832404.1 # SIMILARITY Belongs to the IUNH family. RihB subfamily. {ECO 0000305}. # SUBUNIT Homotetramer. {ECO:0000269|PubMed 15130467}. # SUPFAM SSF53590 SSF53590 # eggNOG COG1957 LUCA # eggNOG ENOG4105DU0 Bacteria BLAST swissprot:RIHB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RIHB_ECOLI BioCyc ECOL316407:JW2149-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2149-MONOMER BioCyc EcoCyc:EG12030-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12030-MONOMER BioCyc MetaCyc:EG12030-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12030-MONOMER COG COG1957 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1957 DOI 10.1016/j.str.2004.03.018 http://dx.doi.org/10.1016/j.str.2004.03.018 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M008300200 http://dx.doi.org/10.1074/jbc.M008300200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.2.2.8 http://www.genome.jp/dbget-bin/www_bget?EC:3.2.2.8 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.2.2.8 http://enzyme.expasy.org/EC/3.2.2.8 EchoBASE EB1965 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1965 EcoGene EG12030 http://www.ecogene.org/geneInfo.php?eg_id=EG12030 EnsemblBacteria AAC75223 http://www.ensemblgenomes.org/id/AAC75223 EnsemblBacteria AAC75223 http://www.ensemblgenomes.org/id/AAC75223 EnsemblBacteria BAE76639 http://www.ensemblgenomes.org/id/BAE76639 EnsemblBacteria BAE76639 http://www.ensemblgenomes.org/id/BAE76639 EnsemblBacteria BAE76639 http://www.ensemblgenomes.org/id/BAE76639 EnsemblBacteria b2162 http://www.ensemblgenomes.org/id/b2162 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0005509 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509 GO_function GO:0008477 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008477 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0045437 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045437 GO_process GO:0006152 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006152 GO_process GO:0006206 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006206 GO_process GO:0046133 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046133 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.90.245.10 http://www.cathdb.info/version/latest/superfamily/3.90.245.10 GeneID 946646 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946646 HAMAP MF_01433 http://hamap.expasy.org/unirule/MF_01433 HOGENOM HOG000218839 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218839&db=HOGENOM6 InParanoid P33022 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33022 IntAct P33022 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33022* IntEnz 3.2.2.8 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.2.2.8 InterPro IPR001910 http://www.ebi.ac.uk/interpro/entry/IPR001910 InterPro IPR015910 http://www.ebi.ac.uk/interpro/entry/IPR015910 InterPro IPR022977 http://www.ebi.ac.uk/interpro/entry/IPR022977 InterPro IPR023186 http://www.ebi.ac.uk/interpro/entry/IPR023186 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2149 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2149 KEGG_Gene eco:b2162 http://www.genome.jp/dbget-bin/www_bget?eco:b2162 KEGG_Orthology KO:K10213 http://www.genome.jp/dbget-bin/www_bget?KO:K10213 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Reaction rn:R01245 http://www.genome.jp/dbget-bin/www_bget?rn:R01245 KEGG_Reaction rn:R01677 http://www.genome.jp/dbget-bin/www_bget?rn:R01677 KEGG_Reaction rn:R01770 http://www.genome.jp/dbget-bin/www_bget?rn:R01770 KEGG_Reaction rn:R02137 http://www.genome.jp/dbget-bin/www_bget?rn:R02137 OMA WIHGDNG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WIHGDNG PANTHER PTHR12304 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12304 PDB 1Q8F http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q8F PDB 3B9X http://www.ebi.ac.uk/pdbe-srv/view/entry/3B9X PDBsum 1Q8F http://www.ebi.ac.uk/pdbsum/1Q8F PDBsum 3B9X http://www.ebi.ac.uk/pdbsum/3B9X PROSITE PS01247 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01247 PSORT swissprot:RIHB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RIHB_ECOLI PSORT-B swissprot:RIHB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RIHB_ECOLI PSORT2 swissprot:RIHB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RIHB_ECOLI Pfam PF01156 http://pfam.xfam.org/family/PF01156 Phobius swissprot:RIHB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RIHB_ECOLI PhylomeDB P33022 http://phylomedb.org/?seqid=P33022 ProteinModelPortal P33022 http://www.proteinmodelportal.org/query/uniprot/P33022 PubMed 11027694 http://www.ncbi.nlm.nih.gov/pubmed/11027694 PubMed 15130467 http://www.ncbi.nlm.nih.gov/pubmed/15130467 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416667 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416667 RefSeq WP_000415429 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000415429 SMR P33022 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33022 STRING 511145.b2162 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2162&targetmode=cogs STRING COG1957 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1957&targetmode=cogs SUPFAM SSF53590 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53590 UniProtKB RIHB_ECOLI http://www.uniprot.org/uniprot/RIHB_ECOLI UniProtKB-AC P33022 http://www.uniprot.org/uniprot/P33022 charge swissprot:RIHB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RIHB_ECOLI eggNOG COG1957 http://eggnogapi.embl.de/nog_data/html/tree/COG1957 eggNOG ENOG4105DU0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DU0 epestfind swissprot:RIHB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RIHB_ECOLI garnier swissprot:RIHB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RIHB_ECOLI helixturnhelix swissprot:RIHB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RIHB_ECOLI hmoment swissprot:RIHB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RIHB_ECOLI iep swissprot:RIHB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RIHB_ECOLI inforesidue swissprot:RIHB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RIHB_ECOLI octanol swissprot:RIHB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RIHB_ECOLI pepcoil swissprot:RIHB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RIHB_ECOLI pepdigest swissprot:RIHB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RIHB_ECOLI pepinfo swissprot:RIHB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RIHB_ECOLI pepnet swissprot:RIHB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RIHB_ECOLI pepstats swissprot:RIHB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RIHB_ECOLI pepwheel swissprot:RIHB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RIHB_ECOLI pepwindow swissprot:RIHB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RIHB_ECOLI sigcleave swissprot:RIHB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RIHB_ECOLI ## Database ID URL or Descriptions # AltName CYDA_ECOLI Cytochrome bd-I oxidase subunit I # AltName CYDA_ECOLI Cytochrome d ubiquinol oxidase subunit I # BIOPHYSICOCHEMICAL PROPERTIES CYDA_ECOLI Kinetic parameters KM=0.1 mM for ubiquinol-1 {ECO 0000269|PubMed 6307994}; KM=0.28 mM for 2,3,5,6-tetramethyl-p-phenylenediamine {ECO 0000269|PubMed 6307994}; KM=0.68 mM for N,N,N',N'-tetramethyl-p-phenylenediamine {ECO 0000269|PubMed 6307994}; Vmax=383 umol/min/mg enzyme for ubiquinol-1 {ECO 0000269|PubMed 6307994}; Vmax=270 umol/min/mg enzyme for 2,3,5,6-tetramethyl-p- phenylenediamine {ECO 0000269|PubMed 6307994}; Vmax=126 umol/min/mg enzyme for N,N,N',N'-tetramethyl-p- phenylenediamine {ECO 0000269|PubMed 6307994}; Note=pH 7.0, 37 degrees Celsius.; # BRENDA 1.10.3.14 2026 # BioGrid 4263539 338 # CATALYTIC ACTIVITY CYDA_ECOLI 2 ubiquinol + O(2) + 4 H(+)(Side 1) = 2 ubiquinone + 2 H(2)O + 4 H(+)(Side 2). # COFACTOR Name=heme b; Xref=ChEBI:CHEBI 60344; Note=Binds 1 protoheme IX center (heme b558) per subunit.; # COFACTOR Name=heme b; Xref=ChEBI:CHEBI 60344; Note=Binds 1 protoheme IX center (heme b595, originally called cytochrome a1) per heterodimer, in conjunction with CydB.; # COFACTOR Name=heme d cis-diol; Xref=ChEBI:CHEBI 62814; Note=Binds 1 iron-chlorin (heme d or cytochrome d) per heterodimer, in conjunction with CydB.; # DISRUPTION PHENOTYPE CYDA_ECOLI A double cydA/cydB deletion shows increased sensitivity to reductant (beta-mercapoethanol). {ECO 0000269|PubMed 19542282, ECO 0000269|PubMed 21987791, ECO 0000269|PubMed 23749980}. # ENZYME REGULATION 90% inhibited by cyanide and 2-heptyl-4- hydroxyquinoline N-oxide, at 1 mM and 40 uM respectively. {ECO:0000269|PubMed 6307994}. # EcoGene EG10173 cydA # FUNCTION CYDA_ECOLI A terminal oxidase that produces a proton motive force by the vectorial transfer of protons across the inner membrane. It is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at low aeration. Generates a proton motive force using protons and electrons from opposite sides of the membrane to generate H(2)O, transferring 1 proton/electron. {ECO 0000269|PubMed 19542282, ECO 0000269|PubMed 21987791, ECO 0000269|PubMed 2656671, ECO 0000269|PubMed 6307994, ECO 0000269|PubMed 7577938}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_component GO:0070069 cytochrome complex; IDA:EcoCyc. # GO_function GO:0009055 electron carrier activity; IDA:EcoCyc. # GO_function GO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors; IDA:EcoCyc. # GO_function GO:0016682 oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor; IBA:GO_Central. # GO_function GO:0020037 heme binding; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006119 oxidative phosphorylation; IEA:UniProtKB-UniPathway. # GO_process GO:0019646 aerobic electron transport chain; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # INDUCTION Under conditions of low aeration, in stationary phase (at protein level). {ECO:0000269|PubMed 6307994}. # INTERACTION CYDA_ECOLI P0ABK2 cydB; NbExp=5; IntAct=EBI-906928, EBI-1213195; # IntAct P0ABJ9 4 # InterPro IPR002585 Cyt-d_ubiquinol_oxidase_su_1 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00190 Oxidative phosphorylation # KEGG_Pathway ko02020 Two-component system # Organism CYDA_ECOLI Escherichia coli (strain K12) # PATHWAY CYDA_ECOLI Energy metabolism; oxidative phosphorylation. # PATRIC 32116663 VBIEscCol129921_0764 # PTM CYDA_ECOLI The N-terminus is blocked. # Pfam PF01654 Cyt_bd_oxida_I # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CYDA_ECOLI Cytochrome bd-I ubiquinol oxidase subunit 1 # RefSeq NP_415261 NC_000913.3 # RefSeq WP_000884361 NZ_LN832404.1 # SIMILARITY Belongs to the cytochrome ubiquinol oxidase subunit 1 family. {ECO 0000305}. # SUBCELLULAR LOCATION CYDA_ECOLI Cell inner membrane {ECO 0000269|PubMed 15013751, ECO 0000269|PubMed 16079137}; Multi- pass membrane protein {ECO 0000269|PubMed 15013751, ECO 0000269|PubMed 16079137}. # SUBUNIT CYDA_ECOLI Heterodimer of subunits I and II. Probably interacts with CydX, and overexpressed AppX. {ECO 0000269|PubMed 16079137, ECO 0000269|PubMed 23749980, ECO 0000269|PubMed 3281937, ECO 0000269|PubMed 6307994}. # TCDB 3.D.4.3 the proton-translocating cytochrome oxidase (cox) superfamily # eggNOG COG1271 LUCA # eggNOG ENOG4105C4M Bacteria BLAST swissprot:CYDA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CYDA_ECOLI BioCyc ECOL316407:JW0722-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0722-MONOMER BioCyc EcoCyc:CYDA-MONOMER http://biocyc.org/getid?id=EcoCyc:CYDA-MONOMER BioCyc MetaCyc:CYDA-MONOMER http://biocyc.org/getid?id=MetaCyc:CYDA-MONOMER COG COG1271 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1271 DIP DIP-36181N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36181N DOI 10.1016/S0014-5793(04)00125-5 http://dx.doi.org/10.1016/S0014-5793(04)00125-5 DOI 10.1016/j.bbabio.2011.06.016 http://dx.doi.org/10.1016/j.bbabio.2011.06.016 DOI 10.1021/bi00041a029 http://dx.doi.org/10.1021/bi00041a029 DOI 10.1021/bi00357a002 http://dx.doi.org/10.1021/bi00357a002 DOI 10.1021/bi00357a003 http://dx.doi.org/10.1021/bi00357a003 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.1108217108 http://dx.doi.org/10.1073/pnas.1108217108 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1991.tb02097.x http://dx.doi.org/10.1111/j.1365-2958.1991.tb02097.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00324-13 http://dx.doi.org/10.1128/JB.00324-13 DOI 10.1128/JB.00562-09 http://dx.doi.org/10.1128/JB.00562-09 EC_number EC:1.10.3.14 http://www.genome.jp/dbget-bin/www_bget?EC:1.10.3.14 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J03939 http://www.ebi.ac.uk/ena/data/view/J03939 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.10.3.14 http://enzyme.expasy.org/EC/1.10.3.14 EchoBASE EB0170 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0170 EcoGene EG10173 http://www.ecogene.org/geneInfo.php?eg_id=EG10173 EnsemblBacteria AAC73827 http://www.ensemblgenomes.org/id/AAC73827 EnsemblBacteria AAC73827 http://www.ensemblgenomes.org/id/AAC73827 EnsemblBacteria BAA35399 http://www.ensemblgenomes.org/id/BAA35399 EnsemblBacteria BAA35399 http://www.ensemblgenomes.org/id/BAA35399 EnsemblBacteria BAA35399 http://www.ensemblgenomes.org/id/BAA35399 EnsemblBacteria b0733 http://www.ensemblgenomes.org/id/b0733 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0070069 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070069 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0016679 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016679 GO_function GO:0016682 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016682 GO_function GO:0020037 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0020037 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006119 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006119 GO_process GO:0019646 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019646 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 945341 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945341 HOGENOM HOG000084938 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000084938&db=HOGENOM6 InParanoid P0ABJ9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABJ9 IntAct P0ABJ9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABJ9* IntEnz 1.10.3.14 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.10.3.14 InterPro IPR002585 http://www.ebi.ac.uk/interpro/entry/IPR002585 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0722 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0722 KEGG_Gene eco:b0733 http://www.genome.jp/dbget-bin/www_bget?eco:b0733 KEGG_Orthology KO:K00425 http://www.genome.jp/dbget-bin/www_bget?KO:K00425 KEGG_Pathway ko00190 http://www.genome.jp/kegg-bin/show_pathway?ko00190 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA GWDRFSK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GWDRFSK PSORT swissprot:CYDA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CYDA_ECOLI PSORT-B swissprot:CYDA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CYDA_ECOLI PSORT2 swissprot:CYDA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CYDA_ECOLI Pfam PF01654 http://pfam.xfam.org/family/PF01654 Phobius swissprot:CYDA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CYDA_ECOLI PhylomeDB P0ABJ9 http://phylomedb.org/?seqid=P0ABJ9 ProteinModelPortal P0ABJ9 http://www.proteinmodelportal.org/query/uniprot/P0ABJ9 PubMed 15013751 http://www.ncbi.nlm.nih.gov/pubmed/15013751 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1689724 http://www.ncbi.nlm.nih.gov/pubmed/1689724 PubMed 1724280 http://www.ncbi.nlm.nih.gov/pubmed/1724280 PubMed 19542282 http://www.ncbi.nlm.nih.gov/pubmed/19542282 PubMed 21756872 http://www.ncbi.nlm.nih.gov/pubmed/21756872 PubMed 21987791 http://www.ncbi.nlm.nih.gov/pubmed/21987791 PubMed 23749980 http://www.ncbi.nlm.nih.gov/pubmed/23749980 PubMed 2656671 http://www.ncbi.nlm.nih.gov/pubmed/2656671 PubMed 2843510 http://www.ncbi.nlm.nih.gov/pubmed/2843510 PubMed 3013298 http://www.ncbi.nlm.nih.gov/pubmed/3013298 PubMed 3013299 http://www.ncbi.nlm.nih.gov/pubmed/3013299 PubMed 3138232 http://www.ncbi.nlm.nih.gov/pubmed/3138232 PubMed 3281937 http://www.ncbi.nlm.nih.gov/pubmed/3281937 PubMed 6307994 http://www.ncbi.nlm.nih.gov/pubmed/6307994 PubMed 7577938 http://www.ncbi.nlm.nih.gov/pubmed/7577938 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415261 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415261 RefSeq WP_000884361 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000884361 STRING 511145.b0733 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0733&targetmode=cogs STRING COG1271 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1271&targetmode=cogs TCDB 3.D.4.3 http://www.tcdb.org/search/result.php?tc=3.D.4.3 UniProtKB CYDA_ECOLI http://www.uniprot.org/uniprot/CYDA_ECOLI UniProtKB-AC P0ABJ9 http://www.uniprot.org/uniprot/P0ABJ9 charge swissprot:CYDA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CYDA_ECOLI eggNOG COG1271 http://eggnogapi.embl.de/nog_data/html/tree/COG1271 eggNOG ENOG4105C4M http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C4M epestfind swissprot:CYDA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CYDA_ECOLI garnier swissprot:CYDA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CYDA_ECOLI helixturnhelix swissprot:CYDA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CYDA_ECOLI hmoment swissprot:CYDA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CYDA_ECOLI iep swissprot:CYDA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CYDA_ECOLI inforesidue swissprot:CYDA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CYDA_ECOLI octanol swissprot:CYDA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CYDA_ECOLI pepcoil swissprot:CYDA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CYDA_ECOLI pepdigest swissprot:CYDA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CYDA_ECOLI pepinfo swissprot:CYDA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CYDA_ECOLI pepnet swissprot:CYDA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CYDA_ECOLI pepstats swissprot:CYDA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CYDA_ECOLI pepwheel swissprot:CYDA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CYDA_ECOLI pepwindow swissprot:CYDA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CYDA_ECOLI sigcleave swissprot:CYDA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CYDA_ECOLI ## Database ID URL or Descriptions # BioGrid 4263262 98 # EcoGene EG10093 asnC # FUNCTION ASNC_ECOLI Activator of asnA transcription; autogenous regulator of its own transcription; and repressor of the expression of gidA at a post-transcriptional level. {ECO 0000269|PubMed 2836709, ECO 0000269|PubMed 2864330, ECO 0000269|PubMed 3909107}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IDA:EcoCyc. # GO_function GO:0016597 amino acid binding; IPI:EcoCyc. # GO_function GO:0043565 sequence-specific DNA binding; ISS:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0043200 response to amino acid; IDA:EcoCyc. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # Gene3D 3.30.70.920 -; 1. # INTERACTION ASNC_ECOLI P31658 hchA; NbExp=2; IntAct=EBI-1133670, EBI-909144; # InterPro IPR000485 AsnC-type_HTH_dom # InterPro IPR011008 Dimeric_a/b-barrel # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR019885 Tscrpt_reg_HTH_AsnC-type_CS # InterPro IPR019887 Tscrpt_reg_AsnC/Lrp_C # InterPro IPR019888 Tscrpt_reg_AsnC-typ # KEGG_Brite ko03000 Transcription factors # Organism ASNC_ECOLI Escherichia coli (strain K12) # PATRIC 32122985 VBIEscCol129921_3868 # PDB 2CG4 X-ray; 2.40 A; A/B=1-152 # PIR A04434 QQECE1 # PRINTS PR00033 HTHASNC # PROSITE PS00519 HTH_ASNC_1 # PROSITE PS50956 HTH_ASNC_2 # Pfam PF01037 AsnC_trans_reg # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ASNC_ECOLI Regulatory protein AsnC # RefSeq NP_418199 NC_000913.3 # RefSeq WP_000432970 NZ_LN832404.1 # RefSeq YP_006952152 NC_019049.1 # SIMILARITY Contains 1 HTH asnC-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00319}. # SMART SM00344 HTH_ASNC # SUPFAM SSF46785 SSF46785 # SUPFAM SSF54909 SSF54909 # eggNOG COG1522 LUCA # eggNOG ENOG4108VVK Bacteria BLAST swissprot:ASNC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ASNC_ECOLI BioCyc ECOL316407:JW3721-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3721-MONOMER BioCyc EcoCyc:PD00250 http://biocyc.org/getid?id=EcoCyc:PD00250 COG COG1522 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1522 DIP DIP-9178N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9178N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1007/BF00322450 http://dx.doi.org/10.1007/BF00322450 DOI 10.1016/0378-1119(83)90087-2 http://dx.doi.org/10.1016/0378-1119(83)90087-2 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/13.24.8797 http://dx.doi.org/10.1093/nar/13.24.8797 DOI 10.1093/nar/9.18.4669 http://dx.doi.org/10.1093/nar/9.18.4669 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K00826 http://www.ebi.ac.uk/ena/data/view/K00826 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00263 http://www.ebi.ac.uk/ena/data/view/V00263 EchoBASE EB0091 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0091 EcoGene EG10093 http://www.ecogene.org/geneInfo.php?eg_id=EG10093 EnsemblBacteria AAC76766 http://www.ensemblgenomes.org/id/AAC76766 EnsemblBacteria AAC76766 http://www.ensemblgenomes.org/id/AAC76766 EnsemblBacteria BAE77545 http://www.ensemblgenomes.org/id/BAE77545 EnsemblBacteria BAE77545 http://www.ensemblgenomes.org/id/BAE77545 EnsemblBacteria BAE77545 http://www.ensemblgenomes.org/id/BAE77545 EnsemblBacteria b3743 http://www.ensemblgenomes.org/id/b3743 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0016597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016597 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0043200 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043200 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 3.30.70.920 http://www.cathdb.info/version/latest/superfamily/3.30.70.920 GeneID 13909070 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13909070 GeneID 948259 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948259 HOGENOM HOG000115326 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000115326&db=HOGENOM6 InParanoid P0ACI6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACI6 IntAct P0ACI6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACI6* InterPro IPR000485 http://www.ebi.ac.uk/interpro/entry/IPR000485 InterPro IPR011008 http://www.ebi.ac.uk/interpro/entry/IPR011008 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR019885 http://www.ebi.ac.uk/interpro/entry/IPR019885 InterPro IPR019887 http://www.ebi.ac.uk/interpro/entry/IPR019887 InterPro IPR019888 http://www.ebi.ac.uk/interpro/entry/IPR019888 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW3721 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3721 KEGG_Gene eco:b3743 http://www.genome.jp/dbget-bin/www_bget?eco:b3743 KEGG_Orthology KO:K03718 http://www.genome.jp/dbget-bin/www_bget?KO:K03718 OMA LCRDNEH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LCRDNEH PDB 2CG4 http://www.ebi.ac.uk/pdbe-srv/view/entry/2CG4 PDBsum 2CG4 http://www.ebi.ac.uk/pdbsum/2CG4 PRINTS PR00033 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00033 PROSITE PS00519 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00519 PROSITE PS50956 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50956 PSORT swissprot:ASNC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ASNC_ECOLI PSORT-B swissprot:ASNC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ASNC_ECOLI PSORT2 swissprot:ASNC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ASNC_ECOLI Pfam PF01037 http://pfam.xfam.org/family/PF01037 Phobius swissprot:ASNC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ASNC_ECOLI PhylomeDB P0ACI6 http://phylomedb.org/?seqid=P0ACI6 ProteinModelPortal P0ACI6 http://www.proteinmodelportal.org/query/uniprot/P0ACI6 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2836709 http://www.ncbi.nlm.nih.gov/pubmed/2836709 PubMed 2864330 http://www.ncbi.nlm.nih.gov/pubmed/2864330 PubMed 3909107 http://www.ncbi.nlm.nih.gov/pubmed/3909107 PubMed 6117826 http://www.ncbi.nlm.nih.gov/pubmed/6117826 PubMed 6357950 http://www.ncbi.nlm.nih.gov/pubmed/6357950 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418199 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418199 RefSeq WP_000432970 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000432970 RefSeq YP_006952152 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_006952152 SMART SM00344 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00344 SMR P0ACI6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACI6 STRING 511145.b3743 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3743&targetmode=cogs STRING COG1522 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1522&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SUPFAM SSF54909 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54909 UniProtKB ASNC_ECOLI http://www.uniprot.org/uniprot/ASNC_ECOLI UniProtKB-AC P0ACI6 http://www.uniprot.org/uniprot/P0ACI6 charge swissprot:ASNC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ASNC_ECOLI eggNOG COG1522 http://eggnogapi.embl.de/nog_data/html/tree/COG1522 eggNOG ENOG4108VVK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108VVK epestfind swissprot:ASNC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ASNC_ECOLI garnier swissprot:ASNC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ASNC_ECOLI helixturnhelix swissprot:ASNC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ASNC_ECOLI hmoment swissprot:ASNC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ASNC_ECOLI iep swissprot:ASNC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ASNC_ECOLI inforesidue swissprot:ASNC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ASNC_ECOLI octanol swissprot:ASNC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ASNC_ECOLI pepcoil swissprot:ASNC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ASNC_ECOLI pepdigest swissprot:ASNC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ASNC_ECOLI pepinfo swissprot:ASNC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ASNC_ECOLI pepnet swissprot:ASNC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ASNC_ECOLI pepstats swissprot:ASNC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ASNC_ECOLI pepwheel swissprot:ASNC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ASNC_ECOLI pepwindow swissprot:ASNC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ASNC_ECOLI sigcleave swissprot:ASNC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ASNC_ECOLI ## Database ID URL or Descriptions # BioGrid 4260558 15 # CDD cd06170 LuxR_C_like # EcoGene EG11609 evgA # FUNCTION EVGA_ECOLI Member of the two-component regulatory system EvgS/EvgA. Regulates the expression of emrKY operon and yfdX. Seems also to control expression of at least one other multidrug efflux operon. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0043565 sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0000160 phosphorelay signal transduction system; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # INTERACTION EVGA_ECOLI P0AFB8 glnG; NbExp=3; IntAct=EBI-548694, EBI-1113197; P45577 proQ; NbExp=3; IntAct=EBI-548694, EBI-8767901; # IntAct P0ACZ4 15 # InterPro IPR000792 Tscrpt_reg_LuxR_C # InterPro IPR001789 Sig_transdc_resp-reg_receiver # InterPro IPR011006 CheY-like_superfamily # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR016032 Sig_transdc_resp-reg_C-effctor # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02022 M00477 EvgS-EvgA (acid and drug tolerance) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # KEGG_Pathway ko05133 Pertussis # MASS SPECTROMETRY Mass=22693; Method=MALDI; Range=1-204; Evidence={ECO:0000269|PubMed 10825546}; # Organism EVGA_ECOLI Escherichia coli (strain K12) # PATRIC 32120117 VBIEscCol129921_2467 # PDB 3F6C X-ray; 1.45 A; A/B=2-133 # PIR JU0220 JU0220 # PRINTS PR00038 HTHLUXR # PROSITE PS00622 HTH_LUXR_1 # PROSITE PS50043 HTH_LUXR_2 # PROSITE PS50110 RESPONSE_REGULATORY # PTM EVGA_ECOLI Phosphorylated by EvgS. # Pfam PF00072 Response_reg # Pfam PF00196 GerE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EVGA_ECOLI Positive transcription regulator EvgA # RefSeq NP_416870 NC_000913.3 # RefSeq WP_000991370 NZ_LN832404.1 # SIMILARITY Contains 1 HTH luxR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00411}. # SIMILARITY Contains 1 response regulatory domain. {ECO:0000255|PROSITE-ProRule PRU00169}. # SMART SM00421 HTH_LUXR # SMART SM00448 REC # SUBCELLULAR LOCATION EVGA_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT EVGA_ECOLI Homodimer. # SUPFAM SSF46894 SSF46894 # SUPFAM SSF52172 SSF52172 # eggNOG ENOG4108WQH Bacteria # eggNOG ENOG4111M1G LUCA BLAST swissprot:EVGA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EVGA_ECOLI BioCyc ECOL316407:JW2366-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2366-MONOMER BioCyc EcoCyc:EVGA-MONOMER http://biocyc.org/getid?id=EcoCyc:EVGA-MONOMER COG COG2197 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2197 DIP DIP-48087N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48087N DOI 10.1016/0378-1119(94)90733-1 http://dx.doi.org/10.1016/0378-1119(94)90733-1 DOI 10.1016/S0167-4838(00)00052-2 http://dx.doi.org/10.1016/S0167-4838(00)00052-2 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1998.00716.x http://dx.doi.org/10.1046/j.1365-2958.1998.00716.x DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.183.4.1455-1458.2001 http://dx.doi.org/10.1128/JB.183.4.1455-1458.2001 DOI 10.1271/bbb.64.1203 http://dx.doi.org/10.1271/bbb.64.1203 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D11142 http://www.ebi.ac.uk/ena/data/view/D11142 EMBL D14008 http://www.ebi.ac.uk/ena/data/view/D14008 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1566 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1566 EcoGene EG11609 http://www.ecogene.org/geneInfo.php?eg_id=EG11609 EnsemblBacteria AAC75428 http://www.ensemblgenomes.org/id/AAC75428 EnsemblBacteria AAC75428 http://www.ensemblgenomes.org/id/AAC75428 EnsemblBacteria BAA16240 http://www.ensemblgenomes.org/id/BAA16240 EnsemblBacteria BAA16240 http://www.ensemblgenomes.org/id/BAA16240 EnsemblBacteria BAA16240 http://www.ensemblgenomes.org/id/BAA16240 EnsemblBacteria b2369 http://www.ensemblgenomes.org/id/b2369 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 946841 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946841 HOGENOM HOG000034813 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000034813&db=HOGENOM6 InParanoid P0ACZ4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACZ4 IntAct P0ACZ4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACZ4* InterPro IPR000792 http://www.ebi.ac.uk/interpro/entry/IPR000792 InterPro IPR001789 http://www.ebi.ac.uk/interpro/entry/IPR001789 InterPro IPR011006 http://www.ebi.ac.uk/interpro/entry/IPR011006 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR016032 http://www.ebi.ac.uk/interpro/entry/IPR016032 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW2366 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2366 KEGG_Gene eco:b2369 http://www.genome.jp/dbget-bin/www_bget?eco:b2369 KEGG_Orthology KO:K07690 http://www.genome.jp/dbget-bin/www_bget?KO:K07690 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 KEGG_Pathway ko05133 http://www.genome.jp/kegg-bin/show_pathway?ko05133 MINT MINT-1282623 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1282623 OMA PNTIKTH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PNTIKTH PDB 3F6C http://www.ebi.ac.uk/pdbe-srv/view/entry/3F6C PDBsum 3F6C http://www.ebi.ac.uk/pdbsum/3F6C PRINTS PR00038 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00038 PROSITE PS00622 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00622 PROSITE PS50043 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50043 PROSITE PS50110 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50110 PSORT swissprot:EVGA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EVGA_ECOLI PSORT-B swissprot:EVGA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EVGA_ECOLI PSORT2 swissprot:EVGA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EVGA_ECOLI Pfam PF00072 http://pfam.xfam.org/family/PF00072 Pfam PF00196 http://pfam.xfam.org/family/PF00196 Phobius swissprot:EVGA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EVGA_ECOLI PhylomeDB P0ACZ4 http://phylomedb.org/?seqid=P0ACZ4 ProteinModelPortal P0ACZ4 http://www.proteinmodelportal.org/query/uniprot/P0ACZ4 PubMed 10825546 http://www.ncbi.nlm.nih.gov/pubmed/10825546 PubMed 10923791 http://www.ncbi.nlm.nih.gov/pubmed/10923791 PubMed 11157960 http://www.ncbi.nlm.nih.gov/pubmed/11157960 PubMed 1289796 http://www.ncbi.nlm.nih.gov/pubmed/1289796 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8125343 http://www.ncbi.nlm.nih.gov/pubmed/8125343 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9535079 http://www.ncbi.nlm.nih.gov/pubmed/9535079 RefSeq NP_416870 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416870 RefSeq WP_000991370 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000991370 SMART SM00421 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00421 SMART SM00448 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00448 SMR P0ACZ4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACZ4 STRING 511145.b2369 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2369&targetmode=cogs STRING COG2197 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2197&targetmode=cogs SUPFAM SSF46894 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46894 SUPFAM SSF52172 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52172 UniProtKB EVGA_ECOLI http://www.uniprot.org/uniprot/EVGA_ECOLI UniProtKB-AC P0ACZ4 http://www.uniprot.org/uniprot/P0ACZ4 charge swissprot:EVGA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EVGA_ECOLI eggNOG ENOG4108WQH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108WQH eggNOG ENOG4111M1G http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111M1G epestfind swissprot:EVGA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EVGA_ECOLI garnier swissprot:EVGA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EVGA_ECOLI helixturnhelix swissprot:EVGA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EVGA_ECOLI hmoment swissprot:EVGA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EVGA_ECOLI iep swissprot:EVGA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EVGA_ECOLI inforesidue swissprot:EVGA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EVGA_ECOLI octanol swissprot:EVGA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EVGA_ECOLI pepcoil swissprot:EVGA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EVGA_ECOLI pepdigest swissprot:EVGA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EVGA_ECOLI pepinfo swissprot:EVGA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EVGA_ECOLI pepnet swissprot:EVGA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EVGA_ECOLI pepstats swissprot:EVGA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EVGA_ECOLI pepwheel swissprot:EVGA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EVGA_ECOLI pepwindow swissprot:EVGA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EVGA_ECOLI sigcleave swissprot:EVGA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EVGA_ECOLI ## Database ID URL or Descriptions # CDD cd03218 ABC_YhbG # DISRUPTION PHENOTYPE Results in an earlier growth arrest and onset of cell lethality. {ECO:0000269|PubMed 16765569}. # EcoGene EG11680 lptB # FUNCTION LPTB_ECOLI Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system. {ECO 0000269|PubMed 16765569, ECO 0000269|PubMed 17056748, ECO 0000269|PubMed 18424520}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0015437 lipopolysaccharide-transporting ATPase activity; IDA:EcoCyc. # GO_function GO:0032403 protein complex binding; IDA:EcoCyc. # GO_process GO:0015920 lipopolysaccharide transport; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # Gene3D 3.40.50.300 -; 1. # INDUCTION Transcriptionally regulated by sigma-E factor. {ECO:0000269|PubMed 17056748}. # IntAct P0A9V1 4 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # InterPro IPR030921 LPS_export_LptB # InterPro IPR032823 BCA_ABC_TP_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00320 Lipopolysaccharide export system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism LPTB_ECOLI Escherichia coli (strain K12) # PATRIC 32121822 VBIEscCol129921_3295 # PDB 4P31 X-ray; 2.05 A; A/B=2-241 # PDB 4P32 X-ray; 1.55 A; A/B=2-241 # PDB 4P33 X-ray; 1.65 A; A/B=2-241 # PIR C65111 C65111 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # Pfam PF00005 ABC_tran # Pfam PF12399 BCA_ABC_TP_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LPTB_ECOLI Lipopolysaccharide export system ATP-binding protein LptB # RefSeq NP_417668 NC_000913.3 # RefSeq WP_000224099 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. Outer membrane lipopolysaccharide export (TC 1.B.42) family. {ECO 0000305}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA # SUBCELLULAR LOCATION LPTB_ECOLI Cytoplasm {ECO 0000269|PubMed 16079137}. Cell inner membrane {ECO 0000269|PubMed 16079137}; Peripheral membrane protein {ECO 0000269|PubMed 16079137}; Cytoplasmic side {ECO 0000269|PubMed 16079137}. # SUBUNIT Component of the lipopolysaccharide transport and assembly complex. The LptBFG transporter is composed of two ATP- binding proteins (LptB) and two transmembrane proteins (LptF and LptG). {ECO:0000269|PubMed 19500581}. # SUPFAM SSF52540 SSF52540 # TCDB 1.B.42.1 the outer membrane lipopolysaccharide export porin (lps-ep) family # TIGRFAMs TIGR04406 LPS_export_lptB # eggNOG COG1137 LUCA # eggNOG ENOG4108IUZ Bacteria BLAST swissprot:LPTB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LPTB_ECOLI BioCyc ECOL316407:JW3168-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3168-MONOMER BioCyc EcoCyc:YHBG-MONOMER http://biocyc.org/getid?id=EcoCyc:YHBG-MONOMER BioCyc MetaCyc:YHBG-MONOMER http://biocyc.org/getid?id=MetaCyc:YHBG-MONOMER COG COG1137 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1137 DIP DIP-31876N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31876N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1016/j.febslet.2009.05.051 http://dx.doi.org/10.1016/j.febslet.2009.05.051 DOI 10.1016/j.resmic.2005.11.014 http://dx.doi.org/10.1016/j.resmic.2005.11.014 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.270.9.4822 http://dx.doi.org/10.1074/jbc.270.9.4822 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00270-08 http://dx.doi.org/10.1128/JB.00270-08 DOI 10.1128/JB.01126-06 http://dx.doi.org/10.1128/JB.01126-06 EC_number EC:3.6.3.- http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D12938 http://www.ebi.ac.uk/ena/data/view/D12938 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U12684 http://www.ebi.ac.uk/ena/data/view/U12684 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 3.6.3.- http://enzyme.expasy.org/EC/3.6.3.- EchoBASE EB1631 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1631 EcoGene EG11680 http://www.ecogene.org/geneInfo.php?eg_id=EG11680 EnsemblBacteria AAC76233 http://www.ensemblgenomes.org/id/AAC76233 EnsemblBacteria AAC76233 http://www.ensemblgenomes.org/id/AAC76233 EnsemblBacteria BAE77245 http://www.ensemblgenomes.org/id/BAE77245 EnsemblBacteria BAE77245 http://www.ensemblgenomes.org/id/BAE77245 EnsemblBacteria BAE77245 http://www.ensemblgenomes.org/id/BAE77245 EnsemblBacteria b3201 http://www.ensemblgenomes.org/id/b3201 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0015437 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015437 GO_function GO:0032403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032403 GO_process GO:0015920 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015920 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947725 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947725 InParanoid P0A9V1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9V1 IntAct P0A9V1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9V1* IntEnz 3.6.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3 InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR030921 http://www.ebi.ac.uk/interpro/entry/IPR030921 InterPro IPR032823 http://www.ebi.ac.uk/interpro/entry/IPR032823 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3168 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3168 KEGG_Gene eco:b3201 http://www.genome.jp/dbget-bin/www_bget?eco:b3201 KEGG_Orthology KO:K06861 http://www.genome.jp/dbget-bin/www_bget?KO:K06861 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 MINT MINT-7137019 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-7137019 OMA TIFYMIT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TIFYMIT PDB 4P31 http://www.ebi.ac.uk/pdbe-srv/view/entry/4P31 PDB 4P32 http://www.ebi.ac.uk/pdbe-srv/view/entry/4P32 PDB 4P33 http://www.ebi.ac.uk/pdbe-srv/view/entry/4P33 PDBsum 4P31 http://www.ebi.ac.uk/pdbsum/4P31 PDBsum 4P32 http://www.ebi.ac.uk/pdbsum/4P32 PDBsum 4P33 http://www.ebi.ac.uk/pdbsum/4P33 PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:LPTB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LPTB_ECOLI PSORT-B swissprot:LPTB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LPTB_ECOLI PSORT2 swissprot:LPTB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LPTB_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Pfam PF12399 http://pfam.xfam.org/family/PF12399 Phobius swissprot:LPTB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LPTB_ECOLI PhylomeDB P0A9V1 http://phylomedb.org/?seqid=P0A9V1 ProteinModelPortal P0A9V1 http://www.proteinmodelportal.org/query/uniprot/P0A9V1 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16765569 http://www.ncbi.nlm.nih.gov/pubmed/16765569 PubMed 17056748 http://www.ncbi.nlm.nih.gov/pubmed/17056748 PubMed 18424520 http://www.ncbi.nlm.nih.gov/pubmed/18424520 PubMed 19500581 http://www.ncbi.nlm.nih.gov/pubmed/19500581 PubMed 7876255 http://www.ncbi.nlm.nih.gov/pubmed/7876255 PubMed 8444818 http://www.ncbi.nlm.nih.gov/pubmed/8444818 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_417668 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417668 RefSeq WP_000224099 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000224099 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P0A9V1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9V1 STRING 511145.b3201 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3201&targetmode=cogs STRING COG1137 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1137&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 1.B.42.1 http://www.tcdb.org/search/result.php?tc=1.B.42.1 TIGRFAMs TIGR04406 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR04406 UniProtKB LPTB_ECOLI http://www.uniprot.org/uniprot/LPTB_ECOLI UniProtKB-AC P0A9V1 http://www.uniprot.org/uniprot/P0A9V1 charge swissprot:LPTB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LPTB_ECOLI eggNOG COG1137 http://eggnogapi.embl.de/nog_data/html/tree/COG1137 eggNOG ENOG4108IUZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108IUZ epestfind swissprot:LPTB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LPTB_ECOLI garnier swissprot:LPTB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LPTB_ECOLI helixturnhelix swissprot:LPTB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LPTB_ECOLI hmoment swissprot:LPTB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LPTB_ECOLI iep swissprot:LPTB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LPTB_ECOLI inforesidue swissprot:LPTB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LPTB_ECOLI octanol swissprot:LPTB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LPTB_ECOLI pepcoil swissprot:LPTB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LPTB_ECOLI pepdigest swissprot:LPTB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LPTB_ECOLI pepinfo swissprot:LPTB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LPTB_ECOLI pepnet swissprot:LPTB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LPTB_ECOLI pepstats swissprot:LPTB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LPTB_ECOLI pepwheel swissprot:LPTB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LPTB_ECOLI pepwindow swissprot:LPTB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LPTB_ECOLI sigcleave swissprot:LPTB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LPTB_ECOLI ## Database ID URL or Descriptions # AltName TAMB_ECOLI Autotransporter assembly factor TamB # BioGrid 4259309 311 # DISRUPTION PHENOTYPE Loss of localization of an exogenous protein, P1121 (ROD_p1121 of Citrobacter rodentium), to outer membranes, loss of cell aggregation when adhesins are over- expressed in a double tamA-tamB deletion mutant. {ECO:0000269|PubMed 22466966}. # EcoGene EG12514 tamB # FUNCTION TAMB_ECOLI Part of the translocation and assembly module (TAM) autotransporter assembly complex, which functions in translocation of autotransporters across the outer membrane. {ECO 0000269|PubMed 22466966}. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0097347 TAM protein secretion complex; IDA:EcoCyc. # GO_process GO:0009306 protein secretion; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043234 protein complex # GOslim_process GO:0006810 transport # IntAct P39321 6 # InterPro IPR007452 TamB # Organism TAMB_ECOLI Escherichia coli (strain K12) # PATRIC 32124019 VBIEscCol129921_4354 # PIR H65233 H65233 # Pfam PF04357 TamB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TAMB_ECOLI Translocation and assembly module TamB # RefSeq NP_418642 NC_000913.3 # RefSeq WP_000060911 NZ_CP014272.1 # SEQUENCE CAUTION Sequence=AAA97118.1; Type=Frameshift; Positions=493; Note=Produces two separate ORFs.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the TamB family. {ECO 0000305}. # SUBCELLULAR LOCATION TAMB_ECOLI Cell inner membrane {ECO 0000305|PubMed 22466966}; Single-pass membrane protein {ECO 0000305|PubMed 22466966}. # SUBUNIT Interacts with TamA. {ECO:0000269|PubMed 22466966}. # TCDB 9.B.22.1 the leukotoxin secretion morphogenesis protein c (morc) family # eggNOG COG2911 LUCA # eggNOG ENOG4105MA0 Bacteria BLAST swissprot:TAMB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TAMB_ECOLI BioCyc ECOL316407:JW4180-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4180-MONOMER BioCyc EcoCyc:G7875-MONOMER http://biocyc.org/getid?id=EcoCyc:G7875-MONOMER COG COG2911 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2911 DIP DIP-12942N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12942N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsmb.2261 http://dx.doi.org/10.1038/nsmb.2261 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2407 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2407 EcoGene EG12514 http://www.ecogene.org/geneInfo.php?eg_id=EG12514 EnsemblBacteria AAC77178 http://www.ensemblgenomes.org/id/AAC77178 EnsemblBacteria AAC77178 http://www.ensemblgenomes.org/id/AAC77178 EnsemblBacteria BAE78222 http://www.ensemblgenomes.org/id/BAE78222 EnsemblBacteria BAE78222 http://www.ensemblgenomes.org/id/BAE78222 EnsemblBacteria BAE78222 http://www.ensemblgenomes.org/id/BAE78222 EnsemblBacteria b4221 http://www.ensemblgenomes.org/id/b4221 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0097347 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097347 GO_process GO:0009306 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009306 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948742 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948742 HOGENOM HOG000127429 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000127429&db=HOGENOM6 InParanoid P39321 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39321 IntAct P39321 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39321* InterPro IPR007452 http://www.ebi.ac.uk/interpro/entry/IPR007452 KEGG_Gene ecj:JW4180 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4180 KEGG_Gene eco:b4221 http://www.genome.jp/dbget-bin/www_bget?eco:b4221 KEGG_Orthology KO:K09800 http://www.genome.jp/dbget-bin/www_bget?KO:K09800 OMA LFNAANR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LFNAANR PSORT swissprot:TAMB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TAMB_ECOLI PSORT-B swissprot:TAMB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TAMB_ECOLI PSORT2 swissprot:TAMB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TAMB_ECOLI Pfam PF04357 http://pfam.xfam.org/family/PF04357 Phobius swissprot:TAMB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TAMB_ECOLI PhylomeDB P39321 http://phylomedb.org/?seqid=P39321 ProteinModelPortal P39321 http://www.proteinmodelportal.org/query/uniprot/P39321 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22466966 http://www.ncbi.nlm.nih.gov/pubmed/22466966 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418642 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418642 RefSeq WP_000060911 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000060911 STRING 511145.b4221 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4221&targetmode=cogs STRING COG2911 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2911&targetmode=cogs TCDB 9.B.22.1 http://www.tcdb.org/search/result.php?tc=9.B.22.1 UniProtKB TAMB_ECOLI http://www.uniprot.org/uniprot/TAMB_ECOLI UniProtKB-AC P39321 http://www.uniprot.org/uniprot/P39321 charge swissprot:TAMB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TAMB_ECOLI eggNOG COG2911 http://eggnogapi.embl.de/nog_data/html/tree/COG2911 eggNOG ENOG4105MA0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105MA0 epestfind swissprot:TAMB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TAMB_ECOLI garnier swissprot:TAMB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TAMB_ECOLI helixturnhelix swissprot:TAMB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TAMB_ECOLI hmoment swissprot:TAMB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TAMB_ECOLI iep swissprot:TAMB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TAMB_ECOLI inforesidue swissprot:TAMB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TAMB_ECOLI octanol swissprot:TAMB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TAMB_ECOLI pepcoil swissprot:TAMB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TAMB_ECOLI pepdigest swissprot:TAMB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TAMB_ECOLI pepinfo swissprot:TAMB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TAMB_ECOLI pepnet swissprot:TAMB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TAMB_ECOLI pepstats swissprot:TAMB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TAMB_ECOLI pepwheel swissprot:TAMB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TAMB_ECOLI pepwindow swissprot:TAMB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TAMB_ECOLI sigcleave swissprot:TAMB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TAMB_ECOLI ## Database ID URL or Descriptions # AltName Ribosome-releasing factor {ECO:0000255|HAMAP-Rule MF_00040} # BioGrid 4259750 19 # CDD cd00520 RRF # EcoGene EG10335 frr # FUNCTION RRF_ECOLI Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. # GO_component GO:0005737 cytoplasm; IDA:EcoCyc. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0043023 ribosomal large subunit binding; IDA:EcoCyc. # GO_process GO:0002184 cytoplasmic translational termination; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0008150 biological_process # Gene3D 1.10.132.20 -; 1. # HAMAP MF_00040 RRF # INTERACTION RRF_ECOLI P0AD49 raiA; NbExp=4; IntAct=EBI-1114349, EBI-1129692; P0A8E1 ycfP; NbExp=2; IntAct=EBI-1114349, EBI-9129402; # IntAct P0A805 35 # InterPro IPR002661 Ribosome_recyc_fac # InterPro IPR023584 Ribosome_recyc_fac_dom # KEGG_Brite ko03012 Translation factors # Organism RRF_ECOLI Escherichia coli (strain K12) # PANTHER PTHR20982 PTHR20982 # PATRIC 32115453 VBIEscCol129921_0178 # PDB 1EK8 X-ray; 2.30 A; A=1-185 # PDB 1ISE X-ray; 2.20 A; A=1-185 # PDB 1Y69 X-ray; 3.33 A; 8=1-185 # PDB 1ZN0 EM; 15.50 A; A=1-185 # PDB 1ZN1 EM; 14.10 A; A=1-185 # PDB 2RDO EM; 9.10 A; 8=1-185 # PDB 4V9C X-ray; 3.30 A; CY=1-185 # PDB 4V9D X-ray; 3.00 A; AY=2-183 # PDB 4WOI X-ray; 3.00 A; AV=1-185 # PIR A34495 A34495 # Pfam PF01765 RRF # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Ribosome-recycling factor {ECO:0000255|HAMAP-Rule MF_00040} # RefSeq NP_414714 NC_000913.3 # RefSeq WP_000622418 NZ_LN832404.1 # SIMILARITY Belongs to the RRF family. {ECO:0000255|HAMAP- Rule MF_00040}. # SUBCELLULAR LOCATION RRF_ECOLI Cytoplasm. # SUPFAM SSF55194 SSF55194 # TIGRFAMs TIGR00496 frr # eggNOG COG0233 LUCA # eggNOG ENOG4108VCV Bacteria BLAST swissprot:RRF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RRF_ECOLI BioCyc ECOL316407:JW0167-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0167-MONOMER BioCyc EcoCyc:EG10335-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10335-MONOMER COG COG0233 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0233 DIP DIP-48120N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48120N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0401904101 http://dx.doi.org/10.1073/pnas.0401904101 DOI 10.1073/pnas.91.10.4249 http://dx.doi.org/10.1073/pnas.91.10.4249 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D13334 http://www.ebi.ac.uk/ena/data/view/D13334 EMBL J05113 http://www.ebi.ac.uk/ena/data/view/J05113 EMBL M69029 http://www.ebi.ac.uk/ena/data/view/M69029 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EchoBASE EB0331 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0331 EcoGene EG10335 http://www.ecogene.org/geneInfo.php?eg_id=EG10335 EnsemblBacteria AAC73283 http://www.ensemblgenomes.org/id/AAC73283 EnsemblBacteria AAC73283 http://www.ensemblgenomes.org/id/AAC73283 EnsemblBacteria BAB96748 http://www.ensemblgenomes.org/id/BAB96748 EnsemblBacteria BAB96748 http://www.ensemblgenomes.org/id/BAB96748 EnsemblBacteria BAB96748 http://www.ensemblgenomes.org/id/BAB96748 EnsemblBacteria b0172 http://www.ensemblgenomes.org/id/b0172 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0043023 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043023 GO_process GO:0002184 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002184 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.10.132.20 http://www.cathdb.info/version/latest/superfamily/1.10.132.20 GeneID 946122 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946122 HAMAP MF_00040 http://hamap.expasy.org/unirule/MF_00040 HOGENOM HOG000040143 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000040143&db=HOGENOM6 InParanoid P0A805 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A805 IntAct P0A805 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A805* InterPro IPR002661 http://www.ebi.ac.uk/interpro/entry/IPR002661 InterPro IPR023584 http://www.ebi.ac.uk/interpro/entry/IPR023584 KEGG_Brite ko03012 http://www.genome.jp/dbget-bin/www_bget?ko03012 KEGG_Gene ecj:JW0167 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0167 KEGG_Gene eco:b0172 http://www.genome.jp/dbget-bin/www_bget?eco:b0172 KEGG_Orthology KO:K02838 http://www.genome.jp/dbget-bin/www_bget?KO:K02838 MINT MINT-1308979 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1308979 OMA VQPWEKK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VQPWEKK PANTHER PTHR20982 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR20982 PDB 1EK8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1EK8 PDB 1ISE http://www.ebi.ac.uk/pdbe-srv/view/entry/1ISE PDB 1Y69 http://www.ebi.ac.uk/pdbe-srv/view/entry/1Y69 PDB 1ZN0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZN0 PDB 1ZN1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZN1 PDB 2RDO http://www.ebi.ac.uk/pdbe-srv/view/entry/2RDO PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDBsum 1EK8 http://www.ebi.ac.uk/pdbsum/1EK8 PDBsum 1ISE http://www.ebi.ac.uk/pdbsum/1ISE PDBsum 1Y69 http://www.ebi.ac.uk/pdbsum/1Y69 PDBsum 1ZN0 http://www.ebi.ac.uk/pdbsum/1ZN0 PDBsum 1ZN1 http://www.ebi.ac.uk/pdbsum/1ZN1 PDBsum 2RDO http://www.ebi.ac.uk/pdbsum/2RDO PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PSORT swissprot:RRF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RRF_ECOLI PSORT-B swissprot:RRF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RRF_ECOLI PSORT2 swissprot:RRF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RRF_ECOLI Pfam PF01765 http://pfam.xfam.org/family/PF01765 Phobius swissprot:RRF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RRF_ECOLI PhylomeDB P0A805 http://phylomedb.org/?seqid=P0A805 ProteinModelPortal P0A805 http://www.proteinmodelportal.org/query/uniprot/P0A805 PubMed 1447125 http://www.ncbi.nlm.nih.gov/pubmed/1447125 PubMed 15178758 http://www.ncbi.nlm.nih.gov/pubmed/15178758 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1860827 http://www.ncbi.nlm.nih.gov/pubmed/1860827 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 2684966 http://www.ncbi.nlm.nih.gov/pubmed/2684966 PubMed 8183897 http://www.ncbi.nlm.nih.gov/pubmed/8183897 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_414714 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414714 RefSeq WP_000622418 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000622418 SMR P0A805 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A805 STRING 511145.b0172 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0172&targetmode=cogs STRING COG0233 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0233&targetmode=cogs SUPFAM SSF55194 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55194 SWISS-2DPAGE P0A805 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A805 TIGRFAMs TIGR00496 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00496 UniProtKB RRF_ECOLI http://www.uniprot.org/uniprot/RRF_ECOLI UniProtKB-AC P0A805 http://www.uniprot.org/uniprot/P0A805 charge swissprot:RRF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RRF_ECOLI eggNOG COG0233 http://eggnogapi.embl.de/nog_data/html/tree/COG0233 eggNOG ENOG4108VCV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108VCV epestfind swissprot:RRF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RRF_ECOLI garnier swissprot:RRF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RRF_ECOLI helixturnhelix swissprot:RRF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RRF_ECOLI hmoment swissprot:RRF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RRF_ECOLI iep swissprot:RRF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RRF_ECOLI inforesidue swissprot:RRF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RRF_ECOLI octanol swissprot:RRF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RRF_ECOLI pepcoil swissprot:RRF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RRF_ECOLI pepdigest swissprot:RRF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RRF_ECOLI pepinfo swissprot:RRF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RRF_ECOLI pepnet swissprot:RRF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RRF_ECOLI pepstats swissprot:RRF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RRF_ECOLI pepwheel swissprot:RRF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RRF_ECOLI pepwindow swissprot:RRF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RRF_ECOLI sigcleave swissprot:RRF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RRF_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES SPED_ECOLI Kinetic parameters KM=60 uM for S-adenosyl-L-methionine (at 25 degrees Celsius in the presence of 0.01 M MgCl(2)) {ECO 0000269|PubMed 6749853}; Vmax=3.8 umol/min/mg enzyme (at 25 degrees Celsius in the presence of 0.01M MgCl(2)) {ECO 0000269|PubMed 6749853}; Vmax=6.8 umol/min/mg enzyme (at 37 degrees Celsius in the presence of 0.1M MgCl(2)) {ECO 0000269|PubMed 6749853}; pH dependence Optimum pH is 7.4. Active from pH 6.7 to 8.5. {ECO 0000269|PubMed 17567041, ECO 0000269|PubMed 6749853}; # BioGrid 4262031 9 # CATALYTIC ACTIVITY S-adenosyl-L-methionine = S-adenosyl 3- (methylthio)propylamine + CO(2). {ECO:0000269|PubMed 6749853}. # COFACTOR SPED_ECOLI Name=pyruvate; Xref=ChEBI CHEBI 15361; Evidence={ECO 0000269|PubMed 3316212, ECO 0000269|PubMed 3546296, ECO 0000269|PubMed 6749853}; Note=Binds 1 pyruvoyl group covalently per subunit. {ECO 0000269|PubMed 3316212, ECO 0000269|PubMed 3546296, ECO 0000269|PubMed 6749853}; # ENZYME REGULATION SPED_ECOLI Allosterically activated by metal cations, which are absolutely required for activity. The presumed physiological activator is Mg(2+), but can also be activated in vitro by other divalent cations such as Mn(2+), Fe(2+) and Ca(2+), by the monovalent cation Li(+), and by trivalent cations such as Eu(3+), Tb(3+) and Gd(3+). Competitively inhibited by methylglyoxal bis-guanylhydrazone. Also inhibited by Zn(2+), inhibition may be due to interaction with the active site cysteine. Inactivated by treatment with the imine reductant NaCNBH(3) only in the presence of substrate. {ECO 0000269|PubMed 17567041, ECO 0000269|PubMed 3546296, ECO 0000269|PubMed 6749853}. # EcoGene EG10962 speD # FUNCTION SPED_ECOLI Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004014 adenosylmethionine decarboxylase activity; IDA:EcoCyc. # GO_process GO:0006557 S-adenosylmethioninamine biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0008295 spermidine biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.60.90.10 -; 1. # HAMAP MF_00465 AdoMetDC_2 # IntAct P0A7F6 4 # InterPro IPR003826 AdoMetDC_fam_prok # InterPro IPR009165 S-AdoMet_deCO2ase_bac # InterPro IPR016067 S-AdoMet_deCO2ase_core # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00270 Cysteine and methionine metabolism # KEGG_Pathway ko00330 Arginine and proline metabolism # MISCELLANEOUS SPED_ECOLI Spermidine-deficient mutants show a small decrease in growth rate and increased sensibility to superoxide toxicity. # Organism SPED_ECOLI Escherichia coli (strain K12) # PATHWAY Amine and polyamine biosynthesis; S- adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine step 1/1. # PATRIC 32115341 VBIEscCol129921_0122 # PIR B29778 DCECDM # PIRSF PIRSF001356 SAM_decarboxylas # PTM SPED_ECOLI Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N- terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain. {ECO 0000269|PubMed 3316212, ECO 0000269|PubMed 3546296}. # Pfam PF02675 AdoMet_dc # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SPED_ECOLI S-adenosylmethionine decarboxylase alpha chain # RecName SPED_ECOLI S-adenosylmethionine decarboxylase beta chain # RecName SPED_ECOLI S-adenosylmethionine decarboxylase beta chain # RecName SPED_ECOLI S-adenosylmethionine decarboxylase proenzyme # RefSeq NP_414662 NC_000913.3 # RefSeq WP_000734287 NZ_LN832404.1 # SIMILARITY Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily. {ECO 0000305}. # SUBUNIT Heterooctamer of four alpha and four beta chains arranged as a tetramer of alpha/beta heterodimers. {ECO:0000269|PubMed 3546296}. # SUPFAM SSF56276 SSF56276; 2 # TIGRFAMs TIGR03331 SAM_DCase_Eco # UniPathway UPA00331 UER00451 # eggNOG COG1586 LUCA # eggNOG ENOG4105FDS Bacteria BLAST swissprot:SPED_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SPED_ECOLI BioCyc ECOL316407:JW0116-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0116-MONOMER BioCyc EcoCyc:SPED-MONOMER http://biocyc.org/getid?id=EcoCyc:SPED-MONOMER BioCyc MetaCyc:SPED-MONOMER http://biocyc.org/getid?id=MetaCyc:SPED-MONOMER COG COG1586 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1586 DIP DIP-47936N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47936N DOI 10.1021/bi6025962 http://dx.doi.org/10.1021/bi6025962 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.87.7.2851 http://dx.doi.org/10.1073/pnas.87.7.2851 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.1.1.50 http://www.genome.jp/dbget-bin/www_bget?EC:4.1.1.50 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J02804 http://www.ebi.ac.uk/ena/data/view/J02804 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 4.1.1.50 http://enzyme.expasy.org/EC/4.1.1.50 EchoBASE EB0955 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0955 EcoGene EG10962 http://www.ecogene.org/geneInfo.php?eg_id=EG10962 EnsemblBacteria AAC73231 http://www.ensemblgenomes.org/id/AAC73231 EnsemblBacteria AAC73231 http://www.ensemblgenomes.org/id/AAC73231 EnsemblBacteria BAB96694 http://www.ensemblgenomes.org/id/BAB96694 EnsemblBacteria BAB96694 http://www.ensemblgenomes.org/id/BAB96694 EnsemblBacteria BAB96694 http://www.ensemblgenomes.org/id/BAB96694 EnsemblBacteria b0120 http://www.ensemblgenomes.org/id/b0120 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004014 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004014 GO_process GO:0006557 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006557 GO_process GO:0008295 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008295 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.60.90.10 http://www.cathdb.info/version/latest/superfamily/3.60.90.10 GeneID 947719 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947719 HAMAP MF_00465 http://hamap.expasy.org/unirule/MF_00465 HOGENOM HOG000116821 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000116821&db=HOGENOM6 InParanoid P0A7F6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7F6 IntAct P0A7F6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7F6* IntEnz 4.1.1.50 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.1.50 InterPro IPR003826 http://www.ebi.ac.uk/interpro/entry/IPR003826 InterPro IPR009165 http://www.ebi.ac.uk/interpro/entry/IPR009165 InterPro IPR016067 http://www.ebi.ac.uk/interpro/entry/IPR016067 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0116 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0116 KEGG_Gene eco:b0120 http://www.genome.jp/dbget-bin/www_bget?eco:b0120 KEGG_Orthology KO:K01611 http://www.genome.jp/dbget-bin/www_bget?KO:K01611 KEGG_Pathway ko00270 http://www.genome.jp/kegg-bin/show_pathway?ko00270 KEGG_Pathway ko00330 http://www.genome.jp/kegg-bin/show_pathway?ko00330 KEGG_Reaction rn:R00178 http://www.genome.jp/dbget-bin/www_bget?rn:R00178 OMA YNAERLT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YNAERLT PSORT swissprot:SPED_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SPED_ECOLI PSORT-B swissprot:SPED_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SPED_ECOLI PSORT2 swissprot:SPED_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SPED_ECOLI Pfam PF02675 http://pfam.xfam.org/family/PF02675 Phobius swissprot:SPED_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SPED_ECOLI ProteinModelPortal P0A7F6 http://www.proteinmodelportal.org/query/uniprot/P0A7F6 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17567041 http://www.ncbi.nlm.nih.gov/pubmed/17567041 PubMed 2181453 http://www.ncbi.nlm.nih.gov/pubmed/2181453 PubMed 3316212 http://www.ncbi.nlm.nih.gov/pubmed/3316212 PubMed 3546296 http://www.ncbi.nlm.nih.gov/pubmed/3546296 PubMed 6749853 http://www.ncbi.nlm.nih.gov/pubmed/6749853 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414662 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414662 RefSeq WP_000734287 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000734287 STRING 511145.b0120 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0120&targetmode=cogs STRING COG1586 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1586&targetmode=cogs SUPFAM SSF56276 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56276 TIGRFAMs TIGR03331 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03331 UniProtKB SPED_ECOLI http://www.uniprot.org/uniprot/SPED_ECOLI UniProtKB-AC P0A7F6 http://www.uniprot.org/uniprot/P0A7F6 charge swissprot:SPED_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SPED_ECOLI eggNOG COG1586 http://eggnogapi.embl.de/nog_data/html/tree/COG1586 eggNOG ENOG4105FDS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FDS epestfind swissprot:SPED_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SPED_ECOLI garnier swissprot:SPED_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SPED_ECOLI helixturnhelix swissprot:SPED_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SPED_ECOLI hmoment swissprot:SPED_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SPED_ECOLI iep swissprot:SPED_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SPED_ECOLI inforesidue swissprot:SPED_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SPED_ECOLI octanol swissprot:SPED_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SPED_ECOLI pepcoil swissprot:SPED_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SPED_ECOLI pepdigest swissprot:SPED_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SPED_ECOLI pepinfo swissprot:SPED_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SPED_ECOLI pepnet swissprot:SPED_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SPED_ECOLI pepstats swissprot:SPED_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SPED_ECOLI pepwheel swissprot:SPED_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SPED_ECOLI pepwindow swissprot:SPED_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SPED_ECOLI sigcleave swissprot:SPED_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SPED_ECOLI ## Database ID URL or Descriptions # BioGrid 4263008 10 # EcoGene EG12863 yecH # IntAct P46887 2 # InterPro IPR019620 Metal-bd_prot_put # Organism YECH_ECOLI Escherichia coli (strain K12) # PATRIC 32119141 VBIEscCol129921_1988 # PIR B64954 B64954 # Pfam PF10678 DUF2492 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YECH_ECOLI Uncharacterized protein YecH # RefSeq NP_416419 NC_000913.3 # RefSeq WP_000377225 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA79048.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # TIGRFAMs TIGR03853 matur_matur # eggNOG ENOG4105VVZ Bacteria # eggNOG ENOG41122EF LUCA BLAST swissprot:YECH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YECH_ECOLI BioCyc ECOL316407:JW1894-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1894-MONOMER BioCyc EcoCyc:G7036-MONOMER http://biocyc.org/getid?id=EcoCyc:G7036-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U35066 http://www.ebi.ac.uk/ena/data/view/U35066 EchoBASE EB2705 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2705 EcoGene EG12863 http://www.ecogene.org/geneInfo.php?eg_id=EG12863 EnsemblBacteria AAC74976 http://www.ensemblgenomes.org/id/AAC74976 EnsemblBacteria AAC74976 http://www.ensemblgenomes.org/id/AAC74976 EnsemblBacteria BAA15729 http://www.ensemblgenomes.org/id/BAA15729 EnsemblBacteria BAA15729 http://www.ensemblgenomes.org/id/BAA15729 EnsemblBacteria BAA15729 http://www.ensemblgenomes.org/id/BAA15729 EnsemblBacteria b1906 http://www.ensemblgenomes.org/id/b1906 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946411 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946411 HOGENOM HOG000222013 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000222013&db=HOGENOM6 InParanoid P46887 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P46887 IntAct P46887 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P46887* InterPro IPR019620 http://www.ebi.ac.uk/interpro/entry/IPR019620 KEGG_Gene ecj:JW1894 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1894 KEGG_Gene eco:b1906 http://www.genome.jp/dbget-bin/www_bget?eco:b1906 OMA CSAENMT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CSAENMT PSORT swissprot:YECH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YECH_ECOLI PSORT-B swissprot:YECH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YECH_ECOLI PSORT2 swissprot:YECH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YECH_ECOLI Pfam PF10678 http://pfam.xfam.org/family/PF10678 Phobius swissprot:YECH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YECH_ECOLI ProteinModelPortal P46887 http://www.proteinmodelportal.org/query/uniprot/P46887 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416419 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416419 RefSeq WP_000377225 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000377225 STRING 511145.b1906 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1906&targetmode=cogs TIGRFAMs TIGR03853 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03853 UniProtKB YECH_ECOLI http://www.uniprot.org/uniprot/YECH_ECOLI UniProtKB-AC P46887 http://www.uniprot.org/uniprot/P46887 charge swissprot:YECH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YECH_ECOLI eggNOG ENOG4105VVZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VVZ eggNOG ENOG41122EF http://eggnogapi.embl.de/nog_data/html/tree/ENOG41122EF epestfind swissprot:YECH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YECH_ECOLI garnier swissprot:YECH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YECH_ECOLI helixturnhelix swissprot:YECH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YECH_ECOLI hmoment swissprot:YECH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YECH_ECOLI iep swissprot:YECH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YECH_ECOLI inforesidue swissprot:YECH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YECH_ECOLI octanol swissprot:YECH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YECH_ECOLI pepcoil swissprot:YECH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YECH_ECOLI pepdigest swissprot:YECH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YECH_ECOLI pepinfo swissprot:YECH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YECH_ECOLI pepnet swissprot:YECH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YECH_ECOLI pepstats swissprot:YECH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YECH_ECOLI pepwheel swissprot:YECH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YECH_ECOLI pepwindow swissprot:YECH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YECH_ECOLI sigcleave swissprot:YECH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YECH_ECOLI ## Database ID URL or Descriptions # BioGrid 4259161 12 # CATALYTIC ACTIVITY YEDV_ECOLI ATP + protein L-histidine = ADP + protein N- phospho-L-histidine. # CDD cd06225 HAMP # EcoGene EG14044 yedV # FUNCTION YEDV_ECOLI Probable member of a two-component regulatory system YedW/YedV. Activates YedW by phosphorylation. {ECO 0000269|PubMed 15522865}. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0000155 phosphorelay sensor kinase activity; IEA:InterPro. # GO_function GO:0004672 protein kinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005622 intracellular # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # Gene3D 1.10.287.130 -; 1. # Gene3D 3.30.565.10 -; 1. # INTERACTION YEDV_ECOLI Q46896 ygbT; NbExp=3; IntAct=EBI-554869, EBI-1130209; # IntAct P76339 4 # InterPro IPR003594 HATPase_C # InterPro IPR003660 HAMP_dom # InterPro IPR003661 HisK_dim/P # InterPro IPR004358 Sig_transdc_His_kin-like_C # InterPro IPR005467 His_kinase_dom # InterPro IPR006290 CztS_silS_copS # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01001 Protein kinases # KEGG_Brite ko02022 Two-component system # Organism YEDV_ECOLI Escherichia coli (strain K12) # PATRIC 32119267 VBIEscCol129921_2048 # PIR D64961 D64961 # PRINTS PR00344 BCTRLSENSOR # PROSITE PS50109 HIS_KIN # PROSITE PS50885 HAMP # PTM YEDV_ECOLI Autophosphorylated. # Pfam PF00512 HisKA # Pfam PF00672 HAMP # Pfam PF02518 HATPase_c # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEDV_ECOLI Probable sensor-like histidine kinase YedV # RefSeq NP_416477 NC_000913.3 # RefSeq WP_000826792 NZ_LN832404.1 # SIMILARITY Contains 1 HAMP domain. {ECO:0000255|PROSITE- ProRule PRU00102}. # SIMILARITY Contains 1 histidine kinase domain. {ECO:0000255|PROSITE-ProRule PRU00107}. # SMART SM00387 HATPase_c # SMART SM00388 HisKA # SUBCELLULAR LOCATION YEDV_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF47384 SSF47384 # SUPFAM SSF55874 SSF55874 # TIGRFAMs TIGR01386 cztS_silS_copS # eggNOG COG0642 LUCA # eggNOG ENOG4107ZY3 Bacteria BLAST swissprot:YEDV_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEDV_ECOLI BioCyc ECOL316407:JW1951-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1951-MONOMER BioCyc EcoCyc:G7056-MONOMER http://biocyc.org/getid?id=EcoCyc:G7056-MONOMER COG COG0642 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0642 DIP DIP-11852N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11852N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M410104200 http://dx.doi.org/10.1074/jbc.M410104200 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.13.3 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.13.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.13.3 http://enzyme.expasy.org/EC/2.7.13.3 EchoBASE EB3797 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3797 EcoGene EG14044 http://www.ecogene.org/geneInfo.php?eg_id=EG14044 EnsemblBacteria AAC75034 http://www.ensemblgenomes.org/id/AAC75034 EnsemblBacteria AAC75034 http://www.ensemblgenomes.org/id/AAC75034 EnsemblBacteria BAA15795 http://www.ensemblgenomes.org/id/BAA15795 EnsemblBacteria BAA15795 http://www.ensemblgenomes.org/id/BAA15795 EnsemblBacteria BAA15795 http://www.ensemblgenomes.org/id/BAA15795 EnsemblBacteria b1968 http://www.ensemblgenomes.org/id/b1968 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0000155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000155 GO_function GO:0004672 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004672 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 1.10.287.130 http://www.cathdb.info/version/latest/superfamily/1.10.287.130 Gene3D 3.30.565.10 http://www.cathdb.info/version/latest/superfamily/3.30.565.10 GeneID 946487 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946487 HOGENOM HOG000126762 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126762&db=HOGENOM6 InParanoid P76339 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76339 IntAct P76339 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76339* IntEnz 2.7.13.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.13.3 InterPro IPR003594 http://www.ebi.ac.uk/interpro/entry/IPR003594 InterPro IPR003660 http://www.ebi.ac.uk/interpro/entry/IPR003660 InterPro IPR003661 http://www.ebi.ac.uk/interpro/entry/IPR003661 InterPro IPR004358 http://www.ebi.ac.uk/interpro/entry/IPR004358 InterPro IPR005467 http://www.ebi.ac.uk/interpro/entry/IPR005467 InterPro IPR006290 http://www.ebi.ac.uk/interpro/entry/IPR006290 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01001 http://www.genome.jp/dbget-bin/www_bget?ko01001 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW1951 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1951 KEGG_Gene eco:b1968 http://www.genome.jp/dbget-bin/www_bget?eco:b1968 KEGG_Orthology KO:K02484 http://www.genome.jp/dbget-bin/www_bget?KO:K02484 MINT MINT-1232374 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1232374 OMA KSHIHIT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KSHIHIT PRINTS PR00344 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00344 PROSITE PS50109 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50109 PROSITE PS50885 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50885 PSORT swissprot:YEDV_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEDV_ECOLI PSORT-B swissprot:YEDV_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEDV_ECOLI PSORT2 swissprot:YEDV_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEDV_ECOLI Pfam PF00512 http://pfam.xfam.org/family/PF00512 Pfam PF00672 http://pfam.xfam.org/family/PF00672 Pfam PF02518 http://pfam.xfam.org/family/PF02518 Phobius swissprot:YEDV_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEDV_ECOLI PhylomeDB P76339 http://phylomedb.org/?seqid=P76339 ProteinModelPortal P76339 http://www.proteinmodelportal.org/query/uniprot/P76339 PubMed 15522865 http://www.ncbi.nlm.nih.gov/pubmed/15522865 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416477 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416477 RefSeq WP_000826792 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000826792 SMART SM00387 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00387 SMART SM00388 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00388 SMR P76339 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76339 STRING 511145.b1968 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1968&targetmode=cogs STRING COG0642 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0642&targetmode=cogs SUPFAM SSF47384 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47384 SUPFAM SSF55874 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55874 TIGRFAMs TIGR01386 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01386 UniProtKB YEDV_ECOLI http://www.uniprot.org/uniprot/YEDV_ECOLI UniProtKB-AC P76339 http://www.uniprot.org/uniprot/P76339 charge swissprot:YEDV_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEDV_ECOLI eggNOG COG0642 http://eggnogapi.embl.de/nog_data/html/tree/COG0642 eggNOG ENOG4107ZY3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107ZY3 epestfind swissprot:YEDV_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEDV_ECOLI garnier swissprot:YEDV_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEDV_ECOLI helixturnhelix swissprot:YEDV_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEDV_ECOLI hmoment swissprot:YEDV_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEDV_ECOLI iep swissprot:YEDV_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEDV_ECOLI inforesidue swissprot:YEDV_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEDV_ECOLI octanol swissprot:YEDV_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEDV_ECOLI pepcoil swissprot:YEDV_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEDV_ECOLI pepdigest swissprot:YEDV_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEDV_ECOLI pepinfo swissprot:YEDV_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEDV_ECOLI pepnet swissprot:YEDV_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEDV_ECOLI pepstats swissprot:YEDV_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEDV_ECOLI pepwheel swissprot:YEDV_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEDV_ECOLI pepwindow swissprot:YEDV_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEDV_ECOLI sigcleave swissprot:YEDV_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEDV_ECOLI ## Database ID URL or Descriptions # AltName INSA6_ECOLI IS1e # EcoGene EG40001 insA6 # FUNCTION INSA6_ECOLI Absolutely required for transposition of IS1. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 1.10.10.60 -; 1. # InterPro IPR003220 InsA_N_dom # InterPro IPR009057 Homeodomain-like # InterPro IPR024431 InsA_HTH_dom # Organism INSA6_ECOLI Escherichia coli (strain K12) # Pfam PF03811 Zn_Tnp_IS1 # Pfam PF12759 HTH_Tnp_IS1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSA6_ECOLI Insertion element IS1 6 protein InsA # RefSeq NP_414563 NC_000913.3 # RefSeq NP_416408 NC_000913.3 # RefSeq NP_417901 NC_000913.3 # RefSeq WP_000179213 NZ_LN832404.1 # RefSeq YP_001816554 NC_010558.1 # RefSeq YP_001816567 NC_010558.1 # RefSeq YP_002527490 NC_011964.1 # RefSeq YP_003937745 NC_014615.1 # RefSeq YP_004422909 NC_015472.1 # RefSeq YP_444026 NC_007675.1 # RefSeq YP_444042 NC_007675.1 # SIMILARITY Belongs to the IS1 elements InsA family. {ECO 0000305}. # eggNOG COG3677 LUCA BLAST swissprot:INSA6_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSA6_ECOLI BioCyc EcoCyc:MONOMER0-4226 http://biocyc.org/getid?id=EcoCyc:MONOMER0-4226 DOI 10.1016/0378-1119(91)90096-T http://dx.doi.org/10.1016/0378-1119(91)90096-T DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X52537 http://www.ebi.ac.uk/ena/data/view/X52537 EchoBASE EB4729 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4729 EcoGene EG40001 http://www.ecogene.org/geneInfo.php?eg_id=EG40001 EnsemblBacteria AAC76469 http://www.ensemblgenomes.org/id/AAC76469 EnsemblBacteria AAC76469 http://www.ensemblgenomes.org/id/AAC76469 EnsemblBacteria BAE77849 http://www.ensemblgenomes.org/id/BAE77849 EnsemblBacteria BAE77849 http://www.ensemblgenomes.org/id/BAE77849 EnsemblBacteria BAE77849 http://www.ensemblgenomes.org/id/BAE77849 EnsemblBacteria b3444 http://www.ensemblgenomes.org/id/b3444 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 GeneID 10549031 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10549031 GeneID 24901758 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24901758 GeneID 3853367 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3853367 GeneID 3853482 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3853482 GeneID 6276006 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6276006 GeneID 6276014 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6276014 GeneID 7324512 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7324512 GeneID 945800 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945800 GeneID 947950 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947950 GeneID 948449 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948449 GeneID 9846072 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9846072 InParanoid P0CF12 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CF12 InterPro IPR003220 http://www.ebi.ac.uk/interpro/entry/IPR003220 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR024431 http://www.ebi.ac.uk/interpro/entry/IPR024431 KEGG_Gene ecj:JW3408 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3408 KEGG_Gene eco:b0022 http://www.genome.jp/dbget-bin/www_bget?eco:b0022 KEGG_Gene eco:b1894 http://www.genome.jp/dbget-bin/www_bget?eco:b1894 KEGG_Gene eco:b3444 http://www.genome.jp/dbget-bin/www_bget?eco:b3444 PSORT swissprot:INSA6_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSA6_ECOLI PSORT-B swissprot:INSA6_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSA6_ECOLI PSORT2 swissprot:INSA6_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSA6_ECOLI Pfam PF03811 http://pfam.xfam.org/family/PF03811 Pfam PF12759 http://pfam.xfam.org/family/PF12759 Phobius swissprot:INSA6_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSA6_ECOLI PhylomeDB P0CF12 http://phylomedb.org/?seqid=P0CF12 ProteinModelPortal P0CF12 http://www.proteinmodelportal.org/query/uniprot/P0CF12 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1849492 http://www.ncbi.nlm.nih.gov/pubmed/1849492 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414563 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414563 RefSeq NP_416408 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416408 RefSeq NP_417901 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417901 RefSeq WP_000179213 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000179213 RefSeq YP_001816554 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001816554 RefSeq YP_001816567 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001816567 RefSeq YP_002527490 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_002527490 RefSeq YP_003937745 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_003937745 RefSeq YP_004422909 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_004422909 RefSeq YP_444026 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_444026 RefSeq YP_444042 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_444042 STRING 511145.b3444 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3444&targetmode=cogs UniProtKB INSA6_ECOLI http://www.uniprot.org/uniprot/INSA6_ECOLI UniProtKB-AC P0CF12 http://www.uniprot.org/uniprot/P0CF12 charge swissprot:INSA6_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSA6_ECOLI eggNOG COG3677 http://eggnogapi.embl.de/nog_data/html/tree/COG3677 epestfind swissprot:INSA6_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSA6_ECOLI garnier swissprot:INSA6_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSA6_ECOLI helixturnhelix swissprot:INSA6_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSA6_ECOLI hmoment swissprot:INSA6_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSA6_ECOLI iep swissprot:INSA6_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSA6_ECOLI inforesidue swissprot:INSA6_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSA6_ECOLI octanol swissprot:INSA6_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSA6_ECOLI pepcoil swissprot:INSA6_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSA6_ECOLI pepdigest swissprot:INSA6_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSA6_ECOLI pepinfo swissprot:INSA6_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSA6_ECOLI pepnet swissprot:INSA6_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSA6_ECOLI pepstats swissprot:INSA6_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSA6_ECOLI pepwheel swissprot:INSA6_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSA6_ECOLI pepwindow swissprot:INSA6_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSA6_ECOLI sigcleave swissprot:INSA6_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSA6_ECOLI ## Database ID URL or Descriptions # AltName ATP-dependent helicase PriA {ECO:0000255|HAMAP-Rule MF_00983} # AltName PRIA_ECOLI Replication factor Y # BioGrid 4262651 62 # DISRUPTION PHENOTYPE Mutants show delayed replication restart after exposition to UV. {ECO:0000269|PubMed 11929519}. # DOMAIN PRIA_ECOLI Contains an N-terminal DNA-binding domain and a C-terminal helicase domain. The helicase domain plays an important role in high affinity and stable binding of PriA to forked DNAs. {ECO 0000269|PubMed 12622722, ECO 0000269|PubMed 17483094}. # ENZYME REGULATION PRIA_ECOLI ATPase activity is stimulated by binding to DNA. Helicase activity is stimulated by SSB. {ECO 0000269|PubMed 12622722, ECO 0000269|PubMed 15576682, ECO 0000269|PubMed 17483094}. # EcoGene EG10763 priA # FUNCTION PRIA_ECOLI Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA. Is also involved in initiation of normal DNA replication in various plasmids and phages. Binds to branched DNA structures that resemble D-loops or to the primosome assembly site (PAS). Binds to DNA in two distinct modes, either dependent on or independent of the 3' terminus recognition. {ECO 0000255|HAMAP-Rule MF_00983, ECO 0000269|PubMed 10356325, ECO 0000269|PubMed 10956036, ECO 0000269|PubMed 11929519, ECO 0000269|PubMed 12622722, ECO 0000269|PubMed 12917421, ECO 0000269|PubMed 15576682, ECO 0000269|PubMed 17483094, ECO 0000269|PubMed 23264623, ECO 0000269|PubMed 2825188, ECO 0000269|PubMed 8366072}. # GO_component GO:1990077 primosome complex; IEA:UniProtKB-HAMAP. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0004386 helicase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008270 zinc ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0043140 ATP-dependent 3'-5' DNA helicase activity; IDA:EcoCyc. # GO_process GO:0006260 DNA replication; IMP:EcoCyc. # GO_process GO:0006261 DNA-dependent DNA replication; IDA:EcoliWiki. # GO_process GO:0006268 DNA unwinding involved in DNA replication; IDA:EcoCyc. # GO_process GO:0006269 DNA replication, synthesis of RNA primer; IEA:UniProtKB-KW. # GO_process GO:0006270 DNA replication initiation; IMP:EcoCyc. # GO_process GO:0006276 plasmid maintenance; IMP:EcoCyc. # GO_process GO:0006302 double-strand break repair; IMP:EcoliWiki. # GO_process GO:0006310 DNA recombination; IMP:EcoliWiki. # GO_process GO:0010332 response to gamma radiation; IMP:EcoliWiki. # GO_process GO:0046677 response to antibiotic; IMP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004386 helicase activity # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0051276 chromosome organization # Gene3D 3.40.50.300 -; 2. # HAMAP MF_00983 PriA # INDUCTION Induced by hydroxyurea. {ECO:0000269|PubMed 20005847}. # INTERACTION PRIA_ECOLI P07013 priB; NbExp=3; IntAct=EBI-552050, EBI-1125223; P0AGE0 ssb; NbExp=2; IntAct=EBI-552050, EBI-1118620; # IntAct P17888 16 # InterPro IPR001650 Helicase_C # InterPro IPR005259 PriA # InterPro IPR011545 DEAD/DEAH_box_helicase_dom # InterPro IPR014001 Helicase_ATP-bd # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko03440 Homologous recombination # Organism PRIA_ECOLI Escherichia coli (strain K12) # PATRIC 32123387 VBIEscCol129921_4054 # PDB 2D7E X-ray; 2.50 A; A/B/C/D=1-105 # PDB 2D7G X-ray; 3.30 A; A/B/C/D=1-105 # PDB 2D7H X-ray; 3.00 A; A/B/C/D=1-105 # PDB 2DWL X-ray; 3.20 A; A/B/C/D=1-105 # PDB 2DWM X-ray; 3.15 A; A/B/C/D=1-105 # PDB 2DWN X-ray; 3.35 A; A/B/C/D=1-105 # PIR S40878 A35505 # PROSITE PS51192 HELICASE_ATP_BIND_1 # PROSITE PS51194 HELICASE_CTER # Pfam PF00270 DEAD # Pfam PF00271 Helicase_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Primosomal protein N' {ECO:0000255|HAMAP-Rule MF_00983} # RefSeq NP_418370 NC_000913.3 # RefSeq WP_001301269 NZ_LN832404.1 # SIMILARITY Belongs to the helicase family. PriA subfamily. {ECO:0000255|HAMAP-Rule MF_00983}. # SIMILARITY Contains 1 helicase ATP-binding domain. {ECO:0000255|HAMAP-Rule MF_00983}. # SIMILARITY Contains 1 helicase C-terminal domain. {ECO:0000255|HAMAP-Rule MF_00983}. # SMART SM00487 DEXDc # SMART SM00490 HELICc # SUBUNIT PRIA_ECOLI Component of the primosome, which is composed of PriA, PriB, PriC, DnaB, DnaC, DnaG and DnaT. Binds ssDNA as a monomer. Interacts with SSB and PriB. {ECO 0000255|HAMAP-Rule MF_00983, ECO 0000269|PubMed 10956036, ECO 0000269|PubMed 15576682, ECO 0000269|PubMed 17588514, ECO 0000269|PubMed 8366072}. # SUPFAM SSF52540 SSF52540; 2 # TIGRFAMs TIGR00595 priA # eggNOG COG1198 LUCA # eggNOG ENOG4105C25 Bacteria BLAST swissprot:PRIA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PRIA_ECOLI BioCyc ECOL316407:JW3906-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3906-MONOMER BioCyc EcoCyc:EG10763-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10763-MONOMER BioCyc MetaCyc:EG10763-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10763-MONOMER COG COG1198 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1198 DIP DIP-10562N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10562N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/jmbi.1999.2783 http://dx.doi.org/10.1006/jmbi.1999.2783 DOI 10.1016/j.molcel.2007.05.012 http://dx.doi.org/10.1016/j.molcel.2007.05.012 DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1021/bi001113y http://dx.doi.org/10.1021/bi001113y DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2443.2003.00630.x http://dx.doi.org/10.1046/j.1365-2443.2003.00630.x DOI 10.1046/j.1365-2958.2002.02747.x http://dx.doi.org/10.1046/j.1365-2958.2002.02747.x DOI 10.1073/pnas.84.23.8345 http://dx.doi.org/10.1073/pnas.84.23.8345 DOI 10.1073/pnas.87.12.4615 http://dx.doi.org/10.1073/pnas.87.12.4615 DOI 10.1073/pnas.87.12.4620 http://dx.doi.org/10.1073/pnas.87.12.4620 DOI 10.1074/jbc.C300285200 http://dx.doi.org/10.1074/jbc.C300285200 DOI 10.1074/jbc.M112.435966 http://dx.doi.org/10.1074/jbc.M112.435966 DOI 10.1074/jbc.M701848200 http://dx.doi.org/10.1074/jbc.M701848200 DOI 10.1093/nar/19.24.6953 http://dx.doi.org/10.1093/nar/19.24.6953 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1093/nar/gkh980 http://dx.doi.org/10.1093/nar/gkh980 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.4.- {ECO:0000255|HAMAP-Rule:MF_00983} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.4.- {ECO:0000255|HAMAP-Rule:MF_00983} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D00616 http://www.ebi.ac.uk/ena/data/view/D00616 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL M33293 http://www.ebi.ac.uk/ena/data/view/M33293 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.6.4.- {ECO:0000255|HAMAP-Rule:MF_00983} http://enzyme.expasy.org/EC/3.6.4.- {ECO:0000255|HAMAP-Rule:MF_00983} EchoBASE EB0756 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0756 EcoGene EG10763 http://www.ecogene.org/geneInfo.php?eg_id=EG10763 EnsemblBacteria AAC76917 http://www.ensemblgenomes.org/id/AAC76917 EnsemblBacteria AAC76917 http://www.ensemblgenomes.org/id/AAC76917 EnsemblBacteria BAE77375 http://www.ensemblgenomes.org/id/BAE77375 EnsemblBacteria BAE77375 http://www.ensemblgenomes.org/id/BAE77375 EnsemblBacteria BAE77375 http://www.ensemblgenomes.org/id/BAE77375 EnsemblBacteria b3935 http://www.ensemblgenomes.org/id/b3935 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:1990077 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990077 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004386 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0043140 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043140 GO_process GO:0006260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260 GO_process GO:0006261 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006261 GO_process GO:0006268 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006268 GO_process GO:0006269 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006269 GO_process GO:0006270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006270 GO_process GO:0006276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006276 GO_process GO:0006302 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006302 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0010332 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010332 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004386 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0051276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051276 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948426 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948426 HAMAP MF_00983 http://hamap.expasy.org/unirule/MF_00983 HOGENOM HOG000037413 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000037413&db=HOGENOM6 InParanoid P17888 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P17888 IntAct P17888 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P17888* IntEnz 3.6.4.- {ECO:0000255|HAMAP-Rule:MF_00983} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.4.- {ECO:0000255|HAMAP-Rule:MF_00983} InterPro IPR001650 http://www.ebi.ac.uk/interpro/entry/IPR001650 InterPro IPR005259 http://www.ebi.ac.uk/interpro/entry/IPR005259 InterPro IPR011545 http://www.ebi.ac.uk/interpro/entry/IPR011545 InterPro IPR014001 http://www.ebi.ac.uk/interpro/entry/IPR014001 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW3906 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3906 KEGG_Gene eco:b3935 http://www.genome.jp/dbget-bin/www_bget?eco:b3935 KEGG_Orthology KO:K04066 http://www.genome.jp/dbget-bin/www_bget?KO:K04066 KEGG_Pathway ko03440 http://www.genome.jp/kegg-bin/show_pathway?ko03440 MINT MINT-1274231 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1274231 OMA QRFNAPV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QRFNAPV PDB 2D7E http://www.ebi.ac.uk/pdbe-srv/view/entry/2D7E PDB 2D7G http://www.ebi.ac.uk/pdbe-srv/view/entry/2D7G PDB 2D7H http://www.ebi.ac.uk/pdbe-srv/view/entry/2D7H PDB 2DWL http://www.ebi.ac.uk/pdbe-srv/view/entry/2DWL PDB 2DWM http://www.ebi.ac.uk/pdbe-srv/view/entry/2DWM PDB 2DWN http://www.ebi.ac.uk/pdbe-srv/view/entry/2DWN PDBsum 2D7E http://www.ebi.ac.uk/pdbsum/2D7E PDBsum 2D7G http://www.ebi.ac.uk/pdbsum/2D7G PDBsum 2D7H http://www.ebi.ac.uk/pdbsum/2D7H PDBsum 2DWL http://www.ebi.ac.uk/pdbsum/2DWL PDBsum 2DWM http://www.ebi.ac.uk/pdbsum/2DWM PDBsum 2DWN http://www.ebi.ac.uk/pdbsum/2DWN PROSITE PS51192 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51192 PROSITE PS51194 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51194 PSORT swissprot:PRIA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PRIA_ECOLI PSORT-B swissprot:PRIA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PRIA_ECOLI PSORT2 swissprot:PRIA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PRIA_ECOLI Pfam PF00270 http://pfam.xfam.org/family/PF00270 Pfam PF00271 http://pfam.xfam.org/family/PF00271 Phobius swissprot:PRIA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PRIA_ECOLI PhylomeDB P17888 http://phylomedb.org/?seqid=P17888 ProteinModelPortal P17888 http://www.proteinmodelportal.org/query/uniprot/P17888 PubMed 10356325 http://www.ncbi.nlm.nih.gov/pubmed/10356325 PubMed 10956036 http://www.ncbi.nlm.nih.gov/pubmed/10956036 PubMed 11929519 http://www.ncbi.nlm.nih.gov/pubmed/11929519 PubMed 12622722 http://www.ncbi.nlm.nih.gov/pubmed/12622722 PubMed 12917421 http://www.ncbi.nlm.nih.gov/pubmed/12917421 PubMed 15576682 http://www.ncbi.nlm.nih.gov/pubmed/15576682 PubMed 1662369 http://www.ncbi.nlm.nih.gov/pubmed/1662369 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17483094 http://www.ncbi.nlm.nih.gov/pubmed/17483094 PubMed 17588514 http://www.ncbi.nlm.nih.gov/pubmed/17588514 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 2162049 http://www.ncbi.nlm.nih.gov/pubmed/2162049 PubMed 2162050 http://www.ncbi.nlm.nih.gov/pubmed/2162050 PubMed 23264623 http://www.ncbi.nlm.nih.gov/pubmed/23264623 PubMed 2825188 http://www.ncbi.nlm.nih.gov/pubmed/2825188 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 8366072 http://www.ncbi.nlm.nih.gov/pubmed/8366072 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_418370 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418370 RefSeq WP_001301269 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001301269 SMART SM00487 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00487 SMART SM00490 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00490 SMR P17888 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P17888 STRING 511145.b3935 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3935&targetmode=cogs STRING COG1198 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1198&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR00595 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00595 UniProtKB PRIA_ECOLI http://www.uniprot.org/uniprot/PRIA_ECOLI UniProtKB-AC P17888 http://www.uniprot.org/uniprot/P17888 charge swissprot:PRIA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PRIA_ECOLI eggNOG COG1198 http://eggnogapi.embl.de/nog_data/html/tree/COG1198 eggNOG ENOG4105C25 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C25 epestfind swissprot:PRIA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PRIA_ECOLI garnier swissprot:PRIA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PRIA_ECOLI helixturnhelix swissprot:PRIA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PRIA_ECOLI hmoment swissprot:PRIA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PRIA_ECOLI iep swissprot:PRIA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PRIA_ECOLI inforesidue swissprot:PRIA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PRIA_ECOLI octanol swissprot:PRIA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PRIA_ECOLI pepcoil swissprot:PRIA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PRIA_ECOLI pepdigest swissprot:PRIA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PRIA_ECOLI pepinfo swissprot:PRIA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PRIA_ECOLI pepnet swissprot:PRIA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PRIA_ECOLI pepstats swissprot:PRIA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PRIA_ECOLI pepwheel swissprot:PRIA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PRIA_ECOLI pepwindow swissprot:PRIA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PRIA_ECOLI sigcleave swissprot:PRIA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PRIA_ECOLI ## Database ID URL or Descriptions # EcoGene EG14170 eutK # FUNCTION EUTK_ECOLI May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place. # GO_component GO:0031471 ethanolamine degradation polyhedral organelle; ISS:EcoCyc. # GO_function GO:0003677 DNA binding; IBA:GO_Central. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0005198 structural molecule activity; ISS:EcoCyc. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IBA:GO_Central. # GO_process GO:0046336 ethanolamine catabolic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0043226 organelle # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0005198 structural molecule activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.10.10 -; 1. # IntAct P76540 8 # InterPro IPR000249 Microcompartment_bac # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR020808 Bact_microcomp_CS # InterPro IPR032298 EutK_C # Organism EUTK_ECOLI Escherichia coli (strain K12) # PATHWAY EUTK_ECOLI Amine and polyamine degradation; ethanolamine degradation. # PATRIC 32120261 VBIEscCol129921_2533 # PDB 3I71 X-ray; 2.10 A; A/B=108-166 # PIR E65018 E65018 # PROSITE PS01139 BACT_MICROCOMP # Pfam PF00936 BMC # Pfam PF16365 EutK_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EUTK_ECOLI Ethanolamine utilization protein EutK # RefSeq NP_416933 NC_000913.3 # RefSeq WP_000606257 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial microcompartments protein family. {ECO 0000305}. # SMART SM00877 BMC # eggNOG COG4577 LUCA # eggNOG ENOG4108X49 Bacteria BLAST swissprot:EUTK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EUTK_ECOLI BioCyc ECOL316407:JW2431-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2431-MONOMER BioCyc EcoCyc:G7270-MONOMER http://biocyc.org/getid?id=EcoCyc:G7270-MONOMER COG COG4577 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4577 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3922 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3922 EcoGene EG14170 http://www.ecogene.org/geneInfo.php?eg_id=EG14170 EnsemblBacteria AAC75491 http://www.ensemblgenomes.org/id/AAC75491 EnsemblBacteria AAC75491 http://www.ensemblgenomes.org/id/AAC75491 EnsemblBacteria BAA16321 http://www.ensemblgenomes.org/id/BAA16321 EnsemblBacteria BAA16321 http://www.ensemblgenomes.org/id/BAA16321 EnsemblBacteria BAA16321 http://www.ensemblgenomes.org/id/BAA16321 EnsemblBacteria b2438 http://www.ensemblgenomes.org/id/b2438 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0031471 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031471 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0005198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005198 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GO_process GO:0046336 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046336 GOslim_component GO:0043226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0005198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005198 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 946912 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946912 HOGENOM HOG000123008 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000123008&db=HOGENOM6 IntAct P76540 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76540* InterPro IPR000249 http://www.ebi.ac.uk/interpro/entry/IPR000249 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR020808 http://www.ebi.ac.uk/interpro/entry/IPR020808 InterPro IPR032298 http://www.ebi.ac.uk/interpro/entry/IPR032298 KEGG_Gene ecj:JW2431 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2431 KEGG_Gene eco:b2438 http://www.genome.jp/dbget-bin/www_bget?eco:b2438 KEGG_Orthology KO:K04025 http://www.genome.jp/dbget-bin/www_bget?KO:K04025 OMA WLIGGFK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WLIGGFK PDB 3I71 http://www.ebi.ac.uk/pdbe-srv/view/entry/3I71 PDBsum 3I71 http://www.ebi.ac.uk/pdbsum/3I71 PROSITE PS01139 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01139 PSORT swissprot:EUTK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EUTK_ECOLI PSORT-B swissprot:EUTK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EUTK_ECOLI PSORT2 swissprot:EUTK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EUTK_ECOLI Pfam PF00936 http://pfam.xfam.org/family/PF00936 Pfam PF16365 http://pfam.xfam.org/family/PF16365 Phobius swissprot:EUTK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EUTK_ECOLI ProteinModelPortal P76540 http://www.proteinmodelportal.org/query/uniprot/P76540 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416933 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416933 RefSeq WP_000606257 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000606257 SMART SM00877 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00877 SMR P76540 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76540 STRING 511145.b2438 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2438&targetmode=cogs STRING COG4577 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4577&targetmode=cogs UniProtKB EUTK_ECOLI http://www.uniprot.org/uniprot/EUTK_ECOLI UniProtKB-AC P76540 http://www.uniprot.org/uniprot/P76540 charge swissprot:EUTK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EUTK_ECOLI eggNOG COG4577 http://eggnogapi.embl.de/nog_data/html/tree/COG4577 eggNOG ENOG4108X49 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108X49 epestfind swissprot:EUTK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EUTK_ECOLI garnier swissprot:EUTK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EUTK_ECOLI helixturnhelix swissprot:EUTK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EUTK_ECOLI hmoment swissprot:EUTK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EUTK_ECOLI iep swissprot:EUTK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EUTK_ECOLI inforesidue swissprot:EUTK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EUTK_ECOLI octanol swissprot:EUTK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EUTK_ECOLI pepcoil swissprot:EUTK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EUTK_ECOLI pepdigest swissprot:EUTK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EUTK_ECOLI pepinfo swissprot:EUTK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EUTK_ECOLI pepnet swissprot:EUTK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EUTK_ECOLI pepstats swissprot:EUTK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EUTK_ECOLI pepwheel swissprot:EUTK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EUTK_ECOLI pepwindow swissprot:EUTK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EUTK_ECOLI sigcleave swissprot:EUTK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EUTK_ECOLI ## Database ID URL or Descriptions # BioGrid 4259403 14 # EcoGene EG13879 yceM # GO_function GO:0016491 oxidoreductase activity; IBA:GO_Central. # GO_process GO:0055114 oxidation-reduction process; IBA:GO_Central. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.720 -; 1. # IntAct P75931 3 # InterPro IPR000683 Oxidoreductase_N # InterPro IPR016040 NAD(P)-bd_dom # Organism YCEM_ECOLI Escherichia coli (strain K12) # PATRIC 32117375 VBIEscCol129921_1110 # PDB 1TLT X-ray; 2.70 A; A/B=2-307 # PIR A64850 A64850 # Pfam PF01408 GFO_IDH_MocA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCEM_ECOLI Putative oxidoreductase YceM # RefSeq NP_415586 NC_000913.3 # RefSeq WP_000736158 NZ_LN832404.1 # SIMILARITY Belongs to the Gfo/Idh/MocA family. {ECO 0000305}. # SUPFAM SSF51735 SSF51735 # eggNOG COG0673 LUCA # eggNOG ENOG4105EP9 Bacteria BLAST swissprot:YCEM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCEM_ECOLI BioCyc ECOL316407:JW1055-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1055-MONOMER BioCyc EcoCyc:G6560-MONOMER http://biocyc.org/getid?id=EcoCyc:G6560-MONOMER COG COG0673 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0673 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- EchoBASE EB3638 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3638 EcoGene EG13879 http://www.ecogene.org/geneInfo.php?eg_id=EG13879 EnsemblBacteria AAC74152 http://www.ensemblgenomes.org/id/AAC74152 EnsemblBacteria AAC74152 http://www.ensemblgenomes.org/id/AAC74152 EnsemblBacteria BAA35876 http://www.ensemblgenomes.org/id/BAA35876 EnsemblBacteria BAA35876 http://www.ensemblgenomes.org/id/BAA35876 EnsemblBacteria BAA35876 http://www.ensemblgenomes.org/id/BAA35876 EnsemblBacteria b1068 http://www.ensemblgenomes.org/id/b1068 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_process GO:0055114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 945204 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945204 HOGENOM HOG000039102 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000039102&db=HOGENOM6 InParanoid P75931 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75931 IntAct P75931 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75931* IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR000683 http://www.ebi.ac.uk/interpro/entry/IPR000683 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 KEGG_Gene ecj:JW1055 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1055 KEGG_Gene eco:b1068 http://www.genome.jp/dbget-bin/www_bget?eco:b1068 KEGG_Orthology KO:K03810 http://www.genome.jp/dbget-bin/www_bget?KO:K03810 OMA VCQQYRI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VCQQYRI PDB 1TLT http://www.ebi.ac.uk/pdbe-srv/view/entry/1TLT PDBsum 1TLT http://www.ebi.ac.uk/pdbsum/1TLT PSORT swissprot:YCEM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCEM_ECOLI PSORT-B swissprot:YCEM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCEM_ECOLI PSORT2 swissprot:YCEM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCEM_ECOLI Pfam PF01408 http://pfam.xfam.org/family/PF01408 Phobius swissprot:YCEM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCEM_ECOLI PhylomeDB P75931 http://phylomedb.org/?seqid=P75931 ProteinModelPortal P75931 http://www.proteinmodelportal.org/query/uniprot/P75931 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415586 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415586 RefSeq WP_000736158 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000736158 SMR P75931 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75931 STRING 511145.b1068 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1068&targetmode=cogs STRING COG0673 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0673&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB YCEM_ECOLI http://www.uniprot.org/uniprot/YCEM_ECOLI UniProtKB-AC P75931 http://www.uniprot.org/uniprot/P75931 charge swissprot:YCEM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCEM_ECOLI eggNOG COG0673 http://eggnogapi.embl.de/nog_data/html/tree/COG0673 eggNOG ENOG4105EP9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EP9 epestfind swissprot:YCEM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCEM_ECOLI garnier swissprot:YCEM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCEM_ECOLI helixturnhelix swissprot:YCEM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCEM_ECOLI hmoment swissprot:YCEM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCEM_ECOLI iep swissprot:YCEM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCEM_ECOLI inforesidue swissprot:YCEM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCEM_ECOLI octanol swissprot:YCEM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCEM_ECOLI pepcoil swissprot:YCEM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCEM_ECOLI pepdigest swissprot:YCEM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCEM_ECOLI pepinfo swissprot:YCEM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCEM_ECOLI pepnet swissprot:YCEM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCEM_ECOLI pepstats swissprot:YCEM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCEM_ECOLI pepwheel swissprot:YCEM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCEM_ECOLI pepwindow swissprot:YCEM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCEM_ECOLI sigcleave swissprot:YCEM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCEM_ECOLI ## Database ID URL or Descriptions # BioGrid 4260530 3 # DISRUPTION PHENOTYPE Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain. {ECO:0000269|PubMed 20345943}. # EcoGene EG14120 yfcQ # FUNCTION YFCQ_ECOLI Part of the yfcOPQRSUV fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes. {ECO 0000269|PubMed 20345943}. # GO_component GO:0009289 pilus; IEA:InterPro. # GO_process GO:0007155 cell adhesion; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0007155 cell adhesion # Gene3D 2.60.40.1090 -; 1. # INDUCTION Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression. {ECO:0000269|PubMed 20345943}. # IntAct P76500 12 # InterPro IPR000259 Adhesion_dom_fimbrial # InterPro IPR008966 Adhesion_dom # MISCELLANEOUS The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed. {ECO:0000305|PubMed 20345943}. # Organism YFCQ_ECOLI Escherichia coli (strain K12) # PATRIC 32120041 VBIEscCol129921_2430 # PIR D65006 D65006 # Pfam PF00419 Fimbrial # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFCQ_ECOLI Uncharacterized fimbrial-like protein YfcQ # RefSeq NP_416837 NC_000913.3 # RefSeq WP_001232541 NZ_LN832404.1 # SIMILARITY Belongs to the fimbrial protein family. {ECO 0000305}. # SUPFAM SSF49401 SSF49401 # eggNOG ENOG4105UGQ Bacteria # eggNOG ENOG4111UC7 LUCA BLAST swissprot:YFCQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFCQ_ECOLI BioCyc ECOL316407:JW2331-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2331-MONOMER BioCyc EcoCyc:G7205-MONOMER http://biocyc.org/getid?id=EcoCyc:G7205-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1462-2920.2010.02202.x http://dx.doi.org/10.1111/j.1462-2920.2010.02202.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3873 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3873 EcoGene EG14120 http://www.ecogene.org/geneInfo.php?eg_id=EG14120 EnsemblBacteria AAC75394 http://www.ensemblgenomes.org/id/AAC75394 EnsemblBacteria AAC75394 http://www.ensemblgenomes.org/id/AAC75394 EnsemblBacteria BAE76691 http://www.ensemblgenomes.org/id/BAE76691 EnsemblBacteria BAE76691 http://www.ensemblgenomes.org/id/BAE76691 EnsemblBacteria BAE76691 http://www.ensemblgenomes.org/id/BAE76691 EnsemblBacteria b2334 http://www.ensemblgenomes.org/id/b2334 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009289 GO_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 Gene3D 2.60.40.1090 http://www.cathdb.info/version/latest/superfamily/2.60.40.1090 GeneID 946779 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946779 HOGENOM HOG000122523 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122523&db=HOGENOM6 IntAct P76500 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76500* InterPro IPR000259 http://www.ebi.ac.uk/interpro/entry/IPR000259 InterPro IPR008966 http://www.ebi.ac.uk/interpro/entry/IPR008966 KEGG_Gene ecj:JW2331 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2331 KEGG_Gene eco:b2334 http://www.genome.jp/dbget-bin/www_bget?eco:b2334 OMA TIDVEFG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TIDVEFG PSORT swissprot:YFCQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFCQ_ECOLI PSORT-B swissprot:YFCQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFCQ_ECOLI PSORT2 swissprot:YFCQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFCQ_ECOLI Pfam PF00419 http://pfam.xfam.org/family/PF00419 Phobius swissprot:YFCQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFCQ_ECOLI ProteinModelPortal P76500 http://www.proteinmodelportal.org/query/uniprot/P76500 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20345943 http://www.ncbi.nlm.nih.gov/pubmed/20345943 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416837 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416837 RefSeq WP_001232541 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001232541 STRING 511145.b2334 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2334&targetmode=cogs SUPFAM SSF49401 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49401 UniProtKB YFCQ_ECOLI http://www.uniprot.org/uniprot/YFCQ_ECOLI UniProtKB-AC P76500 http://www.uniprot.org/uniprot/P76500 charge swissprot:YFCQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFCQ_ECOLI eggNOG ENOG4105UGQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105UGQ eggNOG ENOG4111UC7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111UC7 epestfind swissprot:YFCQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFCQ_ECOLI garnier swissprot:YFCQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFCQ_ECOLI helixturnhelix swissprot:YFCQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFCQ_ECOLI hmoment swissprot:YFCQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFCQ_ECOLI iep swissprot:YFCQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFCQ_ECOLI inforesidue swissprot:YFCQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFCQ_ECOLI octanol swissprot:YFCQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFCQ_ECOLI pepcoil swissprot:YFCQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFCQ_ECOLI pepdigest swissprot:YFCQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFCQ_ECOLI pepinfo swissprot:YFCQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFCQ_ECOLI pepnet swissprot:YFCQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFCQ_ECOLI pepstats swissprot:YFCQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFCQ_ECOLI pepwheel swissprot:YFCQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFCQ_ECOLI pepwindow swissprot:YFCQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFCQ_ECOLI sigcleave swissprot:YFCQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFCQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4259577 7 # EcoGene EG10956 sohB # FUNCTION SOHB_ECOLI Multicopy suppressor of the HtrA (DegP) null phenotype. It is possibly a protease, not essential for bacterial viability. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0004252 serine-type endopeptidase activity; IEA:InterPro. # GO_process GO:0006508 proteolysis; IGI:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0008233 peptidase activity # GOslim_process GO:0008150 biological_process # Gene3D 3.90.226.10 -; 2. # IntAct P0AG14 3 # InterPro IPR002142 Peptidase_S49 # InterPro IPR013703 Peptidase_S49_N_proteobac # InterPro IPR029045 ClpP/crotonase-like_dom # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # Organism SOHB_ECOLI Escherichia coli (strain K12) # PATRIC 32117802 VBIEscCol129921_1321 # PIR C64875 C64875 # Pfam PF01343 Peptidase_S49 # Pfam PF08496 Peptidase_S49_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SOHB_ECOLI Probable protease SohB # RefSeq NP_415788 NC_000913.3 # RefSeq WP_000422045 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase S49 family. {ECO 0000305}. # SUBCELLULAR LOCATION SOHB_ECOLI Cell inner membrane; Single-pass membrane protein. # SUPFAM SSF52096 SSF52096; 2 # eggNOG COG0616 LUCA # eggNOG ENOG4105ERU Bacteria BLAST swissprot:SOHB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SOHB_ECOLI BioCyc ECOL316407:JW1264-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1264-MONOMER BioCyc EcoCyc:EG10956-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10956-MONOMER COG COG0616 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0616 DIP DIP-35930N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35930N DOI 10.1016/0022-2836(86)90129-4 http://dx.doi.org/10.1016/0022-2836(86)90129-4 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.21.- http://www.genome.jp/dbget-bin/www_bget?EC:3.4.21.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M73320 http://www.ebi.ac.uk/ena/data/view/M73320 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.4.21.- http://enzyme.expasy.org/EC/3.4.21.- EchoBASE EB0949 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0949 EcoGene EG10956 http://www.ecogene.org/geneInfo.php?eg_id=EG10956 EnsemblBacteria AAC74354 http://www.ensemblgenomes.org/id/AAC74354 EnsemblBacteria AAC74354 http://www.ensemblgenomes.org/id/AAC74354 EnsemblBacteria BAA14809 http://www.ensemblgenomes.org/id/BAA14809 EnsemblBacteria BAA14809 http://www.ensemblgenomes.org/id/BAA14809 EnsemblBacteria BAA14809 http://www.ensemblgenomes.org/id/BAA14809 EnsemblBacteria b1272 http://www.ensemblgenomes.org/id/b1272 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0004252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004252 GO_process GO:0006508 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006508 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.90.226.10 http://www.cathdb.info/version/latest/superfamily/3.90.226.10 GeneID 945858 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945858 HOGENOM HOG000281079 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000281079&db=HOGENOM6 InParanoid P0AG14 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AG14 IntAct P0AG14 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AG14* IntEnz 3.4.21 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.21 InterPro IPR002142 http://www.ebi.ac.uk/interpro/entry/IPR002142 InterPro IPR013703 http://www.ebi.ac.uk/interpro/entry/IPR013703 InterPro IPR029045 http://www.ebi.ac.uk/interpro/entry/IPR029045 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW1264 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1264 KEGG_Gene eco:b1272 http://www.genome.jp/dbget-bin/www_bget?eco:b1272 KEGG_Orthology KO:K04774 http://www.genome.jp/dbget-bin/www_bget?KO:K04774 OMA MACIGEK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MACIGEK PSORT swissprot:SOHB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SOHB_ECOLI PSORT-B swissprot:SOHB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SOHB_ECOLI PSORT2 swissprot:SOHB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SOHB_ECOLI Pfam PF01343 http://pfam.xfam.org/family/PF01343 Pfam PF08496 http://pfam.xfam.org/family/PF08496 Phobius swissprot:SOHB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SOHB_ECOLI PhylomeDB P0AG14 http://phylomedb.org/?seqid=P0AG14 ProteinModelPortal P0AG14 http://www.proteinmodelportal.org/query/uniprot/P0AG14 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1885549 http://www.ncbi.nlm.nih.gov/pubmed/1885549 PubMed 3029379 http://www.ncbi.nlm.nih.gov/pubmed/3029379 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415788 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415788 RefSeq WP_000422045 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000422045 SMR P0AG14 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AG14 STRING 511145.b1272 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1272&targetmode=cogs STRING COG0616 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0616&targetmode=cogs SUPFAM SSF52096 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52096 UniProtKB SOHB_ECOLI http://www.uniprot.org/uniprot/SOHB_ECOLI UniProtKB-AC P0AG14 http://www.uniprot.org/uniprot/P0AG14 charge swissprot:SOHB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SOHB_ECOLI eggNOG COG0616 http://eggnogapi.embl.de/nog_data/html/tree/COG0616 eggNOG ENOG4105ERU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ERU epestfind swissprot:SOHB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SOHB_ECOLI garnier swissprot:SOHB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SOHB_ECOLI helixturnhelix swissprot:SOHB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SOHB_ECOLI hmoment swissprot:SOHB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SOHB_ECOLI iep swissprot:SOHB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SOHB_ECOLI inforesidue swissprot:SOHB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SOHB_ECOLI octanol swissprot:SOHB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SOHB_ECOLI pepcoil swissprot:SOHB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SOHB_ECOLI pepdigest swissprot:SOHB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SOHB_ECOLI pepinfo swissprot:SOHB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SOHB_ECOLI pepnet swissprot:SOHB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SOHB_ECOLI pepstats swissprot:SOHB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SOHB_ECOLI pepwheel swissprot:SOHB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SOHB_ECOLI pepwindow swissprot:SOHB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SOHB_ECOLI sigcleave swissprot:SOHB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SOHB_ECOLI ## Database ID URL or Descriptions # AltName Topoisomerase IV subunit B {ECO:0000255|HAMAP-Rule MF_00938} # BioGrid 4262393 291 # CATALYTIC ACTIVITY PARE_ECOLI ATP-dependent breakage, passage and rejoining of double-stranded DNA. {ECO 0000255|HAMAP-Rule MF_00938, ECO 0000269|PubMed 15105144, ECO 0000269|PubMed 21300644}. # COFACTOR PARE_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_00938, ECO 0000269|PubMed 21300644}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000255|HAMAP-Rule MF_00938, ECO 0000269|PubMed 21300644}; Name=Ca(2+); Xref=ChEBI CHEBI 29108; Evidence={ECO 0000255|HAMAP-Rule MF_00938, ECO 0000269|PubMed 21300644}; Note=Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+). {ECO 0000255|HAMAP-Rule MF_00938, ECO 0000269|PubMed 21300644}; # ENZYME REGULATION Pyrrolopyrimidines inhibit both GyrB and its paralog in topoisomerase IV (parE) (PubMed:23294697). {ECO 0000269|PubMed:23294697}. # EcoGene EG10687 parE # FUNCTION PARE_ECOLI Topoisomerase IV is essential for chromosome segregation; it is the principal protein responsible for decatenating newly replicated chromosomes (PubMed 9334322). It relaxes supercoiled DNA (PubMed 15105144, PubMed 21300644, PubMed 23294697, PubMed 23352267). MukB stimulates the relaxation activity of topoisomerase IV and also has a modest effect on decatenation (PubMed 20921377). {ECO 0000269|PubMed 15105144, ECO 0000269|PubMed 20921377, ECO 0000269|PubMed 21300644, ECO 0000269|PubMed 23294697, ECO 0000269|PubMed 23352267, ECO 0000269|PubMed 9334322}. # GO_component GO:0005694 chromosome; IEA:InterPro. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0009295 nucleoid; IBA:GO_Central. # GO_component GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing); IBA:GO_Central. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity; IBA:GO_Central. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006265 DNA topological change; IBA:GO_Central. # GO_process GO:0006268 DNA unwinding involved in DNA replication; IBA:GO_Central. # GO_process GO:0007062 sister chromatid cohesion; IMP:EcoliWiki. # GO_process GO:0030541 plasmid partitioning; IDA:EcoliWiki. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GO_process GO:0051276 chromosome organization; IMP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005694 chromosome # GOslim_component GO:0005829 cytosol # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0051276 chromosome organization # Gene3D 3.30.230.10 -; 1. # Gene3D 3.30.565.10 -; 1. # Gene3D 3.40.50.670 -; 1. # HAMAP MF_00938 ParE_type1 # IntAct P20083 24 # InterPro IPR001241 Topo_IIA # InterPro IPR002288 DNA_gyrase_B_C # InterPro IPR003594 HATPase_C # InterPro IPR005737 TopoIV_B_Gneg # InterPro IPR006171 Toprim_domain # InterPro IPR013506 Topo_IIA_bsu_dom2 # InterPro IPR013759 Topo_IIA_cen_dom # InterPro IPR013760 Topo_IIA-like_dom # InterPro IPR014721 Ribosomal_S5_D2-typ_fold_subgr # InterPro IPR018522 TopoIIA_CS # InterPro IPR020568 Ribosomal_S5_D2-typ_fold # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03032 DNA replication proteins # KEGG_Brite ko03036 Chromosome # Organism PARE_ECOLI Escherichia coli (strain K12) # PATRIC 32121470 VBIEscCol129921_3122 # PDB 1S14 X-ray; 2.00 A; A/B=1-217 # PDB 1S16 X-ray; 2.10 A; A/B=1-390 # PDB 3FV5 X-ray; 1.80 A; A/B=15-215 # PDB 4HZ0 X-ray; 2.20 A; A/B=12-216 # PIR D65090 D65090 # PRINTS PR00418 TPI2FAMILY # PROSITE PS00177 TOPOISOMERASE_II # PROSITE PS50880 TOPRIM # Pfam PF00204 DNA_gyraseB # Pfam PF00986 DNA_gyraseB_C # Pfam PF01751 Toprim # Pfam PF02518 HATPase_c # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DNA topoisomerase 4 subunit B {ECO:0000255|HAMAP-Rule MF_00938} # RefSeq NP_417502 NC_000913.3 # RefSeq WP_000195296 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA24298.1; Type=Frameshift; Positions=597; Evidence={ECO 0000305}; # SIMILARITY Belongs to the type II topoisomerase family. ParE type 1 subfamily. {ECO:0000255|HAMAP-Rule MF_00938}. # SIMILARITY Contains 1 Toprim domain. {ECO:0000255|HAMAP- Rule MF_00938}. # SMART SM00387 HATPase_c # SMART SM00433 TOP2c # SUBUNIT PARE_ECOLI Heterotetramer composed of ParC and ParE. {ECO 0000255|HAMAP-Rule MF_00938, ECO 0000269|PubMed 15105144, ECO 0000269|PubMed 21300644}. # SUPFAM SSF54211 SSF54211 # SUPFAM SSF55874 SSF55874 # SUPFAM SSF56719 SSF56719 # TIGRFAMs TIGR01055 parE_Gneg # eggNOG COG0187 LUCA # eggNOG ENOG4105C7D Bacteria BLAST swissprot:PARE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PARE_ECOLI BioCyc ECOL316407:JW2998-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2998-MONOMER BioCyc EcoCyc:EG10687-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10687-MONOMER COG COG0187 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0187 DIP DIP-10441N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10441N DOI 10.1016/0092-8674(90)90172-B http://dx.doi.org/10.1016/0092-8674(90)90172-B DOI 10.1016/j.bmcl.2012.11.032 http://dx.doi.org/10.1016/j.bmcl.2012.11.032 DOI 10.1016/j.bmcl.2012.11.073 http://dx.doi.org/10.1016/j.bmcl.2012.11.073 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.1008678107 http://dx.doi.org/10.1073/pnas.1008678107 DOI 10.1093/nar/21.8.1805 http://dx.doi.org/10.1093/nar/21.8.1805 DOI 10.1093/nar/gkr018 http://dx.doi.org/10.1093/nar/gkr018 DOI 10.1101/gad.11.19.2580 http://dx.doi.org/10.1101/gad.11.19.2580 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AAC.48.5.1856-1864.2004 http://dx.doi.org/10.1128/AAC.48.5.1856-1864.2004 EC_number EC:5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_00938} http://www.genome.jp/dbget-bin/www_bget?EC:5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_00938} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L22026 http://www.ebi.ac.uk/ena/data/view/L22026 EMBL M58409 http://www.ebi.ac.uk/ena/data/view/M58409 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 ENZYME 5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_00938} http://enzyme.expasy.org/EC/5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_00938} EchoBASE EB0681 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0681 EcoGene EG10687 http://www.ecogene.org/geneInfo.php?eg_id=EG10687 EnsemblBacteria AAC76066 http://www.ensemblgenomes.org/id/AAC76066 EnsemblBacteria AAC76066 http://www.ensemblgenomes.org/id/AAC76066 EnsemblBacteria BAE77086 http://www.ensemblgenomes.org/id/BAE77086 EnsemblBacteria BAE77086 http://www.ensemblgenomes.org/id/BAE77086 EnsemblBacteria BAE77086 http://www.ensemblgenomes.org/id/BAE77086 EnsemblBacteria b3030 http://www.ensemblgenomes.org/id/b3030 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005694 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005694 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0009295 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009295 GO_component GO:0009330 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009330 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003918 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003918 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006265 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006265 GO_process GO:0006268 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006268 GO_process GO:0007062 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007062 GO_process GO:0030541 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030541 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GO_process GO:0051276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051276 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005694 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005694 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0051276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051276 Gene3D 3.30.230.10 http://www.cathdb.info/version/latest/superfamily/3.30.230.10 Gene3D 3.30.565.10 http://www.cathdb.info/version/latest/superfamily/3.30.565.10 Gene3D 3.40.50.670 http://www.cathdb.info/version/latest/superfamily/3.40.50.670 GeneID 947501 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947501 HAMAP MF_00938 http://hamap.expasy.org/unirule/MF_00938 HOGENOM HOG000075154 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000075154&db=HOGENOM6 InParanoid P20083 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P20083 IntAct P20083 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P20083* IntEnz 5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_00938} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_00938} InterPro IPR001241 http://www.ebi.ac.uk/interpro/entry/IPR001241 InterPro IPR002288 http://www.ebi.ac.uk/interpro/entry/IPR002288 InterPro IPR003594 http://www.ebi.ac.uk/interpro/entry/IPR003594 InterPro IPR005737 http://www.ebi.ac.uk/interpro/entry/IPR005737 InterPro IPR006171 http://www.ebi.ac.uk/interpro/entry/IPR006171 InterPro IPR013506 http://www.ebi.ac.uk/interpro/entry/IPR013506 InterPro IPR013759 http://www.ebi.ac.uk/interpro/entry/IPR013759 InterPro IPR013760 http://www.ebi.ac.uk/interpro/entry/IPR013760 InterPro IPR014721 http://www.ebi.ac.uk/interpro/entry/IPR014721 InterPro IPR018522 http://www.ebi.ac.uk/interpro/entry/IPR018522 InterPro IPR020568 http://www.ebi.ac.uk/interpro/entry/IPR020568 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03032 http://www.genome.jp/dbget-bin/www_bget?ko03032 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene ecj:JW2998 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2998 KEGG_Gene eco:b3030 http://www.genome.jp/dbget-bin/www_bget?eco:b3030 KEGG_Orthology KO:K02622 http://www.genome.jp/dbget-bin/www_bget?KO:K02622 MINT MINT-1223307 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1223307 OMA DENERDA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DENERDA PDB 1S14 http://www.ebi.ac.uk/pdbe-srv/view/entry/1S14 PDB 1S16 http://www.ebi.ac.uk/pdbe-srv/view/entry/1S16 PDB 3FV5 http://www.ebi.ac.uk/pdbe-srv/view/entry/3FV5 PDB 4HZ0 http://www.ebi.ac.uk/pdbe-srv/view/entry/4HZ0 PDBsum 1S14 http://www.ebi.ac.uk/pdbsum/1S14 PDBsum 1S16 http://www.ebi.ac.uk/pdbsum/1S16 PDBsum 3FV5 http://www.ebi.ac.uk/pdbsum/3FV5 PDBsum 4HZ0 http://www.ebi.ac.uk/pdbsum/4HZ0 PRINTS PR00418 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00418 PROSITE PS00177 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00177 PROSITE PS50880 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50880 PSORT swissprot:PARE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PARE_ECOLI PSORT-B swissprot:PARE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PARE_ECOLI PSORT2 swissprot:PARE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PARE_ECOLI Pfam PF00204 http://pfam.xfam.org/family/PF00204 Pfam PF00986 http://pfam.xfam.org/family/PF00986 Pfam PF01751 http://pfam.xfam.org/family/PF01751 Pfam PF02518 http://pfam.xfam.org/family/PF02518 Phobius swissprot:PARE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PARE_ECOLI PhylomeDB P20083 http://phylomedb.org/?seqid=P20083 ProteinModelPortal P20083 http://www.proteinmodelportal.org/query/uniprot/P20083 PubMed 15105144 http://www.ncbi.nlm.nih.gov/pubmed/15105144 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20921377 http://www.ncbi.nlm.nih.gov/pubmed/20921377 PubMed 21300644 http://www.ncbi.nlm.nih.gov/pubmed/21300644 PubMed 2170028 http://www.ncbi.nlm.nih.gov/pubmed/2170028 PubMed 23294697 http://www.ncbi.nlm.nih.gov/pubmed/23294697 PubMed 23352267 http://www.ncbi.nlm.nih.gov/pubmed/23352267 PubMed 8227000 http://www.ncbi.nlm.nih.gov/pubmed/8227000 PubMed 8388096 http://www.ncbi.nlm.nih.gov/pubmed/8388096 PubMed 8980775 http://www.ncbi.nlm.nih.gov/pubmed/8980775 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9334322 http://www.ncbi.nlm.nih.gov/pubmed/9334322 RefSeq NP_417502 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417502 RefSeq WP_000195296 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000195296 SMART SM00387 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00387 SMART SM00433 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00433 SMR P20083 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P20083 STRING 511145.b3030 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3030&targetmode=cogs STRING COG0187 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0187&targetmode=cogs SUPFAM SSF54211 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54211 SUPFAM SSF55874 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55874 SUPFAM SSF56719 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56719 TIGRFAMs TIGR01055 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01055 UniProtKB PARE_ECOLI http://www.uniprot.org/uniprot/PARE_ECOLI UniProtKB-AC P20083 http://www.uniprot.org/uniprot/P20083 charge swissprot:PARE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PARE_ECOLI eggNOG COG0187 http://eggnogapi.embl.de/nog_data/html/tree/COG0187 eggNOG ENOG4105C7D http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C7D epestfind swissprot:PARE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PARE_ECOLI garnier swissprot:PARE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PARE_ECOLI helixturnhelix swissprot:PARE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PARE_ECOLI hmoment swissprot:PARE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PARE_ECOLI iep swissprot:PARE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PARE_ECOLI inforesidue swissprot:PARE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PARE_ECOLI octanol swissprot:PARE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PARE_ECOLI pepcoil swissprot:PARE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PARE_ECOLI pepdigest swissprot:PARE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PARE_ECOLI pepinfo swissprot:PARE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PARE_ECOLI pepnet swissprot:PARE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PARE_ECOLI pepstats swissprot:PARE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PARE_ECOLI pepwheel swissprot:PARE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PARE_ECOLI pepwindow swissprot:PARE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PARE_ECOLI sigcleave swissprot:PARE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PARE_ECOLI ## Database ID URL or Descriptions # BioGrid 4262668 66 # EcoGene EG11935 yjbQ # Gene3D 2.60.120.460 -; 1. # InterPro IPR001602 UPF0047 # Organism YJBQ_ECOLI Escherichia coli (strain K12) # PATRIC 32123657 VBIEscCol129921_4177 # PIR G65213 G65213 # PIRSF PIRSF004681 UCP004681 # PROSITE PS01314 UPF0047 # Pfam PF01894 UPF0047 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJBQ_ECOLI UPF0047 protein YjbQ # RefSeq NP_418480 NC_000913.3 # RefSeq WP_000270375 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0047 family. {ECO 0000305}. # SUPFAM SSF111038 SSF111038 # TIGRFAMs TIGR00149 TIGR00149_YjbQ # eggNOG COG0432 LUCA # eggNOG ENOG4108YXI Bacteria BLAST swissprot:YJBQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJBQ_ECOLI BioCyc ECOL316407:JW4017-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4017-MONOMER BioCyc EcoCyc:EG11935-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11935-MONOMER DIP DIP-48208N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48208N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1879 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1879 EcoGene EG11935 http://www.ecogene.org/geneInfo.php?eg_id=EG11935 EnsemblBacteria AAC77026 http://www.ensemblgenomes.org/id/AAC77026 EnsemblBacteria AAC77026 http://www.ensemblgenomes.org/id/AAC77026 EnsemblBacteria BAE78058 http://www.ensemblgenomes.org/id/BAE78058 EnsemblBacteria BAE78058 http://www.ensemblgenomes.org/id/BAE78058 EnsemblBacteria BAE78058 http://www.ensemblgenomes.org/id/BAE78058 EnsemblBacteria b4056 http://www.ensemblgenomes.org/id/b4056 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 2.60.120.460 http://www.cathdb.info/version/latest/superfamily/2.60.120.460 GeneID 948561 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948561 HOGENOM HOG000123401 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000123401&db=HOGENOM6 InParanoid P0AF48 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AF48 InterPro IPR001602 http://www.ebi.ac.uk/interpro/entry/IPR001602 KEGG_Gene ecj:JW4017 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4017 KEGG_Gene eco:b4056 http://www.genome.jp/dbget-bin/www_bget?eco:b4056 OMA PERAPYY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PERAPYY PROSITE PS01314 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01314 PSORT swissprot:YJBQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJBQ_ECOLI PSORT-B swissprot:YJBQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJBQ_ECOLI PSORT2 swissprot:YJBQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJBQ_ECOLI Pfam PF01894 http://pfam.xfam.org/family/PF01894 Phobius swissprot:YJBQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJBQ_ECOLI PhylomeDB P0AF48 http://phylomedb.org/?seqid=P0AF48 ProteinModelPortal P0AF48 http://www.proteinmodelportal.org/query/uniprot/P0AF48 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418480 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418480 RefSeq WP_000270375 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000270375 SMR P0AF48 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AF48 STRING 511145.b4056 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4056&targetmode=cogs SUPFAM SSF111038 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF111038 TIGRFAMs TIGR00149 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00149 UniProtKB YJBQ_ECOLI http://www.uniprot.org/uniprot/YJBQ_ECOLI UniProtKB-AC P0AF48 http://www.uniprot.org/uniprot/P0AF48 charge swissprot:YJBQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJBQ_ECOLI eggNOG COG0432 http://eggnogapi.embl.de/nog_data/html/tree/COG0432 eggNOG ENOG4108YXI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108YXI epestfind swissprot:YJBQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJBQ_ECOLI garnier swissprot:YJBQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJBQ_ECOLI helixturnhelix swissprot:YJBQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJBQ_ECOLI hmoment swissprot:YJBQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJBQ_ECOLI iep swissprot:YJBQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJBQ_ECOLI inforesidue swissprot:YJBQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJBQ_ECOLI octanol swissprot:YJBQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJBQ_ECOLI pepcoil swissprot:YJBQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJBQ_ECOLI pepdigest swissprot:YJBQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJBQ_ECOLI pepinfo swissprot:YJBQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJBQ_ECOLI pepnet swissprot:YJBQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJBQ_ECOLI pepstats swissprot:YJBQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJBQ_ECOLI pepwheel swissprot:YJBQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJBQ_ECOLI pepwindow swissprot:YJBQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJBQ_ECOLI sigcleave swissprot:YJBQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJBQ_ECOLI ## Database ID URL or Descriptions # AltName RLMN_ECOLI 23S rRNA (adenine(2503)-C(2))-methyltransferase # AltName RLMN_ECOLI 23S rRNA m2A2503 methyltransferase # AltName RLMN_ECOLI Ribosomal RNA large subunit methyltransferase N # AltName RLMN_ECOLI tRNA (adenine(37)-C(2))-methyltransferase # AltName RLMN_ECOLI tRNA m2A37 methyltransferase # BRENDA 2.1.1.192 2165 # BioGrid 4261302 15 # CATALYTIC ACTIVITY RLMN_ECOLI 2 S-adenosyl-L-methionine + adenine(2503) in 23S rRNA + 2 reduced [2Fe-2S] ferredoxin = S-adenosyl-L- homocysteine + L-methionine + 5'-deoxyadenosine + 2- methyladenine(2503) in 23S rRNA + 2 oxidized [2Fe-2S] ferredoxin. {ECO 0000269|PubMed 18025251, ECO 0000269|PubMed 21415317, ECO 0000269|PubMed 22891362, ECO 0000269|PubMed 24806349}. # CATALYTIC ACTIVITY RLMN_ECOLI 2 S-adenosyl-L-methionine + adenine(37) in tRNA + 2 reduced [2Fe-2S] ferredoxin = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine(37) in tRNA + 2 oxidized [2Fe-2S] ferredoxin. {ECO 0000269|PubMed 18025251, ECO 0000269|PubMed 21415317, ECO 0000269|PubMed 22891362, ECO 0000269|PubMed 24806349}. # COFACTOR RLMN_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000269|PubMed 21527678, ECO 0000269|PubMed 21916495}; Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. {ECO 0000269|PubMed 21527678, ECO 0000269|PubMed 21916495}; # DISRUPTION PHENOTYPE RLMN_ECOLI Cells lacking this gene lack nucleoside m2A in both rRNA and tRNAs. Inactivation of rlmN produces an error- prone phenotype since it increases the misreading of a UAG stop codon, and thus decreases translational accuracy. Also leads to increased susceptibility to tiamulin, hygromycin A and sparsomycin. {ECO 0000269|PubMed 18025251, ECO 0000269|PubMed 22891362}. # EcoGene EG12401 rlmN # FUNCTION RLMN_ECOLI Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity. Unmodified tRNA is not a suitable substrate for RlmN, which suggests that RlmN works in a late step during tRNA maturation. {ECO 0000269|PubMed 18025251, ECO 0000269|PubMed 21415317, ECO 0000269|PubMed 22891362}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000049 tRNA binding; IDA:UniProtKB. # GO_function GO:0002935 tRNA (adenine-C2-)-methyltransferase activity; IDA:UniProtKB. # GO_function GO:0019843 rRNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IDA:EcoCyc. # GO_function GO:0070040 rRNA (adenine-C2-)-methyltransferase activity; IDA:EcoCyc. # GO_process GO:0030488 tRNA methylation; IDA:UniProtKB. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GO_process GO:0070475 rRNA base methylation; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0008168 methyltransferase activity # GOslim_function GO:0019843 rRNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.20.20.70 -; 1. # HAMAP MF_01849 RNA_methyltr_RlmN # INTERACTION RLMN_ECOLI P0A9A6 ftsZ; NbExp=3; IntAct=EBI-559071, EBI-370963; P02413 rplO; NbExp=3; IntAct=EBI-559071, EBI-543017; P21507 srmB; NbExp=3; IntAct=EBI-559071, EBI-546628; # IntAct P36979 94 # InterPro IPR004383 rRNA_lsu_MTrfase_RlmN/Cfr # InterPro IPR007197 rSAM # InterPro IPR013785 Aldolase_TIM # InterPro IPR027492 RNA_MTrfase_RlmN # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # MISCELLANEOUS RLMN_ECOLI Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue. In details, the methyl group from one SAM molecule is initially transferred to Cys-355 in a typical SN2 displacement. Then a 5'-dA radical formed from a second molecule of SAM abstracts a hydrogen from the methyl group of mCys-355, and the resulting Cys-appended methyl radical attacks the substrate adenine ring. Methyl transfer to C2 thus results in a covalent adduct between the substrate and Cys-355, which is resolved by formation of a disulfide bond between Cys-355 and a second conserved Cys residue (Cys-118). # Organism RLMN_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30544 PTHR30544 # PATRIC 32120427 VBIEscCol129921_2616 # PDB 3RF9 X-ray; 2.20 A; A/B=1-384 # PDB 3RFA X-ray; 2.05 A; A/B=1-384 # PDB 5HR6 X-ray; 2.88 A; A/B=1-384 # PDB 5HR7 X-ray; 2.40 A; A/B=1-384 # PIR D65028 D65028 # PIRSF PIRSF006004 CHP00048 # Pfam PF04055 Radical_SAM # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RLMN_ECOLI Dual-specificity RNA methyltransferase RlmN # RefSeq NP_417012 NC_000913.3 # RefSeq WP_000003317 NZ_LN832404.1 # SIMILARITY Belongs to the radical SAM superfamily. RlmN family. {ECO 0000305}. # SUBCELLULAR LOCATION RLMN_ECOLI Cytoplasm {ECO 0000305}. # TIGRFAMs TIGR00048 rRNA_mod_RlmN # eggNOG COG0820 LUCA # eggNOG ENOG4105C55 Bacteria BLAST swissprot:RLMN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RLMN_ECOLI BioCyc ECOL316407:JW2501-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2501-MONOMER BioCyc EcoCyc:EG12401-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12401-MONOMER BioCyc MetaCyc:EG12401-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12401-MONOMER COG COG0820 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0820 DIP DIP-12035N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12035N DOI 10.1021/ja207327v http://dx.doi.org/10.1021/ja207327v DOI 10.1021/ja410560p http://dx.doi.org/10.1021/ja410560p DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1574-6968.1994.tb07115.x http://dx.doi.org/10.1111/j.1574-6968.1994.tb07115.x DOI 10.1126/science.1200877 http://dx.doi.org/10.1126/science.1200877 DOI 10.1126/science.1205358 http://dx.doi.org/10.1126/science.1205358 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1261/rna.033266.112 http://dx.doi.org/10.1261/rna.033266.112 DOI 10.1261/rna.814408 http://dx.doi.org/10.1261/rna.814408 EC_number EC:2.1.1.192 {ECO:0000269|PubMed:18025251, ECO:0000269|PubMed:21415317, ECO:0000269|PubMed:22891362, ECO:0000269|PubMed:24806349} http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.192 {ECO:0000269|PubMed:18025251, ECO:0000269|PubMed:21415317, ECO:0000269|PubMed:22891362, ECO:0000269|PubMed:24806349} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U02965 http://www.ebi.ac.uk/ena/data/view/U02965 ENZYME 2.1.1.192 {ECO:0000269|PubMed:18025251, ECO:0000269|PubMed:21415317, ECO:0000269|PubMed:22891362, ECO:0000269|PubMed:24806349} http://enzyme.expasy.org/EC/2.1.1.192 {ECO:0000269|PubMed:18025251, ECO:0000269|PubMed:21415317, ECO:0000269|PubMed:22891362, ECO:0000269|PubMed:24806349} EchoBASE EB2301 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2301 EcoGene EG12401 http://www.ecogene.org/geneInfo.php?eg_id=EG12401 EnsemblBacteria AAC75570 http://www.ensemblgenomes.org/id/AAC75570 EnsemblBacteria AAC75570 http://www.ensemblgenomes.org/id/AAC75570 EnsemblBacteria BAA16404 http://www.ensemblgenomes.org/id/BAA16404 EnsemblBacteria BAA16404 http://www.ensemblgenomes.org/id/BAA16404 EnsemblBacteria BAA16404 http://www.ensemblgenomes.org/id/BAA16404 EnsemblBacteria b2517 http://www.ensemblgenomes.org/id/b2517 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000049 GO_function GO:0002935 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002935 GO_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_function GO:0070040 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070040 GO_process GO:0030488 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030488 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GO_process GO:0070475 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070475 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 946249 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946249 HAMAP MF_01849 http://hamap.expasy.org/unirule/MF_01849 HOGENOM HOG000217992 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000217992&db=HOGENOM6 InParanoid P36979 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P36979 IntAct P36979 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P36979* IntEnz 2.1.1.192 {ECO:0000269|PubMed:18025251, ECO:0000269|PubMed:21415317, ECO:0000269|PubMed:22891362, ECO:0000269|PubMed:24806349} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.192 {ECO:0000269|PubMed:18025251, ECO:0000269|PubMed:21415317, ECO:0000269|PubMed:22891362, ECO:0000269|PubMed:24806349} InterPro IPR004383 http://www.ebi.ac.uk/interpro/entry/IPR004383 InterPro IPR007197 http://www.ebi.ac.uk/interpro/entry/IPR007197 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR027492 http://www.ebi.ac.uk/interpro/entry/IPR027492 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW2501 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2501 KEGG_Gene eco:b2517 http://www.genome.jp/dbget-bin/www_bget?eco:b2517 KEGG_Orthology KO:K06941 http://www.genome.jp/dbget-bin/www_bget?KO:K06941 MINT MINT-1220055 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1220055 OMA IYHFGVS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IYHFGVS PANTHER PTHR30544 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30544 PDB 3RF9 http://www.ebi.ac.uk/pdbe-srv/view/entry/3RF9 PDB 3RFA http://www.ebi.ac.uk/pdbe-srv/view/entry/3RFA PDB 5HR6 http://www.ebi.ac.uk/pdbe-srv/view/entry/5HR6 PDB 5HR7 http://www.ebi.ac.uk/pdbe-srv/view/entry/5HR7 PDBsum 3RF9 http://www.ebi.ac.uk/pdbsum/3RF9 PDBsum 3RFA http://www.ebi.ac.uk/pdbsum/3RFA PDBsum 5HR6 http://www.ebi.ac.uk/pdbsum/5HR6 PDBsum 5HR7 http://www.ebi.ac.uk/pdbsum/5HR7 PSORT swissprot:RLMN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RLMN_ECOLI PSORT-B swissprot:RLMN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RLMN_ECOLI PSORT2 swissprot:RLMN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RLMN_ECOLI Pfam PF04055 http://pfam.xfam.org/family/PF04055 Phobius swissprot:RLMN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RLMN_ECOLI PhylomeDB P36979 http://phylomedb.org/?seqid=P36979 ProteinModelPortal P36979 http://www.proteinmodelportal.org/query/uniprot/P36979 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18025251 http://www.ncbi.nlm.nih.gov/pubmed/18025251 PubMed 21415317 http://www.ncbi.nlm.nih.gov/pubmed/21415317 PubMed 21527678 http://www.ncbi.nlm.nih.gov/pubmed/21527678 PubMed 21916495 http://www.ncbi.nlm.nih.gov/pubmed/21916495 PubMed 22891362 http://www.ncbi.nlm.nih.gov/pubmed/22891362 PubMed 24806349 http://www.ncbi.nlm.nih.gov/pubmed/24806349 PubMed 7926684 http://www.ncbi.nlm.nih.gov/pubmed/7926684 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417012 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417012 RefSeq WP_000003317 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000003317 SMR P36979 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P36979 STRING 511145.b2517 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2517&targetmode=cogs STRING COG0820 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0820&targetmode=cogs TIGRFAMs TIGR00048 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00048 UniProtKB RLMN_ECOLI http://www.uniprot.org/uniprot/RLMN_ECOLI UniProtKB-AC P36979 http://www.uniprot.org/uniprot/P36979 charge swissprot:RLMN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RLMN_ECOLI eggNOG COG0820 http://eggnogapi.embl.de/nog_data/html/tree/COG0820 eggNOG ENOG4105C55 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C55 epestfind swissprot:RLMN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RLMN_ECOLI garnier swissprot:RLMN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RLMN_ECOLI helixturnhelix swissprot:RLMN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RLMN_ECOLI hmoment swissprot:RLMN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RLMN_ECOLI iep swissprot:RLMN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RLMN_ECOLI inforesidue swissprot:RLMN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RLMN_ECOLI octanol swissprot:RLMN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RLMN_ECOLI pepcoil swissprot:RLMN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RLMN_ECOLI pepdigest swissprot:RLMN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RLMN_ECOLI pepinfo swissprot:RLMN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RLMN_ECOLI pepnet swissprot:RLMN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RLMN_ECOLI pepstats swissprot:RLMN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RLMN_ECOLI pepwheel swissprot:RLMN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RLMN_ECOLI pepwindow swissprot:RLMN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RLMN_ECOLI sigcleave swissprot:RLMN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RLMN_ECOLI ## Database ID URL or Descriptions # BioGrid 4260581 4 # EcoGene EG14197 ypfJ # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # InterPro IPR007343 Uncharacterised_pept_Zn_put # Organism YPFJ_ECOLI Escherichia coli (strain K12) # PATRIC 32120335 VBIEscCol129921_2570 # PIR B65023 B65023 # Pfam PF04228 Zn_peptidase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YPFJ_ECOLI Uncharacterized protein YpfJ # RefSeq NP_416970 NC_000913.3 # RefSeq WP_001267498 NZ_LN832404.1 # SUBCELLULAR LOCATION YPFJ_ECOLI Membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. # eggNOG COG2321 LUCA # eggNOG ENOG4105CGZ Bacteria BLAST swissprot:YPFJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YPFJ_ECOLI BioCyc ECOL316407:JW2460-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2460-MONOMER BioCyc EcoCyc:G7298-MONOMER http://biocyc.org/getid?id=EcoCyc:G7298-MONOMER COG COG2321 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2321 DIP DIP-48230N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48230N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3949 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3949 EcoGene EG14197 http://www.ecogene.org/geneInfo.php?eg_id=EG14197 EnsemblBacteria AAC75528 http://www.ensemblgenomes.org/id/AAC75528 EnsemblBacteria AAC75528 http://www.ensemblgenomes.org/id/AAC75528 EnsemblBacteria BAE76723 http://www.ensemblgenomes.org/id/BAE76723 EnsemblBacteria BAE76723 http://www.ensemblgenomes.org/id/BAE76723 EnsemblBacteria BAE76723 http://www.ensemblgenomes.org/id/BAE76723 EnsemblBacteria b2475 http://www.ensemblgenomes.org/id/b2475 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GeneID 946956 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946956 HOGENOM HOG000210564 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000210564&db=HOGENOM6 InParanoid P64429 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P64429 InterPro IPR007343 http://www.ebi.ac.uk/interpro/entry/IPR007343 KEGG_Gene ecj:JW2460 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2460 KEGG_Gene eco:b2475 http://www.genome.jp/dbget-bin/www_bget?eco:b2475 KEGG_Orthology KO:K07054 http://www.genome.jp/dbget-bin/www_bget?KO:K07054 OMA QKRSQGY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QKRSQGY PSORT swissprot:YPFJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YPFJ_ECOLI PSORT-B swissprot:YPFJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YPFJ_ECOLI PSORT2 swissprot:YPFJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YPFJ_ECOLI Pfam PF04228 http://pfam.xfam.org/family/PF04228 Phobius swissprot:YPFJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YPFJ_ECOLI PhylomeDB P64429 http://phylomedb.org/?seqid=P64429 ProteinModelPortal P64429 http://www.proteinmodelportal.org/query/uniprot/P64429 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416970 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416970 RefSeq WP_001267498 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001267498 SMR P64429 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P64429 STRING 511145.b2475 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2475&targetmode=cogs STRING COG2321 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2321&targetmode=cogs UniProtKB YPFJ_ECOLI http://www.uniprot.org/uniprot/YPFJ_ECOLI UniProtKB-AC P64429 http://www.uniprot.org/uniprot/P64429 charge swissprot:YPFJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YPFJ_ECOLI eggNOG COG2321 http://eggnogapi.embl.de/nog_data/html/tree/COG2321 eggNOG ENOG4105CGZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CGZ epestfind swissprot:YPFJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YPFJ_ECOLI garnier swissprot:YPFJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YPFJ_ECOLI helixturnhelix swissprot:YPFJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YPFJ_ECOLI hmoment swissprot:YPFJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YPFJ_ECOLI iep swissprot:YPFJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YPFJ_ECOLI inforesidue swissprot:YPFJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YPFJ_ECOLI octanol swissprot:YPFJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YPFJ_ECOLI pepcoil swissprot:YPFJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YPFJ_ECOLI pepdigest swissprot:YPFJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YPFJ_ECOLI pepinfo swissprot:YPFJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YPFJ_ECOLI pepnet swissprot:YPFJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YPFJ_ECOLI pepstats swissprot:YPFJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YPFJ_ECOLI pepwheel swissprot:YPFJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YPFJ_ECOLI pepwindow swissprot:YPFJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YPFJ_ECOLI sigcleave swissprot:YPFJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YPFJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4259682 183 # CATALYTIC ACTIVITY YEGE_ECOLI 2 GTP = 2 diphosphate + cyclic di-3',5'- guanylate. # CDD cd01949 GGDEF # COFACTOR YEGE_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250}; Note=Binds 1 Mg(2+) ion per monomer. {ECO 0000250}; # DISRUPTION PHENOTYPE YEGE_ECOLI Decreased biofilm formation, decreased expression of AdrA, a probable diguanylate cyclase and of the curli regulator CsgD (PubMed 19332833). Disruption leads to decreaseded expression of adhesive curli fimbriae genes (PubMed 18765794). Also partially suppresses the reduced motility of a yhjH disruption; concomitant disruption of dosC, yegE, yedQ and yfiN completely restores motility, suggesting these 4 genes, together with the c-di-GMP phosphodiesterase YhjH, form a network that regulates cell motility by altering levels of c-di-GMP. {ECO 0000269|PubMed 18765794, ECO 0000269|PubMed 19332833, ECO 0000269|PubMed 20303158}. # EcoGene EG12396 yegE # FUNCTION YEGE_ECOLI Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria. {ECO 0000269|PubMed 20303158}. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_function GO:0000155 phosphorelay sensor kinase activity; IEA:InterPro. # GO_function GO:0005525 GTP binding; IEA:UniProtKB-KW. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0052621 diguanylate cyclase activity; IEA:UniProtKB-EC. # GOslim_component GO:0005622 intracellular # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0043167 ion binding # Gene3D 3.20.20.450 -; 1. # INDUCTION Expressed during transition into stationary phase, expression is equal at 28 and 37 degrees Celsius. Expression is RpoS dependent. {ECO:0000269|PubMed 19332833}. # InterPro IPR000014 PAS # InterPro IPR000160 GGDEF_dom # InterPro IPR000700 PAS-assoc_C # InterPro IPR001610 PAC # InterPro IPR001633 EAL_dom # InterPro IPR007895 MASE1 # InterPro IPR013655 PAS_fold_3 # InterPro IPR013656 PAS_4 # InterPro IPR029787 Nucleotide_cyclase # Organism YEGE_ECOLI Escherichia coli (strain K12) # PATHWAY YEGE_ECOLI Purine metabolism; 3',5'-cyclic di-GMP biosynthesis. # PATRIC 32119467 VBIEscCol129921_2144 # PIR B64973 B64973 # PROSITE PS50112 PAS; 2 # PROSITE PS50113 PAC; 3 # PROSITE PS50883 EAL # PROSITE PS50887 GGDEF # Pfam PF00563 EAL # Pfam PF00990 GGDEF # Pfam PF05231 MASE1 # Pfam PF08447 PAS_3 # Pfam PF08448 PAS_4 # Pfam PF13426 PAS_9 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEGE_ECOLI Probable diguanylate cyclase YegE # RefSeq NP_416571 NC_000913.3 # RefSeq WP_000043761 NZ_LN832404.1 # SIMILARITY Contains 1 EAL domain. {ECO:0000255|PROSITE- ProRule PRU00074}. # SIMILARITY Contains 1 GGDEF domain. {ECO:0000255|PROSITE- ProRule PRU00095}. # SIMILARITY Contains 2 PAS (PER-ARNT-SIM) domains. {ECO:0000255|PROSITE-ProRule PRU00140}. # SIMILARITY Contains 3 PAC (PAS-associated C-terminal) domains. {ECO:0000255|PROSITE-ProRule PRU00141}. # SMART SM00052 EAL # SMART SM00086 PAC; 3 # SMART SM00091 PAS; 3 # SMART SM00267 GGDEF # SUBUNIT Homodimer. {ECO 0000250}. # SUPFAM SSF141868 SSF141868 # SUPFAM SSF55073 SSF55073 # SUPFAM SSF55785 SSF55785; 3 # TIGRFAMs TIGR00229 sensory_box; 2 # TIGRFAMs TIGR00254 GGDEF # eggNOG COG2202 LUCA # eggNOG COG3447 LUCA # eggNOG ENOG4105BZU Bacteria BLAST swissprot:YEGE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEGE_ECOLI BioCyc ECOL316407:JW2052-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2052-MONOMER BioCyc EcoCyc:EG12396-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12396-MONOMER DOI 10.1016/j.cell.2010.01.018 http://dx.doi.org/10.1016/j.cell.2010.01.018 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1099/mic.0.024257-0 http://dx.doi.org/10.1099/mic.0.024257-0 DOI 10.1101/gad.475808 http://dx.doi.org/10.1101/gad.475808 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.7.65 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.65 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K02498 http://www.ebi.ac.uk/ena/data/view/K02498 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.7.65 http://enzyme.expasy.org/EC/2.7.7.65 EchoBASE EB2297 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2297 EcoGene EG12396 http://www.ecogene.org/geneInfo.php?eg_id=EG12396 EnsemblBacteria AAC75128 http://www.ensemblgenomes.org/id/AAC75128 EnsemblBacteria AAC75128 http://www.ensemblgenomes.org/id/AAC75128 EnsemblBacteria BAA15920 http://www.ensemblgenomes.org/id/BAA15920 EnsemblBacteria BAA15920 http://www.ensemblgenomes.org/id/BAA15920 EnsemblBacteria BAA15920 http://www.ensemblgenomes.org/id/BAA15920 EnsemblBacteria b2067 http://www.ensemblgenomes.org/id/b2067 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0000155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000155 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0052621 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052621 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.20.20.450 http://www.cathdb.info/version/latest/superfamily/3.20.20.450 GeneID 946600 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946600 HOGENOM HOG000122009 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122009&db=HOGENOM6 InParanoid P38097 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P38097 IntAct P38097 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P38097* IntEnz 2.7.7.65 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.65 InterPro IPR000014 http://www.ebi.ac.uk/interpro/entry/IPR000014 InterPro IPR000160 http://www.ebi.ac.uk/interpro/entry/IPR000160 InterPro IPR000700 http://www.ebi.ac.uk/interpro/entry/IPR000700 InterPro IPR001610 http://www.ebi.ac.uk/interpro/entry/IPR001610 InterPro IPR001633 http://www.ebi.ac.uk/interpro/entry/IPR001633 InterPro IPR007895 http://www.ebi.ac.uk/interpro/entry/IPR007895 InterPro IPR013655 http://www.ebi.ac.uk/interpro/entry/IPR013655 InterPro IPR013656 http://www.ebi.ac.uk/interpro/entry/IPR013656 InterPro IPR029787 http://www.ebi.ac.uk/interpro/entry/IPR029787 KEGG_Gene ecj:JW2052 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2052 KEGG_Gene eco:b2067 http://www.genome.jp/dbget-bin/www_bget?eco:b2067 OMA IRIDERF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IRIDERF PROSITE PS50112 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50112 PROSITE PS50113 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50113 PROSITE PS50883 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50883 PROSITE PS50887 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50887 PSORT swissprot:YEGE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEGE_ECOLI PSORT-B swissprot:YEGE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEGE_ECOLI PSORT2 swissprot:YEGE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEGE_ECOLI Pfam PF00563 http://pfam.xfam.org/family/PF00563 Pfam PF00990 http://pfam.xfam.org/family/PF00990 Pfam PF05231 http://pfam.xfam.org/family/PF05231 Pfam PF08447 http://pfam.xfam.org/family/PF08447 Pfam PF08448 http://pfam.xfam.org/family/PF08448 Pfam PF13426 http://pfam.xfam.org/family/PF13426 Phobius swissprot:YEGE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEGE_ECOLI PhylomeDB P38097 http://phylomedb.org/?seqid=P38097 ProteinModelPortal P38097 http://www.proteinmodelportal.org/query/uniprot/P38097 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18765794 http://www.ncbi.nlm.nih.gov/pubmed/18765794 PubMed 19332833 http://www.ncbi.nlm.nih.gov/pubmed/19332833 PubMed 20303158 http://www.ncbi.nlm.nih.gov/pubmed/20303158 PubMed 6094528 http://www.ncbi.nlm.nih.gov/pubmed/6094528 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416571 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416571 RefSeq WP_000043761 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000043761 SMART SM00052 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00052 SMART SM00086 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00086 SMART SM00091 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00091 SMART SM00267 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00267 SMR P38097 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P38097 STRING 511145.b2067 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2067&targetmode=cogs SUPFAM SSF141868 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF141868 SUPFAM SSF55073 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55073 SUPFAM SSF55785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55785 TIGRFAMs TIGR00229 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00229 TIGRFAMs TIGR00254 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00254 UniProtKB YEGE_ECOLI http://www.uniprot.org/uniprot/YEGE_ECOLI UniProtKB-AC P38097 http://www.uniprot.org/uniprot/P38097 charge swissprot:YEGE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEGE_ECOLI eggNOG COG2202 http://eggnogapi.embl.de/nog_data/html/tree/COG2202 eggNOG COG3447 http://eggnogapi.embl.de/nog_data/html/tree/COG3447 eggNOG ENOG4105BZU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZU epestfind swissprot:YEGE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEGE_ECOLI garnier swissprot:YEGE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEGE_ECOLI helixturnhelix swissprot:YEGE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEGE_ECOLI hmoment swissprot:YEGE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEGE_ECOLI iep swissprot:YEGE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEGE_ECOLI inforesidue swissprot:YEGE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEGE_ECOLI octanol swissprot:YEGE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEGE_ECOLI pepcoil swissprot:YEGE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEGE_ECOLI pepdigest swissprot:YEGE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEGE_ECOLI pepinfo swissprot:YEGE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEGE_ECOLI pepnet swissprot:YEGE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEGE_ECOLI pepstats swissprot:YEGE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEGE_ECOLI pepwheel swissprot:YEGE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEGE_ECOLI pepwindow swissprot:YEGE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEGE_ECOLI sigcleave swissprot:YEGE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEGE_ECOLI ## Database ID URL or Descriptions # BioGrid 4262669 9 # EcoGene EG11936 yjbR # InterPro IPR007351 YjbR # Organism YJBR_ECOLI Escherichia coli (strain K12) # PATRIC 32123659 VBIEscCol129921_4178 # PDB 2FKI NMR; -; A=1-118 # PIR H65213 H65213 # Pfam PF04237 YjbR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJBR_ECOLI Uncharacterized protein YjbR # RefSeq NP_418481 NC_000913.3 # RefSeq WP_000155657 NZ_LN832404.1 # eggNOG COG2315 LUCA # eggNOG ENOG4105MSB Bacteria BLAST swissprot:YJBR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJBR_ECOLI BioCyc ECOL316407:JW4018-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4018-MONOMER BioCyc EcoCyc:EG11936-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11936-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1111/j.1574-6968.1998.tb13343.x http://dx.doi.org/10.1111/j.1574-6968.1998.tb13343.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1880 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1880 EcoGene EG11936 http://www.ecogene.org/geneInfo.php?eg_id=EG11936 EnsemblBacteria AAC77027 http://www.ensemblgenomes.org/id/AAC77027 EnsemblBacteria AAC77027 http://www.ensemblgenomes.org/id/AAC77027 EnsemblBacteria BAE78059 http://www.ensemblgenomes.org/id/BAE78059 EnsemblBacteria BAE78059 http://www.ensemblgenomes.org/id/BAE78059 EnsemblBacteria BAE78059 http://www.ensemblgenomes.org/id/BAE78059 EnsemblBacteria b4057 http://www.ensemblgenomes.org/id/b4057 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 948560 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948560 HOGENOM HOG000013133 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000013133&db=HOGENOM6 InParanoid P0AF50 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AF50 IntAct P0AF50 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AF50* InterPro IPR007351 http://www.ebi.ac.uk/interpro/entry/IPR007351 KEGG_Gene ecj:JW4018 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4018 KEGG_Gene eco:b4057 http://www.genome.jp/dbget-bin/www_bget?eco:b4057 OMA KVGDVMF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KVGDVMF PDB 2FKI http://www.ebi.ac.uk/pdbe-srv/view/entry/2FKI PDBsum 2FKI http://www.ebi.ac.uk/pdbsum/2FKI PSORT swissprot:YJBR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJBR_ECOLI PSORT-B swissprot:YJBR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJBR_ECOLI PSORT2 swissprot:YJBR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJBR_ECOLI Pfam PF04237 http://pfam.xfam.org/family/PF04237 Phobius swissprot:YJBR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJBR_ECOLI PhylomeDB P0AF50 http://phylomedb.org/?seqid=P0AF50 ProteinModelPortal P0AF50 http://www.proteinmodelportal.org/query/uniprot/P0AF50 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9868784 http://www.ncbi.nlm.nih.gov/pubmed/9868784 RefSeq NP_418481 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418481 RefSeq WP_000155657 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000155657 SMR P0AF50 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AF50 STRING 511145.b4057 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4057&targetmode=cogs UniProtKB YJBR_ECOLI http://www.uniprot.org/uniprot/YJBR_ECOLI UniProtKB-AC P0AF50 http://www.uniprot.org/uniprot/P0AF50 charge swissprot:YJBR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJBR_ECOLI eggNOG COG2315 http://eggnogapi.embl.de/nog_data/html/tree/COG2315 eggNOG ENOG4105MSB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105MSB epestfind swissprot:YJBR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJBR_ECOLI garnier swissprot:YJBR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJBR_ECOLI helixturnhelix swissprot:YJBR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJBR_ECOLI hmoment swissprot:YJBR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJBR_ECOLI iep swissprot:YJBR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJBR_ECOLI inforesidue swissprot:YJBR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJBR_ECOLI octanol swissprot:YJBR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJBR_ECOLI pepcoil swissprot:YJBR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJBR_ECOLI pepdigest swissprot:YJBR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJBR_ECOLI pepinfo swissprot:YJBR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJBR_ECOLI pepnet swissprot:YJBR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJBR_ECOLI pepstats swissprot:YJBR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJBR_ECOLI pepwheel swissprot:YJBR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJBR_ECOLI pepwindow swissprot:YJBR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJBR_ECOLI sigcleave swissprot:YJBR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJBR_ECOLI ## Database ID URL or Descriptions # BioGrid 4259646 15 # EcoGene EG14205 yfgI # GO_process GO:0006974 cellular response to DNA damage stimulus; IMP:EcoCyc. # GOslim_process GO:0006950 response to stress # IntAct P76573 4 # InterPro IPR020231 Uncharacterised_YfgI # Organism YFGI_ECOLI Escherichia coli (strain K12) # PATRIC 32120403 VBIEscCol129921_2604 # PIR A65027 A65027 # ProDom PD095266 Uncharacterised_YfgI # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFGI_ECOLI Uncharacterized protein YfgI # RefSeq NP_417001 NC_000913.3 # RefSeq WP_000755173 NZ_LN832404.1 # eggNOG ENOG41066DY Bacteria # eggNOG ENOG4112BJD LUCA BLAST swissprot:YFGI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFGI_ECOLI BioCyc ECOL316407:JW2490-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2490-MONOMER BioCyc EcoCyc:G7317-MONOMER http://biocyc.org/getid?id=EcoCyc:G7317-MONOMER DIP DIP-12040N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12040N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3957 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3957 EcoGene EG14205 http://www.ecogene.org/geneInfo.php?eg_id=EG14205 EnsemblBacteria AAC75559 http://www.ensemblgenomes.org/id/AAC75559 EnsemblBacteria AAC75559 http://www.ensemblgenomes.org/id/AAC75559 EnsemblBacteria BAE76727 http://www.ensemblgenomes.org/id/BAE76727 EnsemblBacteria BAE76727 http://www.ensemblgenomes.org/id/BAE76727 EnsemblBacteria BAE76727 http://www.ensemblgenomes.org/id/BAE76727 EnsemblBacteria b2506 http://www.ensemblgenomes.org/id/b2506 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 945168 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945168 HOGENOM HOG000123074 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000123074&db=HOGENOM6 IntAct P76573 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76573* InterPro IPR020231 http://www.ebi.ac.uk/interpro/entry/IPR020231 KEGG_Gene ecj:JW2490 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2490 KEGG_Gene eco:b2506 http://www.genome.jp/dbget-bin/www_bget?eco:b2506 OMA QMELENM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QMELENM PSORT swissprot:YFGI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFGI_ECOLI PSORT-B swissprot:YFGI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFGI_ECOLI PSORT2 swissprot:YFGI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFGI_ECOLI Phobius swissprot:YFGI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFGI_ECOLI ProteinModelPortal P76573 http://www.proteinmodelportal.org/query/uniprot/P76573 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417001 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417001 RefSeq WP_000755173 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000755173 STRING 511145.b2506 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2506&targetmode=cogs UniProtKB YFGI_ECOLI http://www.uniprot.org/uniprot/YFGI_ECOLI UniProtKB-AC P76573 http://www.uniprot.org/uniprot/P76573 charge swissprot:YFGI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFGI_ECOLI eggNOG ENOG41066DY http://eggnogapi.embl.de/nog_data/html/tree/ENOG41066DY eggNOG ENOG4112BJD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4112BJD epestfind swissprot:YFGI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFGI_ECOLI garnier swissprot:YFGI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFGI_ECOLI helixturnhelix swissprot:YFGI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFGI_ECOLI hmoment swissprot:YFGI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFGI_ECOLI iep swissprot:YFGI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFGI_ECOLI inforesidue swissprot:YFGI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFGI_ECOLI octanol swissprot:YFGI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFGI_ECOLI pepcoil swissprot:YFGI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFGI_ECOLI pepdigest swissprot:YFGI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFGI_ECOLI pepinfo swissprot:YFGI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFGI_ECOLI pepnet swissprot:YFGI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFGI_ECOLI pepstats swissprot:YFGI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFGI_ECOLI pepwheel swissprot:YFGI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFGI_ECOLI pepwindow swissprot:YFGI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFGI_ECOLI sigcleave swissprot:YFGI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFGI_ECOLI ## Database ID URL or Descriptions # BioGrid 4259288 3 # CATALYTIC ACTIVITY MASY_ECOLI Acetyl-CoA + H(2)O + glyoxylate = (S)-malate + CoA. # CDD cd00727 malate_synt_A # EcoGene EG10023 aceB # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_function GO:0004474 malate synthase activity; IDA:EcoliWiki. # GO_process GO:0006097 glyoxylate cycle; IBA:GO_Central. # GO_process GO:0006099 tricarboxylic acid cycle; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0044281 small molecule metabolic process # IntAct P08997 6 # InterPro IPR001465 Malate_synthase # InterPro IPR006252 Malate_synthA # InterPro IPR011076 Malate_synth-like # InterPro IPR019830 Malate_synthase_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00620 Pyruvate metabolism # KEGG_Pathway ko00630 Glyoxylate and dicarboxylate metabolism # Organism MASY_ECOLI Escherichia coli (strain K12) # PATHWAY Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate step 2/2. # PATRIC 32123555 VBIEscCol129921_4126 # PDB 3CUZ X-ray; 1.04 A; A=2-533 # PDB 3CV1 X-ray; 1.68 A; A=2-533 # PDB 3CV2 X-ray; 1.40 A; A/B=2-533 # PIR A32649 SYECMA # PIRSF PIRSF001363 Malate_synth # PROSITE PS00510 MALATE_SYNTHASE # Pfam PF01274 Malate_synthase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MASY_ECOLI Malate synthase A # RefSeq NP_418438 NC_000913.3 # RefSeq WP_000138905 NZ_CP014272.1 # SIMILARITY Belongs to the malate synthase family. {ECO 0000305}. # SUBCELLULAR LOCATION MASY_ECOLI Cytoplasm. # SUPFAM SSF51645 SSF51645 # TIGRFAMs TIGR01344 malate_syn_A # UniPathway UPA00703 UER00720 # eggNOG COG2225 LUCA # eggNOG ENOG4107QP3 Bacteria BLAST swissprot:MASY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MASY_ECOLI BioCyc ECOL316407:JW3974-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3974-MONOMER BioCyc EcoCyc:MALATE-SYNTHASE http://biocyc.org/getid?id=EcoCyc:MALATE-SYNTHASE BioCyc MetaCyc:MALATE-SYNTHASE http://biocyc.org/getid?id=MetaCyc:MALATE-SYNTHASE COG COG2225 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2225 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/16.19.9342 http://dx.doi.org/10.1093/nar/16.19.9342 DOI 10.1093/nar/16.22.10924 http://dx.doi.org/10.1093/nar/16.22.10924 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.3.9 http://www.genome.jp/dbget-bin/www_bget?EC:2.3.3.9 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X12431 http://www.ebi.ac.uk/ena/data/view/X12431 ENZYME 2.3.3.9 http://enzyme.expasy.org/EC/2.3.3.9 EchoBASE EB0022 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0022 EcoGene EG10023 http://www.ecogene.org/geneInfo.php?eg_id=EG10023 EnsemblBacteria AAC76984 http://www.ensemblgenomes.org/id/AAC76984 EnsemblBacteria AAC76984 http://www.ensemblgenomes.org/id/AAC76984 EnsemblBacteria BAE78016 http://www.ensemblgenomes.org/id/BAE78016 EnsemblBacteria BAE78016 http://www.ensemblgenomes.org/id/BAE78016 EnsemblBacteria BAE78016 http://www.ensemblgenomes.org/id/BAE78016 EnsemblBacteria b4014 http://www.ensemblgenomes.org/id/b4014 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004474 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004474 GO_process GO:0006097 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006097 GO_process GO:0006099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006099 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 948512 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948512 HOGENOM HOG000238464 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000238464&db=HOGENOM6 InParanoid P08997 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P08997 IntAct P08997 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P08997* IntEnz 2.3.3.9 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.3.9 InterPro IPR001465 http://www.ebi.ac.uk/interpro/entry/IPR001465 InterPro IPR006252 http://www.ebi.ac.uk/interpro/entry/IPR006252 InterPro IPR011076 http://www.ebi.ac.uk/interpro/entry/IPR011076 InterPro IPR019830 http://www.ebi.ac.uk/interpro/entry/IPR019830 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3974 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3974 KEGG_Gene eco:b4014 http://www.genome.jp/dbget-bin/www_bget?eco:b4014 KEGG_Orthology KO:K01638 http://www.genome.jp/dbget-bin/www_bget?KO:K01638 KEGG_Pathway ko00620 http://www.genome.jp/kegg-bin/show_pathway?ko00620 KEGG_Pathway ko00630 http://www.genome.jp/kegg-bin/show_pathway?ko00630 KEGG_Reaction rn:R00472 http://www.genome.jp/dbget-bin/www_bget?rn:R00472 OMA CHKRGAP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CHKRGAP PDB 3CUZ http://www.ebi.ac.uk/pdbe-srv/view/entry/3CUZ PDB 3CV1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3CV1 PDB 3CV2 http://www.ebi.ac.uk/pdbe-srv/view/entry/3CV2 PDBsum 3CUZ http://www.ebi.ac.uk/pdbsum/3CUZ PDBsum 3CV1 http://www.ebi.ac.uk/pdbsum/3CV1 PDBsum 3CV2 http://www.ebi.ac.uk/pdbsum/3CV2 PROSITE PS00510 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00510 PSORT swissprot:MASY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MASY_ECOLI PSORT-B swissprot:MASY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MASY_ECOLI PSORT2 swissprot:MASY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MASY_ECOLI Pfam PF01274 http://pfam.xfam.org/family/PF01274 Phobius swissprot:MASY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MASY_ECOLI PhylomeDB P08997 http://phylomedb.org/?seqid=P08997 ProteinModelPortal P08997 http://www.proteinmodelportal.org/query/uniprot/P08997 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3050899 http://www.ncbi.nlm.nih.gov/pubmed/3050899 PubMed 3060852 http://www.ncbi.nlm.nih.gov/pubmed/3060852 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418438 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418438 RefSeq WP_000138905 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000138905 SMR P08997 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P08997 STRING 511145.b4014 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4014&targetmode=cogs STRING COG2225 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2225&targetmode=cogs SUPFAM SSF51645 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51645 TIGRFAMs TIGR01344 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01344 UniProtKB MASY_ECOLI http://www.uniprot.org/uniprot/MASY_ECOLI UniProtKB-AC P08997 http://www.uniprot.org/uniprot/P08997 charge swissprot:MASY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MASY_ECOLI eggNOG COG2225 http://eggnogapi.embl.de/nog_data/html/tree/COG2225 eggNOG ENOG4107QP3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QP3 epestfind swissprot:MASY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MASY_ECOLI garnier swissprot:MASY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MASY_ECOLI helixturnhelix swissprot:MASY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MASY_ECOLI hmoment swissprot:MASY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MASY_ECOLI iep swissprot:MASY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MASY_ECOLI inforesidue swissprot:MASY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MASY_ECOLI octanol swissprot:MASY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MASY_ECOLI pepcoil swissprot:MASY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MASY_ECOLI pepdigest swissprot:MASY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MASY_ECOLI pepinfo swissprot:MASY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MASY_ECOLI pepnet swissprot:MASY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MASY_ECOLI pepstats swissprot:MASY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MASY_ECOLI pepwheel swissprot:MASY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MASY_ECOLI pepwindow swissprot:MASY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MASY_ECOLI sigcleave swissprot:MASY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MASY_ECOLI ## Database ID URL or Descriptions # AltName Alpha-aspartyl dipeptidase {ECO:0000255|HAMAP-Rule MF_00510} # AltName Asp-specific dipeptidase {ECO:0000255|HAMAP-Rule MF_00510} # AltName Dipeptidase E {ECO:0000255|HAMAP-Rule MF_00510} # BioGrid 4262655 8 # CATALYTIC ACTIVITY Dipeptidase E catalyzes the hydrolysis of dipeptides Asp-|-Xaa. It does not act on peptides with N-terminal Glu, Asn or Gln, nor does it cleave isoaspartyl peptides. {ECO:0000255|HAMAP-Rule MF_00510}. # EcoGene EG11920 pepE # FUNCTION PEPE_ECOLI Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids. {ECO 0000255|HAMAP- Rule MF_00510}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0008233 peptidase activity; IDA:EcoCyc. # GO_function GO:0008236 serine-type peptidase activity; IEA:UniProtKB-KW. # GO_function GO:0016805 dipeptidase activity; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0008233 peptidase activity # Gene3D 3.40.50.880 -; 1. # HAMAP MF_00510 Peptidase_E # IntAct P0A7C6 4 # InterPro IPR005320 Peptidase_S51 # InterPro IPR023172 Peptidase_S51_dipeptidase-E # InterPro IPR029062 Class_I_gatase-like # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # Organism PEPE_ECOLI Escherichia coli (strain K12) # PATRIC 32123571 VBIEscCol129921_4134 # PIR D65209 D65209 # Pfam PF03575 Peptidase_S51 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Peptidase E {ECO:0000255|HAMAP-Rule MF_00510} # RefSeq NP_418445 NC_000913.3 # RefSeq WP_000421763 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase S51 family. {ECO:0000255|HAMAP-Rule MF_00510}. # SUBCELLULAR LOCATION PEPE_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00510}. # SUPFAM SSF52317 SSF52317 # eggNOG COG3340 LUCA # eggNOG ENOG4105EQ6 Bacteria BLAST swissprot:PEPE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PEPE_ECOLI BioCyc ECOL316407:JW3981-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3981-MONOMER BioCyc EcoCyc:EG11920-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11920-MONOMER BioCyc MetaCyc:EG11920-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11920-MONOMER COG COG3340 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3340 DIP DIP-48072N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48072N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.13.21 {ECO:0000255|HAMAP-Rule:MF_00510} http://www.genome.jp/dbget-bin/www_bget?EC:3.4.13.21 {ECO:0000255|HAMAP-Rule:MF_00510} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.4.13.21 {ECO:0000255|HAMAP-Rule:MF_00510} http://enzyme.expasy.org/EC/3.4.13.21 {ECO:0000255|HAMAP-Rule:MF_00510} EchoBASE EB1864 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1864 EcoGene EG11920 http://www.ecogene.org/geneInfo.php?eg_id=EG11920 EnsemblBacteria AAC76991 http://www.ensemblgenomes.org/id/AAC76991 EnsemblBacteria AAC76991 http://www.ensemblgenomes.org/id/AAC76991 EnsemblBacteria BAE78023 http://www.ensemblgenomes.org/id/BAE78023 EnsemblBacteria BAE78023 http://www.ensemblgenomes.org/id/BAE78023 EnsemblBacteria BAE78023 http://www.ensemblgenomes.org/id/BAE78023 EnsemblBacteria b4021 http://www.ensemblgenomes.org/id/b4021 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GO_function GO:0008236 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008236 GO_function GO:0016805 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016805 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 Gene3D 3.40.50.880 http://www.cathdb.info/version/latest/superfamily/3.40.50.880 GeneID 948520 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948520 HAMAP MF_00510 http://hamap.expasy.org/unirule/MF_00510 HOGENOM HOG000281834 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000281834&db=HOGENOM6 InParanoid P0A7C6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7C6 IntAct P0A7C6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7C6* IntEnz 3.4.13.21 {ECO:0000255|HAMAP-Rule:MF_00510} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.13.21 {ECO:0000255|HAMAP-Rule:MF_00510} InterPro IPR005320 http://www.ebi.ac.uk/interpro/entry/IPR005320 InterPro IPR023172 http://www.ebi.ac.uk/interpro/entry/IPR023172 InterPro IPR029062 http://www.ebi.ac.uk/interpro/entry/IPR029062 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW3981 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3981 KEGG_Gene eco:b4021 http://www.genome.jp/dbget-bin/www_bget?eco:b4021 KEGG_Orthology KO:K05995 http://www.genome.jp/dbget-bin/www_bget?KO:K05995 MINT MINT-1236370 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1236370 OMA KYTATVR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KYTATVR PSORT swissprot:PEPE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PEPE_ECOLI PSORT-B swissprot:PEPE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PEPE_ECOLI PSORT2 swissprot:PEPE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PEPE_ECOLI Pfam PF03575 http://pfam.xfam.org/family/PF03575 Phobius swissprot:PEPE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PEPE_ECOLI PhylomeDB P0A7C6 http://phylomedb.org/?seqid=P0A7C6 ProteinModelPortal P0A7C6 http://www.proteinmodelportal.org/query/uniprot/P0A7C6 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418445 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418445 RefSeq WP_000421763 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000421763 SMR P0A7C6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7C6 STRING 511145.b4021 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4021&targetmode=cogs STRING COG3340 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3340&targetmode=cogs SUPFAM SSF52317 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52317 UniProtKB PEPE_ECOLI http://www.uniprot.org/uniprot/PEPE_ECOLI UniProtKB-AC P0A7C6 http://www.uniprot.org/uniprot/P0A7C6 charge swissprot:PEPE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PEPE_ECOLI eggNOG COG3340 http://eggnogapi.embl.de/nog_data/html/tree/COG3340 eggNOG ENOG4105EQ6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EQ6 epestfind swissprot:PEPE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PEPE_ECOLI garnier swissprot:PEPE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PEPE_ECOLI helixturnhelix swissprot:PEPE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PEPE_ECOLI hmoment swissprot:PEPE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PEPE_ECOLI iep swissprot:PEPE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PEPE_ECOLI inforesidue swissprot:PEPE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PEPE_ECOLI octanol swissprot:PEPE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PEPE_ECOLI pepcoil swissprot:PEPE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PEPE_ECOLI pepdigest swissprot:PEPE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PEPE_ECOLI pepinfo swissprot:PEPE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PEPE_ECOLI pepnet swissprot:PEPE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PEPE_ECOLI pepstats swissprot:PEPE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PEPE_ECOLI pepwheel swissprot:PEPE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PEPE_ECOLI pepwindow swissprot:PEPE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PEPE_ECOLI sigcleave swissprot:PEPE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PEPE_ECOLI ## Database ID URL or Descriptions # BioGrid 4263376 294 # CATALYTIC ACTIVITY CFA_ECOLI S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid. # ENZYME REGULATION Inhibited by sinefungin, A9145C and S-adenosyl- L-homocysteine. {ECO:0000269|PubMed 1445840}. # EcoGene EG11531 cfa # FUNCTION CFA_ECOLI Transfers a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge. {ECO 0000250}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008825 cyclopropane-fatty-acyl-phospholipid synthase activity; IDA:EcoCyc. # GO_process GO:0006633 fatty acid biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0030258 lipid modification; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.150 -; 1. # IntAct P0A9H7 2 # InterPro IPR003333 Mycolic_cyclopropane_synthase # InterPro IPR029063 SAM-dependent_MTases # KEGG_Brite ko01000 Enzymes # Organism CFA_ECOLI Escherichia coli (strain K12) # PATHWAY CFA_ECOLI Lipid metabolism; fatty acid biosynthesis. # PATRIC 32118628 VBIEscCol129921_1734 # PIR A44292 A44292 # PIRSF PIRSF003085 CMAS # Pfam PF02353 CMAS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CFA_ECOLI Cyclopropane-fatty-acyl-phospholipid synthase # RefSeq NP_416178 NC_000913.3 # RefSeq WP_000098896 NZ_LN832404.1 # SIMILARITY Belongs to the CFA/CMAS family. {ECO 0000305}. # SUBCELLULAR LOCATION CFA_ECOLI Cytoplasm. # SUPFAM SSF53335 SSF53335 # eggNOG COG2230 LUCA # eggNOG ENOG4105CV9 Bacteria BLAST swissprot:CFA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CFA_ECOLI BioCyc ECOL316407:JW1653-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1653-MONOMER BioCyc EcoCyc:CFA-MONOMER http://biocyc.org/getid?id=EcoCyc:CFA-MONOMER BioCyc MetaCyc:CFA-MONOMER http://biocyc.org/getid?id=MetaCyc:CFA-MONOMER COG COG2230 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2230 DIP DIP-48026N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48026N DOI 10.1021/bi00160a011 http://dx.doi.org/10.1021/bi00160a011 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.1.79 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.79 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M98330 http://www.ebi.ac.uk/ena/data/view/M98330 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X69109 http://www.ebi.ac.uk/ena/data/view/X69109 ENZYME 2.1.1.79 http://enzyme.expasy.org/EC/2.1.1.79 EchoBASE EB1493 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1493 EcoGene EG11531 http://www.ecogene.org/geneInfo.php?eg_id=EG11531 EnsemblBacteria AAC74733 http://www.ensemblgenomes.org/id/AAC74733 EnsemblBacteria AAC74733 http://www.ensemblgenomes.org/id/AAC74733 EnsemblBacteria BAA15428 http://www.ensemblgenomes.org/id/BAA15428 EnsemblBacteria BAA15428 http://www.ensemblgenomes.org/id/BAA15428 EnsemblBacteria BAA15428 http://www.ensemblgenomes.org/id/BAA15428 EnsemblBacteria b1661 http://www.ensemblgenomes.org/id/b1661 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008825 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008825 GO_process GO:0006633 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006633 GO_process GO:0030258 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030258 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 GeneID 944811 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944811 HOGENOM HOG000245194 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000245194&db=HOGENOM6 InParanoid P0A9H7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9H7 IntAct P0A9H7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9H7* IntEnz 2.1.1.79 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.79 InterPro IPR003333 http://www.ebi.ac.uk/interpro/entry/IPR003333 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1653 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1653 KEGG_Gene eco:b1661 http://www.genome.jp/dbget-bin/www_bget?eco:b1661 KEGG_Orthology KO:K00574 http://www.genome.jp/dbget-bin/www_bget?KO:K00574 MINT MINT-1312967 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1312967 OMA AKLDMIC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AKLDMIC PSORT swissprot:CFA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CFA_ECOLI PSORT-B swissprot:CFA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CFA_ECOLI PSORT2 swissprot:CFA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CFA_ECOLI Pfam PF02353 http://pfam.xfam.org/family/PF02353 Phobius swissprot:CFA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CFA_ECOLI PhylomeDB P0A9H7 http://phylomedb.org/?seqid=P0A9H7 ProteinModelPortal P0A9H7 http://www.proteinmodelportal.org/query/uniprot/P0A9H7 PubMed 1445840 http://www.ncbi.nlm.nih.gov/pubmed/1445840 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416178 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416178 RefSeq WP_000098896 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000098896 SMR P0A9H7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9H7 STRING 511145.b1661 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1661&targetmode=cogs STRING COG2230 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2230&targetmode=cogs SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 UniProtKB CFA_ECOLI http://www.uniprot.org/uniprot/CFA_ECOLI UniProtKB-AC P0A9H7 http://www.uniprot.org/uniprot/P0A9H7 charge swissprot:CFA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CFA_ECOLI eggNOG COG2230 http://eggnogapi.embl.de/nog_data/html/tree/COG2230 eggNOG ENOG4105CV9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CV9 epestfind swissprot:CFA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CFA_ECOLI garnier swissprot:CFA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CFA_ECOLI helixturnhelix swissprot:CFA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CFA_ECOLI hmoment swissprot:CFA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CFA_ECOLI iep swissprot:CFA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CFA_ECOLI inforesidue swissprot:CFA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CFA_ECOLI octanol swissprot:CFA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CFA_ECOLI pepcoil swissprot:CFA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CFA_ECOLI pepdigest swissprot:CFA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CFA_ECOLI pepinfo swissprot:CFA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CFA_ECOLI pepnet swissprot:CFA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CFA_ECOLI pepstats swissprot:CFA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CFA_ECOLI pepwheel swissprot:CFA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CFA_ECOLI pepwindow swissprot:CFA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CFA_ECOLI sigcleave swissprot:CFA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CFA_ECOLI ## Database ID URL or Descriptions # AltName MAZF_ECOLI Toxin MazF # AltName mRNA interferase MazF {ECO:0000303|PubMed 15537630} # BIOTECHNOLOGY Can be used to produce large quantities of a single protein if the gene coding for the protein does not contain any ACA codons. Up to 90% of expressed bacterial cellular protein can be the target, which can be produced for up to 4 days. The system also works in eukaryotic cells. {ECO:0000269|PubMed 15837428}. # BioGrid 4262300 13 # CAUTION Strain K12 / MG1655 is deficient in both production and response to EDF, unlike strains K12 / MC4100, K12 / W3110 and K12 / K38, all of which make and respond to EDF. {ECO:0000269|PubMed 18310334}. # DISRUPTION PHENOTYPE MAZF_ECOLI Decreased sensitivity to dramatic intracellular increases of ppGpp. Cells missing mazE-mazF survive high temperature, various DNA-damaging agents and H(2)O(2) exposure better than wild-type cells. Cells missing mazE-mazF produce more P1 phage than wild-type cells, while introduction of lysogens into a growing non-lysogenic disruption culture is lethal (PubMed 15316771). Cells missing mazE-mazF show reduced biofilm formation, and survive antibiotic treatment in log phase better than wild-type cells (PubMed 11222603, PubMed 19707553). However lag phase cells disrupted only for mazF had a lower survival rate than wild-type cells (PubMed 24375411). Cells missing mazE-mazF survive hydroxyurea treatment better than wild-type; further disruption of relE-relB and tonB yields even better survival (PubMed 20005847). Cells missing mazE-mazF undergo an apoptotic- like death (ALD) upon DNA damage characterized by membrane depolarization and DNA fragmentation; further disruption of recA prevents membrane depolarization (PubMed 22412352). Unlike the single srkA disruption mutant, a triple srkA-mazE-mazF disruption mutant shows no hyperlethality in the presence of nalidixic acid or UV light, suggesting SrkA has a negative effect on MazF (PubMed 23416055). {ECO 0000269|PubMed 11222603, ECO 0000269|PubMed 12972253, ECO 0000269|PubMed 15150257, ECO 0000269|PubMed 15316771, ECO 0000269|PubMed 19707553, ECO 0000269|PubMed 20005847, ECO 0000269|PubMed 22412352, ECO 0000269|PubMed 23416055, ECO 0000269|PubMed 24375411, ECO 0000269|PubMed 8650219}. # DOMAIN MAZF_ECOLI Loop 1 (residues 17-28) effects catalytic activity while recognition of the ACA cleavage site is influenced by loop 2 (residues 53-61). Alterations of loop 2 generate new cleavage sites in addition to retaining the original cleavage site. {ECO 0000305|PubMed 23280569}. # ENZYME REGULATION MAZF_ECOLI Inhibited by Mg(2+) (PubMed 15537630). Stimulated in vitro in a concentration-dependent fashion by EDF, which is able to overcome inhibition by cognate antitoxin MazE (PubMed 21419338). The TA module is antagonized by stress response kinase SrkA, but probably not by phosphorylation of MazF (PubMed 23416055). {ECO 0000269|PubMed 15537630, ECO 0000269|PubMed 21419338, ECO 0000269|PubMed 23416055}. # EcoGene EG11249 mazF # FUNCTION MAZF_ECOLI Might also serve to protect cells against bacteriophage; in the presence of MazE-MazF fewer P1 phage are produced than in a disrupted strain. For strain K38 most wild-type cells are killed but not by phage lysis; it was suggested that MazE-MazF causes P1 phage exclusion from the bacterial population. This phenomenon is strain dependent. {ECO 0000269|PubMed 15316771}. # FUNCTION MAZF_ECOLI The physiological role of this TA module is debated. Programmed cell death (PCD) occurs when cells are at high density and depends on the presence of MazE-MazF and a quorum sensing pentapeptide, the extracellular death factor (EDF) with sequence Asn-Asn-Trp-Asn-Asn (NNWNN), probably produced from the zwf gene product glucose-6-phosphate 1-dehydrogenase (PubMed 17962566, PubMed 18310334). Cell death governed by the MazE-MazF and DinJ- YafQ TA modules seems to play a role in biofilm formation, while MazE-MazF is also implicated in cell death in liquid media (PubMed 19707553). Implicated in hydroxy radical-mediated cell death induced by hydroxyurea treatment (PubMed 20005847, PubMed 23416055). In conjunction with EDF prevents apoptotic-like death (ALD) in the presence of DNA damaging agents, probably by reducing recA mRNA levels in a non-endonuclease-mediated manner (PubMed 22412352). Other studies (in strains BW25113 and MC4100, the latter makes EDF) demonstrate MazF does not cause PCD but instead bacteriostasis and possibly a dormant state as well as persister cell generation (PubMed 24375411). {ECO 0000269|PubMed 17962566, ECO 0000269|PubMed 18310334, ECO 0000269|PubMed 19707553, ECO 0000269|PubMed 20005847, ECO 0000269|PubMed 21419338, ECO 0000269|PubMed 22412352, ECO 0000269|PubMed 23416055, ECO 0000269|PubMed 24375411, ECO 0000269|PubMed 8650219}. # FUNCTION MAZF_ECOLI Toxic component of a type II toxin-antitoxin (TA) module. A sequence-specific endoribonuclease it inhibits protein synthesis by cleaving mRNA and inducing bacterial stasis. It is stable, single-strand specific with mRNA cleavage independent of the ribosome, although translation enhances cleavage for some mRNAs (PubMed 18854355). Cleavage occurs at the 5'-end of ACA sequences, yielding a 2',3'-cyclic phosphate and a free 5'-OH, although cleavage can also occur on the 3'-end of the first A (PubMed 15537630, PubMed 23280569). Digests 16S rRNA in vivo 43 nts upstream of the C-terminus; this removes the anti-Shine- Dalgarno sequence forming a mixed population of wild-type and "stress ribosomes". Stress ribosomes do not translate leader- containing mRNA but are proficient in translation of leaderless mRNA, which alters the protein expression profile of the cell; MazF produces some leaderless mRNA (PubMed 21944167). The toxic endoribonuclease activity is inhibited by its labile cognate antitoxin MazE. Toxicity results when the levels of MazE decrease in the cell, leading to mRNA degradation. This effect can be rescued by expression of MazE, but after 6 hours in rich medium overexpression of MazF leads to programmed cell death (PubMed 8650219, PubMed 11222603). MazF-mediated cell death occurs following a number of stress conditions in a relA-dependent fashion and only when cells are in log phase; sigma factor S (rpoS) protects stationary phase cells from MazF-killing (PubMed 15150257, PubMed 19251848). Cell growth and viability are not affected when MazF and MazE are coexpressed. Both MazE and MazE-MazF bind to the promoter region of the mazE-mazF operon to inhibit their own transcription. MazE has higher affinity for promoter DNA in the presence of MazF (PubMed 25564525). Cross-talk can occur between different TA modules. Ectopic expression of this toxin induces transcription of the relBEF TA module operon with specific cleavage of the mRNA produced (PubMed 23432955). {ECO 0000269|PubMed 11071896, ECO 0000269|PubMed 11222603, ECO 0000269|PubMed 15150257, ECO 0000269|PubMed 15537630, ECO 0000269|PubMed 18854355, ECO 0000269|PubMed 19251848, ECO 0000269|PubMed 21944167, ECO 0000269|PubMed 23280569, ECO 0000269|PubMed 23432955, ECO 0000269|PubMed 25564525, ECO 0000269|PubMed 8650219}. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003723 RNA binding; IEA:UniProtKB-KW. # GO_function GO:0004521 endoribonuclease activity; IDA:UniProtKB. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006402 mRNA catabolic process; IDA:UniProtKB. # GO_process GO:0006417 regulation of translation; IEA:UniProtKB-KW. # GO_process GO:0009372 quorum sensing; IEA:UniProtKB-KW. # GO_process GO:0016075 rRNA catabolic process; IDA:UniProtKB. # GO_process GO:0030308 negative regulation of cell growth; IMP:UniProtKB. # GO_process GO:0051607 defense response to virus; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0004518 nuclease activity # GOslim_process GO:0002376 immune system process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # GOslim_process GO:0042592 homeostatic process # GOslim_process GO:0044403 symbiosis, encompassing mutualism through parasitism # Gene3D 2.30.30.110 -; 1. # INDUCTION MAZF_ECOLI Expressed in exponentially growing cells. Induction has been reported to occur after amino acid starvation in a ppGpp- independent fashion and to be Lon protease-dependent (PubMed 12972253), but also to not occur after amino acid starvation and to be regulated by ppGpp (PubMed 8650219). Also induced in M9 minimal medium and by chloramphenicol treatment (PubMed 21944167). MazE alone and in combination with MazF, represses transcription of the mazE-mazF operon. Fis activates transcription. Part of the relA-mazE-mazF-mazG operon, there is also a second mazE-mazF specific promoter which is negatively autoregulated (PubMed 2844820, PubMed 8650219). Operon induced by ectopic expression of toxin RelE; operon induction by amino acid starvation requires the relBEF operon (PubMed 23432955). {ECO 0000269|PubMed 11071896, ECO 0000269|PubMed 12972253, ECO 0000269|PubMed 16390452, ECO 0000269|PubMed 21944167, ECO 0000269|PubMed 23432955, ECO 0000269|PubMed 2844820, ECO 0000269|PubMed 8650219}. # IntAct P0AE70 2 # InterPro IPR003477 PemK-like # InterPro IPR011067 Plasmid_toxin/cell-grow_inhib # KEGG_Brite ko01000 Enzymes # Organism MAZF_ECOLI Escherichia coli (strain K12) # PATRIC 32120980 VBIEscCol129921_2882 # PDB 1UB4 X-ray; 1.70 A; A/B=2-111 # PDB 3NFC X-ray; 2.00 A; A/B/C/D/E/F=1-111 # PDB 5CK9 X-ray; 1.90 A; A/B=1-111 # PDB 5CKB X-ray; 2.80 A; A/B=1-111 # PDB 5CKD X-ray; 1.70 A; A/B=1-111 # PDB 5CKE X-ray; 2.31 A; A/B=1-111 # PDB 5CKF X-ray; 2.80 A; A/B=1-111 # PDB 5CKH X-ray; 2.45 A; A/B=1-111 # PDB 5CO7 X-ray; 3.49 A; A/B/C/D/E/F=1-111 # PDB 5CQX X-ray; 1.63 A; A/B=1-111 # PDB 5CQY X-ray; 2.48 A; A/B=1-111 # PDB 5CR2 X-ray; 2.90 A; A/B/C=1-111 # PIR B49339 B49339 # Pfam PF02452 PemK_toxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MAZF_ECOLI Endoribonuclease MazF # RefSeq NP_417262 NC_000913.3 # RefSeq WP_000254738 NZ_LN832404.1 # SIMILARITY Belongs to the PemK/MazF family. {ECO 0000305}. # SUBUNIT MAZF_ECOLI Probably a dimer. Forms a heterohexamer composed of alternating toxin and antitoxin homodimers MazF(2)-MazE(2)- MazF(2). The binding site of MazE and ssRNA or ssDNA are largely overlapping; the presence of only 1 MazE molecule inhibits mRNA endoribonuclease activity. Binds to EDF but not a mutated EDF (NNGNN) (PubMed 21419338). {ECO 0000269|PubMed 11071896, ECO 0000269|PubMed 12718874, ECO 0000269|PubMed 21419338, ECO 0000269|PubMed 25564525, ECO 0000269|PubMed 8650219}. # SUPFAM SSF50118 SSF50118 # eggNOG COG2337 LUCA # eggNOG ENOG4105MZG Bacteria BLAST swissprot:MAZF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MAZF_ECOLI BioCyc ECOL316407:JW2753-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2753-MONOMER BioCyc EcoCyc:EG11249-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11249-MONOMER BioCyc MetaCyc:EG11249-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11249-MONOMER COG COG2337 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2337 DOI 10.1002/prot.24246 http://dx.doi.org/10.1002/prot.24246 DOI 10.1007/s00438-004-1048-y http://dx.doi.org/10.1007/s00438-004-1048-y DOI 10.1016/S0022-2836(03)00922-7 http://dx.doi.org/10.1016/S0022-2836(03)00922-7 DOI 10.1016/S0079-6603(08)00812-X http://dx.doi.org/10.1016/S0079-6603(08)00812-X DOI 10.1016/S1097-2765(03)00097-2 http://dx.doi.org/10.1016/S1097-2765(03)00097-2 DOI 10.1016/j.cell.2011.07.047 http://dx.doi.org/10.1016/j.cell.2011.07.047 DOI 10.1016/j.celrep.2013.01.026 http://dx.doi.org/10.1016/j.celrep.2013.01.026 DOI 10.1016/j.jmb.2005.12.035 http://dx.doi.org/10.1016/j.jmb.2005.12.035 DOI 10.1016/j.molcel.2005.03.011 http://dx.doi.org/10.1016/j.molcel.2005.03.011 DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1016/j.molcel.2011.02.023 http://dx.doi.org/10.1016/j.molcel.2011.02.023 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2002.03027.x http://dx.doi.org/10.1046/j.1365-2958.2002.03027.x DOI 10.1073/pnas.93.12.6059 http://dx.doi.org/10.1073/pnas.93.12.6059 DOI 10.1074/jbc.M008832200 http://dx.doi.org/10.1074/jbc.M008832200 DOI 10.1074/jbc.M113.510511 http://dx.doi.org/10.1074/jbc.M113.510511 DOI 10.1074/jbc.M411811200 http://dx.doi.org/10.1074/jbc.M411811200 DOI 10.1093/nar/gkn667 http://dx.doi.org/10.1093/nar/gkn667 DOI 10.1093/nar/gku1352 http://dx.doi.org/10.1093/nar/gku1352 DOI 10.1111/j.1365-2958.2005.04956.x http://dx.doi.org/10.1111/j.1365-2958.2005.04956.x DOI 10.1126/science.1147248 http://dx.doi.org/10.1126/science.1147248 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00011-09 http://dx.doi.org/10.1128/JB.00011-09 DOI 10.1128/JB.01918-07 http://dx.doi.org/10.1128/JB.01918-07 DOI 10.1128/JB.183.6.2041-2045.2001 http://dx.doi.org/10.1128/JB.183.6.2041-2045.2001 DOI 10.1128/JB.186.11.3663-3669.2004 http://dx.doi.org/10.1128/JB.186.11.3663-3669.2004 DOI 10.1128/JB.186.24.8295-8300.2004 http://dx.doi.org/10.1128/JB.186.24.8295-8300.2004 DOI 10.1186/1471-2180-13-45 http://dx.doi.org/10.1186/1471-2180-13-45 DOI 10.1371/journal.pbio.1001281 http://dx.doi.org/10.1371/journal.pbio.1001281 DOI 10.1371/journal.pone.0006785 http://dx.doi.org/10.1371/journal.pone.0006785 DisProt DP00299 http://www.disprot.org/protein.php?id=DP00299 EC_number EC:3.1.27.- {ECO:0000269|PubMed:15537630} http://www.genome.jp/dbget-bin/www_bget?EC:3.1.27.- {ECO:0000269|PubMed:15537630} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D16450 http://www.ebi.ac.uk/ena/data/view/D16450 EMBL J04039 http://www.ebi.ac.uk/ena/data/view/J04039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29580 http://www.ebi.ac.uk/ena/data/view/U29580 ENZYME 3.1.27.- {ECO:0000269|PubMed:15537630} http://enzyme.expasy.org/EC/3.1.27.- {ECO:0000269|PubMed:15537630} EchoBASE EB1229 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1229 EcoGene EG11249 http://www.ecogene.org/geneInfo.php?eg_id=EG11249 EnsemblBacteria AAC75824 http://www.ensemblgenomes.org/id/AAC75824 EnsemblBacteria AAC75824 http://www.ensemblgenomes.org/id/AAC75824 EnsemblBacteria BAE76856 http://www.ensemblgenomes.org/id/BAE76856 EnsemblBacteria BAE76856 http://www.ensemblgenomes.org/id/BAE76856 EnsemblBacteria BAE76856 http://www.ensemblgenomes.org/id/BAE76856 EnsemblBacteria b2782 http://www.ensemblgenomes.org/id/b2782 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0004521 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004521 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0006402 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006402 GO_process GO:0006417 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006417 GO_process GO:0009372 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009372 GO_process GO:0016075 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016075 GO_process GO:0030308 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030308 GO_process GO:0051607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051607 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_process GO:0002376 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GOslim_process GO:0044403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403 Gene3D 2.30.30.110 http://www.cathdb.info/version/latest/superfamily/2.30.30.110 GeneID 947252 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947252 HOGENOM HOG000290185 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000290185&db=HOGENOM6 InParanoid P0AE70 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AE70 IntAct P0AE70 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AE70* IntEnz 3.1.27.- {ECO:0000269|PubMed:15537630} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.27.- {ECO:0000269|PubMed:15537630} InterPro IPR003477 http://www.ebi.ac.uk/interpro/entry/IPR003477 InterPro IPR011067 http://www.ebi.ac.uk/interpro/entry/IPR011067 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2753 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2753 KEGG_Gene eco:b2782 http://www.genome.jp/dbget-bin/www_bget?eco:b2782 KEGG_Orthology KO:K07171 http://www.genome.jp/dbget-bin/www_bget?KO:K07171 OMA QAGREQS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QAGREQS PDB 1UB4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1UB4 PDB 3NFC http://www.ebi.ac.uk/pdbe-srv/view/entry/3NFC PDB 5CK9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5CK9 PDB 5CKB http://www.ebi.ac.uk/pdbe-srv/view/entry/5CKB PDB 5CKD http://www.ebi.ac.uk/pdbe-srv/view/entry/5CKD PDB 5CKE http://www.ebi.ac.uk/pdbe-srv/view/entry/5CKE PDB 5CKF http://www.ebi.ac.uk/pdbe-srv/view/entry/5CKF PDB 5CKH http://www.ebi.ac.uk/pdbe-srv/view/entry/5CKH PDB 5CO7 http://www.ebi.ac.uk/pdbe-srv/view/entry/5CO7 PDB 5CQX http://www.ebi.ac.uk/pdbe-srv/view/entry/5CQX PDB 5CQY http://www.ebi.ac.uk/pdbe-srv/view/entry/5CQY PDB 5CR2 http://www.ebi.ac.uk/pdbe-srv/view/entry/5CR2 PDBsum 1UB4 http://www.ebi.ac.uk/pdbsum/1UB4 PDBsum 3NFC http://www.ebi.ac.uk/pdbsum/3NFC PDBsum 5CK9 http://www.ebi.ac.uk/pdbsum/5CK9 PDBsum 5CKB http://www.ebi.ac.uk/pdbsum/5CKB PDBsum 5CKD http://www.ebi.ac.uk/pdbsum/5CKD PDBsum 5CKE http://www.ebi.ac.uk/pdbsum/5CKE PDBsum 5CKF http://www.ebi.ac.uk/pdbsum/5CKF PDBsum 5CKH http://www.ebi.ac.uk/pdbsum/5CKH PDBsum 5CO7 http://www.ebi.ac.uk/pdbsum/5CO7 PDBsum 5CQX http://www.ebi.ac.uk/pdbsum/5CQX PDBsum 5CQY http://www.ebi.ac.uk/pdbsum/5CQY PDBsum 5CR2 http://www.ebi.ac.uk/pdbsum/5CR2 PSORT swissprot:MAZF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MAZF_ECOLI PSORT-B swissprot:MAZF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MAZF_ECOLI PSORT2 swissprot:MAZF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MAZF_ECOLI Pfam PF02452 http://pfam.xfam.org/family/PF02452 Phobius swissprot:MAZF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MAZF_ECOLI PhylomeDB P0AE70 http://phylomedb.org/?seqid=P0AE70 ProteinModelPortal P0AE70 http://www.proteinmodelportal.org/query/uniprot/P0AE70 PubMed 11071896 http://www.ncbi.nlm.nih.gov/pubmed/11071896 PubMed 11222603 http://www.ncbi.nlm.nih.gov/pubmed/11222603 PubMed 12123459 http://www.ncbi.nlm.nih.gov/pubmed/12123459 PubMed 12718874 http://www.ncbi.nlm.nih.gov/pubmed/12718874 PubMed 12972253 http://www.ncbi.nlm.nih.gov/pubmed/12972253 PubMed 15150257 http://www.ncbi.nlm.nih.gov/pubmed/15150257 PubMed 15316771 http://www.ncbi.nlm.nih.gov/pubmed/15316771 PubMed 15537630 http://www.ncbi.nlm.nih.gov/pubmed/15537630 PubMed 15576778 http://www.ncbi.nlm.nih.gov/pubmed/15576778 PubMed 15837428 http://www.ncbi.nlm.nih.gov/pubmed/15837428 PubMed 16390452 http://www.ncbi.nlm.nih.gov/pubmed/16390452 PubMed 16413577 http://www.ncbi.nlm.nih.gov/pubmed/16413577 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17962566 http://www.ncbi.nlm.nih.gov/pubmed/17962566 PubMed 18310334 http://www.ncbi.nlm.nih.gov/pubmed/18310334 PubMed 18854355 http://www.ncbi.nlm.nih.gov/pubmed/18854355 PubMed 19215780 http://www.ncbi.nlm.nih.gov/pubmed/19215780 PubMed 19251848 http://www.ncbi.nlm.nih.gov/pubmed/19251848 PubMed 19707553 http://www.ncbi.nlm.nih.gov/pubmed/19707553 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 21419338 http://www.ncbi.nlm.nih.gov/pubmed/21419338 PubMed 21944167 http://www.ncbi.nlm.nih.gov/pubmed/21944167 PubMed 22412352 http://www.ncbi.nlm.nih.gov/pubmed/22412352 PubMed 23280569 http://www.ncbi.nlm.nih.gov/pubmed/23280569 PubMed 23416055 http://www.ncbi.nlm.nih.gov/pubmed/23416055 PubMed 23432955 http://www.ncbi.nlm.nih.gov/pubmed/23432955 PubMed 24375411 http://www.ncbi.nlm.nih.gov/pubmed/24375411 PubMed 25564525 http://www.ncbi.nlm.nih.gov/pubmed/25564525 PubMed 2844820 http://www.ncbi.nlm.nih.gov/pubmed/2844820 PubMed 8226627 http://www.ncbi.nlm.nih.gov/pubmed/8226627 PubMed 8650219 http://www.ncbi.nlm.nih.gov/pubmed/8650219 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417262 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417262 RefSeq WP_000254738 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000254738 SMR P0AE70 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AE70 STRING 511145.b2782 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2782&targetmode=cogs STRING COG2337 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2337&targetmode=cogs SUPFAM SSF50118 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50118 UniProtKB MAZF_ECOLI http://www.uniprot.org/uniprot/MAZF_ECOLI UniProtKB-AC P0AE70 http://www.uniprot.org/uniprot/P0AE70 charge swissprot:MAZF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MAZF_ECOLI eggNOG COG2337 http://eggnogapi.embl.de/nog_data/html/tree/COG2337 eggNOG ENOG4105MZG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105MZG epestfind swissprot:MAZF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MAZF_ECOLI garnier swissprot:MAZF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MAZF_ECOLI helixturnhelix swissprot:MAZF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MAZF_ECOLI hmoment swissprot:MAZF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MAZF_ECOLI iep swissprot:MAZF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MAZF_ECOLI inforesidue swissprot:MAZF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MAZF_ECOLI octanol swissprot:MAZF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MAZF_ECOLI pepcoil swissprot:MAZF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MAZF_ECOLI pepdigest swissprot:MAZF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MAZF_ECOLI pepinfo swissprot:MAZF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MAZF_ECOLI pepnet swissprot:MAZF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MAZF_ECOLI pepstats swissprot:MAZF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MAZF_ECOLI pepwheel swissprot:MAZF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MAZF_ECOLI pepwindow swissprot:MAZF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MAZF_ECOLI sigcleave swissprot:MAZF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MAZF_ECOLI ## Database ID URL or Descriptions # AltName RIMO_ECOLI Ribosomal protein S12 (aspartate(89)-C(3))-methylthiotransferase # AltName RIMO_ECOLI Ribosome maturation factor RimO # BRENDA 2.8.4 2026 # BioGrid 4261845 6 # CATALYTIC ACTIVITY L-aspartate-[ribosomal protein S12] + sulfur- (sulfur carrier) + 2 S-adenosyl-L-methionine = 3-methylthio-L- aspartate-[ribosomal protein S12] + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine. {ECO:0000269|PubMed 19736993}. # COFACTOR RIMO_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000269|PubMed 19736993}; Note=Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. {ECO 0000269|PubMed 19736993}; # DISRUPTION PHENOTYPE Mutant shows a lack of methylthiolation of protein S12 and a decrease in transcription of a subset of genes. {ECO:0000269|PubMed 21169565}. # EcoGene EG13478 rimO # FUNCTION RIMO_ECOLI Catalyzes the methylthiolation of the residue Asp-89 of ribosomal protein S12. {ECO 0000269|PubMed 18252828, ECO 0000269|PubMed 21169565}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0005506 iron ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0035599 aspartic acid methylthiotransferase activity; IDA:EcoCyc. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IDA:EcoCyc. # GO_process GO:0018339 peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid; IDA:EcoCyc. # GO_process GO:0035600 tRNA methylthiolation; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0006464 cellular protein modification process # Gene3D 3.80.30.20 -; 1. # HAMAP MF_01865 MTTase_RimO # IntAct P0AEI4 20 # InterPro IPR002792 TRAM_dom # InterPro IPR005839 Methylthiotransferase # InterPro IPR005840 Ribosomal_S12_MeSTrfase_RimO # InterPro IPR006638 Elp3/MiaB/NifB # InterPro IPR007197 rSAM # InterPro IPR013848 Methylthiotransferase_N # InterPro IPR020612 Methylthiotransferase_CS # InterPro IPR023404 rSAM_horseshoe # InterPro IPR023970 MeThioTfrase/rSAM # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # Organism RIMO_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11918 PTHR11918 # PATRIC 32116873 VBIEscCol129921_0862 # PIR C64821 C64821 # PROSITE PS01278 MTTASE_RADICAL # PROSITE PS50926 TRAM # PROSITE PS51449 MTTASE_N # Pfam PF00919 UPF0004 # Pfam PF04055 Radical_SAM # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RIMO_ECOLI Ribosomal protein S12 methylthiotransferase RimO # RefSeq NP_415356 NC_000913.3 # RefSeq WP_000049367 NZ_LN832404.1 # SIMILARITY Belongs to the methylthiotransferase family. RimO subfamily. {ECO 0000305}. # SIMILARITY Contains 1 MTTase N-terminal domain. {ECO 0000305}. # SIMILARITY Contains 1 TRAM domain. {ECO 0000305}. # SMART SM00729 Elp3 # SUBCELLULAR LOCATION RIMO_ECOLI Cytoplasm {ECO 0000305}. # TIGRFAMs TIGR00089 TIGR00089 # TIGRFAMs TIGR01125 TIGR01125 # eggNOG COG0621 LUCA # eggNOG ENOG4105CBM Bacteria BLAST swissprot:RIMO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RIMO_ECOLI BioCyc ECOL316407:JW0819-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0819-MONOMER BioCyc EcoCyc:G6435-MONOMER http://biocyc.org/getid?id=EcoCyc:G6435-MONOMER BioCyc MetaCyc:G6435-MONOMER http://biocyc.org/getid?id=MetaCyc:G6435-MONOMER COG COG0621 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0621 DIP DIP-48218N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48218N DOI 10.1021/bi900939w http://dx.doi.org/10.1021/bi900939w DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0708608105 http://dx.doi.org/10.1073/pnas.0708608105 DOI 10.1074/mcp.M110.005199 http://dx.doi.org/10.1074/mcp.M110.005199 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.8.4.4 {ECO:0000269|PubMed:19736993} http://www.genome.jp/dbget-bin/www_bget?EC:2.8.4.4 {ECO:0000269|PubMed:19736993} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.8.4.4 {ECO:0000269|PubMed:19736993} http://enzyme.expasy.org/EC/2.8.4.4 {ECO:0000269|PubMed:19736993} EchoBASE EB3251 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3251 EcoGene EG13478 http://www.ecogene.org/geneInfo.php?eg_id=EG13478 EnsemblBacteria AAC73922 http://www.ensemblgenomes.org/id/AAC73922 EnsemblBacteria AAC73922 http://www.ensemblgenomes.org/id/AAC73922 EnsemblBacteria BAA35530 http://www.ensemblgenomes.org/id/BAA35530 EnsemblBacteria BAA35530 http://www.ensemblgenomes.org/id/BAA35530 EnsemblBacteria BAA35530 http://www.ensemblgenomes.org/id/BAA35530 EnsemblBacteria b0835 http://www.ensemblgenomes.org/id/b0835 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0035599 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035599 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0018339 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018339 GO_process GO:0035600 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035600 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 Gene3D 3.80.30.20 http://www.cathdb.info/version/latest/superfamily/3.80.30.20 GeneID 945465 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945465 HAMAP MF_01865 http://hamap.expasy.org/unirule/MF_01865 HOGENOM HOG000224766 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000224766&db=HOGENOM6 InParanoid P0AEI4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEI4 IntAct P0AEI4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEI4* IntEnz 2.8.4.4 {ECO:0000269|PubMed:19736993} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.8.4.4 {ECO:0000269|PubMed:19736993} InterPro IPR002792 http://www.ebi.ac.uk/interpro/entry/IPR002792 InterPro IPR005839 http://www.ebi.ac.uk/interpro/entry/IPR005839 InterPro IPR005840 http://www.ebi.ac.uk/interpro/entry/IPR005840 InterPro IPR006638 http://www.ebi.ac.uk/interpro/entry/IPR006638 InterPro IPR007197 http://www.ebi.ac.uk/interpro/entry/IPR007197 InterPro IPR013848 http://www.ebi.ac.uk/interpro/entry/IPR013848 InterPro IPR020612 http://www.ebi.ac.uk/interpro/entry/IPR020612 InterPro IPR023404 http://www.ebi.ac.uk/interpro/entry/IPR023404 InterPro IPR023970 http://www.ebi.ac.uk/interpro/entry/IPR023970 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW0819 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0819 KEGG_Gene eco:b0835 http://www.genome.jp/dbget-bin/www_bget?eco:b0835 KEGG_Orthology KO:K14441 http://www.genome.jp/dbget-bin/www_bget?KO:K14441 OMA HYAYPTG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HYAYPTG PANTHER PTHR11918 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11918 PROSITE PS01278 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01278 PROSITE PS50926 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50926 PROSITE PS51449 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51449 PSORT swissprot:RIMO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RIMO_ECOLI PSORT-B swissprot:RIMO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RIMO_ECOLI PSORT2 swissprot:RIMO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RIMO_ECOLI Pfam PF00919 http://pfam.xfam.org/family/PF00919 Pfam PF04055 http://pfam.xfam.org/family/PF04055 Phobius swissprot:RIMO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RIMO_ECOLI PhylomeDB P0AEI4 http://phylomedb.org/?seqid=P0AEI4 ProteinModelPortal P0AEI4 http://www.proteinmodelportal.org/query/uniprot/P0AEI4 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18252828 http://www.ncbi.nlm.nih.gov/pubmed/18252828 PubMed 19736993 http://www.ncbi.nlm.nih.gov/pubmed/19736993 PubMed 21169565 http://www.ncbi.nlm.nih.gov/pubmed/21169565 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415356 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415356 RefSeq WP_000049367 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000049367 SMART SM00729 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00729 SMR P0AEI4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEI4 STRING 511145.b0835 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0835&targetmode=cogs STRING COG0621 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0621&targetmode=cogs TIGRFAMs TIGR00089 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00089 TIGRFAMs TIGR01125 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01125 UniProtKB RIMO_ECOLI http://www.uniprot.org/uniprot/RIMO_ECOLI UniProtKB-AC P0AEI4 http://www.uniprot.org/uniprot/P0AEI4 charge swissprot:RIMO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RIMO_ECOLI eggNOG COG0621 http://eggnogapi.embl.de/nog_data/html/tree/COG0621 eggNOG ENOG4105CBM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CBM epestfind swissprot:RIMO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RIMO_ECOLI garnier swissprot:RIMO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RIMO_ECOLI helixturnhelix swissprot:RIMO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RIMO_ECOLI hmoment swissprot:RIMO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RIMO_ECOLI iep swissprot:RIMO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RIMO_ECOLI inforesidue swissprot:RIMO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RIMO_ECOLI octanol swissprot:RIMO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RIMO_ECOLI pepcoil swissprot:RIMO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RIMO_ECOLI pepdigest swissprot:RIMO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RIMO_ECOLI pepinfo swissprot:RIMO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RIMO_ECOLI pepnet swissprot:RIMO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RIMO_ECOLI pepstats swissprot:RIMO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RIMO_ECOLI pepwheel swissprot:RIMO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RIMO_ECOLI pepwindow swissprot:RIMO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RIMO_ECOLI sigcleave swissprot:RIMO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RIMO_ECOLI ## Database ID URL or Descriptions # AltName RNC_ECOLI Ribonuclease III # BRENDA 3.1.26 2026 # BioGrid 4260597 13 # CATALYTIC ACTIVITY Endonucleolytic cleavage to 5'- phosphomonoester. {ECO:0000269|PubMed 4592261}. # CAUTION RNC_ECOLI The original rnc-105 mutation is described as G44->D but the nucleotide sequence given indicates G44->S (PubMed 3903434). A later paper calls the same mutation G45->K (PubMed 9632264), which alters the residue and mutation. {ECO 0000305|PubMed 3903434, ECO 0000305|PubMed 9632264}. # CDD cd00593 RIBOc # COFACTOR RNC_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 11305928, ECO 0000269|PubMed 15699182, ECO 0000269|PubMed 932008}; Note=Divalent metal cations, preferably Mg(2+). While only 1 Mg(2+) is detected by crystallography, other evidence indicates there may be more than 1 metal necessary for catalysis. Binding of the second metal my be promoted by substrate binding. {ECO 0000269|PubMed 11305928, ECO 0000269|PubMed 15699182, ECO 0000269|PubMed 932008}; # DISRUPTION PHENOTYPE RNC_ECOLI Slower than wild-type growth. Transient accumulation of the 30S rRNA precursor occurs; 90% of 16S rRNA is correctly processed while an extended version of 23S rRNA accumulates in the ribosome. Half-life of a number of RNase III processed transcripts increases. In the absence of era and rnc there is a defect in chromosome partitioning. In strain HT115, loss of immunity against a plasmid with homology to CRISPR spacer sequences (PubMed 23535272). {ECO 0000269|PubMed 23535272, ECO 0000269|PubMed 2540151, ECO 0000269|PubMed 4587248, ECO 0000269|PubMed 6364133, ECO 0000269|PubMed 9515700, ECO 0000269|PubMed 9632264}. # ENZYME REGULATION RNC_ECOLI Non-competitively inhibited by 2-hydroxy-4H- isoquinoline-1,3-dione. Activity is down-regulated during cold shock by direct interaction with YmdB. Also down-regulated during entry into stationary phase by an YmdB-independent mechanism. {ECO 0000269|PubMed 15699182, ECO 0000269|PubMed 19141481}. # EcoGene EG10857 rnc # FUNCTION RNC_ECOLI Digests double-stranded RNA formed within single-strand substrates, but not RNA-DNA hybrids. Involved in the processing of rRNA precursors, viral transcripts, some mRNAs and at least 1 tRNA (metY, a minor form of tRNA-init-Met). Cleaves the 30S primary rRNA transcript to yield the immediate precursors to the 16S and 23S rRNAs; cleavage can occur in assembled 30S, 50S and even 70S subunits and is influenced by the presence of ribosomal proteins. The E.coli enzyme does not cleave R.capsulatus rRNA precursor, although R.capsulatus will complement an E.coli disruption, showing substrate recognition is different. Removes the intervening sequences from Salmonella typhimurium rRNA precursor. Complements the pre-crRNA processing defect in an rnc deletion in S.pyogenes strain 370, although this E.coli strain does not have the corresponding CRISPR locus (strain TOP10) (PubMed 23535272). {ECO 0000269|PubMed 2085545, ECO 0000269|PubMed 23535272, ECO 0000269|PubMed 2406020, ECO 0000269|PubMed 2481042, ECO 0000269|PubMed 3903434, ECO 0000269|PubMed 4587248, ECO 0000269|PubMed 4592261, ECO 0000269|PubMed 4610145, ECO 0000269|PubMed 4865702, ECO 0000269|PubMed 6159890, ECO 0000269|PubMed 932008}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003725 double-stranded RNA binding; IBA:GO_Central. # GO_function GO:0004525 ribonuclease III activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0019843 rRNA binding; IEA:UniProtKB-KW. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006364 rRNA processing; IEA:UniProtKB-HAMAP. # GO_process GO:0006396 RNA processing; IDA:EcoCyc. # GO_process GO:0006397 mRNA processing; IEA:UniProtKB-HAMAP. # GO_process GO:0008033 tRNA processing; IEA:UniProtKB-KW. # GO_process GO:0016075 rRNA catabolic process; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0004518 nuclease activity # GOslim_function GO:0019843 rRNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006397 mRNA processing # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # Gene3D 1.10.1520.10 -; 1. # Gene3D 3.30.160.20 -; 1. # HAMAP MF_00104 RNase_III # INDUCTION RNC_ECOLI Expression increases as the growth rate increases. Encoded in the rnc-era-recO operon. Processes the 5' end of its own transcript leading to mRNA instability. {ECO 0000269|PubMed 2085545, ECO 0000269|PubMed 9515700}. # IntAct P0A7Y0 6 # InterPro IPR000999 RNase_III_dom # InterPro IPR011907 RNase_III # InterPro IPR014720 dsRBD_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # KEGG_Pathway ko03008 Ribosome biogenesis in eukaryotes # Organism RNC_ECOLI Escherichia coli (strain K12) # PATRIC 32120533 VBIEscCol129921_2669 # PIR F65034 NREC3 # PROSITE PS00517 RNASE_3_1 # PROSITE PS50137 DS_RBD # PROSITE PS50142 RNASE_3_2 # Pfam PF00035 dsrm # Pfam PF14622 Ribonucleas_3_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RNC_ECOLI Ribonuclease 3 # RefSeq NP_417062 NC_000913.3 # RefSeq WP_001068343 NZ_LN832404.1 # SIMILARITY Contains 1 DRBM (double-stranded RNA-binding) domain. {ECO 0000305}. # SIMILARITY Contains 1 RNase III domain. {ECO 0000305}. # SMART SM00358 DSRM # SMART SM00535 RIBOc # SUBCELLULAR LOCATION RNC_ECOLI Cytoplasm {ECO 0000269|PubMed 4865702}. Note=Loosely associated with ribosomes. # SUBUNIT Homodimer. {ECO:0000269|PubMed 932008}. # SUPFAM SSF69065 SSF69065 # TIGRFAMs TIGR02191 RNaseIII # eggNOG COG0571 LUCA # eggNOG ENOG4108ZBM Bacteria BLAST swissprot:RNC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RNC_ECOLI BioCyc ECOL316407:JW2551-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2551-MONOMER BioCyc EcoCyc:EG10857-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10857-MONOMER BioCyc MetaCyc:EG10857-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10857-MONOMER COG COG0571 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0571 DIP DIP-48223N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48223N DOI 10.1007/BF00397981 http://dx.doi.org/10.1007/BF00397981 DOI 10.1016/0006-291X(80)90060-1 http://dx.doi.org/10.1016/0006-291X(80)90060-1 DOI 10.1016/0022-2836(74)90350-7 http://dx.doi.org/10.1016/0022-2836(74)90350-7 DOI 10.1016/0022-2836(89)90331-8 http://dx.doi.org/10.1016/0022-2836(89)90331-8 DOI 10.1016/0092-8674(90)90592-3 http://dx.doi.org/10.1016/0092-8674(90)90592-3 DOI 10.1016/0300-9084(90)90192-J http://dx.doi.org/10.1016/0300-9084(90)90192-J DOI 10.1016/S0969-2126(01)00685-2 http://dx.doi.org/10.1016/S0969-2126(01)00685-2 DOI 10.1021/bi010022d http://dx.doi.org/10.1021/bi010022d DOI 10.1021/bi049258i http://dx.doi.org/10.1021/bi049258i DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1998.00719.x http://dx.doi.org/10.1046/j.1365-2958.1998.00719.x DOI 10.1046/j.1365-2958.1998.00828.x http://dx.doi.org/10.1046/j.1365-2958.1998.00828.x DOI 10.1073/pnas.70.12.3296 http://dx.doi.org/10.1073/pnas.70.12.3296 DOI 10.1073/pnas.81.1.185 http://dx.doi.org/10.1073/pnas.81.1.185 DOI 10.1073/pnas.83.23.8849 http://dx.doi.org/10.1073/pnas.83.23.8849 DOI 10.1093/nar/13.13.4677 http://dx.doi.org/10.1093/nar/13.13.4677 DOI 10.1093/nar/26.19.4446 http://dx.doi.org/10.1093/nar/26.19.4446 DOI 10.1093/nar/gki197 http://dx.doi.org/10.1093/nar/gki197 DOI 10.1101/gad.1729508 http://dx.doi.org/10.1101/gad.1729508 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1186/1471-2199-4-8 http://dx.doi.org/10.1186/1471-2199-4-8 DOI 10.4161/rna.24203 http://dx.doi.org/10.4161/rna.24203 EC_number EC:3.1.26.3 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.26.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D64044 http://www.ebi.ac.uk/ena/data/view/D64044 EMBL M14658 http://www.ebi.ac.uk/ena/data/view/M14658 EMBL M26415 http://www.ebi.ac.uk/ena/data/view/M26415 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36841 http://www.ebi.ac.uk/ena/data/view/U36841 EMBL X02673 http://www.ebi.ac.uk/ena/data/view/X02673 EMBL X02946 http://www.ebi.ac.uk/ena/data/view/X02946 ENZYME 3.1.26.3 http://enzyme.expasy.org/EC/3.1.26.3 EchoBASE EB0850 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0850 EcoGene EG10857 http://www.ecogene.org/geneInfo.php?eg_id=EG10857 EnsemblBacteria AAC75620 http://www.ensemblgenomes.org/id/AAC75620 EnsemblBacteria AAC75620 http://www.ensemblgenomes.org/id/AAC75620 EnsemblBacteria BAE76743 http://www.ensemblgenomes.org/id/BAE76743 EnsemblBacteria BAE76743 http://www.ensemblgenomes.org/id/BAE76743 EnsemblBacteria BAE76743 http://www.ensemblgenomes.org/id/BAE76743 EnsemblBacteria b2567 http://www.ensemblgenomes.org/id/b2567 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003725 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003725 GO_function GO:0004525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004525 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006364 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006364 GO_process GO:0006396 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006396 GO_process GO:0006397 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006397 GO_process GO:0008033 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008033 GO_process GO:0016075 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016075 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006397 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006397 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 Gene3D 1.10.1520.10 http://www.cathdb.info/version/latest/superfamily/1.10.1520.10 Gene3D 3.30.160.20 http://www.cathdb.info/version/latest/superfamily/3.30.160.20 GeneID 947033 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947033 HAMAP MF_00104 http://hamap.expasy.org/unirule/MF_00104 HOGENOM HOG000246809 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000246809&db=HOGENOM6 InParanoid P0A7Y0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7Y0 IntAct P0A7Y0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7Y0* IntEnz 3.1.26.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.26.3 InterPro IPR000999 http://www.ebi.ac.uk/interpro/entry/IPR000999 InterPro IPR011907 http://www.ebi.ac.uk/interpro/entry/IPR011907 InterPro IPR014720 http://www.ebi.ac.uk/interpro/entry/IPR014720 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW2551 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2551 KEGG_Gene eco:b2567 http://www.genome.jp/dbget-bin/www_bget?eco:b2567 KEGG_Orthology KO:K03685 http://www.genome.jp/dbget-bin/www_bget?KO:K03685 KEGG_Pathway ko03008 http://www.genome.jp/kegg-bin/show_pathway?ko03008 MINT MINT-1227120 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1227120 OMA LTHKSCK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LTHKSCK PROSITE PS00517 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00517 PROSITE PS50137 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50137 PROSITE PS50142 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50142 PSORT swissprot:RNC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RNC_ECOLI PSORT-B swissprot:RNC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RNC_ECOLI PSORT2 swissprot:RNC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RNC_ECOLI Pfam PF00035 http://pfam.xfam.org/family/PF00035 Pfam PF14622 http://pfam.xfam.org/family/PF14622 Phobius swissprot:RNC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RNC_ECOLI PhylomeDB P0A7Y0 http://phylomedb.org/?seqid=P0A7Y0 ProteinModelPortal P0A7Y0 http://www.proteinmodelportal.org/query/uniprot/P0A7Y0 PubMed 11305928 http://www.ncbi.nlm.nih.gov/pubmed/11305928 PubMed 11738048 http://www.ncbi.nlm.nih.gov/pubmed/11738048 PubMed 12814522 http://www.ncbi.nlm.nih.gov/pubmed/12814522 PubMed 15476399 http://www.ncbi.nlm.nih.gov/pubmed/15476399 PubMed 15699182 http://www.ncbi.nlm.nih.gov/pubmed/15699182 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19141481 http://www.ncbi.nlm.nih.gov/pubmed/19141481 PubMed 2085545 http://www.ncbi.nlm.nih.gov/pubmed/2085545 PubMed 2105934 http://www.ncbi.nlm.nih.gov/pubmed/2105934 PubMed 23535272 http://www.ncbi.nlm.nih.gov/pubmed/23535272 PubMed 2406020 http://www.ncbi.nlm.nih.gov/pubmed/2406020 PubMed 2481042 http://www.ncbi.nlm.nih.gov/pubmed/2481042 PubMed 2540151 http://www.ncbi.nlm.nih.gov/pubmed/2540151 PubMed 3097637 http://www.ncbi.nlm.nih.gov/pubmed/3097637 PubMed 3895158 http://www.ncbi.nlm.nih.gov/pubmed/3895158 PubMed 3903434 http://www.ncbi.nlm.nih.gov/pubmed/3903434 PubMed 4587248 http://www.ncbi.nlm.nih.gov/pubmed/4587248 PubMed 4592261 http://www.ncbi.nlm.nih.gov/pubmed/4592261 PubMed 4610145 http://www.ncbi.nlm.nih.gov/pubmed/4610145 PubMed 4865702 http://www.ncbi.nlm.nih.gov/pubmed/4865702 PubMed 6159890 http://www.ncbi.nlm.nih.gov/pubmed/6159890 PubMed 6364133 http://www.ncbi.nlm.nih.gov/pubmed/6364133 PubMed 7628457 http://www.ncbi.nlm.nih.gov/pubmed/7628457 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 932008 http://www.ncbi.nlm.nih.gov/pubmed/932008 PubMed 9515700 http://www.ncbi.nlm.nih.gov/pubmed/9515700 PubMed 9632264 http://www.ncbi.nlm.nih.gov/pubmed/9632264 PubMed 9742248 http://www.ncbi.nlm.nih.gov/pubmed/9742248 RefSeq NP_417062 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417062 RefSeq WP_001068343 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001068343 SMART SM00358 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00358 SMART SM00535 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00535 SMR P0A7Y0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7Y0 STRING 511145.b2567 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2567&targetmode=cogs STRING COG0571 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0571&targetmode=cogs SUPFAM SSF69065 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF69065 TIGRFAMs TIGR02191 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02191 UniProtKB RNC_ECOLI http://www.uniprot.org/uniprot/RNC_ECOLI UniProtKB-AC P0A7Y0 http://www.uniprot.org/uniprot/P0A7Y0 charge swissprot:RNC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RNC_ECOLI eggNOG COG0571 http://eggnogapi.embl.de/nog_data/html/tree/COG0571 eggNOG ENOG4108ZBM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZBM epestfind swissprot:RNC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RNC_ECOLI garnier swissprot:RNC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RNC_ECOLI helixturnhelix swissprot:RNC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RNC_ECOLI hmoment swissprot:RNC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RNC_ECOLI iep swissprot:RNC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RNC_ECOLI inforesidue swissprot:RNC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RNC_ECOLI octanol swissprot:RNC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RNC_ECOLI pepcoil swissprot:RNC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RNC_ECOLI pepdigest swissprot:RNC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RNC_ECOLI pepinfo swissprot:RNC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RNC_ECOLI pepnet swissprot:RNC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RNC_ECOLI pepstats swissprot:RNC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RNC_ECOLI pepwheel swissprot:RNC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RNC_ECOLI pepwindow swissprot:RNC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RNC_ECOLI sigcleave swissprot:RNC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RNC_ECOLI ## Database ID URL or Descriptions # BioGrid 4263490 212 # EcoGene EG13409 slyB # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # INDUCTION Induced by low extracellular levels of magnesium via the PhoQ/PhoP two-component regulatory system. {ECO:0000269|PubMed 12813061}. # IntAct P0A905 4 # InterPro IPR008816 Gly_zipper_2TM_dom # Organism SLYB_ECOLI Escherichia coli (strain K12) # PATRIC 32118584 VBIEscCol129921_1712 # PIR C64921 C64921 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF05433 Rick_17kDa_Anti # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SLYB_ECOLI Outer membrane lipoprotein SlyB # RefSeq WP_000597196 NZ_LN832404.1 # RefSeq YP_025304 NC_000913.3 # SIMILARITY Belongs to the Pcp/SlyB lipoprotein family. {ECO 0000305}. # SUBCELLULAR LOCATION SLYB_ECOLI Cell outer membrane {ECO 0000305}; Lipid- anchor {ECO 0000255|PROSITE-ProRule PRU00303}. # eggNOG COG3133 LUCA # eggNOG ENOG4108XTF Bacteria BLAST swissprot:SLYB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SLYB_ECOLI BioCyc ECOL316407:JW1633-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1633-MONOMER BioCyc EcoCyc:G6881-MONOMER http://biocyc.org/getid?id=EcoCyc:G6881-MONOMER COG COG3133 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3133 DOI 10.1007/BF00290573 http://dx.doi.org/10.1007/BF00290573 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.185.13.3696-3702.2003 http://dx.doi.org/10.1128/JB.185.13.3696-3702.2003 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3185 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3185 EcoGene EG13409 http://www.ecogene.org/geneInfo.php?eg_id=EG13409 EnsemblBacteria AAT48133 http://www.ensemblgenomes.org/id/AAT48133 EnsemblBacteria AAT48133 http://www.ensemblgenomes.org/id/AAT48133 EnsemblBacteria BAA15402 http://www.ensemblgenomes.org/id/BAA15402 EnsemblBacteria BAA15402 http://www.ensemblgenomes.org/id/BAA15402 EnsemblBacteria BAA15402 http://www.ensemblgenomes.org/id/BAA15402 EnsemblBacteria b1641 http://www.ensemblgenomes.org/id/b1641 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GeneID 946801 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946801 HOGENOM HOG000220583 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220583&db=HOGENOM6 InParanoid P0A905 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A905 IntAct P0A905 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A905* InterPro IPR008816 http://www.ebi.ac.uk/interpro/entry/IPR008816 KEGG_Gene ecj:JW1633 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1633 KEGG_Gene eco:b1641 http://www.genome.jp/dbget-bin/www_bget?eco:b1641 KEGG_Orthology KO:K06077 http://www.genome.jp/dbget-bin/www_bget?KO:K06077 OMA GCAYNSS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GCAYNSS PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:SLYB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SLYB_ECOLI PSORT-B swissprot:SLYB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SLYB_ECOLI PSORT2 swissprot:SLYB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SLYB_ECOLI Pfam PF05433 http://pfam.xfam.org/family/PF05433 Phobius swissprot:SLYB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SLYB_ECOLI ProteinModelPortal P0A905 http://www.proteinmodelportal.org/query/uniprot/P0A905 PubMed 12813061 http://www.ncbi.nlm.nih.gov/pubmed/12813061 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8544813 http://www.ncbi.nlm.nih.gov/pubmed/8544813 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000597196 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000597196 RefSeq YP_025304 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_025304 STRING 511145.b1641 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1641&targetmode=cogs STRING COG3133 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3133&targetmode=cogs UniProtKB SLYB_ECOLI http://www.uniprot.org/uniprot/SLYB_ECOLI UniProtKB-AC P0A905 http://www.uniprot.org/uniprot/P0A905 charge swissprot:SLYB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SLYB_ECOLI eggNOG COG3133 http://eggnogapi.embl.de/nog_data/html/tree/COG3133 eggNOG ENOG4108XTF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108XTF epestfind swissprot:SLYB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SLYB_ECOLI garnier swissprot:SLYB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SLYB_ECOLI helixturnhelix swissprot:SLYB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SLYB_ECOLI hmoment swissprot:SLYB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SLYB_ECOLI iep swissprot:SLYB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SLYB_ECOLI inforesidue swissprot:SLYB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SLYB_ECOLI octanol swissprot:SLYB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SLYB_ECOLI pepcoil swissprot:SLYB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SLYB_ECOLI pepdigest swissprot:SLYB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SLYB_ECOLI pepinfo swissprot:SLYB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SLYB_ECOLI pepnet swissprot:SLYB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SLYB_ECOLI pepstats swissprot:SLYB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SLYB_ECOLI pepwheel swissprot:SLYB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SLYB_ECOLI pepwindow swissprot:SLYB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SLYB_ECOLI sigcleave swissprot:SLYB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SLYB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260901 8 # EcoGene EG13534 ybdO # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IBA:GO_Central. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # INDUCTION YBDO_ECOLI Induced by LeuO, a monocistronic operon (PubMed 19429622). Maximally induced in early stationary phase, repressed by H-NS via 2 binding sites in the upstream and coding region; H-NS may bind both regions to form a bridge which then prevents transcription (PubMed 26789284). {ECO 0000269|PubMed 19429622, ECO 0000269|PubMed 26789284}. # IntAct P77746 5 # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR005119 LysR_subst-bd # InterPro IPR011991 WHTH_DNA-bd_dom # MISCELLANEOUS The protein is quite variable across different genetic subgroups, probably due to its binding and repression by H-NS (PubMed:26789284). {ECO 0000305|PubMed:26789284}. # Organism YBDO_ECOLI Escherichia coli (strain K12) # PATRIC 32116384 VBIEscCol129921_0632 # PIR A64794 A64794 # PRINTS PR00039 HTHLYSR # PROSITE PS50931 HTH_LYSR # Pfam PF00126 HTH_1 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBDO_ECOLI Uncharacterized HTH-type transcriptional regulator YbdO # RefSeq NP_415136 NC_000913.3 # RefSeq WP_000002474 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lysR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00253}. # SUPFAM SSF46785 SSF46785 # eggNOG ENOG4105DQS Bacteria # eggNOG ENOG410XQ6Z LUCA BLAST swissprot:YBDO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBDO_ECOLI BioCyc ECOL316407:JW0596-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0596-MONOMER BioCyc EcoCyc:G6332-MONOMER http://biocyc.org/getid?id=EcoCyc:G6332-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00108-09 http://dx.doi.org/10.1128/JB.00108-09 DOI 10.1371/journal.pgen.1005796 http://dx.doi.org/10.1371/journal.pgen.1005796 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB3305 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3305 EcoGene EG13534 http://www.ecogene.org/geneInfo.php?eg_id=EG13534 EnsemblBacteria AAC73704 http://www.ensemblgenomes.org/id/AAC73704 EnsemblBacteria AAC73704 http://www.ensemblgenomes.org/id/AAC73704 EnsemblBacteria BAA35233 http://www.ensemblgenomes.org/id/BAA35233 EnsemblBacteria BAA35233 http://www.ensemblgenomes.org/id/BAA35233 EnsemblBacteria BAA35233 http://www.ensemblgenomes.org/id/BAA35233 EnsemblBacteria b0603 http://www.ensemblgenomes.org/id/b0603 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 945216 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945216 HOGENOM HOG000117868 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117868&db=HOGENOM6 IntAct P77746 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77746* InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW0596 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0596 KEGG_Gene eco:b0603 http://www.genome.jp/dbget-bin/www_bget?eco:b0603 OMA QLYLMYN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QLYLMYN PRINTS PR00039 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00039 PROSITE PS50931 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50931 PSORT swissprot:YBDO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBDO_ECOLI PSORT-B swissprot:YBDO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBDO_ECOLI PSORT2 swissprot:YBDO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBDO_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:YBDO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBDO_ECOLI PhylomeDB P77746 http://phylomedb.org/?seqid=P77746 ProteinModelPortal P77746 http://www.proteinmodelportal.org/query/uniprot/P77746 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19429622 http://www.ncbi.nlm.nih.gov/pubmed/19429622 PubMed 26789284 http://www.ncbi.nlm.nih.gov/pubmed/26789284 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415136 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415136 RefSeq WP_000002474 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000002474 SMR P77746 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77746 STRING 511145.b0603 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0603&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB YBDO_ECOLI http://www.uniprot.org/uniprot/YBDO_ECOLI UniProtKB-AC P77746 http://www.uniprot.org/uniprot/P77746 charge swissprot:YBDO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBDO_ECOLI eggNOG ENOG4105DQS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DQS eggNOG ENOG410XQ6Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQ6Z epestfind swissprot:YBDO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBDO_ECOLI garnier swissprot:YBDO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBDO_ECOLI helixturnhelix swissprot:YBDO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBDO_ECOLI hmoment swissprot:YBDO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBDO_ECOLI iep swissprot:YBDO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBDO_ECOLI inforesidue swissprot:YBDO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBDO_ECOLI octanol swissprot:YBDO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBDO_ECOLI pepcoil swissprot:YBDO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBDO_ECOLI pepdigest swissprot:YBDO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBDO_ECOLI pepinfo swissprot:YBDO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBDO_ECOLI pepnet swissprot:YBDO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBDO_ECOLI pepstats swissprot:YBDO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBDO_ECOLI pepwheel swissprot:YBDO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBDO_ECOLI pepwindow swissprot:YBDO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBDO_ECOLI sigcleave swissprot:YBDO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBDO_ECOLI ## Database ID URL or Descriptions # BioGrid 4259889 231 # EcoGene EG12448 ybcH # IntAct P37325 4 # InterPro IPR027849 DUF4434 # Organism YBCH_ECOLI Escherichia coli (strain K12) # PATRIC 32116302 VBIEscCol129921_0591 # PIR E64789 E64789 # Pfam PF14488 DUF4434 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBCH_ECOLI Uncharacterized protein YbcH # RefSeq NP_415099 NC_000913.3 # RefSeq WP_001224604 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=L16945; Type=Frameshift; Positions=131; Evidence={ECO 0000305}; # eggNOG ENOG4105QUW Bacteria # eggNOG ENOG4111Z9C LUCA BLAST swissprot:YBCH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBCH_ECOLI BioCyc ECOL316407:JW0556-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0556-MONOMER BioCyc EcoCyc:EG12448-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12448-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L16945 http://www.ebi.ac.uk/ena/data/view/L16945 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB2342 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2342 EcoGene EG12448 http://www.ecogene.org/geneInfo.php?eg_id=EG12448 EnsemblBacteria AAC73668 http://www.ensemblgenomes.org/id/AAC73668 EnsemblBacteria AAC73668 http://www.ensemblgenomes.org/id/AAC73668 EnsemblBacteria BAA35201 http://www.ensemblgenomes.org/id/BAA35201 EnsemblBacteria BAA35201 http://www.ensemblgenomes.org/id/BAA35201 EnsemblBacteria BAA35201 http://www.ensemblgenomes.org/id/BAA35201 EnsemblBacteria b0567 http://www.ensemblgenomes.org/id/b0567 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945186 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945186 HOGENOM HOG000117800 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117800&db=HOGENOM6 IntAct P37325 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37325* InterPro IPR027849 http://www.ebi.ac.uk/interpro/entry/IPR027849 KEGG_Gene ecj:JW0556 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0556 KEGG_Gene eco:b0567 http://www.genome.jp/dbget-bin/www_bget?eco:b0567 OMA LYMDPAY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LYMDPAY PSORT swissprot:YBCH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBCH_ECOLI PSORT-B swissprot:YBCH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBCH_ECOLI PSORT2 swissprot:YBCH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBCH_ECOLI Pfam PF14488 http://pfam.xfam.org/family/PF14488 Phobius swissprot:YBCH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBCH_ECOLI ProteinModelPortal P37325 http://www.proteinmodelportal.org/query/uniprot/P37325 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8226649 http://www.ncbi.nlm.nih.gov/pubmed/8226649 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415099 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415099 RefSeq WP_001224604 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001224604 STRING 511145.b0567 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0567&targetmode=cogs UniProtKB YBCH_ECOLI http://www.uniprot.org/uniprot/YBCH_ECOLI UniProtKB-AC P37325 http://www.uniprot.org/uniprot/P37325 charge swissprot:YBCH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBCH_ECOLI eggNOG ENOG4105QUW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105QUW eggNOG ENOG4111Z9C http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111Z9C epestfind swissprot:YBCH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBCH_ECOLI garnier swissprot:YBCH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBCH_ECOLI helixturnhelix swissprot:YBCH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBCH_ECOLI hmoment swissprot:YBCH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBCH_ECOLI iep swissprot:YBCH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBCH_ECOLI inforesidue swissprot:YBCH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBCH_ECOLI octanol swissprot:YBCH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBCH_ECOLI pepcoil swissprot:YBCH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBCH_ECOLI pepdigest swissprot:YBCH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBCH_ECOLI pepinfo swissprot:YBCH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBCH_ECOLI pepnet swissprot:YBCH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBCH_ECOLI pepstats swissprot:YBCH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBCH_ECOLI pepwheel swissprot:YBCH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBCH_ECOLI pepwindow swissprot:YBCH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBCH_ECOLI sigcleave swissprot:YBCH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBCH_ECOLI ## Database ID URL or Descriptions # BioGrid 4260096 9 # EcoGene EG14292 ymgD # InterPro IPR032497 YmgD # Organism YMGD_ECOLI Escherichia coli (strain K12) # PATRIC 32117582 VBIEscCol129921_1213 # PDB 2LRM NMR; -; A/B=20-109 # PDB 2LRV NMR; -; A=20-109 # PIR H64862 H64862 # Pfam PF16456 YmgD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YMGD_ECOLI Uncharacterized protein YmgD # RefSeq NP_415689 NC_000913.3 # RefSeq WP_001295611 NZ_LN832404.1 # eggNOG ENOG410658X Bacteria # eggNOG ENOG4112AJ2 LUCA BLAST swissprot:YMGD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YMGD_ECOLI BioCyc ECOL316407:JW5177-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5177-MONOMER BioCyc EcoCyc:G6611-MONOMER http://biocyc.org/getid?id=EcoCyc:G6611-MONOMER DIP DIP-48276N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48276N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4040 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4040 EcoGene EG14292 http://www.ecogene.org/geneInfo.php?eg_id=EG14292 EnsemblBacteria AAC74255 http://www.ensemblgenomes.org/id/AAC74255 EnsemblBacteria AAC74255 http://www.ensemblgenomes.org/id/AAC74255 EnsemblBacteria BAA36005 http://www.ensemblgenomes.org/id/BAA36005 EnsemblBacteria BAA36005 http://www.ensemblgenomes.org/id/BAA36005 EnsemblBacteria BAA36005 http://www.ensemblgenomes.org/id/BAA36005 EnsemblBacteria b1171 http://www.ensemblgenomes.org/id/b1171 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945732 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945732 HOGENOM HOG000119701 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000119701&db=HOGENOM6 InterPro IPR032497 http://www.ebi.ac.uk/interpro/entry/IPR032497 KEGG_Gene ecj:JW5177 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5177 KEGG_Gene eco:b1171 http://www.genome.jp/dbget-bin/www_bget?eco:b1171 OMA CTEANEM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CTEANEM PDB 2LRM http://www.ebi.ac.uk/pdbe-srv/view/entry/2LRM PDB 2LRV http://www.ebi.ac.uk/pdbe-srv/view/entry/2LRV PDBsum 2LRM http://www.ebi.ac.uk/pdbsum/2LRM PDBsum 2LRV http://www.ebi.ac.uk/pdbsum/2LRV PSORT swissprot:YMGD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YMGD_ECOLI PSORT-B swissprot:YMGD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YMGD_ECOLI PSORT2 swissprot:YMGD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YMGD_ECOLI Pfam PF16456 http://pfam.xfam.org/family/PF16456 Phobius swissprot:YMGD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YMGD_ECOLI ProteinModelPortal P0AB46 http://www.proteinmodelportal.org/query/uniprot/P0AB46 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415689 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415689 RefSeq WP_001295611 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295611 SMR P0AB46 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AB46 STRING 511145.b1171 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1171&targetmode=cogs UniProtKB YMGD_ECOLI http://www.uniprot.org/uniprot/YMGD_ECOLI UniProtKB-AC P0AB46 http://www.uniprot.org/uniprot/P0AB46 charge swissprot:YMGD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YMGD_ECOLI eggNOG ENOG410658X http://eggnogapi.embl.de/nog_data/html/tree/ENOG410658X eggNOG ENOG4112AJ2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4112AJ2 epestfind swissprot:YMGD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YMGD_ECOLI garnier swissprot:YMGD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YMGD_ECOLI helixturnhelix swissprot:YMGD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YMGD_ECOLI hmoment swissprot:YMGD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YMGD_ECOLI iep swissprot:YMGD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YMGD_ECOLI inforesidue swissprot:YMGD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YMGD_ECOLI octanol swissprot:YMGD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YMGD_ECOLI pepcoil swissprot:YMGD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YMGD_ECOLI pepdigest swissprot:YMGD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YMGD_ECOLI pepinfo swissprot:YMGD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YMGD_ECOLI pepnet swissprot:YMGD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YMGD_ECOLI pepstats swissprot:YMGD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YMGD_ECOLI pepwheel swissprot:YMGD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YMGD_ECOLI pepwindow swissprot:YMGD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YMGD_ECOLI sigcleave swissprot:YMGD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YMGD_ECOLI ## Database ID URL or Descriptions # EcoGene EG40003 insC4 # FUNCTION INSC4_ECOLI Involved in the transposition of the insertion sequence IS2. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 1.10.10.60 -; 1. # InterPro IPR002514 Transposase_8 # InterPro IPR009057 Homeodomain-like # Organism INSC4_ECOLI Escherichia coli (strain K12) # PIR B65240 B65240 # Pfam PF01527 HTH_Tnp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSC4_ECOLI Transposase InsC for insertion element IS2H # RefSeq NP_414894 NC_000913.3 # RefSeq NP_415921 NC_000913.3 # RefSeq NP_417338 NC_000913.3 # RefSeq NP_417516 NC_000913.3 # RefSeq NP_418692 NC_000913.3 # RefSeq WP_000567766 NZ_LN832404.1 # RefSeq YP_026163 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA83043.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAE76928.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the transposase 8 family. {ECO 0000305}. # SUPFAM SSF46689 SSF46689 # eggNOG COG2963 LUCA # eggNOG ENOG4108ZQS Bacteria BLAST swissprot:INSC4_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSC4_ECOLI BioCyc EcoCyc:MONOMER0-4252 http://biocyc.org/getid?id=EcoCyc:MONOMER0-4252 DIP DIP-28108N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-28108N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 EchoBASE EB4738 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4738 EcoGene EG40003 http://www.ecogene.org/geneInfo.php?eg_id=EG40003 EnsemblBacteria AAC75900 http://www.ensemblgenomes.org/id/AAC75900 EnsemblBacteria AAC75900 http://www.ensemblgenomes.org/id/AAC75900 EnsemblBacteria BAE76928 http://www.ensemblgenomes.org/id/BAE76928 EnsemblBacteria BAE76928 http://www.ensemblgenomes.org/id/BAE76928 EnsemblBacteria BAE76928 http://www.ensemblgenomes.org/id/BAE76928 EnsemblBacteria b2861 http://www.ensemblgenomes.org/id/b2861 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 GeneID 945025 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945025 GeneID 945967 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945967 GeneID 946455 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946455 GeneID 947347 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947347 GeneID 947520 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947520 GeneID 948781 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948781 InParanoid P0CF43 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CF43 InterPro IPR002514 http://www.ebi.ac.uk/interpro/entry/IPR002514 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 KEGG_Gene ecj:JW2829 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2829 KEGG_Gene eco:b0360 http://www.genome.jp/dbget-bin/www_bget?eco:b0360 KEGG_Gene eco:b1403 http://www.genome.jp/dbget-bin/www_bget?eco:b1403 KEGG_Gene eco:b1997 http://www.genome.jp/dbget-bin/www_bget?eco:b1997 KEGG_Gene eco:b2861 http://www.genome.jp/dbget-bin/www_bget?eco:b2861 KEGG_Gene eco:b3044 http://www.genome.jp/dbget-bin/www_bget?eco:b3044 KEGG_Gene eco:b4272 http://www.genome.jp/dbget-bin/www_bget?eco:b4272 PSORT swissprot:INSC4_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSC4_ECOLI PSORT-B swissprot:INSC4_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSC4_ECOLI PSORT2 swissprot:INSC4_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSC4_ECOLI Pfam PF01527 http://pfam.xfam.org/family/PF01527 Phobius swissprot:INSC4_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSC4_ECOLI PhylomeDB P0CF43 http://phylomedb.org/?seqid=P0CF43 ProteinModelPortal P0CF43 http://www.proteinmodelportal.org/query/uniprot/P0CF43 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414894 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414894 RefSeq NP_415921 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415921 RefSeq NP_417338 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417338 RefSeq NP_417516 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417516 RefSeq NP_418692 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418692 RefSeq WP_000567766 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000567766 RefSeq YP_026163 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026163 STRING 511145.b4272 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4272&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 UniProtKB INSC4_ECOLI http://www.uniprot.org/uniprot/INSC4_ECOLI UniProtKB-AC P0CF43 http://www.uniprot.org/uniprot/P0CF43 charge swissprot:INSC4_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSC4_ECOLI eggNOG COG2963 http://eggnogapi.embl.de/nog_data/html/tree/COG2963 eggNOG ENOG4108ZQS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZQS epestfind swissprot:INSC4_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSC4_ECOLI garnier swissprot:INSC4_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSC4_ECOLI helixturnhelix swissprot:INSC4_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSC4_ECOLI hmoment swissprot:INSC4_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSC4_ECOLI iep swissprot:INSC4_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSC4_ECOLI inforesidue swissprot:INSC4_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSC4_ECOLI octanol swissprot:INSC4_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSC4_ECOLI pepcoil swissprot:INSC4_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSC4_ECOLI pepdigest swissprot:INSC4_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSC4_ECOLI pepinfo swissprot:INSC4_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSC4_ECOLI pepnet swissprot:INSC4_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSC4_ECOLI pepstats swissprot:INSC4_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSC4_ECOLI pepwheel swissprot:INSC4_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSC4_ECOLI pepwindow swissprot:INSC4_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSC4_ECOLI sigcleave swissprot:INSC4_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSC4_ECOLI ## Database ID URL or Descriptions # BioGrid 4261753 5 # EcoGene EG14334 yceO # GO_process GO:0010447 response to acidic pH; IMP:EcoCyc. # GO_process GO:0044010 single-species biofilm formation; IMP:EcoCyc. # GOslim_process GO:0008150 biological_process # INDUCTION Expressed during exponential phase (at protein level). {ECO:0000269|PubMed 19121005}. # InterPro IPR024494 DUF2770 # Organism YCEO_ECOLI Escherichia coli (strain K12) # PATRIC 32117355 VBIEscCol129921_1100 # PIR G64848 G64848 # Pfam PF10968 DUF2770 # ProDom PD049682 PD049682 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCEO_ECOLI Uncharacterized protein YceO # RefSeq NP_415576 NC_000913.3 # eggNOG ENOG4106974 Bacteria # eggNOG ENOG410Y4ZR LUCA BLAST swissprot:YCEO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCEO_ECOLI BioCyc ECOL316407:JW1045-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1045-MONOMER BioCyc EcoCyc:G6555-MONOMER http://biocyc.org/getid?id=EcoCyc:G6555-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2008.06495.x http://dx.doi.org/10.1111/j.1365-2958.2008.06495.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4080 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4080 EcoGene EG14334 http://www.ecogene.org/geneInfo.php?eg_id=EG14334 EnsemblBacteria AAC74142 http://www.ensemblgenomes.org/id/AAC74142 EnsemblBacteria AAC74142 http://www.ensemblgenomes.org/id/AAC74142 EnsemblBacteria BAE76372 http://www.ensemblgenomes.org/id/BAE76372 EnsemblBacteria BAE76372 http://www.ensemblgenomes.org/id/BAE76372 EnsemblBacteria BAE76372 http://www.ensemblgenomes.org/id/BAE76372 EnsemblBacteria b1058 http://www.ensemblgenomes.org/id/b1058 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0010447 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010447 GO_process GO:0044010 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044010 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 945629 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945629 HOGENOM HOG000267898 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267898&db=HOGENOM6 InterPro IPR024494 http://www.ebi.ac.uk/interpro/entry/IPR024494 KEGG_Gene ecj:JW1045 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1045 KEGG_Gene eco:b1058 http://www.genome.jp/dbget-bin/www_bget?eco:b1058 PSORT swissprot:YCEO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCEO_ECOLI PSORT-B swissprot:YCEO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCEO_ECOLI PSORT2 swissprot:YCEO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCEO_ECOLI Pfam PF10968 http://pfam.xfam.org/family/PF10968 Phobius swissprot:YCEO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCEO_ECOLI ProteinModelPortal P64442 http://www.proteinmodelportal.org/query/uniprot/P64442 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19121005 http://www.ncbi.nlm.nih.gov/pubmed/19121005 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415576 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415576 STRING 511145.b1058 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1058&targetmode=cogs UniProtKB YCEO_ECOLI http://www.uniprot.org/uniprot/YCEO_ECOLI UniProtKB-AC P64442 http://www.uniprot.org/uniprot/P64442 charge swissprot:YCEO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCEO_ECOLI eggNOG ENOG4106974 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106974 eggNOG ENOG410Y4ZR http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y4ZR epestfind swissprot:YCEO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCEO_ECOLI garnier swissprot:YCEO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCEO_ECOLI helixturnhelix swissprot:YCEO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCEO_ECOLI hmoment swissprot:YCEO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCEO_ECOLI iep swissprot:YCEO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCEO_ECOLI inforesidue swissprot:YCEO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCEO_ECOLI octanol swissprot:YCEO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCEO_ECOLI pepcoil swissprot:YCEO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCEO_ECOLI pepdigest swissprot:YCEO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCEO_ECOLI pepinfo swissprot:YCEO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCEO_ECOLI pepnet swissprot:YCEO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCEO_ECOLI pepstats swissprot:YCEO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCEO_ECOLI pepwheel swissprot:YCEO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCEO_ECOLI pepwindow swissprot:YCEO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCEO_ECOLI sigcleave swissprot:YCEO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCEO_ECOLI ## Database ID URL or Descriptions # BioGrid 4259115 17 # EcoGene EG11644 ydeI # GO_process GO:0044011 single-species biofilm formation on inanimate substrate; IMP:EcoCyc. # GO_process GO:0070301 cellular response to hydrogen peroxide; IMP:EcoCyc. # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # Gene3D 2.40.50.200 -; 1. # IntAct P31130 2 # InterPro IPR005220 BOF # InterPro IPR016052 Phage_933W_L0136 # Organism YDEI_ECOLI Escherichia coli (strain K12) # PATRIC 32118372 VBIEscCol129921_1606 # PIR C64908 C64908 # Pfam PF04076 BOF # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDEI_ECOLI Uncharacterized protein YdeI # RefSeq NP_416054 NC_000913.3 # RefSeq WP_000671737 NZ_LN832404.1 # SUPFAM SSF101756 SSF101756 # TIGRFAMs TIGR00156 TIGR00156 # eggNOG COG3111 LUCA # eggNOG ENOG4108YDI Bacteria BLAST swissprot:YDEI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDEI_ECOLI BioCyc ECOL316407:JW1529-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1529-MONOMER BioCyc EcoCyc:EG11644-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11644-MONOMER DIP DIP-11678N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11678N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M96235 http://www.ebi.ac.uk/ena/data/view/M96235 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1597 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1597 EcoGene EG11644 http://www.ecogene.org/geneInfo.php?eg_id=EG11644 EnsemblBacteria AAC74609 http://www.ensemblgenomes.org/id/AAC74609 EnsemblBacteria AAC74609 http://www.ensemblgenomes.org/id/AAC74609 EnsemblBacteria BAA15226 http://www.ensemblgenomes.org/id/BAA15226 EnsemblBacteria BAA15226 http://www.ensemblgenomes.org/id/BAA15226 EnsemblBacteria BAA15226 http://www.ensemblgenomes.org/id/BAA15226 EnsemblBacteria b1536 http://www.ensemblgenomes.org/id/b1536 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0044011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044011 GO_process GO:0070301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070301 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 2.40.50.200 http://www.cathdb.info/version/latest/superfamily/2.40.50.200 GeneID 946068 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946068 HOGENOM HOG000216776 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000216776&db=HOGENOM6 IntAct P31130 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31130* InterPro IPR005220 http://www.ebi.ac.uk/interpro/entry/IPR005220 InterPro IPR016052 http://www.ebi.ac.uk/interpro/entry/IPR016052 KEGG_Gene ecj:JW1529 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1529 KEGG_Gene eco:b1536 http://www.genome.jp/dbget-bin/www_bget?eco:b1536 MINT MINT-1260141 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1260141 OMA MHDGATV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MHDGATV PSORT swissprot:YDEI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDEI_ECOLI PSORT-B swissprot:YDEI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDEI_ECOLI PSORT2 swissprot:YDEI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDEI_ECOLI Pfam PF04076 http://pfam.xfam.org/family/PF04076 Phobius swissprot:YDEI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDEI_ECOLI ProteinModelPortal P31130 http://www.proteinmodelportal.org/query/uniprot/P31130 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8383113 http://www.ncbi.nlm.nih.gov/pubmed/8383113 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416054 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416054 RefSeq WP_000671737 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000671737 SMR P31130 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31130 STRING 511145.b1536 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1536&targetmode=cogs SUPFAM SSF101756 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF101756 TIGRFAMs TIGR00156 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00156 UniProtKB YDEI_ECOLI http://www.uniprot.org/uniprot/YDEI_ECOLI UniProtKB-AC P31130 http://www.uniprot.org/uniprot/P31130 charge swissprot:YDEI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDEI_ECOLI eggNOG COG3111 http://eggnogapi.embl.de/nog_data/html/tree/COG3111 eggNOG ENOG4108YDI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108YDI epestfind swissprot:YDEI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDEI_ECOLI garnier swissprot:YDEI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDEI_ECOLI helixturnhelix swissprot:YDEI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDEI_ECOLI hmoment swissprot:YDEI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDEI_ECOLI iep swissprot:YDEI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDEI_ECOLI inforesidue swissprot:YDEI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDEI_ECOLI octanol swissprot:YDEI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDEI_ECOLI pepcoil swissprot:YDEI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDEI_ECOLI pepdigest swissprot:YDEI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDEI_ECOLI pepinfo swissprot:YDEI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDEI_ECOLI pepnet swissprot:YDEI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDEI_ECOLI pepstats swissprot:YDEI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDEI_ECOLI pepwheel swissprot:YDEI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDEI_ECOLI pepwindow swissprot:YDEI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDEI_ECOLI sigcleave swissprot:YDEI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDEI_ECOLI ## Database ID URL or Descriptions # BioGrid 4261837 3 # EcoGene EG11484 yigZ # Gene3D 3.30.230.30 -; 1. # Gene3D 3.30.70.240 -; 1. # IntAct P27862 3 # InterPro IPR000640 EFG_V # InterPro IPR001498 Impact_N # InterPro IPR009022 EFG_III-V # InterPro IPR015269 UPF0029_Impact_C # InterPro IPR015796 Impact_bac/arc # InterPro IPR020568 Ribosomal_S5_D2-typ_fold # InterPro IPR020569 UPF0029_Impact_CS # InterPro IPR023582 Impact # Organism YIGZ_ECOLI Escherichia coli (strain K12) # PANTHER PTHR16301 PTHR16301 # PATRIC 32123193 VBIEscCol129921_3962 # PDB 1VI7 X-ray; 2.80 A; A=1-204 # PIR S30739 S30739 # PROSITE PS00910 UPF0029 # Pfam PF01205 UPF0029 # Pfam PF09186 DUF1949 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIGZ_ECOLI IMPACT family member YigZ # RefSeq NP_418290 NC_000913.3 # RefSeq WP_001308167 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA67645.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA38501.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the IMPACT family. {ECO 0000305}. # SUBUNIT Monomer. {ECO:0000269|PubMed 15103642}. # SUPFAM SSF54211 SSF54211 # SUPFAM SSF54980 SSF54980 # TIGRFAMs TIGR00257 IMPACT_YIGZ # eggNOG COG1739 LUCA # eggNOG ENOG4108ZK7 Bacteria BLAST swissprot:YIGZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIGZ_ECOLI BioCyc ECOL316407:JW5577-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5577-MONOMER BioCyc EcoCyc:EG11484-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11484-MONOMER DIP DIP-12487N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12487N DOI 10.1002/prot.20087 http://dx.doi.org/10.1002/prot.20087 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/18.21.6439 http://dx.doi.org/10.1093/nar/18.21.6439 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X54687 http://www.ebi.ac.uk/ena/data/view/X54687 EchoBASE EB1447 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1447 EcoGene EG11484 http://www.ecogene.org/geneInfo.php?eg_id=EG11484 EnsemblBacteria AAC76851 http://www.ensemblgenomes.org/id/AAC76851 EnsemblBacteria AAC76851 http://www.ensemblgenomes.org/id/AAC76851 EnsemblBacteria BAE77455 http://www.ensemblgenomes.org/id/BAE77455 EnsemblBacteria BAE77455 http://www.ensemblgenomes.org/id/BAE77455 EnsemblBacteria BAE77455 http://www.ensemblgenomes.org/id/BAE77455 EnsemblBacteria b3848 http://www.ensemblgenomes.org/id/b3848 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.30.230.30 http://www.cathdb.info/version/latest/superfamily/3.30.230.30 Gene3D 3.30.70.240 http://www.cathdb.info/version/latest/superfamily/3.30.70.240 GeneID 948334 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948334 HOGENOM HOG000075267 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000075267&db=HOGENOM6 InParanoid P27862 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P27862 IntAct P27862 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P27862* InterPro IPR000640 http://www.ebi.ac.uk/interpro/entry/IPR000640 InterPro IPR001498 http://www.ebi.ac.uk/interpro/entry/IPR001498 InterPro IPR009022 http://www.ebi.ac.uk/interpro/entry/IPR009022 InterPro IPR015269 http://www.ebi.ac.uk/interpro/entry/IPR015269 InterPro IPR015796 http://www.ebi.ac.uk/interpro/entry/IPR015796 InterPro IPR020568 http://www.ebi.ac.uk/interpro/entry/IPR020568 InterPro IPR020569 http://www.ebi.ac.uk/interpro/entry/IPR020569 InterPro IPR023582 http://www.ebi.ac.uk/interpro/entry/IPR023582 KEGG_Gene ecj:JW5577 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5577 KEGG_Gene eco:b3848 http://www.genome.jp/dbget-bin/www_bget?eco:b3848 MINT MINT-1251693 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1251693 OMA DHQRAGK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DHQRAGK PANTHER PTHR16301 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16301 PDB 1VI7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1VI7 PDBsum 1VI7 http://www.ebi.ac.uk/pdbsum/1VI7 PROSITE PS00910 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00910 PSORT swissprot:YIGZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIGZ_ECOLI PSORT-B swissprot:YIGZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIGZ_ECOLI PSORT2 swissprot:YIGZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIGZ_ECOLI Pfam PF01205 http://pfam.xfam.org/family/PF01205 Pfam PF09186 http://pfam.xfam.org/family/PF09186 Phobius swissprot:YIGZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIGZ_ECOLI PhylomeDB P27862 http://phylomedb.org/?seqid=P27862 ProteinModelPortal P27862 http://www.proteinmodelportal.org/query/uniprot/P27862 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 15103642 http://www.ncbi.nlm.nih.gov/pubmed/15103642 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2243799 http://www.ncbi.nlm.nih.gov/pubmed/2243799 PubMed 8313894 http://www.ncbi.nlm.nih.gov/pubmed/8313894 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418290 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418290 RefSeq WP_001308167 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001308167 SMR P27862 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P27862 STRING 511145.b3848 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3848&targetmode=cogs SUPFAM SSF54211 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54211 SUPFAM SSF54980 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54980 TIGRFAMs TIGR00257 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00257 UniProtKB YIGZ_ECOLI http://www.uniprot.org/uniprot/YIGZ_ECOLI UniProtKB-AC P27862 http://www.uniprot.org/uniprot/P27862 charge swissprot:YIGZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIGZ_ECOLI eggNOG COG1739 http://eggnogapi.embl.de/nog_data/html/tree/COG1739 eggNOG ENOG4108ZK7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZK7 epestfind swissprot:YIGZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIGZ_ECOLI garnier swissprot:YIGZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIGZ_ECOLI helixturnhelix swissprot:YIGZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIGZ_ECOLI hmoment swissprot:YIGZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIGZ_ECOLI iep swissprot:YIGZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIGZ_ECOLI inforesidue swissprot:YIGZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIGZ_ECOLI octanol swissprot:YIGZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIGZ_ECOLI pepcoil swissprot:YIGZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIGZ_ECOLI pepdigest swissprot:YIGZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIGZ_ECOLI pepinfo swissprot:YIGZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIGZ_ECOLI pepnet swissprot:YIGZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIGZ_ECOLI pepstats swissprot:YIGZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIGZ_ECOLI pepwheel swissprot:YIGZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIGZ_ECOLI pepwindow swissprot:YIGZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIGZ_ECOLI sigcleave swissprot:YIGZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIGZ_ECOLI ## Database ID URL or Descriptions # BioGrid 4260048 6 # CAUTION Was originally thought to suppress the temperature- sensitive growth phenotype of fabA6(Ts) mutants. {ECO:0000305|PubMed 8808925}. # EcoGene EG13232 ymcE # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # INDUCTION Transiently induced by cold shock in a PNPase-dependent fashion. {ECO:0000269|PubMed 14527658}. # InterPro IPR031853 YmcE_antitoxin # Organism YMCE_ECOLI Escherichia coli (strain K12) # PIR E64840 E64840 # Pfam PF15939 YmcE_antitoxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YMCE_ECOLI Uncharacterized protein YmcE # RefSeq NP_415511 NC_000913.3 # RefSeq WP_001309400 NZ_LN832404.1 # SUBCELLULAR LOCATION YMCE_ECOLI Cell membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. BLAST swissprot:YMCE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YMCE_ECOLI BioCyc ECOL316407:JW0975-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0975-MONOMER BioCyc EcoCyc:G6512-MONOMER http://biocyc.org/getid?id=EcoCyc:G6512-MONOMER DOI 10.1016/S0923-2508(03)00167-0 http://dx.doi.org/10.1016/S0923-2508(03)00167-0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.183.19.5523-5528.2001 http://dx.doi.org/10.1128/JB.183.19.5523-5528.2001 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U38541 http://www.ebi.ac.uk/ena/data/view/U38541 EchoBASE EB3021 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3021 EcoGene EG13232 http://www.ecogene.org/geneInfo.php?eg_id=EG13232 EnsemblBacteria AAC74076 http://www.ensemblgenomes.org/id/AAC74076 EnsemblBacteria AAC74076 http://www.ensemblgenomes.org/id/AAC74076 EnsemblBacteria BAA35757 http://www.ensemblgenomes.org/id/BAA35757 EnsemblBacteria BAA35757 http://www.ensemblgenomes.org/id/BAA35757 EnsemblBacteria BAA35757 http://www.ensemblgenomes.org/id/BAA35757 EnsemblBacteria b0991 http://www.ensemblgenomes.org/id/b0991 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 946951 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946951 HOGENOM HOG000009722 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009722&db=HOGENOM6 InterPro IPR031853 http://www.ebi.ac.uk/interpro/entry/IPR031853 KEGG_Gene ecj:JW0975 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0975 KEGG_Gene eco:b0991 http://www.genome.jp/dbget-bin/www_bget?eco:b0991 OMA REMAYNI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=REMAYNI PSORT swissprot:YMCE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YMCE_ECOLI PSORT-B swissprot:YMCE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YMCE_ECOLI PSORT2 swissprot:YMCE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YMCE_ECOLI Pfam PF15939 http://pfam.xfam.org/family/PF15939 Phobius swissprot:YMCE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YMCE_ECOLI ProteinModelPortal P0AAA5 http://www.proteinmodelportal.org/query/uniprot/P0AAA5 PubMed 11544213 http://www.ncbi.nlm.nih.gov/pubmed/11544213 PubMed 14527658 http://www.ncbi.nlm.nih.gov/pubmed/14527658 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8808925 http://www.ncbi.nlm.nih.gov/pubmed/8808925 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415511 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415511 RefSeq WP_001309400 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001309400 STRING 511145.b0991 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0991&targetmode=cogs UniProtKB YMCE_ECOLI http://www.uniprot.org/uniprot/YMCE_ECOLI UniProtKB-AC P0AAA5 http://www.uniprot.org/uniprot/P0AAA5 charge swissprot:YMCE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YMCE_ECOLI epestfind swissprot:YMCE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YMCE_ECOLI garnier swissprot:YMCE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YMCE_ECOLI helixturnhelix swissprot:YMCE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YMCE_ECOLI hmoment swissprot:YMCE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YMCE_ECOLI iep swissprot:YMCE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YMCE_ECOLI inforesidue swissprot:YMCE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YMCE_ECOLI octanol swissprot:YMCE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YMCE_ECOLI pepcoil swissprot:YMCE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YMCE_ECOLI pepdigest swissprot:YMCE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YMCE_ECOLI pepinfo swissprot:YMCE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YMCE_ECOLI pepnet swissprot:YMCE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YMCE_ECOLI pepstats swissprot:YMCE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YMCE_ECOLI pepwheel swissprot:YMCE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YMCE_ECOLI pepwindow swissprot:YMCE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YMCE_ECOLI sigcleave swissprot:YMCE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YMCE_ECOLI ## Database ID URL or Descriptions # AltName Hibernation factor HPF {ECO:0000303|PubMed 22605777} # BioGrid 4259283 8 # CDD cd00552 RaiA # DISRUPTION PHENOTYPE HPF_ECOLI Non-essential gene, no formation of inactive 100S ribosomes. Double hpf-yfiA deletion mutants form 90S ribosomes (PubMed 16324148). A quadruple yfiA-hpf-rmf-sra knockout strain is significantly outcompeted by wild-type after 4 days growth (PubMed 17277072). No change in sensitivity to aminoglycoside antiobiotic gentamicin in stationary phase cultures (PubMed 26324267). {ECO 0000269|PubMed 16324148, ECO 0000269|PubMed 17277072, ECO 0000269|PubMed 26324267}. # EcoGene EG11681 hpf # FUNCTION HPF_ECOLI During stationary phase, promotes and stabilizes dimerization of 70S ribosomes by the ribosome modulation factor (RMF), leading to the formation of inactive 100S ribosomes (PubMed 18174192). Converts immature 90S particles formed by RMF into 100S ribosomes (PubMed 16324148). Crystallization with T.thermophilus 70S ribosomes shows it binds in the channel between the head and body of the 30S subunit, where mRNA, tRNAs, initiation factors IF1 and IF3 and elongation factor G would bind; however RMF is still able to bind (PubMed 22605777). In this crystal binding of HPF induces movement of the 30S head domain away from the rest of the ribosome, presumably so they would more easily form dimers (PubMed 22605777). May also function as a potential translational inhibitor (PubMed 18174192). {ECO 0000269|PubMed 11168583, ECO 0000269|PubMed 16324148, ECO 0000269|PubMed 18174192, ECO 0000269|PubMed 19170772, ECO 0000269|PubMed 22605777}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0022627 cytosolic small ribosomal subunit; IBA:GO_Central. # GO_function GO:0043022 ribosome binding; IDA:EcoCyc. # GO_function GO:0043024 ribosomal small subunit binding; IDA:EcoCyc. # GO_process GO:0017148 negative regulation of translation; IDA:EcoCyc. # GO_process GO:0044238 primary metabolic process; IEA:InterPro. # GO_process GO:0045900 negative regulation of translational elongation; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0008150 biological_process # Gene3D 3.30.160.100 -; 1. # INDUCTION HPF_ECOLI Induced during stationary growth phase (at protein level) (PubMed 11168583). Induced by the signal autoinducer AI-2 (PubMed 11514505). {ECO 0000269|PubMed 11168583, ECO 0000269|PubMed 11514505}. # IntAct P0AFX0 4 # InterPro IPR003489 Ribosomal_S30Ae/sigma54_mod # KEGG_Brite ko03009 Ribosome biogenesis # Organism HPF_ECOLI Escherichia coli (strain K12) # PATRIC 32121826 VBIEscCol129921_3297 # PDB 2RQL NMR; -; A=1-95 # PDB 4V8H X-ray; 3.10 A; AX/CX=1-95 # PIR I76719 I76719 # Pfam PF02482 Ribosomal_S30AE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Ribosome hibernation promoting factor {ECO:0000303|PubMed 16324148} # RefSeq NP_417670 NC_000913.3 # RefSeq WP_001176599 NZ_LN832404.1 # SIMILARITY Belongs to the HPF/YfiA ribosome-associated protein family. Short HPF subfamily. {ECO 0000305}. # SUBUNIT HPF_ECOLI Associates exclusively with 100S ribosomes, which are dimers of 70S ribosomes. {ECO 0000269|PubMed 11168583, ECO 0000269|PubMed 22605777}. # SUPFAM SSF69754 SSF69754 # TIGRFAMs TIGR00741 yfiA # eggNOG COG1544 LUCA # eggNOG ENOG41080QH Bacteria BLAST swissprot:HPF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HPF_ECOLI BioCyc ECOL316407:JW3170-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3170-MONOMER BioCyc EcoCyc:EG11681-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11681-MONOMER COG COG1544 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1544 DIP DIP-48273N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48273N DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1016/j.bbrc.2009.09.022 http://dx.doi.org/10.1016/j.bbrc.2009.09.022 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2443.2000.00389.x http://dx.doi.org/10.1046/j.1365-2443.2000.00389.x DOI 10.1074/jbc.270.9.4822 http://dx.doi.org/10.1074/jbc.270.9.4822 DOI 10.1093/jb/mvm243 http://dx.doi.org/10.1093/jb/mvm243 DOI 10.1099/13500872-140-5-1035 http://dx.doi.org/10.1099/13500872-140-5-1035 DOI 10.1111/j.1365-2443.2005.00903.x http://dx.doi.org/10.1111/j.1365-2443.2005.00903.x DOI 10.1111/j.1365-2443.2008.01272.x http://dx.doi.org/10.1111/j.1365-2443.2008.01272.x DOI 10.1126/science.1218538 http://dx.doi.org/10.1126/science.1218538 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AAC.01532-15 http://dx.doi.org/10.1128/AAC.01532-15 DOI 10.1128/JB.01713-06 http://dx.doi.org/10.1128/JB.01713-06 DOI 10.1128/JB.183.18.5239-5247.2001 http://dx.doi.org/10.1128/JB.183.18.5239-5247.2001 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D12938 http://www.ebi.ac.uk/ena/data/view/D12938 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U12684 http://www.ebi.ac.uk/ena/data/view/U12684 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL Z27094 http://www.ebi.ac.uk/ena/data/view/Z27094 EchoBASE EB1632 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1632 EcoGene EG11681 http://www.ecogene.org/geneInfo.php?eg_id=EG11681 EnsemblBacteria AAC76235 http://www.ensemblgenomes.org/id/AAC76235 EnsemblBacteria AAC76235 http://www.ensemblgenomes.org/id/AAC76235 EnsemblBacteria BAE77247 http://www.ensemblgenomes.org/id/BAE77247 EnsemblBacteria BAE77247 http://www.ensemblgenomes.org/id/BAE77247 EnsemblBacteria BAE77247 http://www.ensemblgenomes.org/id/BAE77247 EnsemblBacteria b3203 http://www.ensemblgenomes.org/id/b3203 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0022627 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022627 GO_function GO:0043022 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043022 GO_function GO:0043024 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043024 GO_process GO:0017148 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017148 GO_process GO:0044238 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044238 GO_process GO:0045900 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045900 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.30.160.100 http://www.cathdb.info/version/latest/superfamily/3.30.160.100 GeneID 947718 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947718 HOGENOM HOG000264773 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000264773&db=HOGENOM6 InParanoid P0AFX0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFX0 IntAct P0AFX0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFX0* InterPro IPR003489 http://www.ebi.ac.uk/interpro/entry/IPR003489 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW3170 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3170 KEGG_Gene eco:b3203 http://www.genome.jp/dbget-bin/www_bget?eco:b3203 KEGG_Orthology KO:K05808 http://www.genome.jp/dbget-bin/www_bget?KO:K05808 MINT MINT-1249576 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1249576 OMA NLTGHHI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NLTGHHI PDB 2RQL http://www.ebi.ac.uk/pdbe-srv/view/entry/2RQL PDB 4V8H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V8H PDBsum 2RQL http://www.ebi.ac.uk/pdbsum/2RQL PDBsum 4V8H http://www.ebi.ac.uk/pdbsum/4V8H PSORT swissprot:HPF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HPF_ECOLI PSORT-B swissprot:HPF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HPF_ECOLI PSORT2 swissprot:HPF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HPF_ECOLI Pfam PF02482 http://pfam.xfam.org/family/PF02482 Phobius swissprot:HPF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HPF_ECOLI PhylomeDB P0AFX0 http://phylomedb.org/?seqid=P0AFX0 ProteinModelPortal P0AFX0 http://www.proteinmodelportal.org/query/uniprot/P0AFX0 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 11168583 http://www.ncbi.nlm.nih.gov/pubmed/11168583 PubMed 11514505 http://www.ncbi.nlm.nih.gov/pubmed/11514505 PubMed 16324148 http://www.ncbi.nlm.nih.gov/pubmed/16324148 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17277072 http://www.ncbi.nlm.nih.gov/pubmed/17277072 PubMed 18174192 http://www.ncbi.nlm.nih.gov/pubmed/18174192 PubMed 19170772 http://www.ncbi.nlm.nih.gov/pubmed/19170772 PubMed 19747895 http://www.ncbi.nlm.nih.gov/pubmed/19747895 PubMed 22605777 http://www.ncbi.nlm.nih.gov/pubmed/22605777 PubMed 26324267 http://www.ncbi.nlm.nih.gov/pubmed/26324267 PubMed 7876255 http://www.ncbi.nlm.nih.gov/pubmed/7876255 PubMed 8025669 http://www.ncbi.nlm.nih.gov/pubmed/8025669 PubMed 8444818 http://www.ncbi.nlm.nih.gov/pubmed/8444818 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417670 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417670 RefSeq WP_001176599 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001176599 SMR P0AFX0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFX0 STRING 511145.b3203 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3203&targetmode=cogs STRING COG1544 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1544&targetmode=cogs SUPFAM SSF69754 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF69754 TIGRFAMs TIGR00741 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00741 UniProtKB HPF_ECOLI http://www.uniprot.org/uniprot/HPF_ECOLI UniProtKB-AC P0AFX0 http://www.uniprot.org/uniprot/P0AFX0 charge swissprot:HPF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HPF_ECOLI eggNOG COG1544 http://eggnogapi.embl.de/nog_data/html/tree/COG1544 eggNOG ENOG41080QH http://eggnogapi.embl.de/nog_data/html/tree/ENOG41080QH epestfind swissprot:HPF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HPF_ECOLI garnier swissprot:HPF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HPF_ECOLI helixturnhelix swissprot:HPF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HPF_ECOLI hmoment swissprot:HPF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HPF_ECOLI iep swissprot:HPF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HPF_ECOLI inforesidue swissprot:HPF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HPF_ECOLI octanol swissprot:HPF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HPF_ECOLI pepcoil swissprot:HPF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HPF_ECOLI pepdigest swissprot:HPF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HPF_ECOLI pepinfo swissprot:HPF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HPF_ECOLI pepnet swissprot:HPF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HPF_ECOLI pepstats swissprot:HPF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HPF_ECOLI pepwheel swissprot:HPF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HPF_ECOLI pepwindow swissprot:HPF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HPF_ECOLI sigcleave swissprot:HPF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HPF_ECOLI ## Database ID URL or Descriptions # AltName PANE_ECOLI Ketopantoate reductase # BIOPHYSICOCHEMICAL PROPERTIES PANE_ECOLI Kinetic parameters KM=30 uM for ketopantoate {ECO 0000269|PubMed 11123955, ECO 0000269|PubMed 11724562, ECO 0000269|PubMed 17229734}; KM=7.3 uM for NADPH {ECO 0000269|PubMed 11123955, ECO 0000269|PubMed 11724562, ECO 0000269|PubMed 17229734}; # BRENDA 1.1.1.169 2026 # BioGrid 4262981 324 # CATALYTIC ACTIVITY PANE_ECOLI (R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH. # EcoGene EG13271 panE # FUNCTION PANE_ECOLI Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0008677 2-dehydropantoate 2-reductase activity; IDA:EcoCyc. # GO_function GO:0050661 NADP binding; IDA:EcoCyc. # GO_process GO:0033317 pantothenate biosynthetic process from valine; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 1.10.1040.10 -; 1. # Gene3D 3.40.50.720 -; 1. # IntAct P0A9J4 5 # InterPro IPR003710 ApbA # InterPro IPR008927 6-PGluconate_DH_C-like # InterPro IPR013328 6PGD_dom_2 # InterPro IPR013332 KPR_N # InterPro IPR013752 KPA_reductase # InterPro IPR016040 NAD(P)-bd_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00770 Pantothenate and CoA biosynthesis # MASS SPECTROMETRY Mass=33976; Method=Electrospray; Range=1-303; Evidence={ECO:0000269|PubMed 11724562}; # Organism PANE_ECOLI Escherichia coli (strain K12) # PATHWAY Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate step 2/2. # PATRIC 32116001 VBIEscCol129921_0442 # PDB 1KS9 X-ray; 1.70 A; A=1-291 # PDB 1YJQ X-ray; 2.09 A; A=1-303 # PDB 1YON X-ray; 1.95 A; A=1-303 # PDB 2OFP X-ray; 2.30 A; A/B=1-303 # PIR A64772 A64772 # Pfam PF02558 ApbA # Pfam PF08546 ApbA_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PANE_ECOLI 2-dehydropantoate 2-reductase # RefSeq NP_414959 NC_000913.3 # RefSeq WP_000705865 NZ_LN832404.1 # SIMILARITY Belongs to the ketopantoate reductase family. {ECO 0000305}. # SUBCELLULAR LOCATION PANE_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT PANE_ECOLI Monomer. {ECO 0000269|PubMed 11724562, ECO 0000269|PubMed 15966718, ECO 0000269|PubMed 17229734, ECO 0000269|PubMed 17242510}. # SUPFAM SSF48179 SSF48179 # SUPFAM SSF51735 SSF51735 # TIGRFAMs TIGR00745 apbA_panE # UniPathway UPA00028 UER00004 # eggNOG COG1893 LUCA # eggNOG ENOG4108JZF Bacteria BLAST swissprot:PANE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PANE_ECOLI BioCyc ECOL316407:JW0415-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0415-MONOMER BioCyc EcoCyc:2-DEHYDROPANTOATE-REDUCT-MONOMER http://biocyc.org/getid?id=EcoCyc:2-DEHYDROPANTOATE-REDUCT-MONOMER BioCyc MetaCyc:2-DEHYDROPANTOATE-REDUCT-MONOMER http://biocyc.org/getid?id=MetaCyc:2-DEHYDROPANTOATE-REDUCT-MONOMER COG COG1893 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1893 DOI 10.1021/bi002134v http://dx.doi.org/10.1021/bi002134v DOI 10.1021/bi011020w http://dx.doi.org/10.1021/bi011020w DOI 10.1021/bi0502036 http://dx.doi.org/10.1021/bi0502036 DOI 10.1021/bi992676g http://dx.doi.org/10.1021/bi992676g DOI 10.1021/jm060490r http://dx.doi.org/10.1021/jm060490r DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/BST0330767 http://dx.doi.org/10.1042/BST0330767 DOI 10.1074/jbc.M611171200 http://dx.doi.org/10.1074/jbc.M611171200 DOI 10.1107/S0907444906044465 http://dx.doi.org/10.1107/S0907444906044465 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.169 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.169 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U34923 http://www.ebi.ac.uk/ena/data/view/U34923 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 ENZYME 1.1.1.169 http://enzyme.expasy.org/EC/1.1.1.169 EchoBASE EB3056 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3056 EcoGene EG13271 http://www.ecogene.org/geneInfo.php?eg_id=EG13271 EnsemblBacteria AAC73528 http://www.ensemblgenomes.org/id/AAC73528 EnsemblBacteria AAC73528 http://www.ensemblgenomes.org/id/AAC73528 EnsemblBacteria BAE76205 http://www.ensemblgenomes.org/id/BAE76205 EnsemblBacteria BAE76205 http://www.ensemblgenomes.org/id/BAE76205 EnsemblBacteria BAE76205 http://www.ensemblgenomes.org/id/BAE76205 EnsemblBacteria b0425 http://www.ensemblgenomes.org/id/b0425 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008677 GO_function GO:0050661 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050661 GO_process GO:0033317 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033317 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 1.10.1040.10 http://www.cathdb.info/version/latest/superfamily/1.10.1040.10 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 945065 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945065 HOGENOM HOG000050223 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000050223&db=HOGENOM6 InParanoid P0A9J4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9J4 IntAct P0A9J4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9J4* IntEnz 1.1.1.169 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.169 InterPro IPR003710 http://www.ebi.ac.uk/interpro/entry/IPR003710 InterPro IPR008927 http://www.ebi.ac.uk/interpro/entry/IPR008927 InterPro IPR013328 http://www.ebi.ac.uk/interpro/entry/IPR013328 InterPro IPR013332 http://www.ebi.ac.uk/interpro/entry/IPR013332 InterPro IPR013752 http://www.ebi.ac.uk/interpro/entry/IPR013752 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0415 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0415 KEGG_Gene eco:b0425 http://www.genome.jp/dbget-bin/www_bget?eco:b0425 KEGG_Orthology KO:K00077 http://www.genome.jp/dbget-bin/www_bget?KO:K00077 KEGG_Pathway ko00770 http://www.genome.jp/kegg-bin/show_pathway?ko00770 KEGG_Reaction rn:R02472 http://www.genome.jp/dbget-bin/www_bget?rn:R02472 OMA RIPQPYC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RIPQPYC PDB 1KS9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1KS9 PDB 1YJQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1YJQ PDB 1YON http://www.ebi.ac.uk/pdbe-srv/view/entry/1YON PDB 2OFP http://www.ebi.ac.uk/pdbe-srv/view/entry/2OFP PDBsum 1KS9 http://www.ebi.ac.uk/pdbsum/1KS9 PDBsum 1YJQ http://www.ebi.ac.uk/pdbsum/1YJQ PDBsum 1YON http://www.ebi.ac.uk/pdbsum/1YON PDBsum 2OFP http://www.ebi.ac.uk/pdbsum/2OFP PSORT swissprot:PANE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PANE_ECOLI PSORT-B swissprot:PANE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PANE_ECOLI PSORT2 swissprot:PANE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PANE_ECOLI Pfam PF02558 http://pfam.xfam.org/family/PF02558 Pfam PF08546 http://pfam.xfam.org/family/PF08546 Phobius swissprot:PANE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PANE_ECOLI PhylomeDB P0A9J4 http://phylomedb.org/?seqid=P0A9J4 ProteinModelPortal P0A9J4 http://www.proteinmodelportal.org/query/uniprot/P0A9J4 PubMed 10736170 http://www.ncbi.nlm.nih.gov/pubmed/10736170 PubMed 11123955 http://www.ncbi.nlm.nih.gov/pubmed/11123955 PubMed 11724562 http://www.ncbi.nlm.nih.gov/pubmed/11724562 PubMed 15966718 http://www.ncbi.nlm.nih.gov/pubmed/15966718 PubMed 16042595 http://www.ncbi.nlm.nih.gov/pubmed/16042595 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16884311 http://www.ncbi.nlm.nih.gov/pubmed/16884311 PubMed 17229734 http://www.ncbi.nlm.nih.gov/pubmed/17229734 PubMed 17242510 http://www.ncbi.nlm.nih.gov/pubmed/17242510 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414959 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414959 RefSeq WP_000705865 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000705865 SMR P0A9J4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9J4 STRING 511145.b0425 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0425&targetmode=cogs STRING COG1893 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1893&targetmode=cogs SUPFAM SSF48179 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48179 SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 TIGRFAMs TIGR00745 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00745 UniProtKB PANE_ECOLI http://www.uniprot.org/uniprot/PANE_ECOLI UniProtKB-AC P0A9J4 http://www.uniprot.org/uniprot/P0A9J4 charge swissprot:PANE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PANE_ECOLI eggNOG COG1893 http://eggnogapi.embl.de/nog_data/html/tree/COG1893 eggNOG ENOG4108JZF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108JZF epestfind swissprot:PANE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PANE_ECOLI garnier swissprot:PANE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PANE_ECOLI helixturnhelix swissprot:PANE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PANE_ECOLI hmoment swissprot:PANE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PANE_ECOLI iep swissprot:PANE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PANE_ECOLI inforesidue swissprot:PANE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PANE_ECOLI octanol swissprot:PANE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PANE_ECOLI pepcoil swissprot:PANE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PANE_ECOLI pepdigest swissprot:PANE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PANE_ECOLI pepinfo swissprot:PANE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PANE_ECOLI pepnet swissprot:PANE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PANE_ECOLI pepstats swissprot:PANE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PANE_ECOLI pepwheel swissprot:PANE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PANE_ECOLI pepwindow swissprot:PANE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PANE_ECOLI sigcleave swissprot:PANE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PANE_ECOLI ## Database ID URL or Descriptions # AltName Galactose kinase {ECO:0000255|HAMAP-Rule MF_00246} # BIOPHYSICOCHEMICAL PROPERTIES GAL1_ECOLI Kinetic parameters KM=2.1 mM for D-galactose {ECO 0000269|PubMed 12816414, ECO 0000269|PubMed 14612558}; KM=3.6 mM for 2-deoxy-D-galactose {ECO 0000269|PubMed 12816414, ECO 0000269|PubMed 14612558}; KM=2.9 mM for D-galactosamine {ECO 0000269|PubMed 12816414, ECO 0000269|PubMed 14612558}; KM=2.5 mM for ATP {ECO 0000269|PubMed 12816414, ECO 0000269|PubMed 14612558}; Vmax=1.65 umol/min/mg enzyme with D-galactose as substrate {ECO 0000269|PubMed 12816414, ECO 0000269|PubMed 14612558}; Note=kcat is 108 min(-1), 30 min(-1) and 11.7 min(-1) with D- galactose, 2-deoxy-D-galactose, and D-galactosamine as substrate, respectively.; # BioGrid 4261711 201 # CATALYTIC ACTIVITY GAL1_ECOLI ATP + alpha-D-galactose = ADP + alpha-D- galactose 1-phosphate. {ECO 0000255|HAMAP-Rule MF_00246, ECO 0000269|PubMed 12816414, ECO 0000269|PubMed 14612558, ECO 0000269|PubMed 200486}. # EcoGene EG10363 galK # FUNCTION GAL1_ECOLI Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). To a lesser extent, is also able to phosphorylate 2-deoxy-D-galactose and D-galactosamine. Is not able to use D-galacturonic acid, D- talose, L-altrose, and L-glucose as substrates. {ECO 0000255|HAMAP-Rule MF_00246, ECO 0000269|PubMed 12816414, ECO 0000269|PubMed 14612558, ECO 0000269|PubMed 200486}. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0004335 galactokinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_process GO:0033499 galactose catabolic process via UDP-galactose; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.30.230.10 -; 1. # Gene3D 3.30.70.890 -; 1. # HAMAP MF_00246 Galactokinase # IntAct P0A6T3 4 # InterPro IPR000705 Galactokinase # InterPro IPR006203 GHMP_knse_ATP-bd_CS # InterPro IPR006204 GHMP_kinase_N_dom # InterPro IPR006206 Mevalonate/galactokinase # InterPro IPR013750 GHMP_kinase_C_dom # InterPro IPR014721 Ribosomal_S5_D2-typ_fold_subgr # InterPro IPR019539 GalKase_gal-bd # InterPro IPR019741 Galactokinase_CS # InterPro IPR020568 Ribosomal_S5_D2-typ_fold # InterPro IPR022963 Galactokinase_bac # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00052 Galactose metabolism # KEGG_Pathway ko00520 Amino sugar and nucleotide sugar metabolism # Organism GAL1_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10457 PTHR10457 # PANTHER PTHR10457:SF6 PTHR10457:SF6 # PATHWAY Carbohydrate metabolism; galactose metabolism. {ECO:0000255|HAMAP-Rule MF_00246}. # PATRIC 32116715 VBIEscCol129921_0783 # PIR B23044 KIECGG # PIRSF PIRSF000530 Galactokinase # PRINTS PR00473 GALCTOKINASE # PRINTS PR00959 MEVGALKINASE # PROSITE PS00106 GALACTOKINASE # PROSITE PS00627 GHMP_KINASES_ATP # Pfam PF00288 GHMP_kinases_N # Pfam PF08544 GHMP_kinases_C # Pfam PF10509 GalKase_gal_bdg # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Galactokinase {ECO:0000255|HAMAP-Rule MF_00246} # RefSeq NP_415278 NC_000913.3 # RefSeq WP_000053415 NZ_CP011343.2 # SIMILARITY Belongs to the GHMP kinase family. GalK subfamily. {ECO:0000255|HAMAP-Rule MF_00246}. # SUBCELLULAR LOCATION GAL1_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00246}. # SUPFAM SSF54211 SSF54211 # SUPFAM SSF55060 SSF55060 # TIGRFAMs TIGR00131 gal_kin # eggNOG COG0153 LUCA # eggNOG ENOG4105CRD Bacteria BLAST swissprot:GAL1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GAL1_ECOLI BioCyc ECOL316407:JW0740-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0740-MONOMER BioCyc EcoCyc:GALACTOKIN-MONOMER http://biocyc.org/getid?id=EcoCyc:GALACTOKIN-MONOMER BioCyc MetaCyc:GALACTOKIN-MONOMER http://biocyc.org/getid?id=MetaCyc:GALACTOKIN-MONOMER COG COG0153 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0153 DOI 10.1006/jmbi.1994.1728 http://dx.doi.org/10.1006/jmbi.1994.1728 DOI 10.1016/0014-5793(77)80638-8 http://dx.doi.org/10.1016/0014-5793(77)80638-8 DOI 10.1021/ol034642d http://dx.doi.org/10.1021/ol034642d DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.100.23.13184 http://dx.doi.org/10.1073/pnas.100.23.13184 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/13.6.1841 http://dx.doi.org/10.1093/nar/13.6.1841 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.6026/97320630005422 http://dx.doi.org/10.6026/97320630005422 EC_number EC:2.7.1.6 {ECO:0000255|HAMAP-Rule:MF_00246} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.6 {ECO:0000255|HAMAP-Rule:MF_00246} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U13636 http://www.ebi.ac.uk/ena/data/view/U13636 EMBL X02306 http://www.ebi.ac.uk/ena/data/view/X02306 ENZYME 2.7.1.6 {ECO:0000255|HAMAP-Rule:MF_00246} http://enzyme.expasy.org/EC/2.7.1.6 {ECO:0000255|HAMAP-Rule:MF_00246} EchoBASE EB0358 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0358 EcoGene EG10363 http://www.ecogene.org/geneInfo.php?eg_id=EG10363 EnsemblBacteria AAC73844 http://www.ensemblgenomes.org/id/AAC73844 EnsemblBacteria AAC73844 http://www.ensemblgenomes.org/id/AAC73844 EnsemblBacteria BAA35419 http://www.ensemblgenomes.org/id/BAA35419 EnsemblBacteria BAA35419 http://www.ensemblgenomes.org/id/BAA35419 EnsemblBacteria BAA35419 http://www.ensemblgenomes.org/id/BAA35419 EnsemblBacteria b0757 http://www.ensemblgenomes.org/id/b0757 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0004335 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004335 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0033499 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033499 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.30.230.10 http://www.cathdb.info/version/latest/superfamily/3.30.230.10 Gene3D 3.30.70.890 http://www.cathdb.info/version/latest/superfamily/3.30.70.890 GeneID 945358 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945358 HAMAP MF_00246 http://hamap.expasy.org/unirule/MF_00246 HOGENOM HOG000241100 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000241100&db=HOGENOM6 InParanoid P0A6T3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6T3 IntAct P0A6T3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6T3* IntEnz 2.7.1.6 {ECO:0000255|HAMAP-Rule:MF_00246} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.6 {ECO:0000255|HAMAP-Rule:MF_00246} InterPro IPR000705 http://www.ebi.ac.uk/interpro/entry/IPR000705 InterPro IPR006203 http://www.ebi.ac.uk/interpro/entry/IPR006203 InterPro IPR006204 http://www.ebi.ac.uk/interpro/entry/IPR006204 InterPro IPR006206 http://www.ebi.ac.uk/interpro/entry/IPR006206 InterPro IPR013750 http://www.ebi.ac.uk/interpro/entry/IPR013750 InterPro IPR014721 http://www.ebi.ac.uk/interpro/entry/IPR014721 InterPro IPR019539 http://www.ebi.ac.uk/interpro/entry/IPR019539 InterPro IPR019741 http://www.ebi.ac.uk/interpro/entry/IPR019741 InterPro IPR020568 http://www.ebi.ac.uk/interpro/entry/IPR020568 InterPro IPR022963 http://www.ebi.ac.uk/interpro/entry/IPR022963 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0740 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0740 KEGG_Gene eco:b0757 http://www.genome.jp/dbget-bin/www_bget?eco:b0757 KEGG_Orthology KO:K00849 http://www.genome.jp/dbget-bin/www_bget?KO:K00849 KEGG_Pathway ko00052 http://www.genome.jp/kegg-bin/show_pathway?ko00052 KEGG_Pathway ko00520 http://www.genome.jp/kegg-bin/show_pathway?ko00520 KEGG_Reaction rn:R01092 http://www.genome.jp/dbget-bin/www_bget?rn:R01092 OMA VMPCAIN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VMPCAIN PANTHER PTHR10457 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10457 PANTHER PTHR10457:SF6 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10457:SF6 PRINTS PR00473 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00473 PRINTS PR00959 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00959 PROSITE PS00106 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00106 PROSITE PS00627 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00627 PSORT swissprot:GAL1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GAL1_ECOLI PSORT-B swissprot:GAL1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GAL1_ECOLI PSORT2 swissprot:GAL1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GAL1_ECOLI Pfam PF00288 http://pfam.xfam.org/family/PF00288 Pfam PF08544 http://pfam.xfam.org/family/PF08544 Pfam PF10509 http://pfam.xfam.org/family/PF10509 Phobius swissprot:GAL1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GAL1_ECOLI PhylomeDB P0A6T3 http://phylomedb.org/?seqid=P0A6T3 ProteinModelPortal P0A6T3 http://www.proteinmodelportal.org/query/uniprot/P0A6T3 PubMed 12816414 http://www.ncbi.nlm.nih.gov/pubmed/12816414 PubMed 14612558 http://www.ncbi.nlm.nih.gov/pubmed/14612558 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 200486 http://www.ncbi.nlm.nih.gov/pubmed/200486 PubMed 21423888 http://www.ncbi.nlm.nih.gov/pubmed/21423888 PubMed 3158881 http://www.ncbi.nlm.nih.gov/pubmed/3158881 PubMed 7966338 http://www.ncbi.nlm.nih.gov/pubmed/7966338 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415278 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415278 RefSeq WP_000053415 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000053415 SMR P0A6T3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6T3 STRING 511145.b0757 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0757&targetmode=cogs STRING COG0153 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0153&targetmode=cogs SUPFAM SSF54211 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54211 SUPFAM SSF55060 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55060 TIGRFAMs TIGR00131 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00131 UniProtKB GAL1_ECOLI http://www.uniprot.org/uniprot/GAL1_ECOLI UniProtKB-AC P0A6T3 http://www.uniprot.org/uniprot/P0A6T3 charge swissprot:GAL1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GAL1_ECOLI eggNOG COG0153 http://eggnogapi.embl.de/nog_data/html/tree/COG0153 eggNOG ENOG4105CRD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CRD epestfind swissprot:GAL1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GAL1_ECOLI garnier swissprot:GAL1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GAL1_ECOLI helixturnhelix swissprot:GAL1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GAL1_ECOLI hmoment swissprot:GAL1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GAL1_ECOLI iep swissprot:GAL1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GAL1_ECOLI inforesidue swissprot:GAL1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GAL1_ECOLI octanol swissprot:GAL1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GAL1_ECOLI pepcoil swissprot:GAL1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GAL1_ECOLI pepdigest swissprot:GAL1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GAL1_ECOLI pepinfo swissprot:GAL1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GAL1_ECOLI pepnet swissprot:GAL1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GAL1_ECOLI pepstats swissprot:GAL1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GAL1_ECOLI pepwheel swissprot:GAL1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GAL1_ECOLI pepwindow swissprot:GAL1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GAL1_ECOLI sigcleave swissprot:GAL1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GAL1_ECOLI ## Database ID URL or Descriptions # BioGrid 4260827 7 # EcoGene EG12472 yjeJ # IntAct P39279 10 # InterPro IPR031810 YjeJ-like # Organism YJEJ_ECOLI Escherichia coli (strain K12) # PATRIC 32123859 VBIEscCol129921_4277 # PIR S56373 S56373 # Pfam PF15922 YjeJ # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJEJ_ECOLI Uncharacterized protein YjeJ # RefSeq NP_418569 NC_000913.3 # RefSeq WP_001008040 NZ_LN832404.1 # eggNOG ENOG4105MTB Bacteria # eggNOG ENOG4111VQX LUCA BLAST swissprot:YJEJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJEJ_ECOLI BioCyc ECOL316407:JW4105-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4105-MONOMER BioCyc EcoCyc:G7835-MONOMER http://biocyc.org/getid?id=EcoCyc:G7835-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2365 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2365 EcoGene EG12472 http://www.ecogene.org/geneInfo.php?eg_id=EG12472 EnsemblBacteria AAC77105 http://www.ensemblgenomes.org/id/AAC77105 EnsemblBacteria AAC77105 http://www.ensemblgenomes.org/id/AAC77105 EnsemblBacteria BAE78147 http://www.ensemblgenomes.org/id/BAE78147 EnsemblBacteria BAE78147 http://www.ensemblgenomes.org/id/BAE78147 EnsemblBacteria BAE78147 http://www.ensemblgenomes.org/id/BAE78147 EnsemblBacteria b4145 http://www.ensemblgenomes.org/id/b4145 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 948663 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948663 HOGENOM HOG000127274 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000127274&db=HOGENOM6 IntAct P39279 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39279* InterPro IPR031810 http://www.ebi.ac.uk/interpro/entry/IPR031810 KEGG_Gene ecj:JW4105 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4105 KEGG_Gene eco:b4145 http://www.genome.jp/dbget-bin/www_bget?eco:b4145 OMA GTFIGFN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GTFIGFN PSORT swissprot:YJEJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJEJ_ECOLI PSORT-B swissprot:YJEJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJEJ_ECOLI PSORT2 swissprot:YJEJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJEJ_ECOLI Pfam PF15922 http://pfam.xfam.org/family/PF15922 Phobius swissprot:YJEJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJEJ_ECOLI ProteinModelPortal P39279 http://www.proteinmodelportal.org/query/uniprot/P39279 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418569 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418569 RefSeq WP_001008040 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001008040 STRING 511145.b4145 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4145&targetmode=cogs UniProtKB YJEJ_ECOLI http://www.uniprot.org/uniprot/YJEJ_ECOLI UniProtKB-AC P39279 http://www.uniprot.org/uniprot/P39279 charge swissprot:YJEJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJEJ_ECOLI eggNOG ENOG4105MTB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105MTB eggNOG ENOG4111VQX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111VQX epestfind swissprot:YJEJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJEJ_ECOLI garnier swissprot:YJEJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJEJ_ECOLI helixturnhelix swissprot:YJEJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJEJ_ECOLI hmoment swissprot:YJEJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJEJ_ECOLI iep swissprot:YJEJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJEJ_ECOLI inforesidue swissprot:YJEJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJEJ_ECOLI octanol swissprot:YJEJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJEJ_ECOLI pepcoil swissprot:YJEJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJEJ_ECOLI pepdigest swissprot:YJEJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJEJ_ECOLI pepinfo swissprot:YJEJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJEJ_ECOLI pepnet swissprot:YJEJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJEJ_ECOLI pepstats swissprot:YJEJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJEJ_ECOLI pepwheel swissprot:YJEJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJEJ_ECOLI pepwindow swissprot:YJEJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJEJ_ECOLI sigcleave swissprot:YJEJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJEJ_ECOLI ## Database ID URL or Descriptions # AltName PANC_ECOLI Pantoate--beta-alanine ligase # AltName PANC_ECOLI Pantoate-activating enzyme # BIOPHYSICOCHEMICAL PROPERTIES PANC_ECOLI Kinetic parameters KM=63 uM for pantoate {ECO 0000269|PubMed 357689}; KM=100 uM for ATP {ECO 0000269|PubMed 357689}; KM=150 uM for beta-alanine {ECO 0000269|PubMed 357689}; KM=2000 uM for magnesium {ECO 0000269|PubMed 357689}; KM=5500 uM for manganese {ECO 0000269|PubMed 357689}; pH dependence Optimum pH is 10. Stable from pH 5.0 to 11.0. {ECO 0000269|PubMed 357689}; Temperature dependence Optimum temperature is 30 degrees Celsius. Stable up to 37 degrees Celsius and loses activity almost completely when incubated at 60 degrees Celsius for 10 minutes. {ECO 0000269|PubMed 357689}; # BRENDA 6.3.2 2026 # BioGrid 4261166 135 # CATALYTIC ACTIVITY PANC_ECOLI ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate. # CDD cd00560 PanC # ENZYME REGULATION Activation requires a combination of a divalent cation, magnesium or manganese, and a monovalent cation, potassium or ammonium. Above the optimum concentration for activation, magnesium and manganese are rather inhibitory. Also activated by 2-mercaptoethanol, dithiothreitol, cysteine and glutathione. Inhibited by divalent cations (mercury, cobalt, zinc, copper, silver), chelating agents (EDTA, EGTA and o-phenanthroline), and analogs of beta-alanine (taurine, gamma-aminobutyrate, gamma- amino-beta-hydroxybutyrate). {ECO:0000269|PubMed 357689}. # EcoGene EG11746 panC # FUNCTION PANC_ECOLI Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. {ECO 0000269|PubMed 357689}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0004592 pantoate-beta-alanine ligase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0042802 identical protein binding; IPI:IntAct. # GO_process GO:0033317 pantothenate biosynthetic process from valine; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.620 -; 1. # HAMAP MF_00158 PanC # INTERACTION PANC_ECOLI Self; NbExp=5; IntAct=EBI-545354, EBI-545354; P65556 yfcD; NbExp=5; IntAct=EBI-545354, EBI-545346; # IntAct P31663 11 # InterPro IPR003721 Pantoate_ligase # InterPro IPR004821 Cyt_trans-like # InterPro IPR014729 Rossmann-like_a/b/a_fold # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00410 beta-Alanine metabolism # KEGG_Pathway ko00770 Pantothenate and CoA biosynthesis # MASS SPECTROMETRY Mass=31601.2; Mass_error=3.4; Method=Electrospray; Range=1-283; Evidence={ECO:0000269|PubMed 11377204}; # MISCELLANEOUS PANC_ECOLI The reaction proceeds by a bi uni uni bi ping pong mechanism. # Organism PANC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21299:SF1 PTHR21299:SF1 # PATHWAY Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine step 1/1. # PATRIC 32115371 VBIEscCol129921_0137 # PDB 1IHO X-ray; 1.70 A; A/B=1-283 # PDB 3GUZ X-ray; 1.67 A; A/B=1-176 # PIR E64736 E64736 # Pfam PF02569 Pantoate_ligase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PANC_ECOLI Pantothenate synthetase # RefSeq NP_414675 NC_000913.3 # RefSeq WP_000905383 NZ_LN832404.1 # SIMILARITY Belongs to the pantothenate synthetase family. {ECO 0000305}. # SUBCELLULAR LOCATION PANC_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 11377204}. # TIGRFAMs TIGR00018 panC # TIGRFAMs TIGR00125 cyt_tran_rel # UniPathway UPA00028 UER00005 # eggNOG COG0414 LUCA # eggNOG ENOG4107R03 Bacteria BLAST swissprot:PANC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PANC_ECOLI BioCyc ECOL316407:JW0129-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0129-MONOMER BioCyc EcoCyc:PANTOATE-BETA-ALANINE-LIG-MONOMER http://biocyc.org/getid?id=EcoCyc:PANTOATE-BETA-ALANINE-LIG-MONOMER BioCyc MetaCyc:PANTOATE-BETA-ALANINE-LIG-MONOMER http://biocyc.org/getid?id=MetaCyc:PANTOATE-BETA-ALANINE-LIG-MONOMER COG COG0414 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0414 DIP DIP-10437N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10437N DOI 10.1016/0378-1097(96)00321-7 http://dx.doi.org/10.1016/0378-1097(96)00321-7 DOI 10.1016/S0969-2126(01)00604-9 http://dx.doi.org/10.1016/S0969-2126(01)00604-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.3.2.1 http://www.genome.jp/dbget-bin/www_bget?EC:6.3.2.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L17086 http://www.ebi.ac.uk/ena/data/view/L17086 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 6.3.2.1 http://enzyme.expasy.org/EC/6.3.2.1 EchoBASE EB1696 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1696 EcoGene EG11746 http://www.ecogene.org/geneInfo.php?eg_id=EG11746 EnsemblBacteria AAC73244 http://www.ensemblgenomes.org/id/AAC73244 EnsemblBacteria AAC73244 http://www.ensemblgenomes.org/id/AAC73244 EnsemblBacteria BAE76042 http://www.ensemblgenomes.org/id/BAE76042 EnsemblBacteria BAE76042 http://www.ensemblgenomes.org/id/BAE76042 EnsemblBacteria BAE76042 http://www.ensemblgenomes.org/id/BAE76042 EnsemblBacteria b0133 http://www.ensemblgenomes.org/id/b0133 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004592 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0033317 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033317 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 GeneID 944958 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944958 HAMAP MF_00158 http://hamap.expasy.org/unirule/MF_00158 HOGENOM HOG000175517 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000175517&db=HOGENOM6 InParanoid P31663 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31663 IntAct P31663 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31663* IntEnz 6.3.2.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.2.1 InterPro IPR003721 http://www.ebi.ac.uk/interpro/entry/IPR003721 InterPro IPR004821 http://www.ebi.ac.uk/interpro/entry/IPR004821 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0129 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0129 KEGG_Gene eco:b0133 http://www.genome.jp/dbget-bin/www_bget?eco:b0133 KEGG_Orthology KO:K01918 http://www.genome.jp/dbget-bin/www_bget?KO:K01918 KEGG_Pathway ko00410 http://www.genome.jp/kegg-bin/show_pathway?ko00410 KEGG_Pathway ko00770 http://www.genome.jp/kegg-bin/show_pathway?ko00770 KEGG_Reaction rn:R02473 http://www.genome.jp/dbget-bin/www_bget?rn:R02473 MINT MINT-1249237 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1249237 OMA ENVDCIF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ENVDCIF PANTHER PTHR21299:SF1 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21299:SF1 PDB 1IHO http://www.ebi.ac.uk/pdbe-srv/view/entry/1IHO PDB 3GUZ http://www.ebi.ac.uk/pdbe-srv/view/entry/3GUZ PDBsum 1IHO http://www.ebi.ac.uk/pdbsum/1IHO PDBsum 3GUZ http://www.ebi.ac.uk/pdbsum/3GUZ PSORT swissprot:PANC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PANC_ECOLI PSORT-B swissprot:PANC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PANC_ECOLI PSORT2 swissprot:PANC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PANC_ECOLI Pfam PF02569 http://pfam.xfam.org/family/PF02569 Phobius swissprot:PANC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PANC_ECOLI PhylomeDB P31663 http://phylomedb.org/?seqid=P31663 ProteinModelPortal P31663 http://www.proteinmodelportal.org/query/uniprot/P31663 PubMed 11377204 http://www.ncbi.nlm.nih.gov/pubmed/11377204 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 357689 http://www.ncbi.nlm.nih.gov/pubmed/357689 PubMed 8837478 http://www.ncbi.nlm.nih.gov/pubmed/8837478 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414675 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414675 RefSeq WP_000905383 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000905383 SMR P31663 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31663 STRING 511145.b0133 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0133&targetmode=cogs STRING COG0414 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0414&targetmode=cogs SWISS-2DPAGE P31663 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P31663 TIGRFAMs TIGR00018 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00018 TIGRFAMs TIGR00125 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00125 UniProtKB PANC_ECOLI http://www.uniprot.org/uniprot/PANC_ECOLI UniProtKB-AC P31663 http://www.uniprot.org/uniprot/P31663 charge swissprot:PANC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PANC_ECOLI eggNOG COG0414 http://eggnogapi.embl.de/nog_data/html/tree/COG0414 eggNOG ENOG4107R03 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107R03 epestfind swissprot:PANC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PANC_ECOLI garnier swissprot:PANC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PANC_ECOLI helixturnhelix swissprot:PANC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PANC_ECOLI hmoment swissprot:PANC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PANC_ECOLI iep swissprot:PANC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PANC_ECOLI inforesidue swissprot:PANC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PANC_ECOLI octanol swissprot:PANC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PANC_ECOLI pepcoil swissprot:PANC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PANC_ECOLI pepdigest swissprot:PANC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PANC_ECOLI pepinfo swissprot:PANC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PANC_ECOLI pepnet swissprot:PANC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PANC_ECOLI pepstats swissprot:PANC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PANC_ECOLI pepwheel swissprot:PANC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PANC_ECOLI pepwindow swissprot:PANC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PANC_ECOLI sigcleave swissprot:PANC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PANC_ECOLI ## Database ID URL or Descriptions # BioGrid 4262831 128 # CDD cd06174 MFS # EcoGene EG13679 ybjJ # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0022891 substrate-specific transmembrane transporter activity; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # Organism YBJJ_ECOLI Escherichia coli (strain K12) # PATRIC 32116895 VBIEscCol129921_0873 # PIR E64822 E64822 # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBJJ_ECOLI Inner membrane protein YbjJ # RefSeq NP_415366 NC_000913.3 # RefSeq WP_000217859 NZ_LN832404.1 # SUBCELLULAR LOCATION YBJJ_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.60 the major facilitator superfamily (mfs) # eggNOG ENOG4106UW1 Bacteria # eggNOG ENOG410XRK1 LUCA BLAST swissprot:YBJJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBJJ_ECOLI BioCyc ECOL316407:JW0829-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0829-MONOMER BioCyc EcoCyc:G6443-MONOMER http://biocyc.org/getid?id=EcoCyc:G6443-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3443 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3443 EcoGene EG13679 http://www.ecogene.org/geneInfo.php?eg_id=EG13679 EnsemblBacteria AAC73932 http://www.ensemblgenomes.org/id/AAC73932 EnsemblBacteria AAC73932 http://www.ensemblgenomes.org/id/AAC73932 EnsemblBacteria BAA35549 http://www.ensemblgenomes.org/id/BAA35549 EnsemblBacteria BAA35549 http://www.ensemblgenomes.org/id/BAA35549 EnsemblBacteria BAA35549 http://www.ensemblgenomes.org/id/BAA35549 EnsemblBacteria b0845 http://www.ensemblgenomes.org/id/b0845 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0022891 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022891 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GeneID 945471 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945471 HOGENOM HOG000249005 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000249005&db=HOGENOM6 InParanoid P75810 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75810 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Gene ecj:JW0829 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0829 KEGG_Gene eco:b0845 http://www.genome.jp/dbget-bin/www_bget?eco:b0845 OMA CHAIAFA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CHAIAFA PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:YBJJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBJJ_ECOLI PSORT-B swissprot:YBJJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBJJ_ECOLI PSORT2 swissprot:YBJJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBJJ_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:YBJJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBJJ_ECOLI PhylomeDB P75810 http://phylomedb.org/?seqid=P75810 ProteinModelPortal P75810 http://www.proteinmodelportal.org/query/uniprot/P75810 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415366 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415366 RefSeq WP_000217859 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000217859 STRING 511145.b0845 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0845&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.60 http://www.tcdb.org/search/result.php?tc=2.A.1.60 UniProtKB YBJJ_ECOLI http://www.uniprot.org/uniprot/YBJJ_ECOLI UniProtKB-AC P75810 http://www.uniprot.org/uniprot/P75810 charge swissprot:YBJJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBJJ_ECOLI eggNOG ENOG4106UW1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106UW1 eggNOG ENOG410XRK1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRK1 epestfind swissprot:YBJJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBJJ_ECOLI garnier swissprot:YBJJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBJJ_ECOLI helixturnhelix swissprot:YBJJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBJJ_ECOLI hmoment swissprot:YBJJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBJJ_ECOLI iep swissprot:YBJJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBJJ_ECOLI inforesidue swissprot:YBJJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBJJ_ECOLI octanol swissprot:YBJJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBJJ_ECOLI pepcoil swissprot:YBJJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBJJ_ECOLI pepdigest swissprot:YBJJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBJJ_ECOLI pepinfo swissprot:YBJJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBJJ_ECOLI pepnet swissprot:YBJJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBJJ_ECOLI pepstats swissprot:YBJJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBJJ_ECOLI pepwheel swissprot:YBJJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBJJ_ECOLI pepwindow swissprot:YBJJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBJJ_ECOLI sigcleave swissprot:YBJJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBJJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4262517 2 # EcoGene EG11390 uspA # FUNCTION USPA_ECOLI Required for resistance to DNA-damaging agents. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_process GO:0006950 response to stress; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_process GO:0006950 response to stress # Gene3D 3.40.50.620 -; 1. # INDUCTION USPA_ECOLI During growth inhibition caused by the exhaustion of any of a variety of nutrients (carbon, nitrogen, phosphate, sulfate, required amino acid) or by the presence of a variety of toxic agents. Positively regulated by guanosine 3',5'-bisphosphate (ppGpp) and by a RecA/FtsK-dependent regulatory pathway. Negatively regulated by FadR. Also regulated by CspC and CspE. # INTERACTION USPA_ECOLI Self; NbExp=2; IntAct=EBI-552843, EBI-552843; # IntAct P0AED0 9 # InterPro IPR006015 Universal_stress_UspA # InterPro IPR006016 UspA # InterPro IPR014729 Rossmann-like_a/b/a_fold # Organism USPA_ECOLI Escherichia coli (strain K12) # PATRIC 32122440 VBIEscCol129921_3597 # PIR S47715 S47715 # PIRSF PIRSF006276 UspA # PTM USPA_ECOLI Phosphorylated on serine or threonine in response to stasis. {ECO 0000269|PubMed 9405142}. # Pfam PF00582 Usp # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName USPA_ECOLI Universal stress protein A # RefSeq NP_417952 NC_000913.3 # RefSeq WP_000323571 NZ_LN832404.1 # SIMILARITY Belongs to the universal stress protein A family. {ECO 0000305}. # SUBCELLULAR LOCATION USPA_ECOLI Cytoplasm. # SUBUNIT Homodimer. {ECO 0000250}. # eggNOG COG0589 LUCA BLAST swissprot:USPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:USPA_ECOLI BioCyc ECOL316407:JW3462-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3462-MONOMER BioCyc EcoCyc:EG11390-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11390-MONOMER COG COG0589 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0589 DIP DIP-36230N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36230N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1997.1397 http://dx.doi.org/10.1006/jmbi.1997.1397 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2000.01714.x http://dx.doi.org/10.1046/j.1365-2958.2000.01714.x DOI 10.1046/j.1365-2958.2000.01979.x http://dx.doi.org/10.1046/j.1365-2958.2000.01979.x DOI 10.1073/pnas.90.11.5011 http://dx.doi.org/10.1073/pnas.90.11.5011 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1111/j.1365-2958.1992.tb01774.x http://dx.doi.org/10.1111/j.1365-2958.1992.tb01774.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.183.4.1205-1214.2001 http://dx.doi.org/10.1128/JB.183.4.1205-1214.2001 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X67639 http://www.ebi.ac.uk/ena/data/view/X67639 EchoBASE EB1363 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1363 EcoGene EG11390 http://www.ecogene.org/geneInfo.php?eg_id=EG11390 EnsemblBacteria AAC76520 http://www.ensemblgenomes.org/id/AAC76520 EnsemblBacteria AAC76520 http://www.ensemblgenomes.org/id/AAC76520 EnsemblBacteria BAE77799 http://www.ensemblgenomes.org/id/BAE77799 EnsemblBacteria BAE77799 http://www.ensemblgenomes.org/id/BAE77799 EnsemblBacteria BAE77799 http://www.ensemblgenomes.org/id/BAE77799 EnsemblBacteria b3495 http://www.ensemblgenomes.org/id/b3495 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 GeneID 948007 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948007 HOGENOM HOG000238899 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000238899&db=HOGENOM6 InParanoid P0AED0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AED0 IntAct P0AED0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AED0* InterPro IPR006015 http://www.ebi.ac.uk/interpro/entry/IPR006015 InterPro IPR006016 http://www.ebi.ac.uk/interpro/entry/IPR006016 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 KEGG_Gene ecj:JW3462 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3462 KEGG_Gene eco:b3495 http://www.genome.jp/dbget-bin/www_bget?eco:b3495 KEGG_Orthology KO:K06149 http://www.genome.jp/dbget-bin/www_bget?KO:K06149 MINT MINT-1291607 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1291607 OMA SARQLMN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SARQLMN PSORT swissprot:USPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:USPA_ECOLI PSORT-B swissprot:USPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:USPA_ECOLI PSORT2 swissprot:USPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:USPA_ECOLI Pfam PF00582 http://pfam.xfam.org/family/PF00582 Phobius swissprot:USPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:USPA_ECOLI PhylomeDB P0AED0 http://phylomedb.org/?seqid=P0AED0 ProteinModelPortal P0AED0 http://www.proteinmodelportal.org/query/uniprot/P0AED0 PubMed 10652104 http://www.ncbi.nlm.nih.gov/pubmed/10652104 PubMed 10931298 http://www.ncbi.nlm.nih.gov/pubmed/10931298 PubMed 11157932 http://www.ncbi.nlm.nih.gov/pubmed/11157932 PubMed 1453957 http://www.ncbi.nlm.nih.gov/pubmed/1453957 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 8506346 http://www.ncbi.nlm.nih.gov/pubmed/8506346 PubMed 8932299 http://www.ncbi.nlm.nih.gov/pubmed/8932299 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9405142 http://www.ncbi.nlm.nih.gov/pubmed/9405142 RefSeq NP_417952 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417952 RefSeq WP_000323571 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000323571 SMR P0AED0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AED0 STRING 511145.b3495 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3495&targetmode=cogs STRING COG0589 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0589&targetmode=cogs SWISS-2DPAGE P0AED0 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AED0 UniProtKB USPA_ECOLI http://www.uniprot.org/uniprot/USPA_ECOLI UniProtKB-AC P0AED0 http://www.uniprot.org/uniprot/P0AED0 charge swissprot:USPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:USPA_ECOLI eggNOG COG0589 http://eggnogapi.embl.de/nog_data/html/tree/COG0589 epestfind swissprot:USPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:USPA_ECOLI garnier swissprot:USPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:USPA_ECOLI helixturnhelix swissprot:USPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:USPA_ECOLI hmoment swissprot:USPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:USPA_ECOLI iep swissprot:USPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:USPA_ECOLI inforesidue swissprot:USPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:USPA_ECOLI octanol swissprot:USPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:USPA_ECOLI pepcoil swissprot:USPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:USPA_ECOLI pepdigest swissprot:USPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:USPA_ECOLI pepinfo swissprot:USPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:USPA_ECOLI pepnet swissprot:USPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:USPA_ECOLI pepstats swissprot:USPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:USPA_ECOLI pepwheel swissprot:USPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:USPA_ECOLI pepwindow swissprot:USPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:USPA_ECOLI sigcleave swissprot:USPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:USPA_ECOLI ## Database ID URL or Descriptions # AltName DACB_ECOLI D-alanyl-D-alanine endopeptidase # AltName DACB_ECOLI Penicillin-binding protein 4 # BRENDA 3.4.16 2165 # BRENDA 3.4.17.14 2026 # BioGrid 4262437 320 # CATALYTIC ACTIVITY Preferential cleavage (Ac)(2)-L-Lys-D-Ala-|- D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine. # DrugBank DB00303 Ertapenem # DrugBank DB00417 Phenoxymethylpenicillin # DrugBank DB00760 Meropenem # DrugBank DB01328 Cefonicid # DrugBank DB01329 Cefoperazone # DrugBank DB01331 Cefoxitin # DrugBank DB04570 Latamoxef # EcoGene EG10202 dacB # FUNCTION DACB_ECOLI Not involved in transpeptidation but exclusively catalyzes a DD-carboxypeptidase and DD-endopeptidase reaction. {ECO 0000269|PubMed 2046551}. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IMP:EcoliWiki. # GO_function GO:0004175 endopeptidase activity; IDA:EcoCyc. # GO_function GO:0004180 carboxypeptidase activity; IMP:EcoCyc. # GO_function GO:0008658 penicillin binding; IDA:EcoCyc. # GO_function GO:0009002 serine-type D-Ala-D-Ala carboxypeptidase activity; IMP:EcoliWiki. # GO_process GO:0000270 peptidoglycan metabolic process; IDA:EcoCyc. # GO_process GO:0008360 regulation of cell shape; IGI:EcoCyc. # GO_process GO:0009252 peptidoglycan biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0009253 peptidoglycan catabolic process; IDA:EcoCyc. # GO_process GO:0009254 peptidoglycan turnover; IDA:EcoCyc. # GO_process GO:0016998 cell wall macromolecule catabolic process; IDA:EcoCyc. # GO_process GO:0043093 FtsZ-dependent cytokinesis; IGI:EcoCyc. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GO_process GO:0071555 cell wall organization; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 3.40.710.10 -; 1. # INTERACTION DACB_ECOLI P0A6E4 argG; NbExp=2; IntAct=EBI-1131834, EBI-1120296; # InterPro IPR000667 Peptidase_S13 # InterPro IPR012338 Beta-lactam/transpept-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # KEGG_Pathway ko00550 Peptidoglycan biosynthesis # MISCELLANEOUS In E.coli there are three murein endopeptidases two are penicillin sensitive (DacB and PbpG), the other (MepA) not. # Organism DACB_ECOLI Escherichia coli (strain K12) # PATHWAY DACB_ECOLI Cell wall biogenesis; peptidoglycan biosynthesis. # PATRIC 32121782 VBIEscCol129921_3275 # PDB 2EX2 X-ray; 1.55 A; A=21-477 # PDB 2EX6 X-ray; 1.60 A; A=21-477 # PDB 2EX8 X-ray; 1.60 A; A=21-477 # PDB 2EX9 X-ray; 1.65 A; A=21-477 # PDB 2EXA X-ray; 1.70 A; A=21-477 # PDB 2EXB X-ray; 1.75 A; A=21-477 # PIR A54535 A54535 # PRINTS PR00922 DADACBPTASE3 # Pfam PF02113 Peptidase_S13 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DACB_ECOLI D-alanyl-D-alanine carboxypeptidase DacB # RefSeq NP_417649 NC_000913.3 # RefSeq WP_001212619 NZ_CP014272.1 # SIMILARITY Belongs to the peptidase S13 family. {ECO 0000305}. # SUBCELLULAR LOCATION DACB_ECOLI Periplasm {ECO 0000305}. # SUPFAM SSF56601 SSF56601 # TIGRFAMs TIGR00666 PBP4 # eggNOG COG2027 LUCA # eggNOG ENOG4106HRJ Bacteria BLAST swissprot:DACB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DACB_ECOLI BioCyc ECOL316407:JW3149-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3149-MONOMER BioCyc EcoCyc:EG10202-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10202-MONOMER BioCyc MetaCyc:EG10202-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10202-MONOMER COG COG2027 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2027 DOI 10.1016/0378-1097(91)90160-C http://dx.doi.org/10.1016/0378-1097(91)90160-C DOI 10.1021/bi051533t http://dx.doi.org/10.1021/bi051533t DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1991.tb00739.x http://dx.doi.org/10.1111/j.1365-2958.1991.tb00739.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB00303 http://www.drugbank.ca/drugs/DB00303 DrugBank DB00417 http://www.drugbank.ca/drugs/DB00417 DrugBank DB00760 http://www.drugbank.ca/drugs/DB00760 DrugBank DB01328 http://www.drugbank.ca/drugs/DB01328 DrugBank DB01329 http://www.drugbank.ca/drugs/DB01329 DrugBank DB01331 http://www.drugbank.ca/drugs/DB01331 DrugBank DB04570 http://www.drugbank.ca/drugs/DB04570 EC_number EC:3.4.16.4 http://www.genome.jp/dbget-bin/www_bget?EC:3.4.16.4 EC_number EC:3.4.21.- http://www.genome.jp/dbget-bin/www_bget?EC:3.4.21.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U01376 http://www.ebi.ac.uk/ena/data/view/U01376 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X59460 http://www.ebi.ac.uk/ena/data/view/X59460 EMBL X60038 http://www.ebi.ac.uk/ena/data/view/X60038 ENZYME 3.4.16.4 http://enzyme.expasy.org/EC/3.4.16.4 ENZYME 3.4.21.- http://enzyme.expasy.org/EC/3.4.21.- EchoBASE EB0198 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0198 EcoGene EG10202 http://www.ecogene.org/geneInfo.php?eg_id=EG10202 EnsemblBacteria AAC76214 http://www.ensemblgenomes.org/id/AAC76214 EnsemblBacteria AAC76214 http://www.ensemblgenomes.org/id/AAC76214 EnsemblBacteria BAE77226 http://www.ensemblgenomes.org/id/BAE77226 EnsemblBacteria BAE77226 http://www.ensemblgenomes.org/id/BAE77226 EnsemblBacteria BAE77226 http://www.ensemblgenomes.org/id/BAE77226 EnsemblBacteria b3182 http://www.ensemblgenomes.org/id/b3182 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0004175 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004175 GO_function GO:0004180 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004180 GO_function GO:0008658 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008658 GO_function GO:0009002 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009002 GO_process GO:0000270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000270 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0009252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009252 GO_process GO:0009253 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009253 GO_process GO:0009254 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009254 GO_process GO:0016998 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016998 GO_process GO:0043093 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043093 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 3.40.710.10 http://www.cathdb.info/version/latest/superfamily/3.40.710.10 GeneID 947693 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947693 HOGENOM HOG000279266 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000279266&db=HOGENOM6 InParanoid P24228 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P24228 IntAct P24228 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P24228* IntEnz 3.4.16.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.16.4 IntEnz 3.4.21 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.21 InterPro IPR000667 http://www.ebi.ac.uk/interpro/entry/IPR000667 InterPro IPR012338 http://www.ebi.ac.uk/interpro/entry/IPR012338 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW3149 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3149 KEGG_Gene eco:b3182 http://www.genome.jp/dbget-bin/www_bget?eco:b3182 KEGG_Orthology KO:K07259 http://www.genome.jp/dbget-bin/www_bget?KO:K07259 KEGG_Pathway ko00550 http://www.genome.jp/kegg-bin/show_pathway?ko00550 OMA AHSKPMK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AHSKPMK PDB 2EX2 http://www.ebi.ac.uk/pdbe-srv/view/entry/2EX2 PDB 2EX6 http://www.ebi.ac.uk/pdbe-srv/view/entry/2EX6 PDB 2EX8 http://www.ebi.ac.uk/pdbe-srv/view/entry/2EX8 PDB 2EX9 http://www.ebi.ac.uk/pdbe-srv/view/entry/2EX9 PDB 2EXA http://www.ebi.ac.uk/pdbe-srv/view/entry/2EXA PDB 2EXB http://www.ebi.ac.uk/pdbe-srv/view/entry/2EXB PDBsum 2EX2 http://www.ebi.ac.uk/pdbsum/2EX2 PDBsum 2EX6 http://www.ebi.ac.uk/pdbsum/2EX6 PDBsum 2EX8 http://www.ebi.ac.uk/pdbsum/2EX8 PDBsum 2EX9 http://www.ebi.ac.uk/pdbsum/2EX9 PDBsum 2EXA http://www.ebi.ac.uk/pdbsum/2EXA PDBsum 2EXB http://www.ebi.ac.uk/pdbsum/2EXB PRINTS PR00922 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00922 PSORT swissprot:DACB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DACB_ECOLI PSORT-B swissprot:DACB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DACB_ECOLI PSORT2 swissprot:DACB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DACB_ECOLI Pfam PF02113 http://pfam.xfam.org/family/PF02113 Phobius swissprot:DACB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DACB_ECOLI PhylomeDB P24228 http://phylomedb.org/?seqid=P24228 ProteinModelPortal P24228 http://www.proteinmodelportal.org/query/uniprot/P24228 PubMed 16411754 http://www.ncbi.nlm.nih.gov/pubmed/16411754 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2040429 http://www.ncbi.nlm.nih.gov/pubmed/2040429 PubMed 2046551 http://www.ncbi.nlm.nih.gov/pubmed/2046551 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417649 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417649 RefSeq WP_001212619 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001212619 SMR P24228 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P24228 STRING 511145.b3182 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3182&targetmode=cogs STRING COG2027 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2027&targetmode=cogs SUPFAM SSF56601 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56601 TIGRFAMs TIGR00666 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00666 UniProtKB DACB_ECOLI http://www.uniprot.org/uniprot/DACB_ECOLI UniProtKB-AC P24228 http://www.uniprot.org/uniprot/P24228 charge swissprot:DACB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DACB_ECOLI eggNOG COG2027 http://eggnogapi.embl.de/nog_data/html/tree/COG2027 eggNOG ENOG4106HRJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106HRJ epestfind swissprot:DACB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DACB_ECOLI garnier swissprot:DACB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DACB_ECOLI helixturnhelix swissprot:DACB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DACB_ECOLI hmoment swissprot:DACB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DACB_ECOLI iep swissprot:DACB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DACB_ECOLI inforesidue swissprot:DACB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DACB_ECOLI octanol swissprot:DACB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DACB_ECOLI pepcoil swissprot:DACB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DACB_ECOLI pepdigest swissprot:DACB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DACB_ECOLI pepinfo swissprot:DACB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DACB_ECOLI pepnet swissprot:DACB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DACB_ECOLI pepstats swissprot:DACB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DACB_ECOLI pepwheel swissprot:DACB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DACB_ECOLI pepwindow swissprot:DACB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DACB_ECOLI sigcleave swissprot:DACB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DACB_ECOLI ## Database ID URL or Descriptions # AltName Kdo(2)-lipid IV(A) palmitoleoyltransferase {ECO:0000255|HAMAP-Rule MF_01943} # BRENDA 2.3.1.B30 2026 # BioGrid 4260930 142 # CATALYTIC ACTIVITY LPXP_ECOLI A (9Z)-hexadecenoyl-[acyl-carrier protein] + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IV(A) = (Kdo)(2)-((9Z)- hexadecenoyl)-lipid IV(A) + a holo-[acyl-carrier protein]. {ECO 0000255|HAMAP-Rule MF_01943, ECO 0000269|PubMed 10092655}. # CDD cd07984 LPLAT_LABLAT-like # DISRUPTION PHENOTYPE Disruption does not confer any obvious growth phenotype in nutrient broth at low temperatures, but mutant shows a 10-fold increase in sensitivity to rifampicin and vancomycin at 12 degrees Celsius compared with wild type cells. {ECO:0000269|PubMed 11830594}. # EcoGene EG12901 lpxP # FUNCTION LPXP_ECOLI Catalyzes the transfer of palmitoleate from palmitoleoyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(palmitoleoyl)-lipid IV(A). Required for the biosynthesis of a distinct molecular species of lipid A, which is present only in cells grown at low temperatures. It may confer a selective advantage to cells growing at lower temperatures by making the outer membrane a more effective barrier to harmful chemicals. {ECO 0000269|PubMed 10092655, ECO 0000269|PubMed 11830594}. # GO_component GO:0005887 integral component of plasma membrane; IEA:UniProtKB-HAMAP. # GO_function GO:0008951 palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity; IDA:EcoCyc. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0009245 lipid A biosynthetic process; IEA:InterPro. # GO_process GO:0009409 response to cold; IEP:EcoCyc. # GO_process GO:0036104 Kdo2-lipid A biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # HAMAP MF_01942 Lipid_A_LpxL_LpxP # HAMAP MF_01943 Lipid_A_LpxP # INDUCTION LPXP_ECOLI Induced more than 30-fold upon cold shock. The induced activity is maximal after 2 h of cold shock, and then gradually declines but does not disappear (PubMed 10092655). Induced in persister cells (PubMed 16768798). {ECO 0000269|PubMed 10092655, ECO 0000269|PubMed 16768798}. # IntAct P0ACV2 6 # InterPro IPR004960 LipA_acyltrans # InterPro IPR011920 Lipid_A_LpxL_LpxP # InterPro IPR030857 Lipid_A_LpxP # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # MISCELLANEOUS About two-thirds of the lipid A residues of cells grown at 12 degrees Celsius are acylated with palmitoleate rather than laurate. {ECO:0000305|PubMed 11830594}. # Organism LPXP_ECOLI Escherichia coli (strain K12) # PATHWAY LPXP_ECOLI Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. {ECO 0000255|HAMAP-Rule MF_01943, ECO 0000269|PubMed 10092655}. # PATRIC 32120133 VBIEscCol129921_2475 # PIRSF PIRSF026649 MsbB # Pfam PF03279 Lip_A_acyltrans # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LPXP_ECOLI Lipid A biosynthesis palmitoleoyltransferase {ECO 0000255|HAMAP-Rule MF_01943, ECO 0000303|PubMed 11830594} # RefSeq NP_416879 NC_000913.3 # RefSeq WP_000484404 NZ_LN832404.1 # SIMILARITY Belongs to the LpxL/LpxM/LpxP family. LpxP subfamily. {ECO:0000255|HAMAP-Rule MF_01943, ECO:0000305}. # SUBCELLULAR LOCATION LPXP_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01943, ECO 0000305}; Single-pass membrane protein {ECO 0000255|HAMAP-Rule MF_01943}. # TIGRFAMs TIGR02207 lipid_A_htrB # eggNOG COG1560 LUCA # eggNOG ENOG4105D1S Bacteria BLAST swissprot:LPXP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LPXP_ECOLI BioCyc ECOL316407:JW2375-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2375-MONOMER BioCyc EcoCyc:PALMITOTRANS-MONOMER http://biocyc.org/getid?id=EcoCyc:PALMITOTRANS-MONOMER BioCyc MetaCyc:PALMITOTRANS-MONOMER http://biocyc.org/getid?id=MetaCyc:PALMITOTRANS-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.274.14.9677 http://dx.doi.org/10.1074/jbc.274.14.9677 DOI 10.1074/jbc.M200408200 http://dx.doi.org/10.1074/jbc.M200408200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1186/1471-2180-6-53 http://dx.doi.org/10.1186/1471-2180-6-53 EC_number EC:2.3.1.242 {ECO:0000255|HAMAP-Rule:MF_01943, ECO:0000269|PubMed:10092655} http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.242 {ECO:0000255|HAMAP-Rule:MF_01943, ECO:0000269|PubMed:10092655} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U49787 http://www.ebi.ac.uk/ena/data/view/U49787 ENZYME 2.3.1.242 {ECO:0000255|HAMAP-Rule:MF_01943, ECO:0000269|PubMed:10092655} http://enzyme.expasy.org/EC/2.3.1.242 {ECO:0000255|HAMAP-Rule:MF_01943, ECO:0000269|PubMed:10092655} EchoBASE EB2738 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2738 EcoGene EG12901 http://www.ecogene.org/geneInfo.php?eg_id=EG12901 EnsemblBacteria AAC75437 http://www.ensemblgenomes.org/id/AAC75437 EnsemblBacteria AAC75437 http://www.ensemblgenomes.org/id/AAC75437 EnsemblBacteria BAA16248 http://www.ensemblgenomes.org/id/BAA16248 EnsemblBacteria BAA16248 http://www.ensemblgenomes.org/id/BAA16248 EnsemblBacteria BAA16248 http://www.ensemblgenomes.org/id/BAA16248 EnsemblBacteria b2378 http://www.ensemblgenomes.org/id/b2378 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0008951 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008951 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GO_process GO:0009245 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009245 GO_process GO:0009409 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009409 GO_process GO:0036104 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036104 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 946847 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946847 HAMAP MF_01942 http://hamap.expasy.org/unirule/MF_01942 HAMAP MF_01943 http://hamap.expasy.org/unirule/MF_01943 HOGENOM HOG000265960 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000265960&db=HOGENOM6 InParanoid P0ACV2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACV2 IntAct P0ACV2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACV2* IntEnz 2.3.1.242 {ECO:0000255|HAMAP-Rule:MF_01943, ECO:0000269|PubMed:10092655} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.242 {ECO:0000255|HAMAP-Rule:MF_01943, ECO:0000269|PubMed:10092655} InterPro IPR004960 http://www.ebi.ac.uk/interpro/entry/IPR004960 InterPro IPR011920 http://www.ebi.ac.uk/interpro/entry/IPR011920 InterPro IPR030857 http://www.ebi.ac.uk/interpro/entry/IPR030857 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Gene ecj:JW2375 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2375 KEGG_Gene eco:b2378 http://www.genome.jp/dbget-bin/www_bget?eco:b2378 KEGG_Orthology KO:K12974 http://www.genome.jp/dbget-bin/www_bget?KO:K12974 OMA IGIHFMS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IGIHFMS PSORT swissprot:LPXP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LPXP_ECOLI PSORT-B swissprot:LPXP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LPXP_ECOLI PSORT2 swissprot:LPXP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LPXP_ECOLI Pfam PF03279 http://pfam.xfam.org/family/PF03279 Phobius swissprot:LPXP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LPXP_ECOLI PhylomeDB P0ACV2 http://phylomedb.org/?seqid=P0ACV2 ProteinModelPortal P0ACV2 http://www.proteinmodelportal.org/query/uniprot/P0ACV2 PubMed 10092655 http://www.ncbi.nlm.nih.gov/pubmed/10092655 PubMed 11830594 http://www.ncbi.nlm.nih.gov/pubmed/11830594 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16768798 http://www.ncbi.nlm.nih.gov/pubmed/16768798 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416879 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416879 RefSeq WP_000484404 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000484404 SMR P0ACV2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACV2 STRING 511145.b2378 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2378&targetmode=cogs TIGRFAMs TIGR02207 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02207 UniProtKB LPXP_ECOLI http://www.uniprot.org/uniprot/LPXP_ECOLI UniProtKB-AC P0ACV2 http://www.uniprot.org/uniprot/P0ACV2 charge swissprot:LPXP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LPXP_ECOLI eggNOG COG1560 http://eggnogapi.embl.de/nog_data/html/tree/COG1560 eggNOG ENOG4105D1S http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D1S epestfind swissprot:LPXP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LPXP_ECOLI garnier swissprot:LPXP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LPXP_ECOLI helixturnhelix swissprot:LPXP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LPXP_ECOLI hmoment swissprot:LPXP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LPXP_ECOLI iep swissprot:LPXP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LPXP_ECOLI inforesidue swissprot:LPXP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LPXP_ECOLI octanol swissprot:LPXP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LPXP_ECOLI pepcoil swissprot:LPXP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LPXP_ECOLI pepdigest swissprot:LPXP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LPXP_ECOLI pepinfo swissprot:LPXP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LPXP_ECOLI pepnet swissprot:LPXP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LPXP_ECOLI pepstats swissprot:LPXP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LPXP_ECOLI pepwheel swissprot:LPXP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LPXP_ECOLI pepwindow swissprot:LPXP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LPXP_ECOLI sigcleave swissprot:LPXP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LPXP_ECOLI ## Database ID URL or Descriptions # BioGrid 4262342 18 # EcoGene EG13075 cptB # FUNCTION CPTB_ECOLI Antitoxin component of a toxin-antitoxin (TA) module. When coexpressed with cognate toxin CptA, the antitoxin neutralizes CptA's toxicity. Has been suggested to be a transcriptional regulator. {ECO 0000269|PubMed 22239607}. # GO_process GO:0006105 succinate metabolic process; IMP:EcoCyc. # GO_process GO:0017013 protein flavinylation; ISS:EcoCyc. # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.150.250 -; 1. # IntAct P64559 6 # InterPro IPR005631 SDH # Organism CPTB_ECOLI Escherichia coli (strain K12) # PATRIC 32121206 VBIEscCol129921_2991 # PDB 1X6I X-ray; 1.20 A; A/B=1-88 # PDB 1X6J X-ray; 2.00 A; A=1-88 # PIR A65074 A65074 # Pfam PF03937 Sdh5 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CPTB_ECOLI Antitoxin CptB # RefSeq NP_417373 NC_000913.3 # RefSeq WP_000354046 NZ_LN832404.1 # SIMILARITY Belongs to the CptB antitoxin family. {ECO 0000305}. # SUBUNIT Monomer. {ECO:0000269|PubMed 15593094}. # SUPFAM SSF109910 SSF109910 # eggNOG COG2938 LUCA # eggNOG ENOG4105Y75 Bacteria BLAST swissprot:CPTB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CPTB_ECOLI BioCyc ECOL316407:JW2865-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2865-MONOMER BioCyc EcoCyc:G7510-MONOMER http://biocyc.org/getid?id=EcoCyc:G7510-MONOMER COG COG2938 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2938 DOI 10.1002/prot.20337 http://dx.doi.org/10.1002/prot.20337 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1574-6968.2012.02496.x http://dx.doi.org/10.1111/j.1574-6968.2012.02496.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 EchoBASE EB2885 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2885 EcoGene EG13075 http://www.ecogene.org/geneInfo.php?eg_id=EG13075 EnsemblBacteria AAC75935 http://www.ensemblgenomes.org/id/AAC75935 EnsemblBacteria AAC75935 http://www.ensemblgenomes.org/id/AAC75935 EnsemblBacteria BAE76962 http://www.ensemblgenomes.org/id/BAE76962 EnsemblBacteria BAE76962 http://www.ensemblgenomes.org/id/BAE76962 EnsemblBacteria BAE76962 http://www.ensemblgenomes.org/id/BAE76962 EnsemblBacteria b2897 http://www.ensemblgenomes.org/id/b2897 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006105 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006105 GO_process GO:0017013 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017013 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.150.250 http://www.cathdb.info/version/latest/superfamily/1.10.150.250 GeneID 947382 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947382 HOGENOM HOG000160701 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000160701&db=HOGENOM6 InParanoid P64559 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P64559 IntAct P64559 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P64559* InterPro IPR005631 http://www.ebi.ac.uk/interpro/entry/IPR005631 KEGG_Gene ecj:JW2865 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2865 KEGG_Gene eco:b2897 http://www.genome.jp/dbget-bin/www_bget?eco:b2897 KEGG_Orthology KO:K09159 http://www.genome.jp/dbget-bin/www_bget?KO:K09159 OMA DLFAWFM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DLFAWFM PDB 1X6I http://www.ebi.ac.uk/pdbe-srv/view/entry/1X6I PDB 1X6J http://www.ebi.ac.uk/pdbe-srv/view/entry/1X6J PDBsum 1X6I http://www.ebi.ac.uk/pdbsum/1X6I PDBsum 1X6J http://www.ebi.ac.uk/pdbsum/1X6J PSORT swissprot:CPTB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CPTB_ECOLI PSORT-B swissprot:CPTB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CPTB_ECOLI PSORT2 swissprot:CPTB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CPTB_ECOLI Pfam PF03937 http://pfam.xfam.org/family/PF03937 Phobius swissprot:CPTB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CPTB_ECOLI ProteinModelPortal P64559 http://www.proteinmodelportal.org/query/uniprot/P64559 PubMed 15593094 http://www.ncbi.nlm.nih.gov/pubmed/15593094 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22239607 http://www.ncbi.nlm.nih.gov/pubmed/22239607 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417373 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417373 RefSeq WP_000354046 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000354046 SMR P64559 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P64559 STRING 511145.b2897 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2897&targetmode=cogs STRING COG2938 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2938&targetmode=cogs SUPFAM SSF109910 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF109910 UniProtKB CPTB_ECOLI http://www.uniprot.org/uniprot/CPTB_ECOLI UniProtKB-AC P64559 http://www.uniprot.org/uniprot/P64559 charge swissprot:CPTB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CPTB_ECOLI eggNOG COG2938 http://eggnogapi.embl.de/nog_data/html/tree/COG2938 eggNOG ENOG4105Y75 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105Y75 epestfind swissprot:CPTB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CPTB_ECOLI garnier swissprot:CPTB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CPTB_ECOLI helixturnhelix swissprot:CPTB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CPTB_ECOLI hmoment swissprot:CPTB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CPTB_ECOLI iep swissprot:CPTB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CPTB_ECOLI inforesidue swissprot:CPTB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CPTB_ECOLI octanol swissprot:CPTB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CPTB_ECOLI pepcoil swissprot:CPTB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CPTB_ECOLI pepdigest swissprot:CPTB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CPTB_ECOLI pepinfo swissprot:CPTB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CPTB_ECOLI pepnet swissprot:CPTB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CPTB_ECOLI pepstats swissprot:CPTB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CPTB_ECOLI pepwheel swissprot:CPTB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CPTB_ECOLI pepwindow swissprot:CPTB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CPTB_ECOLI sigcleave swissprot:CPTB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CPTB_ECOLI ## Database ID URL or Descriptions # BioGrid 4261532 227 # EcoGene EG13413 csgG # FUNCTION CSGG_ECOLI May be involved in the biogenesis of curli organelles. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IEA:InterPro. # GO_component GO:0031246 intrinsic component of periplasmic side of cell outer membrane; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0022610 biological adhesion; IMP:EcoCyc. # GO_process GO:0044010 single-species biofilm formation; IMP:EcoCyc. # GO_process GO:0071806 protein transmembrane transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0008150 biological_process # GOslim_process GO:0055085 transmembrane transport # InterPro IPR005534 Curli_assmbl/transp-comp_CsgG # KEGG_Brite ko02044 Secretion system # Organism CSGG_ECOLI Escherichia coli (strain K12) # PATRIC 32117307 VBIEscCol129921_1076 # PDB 4UV2 X-ray; 2.80 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P=17-277 # PDB 4UV3 X-ray; 3.59 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R=16-277 # PIR S70783 S70783 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF03783 CsgG # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CSGG_ECOLI Curli production assembly/transport component CsgG # RefSeq NP_415555 NC_000913.3 # RefSeq WP_001189321 NZ_LN832404.1 # SIMILARITY Belongs to the CsgG family. {ECO 0000305}. # SUBCELLULAR LOCATION CSGG_ECOLI Cell membrane {ECO 0000255|PROSITE- ProRule PRU00303}; Lipid-anchor {ECO 0000255|PROSITE- ProRule PRU00303}. # TCDB 1.B.48.1 the curli fiber subunit, csga, porin, csgg (csgg) family # eggNOG COG1462 LUCA # eggNOG ENOG4105P8Q Bacteria BLAST swissprot:CSGG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CSGG_ECOLI BioCyc ECOL316407:JW1020-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1020-MONOMER BioCyc EcoCyc:G6543-MONOMER http://biocyc.org/getid?id=EcoCyc:G6543-MONOMER COG COG1462 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1462 DIP DIP-9331N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9331N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1995.mmi_18040661.x http://dx.doi.org/10.1111/j.1365-2958.1995.mmi_18040661.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AF081826 http://www.ebi.ac.uk/ena/data/view/AF081826 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X90754 http://www.ebi.ac.uk/ena/data/view/X90754 EchoBASE EB3189 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3189 EcoGene EG13413 http://www.ecogene.org/geneInfo.php?eg_id=EG13413 EnsemblBacteria AAC74121 http://www.ensemblgenomes.org/id/AAC74121 EnsemblBacteria AAC74121 http://www.ensemblgenomes.org/id/AAC74121 EnsemblBacteria BAA35818 http://www.ensemblgenomes.org/id/BAA35818 EnsemblBacteria BAA35818 http://www.ensemblgenomes.org/id/BAA35818 EnsemblBacteria BAA35818 http://www.ensemblgenomes.org/id/BAA35818 EnsemblBacteria b1037 http://www.ensemblgenomes.org/id/b1037 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_component GO:0031246 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031246 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0022610 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022610 GO_process GO:0044010 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044010 GO_process GO:0071806 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071806 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 945619 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945619 HOGENOM HOG000295940 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000295940&db=HOGENOM6 InParanoid P0AEA2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEA2 InterPro IPR005534 http://www.ebi.ac.uk/interpro/entry/IPR005534 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW1020 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1020 KEGG_Gene eco:b1037 http://www.genome.jp/dbget-bin/www_bget?eco:b1037 KEGG_Orthology KO:K06214 http://www.genome.jp/dbget-bin/www_bget?KO:K06214 OMA NEPAQLC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NEPAQLC PDB 4UV2 http://www.ebi.ac.uk/pdbe-srv/view/entry/4UV2 PDB 4UV3 http://www.ebi.ac.uk/pdbe-srv/view/entry/4UV3 PDBsum 4UV2 http://www.ebi.ac.uk/pdbsum/4UV2 PDBsum 4UV3 http://www.ebi.ac.uk/pdbsum/4UV3 PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:CSGG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CSGG_ECOLI PSORT-B swissprot:CSGG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CSGG_ECOLI PSORT2 swissprot:CSGG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CSGG_ECOLI Pfam PF03783 http://pfam.xfam.org/family/PF03783 Phobius swissprot:CSGG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CSGG_ECOLI ProteinModelPortal P0AEA2 http://www.proteinmodelportal.org/query/uniprot/P0AEA2 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8817489 http://www.ncbi.nlm.nih.gov/pubmed/8817489 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415555 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415555 RefSeq WP_001189321 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001189321 SMR P0AEA2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEA2 STRING 511145.b1037 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1037&targetmode=cogs STRING COG1462 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1462&targetmode=cogs TCDB 1.B.48.1 http://www.tcdb.org/search/result.php?tc=1.B.48.1 UniProtKB CSGG_ECOLI http://www.uniprot.org/uniprot/CSGG_ECOLI UniProtKB-AC P0AEA2 http://www.uniprot.org/uniprot/P0AEA2 charge swissprot:CSGG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CSGG_ECOLI eggNOG COG1462 http://eggnogapi.embl.de/nog_data/html/tree/COG1462 eggNOG ENOG4105P8Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105P8Q epestfind swissprot:CSGG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CSGG_ECOLI garnier swissprot:CSGG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CSGG_ECOLI helixturnhelix swissprot:CSGG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CSGG_ECOLI hmoment swissprot:CSGG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CSGG_ECOLI iep swissprot:CSGG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CSGG_ECOLI inforesidue swissprot:CSGG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CSGG_ECOLI octanol swissprot:CSGG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CSGG_ECOLI pepcoil swissprot:CSGG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CSGG_ECOLI pepdigest swissprot:CSGG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CSGG_ECOLI pepinfo swissprot:CSGG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CSGG_ECOLI pepnet swissprot:CSGG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CSGG_ECOLI pepstats swissprot:CSGG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CSGG_ECOLI pepwheel swissprot:CSGG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CSGG_ECOLI pepwindow swissprot:CSGG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CSGG_ECOLI sigcleave swissprot:CSGG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CSGG_ECOLI ## Database ID URL or Descriptions # BioGrid 4260454 12 # EcoGene EG12019 yohF # GO_function GO:0016491 oxidoreductase activity; IEA:UniProtKB-KW. # GOslim_function GO:0016491 oxidoreductase activity # Gene3D 3.40.50.720 -; 1. # IntAct P33368 6 # InterPro IPR002347 SDR_fam # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR020904 Sc_DH/Rdtase_CS # KEGG_Brite ko01000 Enzymes # Organism YOHF_ECOLI Escherichia coli (strain K12) # PANTHER PTHR24322 PTHR24322; 2 # PATRIC 32119617 VBIEscCol129921_2219 # PIR H64981 H64981 # PRINTS PR00080 SDRFAMILY # PRINTS PR00081 GDHRDH # PROSITE PS00061 ADH_SHORT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YOHF_ECOLI Uncharacterized oxidoreductase YohF # RefSeq NP_416641 NC_000913.3 # RefSeq WP_000079538 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA60499.1; Type=Frameshift; Positions=185; Note=Produces two separate ORFs.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO 0000305}. # SUPFAM SSF51735 SSF51735 # eggNOG COG1028 LUCA # eggNOG ENOG4105H9W Bacteria BLAST swissprot:YOHF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YOHF_ECOLI BioCyc ECOL316407:JW2125-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2125-MONOMER BioCyc EcoCyc:EG12019-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12019-MONOMER DIP DIP-12806N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12806N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- EchoBASE EB1955 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1955 EcoGene EG12019 http://www.ecogene.org/geneInfo.php?eg_id=EG12019 EnsemblBacteria AAC75198 http://www.ensemblgenomes.org/id/AAC75198 EnsemblBacteria AAC75198 http://www.ensemblgenomes.org/id/AAC75198 EnsemblBacteria BAE76614 http://www.ensemblgenomes.org/id/BAE76614 EnsemblBacteria BAE76614 http://www.ensemblgenomes.org/id/BAE76614 EnsemblBacteria BAE76614 http://www.ensemblgenomes.org/id/BAE76614 EnsemblBacteria b2137 http://www.ensemblgenomes.org/id/b2137 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 949126 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949126 InParanoid P33368 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33368 IntAct P33368 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33368* IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR002347 http://www.ebi.ac.uk/interpro/entry/IPR002347 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR020904 http://www.ebi.ac.uk/interpro/entry/IPR020904 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2125 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2125 KEGG_Gene eco:b2137 http://www.genome.jp/dbget-bin/www_bget?eco:b2137 KEGG_Orthology KO:K00540 http://www.genome.jp/dbget-bin/www_bget?KO:K00540 OMA HSGQPFM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HSGQPFM PANTHER PTHR24322 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24322 PRINTS PR00080 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00080 PRINTS PR00081 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00081 PROSITE PS00061 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00061 PSORT swissprot:YOHF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YOHF_ECOLI PSORT-B swissprot:YOHF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YOHF_ECOLI PSORT2 swissprot:YOHF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YOHF_ECOLI Phobius swissprot:YOHF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YOHF_ECOLI PhylomeDB P33368 http://phylomedb.org/?seqid=P33368 ProteinModelPortal P33368 http://www.proteinmodelportal.org/query/uniprot/P33368 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416641 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416641 RefSeq WP_000079538 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000079538 SMR P33368 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33368 STRING 511145.b2137 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2137&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB YOHF_ECOLI http://www.uniprot.org/uniprot/YOHF_ECOLI UniProtKB-AC P33368 http://www.uniprot.org/uniprot/P33368 charge swissprot:YOHF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YOHF_ECOLI eggNOG COG1028 http://eggnogapi.embl.de/nog_data/html/tree/COG1028 eggNOG ENOG4105H9W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105H9W epestfind swissprot:YOHF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YOHF_ECOLI garnier swissprot:YOHF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YOHF_ECOLI helixturnhelix swissprot:YOHF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YOHF_ECOLI hmoment swissprot:YOHF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YOHF_ECOLI iep swissprot:YOHF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YOHF_ECOLI inforesidue swissprot:YOHF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YOHF_ECOLI octanol swissprot:YOHF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YOHF_ECOLI pepcoil swissprot:YOHF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YOHF_ECOLI pepdigest swissprot:YOHF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YOHF_ECOLI pepinfo swissprot:YOHF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YOHF_ECOLI pepnet swissprot:YOHF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YOHF_ECOLI pepstats swissprot:YOHF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YOHF_ECOLI pepwheel swissprot:YOHF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YOHF_ECOLI pepwindow swissprot:YOHF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YOHF_ECOLI sigcleave swissprot:YOHF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YOHF_ECOLI ## Database ID URL or Descriptions # DISRUPTION PHENOTYPE None seen. An isbE overproducing strain cannot be made in the absence of the sibE gene. {ECO:0000269|PubMed 18710431}. # EcoGene EG14471 ibsE # FUNCTION IBSE_ECOLI May be a toxic protein; overexpression causes cessation of growth. {ECO 0000269|PubMed 18710431}. # GO_process GO:0012501 programmed cell death; IMP:EcoCyc. # GOslim_process GO:0008219 cell death # INDUCTION IBSE_ECOLI The sibE sRNA probably represses expression of ibsE mRNA, either by destabilizing the transcript and/or preventing its translation. A type I toxin antitoxin (TA) system, where expression of the proteinaceous toxin is controlled by an antisense sRNA. # InterPro IPR025881 Toxin_Ibs # MISCELLANEOUS IBSE_ECOLI Part of the SIBe repeat region, encoded on the opposite strand from the sibE RNA. # Organism IBSE_ECOLI Escherichia coli (strain K12) # Pfam PF13956 Ibs_toxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName IBSE_ECOLI Small toxic protein IbsE # RefSeq YP_002791257 NC_000913.3 # SIMILARITY Belongs to the toxic protein ibs family. {ECO 0000305}. BLAST swissprot:IBSE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:IBSE_ECOLI BioCyc EcoCyc:MONOMER0-2855 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2855 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2008.06394.x http://dx.doi.org/10.1111/j.1365-2958.2008.06394.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14471 http://www.ecogene.org/geneInfo.php?eg_id=EG14471 EnsemblBacteria ACO60009 http://www.ensemblgenomes.org/id/ACO60009 EnsemblBacteria ACO60009 http://www.ensemblgenomes.org/id/ACO60009 EnsemblBacteria b4666 http://www.ensemblgenomes.org/id/b4666 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0012501 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0012501 GOslim_process GO:0008219 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008219 GeneID 7751629 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7751629 InterPro IPR025881 http://www.ebi.ac.uk/interpro/entry/IPR025881 KEGG_Gene eco:b4666 http://www.genome.jp/dbget-bin/www_bget?eco:b4666 PSORT swissprot:IBSE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:IBSE_ECOLI PSORT-B swissprot:IBSE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:IBSE_ECOLI PSORT2 swissprot:IBSE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:IBSE_ECOLI Pfam PF13956 http://pfam.xfam.org/family/PF13956 Phobius swissprot:IBSE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:IBSE_ECOLI PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18710431 http://www.ncbi.nlm.nih.gov/pubmed/18710431 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq YP_002791257 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_002791257 STRING 511145.b4666 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4666&targetmode=cogs UniProtKB IBSE_ECOLI http://www.uniprot.org/uniprot/IBSE_ECOLI UniProtKB-AC C1P617 http://www.uniprot.org/uniprot/C1P617 charge swissprot:IBSE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:IBSE_ECOLI epestfind swissprot:IBSE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:IBSE_ECOLI garnier swissprot:IBSE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:IBSE_ECOLI helixturnhelix swissprot:IBSE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:IBSE_ECOLI hmoment swissprot:IBSE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:IBSE_ECOLI iep swissprot:IBSE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:IBSE_ECOLI inforesidue swissprot:IBSE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:IBSE_ECOLI octanol swissprot:IBSE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:IBSE_ECOLI pepcoil swissprot:IBSE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:IBSE_ECOLI pepdigest swissprot:IBSE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:IBSE_ECOLI pepinfo swissprot:IBSE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:IBSE_ECOLI pepnet swissprot:IBSE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:IBSE_ECOLI pepstats swissprot:IBSE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:IBSE_ECOLI pepwheel swissprot:IBSE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:IBSE_ECOLI pepwindow swissprot:IBSE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:IBSE_ECOLI sigcleave swissprot:IBSE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:IBSE_ECOLI ## Database ID URL or Descriptions # BioGrid 4261212 10 # EcoGene EG13547 ivy # FUNCTION IVY_ECOLI Strong inhibitor of lysozyme C. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0060241 lysozyme inhibitor activity; IDA:EcoCyc. # GO_process GO:0050790 regulation of catalytic activity; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0030234 enzyme regulator activity # GOslim_process GO:0008150 biological_process # Gene3D 3.40.1420.10 -; 1. # InterPro IPR014453 Ihibitor_vertebrate_lysozyme # Organism IVY_ECOLI Escherichia coli (strain K12) # PATRIC 32115555 VBIEscCol129921_0222 # PDB 1GPQ X-ray; 1.60 A; A/B=29-156 # PDB 1XS0 X-ray; 1.58 A; A/B/C=29-156 # PIR E64746 E64746 # PIRSF PIRSF009103 Ivy # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName IVY_ECOLI Inhibitor of vertebrate lysozyme # RefSeq NP_414755 NC_000913.3 # SIMILARITY Belongs to the ivy family. {ECO 0000305}. # SUBCELLULAR LOCATION IVY_ECOLI Periplasm. # SUBUNIT IVY_ECOLI Homodimer. # SUPFAM SSF89872 SSF89872 # eggNOG ENOG4108WN0 Bacteria # eggNOG ENOG4111K9M LUCA BLAST swissprot:IVY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:IVY_ECOLI BioCyc ECOL316407:JW0210-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0210-MONOMER BioCyc EcoCyc:G6104-MONOMER http://biocyc.org/getid?id=EcoCyc:G6104-MONOMER DIP DIP-10051N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10051N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M010297200 http://dx.doi.org/10.1074/jbc.M010297200 DOI 10.1107/S0907444900015316 http://dx.doi.org/10.1107/S0907444900015316 DOI 10.1111/j.1574-6968.1998.tb13343.x http://dx.doi.org/10.1111/j.1574-6968.1998.tb13343.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EchoBASE EB3317 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3317 EcoGene EG13547 http://www.ecogene.org/geneInfo.php?eg_id=EG13547 EnsemblBacteria AAC73324 http://www.ensemblgenomes.org/id/AAC73324 EnsemblBacteria AAC73324 http://www.ensemblgenomes.org/id/AAC73324 EnsemblBacteria BAA77890 http://www.ensemblgenomes.org/id/BAA77890 EnsemblBacteria BAA77890 http://www.ensemblgenomes.org/id/BAA77890 EnsemblBacteria BAA77890 http://www.ensemblgenomes.org/id/BAA77890 EnsemblBacteria b0220 http://www.ensemblgenomes.org/id/b0220 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0060241 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060241 GO_process GO:0050790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050790 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.1420.10 http://www.cathdb.info/version/latest/superfamily/3.40.1420.10 GeneID 946530 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946530 HOGENOM HOG000117011 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117011&db=HOGENOM6 InParanoid P0AD59 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AD59 InterPro IPR014453 http://www.ebi.ac.uk/interpro/entry/IPR014453 KEGG_Gene ecj:JW0210 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0210 KEGG_Gene eco:b0220 http://www.genome.jp/dbget-bin/www_bget?eco:b0220 OMA DCAAQNI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DCAAQNI PDB 1GPQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1GPQ PDB 1XS0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1XS0 PDBsum 1GPQ http://www.ebi.ac.uk/pdbsum/1GPQ PDBsum 1XS0 http://www.ebi.ac.uk/pdbsum/1XS0 PSORT swissprot:IVY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:IVY_ECOLI PSORT-B swissprot:IVY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:IVY_ECOLI PSORT2 swissprot:IVY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:IVY_ECOLI Phobius swissprot:IVY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:IVY_ECOLI ProteinModelPortal P0AD59 http://www.proteinmodelportal.org/query/uniprot/P0AD59 PubMed 11092949 http://www.ncbi.nlm.nih.gov/pubmed/11092949 PubMed 11278658 http://www.ncbi.nlm.nih.gov/pubmed/11278658 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9868784 http://www.ncbi.nlm.nih.gov/pubmed/9868784 RefSeq NP_414755 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414755 SMR P0AD59 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AD59 STRING 511145.b0220 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0220&targetmode=cogs SUPFAM SSF89872 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF89872 SWISS-2DPAGE P0AD59 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AD59 UniProtKB IVY_ECOLI http://www.uniprot.org/uniprot/IVY_ECOLI UniProtKB-AC P0AD59 http://www.uniprot.org/uniprot/P0AD59 charge swissprot:IVY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:IVY_ECOLI eggNOG ENOG4108WN0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108WN0 eggNOG ENOG4111K9M http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111K9M epestfind swissprot:IVY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:IVY_ECOLI garnier swissprot:IVY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:IVY_ECOLI helixturnhelix swissprot:IVY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:IVY_ECOLI hmoment swissprot:IVY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:IVY_ECOLI iep swissprot:IVY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:IVY_ECOLI inforesidue swissprot:IVY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:IVY_ECOLI octanol swissprot:IVY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:IVY_ECOLI pepcoil swissprot:IVY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:IVY_ECOLI pepdigest swissprot:IVY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:IVY_ECOLI pepinfo swissprot:IVY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:IVY_ECOLI pepnet swissprot:IVY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:IVY_ECOLI pepstats swissprot:IVY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:IVY_ECOLI pepwheel swissprot:IVY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:IVY_ECOLI pepwindow swissprot:IVY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:IVY_ECOLI sigcleave swissprot:IVY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:IVY_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES MAO2_ECOLI Kinetic parameters KM=3.41 mM for L-malate {ECO 0000269|PubMed 17557829}; KM=0.0415 mM for NADP {ECO 0000269|PubMed 17557829}; KM=6.21 mM for pyruvate {ECO 0000269|PubMed 17557829}; pH dependence Optimum pH is 7.5 for L-malate. {ECO 0000269|PubMed 17557829}; # BRENDA 1.1.1.40 2026 # BioGrid 4260925 8 # CATALYTIC ACTIVITY MAO2_ECOLI (S)-malate + NADP(+) = pyruvate + CO(2) + NADPH. # CATALYTIC ACTIVITY MAO2_ECOLI Oxaloacetate = pyruvate + CO(2). # COFACTOR MAO2_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 17557829}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 17557829}; Note=Divalent metal cations. Prefers magnesium or manganese. {ECO 0000269|PubMed 17557829}; # DOMAIN MAO2_ECOLI The-C-terminal phosphate acetyltransferase domain is responsible for oligomerization, and is responsible for inhibition by acetyl-CoA and activation by glutamate, aspartate, and glucose- 6-phosphate as shown by its deletion. The isolated domain does not catalyze the interconversion of acetyl-CoA and acetyl-phosphate. {ECO 0000269|PubMed 17557829}. # ENZYME REGULATION Inhibited by 4 mM Mg(2+) and acetyl-CoA, competitively inhibited by fumarate and oxaloacetate. Activated by glutamate and aspartate, glucose-6-phosphate, acetyl-phosphate and 2 mM KCl. {ECO:0000269|PubMed 17557829}. # EcoGene EG14193 maeB # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity; IEA:InterPro. # GO_function GO:0004473 malate dehydrogenase (decarboxylating) (NADP+) activity; IDA:EcoCyc. # GO_function GO:0008948 oxaloacetate decarboxylase activity; IEA:UniProtKB-EC. # GO_function GO:0016746 transferase activity, transferring acyl groups; IEA:InterPro. # GO_function GO:0030145 manganese ion binding; IDA:EcoCyc. # GO_function GO:0051287 NAD binding; IEA:InterPro. # GO_process GO:0006108 malate metabolic process; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.10380 -; 1. # Gene3D 3.40.50.720 -; 1. # IntAct P76558 9 # InterPro IPR002505 PTA_PTB # InterPro IPR012188 ME_PTA # InterPro IPR012301 Malic_N_dom # InterPro IPR012302 Malic_NAD-bd # InterPro IPR015884 Malic_enzyme_CS # InterPro IPR016040 NAD(P)-bd_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00620 Pyruvate metabolism # KEGG_Pathway ko00710 Carbon fixation in photosynthetic organisms # MISCELLANEOUS MAO2_ECOLI Cannot use NAD(+). # Organism MAO2_ECOLI Escherichia coli (strain K12) # PATRIC 32120309 VBIEscCol129921_2557 # PIR F65021 F65021 # PIRSF PIRSF036684 ME_PTA # PROSITE PS00331 MALIC_ENZYMES # Pfam PF00390 malic # Pfam PF01515 PTA_PTB # Pfam PF03949 Malic_M # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MAO2_ECOLI NADP-dependent malic enzyme # RefSeq NP_416958 NC_000913.3 # RefSeq WP_000342644 NZ_LN832404.1 # SIMILARITY In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family. {ECO 0000305}. # SIMILARITY In the N-terminal section; belongs to the malic enzymes family. {ECO 0000305}. # SMART SM00919 Malic_M # SMART SM01274 malic # SUBUNIT MAO2_ECOLI Homooligomer, possibly an octamer. # SUPFAM SSF51735 SSF51735 # eggNOG COG0280 LUCA # eggNOG COG0281 LUCA # eggNOG ENOG4105C6K Bacteria BLAST swissprot:MAO2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MAO2_ECOLI BioCyc ECOL316407:JW2447-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2447-MONOMER BioCyc EcoCyc:MALIC-NADP-MONOMER http://biocyc.org/getid?id=EcoCyc:MALIC-NADP-MONOMER BioCyc MetaCyc:MALIC-NADP-MONOMER http://biocyc.org/getid?id=MetaCyc:MALIC-NADP-MONOMER COG COG0280 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0280 COG COG0281 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0281 DIP DIP-10141N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10141N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00428-07 http://dx.doi.org/10.1128/JB.00428-07 EC_number EC:1.1.1.40 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.40 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.1.1.40 http://enzyme.expasy.org/EC/1.1.1.40 EchoBASE EB3945 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3945 EcoGene EG14193 http://www.ecogene.org/geneInfo.php?eg_id=EG14193 EnsemblBacteria AAC75516 http://www.ensemblgenomes.org/id/AAC75516 EnsemblBacteria AAC75516 http://www.ensemblgenomes.org/id/AAC75516 EnsemblBacteria BAA16337 http://www.ensemblgenomes.org/id/BAA16337 EnsemblBacteria BAA16337 http://www.ensemblgenomes.org/id/BAA16337 EnsemblBacteria BAA16337 http://www.ensemblgenomes.org/id/BAA16337 EnsemblBacteria b2463 http://www.ensemblgenomes.org/id/b2463 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004471 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004471 GO_function GO:0004473 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004473 GO_function GO:0008948 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008948 GO_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_function GO:0051287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051287 GO_process GO:0006108 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006108 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.10380 http://www.cathdb.info/version/latest/superfamily/3.40.50.10380 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 946947 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946947 HOGENOM HOG000132448 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000132448&db=HOGENOM6 InParanoid P76558 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76558 IntAct P76558 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76558* IntEnz 1.1.1.40 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.40 InterPro IPR002505 http://www.ebi.ac.uk/interpro/entry/IPR002505 InterPro IPR012188 http://www.ebi.ac.uk/interpro/entry/IPR012188 InterPro IPR012301 http://www.ebi.ac.uk/interpro/entry/IPR012301 InterPro IPR012302 http://www.ebi.ac.uk/interpro/entry/IPR012302 InterPro IPR015884 http://www.ebi.ac.uk/interpro/entry/IPR015884 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2447 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2447 KEGG_Gene eco:b2463 http://www.genome.jp/dbget-bin/www_bget?eco:b2463 KEGG_Orthology KO:K00029 http://www.genome.jp/dbget-bin/www_bget?KO:K00029 KEGG_Pathway ko00620 http://www.genome.jp/kegg-bin/show_pathway?ko00620 KEGG_Pathway ko00710 http://www.genome.jp/kegg-bin/show_pathway?ko00710 KEGG_Reaction rn:R00216 http://www.genome.jp/dbget-bin/www_bget?rn:R00216 OMA DIMPDSP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DIMPDSP PROSITE PS00331 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00331 PSORT swissprot:MAO2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MAO2_ECOLI PSORT-B swissprot:MAO2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MAO2_ECOLI PSORT2 swissprot:MAO2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MAO2_ECOLI Pfam PF00390 http://pfam.xfam.org/family/PF00390 Pfam PF01515 http://pfam.xfam.org/family/PF01515 Pfam PF03949 http://pfam.xfam.org/family/PF03949 Phobius swissprot:MAO2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MAO2_ECOLI PhylomeDB P76558 http://phylomedb.org/?seqid=P76558 ProteinModelPortal P76558 http://www.proteinmodelportal.org/query/uniprot/P76558 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17557829 http://www.ncbi.nlm.nih.gov/pubmed/17557829 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 36376 http://www.ncbi.nlm.nih.gov/pubmed/36376 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416958 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416958 RefSeq WP_000342644 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000342644 SMART SM00919 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00919 SMART SM01274 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01274 SMR P76558 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76558 STRING 511145.b2463 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2463&targetmode=cogs STRING COG0280 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0280&targetmode=cogs STRING COG0281 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0281&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB MAO2_ECOLI http://www.uniprot.org/uniprot/MAO2_ECOLI UniProtKB-AC P76558 http://www.uniprot.org/uniprot/P76558 charge swissprot:MAO2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MAO2_ECOLI eggNOG COG0280 http://eggnogapi.embl.de/nog_data/html/tree/COG0280 eggNOG COG0281 http://eggnogapi.embl.de/nog_data/html/tree/COG0281 eggNOG ENOG4105C6K http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C6K epestfind swissprot:MAO2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MAO2_ECOLI garnier swissprot:MAO2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MAO2_ECOLI helixturnhelix swissprot:MAO2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MAO2_ECOLI hmoment swissprot:MAO2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MAO2_ECOLI iep swissprot:MAO2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MAO2_ECOLI inforesidue swissprot:MAO2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MAO2_ECOLI octanol swissprot:MAO2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MAO2_ECOLI pepcoil swissprot:MAO2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MAO2_ECOLI pepdigest swissprot:MAO2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MAO2_ECOLI pepinfo swissprot:MAO2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MAO2_ECOLI pepnet swissprot:MAO2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MAO2_ECOLI pepstats swissprot:MAO2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MAO2_ECOLI pepwheel swissprot:MAO2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MAO2_ECOLI pepwindow swissprot:MAO2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MAO2_ECOLI sigcleave swissprot:MAO2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MAO2_ECOLI ## Database ID URL or Descriptions # BioGrid 4263529 9 # DISRUPTION PHENOTYPE Cells enhance strongly the transcription of puuE. {ECO:0000269|PubMed 20639325}. # EcoGene EG12431 puuR # FUNCTION PUUR_ECOLI Represses puuA, puuD and puuP. {ECO 0000269|PubMed 15590624, ECO 0000269|PubMed 20639325}. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0043565 sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IMP:UniProtKB. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0009447 putrescine catabolic process; IEA:UniProtKB-UniPathway. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.260.40 -; 1. # Gene3D 2.60.120.10 -; 1. # InterPro IPR001387 Cro/C1-type_HTH # InterPro IPR010982 Lambda_DNA-bd_dom # InterPro IPR011051 RmlC_Cupin # InterPro IPR013096 Cupin_2 # InterPro IPR014710 RmlC-like_jellyroll # KEGG_Brite ko03000 Transcription factors # Organism PUUR_ECOLI Escherichia coli (strain K12) # PATHWAY PUUR_ECOLI Amine and polyamine degradation; putrescine degradation [regulation]. # PATRIC 32117870 VBIEscCol129921_1355 # PIR F64878 F64878 # PROSITE PS50943 HTH_CROC1 # Pfam PF01381 HTH_3 # Pfam PF07883 Cupin_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PUUR_ECOLI HTH-type transcriptional regulator PuuR # RefSeq NP_415815 NC_000913.3 # RefSeq WP_001278727 NZ_LN832404.1 # SIMILARITY Contains 1 HTH cro/C1-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00257}. # SMART SM00530 HTH_XRE # SUPFAM SSF47413 SSF47413 # SUPFAM SSF51182 SSF51182 # eggNOG ENOG4107VRI Bacteria # eggNOG ENOG4111ISD LUCA BLAST swissprot:PUUR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PUUR_ECOLI BioCyc ECOL316407:JW1292-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1292-MONOMER BioCyc EcoCyc:EG12431-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12431-MONOMER COG COG1396 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1396 DIP DIP-48257N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48257N DOI 10.1016/0378-1119(91)90028-A http://dx.doi.org/10.1016/0378-1119(91)90028-A DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M411114200 http://dx.doi.org/10.1074/jbc.M411114200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00308-10 http://dx.doi.org/10.1128/JB.00308-10 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M38433 http://www.ebi.ac.uk/ena/data/view/M38433 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2327 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2327 EcoGene EG12431 http://www.ecogene.org/geneInfo.php?eg_id=EG12431 EnsemblBacteria AAC74381 http://www.ensemblgenomes.org/id/AAC74381 EnsemblBacteria AAC74381 http://www.ensemblgenomes.org/id/AAC74381 EnsemblBacteria BAA14868 http://www.ensemblgenomes.org/id/BAA14868 EnsemblBacteria BAA14868 http://www.ensemblgenomes.org/id/BAA14868 EnsemblBacteria BAA14868 http://www.ensemblgenomes.org/id/BAA14868 EnsemblBacteria b1299 http://www.ensemblgenomes.org/id/b1299 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0009447 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009447 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.260.40 http://www.cathdb.info/version/latest/superfamily/1.10.260.40 Gene3D 2.60.120.10 http://www.cathdb.info/version/latest/superfamily/2.60.120.10 GeneID 945886 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945886 HOGENOM HOG000263463 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000263463&db=HOGENOM6 InParanoid P0A9U6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9U6 IntAct P0A9U6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9U6* InterPro IPR001387 http://www.ebi.ac.uk/interpro/entry/IPR001387 InterPro IPR010982 http://www.ebi.ac.uk/interpro/entry/IPR010982 InterPro IPR011051 http://www.ebi.ac.uk/interpro/entry/IPR011051 InterPro IPR013096 http://www.ebi.ac.uk/interpro/entry/IPR013096 InterPro IPR014710 http://www.ebi.ac.uk/interpro/entry/IPR014710 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW1292 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1292 KEGG_Gene eco:b1299 http://www.genome.jp/dbget-bin/www_bget?eco:b1299 KEGG_Orthology KO:K14056 http://www.genome.jp/dbget-bin/www_bget?KO:K14056 MINT MINT-1257910 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1257910 OMA SMKLIHN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SMKLIHN PROSITE PS50943 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50943 PSORT swissprot:PUUR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PUUR_ECOLI PSORT-B swissprot:PUUR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PUUR_ECOLI PSORT2 swissprot:PUUR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PUUR_ECOLI Pfam PF01381 http://pfam.xfam.org/family/PF01381 Pfam PF07883 http://pfam.xfam.org/family/PF07883 Phobius swissprot:PUUR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PUUR_ECOLI PhylomeDB P0A9U6 http://phylomedb.org/?seqid=P0A9U6 ProteinModelPortal P0A9U6 http://www.proteinmodelportal.org/query/uniprot/P0A9U6 PubMed 15590624 http://www.ncbi.nlm.nih.gov/pubmed/15590624 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1840553 http://www.ncbi.nlm.nih.gov/pubmed/1840553 PubMed 20639325 http://www.ncbi.nlm.nih.gov/pubmed/20639325 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415815 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415815 RefSeq WP_001278727 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001278727 SMART SM00530 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00530 SMR P0A9U6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9U6 STRING 511145.b1299 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1299&targetmode=cogs STRING COG1396 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1396&targetmode=cogs SUPFAM SSF47413 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47413 SUPFAM SSF51182 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51182 UniProtKB PUUR_ECOLI http://www.uniprot.org/uniprot/PUUR_ECOLI UniProtKB-AC P0A9U6 http://www.uniprot.org/uniprot/P0A9U6 charge swissprot:PUUR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PUUR_ECOLI eggNOG ENOG4107VRI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107VRI eggNOG ENOG4111ISD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111ISD epestfind swissprot:PUUR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PUUR_ECOLI garnier swissprot:PUUR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PUUR_ECOLI helixturnhelix swissprot:PUUR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PUUR_ECOLI hmoment swissprot:PUUR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PUUR_ECOLI iep swissprot:PUUR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PUUR_ECOLI inforesidue swissprot:PUUR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PUUR_ECOLI octanol swissprot:PUUR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PUUR_ECOLI pepcoil swissprot:PUUR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PUUR_ECOLI pepdigest swissprot:PUUR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PUUR_ECOLI pepinfo swissprot:PUUR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PUUR_ECOLI pepnet swissprot:PUUR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PUUR_ECOLI pepstats swissprot:PUUR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PUUR_ECOLI pepwheel swissprot:PUUR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PUUR_ECOLI pepwindow swissprot:PUUR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PUUR_ECOLI sigcleave swissprot:PUUR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PUUR_ECOLI ## Database ID URL or Descriptions # AltName COAE_ECOLI Dephosphocoenzyme A kinase # BIOPHYSICOCHEMICAL PROPERTIES pH dependence Optimum pH is 8.5.; # BRENDA 2.7.1.24 2026 # BioGrid 4261116 230 # CATALYTIC ACTIVITY COAE_ECOLI ATP + 3'-dephospho-CoA = ADP + CoA. # CDD cd02022 DPCK # EcoGene EG12312 coaE # FUNCTION COAE_ECOLI Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0004140 dephospho-CoA kinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_process GO:0015937 coenzyme A biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.300 -; 1. # HAMAP MF_00376 Dephospho_CoA_kinase # InterPro IPR001977 Depp_CoAkinase # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00770 Pantothenate and CoA biosynthesis # Organism COAE_ECOLI Escherichia coli (strain K12) # PATHWAY Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate step 5/5. # PATRIC 32115309 VBIEscCol129921_0106 # PDB 1N3B X-ray; 1.80 A; A/B/C=1-206 # PDB 1T3H X-ray; 2.50 A; A/B/C=1-206 # PDB 1VHL X-ray; 1.65 A; A/B/C=2-206 # PDB 1VHT X-ray; 1.59 A; A/B/C=2-206 # PDB 1VIY X-ray; 1.89 A; A/B/C=2-206 # PIR G64732 G64732 # PROSITE PS51219 DPCK # Pfam PF01121 CoaE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName COAE_ECOLI Dephospho-CoA kinase # RefSeq NP_414645 NC_000913.3 # RefSeq WP_001269520 NZ_LN832404.1 # SIMILARITY Belongs to the CoaE family. {ECO 0000305}. # SIMILARITY Contains 1 DPCK (dephospho-CoA kinase) domain. {ECO 0000305}. # SUBCELLULAR LOCATION COAE_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Monomer. {ECO 0000305}. # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR00152 TIGR00152 # UniPathway UPA00241 UER00356 # eggNOG COG0237 LUCA # eggNOG ENOG4108ZQD Bacteria BLAST swissprot:COAE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:COAE_ECOLI BioCyc ECOL316407:JW0100-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0100-MONOMER BioCyc EcoCyc:EG12312-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12312-MONOMER BioCyc MetaCyc:EG12312-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12312-MONOMER COG COG0237 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0237 DIP DIP-47935N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47935N DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.183.9.2774-2778.2001 http://dx.doi.org/10.1128/JB.183.9.2774-2778.2001 EC_number EC:2.7.1.24 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.24 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.24 http://enzyme.expasy.org/EC/2.7.1.24 EchoBASE EB2218 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2218 EcoGene EG12312 http://www.ecogene.org/geneInfo.php?eg_id=EG12312 EnsemblBacteria AAC73214 http://www.ensemblgenomes.org/id/AAC73214 EnsemblBacteria AAC73214 http://www.ensemblgenomes.org/id/AAC73214 EnsemblBacteria BAE76040 http://www.ensemblgenomes.org/id/BAE76040 EnsemblBacteria BAE76040 http://www.ensemblgenomes.org/id/BAE76040 EnsemblBacteria BAE76040 http://www.ensemblgenomes.org/id/BAE76040 EnsemblBacteria b0103 http://www.ensemblgenomes.org/id/b0103 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004140 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004140 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0015937 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015937 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 949060 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949060 HAMAP MF_00376 http://hamap.expasy.org/unirule/MF_00376 HOGENOM HOG000020769 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000020769&db=HOGENOM6 InParanoid P0A6I9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6I9 IntAct P0A6I9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6I9* IntEnz 2.7.1.24 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.24 InterPro IPR001977 http://www.ebi.ac.uk/interpro/entry/IPR001977 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0100 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0100 KEGG_Gene eco:b0103 http://www.genome.jp/dbget-bin/www_bget?eco:b0103 KEGG_Orthology KO:K00859 http://www.genome.jp/dbget-bin/www_bget?KO:K00859 KEGG_Pathway ko00770 http://www.genome.jp/kegg-bin/show_pathway?ko00770 KEGG_Reaction rn:R00130 http://www.genome.jp/dbget-bin/www_bget?rn:R00130 OMA KKRYPVS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KKRYPVS PDB 1N3B http://www.ebi.ac.uk/pdbe-srv/view/entry/1N3B PDB 1T3H http://www.ebi.ac.uk/pdbe-srv/view/entry/1T3H PDB 1VHL http://www.ebi.ac.uk/pdbe-srv/view/entry/1VHL PDB 1VHT http://www.ebi.ac.uk/pdbe-srv/view/entry/1VHT PDB 1VIY http://www.ebi.ac.uk/pdbe-srv/view/entry/1VIY PDBsum 1N3B http://www.ebi.ac.uk/pdbsum/1N3B PDBsum 1T3H http://www.ebi.ac.uk/pdbsum/1T3H PDBsum 1VHL http://www.ebi.ac.uk/pdbsum/1VHL PDBsum 1VHT http://www.ebi.ac.uk/pdbsum/1VHT PDBsum 1VIY http://www.ebi.ac.uk/pdbsum/1VIY PROSITE PS51219 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51219 PSORT swissprot:COAE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:COAE_ECOLI PSORT-B swissprot:COAE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:COAE_ECOLI PSORT2 swissprot:COAE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:COAE_ECOLI Pfam PF01121 http://pfam.xfam.org/family/PF01121 Phobius swissprot:COAE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:COAE_ECOLI PhylomeDB P0A6I9 http://phylomedb.org/?seqid=P0A6I9 ProteinModelPortal P0A6I9 http://www.proteinmodelportal.org/query/uniprot/P0A6I9 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 11292795 http://www.ncbi.nlm.nih.gov/pubmed/11292795 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414645 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414645 RefSeq WP_001269520 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001269520 SMR P0A6I9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6I9 STRING 511145.b0103 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0103&targetmode=cogs STRING COG0237 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0237&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR00152 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00152 UniProtKB COAE_ECOLI http://www.uniprot.org/uniprot/COAE_ECOLI UniProtKB-AC P0A6I9 http://www.uniprot.org/uniprot/P0A6I9 charge swissprot:COAE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:COAE_ECOLI eggNOG COG0237 http://eggnogapi.embl.de/nog_data/html/tree/COG0237 eggNOG ENOG4108ZQD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZQD epestfind swissprot:COAE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:COAE_ECOLI garnier swissprot:COAE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:COAE_ECOLI helixturnhelix swissprot:COAE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:COAE_ECOLI hmoment swissprot:COAE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:COAE_ECOLI iep swissprot:COAE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:COAE_ECOLI inforesidue swissprot:COAE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:COAE_ECOLI octanol swissprot:COAE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:COAE_ECOLI pepcoil swissprot:COAE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:COAE_ECOLI pepdigest swissprot:COAE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:COAE_ECOLI pepinfo swissprot:COAE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:COAE_ECOLI pepnet swissprot:COAE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:COAE_ECOLI pepstats swissprot:COAE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:COAE_ECOLI pepwheel swissprot:COAE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:COAE_ECOLI pepwindow swissprot:COAE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:COAE_ECOLI sigcleave swissprot:COAE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:COAE_ECOLI ## Database ID URL or Descriptions # BioGrid 4263225 9 # EcoGene EG11342 ychE # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR002771 Multi_antbiot-R_MarC # Organism YCHE_ECOLI Escherichia coli (strain K12) # PATRIC 32117742 VBIEscCol129921_1291 # PIR E64871 E64871 # Pfam PF01914 MarC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCHE_ECOLI UPF0056 membrane protein YhcE # RefSeq NP_415758 NC_000913.3 # RefSeq WP_000616554 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0056 (MarC) family. {ECO 0000305}. # SUBCELLULAR LOCATION YCHE_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # TCDB 2.A.95.1 the 6tms neutral amino acid transporter (naat) family # TIGRFAMs TIGR00427 TIGR00427 # eggNOG COG2095 LUCA # eggNOG ENOG4105EZI Bacteria BLAST swissprot:YCHE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCHE_ECOLI BioCyc ECOL316407:JW1229-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1229-MONOMER BioCyc EcoCyc:EG11342-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11342-MONOMER DOI 10.1016/0014-5793(91)80358-A http://dx.doi.org/10.1016/0014-5793(91)80358-A DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X59501 http://www.ebi.ac.uk/ena/data/view/X59501 EchoBASE EB1318 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1318 EcoGene EG11342 http://www.ecogene.org/geneInfo.php?eg_id=EG11342 EnsemblBacteria AAC74324 http://www.ensemblgenomes.org/id/AAC74324 EnsemblBacteria AAC74324 http://www.ensemblgenomes.org/id/AAC74324 EnsemblBacteria BAA36122 http://www.ensemblgenomes.org/id/BAA36122 EnsemblBacteria BAA36122 http://www.ensemblgenomes.org/id/BAA36122 EnsemblBacteria BAA36122 http://www.ensemblgenomes.org/id/BAA36122 EnsemblBacteria b1242 http://www.ensemblgenomes.org/id/b1242 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 945836 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945836 HOGENOM HOG000112971 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000112971&db=HOGENOM6 InParanoid P25743 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P25743 InterPro IPR002771 http://www.ebi.ac.uk/interpro/entry/IPR002771 KEGG_Gene ecj:JW1229 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1229 KEGG_Gene eco:b1242 http://www.genome.jp/dbget-bin/www_bget?eco:b1242 OMA AIILWTS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AIILWTS PSORT swissprot:YCHE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCHE_ECOLI PSORT-B swissprot:YCHE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCHE_ECOLI PSORT2 swissprot:YCHE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCHE_ECOLI Pfam PF01914 http://pfam.xfam.org/family/PF01914 Phobius swissprot:YCHE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCHE_ECOLI PhylomeDB P25743 http://phylomedb.org/?seqid=P25743 ProteinModelPortal P25743 http://www.proteinmodelportal.org/query/uniprot/P25743 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2015910 http://www.ncbi.nlm.nih.gov/pubmed/2015910 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415758 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415758 RefSeq WP_000616554 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000616554 STRING 511145.b1242 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1242&targetmode=cogs TCDB 2.A.95.1 http://www.tcdb.org/search/result.php?tc=2.A.95.1 TIGRFAMs TIGR00427 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00427 UniProtKB YCHE_ECOLI http://www.uniprot.org/uniprot/YCHE_ECOLI UniProtKB-AC P25743 http://www.uniprot.org/uniprot/P25743 charge swissprot:YCHE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCHE_ECOLI eggNOG COG2095 http://eggnogapi.embl.de/nog_data/html/tree/COG2095 eggNOG ENOG4105EZI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EZI epestfind swissprot:YCHE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCHE_ECOLI garnier swissprot:YCHE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCHE_ECOLI helixturnhelix swissprot:YCHE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCHE_ECOLI hmoment swissprot:YCHE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCHE_ECOLI iep swissprot:YCHE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCHE_ECOLI inforesidue swissprot:YCHE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCHE_ECOLI octanol swissprot:YCHE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCHE_ECOLI pepcoil swissprot:YCHE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCHE_ECOLI pepdigest swissprot:YCHE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCHE_ECOLI pepinfo swissprot:YCHE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCHE_ECOLI pepnet swissprot:YCHE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCHE_ECOLI pepstats swissprot:YCHE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCHE_ECOLI pepwheel swissprot:YCHE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCHE_ECOLI pepwindow swissprot:YCHE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCHE_ECOLI sigcleave swissprot:YCHE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCHE_ECOLI ## Database ID URL or Descriptions # AltName PSPF_ECOLI Phage shock protein F # BioGrid 4263525 650 # ENZYME REGULATION ATPase activity is inhibited by interaction with PspA. Under inducing conditions, the interaction is disrupted, allowing activation of psp transcription. {ECO:0000269|PubMed 19804784}. # EcoGene EG12344 pspF # FUNCTION PSPF_ECOLI Transcriptional activator for the phage shock protein (psp) operon (pspABCDE) and pspG gene. {ECO 0000269|PubMed 15485810, ECO 0000269|PubMed 19804784, ECO 0000269|PubMed 8606168}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0043565 sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0000160 phosphorelay signal transduction system; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.60 -; 1. # Gene3D 3.40.50.300 -; 1. # IntAct P37344 3 # InterPro IPR002078 Sigma_54_int # InterPro IPR002197 HTH_Fis # InterPro IPR003593 AAA+_ATPase # InterPro IPR009057 Homeodomain-like # InterPro IPR014317 Transcription_activator_PspF # InterPro IPR025943 Sigma_54_int_dom_ATP-bd_2 # InterPro IPR025944 Sigma_54_int_dom_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko03000 Transcription factors # Organism PSPF_ECOLI Escherichia coli (strain K12) # PATRIC 32117878 VBIEscCol129921_1359 # PDB 2BJV X-ray; 1.70 A; A=1-265 # PDB 2BJW X-ray; 1.75 A; A=1-265 # PDB 2C96 X-ray; 1.80 A; A=1-265 # PDB 2C98 X-ray; 1.90 A; A=1-265 # PDB 2C99 X-ray; 1.90 A; A=1-265 # PDB 2C9C X-ray; 2.10 A; A=1-265 # PDB 2VII X-ray; 2.85 A; A=1-259 # PDB 4QNM X-ray; 1.63 A; A=1-265 # PDB 4QNR X-ray; 1.54 A; A=1-265 # PDB 4QOS X-ray; 1.42 A; A=1-265 # PIR B64879 B64879 # PRINTS PR01590 HTHFIS # PROSITE PS00676 SIGMA54_INTERACT_2 # PROSITE PS00688 SIGMA54_INTERACT_3 # PROSITE PS50045 SIGMA54_INTERACT_4 # Pfam PF00158 Sigma54_activat # Pfam PF02954 HTH_8 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PSPF_ECOLI Psp operon transcriptional activator # RefSeq NP_415819 NC_000913.3 # RefSeq WP_001301108 NZ_LN832404.1 # SIMILARITY Contains 1 sigma-54 factor interaction domain. {ECO:0000255|PROSITE-ProRule PRU00193}. # SMART SM00382 AAA # SUBCELLULAR LOCATION PSPF_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Forms a complex with PspA, which is composed of around 6 PspF subunits and 6 PspA subunits. {ECO:0000269|PubMed 19804784}. # SUPFAM SSF46689 SSF46689 # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR02974 phageshock_pspF # eggNOG COG1221 LUCA # eggNOG ENOG4105E51 Bacteria BLAST swissprot:PSPF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PSPF_ECOLI BioCyc ECOL316407:JW1296-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1296-MONOMER BioCyc EcoCyc:EG12344-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12344-MONOMER COG COG1221 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1221 DIP DIP-10592N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10592N DOI 10.1016/0022-2836(91)90379-K http://dx.doi.org/10.1016/0022-2836(91)90379-K DOI 10.1016/j.jmb.2009.09.055 http://dx.doi.org/10.1016/j.jmb.2009.09.055 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/ng0694-205 http://dx.doi.org/10.1038/ng0694-205 DOI 10.1074/jbc.M408994200 http://dx.doi.org/10.1074/jbc.M408994200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U38542 http://www.ebi.ac.uk/ena/data/view/U38542 EMBL X57560 http://www.ebi.ac.uk/ena/data/view/X57560 EchoBASE EB2248 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2248 EcoGene EG12344 http://www.ecogene.org/geneInfo.php?eg_id=EG12344 EnsemblBacteria AAC74385 http://www.ensemblgenomes.org/id/AAC74385 EnsemblBacteria AAC74385 http://www.ensemblgenomes.org/id/AAC74385 EnsemblBacteria BAA14872 http://www.ensemblgenomes.org/id/BAA14872 EnsemblBacteria BAA14872 http://www.ensemblgenomes.org/id/BAA14872 EnsemblBacteria BAA14872 http://www.ensemblgenomes.org/id/BAA14872 EnsemblBacteria b1303 http://www.ensemblgenomes.org/id/b1303 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945683 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945683 HOGENOM HOG000058487 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000058487&db=HOGENOM6 InParanoid P37344 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37344 IntAct P37344 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37344* InterPro IPR002078 http://www.ebi.ac.uk/interpro/entry/IPR002078 InterPro IPR002197 http://www.ebi.ac.uk/interpro/entry/IPR002197 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR014317 http://www.ebi.ac.uk/interpro/entry/IPR014317 InterPro IPR025943 http://www.ebi.ac.uk/interpro/entry/IPR025943 InterPro IPR025944 http://www.ebi.ac.uk/interpro/entry/IPR025944 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW1296 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1296 KEGG_Gene eco:b1303 http://www.genome.jp/dbget-bin/www_bget?eco:b1303 KEGG_Orthology KO:K03974 http://www.genome.jp/dbget-bin/www_bget?KO:K03974 OMA QTEKYEM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QTEKYEM PDB 2BJV http://www.ebi.ac.uk/pdbe-srv/view/entry/2BJV PDB 2BJW http://www.ebi.ac.uk/pdbe-srv/view/entry/2BJW PDB 2C96 http://www.ebi.ac.uk/pdbe-srv/view/entry/2C96 PDB 2C98 http://www.ebi.ac.uk/pdbe-srv/view/entry/2C98 PDB 2C99 http://www.ebi.ac.uk/pdbe-srv/view/entry/2C99 PDB 2C9C http://www.ebi.ac.uk/pdbe-srv/view/entry/2C9C PDB 2VII http://www.ebi.ac.uk/pdbe-srv/view/entry/2VII PDB 4QNM http://www.ebi.ac.uk/pdbe-srv/view/entry/4QNM PDB 4QNR http://www.ebi.ac.uk/pdbe-srv/view/entry/4QNR PDB 4QOS http://www.ebi.ac.uk/pdbe-srv/view/entry/4QOS PDBsum 2BJV http://www.ebi.ac.uk/pdbsum/2BJV PDBsum 2BJW http://www.ebi.ac.uk/pdbsum/2BJW PDBsum 2C96 http://www.ebi.ac.uk/pdbsum/2C96 PDBsum 2C98 http://www.ebi.ac.uk/pdbsum/2C98 PDBsum 2C99 http://www.ebi.ac.uk/pdbsum/2C99 PDBsum 2C9C http://www.ebi.ac.uk/pdbsum/2C9C PDBsum 2VII http://www.ebi.ac.uk/pdbsum/2VII PDBsum 4QNM http://www.ebi.ac.uk/pdbsum/4QNM PDBsum 4QNR http://www.ebi.ac.uk/pdbsum/4QNR PDBsum 4QOS http://www.ebi.ac.uk/pdbsum/4QOS PRINTS PR01590 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01590 PROSITE PS00676 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00676 PROSITE PS00688 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00688 PROSITE PS50045 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50045 PSORT swissprot:PSPF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PSPF_ECOLI PSORT-B swissprot:PSPF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PSPF_ECOLI PSORT2 swissprot:PSPF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PSPF_ECOLI Pfam PF00158 http://pfam.xfam.org/family/PF00158 Pfam PF02954 http://pfam.xfam.org/family/PF02954 Phobius swissprot:PSPF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PSPF_ECOLI PhylomeDB P37344 http://phylomedb.org/?seqid=P37344 ProteinModelPortal P37344 http://www.proteinmodelportal.org/query/uniprot/P37344 PubMed 15485810 http://www.ncbi.nlm.nih.gov/pubmed/15485810 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1712397 http://www.ncbi.nlm.nih.gov/pubmed/1712397 PubMed 19804784 http://www.ncbi.nlm.nih.gov/pubmed/19804784 PubMed 7920643 http://www.ncbi.nlm.nih.gov/pubmed/7920643 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 8606168 http://www.ncbi.nlm.nih.gov/pubmed/8606168 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415819 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415819 RefSeq WP_001301108 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001301108 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P37344 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37344 STRING 511145.b1303 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1303&targetmode=cogs STRING COG1221 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1221&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR02974 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02974 UniProtKB PSPF_ECOLI http://www.uniprot.org/uniprot/PSPF_ECOLI UniProtKB-AC P37344 http://www.uniprot.org/uniprot/P37344 charge swissprot:PSPF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PSPF_ECOLI eggNOG COG1221 http://eggnogapi.embl.de/nog_data/html/tree/COG1221 eggNOG ENOG4105E51 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E51 epestfind swissprot:PSPF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PSPF_ECOLI garnier swissprot:PSPF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PSPF_ECOLI helixturnhelix swissprot:PSPF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PSPF_ECOLI hmoment swissprot:PSPF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PSPF_ECOLI iep swissprot:PSPF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PSPF_ECOLI inforesidue swissprot:PSPF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PSPF_ECOLI octanol swissprot:PSPF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PSPF_ECOLI pepcoil swissprot:PSPF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PSPF_ECOLI pepdigest swissprot:PSPF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PSPF_ECOLI pepinfo swissprot:PSPF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PSPF_ECOLI pepnet swissprot:PSPF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PSPF_ECOLI pepstats swissprot:PSPF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PSPF_ECOLI pepwheel swissprot:PSPF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PSPF_ECOLI pepwindow swissprot:PSPF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PSPF_ECOLI sigcleave swissprot:PSPF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PSPF_ECOLI ## Database ID URL or Descriptions # AltName GLGA_ECOLI Starch [bacterial glycogen] synthase # BRENDA 2.4.1.21 2026 # BioGrid 4262501 323 # CATALYTIC ACTIVITY GLGA_ECOLI ADP-glucose + (1,4-alpha-D-glucosyl)(n) = ADP + (1,4-alpha-D-glucosyl)(n+1). # EcoGene EG10377 glgA # FUNCTION GLGA_ECOLI Synthesizes alpha-1,4-glucan chains using ADP-glucose. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004373 glycogen (starch) synthase activity; IEA:InterPro. # GO_function GO:0009011 starch synthase activity; IDA:EcoCyc. # GO_function GO:0033201 alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC. # GO_process GO:0005978 glycogen biosynthetic process; IMP:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # HAMAP MF_00484 Glycogen_synth # InterPro IPR001296 Glyco_trans_1 # InterPro IPR011835 GS/SS # InterPro IPR013534 Starch_synth_cat_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01003 Glycosyltransferases # KEGG_Pathway ko00500 Starch and sucrose metabolism # Organism GLGA_ECOLI Escherichia coli (strain K12) # PATHWAY GLGA_ECOLI Glycan biosynthesis; glycogen biosynthesis. # PATRIC 32122298 VBIEscCol129921_3526 # PDB 2QZS X-ray; 2.20 A; A=1-477 # PDB 2R4T X-ray; 2.26 A; A=1-477 # PDB 2R4U X-ray; 2.37 A; A=1-477 # PDB 3COP X-ray; 2.30 A; A=1-477 # PDB 3CX4 X-ray; 2.29 A; A=1-477 # PDB 3D1J X-ray; 3.00 A; A=1-477 # PDB 3GUH X-ray; 2.79 A; A=1-477 # PIR H65138 SYECGL # Pfam PF00534 Glycos_transf_1 # Pfam PF08323 Glyco_transf_5 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLGA_ECOLI Glycogen synthase # RefSeq NP_417887 NC_000913.3 # RefSeq WP_001197646 NZ_LN832404.1 # SIMILARITY Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily. {ECO 0000305}. # TIGRFAMs TIGR02095 glgA # eggNOG COG0297 LUCA # eggNOG ENOG4105CXW Bacteria BLAST swissprot:GLGA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLGA_ECOLI BioCyc ECOL316407:JW3392-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3392-MONOMER BioCyc EcoCyc:GLYCOGENSYN-MONOMER http://biocyc.org/getid?id=EcoCyc:GLYCOGENSYN-MONOMER BioCyc MetaCyc:GLYCOGENSYN-MONOMER http://biocyc.org/getid?id=MetaCyc:GLYCOGENSYN-MONOMER COG COG0297 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0297 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.4.1.21 http://www.genome.jp/dbget-bin/www_bget?EC:2.4.1.21 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01616 http://www.ebi.ac.uk/ena/data/view/J01616 EMBL J02616 http://www.ebi.ac.uk/ena/data/view/J02616 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL V00281 http://www.ebi.ac.uk/ena/data/view/V00281 ENZYME 2.4.1.21 http://enzyme.expasy.org/EC/2.4.1.21 EchoBASE EB0372 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0372 EcoGene EG10377 http://www.ecogene.org/geneInfo.php?eg_id=EG10377 EnsemblBacteria AAC76454 http://www.ensemblgenomes.org/id/AAC76454 EnsemblBacteria AAC76454 http://www.ensemblgenomes.org/id/AAC76454 EnsemblBacteria BAE77863 http://www.ensemblgenomes.org/id/BAE77863 EnsemblBacteria BAE77863 http://www.ensemblgenomes.org/id/BAE77863 EnsemblBacteria BAE77863 http://www.ensemblgenomes.org/id/BAE77863 EnsemblBacteria b3429 http://www.ensemblgenomes.org/id/b3429 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004373 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004373 GO_function GO:0009011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009011 GO_function GO:0033201 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033201 GO_process GO:0005978 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005978 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 947932 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947932 HAMAP MF_00484 http://hamap.expasy.org/unirule/MF_00484 HOGENOM HOG000294941 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000294941&db=HOGENOM6 InParanoid P0A6U8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6U8 IntAct P0A6U8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6U8* IntEnz 2.4.1.21 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.1.21 InterPro IPR001296 http://www.ebi.ac.uk/interpro/entry/IPR001296 InterPro IPR011835 http://www.ebi.ac.uk/interpro/entry/IPR011835 InterPro IPR013534 http://www.ebi.ac.uk/interpro/entry/IPR013534 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01003 http://www.genome.jp/dbget-bin/www_bget?ko01003 KEGG_Gene ecj:JW3392 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3392 KEGG_Gene eco:b3429 http://www.genome.jp/dbget-bin/www_bget?eco:b3429 KEGG_Orthology KO:K00703 http://www.genome.jp/dbget-bin/www_bget?KO:K00703 KEGG_Pathway ko00500 http://www.genome.jp/kegg-bin/show_pathway?ko00500 KEGG_Reaction rn:R02421 http://www.genome.jp/dbget-bin/www_bget?rn:R02421 OMA LLNAMRC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LLNAMRC PDB 2QZS http://www.ebi.ac.uk/pdbe-srv/view/entry/2QZS PDB 2R4T http://www.ebi.ac.uk/pdbe-srv/view/entry/2R4T PDB 2R4U http://www.ebi.ac.uk/pdbe-srv/view/entry/2R4U PDB 3COP http://www.ebi.ac.uk/pdbe-srv/view/entry/3COP PDB 3CX4 http://www.ebi.ac.uk/pdbe-srv/view/entry/3CX4 PDB 3D1J http://www.ebi.ac.uk/pdbe-srv/view/entry/3D1J PDB 3GUH http://www.ebi.ac.uk/pdbe-srv/view/entry/3GUH PDBsum 2QZS http://www.ebi.ac.uk/pdbsum/2QZS PDBsum 2R4T http://www.ebi.ac.uk/pdbsum/2R4T PDBsum 2R4U http://www.ebi.ac.uk/pdbsum/2R4U PDBsum 3COP http://www.ebi.ac.uk/pdbsum/3COP PDBsum 3CX4 http://www.ebi.ac.uk/pdbsum/3CX4 PDBsum 3D1J http://www.ebi.ac.uk/pdbsum/3D1J PDBsum 3GUH http://www.ebi.ac.uk/pdbsum/3GUH PSORT swissprot:GLGA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLGA_ECOLI PSORT-B swissprot:GLGA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLGA_ECOLI PSORT2 swissprot:GLGA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLGA_ECOLI Pfam PF00534 http://pfam.xfam.org/family/PF00534 Pfam PF08323 http://pfam.xfam.org/family/PF08323 Phobius swissprot:GLGA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLGA_ECOLI PhylomeDB P0A6U8 http://phylomedb.org/?seqid=P0A6U8 ProteinModelPortal P0A6U8 http://www.proteinmodelportal.org/query/uniprot/P0A6U8 PubMed 1644773 http://www.ncbi.nlm.nih.gov/pubmed/1644773 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3097003 http://www.ncbi.nlm.nih.gov/pubmed/3097003 PubMed 6300111 http://www.ncbi.nlm.nih.gov/pubmed/6300111 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417887 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417887 RefSeq WP_001197646 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001197646 SMR P0A6U8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6U8 STRING 511145.b3429 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3429&targetmode=cogs STRING COG0297 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0297&targetmode=cogs TIGRFAMs TIGR02095 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02095 UniProtKB GLGA_ECOLI http://www.uniprot.org/uniprot/GLGA_ECOLI UniProtKB-AC P0A6U8 http://www.uniprot.org/uniprot/P0A6U8 charge swissprot:GLGA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLGA_ECOLI eggNOG COG0297 http://eggnogapi.embl.de/nog_data/html/tree/COG0297 eggNOG ENOG4105CXW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CXW epestfind swissprot:GLGA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLGA_ECOLI garnier swissprot:GLGA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLGA_ECOLI helixturnhelix swissprot:GLGA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLGA_ECOLI hmoment swissprot:GLGA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLGA_ECOLI iep swissprot:GLGA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLGA_ECOLI inforesidue swissprot:GLGA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLGA_ECOLI octanol swissprot:GLGA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLGA_ECOLI pepcoil swissprot:GLGA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLGA_ECOLI pepdigest swissprot:GLGA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLGA_ECOLI pepinfo swissprot:GLGA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLGA_ECOLI pepnet swissprot:GLGA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLGA_ECOLI pepstats swissprot:GLGA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLGA_ECOLI pepwheel swissprot:GLGA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLGA_ECOLI pepwindow swissprot:GLGA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLGA_ECOLI sigcleave swissprot:GLGA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLGA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260941 282 # CDD cd09030 DUF1425 # EcoGene EG13430 ycfL # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_process GO:0006950 response to stress # IntAct P75946 2 # InterPro IPR010824 DUF1425 # Organism YCFL_ECOLI Escherichia coli (strain K12) # PATRIC 32117451 VBIEscCol129921_1148 # PIR E64854 E64854 # Pfam PF07233 DUF1425 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCFL_ECOLI Uncharacterized protein YcfL # RefSeq NP_415622 NC_000913.3 # RefSeq WP_001225295 NZ_LN832404.1 # eggNOG COG5633 LUCA # eggNOG ENOG41090DQ Bacteria BLAST swissprot:YCFL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCFL_ECOLI BioCyc ECOL316407:JW1090-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1090-MONOMER BioCyc EcoCyc:G6564-MONOMER http://biocyc.org/getid?id=EcoCyc:G6564-MONOMER DIP DIP-11540N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11540N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3204 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3204 EcoGene EG13430 http://www.ecogene.org/geneInfo.php?eg_id=EG13430 EnsemblBacteria AAC74188 http://www.ensemblgenomes.org/id/AAC74188 EnsemblBacteria AAC74188 http://www.ensemblgenomes.org/id/AAC74188 EnsemblBacteria BAA35911 http://www.ensemblgenomes.org/id/BAA35911 EnsemblBacteria BAA35911 http://www.ensemblgenomes.org/id/BAA35911 EnsemblBacteria BAA35911 http://www.ensemblgenomes.org/id/BAA35911 EnsemblBacteria b1104 http://www.ensemblgenomes.org/id/b1104 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 948539 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948539 HOGENOM HOG000119073 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000119073&db=HOGENOM6 IntAct P75946 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75946* InterPro IPR010824 http://www.ebi.ac.uk/interpro/entry/IPR010824 KEGG_Gene ecj:JW1090 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1090 KEGG_Gene eco:b1104 http://www.genome.jp/dbget-bin/www_bget?eco:b1104 MINT MINT-1305880 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1305880 OMA HYRYYWY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HYRYYWY PSORT swissprot:YCFL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCFL_ECOLI PSORT-B swissprot:YCFL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCFL_ECOLI PSORT2 swissprot:YCFL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCFL_ECOLI Pfam PF07233 http://pfam.xfam.org/family/PF07233 Phobius swissprot:YCFL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCFL_ECOLI ProteinModelPortal P75946 http://www.proteinmodelportal.org/query/uniprot/P75946 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415622 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415622 RefSeq WP_001225295 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001225295 SMR P75946 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75946 STRING 511145.b1104 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1104&targetmode=cogs UniProtKB YCFL_ECOLI http://www.uniprot.org/uniprot/YCFL_ECOLI UniProtKB-AC P75946 http://www.uniprot.org/uniprot/P75946 charge swissprot:YCFL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCFL_ECOLI eggNOG COG5633 http://eggnogapi.embl.de/nog_data/html/tree/COG5633 eggNOG ENOG41090DQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG41090DQ epestfind swissprot:YCFL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCFL_ECOLI garnier swissprot:YCFL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCFL_ECOLI helixturnhelix swissprot:YCFL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCFL_ECOLI hmoment swissprot:YCFL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCFL_ECOLI iep swissprot:YCFL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCFL_ECOLI inforesidue swissprot:YCFL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCFL_ECOLI octanol swissprot:YCFL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCFL_ECOLI pepcoil swissprot:YCFL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCFL_ECOLI pepdigest swissprot:YCFL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCFL_ECOLI pepinfo swissprot:YCFL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCFL_ECOLI pepnet swissprot:YCFL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCFL_ECOLI pepstats swissprot:YCFL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCFL_ECOLI pepwheel swissprot:YCFL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCFL_ECOLI pepwindow swissprot:YCFL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCFL_ECOLI sigcleave swissprot:YCFL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCFL_ECOLI ## Database ID URL or Descriptions # AltName Lipopolysaccharide regulatory protein {ECO:0000255|HAMAP-Rule MF_00994} # BioGrid 4259400 42 # DISRUPTION PHENOTYPE LAPB_ECOLI Deletion leads to changes in cell morphology and to the formation of bulges that contain cytoplasmic material and cause cell lysis. Mutants exhibit increased sensitivity to rifampicin and novobiocin, and to a mixture of SDS and EDTA. Growth is severely affected by osmolarity and temperature (PubMed 24187084). Mutant accumulates precursor forms of LPS and exhibits elevated levels of LpxC (PubMed 24722986). {ECO 0000269|PubMed 24187084, ECO 0000269|PubMed 24722986}. # DOMAIN LAPB_ECOLI The membrane anchor N-terminal domain is required for activity. The iron-binding domain is required for protein stability and function. {ECO 0000269|PubMed 24187084}. # EcoGene EG12691 yciM # FUNCTION LAPB_ECOLI Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane. {ECO 0000255|HAMAP-Rule MF_00994, ECO 0000269|PubMed 24266962, ECO 0000269|PubMed 24722986}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane; IEA:UniProtKB-HAMAP. # GO_function GO:0005506 iron ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0046872 metal ion binding; IDA:EcoCyc. # GO_process GO:0008653 lipopolysaccharide metabolic process; IPI:EcoCyc. # GO_process GO:0046890 regulation of lipid biosynthetic process; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0008150 biological_process # Gene3D 1.25.40.10 -; 3. # HAMAP MF_00994 LPS_assembly_LapB # INDUCTION LAPB_ECOLI Induced by heat shock, via RpoH. {ECO 0000269|PubMed 24266962, ECO 0000269|PubMed 24722986}. # InterPro IPR011990 TPR-like_helical_dom # InterPro IPR013026 TPR-contain_dom # InterPro IPR019734 TPR_repeat # InterPro IPR030865 LapB # Organism LAPB_ECOLI Escherichia coli (strain K12) # PATRIC 32117822 VBIEscCol129921_1331 # PIR C64876 C64876 # PROSITE PS50005 TPR; 6 # PROSITE PS50293 TPR_REGION # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LAPB_ECOLI Lipopolysaccharide assembly protein B {ECO 0000255|HAMAP-Rule MF_00994, ECO 0000303|PubMed 24722986} # RefSeq NP_415796 NC_000913.3 # RefSeq WP_000891353 NZ_LN832404.1 # SIMILARITY Belongs to the LapB family. {ECO:0000255|HAMAP- Rule MF_00994, ECO:0000305}. # SIMILARITY Contains 7 TPR repeats. {ECO:0000255|HAMAP- Rule MF_00994}. # SMART SM00028 TPR; 5 # SUBCELLULAR LOCATION LAPB_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_00994, ECO 0000269|PubMed 24187084, ECO 0000269|PubMed 24722986}; Single-pass membrane protein {ECO 0000255|HAMAP-Rule MF_00994, ECO 0000269|PubMed 24187084}; Cytoplasmic side {ECO 0000255|HAMAP-Rule MF_00994, ECO 0000269|PubMed 24187084}. # SUPFAM SSF48452 SSF48452; 2 # eggNOG COG2956 LUCA # eggNOG ENOG4105CFV Bacteria BLAST swissprot:LAPB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LAPB_ECOLI BioCyc ECOL316407:JW1272-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1272-MONOMER BioCyc EcoCyc:EG12691-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12691-MONOMER DIP DIP-48161N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48161N DOI 10.1016/0092-8674(88)90033-5 http://dx.doi.org/10.1016/0092-8674(88)90033-5 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M113.539494 http://dx.doi.org/10.1074/jbc.M113.539494 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1111/mmi.12452 http://dx.doi.org/10.1111/mmi.12452 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00921-13 http://dx.doi.org/10.1128/JB.00921-13 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M23250 http://www.ebi.ac.uk/ena/data/view/M23250 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2554 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2554 EcoGene EG12691 http://www.ecogene.org/geneInfo.php?eg_id=EG12691 EnsemblBacteria AAC74362 http://www.ensemblgenomes.org/id/AAC74362 EnsemblBacteria AAC74362 http://www.ensemblgenomes.org/id/AAC74362 EnsemblBacteria BAA14834 http://www.ensemblgenomes.org/id/BAA14834 EnsemblBacteria BAA14834 http://www.ensemblgenomes.org/id/BAA14834 EnsemblBacteria BAA14834 http://www.ensemblgenomes.org/id/BAA14834 EnsemblBacteria b1280 http://www.ensemblgenomes.org/id/b1280 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0031235 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031235 GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0008653 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008653 GO_process GO:0046890 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046890 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.25.40.10 http://www.cathdb.info/version/latest/superfamily/1.25.40.10 GeneID 944858 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944858 HAMAP MF_00994 http://hamap.expasy.org/unirule/MF_00994 HOGENOM HOG000257806 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000257806&db=HOGENOM6 InParanoid P0AB58 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AB58 IntAct P0AB58 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AB58* InterPro IPR011990 http://www.ebi.ac.uk/interpro/entry/IPR011990 InterPro IPR013026 http://www.ebi.ac.uk/interpro/entry/IPR013026 InterPro IPR019734 http://www.ebi.ac.uk/interpro/entry/IPR019734 InterPro IPR030865 http://www.ebi.ac.uk/interpro/entry/IPR030865 KEGG_Gene ecj:JW1272 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1272 KEGG_Gene eco:b1280 http://www.genome.jp/dbget-bin/www_bget?eco:b1280 OMA RYRCAAC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RYRCAAC PROSITE PS50005 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50005 PROSITE PS50293 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50293 PSORT swissprot:LAPB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LAPB_ECOLI PSORT-B swissprot:LAPB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LAPB_ECOLI PSORT2 swissprot:LAPB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LAPB_ECOLI Phobius swissprot:LAPB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LAPB_ECOLI PhylomeDB P0AB58 http://phylomedb.org/?seqid=P0AB58 ProteinModelPortal P0AB58 http://www.proteinmodelportal.org/query/uniprot/P0AB58 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 24187084 http://www.ncbi.nlm.nih.gov/pubmed/24187084 PubMed 24266962 http://www.ncbi.nlm.nih.gov/pubmed/24266962 PubMed 24722986 http://www.ncbi.nlm.nih.gov/pubmed/24722986 PubMed 3052852 http://www.ncbi.nlm.nih.gov/pubmed/3052852 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415796 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415796 RefSeq WP_000891353 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000891353 SMART SM00028 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00028 SMR P0AB58 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AB58 STRING 511145.b1280 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1280&targetmode=cogs SUPFAM SSF48452 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48452 UniProtKB LAPB_ECOLI http://www.uniprot.org/uniprot/LAPB_ECOLI UniProtKB-AC P0AB58 http://www.uniprot.org/uniprot/P0AB58 charge swissprot:LAPB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LAPB_ECOLI eggNOG COG2956 http://eggnogapi.embl.de/nog_data/html/tree/COG2956 eggNOG ENOG4105CFV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CFV epestfind swissprot:LAPB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LAPB_ECOLI garnier swissprot:LAPB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LAPB_ECOLI helixturnhelix swissprot:LAPB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LAPB_ECOLI hmoment swissprot:LAPB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LAPB_ECOLI iep swissprot:LAPB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LAPB_ECOLI inforesidue swissprot:LAPB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LAPB_ECOLI octanol swissprot:LAPB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LAPB_ECOLI pepcoil swissprot:LAPB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LAPB_ECOLI pepdigest swissprot:LAPB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LAPB_ECOLI pepinfo swissprot:LAPB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LAPB_ECOLI pepnet swissprot:LAPB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LAPB_ECOLI pepstats swissprot:LAPB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LAPB_ECOLI pepwheel swissprot:LAPB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LAPB_ECOLI pepwindow swissprot:LAPB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LAPB_ECOLI sigcleave swissprot:LAPB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LAPB_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES RTCA_ECOLI Kinetic parameters KM=20 uM for ATP {ECO 0000269|PubMed 9738023}; KM=100 uM for GTP {ECO 0000269|PubMed 9738023}; pH dependence Optimum pH is 8.0-8.5. {ECO 0000269|PubMed 9738023}; # BRENDA 6.5.1 2026 # BioGrid 4261186 4 # CATALYTIC ACTIVITY RTCA_ECOLI ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate. {ECO 0000269|PubMed 20399182, ECO 0000269|PubMed 9738023}. # DISRUPTION PHENOTYPE Disruption of the rtcA gene does not affect growth. {ECO:0000269|PubMed 9738023}. # EcoGene EG12938 rtcA # FUNCTION RTCA_ECOLI Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA- N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'- phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing. {ECO 0000269|PubMed 9738023}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003723 RNA binding; IBA:GO_Central. # GO_function GO:0003963 RNA-3'-phosphate cyclase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0006396 RNA processing; IEA:InterPro. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.30.360.20 -; 1. # Gene3D 3.65.10.20 -; 2. # HAMAP MF_00200 RTC # InterPro IPR000228 RNA3'_term_phos_cyc # InterPro IPR013791 RNA3'-term_phos_cycl_insert # InterPro IPR013792 RNA3'P_cycl/enolpyr_Trfase_a/b # InterPro IPR017770 RNA3'_term_phos_cyc_type_1 # InterPro IPR020719 RNA3'_term_phos_cycl-like_CS # InterPro IPR023797 RNA3'_phos_cyclase_dom # KEGG_Brite ko01000 Enzymes # MISCELLANEOUS RTCA_ECOLI RtcA (apo form) crystallized as a disulfide-linked homodimer via Cys-307 (PubMed 10673421) but the covalent RtcA-AMP catalytic intermediate crystallized as a monomer with the shortest distance between Cys-307 side chains of neighboring protomers being 41 Angstroms (PubMed 20399182). {ECO 0000305|PubMed 10673421, ECO 0000305|PubMed 20399182}. # Organism RTCA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11096 PTHR11096 # PANTHER PTHR11096:SF0 PTHR11096:SF0 # PATRIC 32122276 VBIEscCol129921_3515 # PDB 1QMH X-ray; 2.10 A; A/B=2-338 # PDB 1QMI X-ray; 2.80 A; A/B/C/D=2-338 # PDB 3KGD X-ray; 1.68 A; A/B/C/D=1-338 # PDB 3TUT X-ray; 1.58 A; A=1-338 # PDB 3TUX X-ray; 1.85 A; A=1-338 # PDB 3TV1 X-ray; 1.90 A; A/B=1-338 # PDB 3TW3 X-ray; 2.10 A; A=1-338 # PIRSF PIRSF005378 RNA3'_term_phos_cycl_euk # PROSITE PS01287 RTC # Pfam PF01137 RTC # Pfam PF05189 RTC_insert # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RTCA_ECOLI RNA 3'-terminal phosphate cyclase # RefSeq WP_001335950 NZ_LN832404.1 # RefSeq YP_026219 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA58217.1; Type=Frameshift; Positions=122; Note=Produces two separate ORFs.; Evidence={ECO:0000305}; Sequence=AAA58218.1; Type=Frameshift; Positions=122; Note=Produces two separate ORFs.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION RTCA_ECOLI Cytoplasm. # SUPFAM SSF52913 SSF52913 # SUPFAM SSF55205 SSF55205; 2 # TIGRFAMs TIGR03399 RNA_3prim_cycl # eggNOG COG0430 LUCA # eggNOG ENOG4105CKX Bacteria BLAST swissprot:RTCA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RTCA_ECOLI BioCyc ECOL316407:JW5688-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5688-MONOMER BioCyc EcoCyc:G7750-MONOMER http://biocyc.org/getid?id=EcoCyc:G7750-MONOMER BioCyc MetaCyc:G7750-MONOMER http://biocyc.org/getid?id=MetaCyc:G7750-MONOMER COG COG0430 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0430 DOI 10.1016/0378-1119(86)90297-0 http://dx.doi.org/10.1016/0378-1119(86)90297-0 DOI 10.1016/S0969-2126(00)00076-9 http://dx.doi.org/10.1016/S0969-2126(00)00076-9 DOI 10.1016/j.str.2010.01.016 http://dx.doi.org/10.1016/j.str.2010.01.016 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.273.39.25516 http://dx.doi.org/10.1074/jbc.273.39.25516 DOI 10.1093/emboj/16.10.2955 http://dx.doi.org/10.1093/emboj/16.10.2955 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.5.1.4 http://www.genome.jp/dbget-bin/www_bget?EC:6.5.1.4 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M13585 http://www.ebi.ac.uk/ena/data/view/M13585 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 6.5.1.4 http://enzyme.expasy.org/EC/6.5.1.4 EchoBASE EB2773 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2773 EcoGene EG12938 http://www.ecogene.org/geneInfo.php?eg_id=EG12938 EnsemblBacteria AAT48181 http://www.ensemblgenomes.org/id/AAT48181 EnsemblBacteria AAT48181 http://www.ensemblgenomes.org/id/AAT48181 EnsemblBacteria BAE77872 http://www.ensemblgenomes.org/id/BAE77872 EnsemblBacteria BAE77872 http://www.ensemblgenomes.org/id/BAE77872 EnsemblBacteria BAE77872 http://www.ensemblgenomes.org/id/BAE77872 EnsemblBacteria b4475 http://www.ensemblgenomes.org/id/b4475 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0003963 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003963 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006396 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006396 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.30.360.20 http://www.cathdb.info/version/latest/superfamily/3.30.360.20 Gene3D 3.65.10.20 http://www.cathdb.info/version/latest/superfamily/3.65.10.20 GeneID 2847707 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2847707 HAMAP MF_00200 http://hamap.expasy.org/unirule/MF_00200 HOGENOM HOG000015264 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000015264&db=HOGENOM6 InParanoid P46849 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P46849 IntEnz 6.5.1.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.5.1.4 InterPro IPR000228 http://www.ebi.ac.uk/interpro/entry/IPR000228 InterPro IPR013791 http://www.ebi.ac.uk/interpro/entry/IPR013791 InterPro IPR013792 http://www.ebi.ac.uk/interpro/entry/IPR013792 InterPro IPR017770 http://www.ebi.ac.uk/interpro/entry/IPR017770 InterPro IPR020719 http://www.ebi.ac.uk/interpro/entry/IPR020719 InterPro IPR023797 http://www.ebi.ac.uk/interpro/entry/IPR023797 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5688 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5688 KEGG_Gene eco:b4475 http://www.genome.jp/dbget-bin/www_bget?eco:b4475 KEGG_Orthology KO:K01974 http://www.genome.jp/dbget-bin/www_bget?KO:K01974 OMA NGCVDEF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NGCVDEF PANTHER PTHR11096 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11096 PANTHER PTHR11096:SF0 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11096:SF0 PDB 1QMH http://www.ebi.ac.uk/pdbe-srv/view/entry/1QMH PDB 1QMI http://www.ebi.ac.uk/pdbe-srv/view/entry/1QMI PDB 3KGD http://www.ebi.ac.uk/pdbe-srv/view/entry/3KGD PDB 3TUT http://www.ebi.ac.uk/pdbe-srv/view/entry/3TUT PDB 3TUX http://www.ebi.ac.uk/pdbe-srv/view/entry/3TUX PDB 3TV1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3TV1 PDB 3TW3 http://www.ebi.ac.uk/pdbe-srv/view/entry/3TW3 PDBsum 1QMH http://www.ebi.ac.uk/pdbsum/1QMH PDBsum 1QMI http://www.ebi.ac.uk/pdbsum/1QMI PDBsum 3KGD http://www.ebi.ac.uk/pdbsum/3KGD PDBsum 3TUT http://www.ebi.ac.uk/pdbsum/3TUT PDBsum 3TUX http://www.ebi.ac.uk/pdbsum/3TUX PDBsum 3TV1 http://www.ebi.ac.uk/pdbsum/3TV1 PDBsum 3TW3 http://www.ebi.ac.uk/pdbsum/3TW3 PROSITE PS01287 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01287 PSORT swissprot:RTCA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RTCA_ECOLI PSORT-B swissprot:RTCA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RTCA_ECOLI PSORT2 swissprot:RTCA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RTCA_ECOLI Pfam PF01137 http://pfam.xfam.org/family/PF01137 Pfam PF05189 http://pfam.xfam.org/family/PF05189 Phobius swissprot:RTCA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RTCA_ECOLI PhylomeDB P46849 http://phylomedb.org/?seqid=P46849 ProteinModelPortal P46849 http://www.proteinmodelportal.org/query/uniprot/P46849 PubMed 10673421 http://www.ncbi.nlm.nih.gov/pubmed/10673421 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20399182 http://www.ncbi.nlm.nih.gov/pubmed/20399182 PubMed 3015733 http://www.ncbi.nlm.nih.gov/pubmed/3015733 PubMed 9184239 http://www.ncbi.nlm.nih.gov/pubmed/9184239 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9738023 http://www.ncbi.nlm.nih.gov/pubmed/9738023 RefSeq WP_001335950 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001335950 RefSeq YP_026219 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026219 SMR P46849 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P46849 STRING 511145.b4475 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4475&targetmode=cogs STRING COG0430 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0430&targetmode=cogs SUPFAM SSF52913 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52913 SUPFAM SSF55205 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55205 TIGRFAMs TIGR03399 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03399 UniProtKB RTCA_ECOLI http://www.uniprot.org/uniprot/RTCA_ECOLI UniProtKB-AC P46849 http://www.uniprot.org/uniprot/P46849 charge swissprot:RTCA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RTCA_ECOLI eggNOG COG0430 http://eggnogapi.embl.de/nog_data/html/tree/COG0430 eggNOG ENOG4105CKX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CKX epestfind swissprot:RTCA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RTCA_ECOLI garnier swissprot:RTCA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RTCA_ECOLI helixturnhelix swissprot:RTCA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RTCA_ECOLI hmoment swissprot:RTCA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RTCA_ECOLI iep swissprot:RTCA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RTCA_ECOLI inforesidue swissprot:RTCA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RTCA_ECOLI octanol swissprot:RTCA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RTCA_ECOLI pepcoil swissprot:RTCA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RTCA_ECOLI pepdigest swissprot:RTCA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RTCA_ECOLI pepinfo swissprot:RTCA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RTCA_ECOLI pepnet swissprot:RTCA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RTCA_ECOLI pepstats swissprot:RTCA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RTCA_ECOLI pepwheel swissprot:RTCA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RTCA_ECOLI pepwindow swissprot:RTCA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RTCA_ECOLI sigcleave swissprot:RTCA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RTCA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262379 27 # EcoGene EG13013 yqhC # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_function GO:0043565 sequence-specific DNA binding; IEA:InterPro. # GO_function GO:0044212 transcription regulatory region DNA binding; IBA:GO_Central. # GO_process GO:0006351 transcription, DNA-templated; ISS:EcoCyc. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.60 -; 2. # IntAct Q46855 6 # InterPro IPR009057 Homeodomain-like # InterPro IPR009594 Tscrpt_reg_HTH_AraC_N # InterPro IPR018060 HTH_AraC # Organism YQHC_ECOLI Escherichia coli (strain K12) # PATRIC 32121434 VBIEscCol129921_3104 # PIR H65087 H65087 # PROSITE PS01124 HTH_ARAC_FAMILY_2 # Pfam PF06719 AraC_N # Pfam PF12833 HTH_18 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQHC_ECOLI Uncharacterized HTH-type transcriptional regulator YqhC # RefSeq NP_417483 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA69177.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Contains 1 HTH araC/xylS-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00593}. # SMART SM00342 HTH_ARAC # SUPFAM SSF46689 SSF46689; 2 # eggNOG ENOG4105CF7 Bacteria # eggNOG ENOG410XRKV LUCA BLAST swissprot:YQHC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQHC_ECOLI BioCyc ECOL316407:JW5849-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5849-MONOMER BioCyc EcoCyc:G7563-MONOMER http://biocyc.org/getid?id=EcoCyc:G7563-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2833 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2833 EcoGene EG13013 http://www.ecogene.org/geneInfo.php?eg_id=EG13013 EnsemblBacteria AAC76046 http://www.ensemblgenomes.org/id/AAC76046 EnsemblBacteria AAC76046 http://www.ensemblgenomes.org/id/AAC76046 EnsemblBacteria BAE77067 http://www.ensemblgenomes.org/id/BAE77067 EnsemblBacteria BAE77067 http://www.ensemblgenomes.org/id/BAE77067 EnsemblBacteria BAE77067 http://www.ensemblgenomes.org/id/BAE77067 EnsemblBacteria b3010 http://www.ensemblgenomes.org/id/b3010 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_function GO:0044212 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044212 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 GeneID 947491 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947491 HOGENOM HOG000203204 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000203204&db=HOGENOM6 InParanoid Q46855 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46855 IntAct Q46855 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46855* InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR009594 http://www.ebi.ac.uk/interpro/entry/IPR009594 InterPro IPR018060 http://www.ebi.ac.uk/interpro/entry/IPR018060 KEGG_Gene ecj:JW5849 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5849 KEGG_Gene eco:b3010 http://www.genome.jp/dbget-bin/www_bget?eco:b3010 OMA MYQPGIV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MYQPGIV PROSITE PS01124 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01124 PSORT swissprot:YQHC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQHC_ECOLI PSORT-B swissprot:YQHC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQHC_ECOLI PSORT2 swissprot:YQHC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQHC_ECOLI Pfam PF06719 http://pfam.xfam.org/family/PF06719 Pfam PF12833 http://pfam.xfam.org/family/PF12833 Phobius swissprot:YQHC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQHC_ECOLI PhylomeDB Q46855 http://phylomedb.org/?seqid=Q46855 ProteinModelPortal Q46855 http://www.proteinmodelportal.org/query/uniprot/Q46855 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417483 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417483 SMART SM00342 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00342 SMR Q46855 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46855 STRING 511145.b3010 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3010&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 UniProtKB YQHC_ECOLI http://www.uniprot.org/uniprot/YQHC_ECOLI UniProtKB-AC Q46855 http://www.uniprot.org/uniprot/Q46855 charge swissprot:YQHC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQHC_ECOLI eggNOG ENOG4105CF7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CF7 eggNOG ENOG410XRKV http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRKV epestfind swissprot:YQHC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQHC_ECOLI garnier swissprot:YQHC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQHC_ECOLI helixturnhelix swissprot:YQHC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQHC_ECOLI hmoment swissprot:YQHC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQHC_ECOLI iep swissprot:YQHC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQHC_ECOLI inforesidue swissprot:YQHC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQHC_ECOLI octanol swissprot:YQHC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQHC_ECOLI pepcoil swissprot:YQHC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQHC_ECOLI pepdigest swissprot:YQHC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQHC_ECOLI pepinfo swissprot:YQHC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQHC_ECOLI pepnet swissprot:YQHC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQHC_ECOLI pepstats swissprot:YQHC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQHC_ECOLI pepwheel swissprot:YQHC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQHC_ECOLI pepwindow swissprot:YQHC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQHC_ECOLI sigcleave swissprot:YQHC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQHC_ECOLI ## Database ID URL or Descriptions # BioGrid 4262632 9 # CDD cd07377 WHTH_GntR # EcoGene EG11838 yihL # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; ISS:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # Gene3D 3.40.1410.10 -; 1. # IntAct P0ACM9 9 # InterPro IPR000524 Tscrpt_reg_HTH_GntR # InterPro IPR011663 UTRA # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR028978 Chorismate_lyase_/UTRA_dom # Organism YIHL_ECOLI Escherichia coli (strain K12) # PATRIC 32123247 VBIEscCol129921_3984 # PIR S40817 S40817 # PRINTS PR00035 HTHGNTR # PROSITE PS50949 HTH_GNTR # Pfam PF00392 GntR # Pfam PF07702 UTRA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIHL_ECOLI Uncharacterized HTH-type transcriptional regulator YihL # RefSeq NP_418308 NC_000913.3 # RefSeq WP_000829798 NZ_LN832404.1 # SIMILARITY Contains 1 HTH gntR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00307}. # SMART SM00345 HTH_GNTR # SMART SM00866 UTRA # SUPFAM SSF46785 SSF46785 # SUPFAM SSF64288 SSF64288 # eggNOG COG2188 LUCA # eggNOG ENOG4108K85 Bacteria BLAST swissprot:YIHL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIHL_ECOLI BioCyc ECOL316407:JW3843-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3843-MONOMER BioCyc EcoCyc:EG11838-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11838-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1784 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1784 EcoGene EG11838 http://www.ecogene.org/geneInfo.php?eg_id=EG11838 EnsemblBacteria AAC76869 http://www.ensemblgenomes.org/id/AAC76869 EnsemblBacteria AAC76869 http://www.ensemblgenomes.org/id/AAC76869 EnsemblBacteria BAE77437 http://www.ensemblgenomes.org/id/BAE77437 EnsemblBacteria BAE77437 http://www.ensemblgenomes.org/id/BAE77437 EnsemblBacteria BAE77437 http://www.ensemblgenomes.org/id/BAE77437 EnsemblBacteria b3872 http://www.ensemblgenomes.org/id/b3872 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 3.40.1410.10 http://www.cathdb.info/version/latest/superfamily/3.40.1410.10 GeneID 948368 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948368 HOGENOM HOG000009654 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009654&db=HOGENOM6 InParanoid P0ACM9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACM9 IntAct P0ACM9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACM9* InterPro IPR000524 http://www.ebi.ac.uk/interpro/entry/IPR000524 InterPro IPR011663 http://www.ebi.ac.uk/interpro/entry/IPR011663 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR028978 http://www.ebi.ac.uk/interpro/entry/IPR028978 KEGG_Gene ecj:JW3843 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3843 KEGG_Gene eco:b3872 http://www.genome.jp/dbget-bin/www_bget?eco:b3872 OMA FYHETFI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FYHETFI PRINTS PR00035 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00035 PROSITE PS50949 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50949 PSORT swissprot:YIHL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIHL_ECOLI PSORT-B swissprot:YIHL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIHL_ECOLI PSORT2 swissprot:YIHL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIHL_ECOLI Pfam PF00392 http://pfam.xfam.org/family/PF00392 Pfam PF07702 http://pfam.xfam.org/family/PF07702 Phobius swissprot:YIHL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIHL_ECOLI PhylomeDB P0ACM9 http://phylomedb.org/?seqid=P0ACM9 ProteinModelPortal P0ACM9 http://www.proteinmodelportal.org/query/uniprot/P0ACM9 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418308 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418308 RefSeq WP_000829798 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000829798 SMART SM00345 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00345 SMART SM00866 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00866 SMR P0ACM9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACM9 STRING 511145.b3872 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3872&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SUPFAM SSF64288 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF64288 UniProtKB YIHL_ECOLI http://www.uniprot.org/uniprot/YIHL_ECOLI UniProtKB-AC P0ACM9 http://www.uniprot.org/uniprot/P0ACM9 charge swissprot:YIHL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIHL_ECOLI eggNOG COG2188 http://eggnogapi.embl.de/nog_data/html/tree/COG2188 eggNOG ENOG4108K85 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108K85 epestfind swissprot:YIHL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIHL_ECOLI garnier swissprot:YIHL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIHL_ECOLI helixturnhelix swissprot:YIHL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIHL_ECOLI hmoment swissprot:YIHL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIHL_ECOLI iep swissprot:YIHL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIHL_ECOLI inforesidue swissprot:YIHL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIHL_ECOLI octanol swissprot:YIHL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIHL_ECOLI pepcoil swissprot:YIHL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIHL_ECOLI pepdigest swissprot:YIHL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIHL_ECOLI pepinfo swissprot:YIHL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIHL_ECOLI pepnet swissprot:YIHL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIHL_ECOLI pepstats swissprot:YIHL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIHL_ECOLI pepwheel swissprot:YIHL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIHL_ECOLI pepwindow swissprot:YIHL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIHL_ECOLI sigcleave swissprot:YIHL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIHL_ECOLI ## Database ID URL or Descriptions # BioGrid 4260922 8 # CDD cd07046 BMC_PduU-EutS # EcoGene EG14192 eutS # FUNCTION EUTS_ECOLI May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place. # GO_component GO:0031471 ethanolamine degradation polyhedral organelle; ISS:EcoCyc. # GO_function GO:0005198 structural molecule activity; ISS:EcoCyc. # GO_process GO:0046336 ethanolamine catabolic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0043226 organelle # GOslim_function GO:0005198 structural molecule activity # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # IntAct P63746 9 # InterPro IPR000249 Microcompartment_bac # InterPro IPR009307 EutS # Organism EUTS_ECOLI Escherichia coli (strain K12) # PANTHER PTHR40449 PTHR40449 # PATHWAY EUTS_ECOLI Amine and polyamine degradation; ethanolamine degradation. # PATRIC 32120307 VBIEscCol129921_2556 # PDB 3I96 X-ray; 1.65 A; A/B/C=1-111 # PDB 3IA0 X-ray; 2.50 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X/Y/Z/a/b/c/d/e/f/g/h/i/j/k/l/m/n/o/p/q/r/s/t/u/v=1-111 # PIRSF PIRSF012296 EutS_PduU # Pfam PF00936 BMC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EUTS_ECOLI Ethanolamine utilization protein EutS # RefSeq NP_416957 NC_000913.3 # RefSeq WP_000356956 NZ_LN832404.1 # SIMILARITY Belongs to the EutS/PduU family. {ECO 0000305}. # SMART SM00877 BMC # eggNOG COG4810 LUCA # eggNOG ENOG4108VJN Bacteria BLAST swissprot:EUTS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EUTS_ECOLI BioCyc ECOL316407:JW2446-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2446-MONOMER BioCyc EcoCyc:G7292-MONOMER http://biocyc.org/getid?id=EcoCyc:G7292-MONOMER COG COG4810 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4810 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3944 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3944 EcoGene EG14192 http://www.ecogene.org/geneInfo.php?eg_id=EG14192 EnsemblBacteria AAC75515 http://www.ensemblgenomes.org/id/AAC75515 EnsemblBacteria AAC75515 http://www.ensemblgenomes.org/id/AAC75515 EnsemblBacteria BAE76720 http://www.ensemblgenomes.org/id/BAE76720 EnsemblBacteria BAE76720 http://www.ensemblgenomes.org/id/BAE76720 EnsemblBacteria BAE76720 http://www.ensemblgenomes.org/id/BAE76720 EnsemblBacteria b2462 http://www.ensemblgenomes.org/id/b2462 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0031471 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031471 GO_function GO:0005198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005198 GO_process GO:0046336 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046336 GOslim_component GO:0043226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226 GOslim_function GO:0005198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005198 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 946936 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946936 HOGENOM HOG000286280 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000286280&db=HOGENOM6 InParanoid P63746 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P63746 IntAct P63746 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P63746* InterPro IPR000249 http://www.ebi.ac.uk/interpro/entry/IPR000249 InterPro IPR009307 http://www.ebi.ac.uk/interpro/entry/IPR009307 KEGG_Gene ecj:JW2446 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2446 KEGG_Gene eco:b2462 http://www.genome.jp/dbget-bin/www_bget?eco:b2462 KEGG_Orthology KO:K04031 http://www.genome.jp/dbget-bin/www_bget?KO:K04031 OMA IIQESVP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IIQESVP PANTHER PTHR40449 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR40449 PDB 3I96 http://www.ebi.ac.uk/pdbe-srv/view/entry/3I96 PDB 3IA0 http://www.ebi.ac.uk/pdbe-srv/view/entry/3IA0 PDBsum 3I96 http://www.ebi.ac.uk/pdbsum/3I96 PDBsum 3IA0 http://www.ebi.ac.uk/pdbsum/3IA0 PSORT swissprot:EUTS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EUTS_ECOLI PSORT-B swissprot:EUTS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EUTS_ECOLI PSORT2 swissprot:EUTS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EUTS_ECOLI Pfam PF00936 http://pfam.xfam.org/family/PF00936 Phobius swissprot:EUTS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EUTS_ECOLI ProteinModelPortal P63746 http://www.proteinmodelportal.org/query/uniprot/P63746 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416957 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416957 RefSeq WP_000356956 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000356956 SMART SM00877 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00877 SMR P63746 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P63746 STRING 511145.b2462 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2462&targetmode=cogs STRING COG4810 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4810&targetmode=cogs UniProtKB EUTS_ECOLI http://www.uniprot.org/uniprot/EUTS_ECOLI UniProtKB-AC P63746 http://www.uniprot.org/uniprot/P63746 charge swissprot:EUTS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EUTS_ECOLI eggNOG COG4810 http://eggnogapi.embl.de/nog_data/html/tree/COG4810 eggNOG ENOG4108VJN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108VJN epestfind swissprot:EUTS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EUTS_ECOLI garnier swissprot:EUTS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EUTS_ECOLI helixturnhelix swissprot:EUTS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EUTS_ECOLI hmoment swissprot:EUTS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EUTS_ECOLI iep swissprot:EUTS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EUTS_ECOLI inforesidue swissprot:EUTS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EUTS_ECOLI octanol swissprot:EUTS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EUTS_ECOLI pepcoil swissprot:EUTS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EUTS_ECOLI pepdigest swissprot:EUTS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EUTS_ECOLI pepinfo swissprot:EUTS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EUTS_ECOLI pepnet swissprot:EUTS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EUTS_ECOLI pepstats swissprot:EUTS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EUTS_ECOLI pepwheel swissprot:EUTS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EUTS_ECOLI pepwindow swissprot:EUTS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EUTS_ECOLI sigcleave swissprot:EUTS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EUTS_ECOLI ## Database ID URL or Descriptions # BioGrid 4261133 134 # EcoGene EG14345 ecnB # FUNCTION ECNB_ECOLI Plays a role in the bacteriolysis. Is activated under conditions of high osmolarity by the factor sigma S. Entericidin A functions as an antidote. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016020 membrane; IDA:EcoCyc. # GO_process GO:0009636 response to toxic substance; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0008150 biological_process # InterPro IPR012556 Entericidin # KEGG_Brite ko02000 Transporters # Organism ECNB_ECOLI Escherichia coli (strain K12) # PATRIC 32123867 VBIEscCol129921_4281 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF08085 Entericidin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ECNB_ECOLI Entericidin B # RefSeq WP_000239596 NZ_LN832404.1 # RefSeq YP_026284 NC_000913.3 # SIMILARITY Belongs to the EcnA/EcnB lipoprotein family. {ECO 0000305}. # SUBCELLULAR LOCATION ECNB_ECOLI Cell membrane; Lipid-anchor. # TCDB 9.B.13.1 the putative pore-forming entericidin (ecn) family # eggNOG ENOG4106BSU Bacteria # eggNOG ENOG410Y4IR LUCA BLAST swissprot:ECNB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ECNB_ECOLI BioCyc ECOL316407:JW4108-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4108-MONOMER BioCyc EcoCyc:MONOMER0-1563 http://biocyc.org/getid?id=EcoCyc:MONOMER0-1563 DOI 10.1006/jmbi.1998.1894 http://dx.doi.org/10.1006/jmbi.1998.1894 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL U21726 http://www.ebi.ac.uk/ena/data/view/U21726 EchoBASE EB4091 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4091 EcoGene EG14345 http://www.ecogene.org/geneInfo.php?eg_id=EG14345 EnsemblBacteria AAT48242 http://www.ensemblgenomes.org/id/AAT48242 EnsemblBacteria AAT48242 http://www.ensemblgenomes.org/id/AAT48242 EnsemblBacteria BAE78151 http://www.ensemblgenomes.org/id/BAE78151 EnsemblBacteria BAE78151 http://www.ensemblgenomes.org/id/BAE78151 EnsemblBacteria BAE78151 http://www.ensemblgenomes.org/id/BAE78151 EnsemblBacteria b4411 http://www.ensemblgenomes.org/id/b4411 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_process GO:0009636 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009636 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 2847737 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2847737 HOGENOM HOG000211677 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000211677&db=HOGENOM6 InterPro IPR012556 http://www.ebi.ac.uk/interpro/entry/IPR012556 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW4108 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4108 KEGG_Gene eco:b4411 http://www.genome.jp/dbget-bin/www_bget?eco:b4411 KEGG_Orthology KO:K16348 http://www.genome.jp/dbget-bin/www_bget?KO:K16348 PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:ECNB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ECNB_ECOLI PSORT-B swissprot:ECNB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ECNB_ECOLI PSORT2 swissprot:ECNB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ECNB_ECOLI Pfam PF08085 http://pfam.xfam.org/family/PF08085 Phobius swissprot:ECNB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ECNB_ECOLI ProteinModelPortal P0ADB7 http://www.proteinmodelportal.org/query/uniprot/P0ADB7 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9677290 http://www.ncbi.nlm.nih.gov/pubmed/9677290 RefSeq WP_000239596 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000239596 RefSeq YP_026284 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026284 STRING 511145.b4411 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4411&targetmode=cogs TCDB 9.B.13.1 http://www.tcdb.org/search/result.php?tc=9.B.13.1 UniProtKB ECNB_ECOLI http://www.uniprot.org/uniprot/ECNB_ECOLI UniProtKB-AC P0ADB7 http://www.uniprot.org/uniprot/P0ADB7 charge swissprot:ECNB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ECNB_ECOLI eggNOG ENOG4106BSU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106BSU eggNOG ENOG410Y4IR http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y4IR epestfind swissprot:ECNB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ECNB_ECOLI garnier swissprot:ECNB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ECNB_ECOLI helixturnhelix swissprot:ECNB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ECNB_ECOLI hmoment swissprot:ECNB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ECNB_ECOLI iep swissprot:ECNB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ECNB_ECOLI inforesidue swissprot:ECNB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ECNB_ECOLI octanol swissprot:ECNB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ECNB_ECOLI pepcoil swissprot:ECNB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ECNB_ECOLI pepdigest swissprot:ECNB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ECNB_ECOLI pepinfo swissprot:ECNB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ECNB_ECOLI pepnet swissprot:ECNB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ECNB_ECOLI pepstats swissprot:ECNB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ECNB_ECOLI pepwheel swissprot:ECNB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ECNB_ECOLI pepwindow swissprot:ECNB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ECNB_ECOLI sigcleave swissprot:ECNB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ECNB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260388 6 # CATALYTIC ACTIVITY ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out). {ECO:0000255|PROSITE-ProRule PRU10106}. # EcoGene EG20266 fliI # FUNCTION FLII_ECOLI Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum. May be involved in a specialized protein export pathway that proceeds without signal peptide cleavage. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_component GO:0030257 type III protein secretion system complex; IEA:InterPro. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016887 ATPase activity; IEA:InterPro. # GO_process GO:0006754 ATP biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0015992 proton transport; IEA:UniProtKB-KW. # GO_process GO:0030254 protein secretion by the type III secretion system; IEA:InterPro. # GO_process GO:0044780 bacterial-type flagellum assembly; IEA:InterPro. # GO_process GO:0071973 bacterial-type flagellum-dependent cell motility; IEA:InterPro. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0048870 cell motility # GOslim_process GO:0055085 transmembrane transport # Gene3D 3.40.50.300 -; 1. # INTERACTION FLII_ECOLI Self; NbExp=4; IntAct=EBI-1118363, EBI-1118363; # IntAct P52612 23 # InterPro IPR000194 ATPase_F1/V1/A1_a/bsu_nucl-bd # InterPro IPR003593 AAA+_ATPase # InterPro IPR005714 ATPase_T3SS_FliI/YscN # InterPro IPR020003 ATPase_a/bsu_AS # InterPro IPR020005 FliI_clade1 # InterPro IPR027417 P-loop_NTPase # InterPro IPR032463 ATPase_T3SS_FliI # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko02040 Flagellar assembly # Organism FLII_ECOLI Escherichia coli (strain K12) # PANTHER PTHR15184:SF9 PTHR15184:SF9 # PATRIC 32119211 VBIEscCol129921_2020 # PIR B64958 B64958 # PROSITE PS00152 ATPASE_ALPHA_BETA # Pfam PF00006 ATP-synt_ab # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FLII_ECOLI Flagellum-specific ATP synthase # RefSeq NP_416451 NC_000913.3 # RefSeq WP_000213294 NZ_LN832404.1 # SIMILARITY Belongs to the ATPase alpha/beta chains family. {ECO 0000305}. # SMART SM00382 AAA # SUBCELLULAR LOCATION FLII_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR01026 fliI_yscN # TIGRFAMs TIGR03496 FliI_clade1 # eggNOG COG1157 LUCA # eggNOG ENOG4108JIR Bacteria BLAST swissprot:FLII_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLII_ECOLI BioCyc ECOL316407:JW1925-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1925-MONOMER BioCyc EcoCyc:G377-MONOMER http://biocyc.org/getid?id=EcoCyc:G377-MONOMER COG COG1157 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1157 DIP DIP-9655N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9655N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.3.14 http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.14 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L49147 http://www.ebi.ac.uk/ena/data/view/L49147 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.6.3.14 http://enzyme.expasy.org/EC/3.6.3.14 EchoBASE EB4163 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4163 EcoGene EG20266 http://www.ecogene.org/geneInfo.php?eg_id=EG20266 EnsemblBacteria AAC75008 http://www.ensemblgenomes.org/id/AAC75008 EnsemblBacteria AAC75008 http://www.ensemblgenomes.org/id/AAC75008 EnsemblBacteria BAA15766 http://www.ensemblgenomes.org/id/BAA15766 EnsemblBacteria BAA15766 http://www.ensemblgenomes.org/id/BAA15766 EnsemblBacteria BAA15766 http://www.ensemblgenomes.org/id/BAA15766 EnsemblBacteria b1941 http://www.ensemblgenomes.org/id/b1941 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0030257 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030257 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_process GO:0006754 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006754 GO_process GO:0015992 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015992 GO_process GO:0030254 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030254 GO_process GO:0044780 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044780 GO_process GO:0071973 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071973 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 946457 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946457 HOGENOM HOG000257876 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000257876&db=HOGENOM6 InParanoid P52612 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P52612 IntAct P52612 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P52612* IntEnz 3.6.3.14 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.14 InterPro IPR000194 http://www.ebi.ac.uk/interpro/entry/IPR000194 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR005714 http://www.ebi.ac.uk/interpro/entry/IPR005714 InterPro IPR020003 http://www.ebi.ac.uk/interpro/entry/IPR020003 InterPro IPR020005 http://www.ebi.ac.uk/interpro/entry/IPR020005 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR032463 http://www.ebi.ac.uk/interpro/entry/IPR032463 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW1925 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1925 KEGG_Gene eco:b1941 http://www.genome.jp/dbget-bin/www_bget?eco:b1941 KEGG_Orthology KO:K02412 http://www.genome.jp/dbget-bin/www_bget?KO:K02412 KEGG_Pathway ko02040 http://www.genome.jp/kegg-bin/show_pathway?ko02040 OMA QAQKFKQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QAQKFKQ PANTHER PTHR15184:SF9 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15184:SF9 PROSITE PS00152 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00152 PSORT swissprot:FLII_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLII_ECOLI PSORT-B swissprot:FLII_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLII_ECOLI PSORT2 swissprot:FLII_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLII_ECOLI Pfam PF00006 http://pfam.xfam.org/family/PF00006 Phobius swissprot:FLII_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLII_ECOLI PhylomeDB P52612 http://phylomedb.org/?seqid=P52612 ProteinModelPortal P52612 http://www.proteinmodelportal.org/query/uniprot/P52612 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416451 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416451 RefSeq WP_000213294 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000213294 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P52612 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P52612 STRING 511145.b1941 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1941&targetmode=cogs STRING COG1157 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1157&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR01026 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01026 TIGRFAMs TIGR03496 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03496 UniProtKB FLII_ECOLI http://www.uniprot.org/uniprot/FLII_ECOLI UniProtKB-AC P52612 http://www.uniprot.org/uniprot/P52612 charge swissprot:FLII_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLII_ECOLI eggNOG COG1157 http://eggnogapi.embl.de/nog_data/html/tree/COG1157 eggNOG ENOG4108JIR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108JIR epestfind swissprot:FLII_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLII_ECOLI garnier swissprot:FLII_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLII_ECOLI helixturnhelix swissprot:FLII_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLII_ECOLI hmoment swissprot:FLII_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLII_ECOLI iep swissprot:FLII_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLII_ECOLI inforesidue swissprot:FLII_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLII_ECOLI octanol swissprot:FLII_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLII_ECOLI pepcoil swissprot:FLII_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLII_ECOLI pepdigest swissprot:FLII_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLII_ECOLI pepinfo swissprot:FLII_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLII_ECOLI pepnet swissprot:FLII_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLII_ECOLI pepstats swissprot:FLII_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLII_ECOLI pepwheel swissprot:FLII_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLII_ECOLI pepwindow swissprot:FLII_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLII_ECOLI sigcleave swissprot:FLII_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLII_ECOLI ## Database ID URL or Descriptions # AltName Betaine aldehyde dehydrogenase {ECO:0000255|HAMAP-Rule MF_00750} # BIOPHYSICOCHEMICAL PROPERTIES BETA_ECOLI Kinetic parameters KM=0.06 mM for NAD (at pH 7.5 and 37 degrees Celsius) {ECO 0000269|PubMed 3512525}; KM=0.13 mM for glycine betaine aldehyde (at pH 7.5 and 37 degrees Celsius) {ECO 0000269|PubMed 3512525}; KM=0.5 mM for NADP (at pH 7.5 and 37 degrees Celsius) {ECO 0000269|PubMed 3512525}; KM=1.5 mM for choline (at pH 7.5 and 37 degrees Celsius) {ECO 0000269|PubMed 3512525}; KM=1.6 mM for glycine betaine aldehyde (at pH 7.5 and 37 degrees Celsius) {ECO 0000269|PubMed 3512525}; pH dependence Optimum pH is 7.5 for choline dehydrogenase and is between 7.5 and 9.5 for glycine betaine-aldehyde dehydrogenase. {ECO 0000269|PubMed 3512525}; # BioGrid 4262800 6 # CATALYTIC ACTIVITY BETA_ECOLI Betaine aldehyde + NAD(+) + H(2)O = betaine + NADH. {ECO 0000255|HAMAP-Rule MF_00750, ECO 0000269|PubMed 3512525}. # CATALYTIC ACTIVITY BETA_ECOLI Choline + acceptor = betaine aldehyde + reduced acceptor. {ECO 0000255|HAMAP-Rule MF_00750, ECO 0000269|PubMed 3512525}. # COFACTOR BETA_ECOLI Name=FAD; Xref=ChEBI CHEBI 57692; Evidence={ECO 0000255|HAMAP-Rule MF_00750}; # DISRUPTION PHENOTYPE Cells lacking this gene do not grow at high osmotic strength in the presence of choline, but are able to grow when the medium is supplemented with glycine betaine. {ECO:0000269|PubMed 3512526}. # ENZYME REGULATION Activated by high osmotic strength. {ECO:0000269|PubMed 3512525}. # EcoGene EG10109 betA # FUNCTION BETA_ECOLI Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate. {ECO 0000255|HAMAP-Rule MF_00750, ECO 0000269|PubMed 3512525, ECO 0000269|PubMed 3512526}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016020 membrane; IDA:EcoCyc. # GO_function GO:0008802 betaine-aldehyde dehydrogenase activity; IEA:UniProtKB-EC. # GO_function GO:0008812 choline dehydrogenase activity; IDA:EcoCyc. # GO_function GO:0050660 flavin adenine dinucleotide binding; IEA:InterPro. # GO_process GO:0006970 response to osmotic stress; IMP:EcoCyc. # GO_process GO:0019285 glycine betaine biosynthetic process from choline; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.50.50.60 -; 3. # HAMAP MF_00750 Choline_dehydrogen # INDUCTION BETA_ECOLI By osmotic stress. Choline is required for full expression. Oxygen and choline exert their control via the transacting DNA-binding proteins ArcA and BetI, respectively. {ECO 0000269|PubMed 3512525, ECO 0000269|PubMed 8626294}. # IntAct P17444 8 # InterPro IPR000172 GMC_OxRdtase_N # InterPro IPR007867 GMC_OxRtase_C # InterPro IPR011533 BetA # InterPro IPR012132 GMC_OxRdtase # InterPro IPR023753 FAD/NAD-binding_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00260 Glycine, serine and threonine metabolism # Organism BETA_ECOLI Escherichia coli (strain K12) # PATHWAY Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. {ECO 0000255|HAMAP-Rule:MF_00750}. # PATRIC 32115751 VBIEscCol129921_0318 # PIR S15182 S10901 # PIRSF PIRSF000137 Alcohol_oxidase # PROSITE PS00623 GMC_OXRED_1 # PROSITE PS00624 GMC_OXRED_2 # Pfam PF00732 GMC_oxred_N # Pfam PF05199 GMC_oxred_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Oxygen-dependent choline dehydrogenase {ECO:0000255|HAMAP-Rule MF_00750} # RefSeq NP_414845 NC_000913.3 # RefSeq WP_001159094 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18037.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the GMC oxidoreductase family. {ECO:0000255|HAMAP-Rule MF_00750}. # SUBCELLULAR LOCATION BETA_ECOLI Cell membrane {ECO 0000269|PubMed 3512525}; Peripheral membrane protein {ECO 0000269|PubMed 3512525}. # SUPFAM SSF51905 SSF51905; 2 # TIGRFAMs TIGR01810 betA # UniPathway UPA00529 UER00385 # eggNOG COG2303 LUCA # eggNOG ENOG4105CZ6 Bacteria BLAST swissprot:BETA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BETA_ECOLI BioCyc ECOL316407:JW0303-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0303-MONOMER BioCyc EcoCyc:CHD-MONOMER http://biocyc.org/getid?id=EcoCyc:CHD-MONOMER BioCyc MetaCyc:CHD-MONOMER http://biocyc.org/getid?id=MetaCyc:CHD-MONOMER COG COG2303 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2303 DOI 10.1016/0378-1119(91)90389-S http://dx.doi.org/10.1016/0378-1119(91)90389-S DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1991.tb01877.x http://dx.doi.org/10.1111/j.1365-2958.1991.tb01877.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.99.1 {ECO:0000255|HAMAP-Rule:MF_00750} http://www.genome.jp/dbget-bin/www_bget?EC:1.1.99.1 {ECO:0000255|HAMAP-Rule:MF_00750} EC_number EC:1.2.1.8 {ECO:0000255|HAMAP-Rule:MF_00750} http://www.genome.jp/dbget-bin/www_bget?EC:1.2.1.8 {ECO:0000255|HAMAP-Rule:MF_00750} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M77738 http://www.ebi.ac.uk/ena/data/view/M77738 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EMBL X52905 http://www.ebi.ac.uk/ena/data/view/X52905 ENZYME 1.1.99.1 {ECO:0000255|HAMAP-Rule:MF_00750} http://enzyme.expasy.org/EC/1.1.99.1 {ECO:0000255|HAMAP-Rule:MF_00750} ENZYME 1.2.1.8 {ECO:0000255|HAMAP-Rule:MF_00750} http://enzyme.expasy.org/EC/1.2.1.8 {ECO:0000255|HAMAP-Rule:MF_00750} EchoBASE EB0107 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0107 EcoGene EG10109 http://www.ecogene.org/geneInfo.php?eg_id=EG10109 EnsemblBacteria AAC73414 http://www.ensemblgenomes.org/id/AAC73414 EnsemblBacteria AAC73414 http://www.ensemblgenomes.org/id/AAC73414 EnsemblBacteria BAE76094 http://www.ensemblgenomes.org/id/BAE76094 EnsemblBacteria BAE76094 http://www.ensemblgenomes.org/id/BAE76094 EnsemblBacteria BAE76094 http://www.ensemblgenomes.org/id/BAE76094 EnsemblBacteria b0311 http://www.ensemblgenomes.org/id/b0311 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0008802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008802 GO_function GO:0008812 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008812 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_process GO:0006970 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006970 GO_process GO:0019285 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019285 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 GeneID 945716 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945716 HAMAP MF_00750 http://hamap.expasy.org/unirule/MF_00750 HOGENOM HOG000139600 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000139600&db=HOGENOM6 InParanoid P17444 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P17444 IntAct P17444 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P17444* IntEnz 1.1.99.1 {ECO:0000255|HAMAP-Rule:MF_00750} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.99.1 {ECO:0000255|HAMAP-Rule:MF_00750} IntEnz 1.2.1.8 {ECO:0000255|HAMAP-Rule:MF_00750} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.2.1.8 {ECO:0000255|HAMAP-Rule:MF_00750} InterPro IPR000172 http://www.ebi.ac.uk/interpro/entry/IPR000172 InterPro IPR007867 http://www.ebi.ac.uk/interpro/entry/IPR007867 InterPro IPR011533 http://www.ebi.ac.uk/interpro/entry/IPR011533 InterPro IPR012132 http://www.ebi.ac.uk/interpro/entry/IPR012132 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0303 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0303 KEGG_Gene eco:b0311 http://www.genome.jp/dbget-bin/www_bget?eco:b0311 KEGG_Orthology KO:K00108 http://www.genome.jp/dbget-bin/www_bget?KO:K00108 KEGG_Pathway ko00260 http://www.genome.jp/kegg-bin/show_pathway?ko00260 KEGG_Reaction rn:R01025 http://www.genome.jp/dbget-bin/www_bget?rn:R01025 OMA PREYPSI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PREYPSI PROSITE PS00623 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00623 PROSITE PS00624 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00624 PSORT swissprot:BETA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BETA_ECOLI PSORT-B swissprot:BETA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BETA_ECOLI PSORT2 swissprot:BETA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BETA_ECOLI Pfam PF00732 http://pfam.xfam.org/family/PF00732 Pfam PF05199 http://pfam.xfam.org/family/PF05199 Phobius swissprot:BETA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BETA_ECOLI PhylomeDB P17444 http://phylomedb.org/?seqid=P17444 ProteinModelPortal P17444 http://www.proteinmodelportal.org/query/uniprot/P17444 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1879697 http://www.ncbi.nlm.nih.gov/pubmed/1879697 PubMed 1956285 http://www.ncbi.nlm.nih.gov/pubmed/1956285 PubMed 3512525 http://www.ncbi.nlm.nih.gov/pubmed/3512525 PubMed 3512526 http://www.ncbi.nlm.nih.gov/pubmed/3512526 PubMed 8626294 http://www.ncbi.nlm.nih.gov/pubmed/8626294 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414845 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414845 RefSeq WP_001159094 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001159094 SMR P17444 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P17444 STRING 511145.b0311 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0311&targetmode=cogs STRING COG2303 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2303&targetmode=cogs SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 TIGRFAMs TIGR01810 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01810 UniProtKB BETA_ECOLI http://www.uniprot.org/uniprot/BETA_ECOLI UniProtKB-AC P17444 http://www.uniprot.org/uniprot/P17444 charge swissprot:BETA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BETA_ECOLI eggNOG COG2303 http://eggnogapi.embl.de/nog_data/html/tree/COG2303 eggNOG ENOG4105CZ6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CZ6 epestfind swissprot:BETA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BETA_ECOLI garnier swissprot:BETA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BETA_ECOLI helixturnhelix swissprot:BETA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BETA_ECOLI hmoment swissprot:BETA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BETA_ECOLI iep swissprot:BETA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BETA_ECOLI inforesidue swissprot:BETA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BETA_ECOLI octanol swissprot:BETA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BETA_ECOLI pepcoil swissprot:BETA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BETA_ECOLI pepdigest swissprot:BETA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BETA_ECOLI pepinfo swissprot:BETA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BETA_ECOLI pepnet swissprot:BETA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BETA_ECOLI pepstats swissprot:BETA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BETA_ECOLI pepwheel swissprot:BETA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BETA_ECOLI pepwindow swissprot:BETA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BETA_ECOLI sigcleave swissprot:BETA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BETA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262792 86 # CATALYTIC ACTIVITY ATP + H(2)O + Fe(3+)(Out) = ADP + phosphate + Fe(3+)(In). {ECO:0000255|HAMAP-Rule MF_01706}. # EcoGene EG12340 fbpC # FUNCTION FBPC_ECOLI Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import. Responsible for energy coupling to the transport system. {ECO 0000255|HAMAP-Rule MF_01706}. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IEA:UniProtKB-HAMAP. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0015408 ferric-transporting ATPase activity; IEA:UniProtKB-HAMAP. # GO_process GO:0055072 iron ion homeostasis; IEA:UniProtKB-KW. # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0042592 homeostatic process # Gene3D 3.40.50.300 -; 1. # IntAct P37009 6 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR008995 Mo/tungstate-bd_C_term_dom # InterPro IPR013611 Transp-assoc_OB_typ2 # InterPro IPR015853 ABC_transpr_FbpC # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00190 Iron(III) transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # MISCELLANEOUS FBPC_ECOLI In E.coli, the afu system seems to have been deleted by an insertion sequence. AfuA is totally lost, afuB is partially present and afuC is totally conserved. # Organism FBPC_ECOLI Escherichia coli (strain K12) # PATRIC 32115643 VBIEscCol129921_0265 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # PROSITE PS51242 FBPC # Pfam PF00005 ABC_tran # Pfam PF08402 TOBE_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Fe(3+) ions import ATP-binding protein FbpC {ECO:0000255|HAMAP-Rule MF_01706} # RefSeq NP_414796 NC_000913.3 # RefSeq WP_000192349 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB08683.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=L20943; Type=Frameshift; Positions=147, 220; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ABC transporter superfamily. Fe(3+) ion importer (TC 3.A.1.10) family. {ECO:0000255|HAMAP-Rule MF_01706}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|HAMAP- Rule MF_01706}. # SMART SM00382 AAA # SUBCELLULAR LOCATION FBPC_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01706}; Peripheral membrane protein {ECO 0000255|HAMAP- Rule MF_01706}. # SUBUNIT The complex is composed of two ATP-binding proteins (FbpC), two transmembrane proteins (FbpB) and a solute-binding protein (FbpA). {ECO:0000255|HAMAP-Rule MF_01706}. # SUPFAM SSF50331 SSF50331 # SUPFAM SSF52540 SSF52540 # eggNOG COG3842 LUCA # eggNOG ENOG4105C53 Bacteria BLAST swissprot:FBPC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FBPC_ECOLI BioCyc ECOL316407:JW0254-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0254-MONOMER BioCyc EcoCyc:YAGC-MONOMER http://biocyc.org/getid?id=EcoCyc:YAGC-MONOMER COG COG3841 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3841 DIP DIP-9064N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9064N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.3.30 {ECO:0000255|HAMAP-Rule:MF_01706} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.30 {ECO:0000255|HAMAP-Rule:MF_01706} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L20943 http://www.ebi.ac.uk/ena/data/view/L20943 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 ENZYME 3.6.3.30 {ECO:0000255|HAMAP-Rule:MF_01706} http://enzyme.expasy.org/EC/3.6.3.30 {ECO:0000255|HAMAP-Rule:MF_01706} EchoBASE EB2244 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2244 EcoGene EG12340 http://www.ecogene.org/geneInfo.php?eg_id=EG12340 EnsemblBacteria AAC73365 http://www.ensemblgenomes.org/id/AAC73365 EnsemblBacteria AAC73365 http://www.ensemblgenomes.org/id/AAC73365 EnsemblBacteria BAA77930 http://www.ensemblgenomes.org/id/BAA77930 EnsemblBacteria BAA77930 http://www.ensemblgenomes.org/id/BAA77930 EnsemblBacteria BAA77930 http://www.ensemblgenomes.org/id/BAA77930 EnsemblBacteria b0262 http://www.ensemblgenomes.org/id/b0262 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0015408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015408 GO_process GO:0055072 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055072 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947676 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947676 InParanoid P37009 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37009 IntAct P37009 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37009* IntEnz 3.6.3.30 {ECO:0000255|HAMAP-Rule:MF_01706} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.30 {ECO:0000255|HAMAP-Rule:MF_01706} InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR008995 http://www.ebi.ac.uk/interpro/entry/IPR008995 InterPro IPR013611 http://www.ebi.ac.uk/interpro/entry/IPR013611 InterPro IPR015853 http://www.ebi.ac.uk/interpro/entry/IPR015853 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0254 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0254 KEGG_Gene eco:b0262 http://www.genome.jp/dbget-bin/www_bget?eco:b0262 KEGG_Orthology KO:K02010 http://www.genome.jp/dbget-bin/www_bget?KO:K02010 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 MINT MINT-1316081 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1316081 OMA PDGECLV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PDGECLV PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PROSITE PS51242 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51242 PSORT swissprot:FBPC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FBPC_ECOLI PSORT-B swissprot:FBPC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FBPC_ECOLI PSORT2 swissprot:FBPC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FBPC_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Pfam PF08402 http://pfam.xfam.org/family/PF08402 Phobius swissprot:FBPC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FBPC_ECOLI PhylomeDB P37009 http://phylomedb.org/?seqid=P37009 ProteinModelPortal P37009 http://www.proteinmodelportal.org/query/uniprot/P37009 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8113168 http://www.ncbi.nlm.nih.gov/pubmed/8113168 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414796 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414796 RefSeq WP_000192349 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000192349 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P37009 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37009 STRING 511145.b0262 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0262&targetmode=cogs STRING COG3841 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3841&targetmode=cogs SUPFAM SSF50331 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50331 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB FBPC_ECOLI http://www.uniprot.org/uniprot/FBPC_ECOLI UniProtKB-AC P37009 http://www.uniprot.org/uniprot/P37009 charge swissprot:FBPC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FBPC_ECOLI eggNOG COG3842 http://eggnogapi.embl.de/nog_data/html/tree/COG3842 eggNOG ENOG4105C53 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C53 epestfind swissprot:FBPC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FBPC_ECOLI garnier swissprot:FBPC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FBPC_ECOLI helixturnhelix swissprot:FBPC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FBPC_ECOLI hmoment swissprot:FBPC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FBPC_ECOLI iep swissprot:FBPC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FBPC_ECOLI inforesidue swissprot:FBPC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FBPC_ECOLI octanol swissprot:FBPC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FBPC_ECOLI pepcoil swissprot:FBPC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FBPC_ECOLI pepdigest swissprot:FBPC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FBPC_ECOLI pepinfo swissprot:FBPC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FBPC_ECOLI pepnet swissprot:FBPC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FBPC_ECOLI pepstats swissprot:FBPC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FBPC_ECOLI pepwheel swissprot:FBPC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FBPC_ECOLI pepwindow swissprot:FBPC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FBPC_ECOLI sigcleave swissprot:FBPC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FBPC_ECOLI ## Database ID URL or Descriptions # AltName ODO1_ECOLI Alpha-ketoglutarate dehydrogenase # BRENDA 1.2.4 2026 # CATALYTIC ACTIVITY ODO1_ECOLI 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO(2). # COFACTOR Name=thiamine diphosphate; Xref=ChEBI:CHEBI 58937; # EcoGene EG10979 sucA # FUNCTION ODO1_ECOLI The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3). # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0045252 oxoglutarate dehydrogenase complex; IBA:GO_Central. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity; IDA:EcoCyc. # GO_function GO:0030976 thiamine pyrophosphate binding; IDA:EcoCyc. # GO_process GO:0006096 glycolytic process; IEA:UniProtKB-KW. # GO_process GO:0006099 tricarboxylic acid cycle; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.970 -; 2. # INTERACTION ODO1_ECOLI Self; NbExp=2; IntAct=EBI-543523, EBI-543523; P0AFG6 sucB; NbExp=5; IntAct=EBI-543523, EBI-558621; # IntAct P0AFG3 13 # InterPro IPR001017 DH_E1 # InterPro IPR005475 Transketolase-like_Pyr-bd # InterPro IPR011603 2oxoglutarate_DH_E1 # InterPro IPR029061 THDP-binding # InterPro IPR031717 KGD_C # InterPro IPR032106 2-oxogl_dehyd_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00020 Citrate cycle (TCA cycle) # KEGG_Pathway ko00310 Lysine degradation # KEGG_Pathway ko00380 Tryptophan metabolism # Organism ODO1_ECOLI Escherichia coli (strain K12) # PANTHER PTHR23152 PTHR23152 # PATRIC 32116647 VBIEscCol129921_0756 # PDB 2JGD X-ray; 2.60 A; A/B=1-933 # PIR E64808 DEECOG # PIRSF PIRSF000157 Oxoglu_dh_E1 # Pfam PF00676 E1_dh # Pfam PF02779 Transket_pyr # Pfam PF16078 2-oxogl_dehyd_N # Pfam PF16870 OxoGdeHyase_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ODO1_ECOLI 2-oxoglutarate dehydrogenase E1 component # RefSeq NP_415254 NC_000913.3 # RefSeq WP_001181473 NZ_LN832404.1 # SIMILARITY Belongs to the alpha-ketoglutarate dehydrogenase family. {ECO 0000305}. # SMART SM00861 Transket_pyr # SUBUNIT ODO1_ECOLI Homodimer. # SUPFAM SSF52518 SSF52518; 2 # TIGRFAMs TIGR00239 2oxo_dh_E1 # eggNOG COG0567 LUCA # eggNOG ENOG4105C7P Bacteria BLAST swissprot:ODO1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ODO1_ECOLI BioCyc ECOL316407:JW0715-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0715-MONOMER BioCyc EcoCyc:E1O-MONOMER http://biocyc.org/getid?id=EcoCyc:E1O-MONOMER BioCyc MetaCyc:E1O-MONOMER http://biocyc.org/getid?id=MetaCyc:E1O-MONOMER COG COG0567 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0567 DIP DIP-36225N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36225N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1432-1033.1984.tb08199.x http://dx.doi.org/10.1111/j.1432-1033.1984.tb08199.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.2.4.2 http://www.genome.jp/dbget-bin/www_bget?EC:1.2.4.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01619 http://www.ebi.ac.uk/ena/data/view/J01619 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X00661 http://www.ebi.ac.uk/ena/data/view/X00661 ENZYME 1.2.4.2 http://enzyme.expasy.org/EC/1.2.4.2 EchoBASE EB0972 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0972 EcoGene EG10979 http://www.ecogene.org/geneInfo.php?eg_id=EG10979 EnsemblBacteria AAC73820 http://www.ensemblgenomes.org/id/AAC73820 EnsemblBacteria AAC73820 http://www.ensemblgenomes.org/id/AAC73820 EnsemblBacteria BAA35392 http://www.ensemblgenomes.org/id/BAA35392 EnsemblBacteria BAA35392 http://www.ensemblgenomes.org/id/BAA35392 EnsemblBacteria BAA35392 http://www.ensemblgenomes.org/id/BAA35392 EnsemblBacteria b0726 http://www.ensemblgenomes.org/id/b0726 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0045252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045252 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0004591 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004591 GO_function GO:0030976 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030976 GO_process GO:0006096 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006096 GO_process GO:0006099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006099 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.970 http://www.cathdb.info/version/latest/superfamily/3.40.50.970 GeneID 945303 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945303 HOGENOM HOG000259587 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000259587&db=HOGENOM6 InParanoid P0AFG3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFG3 IntAct P0AFG3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFG3* IntEnz 1.2.4.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.2.4.2 InterPro IPR001017 http://www.ebi.ac.uk/interpro/entry/IPR001017 InterPro IPR005475 http://www.ebi.ac.uk/interpro/entry/IPR005475 InterPro IPR011603 http://www.ebi.ac.uk/interpro/entry/IPR011603 InterPro IPR029061 http://www.ebi.ac.uk/interpro/entry/IPR029061 InterPro IPR031717 http://www.ebi.ac.uk/interpro/entry/IPR031717 InterPro IPR032106 http://www.ebi.ac.uk/interpro/entry/IPR032106 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0715 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0715 KEGG_Gene eco:b0726 http://www.genome.jp/dbget-bin/www_bget?eco:b0726 KEGG_Orthology KO:K00164 http://www.genome.jp/dbget-bin/www_bget?KO:K00164 KEGG_Pathway ko00020 http://www.genome.jp/kegg-bin/show_pathway?ko00020 KEGG_Pathway ko00310 http://www.genome.jp/kegg-bin/show_pathway?ko00310 KEGG_Pathway ko00380 http://www.genome.jp/kegg-bin/show_pathway?ko00380 KEGG_Reaction rn:R00621 http://www.genome.jp/dbget-bin/www_bget?rn:R00621 KEGG_Reaction rn:R01933 http://www.genome.jp/dbget-bin/www_bget?rn:R01933 KEGG_Reaction rn:R01940 http://www.genome.jp/dbget-bin/www_bget?rn:R01940 KEGG_Reaction rn:R03316 http://www.genome.jp/dbget-bin/www_bget?rn:R03316 MINT MINT-1243484 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1243484 OMA QNQGAWF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QNQGAWF PANTHER PTHR23152 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23152 PDB 2JGD http://www.ebi.ac.uk/pdbe-srv/view/entry/2JGD PDBsum 2JGD http://www.ebi.ac.uk/pdbsum/2JGD PSORT swissprot:ODO1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ODO1_ECOLI PSORT-B swissprot:ODO1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ODO1_ECOLI PSORT2 swissprot:ODO1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ODO1_ECOLI Pfam PF00676 http://pfam.xfam.org/family/PF00676 Pfam PF02779 http://pfam.xfam.org/family/PF02779 Pfam PF16078 http://pfam.xfam.org/family/PF16078 Pfam PF16870 http://pfam.xfam.org/family/PF16870 Phobius swissprot:ODO1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ODO1_ECOLI ProteinModelPortal P0AFG3 http://www.proteinmodelportal.org/query/uniprot/P0AFG3 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6376123 http://www.ncbi.nlm.nih.gov/pubmed/6376123 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_415254 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415254 RefSeq WP_001181473 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001181473 SMART SM00861 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00861 SMR P0AFG3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFG3 STRING 511145.b0726 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0726&targetmode=cogs STRING COG0567 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0567&targetmode=cogs SUPFAM SSF52518 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52518 SWISS-2DPAGE P0AFG3 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AFG3 TIGRFAMs TIGR00239 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00239 UniProtKB ODO1_ECOLI http://www.uniprot.org/uniprot/ODO1_ECOLI UniProtKB-AC P0AFG3 http://www.uniprot.org/uniprot/P0AFG3 charge swissprot:ODO1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ODO1_ECOLI eggNOG COG0567 http://eggnogapi.embl.de/nog_data/html/tree/COG0567 eggNOG ENOG4105C7P http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C7P epestfind swissprot:ODO1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ODO1_ECOLI garnier swissprot:ODO1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ODO1_ECOLI helixturnhelix swissprot:ODO1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ODO1_ECOLI hmoment swissprot:ODO1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ODO1_ECOLI iep swissprot:ODO1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ODO1_ECOLI inforesidue swissprot:ODO1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ODO1_ECOLI octanol swissprot:ODO1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ODO1_ECOLI pepcoil swissprot:ODO1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ODO1_ECOLI pepdigest swissprot:ODO1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ODO1_ECOLI pepinfo swissprot:ODO1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ODO1_ECOLI pepnet swissprot:ODO1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ODO1_ECOLI pepstats swissprot:ODO1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ODO1_ECOLI pepwheel swissprot:ODO1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ODO1_ECOLI pepwindow swissprot:ODO1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ODO1_ECOLI sigcleave swissprot:ODO1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ODO1_ECOLI ## Database ID URL or Descriptions # AltName CUTA_ECOLI C-type cytochrome biogenesis protein CycY # BioGrid 4262693 8 # COFACTOR CUTA_ECOLI Name=Cu cation; Xref=ChEBI CHEBI 23378; Evidence={ECO 0000305|PubMed 12949080}; Note=Binds 1 copper ion per subunit. {ECO 0000305|PubMed 12949080}; # EcoGene EG12177 cutA # FUNCTION CUTA_ECOLI Involved in resistance toward heavy metals. {ECO 0000269|PubMed 7623666}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0005507 copper ion binding; IBA:GO_Central. # GO_function GO:0046872 metal ion binding; IDA:EcoCyc. # GO_process GO:0046688 response to copper ion; IMP:EcoCyc. # GO_process GO:0051260 protein homooligomerization; IDA:UniProtKB. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0008150 biological_process # HAMAP MF_01160 CutA # IntAct P69488 9 # InterPro IPR004323 Ion_tolerance_CutA # InterPro IPR011322 N-reg_PII-like_a/b # InterPro IPR023700 CutA_bact # Organism CUTA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR23419 PTHR23419 # PATRIC 32123841 VBIEscCol129921_4268 # PDB 1NAQ X-ray; 1.70 A; A/B/C/D/E/F=1-112 # PDB 3AA8 X-ray; 2.30 A; A/B/C=1-112 # PDB 3AA9 X-ray; 2.30 A; A/B/C=1-112 # PDB 3AH6 X-ray; 2.40 A; A/B/C/D/E/F=1-112 # PDB 3X3U X-ray; 2.09 A; A/B/C/D/E/F=1-112 # PDB 4Y65 X-ray; 1.70 A; A/B/C=1-112 # PDB 4Y6I X-ray; 1.70 A; A/B/C/D/E/F=5-112 # PIR I41027 I41027 # Pfam PF03091 CutA1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CUTA_ECOLI Divalent-cation tolerance protein CutA # RefSeq NP_418560 NC_000913.3 # RefSeq WP_000883400 NZ_LN832404.1 # SIMILARITY Belongs to the CutA family. {ECO 0000305}. # SUBCELLULAR LOCATION CUTA_ECOLI Cytoplasm {ECO 0000305|PubMed 7623666}. # SUBUNIT Homotrimer. {ECO:0000269|PubMed 12949080}. # SUPFAM SSF54913 SSF54913 # eggNOG COG1324 LUCA # eggNOG ENOG4105VF7 Bacteria BLAST swissprot:CUTA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CUTA_ECOLI BioCyc ECOL316407:JW4097-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4097-MONOMER BioCyc EcoCyc:EG12177-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12177-MONOMER COG COG1324 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1324 DIP DIP-47984N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47984N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M304398200 http://dx.doi.org/10.1074/jbc.M304398200 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1111/j.1365-2958.1995.tb02286.x http://dx.doi.org/10.1111/j.1365-2958.1995.tb02286.x DOI 10.1111/j.1365-2958.1995.tb02287.x http://dx.doi.org/10.1111/j.1365-2958.1995.tb02287.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X77707 http://www.ebi.ac.uk/ena/data/view/X77707 EMBL Z36905 http://www.ebi.ac.uk/ena/data/view/Z36905 EchoBASE EB2094 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2094 EcoGene EG12177 http://www.ecogene.org/geneInfo.php?eg_id=EG12177 EnsemblBacteria AAC77097 http://www.ensemblgenomes.org/id/AAC77097 EnsemblBacteria AAC77097 http://www.ensemblgenomes.org/id/AAC77097 EnsemblBacteria BAE78139 http://www.ensemblgenomes.org/id/BAE78139 EnsemblBacteria BAE78139 http://www.ensemblgenomes.org/id/BAE78139 EnsemblBacteria BAE78139 http://www.ensemblgenomes.org/id/BAE78139 EnsemblBacteria b4137 http://www.ensemblgenomes.org/id/b4137 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0005507 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005507 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0046688 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046688 GO_process GO:0051260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 948660 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948660 HAMAP MF_01160 http://hamap.expasy.org/unirule/MF_01160 HOGENOM HOG000222826 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000222826&db=HOGENOM6 InParanoid P69488 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P69488 IntAct P69488 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69488* InterPro IPR004323 http://www.ebi.ac.uk/interpro/entry/IPR004323 InterPro IPR011322 http://www.ebi.ac.uk/interpro/entry/IPR011322 InterPro IPR023700 http://www.ebi.ac.uk/interpro/entry/IPR023700 KEGG_Gene ecj:JW4097 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4097 KEGG_Gene eco:b4137 http://www.genome.jp/dbget-bin/www_bget?eco:b4137 KEGG_Orthology KO:K03926 http://www.genome.jp/dbget-bin/www_bget?KO:K03926 OMA PGMQSVY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PGMQSVY PANTHER PTHR23419 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23419 PDB 1NAQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1NAQ PDB 3AA8 http://www.ebi.ac.uk/pdbe-srv/view/entry/3AA8 PDB 3AA9 http://www.ebi.ac.uk/pdbe-srv/view/entry/3AA9 PDB 3AH6 http://www.ebi.ac.uk/pdbe-srv/view/entry/3AH6 PDB 3X3U http://www.ebi.ac.uk/pdbe-srv/view/entry/3X3U PDB 4Y65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4Y65 PDB 4Y6I http://www.ebi.ac.uk/pdbe-srv/view/entry/4Y6I PDBsum 1NAQ http://www.ebi.ac.uk/pdbsum/1NAQ PDBsum 3AA8 http://www.ebi.ac.uk/pdbsum/3AA8 PDBsum 3AA9 http://www.ebi.ac.uk/pdbsum/3AA9 PDBsum 3AH6 http://www.ebi.ac.uk/pdbsum/3AH6 PDBsum 3X3U http://www.ebi.ac.uk/pdbsum/3X3U PDBsum 4Y65 http://www.ebi.ac.uk/pdbsum/4Y65 PDBsum 4Y6I http://www.ebi.ac.uk/pdbsum/4Y6I PSORT swissprot:CUTA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CUTA_ECOLI PSORT-B swissprot:CUTA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CUTA_ECOLI PSORT2 swissprot:CUTA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CUTA_ECOLI Pfam PF03091 http://pfam.xfam.org/family/PF03091 Phobius swissprot:CUTA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CUTA_ECOLI PhylomeDB P69488 http://phylomedb.org/?seqid=P69488 ProteinModelPortal P69488 http://www.proteinmodelportal.org/query/uniprot/P69488 PubMed 12949080 http://www.ncbi.nlm.nih.gov/pubmed/12949080 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 7623666 http://www.ncbi.nlm.nih.gov/pubmed/7623666 PubMed 7623667 http://www.ncbi.nlm.nih.gov/pubmed/7623667 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418560 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418560 RefSeq WP_000883400 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000883400 SMR P69488 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69488 STRING 511145.b4137 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4137&targetmode=cogs STRING COG1324 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1324&targetmode=cogs SUPFAM SSF54913 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54913 UniProtKB CUTA_ECOLI http://www.uniprot.org/uniprot/CUTA_ECOLI UniProtKB-AC P69488 http://www.uniprot.org/uniprot/P69488 charge swissprot:CUTA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CUTA_ECOLI eggNOG COG1324 http://eggnogapi.embl.de/nog_data/html/tree/COG1324 eggNOG ENOG4105VF7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VF7 epestfind swissprot:CUTA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CUTA_ECOLI garnier swissprot:CUTA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CUTA_ECOLI helixturnhelix swissprot:CUTA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CUTA_ECOLI hmoment swissprot:CUTA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CUTA_ECOLI iep swissprot:CUTA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CUTA_ECOLI inforesidue swissprot:CUTA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CUTA_ECOLI octanol swissprot:CUTA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CUTA_ECOLI pepcoil swissprot:CUTA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CUTA_ECOLI pepdigest swissprot:CUTA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CUTA_ECOLI pepinfo swissprot:CUTA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CUTA_ECOLI pepnet swissprot:CUTA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CUTA_ECOLI pepstats swissprot:CUTA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CUTA_ECOLI pepwheel swissprot:CUTA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CUTA_ECOLI pepwindow swissprot:CUTA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CUTA_ECOLI sigcleave swissprot:CUTA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CUTA_ECOLI ## Database ID URL or Descriptions # EcoGene EG10762 prfB # FUNCTION RF2_ECOLI Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0016149 translation release factor activity, codon specific; IDA:EcoCyc. # GO_function GO:0043022 ribosome binding; IBA:GO_Central. # GO_process GO:0006415 translational termination; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008135 translation factor activity, RNA binding # GOslim_process GO:0008150 biological_process # Gene3D 3.30.160.20 -; 1. # HAMAP MF_00094 Rel_fac_2 # IntAct P07012 19 # InterPro IPR000352 Pep_chain_release_fac_I_II # InterPro IPR004374 PrfB # InterPro IPR005139 PCRF # InterPro IPR014720 dsRBD_dom # InterPro IPR020853 Peptide_chain_release_fac2_bac # KEGG_Brite ko03012 Translation factors # MISCELLANEOUS RF2_ECOLI The gene for this protein contains a UGA in-frame termination codon after Leu-25; a naturally occurring frameshift enables complete translation of RF-2. This provides a mechanism for the protein to regulate its own production. # Organism RF2_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11075:SF6 PTHR11075:SF6 # PATRIC 32121192 VBIEscCol129921_2984 # PDB 1GQE X-ray; 1.81 A; A=1-365 # PDB 1MI6 EM; 10.90 A; A=1-365 # PDB 1ML5 EM; 14.00 A; Z=1-365 # PDB 5CZP X-ray; 3.30 A; QY/XY=1-365 # PDB 5DFE X-ray; 3.10 A; QY/XY=1-365 # PIR C65073 FCECR2 # PROSITE PS00745 RF_PROK_I # PTM RF2_ECOLI Methylated by PrmC. Methylation increases the termination efficiency of RF2. Is absent when the factor is overproduced. {ECO 0000269|PubMed 11118225, ECO 0000269|PubMed 11805295, ECO 0000269|PubMed 11847124}. # Pfam PF00472 RF-1 # Pfam PF03462 PCRF # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RF2_ECOLI Peptide chain release factor 2 # RefSeq NP_417367 NC_000913.3 # SIMILARITY Belongs to the prokaryotic/mitochondrial release factor family. {ECO 0000305}. # SMART SM00937 PCRF # SUBCELLULAR LOCATION RF2_ECOLI Cytoplasm. # TIGRFAMs TIGR00020 prfB # eggNOG COG1186 LUCA # eggNOG ENOG4105CG1 Bacteria BLAST swissprot:RF2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RF2_ECOLI BioCyc ECOL316407:JW5847-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5847-MONOMER BioCyc EcoCyc:EG10762-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10762-MONOMER COG COG1186 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1186 DIP DIP-10559N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10559N DOI 10.1016/S1097-2765(01)00415-4 http://dx.doi.org/10.1016/S1097-2765(01)00415-4 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature01224 http://dx.doi.org/10.1038/nature01224 DOI 10.1038/nature01225 http://dx.doi.org/10.1038/nature01225 DOI 10.1073/pnas.032488499 http://dx.doi.org/10.1073/pnas.032488499 DOI 10.1073/pnas.82.11.3616 http://dx.doi.org/10.1073/pnas.82.11.3616 DOI 10.1073/pnas.85.15.5620 http://dx.doi.org/10.1073/pnas.85.15.5620 DOI 10.1074/jbc.M706076200 http://dx.doi.org/10.1074/jbc.M706076200 DOI 10.1093/emboj/19.24.6900 http://dx.doi.org/10.1093/emboj/19.24.6900 DOI 10.1093/emboj/21.4.769 http://dx.doi.org/10.1093/emboj/21.4.769 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J03795 http://www.ebi.ac.uk/ena/data/view/J03795 EMBL M11520 http://www.ebi.ac.uk/ena/data/view/M11520 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 EchoBASE EB0755 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0755 EcoGene EG10762 http://www.ecogene.org/geneInfo.php?eg_id=EG10762 EnsemblBacteria AAC75929 http://www.ensemblgenomes.org/id/AAC75929 EnsemblBacteria AAC75929 http://www.ensemblgenomes.org/id/AAC75929 EnsemblBacteria BAE76956 http://www.ensemblgenomes.org/id/BAE76956 EnsemblBacteria BAE76956 http://www.ensemblgenomes.org/id/BAE76956 EnsemblBacteria BAE76956 http://www.ensemblgenomes.org/id/BAE76956 EnsemblBacteria b2891 http://www.ensemblgenomes.org/id/b2891 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0016149 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016149 GO_function GO:0043022 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043022 GO_process GO:0006415 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006415 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008135 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008135 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.30.160.20 http://www.cathdb.info/version/latest/superfamily/3.30.160.20 GeneID 947369 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947369 HAMAP MF_00094 http://hamap.expasy.org/unirule/MF_00094 HOGENOM HOG000074814 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000074814&db=HOGENOM6 InParanoid P07012 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P07012 IntAct P07012 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P07012* InterPro IPR000352 http://www.ebi.ac.uk/interpro/entry/IPR000352 InterPro IPR004374 http://www.ebi.ac.uk/interpro/entry/IPR004374 InterPro IPR005139 http://www.ebi.ac.uk/interpro/entry/IPR005139 InterPro IPR014720 http://www.ebi.ac.uk/interpro/entry/IPR014720 InterPro IPR020853 http://www.ebi.ac.uk/interpro/entry/IPR020853 KEGG_Brite ko03012 http://www.genome.jp/dbget-bin/www_bget?ko03012 KEGG_Gene ecj:JW5847 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5847 KEGG_Gene eco:b2891 http://www.genome.jp/dbget-bin/www_bget?eco:b2891 KEGG_Orthology KO:K02836 http://www.genome.jp/dbget-bin/www_bget?KO:K02836 MINT MINT-1238444 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1238444 OMA RLYEHEM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RLYEHEM PANTHER PTHR11075:SF6 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11075:SF6 PDB 1GQE http://www.ebi.ac.uk/pdbe-srv/view/entry/1GQE PDB 1MI6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1MI6 PDB 1ML5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ML5 PDB 5CZP http://www.ebi.ac.uk/pdbe-srv/view/entry/5CZP PDB 5DFE http://www.ebi.ac.uk/pdbe-srv/view/entry/5DFE PDBsum 1GQE http://www.ebi.ac.uk/pdbsum/1GQE PDBsum 1MI6 http://www.ebi.ac.uk/pdbsum/1MI6 PDBsum 1ML5 http://www.ebi.ac.uk/pdbsum/1ML5 PDBsum 5CZP http://www.ebi.ac.uk/pdbsum/5CZP PDBsum 5DFE http://www.ebi.ac.uk/pdbsum/5DFE PROSITE PS00745 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00745 PSORT swissprot:RF2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RF2_ECOLI PSORT-B swissprot:RF2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RF2_ECOLI PSORT2 swissprot:RF2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RF2_ECOLI Pfam PF00472 http://pfam.xfam.org/family/PF00472 Pfam PF03462 http://pfam.xfam.org/family/PF03462 Phobius swissprot:RF2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RF2_ECOLI PhylomeDB P07012 http://phylomedb.org/?seqid=P07012 ProteinModelPortal P07012 http://www.proteinmodelportal.org/query/uniprot/P07012 PubMed 11118225 http://www.ncbi.nlm.nih.gov/pubmed/11118225 PubMed 11779511 http://www.ncbi.nlm.nih.gov/pubmed/11779511 PubMed 11805295 http://www.ncbi.nlm.nih.gov/pubmed/11805295 PubMed 11847124 http://www.ncbi.nlm.nih.gov/pubmed/11847124 PubMed 12511960 http://www.ncbi.nlm.nih.gov/pubmed/12511960 PubMed 12511961 http://www.ncbi.nlm.nih.gov/pubmed/12511961 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17932046 http://www.ncbi.nlm.nih.gov/pubmed/17932046 PubMed 2456575 http://www.ncbi.nlm.nih.gov/pubmed/2456575 PubMed 3049538 http://www.ncbi.nlm.nih.gov/pubmed/3049538 PubMed 3889910 http://www.ncbi.nlm.nih.gov/pubmed/3889910 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417367 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417367 SMART SM00937 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00937 SMR P07012 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P07012 STRING 511145.b2891 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2891&targetmode=cogs STRING COG1186 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1186&targetmode=cogs TIGRFAMs TIGR00020 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00020 UniProtKB RF2_ECOLI http://www.uniprot.org/uniprot/RF2_ECOLI UniProtKB-AC P07012 http://www.uniprot.org/uniprot/P07012 charge swissprot:RF2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RF2_ECOLI eggNOG COG1186 http://eggnogapi.embl.de/nog_data/html/tree/COG1186 eggNOG ENOG4105CG1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CG1 epestfind swissprot:RF2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RF2_ECOLI garnier swissprot:RF2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RF2_ECOLI helixturnhelix swissprot:RF2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RF2_ECOLI hmoment swissprot:RF2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RF2_ECOLI iep swissprot:RF2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RF2_ECOLI inforesidue swissprot:RF2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RF2_ECOLI octanol swissprot:RF2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RF2_ECOLI pepcoil swissprot:RF2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RF2_ECOLI pepdigest swissprot:RF2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RF2_ECOLI pepinfo swissprot:RF2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RF2_ECOLI pepnet swissprot:RF2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RF2_ECOLI pepstats swissprot:RF2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RF2_ECOLI pepwheel swissprot:RF2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RF2_ECOLI pepwindow swissprot:RF2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RF2_ECOLI sigcleave swissprot:RF2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RF2_ECOLI ## Database ID URL or Descriptions # BioGrid 4260341 111 # CATALYTIC ACTIVITY YOAA_ECOLI ATP + H(2)O = ADP + phosphate. # EcoGene EG13513 yoaA # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0008026 ATP-dependent helicase activity; IEA:InterPro. # GO_process GO:0006139 nucleobase-containing compound metabolic process; IEA:InterPro. # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004386 helicase activity # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.50.300 -; 3. # IntAct P76257 9 # InterPro IPR006555 ATP-dep_Helicase_C # InterPro IPR006935 Helicase/UvrB_N # InterPro IPR014001 Helicase_ATP-bd # InterPro IPR014013 Helic_SF1/SF2_ATP-bd_DinG/Rad3 # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko01000 Enzymes # Organism YOAA_ECOLI Escherichia coli (strain K12) # PATRIC 32118933 VBIEscCol129921_1884 # PIR H64941 H64941 # PROSITE PS51193 HELICASE_ATP_BIND_2 # Pfam PF04851 ResIII # Pfam PF13307 Helicase_C_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YOAA_ECOLI Probable ATP-dependent helicase YoaA # RefSeq NP_416322 NC_000913.3 # RefSeq WP_000128841 NZ_LN832404.1 # SIMILARITY Belongs to the helicase family. DinG subfamily. {ECO 0000305}. # SIMILARITY Contains 1 helicase ATP-binding domain. {ECO:0000255|PROSITE-ProRule PRU00541}. # SMART SM00487 DEXDc # SMART SM00491 HELICc2 # SUPFAM SSF52540 SSF52540; 4 # eggNOG COG1199 LUCA # eggNOG ENOG4105DVT Bacteria BLAST swissprot:YOAA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YOAA_ECOLI BioCyc ECOL316407:JW1797-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1797-MONOMER BioCyc EcoCyc:G6992-MONOMER http://biocyc.org/getid?id=EcoCyc:G6992-MONOMER DIP DIP-12786N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12786N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.4.12 http://www.genome.jp/dbget-bin/www_bget?EC:3.6.4.12 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.6.4.12 http://enzyme.expasy.org/EC/3.6.4.12 EchoBASE EB3286 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3286 EcoGene EG13513 http://www.ecogene.org/geneInfo.php?eg_id=EG13513 EnsemblBacteria AAC74878 http://www.ensemblgenomes.org/id/AAC74878 EnsemblBacteria AAC74878 http://www.ensemblgenomes.org/id/AAC74878 EnsemblBacteria BAA15617 http://www.ensemblgenomes.org/id/BAA15617 EnsemblBacteria BAA15617 http://www.ensemblgenomes.org/id/BAA15617 EnsemblBacteria BAA15617 http://www.ensemblgenomes.org/id/BAA15617 EnsemblBacteria b1808 http://www.ensemblgenomes.org/id/b1808 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008026 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008026 GO_process GO:0006139 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006139 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004386 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 946305 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946305 HOGENOM HOG000242574 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000242574&db=HOGENOM6 InParanoid P76257 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76257 IntAct P76257 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76257* IntEnz 3.6.4.12 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.4.12 InterPro IPR006555 http://www.ebi.ac.uk/interpro/entry/IPR006555 InterPro IPR006935 http://www.ebi.ac.uk/interpro/entry/IPR006935 InterPro IPR014001 http://www.ebi.ac.uk/interpro/entry/IPR014001 InterPro IPR014013 http://www.ebi.ac.uk/interpro/entry/IPR014013 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1797 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1797 KEGG_Gene eco:b1808 http://www.genome.jp/dbget-bin/www_bget?eco:b1808 KEGG_Orthology KO:K01529 http://www.genome.jp/dbget-bin/www_bget?KO:K01529 OMA AKIIVVN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AKIIVVN PROSITE PS51193 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51193 PSORT swissprot:YOAA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YOAA_ECOLI PSORT-B swissprot:YOAA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YOAA_ECOLI PSORT2 swissprot:YOAA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YOAA_ECOLI Pfam PF04851 http://pfam.xfam.org/family/PF04851 Pfam PF13307 http://pfam.xfam.org/family/PF13307 Phobius swissprot:YOAA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YOAA_ECOLI PhylomeDB P76257 http://phylomedb.org/?seqid=P76257 ProteinModelPortal P76257 http://www.proteinmodelportal.org/query/uniprot/P76257 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416322 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416322 RefSeq WP_000128841 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000128841 SMART SM00487 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00487 SMART SM00491 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00491 SMR P76257 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76257 STRING 511145.b1808 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1808&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB YOAA_ECOLI http://www.uniprot.org/uniprot/YOAA_ECOLI UniProtKB-AC P76257 http://www.uniprot.org/uniprot/P76257 charge swissprot:YOAA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YOAA_ECOLI eggNOG COG1199 http://eggnogapi.embl.de/nog_data/html/tree/COG1199 eggNOG ENOG4105DVT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DVT epestfind swissprot:YOAA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YOAA_ECOLI garnier swissprot:YOAA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YOAA_ECOLI helixturnhelix swissprot:YOAA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YOAA_ECOLI hmoment swissprot:YOAA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YOAA_ECOLI iep swissprot:YOAA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YOAA_ECOLI inforesidue swissprot:YOAA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YOAA_ECOLI octanol swissprot:YOAA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YOAA_ECOLI pepcoil swissprot:YOAA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YOAA_ECOLI pepdigest swissprot:YOAA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YOAA_ECOLI pepinfo swissprot:YOAA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YOAA_ECOLI pepnet swissprot:YOAA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YOAA_ECOLI pepstats swissprot:YOAA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YOAA_ECOLI pepwheel swissprot:YOAA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YOAA_ECOLI pepwindow swissprot:YOAA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YOAA_ECOLI sigcleave swissprot:YOAA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YOAA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262090 136 # EcoGene EG11094 sbcD # FUNCTION SBCD_ECOLI SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity. # GO_function GO:0004519 endonuclease activity; IEA:UniProtKB-KW. # GO_function GO:0008408 3'-5' exonuclease activity; IEA:InterPro. # GO_process GO:0006259 DNA metabolic process; IDA:EcoCyc. # GO_process GO:0006260 DNA replication; IEA:UniProtKB-KW. # GO_process GO:0006310 DNA recombination; IEA:UniProtKB-KW. # GOslim_function GO:0004518 nuclease activity # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.60.21.10 -; 1. # IntAct P0AG76 5 # InterPro IPR004593 SbcD # InterPro IPR004843 Calcineurin-like_PHP_ApaH # InterPro IPR026843 SbcD_C # InterPro IPR029052 Metallo-depent_PP-like # KEGG_Brite ko03400 DNA repair and recombination proteins # Organism SBCD_ECOLI Escherichia coli (strain K12) # PATRIC 32115939 VBIEscCol129921_0411 # PIR JS0349 JS0349 # Pfam PF00149 Metallophos # Pfam PF12320 SbcD_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SBCD_ECOLI Nuclease SbcCD subunit D # RefSeq NP_414932 NC_000913.3 # RefSeq WP_001221319 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18122.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the SbcD family. {ECO 0000305}. # SUBUNIT SBCD_ECOLI Heterodimer of SbcC and SbcD. # SUPFAM SSF56300 SSF56300 # TIGRFAMs TIGR00619 sbcd # eggNOG COG0420 LUCA # eggNOG ENOG4107RH8 Bacteria BLAST swissprot:SBCD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SBCD_ECOLI BioCyc ECOL316407:JW0388-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0388-MONOMER BioCyc EcoCyc:EG11094-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11094-MONOMER BioCyc MetaCyc:EG11094-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11094-MONOMER COG COG0420 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0420 DIP DIP-10828N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10828N DOI 10.1007/BF00120998 http://dx.doi.org/10.1007/BF00120998 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.95.14.7969 http://dx.doi.org/10.1073/pnas.95.14.7969 DOI 10.1093/nar/17.20.8033 http://dx.doi.org/10.1093/nar/17.20.8033 DOI 10.1093/nar/27.4.1039 http://dx.doi.org/10.1093/nar/27.4.1039 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EMBL X15981 http://www.ebi.ac.uk/ena/data/view/X15981 EchoBASE EB1086 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1086 EcoGene EG11094 http://www.ecogene.org/geneInfo.php?eg_id=EG11094 EnsemblBacteria AAC73501 http://www.ensemblgenomes.org/id/AAC73501 EnsemblBacteria AAC73501 http://www.ensemblgenomes.org/id/AAC73501 EnsemblBacteria BAE76178 http://www.ensemblgenomes.org/id/BAE76178 EnsemblBacteria BAE76178 http://www.ensemblgenomes.org/id/BAE76178 EnsemblBacteria BAE76178 http://www.ensemblgenomes.org/id/BAE76178 EnsemblBacteria b0398 http://www.ensemblgenomes.org/id/b0398 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004519 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004519 GO_function GO:0008408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008408 GO_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GO_process GO:0006260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.60.21.10 http://www.cathdb.info/version/latest/superfamily/3.60.21.10 GeneID 945049 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945049 HOGENOM HOG000026261 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000026261&db=HOGENOM6 InParanoid P0AG76 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AG76 IntAct P0AG76 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AG76* InterPro IPR004593 http://www.ebi.ac.uk/interpro/entry/IPR004593 InterPro IPR004843 http://www.ebi.ac.uk/interpro/entry/IPR004843 InterPro IPR026843 http://www.ebi.ac.uk/interpro/entry/IPR026843 InterPro IPR029052 http://www.ebi.ac.uk/interpro/entry/IPR029052 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW0388 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0388 KEGG_Gene eco:b0398 http://www.genome.jp/dbget-bin/www_bget?eco:b0398 KEGG_Orthology KO:K03547 http://www.genome.jp/dbget-bin/www_bget?KO:K03547 OMA SVREIYV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SVREIYV PSORT swissprot:SBCD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SBCD_ECOLI PSORT-B swissprot:SBCD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SBCD_ECOLI PSORT2 swissprot:SBCD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SBCD_ECOLI Pfam PF00149 http://pfam.xfam.org/family/PF00149 Pfam PF12320 http://pfam.xfam.org/family/PF12320 Phobius swissprot:SBCD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SBCD_ECOLI PhylomeDB P0AG76 http://phylomedb.org/?seqid=P0AG76 ProteinModelPortal P0AG76 http://www.proteinmodelportal.org/query/uniprot/P0AG76 PubMed 1490631 http://www.ncbi.nlm.nih.gov/pubmed/1490631 PubMed 1531222 http://www.ncbi.nlm.nih.gov/pubmed/1531222 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2530497 http://www.ncbi.nlm.nih.gov/pubmed/2530497 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9653124 http://www.ncbi.nlm.nih.gov/pubmed/9653124 PubMed 9927737 http://www.ncbi.nlm.nih.gov/pubmed/9927737 RefSeq NP_414932 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414932 RefSeq WP_001221319 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001221319 SMR P0AG76 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AG76 STRING 511145.b0398 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0398&targetmode=cogs STRING COG0420 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0420&targetmode=cogs SUPFAM SSF56300 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56300 TIGRFAMs TIGR00619 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00619 UniProtKB SBCD_ECOLI http://www.uniprot.org/uniprot/SBCD_ECOLI UniProtKB-AC P0AG76 http://www.uniprot.org/uniprot/P0AG76 charge swissprot:SBCD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SBCD_ECOLI eggNOG COG0420 http://eggnogapi.embl.de/nog_data/html/tree/COG0420 eggNOG ENOG4107RH8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107RH8 epestfind swissprot:SBCD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SBCD_ECOLI garnier swissprot:SBCD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SBCD_ECOLI helixturnhelix swissprot:SBCD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SBCD_ECOLI hmoment swissprot:SBCD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SBCD_ECOLI iep swissprot:SBCD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SBCD_ECOLI inforesidue swissprot:SBCD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SBCD_ECOLI octanol swissprot:SBCD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SBCD_ECOLI pepcoil swissprot:SBCD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SBCD_ECOLI pepdigest swissprot:SBCD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SBCD_ECOLI pepinfo swissprot:SBCD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SBCD_ECOLI pepnet swissprot:SBCD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SBCD_ECOLI pepstats swissprot:SBCD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SBCD_ECOLI pepwheel swissprot:SBCD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SBCD_ECOLI pepwindow swissprot:SBCD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SBCD_ECOLI sigcleave swissprot:SBCD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SBCD_ECOLI ## Database ID URL or Descriptions # BioGrid 4260624 9 # EcoGene EG13198 yfjL # GO_process GO:0051607 defense response to virus; IMP:EcoCyc. # GOslim_process GO:0002376 immune system process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0044403 symbiosis, encompassing mutualism through parasitism # IntAct P52127 3 # InterPro IPR014976 DUF1837 # InterPro IPR025382 DUF4297 # Organism YFJL_ECOLI Escherichia coli (strain K12) # PATRIC 32120649 VBIEscCol129921_2723 # PIR T08640 T08640 # Pfam PF08878 DUF1837 # Pfam PF14130 DUF4297 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFJL_ECOLI Uncharacterized protein YfjL # RefSeq NP_417117 NC_000913.3 # RefSeq WP_000445380 NZ_LN832404.1 # eggNOG ENOG4105JPW Bacteria # eggNOG ENOG4111R47 LUCA BLAST swissprot:YFJL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFJL_ECOLI BioCyc ECOL316407:JW2609-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2609-MONOMER BioCyc EcoCyc:G7363-MONOMER http://biocyc.org/getid?id=EcoCyc:G7363-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36840 http://www.ebi.ac.uk/ena/data/view/U36840 EchoBASE EB2990 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2990 EcoGene EG13198 http://www.ecogene.org/geneInfo.php?eg_id=EG13198 EnsemblBacteria AAC75676 http://www.ensemblgenomes.org/id/AAC75676 EnsemblBacteria AAC75676 http://www.ensemblgenomes.org/id/AAC75676 EnsemblBacteria BAE76763 http://www.ensemblgenomes.org/id/BAE76763 EnsemblBacteria BAE76763 http://www.ensemblgenomes.org/id/BAE76763 EnsemblBacteria BAE76763 http://www.ensemblgenomes.org/id/BAE76763 EnsemblBacteria b2628 http://www.ensemblgenomes.org/id/b2628 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0051607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051607 GOslim_process GO:0002376 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0044403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403 GeneID 947110 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947110 HOGENOM HOG000054866 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000054866&db=HOGENOM6 IntAct P52127 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P52127* InterPro IPR014976 http://www.ebi.ac.uk/interpro/entry/IPR014976 InterPro IPR025382 http://www.ebi.ac.uk/interpro/entry/IPR025382 KEGG_Gene ecj:JW2609 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2609 KEGG_Gene eco:b2628 http://www.genome.jp/dbget-bin/www_bget?eco:b2628 OMA VECETAD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VECETAD PSORT swissprot:YFJL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFJL_ECOLI PSORT-B swissprot:YFJL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFJL_ECOLI PSORT2 swissprot:YFJL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFJL_ECOLI Pfam PF08878 http://pfam.xfam.org/family/PF08878 Pfam PF14130 http://pfam.xfam.org/family/PF14130 Phobius swissprot:YFJL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFJL_ECOLI ProteinModelPortal P52127 http://www.proteinmodelportal.org/query/uniprot/P52127 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417117 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417117 RefSeq WP_000445380 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000445380 STRING 511145.b2628 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2628&targetmode=cogs UniProtKB YFJL_ECOLI http://www.uniprot.org/uniprot/YFJL_ECOLI UniProtKB-AC P52127 http://www.uniprot.org/uniprot/P52127 charge swissprot:YFJL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFJL_ECOLI eggNOG ENOG4105JPW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105JPW eggNOG ENOG4111R47 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111R47 epestfind swissprot:YFJL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFJL_ECOLI garnier swissprot:YFJL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFJL_ECOLI helixturnhelix swissprot:YFJL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFJL_ECOLI hmoment swissprot:YFJL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFJL_ECOLI iep swissprot:YFJL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFJL_ECOLI inforesidue swissprot:YFJL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFJL_ECOLI octanol swissprot:YFJL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFJL_ECOLI pepcoil swissprot:YFJL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFJL_ECOLI pepdigest swissprot:YFJL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFJL_ECOLI pepinfo swissprot:YFJL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFJL_ECOLI pepnet swissprot:YFJL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFJL_ECOLI pepstats swissprot:YFJL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFJL_ECOLI pepwheel swissprot:YFJL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFJL_ECOLI pepwindow swissprot:YFJL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFJL_ECOLI sigcleave swissprot:YFJL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFJL_ECOLI ## Database ID URL or Descriptions # AltName RECT_ECOLI P33 # BioGrid 4260162 60 # EcoGene EG11899 recT # FUNCTION RECT_ECOLI Binds to single-stranded DNA and also promotes the renaturation of complementary single-stranded DNA. Function in recombination. Has a function similar to that of lambda RedB. # GO_component GO:0032993 protein-DNA complex; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0003697 single-stranded DNA binding; IDA:EcoCyc. # GO_process GO:0032508 DNA duplex unwinding; IDA:EcoCyc. # GO_process GO:0043150 DNA synthesis involved in double-strand break repair via homologous recombination; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0051276 chromosome organization # IntAct P33228 9 # InterPro IPR004590 ssDNA_annealing_RecT # InterPro IPR018330 RecT_fam # KEGG_Brite ko03400 DNA repair and recombination proteins # Organism RECT_ECOLI Escherichia coli (strain K12) # PATRIC 32117976 VBIEscCol129921_1408 # PIR I69516 I69516 # Pfam PF03837 RecT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RECT_ECOLI Protein RecT # RefSeq NP_415865 NC_000913.3 # RefSeq WP_000166319 NZ_CP014272.1 # SUBUNIT RECT_ECOLI Homotetramer. # TIGRFAMs TIGR00616 rect # eggNOG COG3723 LUCA # eggNOG ENOG4108PNI Bacteria BLAST swissprot:RECT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RECT_ECOLI BioCyc ECOL316407:JW1343-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1343-MONOMER BioCyc EcoCyc:EG11899-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11899-MONOMER COG COG3723 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3723 DIP DIP-10657N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10657N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L23927 http://www.ebi.ac.uk/ena/data/view/L23927 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1844 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1844 EcoGene EG11899 http://www.ecogene.org/geneInfo.php?eg_id=EG11899 EnsemblBacteria AAC74431 http://www.ensemblgenomes.org/id/AAC74431 EnsemblBacteria AAC74431 http://www.ensemblgenomes.org/id/AAC74431 EnsemblBacteria BAA14949 http://www.ensemblgenomes.org/id/BAA14949 EnsemblBacteria BAA14949 http://www.ensemblgenomes.org/id/BAA14949 EnsemblBacteria BAA14949 http://www.ensemblgenomes.org/id/BAA14949 EnsemblBacteria b1349 http://www.ensemblgenomes.org/id/b1349 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0032993 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032993 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003697 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003697 GO_process GO:0032508 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032508 GO_process GO:0043150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043150 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0051276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051276 GeneID 945917 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945917 HOGENOM HOG000068465 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000068465&db=HOGENOM6 InParanoid P33228 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33228 IntAct P33228 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33228* InterPro IPR004590 http://www.ebi.ac.uk/interpro/entry/IPR004590 InterPro IPR018330 http://www.ebi.ac.uk/interpro/entry/IPR018330 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW1343 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1343 KEGG_Gene eco:b1349 http://www.genome.jp/dbget-bin/www_bget?eco:b1349 KEGG_Orthology KO:K07455 http://www.genome.jp/dbget-bin/www_bget?KO:K07455 OMA HRIANSK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HRIANSK PSORT swissprot:RECT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RECT_ECOLI PSORT-B swissprot:RECT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RECT_ECOLI PSORT2 swissprot:RECT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RECT_ECOLI Pfam PF03837 http://pfam.xfam.org/family/PF03837 Phobius swissprot:RECT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RECT_ECOLI PhylomeDB P33228 http://phylomedb.org/?seqid=P33228 ProteinModelPortal P33228 http://www.proteinmodelportal.org/query/uniprot/P33228 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8244937 http://www.ncbi.nlm.nih.gov/pubmed/8244937 PubMed 8416902 http://www.ncbi.nlm.nih.gov/pubmed/8416902 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415865 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415865 RefSeq WP_000166319 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000166319 STRING 511145.b1349 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1349&targetmode=cogs STRING COG3723 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3723&targetmode=cogs TIGRFAMs TIGR00616 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00616 UniProtKB RECT_ECOLI http://www.uniprot.org/uniprot/RECT_ECOLI UniProtKB-AC P33228 http://www.uniprot.org/uniprot/P33228 charge swissprot:RECT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RECT_ECOLI eggNOG COG3723 http://eggnogapi.embl.de/nog_data/html/tree/COG3723 eggNOG ENOG4108PNI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108PNI epestfind swissprot:RECT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RECT_ECOLI garnier swissprot:RECT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RECT_ECOLI helixturnhelix swissprot:RECT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RECT_ECOLI hmoment swissprot:RECT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RECT_ECOLI iep swissprot:RECT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RECT_ECOLI inforesidue swissprot:RECT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RECT_ECOLI octanol swissprot:RECT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RECT_ECOLI pepcoil swissprot:RECT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RECT_ECOLI pepdigest swissprot:RECT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RECT_ECOLI pepinfo swissprot:RECT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RECT_ECOLI pepnet swissprot:RECT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RECT_ECOLI pepstats swissprot:RECT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RECT_ECOLI pepwheel swissprot:RECT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RECT_ECOLI pepwindow swissprot:RECT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RECT_ECOLI sigcleave swissprot:RECT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RECT_ECOLI ## Database ID URL or Descriptions # AltName PFKB_ECOLI 6-phosphofructokinase isozyme II # AltName PFKB_ECOLI Phosphohexokinase 2 # BIOPHYSICOCHEMICAL PROPERTIES PFKB_ECOLI Kinetic parameters KM=8 uM for ATP {ECO 0000269|PubMed 23823238}; KM=6 uM for fructose 6-phosphate {ECO 0000269|PubMed 23823238}; # BRENDA 2.7.1.11 2026 # BioGrid 4263076 14 # CATALYTIC ACTIVITY PFKB_ECOLI ATP + D-fructose 6-phosphate = ADP + D- fructose 1,6-bisphosphate. {ECO 0000269|PubMed 16866375, ECO 0000269|PubMed 23823238}. # CDD cd01164 FruK_PfkB_like # COFACTOR PFKB_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 16866375}; # ENZYME REGULATION PFKB_ECOLI Allosterically inhibited by ATP. Allosteric ATP-binding requires the presence of the substrate ATP. Inhibited by monovalent cations with ionic radii larger than Na(+) (e.g. K(+), Cs(+)). The monovalent cations increase the affinity of the allosteric site for ATP. PFK-2 is sensitive to inhibition by fructose 1,6-diphosphate. {ECO 0000269|PubMed 16866375, ECO 0000269|PubMed 23823238}. # EcoGene EG10700 pfkB # FUNCTION PFKB_ECOLI Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. {ECO 0000269|PubMed 16866375}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0003872 6-phosphofructokinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0009024 tagatose-6-phosphate kinase activity; IDA:EcoCyc. # GO_process GO:0006096 glycolytic process; IMP:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.1190.20 -; 1. # INTERACTION PFKB_ECOLI Self; NbExp=2; IntAct=EBI-6966085, EBI-6966085; # InterPro IPR002173 Carboh/pur_kinase_PfkB_CS # InterPro IPR011611 PfkB_dom # InterPro IPR017583 Tagatose/fructose_Pkinase # InterPro IPR029056 Ribokinase-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00010 Glycolysis / Gluconeogenesis # KEGG_Pathway ko00030 Pentose phosphate pathway # KEGG_Pathway ko00051 Fructose and mannose metabolism # KEGG_Pathway ko00052 Galactose metabolism # KEGG_Pathway ko00680 Methane metabolism # MISCELLANEOUS PFKB_ECOLI E.coli has two 6-phosphofructokinases enzymes. # MISCELLANEOUS PFKB_ECOLI Only 10% of the activity present in the wild-type strain is phosphofructokinase-2. # MISCELLANEOUS PFKB_ECOLI This enzyme is not to be confused with 6- phosphofructo-2-kinase which is also called phosphofructokinase 2. # Organism PFKB_ECOLI Escherichia coli (strain K12) # PATHWAY Carbohydrate degradation; glycolysis; D-glyceraldehyde 3- phosphate and glycerone phosphate from D-glucose step 3/4. # PATRIC 32118753 VBIEscCol129921_1794 # PDB 3CQD X-ray; 1.98 A; A/B=1-309 # PDB 3N1C X-ray; 2.00 A; A/B/C/D=1-309 # PDB 3UMO X-ray; 1.70 A; A/B=1-309 # PDB 3UMP X-ray; 1.85 A; A/B=1-309 # PDB 3UQD X-ray; 2.14 A; A/B/C/D=1-309 # PDB 3UQE X-ray; 2.20 A; A/B=1-309 # PIR C64931 KIECFB # PIRSF PIRSF000535 1PFK/6PFK/LacC # PROSITE PS00583 PFKB_KINASES_1 # PROSITE PS00584 PFKB_KINASES_2 # Pfam PF00294 PfkB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PFKB_ECOLI ATP-dependent 6-phosphofructokinase isozyme 2 # RefSeq NP_416237 NC_000913.3 # RefSeq WP_000251727 NZ_LN832404.1 # SIMILARITY Belongs to the carbohydrate kinase PfkB family. {ECO 0000305}. # SUBUNIT PFKB_ECOLI Homodimer. {ECO 0000269|PubMed 18762190, ECO 0000269|PubMed 21147773, ECO 0000269|PubMed 23823238, ECO 0000269|Ref.10, ECO 0000269|Ref.11}. # SUPFAM SSF53613 SSF53613 # TIGRFAMs TIGR03168 1-PFK # UniPathway UPA00109 UER00182 # eggNOG COG1105 LUCA # eggNOG ENOG4105DE4 Bacteria BLAST swissprot:PFKB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PFKB_ECOLI BioCyc ECOL316407:JW5280-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5280-MONOMER BioCyc EcoCyc:6PFK-2-MONOMER http://biocyc.org/getid?id=EcoCyc:6PFK-2-MONOMER BioCyc MetaCyc:6PFK-2-MONOMER http://biocyc.org/getid?id=MetaCyc:6PFK-2-MONOMER COG COG1105 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1105 DIP DIP-10465N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10465N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0378-1119(84)90151-3 http://dx.doi.org/10.1016/0378-1119(84)90151-3 DOI 10.1016/S0022-2836(83)80019-9 http://dx.doi.org/10.1016/S0022-2836(83)80019-9 DOI 10.1016/j.bpj.2013.05.028 http://dx.doi.org/10.1016/j.bpj.2013.05.028 DOI 10.1016/j.jmb.2008.08.029 http://dx.doi.org/10.1016/j.jmb.2008.08.029 DOI 10.1021/bi060026o http://dx.doi.org/10.1021/bi060026o DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M110.163162 http://dx.doi.org/10.1074/jbc.M110.163162 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.11 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.11 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K00128 http://www.ebi.ac.uk/ena/data/view/K00128 EMBL K02500 http://www.ebi.ac.uk/ena/data/view/K02500 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.11 http://enzyme.expasy.org/EC/2.7.1.11 EchoBASE EB0694 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0694 EcoGene EG10700 http://www.ecogene.org/geneInfo.php?eg_id=EG10700 EnsemblBacteria AAC74793 http://www.ensemblgenomes.org/id/AAC74793 EnsemblBacteria AAC74793 http://www.ensemblgenomes.org/id/AAC74793 EnsemblBacteria BAA15500 http://www.ensemblgenomes.org/id/BAA15500 EnsemblBacteria BAA15500 http://www.ensemblgenomes.org/id/BAA15500 EnsemblBacteria BAA15500 http://www.ensemblgenomes.org/id/BAA15500 EnsemblBacteria b1723 http://www.ensemblgenomes.org/id/b1723 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0003872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003872 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0009024 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009024 GO_process GO:0006096 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006096 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.1190.20 http://www.cathdb.info/version/latest/superfamily/3.40.1190.20 GeneID 946230 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946230 HOGENOM HOG000265281 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000265281&db=HOGENOM6 InParanoid P06999 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P06999 IntEnz 2.7.1.11 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.11 InterPro IPR002173 http://www.ebi.ac.uk/interpro/entry/IPR002173 InterPro IPR011611 http://www.ebi.ac.uk/interpro/entry/IPR011611 InterPro IPR017583 http://www.ebi.ac.uk/interpro/entry/IPR017583 InterPro IPR029056 http://www.ebi.ac.uk/interpro/entry/IPR029056 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5280 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5280 KEGG_Gene eco:b1723 http://www.genome.jp/dbget-bin/www_bget?eco:b1723 KEGG_Orthology KO:K16370 http://www.genome.jp/dbget-bin/www_bget?KO:K16370 KEGG_Pathway ko00010 http://www.genome.jp/kegg-bin/show_pathway?ko00010 KEGG_Pathway ko00030 http://www.genome.jp/kegg-bin/show_pathway?ko00030 KEGG_Pathway ko00051 http://www.genome.jp/kegg-bin/show_pathway?ko00051 KEGG_Pathway ko00052 http://www.genome.jp/kegg-bin/show_pathway?ko00052 KEGG_Pathway ko00680 http://www.genome.jp/kegg-bin/show_pathway?ko00680 KEGG_Reaction rn:R03236 http://www.genome.jp/dbget-bin/www_bget?rn:R03236 KEGG_Reaction rn:R03237 http://www.genome.jp/dbget-bin/www_bget?rn:R03237 KEGG_Reaction rn:R03238 http://www.genome.jp/dbget-bin/www_bget?rn:R03238 KEGG_Reaction rn:R03239 http://www.genome.jp/dbget-bin/www_bget?rn:R03239 KEGG_Reaction rn:R04779 http://www.genome.jp/dbget-bin/www_bget?rn:R04779 MINT MINT-8178151 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8178151 OMA REYRFLM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=REYRFLM PDB 3CQD http://www.ebi.ac.uk/pdbe-srv/view/entry/3CQD PDB 3N1C http://www.ebi.ac.uk/pdbe-srv/view/entry/3N1C PDB 3UMO http://www.ebi.ac.uk/pdbe-srv/view/entry/3UMO PDB 3UMP http://www.ebi.ac.uk/pdbe-srv/view/entry/3UMP PDB 3UQD http://www.ebi.ac.uk/pdbe-srv/view/entry/3UQD PDB 3UQE http://www.ebi.ac.uk/pdbe-srv/view/entry/3UQE PDBsum 3CQD http://www.ebi.ac.uk/pdbsum/3CQD PDBsum 3N1C http://www.ebi.ac.uk/pdbsum/3N1C PDBsum 3UMO http://www.ebi.ac.uk/pdbsum/3UMO PDBsum 3UMP http://www.ebi.ac.uk/pdbsum/3UMP PDBsum 3UQD http://www.ebi.ac.uk/pdbsum/3UQD PDBsum 3UQE http://www.ebi.ac.uk/pdbsum/3UQE PROSITE PS00583 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00583 PROSITE PS00584 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00584 PSORT swissprot:PFKB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PFKB_ECOLI PSORT-B swissprot:PFKB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PFKB_ECOLI PSORT2 swissprot:PFKB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PFKB_ECOLI Pfam PF00294 http://pfam.xfam.org/family/PF00294 Phobius swissprot:PFKB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PFKB_ECOLI PhylomeDB P06999 http://phylomedb.org/?seqid=P06999 ProteinModelPortal P06999 http://www.proteinmodelportal.org/query/uniprot/P06999 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16866375 http://www.ncbi.nlm.nih.gov/pubmed/16866375 PubMed 18762190 http://www.ncbi.nlm.nih.gov/pubmed/18762190 PubMed 21147773 http://www.ncbi.nlm.nih.gov/pubmed/21147773 PubMed 23823238 http://www.ncbi.nlm.nih.gov/pubmed/23823238 PubMed 6235149 http://www.ncbi.nlm.nih.gov/pubmed/6235149 PubMed 6310120 http://www.ncbi.nlm.nih.gov/pubmed/6310120 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_416237 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416237 RefSeq WP_000251727 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000251727 SMR P06999 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P06999 STRING 511145.b1723 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1723&targetmode=cogs STRING COG1105 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1105&targetmode=cogs SUPFAM SSF53613 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53613 SWISS-2DPAGE P06999 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P06999 TIGRFAMs TIGR03168 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03168 UniProtKB PFKB_ECOLI http://www.uniprot.org/uniprot/PFKB_ECOLI UniProtKB-AC P06999 http://www.uniprot.org/uniprot/P06999 charge swissprot:PFKB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PFKB_ECOLI eggNOG COG1105 http://eggnogapi.embl.de/nog_data/html/tree/COG1105 eggNOG ENOG4105DE4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DE4 epestfind swissprot:PFKB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PFKB_ECOLI garnier swissprot:PFKB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PFKB_ECOLI helixturnhelix swissprot:PFKB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PFKB_ECOLI hmoment swissprot:PFKB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PFKB_ECOLI iep swissprot:PFKB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PFKB_ECOLI inforesidue swissprot:PFKB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PFKB_ECOLI octanol swissprot:PFKB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PFKB_ECOLI pepcoil swissprot:PFKB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PFKB_ECOLI pepdigest swissprot:PFKB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PFKB_ECOLI pepinfo swissprot:PFKB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PFKB_ECOLI pepnet swissprot:PFKB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PFKB_ECOLI pepstats swissprot:PFKB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PFKB_ECOLI pepwheel swissprot:PFKB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PFKB_ECOLI pepwindow swissprot:PFKB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PFKB_ECOLI sigcleave swissprot:PFKB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PFKB_ECOLI ## Database ID URL or Descriptions # CAUTION Could be the product of a pseudogene. The sequence shown here is interrupted by an IS5Y insertion sequence. {ECO 0000305}. # EcoGene EG14315 lomR # GO_component GO:0009279 cell outer membrane; IEA:InterPro. # GO_component GO:0016021 integral component of membrane; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # Gene3D 2.40.160.20 -; 2. # InterPro IPR000758 Enterovir_OMP # InterPro IPR011250 OMP/PagP_b-brl # MISCELLANEOUS LOMR_ECOLI This protein is encoded on Rac prophage. # Organism LOMR_ECOLI Escherichia coli (strain K12) # PIR T09188 T09188 # PRINTS PR00316 ENTEROVIROMP # PROSITE PS00695 ENT_VIR_OMP_2 # Pfam PF06316 Ail_Lom; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LOMR_ECOLI Putative protein LomR # SIMILARITY Belongs to the Ail/OmpX/PagC/Lom family. {ECO 0000305}. # SUPFAM SSF56925 SSF56925; 2 BLAST swissprot:LOMR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LOMR_ECOLI DIP DIP-48047N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48047N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14315 http://www.ecogene.org/geneInfo.php?eg_id=EG14315 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 Gene3D 2.40.160.20 http://www.cathdb.info/version/latest/superfamily/2.40.160.20 InterPro IPR000758 http://www.ebi.ac.uk/interpro/entry/IPR000758 InterPro IPR011250 http://www.ebi.ac.uk/interpro/entry/IPR011250 PRINTS PR00316 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00316 PROSITE PS00695 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00695 PSORT swissprot:LOMR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LOMR_ECOLI PSORT-B swissprot:LOMR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LOMR_ECOLI PSORT2 swissprot:LOMR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LOMR_ECOLI Pfam PF06316 http://pfam.xfam.org/family/PF06316 Phobius swissprot:LOMR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LOMR_ECOLI ProteinModelPortal P77184 http://www.proteinmodelportal.org/query/uniprot/P77184 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SMR P77184 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77184 SUPFAM SSF56925 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56925 UniProtKB LOMR_ECOLI http://www.uniprot.org/uniprot/LOMR_ECOLI UniProtKB-AC P77184 http://www.uniprot.org/uniprot/P77184 charge swissprot:LOMR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LOMR_ECOLI epestfind swissprot:LOMR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LOMR_ECOLI garnier swissprot:LOMR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LOMR_ECOLI helixturnhelix swissprot:LOMR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LOMR_ECOLI hmoment swissprot:LOMR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LOMR_ECOLI iep swissprot:LOMR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LOMR_ECOLI inforesidue swissprot:LOMR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LOMR_ECOLI octanol swissprot:LOMR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LOMR_ECOLI pepcoil swissprot:LOMR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LOMR_ECOLI pepdigest swissprot:LOMR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LOMR_ECOLI pepinfo swissprot:LOMR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LOMR_ECOLI pepnet swissprot:LOMR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LOMR_ECOLI pepstats swissprot:LOMR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LOMR_ECOLI pepwheel swissprot:LOMR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LOMR_ECOLI pepwindow swissprot:LOMR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LOMR_ECOLI sigcleave swissprot:LOMR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LOMR_ECOLI ## Database ID URL or Descriptions # AltName TRMJ_ECOLI tRNA (cytidine(32)/uridine(32)-2'-O)-methyltransferase # AltName TRMJ_ECOLI tRNA Cm32/Um32 methyltransferase # BRENDA 2.1.1.200 2026 # BioGrid 4263050 2 # CATALYTIC ACTIVITY TRMJ_ECOLI S-adenosyl-L-methionine + cytidine(32) in tRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine(32) in tRNA. # CATALYTIC ACTIVITY TRMJ_ECOLI S-adenosyl-L-methionine + uridine(32) in tRNA = S-adenosyl-L-homocysteine + 2'-O-methyluridine(32) in tRNA. # EcoGene EG13452 trmJ # FUNCTION TRMJ_ECOLI Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. {ECO 0000269|PubMed 16848900}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003723 RNA binding; IBA:GO_Central. # GO_function GO:0052665 tRNA (uracil-2'-O-)-methyltransferase activity; IMP:EcoCyc. # GO_function GO:0052666 tRNA (cytosine-2'-O-)-methyltransferase activity; IMP:EcoCyc. # GO_process GO:0002128 tRNA nucleoside ribose methylation; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0006399 tRNA metabolic process # Gene3D 3.40.1280.10 -; 1. # IntAct P0AE01 3 # InterPro IPR001537 SpoU_MeTrfase # InterPro IPR004384 rRNA_MeTrfase_TrmH_1 # InterPro IPR029026 tRNA_m1G_MTases_N # InterPro IPR029028 Alpha/beta_knot_MTases # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # Organism TRMJ_ECOLI Escherichia coli (strain K12) # PATRIC 32120461 VBIEscCol129921_2633 # PDB 4CND X-ray; 1.50 A; A/B=1-246 # PDB 4CNE X-ray; 1.90 A; A/B=1-246 # PDB 4XBO X-ray; 2.60 A; A/B=1-246 # PIR C65030 C65030 # PIRSF PIRSF004808 LasT # Pfam PF00588 SpoU_methylase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TRMJ_ECOLI tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ # RefSeq NP_417027 NC_000913.3 # RefSeq WP_000940019 NZ_LN832404.1 # SIMILARITY Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. {ECO 0000305}. # SUBCELLULAR LOCATION TRMJ_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 16848900}. # SUPFAM SSF75217 SSF75217 # TIGRFAMs TIGR00050 rRNA_methyl_1 # eggNOG COG0565 LUCA # eggNOG ENOG4105CVS Bacteria BLAST swissprot:TRMJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRMJ_ECOLI BioCyc ECOL316407:JW2516-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2516-MONOMER BioCyc EcoCyc:G7327-MONOMER http://biocyc.org/getid?id=EcoCyc:G7327-MONOMER BioCyc MetaCyc:G7327-MONOMER http://biocyc.org/getid?id=MetaCyc:G7327-MONOMER COG COG0565 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0565 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1186/1471-2199-7-23 http://dx.doi.org/10.1186/1471-2199-7-23 EC_number EC:2.1.1.200 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.200 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.1.1.200 http://enzyme.expasy.org/EC/2.1.1.200 EchoBASE EB3225 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3225 EcoGene EG13452 http://www.ecogene.org/geneInfo.php?eg_id=EG13452 EnsemblBacteria AAC75585 http://www.ensemblgenomes.org/id/AAC75585 EnsemblBacteria AAC75585 http://www.ensemblgenomes.org/id/AAC75585 EnsemblBacteria BAA16426 http://www.ensemblgenomes.org/id/BAA16426 EnsemblBacteria BAA16426 http://www.ensemblgenomes.org/id/BAA16426 EnsemblBacteria BAA16426 http://www.ensemblgenomes.org/id/BAA16426 EnsemblBacteria b2532 http://www.ensemblgenomes.org/id/b2532 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0052665 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052665 GO_function GO:0052666 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052666 GO_process GO:0002128 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002128 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 Gene3D 3.40.1280.10 http://www.cathdb.info/version/latest/superfamily/3.40.1280.10 GeneID 948610 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948610 HOGENOM HOG000229628 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000229628&db=HOGENOM6 InParanoid P0AE01 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AE01 IntAct P0AE01 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AE01* IntEnz 2.1.1.200 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.200 InterPro IPR001537 http://www.ebi.ac.uk/interpro/entry/IPR001537 InterPro IPR004384 http://www.ebi.ac.uk/interpro/entry/IPR004384 InterPro IPR029026 http://www.ebi.ac.uk/interpro/entry/IPR029026 InterPro IPR029028 http://www.ebi.ac.uk/interpro/entry/IPR029028 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW2516 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2516 KEGG_Gene eco:b2532 http://www.genome.jp/dbget-bin/www_bget?eco:b2532 KEGG_Orthology KO:K15396 http://www.genome.jp/dbget-bin/www_bget?KO:K15396 OMA ELQRCHF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ELQRCHF PDB 4CND http://www.ebi.ac.uk/pdbe-srv/view/entry/4CND PDB 4CNE http://www.ebi.ac.uk/pdbe-srv/view/entry/4CNE PDB 4XBO http://www.ebi.ac.uk/pdbe-srv/view/entry/4XBO PDBsum 4CND http://www.ebi.ac.uk/pdbsum/4CND PDBsum 4CNE http://www.ebi.ac.uk/pdbsum/4CNE PDBsum 4XBO http://www.ebi.ac.uk/pdbsum/4XBO PSORT swissprot:TRMJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRMJ_ECOLI PSORT-B swissprot:TRMJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRMJ_ECOLI PSORT2 swissprot:TRMJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRMJ_ECOLI Pfam PF00588 http://pfam.xfam.org/family/PF00588 Phobius swissprot:TRMJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRMJ_ECOLI PhylomeDB P0AE01 http://phylomedb.org/?seqid=P0AE01 ProteinModelPortal P0AE01 http://www.proteinmodelportal.org/query/uniprot/P0AE01 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16848900 http://www.ncbi.nlm.nih.gov/pubmed/16848900 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417027 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417027 RefSeq WP_000940019 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000940019 SMR P0AE01 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AE01 STRING 511145.b2532 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2532&targetmode=cogs STRING COG0565 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0565&targetmode=cogs SUPFAM SSF75217 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF75217 TIGRFAMs TIGR00050 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00050 UniProtKB TRMJ_ECOLI http://www.uniprot.org/uniprot/TRMJ_ECOLI UniProtKB-AC P0AE01 http://www.uniprot.org/uniprot/P0AE01 charge swissprot:TRMJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRMJ_ECOLI eggNOG COG0565 http://eggnogapi.embl.de/nog_data/html/tree/COG0565 eggNOG ENOG4105CVS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CVS epestfind swissprot:TRMJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRMJ_ECOLI garnier swissprot:TRMJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRMJ_ECOLI helixturnhelix swissprot:TRMJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRMJ_ECOLI hmoment swissprot:TRMJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRMJ_ECOLI iep swissprot:TRMJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRMJ_ECOLI inforesidue swissprot:TRMJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRMJ_ECOLI octanol swissprot:TRMJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRMJ_ECOLI pepcoil swissprot:TRMJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRMJ_ECOLI pepdigest swissprot:TRMJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRMJ_ECOLI pepinfo swissprot:TRMJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRMJ_ECOLI pepnet swissprot:TRMJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRMJ_ECOLI pepstats swissprot:TRMJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRMJ_ECOLI pepwheel swissprot:TRMJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRMJ_ECOLI pepwindow swissprot:TRMJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRMJ_ECOLI sigcleave swissprot:TRMJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRMJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4262794 7 # CAUTION Could be the product of a pseudogene. An insertion element (ISX') seems to have deleted the end of yagB, fusing it to 13 insX' codons to make a 116 fusion pseudogene that may be expressed. The cognate toxin appears to have been deleted. {ECO 0000305}. # EcoGene EG12339 yagB # IntAct P37008 4 # InterPro IPR009320 YagB_YeeU_YfjZ # Organism YAGB_ECOLI Escherichia coli (strain K12) # PATRIC 48659733 VBIEscCol107702_0262 # PIR B64752 B64752 # Pfam PF06154 CbeA_antitoxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAGB_ECOLI Putative uncharacterized protein YagB # RefSeq WP_001030800 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB08687.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=L20943; Type=Frameshift; Positions=33; Evidence={ECO 0000305}; # SIMILARITY Belongs to the CbeA/YafW/YfjZ antitoxin family. {ECO 0000305}. BLAST swissprot:YAGB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAGB_ECOLI BioCyc ECOL316407:JW0259-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0259-MONOMER BioCyc EcoCyc:EG12339-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12339-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L20943 http://www.ebi.ac.uk/ena/data/view/L20943 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EchoBASE EB2243 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2243 EcoGene EG12339 http://www.ecogene.org/geneInfo.php?eg_id=EG12339 EnsemblBacteria BAE76052 http://www.ensemblgenomes.org/id/BAE76052 EnsemblBacteria BAE76052 http://www.ensemblgenomes.org/id/BAE76052 EnsemblBacteria BAE76052 http://www.ensemblgenomes.org/id/BAE76052 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv HOGENOM HOG000290944 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000290944&db=HOGENOM6 IntAct P37008 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37008* InterPro IPR009320 http://www.ebi.ac.uk/interpro/entry/IPR009320 KEGG_Gene ecj:JW0259 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0259 OMA KSDITPR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KSDITPR PSORT swissprot:YAGB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAGB_ECOLI PSORT-B swissprot:YAGB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAGB_ECOLI PSORT2 swissprot:YAGB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAGB_ECOLI Pfam PF06154 http://pfam.xfam.org/family/PF06154 Phobius swissprot:YAGB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAGB_ECOLI PhylomeDB P37008 http://phylomedb.org/?seqid=P37008 ProteinModelPortal P37008 http://www.proteinmodelportal.org/query/uniprot/P37008 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8113168 http://www.ncbi.nlm.nih.gov/pubmed/8113168 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001030800 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001030800 SMR P37008 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37008 STRING 316407.85674410 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85674410&targetmode=cogs UniProtKB YAGB_ECOLI http://www.uniprot.org/uniprot/YAGB_ECOLI UniProtKB-AC P37008 http://www.uniprot.org/uniprot/P37008 charge swissprot:YAGB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAGB_ECOLI epestfind swissprot:YAGB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAGB_ECOLI garnier swissprot:YAGB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAGB_ECOLI helixturnhelix swissprot:YAGB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAGB_ECOLI hmoment swissprot:YAGB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAGB_ECOLI iep swissprot:YAGB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAGB_ECOLI inforesidue swissprot:YAGB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAGB_ECOLI octanol swissprot:YAGB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAGB_ECOLI pepcoil swissprot:YAGB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAGB_ECOLI pepdigest swissprot:YAGB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAGB_ECOLI pepinfo swissprot:YAGB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAGB_ECOLI pepnet swissprot:YAGB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAGB_ECOLI pepstats swissprot:YAGB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAGB_ECOLI pepwheel swissprot:YAGB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAGB_ECOLI pepwindow swissprot:YAGB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAGB_ECOLI sigcleave swissprot:YAGB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAGB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260128 348 # EcoGene EG12304 sapD # FUNCTION SAPD_ECOLI Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_function GO:0005524 ATP binding; IMP:EcoCyc. # GO_function GO:0016887 ATPase activity; IEA:InterPro. # GO_process GO:0015031 protein transport; IEA:UniProtKB-KW. # GO_process GO:0015833 peptide transport; IEA:UniProtKB-KW. # GO_process GO:0071805 potassium ion transmembrane transport; IMP:EcoCyc. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # Gene3D 3.40.50.300 -; 1. # IntAct P0AAH4 5 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR013563 Oligopep_ABC_C # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00324 Dipeptide transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism SAPD_ECOLI Escherichia coli (strain K12) # PATRIC 32117852 VBIEscCol129921_1346 # PIR F64877 F64877 # PROSITE PS50893 ABC_TRANSPORTER_2 # Pfam PF00005 ABC_tran # Pfam PF08352 oligo_HPY # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SAPD_ECOLI Peptide transport system ATP-binding protein SapD # RefSeq NP_415807 NC_000913.3 # RefSeq WP_001128858 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA # SUBCELLULAR LOCATION SAPD_ECOLI Cell inner membrane {ECO 0000305}; Peripheral membrane protein {ECO 0000305}. # SUPFAM SSF52540 SSF52540 # TCDB 3.A.1.5.42 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR01727 oligo_HPY # eggNOG COG4170 LUCA # eggNOG ENOG4108JQ3 Bacteria BLAST swissprot:SAPD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SAPD_ECOLI BioCyc ECOL316407:JW1284-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1284-MONOMER BioCyc EcoCyc:SAPD-MONOMER http://biocyc.org/getid?id=EcoCyc:SAPD-MONOMER COG COG0444 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0444 DIP DIP-10825N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10825N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U08190 http://www.ebi.ac.uk/ena/data/view/U08190 EMBL X97282 http://www.ebi.ac.uk/ena/data/view/X97282 EchoBASE EB2210 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2210 EcoGene EG12304 http://www.ecogene.org/geneInfo.php?eg_id=EG12304 EnsemblBacteria AAC74373 http://www.ensemblgenomes.org/id/AAC74373 EnsemblBacteria AAC74373 http://www.ensemblgenomes.org/id/AAC74373 EnsemblBacteria BAA14844 http://www.ensemblgenomes.org/id/BAA14844 EnsemblBacteria BAA14844 http://www.ensemblgenomes.org/id/BAA14844 EnsemblBacteria BAA14844 http://www.ensemblgenomes.org/id/BAA14844 EnsemblBacteria b1291 http://www.ensemblgenomes.org/id/b1291 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_process GO:0015031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031 GO_process GO:0015833 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015833 GO_process GO:0071805 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071805 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 946203 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946203 InParanoid P0AAH4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAH4 IntAct P0AAH4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAH4* InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR013563 http://www.ebi.ac.uk/interpro/entry/IPR013563 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1284 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1284 KEGG_Gene eco:b1291 http://www.genome.jp/dbget-bin/www_bget?eco:b1291 KEGG_Orthology KO:K12371 http://www.genome.jp/dbget-bin/www_bget?KO:K12371 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 MINT MINT-1271696 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1271696 OMA YCGQMVE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YCGQMVE PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:SAPD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SAPD_ECOLI PSORT-B swissprot:SAPD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SAPD_ECOLI PSORT2 swissprot:SAPD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SAPD_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Pfam PF08352 http://pfam.xfam.org/family/PF08352 Phobius swissprot:SAPD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SAPD_ECOLI PhylomeDB P0AAH4 http://phylomedb.org/?seqid=P0AAH4 ProteinModelPortal P0AAH4 http://www.proteinmodelportal.org/query/uniprot/P0AAH4 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415807 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415807 RefSeq WP_001128858 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001128858 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 STRING 511145.b1291 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1291&targetmode=cogs STRING COG0444 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0444&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.5.42 http://www.tcdb.org/search/result.php?tc=3.A.1.5.42 TIGRFAMs TIGR01727 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01727 UniProtKB SAPD_ECOLI http://www.uniprot.org/uniprot/SAPD_ECOLI UniProtKB-AC P0AAH4 http://www.uniprot.org/uniprot/P0AAH4 charge swissprot:SAPD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SAPD_ECOLI eggNOG COG4170 http://eggnogapi.embl.de/nog_data/html/tree/COG4170 eggNOG ENOG4108JQ3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108JQ3 epestfind swissprot:SAPD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SAPD_ECOLI garnier swissprot:SAPD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SAPD_ECOLI helixturnhelix swissprot:SAPD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SAPD_ECOLI hmoment swissprot:SAPD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SAPD_ECOLI iep swissprot:SAPD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SAPD_ECOLI inforesidue swissprot:SAPD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SAPD_ECOLI octanol swissprot:SAPD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SAPD_ECOLI pepcoil swissprot:SAPD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SAPD_ECOLI pepdigest swissprot:SAPD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SAPD_ECOLI pepinfo swissprot:SAPD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SAPD_ECOLI pepnet swissprot:SAPD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SAPD_ECOLI pepstats swissprot:SAPD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SAPD_ECOLI pepwheel swissprot:SAPD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SAPD_ECOLI pepwindow swissprot:SAPD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SAPD_ECOLI sigcleave swissprot:SAPD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SAPD_ECOLI ## Database ID URL or Descriptions # BioGrid 4262942 9 # EcoGene EG10393 glpC # FUNCTION GLPC_ECOLI Electron transfer protein; may also function as the membrane anchor for the GlpAB dimer. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IDA:EcoCyc. # GO_function GO:0051536 iron-sulfur cluster binding; IDA:EcoCyc. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0006810 transport; IEA:InterPro. # GO_process GO:0009061 anaerobic respiration; IEP:EcoCyc. # GO_process GO:0019563 glycerol catabolic process; IEA:UniProtKB-UniPathway. # GO_process GO:0022900 electron transport chain; IDA:EcoCyc. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0006810 transport # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # IntAct P0A996 20 # InterPro IPR004017 Cys_rich_dom # InterPro IPR009051 Helical_ferredxn # InterPro IPR017753 G3P_DH_GlpC_su # InterPro IPR017896 4Fe4S_Fe-S-bd # InterPro IPR017900 4Fe4S_Fe_S_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00564 Glycerophospholipid metabolism # Organism GLPC_ECOLI Escherichia coli (strain K12) # PATHWAY Polyol metabolism; glycerol degradation via glycerol kinase pathway; glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route) step 1/1. # PATRIC 32119845 VBIEscCol129921_2332 # PIR A64995 DEECNC # PROSITE PS00198 4FE4S_FER_1; 2 # PROSITE PS51379 4FE4S_FER_2; 2 # Pfam PF02754 CCG; 2 # Pfam PF13183 Fer4_8 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLPC_ECOLI Anaerobic glycerol-3-phosphate dehydrogenase subunit C # RefSeq NP_416746 NC_000913.3 # RefSeq WP_001000379 NZ_LN832404.1 # SIMILARITY Contains 2 4Fe-4S ferredoxin-type domains. {ECO:0000255|PROSITE-ProRule PRU00711}. # SUBCELLULAR LOCATION GLPC_ECOLI Cell inner membrane; Peripheral membrane protein. Note=Loosely bound to the cytoplasmic membrane often occurring in vesicles associated with fumarate reductase. # SUBUNIT GLPC_ECOLI Composed of a catalytic GlpA/B dimer and of GlpC. # SUPFAM SSF46548 SSF46548 # TIGRFAMs TIGR03379 glycerol3P_GlpC # UniPathway UPA00618 UER00673 # eggNOG COG0247 LUCA # eggNOG ENOG4105CHG Bacteria BLAST swissprot:GLPC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLPC_ECOLI BioCyc ECOL316407:JW2237-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2237-MONOMER BioCyc EcoCyc:ANGLYC3PDEHYDROGSUBUNITC-MONOMER http://biocyc.org/getid?id=EcoCyc:ANGLYC3PDEHYDROGSUBUNITC-MONOMER BioCyc MetaCyc:ANGLYC3PDEHYDROGSUBUNITC-MONOMER http://biocyc.org/getid?id=MetaCyc:ANGLYC3PDEHYDROGSUBUNITC-MONOMER COG COG0247 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0247 DIP DIP-35835N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35835N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M20938 http://www.ebi.ac.uk/ena/data/view/M20938 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0388 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0388 EcoGene EG10393 http://www.ecogene.org/geneInfo.php?eg_id=EG10393 EnsemblBacteria AAC75303 http://www.ensemblgenomes.org/id/AAC75303 EnsemblBacteria AAC75303 http://www.ensemblgenomes.org/id/AAC75303 EnsemblBacteria BAA16062 http://www.ensemblgenomes.org/id/BAA16062 EnsemblBacteria BAA16062 http://www.ensemblgenomes.org/id/BAA16062 EnsemblBacteria BAA16062 http://www.ensemblgenomes.org/id/BAA16062 EnsemblBacteria b2243 http://www.ensemblgenomes.org/id/b2243 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051536 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051536 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GO_process GO:0009061 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009061 GO_process GO:0019563 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019563 GO_process GO:0022900 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022900 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 946735 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946735 HOGENOM HOG000278500 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278500&db=HOGENOM6 InParanoid P0A996 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A996 IntAct P0A996 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A996* InterPro IPR004017 http://www.ebi.ac.uk/interpro/entry/IPR004017 InterPro IPR009051 http://www.ebi.ac.uk/interpro/entry/IPR009051 InterPro IPR017753 http://www.ebi.ac.uk/interpro/entry/IPR017753 InterPro IPR017896 http://www.ebi.ac.uk/interpro/entry/IPR017896 InterPro IPR017900 http://www.ebi.ac.uk/interpro/entry/IPR017900 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2237 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2237 KEGG_Gene eco:b2243 http://www.genome.jp/dbget-bin/www_bget?eco:b2243 KEGG_Orthology KO:K00113 http://www.genome.jp/dbget-bin/www_bget?KO:K00113 KEGG_Pathway ko00564 http://www.genome.jp/kegg-bin/show_pathway?ko00564 KEGG_Reaction rn:R00848 http://www.genome.jp/dbget-bin/www_bget?rn:R00848 OMA KEMPDNC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KEMPDNC PROSITE PS00198 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00198 PROSITE PS51379 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51379 PSORT swissprot:GLPC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLPC_ECOLI PSORT-B swissprot:GLPC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLPC_ECOLI PSORT2 swissprot:GLPC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLPC_ECOLI Pfam PF02754 http://pfam.xfam.org/family/PF02754 Pfam PF13183 http://pfam.xfam.org/family/PF13183 Phobius swissprot:GLPC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLPC_ECOLI PhylomeDB P0A996 http://phylomedb.org/?seqid=P0A996 ProteinModelPortal P0A996 http://www.proteinmodelportal.org/query/uniprot/P0A996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3286606 http://www.ncbi.nlm.nih.gov/pubmed/3286606 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416746 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416746 RefSeq WP_001000379 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001000379 SMR P0A996 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A996 STRING 511145.b2243 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2243&targetmode=cogs STRING COG0247 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0247&targetmode=cogs SUPFAM SSF46548 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46548 TIGRFAMs TIGR03379 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03379 UniProtKB GLPC_ECOLI http://www.uniprot.org/uniprot/GLPC_ECOLI UniProtKB-AC P0A996 http://www.uniprot.org/uniprot/P0A996 charge swissprot:GLPC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLPC_ECOLI eggNOG COG0247 http://eggnogapi.embl.de/nog_data/html/tree/COG0247 eggNOG ENOG4105CHG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CHG epestfind swissprot:GLPC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLPC_ECOLI garnier swissprot:GLPC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLPC_ECOLI helixturnhelix swissprot:GLPC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLPC_ECOLI hmoment swissprot:GLPC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLPC_ECOLI iep swissprot:GLPC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLPC_ECOLI inforesidue swissprot:GLPC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLPC_ECOLI octanol swissprot:GLPC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLPC_ECOLI pepcoil swissprot:GLPC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLPC_ECOLI pepdigest swissprot:GLPC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLPC_ECOLI pepinfo swissprot:GLPC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLPC_ECOLI pepnet swissprot:GLPC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLPC_ECOLI pepstats swissprot:GLPC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLPC_ECOLI pepwheel swissprot:GLPC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLPC_ECOLI pepwindow swissprot:GLPC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLPC_ECOLI sigcleave swissprot:GLPC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLPC_ECOLI ## Database ID URL or Descriptions # EcoGene EG14430 yjhX # HAMAP MF_00827 UPF0386 # InterPro IPR018654 YjhX_toxin # Organism YJHX_ECOLI Escherichia coli (strain K12) # PATRIC 32124204 VBIEscCol129921_4445 # Pfam PF09857 YjhX_toxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UPF0386 protein YjhX {ECO:0000255|HAMAP-Rule MF_00827} # RefSeq WP_001054376 NZ_LN832404.1 # RefSeq YP_588477 NC_000913.3 # SIMILARITY Belongs to the UPF0386 family. {ECO:0000255|HAMAP- Rule MF_00827}. # eggNOG COG3811 LUCA # eggNOG ENOG4105YCT Bacteria BLAST swissprot:YJHX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJHX_ECOLI BioCyc ECOL316407:JW5968-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5968-MONOMER BioCyc EcoCyc:MONOMER0-2695 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2695 COG COG3811 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3811 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14430 http://www.ecogene.org/geneInfo.php?eg_id=EG14430 EnsemblBacteria ABD18718 http://www.ensemblgenomes.org/id/ABD18718 EnsemblBacteria ABD18718 http://www.ensemblgenomes.org/id/ABD18718 EnsemblBacteria BAE78300 http://www.ensemblgenomes.org/id/BAE78300 EnsemblBacteria BAE78300 http://www.ensemblgenomes.org/id/BAE78300 EnsemblBacteria BAE78300 http://www.ensemblgenomes.org/id/BAE78300 EnsemblBacteria b4566 http://www.ensemblgenomes.org/id/b4566 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1450297 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1450297 HAMAP MF_00827 http://hamap.expasy.org/unirule/MF_00827 HOGENOM HOG000247637 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000247637&db=HOGENOM6 InParanoid Q2EEU2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q2EEU2 InterPro IPR018654 http://www.ebi.ac.uk/interpro/entry/IPR018654 KEGG_Gene ecj:JW5968 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5968 KEGG_Gene eco:b4566 http://www.genome.jp/dbget-bin/www_bget?eco:b4566 KEGG_Orthology KO:K09982 http://www.genome.jp/dbget-bin/www_bget?KO:K09982 OMA TRDGWLY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TRDGWLY PSORT swissprot:YJHX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJHX_ECOLI PSORT-B swissprot:YJHX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJHX_ECOLI PSORT2 swissprot:YJHX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJHX_ECOLI Pfam PF09857 http://pfam.xfam.org/family/PF09857 Phobius swissprot:YJHX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJHX_ECOLI ProteinModelPortal Q2EEU2 http://www.proteinmodelportal.org/query/uniprot/Q2EEU2 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001054376 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001054376 RefSeq YP_588477 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_588477 STRING 511145.b4566 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4566&targetmode=cogs STRING COG3811 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3811&targetmode=cogs UniProtKB YJHX_ECOLI http://www.uniprot.org/uniprot/YJHX_ECOLI UniProtKB-AC Q2EEU2 http://www.uniprot.org/uniprot/Q2EEU2 charge swissprot:YJHX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJHX_ECOLI eggNOG COG3811 http://eggnogapi.embl.de/nog_data/html/tree/COG3811 eggNOG ENOG4105YCT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105YCT epestfind swissprot:YJHX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJHX_ECOLI garnier swissprot:YJHX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJHX_ECOLI helixturnhelix swissprot:YJHX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJHX_ECOLI hmoment swissprot:YJHX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJHX_ECOLI iep swissprot:YJHX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJHX_ECOLI inforesidue swissprot:YJHX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJHX_ECOLI octanol swissprot:YJHX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJHX_ECOLI pepcoil swissprot:YJHX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJHX_ECOLI pepdigest swissprot:YJHX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJHX_ECOLI pepinfo swissprot:YJHX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJHX_ECOLI pepnet swissprot:YJHX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJHX_ECOLI pepstats swissprot:YJHX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJHX_ECOLI pepwheel swissprot:YJHX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJHX_ECOLI pepwindow swissprot:YJHX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJHX_ECOLI sigcleave swissprot:YJHX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJHX_ECOLI ## Database ID URL or Descriptions # BioGrid 4261223 5 # EcoGene EG14086 rhmR # GO_function GO:0003677 DNA binding; IBA:GO_Central. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IBA:GO_Central. # GO_process GO:0006351 transcription, DNA-templated; ISS:EcoCyc. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IBA:GO_Central. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # Gene3D 3.30.450.40 -; 1. # INTERACTION RHMR_ECOLI P23862 priC; NbExp=3; IntAct=EBI-549004, EBI-1117383; # IntAct P77732 4 # InterPro IPR005471 Tscrpt_reg_IclR_N # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR014757 Tscrpt_reg_IclR_C # InterPro IPR029016 GAF_dom-like # MISCELLANEOUS RHMR_ECOLI Part of the rhmRDTA operon involved in L-rhamnonate utilization. # Organism RHMR_ECOLI Escherichia coli (strain K12) # PATRIC 32119859 VBIEscCol129921_2339 # PIR F64995 F64995 # PROSITE PS51077 HTH_ICLR # PROSITE PS51078 ICLR_ED # Pfam PF01614 IclR # Pfam PF09339 HTH_IclR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RHMR_ECOLI Uncharacterized HTH-type transcriptional regulator RhmR # RefSeq NP_416751 NC_000913.3 # RefSeq WP_000894185 NZ_LN832404.1 # SIMILARITY Contains 1 HTH iclR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00393}. # SIMILARITY Contains 1 iclR-ED (iclR effector binding) domain. {ECO:0000255|PROSITE-ProRule PRU00394}. # SMART SM00346 HTH_ICLR # SUPFAM SSF46785 SSF46785 # SUPFAM SSF55781 SSF55781 # eggNOG COG1414 LUCA # eggNOG ENOG4107258 Bacteria BLAST swissprot:RHMR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RHMR_ECOLI BioCyc ECOL316407:JW2242-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2242-MONOMER BioCyc EcoCyc:G7161-MONOMER http://biocyc.org/getid?id=EcoCyc:G7161-MONOMER DIP DIP-11956N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11956N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3839 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3839 EcoGene EG14086 http://www.ecogene.org/geneInfo.php?eg_id=EG14086 EnsemblBacteria AAC75308 http://www.ensemblgenomes.org/id/AAC75308 EnsemblBacteria AAC75308 http://www.ensemblgenomes.org/id/AAC75308 EnsemblBacteria BAA16072 http://www.ensemblgenomes.org/id/BAA16072 EnsemblBacteria BAA16072 http://www.ensemblgenomes.org/id/BAA16072 EnsemblBacteria BAA16072 http://www.ensemblgenomes.org/id/BAA16072 EnsemblBacteria b2248 http://www.ensemblgenomes.org/id/b2248 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 3.30.450.40 http://www.cathdb.info/version/latest/superfamily/3.30.450.40 GeneID 944752 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944752 HOGENOM HOG000107041 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000107041&db=HOGENOM6 InParanoid P77732 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77732 IntAct P77732 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77732* InterPro IPR005471 http://www.ebi.ac.uk/interpro/entry/IPR005471 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR014757 http://www.ebi.ac.uk/interpro/entry/IPR014757 InterPro IPR029016 http://www.ebi.ac.uk/interpro/entry/IPR029016 KEGG_Gene ecj:JW2242 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2242 KEGG_Gene eco:b2248 http://www.genome.jp/dbget-bin/www_bget?eco:b2248 OMA VWERATP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VWERATP PROSITE PS51077 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51077 PROSITE PS51078 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51078 PSORT swissprot:RHMR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RHMR_ECOLI PSORT-B swissprot:RHMR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RHMR_ECOLI PSORT2 swissprot:RHMR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RHMR_ECOLI Pfam PF01614 http://pfam.xfam.org/family/PF01614 Pfam PF09339 http://pfam.xfam.org/family/PF09339 Phobius swissprot:RHMR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RHMR_ECOLI PhylomeDB P77732 http://phylomedb.org/?seqid=P77732 ProteinModelPortal P77732 http://www.proteinmodelportal.org/query/uniprot/P77732 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416751 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416751 RefSeq WP_000894185 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000894185 SMART SM00346 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00346 SMR P77732 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77732 STRING 511145.b2248 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2248&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SUPFAM SSF55781 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55781 UniProtKB RHMR_ECOLI http://www.uniprot.org/uniprot/RHMR_ECOLI UniProtKB-AC P77732 http://www.uniprot.org/uniprot/P77732 charge swissprot:RHMR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RHMR_ECOLI eggNOG COG1414 http://eggnogapi.embl.de/nog_data/html/tree/COG1414 eggNOG ENOG4107258 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107258 epestfind swissprot:RHMR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RHMR_ECOLI garnier swissprot:RHMR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RHMR_ECOLI helixturnhelix swissprot:RHMR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RHMR_ECOLI hmoment swissprot:RHMR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RHMR_ECOLI iep swissprot:RHMR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RHMR_ECOLI inforesidue swissprot:RHMR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RHMR_ECOLI octanol swissprot:RHMR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RHMR_ECOLI pepcoil swissprot:RHMR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RHMR_ECOLI pepdigest swissprot:RHMR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RHMR_ECOLI pepinfo swissprot:RHMR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RHMR_ECOLI pepnet swissprot:RHMR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RHMR_ECOLI pepstats swissprot:RHMR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RHMR_ECOLI pepwheel swissprot:RHMR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RHMR_ECOLI pepwindow swissprot:RHMR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RHMR_ECOLI sigcleave swissprot:RHMR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RHMR_ECOLI ## Database ID URL or Descriptions # AltName PAAC_ECOLI 1,2-phenylacetyl-CoA epoxidase, structural subunit beta # AltName PAAC_ECOLI 1,2-phenylacetyl-CoA monooxygenase, subunit C # BRENDA 1.14.13.149 2026 # BioGrid 4260175 102 # EcoGene EG13737 paaC # FUNCTION PAAC_ECOLI Component of 1,2-phenylacetyl-CoA epoxidase multicomponent enzyme system which catalyzes the reduction of phenylacetyl-CoA (PA-CoA) to form 1,2-epoxyphenylacetyl-CoA. The subunit C may be essential for structural integrity of the alpha subunit. {ECO 0000269|PubMed 16997993, ECO 0000269|PubMed 20660314, ECO 0000269|PubMed 9748275}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_process GO:0010124 phenylacetate catabolic process; IMP:UniProtKB. # GOslim_component GO:0005829 cytosol # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.20.1260.10 -; 1. # INDUCTION PAAC_ECOLI Activated by cAMP receptor protein (CRP), integration host factor (IHF) and by phenylacetyl-coenzyme A (PA-CoA) that prevents PaaX from binding its target sequences. Inhibited by PaaX. {ECO 0000269|PubMed 10766858, ECO 0000269|PubMed 9748275}. # INTERACTION PAAC_ECOLI P0AEF4 dpiA; NbExp=4; IntAct=EBI-1131666, EBI-1119284; # IntAct P76079 7 # InterPro IPR007814 PaaA_PaaC # InterPro IPR009078 Ferritin-like_SF # InterPro IPR011882 PaaC # InterPro IPR012347 Ferritin-rel # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00360 Phenylalanine metabolism # Organism PAAC_ECOLI Escherichia coli (strain K12) # PATHWAY PAAC_ECOLI Aromatic compound metabolism; phenylacetate degradation. # PATRIC 32118066 VBIEscCol129921_1453 # PDB 1OTK X-ray; 2.00 A; A/B=2-248 # PDB 3PVR X-ray; 2.10 A; B/C=2-248 # PDB 3PVT X-ray; 2.03 A; B/C=2-248 # PDB 3PVY X-ray; 2.15 A; B/C=2-248 # PDB 3PW1 X-ray; 2.25 A; B/C=2-248 # PDB 3PW8 X-ray; 2.97 A; A/B=2-248 # PDB 3PWQ X-ray; 2.65 A; A/B/E/G/I/J/K/R=2-248 # PDB 4II4 X-ray; 2.80 A; B/C=2-248 # PIR A64890 A64890 # PIRSF PIRSF037834 PA_CoA_Oase3 # Pfam PF05138 PaaA_PaaC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PAAC_ECOLI 1,2-phenylacetyl-CoA epoxidase, subunit C # RefSeq NP_415908 NC_000913.3 # RefSeq WP_001072837 NZ_LN832404.1 # SUBUNIT PAAC_ECOLI Forms a stable heterotetramer (dimer of heterodimers) with PaaA and a stable heterodimer with PaaB. {ECO 0000269|PubMed 20823522, ECO 0000269|PubMed 21247899, ECO 0000269|Ref.8}. # SUPFAM SSF47240 SSF47240 # TIGRFAMs TIGR02158 PA_CoA_Oxy3 # eggNOG COG3396 LUCA # eggNOG ENOG4105D9S Bacteria BLAST swissprot:PAAC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PAAC_ECOLI BioCyc ECOL316407:JW1385-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1385-MONOMER BioCyc EcoCyc:G6711-MONOMER http://biocyc.org/getid?id=EcoCyc:G6711-MONOMER BioCyc MetaCyc:G6711-MONOMER http://biocyc.org/getid?id=MetaCyc:G6711-MONOMER COG COG3396 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3396 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.1005399107 http://dx.doi.org/10.1073/pnas.1005399107 DOI 10.1074/jbc.273.40.25974 http://dx.doi.org/10.1074/jbc.273.40.25974 DOI 10.1074/jbc.275.16.12214 http://dx.doi.org/10.1074/jbc.275.16.12214 DOI 10.1074/jbc.M110.194423 http://dx.doi.org/10.1074/jbc.M110.194423 DOI 10.1107/S174430911002748X http://dx.doi.org/10.1107/S174430911002748X DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AEM.01550-06 http://dx.doi.org/10.1128/AEM.01550-06 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X97452 http://www.ebi.ac.uk/ena/data/view/X97452 EchoBASE EB3500 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3500 EcoGene EG13737 http://www.ecogene.org/geneInfo.php?eg_id=EG13737 EnsemblBacteria AAC74472 http://www.ensemblgenomes.org/id/AAC74472 EnsemblBacteria AAC74472 http://www.ensemblgenomes.org/id/AAC74472 EnsemblBacteria BAE76425 http://www.ensemblgenomes.org/id/BAE76425 EnsemblBacteria BAE76425 http://www.ensemblgenomes.org/id/BAE76425 EnsemblBacteria BAE76425 http://www.ensemblgenomes.org/id/BAE76425 EnsemblBacteria b1390 http://www.ensemblgenomes.org/id/b1390 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_process GO:0010124 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010124 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.20.1260.10 http://www.cathdb.info/version/latest/superfamily/1.20.1260.10 GeneID 945956 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945956 HOGENOM HOG000254959 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000254959&db=HOGENOM6 InParanoid P76079 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76079 IntAct P76079 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76079* InterPro IPR007814 http://www.ebi.ac.uk/interpro/entry/IPR007814 InterPro IPR009078 http://www.ebi.ac.uk/interpro/entry/IPR009078 InterPro IPR011882 http://www.ebi.ac.uk/interpro/entry/IPR011882 InterPro IPR012347 http://www.ebi.ac.uk/interpro/entry/IPR012347 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1385 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1385 KEGG_Gene eco:b1390 http://www.genome.jp/dbget-bin/www_bget?eco:b1390 KEGG_Orthology KO:K02611 http://www.genome.jp/dbget-bin/www_bget?KO:K02611 KEGG_Pathway ko00360 http://www.genome.jp/kegg-bin/show_pathway?ko00360 KEGG_Reaction rn:R09838 http://www.genome.jp/dbget-bin/www_bget?rn:R09838 OMA AWCGHAP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AWCGHAP PDB 1OTK http://www.ebi.ac.uk/pdbe-srv/view/entry/1OTK PDB 3PVR http://www.ebi.ac.uk/pdbe-srv/view/entry/3PVR PDB 3PVT http://www.ebi.ac.uk/pdbe-srv/view/entry/3PVT PDB 3PVY http://www.ebi.ac.uk/pdbe-srv/view/entry/3PVY PDB 3PW1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3PW1 PDB 3PW8 http://www.ebi.ac.uk/pdbe-srv/view/entry/3PW8 PDB 3PWQ http://www.ebi.ac.uk/pdbe-srv/view/entry/3PWQ PDB 4II4 http://www.ebi.ac.uk/pdbe-srv/view/entry/4II4 PDBsum 1OTK http://www.ebi.ac.uk/pdbsum/1OTK PDBsum 3PVR http://www.ebi.ac.uk/pdbsum/3PVR PDBsum 3PVT http://www.ebi.ac.uk/pdbsum/3PVT PDBsum 3PVY http://www.ebi.ac.uk/pdbsum/3PVY PDBsum 3PW1 http://www.ebi.ac.uk/pdbsum/3PW1 PDBsum 3PW8 http://www.ebi.ac.uk/pdbsum/3PW8 PDBsum 3PWQ http://www.ebi.ac.uk/pdbsum/3PWQ PDBsum 4II4 http://www.ebi.ac.uk/pdbsum/4II4 PSORT swissprot:PAAC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PAAC_ECOLI PSORT-B swissprot:PAAC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PAAC_ECOLI PSORT2 swissprot:PAAC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PAAC_ECOLI Pfam PF05138 http://pfam.xfam.org/family/PF05138 Phobius swissprot:PAAC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PAAC_ECOLI PhylomeDB P76079 http://phylomedb.org/?seqid=P76079 ProteinModelPortal P76079 http://www.proteinmodelportal.org/query/uniprot/P76079 PubMed 10766858 http://www.ncbi.nlm.nih.gov/pubmed/10766858 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16997993 http://www.ncbi.nlm.nih.gov/pubmed/16997993 PubMed 20660314 http://www.ncbi.nlm.nih.gov/pubmed/20660314 PubMed 20823522 http://www.ncbi.nlm.nih.gov/pubmed/20823522 PubMed 21247899 http://www.ncbi.nlm.nih.gov/pubmed/21247899 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9748275 http://www.ncbi.nlm.nih.gov/pubmed/9748275 RefSeq NP_415908 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415908 RefSeq WP_001072837 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001072837 SMR P76079 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76079 STRING 511145.b1390 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1390&targetmode=cogs STRING COG3396 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3396&targetmode=cogs SUPFAM SSF47240 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47240 TIGRFAMs TIGR02158 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02158 UniProtKB PAAC_ECOLI http://www.uniprot.org/uniprot/PAAC_ECOLI UniProtKB-AC P76079 http://www.uniprot.org/uniprot/P76079 charge swissprot:PAAC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PAAC_ECOLI eggNOG COG3396 http://eggnogapi.embl.de/nog_data/html/tree/COG3396 eggNOG ENOG4105D9S http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D9S epestfind swissprot:PAAC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PAAC_ECOLI garnier swissprot:PAAC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PAAC_ECOLI helixturnhelix swissprot:PAAC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PAAC_ECOLI hmoment swissprot:PAAC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PAAC_ECOLI iep swissprot:PAAC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PAAC_ECOLI inforesidue swissprot:PAAC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PAAC_ECOLI octanol swissprot:PAAC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PAAC_ECOLI pepcoil swissprot:PAAC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PAAC_ECOLI pepdigest swissprot:PAAC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PAAC_ECOLI pepinfo swissprot:PAAC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PAAC_ECOLI pepnet swissprot:PAAC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PAAC_ECOLI pepstats swissprot:PAAC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PAAC_ECOLI pepwheel swissprot:PAAC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PAAC_ECOLI pepwindow swissprot:PAAC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PAAC_ECOLI sigcleave swissprot:PAAC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PAAC_ECOLI ## Database ID URL or Descriptions # BRENDA 2.7.13 2026 # BioGrid 4262583 14 # CATALYTIC ACTIVITY UHPB_ECOLI ATP + protein L-histidine = ADP + protein N- phospho-L-histidine. {ECO 0000269|PubMed 11053370, ECO 0000269|PubMed 11739766}. # ENZYME REGULATION Kinase activity is stimulated by UhpC. {ECO:0000269|PubMed 11053370}. # EcoGene EG11052 uhpB # FUNCTION UHPB_ECOLI Part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpB functions as a membrane-associated protein kinase that autophosphorylates in response to interaction with UhpC, and subsequently transfers its phosphate group to the response regulator UhpA (PubMed 3038843, PubMed 8349544, PubMed 11053370, PubMed 11739766). Can also dephosphorylate UhpA (PubMed 11053370, PubMed 11739766). {ECO 0000269|PubMed 11053370, ECO 0000269|PubMed 11739766, ECO 0000269|PubMed 3038843, ECO 0000269|PubMed 8349544}. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0000155 phosphorelay sensor kinase activity; IDA:EcoCyc. # GO_function GO:0004721 phosphoprotein phosphatase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0000160 phosphorelay signal transduction system; IDA:EcoCyc. # GO_process GO:0046777 protein autophosphorylation; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005622 intracellular # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0007165 signal transduction # Gene3D 3.30.565.10 -; 1. # InterPro IPR003594 HATPase_C # InterPro IPR005467 His_kinase_dom # InterPro IPR007895 MASE1 # InterPro IPR011712 Sig_transdc_His_kin_sub3_dim/P # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01001 Protein kinases # KEGG_Brite ko02022 M00473 UhpB-UhpA (hexose phosphates uptake) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # Organism UHPB_ECOLI Escherichia coli (strain K12) # PATRIC 32122829 VBIEscCol129921_3790 # PIR E65168 RGECUB # PROSITE PS50109 HIS_KIN # PTM UHPB_ECOLI Autophosphorylated. {ECO 0000269|PubMed 11053370, ECO 0000269|PubMed 11739766}. # Pfam PF02518 HATPase_c # Pfam PF05231 MASE1 # Pfam PF07730 HisKA_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Signal transduction histidine-protein kinase/phosphatase UhpB {ECO 0000305} # RefSeq NP_418124 NC_000913.3 # RefSeq WP_001295243 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA62020.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Contains 1 histidine kinase domain. {ECO:0000255|PROSITE-ProRule PRU00107}. # SMART SM00387 HATPase_c # SUBCELLULAR LOCATION UHPB_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255}. # SUPFAM SSF55874 SSF55874 # eggNOG ENOG4105BZU Bacteria # eggNOG ENOG410XNMH LUCA BLAST swissprot:UHPB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UHPB_ECOLI BioCyc ECOL316407:JW3643-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3643-MONOMER BioCyc EcoCyc:UHPB-MONOMER http://biocyc.org/getid?id=EcoCyc:UHPB-MONOMER COG COG3851 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3851 DIP DIP-11083N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11083N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1099/00221287-147-12-3345 http://dx.doi.org/10.1099/00221287-147-12-3345 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.22.6279-6286.2000 http://dx.doi.org/10.1128/JB.182.22.6279-6286.2000 EC_number EC:2.7.13.3 {ECO:0000269|PubMed:11053370, ECO:0000269|PubMed:11739766} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.13.3 {ECO:0000269|PubMed:11053370, ECO:0000269|PubMed:11739766} EC_number EC:3.1.3.- {ECO:0000269|PubMed:11739766} http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.- {ECO:0000269|PubMed:11739766} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M17102 http://www.ebi.ac.uk/ena/data/view/M17102 EMBL M89479 http://www.ebi.ac.uk/ena/data/view/M89479 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.13.3 {ECO:0000269|PubMed:11053370, ECO:0000269|PubMed:11739766} http://enzyme.expasy.org/EC/2.7.13.3 {ECO:0000269|PubMed:11053370, ECO:0000269|PubMed:11739766} ENZYME 3.1.3.- {ECO:0000269|PubMed:11739766} http://enzyme.expasy.org/EC/3.1.3.- {ECO:0000269|PubMed:11739766} EchoBASE EB1045 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1045 EcoGene EG11052 http://www.ecogene.org/geneInfo.php?eg_id=EG11052 EnsemblBacteria AAC76691 http://www.ensemblgenomes.org/id/AAC76691 EnsemblBacteria AAC76691 http://www.ensemblgenomes.org/id/AAC76691 EnsemblBacteria BAE77625 http://www.ensemblgenomes.org/id/BAE77625 EnsemblBacteria BAE77625 http://www.ensemblgenomes.org/id/BAE77625 EnsemblBacteria BAE77625 http://www.ensemblgenomes.org/id/BAE77625 EnsemblBacteria b3668 http://www.ensemblgenomes.org/id/b3668 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0000155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000155 GO_function GO:0004721 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004721 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0046777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046777 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 Gene3D 3.30.565.10 http://www.cathdb.info/version/latest/superfamily/3.30.565.10 GeneID 948195 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948195 HOGENOM HOG000280063 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000280063&db=HOGENOM6 InParanoid P09835 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P09835 IntEnz 2.7.13.3 {ECO:0000269|PubMed:11053370, ECO:0000269|PubMed:11739766} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.13.3 {ECO:0000269|PubMed:11053370, ECO:0000269|PubMed:11739766} IntEnz 3.1.3.- {ECO:0000269|PubMed:11739766} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.- {ECO:0000269|PubMed:11739766} InterPro IPR003594 http://www.ebi.ac.uk/interpro/entry/IPR003594 InterPro IPR005467 http://www.ebi.ac.uk/interpro/entry/IPR005467 InterPro IPR007895 http://www.ebi.ac.uk/interpro/entry/IPR007895 InterPro IPR011712 http://www.ebi.ac.uk/interpro/entry/IPR011712 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01001 http://www.genome.jp/dbget-bin/www_bget?ko01001 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW3643 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3643 KEGG_Gene eco:b3668 http://www.genome.jp/dbget-bin/www_bget?eco:b3668 KEGG_Orthology KO:K07675 http://www.genome.jp/dbget-bin/www_bget?KO:K07675 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA GEAAWNA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GEAAWNA PROSITE PS50109 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50109 PSORT swissprot:UHPB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UHPB_ECOLI PSORT-B swissprot:UHPB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UHPB_ECOLI PSORT2 swissprot:UHPB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UHPB_ECOLI Pfam PF02518 http://pfam.xfam.org/family/PF02518 Pfam PF05231 http://pfam.xfam.org/family/PF05231 Pfam PF07730 http://pfam.xfam.org/family/PF07730 Phobius swissprot:UHPB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UHPB_ECOLI ProteinModelPortal P09835 http://www.proteinmodelportal.org/query/uniprot/P09835 PubMed 11053370 http://www.ncbi.nlm.nih.gov/pubmed/11053370 PubMed 11739766 http://www.ncbi.nlm.nih.gov/pubmed/11739766 PubMed 1569007 http://www.ncbi.nlm.nih.gov/pubmed/1569007 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3038843 http://www.ncbi.nlm.nih.gov/pubmed/3038843 PubMed 3301805 http://www.ncbi.nlm.nih.gov/pubmed/3301805 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 8349544 http://www.ncbi.nlm.nih.gov/pubmed/8349544 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418124 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418124 RefSeq WP_001295243 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295243 SMART SM00387 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00387 SMR P09835 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P09835 STRING 511145.b3668 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3668&targetmode=cogs STRING COG3851 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3851&targetmode=cogs SUPFAM SSF55874 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55874 UniProtKB UHPB_ECOLI http://www.uniprot.org/uniprot/UHPB_ECOLI UniProtKB-AC P09835 http://www.uniprot.org/uniprot/P09835 charge swissprot:UHPB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UHPB_ECOLI eggNOG ENOG4105BZU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZU eggNOG ENOG410XNMH http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNMH epestfind swissprot:UHPB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UHPB_ECOLI garnier swissprot:UHPB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UHPB_ECOLI helixturnhelix swissprot:UHPB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UHPB_ECOLI hmoment swissprot:UHPB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UHPB_ECOLI iep swissprot:UHPB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UHPB_ECOLI inforesidue swissprot:UHPB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UHPB_ECOLI octanol swissprot:UHPB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UHPB_ECOLI pepcoil swissprot:UHPB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UHPB_ECOLI pepdigest swissprot:UHPB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UHPB_ECOLI pepinfo swissprot:UHPB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UHPB_ECOLI pepnet swissprot:UHPB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UHPB_ECOLI pepstats swissprot:UHPB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UHPB_ECOLI pepwheel swissprot:UHPB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UHPB_ECOLI pepwindow swissprot:UHPB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UHPB_ECOLI sigcleave swissprot:UHPB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UHPB_ECOLI ## Database ID URL or Descriptions # AltName TUSA_ECOLI tRNA 2-thiouridine synthesizing protein A # CDD cd03423 SirA # EcoGene EG12216 tusA # FUNCTION TUSA_ECOLI Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD. Seems to affect the stability of sigma-S, particularly during the logarithmic growth phase. {ECO 0000269|PubMed 16387657}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0016783 sulfurtransferase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0097163 sulfur carrier activity; IDA:EcoCyc. # GO_process GO:0002143 tRNA wobble position uridine thiolation; IMP:EcoCyc. # GO_process GO:0006777 Mo-molybdopterin cofactor biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.30.110.40 -; 1. # HAMAP MF_00413 Thiourid_synth_A # INTERACTION TUSA_ECOLI P0A6B7 iscS; NbExp=5; IntAct=EBI-561780, EBI-550055; # IntAct P0A890 16 # InterPro IPR001455 TusA-like # InterPro IPR022931 Sulphurtransferase_TusA # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # KEGG_Pathway ko04122 Sulfur relay system # Organism TUSA_ECOLI Escherichia coli (strain K12) # PATRIC 32122384 VBIEscCol129921_3569 # PDB 1DCJ NMR; -; A=1-81 # PIR S47689 S47689 # PROSITE PS01148 UPF0033 # Pfam PF01206 TusA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TUSA_ECOLI Sulfurtransferase TusA # RefSeq NP_417927 NC_000913.3 # RefSeq WP_000130621 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0033 family. TusA subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION TUSA_ECOLI Cytoplasm. # SUBUNIT Interacts with IscS. {ECO:0000269|PubMed 16387657}. # SUPFAM SSF64307 SSF64307 # eggNOG COG0425 LUCA # eggNOG ENOG41082K8 Bacteria BLAST swissprot:TUSA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TUSA_ECOLI BioCyc ECOL316407:JW3435-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3435-MONOMER BioCyc EcoCyc:EG12216-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12216-MONOMER BioCyc MetaCyc:EG12216-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12216-MONOMER COG COG0425 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0425 DIP DIP-48202N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48202N DOI 10.1006/jmbi.2000.4170 http://dx.doi.org/10.1006/jmbi.2000.4170 DOI 10.1016/j.molcel.2005.11.001 http://dx.doi.org/10.1016/j.molcel.2005.11.001 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1271/bbb.64.799 http://dx.doi.org/10.1271/bbb.64.799 EC_number EC:2.8.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.8.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.8.1.- http://enzyme.expasy.org/EC/2.8.1.- EchoBASE EB2130 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2130 EcoGene EG12216 http://www.ecogene.org/geneInfo.php?eg_id=EG12216 EnsemblBacteria AAC76495 http://www.ensemblgenomes.org/id/AAC76495 EnsemblBacteria AAC76495 http://www.ensemblgenomes.org/id/AAC76495 EnsemblBacteria BAE77823 http://www.ensemblgenomes.org/id/BAE77823 EnsemblBacteria BAE77823 http://www.ensemblgenomes.org/id/BAE77823 EnsemblBacteria BAE77823 http://www.ensemblgenomes.org/id/BAE77823 EnsemblBacteria b3470 http://www.ensemblgenomes.org/id/b3470 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0016783 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016783 GO_function GO:0097163 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097163 GO_process GO:0002143 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002143 GO_process GO:0006777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006777 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.30.110.40 http://www.cathdb.info/version/latest/superfamily/3.30.110.40 GeneID 947974 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947974 HAMAP MF_00413 http://hamap.expasy.org/unirule/MF_00413 HOGENOM HOG000259291 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000259291&db=HOGENOM6 InParanoid P0A890 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A890 IntAct P0A890 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A890* IntEnz 2.8.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.8.1 InterPro IPR001455 http://www.ebi.ac.uk/interpro/entry/IPR001455 InterPro IPR022931 http://www.ebi.ac.uk/interpro/entry/IPR022931 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW3435 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3435 KEGG_Gene eco:b3470 http://www.genome.jp/dbget-bin/www_bget?eco:b3470 KEGG_Orthology KO:K04085 http://www.genome.jp/dbget-bin/www_bget?KO:K04085 KEGG_Pathway ko04122 http://www.genome.jp/kegg-bin/show_pathway?ko04122 OMA VRQMETG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VRQMETG PDB 1DCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1DCJ PDBsum 1DCJ http://www.ebi.ac.uk/pdbsum/1DCJ PROSITE PS01148 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01148 PSORT swissprot:TUSA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TUSA_ECOLI PSORT-B swissprot:TUSA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TUSA_ECOLI PSORT2 swissprot:TUSA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TUSA_ECOLI Pfam PF01206 http://pfam.xfam.org/family/PF01206 Phobius swissprot:TUSA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TUSA_ECOLI PhylomeDB P0A890 http://phylomedb.org/?seqid=P0A890 ProteinModelPortal P0A890 http://www.proteinmodelportal.org/query/uniprot/P0A890 PubMed 10830496 http://www.ncbi.nlm.nih.gov/pubmed/10830496 PubMed 11080457 http://www.ncbi.nlm.nih.gov/pubmed/11080457 PubMed 16387657 http://www.ncbi.nlm.nih.gov/pubmed/16387657 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9555915 http://www.ncbi.nlm.nih.gov/pubmed/9555915 RefSeq NP_417927 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417927 RefSeq WP_000130621 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000130621 SMR P0A890 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A890 STRING 511145.b3470 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3470&targetmode=cogs STRING COG0425 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0425&targetmode=cogs SUPFAM SSF64307 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF64307 UniProtKB TUSA_ECOLI http://www.uniprot.org/uniprot/TUSA_ECOLI UniProtKB-AC P0A890 http://www.uniprot.org/uniprot/P0A890 charge swissprot:TUSA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TUSA_ECOLI eggNOG COG0425 http://eggnogapi.embl.de/nog_data/html/tree/COG0425 eggNOG ENOG41082K8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41082K8 epestfind swissprot:TUSA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TUSA_ECOLI garnier swissprot:TUSA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TUSA_ECOLI helixturnhelix swissprot:TUSA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TUSA_ECOLI hmoment swissprot:TUSA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TUSA_ECOLI iep swissprot:TUSA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TUSA_ECOLI inforesidue swissprot:TUSA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TUSA_ECOLI octanol swissprot:TUSA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TUSA_ECOLI pepcoil swissprot:TUSA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TUSA_ECOLI pepdigest swissprot:TUSA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TUSA_ECOLI pepinfo swissprot:TUSA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TUSA_ECOLI pepnet swissprot:TUSA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TUSA_ECOLI pepstats swissprot:TUSA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TUSA_ECOLI pepwheel swissprot:TUSA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TUSA_ECOLI pepwindow swissprot:TUSA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TUSA_ECOLI sigcleave swissprot:TUSA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TUSA_ECOLI ## Database ID URL or Descriptions # EcoGene EG12230 pitA # FUNCTION PITA_ECOLI Low-affinity inorganic phosphate transport. Can also transport arsenate. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; ISM:EcoCyc. # GO_function GO:0005315 inorganic phosphate transmembrane transporter activity; IMP:EcoCyc. # GO_function GO:0005385 zinc ion transmembrane transporter activity; IMP:EcoCyc. # GO_function GO:0015654 tellurite uptake transmembrane transporter activity; IMP:EcoCyc. # GO_function PITA_ECOLI GO 0015295 solute proton symporter activity; IDA EcoCyc. # GO_process GO:0015710 tellurite transport; IMP:EcoCyc. # GO_process GO:0035435 phosphate ion transmembrane transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # InterPro IPR001204 Phos_transporter # KEGG_Brite ko02000 Transporters # Organism PITA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11101 PTHR11101 # PATRIC 32122434 VBIEscCol129921_3594 # PIR S47713 S47713 # Pfam PF01384 PHO4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PITA_ECOLI Low-affinity inorganic phosphate transporter 1 # RefSeq NP_417950 NC_000913.3 # RefSeq WP_000902780 NZ_LN832404.1 # SIMILARITY Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. Pit subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION PITA_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.20.1 the inorganic phosphate transporter (pit) family # eggNOG COG0306 LUCA # eggNOG ENOG4105CJ3 Bacteria BLAST swissprot:PITA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PITA_ECOLI BioCyc ECOL316407:JW3460-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3460-MONOMER BioCyc EcoCyc:PITA-MONOMER http://biocyc.org/getid?id=EcoCyc:PITA-MONOMER BioCyc MetaCyc:PITA-MONOMER http://biocyc.org/getid?id=MetaCyc:PITA-MONOMER COG COG0306 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0306 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2142 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2142 EcoGene EG12230 http://www.ecogene.org/geneInfo.php?eg_id=EG12230 EnsemblBacteria AAC76518 http://www.ensemblgenomes.org/id/AAC76518 EnsemblBacteria AAC76518 http://www.ensemblgenomes.org/id/AAC76518 EnsemblBacteria BAE77801 http://www.ensemblgenomes.org/id/BAE77801 EnsemblBacteria BAE77801 http://www.ensemblgenomes.org/id/BAE77801 EnsemblBacteria BAE77801 http://www.ensemblgenomes.org/id/BAE77801 EnsemblBacteria b3493 http://www.ensemblgenomes.org/id/b3493 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0005315 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005315 GO_function GO:0005385 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005385 GO_function GO:0015295 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015295 GO_function GO:0015654 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015654 GO_process GO:0015710 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015710 GO_process GO:0035435 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035435 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 948009 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948009 HOGENOM HOG000231893 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231893&db=HOGENOM6 InParanoid P0AFJ7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFJ7 InterPro IPR001204 http://www.ebi.ac.uk/interpro/entry/IPR001204 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3460 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3460 KEGG_Gene eco:b3493 http://www.genome.jp/dbget-bin/www_bget?eco:b3493 KEGG_Orthology KO:K16322 http://www.genome.jp/dbget-bin/www_bget?KO:K16322 OMA YDITRTR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YDITRTR PANTHER PTHR11101 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11101 PSORT swissprot:PITA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PITA_ECOLI PSORT-B swissprot:PITA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PITA_ECOLI PSORT2 swissprot:PITA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PITA_ECOLI Pfam PF01384 http://pfam.xfam.org/family/PF01384 Phobius swissprot:PITA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PITA_ECOLI PhylomeDB P0AFJ7 http://phylomedb.org/?seqid=P0AFJ7 ProteinModelPortal P0AFJ7 http://www.proteinmodelportal.org/query/uniprot/P0AFJ7 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417950 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417950 RefSeq WP_000902780 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000902780 STRING 511145.b3493 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3493&targetmode=cogs STRING COG0306 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0306&targetmode=cogs TCDB 2.A.20.1 http://www.tcdb.org/search/result.php?tc=2.A.20.1 UniProtKB PITA_ECOLI http://www.uniprot.org/uniprot/PITA_ECOLI UniProtKB-AC P0AFJ7 http://www.uniprot.org/uniprot/P0AFJ7 charge swissprot:PITA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PITA_ECOLI eggNOG COG0306 http://eggnogapi.embl.de/nog_data/html/tree/COG0306 eggNOG ENOG4105CJ3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CJ3 epestfind swissprot:PITA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PITA_ECOLI garnier swissprot:PITA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PITA_ECOLI helixturnhelix swissprot:PITA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PITA_ECOLI hmoment swissprot:PITA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PITA_ECOLI iep swissprot:PITA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PITA_ECOLI inforesidue swissprot:PITA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PITA_ECOLI octanol swissprot:PITA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PITA_ECOLI pepcoil swissprot:PITA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PITA_ECOLI pepdigest swissprot:PITA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PITA_ECOLI pepinfo swissprot:PITA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PITA_ECOLI pepnet swissprot:PITA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PITA_ECOLI pepstats swissprot:PITA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PITA_ECOLI pepwheel swissprot:PITA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PITA_ECOLI pepwindow swissprot:PITA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PITA_ECOLI sigcleave swissprot:PITA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PITA_ECOLI ## Database ID URL or Descriptions # AltName FLGM_ECOLI Anti-sigma-28 factor # EcoGene EG12664 flgM # FUNCTION FLGM_ECOLI Responsible for the coupling of flagellin expression to flagellar assembly by preventing expression of the flagellin genes when a component of the middle class of proteins is defective. It negatively regulates flagellar genes by inhibiting the activity of FliA by directly binding to FliA. # GO_function GO:0016989 sigma factor antagonist activity; IMP:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0044781 bacterial-type flagellum organization; IEA:UniProtKB-KW. # GO_process GO:0045861 negative regulation of proteolysis; IMP:EcoCyc. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IEA:InterPro. # GOslim_function GO:0000988 transcription factor activity, protein binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # INTERACTION FLGM_ECOLI P0AEM6 fliA; NbExp=4; IntAct=EBI-1121952, EBI-549807; # IntAct P0AEM4 13 # InterPro IPR007412 FlgM # InterPro IPR031316 FlgM_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Pathway ko02040 Flagellar assembly # Organism FLGM_ECOLI Escherichia coli (strain K12) # PATRIC 32117381 VBIEscCol129921_1113 # PIR D64850 D64850 # Pfam PF04316 FlgM # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FLGM_ECOLI Negative regulator of flagellin synthesis # RefSeq NP_415589 NC_000913.3 # RefSeq WP_000020880 NZ_LN832404.1 # SIMILARITY Belongs to the FlgM family. {ECO 0000305}. # SUPFAM SSF101498 SSF101498 # TIGRFAMs TIGR03824 FlgM_jcvi # eggNOG COG2747 LUCA # eggNOG ENOG4105M9M Bacteria BLAST swissprot:FLGM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLGM_ECOLI BioCyc ECOL316407:JW1058-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1058-MONOMER BioCyc EcoCyc:G369-MONOMER http://biocyc.org/getid?id=EcoCyc:G369-MONOMER COG COG2747 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2747 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb0497-285 http://dx.doi.org/10.1038/nsb0497-285 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U19773 http://www.ebi.ac.uk/ena/data/view/U19773 EchoBASE EB2530 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2530 EcoGene EG12664 http://www.ecogene.org/geneInfo.php?eg_id=EG12664 EnsemblBacteria AAC74155 http://www.ensemblgenomes.org/id/AAC74155 EnsemblBacteria AAC74155 http://www.ensemblgenomes.org/id/AAC74155 EnsemblBacteria BAA35879 http://www.ensemblgenomes.org/id/BAA35879 EnsemblBacteria BAA35879 http://www.ensemblgenomes.org/id/BAA35879 EnsemblBacteria BAA35879 http://www.ensemblgenomes.org/id/BAA35879 EnsemblBacteria b1071 http://www.ensemblgenomes.org/id/b1071 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016989 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016989 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0044781 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044781 GO_process GO:0045861 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045861 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_function GO:0000988 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000988 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 946684 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946684 HOGENOM HOG000265658 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000265658&db=HOGENOM6 IntAct P0AEM4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEM4* InterPro IPR007412 http://www.ebi.ac.uk/interpro/entry/IPR007412 InterPro IPR031316 http://www.ebi.ac.uk/interpro/entry/IPR031316 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW1058 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1058 KEGG_Gene eco:b1071 http://www.genome.jp/dbget-bin/www_bget?eco:b1071 KEGG_Orthology KO:K02398 http://www.genome.jp/dbget-bin/www_bget?KO:K02398 KEGG_Pathway ko02040 http://www.genome.jp/kegg-bin/show_pathway?ko02040 OMA TQDIDMN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TQDIDMN PSORT swissprot:FLGM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLGM_ECOLI PSORT-B swissprot:FLGM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLGM_ECOLI PSORT2 swissprot:FLGM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLGM_ECOLI Pfam PF04316 http://pfam.xfam.org/family/PF04316 Phobius swissprot:FLGM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLGM_ECOLI ProteinModelPortal P0AEM4 http://www.proteinmodelportal.org/query/uniprot/P0AEM4 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9095196 http://www.ncbi.nlm.nih.gov/pubmed/9095196 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415589 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415589 RefSeq WP_000020880 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000020880 STRING 511145.b1071 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1071&targetmode=cogs STRING COG2747 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2747&targetmode=cogs SUPFAM SSF101498 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF101498 TIGRFAMs TIGR03824 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03824 UniProtKB FLGM_ECOLI http://www.uniprot.org/uniprot/FLGM_ECOLI UniProtKB-AC P0AEM4 http://www.uniprot.org/uniprot/P0AEM4 charge swissprot:FLGM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLGM_ECOLI eggNOG COG2747 http://eggnogapi.embl.de/nog_data/html/tree/COG2747 eggNOG ENOG4105M9M http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105M9M epestfind swissprot:FLGM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLGM_ECOLI garnier swissprot:FLGM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLGM_ECOLI helixturnhelix swissprot:FLGM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLGM_ECOLI hmoment swissprot:FLGM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLGM_ECOLI iep swissprot:FLGM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLGM_ECOLI inforesidue swissprot:FLGM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLGM_ECOLI octanol swissprot:FLGM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLGM_ECOLI pepcoil swissprot:FLGM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLGM_ECOLI pepdigest swissprot:FLGM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLGM_ECOLI pepinfo swissprot:FLGM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLGM_ECOLI pepnet swissprot:FLGM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLGM_ECOLI pepstats swissprot:FLGM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLGM_ECOLI pepwheel swissprot:FLGM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLGM_ECOLI pepwindow swissprot:FLGM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLGM_ECOLI sigcleave swissprot:FLGM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLGM_ECOLI ## Database ID URL or Descriptions # AltName GFCC_ECOLI Group 4 capsule protein C homolog # BioGrid 4261410 21 # CAUTION In E.coli K12 / MG1655 and K12 / W3110 this operon is silenced by an IS1D insertion in the promoter region. {ECO 0000305}. # EcoGene EG13730 gfcC # IntAct P75883 5 # InterPro IPR010425 DUF1017 # Organism GFCC_ECOLI Escherichia coli (strain K12) # PATRIC 32117193 VBIEscCol129921_1020 # PIR G64839 G64839 # Pfam PF06251 Caps_synth_GfcC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GFCC_ECOLI Uncharacterized protein GfcC # RefSeq NP_415505 NC_000913.3 # RefSeq WP_001038079 NZ_LN832404.1 # SIMILARITY To E.coli YjbG. {ECO 0000305}. # eggNOG ENOG4108W78 Bacteria # eggNOG ENOG4111IU0 LUCA BLAST swissprot:GFCC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GFCC_ECOLI BioCyc ECOL316407:JW0968-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0968-MONOMER BioCyc EcoCyc:G6506-MONOMER http://biocyc.org/getid?id=EcoCyc:G6506-MONOMER DIP DIP-12708N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12708N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3494 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3494 EcoGene EG13730 http://www.ecogene.org/geneInfo.php?eg_id=EG13730 EnsemblBacteria AAC74070 http://www.ensemblgenomes.org/id/AAC74070 EnsemblBacteria AAC74070 http://www.ensemblgenomes.org/id/AAC74070 EnsemblBacteria BAA35750 http://www.ensemblgenomes.org/id/BAA35750 EnsemblBacteria BAA35750 http://www.ensemblgenomes.org/id/BAA35750 EnsemblBacteria BAA35750 http://www.ensemblgenomes.org/id/BAA35750 EnsemblBacteria b0985 http://www.ensemblgenomes.org/id/b0985 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 944978 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944978 HOGENOM HOG000126863 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126863&db=HOGENOM6 IntAct P75883 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75883* InterPro IPR010425 http://www.ebi.ac.uk/interpro/entry/IPR010425 KEGG_Gene ecj:JW0968 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0968 KEGG_Gene eco:b0985 http://www.genome.jp/dbget-bin/www_bget?eco:b0985 MINT MINT-1302737 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1302737 OMA WWPGTAI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WWPGTAI PSORT swissprot:GFCC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GFCC_ECOLI PSORT-B swissprot:GFCC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GFCC_ECOLI PSORT2 swissprot:GFCC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GFCC_ECOLI Pfam PF06251 http://pfam.xfam.org/family/PF06251 Phobius swissprot:GFCC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GFCC_ECOLI ProteinModelPortal P75883 http://www.proteinmodelportal.org/query/uniprot/P75883 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415505 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415505 RefSeq WP_001038079 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001038079 SMR P75883 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75883 STRING 511145.b0985 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0985&targetmode=cogs UniProtKB GFCC_ECOLI http://www.uniprot.org/uniprot/GFCC_ECOLI UniProtKB-AC P75883 http://www.uniprot.org/uniprot/P75883 charge swissprot:GFCC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GFCC_ECOLI eggNOG ENOG4108W78 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108W78 eggNOG ENOG4111IU0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111IU0 epestfind swissprot:GFCC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GFCC_ECOLI garnier swissprot:GFCC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GFCC_ECOLI helixturnhelix swissprot:GFCC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GFCC_ECOLI hmoment swissprot:GFCC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GFCC_ECOLI iep swissprot:GFCC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GFCC_ECOLI inforesidue swissprot:GFCC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GFCC_ECOLI octanol swissprot:GFCC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GFCC_ECOLI pepcoil swissprot:GFCC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GFCC_ECOLI pepdigest swissprot:GFCC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GFCC_ECOLI pepinfo swissprot:GFCC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GFCC_ECOLI pepnet swissprot:GFCC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GFCC_ECOLI pepstats swissprot:GFCC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GFCC_ECOLI pepwheel swissprot:GFCC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GFCC_ECOLI pepwindow swissprot:GFCC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GFCC_ECOLI sigcleave swissprot:GFCC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GFCC_ECOLI ## Database ID URL or Descriptions # EcoGene EG11167 zupT # FUNCTION ZUPT_ECOLI Mediates zinc uptake. May also transport other divalent cations such as copper and cadmium ions. {ECO 0000269|PubMed 11790762}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005384 manganese ion transmembrane transporter activity; IMP:EcoCyc. # GO_function GO:0005385 zinc ion transmembrane transporter activity; IBA:GO_Central. # GO_function GO:0015086 cadmium ion transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0015087 cobalt ion transmembrane transporter activity; IGI:EcoCyc. # GO_function GO:0015088 copper uptake transmembrane transporter activity; IMP:EcoCyc. # GO_function GO:0015093 ferrous iron transmembrane transporter activity; IGI:EcoCyc. # GO_process GO:0006829 zinc II ion transport; IMP:CACAO. # GO_process GO:0070574 cadmium ion transmembrane transport; IDA:EcoCyc. # GO_process GO:0071577 zinc II ion transmembrane transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # HAMAP MF_00548 ZupT # InterPro IPR003689 ZIP # InterPro IPR023498 Zn_transptr_ZupT # KEGG_Brite ko02000 Transporters # Organism ZUPT_ECOLI Escherichia coli (strain K12) # PATRIC 32121490 VBIEscCol129921_3132 # PIR S22363 S22363 # Pfam PF02535 Zip # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ZUPT_ECOLI Zinc transporter ZupT # RefSeq NP_417512 NC_000913.3 # RefSeq WP_001295627 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA69208.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION ZUPT_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # TCDB 2.A.5.5 the zinc (zn(2+))-iron (fe(2+)) permease (zip) family # eggNOG COG0428 LUCA # eggNOG ENOG4105DUN Bacteria BLAST swissprot:ZUPT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ZUPT_ECOLI BioCyc ECOL316407:JW3008-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3008-MONOMER BioCyc EcoCyc:EG11167-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11167-MONOMER BioCyc MetaCyc:EG11167-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11167-MONOMER COG COG0428 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0428 DOI 10.1016/0167-4781(92)90535-8 http://dx.doi.org/10.1016/0167-4781(92)90535-8 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.3.864-866.2002 http://dx.doi.org/10.1128/JB.184.3.864-866.2002 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M77129 http://www.ebi.ac.uk/ena/data/view/M77129 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB1155 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1155 EcoGene EG11167 http://www.ecogene.org/geneInfo.php?eg_id=EG11167 EnsemblBacteria AAC76076 http://www.ensemblgenomes.org/id/AAC76076 EnsemblBacteria AAC76076 http://www.ensemblgenomes.org/id/AAC76076 EnsemblBacteria BAE77096 http://www.ensemblgenomes.org/id/BAE77096 EnsemblBacteria BAE77096 http://www.ensemblgenomes.org/id/BAE77096 EnsemblBacteria BAE77096 http://www.ensemblgenomes.org/id/BAE77096 EnsemblBacteria b3040 http://www.ensemblgenomes.org/id/b3040 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005384 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005384 GO_function GO:0005385 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005385 GO_function GO:0015086 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015086 GO_function GO:0015087 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015087 GO_function GO:0015088 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015088 GO_function GO:0015093 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015093 GO_process GO:0006829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006829 GO_process GO:0070574 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070574 GO_process GO:0071577 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071577 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 947035 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947035 HAMAP MF_00548 http://hamap.expasy.org/unirule/MF_00548 HOGENOM HOG000232704 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000232704&db=HOGENOM6 InParanoid P0A8H3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8H3 InterPro IPR003689 http://www.ebi.ac.uk/interpro/entry/IPR003689 InterPro IPR023498 http://www.ebi.ac.uk/interpro/entry/IPR023498 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3008 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3008 KEGG_Gene eco:b3040 http://www.genome.jp/dbget-bin/www_bget?eco:b3040 KEGG_Orthology KO:K07238 http://www.genome.jp/dbget-bin/www_bget?KO:K07238 OMA MIVASFT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MIVASFT PSORT swissprot:ZUPT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ZUPT_ECOLI PSORT-B swissprot:ZUPT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ZUPT_ECOLI PSORT2 swissprot:ZUPT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ZUPT_ECOLI Pfam PF02535 http://pfam.xfam.org/family/PF02535 Phobius swissprot:ZUPT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ZUPT_ECOLI PhylomeDB P0A8H3 http://phylomedb.org/?seqid=P0A8H3 ProteinModelPortal P0A8H3 http://www.proteinmodelportal.org/query/uniprot/P0A8H3 PubMed 11790762 http://www.ncbi.nlm.nih.gov/pubmed/11790762 PubMed 1314093 http://www.ncbi.nlm.nih.gov/pubmed/1314093 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417512 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417512 RefSeq WP_001295627 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295627 STRING 511145.b3040 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3040&targetmode=cogs STRING COG0428 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0428&targetmode=cogs TCDB 2.A.5.5 http://www.tcdb.org/search/result.php?tc=2.A.5.5 UniProtKB ZUPT_ECOLI http://www.uniprot.org/uniprot/ZUPT_ECOLI UniProtKB-AC P0A8H3 http://www.uniprot.org/uniprot/P0A8H3 charge swissprot:ZUPT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ZUPT_ECOLI eggNOG COG0428 http://eggnogapi.embl.de/nog_data/html/tree/COG0428 eggNOG ENOG4105DUN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DUN epestfind swissprot:ZUPT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ZUPT_ECOLI garnier swissprot:ZUPT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ZUPT_ECOLI helixturnhelix swissprot:ZUPT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ZUPT_ECOLI hmoment swissprot:ZUPT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ZUPT_ECOLI iep swissprot:ZUPT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ZUPT_ECOLI inforesidue swissprot:ZUPT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ZUPT_ECOLI octanol swissprot:ZUPT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ZUPT_ECOLI pepcoil swissprot:ZUPT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ZUPT_ECOLI pepdigest swissprot:ZUPT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ZUPT_ECOLI pepinfo swissprot:ZUPT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ZUPT_ECOLI pepnet swissprot:ZUPT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ZUPT_ECOLI pepstats swissprot:ZUPT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ZUPT_ECOLI pepwheel swissprot:ZUPT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ZUPT_ECOLI pepwindow swissprot:ZUPT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ZUPT_ECOLI sigcleave swissprot:ZUPT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ZUPT_ECOLI ## Database ID URL or Descriptions # BioGrid 4259557 113 # EcoGene EG14294 ynaJ # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR019685 DUF2534 # Organism YNAJ_ECOLI Escherichia coli (strain K12) # PATRIC 32117940 VBIEscCol129921_1390 # PIR G64882 G64882 # Pfam PF10749 DUF2534 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNAJ_ECOLI Uncharacterized protein YnaJ # RefSeq NP_415848 NC_000913.3 # RefSeq WP_000605090 NZ_LN832404.1 # SUBCELLULAR LOCATION YNAJ_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # eggNOG ENOG4105S5I Bacteria # eggNOG ENOG41120VM LUCA BLAST swissprot:YNAJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNAJ_ECOLI BioCyc ECOL316407:JW1326-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1326-MONOMER BioCyc EcoCyc:G6668-MONOMER http://biocyc.org/getid?id=EcoCyc:G6668-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4042 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4042 EcoGene EG14294 http://www.ecogene.org/geneInfo.php?eg_id=EG14294 EnsemblBacteria AAC74414 http://www.ensemblgenomes.org/id/AAC74414 EnsemblBacteria AAC74414 http://www.ensemblgenomes.org/id/AAC74414 EnsemblBacteria BAE76403 http://www.ensemblgenomes.org/id/BAE76403 EnsemblBacteria BAE76403 http://www.ensemblgenomes.org/id/BAE76403 EnsemblBacteria BAE76403 http://www.ensemblgenomes.org/id/BAE76403 EnsemblBacteria b1332 http://www.ensemblgenomes.org/id/b1332 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 945901 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945901 HOGENOM HOG000120120 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120120&db=HOGENOM6 InterPro IPR019685 http://www.ebi.ac.uk/interpro/entry/IPR019685 KEGG_Gene ecj:JW1326 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1326 KEGG_Gene eco:b1332 http://www.genome.jp/dbget-bin/www_bget?eco:b1332 OMA QSAMICV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QSAMICV PSORT swissprot:YNAJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNAJ_ECOLI PSORT-B swissprot:YNAJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNAJ_ECOLI PSORT2 swissprot:YNAJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNAJ_ECOLI Pfam PF10749 http://pfam.xfam.org/family/PF10749 Phobius swissprot:YNAJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNAJ_ECOLI ProteinModelPortal P64445 http://www.proteinmodelportal.org/query/uniprot/P64445 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415848 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415848 RefSeq WP_000605090 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000605090 STRING 511145.b1332 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1332&targetmode=cogs UniProtKB YNAJ_ECOLI http://www.uniprot.org/uniprot/YNAJ_ECOLI UniProtKB-AC P64445 http://www.uniprot.org/uniprot/P64445 charge swissprot:YNAJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNAJ_ECOLI eggNOG ENOG4105S5I http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105S5I eggNOG ENOG41120VM http://eggnogapi.embl.de/nog_data/html/tree/ENOG41120VM epestfind swissprot:YNAJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNAJ_ECOLI garnier swissprot:YNAJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNAJ_ECOLI helixturnhelix swissprot:YNAJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNAJ_ECOLI hmoment swissprot:YNAJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNAJ_ECOLI iep swissprot:YNAJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNAJ_ECOLI inforesidue swissprot:YNAJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNAJ_ECOLI octanol swissprot:YNAJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNAJ_ECOLI pepcoil swissprot:YNAJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNAJ_ECOLI pepdigest swissprot:YNAJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNAJ_ECOLI pepinfo swissprot:YNAJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNAJ_ECOLI pepnet swissprot:YNAJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNAJ_ECOLI pepstats swissprot:YNAJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNAJ_ECOLI pepwheel swissprot:YNAJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNAJ_ECOLI pepwindow swissprot:YNAJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNAJ_ECOLI sigcleave swissprot:YNAJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNAJ_ECOLI ## Database ID URL or Descriptions # EcoGene EG14178 yffQ # Organism YFFQ_ECOLI Escherichia coli (strain K12) # PATRIC 32120277 VBIEscCol129921_2541 # PIR G65019 G65019 # Proteomes UP000000625 Chromosome # RecName YFFQ_ECOLI Uncharacterized protein YffQ # RefSeq NP_416943 NC_000913.3 # RefSeq WP_000770705 NZ_CP014272.1 BLAST swissprot:YFFQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFFQ_ECOLI BioCyc EcoCyc:G7278-MONOMER http://biocyc.org/getid?id=EcoCyc:G7278-MONOMER DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3930 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3930 EcoGene EG14178 http://www.ecogene.org/geneInfo.php?eg_id=EG14178 EnsemblBacteria AAC75501 http://www.ensemblgenomes.org/id/AAC75501 EnsemblBacteria AAC75501 http://www.ensemblgenomes.org/id/AAC75501 EnsemblBacteria b2448 http://www.ensemblgenomes.org/id/b2448 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946927 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946927 HOGENOM HOG000054852 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000054852&db=HOGENOM6 KEGG_Gene eco:b2448 http://www.genome.jp/dbget-bin/www_bget?eco:b2448 PSORT swissprot:YFFQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFFQ_ECOLI PSORT-B swissprot:YFFQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFFQ_ECOLI PSORT2 swissprot:YFFQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFFQ_ECOLI Phobius swissprot:YFFQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFFQ_ECOLI ProteinModelPortal P76548 http://www.proteinmodelportal.org/query/uniprot/P76548 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416943 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416943 RefSeq WP_000770705 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000770705 STRING 511145.b2448 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2448&targetmode=cogs UniProtKB YFFQ_ECOLI http://www.uniprot.org/uniprot/YFFQ_ECOLI UniProtKB-AC P76548 http://www.uniprot.org/uniprot/P76548 charge swissprot:YFFQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFFQ_ECOLI epestfind swissprot:YFFQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFFQ_ECOLI garnier swissprot:YFFQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFFQ_ECOLI helixturnhelix swissprot:YFFQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFFQ_ECOLI hmoment swissprot:YFFQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFFQ_ECOLI iep swissprot:YFFQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFFQ_ECOLI inforesidue swissprot:YFFQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFFQ_ECOLI octanol swissprot:YFFQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFFQ_ECOLI pepcoil swissprot:YFFQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFFQ_ECOLI pepdigest swissprot:YFFQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFFQ_ECOLI pepinfo swissprot:YFFQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFFQ_ECOLI pepnet swissprot:YFFQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFFQ_ECOLI pepstats swissprot:YFFQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFFQ_ECOLI pepwheel swissprot:YFFQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFFQ_ECOLI pepwindow swissprot:YFFQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFFQ_ECOLI sigcleave swissprot:YFFQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFFQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4259968 17 # COFACTOR YBHJ_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000250}; Note=Binds 1 [4Fe-4S] cluster per subunit. {ECO 0000250}; # EcoGene EG13666 ybhJ # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051536 iron-sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0006979 response to oxidative stress; IMP:EcoCyc. # GO_process GO:0008152 metabolic process; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # Gene3D 3.20.19.10 -; 1. # Gene3D 3.30.499.10 -; 3. # Gene3D 3.40.1060.10 -; 1. # InterPro IPR000573 AconitaseA/IPMdHydase_ssu_swvl # InterPro IPR001030 Acoase/IPM_deHydtase_lsu_aba # InterPro IPR015928 Aconitase/3IPM_dehydase_swvl # InterPro IPR015931 Acnase/IPM_dHydase_lsu_aba_1/3 # InterPro IPR015932 Aconitase/IPMdHydase_lsu_aba_2 # InterPro IPR015937 Acoase/IPM_deHydtase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00020 Citrate cycle (TCA cycle) # KEGG_Pathway ko00300 Lysine biosynthesis # KEGG_Pathway ko00630 Glyoxylate and dicarboxylate metabolism # KEGG_Pathway ko00720 Carbon fixation pathways in prokaryotes # Organism YBHJ_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11670 PTHR11670; 3 # PATRIC 32116743 VBIEscCol129921_0797 # PIR C64813 C64813 # PRINTS PR00415 ACONITASE # Pfam PF00330 Aconitase # Pfam PF00694 Aconitase_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBHJ_ECOLI Uncharacterized protein YbhJ # RefSeq NP_415292 NC_000913.3 # RefSeq WP_000593938 NZ_LN832404.1 # SIMILARITY Belongs to the aconitase/IPM isomerase family. {ECO 0000305}. # SUPFAM SSF52016 SSF52016 # SUPFAM SSF53732 SSF53732 # eggNOG COG1048 LUCA # eggNOG ENOG4107QM5 Bacteria BLAST swissprot:YBHJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBHJ_ECOLI BioCyc ECOL316407:JW5103-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5103-MONOMER BioCyc EcoCyc:G6401-MONOMER http://biocyc.org/getid?id=EcoCyc:G6401-MONOMER COG COG1048 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1048 DIP DIP-11413N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11413N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3430 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3430 EcoGene EG13666 http://www.ecogene.org/geneInfo.php?eg_id=EG13666 EnsemblBacteria AAC73858 http://www.ensemblgenomes.org/id/AAC73858 EnsemblBacteria AAC73858 http://www.ensemblgenomes.org/id/AAC73858 EnsemblBacteria BAA35435 http://www.ensemblgenomes.org/id/BAA35435 EnsemblBacteria BAA35435 http://www.ensemblgenomes.org/id/BAA35435 EnsemblBacteria BAA35435 http://www.ensemblgenomes.org/id/BAA35435 EnsemblBacteria b0771 http://www.ensemblgenomes.org/id/b0771 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051536 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051536 GO_process GO:0006979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979 GO_process GO:0008152 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008152 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.20.19.10 http://www.cathdb.info/version/latest/superfamily/3.20.19.10 Gene3D 3.30.499.10 http://www.cathdb.info/version/latest/superfamily/3.30.499.10 Gene3D 3.40.1060.10 http://www.cathdb.info/version/latest/superfamily/3.40.1060.10 GeneID 945380 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945380 HOGENOM HOG000118046 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118046&db=HOGENOM6 InParanoid P75764 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75764 InterPro IPR000573 http://www.ebi.ac.uk/interpro/entry/IPR000573 InterPro IPR001030 http://www.ebi.ac.uk/interpro/entry/IPR001030 InterPro IPR015928 http://www.ebi.ac.uk/interpro/entry/IPR015928 InterPro IPR015931 http://www.ebi.ac.uk/interpro/entry/IPR015931 InterPro IPR015932 http://www.ebi.ac.uk/interpro/entry/IPR015932 InterPro IPR015937 http://www.ebi.ac.uk/interpro/entry/IPR015937 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5103 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5103 KEGG_Gene eco:b0771 http://www.genome.jp/dbget-bin/www_bget?eco:b0771 KEGG_Orthology KO:K01681 http://www.genome.jp/dbget-bin/www_bget?KO:K01681 KEGG_Pathway ko00020 http://www.genome.jp/kegg-bin/show_pathway?ko00020 KEGG_Pathway ko00300 http://www.genome.jp/kegg-bin/show_pathway?ko00300 KEGG_Pathway ko00630 http://www.genome.jp/kegg-bin/show_pathway?ko00630 KEGG_Pathway ko00720 http://www.genome.jp/kegg-bin/show_pathway?ko00720 KEGG_Reaction rn:R01324 http://www.genome.jp/dbget-bin/www_bget?rn:R01324 KEGG_Reaction rn:R01325 http://www.genome.jp/dbget-bin/www_bget?rn:R01325 KEGG_Reaction rn:R01900 http://www.genome.jp/dbget-bin/www_bget?rn:R01900 OMA KPGNGQM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KPGNGQM PANTHER PTHR11670 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11670 PRINTS PR00415 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00415 PSORT swissprot:YBHJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBHJ_ECOLI PSORT-B swissprot:YBHJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBHJ_ECOLI PSORT2 swissprot:YBHJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBHJ_ECOLI Pfam PF00330 http://pfam.xfam.org/family/PF00330 Pfam PF00694 http://pfam.xfam.org/family/PF00694 Phobius swissprot:YBHJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBHJ_ECOLI PhylomeDB P75764 http://phylomedb.org/?seqid=P75764 ProteinModelPortal P75764 http://www.proteinmodelportal.org/query/uniprot/P75764 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415292 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415292 RefSeq WP_000593938 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000593938 STRING 511145.b0771 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0771&targetmode=cogs STRING COG1048 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1048&targetmode=cogs SUPFAM SSF52016 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52016 SUPFAM SSF53732 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53732 UniProtKB YBHJ_ECOLI http://www.uniprot.org/uniprot/YBHJ_ECOLI UniProtKB-AC P75764 http://www.uniprot.org/uniprot/P75764 charge swissprot:YBHJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBHJ_ECOLI eggNOG COG1048 http://eggnogapi.embl.de/nog_data/html/tree/COG1048 eggNOG ENOG4107QM5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QM5 epestfind swissprot:YBHJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBHJ_ECOLI garnier swissprot:YBHJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBHJ_ECOLI helixturnhelix swissprot:YBHJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBHJ_ECOLI hmoment swissprot:YBHJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBHJ_ECOLI iep swissprot:YBHJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBHJ_ECOLI inforesidue swissprot:YBHJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBHJ_ECOLI octanol swissprot:YBHJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBHJ_ECOLI pepcoil swissprot:YBHJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBHJ_ECOLI pepdigest swissprot:YBHJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBHJ_ECOLI pepinfo swissprot:YBHJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBHJ_ECOLI pepnet swissprot:YBHJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBHJ_ECOLI pepstats swissprot:YBHJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBHJ_ECOLI pepwheel swissprot:YBHJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBHJ_ECOLI pepwindow swissprot:YBHJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBHJ_ECOLI sigcleave swissprot:YBHJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBHJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4263229 49 # EcoGene EG13911 ycjN # FUNCTION YCJN_ECOLI Probably part of the binding-protein-dependent transport system YcjNOP. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_function GO:0005215 transporter activity; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # InterPro IPR006059 SBP_1_dom # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00207 Putative multiple sugar transport system # KEGG_Brite ko02000 Transporters # Organism YCJN_ECOLI Escherichia coli (strain K12) # PATRIC 32117892 VBIEscCol129921_1366 # PIR A64880 A64880 # Pfam PF01547 SBP_bac_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCJN_ECOLI Putative ABC transporter periplasmic-binding protein YcjN # RefSeq NP_415826 NC_000913.3 # RefSeq WP_000597466 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial solute-binding protein 1 family. {ECO 0000305}. # SUBCELLULAR LOCATION YCJN_ECOLI Periplasm {ECO 0000305}. # TCDB 3.A.1.1.46 the atp-binding cassette (abc) superfamily # eggNOG COG1653 LUCA # eggNOG ENOG4105WEM Bacteria BLAST swissprot:YCJN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCJN_ECOLI BioCyc ECOL316407:JW1303-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1303-MONOMER BioCyc EcoCyc:YCJN-MONOMER http://biocyc.org/getid?id=EcoCyc:YCJN-MONOMER COG COG1653 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1653 COG COG2182 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2182 DIP DIP-11605N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11605N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3670 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3670 EcoGene EG13911 http://www.ecogene.org/geneInfo.php?eg_id=EG13911 EnsemblBacteria AAC74392 http://www.ensemblgenomes.org/id/AAC74392 EnsemblBacteria AAC74392 http://www.ensemblgenomes.org/id/AAC74392 EnsemblBacteria BAE76398 http://www.ensemblgenomes.org/id/BAE76398 EnsemblBacteria BAE76398 http://www.ensemblgenomes.org/id/BAE76398 EnsemblBacteria BAE76398 http://www.ensemblgenomes.org/id/BAE76398 EnsemblBacteria b1310 http://www.ensemblgenomes.org/id/b1310 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GeneID 945696 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945696 HOGENOM HOG000089522 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000089522&db=HOGENOM6 InParanoid P76042 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76042 IntAct P76042 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76042* InterPro IPR006059 http://www.ebi.ac.uk/interpro/entry/IPR006059 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1303 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1303 KEGG_Gene eco:b1310 http://www.genome.jp/dbget-bin/www_bget?eco:b1310 KEGG_Orthology KO:K02027 http://www.genome.jp/dbget-bin/www_bget?KO:K02027 OMA NKTHVSI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NKTHVSI PSORT swissprot:YCJN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCJN_ECOLI PSORT-B swissprot:YCJN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCJN_ECOLI PSORT2 swissprot:YCJN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCJN_ECOLI Pfam PF01547 http://pfam.xfam.org/family/PF01547 Phobius swissprot:YCJN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCJN_ECOLI PhylomeDB P76042 http://phylomedb.org/?seqid=P76042 ProteinModelPortal P76042 http://www.proteinmodelportal.org/query/uniprot/P76042 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415826 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415826 RefSeq WP_000597466 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000597466 STRING 511145.b1310 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1310&targetmode=cogs STRING COG1653 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1653&targetmode=cogs STRING COG2182 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2182&targetmode=cogs TCDB 3.A.1.1.46 http://www.tcdb.org/search/result.php?tc=3.A.1.1.46 UniProtKB YCJN_ECOLI http://www.uniprot.org/uniprot/YCJN_ECOLI UniProtKB-AC P76042 http://www.uniprot.org/uniprot/P76042 charge swissprot:YCJN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCJN_ECOLI eggNOG COG1653 http://eggnogapi.embl.de/nog_data/html/tree/COG1653 eggNOG ENOG4105WEM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105WEM epestfind swissprot:YCJN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCJN_ECOLI garnier swissprot:YCJN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCJN_ECOLI helixturnhelix swissprot:YCJN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCJN_ECOLI hmoment swissprot:YCJN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCJN_ECOLI iep swissprot:YCJN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCJN_ECOLI inforesidue swissprot:YCJN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCJN_ECOLI octanol swissprot:YCJN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCJN_ECOLI pepcoil swissprot:YCJN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCJN_ECOLI pepdigest swissprot:YCJN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCJN_ECOLI pepinfo swissprot:YCJN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCJN_ECOLI pepnet swissprot:YCJN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCJN_ECOLI pepstats swissprot:YCJN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCJN_ECOLI pepwheel swissprot:YCJN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCJN_ECOLI pepwindow swissprot:YCJN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCJN_ECOLI sigcleave swissprot:YCJN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCJN_ECOLI ## Database ID URL or Descriptions # BioGrid 4260166 14 # EcoGene EG12157 ydaF # InterPro IPR009821 DUF1391 # Organism YDAF_ECOLI Escherichia coli (strain K12) # PATRIC 48662005 VBIEscCol107702_1366 # PIR T09180 T09180 # Pfam PF07151 DUF1391 # ProDom PD019047 DUF1391 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDAF_ECOLI Uncharacterized protein YdaF # RefSeq NP_415872 NC_000913.3 # RefSeq WP_001169151 NZ_CP014272.1 # SIMILARITY To E.coli YdfA. {ECO 0000305}. BLAST swissprot:YDAF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDAF_ECOLI BioCyc ECOL316407:JW1349-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1349-MONOMER BioCyc EcoCyc:MONOMER0-2670 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2670 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2077 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2077 EcoGene EG12157 http://www.ecogene.org/geneInfo.php?eg_id=EG12157 EnsemblBacteria AAC74436 http://www.ensemblgenomes.org/id/AAC74436 EnsemblBacteria AAC74436 http://www.ensemblgenomes.org/id/AAC74436 EnsemblBacteria BAA14957 http://www.ensemblgenomes.org/id/BAA14957 EnsemblBacteria BAA14957 http://www.ensemblgenomes.org/id/BAA14957 EnsemblBacteria BAA14957 http://www.ensemblgenomes.org/id/BAA14957 EnsemblBacteria b4527 http://www.ensemblgenomes.org/id/b4527 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945911 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945911 HOGENOM HOG000009419 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009419&db=HOGENOM6 InterPro IPR009821 http://www.ebi.ac.uk/interpro/entry/IPR009821 KEGG_Gene ecj:JW1349 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1349 KEGG_Gene eco:b4527 http://www.genome.jp/dbget-bin/www_bget?eco:b4527 OMA NESIVCG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NESIVCG PSORT swissprot:YDAF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDAF_ECOLI PSORT-B swissprot:YDAF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDAF_ECOLI PSORT2 swissprot:YDAF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDAF_ECOLI Pfam PF07151 http://pfam.xfam.org/family/PF07151 Phobius swissprot:YDAF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDAF_ECOLI ProteinModelPortal P0ACW0 http://www.proteinmodelportal.org/query/uniprot/P0ACW0 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415872 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415872 RefSeq WP_001169151 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001169151 STRING 511145.b4527 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4527&targetmode=cogs UniProtKB YDAF_ECOLI http://www.uniprot.org/uniprot/YDAF_ECOLI UniProtKB-AC P0ACW0 http://www.uniprot.org/uniprot/P0ACW0 charge swissprot:YDAF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDAF_ECOLI epestfind swissprot:YDAF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDAF_ECOLI garnier swissprot:YDAF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDAF_ECOLI helixturnhelix swissprot:YDAF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDAF_ECOLI hmoment swissprot:YDAF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDAF_ECOLI iep swissprot:YDAF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDAF_ECOLI inforesidue swissprot:YDAF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDAF_ECOLI octanol swissprot:YDAF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDAF_ECOLI pepcoil swissprot:YDAF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDAF_ECOLI pepdigest swissprot:YDAF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDAF_ECOLI pepinfo swissprot:YDAF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDAF_ECOLI pepnet swissprot:YDAF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDAF_ECOLI pepstats swissprot:YDAF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDAF_ECOLI pepwheel swissprot:YDAF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDAF_ECOLI pepwindow swissprot:YDAF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDAF_ECOLI sigcleave swissprot:YDAF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDAF_ECOLI ## Database ID URL or Descriptions # AltName GLXR_ECOLI Tartronate semialdehyde reductase # BioGrid 4262821 13 # CATALYTIC ACTIVITY GLXR_ECOLI D-glycerate + NAD(P)(+) = 2-hydroxy-3- oxopropanoate + NAD(P)H. # EcoGene EG13265 glxR # GO_function GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity; IEA:InterPro. # GO_function GO:0008679 2-hydroxy-3-oxopropionate reductase activity; IDA:EcoCyc. # GO_function GO:0051287 NAD binding; IEA:InterPro. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0009436 glyoxylate catabolic process; IMP:EcoCyc. # GO_process GO:0009442 allantoin assimilation pathway; IEP:EcoCyc. # GO_process GO:0046296 glycolate catabolic process; IEA:UniProtKB-UniPathway. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.1040.10 -; 1. # Gene3D 3.40.50.720 -; 1. # INDUCTION GLXR_ECOLI By glyoxylate. # IntAct P77161 9 # InterPro IPR002204 3-OH-isobutyrate_DH-rel_CS # InterPro IPR006115 6PGDH_NADP-bd # InterPro IPR006398 Tartro_sem_red # InterPro IPR008927 6-PGluconate_DH_C-like # InterPro IPR013328 6PGD_dom_2 # InterPro IPR015815 HIBADH-related # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR029154 NADP-bd # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00630 Glyoxylate and dicarboxylate metabolism # Organism GLXR_ECOLI Escherichia coli (strain K12) # PATHWAY Organic acid metabolism; glycolate degradation; 3- phospho-D-glycerate from glycolate step 3/4. # PATRIC 32116177 VBIEscCol129921_0530 # PIR D64782 D64782 # PIRSF PIRSF000103 HIBADH # PROSITE PS00895 3_HYDROXYISOBUT_DH # Pfam PF03446 NAD_binding_2 # Pfam PF14833 NAD_binding_11 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLXR_ECOLI 2-hydroxy-3-oxopropionate reductase # RefSeq NP_415042 NC_000913.3 # RefSeq WP_000765839 NZ_LN832404.1 # SIMILARITY Belongs to the 3-hydroxyisobutyrate dehydrogenase family. {ECO 0000305}. # SUPFAM SSF48179 SSF48179 # SUPFAM SSF51735 SSF51735 # TIGRFAMs TIGR01505 tartro_sem_red # UniPathway UPA00864 UER00832 # eggNOG COG2084 LUCA # eggNOG ENOG4105CF3 Bacteria BLAST swissprot:GLXR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLXR_ECOLI BioCyc ECOL316407:JW0497-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0497-MONOMER BioCyc EcoCyc:G6278-MONOMER http://biocyc.org/getid?id=EcoCyc:G6278-MONOMER BioCyc MetaCyc:G6278-MONOMER http://biocyc.org/getid?id=MetaCyc:G6278-MONOMER COG COG2084 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2084 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.60 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.60 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL U89279 http://www.ebi.ac.uk/ena/data/view/U89279 ENZYME 1.1.1.60 http://enzyme.expasy.org/EC/1.1.1.60 EchoBASE EB3052 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3052 EcoGene EG13265 http://www.ecogene.org/geneInfo.php?eg_id=EG13265 EnsemblBacteria AAC73611 http://www.ensemblgenomes.org/id/AAC73611 EnsemblBacteria AAC73611 http://www.ensemblgenomes.org/id/AAC73611 EnsemblBacteria BAE76287 http://www.ensemblgenomes.org/id/BAE76287 EnsemblBacteria BAE76287 http://www.ensemblgenomes.org/id/BAE76287 EnsemblBacteria BAE76287 http://www.ensemblgenomes.org/id/BAE76287 EnsemblBacteria b0509 http://www.ensemblgenomes.org/id/b0509 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004616 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004616 GO_function GO:0008679 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008679 GO_function GO:0051287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051287 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0009436 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009436 GO_process GO:0009442 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009442 GO_process GO:0046296 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046296 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.1040.10 http://www.cathdb.info/version/latest/superfamily/1.10.1040.10 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 945146 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945146 HOGENOM HOG000219608 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219608&db=HOGENOM6 InParanoid P77161 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77161 IntAct P77161 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77161* IntEnz 1.1.1.60 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.60 InterPro IPR002204 http://www.ebi.ac.uk/interpro/entry/IPR002204 InterPro IPR006115 http://www.ebi.ac.uk/interpro/entry/IPR006115 InterPro IPR006398 http://www.ebi.ac.uk/interpro/entry/IPR006398 InterPro IPR008927 http://www.ebi.ac.uk/interpro/entry/IPR008927 InterPro IPR013328 http://www.ebi.ac.uk/interpro/entry/IPR013328 InterPro IPR015815 http://www.ebi.ac.uk/interpro/entry/IPR015815 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR029154 http://www.ebi.ac.uk/interpro/entry/IPR029154 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0497 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0497 KEGG_Gene eco:b0509 http://www.genome.jp/dbget-bin/www_bget?eco:b0509 KEGG_Orthology KO:K00042 http://www.genome.jp/dbget-bin/www_bget?KO:K00042 KEGG_Pathway ko00630 http://www.genome.jp/kegg-bin/show_pathway?ko00630 KEGG_Reaction rn:R01745 http://www.genome.jp/dbget-bin/www_bget?rn:R01745 KEGG_Reaction rn:R01747 http://www.genome.jp/dbget-bin/www_bget?rn:R01747 OMA MIVGMTI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MIVGMTI PROSITE PS00895 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00895 PSORT swissprot:GLXR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLXR_ECOLI PSORT-B swissprot:GLXR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLXR_ECOLI PSORT2 swissprot:GLXR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLXR_ECOLI Pfam PF03446 http://pfam.xfam.org/family/PF03446 Pfam PF14833 http://pfam.xfam.org/family/PF14833 Phobius swissprot:GLXR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLXR_ECOLI PhylomeDB P77161 http://phylomedb.org/?seqid=P77161 ProteinModelPortal P77161 http://www.proteinmodelportal.org/query/uniprot/P77161 PubMed 10601204 http://www.ncbi.nlm.nih.gov/pubmed/10601204 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415042 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415042 RefSeq WP_000765839 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000765839 SMR P77161 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77161 STRING 511145.b0509 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0509&targetmode=cogs STRING COG2084 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2084&targetmode=cogs SUPFAM SSF48179 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48179 SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 TIGRFAMs TIGR01505 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01505 UniProtKB GLXR_ECOLI http://www.uniprot.org/uniprot/GLXR_ECOLI UniProtKB-AC P77161 http://www.uniprot.org/uniprot/P77161 charge swissprot:GLXR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLXR_ECOLI eggNOG COG2084 http://eggnogapi.embl.de/nog_data/html/tree/COG2084 eggNOG ENOG4105CF3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CF3 epestfind swissprot:GLXR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLXR_ECOLI garnier swissprot:GLXR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLXR_ECOLI helixturnhelix swissprot:GLXR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLXR_ECOLI hmoment swissprot:GLXR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLXR_ECOLI iep swissprot:GLXR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLXR_ECOLI inforesidue swissprot:GLXR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLXR_ECOLI octanol swissprot:GLXR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLXR_ECOLI pepcoil swissprot:GLXR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLXR_ECOLI pepdigest swissprot:GLXR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLXR_ECOLI pepinfo swissprot:GLXR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLXR_ECOLI pepnet swissprot:GLXR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLXR_ECOLI pepstats swissprot:GLXR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLXR_ECOLI pepwheel swissprot:GLXR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLXR_ECOLI pepwindow swissprot:GLXR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLXR_ECOLI sigcleave swissprot:GLXR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLXR_ECOLI ## Database ID URL or Descriptions # AltName YGHE_ECOLI Putative general secretion pathway L-type protein YghE # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG12989 yghE # FUNCTION YGHE_ECOLI Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (Potentail). # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0009276 Gram-negative-bacterium-type cell wall; IEA:InterPro. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0008565 protein transporter activity; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005618 cell wall # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0008565 protein transporter activity # InterPro IPR007812 T2SS_protein-L # InterPro IPR025691 GspL_pp_dom # Organism YGHE_ECOLI Escherichia coli (strain K12) # PIR G65082 G65082 # Pfam PF12693 GspL_C # Proteomes UP000000625 Chromosome # RecName YGHE_ECOLI Putative type II secretion system L-type protein YghE # RefSeq WP_001393563 NZ_LN832404.1 # SIMILARITY Belongs to the GSP L family. {ECO 0000305}. # SUBCELLULAR LOCATION YGHE_ECOLI Cell inner membrane {ECO 0000305}. # TIGRFAMs TIGR01709 typeII_sec_gspL BLAST swissprot:YGHE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGHE_ECOLI BioCyc EcoCyc:G7536-MONOMER http://biocyc.org/getid?id=EcoCyc:G7536-MONOMER DIP DIP-12203N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12203N DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2813 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2813 EcoGene EG12989 http://www.ecogene.org/geneInfo.php?eg_id=EG12989 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0009276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009276 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005618 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 HOGENOM HOG000124870 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000124870&db=HOGENOM6 IntAct Q46833 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46833* InterPro IPR007812 http://www.ebi.ac.uk/interpro/entry/IPR007812 InterPro IPR025691 http://www.ebi.ac.uk/interpro/entry/IPR025691 MINT MINT-1231396 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1231396 OMA ICHIDEC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ICHIDEC PSORT swissprot:YGHE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGHE_ECOLI PSORT-B swissprot:YGHE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGHE_ECOLI PSORT2 swissprot:YGHE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGHE_ECOLI Pfam PF12693 http://pfam.xfam.org/family/PF12693 Phobius swissprot:YGHE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGHE_ECOLI ProteinModelPortal Q46833 http://www.proteinmodelportal.org/query/uniprot/Q46833 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001393563 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001393563 TIGRFAMs TIGR01709 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01709 UniProtKB YGHE_ECOLI http://www.uniprot.org/uniprot/YGHE_ECOLI UniProtKB-AC Q46833 http://www.uniprot.org/uniprot/Q46833 charge swissprot:YGHE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGHE_ECOLI epestfind swissprot:YGHE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGHE_ECOLI garnier swissprot:YGHE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGHE_ECOLI helixturnhelix swissprot:YGHE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGHE_ECOLI hmoment swissprot:YGHE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGHE_ECOLI iep swissprot:YGHE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGHE_ECOLI inforesidue swissprot:YGHE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGHE_ECOLI octanol swissprot:YGHE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGHE_ECOLI pepcoil swissprot:YGHE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGHE_ECOLI pepdigest swissprot:YGHE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGHE_ECOLI pepinfo swissprot:YGHE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGHE_ECOLI pepnet swissprot:YGHE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGHE_ECOLI pepstats swissprot:YGHE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGHE_ECOLI pepwheel swissprot:YGHE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGHE_ECOLI pepwindow swissprot:YGHE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGHE_ECOLI sigcleave swissprot:YGHE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGHE_ECOLI ## Database ID URL or Descriptions # BioGrid 4261976 162 # EcoGene EG11686 yicJ # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015293 symporter activity; IEA:UniProtKB-KW. # GO_process GO:0006814 sodium ion transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR001927 Na/Gal_symport # InterPro IPR018043 Na/Gal_symport_CS # InterPro IPR020846 MFS_dom # Organism YICJ_ECOLI Escherichia coli (strain K12) # PATRIC 32122801 VBIEscCol129921_3777 # PROSITE PS00872 NA_GALACTOSIDE_SYMP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YICJ_ECOLI Inner membrane symporter YicJ # RefSeq NP_418114 NC_000913.3 # RefSeq WP_000834439 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA62010.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the sodium:galactoside symporter (TC 2.A.2) family. {ECO 0000305}. # SUBCELLULAR LOCATION YICJ_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.2.3:the glycoside-pentoside-hexuronide (gph) cation symporter family # TIGRFAMs TIGR00792 gph # eggNOG COG2211 LUCA # eggNOG ENOG4105CT4 Bacteria BLAST swissprot:YICJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YICJ_ECOLI BioCyc ECOL316407:JW5939-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5939-MONOMER BioCyc EcoCyc:YICJ-MONOMER http://biocyc.org/getid?id=EcoCyc:YICJ-MONOMER COG COG2211 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2211 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1637 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1637 EcoGene EG11686 http://www.ecogene.org/geneInfo.php?eg_id=EG11686 EnsemblBacteria AAC76681 http://www.ensemblgenomes.org/id/AAC76681 EnsemblBacteria AAC76681 http://www.ensemblgenomes.org/id/AAC76681 EnsemblBacteria BAE77636 http://www.ensemblgenomes.org/id/BAE77636 EnsemblBacteria BAE77636 http://www.ensemblgenomes.org/id/BAE77636 EnsemblBacteria BAE77636 http://www.ensemblgenomes.org/id/BAE77636 EnsemblBacteria b3657 http://www.ensemblgenomes.org/id/b3657 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015293 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293 GO_process GO:0006814 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948168 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948168 HOGENOM HOG000222022 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000222022&db=HOGENOM6 InParanoid P31435 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31435 InterPro IPR001927 http://www.ebi.ac.uk/interpro/entry/IPR001927 InterPro IPR018043 http://www.ebi.ac.uk/interpro/entry/IPR018043 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Gene ecj:JW5939 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5939 KEGG_Gene eco:b3657 http://www.genome.jp/dbget-bin/www_bget?eco:b3657 KEGG_Orthology KO:K03292 http://www.genome.jp/dbget-bin/www_bget?KO:K03292 OMA WWTNAIL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WWTNAIL PROSITE PS00872 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00872 PSORT swissprot:YICJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YICJ_ECOLI PSORT-B swissprot:YICJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YICJ_ECOLI PSORT2 swissprot:YICJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YICJ_ECOLI Phobius swissprot:YICJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YICJ_ECOLI PhylomeDB P31435 http://phylomedb.org/?seqid=P31435 ProteinModelPortal P31435 http://www.proteinmodelportal.org/query/uniprot/P31435 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418114 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418114 RefSeq WP_000834439 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000834439 STRING 511145.b3657 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3657&targetmode=cogs STRING COG2211 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2211&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.2.3 http://www.tcdb.org/search/result.php?tc=2.A.2.3 TIGRFAMs TIGR00792 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00792 UniProtKB YICJ_ECOLI http://www.uniprot.org/uniprot/YICJ_ECOLI UniProtKB-AC P31435 http://www.uniprot.org/uniprot/P31435 charge swissprot:YICJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YICJ_ECOLI eggNOG COG2211 http://eggnogapi.embl.de/nog_data/html/tree/COG2211 eggNOG ENOG4105CT4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CT4 epestfind swissprot:YICJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YICJ_ECOLI garnier swissprot:YICJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YICJ_ECOLI helixturnhelix swissprot:YICJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YICJ_ECOLI hmoment swissprot:YICJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YICJ_ECOLI iep swissprot:YICJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YICJ_ECOLI inforesidue swissprot:YICJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YICJ_ECOLI octanol swissprot:YICJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YICJ_ECOLI pepcoil swissprot:YICJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YICJ_ECOLI pepdigest swissprot:YICJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YICJ_ECOLI pepinfo swissprot:YICJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YICJ_ECOLI pepnet swissprot:YICJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YICJ_ECOLI pepstats swissprot:YICJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YICJ_ECOLI pepwheel swissprot:YICJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YICJ_ECOLI pepwindow swissprot:YICJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YICJ_ECOLI sigcleave swissprot:YICJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YICJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4262081 282 # EcoGene EG14287 ycaR # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # HAMAP MF_01187 UPF0434 # IntAct P0AAZ7 2 # InterPro IPR005651 UPF0434/Trm112 # Organism YCAR_ECOLI Escherichia coli (strain K12) # PATRIC 32117047 VBIEscCol129921_0948 # PIR D64831 D64831 # Pfam PF03966 Trm112p # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCAR_ECOLI UPF0434 protein YcaR # RefSeq NP_415437 NC_000913.3 # RefSeq WP_000350058 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0434 family. {ECO 0000305}. # eggNOG COG2835 LUCA # eggNOG ENOG4105W49 Bacteria BLAST swissprot:YCAR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCAR_ECOLI BioCyc ECOL316407:JW0900-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0900-MONOMER BioCyc EcoCyc:G6472-MONOMER http://biocyc.org/getid?id=EcoCyc:G6472-MONOMER COG COG2835 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2835 DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4035 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4035 EcoGene EG14287 http://www.ecogene.org/geneInfo.php?eg_id=EG14287 EnsemblBacteria AAC74003 http://www.ensemblgenomes.org/id/AAC74003 EnsemblBacteria AAC74003 http://www.ensemblgenomes.org/id/AAC74003 EnsemblBacteria BAA35663 http://www.ensemblgenomes.org/id/BAA35663 EnsemblBacteria BAA35663 http://www.ensemblgenomes.org/id/BAA35663 EnsemblBacteria BAA35663 http://www.ensemblgenomes.org/id/BAA35663 EnsemblBacteria b0917 http://www.ensemblgenomes.org/id/b0917 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GeneID 945537 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945537 HAMAP MF_01187 http://hamap.expasy.org/unirule/MF_01187 HOGENOM HOG000227338 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000227338&db=HOGENOM6 InParanoid P0AAZ7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAZ7 IntAct P0AAZ7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAZ7* InterPro IPR005651 http://www.ebi.ac.uk/interpro/entry/IPR005651 KEGG_Gene ecj:JW0900 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0900 KEGG_Gene eco:b0917 http://www.genome.jp/dbget-bin/www_bget?eco:b0917 KEGG_Orthology KO:K09791 http://www.genome.jp/dbget-bin/www_bget?KO:K09791 OMA ELICHAD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ELICHAD PSORT swissprot:YCAR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCAR_ECOLI PSORT-B swissprot:YCAR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCAR_ECOLI PSORT2 swissprot:YCAR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCAR_ECOLI Pfam PF03966 http://pfam.xfam.org/family/PF03966 Phobius swissprot:YCAR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCAR_ECOLI PhylomeDB P0AAZ7 http://phylomedb.org/?seqid=P0AAZ7 ProteinModelPortal P0AAZ7 http://www.proteinmodelportal.org/query/uniprot/P0AAZ7 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415437 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415437 RefSeq WP_000350058 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000350058 SMR P0AAZ7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAZ7 STRING 511145.b0917 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0917&targetmode=cogs STRING COG2835 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2835&targetmode=cogs UniProtKB YCAR_ECOLI http://www.uniprot.org/uniprot/YCAR_ECOLI UniProtKB-AC P0AAZ7 http://www.uniprot.org/uniprot/P0AAZ7 charge swissprot:YCAR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCAR_ECOLI eggNOG COG2835 http://eggnogapi.embl.de/nog_data/html/tree/COG2835 eggNOG ENOG4105W49 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105W49 epestfind swissprot:YCAR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCAR_ECOLI garnier swissprot:YCAR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCAR_ECOLI helixturnhelix swissprot:YCAR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCAR_ECOLI hmoment swissprot:YCAR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCAR_ECOLI iep swissprot:YCAR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCAR_ECOLI inforesidue swissprot:YCAR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCAR_ECOLI octanol swissprot:YCAR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCAR_ECOLI pepcoil swissprot:YCAR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCAR_ECOLI pepdigest swissprot:YCAR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCAR_ECOLI pepinfo swissprot:YCAR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCAR_ECOLI pepnet swissprot:YCAR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCAR_ECOLI pepstats swissprot:YCAR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCAR_ECOLI pepwheel swissprot:YCAR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCAR_ECOLI pepwindow swissprot:YCAR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCAR_ECOLI sigcleave swissprot:YCAR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCAR_ECOLI ## Database ID URL or Descriptions # BioGrid 4260656 13 # EcoGene EG12842 ybjC # InterPro IPR010815 DUF1418 # Organism YBJC_ECOLI Escherichia coli (strain K12) # PATRIC 32116905 VBIEscCol129921_0878 # PIR B64823 B64823 # Pfam PF07214 DUF1418 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBJC_ECOLI Uncharacterized protein YbjC # RefSeq NP_415371 NC_000913.3 # RefSeq WP_001201560 NZ_LN832404.1 # eggNOG ENOG4105X20 Bacteria # eggNOG ENOG41125IT LUCA BLAST swissprot:YBJC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBJC_ECOLI BioCyc ECOL316407:JW0834-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0834-MONOMER BioCyc EcoCyc:EG12842-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12842-MONOMER DOI 10.1016/0378-1119(86)90003-X http://dx.doi.org/10.1016/0378-1119(86)90003-X DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M13449 http://www.ebi.ac.uk/ena/data/view/M13449 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18655 http://www.ebi.ac.uk/ena/data/view/U18655 EchoBASE EB2691 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2691 EcoGene EG12842 http://www.ecogene.org/geneInfo.php?eg_id=EG12842 EnsemblBacteria AAC73937 http://www.ensemblgenomes.org/id/AAC73937 EnsemblBacteria AAC73937 http://www.ensemblgenomes.org/id/AAC73937 EnsemblBacteria BAA35561 http://www.ensemblgenomes.org/id/BAA35561 EnsemblBacteria BAA35561 http://www.ensemblgenomes.org/id/BAA35561 EnsemblBacteria BAA35561 http://www.ensemblgenomes.org/id/BAA35561 EnsemblBacteria b0850 http://www.ensemblgenomes.org/id/b0850 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945481 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945481 HOGENOM HOG000118238 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118238&db=HOGENOM6 InterPro IPR010815 http://www.ebi.ac.uk/interpro/entry/IPR010815 KEGG_Gene ecj:JW0834 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0834 KEGG_Gene eco:b0850 http://www.genome.jp/dbget-bin/www_bget?eco:b0850 OMA IGMMSLA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IGMMSLA PSORT swissprot:YBJC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBJC_ECOLI PSORT-B swissprot:YBJC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBJC_ECOLI PSORT2 swissprot:YBJC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBJC_ECOLI Pfam PF07214 http://pfam.xfam.org/family/PF07214 Phobius swissprot:YBJC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBJC_ECOLI ProteinModelPortal P46119 http://www.proteinmodelportal.org/query/uniprot/P46119 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3530878 http://www.ncbi.nlm.nih.gov/pubmed/3530878 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415371 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415371 RefSeq WP_001201560 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001201560 STRING 511145.b0850 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0850&targetmode=cogs UniProtKB YBJC_ECOLI http://www.uniprot.org/uniprot/YBJC_ECOLI UniProtKB-AC P46119 http://www.uniprot.org/uniprot/P46119 charge swissprot:YBJC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBJC_ECOLI eggNOG ENOG4105X20 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105X20 eggNOG ENOG41125IT http://eggnogapi.embl.de/nog_data/html/tree/ENOG41125IT epestfind swissprot:YBJC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBJC_ECOLI garnier swissprot:YBJC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBJC_ECOLI helixturnhelix swissprot:YBJC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBJC_ECOLI hmoment swissprot:YBJC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBJC_ECOLI iep swissprot:YBJC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBJC_ECOLI inforesidue swissprot:YBJC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBJC_ECOLI octanol swissprot:YBJC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBJC_ECOLI pepcoil swissprot:YBJC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBJC_ECOLI pepdigest swissprot:YBJC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBJC_ECOLI pepinfo swissprot:YBJC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBJC_ECOLI pepnet swissprot:YBJC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBJC_ECOLI pepstats swissprot:YBJC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBJC_ECOLI pepwheel swissprot:YBJC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBJC_ECOLI pepwindow swissprot:YBJC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBJC_ECOLI sigcleave swissprot:YBJC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBJC_ECOLI ## Database ID URL or Descriptions # AltName Peptidase M {ECO:0000255|HAMAP-Rule MF_01974} # BIOPHYSICOCHEMICAL PROPERTIES MAP1_ECOLI Kinetic parameters KM=2.0 mM for a Met-Gly-Met-Met peptide (for the Fe(2+)- complexed enzyme) {ECO 0000269|PubMed 10460163, ECO 0000269|PubMed 12755633, ECO 0000269|PubMed 18855426, ECO 0000269|PubMed 19019076}; KM=1.3 mM for a Met-Gly-Met-Met peptide (for the Mn(2+)- complexed enzyme) {ECO 0000269|PubMed 10460163, ECO 0000269|PubMed 12755633, ECO 0000269|PubMed 18855426, ECO 0000269|PubMed 19019076}; KM=3.2 mM for a Met-Gly-Met-Met peptide (for the Co(2+)- complexed enzyme) {ECO 0000269|PubMed 10460163, ECO 0000269|PubMed 12755633, ECO 0000269|PubMed 18855426, ECO 0000269|PubMed 19019076}; Vmax=55 umol/min/mg enzyme (for the Fe(2+)-complexed enzyme) {ECO 0000269|PubMed 10460163, ECO 0000269|PubMed 12755633, ECO 0000269|PubMed 18855426, ECO 0000269|PubMed 19019076}; Vmax=77 umol/min/mg enzyme (for the Co(2+)-complexed enzyme) {ECO 0000269|PubMed 10460163, ECO 0000269|PubMed 12755633, ECO 0000269|PubMed 18855426, ECO 0000269|PubMed 19019076}; # BRENDA 3.4.11.18 2026 # BioGrid 4262194 9 # CATALYTIC ACTIVITY MAP1_ECOLI Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides. {ECO 0000255|HAMAP-Rule MF_01974, ECO 0000269|PubMed 17120228, ECO 0000269|PubMed 20521764, ECO 0000269|PubMed 3027045}. # CDD cd01086 MetAP1 # COFACTOR MAP1_ECOLI Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000255|HAMAP-Rule MF_01974, ECO 0000269|PubMed 10387007, ECO 0000269|PubMed 10460163, ECO 0000269|PubMed 10555963, ECO 0000269|PubMed 10736182, ECO 0000269|PubMed 17120228, ECO 0000269|PubMed 20017927}; Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000255|HAMAP-Rule MF_01974, ECO 0000269|PubMed 10460163}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000255|HAMAP-Rule MF_01974, ECO 0000269|PubMed 10460163, ECO 0000269|PubMed 16769889, ECO 0000269|PubMed 18093325}; Name=Fe(2+); Xref=ChEBI CHEBI 29033; Evidence={ECO 0000255|HAMAP-Rule MF_01974, ECO 0000269|PubMed 10460163, ECO 0000269|PubMed 10736182, ECO 0000269|PubMed 18785729, ECO 0000269|PubMed 22112844}; Note=Binds 2 divalent metal cations per subunit. Has a high- affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)- metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site. {ECO 0000255|HAMAP- Rule MF_01974, ECO 0000269|PubMed 10460163, ECO 0000269|PubMed 16769889, ECO 0000269|PubMed 18785729, ECO 0000269|PubMed 22112844}; # COFACTOR MAP1_ECOLI Name=Na(+); Xref=ChEBI CHEBI 29101; Evidence={ECO 0000269|PubMed 10387007}; Note=Binds 1 sodium ion per subunit. The sodium ion has a structural role. {ECO 0000269|PubMed 10387007}; # EcoGene EG10570 map # FUNCTION MAP1_ECOLI Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed. {ECO 0000255|HAMAP-Rule MF_01974, ECO 0000269|PubMed 20521764, ECO 0000269|PubMed 3027045}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008198 ferrous iron binding; IDA:EcoCyc. # GO_function GO:0070006 metalloaminopeptidase activity; IDA:EcoCyc. # GO_process GO:0070084 protein initiator methionine removal; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # Gene3D 3.90.230.10 -; 1. # HAMAP MF_01974 MetAP_1 # IntAct P0AE18 25 # InterPro IPR000994 Pept_M24 # InterPro IPR001714 Pept_M24_MAP # InterPro IPR002467 Pept_M24A_MAP1 # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # Organism MAP1_ECOLI Escherichia coli (strain K12) # PATRIC 32115443 VBIEscCol129921_0173 # PDB 1C21 X-ray; 1.80 A; A=2-264 # PDB 1C22 X-ray; 1.75 A; A=2-264 # PDB 1C23 X-ray; 2.00 A; A=2-264 # PDB 1C24 X-ray; 1.70 A; A=2-264 # PDB 1C27 X-ray; 1.95 A; A=2-264 # PDB 1MAT X-ray; 2.40 A; A=1-264 # PDB 1XNZ X-ray; 1.52 A; A=1-264 # PDB 1YVM X-ray; 1.60 A; A=1-264 # PDB 2BB7 X-ray; 1.70 A; A=1-264 # PDB 2EVC X-ray; 1.60 A; A=1-264 # PDB 2EVM X-ray; 1.70 A; A=1-264 # PDB 2EVO X-ray; 1.70 A; A/B=1-264 # PDB 2GG0 X-ray; 1.28 A; A=2-264 # PDB 2GG2 X-ray; 1.00 A; A=2-264 # PDB 2GG3 X-ray; 1.45 A; A=2-264 # PDB 2GG5 X-ray; 2.12 A; A=2-264 # PDB 2GG7 X-ray; 1.12 A; A=2-264 # PDB 2GG8 X-ray; 1.80 A; A=2-264 # PDB 2GG9 X-ray; 1.05 A; A=2-264 # PDB 2GGB X-ray; 2.13 A; A=2-264 # PDB 2GGC X-ray; 1.00 A; A=2-264 # PDB 2GTX X-ray; 2.00 A; A/B=4-264 # PDB 2GU4 X-ray; 1.80 A; A/B=2-264 # PDB 2GU5 X-ray; 1.60 A; A/B=2-264 # PDB 2GU6 X-ray; 1.70 A; A/B=2-264 # PDB 2GU7 X-ray; 2.00 A; A/B=2-264 # PDB 2MAT X-ray; 1.90 A; A=1-264 # PDB 2P98 X-ray; 1.70 A; A=2-262 # PDB 2P99 X-ray; 1.80 A; A=2-262 # PDB 2P9A X-ray; 1.60 A; A=2-263 # PDB 2Q92 X-ray; 1.90 A; A=2-263 # PDB 2Q93 X-ray; 1.60 A; A=2-264 # PDB 2Q94 X-ray; 1.63 A; A=2-263 # PDB 2Q95 X-ray; 1.70 A; A=2-264 # PDB 2Q96 X-ray; 1.60 A; A=2-264 # PDB 3D27 X-ray; 2.20 A; A=4-264 # PDB 3MAT X-ray; 2.00 A; A=1-264 # PDB 4MAT X-ray; 2.00 A; A=1-264 # PDB 4Z7M X-ray; 1.43 A; A/B=2-262 # PIR A27761 DPECM # PRINTS PR00599 MAPEPTIDASE # PROSITE PS00680 MAP_1 # Pfam PF00557 Peptidase_M24 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Methionine aminopeptidase {ECO:0000255|HAMAP-Rule MF_01974} # RefSeq NP_414710 NC_000913.3 # RefSeq WP_001018194 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. {ECO:0000255|HAMAP- Rule MF_01974}. # SUBUNIT MAP1_ECOLI Monomer. {ECO 0000255|HAMAP-Rule MF_01974, ECO 0000269|PubMed 10387007, ECO 0000269|PubMed 16769889}. # SUPFAM SSF55920 SSF55920 # TIGRFAMs TIGR00500 met_pdase_I # eggNOG COG0024 LUCA # eggNOG ENOG4105CA1 Bacteria BLAST swissprot:MAP1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MAP1_ECOLI BioCyc ECOL316407:JW0163-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0163-MONOMER BioCyc EcoCyc:EG10570-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10570-MONOMER BioCyc MetaCyc:EG10570-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10570-MONOMER COG COG0024 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0024 DIP DIP-48040N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48040N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/prot.21207 http://dx.doi.org/10.1002/prot.21207 DOI 10.1016/j.jinorgbio.2011.09.020 http://dx.doi.org/10.1016/j.jinorgbio.2011.09.020 DOI 10.1021/bi00066a009 http://dx.doi.org/10.1021/bi00066a009 DOI 10.1021/bi027327s http://dx.doi.org/10.1021/bi027327s DOI 10.1021/bi1005464 http://dx.doi.org/10.1021/bi1005464 DOI 10.1021/bi801499g http://dx.doi.org/10.1021/bi801499g DOI 10.1021/bi990684r http://dx.doi.org/10.1021/bi990684r DOI 10.1021/bi990872h http://dx.doi.org/10.1021/bi990872h DOI 10.1021/bi991711g http://dx.doi.org/10.1021/bi991711g DOI 10.1021/bi9925827 http://dx.doi.org/10.1021/bi9925827 DOI 10.1021/jm8005788 http://dx.doi.org/10.1021/jm8005788 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0602433103 http://dx.doi.org/10.1073/pnas.0602433103 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1111/j.1742-4658.2008.06749.x http://dx.doi.org/10.1111/j.1742-4658.2008.06749.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1186/1471-2091-10-32 http://dx.doi.org/10.1186/1471-2091-10-32 DOI 10.1186/1472-6807-7-84 http://dx.doi.org/10.1186/1472-6807-7-84 EC_number EC:3.4.11.18 {ECO:0000255|HAMAP-Rule:MF_01974} http://www.genome.jp/dbget-bin/www_bget?EC:3.4.11.18 {ECO:0000255|HAMAP-Rule:MF_01974} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M15106 http://www.ebi.ac.uk/ena/data/view/M15106 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 ENZYME 3.4.11.18 {ECO:0000255|HAMAP-Rule:MF_01974} http://enzyme.expasy.org/EC/3.4.11.18 {ECO:0000255|HAMAP-Rule:MF_01974} EchoBASE EB0565 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0565 EcoGene EG10570 http://www.ecogene.org/geneInfo.php?eg_id=EG10570 EnsemblBacteria AAC73279 http://www.ensemblgenomes.org/id/AAC73279 EnsemblBacteria AAC73279 http://www.ensemblgenomes.org/id/AAC73279 EnsemblBacteria BAB96743 http://www.ensemblgenomes.org/id/BAB96743 EnsemblBacteria BAB96743 http://www.ensemblgenomes.org/id/BAB96743 EnsemblBacteria BAB96743 http://www.ensemblgenomes.org/id/BAB96743 EnsemblBacteria b0168 http://www.ensemblgenomes.org/id/b0168 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008198 GO_function GO:0070006 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070006 GO_process GO:0070084 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070084 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 Gene3D 3.90.230.10 http://www.cathdb.info/version/latest/superfamily/3.90.230.10 GeneID 947882 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947882 HAMAP MF_01974 http://hamap.expasy.org/unirule/MF_01974 HOGENOM HOG000030427 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000030427&db=HOGENOM6 InParanoid P0AE18 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AE18 IntAct P0AE18 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AE18* IntEnz 3.4.11.18 {ECO:0000255|HAMAP-Rule:MF_01974} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.11.18 {ECO:0000255|HAMAP-Rule:MF_01974} InterPro IPR000994 http://www.ebi.ac.uk/interpro/entry/IPR000994 InterPro IPR001714 http://www.ebi.ac.uk/interpro/entry/IPR001714 InterPro IPR002467 http://www.ebi.ac.uk/interpro/entry/IPR002467 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW0163 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0163 KEGG_Gene eco:b0168 http://www.genome.jp/dbget-bin/www_bget?eco:b0168 KEGG_Orthology KO:K01265 http://www.genome.jp/dbget-bin/www_bget?KO:K01265 MINT MINT-1219572 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1219572 OMA VIKDEYH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VIKDEYH PDB 1C21 http://www.ebi.ac.uk/pdbe-srv/view/entry/1C21 PDB 1C22 http://www.ebi.ac.uk/pdbe-srv/view/entry/1C22 PDB 1C23 http://www.ebi.ac.uk/pdbe-srv/view/entry/1C23 PDB 1C24 http://www.ebi.ac.uk/pdbe-srv/view/entry/1C24 PDB 1C27 http://www.ebi.ac.uk/pdbe-srv/view/entry/1C27 PDB 1MAT http://www.ebi.ac.uk/pdbe-srv/view/entry/1MAT PDB 1XNZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1XNZ PDB 1YVM http://www.ebi.ac.uk/pdbe-srv/view/entry/1YVM PDB 2BB7 http://www.ebi.ac.uk/pdbe-srv/view/entry/2BB7 PDB 2EVC http://www.ebi.ac.uk/pdbe-srv/view/entry/2EVC PDB 2EVM http://www.ebi.ac.uk/pdbe-srv/view/entry/2EVM PDB 2EVO http://www.ebi.ac.uk/pdbe-srv/view/entry/2EVO PDB 2GG0 http://www.ebi.ac.uk/pdbe-srv/view/entry/2GG0 PDB 2GG2 http://www.ebi.ac.uk/pdbe-srv/view/entry/2GG2 PDB 2GG3 http://www.ebi.ac.uk/pdbe-srv/view/entry/2GG3 PDB 2GG5 http://www.ebi.ac.uk/pdbe-srv/view/entry/2GG5 PDB 2GG7 http://www.ebi.ac.uk/pdbe-srv/view/entry/2GG7 PDB 2GG8 http://www.ebi.ac.uk/pdbe-srv/view/entry/2GG8 PDB 2GG9 http://www.ebi.ac.uk/pdbe-srv/view/entry/2GG9 PDB 2GGB http://www.ebi.ac.uk/pdbe-srv/view/entry/2GGB PDB 2GGC http://www.ebi.ac.uk/pdbe-srv/view/entry/2GGC PDB 2GTX http://www.ebi.ac.uk/pdbe-srv/view/entry/2GTX PDB 2GU4 http://www.ebi.ac.uk/pdbe-srv/view/entry/2GU4 PDB 2GU5 http://www.ebi.ac.uk/pdbe-srv/view/entry/2GU5 PDB 2GU6 http://www.ebi.ac.uk/pdbe-srv/view/entry/2GU6 PDB 2GU7 http://www.ebi.ac.uk/pdbe-srv/view/entry/2GU7 PDB 2MAT http://www.ebi.ac.uk/pdbe-srv/view/entry/2MAT PDB 2P98 http://www.ebi.ac.uk/pdbe-srv/view/entry/2P98 PDB 2P99 http://www.ebi.ac.uk/pdbe-srv/view/entry/2P99 PDB 2P9A http://www.ebi.ac.uk/pdbe-srv/view/entry/2P9A PDB 2Q92 http://www.ebi.ac.uk/pdbe-srv/view/entry/2Q92 PDB 2Q93 http://www.ebi.ac.uk/pdbe-srv/view/entry/2Q93 PDB 2Q94 http://www.ebi.ac.uk/pdbe-srv/view/entry/2Q94 PDB 2Q95 http://www.ebi.ac.uk/pdbe-srv/view/entry/2Q95 PDB 2Q96 http://www.ebi.ac.uk/pdbe-srv/view/entry/2Q96 PDB 3D27 http://www.ebi.ac.uk/pdbe-srv/view/entry/3D27 PDB 3MAT http://www.ebi.ac.uk/pdbe-srv/view/entry/3MAT PDB 4MAT http://www.ebi.ac.uk/pdbe-srv/view/entry/4MAT PDB 4Z7M http://www.ebi.ac.uk/pdbe-srv/view/entry/4Z7M PDBsum 1C21 http://www.ebi.ac.uk/pdbsum/1C21 PDBsum 1C22 http://www.ebi.ac.uk/pdbsum/1C22 PDBsum 1C23 http://www.ebi.ac.uk/pdbsum/1C23 PDBsum 1C24 http://www.ebi.ac.uk/pdbsum/1C24 PDBsum 1C27 http://www.ebi.ac.uk/pdbsum/1C27 PDBsum 1MAT http://www.ebi.ac.uk/pdbsum/1MAT PDBsum 1XNZ http://www.ebi.ac.uk/pdbsum/1XNZ PDBsum 1YVM http://www.ebi.ac.uk/pdbsum/1YVM PDBsum 2BB7 http://www.ebi.ac.uk/pdbsum/2BB7 PDBsum 2EVC http://www.ebi.ac.uk/pdbsum/2EVC PDBsum 2EVM http://www.ebi.ac.uk/pdbsum/2EVM PDBsum 2EVO http://www.ebi.ac.uk/pdbsum/2EVO PDBsum 2GG0 http://www.ebi.ac.uk/pdbsum/2GG0 PDBsum 2GG2 http://www.ebi.ac.uk/pdbsum/2GG2 PDBsum 2GG3 http://www.ebi.ac.uk/pdbsum/2GG3 PDBsum 2GG5 http://www.ebi.ac.uk/pdbsum/2GG5 PDBsum 2GG7 http://www.ebi.ac.uk/pdbsum/2GG7 PDBsum 2GG8 http://www.ebi.ac.uk/pdbsum/2GG8 PDBsum 2GG9 http://www.ebi.ac.uk/pdbsum/2GG9 PDBsum 2GGB http://www.ebi.ac.uk/pdbsum/2GGB PDBsum 2GGC http://www.ebi.ac.uk/pdbsum/2GGC PDBsum 2GTX http://www.ebi.ac.uk/pdbsum/2GTX PDBsum 2GU4 http://www.ebi.ac.uk/pdbsum/2GU4 PDBsum 2GU5 http://www.ebi.ac.uk/pdbsum/2GU5 PDBsum 2GU6 http://www.ebi.ac.uk/pdbsum/2GU6 PDBsum 2GU7 http://www.ebi.ac.uk/pdbsum/2GU7 PDBsum 2MAT http://www.ebi.ac.uk/pdbsum/2MAT PDBsum 2P98 http://www.ebi.ac.uk/pdbsum/2P98 PDBsum 2P99 http://www.ebi.ac.uk/pdbsum/2P99 PDBsum 2P9A http://www.ebi.ac.uk/pdbsum/2P9A PDBsum 2Q92 http://www.ebi.ac.uk/pdbsum/2Q92 PDBsum 2Q93 http://www.ebi.ac.uk/pdbsum/2Q93 PDBsum 2Q94 http://www.ebi.ac.uk/pdbsum/2Q94 PDBsum 2Q95 http://www.ebi.ac.uk/pdbsum/2Q95 PDBsum 2Q96 http://www.ebi.ac.uk/pdbsum/2Q96 PDBsum 3D27 http://www.ebi.ac.uk/pdbsum/3D27 PDBsum 3MAT http://www.ebi.ac.uk/pdbsum/3MAT PDBsum 4MAT http://www.ebi.ac.uk/pdbsum/4MAT PDBsum 4Z7M http://www.ebi.ac.uk/pdbsum/4Z7M PRINTS PR00599 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00599 PROSITE PS00680 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00680 PSORT swissprot:MAP1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MAP1_ECOLI PSORT-B swissprot:MAP1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MAP1_ECOLI PSORT2 swissprot:MAP1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MAP1_ECOLI Pfam PF00557 http://pfam.xfam.org/family/PF00557 Phobius swissprot:MAP1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MAP1_ECOLI PhylomeDB P0AE18 http://phylomedb.org/?seqid=P0AE18 ProteinModelPortal P0AE18 http://www.proteinmodelportal.org/query/uniprot/P0AE18 PubMed 10387007 http://www.ncbi.nlm.nih.gov/pubmed/10387007 PubMed 10460163 http://www.ncbi.nlm.nih.gov/pubmed/10460163 PubMed 10555963 http://www.ncbi.nlm.nih.gov/pubmed/10555963 PubMed 10736182 http://www.ncbi.nlm.nih.gov/pubmed/10736182 PubMed 12755633 http://www.ncbi.nlm.nih.gov/pubmed/12755633 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16769889 http://www.ncbi.nlm.nih.gov/pubmed/16769889 PubMed 17120228 http://www.ncbi.nlm.nih.gov/pubmed/17120228 PubMed 18093325 http://www.ncbi.nlm.nih.gov/pubmed/18093325 PubMed 18785729 http://www.ncbi.nlm.nih.gov/pubmed/18785729 PubMed 18855426 http://www.ncbi.nlm.nih.gov/pubmed/18855426 PubMed 19019076 http://www.ncbi.nlm.nih.gov/pubmed/19019076 PubMed 20017927 http://www.ncbi.nlm.nih.gov/pubmed/20017927 PubMed 20521764 http://www.ncbi.nlm.nih.gov/pubmed/20521764 PubMed 22112844 http://www.ncbi.nlm.nih.gov/pubmed/22112844 PubMed 3027045 http://www.ncbi.nlm.nih.gov/pubmed/3027045 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 8471602 http://www.ncbi.nlm.nih.gov/pubmed/8471602 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_414710 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414710 RefSeq WP_001018194 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001018194 SMR P0AE18 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AE18 STRING 511145.b0168 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0168&targetmode=cogs STRING COG0024 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0024&targetmode=cogs SUPFAM SSF55920 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55920 SWISS-2DPAGE P0AE18 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AE18 TIGRFAMs TIGR00500 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00500 UniProtKB MAP1_ECOLI http://www.uniprot.org/uniprot/MAP1_ECOLI UniProtKB-AC P0AE18 http://www.uniprot.org/uniprot/P0AE18 charge swissprot:MAP1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MAP1_ECOLI eggNOG COG0024 http://eggnogapi.embl.de/nog_data/html/tree/COG0024 eggNOG ENOG4105CA1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CA1 epestfind swissprot:MAP1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MAP1_ECOLI garnier swissprot:MAP1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MAP1_ECOLI helixturnhelix swissprot:MAP1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MAP1_ECOLI hmoment swissprot:MAP1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MAP1_ECOLI iep swissprot:MAP1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MAP1_ECOLI inforesidue swissprot:MAP1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MAP1_ECOLI octanol swissprot:MAP1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MAP1_ECOLI pepcoil swissprot:MAP1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MAP1_ECOLI pepdigest swissprot:MAP1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MAP1_ECOLI pepinfo swissprot:MAP1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MAP1_ECOLI pepnet swissprot:MAP1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MAP1_ECOLI pepstats swissprot:MAP1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MAP1_ECOLI pepwheel swissprot:MAP1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MAP1_ECOLI pepwindow swissprot:MAP1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MAP1_ECOLI sigcleave swissprot:MAP1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MAP1_ECOLI ## Database ID URL or Descriptions # BioGrid 4259113 149 # CDD cd06174 MFS # EcoGene EG11640 ydeE # FUNCTION YDEE_ECOLI A transporter able to export peptides. When overexpressed, allows cells deleted for multiple peptidases (pepA, pepB, pepD and pepN) to grow in the presence of dipeptides Ala-Gln or Gly-Tyr which otherwise inhibit growth (PubMed 20067529). Cells overexpressing this protein have decreased intracellular levels of Ala-Gln dipeptide, and in a system that produces the Ala-Gln dipeptide overproduction of this protein increases export of the dipeptide (PubMed 20067529). {ECO 0000269|PubMed 20067529}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0071916 dipeptide transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0015031 protein transport; IEA:UniProtKB-KW. # GO_process GO:0035442 dipeptide transmembrane transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # Organism YDEE_ECOLI Escherichia coli (strain K12) # PATRIC 32118366 VBIEscCol129921_1603 # PIR A64908 A64908 # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDEE_ECOLI Uncharacterized MFS-type transporter YdeE # RefSeq NP_416051 NC_000913.3 # RefSeq WP_001054204 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=M96235; Type=Frameshift; Positions=145; Note=Produces two separate ORFS.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the major facilitator superfamily. {ECO 0000305}. # SUBCELLULAR LOCATION YDEE_ECOLI Cell inner membrane {ECO 0000305}; Multi- pass membrane protein {ECO 0000305}. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.2.55 the major facilitator superfamily (mfs) # eggNOG ENOG4105E5W Bacteria # eggNOG ENOG410ZDMF LUCA BLAST swissprot:YDEE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDEE_ECOLI BioCyc ECOL316407:JW1527-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1527-MONOMER BioCyc EcoCyc:YDEF-MONOMER http://biocyc.org/getid?id=EcoCyc:YDEF-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1111/j.1574-6968.2009.01879.x http://dx.doi.org/10.1111/j.1574-6968.2009.01879.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M96235 http://www.ebi.ac.uk/ena/data/view/M96235 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1595 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1595 EcoGene EG11640 http://www.ecogene.org/geneInfo.php?eg_id=EG11640 EnsemblBacteria AAC74607 http://www.ensemblgenomes.org/id/AAC74607 EnsemblBacteria AAC74607 http://www.ensemblgenomes.org/id/AAC74607 EnsemblBacteria BAA15224 http://www.ensemblgenomes.org/id/BAA15224 EnsemblBacteria BAA15224 http://www.ensemblgenomes.org/id/BAA15224 EnsemblBacteria BAA15224 http://www.ensemblgenomes.org/id/BAA15224 EnsemblBacteria b1534 http://www.ensemblgenomes.org/id/b1534 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0071916 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071916 GO_process GO:0015031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031 GO_process GO:0035442 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035442 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 946083 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946083 HOGENOM HOG000120784 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120784&db=HOGENOM6 InParanoid P31126 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31126 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Gene ecj:JW1527 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1527 KEGG_Gene eco:b1534 http://www.genome.jp/dbget-bin/www_bget?eco:b1534 OMA KGMADSY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KGMADSY PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:YDEE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDEE_ECOLI PSORT-B swissprot:YDEE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDEE_ECOLI PSORT2 swissprot:YDEE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDEE_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:YDEE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDEE_ECOLI PhylomeDB P31126 http://phylomedb.org/?seqid=P31126 ProteinModelPortal P31126 http://www.proteinmodelportal.org/query/uniprot/P31126 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20067529 http://www.ncbi.nlm.nih.gov/pubmed/20067529 PubMed 8383113 http://www.ncbi.nlm.nih.gov/pubmed/8383113 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416051 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416051 RefSeq WP_001054204 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001054204 STRING 511145.b1534 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1534&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.2.55 http://www.tcdb.org/search/result.php?tc=2.A.1.2.55 UniProtKB YDEE_ECOLI http://www.uniprot.org/uniprot/YDEE_ECOLI UniProtKB-AC P31126 http://www.uniprot.org/uniprot/P31126 charge swissprot:YDEE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDEE_ECOLI eggNOG ENOG4105E5W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E5W eggNOG ENOG410ZDMF http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZDMF epestfind swissprot:YDEE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDEE_ECOLI garnier swissprot:YDEE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDEE_ECOLI helixturnhelix swissprot:YDEE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDEE_ECOLI hmoment swissprot:YDEE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDEE_ECOLI iep swissprot:YDEE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDEE_ECOLI inforesidue swissprot:YDEE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDEE_ECOLI octanol swissprot:YDEE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDEE_ECOLI pepcoil swissprot:YDEE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDEE_ECOLI pepdigest swissprot:YDEE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDEE_ECOLI pepinfo swissprot:YDEE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDEE_ECOLI pepnet swissprot:YDEE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDEE_ECOLI pepstats swissprot:YDEE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDEE_ECOLI pepwheel swissprot:YDEE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDEE_ECOLI pepwindow swissprot:YDEE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDEE_ECOLI sigcleave swissprot:YDEE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDEE_ECOLI ## Database ID URL or Descriptions # AltName FLIY_ECOLI Protein FliY # AltName FLIY_ECOLI Sulfate starvation-induced protein 7 # BioGrid 4261251 13 # DISRUPTION PHENOTYPE The fliY-ydjN double mutant is completely resistant to both L-selenaproline and L-selenocystine. {ECO:0000269|PubMed 25139244}. # ENZYME REGULATION The FliY-YecC-YecS system is inhibited by L- cystine, L-cysteine, DL-2,6-diaminopimelic acid and L- cystathionine, and is stimulated by D-cysteine. {ECO:0000269|PubMed 25139244}. # EcoGene EG12680 fliY # FUNCTION FLIY_ECOLI Part of the ABC transporter complex FliY-YecC-YecS involved in L-cystine transport. The system can probably also transport L-cysteine, and it mediates accumulation of the toxic compounds L-selenaproline (SCA) and L-selenocystine (SeCys). Binds cystine (PubMed 8450713). {ECO 0000269|PubMed 25139244, ECO 0000269|PubMed 8450713}. # GO_component GO:0016020 membrane; IEA:InterPro. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0004970 ionotropic glutamate receptor activity; IEA:InterPro. # GO_function GO:0015184 L-cystine transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0033229 cysteine transmembrane transporter activity; IDA:EcoCyc. # GO_process GO:0015811 L-cystine transport; IDA:EcoCyc. # GO_process GO:0042883 cysteine transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # INDUCTION Repressed by sulfate or cysteine. {ECO:0000269|PubMed 8774726}. # IntAct P0AEM9 9 # InterPro IPR001320 Iontro_rcpt # InterPro IPR001638 Solute-binding_3/MltF_N # InterPro IPR018313 SBP_3_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00234 Cystine transport system # KEGG_Brite ko02000 Transporters # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Pathway ko02010 ABC transporters # Organism FLIY_ECOLI Escherichia coli (strain K12) # PATRIC 32119175 VBIEscCol129921_2002 # PIR E64955 E64955 # PROSITE PS01039 SBP_BACTERIAL_3 # Pfam PF00497 SBP_bac_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName L-cystine-binding protein FliY {ECO 0000305} # RefSeq NP_416430 NC_000913.3 # RefSeq WP_001296168 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial solute-binding protein 3 family. {ECO 0000305}. # SMART SM00062 PBPb # SMART SM00079 PBPe # SUBCELLULAR LOCATION FLIY_ECOLI Periplasm. # SUBUNIT The complex is composed of two ATP-binding proteins (YecC), two transmembrane proteins (YecS) and a solute-binding protein (FliY). {ECO 0000305}. # TCDB 3.A.1.3.10 the atp-binding cassette (abc) superfamily # eggNOG COG0834 LUCA # eggNOG ENOG4105EAB Bacteria BLAST swissprot:FLIY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLIY_ECOLI BioCyc ECOL316407:JW1905-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1905-MONOMER BioCyc EcoCyc:G7039-MONOMER http://biocyc.org/getid?id=EcoCyc:G7039-MONOMER BioCyc MetaCyc:G7039-MONOMER http://biocyc.org/getid?id=MetaCyc:G7039-MONOMER COG COG0834 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0834 DIP DIP-47980N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47980N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1016/0024-3205(93)90103-A http://dx.doi.org/10.1016/0024-3205(93)90103-A DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1111/j.1432-1033.1996.0773u.x http://dx.doi.org/10.1111/j.1432-1033.1996.0773u.x DOI 10.1111/jam.12623 http://dx.doi.org/10.1111/jam.12623 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18539 http://www.ebi.ac.uk/ena/data/view/U18539 EchoBASE EB2545 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2545 EcoGene EG12680 http://www.ecogene.org/geneInfo.php?eg_id=EG12680 EnsemblBacteria AAC74987 http://www.ensemblgenomes.org/id/AAC74987 EnsemblBacteria AAC74987 http://www.ensemblgenomes.org/id/AAC74987 EnsemblBacteria BAA15740 http://www.ensemblgenomes.org/id/BAA15740 EnsemblBacteria BAA15740 http://www.ensemblgenomes.org/id/BAA15740 EnsemblBacteria BAA15740 http://www.ensemblgenomes.org/id/BAA15740 EnsemblBacteria b1920 http://www.ensemblgenomes.org/id/b1920 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0004970 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004970 GO_function GO:0015184 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015184 GO_function GO:0033229 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033229 GO_process GO:0015811 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015811 GO_process GO:0042883 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042883 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948833 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948833 HOGENOM HOG000031895 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000031895&db=HOGENOM6 InParanoid P0AEM9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEM9 IntAct P0AEM9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEM9* InterPro IPR001320 http://www.ebi.ac.uk/interpro/entry/IPR001320 InterPro IPR001638 http://www.ebi.ac.uk/interpro/entry/IPR001638 InterPro IPR018313 http://www.ebi.ac.uk/interpro/entry/IPR018313 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW1905 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1905 KEGG_Gene eco:b1920 http://www.genome.jp/dbget-bin/www_bget?eco:b1920 KEGG_Orthology KO:K02424 http://www.genome.jp/dbget-bin/www_bget?KO:K02424 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 MINT MINT-1231539 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1231539 OMA TVKWQSI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TVKWQSI PROSITE PS01039 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01039 PSORT swissprot:FLIY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLIY_ECOLI PSORT-B swissprot:FLIY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLIY_ECOLI PSORT2 swissprot:FLIY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLIY_ECOLI Pfam PF00497 http://pfam.xfam.org/family/PF00497 Phobius swissprot:FLIY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLIY_ECOLI PhylomeDB P0AEM9 http://phylomedb.org/?seqid=P0AEM9 ProteinModelPortal P0AEM9 http://www.proteinmodelportal.org/query/uniprot/P0AEM9 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 25139244 http://www.ncbi.nlm.nih.gov/pubmed/25139244 PubMed 8450713 http://www.ncbi.nlm.nih.gov/pubmed/8450713 PubMed 8550423 http://www.ncbi.nlm.nih.gov/pubmed/8550423 PubMed 8774726 http://www.ncbi.nlm.nih.gov/pubmed/8774726 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_416430 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416430 RefSeq WP_001296168 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001296168 SMART SM00062 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00062 SMART SM00079 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00079 SMR P0AEM9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEM9 STRING 511145.b1920 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1920&targetmode=cogs STRING COG0834 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0834&targetmode=cogs SWISS-2DPAGE P0AEM9 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AEM9 TCDB 3.A.1.3.10 http://www.tcdb.org/search/result.php?tc=3.A.1.3.10 UniProtKB FLIY_ECOLI http://www.uniprot.org/uniprot/FLIY_ECOLI UniProtKB-AC P0AEM9 http://www.uniprot.org/uniprot/P0AEM9 charge swissprot:FLIY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLIY_ECOLI eggNOG COG0834 http://eggnogapi.embl.de/nog_data/html/tree/COG0834 eggNOG ENOG4105EAB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EAB epestfind swissprot:FLIY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLIY_ECOLI garnier swissprot:FLIY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLIY_ECOLI helixturnhelix swissprot:FLIY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLIY_ECOLI hmoment swissprot:FLIY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLIY_ECOLI iep swissprot:FLIY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLIY_ECOLI inforesidue swissprot:FLIY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLIY_ECOLI octanol swissprot:FLIY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLIY_ECOLI pepcoil swissprot:FLIY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLIY_ECOLI pepdigest swissprot:FLIY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLIY_ECOLI pepinfo swissprot:FLIY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLIY_ECOLI pepnet swissprot:FLIY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLIY_ECOLI pepstats swissprot:FLIY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLIY_ECOLI pepwheel swissprot:FLIY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLIY_ECOLI pepwindow swissprot:FLIY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLIY_ECOLI sigcleave swissprot:FLIY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLIY_ECOLI ## Database ID URL or Descriptions # BioGrid 4262448 147 # CDD cd00555 Maf # EcoGene EG11298 yhdE # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0036218 dTTP diphosphatase activity; IDA:EcoCyc. # GO_function GO:0036221 UTP diphosphatase activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0047429 nucleoside-triphosphate diphosphatase activity; IDA:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # Gene3D 3.90.950.10 -; 1. # HAMAP MF_00528 Maf # IntAct P25536 4 # InterPro IPR003697 Maf # InterPro IPR029001 ITPase-like_fam # Organism YHDE_ECOLI Escherichia coli (strain K12) # PATRIC 32121922 VBIEscCol129921_3345 # PDB 4P0E X-ray; 2.30 A; A/B=2-190 # PIR JQ1271 JQ1271 # PIRSF PIRSF006305 Maf # Pfam PF02545 Maf # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHDE_ECOLI Maf-like protein YhdE # RefSeq NP_417714 NC_000913.3 # RefSeq WP_000203105 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA58051.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the maf family. {ECO 0000305}. # SUBCELLULAR LOCATION YHDE_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF52972 SSF52972 # TIGRFAMs TIGR00172 maf # eggNOG COG0424 LUCA # eggNOG ENOG4108Z03 Bacteria BLAST swissprot:YHDE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHDE_ECOLI BioCyc ECOL316407:JW3217-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3217-MONOMER BioCyc EcoCyc:EG11298-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11298-MONOMER BioCyc MetaCyc:EG11298-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11298-MONOMER COG COG0424 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0424 DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1016/0378-1119(91)90578-Y http://dx.doi.org/10.1016/0378-1119(91)90578-Y DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X57166 http://www.ebi.ac.uk/ena/data/view/X57166 EchoBASE EB1275 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1275 EcoGene EG11298 http://www.ecogene.org/geneInfo.php?eg_id=EG11298 EnsemblBacteria AAC76280 http://www.ensemblgenomes.org/id/AAC76280 EnsemblBacteria AAC76280 http://www.ensemblgenomes.org/id/AAC76280 EnsemblBacteria BAE77290 http://www.ensemblgenomes.org/id/BAE77290 EnsemblBacteria BAE77290 http://www.ensemblgenomes.org/id/BAE77290 EnsemblBacteria BAE77290 http://www.ensemblgenomes.org/id/BAE77290 EnsemblBacteria b3248 http://www.ensemblgenomes.org/id/b3248 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0036218 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036218 GO_function GO:0036221 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036221 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0047429 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047429 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 Gene3D 3.90.950.10 http://www.cathdb.info/version/latest/superfamily/3.90.950.10 GeneID 947753 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947753 HAMAP MF_00528 http://hamap.expasy.org/unirule/MF_00528 HOGENOM HOG000241745 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000241745&db=HOGENOM6 InParanoid P25536 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P25536 IntAct P25536 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P25536* InterPro IPR003697 http://www.ebi.ac.uk/interpro/entry/IPR003697 InterPro IPR029001 http://www.ebi.ac.uk/interpro/entry/IPR029001 KEGG_Gene ecj:JW3217 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3217 KEGG_Gene eco:b3248 http://www.genome.jp/dbget-bin/www_bget?eco:b3248 KEGG_Orthology KO:K06287 http://www.genome.jp/dbget-bin/www_bget?KO:K06287 OMA VITGYCI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VITGYCI PDB 4P0E http://www.ebi.ac.uk/pdbe-srv/view/entry/4P0E PDBsum 4P0E http://www.ebi.ac.uk/pdbsum/4P0E PSORT swissprot:YHDE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHDE_ECOLI PSORT-B swissprot:YHDE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHDE_ECOLI PSORT2 swissprot:YHDE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHDE_ECOLI Pfam PF02545 http://pfam.xfam.org/family/PF02545 Phobius swissprot:YHDE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHDE_ECOLI PhylomeDB P25536 http://phylomedb.org/?seqid=P25536 ProteinModelPortal P25536 http://www.proteinmodelportal.org/query/uniprot/P25536 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1937035 http://www.ncbi.nlm.nih.gov/pubmed/1937035 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417714 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417714 RefSeq WP_000203105 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000203105 SMR P25536 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P25536 STRING 511145.b3248 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3248&targetmode=cogs STRING COG0424 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0424&targetmode=cogs SUPFAM SSF52972 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52972 TIGRFAMs TIGR00172 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00172 UniProtKB YHDE_ECOLI http://www.uniprot.org/uniprot/YHDE_ECOLI UniProtKB-AC P25536 http://www.uniprot.org/uniprot/P25536 charge swissprot:YHDE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHDE_ECOLI eggNOG COG0424 http://eggnogapi.embl.de/nog_data/html/tree/COG0424 eggNOG ENOG4108Z03 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Z03 epestfind swissprot:YHDE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHDE_ECOLI garnier swissprot:YHDE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHDE_ECOLI helixturnhelix swissprot:YHDE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHDE_ECOLI hmoment swissprot:YHDE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHDE_ECOLI iep swissprot:YHDE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHDE_ECOLI inforesidue swissprot:YHDE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHDE_ECOLI octanol swissprot:YHDE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHDE_ECOLI pepcoil swissprot:YHDE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHDE_ECOLI pepdigest swissprot:YHDE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHDE_ECOLI pepinfo swissprot:YHDE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHDE_ECOLI pepnet swissprot:YHDE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHDE_ECOLI pepstats swissprot:YHDE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHDE_ECOLI pepwheel swissprot:YHDE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHDE_ECOLI pepwindow swissprot:YHDE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHDE_ECOLI sigcleave swissprot:YHDE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHDE_ECOLI ## Database ID URL or Descriptions # EcoGene EG40005 insE5 # FUNCTION INSE5_ECOLI Involved in the transposition of the insertion sequence IS3. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 1.10.10.60 -; 1. # InterPro IPR002514 Transposase_8 # InterPro IPR009057 Homeodomain-like # Organism INSE5_ECOLI Escherichia coli (strain K12) # PIR A64845 A64845 # Pfam PF01527 HTH_Tnp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSE5_ECOLI Transposase InsE for insertion sequence IS3E # RefSeq NP_061380 NC_002483.1 # RefSeq NP_061395 NC_002483.1 # RefSeq NP_414832 NC_000913.3 # RefSeq NP_414907 NC_000913.3 # RefSeq NP_415072 NC_000913.3 # RefSeq NP_415546 NC_000913.3 # RefSeq NP_416592 NC_000913.3 # RefSeq WP_000169527 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAE76583.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the transposase 8 family. {ECO 0000305}. # SUPFAM SSF46689 SSF46689 # eggNOG COG2963 LUCA # eggNOG ENOG41090WB Bacteria BLAST swissprot:INSE5_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSE5_ECOLI BioCyc EcoCyc:MONOMER0-4245 http://biocyc.org/getid?id=EcoCyc:MONOMER0-4245 COG COG2963 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2963 DIP DIP-60621N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-60621N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4714 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4714 EcoGene EG40005 http://www.ecogene.org/geneInfo.php?eg_id=EG40005 EnsemblBacteria AAC75149 http://www.ensemblgenomes.org/id/AAC75149 EnsemblBacteria AAC75149 http://www.ensemblgenomes.org/id/AAC75149 EnsemblBacteria BAE76583 http://www.ensemblgenomes.org/id/BAE76583 EnsemblBacteria BAE76583 http://www.ensemblgenomes.org/id/BAE76583 EnsemblBacteria BAE76583 http://www.ensemblgenomes.org/id/BAE76583 EnsemblBacteria b2088 http://www.ensemblgenomes.org/id/b2088 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 GeneID 1263530 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263530 GeneID 1263552 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263552 GeneID 944952 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944952 GeneID 945584 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945584 GeneID 945759 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945759 GeneID 946616 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946616 GeneID 946900 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946900 HOGENOM HOG000266649 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000266649&db=HOGENOM6 InterPro IPR002514 http://www.ebi.ac.uk/interpro/entry/IPR002514 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 KEGG_Gene ecj:JW5341 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5341 KEGG_Gene eco:b0298 http://www.genome.jp/dbget-bin/www_bget?eco:b0298 KEGG_Gene eco:b0373 http://www.genome.jp/dbget-bin/www_bget?eco:b0373 KEGG_Gene eco:b0540 http://www.genome.jp/dbget-bin/www_bget?eco:b0540 KEGG_Gene eco:b1027 http://www.genome.jp/dbget-bin/www_bget?eco:b1027 KEGG_Gene eco:b2088 http://www.genome.jp/dbget-bin/www_bget?eco:b2088 KEGG_Orthology KO:K07483 http://www.genome.jp/dbget-bin/www_bget?KO:K07483 PSORT swissprot:INSE5_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSE5_ECOLI PSORT-B swissprot:INSE5_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSE5_ECOLI PSORT2 swissprot:INSE5_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSE5_ECOLI Pfam PF01527 http://pfam.xfam.org/family/PF01527 Phobius swissprot:INSE5_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSE5_ECOLI ProteinModelPortal P0CF70 http://www.proteinmodelportal.org/query/uniprot/P0CF70 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_061380 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061380 RefSeq NP_061395 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061395 RefSeq NP_414832 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414832 RefSeq NP_414907 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414907 RefSeq NP_415072 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415072 RefSeq NP_415546 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415546 RefSeq NP_416592 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416592 RefSeq WP_000169527 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000169527 STRING 511145.b2088 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2088&targetmode=cogs STRING COG2963 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2963&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 UniProtKB INSE5_ECOLI http://www.uniprot.org/uniprot/INSE5_ECOLI UniProtKB-AC P0CF70 http://www.uniprot.org/uniprot/P0CF70 charge swissprot:INSE5_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSE5_ECOLI eggNOG COG2963 http://eggnogapi.embl.de/nog_data/html/tree/COG2963 eggNOG ENOG41090WB http://eggnogapi.embl.de/nog_data/html/tree/ENOG41090WB epestfind swissprot:INSE5_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSE5_ECOLI garnier swissprot:INSE5_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSE5_ECOLI helixturnhelix swissprot:INSE5_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSE5_ECOLI hmoment swissprot:INSE5_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSE5_ECOLI iep swissprot:INSE5_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSE5_ECOLI inforesidue swissprot:INSE5_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSE5_ECOLI octanol swissprot:INSE5_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSE5_ECOLI pepcoil swissprot:INSE5_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSE5_ECOLI pepdigest swissprot:INSE5_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSE5_ECOLI pepinfo swissprot:INSE5_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSE5_ECOLI pepnet swissprot:INSE5_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSE5_ECOLI pepstats swissprot:INSE5_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSE5_ECOLI pepwheel swissprot:INSE5_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSE5_ECOLI pepwindow swissprot:INSE5_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSE5_ECOLI sigcleave swissprot:INSE5_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSE5_ECOLI ## Database ID URL or Descriptions # BioGrid 4259803 14 # EcoGene EG13596 yahL # IntAct P77393 3 # Organism YAHL_ECOLI Escherichia coli (strain K12) # PATRIC 32115781 VBIEscCol129921_0333 # PIR F64759 F64759 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAHL_ECOLI Uncharacterized protein YahL # RefSeq NP_414860 NC_000913.3 # RefSeq WP_001301260 NZ_LN832404.1 BLAST swissprot:YAHL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAHL_ECOLI BioCyc ECOL316407:JW0318-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0318-MONOMER BioCyc EcoCyc:G6191-MONOMER http://biocyc.org/getid?id=EcoCyc:G6191-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB3365 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3365 EcoGene EG13596 http://www.ecogene.org/geneInfo.php?eg_id=EG13596 EnsemblBacteria AAC73429 http://www.ensemblgenomes.org/id/AAC73429 EnsemblBacteria AAC73429 http://www.ensemblgenomes.org/id/AAC73429 EnsemblBacteria BAE76109 http://www.ensemblgenomes.org/id/BAE76109 EnsemblBacteria BAE76109 http://www.ensemblgenomes.org/id/BAE76109 EnsemblBacteria BAE76109 http://www.ensemblgenomes.org/id/BAE76109 EnsemblBacteria b0326 http://www.ensemblgenomes.org/id/b0326 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 944970 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944970 HOGENOM HOG000009344 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009344&db=HOGENOM6 IntAct P77393 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77393* KEGG_Gene ecj:JW0318 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0318 KEGG_Gene eco:b0326 http://www.genome.jp/dbget-bin/www_bget?eco:b0326 OMA VRDCEWL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VRDCEWL PSORT swissprot:YAHL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAHL_ECOLI PSORT-B swissprot:YAHL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAHL_ECOLI PSORT2 swissprot:YAHL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAHL_ECOLI Phobius swissprot:YAHL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAHL_ECOLI ProteinModelPortal P77393 http://www.proteinmodelportal.org/query/uniprot/P77393 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414860 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414860 RefSeq WP_001301260 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001301260 SMR P77393 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77393 STRING 511145.b0326 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0326&targetmode=cogs UniProtKB YAHL_ECOLI http://www.uniprot.org/uniprot/YAHL_ECOLI UniProtKB-AC P77393 http://www.uniprot.org/uniprot/P77393 charge swissprot:YAHL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAHL_ECOLI epestfind swissprot:YAHL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAHL_ECOLI garnier swissprot:YAHL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAHL_ECOLI helixturnhelix swissprot:YAHL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAHL_ECOLI hmoment swissprot:YAHL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAHL_ECOLI iep swissprot:YAHL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAHL_ECOLI inforesidue swissprot:YAHL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAHL_ECOLI octanol swissprot:YAHL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAHL_ECOLI pepcoil swissprot:YAHL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAHL_ECOLI pepdigest swissprot:YAHL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAHL_ECOLI pepinfo swissprot:YAHL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAHL_ECOLI pepnet swissprot:YAHL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAHL_ECOLI pepstats swissprot:YAHL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAHL_ECOLI pepwheel swissprot:YAHL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAHL_ECOLI pepwindow swissprot:YAHL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAHL_ECOLI sigcleave swissprot:YAHL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAHL_ECOLI ## Database ID URL or Descriptions # AltName MLTD_ECOLI Murein hydrolase D # AltName MLTD_ECOLI Regulatory protein DniR # BioGrid 4261468 281 # CATALYTIC ACTIVITY MLTD_ECOLI Exolytic cleavage of the (1->4)-beta- glycosidic linkage between N-acetylmuramic acid (MurNAc) and N- acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue. # CAUTION Was originally thought to be involved in hexaheme nitrite reductase (cytochrome c552) expression. {ECO:0000305|PubMed 1663890}. # CDD cd00118 LysM; 2 # DOMAIN MLTD_ECOLI LysM domains are thought to be involved in peptidoglycan binding. # EcoGene EG10246 mltD # FUNCTION MLTD_ECOLI Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division (By similarity). {ECO 0000250}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0009279 cell outer membrane; NAS:EcoCyc. # GO_component GO:0016020 membrane; NAS:EcoliWiki. # GO_function GO:0008933 lytic transglycosylase activity; NAS:EcoliWiki. # GO_function GO:0052762 gellan lyase activity; IEA:UniProtKB-EC. # GO_function GO:0052764 exo-oligoalginate lyase activity; IEA:UniProtKB-EC. # GO_process GO:0000270 peptidoglycan metabolic process; IEA:InterPro. # GO_process GO:0051353 positive regulation of oxidoreductase activity; IMP:EcoliWiki. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 3.10.350.10 -; 2. # IntAct P0AEZ7 4 # InterPro IPR000189 Transglyc_AS # InterPro IPR008258 Transglycosylase_SLT_dom_1 # InterPro IPR018392 LysM_dom # InterPro IPR023346 Lysozyme-like_dom # KEGG_Brite ko01000 Enzymes # Organism MLTD_ECOLI Escherichia coli (strain K12) # PATRIC 32115535 VBIEscCol129921_0213 # PDB 1E0G NMR; -; A=398-445 # PIR E64745 E64745 # PROSITE PS00922 TRANSGLYCOSYLASE # PROSITE PS51257 PROKAR_LIPOPROTEIN # PROSITE PS51782 LYSM; 2 # Pfam PF01464 SLT # Pfam PF01476 LysM; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MLTD_ECOLI Membrane-bound lytic murein transglycosylase D # RefSeq NP_414747 NC_000913.3 # RefSeq WP_000644685 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA43144.1; Type=Frameshift; Positions=55, 87, 226; Evidence={ECO 0000305}; # SIMILARITY Belongs to the transglycosylase Slt family. {ECO 0000305}. # SIMILARITY Contains 2 LysM domains. {ECO:0000255|PROSITE- ProRule PRU01118}. # SMART SM00257 LysM; 2 # SUBCELLULAR LOCATION MLTD_ECOLI Cell membrane {ECO 0000305}; Lipid-anchor {ECO 0000305}. # SUPFAM SSF53955 SSF53955 # SUPFAM SSF54106 SSF54106; 2 # eggNOG COG0741 LUCA # eggNOG ENOG4105E9H Bacteria BLAST swissprot:MLTD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MLTD_ECOLI BioCyc ECOL316407:JW5018-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5018-MONOMER BioCyc EcoCyc:EG10246-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10246-MONOMER BioCyc MetaCyc:EG10246-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10246-MONOMER COG COG0741 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0741 DIP DIP-48010N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48010N DOI 10.1006/jmbi.2000.3778 http://dx.doi.org/10.1006/jmbi.2000.3778 DOI 10.1016/0378-1097(91)90355-E http://dx.doi.org/10.1016/0378-1097(91)90355-E DOI 10.1016/0968-0004(94)90201-1 http://dx.doi.org/10.1016/0968-0004(94)90201-1 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.2.n1 http://www.genome.jp/dbget-bin/www_bget?EC:4.2.2.n1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EMBL X60739 http://www.ebi.ac.uk/ena/data/view/X60739 ENZYME 4.2.2.n1 http://enzyme.expasy.org/EC/4.2.2.n1 EchoBASE EB0242 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0242 EcoGene EG10246 http://www.ecogene.org/geneInfo.php?eg_id=EG10246 EnsemblBacteria AAC73316 http://www.ensemblgenomes.org/id/AAC73316 EnsemblBacteria AAC73316 http://www.ensemblgenomes.org/id/AAC73316 EnsemblBacteria BAA77882 http://www.ensemblgenomes.org/id/BAA77882 EnsemblBacteria BAA77882 http://www.ensemblgenomes.org/id/BAA77882 EnsemblBacteria BAA77882 http://www.ensemblgenomes.org/id/BAA77882 EnsemblBacteria b0211 http://www.ensemblgenomes.org/id/b0211 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0008933 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008933 GO_function GO:0052762 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052762 GO_function GO:0052764 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052764 GO_process GO:0000270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000270 GO_process GO:0051353 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051353 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 3.10.350.10 http://www.cathdb.info/version/latest/superfamily/3.10.350.10 GeneID 945694 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945694 HOGENOM HOG000258639 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000258639&db=HOGENOM6 InParanoid P0AEZ7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEZ7 IntAct P0AEZ7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEZ7* IntEnz 4.2.2.n1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.2.n1 InterPro IPR000189 http://www.ebi.ac.uk/interpro/entry/IPR000189 InterPro IPR008258 http://www.ebi.ac.uk/interpro/entry/IPR008258 InterPro IPR018392 http://www.ebi.ac.uk/interpro/entry/IPR018392 InterPro IPR023346 http://www.ebi.ac.uk/interpro/entry/IPR023346 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5018 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5018 KEGG_Gene eco:b0211 http://www.genome.jp/dbget-bin/www_bget?eco:b0211 KEGG_Orthology KO:K08307 http://www.genome.jp/dbget-bin/www_bget?KO:K08307 OMA YNPAYNQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YNPAYNQ PDB 1E0G http://www.ebi.ac.uk/pdbe-srv/view/entry/1E0G PDBsum 1E0G http://www.ebi.ac.uk/pdbsum/1E0G PROSITE PS00922 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00922 PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PROSITE PS51782 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51782 PSORT swissprot:MLTD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MLTD_ECOLI PSORT-B swissprot:MLTD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MLTD_ECOLI PSORT2 swissprot:MLTD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MLTD_ECOLI Pfam PF01464 http://pfam.xfam.org/family/PF01464 Pfam PF01476 http://pfam.xfam.org/family/PF01476 Phobius swissprot:MLTD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MLTD_ECOLI PhylomeDB P0AEZ7 http://phylomedb.org/?seqid=P0AEZ7 ProteinModelPortal P0AEZ7 http://www.proteinmodelportal.org/query/uniprot/P0AEZ7 PubMed 10843862 http://www.ncbi.nlm.nih.gov/pubmed/10843862 PubMed 1663890 http://www.ncbi.nlm.nih.gov/pubmed/1663890 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8203016 http://www.ncbi.nlm.nih.gov/pubmed/8203016 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414747 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414747 RefSeq WP_000644685 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000644685 SMART SM00257 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00257 SMR P0AEZ7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEZ7 STRING 511145.b0211 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0211&targetmode=cogs STRING COG0741 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0741&targetmode=cogs SUPFAM SSF53955 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53955 SUPFAM SSF54106 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54106 UniProtKB MLTD_ECOLI http://www.uniprot.org/uniprot/MLTD_ECOLI UniProtKB-AC P0AEZ7 http://www.uniprot.org/uniprot/P0AEZ7 charge swissprot:MLTD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MLTD_ECOLI eggNOG COG0741 http://eggnogapi.embl.de/nog_data/html/tree/COG0741 eggNOG ENOG4105E9H http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E9H epestfind swissprot:MLTD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MLTD_ECOLI garnier swissprot:MLTD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MLTD_ECOLI helixturnhelix swissprot:MLTD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MLTD_ECOLI hmoment swissprot:MLTD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MLTD_ECOLI iep swissprot:MLTD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MLTD_ECOLI inforesidue swissprot:MLTD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MLTD_ECOLI octanol swissprot:MLTD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MLTD_ECOLI pepcoil swissprot:MLTD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MLTD_ECOLI pepdigest swissprot:MLTD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MLTD_ECOLI pepinfo swissprot:MLTD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MLTD_ECOLI pepnet swissprot:MLTD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MLTD_ECOLI pepstats swissprot:MLTD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MLTD_ECOLI pepwheel swissprot:MLTD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MLTD_ECOLI pepwindow swissprot:MLTD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MLTD_ECOLI sigcleave swissprot:MLTD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MLTD_ECOLI ## Database ID URL or Descriptions # AltName STFE_ECOLI Side tail fiber protein homolog from lambdoid prophage e14 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG11818 stfE # Gene3D 3.90.1340.10 -; 1. # InterPro IPR011083 Phage_tail_collar_dom # Organism STFE_ECOLI Escherichia coli (strain K12) # PIR B64861 B64861 # Pfam PF07484 Collar # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName STFE_ECOLI Putative uncharacterized protein StfE # SEQUENCE CAUTION Sequence=X01805; Type=Frameshift; Positions=164; Evidence={ECO 0000305}; # SIMILARITY Belongs to the tail fiber family. {ECO 0000305}. BLAST swissprot:STFE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:STFE_ECOLI BioCyc EcoCyc:G6599-MONOMER http://biocyc.org/getid?id=EcoCyc:G6599-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X01805 http://www.ebi.ac.uk/ena/data/view/X01805 EchoBASE EB1765 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1765 EcoGene EG11818 http://www.ecogene.org/geneInfo.php?eg_id=EG11818 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.90.1340.10 http://www.cathdb.info/version/latest/superfamily/3.90.1340.10 HOGENOM HOG000118659 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118659&db=HOGENOM6 InterPro IPR011083 http://www.ebi.ac.uk/interpro/entry/IPR011083 PSORT swissprot:STFE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:STFE_ECOLI PSORT-B swissprot:STFE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:STFE_ECOLI PSORT2 swissprot:STFE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:STFE_ECOLI Pfam PF07484 http://pfam.xfam.org/family/PF07484 Phobius swissprot:STFE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:STFE_ECOLI ProteinModelPortal P33227 http://www.proteinmodelportal.org/query/uniprot/P33227 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3894006 http://www.ncbi.nlm.nih.gov/pubmed/3894006 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SMR P33227 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33227 UniProtKB STFE_ECOLI http://www.uniprot.org/uniprot/STFE_ECOLI UniProtKB-AC P33227 http://www.uniprot.org/uniprot/P33227 charge swissprot:STFE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:STFE_ECOLI epestfind swissprot:STFE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:STFE_ECOLI garnier swissprot:STFE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:STFE_ECOLI helixturnhelix swissprot:STFE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:STFE_ECOLI hmoment swissprot:STFE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:STFE_ECOLI iep swissprot:STFE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:STFE_ECOLI inforesidue swissprot:STFE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:STFE_ECOLI octanol swissprot:STFE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:STFE_ECOLI pepcoil swissprot:STFE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:STFE_ECOLI pepdigest swissprot:STFE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:STFE_ECOLI pepinfo swissprot:STFE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:STFE_ECOLI pepnet swissprot:STFE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:STFE_ECOLI pepstats swissprot:STFE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:STFE_ECOLI pepwheel swissprot:STFE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:STFE_ECOLI pepwindow swissprot:STFE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:STFE_ECOLI sigcleave swissprot:STFE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:STFE_ECOLI ## Database ID URL or Descriptions # AltName DKGA_ECOLI AKR5C # BIOPHYSICOCHEMICAL PROPERTIES pH dependence Optimum pH is 7.5.; # BRENDA 1.1.1.346 2026 # BioGrid 4262381 5 # CATALYTIC ACTIVITY DKGA_ECOLI 2-dehydro-D-gluconate + NADP(+) = 2,5- didehydro-D-gluconate + NADPH. # CDD cd06660 Aldo_ket_red # EcoGene EG13015 dkgA # FUNCTION DKGA_ECOLI Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008106 alcohol dehydrogenase (NADP+) activity; IDA:EcoCyc. # GO_function GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IDA:EcoCyc. # GO_function GO:0050580 2,5-didehydrogluconate reductase activity; IEA:UniProtKB-EC. # GO_process GO:0019853 L-ascorbic acid biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0051596 methylglyoxal catabolic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.100 -; 1. # InterPro IPR001395 Aldo/ket_red/Kv-b # InterPro IPR018170 Aldo/ket_reductase_CS # InterPro IPR020471 Aldo/keto_reductase # InterPro IPR023210 NADP_OxRdtase_dom # KEGG_Brite ko01000 Enzymes # MISCELLANEOUS DKGA_ECOLI 2-keto-L-gulonic acid is a key intermediate in the production of L-ascorbic acid (vitamin C). # Organism DKGA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11732 PTHR11732 # PATRIC 32121440 VBIEscCol129921_3107 # PDB 1MZR X-ray; 2.13 A; A/B=2-275 # PIR B65088 B65088 # PRINTS PR00069 ALDKETRDTASE # PROSITE PS00062 ALDOKETO_REDUCTASE_2 # PROSITE PS00063 ALDOKETO_REDUCTASE_3 # PROSITE PS00798 ALDOKETO_REDUCTASE_1 # Pfam PF00248 Aldo_ket_red; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DKGA_ECOLI 2,5-diketo-D-gluconic acid reductase A # RefSeq NP_417485 NC_000913.3 # RefSeq WP_000013149 NZ_LN832404.1 # SIMILARITY Belongs to the aldo/keto reductase family. {ECO 0000305}. # SUBCELLULAR LOCATION DKGA_ECOLI Cytoplasm {ECO 0000250}. # SUBUNIT DKGA_ECOLI Monomer. # SUPFAM SSF51430 SSF51430 # eggNOG COG0656 LUCA # eggNOG ENOG4105CV8 Bacteria BLAST swissprot:DKGA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DKGA_ECOLI BioCyc ECOL316407:JW5499-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5499-MONOMER BioCyc EcoCyc:MONOMER0-148 http://biocyc.org/getid?id=EcoCyc:MONOMER0-148 BioCyc MetaCyc:MONOMER0-148 http://biocyc.org/getid?id=MetaCyc:MONOMER0-148 COG COG0656 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0656 DOI 10.1002/prot.20710 http://dx.doi.org/10.1002/prot.20710 DOI 10.1021/bp0101841 http://dx.doi.org/10.1021/bp0101841 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.274 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.274 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 ENZYME 1.1.1.274 http://enzyme.expasy.org/EC/1.1.1.274 EchoBASE EB2835 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2835 EcoGene EG13015 http://www.ecogene.org/geneInfo.php?eg_id=EG13015 EnsemblBacteria AAC76048 http://www.ensemblgenomes.org/id/AAC76048 EnsemblBacteria AAC76048 http://www.ensemblgenomes.org/id/AAC76048 EnsemblBacteria BAE77069 http://www.ensemblgenomes.org/id/BAE77069 EnsemblBacteria BAE77069 http://www.ensemblgenomes.org/id/BAE77069 EnsemblBacteria BAE77069 http://www.ensemblgenomes.org/id/BAE77069 EnsemblBacteria b3012 http://www.ensemblgenomes.org/id/b3012 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008106 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008106 GO_function GO:0016616 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016616 GO_function GO:0050580 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050580 GO_process GO:0019853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019853 GO_process GO:0051596 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051596 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.100 http://www.cathdb.info/version/latest/superfamily/3.20.20.100 GeneID 947495 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947495 HOGENOM HOG000250272 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000250272&db=HOGENOM6 InParanoid Q46857 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46857 IntEnz 1.1.1.274 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.274 InterPro IPR001395 http://www.ebi.ac.uk/interpro/entry/IPR001395 InterPro IPR018170 http://www.ebi.ac.uk/interpro/entry/IPR018170 InterPro IPR020471 http://www.ebi.ac.uk/interpro/entry/IPR020471 InterPro IPR023210 http://www.ebi.ac.uk/interpro/entry/IPR023210 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5499 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5499 KEGG_Gene eco:b3012 http://www.genome.jp/dbget-bin/www_bget?eco:b3012 KEGG_Orthology KO:K06221 http://www.genome.jp/dbget-bin/www_bget?KO:K06221 OMA SENFRIF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SENFRIF PANTHER PTHR11732 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11732 PDB 1MZR http://www.ebi.ac.uk/pdbe-srv/view/entry/1MZR PDBsum 1MZR http://www.ebi.ac.uk/pdbsum/1MZR PRINTS PR00069 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00069 PROSITE PS00062 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00062 PROSITE PS00063 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00063 PROSITE PS00798 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00798 PSORT swissprot:DKGA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DKGA_ECOLI PSORT-B swissprot:DKGA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DKGA_ECOLI PSORT2 swissprot:DKGA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DKGA_ECOLI Pfam PF00248 http://pfam.xfam.org/family/PF00248 Phobius swissprot:DKGA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DKGA_ECOLI PhylomeDB Q46857 http://phylomedb.org/?seqid=Q46857 ProteinModelPortal Q46857 http://www.proteinmodelportal.org/query/uniprot/Q46857 PubMed 10427017 http://www.ncbi.nlm.nih.gov/pubmed/10427017 PubMed 11934293 http://www.ncbi.nlm.nih.gov/pubmed/11934293 PubMed 16284956 http://www.ncbi.nlm.nih.gov/pubmed/16284956 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417485 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417485 RefSeq WP_000013149 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000013149 SMR Q46857 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46857 STRING 511145.b3012 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3012&targetmode=cogs STRING COG0656 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0656&targetmode=cogs SUPFAM SSF51430 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51430 UniProtKB DKGA_ECOLI http://www.uniprot.org/uniprot/DKGA_ECOLI UniProtKB-AC Q46857 http://www.uniprot.org/uniprot/Q46857 charge swissprot:DKGA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DKGA_ECOLI eggNOG COG0656 http://eggnogapi.embl.de/nog_data/html/tree/COG0656 eggNOG ENOG4105CV8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CV8 epestfind swissprot:DKGA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DKGA_ECOLI garnier swissprot:DKGA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DKGA_ECOLI helixturnhelix swissprot:DKGA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DKGA_ECOLI hmoment swissprot:DKGA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DKGA_ECOLI iep swissprot:DKGA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DKGA_ECOLI inforesidue swissprot:DKGA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DKGA_ECOLI octanol swissprot:DKGA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DKGA_ECOLI pepcoil swissprot:DKGA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DKGA_ECOLI pepdigest swissprot:DKGA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DKGA_ECOLI pepinfo swissprot:DKGA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DKGA_ECOLI pepnet swissprot:DKGA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DKGA_ECOLI pepstats swissprot:DKGA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DKGA_ECOLI pepwheel swissprot:DKGA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DKGA_ECOLI pepwindow swissprot:DKGA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DKGA_ECOLI sigcleave swissprot:DKGA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DKGA_ECOLI ## Database ID URL or Descriptions # AltName REQ2_ECOLI Antitermination protein Q homolog from lambdoid prophage Qin # BioGrid 4261260 12 # EcoGene EG13832 quuQ # FUNCTION REQ2_ECOLI Positively regulate expression of some phage genes. Bacterial host RNA polymerase modified by antitermination proteins transcribes through termination sites that otherwise prevent expression of the regulated genes (By similarity). {ECO 0000250}. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0031564 transcription antitermination; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 2.10.230.10 -; 2. # IntAct P76161 5 # InterPro IPR001305 HSP_DnaJ_Cys-rich_dom # InterPro IPR003222 Antitermntn # Organism REQ2_ECOLI Escherichia coli (strain K12) # PATRIC 32118420 VBIEscCol129921_1630 # PIR B64911 B64911 # Pfam PF03589 Antiterm; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Prophage antitermination protein Q homolog QuuQ {ECO 0000305} # RefSeq NP_416077 NC_000913.3 # RefSeq WP_001047135 NZ_LN832404.1 # SIMILARITY Belongs to the phage antitermination Q type 2 family. {ECO 0000305}. # SUPFAM SSF57938 SSF57938 # eggNOG ENOG4105HGD Bacteria # eggNOG ENOG410ZK5A LUCA BLAST swissprot:REQ2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:REQ2_ECOLI BioCyc ECOL316407:JW1551-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1551-MONOMER BioCyc EcoCyc:G6830-MONOMER http://biocyc.org/getid?id=EcoCyc:G6830-MONOMER DIP DIP-28061N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-28061N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3593 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3593 EcoGene EG13832 http://www.ecogene.org/geneInfo.php?eg_id=EG13832 EnsemblBacteria AAC74632 http://www.ensemblgenomes.org/id/AAC74632 EnsemblBacteria AAC74632 http://www.ensemblgenomes.org/id/AAC74632 EnsemblBacteria BAA15258 http://www.ensemblgenomes.org/id/BAA15258 EnsemblBacteria BAA15258 http://www.ensemblgenomes.org/id/BAA15258 EnsemblBacteria BAA15258 http://www.ensemblgenomes.org/id/BAA15258 EnsemblBacteria b1559 http://www.ensemblgenomes.org/id/b1559 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0031564 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031564 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 2.10.230.10 http://www.cathdb.info/version/latest/superfamily/2.10.230.10 GeneID 946103 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946103 HOGENOM HOG000119997 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000119997&db=HOGENOM6 IntAct P76161 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76161* InterPro IPR001305 http://www.ebi.ac.uk/interpro/entry/IPR001305 InterPro IPR003222 http://www.ebi.ac.uk/interpro/entry/IPR003222 KEGG_Gene ecj:JW1551 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1551 KEGG_Gene eco:b1559 http://www.genome.jp/dbget-bin/www_bget?eco:b1559 OMA WEKELCQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WEKELCQ PSORT swissprot:REQ2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:REQ2_ECOLI PSORT-B swissprot:REQ2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:REQ2_ECOLI PSORT2 swissprot:REQ2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:REQ2_ECOLI Pfam PF03589 http://pfam.xfam.org/family/PF03589 Phobius swissprot:REQ2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:REQ2_ECOLI ProteinModelPortal P76161 http://www.proteinmodelportal.org/query/uniprot/P76161 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416077 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416077 RefSeq WP_001047135 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001047135 SMR P76161 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76161 STRING 511145.b1559 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1559&targetmode=cogs SUPFAM SSF57938 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF57938 UniProtKB REQ2_ECOLI http://www.uniprot.org/uniprot/REQ2_ECOLI UniProtKB-AC P76161 http://www.uniprot.org/uniprot/P76161 charge swissprot:REQ2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:REQ2_ECOLI eggNOG ENOG4105HGD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105HGD eggNOG ENOG410ZK5A http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZK5A epestfind swissprot:REQ2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:REQ2_ECOLI garnier swissprot:REQ2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:REQ2_ECOLI helixturnhelix swissprot:REQ2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:REQ2_ECOLI hmoment swissprot:REQ2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:REQ2_ECOLI iep swissprot:REQ2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:REQ2_ECOLI inforesidue swissprot:REQ2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:REQ2_ECOLI octanol swissprot:REQ2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:REQ2_ECOLI pepcoil swissprot:REQ2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:REQ2_ECOLI pepdigest swissprot:REQ2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:REQ2_ECOLI pepinfo swissprot:REQ2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:REQ2_ECOLI pepnet swissprot:REQ2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:REQ2_ECOLI pepstats swissprot:REQ2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:REQ2_ECOLI pepwheel swissprot:REQ2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:REQ2_ECOLI pepwindow swissprot:REQ2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:REQ2_ECOLI sigcleave swissprot:REQ2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:REQ2_ECOLI ## Database ID URL or Descriptions # AltName DOSP_ECOLI Direct oxygen-sensing phosphodiesterase # AltName DOSP_ECOLI Ec DOS # AltName DOSP_ECOLI Heme-regulated cyclic di-GMP phosphodiesterase # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=36 uM for c-di-GMP; Note=For the EAL domain, residues 532-799. {ECO 0000269|PubMed:15995192}; # BioGrid 4259419 16 # CATALYTIC ACTIVITY Cyclic di-3',5'-guanylate + H(2)O = 5'- phosphoguanylyl(3'->5')guanosine. {ECO:0000269|PubMed 19764732}. # CDD cd01948 EAL # CDD cd01949 GGDEF # COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI 18420; # COFACTOR Name=heme; Xref=ChEBI:CHEBI 30413; # DOMAIN DOSP_ECOLI Binding of an external ligand to the heme located in the N-terminal sensory domain displaces the distal heme ligand from Met-87 to the ligand and triggers a conformational change that regulates the activity of the C-terminal catalytic domain. # DOMAIN DOSP_ECOLI The EAL domain (residues 532 to 799) is a cyclic dinucleotide di-GMP (c-di-GMP) PDE hydrolyzing c-di-GMP to 5'pGpG; it has no activity on cAMP. {ECO 0000269|PubMed 15995192}. # DOMAIN DOSP_ECOLI The heme-PAS domain (residues 1-139) forms homodimers. # ENZYME REGULATION DOSP_ECOLI Has c-di-GMP PDE activity in both Fe(2+) and Fe(3+)-bound forms; this activity is increased 6-7 fold by binding of O(2) and CO (PubMed 15995192) and NO (PubMed 17535805). Has cAMP PDE activity only when the heme is in the Fe(2+) form. cAMP PDE activity is inhibited by oxidation of the heme iron and by binding of external ligands such as CO and NO. Also strongly inhibited by etazolate hydrochloride, a selective cAMP PDE inhibitor. PDE activity is inhibited in the absence of oxygen. {ECO 0000269|PubMed 15995192, ECO 0000269|PubMed 17535805, ECO 0000269|PubMed 19764732}. # EcoGene EG13792 dosP # FUNCTION DOSP_ECOLI Heme-based oxygen sensor protein displaying phosphodiesterase (PDE) activity toward c-di-GMP in response to oxygen availability. Involved in the modulation of intracellular c-di-GMP levels, in association with DosC which catalyzes the biosynthesis of c-di-GMP (diguanylate cyclase activity). Cyclic- di-GMP is a second messenger which controls cell surface- associated traits in bacteria. Has very poor PDE activity on cAMP (PubMed 15995192) but is not active with cGMP, bis(p-nitrophenyl) phosphate or p-nitrophenyl phosphate (PubMed 11970957). Via its PDE activity on c-di-GMP, DosP regulates biofilm formation through the repression of transcription of the csgBAC operon, which encodes curli structural subunits. {ECO 0000269|PubMed 11970957, ECO 0000269|PubMed 15995192, ECO 0000269|PubMed 20553324}. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_function GO:0000155 phosphorelay sensor kinase activity; IEA:InterPro. # GO_function GO:0000287 magnesium ion binding; IMP:EcoCyc. # GO_function GO:0019826 oxygen sensor activity; IDA:CACAO. # GO_function GO:0020037 heme binding; IDA:EcoCyc. # GO_function GO:0071111 cyclic-guanylate-specific phosphodiesterase activity; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0070482 response to oxygen levels; IMP:EcoCyc. # GOslim_component GO:0005622 intracellular # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.20.20.450 -; 1. # INDUCTION DOSP_ECOLI Expressed in the late exponential growth phase and at higher levels in the stationary phase. A member of the dosCP operon. Expression is RpoS dependent and is higher at 28 degrees Celsius than at 37 degrees Celsius. {ECO 0000269|PubMed 19332833, ECO 0000269|PubMed 20553324}. # IntAct P76129 3 # InterPro IPR000014 PAS # InterPro IPR000160 GGDEF_dom # InterPro IPR000700 PAS-assoc_C # InterPro IPR001610 PAC # InterPro IPR001633 EAL_dom # InterPro IPR029787 Nucleotide_cyclase # KEGG_Brite ko01000 Enzymes # MISCELLANEOUS DOSP_ECOLI Binds O(2) with a dissociation constant of about 74 uM. # Organism DOSP_ECOLI Escherichia coli (strain K12) # PATRIC 32118272 VBIEscCol129921_1556 # PDB 1S66 X-ray; 1.80 A; L/U=8-126 # PDB 1S67 X-ray; 1.50 A; L/U=8-126 # PDB 1V9Y X-ray; 1.32 A; A/B=1-139 # PDB 1V9Z X-ray; 1.90 A; A/B=1-139 # PDB 1VB6 X-ray; 1.56 A; A/B=1-139 # PDB 4HU3 X-ray; 3.30 A; A=529-799 # PDB 4HU4 X-ray; 2.40 A; A/B=529-799 # PIR D64902 D64902 # PROSITE PS50112 PAS; 2 # PROSITE PS50113 PAC # PROSITE PS50883 EAL # PROSITE PS50887 GGDEF # PTM DOSP_ECOLI The heme distal ligand is coordinated by Met-87 in the active Fe(2+) (ferrous) form, by O(2) in the O(2)-bound form and by H(2)O in the inactive Fe(3+) (ferric) form. # Pfam PF00563 EAL # Pfam PF00990 GGDEF # Pfam PF13426 PAS_9; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DOSP_ECOLI Oxygen sensor protein DosP # RefSeq NP_416006 NC_000913.3 # SIMILARITY Contains 1 EAL domain. {ECO:0000255|PROSITE- ProRule PRU00074}. # SIMILARITY Contains 1 GGDEF domain. {ECO:0000255|PROSITE- ProRule PRU00095}. # SIMILARITY Contains 1 PAC (PAS-associated C-terminal) domain. {ECO:0000255|PROSITE-ProRule PRU00141}. # SIMILARITY Contains 2 PAS (PER-ARNT-SIM) domains. {ECO:0000255|PROSITE-ProRule PRU00140}. # SMART SM00052 EAL # SMART SM00086 PAC; 2 # SMART SM00091 PAS; 2 # SMART SM00267 GGDEF # SUBUNIT DOSP_ECOLI Homodimer (PubMed 19864414); has been previously suggested to be a homotetramer based on size exclusion chromatography (PubMed 11970957). Forms a complex with DosC. {ECO 0000269|PubMed 11970957, ECO 0000269|PubMed 15005609, ECO 0000269|PubMed 19864414}. # SUPFAM SSF141868 SSF141868 # SUPFAM SSF55073 SSF55073 # SUPFAM SSF55785 SSF55785; 2 # TIGRFAMs TIGR00229 sensory_box; 2 # TIGRFAMs TIGR00254 GGDEF # eggNOG COG2199 LUCA # eggNOG COG2200 LUCA # eggNOG COG2202 LUCA # eggNOG ENOG4105BZU Bacteria BLAST swissprot:DOSP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DOSP_ECOLI BioCyc ECOL316407:JW1484-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1484-MONOMER BioCyc EcoCyc:G6783-MONOMER http://biocyc.org/getid?id=EcoCyc:G6783-MONOMER BioCyc MetaCyc:G6783-MONOMER http://biocyc.org/getid?id=MetaCyc:G6783-MONOMER COG COG2199 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2199 COG COG2200 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2200 COG COG2202 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2202 DOI 10.1021/bi025845x http://dx.doi.org/10.1021/bi025845x DOI 10.1021/bi027359f http://dx.doi.org/10.1021/bi027359f DOI 10.1021/bi035980p http://dx.doi.org/10.1021/bi035980p DOI 10.1021/bi901409g http://dx.doi.org/10.1021/bi901409g DOI 10.1021/bi991911s http://dx.doi.org/10.1021/bi991911s DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M109.066811 http://dx.doi.org/10.1074/jbc.M109.066811 DOI 10.1074/jbc.M202738200 http://dx.doi.org/10.1074/jbc.M202738200 DOI 10.1074/jbc.M204559200 http://dx.doi.org/10.1074/jbc.M204559200 DOI 10.1074/jbc.M304408200 http://dx.doi.org/10.1074/jbc.M304408200 DOI 10.1074/jbc.M314199200 http://dx.doi.org/10.1074/jbc.M314199200 DOI 10.1074/jbc.M510701200 http://dx.doi.org/10.1074/jbc.M510701200 DOI 10.1074/jbc.M701920200 http://dx.doi.org/10.1074/jbc.M701920200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1099/mic.0.024257-0 http://dx.doi.org/10.1099/mic.0.024257-0 DOI 10.1107/S0907444902011794 http://dx.doi.org/10.1107/S0907444902011794 DOI 10.1111/j.1574-695X.2010.00702.x http://dx.doi.org/10.1111/j.1574-695X.2010.00702.x DOI 10.1111/j.1742-4658.2006.05145.x http://dx.doi.org/10.1111/j.1742-4658.2006.05145.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.187.14.4774-4781.2005 http://dx.doi.org/10.1128/JB.187.14.4774-4781.2005 DOI 10.1246/cl.2006.970 http://dx.doi.org/10.1246/cl.2006.970 EC_number EC:3.1.4.52 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.4.52 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.4.52 http://enzyme.expasy.org/EC/3.1.4.52 EchoBASE EB3553 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3553 EcoGene EG13792 http://www.ecogene.org/geneInfo.php?eg_id=EG13792 EnsemblBacteria AAC74562 http://www.ensemblgenomes.org/id/AAC74562 EnsemblBacteria AAC74562 http://www.ensemblgenomes.org/id/AAC74562 EnsemblBacteria BAA15154 http://www.ensemblgenomes.org/id/BAA15154 EnsemblBacteria BAA15154 http://www.ensemblgenomes.org/id/BAA15154 EnsemblBacteria BAA15154 http://www.ensemblgenomes.org/id/BAA15154 EnsemblBacteria b1489 http://www.ensemblgenomes.org/id/b1489 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_function GO:0000155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000155 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0019826 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019826 GO_function GO:0020037 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0020037 GO_function GO:0071111 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071111 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0070482 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070482 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.20.20.450 http://www.cathdb.info/version/latest/superfamily/3.20.20.450 GeneID 945815 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945815 HOGENOM HOG000136246 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000136246&db=HOGENOM6 InParanoid P76129 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76129 IntAct P76129 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76129* IntEnz 3.1.4.52 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.4.52 InterPro IPR000014 http://www.ebi.ac.uk/interpro/entry/IPR000014 InterPro IPR000160 http://www.ebi.ac.uk/interpro/entry/IPR000160 InterPro IPR000700 http://www.ebi.ac.uk/interpro/entry/IPR000700 InterPro IPR001610 http://www.ebi.ac.uk/interpro/entry/IPR001610 InterPro IPR001633 http://www.ebi.ac.uk/interpro/entry/IPR001633 InterPro IPR029787 http://www.ebi.ac.uk/interpro/entry/IPR029787 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1484 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1484 KEGG_Gene eco:b1489 http://www.genome.jp/dbget-bin/www_bget?eco:b1489 KEGG_Orthology KO:K13243 http://www.genome.jp/dbget-bin/www_bget?KO:K13243 KEGG_Reaction rn:R08991 http://www.genome.jp/dbget-bin/www_bget?rn:R08991 OMA CHEVERI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CHEVERI PDB 1S66 http://www.ebi.ac.uk/pdbe-srv/view/entry/1S66 PDB 1S67 http://www.ebi.ac.uk/pdbe-srv/view/entry/1S67 PDB 1V9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/1V9Y PDB 1V9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/1V9Z PDB 1VB6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1VB6 PDB 4HU3 http://www.ebi.ac.uk/pdbe-srv/view/entry/4HU3 PDB 4HU4 http://www.ebi.ac.uk/pdbe-srv/view/entry/4HU4 PDBsum 1S66 http://www.ebi.ac.uk/pdbsum/1S66 PDBsum 1S67 http://www.ebi.ac.uk/pdbsum/1S67 PDBsum 1V9Y http://www.ebi.ac.uk/pdbsum/1V9Y PDBsum 1V9Z http://www.ebi.ac.uk/pdbsum/1V9Z PDBsum 1VB6 http://www.ebi.ac.uk/pdbsum/1VB6 PDBsum 4HU3 http://www.ebi.ac.uk/pdbsum/4HU3 PDBsum 4HU4 http://www.ebi.ac.uk/pdbsum/4HU4 PROSITE PS50112 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50112 PROSITE PS50113 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50113 PROSITE PS50883 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50883 PROSITE PS50887 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50887 PSORT swissprot:DOSP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DOSP_ECOLI PSORT-B swissprot:DOSP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DOSP_ECOLI PSORT2 swissprot:DOSP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DOSP_ECOLI Pfam PF00563 http://pfam.xfam.org/family/PF00563 Pfam PF00990 http://pfam.xfam.org/family/PF00990 Pfam PF13426 http://pfam.xfam.org/family/PF13426 Phobius swissprot:DOSP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DOSP_ECOLI PhylomeDB P76129 http://phylomedb.org/?seqid=P76129 ProteinModelPortal P76129 http://www.proteinmodelportal.org/query/uniprot/P76129 PubMed 10704219 http://www.ncbi.nlm.nih.gov/pubmed/10704219 PubMed 11970957 http://www.ncbi.nlm.nih.gov/pubmed/11970957 PubMed 12080073 http://www.ncbi.nlm.nih.gov/pubmed/12080073 PubMed 12081490 http://www.ncbi.nlm.nih.gov/pubmed/12081490 PubMed 12198316 http://www.ncbi.nlm.nih.gov/pubmed/12198316 PubMed 12767236 http://www.ncbi.nlm.nih.gov/pubmed/12767236 PubMed 14551206 http://www.ncbi.nlm.nih.gov/pubmed/14551206 PubMed 14982921 http://www.ncbi.nlm.nih.gov/pubmed/14982921 PubMed 15005609 http://www.ncbi.nlm.nih.gov/pubmed/15005609 PubMed 15995192 http://www.ncbi.nlm.nih.gov/pubmed/15995192 PubMed 16418169 http://www.ncbi.nlm.nih.gov/pubmed/16418169 PubMed 16519686 http://www.ncbi.nlm.nih.gov/pubmed/16519686 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17535805 http://www.ncbi.nlm.nih.gov/pubmed/17535805 PubMed 19332833 http://www.ncbi.nlm.nih.gov/pubmed/19332833 PubMed 19764732 http://www.ncbi.nlm.nih.gov/pubmed/19764732 PubMed 19864414 http://www.ncbi.nlm.nih.gov/pubmed/19864414 PubMed 20553324 http://www.ncbi.nlm.nih.gov/pubmed/20553324 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416006 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416006 SMART SM00052 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00052 SMART SM00086 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00086 SMART SM00091 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00091 SMART SM00267 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00267 SMR P76129 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76129 STRING 511145.b1489 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1489&targetmode=cogs STRING COG2199 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2199&targetmode=cogs STRING COG2200 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2200&targetmode=cogs STRING COG2202 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2202&targetmode=cogs SUPFAM SSF141868 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF141868 SUPFAM SSF55073 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55073 SUPFAM SSF55785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55785 TIGRFAMs TIGR00229 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00229 TIGRFAMs TIGR00254 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00254 UniProtKB DOSP_ECOLI http://www.uniprot.org/uniprot/DOSP_ECOLI UniProtKB-AC P76129 http://www.uniprot.org/uniprot/P76129 charge swissprot:DOSP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DOSP_ECOLI eggNOG COG2199 http://eggnogapi.embl.de/nog_data/html/tree/COG2199 eggNOG COG2200 http://eggnogapi.embl.de/nog_data/html/tree/COG2200 eggNOG COG2202 http://eggnogapi.embl.de/nog_data/html/tree/COG2202 eggNOG ENOG4105BZU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZU epestfind swissprot:DOSP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DOSP_ECOLI garnier swissprot:DOSP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DOSP_ECOLI helixturnhelix swissprot:DOSP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DOSP_ECOLI hmoment swissprot:DOSP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DOSP_ECOLI iep swissprot:DOSP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DOSP_ECOLI inforesidue swissprot:DOSP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DOSP_ECOLI octanol swissprot:DOSP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DOSP_ECOLI pepcoil swissprot:DOSP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DOSP_ECOLI pepdigest swissprot:DOSP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DOSP_ECOLI pepinfo swissprot:DOSP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DOSP_ECOLI pepnet swissprot:DOSP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DOSP_ECOLI pepstats swissprot:DOSP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DOSP_ECOLI pepwheel swissprot:DOSP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DOSP_ECOLI pepwindow swissprot:DOSP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DOSP_ECOLI sigcleave swissprot:DOSP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DOSP_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES 6PGD_ECOLI Kinetic parameters KM=49 uM for NADP {ECO 0000269|PubMed 19686854}; KM=93 uM for 6-phospho-D-gluconate {ECO 0000269|PubMed 19686854}; # BRENDA 1.1.1.44 2026 # BioGrid 4261354 7 # CATALYTIC ACTIVITY 6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO(2) + NADPH. {ECO:0000269|PubMed 19686854}. # EcoGene EG10411 gnd # FUNCTION 6PGD_ECOLI Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. {ECO 0000269|PubMed 19686854}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity; IDA:UniProtKB. # GO_function GO:0042803 protein homodimerization activity; IPI:UniProtKB. # GO_process GO:0006098 pentose-phosphate shunt; IDA:UniProtKB. # GO_process GO:0019521 D-gluconate metabolic process; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 1.10.1040.10 -; 1. # Gene3D 1.20.5.320 -; 1. # Gene3D 3.40.50.720 -; 1. # INTERACTION 6PGD_ECOLI Self; NbExp=4; IntAct=EBI-907049, EBI-907049; # IntAct P00350 5 # InterPro IPR006113 6PGDH_Gnd/GntZ # InterPro IPR006114 6PGDH_C # InterPro IPR006115 6PGDH_NADP-bd # InterPro IPR006183 Pgluconate_DH # InterPro IPR006184 6PGdom_BS # InterPro IPR008927 6-PGluconate_DH_C-like # InterPro IPR012284 6PGD_dom_3 # InterPro IPR013328 6PGD_dom_2 # InterPro IPR016040 NAD(P)-bd_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00030 Pentose phosphate pathway # KEGG_Pathway ko00480 Glutathione metabolism # Organism 6PGD_ECOLI Escherichia coli (strain K12) # PATHWAY Carbohydrate degradation; pentose phosphate pathway; D- ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. {ECO 0000305|PubMed:19686854}. # PATRIC 32119393 VBIEscCol129921_2106 # PDB 2ZYA X-ray; 1.60 A; A/B=1-468 # PDB 2ZYD X-ray; 1.50 A; A/B=1-468 # PDB 3FWN X-ray; 1.50 A; A/B=1-468 # PIR D64968 DEECGC # PIR I62463 I62463 # PIR I62465 I62465 # PIRSF PIRSF000109 6PGD # PRINTS PR00076 6PGDHDRGNASE # PROSITE PS00461 6PGD # Pfam PF00393 6PGD # Pfam PF03446 NAD_binding_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 6PGD_ECOLI 6-phosphogluconate dehydrogenase, decarboxylating # RefSeq NP_416533 NC_000913.3 # RefSeq WP_000043484 NZ_LN832404.1 # SIMILARITY Belongs to the 6-phosphogluconate dehydrogenase family. {ECO 0000305}. # SMART SM01350 6PGD # SUBUNIT Homodimer. {ECO:0000269|PubMed 19686854}. # SUPFAM SSF48179 SSF48179 # SUPFAM SSF51735 SSF51735 # TIGRFAMs TIGR00873 gnd # UniPathway UPA00115 UER00410 # eggNOG COG0362 LUCA # eggNOG ENOG4105C7Q Bacteria BLAST swissprot:6PGD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:6PGD_ECOLI BioCyc ECOL316407:JW2011-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2011-MONOMER BioCyc EcoCyc:6PGLUCONDEHYDROG-MONOMER http://biocyc.org/getid?id=EcoCyc:6PGLUCONDEHYDROG-MONOMER BioCyc MetaCyc:6PGLUCONDEHYDROG-MONOMER http://biocyc.org/getid?id=MetaCyc:6PGLUCONDEHYDROG-MONOMER COG COG0362 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0362 COG COG1023 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1023 DIP DIP-9819N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9819N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0378-1119(84)90070-2 http://dx.doi.org/10.1016/0378-1119(84)90070-2 DOI 10.1016/j.jsb.2009.08.006 http://dx.doi.org/10.1016/j.jsb.2009.08.006 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.44 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.44 EMBL AF125322 http://www.ebi.ac.uk/ena/data/view/AF125322 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K02072 http://www.ebi.ac.uk/ena/data/view/K02072 EMBL M18956 http://www.ebi.ac.uk/ena/data/view/M18956 EMBL M18957 http://www.ebi.ac.uk/ena/data/view/M18957 EMBL M18960 http://www.ebi.ac.uk/ena/data/view/M18960 EMBL M23181 http://www.ebi.ac.uk/ena/data/view/M23181 EMBL M63821 http://www.ebi.ac.uk/ena/data/view/M63821 EMBL M64326 http://www.ebi.ac.uk/ena/data/view/M64326 EMBL M64327 http://www.ebi.ac.uk/ena/data/view/M64327 EMBL M64328 http://www.ebi.ac.uk/ena/data/view/M64328 EMBL M64329 http://www.ebi.ac.uk/ena/data/view/M64329 EMBL M64330 http://www.ebi.ac.uk/ena/data/view/M64330 EMBL M64331 http://www.ebi.ac.uk/ena/data/view/M64331 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.1.1.44 http://enzyme.expasy.org/EC/1.1.1.44 EchoBASE EB0406 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0406 EcoGene EG10411 http://www.ecogene.org/geneInfo.php?eg_id=EG10411 EnsemblBacteria AAC75090 http://www.ensemblgenomes.org/id/AAC75090 EnsemblBacteria AAC75090 http://www.ensemblgenomes.org/id/AAC75090 EnsemblBacteria BAA15869 http://www.ensemblgenomes.org/id/BAA15869 EnsemblBacteria BAA15869 http://www.ensemblgenomes.org/id/BAA15869 EnsemblBacteria BAA15869 http://www.ensemblgenomes.org/id/BAA15869 EnsemblBacteria b2029 http://www.ensemblgenomes.org/id/b2029 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004616 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004616 GO_function GO:0042803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803 GO_process GO:0006098 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006098 GO_process GO:0019521 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019521 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 1.10.1040.10 http://www.cathdb.info/version/latest/superfamily/1.10.1040.10 Gene3D 1.20.5.320 http://www.cathdb.info/version/latest/superfamily/1.20.5.320 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 946554 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946554 InParanoid P00350 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00350 IntAct P00350 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00350* IntEnz 1.1.1.44 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.44 InterPro IPR006113 http://www.ebi.ac.uk/interpro/entry/IPR006113 InterPro IPR006114 http://www.ebi.ac.uk/interpro/entry/IPR006114 InterPro IPR006115 http://www.ebi.ac.uk/interpro/entry/IPR006115 InterPro IPR006183 http://www.ebi.ac.uk/interpro/entry/IPR006183 InterPro IPR006184 http://www.ebi.ac.uk/interpro/entry/IPR006184 InterPro IPR008927 http://www.ebi.ac.uk/interpro/entry/IPR008927 InterPro IPR012284 http://www.ebi.ac.uk/interpro/entry/IPR012284 InterPro IPR013328 http://www.ebi.ac.uk/interpro/entry/IPR013328 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2011 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2011 KEGG_Gene eco:b2029 http://www.genome.jp/dbget-bin/www_bget?eco:b2029 KEGG_Orthology KO:K00033 http://www.genome.jp/dbget-bin/www_bget?KO:K00033 KEGG_Pathway ko00030 http://www.genome.jp/kegg-bin/show_pathway?ko00030 KEGG_Pathway ko00480 http://www.genome.jp/kegg-bin/show_pathway?ko00480 KEGG_Reaction rn:R01528 http://www.genome.jp/dbget-bin/www_bget?rn:R01528 OMA EGEPCVT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EGEPCVT PDB 2ZYA http://www.ebi.ac.uk/pdbe-srv/view/entry/2ZYA PDB 2ZYD http://www.ebi.ac.uk/pdbe-srv/view/entry/2ZYD PDB 3FWN http://www.ebi.ac.uk/pdbe-srv/view/entry/3FWN PDBsum 2ZYA http://www.ebi.ac.uk/pdbsum/2ZYA PDBsum 2ZYD http://www.ebi.ac.uk/pdbsum/2ZYD PDBsum 3FWN http://www.ebi.ac.uk/pdbsum/3FWN PRINTS PR00076 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00076 PROSITE PS00461 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00461 PSORT swissprot:6PGD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:6PGD_ECOLI PSORT-B swissprot:6PGD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:6PGD_ECOLI PSORT2 swissprot:6PGD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:6PGD_ECOLI Pfam PF00393 http://pfam.xfam.org/family/PF00393 Pfam PF03446 http://pfam.xfam.org/family/PF03446 Phobius swissprot:6PGD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:6PGD_ECOLI PhylomeDB P00350 http://phylomedb.org/?seqid=P00350 ProteinModelPortal P00350 http://www.proteinmodelportal.org/query/uniprot/P00350 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1938920 http://www.ncbi.nlm.nih.gov/pubmed/1938920 PubMed 19686854 http://www.ncbi.nlm.nih.gov/pubmed/19686854 PubMed 2050640 http://www.ncbi.nlm.nih.gov/pubmed/2050640 PubMed 2464736 http://www.ncbi.nlm.nih.gov/pubmed/2464736 PubMed 3275621 http://www.ncbi.nlm.nih.gov/pubmed/3275621 PubMed 6329905 http://www.ncbi.nlm.nih.gov/pubmed/6329905 PubMed 7677991 http://www.ncbi.nlm.nih.gov/pubmed/7677991 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_416533 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416533 RefSeq WP_000043484 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000043484 SMART SM01350 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01350 SMR P00350 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00350 STRING 511145.b2029 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2029&targetmode=cogs STRING COG0362 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0362&targetmode=cogs STRING COG1023 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1023&targetmode=cogs SUPFAM SSF48179 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48179 SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 TIGRFAMs TIGR00873 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00873 UniProtKB 6PGD_ECOLI http://www.uniprot.org/uniprot/6PGD_ECOLI UniProtKB-AC P00350 http://www.uniprot.org/uniprot/P00350 charge swissprot:6PGD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:6PGD_ECOLI eggNOG COG0362 http://eggnogapi.embl.de/nog_data/html/tree/COG0362 eggNOG ENOG4105C7Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C7Q epestfind swissprot:6PGD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:6PGD_ECOLI garnier swissprot:6PGD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:6PGD_ECOLI helixturnhelix swissprot:6PGD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:6PGD_ECOLI hmoment swissprot:6PGD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:6PGD_ECOLI iep swissprot:6PGD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:6PGD_ECOLI inforesidue swissprot:6PGD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:6PGD_ECOLI octanol swissprot:6PGD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:6PGD_ECOLI pepcoil swissprot:6PGD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:6PGD_ECOLI pepdigest swissprot:6PGD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:6PGD_ECOLI pepinfo swissprot:6PGD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:6PGD_ECOLI pepnet swissprot:6PGD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:6PGD_ECOLI pepstats swissprot:6PGD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:6PGD_ECOLI pepwheel swissprot:6PGD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:6PGD_ECOLI pepwindow swissprot:6PGD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:6PGD_ECOLI sigcleave swissprot:6PGD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:6PGD_ECOLI ## Database ID URL or Descriptions # BioGrid 4262411 70 # DISRUPTION PHENOTYPE YQJA_ECOLI Double mutants lacking both yghB and yqjA show incomplete cell division, temperature sensitivity and altered phospholipid levels. They are also hypersensitive to several compounds known to be exported by other drug efflux proteins, including ethidium bromide, methyl viologen, acriflavine and beta- lactam antibiotics. Expression of either yghB or yqjA can restore the wild-type phenotype, suggesting that these proteins have redundant functions. Both individual null mutant strains grow normally at all temperatures. {ECO 0000269|PubMed 18456815, ECO 0000269|PubMed 19880597, ECO 0000269|PubMed 24277026}. # EcoGene EG12740 yqjA # FUNCTION YQJA_ECOLI May be a membrane transporter required for proton motive force (PMF)-dependent drug efflux. Required, with YghB, for the proper export of certain periplasmic amidases and, possibly, other Tat substrates. May play a role in determining membrane lipid composition. {ECO 0000269|PubMed 18456815, ECO 0000269|PubMed 19880597, ECO 0000269|PubMed 24277026}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0022857 transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0043093 FtsZ-dependent cytokinesis; IGI:EcoCyc. # GO_process GO:0055085 transmembrane transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0055085 transmembrane transport # INDUCTION Regulated by the CpxA/CpxR two-component system. {ECO:0000269|PubMed 16861804}. # InterPro IPR032816 SNARE_assoc # InterPro IPR032818 DedA # Organism YQJA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30353 PTHR30353 # PATRIC 32121610 VBIEscCol129921_3191 # PIR D65098 D65098 # Pfam PF09335 SNARE_assoc # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQJA_ECOLI Inner membrane protein YqjA # RefSeq NP_417566 NC_000913.3 # RefSeq WP_000422149 NZ_LN832404.1 # SIMILARITY Belongs to the DedA family. {ECO 0000305}. # SUBCELLULAR LOCATION YQJA_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 9.B.27.2 the deda or ydjx-z (deda) family # eggNOG COG0586 LUCA # eggNOG ENOG4106W5V Bacteria BLAST swissprot:YQJA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQJA_ECOLI BioCyc ECOL316407:JW3066-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3066-MONOMER BioCyc EcoCyc:G7609-MONOMER http://biocyc.org/getid?id=EcoCyc:G7609-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AAC.02238-13 http://dx.doi.org/10.1128/AAC.02238-13 DOI 10.1128/JB.00414-08 http://dx.doi.org/10.1128/JB.00414-08 DOI 10.1128/JB.00716-09 http://dx.doi.org/10.1128/JB.00716-09 DOI 10.1271/bbb.60024 http://dx.doi.org/10.1271/bbb.60024 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D13328 http://www.ebi.ac.uk/ena/data/view/D13328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2596 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2596 EcoGene EG12740 http://www.ecogene.org/geneInfo.php?eg_id=EG12740 EnsemblBacteria AAC76130 http://www.ensemblgenomes.org/id/AAC76130 EnsemblBacteria AAC76130 http://www.ensemblgenomes.org/id/AAC76130 EnsemblBacteria BAE77145 http://www.ensemblgenomes.org/id/BAE77145 EnsemblBacteria BAE77145 http://www.ensemblgenomes.org/id/BAE77145 EnsemblBacteria BAE77145 http://www.ensemblgenomes.org/id/BAE77145 EnsemblBacteria b3095 http://www.ensemblgenomes.org/id/b3095 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GO_process GO:0043093 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043093 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 947643 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947643 HOGENOM HOG000105367 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000105367&db=HOGENOM6 InParanoid P0AA63 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AA63 InterPro IPR032816 http://www.ebi.ac.uk/interpro/entry/IPR032816 InterPro IPR032818 http://www.ebi.ac.uk/interpro/entry/IPR032818 KEGG_Gene ecj:JW3066 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3066 KEGG_Gene eco:b3095 http://www.genome.jp/dbget-bin/www_bget?eco:b3095 OMA HYHERAH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HYHERAH PANTHER PTHR30353 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30353 PSORT swissprot:YQJA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQJA_ECOLI PSORT-B swissprot:YQJA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQJA_ECOLI PSORT2 swissprot:YQJA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQJA_ECOLI Pfam PF09335 http://pfam.xfam.org/family/PF09335 Phobius swissprot:YQJA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQJA_ECOLI PhylomeDB P0AA63 http://phylomedb.org/?seqid=P0AA63 ProteinModelPortal P0AA63 http://www.proteinmodelportal.org/query/uniprot/P0AA63 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16861804 http://www.ncbi.nlm.nih.gov/pubmed/16861804 PubMed 18456815 http://www.ncbi.nlm.nih.gov/pubmed/18456815 PubMed 19880597 http://www.ncbi.nlm.nih.gov/pubmed/19880597 PubMed 24277026 http://www.ncbi.nlm.nih.gov/pubmed/24277026 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417566 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417566 RefSeq WP_000422149 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000422149 STRING 511145.b3095 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3095&targetmode=cogs TCDB 9.B.27.2 http://www.tcdb.org/search/result.php?tc=9.B.27.2 UniProtKB YQJA_ECOLI http://www.uniprot.org/uniprot/YQJA_ECOLI UniProtKB-AC P0AA63 http://www.uniprot.org/uniprot/P0AA63 charge swissprot:YQJA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQJA_ECOLI eggNOG COG0586 http://eggnogapi.embl.de/nog_data/html/tree/COG0586 eggNOG ENOG4106W5V http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106W5V epestfind swissprot:YQJA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQJA_ECOLI garnier swissprot:YQJA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQJA_ECOLI helixturnhelix swissprot:YQJA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQJA_ECOLI hmoment swissprot:YQJA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQJA_ECOLI iep swissprot:YQJA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQJA_ECOLI inforesidue swissprot:YQJA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQJA_ECOLI octanol swissprot:YQJA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQJA_ECOLI pepcoil swissprot:YQJA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQJA_ECOLI pepdigest swissprot:YQJA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQJA_ECOLI pepinfo swissprot:YQJA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQJA_ECOLI pepnet swissprot:YQJA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQJA_ECOLI pepstats swissprot:YQJA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQJA_ECOLI pepwheel swissprot:YQJA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQJA_ECOLI pepwindow swissprot:YQJA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQJA_ECOLI sigcleave swissprot:YQJA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQJA_ECOLI ## Database ID URL or Descriptions # AltName Formylglycinamide ribonucleotide amidotransferase {ECO:0000255|HAMAP-Rule MF_00419} # BIOPHYSICOCHEMICAL PROPERTIES PUR4_ECOLI Kinetic parameters KM=64 uM for glutamine (at pH 7.25 and 37 degrees Celsius) {ECO 0000269|PubMed 2659070}; KM=51 uM for ATP (at pH 7.25 and 37 degrees Celsius) {ECO 0000269|PubMed 2659070}; KM=30 uM for FGAR (formylglycinamide ribonucleotide at pH 7.25 and 37 degrees Celsius) {ECO 0000269|PubMed 2659070}; pH dependence Optimum pH is 7.2 with only 50% of this activity retains at pH 6.2 or 8.0. {ECO 0000269|PubMed 2659070}; # BioGrid 4259206 41 # CATALYTIC ACTIVITY PUR4_ECOLI ATP + N(2)-formyl-N(1)-(5-phospho-D- ribosyl)glycinamide + L-glutamine + H(2)O = ADP + phosphate + 2- (formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate. {ECO 0000255|HAMAP-Rule MF_00419, ECO 0000269|PubMed 2659070}. # EcoGene EG10797 purL # FUNCTION PUR4_ECOLI Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. {ECO 0000255|HAMAP-Rule MF_00419, ECO 0000269|PubMed 2659070}. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004642 phosphoribosylformylglycinamidine synthase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IDA:EcoliWiki. # GO_function GO:0042623 ATPase activity, coupled; IDA:EcoliWiki. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006164 purine nucleotide biosynthetic process; IBA:GO_Central. # GO_process GO:0006189 'de novo' IMP biosynthetic process; IC:EcoliWiki. # GO_process GO:0006541 glutamine metabolic process; IDA:EcoliWiki. # GO_process GO:0009156 ribonucleoside monophosphate biosynthetic process; IBA:GO_Central. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.30.1330.10 -; 2. # Gene3D 3.40.50.880 -; 1. # HAMAP MF_00419 PurL_1 # IntAct P15254 8 # InterPro IPR010073 PRibForGlyAmidine_synth # InterPro IPR010918 AIR_synth_C_dom # InterPro IPR016188 PurM-like_N # InterPro IPR017926 GATASE # InterPro IPR029062 Class_I_gatase-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # Organism PUR4_ECOLI Escherichia coli (strain K12) # PATHWAY Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5- phospho-D-ribosyl)glycinamide: step 1/2. {ECO 0000255|HAMAP- Rule:MF_00419}. # PATRIC 32120513 VBIEscCol129921_2659 # PIR D65033 SYECPG # PROSITE PS51273 GATASE_TYPE_1 # PTM PUR4_ECOLI Both N-terminus methionine truncation and retention have been observed for this protein. {ECO 0000269|PubMed 2659070}. # Pfam PF02769 AIRS_C; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Phosphoribosylformylglycinamidine synthase {ECO:0000255|HAMAP-Rule MF_00419} # RefSeq WP_000970102 NZ_LN832404.1 # RefSeq YP_026170 NC_000913.3 # SIMILARITY Contains 1 glutamine amidotransferase type-1 domain. {ECO:0000255|HAMAP-Rule MF_00419}. # SIMILARITY In the N-terminal section; belongs to the FGAMS family. {ECO:0000255|HAMAP-Rule MF_00419}. # SUBCELLULAR LOCATION PUR4_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00419, ECO 0000269|PubMed 2659070}. # SUBUNIT PUR4_ECOLI Monomer. {ECO 0000255|HAMAP-Rule MF_00419, ECO 0000269|PubMed 2659070}. # SUPFAM SSF52317 SSF52317 # SUPFAM SSF56042 SSF56042; 2 # TIGRFAMs TIGR01735 FGAM_synt # UniPathway UPA00074 UER00128 # eggNOG COG0046 LUCA # eggNOG COG0047 LUCA # eggNOG ENOG4107QIK Bacteria BLAST swissprot:PUR4_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PUR4_ECOLI BioCyc ECOL316407:JW2541-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2541-MONOMER BioCyc EcoCyc:FGAMSYN-MONOMER http://biocyc.org/getid?id=EcoCyc:FGAMSYN-MONOMER BioCyc MetaCyc:FGAMSYN-MONOMER http://biocyc.org/getid?id=MetaCyc:FGAMSYN-MONOMER COG COG0046 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0046 COG COG0047 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0047 DIP DIP-10614N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10614N DOI 10.1021/bi00432a017 http://dx.doi.org/10.1021/bi00432a017 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.3.5.3 {ECO:0000255|HAMAP-Rule:MF_00419} http://www.genome.jp/dbget-bin/www_bget?EC:6.3.5.3 {ECO:0000255|HAMAP-Rule:MF_00419} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M19501 http://www.ebi.ac.uk/ena/data/view/M19501 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36841 http://www.ebi.ac.uk/ena/data/view/U36841 ENZYME 6.3.5.3 {ECO:0000255|HAMAP-Rule:MF_00419} http://enzyme.expasy.org/EC/6.3.5.3 {ECO:0000255|HAMAP-Rule:MF_00419} EchoBASE EB0790 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0790 EcoGene EG10797 http://www.ecogene.org/geneInfo.php?eg_id=EG10797 EnsemblBacteria AAT48143 http://www.ensemblgenomes.org/id/AAT48143 EnsemblBacteria AAT48143 http://www.ensemblgenomes.org/id/AAT48143 EnsemblBacteria BAE76733 http://www.ensemblgenomes.org/id/BAE76733 EnsemblBacteria BAE76733 http://www.ensemblgenomes.org/id/BAE76733 EnsemblBacteria BAE76733 http://www.ensemblgenomes.org/id/BAE76733 EnsemblBacteria b2557 http://www.ensemblgenomes.org/id/b2557 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004642 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004642 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0042623 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042623 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006164 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006164 GO_process GO:0006189 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006189 GO_process GO:0006541 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006541 GO_process GO:0009156 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009156 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.30.1330.10 http://www.cathdb.info/version/latest/superfamily/3.30.1330.10 Gene3D 3.40.50.880 http://www.cathdb.info/version/latest/superfamily/3.40.50.880 GeneID 947032 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947032 HAMAP MF_00419 http://hamap.expasy.org/unirule/MF_00419 HOGENOM HOG000261359 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261359&db=HOGENOM6 InParanoid P15254 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P15254 IntAct P15254 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P15254* IntEnz 6.3.5.3 {ECO:0000255|HAMAP-Rule:MF_00419} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.5.3 {ECO:0000255|HAMAP-Rule:MF_00419} InterPro IPR010073 http://www.ebi.ac.uk/interpro/entry/IPR010073 InterPro IPR010918 http://www.ebi.ac.uk/interpro/entry/IPR010918 InterPro IPR016188 http://www.ebi.ac.uk/interpro/entry/IPR016188 InterPro IPR017926 http://www.ebi.ac.uk/interpro/entry/IPR017926 InterPro IPR029062 http://www.ebi.ac.uk/interpro/entry/IPR029062 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2541 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2541 KEGG_Gene eco:b2557 http://www.genome.jp/dbget-bin/www_bget?eco:b2557 KEGG_Orthology KO:K01952 http://www.genome.jp/dbget-bin/www_bget?KO:K01952 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Reaction rn:R04463 http://www.genome.jp/dbget-bin/www_bget?rn:R04463 MINT MINT-1262623 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1262623 OMA KAETHNF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KAETHNF PROSITE PS51273 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51273 PSORT swissprot:PUR4_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PUR4_ECOLI PSORT-B swissprot:PUR4_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PUR4_ECOLI PSORT2 swissprot:PUR4_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PUR4_ECOLI Pfam PF02769 http://pfam.xfam.org/family/PF02769 Phobius swissprot:PUR4_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PUR4_ECOLI PhylomeDB P15254 http://phylomedb.org/?seqid=P15254 ProteinModelPortal P15254 http://www.proteinmodelportal.org/query/uniprot/P15254 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2531746 http://www.ncbi.nlm.nih.gov/pubmed/2531746 PubMed 2659070 http://www.ncbi.nlm.nih.gov/pubmed/2659070 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000970102 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000970102 RefSeq YP_026170 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026170 SMR P15254 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P15254 STRING 511145.b2557 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2557&targetmode=cogs STRING COG0046 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0046&targetmode=cogs STRING COG0047 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0047&targetmode=cogs SUPFAM SSF52317 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52317 SUPFAM SSF56042 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56042 TIGRFAMs TIGR01735 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01735 UniProtKB PUR4_ECOLI http://www.uniprot.org/uniprot/PUR4_ECOLI UniProtKB-AC P15254 http://www.uniprot.org/uniprot/P15254 charge swissprot:PUR4_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PUR4_ECOLI eggNOG COG0046 http://eggnogapi.embl.de/nog_data/html/tree/COG0046 eggNOG COG0047 http://eggnogapi.embl.de/nog_data/html/tree/COG0047 eggNOG ENOG4107QIK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QIK epestfind swissprot:PUR4_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PUR4_ECOLI garnier swissprot:PUR4_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PUR4_ECOLI helixturnhelix swissprot:PUR4_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PUR4_ECOLI hmoment swissprot:PUR4_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PUR4_ECOLI iep swissprot:PUR4_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PUR4_ECOLI inforesidue swissprot:PUR4_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PUR4_ECOLI octanol swissprot:PUR4_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PUR4_ECOLI pepcoil swissprot:PUR4_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PUR4_ECOLI pepdigest swissprot:PUR4_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PUR4_ECOLI pepinfo swissprot:PUR4_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PUR4_ECOLI pepnet swissprot:PUR4_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PUR4_ECOLI pepstats swissprot:PUR4_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PUR4_ECOLI pepwheel swissprot:PUR4_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PUR4_ECOLI pepwindow swissprot:PUR4_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PUR4_ECOLI sigcleave swissprot:PUR4_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PUR4_ECOLI ## Database ID URL or Descriptions # EcoGene EG13747 paaY # GO_function GO:0016289 CoA hydrolase activity; IDA:EcoCyc. # GO_function GO:0016740 transferase activity; IEA:UniProtKB-KW. # GO_process GO:0010124 phenylacetate catabolic process; IEA:UniProtKB-UniPathway. # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # IntAct P77181 6 # InterPro IPR001451 Hexapep # InterPro IPR011004 Trimer_LpxA-like # InterPro IPR011974 PaaY # Organism PAAY_ECOLI Escherichia coli (strain K12) # PATHWAY PAAY_ECOLI Aromatic compound metabolism; phenylacetate degradation. # PATRIC 32118086 VBIEscCol129921_1463 # PIR C64891 C64891 # Pfam PF00132 Hexapep; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PAAY_ECOLI Phenylacetic acid degradation protein PaaY # RefSeq NP_415918 NC_000913.3 # RefSeq WP_001123464 NZ_LN832404.1 # SIMILARITY Belongs to the transferase hexapeptide repeat family. {ECO 0000305}. # SUPFAM SSF51161 SSF51161 # TIGRFAMs TIGR02287 PaaY # eggNOG COG0663 LUCA # eggNOG ENOG4108Z0R Bacteria BLAST swissprot:PAAY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PAAY_ECOLI BioCyc ECOL316407:JW1395-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1395-MONOMER BioCyc EcoCyc:G6721-MONOMER http://biocyc.org/getid?id=EcoCyc:G6721-MONOMER BioCyc MetaCyc:G6721-MONOMER http://biocyc.org/getid?id=MetaCyc:G6721-MONOMER COG COG0663 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0663 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.273.40.25974 http://dx.doi.org/10.1074/jbc.273.40.25974 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X97452 http://www.ebi.ac.uk/ena/data/view/X97452 EchoBASE EB3510 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3510 EcoGene EG13747 http://www.ecogene.org/geneInfo.php?eg_id=EG13747 EnsemblBacteria AAC74482 http://www.ensemblgenomes.org/id/AAC74482 EnsemblBacteria AAC74482 http://www.ensemblgenomes.org/id/AAC74482 EnsemblBacteria BAA15008 http://www.ensemblgenomes.org/id/BAA15008 EnsemblBacteria BAA15008 http://www.ensemblgenomes.org/id/BAA15008 EnsemblBacteria BAA15008 http://www.ensemblgenomes.org/id/BAA15008 EnsemblBacteria b1400 http://www.ensemblgenomes.org/id/b1400 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016289 GO_function GO:0016740 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016740 GO_process GO:0010124 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010124 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 945965 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945965 HOGENOM HOG000049430 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000049430&db=HOGENOM6 InParanoid P77181 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77181 IntAct P77181 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77181* InterPro IPR001451 http://www.ebi.ac.uk/interpro/entry/IPR001451 InterPro IPR011004 http://www.ebi.ac.uk/interpro/entry/IPR011004 InterPro IPR011974 http://www.ebi.ac.uk/interpro/entry/IPR011974 KEGG_Gene ecj:JW1395 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1395 KEGG_Gene eco:b1400 http://www.genome.jp/dbget-bin/www_bget?eco:b1400 KEGG_Orthology KO:K02617 http://www.genome.jp/dbget-bin/www_bget?KO:K02617 OMA IAWKTAG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IAWKTAG PSORT swissprot:PAAY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PAAY_ECOLI PSORT-B swissprot:PAAY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PAAY_ECOLI PSORT2 swissprot:PAAY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PAAY_ECOLI Pfam PF00132 http://pfam.xfam.org/family/PF00132 Phobius swissprot:PAAY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PAAY_ECOLI PhylomeDB P77181 http://phylomedb.org/?seqid=P77181 ProteinModelPortal P77181 http://www.proteinmodelportal.org/query/uniprot/P77181 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9748275 http://www.ncbi.nlm.nih.gov/pubmed/9748275 RefSeq NP_415918 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415918 RefSeq WP_001123464 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001123464 SMR P77181 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77181 STRING 511145.b1400 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1400&targetmode=cogs STRING COG0663 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0663&targetmode=cogs SUPFAM SSF51161 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51161 TIGRFAMs TIGR02287 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02287 UniProtKB PAAY_ECOLI http://www.uniprot.org/uniprot/PAAY_ECOLI UniProtKB-AC P77181 http://www.uniprot.org/uniprot/P77181 charge swissprot:PAAY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PAAY_ECOLI eggNOG COG0663 http://eggnogapi.embl.de/nog_data/html/tree/COG0663 eggNOG ENOG4108Z0R http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Z0R epestfind swissprot:PAAY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PAAY_ECOLI garnier swissprot:PAAY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PAAY_ECOLI helixturnhelix swissprot:PAAY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PAAY_ECOLI hmoment swissprot:PAAY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PAAY_ECOLI iep swissprot:PAAY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PAAY_ECOLI inforesidue swissprot:PAAY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PAAY_ECOLI octanol swissprot:PAAY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PAAY_ECOLI pepcoil swissprot:PAAY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PAAY_ECOLI pepdigest swissprot:PAAY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PAAY_ECOLI pepinfo swissprot:PAAY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PAAY_ECOLI pepnet swissprot:PAAY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PAAY_ECOLI pepstats swissprot:PAAY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PAAY_ECOLI pepwheel swissprot:PAAY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PAAY_ECOLI pepwindow swissprot:PAAY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PAAY_ECOLI sigcleave swissprot:PAAY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PAAY_ECOLI ## Database ID URL or Descriptions # AltName Regulator of RNase III activity {ECO:0000255|HAMAP-Rule MF_01205} # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=270 uM for O-acetyl-ADP-ribose {ECO 0000269|PubMed:21257746}; # BioGrid 4260690 11 # EcoGene EG13874 ymdB # FUNCTION YMDB_ECOLI Deacetylates O-acetyl-ADP ribose. Down-regulates ribonuclease 3 (RNase III) activity. Acts by interacting directly with the region of the ribonuclease that is required for dimerization/activation. {ECO 0000255|HAMAP-Rule MF_01205, ECO 0000269|PubMed 19141481, ECO 0000269|PubMed 21257746}. # GO_function GO:0001883 purine nucleoside binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008428 ribonuclease inhibitor activity; IDA:EcoCyc. # GO_function GO:0019899 enzyme binding; IPI:EcoCyc. # GO_function GO:0061463 O-acetyl-ADP-ribose deacetylase activity; IDA:EcoCyc. # GO_process GO:0032074 negative regulation of nuclease activity; IDA:EcoCyc. # GO_process GO:0042278 purine nucleoside metabolic process; IEA:UniProtKB-HAMAP. # GO_process GO:0060701 negative regulation of ribonuclease activity; IEA:UniProtKB-HAMAP. # GO_process GO:1900231 regulation of single-species biofilm formation on inanimate substrate; IMP:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0019899 enzyme binding # GOslim_function GO:0030234 enzyme regulator activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # HAMAP MF_01205 YmdB # INDUCTION Expression is induced by both entry into stationary phase, via RpoS, and cold-shock stress. {ECO:0000269|PubMed 19141481}. # IntAct P0A8D6 3 # InterPro IPR002589 Macro_dom # InterPro IPR024900 O-Ac-ADP-ribose_deAcase # Organism YMDB_ECOLI Escherichia coli (strain K12) # PATRIC 32117327 VBIEscCol129921_1086 # PDB 1SPV X-ray; 2.00 A; A=1-176 # PDB 5CB3 X-ray; 1.80 A; A=1-177 # PDB 5CB5 X-ray; 2.80 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R=1-177 # PDB 5CMS X-ray; 2.98 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R=1-177 # PIR B64847 B64847 # PROSITE PS51154 MACRO # Pfam PF01661 Macro # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName O-acetyl-ADP-ribose deacetylase {ECO:0000255|HAMAP-Rule MF_01205} # RefSeq NP_415563 NC_000913.3 # RefSeq WP_000857405 NZ_LN832404.1 # SIMILARITY Belongs to the YmdB family. {ECO 0000305}. # SIMILARITY Contains 1 Macro domain. {ECO:0000255|HAMAP- Rule MF_01205}. # SMART SM00506 A1pp # SUBUNIT YMDB_ECOLI Homodimer. Interaction with the ribonuclease decreases homodimer formation. {ECO 0000255|HAMAP-Rule MF_01205, ECO 0000269|PubMed 19141481}. # eggNOG COG2110 LUCA # eggNOG ENOG4108UVJ Bacteria BLAST swissprot:YMDB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YMDB_ECOLI BioCyc ECOL316407:JW1032-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1032-MONOMER BioCyc EcoCyc:G6550-MONOMER http://biocyc.org/getid?id=EcoCyc:G6550-MONOMER BioCyc MetaCyc:G6550-MONOMER http://biocyc.org/getid?id=MetaCyc:G6550-MONOMER DIP DIP-48222N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48222N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M110.206771 http://dx.doi.org/10.1074/jbc.M110.206771 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1101/gad.1729508 http://dx.doi.org/10.1101/gad.1729508 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.5.1.- {ECO:0000255|HAMAP-Rule:MF_01205} http://www.genome.jp/dbget-bin/www_bget?EC:3.5.1.- {ECO:0000255|HAMAP-Rule:MF_01205} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.5.1.- {ECO:0000255|HAMAP-Rule:MF_01205} http://enzyme.expasy.org/EC/3.5.1.- {ECO:0000255|HAMAP-Rule:MF_01205} EchoBASE EB3633 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3633 EcoGene EG13874 http://www.ecogene.org/geneInfo.php?eg_id=EG13874 EnsemblBacteria AAC74129 http://www.ensemblgenomes.org/id/AAC74129 EnsemblBacteria AAC74129 http://www.ensemblgenomes.org/id/AAC74129 EnsemblBacteria BAA35835 http://www.ensemblgenomes.org/id/BAA35835 EnsemblBacteria BAA35835 http://www.ensemblgenomes.org/id/BAA35835 EnsemblBacteria BAA35835 http://www.ensemblgenomes.org/id/BAA35835 EnsemblBacteria b1045 http://www.ensemblgenomes.org/id/b1045 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0001883 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001883 GO_function GO:0008428 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008428 GO_function GO:0019899 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899 GO_function GO:0061463 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061463 GO_process GO:0032074 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032074 GO_process GO:0042278 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042278 GO_process GO:0060701 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060701 GO_process GO:1900231 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1900231 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0019899 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899 GOslim_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 946987 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946987 HAMAP MF_01205 http://hamap.expasy.org/unirule/MF_01205 HOGENOM HOG000086960 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000086960&db=HOGENOM6 InParanoid P0A8D6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8D6 IntAct P0A8D6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8D6* IntEnz 3.5.1.- {ECO:0000255|HAMAP-Rule:MF_01205} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.1.- {ECO:0000255|HAMAP-Rule:MF_01205} InterPro IPR002589 http://www.ebi.ac.uk/interpro/entry/IPR002589 InterPro IPR024900 http://www.ebi.ac.uk/interpro/entry/IPR024900 KEGG_Gene ecj:JW1032 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1032 KEGG_Gene eco:b1045 http://www.genome.jp/dbget-bin/www_bget?eco:b1045 OMA LLANCYW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LLANCYW PDB 1SPV http://www.ebi.ac.uk/pdbe-srv/view/entry/1SPV PDB 5CB3 http://www.ebi.ac.uk/pdbe-srv/view/entry/5CB3 PDB 5CB5 http://www.ebi.ac.uk/pdbe-srv/view/entry/5CB5 PDB 5CMS http://www.ebi.ac.uk/pdbe-srv/view/entry/5CMS PDBsum 1SPV http://www.ebi.ac.uk/pdbsum/1SPV PDBsum 5CB3 http://www.ebi.ac.uk/pdbsum/5CB3 PDBsum 5CB5 http://www.ebi.ac.uk/pdbsum/5CB5 PDBsum 5CMS http://www.ebi.ac.uk/pdbsum/5CMS PROSITE PS51154 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51154 PSORT swissprot:YMDB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YMDB_ECOLI PSORT-B swissprot:YMDB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YMDB_ECOLI PSORT2 swissprot:YMDB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YMDB_ECOLI Pfam PF01661 http://pfam.xfam.org/family/PF01661 Phobius swissprot:YMDB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YMDB_ECOLI PhylomeDB P0A8D6 http://phylomedb.org/?seqid=P0A8D6 ProteinModelPortal P0A8D6 http://www.proteinmodelportal.org/query/uniprot/P0A8D6 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19141481 http://www.ncbi.nlm.nih.gov/pubmed/19141481 PubMed 21257746 http://www.ncbi.nlm.nih.gov/pubmed/21257746 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415563 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415563 RefSeq WP_000857405 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000857405 SMART SM00506 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00506 SMR P0A8D6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8D6 STRING 511145.b1045 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1045&targetmode=cogs UniProtKB YMDB_ECOLI http://www.uniprot.org/uniprot/YMDB_ECOLI UniProtKB-AC P0A8D6 http://www.uniprot.org/uniprot/P0A8D6 charge swissprot:YMDB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YMDB_ECOLI eggNOG COG2110 http://eggnogapi.embl.de/nog_data/html/tree/COG2110 eggNOG ENOG4108UVJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UVJ epestfind swissprot:YMDB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YMDB_ECOLI garnier swissprot:YMDB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YMDB_ECOLI helixturnhelix swissprot:YMDB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YMDB_ECOLI hmoment swissprot:YMDB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YMDB_ECOLI iep swissprot:YMDB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YMDB_ECOLI inforesidue swissprot:YMDB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YMDB_ECOLI octanol swissprot:YMDB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YMDB_ECOLI pepcoil swissprot:YMDB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YMDB_ECOLI pepdigest swissprot:YMDB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YMDB_ECOLI pepinfo swissprot:YMDB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YMDB_ECOLI pepnet swissprot:YMDB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YMDB_ECOLI pepstats swissprot:YMDB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YMDB_ECOLI pepwheel swissprot:YMDB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YMDB_ECOLI pepwindow swissprot:YMDB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YMDB_ECOLI sigcleave swissprot:YMDB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YMDB_ECOLI ## Database ID URL or Descriptions # AltName ARGA_ECOLI N-acetylglutamate synthase # BRENDA 2.3.1 2026 # BioGrid 4262306 11 # CATALYTIC ACTIVITY Acetyl-CoA + L-glutamate = CoA + N-acetyl-L- glutamate. {ECO:0000269|PubMed 16890}. # CDD cd04237 AAK_NAGS-ABP # ENZYME REGULATION Feedback inhibition by L-arginine. {ECO:0000269|PubMed 16890}. # EcoGene EG10063 argA # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function ARGA_ECOLI GO 0004042 acetyl-CoA L-glutamate N-acetyltransferase activity; IEA UniProtKB-HAMAP. # GO_function GO:0004358 glutamate N-acetyltransferase activity; IDA:EcoCyc. # GO_process GO:0006526 arginine biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.1160.10 -; 1. # Gene3D 3.40.630.30 -; 1. # HAMAP MF_01105 N_acetyl_glu_synth # IntAct P0A6C5 3 # InterPro IPR000182 GNAT_dom # InterPro IPR001048 Asp/Glu/Uridylate_kinase # InterPro IPR010167 NH2A_AcTrfase # InterPro IPR016181 Acyl_CoA_acyltransferase # InterPro IPR033719 NAGS_kin # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00330 Arginine and proline metabolism # MISCELLANEOUS The mutant strains shown below are all feedback- resistant (fbr) strains exhibiting enhanced arginine biosynthesis. {ECO:0000305|PubMed 9572954}. # Organism ARGA_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-arginine biosynthesis; N(2)- acetyl-L-ornithine from L-glutamate: step 1/4. {ECO 0000269|PubMed:16890}. # PATRIC 32121054 VBIEscCol129921_2916 # PIR A30372 XYECAA # PIRSF PIRSF000423 ArgA # PROSITE PS51186 GNAT # Pfam PF00583 Acetyltransf_1 # Pfam PF00696 AA_kinase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ARGA_ECOLI Amino-acid acetyltransferase # RefSeq NP_417295 NC_000913.3 # RefSeq WP_000237947 NZ_LN832404.1 # SIMILARITY Belongs to the acetyltransferase family. ArgA subfamily. {ECO 0000305}. # SIMILARITY Contains 1 N-acetyltransferase domain. {ECO 0000305}. # SUBCELLULAR LOCATION ARGA_ECOLI Cytoplasm {ECO 0000305|PubMed 16890}. # SUBUNIT Homohexamer. {ECO:0000305|PubMed 16890}. # SUPFAM SSF53633 SSF53633 # SUPFAM SSF55729 SSF55729 # TIGRFAMs TIGR01890 N-Ac-Glu-synth # UniPathway UPA00068 UER00106 # eggNOG COG0548 LUCA # eggNOG COG1246 LUCA # eggNOG ENOG4108EKC Bacteria BLAST swissprot:ARGA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARGA_ECOLI BioCyc ECOL316407:JW2786-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2786-MONOMER BioCyc EcoCyc:N-ACETYLTRANSFER-MONOMER http://biocyc.org/getid?id=EcoCyc:N-ACETYLTRANSFER-MONOMER BioCyc MetaCyc:N-ACETYLTRANSFER-MONOMER http://biocyc.org/getid?id=MetaCyc:N-ACETYLTRANSFER-MONOMER COG COG0548 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0548 COG COG1246 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1246 DIP DIP-48037N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48037N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/15.24.10586 http://dx.doi.org/10.1093/nar/15.24.10586 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.1 http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.1 EMBL AF008115 http://www.ebi.ac.uk/ena/data/view/AF008115 EMBL AF008116 http://www.ebi.ac.uk/ena/data/view/AF008116 EMBL AF008117 http://www.ebi.ac.uk/ena/data/view/AF008117 EMBL AF008118 http://www.ebi.ac.uk/ena/data/view/AF008118 EMBL AF008119 http://www.ebi.ac.uk/ena/data/view/AF008119 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 EMBL Y00492 http://www.ebi.ac.uk/ena/data/view/Y00492 ENZYME 2.3.1.1 http://enzyme.expasy.org/EC/2.3.1.1 EchoBASE EB0061 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0061 EcoGene EG10063 http://www.ecogene.org/geneInfo.php?eg_id=EG10063 EnsemblBacteria AAC75857 http://www.ensemblgenomes.org/id/AAC75857 EnsemblBacteria AAC75857 http://www.ensemblgenomes.org/id/AAC75857 EnsemblBacteria BAE76887 http://www.ensemblgenomes.org/id/BAE76887 EnsemblBacteria BAE76887 http://www.ensemblgenomes.org/id/BAE76887 EnsemblBacteria BAE76887 http://www.ensemblgenomes.org/id/BAE76887 EnsemblBacteria b2818 http://www.ensemblgenomes.org/id/b2818 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004042 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004042 GO_function GO:0004358 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004358 GO_process GO:0006526 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006526 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.1160.10 http://www.cathdb.info/version/latest/superfamily/3.40.1160.10 Gene3D 3.40.630.30 http://www.cathdb.info/version/latest/superfamily/3.40.630.30 GeneID 947289 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947289 HAMAP MF_01105 http://hamap.expasy.org/unirule/MF_01105 InParanoid P0A6C5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6C5 IntAct P0A6C5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6C5* IntEnz 2.3.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.1 InterPro IPR000182 http://www.ebi.ac.uk/interpro/entry/IPR000182 InterPro IPR001048 http://www.ebi.ac.uk/interpro/entry/IPR001048 InterPro IPR010167 http://www.ebi.ac.uk/interpro/entry/IPR010167 InterPro IPR016181 http://www.ebi.ac.uk/interpro/entry/IPR016181 InterPro IPR033719 http://www.ebi.ac.uk/interpro/entry/IPR033719 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2786 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2786 KEGG_Gene eco:b2818 http://www.genome.jp/dbget-bin/www_bget?eco:b2818 KEGG_Orthology KO:K14682 http://www.genome.jp/dbget-bin/www_bget?KO:K14682 KEGG_Pathway ko00330 http://www.genome.jp/kegg-bin/show_pathway?ko00330 KEGG_Reaction rn:R00259 http://www.genome.jp/dbget-bin/www_bget?rn:R00259 MINT MINT-1292378 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1292378 OMA KQALYNY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KQALYNY PROSITE PS51186 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51186 PSORT swissprot:ARGA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARGA_ECOLI PSORT-B swissprot:ARGA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARGA_ECOLI PSORT2 swissprot:ARGA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARGA_ECOLI Pfam PF00583 http://pfam.xfam.org/family/PF00583 Pfam PF00696 http://pfam.xfam.org/family/PF00696 Phobius swissprot:ARGA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARGA_ECOLI PhylomeDB P0A6C5 http://phylomedb.org/?seqid=P0A6C5 ProteinModelPortal P0A6C5 http://www.proteinmodelportal.org/query/uniprot/P0A6C5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16890 http://www.ncbi.nlm.nih.gov/pubmed/16890 PubMed 3320971 http://www.ncbi.nlm.nih.gov/pubmed/3320971 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9572954 http://www.ncbi.nlm.nih.gov/pubmed/9572954 RefSeq NP_417295 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417295 RefSeq WP_000237947 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000237947 SMR P0A6C5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6C5 STRING 511145.b2818 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2818&targetmode=cogs STRING COG0548 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0548&targetmode=cogs STRING COG1246 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1246&targetmode=cogs SUPFAM SSF53633 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53633 SUPFAM SSF55729 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55729 TIGRFAMs TIGR01890 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01890 UniProtKB ARGA_ECOLI http://www.uniprot.org/uniprot/ARGA_ECOLI UniProtKB-AC P0A6C5 http://www.uniprot.org/uniprot/P0A6C5 charge swissprot:ARGA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARGA_ECOLI eggNOG COG0548 http://eggnogapi.embl.de/nog_data/html/tree/COG0548 eggNOG COG1246 http://eggnogapi.embl.de/nog_data/html/tree/COG1246 eggNOG ENOG4108EKC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108EKC epestfind swissprot:ARGA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARGA_ECOLI garnier swissprot:ARGA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARGA_ECOLI helixturnhelix swissprot:ARGA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARGA_ECOLI hmoment swissprot:ARGA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARGA_ECOLI iep swissprot:ARGA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARGA_ECOLI inforesidue swissprot:ARGA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARGA_ECOLI octanol swissprot:ARGA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARGA_ECOLI pepcoil swissprot:ARGA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARGA_ECOLI pepdigest swissprot:ARGA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARGA_ECOLI pepinfo swissprot:ARGA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARGA_ECOLI pepnet swissprot:ARGA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARGA_ECOLI pepstats swissprot:ARGA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARGA_ECOLI pepwheel swissprot:ARGA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARGA_ECOLI pepwindow swissprot:ARGA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARGA_ECOLI sigcleave swissprot:ARGA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARGA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259266 13 # CAZy GH63 Glycoside Hydrolase Family 63 # EcoGene EG12722 ygjK # FUNCTION YGJK_ECOLI Glucoside hydrolase that cleaves the alpha-1,3- glucosidic linkage in nigerose. Has very low activity towards maltooligosaccharides, soluble starch, nigerotriose, kojibiose and trehalose. {ECO 0000269|PubMed 18586271}. # GO_function GO:0004555 alpha,alpha-trehalase activity; IBA:GO_Central. # GO_function GO:0015926 glucosidase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0005993 trehalose catabolic process; IBA:GO_Central. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009056 catabolic process # IntAct P42592 5 # InterPro IPR001661 Glyco_hydro_37 # InterPro IPR008928 6-hairpin_glycosidase-like # Organism YGJK_ECOLI Escherichia coli (strain K12) # PANTHER PTHR23403 PTHR23403; 2 # PATRIC 32121576 VBIEscCol129921_3174 # PDB 3D3I X-ray; 1.78 A; A/B=23-783 # PDB 3W7S X-ray; 1.90 A; A/B=24-783 # PDB 3W7T X-ray; 1.50 A; A/B=24-783 # PDB 3W7U X-ray; 1.99 A; A/B=24-783 # PDB 3W7W X-ray; 2.00 A; A/B=24-783 # PDB 3W7X X-ray; 2.70 A; A/B=24-783 # PDB 5CA3 X-ray; 1.80 A; A/B=24-783 # PDB 5GW7 X-ray; 2.20 A; A/B=24-783 # PIR E65096 E65096 # Pfam PF01204 Trehalase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGJK_ECOLI Glucosidase YgjK # RefSeq NP_417551 NC_000913.3 # RefSeq WP_000695487 NZ_LN832404.1 # SIMILARITY Belongs to the glycosyl hydrolase 63 family. {ECO 0000305}. # SUPFAM SSF48208 SSF48208; 2 # eggNOG ENOG4107WCA Bacteria # eggNOG ENOG410ZVE6 LUCA BLAST swissprot:YGJK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGJK_ECOLI BioCyc ECOL316407:JW3051-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3051-MONOMER BioCyc EcoCyc:G7599-MONOMER http://biocyc.org/getid?id=EcoCyc:G7599-MONOMER BioCyc MetaCyc:G7599-MONOMER http://biocyc.org/getid?id=MetaCyc:G7599-MONOMER COG CAZy: http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=CAZy: COG GH63 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=GH63 DOI 10.1016/j.jmb.2008.05.061 http://dx.doi.org/10.1016/j.jmb.2008.05.061 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.2.1.- http://www.genome.jp/dbget-bin/www_bget?EC:3.2.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 3.2.1.- http://enzyme.expasy.org/EC/3.2.1.- EchoBASE EB2581 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2581 EcoGene EG12722 http://www.ecogene.org/geneInfo.php?eg_id=EG12722 EnsemblBacteria AAC76115 http://www.ensemblgenomes.org/id/AAC76115 EnsemblBacteria AAC76115 http://www.ensemblgenomes.org/id/AAC76115 EnsemblBacteria BAE77130 http://www.ensemblgenomes.org/id/BAE77130 EnsemblBacteria BAE77130 http://www.ensemblgenomes.org/id/BAE77130 EnsemblBacteria BAE77130 http://www.ensemblgenomes.org/id/BAE77130 EnsemblBacteria b3080 http://www.ensemblgenomes.org/id/b3080 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004555 GO_function GO:0015926 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015926 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0005993 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005993 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GeneID 947596 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947596 HOGENOM HOG000281137 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000281137&db=HOGENOM6 InParanoid P42592 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P42592 IntAct P42592 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P42592* IntEnz 3.2.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.2.1 InterPro IPR001661 http://www.ebi.ac.uk/interpro/entry/IPR001661 InterPro IPR008928 http://www.ebi.ac.uk/interpro/entry/IPR008928 KEGG_Gene ecj:JW3051 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3051 KEGG_Gene eco:b3080 http://www.genome.jp/dbget-bin/www_bget?eco:b3080 KEGG_Orthology KO:K03931 http://www.genome.jp/dbget-bin/www_bget?KO:K03931 OMA WLEEMYP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WLEEMYP PANTHER PTHR23403 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23403 PDB 3D3I http://www.ebi.ac.uk/pdbe-srv/view/entry/3D3I PDB 3W7S http://www.ebi.ac.uk/pdbe-srv/view/entry/3W7S PDB 3W7T http://www.ebi.ac.uk/pdbe-srv/view/entry/3W7T PDB 3W7U http://www.ebi.ac.uk/pdbe-srv/view/entry/3W7U PDB 3W7W http://www.ebi.ac.uk/pdbe-srv/view/entry/3W7W PDB 3W7X http://www.ebi.ac.uk/pdbe-srv/view/entry/3W7X PDB 5CA3 http://www.ebi.ac.uk/pdbe-srv/view/entry/5CA3 PDB 5GW7 http://www.ebi.ac.uk/pdbe-srv/view/entry/5GW7 PDBsum 3D3I http://www.ebi.ac.uk/pdbsum/3D3I PDBsum 3W7S http://www.ebi.ac.uk/pdbsum/3W7S PDBsum 3W7T http://www.ebi.ac.uk/pdbsum/3W7T PDBsum 3W7U http://www.ebi.ac.uk/pdbsum/3W7U PDBsum 3W7W http://www.ebi.ac.uk/pdbsum/3W7W PDBsum 3W7X http://www.ebi.ac.uk/pdbsum/3W7X PDBsum 5CA3 http://www.ebi.ac.uk/pdbsum/5CA3 PDBsum 5GW7 http://www.ebi.ac.uk/pdbsum/5GW7 PSORT swissprot:YGJK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGJK_ECOLI PSORT-B swissprot:YGJK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGJK_ECOLI PSORT2 swissprot:YGJK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGJK_ECOLI Pfam PF01204 http://pfam.xfam.org/family/PF01204 Phobius swissprot:YGJK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGJK_ECOLI PhylomeDB P42592 http://phylomedb.org/?seqid=P42592 ProteinModelPortal P42592 http://www.proteinmodelportal.org/query/uniprot/P42592 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18586271 http://www.ncbi.nlm.nih.gov/pubmed/18586271 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417551 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417551 RefSeq WP_000695487 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000695487 SMR P42592 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P42592 STRING 511145.b3080 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3080&targetmode=cogs STRING CAZy: http://string-db.org/newstring_cgi/show_network_section.pl?identifier=CAZy:&targetmode=cogs STRING GH63 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=GH63&targetmode=cogs SUPFAM SSF48208 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48208 UniProtKB YGJK_ECOLI http://www.uniprot.org/uniprot/YGJK_ECOLI UniProtKB-AC P42592 http://www.uniprot.org/uniprot/P42592 charge swissprot:YGJK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGJK_ECOLI eggNOG ENOG4107WCA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107WCA eggNOG ENOG410ZVE6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZVE6 epestfind swissprot:YGJK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGJK_ECOLI garnier swissprot:YGJK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGJK_ECOLI helixturnhelix swissprot:YGJK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGJK_ECOLI hmoment swissprot:YGJK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGJK_ECOLI iep swissprot:YGJK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGJK_ECOLI inforesidue swissprot:YGJK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGJK_ECOLI octanol swissprot:YGJK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGJK_ECOLI pepcoil swissprot:YGJK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGJK_ECOLI pepdigest swissprot:YGJK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGJK_ECOLI pepinfo swissprot:YGJK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGJK_ECOLI pepnet swissprot:YGJK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGJK_ECOLI pepstats swissprot:YGJK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGJK_ECOLI pepwheel swissprot:YGJK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGJK_ECOLI pepwindow swissprot:YGJK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGJK_ECOLI sigcleave swissprot:YGJK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGJK_ECOLI ## Database ID URL or Descriptions # AltName REDF_ECOLI Protein D # FUNCTION REDF_ECOLI Acts as a repressor of transcription and as a site- specific resolvase that cleaves at the RfsF site. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_process GO:0006310 DNA recombination; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0015074 DNA integration; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.443.10 -; 1. # InterPro IPR002104 Integrase_catalytic # InterPro IPR011010 DNA_brk_join_enz # InterPro IPR013762 Integrase-like_cat # InterPro IPR016423 Resolvase_Rsv # Organism REDF_ECOLI Escherichia coli (strain K12) # PIR A24716 A24716 # PIRSF PIRSF004576 Resolvase_Rsv # Pfam PF00589 Phage_integrase # RecName REDF_ECOLI Resolvase # RefSeq NP_061423 NC_002483.1 # SEQUENCE CAUTION Sequence=AAA24900.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the 'phage' integrase family. {ECO 0000305}. # SUPFAM SSF56349 SSF56349 BLAST swissprot:REDF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:REDF_ECOLI DOI 10.1007/BF00330529 http://dx.doi.org/10.1007/BF00330529 DOI 10.1016/0022-2836(84)90086-X http://dx.doi.org/10.1016/0022-2836(84)90086-X EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL M12987 http://www.ebi.ac.uk/ena/data/view/M12987 EMBL X00594 http://www.ebi.ac.uk/ena/data/view/X00594 EMBL X03410 http://www.ebi.ac.uk/ena/data/view/X03410 EMBL X04967 http://www.ebi.ac.uk/ena/data/view/X04967 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0015074 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015074 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.443.10 http://www.cathdb.info/version/latest/superfamily/1.10.443.10 GeneID 1263556 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263556 InterPro IPR002104 http://www.ebi.ac.uk/interpro/entry/IPR002104 InterPro IPR011010 http://www.ebi.ac.uk/interpro/entry/IPR011010 InterPro IPR013762 http://www.ebi.ac.uk/interpro/entry/IPR013762 InterPro IPR016423 http://www.ebi.ac.uk/interpro/entry/IPR016423 OMA APIHHAR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=APIHHAR PSORT swissprot:REDF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:REDF_ECOLI PSORT-B swissprot:REDF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:REDF_ECOLI PSORT2 swissprot:REDF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:REDF_ECOLI Pfam PF00589 http://pfam.xfam.org/family/PF00589 Phobius swissprot:REDF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:REDF_ECOLI PhylomeDB P06615 http://phylomedb.org/?seqid=P06615 ProteinModelPortal P06615 http://www.proteinmodelportal.org/query/uniprot/P06615 PubMed 3007930 http://www.ncbi.nlm.nih.gov/pubmed/3007930 PubMed 3027661 http://www.ncbi.nlm.nih.gov/pubmed/3027661 PubMed 6327993 http://www.ncbi.nlm.nih.gov/pubmed/6327993 RefSeq NP_061423 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061423 SMR P06615 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P06615 SUPFAM SSF56349 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56349 UniProtKB REDF_ECOLI http://www.uniprot.org/uniprot/REDF_ECOLI UniProtKB-AC P06615 http://www.uniprot.org/uniprot/P06615 charge swissprot:REDF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:REDF_ECOLI epestfind swissprot:REDF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:REDF_ECOLI garnier swissprot:REDF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:REDF_ECOLI helixturnhelix swissprot:REDF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:REDF_ECOLI hmoment swissprot:REDF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:REDF_ECOLI iep swissprot:REDF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:REDF_ECOLI inforesidue swissprot:REDF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:REDF_ECOLI octanol swissprot:REDF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:REDF_ECOLI pepcoil swissprot:REDF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:REDF_ECOLI pepdigest swissprot:REDF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:REDF_ECOLI pepinfo swissprot:REDF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:REDF_ECOLI pepnet swissprot:REDF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:REDF_ECOLI pepstats swissprot:REDF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:REDF_ECOLI pepwheel swissprot:REDF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:REDF_ECOLI pepwindow swissprot:REDF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:REDF_ECOLI sigcleave swissprot:REDF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:REDF_ECOLI ## Database ID URL or Descriptions # AltName UXAC_ECOLI Glucuronate isomerase # AltName UXAC_ECOLI Uronic isomerase # BRENDA 5.3.1.12 2026 # BioGrid 4262408 17 # CATALYTIC ACTIVITY UXAC_ECOLI D-galacturonate = D-tagaturonate. # CATALYTIC ACTIVITY UXAC_ECOLI D-glucuronate = D-fructuronate. # EcoGene EG12737 uxaC # GO_function GO:0008880 glucuronate isomerase activity; IEA:UniProtKB-HAMAP. # GO_process GO:0019698 D-galacturonate catabolic process; IMP:EcoCyc. # GO_process GO:0042840 D-glucuronate catabolic process; IDA:EcoCyc. # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.2020.10 -; 1. # HAMAP MF_00675 UxaC # INDUCTION Repressed by LeuO and H-NS. Part of the uxaCA operon. {ECO:0000269|PubMed 19429622}. # IntAct P0A8G3 9 # InterPro IPR003766 Uronate_isomerase # InterPro IPR023177 Uronate_isomerase_dom2 # InterPro IPR032466 Metal_Hydrolase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00040 Pentose and glucuronate interconversions # Organism UXAC_ECOLI Escherichia coli (strain K12) # PATHWAY UXAC_ECOLI Carbohydrate metabolism; pentose and glucuronate interconversion. # PATRIC 32121602 VBIEscCol129921_3187 # PIR A65098 A65098 # Pfam PF02614 UxaC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UXAC_ECOLI Uronate isomerase # RefSeq NP_417563 NC_000913.3 # RefSeq WP_000187442 NZ_LN832404.1 # SIMILARITY Belongs to the uronate isomerase family. {ECO 0000305}. # SUPFAM SSF51556 SSF51556 # eggNOG COG1904 LUCA # eggNOG ENOG4105D2H Bacteria BLAST swissprot:UXAC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UXAC_ECOLI BioCyc ECOL316407:JW3063-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3063-MONOMER BioCyc EcoCyc:UXAC-MONOMER http://biocyc.org/getid?id=EcoCyc:UXAC-MONOMER BioCyc MetaCyc:UXAC-MONOMER http://biocyc.org/getid?id=MetaCyc:UXAC-MONOMER COG COG1904 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1904 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00108-09 http://dx.doi.org/10.1128/JB.00108-09 EC_number EC:5.3.1.12 http://www.genome.jp/dbget-bin/www_bget?EC:5.3.1.12 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D13328 http://www.ebi.ac.uk/ena/data/view/D13328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 5.3.1.12 http://enzyme.expasy.org/EC/5.3.1.12 EchoBASE EB2593 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2593 EcoGene EG12737 http://www.ecogene.org/geneInfo.php?eg_id=EG12737 EnsemblBacteria AAC76127 http://www.ensemblgenomes.org/id/AAC76127 EnsemblBacteria AAC76127 http://www.ensemblgenomes.org/id/AAC76127 EnsemblBacteria BAE77142 http://www.ensemblgenomes.org/id/BAE77142 EnsemblBacteria BAE77142 http://www.ensemblgenomes.org/id/BAE77142 EnsemblBacteria BAE77142 http://www.ensemblgenomes.org/id/BAE77142 EnsemblBacteria b3092 http://www.ensemblgenomes.org/id/b3092 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008880 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008880 GO_process GO:0019698 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019698 GO_process GO:0042840 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042840 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.2020.10 http://www.cathdb.info/version/latest/superfamily/1.10.2020.10 GeneID 947599 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947599 HAMAP MF_00675 http://hamap.expasy.org/unirule/MF_00675 InParanoid P0A8G3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8G3 IntAct P0A8G3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8G3* IntEnz 5.3.1.12 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.3.1.12 InterPro IPR003766 http://www.ebi.ac.uk/interpro/entry/IPR003766 InterPro IPR023177 http://www.ebi.ac.uk/interpro/entry/IPR023177 InterPro IPR032466 http://www.ebi.ac.uk/interpro/entry/IPR032466 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3063 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3063 KEGG_Gene eco:b3092 http://www.genome.jp/dbget-bin/www_bget?eco:b3092 KEGG_Orthology KO:K01812 http://www.genome.jp/dbget-bin/www_bget?KO:K01812 KEGG_Pathway ko00040 http://www.genome.jp/kegg-bin/show_pathway?ko00040 KEGG_Reaction rn:R01482 http://www.genome.jp/dbget-bin/www_bget?rn:R01482 KEGG_Reaction rn:R01983 http://www.genome.jp/dbget-bin/www_bget?rn:R01983 OMA REMTTET http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=REMTTET PSORT swissprot:UXAC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UXAC_ECOLI PSORT-B swissprot:UXAC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UXAC_ECOLI PSORT2 swissprot:UXAC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UXAC_ECOLI Pfam PF02614 http://pfam.xfam.org/family/PF02614 Phobius swissprot:UXAC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UXAC_ECOLI PhylomeDB P0A8G3 http://phylomedb.org/?seqid=P0A8G3 ProteinModelPortal P0A8G3 http://www.proteinmodelportal.org/query/uniprot/P0A8G3 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19429622 http://www.ncbi.nlm.nih.gov/pubmed/19429622 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417563 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417563 RefSeq WP_000187442 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000187442 SMR P0A8G3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8G3 STRING 511145.b3092 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3092&targetmode=cogs STRING COG1904 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1904&targetmode=cogs SUPFAM SSF51556 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51556 UniProtKB UXAC_ECOLI http://www.uniprot.org/uniprot/UXAC_ECOLI UniProtKB-AC P0A8G3 http://www.uniprot.org/uniprot/P0A8G3 charge swissprot:UXAC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UXAC_ECOLI eggNOG COG1904 http://eggnogapi.embl.de/nog_data/html/tree/COG1904 eggNOG ENOG4105D2H http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D2H epestfind swissprot:UXAC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UXAC_ECOLI garnier swissprot:UXAC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UXAC_ECOLI helixturnhelix swissprot:UXAC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UXAC_ECOLI hmoment swissprot:UXAC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UXAC_ECOLI iep swissprot:UXAC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UXAC_ECOLI inforesidue swissprot:UXAC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UXAC_ECOLI octanol swissprot:UXAC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UXAC_ECOLI pepcoil swissprot:UXAC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UXAC_ECOLI pepdigest swissprot:UXAC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UXAC_ECOLI pepinfo swissprot:UXAC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UXAC_ECOLI pepnet swissprot:UXAC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UXAC_ECOLI pepstats swissprot:UXAC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UXAC_ECOLI pepwheel swissprot:UXAC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UXAC_ECOLI pepwindow swissprot:UXAC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UXAC_ECOLI sigcleave swissprot:UXAC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UXAC_ECOLI ## Database ID URL or Descriptions # BioGrid 4261611 20 # EcoGene EG13037 ygeG # GO_process GO:0006950 response to stress; IEA:InterPro. # GOslim_process GO:0006950 response to stress # Gene3D 1.25.40.10 -; 1. # InterPro IPR005415 T3SS_Ca_resp_chp_LcrH/SycD # InterPro IPR011716 TPR-3 # InterPro IPR011990 TPR-like_helical_dom # InterPro IPR016379 T3SS_Ca_resp_chp_LcrH/SycD_sub # Organism YGEG_ECOLI Escherichia coli (strain K12) # PATRIC 32121118 VBIEscCol129921_2948 # PIR D65068 D65068 # PIRSF PIRSF003165 Chaperone_SicA # PRINTS PR01595 SYCDCHAPRONE # Pfam PF07720 TPR_3; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGEG_ECOLI Uncharacterized protein YgeG # RefSeq NP_417328 NC_000913.3 # RefSeq WP_000102780 NZ_LN832404.1 # SIMILARITY Belongs to the LcrH/SycD chaperone family. {ECO 0000305}. # SUPFAM SSF48452 SSF48452 # eggNOG COG0457 LUCA BLAST swissprot:YGEG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGEG_ECOLI BioCyc ECOL316407:JW2819-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2819-MONOMER BioCyc EcoCyc:G7471-MONOMER http://biocyc.org/getid?id=EcoCyc:G7471-MONOMER DIP DIP-12150N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12150N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 EchoBASE EB2852 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2852 EcoGene EG13037 http://www.ecogene.org/geneInfo.php?eg_id=EG13037 EnsemblBacteria AAC75890 http://www.ensemblgenomes.org/id/AAC75890 EnsemblBacteria AAC75890 http://www.ensemblgenomes.org/id/AAC75890 EnsemblBacteria BAE76920 http://www.ensemblgenomes.org/id/BAE76920 EnsemblBacteria BAE76920 http://www.ensemblgenomes.org/id/BAE76920 EnsemblBacteria BAE76920 http://www.ensemblgenomes.org/id/BAE76920 EnsemblBacteria b2851 http://www.ensemblgenomes.org/id/b2851 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 1.25.40.10 http://www.cathdb.info/version/latest/superfamily/1.25.40.10 GeneID 946986 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946986 HOGENOM HOG000219447 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219447&db=HOGENOM6 InParanoid Q46787 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46787 IntAct Q46787 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46787* InterPro IPR005415 http://www.ebi.ac.uk/interpro/entry/IPR005415 InterPro IPR011716 http://www.ebi.ac.uk/interpro/entry/IPR011716 InterPro IPR011990 http://www.ebi.ac.uk/interpro/entry/IPR011990 InterPro IPR016379 http://www.ebi.ac.uk/interpro/entry/IPR016379 KEGG_Gene ecj:JW2819 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2819 KEGG_Gene eco:b2851 http://www.genome.jp/dbget-bin/www_bget?eco:b2851 MINT MINT-1288297 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1288297 OMA ENHEYLE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ENHEYLE PRINTS PR01595 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01595 PSORT swissprot:YGEG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGEG_ECOLI PSORT-B swissprot:YGEG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGEG_ECOLI PSORT2 swissprot:YGEG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGEG_ECOLI Pfam PF07720 http://pfam.xfam.org/family/PF07720 Phobius swissprot:YGEG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGEG_ECOLI ProteinModelPortal Q46787 http://www.proteinmodelportal.org/query/uniprot/Q46787 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417328 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417328 RefSeq WP_000102780 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000102780 SMR Q46787 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46787 STRING 511145.b2851 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2851&targetmode=cogs SUPFAM SSF48452 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48452 UniProtKB YGEG_ECOLI http://www.uniprot.org/uniprot/YGEG_ECOLI UniProtKB-AC Q46787 http://www.uniprot.org/uniprot/Q46787 charge swissprot:YGEG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGEG_ECOLI eggNOG COG0457 http://eggnogapi.embl.de/nog_data/html/tree/COG0457 epestfind swissprot:YGEG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGEG_ECOLI garnier swissprot:YGEG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGEG_ECOLI helixturnhelix swissprot:YGEG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGEG_ECOLI hmoment swissprot:YGEG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGEG_ECOLI iep swissprot:YGEG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGEG_ECOLI inforesidue swissprot:YGEG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGEG_ECOLI octanol swissprot:YGEG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGEG_ECOLI pepcoil swissprot:YGEG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGEG_ECOLI pepdigest swissprot:YGEG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGEG_ECOLI pepinfo swissprot:YGEG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGEG_ECOLI pepnet swissprot:YGEG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGEG_ECOLI pepstats swissprot:YGEG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGEG_ECOLI pepwheel swissprot:YGEG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGEG_ECOLI pepwindow swissprot:YGEG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGEG_ECOLI sigcleave swissprot:YGEG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGEG_ECOLI ## Database ID URL or Descriptions # AltName Peptidoglycan lytic endotransglycosylase {ECO:0000255|HAMAP-Rule MF_01381} # BRENDA 4.2.2.B6 2026 # BioGrid 4259642 360 # CATALYTIC ACTIVITY Endolytic cleavage of the (1->4)-beta- glycosidic linkage between N-acetylmuramic acid (MurNAc) and N- acetylglucosamine (GlcNAc) residues in peptidoglycan with concomitant formation of a 1,6-anhydrobond in the MurNAc residue. {ECO:0000255|HAMAP-Rule MF_01381}. # CAZy GH23 Glycoside Hydrolase Family 23 # EcoGene EG13897 emtA # FUNCTION EMTA_ECOLI Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Preferentially cleaves at a distance of more than two disaccharide units from the ends of the glycan chain. Prefers cross-linked murein in vivo. # GO_component GO:0009279 cell outer membrane; IEA:UniProtKB-SubCell. # GO_function GO:0008932 lytic endotransglycosylase activity; IDA:EcoCyc. # GO_function GO:0052762 gellan lyase activity; IEA:UniProtKB-EC. # GO_function GO:0052764 exo-oligoalginate lyase activity; IEA:UniProtKB-EC. # GO_process GO:0009254 peptidoglycan turnover; IDA:EcoCyc. # GO_process GO:0016998 cell wall macromolecule catabolic process; IEA:UniProtKB-HAMAP. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0071554 cell wall organization or biogenesis # HAMAP MF_01381 EmtA # IntAct P0C960 2 # InterPro IPR000189 Transglyc_AS # InterPro IPR008258 Transglycosylase_SLT_dom_1 # InterPro IPR023346 Lysozyme-like_dom # InterPro IPR023946 EmtA # KEGG_Brite ko01000 Enzymes # Organism EMTA_ECOLI Escherichia coli (strain K12) # PATRIC 32117634 VBIEscCol129921_1239 # PDB 2Y8P X-ray; 2.00 A; A/B=19-203 # PDB 3T36 X-ray; 2.25 A; A/B/C/D/E=17-203 # PDB 4HJV X-ray; 2.30 A; A/B/C/D/E=17-203 # PDB 4HJY X-ray; 2.40 A; A/B=17-203 # PDB 4HJZ X-ray; 1.90 A; A/B=17-203 # PIR F64865 F64865 # PROSITE PS00922 TRANSGLYCOSYLASE # PROSITE PS51257 PROKAR_LIPOPROTEIN # PTM EMTA_ECOLI The N-terminus is blocked. # Pfam PF01464 SLT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Endo-type membrane-bound lytic murein transglycosylase A {ECO:0000255|HAMAP-Rule MF_01381} # RefSeq NP_415711 NC_000913.3 # RefSeq WP_001301104 NZ_LN832404.1 # SIMILARITY Belongs to the transglycosylase Slt family. {ECO:0000255|HAMAP-Rule MF_01381}. # SUBCELLULAR LOCATION EMTA_ECOLI Cell outer membrane {ECO 0000305|PubMed 9642199}; Lipid-anchor {ECO 0000305|PubMed 9642199}. # SUPFAM SSF53955 SSF53955 # eggNOG COG0741 LUCA # eggNOG ENOG4106S48 Bacteria BLAST swissprot:EMTA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EMTA_ECOLI BioCyc EcoCyc:G6622-MONOMER http://biocyc.org/getid?id=EcoCyc:G6622-MONOMER BioCyc MetaCyc:G6622-MONOMER http://biocyc.org/getid?id=MetaCyc:G6622-MONOMER COG COG0741 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0741 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.2.n2 {ECO:0000255|HAMAP-Rule:MF_01381} http://www.genome.jp/dbget-bin/www_bget?EC:4.2.2.n2 {ECO:0000255|HAMAP-Rule:MF_01381} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 4.2.2.n2 {ECO:0000255|HAMAP-Rule:MF_01381} http://enzyme.expasy.org/EC/4.2.2.n2 {ECO:0000255|HAMAP-Rule:MF_01381} EchoBASE EB3656 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3656 EcoGene EG13897 http://www.ecogene.org/geneInfo.php?eg_id=EG13897 EnsemblBacteria AAC74277 http://www.ensemblgenomes.org/id/AAC74277 EnsemblBacteria AAC74277 http://www.ensemblgenomes.org/id/AAC74277 EnsemblBacteria BAA36051 http://www.ensemblgenomes.org/id/BAA36051 EnsemblBacteria BAA36051 http://www.ensemblgenomes.org/id/BAA36051 EnsemblBacteria BAA36051 http://www.ensemblgenomes.org/id/BAA36051 EnsemblBacteria b1193 http://www.ensemblgenomes.org/id/b1193 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_function GO:0008932 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008932 GO_function GO:0052762 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052762 GO_function GO:0052764 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052764 GO_process GO:0009254 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009254 GO_process GO:0016998 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016998 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 GeneID 945655 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945655 HAMAP MF_01381 http://hamap.expasy.org/unirule/MF_01381 HOGENOM HOG000219318 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219318&db=HOGENOM6 IntAct P0C960 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0C960* IntEnz 4.2.2.n2 {ECO:0000255|HAMAP-Rule:MF_01381} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.2.n2 {ECO:0000255|HAMAP-Rule:MF_01381} InterPro IPR000189 http://www.ebi.ac.uk/interpro/entry/IPR000189 InterPro IPR008258 http://www.ebi.ac.uk/interpro/entry/IPR008258 InterPro IPR023346 http://www.ebi.ac.uk/interpro/entry/IPR023346 InterPro IPR023946 http://www.ebi.ac.uk/interpro/entry/IPR023946 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5821 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5821 KEGG_Gene eco:b1193 http://www.genome.jp/dbget-bin/www_bget?eco:b1193 KEGG_Orthology KO:K08308 http://www.genome.jp/dbget-bin/www_bget?KO:K08308 OMA PQAPRYL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PQAPRYL PDB 2Y8P http://www.ebi.ac.uk/pdbe-srv/view/entry/2Y8P PDB 3T36 http://www.ebi.ac.uk/pdbe-srv/view/entry/3T36 PDB 4HJV http://www.ebi.ac.uk/pdbe-srv/view/entry/4HJV PDB 4HJY http://www.ebi.ac.uk/pdbe-srv/view/entry/4HJY PDB 4HJZ http://www.ebi.ac.uk/pdbe-srv/view/entry/4HJZ PDBsum 2Y8P http://www.ebi.ac.uk/pdbsum/2Y8P PDBsum 3T36 http://www.ebi.ac.uk/pdbsum/3T36 PDBsum 4HJV http://www.ebi.ac.uk/pdbsum/4HJV PDBsum 4HJY http://www.ebi.ac.uk/pdbsum/4HJY PDBsum 4HJZ http://www.ebi.ac.uk/pdbsum/4HJZ PROSITE PS00922 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00922 PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:EMTA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EMTA_ECOLI PSORT-B swissprot:EMTA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EMTA_ECOLI PSORT2 swissprot:EMTA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EMTA_ECOLI Pfam PF01464 http://pfam.xfam.org/family/PF01464 Phobius swissprot:EMTA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EMTA_ECOLI ProteinModelPortal P0C960 http://www.proteinmodelportal.org/query/uniprot/P0C960 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9642199 http://www.ncbi.nlm.nih.gov/pubmed/9642199 RefSeq NP_415711 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415711 RefSeq WP_001301104 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001301104 SMR P0C960 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0C960 STRING 511145.b1193 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1193&targetmode=cogs STRING COG0741 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0741&targetmode=cogs SUPFAM SSF53955 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53955 UniProtKB EMTA_ECOLI http://www.uniprot.org/uniprot/EMTA_ECOLI UniProtKB-AC P0C960 http://www.uniprot.org/uniprot/P0C960 charge swissprot:EMTA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EMTA_ECOLI eggNOG COG0741 http://eggnogapi.embl.de/nog_data/html/tree/COG0741 eggNOG ENOG4106S48 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106S48 epestfind swissprot:EMTA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EMTA_ECOLI garnier swissprot:EMTA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EMTA_ECOLI helixturnhelix swissprot:EMTA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EMTA_ECOLI hmoment swissprot:EMTA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EMTA_ECOLI iep swissprot:EMTA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EMTA_ECOLI inforesidue swissprot:EMTA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EMTA_ECOLI octanol swissprot:EMTA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EMTA_ECOLI pepcoil swissprot:EMTA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EMTA_ECOLI pepdigest swissprot:EMTA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EMTA_ECOLI pepinfo swissprot:EMTA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EMTA_ECOLI pepnet swissprot:EMTA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EMTA_ECOLI pepstats swissprot:EMTA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EMTA_ECOLI pepwheel swissprot:EMTA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EMTA_ECOLI pepwindow swissprot:EMTA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EMTA_ECOLI sigcleave swissprot:EMTA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EMTA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259894 9 # EcoGene EG12683 uspG # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_function GO:0004017 adenylate kinase activity; IDA:EcoliWiki. # GO_process GO:0006950 response to stress; IEA:InterPro. # GO_process GO:0018117 protein adenylylation; IDA:EcoliWiki. # GO_process GO:0046777 protein autophosphorylation; IDA:EcoliWiki. # GO_process GO:2000145 regulation of cell motility; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016301 kinase activity # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.620 -; 1. # INDUCTION By starvation, heat shock and in response to some toxic agents. {ECO:0000269|PubMed 12071968}. # INTERACTION USPG_ECOLI P0A6F5 groL; NbExp=4; IntAct=EBI-561722, EBI-543750; # IntAct P39177 78 # InterPro IPR006015 Universal_stress_UspA # InterPro IPR006016 UspA # InterPro IPR014729 Rossmann-like_a/b/a_fold # Organism USPG_ECOLI Escherichia coli (strain K12) # PATRIC 32116394 VBIEscCol129921_0637 # PIR E64794 E64794 # PRINTS PR01438 UNVRSLSTRESS # Pfam PF00582 Usp # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName USPG_ECOLI Universal stress protein G # RefSeq NP_415140 NC_000913.3 # RefSeq WP_000278509 NZ_LN832404.1 # SIMILARITY Belongs to the universal stress protein A family. {ECO 0000305}. # SUBUNIT Interacts with GroEL. {ECO:0000269|PubMed 12071968}. # eggNOG COG0589 LUCA # eggNOG ENOG4108U51 Bacteria BLAST swissprot:USPG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:USPG_ECOLI BioCyc ECOL316407:JW0600-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0600-MONOMER BioCyc EcoCyc:G6334-MONOMER http://biocyc.org/getid?id=EcoCyc:G6334-MONOMER COG COG0589 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0589 DIP DIP-11354N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11354N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1998.1726 http://dx.doi.org/10.1006/jmbi.1998.1726 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2002.02720.x http://dx.doi.org/10.1046/j.1365-2958.2002.02720.x DOI 10.1046/j.1432-1033.2002.02978.x http://dx.doi.org/10.1046/j.1432-1033.2002.02978.x DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB2547 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2547 EcoGene EG12683 http://www.ecogene.org/geneInfo.php?eg_id=EG12683 EnsemblBacteria AAC73708 http://www.ensemblgenomes.org/id/AAC73708 EnsemblBacteria AAC73708 http://www.ensemblgenomes.org/id/AAC73708 EnsemblBacteria BAA35237 http://www.ensemblgenomes.org/id/BAA35237 EnsemblBacteria BAA35237 http://www.ensemblgenomes.org/id/BAA35237 EnsemblBacteria BAA35237 http://www.ensemblgenomes.org/id/BAA35237 EnsemblBacteria b0607 http://www.ensemblgenomes.org/id/b0607 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004017 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004017 GO_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GO_process GO:0018117 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018117 GO_process GO:0046777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046777 GO_process GO:2000145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000145 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 GeneID 945229 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945229 HOGENOM HOG000238897 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000238897&db=HOGENOM6 InParanoid P39177 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39177 IntAct P39177 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39177* InterPro IPR006015 http://www.ebi.ac.uk/interpro/entry/IPR006015 InterPro IPR006016 http://www.ebi.ac.uk/interpro/entry/IPR006016 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 KEGG_Gene ecj:JW0600 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0600 KEGG_Gene eco:b0607 http://www.genome.jp/dbget-bin/www_bget?eco:b0607 KEGG_Orthology KO:K11932 http://www.genome.jp/dbget-bin/www_bget?KO:K11932 OMA VIRHTHI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VIRHTHI PRINTS PR01438 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01438 PSORT swissprot:USPG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:USPG_ECOLI PSORT-B swissprot:USPG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:USPG_ECOLI PSORT2 swissprot:USPG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:USPG_ECOLI Pfam PF00582 http://pfam.xfam.org/family/PF00582 Phobius swissprot:USPG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:USPG_ECOLI PhylomeDB P39177 http://phylomedb.org/?seqid=P39177 ProteinModelPortal P39177 http://www.proteinmodelportal.org/query/uniprot/P39177 PubMed 11849540 http://www.ncbi.nlm.nih.gov/pubmed/11849540 PubMed 12071968 http://www.ncbi.nlm.nih.gov/pubmed/12071968 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 RefSeq NP_415140 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415140 RefSeq WP_000278509 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000278509 SMR P39177 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39177 STRING 511145.b0607 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0607&targetmode=cogs STRING COG0589 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0589&targetmode=cogs SWISS-2DPAGE P39177 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P39177 UniProtKB USPG_ECOLI http://www.uniprot.org/uniprot/USPG_ECOLI UniProtKB-AC P39177 http://www.uniprot.org/uniprot/P39177 charge swissprot:USPG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:USPG_ECOLI eggNOG COG0589 http://eggnogapi.embl.de/nog_data/html/tree/COG0589 eggNOG ENOG4108U51 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108U51 epestfind swissprot:USPG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:USPG_ECOLI garnier swissprot:USPG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:USPG_ECOLI helixturnhelix swissprot:USPG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:USPG_ECOLI hmoment swissprot:USPG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:USPG_ECOLI iep swissprot:USPG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:USPG_ECOLI inforesidue swissprot:USPG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:USPG_ECOLI octanol swissprot:USPG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:USPG_ECOLI pepcoil swissprot:USPG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:USPG_ECOLI pepdigest swissprot:USPG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:USPG_ECOLI pepinfo swissprot:USPG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:USPG_ECOLI pepnet swissprot:USPG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:USPG_ECOLI pepstats swissprot:USPG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:USPG_ECOLI pepwheel swissprot:USPG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:USPG_ECOLI pepwindow swissprot:USPG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:USPG_ECOLI sigcleave swissprot:USPG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:USPG_ECOLI ## Database ID URL or Descriptions # BRENDA 3.7.1.14 2026 # BioGrid 4261575 12 # EcoGene EG13458 hcaC # FUNCTION HCAC_ECOLI Part of the multicomponent 3-phenylpropionate dioxygenase, that converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP- dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol), respectively. This protein seems to be a 2Fe-2S ferredoxin. # GO_function GO:0008695 3-phenylpropionate dioxygenase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051536 iron-sulfur cluster binding; IDA:EcoliWiki. # GO_function GO:0051537 2 iron, 2 sulfur cluster binding; IDA:EcoCyc. # GO_process GO:0019380 3-phenylpropionate catabolic process; IMP:EcoCyc. # GO_process GO:0019439 aromatic compound catabolic process; IEA:UniProtKB-HAMAP. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 2.102.10.10 -; 1. # HAMAP MF_01650 HcaC # IntAct P0ABW0 4 # InterPro IPR017941 Rieske_2Fe-2S # InterPro IPR023739 HcaC # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Pathway ko00360 Phenylalanine metabolism # KEGG_Pathway ko00361 Chlorocyclohexane and chlorobenzene degradation # KEGG_Pathway ko00362 Benzoate degradation # KEGG_Pathway ko00621 Dioxin degradation # KEGG_Pathway ko00622 Xylene degradation # KEGG_Pathway ko00623 Toluene degradation # KEGG_Pathway ko00625 Chloroalkane and chloroalkene degradation # KEGG_Pathway ko00627 Aminobenzoate degradation # KEGG_Pathway ko00642 Ethylbenzene degradation # Organism HCAC_ECOLI Escherichia coli (strain K12) # PATHWAY HCAC_ECOLI Aromatic compound metabolism; 3-phenylpropanoate degradation. # PATRIC 32120477 VBIEscCol129921_2641 # PIR C65031 C65031 # PROSITE PS51296 RIESKE # Pfam PF00355 Rieske # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HCAC_ECOLI 3-phenylpropionate/cinnamic acid dioxygenase ferredoxin subunit # RefSeq NP_417035 NC_000913.3 # RefSeq WP_001080102 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial ring-hydroxylating dioxygenase ferredoxin component family. {ECO 0000305}. # SIMILARITY Contains 1 Rieske domain. {ECO 0000305}. # SUBUNIT This dioxygenase system consists of four proteins the two subunits of the hydroxylase component (HcaE and HcaF), a ferredoxin (HcaC) and a ferredoxin reductase (HcaD). # SUPFAM SSF50022 SSF50022 # eggNOG COG2146 LUCA # eggNOG ENOG4105VQD Bacteria BLAST swissprot:HCAC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HCAC_ECOLI BioCyc ECOL316407:JW2524-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2524-MONOMER BioCyc EcoCyc:HCAC-MONOMER http://biocyc.org/getid?id=EcoCyc:HCAC-MONOMER BioCyc MetaCyc:HCAC-MONOMER http://biocyc.org/getid?id=MetaCyc:HCAC-MONOMER COG COG2146 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2146 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL Y11070 http://www.ebi.ac.uk/ena/data/view/Y11070 EchoBASE EB3231 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3231 EcoGene EG13458 http://www.ecogene.org/geneInfo.php?eg_id=EG13458 EnsemblBacteria AAC75593 http://www.ensemblgenomes.org/id/AAC75593 EnsemblBacteria AAC75593 http://www.ensemblgenomes.org/id/AAC75593 EnsemblBacteria BAA16443 http://www.ensemblgenomes.org/id/BAA16443 EnsemblBacteria BAA16443 http://www.ensemblgenomes.org/id/BAA16443 EnsemblBacteria BAA16443 http://www.ensemblgenomes.org/id/BAA16443 EnsemblBacteria b2540 http://www.ensemblgenomes.org/id/b2540 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008695 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008695 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051536 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051536 GO_function GO:0051537 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051537 GO_process GO:0019380 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019380 GO_process GO:0019439 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019439 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 2.102.10.10 http://www.cathdb.info/version/latest/superfamily/2.102.10.10 GeneID 947015 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947015 HAMAP MF_01650 http://hamap.expasy.org/unirule/MF_01650 HOGENOM HOG000128541 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000128541&db=HOGENOM6 InParanoid P0ABW0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABW0 IntAct P0ABW0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABW0* InterPro IPR017941 http://www.ebi.ac.uk/interpro/entry/IPR017941 InterPro IPR023739 http://www.ebi.ac.uk/interpro/entry/IPR023739 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Gene ecj:JW2524 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2524 KEGG_Gene eco:b2540 http://www.genome.jp/dbget-bin/www_bget?eco:b2540 KEGG_Orthology KO:K05710 http://www.genome.jp/dbget-bin/www_bget?KO:K05710 KEGG_Pathway ko00360 http://www.genome.jp/kegg-bin/show_pathway?ko00360 KEGG_Pathway ko00361 http://www.genome.jp/kegg-bin/show_pathway?ko00361 KEGG_Pathway ko00362 http://www.genome.jp/kegg-bin/show_pathway?ko00362 KEGG_Pathway ko00621 http://www.genome.jp/kegg-bin/show_pathway?ko00621 KEGG_Pathway ko00622 http://www.genome.jp/kegg-bin/show_pathway?ko00622 KEGG_Pathway ko00623 http://www.genome.jp/kegg-bin/show_pathway?ko00623 KEGG_Pathway ko00625 http://www.genome.jp/kegg-bin/show_pathway?ko00625 KEGG_Pathway ko00627 http://www.genome.jp/kegg-bin/show_pathway?ko00627 KEGG_Pathway ko00642 http://www.genome.jp/kegg-bin/show_pathway?ko00642 KEGG_Reaction rn:R00823 http://www.genome.jp/dbget-bin/www_bget?rn:R00823 KEGG_Reaction rn:R00825 http://www.genome.jp/dbget-bin/www_bget?rn:R00825 KEGG_Reaction rn:R03543 http://www.genome.jp/dbget-bin/www_bget?rn:R03543 KEGG_Reaction rn:R03559 http://www.genome.jp/dbget-bin/www_bget?rn:R03559 KEGG_Reaction rn:R05247 http://www.genome.jp/dbget-bin/www_bget?rn:R05247 KEGG_Reaction rn:R05261 http://www.genome.jp/dbget-bin/www_bget?rn:R05261 KEGG_Reaction rn:R05262 http://www.genome.jp/dbget-bin/www_bget?rn:R05262 KEGG_Reaction rn:R05263 http://www.genome.jp/dbget-bin/www_bget?rn:R05263 KEGG_Reaction rn:R05264 http://www.genome.jp/dbget-bin/www_bget?rn:R05264 KEGG_Reaction rn:R05440 http://www.genome.jp/dbget-bin/www_bget?rn:R05440 KEGG_Reaction rn:R06782 http://www.genome.jp/dbget-bin/www_bget?rn:R06782 KEGG_Reaction rn:R06783 http://www.genome.jp/dbget-bin/www_bget?rn:R06783 KEGG_Reaction rn:R09151 http://www.genome.jp/dbget-bin/www_bget?rn:R09151 KEGG_Reaction rn:R09152 http://www.genome.jp/dbget-bin/www_bget?rn:R09152 OMA CAIECWL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CAIECWL PROSITE PS51296 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51296 PSORT swissprot:HCAC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HCAC_ECOLI PSORT-B swissprot:HCAC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HCAC_ECOLI PSORT2 swissprot:HCAC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HCAC_ECOLI Pfam PF00355 http://pfam.xfam.org/family/PF00355 Phobius swissprot:HCAC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HCAC_ECOLI PhylomeDB P0ABW0 http://phylomedb.org/?seqid=P0ABW0 ProteinModelPortal P0ABW0 http://www.proteinmodelportal.org/query/uniprot/P0ABW0 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9603882 http://www.ncbi.nlm.nih.gov/pubmed/9603882 RefSeq NP_417035 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417035 RefSeq WP_001080102 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001080102 SMR P0ABW0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABW0 STRING 511145.b2540 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2540&targetmode=cogs STRING COG2146 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2146&targetmode=cogs SUPFAM SSF50022 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50022 UniProtKB HCAC_ECOLI http://www.uniprot.org/uniprot/HCAC_ECOLI UniProtKB-AC P0ABW0 http://www.uniprot.org/uniprot/P0ABW0 charge swissprot:HCAC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HCAC_ECOLI eggNOG COG2146 http://eggnogapi.embl.de/nog_data/html/tree/COG2146 eggNOG ENOG4105VQD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VQD epestfind swissprot:HCAC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HCAC_ECOLI garnier swissprot:HCAC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HCAC_ECOLI helixturnhelix swissprot:HCAC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HCAC_ECOLI hmoment swissprot:HCAC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HCAC_ECOLI iep swissprot:HCAC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HCAC_ECOLI inforesidue swissprot:HCAC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HCAC_ECOLI octanol swissprot:HCAC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HCAC_ECOLI pepcoil swissprot:HCAC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HCAC_ECOLI pepdigest swissprot:HCAC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HCAC_ECOLI pepinfo swissprot:HCAC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HCAC_ECOLI pepnet swissprot:HCAC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HCAC_ECOLI pepstats swissprot:HCAC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HCAC_ECOLI pepwheel swissprot:HCAC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HCAC_ECOLI pepwindow swissprot:HCAC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HCAC_ECOLI sigcleave swissprot:HCAC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HCAC_ECOLI ## Database ID URL or Descriptions # BioGrid 4260082 7 # CATALYTIC ACTIVITY DHNA_ECOLI NADH + acceptor = NAD(+) + reduced acceptor. # COFACTOR DHNA_ECOLI Name=FAD; Xref=ChEBI CHEBI 57692; Evidence={ECO 0000250}; Note=Binds 1 FAD per subunit. {ECO 0000250}; # EcoGene EG10649 ndh # FUNCTION DHNA_ECOLI Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Does not couple the redox reaction to proton translocation. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0030964 NADH dehydrogenase complex; IDA:EcoCyc. # GO_function GO:0008137 NADH dehydrogenase (ubiquinone) activity; IDA:EcoCyc. # GO_function GO:0050660 flavin adenine dinucleotide binding; IDA:EcoCyc. # GO_process GO:0009060 aerobic respiration; IMP:EcoCyc. # GO_process GO:0009061 anaerobic respiration; IMP:EcoCyc. # GO_process GO:0019646 aerobic electron transport chain; IDA:EcoCyc. # GO_process GO:0055070 copper ion homeostasis; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0042592 homeostatic process # Gene3D 3.50.50.60 -; 2. # INDUCTION DHNA_ECOLI Expressed aerobically and repressed in fermentation. # IntAct P00393 9 # InterPro IPR023753 FAD/NAD-binding_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00190 Oxidative phosphorylation # Organism DHNA_ECOLI Escherichia coli (strain K12) # PATRIC 32117461 VBIEscCol129921_1153 # PDB 1OZK Model; -; A=2-386 # PIR A00461 DEECR # PeroxiBase 5949 EcoNadDH_K12 # Pfam PF07992 Pyr_redox_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DHNA_ECOLI NADH dehydrogenase # RefSeq NP_415627 NC_000913.3 # RefSeq WP_000211045 NZ_LN832404.1 # SIMILARITY Belongs to the NADH dehydrogenase family. {ECO 0000305}. # SUBCELLULAR LOCATION DHNA_ECOLI Cell membrane. # SUPFAM SSF51905 SSF51905 # eggNOG COG1252 LUCA # eggNOG ENOG4105CEP Bacteria BLAST swissprot:DHNA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DHNA_ECOLI BioCyc ECOL316407:JW1095-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1095-MONOMER BioCyc EcoCyc:NADH-DHII-MONOMER http://biocyc.org/getid?id=EcoCyc:NADH-DHII-MONOMER BioCyc MetaCyc:NADH-DHII-MONOMER http://biocyc.org/getid?id=MetaCyc:NADH-DHII-MONOMER COG COG1252 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1252 DIP DIP-10325N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10325N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1432-1033.1981.tb05314.x http://dx.doi.org/10.1111/j.1432-1033.1981.tb05314.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.6.99.3 http://www.genome.jp/dbget-bin/www_bget?EC:1.6.99.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00306 http://www.ebi.ac.uk/ena/data/view/V00306 ENZYME 1.6.99.3 http://enzyme.expasy.org/EC/1.6.99.3 EchoBASE EB0643 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0643 EcoGene EG10649 http://www.ecogene.org/geneInfo.php?eg_id=EG10649 EnsemblBacteria AAC74193 http://www.ensemblgenomes.org/id/AAC74193 EnsemblBacteria AAC74193 http://www.ensemblgenomes.org/id/AAC74193 EnsemblBacteria BAA35924 http://www.ensemblgenomes.org/id/BAA35924 EnsemblBacteria BAA35924 http://www.ensemblgenomes.org/id/BAA35924 EnsemblBacteria BAA35924 http://www.ensemblgenomes.org/id/BAA35924 EnsemblBacteria b1109 http://www.ensemblgenomes.org/id/b1109 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0030964 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030964 GO_function GO:0008137 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008137 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_process GO:0009060 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009060 GO_process GO:0009061 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009061 GO_process GO:0019646 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019646 GO_process GO:0055070 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055070 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 GeneID 946792 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946792 HOGENOM HOG000157010 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000157010&db=HOGENOM6 InParanoid P00393 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00393 IntAct P00393 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00393* IntEnz 1.6.99.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.6.99.3 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1095 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1095 KEGG_Gene eco:b1109 http://www.genome.jp/dbget-bin/www_bget?eco:b1109 KEGG_Orthology KO:K03885 http://www.genome.jp/dbget-bin/www_bget?KO:K03885 KEGG_Pathway ko00190 http://www.genome.jp/kegg-bin/show_pathway?ko00190 OMA HQMASLV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HQMASLV PDB 1OZK http://www.ebi.ac.uk/pdbe-srv/view/entry/1OZK PDBsum 1OZK http://www.ebi.ac.uk/pdbsum/1OZK PSORT swissprot:DHNA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DHNA_ECOLI PSORT-B swissprot:DHNA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DHNA_ECOLI PSORT2 swissprot:DHNA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DHNA_ECOLI PeroxiBase 5949 http://peroxibase.toulouse.inra.fr/listing.php?action=view&id=5949 Pfam PF07992 http://pfam.xfam.org/family/PF07992 Phobius swissprot:DHNA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DHNA_ECOLI PhylomeDB P00393 http://phylomedb.org/?seqid=P00393 ProteinModelPortal P00393 http://www.proteinmodelportal.org/query/uniprot/P00393 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6265208 http://www.ncbi.nlm.nih.gov/pubmed/6265208 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415627 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415627 RefSeq WP_000211045 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000211045 SMR P00393 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00393 STRING 511145.b1109 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1109&targetmode=cogs STRING COG1252 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1252&targetmode=cogs SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 UniProtKB DHNA_ECOLI http://www.uniprot.org/uniprot/DHNA_ECOLI UniProtKB-AC P00393 http://www.uniprot.org/uniprot/P00393 charge swissprot:DHNA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DHNA_ECOLI eggNOG COG1252 http://eggnogapi.embl.de/nog_data/html/tree/COG1252 eggNOG ENOG4105CEP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CEP epestfind swissprot:DHNA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DHNA_ECOLI garnier swissprot:DHNA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DHNA_ECOLI helixturnhelix swissprot:DHNA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DHNA_ECOLI hmoment swissprot:DHNA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DHNA_ECOLI iep swissprot:DHNA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DHNA_ECOLI inforesidue swissprot:DHNA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DHNA_ECOLI octanol swissprot:DHNA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DHNA_ECOLI pepcoil swissprot:DHNA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DHNA_ECOLI pepdigest swissprot:DHNA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DHNA_ECOLI pepinfo swissprot:DHNA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DHNA_ECOLI pepnet swissprot:DHNA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DHNA_ECOLI pepstats swissprot:DHNA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DHNA_ECOLI pepwheel swissprot:DHNA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DHNA_ECOLI pepwindow swissprot:DHNA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DHNA_ECOLI sigcleave swissprot:DHNA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DHNA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261827 171 # EcoGene EG11007 tolA # FUNCTION TOLA_ECOLI Involved in the TonB-independent uptake of group A colicins (colicins A, E1, E2, E3, and K). Necessary for the colicins to reach their respective targets after initial binding to the bacteria. Also involved in the translocation of bacteriophage DNA. # GO_component GO:0005886 plasma membrane; IDA:EcoliWiki. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IDA:EcoliWiki. # GO_component GO:0032153 cell division site; IDA:EcoCyc. # GO_function GO:0005215 transporter activity; IEA:InterPro. # GO_process GO:0017038 protein import; IMP:EcoliWiki. # GO_process GO:0043213 bacteriocin transport; IMP:EcoliWiki. # GO_process GO:0046718 viral entry into host cell; IDA:EcoCyc. # GO_process GO:0051301 cell division; IDA:EcoCyc. # GO_process GO:0071237 cellular response to bacteriocin; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # GOslim_process GO:0051301 cell division # INTERACTION TOLA_ECOLI P04480 caa (xeno); NbExp=6; IntAct=EBI-1120026, EBI-6559916; P0A855 tolB; NbExp=5; IntAct=EBI-1120026, EBI-7180728; # IntAct P19934 8 # InterPro IPR014161 Tol-Pal_TolA # KEGG_Brite ko02000 Transporters # Organism TOLA_ECOLI Escherichia coli (strain K12) # PATRIC 32116677 VBIEscCol129921_0771 # PDB 1S62 NMR; -; A=325-421 # PDB 1TOL X-ray; 1.85 A; A=295-421 # PDB 3QDP X-ray; 2.15 A; A=302-421 # PDB 3QDR X-ray; 2.65 A; A=302-421 # PIR JV0057 JV0057 # Pfam PF06519 TolA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TOLA_ECOLI Protein TolA # RefSeq NP_415267 NC_000913.3 # RefSeq WP_000030637 NZ_LN832404.1 # SUBCELLULAR LOCATION TOLA_ECOLI Cell inner membrane; Single-pass type II membrane protein. # SUBUNIT Interacts, via domain II, with porins OmpC, PhoE and LamB. {ECO:0000269|PubMed 8978668}. # TCDB 2.C.1.2 the tonb-exbb-exbd/tola-tolq-tolr (tonb) family of auxiliary proteins for energization of outer membrane receptor (omr)-mediated active transport # TIGRFAMs TIGR02794 tolA_full; 2 # eggNOG COG3064 LUCA # eggNOG ENOG4108Z82 Bacteria BLAST swissprot:TOLA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TOLA_ECOLI BioCyc ECOL316407:JW0729-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0729-MONOMER BioCyc EcoCyc:EG11007-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11007-MONOMER COG COG3064 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3064 DIP DIP-11005N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11005N DOI 10.1016/S0969-2126(99)80092-6 http://dx.doi.org/10.1016/S0969-2126(99)80092-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.88.14.5939 http://dx.doi.org/10.1073/pnas.88.14.5939 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M28232 http://www.ebi.ac.uk/ena/data/view/M28232 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1000 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1000 EcoGene EG11007 http://www.ecogene.org/geneInfo.php?eg_id=EG11007 EnsemblBacteria AAC73833 http://www.ensemblgenomes.org/id/AAC73833 EnsemblBacteria AAC73833 http://www.ensemblgenomes.org/id/AAC73833 EnsemblBacteria BAA35405 http://www.ensemblgenomes.org/id/BAA35405 EnsemblBacteria BAA35405 http://www.ensemblgenomes.org/id/BAA35405 EnsemblBacteria BAA35405 http://www.ensemblgenomes.org/id/BAA35405 EnsemblBacteria b0739 http://www.ensemblgenomes.org/id/b0739 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0032153 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032153 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_process GO:0017038 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017038 GO_process GO:0043213 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043213 GO_process GO:0046718 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046718 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GO_process GO:0071237 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071237 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GeneID 946625 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946625 HOGENOM HOG000283070 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000283070&db=HOGENOM6 IntAct P19934 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P19934* InterPro IPR014161 http://www.ebi.ac.uk/interpro/entry/IPR014161 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0729 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0729 KEGG_Gene eco:b0739 http://www.genome.jp/dbget-bin/www_bget?eco:b0739 KEGG_Orthology KO:K03646 http://www.genome.jp/dbget-bin/www_bget?KO:K03646 MINT MINT-7888479 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-7888479 PDB 1S62 http://www.ebi.ac.uk/pdbe-srv/view/entry/1S62 PDB 1TOL http://www.ebi.ac.uk/pdbe-srv/view/entry/1TOL PDB 3QDP http://www.ebi.ac.uk/pdbe-srv/view/entry/3QDP PDB 3QDR http://www.ebi.ac.uk/pdbe-srv/view/entry/3QDR PDBsum 1S62 http://www.ebi.ac.uk/pdbsum/1S62 PDBsum 1TOL http://www.ebi.ac.uk/pdbsum/1TOL PDBsum 3QDP http://www.ebi.ac.uk/pdbsum/3QDP PDBsum 3QDR http://www.ebi.ac.uk/pdbsum/3QDR PSORT swissprot:TOLA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TOLA_ECOLI PSORT-B swissprot:TOLA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TOLA_ECOLI PSORT2 swissprot:TOLA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TOLA_ECOLI Pfam PF06519 http://pfam.xfam.org/family/PF06519 Phobius swissprot:TOLA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TOLA_ECOLI ProteinModelPortal P19934 http://www.proteinmodelportal.org/query/uniprot/P19934 PubMed 10404600 http://www.ncbi.nlm.nih.gov/pubmed/10404600 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2068069 http://www.ncbi.nlm.nih.gov/pubmed/2068069 PubMed 2687247 http://www.ncbi.nlm.nih.gov/pubmed/2687247 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 8978668 http://www.ncbi.nlm.nih.gov/pubmed/8978668 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415267 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415267 RefSeq WP_000030637 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000030637 SMR P19934 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P19934 STRING 511145.b0739 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0739&targetmode=cogs STRING COG3064 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3064&targetmode=cogs TCDB 2.C.1.2 http://www.tcdb.org/search/result.php?tc=2.C.1.2 TIGRFAMs TIGR02794 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02794 UniProtKB TOLA_ECOLI http://www.uniprot.org/uniprot/TOLA_ECOLI UniProtKB-AC P19934 http://www.uniprot.org/uniprot/P19934 charge swissprot:TOLA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TOLA_ECOLI eggNOG COG3064 http://eggnogapi.embl.de/nog_data/html/tree/COG3064 eggNOG ENOG4108Z82 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Z82 epestfind swissprot:TOLA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TOLA_ECOLI garnier swissprot:TOLA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TOLA_ECOLI helixturnhelix swissprot:TOLA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TOLA_ECOLI hmoment swissprot:TOLA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TOLA_ECOLI iep swissprot:TOLA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TOLA_ECOLI inforesidue swissprot:TOLA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TOLA_ECOLI octanol swissprot:TOLA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TOLA_ECOLI pepcoil swissprot:TOLA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TOLA_ECOLI pepdigest swissprot:TOLA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TOLA_ECOLI pepinfo swissprot:TOLA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TOLA_ECOLI pepnet swissprot:TOLA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TOLA_ECOLI pepstats swissprot:TOLA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TOLA_ECOLI pepwheel swissprot:TOLA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TOLA_ECOLI pepwindow swissprot:TOLA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TOLA_ECOLI sigcleave swissprot:TOLA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TOLA_ECOLI ## Database ID URL or Descriptions # AltName MOAD_ECOLI MPT synthase subunit 1 # AltName MOAD_ECOLI Molybdenum cofactor biosynthesis protein D # AltName MOAD_ECOLI Molybdopterin-converting factor small subunit # AltName MOAD_ECOLI Molybdopterin-converting factor subunit 1 # AltName MOAD_ECOLI Sulfur carrier protein MoaD # BioGrid 4262177 13 # EcoGene EG11597 moaD # FUNCTION MOAD_ECOLI Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin. {ECO 0000269|PubMed 17223713}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000166 nucleotide binding; IEA:UniProtKB-KW. # GO_process GO:0006777 Mo-molybdopterin cofactor biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.10.20.30 -; 1. # INDUCTION MOAD_ECOLI By anaerobiosis, repressed by the molybdenum cofactor. # INTERACTION MOAD_ECOLI P30749 moaE; NbExp=7; IntAct=EBI-554366, EBI-554376; # IntAct P30748 16 # InterPro IPR003749 ThiS/MoaD # InterPro IPR010034 Mopterin_su_1 # InterPro IPR012675 Beta-grasp_dom # InterPro IPR016155 Mopterin_synth/thiamin_S_b # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko00790 Folate biosynthesis # KEGG_Pathway ko04122 Sulfur relay system # MASS SPECTROMETRY Mass=8744; Method=API; Range=1-81; Evidence={ECO:0000269|PubMed 11135669}; # MASS SPECTROMETRY Mass=8744; Method=Electrospray; Range=1-81; Evidence={ECO:0000269|PubMed 11463785}; # MASS SPECTROMETRY Mass=8757.0; Mass_error=1.0; Method=Electrospray; Range=1-81; Evidence={ECO:0000269|PubMed 8514782}; # MASS SPECTROMETRY Mass=8760; Method=API; Range=1-81; Note=The measured mass is that of the thiolated protein.; Evidence={ECO:0000269|PubMed 11135669}; # MASS SPECTROMETRY Mass=8773.6; Mass_error=0.2; Method=Electrospray; Range=1-81; Note=The measured mass is that of the thiolated protein.; Evidence={ECO:0000269|PubMed 8514782}; # MISCELLANEOUS MOAD_ECOLI The cross-link is not seen in all structures of the MoaE-MoaD complex. # Organism MOAD_ECOLI Escherichia coli (strain K12) # PATHWAY MOAD_ECOLI Cofactor biosynthesis; molybdopterin biosynthesis. # PATRIC 32116769 VBIEscCol129921_0810 # PDB 1FM0 X-ray; 1.45 A; D=1-81 # PDB 1FMA X-ray; 1.58 A; D=1-81 # PDB 1JW9 X-ray; 1.70 A; D=1-81 # PDB 1JWA X-ray; 2.90 A; D=1-81 # PDB 1JWB X-ray; 2.10 A; D=1-81 # PDB 1NVI X-ray; 1.90 A; D=1-81 # PDB 3BII X-ray; 2.50 A; D=1-81 # PIR H64814 H64814 # PTM MOAD_ECOLI C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) by MoeB, then thiocarboxylated (-COSH) by IscS. {ECO 0000269|PubMed 12571227}. # Pfam PF02597 ThiS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MOAD_ECOLI Molybdopterin synthase sulfur carrier subunit # RefSeq NP_415305 NC_000913.3 # RefSeq WP_000598619 NZ_LN832404.1 # SIMILARITY Belongs to the MoaD family. {ECO 0000305}. # SUBUNIT MOAD_ECOLI Heterotetramer of 2 MoaD subunits and 2 MoaE subunits. Forms a stable heterotetrameric complex of 2 MoaD and 2 MoeB during adenylation of MoaD by MoeB. During catalysis MoaD shuttles between the two heterotetrameric complexes. {ECO 0000269|PubMed 11135669, ECO 0000269|PubMed 12571227}. # SUPFAM SSF54285 SSF54285 # TIGRFAMs TIGR01682 moaD # eggNOG COG1977 LUCA # eggNOG ENOG4105M00 Bacteria BLAST swissprot:MOAD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MOAD_ECOLI BioCyc ECOL316407:JW0767-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0767-MONOMER BioCyc EcoCyc:EG11597-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11597-MONOMER BioCyc MetaCyc:EG11597-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11597-MONOMER COG COG1977 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1977 DIP DIP-10231N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10231N DOI 10.1021/bi062011w http://dx.doi.org/10.1021/bi062011w DOI 10.1038/35104586 http://dx.doi.org/10.1038/35104586 DOI 10.1038/83034 http://dx.doi.org/10.1038/83034 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M102787200 http://dx.doi.org/10.1074/jbc.M102787200 DOI 10.1074/jbc.M109.082172 http://dx.doi.org/10.1074/jbc.M109.082172 DOI 10.1074/jbc.M300449200 http://dx.doi.org/10.1074/jbc.M300449200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1993.tb01652.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb01652.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X70420 http://www.ebi.ac.uk/ena/data/view/X70420 EchoBASE EB1554 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1554 EcoGene EG11597 http://www.ecogene.org/geneInfo.php?eg_id=EG11597 EnsemblBacteria AAC73871 http://www.ensemblgenomes.org/id/AAC73871 EnsemblBacteria AAC73871 http://www.ensemblgenomes.org/id/AAC73871 EnsemblBacteria BAA35442 http://www.ensemblgenomes.org/id/BAA35442 EnsemblBacteria BAA35442 http://www.ensemblgenomes.org/id/BAA35442 EnsemblBacteria BAA35442 http://www.ensemblgenomes.org/id/BAA35442 EnsemblBacteria b0784 http://www.ensemblgenomes.org/id/b0784 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000166 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000166 GO_process GO:0006777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006777 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.10.20.30 http://www.cathdb.info/version/latest/superfamily/3.10.20.30 GeneID 945398 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945398 HOGENOM HOG000280988 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000280988&db=HOGENOM6 InParanoid P30748 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30748 IntAct P30748 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P30748* InterPro IPR003749 http://www.ebi.ac.uk/interpro/entry/IPR003749 InterPro IPR010034 http://www.ebi.ac.uk/interpro/entry/IPR010034 InterPro IPR012675 http://www.ebi.ac.uk/interpro/entry/IPR012675 InterPro IPR016155 http://www.ebi.ac.uk/interpro/entry/IPR016155 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW0767 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0767 KEGG_Gene eco:b0784 http://www.genome.jp/dbget-bin/www_bget?eco:b0784 KEGG_Orthology KO:K03636 http://www.genome.jp/dbget-bin/www_bget?KO:K03636 KEGG_Pathway ko00790 http://www.genome.jp/kegg-bin/show_pathway?ko00790 KEGG_Pathway ko04122 http://www.genome.jp/kegg-bin/show_pathway?ko04122 KEGG_Reaction rn:R09395 http://www.genome.jp/dbget-bin/www_bget?rn:R09395 MINT MINT-155528 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-155528 OMA RELVACD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RELVACD PDB 1FM0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1FM0 PDB 1FMA http://www.ebi.ac.uk/pdbe-srv/view/entry/1FMA PDB 1JW9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1JW9 PDB 1JWA http://www.ebi.ac.uk/pdbe-srv/view/entry/1JWA PDB 1JWB http://www.ebi.ac.uk/pdbe-srv/view/entry/1JWB PDB 1NVI http://www.ebi.ac.uk/pdbe-srv/view/entry/1NVI PDB 3BII http://www.ebi.ac.uk/pdbe-srv/view/entry/3BII PDBsum 1FM0 http://www.ebi.ac.uk/pdbsum/1FM0 PDBsum 1FMA http://www.ebi.ac.uk/pdbsum/1FMA PDBsum 1JW9 http://www.ebi.ac.uk/pdbsum/1JW9 PDBsum 1JWA http://www.ebi.ac.uk/pdbsum/1JWA PDBsum 1JWB http://www.ebi.ac.uk/pdbsum/1JWB PDBsum 1NVI http://www.ebi.ac.uk/pdbsum/1NVI PDBsum 3BII http://www.ebi.ac.uk/pdbsum/3BII PSORT swissprot:MOAD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MOAD_ECOLI PSORT-B swissprot:MOAD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MOAD_ECOLI PSORT2 swissprot:MOAD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MOAD_ECOLI Pfam PF02597 http://pfam.xfam.org/family/PF02597 Phobius swissprot:MOAD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MOAD_ECOLI PhylomeDB P30748 http://phylomedb.org/?seqid=P30748 ProteinModelPortal P30748 http://www.proteinmodelportal.org/query/uniprot/P30748 PubMed 11135669 http://www.ncbi.nlm.nih.gov/pubmed/11135669 PubMed 11463785 http://www.ncbi.nlm.nih.gov/pubmed/11463785 PubMed 11713534 http://www.ncbi.nlm.nih.gov/pubmed/11713534 PubMed 12571227 http://www.ncbi.nlm.nih.gov/pubmed/12571227 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17223713 http://www.ncbi.nlm.nih.gov/pubmed/17223713 PubMed 19946146 http://www.ncbi.nlm.nih.gov/pubmed/19946146 PubMed 8361352 http://www.ncbi.nlm.nih.gov/pubmed/8361352 PubMed 8514782 http://www.ncbi.nlm.nih.gov/pubmed/8514782 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415305 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415305 RefSeq WP_000598619 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000598619 SMR P30748 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P30748 STRING 511145.b0784 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0784&targetmode=cogs STRING COG1977 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1977&targetmode=cogs SUPFAM SSF54285 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54285 TIGRFAMs TIGR01682 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01682 UniProtKB MOAD_ECOLI http://www.uniprot.org/uniprot/MOAD_ECOLI UniProtKB-AC P30748 http://www.uniprot.org/uniprot/P30748 charge swissprot:MOAD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MOAD_ECOLI eggNOG COG1977 http://eggnogapi.embl.de/nog_data/html/tree/COG1977 eggNOG ENOG4105M00 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105M00 epestfind swissprot:MOAD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MOAD_ECOLI garnier swissprot:MOAD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MOAD_ECOLI helixturnhelix swissprot:MOAD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MOAD_ECOLI hmoment swissprot:MOAD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MOAD_ECOLI iep swissprot:MOAD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MOAD_ECOLI inforesidue swissprot:MOAD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MOAD_ECOLI octanol swissprot:MOAD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MOAD_ECOLI pepcoil swissprot:MOAD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MOAD_ECOLI pepdigest swissprot:MOAD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MOAD_ECOLI pepinfo swissprot:MOAD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MOAD_ECOLI pepnet swissprot:MOAD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MOAD_ECOLI pepstats swissprot:MOAD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MOAD_ECOLI pepwheel swissprot:MOAD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MOAD_ECOLI pepwindow swissprot:MOAD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MOAD_ECOLI sigcleave swissprot:MOAD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MOAD_ECOLI ## Database ID URL or Descriptions # EcoGene EG14499 pmrR # FUNCTION PMRR_ECOLI May bind to BasS and modulate its sensor kinase activity. {ECO 0000305}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # Organism PMRR_ECOLI Escherichia coli (strain K12) # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PMRR_ECOLI Putative membrane protein PmrR # RefSeq WP_000797657 NZ_LN832404.1 # RefSeq YP_004831120 NC_000913.3 # SUBCELLULAR LOCATION PMRR_ECOLI Cell inner membrane {ECO 0000305}; Single- pass membrane protein {ECO 0000305}. BLAST swissprot:PMRR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PMRR_ECOLI BioCyc EcoCyc:MONOMER0-4214 http://biocyc.org/getid?id=EcoCyc:MONOMER0-4214 DOI 10.1006/jmbi.1993.1030 http://dx.doi.org/10.1006/jmbi.1993.1030 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M83089 http://www.ebi.ac.uk/ena/data/view/M83089 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EcoGene EG14499 http://www.ecogene.org/geneInfo.php?eg_id=EG14499 EnsemblBacteria AEN84234 http://www.ensemblgenomes.org/id/AEN84234 EnsemblBacteria AEN84234 http://www.ensemblgenomes.org/id/AEN84234 EnsemblBacteria b4703 http://www.ensemblgenomes.org/id/b4703 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 11115379 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11115379 KEGG_Gene eco:b4703 http://www.genome.jp/dbget-bin/www_bget?eco:b4703 PSORT swissprot:PMRR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PMRR_ECOLI PSORT-B swissprot:PMRR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PMRR_ECOLI PSORT2 swissprot:PMRR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PMRR_ECOLI Phobius swissprot:PMRR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PMRR_ECOLI PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8421314 http://www.ncbi.nlm.nih.gov/pubmed/8421314 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000797657 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000797657 RefSeq YP_004831120 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_004831120 STRING 511145.b4703 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4703&targetmode=cogs UniProtKB PMRR_ECOLI http://www.uniprot.org/uniprot/PMRR_ECOLI UniProtKB-AC G3MTW7 http://www.uniprot.org/uniprot/G3MTW7 charge swissprot:PMRR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PMRR_ECOLI epestfind swissprot:PMRR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PMRR_ECOLI garnier swissprot:PMRR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PMRR_ECOLI helixturnhelix swissprot:PMRR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PMRR_ECOLI hmoment swissprot:PMRR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PMRR_ECOLI iep swissprot:PMRR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PMRR_ECOLI inforesidue swissprot:PMRR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PMRR_ECOLI octanol swissprot:PMRR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PMRR_ECOLI pepcoil swissprot:PMRR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PMRR_ECOLI pepdigest swissprot:PMRR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PMRR_ECOLI pepinfo swissprot:PMRR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PMRR_ECOLI pepnet swissprot:PMRR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PMRR_ECOLI pepstats swissprot:PMRR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PMRR_ECOLI pepwheel swissprot:PMRR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PMRR_ECOLI pepwindow swissprot:PMRR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PMRR_ECOLI sigcleave swissprot:PMRR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PMRR_ECOLI ## Database ID URL or Descriptions # BioGrid 4259981 702 # ENZYME REGULATION Inhibited by verapamil but not by carbonyl cyanide m-chlorophenylhydrazone (CCCP). {ECO:0000269|PubMed 16109926}. # EcoGene EG13472 gsiA # FUNCTION GSIA_ECOLI Part of the ABC transporter complex GsiABCD involved in glutathione import. Responsible for energy coupling to the transport system. {ECO 0000269|PubMed 16109926}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0043492 ATPase activity, coupled to movement of substances; IMP:EcoCyc. # GO_process GO:0034775 glutathione transmembrane transport; IMP:EcoCyc. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0055085 transmembrane transport # Gene3D 3.40.50.300 -; 2. # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR013563 Oligopep_ABC_C # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00348 Glutathione transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism GSIA_ECOLI Escherichia coli (strain K12) # PATRIC 32116861 VBIEscCol129921_0856 # PIR E64820 E64820 # PROSITE PS00211 ABC_TRANSPORTER_1; 2 # PROSITE PS50893 ABC_TRANSPORTER_2; 2 # Pfam PF00005 ABC_tran; 2 # Pfam PF08352 oligo_HPY; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GSIA_ECOLI Glutathione import ATP-binding protein GsiA # RefSeq NP_415350 NC_000913.3 # RefSeq WP_001301279 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA35517.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ABC transporter superfamily. Glutathione importer (TC 3.A.1.5.11) family. {ECO 0000305}. # SIMILARITY Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA; 2 # SUBCELLULAR LOCATION GSIA_ECOLI Cell inner membrane {ECO 0000250}; Peripheral membrane protein {ECO 0000250}. # SUBUNIT The complex is composed of two ATP-binding proteins (GsiA), two transmembrane proteins (GsiC and GsiD) and a solute- binding protein (GsiB). {ECO 0000305}. # SUPFAM SSF52540 SSF52540; 2 # TCDB 3.A.1.5.11 the atp-binding cassette (abc) superfamily # eggNOG COG1123 LUCA # eggNOG ENOG4108JQ6 Bacteria BLAST swissprot:GSIA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GSIA_ECOLI BioCyc ECOL316407:JW5897-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5897-MONOMER BioCyc EcoCyc:YLIA-MONOMER http://biocyc.org/getid?id=EcoCyc:YLIA-MONOMER BioCyc MetaCyc:YLIA-MONOMER http://biocyc.org/getid?id=MetaCyc:YLIA-MONOMER COG COG1123 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1123 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.187.17.5861-5867.2005 http://dx.doi.org/10.1128/JB.187.17.5861-5867.2005 EC_number EC:3.6.3.- http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.6.3.- http://enzyme.expasy.org/EC/3.6.3.- EchoBASE EB3245 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3245 EcoGene EG13472 http://www.ecogene.org/geneInfo.php?eg_id=EG13472 EnsemblBacteria AAC73916 http://www.ensemblgenomes.org/id/AAC73916 EnsemblBacteria AAC73916 http://www.ensemblgenomes.org/id/AAC73916 EnsemblBacteria BAA35517 http://www.ensemblgenomes.org/id/BAA35517 EnsemblBacteria BAA35517 http://www.ensemblgenomes.org/id/BAA35517 EnsemblBacteria BAA35517 http://www.ensemblgenomes.org/id/BAA35517 EnsemblBacteria b0829 http://www.ensemblgenomes.org/id/b0829 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0043492 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043492 GO_process GO:0034775 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034775 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945457 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945457 InParanoid P75796 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75796 IntEnz 3.6.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3 InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR013563 http://www.ebi.ac.uk/interpro/entry/IPR013563 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5897 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5897 KEGG_Gene eco:b0829 http://www.genome.jp/dbget-bin/www_bget?eco:b0829 KEGG_Orthology KO:K13892 http://www.genome.jp/dbget-bin/www_bget?KO:K13892 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA ESIRVHQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ESIRVHQ PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:GSIA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GSIA_ECOLI PSORT-B swissprot:GSIA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GSIA_ECOLI PSORT2 swissprot:GSIA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GSIA_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Pfam PF08352 http://pfam.xfam.org/family/PF08352 Phobius swissprot:GSIA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GSIA_ECOLI PhylomeDB P75796 http://phylomedb.org/?seqid=P75796 ProteinModelPortal P75796 http://www.proteinmodelportal.org/query/uniprot/P75796 PubMed 16109926 http://www.ncbi.nlm.nih.gov/pubmed/16109926 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415350 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415350 RefSeq WP_001301279 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001301279 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 STRING 511145.b0829 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0829&targetmode=cogs STRING COG1123 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1123&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.5.11 http://www.tcdb.org/search/result.php?tc=3.A.1.5.11 UniProtKB GSIA_ECOLI http://www.uniprot.org/uniprot/GSIA_ECOLI UniProtKB-AC P75796 http://www.uniprot.org/uniprot/P75796 charge swissprot:GSIA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GSIA_ECOLI eggNOG COG1123 http://eggnogapi.embl.de/nog_data/html/tree/COG1123 eggNOG ENOG4108JQ6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108JQ6 epestfind swissprot:GSIA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GSIA_ECOLI garnier swissprot:GSIA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GSIA_ECOLI helixturnhelix swissprot:GSIA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GSIA_ECOLI hmoment swissprot:GSIA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GSIA_ECOLI iep swissprot:GSIA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GSIA_ECOLI inforesidue swissprot:GSIA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GSIA_ECOLI octanol swissprot:GSIA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GSIA_ECOLI pepcoil swissprot:GSIA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GSIA_ECOLI pepdigest swissprot:GSIA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GSIA_ECOLI pepinfo swissprot:GSIA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GSIA_ECOLI pepnet swissprot:GSIA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GSIA_ECOLI pepstats swissprot:GSIA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GSIA_ECOLI pepwheel swissprot:GSIA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GSIA_ECOLI pepwindow swissprot:GSIA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GSIA_ECOLI sigcleave swissprot:GSIA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GSIA_ECOLI ## Database ID URL or Descriptions # AltName EXOX_ECOLI Exodeoxyribonuclease X # BioGrid 4260363 106 # COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI 18420; # EcoGene EG14031 exoX # FUNCTION EXOX_ECOLI Capable of degrading both single-strand and double- strand DNA with 3' to 5' polarity. Has higher affinity for ssDNA ends than for dsDNA. # GO_function GO:0003676 nucleic acid binding; IEA:InterPro. # GO_function GO:0008408 3'-5' exonuclease activity; IDA:EcoCyc. # GO_process GO:0006298 mismatch repair; IDA:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0004518 nuclease activity # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # Gene3D 3.30.420.10 -; 1. # InterPro IPR012337 RNaseH-like_dom # InterPro IPR013520 Exonuclease_RNaseT/DNA_pol3 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko03430 Mismatch repair # Organism EXOX_ECOLI Escherichia coli (strain K12) # PATRIC 32119009 VBIEscCol129921_1922 # PDB 4FZX X-ray; 2.30 A; C/D=1-167 # PDB 4FZY X-ray; 2.50 A; A/B=1-167 # PDB 4FZZ X-ray; 2.80 A; A/B=1-167 # PIR D64946 D64946 # Pfam PF00929 RNase_T # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EXOX_ECOLI Exodeoxyribonuclease 10 # RefSeq NP_416358 NC_000913.3 # RefSeq WP_000944256 NZ_LN832404.1 # SMART SM00479 EXOIII # SUPFAM SSF53098 SSF53098 # eggNOG COG0847 LUCA # eggNOG ENOG4105UMD Bacteria BLAST swissprot:EXOX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EXOX_ECOLI BioCyc ECOL316407:JW1833-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1833-MONOMER BioCyc EcoCyc:G7016-MONOMER http://biocyc.org/getid?id=EcoCyc:G7016-MONOMER COG COG0847 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0847 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.274.42.30094 http://dx.doi.org/10.1074/jbc.274.42.30094 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.11.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.11.- EMBL AF194116 http://www.ebi.ac.uk/ena/data/view/AF194116 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.11.- http://enzyme.expasy.org/EC/3.1.11.- EchoBASE EB3785 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3785 EcoGene EG14031 http://www.ecogene.org/geneInfo.php?eg_id=EG14031 EnsemblBacteria AAC74914 http://www.ensemblgenomes.org/id/AAC74914 EnsemblBacteria AAC74914 http://www.ensemblgenomes.org/id/AAC74914 EnsemblBacteria BAE76547 http://www.ensemblgenomes.org/id/BAE76547 EnsemblBacteria BAE76547 http://www.ensemblgenomes.org/id/BAE76547 EnsemblBacteria BAE76547 http://www.ensemblgenomes.org/id/BAE76547 EnsemblBacteria b1844 http://www.ensemblgenomes.org/id/b1844 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003676 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003676 GO_function GO:0008408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008408 GO_process GO:0006298 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006298 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.30.420.10 http://www.cathdb.info/version/latest/superfamily/3.30.420.10 GeneID 946361 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946361 HOGENOM HOG000121240 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000121240&db=HOGENOM6 InParanoid P0AEK0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEK0 IntEnz 3.1.11 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.11 InterPro IPR012337 http://www.ebi.ac.uk/interpro/entry/IPR012337 InterPro IPR013520 http://www.ebi.ac.uk/interpro/entry/IPR013520 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW1833 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1833 KEGG_Gene eco:b1844 http://www.genome.jp/dbget-bin/www_bget?eco:b1844 KEGG_Orthology KO:K10857 http://www.genome.jp/dbget-bin/www_bget?KO:K10857 KEGG_Pathway ko03430 http://www.genome.jp/kegg-bin/show_pathway?ko03430 OMA MAIHKIT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MAIHKIT PDB 4FZX http://www.ebi.ac.uk/pdbe-srv/view/entry/4FZX PDB 4FZY http://www.ebi.ac.uk/pdbe-srv/view/entry/4FZY PDB 4FZZ http://www.ebi.ac.uk/pdbe-srv/view/entry/4FZZ PDBsum 4FZX http://www.ebi.ac.uk/pdbsum/4FZX PDBsum 4FZY http://www.ebi.ac.uk/pdbsum/4FZY PDBsum 4FZZ http://www.ebi.ac.uk/pdbsum/4FZZ PSORT swissprot:EXOX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EXOX_ECOLI PSORT-B swissprot:EXOX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EXOX_ECOLI PSORT2 swissprot:EXOX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EXOX_ECOLI Pfam PF00929 http://pfam.xfam.org/family/PF00929 Phobius swissprot:EXOX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EXOX_ECOLI PhylomeDB P0AEK0 http://phylomedb.org/?seqid=P0AEK0 ProteinModelPortal P0AEK0 http://www.proteinmodelportal.org/query/uniprot/P0AEK0 PubMed 10514496 http://www.ncbi.nlm.nih.gov/pubmed/10514496 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416358 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416358 RefSeq WP_000944256 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000944256 SMART SM00479 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00479 SMR P0AEK0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEK0 STRING 511145.b1844 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1844&targetmode=cogs STRING COG0847 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0847&targetmode=cogs SUPFAM SSF53098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098 UniProtKB EXOX_ECOLI http://www.uniprot.org/uniprot/EXOX_ECOLI UniProtKB-AC P0AEK0 http://www.uniprot.org/uniprot/P0AEK0 charge swissprot:EXOX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EXOX_ECOLI eggNOG COG0847 http://eggnogapi.embl.de/nog_data/html/tree/COG0847 eggNOG ENOG4105UMD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105UMD epestfind swissprot:EXOX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EXOX_ECOLI garnier swissprot:EXOX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EXOX_ECOLI helixturnhelix swissprot:EXOX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EXOX_ECOLI hmoment swissprot:EXOX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EXOX_ECOLI iep swissprot:EXOX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EXOX_ECOLI inforesidue swissprot:EXOX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EXOX_ECOLI octanol swissprot:EXOX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EXOX_ECOLI pepcoil swissprot:EXOX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EXOX_ECOLI pepdigest swissprot:EXOX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EXOX_ECOLI pepinfo swissprot:EXOX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EXOX_ECOLI pepnet swissprot:EXOX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EXOX_ECOLI pepstats swissprot:EXOX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EXOX_ECOLI pepwheel swissprot:EXOX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EXOX_ECOLI pepwindow swissprot:EXOX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EXOX_ECOLI sigcleave swissprot:EXOX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EXOX_ECOLI ## Database ID URL or Descriptions # BioGrid 4261169 198 # CATALYTIC ACTIVITY AMIC_ECOLI Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. # CDD cd02696 MurNAc-LAA # DISRUPTION PHENOTYPE Mutants are growing in chains of 3 to 6 cells. {ECO:0000269|PubMed 11454209}. # DOMAIN AMIC_ECOLI N-terminal domain is required and sufficient for targeting to the septal ring. {ECO 0000269|PubMed 12787347}. # EcoGene EG13086 amiC # FUNCTION AMIC_ECOLI Cell-wall hydrolase involved in septum cleavage during cell division. Can also act as powerful autolysin in the presence of murein synthesis inhibitors. {ECO 0000269|PubMed 11454209, ECO 0000269|PubMed 18390656}. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_component GO:0042597 periplasmic space; IDA:EcoliWiki. # GO_function GO:0008745 N-acetylmuramoyl-L-alanine amidase activity; IDA:EcoCyc. # GO_process GO:0009253 peptidoglycan catabolic process; IEA:InterPro. # GO_process GO:0043093 FtsZ-dependent cytokinesis; IDA:EcoCyc. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 3.40.630.40 -; 2. # IntAct P63883 2 # InterPro IPR002508 MurNAc-LAA_cat # InterPro IPR006311 TAT_signal # InterPro IPR021731 AMIN_dom # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03036 Chromosome # Organism AMIC_ECOLI Escherichia coli (strain K12) # PATRIC 32121052 VBIEscCol129921_2915 # PDB 4BIN X-ray; 2.49 A; A=35-417 # PROSITE PS51318 TAT # PTM AMIC_ECOLI Exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven. Can also be exported by the Sec system. # Pfam PF01520 Amidase_3 # Pfam PF11741 AMIN # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AMIC_ECOLI N-acetylmuramoyl-L-alanine amidase AmiC # RefSeq NP_417294 NC_000913.3 # RefSeq WP_000016907 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40464.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family. {ECO 0000305}. # SMART SM00646 Ami_3 # SUBCELLULAR LOCATION AMIC_ECOLI Periplasm {ECO 0000269|PubMed 12787347}. Note=Present throughout the periplasm in non-dividing cells, but localizes almost exclusively to a ring at the site of constriction in dividing cells. # eggNOG COG0860 LUCA # eggNOG ENOG4105C5C Bacteria BLAST swissprot:AMIC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AMIC_ECOLI BioCyc ECOL316407:JW5449-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5449-MONOMER BioCyc EcoCyc:G7458-MONOMER http://biocyc.org/getid?id=EcoCyc:G7458-MONOMER BioCyc MetaCyc:G7458-MONOMER http://biocyc.org/getid?id=MetaCyc:G7458-MONOMER COG COG0860 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0860 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2001.02499.x http://dx.doi.org/10.1046/j.1365-2958.2001.02499.x DOI 10.1046/j.1365-2958.2003.03511.x http://dx.doi.org/10.1046/j.1365-2958.2003.03511.x DOI 10.1074/jbc.M610507200 http://dx.doi.org/10.1074/jbc.M610507200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00207-08 http://dx.doi.org/10.1128/JB.00207-08 EC_number EC:3.5.1.28 http://www.genome.jp/dbget-bin/www_bget?EC:3.5.1.28 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 ENZYME 3.5.1.28 http://enzyme.expasy.org/EC/3.5.1.28 EchoBASE EB2895 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2895 EcoGene EG13086 http://www.ecogene.org/geneInfo.php?eg_id=EG13086 EnsemblBacteria AAC75856 http://www.ensemblgenomes.org/id/AAC75856 EnsemblBacteria AAC75856 http://www.ensemblgenomes.org/id/AAC75856 EnsemblBacteria BAE76886 http://www.ensemblgenomes.org/id/BAE76886 EnsemblBacteria BAE76886 http://www.ensemblgenomes.org/id/BAE76886 EnsemblBacteria BAE76886 http://www.ensemblgenomes.org/id/BAE76886 EnsemblBacteria b2817 http://www.ensemblgenomes.org/id/b2817 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0008745 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008745 GO_process GO:0009253 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009253 GO_process GO:0043093 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043093 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 3.40.630.40 http://www.cathdb.info/version/latest/superfamily/3.40.630.40 GeneID 947293 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947293 HOGENOM HOG000263827 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000263827&db=HOGENOM6 InParanoid P63883 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P63883 IntAct P63883 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P63883* IntEnz 3.5.1.28 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.1.28 InterPro IPR002508 http://www.ebi.ac.uk/interpro/entry/IPR002508 InterPro IPR006311 http://www.ebi.ac.uk/interpro/entry/IPR006311 InterPro IPR021731 http://www.ebi.ac.uk/interpro/entry/IPR021731 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene ecj:JW5449 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5449 KEGG_Gene eco:b2817 http://www.genome.jp/dbget-bin/www_bget?eco:b2817 KEGG_Orthology KO:K01448 http://www.genome.jp/dbget-bin/www_bget?KO:K01448 KEGG_Reaction rn:R04112 http://www.genome.jp/dbget-bin/www_bget?rn:R04112 OMA DLYPQEG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DLYPQEG PDB 4BIN http://www.ebi.ac.uk/pdbe-srv/view/entry/4BIN PDBsum 4BIN http://www.ebi.ac.uk/pdbsum/4BIN PROSITE PS51318 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51318 PSORT swissprot:AMIC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AMIC_ECOLI PSORT-B swissprot:AMIC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AMIC_ECOLI PSORT2 swissprot:AMIC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AMIC_ECOLI Pfam PF01520 http://pfam.xfam.org/family/PF01520 Pfam PF11741 http://pfam.xfam.org/family/PF11741 Phobius swissprot:AMIC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AMIC_ECOLI PhylomeDB P63883 http://phylomedb.org/?seqid=P63883 ProteinModelPortal P63883 http://www.proteinmodelportal.org/query/uniprot/P63883 PubMed 11454209 http://www.ncbi.nlm.nih.gov/pubmed/11454209 PubMed 12787347 http://www.ncbi.nlm.nih.gov/pubmed/12787347 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17218314 http://www.ncbi.nlm.nih.gov/pubmed/17218314 PubMed 18390656 http://www.ncbi.nlm.nih.gov/pubmed/18390656 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417294 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417294 RefSeq WP_000016907 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000016907 SMART SM00646 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00646 SMR P63883 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P63883 STRING 511145.b2817 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2817&targetmode=cogs STRING COG0860 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0860&targetmode=cogs UniProtKB AMIC_ECOLI http://www.uniprot.org/uniprot/AMIC_ECOLI UniProtKB-AC P63883 http://www.uniprot.org/uniprot/P63883 charge swissprot:AMIC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AMIC_ECOLI eggNOG COG0860 http://eggnogapi.embl.de/nog_data/html/tree/COG0860 eggNOG ENOG4105C5C http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C5C epestfind swissprot:AMIC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AMIC_ECOLI garnier swissprot:AMIC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AMIC_ECOLI helixturnhelix swissprot:AMIC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AMIC_ECOLI hmoment swissprot:AMIC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AMIC_ECOLI iep swissprot:AMIC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AMIC_ECOLI inforesidue swissprot:AMIC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AMIC_ECOLI octanol swissprot:AMIC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AMIC_ECOLI pepcoil swissprot:AMIC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AMIC_ECOLI pepdigest swissprot:AMIC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AMIC_ECOLI pepinfo swissprot:AMIC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AMIC_ECOLI pepnet swissprot:AMIC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AMIC_ECOLI pepstats swissprot:AMIC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AMIC_ECOLI pepwheel swissprot:AMIC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AMIC_ECOLI pepwindow swissprot:AMIC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AMIC_ECOLI sigcleave swissprot:AMIC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AMIC_ECOLI ## Database ID URL or Descriptions # AltName TILS_ECOLI tRNA(Ile)-2-lysyl-cytidine synthase # AltName TILS_ECOLI tRNA(Ile)-lysidine synthetase # BRENDA 6.3.4.19 2026 # BioGrid 4261685 154 # CATALYTIC ACTIVITY (tRNA(Ile2))-cytidine(34) + L-lysine + ATP = (tRNA(Ile2))-lysidine(34) + AMP + diphosphate + H(2)O. {ECO:0000269|PubMed 14527414}. # CDD cd01992 PP-ATPase # DOMAIN TILS_ECOLI The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding. # EcoGene EG13220 tilS # FUNCTION TILS_ECOLI Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. This enzyme is essential for viability. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0032267 tRNA(Ile)-lysidine synthase activity; IDA:EcoCyc. # GO_process GO:0002136 wobble base lysidine biosynthesis; IMP:EcoCyc. # GO_process GO:0006400 tRNA modification; IDA:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # Gene3D 3.40.50.620 -; 1. # HAMAP MF_01161 tRNA_Ile_lys_synt # INTERACTION TILS_ECOLI Self; NbExp=3; IntAct=EBI-556745, EBI-556745; # IntAct P52097 17 # InterPro IPR011063 TilS/TtcA_N # InterPro IPR012094 tRNA_Ile_lys_synt # InterPro IPR012795 tRNA_Ile_lys_synt_N # InterPro IPR012796 Lysidine-tRNA-synth_C # InterPro IPR014729 Rossmann-like_a/b/a_fold # InterPro IPR015262 tRNA_Ile_lys_synt_subst-bd # InterPro IPR020825 Phe-tRNA_synthase_B3/B4 # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # Organism TILS_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11807:SF2 PTHR11807:SF2 # PATRIC 32115487 VBIEscCol129921_0195 # PDB 1NI5 X-ray; 2.65 A; A=1-432 # PIR D64743 D64743 # Pfam PF01171 ATP_bind_3 # Pfam PF09179 TilS # Pfam PF11734 TilS_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TILS_ECOLI tRNA(Ile)-lysidine synthase # RefSeq NP_414730 NC_000913.3 # RefSeq WP_000176549 NZ_LN832404.1 # SIMILARITY Belongs to the tRNA(Ile)-lysidine synthase family. {ECO 0000305}. # SMART SM00977 TilS_C # SUBCELLULAR LOCATION TILS_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF56037 SSF56037 # TIGRFAMs TIGR02432 lysidine_TilS_N # TIGRFAMs TIGR02433 lysidine_TilS_C # eggNOG COG0037 LUCA # eggNOG ENOG4105D3U Bacteria BLAST swissprot:TILS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TILS_ECOLI BioCyc ECOL316407:JW0183-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0183-MONOMER BioCyc EcoCyc:G6096-MONOMER http://biocyc.org/getid?id=EcoCyc:G6096-MONOMER BioCyc MetaCyc:G6096-MONOMER http://biocyc.org/getid?id=MetaCyc:G6096-MONOMER COG COG0037 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0037 DIP DIP-10190N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10190N DOI 10.1016/S1097-2765(03)00346-0 http://dx.doi.org/10.1016/S1097-2765(03)00346-0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1998.00981.x http://dx.doi.org/10.1046/j.1365-2958.1998.00981.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.3.4.19 http://www.genome.jp/dbget-bin/www_bget?EC:6.3.4.19 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL BR000032 http://www.ebi.ac.uk/ena/data/view/BR000032 EMBL D49445 http://www.ebi.ac.uk/ena/data/view/D49445 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EMBL Z50870 http://www.ebi.ac.uk/ena/data/view/Z50870 ENZYME 6.3.4.19 http://enzyme.expasy.org/EC/6.3.4.19 EchoBASE EB3011 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3011 EcoGene EG13220 http://www.ecogene.org/geneInfo.php?eg_id=EG13220 EnsemblBacteria AAC73299 http://www.ensemblgenomes.org/id/AAC73299 EnsemblBacteria AAC73299 http://www.ensemblgenomes.org/id/AAC73299 EnsemblBacteria BAA77863 http://www.ensemblgenomes.org/id/BAA77863 EnsemblBacteria BAA77863 http://www.ensemblgenomes.org/id/BAA77863 EnsemblBacteria BAA77863 http://www.ensemblgenomes.org/id/BAA77863 EnsemblBacteria b0188 http://www.ensemblgenomes.org/id/b0188 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0032267 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032267 GO_process GO:0002136 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002136 GO_process GO:0006400 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006400 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 GeneID 944889 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944889 HAMAP MF_01161 http://hamap.expasy.org/unirule/MF_01161 HOGENOM HOG000236507 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000236507&db=HOGENOM6 InParanoid P52097 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P52097 IntAct P52097 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P52097* IntEnz 6.3.4.19 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.4.19 InterPro IPR011063 http://www.ebi.ac.uk/interpro/entry/IPR011063 InterPro IPR012094 http://www.ebi.ac.uk/interpro/entry/IPR012094 InterPro IPR012795 http://www.ebi.ac.uk/interpro/entry/IPR012795 InterPro IPR012796 http://www.ebi.ac.uk/interpro/entry/IPR012796 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 InterPro IPR015262 http://www.ebi.ac.uk/interpro/entry/IPR015262 InterPro IPR020825 http://www.ebi.ac.uk/interpro/entry/IPR020825 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW0183 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0183 KEGG_Gene eco:b0188 http://www.genome.jp/dbget-bin/www_bget?eco:b0188 KEGG_Orthology KO:K04075 http://www.genome.jp/dbget-bin/www_bget?KO:K04075 KEGG_Reaction rn:R09597 http://www.genome.jp/dbget-bin/www_bget?rn:R09597 MINT MINT-1261006 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1261006 OMA DRNFLRQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DRNFLRQ PANTHER PTHR11807:SF2 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11807:SF2 PDB 1NI5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1NI5 PDBsum 1NI5 http://www.ebi.ac.uk/pdbsum/1NI5 PSORT swissprot:TILS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TILS_ECOLI PSORT-B swissprot:TILS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TILS_ECOLI PSORT2 swissprot:TILS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TILS_ECOLI Pfam PF01171 http://pfam.xfam.org/family/PF01171 Pfam PF09179 http://pfam.xfam.org/family/PF09179 Pfam PF11734 http://pfam.xfam.org/family/PF11734 Phobius swissprot:TILS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TILS_ECOLI PhylomeDB P52097 http://phylomedb.org/?seqid=P52097 ProteinModelPortal P52097 http://www.proteinmodelportal.org/query/uniprot/P52097 PubMed 14527414 http://www.ncbi.nlm.nih.gov/pubmed/14527414 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9723924 http://www.ncbi.nlm.nih.gov/pubmed/9723924 RefSeq NP_414730 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414730 RefSeq WP_000176549 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000176549 SMART SM00977 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00977 SMR P52097 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P52097 STRING 511145.b0188 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0188&targetmode=cogs STRING COG0037 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0037&targetmode=cogs SUPFAM SSF56037 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56037 TIGRFAMs TIGR02432 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02432 TIGRFAMs TIGR02433 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02433 UniProtKB TILS_ECOLI http://www.uniprot.org/uniprot/TILS_ECOLI UniProtKB-AC P52097 http://www.uniprot.org/uniprot/P52097 charge swissprot:TILS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TILS_ECOLI eggNOG COG0037 http://eggnogapi.embl.de/nog_data/html/tree/COG0037 eggNOG ENOG4105D3U http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D3U epestfind swissprot:TILS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TILS_ECOLI garnier swissprot:TILS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TILS_ECOLI helixturnhelix swissprot:TILS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TILS_ECOLI hmoment swissprot:TILS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TILS_ECOLI iep swissprot:TILS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TILS_ECOLI inforesidue swissprot:TILS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TILS_ECOLI octanol swissprot:TILS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TILS_ECOLI pepcoil swissprot:TILS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TILS_ECOLI pepdigest swissprot:TILS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TILS_ECOLI pepinfo swissprot:TILS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TILS_ECOLI pepnet swissprot:TILS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TILS_ECOLI pepstats swissprot:TILS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TILS_ECOLI pepwheel swissprot:TILS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TILS_ECOLI pepwindow swissprot:TILS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TILS_ECOLI sigcleave swissprot:TILS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TILS_ECOLI ## Database ID URL or Descriptions # BioGrid 4260763 95 # EcoGene EG12916 yhfU # InterPro IPR021238 DUF2620 # Organism YHFU_ECOLI Escherichia coli (strain K12) # PATRIC 32122188 VBIEscCol129921_3471 # PIR E65132 E65132 # Pfam PF10941 DUF2620 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHFU_ECOLI Uncharacterized protein YhfU # RefSeq NP_417837 NC_000913.3 # RefSeq WP_000719728 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA58175.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # eggNOG ENOG4105MUZ Bacteria # eggNOG ENOG4111VTB LUCA BLAST swissprot:YHFU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHFU_ECOLI BioCyc ECOL316407:JW5697-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5697-MONOMER BioCyc EcoCyc:G7730-MONOMER http://biocyc.org/getid?id=EcoCyc:G7730-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2752 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2752 EcoGene EG12916 http://www.ecogene.org/geneInfo.php?eg_id=EG12916 EnsemblBacteria AAC76403 http://www.ensemblgenomes.org/id/AAC76403 EnsemblBacteria AAC76403 http://www.ensemblgenomes.org/id/AAC76403 EnsemblBacteria BAE77913 http://www.ensemblgenomes.org/id/BAE77913 EnsemblBacteria BAE77913 http://www.ensemblgenomes.org/id/BAE77913 EnsemblBacteria BAE77913 http://www.ensemblgenomes.org/id/BAE77913 EnsemblBacteria b3378 http://www.ensemblgenomes.org/id/b3378 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947892 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947892 HOGENOM HOG000125464 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125464&db=HOGENOM6 IntAct P64631 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P64631* InterPro IPR021238 http://www.ebi.ac.uk/interpro/entry/IPR021238 KEGG_Gene ecj:JW5697 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5697 KEGG_Gene eco:b3378 http://www.genome.jp/dbget-bin/www_bget?eco:b3378 OMA YLGACNT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YLGACNT PSORT swissprot:YHFU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHFU_ECOLI PSORT-B swissprot:YHFU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHFU_ECOLI PSORT2 swissprot:YHFU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHFU_ECOLI Pfam PF10941 http://pfam.xfam.org/family/PF10941 Phobius swissprot:YHFU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHFU_ECOLI ProteinModelPortal P64631 http://www.proteinmodelportal.org/query/uniprot/P64631 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417837 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417837 RefSeq WP_000719728 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000719728 STRING 511145.b3378 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3378&targetmode=cogs UniProtKB YHFU_ECOLI http://www.uniprot.org/uniprot/YHFU_ECOLI UniProtKB-AC P64631 http://www.uniprot.org/uniprot/P64631 charge swissprot:YHFU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHFU_ECOLI eggNOG ENOG4105MUZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105MUZ eggNOG ENOG4111VTB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111VTB epestfind swissprot:YHFU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHFU_ECOLI garnier swissprot:YHFU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHFU_ECOLI helixturnhelix swissprot:YHFU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHFU_ECOLI hmoment swissprot:YHFU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHFU_ECOLI iep swissprot:YHFU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHFU_ECOLI inforesidue swissprot:YHFU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHFU_ECOLI octanol swissprot:YHFU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHFU_ECOLI pepcoil swissprot:YHFU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHFU_ECOLI pepdigest swissprot:YHFU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHFU_ECOLI pepinfo swissprot:YHFU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHFU_ECOLI pepnet swissprot:YHFU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHFU_ECOLI pepstats swissprot:YHFU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHFU_ECOLI pepwheel swissprot:YHFU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHFU_ECOLI pepwindow swissprot:YHFU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHFU_ECOLI sigcleave swissprot:YHFU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHFU_ECOLI ## Database ID URL or Descriptions # AltName BCP_ECOLI Bacterioferritin comigratory protein # AltName BCP_ECOLI Thioredoxin reductase # BioGrid 4260768 12 # CATALYTIC ACTIVITY BCP_ECOLI 2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH. # EcoGene EG10108 bcp # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008379 thioredoxin peroxidase activity; IDA:EcoCyc. # GO_function GO:0032843 hydroperoxide reductase activity; IDA:EcoCyc. # GO_process GO:0006979 response to oxidative stress; IMP:EcoCyc. # GO_process GO:0045454 cell redox homeostasis; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006950 response to stress # GOslim_process GO:0042592 homeostatic process # Gene3D 3.40.30.10 -; 1. # IntAct P0AE52 7 # InterPro IPR000866 AhpC/TSA # InterPro IPR012336 Thioredoxin-like_fold # InterPro IPR013766 Thioredoxin_domain # InterPro IPR024706 Peroxiredoxin_AhpC-typ # KEGG_Brite ko01000 Enzymes # Organism BCP_ECOLI Escherichia coli (strain K12) # PATRIC 32120347 VBIEscCol129921_2576 # PIR B49749 B49749 # PIRSF PIRSF000239 AHPC # PROSITE PS51352 THIOREDOXIN_2 # Pfam PF00578 AhpC-TSA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BCP_ECOLI Putative peroxiredoxin bcp # RefSeq NP_416975 NC_000913.3 # RefSeq WP_001068682 NZ_LN832404.1 # SIMILARITY Belongs to the AhpC/TSA family. {ECO 0000305}. # SIMILARITY Contains 1 thioredoxin domain. {ECO:0000255|PROSITE- ProRule PRU00691}. # SUPFAM SSF52833 SSF52833 # eggNOG COG1225 LUCA # eggNOG ENOG4108YXY Bacteria BLAST swissprot:BCP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BCP_ECOLI BioCyc ECOL316407:JW2465-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2465-MONOMER BioCyc EcoCyc:EG10108-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10108-MONOMER BioCyc MetaCyc:EG10108-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10108-MONOMER COG COG1225 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1225 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.275.4.2924 http://dx.doi.org/10.1074/jbc.275.4.2924 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1099/00221287-137-2-361 http://dx.doi.org/10.1099/00221287-137-2-361 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.11.1.15 http://www.genome.jp/dbget-bin/www_bget?EC:1.11.1.15 EMBL AF023337 http://www.ebi.ac.uk/ena/data/view/AF023337 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M63654 http://www.ebi.ac.uk/ena/data/view/M63654 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.11.1.15 http://enzyme.expasy.org/EC/1.11.1.15 EchoBASE EB0106 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0106 EcoGene EG10108 http://www.ecogene.org/geneInfo.php?eg_id=EG10108 EnsemblBacteria AAC75533 http://www.ensemblgenomes.org/id/AAC75533 EnsemblBacteria AAC75533 http://www.ensemblgenomes.org/id/AAC75533 EnsemblBacteria BAA16358 http://www.ensemblgenomes.org/id/BAA16358 EnsemblBacteria BAA16358 http://www.ensemblgenomes.org/id/BAA16358 EnsemblBacteria BAA16358 http://www.ensemblgenomes.org/id/BAA16358 EnsemblBacteria b2480 http://www.ensemblgenomes.org/id/b2480 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008379 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008379 GO_function GO:0032843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032843 GO_process GO:0006979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979 GO_process GO:0045454 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045454 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 Gene3D 3.40.30.10 http://www.cathdb.info/version/latest/superfamily/3.40.30.10 GeneID 946949 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946949 HOGENOM HOG000022344 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000022344&db=HOGENOM6 InParanoid P0AE52 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AE52 IntAct P0AE52 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AE52* IntEnz 1.11.1.15 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.11.1.15 InterPro IPR000866 http://www.ebi.ac.uk/interpro/entry/IPR000866 InterPro IPR012336 http://www.ebi.ac.uk/interpro/entry/IPR012336 InterPro IPR013766 http://www.ebi.ac.uk/interpro/entry/IPR013766 InterPro IPR024706 http://www.ebi.ac.uk/interpro/entry/IPR024706 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2465 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2465 KEGG_Gene eco:b2480 http://www.genome.jp/dbget-bin/www_bget?eco:b2480 KEGG_Orthology KO:K03564 http://www.genome.jp/dbget-bin/www_bget?KO:K03564 OMA CSTQACD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CSTQACD PROSITE PS51352 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51352 PSORT swissprot:BCP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BCP_ECOLI PSORT-B swissprot:BCP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BCP_ECOLI PSORT2 swissprot:BCP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BCP_ECOLI Pfam PF00578 http://pfam.xfam.org/family/PF00578 Phobius swissprot:BCP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BCP_ECOLI PhylomeDB P0AE52 http://phylomedb.org/?seqid=P0AE52 ProteinModelPortal P0AE52 http://www.proteinmodelportal.org/query/uniprot/P0AE52 PubMed 10644761 http://www.ncbi.nlm.nih.gov/pubmed/10644761 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2016588 http://www.ncbi.nlm.nih.gov/pubmed/2016588 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9537378 http://www.ncbi.nlm.nih.gov/pubmed/9537378 RefSeq NP_416975 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416975 RefSeq WP_001068682 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001068682 SMR P0AE52 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AE52 STRING 511145.b2480 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2480&targetmode=cogs STRING COG1225 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1225&targetmode=cogs SUPFAM SSF52833 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52833 SWISS-2DPAGE P0AE52 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AE52 UniProtKB BCP_ECOLI http://www.uniprot.org/uniprot/BCP_ECOLI UniProtKB-AC P0AE52 http://www.uniprot.org/uniprot/P0AE52 charge swissprot:BCP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BCP_ECOLI eggNOG COG1225 http://eggnogapi.embl.de/nog_data/html/tree/COG1225 eggNOG ENOG4108YXY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108YXY epestfind swissprot:BCP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BCP_ECOLI garnier swissprot:BCP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BCP_ECOLI helixturnhelix swissprot:BCP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BCP_ECOLI hmoment swissprot:BCP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BCP_ECOLI iep swissprot:BCP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BCP_ECOLI inforesidue swissprot:BCP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BCP_ECOLI octanol swissprot:BCP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BCP_ECOLI pepcoil swissprot:BCP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BCP_ECOLI pepdigest swissprot:BCP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BCP_ECOLI pepinfo swissprot:BCP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BCP_ECOLI pepnet swissprot:BCP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BCP_ECOLI pepstats swissprot:BCP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BCP_ECOLI pepwheel swissprot:BCP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BCP_ECOLI pepwindow swissprot:BCP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BCP_ECOLI sigcleave swissprot:BCP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BCP_ECOLI ## Database ID URL or Descriptions # BioGrid 4260688 280 # EcoGene EG13876 mdoC # FUNCTION OPGC_ECOLI Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0016741 transferase activity, transferring one-carbon groups; IEA:UniProtKB-HAMAP. # GO_function GO:0016748 succinyltransferase activity; IMP:EcoCyc. # GO_process GO:0009250 glucan biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0009311 oligosaccharide metabolic process; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # HAMAP MF_01066 MdoC_OpgC # InterPro IPR002656 Acyl_transf_3 # InterPro IPR023723 Glucans_biosynth_C # KEGG_Brite ko01000 Enzymes # Organism OPGC_ECOLI Escherichia coli (strain K12) # PATHWAY OPGC_ECOLI Glycan metabolism; osmoregulated periplasmic glucan (OPG) biosynthesis. # PATRIC 32117331 VBIEscCol129921_1088 # PIR D64847 D64847 # Pfam PF01757 Acyl_transf_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName OPGC_ECOLI Glucans biosynthesis protein C # RefSeq NP_415565 NC_000913.3 # RefSeq WP_001070375 NZ_LN832404.1 # SIMILARITY Belongs to the acyltransferase 3 family. OpgC subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION OPGC_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # eggNOG ENOG4105EIK Bacteria # eggNOG ENOG410ZVNJ LUCA BLAST swissprot:OPGC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:OPGC_ECOLI BioCyc ECOL316407:JW1034-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1034-MONOMER BioCyc EcoCyc:G6552-MONOMER http://biocyc.org/getid?id=EcoCyc:G6552-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.-.- http://www.genome.jp/dbget-bin/www_bget?EC:2.1.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.1.-.- http://enzyme.expasy.org/EC/2.1.-.- EchoBASE EB3635 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3635 EcoGene EG13876 http://www.ecogene.org/geneInfo.php?eg_id=EG13876 EnsemblBacteria AAC74131 http://www.ensemblgenomes.org/id/AAC74131 EnsemblBacteria AAC74131 http://www.ensemblgenomes.org/id/AAC74131 EnsemblBacteria BAA35837 http://www.ensemblgenomes.org/id/BAA35837 EnsemblBacteria BAA35837 http://www.ensemblgenomes.org/id/BAA35837 EnsemblBacteria BAA35837 http://www.ensemblgenomes.org/id/BAA35837 EnsemblBacteria b1047 http://www.ensemblgenomes.org/id/b1047 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0016741 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016741 GO_function GO:0016748 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016748 GO_process GO:0009250 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009250 GO_process GO:0009311 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009311 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 946944 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946944 HAMAP MF_01066 http://hamap.expasy.org/unirule/MF_01066 HOGENOM HOG000219329 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219329&db=HOGENOM6 InParanoid P75920 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75920 IntEnz 2.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1 InterPro IPR002656 http://www.ebi.ac.uk/interpro/entry/IPR002656 InterPro IPR023723 http://www.ebi.ac.uk/interpro/entry/IPR023723 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1034 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1034 KEGG_Gene eco:b1047 http://www.genome.jp/dbget-bin/www_bget?eco:b1047 KEGG_Orthology KO:K11941 http://www.genome.jp/dbget-bin/www_bget?KO:K11941 OMA YFSYMLY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YFSYMLY PSORT swissprot:OPGC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:OPGC_ECOLI PSORT-B swissprot:OPGC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:OPGC_ECOLI PSORT2 swissprot:OPGC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:OPGC_ECOLI Pfam PF01757 http://pfam.xfam.org/family/PF01757 Phobius swissprot:OPGC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:OPGC_ECOLI ProteinModelPortal P75920 http://www.proteinmodelportal.org/query/uniprot/P75920 PubMed 10368134 http://www.ncbi.nlm.nih.gov/pubmed/10368134 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415565 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415565 RefSeq WP_001070375 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001070375 STRING 511145.b1047 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1047&targetmode=cogs UniProtKB OPGC_ECOLI http://www.uniprot.org/uniprot/OPGC_ECOLI UniProtKB-AC P75920 http://www.uniprot.org/uniprot/P75920 charge swissprot:OPGC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:OPGC_ECOLI eggNOG ENOG4105EIK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EIK eggNOG ENOG410ZVNJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZVNJ epestfind swissprot:OPGC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:OPGC_ECOLI garnier swissprot:OPGC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:OPGC_ECOLI helixturnhelix swissprot:OPGC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:OPGC_ECOLI hmoment swissprot:OPGC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:OPGC_ECOLI iep swissprot:OPGC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:OPGC_ECOLI inforesidue swissprot:OPGC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:OPGC_ECOLI octanol swissprot:OPGC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:OPGC_ECOLI pepcoil swissprot:OPGC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:OPGC_ECOLI pepdigest swissprot:OPGC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:OPGC_ECOLI pepinfo swissprot:OPGC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:OPGC_ECOLI pepnet swissprot:OPGC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:OPGC_ECOLI pepstats swissprot:OPGC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:OPGC_ECOLI pepwheel swissprot:OPGC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:OPGC_ECOLI pepwindow swissprot:OPGC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:OPGC_ECOLI sigcleave swissprot:OPGC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:OPGC_ECOLI ## Database ID URL or Descriptions # AltName RLME_ECOLI 23S rRNA Um2552 methyltransferase # AltName RLME_ECOLI Cell division protein FtsJ # AltName RLME_ECOLI rRNA (uridine-2'-O-)-methyltransferase # BIOPHYSICOCHEMICAL PROPERTIES RLME_ECOLI Kinetic parameters KM=0.8 uM for 23S rRNA within 50S ribosomal subunits {ECO 0000269|PubMed 12181314}; KM=3.7 uM for S-adenosyl-L-methionine {ECO 0000269|PubMed 12181314}; Temperature dependence Optimum temperature is 55 degrees Celsius. {ECO 0000269|PubMed 12181314}; # BioGrid 4262423 219 # CATALYTIC ACTIVITY S-adenosyl-L-methionine + uridine(2552) in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methyluridine(2552) in 23S rRNA. {ECO:0000269|PubMed 10748051}. # COFACTOR RLME_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 10748051}; # DISRUPTION PHENOTYPE RLME_ECOLI Cells lacking this gene show a dramatically altered ribosome profile, a severe growth disadvantage, and a temperature-sensitive phenotype. These effects are overcome by overexpressing either of 2 small GTPases, ObgE/CgtA or EngA. {ECO 0000269|PubMed 10983982, ECO 0000269|PubMed 11976298}. # EcoGene EG11507 rlmE # FUNCTION RLME_ECOLI Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. {ECO 0000269|PubMed 10748051}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008650 rRNA (uridine-2'-O-)-methyltransferase activity; IDA:EcoCyc. # GO_process GO:0000027 ribosomal large subunit assembly; IDA:EcoCyc. # GO_process GO:0000453 enzyme-directed rRNA 2'-O-methylation; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0022618 ribonucleoprotein complex assembly # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.50.150 -; 1. # HAMAP MF_01547 RNA_methyltr_E # INDUCTION RLME_ECOLI By heat shock. # IntAct P0C0R7 21 # InterPro IPR002877 rRNA_MeTrfase_FtsJ_dom # InterPro IPR004512 rRNA_MeTrfase_gammaproteobac # InterPro IPR015507 rRNA-MeTfrase_E # InterPro IPR029063 SAM-dependent_MTases # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # Organism RLME_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10920 PTHR10920 # PATRIC 32121776 VBIEscCol129921_3272 # PDB 1EIZ X-ray; 1.70 A; A=30-209 # PDB 1EJ0 X-ray; 1.50 A; A=30-209 # PIR S35108 S35108 # PIRSF PIRSF005461 23S_rRNA_mtase # Pfam PF01728 FtsJ # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RLME_ECOLI Ribosomal RNA large subunit methyltransferase E # RefSeq NP_417646 NC_000913.3 # RefSeq WP_000145975 NZ_LN832404.1 # SIMILARITY Belongs to the methyltransferase superfamily. RlmE family. {ECO 0000305}. # SUBCELLULAR LOCATION RLME_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF53335 SSF53335 # TIGRFAMs TIGR00438 rrmJ # eggNOG COG0293 LUCA # eggNOG ENOG4105F7M Bacteria BLAST swissprot:RLME_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RLME_ECOLI BioCyc ECOL316407:JW3146-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3146-MONOMER BioCyc EcoCyc:EG11507-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11507-MONOMER BioCyc MetaCyc:EG11507-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11507-MONOMER COG COG0293 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0293 DIP DIP-47902N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47902N DOI 10.1006/bbrc.2000.2702 http://dx.doi.org/10.1006/bbrc.2000.2702 DOI 10.1016/S1097-2765(00)00035-6 http://dx.doi.org/10.1016/S1097-2765(00)00035-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M001854200 http://dx.doi.org/10.1074/jbc.M001854200 DOI 10.1074/jbc.M205423200 http://dx.doi.org/10.1074/jbc.M205423200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.10.2692-2698.2002 http://dx.doi.org/10.1128/JB.184.10.2692-2698.2002 DOI 10.1128/JB.186.19.6634-6642.2004 http://dx.doi.org/10.1128/JB.186.19.6634-6642.2004 EC_number EC:2.1.1.166 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.166 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M83138 http://www.ebi.ac.uk/ena/data/view/M83138 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U01376 http://www.ebi.ac.uk/ena/data/view/U01376 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 2.1.1.166 http://enzyme.expasy.org/EC/2.1.1.166 EchoBASE EB1470 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1470 EcoGene EG11507 http://www.ecogene.org/geneInfo.php?eg_id=EG11507 EnsemblBacteria AAC76211 http://www.ensemblgenomes.org/id/AAC76211 EnsemblBacteria AAC76211 http://www.ensemblgenomes.org/id/AAC76211 EnsemblBacteria BAE77223 http://www.ensemblgenomes.org/id/BAE77223 EnsemblBacteria BAE77223 http://www.ensemblgenomes.org/id/BAE77223 EnsemblBacteria BAE77223 http://www.ensemblgenomes.org/id/BAE77223 EnsemblBacteria b3179 http://www.ensemblgenomes.org/id/b3179 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008650 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008650 GO_process GO:0000027 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000027 GO_process GO:0000453 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000453 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0022618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022618 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 GeneID 947689 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947689 HAMAP MF_01547 http://hamap.expasy.org/unirule/MF_01547 HOGENOM HOG000162367 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000162367&db=HOGENOM6 InParanoid P0C0R7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0C0R7 IntAct P0C0R7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0C0R7* IntEnz 2.1.1.166 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.166 InterPro IPR002877 http://www.ebi.ac.uk/interpro/entry/IPR002877 InterPro IPR004512 http://www.ebi.ac.uk/interpro/entry/IPR004512 InterPro IPR015507 http://www.ebi.ac.uk/interpro/entry/IPR015507 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW3146 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3146 KEGG_Gene eco:b3179 http://www.genome.jp/dbget-bin/www_bget?eco:b3179 KEGG_Orthology KO:K02427 http://www.genome.jp/dbget-bin/www_bget?KO:K02427 MINT MINT-1257637 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1257637 OMA IDIPRAM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IDIPRAM PANTHER PTHR10920 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10920 PDB 1EIZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1EIZ PDB 1EJ0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1EJ0 PDBsum 1EIZ http://www.ebi.ac.uk/pdbsum/1EIZ PDBsum 1EJ0 http://www.ebi.ac.uk/pdbsum/1EJ0 PSORT swissprot:RLME_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RLME_ECOLI PSORT-B swissprot:RLME_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RLME_ECOLI PSORT2 swissprot:RLME_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RLME_ECOLI Pfam PF01728 http://pfam.xfam.org/family/PF01728 Phobius swissprot:RLME_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RLME_ECOLI PhylomeDB P0C0R7 http://phylomedb.org/?seqid=P0C0R7 ProteinModelPortal P0C0R7 http://www.proteinmodelportal.org/query/uniprot/P0C0R7 PubMed 10748051 http://www.ncbi.nlm.nih.gov/pubmed/10748051 PubMed 10814528 http://www.ncbi.nlm.nih.gov/pubmed/10814528 PubMed 10983982 http://www.ncbi.nlm.nih.gov/pubmed/10983982 PubMed 11976298 http://www.ncbi.nlm.nih.gov/pubmed/11976298 PubMed 12181314 http://www.ncbi.nlm.nih.gov/pubmed/12181314 PubMed 15375145 http://www.ncbi.nlm.nih.gov/pubmed/15375145 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8444796 http://www.ncbi.nlm.nih.gov/pubmed/8444796 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417646 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417646 RefSeq WP_000145975 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000145975 SMR P0C0R7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0C0R7 STRING 511145.b3179 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3179&targetmode=cogs STRING COG0293 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0293&targetmode=cogs SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 TIGRFAMs TIGR00438 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00438 UniProtKB RLME_ECOLI http://www.uniprot.org/uniprot/RLME_ECOLI UniProtKB-AC P0C0R7 http://www.uniprot.org/uniprot/P0C0R7 charge swissprot:RLME_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RLME_ECOLI eggNOG COG0293 http://eggnogapi.embl.de/nog_data/html/tree/COG0293 eggNOG ENOG4105F7M http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F7M epestfind swissprot:RLME_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RLME_ECOLI garnier swissprot:RLME_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RLME_ECOLI helixturnhelix swissprot:RLME_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RLME_ECOLI hmoment swissprot:RLME_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RLME_ECOLI iep swissprot:RLME_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RLME_ECOLI inforesidue swissprot:RLME_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RLME_ECOLI octanol swissprot:RLME_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RLME_ECOLI pepcoil swissprot:RLME_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RLME_ECOLI pepdigest swissprot:RLME_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RLME_ECOLI pepinfo swissprot:RLME_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RLME_ECOLI pepnet swissprot:RLME_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RLME_ECOLI pepstats swissprot:RLME_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RLME_ECOLI pepwheel swissprot:RLME_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RLME_ECOLI pepwindow swissprot:RLME_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RLME_ECOLI sigcleave swissprot:RLME_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RLME_ECOLI ## Database ID URL or Descriptions # BRENDA 5.3.1.14 2026 # CATALYTIC ACTIVITY RHAA_ECOLI L-rhamnopyranose = L-rhamnulose. # COFACTOR Name=Mn(2+); Xref=ChEBI:CHEBI 29035; Note=Binds 1 Mn(2+) ion per subunit.; # EcoGene EG11867 rhaA # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0008740 L-rhamnose isomerase activity; IDA:EcoCyc. # GO_function GO:0030145 manganese ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0019301 rhamnose catabolic process; IMP:EcoCyc. # GO_process GO:0019324 L-lyxose metabolic process; IEP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.150 -; 1. # HAMAP MF_00541 RhaA # INDUCTION RHAA_ECOLI Induced by L-rhamnose via the RhaR-RhaS regulatory cascade. Binding of the cAMP receptor protein (CRP) is required for full expression. {ECO 0000269|PubMed 10852886, ECO 0000269|PubMed 8230210}. # InterPro IPR009308 Rhamnose_isomerase # InterPro IPR013022 Xyl_isomerase-like_TIM-brl # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00051 Fructose and mannose metabolism # MISCELLANEOUS RHAA_ECOLI In the crystal structure, RhaA appears to bind a zinc ion at a structural site. However, the metal ion may be different in vivo. # Organism RHAA_ECOLI Escherichia coli (strain K12) # PATHWAY Carbohydrate degradation; L-rhamnose degradation; glycerone phosphate from L-rhamnose step 1/3. # PATRIC 32123315 VBIEscCol129921_4018 # PDB 1D8W X-ray; 1.60 A; A/B/C/D=1-419 # PDB 1DE5 X-ray; 2.20 A; A/B/C/D=1-419 # PDB 1DE6 X-ray; 2.10 A; A/B/C/D=1-419 # PIR S40847 S40847 # Pfam PF06134 RhaA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RHAA_ECOLI L-rhamnose isomerase # RefSeq WP_001311268 NZ_LN832404.1 # RefSeq YP_026276 NC_000913.3 # SIMILARITY Belongs to the rhamnose isomerase family. {ECO 0000305}. # SUBCELLULAR LOCATION RHAA_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Homotetramer. {ECO:0000269|PubMed 10891278}. # SUPFAM SSF51658 SSF51658 # TIGRFAMs TIGR01748 rhaA # UniPathway UPA00541 UER00601 # eggNOG COG4806 LUCA # eggNOG ENOG4105DKG Bacteria BLAST swissprot:RHAA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RHAA_ECOLI BioCyc ECOL316407:JW5561-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5561-MONOMER BioCyc EcoCyc:RHAMNISOM-MONOMER http://biocyc.org/getid?id=EcoCyc:RHAMNISOM-MONOMER BioCyc MetaCyc:RHAMNISOM-MONOMER http://biocyc.org/getid?id=MetaCyc:RHAMNISOM-MONOMER DIP DIP-10690N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10690N DOI 10.1006/jmbi.1993.1565 http://dx.doi.org/10.1006/jmbi.1993.1565 DOI 10.1006/jmbi.2000.3896 http://dx.doi.org/10.1006/jmbi.2000.3896 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.12.3529-3535.2000 http://dx.doi.org/10.1128/JB.182.12.3529-3535.2000 DisProt DP00429 http://www.disprot.org/protein.php?id=DP00429 EC_number EC:5.3.1.14 http://www.genome.jp/dbget-bin/www_bget?EC:5.3.1.14 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X60472 http://www.ebi.ac.uk/ena/data/view/X60472 ENZYME 5.3.1.14 http://enzyme.expasy.org/EC/5.3.1.14 EchoBASE EB1813 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1813 EcoGene EG11867 http://www.ecogene.org/geneInfo.php?eg_id=EG11867 EnsemblBacteria AAT48234 http://www.ensemblgenomes.org/id/AAT48234 EnsemblBacteria AAT48234 http://www.ensemblgenomes.org/id/AAT48234 EnsemblBacteria BAE77406 http://www.ensemblgenomes.org/id/BAE77406 EnsemblBacteria BAE77406 http://www.ensemblgenomes.org/id/BAE77406 EnsemblBacteria BAE77406 http://www.ensemblgenomes.org/id/BAE77406 EnsemblBacteria b3903 http://www.ensemblgenomes.org/id/b3903 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0008740 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008740 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0019301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019301 GO_process GO:0019324 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019324 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.150 http://www.cathdb.info/version/latest/superfamily/3.20.20.150 GeneID 948400 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948400 HAMAP MF_00541 http://hamap.expasy.org/unirule/MF_00541 HOGENOM HOG000269679 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000269679&db=HOGENOM6 InParanoid P32170 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32170 IntEnz 5.3.1.14 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.3.1.14 InterPro IPR009308 http://www.ebi.ac.uk/interpro/entry/IPR009308 InterPro IPR013022 http://www.ebi.ac.uk/interpro/entry/IPR013022 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5561 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5561 KEGG_Gene eco:b3903 http://www.genome.jp/dbget-bin/www_bget?eco:b3903 KEGG_Orthology KO:K01813 http://www.genome.jp/dbget-bin/www_bget?KO:K01813 KEGG_Pathway ko00051 http://www.genome.jp/kegg-bin/show_pathway?ko00051 KEGG_Reaction rn:R02437 http://www.genome.jp/dbget-bin/www_bget?rn:R02437 OMA VNLHAIY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VNLHAIY PDB 1D8W http://www.ebi.ac.uk/pdbe-srv/view/entry/1D8W PDB 1DE5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1DE5 PDB 1DE6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1DE6 PDBsum 1D8W http://www.ebi.ac.uk/pdbsum/1D8W PDBsum 1DE5 http://www.ebi.ac.uk/pdbsum/1DE5 PDBsum 1DE6 http://www.ebi.ac.uk/pdbsum/1DE6 PSORT swissprot:RHAA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RHAA_ECOLI PSORT-B swissprot:RHAA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RHAA_ECOLI PSORT2 swissprot:RHAA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RHAA_ECOLI Pfam PF06134 http://pfam.xfam.org/family/PF06134 Phobius swissprot:RHAA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RHAA_ECOLI PhylomeDB P32170 http://phylomedb.org/?seqid=P32170 ProteinModelPortal P32170 http://www.proteinmodelportal.org/query/uniprot/P32170 PubMed 10852886 http://www.ncbi.nlm.nih.gov/pubmed/10852886 PubMed 10891278 http://www.ncbi.nlm.nih.gov/pubmed/10891278 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8230210 http://www.ncbi.nlm.nih.gov/pubmed/8230210 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 8396120 http://www.ncbi.nlm.nih.gov/pubmed/8396120 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001311268 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001311268 RefSeq YP_026276 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026276 SMR P32170 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32170 STRING 511145.b3903 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3903&targetmode=cogs SUPFAM SSF51658 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51658 TIGRFAMs TIGR01748 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01748 UniProtKB RHAA_ECOLI http://www.uniprot.org/uniprot/RHAA_ECOLI UniProtKB-AC P32170 http://www.uniprot.org/uniprot/P32170 charge swissprot:RHAA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RHAA_ECOLI eggNOG COG4806 http://eggnogapi.embl.de/nog_data/html/tree/COG4806 eggNOG ENOG4105DKG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DKG epestfind swissprot:RHAA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RHAA_ECOLI garnier swissprot:RHAA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RHAA_ECOLI helixturnhelix swissprot:RHAA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RHAA_ECOLI hmoment swissprot:RHAA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RHAA_ECOLI iep swissprot:RHAA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RHAA_ECOLI inforesidue swissprot:RHAA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RHAA_ECOLI octanol swissprot:RHAA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RHAA_ECOLI pepcoil swissprot:RHAA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RHAA_ECOLI pepdigest swissprot:RHAA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RHAA_ECOLI pepinfo swissprot:RHAA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RHAA_ECOLI pepnet swissprot:RHAA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RHAA_ECOLI pepstats swissprot:RHAA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RHAA_ECOLI pepwheel swissprot:RHAA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RHAA_ECOLI pepwindow swissprot:RHAA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RHAA_ECOLI sigcleave swissprot:RHAA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RHAA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261785 6 # CAUTION Although it was initially thought to be a methyltransferase of the menaquinone pathway, PubMed:13678585 showed that it has no SAM-dependent methyltransferase activity and is not involved in the menaquinone pathway. {ECO 0000305}. # EcoGene EG11879 rraA # FUNCTION RRAA_ECOLI Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome. {ECO 0000269|PubMed 13678585, ECO 0000269|PubMed 16725107, ECO 0000269|PubMed 16771842, ECO 0000269|PubMed 18510556, ECO 0000269|PubMed 20106955}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008428 ribonuclease inhibitor activity; IDA:EcoCyc. # GO_function GO:0060698 endoribonuclease inhibitor activity; IEA:UniProtKB-HAMAP. # GO_process GO:0006401 RNA catabolic process; IDA:EcoCyc. # GO_process GO:0060702 negative regulation of endoribonuclease activity; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0030234 enzyme regulator activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # Gene3D 3.50.30.40 -; 1. # HAMAP MF_00471 RraA # INDUCTION Induced upon entry into stationary phase, in a RpoS- dependent manner. Stability of the rraA transcript is Rne dependent, suggesting the existence of a feedback mechanism in the regulation of RraA level. {ECO:0000269|PubMed 16621818}. # IntAct P0A8R0 12 # InterPro IPR005493 RraA/RraA-like # InterPro IPR010203 RraA # InterPro IPR014339 RraA_gpbac # MISCELLANEOUS RRAA_ECOLI RraA and RraB interact with Rne at separate sites within the Rne and exert distinct effects on the composition of the degradosome, affecting distinct sets of RNA transcripts. # Organism RRAA_ECOLI Escherichia coli (strain K12) # PATRIC 32123373 VBIEscCol129921_4047 # PDB 1Q5X X-ray; 2.00 A; A/B/C=1-161 # PDB 2YJT X-ray; 2.90 A; A/B/C=1-161 # PDB 2YJV X-ray; 2.80 A; A/B/C/D/E/F/G/H/I/J/K/L=1-161 # PIR S40872 S40872 # Pfam PF03737 Methyltransf_6 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RRAA_ECOLI Regulator of ribonuclease activity A # RefSeq NP_418364 NC_000913.3 # RefSeq WP_000872908 NZ_LN832404.1 # SIMILARITY Belongs to the RraA family. {ECO 0000305}. # SUBCELLULAR LOCATION RRAA_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Homotrimer. Forms a ring-like structure with a central cavity. Binds to both RNA-binding sites in the C-terminal region of Rne and to RhlB. {ECO:0000269|PubMed 14499605}. # SUPFAM SSF89562 SSF89562 # TIGRFAMs TIGR01935 NOT-MenG # TIGRFAMs TIGR02998 RraA_entero # eggNOG COG0684 LUCA # eggNOG ENOG4108YYX Bacteria BLAST swissprot:RRAA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RRAA_ECOLI BioCyc ECOL316407:JW3900-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3900-MONOMER BioCyc EcoCyc:EG11879-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11879-MONOMER COG COG0684 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0684 DIP DIP-35864N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35864N DOI 10.1016/S0022-2836(03)00970-7 http://dx.doi.org/10.1016/S0022-2836(03)00970-7 DOI 10.1016/j.bbrc.2006.05.018 http://dx.doi.org/10.1016/j.bbrc.2006.05.018 DOI 10.1016/j.cell.2003.08.003 http://dx.doi.org/10.1016/j.cell.2003.08.003 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1111/j.1365-2958.2006.05246.x http://dx.doi.org/10.1111/j.1365-2958.2006.05246.x DOI 10.1111/j.1574-6968.2008.01205.x http://dx.doi.org/10.1111/j.1574-6968.2008.01205.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.188.9.3257-3263.2006 http://dx.doi.org/10.1128/JB.188.9.3257-3263.2006 DOI 10.1261/rna.1858010 http://dx.doi.org/10.1261/rna.1858010 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U56082 http://www.ebi.ac.uk/ena/data/view/U56082 EchoBASE EB1825 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1825 EcoGene EG11879 http://www.ecogene.org/geneInfo.php?eg_id=EG11879 EnsemblBacteria AAC76911 http://www.ensemblgenomes.org/id/AAC76911 EnsemblBacteria AAC76911 http://www.ensemblgenomes.org/id/AAC76911 EnsemblBacteria BAE77381 http://www.ensemblgenomes.org/id/BAE77381 EnsemblBacteria BAE77381 http://www.ensemblgenomes.org/id/BAE77381 EnsemblBacteria BAE77381 http://www.ensemblgenomes.org/id/BAE77381 EnsemblBacteria b3929 http://www.ensemblgenomes.org/id/b3929 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008428 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008428 GO_function GO:0060698 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060698 GO_process GO:0006401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006401 GO_process GO:0060702 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060702 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 Gene3D 3.50.30.40 http://www.cathdb.info/version/latest/superfamily/3.50.30.40 GeneID 948419 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948419 HAMAP MF_00471 http://hamap.expasy.org/unirule/MF_00471 HOGENOM HOG000252803 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000252803&db=HOGENOM6 InParanoid P0A8R0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8R0 IntAct P0A8R0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8R0* InterPro IPR005493 http://www.ebi.ac.uk/interpro/entry/IPR005493 InterPro IPR010203 http://www.ebi.ac.uk/interpro/entry/IPR010203 InterPro IPR014339 http://www.ebi.ac.uk/interpro/entry/IPR014339 KEGG_Gene ecj:JW3900 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3900 KEGG_Gene eco:b3929 http://www.genome.jp/dbget-bin/www_bget?eco:b3929 KEGG_Orthology KO:K02553 http://www.genome.jp/dbget-bin/www_bget?KO:K02553 OMA EDNTLVR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EDNTLVR PDB 1Q5X http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q5X PDB 2YJT http://www.ebi.ac.uk/pdbe-srv/view/entry/2YJT PDB 2YJV http://www.ebi.ac.uk/pdbe-srv/view/entry/2YJV PDBsum 1Q5X http://www.ebi.ac.uk/pdbsum/1Q5X PDBsum 2YJT http://www.ebi.ac.uk/pdbsum/2YJT PDBsum 2YJV http://www.ebi.ac.uk/pdbsum/2YJV PSORT swissprot:RRAA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RRAA_ECOLI PSORT-B swissprot:RRAA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RRAA_ECOLI PSORT2 swissprot:RRAA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RRAA_ECOLI Pfam PF03737 http://pfam.xfam.org/family/PF03737 Phobius swissprot:RRAA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RRAA_ECOLI PhylomeDB P0A8R0 http://phylomedb.org/?seqid=P0A8R0 ProteinModelPortal P0A8R0 http://www.proteinmodelportal.org/query/uniprot/P0A8R0 PubMed 13678585 http://www.ncbi.nlm.nih.gov/pubmed/13678585 PubMed 14499605 http://www.ncbi.nlm.nih.gov/pubmed/14499605 PubMed 16621818 http://www.ncbi.nlm.nih.gov/pubmed/16621818 PubMed 16725107 http://www.ncbi.nlm.nih.gov/pubmed/16725107 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16771842 http://www.ncbi.nlm.nih.gov/pubmed/16771842 PubMed 18510556 http://www.ncbi.nlm.nih.gov/pubmed/18510556 PubMed 20106955 http://www.ncbi.nlm.nih.gov/pubmed/20106955 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418364 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418364 RefSeq WP_000872908 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000872908 SMR P0A8R0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8R0 STRING 511145.b3929 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3929&targetmode=cogs STRING COG0684 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0684&targetmode=cogs SUPFAM SSF89562 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF89562 TIGRFAMs TIGR01935 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01935 TIGRFAMs TIGR02998 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02998 UniProtKB RRAA_ECOLI http://www.uniprot.org/uniprot/RRAA_ECOLI UniProtKB-AC P0A8R0 http://www.uniprot.org/uniprot/P0A8R0 charge swissprot:RRAA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RRAA_ECOLI eggNOG COG0684 http://eggnogapi.embl.de/nog_data/html/tree/COG0684 eggNOG ENOG4108YYX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108YYX epestfind swissprot:RRAA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RRAA_ECOLI garnier swissprot:RRAA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RRAA_ECOLI helixturnhelix swissprot:RRAA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RRAA_ECOLI hmoment swissprot:RRAA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RRAA_ECOLI iep swissprot:RRAA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RRAA_ECOLI inforesidue swissprot:RRAA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RRAA_ECOLI octanol swissprot:RRAA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RRAA_ECOLI pepcoil swissprot:RRAA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RRAA_ECOLI pepdigest swissprot:RRAA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RRAA_ECOLI pepinfo swissprot:RRAA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RRAA_ECOLI pepnet swissprot:RRAA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RRAA_ECOLI pepstats swissprot:RRAA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RRAA_ECOLI pepwheel swissprot:RRAA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RRAA_ECOLI pepwindow swissprot:RRAA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RRAA_ECOLI sigcleave swissprot:RRAA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RRAA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259111 169 # EcoGene EG11599 marB # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0008150 biological_process # InterPro IPR025732 MarB # Organism MARB_ECOLI Escherichia coli (strain K12) # PATRIC 32118362 VBIEscCol129921_1601 # PIR C47072 C47072 # Pfam PF13999 MarB # ProDom PD027692 PD027692 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MARB_ECOLI Multiple antibiotic resistance protein MarB # RefSeq NP_416049 NC_000913.3 # RefSeq WP_000803657 NZ_LN832404.1 # eggNOG ENOG4106DNR Bacteria # eggNOG ENOG410Y64J LUCA BLAST swissprot:MARB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MARB_ECOLI BioCyc ECOL316407:JW1525-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1525-MONOMER BioCyc EcoCyc:EG11599-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11599-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L06966 http://www.ebi.ac.uk/ena/data/view/L06966 EMBL M96235 http://www.ebi.ac.uk/ena/data/view/M96235 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1556 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1556 EcoGene EG11599 http://www.ecogene.org/geneInfo.php?eg_id=EG11599 EnsemblBacteria AAC74605 http://www.ensemblgenomes.org/id/AAC74605 EnsemblBacteria AAC74605 http://www.ensemblgenomes.org/id/AAC74605 EnsemblBacteria BAA15222 http://www.ensemblgenomes.org/id/BAA15222 EnsemblBacteria BAA15222 http://www.ensemblgenomes.org/id/BAA15222 EnsemblBacteria BAA15222 http://www.ensemblgenomes.org/id/BAA15222 EnsemblBacteria b1532 http://www.ensemblgenomes.org/id/b1532 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 946184 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946184 HOGENOM HOG000267916 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267916&db=HOGENOM6 InterPro IPR025732 http://www.ebi.ac.uk/interpro/entry/IPR025732 KEGG_Gene ecj:JW1525 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1525 KEGG_Gene eco:b1532 http://www.genome.jp/dbget-bin/www_bget?eco:b1532 KEGG_Orthology KO:K13630 http://www.genome.jp/dbget-bin/www_bget?KO:K13630 OMA HMGAGSD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HMGAGSD PSORT swissprot:MARB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MARB_ECOLI PSORT-B swissprot:MARB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MARB_ECOLI PSORT2 swissprot:MARB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MARB_ECOLI Pfam PF13999 http://pfam.xfam.org/family/PF13999 Phobius swissprot:MARB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MARB_ECOLI ProteinModelPortal P31121 http://www.proteinmodelportal.org/query/uniprot/P31121 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8383113 http://www.ncbi.nlm.nih.gov/pubmed/8383113 PubMed 8491710 http://www.ncbi.nlm.nih.gov/pubmed/8491710 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416049 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416049 RefSeq WP_000803657 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000803657 STRING 511145.b1532 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1532&targetmode=cogs UniProtKB MARB_ECOLI http://www.uniprot.org/uniprot/MARB_ECOLI UniProtKB-AC P31121 http://www.uniprot.org/uniprot/P31121 charge swissprot:MARB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MARB_ECOLI eggNOG ENOG4106DNR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106DNR eggNOG ENOG410Y64J http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y64J epestfind swissprot:MARB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MARB_ECOLI garnier swissprot:MARB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MARB_ECOLI helixturnhelix swissprot:MARB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MARB_ECOLI hmoment swissprot:MARB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MARB_ECOLI iep swissprot:MARB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MARB_ECOLI inforesidue swissprot:MARB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MARB_ECOLI octanol swissprot:MARB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MARB_ECOLI pepcoil swissprot:MARB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MARB_ECOLI pepdigest swissprot:MARB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MARB_ECOLI pepinfo swissprot:MARB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MARB_ECOLI pepnet swissprot:MARB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MARB_ECOLI pepstats swissprot:MARB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MARB_ECOLI pepwheel swissprot:MARB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MARB_ECOLI pepwindow swissprot:MARB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MARB_ECOLI sigcleave swissprot:MARB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MARB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260395 6 # COFACTOR C56H_ECOLI Name=heme b; Xref=ChEBI CHEBI 60344; Evidence={ECO 0000250}; Note=Binds 2 heme B (iron-protoporphyrin IX) groups per molecule. {ECO 0000250}; # EcoGene EG14050 yodB # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0009055 electron carrier activity; IEA:InterPro. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0022904 respiratory electron transport chain; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # InterPro IPR011577 Cyt_b561_bac/Ni-Hgenase # InterPro IPR016174 Di-haem_cyt_TM # Organism C56H_ECOLI Escherichia coli (strain K12) # PATRIC 32119279 VBIEscCol129921_2054 # PIR B64962 B64962 # Pfam PF01292 Ni_hydr_CYTB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName C56H_ECOLI Cytochrome b561 homolog 1 # RefSeq NP_416483 NC_000913.3 # RefSeq WP_001079074 NZ_LN832404.1 # SIMILARITY Belongs to the cytochrome b561 family. {ECO 0000305}. # SUBCELLULAR LOCATION C56H_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF81342 SSF81342 # eggNOG COG3038 LUCA # eggNOG ENOG4108VKM Bacteria BLAST swissprot:C56H_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:C56H_ECOLI BioCyc ECOL316407:JW5323-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5323-MONOMER BioCyc EcoCyc:G7062-MONOMER http://biocyc.org/getid?id=EcoCyc:G7062-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3803 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3803 EcoGene EG14050 http://www.ecogene.org/geneInfo.php?eg_id=EG14050 EnsemblBacteria AAC75040 http://www.ensemblgenomes.org/id/AAC75040 EnsemblBacteria AAC75040 http://www.ensemblgenomes.org/id/AAC75040 EnsemblBacteria BAA15798 http://www.ensemblgenomes.org/id/BAA15798 EnsemblBacteria BAA15798 http://www.ensemblgenomes.org/id/BAA15798 EnsemblBacteria BAA15798 http://www.ensemblgenomes.org/id/BAA15798 EnsemblBacteria b1974 http://www.ensemblgenomes.org/id/b1974 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0022904 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022904 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GeneID 946491 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946491 HOGENOM HOG000110384 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000110384&db=HOGENOM6 InParanoid P76345 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76345 InterPro IPR011577 http://www.ebi.ac.uk/interpro/entry/IPR011577 InterPro IPR016174 http://www.ebi.ac.uk/interpro/entry/IPR016174 KEGG_Gene ecj:JW5323 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5323 KEGG_Gene eco:b1974 http://www.genome.jp/dbget-bin/www_bget?eco:b1974 OMA SVERNLM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SVERNLM PSORT swissprot:C56H_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:C56H_ECOLI PSORT-B swissprot:C56H_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:C56H_ECOLI PSORT2 swissprot:C56H_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:C56H_ECOLI Pfam PF01292 http://pfam.xfam.org/family/PF01292 Phobius swissprot:C56H_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:C56H_ECOLI PhylomeDB P76345 http://phylomedb.org/?seqid=P76345 ProteinModelPortal P76345 http://www.proteinmodelportal.org/query/uniprot/P76345 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416483 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416483 RefSeq WP_001079074 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001079074 STRING 511145.b1974 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1974&targetmode=cogs SUPFAM SSF81342 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81342 UniProtKB C56H_ECOLI http://www.uniprot.org/uniprot/C56H_ECOLI UniProtKB-AC P76345 http://www.uniprot.org/uniprot/P76345 charge swissprot:C56H_ECOLI http://rest.g-language.org/emboss/charge/swissprot:C56H_ECOLI eggNOG COG3038 http://eggnogapi.embl.de/nog_data/html/tree/COG3038 eggNOG ENOG4108VKM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108VKM epestfind swissprot:C56H_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:C56H_ECOLI garnier swissprot:C56H_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:C56H_ECOLI helixturnhelix swissprot:C56H_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:C56H_ECOLI hmoment swissprot:C56H_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:C56H_ECOLI iep swissprot:C56H_ECOLI http://rest.g-language.org/emboss/iep/swissprot:C56H_ECOLI inforesidue swissprot:C56H_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:C56H_ECOLI octanol swissprot:C56H_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:C56H_ECOLI pepcoil swissprot:C56H_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:C56H_ECOLI pepdigest swissprot:C56H_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:C56H_ECOLI pepinfo swissprot:C56H_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:C56H_ECOLI pepnet swissprot:C56H_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:C56H_ECOLI pepstats swissprot:C56H_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:C56H_ECOLI pepwheel swissprot:C56H_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:C56H_ECOLI pepwindow swissprot:C56H_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:C56H_ECOLI sigcleave swissprot:C56H_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:C56H_ECOLI ## Database ID URL or Descriptions # AltName Z ring-associated protein ZapE {ECO:0000255|HAMAP-Rule MF_01919} # BioGrid 4261913 10 # DISRUPTION PHENOTYPE Mutants have no growth defect in aerobic conditions. However, inactivation leads to a stress-dependent elongated phenotype (in anaerobiosis or at temperatures over 37 degrees Celsius). {ECO:0000269|PubMed 24595368}. # EcoGene EG12819 zapE # FUNCTION ZAPE_ECOLI Reduces the stability of FtsZ polymers in the presence of ATP. Required for cell division under low-oxygen conditions. Hydrolyzes ATP but not GTP. {ECO 0000255|HAMAP-Rule MF_01919, ECO 0000269|PubMed 24595368}. # GO_component GO:0005737 cytoplasm; IDA:EcoCyc. # GO_component GO:0032153 cell division site; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0016887 ATPase activity; IDA:EcoCyc. # GO_process GO:0007049 cell cycle; IEA:UniProtKB-KW. # GO_process GO:0051301 cell division; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0007049 cell cycle # GOslim_process GO:0051301 cell division # Gene3D 3.40.50.300 -; 1. # HAMAP MF_01919 ZapE # InterPro IPR005654 ATPase_AFG1-like # InterPro IPR027417 P-loop_NTPase # InterPro IPR030870 ZapE # MISCELLANEOUS ZapE abundance has to be tightly regulated to allow cell division. Loss or overexpression of ZapE alters Z-ring stability and leads to bacterial filamentation (PubMed:24595368). {ECO 0000305|PubMed:24595368}. # Organism ZAPE_ECOLI Escherichia coli (strain K12) # PANTHER PTHR12169 PTHR12169 # PATRIC 32121890 VBIEscCol129921_3329 # PIR B65115 B65115 # Pfam PF03969 AFG1_ATPase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Cell division protein ZapE {ECO:0000255|HAMAP-Rule MF_01919} # RefSeq NP_417699 NC_000913.3 # RefSeq WP_001192332 NZ_LN832404.1 # SIMILARITY Belongs to the AFG1 ATPase family. ZapE subfamily. {ECO:0000255|HAMAP-Rule MF_01919}. # SUBCELLULAR LOCATION ZAPE_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_01919, ECO 0000269|PubMed 24595368}. Note=Localizes to the constricting Z-ring during late stages of the cell division process. # SUBUNIT ZAPE_ECOLI Interacts with FtsZ. {ECO 0000255|HAMAP-Rule MF_01919, ECO 0000269|PubMed 24595368}. # SUPFAM SSF52540 SSF52540 # eggNOG COG1485 LUCA # eggNOG ENOG4105D6Z Bacteria BLAST swissprot:ZAPE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ZAPE_ECOLI BioCyc ECOL316407:JW3201-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3201-MONOMER BioCyc EcoCyc:G7680-MONOMER http://biocyc.org/getid?id=EcoCyc:G7680-MONOMER COG COG1485 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1485 DIP DIP-48198N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48198N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/mBio.00022-14 http://dx.doi.org/10.1128/mBio.00022-14 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2670 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2670 EcoGene EG12819 http://www.ecogene.org/geneInfo.php?eg_id=EG12819 EnsemblBacteria AAC76264 http://www.ensemblgenomes.org/id/AAC76264 EnsemblBacteria AAC76264 http://www.ensemblgenomes.org/id/AAC76264 EnsemblBacteria BAE77275 http://www.ensemblgenomes.org/id/BAE77275 EnsemblBacteria BAE77275 http://www.ensemblgenomes.org/id/BAE77275 EnsemblBacteria BAE77275 http://www.ensemblgenomes.org/id/BAE77275 EnsemblBacteria b3232 http://www.ensemblgenomes.org/id/b3232 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0032153 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032153 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947821 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947821 HAMAP MF_01919 http://hamap.expasy.org/unirule/MF_01919 HOGENOM HOG000259599 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000259599&db=HOGENOM6 InParanoid P64612 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P64612 IntAct P64612 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P64612* InterPro IPR005654 http://www.ebi.ac.uk/interpro/entry/IPR005654 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR030870 http://www.ebi.ac.uk/interpro/entry/IPR030870 KEGG_Gene ecj:JW3201 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3201 KEGG_Gene eco:b3232 http://www.genome.jp/dbget-bin/www_bget?eco:b3232 KEGG_Orthology KO:K06916 http://www.genome.jp/dbget-bin/www_bget?KO:K06916 OMA MRTHFHR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MRTHFHR PANTHER PTHR12169 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12169 PSORT swissprot:ZAPE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ZAPE_ECOLI PSORT-B swissprot:ZAPE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ZAPE_ECOLI PSORT2 swissprot:ZAPE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ZAPE_ECOLI Pfam PF03969 http://pfam.xfam.org/family/PF03969 Phobius swissprot:ZAPE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ZAPE_ECOLI PhylomeDB P64612 http://phylomedb.org/?seqid=P64612 ProteinModelPortal P64612 http://www.proteinmodelportal.org/query/uniprot/P64612 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 24595368 http://www.ncbi.nlm.nih.gov/pubmed/24595368 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417699 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417699 RefSeq WP_001192332 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001192332 SMR P64612 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P64612 STRING 511145.b3232 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3232&targetmode=cogs STRING COG1485 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1485&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB ZAPE_ECOLI http://www.uniprot.org/uniprot/ZAPE_ECOLI UniProtKB-AC P64612 http://www.uniprot.org/uniprot/P64612 charge swissprot:ZAPE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ZAPE_ECOLI eggNOG COG1485 http://eggnogapi.embl.de/nog_data/html/tree/COG1485 eggNOG ENOG4105D6Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D6Z epestfind swissprot:ZAPE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ZAPE_ECOLI garnier swissprot:ZAPE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ZAPE_ECOLI helixturnhelix swissprot:ZAPE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ZAPE_ECOLI hmoment swissprot:ZAPE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ZAPE_ECOLI iep swissprot:ZAPE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ZAPE_ECOLI inforesidue swissprot:ZAPE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ZAPE_ECOLI octanol swissprot:ZAPE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ZAPE_ECOLI pepcoil swissprot:ZAPE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ZAPE_ECOLI pepdigest swissprot:ZAPE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ZAPE_ECOLI pepinfo swissprot:ZAPE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ZAPE_ECOLI pepnet swissprot:ZAPE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ZAPE_ECOLI pepstats swissprot:ZAPE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ZAPE_ECOLI pepwheel swissprot:ZAPE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ZAPE_ECOLI pepwindow swissprot:ZAPE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ZAPE_ECOLI sigcleave swissprot:ZAPE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ZAPE_ECOLI ## Database ID URL or Descriptions # AltName 5'-phosphoribosylglycinamide transformylase 2 {ECO:0000255|HAMAP-Rule MF_01643} # AltName Formate-dependent GAR transformylase {ECO:0000255|HAMAP-Rule MF_01643} # AltName GAR transformylase 2 {ECO:0000255|HAMAP-Rule MF_01643} # BIOPHYSICOCHEMICAL PROPERTIES PURT_ECOLI Kinetic parameters KM=10.1 uM for GAR (at pH 8) {ECO 0000269|PubMed 8117714}; KM=319 uM for formate (at pH 8) {ECO 0000269|PubMed 8117714}; Note=Kcat is 37.6 sec(-1) for transferase activity (at pH 8). {ECO 0000269|PubMed 8117714}; # CATALYTIC ACTIVITY Formate + ATP + 5'-phospho-ribosylglycinamide = 5'-phosphoribosyl-N-formylglycinamide + ADP + diphosphate. {ECO:0000269|PubMed 8117714}. # EcoGene EG11809 purT # FUNCTION PURT_ECOLI Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR; the second, a side reaction, is the production of acetyl phosphate and ADP from acetate and ATP. {ECO 0000269|PubMed 8117714}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IEA:InterPro. # GO_function GO:0004638 phosphoribosylaminoimidazole carboxylase activity; IBA:GO_Central. # GO_function GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity; IBA:GO_Central. # GO_function GO:0004644 phosphoribosylglycinamide formyltransferase activity; IEA:InterPro. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008776 acetate kinase activity; IDA:EcoCyc. # GO_function GO:0043815 phosphoribosylglycinamide formyltransferase 2 activity; IEA:UniProtKB-HAMAP. # GO_process GO:0006189 'de novo' IMP biosynthetic process; IBA:GO_Central. # GO_process GO:0046084 adenine biosynthetic process; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.30.1490.20 -; 1. # Gene3D 3.30.470.20 -; 1. # Gene3D 3.40.50.20 -; 1. # HAMAP MF_01643 PurT # INTERACTION PURT_ECOLI P22939 ispA; NbExp=3; IntAct=EBI-553029, EBI-553011; # IntAct P33221 7 # InterPro IPR003135 ATP-grasp_carboxylate-amine # InterPro IPR005862 PurT # InterPro IPR011054 Rudment_hybrid_motif # InterPro IPR011761 ATP-grasp # InterPro IPR013815 ATP_grasp_subdomain_1 # InterPro IPR013816 ATP_grasp_subdomain_2 # InterPro IPR016185 PreATP-grasp_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00670 One carbon pool by folate # Organism PURT_ECOLI Escherichia coli (strain K12) # PATHWAY Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5- phospho-D-ribosyl)glycinamide (formate route): step 1/1. {ECO 0000255|HAMAP-Rule:MF_01643}. # PATRIC 32119019 VBIEscCol129921_1927 # PDB 1EYZ X-ray; 1.75 A; A/B=1-392 # PDB 1EZ1 X-ray; 1.75 A; A/B=1-392 # PDB 1KJ8 X-ray; 1.60 A; A/B=2-392 # PDB 1KJ9 X-ray; 1.60 A; A/B=2-392 # PDB 1KJI X-ray; 1.60 A; A/B=2-392 # PDB 1KJJ X-ray; 1.75 A; A/B=2-392 # PDB 1KJQ X-ray; 1.05 A; A/B=2-392 # PDB 1NFE Model; -; A=1-392 # PIR A54227 A54227 # PROSITE PS50975 ATP_GRASP # Pfam PF02222 ATP-grasp # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Phosphoribosylglycinamide formyltransferase 2 {ECO:0000255|HAMAP-Rule MF_01643} # RefSeq NP_416363 NC_000913.3 # RefSeq WP_000173484 NZ_LN832404.1 # SIMILARITY Belongs to the PurK/PurT family. {ECO:0000255|HAMAP- Rule MF_01643}. # SIMILARITY Contains 1 ATP-grasp domain. {ECO:0000255|HAMAP- Rule MF_01643}. # SUBUNIT PURT_ECOLI Homodimer. {ECO 0000269|PubMed 10913290, ECO 0000269|PubMed 11953435, ECO 0000269|PubMed 8117714}. # SUPFAM SSF51246 SSF51246 # SUPFAM SSF52440 SSF52440 # TIGRFAMs TIGR01142 purT # UniPathway UPA00074 UER00127 # eggNOG COG0027 LUCA # eggNOG ENOG4108HH9 Bacteria BLAST swissprot:PURT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PURT_ECOLI BioCyc ECOL316407:JW1838-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1838-MONOMER BioCyc EcoCyc:GARTRANSFORMYL2-MONOMER http://biocyc.org/getid?id=EcoCyc:GARTRANSFORMYL2-MONOMER BioCyc MetaCyc:GARTRANSFORMYL2-MONOMER http://biocyc.org/getid?id=MetaCyc:GARTRANSFORMYL2-MONOMER COG COG0027 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0027 DIP DIP-10618N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10618N DOI 10.1021/bi000926j http://dx.doi.org/10.1021/bi000926j DOI 10.1021/bi00175a023 http://dx.doi.org/10.1021/bi00175a023 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M202251200 http://dx.doi.org/10.1074/jbc.M202251200 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.2.- {ECO:0000269|PubMed:8117714} http://www.genome.jp/dbget-bin/www_bget?EC:2.1.2.- {ECO:0000269|PubMed:8117714} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L20897 http://www.ebi.ac.uk/ena/data/view/L20897 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.1.2.- {ECO:0000269|PubMed:8117714} http://enzyme.expasy.org/EC/2.1.2.- {ECO:0000269|PubMed:8117714} EchoBASE EB1757 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1757 EcoGene EG11809 http://www.ecogene.org/geneInfo.php?eg_id=EG11809 EnsemblBacteria AAC74919 http://www.ensemblgenomes.org/id/AAC74919 EnsemblBacteria AAC74919 http://www.ensemblgenomes.org/id/AAC74919 EnsemblBacteria BAA15657 http://www.ensemblgenomes.org/id/BAA15657 EnsemblBacteria BAA15657 http://www.ensemblgenomes.org/id/BAA15657 EnsemblBacteria BAA15657 http://www.ensemblgenomes.org/id/BAA15657 EnsemblBacteria b1849 http://www.ensemblgenomes.org/id/b1849 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0004638 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004638 GO_function GO:0004639 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004639 GO_function GO:0004644 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004644 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008776 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008776 GO_function GO:0043815 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043815 GO_process GO:0006189 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006189 GO_process GO:0046084 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046084 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.30.1490.20 http://www.cathdb.info/version/latest/superfamily/3.30.1490.20 Gene3D 3.30.470.20 http://www.cathdb.info/version/latest/superfamily/3.30.470.20 Gene3D 3.40.50.20 http://www.cathdb.info/version/latest/superfamily/3.40.50.20 GeneID 946368 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946368 HAMAP MF_01643 http://hamap.expasy.org/unirule/MF_01643 HOGENOM HOG000072820 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000072820&db=HOGENOM6 InParanoid P33221 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33221 IntAct P33221 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33221* IntEnz 2.1.2.- {ECO:0000269|PubMed:8117714} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.2.- {ECO:0000269|PubMed:8117714} InterPro IPR003135 http://www.ebi.ac.uk/interpro/entry/IPR003135 InterPro IPR005862 http://www.ebi.ac.uk/interpro/entry/IPR005862 InterPro IPR011054 http://www.ebi.ac.uk/interpro/entry/IPR011054 InterPro IPR011761 http://www.ebi.ac.uk/interpro/entry/IPR011761 InterPro IPR013815 http://www.ebi.ac.uk/interpro/entry/IPR013815 InterPro IPR013816 http://www.ebi.ac.uk/interpro/entry/IPR013816 InterPro IPR016185 http://www.ebi.ac.uk/interpro/entry/IPR016185 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1838 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1838 KEGG_Gene eco:b1849 http://www.genome.jp/dbget-bin/www_bget?eco:b1849 KEGG_Orthology KO:K08289 http://www.genome.jp/dbget-bin/www_bget?KO:K08289 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00670 http://www.genome.jp/kegg-bin/show_pathway?ko00670 KEGG_Reaction rn:R04325 http://www.genome.jp/dbget-bin/www_bget?rn:R04325 KEGG_Reaction rn:R04326 http://www.genome.jp/dbget-bin/www_bget?rn:R04326 MINT MINT-1306001 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1306001 OMA IFGVEFF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IFGVEFF PDB 1EYZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1EYZ PDB 1EZ1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1EZ1 PDB 1KJ8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1KJ8 PDB 1KJ9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1KJ9 PDB 1KJI http://www.ebi.ac.uk/pdbe-srv/view/entry/1KJI PDB 1KJJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1KJJ PDB 1KJQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1KJQ PDB 1NFE http://www.ebi.ac.uk/pdbe-srv/view/entry/1NFE PDBsum 1EYZ http://www.ebi.ac.uk/pdbsum/1EYZ PDBsum 1EZ1 http://www.ebi.ac.uk/pdbsum/1EZ1 PDBsum 1KJ8 http://www.ebi.ac.uk/pdbsum/1KJ8 PDBsum 1KJ9 http://www.ebi.ac.uk/pdbsum/1KJ9 PDBsum 1KJI http://www.ebi.ac.uk/pdbsum/1KJI PDBsum 1KJJ http://www.ebi.ac.uk/pdbsum/1KJJ PDBsum 1KJQ http://www.ebi.ac.uk/pdbsum/1KJQ PDBsum 1NFE http://www.ebi.ac.uk/pdbsum/1NFE PROSITE PS50975 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50975 PSORT swissprot:PURT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PURT_ECOLI PSORT-B swissprot:PURT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PURT_ECOLI PSORT2 swissprot:PURT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PURT_ECOLI Pfam PF02222 http://pfam.xfam.org/family/PF02222 Phobius swissprot:PURT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PURT_ECOLI PhylomeDB P33221 http://phylomedb.org/?seqid=P33221 ProteinModelPortal P33221 http://www.proteinmodelportal.org/query/uniprot/P33221 PubMed 10913290 http://www.ncbi.nlm.nih.gov/pubmed/10913290 PubMed 11953435 http://www.ncbi.nlm.nih.gov/pubmed/11953435 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 8117714 http://www.ncbi.nlm.nih.gov/pubmed/8117714 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416363 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416363 RefSeq WP_000173484 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000173484 SMR P33221 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33221 STRING 511145.b1849 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1849&targetmode=cogs STRING COG0027 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0027&targetmode=cogs SUPFAM SSF51246 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51246 SUPFAM SSF52440 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52440 TIGRFAMs TIGR01142 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01142 UniProtKB PURT_ECOLI http://www.uniprot.org/uniprot/PURT_ECOLI UniProtKB-AC P33221 http://www.uniprot.org/uniprot/P33221 charge swissprot:PURT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PURT_ECOLI eggNOG COG0027 http://eggnogapi.embl.de/nog_data/html/tree/COG0027 eggNOG ENOG4108HH9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108HH9 epestfind swissprot:PURT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PURT_ECOLI garnier swissprot:PURT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PURT_ECOLI helixturnhelix swissprot:PURT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PURT_ECOLI hmoment swissprot:PURT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PURT_ECOLI iep swissprot:PURT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PURT_ECOLI inforesidue swissprot:PURT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PURT_ECOLI octanol swissprot:PURT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PURT_ECOLI pepcoil swissprot:PURT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PURT_ECOLI pepdigest swissprot:PURT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PURT_ECOLI pepinfo swissprot:PURT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PURT_ECOLI pepnet swissprot:PURT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PURT_ECOLI pepstats swissprot:PURT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PURT_ECOLI pepwheel swissprot:PURT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PURT_ECOLI pepwindow swissprot:PURT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PURT_ECOLI sigcleave swissprot:PURT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PURT_ECOLI ## Database ID URL or Descriptions # AltName DING_ECOLI DNA-damage-inducible protein G # BioGrid 4259964 118 # CATALYTIC ACTIVITY DING_ECOLI ATP + H(2)O = ADP + phosphate. # COFACTOR DING_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000269|PubMed 19074432}; Note=Binds 1 [4Fe-4S] cluster. {ECO 0000269|PubMed 19074432}; # DOMAIN DING_ECOLI 4Fe-4S iron-sulfur-binding is required for protein stability and helicase activity. The cluster is modified by nitric oxide, forming the DinG-bound dinitrosyl iron complex with the inactivation of helicase activity (PubMed 19074432). {ECO 0000269|PubMed 19074432}. # EcoGene EG11357 dinG # FUNCTION DING_ECOLI Probable helicase involved in DNA repair and perhaps also replication. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003678 DNA helicase activity; IDA:EcoliWiki. # GO_function GO:0004003 ATP-dependent DNA helicase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016887 ATPase activity; IDA:EcoliWiki. # GO_function GO:0033680 ATP-dependent DNA/RNA helicase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IDA:EcoCyc. # GO_process GO:0006281 DNA repair; IEA:UniProtKB-KW. # GO_process GO:0006310 DNA recombination; IEA:UniProtKB-KW. # GO_process GO:0009432 SOS response; IEP:EcoCyc. # GO_process GO:0032508 DNA duplex unwinding; IDA:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004386 helicase activity # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0051276 chromosome organization # Gene3D 3.40.50.300 -; 3. # INTERACTION DING_ECOLI P0AGE0 ssb; NbExp=2; IntAct=EBI-1114590, EBI-1118620; # IntAct P27296 22 # InterPro IPR006554 Helicase-like_DEXD_c2 # InterPro IPR006555 ATP-dep_Helicase_C # InterPro IPR010614 DEAD_2 # InterPro IPR011545 DEAD/DEAH_box_helicase_dom # InterPro IPR014001 Helicase_ATP-bd # InterPro IPR014013 Helic_SF1/SF2_ATP-bd_DinG/Rad3 # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # Organism DING_ECOLI Escherichia coli (strain K12) # PATRIC 32116801 VBIEscCol129921_0826 # PIR G64816 G64816 # PROSITE PS51193 HELICASE_ATP_BIND_2 # Pfam PF00270 DEAD # Pfam PF06733 DEAD_2 # Pfam PF13307 Helicase_C_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DING_ECOLI Probable ATP-dependent helicase DinG # RefSeq NP_415320 NC_000913.3 # RefSeq WP_001340191 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA23685.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the helicase family. DinG subfamily. {ECO 0000305}. # SIMILARITY Contains 1 helicase ATP-binding domain. {ECO:0000255|PROSITE-ProRule PRU00541}. # SMART SM00487 DEXDc # SMART SM00488 DEXDc2 # SMART SM00491 HELICc2 # SUPFAM SSF52540 SSF52540; 4 # eggNOG COG1199 LUCA # eggNOG ENOG4105DVT Bacteria BLAST swissprot:DING_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DING_ECOLI BioCyc ECOL316407:JW0784-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0784-MONOMER BioCyc EcoCyc:EG11357-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11357-MONOMER COG COG1199 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1199 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M807943200 http://dx.doi.org/10.1074/jbc.M807943200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/21.6.1497 http://dx.doi.org/10.1093/nar/21.6.1497 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1266/jjg.69.1 http://dx.doi.org/10.1266/jjg.69.1 EC_number EC:3.6.4.12 http://www.genome.jp/dbget-bin/www_bget?EC:3.6.4.12 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L02123 http://www.ebi.ac.uk/ena/data/view/L02123 EMBL M81935 http://www.ebi.ac.uk/ena/data/view/M81935 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.6.4.12 http://enzyme.expasy.org/EC/3.6.4.12 EchoBASE EB1332 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1332 EcoGene EG11357 http://www.ecogene.org/geneInfo.php?eg_id=EG11357 EnsemblBacteria AAC73886 http://www.ensemblgenomes.org/id/AAC73886 EnsemblBacteria AAC73886 http://www.ensemblgenomes.org/id/AAC73886 EnsemblBacteria BAA35465 http://www.ensemblgenomes.org/id/BAA35465 EnsemblBacteria BAA35465 http://www.ensemblgenomes.org/id/BAA35465 EnsemblBacteria BAA35465 http://www.ensemblgenomes.org/id/BAA35465 EnsemblBacteria b0799 http://www.ensemblgenomes.org/id/b0799 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003678 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003678 GO_function GO:0004003 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004003 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_function GO:0033680 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033680 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0006281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006281 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0009432 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009432 GO_process GO:0032508 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032508 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004386 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0051276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051276 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945431 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945431 HOGENOM HOG000242573 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000242573&db=HOGENOM6 InParanoid P27296 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P27296 IntAct P27296 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P27296* IntEnz 3.6.4.12 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.4.12 InterPro IPR006554 http://www.ebi.ac.uk/interpro/entry/IPR006554 InterPro IPR006555 http://www.ebi.ac.uk/interpro/entry/IPR006555 InterPro IPR010614 http://www.ebi.ac.uk/interpro/entry/IPR010614 InterPro IPR011545 http://www.ebi.ac.uk/interpro/entry/IPR011545 InterPro IPR014001 http://www.ebi.ac.uk/interpro/entry/IPR014001 InterPro IPR014013 http://www.ebi.ac.uk/interpro/entry/IPR014013 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW0784 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0784 KEGG_Gene eco:b0799 http://www.genome.jp/dbget-bin/www_bget?eco:b0799 KEGG_Orthology KO:K03722 http://www.genome.jp/dbget-bin/www_bget?KO:K03722 MINT MINT-8393557 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8393557 OMA CAGIRVC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CAGIRVC PROSITE PS51193 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51193 PSORT swissprot:DING_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DING_ECOLI PSORT-B swissprot:DING_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DING_ECOLI PSORT2 swissprot:DING_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DING_ECOLI Pfam PF00270 http://pfam.xfam.org/family/PF00270 Pfam PF06733 http://pfam.xfam.org/family/PF06733 Pfam PF13307 http://pfam.xfam.org/family/PF13307 Phobius swissprot:DING_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DING_ECOLI PhylomeDB P27296 http://phylomedb.org/?seqid=P27296 ProteinModelPortal P27296 http://www.proteinmodelportal.org/query/uniprot/P27296 PubMed 1629168 http://www.ncbi.nlm.nih.gov/pubmed/1629168 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19074432 http://www.ncbi.nlm.nih.gov/pubmed/19074432 PubMed 8037924 http://www.ncbi.nlm.nih.gov/pubmed/8037924 PubMed 8385320 http://www.ncbi.nlm.nih.gov/pubmed/8385320 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415320 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415320 RefSeq WP_001340191 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001340191 SMART SM00487 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00487 SMART SM00488 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00488 SMART SM00491 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00491 STRING 511145.b0799 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0799&targetmode=cogs STRING COG1199 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1199&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB DING_ECOLI http://www.uniprot.org/uniprot/DING_ECOLI UniProtKB-AC P27296 http://www.uniprot.org/uniprot/P27296 charge swissprot:DING_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DING_ECOLI eggNOG COG1199 http://eggnogapi.embl.de/nog_data/html/tree/COG1199 eggNOG ENOG4105DVT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DVT epestfind swissprot:DING_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DING_ECOLI garnier swissprot:DING_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DING_ECOLI helixturnhelix swissprot:DING_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DING_ECOLI hmoment swissprot:DING_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DING_ECOLI iep swissprot:DING_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DING_ECOLI inforesidue swissprot:DING_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DING_ECOLI octanol swissprot:DING_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DING_ECOLI pepcoil swissprot:DING_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DING_ECOLI pepdigest swissprot:DING_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DING_ECOLI pepinfo swissprot:DING_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DING_ECOLI pepnet swissprot:DING_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DING_ECOLI pepstats swissprot:DING_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DING_ECOLI pepwheel swissprot:DING_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DING_ECOLI pepwindow swissprot:DING_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DING_ECOLI sigcleave swissprot:DING_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DING_ECOLI ## Database ID URL or Descriptions # BioGrid 4261174 9 # EcoGene EG13482 ydjF # GO_component GO:0005622 intracellular; IEA:InterPro. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_component GO:0005622 intracellular # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # IntAct P77721 17 # InterPro IPR001034 DeoR_HTH # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR014036 DeoR_C # InterPro IPR018356 Tscrpt_reg_HTH_DeoR_CS # Organism YDJF_ECOLI Escherichia coli (strain K12) # PATRIC 32118851 VBIEscCol129921_1843 # PIR B64937 B64937 # PRINTS PR00037 HTHLACR # PROSITE PS00894 HTH_DEOR_1 # PROSITE PS51000 HTH_DEOR_2 # Pfam PF00455 DeoRC # Pfam PF08220 HTH_DeoR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDJF_ECOLI Uncharacterized HTH-type transcriptional regulator YdjF # RefSeq NP_416284 NC_000913.3 # RefSeq WP_000719096 NZ_LN832404.1 # SIMILARITY Contains 1 HTH deoR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00349}. # SMART SM00420 HTH_DEOR # SUPFAM SSF46785 SSF46785 # eggNOG COG1349 LUCA # eggNOG ENOG4105E98 Bacteria BLAST swissprot:YDJF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDJF_ECOLI BioCyc ECOL316407:JW1759-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1759-MONOMER BioCyc EcoCyc:G6957-MONOMER http://biocyc.org/getid?id=EcoCyc:G6957-MONOMER DIP DIP-11769N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11769N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3255 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3255 EcoGene EG13482 http://www.ecogene.org/geneInfo.php?eg_id=EG13482 EnsemblBacteria AAC74840 http://www.ensemblgenomes.org/id/AAC74840 EnsemblBacteria AAC74840 http://www.ensemblgenomes.org/id/AAC74840 EnsemblBacteria BAA15561 http://www.ensemblgenomes.org/id/BAA15561 EnsemblBacteria BAA15561 http://www.ensemblgenomes.org/id/BAA15561 EnsemblBacteria BAA15561 http://www.ensemblgenomes.org/id/BAA15561 EnsemblBacteria b1770 http://www.ensemblgenomes.org/id/b1770 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 946272 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946272 HOGENOM HOG000224683 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000224683&db=HOGENOM6 InParanoid P77721 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77721 IntAct P77721 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77721* InterPro IPR001034 http://www.ebi.ac.uk/interpro/entry/IPR001034 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR014036 http://www.ebi.ac.uk/interpro/entry/IPR014036 InterPro IPR018356 http://www.ebi.ac.uk/interpro/entry/IPR018356 KEGG_Gene ecj:JW1759 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1759 KEGG_Gene eco:b1770 http://www.genome.jp/dbget-bin/www_bget?eco:b1770 OMA AGSTTME http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AGSTTME PRINTS PR00037 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00037 PROSITE PS00894 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00894 PROSITE PS51000 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51000 PSORT swissprot:YDJF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDJF_ECOLI PSORT-B swissprot:YDJF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDJF_ECOLI PSORT2 swissprot:YDJF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDJF_ECOLI Pfam PF00455 http://pfam.xfam.org/family/PF00455 Pfam PF08220 http://pfam.xfam.org/family/PF08220 Phobius swissprot:YDJF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDJF_ECOLI PhylomeDB P77721 http://phylomedb.org/?seqid=P77721 ProteinModelPortal P77721 http://www.proteinmodelportal.org/query/uniprot/P77721 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416284 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416284 RefSeq WP_000719096 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000719096 SMART SM00420 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00420 STRING 511145.b1770 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1770&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB YDJF_ECOLI http://www.uniprot.org/uniprot/YDJF_ECOLI UniProtKB-AC P77721 http://www.uniprot.org/uniprot/P77721 charge swissprot:YDJF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDJF_ECOLI eggNOG COG1349 http://eggnogapi.embl.de/nog_data/html/tree/COG1349 eggNOG ENOG4105E98 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E98 epestfind swissprot:YDJF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDJF_ECOLI garnier swissprot:YDJF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDJF_ECOLI helixturnhelix swissprot:YDJF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDJF_ECOLI hmoment swissprot:YDJF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDJF_ECOLI iep swissprot:YDJF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDJF_ECOLI inforesidue swissprot:YDJF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDJF_ECOLI octanol swissprot:YDJF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDJF_ECOLI pepcoil swissprot:YDJF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDJF_ECOLI pepdigest swissprot:YDJF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDJF_ECOLI pepinfo swissprot:YDJF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDJF_ECOLI pepnet swissprot:YDJF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDJF_ECOLI pepstats swissprot:YDJF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDJF_ECOLI pepwheel swissprot:YDJF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDJF_ECOLI pepwindow swissprot:YDJF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDJF_ECOLI sigcleave swissprot:YDJF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDJF_ECOLI ## Database ID URL or Descriptions # AltName REPE1_ECOLI Protein F4 # FUNCTION REPE1_ECOLI Replication initiator in the monomeric form, and autogenous repressor in the dimeric form. # GO_component GO:0005727 extrachromosomal circular DNA; IEA:InterPro. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003887 DNA-directed DNA polymerase activity; IEA:InterPro. # GO_process GO:0006270 DNA replication initiation; IEA:InterPro. # GO_process GO:0006276 plasmid maintenance; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0008150 biological_process # Gene3D 1.10.10.10 -; 2. # InterPro IPR000525 Initiator_Rep_prot # InterPro IPR011991 WHTH_DNA-bd_dom # Organism REPE1_ECOLI Escherichia coli (strain K12) # PDB 1REP X-ray; 2.60 A; C=1-251 # PDB 2Z9O X-ray; 3.14 A; A/B=2-251 # PIR A91487 QQECF # Pfam PF01051 Rep_3 # RecName REPE1_ECOLI Replication initiation protein # RefSeq NP_061424 NC_002483.1 # RefSeq WP_000852146 NZ_CP014273.1 # SIMILARITY Belongs to the initiator RepB protein family. {ECO 0000305}. # SUBUNIT Monomer and homodimer. {ECO:0000269|PubMed 10469640}. # SUPFAM SSF46785 SSF46785; 2 BLAST swissprot:REPE1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:REPE1_ECOLI DIP DIP-27645N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-27645N DOI 10.1007/BF00330529 http://dx.doi.org/10.1007/BF00330529 DOI 10.1016/0022-2836(86)90459-6 http://dx.doi.org/10.1016/0022-2836(86)90459-6 DOI 10.1016/0092-8674(81)90095-7 http://dx.doi.org/10.1016/0092-8674(81)90095-7 DOI 10.1016/0378-1119(81)90135-9 http://dx.doi.org/10.1016/0378-1119(81)90135-9 DOI 10.1093/emboj/18.17.4597 http://dx.doi.org/10.1093/emboj/18.17.4597 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL J01724 http://www.ebi.ac.uk/ena/data/view/J01724 EMBL M12987 http://www.ebi.ac.uk/ena/data/view/M12987 EMBL X03410 http://www.ebi.ac.uk/ena/data/view/X03410 EMBL X04619 http://www.ebi.ac.uk/ena/data/view/X04619 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005727 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005727 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003887 GO_process GO:0006270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006270 GO_process GO:0006276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006276 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 1263547 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263547 InterPro IPR000525 http://www.ebi.ac.uk/interpro/entry/IPR000525 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 OMA ETHDSEN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ETHDSEN PDB 1REP http://www.ebi.ac.uk/pdbe-srv/view/entry/1REP PDB 2Z9O http://www.ebi.ac.uk/pdbe-srv/view/entry/2Z9O PDBsum 1REP http://www.ebi.ac.uk/pdbsum/1REP PDBsum 2Z9O http://www.ebi.ac.uk/pdbsum/2Z9O PSORT swissprot:REPE1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:REPE1_ECOLI PSORT-B swissprot:REPE1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:REPE1_ECOLI PSORT2 swissprot:REPE1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:REPE1_ECOLI Pfam PF01051 http://pfam.xfam.org/family/PF01051 Phobius swissprot:REPE1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:REPE1_ECOLI PhylomeDB P03856 http://phylomedb.org/?seqid=P03856 ProteinModelPortal P03856 http://www.proteinmodelportal.org/query/uniprot/P03856 PubMed 10469640 http://www.ncbi.nlm.nih.gov/pubmed/10469640 PubMed 3007930 http://www.ncbi.nlm.nih.gov/pubmed/3007930 PubMed 3029390 http://www.ncbi.nlm.nih.gov/pubmed/3029390 PubMed 7018695 http://www.ncbi.nlm.nih.gov/pubmed/7018695 PubMed 7028572 http://www.ncbi.nlm.nih.gov/pubmed/7028572 RefSeq NP_061424 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061424 RefSeq WP_000852146 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000852146 SMR P03856 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P03856 SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB REPE1_ECOLI http://www.uniprot.org/uniprot/REPE1_ECOLI UniProtKB-AC P03856 http://www.uniprot.org/uniprot/P03856 charge swissprot:REPE1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:REPE1_ECOLI epestfind swissprot:REPE1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:REPE1_ECOLI garnier swissprot:REPE1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:REPE1_ECOLI helixturnhelix swissprot:REPE1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:REPE1_ECOLI hmoment swissprot:REPE1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:REPE1_ECOLI iep swissprot:REPE1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:REPE1_ECOLI inforesidue swissprot:REPE1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:REPE1_ECOLI octanol swissprot:REPE1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:REPE1_ECOLI pepcoil swissprot:REPE1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:REPE1_ECOLI pepdigest swissprot:REPE1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:REPE1_ECOLI pepinfo swissprot:REPE1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:REPE1_ECOLI pepnet swissprot:REPE1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:REPE1_ECOLI pepstats swissprot:REPE1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:REPE1_ECOLI pepwheel swissprot:REPE1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:REPE1_ECOLI pepwindow swissprot:REPE1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:REPE1_ECOLI sigcleave swissprot:REPE1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:REPE1_ECOLI ## Database ID URL or Descriptions # BioGrid 4260186 178 # EcoGene EG13756 insQ # FUNCTION INSQ_ECOLI Required for the transposition of the insertion element. {ECO 0000305}. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006310 DNA recombination; IEA:UniProtKB-KW. # GO_process GO:0032196 transposition; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # InterPro IPR001959 Transposase_2 # InterPro IPR010095 Transposase_IS605_OrfB_C # InterPro IPR021027 Transposase_put_HTH # Organism INSQ_ECOLI Escherichia coli (strain K12) # PATRIC 32118154 VBIEscCol129921_1497 # PIR C64895 C64895 # Pfam PF01385 OrfB_IS605 # Pfam PF07282 OrfB_Zn_ribbon # Pfam PF12323 HTH_OrfB_IS605 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSQ_ECOLI Putative transposase InsQ for insertion sequence element IS609 # RefSeq NP_415949 NC_000913.3 # RefSeq WP_001251043 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA15060.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY In the C-terminal section; belongs to the transposase 35 family. {ECO 0000305}. # SIMILARITY In the N-terminal section; belongs to the transposase 2 family. {ECO 0000305}. # TIGRFAMs TIGR01766 tspaseT_teng_C # eggNOG COG0675 LUCA # eggNOG ENOG4105D7V Bacteria BLAST swissprot:INSQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSQ_ECOLI BioCyc ECOL316407:JW5228-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5228-MONOMER BioCyc EcoCyc:G6743-MONOMER http://biocyc.org/getid?id=EcoCyc:G6743-MONOMER COG COG0675 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0675 DIP DIP-48268N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48268N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3519 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3519 EcoGene EG13756 http://www.ecogene.org/geneInfo.php?eg_id=EG13756 EnsemblBacteria AAC74514 http://www.ensemblgenomes.org/id/AAC74514 EnsemblBacteria AAC74514 http://www.ensemblgenomes.org/id/AAC74514 EnsemblBacteria BAA15060 http://www.ensemblgenomes.org/id/BAA15060 EnsemblBacteria BAA15060 http://www.ensemblgenomes.org/id/BAA15060 EnsemblBacteria BAA15060 http://www.ensemblgenomes.org/id/BAA15060 EnsemblBacteria b1432 http://www.ensemblgenomes.org/id/b1432 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GeneID 944942 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944942 HOGENOM HOG000125070 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125070&db=HOGENOM6 InParanoid P76102 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76102 IntAct P76102 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76102* InterPro IPR001959 http://www.ebi.ac.uk/interpro/entry/IPR001959 InterPro IPR010095 http://www.ebi.ac.uk/interpro/entry/IPR010095 InterPro IPR021027 http://www.ebi.ac.uk/interpro/entry/IPR021027 KEGG_Gene ecj:JW5228 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5228 KEGG_Gene eco:b1432 http://www.genome.jp/dbget-bin/www_bget?eco:b1432 KEGG_Orthology KO:K07496 http://www.genome.jp/dbget-bin/www_bget?KO:K07496 PSORT swissprot:INSQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSQ_ECOLI PSORT-B swissprot:INSQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSQ_ECOLI PSORT2 swissprot:INSQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSQ_ECOLI Pfam PF01385 http://pfam.xfam.org/family/PF01385 Pfam PF07282 http://pfam.xfam.org/family/PF07282 Pfam PF12323 http://pfam.xfam.org/family/PF12323 Phobius swissprot:INSQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSQ_ECOLI PhylomeDB P76102 http://phylomedb.org/?seqid=P76102 ProteinModelPortal P76102 http://www.proteinmodelportal.org/query/uniprot/P76102 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415949 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415949 RefSeq WP_001251043 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001251043 STRING 511145.b1432 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1432&targetmode=cogs STRING COG0675 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0675&targetmode=cogs TIGRFAMs TIGR01766 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01766 UniProtKB INSQ_ECOLI http://www.uniprot.org/uniprot/INSQ_ECOLI UniProtKB-AC P76102 http://www.uniprot.org/uniprot/P76102 charge swissprot:INSQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSQ_ECOLI eggNOG COG0675 http://eggnogapi.embl.de/nog_data/html/tree/COG0675 eggNOG ENOG4105D7V http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D7V epestfind swissprot:INSQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSQ_ECOLI garnier swissprot:INSQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSQ_ECOLI helixturnhelix swissprot:INSQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSQ_ECOLI hmoment swissprot:INSQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSQ_ECOLI iep swissprot:INSQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSQ_ECOLI inforesidue swissprot:INSQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSQ_ECOLI octanol swissprot:INSQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSQ_ECOLI pepcoil swissprot:INSQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSQ_ECOLI pepdigest swissprot:INSQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSQ_ECOLI pepinfo swissprot:INSQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSQ_ECOLI pepnet swissprot:INSQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSQ_ECOLI pepstats swissprot:INSQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSQ_ECOLI pepwheel swissprot:INSQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSQ_ECOLI pepwindow swissprot:INSQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSQ_ECOLI sigcleave swissprot:INSQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSQ_ECOLI ## Database ID URL or Descriptions # BRENDA 2.7.1.17 2026 # BioGrid 4262539 5 # CATALYTIC ACTIVITY XYLB_ECOLI ATP + D-xylulose = ADP + D-xylulose 5- phosphate. # EcoGene EG11075 xylB # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0004856 xylulokinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0005998 xylulose catabolic process; IMP:EcoCyc. # GO_process GO:0042843 D-xylose catabolic process; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # InterPro IPR000577 Carb_kinase_FGGY # InterPro IPR006000 Xylulokinase # InterPro IPR018483 Carb_kinase_FGGY_CS # InterPro IPR018484 Carb_kinase_FGGY_N # InterPro IPR018485 Carb_kinase_FGGY_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00040 Pentose and glucuronate interconversions # Organism XYLB_ECOLI Escherichia coli (strain K12) # PATRIC 32122604 VBIEscCol129921_3679 # PDB 2ITM X-ray; 2.10 A; A/B=1-484 # PDB 2NLX X-ray; 2.70 A; A/B=1-484 # PIR A30266 KIECXY # PIRSF PIRSF000538 GlpK # PROSITE PS00445 FGGY_KINASES_2 # PROSITE PS00933 FGGY_KINASES_1 # Pfam PF00370 FGGY_N # Pfam PF02782 FGGY_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName XYLB_ECOLI Xylulose kinase # RefSeq NP_418021 NC_000913.3 # RefSeq WP_000275334 NZ_CP014272.1 # SIMILARITY Belongs to the FGGY kinase family. {ECO 0000305}. # TIGRFAMs TIGR01312 XylB # eggNOG COG1070 LUCA # eggNOG ENOG4105CMG Bacteria BLAST swissprot:XYLB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:XYLB_ECOLI BioCyc ECOL316407:JW3536-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3536-MONOMER BioCyc EcoCyc:XYLULOKIN-MONOMER http://biocyc.org/getid?id=EcoCyc:XYLULOKIN-MONOMER BioCyc MetaCyc:XYLULOKIN-MONOMER http://biocyc.org/getid?id=MetaCyc:XYLULOKIN-MONOMER COG COG1070 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1070 DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.17 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.17 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K01996 http://www.ebi.ac.uk/ena/data/view/K01996 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X04691 http://www.ebi.ac.uk/ena/data/view/X04691 ENZYME 2.7.1.17 http://enzyme.expasy.org/EC/2.7.1.17 EchoBASE EB1068 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1068 EcoGene EG11075 http://www.ecogene.org/geneInfo.php?eg_id=EG11075 EnsemblBacteria AAC76588 http://www.ensemblgenomes.org/id/AAC76588 EnsemblBacteria AAC76588 http://www.ensemblgenomes.org/id/AAC76588 EnsemblBacteria BAE77729 http://www.ensemblgenomes.org/id/BAE77729 EnsemblBacteria BAE77729 http://www.ensemblgenomes.org/id/BAE77729 EnsemblBacteria BAE77729 http://www.ensemblgenomes.org/id/BAE77729 EnsemblBacteria b3564 http://www.ensemblgenomes.org/id/b3564 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004856 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004856 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0005998 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005998 GO_process GO:0042843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042843 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 948133 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948133 HOGENOM HOG000222138 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000222138&db=HOGENOM6 InParanoid P09099 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P09099 IntAct P09099 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P09099* IntEnz 2.7.1.17 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.17 InterPro IPR000577 http://www.ebi.ac.uk/interpro/entry/IPR000577 InterPro IPR006000 http://www.ebi.ac.uk/interpro/entry/IPR006000 InterPro IPR018483 http://www.ebi.ac.uk/interpro/entry/IPR018483 InterPro IPR018484 http://www.ebi.ac.uk/interpro/entry/IPR018484 InterPro IPR018485 http://www.ebi.ac.uk/interpro/entry/IPR018485 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3536 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3536 KEGG_Gene eco:b3564 http://www.genome.jp/dbget-bin/www_bget?eco:b3564 KEGG_Orthology KO:K00854 http://www.genome.jp/dbget-bin/www_bget?KO:K00854 KEGG_Pathway ko00040 http://www.genome.jp/kegg-bin/show_pathway?ko00040 KEGG_Reaction rn:R01639 http://www.genome.jp/dbget-bin/www_bget?rn:R01639 OMA EITGNLM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EITGNLM PDB 2ITM http://www.ebi.ac.uk/pdbe-srv/view/entry/2ITM PDB 2NLX http://www.ebi.ac.uk/pdbe-srv/view/entry/2NLX PDBsum 2ITM http://www.ebi.ac.uk/pdbsum/2ITM PDBsum 2NLX http://www.ebi.ac.uk/pdbsum/2NLX PROSITE PS00445 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00445 PROSITE PS00933 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00933 PSORT swissprot:XYLB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:XYLB_ECOLI PSORT-B swissprot:XYLB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:XYLB_ECOLI PSORT2 swissprot:XYLB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:XYLB_ECOLI Pfam PF00370 http://pfam.xfam.org/family/PF00370 Pfam PF02782 http://pfam.xfam.org/family/PF02782 Phobius swissprot:XYLB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:XYLB_ECOLI PhylomeDB P09099 http://phylomedb.org/?seqid=P09099 ProteinModelPortal P09099 http://www.proteinmodelportal.org/query/uniprot/P09099 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6320721 http://www.ncbi.nlm.nih.gov/pubmed/6320721 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_418021 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418021 RefSeq WP_000275334 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000275334 SMR P09099 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P09099 STRING 511145.b3564 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3564&targetmode=cogs STRING COG1070 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1070&targetmode=cogs TIGRFAMs TIGR01312 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01312 UniProtKB XYLB_ECOLI http://www.uniprot.org/uniprot/XYLB_ECOLI UniProtKB-AC P09099 http://www.uniprot.org/uniprot/P09099 charge swissprot:XYLB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:XYLB_ECOLI eggNOG COG1070 http://eggnogapi.embl.de/nog_data/html/tree/COG1070 eggNOG ENOG4105CMG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CMG epestfind swissprot:XYLB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:XYLB_ECOLI garnier swissprot:XYLB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:XYLB_ECOLI helixturnhelix swissprot:XYLB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:XYLB_ECOLI hmoment swissprot:XYLB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:XYLB_ECOLI iep swissprot:XYLB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:XYLB_ECOLI inforesidue swissprot:XYLB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:XYLB_ECOLI octanol swissprot:XYLB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:XYLB_ECOLI pepcoil swissprot:XYLB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:XYLB_ECOLI pepdigest swissprot:XYLB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:XYLB_ECOLI pepinfo swissprot:XYLB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:XYLB_ECOLI pepnet swissprot:XYLB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:XYLB_ECOLI pepstats swissprot:XYLB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:XYLB_ECOLI pepwheel swissprot:XYLB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:XYLB_ECOLI pepwindow swissprot:XYLB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:XYLB_ECOLI sigcleave swissprot:XYLB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:XYLB_ECOLI ## Database ID URL or Descriptions # BioGrid 4261994 426 # DISRUPTION PHENOTYPE Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain. {ECO:0000269|PubMed 20345943}. # EcoGene EG12776 yraK # FUNCTION YRAK_ECOLI Part of the yraHIJK fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim operon. {ECO 0000269|PubMed 20345943}. # GO_component GO:0009289 pilus; IEA:UniProtKB-SubCell. # GO_process GO:0043709 cell adhesion involved in single-species biofilm formation; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0007155 cell adhesion # INDUCTION Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression. {ECO:0000269|PubMed 20345943}. # InterPro IPR000259 Adhesion_dom_fimbrial # InterPro IPR008966 Adhesion_dom # MISCELLANEOUS The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed. {ECO:0000305|PubMed 20345943}. # Organism YRAK_ECOLI Escherichia coli (strain K12) # PATRIC 32121708 VBIEscCol129921_3240 # PIR E65104 E65104 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF00419 Fimbrial # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YRAK_ECOLI Uncharacterized fimbrial-like protein YraK # RefSeq NP_417614 NC_000913.3 # RefSeq WP_000816992 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA57948.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the fimbrial protein family. {ECO 0000305}. # SUBCELLULAR LOCATION YRAK_ECOLI Fimbrium {ECO 0000305}. # SUPFAM SSF49401 SSF49401 # eggNOG ENOG4105I74 Bacteria # eggNOG ENOG4111TBD LUCA BLAST swissprot:YRAK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YRAK_ECOLI BioCyc ECOL316407:JW3114-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3114-MONOMER BioCyc EcoCyc:G7640-MONOMER http://biocyc.org/getid?id=EcoCyc:G7640-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1462-2920.2010.02202.x http://dx.doi.org/10.1111/j.1462-2920.2010.02202.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2629 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2629 EcoGene EG12776 http://www.ecogene.org/geneInfo.php?eg_id=EG12776 EnsemblBacteria AAC76179 http://www.ensemblgenomes.org/id/AAC76179 EnsemblBacteria AAC76179 http://www.ensemblgenomes.org/id/AAC76179 EnsemblBacteria BAE77191 http://www.ensemblgenomes.org/id/BAE77191 EnsemblBacteria BAE77191 http://www.ensemblgenomes.org/id/BAE77191 EnsemblBacteria BAE77191 http://www.ensemblgenomes.org/id/BAE77191 EnsemblBacteria b3145 http://www.ensemblgenomes.org/id/b3145 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009289 GO_process GO:0043709 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043709 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GeneID 947654 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947654 HOGENOM HOG000009602 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009602&db=HOGENOM6 InterPro IPR000259 http://www.ebi.ac.uk/interpro/entry/IPR000259 InterPro IPR008966 http://www.ebi.ac.uk/interpro/entry/IPR008966 KEGG_Gene ecj:JW3114 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3114 KEGG_Gene eco:b3145 http://www.genome.jp/dbget-bin/www_bget?eco:b3145 OMA NISMTAY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NISMTAY PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YRAK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YRAK_ECOLI PSORT-B swissprot:YRAK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YRAK_ECOLI PSORT2 swissprot:YRAK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YRAK_ECOLI Pfam PF00419 http://pfam.xfam.org/family/PF00419 Phobius swissprot:YRAK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YRAK_ECOLI PhylomeDB P43319 http://phylomedb.org/?seqid=P43319 ProteinModelPortal P43319 http://www.proteinmodelportal.org/query/uniprot/P43319 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20345943 http://www.ncbi.nlm.nih.gov/pubmed/20345943 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417614 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417614 RefSeq WP_000816992 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000816992 STRING 511145.b3145 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3145&targetmode=cogs SUPFAM SSF49401 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49401 UniProtKB YRAK_ECOLI http://www.uniprot.org/uniprot/YRAK_ECOLI UniProtKB-AC P43319 http://www.uniprot.org/uniprot/P43319 charge swissprot:YRAK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YRAK_ECOLI eggNOG ENOG4105I74 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105I74 eggNOG ENOG4111TBD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111TBD epestfind swissprot:YRAK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YRAK_ECOLI garnier swissprot:YRAK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YRAK_ECOLI helixturnhelix swissprot:YRAK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YRAK_ECOLI hmoment swissprot:YRAK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YRAK_ECOLI iep swissprot:YRAK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YRAK_ECOLI inforesidue swissprot:YRAK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YRAK_ECOLI octanol swissprot:YRAK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YRAK_ECOLI pepcoil swissprot:YRAK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YRAK_ECOLI pepdigest swissprot:YRAK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YRAK_ECOLI pepinfo swissprot:YRAK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YRAK_ECOLI pepnet swissprot:YRAK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YRAK_ECOLI pepstats swissprot:YRAK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YRAK_ECOLI pepwheel swissprot:YRAK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YRAK_ECOLI pepwindow swissprot:YRAK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YRAK_ECOLI sigcleave swissprot:YRAK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YRAK_ECOLI ## Database ID URL or Descriptions # BioGrid 4262163 138 # EcoGene EG13590 yahF # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0009361 succinate-CoA ligase complex (ADP-forming); IBA:GO_Central. # GO_function GO:0004775 succinate-CoA ligase (ADP-forming) activity; IBA:GO_Central. # GO_function GO:0048037 cofactor binding; IEA:InterPro. # GO_process GO:0006099 tricarboxylic acid cycle; IBA:GO_Central. # GO_process GO:0006104 succinyl-CoA metabolic process; IBA:GO_Central. # GO_process GO:0006105 succinate metabolic process; IBA:GO_Central. # GO_process GO:0009142 nucleoside triphosphate biosynthetic process; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016874 ligase activity # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.261 -; 1. # Gene3D 3.40.50.720 -; 1. # IntAct P77187 5 # InterPro IPR003781 CoA-bd # InterPro IPR005811 CoA_ligase # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR016102 Succinyl-CoA_synth-like # Organism YAHF_ECOLI Escherichia coli (strain K12) # PATRIC 32115769 VBIEscCol129921_0327 # PIR H64758 H64758 # Pfam PF00549 Ligase_CoA # Pfam PF02629 CoA_binding # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAHF_ECOLI Uncharacterized protein YahF # RefSeq NP_414854 NC_000913.3 # RefSeq WP_000111836 NZ_LN832404.1 # SIMILARITY To E.coli FdrA and some, to bacterial SucD. {ECO 0000305}. # SUPFAM SSF52210 SSF52210; 2 # eggNOG COG0074 LUCA # eggNOG ENOG4107R1Q Bacteria BLAST swissprot:YAHF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAHF_ECOLI BioCyc ECOL316407:JW0312-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0312-MONOMER BioCyc EcoCyc:G6185-MONOMER http://biocyc.org/getid?id=EcoCyc:G6185-MONOMER DIP DIP-11258N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11258N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB3360 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3360 EcoGene EG13590 http://www.ecogene.org/geneInfo.php?eg_id=EG13590 EnsemblBacteria AAC73423 http://www.ensemblgenomes.org/id/AAC73423 EnsemblBacteria AAC73423 http://www.ensemblgenomes.org/id/AAC73423 EnsemblBacteria BAE76103 http://www.ensemblgenomes.org/id/BAE76103 EnsemblBacteria BAE76103 http://www.ensemblgenomes.org/id/BAE76103 EnsemblBacteria BAE76103 http://www.ensemblgenomes.org/id/BAE76103 EnsemblBacteria b0320 http://www.ensemblgenomes.org/id/b0320 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0009361 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009361 GO_function GO:0004775 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004775 GO_function GO:0048037 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048037 GO_process GO:0006099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006099 GO_process GO:0006104 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006104 GO_process GO:0006105 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006105 GO_process GO:0009142 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009142 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.261 http://www.cathdb.info/version/latest/superfamily/3.40.50.261 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 947298 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947298 HOGENOM HOG000117378 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117378&db=HOGENOM6 IntAct P77187 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77187* InterPro IPR003781 http://www.ebi.ac.uk/interpro/entry/IPR003781 InterPro IPR005811 http://www.ebi.ac.uk/interpro/entry/IPR005811 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR016102 http://www.ebi.ac.uk/interpro/entry/IPR016102 KEGG_Gene ecj:JW0312 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0312 KEGG_Gene eco:b0320 http://www.genome.jp/dbget-bin/www_bget?eco:b0320 MINT MINT-1241539 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1241539 OMA KKNTYFD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KKNTYFD PSORT swissprot:YAHF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAHF_ECOLI PSORT-B swissprot:YAHF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAHF_ECOLI PSORT2 swissprot:YAHF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAHF_ECOLI Pfam PF00549 http://pfam.xfam.org/family/PF00549 Pfam PF02629 http://pfam.xfam.org/family/PF02629 Phobius swissprot:YAHF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAHF_ECOLI PhylomeDB P77187 http://phylomedb.org/?seqid=P77187 ProteinModelPortal P77187 http://www.proteinmodelportal.org/query/uniprot/P77187 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414854 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414854 RefSeq WP_000111836 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000111836 SMR P77187 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77187 STRING 511145.b0320 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0320&targetmode=cogs SUPFAM SSF52210 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52210 UniProtKB YAHF_ECOLI http://www.uniprot.org/uniprot/YAHF_ECOLI UniProtKB-AC P77187 http://www.uniprot.org/uniprot/P77187 charge swissprot:YAHF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAHF_ECOLI eggNOG COG0074 http://eggnogapi.embl.de/nog_data/html/tree/COG0074 eggNOG ENOG4107R1Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107R1Q epestfind swissprot:YAHF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAHF_ECOLI garnier swissprot:YAHF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAHF_ECOLI helixturnhelix swissprot:YAHF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAHF_ECOLI hmoment swissprot:YAHF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAHF_ECOLI iep swissprot:YAHF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAHF_ECOLI inforesidue swissprot:YAHF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAHF_ECOLI octanol swissprot:YAHF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAHF_ECOLI pepcoil swissprot:YAHF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAHF_ECOLI pepdigest swissprot:YAHF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAHF_ECOLI pepinfo swissprot:YAHF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAHF_ECOLI pepnet swissprot:YAHF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAHF_ECOLI pepstats swissprot:YAHF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAHF_ECOLI pepwheel swissprot:YAHF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAHF_ECOLI pepwindow swissprot:YAHF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAHF_ECOLI sigcleave swissprot:YAHF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAHF_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES FADB_ECOLI Kinetic parameters KM=53 uM for crotonyl-CoA (for enoyl-CoA hydratase activity) {ECO 0000269|PubMed 1748662, ECO 0000269|PubMed 8454629, ECO 0000269|PubMed 8755745}; KM=8.7 mM for L-3-hydroxy-4-trans-decenoyl-CoA (for enoyl-CoA hydratase activity) {ECO 0000269|PubMed 1748662, ECO 0000269|PubMed 8454629, ECO 0000269|PubMed 8755745}; KM=38 mM for D-3-hydroxy-4-trans-decenoyl-CoA (for enoyl-CoA hydratase activity) {ECO 0000269|PubMed 1748662, ECO 0000269|PubMed 8454629, ECO 0000269|PubMed 8755745}; KM=5.8 uM for 3-cis-tetradecenoyl-CoA (for Delta(3)-cis- Delta(2)-trans-enoyl-CoA isomerase activity) {ECO 0000269|PubMed 1748662, ECO 0000269|PubMed 8454629, ECO 0000269|PubMed 8755745}; KM=69 uM for acetoacetyl-CoA (for 3-hydroxyacyl-CoA dehydrogenase activity) {ECO 0000269|PubMed 1748662, ECO 0000269|PubMed 8454629, ECO 0000269|PubMed 8755745}; KM=2.0 uM for NADH (for 3-hydroxyacyl-CoA dehydrogenase activity) {ECO 0000269|PubMed 1748662, ECO 0000269|PubMed 8454629, ECO 0000269|PubMed 8755745}; # BioGrid 4263448 158 # CATALYTIC ACTIVITY (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl- CoA + H(2)O. {ECO:0000255|HAMAP-Rule MF_01621}. # CATALYTIC ACTIVITY (3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl- CoA. {ECO:0000255|HAMAP-Rule MF_01621}. # CATALYTIC ACTIVITY (S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH. {ECO:0000255|HAMAP-Rule MF_01621}. # CATALYTIC ACTIVITY (S)-3-hydroxybutanoyl-CoA = (R)-3- hydroxybutanoyl-CoA. {ECO:0000255|HAMAP-Rule MF_01621}. # EcoGene EG10279 fadB # FUNCTION FADB_ECOLI Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. {ECO 0000255|HAMAP-Rule MF_01621, ECO 0000269|PubMed 12535077, ECO 0000269|PubMed 1748662, ECO 0000269|PubMed 368024, ECO 0000269|PubMed 8454629, ECO 0000269|PubMed 8755745}. # GO_component GO:0036125 fatty acid beta-oxidation multienzyme complex; IEA:InterPro. # GO_function GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity; IDA:UniProtKB. # GO_function GO:0004165 dodecenoyl-CoA delta-isomerase activity; IDA:UniProtKB. # GO_function GO:0004300 enoyl-CoA hydratase activity; IDA:UniProtKB. # GO_function GO:0008692 3-hydroxybutyryl-CoA epimerase activity; IDA:UniProtKB. # GO_process GO:0006635 fatty acid beta-oxidation; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.1040.10 -; 2. # Gene3D 3.40.50.720 -; 1. # Gene3D 3.90.226.10 -; 2. # HAMAP MF_01621 FadB # INDUCTION FADB_ECOLI Repressed by FadR in the absence of LCFAs (fatty acids of, at least, 12 carbon atoms). When LCFAs are present in the medium, they are converted to long-chain acyl-CoAs which bind to FadR resulting in its release from the DNA and thus derepression of the transcription. # IntAct P21177 7 # InterPro IPR001753 Crotonase_core_superfam # InterPro IPR006108 3HC_DH_C # InterPro IPR006176 3-OHacyl-CoA_DH_NAD-bd # InterPro IPR006180 3-OHacyl-CoA_DH_CS # InterPro IPR008927 6-PGluconate_DH_C-like # InterPro IPR012799 FadB # InterPro IPR013328 6PGD_dom_2 # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR018376 Enoyl-CoA_hyd/isom_CS # InterPro IPR029045 ClpP/crotonase-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00071 Fatty acid metabolism # KEGG_Pathway ko00280 Valine, leucine and isoleucine degradation # KEGG_Pathway ko00281 Geraniol degradation # KEGG_Pathway ko00310 Lysine degradation # KEGG_Pathway ko00380 Tryptophan metabolism # KEGG_Pathway ko00410 beta-Alanine metabolism # KEGG_Pathway ko00640 Propanoate metabolism # KEGG_Pathway ko00650 Butanoate metabolism # KEGG_Pathway ko00720 Carbon fixation pathways in prokaryotes # KEGG_Pathway ko00903 Limonene and pinene degradation # KEGG_Pathway ko00930 Caprolactam degradation # KEGG_Pathway ko01040 Biosynthesis of unsaturated fatty acids # Organism FADB_ECOLI Escherichia coli (strain K12) # PATHWAY Lipid metabolism; fatty acid beta-oxidation. {ECO:0000255|HAMAP-Rule MF_01621}. # PATRIC 32123189 VBIEscCol129921_3960 # PIR A39592 A39592 # PROSITE PS00067 3HCDH # PROSITE PS00166 ENOYL_COA_HYDRATASE # Pfam PF00378 ECH_1 # Pfam PF00725 3HCDH; 2 # Pfam PF02737 3HCDH_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 3-hydroxyacyl-CoA dehydrogenase {ECO:0000255|HAMAP-Rule MF_01621} # RecName Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase/3-hydroxybutyryl-CoA epimerase {ECO:0000255|HAMAP-Rule MF_01621} # RecName Fatty acid oxidation complex subunit alpha {ECO:0000255|HAMAP-Rule MF_01621} # RecName Fatty acid oxidation complex subunit alpha {ECO:0000255|HAMAP-Rule MF_01621} # RefSeq NP_418288 NC_000913.3 # RefSeq WP_000965936 NZ_LN832404.1 # SIMILARITY In the C-terminal section; belongs to the 3- hydroxyacyl-CoA dehydrogenase family. {ECO:0000255|HAMAP- Rule MF_01621}. # SIMILARITY In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. {ECO:0000255|HAMAP-Rule MF_01621}. # SUBUNIT FADB_ECOLI Heterotetramer of two alpha chains (FadB) and two beta chains (FadA). {ECO 0000255|HAMAP-Rule MF_01621, ECO 0000269|PubMed 368024}. # SUPFAM SSF48179 SSF48179; 2 # SUPFAM SSF51735 SSF51735 # SUPFAM SSF52096 SSF52096 # TIGRFAMs TIGR02437 FadB # eggNOG COG1024 LUCA # eggNOG COG1250 LUCA # eggNOG ENOG4105DYT Bacteria BLAST swissprot:FADB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FADB_ECOLI BioCyc ECOL316407:JW3822-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3822-MONOMER BioCyc EcoCyc:FADB-MONOMER http://biocyc.org/getid?id=EcoCyc:FADB-MONOMER BioCyc MetaCyc:FADB-MONOMER http://biocyc.org/getid?id=MetaCyc:FADB-MONOMER COG COG1024 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1024 COG COG1250 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1250 DIP DIP-9560N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9560N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1021/bi00241a023 http://dx.doi.org/10.1021/bi00241a023 DOI 10.1021/bi960374y http://dx.doi.org/10.1021/bi960374y DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2003.03341.x http://dx.doi.org/10.1046/j.1365-2958.2003.03341.x DOI 10.1093/nar/18.16.4937 http://dx.doi.org/10.1093/nar/18.16.4937 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.35 {ECO:0000255|HAMAP-Rule:MF_01621} http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.35 {ECO:0000255|HAMAP-Rule:MF_01621} EC_number EC:4.2.1.17 {ECO:0000255|HAMAP-Rule:MF_01621} http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.17 {ECO:0000255|HAMAP-Rule:MF_01621} EC_number EC:5.1.2.3 {ECO:0000255|HAMAP-Rule:MF_01621} http://www.genome.jp/dbget-bin/www_bget?EC:5.1.2.3 {ECO:0000255|HAMAP-Rule:MF_01621} EC_number EC:5.3.3.8 {ECO:0000255|HAMAP-Rule:MF_01621} http://www.genome.jp/dbget-bin/www_bget?EC:5.3.3.8 {ECO:0000255|HAMAP-Rule:MF_01621} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M59368 http://www.ebi.ac.uk/ena/data/view/M59368 EMBL M74164 http://www.ebi.ac.uk/ena/data/view/M74164 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X52837 http://www.ebi.ac.uk/ena/data/view/X52837 ENZYME 1.1.1.35 {ECO:0000255|HAMAP-Rule:MF_01621} http://enzyme.expasy.org/EC/1.1.1.35 {ECO:0000255|HAMAP-Rule:MF_01621} ENZYME 4.2.1.17 {ECO:0000255|HAMAP-Rule:MF_01621} http://enzyme.expasy.org/EC/4.2.1.17 {ECO:0000255|HAMAP-Rule:MF_01621} ENZYME 5.1.2.3 {ECO:0000255|HAMAP-Rule:MF_01621} http://enzyme.expasy.org/EC/5.1.2.3 {ECO:0000255|HAMAP-Rule:MF_01621} ENZYME 5.3.3.8 {ECO:0000255|HAMAP-Rule:MF_01621} http://enzyme.expasy.org/EC/5.3.3.8 {ECO:0000255|HAMAP-Rule:MF_01621} EchoBASE EB0275 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0275 EcoGene EG10279 http://www.ecogene.org/geneInfo.php?eg_id=EG10279 EnsemblBacteria AAC76849 http://www.ensemblgenomes.org/id/AAC76849 EnsemblBacteria AAC76849 http://www.ensemblgenomes.org/id/AAC76849 EnsemblBacteria BAE77457 http://www.ensemblgenomes.org/id/BAE77457 EnsemblBacteria BAE77457 http://www.ensemblgenomes.org/id/BAE77457 EnsemblBacteria BAE77457 http://www.ensemblgenomes.org/id/BAE77457 EnsemblBacteria b3846 http://www.ensemblgenomes.org/id/b3846 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0036125 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036125 GO_function GO:0003857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003857 GO_function GO:0004165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004165 GO_function GO:0004300 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004300 GO_function GO:0008692 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008692 GO_process GO:0006635 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006635 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.1040.10 http://www.cathdb.info/version/latest/superfamily/1.10.1040.10 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 Gene3D 3.90.226.10 http://www.cathdb.info/version/latest/superfamily/3.90.226.10 GeneID 948336 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948336 HAMAP MF_01621 http://hamap.expasy.org/unirule/MF_01621 HOGENOM HOG000261344 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261344&db=HOGENOM6 InParanoid P21177 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P21177 IntAct P21177 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P21177* IntEnz 1.1.1.35 {ECO:0000255|HAMAP-Rule:MF_01621} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.35 {ECO:0000255|HAMAP-Rule:MF_01621} IntEnz 4.2.1.17 {ECO:0000255|HAMAP-Rule:MF_01621} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.17 {ECO:0000255|HAMAP-Rule:MF_01621} IntEnz 5.1.2.3 {ECO:0000255|HAMAP-Rule:MF_01621} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.1.2.3 {ECO:0000255|HAMAP-Rule:MF_01621} IntEnz 5.3.3.8 {ECO:0000255|HAMAP-Rule:MF_01621} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.3.3.8 {ECO:0000255|HAMAP-Rule:MF_01621} InterPro IPR001753 http://www.ebi.ac.uk/interpro/entry/IPR001753 InterPro IPR006108 http://www.ebi.ac.uk/interpro/entry/IPR006108 InterPro IPR006176 http://www.ebi.ac.uk/interpro/entry/IPR006176 InterPro IPR006180 http://www.ebi.ac.uk/interpro/entry/IPR006180 InterPro IPR008927 http://www.ebi.ac.uk/interpro/entry/IPR008927 InterPro IPR012799 http://www.ebi.ac.uk/interpro/entry/IPR012799 InterPro IPR013328 http://www.ebi.ac.uk/interpro/entry/IPR013328 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR018376 http://www.ebi.ac.uk/interpro/entry/IPR018376 InterPro IPR029045 http://www.ebi.ac.uk/interpro/entry/IPR029045 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3822 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3822 KEGG_Gene eco:b3846 http://www.genome.jp/dbget-bin/www_bget?eco:b3846 KEGG_Orthology KO:K01825 http://www.genome.jp/dbget-bin/www_bget?KO:K01825 KEGG_Pathway ko00071 http://www.genome.jp/kegg-bin/show_pathway?ko00071 KEGG_Pathway ko00280 http://www.genome.jp/kegg-bin/show_pathway?ko00280 KEGG_Pathway ko00281 http://www.genome.jp/kegg-bin/show_pathway?ko00281 KEGG_Pathway ko00310 http://www.genome.jp/kegg-bin/show_pathway?ko00310 KEGG_Pathway ko00380 http://www.genome.jp/kegg-bin/show_pathway?ko00380 KEGG_Pathway ko00410 http://www.genome.jp/kegg-bin/show_pathway?ko00410 KEGG_Pathway ko00640 http://www.genome.jp/kegg-bin/show_pathway?ko00640 KEGG_Pathway ko00650 http://www.genome.jp/kegg-bin/show_pathway?ko00650 KEGG_Pathway ko00720 http://www.genome.jp/kegg-bin/show_pathway?ko00720 KEGG_Pathway ko00903 http://www.genome.jp/kegg-bin/show_pathway?ko00903 KEGG_Pathway ko00930 http://www.genome.jp/kegg-bin/show_pathway?ko00930 KEGG_Pathway ko01040 http://www.genome.jp/kegg-bin/show_pathway?ko01040 KEGG_Reaction rn:R01975 http://www.genome.jp/dbget-bin/www_bget?rn:R01975 KEGG_Reaction rn:R03026 http://www.genome.jp/dbget-bin/www_bget?rn:R03026 KEGG_Reaction rn:R03045 http://www.genome.jp/dbget-bin/www_bget?rn:R03045 KEGG_Reaction rn:R03276 http://www.genome.jp/dbget-bin/www_bget?rn:R03276 KEGG_Reaction rn:R04137 http://www.genome.jp/dbget-bin/www_bget?rn:R04137 KEGG_Reaction rn:R04170 http://www.genome.jp/dbget-bin/www_bget?rn:R04170 KEGG_Reaction rn:R04203 http://www.genome.jp/dbget-bin/www_bget?rn:R04203 KEGG_Reaction rn:R04204 http://www.genome.jp/dbget-bin/www_bget?rn:R04204 KEGG_Reaction rn:R04224 http://www.genome.jp/dbget-bin/www_bget?rn:R04224 KEGG_Reaction rn:R04737 http://www.genome.jp/dbget-bin/www_bget?rn:R04737 KEGG_Reaction rn:R04738 http://www.genome.jp/dbget-bin/www_bget?rn:R04738 KEGG_Reaction rn:R04739 http://www.genome.jp/dbget-bin/www_bget?rn:R04739 KEGG_Reaction rn:R04740 http://www.genome.jp/dbget-bin/www_bget?rn:R04740 KEGG_Reaction rn:R04741 http://www.genome.jp/dbget-bin/www_bget?rn:R04741 KEGG_Reaction rn:R04744 http://www.genome.jp/dbget-bin/www_bget?rn:R04744 KEGG_Reaction rn:R04745 http://www.genome.jp/dbget-bin/www_bget?rn:R04745 KEGG_Reaction rn:R04746 http://www.genome.jp/dbget-bin/www_bget?rn:R04746 KEGG_Reaction rn:R04748 http://www.genome.jp/dbget-bin/www_bget?rn:R04748 KEGG_Reaction rn:R04749 http://www.genome.jp/dbget-bin/www_bget?rn:R04749 KEGG_Reaction rn:R04756 http://www.genome.jp/dbget-bin/www_bget?rn:R04756 KEGG_Reaction rn:R05066 http://www.genome.jp/dbget-bin/www_bget?rn:R05066 KEGG_Reaction rn:R06411 http://www.genome.jp/dbget-bin/www_bget?rn:R06411 KEGG_Reaction rn:R06412 http://www.genome.jp/dbget-bin/www_bget?rn:R06412 KEGG_Reaction rn:R06941 http://www.genome.jp/dbget-bin/www_bget?rn:R06941 KEGG_Reaction rn:R06942 http://www.genome.jp/dbget-bin/www_bget?rn:R06942 KEGG_Reaction rn:R07935 http://www.genome.jp/dbget-bin/www_bget?rn:R07935 KEGG_Reaction rn:R07951 http://www.genome.jp/dbget-bin/www_bget?rn:R07951 KEGG_Reaction rn:R08093 http://www.genome.jp/dbget-bin/www_bget?rn:R08093 KEGG_Reaction rn:R08094 http://www.genome.jp/dbget-bin/www_bget?rn:R08094 OMA YKAKRQP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YKAKRQP PROSITE PS00067 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00067 PROSITE PS00166 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00166 PSORT swissprot:FADB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FADB_ECOLI PSORT-B swissprot:FADB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FADB_ECOLI PSORT2 swissprot:FADB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FADB_ECOLI Pfam PF00378 http://pfam.xfam.org/family/PF00378 Pfam PF00725 http://pfam.xfam.org/family/PF00725 Pfam PF02737 http://pfam.xfam.org/family/PF02737 Phobius swissprot:FADB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FADB_ECOLI PhylomeDB P21177 http://phylomedb.org/?seqid=P21177 ProteinModelPortal P21177 http://www.proteinmodelportal.org/query/uniprot/P21177 PubMed 12535077 http://www.ncbi.nlm.nih.gov/pubmed/12535077 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1699931 http://www.ncbi.nlm.nih.gov/pubmed/1699931 PubMed 1712230 http://www.ncbi.nlm.nih.gov/pubmed/1712230 PubMed 1748662 http://www.ncbi.nlm.nih.gov/pubmed/1748662 PubMed 2191949 http://www.ncbi.nlm.nih.gov/pubmed/2191949 PubMed 2204034 http://www.ncbi.nlm.nih.gov/pubmed/2204034 PubMed 368024 http://www.ncbi.nlm.nih.gov/pubmed/368024 PubMed 8454629 http://www.ncbi.nlm.nih.gov/pubmed/8454629 PubMed 8755745 http://www.ncbi.nlm.nih.gov/pubmed/8755745 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_418288 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418288 RefSeq WP_000965936 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000965936 SMR P21177 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P21177 STRING 511145.b3846 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3846&targetmode=cogs STRING COG1024 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1024&targetmode=cogs STRING COG1250 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1250&targetmode=cogs SUPFAM SSF48179 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48179 SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 SUPFAM SSF52096 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52096 TIGRFAMs TIGR02437 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02437 UniProtKB FADB_ECOLI http://www.uniprot.org/uniprot/FADB_ECOLI UniProtKB-AC P21177 http://www.uniprot.org/uniprot/P21177 charge swissprot:FADB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FADB_ECOLI eggNOG COG1024 http://eggnogapi.embl.de/nog_data/html/tree/COG1024 eggNOG COG1250 http://eggnogapi.embl.de/nog_data/html/tree/COG1250 eggNOG ENOG4105DYT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DYT epestfind swissprot:FADB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FADB_ECOLI garnier swissprot:FADB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FADB_ECOLI helixturnhelix swissprot:FADB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FADB_ECOLI hmoment swissprot:FADB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FADB_ECOLI iep swissprot:FADB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FADB_ECOLI inforesidue swissprot:FADB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FADB_ECOLI octanol swissprot:FADB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FADB_ECOLI pepcoil swissprot:FADB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FADB_ECOLI pepdigest swissprot:FADB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FADB_ECOLI pepinfo swissprot:FADB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FADB_ECOLI pepnet swissprot:FADB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FADB_ECOLI pepstats swissprot:FADB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FADB_ECOLI pepwheel swissprot:FADB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FADB_ECOLI pepwindow swissprot:FADB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FADB_ECOLI sigcleave swissprot:FADB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FADB_ECOLI ## Database ID URL or Descriptions # AltName ARNT_ECOLI 4-amino-4-deoxy-L-arabinose lipid A transferase # AltName ARNT_ECOLI Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase # AltName ARNT_ECOLI Polymyxin resistance protein PmrK # AltName ARNT_ECOLI Undecaprenyl phosphate-alpha-L-Ara4N transferase # BRENDA 2.4.2.43 2026 # BioGrid 4260499 144 # CATALYTIC ACTIVITY 4-amino-4-deoxy-alpha-L-arabinopyranosyl di- trans,octa-cis-undecaprenyl phosphate + lipid IV(A) = lipid II(A) + di-trans,octa-cis-undecaprenyl phosphate. {ECO:0000269|PubMed 11535604}. # CAZy GT83 Glycosyltransferase Family 83 # EcoGene EG14093 arnT # FUNCTION ARNT_ECOLI Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. {ECO 0000269|PubMed 11535604}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0000030 mannosyltransferase activity; IEA:InterPro. # GO_function GO:0016763 transferase activity, transferring pentosyl groups; IMP:EcoCyc. # GO_process GO:0006493 protein O-linked glycosylation; IEA:InterPro. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IMP:EcoCyc. # GO_process GO:0009245 lipid A biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0010041 response to iron(III) ion; IGI:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # HAMAP MF_01165 ArnT_transfer # INDUCTION Induced by BasR. {ECO 0000250}. # InterPro IPR003342 Glyco_trans_39/83 # InterPro IPR022839 ArnT_tfrase # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01003 Glycosyltransferases # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # Organism ARNT_ECOLI Escherichia coli (strain K12) # PATHWAY ARNT_ECOLI Lipopolysaccharide metabolism; 4-amino-4-deoxy-beta-L- arabinose-lipid A biosynthesis. # PATRIC 32119879 VBIEscCol129921_2349 # PIR G64996 G64996 # Pfam PF02366 PMT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ARNT_ECOLI Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase # RefSeq NP_416760 NC_000913.3 # RefSeq WP_000844057 NZ_LN832404.1 # SIMILARITY Belongs to the glycosyltransferase 83 family. {ECO 0000305}. # SUBCELLULAR LOCATION ARNT_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # TCDB 9.B.142.2 the integral membrane glycosyltransferase family 39 (gt39) family # eggNOG COG1807 LUCA # eggNOG ENOG4105SA9 Bacteria BLAST swissprot:ARNT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARNT_ECOLI BioCyc ECOL316407:JW2251-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2251-MONOMER BioCyc EcoCyc:G7170-MONOMER http://biocyc.org/getid?id=EcoCyc:G7170-MONOMER BioCyc MetaCyc:G7170-MONOMER http://biocyc.org/getid?id=MetaCyc:G7170-MONOMER COG COG1807 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M106961200 http://dx.doi.org/10.1074/jbc.M106961200 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.4.2.43 http://www.genome.jp/dbget-bin/www_bget?EC:2.4.2.43 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.4.2.43 http://enzyme.expasy.org/EC/2.4.2.43 EchoBASE EB3846 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3846 EcoGene EG14093 http://www.ecogene.org/geneInfo.php?eg_id=EG14093 EnsemblBacteria AAC75317 http://www.ensemblgenomes.org/id/AAC75317 EnsemblBacteria AAC75317 http://www.ensemblgenomes.org/id/AAC75317 EnsemblBacteria BAE76674 http://www.ensemblgenomes.org/id/BAE76674 EnsemblBacteria BAE76674 http://www.ensemblgenomes.org/id/BAE76674 EnsemblBacteria BAE76674 http://www.ensemblgenomes.org/id/BAE76674 EnsemblBacteria b2257 http://www.ensemblgenomes.org/id/b2257 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0000030 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000030 GO_function GO:0016763 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016763 GO_process GO:0006493 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006493 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GO_process GO:0009245 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009245 GO_process GO:0010041 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010041 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 947297 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947297 HAMAP MF_01165 http://hamap.expasy.org/unirule/MF_01165 HOGENOM HOG000273002 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000273002&db=HOGENOM6 InParanoid P76473 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76473 IntEnz 2.4.2.43 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.2.43 InterPro IPR003342 http://www.ebi.ac.uk/interpro/entry/IPR003342 InterPro IPR022839 http://www.ebi.ac.uk/interpro/entry/IPR022839 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01003 http://www.genome.jp/dbget-bin/www_bget?ko01003 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Gene ecj:JW2251 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2251 KEGG_Gene eco:b2257 http://www.genome.jp/dbget-bin/www_bget?eco:b2257 KEGG_Orthology KO:K07264 http://www.genome.jp/dbget-bin/www_bget?KO:K07264 KEGG_Reaction rn:R09773 http://www.genome.jp/dbget-bin/www_bget?rn:R09773 KEGG_Reaction rn:R09774 http://www.genome.jp/dbget-bin/www_bget?rn:R09774 OMA AWRIFRD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AWRIFRD PSORT swissprot:ARNT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARNT_ECOLI PSORT-B swissprot:ARNT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARNT_ECOLI PSORT2 swissprot:ARNT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARNT_ECOLI Pfam PF02366 http://pfam.xfam.org/family/PF02366 Phobius swissprot:ARNT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARNT_ECOLI PhylomeDB P76473 http://phylomedb.org/?seqid=P76473 ProteinModelPortal P76473 http://www.proteinmodelportal.org/query/uniprot/P76473 PubMed 11535604 http://www.ncbi.nlm.nih.gov/pubmed/11535604 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416760 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416760 RefSeq WP_000844057 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000844057 STRING 511145.b2257 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2257&targetmode=cogs STRING COG1807 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1807&targetmode=cogs TCDB 9.B.142.2 http://www.tcdb.org/search/result.php?tc=9.B.142.2 UniProtKB ARNT_ECOLI http://www.uniprot.org/uniprot/ARNT_ECOLI UniProtKB-AC P76473 http://www.uniprot.org/uniprot/P76473 charge swissprot:ARNT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARNT_ECOLI eggNOG COG1807 http://eggnogapi.embl.de/nog_data/html/tree/COG1807 eggNOG ENOG4105SA9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105SA9 epestfind swissprot:ARNT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARNT_ECOLI garnier swissprot:ARNT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARNT_ECOLI helixturnhelix swissprot:ARNT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARNT_ECOLI hmoment swissprot:ARNT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARNT_ECOLI iep swissprot:ARNT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARNT_ECOLI inforesidue swissprot:ARNT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARNT_ECOLI octanol swissprot:ARNT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARNT_ECOLI pepcoil swissprot:ARNT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARNT_ECOLI pepdigest swissprot:ARNT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARNT_ECOLI pepinfo swissprot:ARNT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARNT_ECOLI pepnet swissprot:ARNT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARNT_ECOLI pepstats swissprot:ARNT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARNT_ECOLI pepwheel swissprot:ARNT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARNT_ECOLI pepwindow swissprot:ARNT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARNT_ECOLI sigcleave swissprot:ARNT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARNT_ECOLI ## Database ID URL or Descriptions # AltName CYOC_ECOLI Cytochrome o ubiquinol oxidase subunit 3 # AltName CYOC_ECOLI Oxidase bo(3) subunit 3 # AltName CYOC_ECOLI Ubiquinol oxidase chain C # AltName CYOC_ECOLI Ubiquinol oxidase polypeptide III # AltName CYOC_ECOLI Ubiquinol oxidase subunit 3 # BioGrid 4261578 174 # CDD cd02863 Ubiquinol_oxidase_III # DISRUPTION PHENOTYPE CYOC_ECOLI Increased reduction of the ubiquinone pool (in aerobically grown minimal medium with glucose). {ECO 0000269|PubMed 19542282, ECO 0000269|PubMed 22843529}. # EcoGene EG10180 cyoC # FUNCTION CYOC_ECOLI Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron. {ECO 0000269|PubMed 19542282, ECO 0000269|PubMed 22843529, ECO 0000269|PubMed 6308657}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0009319 cytochrome o ubiquinol oxidase complex; IDA:EcoCyc. # GO_function GO:0004129 cytochrome-c oxidase activity; IEA:InterPro. # GO_function GO:0008827 cytochrome o ubiquinol oxidase activity; IEA:InterPro. # GO_function GO:0009055 electron carrier activity; IDA:EcoCyc. # GO_function GO:0009486 cytochrome bo3 ubiquinol oxidase activity; IDA:EcoCyc. # GO_function GO:0015078 hydrogen ion transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0015453 oxidoreduction-driven active transmembrane transporter activity; IDA:EcoCyc. # GO_process GO:0009060 aerobic respiration; IMP:EcoCyc. # GO_process GO:0015990 electron transport coupled proton transport; IDA:EcoCyc. # GO_process GO:0019646 aerobic electron transport chain; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0055085 transmembrane transport # Gene3D 1.20.120.80 -; 1. # InterPro IPR000298 Cyt_c_oxidase-like_su3 # InterPro IPR013833 Cyt_c_oxidase_su3_a-hlx # InterPro IPR014206 Cyt_c_ubiqinol_oxidase_su3 # InterPro IPR024791 Cyt_c/ubiquinol_Oxase_su3 # InterPro IPR033946 Ubiquinol_oxase_su3_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00190 Oxidative phosphorylation # Organism CYOC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11403 PTHR11403 # PATRIC 32116011 VBIEscCol129921_0447 # PDB 1FFT X-ray; 3.50 A; C/H=25-204 # PIR C42226 C42226 # PROSITE PS50253 COX3 # Pfam PF00510 COX3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CYOC_ECOLI Cytochrome bo(3) ubiquinol oxidase subunit 3 # RefSeq NP_414964 NC_000913.3 # RefSeq WP_000179819 NZ_LN832404.1 # SIMILARITY Belongs to the cytochrome c oxidase subunit 3 family. {ECO 0000305}. # SUBCELLULAR LOCATION CYOC_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT CYOC_ECOLI Heterooctamer of two A chains, two B chains, two C chains and two D chains. {ECO 0000269|PubMed 11017202, ECO 0000269|PubMed 6308657}. # SUPFAM SSF81452 SSF81452 # TCDB 3.D.4.5 the proton-translocating cytochrome oxidase (cox) superfamily # TIGRFAMs TIGR02842 CyoC # eggNOG COG1845 LUCA # eggNOG ENOG4105CCU Bacteria BLAST swissprot:CYOC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CYOC_ECOLI BioCyc ECOL316407:JW0420-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0420-MONOMER BioCyc EcoCyc:CYOC-MONOMER http://biocyc.org/getid?id=EcoCyc:CYOC-MONOMER BioCyc MetaCyc:CYOC-MONOMER http://biocyc.org/getid?id=MetaCyc:CYOC-MONOMER COG COG1845 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1845 DIP DIP-47944N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47944N DOI 10.1016/0005-2728(90)90231-R http://dx.doi.org/10.1016/0005-2728(90)90231-R DOI 10.1038/82824 http://dx.doi.org/10.1038/82824 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.80.16.4889 http://dx.doi.org/10.1073/pnas.80.16.4889 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AEM.01507-12 http://dx.doi.org/10.1128/AEM.01507-12 DOI 10.1128/JB.00562-09 http://dx.doi.org/10.1128/JB.00562-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J05492 http://www.ebi.ac.uk/ena/data/view/J05492 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EchoBASE EB0177 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0177 EcoGene EG10180 http://www.ecogene.org/geneInfo.php?eg_id=EG10180 EnsemblBacteria AAC73533 http://www.ensemblgenomes.org/id/AAC73533 EnsemblBacteria AAC73533 http://www.ensemblgenomes.org/id/AAC73533 EnsemblBacteria BAE76210 http://www.ensemblgenomes.org/id/BAE76210 EnsemblBacteria BAE76210 http://www.ensemblgenomes.org/id/BAE76210 EnsemblBacteria BAE76210 http://www.ensemblgenomes.org/id/BAE76210 EnsemblBacteria b0430 http://www.ensemblgenomes.org/id/b0430 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0009319 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009319 GO_function GO:0004129 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004129 GO_function GO:0008827 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008827 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0009486 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009486 GO_function GO:0015078 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015078 GO_function GO:0015453 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015453 GO_process GO:0009060 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009060 GO_process GO:0015990 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015990 GO_process GO:0019646 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019646 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 1.20.120.80 http://www.cathdb.info/version/latest/superfamily/1.20.120.80 GeneID 946897 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946897 HOGENOM HOG000086398 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000086398&db=HOGENOM6 InParanoid P0ABJ3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABJ3 IntAct P0ABJ3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABJ3* InterPro IPR000298 http://www.ebi.ac.uk/interpro/entry/IPR000298 InterPro IPR013833 http://www.ebi.ac.uk/interpro/entry/IPR013833 InterPro IPR014206 http://www.ebi.ac.uk/interpro/entry/IPR014206 InterPro IPR024791 http://www.ebi.ac.uk/interpro/entry/IPR024791 InterPro IPR033946 http://www.ebi.ac.uk/interpro/entry/IPR033946 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0420 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0420 KEGG_Gene eco:b0430 http://www.genome.jp/dbget-bin/www_bget?eco:b0430 KEGG_Orthology KO:K02299 http://www.genome.jp/dbget-bin/www_bget?KO:K02299 KEGG_Pathway ko00190 http://www.genome.jp/kegg-bin/show_pathway?ko00190 OMA YTELVKH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YTELVKH PANTHER PTHR11403 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11403 PDB 1FFT http://www.ebi.ac.uk/pdbe-srv/view/entry/1FFT PDBsum 1FFT http://www.ebi.ac.uk/pdbsum/1FFT PROSITE PS50253 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50253 PSORT swissprot:CYOC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CYOC_ECOLI PSORT-B swissprot:CYOC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CYOC_ECOLI PSORT2 swissprot:CYOC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CYOC_ECOLI Pfam PF00510 http://pfam.xfam.org/family/PF00510 Phobius swissprot:CYOC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CYOC_ECOLI PhylomeDB P0ABJ3 http://phylomedb.org/?seqid=P0ABJ3 ProteinModelPortal P0ABJ3 http://www.proteinmodelportal.org/query/uniprot/P0ABJ3 PubMed 11017202 http://www.ncbi.nlm.nih.gov/pubmed/11017202 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19542282 http://www.ncbi.nlm.nih.gov/pubmed/19542282 PubMed 2162835 http://www.ncbi.nlm.nih.gov/pubmed/2162835 PubMed 2165491 http://www.ncbi.nlm.nih.gov/pubmed/2165491 PubMed 2168206 http://www.ncbi.nlm.nih.gov/pubmed/2168206 PubMed 22843529 http://www.ncbi.nlm.nih.gov/pubmed/22843529 PubMed 6308657 http://www.ncbi.nlm.nih.gov/pubmed/6308657 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414964 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414964 RefSeq WP_000179819 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000179819 STRING 511145.b0430 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0430&targetmode=cogs STRING COG1845 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1845&targetmode=cogs SUPFAM SSF81452 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81452 TCDB 3.D.4.5 http://www.tcdb.org/search/result.php?tc=3.D.4.5 TIGRFAMs TIGR02842 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02842 UniProtKB CYOC_ECOLI http://www.uniprot.org/uniprot/CYOC_ECOLI UniProtKB-AC P0ABJ3 http://www.uniprot.org/uniprot/P0ABJ3 charge swissprot:CYOC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CYOC_ECOLI eggNOG COG1845 http://eggnogapi.embl.de/nog_data/html/tree/COG1845 eggNOG ENOG4105CCU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CCU epestfind swissprot:CYOC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CYOC_ECOLI garnier swissprot:CYOC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CYOC_ECOLI helixturnhelix swissprot:CYOC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CYOC_ECOLI hmoment swissprot:CYOC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CYOC_ECOLI iep swissprot:CYOC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CYOC_ECOLI inforesidue swissprot:CYOC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CYOC_ECOLI octanol swissprot:CYOC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CYOC_ECOLI pepcoil swissprot:CYOC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CYOC_ECOLI pepdigest swissprot:CYOC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CYOC_ECOLI pepinfo swissprot:CYOC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CYOC_ECOLI pepnet swissprot:CYOC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CYOC_ECOLI pepstats swissprot:CYOC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CYOC_ECOLI pepwheel swissprot:CYOC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CYOC_ECOLI pepwindow swissprot:CYOC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CYOC_ECOLI sigcleave swissprot:CYOC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CYOC_ECOLI ## Database ID URL or Descriptions # BioGrid 4262441 20 # EcoGene EG12813 yhcG # InterPro IPR009362 DUF1016 # Organism YHCG_ECOLI Escherichia coli (strain K12) # PATRIC 32121864 VBIEscCol129921_3316 # PIR F65113 F65113 # Pfam PF06250 DUF1016 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHCG_ECOLI Uncharacterized protein YhcG # RefSeq NP_417687 NC_000913.3 # RefSeq WP_000445111 NZ_LN832404.1 # eggNOG COG4804 LUCA # eggNOG ENOG4105DFS Bacteria BLAST swissprot:YHCG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHCG_ECOLI BioCyc ECOL316407:JW3189-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3189-MONOMER BioCyc EcoCyc:G7674-MONOMER http://biocyc.org/getid?id=EcoCyc:G7674-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2664 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2664 EcoGene EG12813 http://www.ecogene.org/geneInfo.php?eg_id=EG12813 EnsemblBacteria AAC76252 http://www.ensemblgenomes.org/id/AAC76252 EnsemblBacteria AAC76252 http://www.ensemblgenomes.org/id/AAC76252 EnsemblBacteria BAE77263 http://www.ensemblgenomes.org/id/BAE77263 EnsemblBacteria BAE77263 http://www.ensemblgenomes.org/id/BAE77263 EnsemblBacteria BAE77263 http://www.ensemblgenomes.org/id/BAE77263 EnsemblBacteria b3220 http://www.ensemblgenomes.org/id/b3220 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947739 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947739 HOGENOM HOG000097665 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000097665&db=HOGENOM6 InParanoid P45423 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45423 IntAct P45423 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45423* InterPro IPR009362 http://www.ebi.ac.uk/interpro/entry/IPR009362 KEGG_Gene ecj:JW3189 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3189 KEGG_Gene eco:b3220 http://www.genome.jp/dbget-bin/www_bget?eco:b3220 OMA TFVGRQR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TFVGRQR PSORT swissprot:YHCG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHCG_ECOLI PSORT-B swissprot:YHCG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHCG_ECOLI PSORT2 swissprot:YHCG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHCG_ECOLI Pfam PF06250 http://pfam.xfam.org/family/PF06250 Phobius swissprot:YHCG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHCG_ECOLI PhylomeDB P45423 http://phylomedb.org/?seqid=P45423 ProteinModelPortal P45423 http://www.proteinmodelportal.org/query/uniprot/P45423 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417687 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417687 RefSeq WP_000445111 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000445111 STRING 511145.b3220 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3220&targetmode=cogs UniProtKB YHCG_ECOLI http://www.uniprot.org/uniprot/YHCG_ECOLI UniProtKB-AC P45423 http://www.uniprot.org/uniprot/P45423 charge swissprot:YHCG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHCG_ECOLI eggNOG COG4804 http://eggnogapi.embl.de/nog_data/html/tree/COG4804 eggNOG ENOG4105DFS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DFS epestfind swissprot:YHCG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHCG_ECOLI garnier swissprot:YHCG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHCG_ECOLI helixturnhelix swissprot:YHCG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHCG_ECOLI hmoment swissprot:YHCG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHCG_ECOLI iep swissprot:YHCG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHCG_ECOLI inforesidue swissprot:YHCG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHCG_ECOLI octanol swissprot:YHCG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHCG_ECOLI pepcoil swissprot:YHCG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHCG_ECOLI pepdigest swissprot:YHCG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHCG_ECOLI pepinfo swissprot:YHCG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHCG_ECOLI pepnet swissprot:YHCG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHCG_ECOLI pepstats swissprot:YHCG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHCG_ECOLI pepwheel swissprot:YHCG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHCG_ECOLI pepwindow swissprot:YHCG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHCG_ECOLI sigcleave swissprot:YHCG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHCG_ECOLI ## Database ID URL or Descriptions # EcoGene EG14403 ldrA # EcoGene EG14405 ldrC # FUNCTION LDRA_ECOLI Toxic peptide whose overexpression causes rapid cell killing and nucleoid condensation of the host cell. {ECO 0000250}. # INDUCTION A type I toxin antitoxin (TA) system, where expression of the proteinaceous toxin is controlled by an antisense sRNA, in this case RdlA or RdlC. Only a few of these TA systems have been mechanistically characterized; the mechanisms used to control expression of the toxin gene are not necessarily the same (Probable). {ECO 0000305}. # InterPro IPR025253 Toxin_Ldr # Organism LDRA_ECOLI Escherichia coli (strain K12) # Pfam PF13940 Ldr_toxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LDRA_ECOLI Small toxic polypeptide LdrA/LdrC # RefSeq YP_025297 NC_000913.3 # RefSeq YP_025299 NC_000913.3 # SIMILARITY Belongs to the toxic peptide ldr family. {ECO 0000305}. BLAST swissprot:LDRA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LDRA_ECOLI BioCyc ECOL316407:JW5957-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5957-MONOMER BioCyc ECOL316407:JW5959-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5959-MONOMER BioCyc EcoCyc:MONOMER0-1601 http://biocyc.org/getid?id=EcoCyc:MONOMER0-1601 BioCyc EcoCyc:MONOMER0-1603 http://biocyc.org/getid?id=EcoCyc:MONOMER0-1603 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2002.03042.x http://dx.doi.org/10.1046/j.1365-2958.2002.03042.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14403 http://www.ecogene.org/geneInfo.php?eg_id=EG14403 EcoGene EG14405 http://www.ecogene.org/geneInfo.php?eg_id=EG14405 EnsemblBacteria AAT48126 http://www.ensemblgenomes.org/id/AAT48126 EnsemblBacteria AAT48126 http://www.ensemblgenomes.org/id/AAT48126 EnsemblBacteria AAT48128 http://www.ensemblgenomes.org/id/AAT48128 EnsemblBacteria AAT48128 http://www.ensemblgenomes.org/id/AAT48128 EnsemblBacteria BAE76392 http://www.ensemblgenomes.org/id/BAE76392 EnsemblBacteria BAE76392 http://www.ensemblgenomes.org/id/BAE76392 EnsemblBacteria BAE76392 http://www.ensemblgenomes.org/id/BAE76392 EnsemblBacteria BAE76394 http://www.ensemblgenomes.org/id/BAE76394 EnsemblBacteria BAE76394 http://www.ensemblgenomes.org/id/BAE76394 EnsemblBacteria BAE76394 http://www.ensemblgenomes.org/id/BAE76394 EnsemblBacteria b4419 http://www.ensemblgenomes.org/id/b4419 EnsemblBacteria b4423 http://www.ensemblgenomes.org/id/b4423 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 2847733 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2847733 GeneID 2847775 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2847775 HOGENOM HOG000125979 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125979&db=HOGENOM6 InterPro IPR025253 http://www.ebi.ac.uk/interpro/entry/IPR025253 KEGG_Gene ecj:JW5957 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5957 KEGG_Gene ecj:JW5959 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5959 KEGG_Gene eco:b4419 http://www.genome.jp/dbget-bin/www_bget?eco:b4419 KEGG_Gene eco:b4423 http://www.genome.jp/dbget-bin/www_bget?eco:b4423 PSORT swissprot:LDRA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LDRA_ECOLI PSORT-B swissprot:LDRA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LDRA_ECOLI PSORT2 swissprot:LDRA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LDRA_ECOLI Pfam PF13940 http://pfam.xfam.org/family/PF13940 Phobius swissprot:LDRA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LDRA_ECOLI PhylomeDB Q6BF86 http://phylomedb.org/?seqid=Q6BF86 ProteinModelPortal Q6BF86 http://www.proteinmodelportal.org/query/uniprot/Q6BF86 PubMed 12123448 http://www.ncbi.nlm.nih.gov/pubmed/12123448 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq YP_025297 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_025297 RefSeq YP_025299 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_025299 STRING 511145.b4423 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4423&targetmode=cogs UniProtKB LDRA_ECOLI http://www.uniprot.org/uniprot/LDRA_ECOLI UniProtKB-AC Q6BF86 http://www.uniprot.org/uniprot/Q6BF86 charge swissprot:LDRA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LDRA_ECOLI epestfind swissprot:LDRA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LDRA_ECOLI garnier swissprot:LDRA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LDRA_ECOLI helixturnhelix swissprot:LDRA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LDRA_ECOLI hmoment swissprot:LDRA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LDRA_ECOLI iep swissprot:LDRA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LDRA_ECOLI inforesidue swissprot:LDRA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LDRA_ECOLI octanol swissprot:LDRA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LDRA_ECOLI pepcoil swissprot:LDRA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LDRA_ECOLI pepdigest swissprot:LDRA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LDRA_ECOLI pepinfo swissprot:LDRA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LDRA_ECOLI pepnet swissprot:LDRA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LDRA_ECOLI pepstats swissprot:LDRA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LDRA_ECOLI pepwheel swissprot:LDRA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LDRA_ECOLI pepwindow swissprot:LDRA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LDRA_ECOLI sigcleave swissprot:LDRA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LDRA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260026 4 # EcoGene EG13134 uup # GO_component GO:0005737 cytoplasm; IDA:EcoCyc. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016887 ATPase activity; IDA:EcoCyc. # GO_process GO:0006810 transport; IEA:UniProtKB-KW. # GO_process GO:0070894 regulation of transposon integration; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.300 -; 2. # IntAct P43672 13 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # InterPro IPR032524 ABC_tran_C # InterPro IPR032781 ABC_tran_Xtn # KEGG_Brite ko02000 Transporters # Organism UUP_ECOLI Escherichia coli (strain K12) # PATRIC 32117117 VBIEscCol129921_0983 # PDB 2LW1 NMR; -; A=528-635 # PIR D64835 D64835 # PROSITE PS00211 ABC_TRANSPORTER_1; 2 # PROSITE PS50893 ABC_TRANSPORTER_2; 2 # Pfam PF00005 ABC_tran; 2 # Pfam PF12848 ABC_tran_Xtn # Pfam PF16326 ABC_tran_CTD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UUP_ECOLI ABC transporter ATP-binding protein uup # RefSeq NP_415469 NC_000913.3 # RefSeq WP_000053099 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=X81561; Type=Frameshift; Positions=407, 437, 541, 617; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily. {ECO 0000305}. # SIMILARITY Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA; 2 # SUPFAM SSF52540 SSF52540; 2 # TCDB 3.A.1.120 the atp-binding cassette (abc) superfamily # eggNOG COG0488 LUCA # eggNOG ENOG4105C5H Bacteria BLAST swissprot:UUP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UUP_ECOLI BioCyc ECOL316407:JW0932-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0932-MONOMER BioCyc EcoCyc:UUP-MONOMER http://biocyc.org/getid?id=EcoCyc:UUP-MONOMER COG COG0488 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0488 DIP DIP-11099N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11099N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X81561 http://www.ebi.ac.uk/ena/data/view/X81561 EMBL Y09439 http://www.ebi.ac.uk/ena/data/view/Y09439 EchoBASE EB2933 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2933 EcoGene EG13134 http://www.ecogene.org/geneInfo.php?eg_id=EG13134 EnsemblBacteria AAC74035 http://www.ensemblgenomes.org/id/AAC74035 EnsemblBacteria AAC74035 http://www.ensemblgenomes.org/id/AAC74035 EnsemblBacteria BAA35707 http://www.ensemblgenomes.org/id/BAA35707 EnsemblBacteria BAA35707 http://www.ensemblgenomes.org/id/BAA35707 EnsemblBacteria BAA35707 http://www.ensemblgenomes.org/id/BAA35707 EnsemblBacteria b0949 http://www.ensemblgenomes.org/id/b0949 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GO_process GO:0070894 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070894 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945566 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945566 HOGENOM HOG000271635 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000271635&db=HOGENOM6 InParanoid P43672 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P43672 IntAct P43672 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P43672* InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR032524 http://www.ebi.ac.uk/interpro/entry/IPR032524 InterPro IPR032781 http://www.ebi.ac.uk/interpro/entry/IPR032781 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0932 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0932 KEGG_Gene eco:b0949 http://www.genome.jp/dbget-bin/www_bget?eco:b0949 KEGG_Orthology KO:K15738 http://www.genome.jp/dbget-bin/www_bget?KO:K15738 MINT MINT-1228036 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1228036 OMA RHDEIEM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RHDEIEM PDB 2LW1 http://www.ebi.ac.uk/pdbe-srv/view/entry/2LW1 PDBsum 2LW1 http://www.ebi.ac.uk/pdbsum/2LW1 PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:UUP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UUP_ECOLI PSORT-B swissprot:UUP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UUP_ECOLI PSORT2 swissprot:UUP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UUP_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Pfam PF12848 http://pfam.xfam.org/family/PF12848 Pfam PF16326 http://pfam.xfam.org/family/PF16326 Phobius swissprot:UUP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UUP_ECOLI PhylomeDB P43672 http://phylomedb.org/?seqid=P43672 ProteinModelPortal P43672 http://www.proteinmodelportal.org/query/uniprot/P43672 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7751275 http://www.ncbi.nlm.nih.gov/pubmed/7751275 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9139905 http://www.ncbi.nlm.nih.gov/pubmed/9139905 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415469 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415469 RefSeq WP_000053099 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000053099 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P43672 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P43672 STRING 511145.b0949 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0949&targetmode=cogs STRING COG0488 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0488&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.120 http://www.tcdb.org/search/result.php?tc=3.A.1.120 UniProtKB UUP_ECOLI http://www.uniprot.org/uniprot/UUP_ECOLI UniProtKB-AC P43672 http://www.uniprot.org/uniprot/P43672 charge swissprot:UUP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UUP_ECOLI eggNOG COG0488 http://eggnogapi.embl.de/nog_data/html/tree/COG0488 eggNOG ENOG4105C5H http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C5H epestfind swissprot:UUP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UUP_ECOLI garnier swissprot:UUP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UUP_ECOLI helixturnhelix swissprot:UUP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UUP_ECOLI hmoment swissprot:UUP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UUP_ECOLI iep swissprot:UUP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UUP_ECOLI inforesidue swissprot:UUP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UUP_ECOLI octanol swissprot:UUP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UUP_ECOLI pepcoil swissprot:UUP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UUP_ECOLI pepdigest swissprot:UUP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UUP_ECOLI pepinfo swissprot:UUP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UUP_ECOLI pepnet swissprot:UUP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UUP_ECOLI pepstats swissprot:UUP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UUP_ECOLI pepwheel swissprot:UUP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UUP_ECOLI pepwindow swissprot:UUP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UUP_ECOLI sigcleave swissprot:UUP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UUP_ECOLI ## Database ID URL or Descriptions # AltName STFR_ECOLI Side tail fiber protein homolog from lambdoid prophage Rac # BioGrid 4260171 142 # EcoGene EG13370 stfR # GO_function GO:0005198 structural molecule activity; IEA:InterPro. # GOslim_function GO:0005198 structural molecule activity # Gene3D 2.60.40.1120 -; 1. # Gene3D 3.90.1340.10 -; 1. # IntAct P76072 16 # InterPro IPR005003 Phage_lambda_Stf-r1 # InterPro IPR008969 CarboxyPept-like_regulatory # InterPro IPR011083 Phage_tail_collar_dom # InterPro IPR013609 Phage_933W_L0121_N # InterPro IPR014766 CarboxyPept_regulatory_dom # Organism STFR_ECOLI Escherichia coli (strain K12) # PATRIC 32118026 VBIEscCol129921_1433 # PIR G64887 G64887 # Pfam PF03335 Phage_fiber; 6 # Pfam PF07484 Collar # Pfam PF08400 phage_tail_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Prophage side tail fiber protein homolog StfR {ECO 0000305} # RefSeq NP_415890 NC_000913.3 # SIMILARITY Belongs to the tail fiber family. {ECO 0000305}. # SUPFAM SSF49464 SSF49464 # eggNOG ENOG4108X9F Bacteria # eggNOG ENOG4111PZP LUCA BLAST swissprot:STFR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:STFR_ECOLI BioCyc ECOL316407:JW1366-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1366-MONOMER BioCyc EcoCyc:G6695-MONOMER http://biocyc.org/getid?id=EcoCyc:G6695-MONOMER DIP DIP-10932N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10932N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3152 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3152 EcoGene EG13370 http://www.ecogene.org/geneInfo.php?eg_id=EG13370 EnsemblBacteria AAC74454 http://www.ensemblgenomes.org/id/AAC74454 EnsemblBacteria AAC74454 http://www.ensemblgenomes.org/id/AAC74454 EnsemblBacteria BAA14966 http://www.ensemblgenomes.org/id/BAA14966 EnsemblBacteria BAA14966 http://www.ensemblgenomes.org/id/BAA14966 EnsemblBacteria BAA14966 http://www.ensemblgenomes.org/id/BAA14966 EnsemblBacteria b1372 http://www.ensemblgenomes.org/id/b1372 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005198 GOslim_function GO:0005198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005198 Gene3D 2.60.40.1120 http://www.cathdb.info/version/latest/superfamily/2.60.40.1120 Gene3D 3.90.1340.10 http://www.cathdb.info/version/latest/superfamily/3.90.1340.10 GeneID 945207 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945207 HOGENOM HOG000120054 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120054&db=HOGENOM6 IntAct P76072 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76072* InterPro IPR005003 http://www.ebi.ac.uk/interpro/entry/IPR005003 InterPro IPR008969 http://www.ebi.ac.uk/interpro/entry/IPR008969 InterPro IPR011083 http://www.ebi.ac.uk/interpro/entry/IPR011083 InterPro IPR013609 http://www.ebi.ac.uk/interpro/entry/IPR013609 InterPro IPR014766 http://www.ebi.ac.uk/interpro/entry/IPR014766 KEGG_Gene ecj:JW1366 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1366 KEGG_Gene eco:b1372 http://www.genome.jp/dbget-bin/www_bget?eco:b1372 OMA TECINAR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TECINAR PSORT swissprot:STFR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:STFR_ECOLI PSORT-B swissprot:STFR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:STFR_ECOLI PSORT2 swissprot:STFR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:STFR_ECOLI Pfam PF03335 http://pfam.xfam.org/family/PF03335 Pfam PF07484 http://pfam.xfam.org/family/PF07484 Pfam PF08400 http://pfam.xfam.org/family/PF08400 Phobius swissprot:STFR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:STFR_ECOLI ProteinModelPortal P76072 http://www.proteinmodelportal.org/query/uniprot/P76072 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415890 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415890 SMR P76072 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76072 STRING 511145.b1372 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1372&targetmode=cogs SUPFAM SSF49464 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49464 UniProtKB STFR_ECOLI http://www.uniprot.org/uniprot/STFR_ECOLI UniProtKB-AC P76072 http://www.uniprot.org/uniprot/P76072 charge swissprot:STFR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:STFR_ECOLI eggNOG ENOG4108X9F http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108X9F eggNOG ENOG4111PZP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111PZP epestfind swissprot:STFR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:STFR_ECOLI garnier swissprot:STFR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:STFR_ECOLI helixturnhelix swissprot:STFR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:STFR_ECOLI hmoment swissprot:STFR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:STFR_ECOLI iep swissprot:STFR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:STFR_ECOLI inforesidue swissprot:STFR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:STFR_ECOLI octanol swissprot:STFR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:STFR_ECOLI pepcoil swissprot:STFR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:STFR_ECOLI pepdigest swissprot:STFR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:STFR_ECOLI pepinfo swissprot:STFR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:STFR_ECOLI pepnet swissprot:STFR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:STFR_ECOLI pepstats swissprot:STFR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:STFR_ECOLI pepwheel swissprot:STFR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:STFR_ECOLI pepwindow swissprot:STFR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:STFR_ECOLI sigcleave swissprot:STFR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:STFR_ECOLI ## Database ID URL or Descriptions # FUNCTION REPB_ECOLI This protein is essential for plasmid replication; it is involved in copy control functions. In vitro, binds to the DNA repeat units, BCDD'D'', EFG and HIJ. # GO_component GO:0005727 extrachromosomal circular DNA; IEA:InterPro. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003887 DNA-directed DNA polymerase activity; IEA:InterPro. # GO_process GO:0006270 DNA replication initiation; IEA:InterPro. # GO_process GO:0006276 plasmid maintenance; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0008150 biological_process # Gene3D 1.10.10.10 -; 1. # InterPro IPR000525 Initiator_Rep_prot # InterPro IPR011991 WHTH_DNA-bd_dom # Organism REPB_ECOLI Escherichia coli (strain K12) # PIR I40829 I40829 # Pfam PF01051 Rep_3 # RecName REPB_ECOLI RepFIB replication protein A # RefSeq NP_061412 NC_002483.1 # RefSeq WP_000361610 NZ_CP014273.1 # SEQUENCE CAUTION Sequence=AAB61762.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the initiator RepB protein family. {ECO 0000305}. BLAST swissprot:REPB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:REPB_ECOLI DOI 10.1006/plas.1993.1020 http://dx.doi.org/10.1006/plas.1993.1020 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL L01255 http://www.ebi.ac.uk/ena/data/view/L01255 EMBL L01256 http://www.ebi.ac.uk/ena/data/view/L01256 EMBL M26308 http://www.ebi.ac.uk/ena/data/view/M26308 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005727 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005727 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003887 GO_process GO:0006270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006270 GO_process GO:0006276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006276 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 1263561 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263561 InterPro IPR000525 http://www.ebi.ac.uk/interpro/entry/IPR000525 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 OMA MTLTPNN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MTLTPNN PSORT swissprot:REPB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:REPB_ECOLI PSORT-B swissprot:REPB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:REPB_ECOLI PSORT2 swissprot:REPB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:REPB_ECOLI Pfam PF01051 http://pfam.xfam.org/family/PF01051 Phobius swissprot:REPB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:REPB_ECOLI ProteinModelPortal Q57154 http://www.proteinmodelportal.org/query/uniprot/Q57154 PubMed 2651415 http://www.ncbi.nlm.nih.gov/pubmed/2651415 PubMed 8320218 http://www.ncbi.nlm.nih.gov/pubmed/8320218 PubMed 8356112 http://www.ncbi.nlm.nih.gov/pubmed/8356112 RefSeq NP_061412 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061412 RefSeq WP_000361610 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000361610 SMR Q57154 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q57154 UniProtKB REPB_ECOLI http://www.uniprot.org/uniprot/REPB_ECOLI UniProtKB-AC Q57154 http://www.uniprot.org/uniprot/Q57154 charge swissprot:REPB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:REPB_ECOLI epestfind swissprot:REPB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:REPB_ECOLI garnier swissprot:REPB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:REPB_ECOLI helixturnhelix swissprot:REPB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:REPB_ECOLI hmoment swissprot:REPB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:REPB_ECOLI iep swissprot:REPB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:REPB_ECOLI inforesidue swissprot:REPB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:REPB_ECOLI octanol swissprot:REPB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:REPB_ECOLI pepcoil swissprot:REPB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:REPB_ECOLI pepdigest swissprot:REPB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:REPB_ECOLI pepinfo swissprot:REPB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:REPB_ECOLI pepnet swissprot:REPB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:REPB_ECOLI pepstats swissprot:REPB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:REPB_ECOLI pepwheel swissprot:REPB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:REPB_ECOLI pepwindow swissprot:REPB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:REPB_ECOLI sigcleave swissprot:REPB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:REPB_ECOLI ## Database ID URL or Descriptions # BioGrid 4262727 238 # EcoGene EG12535 lptF # FUNCTION LPTF_ECOLI Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. {ECO 0000269|PubMed 18375759}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IDA:EcoCyc. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IDA:EcoCyc. # GO_function GO:0015437 lipopolysaccharide-transporting ATPase activity; IDA:EcoCyc. # GO_process GO:0015920 lipopolysaccharide transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR005495 LptG/LptF_permease # InterPro IPR030922 LptF # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00320 Lipopolysaccharide export system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism LPTF_ECOLI Escherichia coli (strain K12) # PATRIC 32124095 VBIEscCol129921_4392 # PIR S56487 S56487 # Pfam PF03739 YjgP_YjgQ # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LPTF_ECOLI Lipopolysaccharide export system permease protein LptF # RefSeq NP_418682 NC_000913.3 # RefSeq WP_000584114 NZ_LN832404.1 # SIMILARITY Belongs to the LptF/LptG family. {ECO 0000305}. # SUBCELLULAR LOCATION LPTF_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT Component of the lipopolysaccharide transport and assembly complex. The LptBFG transporter is composed of two ATP- binding proteins (LptB) and two transmembrane proteins (LptF and LptG). {ECO:0000269|PubMed 19500581}. # TCDB 1.B.42.1 the outer membrane lipopolysaccharide export porin (lps-ep) family # TIGRFAMs TIGR04407 LptF_YjgP # eggNOG COG0795 LUCA # eggNOG ENOG4108M8S Bacteria BLAST swissprot:LPTF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LPTF_ECOLI BioCyc ECOL316407:JW4218-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4218-MONOMER BioCyc EcoCyc:G7888-MONOMER http://biocyc.org/getid?id=EcoCyc:G7888-MONOMER BioCyc MetaCyc:G7888-MONOMER http://biocyc.org/getid?id=MetaCyc:G7888-MONOMER COG COG0795 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0795 DOI 10.1016/j.febslet.2009.05.051 http://dx.doi.org/10.1016/j.febslet.2009.05.051 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0801196105 http://dx.doi.org/10.1073/pnas.0801196105 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2424 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2424 EcoGene EG12535 http://www.ecogene.org/geneInfo.php?eg_id=EG12535 EnsemblBacteria AAC77218 http://www.ensemblgenomes.org/id/AAC77218 EnsemblBacteria AAC77218 http://www.ensemblgenomes.org/id/AAC77218 EnsemblBacteria BAE78258 http://www.ensemblgenomes.org/id/BAE78258 EnsemblBacteria BAE78258 http://www.ensemblgenomes.org/id/BAE78258 EnsemblBacteria BAE78258 http://www.ensemblgenomes.org/id/BAE78258 EnsemblBacteria b4261 http://www.ensemblgenomes.org/id/b4261 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0015437 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015437 GO_process GO:0015920 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015920 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948795 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948795 HOGENOM HOG000283246 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000283246&db=HOGENOM6 InParanoid P0AF98 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AF98 IntAct P0AF98 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AF98* InterPro IPR005495 http://www.ebi.ac.uk/interpro/entry/IPR005495 InterPro IPR030922 http://www.ebi.ac.uk/interpro/entry/IPR030922 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW4218 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4218 KEGG_Gene eco:b4261 http://www.genome.jp/dbget-bin/www_bget?eco:b4261 KEGG_Orthology KO:K07091 http://www.genome.jp/dbget-bin/www_bget?KO:K07091 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 MINT MINT-7137013 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-7137013 OMA LGLWWVH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LGLWWVH PSORT swissprot:LPTF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LPTF_ECOLI PSORT-B swissprot:LPTF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LPTF_ECOLI PSORT2 swissprot:LPTF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LPTF_ECOLI Pfam PF03739 http://pfam.xfam.org/family/PF03739 Phobius swissprot:LPTF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LPTF_ECOLI PhylomeDB P0AF98 http://phylomedb.org/?seqid=P0AF98 ProteinModelPortal P0AF98 http://www.proteinmodelportal.org/query/uniprot/P0AF98 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18375759 http://www.ncbi.nlm.nih.gov/pubmed/18375759 PubMed 19500581 http://www.ncbi.nlm.nih.gov/pubmed/19500581 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418682 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418682 RefSeq WP_000584114 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000584114 STRING 511145.b4261 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4261&targetmode=cogs STRING COG0795 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0795&targetmode=cogs TCDB 1.B.42.1 http://www.tcdb.org/search/result.php?tc=1.B.42.1 TIGRFAMs TIGR04407 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR04407 UniProtKB LPTF_ECOLI http://www.uniprot.org/uniprot/LPTF_ECOLI UniProtKB-AC P0AF98 http://www.uniprot.org/uniprot/P0AF98 charge swissprot:LPTF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LPTF_ECOLI eggNOG COG0795 http://eggnogapi.embl.de/nog_data/html/tree/COG0795 eggNOG ENOG4108M8S http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108M8S epestfind swissprot:LPTF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LPTF_ECOLI garnier swissprot:LPTF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LPTF_ECOLI helixturnhelix swissprot:LPTF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LPTF_ECOLI hmoment swissprot:LPTF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LPTF_ECOLI iep swissprot:LPTF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LPTF_ECOLI inforesidue swissprot:LPTF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LPTF_ECOLI octanol swissprot:LPTF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LPTF_ECOLI pepcoil swissprot:LPTF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LPTF_ECOLI pepdigest swissprot:LPTF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LPTF_ECOLI pepinfo swissprot:LPTF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LPTF_ECOLI pepnet swissprot:LPTF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LPTF_ECOLI pepstats swissprot:LPTF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LPTF_ECOLI pepwheel swissprot:LPTF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LPTF_ECOLI pepwindow swissprot:LPTF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LPTF_ECOLI sigcleave swissprot:LPTF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LPTF_ECOLI ## Database ID URL or Descriptions # AltName YNFO_ECOLI Uncharacterized protein YnfO from Qin prophage # BioGrid 4260237 4 # EcoGene EG14422 ynfO # InterPro IPR025030 DUF3950 # Organism YNFO_ECOLI Escherichia coli (strain K12) # PATRIC 32118400 VBIEscCol129921_1620 # Pfam PF13132 DUF3950 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Uncharacterized protein YnfO {ECO 0000305} # RefSeq WP_001368374 NZ_LN832404.1 # RefSeq YP_588454 NC_000913.3 # eggNOG ENOG4106YSC Bacteria # eggNOG ENOG410XYTI LUCA BLAST swissprot:YNFO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNFO_ECOLI BioCyc ECOL316407:JW5251-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5251-MONOMER BioCyc EcoCyc:MONOMER0-2674 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2674 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14422 http://www.ecogene.org/geneInfo.php?eg_id=EG14422 EnsemblBacteria ABD18667 http://www.ensemblgenomes.org/id/ABD18667 EnsemblBacteria ABD18667 http://www.ensemblgenomes.org/id/ABD18667 EnsemblBacteria BAE76465 http://www.ensemblgenomes.org/id/BAE76465 EnsemblBacteria BAE76465 http://www.ensemblgenomes.org/id/BAE76465 EnsemblBacteria BAE76465 http://www.ensemblgenomes.org/id/BAE76465 EnsemblBacteria b4533 http://www.ensemblgenomes.org/id/b4533 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1450267 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1450267 HOGENOM HOG000009884 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009884&db=HOGENOM6 InterPro IPR025030 http://www.ebi.ac.uk/interpro/entry/IPR025030 KEGG_Gene ecj:JW5251 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5251 KEGG_Gene eco:b4533 http://www.genome.jp/dbget-bin/www_bget?eco:b4533 OMA RACTSIQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RACTSIQ PSORT swissprot:YNFO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNFO_ECOLI PSORT-B swissprot:YNFO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNFO_ECOLI PSORT2 swissprot:YNFO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNFO_ECOLI Pfam PF13132 http://pfam.xfam.org/family/PF13132 Phobius swissprot:YNFO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNFO_ECOLI ProteinModelPortal Q2EES0 http://www.proteinmodelportal.org/query/uniprot/Q2EES0 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001368374 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001368374 RefSeq YP_588454 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_588454 STRING 511145.b4533 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4533&targetmode=cogs UniProtKB YNFO_ECOLI http://www.uniprot.org/uniprot/YNFO_ECOLI UniProtKB-AC Q2EES0 http://www.uniprot.org/uniprot/Q2EES0 charge swissprot:YNFO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNFO_ECOLI eggNOG ENOG4106YSC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106YSC eggNOG ENOG410XYTI http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XYTI epestfind swissprot:YNFO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNFO_ECOLI garnier swissprot:YNFO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNFO_ECOLI helixturnhelix swissprot:YNFO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNFO_ECOLI hmoment swissprot:YNFO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNFO_ECOLI iep swissprot:YNFO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNFO_ECOLI inforesidue swissprot:YNFO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNFO_ECOLI octanol swissprot:YNFO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNFO_ECOLI pepcoil swissprot:YNFO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNFO_ECOLI pepdigest swissprot:YNFO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNFO_ECOLI pepinfo swissprot:YNFO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNFO_ECOLI pepnet swissprot:YNFO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNFO_ECOLI pepstats swissprot:YNFO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNFO_ECOLI pepwheel swissprot:YNFO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNFO_ECOLI pepwindow swissprot:YNFO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNFO_ECOLI sigcleave swissprot:YNFO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNFO_ECOLI ## Database ID URL or Descriptions # BioGrid 4262151 10 # EcoGene EG12463 yjdF # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR014509 UCP020606 # Organism YJDF_ECOLI Escherichia coli (strain K12) # PATRIC 32123807 VBIEscCol129921_4252 # PIR S56350 S56350 # PIRSF PIRSF020606 UCP020606 # Pfam PF09997 DUF2238 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJDF_ECOLI Inner membrane protein YjdF # RefSeq NP_418545 NC_000913.3 # RefSeq WP_000198773 NZ_LN832404.1 # SUBCELLULAR LOCATION YJDF_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG COG3647 LUCA # eggNOG ENOG4108R5S Bacteria BLAST swissprot:YJDF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJDF_ECOLI BioCyc ECOL316407:JW4082-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4082-MONOMER BioCyc EcoCyc:G7825-MONOMER http://biocyc.org/getid?id=EcoCyc:G7825-MONOMER COG COG3647 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3647 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M27058 http://www.ebi.ac.uk/ena/data/view/M27058 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2356 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2356 EcoGene EG12463 http://www.ecogene.org/geneInfo.php?eg_id=EG12463 EnsemblBacteria AAC77082 http://www.ensemblgenomes.org/id/AAC77082 EnsemblBacteria AAC77082 http://www.ensemblgenomes.org/id/AAC77082 EnsemblBacteria BAE78123 http://www.ensemblgenomes.org/id/BAE78123 EnsemblBacteria BAE78123 http://www.ensemblgenomes.org/id/BAE78123 EnsemblBacteria BAE78123 http://www.ensemblgenomes.org/id/BAE78123 EnsemblBacteria b4121 http://www.ensemblgenomes.org/id/b4121 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 948634 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948634 HOGENOM HOG000281612 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000281612&db=HOGENOM6 InParanoid P39270 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39270 InterPro IPR014509 http://www.ebi.ac.uk/interpro/entry/IPR014509 KEGG_Gene ecj:JW4082 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4082 KEGG_Gene eco:b4121 http://www.genome.jp/dbget-bin/www_bget?eco:b4121 KEGG_Orthology KO:K08984 http://www.genome.jp/dbget-bin/www_bget?KO:K08984 OMA AYPIAEY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AYPIAEY PSORT swissprot:YJDF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJDF_ECOLI PSORT-B swissprot:YJDF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJDF_ECOLI PSORT2 swissprot:YJDF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJDF_ECOLI Pfam PF09997 http://pfam.xfam.org/family/PF09997 Phobius swissprot:YJDF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJDF_ECOLI PhylomeDB P39270 http://phylomedb.org/?seqid=P39270 ProteinModelPortal P39270 http://www.proteinmodelportal.org/query/uniprot/P39270 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2656658 http://www.ncbi.nlm.nih.gov/pubmed/2656658 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418545 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418545 RefSeq WP_000198773 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000198773 STRING 511145.b4121 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4121&targetmode=cogs STRING COG3647 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3647&targetmode=cogs UniProtKB YJDF_ECOLI http://www.uniprot.org/uniprot/YJDF_ECOLI UniProtKB-AC P39270 http://www.uniprot.org/uniprot/P39270 charge swissprot:YJDF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJDF_ECOLI eggNOG COG3647 http://eggnogapi.embl.de/nog_data/html/tree/COG3647 eggNOG ENOG4108R5S http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108R5S epestfind swissprot:YJDF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJDF_ECOLI garnier swissprot:YJDF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJDF_ECOLI helixturnhelix swissprot:YJDF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJDF_ECOLI hmoment swissprot:YJDF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJDF_ECOLI iep swissprot:YJDF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJDF_ECOLI inforesidue swissprot:YJDF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJDF_ECOLI octanol swissprot:YJDF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJDF_ECOLI pepcoil swissprot:YJDF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJDF_ECOLI pepdigest swissprot:YJDF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJDF_ECOLI pepinfo swissprot:YJDF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJDF_ECOLI pepnet swissprot:YJDF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJDF_ECOLI pepstats swissprot:YJDF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJDF_ECOLI pepwheel swissprot:YJDF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJDF_ECOLI pepwindow swissprot:YJDF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJDF_ECOLI sigcleave swissprot:YJDF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJDF_ECOLI ## Database ID URL or Descriptions # AltName OSMC_ECOLI Osmotically-inducible protein C # BioGrid 4260206 228 # CATALYTIC ACTIVITY OSMC_ECOLI 2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH. # EcoGene EG10680 osmC # FUNCTION OSMC_ECOLI Preferentially metabolizes organic hydroperoxides over inorganic hydrogen peroxide. {ECO 0000269|PubMed 14627744}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004601 peroxidase activity; IDA:EcoCyc. # GO_function GO:0051920 peroxiredoxin activity; IDA:EcoCyc. # GO_process GO:0006972 hyperosmotic response; IEP:EcoCyc. # GO_process GO:0006979 response to oxidative stress; IMP:EcoCyc. # GO_process GO:0033194 response to hydroperoxide; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006950 response to stress # Gene3D 3.30.300.20 -; 1. # INDUCTION OSMC_ECOLI By elevated osmotic pressure in the growth medium. # IntAct P0C0L2 11 # InterPro IPR003718 OsmC/Ohr_fam # InterPro IPR015946 KH_dom-like_a/b # InterPro IPR019904 Peroxiredoxin_OsmC # Organism OSMC_ECOLI Escherichia coli (strain K12) # PATRIC 32118258 VBIEscCol129921_1549 # PDB 1NYE X-ray; 2.40 A; A/B/C/D/E/F=1-143 # PDB 1QWI X-ray; 1.80 A; A/B/C/D=1-143 # PIR E64901 E64901 # Pfam PF02566 OsmC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName OSMC_ECOLI Peroxiredoxin OsmC # RefSeq NP_415999 NC_000913.3 # RefSeq WP_000152305 NZ_LN832404.1 # SIMILARITY Belongs to the OsmC/Ohr family. {ECO 0000305}. # SUBCELLULAR LOCATION OSMC_ECOLI Cytoplasm. # SUPFAM SSF82784 SSF82784 # TIGRFAMs TIGR03562 osmo_induc_OsmC # eggNOG COG1764 LUCA # eggNOG ENOG4108Z9K Bacteria BLAST swissprot:OSMC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:OSMC_ECOLI BioCyc ECOL316407:JW1477-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1477-MONOMER BioCyc EcoCyc:EG10680-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10680-MONOMER BioCyc MetaCyc:EG10680-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10680-MONOMER COG COG1764 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1764 DIP DIP-48058N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48058N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1016/0022-2836(91)90366-E http://dx.doi.org/10.1016/0022-2836(91)90366-E DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1107/S0907444904005013 http://dx.doi.org/10.1107/S0907444904005013 DOI 10.1110/ps.03375603 http://dx.doi.org/10.1110/ps.03375603 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.11.1.15 http://www.genome.jp/dbget-bin/www_bget?EC:1.11.1.15 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X57433 http://www.ebi.ac.uk/ena/data/view/X57433 ENZYME 1.11.1.15 http://enzyme.expasy.org/EC/1.11.1.15 EchoBASE EB0674 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0674 EcoGene EG10680 http://www.ecogene.org/geneInfo.php?eg_id=EG10680 EnsemblBacteria AAC74555 http://www.ensemblgenomes.org/id/AAC74555 EnsemblBacteria AAC74555 http://www.ensemblgenomes.org/id/AAC74555 EnsemblBacteria BAA15128 http://www.ensemblgenomes.org/id/BAA15128 EnsemblBacteria BAA15128 http://www.ensemblgenomes.org/id/BAA15128 EnsemblBacteria BAA15128 http://www.ensemblgenomes.org/id/BAA15128 EnsemblBacteria b1482 http://www.ensemblgenomes.org/id/b1482 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004601 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004601 GO_function GO:0051920 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051920 GO_process GO:0006972 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006972 GO_process GO:0006979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979 GO_process GO:0033194 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033194 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.30.300.20 http://www.cathdb.info/version/latest/superfamily/3.30.300.20 GeneID 946043 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946043 HOGENOM HOG000060052 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000060052&db=HOGENOM6 InParanoid P0C0L2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0C0L2 IntAct P0C0L2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0C0L2* IntEnz 1.11.1.15 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.11.1.15 InterPro IPR003718 http://www.ebi.ac.uk/interpro/entry/IPR003718 InterPro IPR015946 http://www.ebi.ac.uk/interpro/entry/IPR015946 InterPro IPR019904 http://www.ebi.ac.uk/interpro/entry/IPR019904 KEGG_Gene ecj:JW1477 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1477 KEGG_Gene eco:b1482 http://www.genome.jp/dbget-bin/www_bget?eco:b1482 KEGG_Orthology KO:K04063 http://www.genome.jp/dbget-bin/www_bget?KO:K04063 OMA WQGGIKD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WQGGIKD PDB 1NYE http://www.ebi.ac.uk/pdbe-srv/view/entry/1NYE PDB 1QWI http://www.ebi.ac.uk/pdbe-srv/view/entry/1QWI PDBsum 1NYE http://www.ebi.ac.uk/pdbsum/1NYE PDBsum 1QWI http://www.ebi.ac.uk/pdbsum/1QWI PSORT swissprot:OSMC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:OSMC_ECOLI PSORT-B swissprot:OSMC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:OSMC_ECOLI PSORT2 swissprot:OSMC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:OSMC_ECOLI Pfam PF02566 http://pfam.xfam.org/family/PF02566 Phobius swissprot:OSMC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:OSMC_ECOLI PhylomeDB P0C0L2 http://phylomedb.org/?seqid=P0C0L2 ProteinModelPortal P0C0L2 http://www.proteinmodelportal.org/query/uniprot/P0C0L2 PubMed 14627744 http://www.ncbi.nlm.nih.gov/pubmed/14627744 PubMed 15103136 http://www.ncbi.nlm.nih.gov/pubmed/15103136 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1715407 http://www.ncbi.nlm.nih.gov/pubmed/1715407 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_415999 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415999 RefSeq WP_000152305 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000152305 SMR P0C0L2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0C0L2 STRING 511145.b1482 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1482&targetmode=cogs STRING COG1764 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1764&targetmode=cogs SUPFAM SSF82784 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF82784 TIGRFAMs TIGR03562 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03562 UniProtKB OSMC_ECOLI http://www.uniprot.org/uniprot/OSMC_ECOLI UniProtKB-AC P0C0L2 http://www.uniprot.org/uniprot/P0C0L2 charge swissprot:OSMC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:OSMC_ECOLI eggNOG COG1764 http://eggnogapi.embl.de/nog_data/html/tree/COG1764 eggNOG ENOG4108Z9K http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Z9K epestfind swissprot:OSMC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:OSMC_ECOLI garnier swissprot:OSMC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:OSMC_ECOLI helixturnhelix swissprot:OSMC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:OSMC_ECOLI hmoment swissprot:OSMC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:OSMC_ECOLI iep swissprot:OSMC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:OSMC_ECOLI inforesidue swissprot:OSMC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:OSMC_ECOLI octanol swissprot:OSMC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:OSMC_ECOLI pepcoil swissprot:OSMC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:OSMC_ECOLI pepdigest swissprot:OSMC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:OSMC_ECOLI pepinfo swissprot:OSMC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:OSMC_ECOLI pepnet swissprot:OSMC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:OSMC_ECOLI pepstats swissprot:OSMC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:OSMC_ECOLI pepwheel swissprot:OSMC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:OSMC_ECOLI pepwindow swissprot:OSMC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:OSMC_ECOLI sigcleave swissprot:OSMC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:OSMC_ECOLI ## Database ID URL or Descriptions # BioGrid 4261757 3 # EcoGene EG14061 yegR # Organism YEGR_ECOLI Escherichia coli (strain K12) # PATRIC 32119503 VBIEscCol129921_2162 # PIR D64975 D64975 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEGR_ECOLI Uncharacterized protein YegR # RefSeq NP_416589 NC_000913.3 # eggNOG ENOG41076Z6 Bacteria # eggNOG ENOG410Z8AA LUCA BLAST swissprot:YEGR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEGR_ECOLI BioCyc ECOL316407:JW5837-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5837-MONOMER BioCyc EcoCyc:G7122-MONOMER http://biocyc.org/getid?id=EcoCyc:G7122-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3814 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3814 EcoGene EG14061 http://www.ecogene.org/geneInfo.php?eg_id=EG14061 EnsemblBacteria AAC75146 http://www.ensemblgenomes.org/id/AAC75146 EnsemblBacteria AAC75146 http://www.ensemblgenomes.org/id/AAC75146 EnsemblBacteria BAE76582 http://www.ensemblgenomes.org/id/BAE76582 EnsemblBacteria BAE76582 http://www.ensemblgenomes.org/id/BAE76582 EnsemblBacteria BAE76582 http://www.ensemblgenomes.org/id/BAE76582 EnsemblBacteria b2085 http://www.ensemblgenomes.org/id/b2085 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946613 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946613 HOGENOM HOG000122099 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122099&db=HOGENOM6 KEGG_Gene ecj:JW5837 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5837 KEGG_Gene eco:b2085 http://www.genome.jp/dbget-bin/www_bget?eco:b2085 OMA YLNTRAC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YLNTRAC PSORT swissprot:YEGR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEGR_ECOLI PSORT-B swissprot:YEGR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEGR_ECOLI PSORT2 swissprot:YEGR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEGR_ECOLI Phobius swissprot:YEGR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEGR_ECOLI ProteinModelPortal P76406 http://www.proteinmodelportal.org/query/uniprot/P76406 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416589 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416589 STRING 511145.b2085 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2085&targetmode=cogs UniProtKB YEGR_ECOLI http://www.uniprot.org/uniprot/YEGR_ECOLI UniProtKB-AC P76406 http://www.uniprot.org/uniprot/P76406 charge swissprot:YEGR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEGR_ECOLI eggNOG ENOG41076Z6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41076Z6 eggNOG ENOG410Z8AA http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Z8AA epestfind swissprot:YEGR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEGR_ECOLI garnier swissprot:YEGR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEGR_ECOLI helixturnhelix swissprot:YEGR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEGR_ECOLI hmoment swissprot:YEGR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEGR_ECOLI iep swissprot:YEGR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEGR_ECOLI inforesidue swissprot:YEGR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEGR_ECOLI octanol swissprot:YEGR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEGR_ECOLI pepcoil swissprot:YEGR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEGR_ECOLI pepdigest swissprot:YEGR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEGR_ECOLI pepinfo swissprot:YEGR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEGR_ECOLI pepnet swissprot:YEGR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEGR_ECOLI pepstats swissprot:YEGR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEGR_ECOLI pepwheel swissprot:YEGR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEGR_ECOLI pepwindow swissprot:YEGR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEGR_ECOLI sigcleave swissprot:YEGR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEGR_ECOLI ## Database ID URL or Descriptions # BioGrid 4263434 4 # EcoGene EG12821 yhcO # Gene3D 3.30.370.10 -; 1. # IntAct P64616 18 # InterPro IPR000468 Barstar # Organism YHCO_ECOLI Escherichia coli (strain K12) # PATRIC 32121904 VBIEscCol129921_3336 # PIR A65116 A65116 # Pfam PF01337 Barstar # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHCO_ECOLI Uncharacterized protein YhcO # RefSeq NP_417706 NC_000913.3 # RefSeq WP_001029013 NZ_LN832404.1 # SIMILARITY Belongs to the barstar family. {ECO 0000305}. # SUPFAM SSF52038 SSF52038 # eggNOG COG2732 LUCA # eggNOG ENOG4105UNR Bacteria BLAST swissprot:YHCO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHCO_ECOLI BioCyc ECOL316407:JW3208-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3208-MONOMER BioCyc EcoCyc:G7684-MONOMER http://biocyc.org/getid?id=EcoCyc:G7684-MONOMER COG COG2732 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2732 DIP DIP-48199N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48199N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2672 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2672 EcoGene EG12821 http://www.ecogene.org/geneInfo.php?eg_id=EG12821 EnsemblBacteria AAC76271 http://www.ensemblgenomes.org/id/AAC76271 EnsemblBacteria AAC76271 http://www.ensemblgenomes.org/id/AAC76271 EnsemblBacteria BAE77282 http://www.ensemblgenomes.org/id/BAE77282 EnsemblBacteria BAE77282 http://www.ensemblgenomes.org/id/BAE77282 EnsemblBacteria BAE77282 http://www.ensemblgenomes.org/id/BAE77282 EnsemblBacteria b3239 http://www.ensemblgenomes.org/id/b3239 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.30.370.10 http://www.cathdb.info/version/latest/superfamily/3.30.370.10 GeneID 947830 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947830 HOGENOM HOG000125272 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125272&db=HOGENOM6 InParanoid P64616 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P64616 IntAct P64616 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P64616* InterPro IPR000468 http://www.ebi.ac.uk/interpro/entry/IPR000468 KEGG_Gene ecj:JW3208 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3208 KEGG_Gene eco:b3239 http://www.genome.jp/dbget-bin/www_bget?eco:b3239 KEGG_Orthology KO:K03623 http://www.genome.jp/dbget-bin/www_bget?KO:K03623 OMA GQLRFNV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GQLRFNV PSORT swissprot:YHCO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHCO_ECOLI PSORT-B swissprot:YHCO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHCO_ECOLI PSORT2 swissprot:YHCO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHCO_ECOLI Pfam PF01337 http://pfam.xfam.org/family/PF01337 Phobius swissprot:YHCO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHCO_ECOLI ProteinModelPortal P64616 http://www.proteinmodelportal.org/query/uniprot/P64616 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417706 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417706 RefSeq WP_001029013 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001029013 SMR P64616 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P64616 STRING 511145.b3239 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3239&targetmode=cogs STRING COG2732 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2732&targetmode=cogs SUPFAM SSF52038 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52038 UniProtKB YHCO_ECOLI http://www.uniprot.org/uniprot/YHCO_ECOLI UniProtKB-AC P64616 http://www.uniprot.org/uniprot/P64616 charge swissprot:YHCO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHCO_ECOLI eggNOG COG2732 http://eggnogapi.embl.de/nog_data/html/tree/COG2732 eggNOG ENOG4105UNR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105UNR epestfind swissprot:YHCO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHCO_ECOLI garnier swissprot:YHCO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHCO_ECOLI helixturnhelix swissprot:YHCO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHCO_ECOLI hmoment swissprot:YHCO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHCO_ECOLI iep swissprot:YHCO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHCO_ECOLI inforesidue swissprot:YHCO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHCO_ECOLI octanol swissprot:YHCO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHCO_ECOLI pepcoil swissprot:YHCO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHCO_ECOLI pepdigest swissprot:YHCO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHCO_ECOLI pepinfo swissprot:YHCO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHCO_ECOLI pepnet swissprot:YHCO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHCO_ECOLI pepstats swissprot:YHCO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHCO_ECOLI pepwheel swissprot:YHCO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHCO_ECOLI pepwindow swissprot:YHCO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHCO_ECOLI sigcleave swissprot:YHCO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHCO_ECOLI ## Database ID URL or Descriptions # AltName RECN_ECOLI Recombination protein N # BioGrid 4263399 117 # EcoGene EG10831 recN # FUNCTION RECN_ECOLI May be involved in recombinational repair of damaged DNA. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0000724 double-strand break repair via homologous recombination; IDA:EcoCyc. # GO_process GO:0006302 double-strand break repair; IMP:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0009432 SOS response; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # Gene3D 3.40.50.300 -; 3. # INDUCTION Induced by hydroxyurea. {ECO:0000269|PubMed 20005847}. # INTERACTION RECN_ECOLI P76104 ydcP; NbExp=2; IntAct=EBI-548098, EBI-556974; # IntAct P05824 2 # InterPro IPR003395 RecF/RecN/SMC_N # InterPro IPR004604 DNA_recomb/repair_RecN # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko03400 DNA repair and recombination proteins # Organism RECN_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11059 PTHR11059 # PATRIC 32120631 VBIEscCol129921_2714 # PIR C65040 RQECN # PIRSF PIRSF003128 RecN # Pfam PF02463 SMC_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RECN_ECOLI DNA repair protein RecN # RefSeq WP_000880910 NZ_LN832404.1 # RefSeq YP_026172 NC_000913.3 # SIMILARITY Belongs to the RecN family. {ECO 0000305}. # SUBCELLULAR LOCATION RECN_ECOLI Cytoplasm {ECO 0000269|PubMed 21219465}. Note=In 70% of cell localizes to discrete nucleoid foci (probable DNA damage sites) upon treatment with mitomycin C (MMC) for 2 hours. # SUPFAM SSF52540 SSF52540; 3 # TIGRFAMs TIGR00634 recN # eggNOG COG0497 LUCA # eggNOG ENOG4105C4F Bacteria BLAST swissprot:RECN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RECN_ECOLI BioCyc ECOL316407:JW5416-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5416-MONOMER BioCyc EcoCyc:EG10831-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10831-MONOMER COG COG0497 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0497 DIP DIP-10655N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10655N DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/nar/15.13.5041 http://dx.doi.org/10.1093/nar/15.13.5041 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1111/j.1365-2958.2010.07465.x http://dx.doi.org/10.1111/j.1365-2958.2010.07465.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36840 http://www.ebi.ac.uk/ena/data/view/U36840 EMBL Y00357 http://www.ebi.ac.uk/ena/data/view/Y00357 EchoBASE EB0824 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0824 EcoGene EG10831 http://www.ecogene.org/geneInfo.php?eg_id=EG10831 EnsemblBacteria AAT48145 http://www.ensemblgenomes.org/id/AAT48145 EnsemblBacteria AAT48145 http://www.ensemblgenomes.org/id/AAT48145 EnsemblBacteria BAA16501 http://www.ensemblgenomes.org/id/BAA16501 EnsemblBacteria BAA16501 http://www.ensemblgenomes.org/id/BAA16501 EnsemblBacteria BAA16501 http://www.ensemblgenomes.org/id/BAA16501 EnsemblBacteria b2616 http://www.ensemblgenomes.org/id/b2616 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0000724 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000724 GO_process GO:0006302 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006302 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0009432 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009432 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947105 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947105 HOGENOM HOG000009327 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009327&db=HOGENOM6 InParanoid P05824 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P05824 IntAct P05824 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P05824* InterPro IPR003395 http://www.ebi.ac.uk/interpro/entry/IPR003395 InterPro IPR004604 http://www.ebi.ac.uk/interpro/entry/IPR004604 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW5416 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5416 KEGG_Gene eco:b2616 http://www.genome.jp/dbget-bin/www_bget?eco:b2616 KEGG_Orthology KO:K03631 http://www.genome.jp/dbget-bin/www_bget?KO:K03631 MINT MINT-1269449 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1269449 OMA QVICVTH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QVICVTH PANTHER PTHR11059 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11059 PSORT swissprot:RECN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RECN_ECOLI PSORT-B swissprot:RECN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RECN_ECOLI PSORT2 swissprot:RECN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RECN_ECOLI Pfam PF02463 http://pfam.xfam.org/family/PF02463 Phobius swissprot:RECN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RECN_ECOLI PhylomeDB P05824 http://phylomedb.org/?seqid=P05824 ProteinModelPortal P05824 http://www.proteinmodelportal.org/query/uniprot/P05824 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 21219465 http://www.ncbi.nlm.nih.gov/pubmed/21219465 PubMed 3037486 http://www.ncbi.nlm.nih.gov/pubmed/3037486 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000880910 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000880910 RefSeq YP_026172 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026172 SMR P05824 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P05824 STRING 511145.b2616 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2616&targetmode=cogs STRING COG0497 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0497&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR00634 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00634 UniProtKB RECN_ECOLI http://www.uniprot.org/uniprot/RECN_ECOLI UniProtKB-AC P05824 http://www.uniprot.org/uniprot/P05824 charge swissprot:RECN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RECN_ECOLI eggNOG COG0497 http://eggnogapi.embl.de/nog_data/html/tree/COG0497 eggNOG ENOG4105C4F http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C4F epestfind swissprot:RECN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RECN_ECOLI garnier swissprot:RECN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RECN_ECOLI helixturnhelix swissprot:RECN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RECN_ECOLI hmoment swissprot:RECN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RECN_ECOLI iep swissprot:RECN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RECN_ECOLI inforesidue swissprot:RECN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RECN_ECOLI octanol swissprot:RECN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RECN_ECOLI pepcoil swissprot:RECN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RECN_ECOLI pepdigest swissprot:RECN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RECN_ECOLI pepinfo swissprot:RECN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RECN_ECOLI pepnet swissprot:RECN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RECN_ECOLI pepstats swissprot:RECN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RECN_ECOLI pepwheel swissprot:RECN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RECN_ECOLI pepwindow swissprot:RECN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RECN_ECOLI sigcleave swissprot:RECN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RECN_ECOLI ## Database ID URL or Descriptions # AltName FLGI_ECOLI Basal body P-ring protein # BioGrid 4261032 9 # EcoGene EG20265 flgI # FUNCTION FLGI_ECOLI Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation. # GO_component GO:0009428 bacterial-type flagellum basal body, distal rod, P ring; IEA:InterPro. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IEA:InterPro. # GO_function GO:0005198 structural molecule activity; IEA:InterPro. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0071973 bacterial-type flagellum-dependent cell motility; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0005198 structural molecule activity # GOslim_process GO:0006950 response to stress # GOslim_process GO:0048870 cell motility # HAMAP MF_00416 FlgI # IntAct P0A6S3 4 # InterPro IPR001782 Flag_FlgI # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Pathway ko02040 Flagellar assembly # Organism FLGI_ECOLI Escherichia coli (strain K12) # PATRIC 32117401 VBIEscCol129921_1123 # PIR E64851 E64851 # PRINTS PR01010 FLGPRINGFLGI # Pfam PF02119 FlgI # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FLGI_ECOLI Flagellar P-ring protein # RefSeq NP_415598 NC_000913.3 # RefSeq WP_000589326 NZ_LN832404.1 # SIMILARITY Belongs to the FlgI family. {ECO 0000305}. # SUBCELLULAR LOCATION FLGI_ECOLI Periplasm. Bacterial flagellum basal body. # SUBUNIT FLGI_ECOLI The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. # eggNOG COG1706 LUCA # eggNOG ENOG4105D92 Bacteria BLAST swissprot:FLGI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLGI_ECOLI BioCyc ECOL316407:JW1067-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1067-MONOMER BioCyc EcoCyc:FLGI-FLAGELLAR-P-RING http://biocyc.org/getid?id=EcoCyc:FLGI-FLAGELLAR-P-RING COG COG1706 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1706 DIP DIP-47979N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47979N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4162 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4162 EcoGene EG20265 http://www.ecogene.org/geneInfo.php?eg_id=EG20265 EnsemblBacteria AAC74164 http://www.ensemblgenomes.org/id/AAC74164 EnsemblBacteria AAC74164 http://www.ensemblgenomes.org/id/AAC74164 EnsemblBacteria BAA35889 http://www.ensemblgenomes.org/id/BAA35889 EnsemblBacteria BAA35889 http://www.ensemblgenomes.org/id/BAA35889 EnsemblBacteria BAA35889 http://www.ensemblgenomes.org/id/BAA35889 EnsemblBacteria b1080 http://www.ensemblgenomes.org/id/b1080 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009428 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009428 GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0005198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005198 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0071973 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071973 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0005198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005198 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 GeneID 947534 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947534 HAMAP MF_00416 http://hamap.expasy.org/unirule/MF_00416 HOGENOM HOG000265636 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000265636&db=HOGENOM6 InParanoid P0A6S3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6S3 IntAct P0A6S3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6S3* InterPro IPR001782 http://www.ebi.ac.uk/interpro/entry/IPR001782 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW1067 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1067 KEGG_Gene eco:b1080 http://www.genome.jp/dbget-bin/www_bget?eco:b1080 KEGG_Orthology KO:K02394 http://www.genome.jp/dbget-bin/www_bget?KO:K02394 KEGG_Pathway ko02040 http://www.genome.jp/kegg-bin/show_pathway?ko02040 OMA NTQDLDN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NTQDLDN PRINTS PR01010 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01010 PSORT swissprot:FLGI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLGI_ECOLI PSORT-B swissprot:FLGI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLGI_ECOLI PSORT2 swissprot:FLGI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLGI_ECOLI Pfam PF02119 http://pfam.xfam.org/family/PF02119 Phobius swissprot:FLGI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLGI_ECOLI PhylomeDB P0A6S3 http://phylomedb.org/?seqid=P0A6S3 ProteinModelPortal P0A6S3 http://www.proteinmodelportal.org/query/uniprot/P0A6S3 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415598 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415598 RefSeq WP_000589326 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000589326 SMR P0A6S3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6S3 STRING 511145.b1080 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1080&targetmode=cogs STRING COG1706 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1706&targetmode=cogs UniProtKB FLGI_ECOLI http://www.uniprot.org/uniprot/FLGI_ECOLI UniProtKB-AC P0A6S3 http://www.uniprot.org/uniprot/P0A6S3 charge swissprot:FLGI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLGI_ECOLI eggNOG COG1706 http://eggnogapi.embl.de/nog_data/html/tree/COG1706 eggNOG ENOG4105D92 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D92 epestfind swissprot:FLGI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLGI_ECOLI garnier swissprot:FLGI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLGI_ECOLI helixturnhelix swissprot:FLGI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLGI_ECOLI hmoment swissprot:FLGI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLGI_ECOLI iep swissprot:FLGI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLGI_ECOLI inforesidue swissprot:FLGI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLGI_ECOLI octanol swissprot:FLGI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLGI_ECOLI pepcoil swissprot:FLGI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLGI_ECOLI pepdigest swissprot:FLGI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLGI_ECOLI pepinfo swissprot:FLGI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLGI_ECOLI pepnet swissprot:FLGI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLGI_ECOLI pepstats swissprot:FLGI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLGI_ECOLI pepwheel swissprot:FLGI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLGI_ECOLI pepwindow swissprot:FLGI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLGI_ECOLI sigcleave swissprot:FLGI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLGI_ECOLI ## Database ID URL or Descriptions # ALTERNATIVE PRODUCTS TRAI1_ECOLI Event=Alternative initiation; Named isoforms=2; Name=traI; IsoId=P14565-1; Sequence=Displayed; Name=traI*; IsoId=P14565-2; Sequence=VSP_018971; # AltName TRAI1_ECOLI DNA nickase TraI # AltName TRAI1_ECOLI Transesterase TraI # AltName TRAI1_ECOLI Transesterase TraI # CATALYTIC ACTIVITY TRAI1_ECOLI ATP + H(2)O = ADP + phosphate. # CATALYTIC ACTIVITY TRAI1_ECOLI ATP-independent breakage of single-stranded DNA, followed by passage and rejoining. # COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI 18420; # DISRUPTION PHENOTYPE TRAI1_ECOLI Loss of conjugative DNA transfer. {ECO 0000269|PubMed 11054423, ECO 0000269|PubMed 19136009}. # DOMAIN TRAI1_ECOLI Has 4 domains; the relaxase domain (residues 1-330), an unknown domain (residues 330-990), the helicase domain (residues 990-1450) and the C-terminal domain (1450-1756) which is required for conjugative DNA transfer, possibly via interaction with TraM. {ECO 0000269|PubMed 11054423, ECO 0000269|PubMed 15629940}. # ENZYME REGULATION Nicking activity (relaxase) is inhibited by bisphosphonates such as the non-competitive inhibitor imidobisphosphate (PNP), etidronic acid (ETIDRO) and clodronic acid (CLODRO). The latter 2 are competitive inhibitors, and are already used clinically to treat bone loss (marketed as Didronel and Bonefos). All 3 compounds also inhibit conjugation and kill F plasmid-containing cells. They are specific to dual tyrosine relaxases such as those found in F and related R conjugative plasmids. {ECO:0000269|PubMed 17630285}. # FUNCTION TRAI1_ECOLI Conjugative DNA transfer (CDT) is the unidirectional transfer of ssDNA plasmid from a donor to a recipient cell. It is the central mechanism by which antibiotic resistance and virulence factors are propagated in bacterial populations. Part of the relaxosome, which facilitates a site- and strand-specific cut in the origin of transfer by TraI, at the nic site. Relaxosome formation requires binding of IHF and TraY to the oriT region, which then faciliates binding of TraI relaxase. TraI forms a covalent 5'-phosphotyrosine intermediate linkage to the ssDNA. The transesterified T-strand moves from the donor cell to the recipient cell in a 5'to 3' direction, with the DNA helicase activity of TraI unwinding the DNA. DNA transfer occurs via the conjugative pore (transferosome) an intercellular junction mediated by a type IV secretion system, with TraD providing the means to link the relaxosome to the conjugative pore. The relaxase completes DNA transfer by reversing the covalent phosphotyrosine linkage and releasing the T-strand. # FUNCTION TRAI1_ECOLI TraI has also been identified as DNA helicase I. DNA. helicase I is a potent, highly processive DNA-dependent ATPase, able to unwind about 1.1 kb dsDNA per second in a 5' to 3' manner. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003678 DNA helicase activity; IEA:InterPro. # GO_function GO:0003917 DNA topoisomerase type I activity; IEA:UniProtKB-EC. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0000746 conjugation; IEA:UniProtKB-KW. # GO_process GO:0008152 metabolic process; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004386 helicase activity # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.300 -; 1. # InterPro IPR009767 DNA_helicase_TraI # InterPro IPR014059 Conjug_relaxase_N # InterPro IPR014129 Conjug_relaxase_TraI # InterPro IPR014862 TrwC # InterPro IPR027417 P-loop_NTPase # Organism TRAI1_ECOLI Escherichia coli (strain K12) # PDB 1P4D X-ray; 2.60 A; A/B/C=1-330 # PDB 2A0I X-ray; 2.72 A; A=1-330 # PDB 2L8B NMR; -; A=381-569 # PDB 2Q7T X-ray; 2.42 A; A/B=1-300 # PDB 2Q7U X-ray; 3.00 A; A/B=1-300 # PDB 3FLD X-ray; 2.40 A; A/B=1476-1628 # Pfam PF07057 TraI # Pfam PF08751 TrwC # RecName TRAI1_ECOLI DNA helicase I # RecName TRAI1_ECOLI DNA relaxase TraI # RecName TRAI1_ECOLI Multifunctional conjugation protein TraI # RecName TRAI1_ECOLI Multifunctional conjugation protein TraI # RefSeq NP_061483 NC_002483.1. [P14565-1] # RefSeq WP_000987005 NZ_CP014273.1 # SEQUENCE CAUTION Sequence=AAA83930.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY To TraI of plasmid IncFII R100. {ECO 0000305}. # SUBCELLULAR LOCATION TRAI1_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT TRAI1_ECOLI Monomer. Part of the relaxosome, a complex composed of plasmid-encodes TraI, TraM, TraY and host-encoded IHF bound to the F plasmid origin of transfer (oriT). Directly contacts coupling protein TraD. Seems to directly contact TraM via its C-terminus. {ECO 0000269|PubMed 12637015, ECO 0000269|PubMed 14604527, ECO 0000269|PubMed 16984922, ECO 0000269|PubMed 17238924, ECO 0000269|PubMed 17630285}. # SUPFAM SSF52540 SSF52540; 4 # TIGRFAMs TIGR02686 relax_trwC # TIGRFAMs TIGR02760 TraI_TIGR BLAST swissprot:TRAI1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRAI1_ECOLI DOI 10.1016/0022-2836(90)90145-C http://dx.doi.org/10.1016/0022-2836(90)90145-C DOI 10.1016/0378-1119(89)90179-0 http://dx.doi.org/10.1016/0378-1119(89)90179-0 DOI 10.1016/S1570-9639(02)00553-8 http://dx.doi.org/10.1016/S1570-9639(02)00553-8 DOI 10.1016/j.jmb.2008.12.057 http://dx.doi.org/10.1016/j.jmb.2008.12.057 DOI 10.1016/j.str.2003.10.001 http://dx.doi.org/10.1016/j.str.2003.10.001 DOI 10.1016/j.str.2005.06.013 http://dx.doi.org/10.1016/j.str.2005.06.013 DOI 10.1021/bi010877q http://dx.doi.org/10.1021/bi010877q DOI 10.1046/j.1365-2958.1996.5361059.x http://dx.doi.org/10.1046/j.1365-2958.1996.5361059.x DOI 10.1073/pnas.0702760104 http://dx.doi.org/10.1073/pnas.0702760104 DOI 10.1073/pnas.80.15.4659 http://dx.doi.org/10.1073/pnas.80.15.4659 DOI 10.1074/jbc.270.47.28374 http://dx.doi.org/10.1074/jbc.270.47.28374 DOI 10.1074/jbc.270.47.28381 http://dx.doi.org/10.1074/jbc.270.47.28381 DOI 10.1074/jbc.M008728200 http://dx.doi.org/10.1074/jbc.M008728200 DOI 10.1074/jbc.M604412200 http://dx.doi.org/10.1074/jbc.M604412200 DOI 10.1111/j.1365-2958.2006.05576.x http://dx.doi.org/10.1111/j.1365-2958.2006.05576.x DOI 10.1128/JB.187.2.697-706.2005 http://dx.doi.org/10.1128/JB.187.2.697-706.2005 EC_number EC:3.6.4.12 http://www.genome.jp/dbget-bin/www_bget?EC:3.6.4.12 EC_number EC:5.99.1.2 http://www.genome.jp/dbget-bin/www_bget?EC:5.99.1.2 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL M29254 http://www.ebi.ac.uk/ena/data/view/M29254 EMBL M54796 http://www.ebi.ac.uk/ena/data/view/M54796 EMBL M54796 http://www.ebi.ac.uk/ena/data/view/M54796 EMBL U01159 http://www.ebi.ac.uk/ena/data/view/U01159 EMBL U01159 http://www.ebi.ac.uk/ena/data/view/U01159 EMBL X57430 http://www.ebi.ac.uk/ena/data/view/X57430 ENZYME 3.6.4.12 http://enzyme.expasy.org/EC/3.6.4.12 ENZYME 5.99.1.2 http://enzyme.expasy.org/EC/5.99.1.2 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003678 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003678 GO_function GO:0003917 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003917 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0000746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000746 GO_process GO:0008152 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008152 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004386 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 1263574 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263574 IntEnz 3.6.4.12 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.4.12 IntEnz 5.99.1.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.99.1.2 InterPro IPR009767 http://www.ebi.ac.uk/interpro/entry/IPR009767 InterPro IPR014059 http://www.ebi.ac.uk/interpro/entry/IPR014059 InterPro IPR014129 http://www.ebi.ac.uk/interpro/entry/IPR014129 InterPro IPR014862 http://www.ebi.ac.uk/interpro/entry/IPR014862 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 OMA STWETHR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=STWETHR PDB 1P4D http://www.ebi.ac.uk/pdbe-srv/view/entry/1P4D PDB 2A0I http://www.ebi.ac.uk/pdbe-srv/view/entry/2A0I PDB 2L8B http://www.ebi.ac.uk/pdbe-srv/view/entry/2L8B PDB 2Q7T http://www.ebi.ac.uk/pdbe-srv/view/entry/2Q7T PDB 2Q7U http://www.ebi.ac.uk/pdbe-srv/view/entry/2Q7U PDB 3FLD http://www.ebi.ac.uk/pdbe-srv/view/entry/3FLD PDBsum 1P4D http://www.ebi.ac.uk/pdbsum/1P4D PDBsum 2A0I http://www.ebi.ac.uk/pdbsum/2A0I PDBsum 2L8B http://www.ebi.ac.uk/pdbsum/2L8B PDBsum 2Q7T http://www.ebi.ac.uk/pdbsum/2Q7T PDBsum 2Q7U http://www.ebi.ac.uk/pdbsum/2Q7U PDBsum 3FLD http://www.ebi.ac.uk/pdbsum/3FLD PSORT swissprot:TRAI1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRAI1_ECOLI PSORT-B swissprot:TRAI1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRAI1_ECOLI PSORT2 swissprot:TRAI1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRAI1_ECOLI Pfam PF07057 http://pfam.xfam.org/family/PF07057 Pfam PF08751 http://pfam.xfam.org/family/PF08751 Phobius swissprot:TRAI1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRAI1_ECOLI ProteinModelPortal P14565 http://www.proteinmodelportal.org/query/uniprot/P14565 PubMed 11054423 http://www.ncbi.nlm.nih.gov/pubmed/11054423 PubMed 11560509 http://www.ncbi.nlm.nih.gov/pubmed/11560509 PubMed 12637015 http://www.ncbi.nlm.nih.gov/pubmed/12637015 PubMed 14604527 http://www.ncbi.nlm.nih.gov/pubmed/14604527 PubMed 15629940 http://www.ncbi.nlm.nih.gov/pubmed/15629940 PubMed 16216584 http://www.ncbi.nlm.nih.gov/pubmed/16216584 PubMed 16984922 http://www.ncbi.nlm.nih.gov/pubmed/16984922 PubMed 17238924 http://www.ncbi.nlm.nih.gov/pubmed/17238924 PubMed 17630285 http://www.ncbi.nlm.nih.gov/pubmed/17630285 PubMed 19136009 http://www.ncbi.nlm.nih.gov/pubmed/19136009 PubMed 2163400 http://www.ncbi.nlm.nih.gov/pubmed/2163400 PubMed 2164585 http://www.ncbi.nlm.nih.gov/pubmed/2164585 PubMed 2680768 http://www.ncbi.nlm.nih.gov/pubmed/2680768 PubMed 6308637 http://www.ncbi.nlm.nih.gov/pubmed/6308637 PubMed 7499339 http://www.ncbi.nlm.nih.gov/pubmed/7499339 PubMed 7499340 http://www.ncbi.nlm.nih.gov/pubmed/7499340 PubMed 7915817 http://www.ncbi.nlm.nih.gov/pubmed/7915817 PubMed 8386720 http://www.ncbi.nlm.nih.gov/pubmed/8386720 PubMed 8736534 http://www.ncbi.nlm.nih.gov/pubmed/8736534 RefSeq NP_061483 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061483 RefSeq WP_000987005 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000987005 SMR P14565 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P14565 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR02686 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02686 TIGRFAMs TIGR02760 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02760 UniProtKB TRAI1_ECOLI http://www.uniprot.org/uniprot/TRAI1_ECOLI UniProtKB-AC P14565 http://www.uniprot.org/uniprot/P14565 charge swissprot:TRAI1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRAI1_ECOLI epestfind swissprot:TRAI1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRAI1_ECOLI garnier swissprot:TRAI1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRAI1_ECOLI helixturnhelix swissprot:TRAI1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRAI1_ECOLI hmoment swissprot:TRAI1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRAI1_ECOLI iep swissprot:TRAI1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRAI1_ECOLI inforesidue swissprot:TRAI1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRAI1_ECOLI octanol swissprot:TRAI1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRAI1_ECOLI pepcoil swissprot:TRAI1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRAI1_ECOLI pepdigest swissprot:TRAI1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRAI1_ECOLI pepinfo swissprot:TRAI1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRAI1_ECOLI pepnet swissprot:TRAI1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRAI1_ECOLI pepstats swissprot:TRAI1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRAI1_ECOLI pepwheel swissprot:TRAI1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRAI1_ECOLI pepwindow swissprot:TRAI1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRAI1_ECOLI sigcleave swissprot:TRAI1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRAI1_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES GLMM_ECOLI Kinetic parameters KM=0.05 mM for glucosamine-6-P {ECO 0000269|PubMed 10231382, ECO 0000269|PubMed 10671448}; KM=0.08 mM for glucosamine-1,6-diP {ECO 0000269|PubMed 10231382, ECO 0000269|PubMed 10671448}; KM=0.5 mM for glucose-1,6-diP {ECO 0000269|PubMed 10231382, ECO 0000269|PubMed 10671448}; KM=0.65 mM for glucose-1-P {ECO 0000269|PubMed 10231382, ECO 0000269|PubMed 10671448}; KM=0.06 mM for ATP {ECO 0000269|PubMed 10231382, ECO 0000269|PubMed 10671448}; # BioGrid 4263256 205 # CATALYTIC ACTIVITY GLMM_ECOLI Alpha-D-glucosamine 1-phosphate = D- glucosamine 6-phosphate. # CDD cd05802 GlmM # COFACTOR GLMM_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250}; Note=Binds 1 Mg(2+) ion per subunit. {ECO 0000250}; # ENZYME REGULATION Autophosphorylation is inhibited by inorganic phosphate or EDTA. {ECO:0000269|PubMed 10671448}. # EcoGene EG11553 glmM # FUNCTION GLMM_ECOLI Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. Can also catalyze the formation of glucose-6-P from glucose-1-P, although at a 1400-fold lower rate. {ECO 0000269|PubMed 10231382}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008966 phosphoglucosamine mutase activity; IDA:EcoCyc. # GO_process GO:0005975 carbohydrate metabolic process; IEA:InterPro. # GO_process GO:0006048 UDP-N-acetylglucosamine biosynthetic process; IMP:EcoCyc. # GO_process GO:0046777 protein autophosphorylation; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.30.310.50 -; 1. # Gene3D 3.40.120.10 -; 3. # HAMAP MF_01554_B GlmM_B # IntAct P31120 15 # InterPro IPR005841 Alpha-D-phosphohexomutase_SF # InterPro IPR005843 A-D-PHexomutase_C # InterPro IPR005844 A-D-PHexomutase_a/b/a-I # InterPro IPR005845 A-D-PHexomutase_a/b/a-II # InterPro IPR005846 A-D-PHexomutase_a/b/a-III # InterPro IPR006352 GlmM_bact # InterPro IPR016055 A-D-PHexomutase_a/b/a-I/II/III # InterPro IPR016066 A-D-PHexomutase_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00520 Amino sugar and nucleotide sugar metabolism # MISCELLANEOUS GLMM_ECOLI Catalysis proceeds by a classical ping-pong bi-bi reaction mechanism, with alpha-D-glucosamine 1,6-bisphosphate as an intermediate. # Organism GLMM_ECOLI Escherichia coli (strain K12) # PATRIC 32121770 VBIEscCol129921_3269 # PIR I41215 I41215 # PRINTS PR00509 PGMPMM # PROSITE PS00710 PGM_PMM # PTM GLMM_ECOLI Activated by phosphorylation. Can autophosphorylate in vitro using ATP, alpha-D-glucosamine 1,6-bisphosphate or alpha-D-glucose 1,6-bisphosphate. {ECO 0000269|PubMed 10231382, ECO 0000269|PubMed 10671448}. # Pfam PF00408 PGM_PMM_IV # Pfam PF02878 PGM_PMM_I # Pfam PF02879 PGM_PMM_II # Pfam PF02880 PGM_PMM_III # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLMM_ECOLI Phosphoglucosamine mutase # RefSeq NP_417643 NC_000913.3 # RefSeq WP_000071134 NZ_LN832404.1 # SIMILARITY Belongs to the phosphohexose mutase family. {ECO 0000305}. # SUPFAM SSF53738 SSF53738; 3 # SUPFAM SSF55957 SSF55957 # TIGRFAMs TIGR01455 glmM # eggNOG COG1109 LUCA # eggNOG ENOG4107QJF Bacteria BLAST swissprot:GLMM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLMM_ECOLI BioCyc ECOL316407:JW3143-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3143-MONOMER BioCyc EcoCyc:PHOSGLUCOSAMINEMUT-MONOMER http://biocyc.org/getid?id=EcoCyc:PHOSGLUCOSAMINEMUT-MONOMER BioCyc MetaCyc:PHOSGLUCOSAMINEMUT-MONOMER http://biocyc.org/getid?id=MetaCyc:PHOSGLUCOSAMINEMUT-MONOMER COG COG1109 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1109 DIP DIP-10260N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10260N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1432-1327.1999.00373.x http://dx.doi.org/10.1046/j.1432-1327.1999.00373.x DOI 10.1074/jbc.271.1.32 http://dx.doi.org/10.1074/jbc.271.1.32 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.5.1280-1285.2000 http://dx.doi.org/10.1128/JB.182.5.1280-1285.2000 EC_number EC:5.4.2.10 http://www.genome.jp/dbget-bin/www_bget?EC:5.4.2.10 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L12968 http://www.ebi.ac.uk/ena/data/view/L12968 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U01376 http://www.ebi.ac.uk/ena/data/view/U01376 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 5.4.2.10 http://enzyme.expasy.org/EC/5.4.2.10 EchoBASE EB1514 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1514 EcoGene EG11553 http://www.ecogene.org/geneInfo.php?eg_id=EG11553 EnsemblBacteria AAC76208 http://www.ensemblgenomes.org/id/AAC76208 EnsemblBacteria AAC76208 http://www.ensemblgenomes.org/id/AAC76208 EnsemblBacteria BAE77220 http://www.ensemblgenomes.org/id/BAE77220 EnsemblBacteria BAE77220 http://www.ensemblgenomes.org/id/BAE77220 EnsemblBacteria BAE77220 http://www.ensemblgenomes.org/id/BAE77220 EnsemblBacteria b3176 http://www.ensemblgenomes.org/id/b3176 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0008966 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008966 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GO_process GO:0006048 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006048 GO_process GO:0046777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046777 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.30.310.50 http://www.cathdb.info/version/latest/superfamily/3.30.310.50 Gene3D 3.40.120.10 http://www.cathdb.info/version/latest/superfamily/3.40.120.10 GeneID 947692 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947692 HAMAP MF_01554_B http://hamap.expasy.org/unirule/MF_01554_B HOGENOM HOG000268678 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000268678&db=HOGENOM6 InParanoid P31120 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31120 IntAct P31120 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31120* IntEnz 5.4.2.10 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.4.2.10 InterPro IPR005841 http://www.ebi.ac.uk/interpro/entry/IPR005841 InterPro IPR005843 http://www.ebi.ac.uk/interpro/entry/IPR005843 InterPro IPR005844 http://www.ebi.ac.uk/interpro/entry/IPR005844 InterPro IPR005845 http://www.ebi.ac.uk/interpro/entry/IPR005845 InterPro IPR005846 http://www.ebi.ac.uk/interpro/entry/IPR005846 InterPro IPR006352 http://www.ebi.ac.uk/interpro/entry/IPR006352 InterPro IPR016055 http://www.ebi.ac.uk/interpro/entry/IPR016055 InterPro IPR016066 http://www.ebi.ac.uk/interpro/entry/IPR016066 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3143 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3143 KEGG_Gene eco:b3176 http://www.genome.jp/dbget-bin/www_bget?eco:b3176 KEGG_Orthology KO:K03431 http://www.genome.jp/dbget-bin/www_bget?KO:K03431 KEGG_Pathway ko00520 http://www.genome.jp/kegg-bin/show_pathway?ko00520 KEGG_Reaction rn:R02060 http://www.genome.jp/dbget-bin/www_bget?rn:R02060 OMA NSHCDGR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NSHCDGR PRINTS PR00509 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00509 PROSITE PS00710 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00710 PSORT swissprot:GLMM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLMM_ECOLI PSORT-B swissprot:GLMM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLMM_ECOLI PSORT2 swissprot:GLMM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLMM_ECOLI Pfam PF00408 http://pfam.xfam.org/family/PF00408 Pfam PF02878 http://pfam.xfam.org/family/PF02878 Pfam PF02879 http://pfam.xfam.org/family/PF02879 Pfam PF02880 http://pfam.xfam.org/family/PF02880 Phobius swissprot:GLMM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLMM_ECOLI PhylomeDB P31120 http://phylomedb.org/?seqid=P31120 ProteinModelPortal P31120 http://www.proteinmodelportal.org/query/uniprot/P31120 PubMed 10231382 http://www.ncbi.nlm.nih.gov/pubmed/10231382 PubMed 10671448 http://www.ncbi.nlm.nih.gov/pubmed/10671448 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8244950 http://www.ncbi.nlm.nih.gov/pubmed/8244950 PubMed 8550580 http://www.ncbi.nlm.nih.gov/pubmed/8550580 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417643 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417643 RefSeq WP_000071134 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000071134 SMR P31120 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31120 STRING 511145.b3176 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3176&targetmode=cogs STRING COG1109 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1109&targetmode=cogs SUPFAM SSF53738 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53738 SUPFAM SSF55957 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55957 TIGRFAMs TIGR01455 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01455 UniProtKB GLMM_ECOLI http://www.uniprot.org/uniprot/GLMM_ECOLI UniProtKB-AC P31120 http://www.uniprot.org/uniprot/P31120 charge swissprot:GLMM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLMM_ECOLI eggNOG COG1109 http://eggnogapi.embl.de/nog_data/html/tree/COG1109 eggNOG ENOG4107QJF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QJF epestfind swissprot:GLMM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLMM_ECOLI garnier swissprot:GLMM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLMM_ECOLI helixturnhelix swissprot:GLMM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLMM_ECOLI hmoment swissprot:GLMM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLMM_ECOLI iep swissprot:GLMM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLMM_ECOLI inforesidue swissprot:GLMM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLMM_ECOLI octanol swissprot:GLMM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLMM_ECOLI pepcoil swissprot:GLMM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLMM_ECOLI pepdigest swissprot:GLMM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLMM_ECOLI pepinfo swissprot:GLMM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLMM_ECOLI pepnet swissprot:GLMM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLMM_ECOLI pepstats swissprot:GLMM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLMM_ECOLI pepwheel swissprot:GLMM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLMM_ECOLI pepwindow swissprot:GLMM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLMM_ECOLI sigcleave swissprot:GLMM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLMM_ECOLI ## Database ID URL or Descriptions # BioGrid 4262357 2 # EcoGene EG12443 yggL # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # IntAct P38521 13 # InterPro IPR007416 DUF469 # Organism YGGL_ECOLI Escherichia coli (strain K12) # PATRIC 32121332 VBIEscCol129921_3054 # PIR F65081 F65081 # Pfam PF04320 DUF469 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGGL_ECOLI Uncharacterized protein YggL # RefSeq NP_417434 NC_000913.3 # RefSeq WP_001107564 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA69126.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY To H.influenzae HI_0341. {ECO 0000305}. # eggNOG COG3171 LUCA # eggNOG ENOG41090ED Bacteria BLAST swissprot:YGGL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGGL_ECOLI BioCyc ECOL316407:JW2926-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2926-MONOMER BioCyc EcoCyc:EG12443-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12443-MONOMER COG COG3171 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3171 DIP DIP-12189N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12189N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M59471 http://www.ebi.ac.uk/ena/data/view/M59471 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2337 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2337 EcoGene EG12443 http://www.ecogene.org/geneInfo.php?eg_id=EG12443 EnsemblBacteria AAC75996 http://www.ensemblgenomes.org/id/AAC75996 EnsemblBacteria AAC75996 http://www.ensemblgenomes.org/id/AAC75996 EnsemblBacteria BAE77022 http://www.ensemblgenomes.org/id/BAE77022 EnsemblBacteria BAE77022 http://www.ensemblgenomes.org/id/BAE77022 EnsemblBacteria BAE77022 http://www.ensemblgenomes.org/id/BAE77022 EnsemblBacteria b2959 http://www.ensemblgenomes.org/id/b2959 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GeneID 947449 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947449 HOGENOM HOG000262794 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000262794&db=HOGENOM6 InParanoid P38521 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P38521 IntAct P38521 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P38521* InterPro IPR007416 http://www.ebi.ac.uk/interpro/entry/IPR007416 KEGG_Gene ecj:JW2926 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2926 KEGG_Gene eco:b2959 http://www.genome.jp/dbget-bin/www_bget?eco:b2959 KEGG_Orthology KO:K09923 http://www.genome.jp/dbget-bin/www_bget?KO:K09923 OMA WQFAEGT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WQFAEGT PSORT swissprot:YGGL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGGL_ECOLI PSORT-B swissprot:YGGL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGGL_ECOLI PSORT2 swissprot:YGGL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGGL_ECOLI Pfam PF04320 http://pfam.xfam.org/family/PF04320 Phobius swissprot:YGGL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGGL_ECOLI ProteinModelPortal P38521 http://www.proteinmodelportal.org/query/uniprot/P38521 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2001994 http://www.ncbi.nlm.nih.gov/pubmed/2001994 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417434 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417434 RefSeq WP_001107564 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001107564 STRING 511145.b2959 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2959&targetmode=cogs STRING COG3171 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3171&targetmode=cogs UniProtKB YGGL_ECOLI http://www.uniprot.org/uniprot/YGGL_ECOLI UniProtKB-AC P38521 http://www.uniprot.org/uniprot/P38521 charge swissprot:YGGL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGGL_ECOLI eggNOG COG3171 http://eggnogapi.embl.de/nog_data/html/tree/COG3171 eggNOG ENOG41090ED http://eggnogapi.embl.de/nog_data/html/tree/ENOG41090ED epestfind swissprot:YGGL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGGL_ECOLI garnier swissprot:YGGL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGGL_ECOLI helixturnhelix swissprot:YGGL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGGL_ECOLI hmoment swissprot:YGGL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGGL_ECOLI iep swissprot:YGGL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGGL_ECOLI inforesidue swissprot:YGGL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGGL_ECOLI octanol swissprot:YGGL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGGL_ECOLI pepcoil swissprot:YGGL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGGL_ECOLI pepdigest swissprot:YGGL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGGL_ECOLI pepinfo swissprot:YGGL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGGL_ECOLI pepnet swissprot:YGGL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGGL_ECOLI pepstats swissprot:YGGL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGGL_ECOLI pepwheel swissprot:YGGL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGGL_ECOLI pepwindow swissprot:YGGL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGGL_ECOLI sigcleave swissprot:YGGL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGGL_ECOLI ## Database ID URL or Descriptions # CDD cd00495 Ribosomal_L25_TL5_CTC # EcoGene EG10885 rplY # FUNCTION RL25_ECOLI This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Binds to the 5S rRNA independently of L5 and L18. Not required for binding of the 5S rRNA/L5/L18 subcomplex to 23S rRNA. {ECO 0000269|PubMed 3298242, ECO 0000269|PubMed 354687, ECO 0000269|PubMed 8925931}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0022625 cytosolic large ribosomal subunit; IDA:EcoCyc. # GO_function GO:0003735 structural constituent of ribosome; IEA:InterPro. # GO_function GO:0008097 5S rRNA binding; IDA:EcoCyc. # GO_process GO:0006412 translation; IMP:EcoCyc. # GO_process GO:0017148 negative regulation of translation; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_function GO:0019843 rRNA binding # GOslim_process GO:0006412 translation # GOslim_process GO:0008150 biological_process # Gene3D 2.40.240.10 -; 1. # HAMAP MF_01336 Ribosomal_L25 # IntAct P68919 13 # InterPro IPR011035 Ribosomal_L25/Gln-tRNA_synth # InterPro IPR020055 Ribosomal_L25_short # InterPro IPR020056 Rbsml_L25/Gln-tRNA_synth_b-brl # InterPro IPR029751 Ribosomal_L25 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=10693.4; Method=MALDI; Range=1-94; Evidence={ECO:0000269|PubMed 10094780}; # Organism RL25_ECOLI Escherichia coli (strain K12) # PATRIC 32119725 VBIEscCol129921_2273 # PDB 1B75 NMR; -; A=1-94 # PDB 1D6K NMR; -; A=1-94 # PDB 1DFU X-ray; 1.80 A; P=1-94 # PDB 1ML5 EM; 14.00 A; v=1-94 # PDB 2J28 EM; 8.00 A; V=1-94 # PDB 2RDO EM; 9.10 A; V=1-94 # PDB 3BBX EM; 10.00 A; V=1-94 # PDB 3J5L EM; 6.60 A; V=1-94 # PDB 3J7Z EM; 3.90 A; V=1-94 # PDB 3J8G EM; 5.00 A; W=1-94 # PDB 3J9Y EM; 3.90 A; V=1-94 # PDB 3J9Z EM; 3.60 A; LT=1-94 # PDB 3JA1 EM; 3.60 A; LX=1-94 # PDB 3JBU EM; 3.64 A; w=1-94 # PDB 3JBV EM; 3.32 A; w=1-94 # PDB 3JCD EM; 3.70 A; V=1-94 # PDB 3JCE EM; 3.20 A; V=1-94 # PDB 3JCJ EM; 3.70 A; U=1-94 # PDB 3JCN EM; 4.60 A; V=1-94 # PDB 487D EM; 7.50 A; N=1-94 # PDB 4CSU EM; 5.50 A; W=1-94 # PDB 4U1U X-ray; 2.95 A; BV/DV=1-94 # PDB 4U1V X-ray; 3.00 A; BV/DV=1-94 # PDB 4U20 X-ray; 2.90 A; BV/DV=1-94 # PDB 4U24 X-ray; 2.90 A; BV/DV=1-94 # PDB 4U25 X-ray; 2.90 A; BV/DV=1-94 # PDB 4U26 X-ray; 2.80 A; BV/DV=1-94 # PDB 4U27 X-ray; 2.80 A; BV/DV=1-94 # PDB 4UY8 EM; 3.80 A; 8=1-94 # PDB 4V47 EM; 12.30 A; AT=1-94 # PDB 4V48 EM; 11.50 A; AT=1-94 # PDB 4V4H X-ray; 3.46 A; BV/DV=1-94 # PDB 4V4Q X-ray; 3.46 A; BV/DV=1-94 # PDB 4V4V EM; 15.00 A; BT=1-94 # PDB 4V4W EM; 15.00 A; BT=1-94 # PDB 4V50 X-ray; 3.22 A; BV/DV=1-94 # PDB 4V52 X-ray; 3.21 A; BV/DV=1-94 # PDB 4V53 X-ray; 3.54 A; BV/DV=1-94 # PDB 4V54 X-ray; 3.30 A; BV/DV=1-94 # PDB 4V55 X-ray; 4.00 A; BV/DV=1-94 # PDB 4V56 X-ray; 3.93 A; BV/DV=1-94 # PDB 4V57 X-ray; 3.50 A; BV/DV=1-94 # PDB 4V5B X-ray; 3.74 A; AV/CV=1-94 # PDB 4V5H EM; 5.80 A; BW=1-94 # PDB 4V5Y X-ray; 4.45 A; BV/DV=1-94 # PDB 4V64 X-ray; 3.50 A; BV/DV=1-94 # PDB 4V65 EM; 9.00 A; BC=1-94 # PDB 4V66 EM; 9.00 A; BC=1-94 # PDB 4V69 EM; 6.70 A; BV=1-94 # PDB 4V6C X-ray; 3.19 A; BV/DV=1-94 # PDB 4V6D X-ray; 3.81 A; BV/DV=1-94 # PDB 4V6E X-ray; 3.71 A; BV/DV=1-94 # PDB 4V6K EM; 8.25 A; AW=1-94 # PDB 4V6L EM; 13.20 A; BW=1-94 # PDB 4V6M EM; 7.10 A; BV=1-94 # PDB 4V6N EM; 12.10 A; AX=1-94 # PDB 4V6O EM; 14.70 A; BX=1-94 # PDB 4V6P EM; 13.50 A; BX=1-94 # PDB 4V6Q EM; 11.50 A; BX=1-94 # PDB 4V6R EM; 11.50 A; BX=1-94 # PDB 4V6S EM; 13.10 A; AX=1-94 # PDB 4V6T EM; 8.30 A; BV=1-94 # PDB 4V6V EM; 9.80 A; BZ=1-94 # PDB 4V6Y EM; 12.00 A; BV=1-94 # PDB 4V6Z EM; 12.00 A; BV=1-94 # PDB 4V70 EM; 17.00 A; BV=1-94 # PDB 4V71 EM; 20.00 A; BV=1-94 # PDB 4V72 EM; 13.00 A; BV=1-94 # PDB 4V73 EM; 15.00 A; BV=1-94 # PDB 4V74 EM; 17.00 A; BV=1-94 # PDB 4V75 EM; 12.00 A; BV=1-94 # PDB 4V76 EM; 17.00 A; BV=1-94 # PDB 4V77 EM; 17.00 A; BV=1-94 # PDB 4V78 EM; 20.00 A; BV=1-94 # PDB 4V79 EM; 15.00 A; BV=1-94 # PDB 4V7A EM; 9.00 A; BV=1-94 # PDB 4V7B EM; 6.80 A; BV=1-94 # PDB 4V7C EM; 7.60 A; BX=1-94 # PDB 4V7D EM; 7.60 A; AY=1-94 # PDB 4V7I EM; 9.60 A; AV=1-94 # PDB 4V7S X-ray; 3.25 A; BV/DV=1-94 # PDB 4V7T X-ray; 3.19 A; BV/DV=1-94 # PDB 4V7U X-ray; 3.10 A; BV/DV=1-94 # PDB 4V7V X-ray; 3.29 A; BV/DV=1-94 # PDB 4V85 X-ray; 3.20 A; Z=1-94 # PDB 4V89 X-ray; 3.70 A; BZ=1-94 # PDB 4V9C X-ray; 3.30 A; BV/DV=1-94 # PDB 4V9D X-ray; 3.00 A; CV/DV=1-94 # PDB 4V9O X-ray; 2.90 A; AV/CV/EV/GV=1-94 # PDB 4V9P X-ray; 2.90 A; AV/CV/EV/GV=1-94 # PDB 4WF1 X-ray; 3.09 A; BV/DV=1-94 # PDB 4WOI X-ray; 3.00 A; BV/CV=1-94 # PDB 4WWW X-ray; 3.10 A; RV/YV=1-94 # PDB 4YBB X-ray; 2.10 A; CW/DW=1-94 # PDB 5ADY EM; 4.50 A; V=1-94 # PDB 5AFI EM; 2.90 A; V=1-94 # PDB 5AKA EM; 5.70 A; V=1-94 # PDB 5GAD EM; 3.70 A; W=1-94 # PDB 5GAE EM; 3.33 A; W=1-94 # PDB 5GAF EM; 4.30 A; W=1-94 # PDB 5GAG EM; 3.80 A; W=1-94 # PDB 5GAH EM; 3.80 A; W=1-94 # PDB 5IQR EM; 3.00 A; V=1-94 # PDB 5IT8 X-ray; 3.12 A; CW/DW=1-94 # PDB 5J5B X-ray; 2.80 A; CW/DW=1-94 # PDB 5J7L X-ray; 3.00 A; CW/DW=1-94 # PDB 5J88 X-ray; 3.32 A; CW/DW=1-94 # PDB 5J8A X-ray; 3.10 A; CW/DW=1-94 # PDB 5J91 X-ray; 2.96 A; CW/DW=1-94 # PDB 5JC9 X-ray; 3.03 A; CW/DW=1-94 # PDB 5JTE EM; 3.60 A; BV=1-94 # PDB 5JU8 EM; 3.60 A; BV=1-94 # PDB 5KCR EM; 3.60 A; 1Z=1-94 # PDB 5KCS EM; 3.90 A; 1Z=1-94 # PDB 5KPS EM; 3.90 A; V=1-94 # PDB 5KPV EM; 4.10 A; U=1-94 # PDB 5KPW EM; 3.90 A; U=1-94 # PDB 5KPX EM; 3.90 A; U=1-94 # PDB 5L3P EM; 3.70 A; Z=1-94 # PIR S16002 R5EC25 # Pfam PF01386 Ribosomal_L25p # ProDom PD012503 Ribosomal_L25 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RL25_ECOLI 50S ribosomal protein L25 # RefSeq NP_416690 NC_000913.3 # RefSeq WP_000494183 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein L25P family. {ECO 0000305}. # SUBUNIT RL25_ECOLI Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. {ECO 0000269|PubMed 10562563, ECO 0000269|PubMed 10696113, ECO 0000269|PubMed 3298242, ECO 0000269|PubMed 354687, ECO 0000269|PubMed 8925931, ECO 0000269|PubMed 9799245}. # SUPFAM SSF50715 SSF50715 # eggNOG COG1825 LUCA # eggNOG ENOG4105KW6 Bacteria BLAST swissprot:RL25_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RL25_ECOLI BioCyc ECOL316407:JW2173-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2173-MONOMER BioCyc EcoCyc:EG10885-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10885-MONOMER BioCyc MetaCyc:EG10885-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10885-MONOMER COG COG1825 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1825 DIP DIP-35885N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35885N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1006/jmbi.2000.3635 http://dx.doi.org/10.1006/jmbi.2000.3635 DOI 10.1007/BF00273625 http://dx.doi.org/10.1007/BF00273625 DOI 10.1016/0014-5793(75)80053-6 http://dx.doi.org/10.1016/0014-5793(75)80053-6 DOI 10.1016/0014-5793(96)00872-1 http://dx.doi.org/10.1016/0014-5793(96)00872-1 DOI 10.1016/S0092-8674(03)00427-6 http://dx.doi.org/10.1016/S0092-8674(03)00427-6 DOI 10.1016/j.celrep.2014.09.011 http://dx.doi.org/10.1016/j.celrep.2014.09.011 DOI 10.1021/bi00606a002 http://dx.doi.org/10.1021/bi00606a002 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.97.5.2023 http://dx.doi.org/10.1073/pnas.97.5.2023 DOI 10.1093/emboj/17.21.6377 http://dx.doi.org/10.1093/emboj/17.21.6377 DOI 10.1093/emboj/18.22.6508 http://dx.doi.org/10.1093/emboj/18.22.6508 DOI 10.1111/j.1574-6968.1998.tb13343.x http://dx.doi.org/10.1111/j.1574-6968.1998.tb13343.x DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pbio.1001866 http://dx.doi.org/10.1371/journal.pbio.1001866 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D13326 http://www.ebi.ac.uk/ena/data/view/D13326 EMBL U00008 http://www.ebi.ac.uk/ena/data/view/U00008 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0878 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0878 EcoGene EG10885 http://www.ecogene.org/geneInfo.php?eg_id=EG10885 EnsemblBacteria AAC75246 http://www.ensemblgenomes.org/id/AAC75246 EnsemblBacteria AAC75246 http://www.ensemblgenomes.org/id/AAC75246 EnsemblBacteria BAE76650 http://www.ensemblgenomes.org/id/BAE76650 EnsemblBacteria BAE76650 http://www.ensemblgenomes.org/id/BAE76650 EnsemblBacteria BAE76650 http://www.ensemblgenomes.org/id/BAE76650 EnsemblBacteria b2185 http://www.ensemblgenomes.org/id/b2185 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0022625 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022625 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_function GO:0008097 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008097 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GO_process GO:0017148 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017148 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 2.40.240.10 http://www.cathdb.info/version/latest/superfamily/2.40.240.10 GeneID 945618 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945618 HAMAP MF_01336 http://hamap.expasy.org/unirule/MF_01336 HOGENOM HOG000277629 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000277629&db=HOGENOM6 IntAct P68919 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P68919* InterPro IPR011035 http://www.ebi.ac.uk/interpro/entry/IPR011035 InterPro IPR020055 http://www.ebi.ac.uk/interpro/entry/IPR020055 InterPro IPR020056 http://www.ebi.ac.uk/interpro/entry/IPR020056 InterPro IPR029751 http://www.ebi.ac.uk/interpro/entry/IPR029751 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW2173 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2173 KEGG_Gene eco:b2185 http://www.genome.jp/dbget-bin/www_bget?eco:b2185 KEGG_Orthology KO:K02897 http://www.genome.jp/dbget-bin/www_bget?KO:K02897 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 MINT MINT-1261165 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1261165 OMA HAGKFPA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HAGKFPA PDB 1B75 http://www.ebi.ac.uk/pdbe-srv/view/entry/1B75 PDB 1D6K http://www.ebi.ac.uk/pdbe-srv/view/entry/1D6K PDB 1DFU http://www.ebi.ac.uk/pdbe-srv/view/entry/1DFU PDB 1ML5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ML5 PDB 2J28 http://www.ebi.ac.uk/pdbe-srv/view/entry/2J28 PDB 2RDO http://www.ebi.ac.uk/pdbe-srv/view/entry/2RDO PDB 3BBX http://www.ebi.ac.uk/pdbe-srv/view/entry/3BBX PDB 3J5L http://www.ebi.ac.uk/pdbe-srv/view/entry/3J5L PDB 3J7Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J7Z PDB 3J8G http://www.ebi.ac.uk/pdbe-srv/view/entry/3J8G PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 487D http://www.ebi.ac.uk/pdbe-srv/view/entry/487D PDB 4CSU http://www.ebi.ac.uk/pdbe-srv/view/entry/4CSU PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4UY8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4UY8 PDB 4V47 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V47 PDB 4V48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V48 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5ADY http://www.ebi.ac.uk/pdbe-srv/view/entry/5ADY PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5AKA http://www.ebi.ac.uk/pdbe-srv/view/entry/5AKA PDB 5GAD http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAD PDB 5GAE http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAE PDB 5GAF http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAF PDB 5GAG http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAG PDB 5GAH http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAH PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 1B75 http://www.ebi.ac.uk/pdbsum/1B75 PDBsum 1D6K http://www.ebi.ac.uk/pdbsum/1D6K PDBsum 1DFU http://www.ebi.ac.uk/pdbsum/1DFU PDBsum 1ML5 http://www.ebi.ac.uk/pdbsum/1ML5 PDBsum 2J28 http://www.ebi.ac.uk/pdbsum/2J28 PDBsum 2RDO http://www.ebi.ac.uk/pdbsum/2RDO PDBsum 3BBX http://www.ebi.ac.uk/pdbsum/3BBX PDBsum 3J5L http://www.ebi.ac.uk/pdbsum/3J5L PDBsum 3J7Z http://www.ebi.ac.uk/pdbsum/3J7Z PDBsum 3J8G http://www.ebi.ac.uk/pdbsum/3J8G PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 487D http://www.ebi.ac.uk/pdbsum/487D PDBsum 4CSU http://www.ebi.ac.uk/pdbsum/4CSU PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4UY8 http://www.ebi.ac.uk/pdbsum/4UY8 PDBsum 4V47 http://www.ebi.ac.uk/pdbsum/4V47 PDBsum 4V48 http://www.ebi.ac.uk/pdbsum/4V48 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5ADY http://www.ebi.ac.uk/pdbsum/5ADY PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5AKA http://www.ebi.ac.uk/pdbsum/5AKA PDBsum 5GAD http://www.ebi.ac.uk/pdbsum/5GAD PDBsum 5GAE http://www.ebi.ac.uk/pdbsum/5GAE PDBsum 5GAF http://www.ebi.ac.uk/pdbsum/5GAF PDBsum 5GAG http://www.ebi.ac.uk/pdbsum/5GAG PDBsum 5GAH http://www.ebi.ac.uk/pdbsum/5GAH PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PSORT swissprot:RL25_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RL25_ECOLI PSORT-B swissprot:RL25_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RL25_ECOLI PSORT2 swissprot:RL25_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RL25_ECOLI Pfam PF01386 http://pfam.xfam.org/family/PF01386 Phobius swissprot:RL25_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RL25_ECOLI PhylomeDB P68919 http://phylomedb.org/?seqid=P68919 ProteinModelPortal P68919 http://www.proteinmodelportal.org/query/uniprot/P68919 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 10562563 http://www.ncbi.nlm.nih.gov/pubmed/10562563 PubMed 10696113 http://www.ncbi.nlm.nih.gov/pubmed/10696113 PubMed 10756104 http://www.ncbi.nlm.nih.gov/pubmed/10756104 PubMed 1093874 http://www.ncbi.nlm.nih.gov/pubmed/1093874 PubMed 1100506 http://www.ncbi.nlm.nih.gov/pubmed/1100506 PubMed 12809609 http://www.ncbi.nlm.nih.gov/pubmed/12809609 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2034228 http://www.ncbi.nlm.nih.gov/pubmed/2034228 PubMed 24844575 http://www.ncbi.nlm.nih.gov/pubmed/24844575 PubMed 25310980 http://www.ncbi.nlm.nih.gov/pubmed/25310980 PubMed 3298242 http://www.ncbi.nlm.nih.gov/pubmed/3298242 PubMed 354687 http://www.ncbi.nlm.nih.gov/pubmed/354687 PubMed 8925931 http://www.ncbi.nlm.nih.gov/pubmed/8925931 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9799245 http://www.ncbi.nlm.nih.gov/pubmed/9799245 PubMed 9868784 http://www.ncbi.nlm.nih.gov/pubmed/9868784 RefSeq NP_416690 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416690 RefSeq WP_000494183 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000494183 SMR P68919 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P68919 STRING 511145.b2185 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2185&targetmode=cogs STRING COG1825 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1825&targetmode=cogs SUPFAM SSF50715 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50715 SWISS-2DPAGE P68919 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P68919 UniProtKB RL25_ECOLI http://www.uniprot.org/uniprot/RL25_ECOLI UniProtKB-AC P68919 http://www.uniprot.org/uniprot/P68919 charge swissprot:RL25_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RL25_ECOLI eggNOG COG1825 http://eggnogapi.embl.de/nog_data/html/tree/COG1825 eggNOG ENOG4105KW6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KW6 epestfind swissprot:RL25_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RL25_ECOLI garnier swissprot:RL25_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RL25_ECOLI helixturnhelix swissprot:RL25_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RL25_ECOLI hmoment swissprot:RL25_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RL25_ECOLI iep swissprot:RL25_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RL25_ECOLI inforesidue swissprot:RL25_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RL25_ECOLI octanol swissprot:RL25_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RL25_ECOLI pepcoil swissprot:RL25_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RL25_ECOLI pepdigest swissprot:RL25_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RL25_ECOLI pepinfo swissprot:RL25_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RL25_ECOLI pepnet swissprot:RL25_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RL25_ECOLI pepstats swissprot:RL25_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RL25_ECOLI pepwheel swissprot:RL25_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RL25_ECOLI pepwindow swissprot:RL25_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RL25_ECOLI sigcleave swissprot:RL25_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RL25_ECOLI ## Database ID URL or Descriptions # AltName RPIR_ECOLI Als operon repressor # BioGrid 4262682 10 # EcoGene EG12459 rpiR # FUNCTION RPIR_ECOLI Regulatory protein involved in rpiB gene repression. Also involved in als operon repression. {ECO 0000269|PubMed 9401019}. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_function GO:0030246 carbohydrate binding; IEA:InterPro. # GO_process GO:0005975 carbohydrate metabolic process; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # IntAct P0ACS7 5 # InterPro IPR000281 HTH_RpiR # InterPro IPR001347 SIS # InterPro IPR009057 Homeodomain-like # InterPro IPR011991 WHTH_DNA-bd_dom # Organism RPIR_ECOLI Escherichia coli (strain K12) # PATRIC 32123735 VBIEscCol129921_4216 # PIR S56317 S56317 # PROSITE PS51071 HTH_RPIR # PROSITE PS51464 SIS # Pfam PF01380 SIS # Pfam PF01418 HTH_6 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RPIR_ECOLI HTH-type transcriptional regulator RpiR # RefSeq NP_418513 NC_000913.3 # RefSeq WP_000083216 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA96988.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Contains 1 HTH rpiR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00390}. # SIMILARITY Contains 1 SIS domain. {ECO:0000255|PROSITE- ProRule PRU00797}. # SUPFAM SSF46689 SSF46689 # eggNOG COG1737 LUCA # eggNOG ENOG4105NYY Bacteria BLAST swissprot:RPIR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RPIR_ECOLI BioCyc ECOL316407:JW4050-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4050-MONOMER BioCyc EcoCyc:G7821-MONOMER http://biocyc.org/getid?id=EcoCyc:G7821-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X82203 http://www.ebi.ac.uk/ena/data/view/X82203 EchoBASE EB2353 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2353 EcoGene EG12459 http://www.ecogene.org/geneInfo.php?eg_id=EG12459 EnsemblBacteria AAC77050 http://www.ensemblgenomes.org/id/AAC77050 EnsemblBacteria AAC77050 http://www.ensemblgenomes.org/id/AAC77050 EnsemblBacteria BAE78092 http://www.ensemblgenomes.org/id/BAE78092 EnsemblBacteria BAE78092 http://www.ensemblgenomes.org/id/BAE78092 EnsemblBacteria BAE78092 http://www.ensemblgenomes.org/id/BAE78092 EnsemblBacteria b4089 http://www.ensemblgenomes.org/id/b4089 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0030246 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030246 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 948603 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948603 HOGENOM HOG000027157 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000027157&db=HOGENOM6 InParanoid P0ACS7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACS7 IntAct P0ACS7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACS7* InterPro IPR000281 http://www.ebi.ac.uk/interpro/entry/IPR000281 InterPro IPR001347 http://www.ebi.ac.uk/interpro/entry/IPR001347 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW4050 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4050 KEGG_Gene eco:b4089 http://www.genome.jp/dbget-bin/www_bget?eco:b4089 OMA DSHMMLM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DSHMMLM PROSITE PS51071 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51071 PROSITE PS51464 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51464 PSORT swissprot:RPIR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RPIR_ECOLI PSORT-B swissprot:RPIR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RPIR_ECOLI PSORT2 swissprot:RPIR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RPIR_ECOLI Pfam PF01380 http://pfam.xfam.org/family/PF01380 Pfam PF01418 http://pfam.xfam.org/family/PF01418 Phobius swissprot:RPIR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RPIR_ECOLI PhylomeDB P0ACS7 http://phylomedb.org/?seqid=P0ACS7 ProteinModelPortal P0ACS7 http://www.proteinmodelportal.org/query/uniprot/P0ACS7 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8576032 http://www.ncbi.nlm.nih.gov/pubmed/8576032 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9401019 http://www.ncbi.nlm.nih.gov/pubmed/9401019 RefSeq NP_418513 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418513 RefSeq WP_000083216 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000083216 SMR P0ACS7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACS7 STRING 511145.b4089 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4089&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 UniProtKB RPIR_ECOLI http://www.uniprot.org/uniprot/RPIR_ECOLI UniProtKB-AC P0ACS7 http://www.uniprot.org/uniprot/P0ACS7 charge swissprot:RPIR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RPIR_ECOLI eggNOG COG1737 http://eggnogapi.embl.de/nog_data/html/tree/COG1737 eggNOG ENOG4105NYY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105NYY epestfind swissprot:RPIR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RPIR_ECOLI garnier swissprot:RPIR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RPIR_ECOLI helixturnhelix swissprot:RPIR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RPIR_ECOLI hmoment swissprot:RPIR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RPIR_ECOLI iep swissprot:RPIR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RPIR_ECOLI inforesidue swissprot:RPIR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RPIR_ECOLI octanol swissprot:RPIR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RPIR_ECOLI pepcoil swissprot:RPIR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RPIR_ECOLI pepdigest swissprot:RPIR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RPIR_ECOLI pepinfo swissprot:RPIR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RPIR_ECOLI pepnet swissprot:RPIR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RPIR_ECOLI pepstats swissprot:RPIR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RPIR_ECOLI pepwheel swissprot:RPIR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RPIR_ECOLI pepwindow swissprot:RPIR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RPIR_ECOLI sigcleave swissprot:RPIR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RPIR_ECOLI ## Database ID URL or Descriptions # AltName NANM_ECOLI N-acetylneuraminate mutarotase # AltName NANM_ECOLI Sialic acid epimerase # BRENDA 5.1.3.24 2026 # BioGrid 4259377 10 # CATALYTIC ACTIVITY NANM_ECOLI N-acetyl-alpha-neuraminate = N-acetyl-beta- neuraminate. # EcoGene EG12562 nanM # FUNCTION NANM_ECOLI Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses. {ECO 0000269|PubMed 18063573}. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives; IDA:EcoCyc. # GO_process GO:0005975 carbohydrate metabolic process; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0005975 carbohydrate metabolic process # Gene3D 2.120.10.80 -; 2. # HAMAP MF_01195 NanM # INDUCTION Induced by N-acetylneuraminate and modulated by N- acetylglucosamine, via the NanR and NagC regulators. {ECO:0000269|PubMed 15743943}. # InterPro IPR006652 Kelch_1 # InterPro IPR015915 Kelch-typ_b-propeller # InterPro IPR019936 Mutatrotase_YjhT-like # MASS SPECTROMETRY Mass=38685; Mass_error=4; Method=Electrospray; Range=20-368; Evidence={ECO:0000269|PubMed 18063573}; # Organism NANM_ECOLI Escherichia coli (strain K12) # PATRIC 32124214 VBIEscCol129921_4450 # PDB 2UVK X-ray; 1.50 A; A/B=20-368 # PIR S56535 S56535 # Pfam PF01344 Kelch_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NANM_ECOLI N-acetylneuraminate epimerase # RefSeq NP_418730 NC_000913.3 # RefSeq WP_001309184 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97206.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the NanM family. {ECO 0000305}. # SIMILARITY Contains 7 Kelch repeats. {ECO 0000305}. # SUBCELLULAR LOCATION NANM_ECOLI Periplasm {ECO 0000269|PubMed 18063573}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 18063573}. # TIGRFAMs TIGR03547 muta_rot_YjhT # eggNOG COG3055 LUCA # eggNOG ENOG4108MX5 Bacteria BLAST swissprot:NANM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NANM_ECOLI BioCyc ECOL316407:JW5777-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5777-MONOMER BioCyc EcoCyc:G7920-MONOMER http://biocyc.org/getid?id=EcoCyc:G7920-MONOMER BioCyc MetaCyc:G7920-MONOMER http://biocyc.org/getid?id=MetaCyc:G7920-MONOMER DIP DIP-12628N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12628N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M707822200 http://dx.doi.org/10.1074/jbc.M707822200 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.187.6.1959-1965.2005 http://dx.doi.org/10.1128/JB.187.6.1959-1965.2005 EC_number EC:5.1.3.24 http://www.genome.jp/dbget-bin/www_bget?EC:5.1.3.24 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 5.1.3.24 http://enzyme.expasy.org/EC/5.1.3.24 EchoBASE EB2450 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2450 EcoGene EG12562 http://www.ecogene.org/geneInfo.php?eg_id=EG12562 EnsemblBacteria AAC77266 http://www.ensemblgenomes.org/id/AAC77266 EnsemblBacteria AAC77266 http://www.ensemblgenomes.org/id/AAC77266 EnsemblBacteria BAE78303 http://www.ensemblgenomes.org/id/BAE78303 EnsemblBacteria BAE78303 http://www.ensemblgenomes.org/id/BAE78303 EnsemblBacteria BAE78303 http://www.ensemblgenomes.org/id/BAE78303 EnsemblBacteria b4310 http://www.ensemblgenomes.org/id/b4310 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0016857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016857 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 Gene3D 2.120.10.80 http://www.cathdb.info/version/latest/superfamily/2.120.10.80 GeneID 949106 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949106 HAMAP MF_01195 http://hamap.expasy.org/unirule/MF_01195 HOGENOM HOG000218207 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218207&db=HOGENOM6 InParanoid P39371 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39371 IntEnz 5.1.3.24 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.1.3.24 InterPro IPR006652 http://www.ebi.ac.uk/interpro/entry/IPR006652 InterPro IPR015915 http://www.ebi.ac.uk/interpro/entry/IPR015915 InterPro IPR019936 http://www.ebi.ac.uk/interpro/entry/IPR019936 KEGG_Gene ecj:JW5777 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5777 KEGG_Gene eco:b4310 http://www.genome.jp/dbget-bin/www_bget?eco:b4310 OMA GAAFTIQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GAAFTIQ PDB 2UVK http://www.ebi.ac.uk/pdbe-srv/view/entry/2UVK PDBsum 2UVK http://www.ebi.ac.uk/pdbsum/2UVK PSORT swissprot:NANM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NANM_ECOLI PSORT-B swissprot:NANM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NANM_ECOLI PSORT2 swissprot:NANM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NANM_ECOLI Pfam PF01344 http://pfam.xfam.org/family/PF01344 Phobius swissprot:NANM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NANM_ECOLI PhylomeDB P39371 http://phylomedb.org/?seqid=P39371 ProteinModelPortal P39371 http://www.proteinmodelportal.org/query/uniprot/P39371 PubMed 15743943 http://www.ncbi.nlm.nih.gov/pubmed/15743943 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18063573 http://www.ncbi.nlm.nih.gov/pubmed/18063573 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418730 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418730 RefSeq WP_001309184 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001309184 SMR P39371 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39371 STRING 511145.b4310 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4310&targetmode=cogs TIGRFAMs TIGR03547 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03547 UniProtKB NANM_ECOLI http://www.uniprot.org/uniprot/NANM_ECOLI UniProtKB-AC P39371 http://www.uniprot.org/uniprot/P39371 charge swissprot:NANM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NANM_ECOLI eggNOG COG3055 http://eggnogapi.embl.de/nog_data/html/tree/COG3055 eggNOG ENOG4108MX5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MX5 epestfind swissprot:NANM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NANM_ECOLI garnier swissprot:NANM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NANM_ECOLI helixturnhelix swissprot:NANM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NANM_ECOLI hmoment swissprot:NANM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NANM_ECOLI iep swissprot:NANM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NANM_ECOLI inforesidue swissprot:NANM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NANM_ECOLI octanol swissprot:NANM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NANM_ECOLI pepcoil swissprot:NANM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NANM_ECOLI pepdigest swissprot:NANM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NANM_ECOLI pepinfo swissprot:NANM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NANM_ECOLI pepnet swissprot:NANM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NANM_ECOLI pepstats swissprot:NANM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NANM_ECOLI pepwheel swissprot:NANM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NANM_ECOLI pepwindow swissprot:NANM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NANM_ECOLI sigcleave swissprot:NANM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NANM_ECOLI ## Database ID URL or Descriptions # AltName GCVA_ECOLI Gcv operon activator # BioGrid 4261124 25 # EcoGene EG11795 gcvA # FUNCTION GCVA_ECOLI Regulatory protein for the glycine cleavage system operon (gcv). Mediates activation of gcv by glycine and repression by purines. GcvA is negatively autoregulated. Binds to three sites upstream of the gcv promoter. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0001131 transcription factor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding; IDA:EcoCyc. # GO_function GO:0043565 sequence-specific DNA binding; IBA:GO_Central. # GO_process GO:0006351 transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IDA:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # IntAct P0A9F6 2 # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR005119 LysR_subst-bd # InterPro IPR011991 WHTH_DNA-bd_dom # KEGG_Brite ko03000 Transcription factors # Organism GCVA_ECOLI Escherichia coli (strain K12) # PATRIC 32121032 VBIEscCol129921_2908 # PIR I41065 I41065 # PRINTS PR00039 HTHLYSR # PROSITE PS50931 HTH_LYSR # Pfam PF00126 HTH_1 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GCVA_ECOLI Glycine cleavage system transcriptional activator # RefSeq NP_417288 NC_000913.3 # RefSeq WP_000044401 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lysR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00253}. # SUBCELLULAR LOCATION GCVA_ECOLI Cytoplasm. # SUPFAM SSF46785 SSF46785 # eggNOG ENOG4105ETT Bacteria # eggNOG ENOG410XS6G LUCA BLAST swissprot:GCVA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GCVA_ECOLI BioCyc ECOL316407:JW2779-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2779-MONOMER BioCyc EcoCyc:PD00339 http://biocyc.org/getid?id=EcoCyc:PD00339 COG COG0583 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0583 DIP DIP-9751N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9751N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1099/13500872-141-2-419 http://dx.doi.org/10.1099/13500872-141-2-419 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U01030 http://www.ebi.ac.uk/ena/data/view/U01030 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 EMBL X73413 http://www.ebi.ac.uk/ena/data/view/X73413 EchoBASE EB1743 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1743 EcoGene EG11795 http://www.ecogene.org/geneInfo.php?eg_id=EG11795 EnsemblBacteria AAC75850 http://www.ensemblgenomes.org/id/AAC75850 EnsemblBacteria AAC75850 http://www.ensemblgenomes.org/id/AAC75850 EnsemblBacteria BAE76880 http://www.ensemblgenomes.org/id/BAE76880 EnsemblBacteria BAE76880 http://www.ensemblgenomes.org/id/BAE76880 EnsemblBacteria BAE76880 http://www.ensemblgenomes.org/id/BAE76880 EnsemblBacteria b2808 http://www.ensemblgenomes.org/id/b2808 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0001131 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001131 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 947278 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947278 HOGENOM HOG000233528 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000233528&db=HOGENOM6 InParanoid P0A9F6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9F6 IntAct P0A9F6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9F6* InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW2779 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2779 KEGG_Gene eco:b2808 http://www.genome.jp/dbget-bin/www_bget?eco:b2808 KEGG_Orthology KO:K03566 http://www.genome.jp/dbget-bin/www_bget?KO:K03566 OMA DMQQQIN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DMQQQIN PRINTS PR00039 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00039 PROSITE PS50931 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50931 PSORT swissprot:GCVA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GCVA_ECOLI PSORT-B swissprot:GCVA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GCVA_ECOLI PSORT2 swissprot:GCVA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GCVA_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:GCVA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GCVA_ECOLI PhylomeDB P0A9F6 http://phylomedb.org/?seqid=P0A9F6 ProteinModelPortal P0A9F6 http://www.proteinmodelportal.org/query/uniprot/P0A9F6 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7704273 http://www.ncbi.nlm.nih.gov/pubmed/7704273 PubMed 8188587 http://www.ncbi.nlm.nih.gov/pubmed/8188587 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417288 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417288 RefSeq WP_000044401 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000044401 SMR P0A9F6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9F6 STRING 511145.b2808 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2808&targetmode=cogs STRING COG0583 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0583&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB GCVA_ECOLI http://www.uniprot.org/uniprot/GCVA_ECOLI UniProtKB-AC P0A9F6 http://www.uniprot.org/uniprot/P0A9F6 charge swissprot:GCVA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GCVA_ECOLI eggNOG ENOG4105ETT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ETT eggNOG ENOG410XS6G http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XS6G epestfind swissprot:GCVA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GCVA_ECOLI garnier swissprot:GCVA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GCVA_ECOLI helixturnhelix swissprot:GCVA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GCVA_ECOLI hmoment swissprot:GCVA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GCVA_ECOLI iep swissprot:GCVA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GCVA_ECOLI inforesidue swissprot:GCVA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GCVA_ECOLI octanol swissprot:GCVA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GCVA_ECOLI pepcoil swissprot:GCVA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GCVA_ECOLI pepdigest swissprot:GCVA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GCVA_ECOLI pepinfo swissprot:GCVA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GCVA_ECOLI pepnet swissprot:GCVA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GCVA_ECOLI pepstats swissprot:GCVA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GCVA_ECOLI pepwheel swissprot:GCVA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GCVA_ECOLI pepwindow swissprot:GCVA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GCVA_ECOLI sigcleave swissprot:GCVA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GCVA_ECOLI ## Database ID URL or Descriptions # AltName ATP synthase F1 sector subunit beta {ECO:0000255|HAMAP-Rule MF_01347} # AltName F-ATPase subunit beta {ECO:0000255|HAMAP-Rule MF_01347} # CATALYTIC ACTIVITY ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out). {ECO:0000255|HAMAP-Rule MF_01347}. # EcoGene EG10101 atpD # FUNCTION ATPB_ECOLI Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_component GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1); IMP:EcoliWiki. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0046933 proton-transporting ATP synthase activity, rotational mechanism; IEA:UniProtKB-HAMAP. # GO_function GO:0046961 proton-transporting ATPase activity, rotational mechanism; IMP:EcoCyc. # GO_process GO:0015986 ATP synthesis coupled proton transport; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0055085 transmembrane transport # Gene3D 1.10.1140.10 -; 1. # Gene3D 3.40.50.300 -; 1. # HAMAP MF_01347 ATP_synth_beta_bact # INTERACTION ATPB_ECOLI P0ABB0 atpA; NbExp=10; IntAct=EBI-368783, EBI-368707; # IntAct P0ABB4 31 # InterPro IPR000194 ATPase_F1/V1/A1_a/bsu_nucl-bd # InterPro IPR003593 AAA+_ATPase # InterPro IPR004100 ATPase_F1/V1/A1_a/bsu_N # InterPro IPR005722 ATP_synth_F1_bsu # InterPro IPR020003 ATPase_a/bsu_AS # InterPro IPR024034 ATPase_F1/V1_bsu_C # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko00194 Photosynthesis proteins # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00190 Oxidative phosphorylation # KEGG_Pathway ko00195 Photosynthesis # Organism ATPB_ECOLI Escherichia coli (strain K12) # PATRIC 32122961 VBIEscCol129921_3856 # PDB 1D8S X-ray; 4.40 A; D/E/F=1-460 # PDB 3OAA X-ray; 3.26 A; D/E/F/L/M/N/T/U/V/b/c/d=2-460 # PIR A93742 PWECB # PROSITE PS00152 ATPASE_ALPHA_BETA # Pfam PF00006 ATP-synt_ab # Pfam PF02874 ATP-synt_ab_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ATP synthase subunit beta {ECO:0000255|HAMAP-Rule MF_01347} # RefSeq NP_418188 NC_000913.3 # RefSeq WP_000190506 NZ_LN832404.1 # SIMILARITY Belongs to the ATPase alpha/beta chains family. {ECO:0000255|HAMAP-Rule MF_01347}. # SMART SM00382 AAA # SUBCELLULAR LOCATION ATPB_ECOLI Cell inner membrane; Peripheral membrane protein. # SUBUNIT F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains. # SUPFAM SSF50615 SSF50615 # SUPFAM SSF52540 SSF52540 # TCDB 3.A.2.1 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily # TIGRFAMs TIGR01039 atpD # eggNOG COG0055 LUCA # eggNOG ENOG4105C4J Bacteria BLAST swissprot:ATPB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ATPB_ECOLI BioCyc ECOL316407:JW3710-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3710-MONOMER BioCyc EcoCyc:ATPD-MONOMER http://biocyc.org/getid?id=EcoCyc:ATPD-MONOMER BioCyc MetaCyc:ATPD-MONOMER http://biocyc.org/getid?id=MetaCyc:ATPD-MONOMER COG COG0055 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0055 DIP DIP-31846N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31846N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1016/0006-291X(81)90494-0 http://dx.doi.org/10.1016/0006-291X(81)90494-0 DOI 10.1016/0006-291X(82)90922-6 http://dx.doi.org/10.1016/0006-291X(82)90922-6 DOI 10.1016/0014-5793(87)80326-5 http://dx.doi.org/10.1016/0014-5793(87)80326-5 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2240799 http://dx.doi.org/10.1042/bj2240799 DOI 10.1073/pnas.96.24.13697 http://dx.doi.org/10.1073/pnas.96.24.13697 DOI 10.1093/nar/9.20.5287 http://dx.doi.org/10.1093/nar/9.20.5287 DOI 10.1111/j.1749-6632.1982.tb25731.x http://dx.doi.org/10.1111/j.1749-6632.1982.tb25731.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.3.14 {ECO:0000255|HAMAP-Rule:MF_01347} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.14 {ECO:0000255|HAMAP-Rule:MF_01347} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01594 http://www.ebi.ac.uk/ena/data/view/J01594 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M25464 http://www.ebi.ac.uk/ena/data/view/M25464 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00267 http://www.ebi.ac.uk/ena/data/view/V00267 EMBL V00311 http://www.ebi.ac.uk/ena/data/view/V00311 EMBL V00312 http://www.ebi.ac.uk/ena/data/view/V00312 EMBL X01631 http://www.ebi.ac.uk/ena/data/view/X01631 ENZYME 3.6.3.14 {ECO:0000255|HAMAP-Rule:MF_01347} http://enzyme.expasy.org/EC/3.6.3.14 {ECO:0000255|HAMAP-Rule:MF_01347} EchoBASE EB0099 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0099 EcoGene EG10101 http://www.ecogene.org/geneInfo.php?eg_id=EG10101 EnsemblBacteria AAC76755 http://www.ensemblgenomes.org/id/AAC76755 EnsemblBacteria AAC76755 http://www.ensemblgenomes.org/id/AAC76755 EnsemblBacteria BAE77556 http://www.ensemblgenomes.org/id/BAE77556 EnsemblBacteria BAE77556 http://www.ensemblgenomes.org/id/BAE77556 EnsemblBacteria BAE77556 http://www.ensemblgenomes.org/id/BAE77556 EnsemblBacteria b3732 http://www.ensemblgenomes.org/id/b3732 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0045261 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045261 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0046933 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046933 GO_function GO:0046961 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046961 GO_process GO:0015986 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015986 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 1.10.1140.10 http://www.cathdb.info/version/latest/superfamily/1.10.1140.10 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948244 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948244 HAMAP MF_01347 http://hamap.expasy.org/unirule/MF_01347 HOGENOM HOG000009605 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009605&db=HOGENOM6 InParanoid P0ABB4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABB4 IntAct P0ABB4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABB4* IntEnz 3.6.3.14 {ECO:0000255|HAMAP-Rule:MF_01347} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.14 {ECO:0000255|HAMAP-Rule:MF_01347} InterPro IPR000194 http://www.ebi.ac.uk/interpro/entry/IPR000194 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR004100 http://www.ebi.ac.uk/interpro/entry/IPR004100 InterPro IPR005722 http://www.ebi.ac.uk/interpro/entry/IPR005722 InterPro IPR020003 http://www.ebi.ac.uk/interpro/entry/IPR020003 InterPro IPR024034 http://www.ebi.ac.uk/interpro/entry/IPR024034 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko00194 http://www.genome.jp/dbget-bin/www_bget?ko00194 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3710 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3710 KEGG_Gene eco:b3732 http://www.genome.jp/dbget-bin/www_bget?eco:b3732 KEGG_Orthology KO:K02112 http://www.genome.jp/dbget-bin/www_bget?KO:K02112 KEGG_Pathway ko00190 http://www.genome.jp/kegg-bin/show_pathway?ko00190 KEGG_Pathway ko00195 http://www.genome.jp/kegg-bin/show_pathway?ko00195 MINT MINT-1251407 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1251407 OMA AEFGIYP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AEFGIYP PDB 1D8S http://www.ebi.ac.uk/pdbe-srv/view/entry/1D8S PDB 3OAA http://www.ebi.ac.uk/pdbe-srv/view/entry/3OAA PDBsum 1D8S http://www.ebi.ac.uk/pdbsum/1D8S PDBsum 3OAA http://www.ebi.ac.uk/pdbsum/3OAA PROSITE PS00152 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00152 PSORT swissprot:ATPB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ATPB_ECOLI PSORT-B swissprot:ATPB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ATPB_ECOLI PSORT2 swissprot:ATPB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ATPB_ECOLI Pfam PF00006 http://pfam.xfam.org/family/PF00006 Pfam PF02874 http://pfam.xfam.org/family/PF02874 Phobius swissprot:ATPB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ATPB_ECOLI PhylomeDB P0ABB4 http://phylomedb.org/?seqid=P0ABB4 ProteinModelPortal P0ABB4 http://www.proteinmodelportal.org/query/uniprot/P0ABB4 PubMed 10570135 http://www.ncbi.nlm.nih.gov/pubmed/10570135 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1832155 http://www.ncbi.nlm.nih.gov/pubmed/1832155 PubMed 2889623 http://www.ncbi.nlm.nih.gov/pubmed/2889623 PubMed 6272217 http://www.ncbi.nlm.nih.gov/pubmed/6272217 PubMed 6277310 http://www.ncbi.nlm.nih.gov/pubmed/6277310 PubMed 6285901 http://www.ncbi.nlm.nih.gov/pubmed/6285901 PubMed 6301339 http://www.ncbi.nlm.nih.gov/pubmed/6301339 PubMed 6395859 http://www.ncbi.nlm.nih.gov/pubmed/6395859 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_418188 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418188 RefSeq WP_000190506 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000190506 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P0ABB4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABB4 STRING 511145.b3732 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3732&targetmode=cogs STRING COG0055 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0055&targetmode=cogs SUPFAM SSF50615 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50615 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SWISS-2DPAGE P0ABB4 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0ABB4 TCDB 3.A.2.1 http://www.tcdb.org/search/result.php?tc=3.A.2.1 TIGRFAMs TIGR01039 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01039 UniProtKB ATPB_ECOLI http://www.uniprot.org/uniprot/ATPB_ECOLI UniProtKB-AC P0ABB4 http://www.uniprot.org/uniprot/P0ABB4 charge swissprot:ATPB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ATPB_ECOLI eggNOG COG0055 http://eggnogapi.embl.de/nog_data/html/tree/COG0055 eggNOG ENOG4105C4J http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C4J epestfind swissprot:ATPB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ATPB_ECOLI garnier swissprot:ATPB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ATPB_ECOLI helixturnhelix swissprot:ATPB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ATPB_ECOLI hmoment swissprot:ATPB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ATPB_ECOLI iep swissprot:ATPB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ATPB_ECOLI inforesidue swissprot:ATPB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ATPB_ECOLI octanol swissprot:ATPB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ATPB_ECOLI pepcoil swissprot:ATPB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ATPB_ECOLI pepdigest swissprot:ATPB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ATPB_ECOLI pepinfo swissprot:ATPB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ATPB_ECOLI pepnet swissprot:ATPB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ATPB_ECOLI pepstats swissprot:ATPB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ATPB_ECOLI pepwheel swissprot:ATPB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ATPB_ECOLI pepwindow swissprot:ATPB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ATPB_ECOLI sigcleave swissprot:ATPB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ATPB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260283 40 # EcoGene EG11378 sufA # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0005198 structural molecule activity; IEA:InterPro. # GO_function GO:0008198 ferrous iron binding; IBA:GO_Central. # GO_function GO:0051537 2 iron, 2 sulfur cluster binding; IDA:EcoCyc. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IBA:GO_Central. # GO_process GO:0006790 sulfur compound metabolic process; IBA:GO_Central. # GO_process GO:0006979 response to oxidative stress; IMP:EcoCyc. # GO_process GO:0016226 iron-sulfur cluster assembly; IMP:EcoCyc. # GO_process GO:0097428 protein maturation by iron-sulfur cluster transfer; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0005198 structural molecule activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0051186 cofactor metabolic process # GOslim_process GO:0051604 protein maturation # Gene3D 2.60.300.12 -; 1. # INTERACTION SUFA_ECOLI P77522 sufB; NbExp=5; IntAct=EBI-1125011, EBI-562758; P77499 sufC; NbExp=5; IntAct=EBI-1125011, EBI-561601; # IntAct P77667 8 # InterPro IPR000361 FeS_biogenesis # InterPro IPR011298 SufA_proteobacteria # InterPro IPR016092 FeS_cluster_insertion # InterPro IPR017870 FeS_cluster_insertion_CS # Organism SUFA_ECOLI Escherichia coli (strain K12) # PATRIC 32118674 VBIEscCol129921_1755 # PDB 2D2A X-ray; 2.70 A; A/B=1-122 # PIR D64926 D64926 # PROSITE PS01152 HESB # Pfam PF01521 Fe-S_biosyn # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SUFA_ECOLI Protein SufA # RefSeq NP_416199 NC_000913.3 # RefSeq WP_000367160 NZ_LN832404.1 # SIMILARITY Belongs to the HesB/IscA family. {ECO 0000305}. # SUPFAM SSF89360 SSF89360 # TIGRFAMs TIGR00049 TIGR00049 # TIGRFAMs TIGR01997 sufA_proteo # eggNOG COG0316 LUCA # eggNOG ENOG4108Z4V Bacteria BLAST swissprot:SUFA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SUFA_ECOLI BioCyc ECOL316407:JW1674-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1674-MONOMER BioCyc EcoCyc:EG11378-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11378-MONOMER COG COG0316 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0316 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1352 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1352 EcoGene EG11378 http://www.ecogene.org/geneInfo.php?eg_id=EG11378 EnsemblBacteria AAC74754 http://www.ensemblgenomes.org/id/AAC74754 EnsemblBacteria AAC74754 http://www.ensemblgenomes.org/id/AAC74754 EnsemblBacteria BAA15453 http://www.ensemblgenomes.org/id/BAA15453 EnsemblBacteria BAA15453 http://www.ensemblgenomes.org/id/BAA15453 EnsemblBacteria BAA15453 http://www.ensemblgenomes.org/id/BAA15453 EnsemblBacteria b1684 http://www.ensemblgenomes.org/id/b1684 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0005198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005198 GO_function GO:0008198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008198 GO_function GO:0051537 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051537 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GO_process GO:0006979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979 GO_process GO:0016226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016226 GO_process GO:0097428 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097428 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0005198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005198 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GOslim_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 Gene3D 2.60.300.12 http://www.cathdb.info/version/latest/superfamily/2.60.300.12 GeneID 949014 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949014 HOGENOM HOG000228314 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000228314&db=HOGENOM6 InParanoid P77667 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77667 IntAct P77667 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77667* InterPro IPR000361 http://www.ebi.ac.uk/interpro/entry/IPR000361 InterPro IPR011298 http://www.ebi.ac.uk/interpro/entry/IPR011298 InterPro IPR016092 http://www.ebi.ac.uk/interpro/entry/IPR016092 InterPro IPR017870 http://www.ebi.ac.uk/interpro/entry/IPR017870 KEGG_Gene ecj:JW1674 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1674 KEGG_Gene eco:b1684 http://www.genome.jp/dbget-bin/www_bget?eco:b1684 KEGG_Orthology KO:K05997 http://www.genome.jp/dbget-bin/www_bget?KO:K05997 OMA AVITMTE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AVITMTE PDB 2D2A http://www.ebi.ac.uk/pdbe-srv/view/entry/2D2A PDBsum 2D2A http://www.ebi.ac.uk/pdbsum/2D2A PROSITE PS01152 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01152 PSORT swissprot:SUFA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SUFA_ECOLI PSORT-B swissprot:SUFA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SUFA_ECOLI PSORT2 swissprot:SUFA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SUFA_ECOLI Pfam PF01521 http://pfam.xfam.org/family/PF01521 Phobius swissprot:SUFA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SUFA_ECOLI PhylomeDB P77667 http://phylomedb.org/?seqid=P77667 ProteinModelPortal P77667 http://www.proteinmodelportal.org/query/uniprot/P77667 PubMed 10322040 http://www.ncbi.nlm.nih.gov/pubmed/10322040 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416199 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416199 RefSeq WP_000367160 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000367160 SMR P77667 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77667 STRING 511145.b1684 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1684&targetmode=cogs STRING COG0316 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0316&targetmode=cogs SUPFAM SSF89360 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF89360 TIGRFAMs TIGR00049 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00049 TIGRFAMs TIGR01997 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01997 UniProtKB SUFA_ECOLI http://www.uniprot.org/uniprot/SUFA_ECOLI UniProtKB-AC P77667 http://www.uniprot.org/uniprot/P77667 charge swissprot:SUFA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SUFA_ECOLI eggNOG COG0316 http://eggnogapi.embl.de/nog_data/html/tree/COG0316 eggNOG ENOG4108Z4V http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Z4V epestfind swissprot:SUFA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SUFA_ECOLI garnier swissprot:SUFA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SUFA_ECOLI helixturnhelix swissprot:SUFA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SUFA_ECOLI hmoment swissprot:SUFA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SUFA_ECOLI iep swissprot:SUFA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SUFA_ECOLI inforesidue swissprot:SUFA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SUFA_ECOLI octanol swissprot:SUFA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SUFA_ECOLI pepcoil swissprot:SUFA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SUFA_ECOLI pepdigest swissprot:SUFA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SUFA_ECOLI pepinfo swissprot:SUFA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SUFA_ECOLI pepnet swissprot:SUFA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SUFA_ECOLI pepstats swissprot:SUFA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SUFA_ECOLI pepwheel swissprot:SUFA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SUFA_ECOLI pepwindow swissprot:SUFA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SUFA_ECOLI sigcleave swissprot:SUFA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SUFA_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES YGID_ECOLI Kinetic parameters KM=7.9 mM for L-DOPA {ECO 0000269|PubMed 23666480}; Note=kcat is 0.17 min(-1) with L-DOPA. {ECO 0000269|PubMed 23666480}; pH dependence Optimum pH is 8.0. {ECO 0000269|PubMed 23666480}; # BioGrid 4263035 3 # CATALYTIC ACTIVITY L-dopa + O(2) = 4-(L-alanin-3-yl)-2-hydroxy- cis,cis-muconate 6-semialdehyde. {ECO:0000269|PubMed 23666480}. # CAUTION It is uncertain whether Met-1 or Met-10 is the initiator. {ECO 0000305}. # CDD cd07363 45_DOPA_Dioxygenase # COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI 29105; Evidence={ECO:0000250}; # EcoGene EG11166 ygiD # FUNCTION YGID_ECOLI In vitro, opens the cyclic ring of dihydroxy- phenylalanine (DOPA) between carbons 4 and 5, thus producing an unstable seco-DOPA that rearranges nonenzymatically to betalamic acid. The physiological substrate is unknown. {ECO 0000269|PubMed 23666480}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_function GO:0008198 ferrous iron binding; IEA:InterPro. # GO_function GO:0008270 zinc ion binding; IEA:InterPro. # GO_function GO:0050297 stizolobate synthase activity; IEA:UniProtKB-EC. # GO_process GO:0006725 cellular aromatic compound metabolic process; IEA:InterPro. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # Gene3D 3.40.830.10 -; 1. # IntAct P24197 3 # InterPro IPR004183 Xdiol_dOase_suB # InterPro IPR014436 Extradiol_dOase_DODA # MISCELLANEOUS Betalamic acid is the structural unit of the betalains, natural nitrogen-containing water-soluble pigments with high colorant and bioactive properties, characteristic of plants of the order Caryophyllales. {ECO:0000305|PubMed 23666480}. # Organism YGID_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30096 PTHR30096 # PATRIC 32121488 VBIEscCol129921_3131 # PDB 2PW6 X-ray; 2.27 A; A=1-271 # PIR E65091 E65091 # PIRSF PIRSF006157 Doxgns_DODA # Pfam PF02900 LigB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 4,5-DOPA dioxygenase extradiol {ECO 0000305} # RefSeq NP_417511 NC_000913.3 # SEQUENCE CAUTION Sequence=AAC76075.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the DODA-type extradiol aromatic ring- opening dioxygenase family. {ECO 0000305}. # SUBCELLULAR LOCATION YGID_ECOLI Cytoplasm {ECO 0000269|PubMed 23666480}. # SUBUNIT Monomer. {ECO:0000269|PubMed 23666480}. # SUPFAM SSF53213 SSF53213 # eggNOG COG3384 LUCA # eggNOG ENOG4105C8E Bacteria BLAST swissprot:YGID_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGID_ECOLI BioCyc ECOL316407:JW3007-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3007-MONOMER BioCyc EcoCyc:EG11166-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11166-MONOMER DOI 10.1007/s00253-013-4961-3 http://dx.doi.org/10.1007/s00253-013-4961-3 DOI 10.1016/0167-4781(92)90535-8 http://dx.doi.org/10.1016/0167-4781(92)90535-8 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.13.11.29 {ECO:0000269|PubMed:23666480} http://www.genome.jp/dbget-bin/www_bget?EC:1.13.11.29 {ECO:0000269|PubMed:23666480} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M77129 http://www.ebi.ac.uk/ena/data/view/M77129 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 ENZYME 1.13.11.29 {ECO:0000269|PubMed:23666480} http://enzyme.expasy.org/EC/1.13.11.29 {ECO:0000269|PubMed:23666480} EchoBASE EB1154 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1154 EcoGene EG11166 http://www.ecogene.org/geneInfo.php?eg_id=EG11166 EnsemblBacteria AAC76075 http://www.ensemblgenomes.org/id/AAC76075 EnsemblBacteria AAC76075 http://www.ensemblgenomes.org/id/AAC76075 EnsemblBacteria BAE77095 http://www.ensemblgenomes.org/id/BAE77095 EnsemblBacteria BAE77095 http://www.ensemblgenomes.org/id/BAE77095 EnsemblBacteria BAE77095 http://www.ensemblgenomes.org/id/BAE77095 EnsemblBacteria b3039 http://www.ensemblgenomes.org/id/b3039 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0008198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008198 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0050297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050297 GO_process GO:0006725 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006725 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.830.10 http://www.cathdb.info/version/latest/superfamily/3.40.830.10 GeneID 946447 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946447 HOGENOM HOG000236850 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000236850&db=HOGENOM6 InParanoid P24197 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P24197 IntAct P24197 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P24197* IntEnz 1.13.11.29 {ECO:0000269|PubMed:23666480} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.13.11.29 {ECO:0000269|PubMed:23666480} InterPro IPR004183 http://www.ebi.ac.uk/interpro/entry/IPR004183 InterPro IPR014436 http://www.ebi.ac.uk/interpro/entry/IPR014436 KEGG_Gene ecj:JW3007 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3007 KEGG_Gene eco:b3039 http://www.genome.jp/dbget-bin/www_bget?eco:b3039 PANTHER PTHR30096 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30096 PDB 2PW6 http://www.ebi.ac.uk/pdbe-srv/view/entry/2PW6 PDBsum 2PW6 http://www.ebi.ac.uk/pdbsum/2PW6 PSORT swissprot:YGID_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGID_ECOLI PSORT-B swissprot:YGID_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGID_ECOLI PSORT2 swissprot:YGID_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGID_ECOLI Pfam PF02900 http://pfam.xfam.org/family/PF02900 Phobius swissprot:YGID_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGID_ECOLI PhylomeDB P24197 http://phylomedb.org/?seqid=P24197 ProteinModelPortal P24197 http://www.proteinmodelportal.org/query/uniprot/P24197 PubMed 1314093 http://www.ncbi.nlm.nih.gov/pubmed/1314093 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 23666480 http://www.ncbi.nlm.nih.gov/pubmed/23666480 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417511 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417511 SMR P24197 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P24197 STRING 511145.b3039 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3039&targetmode=cogs SUPFAM SSF53213 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53213 UniProtKB YGID_ECOLI http://www.uniprot.org/uniprot/YGID_ECOLI UniProtKB-AC P24197 http://www.uniprot.org/uniprot/P24197 charge swissprot:YGID_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGID_ECOLI eggNOG COG3384 http://eggnogapi.embl.de/nog_data/html/tree/COG3384 eggNOG ENOG4105C8E http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C8E epestfind swissprot:YGID_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGID_ECOLI garnier swissprot:YGID_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGID_ECOLI helixturnhelix swissprot:YGID_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGID_ECOLI hmoment swissprot:YGID_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGID_ECOLI iep swissprot:YGID_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGID_ECOLI inforesidue swissprot:YGID_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGID_ECOLI octanol swissprot:YGID_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGID_ECOLI pepcoil swissprot:YGID_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGID_ECOLI pepdigest swissprot:YGID_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGID_ECOLI pepinfo swissprot:YGID_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGID_ECOLI pepnet swissprot:YGID_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGID_ECOLI pepstats swissprot:YGID_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGID_ECOLI pepwheel swissprot:YGID_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGID_ECOLI pepwindow swissprot:YGID_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGID_ECOLI sigcleave swissprot:YGID_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGID_ECOLI ## Database ID URL or Descriptions # BioGrid 4261105 101 # EcoGene EG11882 yiiX # IntAct P32167 2 # InterPro IPR024453 Peptidase_C92 # Organism YIIX_ECOLI Escherichia coli (strain K12) # PATRIC 32123391 VBIEscCol129921_4056 # PIR S40880 S40880 # Pfam PF05708 Peptidase_C92 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIIX_ECOLI Uncharacterized protein YiiX # RefSeq NP_418372 NC_000913.3 # RefSeq WP_000797353 NZ_LN832404.1 # SIMILARITY To E.coli YebB. {ECO 0000305}. # eggNOG ENOG4107S01 Bacteria # eggNOG ENOG41115XM LUCA BLAST swissprot:YIIX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIIX_ECOLI BioCyc ECOL316407:JW3908-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3908-MONOMER BioCyc EcoCyc:EG11882-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11882-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U15127 http://www.ebi.ac.uk/ena/data/view/U15127 EchoBASE EB1828 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1828 EcoGene EG11882 http://www.ecogene.org/geneInfo.php?eg_id=EG11882 EnsemblBacteria AAC76919 http://www.ensemblgenomes.org/id/AAC76919 EnsemblBacteria AAC76919 http://www.ensemblgenomes.org/id/AAC76919 EnsemblBacteria BAE77373 http://www.ensemblgenomes.org/id/BAE77373 EnsemblBacteria BAE77373 http://www.ensemblgenomes.org/id/BAE77373 EnsemblBacteria BAE77373 http://www.ensemblgenomes.org/id/BAE77373 EnsemblBacteria b3937 http://www.ensemblgenomes.org/id/b3937 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 948436 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948436 HOGENOM HOG000126696 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126696&db=HOGENOM6 InParanoid P32167 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32167 IntAct P32167 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32167* InterPro IPR024453 http://www.ebi.ac.uk/interpro/entry/IPR024453 KEGG_Gene ecj:JW3908 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3908 KEGG_Gene eco:b3937 http://www.genome.jp/dbget-bin/www_bget?eco:b3937 OMA EAMYCSE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EAMYCSE PSORT swissprot:YIIX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIIX_ECOLI PSORT-B swissprot:YIIX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIIX_ECOLI PSORT2 swissprot:YIIX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIIX_ECOLI Pfam PF05708 http://pfam.xfam.org/family/PF05708 Phobius swissprot:YIIX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIIX_ECOLI PhylomeDB P32167 http://phylomedb.org/?seqid=P32167 ProteinModelPortal P32167 http://www.proteinmodelportal.org/query/uniprot/P32167 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7868617 http://www.ncbi.nlm.nih.gov/pubmed/7868617 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418372 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418372 RefSeq WP_000797353 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000797353 SMR P32167 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32167 STRING 511145.b3937 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3937&targetmode=cogs UniProtKB YIIX_ECOLI http://www.uniprot.org/uniprot/YIIX_ECOLI UniProtKB-AC P32167 http://www.uniprot.org/uniprot/P32167 charge swissprot:YIIX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIIX_ECOLI eggNOG ENOG4107S01 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107S01 eggNOG ENOG41115XM http://eggnogapi.embl.de/nog_data/html/tree/ENOG41115XM epestfind swissprot:YIIX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIIX_ECOLI garnier swissprot:YIIX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIIX_ECOLI helixturnhelix swissprot:YIIX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIIX_ECOLI hmoment swissprot:YIIX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIIX_ECOLI iep swissprot:YIIX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIIX_ECOLI inforesidue swissprot:YIIX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIIX_ECOLI octanol swissprot:YIIX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIIX_ECOLI pepcoil swissprot:YIIX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIIX_ECOLI pepdigest swissprot:YIIX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIIX_ECOLI pepinfo swissprot:YIIX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIIX_ECOLI pepnet swissprot:YIIX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIIX_ECOLI pepstats swissprot:YIIX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIIX_ECOLI pepwheel swissprot:YIIX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIIX_ECOLI pepwindow swissprot:YIIX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIIX_ECOLI sigcleave swissprot:YIIX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIIX_ECOLI ## Database ID URL or Descriptions # BioGrid 4259298 183 # EcoGene EG12941 yhgN # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR002771 Multi_antbiot-R_MarC # Organism YHGN_ECOLI Escherichia coli (strain K12) # PATRIC 32122308 VBIEscCol129921_3531 # PIR E65139 E65139 # Pfam PF01914 MarC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHGN_ECOLI UPF0056 inner membrane protein YhgN # RefSeq NP_417892 NC_000913.3 # RefSeq WP_001002544 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0056 (MarC) family. {ECO 0000305}. # SUBCELLULAR LOCATION YHGN_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.95.1 the 6tms neutral amino acid transporter (naat) family # TIGRFAMs TIGR00427 TIGR00427 # eggNOG COG2095 LUCA # eggNOG ENOG41076UM Bacteria BLAST swissprot:YHGN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHGN_ECOLI BioCyc ECOL316407:JW3397-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3397-MONOMER BioCyc EcoCyc:G7753-MONOMER http://biocyc.org/getid?id=EcoCyc:G7753-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2776 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2776 EcoGene EG12941 http://www.ecogene.org/geneInfo.php?eg_id=EG12941 EnsemblBacteria AAC76459 http://www.ensemblgenomes.org/id/AAC76459 EnsemblBacteria AAC76459 http://www.ensemblgenomes.org/id/AAC76459 EnsemblBacteria BAE77858 http://www.ensemblgenomes.org/id/BAE77858 EnsemblBacteria BAE77858 http://www.ensemblgenomes.org/id/BAE77858 EnsemblBacteria BAE77858 http://www.ensemblgenomes.org/id/BAE77858 EnsemblBacteria b3434 http://www.ensemblgenomes.org/id/b3434 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 947938 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947938 HOGENOM HOG000112970 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000112970&db=HOGENOM6 InParanoid P67143 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P67143 InterPro IPR002771 http://www.ebi.ac.uk/interpro/entry/IPR002771 KEGG_Gene ecj:JW3397 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3397 KEGG_Gene eco:b3434 http://www.genome.jp/dbget-bin/www_bget?eco:b3434 OMA IRMIFPQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IRMIFPQ PSORT swissprot:YHGN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHGN_ECOLI PSORT-B swissprot:YHGN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHGN_ECOLI PSORT2 swissprot:YHGN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHGN_ECOLI Pfam PF01914 http://pfam.xfam.org/family/PF01914 Phobius swissprot:YHGN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHGN_ECOLI PhylomeDB P67143 http://phylomedb.org/?seqid=P67143 ProteinModelPortal P67143 http://www.proteinmodelportal.org/query/uniprot/P67143 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417892 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417892 RefSeq WP_001002544 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001002544 STRING 511145.b3434 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3434&targetmode=cogs TCDB 2.A.95.1 http://www.tcdb.org/search/result.php?tc=2.A.95.1 TIGRFAMs TIGR00427 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00427 UniProtKB YHGN_ECOLI http://www.uniprot.org/uniprot/YHGN_ECOLI UniProtKB-AC P67143 http://www.uniprot.org/uniprot/P67143 charge swissprot:YHGN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHGN_ECOLI eggNOG COG2095 http://eggnogapi.embl.de/nog_data/html/tree/COG2095 eggNOG ENOG41076UM http://eggnogapi.embl.de/nog_data/html/tree/ENOG41076UM epestfind swissprot:YHGN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHGN_ECOLI garnier swissprot:YHGN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHGN_ECOLI helixturnhelix swissprot:YHGN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHGN_ECOLI hmoment swissprot:YHGN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHGN_ECOLI iep swissprot:YHGN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHGN_ECOLI inforesidue swissprot:YHGN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHGN_ECOLI octanol swissprot:YHGN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHGN_ECOLI pepcoil swissprot:YHGN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHGN_ECOLI pepdigest swissprot:YHGN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHGN_ECOLI pepinfo swissprot:YHGN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHGN_ECOLI pepnet swissprot:YHGN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHGN_ECOLI pepstats swissprot:YHGN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHGN_ECOLI pepwheel swissprot:YHGN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHGN_ECOLI pepwindow swissprot:YHGN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHGN_ECOLI sigcleave swissprot:YHGN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHGN_ECOLI ## Database ID URL or Descriptions # AltName Hybrid-cluster protein {ECO:0000255|HAMAP-Rule MF_00069} # AltName Prismane protein {ECO:0000303|PubMed 10651802} # BIOPHYSICOCHEMICAL PROPERTIES HCP_ECOLI Kinetic parameters KM=2.5 mM for hydroxylamine (at pH 9) {ECO 0000269|PubMed 12374823}; Vmax=92 umol/min/mg enzyme (at pH 7.5) {ECO 0000269|PubMed 12374823}; Vmax=458 umol/min/mg enzyme (at pH 9) {ECO 0000269|PubMed 12374823}; pH dependence Optimum pH is 9.0. {ECO 0000269|PubMed 12374823}; # BioGrid 4262100 10 # CATALYTIC ACTIVITY HCP_ECOLI NH(3) + H(2)O + acceptor = hydroxylamine + reduced acceptor. {ECO 0000255|HAMAP-Rule MF_00069, ECO 0000269|PubMed 12374823}. # CDD cd01914 HCP # COFACTOR HCP_ECOLI Name=[2Fe-2S] cluster; Xref=ChEBI CHEBI 49601; Evidence={ECO 0000255|HAMAP-Rule MF_00069, ECO 0000269|PubMed 10381368, ECO 0000269|PubMed 10651802}; Note=Binds 1 [2Fe-2S] cluster. {ECO 0000255|HAMAP-Rule MF_00069, ECO 0000269|PubMed 10381368, ECO 0000269|PubMed 10651802}; # COFACTOR HCP_ECOLI Name=hybrid [4Fe-2O-2S] cluster; Xref=ChEBI CHEBI 60519; Evidence={ECO 0000255|HAMAP-Rule MF_00069, ECO 0000269|PubMed 10381368, ECO 0000269|PubMed 10651802}; Note=Binds 1 hybrid [4Fe-2O-2S] cluster. {ECO 0000255|HAMAP- Rule MF_00069, ECO 0000269|PubMed 10381368, ECO 0000269|PubMed 10651802}; # ENZYME REGULATION Inhibited by oxygen. Activated by cyanide except in the prolonged presence of excess cyanide, where the enzyme is inactivated. {ECO:0000269|PubMed 12374823}. # EcoGene EG13692 hcp # FUNCTION HCP_ECOLI Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. Is also able to reduce hydroxylamine analogs such as methylhydroxylamine and hydroxyquinone. Might have a role as a scavenger of potentially toxic by-products of nitrate metabolism. {ECO 0000255|HAMAP-Rule MF_00069, ECO 0000269|PubMed 10651802, ECO 0000269|PubMed 12374823}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0004601 peroxidase activity; IDA:EcoliWiki. # GO_function GO:0016491 oxidoreductase activity; IDA:EcoliWiki. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0050418 hydroxylamine reductase activity; IDA:EcoCyc. # GO_function GO:0051537 2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0006807 nitrogen compound metabolic process; IDA:EcoCyc. # GO_process GO:0042542 response to hydrogen peroxide; IEP:EcoliWiki. # GO_process GO:0055114 oxidation-reduction process; IMP:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # Gene3D 1.20.1270.20 -; 2. # Gene3D 3.40.50.2030 -; 2. # HAMAP MF_00069 Hydroxylam_reduct # INDUCTION By Fnr, NarL and NarP under anaerobic conditions in the presence of either nitrate or nitrite. {ECO:0000269|PubMed 15667305}. # IntAct P75825 5 # InterPro IPR004137 HCP/CODH # InterPro IPR010048 Hydroxylam_reduct # InterPro IPR011254 Prismane-like # InterPro IPR016099 Prismane-like_a/b-sand # InterPro IPR016100 Prismane_a-bundle # KEGG_Brite ko01000 Enzymes # Organism HCP_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30109:SF0 PTHR30109:SF0 # PATRIC 32116953 VBIEscCol129921_0902 # PIR A64826 A64826 # PIRSF PIRSF000076 HCP # Pfam PF03063 Prismane # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Hydroxylamine reductase {ECO:0000303|PubMed 12374823} # RefSeq NP_415394 NC_000913.3 # RefSeq WP_000458809 NZ_LN832404.1 # SIMILARITY Belongs to the HCP family. {ECO:0000255|HAMAP- Rule MF_00069}. # SUBCELLULAR LOCATION HCP_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00069}. # SUPFAM SSF56821 SSF56821 # TIGRFAMs TIGR01703 hybrid_clust # eggNOG COG1151 LUCA # eggNOG ENOG4105EJ7 Bacteria BLAST swissprot:HCP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HCP_ECOLI BioCyc ECOL316407:JW0857-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0857-MONOMER BioCyc EcoCyc:G6457-MONOMER http://biocyc.org/getid?id=EcoCyc:G6457-MONOMER BioCyc MetaCyc:G6457-MONOMER http://biocyc.org/getid?id=MetaCyc:G6457-MONOMER COG COG1151 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1151 DIP DIP-9870N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9870N DOI 10.1006/bbrc.1999.0748 http://dx.doi.org/10.1006/bbrc.1999.0748 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/BST0330195 http://dx.doi.org/10.1042/BST0330195 DOI 10.1046/j.1432-1327.2000.01032.x http://dx.doi.org/10.1046/j.1432-1327.2000.01032.x DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.21.5898-5902.2002 http://dx.doi.org/10.1128/JB.184.21.5898-5902.2002 EC_number EC:1.7.99.1 {ECO:0000269|PubMed:12374823} http://www.genome.jp/dbget-bin/www_bget?EC:1.7.99.1 {ECO:0000269|PubMed:12374823} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.7.99.1 {ECO:0000269|PubMed:12374823} http://enzyme.expasy.org/EC/1.7.99.1 {ECO:0000269|PubMed:12374823} EchoBASE EB3456 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3456 EcoGene EG13692 http://www.ecogene.org/geneInfo.php?eg_id=EG13692 EnsemblBacteria AAC73960 http://www.ensemblgenomes.org/id/AAC73960 EnsemblBacteria AAC73960 http://www.ensemblgenomes.org/id/AAC73960 EnsemblBacteria BAA35587 http://www.ensemblgenomes.org/id/BAA35587 EnsemblBacteria BAA35587 http://www.ensemblgenomes.org/id/BAA35587 EnsemblBacteria BAA35587 http://www.ensemblgenomes.org/id/BAA35587 EnsemblBacteria b0873 http://www.ensemblgenomes.org/id/b0873 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004601 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004601 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0050418 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050418 GO_function GO:0051537 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051537 GO_process GO:0006807 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006807 GO_process GO:0042542 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042542 GO_process GO:0055114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.20.1270.20 http://www.cathdb.info/version/latest/superfamily/1.20.1270.20 Gene3D 3.40.50.2030 http://www.cathdb.info/version/latest/superfamily/3.40.50.2030 GeneID 946592 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946592 HAMAP MF_00069 http://hamap.expasy.org/unirule/MF_00069 HOGENOM HOG000007176 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000007176&db=HOGENOM6 InParanoid P75825 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75825 IntAct P75825 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75825* IntEnz 1.7.99.1 {ECO:0000269|PubMed:12374823} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.7.99.1 {ECO:0000269|PubMed:12374823} InterPro IPR004137 http://www.ebi.ac.uk/interpro/entry/IPR004137 InterPro IPR010048 http://www.ebi.ac.uk/interpro/entry/IPR010048 InterPro IPR011254 http://www.ebi.ac.uk/interpro/entry/IPR011254 InterPro IPR016099 http://www.ebi.ac.uk/interpro/entry/IPR016099 InterPro IPR016100 http://www.ebi.ac.uk/interpro/entry/IPR016100 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0857 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0857 KEGG_Gene eco:b0873 http://www.genome.jp/dbget-bin/www_bget?eco:b0873 KEGG_Orthology KO:K00378 http://www.genome.jp/dbget-bin/www_bget?KO:K00378 OMA CAYAQGM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CAYAQGM PANTHER PTHR30109:SF0 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30109:SF0 PSORT swissprot:HCP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HCP_ECOLI PSORT-B swissprot:HCP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HCP_ECOLI PSORT2 swissprot:HCP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HCP_ECOLI Pfam PF03063 http://pfam.xfam.org/family/PF03063 Phobius swissprot:HCP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HCP_ECOLI PhylomeDB P75825 http://phylomedb.org/?seqid=P75825 ProteinModelPortal P75825 http://www.proteinmodelportal.org/query/uniprot/P75825 PubMed 10381368 http://www.ncbi.nlm.nih.gov/pubmed/10381368 PubMed 10651802 http://www.ncbi.nlm.nih.gov/pubmed/10651802 PubMed 12374823 http://www.ncbi.nlm.nih.gov/pubmed/12374823 PubMed 15667305 http://www.ncbi.nlm.nih.gov/pubmed/15667305 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415394 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415394 RefSeq WP_000458809 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000458809 SMR P75825 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75825 STRING 511145.b0873 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0873&targetmode=cogs STRING COG1151 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1151&targetmode=cogs SUPFAM SSF56821 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56821 TIGRFAMs TIGR01703 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01703 UniProtKB HCP_ECOLI http://www.uniprot.org/uniprot/HCP_ECOLI UniProtKB-AC P75825 http://www.uniprot.org/uniprot/P75825 charge swissprot:HCP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HCP_ECOLI eggNOG COG1151 http://eggnogapi.embl.de/nog_data/html/tree/COG1151 eggNOG ENOG4105EJ7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EJ7 epestfind swissprot:HCP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HCP_ECOLI garnier swissprot:HCP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HCP_ECOLI helixturnhelix swissprot:HCP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HCP_ECOLI hmoment swissprot:HCP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HCP_ECOLI iep swissprot:HCP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HCP_ECOLI inforesidue swissprot:HCP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HCP_ECOLI octanol swissprot:HCP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HCP_ECOLI pepcoil swissprot:HCP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HCP_ECOLI pepdigest swissprot:HCP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HCP_ECOLI pepinfo swissprot:HCP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HCP_ECOLI pepnet swissprot:HCP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HCP_ECOLI pepstats swissprot:HCP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HCP_ECOLI pepwheel swissprot:HCP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HCP_ECOLI pepwindow swissprot:HCP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HCP_ECOLI sigcleave swissprot:HCP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HCP_ECOLI ## Database ID URL or Descriptions # BioGrid 4261704 4 # EcoGene EG13101 yqeJ # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # Organism YQEJ_ECOLI Escherichia coli (strain K12) # PATRIC 32121114 VBIEscCol129921_2946 # PIR A65068 A65068 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQEJ_ECOLI Uncharacterized protein YqeJ # RefSeq NP_417325 NC_000913.3 # RefSeq WP_000568339 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40495.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SUBCELLULAR LOCATION YQEJ_ECOLI Membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. # eggNOG ENOG4105FV3 Bacteria # eggNOG ENOG4111RBZ LUCA BLAST swissprot:YQEJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQEJ_ECOLI BioCyc ECOL316407:JW5455-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5455-MONOMER BioCyc EcoCyc:G7468-MONOMER http://biocyc.org/getid?id=EcoCyc:G7468-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 EMBL U83187 http://www.ebi.ac.uk/ena/data/view/U83187 EchoBASE EB2904 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2904 EcoGene EG13101 http://www.ecogene.org/geneInfo.php?eg_id=EG13101 EnsemblBacteria AAC75887 http://www.ensemblgenomes.org/id/AAC75887 EnsemblBacteria AAC75887 http://www.ensemblgenomes.org/id/AAC75887 EnsemblBacteria BAE76917 http://www.ensemblgenomes.org/id/BAE76917 EnsemblBacteria BAE76917 http://www.ensemblgenomes.org/id/BAE76917 EnsemblBacteria BAE76917 http://www.ensemblgenomes.org/id/BAE76917 EnsemblBacteria b2848 http://www.ensemblgenomes.org/id/b2848 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GeneID 947328 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947328 HOGENOM HOG000294402 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000294402&db=HOGENOM6 KEGG_Gene ecj:JW5455 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5455 KEGG_Gene eco:b2848 http://www.genome.jp/dbget-bin/www_bget?eco:b2848 OMA EYTWVEN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EYTWVEN PSORT swissprot:YQEJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQEJ_ECOLI PSORT-B swissprot:YQEJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQEJ_ECOLI PSORT2 swissprot:YQEJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQEJ_ECOLI Phobius swissprot:YQEJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQEJ_ECOLI ProteinModelPortal Q46943 http://www.proteinmodelportal.org/query/uniprot/Q46943 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417325 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417325 RefSeq WP_000568339 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000568339 STRING 511145.b2848 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2848&targetmode=cogs UniProtKB YQEJ_ECOLI http://www.uniprot.org/uniprot/YQEJ_ECOLI UniProtKB-AC Q46943 http://www.uniprot.org/uniprot/Q46943 charge swissprot:YQEJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQEJ_ECOLI eggNOG ENOG4105FV3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FV3 eggNOG ENOG4111RBZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111RBZ epestfind swissprot:YQEJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQEJ_ECOLI garnier swissprot:YQEJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQEJ_ECOLI helixturnhelix swissprot:YQEJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQEJ_ECOLI hmoment swissprot:YQEJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQEJ_ECOLI iep swissprot:YQEJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQEJ_ECOLI inforesidue swissprot:YQEJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQEJ_ECOLI octanol swissprot:YQEJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQEJ_ECOLI pepcoil swissprot:YQEJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQEJ_ECOLI pepdigest swissprot:YQEJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQEJ_ECOLI pepinfo swissprot:YQEJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQEJ_ECOLI pepnet swissprot:YQEJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQEJ_ECOLI pepstats swissprot:YQEJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQEJ_ECOLI pepwheel swissprot:YQEJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQEJ_ECOLI pepwindow swissprot:YQEJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQEJ_ECOLI sigcleave swissprot:YQEJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQEJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4262313 550 # CAUTION Could be the product of a pseudogene. The original protein is truncated by the IS2H element which is inserted right before residue 10. The original N-terminal of this protein is not known. {ECO 0000305}. # EcoGene EG13045 ygeO # GO_process GO:0009405 pathogenesis; IEA:InterPro. # GOslim_process GO:0008150 biological_process # InterPro IPR013388 T3SS_OrgA/MxiK # Organism YGEO_ECOLI Escherichia coli (strain K12) # PIR D65069 D65069 # Pfam PF09482 OrgA_MxiK # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGEO_ECOLI Putative uncharacterized protein YgeO # TIGRFAMs TIGR02555 OrgA_MxiK BLAST swissprot:YGEO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGEO_ECOLI BioCyc ECOL316407:JW5846-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5846-MONOMER BioCyc EcoCyc:G7479-MONOMER http://biocyc.org/getid?id=EcoCyc:G7479-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 EcoGene EG13045 http://www.ecogene.org/geneInfo.php?eg_id=EG13045 EnsemblBacteria BAE76926 http://www.ensemblgenomes.org/id/BAE76926 EnsemblBacteria BAE76926 http://www.ensemblgenomes.org/id/BAE76926 EnsemblBacteria BAE76926 http://www.ensemblgenomes.org/id/BAE76926 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0009405 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009405 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 HOGENOM HOG000054883 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000054883&db=HOGENOM6 InterPro IPR013388 http://www.ebi.ac.uk/interpro/entry/IPR013388 KEGG_Gene ecj:JW5846 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5846 OMA ANPINNW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ANPINNW PSORT swissprot:YGEO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGEO_ECOLI PSORT-B swissprot:YGEO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGEO_ECOLI PSORT2 swissprot:YGEO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGEO_ECOLI Pfam PF09482 http://pfam.xfam.org/family/PF09482 Phobius swissprot:YGEO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGEO_ECOLI PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 STRING 316407.85675673 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85675673&targetmode=cogs TIGRFAMs TIGR02555 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02555 UniProtKB YGEO_ECOLI http://www.uniprot.org/uniprot/YGEO_ECOLI UniProtKB-AC Q46795 http://www.uniprot.org/uniprot/Q46795 charge swissprot:YGEO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGEO_ECOLI epestfind swissprot:YGEO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGEO_ECOLI garnier swissprot:YGEO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGEO_ECOLI helixturnhelix swissprot:YGEO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGEO_ECOLI hmoment swissprot:YGEO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGEO_ECOLI iep swissprot:YGEO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGEO_ECOLI inforesidue swissprot:YGEO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGEO_ECOLI octanol swissprot:YGEO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGEO_ECOLI pepcoil swissprot:YGEO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGEO_ECOLI pepdigest swissprot:YGEO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGEO_ECOLI pepinfo swissprot:YGEO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGEO_ECOLI pepnet swissprot:YGEO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGEO_ECOLI pepstats swissprot:YGEO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGEO_ECOLI pepwheel swissprot:YGEO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGEO_ECOLI pepwindow swissprot:YGEO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGEO_ECOLI sigcleave swissprot:YGEO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGEO_ECOLI ## Database ID URL or Descriptions # AltName EX7S_ECOLI Exodeoxyribonuclease VII small subunit # BioGrid 4259844 55 # CATALYTIC ACTIVITY EX7S_ECOLI Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates. # EcoGene EG11098 xseB # FUNCTION EX7S_ECOLI Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides. It can also degrade 3' or 5' ss regions extending from the termini of duplex DNA molecules and displaced ss regions. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0009318 exodeoxyribonuclease VII complex; IEA:InterPro. # GO_function GO:0008855 exodeoxyribonuclease VII activity; IMP:EcoliWiki. # GO_process GO:0006308 DNA catabolic process; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0004518 nuclease activity # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # Gene3D 1.10.287.1040 -; 1. # HAMAP MF_00337 Exonuc_7_S # INTERACTION EX7S_ECOLI P64503 yebV; NbExp=4; IntAct=EBI-1116872, EBI-9126792; # IntAct P0A8G9 4 # InterPro IPR003761 Exonuc_VII_S # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko03430 Mismatch repair # Organism EX7S_ECOLI Escherichia coli (strain K12) # PATRIC 32115993 VBIEscCol129921_0438 # PIR JQ0664 JQ0664 # PIRSF PIRSF006488 Exonuc_VII_S # Pfam PF02609 Exonuc_VII_S # ProDom PD028235 Exonuc_VII_S # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EX7S_ECOLI Exodeoxyribonuclease 7 small subunit # RefSeq NP_414956 NC_000913.3 # RefSeq WP_001124935 NZ_LN832404.1 # SIMILARITY Belongs to the XseB family. {ECO 0000305}. # SUBCELLULAR LOCATION EX7S_ECOLI Cytoplasm. # SUBUNIT Heterooligomer composed of two different subunits with an approximate ratio of 4 small subunits for 1 large. {ECO:0000269|PubMed 6284744}. # TIGRFAMs TIGR01280 xseB # eggNOG COG1722 LUCA # eggNOG ENOG41067QG Bacteria BLAST swissprot:EX7S_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EX7S_ECOLI BioCyc ECOL316407:JW0412-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0412-MONOMER BioCyc EcoCyc:EG11098-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11098-MONOMER BioCyc MetaCyc:EG11098-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11098-MONOMER COG COG1722 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1722 DIP DIP-48031N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48031N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.11.6 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.11.6 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D00694 http://www.ebi.ac.uk/ena/data/view/D00694 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 ENZYME 3.1.11.6 http://enzyme.expasy.org/EC/3.1.11.6 EchoBASE EB1090 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1090 EcoGene EG11098 http://www.ecogene.org/geneInfo.php?eg_id=EG11098 EnsemblBacteria AAC73525 http://www.ensemblgenomes.org/id/AAC73525 EnsemblBacteria AAC73525 http://www.ensemblgenomes.org/id/AAC73525 EnsemblBacteria BAE76202 http://www.ensemblgenomes.org/id/BAE76202 EnsemblBacteria BAE76202 http://www.ensemblgenomes.org/id/BAE76202 EnsemblBacteria BAE76202 http://www.ensemblgenomes.org/id/BAE76202 EnsemblBacteria b0422 http://www.ensemblgenomes.org/id/b0422 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0009318 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009318 GO_function GO:0008855 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008855 GO_process GO:0006308 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006308 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 Gene3D 1.10.287.1040 http://www.cathdb.info/version/latest/superfamily/1.10.287.1040 GeneID 945069 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945069 HAMAP MF_00337 http://hamap.expasy.org/unirule/MF_00337 HOGENOM HOG000228798 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000228798&db=HOGENOM6 InParanoid P0A8G9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8G9 IntAct P0A8G9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8G9* IntEnz 3.1.11.6 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.11.6 InterPro IPR003761 http://www.ebi.ac.uk/interpro/entry/IPR003761 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW0412 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0412 KEGG_Gene eco:b0422 http://www.genome.jp/dbget-bin/www_bget?eco:b0422 KEGG_Orthology KO:K03602 http://www.genome.jp/dbget-bin/www_bget?KO:K03602 KEGG_Pathway ko03430 http://www.genome.jp/kegg-bin/show_pathway?ko03430 OMA APLNDYK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=APLNDYK PSORT swissprot:EX7S_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EX7S_ECOLI PSORT-B swissprot:EX7S_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EX7S_ECOLI PSORT2 swissprot:EX7S_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EX7S_ECOLI Pfam PF02609 http://pfam.xfam.org/family/PF02609 Phobius swissprot:EX7S_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EX7S_ECOLI PhylomeDB P0A8G9 http://phylomedb.org/?seqid=P0A8G9 ProteinModelPortal P0A8G9 http://www.proteinmodelportal.org/query/uniprot/P0A8G9 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2089044 http://www.ncbi.nlm.nih.gov/pubmed/2089044 PubMed 6284744 http://www.ncbi.nlm.nih.gov/pubmed/6284744 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414956 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414956 RefSeq WP_001124935 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001124935 SMR P0A8G9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8G9 STRING 511145.b0422 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0422&targetmode=cogs STRING COG1722 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1722&targetmode=cogs TIGRFAMs TIGR01280 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01280 UniProtKB EX7S_ECOLI http://www.uniprot.org/uniprot/EX7S_ECOLI UniProtKB-AC P0A8G9 http://www.uniprot.org/uniprot/P0A8G9 charge swissprot:EX7S_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EX7S_ECOLI eggNOG COG1722 http://eggnogapi.embl.de/nog_data/html/tree/COG1722 eggNOG ENOG41067QG http://eggnogapi.embl.de/nog_data/html/tree/ENOG41067QG epestfind swissprot:EX7S_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EX7S_ECOLI garnier swissprot:EX7S_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EX7S_ECOLI helixturnhelix swissprot:EX7S_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EX7S_ECOLI hmoment swissprot:EX7S_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EX7S_ECOLI iep swissprot:EX7S_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EX7S_ECOLI inforesidue swissprot:EX7S_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EX7S_ECOLI octanol swissprot:EX7S_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EX7S_ECOLI pepcoil swissprot:EX7S_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EX7S_ECOLI pepdigest swissprot:EX7S_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EX7S_ECOLI pepinfo swissprot:EX7S_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EX7S_ECOLI pepnet swissprot:EX7S_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EX7S_ECOLI pepstats swissprot:EX7S_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EX7S_ECOLI pepwheel swissprot:EX7S_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EX7S_ECOLI pepwindow swissprot:EX7S_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EX7S_ECOLI sigcleave swissprot:EX7S_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EX7S_ECOLI ## Database ID URL or Descriptions # BioGrid 4261563 182 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG14418 ykgN # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 1.10.10.60 -; 1. # INTERACTION YKGN_ECOLI P0ACG8 hslR; NbExp=2; IntAct=EBI-9131095, EBI-562824; # IntAct Q79E92 43 # InterPro IPR002514 Transposase_8 # InterPro IPR009057 Homeodomain-like # Organism YKGN_ECOLI Escherichia coli (strain K12) # PATRIC 48659731 VBIEscCol107702_0261 # PIR I41306 I41306 # Pfam PF01527 HTH_Tnp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YKGN_ECOLI Putative transposase YkgN # RefSeq WP_000015532 NZ_LN832404.1 # SIMILARITY Belongs to the transposase 8 family. {ECO 0000305}. # SUPFAM SSF46689 SSF46689 # eggNOG COG2963 LUCA BLAST swissprot:YKGN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YKGN_ECOLI BioCyc ECOL316407:JW0258-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0258-MONOMER BioCyc EcoCyc:MONOMER0-2655 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2655 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L20943 http://www.ebi.ac.uk/ena/data/view/L20943 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EcoGene EG14418 http://www.ecogene.org/geneInfo.php?eg_id=EG14418 EnsemblBacteria BAA77932 http://www.ensemblgenomes.org/id/BAA77932 EnsemblBacteria BAA77932 http://www.ensemblgenomes.org/id/BAA77932 EnsemblBacteria BAA77932 http://www.ensemblgenomes.org/id/BAA77932 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 InParanoid Q79E92 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q79E92 IntAct Q79E92 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q79E92* InterPro IPR002514 http://www.ebi.ac.uk/interpro/entry/IPR002514 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 KEGG_Gene ecj:JW0258 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0258 PSORT swissprot:YKGN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YKGN_ECOLI PSORT-B swissprot:YKGN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YKGN_ECOLI PSORT2 swissprot:YKGN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YKGN_ECOLI Pfam PF01527 http://pfam.xfam.org/family/PF01527 Phobius swissprot:YKGN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YKGN_ECOLI ProteinModelPortal Q79E92 http://www.proteinmodelportal.org/query/uniprot/Q79E92 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8113168 http://www.ncbi.nlm.nih.gov/pubmed/8113168 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000015532 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000015532 SMR Q79E92 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q79E92 STRING 316407.4902998 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.4902998&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 UniProtKB YKGN_ECOLI http://www.uniprot.org/uniprot/YKGN_ECOLI UniProtKB-AC Q79E92 http://www.uniprot.org/uniprot/Q79E92 charge swissprot:YKGN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YKGN_ECOLI eggNOG COG2963 http://eggnogapi.embl.de/nog_data/html/tree/COG2963 epestfind swissprot:YKGN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YKGN_ECOLI garnier swissprot:YKGN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YKGN_ECOLI helixturnhelix swissprot:YKGN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YKGN_ECOLI hmoment swissprot:YKGN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YKGN_ECOLI iep swissprot:YKGN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YKGN_ECOLI inforesidue swissprot:YKGN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YKGN_ECOLI octanol swissprot:YKGN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YKGN_ECOLI pepcoil swissprot:YKGN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YKGN_ECOLI pepdigest swissprot:YKGN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YKGN_ECOLI pepinfo swissprot:YKGN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YKGN_ECOLI pepnet swissprot:YKGN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YKGN_ECOLI pepstats swissprot:YKGN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YKGN_ECOLI pepwheel swissprot:YKGN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YKGN_ECOLI pepwindow swissprot:YKGN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YKGN_ECOLI sigcleave swissprot:YKGN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YKGN_ECOLI ## Database ID URL or Descriptions # BioGrid 4259201 28 # EcoGene EG10384 glnB # FUNCTION GLNB_ECOLI P-II indirectly controls the transcription of the glutamine synthetase gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of GlnA. When P-II is uridylylated to P-II-UMP, these events are reversed. When the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP, which causes the deadenylation of glutamine synthetase by GlnE, so activating the enzyme. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IDA:EcoCyc. # GO_function GO:0030234 enzyme regulator activity; IDA:EcoCyc. # GO_function GO:0036094 small molecule binding; IMP:EcoCyc. # GO_function GO:0042802 identical protein binding; IPI:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006808 regulation of nitrogen utilization; IDA:EcoCyc. # GO_process GO:0042304 regulation of fatty acid biosynthetic process; IDA:EcoCyc. # GO_process GO:0050790 regulation of catalytic activity; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0030234 enzyme regulator activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.30.70.120 -; 1. # INTERACTION GLNB_ECOLI Self; NbExp=3; IntAct=EBI-551053, EBI-551053; P27249 glnD; NbExp=3; IntAct=EBI-551053, EBI-552032; P0AC55 glnK; NbExp=3; IntAct=EBI-551053, EBI-559503; P0AFB5 glnL; NbExp=5; IntAct=EBI-551053, EBI-701156; P0AF90 rraB; NbExp=2; IntAct=EBI-551053, EBI-544031; # IntAct P0A9Z1 18 # InterPro IPR002187 N-reg_PII # InterPro IPR002332 N-reg_PII_urydylation_site # InterPro IPR011322 N-reg_PII-like_a/b # InterPro IPR015867 N-reg_PII/ATP_PRibTrfase_C # InterPro IPR017918 N-reg_PII_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko02020 Two-component system # Organism GLNB_ECOLI Escherichia coli (strain K12) # PATRIC 32120505 VBIEscCol129921_2655 # PDB 1PIL X-ray; 2.70 A; A=1-112 # PDB 2PII X-ray; 1.90 A; A=1-112 # PIR C49940 RGECP2 # PIRSF PIRSF039144 GlnB # PRINTS PR00340 PIIGLNB # PROSITE PS00496 PII_GLNB_UMP # PROSITE PS00638 PII_GLNB_CTER # PROSITE PS51343 PII_GLNB_DOM # PTM GLNB_ECOLI Uridylylated/deuridylylated by GlnD. # Pfam PF00543 P-II # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLNB_ECOLI Nitrogen regulatory protein P-II 1 # RefSeq NP_417048 NC_000913.3 # RefSeq WP_000717694 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA23883.1; Type=Frameshift; Positions=103, 105; Evidence={ECO 0000305}; # SIMILARITY Belongs to the P(II) protein family. {ECO:0000255|PROSITE-ProRule PRU00675}. # SMART SM00938 P-II # SUBUNIT Homotrimer. {ECO:0000269|PubMed 8293810}. # SUPFAM SSF54913 SSF54913 # eggNOG COG0347 LUCA BLAST swissprot:GLNB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLNB_ECOLI BioCyc ECOL316407:JW2537-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2537-MONOMER BioCyc EcoCyc:PROTEIN-PII http://biocyc.org/getid?id=EcoCyc:PROTEIN-PII BioCyc MetaCyc:PROTEIN-PII http://biocyc.org/getid?id=MetaCyc:PROTEIN-PII COG COG0347 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0347 DIP DIP-35005N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35005N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1007/BF00273586 http://dx.doi.org/10.1007/BF00273586 DOI 10.1007/BF00331314 http://dx.doi.org/10.1007/BF00331314 DOI 10.1016/0014-5793(94)80203-3 http://dx.doi.org/10.1016/0014-5793(94)80203-3 DOI 10.1016/0300-9084(89)90104-1 http://dx.doi.org/10.1016/0300-9084(89)90104-1 DOI 10.1016/S0969-2126(94)00100-6 http://dx.doi.org/10.1016/S0969-2126(94)00100-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1107/S0907444995007293 http://dx.doi.org/10.1107/S0907444995007293 DOI 10.1111/j.1365-2958.1993.tb01706.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb01706.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M16778 http://www.ebi.ac.uk/ena/data/view/M16778 EMBL S67014 http://www.ebi.ac.uk/ena/data/view/S67014 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X58872 http://www.ebi.ac.uk/ena/data/view/X58872 EMBL Z21843 http://www.ebi.ac.uk/ena/data/view/Z21843 EchoBASE EB0379 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0379 EcoGene EG10384 http://www.ecogene.org/geneInfo.php?eg_id=EG10384 EnsemblBacteria AAC75606 http://www.ensemblgenomes.org/id/AAC75606 EnsemblBacteria AAC75606 http://www.ensemblgenomes.org/id/AAC75606 EnsemblBacteria BAA16461 http://www.ensemblgenomes.org/id/BAA16461 EnsemblBacteria BAA16461 http://www.ensemblgenomes.org/id/BAA16461 EnsemblBacteria BAA16461 http://www.ensemblgenomes.org/id/BAA16461 EnsemblBacteria b2553 http://www.ensemblgenomes.org/id/b2553 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 GO_function GO:0036094 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036094 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0006808 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006808 GO_process GO:0042304 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042304 GO_process GO:0050790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050790 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.30.70.120 http://www.cathdb.info/version/latest/superfamily/3.30.70.120 GeneID 23339395 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23339395 GeneID 947016 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947016 HOGENOM HOG000017847 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000017847&db=HOGENOM6 InParanoid P0A9Z1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9Z1 IntAct P0A9Z1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9Z1* InterPro IPR002187 http://www.ebi.ac.uk/interpro/entry/IPR002187 InterPro IPR002332 http://www.ebi.ac.uk/interpro/entry/IPR002332 InterPro IPR011322 http://www.ebi.ac.uk/interpro/entry/IPR011322 InterPro IPR015867 http://www.ebi.ac.uk/interpro/entry/IPR015867 InterPro IPR017918 http://www.ebi.ac.uk/interpro/entry/IPR017918 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW2537 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2537 KEGG_Gene eco:b2553 http://www.genome.jp/dbget-bin/www_bget?eco:b2553 KEGG_Orthology KO:K04751 http://www.genome.jp/dbget-bin/www_bget?KO:K04751 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 MINT MINT-1235669 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1235669 OMA KIMLEIV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KIMLEIV PDB 1PIL http://www.ebi.ac.uk/pdbe-srv/view/entry/1PIL PDB 2PII http://www.ebi.ac.uk/pdbe-srv/view/entry/2PII PDBsum 1PIL http://www.ebi.ac.uk/pdbsum/1PIL PDBsum 2PII http://www.ebi.ac.uk/pdbsum/2PII PRINTS PR00340 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00340 PROSITE PS00496 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00496 PROSITE PS00638 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00638 PROSITE PS51343 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51343 PSORT swissprot:GLNB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLNB_ECOLI PSORT-B swissprot:GLNB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLNB_ECOLI PSORT2 swissprot:GLNB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLNB_ECOLI Pfam PF00543 http://pfam.xfam.org/family/PF00543 Phobius swissprot:GLNB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLNB_ECOLI PhylomeDB P0A9Z1 http://phylomedb.org/?seqid=P0A9Z1 ProteinModelPortal P0A9Z1 http://www.proteinmodelportal.org/query/uniprot/P0A9Z1 PubMed 15299730 http://www.ncbi.nlm.nih.gov/pubmed/15299730 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2034230 http://www.ncbi.nlm.nih.gov/pubmed/2034230 PubMed 2574599 http://www.ncbi.nlm.nih.gov/pubmed/2574599 PubMed 2885322 http://www.ncbi.nlm.nih.gov/pubmed/2885322 PubMed 2907369 http://www.ncbi.nlm.nih.gov/pubmed/2907369 PubMed 7866749 http://www.ncbi.nlm.nih.gov/pubmed/7866749 PubMed 8226691 http://www.ncbi.nlm.nih.gov/pubmed/8226691 PubMed 8293810 http://www.ncbi.nlm.nih.gov/pubmed/8293810 PubMed 8412694 http://www.ncbi.nlm.nih.gov/pubmed/8412694 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417048 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417048 RefSeq WP_000717694 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000717694 SMART SM00938 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00938 SMR P0A9Z1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9Z1 STRING 511145.b2553 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2553&targetmode=cogs STRING COG0347 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0347&targetmode=cogs SUPFAM SSF54913 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54913 UniProtKB GLNB_ECOLI http://www.uniprot.org/uniprot/GLNB_ECOLI UniProtKB-AC P0A9Z1 http://www.uniprot.org/uniprot/P0A9Z1 charge swissprot:GLNB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLNB_ECOLI eggNOG COG0347 http://eggnogapi.embl.de/nog_data/html/tree/COG0347 epestfind swissprot:GLNB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLNB_ECOLI garnier swissprot:GLNB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLNB_ECOLI helixturnhelix swissprot:GLNB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLNB_ECOLI hmoment swissprot:GLNB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLNB_ECOLI iep swissprot:GLNB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLNB_ECOLI inforesidue swissprot:GLNB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLNB_ECOLI octanol swissprot:GLNB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLNB_ECOLI pepcoil swissprot:GLNB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLNB_ECOLI pepdigest swissprot:GLNB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLNB_ECOLI pepinfo swissprot:GLNB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLNB_ECOLI pepnet swissprot:GLNB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLNB_ECOLI pepstats swissprot:GLNB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLNB_ECOLI pepwheel swissprot:GLNB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLNB_ECOLI pepwindow swissprot:GLNB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLNB_ECOLI sigcleave swissprot:GLNB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLNB_ECOLI ## Database ID URL or Descriptions # AltName GTP-binding protein Obg {ECO:0000255|HAMAP-Rule MF_01454} # BIOPHYSICOCHEMICAL PROPERTIES OBG_ECOLI Kinetic parameters KM=18 uM for GTP (at 37 degrees Celsius {ECO 0000269|PubMed 11976298, ECO 0000269|PubMed 15292126}; KM=7.9 uM for GTP (at 30 degrees Celsius {ECO 0000269|PubMed 11976298, ECO 0000269|PubMed 15292126}; Note=Turnover number of 0.02/min.; # BioGrid 4261647 134 # COFACTOR OBG_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_01454, ECO 0000305|PubMed 11555285}; # DISRUPTION PHENOTYPE Essential for growth, it cannot be disrupted. {ECO:0000269|PubMed 9743119}. # DOMAIN OBG_ECOLI The C-terminus (residues 341-390) is not required for either 50S ribosome subunit association nor 70S ribosome dissociation. {ECO 0000269|PubMed 24844575}. # EcoGene EG12795 obgE # FUNCTION OBG_ECOLI An abundant, essential GTPase which binds GTP, GDP and ppGpp with moderate affinity. Has high guanosine nucleotide exchange rate constants for GTP and GDP, and a relatively low GTP hydrolysis rate stimulated by the 50S ribosomal subunit. It is estimated there are 34000 molecules in log-phase cells and 5600 molecules in stationary-phase cells. Required for chromosome segregation. Plays a role in the stringent response, perhaps by sequestering 50S ribosomal subunits and decreasing protein synthesis (PubMed 19555460), and a non-essential role in the late steps of ribosome biogenesis, perhaps acting as a checkpoint for correct 50S subunit synthesis (Probable) (PubMed 24844575). Overexpression increases bacterial persistence (in exponential and stationary phase) in response to antibiotics (PubMed 26051177). Cells expressing high levels of Obg are more likely to form persister cells upon antibiotic exposure; this requires alarmone (p)ppGpp and acts via induced HokB, depolarizing cells, which probably reduces metabolic activity and induces persistence (PubMed 26051177). The persister phenotype can be separated from the essential phenotype (PubMed 26051177). {ECO 0000269|PubMed 11555285, ECO 0000269|PubMed 11976298, ECO 0000269|PubMed 12402086, ECO 0000269|PubMed 15836769, ECO 0000269|PubMed 16980477, ECO 0000269|PubMed 17578452, ECO 0000269|PubMed 17616600, ECO 0000269|PubMed 19555460, ECO 0000269|PubMed 26051177, ECO 0000305|PubMed 24844575}. # FUNCTION OBG_ECOLI Binds to pre-50S ribosomal subunits in a salt-dependent manner. Acts as a ribosome anti-association factor; guanosine nucleotides stimulate ObgE 50S subunit binding and also ObgE- mediated 70S ribosome dissocation (GDP3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3092 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3092 EcoGene EG13308 http://www.ecogene.org/geneInfo.php?eg_id=EG13308 EnsemblBacteria AAC73807 http://www.ensemblgenomes.org/id/AAC73807 EnsemblBacteria AAC73807 http://www.ensemblgenomes.org/id/AAC73807 EnsemblBacteria BAA35377 http://www.ensemblgenomes.org/id/BAA35377 EnsemblBacteria BAA35377 http://www.ensemblgenomes.org/id/BAA35377 EnsemblBacteria BAA35377 http://www.ensemblgenomes.org/id/BAA35377 EnsemblBacteria b0713 http://www.ensemblgenomes.org/id/b0713 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003824 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003824 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GeneID 945318 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945318 HAMAP MF_00691 http://hamap.expasy.org/unirule/MF_00691 HOGENOM HOG000237330 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000237330&db=HOGENOM6 InParanoid P75746 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75746 IntAct P75746 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75746* InterPro IPR005501 http://www.ebi.ac.uk/interpro/entry/IPR005501 InterPro IPR011330 http://www.ebi.ac.uk/interpro/entry/IPR011330 KEGG_Gene ecj:JW0703 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0703 KEGG_Gene eco:b0713 http://www.genome.jp/dbget-bin/www_bget?eco:b0713 KEGG_Orthology KO:K07160 http://www.genome.jp/dbget-bin/www_bget?KO:K07160 OMA AQVGYRD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AQVGYRD PDB 1XW8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1XW8 PDBsum 1XW8 http://www.ebi.ac.uk/pdbsum/1XW8 PSORT swissprot:YBGL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBGL_ECOLI PSORT-B swissprot:YBGL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBGL_ECOLI PSORT2 swissprot:YBGL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBGL_ECOLI Pfam PF03746 http://pfam.xfam.org/family/PF03746 Phobius swissprot:YBGL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBGL_ECOLI PhylomeDB P75746 http://phylomedb.org/?seqid=P75746 ProteinModelPortal P75746 http://www.proteinmodelportal.org/query/uniprot/P75746 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415241 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415241 RefSeq WP_000687112 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000687112 SMR P75746 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75746 STRING 511145.b0713 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0713&targetmode=cogs STRING COG1540 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1540&targetmode=cogs SUPFAM SSF88713 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF88713 UniProtKB YBGL_ECOLI http://www.uniprot.org/uniprot/YBGL_ECOLI UniProtKB-AC P75746 http://www.uniprot.org/uniprot/P75746 charge swissprot:YBGL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBGL_ECOLI eggNOG COG1540 http://eggnogapi.embl.de/nog_data/html/tree/COG1540 eggNOG ENOG4105E7W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E7W epestfind swissprot:YBGL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBGL_ECOLI garnier swissprot:YBGL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBGL_ECOLI helixturnhelix swissprot:YBGL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBGL_ECOLI hmoment swissprot:YBGL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBGL_ECOLI iep swissprot:YBGL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBGL_ECOLI inforesidue swissprot:YBGL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBGL_ECOLI octanol swissprot:YBGL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBGL_ECOLI pepcoil swissprot:YBGL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBGL_ECOLI pepdigest swissprot:YBGL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBGL_ECOLI pepinfo swissprot:YBGL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBGL_ECOLI pepnet swissprot:YBGL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBGL_ECOLI pepstats swissprot:YBGL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBGL_ECOLI pepwheel swissprot:YBGL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBGL_ECOLI pepwindow swissprot:YBGL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBGL_ECOLI sigcleave swissprot:YBGL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBGL_ECOLI ## Database ID URL or Descriptions # BioGrid 4259677 196 # EcoGene EG12651 wcaM # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0045228 slime layer polysaccharide biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 2.160.20.10 -; 1. # IntAct P71244 4 # InterPro IPR011050 Pectin_lyase_fold/virulence # InterPro IPR012334 Pectin_lyas_fold # InterPro IPR023882 Colanic_acid_synth_WcaM # Organism WCAM_ECOLI Escherichia coli (strain K12) # PATHWAY WCAM_ECOLI Slime biogenesis; slime polysaccharide biosynthesis. # PATRIC 32119419 VBIEscCol129921_2120 # PIR B64970 B64970 # PTM WCAM_ECOLI Exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven. # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName WCAM_ECOLI Colanic acid biosynthesis protein WcaM # RefSeq NP_416547 NC_000913.3 # RefSeq WP_001116026 NZ_LN832404.1 # SUPFAM SSF51126 SSF51126 # TIGRFAMs TIGR04004 WcaM # eggNOG ENOG4105G1A Bacteria # eggNOG ENOG4110WUJ LUCA BLAST swissprot:WCAM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:WCAM_ECOLI BioCyc ECOL316407:JW2028-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2028-MONOMER BioCyc EcoCyc:G7094-MONOMER http://biocyc.org/getid?id=EcoCyc:G7094-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M610507200 http://dx.doi.org/10.1074/jbc.M610507200 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U38473 http://www.ebi.ac.uk/ena/data/view/U38473 EchoBASE EB2521 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2521 EcoGene EG12651 http://www.ecogene.org/geneInfo.php?eg_id=EG12651 EnsemblBacteria AAC75104 http://www.ensemblgenomes.org/id/AAC75104 EnsemblBacteria AAC75104 http://www.ensemblgenomes.org/id/AAC75104 EnsemblBacteria BAA15897 http://www.ensemblgenomes.org/id/BAA15897 EnsemblBacteria BAA15897 http://www.ensemblgenomes.org/id/BAA15897 EnsemblBacteria BAA15897 http://www.ensemblgenomes.org/id/BAA15897 EnsemblBacteria b2043 http://www.ensemblgenomes.org/id/b2043 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GO_process GO:0045228 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045228 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 2.160.20.10 http://www.cathdb.info/version/latest/superfamily/2.160.20.10 GeneID 946561 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946561 HOGENOM HOG000121919 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000121919&db=HOGENOM6 IntAct P71244 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P71244* InterPro IPR011050 http://www.ebi.ac.uk/interpro/entry/IPR011050 InterPro IPR012334 http://www.ebi.ac.uk/interpro/entry/IPR012334 InterPro IPR023882 http://www.ebi.ac.uk/interpro/entry/IPR023882 KEGG_Gene ecj:JW2028 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2028 KEGG_Gene eco:b2043 http://www.genome.jp/dbget-bin/www_bget?eco:b2043 KEGG_Orthology KO:K16711 http://www.genome.jp/dbget-bin/www_bget?KO:K16711 OMA VRGKFMA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VRGKFMA PSORT swissprot:WCAM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:WCAM_ECOLI PSORT-B swissprot:WCAM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:WCAM_ECOLI PSORT2 swissprot:WCAM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:WCAM_ECOLI Phobius swissprot:WCAM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:WCAM_ECOLI ProteinModelPortal P71244 http://www.proteinmodelportal.org/query/uniprot/P71244 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17218314 http://www.ncbi.nlm.nih.gov/pubmed/17218314 PubMed 8759852 http://www.ncbi.nlm.nih.gov/pubmed/8759852 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416547 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416547 RefSeq WP_001116026 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001116026 STRING 511145.b2043 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2043&targetmode=cogs SUPFAM SSF51126 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51126 TIGRFAMs TIGR04004 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR04004 UniProtKB WCAM_ECOLI http://www.uniprot.org/uniprot/WCAM_ECOLI UniProtKB-AC P71244 http://www.uniprot.org/uniprot/P71244 charge swissprot:WCAM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:WCAM_ECOLI eggNOG ENOG4105G1A http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105G1A eggNOG ENOG4110WUJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4110WUJ epestfind swissprot:WCAM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:WCAM_ECOLI garnier swissprot:WCAM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:WCAM_ECOLI helixturnhelix swissprot:WCAM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:WCAM_ECOLI hmoment swissprot:WCAM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:WCAM_ECOLI iep swissprot:WCAM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:WCAM_ECOLI inforesidue swissprot:WCAM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:WCAM_ECOLI octanol swissprot:WCAM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:WCAM_ECOLI pepcoil swissprot:WCAM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:WCAM_ECOLI pepdigest swissprot:WCAM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:WCAM_ECOLI pepinfo swissprot:WCAM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:WCAM_ECOLI pepnet swissprot:WCAM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:WCAM_ECOLI pepstats swissprot:WCAM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:WCAM_ECOLI pepwheel swissprot:WCAM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:WCAM_ECOLI pepwindow swissprot:WCAM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:WCAM_ECOLI sigcleave swissprot:WCAM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:WCAM_ECOLI ## Database ID URL or Descriptions # AltName MOAC_ECOLI Molybdenum cofactor biosynthesis protein C # BioGrid 4262176 8 # CDD cd01420 MoaC_PE # EcoGene EG11666 moaC # FUNCTION MOAC_ECOLI Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z). # GO_process GO:0006777 Mo-molybdopterin cofactor biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0032324 molybdopterin cofactor biosynthetic process; IBA:GO_Central. # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.30.70.640 -; 1. # HAMAP MF_01224_B MoaC_B # INDUCTION MOAC_ECOLI By anaerobiosis, repressed by the molybdenum cofactor. # IntAct P0A738 20 # InterPro IPR002820 Mopterin_CF_biosynth-C_dom # InterPro IPR023045 Mo_CF_biosynth-C # InterPro IPR023046 Mo_CF_biosynth-C_bac # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko00790 Folate biosynthesis # KEGG_Pathway ko04122 Sulfur relay system # Organism MOAC_ECOLI Escherichia coli (strain K12) # PATHWAY MOAC_ECOLI Cofactor biosynthesis; molybdopterin biosynthesis. # PATRIC 32116767 VBIEscCol129921_0809 # PDB 1EKR X-ray; 2.00 A; A=1-161 # PDB 1EKS X-ray; 2.50 A; A=1-161 # PDB 4PYA X-ray; 1.79 A; A=3-161 # PDB 4PYD X-ray; 3.19 A; A/B/C/D/E/F=1-161 # PIR G64814 G64814 # Pfam PF01967 MoaC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MOAC_ECOLI Cyclic pyranopterin monophosphate synthase accessory protein # RefSeq NP_415304 NC_000913.3 # RefSeq WP_000080885 NZ_LN832404.1 # SIMILARITY Belongs to the MoaC family. {ECO 0000305}. # SUBUNIT MOAC_ECOLI Homohexamer. # SUPFAM SSF55040 SSF55040 # TIGRFAMs TIGR00581 moaC # eggNOG COG0315 LUCA # eggNOG ENOG4108YXW Bacteria BLAST swissprot:MOAC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MOAC_ECOLI BioCyc ECOL316407:JW0766-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0766-MONOMER BioCyc EcoCyc:EG11666-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11666-MONOMER BioCyc MetaCyc:EG11666-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11666-MONOMER COG COG0315 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0315 DIP DIP-10230N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10230N DOI 10.1016/S0969-2126(00)00157-X http://dx.doi.org/10.1016/S0969-2126(00)00157-X DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1993.tb01652.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb01652.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X70420 http://www.ebi.ac.uk/ena/data/view/X70420 EchoBASE EB1617 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1617 EcoGene EG11666 http://www.ecogene.org/geneInfo.php?eg_id=EG11666 EnsemblBacteria AAC73870 http://www.ensemblgenomes.org/id/AAC73870 EnsemblBacteria AAC73870 http://www.ensemblgenomes.org/id/AAC73870 EnsemblBacteria BAA35441 http://www.ensemblgenomes.org/id/BAA35441 EnsemblBacteria BAA35441 http://www.ensemblgenomes.org/id/BAA35441 EnsemblBacteria BAA35441 http://www.ensemblgenomes.org/id/BAA35441 EnsemblBacteria b0783 http://www.ensemblgenomes.org/id/b0783 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006777 GO_process GO:0032324 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032324 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.30.70.640 http://www.cathdb.info/version/latest/superfamily/3.30.70.640 GeneID 945397 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945397 HAMAP MF_01224_B http://hamap.expasy.org/unirule/MF_01224_B HOGENOM HOG000228417 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000228417&db=HOGENOM6 InParanoid P0A738 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A738 IntAct P0A738 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A738* InterPro IPR002820 http://www.ebi.ac.uk/interpro/entry/IPR002820 InterPro IPR023045 http://www.ebi.ac.uk/interpro/entry/IPR023045 InterPro IPR023046 http://www.ebi.ac.uk/interpro/entry/IPR023046 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW0766 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0766 KEGG_Gene eco:b0783 http://www.genome.jp/dbget-bin/www_bget?eco:b0783 KEGG_Orthology KO:K03637 http://www.genome.jp/dbget-bin/www_bget?KO:K03637 KEGG_Pathway ko00790 http://www.genome.jp/kegg-bin/show_pathway?ko00790 KEGG_Pathway ko04122 http://www.genome.jp/kegg-bin/show_pathway?ko04122 KEGG_Reaction rn:R09394 http://www.genome.jp/dbget-bin/www_bget?rn:R09394 MINT MINT-1231800 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1231800 OMA WIPMCHP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WIPMCHP PDB 1EKR http://www.ebi.ac.uk/pdbe-srv/view/entry/1EKR PDB 1EKS http://www.ebi.ac.uk/pdbe-srv/view/entry/1EKS PDB 4PYA http://www.ebi.ac.uk/pdbe-srv/view/entry/4PYA PDB 4PYD http://www.ebi.ac.uk/pdbe-srv/view/entry/4PYD PDBsum 1EKR http://www.ebi.ac.uk/pdbsum/1EKR PDBsum 1EKS http://www.ebi.ac.uk/pdbsum/1EKS PDBsum 4PYA http://www.ebi.ac.uk/pdbsum/4PYA PDBsum 4PYD http://www.ebi.ac.uk/pdbsum/4PYD PSORT swissprot:MOAC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MOAC_ECOLI PSORT-B swissprot:MOAC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MOAC_ECOLI PSORT2 swissprot:MOAC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MOAC_ECOLI Pfam PF01967 http://pfam.xfam.org/family/PF01967 Phobius swissprot:MOAC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MOAC_ECOLI PhylomeDB P0A738 http://phylomedb.org/?seqid=P0A738 ProteinModelPortal P0A738 http://www.proteinmodelportal.org/query/uniprot/P0A738 PubMed 10903949 http://www.ncbi.nlm.nih.gov/pubmed/10903949 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8361352 http://www.ncbi.nlm.nih.gov/pubmed/8361352 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415304 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415304 RefSeq WP_000080885 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000080885 SMR P0A738 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A738 STRING 511145.b0783 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0783&targetmode=cogs STRING COG0315 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0315&targetmode=cogs SUPFAM SSF55040 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55040 TIGRFAMs TIGR00581 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00581 UniProtKB MOAC_ECOLI http://www.uniprot.org/uniprot/MOAC_ECOLI UniProtKB-AC P0A738 http://www.uniprot.org/uniprot/P0A738 charge swissprot:MOAC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MOAC_ECOLI eggNOG COG0315 http://eggnogapi.embl.de/nog_data/html/tree/COG0315 eggNOG ENOG4108YXW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108YXW epestfind swissprot:MOAC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MOAC_ECOLI garnier swissprot:MOAC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MOAC_ECOLI helixturnhelix swissprot:MOAC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MOAC_ECOLI hmoment swissprot:MOAC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MOAC_ECOLI iep swissprot:MOAC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MOAC_ECOLI inforesidue swissprot:MOAC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MOAC_ECOLI octanol swissprot:MOAC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MOAC_ECOLI pepcoil swissprot:MOAC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MOAC_ECOLI pepdigest swissprot:MOAC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MOAC_ECOLI pepinfo swissprot:MOAC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MOAC_ECOLI pepnet swissprot:MOAC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MOAC_ECOLI pepstats swissprot:MOAC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MOAC_ECOLI pepwheel swissprot:MOAC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MOAC_ECOLI pepwindow swissprot:MOAC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MOAC_ECOLI sigcleave swissprot:MOAC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MOAC_ECOLI ## Database ID URL or Descriptions # AltName GTRA_ECOLI Bactoprenol-linked glucose translocase homolog from prophage CPS-53 # BioGrid 4260541 149 # EcoGene EG14131 yfdG # FUNCTION GTRA_ECOLI Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity). {ECO 0000250}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0003824 catalytic activity; IDA:EcoliWiki. # GO_function GO:0003870 5-aminolevulinate synthase activity; IMP:EcoliWiki. # GO_function GO:0008883 glutamyl-tRNA reductase activity; IDA:EcoliWiki. # GO_function GO:0050661 NADP binding; IDA:EcoliWiki. # GO_process GO:0000271 polysaccharide biosynthetic process; IEA:InterPro. # GO_process GO:0006783 heme biosynthetic process; IMP:EcoliWiki. # GO_process GO:0006810 transport; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006810 transport # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0051186 cofactor metabolic process # InterPro IPR007267 GtrA # InterPro IPR016480 Glc_translocase_bactprenl-link # Organism GTRA_ECOLI Escherichia coli (strain K12) # PIR C65008 C65008 # PIRSF PIRSF006298 GtrA_prd # Pfam PF04138 GtrA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Prophage bactoprenol-linked glucose translocase homolog {ECO 0000305} # RefSeq NP_416851 NC_000913.3 # RefSeq WP_000915541 NZ_LN832404.1 # SIMILARITY Belongs to the GtrA family. {ECO 0000305}. # SUBCELLULAR LOCATION GTRA_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG COG2246 LUCA # eggNOG ENOG4105IHM Bacteria BLAST swissprot:GTRA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GTRA_ECOLI BioCyc ECOL316407:JW2346-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2346-MONOMER BioCyc EcoCyc:G7219-MONOMER http://biocyc.org/getid?id=EcoCyc:G7219-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3883 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3883 EcoGene EG14131 http://www.ecogene.org/geneInfo.php?eg_id=EG14131 EnsemblBacteria AAC75409 http://www.ensemblgenomes.org/id/AAC75409 EnsemblBacteria AAC75409 http://www.ensemblgenomes.org/id/AAC75409 EnsemblBacteria BAA16209 http://www.ensemblgenomes.org/id/BAA16209 EnsemblBacteria BAA16209 http://www.ensemblgenomes.org/id/BAA16209 EnsemblBacteria BAA16209 http://www.ensemblgenomes.org/id/BAA16209 EnsemblBacteria b2350 http://www.ensemblgenomes.org/id/b2350 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0003824 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003824 GO_function GO:0003870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003870 GO_function GO:0008883 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008883 GO_function GO:0050661 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050661 GO_process GO:0000271 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000271 GO_process GO:0006783 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006783 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GeneID 948821 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948821 HOGENOM HOG000005085 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000005085&db=HOGENOM6 InterPro IPR007267 http://www.ebi.ac.uk/interpro/entry/IPR007267 InterPro IPR016480 http://www.ebi.ac.uk/interpro/entry/IPR016480 KEGG_Gene ecj:JW2346 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2346 KEGG_Gene eco:b2350 http://www.genome.jp/dbget-bin/www_bget?eco:b2350 OMA STTAMRY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=STTAMRY PSORT swissprot:GTRA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GTRA_ECOLI PSORT-B swissprot:GTRA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GTRA_ECOLI PSORT2 swissprot:GTRA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GTRA_ECOLI Pfam PF04138 http://pfam.xfam.org/family/PF04138 Phobius swissprot:GTRA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GTRA_ECOLI ProteinModelPortal P77682 http://www.proteinmodelportal.org/query/uniprot/P77682 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416851 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416851 RefSeq WP_000915541 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000915541 STRING 511145.b2350 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2350&targetmode=cogs UniProtKB GTRA_ECOLI http://www.uniprot.org/uniprot/GTRA_ECOLI UniProtKB-AC P77682 http://www.uniprot.org/uniprot/P77682 charge swissprot:GTRA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GTRA_ECOLI eggNOG COG2246 http://eggnogapi.embl.de/nog_data/html/tree/COG2246 eggNOG ENOG4105IHM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105IHM epestfind swissprot:GTRA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GTRA_ECOLI garnier swissprot:GTRA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GTRA_ECOLI helixturnhelix swissprot:GTRA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GTRA_ECOLI hmoment swissprot:GTRA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GTRA_ECOLI iep swissprot:GTRA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GTRA_ECOLI inforesidue swissprot:GTRA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GTRA_ECOLI octanol swissprot:GTRA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GTRA_ECOLI pepcoil swissprot:GTRA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GTRA_ECOLI pepdigest swissprot:GTRA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GTRA_ECOLI pepinfo swissprot:GTRA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GTRA_ECOLI pepnet swissprot:GTRA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GTRA_ECOLI pepstats swissprot:GTRA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GTRA_ECOLI pepwheel swissprot:GTRA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GTRA_ECOLI pepwindow swissprot:GTRA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GTRA_ECOLI sigcleave swissprot:GTRA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GTRA_ECOLI ## Database ID URL or Descriptions # AltName RCLC_ECOLI Reactive chlorine resistance protein C # BioGrid 4259798 5 # DISRUPTION PHENOTYPE Mutants are more sensitive to HOCl treatment than wild-type cells. {ECO:0000269|PubMed 24078635}. # EcoGene EG13579 rclC # FUNCTION RCLC_ECOLI Probably involved in reactive chlorine species (RCS) stress resistance. {ECO 0000269|PubMed 24078635}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:1901530 response to hypochlorite; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006950 response to stress # INDUCTION Induced by RclR in response to hypochlorous acid (HOCl). {ECO:0000269|PubMed 24078635}. # InterPro IPR007339 DUF417 # Organism RCLC_ECOLI Escherichia coli (strain K12) # PATRIC 32115733 VBIEscCol129921_0309 # PIR E64756 E64756 # Pfam PF04224 DUF417 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RCLC_ECOLI Inner membrane protein RclC # RefSeq NP_414835 NC_000913.3 # RefSeq WP_001299021 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18029.1; Type=Frameshift; Positions=138; Evidence={ECO 0000305}; # SUBCELLULAR LOCATION RCLC_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # eggNOG COG3059 LUCA # eggNOG ENOG4108KBJ Bacteria BLAST swissprot:RCLC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RCLC_ECOLI BioCyc ECOL316407:JW5038-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5038-MONOMER BioCyc EcoCyc:G6171-MONOMER http://biocyc.org/getid?id=EcoCyc:G6171-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M113.503516 http://dx.doi.org/10.1074/jbc.M113.503516 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB3349 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3349 EcoGene EG13579 http://www.ecogene.org/geneInfo.php?eg_id=EG13579 EnsemblBacteria AAC73404 http://www.ensemblgenomes.org/id/AAC73404 EnsemblBacteria AAC73404 http://www.ensemblgenomes.org/id/AAC73404 EnsemblBacteria BAE76086 http://www.ensemblgenomes.org/id/BAE76086 EnsemblBacteria BAE76086 http://www.ensemblgenomes.org/id/BAE76086 EnsemblBacteria BAE76086 http://www.ensemblgenomes.org/id/BAE76086 EnsemblBacteria b0301 http://www.ensemblgenomes.org/id/b0301 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:1901530 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901530 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 944974 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944974 HOGENOM HOG000282453 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000282453&db=HOGENOM6 InParanoid P75685 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75685 InterPro IPR007339 http://www.ebi.ac.uk/interpro/entry/IPR007339 KEGG_Gene ecj:JW5038 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5038 KEGG_Gene eco:b0301 http://www.genome.jp/dbget-bin/www_bget?eco:b0301 OMA TTPEVYV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TTPEVYV PSORT swissprot:RCLC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RCLC_ECOLI PSORT-B swissprot:RCLC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RCLC_ECOLI PSORT2 swissprot:RCLC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RCLC_ECOLI Pfam PF04224 http://pfam.xfam.org/family/PF04224 Phobius swissprot:RCLC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RCLC_ECOLI PhylomeDB P75685 http://phylomedb.org/?seqid=P75685 ProteinModelPortal P75685 http://www.proteinmodelportal.org/query/uniprot/P75685 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 24078635 http://www.ncbi.nlm.nih.gov/pubmed/24078635 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414835 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414835 RefSeq WP_001299021 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001299021 STRING 511145.b0301 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0301&targetmode=cogs UniProtKB RCLC_ECOLI http://www.uniprot.org/uniprot/RCLC_ECOLI UniProtKB-AC P75685 http://www.uniprot.org/uniprot/P75685 charge swissprot:RCLC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RCLC_ECOLI eggNOG COG3059 http://eggnogapi.embl.de/nog_data/html/tree/COG3059 eggNOG ENOG4108KBJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108KBJ epestfind swissprot:RCLC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RCLC_ECOLI garnier swissprot:RCLC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RCLC_ECOLI helixturnhelix swissprot:RCLC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RCLC_ECOLI hmoment swissprot:RCLC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RCLC_ECOLI iep swissprot:RCLC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RCLC_ECOLI inforesidue swissprot:RCLC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RCLC_ECOLI octanol swissprot:RCLC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RCLC_ECOLI pepcoil swissprot:RCLC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RCLC_ECOLI pepdigest swissprot:RCLC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RCLC_ECOLI pepinfo swissprot:RCLC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RCLC_ECOLI pepnet swissprot:RCLC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RCLC_ECOLI pepstats swissprot:RCLC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RCLC_ECOLI pepwheel swissprot:RCLC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RCLC_ECOLI pepwindow swissprot:RCLC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RCLC_ECOLI sigcleave swissprot:RCLC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RCLC_ECOLI ## Database ID URL or Descriptions # BioGrid 4260311 186 # EcoGene EG13492 mipA # FUNCTION MIPA_ECOLI May serve as a scaffold protein required for the formation of a complex with MrcB/PonB and MltA, this complex could play a role in enlargement and septation of the murein sacculus. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_function GO:0030674 protein binding, bridging; IPI:EcoCyc. # GO_process GO:0009252 peptidoglycan biosynthetic process; IPI:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0030674 protein binding, bridging # GOslim_process GO:0009058 biosynthetic process # IntAct P0A908 4 # InterPro IPR010583 MipA # Organism MIPA_ECOLI Escherichia coli (strain K12) # PATRIC 32118875 VBIEscCol129921_1855 # PIR F64938 F64938 # Pfam PF06629 MipA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MIPA_ECOLI MltA-interacting protein # RefSeq NP_416296 NC_000913.3 # RefSeq WP_000163771 NZ_LN832404.1 # SIMILARITY Belongs to the MipA/OmpV family. {ECO 0000305}. # SUBCELLULAR LOCATION MIPA_ECOLI Cell outer membrane {ECO 0000269|PubMed 16079137}. # SUBUNIT MIPA_ECOLI Forms a trimeric complex with MrcB and MltA in vitro. # TCDB 9.B.99.1 the mipa-interacting protein (mipa) family # eggNOG COG3713 LUCA # eggNOG ENOG4105GNX Bacteria BLAST swissprot:MIPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MIPA_ECOLI BioCyc ECOL316407:JW1771-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1771-MONOMER BioCyc EcoCyc:G6968-MONOMER http://biocyc.org/getid?id=EcoCyc:G6968-MONOMER BioCyc MetaCyc:G6968-MONOMER http://biocyc.org/getid?id=MetaCyc:G6968-MONOMER COG COG3713 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3713 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1432-1327.2000.01296.x http://dx.doi.org/10.1046/j.1432-1327.2000.01296.x DOI 10.1074/jbc.274.10.6726 http://dx.doi.org/10.1074/jbc.274.10.6726 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3265 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3265 EcoGene EG13492 http://www.ecogene.org/geneInfo.php?eg_id=EG13492 EnsemblBacteria AAC74852 http://www.ensemblgenomes.org/id/AAC74852 EnsemblBacteria AAC74852 http://www.ensemblgenomes.org/id/AAC74852 EnsemblBacteria BAA15579 http://www.ensemblgenomes.org/id/BAA15579 EnsemblBacteria BAA15579 http://www.ensemblgenomes.org/id/BAA15579 EnsemblBacteria BAA15579 http://www.ensemblgenomes.org/id/BAA15579 EnsemblBacteria b1782 http://www.ensemblgenomes.org/id/b1782 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_function GO:0030674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030674 GO_process GO:0009252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009252 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0030674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030674 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 946301 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946301 HOGENOM HOG000121141 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000121141&db=HOGENOM6 InParanoid P0A908 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A908 IntAct P0A908 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A908* InterPro IPR010583 http://www.ebi.ac.uk/interpro/entry/IPR010583 KEGG_Gene ecj:JW1771 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1771 KEGG_Gene eco:b1782 http://www.genome.jp/dbget-bin/www_bget?eco:b1782 KEGG_Orthology KO:K07274 http://www.genome.jp/dbget-bin/www_bget?KO:K07274 OMA LSIMAYY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LSIMAYY PSORT swissprot:MIPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MIPA_ECOLI PSORT-B swissprot:MIPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MIPA_ECOLI PSORT2 swissprot:MIPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MIPA_ECOLI Pfam PF06629 http://pfam.xfam.org/family/PF06629 Phobius swissprot:MIPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MIPA_ECOLI PhylomeDB P0A908 http://phylomedb.org/?seqid=P0A908 ProteinModelPortal P0A908 http://www.proteinmodelportal.org/query/uniprot/P0A908 PubMed 10037771 http://www.ncbi.nlm.nih.gov/pubmed/10037771 PubMed 10806384 http://www.ncbi.nlm.nih.gov/pubmed/10806384 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416296 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416296 RefSeq WP_000163771 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000163771 STRING 511145.b1782 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1782&targetmode=cogs STRING COG3713 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3713&targetmode=cogs TCDB 9.B.99.1 http://www.tcdb.org/search/result.php?tc=9.B.99.1 UniProtKB MIPA_ECOLI http://www.uniprot.org/uniprot/MIPA_ECOLI UniProtKB-AC P0A908 http://www.uniprot.org/uniprot/P0A908 charge swissprot:MIPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MIPA_ECOLI eggNOG COG3713 http://eggnogapi.embl.de/nog_data/html/tree/COG3713 eggNOG ENOG4105GNX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105GNX epestfind swissprot:MIPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MIPA_ECOLI garnier swissprot:MIPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MIPA_ECOLI helixturnhelix swissprot:MIPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MIPA_ECOLI hmoment swissprot:MIPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MIPA_ECOLI iep swissprot:MIPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MIPA_ECOLI inforesidue swissprot:MIPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MIPA_ECOLI octanol swissprot:MIPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MIPA_ECOLI pepcoil swissprot:MIPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MIPA_ECOLI pepdigest swissprot:MIPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MIPA_ECOLI pepinfo swissprot:MIPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MIPA_ECOLI pepnet swissprot:MIPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MIPA_ECOLI pepstats swissprot:MIPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MIPA_ECOLI pepwheel swissprot:MIPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MIPA_ECOLI pepwindow swissprot:MIPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MIPA_ECOLI sigcleave swissprot:MIPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MIPA_ECOLI ## Database ID URL or Descriptions # AltName WCAJ_ECOLI Colanic acid biosynthesis UDP-glucose lipid carrier transferase # AltName WCAJ_ECOLI Glucosyl-P-P-undecaprenol synthase # BioGrid 4263311 180 # CATALYTIC ACTIVITY UDP-glucose + ditrans,octacis-undecaprenyl phosphate = UMP + alpha-D-glucopyranosyl-diphospho- ditrans,octacis-undecaprenol. {ECO:0000269|PubMed 22408159}. # DISRUPTION PHENOTYPE Cells lacking this gene show a non-mucoid phenotype. {ECO:0000269|PubMed 22408159}. # EcoGene EG13575 wcaJ # FUNCTION WCAJ_ECOLI Is the initiating enzyme for colanic acid (CA) synthesis. Catalyzes the transfer of the glucose-1-phosphate moiety from UDP-Glc onto the carrier lipid undecaprenyl phosphate (C55-P), forming a phosphoanhydride bond yielding to glucosyl- pyrophosphoryl-undecaprenol (Glc-PP-C55). Also possesses a weak galactose-1-P transferase activity. {ECO 0000269|PubMed 22408159}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0016757 transferase activity, transferring glycosyl groups; IEA:UniProtKB-KW. # GO_function GO:0089702 undecaprenyl-phosphate glucose phosphotransferase activity; IDA:EcoCyc. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0009242 colanic acid biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # InterPro IPR003362 Bact_transf # InterPro IPR017473 Undecaprenyl-P_gluc_Ptfrase # InterPro IPR017475 EPS_sugar_tfrase # MISCELLANEOUS Complements holdfast synthesis in the C.crescentus mutant lacking hfsE, pssY and pssZ genes. Can also partially complement the O-antigen defect in the S.typhimurium wbaP deletion strain (PubMed:22408159). {ECO 0000305|PubMed:22408159}. # Organism WCAJ_ECOLI Escherichia coli (strain K12) # PATHWAY Exopolysaccharide biosynthesis; colanic acid biosynthesis. {ECO:0000269|PubMed 22408159}. # PATRIC 32119427 VBIEscCol129921_2124 # PIR F64970 F64970 # Pfam PF02397 Bac_transf # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UDP-glucose undecaprenyl-phosphate glucose-1-phosphate transferase # RefSeq NP_416551 NC_000913.3 # RefSeq WP_000183107 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial sugar transferase family. {ECO 0000305}. # SUBCELLULAR LOCATION WCAJ_ECOLI Cell inner membrane {ECO 0000269|PubMed 22408159}; Multi-pass membrane protein {ECO 0000269|PubMed 22408159}. # TIGRFAMs TIGR03023 WcaJ_sugtrans # TIGRFAMs TIGR03025 EPS_sugtrans # eggNOG COG2148 LUCA # eggNOG ENOG4105D3Q Bacteria BLAST swissprot:WCAJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:WCAJ_ECOLI BioCyc ECOL316407:JW2032-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2032-MONOMER BioCyc EcoCyc:G7098-MONOMER http://biocyc.org/getid?id=EcoCyc:G7098-MONOMER BioCyc MetaCyc:G7098-MONOMER http://biocyc.org/getid?id=MetaCyc:G7098-MONOMER COG COG2148 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2148 DIP DIP-11125N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11125N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.06052-11 http://dx.doi.org/10.1128/JB.06052-11 EC_number EC:2.7.8.31 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.8.31 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U38473 http://www.ebi.ac.uk/ena/data/view/U38473 ENZYME 2.7.8.31 http://enzyme.expasy.org/EC/2.7.8.31 EchoBASE EB3345 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3345 EcoGene EG13575 http://www.ecogene.org/geneInfo.php?eg_id=EG13575 EnsemblBacteria AAC75108 http://www.ensemblgenomes.org/id/AAC75108 EnsemblBacteria AAC75108 http://www.ensemblgenomes.org/id/AAC75108 EnsemblBacteria BAA15900 http://www.ensemblgenomes.org/id/BAA15900 EnsemblBacteria BAA15900 http://www.ensemblgenomes.org/id/BAA15900 EnsemblBacteria BAA15900 http://www.ensemblgenomes.org/id/BAA15900 EnsemblBacteria b2047 http://www.ensemblgenomes.org/id/b2047 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GO_function GO:0089702 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0089702 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GO_process GO:0009242 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009242 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 946583 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946583 HOGENOM HOG000153662 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000153662&db=HOGENOM6 InParanoid P71241 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P71241 IntAct P71241 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P71241* IntEnz 2.7.8.31 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.8.31 InterPro IPR003362 http://www.ebi.ac.uk/interpro/entry/IPR003362 InterPro IPR017473 http://www.ebi.ac.uk/interpro/entry/IPR017473 InterPro IPR017475 http://www.ebi.ac.uk/interpro/entry/IPR017475 KEGG_Gene ecj:JW2032 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2032 KEGG_Gene eco:b2047 http://www.genome.jp/dbget-bin/www_bget?eco:b2047 KEGG_Orthology KO:K03606 http://www.genome.jp/dbget-bin/www_bget?KO:K03606 OMA DSFRKEP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DSFRKEP PSORT swissprot:WCAJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:WCAJ_ECOLI PSORT-B swissprot:WCAJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:WCAJ_ECOLI PSORT2 swissprot:WCAJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:WCAJ_ECOLI Pfam PF02397 http://pfam.xfam.org/family/PF02397 Phobius swissprot:WCAJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:WCAJ_ECOLI PhylomeDB P71241 http://phylomedb.org/?seqid=P71241 ProteinModelPortal P71241 http://www.proteinmodelportal.org/query/uniprot/P71241 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22408159 http://www.ncbi.nlm.nih.gov/pubmed/22408159 PubMed 8759852 http://www.ncbi.nlm.nih.gov/pubmed/8759852 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416551 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416551 RefSeq WP_000183107 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000183107 STRING 511145.b2047 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2047&targetmode=cogs STRING COG2148 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2148&targetmode=cogs TIGRFAMs TIGR03023 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03023 TIGRFAMs TIGR03025 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03025 UniProtKB WCAJ_ECOLI http://www.uniprot.org/uniprot/WCAJ_ECOLI UniProtKB-AC P71241 http://www.uniprot.org/uniprot/P71241 charge swissprot:WCAJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:WCAJ_ECOLI eggNOG COG2148 http://eggnogapi.embl.de/nog_data/html/tree/COG2148 eggNOG ENOG4105D3Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D3Q epestfind swissprot:WCAJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:WCAJ_ECOLI garnier swissprot:WCAJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:WCAJ_ECOLI helixturnhelix swissprot:WCAJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:WCAJ_ECOLI hmoment swissprot:WCAJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:WCAJ_ECOLI iep swissprot:WCAJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:WCAJ_ECOLI inforesidue swissprot:WCAJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:WCAJ_ECOLI octanol swissprot:WCAJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:WCAJ_ECOLI pepcoil swissprot:WCAJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:WCAJ_ECOLI pepdigest swissprot:WCAJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:WCAJ_ECOLI pepinfo swissprot:WCAJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:WCAJ_ECOLI pepnet swissprot:WCAJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:WCAJ_ECOLI pepstats swissprot:WCAJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:WCAJ_ECOLI pepwheel swissprot:WCAJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:WCAJ_ECOLI pepwindow swissprot:WCAJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:WCAJ_ECOLI sigcleave swissprot:WCAJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:WCAJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4261080 581 # CAUTION Was initially characterized with a propeptide of 20 residues; this is now thought to be the result of in vitro proteolysis when the protein is overexpressed. {ECO:0000305|PubMed 12220175}. # CDD cd01854 YjeQ_EngC # COFACTOR RSGA_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000250}; Note=Binds 1 zinc ion per subunit. {ECO 0000250}; # DISRUPTION PHENOTYPE Reduced growth rate. The phenotype is partially suppressed by overexpression of a number of genes involved in ribosome function, including infB, era and ksgA. {ECO:0000269|PubMed 15466596}. # DOMAIN RSGA_ECOLI The knuckle-like cysteine cluster domain resembles the Zn- knuckle domain that is found in the nucleocapsid protein from HIV- 1 virus, suggesting that it may bind RNA. # EcoGene EG12479 rsgA # FUNCTION RSGA_ECOLI May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover. Dispensible for viability, but important for overall fitness. The intrinsic GTPase activity is stimulated by the presence of 30S (160-fold increase in kcat) or 70S (96 fold increase in kcat) ribosomes (PubMed 14973029). The GTPase is inhibited by aminoglycoside antibiotics such as neomycin and paromycin (PubMed 15466596) streptomycin and spectinomycin (PubMed 15828870). This inhibition is not due to competition for binding sites on the 30S or 70S ribosome (PubMed 15828870). {ECO 0000269|PubMed 12220175, ECO 0000269|PubMed 14973029, ECO 0000269|PubMed 15466596, ECO 0000269|PubMed 15828870}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003924 GTPase activity; IDA:EcoCyc. # GO_function GO:0005525 GTP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0019003 GDP binding; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0042274 ribosomal small subunit biogenesis; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003924 GTPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.300 -; 1. # HAMAP MF_01820 GTPase_RsgA # IntAct P39286 32 # InterPro IPR004881 Ribosome_biogen_GTPase_RsgA # InterPro IPR010914 RsgA_GTPase_dom # InterPro IPR027417 P-loop_NTPase # InterPro IPR030378 G_CP_dom # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # MASS SPECTROMETRY Mass=36830; Method=Electrospray; Range=21-350; Evidence={ECO:0000269|PubMed 12220175}; # Organism RSGA_ECOLI Escherichia coli (strain K12) # PATRIC 32123895 VBIEscCol129921_4295 # PDB 2YKR EM; 9.80 A; W=1-350 # PDB 4A2I EM; 16.50 A; V=35-337 # PIR S56389 S56389 # PROSITE PS50936 ENGC_GTPASE # PROSITE PS51721 G_CP # Pfam PF03193 DUF258 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RSGA_ECOLI Putative ribosome biogenesis GTPase RsgA # RefSeq NP_418585 NC_000913.3 # RefSeq WP_000041964 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97060.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. {ECO 0000305}. # SIMILARITY Contains 1 CP-type G (guanine nucleotide-binding) domain. {ECO 0000305}. # SUBUNIT Monomer (Probable). All of the protein is associated with ribosomes; the ratio is substoichiometric at 1:200 RsgA/ribosome. Association is tightest with the 30S subunit in the presence of the non-hydrolyzable GTP analog GMP-PNP. {ECO 0000305}. # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR00157 TIGR00157 # eggNOG COG1162 LUCA # eggNOG ENOG4105E06 Bacteria BLAST swissprot:RSGA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RSGA_ECOLI BioCyc ECOL316407:JW4122-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4122-MONOMER BioCyc EcoCyc:G7841-MONOMER http://biocyc.org/getid?id=EcoCyc:G7841-MONOMER BioCyc MetaCyc:G7841-MONOMER http://biocyc.org/getid?id=MetaCyc:G7841-MONOMER COG COG1162 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1162 DIP DIP-12581N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12581N DOI 10.1021/bi020355q http://dx.doi.org/10.1021/bi020355q DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nbt0998-851 http://dx.doi.org/10.1038/nbt0998-851 DOI 10.1042/BJ20041873 http://dx.doi.org/10.1042/BJ20041873 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1093/nar/gkh861 http://dx.doi.org/10.1093/nar/gkh861 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01744-07 http://dx.doi.org/10.1128/JB.01744-07 DOI 10.1128/JB.186.5.1381-1387.2004 http://dx.doi.org/10.1128/JB.186.5.1381-1387.2004 EC_number EC:3.6.1.- http://www.genome.jp/dbget-bin/www_bget?EC:3.6.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 3.6.1.- http://enzyme.expasy.org/EC/3.6.1.- EchoBASE EB2372 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2372 EcoGene EG12479 http://www.ecogene.org/geneInfo.php?eg_id=EG12479 EnsemblBacteria AAC77121 http://www.ensemblgenomes.org/id/AAC77121 EnsemblBacteria AAC77121 http://www.ensemblgenomes.org/id/AAC77121 EnsemblBacteria BAE78165 http://www.ensemblgenomes.org/id/BAE78165 EnsemblBacteria BAE78165 http://www.ensemblgenomes.org/id/BAE78165 EnsemblBacteria BAE78165 http://www.ensemblgenomes.org/id/BAE78165 EnsemblBacteria b4161 http://www.ensemblgenomes.org/id/b4161 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_function GO:0019003 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019003 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0042274 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042274 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948674 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948674 HAMAP MF_01820 http://hamap.expasy.org/unirule/MF_01820 HOGENOM HOG000006957 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006957&db=HOGENOM6 InParanoid P39286 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39286 IntAct P39286 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39286* IntEnz 3.6.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.1 InterPro IPR004881 http://www.ebi.ac.uk/interpro/entry/IPR004881 InterPro IPR010914 http://www.ebi.ac.uk/interpro/entry/IPR010914 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR030378 http://www.ebi.ac.uk/interpro/entry/IPR030378 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW4122 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4122 KEGG_Gene eco:b4161 http://www.genome.jp/dbget-bin/www_bget?eco:b4161 KEGG_Orthology KO:K06949 http://www.genome.jp/dbget-bin/www_bget?KO:K06949 MINT MINT-7290812 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-7290812 OMA THIIAAN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=THIIAAN PDB 2YKR http://www.ebi.ac.uk/pdbe-srv/view/entry/2YKR PDB 4A2I http://www.ebi.ac.uk/pdbe-srv/view/entry/4A2I PDBsum 2YKR http://www.ebi.ac.uk/pdbsum/2YKR PDBsum 4A2I http://www.ebi.ac.uk/pdbsum/4A2I PROSITE PS50936 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50936 PROSITE PS51721 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51721 PSORT swissprot:RSGA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RSGA_ECOLI PSORT-B swissprot:RSGA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RSGA_ECOLI PSORT2 swissprot:RSGA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RSGA_ECOLI Pfam PF03193 http://pfam.xfam.org/family/PF03193 Phobius swissprot:RSGA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RSGA_ECOLI PhylomeDB P39286 http://phylomedb.org/?seqid=P39286 ProteinModelPortal P39286 http://www.proteinmodelportal.org/query/uniprot/P39286 PubMed 12220175 http://www.ncbi.nlm.nih.gov/pubmed/12220175 PubMed 14973029 http://www.ncbi.nlm.nih.gov/pubmed/14973029 PubMed 15466596 http://www.ncbi.nlm.nih.gov/pubmed/15466596 PubMed 15828870 http://www.ncbi.nlm.nih.gov/pubmed/15828870 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18223068 http://www.ncbi.nlm.nih.gov/pubmed/18223068 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9743119 http://www.ncbi.nlm.nih.gov/pubmed/9743119 RefSeq NP_418585 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418585 RefSeq WP_000041964 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000041964 SMR P39286 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39286 STRING 511145.b4161 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4161&targetmode=cogs STRING COG1162 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1162&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR00157 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00157 UniProtKB RSGA_ECOLI http://www.uniprot.org/uniprot/RSGA_ECOLI UniProtKB-AC P39286 http://www.uniprot.org/uniprot/P39286 charge swissprot:RSGA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RSGA_ECOLI eggNOG COG1162 http://eggnogapi.embl.de/nog_data/html/tree/COG1162 eggNOG ENOG4105E06 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E06 epestfind swissprot:RSGA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RSGA_ECOLI garnier swissprot:RSGA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RSGA_ECOLI helixturnhelix swissprot:RSGA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RSGA_ECOLI hmoment swissprot:RSGA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RSGA_ECOLI iep swissprot:RSGA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RSGA_ECOLI inforesidue swissprot:RSGA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RSGA_ECOLI octanol swissprot:RSGA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RSGA_ECOLI pepcoil swissprot:RSGA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RSGA_ECOLI pepdigest swissprot:RSGA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RSGA_ECOLI pepinfo swissprot:RSGA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RSGA_ECOLI pepnet swissprot:RSGA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RSGA_ECOLI pepstats swissprot:RSGA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RSGA_ECOLI pepwheel swissprot:RSGA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RSGA_ECOLI pepwindow swissprot:RSGA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RSGA_ECOLI sigcleave swissprot:RSGA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RSGA_ECOLI ## Database ID URL or Descriptions # AltName NUSA_ECOLI N utilization substance protein A # AltName NUSA_ECOLI Transcription termination/antitermination L factor # BioGrid 4261878 15 # DISRUPTION PHENOTYPE Mutants are sensitive to DNA-damaging agents. {ECO:0000269|PubMed 20696893}. # DOMAIN NUSA_ECOLI The N-terminal region interacts with RNA polymerase. The central region is composed of 3 RNA binding domains, S1, KH 1 and KH 2. The C-terminal region contains 2 acidic repeats, AR1 and AR2, which bind to protein N from phage lambda during antitermination. {ECO 0000269|PubMed 15365170, ECO 0000269|PubMed 15987884, ECO 0000269|PubMed 21922055}. # EcoGene EG10665 nusA # FUNCTION NUSA_ECOLI Participates in both transcription termination and antitermination. Involved in a variety of cellular and viral termination and antitermination processes, such as Rho-dependent transcriptional termination, intrinsic termination, and phage lambda N-mediated transcriptional antitermination. Also important for coordinating the cellular responses to DNA damage by coupling the processes of nucleotide excision repair and translesion synthesis to transcription. {ECO 0000255|HAMAP-Rule MF_00945, ECO 0000269|PubMed 11719185, ECO 0000269|PubMed 20696893, ECO 0000269|PubMed 21922055, ECO 0000269|PubMed 2821282, ECO 0000269|PubMed 6199039, ECO 0000269|PubMed 6263495, ECO 0000269|PubMed 6265785, ECO 0000269|PubMed 7536848, ECO 0000269|PubMed 9139668}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000166 nucleotide binding; IEA:InterPro. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_function GO:0003723 RNA binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006353 DNA-templated transcription, termination; IEA:UniProtKB-HAMAP. # GO_process GO:0031564 transcription antitermination; IMP:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003723 RNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.30.1480.10 -; 1. # Gene3D 3.30.300.20 -; 2. # HAMAP MF_00945_B NusA_B # INDUCTION NUSA_ECOLI In response to low temperature. Negatively autoregulated. {ECO 0000269|PubMed 1847365, ECO 0000269|PubMed 2987884}. # INTERACTION NUSA_ECOLI Q47155 dinB; NbExp=3; IntAct=EBI-551571, EBI-1037359; # IntAct P0AFF6 42 # InterPro IPR003029 S1_domain # InterPro IPR004088 KH_dom_type_1 # InterPro IPR009019 KH_prok-type # InterPro IPR010213 Tscrpt_termination_fac_NusA # InterPro IPR010214 Tscrpt_termin_fac_NusA_C_rpt # InterPro IPR010995 DNA_repair_Rad51/TF_NusA_a-hlx # InterPro IPR012340 NA-bd_OB-fold # InterPro IPR013735 TF_NusA_N # InterPro IPR015946 KH_dom-like_a/b # InterPro IPR022967 S1_dom # InterPro IPR025249 KH_dom_NusA-like # InterPro IPR030842 NusA_bac # KEGG_Brite ko03009 Ribosome biogenesis # KEGG_Brite ko03021 Transcription machinery # Organism NUSA_ECOLI Escherichia coli (strain K12) # PATRIC 32121756 VBIEscCol129921_3264 # PDB 1U9L X-ray; 1.90 A; A/B=352-421 # PDB 1WCL NMR; -; A=351-426 # PDB 1WCN NMR; -; A=426-495 # PDB 2JZB NMR; -; B=424-495 # PDB 2KWP NMR; -; A=1-125 # PIR E65107 FJEC # PROSITE PS50084 KH_TYPE_1 # PROSITE PS50126 S1 # Pfam PF00575 S1 # Pfam PF08529 NusA_N # Pfam PF13184 KH_5 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Transcription termination/antitermination protein NusA {ECO:0000255|HAMAP-Rule MF_00945} # RefSeq NP_417638 NC_000913.3 # RefSeq WP_001031057 NZ_LN832404.1 # SIMILARITY Belongs to the NusA family. {ECO:0000255|HAMAP- Rule MF_00945}. # SIMILARITY Contains 1 S1 motif domain. {ECO:0000255|HAMAP- Rule MF_00945}. # SIMILARITY Contains 2 KH domains. {ECO:0000255|HAMAP- Rule MF_00945}. # SMART SM00316 S1 # SUBCELLULAR LOCATION NUSA_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00945, ECO 0000269|PubMed 17272300}. Note=Colocalizes with nucleoids. # SUBUNIT NUSA_ECOLI Monomer. Binds directly to the core enzyme of the DNA- dependent RNA polymerase and to nascent RNA. Also interacts with the termination Rho factor and the phage lambda N protein. {ECO 0000255|HAMAP-Rule MF_00945, ECO 0000269|PubMed 1856861, ECO 0000269|PubMed 6096352, ECO 0000269|PubMed 6154941, ECO 0000269|PubMed 6263495, ECO 0000269|PubMed 7536848}. # SUPFAM SSF47794 SSF47794; 2 # SUPFAM SSF50249 SSF50249 # SUPFAM SSF54814 SSF54814; 2 # SUPFAM SSF69705 SSF69705 # TIGRFAMs TIGR01953 NusA # TIGRFAMs TIGR01954 nusA_Cterm_rpt; 2 # eggNOG COG0195 LUCA # eggNOG ENOG4105CHV Bacteria BLAST swissprot:NUSA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NUSA_ECOLI BioCyc ECOL316407:JW3138-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3138-MONOMER BioCyc EcoCyc:EG10665-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10665-MONOMER COG COG0195 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0195 DIP DIP-47857N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47857N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1007/BF00430455 http://dx.doi.org/10.1007/BF00430455 DOI 10.1016/0022-2836(87)90486-4 http://dx.doi.org/10.1016/0022-2836(87)90486-4 DOI 10.1016/0022-2836(91)90015-X http://dx.doi.org/10.1016/0022-2836(91)90015-X DOI 10.1016/0092-8674(81)90332-9 http://dx.doi.org/10.1016/0092-8674(81)90332-9 DOI 10.1016/S0022-2836(05)80136-6 http://dx.doi.org/10.1016/S0022-2836(05)80136-6 DOI 10.1016/S0092-8674(01)00582-7 http://dx.doi.org/10.1016/S0092-8674(01)00582-7 DOI 10.1021/bi00297a004 http://dx.doi.org/10.1021/bi00297a004 DOI 10.1038/292215a0 http://dx.doi.org/10.1038/292215a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0405883101 http://dx.doi.org/10.1073/pnas.0405883101 DOI 10.1073/pnas.1005203107 http://dx.doi.org/10.1073/pnas.1005203107 DOI 10.1073/pnas.77.4.1991 http://dx.doi.org/10.1073/pnas.77.4.1991 DOI 10.1074/jbc.272.19.12265 http://dx.doi.org/10.1074/jbc.272.19.12265 DOI 10.1093/nar/12.7.3333 http://dx.doi.org/10.1093/nar/12.7.3333 DOI 10.1093/nar/13.9.3371 http://dx.doi.org/10.1093/nar/13.9.3371 DOI 10.1093/nar/gkl1158 http://dx.doi.org/10.1093/nar/gkl1158 DOI 10.1110/ps.051372205 http://dx.doi.org/10.1110/ps.051372205 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.4161/trns.2.3.15671 http://dx.doi.org/10.4161/trns.2.3.15671 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X00513 http://www.ebi.ac.uk/ena/data/view/X00513 EchoBASE EB0659 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0659 EcoGene EG10665 http://www.ecogene.org/geneInfo.php?eg_id=EG10665 EnsemblBacteria AAC76203 http://www.ensemblgenomes.org/id/AAC76203 EnsemblBacteria AAC76203 http://www.ensemblgenomes.org/id/AAC76203 EnsemblBacteria BAE77215 http://www.ensemblgenomes.org/id/BAE77215 EnsemblBacteria BAE77215 http://www.ensemblgenomes.org/id/BAE77215 EnsemblBacteria BAE77215 http://www.ensemblgenomes.org/id/BAE77215 EnsemblBacteria b3169 http://www.ensemblgenomes.org/id/b3169 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000166 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000166 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_process GO:0006353 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006353 GO_process GO:0031564 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031564 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.30.1480.10 http://www.cathdb.info/version/latest/superfamily/3.30.1480.10 Gene3D 3.30.300.20 http://www.cathdb.info/version/latest/superfamily/3.30.300.20 GeneID 947682 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947682 HAMAP MF_00945_B http://hamap.expasy.org/unirule/MF_00945_B HOGENOM HOG000006394 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006394&db=HOGENOM6 InParanoid P0AFF6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFF6 IntAct P0AFF6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFF6* InterPro IPR003029 http://www.ebi.ac.uk/interpro/entry/IPR003029 InterPro IPR004088 http://www.ebi.ac.uk/interpro/entry/IPR004088 InterPro IPR009019 http://www.ebi.ac.uk/interpro/entry/IPR009019 InterPro IPR010213 http://www.ebi.ac.uk/interpro/entry/IPR010213 InterPro IPR010214 http://www.ebi.ac.uk/interpro/entry/IPR010214 InterPro IPR010995 http://www.ebi.ac.uk/interpro/entry/IPR010995 InterPro IPR012340 http://www.ebi.ac.uk/interpro/entry/IPR012340 InterPro IPR013735 http://www.ebi.ac.uk/interpro/entry/IPR013735 InterPro IPR015946 http://www.ebi.ac.uk/interpro/entry/IPR015946 InterPro IPR022967 http://www.ebi.ac.uk/interpro/entry/IPR022967 InterPro IPR025249 http://www.ebi.ac.uk/interpro/entry/IPR025249 InterPro IPR030842 http://www.ebi.ac.uk/interpro/entry/IPR030842 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Brite ko03021 http://www.genome.jp/dbget-bin/www_bget?ko03021 KEGG_Gene ecj:JW3138 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3138 KEGG_Gene eco:b3169 http://www.genome.jp/dbget-bin/www_bget?eco:b3169 KEGG_Orthology KO:K02600 http://www.genome.jp/dbget-bin/www_bget?KO:K02600 MINT MINT-1220515 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1220515 OMA RAMIVEQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RAMIVEQ PDB 1U9L http://www.ebi.ac.uk/pdbe-srv/view/entry/1U9L PDB 1WCL http://www.ebi.ac.uk/pdbe-srv/view/entry/1WCL PDB 1WCN http://www.ebi.ac.uk/pdbe-srv/view/entry/1WCN PDB 2JZB http://www.ebi.ac.uk/pdbe-srv/view/entry/2JZB PDB 2KWP http://www.ebi.ac.uk/pdbe-srv/view/entry/2KWP PDBsum 1U9L http://www.ebi.ac.uk/pdbsum/1U9L PDBsum 1WCL http://www.ebi.ac.uk/pdbsum/1WCL PDBsum 1WCN http://www.ebi.ac.uk/pdbsum/1WCN PDBsum 2JZB http://www.ebi.ac.uk/pdbsum/2JZB PDBsum 2KWP http://www.ebi.ac.uk/pdbsum/2KWP PROSITE PS50084 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50084 PROSITE PS50126 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50126 PSORT swissprot:NUSA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NUSA_ECOLI PSORT-B swissprot:NUSA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NUSA_ECOLI PSORT2 swissprot:NUSA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NUSA_ECOLI Pfam PF00575 http://pfam.xfam.org/family/PF00575 Pfam PF08529 http://pfam.xfam.org/family/PF08529 Pfam PF13184 http://pfam.xfam.org/family/PF13184 Phobius swissprot:NUSA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NUSA_ECOLI PhylomeDB P0AFF6 http://phylomedb.org/?seqid=P0AFF6 ProteinModelPortal P0AFF6 http://www.proteinmodelportal.org/query/uniprot/P0AFF6 PubMed 11719185 http://www.ncbi.nlm.nih.gov/pubmed/11719185 PubMed 15365170 http://www.ncbi.nlm.nih.gov/pubmed/15365170 PubMed 15987884 http://www.ncbi.nlm.nih.gov/pubmed/15987884 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17272300 http://www.ncbi.nlm.nih.gov/pubmed/17272300 PubMed 1847365 http://www.ncbi.nlm.nih.gov/pubmed/1847365 PubMed 1856861 http://www.ncbi.nlm.nih.gov/pubmed/1856861 PubMed 20696893 http://www.ncbi.nlm.nih.gov/pubmed/20696893 PubMed 21922055 http://www.ncbi.nlm.nih.gov/pubmed/21922055 PubMed 2821282 http://www.ncbi.nlm.nih.gov/pubmed/2821282 PubMed 2987884 http://www.ncbi.nlm.nih.gov/pubmed/2987884 PubMed 3027511 http://www.ncbi.nlm.nih.gov/pubmed/3027511 PubMed 6096352 http://www.ncbi.nlm.nih.gov/pubmed/6096352 PubMed 6154941 http://www.ncbi.nlm.nih.gov/pubmed/6154941 PubMed 6199039 http://www.ncbi.nlm.nih.gov/pubmed/6199039 PubMed 6263495 http://www.ncbi.nlm.nih.gov/pubmed/6263495 PubMed 6265785 http://www.ncbi.nlm.nih.gov/pubmed/6265785 PubMed 6326058 http://www.ncbi.nlm.nih.gov/pubmed/6326058 PubMed 7536848 http://www.ncbi.nlm.nih.gov/pubmed/7536848 PubMed 9139668 http://www.ncbi.nlm.nih.gov/pubmed/9139668 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_417638 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417638 RefSeq WP_001031057 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001031057 SMART SM00316 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00316 SMR P0AFF6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFF6 STRING 511145.b3169 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3169&targetmode=cogs STRING COG0195 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0195&targetmode=cogs SUPFAM SSF47794 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47794 SUPFAM SSF50249 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50249 SUPFAM SSF54814 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54814 SUPFAM SSF69705 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF69705 SWISS-2DPAGE P0AFF6 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AFF6 TIGRFAMs TIGR01953 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01953 TIGRFAMs TIGR01954 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01954 UniProtKB NUSA_ECOLI http://www.uniprot.org/uniprot/NUSA_ECOLI UniProtKB-AC P0AFF6 http://www.uniprot.org/uniprot/P0AFF6 charge swissprot:NUSA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NUSA_ECOLI eggNOG COG0195 http://eggnogapi.embl.de/nog_data/html/tree/COG0195 eggNOG ENOG4105CHV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CHV epestfind swissprot:NUSA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NUSA_ECOLI garnier swissprot:NUSA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NUSA_ECOLI helixturnhelix swissprot:NUSA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NUSA_ECOLI hmoment swissprot:NUSA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NUSA_ECOLI iep swissprot:NUSA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NUSA_ECOLI inforesidue swissprot:NUSA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NUSA_ECOLI octanol swissprot:NUSA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NUSA_ECOLI pepcoil swissprot:NUSA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NUSA_ECOLI pepdigest swissprot:NUSA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NUSA_ECOLI pepinfo swissprot:NUSA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NUSA_ECOLI pepnet swissprot:NUSA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NUSA_ECOLI pepstats swissprot:NUSA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NUSA_ECOLI pepwheel swissprot:NUSA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NUSA_ECOLI pepwindow swissprot:NUSA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NUSA_ECOLI sigcleave swissprot:NUSA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NUSA_ECOLI ## Database ID URL or Descriptions # AltName EIICBA-Nag {ECO:0000303|PubMed 3056518} # AltName PTS system N-acetylglucosamine-specific EIIA component {ECO:0000303|PubMed 3056518} # AltName PTS system N-acetylglucosamine-specific EIIB component {ECO:0000303|PubMed 3056518} # AltName PTS system N-acetylglucosamine-specific EIIB component {ECO:0000303|PubMed 3056518} # AltName PTS system N-acetylglucosamine-specific EIIC component {ECO:0000303|PubMed 3056518} # AltName PTS system N-acetylglucosamine-specific EIIC component {ECO:0000303|PubMed 3056518} # BioGrid 4261209 4 # CATALYTIC ACTIVITY [Protein]-N(pi)-phospho-L-histidine + N- acetyl-D-glucosamine(Side 1) = [protein]-L-histidine + N-acetyl-D- glucosamine 6-phosphate(Side 2). {ECO:0000269|PubMed 4919472}. # CDD cd00212 PTS_IIB_glc # COFACTOR PTW3C_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000250|UniProtKB P69783}; # DISRUPTION PHENOTYPE Cells lacking nagE and nagA reduce by 50% the amount of GlcNAc6P. Together with the mutations of the genes of the peptidoglycan recycling pathway (ampG, anmK, murQ, nagK and nagZ), the accumulation of GlcNAc6P is eliminated. {ECO:0000269|PubMed 19617367}. # DOMAIN PTW3C_ECOLI The PTS EIIA type-1 domain is phosphorylated by phospho- HPr on a histidyl residue. Then, it transfers the phosphoryl group to the PTS EIIB type-1 domain. {ECO 0000255|PROSITE- ProRule PRU00416}. # DOMAIN PTW3C_ECOLI The PTS EIIB type-1 domain is phosphorylated by phospho- EIIA on a cysteinyl residue. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the PTS EIIC type-1 domain. {ECO 0000255|PROSITE- ProRule PRU00421}. # DOMAIN PTW3C_ECOLI The PTS EIIC type-1 domain forms the PTS system translocation channel and contains the specific substrate-binding site. {ECO 0000255|PROSITE-ProRule PRU00426}. # ENZYME REGULATION P-chloromercuribenzoate inhibits the accumulation of both N-acetyl-D-glucosamine and antibiotic streptozotocin (2-deoxy-2-(3-methyl-3-nitrosoureido)-D- glucopyranose). N-acetyl-D-glucosamine is a competitive inhibitor for the uptake of streptozotocin. {ECO:0000269|PubMed 161156}. # EcoGene EG10635 nagE # FUNCTION PTW3C_ECOLI The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (PubMed 4919472). This system is involved in N- acetylglucosamine transport (PubMed 4919472). It can also transport and phosphorylate the antibiotic streptozotocin (PubMed 161156). Could play a significant role in the recycling of peptidoglycan (PubMed 19617367). {ECO 0000269|PubMed 161156, ECO 0000269|PubMed 19617367, ECO 0000269|PubMed 4919472, ECO 0000305|PubMed 3056518}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_component GO:0019866 organelle inner membrane; IEA:InterPro. # GO_function GO:0008982 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:InterPro. # GO_function GO:0015572 N-acetylglucosamine transmembrane transporter activity; IEA:InterPro. # GO_function GO:0016301 kinase activity; IEA:UniProtKB-KW. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0090586 protein-phosphocysteine-N-acetylglucosamine phosphotransferase system transporter activity; IDA:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IDA:EcoCyc. # GO_process GO:0015764 N-acetylglucosamine transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # GOslim_process GO:0006950 response to stress # Gene3D 3.30.1360.60 -; 1. # INDUCTION PTW3C_ECOLI Induced by N-acetylglucosamine-6-phosphate and repressed by NagC. {ECO 0000269|PubMed 1766379, ECO 0000269|PubMed 7791215}. # InterPro IPR001127 PTS_EIIA_1_perm # InterPro IPR001996 PTS_IIB_1 # InterPro IPR003352 PTS_EIIC # InterPro IPR010974 PTS_IIBC_nag # InterPro IPR011055 Dup_hybrid_motif # InterPro IPR013013 PTS_EIIC_1 # InterPro IPR018113 PTrfase_EIIB_Cys # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00267 PTS system, N-acetylglucosamine-specific II component # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko00520 Amino sugar and nucleotide sugar metabolism # KEGG_Pathway ko02060 Phosphotransferase system (PTS) # Organism PTW3C_ECOLI Escherichia coli (strain K12) # PATRIC 32116545 VBIEscCol129921_0705 # PIR B29895 WQEC2N # PROSITE PS00371 PTS_EIIA_TYPE_1_HIS # PROSITE PS01035 PTS_EIIB_TYPE_1_CYS # PROSITE PS51093 PTS_EIIA_TYPE_1 # PROSITE PS51098 PTS_EIIB_TYPE_1 # PROSITE PS51103 PTS_EIIC_TYPE_1 # Pfam PF00358 PTS_EIIA_1 # Pfam PF00367 PTS_EIIB # Pfam PF02378 PTS_EIIC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName N-acetylglucosamine permease IIC component {ECO:0000303|PubMed 3056518} # RecName N-acetylglucosamine-specific phosphotransferase enzyme IIA component {ECO:0000303|PubMed 3056518} # RecName N-acetylglucosamine-specific phosphotransferase enzyme IIB component {ECO:0000303|PubMed 3056518} # RecName PTS system N-acetylglucosamine-specific EIICBA component {ECO:0000303|PubMed 3056518} # RefSeq NP_415205 NC_000913.3 # RefSeq WP_001023093 NZ_LN832404.1 # SIMILARITY Contains 1 PTS EIIA type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00416}. # SIMILARITY Contains 1 PTS EIIB type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00421}. # SIMILARITY Contains 1 PTS EIIC type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00426}. # SUBCELLULAR LOCATION PTW3C_ECOLI Cell inner membrane {ECO 0000255|PROSITE- ProRule PRU00426, ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00426, ECO 0000269|PubMed 15919996}. # SUPFAM SSF51261 SSF51261 # SUPFAM SSF55604 SSF55604 # TCDB 4.A.1.1 the pts glucose-glucoside (glc) family # TIGRFAMs TIGR00826 EIIB_glc # TIGRFAMs TIGR00830 PTBA # TIGRFAMs TIGR01998 PTS-II-BC-nag # eggNOG COG1263 LUCA # eggNOG COG1264 LUCA # eggNOG COG2190 LUCA # eggNOG ENOG4105CI1 Bacteria BLAST swissprot:PTW3C_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTW3C_ECOLI BioCyc ECOL316407:JW0665-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0665-MONOMER BioCyc EcoCyc:NAGE-MONOMER http://biocyc.org/getid?id=EcoCyc:NAGE-MONOMER BioCyc MetaCyc:NAGE-MONOMER http://biocyc.org/getid?id=MetaCyc:NAGE-MONOMER COG COG1263 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1263 DOI 10.1006/jmbi.1995.0346 http://dx.doi.org/10.1006/jmbi.1995.0346 DOI 10.1016/0378-1119(88)90558-6 http://dx.doi.org/10.1016/0378-1119(88)90558-6 DOI 10.1021/bi00416a034 http://dx.doi.org/10.1021/bi00416a034 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj1180089 http://dx.doi.org/10.1042/bj1180089 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1991.tb00828.x http://dx.doi.org/10.1111/j.1365-2958.1991.tb00828.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AAC.16.6.801 http://dx.doi.org/10.1128/AAC.16.6.801 DOI 10.1128/JB.00448-09 http://dx.doi.org/10.1128/JB.00448-09 EC_number EC:2.7.1.193 {ECO:0000269|PubMed:4919472} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.193 {ECO:0000269|PubMed:4919472} EC_number EC:2.7.1.193 {ECO:0000269|PubMed:4919472} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.193 {ECO:0000269|PubMed:4919472} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M19284 http://www.ebi.ac.uk/ena/data/view/M19284 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.193 {ECO:0000269|PubMed:4919472} http://enzyme.expasy.org/EC/2.7.1.193 {ECO:0000269|PubMed:4919472} ENZYME 2.7.1.193 {ECO:0000269|PubMed:4919472} http://enzyme.expasy.org/EC/2.7.1.193 {ECO:0000269|PubMed:4919472} EchoBASE EB0629 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0629 EcoGene EG10635 http://www.ecogene.org/geneInfo.php?eg_id=EG10635 EnsemblBacteria AAC73773 http://www.ensemblgenomes.org/id/AAC73773 EnsemblBacteria AAC73773 http://www.ensemblgenomes.org/id/AAC73773 EnsemblBacteria BAA35327 http://www.ensemblgenomes.org/id/BAA35327 EnsemblBacteria BAA35327 http://www.ensemblgenomes.org/id/BAA35327 EnsemblBacteria BAA35327 http://www.ensemblgenomes.org/id/BAA35327 EnsemblBacteria b0679 http://www.ensemblgenomes.org/id/b0679 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0019866 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019866 GO_function GO:0008982 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008982 GO_function GO:0015572 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015572 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0090586 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090586 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GO_process GO:0015764 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015764 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.30.1360.60 http://www.cathdb.info/version/latest/superfamily/3.30.1360.60 GeneID 945292 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945292 HOGENOM HOG000250993 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000250993&db=HOGENOM6 InParanoid P09323 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P09323 IntEnz 2.7.1.193 {ECO:0000269|PubMed:4919472} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.193 {ECO:0000269|PubMed:4919472} IntEnz 2.7.1.193 {ECO:0000269|PubMed:4919472} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.193 {ECO:0000269|PubMed:4919472} InterPro IPR001127 http://www.ebi.ac.uk/interpro/entry/IPR001127 InterPro IPR001996 http://www.ebi.ac.uk/interpro/entry/IPR001996 InterPro IPR003352 http://www.ebi.ac.uk/interpro/entry/IPR003352 InterPro IPR010974 http://www.ebi.ac.uk/interpro/entry/IPR010974 InterPro IPR011055 http://www.ebi.ac.uk/interpro/entry/IPR011055 InterPro IPR013013 http://www.ebi.ac.uk/interpro/entry/IPR013013 InterPro IPR018113 http://www.ebi.ac.uk/interpro/entry/IPR018113 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0665 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0665 KEGG_Gene eco:b0679 http://www.genome.jp/dbget-bin/www_bget?eco:b0679 KEGG_Orthology KO:K02804 http://www.genome.jp/dbget-bin/www_bget?KO:K02804 KEGG_Pathway ko00520 http://www.genome.jp/kegg-bin/show_pathway?ko00520 KEGG_Pathway ko02060 http://www.genome.jp/kegg-bin/show_pathway?ko02060 KEGG_Reaction rn:R05199 http://www.genome.jp/dbget-bin/www_bget?rn:R05199 OMA ACLAMYR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ACLAMYR PROSITE PS00371 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00371 PROSITE PS01035 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01035 PROSITE PS51093 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51093 PROSITE PS51098 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51098 PROSITE PS51103 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51103 PSORT swissprot:PTW3C_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTW3C_ECOLI PSORT-B swissprot:PTW3C_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTW3C_ECOLI PSORT2 swissprot:PTW3C_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTW3C_ECOLI Pfam PF00358 http://pfam.xfam.org/family/PF00358 Pfam PF00367 http://pfam.xfam.org/family/PF00367 Pfam PF02378 http://pfam.xfam.org/family/PF02378 Phobius swissprot:PTW3C_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTW3C_ECOLI PhylomeDB P09323 http://phylomedb.org/?seqid=P09323 ProteinModelPortal P09323 http://www.proteinmodelportal.org/query/uniprot/P09323 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 161156 http://www.ncbi.nlm.nih.gov/pubmed/161156 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1766379 http://www.ncbi.nlm.nih.gov/pubmed/1766379 PubMed 19617367 http://www.ncbi.nlm.nih.gov/pubmed/19617367 PubMed 3056518 http://www.ncbi.nlm.nih.gov/pubmed/3056518 PubMed 3284790 http://www.ncbi.nlm.nih.gov/pubmed/3284790 PubMed 4919472 http://www.ncbi.nlm.nih.gov/pubmed/4919472 PubMed 7791215 http://www.ncbi.nlm.nih.gov/pubmed/7791215 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415205 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415205 RefSeq WP_001023093 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001023093 SMR P09323 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P09323 STRING 511145.b0679 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0679&targetmode=cogs STRING COG1263 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1263&targetmode=cogs SUPFAM SSF51261 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51261 SUPFAM SSF55604 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55604 TCDB 4.A.1.1 http://www.tcdb.org/search/result.php?tc=4.A.1.1 TIGRFAMs TIGR00826 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00826 TIGRFAMs TIGR00830 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00830 TIGRFAMs TIGR01998 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01998 UniProtKB PTW3C_ECOLI http://www.uniprot.org/uniprot/PTW3C_ECOLI UniProtKB-AC P09323 http://www.uniprot.org/uniprot/P09323 charge swissprot:PTW3C_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTW3C_ECOLI eggNOG COG1263 http://eggnogapi.embl.de/nog_data/html/tree/COG1263 eggNOG COG1264 http://eggnogapi.embl.de/nog_data/html/tree/COG1264 eggNOG COG2190 http://eggnogapi.embl.de/nog_data/html/tree/COG2190 eggNOG ENOG4105CI1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CI1 epestfind swissprot:PTW3C_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTW3C_ECOLI garnier swissprot:PTW3C_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTW3C_ECOLI helixturnhelix swissprot:PTW3C_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTW3C_ECOLI hmoment swissprot:PTW3C_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTW3C_ECOLI iep swissprot:PTW3C_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTW3C_ECOLI inforesidue swissprot:PTW3C_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTW3C_ECOLI octanol swissprot:PTW3C_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTW3C_ECOLI pepcoil swissprot:PTW3C_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTW3C_ECOLI pepdigest swissprot:PTW3C_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTW3C_ECOLI pepinfo swissprot:PTW3C_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTW3C_ECOLI pepnet swissprot:PTW3C_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTW3C_ECOLI pepstats swissprot:PTW3C_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTW3C_ECOLI pepwheel swissprot:PTW3C_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTW3C_ECOLI pepwindow swissprot:PTW3C_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTW3C_ECOLI sigcleave swissprot:PTW3C_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTW3C_ECOLI ## Database ID URL or Descriptions # BioGrid 4262659 2 # EcoGene EG11926 yjbH # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_process GO:0045226 extracellular polysaccharide biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # IntAct P32689 3 # InterPro IPR010344 YbjH # Organism YJBH_ECOLI Escherichia coli (strain K12) # PATRIC 32123587 VBIEscCol129921_4142 # PIR D65210 D65210 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF06082 YjbH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJBH_ECOLI Uncharacterized lipoprotein YjbH # RefSeq NP_418453 NC_000913.3 # RefSeq WP_000745776 NZ_LN832404.1 # SIMILARITY To E.coli YmcA. {ECO 0000305}. # SUBCELLULAR LOCATION YJBH_ECOLI Cell membrane {ECO 0000305}; Lipid-anchor {ECO 0000305}. # eggNOG ENOG4105E3R Bacteria # eggNOG ENOG410XQV2 LUCA BLAST swissprot:YJBH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJBH_ECOLI BioCyc ECOL316407:JW3989-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3989-MONOMER BioCyc EcoCyc:EG11926-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11926-MONOMER DIP DIP-12537N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12537N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1870 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1870 EcoGene EG11926 http://www.ecogene.org/geneInfo.php?eg_id=EG11926 EnsemblBacteria AAC76999 http://www.ensemblgenomes.org/id/AAC76999 EnsemblBacteria AAC76999 http://www.ensemblgenomes.org/id/AAC76999 EnsemblBacteria BAE78031 http://www.ensemblgenomes.org/id/BAE78031 EnsemblBacteria BAE78031 http://www.ensemblgenomes.org/id/BAE78031 EnsemblBacteria BAE78031 http://www.ensemblgenomes.org/id/BAE78031 EnsemblBacteria b4029 http://www.ensemblgenomes.org/id/b4029 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_process GO:0045226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045226 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 948527 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948527 HOGENOM HOG000280356 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000280356&db=HOGENOM6 IntAct P32689 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32689* InterPro IPR010344 http://www.ebi.ac.uk/interpro/entry/IPR010344 KEGG_Gene ecj:JW3989 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3989 KEGG_Gene eco:b4029 http://www.genome.jp/dbget-bin/www_bget?eco:b4029 MINT MINT-1267602 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1267602 OMA QTPWEPL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QTPWEPL PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YJBH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJBH_ECOLI PSORT-B swissprot:YJBH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJBH_ECOLI PSORT2 swissprot:YJBH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJBH_ECOLI Pfam PF06082 http://pfam.xfam.org/family/PF06082 Phobius swissprot:YJBH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJBH_ECOLI ProteinModelPortal P32689 http://www.proteinmodelportal.org/query/uniprot/P32689 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418453 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418453 RefSeq WP_000745776 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000745776 STRING 511145.b4029 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4029&targetmode=cogs UniProtKB YJBH_ECOLI http://www.uniprot.org/uniprot/YJBH_ECOLI UniProtKB-AC P32689 http://www.uniprot.org/uniprot/P32689 charge swissprot:YJBH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJBH_ECOLI eggNOG ENOG4105E3R http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E3R eggNOG ENOG410XQV2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQV2 epestfind swissprot:YJBH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJBH_ECOLI garnier swissprot:YJBH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJBH_ECOLI helixturnhelix swissprot:YJBH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJBH_ECOLI hmoment swissprot:YJBH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJBH_ECOLI iep swissprot:YJBH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJBH_ECOLI inforesidue swissprot:YJBH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJBH_ECOLI octanol swissprot:YJBH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJBH_ECOLI pepcoil swissprot:YJBH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJBH_ECOLI pepdigest swissprot:YJBH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJBH_ECOLI pepinfo swissprot:YJBH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJBH_ECOLI pepnet swissprot:YJBH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJBH_ECOLI pepstats swissprot:YJBH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJBH_ECOLI pepwheel swissprot:YJBH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJBH_ECOLI pepwindow swissprot:YJBH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJBH_ECOLI sigcleave swissprot:YJBH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJBH_ECOLI ## Database ID URL or Descriptions # AltName OSME_ECOLI Activator of ntr-like gene protein # BioGrid 4260317 4 # EcoGene EG10044 osmE # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0019867 outer membrane; IEA:InterPro. # GO_process GO:0006970 response to osmotic stress; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006950 response to stress # INDUCTION OSME_ECOLI By elevated osmotic pressure in the growth medium. # IntAct P0ADB1 2 # InterPro IPR007450 Lipoprotein_SmpA/OmlA # Organism OSME_ECOLI Escherichia coli (strain K12) # PATRIC 32118787 VBIEscCol129921_1811 # PIR I57918 I57918 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF04355 SmpA_OmlA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName OSME_ECOLI Osmotically-inducible lipoprotein E # RefSeq NP_416253 NC_000913.3 # RefSeq WP_001039044 NZ_LN832404.1 # SUBCELLULAR LOCATION OSME_ECOLI Cell membrane {ECO 0000305}; Lipid-anchor {ECO 0000305}. # eggNOG ENOG4105KKI Bacteria # eggNOG ENOG4111JD7 LUCA BLAST swissprot:OSME_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:OSME_ECOLI BioCyc ECOL316407:JW1728-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1728-MONOMER BioCyc EcoCyc:EG10044-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10044-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1111/j.1365-2958.1995.tb02418.x http://dx.doi.org/10.1111/j.1365-2958.1995.tb02418.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X60186 http://www.ebi.ac.uk/ena/data/view/X60186 EMBL X75957 http://www.ebi.ac.uk/ena/data/view/X75957 EchoBASE EB0042 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0042 EcoGene EG10044 http://www.ecogene.org/geneInfo.php?eg_id=EG10044 EnsemblBacteria AAC74809 http://www.ensemblgenomes.org/id/AAC74809 EnsemblBacteria AAC74809 http://www.ensemblgenomes.org/id/AAC74809 EnsemblBacteria BAA15528 http://www.ensemblgenomes.org/id/BAA15528 EnsemblBacteria BAA15528 http://www.ensemblgenomes.org/id/BAA15528 EnsemblBacteria BAA15528 http://www.ensemblgenomes.org/id/BAA15528 EnsemblBacteria b1739 http://www.ensemblgenomes.org/id/b1739 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0019867 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019867 GO_process GO:0006970 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006970 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 945305 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945305 HOGENOM HOG000121065 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000121065&db=HOGENOM6 InParanoid P0ADB1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADB1 IntAct P0ADB1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADB1* InterPro IPR007450 http://www.ebi.ac.uk/interpro/entry/IPR007450 KEGG_Gene ecj:JW1728 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1728 KEGG_Gene eco:b1739 http://www.genome.jp/dbget-bin/www_bget?eco:b1739 KEGG_Orthology KO:K04064 http://www.genome.jp/dbget-bin/www_bget?KO:K04064 OMA VTMIHAR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VTMIHAR PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:OSME_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:OSME_ECOLI PSORT-B swissprot:OSME_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:OSME_ECOLI PSORT2 swissprot:OSME_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:OSME_ECOLI Pfam PF04355 http://pfam.xfam.org/family/PF04355 Phobius swissprot:OSME_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:OSME_ECOLI ProteinModelPortal P0ADB1 http://www.proteinmodelportal.org/query/uniprot/P0ADB1 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7565114 http://www.ncbi.nlm.nih.gov/pubmed/7565114 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416253 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416253 RefSeq WP_001039044 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001039044 SMR P0ADB1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADB1 STRING 511145.b1739 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1739&targetmode=cogs UniProtKB OSME_ECOLI http://www.uniprot.org/uniprot/OSME_ECOLI UniProtKB-AC P0ADB1 http://www.uniprot.org/uniprot/P0ADB1 charge swissprot:OSME_ECOLI http://rest.g-language.org/emboss/charge/swissprot:OSME_ECOLI eggNOG ENOG4105KKI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KKI eggNOG ENOG4111JD7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111JD7 epestfind swissprot:OSME_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:OSME_ECOLI garnier swissprot:OSME_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:OSME_ECOLI helixturnhelix swissprot:OSME_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:OSME_ECOLI hmoment swissprot:OSME_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:OSME_ECOLI iep swissprot:OSME_ECOLI http://rest.g-language.org/emboss/iep/swissprot:OSME_ECOLI inforesidue swissprot:OSME_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:OSME_ECOLI octanol swissprot:OSME_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:OSME_ECOLI pepcoil swissprot:OSME_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:OSME_ECOLI pepdigest swissprot:OSME_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:OSME_ECOLI pepinfo swissprot:OSME_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:OSME_ECOLI pepnet swissprot:OSME_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:OSME_ECOLI pepstats swissprot:OSME_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:OSME_ECOLI pepwheel swissprot:OSME_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:OSME_ECOLI pepwindow swissprot:OSME_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:OSME_ECOLI sigcleave swissprot:OSME_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:OSME_ECOLI ## Database ID URL or Descriptions # AltName SYE_ECOLI Glutamyl-tRNA synthetase # BIOPHYSICOCHEMICAL PROPERTIES SYE_ECOLI Kinetic parameters KM=0.32 uM for tRNA(Glu) {ECO 0000269|PubMed 14764088}; KM=0.105 mM for Glu {ECO 0000269|PubMed 14764088}; # BRENDA 6.1.1.17 2026 # BioGrid 4259193 14 # CATALYTIC ACTIVITY ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu). {ECO:0000269|PubMed 8218204}. # CDD cd00808 GluRS_core # COFACTOR SYE_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 7797500, ECO 0000269|PubMed 8218204}; Note=Binds 1 zinc ion per subunit. {ECO 0000269|PubMed 7797500, ECO 0000269|PubMed 8218204}; # ENZYME REGULATION SYE_ECOLI Inhibited by 1,10-phenanthroline. Phosphorylation of Ser-239 by HipA inhibits aminoacylation of tRNA(Glu). {ECO 0000269|PubMed 24095282, ECO 0000269|PubMed 8218204}. # EcoGene EG10407 gltX # FUNCTION SYE_ECOLI Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). # FUNCTION SYE_ECOLI Phosphorylation of GltX by HipA prevents it from being charged, leading to an increase in uncharged tRNA(Glu). This induces amino acid starvation and the stringent response via RelA/SpoT and increased ppGpp levels, which inhibits replication, transcription, translation and cell wall synthesis, reducing growth and leading to multidrug resistance and persistence. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000049 tRNA binding; IEA:InterPro. # GO_function GO:0003723 RNA binding; IBA:GO_Central. # GO_function GO:0004818 glutamate-tRNA ligase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_process GO:0006424 glutamyl-tRNA aminoacylation; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0006520 cellular amino acid metabolic process # Gene3D 1.10.10.350 -; 1. # Gene3D 1.10.1160.10 -; 1. # Gene3D 3.40.50.620 -; 2. # HAMAP MF_00022_B Glu_tRNA_synth_B # IntAct P04805 16 # InterPro IPR000924 Glu/Gln-tRNA-synth # InterPro IPR001412 aa-tRNA-synth_I_CS # InterPro IPR004527 Glu-tRNA-ligase_bac/mito # InterPro IPR008925 aa-tRNA-synth_I_codon-bd # InterPro IPR014729 Rossmann-like_a/b/a_fold # InterPro IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom # InterPro IPR020061 Glu/Gln-tRNA-synth_Ib_a-bdl # InterPro IPR020751 aa-tRNA-synth_I_codon-bd_sub2 # InterPro IPR033910 GluRS_core # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01007 Amino acid related enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # KEGG_Pathway ko00860 Porphyrin and chlorophyll metabolism # KEGG_Pathway ko00970 Aminoacyl-tRNA biosynthesis # MASS SPECTROMETRY Mass=56224.09; Method=MALDI; Range=1-471; Evidence={ECO:0000269|PubMed 24095282}; # MASS SPECTROMETRY Mass=56304.11; Method=MALDI; Range=1-471; Note=Phosphorylated.; Evidence={ECO:0000269|PubMed 24095282}; # MISCELLANEOUS SYE_ECOLI This is the smallest aminoacyl-tRNA synthetase of E.coli; it does not bind glutamate in the absence of cognate tRNA, which is therefore required for activation of the amino acid substrate. # Organism SYE_ECOLI Escherichia coli (strain K12) # PATRIC 32120177 VBIEscCol129921_2495 # PIR A25956 SYECET # PRINTS PR00987 TRNASYNTHGLU # PROSITE PS00178 AA_TRNA_LIGASE_I # PTM SYE_ECOLI Phosphorylated by HipA on Ser-239 in the presence but not absence of tRNA(Glu). Phosphorylated protein cannot aminoacylate tRNA(Glu). {ECO 0000269|PubMed 24095282}. # Pfam PF00749 tRNA-synt_1c # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SYE_ECOLI Glutamate--tRNA ligase # RefSeq NP_416899 NC_000913.3 # RefSeq WP_000695655 NZ_LN832404.1 # SIMILARITY Belongs to the class-I aminoacyl-tRNA synthetase family. {ECO 0000305}. # SUBCELLULAR LOCATION SYE_ECOLI Cytoplasm. # SUBUNIT Monomer. {ECO:0000269|PubMed 3015933}. # SUPFAM SSF48163 SSF48163 # TIGRFAMs TIGR00464 gltX_bact # eggNOG COG0008 LUCA # eggNOG ENOG4105C20 Bacteria BLAST swissprot:SYE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SYE_ECOLI BioCyc ECOL316407:JW2395-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2395-MONOMER BioCyc EcoCyc:GLURS-MONOMER http://biocyc.org/getid?id=EcoCyc:GLURS-MONOMER BioCyc MetaCyc:GLURS-MONOMER http://biocyc.org/getid?id=MetaCyc:GLURS-MONOMER COG COG0008 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0008 DIP DIP-9810N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9810N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0022-2836(90)90340-R http://dx.doi.org/10.1016/0022-2836(90)90340-R DOI 10.1016/j.molcel.2013.08.045 http://dx.doi.org/10.1016/j.molcel.2013.08.045 DOI 10.1021/bi00093a016 http://dx.doi.org/10.1021/bi00093a016 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.270.25.15162 http://dx.doi.org/10.1074/jbc.270.25.15162 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1432-1033.2003.03976.x http://dx.doi.org/10.1111/j.1432-1033.2003.03976.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.1.1.17 http://www.genome.jp/dbget-bin/www_bget?EC:6.1.1.17 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M13687 http://www.ebi.ac.uk/ena/data/view/M13687 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X55737 http://www.ebi.ac.uk/ena/data/view/X55737 EMBL X63976 http://www.ebi.ac.uk/ena/data/view/X63976 ENZYME 6.1.1.17 http://enzyme.expasy.org/EC/6.1.1.17 EchoBASE EB0402 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0402 EcoGene EG10407 http://www.ecogene.org/geneInfo.php?eg_id=EG10407 EnsemblBacteria AAC75457 http://www.ensemblgenomes.org/id/AAC75457 EnsemblBacteria AAC75457 http://www.ensemblgenomes.org/id/AAC75457 EnsemblBacteria BAA16272 http://www.ensemblgenomes.org/id/BAA16272 EnsemblBacteria BAA16272 http://www.ensemblgenomes.org/id/BAA16272 EnsemblBacteria BAA16272 http://www.ensemblgenomes.org/id/BAA16272 EnsemblBacteria b2400 http://www.ensemblgenomes.org/id/b2400 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000049 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0004818 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004818 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_process GO:0006424 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006424 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 Gene3D 1.10.10.350 http://www.cathdb.info/version/latest/superfamily/1.10.10.350 Gene3D 1.10.1160.10 http://www.cathdb.info/version/latest/superfamily/1.10.1160.10 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 GeneID 946906 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946906 HAMAP MF_00022_B http://hamap.expasy.org/unirule/MF_00022_B HOGENOM HOG000252722 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000252722&db=HOGENOM6 InParanoid P04805 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P04805 IntAct P04805 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P04805* IntEnz 6.1.1.17 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.1.1.17 InterPro IPR000924 http://www.ebi.ac.uk/interpro/entry/IPR000924 InterPro IPR001412 http://www.ebi.ac.uk/interpro/entry/IPR001412 InterPro IPR004527 http://www.ebi.ac.uk/interpro/entry/IPR004527 InterPro IPR008925 http://www.ebi.ac.uk/interpro/entry/IPR008925 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 InterPro IPR020058 http://www.ebi.ac.uk/interpro/entry/IPR020058 InterPro IPR020061 http://www.ebi.ac.uk/interpro/entry/IPR020061 InterPro IPR020751 http://www.ebi.ac.uk/interpro/entry/IPR020751 InterPro IPR033910 http://www.ebi.ac.uk/interpro/entry/IPR033910 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW2395 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2395 KEGG_Gene eco:b2400 http://www.genome.jp/dbget-bin/www_bget?eco:b2400 KEGG_Orthology KO:K01885 http://www.genome.jp/dbget-bin/www_bget?KO:K01885 KEGG_Pathway ko00860 http://www.genome.jp/kegg-bin/show_pathway?ko00860 KEGG_Pathway ko00970 http://www.genome.jp/kegg-bin/show_pathway?ko00970 KEGG_Reaction rn:R05578 http://www.genome.jp/dbget-bin/www_bget?rn:R05578 MINT MINT-1296746 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1296746 OMA HGATNVM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HGATNVM PRINTS PR00987 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00987 PROSITE PS00178 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00178 PSORT swissprot:SYE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SYE_ECOLI PSORT-B swissprot:SYE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SYE_ECOLI PSORT2 swissprot:SYE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SYE_ECOLI Pfam PF00749 http://pfam.xfam.org/family/PF00749 Phobius swissprot:SYE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SYE_ECOLI PhylomeDB P04805 http://phylomedb.org/?seqid=P04805 ProteinModelPortal P04805 http://www.proteinmodelportal.org/query/uniprot/P04805 PubMed 14764088 http://www.ncbi.nlm.nih.gov/pubmed/14764088 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2201777 http://www.ncbi.nlm.nih.gov/pubmed/2201777 PubMed 24095282 http://www.ncbi.nlm.nih.gov/pubmed/24095282 PubMed 3015933 http://www.ncbi.nlm.nih.gov/pubmed/3015933 PubMed 6280993 http://www.ncbi.nlm.nih.gov/pubmed/6280993 PubMed 6986385 http://www.ncbi.nlm.nih.gov/pubmed/6986385 PubMed 7797500 http://www.ncbi.nlm.nih.gov/pubmed/7797500 PubMed 8218204 http://www.ncbi.nlm.nih.gov/pubmed/8218204 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_416899 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416899 RefSeq WP_000695655 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000695655 SMR P04805 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P04805 STRING 511145.b2400 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2400&targetmode=cogs STRING COG0008 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0008&targetmode=cogs SUPFAM SSF48163 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48163 TIGRFAMs TIGR00464 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00464 UniProtKB SYE_ECOLI http://www.uniprot.org/uniprot/SYE_ECOLI UniProtKB-AC P04805 http://www.uniprot.org/uniprot/P04805 charge swissprot:SYE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SYE_ECOLI eggNOG COG0008 http://eggnogapi.embl.de/nog_data/html/tree/COG0008 eggNOG ENOG4105C20 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C20 epestfind swissprot:SYE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SYE_ECOLI garnier swissprot:SYE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SYE_ECOLI helixturnhelix swissprot:SYE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SYE_ECOLI hmoment swissprot:SYE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SYE_ECOLI iep swissprot:SYE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SYE_ECOLI inforesidue swissprot:SYE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SYE_ECOLI octanol swissprot:SYE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SYE_ECOLI pepcoil swissprot:SYE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SYE_ECOLI pepdigest swissprot:SYE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SYE_ECOLI pepinfo swissprot:SYE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SYE_ECOLI pepnet swissprot:SYE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SYE_ECOLI pepstats swissprot:SYE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SYE_ECOLI pepwheel swissprot:SYE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SYE_ECOLI pepwindow swissprot:SYE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SYE_ECOLI sigcleave swissprot:SYE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SYE_ECOLI ## Database ID URL or Descriptions # BioGrid 4260653 14 # EcoGene EG13218 ybaO # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0016597 amino acid binding; IBA:GO_Central. # GO_function GO:0043565 sequence-specific DNA binding; IBA:GO_Central. # GO_process GO:0006351 transcription, DNA-templated; ISS:EcoCyc. # GO_process GO:0043200 response to amino acid; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # Gene3D 3.30.70.920 -; 1. # IntAct P0ACJ5 3 # InterPro IPR000485 AsnC-type_HTH_dom # InterPro IPR011008 Dimeric_a/b-barrel # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR019885 Tscrpt_reg_HTH_AsnC-type_CS # InterPro IPR019887 Tscrpt_reg_AsnC/Lrp_C # InterPro IPR019888 Tscrpt_reg_AsnC-typ # KEGG_Brite ko03000 Transcription factors # Organism YBAO_ECOLI Escherichia coli (strain K12) # PATRIC 32116047 VBIEscCol129921_0465 # PRINTS PR00033 HTHASNC # PROSITE PS00519 HTH_ASNC_1 # PROSITE PS50956 HTH_ASNC_2 # Pfam PF01037 AsnC_trans_reg # Pfam PF13404 HTH_AsnC-type # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBAO_ECOLI Uncharacterized HTH-type transcriptional regulator YbaO # RefSeq NP_414981 NC_000913.3 # RefSeq WP_000884589 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40203.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Contains 1 HTH asnC-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00319}. # SMART SM00344 HTH_ASNC # SUPFAM SSF46785 SSF46785 # SUPFAM SSF54909 SSF54909 # eggNOG COG1522 LUCA # eggNOG ENOG4108XM1 Bacteria BLAST swissprot:YBAO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBAO_ECOLI BioCyc ECOL316407:JW0437-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0437-MONOMER BioCyc EcoCyc:G6247-MONOMER http://biocyc.org/getid?id=EcoCyc:G6247-MONOMER COG COG1522 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1522 DIP DIP-11303N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11303N DOI 10.1016/0378-1119(93)90470-N http://dx.doi.org/10.1016/0378-1119(93)90470-N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D82943 http://www.ebi.ac.uk/ena/data/view/D82943 EMBL L08627 http://www.ebi.ac.uk/ena/data/view/L08627 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL Z54355 http://www.ebi.ac.uk/ena/data/view/Z54355 EchoBASE EB3009 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3009 EcoGene EG13218 http://www.ecogene.org/geneInfo.php?eg_id=EG13218 EnsemblBacteria AAC73550 http://www.ensemblgenomes.org/id/AAC73550 EnsemblBacteria AAC73550 http://www.ensemblgenomes.org/id/AAC73550 EnsemblBacteria BAE76227 http://www.ensemblgenomes.org/id/BAE76227 EnsemblBacteria BAE76227 http://www.ensemblgenomes.org/id/BAE76227 EnsemblBacteria BAE76227 http://www.ensemblgenomes.org/id/BAE76227 EnsemblBacteria b0447 http://www.ensemblgenomes.org/id/b0447 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0016597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016597 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0043200 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043200 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 3.30.70.920 http://www.cathdb.info/version/latest/superfamily/3.30.70.920 GeneID 945091 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945091 HOGENOM HOG000115328 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000115328&db=HOGENOM6 InParanoid P0ACJ5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACJ5 IntAct P0ACJ5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACJ5* InterPro IPR000485 http://www.ebi.ac.uk/interpro/entry/IPR000485 InterPro IPR011008 http://www.ebi.ac.uk/interpro/entry/IPR011008 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR019885 http://www.ebi.ac.uk/interpro/entry/IPR019885 InterPro IPR019887 http://www.ebi.ac.uk/interpro/entry/IPR019887 InterPro IPR019888 http://www.ebi.ac.uk/interpro/entry/IPR019888 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW0437 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0437 KEGG_Gene eco:b0447 http://www.genome.jp/dbget-bin/www_bget?eco:b0447 KEGG_Orthology KO:K05800 http://www.genome.jp/dbget-bin/www_bget?KO:K05800 OMA STTPCWK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=STTPCWK PRINTS PR00033 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00033 PROSITE PS00519 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00519 PROSITE PS50956 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50956 PSORT swissprot:YBAO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBAO_ECOLI PSORT-B swissprot:YBAO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBAO_ECOLI PSORT2 swissprot:YBAO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBAO_ECOLI Pfam PF01037 http://pfam.xfam.org/family/PF01037 Pfam PF13404 http://pfam.xfam.org/family/PF13404 Phobius swissprot:YBAO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBAO_ECOLI PhylomeDB P0ACJ5 http://phylomedb.org/?seqid=P0ACJ5 ProteinModelPortal P0ACJ5 http://www.proteinmodelportal.org/query/uniprot/P0ACJ5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7904973 http://www.ncbi.nlm.nih.gov/pubmed/7904973 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414981 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414981 RefSeq WP_000884589 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000884589 SMART SM00344 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00344 SMR P0ACJ5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACJ5 STRING 511145.b0447 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0447&targetmode=cogs STRING COG1522 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1522&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SUPFAM SSF54909 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54909 UniProtKB YBAO_ECOLI http://www.uniprot.org/uniprot/YBAO_ECOLI UniProtKB-AC P0ACJ5 http://www.uniprot.org/uniprot/P0ACJ5 charge swissprot:YBAO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBAO_ECOLI eggNOG COG1522 http://eggnogapi.embl.de/nog_data/html/tree/COG1522 eggNOG ENOG4108XM1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108XM1 epestfind swissprot:YBAO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBAO_ECOLI garnier swissprot:YBAO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBAO_ECOLI helixturnhelix swissprot:YBAO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBAO_ECOLI hmoment swissprot:YBAO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBAO_ECOLI iep swissprot:YBAO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBAO_ECOLI inforesidue swissprot:YBAO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBAO_ECOLI octanol swissprot:YBAO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBAO_ECOLI pepcoil swissprot:YBAO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBAO_ECOLI pepdigest swissprot:YBAO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBAO_ECOLI pepinfo swissprot:YBAO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBAO_ECOLI pepnet swissprot:YBAO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBAO_ECOLI pepstats swissprot:YBAO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBAO_ECOLI pepwheel swissprot:YBAO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBAO_ECOLI pepwindow swissprot:YBAO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBAO_ECOLI sigcleave swissprot:YBAO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBAO_ECOLI ## Database ID URL or Descriptions # BioGrid 4260674 269 # EcoGene EG13570 wcaB # GO_component GO:0005737 cytoplasm; IEA:InterPro. # GO_function GO:0009001 serine O-acetyltransferase activity; IEA:InterPro. # GO_function GO:0016407 acetyltransferase activity; ISS:EcoliWiki. # GO_process GO:0006535 cysteine biosynthetic process from serine; IEA:InterPro. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0045228 slime layer polysaccharide biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # InterPro IPR001451 Hexapep # InterPro IPR005881 Ser_O-AcTrfase # InterPro IPR011004 Trimer_LpxA-like # InterPro IPR018357 Hexapep_transf_CS # InterPro IPR024027 Colanic_acid_synth_WcaB # KEGG_Brite ko01000 Enzymes # Organism WCAB_ECOLI Escherichia coli (strain K12) # PATHWAY WCAB_ECOLI Slime biogenesis; slime polysaccharide biosynthesis. # PATRIC 32119449 VBIEscCol129921_2135 # PIR A64972 A64972 # PIRSF PIRSF000441 CysE # PROSITE PS00101 HEXAPEP_TRANSFERASES # Pfam PF00132 Hexapep # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName WCAB_ECOLI Putative colanic acid biosynthesis acetyltransferase WcaB # RefSeq NP_416562 NC_000913.3 # RefSeq WP_000888740 NZ_LN832404.1 # SIMILARITY Belongs to the transferase hexapeptide repeat family. {ECO 0000305}. # SUPFAM SSF51161 SSF51161 # TIGRFAMs TIGR04016 WcaB # eggNOG COG1045 LUCA # eggNOG ENOG41068PY Bacteria BLAST swissprot:WCAB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:WCAB_ECOLI BioCyc ECOL316407:JW2043-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2043-MONOMER BioCyc EcoCyc:G7103-MONOMER http://biocyc.org/getid?id=EcoCyc:G7103-MONOMER COG COG1045 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1045 DIP DIP-48109N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48109N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U38473 http://www.ebi.ac.uk/ena/data/view/U38473 ENZYME 2.3.1.- http://enzyme.expasy.org/EC/2.3.1.- EchoBASE EB3340 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3340 EcoGene EG13570 http://www.ecogene.org/geneInfo.php?eg_id=EG13570 EnsemblBacteria AAC75119 http://www.ensemblgenomes.org/id/AAC75119 EnsemblBacteria AAC75119 http://www.ensemblgenomes.org/id/AAC75119 EnsemblBacteria BAA15911 http://www.ensemblgenomes.org/id/BAA15911 EnsemblBacteria BAA15911 http://www.ensemblgenomes.org/id/BAA15911 EnsemblBacteria BAA15911 http://www.ensemblgenomes.org/id/BAA15911 EnsemblBacteria b2058 http://www.ensemblgenomes.org/id/b2058 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0009001 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009001 GO_function GO:0016407 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016407 GO_process GO:0006535 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006535 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GO_process GO:0045228 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045228 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 946573 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946573 HOGENOM HOG000049432 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000049432&db=HOGENOM6 InParanoid P0ACC9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACC9 IntAct P0ACC9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACC9* IntEnz 2.3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1 InterPro IPR001451 http://www.ebi.ac.uk/interpro/entry/IPR001451 InterPro IPR005881 http://www.ebi.ac.uk/interpro/entry/IPR005881 InterPro IPR011004 http://www.ebi.ac.uk/interpro/entry/IPR011004 InterPro IPR018357 http://www.ebi.ac.uk/interpro/entry/IPR018357 InterPro IPR024027 http://www.ebi.ac.uk/interpro/entry/IPR024027 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2043 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2043 KEGG_Gene eco:b2058 http://www.genome.jp/dbget-bin/www_bget?eco:b2058 KEGG_Orthology KO:K03819 http://www.genome.jp/dbget-bin/www_bget?KO:K03819 MINT MINT-1267537 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1267537 OMA EDCRRNA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EDCRRNA PROSITE PS00101 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00101 PSORT swissprot:WCAB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:WCAB_ECOLI PSORT-B swissprot:WCAB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:WCAB_ECOLI PSORT2 swissprot:WCAB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:WCAB_ECOLI Pfam PF00132 http://pfam.xfam.org/family/PF00132 Phobius swissprot:WCAB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:WCAB_ECOLI PhylomeDB P0ACC9 http://phylomedb.org/?seqid=P0ACC9 ProteinModelPortal P0ACC9 http://www.proteinmodelportal.org/query/uniprot/P0ACC9 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8759852 http://www.ncbi.nlm.nih.gov/pubmed/8759852 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416562 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416562 RefSeq WP_000888740 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000888740 SMR P0ACC9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACC9 STRING 511145.b2058 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2058&targetmode=cogs STRING COG1045 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1045&targetmode=cogs SUPFAM SSF51161 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51161 TIGRFAMs TIGR04016 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR04016 UniProtKB WCAB_ECOLI http://www.uniprot.org/uniprot/WCAB_ECOLI UniProtKB-AC P0ACC9 http://www.uniprot.org/uniprot/P0ACC9 charge swissprot:WCAB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:WCAB_ECOLI eggNOG COG1045 http://eggnogapi.embl.de/nog_data/html/tree/COG1045 eggNOG ENOG41068PY http://eggnogapi.embl.de/nog_data/html/tree/ENOG41068PY epestfind swissprot:WCAB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:WCAB_ECOLI garnier swissprot:WCAB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:WCAB_ECOLI helixturnhelix swissprot:WCAB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:WCAB_ECOLI hmoment swissprot:WCAB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:WCAB_ECOLI iep swissprot:WCAB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:WCAB_ECOLI inforesidue swissprot:WCAB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:WCAB_ECOLI octanol swissprot:WCAB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:WCAB_ECOLI pepcoil swissprot:WCAB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:WCAB_ECOLI pepdigest swissprot:WCAB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:WCAB_ECOLI pepinfo swissprot:WCAB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:WCAB_ECOLI pepnet swissprot:WCAB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:WCAB_ECOLI pepstats swissprot:WCAB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:WCAB_ECOLI pepwheel swissprot:WCAB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:WCAB_ECOLI pepwindow swissprot:WCAB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:WCAB_ECOLI sigcleave swissprot:WCAB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:WCAB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260673 12 # CAUTION Lacks the conserved Glu residue at position 70 that serves as proton acceptor in enzymes with gamma- glutamylcyclotransferase activity. {ECO 0000305}. # CDD cd06661 GGCT_like # EcoGene EG12516 ytfP # FUNCTION YTFP_ECOLI May play a role in antibiotic biosynthesis. {ECO 0000305}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # Gene3D 3.10.490.10 -; 1. # InterPro IPR009288 AIG2-like # InterPro IPR013024 GGCT-like # Organism YTFP_ECOLI Escherichia coli (strain K12) # PATRIC 32124021 VBIEscCol129921_4355 # PDB 1XHS NMR; -; A=1-113 # PIR S56448 S56448 # Pfam PF06094 GGACT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YTFP_ECOLI Gamma-glutamylcyclotransferase family protein YtfP # RefSeq NP_418643 NC_000913.3 # RefSeq WP_001219160 NZ_LN832404.1 # SIMILARITY Belongs to the gamma-glutamylcyclotransferase family. {ECO 0000305}. # SUPFAM SSF110857 SSF110857 # eggNOG COG2105 LUCA # eggNOG ENOG4108ZHD Bacteria BLAST swissprot:YTFP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YTFP_ECOLI BioCyc ECOL316407:JW4181-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4181-MONOMER BioCyc EcoCyc:G7876-MONOMER http://biocyc.org/getid?id=EcoCyc:G7876-MONOMER DOI 10.1002/prot.21450 http://dx.doi.org/10.1002/prot.21450 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2408 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2408 EcoGene EG12516 http://www.ecogene.org/geneInfo.php?eg_id=EG12516 EnsemblBacteria AAC77179 http://www.ensemblgenomes.org/id/AAC77179 EnsemblBacteria AAC77179 http://www.ensemblgenomes.org/id/AAC77179 EnsemblBacteria BAE78223 http://www.ensemblgenomes.org/id/BAE78223 EnsemblBacteria BAE78223 http://www.ensemblgenomes.org/id/BAE78223 EnsemblBacteria BAE78223 http://www.ensemblgenomes.org/id/BAE78223 EnsemblBacteria b4222 http://www.ensemblgenomes.org/id/b4222 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 Gene3D 3.10.490.10 http://www.cathdb.info/version/latest/superfamily/3.10.490.10 GeneID 948741 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948741 HOGENOM HOG000261862 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261862&db=HOGENOM6 InParanoid P0AE48 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AE48 IntAct P0AE48 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AE48* InterPro IPR009288 http://www.ebi.ac.uk/interpro/entry/IPR009288 InterPro IPR013024 http://www.ebi.ac.uk/interpro/entry/IPR013024 KEGG_Gene ecj:JW4181 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4181 KEGG_Gene eco:b4222 http://www.genome.jp/dbget-bin/www_bget?eco:b4222 OMA YRINSTI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YRINSTI PDB 1XHS http://www.ebi.ac.uk/pdbe-srv/view/entry/1XHS PDBsum 1XHS http://www.ebi.ac.uk/pdbsum/1XHS PSORT swissprot:YTFP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YTFP_ECOLI PSORT-B swissprot:YTFP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YTFP_ECOLI PSORT2 swissprot:YTFP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YTFP_ECOLI Pfam PF06094 http://pfam.xfam.org/family/PF06094 Phobius swissprot:YTFP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YTFP_ECOLI PhylomeDB P0AE48 http://phylomedb.org/?seqid=P0AE48 ProteinModelPortal P0AE48 http://www.proteinmodelportal.org/query/uniprot/P0AE48 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17523190 http://www.ncbi.nlm.nih.gov/pubmed/17523190 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418643 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418643 RefSeq WP_001219160 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001219160 SMR P0AE48 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AE48 STRING 511145.b4222 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4222&targetmode=cogs SUPFAM SSF110857 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF110857 UniProtKB YTFP_ECOLI http://www.uniprot.org/uniprot/YTFP_ECOLI UniProtKB-AC P0AE48 http://www.uniprot.org/uniprot/P0AE48 charge swissprot:YTFP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YTFP_ECOLI eggNOG COG2105 http://eggnogapi.embl.de/nog_data/html/tree/COG2105 eggNOG ENOG4108ZHD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZHD epestfind swissprot:YTFP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YTFP_ECOLI garnier swissprot:YTFP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YTFP_ECOLI helixturnhelix swissprot:YTFP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YTFP_ECOLI hmoment swissprot:YTFP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YTFP_ECOLI iep swissprot:YTFP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YTFP_ECOLI inforesidue swissprot:YTFP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YTFP_ECOLI octanol swissprot:YTFP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YTFP_ECOLI pepcoil swissprot:YTFP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YTFP_ECOLI pepdigest swissprot:YTFP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YTFP_ECOLI pepinfo swissprot:YTFP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YTFP_ECOLI pepnet swissprot:YTFP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YTFP_ECOLI pepstats swissprot:YTFP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YTFP_ECOLI pepwheel swissprot:YTFP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YTFP_ECOLI pepwindow swissprot:YTFP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YTFP_ECOLI sigcleave swissprot:YTFP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YTFP_ECOLI ## Database ID URL or Descriptions # AltName RNB_ECOLI Exoribonuclease II # BIOPHYSICOCHEMICAL PROPERTIES RNB_ECOLI Kinetic parameters Vmax=109800 nmol/min/mg enzyme with Poly(A) as substrate {ECO 0000269|PubMed 11948193}; Vmax=160 nmol/min/mg enzyme with 23S rRNA as substrate {ECO 0000269|PubMed 11948193}; Vmax=30 nmol/min/mg enzyme with 16S rRNA as substrate {ECO 0000269|PubMed 11948193}; Vmax=20 nmol/min/mg enzyme with 5S rRNA as substrate {ECO 0000269|PubMed 11948193}; pH dependence Optimum pH is 7.5-9.5. {ECO 0000269|PubMed 11948193}; Temperature dependence Optimum temperature is 50 degrees Celsius. {ECO 0000269|PubMed 11948193}; # BRENDA 3.1.13 2026 # BioGrid 4263341 12 # CATALYTIC ACTIVITY RNB_ECOLI Exonucleolytic cleavage in the 3'- to 5'- direction to yield nucleoside 5'-phosphates. # COFACTOR RNB_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 11948193}; # ENZYME REGULATION Stimulated by the presence of a monovalent cation. {ECO:0000269|PubMed 11948193}. # EcoGene EG11620 rnb # FUNCTION RNB_ECOLI Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction. {ECO 0000269|PubMed 11948193}. # GO_component GO:0000178 exosome (RNase complex); IBA:GO_Central. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000175 3'-5'-exoribonuclease activity; IBA:GO_Central. # GO_function GO:0003723 RNA binding; IEA:UniProtKB-KW. # GO_function GO:0008859 exoribonuclease II activity; IEA:UniProtKB-HAMAP. # GO_process GO:0006364 rRNA processing; IBA:GO_Central. # GO_process GO:0006402 mRNA catabolic process; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0004518 nuclease activity # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # HAMAP MF_01036 RNase_II # INTERACTION RNB_ECOLI P0A7W1 rpsE; NbExp=2; IntAct=EBI-557325, EBI-543949; # IntAct P30850 10 # InterPro IPR003029 S1_domain # InterPro IPR004476 RNase_II/RNase_R # InterPro IPR011129 Cold_shock_prot # InterPro IPR011804 RNase_II # InterPro IPR012340 NA-bd_OB-fold # InterPro IPR013223 RNase_B_OB_dom # InterPro IPR022966 RNase_II/R_CS # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # Organism RNB_ECOLI Escherichia coli (strain K12) # PATRIC 32117840 VBIEscCol129921_1340 # PDB 2ID0 X-ray; 2.35 A; A/B/C/D=1-644 # PDB 2IX0 X-ray; 2.44 A; A=6-644 # PDB 2IX1 X-ray; 2.74 A; A=6-644 # PIR A64877 A64877 # PROSITE PS01175 RIBONUCLEASE_II # Pfam PF00575 S1 # Pfam PF08206 OB_RNB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RNB_ECOLI Exoribonuclease 2 # RefSeq NP_415802 NC_000913.3 # RefSeq WP_000484984 NZ_LN832404.1 # SIMILARITY Belongs to the RNR ribonuclease family. RNase II subfamily. {ECO 0000305}. # SIMILARITY Contains 1 S1 motif domain. {ECO 0000305}. # SMART SM00357 CSP # SUBCELLULAR LOCATION RNB_ECOLI Cytoplasm. # SUPFAM SSF50249 SSF50249; 4 # TIGRFAMs TIGR00358 3_prime_RNase # TIGRFAMs TIGR02062 RNase_B # eggNOG COG4776 LUCA # eggNOG ENOG4108IEC Bacteria BLAST swissprot:RNB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RNB_ECOLI BioCyc ECOL316407:JW1279-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1279-MONOMER BioCyc EcoCyc:EG11620-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11620-MONOMER BioCyc MetaCyc:EG11620-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11620-MONOMER COG COG0557 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0557 DIP DIP-10724N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10724N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M202942200 http://dx.doi.org/10.1074/jbc.M202942200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1111/j.1365-2958.1993.tb01201.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb01201.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.13.1 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.13.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X67913 http://www.ebi.ac.uk/ena/data/view/X67913 ENZYME 3.1.13.1 http://enzyme.expasy.org/EC/3.1.13.1 EchoBASE EB1577 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1577 EcoGene EG11620 http://www.ecogene.org/geneInfo.php?eg_id=EG11620 EnsemblBacteria AAC74368 http://www.ensemblgenomes.org/id/AAC74368 EnsemblBacteria AAC74368 http://www.ensemblgenomes.org/id/AAC74368 EnsemblBacteria BAA14840 http://www.ensemblgenomes.org/id/BAA14840 EnsemblBacteria BAA14840 http://www.ensemblgenomes.org/id/BAA14840 EnsemblBacteria BAA14840 http://www.ensemblgenomes.org/id/BAA14840 EnsemblBacteria b1286 http://www.ensemblgenomes.org/id/b1286 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0000178 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000178 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000175 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000175 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0008859 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008859 GO_process GO:0006364 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006364 GO_process GO:0006402 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006402 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 GeneID 945864 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945864 HAMAP MF_01036 http://hamap.expasy.org/unirule/MF_01036 HOGENOM HOG000271427 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000271427&db=HOGENOM6 InParanoid P30850 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30850 IntAct P30850 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P30850* IntEnz 3.1.13.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.13.1 InterPro IPR003029 http://www.ebi.ac.uk/interpro/entry/IPR003029 InterPro IPR004476 http://www.ebi.ac.uk/interpro/entry/IPR004476 InterPro IPR011129 http://www.ebi.ac.uk/interpro/entry/IPR011129 InterPro IPR011804 http://www.ebi.ac.uk/interpro/entry/IPR011804 InterPro IPR012340 http://www.ebi.ac.uk/interpro/entry/IPR012340 InterPro IPR013223 http://www.ebi.ac.uk/interpro/entry/IPR013223 InterPro IPR022966 http://www.ebi.ac.uk/interpro/entry/IPR022966 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW1279 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1279 KEGG_Gene eco:b1286 http://www.genome.jp/dbget-bin/www_bget?eco:b1286 KEGG_Orthology KO:K01147 http://www.genome.jp/dbget-bin/www_bget?KO:K01147 MINT MINT-1248196 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1248196 OMA ICLSRGE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ICLSRGE PDB 2ID0 http://www.ebi.ac.uk/pdbe-srv/view/entry/2ID0 PDB 2IX0 http://www.ebi.ac.uk/pdbe-srv/view/entry/2IX0 PDB 2IX1 http://www.ebi.ac.uk/pdbe-srv/view/entry/2IX1 PDBsum 2ID0 http://www.ebi.ac.uk/pdbsum/2ID0 PDBsum 2IX0 http://www.ebi.ac.uk/pdbsum/2IX0 PDBsum 2IX1 http://www.ebi.ac.uk/pdbsum/2IX1 PROSITE PS01175 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01175 PSORT swissprot:RNB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RNB_ECOLI PSORT-B swissprot:RNB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RNB_ECOLI PSORT2 swissprot:RNB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RNB_ECOLI Pfam PF00575 http://pfam.xfam.org/family/PF00575 Pfam PF08206 http://pfam.xfam.org/family/PF08206 Phobius swissprot:RNB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RNB_ECOLI PhylomeDB P30850 http://phylomedb.org/?seqid=P30850 ProteinModelPortal P30850 http://www.proteinmodelportal.org/query/uniprot/P30850 PubMed 11948193 http://www.ncbi.nlm.nih.gov/pubmed/11948193 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8497196 http://www.ncbi.nlm.nih.gov/pubmed/8497196 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415802 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415802 RefSeq WP_000484984 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000484984 SMART SM00357 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00357 SMR P30850 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P30850 STRING 511145.b1286 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1286&targetmode=cogs STRING COG0557 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0557&targetmode=cogs SUPFAM SSF50249 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50249 TIGRFAMs TIGR00358 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00358 TIGRFAMs TIGR02062 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02062 UniProtKB RNB_ECOLI http://www.uniprot.org/uniprot/RNB_ECOLI UniProtKB-AC P30850 http://www.uniprot.org/uniprot/P30850 charge swissprot:RNB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RNB_ECOLI eggNOG COG4776 http://eggnogapi.embl.de/nog_data/html/tree/COG4776 eggNOG ENOG4108IEC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108IEC epestfind swissprot:RNB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RNB_ECOLI garnier swissprot:RNB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RNB_ECOLI helixturnhelix swissprot:RNB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RNB_ECOLI hmoment swissprot:RNB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RNB_ECOLI iep swissprot:RNB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RNB_ECOLI inforesidue swissprot:RNB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RNB_ECOLI octanol swissprot:RNB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RNB_ECOLI pepcoil swissprot:RNB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RNB_ECOLI pepdigest swissprot:RNB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RNB_ECOLI pepinfo swissprot:RNB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RNB_ECOLI pepnet swissprot:RNB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RNB_ECOLI pepstats swissprot:RNB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RNB_ECOLI pepwheel swissprot:RNB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RNB_ECOLI pepwindow swissprot:RNB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RNB_ECOLI sigcleave swissprot:RNB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RNB_ECOLI ## Database ID URL or Descriptions # BioGrid 4262930 7 # EcoGene EG14214 hyfF # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; ISA:EcoliWiki. # GO_function GO:0016491 oxidoreductase activity; IEA:UniProtKB-KW. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006950 response to stress # InterPro IPR001516 Proton_antipo_N # InterPro IPR001750 ND/Mrp_mem # KEGG_Brite ko01000 Enzymes # Organism HYFF_ECOLI Escherichia coli (strain K12) # PATRIC 32120359 VBIEscCol129921_2582 # PIR E65024 E65024 # Pfam PF00361 Proton_antipo_M # Pfam PF00662 Proton_antipo_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HYFF_ECOLI Hydrogenase-4 component F # RefSeq NP_416981 NC_000913.3 # RefSeq WP_000122577 NZ_LN832404.1 # SIMILARITY Belongs to the complex I subunit 5 family. {ECO 0000305}. # SUBCELLULAR LOCATION HYFF_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # TCDB 3.D.1.9 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family # eggNOG COG0651 LUCA # eggNOG ENOG4108JPZ Bacteria BLAST swissprot:HYFF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HYFF_ECOLI BioCyc ECOL316407:JW2471-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2471-MONOMER BioCyc EcoCyc:MONOMER0-143 http://biocyc.org/getid?id=EcoCyc:MONOMER0-143 COG COG0651 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0651 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M63654 http://www.ebi.ac.uk/ena/data/view/M63654 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- EchoBASE EB3966 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3966 EcoGene EG14214 http://www.ecogene.org/geneInfo.php?eg_id=EG14214 EnsemblBacteria AAC75539 http://www.ensemblgenomes.org/id/AAC75539 EnsemblBacteria AAC75539 http://www.ensemblgenomes.org/id/AAC75539 EnsemblBacteria BAA16374 http://www.ensemblgenomes.org/id/BAA16374 EnsemblBacteria BAA16374 http://www.ensemblgenomes.org/id/BAA16374 EnsemblBacteria BAA16374 http://www.ensemblgenomes.org/id/BAA16374 EnsemblBacteria b2486 http://www.ensemblgenomes.org/id/b2486 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 946962 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946962 HOGENOM HOG000020533 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000020533&db=HOGENOM6 InParanoid P77437 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77437 IntAct P77437 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77437* IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR001516 http://www.ebi.ac.uk/interpro/entry/IPR001516 InterPro IPR001750 http://www.ebi.ac.uk/interpro/entry/IPR001750 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2471 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2471 KEGG_Gene eco:b2486 http://www.genome.jp/dbget-bin/www_bget?eco:b2486 KEGG_Orthology KO:K12141 http://www.genome.jp/dbget-bin/www_bget?KO:K12141 OMA LAYMACT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LAYMACT PSORT swissprot:HYFF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HYFF_ECOLI PSORT-B swissprot:HYFF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HYFF_ECOLI PSORT2 swissprot:HYFF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HYFF_ECOLI Pfam PF00361 http://pfam.xfam.org/family/PF00361 Pfam PF00662 http://pfam.xfam.org/family/PF00662 Phobius swissprot:HYFF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HYFF_ECOLI PhylomeDB P77437 http://phylomedb.org/?seqid=P77437 ProteinModelPortal P77437 http://www.proteinmodelportal.org/query/uniprot/P77437 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416981 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416981 RefSeq WP_000122577 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000122577 STRING 511145.b2486 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2486&targetmode=cogs STRING COG0651 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0651&targetmode=cogs TCDB 3.D.1.9 http://www.tcdb.org/search/result.php?tc=3.D.1.9 UniProtKB HYFF_ECOLI http://www.uniprot.org/uniprot/HYFF_ECOLI UniProtKB-AC P77437 http://www.uniprot.org/uniprot/P77437 charge swissprot:HYFF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HYFF_ECOLI eggNOG COG0651 http://eggnogapi.embl.de/nog_data/html/tree/COG0651 eggNOG ENOG4108JPZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108JPZ epestfind swissprot:HYFF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HYFF_ECOLI garnier swissprot:HYFF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HYFF_ECOLI helixturnhelix swissprot:HYFF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HYFF_ECOLI hmoment swissprot:HYFF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HYFF_ECOLI iep swissprot:HYFF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HYFF_ECOLI inforesidue swissprot:HYFF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HYFF_ECOLI octanol swissprot:HYFF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HYFF_ECOLI pepcoil swissprot:HYFF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HYFF_ECOLI pepdigest swissprot:HYFF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HYFF_ECOLI pepinfo swissprot:HYFF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HYFF_ECOLI pepnet swissprot:HYFF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HYFF_ECOLI pepstats swissprot:HYFF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HYFF_ECOLI pepwheel swissprot:HYFF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HYFF_ECOLI pepwindow swissprot:HYFF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HYFF_ECOLI sigcleave swissprot:HYFF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HYFF_ECOLI ## Database ID URL or Descriptions # AltName INTF_ECOLI Putative prophage CP4-6 integrase # BioGrid 4259784 10 # EcoGene EG13554 intF # FUNCTION INTF_ECOLI Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome. # GO_function GO:0008979 prophage integrase activity; IBA:GO_Central. # GO_function GO:0043565 sequence-specific DNA binding; IBA:GO_Central. # GO_process GO:0006310 DNA recombination; IEA:UniProtKB-KW. # GO_process GO:0032359 provirus excision; IBA:GO_Central. # GO_process GO:0046718 viral entry into host cell; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0044403 symbiosis, encompassing mutualism through parasitism # Gene3D 1.10.443.10 -; 1. # InterPro IPR002104 Integrase_catalytic # InterPro IPR011010 DNA_brk_join_enz # InterPro IPR013762 Integrase-like_cat # InterPro IPR025166 DUF4102 # Organism INTF_ECOLI Escherichia coli (strain K12) # PATRIC 32115683 VBIEscCol129921_0285 # PIR A64754 A64754 # Pfam PF00589 Phage_integrase # Pfam PF13356 DUF4102 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Prophage integrase IntF {ECO 0000305} # RefSeq NP_414815 NC_000913.3 # SIMILARITY Belongs to the 'phage' integrase family. {ECO 0000305}. # SUPFAM SSF56349 SSF56349 # eggNOG COG0582 LUCA # eggNOG ENOG41067CV Bacteria BLAST swissprot:INTF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INTF_ECOLI BioCyc ECOL316407:JW0275-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0275-MONOMER BioCyc EcoCyc:G6152-MONOMER http://biocyc.org/getid?id=EcoCyc:G6152-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB3324 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3324 EcoGene EG13554 http://www.ecogene.org/geneInfo.php?eg_id=EG13554 EnsemblBacteria AAC73384 http://www.ensemblgenomes.org/id/AAC73384 EnsemblBacteria AAC73384 http://www.ensemblgenomes.org/id/AAC73384 EnsemblBacteria BAE76065 http://www.ensemblgenomes.org/id/BAE76065 EnsemblBacteria BAE76065 http://www.ensemblgenomes.org/id/BAE76065 EnsemblBacteria BAE76065 http://www.ensemblgenomes.org/id/BAE76065 EnsemblBacteria b0281 http://www.ensemblgenomes.org/id/b0281 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008979 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0032359 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032359 GO_process GO:0046718 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046718 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0044403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403 Gene3D 1.10.443.10 http://www.cathdb.info/version/latest/superfamily/1.10.443.10 GeneID 947351 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947351 HOGENOM HOG000258764 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000258764&db=HOGENOM6 InParanoid P71298 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P71298 IntAct P71298 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P71298* InterPro IPR002104 http://www.ebi.ac.uk/interpro/entry/IPR002104 InterPro IPR011010 http://www.ebi.ac.uk/interpro/entry/IPR011010 InterPro IPR013762 http://www.ebi.ac.uk/interpro/entry/IPR013762 InterPro IPR025166 http://www.ebi.ac.uk/interpro/entry/IPR025166 KEGG_Gene ecj:JW0275 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0275 KEGG_Gene eco:b0281 http://www.genome.jp/dbget-bin/www_bget?eco:b0281 OMA DFRWRSL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DFRWRSL PSORT swissprot:INTF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INTF_ECOLI PSORT-B swissprot:INTF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INTF_ECOLI PSORT2 swissprot:INTF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INTF_ECOLI Pfam PF00589 http://pfam.xfam.org/family/PF00589 Pfam PF13356 http://pfam.xfam.org/family/PF13356 Phobius swissprot:INTF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INTF_ECOLI ProteinModelPortal P71298 http://www.proteinmodelportal.org/query/uniprot/P71298 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414815 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414815 SMR P71298 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P71298 STRING 511145.b0281 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0281&targetmode=cogs SUPFAM SSF56349 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56349 UniProtKB INTF_ECOLI http://www.uniprot.org/uniprot/INTF_ECOLI UniProtKB-AC P71298 http://www.uniprot.org/uniprot/P71298 charge swissprot:INTF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INTF_ECOLI eggNOG COG0582 http://eggnogapi.embl.de/nog_data/html/tree/COG0582 eggNOG ENOG41067CV http://eggnogapi.embl.de/nog_data/html/tree/ENOG41067CV epestfind swissprot:INTF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INTF_ECOLI garnier swissprot:INTF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INTF_ECOLI helixturnhelix swissprot:INTF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INTF_ECOLI hmoment swissprot:INTF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INTF_ECOLI iep swissprot:INTF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INTF_ECOLI inforesidue swissprot:INTF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INTF_ECOLI octanol swissprot:INTF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INTF_ECOLI pepcoil swissprot:INTF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INTF_ECOLI pepdigest swissprot:INTF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INTF_ECOLI pepinfo swissprot:INTF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INTF_ECOLI pepnet swissprot:INTF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INTF_ECOLI pepstats swissprot:INTF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INTF_ECOLI pepwheel swissprot:INTF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INTF_ECOLI pepwindow swissprot:INTF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INTF_ECOLI sigcleave swissprot:INTF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INTF_ECOLI ## Database ID URL or Descriptions # BioGrid 4262637 6 # EcoGene EG11844 yihR # GO_function GO:0004034 aldose 1-epimerase activity; IBA:GO_Central. # GO_function GO:0030246 carbohydrate binding; IEA:InterPro. # GO_process GO:0006006 glucose metabolic process; IBA:GO_Central. # GO_process GO:0033499 galactose catabolic process via UDP-galactose; IBA:GO_Central. # GO_process GO:0044010 single-species biofilm formation; IMP:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 2.70.98.10 -; 1. # INDUCTION Induced during growth with sulfoquinovose. {ECO:0000269|PubMed 24463506}. # IntAct P32139 2 # InterPro IPR008183 Aldose_1/G6P_1-epimerase # InterPro IPR011013 Gal_mutarotase_SF_dom # InterPro IPR014718 GH-type_carb-bd # Organism YIHR_ECOLI Escherichia coli (strain K12) # PATRIC 32123261 VBIEscCol129921_3991 # PIR S40823 S40823 # Pfam PF01263 Aldose_epim # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIHR_ECOLI Uncharacterized protein YihR # RefSeq NP_418315 NC_000913.3 # SUPFAM SSF74650 SSF74650 # eggNOG COG2017 LUCA # eggNOG ENOG4107WI4 Bacteria BLAST swissprot:YIHR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIHR_ECOLI BioCyc ECOL316407:JW3850-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3850-MONOMER BioCyc EcoCyc:EG11844-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11844-MONOMER DIP DIP-12499N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12499N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature12947 http://dx.doi.org/10.1038/nature12947 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1790 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1790 EcoGene EG11844 http://www.ecogene.org/geneInfo.php?eg_id=EG11844 EnsemblBacteria AAC76876 http://www.ensemblgenomes.org/id/AAC76876 EnsemblBacteria AAC76876 http://www.ensemblgenomes.org/id/AAC76876 EnsemblBacteria BAE77430 http://www.ensemblgenomes.org/id/BAE77430 EnsemblBacteria BAE77430 http://www.ensemblgenomes.org/id/BAE77430 EnsemblBacteria BAE77430 http://www.ensemblgenomes.org/id/BAE77430 EnsemblBacteria b3879 http://www.ensemblgenomes.org/id/b3879 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004034 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004034 GO_function GO:0030246 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030246 GO_process GO:0006006 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006006 GO_process GO:0033499 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033499 GO_process GO:0044010 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044010 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 2.70.98.10 http://www.cathdb.info/version/latest/superfamily/2.70.98.10 GeneID 948375 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948375 HOGENOM HOG000241112 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000241112&db=HOGENOM6 InParanoid P32139 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32139 IntAct P32139 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32139* InterPro IPR008183 http://www.ebi.ac.uk/interpro/entry/IPR008183 InterPro IPR011013 http://www.ebi.ac.uk/interpro/entry/IPR011013 InterPro IPR014718 http://www.ebi.ac.uk/interpro/entry/IPR014718 KEGG_Gene ecj:JW3850 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3850 KEGG_Gene eco:b3879 http://www.genome.jp/dbget-bin/www_bget?eco:b3879 MINT MINT-1315965 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1315965 OMA NIDLIRP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NIDLIRP PSORT swissprot:YIHR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIHR_ECOLI PSORT-B swissprot:YIHR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIHR_ECOLI PSORT2 swissprot:YIHR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIHR_ECOLI Pfam PF01263 http://pfam.xfam.org/family/PF01263 Phobius swissprot:YIHR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIHR_ECOLI PhylomeDB P32139 http://phylomedb.org/?seqid=P32139 ProteinModelPortal P32139 http://www.proteinmodelportal.org/query/uniprot/P32139 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 24463506 http://www.ncbi.nlm.nih.gov/pubmed/24463506 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418315 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418315 SMR P32139 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32139 STRING 511145.b3879 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3879&targetmode=cogs SUPFAM SSF74650 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF74650 UniProtKB YIHR_ECOLI http://www.uniprot.org/uniprot/YIHR_ECOLI UniProtKB-AC P32139 http://www.uniprot.org/uniprot/P32139 charge swissprot:YIHR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIHR_ECOLI eggNOG COG2017 http://eggnogapi.embl.de/nog_data/html/tree/COG2017 eggNOG ENOG4107WI4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107WI4 epestfind swissprot:YIHR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIHR_ECOLI garnier swissprot:YIHR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIHR_ECOLI helixturnhelix swissprot:YIHR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIHR_ECOLI hmoment swissprot:YIHR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIHR_ECOLI iep swissprot:YIHR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIHR_ECOLI inforesidue swissprot:YIHR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIHR_ECOLI octanol swissprot:YIHR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIHR_ECOLI pepcoil swissprot:YIHR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIHR_ECOLI pepdigest swissprot:YIHR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIHR_ECOLI pepinfo swissprot:YIHR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIHR_ECOLI pepnet swissprot:YIHR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIHR_ECOLI pepstats swissprot:YIHR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIHR_ECOLI pepwheel swissprot:YIHR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIHR_ECOLI pepwindow swissprot:YIHR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIHR_ECOLI sigcleave swissprot:YIHR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIHR_ECOLI ## Database ID URL or Descriptions # AltName HDEA_ECOLI 10K-S protein # BioGrid 4262518 3 # EcoGene EG11398 hdeA # FUNCTION HDEA_ECOLI Required for optimal acid stress protection. Exhibits a chaperone-like activity only at pH below 3 by suppressing non- specifically the aggregation of denaturated periplasmic proteins. Important for survival of enteric bacteria in the acidic environment of the host stomach. Also promotes the solubilization at neutral pH of proteins that had aggregated in their presence at acidic pHs. May cooperate with other periplasmic chaperones such as DegP and SurA. {ECO 0000269|PubMed 15911614, ECO 0000269|PubMed 17085547, ECO 0000269|PubMed 18359765, ECO 0000269|PubMed 21892184}. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IEA:InterPro. # GO_function GO:0051087 chaperone binding; IDA:EcoCyc. # GO_process GO:0033554 cellular response to stress; IEA:UniProtKB-HAMAP. # GO_process GO:0071468 cellular response to acidic pH; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # Gene3D 1.10.890.10 -; 1. # HAMAP MF_00946 HdeA # INDUCTION HDEA_ECOLI Activated by a low pH-induced dimer-to-monomer transition. # InterPro IPR010486 HNS-dep_expression_A/B # InterPro IPR024972 HdeA # MASS SPECTROMETRY Mass=9742; Method=Electrospray; Range=22-110; Evidence={ECO:0000269|PubMed 12071744}; # MISCELLANEOUS In vitro, HdeA is more efficient than HdeB at pH 2 and HdeB is more efficient than HdeA at pH 3. In vivo, both are required for optimal protection against acid stress at either pH 3 or pH 2 (PubMed:17085547). {ECO 0000305|PubMed:17085547}. # Organism HDEA_ECOLI Escherichia coli (strain K12) # PATRIC 32122478 VBIEscCol129921_3617 # PDB 1BG8 X-ray; 2.20 A; A/B/C=22-110 # PDB 1DJ8 X-ray; 2.00 A; A/B/C/D/E/F=22-110 # PIR S30268 S30268 # PIRSF PIRSF009564 HNS-dep_expression_A # Pfam PF06411 HdeA # ProDom PD065392 HNS-dep_expression_A # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Acid stress chaperone HdeA {ECO:0000255|HAMAP-Rule MF_00946} # RefSeq NP_417967 NC_000913.3 # RefSeq WP_000756550 NZ_LN832404.1 # SIMILARITY Belongs to the HdeA family. {ECO:0000255|HAMAP- Rule MF_00946}. # SUBCELLULAR LOCATION HDEA_ECOLI Periplasm {ECO 0000255|HAMAP-Rule MF_00946, ECO 0000269|PubMed 17085547}. # SUBUNIT Homodimer at neutral pH. Dissociates into monomer at pH 4. Changes from a highly ordered form at pH above 3.1 to a highly disordered form at pH below 2.5 that is essential for its chaperone activity. {ECO:0000269|PubMed 10623550}. # SUPFAM SSF47752 SSF47752 # eggNOG ENOG41060V2 Bacteria # eggNOG ENOG41128BT LUCA BLAST swissprot:HDEA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HDEA_ECOLI BioCyc ECOL316407:JW3478-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3478-MONOMER BioCyc EcoCyc:EG11398-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11398-MONOMER DIP DIP-47945N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47945N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1999.3347 http://dx.doi.org/10.1006/jmbi.1999.3347 DOI 10.1007/BF00282791 http://dx.doi.org/10.1007/BF00282791 DOI 10.1021/ja025966k http://dx.doi.org/10.1021/ja025966k DOI 10.1038/1796 http://dx.doi.org/10.1038/1796 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nchembio.644 http://dx.doi.org/10.1038/nchembio.644 DOI 10.1074/jbc.M503934200 http://dx.doi.org/10.1074/jbc.M503934200 DOI 10.1074/jbc.M800869200 http://dx.doi.org/10.1074/jbc.M800869200 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1111/j.1574-6968.1998.tb13343.x http://dx.doi.org/10.1111/j.1574-6968.1998.tb13343.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01522-06 http://dx.doi.org/10.1128/JB.01522-06 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D11109 http://www.ebi.ac.uk/ena/data/view/D11109 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1370 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1370 EcoGene EG11398 http://www.ecogene.org/geneInfo.php?eg_id=EG11398 EnsemblBacteria AAC76535 http://www.ensemblgenomes.org/id/AAC76535 EnsemblBacteria AAC76535 http://www.ensemblgenomes.org/id/AAC76535 EnsemblBacteria BAE77784 http://www.ensemblgenomes.org/id/BAE77784 EnsemblBacteria BAE77784 http://www.ensemblgenomes.org/id/BAE77784 EnsemblBacteria BAE77784 http://www.ensemblgenomes.org/id/BAE77784 EnsemblBacteria b3510 http://www.ensemblgenomes.org/id/b3510 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0051087 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051087 GO_process GO:0033554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033554 GO_process GO:0071468 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071468 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.10.890.10 http://www.cathdb.info/version/latest/superfamily/1.10.890.10 GeneID 948025 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948025 HAMAP MF_00946 http://hamap.expasy.org/unirule/MF_00946 HOGENOM HOG000125826 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125826&db=HOGENOM6 InterPro IPR010486 http://www.ebi.ac.uk/interpro/entry/IPR010486 InterPro IPR024972 http://www.ebi.ac.uk/interpro/entry/IPR024972 KEGG_Gene ecj:JW3478 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3478 KEGG_Gene eco:b3510 http://www.genome.jp/dbget-bin/www_bget?eco:b3510 OMA VESEWEK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VESEWEK PDB 1BG8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1BG8 PDB 1DJ8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1DJ8 PDBsum 1BG8 http://www.ebi.ac.uk/pdbsum/1BG8 PDBsum 1DJ8 http://www.ebi.ac.uk/pdbsum/1DJ8 PSORT swissprot:HDEA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HDEA_ECOLI PSORT-B swissprot:HDEA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HDEA_ECOLI PSORT2 swissprot:HDEA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HDEA_ECOLI Pfam PF06411 http://pfam.xfam.org/family/PF06411 Phobius swissprot:HDEA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HDEA_ECOLI ProteinModelPortal P0AES9 http://www.proteinmodelportal.org/query/uniprot/P0AES9 PubMed 10623550 http://www.ncbi.nlm.nih.gov/pubmed/10623550 PubMed 12071744 http://www.ncbi.nlm.nih.gov/pubmed/12071744 PubMed 15911614 http://www.ncbi.nlm.nih.gov/pubmed/15911614 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17085547 http://www.ncbi.nlm.nih.gov/pubmed/17085547 PubMed 18359765 http://www.ncbi.nlm.nih.gov/pubmed/18359765 PubMed 21892184 http://www.ncbi.nlm.nih.gov/pubmed/21892184 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 8244952 http://www.ncbi.nlm.nih.gov/pubmed/8244952 PubMed 8455549 http://www.ncbi.nlm.nih.gov/pubmed/8455549 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9731767 http://www.ncbi.nlm.nih.gov/pubmed/9731767 PubMed 9868784 http://www.ncbi.nlm.nih.gov/pubmed/9868784 RefSeq NP_417967 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417967 RefSeq WP_000756550 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000756550 SMR P0AES9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AES9 STRING 511145.b3510 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3510&targetmode=cogs SUPFAM SSF47752 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47752 SWISS-2DPAGE P0AES9 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AES9 UniProtKB HDEA_ECOLI http://www.uniprot.org/uniprot/HDEA_ECOLI UniProtKB-AC P0AES9 http://www.uniprot.org/uniprot/P0AES9 charge swissprot:HDEA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HDEA_ECOLI eggNOG ENOG41060V2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41060V2 eggNOG ENOG41128BT http://eggnogapi.embl.de/nog_data/html/tree/ENOG41128BT epestfind swissprot:HDEA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HDEA_ECOLI garnier swissprot:HDEA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HDEA_ECOLI helixturnhelix swissprot:HDEA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HDEA_ECOLI hmoment swissprot:HDEA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HDEA_ECOLI iep swissprot:HDEA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HDEA_ECOLI inforesidue swissprot:HDEA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HDEA_ECOLI octanol swissprot:HDEA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HDEA_ECOLI pepcoil swissprot:HDEA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HDEA_ECOLI pepdigest swissprot:HDEA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HDEA_ECOLI pepinfo swissprot:HDEA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HDEA_ECOLI pepnet swissprot:HDEA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HDEA_ECOLI pepstats swissprot:HDEA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HDEA_ECOLI pepwheel swissprot:HDEA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HDEA_ECOLI pepwindow swissprot:HDEA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HDEA_ECOLI sigcleave swissprot:HDEA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HDEA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261095 10 # CAUTION Was originally (Ref.4) thought to originate from Proteus vulgaris, but was shown to originate from E.coli. {ECO:0000305|PubMed 9079933}. # CDD cd01948 EAL # EcoGene EG14077 rtn # FUNCTION RTN_ECOLI Involved in resistance to phages N4 and lambda. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # Gene3D 3.20.20.450 -; 1. # INDUCTION Expressed at both 28 and 37 degrees Celsius during exponential growth. Repressed by RpoS. {ECO:0000269|PubMed 19332833}. # InterPro IPR001633 EAL_dom # InterPro IPR024744 CSS-motif_dom # Organism RTN_ECOLI Escherichia coli (strain K12) # PATRIC 32119707 VBIEscCol129921_2264 # PIR G64986 G64986 # PROSITE PS50883 EAL # Pfam PF00563 EAL # Pfam PF12792 CSS-motif # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RTN_ECOLI Protein Rtn # RefSeq NP_416681 NC_000913.3 # RefSeq WP_000470560 NZ_LN832404.1 # SIMILARITY Contains 1 EAL domain. {ECO:0000255|PROSITE- ProRule PRU00074}. # SMART SM00052 EAL # SUBCELLULAR LOCATION RTN_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # SUPFAM SSF141868 SSF141868 # eggNOG COG2200 LUCA # eggNOG ENOG4105CXC Bacteria BLAST swissprot:RTN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RTN_ECOLI BioCyc ECOL316407:JW2164-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2164-MONOMER BioCyc EcoCyc:G7148-MONOMER http://biocyc.org/getid?id=EcoCyc:G7148-MONOMER DIP DIP-10813N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10813N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1099/mic.0.024257-0 http://dx.doi.org/10.1099/mic.0.024257-0 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U12780 http://www.ebi.ac.uk/ena/data/view/U12780 EMBL U83404 http://www.ebi.ac.uk/ena/data/view/U83404 EchoBASE EB3830 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3830 EcoGene EG14077 http://www.ecogene.org/geneInfo.php?eg_id=EG14077 EnsemblBacteria AAC75237 http://www.ensemblgenomes.org/id/AAC75237 EnsemblBacteria AAC75237 http://www.ensemblgenomes.org/id/AAC75237 EnsemblBacteria BAA15984 http://www.ensemblgenomes.org/id/BAA15984 EnsemblBacteria BAA15984 http://www.ensemblgenomes.org/id/BAA15984 EnsemblBacteria BAA15984 http://www.ensemblgenomes.org/id/BAA15984 EnsemblBacteria b2176 http://www.ensemblgenomes.org/id/b2176 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 Gene3D 3.20.20.450 http://www.cathdb.info/version/latest/superfamily/3.20.20.450 GeneID 946695 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946695 HOGENOM HOG000273106 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000273106&db=HOGENOM6 InParanoid P76446 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76446 InterPro IPR001633 http://www.ebi.ac.uk/interpro/entry/IPR001633 InterPro IPR024744 http://www.ebi.ac.uk/interpro/entry/IPR024744 KEGG_Gene ecj:JW2164 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2164 KEGG_Gene eco:b2176 http://www.genome.jp/dbget-bin/www_bget?eco:b2176 OMA QLYADSW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QLYADSW PROSITE PS50883 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50883 PSORT swissprot:RTN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RTN_ECOLI PSORT-B swissprot:RTN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RTN_ECOLI PSORT2 swissprot:RTN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RTN_ECOLI Pfam PF00563 http://pfam.xfam.org/family/PF00563 Pfam PF12792 http://pfam.xfam.org/family/PF12792 Phobius swissprot:RTN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RTN_ECOLI PhylomeDB P76446 http://phylomedb.org/?seqid=P76446 ProteinModelPortal P76446 http://www.proteinmodelportal.org/query/uniprot/P76446 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19332833 http://www.ncbi.nlm.nih.gov/pubmed/19332833 PubMed 9079933 http://www.ncbi.nlm.nih.gov/pubmed/9079933 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416681 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416681 RefSeq WP_000470560 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000470560 SMART SM00052 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00052 SMR P76446 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76446 STRING 511145.b2176 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2176&targetmode=cogs SUPFAM SSF141868 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF141868 UniProtKB RTN_ECOLI http://www.uniprot.org/uniprot/RTN_ECOLI UniProtKB-AC P76446 http://www.uniprot.org/uniprot/P76446 charge swissprot:RTN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RTN_ECOLI eggNOG COG2200 http://eggnogapi.embl.de/nog_data/html/tree/COG2200 eggNOG ENOG4105CXC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CXC epestfind swissprot:RTN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RTN_ECOLI garnier swissprot:RTN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RTN_ECOLI helixturnhelix swissprot:RTN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RTN_ECOLI hmoment swissprot:RTN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RTN_ECOLI iep swissprot:RTN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RTN_ECOLI inforesidue swissprot:RTN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RTN_ECOLI octanol swissprot:RTN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RTN_ECOLI pepcoil swissprot:RTN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RTN_ECOLI pepdigest swissprot:RTN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RTN_ECOLI pepinfo swissprot:RTN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RTN_ECOLI pepnet swissprot:RTN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RTN_ECOLI pepstats swissprot:RTN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RTN_ECOLI pepwheel swissprot:RTN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RTN_ECOLI pepwindow swissprot:RTN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RTN_ECOLI sigcleave swissprot:RTN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RTN_ECOLI ## Database ID URL or Descriptions # BioGrid 4260663 7 # EcoGene EG13650 ybeT # Gene3D 1.25.40.10 -; 1. # INDUCTION Repressed by the toxin-antitoxin module MqsR-MqsA. {ECO:0000269|PubMed 25534751}. # InterPro IPR006597 Sel1-like # InterPro IPR011990 TPR-like_helical_dom # Organism YBET_ECOLI Escherichia coli (strain K12) # PATRIC 32116477 VBIEscCol129921_0678 # PIR E64799 E64799 # Pfam PF08238 Sel1; 3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBET_ECOLI Uncharacterized protein YbeT # RefSeq NP_415180 NC_000913.3 # RefSeq WP_001035674 NZ_LN832404.1 # SIMILARITY To E.coli YbeQ. {ECO 0000305}. # SMART SM00671 SEL1; 3 # eggNOG COG0790 LUCA # eggNOG ENOG4107JFD Bacteria BLAST swissprot:YBET_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBET_ECOLI BioCyc ECOL316407:JW0642-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0642-MONOMER BioCyc EcoCyc:G6354-MONOMER http://biocyc.org/getid?id=EcoCyc:G6354-MONOMER COG COG0790 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0790 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/1462-2920.12749 http://dx.doi.org/10.1111/1462-2920.12749 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB3414 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3414 EcoGene EG13650 http://www.ecogene.org/geneInfo.php?eg_id=EG13650 EnsemblBacteria AAC73748 http://www.ensemblgenomes.org/id/AAC73748 EnsemblBacteria AAC73748 http://www.ensemblgenomes.org/id/AAC73748 EnsemblBacteria BAA35294 http://www.ensemblgenomes.org/id/BAA35294 EnsemblBacteria BAA35294 http://www.ensemblgenomes.org/id/BAA35294 EnsemblBacteria BAA35294 http://www.ensemblgenomes.org/id/BAA35294 EnsemblBacteria b0647 http://www.ensemblgenomes.org/id/b0647 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 1.25.40.10 http://www.cathdb.info/version/latest/superfamily/1.25.40.10 GeneID 945243 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945243 HOGENOM HOG000009370 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009370&db=HOGENOM6 InParanoid P77296 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77296 InterPro IPR006597 http://www.ebi.ac.uk/interpro/entry/IPR006597 InterPro IPR011990 http://www.ebi.ac.uk/interpro/entry/IPR011990 KEGG_Gene ecj:JW0642 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0642 KEGG_Gene eco:b0647 http://www.genome.jp/dbget-bin/www_bget?eco:b0647 KEGG_Orthology KO:K07126 http://www.genome.jp/dbget-bin/www_bget?KO:K07126 OMA AMANYAF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AMANYAF PSORT swissprot:YBET_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBET_ECOLI PSORT-B swissprot:YBET_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBET_ECOLI PSORT2 swissprot:YBET_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBET_ECOLI Pfam PF08238 http://pfam.xfam.org/family/PF08238 Phobius swissprot:YBET_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBET_ECOLI PhylomeDB P77296 http://phylomedb.org/?seqid=P77296 ProteinModelPortal P77296 http://www.proteinmodelportal.org/query/uniprot/P77296 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 25534751 http://www.ncbi.nlm.nih.gov/pubmed/25534751 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415180 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415180 RefSeq WP_001035674 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001035674 SMART SM00671 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00671 SMR P77296 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77296 STRING 511145.b0647 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0647&targetmode=cogs STRING COG0790 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0790&targetmode=cogs UniProtKB YBET_ECOLI http://www.uniprot.org/uniprot/YBET_ECOLI UniProtKB-AC P77296 http://www.uniprot.org/uniprot/P77296 charge swissprot:YBET_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBET_ECOLI eggNOG COG0790 http://eggnogapi.embl.de/nog_data/html/tree/COG0790 eggNOG ENOG4107JFD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107JFD epestfind swissprot:YBET_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBET_ECOLI garnier swissprot:YBET_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBET_ECOLI helixturnhelix swissprot:YBET_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBET_ECOLI hmoment swissprot:YBET_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBET_ECOLI iep swissprot:YBET_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBET_ECOLI inforesidue swissprot:YBET_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBET_ECOLI octanol swissprot:YBET_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBET_ECOLI pepcoil swissprot:YBET_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBET_ECOLI pepdigest swissprot:YBET_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBET_ECOLI pepinfo swissprot:YBET_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBET_ECOLI pepnet swissprot:YBET_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBET_ECOLI pepstats swissprot:YBET_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBET_ECOLI pepwheel swissprot:YBET_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBET_ECOLI pepwindow swissprot:YBET_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBET_ECOLI sigcleave swissprot:YBET_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBET_ECOLI ## Database ID URL or Descriptions # AltName Deoxyinosine 3'endonuclease {ECO:0000255|HAMAP-Rule MF_00801} # AltName Deoxyribonuclease V {ECO:0000255|HAMAP-Rule MF_00801} # BIOPHYSICOCHEMICAL PROPERTIES NFI_ECOLI pH dependence Optimum pH is 7.0-7.5. {ECO 0000269|PubMed 8206931, ECO 0000269|PubMed 9388217}; # BioGrid 4263468 105 # CATALYTIC ACTIVITY NFI_ECOLI Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate. {ECO 0000255|HAMAP-Rule MF_00801, ECO 0000269|PubMed 6246346, ECO 0000269|PubMed 8206931, ECO 0000269|PubMed 9388217}. # CDD cd06559 Endonuclease_V # COFACTOR NFI_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_00801, ECO 0000269|PubMed 8206931, ECO 0000269|PubMed 9388217}; # EcoGene EG11915 nfi # FUNCTION NFI_ECOLI DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Has a wide substrate spectrum. In addition to deoxyinosine-containing DNA, the enzyme cleaves DNA containing urea residues, AP sites, base mismatches, insertion/deletion mismatches, flaps, and pseudo-Y structures. Participates in the excision repair of hypoxanthine and xanthine (deaminated adenine and guanine) in DNA. It thereby reduces the mutagenic effects of nitrous acid by attacking lesions caused by nitrosative deamination. Also active on inosines in single- and double-stranded RNA. May cleave tRNA(Arg2), which contains inosine at the wobble position. {ECO 0000255|HAMAP-Rule MF_00801, ECO 0000269|PubMed 11104906, ECO 0000269|PubMed 23912683, ECO 0000269|PubMed 6246346, ECO 0000269|PubMed 8206931, ECO 0000269|PubMed 9388217}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0043737 deoxyribonuclease V activity; IDA:EcoCyc. # GO_process GO:0006281 DNA repair; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0004518 nuclease activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # HAMAP MF_00801 Endonuclease_5 # IntAct P68739 30 # InterPro IPR007581 Endonuclease-V # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # Organism NFI_ECOLI Escherichia coli (strain K12) # PATRIC 32123519 VBIEscCol129921_4112 # PDB 4XPU X-ray; 2.40 A; A/B=1-214 # PIR A65207 A65207 # Pfam PF04493 Endonuclease_5 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Endonuclease V {ECO:0000255|HAMAP-Rule MF_00801} # RefSeq NP_418426 NC_000913.3 # RefSeq WP_000362388 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAC43096.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the endonuclease V family. {ECO:0000255|HAMAP-Rule MF_00801}. # SUBCELLULAR LOCATION NFI_ECOLI Cytoplasm. # SUBUNIT Monomer. {ECO:0000269|PubMed 8206931}. # eggNOG COG1515 LUCA # eggNOG ENOG4105Y7X Bacteria BLAST swissprot:NFI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NFI_ECOLI BioCyc ECOL316407:JW5547-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5547-MONOMER BioCyc EcoCyc:EG11915-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11915-MONOMER BioCyc MetaCyc:EG11915-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11915-MONOMER COG COG1515 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1515 DIP DIP-47986N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47986N DOI 10.1016/S0921-8777(00)00062-8 http://dx.doi.org/10.1016/S0921-8777(00)00062-8 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/ncomms3271 http://dx.doi.org/10.1038/ncomms3271 DOI 10.1074/jbc.272.49.30774 http://dx.doi.org/10.1074/jbc.272.49.30774 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.21.7 {ECO:0000255|HAMAP-Rule:MF_00801} http://www.genome.jp/dbget-bin/www_bget?EC:3.1.21.7 {ECO:0000255|HAMAP-Rule:MF_00801} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.21.7 {ECO:0000255|HAMAP-Rule:MF_00801} http://enzyme.expasy.org/EC/3.1.21.7 {ECO:0000255|HAMAP-Rule:MF_00801} EchoBASE EB1859 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1859 EcoGene EG11915 http://www.ecogene.org/geneInfo.php?eg_id=EG11915 EnsemblBacteria AAC76972 http://www.ensemblgenomes.org/id/AAC76972 EnsemblBacteria AAC76972 http://www.ensemblgenomes.org/id/AAC76972 EnsemblBacteria BAE77321 http://www.ensemblgenomes.org/id/BAE77321 EnsemblBacteria BAE77321 http://www.ensemblgenomes.org/id/BAE77321 EnsemblBacteria BAE77321 http://www.ensemblgenomes.org/id/BAE77321 EnsemblBacteria b3998 http://www.ensemblgenomes.org/id/b3998 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0043737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043737 GO_process GO:0006281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006281 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 948502 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948502 HAMAP MF_00801 http://hamap.expasy.org/unirule/MF_00801 HOGENOM HOG000229135 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000229135&db=HOGENOM6 InParanoid P68739 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P68739 IntAct P68739 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P68739* IntEnz 3.1.21.7 {ECO:0000255|HAMAP-Rule:MF_00801} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.21.7 {ECO:0000255|HAMAP-Rule:MF_00801} InterPro IPR007581 http://www.ebi.ac.uk/interpro/entry/IPR007581 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW5547 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5547 KEGG_Gene eco:b3998 http://www.genome.jp/dbget-bin/www_bget?eco:b3998 KEGG_Orthology KO:K05982 http://www.genome.jp/dbget-bin/www_bget?KO:K05982 MINT MINT-1226598 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1226598 OMA REYPALM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=REYPALM PDB 4XPU http://www.ebi.ac.uk/pdbe-srv/view/entry/4XPU PDBsum 4XPU http://www.ebi.ac.uk/pdbsum/4XPU PSORT swissprot:NFI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NFI_ECOLI PSORT-B swissprot:NFI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NFI_ECOLI PSORT2 swissprot:NFI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NFI_ECOLI Pfam PF04493 http://pfam.xfam.org/family/PF04493 Phobius swissprot:NFI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NFI_ECOLI PhylomeDB P68739 http://phylomedb.org/?seqid=P68739 ProteinModelPortal P68739 http://www.proteinmodelportal.org/query/uniprot/P68739 PubMed 11104906 http://www.ncbi.nlm.nih.gov/pubmed/11104906 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 23912683 http://www.ncbi.nlm.nih.gov/pubmed/23912683 PubMed 6246346 http://www.ncbi.nlm.nih.gov/pubmed/6246346 PubMed 8206931 http://www.ncbi.nlm.nih.gov/pubmed/8206931 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 8990280 http://www.ncbi.nlm.nih.gov/pubmed/8990280 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9388217 http://www.ncbi.nlm.nih.gov/pubmed/9388217 RefSeq NP_418426 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418426 RefSeq WP_000362388 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000362388 SMR P68739 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P68739 STRING 511145.b3998 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3998&targetmode=cogs STRING COG1515 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1515&targetmode=cogs UniProtKB NFI_ECOLI http://www.uniprot.org/uniprot/NFI_ECOLI UniProtKB-AC P68739 http://www.uniprot.org/uniprot/P68739 charge swissprot:NFI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NFI_ECOLI eggNOG COG1515 http://eggnogapi.embl.de/nog_data/html/tree/COG1515 eggNOG ENOG4105Y7X http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105Y7X epestfind swissprot:NFI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NFI_ECOLI garnier swissprot:NFI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NFI_ECOLI helixturnhelix swissprot:NFI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NFI_ECOLI hmoment swissprot:NFI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NFI_ECOLI iep swissprot:NFI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NFI_ECOLI inforesidue swissprot:NFI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NFI_ECOLI octanol swissprot:NFI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NFI_ECOLI pepcoil swissprot:NFI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NFI_ECOLI pepdigest swissprot:NFI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NFI_ECOLI pepinfo swissprot:NFI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NFI_ECOLI pepnet swissprot:NFI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NFI_ECOLI pepstats swissprot:NFI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NFI_ECOLI pepwheel swissprot:NFI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NFI_ECOLI pepwindow swissprot:NFI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NFI_ECOLI sigcleave swissprot:NFI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NFI_ECOLI ## Database ID URL or Descriptions # AltName TYRB_ECOLI Beta-methylphenylalanine transaminase # BioGrid 4262667 7 # CATALYTIC ACTIVITY (2S,3S)-3-methylphenylalanine + 2-oxoglutarate = (3S)-2-oxo-3-phenylbutanoate + L-glutamate. {ECO:0000269|PubMed 19731276}. # CATALYTIC ACTIVITY An aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate. {ECO:0000269|PubMed 19731276}. # COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI 597326; # EcoGene EG11040 tyrB # FUNCTION TYRB_ECOLI Broad-specificity enzyme that catalyzes the transamination of 2-ketoisocaproate, p-hydroxyphenylpyruvate, and phenylpyruvate to yield leucine, tyrosine, and phenylalanine, respectively. In vitro, is able to catalyze the conversion of beta-methyl phenylpyruvate to the nonproteinogenic amino acid (2S,3S)-beta-methyl-phenylalanine, a building block of the antibiotic mannopeptimycin produced by Streptomyces hygroscopicus NRRL3085. {ECO 0000269|PubMed 19731276}. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0030170 pyridoxal phosphate binding; IDA:EcoliWiki. # GO_function GO:0042802 identical protein binding; IBA:GO_Central. # GO_function TYRB_ECOLI GO 0004838 L-tyrosine 2-oxoglutarate aminotransferase activity; IDA EcoCyc. # GO_function TYRB_ECOLI GO 0008793 aromatic-amino-acid 2-oxoglutarate aminotransferase activity; IDA EcoCyc. # GO_function TYRB_ECOLI GO 0050048 L-leucine 2-oxoglutarate aminotransferase activity; IMP EcoCyc. # GO_function TYRB_ECOLI GO 0080130 L-phenylalanine 2-oxoglutarate aminotransferase activity; IEA UniProtKB-EC. # GO_process GO:0006532 aspartate biosynthetic process; IGI:EcoliWiki. # GO_process GO:0009098 leucine biosynthetic process; IMP:EcoCyc. # GO_process GO:0019292 tyrosine biosynthetic process from chorismate via 4-hydroxyphenylpyruvate; IDA:EcoCyc. # GO_process GO:0033585 L-phenylalanine biosynthetic process from chorismate via phenylpyruvate; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.640.10 -; 1. # IntAct P04693 2 # InterPro IPR000796 Asp_trans # InterPro IPR004838 NHTrfase_class1_PyrdxlP-BS # InterPro IPR004839 Aminotransferase_I/II # InterPro IPR015421 PyrdxlP-dep_Trfase_major_sub1 # InterPro IPR015424 PyrdxlP-dep_Trfase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01007 Amino acid related enzymes # KEGG_Pathway ko00270 Cysteine and methionine metabolism # KEGG_Pathway ko00350 Tyrosine metabolism # KEGG_Pathway ko00360 Phenylalanine metabolism # KEGG_Pathway ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis # KEGG_Pathway ko00401 Novobiocin biosynthesis # KEGG_Pathway ko00950 Isoquinoline alkaloid biosynthesis # KEGG_Pathway ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis # Organism TYRB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11879 PTHR11879 # PATHWAY Amino-acid biosynthesis; L-phenylalanine biosynthesis; L- phenylalanine from phenylpyruvate (ArAT route) step 1/1. # PATHWAY Amino-acid biosynthesis; L-tyrosine biosynthesis; L- tyrosine from (4-hydroxyphenyl)pyruvate step 1/1. # PATRIC 32123649 VBIEscCol129921_4173 # PDB 3FSL X-ray; 2.35 A; A/B/C/D/E/F=1-397 # PDB 3TAT X-ray; 3.50 A; A/B/C/D/E/F=1-397 # PIR A30379 XNECY # PRINTS PR00799 TRANSAMINASE # PROSITE PS00105 AA_TRANSFER_CLASS_1 # Pfam PF00155 Aminotran_1_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TYRB_ECOLI Aromatic-amino-acid aminotransferase # RefSeq NP_418478 NC_000913.3 # RefSeq WP_000486985 NZ_LN832404.1 # SIMILARITY Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. {ECO 0000305}. # SUBCELLULAR LOCATION TYRB_ECOLI Cytoplasm. # SUBUNIT TYRB_ECOLI Homodimer. # SUPFAM SSF53383 SSF53383 # UniPathway UPA00121 UER00347 # UniPathway UPA00122 UER00350 # eggNOG COG1448 LUCA # eggNOG ENOG4105CGF Bacteria BLAST swissprot:TYRB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TYRB_ECOLI BioCyc ECOL316407:JW4014-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4014-MONOMER BioCyc EcoCyc:TYRB-MONOMER http://biocyc.org/getid?id=EcoCyc:TYRB-MONOMER BioCyc MetaCyc:TYRB-MONOMER http://biocyc.org/getid?id=MetaCyc:TYRB-MONOMER COG COG1448 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1448 DOI 10.1002/cbic.200900351 http://dx.doi.org/10.1002/cbic.200900351 DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0006-291X(85)91851-0 http://dx.doi.org/10.1016/0006-291X(85)91851-0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2340593 http://dx.doi.org/10.1042/bj2340593 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1107/S0907444999006630 http://dx.doi.org/10.1107/S0907444999006630 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.6.1.107 http://www.genome.jp/dbget-bin/www_bget?EC:2.6.1.107 EC_number EC:2.6.1.57 http://www.genome.jp/dbget-bin/www_bget?EC:2.6.1.57 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M12047 http://www.ebi.ac.uk/ena/data/view/M12047 EMBL M17809 http://www.ebi.ac.uk/ena/data/view/M17809 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X03628 http://www.ebi.ac.uk/ena/data/view/X03628 ENZYME 2.6.1.107 http://enzyme.expasy.org/EC/2.6.1.107 ENZYME 2.6.1.57 http://enzyme.expasy.org/EC/2.6.1.57 EchoBASE EB1033 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1033 EcoGene EG11040 http://www.ecogene.org/geneInfo.php?eg_id=EG11040 EnsemblBacteria AAC77024 http://www.ensemblgenomes.org/id/AAC77024 EnsemblBacteria AAC77024 http://www.ensemblgenomes.org/id/AAC77024 EnsemblBacteria BAE78056 http://www.ensemblgenomes.org/id/BAE78056 EnsemblBacteria BAE78056 http://www.ensemblgenomes.org/id/BAE78056 EnsemblBacteria BAE78056 http://www.ensemblgenomes.org/id/BAE78056 EnsemblBacteria b4054 http://www.ensemblgenomes.org/id/b4054 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004838 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004838 GO_function GO:0008793 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008793 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0050048 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050048 GO_function GO:0080130 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0080130 GO_process GO:0006532 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006532 GO_process GO:0009098 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009098 GO_process GO:0019292 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019292 GO_process GO:0033585 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033585 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.640.10 http://www.cathdb.info/version/latest/superfamily/3.40.640.10 GeneID 948563 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948563 HOGENOM HOG000185899 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000185899&db=HOGENOM6 InParanoid P04693 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P04693 IntAct P04693 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P04693* IntEnz 2.6.1.107 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.6.1.107 IntEnz 2.6.1.57 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.6.1.57 InterPro IPR000796 http://www.ebi.ac.uk/interpro/entry/IPR000796 InterPro IPR004838 http://www.ebi.ac.uk/interpro/entry/IPR004838 InterPro IPR004839 http://www.ebi.ac.uk/interpro/entry/IPR004839 InterPro IPR015421 http://www.ebi.ac.uk/interpro/entry/IPR015421 InterPro IPR015424 http://www.ebi.ac.uk/interpro/entry/IPR015424 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Gene ecj:JW4014 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4014 KEGG_Gene eco:b4054 http://www.genome.jp/dbget-bin/www_bget?eco:b4054 KEGG_Orthology KO:K00832 http://www.genome.jp/dbget-bin/www_bget?KO:K00832 KEGG_Pathway ko00270 http://www.genome.jp/kegg-bin/show_pathway?ko00270 KEGG_Pathway ko00350 http://www.genome.jp/kegg-bin/show_pathway?ko00350 KEGG_Pathway ko00360 http://www.genome.jp/kegg-bin/show_pathway?ko00360 KEGG_Pathway ko00400 http://www.genome.jp/kegg-bin/show_pathway?ko00400 KEGG_Pathway ko00401 http://www.genome.jp/kegg-bin/show_pathway?ko00401 KEGG_Pathway ko00950 http://www.genome.jp/kegg-bin/show_pathway?ko00950 KEGG_Pathway ko00960 http://www.genome.jp/kegg-bin/show_pathway?ko00960 KEGG_Reaction rn:R00694 http://www.genome.jp/dbget-bin/www_bget?rn:R00694 KEGG_Reaction rn:R00734 http://www.genome.jp/dbget-bin/www_bget?rn:R00734 KEGG_Reaction rn:R01731 http://www.genome.jp/dbget-bin/www_bget?rn:R01731 KEGG_Reaction rn:R07396 http://www.genome.jp/dbget-bin/www_bget?rn:R07396 OMA METFKQD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=METFKQD PANTHER PTHR11879 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11879 PDB 3FSL http://www.ebi.ac.uk/pdbe-srv/view/entry/3FSL PDB 3TAT http://www.ebi.ac.uk/pdbe-srv/view/entry/3TAT PDBsum 3FSL http://www.ebi.ac.uk/pdbsum/3FSL PDBsum 3TAT http://www.ebi.ac.uk/pdbsum/3TAT PRINTS PR00799 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00799 PROSITE PS00105 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00105 PSORT swissprot:TYRB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TYRB_ECOLI PSORT-B swissprot:TYRB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TYRB_ECOLI PSORT2 swissprot:TYRB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TYRB_ECOLI Pfam PF00155 http://pfam.xfam.org/family/PF00155 Phobius swissprot:TYRB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TYRB_ECOLI PhylomeDB P04693 http://phylomedb.org/?seqid=P04693 ProteinModelPortal P04693 http://www.proteinmodelportal.org/query/uniprot/P04693 PubMed 10417420 http://www.ncbi.nlm.nih.gov/pubmed/10417420 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19731276 http://www.ncbi.nlm.nih.gov/pubmed/19731276 PubMed 3308851 http://www.ncbi.nlm.nih.gov/pubmed/3308851 PubMed 3521591 http://www.ncbi.nlm.nih.gov/pubmed/3521591 PubMed 3907634 http://www.ncbi.nlm.nih.gov/pubmed/3907634 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_418478 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418478 RefSeq WP_000486985 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000486985 SMR P04693 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P04693 STRING 511145.b4054 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4054&targetmode=cogs STRING COG1448 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1448&targetmode=cogs SUPFAM SSF53383 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53383 UniProtKB TYRB_ECOLI http://www.uniprot.org/uniprot/TYRB_ECOLI UniProtKB-AC P04693 http://www.uniprot.org/uniprot/P04693 charge swissprot:TYRB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TYRB_ECOLI eggNOG COG1448 http://eggnogapi.embl.de/nog_data/html/tree/COG1448 eggNOG ENOG4105CGF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CGF epestfind swissprot:TYRB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TYRB_ECOLI garnier swissprot:TYRB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TYRB_ECOLI helixturnhelix swissprot:TYRB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TYRB_ECOLI hmoment swissprot:TYRB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TYRB_ECOLI iep swissprot:TYRB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TYRB_ECOLI inforesidue swissprot:TYRB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TYRB_ECOLI octanol swissprot:TYRB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TYRB_ECOLI pepcoil swissprot:TYRB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TYRB_ECOLI pepdigest swissprot:TYRB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TYRB_ECOLI pepinfo swissprot:TYRB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TYRB_ECOLI pepnet swissprot:TYRB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TYRB_ECOLI pepstats swissprot:TYRB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TYRB_ECOLI pepwheel swissprot:TYRB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TYRB_ECOLI pepwindow swissprot:TYRB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TYRB_ECOLI sigcleave swissprot:TYRB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TYRB_ECOLI ## Database ID URL or Descriptions # BioGrid 4261772 18 # EcoGene EG14095 yfbK # Gene3D 3.40.50.410 -; 1. # IntAct P76481 2 # InterPro IPR002035 VWF_A # InterPro IPR021908 DUF3520 # InterPro IPR022156 Uncharacterised_YfbK_N # Organism YFBK_ECOLI Escherichia coli (strain K12) # PATRIC 32119907 VBIEscCol129921_2363 # PIR D64998 D64998 # PROSITE PS50234 VWFA # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF00092 VWA # Pfam PF12034 DUF3520 # Pfam PF12450 vWF_A # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFBK_ECOLI Uncharacterized protein YfbK # RefSeq NP_416773 NC_000913.3 # RefSeq WP_001244806 NZ_LN832404.1 # SIMILARITY Contains 1 VWFA domain. {ECO:0000255|PROSITE- ProRule PRU00219}. # SIMILARITY To Synechocystis PCC 6803 sll0103. {ECO 0000305}. # SMART SM00327 VWA # SUPFAM SSF53300 SSF53300 # TCDB 1.A.13.2 the epithelial chloride channel (e-clc) family # eggNOG COG2304 LUCA # eggNOG ENOG4105CP2 Bacteria BLAST swissprot:YFBK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFBK_ECOLI BioCyc ECOL316407:JW2265-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2265-MONOMER BioCyc EcoCyc:G7177-MONOMER http://biocyc.org/getid?id=EcoCyc:G7177-MONOMER COG COG2304 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2304 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3848 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3848 EcoGene EG14095 http://www.ecogene.org/geneInfo.php?eg_id=EG14095 EnsemblBacteria AAC75330 http://www.ensemblgenomes.org/id/AAC75330 EnsemblBacteria AAC75330 http://www.ensemblgenomes.org/id/AAC75330 EnsemblBacteria BAE76678 http://www.ensemblgenomes.org/id/BAE76678 EnsemblBacteria BAE76678 http://www.ensemblgenomes.org/id/BAE76678 EnsemblBacteria BAE76678 http://www.ensemblgenomes.org/id/BAE76678 EnsemblBacteria b2270 http://www.ensemblgenomes.org/id/b2270 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.40.50.410 http://www.cathdb.info/version/latest/superfamily/3.40.50.410 GeneID 946743 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946743 HOGENOM HOG000295651 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000295651&db=HOGENOM6 InParanoid P76481 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76481 IntAct P76481 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76481* InterPro IPR002035 http://www.ebi.ac.uk/interpro/entry/IPR002035 InterPro IPR021908 http://www.ebi.ac.uk/interpro/entry/IPR021908 InterPro IPR022156 http://www.ebi.ac.uk/interpro/entry/IPR022156 KEGG_Gene ecj:JW2265 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2265 KEGG_Gene eco:b2270 http://www.genome.jp/dbget-bin/www_bget?eco:b2270 KEGG_Orthology KO:K07114 http://www.genome.jp/dbget-bin/www_bget?KO:K07114 OMA AREDFNN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AREDFNN PROSITE PS50234 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50234 PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YFBK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFBK_ECOLI PSORT-B swissprot:YFBK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFBK_ECOLI PSORT2 swissprot:YFBK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFBK_ECOLI Pfam PF00092 http://pfam.xfam.org/family/PF00092 Pfam PF12034 http://pfam.xfam.org/family/PF12034 Pfam PF12450 http://pfam.xfam.org/family/PF12450 Phobius swissprot:YFBK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFBK_ECOLI PhylomeDB P76481 http://phylomedb.org/?seqid=P76481 ProteinModelPortal P76481 http://www.proteinmodelportal.org/query/uniprot/P76481 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416773 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416773 RefSeq WP_001244806 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001244806 SMART SM00327 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00327 SMR P76481 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76481 STRING 511145.b2270 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2270&targetmode=cogs STRING COG2304 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2304&targetmode=cogs SUPFAM SSF53300 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53300 TCDB 1.A.13.2 http://www.tcdb.org/search/result.php?tc=1.A.13.2 UniProtKB YFBK_ECOLI http://www.uniprot.org/uniprot/YFBK_ECOLI UniProtKB-AC P76481 http://www.uniprot.org/uniprot/P76481 charge swissprot:YFBK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFBK_ECOLI eggNOG COG2304 http://eggnogapi.embl.de/nog_data/html/tree/COG2304 eggNOG ENOG4105CP2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CP2 epestfind swissprot:YFBK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFBK_ECOLI garnier swissprot:YFBK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFBK_ECOLI helixturnhelix swissprot:YFBK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFBK_ECOLI hmoment swissprot:YFBK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFBK_ECOLI iep swissprot:YFBK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFBK_ECOLI inforesidue swissprot:YFBK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFBK_ECOLI octanol swissprot:YFBK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFBK_ECOLI pepcoil swissprot:YFBK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFBK_ECOLI pepdigest swissprot:YFBK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFBK_ECOLI pepinfo swissprot:YFBK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFBK_ECOLI pepnet swissprot:YFBK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFBK_ECOLI pepstats swissprot:YFBK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFBK_ECOLI pepwheel swissprot:YFBK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFBK_ECOLI pepwindow swissprot:YFBK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFBK_ECOLI sigcleave swissprot:YFBK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFBK_ECOLI ## Database ID URL or Descriptions # BioGrid 4262074 12 # CDD cd00865 PEBP_bact_arch # EcoGene EG13628 ybcL # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_process GO:0043086 negative regulation of catalytic activity; IEA:GOC. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0008150 biological_process # Gene3D 3.90.280.10 -; 1. # InterPro IPR005247 YbhB_YbcL # InterPro IPR008914 PEBP # MISCELLANEOUS YBCL_ECOLI Encoded by the cryptic lambdoid prophage DLP12. # Organism YBCL_ECOLI Escherichia coli (strain K12) # PDB 1FUX X-ray; 1.81 A; A/B=22-183 # PIR G64786 G64786 # Pfam PF01161 PBP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBCL_ECOLI UPF0098 protein YbcL # RefSeq NP_415077 NC_000913.3 # RefSeq WP_001306955 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0098 family. {ECO 0000305}. # SUBCELLULAR LOCATION YBCL_ECOLI Periplasm {ECO 0000269|PubMed 11439028}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 11439028}. # SUPFAM SSF49777 SSF49777 # TIGRFAMs TIGR00481 TIGR00481 # eggNOG COG1881 LUCA # eggNOG ENOG4108V1U Bacteria BLAST swissprot:YBCL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBCL_ECOLI BioCyc ECOL316407:JW0533-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0533-MONOMER BioCyc EcoCyc:G6301-MONOMER http://biocyc.org/getid?id=EcoCyc:G6301-MONOMER COG COG1881 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1881 DOI 10.1006/jmbi.2001.4784 http://dx.doi.org/10.1006/jmbi.2001.4784 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB3393 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3393 EcoGene EG13628 http://www.ecogene.org/geneInfo.php?eg_id=EG13628 EnsemblBacteria AAC73646 http://www.ensemblgenomes.org/id/AAC73646 EnsemblBacteria AAC73646 http://www.ensemblgenomes.org/id/AAC73646 EnsemblBacteria BAE76320 http://www.ensemblgenomes.org/id/BAE76320 EnsemblBacteria BAE76320 http://www.ensemblgenomes.org/id/BAE76320 EnsemblBacteria BAE76320 http://www.ensemblgenomes.org/id/BAE76320 EnsemblBacteria b0545 http://www.ensemblgenomes.org/id/b0545 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_process GO:0043086 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043086 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.90.280.10 http://www.cathdb.info/version/latest/superfamily/3.90.280.10 GeneID 945165 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945165 HOGENOM HOG000236247 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000236247&db=HOGENOM6 InParanoid P77368 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77368 InterPro IPR005247 http://www.ebi.ac.uk/interpro/entry/IPR005247 InterPro IPR008914 http://www.ebi.ac.uk/interpro/entry/IPR008914 KEGG_Gene ecj:JW0533 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0533 KEGG_Gene eco:b0545 http://www.genome.jp/dbget-bin/www_bget?eco:b0545 KEGG_Orthology KO:K06910 http://www.genome.jp/dbget-bin/www_bget?KO:K06910 OMA QEGHPMA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QEGHPMA PDB 1FUX http://www.ebi.ac.uk/pdbe-srv/view/entry/1FUX PDBsum 1FUX http://www.ebi.ac.uk/pdbsum/1FUX PSORT swissprot:YBCL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBCL_ECOLI PSORT-B swissprot:YBCL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBCL_ECOLI PSORT2 swissprot:YBCL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBCL_ECOLI Pfam PF01161 http://pfam.xfam.org/family/PF01161 Phobius swissprot:YBCL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBCL_ECOLI PhylomeDB P77368 http://phylomedb.org/?seqid=P77368 ProteinModelPortal P77368 http://www.proteinmodelportal.org/query/uniprot/P77368 PubMed 11439028 http://www.ncbi.nlm.nih.gov/pubmed/11439028 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415077 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415077 RefSeq WP_001306955 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001306955 SMR P77368 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77368 STRING 511145.b0545 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0545&targetmode=cogs STRING COG1881 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1881&targetmode=cogs SUPFAM SSF49777 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49777 TIGRFAMs TIGR00481 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00481 UniProtKB YBCL_ECOLI http://www.uniprot.org/uniprot/YBCL_ECOLI UniProtKB-AC P77368 http://www.uniprot.org/uniprot/P77368 charge swissprot:YBCL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBCL_ECOLI eggNOG COG1881 http://eggnogapi.embl.de/nog_data/html/tree/COG1881 eggNOG ENOG4108V1U http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108V1U epestfind swissprot:YBCL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBCL_ECOLI garnier swissprot:YBCL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBCL_ECOLI helixturnhelix swissprot:YBCL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBCL_ECOLI hmoment swissprot:YBCL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBCL_ECOLI iep swissprot:YBCL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBCL_ECOLI inforesidue swissprot:YBCL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBCL_ECOLI octanol swissprot:YBCL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBCL_ECOLI pepcoil swissprot:YBCL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBCL_ECOLI pepdigest swissprot:YBCL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBCL_ECOLI pepinfo swissprot:YBCL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBCL_ECOLI pepnet swissprot:YBCL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBCL_ECOLI pepstats swissprot:YBCL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBCL_ECOLI pepwheel swissprot:YBCL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBCL_ECOLI pepwindow swissprot:YBCL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBCL_ECOLI sigcleave swissprot:YBCL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBCL_ECOLI ## Database ID URL or Descriptions # BioGrid 4261322 211 # EcoGene EG14204 yfgH # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR008816 Gly_zipper_2TM_dom # Organism YFGH_ECOLI Escherichia coli (strain K12) # PATRIC 32120401 VBIEscCol129921_2603 # PIR H65026 H65026 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF05433 Rick_17kDa_Anti # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFGH_ECOLI Uncharacterized lipoprotein YfgH # RefSeq NP_417000 NC_000913.3 # SUBCELLULAR LOCATION YFGH_ECOLI Cell membrane {ECO 0000255|PROSITE- ProRule PRU00303}; Lipid-anchor {ECO 0000255|PROSITE- ProRule PRU00303}. # eggNOG ENOG4108ZMA Bacteria # eggNOG ENOG4111SPV LUCA BLAST swissprot:YFGH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFGH_ECOLI BioCyc ECOL316407:JW5400-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5400-MONOMER BioCyc EcoCyc:G7316-MONOMER http://biocyc.org/getid?id=EcoCyc:G7316-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3956 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3956 EcoGene EG14204 http://www.ecogene.org/geneInfo.php?eg_id=EG14204 EnsemblBacteria AAC75558 http://www.ensemblgenomes.org/id/AAC75558 EnsemblBacteria AAC75558 http://www.ensemblgenomes.org/id/AAC75558 EnsemblBacteria BAE76726 http://www.ensemblgenomes.org/id/BAE76726 EnsemblBacteria BAE76726 http://www.ensemblgenomes.org/id/BAE76726 EnsemblBacteria BAE76726 http://www.ensemblgenomes.org/id/BAE76726 EnsemblBacteria b2505 http://www.ensemblgenomes.org/id/b2505 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 945709 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945709 HOGENOM HOG000123063 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000123063&db=HOGENOM6 InterPro IPR008816 http://www.ebi.ac.uk/interpro/entry/IPR008816 KEGG_Gene ecj:JW5400 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5400 KEGG_Gene eco:b2505 http://www.genome.jp/dbget-bin/www_bget?eco:b2505 OMA ETRTVNI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ETRTVNI PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YFGH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFGH_ECOLI PSORT-B swissprot:YFGH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFGH_ECOLI PSORT2 swissprot:YFGH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFGH_ECOLI Pfam PF05433 http://pfam.xfam.org/family/PF05433 Phobius swissprot:YFGH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFGH_ECOLI ProteinModelPortal P65290 http://www.proteinmodelportal.org/query/uniprot/P65290 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417000 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417000 STRING 511145.b2505 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2505&targetmode=cogs UniProtKB YFGH_ECOLI http://www.uniprot.org/uniprot/YFGH_ECOLI UniProtKB-AC P65290 http://www.uniprot.org/uniprot/P65290 charge swissprot:YFGH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFGH_ECOLI eggNOG ENOG4108ZMA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZMA eggNOG ENOG4111SPV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111SPV epestfind swissprot:YFGH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFGH_ECOLI garnier swissprot:YFGH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFGH_ECOLI helixturnhelix swissprot:YFGH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFGH_ECOLI hmoment swissprot:YFGH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFGH_ECOLI iep swissprot:YFGH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFGH_ECOLI inforesidue swissprot:YFGH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFGH_ECOLI octanol swissprot:YFGH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFGH_ECOLI pepcoil swissprot:YFGH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFGH_ECOLI pepdigest swissprot:YFGH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFGH_ECOLI pepinfo swissprot:YFGH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFGH_ECOLI pepnet swissprot:YFGH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFGH_ECOLI pepstats swissprot:YFGH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFGH_ECOLI pepwheel swissprot:YFGH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFGH_ECOLI pepwindow swissprot:YFGH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFGH_ECOLI sigcleave swissprot:YFGH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFGH_ECOLI ## Database ID URL or Descriptions # BioGrid 4261118 154 # EcoGene EG11047 ugpB # FUNCTION UGPB_ECOLI sn-glycerol-3-phosphate and glycerophosphoryl diester- binding protein interacts with the binding protein-dependent transport system UgpACE. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0005215 transporter activity; IEA:InterPro. # GO_process GO:0001407 glycerophosphodiester transport; IDA:EcoCyc. # GO_process GO:0015794 glycerol-3-phosphate transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006810 transport # IntAct P0AG80 15 # InterPro IPR006061 SBP_1_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00198 Putative sn-glycerol-phosphate transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism UGPB_ECOLI Escherichia coli (strain K12) # PATRIC 32122346 VBIEscCol129921_3550 # PDB 4AQ4 X-ray; 1.80 A; A=24-438 # PIR S47672 JGECGP # PROSITE PS01037 SBP_BACTERIAL_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UGPB_ECOLI sn-glycerol-3-phosphate-binding periplasmic protein UgpB # RefSeq NP_417910 NC_000913.3 # RefSeq WP_000803190 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial solute-binding protein 1 family. {ECO 0000305}. # SUBCELLULAR LOCATION UGPB_ECOLI Periplasm. # SUBUNIT The complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute- binding protein (UgpB). {ECO 0000305}. # TCDB 3.A.1.1 the atp-binding cassette (abc) superfamily # eggNOG COG1653 LUCA # eggNOG ENOG4105BZ7 Bacteria BLAST swissprot:UGPB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UGPB_ECOLI BioCyc ECOL316407:JW3418-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3418-MONOMER BioCyc EcoCyc:UGPB-MONOMER http://biocyc.org/getid?id=EcoCyc:UGPB-MONOMER BioCyc MetaCyc:UGPB-MONOMER http://biocyc.org/getid?id=MetaCyc:UGPB-MONOMER COG COG1653 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1653 DIP DIP-35942N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35942N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1111/j.1365-2958.1988.tb00088.x http://dx.doi.org/10.1111/j.1365-2958.1988.tb00088.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X13141 http://www.ebi.ac.uk/ena/data/view/X13141 EchoBASE EB1040 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1040 EcoGene EG11047 http://www.ecogene.org/geneInfo.php?eg_id=EG11047 EnsemblBacteria AAC76478 http://www.ensemblgenomes.org/id/AAC76478 EnsemblBacteria AAC76478 http://www.ensemblgenomes.org/id/AAC76478 EnsemblBacteria BAE77840 http://www.ensemblgenomes.org/id/BAE77840 EnsemblBacteria BAE77840 http://www.ensemblgenomes.org/id/BAE77840 EnsemblBacteria BAE77840 http://www.ensemblgenomes.org/id/BAE77840 EnsemblBacteria b3453 http://www.ensemblgenomes.org/id/b3453 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_process GO:0001407 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001407 GO_process GO:0015794 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015794 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 947962 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947962 HOGENOM HOG000255083 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000255083&db=HOGENOM6 InParanoid P0AG80 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AG80 IntAct P0AG80 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AG80* InterPro IPR006061 http://www.ebi.ac.uk/interpro/entry/IPR006061 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3418 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3418 KEGG_Gene eco:b3453 http://www.genome.jp/dbget-bin/www_bget?eco:b3453 KEGG_Orthology KO:K05813 http://www.genome.jp/dbget-bin/www_bget?KO:K05813 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 MINT MINT-1291422 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1291422 OMA ESFSAWH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ESFSAWH PDB 4AQ4 http://www.ebi.ac.uk/pdbe-srv/view/entry/4AQ4 PDBsum 4AQ4 http://www.ebi.ac.uk/pdbsum/4AQ4 PROSITE PS01037 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01037 PSORT swissprot:UGPB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UGPB_ECOLI PSORT-B swissprot:UGPB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UGPB_ECOLI PSORT2 swissprot:UGPB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UGPB_ECOLI Phobius swissprot:UGPB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UGPB_ECOLI PhylomeDB P0AG80 http://phylomedb.org/?seqid=P0AG80 ProteinModelPortal P0AG80 http://www.proteinmodelportal.org/query/uniprot/P0AG80 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3062310 http://www.ncbi.nlm.nih.gov/pubmed/3062310 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417910 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417910 RefSeq WP_000803190 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000803190 SMR P0AG80 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AG80 STRING 511145.b3453 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3453&targetmode=cogs STRING COG1653 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1653&targetmode=cogs TCDB 3.A.1.1 http://www.tcdb.org/search/result.php?tc=3.A.1.1 UniProtKB UGPB_ECOLI http://www.uniprot.org/uniprot/UGPB_ECOLI UniProtKB-AC P0AG80 http://www.uniprot.org/uniprot/P0AG80 charge swissprot:UGPB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UGPB_ECOLI eggNOG COG1653 http://eggnogapi.embl.de/nog_data/html/tree/COG1653 eggNOG ENOG4105BZ7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZ7 epestfind swissprot:UGPB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UGPB_ECOLI garnier swissprot:UGPB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UGPB_ECOLI helixturnhelix swissprot:UGPB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UGPB_ECOLI hmoment swissprot:UGPB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UGPB_ECOLI iep swissprot:UGPB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UGPB_ECOLI inforesidue swissprot:UGPB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UGPB_ECOLI octanol swissprot:UGPB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UGPB_ECOLI pepcoil swissprot:UGPB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UGPB_ECOLI pepdigest swissprot:UGPB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UGPB_ECOLI pepinfo swissprot:UGPB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UGPB_ECOLI pepnet swissprot:UGPB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UGPB_ECOLI pepstats swissprot:UGPB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UGPB_ECOLI pepwheel swissprot:UGPB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UGPB_ECOLI pepwindow swissprot:UGPB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UGPB_ECOLI sigcleave swissprot:UGPB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UGPB_ECOLI ## Database ID URL or Descriptions # BioGrid 4262813 4 # EcoGene EG13609 proY # FUNCTION PROY_ECOLI Permease that is involved in the transport across the cytoplasmic membrane of proline. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0015179 L-amino acid transmembrane transporter activity; IBA:GO_Central. # GO_function GO:0015297 antiporter activity; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # InterPro IPR002293 AA/rel_permease1 # InterPro IPR004840 Amoino_acid_permease_CS # InterPro IPR004841 AA-permease/SLC12A_dom # KEGG_Brite ko02000 Transporters # Organism PROY_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11785 PTHR11785 # PATRIC 32115953 VBIEscCol129921_0418 # PIR B64769 B64769 # PIRSF PIRSF006060 AA_transporter # PROSITE PS00218 AMINO_ACID_PERMEASE_1 # Pfam PF00324 AA_permease # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PROY_ECOLI Proline-specific permease ProY # RefSeq NP_414936 NC_000913.3 # RefSeq WP_001295329 NZ_LN832404.1 # SIMILARITY Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family. {ECO 0000305}. # SUBCELLULAR LOCATION PROY_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.3.1.23 the amino acid-polyamine-organocation (apc) family # eggNOG COG1113 LUCA # eggNOG ENOG4105C85 Bacteria BLAST swissprot:PROY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PROY_ECOLI BioCyc ECOL316407:JW5055-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5055-MONOMER BioCyc EcoCyc:PROY-MONOMER http://biocyc.org/getid?id=EcoCyc:PROY-MONOMER COG COG1113 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1113 DIP DIP-47977N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47977N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EchoBASE EB3376 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3376 EcoGene EG13609 http://www.ecogene.org/geneInfo.php?eg_id=EG13609 EnsemblBacteria AAC73505 http://www.ensemblgenomes.org/id/AAC73505 EnsemblBacteria AAC73505 http://www.ensemblgenomes.org/id/AAC73505 EnsemblBacteria BAE76182 http://www.ensemblgenomes.org/id/BAE76182 EnsemblBacteria BAE76182 http://www.ensemblgenomes.org/id/BAE76182 EnsemblBacteria BAE76182 http://www.ensemblgenomes.org/id/BAE76182 EnsemblBacteria b0402 http://www.ensemblgenomes.org/id/b0402 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015179 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015179 GO_function GO:0015297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015297 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GeneID 945050 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945050 HOGENOM HOG000261849 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261849&db=HOGENOM6 InParanoid P0AAE2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAE2 IntAct P0AAE2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAE2* InterPro IPR002293 http://www.ebi.ac.uk/interpro/entry/IPR002293 InterPro IPR004840 http://www.ebi.ac.uk/interpro/entry/IPR004840 InterPro IPR004841 http://www.ebi.ac.uk/interpro/entry/IPR004841 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5055 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5055 KEGG_Gene eco:b0402 http://www.genome.jp/dbget-bin/www_bget?eco:b0402 KEGG_Orthology KO:K11736 http://www.genome.jp/dbget-bin/www_bget?KO:K11736 MINT MINT-1317808 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1317808 OMA YHPETRI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YHPETRI PANTHER PTHR11785 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11785 PROSITE PS00218 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00218 PSORT swissprot:PROY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PROY_ECOLI PSORT-B swissprot:PROY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PROY_ECOLI PSORT2 swissprot:PROY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PROY_ECOLI Pfam PF00324 http://pfam.xfam.org/family/PF00324 Phobius swissprot:PROY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PROY_ECOLI PhylomeDB P0AAE2 http://phylomedb.org/?seqid=P0AAE2 ProteinModelPortal P0AAE2 http://www.proteinmodelportal.org/query/uniprot/P0AAE2 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414936 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414936 RefSeq WP_001295329 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295329 STRING 511145.b0402 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0402&targetmode=cogs STRING COG1113 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1113&targetmode=cogs TCDB 2.A.3.1.23 http://www.tcdb.org/search/result.php?tc=2.A.3.1.23 UniProtKB PROY_ECOLI http://www.uniprot.org/uniprot/PROY_ECOLI UniProtKB-AC P0AAE2 http://www.uniprot.org/uniprot/P0AAE2 charge swissprot:PROY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PROY_ECOLI eggNOG COG1113 http://eggnogapi.embl.de/nog_data/html/tree/COG1113 eggNOG ENOG4105C85 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C85 epestfind swissprot:PROY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PROY_ECOLI garnier swissprot:PROY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PROY_ECOLI helixturnhelix swissprot:PROY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PROY_ECOLI hmoment swissprot:PROY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PROY_ECOLI iep swissprot:PROY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PROY_ECOLI inforesidue swissprot:PROY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PROY_ECOLI octanol swissprot:PROY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PROY_ECOLI pepcoil swissprot:PROY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PROY_ECOLI pepdigest swissprot:PROY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PROY_ECOLI pepinfo swissprot:PROY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PROY_ECOLI pepnet swissprot:PROY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PROY_ECOLI pepstats swissprot:PROY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PROY_ECOLI pepwheel swissprot:PROY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PROY_ECOLI pepwindow swissprot:PROY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PROY_ECOLI sigcleave swissprot:PROY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PROY_ECOLI ## Database ID URL or Descriptions # AltName OTC2_ECOLI OTCase-2 # BIOPHYSICOCHEMICAL PROPERTIES OTC2_ECOLI Kinetic parameters KM=0.02 mM for carbamoyl phosphate {ECO 0000269|PubMed 789338}; KM=5 mM for L-ornithine {ECO 0000269|PubMed 789338}; # BioGrid 4261491 11 # CATALYTIC ACTIVITY OTC2_ECOLI Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. # EcoGene EG10067 argF # FUNCTION OTC2_ECOLI Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline, which is a substrate for argininosuccinate synthetase, the enzyme involved in the final step in arginine biosynthesis. {ECO 0000269|PubMed 789338}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0004585 ornithine carbamoyltransferase activity; IDA:EcoCyc. # GO_function GO:0016597 amino acid binding; IEA:InterPro. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0000050 urea cycle; IBA:GO_Central. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0042450 arginine biosynthetic process via ornithine; IBA:GO_Central. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0071941 nitrogen cycle metabolic process # Gene3D 3.40.50.1370 -; 2. # HAMAP MF_01109 OTCase # IntAct P06960 7 # InterPro IPR002292 Orn/put_carbamltrans # InterPro IPR006130 Asp/Orn_carbamoylTrfase # InterPro IPR006131 Asp_carbamoyltransf_Asp/Orn-bd # InterPro IPR006132 Asp/Orn_carbamoyltranf_P-bd # InterPro IPR024904 OTCase_ArgI # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00330 Arginine and proline metabolism # MISCELLANEOUS ArgF might be the product of a relatively recent event (duplication or transposition) peculiar to E.coli strain K- 12. {ECO:0000305|PubMed 4558857}. # Organism OTC2_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-arginine biosynthesis; L- arginine from L-ornithine and carbamoyl phosphate step 1/3. # PATRIC 32115667 VBIEscCol129921_0277 # PIR A64753 OWECF # PRINTS PR00100 AOTCASE # PRINTS PR00102 OTCASE # PROSITE PS00097 CARBAMOYLTRANSFERASE # Pfam PF00185 OTCace # Pfam PF02729 OTCace_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName OTC2_ECOLI Ornithine carbamoyltransferase chain F # RefSeq NP_414807 NC_000913.3 # RefSeq WP_001281825 NZ_LN832404.1 # SIMILARITY Belongs to the ATCase/OTCase family. {ECO 0000305}. # SUBCELLULAR LOCATION OTC2_ECOLI Cytoplasm. # SUBUNIT OTC2_ECOLI In E.coli strain K12, trimer of identical or non- identical chains are composed of ArgI (I) and/or ArgF (F). The trimer has the following composition FFI, FFF, FII, III. E.coli strains B and W, which are known to contain only ArgI, produce only a trimer of identical chains (III). {ECO 0000269|PubMed 4558857, ECO 0000269|PubMed 789338}. # SUPFAM SSF53671 SSF53671 # TIGRFAMs TIGR00658 orni_carb_tr # UniPathway UPA00068 UER00112 # eggNOG COG0078 LUCA # eggNOG ENOG4105DBV Bacteria BLAST swissprot:OTC2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:OTC2_ECOLI BioCyc ECOL316407:JW0266-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0266-MONOMER BioCyc EcoCyc:CHAINF-MONOMER http://biocyc.org/getid?id=EcoCyc:CHAINF-MONOMER BioCyc MetaCyc:CHAINF-MONOMER http://biocyc.org/getid?id=MetaCyc:CHAINF-MONOMER COG COG0078 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0078 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/12.15.6277 http://dx.doi.org/10.1093/nar/12.15.6277 DOI 10.1111/j.1432-1033.1972.tb01814.x http://dx.doi.org/10.1111/j.1432-1033.1972.tb01814.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.3.3 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.3.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EMBL X00759 http://www.ebi.ac.uk/ena/data/view/X00759 ENZYME 2.1.3.3 http://enzyme.expasy.org/EC/2.1.3.3 EchoBASE EB0065 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0065 EcoGene EG10067 http://www.ecogene.org/geneInfo.php?eg_id=EG10067 EnsemblBacteria AAC73376 http://www.ensemblgenomes.org/id/AAC73376 EnsemblBacteria AAC73376 http://www.ensemblgenomes.org/id/AAC73376 EnsemblBacteria BAE76057 http://www.ensemblgenomes.org/id/BAE76057 EnsemblBacteria BAE76057 http://www.ensemblgenomes.org/id/BAE76057 EnsemblBacteria BAE76057 http://www.ensemblgenomes.org/id/BAE76057 EnsemblBacteria b0273 http://www.ensemblgenomes.org/id/b0273 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004585 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004585 GO_function GO:0016597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016597 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0000050 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000050 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0042450 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042450 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0071941 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071941 Gene3D 3.40.50.1370 http://www.cathdb.info/version/latest/superfamily/3.40.50.1370 GeneID 944844 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944844 HAMAP MF_01109 http://hamap.expasy.org/unirule/MF_01109 HOGENOM HOG000022686 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000022686&db=HOGENOM6 InParanoid P06960 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P06960 IntAct P06960 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P06960* IntEnz 2.1.3.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.3.3 InterPro IPR002292 http://www.ebi.ac.uk/interpro/entry/IPR002292 InterPro IPR006130 http://www.ebi.ac.uk/interpro/entry/IPR006130 InterPro IPR006131 http://www.ebi.ac.uk/interpro/entry/IPR006131 InterPro IPR006132 http://www.ebi.ac.uk/interpro/entry/IPR006132 InterPro IPR024904 http://www.ebi.ac.uk/interpro/entry/IPR024904 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0266 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0266 KEGG_Gene eco:b0273 http://www.genome.jp/dbget-bin/www_bget?eco:b0273 KEGG_Orthology KO:K00611 http://www.genome.jp/dbget-bin/www_bget?KO:K00611 KEGG_Pathway ko00330 http://www.genome.jp/kegg-bin/show_pathway?ko00330 KEGG_Reaction rn:R01398 http://www.genome.jp/dbget-bin/www_bget?rn:R01398 OMA AAPRELW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AAPRELW PRINTS PR00100 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00100 PRINTS PR00102 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00102 PROSITE PS00097 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00097 PSORT swissprot:OTC2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:OTC2_ECOLI PSORT-B swissprot:OTC2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:OTC2_ECOLI PSORT2 swissprot:OTC2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:OTC2_ECOLI Pfam PF00185 http://pfam.xfam.org/family/PF00185 Pfam PF02729 http://pfam.xfam.org/family/PF02729 Phobius swissprot:OTC2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:OTC2_ECOLI PhylomeDB P06960 http://phylomedb.org/?seqid=P06960 ProteinModelPortal P06960 http://www.proteinmodelportal.org/query/uniprot/P06960 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3968036 http://www.ncbi.nlm.nih.gov/pubmed/3968036 PubMed 4558857 http://www.ncbi.nlm.nih.gov/pubmed/4558857 PubMed 6382166 http://www.ncbi.nlm.nih.gov/pubmed/6382166 PubMed 789338 http://www.ncbi.nlm.nih.gov/pubmed/789338 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414807 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414807 RefSeq WP_001281825 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001281825 SMR P06960 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P06960 STRING 511145.b0273 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0273&targetmode=cogs STRING COG0078 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0078&targetmode=cogs SUPFAM SSF53671 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53671 SWISS-2DPAGE P06960 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P06960 TIGRFAMs TIGR00658 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00658 UniProtKB OTC2_ECOLI http://www.uniprot.org/uniprot/OTC2_ECOLI UniProtKB-AC P06960 http://www.uniprot.org/uniprot/P06960 charge swissprot:OTC2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:OTC2_ECOLI eggNOG COG0078 http://eggnogapi.embl.de/nog_data/html/tree/COG0078 eggNOG ENOG4105DBV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DBV epestfind swissprot:OTC2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:OTC2_ECOLI garnier swissprot:OTC2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:OTC2_ECOLI helixturnhelix swissprot:OTC2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:OTC2_ECOLI hmoment swissprot:OTC2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:OTC2_ECOLI iep swissprot:OTC2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:OTC2_ECOLI inforesidue swissprot:OTC2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:OTC2_ECOLI octanol swissprot:OTC2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:OTC2_ECOLI pepcoil swissprot:OTC2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:OTC2_ECOLI pepdigest swissprot:OTC2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:OTC2_ECOLI pepinfo swissprot:OTC2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:OTC2_ECOLI pepnet swissprot:OTC2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:OTC2_ECOLI pepstats swissprot:OTC2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:OTC2_ECOLI pepwheel swissprot:OTC2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:OTC2_ECOLI pepwindow swissprot:OTC2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:OTC2_ECOLI sigcleave swissprot:OTC2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:OTC2_ECOLI ## Database ID URL or Descriptions # BioGrid 4261492 16 # CATALYTIC ACTIVITY YAGR_ECOLI Hypoxanthine + NAD(+) + H(2)O = xanthine + NADH. # CATALYTIC ACTIVITY YAGR_ECOLI Xanthine + NAD(+) + H(2)O = urate + NADH. # COFACTOR YAGR_ECOLI Name=Mo-molybdopterin; Xref=ChEBI CHEBI 71302; Evidence={ECO 0000250}; Note=Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit. {ECO 0000250}; # EcoGene EG13557 yagR # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_component GO:0042597 periplasmic space; NAS:EcoCyc. # GO_function GO:0004854 xanthine dehydrogenase activity; IBA:GO_Central. # GO_function GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors; IDA:EcoCyc. # GO_function GO:0030151 molybdenum ion binding; IDA:EcoCyc. # GO_function GO:0050660 flavin adenine dinucleotide binding; IBA:GO_Central. # GO_process GO:0006166 purine ribonucleoside salvage; IEA:UniProtKB-KW. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0009115 xanthine catabolic process; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.30.365.10 -; 6. # Gene3D 3.90.1170.50 -; 1. # IntAct P77489 10 # InterPro IPR000674 Ald_Oxase/Xan_DH_a/b # InterPro IPR008274 AldOxase/xan_DH_Mopterin-bd # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # Organism YAGR_ECOLI Escherichia coli (strain K12) # PATRIC 32115691 VBIEscCol129921_0288 # PDB 5G5G X-ray; 1.70 A; C=1-732 # PDB 5G5H X-ray; 2.30 A; C=1-732 # PIR D64754 D64754 # Pfam PF01315 Ald_Xan_dh_C # Pfam PF02738 Ald_Xan_dh_C2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAGR_ECOLI Putative xanthine dehydrogenase YagR molybdenum-binding subunit # RefSeq NP_414818 NC_000913.3 # RefSeq WP_000667026 NZ_LN832404.1 # SIMILARITY Belongs to the xanthine dehydrogenase family. {ECO 0000305}. # SMART SM01008 Ald_Xan_dh_C # SUBUNIT Heterotrimer of YagR, YagS and YagT. {ECO 0000305}. # SUPFAM SSF54665 SSF54665 # SUPFAM SSF56003 SSF56003 # eggNOG COG1529 LUCA # eggNOG ENOG4105C7W Bacteria BLAST swissprot:YAGR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAGR_ECOLI BioCyc ECOL316407:JW0278-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0278-MONOMER BioCyc EcoCyc:G6155-MONOMER http://biocyc.org/getid?id=EcoCyc:G6155-MONOMER BioCyc MetaCyc:G6155-MONOMER http://biocyc.org/getid?id=MetaCyc:G6155-MONOMER COG COG1529 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1529 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.17.1.4 http://www.genome.jp/dbget-bin/www_bget?EC:1.17.1.4 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 ENZYME 1.17.1.4 http://enzyme.expasy.org/EC/1.17.1.4 EchoBASE EB3327 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3327 EcoGene EG13557 http://www.ecogene.org/geneInfo.php?eg_id=EG13557 EnsemblBacteria AAC73387 http://www.ensemblgenomes.org/id/AAC73387 EnsemblBacteria AAC73387 http://www.ensemblgenomes.org/id/AAC73387 EnsemblBacteria BAE76068 http://www.ensemblgenomes.org/id/BAE76068 EnsemblBacteria BAE76068 http://www.ensemblgenomes.org/id/BAE76068 EnsemblBacteria BAE76068 http://www.ensemblgenomes.org/id/BAE76068 EnsemblBacteria b0284 http://www.ensemblgenomes.org/id/b0284 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0004854 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004854 GO_function GO:0016903 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016903 GO_function GO:0030151 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030151 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_process GO:0006166 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006166 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0009115 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009115 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.30.365.10 http://www.cathdb.info/version/latest/superfamily/3.30.365.10 Gene3D 3.90.1170.50 http://www.cathdb.info/version/latest/superfamily/3.90.1170.50 GeneID 944961 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944961 HOGENOM HOG000244716 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000244716&db=HOGENOM6 InParanoid P77489 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77489 IntAct P77489 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77489* IntEnz 1.17.1.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.17.1.4 InterPro IPR000674 http://www.ebi.ac.uk/interpro/entry/IPR000674 InterPro IPR008274 http://www.ebi.ac.uk/interpro/entry/IPR008274 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0278 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0278 KEGG_Gene eco:b0284 http://www.genome.jp/dbget-bin/www_bget?eco:b0284 KEGG_Orthology KO:K11177 http://www.genome.jp/dbget-bin/www_bget?KO:K11177 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Reaction rn:R01768 http://www.genome.jp/dbget-bin/www_bget?rn:R01768 KEGG_Reaction rn:R02103 http://www.genome.jp/dbget-bin/www_bget?rn:R02103 OMA VITYKNA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VITYKNA PDB 5G5G http://www.ebi.ac.uk/pdbe-srv/view/entry/5G5G PDB 5G5H http://www.ebi.ac.uk/pdbe-srv/view/entry/5G5H PDBsum 5G5G http://www.ebi.ac.uk/pdbsum/5G5G PDBsum 5G5H http://www.ebi.ac.uk/pdbsum/5G5H PSORT swissprot:YAGR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAGR_ECOLI PSORT-B swissprot:YAGR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAGR_ECOLI PSORT2 swissprot:YAGR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAGR_ECOLI Pfam PF01315 http://pfam.xfam.org/family/PF01315 Pfam PF02738 http://pfam.xfam.org/family/PF02738 Phobius swissprot:YAGR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAGR_ECOLI PhylomeDB P77489 http://phylomedb.org/?seqid=P77489 ProteinModelPortal P77489 http://www.proteinmodelportal.org/query/uniprot/P77489 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414818 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414818 RefSeq WP_000667026 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000667026 SMART SM01008 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01008 SMR P77489 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77489 STRING 511145.b0284 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0284&targetmode=cogs STRING COG1529 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1529&targetmode=cogs SUPFAM SSF54665 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54665 SUPFAM SSF56003 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56003 UniProtKB YAGR_ECOLI http://www.uniprot.org/uniprot/YAGR_ECOLI UniProtKB-AC P77489 http://www.uniprot.org/uniprot/P77489 charge swissprot:YAGR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAGR_ECOLI eggNOG COG1529 http://eggnogapi.embl.de/nog_data/html/tree/COG1529 eggNOG ENOG4105C7W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C7W epestfind swissprot:YAGR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAGR_ECOLI garnier swissprot:YAGR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAGR_ECOLI helixturnhelix swissprot:YAGR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAGR_ECOLI hmoment swissprot:YAGR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAGR_ECOLI iep swissprot:YAGR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAGR_ECOLI inforesidue swissprot:YAGR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAGR_ECOLI octanol swissprot:YAGR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAGR_ECOLI pepcoil swissprot:YAGR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAGR_ECOLI pepdigest swissprot:YAGR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAGR_ECOLI pepinfo swissprot:YAGR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAGR_ECOLI pepnet swissprot:YAGR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAGR_ECOLI pepstats swissprot:YAGR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAGR_ECOLI pepwheel swissprot:YAGR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAGR_ECOLI pepwindow swissprot:YAGR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAGR_ECOLI sigcleave swissprot:YAGR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAGR_ECOLI ## Database ID URL or Descriptions # AltName CHAA_ECOLI Na(+)/H(+) exchanger # BioGrid 4260120 10 # ENZYME REGULATION Pronounced pH dependence. Inhibited by magnesium. {ECO:0000269|PubMed 8496184}. # EcoGene EG11753 chaA # FUNCTION CHAA_ECOLI Sodium exporter that functions mainly at alkaline pH. Can also function as a potassium/proton and calcium/proton antiporter at alkaline pH. Does not play a major role in calcium export. {ECO 0000269|PubMed 16687400, ECO 0000269|PubMed 18342619, ECO 0000269|PubMed 8021217, ECO 0000269|PubMed 8496184, ECO 0000269|PubMed 9518629}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoliWiki. # GO_function CHAA_ECOLI GO 0015385 sodium proton antiporter activity; IDA EcoCyc. # GO_function CHAA_ECOLI GO 0015386 potassium proton antiporter activity; IDA EcoCyc. # GO_process GO:0006814 sodium ion transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR004713 CaH_exchang # InterPro IPR004837 NaCa_Exmemb # KEGG_Brite ko02000 Transporters # Organism CHAA_ECOLI Escherichia coli (strain K12) # PATRIC 32117690 VBIEscCol129921_1267 # PIR A46716 A46716 # Pfam PF01699 Na_Ca_ex; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Sodium-potassium/proton antiporter ChaA {ECO 0000305} # RefSeq NP_415734 NC_000913.3 # RefSeq WP_000063607 NZ_LN832404.1 # SIMILARITY Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. {ECO 0000305}. # SUBCELLULAR LOCATION CHAA_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # TCDB 2.A.19.1:the ca(2+) cation antiporter (caca) family # TIGRFAMs TIGR00846 caca2 # eggNOG COG0387 LUCA # eggNOG ENOG4105EWV Bacteria BLAST swissprot:CHAA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CHAA_ECOLI BioCyc ECOL316407:JW1207-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1207-MONOMER BioCyc EcoCyc:CHAA-MONOMER http://biocyc.org/getid?id=EcoCyc:CHAA-MONOMER BioCyc MetaCyc:CHAA-MONOMER http://biocyc.org/getid?id=MetaCyc:CHAA-MONOMER COG COG0387 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0387 DOI 10.1016/S0005-2728(97)00102-3 http://dx.doi.org/10.1016/S0005-2728(97)00102-3 DOI 10.1016/j.bbamem.2008.02.006 http://dx.doi.org/10.1016/j.bbamem.2008.02.006 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M600333200 http://dx.doi.org/10.1074/jbc.M600333200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L28709 http://www.ebi.ac.uk/ena/data/view/L28709 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1703 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1703 EcoGene EG11753 http://www.ecogene.org/geneInfo.php?eg_id=EG11753 EnsemblBacteria AAC74300 http://www.ensemblgenomes.org/id/AAC74300 EnsemblBacteria AAC74300 http://www.ensemblgenomes.org/id/AAC74300 EnsemblBacteria BAA36074 http://www.ensemblgenomes.org/id/BAA36074 EnsemblBacteria BAA36074 http://www.ensemblgenomes.org/id/BAA36074 EnsemblBacteria BAA36074 http://www.ensemblgenomes.org/id/BAA36074 EnsemblBacteria b1216 http://www.ensemblgenomes.org/id/b1216 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015385 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015385 GO_function GO:0015386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015386 GO_process GO:0006814 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 945790 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945790 HOGENOM HOG000197726 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000197726&db=HOGENOM6 InParanoid P31801 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31801 InterPro IPR004713 http://www.ebi.ac.uk/interpro/entry/IPR004713 InterPro IPR004837 http://www.ebi.ac.uk/interpro/entry/IPR004837 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1207 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1207 KEGG_Gene eco:b1216 http://www.genome.jp/dbget-bin/www_bget?eco:b1216 KEGG_Orthology KO:K07300 http://www.genome.jp/dbget-bin/www_bget?KO:K07300 OMA PEMIVMV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PEMIVMV PSORT swissprot:CHAA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CHAA_ECOLI PSORT-B swissprot:CHAA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CHAA_ECOLI PSORT2 swissprot:CHAA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CHAA_ECOLI Pfam PF01699 http://pfam.xfam.org/family/PF01699 Phobius swissprot:CHAA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CHAA_ECOLI PhylomeDB P31801 http://phylomedb.org/?seqid=P31801 ProteinModelPortal P31801 http://www.proteinmodelportal.org/query/uniprot/P31801 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16687400 http://www.ncbi.nlm.nih.gov/pubmed/16687400 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18342619 http://www.ncbi.nlm.nih.gov/pubmed/18342619 PubMed 8021217 http://www.ncbi.nlm.nih.gov/pubmed/8021217 PubMed 8496184 http://www.ncbi.nlm.nih.gov/pubmed/8496184 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9518629 http://www.ncbi.nlm.nih.gov/pubmed/9518629 RefSeq NP_415734 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415734 RefSeq WP_000063607 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000063607 STRING 511145.b1216 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1216&targetmode=cogs STRING COG0387 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0387&targetmode=cogs TCDB 2.A.19.1 http://www.tcdb.org/search/result.php?tc=2.A.19.1 TIGRFAMs TIGR00846 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00846 UniProtKB CHAA_ECOLI http://www.uniprot.org/uniprot/CHAA_ECOLI UniProtKB-AC P31801 http://www.uniprot.org/uniprot/P31801 charge swissprot:CHAA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CHAA_ECOLI eggNOG COG0387 http://eggnogapi.embl.de/nog_data/html/tree/COG0387 eggNOG ENOG4105EWV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EWV epestfind swissprot:CHAA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CHAA_ECOLI garnier swissprot:CHAA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CHAA_ECOLI helixturnhelix swissprot:CHAA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CHAA_ECOLI hmoment swissprot:CHAA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CHAA_ECOLI iep swissprot:CHAA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CHAA_ECOLI inforesidue swissprot:CHAA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CHAA_ECOLI octanol swissprot:CHAA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CHAA_ECOLI pepcoil swissprot:CHAA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CHAA_ECOLI pepdigest swissprot:CHAA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CHAA_ECOLI pepinfo swissprot:CHAA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CHAA_ECOLI pepnet swissprot:CHAA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CHAA_ECOLI pepstats swissprot:CHAA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CHAA_ECOLI pepwheel swissprot:CHAA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CHAA_ECOLI pepwindow swissprot:CHAA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CHAA_ECOLI sigcleave swissprot:CHAA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CHAA_ECOLI ## Database ID URL or Descriptions # AltName ADA_ECOLI Methylphosphotriester-DNA methyltransferase # AltName ADA_ECOLI Methylphosphotriester-DNA methyltransferase # AltName ADA_ECOLI O6-methylguanine-DNA alkyltransferase # AltName ADA_ECOLI Regulatory protein of adaptive response # AltName ADA_ECOLI Regulatory protein of adaptive response # BioGrid 4261923 99 # CATALYTIC ACTIVITY ADA_ECOLI DNA (containing 6-O-methylguanine) + protein L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L- cysteine. {ECO 0000255|PROSITE-ProRule PRU10017, ECO 0000269|PubMed 2987862}. # CATALYTIC ACTIVITY DNA (containing Sp-methylphosphotriester) + protein L-cysteine = DNA (without Sp-methylphosphotriester) + protein S-methyl-L-cysteine. {ECO:0000269|PubMed 2987862}. # CDD cd06445 ATase # COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI 29105; Note=Binds 1 zinc ion per subunit.; # DOMAIN ADA_ECOLI Consists of two domains. The 20 kDa N-terminal domain repairs the Sp diastereomer of methylphosphotriesters and, in its methylated form, binds DNA in a sequence-specific manner. The 19 kDa C-terminal domain repairs the mutagenic lesions O6- methylguanine. Each domain retains its activity when separated form the other. {ECO 0000269|PubMed 3162236}. # EcoGene EG10029 ada # FUNCTION ADA_ECOLI Is involved in the adaptive response to alkylation damage in DNA caused by alkylating agents. Repairs O6- methylguanine and 04-methylthymine residues in alkylated DNA by a direct and irreversible transfer of the methyl group from the base to one of its own cysteine residues (Cys-321). Also specifically repairs the Sp diastereomer of DNA methylphosphotriester lesions by the same mechanism, although the methyl transfer occurs onto a different cysteine residue (Cys-38). Cannot demethylate the other diastereomer, Rp-methylphosphotriester. {ECO 0000269|PubMed 2987862}. # FUNCTION ADA_ECOLI The methylation of Ada by methylphosphotriesters in DNA leads to its activation as a transcriptional regulator that activates the transcription of its own gene, ada, and other alkylation resistance genes, alkA, alkB and aidB. {ECO 0000269|PubMed 2987862}. # GO_function ADA_ECOLI GO 0043833 methylamine-specific methylcobalamin coenzyme M methyltransferase activity; IEA UniProtKB-EC. # GO_function ADA_ECOLI GO 0043851 methanol-specific methylcobalamin coenzyme M methyltransferase activity; IEA UniProtKB-EC. # GO_function GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0003684 damaged DNA binding; IBA:GO_Central. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_function GO:0003908 methylated-DNA-[protein]-cysteine S-methyltransferase activity; IDA:EcoliWiki. # GO_function GO:0004809 tRNA (guanine-N2-)-methyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0008174 mRNA methyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0008270 zinc ion binding; IDA:EcoliWiki. # GO_function GO:0008425 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0008650 rRNA (uridine-2'-O-)-methyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0008988 rRNA (adenine-N6-)-methyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0009008 DNA-methyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0009019 tRNA (guanine-N1-)-methyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016205 selenocysteine methyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016279 protein-lysine N-methyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016428 tRNA (cytosine-5-)-methyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016435 rRNA (guanine) methyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0018423 protein C-terminal leucine carboxyl O-methyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0018707 1-phenanthrol methyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0019702 protein-arginine N5-methyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0030792 methylarsonite methyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0034541 dimethylarsinite methyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0034807 4,5-dihydroxybenzo(a)pyrene methyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0034931 1-hydroxypyrene methyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0034933 1-hydroxy-6-methoxypyrene methyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0043565 sequence-specific DNA binding; IEA:InterPro. # GO_function GO:0043770 demethylmenaquinone methyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0043776 cobalt-precorrin-6B C5-methyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0043777 cobalt-precorrin-7 C15-methyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0043780 cobalt-precorrin-5B C1-methyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0043782 cobalt-precorrin-3 C17-methyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0043791 dimethylamine methyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0043803 hydroxyneurosporene-O-methyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0043827 tRNA (adenine-57, 58-N(1)-) methyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0043834 trimethylamine methyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0043852 monomethylamine methyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0051994 P-methyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0052624 2-phytyl-1,4-naphthoquinone methyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0052665 tRNA (uracil-2'-O-)-methyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0052666 tRNA (cytosine-2'-O-)-methyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0052667 phosphomethylethanolamine N-methyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0052735 tRNA (cytosine-3-)-methyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0070677 rRNA (cytosine-2'-O-)-methyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0071424 rRNA (cytosine-N4-)-methyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0080012 trihydroxyferuloyl spermidine O-methyltransferase activity; IEA:UniProtKB-EC. # GO_process GO:0006307 DNA dealkylation involved in DNA repair; IDA:EcoliWiki. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0080111 DNA demethylation; IDA:EcoliWiki. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0008168 methyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # Gene3D 1.10.10.60 -; 1. # Gene3D 3.40.10.10 -; 1. # INDUCTION ADA_ECOLI Up-regulated by methylated Ada itself in response to the exposure to alkylating agents. # INTERACTION ADA_ECOLI P69931 hda; NbExp=3; IntAct=EBI-1119501, EBI-545453; # IntAct P06134 13 # InterPro IPR001497 MethylDNA_cys_MeTrfase_AS # InterPro IPR004026 Ada_DNA_repair_Zn-bd # InterPro IPR008332 MethylG_MeTrfase_N # InterPro IPR009057 Homeodomain-like # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR014048 MethylDNA_cys_MeTrfase_DNA-bd # InterPro IPR016221 Bifunct_regulatory_prot_Ada # InterPro IPR018060 HTH_AraC # InterPro IPR018062 HTH_AraC-typ_CS # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03000 Transcription factors # KEGG_Brite ko03400 DNA repair and recombination proteins # MISCELLANEOUS ADA_ECOLI This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles. # Organism ADA_ECOLI Escherichia coli (strain K12) # PATRIC 32119785 VBIEscCol129921_2302 # PDB 1ADN NMR; -; A=1-92 # PDB 1EYF NMR; -; A=1-92 # PDB 1SFE X-ray; 2.10 A; A=175-354 # PDB 1U8B X-ray; 2.10 A; A=9-139 # PDB 1WPK NMR; -; A=1-146 # PDB 1ZGW NMR; -; A=1-139 # PIR C64991 XYECO2 # PIRSF PIRSF000409 Ada # PROSITE PS00041 HTH_ARAC_FAMILY_1; 2 # PROSITE PS00374 MGMT # PROSITE PS01124 HTH_ARAC_FAMILY_2 # Pfam PF01035 DNA_binding_1 # Pfam PF02805 Ada_Zn_binding # Pfam PF02870 Methyltransf_1N # Pfam PF12833 HTH_18 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ADA_ECOLI Bifunctional transcriptional activator/DNA repair enzyme Ada # RecName ADA_ECOLI Methylated-DNA--protein-cysteine methyltransferase # RecName ADA_ECOLI Methylphosphotriester-DNA--protein-cysteine S-methyltransferase # RefSeq NP_416717 NC_000913.3 # RefSeq WP_000710375 NZ_LN832404.1 # SIMILARITY Contains 1 HTH araC/xylS-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00593}. # SIMILARITY In the C-terminal section; belongs to the MGMT family. {ECO 0000305}. # SMART SM00342 HTH_ARAC # SUPFAM SSF46689 SSF46689 # SUPFAM SSF46767 SSF46767 # SUPFAM SSF53155 SSF53155 # SUPFAM SSF57884 SSF57884 # TIGRFAMs TIGR00589 ogt # eggNOG COG0350 LUCA # eggNOG COG2169 LUCA # eggNOG ENOG4105K85 Bacteria BLAST swissprot:ADA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ADA_ECOLI BioCyc ECOL316407:JW2201-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2201-MONOMER BioCyc EcoCyc:PD00230 http://biocyc.org/getid?id=EcoCyc:PD00230 BioCyc MetaCyc:PD00230 http://biocyc.org/getid?id=MetaCyc:PD00230 COG COG0350 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0350 COG COG2169 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2169 DIP DIP-9055N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9055N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0014-5793(93)81351-Y http://dx.doi.org/10.1016/0014-5793(93)81351-Y DOI 10.1016/0092-8674(86)90396-X http://dx.doi.org/10.1016/0092-8674(86)90396-X DOI 10.1016/j.molcel.2005.08.013 http://dx.doi.org/10.1016/j.molcel.2005.08.013 DOI 10.1021/bi00134a002 http://dx.doi.org/10.1021/bi00134a002 DOI 10.1021/bi002109p http://dx.doi.org/10.1021/bi002109p DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.82.9.2688 http://dx.doi.org/10.1073/pnas.82.9.2688 DOI 10.1073/pnas.83.17.6297 http://dx.doi.org/10.1073/pnas.83.17.6297 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/nar/13.8.2683 http://dx.doi.org/10.1093/nar/13.8.2683 DOI 10.1093/nar/22.9.1613 http://dx.doi.org/10.1093/nar/22.9.1613 DOI 10.1110/ps.051786306 http://dx.doi.org/10.1110/ps.051786306 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1126/science.8395079 http://dx.doi.org/10.1126/science.8395079 EC_number EC:2.1.1.63 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.63 EC_number EC:2.1.1.n11 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.n11 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J02607 http://www.ebi.ac.uk/ena/data/view/J02607 EMBL M10211 http://www.ebi.ac.uk/ena/data/view/M10211 EMBL M10315 http://www.ebi.ac.uk/ena/data/view/M10315 EMBL M13155 http://www.ebi.ac.uk/ena/data/view/M13155 EMBL M13828 http://www.ebi.ac.uk/ena/data/view/M13828 EMBL U00008 http://www.ebi.ac.uk/ena/data/view/U00008 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.1.1.63 http://enzyme.expasy.org/EC/2.1.1.63 ENZYME 2.1.1.n11 http://enzyme.expasy.org/EC/2.1.1.n11 EchoBASE EB0028 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0028 EcoGene EG10029 http://www.ecogene.org/geneInfo.php?eg_id=EG10029 EnsemblBacteria AAC75273 http://www.ensemblgenomes.org/id/AAC75273 EnsemblBacteria AAC75273 http://www.ensemblgenomes.org/id/AAC75273 EnsemblBacteria BAA15996 http://www.ensemblgenomes.org/id/BAA15996 EnsemblBacteria BAA15996 http://www.ensemblgenomes.org/id/BAA15996 EnsemblBacteria BAA15996 http://www.ensemblgenomes.org/id/BAA15996 EnsemblBacteria b2213 http://www.ensemblgenomes.org/id/b2213 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000179 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000179 GO_function GO:0003684 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003684 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0003908 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003908 GO_function GO:0004809 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004809 GO_function GO:0008174 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008174 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0008425 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008425 GO_function GO:0008650 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008650 GO_function GO:0008988 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008988 GO_function GO:0009008 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009008 GO_function GO:0009019 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009019 GO_function GO:0009383 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009383 GO_function GO:0016205 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016205 GO_function GO:0016279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016279 GO_function GO:0016428 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016428 GO_function GO:0016435 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016435 GO_function GO:0018423 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018423 GO_function GO:0018707 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018707 GO_function GO:0019702 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019702 GO_function GO:0030792 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030792 GO_function GO:0034541 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034541 GO_function GO:0034807 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034807 GO_function GO:0034931 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034931 GO_function GO:0034933 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034933 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_function GO:0043770 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043770 GO_function GO:0043776 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043776 GO_function GO:0043777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043777 GO_function GO:0043780 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043780 GO_function GO:0043782 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043782 GO_function GO:0043791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043791 GO_function GO:0043803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043803 GO_function GO:0043827 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043827 GO_function GO:0043833 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043833 GO_function GO:0043834 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043834 GO_function GO:0043851 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043851 GO_function GO:0043852 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043852 GO_function GO:0051994 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051994 GO_function GO:0052624 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052624 GO_function GO:0052665 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052665 GO_function GO:0052666 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052666 GO_function GO:0052667 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052667 GO_function GO:0052735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052735 GO_function GO:0070677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070677 GO_function GO:0071424 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071424 GO_function GO:0080012 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0080012 GO_process GO:0006307 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006307 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0080111 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0080111 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 Gene3D 3.40.10.10 http://www.cathdb.info/version/latest/superfamily/3.40.10.10 GeneID 946710 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946710 HOGENOM HOG000244139 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000244139&db=HOGENOM6 InParanoid P06134 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P06134 IntAct P06134 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P06134* IntEnz 2.1.1.63 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.63 IntEnz 2.1.1.n11 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.n11 InterPro IPR001497 http://www.ebi.ac.uk/interpro/entry/IPR001497 InterPro IPR004026 http://www.ebi.ac.uk/interpro/entry/IPR004026 InterPro IPR008332 http://www.ebi.ac.uk/interpro/entry/IPR008332 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR014048 http://www.ebi.ac.uk/interpro/entry/IPR014048 InterPro IPR016221 http://www.ebi.ac.uk/interpro/entry/IPR016221 InterPro IPR018060 http://www.ebi.ac.uk/interpro/entry/IPR018060 InterPro IPR018062 http://www.ebi.ac.uk/interpro/entry/IPR018062 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW2201 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2201 KEGG_Gene eco:b2213 http://www.genome.jp/dbget-bin/www_bget?eco:b2213 KEGG_Orthology KO:K10778 http://www.genome.jp/dbget-bin/www_bget?KO:K10778 MINT MINT-1310041 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1310041 OMA RFAIGQC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RFAIGQC PDB 1ADN http://www.ebi.ac.uk/pdbe-srv/view/entry/1ADN PDB 1EYF http://www.ebi.ac.uk/pdbe-srv/view/entry/1EYF PDB 1SFE http://www.ebi.ac.uk/pdbe-srv/view/entry/1SFE PDB 1U8B http://www.ebi.ac.uk/pdbe-srv/view/entry/1U8B PDB 1WPK http://www.ebi.ac.uk/pdbe-srv/view/entry/1WPK PDB 1ZGW http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZGW PDBsum 1ADN http://www.ebi.ac.uk/pdbsum/1ADN PDBsum 1EYF http://www.ebi.ac.uk/pdbsum/1EYF PDBsum 1SFE http://www.ebi.ac.uk/pdbsum/1SFE PDBsum 1U8B http://www.ebi.ac.uk/pdbsum/1U8B PDBsum 1WPK http://www.ebi.ac.uk/pdbsum/1WPK PDBsum 1ZGW http://www.ebi.ac.uk/pdbsum/1ZGW PROSITE PS00041 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00041 PROSITE PS00374 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00374 PROSITE PS01124 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01124 PSORT swissprot:ADA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ADA_ECOLI PSORT-B swissprot:ADA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ADA_ECOLI PSORT2 swissprot:ADA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ADA_ECOLI Pfam PF01035 http://pfam.xfam.org/family/PF01035 Pfam PF02805 http://pfam.xfam.org/family/PF02805 Pfam PF02870 http://pfam.xfam.org/family/PF02870 Pfam PF12833 http://pfam.xfam.org/family/PF12833 Phobius swissprot:ADA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ADA_ECOLI PhylomeDB P06134 http://phylomedb.org/?seqid=P06134 ProteinModelPortal P06134 http://www.proteinmodelportal.org/query/uniprot/P06134 PubMed 11284682 http://www.ncbi.nlm.nih.gov/pubmed/11284682 PubMed 1581309 http://www.ncbi.nlm.nih.gov/pubmed/1581309 PubMed 16209950 http://www.ncbi.nlm.nih.gov/pubmed/16209950 PubMed 16452614 http://www.ncbi.nlm.nih.gov/pubmed/16452614 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2982792 http://www.ncbi.nlm.nih.gov/pubmed/2982792 PubMed 2987251 http://www.ncbi.nlm.nih.gov/pubmed/2987251 PubMed 2987862 http://www.ncbi.nlm.nih.gov/pubmed/2987862 PubMed 3009022 http://www.ncbi.nlm.nih.gov/pubmed/3009022 PubMed 3162236 http://www.ncbi.nlm.nih.gov/pubmed/3162236 PubMed 3529081 http://www.ncbi.nlm.nih.gov/pubmed/3529081 PubMed 3536913 http://www.ncbi.nlm.nih.gov/pubmed/3536913 PubMed 3887409 http://www.ncbi.nlm.nih.gov/pubmed/3887409 PubMed 8156986 http://www.ncbi.nlm.nih.gov/pubmed/8156986 PubMed 8202360 http://www.ncbi.nlm.nih.gov/pubmed/8202360 PubMed 8395079 http://www.ncbi.nlm.nih.gov/pubmed/8395079 PubMed 8500619 http://www.ncbi.nlm.nih.gov/pubmed/8500619 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_416717 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416717 RefSeq WP_000710375 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000710375 SMART SM00342 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00342 SMR P06134 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P06134 STRING 511145.b2213 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2213&targetmode=cogs STRING COG0350 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0350&targetmode=cogs STRING COG2169 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2169&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF46767 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46767 SUPFAM SSF53155 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53155 SUPFAM SSF57884 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF57884 TIGRFAMs TIGR00589 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00589 UniProtKB ADA_ECOLI http://www.uniprot.org/uniprot/ADA_ECOLI UniProtKB-AC P06134 http://www.uniprot.org/uniprot/P06134 charge swissprot:ADA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ADA_ECOLI eggNOG COG0350 http://eggnogapi.embl.de/nog_data/html/tree/COG0350 eggNOG COG2169 http://eggnogapi.embl.de/nog_data/html/tree/COG2169 eggNOG ENOG4105K85 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K85 epestfind swissprot:ADA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ADA_ECOLI garnier swissprot:ADA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ADA_ECOLI helixturnhelix swissprot:ADA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ADA_ECOLI hmoment swissprot:ADA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ADA_ECOLI iep swissprot:ADA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ADA_ECOLI inforesidue swissprot:ADA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ADA_ECOLI octanol swissprot:ADA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ADA_ECOLI pepcoil swissprot:ADA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ADA_ECOLI pepdigest swissprot:ADA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ADA_ECOLI pepinfo swissprot:ADA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ADA_ECOLI pepnet swissprot:ADA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ADA_ECOLI pepstats swissprot:ADA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ADA_ECOLI pepwheel swissprot:ADA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ADA_ECOLI pepwindow swissprot:ADA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ADA_ECOLI sigcleave swissprot:ADA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ADA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262840 338 # CDD cd06306 PBP1_TorT-like # EcoGene EG12616 torT # FUNCTION TORT_ECOLI Upon binding a putative inducer it probably interacts with TorS and allows it to play a role in the induction of the torCAD operon for trimethylamine N-oxide reductase. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_process GO:0006810 transport; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0006810 transport # InterPro IPR001761 Peripla_BP/Lac1_sug-bd_dom # InterPro IPR014301 TMAO_TorT # InterPro IPR028082 Peripla_BP_I # Organism TORT_ECOLI Escherichia coli (strain K12) # PATRIC 32117213 VBIEscCol129921_1030 # PIR H64840 H64840 # Pfam PF00532 Peripla_BP_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TORT_ECOLI Periplasmic protein TorT # RefSeq NP_415514 NC_000913.3 # RefSeq WP_001264933 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial solute-binding protein 2 family. {ECO 0000305}. # SUBCELLULAR LOCATION TORT_ECOLI Periplasm. # SUPFAM SSF53822 SSF53822 # TIGRFAMs TIGR02955 TMAO_TorT # eggNOG COG1879 LUCA # eggNOG ENOG4108SV3 Bacteria BLAST swissprot:TORT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TORT_ECOLI BioCyc ECOL316407:JW0979-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0979-MONOMER BioCyc EcoCyc:TORT-MONOMER http://biocyc.org/getid?id=EcoCyc:TORT-MONOMER COG COG1879 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1879 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X94231 http://www.ebi.ac.uk/ena/data/view/X94231 EchoBASE EB2500 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2500 EcoGene EG12616 http://www.ecogene.org/geneInfo.php?eg_id=EG12616 EnsemblBacteria AAC74079 http://www.ensemblgenomes.org/id/AAC74079 EnsemblBacteria AAC74079 http://www.ensemblgenomes.org/id/AAC74079 EnsemblBacteria BAA36136 http://www.ensemblgenomes.org/id/BAA36136 EnsemblBacteria BAA36136 http://www.ensemblgenomes.org/id/BAA36136 EnsemblBacteria BAA36136 http://www.ensemblgenomes.org/id/BAA36136 EnsemblBacteria b0994 http://www.ensemblgenomes.org/id/b0994 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 946289 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946289 HOGENOM HOG000288658 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000288658&db=HOGENOM6 InterPro IPR001761 http://www.ebi.ac.uk/interpro/entry/IPR001761 InterPro IPR014301 http://www.ebi.ac.uk/interpro/entry/IPR014301 InterPro IPR028082 http://www.ebi.ac.uk/interpro/entry/IPR028082 KEGG_Gene ecj:JW0979 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0979 KEGG_Gene eco:b0994 http://www.genome.jp/dbget-bin/www_bget?eco:b0994 KEGG_Orthology KO:K11930 http://www.genome.jp/dbget-bin/www_bget?KO:K11930 OMA CAIYPHL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CAIYPHL PSORT swissprot:TORT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TORT_ECOLI PSORT-B swissprot:TORT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TORT_ECOLI PSORT2 swissprot:TORT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TORT_ECOLI Pfam PF00532 http://pfam.xfam.org/family/PF00532 Phobius swissprot:TORT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TORT_ECOLI PhylomeDB P38683 http://phylomedb.org/?seqid=P38683 ProteinModelPortal P38683 http://www.proteinmodelportal.org/query/uniprot/P38683 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8083154 http://www.ncbi.nlm.nih.gov/pubmed/8083154 PubMed 8576063 http://www.ncbi.nlm.nih.gov/pubmed/8576063 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415514 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415514 RefSeq WP_001264933 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001264933 SMR P38683 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P38683 STRING 511145.b0994 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0994&targetmode=cogs STRING COG1879 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1879&targetmode=cogs SUPFAM SSF53822 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822 TIGRFAMs TIGR02955 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02955 UniProtKB TORT_ECOLI http://www.uniprot.org/uniprot/TORT_ECOLI UniProtKB-AC P38683 http://www.uniprot.org/uniprot/P38683 charge swissprot:TORT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TORT_ECOLI eggNOG COG1879 http://eggnogapi.embl.de/nog_data/html/tree/COG1879 eggNOG ENOG4108SV3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108SV3 epestfind swissprot:TORT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TORT_ECOLI garnier swissprot:TORT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TORT_ECOLI helixturnhelix swissprot:TORT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TORT_ECOLI hmoment swissprot:TORT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TORT_ECOLI iep swissprot:TORT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TORT_ECOLI inforesidue swissprot:TORT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TORT_ECOLI octanol swissprot:TORT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TORT_ECOLI pepcoil swissprot:TORT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TORT_ECOLI pepdigest swissprot:TORT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TORT_ECOLI pepinfo swissprot:TORT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TORT_ECOLI pepnet swissprot:TORT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TORT_ECOLI pepstats swissprot:TORT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TORT_ECOLI pepwheel swissprot:TORT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TORT_ECOLI pepwindow swissprot:TORT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TORT_ECOLI sigcleave swissprot:TORT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TORT_ECOLI ## Database ID URL or Descriptions # BioGrid 4262371 7 # EcoGene EG13001 yghQ # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR002797 Polysacc_synth # Organism YGHQ_ECOLI Escherichia coli (strain K12) # PATRIC 32121382 VBIEscCol129921_3078 # Pfam PF01943 Polysacc_synt # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGHQ_ECOLI Inner membrane protein YghQ # RefSeq WP_000896895 NZ_CP014272.1 # RefSeq YP_026192 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA69150.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SUBCELLULAR LOCATION YGHQ_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG COG2244 LUCA # eggNOG ENOG4108S55 Bacteria BLAST swissprot:YGHQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGHQ_ECOLI BioCyc ECOL316407:JW5490-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5490-MONOMER BioCyc EcoCyc:G7549-MONOMER http://biocyc.org/getid?id=EcoCyc:G7549-MONOMER DIP DIP-12208N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12208N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2823 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2823 EcoGene EG13001 http://www.ecogene.org/geneInfo.php?eg_id=EG13001 EnsemblBacteria AAT48159 http://www.ensemblgenomes.org/id/AAT48159 EnsemblBacteria AAT48159 http://www.ensemblgenomes.org/id/AAT48159 EnsemblBacteria BAE77044 http://www.ensemblgenomes.org/id/BAE77044 EnsemblBacteria BAE77044 http://www.ensemblgenomes.org/id/BAE77044 EnsemblBacteria BAE77044 http://www.ensemblgenomes.org/id/BAE77044 EnsemblBacteria b2983 http://www.ensemblgenomes.org/id/b2983 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 947716 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947716 HOGENOM HOG000124958 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000124958&db=HOGENOM6 IntAct Q46841 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46841* InterPro IPR002797 http://www.ebi.ac.uk/interpro/entry/IPR002797 KEGG_Gene ecj:JW5490 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5490 KEGG_Gene eco:b2983 http://www.genome.jp/dbget-bin/www_bget?eco:b2983 MINT MINT-1235911 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1235911 OMA LLYMAGQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LLYMAGQ PSORT swissprot:YGHQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGHQ_ECOLI PSORT-B swissprot:YGHQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGHQ_ECOLI PSORT2 swissprot:YGHQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGHQ_ECOLI Pfam PF01943 http://pfam.xfam.org/family/PF01943 Phobius swissprot:YGHQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGHQ_ECOLI ProteinModelPortal Q46841 http://www.proteinmodelportal.org/query/uniprot/Q46841 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000896895 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000896895 RefSeq YP_026192 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026192 STRING 511145.b2983 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2983&targetmode=cogs UniProtKB YGHQ_ECOLI http://www.uniprot.org/uniprot/YGHQ_ECOLI UniProtKB-AC Q46841 http://www.uniprot.org/uniprot/Q46841 charge swissprot:YGHQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGHQ_ECOLI eggNOG COG2244 http://eggnogapi.embl.de/nog_data/html/tree/COG2244 eggNOG ENOG4108S55 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108S55 epestfind swissprot:YGHQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGHQ_ECOLI garnier swissprot:YGHQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGHQ_ECOLI helixturnhelix swissprot:YGHQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGHQ_ECOLI hmoment swissprot:YGHQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGHQ_ECOLI iep swissprot:YGHQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGHQ_ECOLI inforesidue swissprot:YGHQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGHQ_ECOLI octanol swissprot:YGHQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGHQ_ECOLI pepcoil swissprot:YGHQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGHQ_ECOLI pepdigest swissprot:YGHQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGHQ_ECOLI pepinfo swissprot:YGHQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGHQ_ECOLI pepnet swissprot:YGHQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGHQ_ECOLI pepstats swissprot:YGHQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGHQ_ECOLI pepwheel swissprot:YGHQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGHQ_ECOLI pepwindow swissprot:YGHQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGHQ_ECOLI sigcleave swissprot:YGHQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGHQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4259500 7 # EcoGene EG14288 ycgZ # FUNCTION YCGZ_ECOLI Probably a connector protein for RcsB/C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component. # GO_process GO:0071229 cellular response to acid chemical; IEA:InterPro. # GOslim_process GO:0008150 biological_process # INDUCTION YCGZ_ECOLI Expressed constitutively at low levels, slightly induced upon entry into stationary phase at 37 degrees Celsius. Induced by 5-fluorouracil. Strongly induced at 16 and 23 degrees Celsius. Expression is partially dependent on RpoS, it is repressed by YcgE. At 16 degrees Celsius with blue light irradiation, expression of this operon is absolutely dependent on YcgF for relief from YcgE repression. Part of the ycgZ-ymgA-ariR- ymgC operon. {ECO 0000269|PubMed 14527658, ECO 0000269|PubMed 18174134, ECO 0000269|PubMed 19172264, ECO 0000269|PubMed 19240136}. # IntAct P75991 9 # InterPro IPR024753 AriR # Organism YCGZ_ECOLI Escherichia coli (strain K12) # PATRIC 32117565 VBIEscCol129921_1205 # PIR A64862 A64862 # Pfam PF10798 YmgB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCGZ_ECOLI Probable two-component-system connector protein YcgZ # RefSeq NP_415682 NC_000913.3 # RefSeq WP_000554140 NZ_LN832404.1 # eggNOG ENOG4105WKE Bacteria # eggNOG ENOG41123BX LUCA BLAST swissprot:YCGZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCGZ_ECOLI BioCyc ECOL316407:JW1151-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1151-MONOMER BioCyc EcoCyc:G6604-MONOMER http://biocyc.org/getid?id=EcoCyc:G6604-MONOMER DOI 10.1007/s00253-009-1860-8 http://dx.doi.org/10.1007/s00253-009-1860-8 DOI 10.1016/S0923-2508(03)00167-0 http://dx.doi.org/10.1016/S0923-2508(03)00167-0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1099/mic.0.2007/012021-0 http://dx.doi.org/10.1099/mic.0.2007/012021-0 DOI 10.1101/gad.499409 http://dx.doi.org/10.1101/gad.499409 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4036 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4036 EcoGene EG14288 http://www.ecogene.org/geneInfo.php?eg_id=EG14288 EnsemblBacteria AAC74248 http://www.ensemblgenomes.org/id/AAC74248 EnsemblBacteria AAC74248 http://www.ensemblgenomes.org/id/AAC74248 EnsemblBacteria BAE76385 http://www.ensemblgenomes.org/id/BAE76385 EnsemblBacteria BAE76385 http://www.ensemblgenomes.org/id/BAE76385 EnsemblBacteria BAE76385 http://www.ensemblgenomes.org/id/BAE76385 EnsemblBacteria b1164 http://www.ensemblgenomes.org/id/b1164 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0071229 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071229 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 945885 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945885 HOGENOM HOG000267903 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267903&db=HOGENOM6 IntAct P75991 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75991* InterPro IPR024753 http://www.ebi.ac.uk/interpro/entry/IPR024753 KEGG_Gene ecj:JW1151 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1151 KEGG_Gene eco:b1164 http://www.genome.jp/dbget-bin/www_bget?eco:b1164 OMA KAALPTQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KAALPTQ PSORT swissprot:YCGZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCGZ_ECOLI PSORT-B swissprot:YCGZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCGZ_ECOLI PSORT2 swissprot:YCGZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCGZ_ECOLI Pfam PF10798 http://pfam.xfam.org/family/PF10798 Phobius swissprot:YCGZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCGZ_ECOLI ProteinModelPortal P75991 http://www.proteinmodelportal.org/query/uniprot/P75991 PubMed 14527658 http://www.ncbi.nlm.nih.gov/pubmed/14527658 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18174134 http://www.ncbi.nlm.nih.gov/pubmed/18174134 PubMed 19172264 http://www.ncbi.nlm.nih.gov/pubmed/19172264 PubMed 19240136 http://www.ncbi.nlm.nih.gov/pubmed/19240136 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415682 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415682 RefSeq WP_000554140 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000554140 STRING 511145.b1164 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1164&targetmode=cogs UniProtKB YCGZ_ECOLI http://www.uniprot.org/uniprot/YCGZ_ECOLI UniProtKB-AC P75991 http://www.uniprot.org/uniprot/P75991 charge swissprot:YCGZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCGZ_ECOLI eggNOG ENOG4105WKE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105WKE eggNOG ENOG41123BX http://eggnogapi.embl.de/nog_data/html/tree/ENOG41123BX epestfind swissprot:YCGZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCGZ_ECOLI garnier swissprot:YCGZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCGZ_ECOLI helixturnhelix swissprot:YCGZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCGZ_ECOLI hmoment swissprot:YCGZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCGZ_ECOLI iep swissprot:YCGZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCGZ_ECOLI inforesidue swissprot:YCGZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCGZ_ECOLI octanol swissprot:YCGZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCGZ_ECOLI pepcoil swissprot:YCGZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCGZ_ECOLI pepdigest swissprot:YCGZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCGZ_ECOLI pepinfo swissprot:YCGZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCGZ_ECOLI pepnet swissprot:YCGZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCGZ_ECOLI pepstats swissprot:YCGZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCGZ_ECOLI pepwheel swissprot:YCGZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCGZ_ECOLI pepwindow swissprot:YCGZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCGZ_ECOLI sigcleave swissprot:YCGZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCGZ_ECOLI ## Database ID URL or Descriptions # BioGrid 4260687 256 # EcoGene EG12689 yceK # GO_component GO:0031246 intrinsic component of periplasmic side of cell outer membrane; IMP:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0006950 response to stress # InterPro IPR010780 DUF1375 # Organism YCEK_ECOLI Escherichia coli (strain K12) # PATRIC 32117339 VBIEscCol129921_1092 # PIR G64847 G64847 # Pfam PF07119 DUF1375 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCEK_ECOLI Uncharacterized protein YceK # RefSeq NP_415568 NC_000913.3 # RefSeq WP_001237205 NZ_LN832404.1 # SIMILARITY To E.coli YidQ. {ECO 0000305}. # eggNOG COG5645 LUCA # eggNOG ENOG4105NAC Bacteria BLAST swissprot:YCEK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCEK_ECOLI BioCyc ECOL316407:JW5151-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5151-MONOMER BioCyc EcoCyc:EG12689-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12689-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1111/j.1365-2958.1993.tb01959.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb01959.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X59939 http://www.ebi.ac.uk/ena/data/view/X59939 EMBL X64197 http://www.ebi.ac.uk/ena/data/view/X64197 EchoBASE EB2552 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2552 EcoGene EG12689 http://www.ecogene.org/geneInfo.php?eg_id=EG12689 EnsemblBacteria AAC74134 http://www.ensemblgenomes.org/id/AAC74134 EnsemblBacteria AAC74134 http://www.ensemblgenomes.org/id/AAC74134 EnsemblBacteria BAA35849 http://www.ensemblgenomes.org/id/BAA35849 EnsemblBacteria BAA35849 http://www.ensemblgenomes.org/id/BAA35849 EnsemblBacteria BAA35849 http://www.ensemblgenomes.org/id/BAA35849 EnsemblBacteria b1050 http://www.ensemblgenomes.org/id/b1050 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0031246 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031246 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 945613 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945613 HOGENOM HOG000126348 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126348&db=HOGENOM6 InParanoid P0AB31 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AB31 InterPro IPR010780 http://www.ebi.ac.uk/interpro/entry/IPR010780 KEGG_Gene ecj:JW5151 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5151 KEGG_Gene eco:b1050 http://www.genome.jp/dbget-bin/www_bget?eco:b1050 OMA VDAHHGP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VDAHHGP PSORT swissprot:YCEK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCEK_ECOLI PSORT-B swissprot:YCEK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCEK_ECOLI PSORT2 swissprot:YCEK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCEK_ECOLI Pfam PF07119 http://pfam.xfam.org/family/PF07119 Phobius swissprot:YCEK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCEK_ECOLI ProteinModelPortal P0AB31 http://www.proteinmodelportal.org/query/uniprot/P0AB31 PubMed 1537791 http://www.ncbi.nlm.nih.gov/pubmed/1537791 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 7934824 http://www.ncbi.nlm.nih.gov/pubmed/7934824 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415568 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415568 RefSeq WP_001237205 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001237205 STRING 511145.b1050 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1050&targetmode=cogs UniProtKB YCEK_ECOLI http://www.uniprot.org/uniprot/YCEK_ECOLI UniProtKB-AC P0AB31 http://www.uniprot.org/uniprot/P0AB31 charge swissprot:YCEK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCEK_ECOLI eggNOG COG5645 http://eggnogapi.embl.de/nog_data/html/tree/COG5645 eggNOG ENOG4105NAC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105NAC epestfind swissprot:YCEK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCEK_ECOLI garnier swissprot:YCEK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCEK_ECOLI helixturnhelix swissprot:YCEK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCEK_ECOLI hmoment swissprot:YCEK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCEK_ECOLI iep swissprot:YCEK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCEK_ECOLI inforesidue swissprot:YCEK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCEK_ECOLI octanol swissprot:YCEK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCEK_ECOLI pepcoil swissprot:YCEK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCEK_ECOLI pepdigest swissprot:YCEK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCEK_ECOLI pepinfo swissprot:YCEK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCEK_ECOLI pepnet swissprot:YCEK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCEK_ECOLI pepstats swissprot:YCEK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCEK_ECOLI pepwheel swissprot:YCEK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCEK_ECOLI pepwindow swissprot:YCEK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCEK_ECOLI sigcleave swissprot:YCEK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCEK_ECOLI ## Database ID URL or Descriptions # BioGrid 4259441 14 # EcoGene EG13713 ycbU # FUNCTION YCBU_ECOLI Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. {ECO 0000269|PubMed 20345943}. # GO_component GO:0009289 pilus; IEA:InterPro. # GO_process GO:0043709 cell adhesion involved in single-species biofilm formation; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0007155 cell adhesion # Gene3D 2.60.40.1090 -; 1. # INDUCTION Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression. {ECO:0000269|PubMed 20345943}. # InterPro IPR000259 Adhesion_dom_fimbrial # InterPro IPR008966 Adhesion_dom # MISCELLANEOUS The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed. {ECO:0000305|PubMed 20345943}. # Organism YCBU_ECOLI Escherichia coli (strain K12) # PATRIC 32117103 VBIEscCol129921_0976 # PIR E64834 E64834 # Pfam PF00419 Fimbrial # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCBU_ECOLI Uncharacterized fimbrial-like protein YcbU # RefSeq NP_415462 NC_000913.3 # SUPFAM SSF49401 SSF49401 # eggNOG COG3539 LUCA # eggNOG ENOG4105Q7J Bacteria BLAST swissprot:YCBU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCBU_ECOLI BioCyc ECOL316407:JW0925-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0925-MONOMER BioCyc EcoCyc:G6484-MONOMER http://biocyc.org/getid?id=EcoCyc:G6484-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1462-2920.2010.02202.x http://dx.doi.org/10.1111/j.1462-2920.2010.02202.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3477 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3477 EcoGene EG13713 http://www.ecogene.org/geneInfo.php?eg_id=EG13713 EnsemblBacteria AAC74028 http://www.ensemblgenomes.org/id/AAC74028 EnsemblBacteria AAC74028 http://www.ensemblgenomes.org/id/AAC74028 EnsemblBacteria BAA35697 http://www.ensemblgenomes.org/id/BAA35697 EnsemblBacteria BAA35697 http://www.ensemblgenomes.org/id/BAA35697 EnsemblBacteria BAA35697 http://www.ensemblgenomes.org/id/BAA35697 EnsemblBacteria b0942 http://www.ensemblgenomes.org/id/b0942 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009289 GO_process GO:0043709 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043709 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 Gene3D 2.60.40.1090 http://www.cathdb.info/version/latest/superfamily/2.60.40.1090 GeneID 945561 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945561 HOGENOM HOG000260127 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260127&db=HOGENOM6 InParanoid P75859 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75859 InterPro IPR000259 http://www.ebi.ac.uk/interpro/entry/IPR000259 InterPro IPR008966 http://www.ebi.ac.uk/interpro/entry/IPR008966 KEGG_Gene ecj:JW0925 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0925 KEGG_Gene eco:b0942 http://www.genome.jp/dbget-bin/www_bget?eco:b0942 OMA MATWIAV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MATWIAV PSORT swissprot:YCBU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCBU_ECOLI PSORT-B swissprot:YCBU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCBU_ECOLI PSORT2 swissprot:YCBU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCBU_ECOLI Pfam PF00419 http://pfam.xfam.org/family/PF00419 Phobius swissprot:YCBU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCBU_ECOLI PhylomeDB P75859 http://phylomedb.org/?seqid=P75859 ProteinModelPortal P75859 http://www.proteinmodelportal.org/query/uniprot/P75859 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20345943 http://www.ncbi.nlm.nih.gov/pubmed/20345943 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415462 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415462 SMR P75859 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75859 STRING 511145.b0942 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0942&targetmode=cogs SUPFAM SSF49401 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49401 UniProtKB YCBU_ECOLI http://www.uniprot.org/uniprot/YCBU_ECOLI UniProtKB-AC P75859 http://www.uniprot.org/uniprot/P75859 charge swissprot:YCBU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCBU_ECOLI eggNOG COG3539 http://eggnogapi.embl.de/nog_data/html/tree/COG3539 eggNOG ENOG4105Q7J http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105Q7J epestfind swissprot:YCBU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCBU_ECOLI garnier swissprot:YCBU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCBU_ECOLI helixturnhelix swissprot:YCBU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCBU_ECOLI hmoment swissprot:YCBU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCBU_ECOLI iep swissprot:YCBU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCBU_ECOLI inforesidue swissprot:YCBU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCBU_ECOLI octanol swissprot:YCBU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCBU_ECOLI pepcoil swissprot:YCBU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCBU_ECOLI pepdigest swissprot:YCBU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCBU_ECOLI pepinfo swissprot:YCBU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCBU_ECOLI pepnet swissprot:YCBU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCBU_ECOLI pepstats swissprot:YCBU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCBU_ECOLI pepwheel swissprot:YCBU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCBU_ECOLI pepwindow swissprot:YCBU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCBU_ECOLI sigcleave swissprot:YCBU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCBU_ECOLI ## Database ID URL or Descriptions # BioGrid 4262625 408 # COFACTOR ENGB_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_00321}; # EcoGene EG11203 engB # FUNCTION ENGB_ECOLI Necessary for normal cell division and for the maintenance of normal septation. Depletion of this protein leads to a severe reduction in growth rate and to extensive filamentation, with a block beyond the stage of segregation. Essential for bacteria survival. {ECO 0000255|HAMAP-Rule MF_00321, ECO 0000269|PubMed 10572302}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0003924 GTPase activity; IBA:GO_Central. # GO_function GO:0005525 GTP binding; IDA:EcoCyc. # GO_process GO:0090529 cell septum assembly; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003924 GTPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0022607 cellular component assembly # Gene3D 3.40.50.300 -; 1. # HAMAP MF_00321 GTPase_EngB # InterPro IPR006073 GTP_binding_domain # InterPro IPR019987 GTP-bd_ribosome_bio_YsxC # InterPro IPR027417 P-loop_NTPase # InterPro IPR030393 G_ENGB_dom # Organism ENGB_ECOLI Escherichia coli (strain K12) # PATRIC 32123229 VBIEscCol129921_3975 # PDB 1PUI X-ray; 2.00 A; A/B=1-210 # PIR S40810 S40810 # PROSITE PS51706 G_ENGB # Pfam PF01926 MMR_HSR1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Probable GTP-binding protein EngB {ECO:0000255|HAMAP-Rule MF_00321} # RefSeq NP_418301 NC_000913.3 # RefSeq WP_000183349 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA24403.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAB02999.1; Type=Erroneous initiation; Evidence={ECO 0000305}; Sequence=BAE77444.1; Type=Erroneous initiation; Evidence={ECO:0000305}; # SIMILARITY Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. EngB GTPase family. {ECO:0000255|HAMAP- Rule MF_00321}. # SIMILARITY Contains 1 EngB-type G (guanine nucleotide-binding) domain. {ECO:0000255|HAMAP-Rule MF_00321}. # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR03598 GTPase_YsxC # eggNOG COG0218 LUCA # eggNOG ENOG4105WHM Bacteria BLAST swissprot:ENGB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ENGB_ECOLI BioCyc ECOL316407:JW5930-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5930-MONOMER BioCyc EcoCyc:EG11203-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11203-MONOMER COG COG0218 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0218 DIP DIP-48178N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48178N DOI 10.1016/S0300-9084(99)00207-2 http://dx.doi.org/10.1016/S0300-9084(99)00207-2 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01663 http://www.ebi.ac.uk/ena/data/view/J01663 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1188 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1188 EcoGene EG11203 http://www.ecogene.org/geneInfo.php?eg_id=EG11203 EnsemblBacteria AAC76862 http://www.ensemblgenomes.org/id/AAC76862 EnsemblBacteria AAC76862 http://www.ensemblgenomes.org/id/AAC76862 EnsemblBacteria BAE77444 http://www.ensemblgenomes.org/id/BAE77444 EnsemblBacteria BAE77444 http://www.ensemblgenomes.org/id/BAE77444 EnsemblBacteria BAE77444 http://www.ensemblgenomes.org/id/BAE77444 EnsemblBacteria b3865 http://www.ensemblgenomes.org/id/b3865 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_process GO:0090529 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090529 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948358 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948358 HAMAP MF_00321 http://hamap.expasy.org/unirule/MF_00321 HOGENOM HOG000009832 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009832&db=HOGENOM6 InParanoid P0A6P7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6P7 InterPro IPR006073 http://www.ebi.ac.uk/interpro/entry/IPR006073 InterPro IPR019987 http://www.ebi.ac.uk/interpro/entry/IPR019987 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR030393 http://www.ebi.ac.uk/interpro/entry/IPR030393 KEGG_Gene ecj:JW5930 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5930 KEGG_Gene eco:b3865 http://www.genome.jp/dbget-bin/www_bget?eco:b3865 KEGG_Orthology KO:K03978 http://www.genome.jp/dbget-bin/www_bget?KO:K03978 OMA KQHWQRH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KQHWQRH PDB 1PUI http://www.ebi.ac.uk/pdbe-srv/view/entry/1PUI PDBsum 1PUI http://www.ebi.ac.uk/pdbsum/1PUI PROSITE PS51706 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51706 PSORT swissprot:ENGB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ENGB_ECOLI PSORT-B swissprot:ENGB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ENGB_ECOLI PSORT2 swissprot:ENGB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ENGB_ECOLI Pfam PF01926 http://pfam.xfam.org/family/PF01926 Phobius swissprot:ENGB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ENGB_ECOLI PhylomeDB P0A6P7 http://phylomedb.org/?seqid=P0A6P7 ProteinModelPortal P0A6P7 http://www.proteinmodelportal.org/query/uniprot/P0A6P7 PubMed 10572302 http://www.ncbi.nlm.nih.gov/pubmed/10572302 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6183253 http://www.ncbi.nlm.nih.gov/pubmed/6183253 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418301 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418301 RefSeq WP_000183349 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000183349 SMR P0A6P7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6P7 STRING 511145.b3865 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3865&targetmode=cogs STRING COG0218 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0218&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR03598 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03598 UniProtKB ENGB_ECOLI http://www.uniprot.org/uniprot/ENGB_ECOLI UniProtKB-AC P0A6P7 http://www.uniprot.org/uniprot/P0A6P7 charge swissprot:ENGB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ENGB_ECOLI eggNOG COG0218 http://eggnogapi.embl.de/nog_data/html/tree/COG0218 eggNOG ENOG4105WHM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105WHM epestfind swissprot:ENGB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ENGB_ECOLI garnier swissprot:ENGB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ENGB_ECOLI helixturnhelix swissprot:ENGB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ENGB_ECOLI hmoment swissprot:ENGB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ENGB_ECOLI iep swissprot:ENGB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ENGB_ECOLI inforesidue swissprot:ENGB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ENGB_ECOLI octanol swissprot:ENGB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ENGB_ECOLI pepcoil swissprot:ENGB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ENGB_ECOLI pepdigest swissprot:ENGB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ENGB_ECOLI pepinfo swissprot:ENGB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ENGB_ECOLI pepnet swissprot:ENGB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ENGB_ECOLI pepstats swissprot:ENGB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ENGB_ECOLI pepwheel swissprot:ENGB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ENGB_ECOLI pepwindow swissprot:ENGB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ENGB_ECOLI sigcleave swissprot:ENGB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ENGB_ECOLI ## Database ID URL or Descriptions # AltName PCA reductase {ECO:0000255|HAMAP-Rule MF_01925} # BioGrid 4263533 16 # CATALYTIC ACTIVITY P5CR_ECOLI L-proline + NAD(P)(+) = 1-pyrroline-5- carboxylate + NAD(P)H. {ECO 0000255|HAMAP-Rule MF_01925, ECO 0000269|PubMed 12133, ECO 0000269|PubMed 6296787}. # ENZYME REGULATION Inhibited by p-chloromercuribenzoate. {ECO:0000269|PubMed 12133}. # EcoGene EG10769 proC # FUNCTION P5CR_ECOLI Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. Does not catalyze the reverse reaction. {ECO 0000255|HAMAP-Rule MF_01925, ECO 0000269|PubMed 12133, ECO 0000269|PubMed 6296787}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004735 pyrroline-5-carboxylate reductase activity; IDA:EcoCyc. # GO_function GO:0050661 NADP binding; IDA:EcoCyc. # GO_process GO:0055129 L-proline biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 1.10.3730.10 -; 1. # Gene3D 3.40.50.720 -; 1. # HAMAP MF_01925 P5C_reductase # IntAct P0A9L8 4 # InterPro IPR000304 Pyrroline-COOH_reductase # InterPro IPR008927 6-PGluconate_DH_C-like # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR028939 ProC_N # InterPro IPR029036 P5CR_dimer # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00330 Arginine and proline metabolism # MISCELLANEOUS Can use either NADPH or NADH, but the activity observed with NADPH is severalfold greater. {ECO:0000305|PubMed 12133}. # Organism P5CR_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11645 PTHR11645 # PATHWAY P5CR_ECOLI Amino-acid biosynthesis; L-proline biosynthesis; L- proline from L-glutamate 5-semialdehyde step 1/1. {ECO 0000255|HAMAP-Rule MF_01925, ECO 0000269|PubMed 12133, ECO 0000269|PubMed 6296787}. # PATRIC 32115913 VBIEscCol129921_0398 # PIR A00385 RDECC # PIRSF PIRSF000193 Pyrrol-5-carb_rd # PROSITE PS00521 P5CR # Pfam PF03807 F420_oxidored # Pfam PF14748 P5CR_dimer # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Pyrroline-5-carboxylate reductase {ECO:0000255|HAMAP-Rule MF_01925} # RefSeq NP_414920 NC_000913.3 # RefSeq WP_001295331 NZ_LN832404.1 # SIMILARITY Belongs to the pyrroline-5-carboxylate reductase family. {ECO:0000255|HAMAP-Rule MF_01925}. # SUBCELLULAR LOCATION P5CR_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_01925, ECO 0000269|PubMed 6296787}. # SUPFAM SSF48179 SSF48179 # SUPFAM SSF51735 SSF51735 # TIGRFAMs TIGR00112 proC # UniPathway UPA00098 UER00361 # eggNOG COG0345 LUCA # eggNOG ENOG4105II7 Bacteria BLAST swissprot:P5CR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:P5CR_ECOLI BioCyc ECOL316407:JW0377-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0377-MONOMER BioCyc EcoCyc:PYRROLINECARBREDUCT-MONOMER http://biocyc.org/getid?id=EcoCyc:PYRROLINECARBREDUCT-MONOMER BioCyc MetaCyc:PYRROLINECARBREDUCT-MONOMER http://biocyc.org/getid?id=MetaCyc:PYRROLINECARBREDUCT-MONOMER COG COG0345 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0345 DIP DIP-47863N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47863N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/10.23.7701 http://dx.doi.org/10.1093/nar/10.23.7701 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.5.1.2 {ECO:0000255|HAMAP-Rule:MF_01925} http://www.genome.jp/dbget-bin/www_bget?EC:1.5.1.2 {ECO:0000255|HAMAP-Rule:MF_01925} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01665 http://www.ebi.ac.uk/ena/data/view/J01665 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 ENZYME 1.5.1.2 {ECO:0000255|HAMAP-Rule:MF_01925} http://enzyme.expasy.org/EC/1.5.1.2 {ECO:0000255|HAMAP-Rule:MF_01925} EchoBASE EB0762 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0762 EcoGene EG10769 http://www.ecogene.org/geneInfo.php?eg_id=EG10769 EnsemblBacteria AAC73489 http://www.ensemblgenomes.org/id/AAC73489 EnsemblBacteria AAC73489 http://www.ensemblgenomes.org/id/AAC73489 EnsemblBacteria BAE76167 http://www.ensemblgenomes.org/id/BAE76167 EnsemblBacteria BAE76167 http://www.ensemblgenomes.org/id/BAE76167 EnsemblBacteria BAE76167 http://www.ensemblgenomes.org/id/BAE76167 EnsemblBacteria b0386 http://www.ensemblgenomes.org/id/b0386 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004735 GO_function GO:0050661 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050661 GO_process GO:0055129 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055129 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 1.10.3730.10 http://www.cathdb.info/version/latest/superfamily/1.10.3730.10 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 945034 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945034 HAMAP MF_01925 http://hamap.expasy.org/unirule/MF_01925 HOGENOM HOG000230247 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230247&db=HOGENOM6 InParanoid P0A9L8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9L8 IntAct P0A9L8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9L8* IntEnz 1.5.1.2 {ECO:0000255|HAMAP-Rule:MF_01925} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.5.1.2 {ECO:0000255|HAMAP-Rule:MF_01925} InterPro IPR000304 http://www.ebi.ac.uk/interpro/entry/IPR000304 InterPro IPR008927 http://www.ebi.ac.uk/interpro/entry/IPR008927 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR028939 http://www.ebi.ac.uk/interpro/entry/IPR028939 InterPro IPR029036 http://www.ebi.ac.uk/interpro/entry/IPR029036 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0377 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0377 KEGG_Gene eco:b0386 http://www.genome.jp/dbget-bin/www_bget?eco:b0386 KEGG_Orthology KO:K00286 http://www.genome.jp/dbget-bin/www_bget?KO:K00286 KEGG_Pathway ko00330 http://www.genome.jp/kegg-bin/show_pathway?ko00330 KEGG_Reaction rn:R01248 http://www.genome.jp/dbget-bin/www_bget?rn:R01248 KEGG_Reaction rn:R01251 http://www.genome.jp/dbget-bin/www_bget?rn:R01251 KEGG_Reaction rn:R03291 http://www.genome.jp/dbget-bin/www_bget?rn:R03291 KEGG_Reaction rn:R03293 http://www.genome.jp/dbget-bin/www_bget?rn:R03293 OMA LFIEAMA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LFIEAMA PANTHER PTHR11645 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11645 PROSITE PS00521 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00521 PSORT swissprot:P5CR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:P5CR_ECOLI PSORT-B swissprot:P5CR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:P5CR_ECOLI PSORT2 swissprot:P5CR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:P5CR_ECOLI Pfam PF03807 http://pfam.xfam.org/family/PF03807 Pfam PF14748 http://pfam.xfam.org/family/PF14748 Phobius swissprot:P5CR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:P5CR_ECOLI PhylomeDB P0A9L8 http://phylomedb.org/?seqid=P0A9L8 ProteinModelPortal P0A9L8 http://www.proteinmodelportal.org/query/uniprot/P0A9L8 PubMed 12133 http://www.ncbi.nlm.nih.gov/pubmed/12133 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6296787 http://www.ncbi.nlm.nih.gov/pubmed/6296787 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414920 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414920 RefSeq WP_001295331 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295331 SMR P0A9L8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9L8 STRING 511145.b0386 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0386&targetmode=cogs STRING COG0345 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0345&targetmode=cogs SUPFAM SSF48179 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48179 SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 TIGRFAMs TIGR00112 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00112 UniProtKB P5CR_ECOLI http://www.uniprot.org/uniprot/P5CR_ECOLI UniProtKB-AC P0A9L8 http://www.uniprot.org/uniprot/P0A9L8 charge swissprot:P5CR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:P5CR_ECOLI eggNOG COG0345 http://eggnogapi.embl.de/nog_data/html/tree/COG0345 eggNOG ENOG4105II7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105II7 epestfind swissprot:P5CR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:P5CR_ECOLI garnier swissprot:P5CR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:P5CR_ECOLI helixturnhelix swissprot:P5CR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:P5CR_ECOLI hmoment swissprot:P5CR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:P5CR_ECOLI iep swissprot:P5CR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:P5CR_ECOLI inforesidue swissprot:P5CR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:P5CR_ECOLI octanol swissprot:P5CR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:P5CR_ECOLI pepcoil swissprot:P5CR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:P5CR_ECOLI pepdigest swissprot:P5CR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:P5CR_ECOLI pepinfo swissprot:P5CR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:P5CR_ECOLI pepnet swissprot:P5CR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:P5CR_ECOLI pepstats swissprot:P5CR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:P5CR_ECOLI pepwheel swissprot:P5CR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:P5CR_ECOLI pepwindow swissprot:P5CR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:P5CR_ECOLI sigcleave swissprot:P5CR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:P5CR_ECOLI ## Database ID URL or Descriptions # BioGrid 4262957 4 # EcoGene EG13408 slyA # FUNCTION SLYA_ECOLI Transcription regulator that can specifically activate or repress expression of target genes. Activates expression of genes such as molecular chaperones (groL, groS, dnaK, grpE, and cbpA), proteins involved in acid resistance (hdeA, hdeB, and gadA), the starvation lipoprotein slp, virulence protein hlyE/clyA. Represses expression of genes involved in the histidine biosynthetic pathway such as hisA, hisB, hisD, hisF and hisG. Required for the activation of virulence genes. {ECO 0000255|HAMAP-Rule MF_01819, ECO 0000269|PubMed 11053378, ECO 0000269|PubMed 12057949, ECO 0000269|PubMed 8861216}. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IMP:EcoliWiki. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-HAMAP. # GO_process GO:0009405 pathogenesis; IEA:UniProtKB-KW. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # HAMAP MF_01819 HTH_type_SlyA # InterPro IPR000835 HTH_MarR-typ # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR023071 Tscrpt_reg_SlyA # InterPro IPR023187 Tscrpt_reg_MarR-type_CS # KEGG_Brite ko03000 Transcription factors # Organism SLYA_ECOLI Escherichia coli (strain K12) # PATRIC 32118586 VBIEscCol129921_1713 # PIR S70929 S70929 # PRINTS PR00598 HTHMARR # PROSITE PS01117 HTH_MARR_1 # PROSITE PS50995 HTH_MARR_2 # Pfam PF01047 MarR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Transcriptional regulator SlyA {ECO:0000255|HAMAP-Rule MF_01819} # RefSeq NP_416159 NC_000913.3 # RefSeq WP_001296943 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA09442.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA72078.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the SlyA family. {ECO:0000255|HAMAP- Rule MF_01819}. # SIMILARITY Contains 1 HTH marR-type DNA-binding domain. {ECO:0000255|HAMAP-Rule MF_01819}. # SMART SM00347 HTH_MARR # SUBUNIT Homodimer. {ECO:0000255|HAMAP-Rule MF_01819}. # SUPFAM SSF46785 SSF46785 # eggNOG COG1846 LUCA # eggNOG ENOG4108US0 Bacteria BLAST swissprot:SLYA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SLYA_ECOLI BioCyc ECOL316407:JW5267-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5267-MONOMER BioCyc EcoCyc:G6882-MONOMER http://biocyc.org/getid?id=EcoCyc:G6882-MONOMER COG COG1846 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1846 DOI 10.1007/BF00290573 http://dx.doi.org/10.1007/BF00290573 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1999.01196.x http://dx.doi.org/10.1046/j.1365-2958.1999.01196.x DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1111/j.1365-2958.1996.tb02500.x http://dx.doi.org/10.1111/j.1365-2958.1996.tb02500.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.22.6347-6357.2000 http://dx.doi.org/10.1128/JB.182.22.6347-6357.2000 DOI 10.1128/JB.184.13.3549-3559.2002 http://dx.doi.org/10.1128/JB.184.13.3549-3559.2002 EMBL AJ010965 http://www.ebi.ac.uk/ena/data/view/AJ010965 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL Y11194 http://www.ebi.ac.uk/ena/data/view/Y11194 EchoBASE EB3184 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3184 EcoGene EG13408 http://www.ecogene.org/geneInfo.php?eg_id=EG13408 EnsemblBacteria AAC74714 http://www.ensemblgenomes.org/id/AAC74714 EnsemblBacteria AAC74714 http://www.ensemblgenomes.org/id/AAC74714 EnsemblBacteria BAA15403 http://www.ensemblgenomes.org/id/BAA15403 EnsemblBacteria BAA15403 http://www.ensemblgenomes.org/id/BAA15403 EnsemblBacteria BAA15403 http://www.ensemblgenomes.org/id/BAA15403 EnsemblBacteria b1642 http://www.ensemblgenomes.org/id/b1642 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0009405 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009405 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 946167 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946167 HAMAP MF_01819 http://hamap.expasy.org/unirule/MF_01819 HOGENOM HOG000221454 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000221454&db=HOGENOM6 InParanoid P0A8W2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8W2 InterPro IPR000835 http://www.ebi.ac.uk/interpro/entry/IPR000835 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR023071 http://www.ebi.ac.uk/interpro/entry/IPR023071 InterPro IPR023187 http://www.ebi.ac.uk/interpro/entry/IPR023187 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW5267 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5267 KEGG_Gene eco:b1642 http://www.genome.jp/dbget-bin/www_bget?eco:b1642 KEGG_Orthology KO:K06075 http://www.genome.jp/dbget-bin/www_bget?KO:K06075 OMA TRHICAH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TRHICAH PRINTS PR00598 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00598 PROSITE PS01117 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01117 PROSITE PS50995 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50995 PSORT swissprot:SLYA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SLYA_ECOLI PSORT-B swissprot:SLYA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SLYA_ECOLI PSORT2 swissprot:SLYA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SLYA_ECOLI Pfam PF01047 http://pfam.xfam.org/family/PF01047 Phobius swissprot:SLYA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SLYA_ECOLI PhylomeDB P0A8W2 http://phylomedb.org/?seqid=P0A8W2 ProteinModelPortal P0A8W2 http://www.proteinmodelportal.org/query/uniprot/P0A8W2 PubMed 10027972 http://www.ncbi.nlm.nih.gov/pubmed/10027972 PubMed 11053378 http://www.ncbi.nlm.nih.gov/pubmed/11053378 PubMed 12057949 http://www.ncbi.nlm.nih.gov/pubmed/12057949 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8544813 http://www.ncbi.nlm.nih.gov/pubmed/8544813 PubMed 8861216 http://www.ncbi.nlm.nih.gov/pubmed/8861216 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416159 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416159 RefSeq WP_001296943 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001296943 SMART SM00347 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00347 SMR P0A8W2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8W2 STRING 511145.b1642 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1642&targetmode=cogs STRING COG1846 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1846&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB SLYA_ECOLI http://www.uniprot.org/uniprot/SLYA_ECOLI UniProtKB-AC P0A8W2 http://www.uniprot.org/uniprot/P0A8W2 charge swissprot:SLYA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SLYA_ECOLI eggNOG COG1846 http://eggnogapi.embl.de/nog_data/html/tree/COG1846 eggNOG ENOG4108US0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108US0 epestfind swissprot:SLYA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SLYA_ECOLI garnier swissprot:SLYA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SLYA_ECOLI helixturnhelix swissprot:SLYA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SLYA_ECOLI hmoment swissprot:SLYA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SLYA_ECOLI iep swissprot:SLYA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SLYA_ECOLI inforesidue swissprot:SLYA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SLYA_ECOLI octanol swissprot:SLYA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SLYA_ECOLI pepcoil swissprot:SLYA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SLYA_ECOLI pepdigest swissprot:SLYA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SLYA_ECOLI pepinfo swissprot:SLYA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SLYA_ECOLI pepnet swissprot:SLYA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SLYA_ECOLI pepstats swissprot:SLYA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SLYA_ECOLI pepwheel swissprot:SLYA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SLYA_ECOLI pepwindow swissprot:SLYA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SLYA_ECOLI sigcleave swissprot:SLYA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SLYA_ECOLI ## Database ID URL or Descriptions # AltName GLNA_ECOLI Glutamate--ammonia ligase # BioGrid 4262630 12 # CATALYTIC ACTIVITY GLNA_ECOLI ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine. # ENZYME REGULATION GLNA_ECOLI The activity of this enzyme is controlled by adenylation under conditions of abundant glutamine. The fully adenylated enzyme complex is inactive. # EcoGene EG10383 glnA # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0004356 glutamate-ammonia ligase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0006542 glutamine biosynthetic process; IEA:InterPro. # GO_process GO:0009399 nitrogen fixation; IEA:InterPro. # GO_process GO:0019676 ammonia assimilation cycle; IDA:EcoCyc. # GO_process GO:0019740 nitrogen utilization; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0071941 nitrogen cycle metabolic process # Gene3D 3.10.20.70 -; 1. # Gene3D 3.30.590.10 -; 1. # INTERACTION GLNA_ECOLI Self; NbExp=2; IntAct=EBI-909063, EBI-909063; # IntAct P0A9C5 10 # InterPro IPR001637 Gln_synth_I_adenylation_site # InterPro IPR004809 Gln_synth_I # InterPro IPR008146 Gln_synth_cat_dom # InterPro IPR008147 Gln_synt_b-grasp # InterPro IPR014746 Gln_synth/guanido_kin_cat_dom # InterPro IPR027302 Gln_synth_N_conserv_site # InterPro IPR027303 Gln_synth_gly_rich_site # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00250 Alanine, aspartate and glutamate metabolism # KEGG_Pathway ko00330 Arginine and proline metabolism # KEGG_Pathway ko00630 Glyoxylate and dicarboxylate metabolism # KEGG_Pathway ko00910 Nitrogen metabolism # KEGG_Pathway ko02020 Two-component system # KEGG_Pathway ko04724 Glutamatergic synapse # KEGG_Pathway ko04727 GABAergic synapse # Organism GLNA_ECOLI Escherichia coli (strain K12) # PATRIC 32123243 VBIEscCol129921_3982 # PIR S40815 AJECQ # PROSITE PS00180 GLNA_1 # PROSITE PS00181 GLNA_ATP # PROSITE PS00182 GLNA_ADENYLATION # Pfam PF00120 Gln-synt_C # Pfam PF03951 Gln-synt_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLNA_ECOLI Glutamine synthetase # RefSeq NP_418306 NC_000913.3 # RefSeq WP_001271717 NZ_LN832404.1 # SIMILARITY Belongs to the glutamine synthetase family. {ECO 0000305}. # SMART SM01230 Gln-synt_C # SUBCELLULAR LOCATION GLNA_ECOLI Cytoplasm. # SUBUNIT GLNA_ECOLI Oligomer of 12 subunits arranged in the form of two hexagons. # SUPFAM SSF54368 SSF54368 # TIGRFAMs TIGR00653 GlnA # eggNOG COG0174 LUCA # eggNOG ENOG4105C5F Bacteria BLAST swissprot:GLNA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLNA_ECOLI BioCyc ECOL316407:JW3841-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3841-MONOMER BioCyc EcoCyc:GLUTAMINESYN-MONOMER http://biocyc.org/getid?id=EcoCyc:GLUTAMINESYN-MONOMER BioCyc MetaCyc:GLUTAMINESYN-MONOMER http://biocyc.org/getid?id=MetaCyc:GLUTAMINESYN-MONOMER COG COG0174 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0174 DIP DIP-9777N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9777N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1007/BF00330342 http://dx.doi.org/10.1007/BF00330342 DOI 10.1016/0378-1119(85)90261-6 http://dx.doi.org/10.1016/0378-1119(85)90261-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.82.7.1979 http://dx.doi.org/10.1073/pnas.82.7.1979 DOI 10.1093/nar/15.6.2757 http://dx.doi.org/10.1093/nar/15.6.2757 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.3.1.2 http://www.genome.jp/dbget-bin/www_bget?EC:6.3.1.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01618 http://www.ebi.ac.uk/ena/data/view/J01618 EMBL K02176 http://www.ebi.ac.uk/ena/data/view/K02176 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL M10421 http://www.ebi.ac.uk/ena/data/view/M10421 EMBL M13746 http://www.ebi.ac.uk/ena/data/view/M13746 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X05173 http://www.ebi.ac.uk/ena/data/view/X05173 ENZYME 6.3.1.2 http://enzyme.expasy.org/EC/6.3.1.2 EchoBASE EB0378 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0378 EcoGene EG10383 http://www.ecogene.org/geneInfo.php?eg_id=EG10383 EnsemblBacteria AAC76867 http://www.ensemblgenomes.org/id/AAC76867 EnsemblBacteria AAC76867 http://www.ensemblgenomes.org/id/AAC76867 EnsemblBacteria BAE77439 http://www.ensemblgenomes.org/id/BAE77439 EnsemblBacteria BAE77439 http://www.ensemblgenomes.org/id/BAE77439 EnsemblBacteria BAE77439 http://www.ensemblgenomes.org/id/BAE77439 EnsemblBacteria b3870 http://www.ensemblgenomes.org/id/b3870 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0004356 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004356 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006542 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006542 GO_process GO:0009399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009399 GO_process GO:0019676 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019676 GO_process GO:0019740 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019740 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0071941 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071941 Gene3D 3.10.20.70 http://www.cathdb.info/version/latest/superfamily/3.10.20.70 Gene3D 3.30.590.10 http://www.cathdb.info/version/latest/superfamily/3.30.590.10 GeneID 948370 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948370 HOGENOM HOG000005157 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000005157&db=HOGENOM6 InParanoid P0A9C5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9C5 IntAct P0A9C5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9C5* IntEnz 6.3.1.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.1.2 InterPro IPR001637 http://www.ebi.ac.uk/interpro/entry/IPR001637 InterPro IPR004809 http://www.ebi.ac.uk/interpro/entry/IPR004809 InterPro IPR008146 http://www.ebi.ac.uk/interpro/entry/IPR008146 InterPro IPR008147 http://www.ebi.ac.uk/interpro/entry/IPR008147 InterPro IPR014746 http://www.ebi.ac.uk/interpro/entry/IPR014746 InterPro IPR027302 http://www.ebi.ac.uk/interpro/entry/IPR027302 InterPro IPR027303 http://www.ebi.ac.uk/interpro/entry/IPR027303 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3841 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3841 KEGG_Gene eco:b3870 http://www.genome.jp/dbget-bin/www_bget?eco:b3870 KEGG_Orthology KO:K01915 http://www.genome.jp/dbget-bin/www_bget?KO:K01915 KEGG_Pathway ko00250 http://www.genome.jp/kegg-bin/show_pathway?ko00250 KEGG_Pathway ko00330 http://www.genome.jp/kegg-bin/show_pathway?ko00330 KEGG_Pathway ko00630 http://www.genome.jp/kegg-bin/show_pathway?ko00630 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 KEGG_Pathway ko04724 http://www.genome.jp/kegg-bin/show_pathway?ko04724 KEGG_Pathway ko04727 http://www.genome.jp/kegg-bin/show_pathway?ko04727 KEGG_Reaction rn:R00253 http://www.genome.jp/dbget-bin/www_bget?rn:R00253 OMA KVLNQVG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KVLNQVG PROSITE PS00180 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00180 PROSITE PS00181 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00181 PROSITE PS00182 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00182 PSORT swissprot:GLNA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLNA_ECOLI PSORT-B swissprot:GLNA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLNA_ECOLI PSORT2 swissprot:GLNA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLNA_ECOLI Pfam PF00120 http://pfam.xfam.org/family/PF00120 Pfam PF03951 http://pfam.xfam.org/family/PF03951 Phobius swissprot:GLNA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLNA_ECOLI PhylomeDB P0A9C5 http://phylomedb.org/?seqid=P0A9C5 ProteinModelPortal P0A9C5 http://www.proteinmodelportal.org/query/uniprot/P0A9C5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2858855 http://www.ncbi.nlm.nih.gov/pubmed/2858855 PubMed 2865194 http://www.ncbi.nlm.nih.gov/pubmed/2865194 PubMed 2874141 http://www.ncbi.nlm.nih.gov/pubmed/2874141 PubMed 2882477 http://www.ncbi.nlm.nih.gov/pubmed/2882477 PubMed 4904088 http://www.ncbi.nlm.nih.gov/pubmed/4904088 PubMed 5543675 http://www.ncbi.nlm.nih.gov/pubmed/5543675 PubMed 6134228 http://www.ncbi.nlm.nih.gov/pubmed/6134228 PubMed 6148334 http://www.ncbi.nlm.nih.gov/pubmed/6148334 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_418306 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418306 RefSeq WP_001271717 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001271717 SMART SM01230 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01230 SMR P0A9C5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9C5 STRING 511145.b3870 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3870&targetmode=cogs STRING COG0174 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0174&targetmode=cogs SUPFAM SSF54368 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54368 SWISS-2DPAGE P0A9C5 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A9C5 TIGRFAMs TIGR00653 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00653 UniProtKB GLNA_ECOLI http://www.uniprot.org/uniprot/GLNA_ECOLI UniProtKB-AC P0A9C5 http://www.uniprot.org/uniprot/P0A9C5 charge swissprot:GLNA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLNA_ECOLI eggNOG COG0174 http://eggnogapi.embl.de/nog_data/html/tree/COG0174 eggNOG ENOG4105C5F http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C5F epestfind swissprot:GLNA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLNA_ECOLI garnier swissprot:GLNA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLNA_ECOLI helixturnhelix swissprot:GLNA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLNA_ECOLI hmoment swissprot:GLNA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLNA_ECOLI iep swissprot:GLNA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLNA_ECOLI inforesidue swissprot:GLNA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLNA_ECOLI octanol swissprot:GLNA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLNA_ECOLI pepcoil swissprot:GLNA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLNA_ECOLI pepdigest swissprot:GLNA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLNA_ECOLI pepinfo swissprot:GLNA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLNA_ECOLI pepnet swissprot:GLNA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLNA_ECOLI pepstats swissprot:GLNA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLNA_ECOLI pepwheel swissprot:GLNA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLNA_ECOLI pepwindow swissprot:GLNA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLNA_ECOLI sigcleave swissprot:GLNA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLNA_ECOLI ## Database ID URL or Descriptions # EcoGene EG40006 insF2 # FUNCTION INSF2_ECOLI Involved in the transposition of the insertion sequence IS3. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006310 DNA recombination; IEA:UniProtKB-KW. # GO_process GO:0015074 DNA integration; IEA:InterPro. # GO_process GO:0032196 transposition; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 3.30.420.10 -; 1. # InterPro IPR001584 Integrase_cat-core # InterPro IPR012337 RNaseH-like_dom # InterPro IPR025948 HTH-like_dom # Organism INSF2_ECOLI Escherichia coli (strain K12) # PIR C64756 TQECI3 # PROSITE PS50994 INTEGRASE # Pfam PF00665 rve # Pfam PF13276 HTH_21 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSF2_ECOLI Transposase InsF for insertion sequence IS3B # RefSeq NP_061381 NC_002483.1 # RefSeq NP_414833 NC_000913.3 # RefSeq NP_414906 NC_000913.3 # RefSeq NP_415073 NC_000913.3 # RefSeq NP_415545 NC_000913.3 # RefSeq NP_416593 NC_000913.3 # RefSeq WP_000878218 NZ_LN832404.1 # SIMILARITY Belongs to the transposase IS3/IS150/IS904 family. {ECO 0000305}. # SIMILARITY Contains 1 integrase catalytic domain. {ECO:0000255|PROSITE-ProRule PRU00457}. # SUPFAM SSF53098 SSF53098 # eggNOG COG2801 LUCA BLAST swissprot:INSF2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSF2_ECOLI DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB4716 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4716 EcoGene EG40006 http://www.ecogene.org/geneInfo.php?eg_id=EG40006 EnsemblBacteria AAC73475 http://www.ensemblgenomes.org/id/AAC73475 EnsemblBacteria AAC73475 http://www.ensemblgenomes.org/id/AAC73475 EnsemblBacteria BAE76153 http://www.ensemblgenomes.org/id/BAE76153 EnsemblBacteria BAE76153 http://www.ensemblgenomes.org/id/BAE76153 EnsemblBacteria BAE76153 http://www.ensemblgenomes.org/id/BAE76153 EnsemblBacteria b0372 http://www.ensemblgenomes.org/id/b0372 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0015074 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015074 GO_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 3.30.420.10 http://www.cathdb.info/version/latest/superfamily/3.30.420.10 GeneID 1263587 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263587 GeneID 944948 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944948 GeneID 945036 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945036 GeneID 945587 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945587 GeneID 946629 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946629 GeneID 947988 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947988 InParanoid P0CF80 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CF80 InterPro IPR001584 http://www.ebi.ac.uk/interpro/entry/IPR001584 InterPro IPR012337 http://www.ebi.ac.uk/interpro/entry/IPR012337 InterPro IPR025948 http://www.ebi.ac.uk/interpro/entry/IPR025948 KEGG_Gene ecj:JW0363 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0363 KEGG_Gene eco:b0299 http://www.genome.jp/dbget-bin/www_bget?eco:b0299 KEGG_Gene eco:b0372 http://www.genome.jp/dbget-bin/www_bget?eco:b0372 KEGG_Gene eco:b0541 http://www.genome.jp/dbget-bin/www_bget?eco:b0541 KEGG_Gene eco:b1026 http://www.genome.jp/dbget-bin/www_bget?eco:b1026 KEGG_Gene eco:b2089 http://www.genome.jp/dbget-bin/www_bget?eco:b2089 PROSITE PS50994 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50994 PSORT swissprot:INSF2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSF2_ECOLI PSORT-B swissprot:INSF2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSF2_ECOLI PSORT2 swissprot:INSF2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSF2_ECOLI Pfam PF00665 http://pfam.xfam.org/family/PF00665 Pfam PF13276 http://pfam.xfam.org/family/PF13276 Phobius swissprot:INSF2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSF2_ECOLI PhylomeDB P0CF80 http://phylomedb.org/?seqid=P0CF80 ProteinModelPortal P0CF80 http://www.proteinmodelportal.org/query/uniprot/P0CF80 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_061381 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061381 RefSeq NP_414833 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414833 RefSeq NP_414906 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414906 RefSeq NP_415073 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415073 RefSeq NP_415545 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415545 RefSeq NP_416593 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416593 RefSeq WP_000878218 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000878218 SMR P0CF80 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0CF80 STRING 511145.b2089 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2089&targetmode=cogs SUPFAM SSF53098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098 UniProtKB INSF2_ECOLI http://www.uniprot.org/uniprot/INSF2_ECOLI UniProtKB-AC P0CF80 http://www.uniprot.org/uniprot/P0CF80 charge swissprot:INSF2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSF2_ECOLI eggNOG COG2801 http://eggnogapi.embl.de/nog_data/html/tree/COG2801 epestfind swissprot:INSF2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSF2_ECOLI garnier swissprot:INSF2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSF2_ECOLI helixturnhelix swissprot:INSF2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSF2_ECOLI hmoment swissprot:INSF2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSF2_ECOLI iep swissprot:INSF2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSF2_ECOLI inforesidue swissprot:INSF2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSF2_ECOLI octanol swissprot:INSF2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSF2_ECOLI pepcoil swissprot:INSF2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSF2_ECOLI pepdigest swissprot:INSF2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSF2_ECOLI pepinfo swissprot:INSF2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSF2_ECOLI pepnet swissprot:INSF2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSF2_ECOLI pepstats swissprot:INSF2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSF2_ECOLI pepwheel swissprot:INSF2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSF2_ECOLI pepwindow swissprot:INSF2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSF2_ECOLI sigcleave swissprot:INSF2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSF2_ECOLI ## Database ID URL or Descriptions # BioGrid 4262183 10 # DISRUPTION PHENOTYPE No alteration in fatty acid composition. {ECO:0000269|PubMed 19854834}. # EcoGene EG11395 yijD # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # IntAct P0AF40 2 # InterPro IPR009867 DUF1422 # MISCELLANEOUS Probably part of the fabR-yijD operon. {ECO:0000305|PubMed 19854834}. # Organism YIJD_ECOLI Escherichia coli (strain K12) # PATRIC 32123449 VBIEscCol129921_4085 # PIR G65203 G65203 # PIR S21565 S21565 # Pfam PF07226 DUF1422 # ProDom PD076479 DUF1422 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIJD_ECOLI Inner membrane protein YijD # RefSeq NP_418399 NC_000913.3 # RefSeq WP_000806411 NZ_LN832404.1 # SUBCELLULAR LOCATION YIJD_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000305}. # eggNOG ENOG4108Y73 Bacteria # eggNOG ENOG4111S45 LUCA BLAST swissprot:YIJD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIJD_ECOLI BioCyc ECOL316407:JW3936-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3936-MONOMER BioCyc EcoCyc:EG11395-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11395-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M109.068239 http://dx.doi.org/10.1074/jbc.M109.068239 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X66026 http://www.ebi.ac.uk/ena/data/view/X66026 EchoBASE EB1368 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1368 EcoGene EG11395 http://www.ecogene.org/geneInfo.php?eg_id=EG11395 EnsemblBacteria AAC76946 http://www.ensemblgenomes.org/id/AAC76946 EnsemblBacteria AAC76946 http://www.ensemblgenomes.org/id/AAC76946 EnsemblBacteria BAE77347 http://www.ensemblgenomes.org/id/BAE77347 EnsemblBacteria BAE77347 http://www.ensemblgenomes.org/id/BAE77347 EnsemblBacteria BAE77347 http://www.ensemblgenomes.org/id/BAE77347 EnsemblBacteria b3964 http://www.ensemblgenomes.org/id/b3964 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 948459 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948459 HOGENOM HOG000270375 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000270375&db=HOGENOM6 IntAct P0AF40 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AF40* InterPro IPR009867 http://www.ebi.ac.uk/interpro/entry/IPR009867 KEGG_Gene ecj:JW3936 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3936 KEGG_Gene eco:b3964 http://www.genome.jp/dbget-bin/www_bget?eco:b3964 OMA GSNFFAI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GSNFFAI PSORT swissprot:YIJD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIJD_ECOLI PSORT-B swissprot:YIJD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIJD_ECOLI PSORT2 swissprot:YIJD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIJD_ECOLI Pfam PF07226 http://pfam.xfam.org/family/PF07226 Phobius swissprot:YIJD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIJD_ECOLI ProteinModelPortal P0AF40 http://www.proteinmodelportal.org/query/uniprot/P0AF40 PubMed 1447162 http://www.ncbi.nlm.nih.gov/pubmed/1447162 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19854834 http://www.ncbi.nlm.nih.gov/pubmed/19854834 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418399 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418399 RefSeq WP_000806411 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000806411 STRING 511145.b3964 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3964&targetmode=cogs UniProtKB YIJD_ECOLI http://www.uniprot.org/uniprot/YIJD_ECOLI UniProtKB-AC P0AF40 http://www.uniprot.org/uniprot/P0AF40 charge swissprot:YIJD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIJD_ECOLI eggNOG ENOG4108Y73 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Y73 eggNOG ENOG4111S45 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111S45 epestfind swissprot:YIJD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIJD_ECOLI garnier swissprot:YIJD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIJD_ECOLI helixturnhelix swissprot:YIJD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIJD_ECOLI hmoment swissprot:YIJD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIJD_ECOLI iep swissprot:YIJD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIJD_ECOLI inforesidue swissprot:YIJD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIJD_ECOLI octanol swissprot:YIJD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIJD_ECOLI pepcoil swissprot:YIJD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIJD_ECOLI pepdigest swissprot:YIJD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIJD_ECOLI pepinfo swissprot:YIJD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIJD_ECOLI pepnet swissprot:YIJD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIJD_ECOLI pepstats swissprot:YIJD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIJD_ECOLI pepwheel swissprot:YIJD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIJD_ECOLI pepwindow swissprot:YIJD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIJD_ECOLI sigcleave swissprot:YIJD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIJD_ECOLI ## Database ID URL or Descriptions # AltName DNA-invertase PinQ {ECO 0000305} # AltName PINQ_ECOLI Putative DNA-invertase from lambdoid prophage Qin # AltName Site-specific recombinase PinQ {ECO 0000305} # BioGrid 4260217 202 # EcoGene EG13824 pinQ # GO_function GO:0000150 recombinase activity; IBA:GO_Central. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0016787 hydrolase activity; IEA:UniProtKB-KW. # GO_function GO:0016874 ligase activity; IEA:UniProtKB-KW. # GO_process GO:0015074 DNA integration; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016874 ligase activity # GOslim_process GO:0006259 DNA metabolic process # Gene3D 1.10.10.60 -; 1. # Gene3D 3.40.50.1390 -; 1. # InterPro IPR006118 Recombinase_CS # InterPro IPR006119 Resolv_N # InterPro IPR006120 Resolvase_HTH_dom # InterPro IPR009057 Homeodomain-like # Organism PINQ_ECOLI Escherichia coli (strain K12) # PATRIC 32118390 VBIEscCol129921_1615 # PIR D64909 D64909 # PROSITE PS00398 RECOMBINASES_2 # PROSITE PS51736 RECOMBINASES_3 # Pfam PF00239 Resolvase # Pfam PF02796 HTH_7 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Serine recombinase PinQ {ECO:0000250|UniProtKB P03015} # RefSeq NP_416063 NC_000913.3 # RefSeq WP_000078177 NZ_LN832404.1 # SIMILARITY Belongs to the site-specific recombinase resolvase family. {ECO 0000305}. # SIMILARITY Contains 1 resolvase/invertase-type recombinase catalytic domain. {ECO:0000255|PROSITE-ProRule PRU01072}. # SMART SM00857 Resolvase # SUPFAM SSF46689 SSF46689 # SUPFAM SSF53041 SSF53041 # eggNOG COG1961 LUCA # eggNOG ENOG4105MN3 Bacteria BLAST swissprot:PINQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PINQ_ECOLI BioCyc ECOL316407:JW1538-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1538-MONOMER BioCyc EcoCyc:G6819-MONOMER http://biocyc.org/getid?id=EcoCyc:G6819-MONOMER DIP DIP-10508N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10508N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.22.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.22.- EC_number EC:6.5.1.- http://www.genome.jp/dbget-bin/www_bget?EC:6.5.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.22.- http://enzyme.expasy.org/EC/3.1.22.- ENZYME 6.5.1.- http://enzyme.expasy.org/EC/6.5.1.- EchoBASE EB3585 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3585 EcoGene EG13824 http://www.ecogene.org/geneInfo.php?eg_id=EG13824 EnsemblBacteria AAC74618 http://www.ensemblgenomes.org/id/AAC74618 EnsemblBacteria AAC74618 http://www.ensemblgenomes.org/id/AAC74618 EnsemblBacteria BAA15249 http://www.ensemblgenomes.org/id/BAA15249 EnsemblBacteria BAA15249 http://www.ensemblgenomes.org/id/BAA15249 EnsemblBacteria BAA15249 http://www.ensemblgenomes.org/id/BAA15249 EnsemblBacteria b1545 http://www.ensemblgenomes.org/id/b1545 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000150 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0016787 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016787 GO_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GO_process GO:0015074 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015074 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 Gene3D 3.40.50.1390 http://www.cathdb.info/version/latest/superfamily/3.40.50.1390 GeneID 946088 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946088 HOGENOM HOG000275578 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275578&db=HOGENOM6 InParanoid P77170 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77170 IntAct P77170 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77170* IntEnz 3.1.22 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.22 IntEnz 6.5.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.5.1 InterPro IPR006118 http://www.ebi.ac.uk/interpro/entry/IPR006118 InterPro IPR006119 http://www.ebi.ac.uk/interpro/entry/IPR006119 InterPro IPR006120 http://www.ebi.ac.uk/interpro/entry/IPR006120 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 KEGG_Gene ecj:JW1538 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1538 KEGG_Gene eco:b1545 http://www.genome.jp/dbget-bin/www_bget?eco:b1545 OMA NIAYIRV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NIAYIRV PROSITE PS00398 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00398 PROSITE PS51736 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51736 PSORT swissprot:PINQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PINQ_ECOLI PSORT-B swissprot:PINQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PINQ_ECOLI PSORT2 swissprot:PINQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PINQ_ECOLI Pfam PF00239 http://pfam.xfam.org/family/PF00239 Pfam PF02796 http://pfam.xfam.org/family/PF02796 Phobius swissprot:PINQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PINQ_ECOLI PhylomeDB P77170 http://phylomedb.org/?seqid=P77170 ProteinModelPortal P77170 http://www.proteinmodelportal.org/query/uniprot/P77170 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416063 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416063 RefSeq WP_000078177 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000078177 SMART SM00857 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00857 SMR P77170 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77170 STRING 511145.b1545 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1545&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF53041 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53041 UniProtKB PINQ_ECOLI http://www.uniprot.org/uniprot/PINQ_ECOLI UniProtKB-AC P77170 http://www.uniprot.org/uniprot/P77170 charge swissprot:PINQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PINQ_ECOLI eggNOG COG1961 http://eggnogapi.embl.de/nog_data/html/tree/COG1961 eggNOG ENOG4105MN3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105MN3 epestfind swissprot:PINQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PINQ_ECOLI garnier swissprot:PINQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PINQ_ECOLI helixturnhelix swissprot:PINQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PINQ_ECOLI hmoment swissprot:PINQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PINQ_ECOLI iep swissprot:PINQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PINQ_ECOLI inforesidue swissprot:PINQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PINQ_ECOLI octanol swissprot:PINQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PINQ_ECOLI pepcoil swissprot:PINQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PINQ_ECOLI pepdigest swissprot:PINQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PINQ_ECOLI pepinfo swissprot:PINQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PINQ_ECOLI pepnet swissprot:PINQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PINQ_ECOLI pepstats swissprot:PINQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PINQ_ECOLI pepwheel swissprot:PINQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PINQ_ECOLI pepwindow swissprot:PINQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PINQ_ECOLI sigcleave swissprot:PINQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PINQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4260462 26 # COFACTOR YEIL_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000305|PubMed 11101674}; Note=Binds 1 [4Fe-4S] cluster per subunit. {ECO 0000305|PubMed 11101674}; # EcoGene EG12031 yeiL # FUNCTION YEIL_ECOLI Transcription regulator involved in mid-term, stationary-phase viability under nitrogen starvation. Might control expression of the salvage pathways or in some other way repress the recycling of nucleobases to nucleic acids and enhance their use as general nitrogen sources during nitrogen-limited growth. {ECO 0000269|PubMed 11101674}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEP:EcoCyc. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; ISS:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 2.60.120.10 -; 1. # INDUCTION In the stationary phase, aerobic expression is positively autoregulated and significantly dependent on RpoS and Lrp. Its transcription is directly or indirectly repressed by FNR. {ECO:0000269|PubMed 11101674}. # InterPro IPR000595 cNMP-bd_dom # InterPro IPR012318 HTH_CRP # InterPro IPR014710 RmlC-like_jellyroll # InterPro IPR018490 cNMP-bd-like # KEGG_Brite ko03000 Transcription factors # MISCELLANEOUS YEIL_ECOLI Its activity might be modulated by a sensory iron- sulfur cluster, by reversible dithiol-disulfide formation, or by both mechanisms. It is not an oxygen-responsive regulator. # Organism YEIL_ECOLI Escherichia coli (strain K12) # PATRIC 32119675 VBIEscCol129921_2248 # PIR B64985 B64985 # PROSITE PS50042 CNMP_BINDING_3 # PROSITE PS51063 HTH_CRP_2 # Pfam PF00027 cNMP_binding # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEIL_ECOLI Regulatory protein YeiL # RefSeq NP_416668 NC_000913.3 # SIMILARITY Contains 1 HTH crp-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00387}. # SIMILARITY Contains 1 cyclic nucleotide-binding domain. {ECO:0000255|PROSITE-ProRule PRU00060}. # SMART SM00100 cNMP # SUBCELLULAR LOCATION YEIL_ECOLI Cytoplasm {ECO 0000305|PubMed 11101674}. # SUBUNIT Homodimer. {ECO:0000305|PubMed 11101674}. # SUPFAM SSF51206 SSF51206 # eggNOG COG0664 LUCA # eggNOG ENOG4108Y4K Bacteria BLAST swissprot:YEIL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEIL_ECOLI BioCyc ECOL316407:JW2150-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2150-MONOMER BioCyc EcoCyc:EG12031-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12031-MONOMER COG COG0664 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0664 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1966 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1966 EcoGene EG12031 http://www.ecogene.org/geneInfo.php?eg_id=EG12031 EnsemblBacteria AAC75224 http://www.ensemblgenomes.org/id/AAC75224 EnsemblBacteria AAC75224 http://www.ensemblgenomes.org/id/AAC75224 EnsemblBacteria BAE76640 http://www.ensemblgenomes.org/id/BAE76640 EnsemblBacteria BAE76640 http://www.ensemblgenomes.org/id/BAE76640 EnsemblBacteria BAE76640 http://www.ensemblgenomes.org/id/BAE76640 EnsemblBacteria b2163 http://www.ensemblgenomes.org/id/b2163 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 2.60.120.10 http://www.cathdb.info/version/latest/superfamily/2.60.120.10 GeneID 946670 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946670 HOGENOM HOG000094699 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000094699&db=HOGENOM6 InterPro IPR000595 http://www.ebi.ac.uk/interpro/entry/IPR000595 InterPro IPR012318 http://www.ebi.ac.uk/interpro/entry/IPR012318 InterPro IPR014710 http://www.ebi.ac.uk/interpro/entry/IPR014710 InterPro IPR018490 http://www.ebi.ac.uk/interpro/entry/IPR018490 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW2150 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2150 KEGG_Gene eco:b2163 http://www.genome.jp/dbget-bin/www_bget?eco:b2163 KEGG_Orthology KO:K16326 http://www.genome.jp/dbget-bin/www_bget?KO:K16326 OMA QDATFLQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QDATFLQ PROSITE PS50042 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50042 PROSITE PS51063 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51063 PSORT swissprot:YEIL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEIL_ECOLI PSORT-B swissprot:YEIL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEIL_ECOLI PSORT2 swissprot:YEIL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEIL_ECOLI Pfam PF00027 http://pfam.xfam.org/family/PF00027 Phobius swissprot:YEIL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEIL_ECOLI PhylomeDB P0A9E9 http://phylomedb.org/?seqid=P0A9E9 ProteinModelPortal P0A9E9 http://www.proteinmodelportal.org/query/uniprot/P0A9E9 PubMed 11101674 http://www.ncbi.nlm.nih.gov/pubmed/11101674 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416668 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416668 SMART SM00100 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00100 SMR P0A9E9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9E9 STRING 511145.b2163 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2163&targetmode=cogs STRING COG0664 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0664&targetmode=cogs SUPFAM SSF51206 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51206 UniProtKB YEIL_ECOLI http://www.uniprot.org/uniprot/YEIL_ECOLI UniProtKB-AC P0A9E9 http://www.uniprot.org/uniprot/P0A9E9 charge swissprot:YEIL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEIL_ECOLI eggNOG COG0664 http://eggnogapi.embl.de/nog_data/html/tree/COG0664 eggNOG ENOG4108Y4K http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Y4K epestfind swissprot:YEIL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEIL_ECOLI garnier swissprot:YEIL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEIL_ECOLI helixturnhelix swissprot:YEIL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEIL_ECOLI hmoment swissprot:YEIL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEIL_ECOLI iep swissprot:YEIL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEIL_ECOLI inforesidue swissprot:YEIL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEIL_ECOLI octanol swissprot:YEIL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEIL_ECOLI pepcoil swissprot:YEIL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEIL_ECOLI pepdigest swissprot:YEIL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEIL_ECOLI pepinfo swissprot:YEIL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEIL_ECOLI pepnet swissprot:YEIL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEIL_ECOLI pepstats swissprot:YEIL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEIL_ECOLI pepwheel swissprot:YEIL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEIL_ECOLI pepwindow swissprot:YEIL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEIL_ECOLI sigcleave swissprot:YEIL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEIL_ECOLI ## Database ID URL or Descriptions # AltName XAPR_ECOLI Xanthosine operon regulatory protein # BioGrid 4262007 5 # EcoGene EG11146 xapR # FUNCTION XAPR_ECOLI Positive regulator required for the expression of xapA and xapB. Binds to the inducer xanthosine. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # IntAct P23841 5 # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR005119 LysR_subst-bd # InterPro IPR011991 WHTH_DNA-bd_dom # Organism XAPR_ECOLI Escherichia coli (strain K12) # PATRIC 32120189 VBIEscCol129921_2497 # PIR S11407 S11407 # PRINTS PR00039 HTHLYSR # PROSITE PS50931 HTH_LYSR # Pfam PF00126 HTH_1 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName XAPR_ECOLI HTH-type transcriptional regulator XapR # RefSeq NP_416900 NC_000913.3 # RefSeq WP_000442949 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lysR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00253}. # SUPFAM SSF46785 SSF46785 # eggNOG ENOG4105CN8 Bacteria # eggNOG ENOG410YMSV LUCA BLAST swissprot:XAPR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:XAPR_ECOLI BioCyc ECOL316407:JW2396-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2396-MONOMER BioCyc EcoCyc:EG11146-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11146-MONOMER DOI 10.1016/0022-2836(90)90339-N http://dx.doi.org/10.1016/0022-2836(90)90339-N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M13687 http://www.ebi.ac.uk/ena/data/view/M13687 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X63976 http://www.ebi.ac.uk/ena/data/view/X63976 EMBL X73828 http://www.ebi.ac.uk/ena/data/view/X73828 EchoBASE EB1136 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1136 EcoGene EG11146 http://www.ecogene.org/geneInfo.php?eg_id=EG11146 EnsemblBacteria AAC75458 http://www.ensemblgenomes.org/id/AAC75458 EnsemblBacteria AAC75458 http://www.ensemblgenomes.org/id/AAC75458 EnsemblBacteria BAA16273 http://www.ensemblgenomes.org/id/BAA16273 EnsemblBacteria BAA16273 http://www.ensemblgenomes.org/id/BAA16273 EnsemblBacteria BAA16273 http://www.ensemblgenomes.org/id/BAA16273 EnsemblBacteria b2405 http://www.ensemblgenomes.org/id/b2405 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 946862 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946862 HOGENOM HOG000233514 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000233514&db=HOGENOM6 InParanoid P23841 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23841 IntAct P23841 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P23841* InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW2396 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2396 KEGG_Gene eco:b2405 http://www.genome.jp/dbget-bin/www_bget?eco:b2405 OMA HEANNIN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HEANNIN PRINTS PR00039 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00039 PROSITE PS50931 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50931 PSORT swissprot:XAPR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:XAPR_ECOLI PSORT-B swissprot:XAPR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:XAPR_ECOLI PSORT2 swissprot:XAPR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:XAPR_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:XAPR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:XAPR_ECOLI PhylomeDB P23841 http://phylomedb.org/?seqid=P23841 ProteinModelPortal P23841 http://www.proteinmodelportal.org/query/uniprot/P23841 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2201776 http://www.ncbi.nlm.nih.gov/pubmed/2201776 PubMed 7559336 http://www.ncbi.nlm.nih.gov/pubmed/7559336 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416900 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416900 RefSeq WP_000442949 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000442949 SMR P23841 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P23841 STRING 511145.b2405 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2405&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB XAPR_ECOLI http://www.uniprot.org/uniprot/XAPR_ECOLI UniProtKB-AC P23841 http://www.uniprot.org/uniprot/P23841 charge swissprot:XAPR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:XAPR_ECOLI eggNOG ENOG4105CN8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CN8 eggNOG ENOG410YMSV http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YMSV epestfind swissprot:XAPR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:XAPR_ECOLI garnier swissprot:XAPR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:XAPR_ECOLI helixturnhelix swissprot:XAPR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:XAPR_ECOLI hmoment swissprot:XAPR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:XAPR_ECOLI iep swissprot:XAPR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:XAPR_ECOLI inforesidue swissprot:XAPR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:XAPR_ECOLI octanol swissprot:XAPR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:XAPR_ECOLI pepcoil swissprot:XAPR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:XAPR_ECOLI pepdigest swissprot:XAPR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:XAPR_ECOLI pepinfo swissprot:XAPR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:XAPR_ECOLI pepnet swissprot:XAPR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:XAPR_ECOLI pepstats swissprot:XAPR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:XAPR_ECOLI pepwheel swissprot:XAPR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:XAPR_ECOLI pepwindow swissprot:XAPR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:XAPR_ECOLI sigcleave swissprot:XAPR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:XAPR_ECOLI ## Database ID URL or Descriptions # BioGrid 4260293 15 # EcoGene EG13977 ydiR # FUNCTION YDIR_ECOLI May play a role in a redox process. # GO_function GO:0000062 fatty-acyl-CoA binding; IBA:GO_Central. # GO_function GO:0003995 acyl-CoA dehydrogenase activity; IBA:GO_Central. # GO_function GO:0009055 electron carrier activity; IBA:GO_Central. # GO_function GO:0016491 oxidoreductase activity; IBA:GO_Central. # GO_function GO:0050660 flavin adenine dinucleotide binding; IBA:GO_Central. # GO_function GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor; IBA:GO_Central. # GO_process GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase; IBA:GO_Central. # GO_process GO:0055088 lipid homeostasis; IBA:GO_Central. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0042592 homeostatic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.1220 -; 1. # Gene3D 3.40.50.620 -; 1. # IntAct P77378 4 # InterPro IPR001308 ETF_a/FixB # InterPro IPR014729 Rossmann-like_a/b/a_fold # InterPro IPR014730 ETF_a/b_N # InterPro IPR014731 ETF_asu_C # InterPro IPR018206 ETF_asu_C_CS # InterPro IPR029035 DHS-like_NAD/FAD-binding_dom # Organism YDIR_ECOLI Escherichia coli (strain K12) # PATRIC 32118702 VBIEscCol129921_1769 # PIR B64928 B64928 # PIRSF PIRSF000089 Electra_flavoP_a # PROSITE PS00696 ETF_ALPHA # Pfam PF00766 ETF_alpha # Pfam PF01012 ETF # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDIR_ECOLI Putative electron transfer flavoprotein subunit YdiR # RefSeq NP_416213 NC_000913.3 # RefSeq WP_000080722 NZ_LN832404.1 # SIMILARITY Belongs to the ETF alpha-subunit/FixB family. {ECO 0000305}. # SMART SM00893 ETF # SUBUNIT YdiR and YdiQ form a heterodimer. {ECO 0000305}. # SUPFAM SSF52467 SSF52467 # eggNOG COG2025 LUCA # eggNOG ENOG4105C10 Bacteria BLAST swissprot:YDIR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDIR_ECOLI BioCyc ECOL316407:JW1688-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1688-MONOMER BioCyc EcoCyc:G6921-MONOMER http://biocyc.org/getid?id=EcoCyc:G6921-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3734 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3734 EcoGene EG13977 http://www.ecogene.org/geneInfo.php?eg_id=EG13977 EnsemblBacteria AAC74768 http://www.ensemblgenomes.org/id/AAC74768 EnsemblBacteria AAC74768 http://www.ensemblgenomes.org/id/AAC74768 EnsemblBacteria BAA15467 http://www.ensemblgenomes.org/id/BAA15467 EnsemblBacteria BAA15467 http://www.ensemblgenomes.org/id/BAA15467 EnsemblBacteria BAA15467 http://www.ensemblgenomes.org/id/BAA15467 EnsemblBacteria b1698 http://www.ensemblgenomes.org/id/b1698 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000062 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000062 GO_function GO:0003995 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003995 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_function GO:0052890 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052890 GO_process GO:0033539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033539 GO_process GO:0055088 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055088 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.1220 http://www.cathdb.info/version/latest/superfamily/3.40.50.1220 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 GeneID 945688 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945688 HOGENOM HOG000247866 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000247866&db=HOGENOM6 InParanoid P77378 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77378 IntAct P77378 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77378* InterPro IPR001308 http://www.ebi.ac.uk/interpro/entry/IPR001308 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 InterPro IPR014730 http://www.ebi.ac.uk/interpro/entry/IPR014730 InterPro IPR014731 http://www.ebi.ac.uk/interpro/entry/IPR014731 InterPro IPR018206 http://www.ebi.ac.uk/interpro/entry/IPR018206 InterPro IPR029035 http://www.ebi.ac.uk/interpro/entry/IPR029035 KEGG_Gene ecj:JW1688 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1688 KEGG_Gene eco:b1698 http://www.genome.jp/dbget-bin/www_bget?eco:b1698 OMA AKINHPV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AKINHPV PROSITE PS00696 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00696 PSORT swissprot:YDIR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDIR_ECOLI PSORT-B swissprot:YDIR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDIR_ECOLI PSORT2 swissprot:YDIR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDIR_ECOLI Pfam PF00766 http://pfam.xfam.org/family/PF00766 Pfam PF01012 http://pfam.xfam.org/family/PF01012 Phobius swissprot:YDIR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDIR_ECOLI PhylomeDB P77378 http://phylomedb.org/?seqid=P77378 ProteinModelPortal P77378 http://www.proteinmodelportal.org/query/uniprot/P77378 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416213 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416213 RefSeq WP_000080722 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000080722 SMART SM00893 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00893 SMR P77378 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77378 STRING 511145.b1698 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1698&targetmode=cogs SUPFAM SSF52467 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52467 UniProtKB YDIR_ECOLI http://www.uniprot.org/uniprot/YDIR_ECOLI UniProtKB-AC P77378 http://www.uniprot.org/uniprot/P77378 charge swissprot:YDIR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDIR_ECOLI eggNOG COG2025 http://eggnogapi.embl.de/nog_data/html/tree/COG2025 eggNOG ENOG4105C10 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C10 epestfind swissprot:YDIR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDIR_ECOLI garnier swissprot:YDIR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDIR_ECOLI helixturnhelix swissprot:YDIR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDIR_ECOLI hmoment swissprot:YDIR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDIR_ECOLI iep swissprot:YDIR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDIR_ECOLI inforesidue swissprot:YDIR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDIR_ECOLI octanol swissprot:YDIR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDIR_ECOLI pepcoil swissprot:YDIR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDIR_ECOLI pepdigest swissprot:YDIR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDIR_ECOLI pepinfo swissprot:YDIR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDIR_ECOLI pepnet swissprot:YDIR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDIR_ECOLI pepstats swissprot:YDIR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDIR_ECOLI pepwheel swissprot:YDIR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDIR_ECOLI pepwindow swissprot:YDIR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDIR_ECOLI sigcleave swissprot:YDIR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDIR_ECOLI ## Database ID URL or Descriptions # AltName ALLP_ECOLI Allantoin transport protein # BioGrid 4262820 180 # EcoGene EG13618 ybbW # FUNCTION ALLP_ECOLI Transport of allantoin. {ECO 0000250}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015205 nucleobase transmembrane transporter activity; IBA:GO_Central. # GO_process GO:0006144 purine nucleobase metabolic process; IEA:UniProtKB-KW. # GO_process GO:0015851 nucleobase transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # INDUCTION ALLP_ECOLI By glyoxylate. # InterPro IPR001248 Pur-cyt_permease # InterPro IPR012681 NCS1 # Organism ALLP_ECOLI Escherichia coli (strain K12) # PATRIC 32116179 VBIEscCol129921_0531 # PIR F64782 F64782 # Pfam PF02133 Transp_cyt_pur # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ALLP_ECOLI Putative allantoin permease # RefSeq NP_415044 NC_000913.3 # RefSeq WP_000401100 NZ_LN832404.1 # SIMILARITY Belongs to the purine-cytosine permease (2.A.39) family. {ECO 0000305}. # SUBCELLULAR LOCATION ALLP_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.39.3:the nucleobase cation symporter-1 (ncs1) family # TIGRFAMs TIGR00800 ncs1 # eggNOG COG1953 LUCA # eggNOG ENOG4105EW8 Bacteria BLAST swissprot:ALLP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ALLP_ECOLI BioCyc ECOL316407:JW0499-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0499-MONOMER BioCyc EcoCyc:B0511-MONOMER http://biocyc.org/getid?id=EcoCyc:B0511-MONOMER COG COG1953 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1953 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL U89279 http://www.ebi.ac.uk/ena/data/view/U89279 EchoBASE EB3383 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3383 EcoGene EG13618 http://www.ecogene.org/geneInfo.php?eg_id=EG13618 EnsemblBacteria AAC73613 http://www.ensemblgenomes.org/id/AAC73613 EnsemblBacteria AAC73613 http://www.ensemblgenomes.org/id/AAC73613 EnsemblBacteria BAE76289 http://www.ensemblgenomes.org/id/BAE76289 EnsemblBacteria BAE76289 http://www.ensemblgenomes.org/id/BAE76289 EnsemblBacteria BAE76289 http://www.ensemblgenomes.org/id/BAE76289 EnsemblBacteria b0511 http://www.ensemblgenomes.org/id/b0511 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015205 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015205 GO_process GO:0006144 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006144 GO_process GO:0015851 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015851 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 945138 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945138 HOGENOM HOG000165632 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000165632&db=HOGENOM6 InParanoid P75712 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75712 InterPro IPR001248 http://www.ebi.ac.uk/interpro/entry/IPR001248 InterPro IPR012681 http://www.ebi.ac.uk/interpro/entry/IPR012681 KEGG_Gene ecj:JW0499 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0499 KEGG_Gene eco:b0511 http://www.genome.jp/dbget-bin/www_bget?eco:b0511 KEGG_Orthology KO:K10975 http://www.genome.jp/dbget-bin/www_bget?KO:K10975 OMA NLAPRRI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NLAPRRI PSORT swissprot:ALLP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ALLP_ECOLI PSORT-B swissprot:ALLP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ALLP_ECOLI PSORT2 swissprot:ALLP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ALLP_ECOLI Pfam PF02133 http://pfam.xfam.org/family/PF02133 Phobius swissprot:ALLP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ALLP_ECOLI PhylomeDB P75712 http://phylomedb.org/?seqid=P75712 ProteinModelPortal P75712 http://www.proteinmodelportal.org/query/uniprot/P75712 PubMed 10601204 http://www.ncbi.nlm.nih.gov/pubmed/10601204 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415044 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415044 RefSeq WP_000401100 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000401100 STRING 511145.b0511 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0511&targetmode=cogs STRING COG1953 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1953&targetmode=cogs TCDB 2.A.39.3 http://www.tcdb.org/search/result.php?tc=2.A.39.3 TIGRFAMs TIGR00800 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00800 UniProtKB ALLP_ECOLI http://www.uniprot.org/uniprot/ALLP_ECOLI UniProtKB-AC P75712 http://www.uniprot.org/uniprot/P75712 charge swissprot:ALLP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ALLP_ECOLI eggNOG COG1953 http://eggnogapi.embl.de/nog_data/html/tree/COG1953 eggNOG ENOG4105EW8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EW8 epestfind swissprot:ALLP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ALLP_ECOLI garnier swissprot:ALLP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ALLP_ECOLI helixturnhelix swissprot:ALLP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ALLP_ECOLI hmoment swissprot:ALLP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ALLP_ECOLI iep swissprot:ALLP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ALLP_ECOLI inforesidue swissprot:ALLP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ALLP_ECOLI octanol swissprot:ALLP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ALLP_ECOLI pepcoil swissprot:ALLP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ALLP_ECOLI pepdigest swissprot:ALLP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ALLP_ECOLI pepinfo swissprot:ALLP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ALLP_ECOLI pepnet swissprot:ALLP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ALLP_ECOLI pepstats swissprot:ALLP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ALLP_ECOLI pepwheel swissprot:ALLP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ALLP_ECOLI pepwindow swissprot:ALLP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ALLP_ECOLI sigcleave swissprot:ALLP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ALLP_ECOLI ## Database ID URL or Descriptions # AltName ANMK_ECOLI AnhMurNAc kinase # BIOPHYSICOCHEMICAL PROPERTIES ANMK_ECOLI Kinetic parameters KM=1 mM for anhMurNAc {ECO 0000269|PubMed 15901686}; KM=1 mM for ATP {ECO 0000269|PubMed 15901686}; Vmax=180 umol/min/mg enzyme {ECO 0000269|PubMed 15901686}; pH dependence Optimum pH is 10-11. Inactive at pH 4.5. {ECO 0000269|PubMed 15901686}; # BioGrid 4263491 6 # CATALYTIC ACTIVITY ATP + 1,6-anhydro-N-acetyl-beta-muramate + H(2)O = ADP + N-acetylmuramate 6-phosphate. {ECO:0000269|PubMed 15901686}. # ENZYME REGULATION Strongly inhibited by ADP. {ECO:0000269|PubMed 15901686}. # EcoGene EG13942 anmK # FUNCTION ANMK_ECOLI Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. {ECO 0000269|PubMed 15901686, ECO 0000269|PubMed 16452451}. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0016301 kinase activity; IDA:EcoCyc. # GO_function GO:0016773 phosphotransferase activity, alcohol group as acceptor; IEA:UniProtKB-HAMAP. # GO_process GO:0005975 carbohydrate metabolic process; IEA:UniProtKB-KW. # GO_process GO:0006040 amino sugar metabolic process; IEA:UniProtKB-HAMAP. # GO_process GO:0009254 peptidoglycan turnover; IEA:UniProtKB-HAMAP. # GO_process GO:0097175 1,6-anhydro-N-acetyl-beta-muramic acid catabolic process; IEA:UniProtKB-UniPathway. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # HAMAP MF_01270 AnhMurNAc_kinase # IntAct P77570 7 # InterPro IPR005338 Anhydro_N_Ac-Mur_kinase # KEGG_Brite ko01000 Enzymes # Organism ANMK_ECOLI Escherichia coli (strain K12) # PATHWAY ANMK_ECOLI Amino-sugar metabolism; 1,6-anhydro-N-acetylmuramate degradation. # PATHWAY ANMK_ECOLI Cell wall biogenesis; peptidoglycan recycling. # PATRIC 32118582 VBIEscCol129921_1711 # PIR B64921 B64921 # Pfam PF03702 AnmK # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ANMK_ECOLI Anhydro-N-acetylmuramic acid kinase # RefSeq NP_416157 NC_000913.3 # RefSeq WP_000835039 NZ_LN832404.1 # SIMILARITY Belongs to the anhydro-N-acetylmuramic acid kinase family. {ECO 0000305}. # eggNOG COG2377 LUCA # eggNOG ENOG4105ED7 Bacteria BLAST swissprot:ANMK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ANMK_ECOLI BioCyc ECOL316407:JW1632-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1632-MONOMER BioCyc EcoCyc:G6880-MONOMER http://biocyc.org/getid?id=EcoCyc:G6880-MONOMER BioCyc MetaCyc:G6880-MONOMER http://biocyc.org/getid?id=MetaCyc:G6880-MONOMER COG COG2377 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2377 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.187.11.3643-3649.2005 http://dx.doi.org/10.1128/JB.187.11.3643-3649.2005 DOI 10.1128/JB.188.4.1660-1662.2006 http://dx.doi.org/10.1128/JB.188.4.1660-1662.2006 EC_number EC:2.7.1.170 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.170 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.170 http://enzyme.expasy.org/EC/2.7.1.170 EchoBASE EB3700 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3700 EcoGene EG13942 http://www.ecogene.org/geneInfo.php?eg_id=EG13942 EnsemblBacteria AAC74712 http://www.ensemblgenomes.org/id/AAC74712 EnsemblBacteria AAC74712 http://www.ensemblgenomes.org/id/AAC74712 EnsemblBacteria BAA15401 http://www.ensemblgenomes.org/id/BAA15401 EnsemblBacteria BAA15401 http://www.ensemblgenomes.org/id/BAA15401 EnsemblBacteria BAA15401 http://www.ensemblgenomes.org/id/BAA15401 EnsemblBacteria b1640 http://www.ensemblgenomes.org/id/b1640 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_function GO:0016773 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016773 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GO_process GO:0006040 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006040 GO_process GO:0009254 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009254 GO_process GO:0097175 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097175 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 946810 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946810 HAMAP MF_01270 http://hamap.expasy.org/unirule/MF_01270 HOGENOM HOG000256309 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000256309&db=HOGENOM6 InParanoid P77570 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77570 IntAct P77570 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77570* IntEnz 2.7.1.170 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.170 InterPro IPR005338 http://www.ebi.ac.uk/interpro/entry/IPR005338 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1632 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1632 KEGG_Gene eco:b1640 http://www.genome.jp/dbget-bin/www_bget?eco:b1640 KEGG_Orthology KO:K09001 http://www.genome.jp/dbget-bin/www_bget?KO:K09001 OMA GCHGQTI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GCHGQTI PSORT swissprot:ANMK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ANMK_ECOLI PSORT-B swissprot:ANMK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ANMK_ECOLI PSORT2 swissprot:ANMK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ANMK_ECOLI Pfam PF03702 http://pfam.xfam.org/family/PF03702 Phobius swissprot:ANMK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ANMK_ECOLI PhylomeDB P77570 http://phylomedb.org/?seqid=P77570 ProteinModelPortal P77570 http://www.proteinmodelportal.org/query/uniprot/P77570 PubMed 15901686 http://www.ncbi.nlm.nih.gov/pubmed/15901686 PubMed 16452451 http://www.ncbi.nlm.nih.gov/pubmed/16452451 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416157 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416157 RefSeq WP_000835039 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000835039 SMR P77570 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77570 STRING 511145.b1640 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1640&targetmode=cogs STRING COG2377 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2377&targetmode=cogs UniProtKB ANMK_ECOLI http://www.uniprot.org/uniprot/ANMK_ECOLI UniProtKB-AC P77570 http://www.uniprot.org/uniprot/P77570 charge swissprot:ANMK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ANMK_ECOLI eggNOG COG2377 http://eggnogapi.embl.de/nog_data/html/tree/COG2377 eggNOG ENOG4105ED7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ED7 epestfind swissprot:ANMK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ANMK_ECOLI garnier swissprot:ANMK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ANMK_ECOLI helixturnhelix swissprot:ANMK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ANMK_ECOLI hmoment swissprot:ANMK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ANMK_ECOLI iep swissprot:ANMK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ANMK_ECOLI inforesidue swissprot:ANMK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ANMK_ECOLI octanol swissprot:ANMK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ANMK_ECOLI pepcoil swissprot:ANMK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ANMK_ECOLI pepdigest swissprot:ANMK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ANMK_ECOLI pepinfo swissprot:ANMK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ANMK_ECOLI pepnet swissprot:ANMK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ANMK_ECOLI pepstats swissprot:ANMK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ANMK_ECOLI pepwheel swissprot:ANMK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ANMK_ECOLI pepwindow swissprot:ANMK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ANMK_ECOLI sigcleave swissprot:ANMK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ANMK_ECOLI ## Database ID URL or Descriptions # AltName YDCC_ECOLI ORF-H # BioGrid 4262890 61 # EcoGene EG11526 ydcC # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # IntAct P28917 3 # InterPro IPR002559 Transposase_11 # InterPro IPR032806 YbfD_N # Organism YDCC_ECOLI Escherichia coli (strain K12) # PATRIC 32118212 VBIEscCol129921_1526 # PIR G64898 G64898 # Pfam PF01609 DDE_Tnp_1 # Pfam PF13808 DDE_Tnp_1_assoc # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDCC_ECOLI H repeat-associated protein YdcC # RefSeq NP_415977 NC_000913.3 # RefSeq WP_000421020 NZ_LN832404.1 # SIMILARITY Belongs to the transposase 11 family. {ECO 0000305}. # eggNOG COG5433 LUCA # eggNOG ENOG410600T Bacteria BLAST swissprot:YDCC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDCC_ECOLI BioCyc ECOL316407:JW1455-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1455-MONOMER BioCyc EcoCyc:EG11526-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11526-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L02372 http://www.ebi.ac.uk/ena/data/view/L02372 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X60998 http://www.ebi.ac.uk/ena/data/view/X60998 EchoBASE EB1488 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1488 EcoGene EG11526 http://www.ecogene.org/geneInfo.php?eg_id=EG11526 EnsemblBacteria AAC74542 http://www.ensemblgenomes.org/id/AAC74542 EnsemblBacteria AAC74542 http://www.ensemblgenomes.org/id/AAC74542 EnsemblBacteria BAA15091 http://www.ensemblgenomes.org/id/BAA15091 EnsemblBacteria BAA15091 http://www.ensemblgenomes.org/id/BAA15091 EnsemblBacteria BAA15091 http://www.ensemblgenomes.org/id/BAA15091 EnsemblBacteria b1460 http://www.ensemblgenomes.org/id/b1460 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GeneID 947435 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947435 HOGENOM HOG000042098 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000042098&db=HOGENOM6 InParanoid P28917 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P28917 IntAct P28917 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P28917* InterPro IPR002559 http://www.ebi.ac.uk/interpro/entry/IPR002559 InterPro IPR032806 http://www.ebi.ac.uk/interpro/entry/IPR032806 KEGG_Gene ecj:JW1455 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1455 KEGG_Gene eco:b1460 http://www.genome.jp/dbget-bin/www_bget?eco:b1460 OMA RHISINI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RHISINI PSORT swissprot:YDCC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDCC_ECOLI PSORT-B swissprot:YDCC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDCC_ECOLI PSORT2 swissprot:YDCC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDCC_ECOLI Pfam PF01609 http://pfam.xfam.org/family/PF01609 Pfam PF13808 http://pfam.xfam.org/family/PF13808 Phobius swissprot:YDCC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDCC_ECOLI PhylomeDB P28917 http://phylomedb.org/?seqid=P28917 ProteinModelPortal P28917 http://www.proteinmodelportal.org/query/uniprot/P28917 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8387990 http://www.ncbi.nlm.nih.gov/pubmed/8387990 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415977 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415977 RefSeq WP_000421020 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000421020 SMR P28917 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P28917 STRING 511145.b1460 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1460&targetmode=cogs UniProtKB YDCC_ECOLI http://www.uniprot.org/uniprot/YDCC_ECOLI UniProtKB-AC P28917 http://www.uniprot.org/uniprot/P28917 charge swissprot:YDCC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDCC_ECOLI eggNOG COG5433 http://eggnogapi.embl.de/nog_data/html/tree/COG5433 eggNOG ENOG410600T http://eggnogapi.embl.de/nog_data/html/tree/ENOG410600T epestfind swissprot:YDCC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDCC_ECOLI garnier swissprot:YDCC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDCC_ECOLI helixturnhelix swissprot:YDCC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDCC_ECOLI hmoment swissprot:YDCC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDCC_ECOLI iep swissprot:YDCC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDCC_ECOLI inforesidue swissprot:YDCC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDCC_ECOLI octanol swissprot:YDCC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDCC_ECOLI pepcoil swissprot:YDCC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDCC_ECOLI pepdigest swissprot:YDCC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDCC_ECOLI pepinfo swissprot:YDCC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDCC_ECOLI pepnet swissprot:YDCC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDCC_ECOLI pepstats swissprot:YDCC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDCC_ECOLI pepwheel swissprot:YDCC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDCC_ECOLI pepwindow swissprot:YDCC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDCC_ECOLI sigcleave swissprot:YDCC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDCC_ECOLI ## Database ID URL or Descriptions # BioGrid 4260825 13 # EcoGene EG12665 flgN # FUNCTION FLGN_ECOLI Required for the efficient initiation of filament assembly. {ECO 0000250}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_process GO:0044780 bacterial-type flagellum assembly; IEA:InterPro. # GOslim_component GO:0005737 cytoplasm # GOslim_process GO:0022607 cellular component assembly # Gene3D 1.20.58.300 -; 1. # INTERACTION FLGN_ECOLI P33235 flgK; NbExp=3; IntAct=EBI-1121833, EBI-551382; # IntAct P43533 9 # InterPro IPR007809 FlgN-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Pathway ko02040 Flagellar assembly # Organism FLGN_ECOLI Escherichia coli (strain K12) # PATRIC 32117379 VBIEscCol129921_1112 # PIR C64850 C64850 # Pfam PF05130 FlgN # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FLGN_ECOLI Flagella synthesis protein FlgN # RefSeq NP_415588 NC_000913.3 # RefSeq WP_000197363 NZ_LN832404.1 # SIMILARITY Belongs to the FlgN family. {ECO 0000305}. # SUBCELLULAR LOCATION FLGN_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF140566 SSF140566 # eggNOG COG3418 LUCA # eggNOG ENOG4105QVD Bacteria BLAST swissprot:FLGN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLGN_ECOLI BioCyc ECOL316407:JW1057-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1057-MONOMER BioCyc EcoCyc:G6562-MONOMER http://biocyc.org/getid?id=EcoCyc:G6562-MONOMER COG COG3418 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3418 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U19773 http://www.ebi.ac.uk/ena/data/view/U19773 EchoBASE EB2531 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2531 EcoGene EG12665 http://www.ecogene.org/geneInfo.php?eg_id=EG12665 EnsemblBacteria AAC74154 http://www.ensemblgenomes.org/id/AAC74154 EnsemblBacteria AAC74154 http://www.ensemblgenomes.org/id/AAC74154 EnsemblBacteria BAA35878 http://www.ensemblgenomes.org/id/BAA35878 EnsemblBacteria BAA35878 http://www.ensemblgenomes.org/id/BAA35878 EnsemblBacteria BAA35878 http://www.ensemblgenomes.org/id/BAA35878 EnsemblBacteria b1070 http://www.ensemblgenomes.org/id/b1070 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_process GO:0044780 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044780 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 Gene3D 1.20.58.300 http://www.cathdb.info/version/latest/superfamily/1.20.58.300 GeneID 945634 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945634 HOGENOM HOG000119028 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000119028&db=HOGENOM6 IntAct P43533 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P43533* InterPro IPR007809 http://www.ebi.ac.uk/interpro/entry/IPR007809 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW1057 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1057 KEGG_Gene eco:b1070 http://www.genome.jp/dbget-bin/www_bget?eco:b1070 KEGG_Orthology KO:K02399 http://www.genome.jp/dbget-bin/www_bget?KO:K02399 KEGG_Pathway ko02040 http://www.genome.jp/kegg-bin/show_pathway?ko02040 OMA KNQHNGL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KNQHNGL PSORT swissprot:FLGN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLGN_ECOLI PSORT-B swissprot:FLGN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLGN_ECOLI PSORT2 swissprot:FLGN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLGN_ECOLI Pfam PF05130 http://pfam.xfam.org/family/PF05130 Phobius swissprot:FLGN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLGN_ECOLI ProteinModelPortal P43533 http://www.proteinmodelportal.org/query/uniprot/P43533 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415588 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415588 RefSeq WP_000197363 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000197363 SMR P43533 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P43533 STRING 511145.b1070 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1070&targetmode=cogs STRING COG3418 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3418&targetmode=cogs SUPFAM SSF140566 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF140566 UniProtKB FLGN_ECOLI http://www.uniprot.org/uniprot/FLGN_ECOLI UniProtKB-AC P43533 http://www.uniprot.org/uniprot/P43533 charge swissprot:FLGN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLGN_ECOLI eggNOG COG3418 http://eggnogapi.embl.de/nog_data/html/tree/COG3418 eggNOG ENOG4105QVD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105QVD epestfind swissprot:FLGN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLGN_ECOLI garnier swissprot:FLGN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLGN_ECOLI helixturnhelix swissprot:FLGN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLGN_ECOLI hmoment swissprot:FLGN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLGN_ECOLI iep swissprot:FLGN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLGN_ECOLI inforesidue swissprot:FLGN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLGN_ECOLI octanol swissprot:FLGN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLGN_ECOLI pepcoil swissprot:FLGN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLGN_ECOLI pepdigest swissprot:FLGN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLGN_ECOLI pepinfo swissprot:FLGN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLGN_ECOLI pepnet swissprot:FLGN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLGN_ECOLI pepstats swissprot:FLGN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLGN_ECOLI pepwheel swissprot:FLGN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLGN_ECOLI pepwindow swissprot:FLGN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLGN_ECOLI sigcleave swissprot:FLGN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLGN_ECOLI ## Database ID URL or Descriptions # EcoGene EG40014 insN # FUNCTION INSN1_ECOLI Involved in the transposition of the insertion sequence IS911. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 1.10.10.60 -; 1. # IntAct P75679 68 # InterPro IPR002514 Transposase_8 # InterPro IPR009057 Homeodomain-like # Organism INSN1_ECOLI Escherichia coli (strain K12) # PATRIC 48659707 VBIEscCol107702_0250 # PIR G64750 G64750 # Pfam PF01527 HTH_Tnp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSN1_ECOLI Transposase InsN for insertion sequence element IS911A # SEQUENCE CAUTION Sequence=AAB08674.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the transposase 8 family. {ECO 0000305}. # SUPFAM SSF46689 SSF46689 # eggNOG COG2963 LUCA # eggNOG ENOG4105PBD Bacteria BLAST swissprot:INSN1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSN1_ECOLI BioCyc ECOL316407:JW5024-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5024-MONOMER BioCyc EcoCyc:G6130-MONOMER http://biocyc.org/getid?id=EcoCyc:G6130-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EchoBASE EB4702 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4702 EcoGene EG40014 http://www.ecogene.org/geneInfo.php?eg_id=EG40014 EnsemblBacteria BAA77925 http://www.ensemblgenomes.org/id/BAA77925 EnsemblBacteria BAA77925 http://www.ensemblgenomes.org/id/BAA77925 EnsemblBacteria BAA77925 http://www.ensemblgenomes.org/id/BAA77925 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 HOGENOM HOG000023132 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000023132&db=HOGENOM6 InParanoid P75679 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75679 IntAct P75679 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75679* InterPro IPR002514 http://www.ebi.ac.uk/interpro/entry/IPR002514 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 KEGG_Gene ecj:JW5024 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5024 OMA GASMKKR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GASMKKR PSORT swissprot:INSN1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSN1_ECOLI PSORT-B swissprot:INSN1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSN1_ECOLI PSORT2 swissprot:INSN1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSN1_ECOLI Pfam PF01527 http://pfam.xfam.org/family/PF01527 Phobius swissprot:INSN1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSN1_ECOLI ProteinModelPortal P75679 http://www.proteinmodelportal.org/query/uniprot/P75679 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 STRING 316407.4902991 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.4902991&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 UniProtKB INSN1_ECOLI http://www.uniprot.org/uniprot/INSN1_ECOLI UniProtKB-AC P75679 http://www.uniprot.org/uniprot/P75679 charge swissprot:INSN1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSN1_ECOLI eggNOG COG2963 http://eggnogapi.embl.de/nog_data/html/tree/COG2963 eggNOG ENOG4105PBD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105PBD epestfind swissprot:INSN1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSN1_ECOLI garnier swissprot:INSN1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSN1_ECOLI helixturnhelix swissprot:INSN1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSN1_ECOLI hmoment swissprot:INSN1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSN1_ECOLI iep swissprot:INSN1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSN1_ECOLI inforesidue swissprot:INSN1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSN1_ECOLI octanol swissprot:INSN1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSN1_ECOLI pepcoil swissprot:INSN1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSN1_ECOLI pepdigest swissprot:INSN1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSN1_ECOLI pepinfo swissprot:INSN1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSN1_ECOLI pepnet swissprot:INSN1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSN1_ECOLI pepstats swissprot:INSN1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSN1_ECOLI pepwheel swissprot:INSN1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSN1_ECOLI pepwindow swissprot:INSN1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSN1_ECOLI sigcleave swissprot:INSN1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSN1_ECOLI ## Database ID URL or Descriptions # AltName EUTC_ECOLI Ethanolamine ammonia-lyase small subunit # BRENDA 4.3.1 2026 # BioGrid 4260577 11 # CATALYTIC ACTIVITY EUTC_ECOLI Ethanolamine = acetaldehyde + NH(3). # COFACTOR Name=adenosylcob(III)alamin; Xref=ChEBI:CHEBI 18408; # EcoGene EG50007 eutC # GO_component GO:0009350 ethanolamine ammonia-lyase complex; IDA:EcoCyc. # GO_function GO:0008851 ethanolamine ammonia-lyase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0031419 cobalamin binding; IEA:UniProtKB-KW. # GO_process GO:0006520 cellular amino acid metabolic process; IEA:InterPro. # GO_process GO:0046336 ethanolamine catabolic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # HAMAP MF_00601 EutC # IntAct P19636 30 # InterPro IPR009246 EutC # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00564 Glycerophospholipid metabolism # Organism EUTC_ECOLI Escherichia coli (strain K12) # PATHWAY EUTC_ECOLI Amine and polyamine degradation; ethanolamine degradation. # PATRIC 32120265 VBIEscCol129921_2535 # PDB 3ABO X-ray; 2.10 A; B/D=1-295 # PDB 3ABQ X-ray; 2.05 A; B/D=1-295 # PDB 3ABR X-ray; 2.10 A; B/D=1-295 # PDB 3ABS X-ray; 2.25 A; B/D=1-295 # PDB 3ANY X-ray; 2.10 A; B/D=44-295 # PDB 3AO0 X-ray; 2.25 A; B/D=44-295 # PIR G65018 G65018 # PIRSF PIRSF018982 EutC # Pfam PF05985 EutC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EUTC_ECOLI Ethanolamine ammonia-lyase light chain # RefSeq NP_416935 NC_000913.3 # RefSeq WP_000372316 NZ_LN832404.1 # SIMILARITY Belongs to the EutC family. {ECO 0000305}. # SUBUNIT EUTC_ECOLI Heterodimer of a small and a large subunit. # eggNOG COG4302 LUCA # eggNOG ENOG4107FQ9 Bacteria BLAST swissprot:EUTC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EUTC_ECOLI BioCyc ECOL316407:JW2433-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2433-MONOMER BioCyc EcoCyc:EUTC-MONOMER http://biocyc.org/getid?id=EcoCyc:EUTC-MONOMER BioCyc MetaCyc:EUTC-MONOMER http://biocyc.org/getid?id=MetaCyc:EUTC-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.3.1.7 http://www.genome.jp/dbget-bin/www_bget?EC:4.3.1.7 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 4.3.1.7 http://enzyme.expasy.org/EC/4.3.1.7 EchoBASE EB4300 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4300 EcoGene EG50007 http://www.ecogene.org/geneInfo.php?eg_id=EG50007 EnsemblBacteria AAC75493 http://www.ensemblgenomes.org/id/AAC75493 EnsemblBacteria AAC75493 http://www.ensemblgenomes.org/id/AAC75493 EnsemblBacteria BAA16322 http://www.ensemblgenomes.org/id/BAA16322 EnsemblBacteria BAA16322 http://www.ensemblgenomes.org/id/BAA16322 EnsemblBacteria BAA16322 http://www.ensemblgenomes.org/id/BAA16322 EnsemblBacteria b2440 http://www.ensemblgenomes.org/id/b2440 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009350 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009350 GO_function GO:0008851 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008851 GO_function GO:0031419 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031419 GO_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GO_process GO:0046336 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046336 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 946925 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946925 HAMAP MF_00601 http://hamap.expasy.org/unirule/MF_00601 HOGENOM HOG000253991 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000253991&db=HOGENOM6 InParanoid P19636 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P19636 IntAct P19636 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P19636* IntEnz 4.3.1.7 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.3.1.7 InterPro IPR009246 http://www.ebi.ac.uk/interpro/entry/IPR009246 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2433 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2433 KEGG_Gene eco:b2440 http://www.genome.jp/dbget-bin/www_bget?eco:b2440 KEGG_Orthology KO:K03736 http://www.genome.jp/dbget-bin/www_bget?KO:K03736 KEGG_Pathway ko00564 http://www.genome.jp/kegg-bin/show_pathway?ko00564 KEGG_Reaction rn:R00749 http://www.genome.jp/dbget-bin/www_bget?rn:R00749 OMA CKDKDEY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CKDKDEY PDB 3ABO http://www.ebi.ac.uk/pdbe-srv/view/entry/3ABO PDB 3ABQ http://www.ebi.ac.uk/pdbe-srv/view/entry/3ABQ PDB 3ABR http://www.ebi.ac.uk/pdbe-srv/view/entry/3ABR PDB 3ABS http://www.ebi.ac.uk/pdbe-srv/view/entry/3ABS PDB 3ANY http://www.ebi.ac.uk/pdbe-srv/view/entry/3ANY PDB 3AO0 http://www.ebi.ac.uk/pdbe-srv/view/entry/3AO0 PDBsum 3ABO http://www.ebi.ac.uk/pdbsum/3ABO PDBsum 3ABQ http://www.ebi.ac.uk/pdbsum/3ABQ PDBsum 3ABR http://www.ebi.ac.uk/pdbsum/3ABR PDBsum 3ABS http://www.ebi.ac.uk/pdbsum/3ABS PDBsum 3ANY http://www.ebi.ac.uk/pdbsum/3ANY PDBsum 3AO0 http://www.ebi.ac.uk/pdbsum/3AO0 PSORT swissprot:EUTC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EUTC_ECOLI PSORT-B swissprot:EUTC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EUTC_ECOLI PSORT2 swissprot:EUTC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EUTC_ECOLI Pfam PF05985 http://pfam.xfam.org/family/PF05985 Phobius swissprot:EUTC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EUTC_ECOLI PhylomeDB P19636 http://phylomedb.org/?seqid=P19636 ProteinModelPortal P19636 http://www.proteinmodelportal.org/query/uniprot/P19636 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2197274 http://www.ncbi.nlm.nih.gov/pubmed/2197274 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416935 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416935 RefSeq WP_000372316 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000372316 SMR P19636 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P19636 STRING 511145.b2440 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2440&targetmode=cogs UniProtKB EUTC_ECOLI http://www.uniprot.org/uniprot/EUTC_ECOLI UniProtKB-AC P19636 http://www.uniprot.org/uniprot/P19636 charge swissprot:EUTC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EUTC_ECOLI eggNOG COG4302 http://eggnogapi.embl.de/nog_data/html/tree/COG4302 eggNOG ENOG4107FQ9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107FQ9 epestfind swissprot:EUTC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EUTC_ECOLI garnier swissprot:EUTC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EUTC_ECOLI helixturnhelix swissprot:EUTC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EUTC_ECOLI hmoment swissprot:EUTC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EUTC_ECOLI iep swissprot:EUTC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EUTC_ECOLI inforesidue swissprot:EUTC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EUTC_ECOLI octanol swissprot:EUTC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EUTC_ECOLI pepcoil swissprot:EUTC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EUTC_ECOLI pepdigest swissprot:EUTC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EUTC_ECOLI pepinfo swissprot:EUTC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EUTC_ECOLI pepnet swissprot:EUTC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EUTC_ECOLI pepstats swissprot:EUTC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EUTC_ECOLI pepwheel swissprot:EUTC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EUTC_ECOLI pepwindow swissprot:EUTC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EUTC_ECOLI sigcleave swissprot:EUTC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EUTC_ECOLI ## Database ID URL or Descriptions # BioGrid 4262551 4 # EcoGene EG12289 yiaU # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0000986 bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; ISS:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR005119 LysR_subst-bd # InterPro IPR011991 WHTH_DNA-bd_dom # Organism YIAU_ECOLI Escherichia coli (strain K12) # PATRIC 32122646 VBIEscCol129921_3700 # PIR S47806 S47806 # PROSITE PS50931 HTH_LYSR # Pfam PF00126 HTH_1 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIAU_ECOLI Uncharacterized HTH-type transcriptional regulator YiaU # RefSeq NP_418042 NC_000913.3 # RefSeq WP_000164036 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lysR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00253}. # SUPFAM SSF46785 SSF46785 # eggNOG ENOG4108Q2M Bacteria # eggNOG ENOG410ZXM0 LUCA BLAST swissprot:YIAU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIAU_ECOLI BioCyc ECOL316407:JW3557-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3557-MONOMER BioCyc EcoCyc:EG12289-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12289-MONOMER DIP DIP-12411N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12411N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2197 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2197 EcoGene EG12289 http://www.ecogene.org/geneInfo.php?eg_id=EG12289 EnsemblBacteria AAC76609 http://www.ensemblgenomes.org/id/AAC76609 EnsemblBacteria AAC76609 http://www.ensemblgenomes.org/id/AAC76609 EnsemblBacteria BAE77708 http://www.ensemblgenomes.org/id/BAE77708 EnsemblBacteria BAE77708 http://www.ensemblgenomes.org/id/BAE77708 EnsemblBacteria BAE77708 http://www.ensemblgenomes.org/id/BAE77708 EnsemblBacteria b3585 http://www.ensemblgenomes.org/id/b3585 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000986 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000986 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 948107 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948107 HOGENOM HOG000267780 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267780&db=HOGENOM6 InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW3557 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3557 KEGG_Gene eco:b3585 http://www.genome.jp/dbget-bin/www_bget?eco:b3585 OMA GIVYAPY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GIVYAPY PROSITE PS50931 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50931 PSORT swissprot:YIAU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIAU_ECOLI PSORT-B swissprot:YIAU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIAU_ECOLI PSORT2 swissprot:YIAU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIAU_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:YIAU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIAU_ECOLI PhylomeDB P37682 http://phylomedb.org/?seqid=P37682 ProteinModelPortal P37682 http://www.proteinmodelportal.org/query/uniprot/P37682 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418042 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418042 RefSeq WP_000164036 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000164036 SMR P37682 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37682 STRING 511145.b3585 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3585&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB YIAU_ECOLI http://www.uniprot.org/uniprot/YIAU_ECOLI UniProtKB-AC P37682 http://www.uniprot.org/uniprot/P37682 charge swissprot:YIAU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIAU_ECOLI eggNOG ENOG4108Q2M http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Q2M eggNOG ENOG410ZXM0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZXM0 epestfind swissprot:YIAU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIAU_ECOLI garnier swissprot:YIAU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIAU_ECOLI helixturnhelix swissprot:YIAU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIAU_ECOLI hmoment swissprot:YIAU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIAU_ECOLI iep swissprot:YIAU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIAU_ECOLI inforesidue swissprot:YIAU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIAU_ECOLI octanol swissprot:YIAU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIAU_ECOLI pepcoil swissprot:YIAU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIAU_ECOLI pepdigest swissprot:YIAU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIAU_ECOLI pepinfo swissprot:YIAU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIAU_ECOLI pepnet swissprot:YIAU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIAU_ECOLI pepstats swissprot:YIAU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIAU_ECOLI pepwheel swissprot:YIAU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIAU_ECOLI pepwindow swissprot:YIAU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIAU_ECOLI sigcleave swissprot:YIAU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIAU_ECOLI ## Database ID URL or Descriptions # EcoGene EG40008 insH9 # FUNCTION INSH9_ECOLI Involved in the transposition of the insertion sequence IS5. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # InterPro IPR002559 Transposase_11 # InterPro IPR008490 Transposase_InsH_N # Organism INSH9_ECOLI Escherichia coli (strain K12) # Pfam PF01609 DDE_Tnp_1 # Pfam PF05598 DUF772 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSH9_ECOLI Transposase InsH for insertion sequence element IS5LO # RefSeq NP_414793 NC_000913.3 # RefSeq NP_415084 NC_000913.3 # RefSeq NP_415189 NC_000913.3 # RefSeq NP_415847 NC_000913.3 # RefSeq NP_416535 NC_000913.3 # RefSeq NP_416696 NC_000913.3 # RefSeq NP_417456 NC_000913.3 # RefSeq NP_417685 NC_000913.3 # RefSeq NP_417962 NC_000913.3 # SIMILARITY Belongs to the transposase 11 family. {ECO 0000305}. # eggNOG COG3039 LUCA # eggNOG ENOG4105F2I Bacteria BLAST swissprot:INSH9_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSH9_ECOLI BioCyc EcoCyc:MONOMER0-4239 http://biocyc.org/getid?id=EcoCyc:MONOMER0-4239 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB4739 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4739 EcoGene EG40008 http://www.ecogene.org/geneInfo.php?eg_id=EG40008 EnsemblBacteria AAC76018 http://www.ensemblgenomes.org/id/AAC76018 EnsemblBacteria AAC76018 http://www.ensemblgenomes.org/id/AAC76018 EnsemblBacteria BAE77043 http://www.ensemblgenomes.org/id/BAE77043 EnsemblBacteria BAE77043 http://www.ensemblgenomes.org/id/BAE77043 EnsemblBacteria BAE77043 http://www.ensemblgenomes.org/id/BAE77043 EnsemblBacteria b2982 http://www.ensemblgenomes.org/id/b2982 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GeneID 944917 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944917 GeneID 944941 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944941 GeneID 945896 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945896 GeneID 946163 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946163 GeneID 946577 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946577 GeneID 947516 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947516 GeneID 947743 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947743 GeneID 948015 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948015 GeneID 949121 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949121 InParanoid P0CE56 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CE56 InterPro IPR002559 http://www.ebi.ac.uk/interpro/entry/IPR002559 InterPro IPR008490 http://www.ebi.ac.uk/interpro/entry/IPR008490 KEGG_Gene ecj:JW2949 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2949 KEGG_Gene eco:b0259 http://www.genome.jp/dbget-bin/www_bget?eco:b0259 KEGG_Gene eco:b0552 http://www.genome.jp/dbget-bin/www_bget?eco:b0552 KEGG_Gene eco:b0656 http://www.genome.jp/dbget-bin/www_bget?eco:b0656 KEGG_Gene eco:b1331 http://www.genome.jp/dbget-bin/www_bget?eco:b1331 KEGG_Gene eco:b2030 http://www.genome.jp/dbget-bin/www_bget?eco:b2030 KEGG_Gene eco:b2192 http://www.genome.jp/dbget-bin/www_bget?eco:b2192 KEGG_Gene eco:b2982 http://www.genome.jp/dbget-bin/www_bget?eco:b2982 KEGG_Gene eco:b3218 http://www.genome.jp/dbget-bin/www_bget?eco:b3218 KEGG_Gene eco:b3505 http://www.genome.jp/dbget-bin/www_bget?eco:b3505 PSORT swissprot:INSH9_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSH9_ECOLI PSORT-B swissprot:INSH9_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSH9_ECOLI PSORT2 swissprot:INSH9_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSH9_ECOLI Pfam PF01609 http://pfam.xfam.org/family/PF01609 Pfam PF05598 http://pfam.xfam.org/family/PF05598 Phobius swissprot:INSH9_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSH9_ECOLI PhylomeDB P0CE56 http://phylomedb.org/?seqid=P0CE56 ProteinModelPortal P0CE56 http://www.proteinmodelportal.org/query/uniprot/P0CE56 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414793 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414793 RefSeq NP_415084 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415084 RefSeq NP_415189 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415189 RefSeq NP_415847 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415847 RefSeq NP_416535 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416535 RefSeq NP_416696 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416696 RefSeq NP_417456 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417456 RefSeq NP_417685 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417685 RefSeq NP_417962 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417962 SMR P0CE56 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0CE56 STRING 511145.b3505 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3505&targetmode=cogs UniProtKB INSH9_ECOLI http://www.uniprot.org/uniprot/INSH9_ECOLI UniProtKB-AC P0CE56 http://www.uniprot.org/uniprot/P0CE56 charge swissprot:INSH9_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSH9_ECOLI eggNOG COG3039 http://eggnogapi.embl.de/nog_data/html/tree/COG3039 eggNOG ENOG4105F2I http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F2I epestfind swissprot:INSH9_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSH9_ECOLI garnier swissprot:INSH9_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSH9_ECOLI helixturnhelix swissprot:INSH9_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSH9_ECOLI hmoment swissprot:INSH9_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSH9_ECOLI iep swissprot:INSH9_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSH9_ECOLI inforesidue swissprot:INSH9_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSH9_ECOLI octanol swissprot:INSH9_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSH9_ECOLI pepcoil swissprot:INSH9_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSH9_ECOLI pepdigest swissprot:INSH9_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSH9_ECOLI pepinfo swissprot:INSH9_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSH9_ECOLI pepnet swissprot:INSH9_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSH9_ECOLI pepstats swissprot:INSH9_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSH9_ECOLI pepwheel swissprot:INSH9_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSH9_ECOLI pepwindow swissprot:INSH9_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSH9_ECOLI sigcleave swissprot:INSH9_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSH9_ECOLI ## Database ID URL or Descriptions # AltName DPIB_ECOLI Sensor histidine kinase CitA # BRENDA 2.7.13 2026 # BioGrid 4263372 13 # CATALYTIC ACTIVITY DPIB_ECOLI ATP + protein L-histidine = ADP + protein N- phospho-L-histidine. # DOMAIN DPIB_ECOLI The periplasmic domain binds citrate with high affinity. The C-terminal cytoplasmic domain senses reduced conditions using a single Cys in vitro. {ECO 0000269|PubMed 11889485, ECO 0000269|PubMed 19202292}. # ENZYME REGULATION Autophosphorylation is induced in vitro by dithiothreitol (DTT). {ECO:0000269|PubMed 19202292}. # EcoGene EG13646 dpiB # FUNCTION DPIB_ECOLI Member of the two-component regulatory system DpiA/DpiB, which is essential for expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. Could be involved in response to both the presence of citrate and external redox conditions. Functions as a sensor kinase that phosphorylates DpiA in the presence of citrate. {ECO 0000269|PubMed 11889485, ECO 0000269|PubMed 19202292}. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0000155 phosphorelay sensor kinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0000160 phosphorelay signal transduction system; IDA:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:InterPro. # GO_process GO:0018106 peptidyl-histidine phosphorylation; IDA:EcoCyc. # GO_process GO:0046777 protein autophosphorylation; IDA:EcoCyc. # GO_process GO:0071310 cellular response to organic substance; IEP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005622 intracellular # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # Gene3D 1.10.287.130 -; 1. # Gene3D 3.30.565.10 -; 1. # IntAct P77510 6 # InterPro IPR000014 PAS # InterPro IPR003594 HATPase_C # InterPro IPR003661 HisK_dim/P # InterPro IPR004358 Sig_transdc_His_kin-like_C # InterPro IPR005467 His_kinase_dom # InterPro IPR013767 PAS_fold # InterPro IPR016120 Sig_transdc_His_kin_SpoOB # InterPro IPR029151 Sensor-like # InterPro IPR033463 sCache_3 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01001 Protein kinases # KEGG_Brite ko02022 M00486 CitA-CitB (citrate fermentation) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # Organism DPIB_ECOLI Escherichia coli (strain K12) # PATRIC 32116418 VBIEscCol129921_0649 # PIR A64796 A64796 # PRINTS PR00344 BCTRLSENSOR # PROSITE PS50109 HIS_KIN # PTM DPIB_ECOLI Autophosphorylated. # Pfam PF00989 PAS # Pfam PF02518 HATPase_c # Pfam PF17203 sCache_3_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DPIB_ECOLI Sensor histidine kinase DpiB # RefSeq NP_415152 NC_000913.3 # RefSeq WP_000939767 NZ_LN832404.1 # SIMILARITY Contains 1 PAS (PER-ARNT-SIM) domain. {ECO 0000305}. # SIMILARITY Contains 1 histidine kinase domain. {ECO:0000255|PROSITE-ProRule PRU00107}. # SMART SM00091 PAS # SMART SM00387 HATPase_c # SUBCELLULAR LOCATION DPIB_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # SUPFAM SSF103190 SSF103190 # SUPFAM SSF55785 SSF55785 # SUPFAM SSF55874 SSF55874 # SUPFAM SSF55890 SSF55890 # eggNOG COG3290 LUCA # eggNOG ENOG4105CEQ Bacteria BLAST swissprot:DPIB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DPIB_ECOLI BioCyc ECOL316407:JW0611-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0611-MONOMER BioCyc EcoCyc:G6345-MONOMER http://biocyc.org/getid?id=EcoCyc:G6345-MONOMER COG COG3290 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3290 DOI 10.1007/s00203-001-0393-z http://dx.doi.org/10.1007/s00203-001-0393-z DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1998.00895.x http://dx.doi.org/10.1046/j.1365-2958.1998.00895.x DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1271/bbb.80586 http://dx.doi.org/10.1271/bbb.80586 EC_number EC:2.7.13.3 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.13.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U46667 http://www.ebi.ac.uk/ena/data/view/U46667 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 ENZYME 2.7.13.3 http://enzyme.expasy.org/EC/2.7.13.3 EchoBASE EB3410 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3410 EcoGene EG13646 http://www.ecogene.org/geneInfo.php?eg_id=EG13646 EnsemblBacteria AAC73720 http://www.ensemblgenomes.org/id/AAC73720 EnsemblBacteria AAC73720 http://www.ensemblgenomes.org/id/AAC73720 EnsemblBacteria BAA35255 http://www.ensemblgenomes.org/id/BAA35255 EnsemblBacteria BAA35255 http://www.ensemblgenomes.org/id/BAA35255 EnsemblBacteria BAA35255 http://www.ensemblgenomes.org/id/BAA35255 EnsemblBacteria b0619 http://www.ensemblgenomes.org/id/b0619 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0000155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000155 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0018106 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018106 GO_process GO:0046777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046777 GO_process GO:0071310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071310 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.10.287.130 http://www.cathdb.info/version/latest/superfamily/1.10.287.130 Gene3D 3.30.565.10 http://www.cathdb.info/version/latest/superfamily/3.30.565.10 GeneID 945233 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945233 HOGENOM HOG000241934 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000241934&db=HOGENOM6 IntAct P77510 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77510* IntEnz 2.7.13.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.13.3 InterPro IPR000014 http://www.ebi.ac.uk/interpro/entry/IPR000014 InterPro IPR003594 http://www.ebi.ac.uk/interpro/entry/IPR003594 InterPro IPR003661 http://www.ebi.ac.uk/interpro/entry/IPR003661 InterPro IPR004358 http://www.ebi.ac.uk/interpro/entry/IPR004358 InterPro IPR005467 http://www.ebi.ac.uk/interpro/entry/IPR005467 InterPro IPR013767 http://www.ebi.ac.uk/interpro/entry/IPR013767 InterPro IPR016120 http://www.ebi.ac.uk/interpro/entry/IPR016120 InterPro IPR029151 http://www.ebi.ac.uk/interpro/entry/IPR029151 InterPro IPR033463 http://www.ebi.ac.uk/interpro/entry/IPR033463 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01001 http://www.genome.jp/dbget-bin/www_bget?ko01001 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW0611 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0611 KEGG_Gene eco:b0619 http://www.genome.jp/dbget-bin/www_bget?eco:b0619 KEGG_Orthology KO:K07700 http://www.genome.jp/dbget-bin/www_bget?KO:K07700 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA RTQEGDN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RTQEGDN PRINTS PR00344 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00344 PROSITE PS50109 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50109 PSORT swissprot:DPIB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DPIB_ECOLI PSORT-B swissprot:DPIB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DPIB_ECOLI PSORT2 swissprot:DPIB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DPIB_ECOLI Pfam PF00989 http://pfam.xfam.org/family/PF00989 Pfam PF02518 http://pfam.xfam.org/family/PF02518 Pfam PF17203 http://pfam.xfam.org/family/PF17203 Phobius swissprot:DPIB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DPIB_ECOLI PhylomeDB P77510 http://phylomedb.org/?seqid=P77510 ProteinModelPortal P77510 http://www.proteinmodelportal.org/query/uniprot/P77510 PubMed 11889485 http://www.ncbi.nlm.nih.gov/pubmed/11889485 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19202292 http://www.ncbi.nlm.nih.gov/pubmed/19202292 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9701802 http://www.ncbi.nlm.nih.gov/pubmed/9701802 RefSeq NP_415152 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415152 RefSeq WP_000939767 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000939767 SMART SM00091 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00091 SMART SM00387 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00387 SMR P77510 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77510 STRING 511145.b0619 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0619&targetmode=cogs STRING COG3290 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3290&targetmode=cogs SUPFAM SSF103190 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103190 SUPFAM SSF55785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55785 SUPFAM SSF55874 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55874 SUPFAM SSF55890 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55890 UniProtKB DPIB_ECOLI http://www.uniprot.org/uniprot/DPIB_ECOLI UniProtKB-AC P77510 http://www.uniprot.org/uniprot/P77510 charge swissprot:DPIB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DPIB_ECOLI eggNOG COG3290 http://eggnogapi.embl.de/nog_data/html/tree/COG3290 eggNOG ENOG4105CEQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CEQ epestfind swissprot:DPIB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DPIB_ECOLI garnier swissprot:DPIB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DPIB_ECOLI helixturnhelix swissprot:DPIB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DPIB_ECOLI hmoment swissprot:DPIB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DPIB_ECOLI iep swissprot:DPIB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DPIB_ECOLI inforesidue swissprot:DPIB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DPIB_ECOLI octanol swissprot:DPIB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DPIB_ECOLI pepcoil swissprot:DPIB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DPIB_ECOLI pepdigest swissprot:DPIB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DPIB_ECOLI pepinfo swissprot:DPIB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DPIB_ECOLI pepnet swissprot:DPIB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DPIB_ECOLI pepstats swissprot:DPIB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DPIB_ECOLI pepwheel swissprot:DPIB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DPIB_ECOLI pepwindow swissprot:DPIB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DPIB_ECOLI sigcleave swissprot:DPIB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DPIB_ECOLI ## Database ID URL or Descriptions # AltName HDEB_ECOLI 10K-L protein # BioGrid 4261137 5 # DISRUPTION PHENOTYPE Mutants display increased sensitivity to acid stress at pH 2 and pH 3. {ECO:0000269|PubMed 17085547}. # EcoGene EG11399 hdeB # FUNCTION HDEB_ECOLI Required for optimal acid stress protection, which is important for survival of enteric bacteria in the acidic environment of the host stomach. Exhibits a chaperone-like activity at acidic pH by preventing the aggregation of many different periplasmic proteins. {ECO 0000255|HAMAP-Rule MF_00947, ECO 0000269|PubMed 17085547}. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_function GO:0051082 unfolded protein binding; IDA:EcoCyc. # GO_process GO:0009268 response to pH; IMP:EcoCyc. # GO_process GO:0033554 cellular response to stress; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0051082 unfolded protein binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # Gene3D 1.10.890.10 -; 1. # HAMAP MF_00947 HdeB # INDUCTION HDEB_ECOLI Induced by the EvgS/EvgA two-component regulatory system. Negatively regulated by H-NS and the TorS/TorR two- component regulatory system. {ECO 0000269|PubMed 12399493, ECO 0000269|PubMed 12657056, ECO 0000269|PubMed 16204188}. # InterPro IPR010486 HNS-dep_expression_A/B # InterPro IPR028623 HdeB # MASS SPECTROMETRY Mass=9065; Method=Electrospray; Range=30-108; Evidence={ECO:0000269|PubMed 12071744}; # MISCELLANEOUS In vitro, HdeA is more efficient than HdeB at pH 2 and HdeB is more efficient than HdeA at pH 3. In vivo, both are required for optimal protection against acid stress at either pH 3 or pH 2 (PubMed:17085547). {ECO 0000305|PubMed:17085547}. # Organism HDEB_ECOLI Escherichia coli (strain K12) # PATRIC 32122476 VBIEscCol129921_3616 # PDB 2MYJ NMR; -; A/B=30-108 # PDB 2XUV X-ray; 1.50 A; A/B/C/D=30-108 # PIR S30269 S30269 # Pfam PF06411 HdeA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Acid stress chaperone HdeB {ECO:0000255|HAMAP-Rule MF_00947} # RefSeq NP_417966 NC_000913.3 # RefSeq WP_001298717 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18485.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA01884.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the HdeB family. {ECO:0000255|HAMAP- Rule MF_00947}. # SUBCELLULAR LOCATION HDEB_ECOLI Periplasm {ECO 0000255|HAMAP-Rule MF_00947, ECO 0000269|PubMed 17085547}. # SUBUNIT HDEB_ECOLI Homodimer at neutral pH. Dissociates into monomers at acidic pH. {ECO 0000269|PubMed 17085547, ECO 0000269|PubMed 22138344}. # eggNOG ENOG4105XXV Bacteria # eggNOG ENOG41125MZ LUCA BLAST swissprot:HDEB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HDEB_ECOLI BioCyc ECOL316407:JW5669-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5669-MONOMER BioCyc EcoCyc:EG11399-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11399-MONOMER DIP DIP-47949N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47949N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1007/BF00282791 http://dx.doi.org/10.1007/BF00282791 DOI 10.1016/j.jmb.2011.11.026 http://dx.doi.org/10.1016/j.jmb.2011.11.026 DOI 10.1021/ja025966k http://dx.doi.org/10.1021/ja025966k DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2003.03428.x http://dx.doi.org/10.1046/j.1365-2958.2003.03428.x DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1101/gad.1316305 http://dx.doi.org/10.1101/gad.1316305 DOI 10.1111/j.1574-6968.1998.tb13343.x http://dx.doi.org/10.1111/j.1574-6968.1998.tb13343.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01522-06 http://dx.doi.org/10.1128/JB.01522-06 DOI 10.1128/JB.184.22.6225-6234.2002 http://dx.doi.org/10.1128/JB.184.22.6225-6234.2002 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D11109 http://www.ebi.ac.uk/ena/data/view/D11109 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1371 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1371 EcoGene EG11399 http://www.ecogene.org/geneInfo.php?eg_id=EG11399 EnsemblBacteria AAC76534 http://www.ensemblgenomes.org/id/AAC76534 EnsemblBacteria AAC76534 http://www.ensemblgenomes.org/id/AAC76534 EnsemblBacteria BAE77785 http://www.ensemblgenomes.org/id/BAE77785 EnsemblBacteria BAE77785 http://www.ensemblgenomes.org/id/BAE77785 EnsemblBacteria BAE77785 http://www.ensemblgenomes.org/id/BAE77785 EnsemblBacteria b3509 http://www.ensemblgenomes.org/id/b3509 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0051082 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051082 GO_process GO:0009268 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009268 GO_process GO:0033554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033554 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0051082 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051082 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.10.890.10 http://www.cathdb.info/version/latest/superfamily/1.10.890.10 GeneID 948026 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948026 HAMAP MF_00947 http://hamap.expasy.org/unirule/MF_00947 HOGENOM HOG000125815 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125815&db=HOGENOM6 InterPro IPR010486 http://www.ebi.ac.uk/interpro/entry/IPR010486 InterPro IPR028623 http://www.ebi.ac.uk/interpro/entry/IPR028623 KEGG_Gene ecj:JW5669 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5669 KEGG_Gene eco:b3509 http://www.genome.jp/dbget-bin/www_bget?eco:b3509 OMA MNIASLR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MNIASLR PDB 2MYJ http://www.ebi.ac.uk/pdbe-srv/view/entry/2MYJ PDB 2XUV http://www.ebi.ac.uk/pdbe-srv/view/entry/2XUV PDBsum 2MYJ http://www.ebi.ac.uk/pdbsum/2MYJ PDBsum 2XUV http://www.ebi.ac.uk/pdbsum/2XUV PSORT swissprot:HDEB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HDEB_ECOLI PSORT-B swissprot:HDEB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HDEB_ECOLI PSORT2 swissprot:HDEB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HDEB_ECOLI Pfam PF06411 http://pfam.xfam.org/family/PF06411 Phobius swissprot:HDEB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HDEB_ECOLI ProteinModelPortal P0AET2 http://www.proteinmodelportal.org/query/uniprot/P0AET2 PubMed 12071744 http://www.ncbi.nlm.nih.gov/pubmed/12071744 PubMed 12399493 http://www.ncbi.nlm.nih.gov/pubmed/12399493 PubMed 12657056 http://www.ncbi.nlm.nih.gov/pubmed/12657056 PubMed 16204188 http://www.ncbi.nlm.nih.gov/pubmed/16204188 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17085547 http://www.ncbi.nlm.nih.gov/pubmed/17085547 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 22138344 http://www.ncbi.nlm.nih.gov/pubmed/22138344 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 8244952 http://www.ncbi.nlm.nih.gov/pubmed/8244952 PubMed 8455549 http://www.ncbi.nlm.nih.gov/pubmed/8455549 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9868784 http://www.ncbi.nlm.nih.gov/pubmed/9868784 RefSeq NP_417966 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417966 RefSeq WP_001298717 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001298717 SMR P0AET2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AET2 STRING 511145.b3509 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3509&targetmode=cogs SWISS-2DPAGE P0AET2 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AET2 UniProtKB HDEB_ECOLI http://www.uniprot.org/uniprot/HDEB_ECOLI UniProtKB-AC P0AET2 http://www.uniprot.org/uniprot/P0AET2 charge swissprot:HDEB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HDEB_ECOLI eggNOG ENOG4105XXV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105XXV eggNOG ENOG41125MZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG41125MZ epestfind swissprot:HDEB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HDEB_ECOLI garnier swissprot:HDEB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HDEB_ECOLI helixturnhelix swissprot:HDEB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HDEB_ECOLI hmoment swissprot:HDEB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HDEB_ECOLI iep swissprot:HDEB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HDEB_ECOLI inforesidue swissprot:HDEB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HDEB_ECOLI octanol swissprot:HDEB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HDEB_ECOLI pepcoil swissprot:HDEB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HDEB_ECOLI pepdigest swissprot:HDEB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HDEB_ECOLI pepinfo swissprot:HDEB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HDEB_ECOLI pepnet swissprot:HDEB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HDEB_ECOLI pepstats swissprot:HDEB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HDEB_ECOLI pepwheel swissprot:HDEB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HDEB_ECOLI pepwindow swissprot:HDEB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HDEB_ECOLI sigcleave swissprot:HDEB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HDEB_ECOLI ## Database ID URL or Descriptions # AltName G6PI_ECOLI Phosphoglucose isomerase # AltName G6PI_ECOLI Phosphohexose isomerase # BioGrid 4261959 16 # CATALYTIC ACTIVITY G6PI_ECOLI D-glucose 6-phosphate = D-fructose 6- phosphate. # DISRUPTION PHENOTYPE G6PI_ECOLI One of the main features of pgi mutant is the overproduction of NADPH produced in pentose phosphate (PP) pathway which causes some reducing power imbalance that ultimately affects the cell growth. Cells lacking this gene grow slowly on glucose and utilize glucose primarily via the pentose phosphate pathway as the source of NADPH. They are also hypersensitive to oxidative stress induced by paraquat. {ECO 0000269|PubMed 14511906, ECO 0000269|PubMed 18368388}. # ENZYME REGULATION G6PI_ECOLI Inhibited by sorbitol-6-phosphate (S6P) and activated by CsrA. {ECO 0000269|PubMed 4344919, ECO 0000269|PubMed 7493933}. # EcoGene EG10702 pgi # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0004347 glucose-6-phosphate isomerase activity; IDA:EcoCyc. # GO_process GO:0006094 gluconeogenesis; IEA:UniProtKB-HAMAP. # GO_process GO:0006096 glycolytic process; IMP:EcoCyc. # GO_process GO:0034599 cellular response to oxidative stress; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 1.10.1390.10 -; 1. # HAMAP MF_00473 G6P_isomerase # INDUCTION Induced by oxidative stress. {ECO:0000269|PubMed 18368388}. # INTERACTION G6PI_ECOLI Self; NbExp=3; IntAct=EBI-909327, EBI-909327; # IntAct P0A6T1 7 # InterPro IPR001672 G6P_Isomerase # InterPro IPR018189 Phosphoglucose_isomerase_CS # InterPro IPR023096 G6P_Isomerase_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00010 Glycolysis / Gluconeogenesis # KEGG_Pathway ko00030 Pentose phosphate pathway # KEGG_Pathway ko00500 Starch and sucrose metabolism # KEGG_Pathway ko00520 Amino sugar and nucleotide sugar metabolism # Organism G6PI_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11469 PTHR11469 # PATHWAY Carbohydrate degradation; glycolysis; D-glyceraldehyde 3- phosphate and glycerone phosphate from D-glucose step 2/4. # PATRIC 32123579 VBIEscCol129921_4138 # PDB 3NBU X-ray; 2.05 A; A/B/C/D/E/F=1-549 # PIR H65209 NUEC # PRINTS PR00662 G6PISOMERASE # PROSITE PS00174 P_GLUCOSE_ISOMERASE_2 # PROSITE PS00765 P_GLUCOSE_ISOMERASE_1 # PROSITE PS51463 P_GLUCOSE_ISOMERASE_3 # Pfam PF00342 PGI # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName G6PI_ECOLI Glucose-6-phosphate isomerase # RefSeq NP_418449 NC_000913.3 # RefSeq WP_000789986 NZ_LN832404.1 # SIMILARITY Belongs to the GPI family. {ECO 0000305}. # SUBCELLULAR LOCATION G6PI_ECOLI Cytoplasm {ECO 0000269|PubMed 4344919}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 22393408}. # UniPathway UPA00109 UER00181 # eggNOG COG0166 LUCA # eggNOG ENOG4107QP8 Bacteria BLAST swissprot:G6PI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:G6PI_ECOLI BioCyc ECOL316407:JW3985-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3985-MONOMER BioCyc EcoCyc:PGLUCISOM http://biocyc.org/getid?id=EcoCyc:PGLUCISOM BioCyc MetaCyc:PGLUCISOM http://biocyc.org/getid?id=MetaCyc:PGLUCISOM COG COG0166 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0166 DIP DIP-35887N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35887N DOI 10.1007/BF00160467 http://dx.doi.org/10.1007/BF00160467 DOI 10.1007/BF00330951 http://dx.doi.org/10.1007/BF00330951 DOI 10.1007/s00203-008-0361-y http://dx.doi.org/10.1007/s00203-008-0361-y DOI 10.1016/S0168-1656(03)00170-6 http://dx.doi.org/10.1016/S0168-1656(03)00170-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.270.49.29096 http://dx.doi.org/10.1074/jbc.270.49.29096 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pone.0032498 http://dx.doi.org/10.1371/journal.pone.0032498 EC_number EC:5.3.1.9 http://www.genome.jp/dbget-bin/www_bget?EC:5.3.1.9 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X15196 http://www.ebi.ac.uk/ena/data/view/X15196 ENZYME 5.3.1.9 http://enzyme.expasy.org/EC/5.3.1.9 EchoBASE EB0696 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0696 EcoGene EG10702 http://www.ecogene.org/geneInfo.php?eg_id=EG10702 EnsemblBacteria AAC76995 http://www.ensemblgenomes.org/id/AAC76995 EnsemblBacteria AAC76995 http://www.ensemblgenomes.org/id/AAC76995 EnsemblBacteria BAE78027 http://www.ensemblgenomes.org/id/BAE78027 EnsemblBacteria BAE78027 http://www.ensemblgenomes.org/id/BAE78027 EnsemblBacteria BAE78027 http://www.ensemblgenomes.org/id/BAE78027 EnsemblBacteria b4025 http://www.ensemblgenomes.org/id/b4025 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004347 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004347 GO_process GO:0006094 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006094 GO_process GO:0006096 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006096 GO_process GO:0034599 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034599 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 1.10.1390.10 http://www.cathdb.info/version/latest/superfamily/1.10.1390.10 GeneID 948535 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948535 HAMAP MF_00473 http://hamap.expasy.org/unirule/MF_00473 HOGENOM HOG000261371 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261371&db=HOGENOM6 InParanoid P0A6T1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6T1 IntAct P0A6T1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6T1* IntEnz 5.3.1.9 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.3.1.9 InterPro IPR001672 http://www.ebi.ac.uk/interpro/entry/IPR001672 InterPro IPR018189 http://www.ebi.ac.uk/interpro/entry/IPR018189 InterPro IPR023096 http://www.ebi.ac.uk/interpro/entry/IPR023096 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3985 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3985 KEGG_Gene eco:b4025 http://www.genome.jp/dbget-bin/www_bget?eco:b4025 KEGG_Orthology KO:K01810 http://www.genome.jp/dbget-bin/www_bget?KO:K01810 KEGG_Pathway ko00010 http://www.genome.jp/kegg-bin/show_pathway?ko00010 KEGG_Pathway ko00030 http://www.genome.jp/kegg-bin/show_pathway?ko00030 KEGG_Pathway ko00500 http://www.genome.jp/kegg-bin/show_pathway?ko00500 KEGG_Pathway ko00520 http://www.genome.jp/kegg-bin/show_pathway?ko00520 KEGG_Reaction rn:R02739 http://www.genome.jp/dbget-bin/www_bget?rn:R02739 KEGG_Reaction rn:R02740 http://www.genome.jp/dbget-bin/www_bget?rn:R02740 KEGG_Reaction rn:R03321 http://www.genome.jp/dbget-bin/www_bget?rn:R03321 OMA SHLIAPY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SHLIAPY PANTHER PTHR11469 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11469 PDB 3NBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3NBU PDBsum 3NBU http://www.ebi.ac.uk/pdbsum/3NBU PRINTS PR00662 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00662 PROSITE PS00174 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00174 PROSITE PS00765 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00765 PROSITE PS51463 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51463 PSORT swissprot:G6PI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:G6PI_ECOLI PSORT-B swissprot:G6PI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:G6PI_ECOLI PSORT2 swissprot:G6PI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:G6PI_ECOLI Pfam PF00342 http://pfam.xfam.org/family/PF00342 Phobius swissprot:G6PI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:G6PI_ECOLI PhylomeDB P0A6T1 http://phylomedb.org/?seqid=P0A6T1 ProteinModelPortal P0A6T1 http://www.proteinmodelportal.org/query/uniprot/P0A6T1 PubMed 14511906 http://www.ncbi.nlm.nih.gov/pubmed/14511906 PubMed 1593646 http://www.ncbi.nlm.nih.gov/pubmed/1593646 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18368388 http://www.ncbi.nlm.nih.gov/pubmed/18368388 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 22393408 http://www.ncbi.nlm.nih.gov/pubmed/22393408 PubMed 2549364 http://www.ncbi.nlm.nih.gov/pubmed/2549364 PubMed 4344919 http://www.ncbi.nlm.nih.gov/pubmed/4344919 PubMed 7493933 http://www.ncbi.nlm.nih.gov/pubmed/7493933 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418449 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418449 RefSeq WP_000789986 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000789986 SMR P0A6T1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6T1 STRING 511145.b4025 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4025&targetmode=cogs STRING COG0166 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0166&targetmode=cogs UniProtKB G6PI_ECOLI http://www.uniprot.org/uniprot/G6PI_ECOLI UniProtKB-AC P0A6T1 http://www.uniprot.org/uniprot/P0A6T1 charge swissprot:G6PI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:G6PI_ECOLI eggNOG COG0166 http://eggnogapi.embl.de/nog_data/html/tree/COG0166 eggNOG ENOG4107QP8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QP8 epestfind swissprot:G6PI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:G6PI_ECOLI garnier swissprot:G6PI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:G6PI_ECOLI helixturnhelix swissprot:G6PI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:G6PI_ECOLI hmoment swissprot:G6PI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:G6PI_ECOLI iep swissprot:G6PI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:G6PI_ECOLI inforesidue swissprot:G6PI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:G6PI_ECOLI octanol swissprot:G6PI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:G6PI_ECOLI pepcoil swissprot:G6PI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:G6PI_ECOLI pepdigest swissprot:G6PI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:G6PI_ECOLI pepinfo swissprot:G6PI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:G6PI_ECOLI pepnet swissprot:G6PI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:G6PI_ECOLI pepstats swissprot:G6PI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:G6PI_ECOLI pepwheel swissprot:G6PI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:G6PI_ECOLI pepwindow swissprot:G6PI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:G6PI_ECOLI sigcleave swissprot:G6PI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:G6PI_ECOLI ## Database ID URL or Descriptions # BioGrid 4259805 9 # EcoGene EG13598 yahN # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015171 amino acid transmembrane transporter activity; IBA:GO_Central. # GO_process GO:0006865 amino acid transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # IntAct P75693 3 # InterPro IPR001123 LysE-type # InterPro IPR004778 Homoserine/Threonine_efflux # KEGG_Brite ko02000 Transporters # Organism YAHN_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30086 PTHR30086 # PATRIC 32115785 VBIEscCol129921_0334 # PIR H64759 H64759 # PIRSF PIRSF006324 LeuE # Pfam PF01810 LysE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAHN_ECOLI Uncharacterized membrane protein YahN # RefSeq NP_414862 NC_000913.3 # SIMILARITY Belongs to the rht family. {ECO 0000305}. # SUBCELLULAR LOCATION YAHN_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # TCDB 2.A.76.1 the resistance to homoserine/threonine (rhtb) family # TIGRFAMs TIGR00949 2A76 # eggNOG COG1280 LUCA # eggNOG ENOG4105E82 Bacteria BLAST swissprot:YAHN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAHN_ECOLI BioCyc ECOL316407:JW0320-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0320-MONOMER BioCyc EcoCyc:G6193-MONOMER http://biocyc.org/getid?id=EcoCyc:G6193-MONOMER COG COG1280 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1280 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB3367 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3367 EcoGene EG13598 http://www.ecogene.org/geneInfo.php?eg_id=EG13598 EnsemblBacteria AAC73431 http://www.ensemblgenomes.org/id/AAC73431 EnsemblBacteria AAC73431 http://www.ensemblgenomes.org/id/AAC73431 EnsemblBacteria BAE76111 http://www.ensemblgenomes.org/id/BAE76111 EnsemblBacteria BAE76111 http://www.ensemblgenomes.org/id/BAE76111 EnsemblBacteria BAE76111 http://www.ensemblgenomes.org/id/BAE76111 EnsemblBacteria b0328 http://www.ensemblgenomes.org/id/b0328 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015171 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171 GO_process GO:0006865 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 944968 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944968 HOGENOM HOG000122945 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122945&db=HOGENOM6 InParanoid P75693 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75693 IntAct P75693 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75693* InterPro IPR001123 http://www.ebi.ac.uk/interpro/entry/IPR001123 InterPro IPR004778 http://www.ebi.ac.uk/interpro/entry/IPR004778 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0320 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0320 KEGG_Gene eco:b0328 http://www.genome.jp/dbget-bin/www_bget?eco:b0328 KEGG_Orthology KO:K03329 http://www.genome.jp/dbget-bin/www_bget?KO:K03329 OMA VIWRVFL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VIWRVFL PANTHER PTHR30086 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30086 PSORT swissprot:YAHN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAHN_ECOLI PSORT-B swissprot:YAHN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAHN_ECOLI PSORT2 swissprot:YAHN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAHN_ECOLI Pfam PF01810 http://pfam.xfam.org/family/PF01810 Phobius swissprot:YAHN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAHN_ECOLI PhylomeDB P75693 http://phylomedb.org/?seqid=P75693 ProteinModelPortal P75693 http://www.proteinmodelportal.org/query/uniprot/P75693 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414862 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414862 STRING 511145.b0328 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0328&targetmode=cogs STRING COG1280 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1280&targetmode=cogs TCDB 2.A.76.1 http://www.tcdb.org/search/result.php?tc=2.A.76.1 TIGRFAMs TIGR00949 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00949 UniProtKB YAHN_ECOLI http://www.uniprot.org/uniprot/YAHN_ECOLI UniProtKB-AC P75693 http://www.uniprot.org/uniprot/P75693 charge swissprot:YAHN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAHN_ECOLI eggNOG COG1280 http://eggnogapi.embl.de/nog_data/html/tree/COG1280 eggNOG ENOG4105E82 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E82 epestfind swissprot:YAHN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAHN_ECOLI garnier swissprot:YAHN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAHN_ECOLI helixturnhelix swissprot:YAHN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAHN_ECOLI hmoment swissprot:YAHN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAHN_ECOLI iep swissprot:YAHN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAHN_ECOLI inforesidue swissprot:YAHN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAHN_ECOLI octanol swissprot:YAHN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAHN_ECOLI pepcoil swissprot:YAHN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAHN_ECOLI pepdigest swissprot:YAHN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAHN_ECOLI pepinfo swissprot:YAHN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAHN_ECOLI pepnet swissprot:YAHN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAHN_ECOLI pepstats swissprot:YAHN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAHN_ECOLI pepwheel swissprot:YAHN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAHN_ECOLI pepwindow swissprot:YAHN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAHN_ECOLI sigcleave swissprot:YAHN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAHN_ECOLI ## Database ID URL or Descriptions # CAUTION A portion of this ORF was originally annotated as mcrD, and reported to inhibit mcrE restriction. {ECO 0000305}. # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG12583 yjiV # Gene3D 3.40.50.300 -; 2. # InterPro IPR027417 P-loop_NTPase # Organism YJIV_ECOLI Escherichia coli (strain K12) # PIR A65249 A65249 # PIR S56569 S56569 # PIR S56570 S56570 # Proteomes UP000000625 Chromosome # RecName YJIV_ECOLI Putative uncharacterized protein YjiV # RefSeq WP_014639049 NZ_LN832404.1 # SEQUENCE CAUTION YJIV_ECOLI Sequence=AAA97239.1; Type=Frameshift; Positions=102, 416; Evidence={ECO 0000305}; Sequence=AAA97240.1; Type=Frameshift; Positions=102, 416; Evidence={ECO 0000305}; Sequence=AAA97241.1; Type=Frameshift; Positions=102, 416; Evidence={ECO 0000305}; Sequence=CAA39195.1; Type=Frameshift; Positions=890; Evidence={ECO 0000305}; BLAST swissprot:YJIV_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJIV_ECOLI BioCyc EcoCyc:EG11386-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11386-MONOMER DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X55662 http://www.ebi.ac.uk/ena/data/view/X55662 EchoBASE EB2469 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2469 EcoGene EG12583 http://www.ecogene.org/geneInfo.php?eg_id=EG12583 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 HOGENOM HOG000202518 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000202518&db=HOGENOM6 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 PSORT swissprot:YJIV_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJIV_ECOLI PSORT-B swissprot:YJIV_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJIV_ECOLI PSORT2 swissprot:YJIV_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJIV_ECOLI Phobius swissprot:YJIV_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJIV_ECOLI ProteinModelPortal P39393 http://www.proteinmodelportal.org/query/uniprot/P39393 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_014639049 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_014639049 SMR P39393 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39393 UniProtKB YJIV_ECOLI http://www.uniprot.org/uniprot/YJIV_ECOLI UniProtKB-AC P39393 http://www.uniprot.org/uniprot/P39393 charge swissprot:YJIV_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJIV_ECOLI epestfind swissprot:YJIV_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJIV_ECOLI garnier swissprot:YJIV_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJIV_ECOLI helixturnhelix swissprot:YJIV_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJIV_ECOLI hmoment swissprot:YJIV_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJIV_ECOLI iep swissprot:YJIV_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJIV_ECOLI inforesidue swissprot:YJIV_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJIV_ECOLI octanol swissprot:YJIV_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJIV_ECOLI pepcoil swissprot:YJIV_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJIV_ECOLI pepdigest swissprot:YJIV_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJIV_ECOLI pepinfo swissprot:YJIV_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJIV_ECOLI pepnet swissprot:YJIV_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJIV_ECOLI pepstats swissprot:YJIV_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJIV_ECOLI pepwheel swissprot:YJIV_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJIV_ECOLI pepwindow swissprot:YJIV_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJIV_ECOLI sigcleave swissprot:YJIV_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJIV_ECOLI ## Database ID URL or Descriptions # BioGrid 4261681 9 # EcoGene EG13967 ydiH # IntAct P64476 13 # InterPro IPR031830 YdiH # Organism YDIH_ECOLI Escherichia coli (strain K12) # PATRIC 32118676 VBIEscCol129921_1756 # PIR E64926 E64926 # Pfam PF15930 YdiH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDIH_ECOLI Uncharacterized protein YdiH # RefSeq NP_416200 NC_000913.3 # RefSeq WP_001296104 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAE76501.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # eggNOG ENOG410671Z Bacteria # eggNOG ENOG4112CA3 LUCA BLAST swissprot:YDIH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDIH_ECOLI BioCyc ECOL316407:JW1675-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1675-MONOMER BioCyc EcoCyc:G6911-MONOMER http://biocyc.org/getid?id=EcoCyc:G6911-MONOMER DIP DIP-47934N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47934N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3724 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3724 EcoGene EG13967 http://www.ecogene.org/geneInfo.php?eg_id=EG13967 EnsemblBacteria AAC74755 http://www.ensemblgenomes.org/id/AAC74755 EnsemblBacteria AAC74755 http://www.ensemblgenomes.org/id/AAC74755 EnsemblBacteria BAE76501 http://www.ensemblgenomes.org/id/BAE76501 EnsemblBacteria BAE76501 http://www.ensemblgenomes.org/id/BAE76501 EnsemblBacteria BAE76501 http://www.ensemblgenomes.org/id/BAE76501 EnsemblBacteria b1685 http://www.ensemblgenomes.org/id/b1685 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946194 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946194 HOGENOM HOG000120964 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120964&db=HOGENOM6 IntAct P64476 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P64476* InterPro IPR031830 http://www.ebi.ac.uk/interpro/entry/IPR031830 KEGG_Gene ecj:JW1675 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1675 KEGG_Gene eco:b1685 http://www.genome.jp/dbget-bin/www_bget?eco:b1685 PSORT swissprot:YDIH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDIH_ECOLI PSORT-B swissprot:YDIH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDIH_ECOLI PSORT2 swissprot:YDIH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDIH_ECOLI Pfam PF15930 http://pfam.xfam.org/family/PF15930 Phobius swissprot:YDIH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDIH_ECOLI ProteinModelPortal P64476 http://www.proteinmodelportal.org/query/uniprot/P64476 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416200 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416200 RefSeq WP_001296104 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001296104 SMR P64476 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P64476 STRING 511145.b1685 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1685&targetmode=cogs UniProtKB YDIH_ECOLI http://www.uniprot.org/uniprot/YDIH_ECOLI UniProtKB-AC P64476 http://www.uniprot.org/uniprot/P64476 charge swissprot:YDIH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDIH_ECOLI eggNOG ENOG410671Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG410671Z eggNOG ENOG4112CA3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4112CA3 epestfind swissprot:YDIH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDIH_ECOLI garnier swissprot:YDIH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDIH_ECOLI helixturnhelix swissprot:YDIH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDIH_ECOLI hmoment swissprot:YDIH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDIH_ECOLI iep swissprot:YDIH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDIH_ECOLI inforesidue swissprot:YDIH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDIH_ECOLI octanol swissprot:YDIH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDIH_ECOLI pepcoil swissprot:YDIH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDIH_ECOLI pepdigest swissprot:YDIH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDIH_ECOLI pepinfo swissprot:YDIH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDIH_ECOLI pepnet swissprot:YDIH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDIH_ECOLI pepstats swissprot:YDIH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDIH_ECOLI pepwheel swissprot:YDIH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDIH_ECOLI pepwindow swissprot:YDIH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDIH_ECOLI sigcleave swissprot:YDIH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDIH_ECOLI ## Database ID URL or Descriptions # BioGrid 4261765 20 # EcoGene EG13957 ydhW # INDUCTION Up-regulated by the oxygen-responsive transcription factor FNR under anaerobic conditions. Repressed in the presence of nitrate or nitrite via the two-component systems NarXL and NarPQ, respectively. {ECO:0000269|PubMed 18227264}. # IntAct P77564 11 # Organism YDHW_ECOLI Escherichia coli (strain K12) # PATRIC 32118650 VBIEscCol129921_1743 # PIR H64924 H64924 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDHW_ECOLI Uncharacterized protein YdhW # RefSeq NP_416187 NC_000913.3 # eggNOG ENOG4105JVW Bacteria # eggNOG ENOG4111TJ2 LUCA BLAST swissprot:YDHW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDHW_ECOLI BioCyc ECOL316407:JW1662-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1662-MONOMER BioCyc EcoCyc:G6900-MONOMER http://biocyc.org/getid?id=EcoCyc:G6900-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1099/mic.0.2007/012146-0 http://dx.doi.org/10.1099/mic.0.2007/012146-0 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U68703 http://www.ebi.ac.uk/ena/data/view/U68703 EchoBASE EB3715 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3715 EcoGene EG13957 http://www.ecogene.org/geneInfo.php?eg_id=EG13957 EnsemblBacteria AAC74742 http://www.ensemblgenomes.org/id/AAC74742 EnsemblBacteria AAC74742 http://www.ensemblgenomes.org/id/AAC74742 EnsemblBacteria BAE76497 http://www.ensemblgenomes.org/id/BAE76497 EnsemblBacteria BAE76497 http://www.ensemblgenomes.org/id/BAE76497 EnsemblBacteria BAE76497 http://www.ensemblgenomes.org/id/BAE76497 EnsemblBacteria b1672 http://www.ensemblgenomes.org/id/b1672 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947180 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947180 HOGENOM HOG000120953 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120953&db=HOGENOM6 IntAct P77564 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77564* KEGG_Gene ecj:JW1662 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1662 KEGG_Gene eco:b1672 http://www.genome.jp/dbget-bin/www_bget?eco:b1672 OMA GLCEWLE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GLCEWLE PSORT swissprot:YDHW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDHW_ECOLI PSORT-B swissprot:YDHW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDHW_ECOLI PSORT2 swissprot:YDHW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDHW_ECOLI Phobius swissprot:YDHW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDHW_ECOLI ProteinModelPortal P77564 http://www.proteinmodelportal.org/query/uniprot/P77564 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18227264 http://www.ncbi.nlm.nih.gov/pubmed/18227264 PubMed 9023191 http://www.ncbi.nlm.nih.gov/pubmed/9023191 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416187 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416187 STRING 511145.b1672 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1672&targetmode=cogs UniProtKB YDHW_ECOLI http://www.uniprot.org/uniprot/YDHW_ECOLI UniProtKB-AC P77564 http://www.uniprot.org/uniprot/P77564 charge swissprot:YDHW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDHW_ECOLI eggNOG ENOG4105JVW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105JVW eggNOG ENOG4111TJ2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111TJ2 epestfind swissprot:YDHW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDHW_ECOLI garnier swissprot:YDHW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDHW_ECOLI helixturnhelix swissprot:YDHW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDHW_ECOLI hmoment swissprot:YDHW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDHW_ECOLI iep swissprot:YDHW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDHW_ECOLI inforesidue swissprot:YDHW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDHW_ECOLI octanol swissprot:YDHW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDHW_ECOLI pepcoil swissprot:YDHW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDHW_ECOLI pepdigest swissprot:YDHW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDHW_ECOLI pepinfo swissprot:YDHW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDHW_ECOLI pepnet swissprot:YDHW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDHW_ECOLI pepstats swissprot:YDHW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDHW_ECOLI pepwheel swissprot:YDHW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDHW_ECOLI pepwindow swissprot:YDHW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDHW_ECOLI sigcleave swissprot:YDHW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDHW_ECOLI ## Database ID URL or Descriptions # BioGrid 4263327 9 # EcoGene EG11860 yiiG # IntAct P32151 2 # InterPro IPR024291 DUF3829 # Organism YIIG_ECOLI Escherichia coli (strain K12) # PATRIC 32123301 VBIEscCol129921_4011 # PIR S40840 S40840 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF12889 DUF3829 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIIG_ECOLI Uncharacterized protein YiiG # RefSeq NP_418332 NC_000913.3 # RefSeq WP_001295677 NZ_LN832404.1 # eggNOG ENOG4108V87 Bacteria # eggNOG ENOG4111KWK LUCA BLAST swissprot:YIIG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIIG_ECOLI BioCyc ECOL316407:JW3867-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3867-MONOMER BioCyc EcoCyc:EG11860-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11860-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1806 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1806 EcoGene EG11860 http://www.ecogene.org/geneInfo.php?eg_id=EG11860 EnsemblBacteria AAC76878 http://www.ensemblgenomes.org/id/AAC76878 EnsemblBacteria AAC76878 http://www.ensemblgenomes.org/id/AAC76878 EnsemblBacteria BAE77413 http://www.ensemblgenomes.org/id/BAE77413 EnsemblBacteria BAE77413 http://www.ensemblgenomes.org/id/BAE77413 EnsemblBacteria BAE77413 http://www.ensemblgenomes.org/id/BAE77413 EnsemblBacteria b3896 http://www.ensemblgenomes.org/id/b3896 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 948392 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948392 HOGENOM HOG000126639 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126639&db=HOGENOM6 IntAct P32151 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32151* InterPro IPR024291 http://www.ebi.ac.uk/interpro/entry/IPR024291 KEGG_Gene ecj:JW3867 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3867 KEGG_Gene eco:b3896 http://www.genome.jp/dbget-bin/www_bget?eco:b3896 OMA RVRDKTP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RVRDKTP PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YIIG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIIG_ECOLI PSORT-B swissprot:YIIG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIIG_ECOLI PSORT2 swissprot:YIIG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIIG_ECOLI Pfam PF12889 http://pfam.xfam.org/family/PF12889 Phobius swissprot:YIIG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIIG_ECOLI ProteinModelPortal P32151 http://www.proteinmodelportal.org/query/uniprot/P32151 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418332 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418332 RefSeq WP_001295677 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295677 SMR P32151 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32151 STRING 511145.b3896 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3896&targetmode=cogs UniProtKB YIIG_ECOLI http://www.uniprot.org/uniprot/YIIG_ECOLI UniProtKB-AC P32151 http://www.uniprot.org/uniprot/P32151 charge swissprot:YIIG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIIG_ECOLI eggNOG ENOG4108V87 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108V87 eggNOG ENOG4111KWK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111KWK epestfind swissprot:YIIG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIIG_ECOLI garnier swissprot:YIIG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIIG_ECOLI helixturnhelix swissprot:YIIG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIIG_ECOLI hmoment swissprot:YIIG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIIG_ECOLI iep swissprot:YIIG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIIG_ECOLI inforesidue swissprot:YIIG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIIG_ECOLI octanol swissprot:YIIG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIIG_ECOLI pepcoil swissprot:YIIG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIIG_ECOLI pepdigest swissprot:YIIG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIIG_ECOLI pepinfo swissprot:YIIG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIIG_ECOLI pepnet swissprot:YIIG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIIG_ECOLI pepstats swissprot:YIIG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIIG_ECOLI pepwheel swissprot:YIIG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIIG_ECOLI pepwindow swissprot:YIIG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIIG_ECOLI sigcleave swissprot:YIIG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIIG_ECOLI ## Database ID URL or Descriptions # AltName Menaquinone biosynthesis protein MenD {ECO:0000255|HAMAP-Rule MF_01659} # BIOPHYSICOCHEMICAL PROPERTIES MEND_ECOLI Kinetic parameters KM=53 nM for isochorismate (at 22.5 degrees Celsius and pH 7.8) {ECO 0000269|PubMed 14621995, ECO 0000269|PubMed 17760421}; KM=1.5 uM for 2-oxoglutarate (at 22.5 degrees Celsius and pH 7.8) {ECO 0000269|PubMed 14621995, ECO 0000269|PubMed 17760421}; KM=2.4 uM for thiamine diphosphate (at 22.5 degrees Celsius and pH 7.8) {ECO 0000269|PubMed 14621995, ECO 0000269|PubMed 17760421}; KM=80 uM for magnesium ions (at 22.5 degrees Celsius and pH 7.8) {ECO 0000269|PubMed 14621995, ECO 0000269|PubMed 17760421}; pH dependence Optimum pH is 7-8. {ECO 0000269|PubMed 14621995, ECO 0000269|PubMed 17760421}; # BRENDA 2.2.1 2165 # BioGrid 4260506 8 # CATALYTIC ACTIVITY MEND_ECOLI Isochorismate + 2-oxoglutarate = 5- enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO(2). {ECO 0000255|HAMAP-Rule MF_01659, ECO 0000269|PubMed 17760421}. # CAUTION MEND_ECOLI Was originally thought (PubMed 1459959, PubMed 14621995 and PubMed 16511076) to be a 2-succinyl-6-hydroxy-2,4- cyclohexadiene-1-carboxylate (SHCHC) synthase but further protein analysis clearly suggests that it is a 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) synthase. {ECO 0000305|PubMed 17760421}. # COFACTOR MEND_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_01659}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000255|HAMAP-Rule MF_01659}; # COFACTOR MEND_ECOLI Name=thiamine diphosphate; Xref=ChEBI CHEBI 58937; Evidence={ECO 0000255|HAMAP-Rule MF_01659}; Note=Binds 1 thiamine pyrophosphate per subunit. {ECO 0000255|HAMAP-Rule MF_01659}; # EcoGene EG10579 menD # FUNCTION MEND_ECOLI Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC). {ECO 0000255|HAMAP- Rule MF_01659, ECO 0000269|PubMed 17760421}. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0030145 manganese ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0030976 thiamine pyrophosphate binding; IDA:EcoCyc. # GO_function GO:0070204 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity; IDA:EcoCyc. # GO_process GO:0009234 menaquinone biosynthetic process; IMP:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.970 -; 2. # HAMAP MF_01659 MenD # INDUCTION By isopropyl-beta-D-thiogalactoside (IPTG). {ECO:0000269|PubMed 1459959}. # InterPro IPR004433 MenaQ_synth_MenD # InterPro IPR011766 TPP_enzyme-bd_C # InterPro IPR012001 Thiamin_PyroP_enz_TPP-bd_dom # InterPro IPR029061 THDP-binding # InterPro IPR032264 MenD_middle # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00130 Ubiquinone and other terpenoid-quinone biosynthesis # Organism MEND_ECOLI Escherichia coli (strain K12) # PATHWAY Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 2/7. {ECO 0000255|HAMAP-Rule:MF_01659}. # PATHWAY Quinol/quinone metabolism; menaquinone biosynthesis. {ECO:0000255|HAMAP-Rule MF_01659}. # PATRIC 32119895 VBIEscCol129921_2357 # PDB 2JLA X-ray; 2.81 A; A/B/C/D=1-556 # PDB 2JLC X-ray; 2.50 A; A/B=1-556 # PDB 3FLM X-ray; 2.70 A; A/B=1-556 # PDB 3HWW X-ray; 1.95 A; A/D=1-556 # PDB 3HWX X-ray; 2.60 A; 1/A/B/I/J/R/S/Z=1-556 # PDB 5EJ4 X-ray; 1.77 A; A/B/C/D/E/F/G/H=1-556 # PDB 5EJ5 X-ray; 2.30 A; A/B/C/D/E/F/G/H=1-556 # PDB 5EJ6 X-ray; 2.24 A; A/B/C/D/E/F/G/H=1-556 # PDB 5EJ7 X-ray; 1.56 A; A/B/C/D/E/F/G/H=1-556 # PDB 5EJ8 X-ray; 1.34 A; A/B/C/D/E/F/G/H=1-556 # PDB 5EJ9 X-ray; 1.72 A; A/B/C/D/E/F/G/H=1-556 # PDB 5EJA X-ray; 1.60 A; A/B/C/D/E/F/G/H=1-556 # PIR F64997 F64997 # PIRSF PIRSF004983 MenD # Pfam PF02775 TPP_enzyme_C # Pfam PF02776 TPP_enzyme_N # Pfam PF16582 TPP_enzyme_M_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase {ECO:0000255|HAMAP-Rule MF_01659} # RefSeq NP_416767 NC_000913.3 # RefSeq WP_001295284 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA24153.1; Type=Frameshift; Positions=370; Evidence={ECO 0000305}; # SIMILARITY Belongs to the TPP enzyme family. MenD subfamily. {ECO:0000255|HAMAP-Rule MF_01659, ECO:0000305}. # SUBUNIT MEND_ECOLI Homodimer. {ECO 0000255|HAMAP-Rule MF_01659, ECO 0000269|PubMed 14621995, ECO 0000269|PubMed 16511076}. # SUPFAM SSF52518 SSF52518; 2 # TIGRFAMs TIGR00173 menD # UniPathway UPA01057 UER00164 # eggNOG COG1165 LUCA # eggNOG ENOG4105C4A Bacteria BLAST swissprot:MEND_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MEND_ECOLI BioCyc ECOL316407:JW5374-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5374-MONOMER BioCyc EcoCyc:MEND-MONOMER http://biocyc.org/getid?id=EcoCyc:MEND-MONOMER BioCyc MetaCyc:MEND-MONOMER http://biocyc.org/getid?id=MetaCyc:MEND-MONOMER COG COG1165 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1165 DIP DIP-10185N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10185N DOI 10.1016/0378-1097(96)00173-5 http://dx.doi.org/10.1016/0378-1097(96)00173-5 DOI 10.1021/bi035224j http://dx.doi.org/10.1021/bi035224j DOI 10.1021/bi700810x http://dx.doi.org/10.1021/bi700810x DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1107/S1744309105010997 http://dx.doi.org/10.1107/S1744309105010997 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.2.1.9 {ECO:0000255|HAMAP-Rule:MF_01659} http://www.genome.jp/dbget-bin/www_bget?EC:2.2.1.9 {ECO:0000255|HAMAP-Rule:MF_01659} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L04464 http://www.ebi.ac.uk/ena/data/view/L04464 EMBL L35030 http://www.ebi.ac.uk/ena/data/view/L35030 EMBL M21787 http://www.ebi.ac.uk/ena/data/view/M21787 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U54790 http://www.ebi.ac.uk/ena/data/view/U54790 ENZYME 2.2.1.9 {ECO:0000255|HAMAP-Rule:MF_01659} http://enzyme.expasy.org/EC/2.2.1.9 {ECO:0000255|HAMAP-Rule:MF_01659} EchoBASE EB0574 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0574 EcoGene EG10579 http://www.ecogene.org/geneInfo.php?eg_id=EG10579 EnsemblBacteria AAC75324 http://www.ensemblgenomes.org/id/AAC75324 EnsemblBacteria AAC75324 http://www.ensemblgenomes.org/id/AAC75324 EnsemblBacteria BAA16089 http://www.ensemblgenomes.org/id/BAA16089 EnsemblBacteria BAA16089 http://www.ensemblgenomes.org/id/BAA16089 EnsemblBacteria BAA16089 http://www.ensemblgenomes.org/id/BAA16089 EnsemblBacteria b2264 http://www.ensemblgenomes.org/id/b2264 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_function GO:0030976 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030976 GO_function GO:0070204 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070204 GO_process GO:0009234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.970 http://www.cathdb.info/version/latest/superfamily/3.40.50.970 GeneID 946720 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946720 HAMAP MF_01659 http://hamap.expasy.org/unirule/MF_01659 HOGENOM HOG000218360 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218360&db=HOGENOM6 InParanoid P17109 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P17109 IntAct P17109 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P17109* IntEnz 2.2.1.9 {ECO:0000255|HAMAP-Rule:MF_01659} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.2.1.9 {ECO:0000255|HAMAP-Rule:MF_01659} InterPro IPR004433 http://www.ebi.ac.uk/interpro/entry/IPR004433 InterPro IPR011766 http://www.ebi.ac.uk/interpro/entry/IPR011766 InterPro IPR012001 http://www.ebi.ac.uk/interpro/entry/IPR012001 InterPro IPR029061 http://www.ebi.ac.uk/interpro/entry/IPR029061 InterPro IPR032264 http://www.ebi.ac.uk/interpro/entry/IPR032264 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5374 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5374 KEGG_Gene eco:b2264 http://www.genome.jp/dbget-bin/www_bget?eco:b2264 KEGG_Orthology KO:K02551 http://www.genome.jp/dbget-bin/www_bget?KO:K02551 KEGG_Pathway ko00130 http://www.genome.jp/kegg-bin/show_pathway?ko00130 KEGG_Reaction rn:R08165 http://www.genome.jp/dbget-bin/www_bget?rn:R08165 MINT MINT-1246688 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1246688 OMA IFRILPG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IFRILPG PDB 2JLA http://www.ebi.ac.uk/pdbe-srv/view/entry/2JLA PDB 2JLC http://www.ebi.ac.uk/pdbe-srv/view/entry/2JLC PDB 3FLM http://www.ebi.ac.uk/pdbe-srv/view/entry/3FLM PDB 3HWW http://www.ebi.ac.uk/pdbe-srv/view/entry/3HWW PDB 3HWX http://www.ebi.ac.uk/pdbe-srv/view/entry/3HWX PDB 5EJ4 http://www.ebi.ac.uk/pdbe-srv/view/entry/5EJ4 PDB 5EJ5 http://www.ebi.ac.uk/pdbe-srv/view/entry/5EJ5 PDB 5EJ6 http://www.ebi.ac.uk/pdbe-srv/view/entry/5EJ6 PDB 5EJ7 http://www.ebi.ac.uk/pdbe-srv/view/entry/5EJ7 PDB 5EJ8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5EJ8 PDB 5EJ9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5EJ9 PDB 5EJA http://www.ebi.ac.uk/pdbe-srv/view/entry/5EJA PDBsum 2JLA http://www.ebi.ac.uk/pdbsum/2JLA PDBsum 2JLC http://www.ebi.ac.uk/pdbsum/2JLC PDBsum 3FLM http://www.ebi.ac.uk/pdbsum/3FLM PDBsum 3HWW http://www.ebi.ac.uk/pdbsum/3HWW PDBsum 3HWX http://www.ebi.ac.uk/pdbsum/3HWX PDBsum 5EJ4 http://www.ebi.ac.uk/pdbsum/5EJ4 PDBsum 5EJ5 http://www.ebi.ac.uk/pdbsum/5EJ5 PDBsum 5EJ6 http://www.ebi.ac.uk/pdbsum/5EJ6 PDBsum 5EJ7 http://www.ebi.ac.uk/pdbsum/5EJ7 PDBsum 5EJ8 http://www.ebi.ac.uk/pdbsum/5EJ8 PDBsum 5EJ9 http://www.ebi.ac.uk/pdbsum/5EJ9 PDBsum 5EJA http://www.ebi.ac.uk/pdbsum/5EJA PSORT swissprot:MEND_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MEND_ECOLI PSORT-B swissprot:MEND_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MEND_ECOLI PSORT2 swissprot:MEND_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MEND_ECOLI Pfam PF02775 http://pfam.xfam.org/family/PF02775 Pfam PF02776 http://pfam.xfam.org/family/PF02776 Pfam PF16582 http://pfam.xfam.org/family/PF16582 Phobius swissprot:MEND_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MEND_ECOLI PhylomeDB P17109 http://phylomedb.org/?seqid=P17109 ProteinModelPortal P17109 http://www.proteinmodelportal.org/query/uniprot/P17109 PubMed 1459959 http://www.ncbi.nlm.nih.gov/pubmed/1459959 PubMed 14621995 http://www.ncbi.nlm.nih.gov/pubmed/14621995 PubMed 16511076 http://www.ncbi.nlm.nih.gov/pubmed/16511076 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17760421 http://www.ncbi.nlm.nih.gov/pubmed/17760421 PubMed 2666397 http://www.ncbi.nlm.nih.gov/pubmed/2666397 PubMed 8764478 http://www.ncbi.nlm.nih.gov/pubmed/8764478 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416767 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416767 RefSeq WP_001295284 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295284 SMR P17109 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P17109 STRING 511145.b2264 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2264&targetmode=cogs STRING COG1165 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1165&targetmode=cogs SUPFAM SSF52518 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52518 TIGRFAMs TIGR00173 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00173 UniProtKB MEND_ECOLI http://www.uniprot.org/uniprot/MEND_ECOLI UniProtKB-AC P17109 http://www.uniprot.org/uniprot/P17109 charge swissprot:MEND_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MEND_ECOLI eggNOG COG1165 http://eggnogapi.embl.de/nog_data/html/tree/COG1165 eggNOG ENOG4105C4A http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C4A epestfind swissprot:MEND_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MEND_ECOLI garnier swissprot:MEND_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MEND_ECOLI helixturnhelix swissprot:MEND_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MEND_ECOLI hmoment swissprot:MEND_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MEND_ECOLI iep swissprot:MEND_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MEND_ECOLI inforesidue swissprot:MEND_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MEND_ECOLI octanol swissprot:MEND_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MEND_ECOLI pepcoil swissprot:MEND_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MEND_ECOLI pepdigest swissprot:MEND_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MEND_ECOLI pepinfo swissprot:MEND_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MEND_ECOLI pepnet swissprot:MEND_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MEND_ECOLI pepstats swissprot:MEND_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MEND_ECOLI pepwheel swissprot:MEND_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MEND_ECOLI pepwindow swissprot:MEND_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MEND_ECOLI sigcleave swissprot:MEND_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MEND_ECOLI ## Database ID URL or Descriptions # BioGrid 4261724 9 # EcoGene EG12101 feoA # FUNCTION FEOA_ECOLI Not known. Involved in Fe(2+) ion uptake. # GO_function GO:0046914 transition metal ion binding; IEA:InterPro. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0055072 iron ion homeostasis; IEA:UniProtKB-KW. # GO_process GO:0070627 ferrous iron import; IMP:EcoCyc. # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # GOslim_process GO:0006950 response to stress # GOslim_process GO:0042592 homeostatic process # INDUCTION Induced by hydroxyurea. {ECO:0000269|PubMed 20005847}. # IntAct P0AEL3 4 # InterPro IPR007167 Fe-transptr_FeoA # InterPro IPR008988 Transcriptional_repressor_C # KEGG_Brite ko02000 Transporters # Organism FEOA_ECOLI Escherichia coli (strain K12) # PATRIC 32122252 VBIEscCol129921_3503 # PDB 2GCX NMR; -; A=1-73 # PDB 2LX9 NMR; -; A=1-75 # PIR B36932 B36932 # Pfam PF04023 FeoA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FEOA_ECOLI Ferrous iron transport protein A # RefSeq NP_417867 NC_000913.3 # RefSeq WP_001200455 NZ_LN832404.1 # SMART SM00899 FeoA # SUPFAM SSF50037 SSF50037 # TCDB 9.A.8.1 the ferrous iron uptake (feob) family # eggNOG COG1918 LUCA # eggNOG ENOG4105XFK Bacteria BLAST swissprot:FEOA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FEOA_ECOLI BioCyc ECOL316407:JW3371-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3371-MONOMER BioCyc EcoCyc:EG12101-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12101-MONOMER COG COG1918 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1918 DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X71063 http://www.ebi.ac.uk/ena/data/view/X71063 EchoBASE EB2025 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2025 EcoGene EG12101 http://www.ecogene.org/geneInfo.php?eg_id=EG12101 EnsemblBacteria AAC76433 http://www.ensemblgenomes.org/id/AAC76433 EnsemblBacteria AAC76433 http://www.ensemblgenomes.org/id/AAC76433 EnsemblBacteria BAE77883 http://www.ensemblgenomes.org/id/BAE77883 EnsemblBacteria BAE77883 http://www.ensemblgenomes.org/id/BAE77883 EnsemblBacteria BAE77883 http://www.ensemblgenomes.org/id/BAE77883 EnsemblBacteria b3408 http://www.ensemblgenomes.org/id/b3408 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0046914 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046914 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0055072 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055072 GO_process GO:0070627 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070627 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GeneID 947909 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947909 HOGENOM HOG000053908 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000053908&db=HOGENOM6 InParanoid P0AEL3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEL3 IntAct P0AEL3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEL3* InterPro IPR007167 http://www.ebi.ac.uk/interpro/entry/IPR007167 InterPro IPR008988 http://www.ebi.ac.uk/interpro/entry/IPR008988 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3371 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3371 KEGG_Gene eco:b3408 http://www.genome.jp/dbget-bin/www_bget?eco:b3408 KEGG_Orthology KO:K04758 http://www.genome.jp/dbget-bin/www_bget?KO:K04758 OMA IETRRVN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IETRRVN PDB 2GCX http://www.ebi.ac.uk/pdbe-srv/view/entry/2GCX PDB 2LX9 http://www.ebi.ac.uk/pdbe-srv/view/entry/2LX9 PDBsum 2GCX http://www.ebi.ac.uk/pdbsum/2GCX PDBsum 2LX9 http://www.ebi.ac.uk/pdbsum/2LX9 PSORT swissprot:FEOA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FEOA_ECOLI PSORT-B swissprot:FEOA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FEOA_ECOLI PSORT2 swissprot:FEOA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FEOA_ECOLI Pfam PF04023 http://pfam.xfam.org/family/PF04023 Phobius swissprot:FEOA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FEOA_ECOLI PhylomeDB P0AEL3 http://phylomedb.org/?seqid=P0AEL3 ProteinModelPortal P0AEL3 http://www.proteinmodelportal.org/query/uniprot/P0AEL3 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 8407793 http://www.ncbi.nlm.nih.gov/pubmed/8407793 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417867 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417867 RefSeq WP_001200455 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001200455 SMART SM00899 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00899 SMR P0AEL3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEL3 STRING 511145.b3408 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3408&targetmode=cogs STRING COG1918 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1918&targetmode=cogs SUPFAM SSF50037 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50037 TCDB 9.A.8.1 http://www.tcdb.org/search/result.php?tc=9.A.8.1 UniProtKB FEOA_ECOLI http://www.uniprot.org/uniprot/FEOA_ECOLI UniProtKB-AC P0AEL3 http://www.uniprot.org/uniprot/P0AEL3 charge swissprot:FEOA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FEOA_ECOLI eggNOG COG1918 http://eggnogapi.embl.de/nog_data/html/tree/COG1918 eggNOG ENOG4105XFK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105XFK epestfind swissprot:FEOA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FEOA_ECOLI garnier swissprot:FEOA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FEOA_ECOLI helixturnhelix swissprot:FEOA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FEOA_ECOLI hmoment swissprot:FEOA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FEOA_ECOLI iep swissprot:FEOA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FEOA_ECOLI inforesidue swissprot:FEOA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FEOA_ECOLI octanol swissprot:FEOA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FEOA_ECOLI pepcoil swissprot:FEOA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FEOA_ECOLI pepdigest swissprot:FEOA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FEOA_ECOLI pepinfo swissprot:FEOA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FEOA_ECOLI pepnet swissprot:FEOA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FEOA_ECOLI pepstats swissprot:FEOA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FEOA_ECOLI pepwheel swissprot:FEOA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FEOA_ECOLI pepwindow swissprot:FEOA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FEOA_ECOLI sigcleave swissprot:FEOA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FEOA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262119 9 # EcoGene EG13405 yecM # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # Gene3D 3.10.180.10 -; 1. # InterPro IPR010393 DUF991 # InterPro IPR029068 Glyas_Bleomycin-R_OHBP_Dase # Organism YECM_ECOLI Escherichia coli (strain K12) # PATRIC 32119075 VBIEscCol129921_1955 # PDB 1K4N X-ray; 1.60 A; A=1-188 # PIR C64950 C64950 # Pfam PF06185 YecM # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YECM_ECOLI Protein YecM # RefSeq NP_416389 NC_000913.3 # RefSeq WP_001326725 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA89200.1; Type=Frameshift; Positions=126; Evidence={ECO:0000305}; Sequence=AAA89201.1; Type=Frameshift; Positions=128; Note=Produces two separate ORFs.; Evidence={ECO 0000305}; # SIMILARITY To H.influenzae HI_1582/HI_1581. {ECO 0000305}. # SUPFAM SSF54593 SSF54593 # eggNOG COG3102 LUCA # eggNOG ENOG4106ZCM Bacteria BLAST swissprot:YECM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YECM_ECOLI BioCyc ECOL316407:JW5309-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5309-MONOMER BioCyc EcoCyc:G7025-MONOMER http://biocyc.org/getid?id=EcoCyc:G7025-MONOMER COG COG3102 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3102 DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L38618 http://www.ebi.ac.uk/ena/data/view/L38618 EMBL L38618 http://www.ebi.ac.uk/ena/data/view/L38618 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3181 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3181 EcoGene EG13405 http://www.ecogene.org/geneInfo.php?eg_id=EG13405 EnsemblBacteria AAC74945 http://www.ensemblgenomes.org/id/AAC74945 EnsemblBacteria AAC74945 http://www.ensemblgenomes.org/id/AAC74945 EnsemblBacteria BAA15685 http://www.ensemblgenomes.org/id/BAA15685 EnsemblBacteria BAA15685 http://www.ensemblgenomes.org/id/BAA15685 EnsemblBacteria BAA15685 http://www.ensemblgenomes.org/id/BAA15685 EnsemblBacteria b1875 http://www.ensemblgenomes.org/id/b1875 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 Gene3D 3.10.180.10 http://www.cathdb.info/version/latest/superfamily/3.10.180.10 GeneID 946415 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946415 HOGENOM HOG000293172 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000293172&db=HOGENOM6 InParanoid P52007 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P52007 InterPro IPR010393 http://www.ebi.ac.uk/interpro/entry/IPR010393 InterPro IPR029068 http://www.ebi.ac.uk/interpro/entry/IPR029068 KEGG_Gene ecj:JW5309 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5309 KEGG_Gene eco:b1875 http://www.genome.jp/dbget-bin/www_bget?eco:b1875 KEGG_Orthology KO:K09907 http://www.genome.jp/dbget-bin/www_bget?KO:K09907 OMA VEGWEHI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VEGWEHI PDB 1K4N http://www.ebi.ac.uk/pdbe-srv/view/entry/1K4N PDBsum 1K4N http://www.ebi.ac.uk/pdbsum/1K4N PSORT swissprot:YECM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YECM_ECOLI PSORT-B swissprot:YECM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YECM_ECOLI PSORT2 swissprot:YECM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YECM_ECOLI Pfam PF06185 http://pfam.xfam.org/family/PF06185 Phobius swissprot:YECM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YECM_ECOLI ProteinModelPortal P52007 http://www.proteinmodelportal.org/query/uniprot/P52007 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416389 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416389 RefSeq WP_001326725 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001326725 SMR P52007 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P52007 STRING 511145.b1875 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1875&targetmode=cogs STRING COG3102 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3102&targetmode=cogs SUPFAM SSF54593 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54593 UniProtKB YECM_ECOLI http://www.uniprot.org/uniprot/YECM_ECOLI UniProtKB-AC P52007 http://www.uniprot.org/uniprot/P52007 charge swissprot:YECM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YECM_ECOLI eggNOG COG3102 http://eggnogapi.embl.de/nog_data/html/tree/COG3102 eggNOG ENOG4106ZCM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106ZCM epestfind swissprot:YECM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YECM_ECOLI garnier swissprot:YECM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YECM_ECOLI helixturnhelix swissprot:YECM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YECM_ECOLI hmoment swissprot:YECM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YECM_ECOLI iep swissprot:YECM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YECM_ECOLI inforesidue swissprot:YECM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YECM_ECOLI octanol swissprot:YECM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YECM_ECOLI pepcoil swissprot:YECM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YECM_ECOLI pepdigest swissprot:YECM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YECM_ECOLI pepinfo swissprot:YECM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YECM_ECOLI pepnet swissprot:YECM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YECM_ECOLI pepstats swissprot:YECM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YECM_ECOLI pepwheel swissprot:YECM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YECM_ECOLI pepwindow swissprot:YECM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YECM_ECOLI sigcleave swissprot:YECM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YECM_ECOLI ## Database ID URL or Descriptions # BioGrid 4263042 4 # EcoGene EG11089 yacC # InterPro IPR019114 Chap_lipoprot_PulS/OutS-like # Organism YACC_ECOLI Escherichia coli (strain K12) # PATRIC 32115345 VBIEscCol129921_0124 # Pfam PF09691 T2SS_PulS_OutS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YACC_ECOLI Uncharacterized protein YacC # RefSeq NP_414664 NC_000913.3 # RefSeq WP_001295568 NZ_LN832404.1 # TCDB 8.A.2.1 the secretin auxiliary lipoprotein (sal) family # eggNOG ENOG4108ZRK Bacteria # eggNOG ENOG4111NGC LUCA BLAST swissprot:YACC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YACC_ECOLI BioCyc ECOL316407:JW0118-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0118-MONOMER BioCyc EcoCyc:EG11089-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11089-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J02804 http://www.ebi.ac.uk/ena/data/view/J02804 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1081 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1081 EcoGene EG11089 http://www.ecogene.org/geneInfo.php?eg_id=EG11089 EnsemblBacteria AAC73233 http://www.ensemblgenomes.org/id/AAC73233 EnsemblBacteria AAC73233 http://www.ensemblgenomes.org/id/AAC73233 EnsemblBacteria BAB96696 http://www.ensemblgenomes.org/id/BAB96696 EnsemblBacteria BAB96696 http://www.ensemblgenomes.org/id/BAB96696 EnsemblBacteria BAB96696 http://www.ensemblgenomes.org/id/BAB96696 EnsemblBacteria b0122 http://www.ensemblgenomes.org/id/b0122 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 948472 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948472 HOGENOM HOG000116832 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000116832&db=HOGENOM6 IntAct P0AA95 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AA95* InterPro IPR019114 http://www.ebi.ac.uk/interpro/entry/IPR019114 KEGG_Gene ecj:JW0118 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0118 KEGG_Gene eco:b0122 http://www.genome.jp/dbget-bin/www_bget?eco:b0122 OMA NYDSFDM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NYDSFDM PSORT swissprot:YACC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YACC_ECOLI PSORT-B swissprot:YACC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YACC_ECOLI PSORT2 swissprot:YACC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YACC_ECOLI Pfam PF09691 http://pfam.xfam.org/family/PF09691 Phobius swissprot:YACC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YACC_ECOLI ProteinModelPortal P0AA95 http://www.proteinmodelportal.org/query/uniprot/P0AA95 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2666401 http://www.ncbi.nlm.nih.gov/pubmed/2666401 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414664 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414664 RefSeq WP_001295568 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295568 STRING 511145.b0122 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0122&targetmode=cogs TCDB 8.A.2.1 http://www.tcdb.org/search/result.php?tc=8.A.2.1 UniProtKB YACC_ECOLI http://www.uniprot.org/uniprot/YACC_ECOLI UniProtKB-AC P0AA95 http://www.uniprot.org/uniprot/P0AA95 charge swissprot:YACC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YACC_ECOLI eggNOG ENOG4108ZRK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZRK eggNOG ENOG4111NGC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111NGC epestfind swissprot:YACC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YACC_ECOLI garnier swissprot:YACC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YACC_ECOLI helixturnhelix swissprot:YACC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YACC_ECOLI hmoment swissprot:YACC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YACC_ECOLI iep swissprot:YACC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YACC_ECOLI inforesidue swissprot:YACC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YACC_ECOLI octanol swissprot:YACC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YACC_ECOLI pepcoil swissprot:YACC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YACC_ECOLI pepdigest swissprot:YACC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YACC_ECOLI pepinfo swissprot:YACC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YACC_ECOLI pepnet swissprot:YACC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YACC_ECOLI pepstats swissprot:YACC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YACC_ECOLI pepwheel swissprot:YACC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YACC_ECOLI pepwindow swissprot:YACC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YACC_ECOLI sigcleave swissprot:YACC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YACC_ECOLI ## Database ID URL or Descriptions # BioGrid 4263159 120 # EcoGene EG13078 yqfB # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # HAMAP MF_00684 UPF0267 # InterPro IPR007374 ASCH_domain # InterPro IPR008314 UCP029143 # InterPro IPR015947 PUA-like_domain # Organism YQFB_ECOLI Escherichia coli (strain K12) # PATRIC 32121214 VBIEscCol129921_2995 # PDB 1TE7 NMR; -; A=1-103 # PIR D65074 D65074 # PIRSF PIRSF029143 UCP029143 # Pfam PF04266 ASCH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQFB_ECOLI UPF0267 protein YqfB # RefSeq NP_417376 NC_000913.3 # RefSeq WP_001182957 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0267 family. {ECO 0000305}. # SMART SM01022 ASCH # SUPFAM SSF88697 SSF88697 # eggNOG COG3097 LUCA # eggNOG ENOG4105N5Z Bacteria BLAST swissprot:YQFB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQFB_ECOLI BioCyc ECOL316407:JW2868-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2868-MONOMER BioCyc EcoCyc:G7513-MONOMER http://biocyc.org/getid?id=EcoCyc:G7513-MONOMER COG COG3097 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3097 DOI 10.1021/ja0501870 http://dx.doi.org/10.1021/ja0501870 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 EchoBASE EB2888 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2888 EcoGene EG13078 http://www.ecogene.org/geneInfo.php?eg_id=EG13078 EnsemblBacteria AAC75938 http://www.ensemblgenomes.org/id/AAC75938 EnsemblBacteria AAC75938 http://www.ensemblgenomes.org/id/AAC75938 EnsemblBacteria BAE76965 http://www.ensemblgenomes.org/id/BAE76965 EnsemblBacteria BAE76965 http://www.ensemblgenomes.org/id/BAE76965 EnsemblBacteria BAE76965 http://www.ensemblgenomes.org/id/BAE76965 EnsemblBacteria b2900 http://www.ensemblgenomes.org/id/b2900 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GeneID 947380 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947380 HAMAP MF_00684 http://hamap.expasy.org/unirule/MF_00684 HOGENOM HOG000281301 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000281301&db=HOGENOM6 InParanoid P67603 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P67603 IntAct P67603 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P67603* InterPro IPR007374 http://www.ebi.ac.uk/interpro/entry/IPR007374 InterPro IPR008314 http://www.ebi.ac.uk/interpro/entry/IPR008314 InterPro IPR015947 http://www.ebi.ac.uk/interpro/entry/IPR015947 KEGG_Gene ecj:JW2868 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2868 KEGG_Gene eco:b2900 http://www.genome.jp/dbget-bin/www_bget?eco:b2900 KEGG_Orthology KO:K09900 http://www.genome.jp/dbget-bin/www_bget?KO:K09900 OMA HARQENM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HARQENM PDB 1TE7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1TE7 PDBsum 1TE7 http://www.ebi.ac.uk/pdbsum/1TE7 PSORT swissprot:YQFB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQFB_ECOLI PSORT-B swissprot:YQFB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQFB_ECOLI PSORT2 swissprot:YQFB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQFB_ECOLI Pfam PF04266 http://pfam.xfam.org/family/PF04266 Phobius swissprot:YQFB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQFB_ECOLI ProteinModelPortal P67603 http://www.proteinmodelportal.org/query/uniprot/P67603 PubMed 15969587 http://www.ncbi.nlm.nih.gov/pubmed/15969587 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417376 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417376 RefSeq WP_001182957 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001182957 SMART SM01022 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01022 SMR P67603 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P67603 STRING 511145.b2900 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2900&targetmode=cogs STRING COG3097 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3097&targetmode=cogs SUPFAM SSF88697 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF88697 UniProtKB YQFB_ECOLI http://www.uniprot.org/uniprot/YQFB_ECOLI UniProtKB-AC P67603 http://www.uniprot.org/uniprot/P67603 charge swissprot:YQFB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQFB_ECOLI eggNOG COG3097 http://eggnogapi.embl.de/nog_data/html/tree/COG3097 eggNOG ENOG4105N5Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105N5Z epestfind swissprot:YQFB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQFB_ECOLI garnier swissprot:YQFB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQFB_ECOLI helixturnhelix swissprot:YQFB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQFB_ECOLI hmoment swissprot:YQFB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQFB_ECOLI iep swissprot:YQFB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQFB_ECOLI inforesidue swissprot:YQFB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQFB_ECOLI octanol swissprot:YQFB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQFB_ECOLI pepcoil swissprot:YQFB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQFB_ECOLI pepdigest swissprot:YQFB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQFB_ECOLI pepinfo swissprot:YQFB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQFB_ECOLI pepnet swissprot:YQFB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQFB_ECOLI pepstats swissprot:YQFB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQFB_ECOLI pepwheel swissprot:YQFB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQFB_ECOLI pepwindow swissprot:YQFB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQFB_ECOLI sigcleave swissprot:YQFB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQFB_ECOLI ## Database ID URL or Descriptions # BioGrid 4263501 6 # EcoGene EG14032 yecN # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # Gene3D 1.20.120.550 -; 1. # InterPro IPR001129 Membr-assoc_MAPEG # InterPro IPR023352 MAPEG-like_dom # Organism YECN_ECOLI Escherichia coli (strain K12) # PATRIC 32119061 VBIEscCol129921_1948 # Pfam PF01124 MAPEG # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YECN_ECOLI Inner membrane protein YecN # RefSeq NP_416383 NC_000913.3 # RefSeq WP_000252980 NZ_LN832404.1 # SUBCELLULAR LOCATION YECN_ECOLI Cell inner membrane; Single-pass membrane protein. # eggNOG COG3788 LUCA # eggNOG ENOG4105WJG Bacteria BLAST swissprot:YECN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YECN_ECOLI BioCyc ECOL316407:JW5308-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5308-MONOMER BioCyc EcoCyc:G7019-MONOMER http://biocyc.org/getid?id=EcoCyc:G7019-MONOMER COG COG3788 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3788 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3786 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3786 EcoGene EG14032 http://www.ecogene.org/geneInfo.php?eg_id=EG14032 EnsemblBacteria AAC74939 http://www.ensemblgenomes.org/id/AAC74939 EnsemblBacteria AAC74939 http://www.ensemblgenomes.org/id/AAC74939 EnsemblBacteria BAE76548 http://www.ensemblgenomes.org/id/BAE76548 EnsemblBacteria BAE76548 http://www.ensemblgenomes.org/id/BAE76548 EnsemblBacteria BAE76548 http://www.ensemblgenomes.org/id/BAE76548 EnsemblBacteria b1869 http://www.ensemblgenomes.org/id/b1869 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 Gene3D 1.20.120.550 http://www.cathdb.info/version/latest/superfamily/1.20.120.550 GeneID 946381 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946381 HOGENOM HOG000278664 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278664&db=HOGENOM6 InParanoid P64515 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P64515 InterPro IPR001129 http://www.ebi.ac.uk/interpro/entry/IPR001129 InterPro IPR023352 http://www.ebi.ac.uk/interpro/entry/IPR023352 KEGG_Gene ecj:JW5308 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5308 KEGG_Gene eco:b1869 http://www.genome.jp/dbget-bin/www_bget?eco:b1869 KEGG_Orthology KO:K07136 http://www.genome.jp/dbget-bin/www_bget?KO:K07136 OMA LRTQYRV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LRTQYRV PSORT swissprot:YECN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YECN_ECOLI PSORT-B swissprot:YECN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YECN_ECOLI PSORT2 swissprot:YECN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YECN_ECOLI Pfam PF01124 http://pfam.xfam.org/family/PF01124 Phobius swissprot:YECN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YECN_ECOLI ProteinModelPortal P64515 http://www.proteinmodelportal.org/query/uniprot/P64515 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416383 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416383 RefSeq WP_000252980 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000252980 SMR P64515 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P64515 STRING 511145.b1869 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1869&targetmode=cogs STRING COG3788 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3788&targetmode=cogs UniProtKB YECN_ECOLI http://www.uniprot.org/uniprot/YECN_ECOLI UniProtKB-AC P64515 http://www.uniprot.org/uniprot/P64515 charge swissprot:YECN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YECN_ECOLI eggNOG COG3788 http://eggnogapi.embl.de/nog_data/html/tree/COG3788 eggNOG ENOG4105WJG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105WJG epestfind swissprot:YECN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YECN_ECOLI garnier swissprot:YECN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YECN_ECOLI helixturnhelix swissprot:YECN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YECN_ECOLI hmoment swissprot:YECN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YECN_ECOLI iep swissprot:YECN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YECN_ECOLI inforesidue swissprot:YECN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YECN_ECOLI octanol swissprot:YECN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YECN_ECOLI pepcoil swissprot:YECN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YECN_ECOLI pepdigest swissprot:YECN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YECN_ECOLI pepinfo swissprot:YECN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YECN_ECOLI pepnet swissprot:YECN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YECN_ECOLI pepstats swissprot:YECN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YECN_ECOLI pepwheel swissprot:YECN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YECN_ECOLI pepwindow swissprot:YECN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YECN_ECOLI sigcleave swissprot:YECN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YECN_ECOLI ## Database ID URL or Descriptions # BioGrid 4263332 4 # EcoGene EG10503 ilvY # FUNCTION ILVY_ECOLI This protein activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate. IlvY is also a negative regulator of its own expression. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0008652 cellular amino acid biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0009082 branched-chain amino acid biosynthetic process; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # IntAct P05827 4 # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR005119 LysR_subst-bd # InterPro IPR011991 WHTH_DNA-bd_dom # KEGG_Brite ko03000 Transcription factors # Organism ILVY_ECOLI Escherichia coli (strain K12) # PATRIC 32123041 VBIEscCol129921_3890 # PIR B26287 RGECIY # PRINTS PR00039 HTHLYSR # PROSITE PS50931 HTH_LYSR # Pfam PF00126 HTH_1 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ILVY_ECOLI HTH-type transcriptional regulator IlvY # RefSeq NP_418221 NC_000913.3 # RefSeq WP_000365791 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lysR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00253}. # SUBCELLULAR LOCATION ILVY_ECOLI Cytoplasm. # SUPFAM SSF46785 SSF46785 # eggNOG COG0583 LUCA # eggNOG ENOG4105EMY Bacteria BLAST swissprot:ILVY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ILVY_ECOLI BioCyc ECOL316407:JW3746-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3746-MONOMER BioCyc EcoCyc:PD00200 http://biocyc.org/getid?id=EcoCyc:PD00200 COG COG0583 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0583 DIP DIP-10028N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10028N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/15.5.2137 http://dx.doi.org/10.1093/nar/15.5.2137 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M11689 http://www.ebi.ac.uk/ena/data/view/M11689 EMBL M32253 http://www.ebi.ac.uk/ena/data/view/M32253 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0498 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0498 EcoGene EG10503 http://www.ecogene.org/geneInfo.php?eg_id=EG10503 EnsemblBacteria AAC77493 http://www.ensemblgenomes.org/id/AAC77493 EnsemblBacteria AAC77493 http://www.ensemblgenomes.org/id/AAC77493 EnsemblBacteria BAE77524 http://www.ensemblgenomes.org/id/BAE77524 EnsemblBacteria BAE77524 http://www.ensemblgenomes.org/id/BAE77524 EnsemblBacteria BAE77524 http://www.ensemblgenomes.org/id/BAE77524 EnsemblBacteria b3773 http://www.ensemblgenomes.org/id/b3773 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0008652 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008652 GO_process GO:0009082 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009082 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 948284 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948284 HOGENOM HOG000269751 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000269751&db=HOGENOM6 InParanoid P05827 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P05827 IntAct P05827 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P05827* InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW3746 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3746 KEGG_Gene eco:b3773 http://www.genome.jp/dbget-bin/www_bget?eco:b3773 KEGG_Orthology KO:K02521 http://www.genome.jp/dbget-bin/www_bget?KO:K02521 OMA TAKAMHI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TAKAMHI PRINTS PR00039 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00039 PROSITE PS50931 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50931 PSORT swissprot:ILVY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ILVY_ECOLI PSORT-B swissprot:ILVY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ILVY_ECOLI PSORT2 swissprot:ILVY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ILVY_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:ILVY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ILVY_ECOLI PhylomeDB P05827 http://phylomedb.org/?seqid=P05827 ProteinModelPortal P05827 http://www.proteinmodelportal.org/query/uniprot/P05827 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3003115 http://www.ncbi.nlm.nih.gov/pubmed/3003115 PubMed 3550695 http://www.ncbi.nlm.nih.gov/pubmed/3550695 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418221 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418221 RefSeq WP_000365791 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000365791 SMR P05827 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P05827 STRING 511145.b3773 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3773&targetmode=cogs STRING COG0583 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0583&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB ILVY_ECOLI http://www.uniprot.org/uniprot/ILVY_ECOLI UniProtKB-AC P05827 http://www.uniprot.org/uniprot/P05827 charge swissprot:ILVY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ILVY_ECOLI eggNOG COG0583 http://eggnogapi.embl.de/nog_data/html/tree/COG0583 eggNOG ENOG4105EMY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EMY epestfind swissprot:ILVY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ILVY_ECOLI garnier swissprot:ILVY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ILVY_ECOLI helixturnhelix swissprot:ILVY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ILVY_ECOLI hmoment swissprot:ILVY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ILVY_ECOLI iep swissprot:ILVY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ILVY_ECOLI inforesidue swissprot:ILVY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ILVY_ECOLI octanol swissprot:ILVY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ILVY_ECOLI pepcoil swissprot:ILVY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ILVY_ECOLI pepdigest swissprot:ILVY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ILVY_ECOLI pepinfo swissprot:ILVY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ILVY_ECOLI pepnet swissprot:ILVY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ILVY_ECOLI pepstats swissprot:ILVY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ILVY_ECOLI pepwheel swissprot:ILVY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ILVY_ECOLI pepwindow swissprot:ILVY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ILVY_ECOLI sigcleave swissprot:ILVY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ILVY_ECOLI ## Database ID URL or Descriptions # AltName GMM_ECOLI Colanic acid biosynthesis protein WcaH # BIOPHYSICOCHEMICAL PROPERTIES GMM_ECOLI Kinetic parameters KM=0.3 mM for GDP-mannose {ECO 0000269|PubMed 7592609}; KM=1.9 mM for GDP-glucose {ECO 0000269|PubMed 7592609}; Vmax=1.6 umol/min/mg enzyme with GDP-mannose as substrate {ECO 0000269|PubMed 7592609}; Vmax=7.5 umol/min/mg enzyme with GDP-glucose as substrate {ECO 0000269|PubMed 7592609}; Note=GDP-alpha-D-mannose is likely to be the biological substrate, but the Kcat/KM obtained with GDP-alpha-D-glucose is very similar to that with GDP-alpha-D-mannose.; pH dependence Optimum pH is 9.3. {ECO 0000269|PubMed 7592609}; # BioGrid 4261145 369 # CATALYTIC ACTIVITY GMM_ECOLI GDP-D-mannose + H(2)O = GDP + D-mannose. {ECO 0000255|HAMAP-Rule MF_00941, ECO 0000269|PubMed 10913267, ECO 0000269|PubMed 7592609}. # CDD cd03430 GDPMH # COFACTOR GMM_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_00941, ECO 0000269|PubMed 10913267, ECO 0000269|PubMed 12196023, ECO 0000269|PubMed 15274914}; Note=Binds 1 Mg(2+) ion per subunit. {ECO 0000255|HAMAP- Rule MF_00941, ECO 0000269|PubMed 10913267, ECO 0000269|PubMed 12196023, ECO 0000269|PubMed 15274914}; # EcoGene EG11789 gmm # FUNCTION GMM_ECOLI Hydrolyzes both GDP-mannose and GDP-glucose. Could participate in the regulation of cell wall biosynthesis by influencing the concentration of GDP-mannose or GDP-glucose in the cell. Might also be involved in the biosynthesis of the slime polysaccharide colanic acid. {ECO 0000269|PubMed 10913267, ECO 0000269|PubMed 7592609}. # GO_function GO:0000287 magnesium ion binding; IMP:EcoCyc. # GO_function GO:0008727 GDP-mannose mannosyl hydrolase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0030145 manganese ion binding; IMP:EcoCyc. # GO_function GO:0047917 GDP-glucosidase activity; IDA:EcoCyc. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IEA:UniProtKB-KW. # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.90.79.10 -; 1. # HAMAP MF_00941 GDPMH_gmm # InterPro IPR000086 NUDIX_hydrolase_dom # InterPro IPR015797 NUDIX_hydrolase_dom-like # InterPro IPR020084 NUDIX_hydrolase_CS # InterPro IPR028613 GDPMH_Gmm # InterPro IPR033715 GDPMH # KEGG_Brite ko01000 Enzymes # MASS SPECTROMETRY Mass=18472; Mass_error=67; Method=MALDI; Range=1-159; Evidence={ECO:0000269|PubMed 10913267}; # Organism GMM_ECOLI Escherichia coli (strain K12) # PATRIC 32119435 VBIEscCol129921_2128 # PDB 1RYA X-ray; 1.30 A; A/B=1-159 # PDB 2GT2 X-ray; 2.00 A; A/B/C/D=1-159 # PDB 2GT4 X-ray; 2.30 A; A/B/C=1-159 # PIR E55239 E55239 # PIRSF PIRSF037599 GDPMH # PROSITE PS00893 NUDIX_BOX # PROSITE PS51462 NUDIX # Pfam PF00293 NUDIX # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GDP-mannose mannosyl hydrolase {ECO:0000255|HAMAP-Rule MF_00941} # RefSeq NP_416555 NC_000913.3 # RefSeq WP_001393539 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAC77844.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the Nudix hydrolase family. {ECO:0000255|HAMAP-Rule MF_00941}. # SIMILARITY Contains 1 nudix hydrolase domain. {ECO:0000255|HAMAP- Rule MF_00941}. # SUBUNIT GMM_ECOLI Homodimer. {ECO 0000255|HAMAP-Rule MF_00941, ECO 0000269|PubMed 10913267, ECO 0000269|PubMed 15274914, ECO 0000269|PubMed 16981689}. # SUPFAM SSF55811 SSF55811 # eggNOG COG0494 LUCA # eggNOG ENOG4105FGF Bacteria BLAST swissprot:GMM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GMM_ECOLI BioCyc ECOL316407:JW5335-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5335-MONOMER BioCyc EcoCyc:GDPMANMANHYDRO-MONOMER http://biocyc.org/getid?id=EcoCyc:GDPMANMANHYDRO-MONOMER BioCyc MetaCyc:GDPMANMANHYDRO-MONOMER http://biocyc.org/getid?id=MetaCyc:GDPMANMANHYDRO-MONOMER COG COG0494 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0494 DOI 10.1016/j.str.2004.03.028 http://dx.doi.org/10.1016/j.str.2004.03.028 DOI 10.1021/bi000537p http://dx.doi.org/10.1021/bi000537p DOI 10.1021/bi020362e http://dx.doi.org/10.1021/bi020362e DOI 10.1021/bi050583v http://dx.doi.org/10.1021/bi050583v DOI 10.1021/bi061239g http://dx.doi.org/10.1021/bi061239g DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.270.41.24086 http://dx.doi.org/10.1074/jbc.270.41.24086 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.1.- {ECO:0000255|HAMAP-Rule:MF_00941} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.1.- {ECO:0000255|HAMAP-Rule:MF_00941} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U38473 http://www.ebi.ac.uk/ena/data/view/U38473 ENZYME 3.6.1.- {ECO:0000255|HAMAP-Rule:MF_00941} http://enzyme.expasy.org/EC/3.6.1.- {ECO:0000255|HAMAP-Rule:MF_00941} EchoBASE EB1737 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1737 EcoGene EG11789 http://www.ecogene.org/geneInfo.php?eg_id=EG11789 EnsemblBacteria AAC75112 http://www.ensemblgenomes.org/id/AAC75112 EnsemblBacteria AAC75112 http://www.ensemblgenomes.org/id/AAC75112 EnsemblBacteria BAA15907 http://www.ensemblgenomes.org/id/BAA15907 EnsemblBacteria BAA15907 http://www.ensemblgenomes.org/id/BAA15907 EnsemblBacteria BAA15907 http://www.ensemblgenomes.org/id/BAA15907 EnsemblBacteria b2051 http://www.ensemblgenomes.org/id/b2051 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0008727 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008727 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_function GO:0047917 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047917 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.90.79.10 http://www.cathdb.info/version/latest/superfamily/3.90.79.10 GeneID 946559 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946559 HAMAP MF_00941 http://hamap.expasy.org/unirule/MF_00941 HOGENOM HOG000280400 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000280400&db=HOGENOM6 InParanoid P32056 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32056 IntEnz 3.6.1.- {ECO:0000255|HAMAP-Rule:MF_00941} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.1.- {ECO:0000255|HAMAP-Rule:MF_00941} InterPro IPR000086 http://www.ebi.ac.uk/interpro/entry/IPR000086 InterPro IPR015797 http://www.ebi.ac.uk/interpro/entry/IPR015797 InterPro IPR020084 http://www.ebi.ac.uk/interpro/entry/IPR020084 InterPro IPR028613 http://www.ebi.ac.uk/interpro/entry/IPR028613 InterPro IPR033715 http://www.ebi.ac.uk/interpro/entry/IPR033715 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5335 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5335 KEGG_Gene eco:b2051 http://www.genome.jp/dbget-bin/www_bget?eco:b2051 KEGG_Orthology KO:K03207 http://www.genome.jp/dbget-bin/www_bget?KO:K03207 OMA HDNSRAY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HDNSRAY PDB 1RYA http://www.ebi.ac.uk/pdbe-srv/view/entry/1RYA PDB 2GT2 http://www.ebi.ac.uk/pdbe-srv/view/entry/2GT2 PDB 2GT4 http://www.ebi.ac.uk/pdbe-srv/view/entry/2GT4 PDBsum 1RYA http://www.ebi.ac.uk/pdbsum/1RYA PDBsum 2GT2 http://www.ebi.ac.uk/pdbsum/2GT2 PDBsum 2GT4 http://www.ebi.ac.uk/pdbsum/2GT4 PROSITE PS00893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00893 PROSITE PS51462 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51462 PSORT swissprot:GMM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GMM_ECOLI PSORT-B swissprot:GMM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GMM_ECOLI PSORT2 swissprot:GMM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GMM_ECOLI Pfam PF00293 http://pfam.xfam.org/family/PF00293 Phobius swissprot:GMM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GMM_ECOLI PhylomeDB P32056 http://phylomedb.org/?seqid=P32056 ProteinModelPortal P32056 http://www.proteinmodelportal.org/query/uniprot/P32056 PubMed 10913267 http://www.ncbi.nlm.nih.gov/pubmed/10913267 PubMed 12196023 http://www.ncbi.nlm.nih.gov/pubmed/12196023 PubMed 15274914 http://www.ncbi.nlm.nih.gov/pubmed/15274914 PubMed 15966723 http://www.ncbi.nlm.nih.gov/pubmed/15966723 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16981689 http://www.ncbi.nlm.nih.gov/pubmed/16981689 PubMed 7592609 http://www.ncbi.nlm.nih.gov/pubmed/7592609 PubMed 7815923 http://www.ncbi.nlm.nih.gov/pubmed/7815923 PubMed 8759852 http://www.ncbi.nlm.nih.gov/pubmed/8759852 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416555 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416555 RefSeq WP_001393539 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001393539 SMR P32056 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32056 STRING 511145.b2051 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2051&targetmode=cogs STRING COG0494 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0494&targetmode=cogs SUPFAM SSF55811 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55811 UniProtKB GMM_ECOLI http://www.uniprot.org/uniprot/GMM_ECOLI UniProtKB-AC P32056 http://www.uniprot.org/uniprot/P32056 charge swissprot:GMM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GMM_ECOLI eggNOG COG0494 http://eggnogapi.embl.de/nog_data/html/tree/COG0494 eggNOG ENOG4105FGF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FGF epestfind swissprot:GMM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GMM_ECOLI garnier swissprot:GMM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GMM_ECOLI helixturnhelix swissprot:GMM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GMM_ECOLI hmoment swissprot:GMM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GMM_ECOLI iep swissprot:GMM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GMM_ECOLI inforesidue swissprot:GMM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GMM_ECOLI octanol swissprot:GMM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GMM_ECOLI pepcoil swissprot:GMM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GMM_ECOLI pepdigest swissprot:GMM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GMM_ECOLI pepinfo swissprot:GMM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GMM_ECOLI pepnet swissprot:GMM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GMM_ECOLI pepstats swissprot:GMM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GMM_ECOLI pepwheel swissprot:GMM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GMM_ECOLI pepwindow swissprot:GMM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GMM_ECOLI sigcleave swissprot:GMM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GMM_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES TALB_ECOLI Kinetic parameters KM=38 uM for D,L-glyceraldehyde 3-phosphate (with C3 acceptor compounds at pH 8.5 and 30 degrees Celsius) {ECO 0000269|PubMed 7592346}; KM=90 uM for D-erythrose-4-phosphate (with C3 acceptor compounds at pH 8.5 and 30 degrees Celsius) {ECO 0000269|PubMed 7592346}; KM=31 mM for D-ribose-5-phosphate (with C3 acceptor compounds at pH 8.5 and 30 degrees Celsius) {ECO 0000269|PubMed 7592346}; KM=28 mM for D-glyceraldehyde (with C3 acceptor compounds at pH 8.5 and 30 degrees Celsius) {ECO 0000269|PubMed 7592346}; KM=285 uM for D-sedoheptulose-7-phosphate (with C3 donor compounds at pH 8.5 and 30 degrees Celsius) {ECO 0000269|PubMed 7592346}; KM=1200 uM for D-fructose-6-phosphate (with C3 donor compounds at pH 8.5 and 30 degrees Celsius) {ECO 0000269|PubMed 7592346}; pH dependence Optimum pH is between 8.5 and 9.5. {ECO 0000269|PubMed 7592346}; Temperature dependence Optimum temperature is between 15 and 40 degrees Celsius. At temperatures above 50 degrees Celsius, activity is lost rapidly, and at 55 degrees Celsius, the enzyme is totally inactivated. {ECO 0000269|PubMed 7592346}; # BRENDA 2.2.1 2026 # BioGrid 4261939 3 # CATALYTIC ACTIVITY Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate. {ECO:0000269|PubMed 7592346}. # CDD cd00957 Transaldolase_TalAB # ENZYME REGULATION Inhibited by Tris-HCl and phosphate buffer. Also competitively inhibited by sugars with L configuration at C2, such as D-arabinose-5-phosphate and L-glyceraldehyde. {ECO:0000269|PubMed 7592346}. # EcoGene EG11556 talB # FUNCTION TALB_ECOLI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. {ECO 0000269|PubMed 7592346}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0016744 transferase activity, transferring aldehyde or ketonic groups; IDA:EcoCyc. # GO_function TALB_ECOLI GO 0004801 sedoheptulose-7-phosphate D-glyceraldehyde-3-phosphate glyceronetransferase activity; IDA UniProtKB. # GO_process GO:0005975 carbohydrate metabolic process; IEA:InterPro. # GO_process GO:0009052 pentose-phosphate shunt, non-oxidative branch; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0008150 biological_process # Gene3D 3.20.20.70 -; 1. # HAMAP MF_00492 Transaldolase_1 # IntAct P0A870 6 # InterPro IPR001585 TAL/FSA # InterPro IPR004730 Transaldolase_1 # InterPro IPR013785 Aldolase_TIM # InterPro IPR018225 Transaldolase_AS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00030 Pentose phosphate pathway # Organism TALB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10683 PTHR10683 # PATHWAY Carbohydrate degradation; pentose phosphate pathway; D- glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D- ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage) step 2/3. # PATRIC 32115111 VBIEscCol129921_0007 # PDB 1I2N X-ray; 2.05 A; A/B=2-317 # PDB 1I2O X-ray; 2.05 A; A/B=2-317 # PDB 1I2P X-ray; 2.05 A; A/B=2-317 # PDB 1I2Q X-ray; 2.05 A; A/B=2-317 # PDB 1I2R X-ray; 2.10 A; A/B=2-317 # PDB 1ONR X-ray; 1.87 A; A/B=2-317 # PDB 1UCW X-ray; 2.20 A; A/B=1-317 # PDB 3KOF X-ray; 1.90 A; A/B=1-317 # PDB 4RZ5 X-ray; 1.80 A; A/B=1-317 # PDB 4RZ6 X-ray; 1.80 A; A/B=1-317 # PDB 4S2B X-ray; 1.46 A; A/B=1-317 # PDB 4S2C X-ray; 2.20 A; A/B=1-317 # PIR S40535 S40535 # PROSITE PS00958 TRANSALDOLASE_2 # PROSITE PS01054 TRANSALDOLASE_1 # Pfam PF00923 TAL_FSA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TALB_ECOLI Transaldolase B # RefSeq NP_414549 NC_000913.3 # RefSeq WP_000130185 NZ_LN832404.1 # SIMILARITY Belongs to the transaldolase family. Type 1 subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION TALB_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT TALB_ECOLI Homodimer. {ECO 0000269|PubMed 7592346, ECO 0000269|PubMed 8805555}. # TIGRFAMs TIGR00874 talAB # UniPathway UPA00115 UER00414 # WEB RESOURCE TALB_ECOLI Name=Wikipedia; Note=Transaldolase B entry; URL="https //en.wikipedia.org/wiki/Transaldolase_B"; # eggNOG COG0176 LUCA # eggNOG ENOG4105CW3 Bacteria BLAST swissprot:TALB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TALB_ECOLI BioCyc ECOL316407:JW0007-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0007-MONOMER BioCyc EcoCyc:TRANSALDOLB-MONOMER http://biocyc.org/getid?id=EcoCyc:TRANSALDOLB-MONOMER BioCyc MetaCyc:TRANSALDOLB-MONOMER http://biocyc.org/getid?id=MetaCyc:TRANSALDOLB-MONOMER COG COG0176 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0176 DIP DIP-31850N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31850N DOI 10.1002/cbic.200900720 http://dx.doi.org/10.1002/cbic.200900720 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1002/pro.5560060113 http://dx.doi.org/10.1002/pro.5560060113 DOI 10.1016/S0969-2126(96)00077-9 http://dx.doi.org/10.1016/S0969-2126(96)00077-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1432-1327.2001.02128.x http://dx.doi.org/10.1046/j.1432-1327.2001.02128.x DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.2.1.2 http://www.genome.jp/dbget-bin/www_bget?EC:2.2.1.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D13161 http://www.ebi.ac.uk/ena/data/view/D13161 EMBL S80045 http://www.ebi.ac.uk/ena/data/view/S80045 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.2.1.2 http://enzyme.expasy.org/EC/2.2.1.2 EchoBASE EB1517 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1517 EcoGene EG11556 http://www.ecogene.org/geneInfo.php?eg_id=EG11556 EnsemblBacteria AAC73119 http://www.ensemblgenomes.org/id/AAC73119 EnsemblBacteria AAC73119 http://www.ensemblgenomes.org/id/AAC73119 EnsemblBacteria BAB96586 http://www.ensemblgenomes.org/id/BAB96586 EnsemblBacteria BAB96586 http://www.ensemblgenomes.org/id/BAB96586 EnsemblBacteria BAB96586 http://www.ensemblgenomes.org/id/BAB96586 EnsemblBacteria b0008 http://www.ensemblgenomes.org/id/b0008 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0004801 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004801 GO_function GO:0016744 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016744 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GO_process GO:0009052 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009052 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 944748 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944748 HAMAP MF_00492 http://hamap.expasy.org/unirule/MF_00492 HOGENOM HOG000281234 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000281234&db=HOGENOM6 InParanoid P0A870 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A870 IntAct P0A870 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A870* IntEnz 2.2.1.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.2.1.2 InterPro IPR001585 http://www.ebi.ac.uk/interpro/entry/IPR001585 InterPro IPR004730 http://www.ebi.ac.uk/interpro/entry/IPR004730 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR018225 http://www.ebi.ac.uk/interpro/entry/IPR018225 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0007 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0007 KEGG_Gene eco:b0008 http://www.genome.jp/dbget-bin/www_bget?eco:b0008 KEGG_Orthology KO:K00616 http://www.genome.jp/dbget-bin/www_bget?KO:K00616 KEGG_Pathway ko00030 http://www.genome.jp/kegg-bin/show_pathway?ko00030 KEGG_Reaction rn:R01827 http://www.genome.jp/dbget-bin/www_bget?rn:R01827 OMA EYAGNED http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EYAGNED PANTHER PTHR10683 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10683 PDB 1I2N http://www.ebi.ac.uk/pdbe-srv/view/entry/1I2N PDB 1I2O http://www.ebi.ac.uk/pdbe-srv/view/entry/1I2O PDB 1I2P http://www.ebi.ac.uk/pdbe-srv/view/entry/1I2P PDB 1I2Q http://www.ebi.ac.uk/pdbe-srv/view/entry/1I2Q PDB 1I2R http://www.ebi.ac.uk/pdbe-srv/view/entry/1I2R PDB 1ONR http://www.ebi.ac.uk/pdbe-srv/view/entry/1ONR PDB 1UCW http://www.ebi.ac.uk/pdbe-srv/view/entry/1UCW PDB 3KOF http://www.ebi.ac.uk/pdbe-srv/view/entry/3KOF PDB 4RZ5 http://www.ebi.ac.uk/pdbe-srv/view/entry/4RZ5 PDB 4RZ6 http://www.ebi.ac.uk/pdbe-srv/view/entry/4RZ6 PDB 4S2B http://www.ebi.ac.uk/pdbe-srv/view/entry/4S2B PDB 4S2C http://www.ebi.ac.uk/pdbe-srv/view/entry/4S2C PDBsum 1I2N http://www.ebi.ac.uk/pdbsum/1I2N PDBsum 1I2O http://www.ebi.ac.uk/pdbsum/1I2O PDBsum 1I2P http://www.ebi.ac.uk/pdbsum/1I2P PDBsum 1I2Q http://www.ebi.ac.uk/pdbsum/1I2Q PDBsum 1I2R http://www.ebi.ac.uk/pdbsum/1I2R PDBsum 1ONR http://www.ebi.ac.uk/pdbsum/1ONR PDBsum 1UCW http://www.ebi.ac.uk/pdbsum/1UCW PDBsum 3KOF http://www.ebi.ac.uk/pdbsum/3KOF PDBsum 4RZ5 http://www.ebi.ac.uk/pdbsum/4RZ5 PDBsum 4RZ6 http://www.ebi.ac.uk/pdbsum/4RZ6 PDBsum 4S2B http://www.ebi.ac.uk/pdbsum/4S2B PDBsum 4S2C http://www.ebi.ac.uk/pdbsum/4S2C PROSITE PS00958 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00958 PROSITE PS01054 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01054 PSORT swissprot:TALB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TALB_ECOLI PSORT-B swissprot:TALB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TALB_ECOLI PSORT2 swissprot:TALB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TALB_ECOLI Pfam PF00923 http://pfam.xfam.org/family/PF00923 Phobius swissprot:TALB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TALB_ECOLI PhylomeDB P0A870 http://phylomedb.org/?seqid=P0A870 ProteinModelPortal P0A870 http://www.proteinmodelportal.org/query/uniprot/P0A870 PubMed 11298760 http://www.ncbi.nlm.nih.gov/pubmed/11298760 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20148428 http://www.ncbi.nlm.nih.gov/pubmed/20148428 PubMed 7592346 http://www.ncbi.nlm.nih.gov/pubmed/7592346 PubMed 8805555 http://www.ncbi.nlm.nih.gov/pubmed/8805555 PubMed 9007983 http://www.ncbi.nlm.nih.gov/pubmed/9007983 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_414549 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414549 RefSeq WP_000130185 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000130185 SMR P0A870 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A870 STRING 511145.b0008 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0008&targetmode=cogs STRING COG0176 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0176&targetmode=cogs SWISS-2DPAGE P0A870 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A870 TIGRFAMs TIGR00874 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00874 UniProtKB TALB_ECOLI http://www.uniprot.org/uniprot/TALB_ECOLI UniProtKB-AC P0A870 http://www.uniprot.org/uniprot/P0A870 charge swissprot:TALB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TALB_ECOLI eggNOG COG0176 http://eggnogapi.embl.de/nog_data/html/tree/COG0176 eggNOG ENOG4105CW3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CW3 epestfind swissprot:TALB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TALB_ECOLI garnier swissprot:TALB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TALB_ECOLI helixturnhelix swissprot:TALB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TALB_ECOLI hmoment swissprot:TALB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TALB_ECOLI iep swissprot:TALB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TALB_ECOLI inforesidue swissprot:TALB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TALB_ECOLI octanol swissprot:TALB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TALB_ECOLI pepcoil swissprot:TALB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TALB_ECOLI pepdigest swissprot:TALB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TALB_ECOLI pepinfo swissprot:TALB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TALB_ECOLI pepnet swissprot:TALB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TALB_ECOLI pepstats swissprot:TALB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TALB_ECOLI pepwheel swissprot:TALB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TALB_ECOLI pepwindow swissprot:TALB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TALB_ECOLI sigcleave swissprot:TALB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TALB_ECOLI ## Database ID URL or Descriptions # AltName Glutamate-5-semialdehyde dehydrogenase {ECO:0000255|HAMAP-Rule MF_00412} # AltName Glutamyl-gamma-semialdehyde dehydrogenase {ECO:0000255|HAMAP-Rule MF_00412} # BIOPHYSICOCHEMICAL PROPERTIES pH dependence: Optimum pH is 7.0. {ECO 0000269|PubMed:7035170}; # BioGrid 4259768 16 # CATALYTIC ACTIVITY PROA_ECOLI L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH. {ECO 0000255|HAMAP- Rule MF_00412, ECO 0000269|PubMed 7034716, ECO 0000269|PubMed 7035170}. # CDD cd07079 ALDH_F18-19_ProA-GPR # ENZYME REGULATION Inhibited by p-chloromercuribenzoate, copper and nickel ions. {ECO:0000269|PubMed 7035170}. # EcoGene EG10767 proA # FUNCTION PROA_ECOLI Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate. {ECO 0000255|HAMAP-Rule MF_00412, ECO 0000269|PubMed 7034716, ECO 0000269|PubMed 7035170}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004350 glutamate-5-semialdehyde dehydrogenase activity; IDA:EcoCyc. # GO_function GO:0050661 NADP binding; IDA:EcoCyc. # GO_process GO:0055129 L-proline biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.309.10 -; 1. # Gene3D 3.40.605.10 -; 2. # HAMAP MF_00412 ProA # IntAct P07004 17 # InterPro IPR000965 GPR_dom # InterPro IPR012134 Glu-5-SA_DH # InterPro IPR015590 Aldehyde_DH_dom # InterPro IPR016161 Ald_DH/histidinol_DH # InterPro IPR016162 Ald_DH_N # InterPro IPR016163 Ald_DH_C # InterPro IPR020593 G-glutamylP_reductase_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00330 Arginine and proline metabolism # Organism PROA_ECOLI Escherichia coli (strain K12) # PATHWAY PROA_ECOLI Amino-acid biosynthesis; L-proline biosynthesis; L- glutamate 5-semialdehyde from L-glutamate step 2/2. {ECO 0000255|HAMAP-Rule MF_00412, ECO 0000269|PubMed 7035170}. # PATRIC 32115601 VBIEscCol129921_0245 # PIR D64749 RDECER # PIRSF PIRSF000151 GPR # PROSITE PS01223 PROA # Pfam PF00171 Aldedh # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Gamma-glutamyl phosphate reductase {ECO:0000255|HAMAP-Rule MF_00412} # RefSeq NP_414778 NC_000913.3 # RefSeq WP_000893278 NZ_LN832404.1 # SIMILARITY Belongs to the gamma-glutamyl phosphate reductase family. {ECO:0000255|HAMAP-Rule MF_00412}. # SUBCELLULAR LOCATION PROA_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00412}. # SUBUNIT PROA_ECOLI Homodimer (Probable). May form a complex with glutamate 5-kinase (proB). {ECO 0000269|PubMed 6319365, ECO 0000269|PubMed 7035170, ECO 0000305}. # SUPFAM SSF53720 SSF53720 # TIGRFAMs TIGR00407 proA # UniPathway UPA00098 UER00360 # eggNOG COG0014 LUCA # eggNOG ENOG4105C2S Bacteria BLAST swissprot:PROA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PROA_ECOLI BioCyc ECOL316407:JW0233-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0233-MONOMER BioCyc EcoCyc:GLUTSEMIALDEHYDROG-MONOMER http://biocyc.org/getid?id=EcoCyc:GLUTSEMIALDEHYDROG-MONOMER BioCyc MetaCyc:GLUTSEMIALDEHYDROG-MONOMER http://biocyc.org/getid?id=MetaCyc:GLUTSEMIALDEHYDROG-MONOMER COG COG0014 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0014 DIP DIP-10568N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10568N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj1970269 http://dx.doi.org/10.1042/bj1970269 DOI 10.1093/nar/12.15.6337 http://dx.doi.org/10.1093/nar/12.15.6337 DOI 10.1111/j.1365-2958.1992.tb01788.x http://dx.doi.org/10.1111/j.1365-2958.1992.tb01788.x DOI 10.1111/j.1432-1033.1982.tb05823.x http://dx.doi.org/10.1111/j.1432-1033.1982.tb05823.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.2.1.41 {ECO:0000255|HAMAP-Rule:MF_00412} http://www.genome.jp/dbget-bin/www_bget?EC:1.2.1.41 {ECO:0000255|HAMAP-Rule:MF_00412} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EMBL X00786 http://www.ebi.ac.uk/ena/data/view/X00786 EMBL Z12832 http://www.ebi.ac.uk/ena/data/view/Z12832 ENZYME 1.2.1.41 {ECO:0000255|HAMAP-Rule:MF_00412} http://enzyme.expasy.org/EC/1.2.1.41 {ECO:0000255|HAMAP-Rule:MF_00412} EchoBASE EB0760 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0760 EcoGene EG10767 http://www.ecogene.org/geneInfo.php?eg_id=EG10767 EnsemblBacteria AAC73347 http://www.ensemblgenomes.org/id/AAC73347 EnsemblBacteria AAC73347 http://www.ensemblgenomes.org/id/AAC73347 EnsemblBacteria BAA77912 http://www.ensemblgenomes.org/id/BAA77912 EnsemblBacteria BAA77912 http://www.ensemblgenomes.org/id/BAA77912 EnsemblBacteria BAA77912 http://www.ensemblgenomes.org/id/BAA77912 EnsemblBacteria b0243 http://www.ensemblgenomes.org/id/b0243 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004350 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004350 GO_function GO:0050661 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050661 GO_process GO:0055129 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055129 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.309.10 http://www.cathdb.info/version/latest/superfamily/3.40.309.10 Gene3D 3.40.605.10 http://www.cathdb.info/version/latest/superfamily/3.40.605.10 GeneID 946680 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946680 HAMAP MF_00412 http://hamap.expasy.org/unirule/MF_00412 HOGENOM HOG000246356 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000246356&db=HOGENOM6 InParanoid P07004 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P07004 IntAct P07004 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P07004* IntEnz 1.2.1.41 {ECO:0000255|HAMAP-Rule:MF_00412} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.2.1.41 {ECO:0000255|HAMAP-Rule:MF_00412} InterPro IPR000965 http://www.ebi.ac.uk/interpro/entry/IPR000965 InterPro IPR012134 http://www.ebi.ac.uk/interpro/entry/IPR012134 InterPro IPR015590 http://www.ebi.ac.uk/interpro/entry/IPR015590 InterPro IPR016161 http://www.ebi.ac.uk/interpro/entry/IPR016161 InterPro IPR016162 http://www.ebi.ac.uk/interpro/entry/IPR016162 InterPro IPR016163 http://www.ebi.ac.uk/interpro/entry/IPR016163 InterPro IPR020593 http://www.ebi.ac.uk/interpro/entry/IPR020593 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0233 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0233 KEGG_Gene eco:b0243 http://www.genome.jp/dbget-bin/www_bget?eco:b0243 KEGG_Orthology KO:K00147 http://www.genome.jp/dbget-bin/www_bget?KO:K00147 KEGG_Pathway ko00330 http://www.genome.jp/kegg-bin/show_pathway?ko00330 KEGG_Reaction rn:R03313 http://www.genome.jp/dbget-bin/www_bget?rn:R03313 MINT MINT-1261639 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1261639 OMA CNAIETL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CNAIETL PROSITE PS01223 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01223 PSORT swissprot:PROA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PROA_ECOLI PSORT-B swissprot:PROA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PROA_ECOLI PSORT2 swissprot:PROA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PROA_ECOLI Pfam PF00171 http://pfam.xfam.org/family/PF00171 Phobius swissprot:PROA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PROA_ECOLI PhylomeDB P07004 http://phylomedb.org/?seqid=P07004 ProteinModelPortal P07004 http://www.proteinmodelportal.org/query/uniprot/P07004 PubMed 1282191 http://www.ncbi.nlm.nih.gov/pubmed/1282191 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6089111 http://www.ncbi.nlm.nih.gov/pubmed/6089111 PubMed 6319365 http://www.ncbi.nlm.nih.gov/pubmed/6319365 PubMed 7034716 http://www.ncbi.nlm.nih.gov/pubmed/7034716 PubMed 7035170 http://www.ncbi.nlm.nih.gov/pubmed/7035170 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414778 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414778 RefSeq WP_000893278 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000893278 SMR P07004 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P07004 STRING 511145.b0243 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0243&targetmode=cogs STRING COG0014 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0014&targetmode=cogs SUPFAM SSF53720 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53720 SWISS-2DPAGE P07004 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P07004 TIGRFAMs TIGR00407 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00407 UniProtKB PROA_ECOLI http://www.uniprot.org/uniprot/PROA_ECOLI UniProtKB-AC P07004 http://www.uniprot.org/uniprot/P07004 charge swissprot:PROA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PROA_ECOLI eggNOG COG0014 http://eggnogapi.embl.de/nog_data/html/tree/COG0014 eggNOG ENOG4105C2S http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C2S epestfind swissprot:PROA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PROA_ECOLI garnier swissprot:PROA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PROA_ECOLI helixturnhelix swissprot:PROA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PROA_ECOLI hmoment swissprot:PROA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PROA_ECOLI iep swissprot:PROA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PROA_ECOLI inforesidue swissprot:PROA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PROA_ECOLI octanol swissprot:PROA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PROA_ECOLI pepcoil swissprot:PROA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PROA_ECOLI pepdigest swissprot:PROA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PROA_ECOLI pepinfo swissprot:PROA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PROA_ECOLI pepnet swissprot:PROA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PROA_ECOLI pepstats swissprot:PROA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PROA_ECOLI pepwheel swissprot:PROA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PROA_ECOLI pepwindow swissprot:PROA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PROA_ECOLI sigcleave swissprot:PROA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PROA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260074 9 # EcoGene EG14269 flgE # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0009424 bacterial-type flagellum hook; IMP:EcoliWiki. # GO_component GO:0009425 bacterial-type flagellum basal body; IEA:UniProtKB-SubCell. # GO_process GO:0071978 bacterial-type flagellum-dependent swarming motility; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_process GO:0048870 cell motility # IntAct P75937 3 # InterPro IPR001444 Flag_bb_rod_N # InterPro IPR010930 Flg_bb/hook_C_dom # InterPro IPR011491 Falgellar_hook_FlgE # InterPro IPR019776 Flagellar_basal_body_rod_CS # InterPro IPR020013 Flagellar_FlgE/F/G # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Pathway ko02040 Flagellar assembly # Organism FLGE_ECOLI Escherichia coli (strain K12) # PATRIC 32117393 VBIEscCol129921_1119 # PIR A64851 A64851 # PROSITE PS00588 FLAGELLA_BB_ROD # Pfam PF00460 Flg_bb_rod # Pfam PF06429 Flg_bbr_C # Pfam PF07559 FlaE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FLGE_ECOLI Flagellar hook protein FlgE # RefSeq NP_415594 NC_000913.3 # RefSeq WP_000885873 NZ_LN832404.1 # SIMILARITY Belongs to the flagella basal body rod proteins family. {ECO 0000305}. # SUBCELLULAR LOCATION FLGE_ECOLI Bacterial flagellum basal body {ECO 0000250}. # TIGRFAMs TIGR03506 FlgEFG_subfam # eggNOG COG1749 LUCA # eggNOG ENOG4105BZE Bacteria BLAST swissprot:FLGE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLGE_ECOLI BioCyc ECOL316407:JW1063-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1063-MONOMER BioCyc EcoCyc:G361-MONOMER http://biocyc.org/getid?id=EcoCyc:G361-MONOMER COG COG1749 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1749 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4017 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4017 EcoGene EG14269 http://www.ecogene.org/geneInfo.php?eg_id=EG14269 EnsemblBacteria AAC74160 http://www.ensemblgenomes.org/id/AAC74160 EnsemblBacteria AAC74160 http://www.ensemblgenomes.org/id/AAC74160 EnsemblBacteria BAA35885 http://www.ensemblgenomes.org/id/BAA35885 EnsemblBacteria BAA35885 http://www.ensemblgenomes.org/id/BAA35885 EnsemblBacteria BAA35885 http://www.ensemblgenomes.org/id/BAA35885 EnsemblBacteria b1076 http://www.ensemblgenomes.org/id/b1076 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0009424 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009424 GO_component GO:0009425 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009425 GO_process GO:0071978 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071978 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 GeneID 945636 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945636 HOGENOM HOG000254240 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000254240&db=HOGENOM6 InParanoid P75937 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75937 IntAct P75937 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75937* InterPro IPR001444 http://www.ebi.ac.uk/interpro/entry/IPR001444 InterPro IPR010930 http://www.ebi.ac.uk/interpro/entry/IPR010930 InterPro IPR011491 http://www.ebi.ac.uk/interpro/entry/IPR011491 InterPro IPR019776 http://www.ebi.ac.uk/interpro/entry/IPR019776 InterPro IPR020013 http://www.ebi.ac.uk/interpro/entry/IPR020013 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW1063 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1063 KEGG_Gene eco:b1076 http://www.genome.jp/dbget-bin/www_bget?eco:b1076 KEGG_Orthology KO:K02390 http://www.genome.jp/dbget-bin/www_bget?KO:K02390 KEGG_Pathway ko02040 http://www.genome.jp/kegg-bin/show_pathway?ko02040 OMA NLVNTQG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NLVNTQG PROSITE PS00588 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00588 PSORT swissprot:FLGE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLGE_ECOLI PSORT-B swissprot:FLGE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLGE_ECOLI PSORT2 swissprot:FLGE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLGE_ECOLI Pfam PF00460 http://pfam.xfam.org/family/PF00460 Pfam PF06429 http://pfam.xfam.org/family/PF06429 Pfam PF07559 http://pfam.xfam.org/family/PF07559 Phobius swissprot:FLGE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLGE_ECOLI PhylomeDB P75937 http://phylomedb.org/?seqid=P75937 ProteinModelPortal P75937 http://www.proteinmodelportal.org/query/uniprot/P75937 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415594 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415594 RefSeq WP_000885873 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000885873 SMR P75937 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75937 STRING 511145.b1076 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1076&targetmode=cogs STRING COG1749 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1749&targetmode=cogs TIGRFAMs TIGR03506 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03506 UniProtKB FLGE_ECOLI http://www.uniprot.org/uniprot/FLGE_ECOLI UniProtKB-AC P75937 http://www.uniprot.org/uniprot/P75937 charge swissprot:FLGE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLGE_ECOLI eggNOG COG1749 http://eggnogapi.embl.de/nog_data/html/tree/COG1749 eggNOG ENOG4105BZE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZE epestfind swissprot:FLGE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLGE_ECOLI garnier swissprot:FLGE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLGE_ECOLI helixturnhelix swissprot:FLGE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLGE_ECOLI hmoment swissprot:FLGE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLGE_ECOLI iep swissprot:FLGE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLGE_ECOLI inforesidue swissprot:FLGE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLGE_ECOLI octanol swissprot:FLGE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLGE_ECOLI pepcoil swissprot:FLGE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLGE_ECOLI pepdigest swissprot:FLGE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLGE_ECOLI pepinfo swissprot:FLGE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLGE_ECOLI pepnet swissprot:FLGE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLGE_ECOLI pepstats swissprot:FLGE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLGE_ECOLI pepwheel swissprot:FLGE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLGE_ECOLI pepwindow swissprot:FLGE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLGE_ECOLI sigcleave swissprot:FLGE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLGE_ECOLI ## Database ID URL or Descriptions # AltName RLUF_ECOLI Ribosomal large subunit pseudouridine synthase F # AltName RLUF_ECOLI rRNA pseudouridylate synthase F # AltName RLUF_ECOLI rRNA-uridine isomerase F # BRENDA 5.4.99.21 2026 # BioGrid 4261777 6 # CATALYTIC ACTIVITY RLUF_ECOLI 23S rRNA uridine(2604) = 23S rRNA pseudouridine(2604). {ECO 0000269|PubMed 11720289, ECO 0000269|PubMed 19298824}. # EcoGene EG11921 rluF # FUNCTION RLUF_ECOLI Catalyzes the synthesis of pseudouridine from uracil- 2604 in 23S ribosomal RNA. Can, to a small extent, also react with uracil-2605. {ECO 0000269|PubMed 11720289}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0003723 RNA binding; IEA:UniProtKB-KW. # GO_function GO:0009982 pseudouridine synthase activity; IMP:EcoCyc. # GO_process GO:0000455 enzyme-directed rRNA pseudouridine synthesis; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.10.290.10 -; 1. # IntAct P32684 9 # InterPro IPR000748 PsdUridine_synth_RsuA/RluB/E/F # InterPro IPR002942 S4_RNA-bd # InterPro IPR006145 PsdUridine_synth_RsuA/RluD # InterPro IPR018496 PsdUridine_synth_RsuA/RluB_CS # InterPro IPR020103 PsdUridine_synth_cat_dom # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # Organism RLUF_ECOLI Escherichia coli (strain K12) # PATRIC 32123573 VBIEscCol129921_4135 # PDB 2GML X-ray; 2.60 A; A/B=66-290 # PDB 3DH3 X-ray; 3.00 A; A/B/C/D=1-290 # PIR E65209 E65209 # PROSITE PS01149 PSI_RSU # PROSITE PS50889 S4 # Pfam PF00849 PseudoU_synth_2 # Pfam PF01479 S4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 23S rRNA pseudouridine(2604) synthase {ECO:0000305|PubMed 11720289} # RefSeq NP_418446 NC_000913.3 # RefSeq WP_000936377 NZ_LN832404.1 # SIMILARITY Belongs to the pseudouridine synthase RsuA family. {ECO 0000305}. # SIMILARITY Contains 1 S4 RNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00182}. # SMART SM00363 S4 # SUBUNIT RLUF_ECOLI Monomer. {ECO 0000269|PubMed 16712869, ECO 0000269|PubMed 19298824}. # SUPFAM SSF55120 SSF55120 # TIGRFAMs TIGR00093 TIGR00093 # eggNOG COG1187 LUCA # eggNOG ENOG4105FE9 Bacteria BLAST swissprot:RLUF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RLUF_ECOLI BioCyc ECOL316407:JW3982-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3982-MONOMER BioCyc EcoCyc:EG11921-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11921-MONOMER BioCyc MetaCyc:EG11921-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11921-MONOMER COG COG1187 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1187 DOI 10.1016/j.jmb.2006.04.019 http://dx.doi.org/10.1016/j.jmb.2006.04.019 DOI 10.1016/j.jmb.2009.03.029 http://dx.doi.org/10.1016/j.jmb.2009.03.029 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.4.99.21 {ECO:0000269|PubMed:11720289, ECO:0000269|PubMed:19298824} http://www.genome.jp/dbget-bin/www_bget?EC:5.4.99.21 {ECO:0000269|PubMed:11720289, ECO:0000269|PubMed:19298824} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 5.4.99.21 {ECO:0000269|PubMed:11720289, ECO:0000269|PubMed:19298824} http://enzyme.expasy.org/EC/5.4.99.21 {ECO:0000269|PubMed:11720289, ECO:0000269|PubMed:19298824} EchoBASE EB1865 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1865 EcoGene EG11921 http://www.ecogene.org/geneInfo.php?eg_id=EG11921 EnsemblBacteria AAC76992 http://www.ensemblgenomes.org/id/AAC76992 EnsemblBacteria AAC76992 http://www.ensemblgenomes.org/id/AAC76992 EnsemblBacteria BAE78024 http://www.ensemblgenomes.org/id/BAE78024 EnsemblBacteria BAE78024 http://www.ensemblgenomes.org/id/BAE78024 EnsemblBacteria BAE78024 http://www.ensemblgenomes.org/id/BAE78024 EnsemblBacteria b4022 http://www.ensemblgenomes.org/id/b4022 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0009982 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009982 GO_process GO:0000455 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000455 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.10.290.10 http://www.cathdb.info/version/latest/superfamily/3.10.290.10 GeneID 948519 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948519 HOGENOM HOG000044954 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000044954&db=HOGENOM6 InParanoid P32684 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32684 IntAct P32684 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32684* IntEnz 5.4.99.21 {ECO:0000269|PubMed:11720289, ECO:0000269|PubMed:19298824} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.4.99.21 {ECO:0000269|PubMed:11720289, ECO:0000269|PubMed:19298824} InterPro IPR000748 http://www.ebi.ac.uk/interpro/entry/IPR000748 InterPro IPR002942 http://www.ebi.ac.uk/interpro/entry/IPR002942 InterPro IPR006145 http://www.ebi.ac.uk/interpro/entry/IPR006145 InterPro IPR018496 http://www.ebi.ac.uk/interpro/entry/IPR018496 InterPro IPR020103 http://www.ebi.ac.uk/interpro/entry/IPR020103 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW3982 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3982 KEGG_Gene eco:b4022 http://www.genome.jp/dbget-bin/www_bget?eco:b4022 KEGG_Orthology KO:K06182 http://www.genome.jp/dbget-bin/www_bget?KO:K06182 OMA CEYLGYE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CEYLGYE PDB 2GML http://www.ebi.ac.uk/pdbe-srv/view/entry/2GML PDB 3DH3 http://www.ebi.ac.uk/pdbe-srv/view/entry/3DH3 PDBsum 2GML http://www.ebi.ac.uk/pdbsum/2GML PDBsum 3DH3 http://www.ebi.ac.uk/pdbsum/3DH3 PROSITE PS01149 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01149 PROSITE PS50889 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50889 PSORT swissprot:RLUF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RLUF_ECOLI PSORT-B swissprot:RLUF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RLUF_ECOLI PSORT2 swissprot:RLUF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RLUF_ECOLI Pfam PF00849 http://pfam.xfam.org/family/PF00849 Pfam PF01479 http://pfam.xfam.org/family/PF01479 Phobius swissprot:RLUF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RLUF_ECOLI PhylomeDB P32684 http://phylomedb.org/?seqid=P32684 ProteinModelPortal P32684 http://www.proteinmodelportal.org/query/uniprot/P32684 PubMed 11720289 http://www.ncbi.nlm.nih.gov/pubmed/11720289 PubMed 16712869 http://www.ncbi.nlm.nih.gov/pubmed/16712869 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19298824 http://www.ncbi.nlm.nih.gov/pubmed/19298824 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418446 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418446 RefSeq WP_000936377 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000936377 SMART SM00363 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00363 SMR P32684 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32684 STRING 511145.b4022 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4022&targetmode=cogs STRING COG1187 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1187&targetmode=cogs SUPFAM SSF55120 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55120 TIGRFAMs TIGR00093 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00093 UniProtKB RLUF_ECOLI http://www.uniprot.org/uniprot/RLUF_ECOLI UniProtKB-AC P32684 http://www.uniprot.org/uniprot/P32684 charge swissprot:RLUF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RLUF_ECOLI eggNOG COG1187 http://eggnogapi.embl.de/nog_data/html/tree/COG1187 eggNOG ENOG4105FE9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FE9 epestfind swissprot:RLUF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RLUF_ECOLI garnier swissprot:RLUF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RLUF_ECOLI helixturnhelix swissprot:RLUF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RLUF_ECOLI hmoment swissprot:RLUF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RLUF_ECOLI iep swissprot:RLUF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RLUF_ECOLI inforesidue swissprot:RLUF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RLUF_ECOLI octanol swissprot:RLUF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RLUF_ECOLI pepcoil swissprot:RLUF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RLUF_ECOLI pepdigest swissprot:RLUF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RLUF_ECOLI pepinfo swissprot:RLUF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RLUF_ECOLI pepnet swissprot:RLUF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RLUF_ECOLI pepstats swissprot:RLUF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RLUF_ECOLI pepwheel swissprot:RLUF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RLUF_ECOLI pepwindow swissprot:RLUF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RLUF_ECOLI sigcleave swissprot:RLUF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RLUF_ECOLI ## Database ID URL or Descriptions # BioGrid 4261800 11 # EcoGene EG12105 yeiE # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; EXP:EcoCyc. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; EXP:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR005119 LysR_subst-bd # InterPro IPR011991 WHTH_DNA-bd_dom # Organism YEIE_ECOLI Escherichia coli (strain K12) # PATRIC 32119663 VBIEscCol129921_2242 # PIR D64984 D64984 # PRINTS PR00039 HTHLYSR # PROSITE PS50931 HTH_LYSR # Pfam PF00126 HTH_1 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEIE_ECOLI Uncharacterized HTH-type transcriptional regulator YeiE # RefSeq NP_416662 NC_000913.3 # RefSeq WP_000548294 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lysR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00253}. # SUPFAM SSF46785 SSF46785 # eggNOG COG0583 LUCA # eggNOG ENOG4105DUM Bacteria BLAST swissprot:YEIE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEIE_ECOLI BioCyc ECOL316407:JW2144-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2144-MONOMER BioCyc EcoCyc:EG12105-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12105-MONOMER DIP DIP-11918N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11918N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M89774 http://www.ebi.ac.uk/ena/data/view/M89774 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2029 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2029 EcoGene EG12105 http://www.ecogene.org/geneInfo.php?eg_id=EG12105 EnsemblBacteria AAC75218 http://www.ensemblgenomes.org/id/AAC75218 EnsemblBacteria AAC75218 http://www.ensemblgenomes.org/id/AAC75218 EnsemblBacteria BAE76634 http://www.ensemblgenomes.org/id/BAE76634 EnsemblBacteria BAE76634 http://www.ensemblgenomes.org/id/BAE76634 EnsemblBacteria BAE76634 http://www.ensemblgenomes.org/id/BAE76634 EnsemblBacteria b2157 http://www.ensemblgenomes.org/id/b2157 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 946657 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946657 HOGENOM HOG000233518 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000233518&db=HOGENOM6 InParanoid P0ACR4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACR4 InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW2144 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2144 KEGG_Gene eco:b2157 http://www.genome.jp/dbget-bin/www_bget?eco:b2157 OMA RRINLNQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RRINLNQ PRINTS PR00039 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00039 PROSITE PS50931 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50931 PSORT swissprot:YEIE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEIE_ECOLI PSORT-B swissprot:YEIE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEIE_ECOLI PSORT2 swissprot:YEIE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEIE_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:YEIE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEIE_ECOLI PhylomeDB P0ACR4 http://phylomedb.org/?seqid=P0ACR4 ProteinModelPortal P0ACR4 http://www.proteinmodelportal.org/query/uniprot/P0ACR4 PubMed 1315732 http://www.ncbi.nlm.nih.gov/pubmed/1315732 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416662 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416662 RefSeq WP_000548294 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000548294 SMR P0ACR4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACR4 STRING 511145.b2157 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2157&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB YEIE_ECOLI http://www.uniprot.org/uniprot/YEIE_ECOLI UniProtKB-AC P0ACR4 http://www.uniprot.org/uniprot/P0ACR4 charge swissprot:YEIE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEIE_ECOLI eggNOG COG0583 http://eggnogapi.embl.de/nog_data/html/tree/COG0583 eggNOG ENOG4105DUM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DUM epestfind swissprot:YEIE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEIE_ECOLI garnier swissprot:YEIE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEIE_ECOLI helixturnhelix swissprot:YEIE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEIE_ECOLI hmoment swissprot:YEIE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEIE_ECOLI iep swissprot:YEIE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEIE_ECOLI inforesidue swissprot:YEIE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEIE_ECOLI octanol swissprot:YEIE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEIE_ECOLI pepcoil swissprot:YEIE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEIE_ECOLI pepdigest swissprot:YEIE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEIE_ECOLI pepinfo swissprot:YEIE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEIE_ECOLI pepnet swissprot:YEIE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEIE_ECOLI pepstats swissprot:YEIE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEIE_ECOLI pepwheel swissprot:YEIE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEIE_ECOLI pepwindow swissprot:YEIE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEIE_ECOLI sigcleave swissprot:YEIE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEIE_ECOLI ## Database ID URL or Descriptions # BioGrid 4259338 130 # CATALYTIC ACTIVITY RUVA_ECOLI ATP + H(2)O = ADP + phosphate. {ECO 0000255|HAMAP-Rule MF_00031, ECO 0000269|PubMed 8433990}. # CDD cd14332 UBA_RuvA_C # EcoGene EG10923 ruvA # FUNCTION RUVA_ECOLI The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. Binds both single- and double-stranded DNA (dsDNA). Binds preferentially to supercoiled rather than to relaxed dsDNA. {ECO 0000255|HAMAP-Rule MF_00031, ECO 0000269|PubMed 8433990}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_component GO:0009379 Holliday junction helicase complex; IDA:EcoCyc. # GO_component GO:0048476 Holliday junction resolvase complex; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0009378 four-way junction helicase activity; IDA:EcoCyc. # GO_process GO:0000725 recombinational repair; IMP:EcoCyc. # GO_process GO:0009432 SOS response; IEP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004386 helicase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # HAMAP MF_00031 DNA_helic_RuvA # INDUCTION RUVA_ECOLI Expression of the ruv region is induced by damage to DNA and is regulated by LexA as part of the SOS response. RuvA and RuvB are also involved in mutagenesis induced by UV and X irradiation and by some chemicals (PubMed 3279394). Induced by hydroxyurea (PubMed 20005847). {ECO 0000269|PubMed 20005847, ECO 0000269|PubMed 3279394}. # IntAct P0A809 7 # InterPro IPR000085 RuvA # InterPro IPR003583 Hlx-hairpin-Hlx_DNA-bd_motif # InterPro IPR010994 RuvA_2-like # InterPro IPR011114 RuvA_C # InterPro IPR012340 NA-bd_OB-fold # InterPro IPR013849 DNA_helicase_Holl-junc_RuvA_I # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko03440 Homologous recombination # Organism RUVA_ECOLI Escherichia coli (strain K12) # PATRIC 32119045 VBIEscCol129921_1940 # PDB 1BDX X-ray; 6.00 A; A/B/C/D=1-203 # PDB 1C7Y X-ray; 3.10 A; A=1-203 # PDB 1CUK X-ray; 1.90 A; A=1-203 # PDB 1D8L X-ray; 2.50 A; A/B=1-149 # PDB 1HJP X-ray; 2.50 A; A=1-203 # PIR E64948 BVECRV # Pfam PF01330 RuvA_N # Pfam PF07499 RuvA_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Holliday junction ATP-dependent DNA helicase RuvA {ECO:0000255|HAMAP-Rule MF_00031} # RefSeq NP_416375 NC_000913.3 # RefSeq WP_000580323 NZ_LN832404.1 # SIMILARITY Belongs to the RuvA family. {ECO:0000255|HAMAP- Rule MF_00031}. # SMART SM00278 HhH1; 2 # SUBCELLULAR LOCATION RUVA_ECOLI Cytoplasm {ECO 0000269|PubMed 21219465}. Note=In 15% of cell localizes to discrete nucleoid foci (probable DNA damage sites) upon treatment with mitomycin C (MMC) for 2 hours. # SUBUNIT RUVA_ECOLI Homotetramer; forms a complex with RuvB. {ECO 0000269|PubMed 8832889, ECO 0000269|PubMed 9493263}. # SUPFAM SSF46929 SSF46929 # SUPFAM SSF47781 SSF47781 # SUPFAM SSF50249 SSF50249 # TIGRFAMs TIGR00084 ruvA # eggNOG COG0632 LUCA # eggNOG ENOG4105KA4 Bacteria BLAST swissprot:RUVA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RUVA_ECOLI BioCyc ECOL316407:JW1850-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1850-MONOMER BioCyc EcoCyc:EG10923-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10923-MONOMER BioCyc MetaCyc:EG10923-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10923-MONOMER COG COG0632 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0632 DIP DIP-48064N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48064N DOI 10.1006/jmbi.2000.3675 http://dx.doi.org/10.1006/jmbi.2000.3675 DOI 10.1016/S0969-2126(98)00003-3 http://dx.doi.org/10.1016/S0969-2126(98)00003-3 DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb0698-441 http://dx.doi.org/10.1038/nsb0698-441 DOI 10.1073/pnas.90.4.1315 http://dx.doi.org/10.1073/pnas.90.4.1315 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/nar/16.4.1541 http://dx.doi.org/10.1093/nar/16.4.1541 DOI 10.1111/j.1365-2958.2010.07465.x http://dx.doi.org/10.1111/j.1365-2958.2010.07465.x DOI 10.1126/science.274.5286.415 http://dx.doi.org/10.1126/science.274.5286.415 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1146/annurev.genet.31.1.213 http://dx.doi.org/10.1146/annurev.genet.31.1.213 EC_number EC:3.6.4.12 {ECO:0000255|HAMAP-Rule:MF_00031} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.4.12 {ECO:0000255|HAMAP-Rule:MF_00031} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D10165 http://www.ebi.ac.uk/ena/data/view/D10165 EMBL M21298 http://www.ebi.ac.uk/ena/data/view/M21298 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X07091 http://www.ebi.ac.uk/ena/data/view/X07091 ENZYME 3.6.4.12 {ECO:0000255|HAMAP-Rule:MF_00031} http://enzyme.expasy.org/EC/3.6.4.12 {ECO:0000255|HAMAP-Rule:MF_00031} EchoBASE EB0916 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0916 EcoGene EG10923 http://www.ecogene.org/geneInfo.php?eg_id=EG10923 EnsemblBacteria AAC74931 http://www.ensemblgenomes.org/id/AAC74931 EnsemblBacteria AAC74931 http://www.ensemblgenomes.org/id/AAC74931 EnsemblBacteria BAA15672 http://www.ensemblgenomes.org/id/BAA15672 EnsemblBacteria BAA15672 http://www.ensemblgenomes.org/id/BAA15672 EnsemblBacteria BAA15672 http://www.ensemblgenomes.org/id/BAA15672 EnsemblBacteria b1861 http://www.ensemblgenomes.org/id/b1861 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0009379 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009379 GO_component GO:0048476 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048476 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0009378 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009378 GO_process GO:0000725 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000725 GO_process GO:0009432 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009432 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004386 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 946369 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946369 HAMAP MF_00031 http://hamap.expasy.org/unirule/MF_00031 HOGENOM HOG000057116 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000057116&db=HOGENOM6 InParanoid P0A809 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A809 IntAct P0A809 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A809* IntEnz 3.6.4.12 {ECO:0000255|HAMAP-Rule:MF_00031} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.4.12 {ECO:0000255|HAMAP-Rule:MF_00031} InterPro IPR000085 http://www.ebi.ac.uk/interpro/entry/IPR000085 InterPro IPR003583 http://www.ebi.ac.uk/interpro/entry/IPR003583 InterPro IPR010994 http://www.ebi.ac.uk/interpro/entry/IPR010994 InterPro IPR011114 http://www.ebi.ac.uk/interpro/entry/IPR011114 InterPro IPR012340 http://www.ebi.ac.uk/interpro/entry/IPR012340 InterPro IPR013849 http://www.ebi.ac.uk/interpro/entry/IPR013849 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW1850 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1850 KEGG_Gene eco:b1861 http://www.genome.jp/dbget-bin/www_bget?eco:b1861 KEGG_Orthology KO:K03550 http://www.genome.jp/dbget-bin/www_bget?KO:K03550 KEGG_Pathway ko03440 http://www.genome.jp/kegg-bin/show_pathway?ko03440 MINT MINT-1321234 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1321234 OMA VGYQVHC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VGYQVHC PDB 1BDX http://www.ebi.ac.uk/pdbe-srv/view/entry/1BDX PDB 1C7Y http://www.ebi.ac.uk/pdbe-srv/view/entry/1C7Y PDB 1CUK http://www.ebi.ac.uk/pdbe-srv/view/entry/1CUK PDB 1D8L http://www.ebi.ac.uk/pdbe-srv/view/entry/1D8L PDB 1HJP http://www.ebi.ac.uk/pdbe-srv/view/entry/1HJP PDBsum 1BDX http://www.ebi.ac.uk/pdbsum/1BDX PDBsum 1C7Y http://www.ebi.ac.uk/pdbsum/1C7Y PDBsum 1CUK http://www.ebi.ac.uk/pdbsum/1CUK PDBsum 1D8L http://www.ebi.ac.uk/pdbsum/1D8L PDBsum 1HJP http://www.ebi.ac.uk/pdbsum/1HJP PSORT swissprot:RUVA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RUVA_ECOLI PSORT-B swissprot:RUVA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RUVA_ECOLI PSORT2 swissprot:RUVA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RUVA_ECOLI Pfam PF01330 http://pfam.xfam.org/family/PF01330 Pfam PF07499 http://pfam.xfam.org/family/PF07499 Phobius swissprot:RUVA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RUVA_ECOLI PhylomeDB P0A809 http://phylomedb.org/?seqid=P0A809 ProteinModelPortal P0A809 http://www.proteinmodelportal.org/query/uniprot/P0A809 PubMed 10772859 http://www.ncbi.nlm.nih.gov/pubmed/10772859 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1885548 http://www.ncbi.nlm.nih.gov/pubmed/1885548 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 21219465 http://www.ncbi.nlm.nih.gov/pubmed/21219465 PubMed 2842314 http://www.ncbi.nlm.nih.gov/pubmed/2842314 PubMed 3279394 http://www.ncbi.nlm.nih.gov/pubmed/3279394 PubMed 8433990 http://www.ncbi.nlm.nih.gov/pubmed/8433990 PubMed 8832889 http://www.ncbi.nlm.nih.gov/pubmed/8832889 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9442895 http://www.ncbi.nlm.nih.gov/pubmed/9442895 PubMed 9493263 http://www.ncbi.nlm.nih.gov/pubmed/9493263 PubMed 9628481 http://www.ncbi.nlm.nih.gov/pubmed/9628481 RefSeq NP_416375 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416375 RefSeq WP_000580323 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000580323 SMART SM00278 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00278 SMR P0A809 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A809 STRING 511145.b1861 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1861&targetmode=cogs STRING COG0632 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0632&targetmode=cogs SUPFAM SSF46929 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46929 SUPFAM SSF47781 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47781 SUPFAM SSF50249 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50249 TIGRFAMs TIGR00084 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00084 UniProtKB RUVA_ECOLI http://www.uniprot.org/uniprot/RUVA_ECOLI UniProtKB-AC P0A809 http://www.uniprot.org/uniprot/P0A809 charge swissprot:RUVA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RUVA_ECOLI eggNOG COG0632 http://eggnogapi.embl.de/nog_data/html/tree/COG0632 eggNOG ENOG4105KA4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KA4 epestfind swissprot:RUVA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RUVA_ECOLI garnier swissprot:RUVA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RUVA_ECOLI helixturnhelix swissprot:RUVA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RUVA_ECOLI hmoment swissprot:RUVA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RUVA_ECOLI iep swissprot:RUVA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RUVA_ECOLI inforesidue swissprot:RUVA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RUVA_ECOLI octanol swissprot:RUVA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RUVA_ECOLI pepcoil swissprot:RUVA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RUVA_ECOLI pepdigest swissprot:RUVA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RUVA_ECOLI pepinfo swissprot:RUVA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RUVA_ECOLI pepnet swissprot:RUVA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RUVA_ECOLI pepstats swissprot:RUVA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RUVA_ECOLI pepwheel swissprot:RUVA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RUVA_ECOLI pepwindow swissprot:RUVA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RUVA_ECOLI sigcleave swissprot:RUVA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RUVA_ECOLI ## Database ID URL or Descriptions # AltName FLGL_ECOLI Hook-filament junction protein # BioGrid 4261022 6 # EcoGene EG11545 flgL # GO_component GO:0005576 extracellular region; IEA:UniProtKB-SubCell. # GO_component GO:0009424 bacterial-type flagellum hook; IEA:InterPro. # GO_function GO:0005198 structural molecule activity; IEA:InterPro. # GO_process GO:0071973 bacterial-type flagellum-dependent cell motility; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005576 extracellular region # GOslim_function GO:0005198 structural molecule activity # GOslim_process GO:0048870 cell motility # Gene3D 1.20.1330.10 -; 2. # IntAct P29744 7 # InterPro IPR001029 Flagellin_D0/D1 # InterPro IPR013384 Flagell_FlgL # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Pathway ko02040 Flagellar assembly # Organism FLGL_ECOLI Escherichia coli (strain K12) # PATRIC 32117407 VBIEscCol129921_1126 # PIR S44022 S44022 # Pfam PF00669 Flagellin_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FLGL_ECOLI Flagellar hook-associated protein 3 # RefSeq NP_415601 NC_000913.3 # RefSeq WP_001212782 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial flagellin family. {ECO 0000305}. # SUBCELLULAR LOCATION FLGL_ECOLI Secreted. Bacterial flagellum. # TIGRFAMs TIGR02550 flagell_flgL # eggNOG COG1344 LUCA # eggNOG ENOG4105DTJ Bacteria BLAST swissprot:FLGL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLGL_ECOLI BioCyc ECOL316407:JW1070-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1070-MONOMER BioCyc EcoCyc:EG11545-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11545-MONOMER COG COG1344 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1344 DOI 10.1006/jmbi.1994.1279 http://dx.doi.org/10.1006/jmbi.1994.1279 DOI 10.1016/0022-2836(92)90489-7 http://dx.doi.org/10.1016/0022-2836(92)90489-7 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U02514 http://www.ebi.ac.uk/ena/data/view/U02514 EMBL X67470 http://www.ebi.ac.uk/ena/data/view/X67470 EchoBASE EB1507 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1507 EcoGene EG11545 http://www.ecogene.org/geneInfo.php?eg_id=EG11545 EnsemblBacteria AAC74167 http://www.ensemblgenomes.org/id/AAC74167 EnsemblBacteria AAC74167 http://www.ensemblgenomes.org/id/AAC74167 EnsemblBacteria BAA35892 http://www.ensemblgenomes.org/id/BAA35892 EnsemblBacteria BAA35892 http://www.ensemblgenomes.org/id/BAA35892 EnsemblBacteria BAA35892 http://www.ensemblgenomes.org/id/BAA35892 EnsemblBacteria b1083 http://www.ensemblgenomes.org/id/b1083 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005576 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576 GO_component GO:0009424 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009424 GO_function GO:0005198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005198 GO_process GO:0071973 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071973 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005576 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576 GOslim_function GO:0005198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005198 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 Gene3D 1.20.1330.10 http://www.cathdb.info/version/latest/superfamily/1.20.1330.10 GeneID 945646 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945646 HOGENOM HOG000265587 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000265587&db=HOGENOM6 InParanoid P29744 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P29744 IntAct P29744 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P29744* InterPro IPR001029 http://www.ebi.ac.uk/interpro/entry/IPR001029 InterPro IPR013384 http://www.ebi.ac.uk/interpro/entry/IPR013384 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW1070 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1070 KEGG_Gene eco:b1083 http://www.genome.jp/dbget-bin/www_bget?eco:b1083 KEGG_Orthology KO:K02397 http://www.genome.jp/dbget-bin/www_bget?KO:K02397 KEGG_Pathway ko02040 http://www.genome.jp/kegg-bin/show_pathway?ko02040 OMA TEYYQRQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TEYYQRQ PSORT swissprot:FLGL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLGL_ECOLI PSORT-B swissprot:FLGL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLGL_ECOLI PSORT2 swissprot:FLGL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLGL_ECOLI Pfam PF00669 http://pfam.xfam.org/family/PF00669 Phobius swissprot:FLGL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLGL_ECOLI PhylomeDB P29744 http://phylomedb.org/?seqid=P29744 ProteinModelPortal P29744 http://www.proteinmodelportal.org/query/uniprot/P29744 PubMed 1447789 http://www.ncbi.nlm.nih.gov/pubmed/1447789 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8158647 http://www.ncbi.nlm.nih.gov/pubmed/8158647 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415601 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415601 RefSeq WP_001212782 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001212782 SMR P29744 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P29744 STRING 511145.b1083 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1083&targetmode=cogs STRING COG1344 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1344&targetmode=cogs SWISS-2DPAGE P29744 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P29744 TIGRFAMs TIGR02550 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02550 UniProtKB FLGL_ECOLI http://www.uniprot.org/uniprot/FLGL_ECOLI UniProtKB-AC P29744 http://www.uniprot.org/uniprot/P29744 charge swissprot:FLGL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLGL_ECOLI eggNOG COG1344 http://eggnogapi.embl.de/nog_data/html/tree/COG1344 eggNOG ENOG4105DTJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DTJ epestfind swissprot:FLGL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLGL_ECOLI garnier swissprot:FLGL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLGL_ECOLI helixturnhelix swissprot:FLGL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLGL_ECOLI hmoment swissprot:FLGL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLGL_ECOLI iep swissprot:FLGL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLGL_ECOLI inforesidue swissprot:FLGL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLGL_ECOLI octanol swissprot:FLGL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLGL_ECOLI pepcoil swissprot:FLGL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLGL_ECOLI pepdigest swissprot:FLGL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLGL_ECOLI pepinfo swissprot:FLGL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLGL_ECOLI pepnet swissprot:FLGL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLGL_ECOLI pepstats swissprot:FLGL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLGL_ECOLI pepwheel swissprot:FLGL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLGL_ECOLI pepwindow swissprot:FLGL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLGL_ECOLI sigcleave swissprot:FLGL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLGL_ECOLI ## Database ID URL or Descriptions # AltName FLIA_ECOLI Sigma-27 # AltName RNA polymerase sigma factor for flagellar operon {ECO:0000255|HAMAP-Rule MF_00962} # AltName Sigma F {ECO:0000255|HAMAP-Rule MF_00962} # AltName Sigma-28 {ECO:0000255|HAMAP-Rule MF_00962} # BioGrid 4259656 28 # DISRUPTION PHENOTYPE Mutants have poor biofilms (decrease in biomass, surface coverage and mean thickness). {ECO:0000269|PubMed 16397770}. # DOMAIN FLIA_ECOLI The sigma-70 factor domain-2 mediates sequence-specific interaction with the -10 element in promoter DNA, and plays an important role in melting the double-stranded DNA and the formation of the transcription bubble. The sigma-70 factor domain- 2 mediates interaction with the RNA polymerase subunits RpoB and RpoC (By similarity). {ECO 0000250}. # DOMAIN FLIA_ECOLI The sigma-70 factor domain-4 contains a helix-turn-helix (H-T-H) motif that mediates interaction with the -35 element in promoter DNA. The domain also mediates interaction with the RNA polymerase subunit RpoA (By similarity). {ECO 0000250}. # EcoGene EG11355 fliA # FUNCTION FLIA_ECOLI Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes. {ECO 0000255|HAMAP-Rule MF_00962, ECO 0000269|PubMed 2644646, ECO 0000269|PubMed 3536871, ECO 0000269|PubMed 7590326, ECO 0000269|PubMed 8866483}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_function GO:0003899 DNA-directed RNA polymerase activity; IEA:InterPro. # GO_function GO:0016987 sigma factor activity; IEA:UniProtKB-HAMAP. # GO_process GO:0001123 transcription initiation from bacterial-type RNA polymerase promoter; IEA:UniProtKB-HAMAP. # GO_process GO:0006355 regulation of transcription, DNA-templated; IBA:GO_Central. # GO_process GO:0030435 sporulation resulting in formation of a cellular spore; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0000988 transcription factor activity, protein binding # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0030154 cell differentiation # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0048646 anatomical structure formation involved in morphogenesis # Gene3D 1.10.10.10 -; 2. # HAMAP MF_00962 Sigma70_FliA # INTERACTION FLIA_ECOLI P0AEM4 flgM; NbExp=4; IntAct=EBI-549807, EBI-1121952; # IntAct P0AEM6 21 # InterPro IPR000943 RNA_pol_sigma70 # InterPro IPR007624 RNA_pol_sigma70_r3 # InterPro IPR007627 RNA_pol_sigma70_r2 # InterPro IPR007630 RNA_pol_sigma70_r4 # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR012845 RNA_pol_sigma_FliA_WhiG # InterPro IPR013324 RNA_pol_sigma_r3_r4 # InterPro IPR013325 RNA_pol_sigma_r2 # InterPro IPR014284 RNA_pol_sigma-70_dom # InterPro IPR016263 RNA_pol_sigma_factor # InterPro IPR028617 Sigma70_FliA # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Brite ko03021 Transcription machinery # KEGG_Pathway ko02020 Two-component system # KEGG_Pathway ko05111 Vibrio cholerae pathogenic cycle # MISCELLANEOUS The distinguishing feature of FliA promoters is a long -10 region (GCCGATAA). The upstream GC constitutes an extended -10 motif and is recognized by Arg-91 (PubMed:19400790). {ECO 0000305|PubMed:19400790}. # Organism FLIA_ECOLI Escherichia coli (strain K12) # PATRIC 32119179 VBIEscCol129921_2004 # PIR JC4346 JC4346 # PIRSF PIRSF000770 RNA_pol_sigma-SigE/K # PRINTS PR00046 SIGMA70FCT # PROSITE PS00715 SIGMA70_1 # PROSITE PS00716 SIGMA70_2 # Pfam PF04539 Sigma70_r3 # Pfam PF04542 Sigma70_r2 # Pfam PF04545 Sigma70_r4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RNA polymerase sigma factor FliA {ECO:0000255|HAMAP-Rule MF_00962} # RefSeq NP_416432 NC_000913.3 # RefSeq WP_001087467 NZ_LN832404.1 # SIMILARITY Belongs to the sigma-70 factor family. FliA subfamily. {ECO:0000255|HAMAP-Rule MF_00962}. # SUBCELLULAR LOCATION FLIA_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00962}. # SUPFAM SSF88659 SSF88659; 2 # SUPFAM SSF88946 SSF88946 # TIGRFAMs TIGR02479 FliA_WhiG # TIGRFAMs TIGR02937 sigma70-ECF # eggNOG COG1191 LUCA # eggNOG ENOG4105DN4 Bacteria BLAST swissprot:FLIA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLIA_ECOLI BioCyc ECOL316407:JW1907-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1907-MONOMER BioCyc EcoCyc:EG11355-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11355-MONOMER BioCyc MetaCyc:EG11355-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11355-MONOMER COG COG1191 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1191 DIP DIP-47959N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47959N DOI 10.1007/s00253-005-0263-8 http://dx.doi.org/10.1007/s00253-005-0263-8 DOI 10.1016/0378-1119(95)00480-T http://dx.doi.org/10.1016/0378-1119(95)00480-T DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.86.3.830 http://dx.doi.org/10.1073/pnas.86.3.830 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1111/j.1365-2958.1996.tb02569.x http://dx.doi.org/10.1111/j.1365-2958.1996.tb02569.x DOI 10.1111/j.1365-2958.2009.06691.x http://dx.doi.org/10.1111/j.1365-2958.2009.06691.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L36677 http://www.ebi.ac.uk/ena/data/view/L36677 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18539 http://www.ebi.ac.uk/ena/data/view/U18539 EchoBASE EB1330 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1330 EcoGene EG11355 http://www.ecogene.org/geneInfo.php?eg_id=EG11355 EnsemblBacteria AAC74989 http://www.ensemblgenomes.org/id/AAC74989 EnsemblBacteria AAC74989 http://www.ensemblgenomes.org/id/AAC74989 EnsemblBacteria BAA15742 http://www.ensemblgenomes.org/id/BAA15742 EnsemblBacteria BAA15742 http://www.ensemblgenomes.org/id/BAA15742 EnsemblBacteria BAA15742 http://www.ensemblgenomes.org/id/BAA15742 EnsemblBacteria b1922 http://www.ensemblgenomes.org/id/b1922 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0003899 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003899 GO_function GO:0016987 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016987 GO_process GO:0001123 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001123 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0030435 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030435 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0000988 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000988 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0030154 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0048646 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048646 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 948824 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948824 HAMAP MF_00962 http://hamap.expasy.org/unirule/MF_00962 HOGENOM HOG000270271 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000270271&db=HOGENOM6 InParanoid P0AEM6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEM6 IntAct P0AEM6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEM6* InterPro IPR000943 http://www.ebi.ac.uk/interpro/entry/IPR000943 InterPro IPR007624 http://www.ebi.ac.uk/interpro/entry/IPR007624 InterPro IPR007627 http://www.ebi.ac.uk/interpro/entry/IPR007627 InterPro IPR007630 http://www.ebi.ac.uk/interpro/entry/IPR007630 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR012845 http://www.ebi.ac.uk/interpro/entry/IPR012845 InterPro IPR013324 http://www.ebi.ac.uk/interpro/entry/IPR013324 InterPro IPR013325 http://www.ebi.ac.uk/interpro/entry/IPR013325 InterPro IPR014284 http://www.ebi.ac.uk/interpro/entry/IPR014284 InterPro IPR016263 http://www.ebi.ac.uk/interpro/entry/IPR016263 InterPro IPR028617 http://www.ebi.ac.uk/interpro/entry/IPR028617 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Brite ko03021 http://www.genome.jp/dbget-bin/www_bget?ko03021 KEGG_Gene ecj:JW1907 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1907 KEGG_Gene eco:b1922 http://www.genome.jp/dbget-bin/www_bget?eco:b1922 KEGG_Orthology KO:K02405 http://www.genome.jp/dbget-bin/www_bget?KO:K02405 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 KEGG_Pathway ko05111 http://www.genome.jp/kegg-bin/show_pathway?ko05111 MINT MINT-1250982 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1250982 OMA HEEANPL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HEEANPL PRINTS PR00046 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00046 PROSITE PS00715 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00715 PROSITE PS00716 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00716 PSORT swissprot:FLIA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLIA_ECOLI PSORT-B swissprot:FLIA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLIA_ECOLI PSORT2 swissprot:FLIA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLIA_ECOLI Pfam PF04539 http://pfam.xfam.org/family/PF04539 Pfam PF04542 http://pfam.xfam.org/family/PF04542 Pfam PF04545 http://pfam.xfam.org/family/PF04545 Phobius swissprot:FLIA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLIA_ECOLI PhylomeDB P0AEM6 http://phylomedb.org/?seqid=P0AEM6 ProteinModelPortal P0AEM6 http://www.proteinmodelportal.org/query/uniprot/P0AEM6 PubMed 16397770 http://www.ncbi.nlm.nih.gov/pubmed/16397770 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19400790 http://www.ncbi.nlm.nih.gov/pubmed/19400790 PubMed 2644646 http://www.ncbi.nlm.nih.gov/pubmed/2644646 PubMed 3536871 http://www.ncbi.nlm.nih.gov/pubmed/3536871 PubMed 7590326 http://www.ncbi.nlm.nih.gov/pubmed/7590326 PubMed 8550423 http://www.ncbi.nlm.nih.gov/pubmed/8550423 PubMed 8866483 http://www.ncbi.nlm.nih.gov/pubmed/8866483 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416432 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416432 RefSeq WP_001087467 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001087467 SMR P0AEM6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEM6 STRING 511145.b1922 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1922&targetmode=cogs STRING COG1191 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1191&targetmode=cogs SUPFAM SSF88659 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF88659 SUPFAM SSF88946 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF88946 TIGRFAMs TIGR02479 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02479 TIGRFAMs TIGR02937 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02937 UniProtKB FLIA_ECOLI http://www.uniprot.org/uniprot/FLIA_ECOLI UniProtKB-AC P0AEM6 http://www.uniprot.org/uniprot/P0AEM6 charge swissprot:FLIA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLIA_ECOLI eggNOG COG1191 http://eggnogapi.embl.de/nog_data/html/tree/COG1191 eggNOG ENOG4105DN4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DN4 epestfind swissprot:FLIA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLIA_ECOLI garnier swissprot:FLIA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLIA_ECOLI helixturnhelix swissprot:FLIA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLIA_ECOLI hmoment swissprot:FLIA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLIA_ECOLI iep swissprot:FLIA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLIA_ECOLI inforesidue swissprot:FLIA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLIA_ECOLI octanol swissprot:FLIA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLIA_ECOLI pepcoil swissprot:FLIA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLIA_ECOLI pepdigest swissprot:FLIA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLIA_ECOLI pepinfo swissprot:FLIA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLIA_ECOLI pepnet swissprot:FLIA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLIA_ECOLI pepstats swissprot:FLIA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLIA_ECOLI pepwheel swissprot:FLIA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLIA_ECOLI pepwindow swissprot:FLIA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLIA_ECOLI sigcleave swissprot:FLIA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLIA_ECOLI ## Database ID URL or Descriptions # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # Organism YGIA_ECOLI Escherichia coli (strain K12) # PIR S11458 S11458 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGIA_ECOLI Putative uncharacterized protein YgiA # RefSeq WP_001701108 NZ_LN832404.1 BLAST swissprot:YGIA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGIA_ECOLI BioCyc ECOL316407:JW5889-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5889-MONOMER BioCyc EcoCyc:EG11163-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11163-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/18.18.5547 http://dx.doi.org/10.1093/nar/18.18.5547 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EMBL X54049 http://www.ebi.ac.uk/ena/data/view/X54049 EnsemblBacteria BAE77092 http://www.ensemblgenomes.org/id/BAE77092 EnsemblBacteria BAE77092 http://www.ensemblgenomes.org/id/BAE77092 EnsemblBacteria BAE77092 http://www.ensemblgenomes.org/id/BAE77092 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv KEGG_Gene ecj:JW5889 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5889 OMA MAGFQPR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MAGFQPR PSORT swissprot:YGIA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGIA_ECOLI PSORT-B swissprot:YGIA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGIA_ECOLI PSORT2 swissprot:YGIA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGIA_ECOLI Phobius swissprot:YGIA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGIA_ECOLI ProteinModelPortal Q79CP2 http://www.proteinmodelportal.org/query/uniprot/Q79CP2 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2216730 http://www.ncbi.nlm.nih.gov/pubmed/2216730 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001701108 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001701108 STRING 316407.85675839 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85675839&targetmode=cogs UniProtKB YGIA_ECOLI http://www.uniprot.org/uniprot/YGIA_ECOLI UniProtKB-AC Q79CP2 http://www.uniprot.org/uniprot/Q79CP2 charge swissprot:YGIA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGIA_ECOLI epestfind swissprot:YGIA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGIA_ECOLI garnier swissprot:YGIA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGIA_ECOLI helixturnhelix swissprot:YGIA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGIA_ECOLI hmoment swissprot:YGIA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGIA_ECOLI iep swissprot:YGIA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGIA_ECOLI inforesidue swissprot:YGIA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGIA_ECOLI octanol swissprot:YGIA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGIA_ECOLI pepcoil swissprot:YGIA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGIA_ECOLI pepdigest swissprot:YGIA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGIA_ECOLI pepinfo swissprot:YGIA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGIA_ECOLI pepnet swissprot:YGIA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGIA_ECOLI pepstats swissprot:YGIA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGIA_ECOLI pepwheel swissprot:YGIA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGIA_ECOLI pepwindow swissprot:YGIA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGIA_ECOLI sigcleave swissprot:YGIA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGIA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262253 11 # EcoGene EG14284 ypjF # FUNCTION YPJF_ECOLI Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures. Might be inactivated by putative antitoxin YfjZ. {ECO 0000269|PubMed 14594833}. # INTERACTION YPJF_ECOLI P0AAY6 ybjN; NbExp=3; IntAct=EBI-9134503, EBI-9138440; # IntAct Q46953 12 # InterPro IPR009610 CbtA_toxin # Organism YPJF_ECOLI Escherichia coli (strain K12) # PATRIC 32120687 VBIEscCol129921_2742 # PIR T08657 T08657 # Pfam PF06755 CbtA_toxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YPJF_ECOLI Probable toxin YpjF # RefSeq NP_417133 NC_000913.3 # RefSeq WP_001094400 NZ_LN832404.1 # SIMILARITY Belongs to the CbtA/YkfI/YpjF toxin family. {ECO 0000305}. # eggNOG ENOG4108X3P Bacteria # eggNOG ENOG4111PBJ LUCA BLAST swissprot:YPJF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YPJF_ECOLI BioCyc ECOL316407:JW2627-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2627-MONOMER BioCyc EcoCyc:G7381-MONOMER http://biocyc.org/getid?id=EcoCyc:G7381-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.185.22.6600-6608.2003 http://dx.doi.org/10.1128/JB.185.22.6600-6608.2003 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36840 http://www.ebi.ac.uk/ena/data/view/U36840 EchoBASE EB4032 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4032 EcoGene EG14284 http://www.ecogene.org/geneInfo.php?eg_id=EG14284 EnsemblBacteria AAC75694 http://www.ensemblgenomes.org/id/AAC75694 EnsemblBacteria AAC75694 http://www.ensemblgenomes.org/id/AAC75694 EnsemblBacteria BAE76774 http://www.ensemblgenomes.org/id/BAE76774 EnsemblBacteria BAE76774 http://www.ensemblgenomes.org/id/BAE76774 EnsemblBacteria BAE76774 http://www.ensemblgenomes.org/id/BAE76774 EnsemblBacteria b2646 http://www.ensemblgenomes.org/id/b2646 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947131 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947131 HOGENOM HOG000124769 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000124769&db=HOGENOM6 IntAct Q46953 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46953* InterPro IPR009610 http://www.ebi.ac.uk/interpro/entry/IPR009610 KEGG_Gene ecj:JW2627 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2627 KEGG_Gene eco:b2646 http://www.genome.jp/dbget-bin/www_bget?eco:b2646 OMA YLRAVNI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YLRAVNI PSORT swissprot:YPJF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YPJF_ECOLI PSORT-B swissprot:YPJF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YPJF_ECOLI PSORT2 swissprot:YPJF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YPJF_ECOLI Pfam PF06755 http://pfam.xfam.org/family/PF06755 Phobius swissprot:YPJF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YPJF_ECOLI PhylomeDB Q46953 http://phylomedb.org/?seqid=Q46953 ProteinModelPortal Q46953 http://www.proteinmodelportal.org/query/uniprot/Q46953 PubMed 14594833 http://www.ncbi.nlm.nih.gov/pubmed/14594833 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417133 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417133 RefSeq WP_001094400 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001094400 STRING 511145.b2646 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2646&targetmode=cogs UniProtKB YPJF_ECOLI http://www.uniprot.org/uniprot/YPJF_ECOLI UniProtKB-AC Q46953 http://www.uniprot.org/uniprot/Q46953 charge swissprot:YPJF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YPJF_ECOLI eggNOG ENOG4108X3P http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108X3P eggNOG ENOG4111PBJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111PBJ epestfind swissprot:YPJF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YPJF_ECOLI garnier swissprot:YPJF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YPJF_ECOLI helixturnhelix swissprot:YPJF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YPJF_ECOLI hmoment swissprot:YPJF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YPJF_ECOLI iep swissprot:YPJF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YPJF_ECOLI inforesidue swissprot:YPJF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YPJF_ECOLI octanol swissprot:YPJF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YPJF_ECOLI pepcoil swissprot:YPJF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YPJF_ECOLI pepdigest swissprot:YPJF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YPJF_ECOLI pepinfo swissprot:YPJF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YPJF_ECOLI pepnet swissprot:YPJF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YPJF_ECOLI pepstats swissprot:YPJF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YPJF_ECOLI pepwheel swissprot:YPJF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YPJF_ECOLI pepwindow swissprot:YPJF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YPJF_ECOLI sigcleave swissprot:YPJF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YPJF_ECOLI ## Database ID URL or Descriptions # BioGrid 4263347 10 # EcoGene EG13656 ybeZ # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.300 -; 1. # IntAct P0A9K3 54 # InterPro IPR003714 PhoH # InterPro IPR027417 P-loop_NTPase # Organism PHOL_ECOLI Escherichia coli (strain K12) # PATRIC 32116509 VBIEscCol129921_0694 # PIR B64801 B64801 # Pfam PF02562 PhoH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PHOL_ECOLI PhoH-like protein # RefSeq NP_415193 NC_000913.3 # RefSeq WP_001018040 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40862.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA35315.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the PhoH family. {ECO 0000305}. # SUBCELLULAR LOCATION PHOL_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF52540 SSF52540 # eggNOG COG1702 LUCA # eggNOG ENOG4105C9A Bacteria BLAST swissprot:PHOL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PHOL_ECOLI BioCyc ECOL316407:JW0657-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0657-MONOMER BioCyc EcoCyc:G6363-MONOMER http://biocyc.org/getid?id=EcoCyc:G6363-MONOMER COG COG1702 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1702 DIP DIP-47879N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47879N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB3420 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3420 EcoGene EG13656 http://www.ecogene.org/geneInfo.php?eg_id=EG13656 EnsemblBacteria AAC73761 http://www.ensemblgenomes.org/id/AAC73761 EnsemblBacteria AAC73761 http://www.ensemblgenomes.org/id/AAC73761 EnsemblBacteria BAA35315 http://www.ensemblgenomes.org/id/BAA35315 EnsemblBacteria BAA35315 http://www.ensemblgenomes.org/id/BAA35315 EnsemblBacteria BAA35315 http://www.ensemblgenomes.org/id/BAA35315 EnsemblBacteria b0660 http://www.ensemblgenomes.org/id/b0660 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948044 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948044 HOGENOM HOG000015043 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000015043&db=HOGENOM6 InParanoid P0A9K3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9K3 IntAct P0A9K3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9K3* InterPro IPR003714 http://www.ebi.ac.uk/interpro/entry/IPR003714 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Gene ecj:JW0657 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0657 KEGG_Gene eco:b0660 http://www.genome.jp/dbget-bin/www_bget?eco:b0660 KEGG_Orthology KO:K06217 http://www.genome.jp/dbget-bin/www_bget?KO:K06217 MINT MINT-1218508 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1218508 OMA ANLCGQF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ANLCGQF PSORT swissprot:PHOL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PHOL_ECOLI PSORT-B swissprot:PHOL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PHOL_ECOLI PSORT2 swissprot:PHOL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PHOL_ECOLI Pfam PF02562 http://pfam.xfam.org/family/PF02562 Phobius swissprot:PHOL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PHOL_ECOLI PhylomeDB P0A9K3 http://phylomedb.org/?seqid=P0A9K3 ProteinModelPortal P0A9K3 http://www.proteinmodelportal.org/query/uniprot/P0A9K3 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415193 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415193 RefSeq WP_001018040 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001018040 SMR P0A9K3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9K3 STRING 511145.b0660 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0660&targetmode=cogs STRING COG1702 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1702&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB PHOL_ECOLI http://www.uniprot.org/uniprot/PHOL_ECOLI UniProtKB-AC P0A9K3 http://www.uniprot.org/uniprot/P0A9K3 charge swissprot:PHOL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PHOL_ECOLI eggNOG COG1702 http://eggnogapi.embl.de/nog_data/html/tree/COG1702 eggNOG ENOG4105C9A http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C9A epestfind swissprot:PHOL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PHOL_ECOLI garnier swissprot:PHOL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PHOL_ECOLI helixturnhelix swissprot:PHOL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PHOL_ECOLI hmoment swissprot:PHOL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PHOL_ECOLI iep swissprot:PHOL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PHOL_ECOLI inforesidue swissprot:PHOL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PHOL_ECOLI octanol swissprot:PHOL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PHOL_ECOLI pepcoil swissprot:PHOL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PHOL_ECOLI pepdigest swissprot:PHOL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PHOL_ECOLI pepinfo swissprot:PHOL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PHOL_ECOLI pepnet swissprot:PHOL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PHOL_ECOLI pepstats swissprot:PHOL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PHOL_ECOLI pepwheel swissprot:PHOL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PHOL_ECOLI pepwindow swissprot:PHOL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PHOL_ECOLI sigcleave swissprot:PHOL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PHOL_ECOLI ## Database ID URL or Descriptions # AltName PAAD_ECOLI 1,2-phenylacetyl-CoA monooxygenase, subunit D # BioGrid 4262886 118 # EcoGene EG13738 paaD # FUNCTION PAAD_ECOLI Possible component of 1,2-phenylacetyl-CoA epoxidase multicomponent enzyme system which catalyzes the reduction of phenylacetyl-CoA (PA-CoA) to form 1,2-epoxyphenylacetyl-CoA. The subunit D may have a function related to the maturation of the monooxygenase complex, rather than direct involvement in catalysis. PaaD could assist either in maturation of PaaE or PaaA. {ECO 0000269|PubMed 16997993, ECO 0000269|PubMed 9748275}. # GO_process GO:0010124 phenylacetate catabolic process; IMP:UniProtKB. # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # INDUCTION PAAD_ECOLI Activated by cAMP receptor protein (CRP), integration host factor (IHF) and by phenylacetyl-coenzyme A (PA-CoA) that prevents PaaX from binding its target sequences. Inhibited by PaaX. {ECO 0000269|PubMed 10766858, ECO 0000269|PubMed 9748275}. # IntAct P76080 4 # InterPro IPR002744 DUF59 # InterPro IPR011883 PA_CoA_Oase4 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko00360 Phenylalanine metabolism # MISCELLANEOUS PAAD_ECOLI PaaD component is not essential for the reaction in vitro. # Organism PAAD_ECOLI Escherichia coli (strain K12) # PATHWAY PAAD_ECOLI Aromatic compound metabolism; phenylacetate degradation. # PATRIC 32118068 VBIEscCol129921_1454 # PIR B64890 B64890 # Pfam PF01883 DUF59 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PAAD_ECOLI Putative 1,2-phenylacetyl-CoA epoxidase, subunit D # RefSeq NP_415909 NC_000913.3 # RefSeq WP_001189201 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA66093.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SUBUNIT Monomer. {ECO:0000269|PubMed 21247899}. # TIGRFAMs TIGR02159 PA_CoA_Oxy4 # eggNOG COG2151 LUCA # eggNOG ENOG4108ZA2 Bacteria BLAST swissprot:PAAD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PAAD_ECOLI BioCyc ECOL316407:JW5217-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5217-MONOMER BioCyc EcoCyc:G6712-MONOMER http://biocyc.org/getid?id=EcoCyc:G6712-MONOMER COG COG2151 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2151 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.273.40.25974 http://dx.doi.org/10.1074/jbc.273.40.25974 DOI 10.1074/jbc.275.16.12214 http://dx.doi.org/10.1074/jbc.275.16.12214 DOI 10.1074/jbc.M110.194423 http://dx.doi.org/10.1074/jbc.M110.194423 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AEM.01550-06 http://dx.doi.org/10.1128/AEM.01550-06 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X97452 http://www.ebi.ac.uk/ena/data/view/X97452 EchoBASE EB3501 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3501 EcoGene EG13738 http://www.ecogene.org/geneInfo.php?eg_id=EG13738 EnsemblBacteria AAC74473 http://www.ensemblgenomes.org/id/AAC74473 EnsemblBacteria AAC74473 http://www.ensemblgenomes.org/id/AAC74473 EnsemblBacteria BAE76426 http://www.ensemblgenomes.org/id/BAE76426 EnsemblBacteria BAE76426 http://www.ensemblgenomes.org/id/BAE76426 EnsemblBacteria BAE76426 http://www.ensemblgenomes.org/id/BAE76426 EnsemblBacteria b1391 http://www.ensemblgenomes.org/id/b1391 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0010124 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010124 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 945959 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945959 HOGENOM HOG000249723 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000249723&db=HOGENOM6 InParanoid P76080 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76080 IntAct P76080 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76080* InterPro IPR002744 http://www.ebi.ac.uk/interpro/entry/IPR002744 InterPro IPR011883 http://www.ebi.ac.uk/interpro/entry/IPR011883 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW5217 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5217 KEGG_Gene eco:b1391 http://www.genome.jp/dbget-bin/www_bget?eco:b1391 KEGG_Orthology KO:K02612 http://www.genome.jp/dbget-bin/www_bget?KO:K02612 KEGG_Pathway ko00360 http://www.genome.jp/kegg-bin/show_pathway?ko00360 KEGG_Reaction rn:R09838 http://www.genome.jp/dbget-bin/www_bget?rn:R09838 PSORT swissprot:PAAD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PAAD_ECOLI PSORT-B swissprot:PAAD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PAAD_ECOLI PSORT2 swissprot:PAAD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PAAD_ECOLI Pfam PF01883 http://pfam.xfam.org/family/PF01883 Phobius swissprot:PAAD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PAAD_ECOLI PhylomeDB P76080 http://phylomedb.org/?seqid=P76080 ProteinModelPortal P76080 http://www.proteinmodelportal.org/query/uniprot/P76080 PubMed 10766858 http://www.ncbi.nlm.nih.gov/pubmed/10766858 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16997993 http://www.ncbi.nlm.nih.gov/pubmed/16997993 PubMed 21247899 http://www.ncbi.nlm.nih.gov/pubmed/21247899 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9748275 http://www.ncbi.nlm.nih.gov/pubmed/9748275 RefSeq NP_415909 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415909 RefSeq WP_001189201 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001189201 STRING 511145.b1391 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1391&targetmode=cogs STRING COG2151 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2151&targetmode=cogs TIGRFAMs TIGR02159 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02159 UniProtKB PAAD_ECOLI http://www.uniprot.org/uniprot/PAAD_ECOLI UniProtKB-AC P76080 http://www.uniprot.org/uniprot/P76080 charge swissprot:PAAD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PAAD_ECOLI eggNOG COG2151 http://eggnogapi.embl.de/nog_data/html/tree/COG2151 eggNOG ENOG4108ZA2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZA2 epestfind swissprot:PAAD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PAAD_ECOLI garnier swissprot:PAAD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PAAD_ECOLI helixturnhelix swissprot:PAAD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PAAD_ECOLI hmoment swissprot:PAAD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PAAD_ECOLI iep swissprot:PAAD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PAAD_ECOLI inforesidue swissprot:PAAD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PAAD_ECOLI octanol swissprot:PAAD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PAAD_ECOLI pepcoil swissprot:PAAD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PAAD_ECOLI pepdigest swissprot:PAAD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PAAD_ECOLI pepinfo swissprot:PAAD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PAAD_ECOLI pepnet swissprot:PAAD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PAAD_ECOLI pepstats swissprot:PAAD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PAAD_ECOLI pepwheel swissprot:PAAD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PAAD_ECOLI pepwindow swissprot:PAAD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PAAD_ECOLI sigcleave swissprot:PAAD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PAAD_ECOLI ## Database ID URL or Descriptions # BioGrid 4259110 129 # EcoGene EG11434 marA # FUNCTION MARA_ECOLI May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0000987 core promoter proximal region sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IBA:GO_Central. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IMP:EcoCyc. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.60 -; 2. # INDUCTION MARA_ECOLI By various antibiotics or by sodium salicylate. # InterPro IPR009057 Homeodomain-like # InterPro IPR018060 HTH_AraC # InterPro IPR018062 HTH_AraC-typ_CS # KEGG_Brite ko03000 Transcription factors # Organism MARA_ECOLI Escherichia coli (strain K12) # PATRIC 32118360 VBIEscCol129921_1600 # PDB 1BL0 X-ray; 2.30 A; A=1-127 # PDB 1XS9 NMR; -; A=1-127 # PIR B47072 B47072 # PROSITE PS00041 HTH_ARAC_FAMILY_1 # PROSITE PS01124 HTH_ARAC_FAMILY_2 # Pfam PF12833 HTH_18 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MARA_ECOLI Multiple antibiotic resistance protein MarA # RefSeq NP_416048 NC_000913.3 # RefSeq WP_000091199 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAC16395.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Contains 1 HTH araC/xylS-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00593}. # SMART SM00342 HTH_ARAC # SUBUNIT MARA_ECOLI Monomer. # SUPFAM SSF46689 SSF46689; 2 # eggNOG ENOG4108XW0 Bacteria # eggNOG ENOG4111IUP LUCA BLAST swissprot:MARA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MARA_ECOLI BioCyc ECOL316407:JW5249-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5249-MONOMER BioCyc EcoCyc:PD00365 http://biocyc.org/getid?id=EcoCyc:PD00365 COG COG2207 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2207 DIP DIP-48136N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48136N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.95.18.10413 http://dx.doi.org/10.1073/pnas.95.18.10413 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L06966 http://www.ebi.ac.uk/ena/data/view/L06966 EMBL M96235 http://www.ebi.ac.uk/ena/data/view/M96235 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1404 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1404 EcoGene EG11434 http://www.ecogene.org/geneInfo.php?eg_id=EG11434 EnsemblBacteria AAC74604 http://www.ensemblgenomes.org/id/AAC74604 EnsemblBacteria AAC74604 http://www.ensemblgenomes.org/id/AAC74604 EnsemblBacteria BAA15221 http://www.ensemblgenomes.org/id/BAA15221 EnsemblBacteria BAA15221 http://www.ensemblgenomes.org/id/BAA15221 EnsemblBacteria BAA15221 http://www.ensemblgenomes.org/id/BAA15221 EnsemblBacteria b1531 http://www.ensemblgenomes.org/id/b1531 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000987 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000987 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 GeneID 947613 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947613 HOGENOM HOG000120762 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120762&db=HOGENOM6 InParanoid P0ACH5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACH5 IntAct P0ACH5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACH5* InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR018060 http://www.ebi.ac.uk/interpro/entry/IPR018060 InterPro IPR018062 http://www.ebi.ac.uk/interpro/entry/IPR018062 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW5249 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5249 KEGG_Gene eco:b1531 http://www.genome.jp/dbget-bin/www_bget?eco:b1531 KEGG_Orthology KO:K13632 http://www.genome.jp/dbget-bin/www_bget?KO:K13632 MINT MINT-1251059 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1251059 OMA ATFTRIF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ATFTRIF PDB 1BL0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1BL0 PDB 1XS9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1XS9 PDBsum 1BL0 http://www.ebi.ac.uk/pdbsum/1BL0 PDBsum 1XS9 http://www.ebi.ac.uk/pdbsum/1XS9 PROSITE PS00041 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00041 PROSITE PS01124 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01124 PSORT swissprot:MARA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MARA_ECOLI PSORT-B swissprot:MARA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MARA_ECOLI PSORT2 swissprot:MARA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MARA_ECOLI Pfam PF12833 http://pfam.xfam.org/family/PF12833 Phobius swissprot:MARA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MARA_ECOLI PhylomeDB P0ACH5 http://phylomedb.org/?seqid=P0ACH5 ProteinModelPortal P0ACH5 http://www.proteinmodelportal.org/query/uniprot/P0ACH5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8383113 http://www.ncbi.nlm.nih.gov/pubmed/8383113 PubMed 8491710 http://www.ncbi.nlm.nih.gov/pubmed/8491710 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9724717 http://www.ncbi.nlm.nih.gov/pubmed/9724717 RefSeq NP_416048 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416048 RefSeq WP_000091199 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000091199 SMART SM00342 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00342 SMR P0ACH5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACH5 STRING 511145.b1531 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1531&targetmode=cogs STRING COG2207 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2207&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 UniProtKB MARA_ECOLI http://www.uniprot.org/uniprot/MARA_ECOLI UniProtKB-AC P0ACH5 http://www.uniprot.org/uniprot/P0ACH5 charge swissprot:MARA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MARA_ECOLI eggNOG ENOG4108XW0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108XW0 eggNOG ENOG4111IUP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111IUP epestfind swissprot:MARA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MARA_ECOLI garnier swissprot:MARA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MARA_ECOLI helixturnhelix swissprot:MARA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MARA_ECOLI hmoment swissprot:MARA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MARA_ECOLI iep swissprot:MARA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MARA_ECOLI inforesidue swissprot:MARA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MARA_ECOLI octanol swissprot:MARA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MARA_ECOLI pepcoil swissprot:MARA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MARA_ECOLI pepdigest swissprot:MARA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MARA_ECOLI pepinfo swissprot:MARA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MARA_ECOLI pepnet swissprot:MARA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MARA_ECOLI pepstats swissprot:MARA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MARA_ECOLI pepwheel swissprot:MARA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MARA_ECOLI pepwindow swissprot:MARA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MARA_ECOLI sigcleave swissprot:MARA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MARA_ECOLI ## Database ID URL or Descriptions # AltName CCMB_ECOLI Cytochrome c-type biogenesis protein CcmB # BioGrid 4260485 8 # EcoGene EG12058 ccmB # FUNCTION CCMB_ECOLI Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; NAS:EcoCyc. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IDA:EcoCyc. # GO_function GO:0015232 heme transporter activity; IEA:InterPro. # GO_function GO:0042623 ATPase activity, coupled; IDA:EcoCyc. # GO_process GO:0017004 cytochrome complex assembly; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016887 ATPase activity # GOslim_process GO:0006461 protein complex assembly # IntAct P0ABL8 9 # InterPro IPR003544 Cyt_c_biogenesis_CcmB # InterPro IPR026031 Cyt_c_CcmB_bac # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00259 Heme transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism CCMB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30070:SF1 PTHR30070:SF1 # PATRIC 32119759 VBIEscCol129921_2289 # PIR F64989 F64989 # PIRSF PIRSF002764 CcmB # PRINTS PR01414 CCMBBIOGNSIS # Pfam PF03379 CcmB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CCMB_ECOLI Heme exporter protein B # RefSeq NP_416704 NC_000913.3 # SIMILARITY Belongs to the CcmB/CycW/HelB family. {ECO 0000305}. # SUBCELLULAR LOCATION CCMB_ECOLI Cell inner membrane; Multi-pass membrane protein. # TIGRFAMs TIGR01190 ccmB # eggNOG COG2386 LUCA # eggNOG ENOG4105CA5 Bacteria BLAST swissprot:CCMB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CCMB_ECOLI BioCyc ECOL316407:JW2188-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2188-MONOMER BioCyc EcoCyc:CCMB-MONOMER http://biocyc.org/getid?id=EcoCyc:CCMB-MONOMER BioCyc MetaCyc:CCMB-MONOMER http://biocyc.org/getid?id=MetaCyc:CCMB-MONOMER COG COG2386 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2386 DIP DIP-48046N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48046N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00008 http://www.ebi.ac.uk/ena/data/view/U00008 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1988 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1988 EcoGene EG12058 http://www.ecogene.org/geneInfo.php?eg_id=EG12058 EnsemblBacteria AAC75260 http://www.ensemblgenomes.org/id/AAC75260 EnsemblBacteria AAC75260 http://www.ensemblgenomes.org/id/AAC75260 EnsemblBacteria BAE76663 http://www.ensemblgenomes.org/id/BAE76663 EnsemblBacteria BAE76663 http://www.ensemblgenomes.org/id/BAE76663 EnsemblBacteria BAE76663 http://www.ensemblgenomes.org/id/BAE76663 EnsemblBacteria b2200 http://www.ensemblgenomes.org/id/b2200 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0015232 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015232 GO_function GO:0042623 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042623 GO_process GO:0017004 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017004 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GeneID 946692 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946692 HOGENOM HOG000274626 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000274626&db=HOGENOM6 InParanoid P0ABL8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABL8 IntAct P0ABL8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABL8* InterPro IPR003544 http://www.ebi.ac.uk/interpro/entry/IPR003544 InterPro IPR026031 http://www.ebi.ac.uk/interpro/entry/IPR026031 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2188 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2188 KEGG_Gene eco:b2200 http://www.genome.jp/dbget-bin/www_bget?eco:b2200 KEGG_Orthology KO:K02194 http://www.genome.jp/dbget-bin/www_bget?KO:K02194 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 MINT MINT-1250139 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1250139 OMA GPAIVWI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GPAIVWI PANTHER PTHR30070:SF1 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30070:SF1 PRINTS PR01414 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01414 PSORT swissprot:CCMB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CCMB_ECOLI PSORT-B swissprot:CCMB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CCMB_ECOLI PSORT2 swissprot:CCMB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CCMB_ECOLI Pfam PF03379 http://pfam.xfam.org/family/PF03379 Phobius swissprot:CCMB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CCMB_ECOLI PhylomeDB P0ABL8 http://phylomedb.org/?seqid=P0ABL8 ProteinModelPortal P0ABL8 http://www.proteinmodelportal.org/query/uniprot/P0ABL8 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7635817 http://www.ncbi.nlm.nih.gov/pubmed/7635817 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416704 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416704 STRING 511145.b2200 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2200&targetmode=cogs STRING COG2386 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2386&targetmode=cogs TIGRFAMs TIGR01190 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01190 UniProtKB CCMB_ECOLI http://www.uniprot.org/uniprot/CCMB_ECOLI UniProtKB-AC P0ABL8 http://www.uniprot.org/uniprot/P0ABL8 charge swissprot:CCMB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CCMB_ECOLI eggNOG COG2386 http://eggnogapi.embl.de/nog_data/html/tree/COG2386 eggNOG ENOG4105CA5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CA5 epestfind swissprot:CCMB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CCMB_ECOLI garnier swissprot:CCMB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CCMB_ECOLI helixturnhelix swissprot:CCMB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CCMB_ECOLI hmoment swissprot:CCMB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CCMB_ECOLI iep swissprot:CCMB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CCMB_ECOLI inforesidue swissprot:CCMB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CCMB_ECOLI octanol swissprot:CCMB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CCMB_ECOLI pepcoil swissprot:CCMB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CCMB_ECOLI pepdigest swissprot:CCMB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CCMB_ECOLI pepinfo swissprot:CCMB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CCMB_ECOLI pepnet swissprot:CCMB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CCMB_ECOLI pepstats swissprot:CCMB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CCMB_ECOLI pepwheel swissprot:CCMB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CCMB_ECOLI pepwindow swissprot:CCMB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CCMB_ECOLI sigcleave swissprot:CCMB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CCMB_ECOLI ## Database ID URL or Descriptions # AltName PAAF_ECOLI Enoyl-CoA hydratase # BRENDA 4.2.1.17 2026 # BioGrid 4260970 248 # CATALYTIC ACTIVITY (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl- CoA + H(2)O. {ECO:0000269|PubMed 20660314}. # DISRUPTION PHENOTYPE Mutants accumulate delta3-dehydroadipate and are unable to use phenylacetate as a carbon source. {ECO:0000269|PubMed 12846838}. # EcoGene EG13740 paaF # FUNCTION PAAF_ECOLI Catalyzes the reversible conversion of enzymatically produced 2,3-dehydroadipyl-CoA into 3-hydroxyadipyl-CoA. {ECO 0000269|PubMed 20660314, ECO 0000269|PubMed 9748275}. # GO_function GO:0004300 enoyl-CoA hydratase activity; IDA:UniProtKB. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0006635 fatty acid beta-oxidation; IBA:GO_Central. # GO_process GO:0010124 phenylacetate catabolic process; IMP:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.90.226.10 -; 1. # INDUCTION PAAF_ECOLI Activated by cAMP receptor protein (CRP), integration host factor (IHF) and by phenylacetyl-coenzyme A (PA-CoA) that prevents PaaX from binding its target sequences. Inhibited by PaaX. {ECO 0000269|PubMed 10766858, ECO 0000269|PubMed 9748275}. # InterPro IPR001753 Crotonase_core_superfam # InterPro IPR018376 Enoyl-CoA_hyd/isom_CS # InterPro IPR029045 ClpP/crotonase-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00071 Fatty acid metabolism # KEGG_Pathway ko00280 Valine, leucine and isoleucine degradation # KEGG_Pathway ko00281 Geraniol degradation # KEGG_Pathway ko00310 Lysine degradation # KEGG_Pathway ko00360 Phenylalanine metabolism # KEGG_Pathway ko00362 Benzoate degradation # KEGG_Pathway ko00380 Tryptophan metabolism # KEGG_Pathway ko00410 beta-Alanine metabolism # KEGG_Pathway ko00627 Aminobenzoate degradation # KEGG_Pathway ko00640 Propanoate metabolism # KEGG_Pathway ko00650 Butanoate metabolism # KEGG_Pathway ko00903 Limonene and pinene degradation # KEGG_Pathway ko00930 Caprolactam degradation # Organism PAAF_ECOLI Escherichia coli (strain K12) # PATHWAY PAAF_ECOLI Aromatic compound metabolism; phenylacetate degradation. # PATRIC 32118072 VBIEscCol129921_1456 # PDB 4FZW X-ray; 2.55 A; A/B=1-255 # PIR D64890 D64890 # PROSITE PS00166 ENOYL_COA_HYDRATASE # Pfam PF00378 ECH_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PAAF_ECOLI 2,3-dehydroadipyl-CoA hydratase # RefSeq NP_415911 NC_000913.3 # RefSeq WP_001292353 NZ_LN832404.1 # SIMILARITY Belongs to the enoyl-CoA hydratase/isomerase family. {ECO 0000305}. # SUPFAM SSF52096 SSF52096 # eggNOG COG1024 LUCA # eggNOG ENOG4105E39 Bacteria BLAST swissprot:PAAF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PAAF_ECOLI BioCyc ECOL316407:JW1388-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1388-MONOMER BioCyc EcoCyc:G6714-MONOMER http://biocyc.org/getid?id=EcoCyc:G6714-MONOMER COG COG1024 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1024 DIP DIP-10425N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10425N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1432-1033.2003.03683.x http://dx.doi.org/10.1046/j.1432-1033.2003.03683.x DOI 10.1073/pnas.1005399107 http://dx.doi.org/10.1073/pnas.1005399107 DOI 10.1074/jbc.273.40.25974 http://dx.doi.org/10.1074/jbc.273.40.25974 DOI 10.1074/jbc.275.16.12214 http://dx.doi.org/10.1074/jbc.275.16.12214 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.1.17 http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.17 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X97452 http://www.ebi.ac.uk/ena/data/view/X97452 ENZYME 4.2.1.17 http://enzyme.expasy.org/EC/4.2.1.17 EchoBASE EB3503 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3503 EcoGene EG13740 http://www.ecogene.org/geneInfo.php?eg_id=EG13740 EnsemblBacteria AAC74475 http://www.ensemblgenomes.org/id/AAC74475 EnsemblBacteria AAC74475 http://www.ensemblgenomes.org/id/AAC74475 EnsemblBacteria BAA14999 http://www.ensemblgenomes.org/id/BAA14999 EnsemblBacteria BAA14999 http://www.ensemblgenomes.org/id/BAA14999 EnsemblBacteria BAA14999 http://www.ensemblgenomes.org/id/BAA14999 EnsemblBacteria b1393 http://www.ensemblgenomes.org/id/b1393 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004300 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004300 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0006635 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006635 GO_process GO:0010124 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010124 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.90.226.10 http://www.cathdb.info/version/latest/superfamily/3.90.226.10 GeneID 946011 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946011 HOGENOM HOG000027939 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000027939&db=HOGENOM6 InParanoid P76082 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76082 IntAct P76082 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76082* IntEnz 4.2.1.17 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.17 InterPro IPR001753 http://www.ebi.ac.uk/interpro/entry/IPR001753 InterPro IPR018376 http://www.ebi.ac.uk/interpro/entry/IPR018376 InterPro IPR029045 http://www.ebi.ac.uk/interpro/entry/IPR029045 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1388 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1388 KEGG_Gene eco:b1393 http://www.genome.jp/dbget-bin/www_bget?eco:b1393 KEGG_Orthology KO:K01692 http://www.genome.jp/dbget-bin/www_bget?KO:K01692 KEGG_Pathway ko00071 http://www.genome.jp/kegg-bin/show_pathway?ko00071 KEGG_Pathway ko00280 http://www.genome.jp/kegg-bin/show_pathway?ko00280 KEGG_Pathway ko00281 http://www.genome.jp/kegg-bin/show_pathway?ko00281 KEGG_Pathway ko00310 http://www.genome.jp/kegg-bin/show_pathway?ko00310 KEGG_Pathway ko00360 http://www.genome.jp/kegg-bin/show_pathway?ko00360 KEGG_Pathway ko00362 http://www.genome.jp/kegg-bin/show_pathway?ko00362 KEGG_Pathway ko00380 http://www.genome.jp/kegg-bin/show_pathway?ko00380 KEGG_Pathway ko00410 http://www.genome.jp/kegg-bin/show_pathway?ko00410 KEGG_Pathway ko00627 http://www.genome.jp/kegg-bin/show_pathway?ko00627 KEGG_Pathway ko00640 http://www.genome.jp/kegg-bin/show_pathway?ko00640 KEGG_Pathway ko00650 http://www.genome.jp/kegg-bin/show_pathway?ko00650 KEGG_Pathway ko00903 http://www.genome.jp/kegg-bin/show_pathway?ko00903 KEGG_Pathway ko00930 http://www.genome.jp/kegg-bin/show_pathway?ko00930 KEGG_Reaction rn:R03026 http://www.genome.jp/dbget-bin/www_bget?rn:R03026 KEGG_Reaction rn:R03045 http://www.genome.jp/dbget-bin/www_bget?rn:R03045 KEGG_Reaction rn:R04137 http://www.genome.jp/dbget-bin/www_bget?rn:R04137 KEGG_Reaction rn:R04170 http://www.genome.jp/dbget-bin/www_bget?rn:R04170 KEGG_Reaction rn:R04204 http://www.genome.jp/dbget-bin/www_bget?rn:R04204 KEGG_Reaction rn:R04224 http://www.genome.jp/dbget-bin/www_bget?rn:R04224 KEGG_Reaction rn:R04738 http://www.genome.jp/dbget-bin/www_bget?rn:R04738 KEGG_Reaction rn:R04740 http://www.genome.jp/dbget-bin/www_bget?rn:R04740 KEGG_Reaction rn:R04744 http://www.genome.jp/dbget-bin/www_bget?rn:R04744 KEGG_Reaction rn:R04746 http://www.genome.jp/dbget-bin/www_bget?rn:R04746 KEGG_Reaction rn:R04749 http://www.genome.jp/dbget-bin/www_bget?rn:R04749 KEGG_Reaction rn:R05595 http://www.genome.jp/dbget-bin/www_bget?rn:R05595 KEGG_Reaction rn:R06411 http://www.genome.jp/dbget-bin/www_bget?rn:R06411 KEGG_Reaction rn:R06412 http://www.genome.jp/dbget-bin/www_bget?rn:R06412 KEGG_Reaction rn:R06942 http://www.genome.jp/dbget-bin/www_bget?rn:R06942 KEGG_Reaction rn:R08093 http://www.genome.jp/dbget-bin/www_bget?rn:R08093 OMA DLLIHRH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DLLIHRH PDB 4FZW http://www.ebi.ac.uk/pdbe-srv/view/entry/4FZW PDBsum 4FZW http://www.ebi.ac.uk/pdbsum/4FZW PROSITE PS00166 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00166 PSORT swissprot:PAAF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PAAF_ECOLI PSORT-B swissprot:PAAF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PAAF_ECOLI PSORT2 swissprot:PAAF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PAAF_ECOLI Pfam PF00378 http://pfam.xfam.org/family/PF00378 Phobius swissprot:PAAF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PAAF_ECOLI PhylomeDB P76082 http://phylomedb.org/?seqid=P76082 ProteinModelPortal P76082 http://www.proteinmodelportal.org/query/uniprot/P76082 PubMed 10766858 http://www.ncbi.nlm.nih.gov/pubmed/10766858 PubMed 12846838 http://www.ncbi.nlm.nih.gov/pubmed/12846838 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20660314 http://www.ncbi.nlm.nih.gov/pubmed/20660314 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9748275 http://www.ncbi.nlm.nih.gov/pubmed/9748275 RefSeq NP_415911 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415911 RefSeq WP_001292353 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001292353 SMR P76082 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76082 STRING 511145.b1393 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1393&targetmode=cogs STRING COG1024 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1024&targetmode=cogs SUPFAM SSF52096 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52096 UniProtKB PAAF_ECOLI http://www.uniprot.org/uniprot/PAAF_ECOLI UniProtKB-AC P76082 http://www.uniprot.org/uniprot/P76082 charge swissprot:PAAF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PAAF_ECOLI eggNOG COG1024 http://eggnogapi.embl.de/nog_data/html/tree/COG1024 eggNOG ENOG4105E39 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E39 epestfind swissprot:PAAF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PAAF_ECOLI garnier swissprot:PAAF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PAAF_ECOLI helixturnhelix swissprot:PAAF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PAAF_ECOLI hmoment swissprot:PAAF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PAAF_ECOLI iep swissprot:PAAF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PAAF_ECOLI inforesidue swissprot:PAAF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PAAF_ECOLI octanol swissprot:PAAF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PAAF_ECOLI pepcoil swissprot:PAAF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PAAF_ECOLI pepdigest swissprot:PAAF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PAAF_ECOLI pepinfo swissprot:PAAF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PAAF_ECOLI pepnet swissprot:PAAF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PAAF_ECOLI pepstats swissprot:PAAF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PAAF_ECOLI pepwheel swissprot:PAAF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PAAF_ECOLI pepwindow swissprot:PAAF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PAAF_ECOLI sigcleave swissprot:PAAF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PAAF_ECOLI ## Database ID URL or Descriptions # AltName CHBR_ECOLI Chb operon repressor # BioGrid 4259133 10 # EcoGene EG10143 chbR # FUNCTION CHBR_ECOLI Dual-function repressor/activator of the chbBCARFG operon. In the absence of the inducing sugar chitobiose, together with NagC, represses the chbBCARFG operon for the uptake and metabolism of chitobiose. In association with Crp, and probably in the presence of chitobiose 6-phosphate, induces the transcription of the chbBCARFG operon. {ECO 0000269|PubMed 18028317}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0000987 core promoter proximal region sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0001046 core promoter sequence-specific DNA binding; IDA:EcoCyc. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IBA:GO_Central. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.60 -; 1. # Gene3D 2.60.120.10 -; 1. # INDUCTION CHBR_ECOLI By N,N'-diacetylchitobiose. # IntAct P17410 7 # InterPro IPR009057 Homeodomain-like # InterPro IPR011051 RmlC_Cupin # InterPro IPR013096 Cupin_2 # InterPro IPR014710 RmlC-like_jellyroll # InterPro IPR018060 HTH_AraC # InterPro IPR018062 HTH_AraC-typ_CS # InterPro IPR020449 Tscrpt_reg_HTH_AraC-type # KEGG_Brite ko03000 Transcription factors # MISCELLANEOUS CHBR_ECOLI Under prolonged growth on cellobiose as the sole carbon source, spontaneous mutations in chbR and nagC alter the regulation of the chbBCARFG operon, allowing the uptake and metabolism of cellobiose. The mutated regulator makes stronger contact with the target DNA sequence within the chb promoter and has enhanced recognition of cellobiose 6-phosphate as an inducer. # Organism CHBR_ECOLI Escherichia coli (strain K12) # PATRIC 32118779 VBIEscCol129921_1807 # PIR S10873 S10873 # PRINTS PR00032 HTHARAC # PROSITE PS00041 HTH_ARAC_FAMILY_1 # PROSITE PS01124 HTH_ARAC_FAMILY_2 # Pfam PF07883 Cupin_2 # Pfam PF12833 HTH_18 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CHBR_ECOLI HTH-type transcriptional regulator ChbR # RefSeq NP_416249 NC_000913.3 # SIMILARITY Contains 1 HTH araC/xylS-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00593}. # SMART SM00342 HTH_ARAC # SUBUNIT Homodimer. {ECO:0000305|PubMed 15066032}. # SUPFAM SSF46689 SSF46689 # SUPFAM SSF51182 SSF51182 # eggNOG ENOG4105EZV Bacteria # eggNOG ENOG410XRRP LUCA BLAST swissprot:CHBR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CHBR_ECOLI BioCyc ECOL316407:JW1724-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1724-MONOMER BioCyc EcoCyc:EG10143-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10143-MONOMER COG COG2207 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2207 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.94.26.14367 http://dx.doi.org/10.1073/pnas.94.26.14367 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1111/j.1365-2958.2004.03986.x http://dx.doi.org/10.1111/j.1365-2958.2004.03986.x DOI 10.1111/j.1365-2958.2007.05999.x http://dx.doi.org/10.1111/j.1365-2958.2007.05999.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X52890 http://www.ebi.ac.uk/ena/data/view/X52890 EchoBASE EB0141 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0141 EcoGene EG10143 http://www.ecogene.org/geneInfo.php?eg_id=EG10143 EnsemblBacteria AAC74805 http://www.ensemblgenomes.org/id/AAC74805 EnsemblBacteria AAC74805 http://www.ensemblgenomes.org/id/AAC74805 EnsemblBacteria BAA15516 http://www.ensemblgenomes.org/id/BAA15516 EnsemblBacteria BAA15516 http://www.ensemblgenomes.org/id/BAA15516 EnsemblBacteria BAA15516 http://www.ensemblgenomes.org/id/BAA15516 EnsemblBacteria b1735 http://www.ensemblgenomes.org/id/b1735 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000987 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000987 GO_function GO:0001046 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001046 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 Gene3D 2.60.120.10 http://www.cathdb.info/version/latest/superfamily/2.60.120.10 GeneID 946247 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946247 HOGENOM HOG000121054 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000121054&db=HOGENOM6 InParanoid P17410 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P17410 IntAct P17410 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P17410* InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR011051 http://www.ebi.ac.uk/interpro/entry/IPR011051 InterPro IPR013096 http://www.ebi.ac.uk/interpro/entry/IPR013096 InterPro IPR014710 http://www.ebi.ac.uk/interpro/entry/IPR014710 InterPro IPR018060 http://www.ebi.ac.uk/interpro/entry/IPR018060 InterPro IPR018062 http://www.ebi.ac.uk/interpro/entry/IPR018062 InterPro IPR020449 http://www.ebi.ac.uk/interpro/entry/IPR020449 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW1724 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1724 KEGG_Gene eco:b1735 http://www.genome.jp/dbget-bin/www_bget?eco:b1735 KEGG_Orthology KO:K03490 http://www.genome.jp/dbget-bin/www_bget?KO:K03490 OMA NRLRHHR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NRLRHHR PRINTS PR00032 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00032 PROSITE PS00041 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00041 PROSITE PS01124 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01124 PSORT swissprot:CHBR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CHBR_ECOLI PSORT-B swissprot:CHBR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CHBR_ECOLI PSORT2 swissprot:CHBR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CHBR_ECOLI Pfam PF07883 http://pfam.xfam.org/family/PF07883 Pfam PF12833 http://pfam.xfam.org/family/PF12833 Phobius swissprot:CHBR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CHBR_ECOLI PhylomeDB P17410 http://phylomedb.org/?seqid=P17410 ProteinModelPortal P17410 http://www.proteinmodelportal.org/query/uniprot/P17410 PubMed 15066032 http://www.ncbi.nlm.nih.gov/pubmed/15066032 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18028317 http://www.ncbi.nlm.nih.gov/pubmed/18028317 PubMed 2179047 http://www.ncbi.nlm.nih.gov/pubmed/2179047 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9405618 http://www.ncbi.nlm.nih.gov/pubmed/9405618 RefSeq NP_416249 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416249 SMART SM00342 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00342 SMR P17410 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P17410 STRING 511145.b1735 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1735&targetmode=cogs STRING COG2207 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2207&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF51182 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51182 UniProtKB CHBR_ECOLI http://www.uniprot.org/uniprot/CHBR_ECOLI UniProtKB-AC P17410 http://www.uniprot.org/uniprot/P17410 charge swissprot:CHBR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CHBR_ECOLI eggNOG ENOG4105EZV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EZV eggNOG ENOG410XRRP http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRRP epestfind swissprot:CHBR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CHBR_ECOLI garnier swissprot:CHBR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CHBR_ECOLI helixturnhelix swissprot:CHBR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CHBR_ECOLI hmoment swissprot:CHBR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CHBR_ECOLI iep swissprot:CHBR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CHBR_ECOLI inforesidue swissprot:CHBR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CHBR_ECOLI octanol swissprot:CHBR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CHBR_ECOLI pepcoil swissprot:CHBR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CHBR_ECOLI pepdigest swissprot:CHBR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CHBR_ECOLI pepinfo swissprot:CHBR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CHBR_ECOLI pepnet swissprot:CHBR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CHBR_ECOLI pepstats swissprot:CHBR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CHBR_ECOLI pepwheel swissprot:CHBR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CHBR_ECOLI pepwindow swissprot:CHBR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CHBR_ECOLI sigcleave swissprot:CHBR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CHBR_ECOLI ## Database ID URL or Descriptions # BioGrid 4260323 16 # EcoGene EG13497 yeaK # GO_function GO:0002161 aminoacyl-tRNA editing activity; IDA:EcoCyc. # GO_function GO:0002196 Ser-tRNA(Ala) hydrolase activity; IDA:EcoCyc. # GO_process GO:0045903 positive regulation of translational fidelity; IMP:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0008150 biological_process # Gene3D 3.90.960.10 -; 1. # IntAct P64483 12 # InterPro IPR007214 YbaK/aa-tRNA-synth-assoc-dom # Organism YEAK_ECOLI Escherichia coli (strain K12) # PATRIC 32118885 VBIEscCol129921_1860 # PIR C64939 C64939 # Pfam PF04073 tRNA_edit # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEAK_ECOLI Uncharacterized protein YeaK # RefSeq NP_416301 NC_000913.3 # RefSeq WP_000138043 NZ_LN832404.1 # SUPFAM SSF55826 SSF55826 # eggNOG COG2606 LUCA # eggNOG ENOG4108KXH Bacteria BLAST swissprot:YEAK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEAK_ECOLI BioCyc ECOL316407:JW1776-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1776-MONOMER BioCyc EcoCyc:G6973-MONOMER http://biocyc.org/getid?id=EcoCyc:G6973-MONOMER DIP DIP-48168N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48168N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3270 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3270 EcoGene EG13497 http://www.ecogene.org/geneInfo.php?eg_id=EG13497 EnsemblBacteria AAC74857 http://www.ensemblgenomes.org/id/AAC74857 EnsemblBacteria AAC74857 http://www.ensemblgenomes.org/id/AAC74857 EnsemblBacteria BAE76526 http://www.ensemblgenomes.org/id/BAE76526 EnsemblBacteria BAE76526 http://www.ensemblgenomes.org/id/BAE76526 EnsemblBacteria BAE76526 http://www.ensemblgenomes.org/id/BAE76526 EnsemblBacteria b1787 http://www.ensemblgenomes.org/id/b1787 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0002161 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002161 GO_function GO:0002196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002196 GO_process GO:0045903 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045903 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.90.960.10 http://www.cathdb.info/version/latest/superfamily/3.90.960.10 GeneID 946303 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946303 HOGENOM HOG000191922 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000191922&db=HOGENOM6 InParanoid P64483 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P64483 IntAct P64483 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P64483* InterPro IPR007214 http://www.ebi.ac.uk/interpro/entry/IPR007214 KEGG_Gene ecj:JW1776 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1776 KEGG_Gene eco:b1787 http://www.genome.jp/dbget-bin/www_bget?eco:b1787 OMA AKAMLCT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AKAMLCT PSORT swissprot:YEAK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEAK_ECOLI PSORT-B swissprot:YEAK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEAK_ECOLI PSORT2 swissprot:YEAK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEAK_ECOLI Pfam PF04073 http://pfam.xfam.org/family/PF04073 Phobius swissprot:YEAK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEAK_ECOLI PhylomeDB P64483 http://phylomedb.org/?seqid=P64483 ProteinModelPortal P64483 http://www.proteinmodelportal.org/query/uniprot/P64483 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416301 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416301 RefSeq WP_000138043 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000138043 SMR P64483 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P64483 STRING 511145.b1787 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1787&targetmode=cogs SUPFAM SSF55826 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55826 UniProtKB YEAK_ECOLI http://www.uniprot.org/uniprot/YEAK_ECOLI UniProtKB-AC P64483 http://www.uniprot.org/uniprot/P64483 charge swissprot:YEAK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEAK_ECOLI eggNOG COG2606 http://eggnogapi.embl.de/nog_data/html/tree/COG2606 eggNOG ENOG4108KXH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108KXH epestfind swissprot:YEAK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEAK_ECOLI garnier swissprot:YEAK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEAK_ECOLI helixturnhelix swissprot:YEAK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEAK_ECOLI hmoment swissprot:YEAK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEAK_ECOLI iep swissprot:YEAK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEAK_ECOLI inforesidue swissprot:YEAK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEAK_ECOLI octanol swissprot:YEAK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEAK_ECOLI pepcoil swissprot:YEAK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEAK_ECOLI pepdigest swissprot:YEAK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEAK_ECOLI pepinfo swissprot:YEAK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEAK_ECOLI pepnet swissprot:YEAK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEAK_ECOLI pepstats swissprot:YEAK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEAK_ECOLI pepwheel swissprot:YEAK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEAK_ECOLI pepwindow swissprot:YEAK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEAK_ECOLI sigcleave swissprot:YEAK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEAK_ECOLI ## Database ID URL or Descriptions # BioGrid 4261357 335 # CAZy GT4 Glycosyltransferase Family 4 # EcoGene EG11985 wbbK # FUNCTION WBBK_ECOLI May be a glycosyltransferase involved in the transfer of UDP-GalF and UDP-glucose. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_function GO:0016740 transferase activity; IEA:UniProtKB-KW. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # IntAct P37751 5 # InterPro IPR001296 Glyco_trans_1 # Organism WBBK_ECOLI Escherichia coli (strain K12) # PATHWAY WBBK_ECOLI Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. # PATRIC 32119399 VBIEscCol129921_2109 # PIR I69647 I69647 # Pfam PF00534 Glycos_transf_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName WBBK_ECOLI Putative glycosyltransferase WbbK # RefSeq NP_416536 NC_000913.3 # RefSeq WP_000520320 NZ_LN832404.1 # SUBCELLULAR LOCATION WBBK_ECOLI Cell inner membrane {ECO 0000305}; Peripheral membrane protein {ECO 0000305}. # eggNOG COG0438 LUCA # eggNOG ENOG4108TMJ Bacteria BLAST swissprot:WBBK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:WBBK_ECOLI BioCyc ECOL316407:JW2017-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2017-MONOMER BioCyc EcoCyc:EG11985-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11985-MONOMER DIP DIP-11874N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11874N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1099/13500872-140-1-49 http://dx.doi.org/10.1099/13500872-140-1-49 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19537 http://www.ebi.ac.uk/ena/data/view/L19537 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U03041 http://www.ebi.ac.uk/ena/data/view/U03041 EMBL U09876 http://www.ebi.ac.uk/ena/data/view/U09876 EchoBASE EB1928 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1928 EcoGene EG11985 http://www.ecogene.org/geneInfo.php?eg_id=EG11985 EnsemblBacteria AAC75093 http://www.ensemblgenomes.org/id/AAC75093 EnsemblBacteria AAC75093 http://www.ensemblgenomes.org/id/AAC75093 EnsemblBacteria BAA15874 http://www.ensemblgenomes.org/id/BAA15874 EnsemblBacteria BAA15874 http://www.ensemblgenomes.org/id/BAA15874 EnsemblBacteria BAA15874 http://www.ensemblgenomes.org/id/BAA15874 EnsemblBacteria b2032 http://www.ensemblgenomes.org/id/b2032 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0016740 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016740 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 946555 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946555 HOGENOM HOG000054841 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000054841&db=HOGENOM6 InParanoid P37751 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37751 IntAct P37751 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37751* InterPro IPR001296 http://www.ebi.ac.uk/interpro/entry/IPR001296 KEGG_Gene ecj:JW2017 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2017 KEGG_Gene eco:b2032 http://www.genome.jp/dbget-bin/www_bget?eco:b2032 OMA DLPYAHE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DLPYAHE PSORT swissprot:WBBK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:WBBK_ECOLI PSORT-B swissprot:WBBK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:WBBK_ECOLI PSORT2 swissprot:WBBK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:WBBK_ECOLI Pfam PF00534 http://pfam.xfam.org/family/PF00534 Phobius swissprot:WBBK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:WBBK_ECOLI PhylomeDB P37751 http://phylomedb.org/?seqid=P37751 ProteinModelPortal P37751 http://www.proteinmodelportal.org/query/uniprot/P37751 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7512872 http://www.ncbi.nlm.nih.gov/pubmed/7512872 PubMed 7517390 http://www.ncbi.nlm.nih.gov/pubmed/7517390 PubMed 7517391 http://www.ncbi.nlm.nih.gov/pubmed/7517391 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416536 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416536 RefSeq WP_000520320 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000520320 STRING 511145.b2032 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2032&targetmode=cogs UniProtKB WBBK_ECOLI http://www.uniprot.org/uniprot/WBBK_ECOLI UniProtKB-AC P37751 http://www.uniprot.org/uniprot/P37751 charge swissprot:WBBK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:WBBK_ECOLI eggNOG COG0438 http://eggnogapi.embl.de/nog_data/html/tree/COG0438 eggNOG ENOG4108TMJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108TMJ epestfind swissprot:WBBK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:WBBK_ECOLI garnier swissprot:WBBK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:WBBK_ECOLI helixturnhelix swissprot:WBBK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:WBBK_ECOLI hmoment swissprot:WBBK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:WBBK_ECOLI iep swissprot:WBBK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:WBBK_ECOLI inforesidue swissprot:WBBK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:WBBK_ECOLI octanol swissprot:WBBK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:WBBK_ECOLI pepcoil swissprot:WBBK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:WBBK_ECOLI pepdigest swissprot:WBBK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:WBBK_ECOLI pepinfo swissprot:WBBK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:WBBK_ECOLI pepnet swissprot:WBBK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:WBBK_ECOLI pepstats swissprot:WBBK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:WBBK_ECOLI pepwheel swissprot:WBBK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:WBBK_ECOLI pepwindow swissprot:WBBK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:WBBK_ECOLI sigcleave swissprot:WBBK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:WBBK_ECOLI ## Database ID URL or Descriptions # BioGrid 4259147 8 # EcoGene EG14382 yobF # GO_process GO:0034605 cellular response to heat; IEP:EcoCyc. # GO_process GO:0036460 cellular response to cell envelope stress; IMP:EcoCyc. # GO_process GO:0097533 cellular stress response to acid chemical; IMP:EcoCyc. # GOslim_process GO:0006950 response to stress # INDUCTION YOBF_ECOLI Expressed during stationary phase, induced at 45 degrees Celsius (at protein level), at a post-transcriptional level. {ECO 0000269|PubMed 19121005, ECO 0000269|PubMed 19734316}. # InterPro IPR019672 DUF2527 # Organism YOBF_ECOLI Escherichia coli (strain K12) # PATRIC 32118967 VBIEscCol129921_1901 # PIR H64943 H64943 # Pfam PF10736 DUF2527 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YOBF_ECOLI Uncharacterized protein YobF # RefSeq NP_416338 NC_000913.3 # RefSeq WP_001295496 NZ_LN832404.1 BLAST swissprot:YOBF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YOBF_ECOLI BioCyc ECOL316407:JW1813-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1813-MONOMER BioCyc EcoCyc:G7000-MONOMER http://biocyc.org/getid?id=EcoCyc:G7000-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2008.06495.x http://dx.doi.org/10.1111/j.1365-2958.2008.06495.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00872-09 http://dx.doi.org/10.1128/JB.00872-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4125 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4125 EcoGene EG14382 http://www.ecogene.org/geneInfo.php?eg_id=EG14382 EnsemblBacteria AAC74894 http://www.ensemblgenomes.org/id/AAC74894 EnsemblBacteria AAC74894 http://www.ensemblgenomes.org/id/AAC74894 EnsemblBacteria BAE76537 http://www.ensemblgenomes.org/id/BAE76537 EnsemblBacteria BAE76537 http://www.ensemblgenomes.org/id/BAE76537 EnsemblBacteria BAE76537 http://www.ensemblgenomes.org/id/BAE76537 EnsemblBacteria b1824 http://www.ensemblgenomes.org/id/b1824 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0034605 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034605 GO_process GO:0036460 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036460 GO_process GO:0097533 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097533 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 946338 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946338 HOGENOM HOG000009489 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009489&db=HOGENOM6 InterPro IPR019672 http://www.ebi.ac.uk/interpro/entry/IPR019672 KEGG_Gene ecj:JW1813 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1813 KEGG_Gene eco:b1824 http://www.genome.jp/dbget-bin/www_bget?eco:b1824 PSORT swissprot:YOBF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YOBF_ECOLI PSORT-B swissprot:YOBF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YOBF_ECOLI PSORT2 swissprot:YOBF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YOBF_ECOLI Pfam PF10736 http://pfam.xfam.org/family/PF10736 Phobius swissprot:YOBF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YOBF_ECOLI ProteinModelPortal P64508 http://www.proteinmodelportal.org/query/uniprot/P64508 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19121005 http://www.ncbi.nlm.nih.gov/pubmed/19121005 PubMed 19734316 http://www.ncbi.nlm.nih.gov/pubmed/19734316 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416338 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416338 RefSeq WP_001295496 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295496 STRING 511145.b1824 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1824&targetmode=cogs UniProtKB YOBF_ECOLI http://www.uniprot.org/uniprot/YOBF_ECOLI UniProtKB-AC P64508 http://www.uniprot.org/uniprot/P64508 charge swissprot:YOBF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YOBF_ECOLI epestfind swissprot:YOBF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YOBF_ECOLI garnier swissprot:YOBF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YOBF_ECOLI helixturnhelix swissprot:YOBF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YOBF_ECOLI hmoment swissprot:YOBF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YOBF_ECOLI iep swissprot:YOBF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YOBF_ECOLI inforesidue swissprot:YOBF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YOBF_ECOLI octanol swissprot:YOBF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YOBF_ECOLI pepcoil swissprot:YOBF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YOBF_ECOLI pepdigest swissprot:YOBF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YOBF_ECOLI pepinfo swissprot:YOBF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YOBF_ECOLI pepnet swissprot:YOBF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YOBF_ECOLI pepstats swissprot:YOBF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YOBF_ECOLI pepwheel swissprot:YOBF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YOBF_ECOLI pepwindow swissprot:YOBF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YOBF_ECOLI sigcleave swissprot:YOBF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YOBF_ECOLI ## Database ID URL or Descriptions # AltName DKSA_ECOLI DnaK suppressor protein # BioGrid 4259742 22 # DISRUPTION PHENOTYPE Deletion blocks induction of rpoS by ppGpp, but does not alter relA expression, ppGpp regulation or RNA control during the stringent response. {ECO:0000269|PubMed 12142416}. # EcoGene EG10230 dksA # FUNCTION DKSA_ECOLI Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression. Binding to RNAP disrupts interaction of RNAP with DNA, inhibits formation of initiation complexes, and amplifies effects of ppGpp and the initiating NTP on rRNA transcription. Inhibits transcript elongation, exonucleolytic RNA cleavage and pyrophosphorolysis, and increases intrinsic termination. Also involved, with RecN, in repair of DNA double-strand breaks. {ECO 0000255|HAMAP-Rule MF_00926, ECO 0000269|PubMed 15294156, ECO 0000269|PubMed 15294157, ECO 0000269|PubMed 15948952, ECO 0000269|PubMed 16885445, ECO 0000269|PubMed 22210857}. # GO_component GO:0005737 cytoplasm; IDA:UniProtKB. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IEA:UniProtKB-HAMAP. # GO_process GO:0010468 regulation of gene expression; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # HAMAP MF_00926 DksA # IntAct P0ABS1 11 # InterPro IPR000962 Znf_DskA_TraR # InterPro IPR012784 DksA_RNA_pol-bd # InterPro IPR020458 Znf_DskA_TraR_CS # InterPro IPR020460 Znf_C4-type_bac # KEGG_Brite ko03000 Transcription factors # KEGG_Brite ko03009 Ribosome biogenesis # KEGG_Brite ko03021 Transcription machinery # MISCELLANEOUS Dosage-dependent suppressor of a dnaK deletion mutation. It suppressed not only the temperature-sensitive growth but also the filamentous phenotype of the dnaK deletion strain, while the defect of lambda growth is not suppressed (PubMed:2180916). {ECO 0000305|PubMed:2180916}. # Organism DKSA_ECOLI Escherichia coli (strain K12) # PATRIC 32115397 VBIEscCol129921_0150 # PDB 1TJL X-ray; 2.00 A; A/B/C/D/E/F/G/H/I/J=1-151 # PIR S45214 S45214 # PRINTS PR00618 DKSAZNFINGER # PROSITE PS01102 ZF_DKSA_1 # PROSITE PS51128 ZF_DKSA_2 # Pfam PF01258 zf-dskA_traR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RNA polymerase-binding transcription factor DksA {ECO:0000255|HAMAP-Rule MF_00926} # RefSeq NP_414687 NC_000913.3 # RefSeq WP_001155227 NZ_LN832404.1 # SIMILARITY Belongs to the DksA family. {ECO:0000255|HAMAP- Rule MF_00926}. # SIMILARITY Contains 1 dksA C4-type zinc finger. {ECO:0000255|HAMAP-Rule MF_00926}. # SUBCELLULAR LOCATION DKSA_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00926, ECO 0000269|PubMed 16858726}. # SUBUNIT DKSA_ECOLI Interacts directly with the RNA polymerase. {ECO 0000255|HAMAP-Rule MF_00926, ECO 0000269|PubMed 15294156, ECO 0000269|PubMed 15294157}. # TIGRFAMs TIGR02420 dksA # eggNOG COG1734 LUCA BLAST swissprot:DKSA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DKSA_ECOLI BioCyc ECOL316407:JW0141-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0141-MONOMER BioCyc EcoCyc:EG10230-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10230-MONOMER COG COG1734 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1734 DIP DIP-31875N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31875N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1002/elps.200500912 http://dx.doi.org/10.1002/elps.200500912 DOI 10.1006/jmbi.1998.1726 http://dx.doi.org/10.1006/jmbi.1998.1726 DOI 10.1016/j.cell.2004.06.030 http://dx.doi.org/10.1016/j.cell.2004.06.030 DOI 10.1016/j.cell.2004.07.009 http://dx.doi.org/10.1016/j.cell.2004.07.009 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1093/nar/gkr1273 http://dx.doi.org/10.1093/nar/gkr1273 DOI 10.1111/j.1365-2958.2005.04677.x http://dx.doi.org/10.1111/j.1365-2958.2005.04677.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00276-06 http://dx.doi.org/10.1128/JB.00276-06 DOI 10.1128/JB.184.16.4455-4465.2002 http://dx.doi.org/10.1128/JB.184.16.4455-4465.2002 DisProt DP00414 http://www.disprot.org/protein.php?id=DP00414 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M34945 http://www.ebi.ac.uk/ena/data/view/M34945 EMBL M60726 http://www.ebi.ac.uk/ena/data/view/M60726 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0226 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0226 EcoGene EG10230 http://www.ecogene.org/geneInfo.php?eg_id=EG10230 EnsemblBacteria AAC73256 http://www.ensemblgenomes.org/id/AAC73256 EnsemblBacteria AAC73256 http://www.ensemblgenomes.org/id/AAC73256 EnsemblBacteria BAB96722 http://www.ensemblgenomes.org/id/BAB96722 EnsemblBacteria BAB96722 http://www.ensemblgenomes.org/id/BAB96722 EnsemblBacteria BAB96722 http://www.ensemblgenomes.org/id/BAB96722 EnsemblBacteria b0145 http://www.ensemblgenomes.org/id/b0145 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_process GO:0010468 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010468 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 5549448 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5549448 GeneID 944850 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944850 HAMAP MF_00926 http://hamap.expasy.org/unirule/MF_00926 HOGENOM HOG000178407 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000178407&db=HOGENOM6 InParanoid P0ABS1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABS1 IntAct P0ABS1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABS1* InterPro IPR000962 http://www.ebi.ac.uk/interpro/entry/IPR000962 InterPro IPR012784 http://www.ebi.ac.uk/interpro/entry/IPR012784 InterPro IPR020458 http://www.ebi.ac.uk/interpro/entry/IPR020458 InterPro IPR020460 http://www.ebi.ac.uk/interpro/entry/IPR020460 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Brite ko03021 http://www.genome.jp/dbget-bin/www_bget?ko03021 KEGG_Gene ecj:JW0141 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0141 KEGG_Gene eco:b0145 http://www.genome.jp/dbget-bin/www_bget?eco:b0145 KEGG_Orthology KO:K06204 http://www.genome.jp/dbget-bin/www_bget?KO:K06204 MINT MINT-8413451 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8413451 OMA AQERHEK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AQERHEK PDB 1TJL http://www.ebi.ac.uk/pdbe-srv/view/entry/1TJL PDBsum 1TJL http://www.ebi.ac.uk/pdbsum/1TJL PRINTS PR00618 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00618 PROSITE PS01102 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01102 PROSITE PS51128 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51128 PSORT swissprot:DKSA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DKSA_ECOLI PSORT-B swissprot:DKSA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DKSA_ECOLI PSORT2 swissprot:DKSA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DKSA_ECOLI Pfam PF01258 http://pfam.xfam.org/family/PF01258 Phobius swissprot:DKSA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DKSA_ECOLI PhylomeDB P0ABS1 http://phylomedb.org/?seqid=P0ABS1 ProteinModelPortal P0ABS1 http://www.proteinmodelportal.org/query/uniprot/P0ABS1 PubMed 12142416 http://www.ncbi.nlm.nih.gov/pubmed/12142416 PubMed 15294156 http://www.ncbi.nlm.nih.gov/pubmed/15294156 PubMed 15294157 http://www.ncbi.nlm.nih.gov/pubmed/15294157 PubMed 15948952 http://www.ncbi.nlm.nih.gov/pubmed/15948952 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16858726 http://www.ncbi.nlm.nih.gov/pubmed/16858726 PubMed 16885445 http://www.ncbi.nlm.nih.gov/pubmed/16885445 PubMed 2013578 http://www.ncbi.nlm.nih.gov/pubmed/2013578 PubMed 2180916 http://www.ncbi.nlm.nih.gov/pubmed/2180916 PubMed 22210857 http://www.ncbi.nlm.nih.gov/pubmed/22210857 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 RefSeq NP_414687 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414687 RefSeq WP_001155227 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001155227 SMR P0ABS1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABS1 STRING 511145.b0145 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0145&targetmode=cogs STRING COG1734 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1734&targetmode=cogs SWISS-2DPAGE P0ABS1 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0ABS1 TIGRFAMs TIGR02420 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02420 UniProtKB DKSA_ECOLI http://www.uniprot.org/uniprot/DKSA_ECOLI UniProtKB-AC P0ABS1 http://www.uniprot.org/uniprot/P0ABS1 charge swissprot:DKSA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DKSA_ECOLI eggNOG COG1734 http://eggnogapi.embl.de/nog_data/html/tree/COG1734 epestfind swissprot:DKSA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DKSA_ECOLI garnier swissprot:DKSA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DKSA_ECOLI helixturnhelix swissprot:DKSA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DKSA_ECOLI hmoment swissprot:DKSA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DKSA_ECOLI iep swissprot:DKSA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DKSA_ECOLI inforesidue swissprot:DKSA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DKSA_ECOLI octanol swissprot:DKSA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DKSA_ECOLI pepcoil swissprot:DKSA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DKSA_ECOLI pepdigest swissprot:DKSA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DKSA_ECOLI pepinfo swissprot:DKSA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DKSA_ECOLI pepnet swissprot:DKSA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DKSA_ECOLI pepstats swissprot:DKSA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DKSA_ECOLI pepwheel swissprot:DKSA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DKSA_ECOLI pepwindow swissprot:DKSA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DKSA_ECOLI sigcleave swissprot:DKSA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DKSA_ECOLI ## Database ID URL or Descriptions # AltName PHNI_ECOLI Ribose 1-methylphosphonate 5-triphosphate synthase nucleosidase subunit # BIOPHYSICOCHEMICAL PROPERTIES PHNI_ECOLI Kinetic parameters KM=64 uM for GTP (in the presence of PhnI alone) {ECO 0000269|PubMed 22089136}; KM=95 uM for ATP (in the presence of PhnI alone) {ECO 0000269|PubMed 22089136}; KM=80 uM for GTP (in the presence of PhnI, PhnG, PhnH and PhnL) {ECO 0000269|PubMed 22089136}; KM=56 uM for ATP (in the presence of PhnI, PhnG, PhnH and PhnL) {ECO 0000269|PubMed 22089136}; Note=kcat is 1.4 sec(-1) for ATP hydrolysis in the presence of PhnI alone, and 20 sec(-1) for RPnTP synthesis from ATP in the presence of PhnI, PhnG, PhnH and PhnL.; # BioGrid 4263381 10 # CATALYTIC ACTIVITY ATP + H(2)O = adenine + D-ribose 5- triphosphate. {ECO:0000269|PubMed 22089136}. # CATALYTIC ACTIVITY ATP + methylphosphonate = alpha-D-ribose 1- methylphosphonate 5-triphosphate + adenine. {ECO:0000269|PubMed 22089136}. # EcoGene EG10718 phnI # FUNCTION PHNI_ECOLI Together with PhnG, PhnH and PhnL is required for the transfer of the ribose triphosphate moiety from ATP to methyl phosphonate. PhnI alone has nucleosidase activity, catalyzing the hydrolysis of ATP or GTP forming alpha-D-ribose 5-triphosphate and adenine or guanine, respectively. {ECO 0000269|PubMed 22089136}. # GO_component GO:0061694 alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase complex; IDA:EcoCyc. # GO_function GO:0061693 alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity; IDA:EcoCyc. # GO_process GO:0019700 organic phosphonate catabolic process; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0009056 catabolic process # INTERACTION PHNI_ECOLI P16685 phnG; NbExp=6; IntAct=EBI-1127704, EBI-9126715; # IntAct P16687 4 # InterPro IPR008773 PhnI # MISCELLANEOUS PHNI_ECOLI The sequence shown is that of strain K12. # Organism PHNI_ECOLI Escherichia coli (strain K12) # PATRIC 32123757 VBIEscCol129921_4227 # PDB 4XB6 X-ray; 1.70 A; C/G=1-354 # PIR B65219 B65219 # PIRSF PIRSF007313 PhnI # Pfam PF05861 PhnI # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PHNI_ECOLI Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnI # RefSeq NP_418523 NC_000913.3 # RefSeq WP_001295388 NZ_LN832404.1 # SIMILARITY Belongs to the PhnI family. {ECO 0000305}. # SUBUNIT Forms a complex with PhnG, PhnH, PhnJ and PhnK with the suggested composition PhnG(4)H(2)I(2)J(2)K. {ECO:0000269|PubMed 21705661}. # eggNOG COG3626 LUCA # eggNOG ENOG4105EKV Bacteria BLAST swissprot:PHNI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PHNI_ECOLI BioCyc ECOL316407:JW4060-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4060-MONOMER BioCyc EcoCyc:EG10718-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10718-MONOMER BioCyc MetaCyc:EG10718-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10718-MONOMER COG COG3626 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3626 DIP DIP-10488N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10488N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature10622 http://dx.doi.org/10.1038/nature10622 DOI 10.1073/pnas.1104922108 http://dx.doi.org/10.1073/pnas.1104922108 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.8.37 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.8.37 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D90227 http://www.ebi.ac.uk/ena/data/view/D90227 EMBL J05260 http://www.ebi.ac.uk/ena/data/view/J05260 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 2.7.8.37 http://enzyme.expasy.org/EC/2.7.8.37 EchoBASE EB0712 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0712 EcoGene EG10718 http://www.ecogene.org/geneInfo.php?eg_id=EG10718 EnsemblBacteria AAC77060 http://www.ensemblgenomes.org/id/AAC77060 EnsemblBacteria AAC77060 http://www.ensemblgenomes.org/id/AAC77060 EnsemblBacteria BAE78102 http://www.ensemblgenomes.org/id/BAE78102 EnsemblBacteria BAE78102 http://www.ensemblgenomes.org/id/BAE78102 EnsemblBacteria BAE78102 http://www.ensemblgenomes.org/id/BAE78102 EnsemblBacteria b4099 http://www.ensemblgenomes.org/id/b4099 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0061694 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061694 GO_function GO:0061693 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061693 GO_process GO:0019700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019700 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GeneID 948605 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948605 HOGENOM HOG000127007 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000127007&db=HOGENOM6 InParanoid P16687 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P16687 IntAct P16687 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P16687* IntEnz 2.7.8.37 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.8.37 InterPro IPR008773 http://www.ebi.ac.uk/interpro/entry/IPR008773 KEGG_Gene ecj:JW4060 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4060 KEGG_Gene eco:b4099 http://www.genome.jp/dbget-bin/www_bget?eco:b4099 KEGG_Orthology KO:K06164 http://www.genome.jp/dbget-bin/www_bget?KO:K06164 OMA IKQARGD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IKQARGD PDB 4XB6 http://www.ebi.ac.uk/pdbe-srv/view/entry/4XB6 PDBsum 4XB6 http://www.ebi.ac.uk/pdbsum/4XB6 PSORT swissprot:PHNI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PHNI_ECOLI PSORT-B swissprot:PHNI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PHNI_ECOLI PSORT2 swissprot:PHNI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PHNI_ECOLI Pfam PF05861 http://pfam.xfam.org/family/PF05861 Phobius swissprot:PHNI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PHNI_ECOLI PhylomeDB P16687 http://phylomedb.org/?seqid=P16687 ProteinModelPortal P16687 http://www.proteinmodelportal.org/query/uniprot/P16687 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1840580 http://www.ncbi.nlm.nih.gov/pubmed/1840580 PubMed 2155230 http://www.ncbi.nlm.nih.gov/pubmed/2155230 PubMed 21705661 http://www.ncbi.nlm.nih.gov/pubmed/21705661 PubMed 22089136 http://www.ncbi.nlm.nih.gov/pubmed/22089136 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418523 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418523 RefSeq WP_001295388 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295388 SMR P16687 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P16687 STRING 511145.b4099 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4099&targetmode=cogs STRING COG3626 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3626&targetmode=cogs UniProtKB PHNI_ECOLI http://www.uniprot.org/uniprot/PHNI_ECOLI UniProtKB-AC P16687 http://www.uniprot.org/uniprot/P16687 charge swissprot:PHNI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PHNI_ECOLI eggNOG COG3626 http://eggnogapi.embl.de/nog_data/html/tree/COG3626 eggNOG ENOG4105EKV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EKV epestfind swissprot:PHNI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PHNI_ECOLI garnier swissprot:PHNI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PHNI_ECOLI helixturnhelix swissprot:PHNI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PHNI_ECOLI hmoment swissprot:PHNI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PHNI_ECOLI iep swissprot:PHNI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PHNI_ECOLI inforesidue swissprot:PHNI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PHNI_ECOLI octanol swissprot:PHNI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PHNI_ECOLI pepcoil swissprot:PHNI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PHNI_ECOLI pepdigest swissprot:PHNI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PHNI_ECOLI pepinfo swissprot:PHNI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PHNI_ECOLI pepnet swissprot:PHNI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PHNI_ECOLI pepstats swissprot:PHNI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PHNI_ECOLI pepwheel swissprot:PHNI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PHNI_ECOLI pepwindow swissprot:PHNI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PHNI_ECOLI sigcleave swissprot:PHNI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PHNI_ECOLI ## Database ID URL or Descriptions # AltName RUTD_ECOLI Aminohydrolase # BioGrid 4262210 24 # CATALYTIC ACTIVITY RUTD_ECOLI (Z)-3-aminoacrylate + H(2)O = malonate semialdehyde + NH(3). # DISRUPTION PHENOTYPE Cells lacking this gene form less than the normal amount of malonic semialdehyde because a portion of the 3- carbon intermediate is diverted out of the Rut pathway. {ECO:0000269|PubMed 20400551}. # ESTHER ecoli-rutD RutD # EcoGene EG13856 rutD # FUNCTION RUTD_ECOLI May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in vivo, but not in vitro in the pyrimidine nitrogen degradation. {ECO 0000269|PubMed 16540542}. # GO_function GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; IEA:InterPro. # GO_process GO:0006208 pyrimidine nucleobase catabolic process; IMP:EcoCyc. # GO_process GO:0006212 uracil catabolic process; IMP:UniProtKB. # GO_process GO:0019740 nitrogen utilization; IMP:UniProtKB. # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.1820 -; 1. # HAMAP MF_00832 RutD # INDUCTION RUTD_ECOLI Up-regulated by the nitrogen regulatory protein C (NtrC also called GlnG) and repressed by RutR. {ECO 0000269|PubMed 11121068, ECO 0000269|PubMed 17919280}. # InterPro IPR000073 AB_hydrolase_1 # InterPro IPR019913 Pyrimidine_utilisation_RutD # InterPro IPR029058 AB_hydrolase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00240 Pyrimidine metabolism # MISCELLANEOUS RUTD_ECOLI The Rut pathway degrades exogenous pyrimidines as the sole nitrogen source at room temperature but not at 37 degrees Celsius, a restriction that is apparently a consequence of an inadequate ability to remove toxic malonic semialdehyde at the higher temperature (RutE/YdfG function). # Organism RUTD_ECOLI Escherichia coli (strain K12) # PATRIC 32117247 VBIEscCol129921_1047 # PIR G64842 G64842 # PRINTS PR00111 ABHYDROLASE # Pfam PF00561 Abhydrolase_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RUTD_ECOLI Putative aminoacrylate hydrolase RutD # RefSeq NP_415529 NC_000913.3 # RefSeq WP_000777653 NZ_LN832404.1 # SIMILARITY Belongs to the AB hydrolase superfamily. Hydrolase RutD family. {ECO 0000305}. # SIMILARITY Contains 1 AB hydrolase-1 (Alpha/Beta hydrolase fold 1) domain. {ECO 0000255}. # SUPFAM SSF53474 SSF53474 # TIGRFAMs TIGR03611 RutD # eggNOG COG0596 LUCA # eggNOG ENOG41074FZ Bacteria BLAST swissprot:RUTD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RUTD_ECOLI BioCyc ECOL316407:JW0994-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0994-MONOMER BioCyc EcoCyc:G6520-MONOMER http://biocyc.org/getid?id=EcoCyc:G6520-MONOMER COG COG0596 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0596 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0600521103 http://dx.doi.org/10.1073/pnas.0600521103 DOI 10.1073/pnas.97.26.14674 http://dx.doi.org/10.1073/pnas.97.26.14674 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.2007.05954.x http://dx.doi.org/10.1111/j.1365-2958.2007.05954.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00201-10 http://dx.doi.org/10.1128/JB.00201-10 EC_number EC:3.5.1.- http://www.genome.jp/dbget-bin/www_bget?EC:3.5.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.5.1.- http://enzyme.expasy.org/EC/3.5.1.- EchoBASE EB3616 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3616 EcoGene EG13856 http://www.ecogene.org/geneInfo.php?eg_id=EG13856 EnsemblBacteria AAC74094 http://www.ensemblgenomes.org/id/AAC74094 EnsemblBacteria AAC74094 http://www.ensemblgenomes.org/id/AAC74094 EnsemblBacteria BAA35776 http://www.ensemblgenomes.org/id/BAA35776 EnsemblBacteria BAA35776 http://www.ensemblgenomes.org/id/BAA35776 EnsemblBacteria BAA35776 http://www.ensemblgenomes.org/id/BAA35776 EnsemblBacteria b1009 http://www.ensemblgenomes.org/id/b1009 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016811 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016811 GO_process GO:0006208 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006208 GO_process GO:0006212 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006212 GO_process GO:0019740 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019740 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.1820 http://www.cathdb.info/version/latest/superfamily/3.40.50.1820 GeneID 946586 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946586 HAMAP MF_00832 http://hamap.expasy.org/unirule/MF_00832 HOGENOM HOG000028072 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000028072&db=HOGENOM6 InParanoid P75895 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75895 IntEnz 3.5.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.1 InterPro IPR000073 http://www.ebi.ac.uk/interpro/entry/IPR000073 InterPro IPR019913 http://www.ebi.ac.uk/interpro/entry/IPR019913 InterPro IPR029058 http://www.ebi.ac.uk/interpro/entry/IPR029058 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0994 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0994 KEGG_Gene eco:b1009 http://www.genome.jp/dbget-bin/www_bget?eco:b1009 KEGG_Orthology KO:K09023 http://www.genome.jp/dbget-bin/www_bget?KO:K09023 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Reaction rn:R09983 http://www.genome.jp/dbget-bin/www_bget?rn:R09983 OMA HREAACK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HREAACK PRINTS PR00111 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00111 PSORT swissprot:RUTD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RUTD_ECOLI PSORT-B swissprot:RUTD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RUTD_ECOLI PSORT2 swissprot:RUTD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RUTD_ECOLI Pfam PF00561 http://pfam.xfam.org/family/PF00561 Phobius swissprot:RUTD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RUTD_ECOLI PhylomeDB P75895 http://phylomedb.org/?seqid=P75895 ProteinModelPortal P75895 http://www.proteinmodelportal.org/query/uniprot/P75895 PubMed 11121068 http://www.ncbi.nlm.nih.gov/pubmed/11121068 PubMed 16540542 http://www.ncbi.nlm.nih.gov/pubmed/16540542 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17919280 http://www.ncbi.nlm.nih.gov/pubmed/17919280 PubMed 20400551 http://www.ncbi.nlm.nih.gov/pubmed/20400551 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415529 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415529 RefSeq WP_000777653 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000777653 SMR P75895 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75895 STRING 511145.b1009 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1009&targetmode=cogs STRING COG0596 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0596&targetmode=cogs SUPFAM SSF53474 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53474 TIGRFAMs TIGR03611 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03611 UniProtKB RUTD_ECOLI http://www.uniprot.org/uniprot/RUTD_ECOLI UniProtKB-AC P75895 http://www.uniprot.org/uniprot/P75895 charge swissprot:RUTD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RUTD_ECOLI eggNOG COG0596 http://eggnogapi.embl.de/nog_data/html/tree/COG0596 eggNOG ENOG41074FZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG41074FZ epestfind swissprot:RUTD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RUTD_ECOLI garnier swissprot:RUTD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RUTD_ECOLI helixturnhelix swissprot:RUTD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RUTD_ECOLI hmoment swissprot:RUTD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RUTD_ECOLI iep swissprot:RUTD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RUTD_ECOLI inforesidue swissprot:RUTD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RUTD_ECOLI octanol swissprot:RUTD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RUTD_ECOLI pepcoil swissprot:RUTD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RUTD_ECOLI pepdigest swissprot:RUTD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RUTD_ECOLI pepinfo swissprot:RUTD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RUTD_ECOLI pepnet swissprot:RUTD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RUTD_ECOLI pepstats swissprot:RUTD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RUTD_ECOLI pepwheel swissprot:RUTD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RUTD_ECOLI pepwindow swissprot:RUTD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RUTD_ECOLI sigcleave swissprot:RUTD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RUTD_ECOLI ## Database ID URL or Descriptions # AltName GHRB_ECOLI 2-ketoaldonate reductase # AltName GHRB_ECOLI 2-ketogluconate reductase # BIOPHYSICOCHEMICAL PROPERTIES GHRB_ECOLI Kinetic parameters KM=0.7 mM for hydroxypyruvate (at pH 7.5) {ECO 0000269|PubMed 11237876, ECO 0000269|PubMed 9811658}; KM=1.5 mM for 2-oxo-D-gluconate (at pH 7.5) {ECO 0000269|PubMed 11237876, ECO 0000269|PubMed 9811658}; KM=6.6 mM for glyoxylate (at pH 7.5) {ECO 0000269|PubMed 11237876, ECO 0000269|PubMed 9811658}; Vmax=345 umol/min/mg enzyme with glyoxylate as substrate (at pH 7) {ECO 0000269|PubMed 11237876, ECO 0000269|PubMed 9811658}; Vmax=123 umol/min/mg enzyme with hydroxypyruvate as substrate (at pH 7) {ECO 0000269|PubMed 11237876, ECO 0000269|PubMed 9811658}; Vmax=69 umol/min/mg enzyme with 2-oxo-D-gluconate as substrate (at pH 7) {ECO 0000269|PubMed 11237876, ECO 0000269|PubMed 9811658}; Note=The catalytic efficiency is better for hydroxypyruvate than glyoxylate with NADPH as electron donor.; pH dependence Optimum pH is 7.5. {ECO 0000269|PubMed 11237876, ECO 0000269|PubMed 9811658}; # BioGrid 4259301 9 # CATALYTIC ACTIVITY D-gluconate + NADP(+) = 2-dehydro-D-gluconate + NADPH. {ECO:0000269|PubMed 11237876}. # CATALYTIC ACTIVITY D-glycerate + NAD(P)(+) = hydroxypyruvate + NAD(P)H. {ECO:0000269|PubMed 11237876}. # CATALYTIC ACTIVITY Glycolate + NADP(+) = glyoxylate + NADPH. {ECO:0000269|PubMed 11237876}. # EcoGene EG12272 ghrB # FUNCTION GHRB_ECOLI Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. Can also reduce 2,5-diketo-D-gluconate (25DKG) to 5-keto-D- gluconate (5KDG), 2-keto-D-gluconate (2KDG) to D-gluconate, and 2- keto-L-gulonate (2KLG) to L-idonate (IA), but it is not its physiological function. Inactive towards 2-oxoglutarate, oxaloacetate, pyruvate, 5-keto-D-gluconate, D-fructose and L- sorbose. Activity with NAD is very low. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-HAMAP. # GO_function GO:0008873 gluconate 2-dehydrogenase activity; IDA:EcoCyc. # GO_function GO:0016618 hydroxypyruvate reductase activity; IBA:GO_Central. # GO_function GO:0030267 glyoxylate reductase (NADP) activity; IDA:EcoCyc. # GO_function GO:0051287 NAD binding; IEA:InterPro. # GO_process GO:0019521 D-gluconate metabolic process; IEA:UniProtKB-KW. # GO_process GO:0046181 ketogluconate catabolic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.720 -; 2. # HAMAP MF_01667 2_Hacid_dh_C_GhrB # INDUCTION Constitutively expressed. {ECO:0000269|PubMed 11237876}. # InterPro IPR006139 D-isomer_2_OHA_DH_cat_dom # InterPro IPR006140 D-isomer_DH_NAD-bd # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR023756 Glyo/OHPyrv_Rdtase_B # InterPro IPR029753 D-isomer_DH_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00030 Pentose phosphate pathway # Organism GHRB_ECOLI Escherichia coli (strain K12) # PATRIC 32122578 VBIEscCol129921_3666 # PIR C65154 C65154 # PROSITE PS00670 D_2_HYDROXYACID_DH_2 # PROSITE PS00671 D_2_HYDROXYACID_DH_3 # Pfam PF00389 2-Hacid_dh # Pfam PF02826 2-Hacid_dh_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GHRB_ECOLI Glyoxylate/hydroxypyruvate reductase B # RefSeq NP_418009 NC_000913.3 # RefSeq WP_000805038 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18530.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAB18530.1; Type=Frameshift; Positions=324; Evidence={ECO 0000305}; # SIMILARITY Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION GHRB_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 9811658}. # SUPFAM SSF51735 SSF51735 # eggNOG COG1052 LUCA # eggNOG ENOG4105C5I Bacteria BLAST swissprot:GHRB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GHRB_ECOLI BioCyc ECOL316407:JW5656-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5656-MONOMER BioCyc EcoCyc:MONOMER-43 http://biocyc.org/getid?id=EcoCyc:MONOMER-43 BioCyc MetaCyc:MONOMER-43 http://biocyc.org/getid?id=MetaCyc:MONOMER-43 COG COG1052 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1052 DIP DIP-10997N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10997N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/0264-6021:3540707 http://dx.doi.org/10.1042/0264-6021:3540707 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.215 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.215 EC_number EC:1.1.1.79 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.79 EC_number EC:1.1.1.81 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.81 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.1.1.215 http://enzyme.expasy.org/EC/1.1.1.215 ENZYME 1.1.1.79 http://enzyme.expasy.org/EC/1.1.1.79 ENZYME 1.1.1.81 http://enzyme.expasy.org/EC/1.1.1.81 EchoBASE EB2181 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2181 EcoGene EG12272 http://www.ecogene.org/geneInfo.php?eg_id=EG12272 EnsemblBacteria AAC76577 http://www.ensemblgenomes.org/id/AAC76577 EnsemblBacteria AAC76577 http://www.ensemblgenomes.org/id/AAC76577 EnsemblBacteria BAE77742 http://www.ensemblgenomes.org/id/BAE77742 EnsemblBacteria BAE77742 http://www.ensemblgenomes.org/id/BAE77742 EnsemblBacteria BAE77742 http://www.ensemblgenomes.org/id/BAE77742 EnsemblBacteria b3553 http://www.ensemblgenomes.org/id/b3553 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0008873 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008873 GO_function GO:0016618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016618 GO_function GO:0030267 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030267 GO_function GO:0051287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051287 GO_process GO:0019521 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019521 GO_process GO:0046181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046181 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 948074 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948074 HAMAP MF_01667 http://hamap.expasy.org/unirule/MF_01667 HOGENOM HOG000136700 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000136700&db=HOGENOM6 InParanoid P37666 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37666 IntAct P37666 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37666* IntEnz 1.1.1.215 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.215 IntEnz 1.1.1.79 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.79 IntEnz 1.1.1.81 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.81 InterPro IPR006139 http://www.ebi.ac.uk/interpro/entry/IPR006139 InterPro IPR006140 http://www.ebi.ac.uk/interpro/entry/IPR006140 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR023756 http://www.ebi.ac.uk/interpro/entry/IPR023756 InterPro IPR029753 http://www.ebi.ac.uk/interpro/entry/IPR029753 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5656 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5656 KEGG_Gene eco:b3553 http://www.genome.jp/dbget-bin/www_bget?eco:b3553 KEGG_Orthology KO:K00090 http://www.genome.jp/dbget-bin/www_bget?KO:K00090 KEGG_Pathway ko00030 http://www.genome.jp/kegg-bin/show_pathway?ko00030 KEGG_Reaction rn:R01739 http://www.genome.jp/dbget-bin/www_bget?rn:R01739 OMA KSIGPDW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KSIGPDW PROSITE PS00670 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00670 PROSITE PS00671 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00671 PSORT swissprot:GHRB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GHRB_ECOLI PSORT-B swissprot:GHRB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GHRB_ECOLI PSORT2 swissprot:GHRB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GHRB_ECOLI Pfam PF00389 http://pfam.xfam.org/family/PF00389 Pfam PF02826 http://pfam.xfam.org/family/PF02826 Phobius swissprot:GHRB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GHRB_ECOLI PhylomeDB P37666 http://phylomedb.org/?seqid=P37666 ProteinModelPortal P37666 http://www.proteinmodelportal.org/query/uniprot/P37666 PubMed 11237876 http://www.ncbi.nlm.nih.gov/pubmed/11237876 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9811658 http://www.ncbi.nlm.nih.gov/pubmed/9811658 RefSeq NP_418009 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418009 RefSeq WP_000805038 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000805038 SMR P37666 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37666 STRING 511145.b3553 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3553&targetmode=cogs STRING COG1052 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1052&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB GHRB_ECOLI http://www.uniprot.org/uniprot/GHRB_ECOLI UniProtKB-AC P37666 http://www.uniprot.org/uniprot/P37666 charge swissprot:GHRB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GHRB_ECOLI eggNOG COG1052 http://eggnogapi.embl.de/nog_data/html/tree/COG1052 eggNOG ENOG4105C5I http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C5I epestfind swissprot:GHRB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GHRB_ECOLI garnier swissprot:GHRB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GHRB_ECOLI helixturnhelix swissprot:GHRB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GHRB_ECOLI hmoment swissprot:GHRB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GHRB_ECOLI iep swissprot:GHRB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GHRB_ECOLI inforesidue swissprot:GHRB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GHRB_ECOLI octanol swissprot:GHRB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GHRB_ECOLI pepcoil swissprot:GHRB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GHRB_ECOLI pepdigest swissprot:GHRB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GHRB_ECOLI pepinfo swissprot:GHRB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GHRB_ECOLI pepnet swissprot:GHRB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GHRB_ECOLI pepstats swissprot:GHRB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GHRB_ECOLI pepwheel swissprot:GHRB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GHRB_ECOLI pepwindow swissprot:GHRB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GHRB_ECOLI sigcleave swissprot:GHRB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GHRB_ECOLI ## Database ID URL or Descriptions # AltName THIH_ECOLI Dehydroglycine synthase # AltName THIH_ECOLI Tyrosine lyase # BRENDA 4.1.99.19 2026 # BioGrid 4262909 12 # CATALYTIC ACTIVITY THIH_ECOLI L-tyrosine + S-adenosyl-L-methionine + NADPH = 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP(+) + H(+). {ECO 0000269|PubMed 17403671, ECO 0000269|PubMed 17969213}. # COFACTOR THIH_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000269|PubMed 12650933, ECO 0000269|PubMed 17403671}; Note=Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L- methionine. {ECO 0000269|PubMed 12650933, ECO 0000269|PubMed 17403671}; # EcoGene EG11590 thiH # FUNCTION THIH_ECOLI Catalyzes the radical-mediated cleavage of tyrosine to 2-iminoacetate and 4-cresol. {ECO 0000269|PubMed 17403671, ECO 0000269|PubMed 17969213}. # GO_function GO:0005506 iron ion binding; IEA:InterPro. # GO_function GO:0016829 lyase activity; IDA:EcoCyc. # GO_function GO:0036355 2-iminoacetate synthase activity; IEA:UniProtKB-EC. # GO_function GO:0051536 iron-sulfur cluster binding; IDA:EcoCyc. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IDA:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0009228 thiamine biosynthetic process; IMP:EcoCyc. # GO_process GO:0009229 thiamine diphosphate biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.20.20.70 -; 1. # INTERACTION THIH_ECOLI P30139 thiG; NbExp=2; IntAct=EBI-1125553, EBI-547059; # IntAct P30140 4 # InterPro IPR007197 rSAM # InterPro IPR010722 BATS_dom # InterPro IPR012726 ThiH # InterPro IPR013785 Aldolase_TIM # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko00730 Thiamine metabolism # MISCELLANEOUS THIH_ECOLI The product 2-iminoacetate hydrates in vitro to yield glyoxylate and ammonium. # Organism THIH_ECOLI Escherichia coli (strain K12) # PATHWAY THIH_ECOLI Cofactor biosynthesis; thiamine diphosphate biosynthesis. # PATRIC 32123501 VBIEscCol129921_4103 # PIR S35121 S35121 # Pfam PF04055 Radical_SAM # Pfam PF06968 BATS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName THIH_ECOLI 2-iminoacetate synthase # RefSeq NP_418417 NC_000913.3 # RefSeq WP_000847447 NZ_LN832404.1 # SIMILARITY Belongs to the radical SAM superfamily. ThiH family. {ECO 0000305}. # SMART SM00876 BATS # SUBUNIT Forms a heterodimer with ThiG. {ECO:0000269|PubMed 12650933}. # TIGRFAMs TIGR02351 thiH # eggNOG COG1060 LUCA # eggNOG ENOG4105D41 Bacteria BLAST swissprot:THIH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:THIH_ECOLI BioCyc ECOL316407:JW3953-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3953-MONOMER BioCyc EcoCyc:THIH-MONOMER http://biocyc.org/getid?id=EcoCyc:THIH-MONOMER BioCyc MetaCyc:THIH-MONOMER http://biocyc.org/getid?id=MetaCyc:THIH-MONOMER COG COG1060 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1060 DIP DIP-6869N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-6869N DOI 10.1002/anie.200702554 http://dx.doi.org/10.1002/anie.200702554 DOI 10.1002/pro.5560070815 http://dx.doi.org/10.1002/pro.5560070815 DOI 10.1016/S0014-5793(03)00204-7 http://dx.doi.org/10.1016/S0014-5793(03)00204-7 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M700782200 http://dx.doi.org/10.1074/jbc.M700782200 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.1.99.19 {ECO:0000269|PubMed:17403671, ECO:0000269|PubMed:17969213} http://www.genome.jp/dbget-bin/www_bget?EC:4.1.99.19 {ECO:0000269|PubMed:17403671, ECO:0000269|PubMed:17969213} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M88701 http://www.ebi.ac.uk/ena/data/view/M88701 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 4.1.99.19 {ECO:0000269|PubMed:17403671, ECO:0000269|PubMed:17969213} http://enzyme.expasy.org/EC/4.1.99.19 {ECO:0000269|PubMed:17403671, ECO:0000269|PubMed:17969213} EchoBASE EB1548 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1548 EcoGene EG11590 http://www.ecogene.org/geneInfo.php?eg_id=EG11590 EnsemblBacteria AAC76964 http://www.ensemblgenomes.org/id/AAC76964 EnsemblBacteria AAC76964 http://www.ensemblgenomes.org/id/AAC76964 EnsemblBacteria BAE77330 http://www.ensemblgenomes.org/id/BAE77330 EnsemblBacteria BAE77330 http://www.ensemblgenomes.org/id/BAE77330 EnsemblBacteria BAE77330 http://www.ensemblgenomes.org/id/BAE77330 EnsemblBacteria b3990 http://www.ensemblgenomes.org/id/b3990 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GO_function GO:0036355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036355 GO_function GO:0051536 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051536 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0009228 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009228 GO_process GO:0009229 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009229 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 948494 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948494 HOGENOM HOG000270732 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000270732&db=HOGENOM6 InParanoid P30140 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30140 IntAct P30140 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P30140* IntEnz 4.1.99.19 {ECO:0000269|PubMed:17403671, ECO:0000269|PubMed:17969213} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.99.19 {ECO:0000269|PubMed:17403671, ECO:0000269|PubMed:17969213} InterPro IPR007197 http://www.ebi.ac.uk/interpro/entry/IPR007197 InterPro IPR010722 http://www.ebi.ac.uk/interpro/entry/IPR010722 InterPro IPR012726 http://www.ebi.ac.uk/interpro/entry/IPR012726 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW3953 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3953 KEGG_Gene eco:b3990 http://www.genome.jp/dbget-bin/www_bget?eco:b3990 KEGG_Orthology KO:K03150 http://www.genome.jp/dbget-bin/www_bget?KO:K03150 KEGG_Pathway ko00730 http://www.genome.jp/kegg-bin/show_pathway?ko00730 OMA EWRTDCF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EWRTDCF PSORT swissprot:THIH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:THIH_ECOLI PSORT-B swissprot:THIH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:THIH_ECOLI PSORT2 swissprot:THIH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:THIH_ECOLI Pfam PF04055 http://pfam.xfam.org/family/PF04055 Pfam PF06968 http://pfam.xfam.org/family/PF06968 Phobius swissprot:THIH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:THIH_ECOLI PhylomeDB P30140 http://phylomedb.org/?seqid=P30140 ProteinModelPortal P30140 http://www.proteinmodelportal.org/query/uniprot/P30140 PubMed 10082377 http://www.ncbi.nlm.nih.gov/pubmed/10082377 PubMed 12650933 http://www.ncbi.nlm.nih.gov/pubmed/12650933 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17403671 http://www.ncbi.nlm.nih.gov/pubmed/17403671 PubMed 17969213 http://www.ncbi.nlm.nih.gov/pubmed/17969213 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 8432721 http://www.ncbi.nlm.nih.gov/pubmed/8432721 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418417 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418417 RefSeq WP_000847447 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000847447 SMART SM00876 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00876 SMR P30140 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P30140 STRING 511145.b3990 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3990&targetmode=cogs STRING COG1060 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1060&targetmode=cogs TIGRFAMs TIGR02351 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02351 UniProtKB THIH_ECOLI http://www.uniprot.org/uniprot/THIH_ECOLI UniProtKB-AC P30140 http://www.uniprot.org/uniprot/P30140 charge swissprot:THIH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:THIH_ECOLI eggNOG COG1060 http://eggnogapi.embl.de/nog_data/html/tree/COG1060 eggNOG ENOG4105D41 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D41 epestfind swissprot:THIH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:THIH_ECOLI garnier swissprot:THIH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:THIH_ECOLI helixturnhelix swissprot:THIH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:THIH_ECOLI hmoment swissprot:THIH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:THIH_ECOLI iep swissprot:THIH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:THIH_ECOLI inforesidue swissprot:THIH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:THIH_ECOLI octanol swissprot:THIH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:THIH_ECOLI pepcoil swissprot:THIH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:THIH_ECOLI pepdigest swissprot:THIH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:THIH_ECOLI pepinfo swissprot:THIH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:THIH_ECOLI pepnet swissprot:THIH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:THIH_ECOLI pepstats swissprot:THIH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:THIH_ECOLI pepwheel swissprot:THIH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:THIH_ECOLI pepwindow swissprot:THIH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:THIH_ECOLI sigcleave swissprot:THIH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:THIH_ECOLI ## Database ID URL or Descriptions # BioGrid 4260804 370 # COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI 18420; Evidence={ECO:0000250}; # EcoGene EG11340 rfaP # FUNCTION RFAP_ECOLI Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core. {ECO 0000250}. # GO_component GO:0016020 membrane; IEA:InterPro. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016301 kinase activity; IDA:EcoCyc. # GO_function GO:0016773 phosphotransferase activity, alcohol group as acceptor; IEA:InterPro. # GO_process GO:0009244 lipopolysaccharide core region biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # IntAct P25741 7 # InterPro IPR010440 LipoPS_kinase # InterPro IPR011009 Kinase-like_dom # InterPro IPR017172 Lsacc_core_hep_kinase_RfaP # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # KEGG_Pathway ko00540 Lipopolysaccharide biosynthesis # Organism RFAP_ECOLI Escherichia coli (strain K12) # PATHWAY RFAP_ECOLI Bacterial outer membrane biogenesis; LPS core biosynthesis. # PATRIC 32122747 VBIEscCol129921_3750 # PIR C42595 C42595 # PIRSF PIRSF037318 RfaP # Pfam PF06293 Kdo # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RFAP_ECOLI Lipopolysaccharide core heptose(I) kinase RfaP # RefSeq NP_418087 NC_000913.3 # RefSeq WP_000229840 NZ_LN832404.1 # SIMILARITY Belongs to the protein kinase superfamily. KdkA/RfaP family. {ECO 0000305}. # SUPFAM SSF56112 SSF56112 # eggNOG ENOG4107543 Bacteria # eggNOG ENOG410XQAT LUCA BLAST swissprot:RFAP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RFAP_ECOLI BioCyc ECOL316407:JW3605-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3605-MONOMER BioCyc EcoCyc:EG11340-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11340-MONOMER BioCyc MetaCyc:EG11340-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11340-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M80599 http://www.ebi.ac.uk/ena/data/view/M80599 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.- http://enzyme.expasy.org/EC/2.7.1.- EchoBASE EB1316 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1316 EcoGene EG11340 http://www.ecogene.org/geneInfo.php?eg_id=EG11340 EnsemblBacteria AAC76654 http://www.ensemblgenomes.org/id/AAC76654 EnsemblBacteria AAC76654 http://www.ensemblgenomes.org/id/AAC76654 EnsemblBacteria BAE77662 http://www.ensemblgenomes.org/id/BAE77662 EnsemblBacteria BAE77662 http://www.ensemblgenomes.org/id/BAE77662 EnsemblBacteria BAE77662 http://www.ensemblgenomes.org/id/BAE77662 EnsemblBacteria b3630 http://www.ensemblgenomes.org/id/b3630 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_function GO:0016773 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016773 GO_process GO:0009244 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009244 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 948150 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948150 HOGENOM HOG000126215 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126215&db=HOGENOM6 InParanoid P25741 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P25741 IntAct P25741 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P25741* IntEnz 2.7.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1 InterPro IPR010440 http://www.ebi.ac.uk/interpro/entry/IPR010440 InterPro IPR011009 http://www.ebi.ac.uk/interpro/entry/IPR011009 InterPro IPR017172 http://www.ebi.ac.uk/interpro/entry/IPR017172 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Gene ecj:JW3605 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3605 KEGG_Gene eco:b3630 http://www.genome.jp/dbget-bin/www_bget?eco:b3630 KEGG_Orthology KO:K02848 http://www.genome.jp/dbget-bin/www_bget?KO:K02848 KEGG_Pathway ko00540 http://www.genome.jp/kegg-bin/show_pathway?ko00540 OMA LGAGQEW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LGAGQEW PSORT swissprot:RFAP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RFAP_ECOLI PSORT-B swissprot:RFAP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RFAP_ECOLI PSORT2 swissprot:RFAP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RFAP_ECOLI Pfam PF06293 http://pfam.xfam.org/family/PF06293 Phobius swissprot:RFAP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RFAP_ECOLI ProteinModelPortal P25741 http://www.proteinmodelportal.org/query/uniprot/P25741 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1732225 http://www.ncbi.nlm.nih.gov/pubmed/1732225 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418087 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418087 RefSeq WP_000229840 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000229840 STRING 511145.b3630 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3630&targetmode=cogs SUPFAM SSF56112 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56112 UniProtKB RFAP_ECOLI http://www.uniprot.org/uniprot/RFAP_ECOLI UniProtKB-AC P25741 http://www.uniprot.org/uniprot/P25741 charge swissprot:RFAP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RFAP_ECOLI eggNOG ENOG4107543 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107543 eggNOG ENOG410XQAT http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQAT epestfind swissprot:RFAP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RFAP_ECOLI garnier swissprot:RFAP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RFAP_ECOLI helixturnhelix swissprot:RFAP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RFAP_ECOLI hmoment swissprot:RFAP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RFAP_ECOLI iep swissprot:RFAP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RFAP_ECOLI inforesidue swissprot:RFAP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RFAP_ECOLI octanol swissprot:RFAP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RFAP_ECOLI pepcoil swissprot:RFAP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RFAP_ECOLI pepdigest swissprot:RFAP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RFAP_ECOLI pepinfo swissprot:RFAP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RFAP_ECOLI pepnet swissprot:RFAP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RFAP_ECOLI pepstats swissprot:RFAP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RFAP_ECOLI pepwheel swissprot:RFAP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RFAP_ECOLI pepwindow swissprot:RFAP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RFAP_ECOLI sigcleave swissprot:RFAP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RFAP_ECOLI ## Database ID URL or Descriptions # AltName MANA_ECOLI Phosphohexomutase # AltName MANA_ECOLI Phosphomannose isomerase # BioGrid 4260255 306 # CATALYTIC ACTIVITY MANA_ECOLI D-mannose 6-phosphate = D-fructose 6- phosphate. # COFACTOR MANA_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000250}; Note=Binds 1 zinc ion per subunit. {ECO 0000250}; # EcoGene EG10566 manA # FUNCTION MANA_ECOLI Involved in the conversion of glucose to GDP-L-fucose, which can be converted to L-fucose, a capsular polysaccharide. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004476 mannose-6-phosphate isomerase activity; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IEA:InterPro. # GO_process GO:0000032 cell wall mannoprotein biosynthetic process; IBA:GO_Central. # GO_process GO:0006486 protein glycosylation; IBA:GO_Central. # GO_process GO:0009242 colanic acid biosynthetic process; IMP:EcoCyc. # GO_process GO:0009298 GDP-mannose biosynthetic process; IMP:EcoCyc. # GO_process GO:0019309 mannose catabolic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 2.60.120.10 -; 3. # INTERACTION MANA_ECOLI P18196 minC; NbExp=3; IntAct=EBI-554045, EBI-554060; # IntAct P00946 19 # InterPro IPR001250 Man6P_Isoase-1 # InterPro IPR011051 RmlC_Cupin # InterPro IPR014710 RmlC-like_jellyroll # InterPro IPR016305 Mannose-6-P_Isomerase # InterPro IPR018050 Pmannose_isomerase-type1_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00051 Fructose and mannose metabolism # KEGG_Pathway ko00520 Amino sugar and nucleotide sugar metabolism # Organism MANA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10309 PTHR10309 # PATRIC 32118528 VBIEscCol129921_1684 # PIR A01172 ISECMP # PIRSF PIRSF001480 Mannose-6-phosphate_isomerase # PRINTS PR00714 MAN6PISMRASE # PROSITE PS00965 PMI_I_1 # PROSITE PS00966 PMI_I_2 # Pfam PF01238 PMI_typeI # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MANA_ECOLI Mannose-6-phosphate isomerase # RefSeq NP_416130 NC_000913.3 # RefSeq WP_001170664 NZ_LN832404.1 # SIMILARITY Belongs to the mannose-6-phosphate isomerase type 1 family. {ECO 0000305}. # SUBCELLULAR LOCATION MANA_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF51182 SSF51182 # TIGRFAMs TIGR00218 manA # eggNOG COG1482 LUCA # eggNOG ENOG4105EIP Bacteria BLAST swissprot:MANA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MANA_ECOLI BioCyc ECOL316407:JW1605-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1605-MONOMER BioCyc EcoCyc:MANNPISOM-MONOMER http://biocyc.org/getid?id=EcoCyc:MANNPISOM-MONOMER BioCyc MetaCyc:MANNPISOM-MONOMER http://biocyc.org/getid?id=MetaCyc:MANNPISOM-MONOMER COG COG1482 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1482 DIP DIP-10153N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10153N DOI 10.1016/0378-1119(84)90030-1 http://dx.doi.org/10.1016/0378-1119(84)90030-1 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.3.1.8 http://www.genome.jp/dbget-bin/www_bget?EC:5.3.1.8 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M15380 http://www.ebi.ac.uk/ena/data/view/M15380 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U35067 http://www.ebi.ac.uk/ena/data/view/U35067 ENZYME 5.3.1.8 http://enzyme.expasy.org/EC/5.3.1.8 EchoBASE EB0561 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0561 EcoGene EG10566 http://www.ecogene.org/geneInfo.php?eg_id=EG10566 EnsemblBacteria AAC74685 http://www.ensemblgenomes.org/id/AAC74685 EnsemblBacteria AAC74685 http://www.ensemblgenomes.org/id/AAC74685 EnsemblBacteria BAA15361 http://www.ensemblgenomes.org/id/BAA15361 EnsemblBacteria BAA15361 http://www.ensemblgenomes.org/id/BAA15361 EnsemblBacteria BAA15361 http://www.ensemblgenomes.org/id/BAA15361 EnsemblBacteria b1613 http://www.ensemblgenomes.org/id/b1613 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004476 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004476 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_process GO:0000032 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000032 GO_process GO:0006486 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006486 GO_process GO:0009242 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009242 GO_process GO:0009298 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009298 GO_process GO:0019309 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019309 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 2.60.120.10 http://www.cathdb.info/version/latest/superfamily/2.60.120.10 GeneID 944840 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944840 HOGENOM HOG000241278 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000241278&db=HOGENOM6 InParanoid P00946 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00946 IntAct P00946 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00946* IntEnz 5.3.1.8 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.3.1.8 InterPro IPR001250 http://www.ebi.ac.uk/interpro/entry/IPR001250 InterPro IPR011051 http://www.ebi.ac.uk/interpro/entry/IPR011051 InterPro IPR014710 http://www.ebi.ac.uk/interpro/entry/IPR014710 InterPro IPR016305 http://www.ebi.ac.uk/interpro/entry/IPR016305 InterPro IPR018050 http://www.ebi.ac.uk/interpro/entry/IPR018050 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1605 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1605 KEGG_Gene eco:b1613 http://www.genome.jp/dbget-bin/www_bget?eco:b1613 KEGG_Orthology KO:K01809 http://www.genome.jp/dbget-bin/www_bget?KO:K01809 KEGG_Pathway ko00051 http://www.genome.jp/kegg-bin/show_pathway?ko00051 KEGG_Pathway ko00520 http://www.genome.jp/kegg-bin/show_pathway?ko00520 KEGG_Reaction rn:R01819 http://www.genome.jp/dbget-bin/www_bget?rn:R01819 MINT MINT-1241491 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1241491 OMA QGEPWDT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QGEPWDT PANTHER PTHR10309 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10309 PRINTS PR00714 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00714 PROSITE PS00965 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00965 PROSITE PS00966 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00966 PSORT swissprot:MANA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MANA_ECOLI PSORT-B swissprot:MANA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MANA_ECOLI PSORT2 swissprot:MANA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MANA_ECOLI Pfam PF01238 http://pfam.xfam.org/family/PF01238 Phobius swissprot:MANA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MANA_ECOLI PhylomeDB P00946 http://phylomedb.org/?seqid=P00946 ProteinModelPortal P00946 http://www.proteinmodelportal.org/query/uniprot/P00946 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 6397402 http://www.ncbi.nlm.nih.gov/pubmed/6397402 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416130 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416130 RefSeq WP_001170664 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001170664 SMR P00946 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00946 STRING 511145.b1613 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1613&targetmode=cogs STRING COG1482 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1482&targetmode=cogs SUPFAM SSF51182 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51182 SWISS-2DPAGE P00946 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P00946 TIGRFAMs TIGR00218 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00218 UniProtKB MANA_ECOLI http://www.uniprot.org/uniprot/MANA_ECOLI UniProtKB-AC P00946 http://www.uniprot.org/uniprot/P00946 charge swissprot:MANA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MANA_ECOLI eggNOG COG1482 http://eggnogapi.embl.de/nog_data/html/tree/COG1482 eggNOG ENOG4105EIP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EIP epestfind swissprot:MANA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MANA_ECOLI garnier swissprot:MANA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MANA_ECOLI helixturnhelix swissprot:MANA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MANA_ECOLI hmoment swissprot:MANA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MANA_ECOLI iep swissprot:MANA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MANA_ECOLI inforesidue swissprot:MANA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MANA_ECOLI octanol swissprot:MANA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MANA_ECOLI pepcoil swissprot:MANA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MANA_ECOLI pepdigest swissprot:MANA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MANA_ECOLI pepinfo swissprot:MANA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MANA_ECOLI pepnet swissprot:MANA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MANA_ECOLI pepstats swissprot:MANA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MANA_ECOLI pepwheel swissprot:MANA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MANA_ECOLI pepwindow swissprot:MANA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MANA_ECOLI sigcleave swissprot:MANA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MANA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260615 263 # CDD cd15830 BamD # DISRUPTION PHENOTYPE Depletion decreases the density of outer membrane proteins, but does not significantly affect transport of lipopolysaccharides to the outer membrane. {ECO:0000269|PubMed 16824102}. # DOMAIN BAMD_ECOLI The N-terminal may interact with various proteins as a chaperone to assist in the folding and insertion of proteins into the outer membrane. The C-terminal region may serve as the link between BamA, BamC and BamE. {ECO 0000269|PubMed 22281737}. # EcoGene EG14222 bamD # FUNCTION BAMD_ECOLI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamA, the core component of the assembly machinery. Probably involved in transient protein interactions. {ECO 0000255|HAMAP-Rule MF_00922, ECO 0000269|PubMed 16824102, ECO 0000269|PubMed 20378773, ECO 0000269|PubMed 21586578, ECO 0000269|PubMed 21823654, ECO 0000269|PubMed 22281737}. # GO_component GO:1990063 Bam protein complex; IDA:EcoCyc. # GO_process GO:0043165 Gram-negative-bacterium-type cell outer membrane assembly; IDA:EcoCyc. # GO_process GO:0051205 protein insertion into membrane; IDA:EcoCyc. # GOslim_component GO:0043234 protein complex # GOslim_process GO:0008150 biological_process # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0061024 membrane organization # Gene3D 1.25.40.10 -; 1. # HAMAP MF_00922 OM_assembly_BamD # INTERACTION BAMD_ECOLI P76459 atoA; NbExp=2; IntAct=EBI-1128087, EBI-1128061; P0A940 bamA; NbExp=13; IntAct=EBI-1128087, EBI-907371; P0A903 bamC; NbExp=4; IntAct=EBI-1128087, EBI-1129043; # IntAct P0AC02 6 # InterPro IPR011990 TPR-like_helical_dom # InterPro IPR017689 BamD # Organism BAMD_ECOLI Escherichia coli (strain K12) # PATRIC 32120593 VBIEscCol129921_2695 # PDB 2YHC X-ray; 1.80 A; A=29-245 # PDB 3Q5M X-ray; 2.60 A; A=23-245 # PDB 3TGO X-ray; 2.90 A; A/B=21-245 # PDB 5AYW X-ray; 3.56 A; D=20-245 # PDB 5D0O X-ray; 2.90 A; D=1-245 # PDB 5D0Q X-ray; 3.50 A; D/H=1-245 # PDB 5EKQ X-ray; 3.39 A; D=20-245 # PIR F65037 F65037 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Outer membrane protein assembly factor BamD {ECO:0000255|HAMAP-Rule MF_00922} # RefSeq NP_417086 NC_000913.3 # RefSeq WP_000197686 NZ_LN832404.1 # SIMILARITY Belongs to the BamD family. {ECO:0000255|HAMAP- Rule MF_00922}. # SUBCELLULAR LOCATION BAMD_ECOLI Cell outer membrane {ECO 0000255|HAMAP- Rule MF_00922, ECO 0000269|PubMed 16079137}; Lipid-anchor {ECO 0000255|HAMAP-Rule MF_00922, ECO 0000269|PubMed 16079137}. # SUBUNIT BAMD_ECOLI Part of the Bam complex, which is composed of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE. Forms a subcomplex with BamC and BamE. Interacts directly with BamA. {ECO 0000255|HAMAP-Rule MF_00922, ECO 0000269|PubMed 15851030, ECO 0000269|PubMed 16079137, ECO 0000269|PubMed 16824102, ECO 0000269|PubMed 20378773, ECO 0000269|PubMed 21586578, ECO 0000269|PubMed 21823654, ECO 0000269|PubMed 21937441, ECO 0000269|PubMed 22281737}. # SUPFAM SSF48452 SSF48452 # TCDB 1.B.33.1 the outer membrane protein insertion porin (bam complex) (ompip) family # TIGRFAMs TIGR03302 OM_YfiO # eggNOG COG4105 LUCA # eggNOG ENOG4106SNF Bacteria BLAST swissprot:BAMD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BAMD_ECOLI BioCyc ECOL316407:JW2577-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2577-MONOMER BioCyc EcoCyc:G7352-MONOMER http://biocyc.org/getid?id=EcoCyc:G7352-MONOMER COG COG4105 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4105 DIP DIP-51120N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-51120N DOI 10.1016/j.cell.2005.02.015 http://dx.doi.org/10.1016/j.cell.2005.02.015 DOI 10.1021/bi2010784 http://dx.doi.org/10.1021/bi2010784 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M111.238931 http://dx.doi.org/10.1074/jbc.M111.238931 DOI 10.1074/jbc.M111.298166 http://dx.doi.org/10.1074/jbc.M111.298166 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1107/S0907444911051031 http://dx.doi.org/10.1107/S0907444911051031 DOI 10.1107/S1744309110034160 http://dx.doi.org/10.1107/S1744309110034160 DOI 10.1111/j.1365-2958.2006.05211.x http://dx.doi.org/10.1111/j.1365-2958.2006.05211.x DOI 10.1126/science.1188919 http://dx.doi.org/10.1126/science.1188919 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL Z70523 http://www.ebi.ac.uk/ena/data/view/Z70523 EchoBASE EB3974 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3974 EcoGene EG14222 http://www.ecogene.org/geneInfo.php?eg_id=EG14222 EnsemblBacteria AAC75644 http://www.ensemblgenomes.org/id/AAC75644 EnsemblBacteria AAC75644 http://www.ensemblgenomes.org/id/AAC75644 EnsemblBacteria BAA16480 http://www.ensemblgenomes.org/id/BAA16480 EnsemblBacteria BAA16480 http://www.ensemblgenomes.org/id/BAA16480 EnsemblBacteria BAA16480 http://www.ensemblgenomes.org/id/BAA16480 EnsemblBacteria b2595 http://www.ensemblgenomes.org/id/b2595 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:1990063 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990063 GO_process GO:0043165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043165 GO_process GO:0051205 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051205 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0061024 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024 Gene3D 1.25.40.10 http://www.cathdb.info/version/latest/superfamily/1.25.40.10 GeneID 947086 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947086 HAMAP MF_00922 http://hamap.expasy.org/unirule/MF_00922 HOGENOM HOG000260923 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260923&db=HOGENOM6 InParanoid P0AC02 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AC02 IntAct P0AC02 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AC02* InterPro IPR011990 http://www.ebi.ac.uk/interpro/entry/IPR011990 InterPro IPR017689 http://www.ebi.ac.uk/interpro/entry/IPR017689 KEGG_Gene ecj:JW2577 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2577 KEGG_Gene eco:b2595 http://www.genome.jp/dbget-bin/www_bget?eco:b2595 KEGG_Orthology KO:K05807 http://www.genome.jp/dbget-bin/www_bget?KO:K05807 MINT MINT-8141303 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8141303 OMA IHVADYY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IHVADYY PDB 2YHC http://www.ebi.ac.uk/pdbe-srv/view/entry/2YHC PDB 3Q5M http://www.ebi.ac.uk/pdbe-srv/view/entry/3Q5M PDB 3TGO http://www.ebi.ac.uk/pdbe-srv/view/entry/3TGO PDB 5AYW http://www.ebi.ac.uk/pdbe-srv/view/entry/5AYW PDB 5D0O http://www.ebi.ac.uk/pdbe-srv/view/entry/5D0O PDB 5D0Q http://www.ebi.ac.uk/pdbe-srv/view/entry/5D0Q PDB 5EKQ http://www.ebi.ac.uk/pdbe-srv/view/entry/5EKQ PDBsum 2YHC http://www.ebi.ac.uk/pdbsum/2YHC PDBsum 3Q5M http://www.ebi.ac.uk/pdbsum/3Q5M PDBsum 3TGO http://www.ebi.ac.uk/pdbsum/3TGO PDBsum 5AYW http://www.ebi.ac.uk/pdbsum/5AYW PDBsum 5D0O http://www.ebi.ac.uk/pdbsum/5D0O PDBsum 5D0Q http://www.ebi.ac.uk/pdbsum/5D0Q PDBsum 5EKQ http://www.ebi.ac.uk/pdbsum/5EKQ PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:BAMD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BAMD_ECOLI PSORT-B swissprot:BAMD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BAMD_ECOLI PSORT2 swissprot:BAMD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BAMD_ECOLI Phobius swissprot:BAMD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BAMD_ECOLI PhylomeDB P0AC02 http://phylomedb.org/?seqid=P0AC02 ProteinModelPortal P0AC02 http://www.proteinmodelportal.org/query/uniprot/P0AC02 PubMed 15851030 http://www.ncbi.nlm.nih.gov/pubmed/15851030 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16824102 http://www.ncbi.nlm.nih.gov/pubmed/16824102 PubMed 20378773 http://www.ncbi.nlm.nih.gov/pubmed/20378773 PubMed 21139201 http://www.ncbi.nlm.nih.gov/pubmed/21139201 PubMed 21586578 http://www.ncbi.nlm.nih.gov/pubmed/21586578 PubMed 21823654 http://www.ncbi.nlm.nih.gov/pubmed/21823654 PubMed 21937441 http://www.ncbi.nlm.nih.gov/pubmed/21937441 PubMed 22281737 http://www.ncbi.nlm.nih.gov/pubmed/22281737 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417086 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417086 RefSeq WP_000197686 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000197686 SMR P0AC02 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AC02 STRING 511145.b2595 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2595&targetmode=cogs STRING COG4105 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4105&targetmode=cogs SUPFAM SSF48452 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48452 TCDB 1.B.33.1 http://www.tcdb.org/search/result.php?tc=1.B.33.1 TIGRFAMs TIGR03302 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03302 UniProtKB BAMD_ECOLI http://www.uniprot.org/uniprot/BAMD_ECOLI UniProtKB-AC P0AC02 http://www.uniprot.org/uniprot/P0AC02 charge swissprot:BAMD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BAMD_ECOLI eggNOG COG4105 http://eggnogapi.embl.de/nog_data/html/tree/COG4105 eggNOG ENOG4106SNF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106SNF epestfind swissprot:BAMD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BAMD_ECOLI garnier swissprot:BAMD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BAMD_ECOLI helixturnhelix swissprot:BAMD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BAMD_ECOLI hmoment swissprot:BAMD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BAMD_ECOLI iep swissprot:BAMD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BAMD_ECOLI inforesidue swissprot:BAMD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BAMD_ECOLI octanol swissprot:BAMD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BAMD_ECOLI pepcoil swissprot:BAMD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BAMD_ECOLI pepdigest swissprot:BAMD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BAMD_ECOLI pepinfo swissprot:BAMD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BAMD_ECOLI pepnet swissprot:BAMD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BAMD_ECOLI pepstats swissprot:BAMD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BAMD_ECOLI pepwheel swissprot:BAMD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BAMD_ECOLI pepwindow swissprot:BAMD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BAMD_ECOLI sigcleave swissprot:BAMD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BAMD_ECOLI ## Database ID URL or Descriptions # AltName GLMS_ECOLI D-fructose-6-phosphate amidotransferase # AltName GLMS_ECOLI GFAT # AltName GLMS_ECOLI Glucosamine-6-phosphate synthase # AltName GLMS_ECOLI Hexosephosphate aminotransferase # AltName GLMS_ECOLI L-glutamine--D-fructose-6-phosphate amidotransferase # BRENDA 2.6.1.16 2026 # BioGrid 4262136 508 # CATALYTIC ACTIVITY GLMS_ECOLI L-glutamine + D-fructose 6-phosphate = L- glutamate + D-glucosamine 6-phosphate. # EcoGene EG10382 glmS # FUNCTION GLMS_ECOLI Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0004360 glutamine-fructose-6-phosphate transaminase (isomerizing) activity; IDA:EcoCyc. # GO_function GO:0030246 carbohydrate binding; IEA:UniProtKB-HAMAP. # GO_process GO:0005975 carbohydrate metabolic process; IEA:UniProtKB-HAMAP. # GO_process GO:0006002 fructose 6-phosphate metabolic process; IBA:GO_Central. # GO_process GO:0006048 UDP-N-acetylglucosamine biosynthetic process; IMP:EcoCyc. # GO_process GO:0006541 glutamine metabolic process; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.60.20.10 -; 1. # HAMAP MF_00164 GlmS # INDUCTION GLMS_ECOLI Post-transcriptionally regulated by the GlmY/GlmZ sRNA regulatory cascade. The sRNA GlmZ, together with Hfq, directly activates glmS mRNA translation through base-pairing. A second sRNA, GlmY, positively regulates glmS indirectly, by sequestering the adapter protein RapZ and protecting GlmZ from RNA cleavage. {ECO 0000269|PubMed 18334534, ECO 0000269|PubMed 18351803, ECO 0000269|PubMed 23475961}. # INTERACTION GLMS_ECOLI P76093 ynbD; NbExp=3; IntAct=EBI-551022, EBI-551038; # IntAct P17169 8 # InterPro IPR001347 SIS # InterPro IPR005855 GlmS_trans # InterPro IPR017932 GATase_2_dom # InterPro IPR029055 Ntn_hydrolases_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # KEGG_Pathway ko00250 Alanine, aspartate and glutamate metabolism # KEGG_Pathway ko00520 Amino sugar and nucleotide sugar metabolism # Organism GLMS_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10937:SF0 PTHR10937:SF0 # PATRIC 32122955 VBIEscCol129921_3853 # PDB 1JXA X-ray; 3.10 A; A/B/C=2-609 # PDB 1MOQ X-ray; 1.57 A; A=242-609 # PDB 1MOR X-ray; 1.90 A; A=242-609 # PDB 1MOS X-ray; 2.00 A; A=242-609 # PDB 1XFF X-ray; 1.80 A; A/B=2-241 # PDB 1XFG X-ray; 1.85 A; A/B=2-241 # PDB 2J6H X-ray; 2.35 A; A/B=2-609 # PDB 2VF4 X-ray; 2.95 A; X=2-609 # PDB 2VF5 X-ray; 2.90 A; X=2-609 # PDB 3OOJ X-ray; 2.50 A; A/B/C/D/E/F/G/H=3-609 # PDB 4AMV X-ray; 2.05 A; A/B/C=1-609 # PIR B65176 XNECGM # PROSITE PS51278 GATASE_TYPE_2 # PROSITE PS51464 SIS; 2 # Pfam PF01380 SIS; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLMS_ECOLI Glutamine--fructose-6-phosphate aminotransferase [isomerizing] # RefSeq NP_418185 NC_000913.3 # RefSeq WP_000334099 NZ_LN832404.1 # SIMILARITY Contains 1 glutamine amidotransferase type-2 domain. {ECO 0000305}. # SIMILARITY Contains 2 SIS domains. {ECO 0000305}. # SUBCELLULAR LOCATION GLMS_ECOLI Cytoplasm. # SUBUNIT GLMS_ECOLI Homodimer. # SUPFAM SSF56235 SSF56235 # TIGRFAMs TIGR01135 glmS # eggNOG COG0449 LUCA # eggNOG ENOG4105C46 Bacteria BLAST swissprot:GLMS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLMS_ECOLI BioCyc ECOL316407:JW3707-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3707-MONOMER BioCyc EcoCyc:L-GLN-FRUCT-6-P-AMINOTRANS-MONOMER http://biocyc.org/getid?id=EcoCyc:L-GLN-FRUCT-6-P-AMINOTRANS-MONOMER BioCyc MetaCyc:L-GLN-FRUCT-6-P-AMINOTRANS-MONOMER http://biocyc.org/getid?id=MetaCyc:L-GLN-FRUCT-6-P-AMINOTRANS-MONOMER COG COG0449 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0449 DIP DIP-9775N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9775N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1016/0300-9084(88)90073-9 http://dx.doi.org/10.1016/0300-9084(88)90073-9 DOI 10.1016/S0969-2126(96)00087-1 http://dx.doi.org/10.1016/S0969-2126(96)00087-1 DOI 10.1016/S0969-2126(98)00105-1 http://dx.doi.org/10.1016/S0969-2126(98)00105-1 DOI 10.1038/297601a0 http://dx.doi.org/10.1038/297601a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2240799 http://dx.doi.org/10.1042/bj2240799 DOI 10.1042/bj2340111 http://dx.doi.org/10.1042/bj2340111 DOI 10.1093/nar/gkn091 http://dx.doi.org/10.1093/nar/gkn091 DOI 10.1101/gad.210112.112 http://dx.doi.org/10.1101/gad.210112.112 DOI 10.1110/ps.8.3.596 http://dx.doi.org/10.1110/ps.8.3.596 DOI 10.1111/j.1432-1033.1991.tb16271.x http://dx.doi.org/10.1111/j.1432-1033.1991.tb16271.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pbio.0060064 http://dx.doi.org/10.1371/journal.pbio.0060064 EC_number EC:2.6.1.16 http://www.genome.jp/dbget-bin/www_bget?EC:2.6.1.16 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M18980 http://www.ebi.ac.uk/ena/data/view/M18980 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00620 http://www.ebi.ac.uk/ena/data/view/V00620 EMBL X01631 http://www.ebi.ac.uk/ena/data/view/X01631 ENZYME 2.6.1.16 http://enzyme.expasy.org/EC/2.6.1.16 EchoBASE EB0377 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0377 EcoGene EG10382 http://www.ecogene.org/geneInfo.php?eg_id=EG10382 EnsemblBacteria AAC76752 http://www.ensemblgenomes.org/id/AAC76752 EnsemblBacteria AAC76752 http://www.ensemblgenomes.org/id/AAC76752 EnsemblBacteria BAE77559 http://www.ensemblgenomes.org/id/BAE77559 EnsemblBacteria BAE77559 http://www.ensemblgenomes.org/id/BAE77559 EnsemblBacteria BAE77559 http://www.ensemblgenomes.org/id/BAE77559 EnsemblBacteria b3729 http://www.ensemblgenomes.org/id/b3729 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004360 GO_function GO:0030246 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030246 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GO_process GO:0006002 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006002 GO_process GO:0006048 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006048 GO_process GO:0006541 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006541 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.60.20.10 http://www.cathdb.info/version/latest/superfamily/3.60.20.10 GeneID 948241 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948241 HAMAP MF_00164 http://hamap.expasy.org/unirule/MF_00164 HOGENOM HOG000258898 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000258898&db=HOGENOM6 InParanoid P17169 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P17169 IntAct P17169 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P17169* IntEnz 2.6.1.16 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.6.1.16 InterPro IPR001347 http://www.ebi.ac.uk/interpro/entry/IPR001347 InterPro IPR005855 http://www.ebi.ac.uk/interpro/entry/IPR005855 InterPro IPR017932 http://www.ebi.ac.uk/interpro/entry/IPR017932 InterPro IPR029055 http://www.ebi.ac.uk/interpro/entry/IPR029055 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW3707 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3707 KEGG_Gene eco:b3729 http://www.genome.jp/dbget-bin/www_bget?eco:b3729 KEGG_Orthology KO:K00820 http://www.genome.jp/dbget-bin/www_bget?KO:K00820 KEGG_Pathway ko00250 http://www.genome.jp/kegg-bin/show_pathway?ko00250 KEGG_Pathway ko00520 http://www.genome.jp/kegg-bin/show_pathway?ko00520 KEGG_Reaction rn:R00768 http://www.genome.jp/dbget-bin/www_bget?rn:R00768 MINT MINT-1238536 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1238536 OMA GEFFCAS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GEFFCAS PANTHER PTHR10937:SF0 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10937:SF0 PDB 1JXA http://www.ebi.ac.uk/pdbe-srv/view/entry/1JXA PDB 1MOQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1MOQ PDB 1MOR http://www.ebi.ac.uk/pdbe-srv/view/entry/1MOR PDB 1MOS http://www.ebi.ac.uk/pdbe-srv/view/entry/1MOS PDB 1XFF http://www.ebi.ac.uk/pdbe-srv/view/entry/1XFF PDB 1XFG http://www.ebi.ac.uk/pdbe-srv/view/entry/1XFG PDB 2J6H http://www.ebi.ac.uk/pdbe-srv/view/entry/2J6H PDB 2VF4 http://www.ebi.ac.uk/pdbe-srv/view/entry/2VF4 PDB 2VF5 http://www.ebi.ac.uk/pdbe-srv/view/entry/2VF5 PDB 3OOJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3OOJ PDB 4AMV http://www.ebi.ac.uk/pdbe-srv/view/entry/4AMV PDBsum 1JXA http://www.ebi.ac.uk/pdbsum/1JXA PDBsum 1MOQ http://www.ebi.ac.uk/pdbsum/1MOQ PDBsum 1MOR http://www.ebi.ac.uk/pdbsum/1MOR PDBsum 1MOS http://www.ebi.ac.uk/pdbsum/1MOS PDBsum 1XFF http://www.ebi.ac.uk/pdbsum/1XFF PDBsum 1XFG http://www.ebi.ac.uk/pdbsum/1XFG PDBsum 2J6H http://www.ebi.ac.uk/pdbsum/2J6H PDBsum 2VF4 http://www.ebi.ac.uk/pdbsum/2VF4 PDBsum 2VF5 http://www.ebi.ac.uk/pdbsum/2VF5 PDBsum 3OOJ http://www.ebi.ac.uk/pdbsum/3OOJ PDBsum 4AMV http://www.ebi.ac.uk/pdbsum/4AMV PROSITE PS51278 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51278 PROSITE PS51464 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51464 PSORT swissprot:GLMS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLMS_ECOLI PSORT-B swissprot:GLMS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLMS_ECOLI PSORT2 swissprot:GLMS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLMS_ECOLI Pfam PF01380 http://pfam.xfam.org/family/PF01380 Phobius swissprot:GLMS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLMS_ECOLI PhylomeDB P17169 http://phylomedb.org/?seqid=P17169 ProteinModelPortal P17169 http://www.proteinmodelportal.org/query/uniprot/P17169 PubMed 10091662 http://www.ncbi.nlm.nih.gov/pubmed/10091662 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18334534 http://www.ncbi.nlm.nih.gov/pubmed/18334534 PubMed 18351803 http://www.ncbi.nlm.nih.gov/pubmed/18351803 PubMed 1915361 http://www.ncbi.nlm.nih.gov/pubmed/1915361 PubMed 23475961 http://www.ncbi.nlm.nih.gov/pubmed/23475961 PubMed 2826397 http://www.ncbi.nlm.nih.gov/pubmed/2826397 PubMed 3010949 http://www.ncbi.nlm.nih.gov/pubmed/3010949 PubMed 3134953 http://www.ncbi.nlm.nih.gov/pubmed/3134953 PubMed 6283361 http://www.ncbi.nlm.nih.gov/pubmed/6283361 PubMed 6395859 http://www.ncbi.nlm.nih.gov/pubmed/6395859 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 8805567 http://www.ncbi.nlm.nih.gov/pubmed/8805567 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9739095 http://www.ncbi.nlm.nih.gov/pubmed/9739095 RefSeq NP_418185 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418185 RefSeq WP_000334099 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000334099 SMR P17169 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P17169 STRING 511145.b3729 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3729&targetmode=cogs STRING COG0449 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0449&targetmode=cogs SUPFAM SSF56235 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56235 TIGRFAMs TIGR01135 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01135 UniProtKB GLMS_ECOLI http://www.uniprot.org/uniprot/GLMS_ECOLI UniProtKB-AC P17169 http://www.uniprot.org/uniprot/P17169 charge swissprot:GLMS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLMS_ECOLI eggNOG COG0449 http://eggnogapi.embl.de/nog_data/html/tree/COG0449 eggNOG ENOG4105C46 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C46 epestfind swissprot:GLMS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLMS_ECOLI garnier swissprot:GLMS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLMS_ECOLI helixturnhelix swissprot:GLMS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLMS_ECOLI hmoment swissprot:GLMS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLMS_ECOLI iep swissprot:GLMS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLMS_ECOLI inforesidue swissprot:GLMS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLMS_ECOLI octanol swissprot:GLMS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLMS_ECOLI pepcoil swissprot:GLMS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLMS_ECOLI pepdigest swissprot:GLMS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLMS_ECOLI pepinfo swissprot:GLMS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLMS_ECOLI pepnet swissprot:GLMS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLMS_ECOLI pepstats swissprot:GLMS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLMS_ECOLI pepwheel swissprot:GLMS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLMS_ECOLI pepwindow swissprot:GLMS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLMS_ECOLI sigcleave swissprot:GLMS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLMS_ECOLI ## Database ID URL or Descriptions # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG14428 ypdJ # Organism YPDJ_ECOLI Escherichia coli (strain K12) # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YPDJ_ECOLI Putative uncharacterized protein YpdJ BLAST swissprot:YPDJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YPDJ_ECOLI BioCyc ECOL316407:JW5386-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5386-MONOMER BioCyc EcoCyc:MONOMER0-2683 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2683 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14428 http://www.ecogene.org/geneInfo.php?eg_id=EG14428 EnsemblBacteria BAE76703 http://www.ensemblgenomes.org/id/BAE76703 EnsemblBacteria BAE76703 http://www.ensemblgenomes.org/id/BAE76703 EnsemblBacteria BAE76703 http://www.ensemblgenomes.org/id/BAE76703 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv KEGG_Gene ecj:JW5386 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5386 PSORT swissprot:YPDJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YPDJ_ECOLI PSORT-B swissprot:YPDJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YPDJ_ECOLI PSORT2 swissprot:YPDJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YPDJ_ECOLI Phobius swissprot:YPDJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YPDJ_ECOLI ProteinModelPortal Q2EET0 http://www.proteinmodelportal.org/query/uniprot/Q2EET0 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 STRING 316407.85675378 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85675378&targetmode=cogs UniProtKB YPDJ_ECOLI http://www.uniprot.org/uniprot/YPDJ_ECOLI UniProtKB-AC Q2EET0 http://www.uniprot.org/uniprot/Q2EET0 charge swissprot:YPDJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YPDJ_ECOLI epestfind swissprot:YPDJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YPDJ_ECOLI garnier swissprot:YPDJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YPDJ_ECOLI helixturnhelix swissprot:YPDJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YPDJ_ECOLI hmoment swissprot:YPDJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YPDJ_ECOLI iep swissprot:YPDJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YPDJ_ECOLI inforesidue swissprot:YPDJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YPDJ_ECOLI octanol swissprot:YPDJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YPDJ_ECOLI pepcoil swissprot:YPDJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YPDJ_ECOLI pepdigest swissprot:YPDJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YPDJ_ECOLI pepinfo swissprot:YPDJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YPDJ_ECOLI pepnet swissprot:YPDJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YPDJ_ECOLI pepstats swissprot:YPDJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YPDJ_ECOLI pepwheel swissprot:YPDJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YPDJ_ECOLI pepwindow swissprot:YPDJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YPDJ_ECOLI sigcleave swissprot:YPDJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YPDJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4263368 320 # CATALYTIC ACTIVITY FABD_ECOLI Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein]. # EcoGene EG11317 fabD # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004314 [acyl-carrier-protein] S-malonyltransferase activity; IMP:EcoCyc. # GO_process GO:0006633 fatty acid biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.366.10 -; 2. # IntAct P0AAI9 4 # InterPro IPR001227 Ac_transferase_dom # InterPro IPR004410 Malonyl_CoA-ACP_transAc_FabD # InterPro IPR014043 Acyl_transferase # InterPro IPR016035 Acyl_Trfase/lysoPLipase # InterPro IPR016036 Malonyl_transacylase_ACP-bd # InterPro IPR020801 PKS_acyl_transferase # InterPro IPR024925 Malonyl_CoA-ACP_transAc # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01004 Lipid biosynthesis proteins # KEGG_Pathway ko00061 Fatty acid biosynthesis # Organism FABD_ECOLI Escherichia coli (strain K12) # PATHWAY FABD_ECOLI Lipid metabolism; fatty acid biosynthesis. # PATRIC 32117425 VBIEscCol129921_1135 # PDB 1MLA X-ray; 1.50 A; A=1-309 # PDB 2G1H X-ray; 1.86 A; A=2-309 # PDB 2G2O X-ray; 1.76 A; A=2-309 # PDB 2G2Y X-ray; 2.26 A; A=2-309 # PDB 2G2Z X-ray; 2.80 A; A=2-309 # PIR B41856 B41856 # PIRSF PIRSF000446 Mct # Pfam PF00698 Acyl_transf_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FABD_ECOLI Malonyl CoA-acyl carrier protein transacylase # RefSeq NP_415610 NC_000913.3 # RefSeq WP_000191372 NZ_LN832404.1 # SIMILARITY Belongs to the FabD family. {ECO 0000305}. # SMART SM00827 PKS_AT # SUPFAM SSF52151 SSF52151; 2 # SUPFAM SSF55048 SSF55048 # TIGRFAMs TIGR00128 fabD # eggNOG COG0331 LUCA # eggNOG ENOG4105CJF Bacteria BLAST swissprot:FABD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FABD_ECOLI BioCyc ECOL316407:JW1078-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1078-MONOMER BioCyc EcoCyc:MALONYL-COA-ACP-TRANSACYL-MONOMER http://biocyc.org/getid?id=EcoCyc:MALONYL-COA-ACP-TRANSACYL-MONOMER BioCyc MetaCyc:MALONYL-COA-ACP-TRANSACYL-MONOMER http://biocyc.org/getid?id=MetaCyc:MALONYL-COA-ACP-TRANSACYL-MONOMER COG COG0331 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0331 DIP DIP-47923N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47923N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1007/BF00298970 http://dx.doi.org/10.1007/BF00298970 DOI 10.1016/0014-5793(92)80128-4 http://dx.doi.org/10.1016/0014-5793(92)80128-4 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.270.22.12961 http://dx.doi.org/10.1074/jbc.270.22.12961 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.39 http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.39 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M84991 http://www.ebi.ac.uk/ena/data/view/M84991 EMBL M87040 http://www.ebi.ac.uk/ena/data/view/M87040 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL Z11565 http://www.ebi.ac.uk/ena/data/view/Z11565 ENZYME 2.3.1.39 http://enzyme.expasy.org/EC/2.3.1.39 EchoBASE EB1293 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1293 EcoGene EG11317 http://www.ecogene.org/geneInfo.php?eg_id=EG11317 EnsemblBacteria AAC74176 http://www.ensemblgenomes.org/id/AAC74176 EnsemblBacteria AAC74176 http://www.ensemblgenomes.org/id/AAC74176 EnsemblBacteria BAA35900 http://www.ensemblgenomes.org/id/BAA35900 EnsemblBacteria BAA35900 http://www.ensemblgenomes.org/id/BAA35900 EnsemblBacteria BAA35900 http://www.ensemblgenomes.org/id/BAA35900 EnsemblBacteria b1092 http://www.ensemblgenomes.org/id/b1092 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004314 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004314 GO_process GO:0006633 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006633 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.366.10 http://www.cathdb.info/version/latest/superfamily/3.40.366.10 GeneID 945766 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945766 HOGENOM HOG000036503 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000036503&db=HOGENOM6 InParanoid P0AAI9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAI9 IntAct P0AAI9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAI9* IntEnz 2.3.1.39 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.39 InterPro IPR001227 http://www.ebi.ac.uk/interpro/entry/IPR001227 InterPro IPR004410 http://www.ebi.ac.uk/interpro/entry/IPR004410 InterPro IPR014043 http://www.ebi.ac.uk/interpro/entry/IPR014043 InterPro IPR016035 http://www.ebi.ac.uk/interpro/entry/IPR016035 InterPro IPR016036 http://www.ebi.ac.uk/interpro/entry/IPR016036 InterPro IPR020801 http://www.ebi.ac.uk/interpro/entry/IPR020801 InterPro IPR024925 http://www.ebi.ac.uk/interpro/entry/IPR024925 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01004 http://www.genome.jp/dbget-bin/www_bget?ko01004 KEGG_Gene ecj:JW1078 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1078 KEGG_Gene eco:b1092 http://www.genome.jp/dbget-bin/www_bget?eco:b1092 KEGG_Orthology KO:K00645 http://www.genome.jp/dbget-bin/www_bget?KO:K00645 KEGG_Pathway ko00061 http://www.genome.jp/kegg-bin/show_pathway?ko00061 KEGG_Reaction rn:R01626 http://www.genome.jp/dbget-bin/www_bget?rn:R01626 OMA FHCALMQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FHCALMQ PDB 1MLA http://www.ebi.ac.uk/pdbe-srv/view/entry/1MLA PDB 2G1H http://www.ebi.ac.uk/pdbe-srv/view/entry/2G1H PDB 2G2O http://www.ebi.ac.uk/pdbe-srv/view/entry/2G2O PDB 2G2Y http://www.ebi.ac.uk/pdbe-srv/view/entry/2G2Y PDB 2G2Z http://www.ebi.ac.uk/pdbe-srv/view/entry/2G2Z PDBsum 1MLA http://www.ebi.ac.uk/pdbsum/1MLA PDBsum 2G1H http://www.ebi.ac.uk/pdbsum/2G1H PDBsum 2G2O http://www.ebi.ac.uk/pdbsum/2G2O PDBsum 2G2Y http://www.ebi.ac.uk/pdbsum/2G2Y PDBsum 2G2Z http://www.ebi.ac.uk/pdbsum/2G2Z PSORT swissprot:FABD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FABD_ECOLI PSORT-B swissprot:FABD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FABD_ECOLI PSORT2 swissprot:FABD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FABD_ECOLI Pfam PF00698 http://pfam.xfam.org/family/PF00698 Phobius swissprot:FABD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FABD_ECOLI PhylomeDB P0AAI9 http://phylomedb.org/?seqid=P0AAI9 ProteinModelPortal P0AAI9 http://www.proteinmodelportal.org/query/uniprot/P0AAI9 PubMed 1314802 http://www.ncbi.nlm.nih.gov/pubmed/1314802 PubMed 1339356 http://www.ncbi.nlm.nih.gov/pubmed/1339356 PubMed 1556094 http://www.ncbi.nlm.nih.gov/pubmed/1556094 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7700236 http://www.ncbi.nlm.nih.gov/pubmed/7700236 PubMed 7768883 http://www.ncbi.nlm.nih.gov/pubmed/7768883 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_415610 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415610 RefSeq WP_000191372 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000191372 SMART SM00827 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00827 SMR P0AAI9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAI9 STRING 511145.b1092 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1092&targetmode=cogs STRING COG0331 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0331&targetmode=cogs SUPFAM SSF52151 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52151 SUPFAM SSF55048 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55048 SWISS-2DPAGE P0AAI9 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AAI9 TIGRFAMs TIGR00128 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00128 UniProtKB FABD_ECOLI http://www.uniprot.org/uniprot/FABD_ECOLI UniProtKB-AC P0AAI9 http://www.uniprot.org/uniprot/P0AAI9 charge swissprot:FABD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FABD_ECOLI eggNOG COG0331 http://eggnogapi.embl.de/nog_data/html/tree/COG0331 eggNOG ENOG4105CJF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CJF epestfind swissprot:FABD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FABD_ECOLI garnier swissprot:FABD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FABD_ECOLI helixturnhelix swissprot:FABD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FABD_ECOLI hmoment swissprot:FABD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FABD_ECOLI iep swissprot:FABD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FABD_ECOLI inforesidue swissprot:FABD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FABD_ECOLI octanol swissprot:FABD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FABD_ECOLI pepcoil swissprot:FABD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FABD_ECOLI pepdigest swissprot:FABD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FABD_ECOLI pepinfo swissprot:FABD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FABD_ECOLI pepnet swissprot:FABD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FABD_ECOLI pepstats swissprot:FABD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FABD_ECOLI pepwheel swissprot:FABD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FABD_ECOLI pepwindow swissprot:FABD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FABD_ECOLI sigcleave swissprot:FABD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FABD_ECOLI ## Database ID URL or Descriptions # AltName FIMA1_ECOLI Type-1A pilin # BioGrid 4262746 6 # EcoGene EG10308 fimA # FUNCTION FIMA1_ECOLI Fimbriae (also called pili), polar filaments radiating from the surface of the bacterium to a length of 0.5-1.5 micrometers and numbering 100-300 per cell, enable bacteria to colonize the epithelium of specific host organs. # GO_component GO:0009289 pilus; IEA:UniProtKB-SubCell. # GO_process GO:0007155 cell adhesion; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0007155 cell adhesion # Gene3D 2.60.40.1090 -; 1. # InterPro IPR000259 Adhesion_dom_fimbrial # InterPro IPR008966 Adhesion_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko05133 Pertussis # Organism FIMA1_ECOLI Escherichia coli (strain K12) # PATRIC 32124224 VBIEscCol129921_4455 # PDB 2JTY NMR; -; A=24-182 # PDB 2M5G NMR; -; A=24-182 # PDB 2N7H NMR; -; A/B/C/D/E/F=24-182 # PDB 3SQB X-ray; 3.20 A; B/D/F/H=37-182 # PDB 4DWH X-ray; 2.50 A; B/D=41-182 # PIR S56539 YQECT1 # Pfam PF00419 Fimbrial # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FIMA1_ECOLI Type-1 fimbrial protein, A chain # RefSeq NP_418734 NC_000913.3 # RefSeq WP_000695564 NZ_LN832404.1 # SIMILARITY Belongs to the fimbrial protein family. {ECO 0000305}. # SUBCELLULAR LOCATION FIMA1_ECOLI Fimbrium. # SUPFAM SSF49401 SSF49401 # eggNOG ENOG4108RQP Bacteria # eggNOG ENOG4111KX6 LUCA BLAST swissprot:FIMA1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FIMA1_ECOLI BioCyc ECOL316407:JW4277-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4277-MONOMER BioCyc EcoCyc:EG10308-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10308-MONOMER COG COG3539 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3539 DIP DIP-9609N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9609N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1111/j.1432-1033.1984.tb08386.x http://dx.doi.org/10.1111/j.1432-1033.1984.tb08386.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M27603 http://www.ebi.ac.uk/ena/data/view/M27603 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X00981 http://www.ebi.ac.uk/ena/data/view/X00981 EchoBASE EB0304 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0304 EcoGene EG10308 http://www.ecogene.org/geneInfo.php?eg_id=EG10308 EnsemblBacteria AAC77270 http://www.ensemblgenomes.org/id/AAC77270 EnsemblBacteria AAC77270 http://www.ensemblgenomes.org/id/AAC77270 EnsemblBacteria BAE78307 http://www.ensemblgenomes.org/id/BAE78307 EnsemblBacteria BAE78307 http://www.ensemblgenomes.org/id/BAE78307 EnsemblBacteria BAE78307 http://www.ensemblgenomes.org/id/BAE78307 EnsemblBacteria b4314 http://www.ensemblgenomes.org/id/b4314 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009289 GO_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 Gene3D 2.60.40.1090 http://www.cathdb.info/version/latest/superfamily/2.60.40.1090 GeneID 948838 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948838 HOGENOM HOG000260127 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260127&db=HOGENOM6 InParanoid P04128 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P04128 InterPro IPR000259 http://www.ebi.ac.uk/interpro/entry/IPR000259 InterPro IPR008966 http://www.ebi.ac.uk/interpro/entry/IPR008966 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW4277 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4277 KEGG_Gene eco:b4314 http://www.genome.jp/dbget-bin/www_bget?eco:b4314 KEGG_Orthology KO:K07345 http://www.genome.jp/dbget-bin/www_bget?KO:K07345 KEGG_Pathway ko05133 http://www.genome.jp/kegg-bin/show_pathway?ko05133 OMA NDCDTSV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NDCDTSV PDB 2JTY http://www.ebi.ac.uk/pdbe-srv/view/entry/2JTY PDB 2M5G http://www.ebi.ac.uk/pdbe-srv/view/entry/2M5G PDB 2N7H http://www.ebi.ac.uk/pdbe-srv/view/entry/2N7H PDB 3SQB http://www.ebi.ac.uk/pdbe-srv/view/entry/3SQB PDB 4DWH http://www.ebi.ac.uk/pdbe-srv/view/entry/4DWH PDBsum 2JTY http://www.ebi.ac.uk/pdbsum/2JTY PDBsum 2M5G http://www.ebi.ac.uk/pdbsum/2M5G PDBsum 2N7H http://www.ebi.ac.uk/pdbsum/2N7H PDBsum 3SQB http://www.ebi.ac.uk/pdbsum/3SQB PDBsum 4DWH http://www.ebi.ac.uk/pdbsum/4DWH PSORT swissprot:FIMA1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FIMA1_ECOLI PSORT-B swissprot:FIMA1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FIMA1_ECOLI PSORT2 swissprot:FIMA1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FIMA1_ECOLI Pfam PF00419 http://pfam.xfam.org/family/PF00419 Phobius swissprot:FIMA1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FIMA1_ECOLI PhylomeDB P04128 http://phylomedb.org/?seqid=P04128 ProteinModelPortal P04128 http://www.proteinmodelportal.org/query/uniprot/P04128 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2858471 http://www.ncbi.nlm.nih.gov/pubmed/2858471 PubMed 6147250 http://www.ncbi.nlm.nih.gov/pubmed/6147250 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418734 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418734 RefSeq WP_000695564 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000695564 SMR P04128 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P04128 STRING 511145.b4314 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4314&targetmode=cogs STRING COG3539 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3539&targetmode=cogs SUPFAM SSF49401 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49401 UniProtKB FIMA1_ECOLI http://www.uniprot.org/uniprot/FIMA1_ECOLI UniProtKB-AC P04128 http://www.uniprot.org/uniprot/P04128 charge swissprot:FIMA1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FIMA1_ECOLI eggNOG ENOG4108RQP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108RQP eggNOG ENOG4111KX6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111KX6 epestfind swissprot:FIMA1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FIMA1_ECOLI garnier swissprot:FIMA1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FIMA1_ECOLI helixturnhelix swissprot:FIMA1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FIMA1_ECOLI hmoment swissprot:FIMA1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FIMA1_ECOLI iep swissprot:FIMA1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FIMA1_ECOLI inforesidue swissprot:FIMA1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FIMA1_ECOLI octanol swissprot:FIMA1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FIMA1_ECOLI pepcoil swissprot:FIMA1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FIMA1_ECOLI pepdigest swissprot:FIMA1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FIMA1_ECOLI pepinfo swissprot:FIMA1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FIMA1_ECOLI pepnet swissprot:FIMA1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FIMA1_ECOLI pepstats swissprot:FIMA1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FIMA1_ECOLI pepwheel swissprot:FIMA1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FIMA1_ECOLI pepwindow swissprot:FIMA1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FIMA1_ECOLI sigcleave swissprot:FIMA1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FIMA1_ECOLI ## Database ID URL or Descriptions # BioGrid 4262276 143 # CATALYTIC ACTIVITY H(2)S + 3 NADP(+) + 3 H(2)O = sulfite + 3 NADPH. {ECO:0000255|HAMAP-Rule MF_01540}. # COFACTOR CYSI_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000255|HAMAP-Rule MF_01540, ECO 0000269|PubMed 7569952, ECO 0000269|PubMed 9315848}; Note=Binds 1 [4Fe-4S] cluster per subunit. {ECO 0000255|HAMAP- Rule MF_01540, ECO 0000269|PubMed 7569952, ECO 0000269|PubMed 9315848}; # COFACTOR CYSI_ECOLI Name=siroheme; Xref=ChEBI CHEBI 60052; Evidence={ECO 0000255|HAMAP-Rule MF_01540, ECO 0000269|PubMed 7569952, ECO 0000269|PubMed 9315848}; Note=Binds 1 siroheme per subunit. {ECO 0000255|HAMAP- Rule MF_01540, ECO 0000269|PubMed 7569952, ECO 0000269|PubMed 9315848}; # EcoGene EG10190 cysI # FUNCTION CYSI_ECOLI Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. {ECO 0000255|HAMAP-Rule MF_01540}. # GO_component GO:0009337 sulfite reductase complex (NADPH); IDA:EcoCyc. # GO_function GO:0004783 sulfite reductase (NADPH) activity; IEA:UniProtKB-HAMAP. # GO_function GO:0016002 sulfite reductase activity; IBA:GO_Central. # GO_function GO:0020037 heme binding; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0050311 sulfite reductase (ferredoxin) activity; IBA:GO_Central. # GO_function GO:0050661 NADP binding; IEA:InterPro. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IDA:EcoCyc. # GO_process GO:0000103 sulfate assimilation; IEA:UniProtKB-HAMAP. # GO_process GO:0008652 cellular amino acid biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0019344 cysteine biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0019419 sulfate reduction; IBA:GO_Central. # GO_process GO:0070814 hydrogen sulfide biosynthetic process; IEA:UniProtKB-HAMAP. # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.90.480.10 -; 2. # HAMAP MF_01540 CysI # IntAct P17846 10 # InterPro IPR005117 NiRdtase/SiRdtase_haem-b_fer # InterPro IPR006066 NO2/SO3_Rdtase_FeS/sirohaem_BS # InterPro IPR006067 NO2/SO3_Rdtase_4Fe4S_dom # InterPro IPR011786 CysI # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00920 Sulfur metabolism # Organism CYSI_ECOLI Escherichia coli (strain K12) # PATHWAY Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1. {ECO 0000255|HAMAP-Rule:MF_01540}. # PATRIC 32120938 VBIEscCol129921_2861 # PDB 1AOP X-ray; 1.60 A; A=74-570 # PDB 2AOP X-ray; 1.75 A; A=74-570 # PDB 2GEP X-ray; 1.90 A; A=74-570 # PDB 3AOP X-ray; 2.10 A; A=74-570 # PDB 3GEO X-ray; 2.10 A; A=74-570 # PDB 4AOP X-ray; 1.80 A; A=74-570 # PDB 4G38 X-ray; 1.56 A; A=1-570 # PDB 4G39 X-ray; 2.40 A; A=1-570 # PDB 4GEP X-ray; 2.00 A; A=74-570 # PDB 4HTR X-ray; 1.60 A; A=64-570 # PDB 5AOP X-ray; 2.20 A; A=74-570 # PDB 5GEP X-ray; 2.10 A; A=74-570 # PDB 6GEP X-ray; 1.80 A; A=74-570 # PDB 7GEP X-ray; 2.40 A; A=74-570 # PDB 8GEP X-ray; 2.20 A; A=74-570 # PIR G65057 RDECSH # PRINTS PR00397 SIROHAEM # PROSITE PS00365 NIR_SIR # Pfam PF01077 NIR_SIR; 2 # Pfam PF03460 NIR_SIR_ferr; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Sulfite reductase [NADPH] hemoprotein beta-component {ECO:0000255|HAMAP-Rule MF_01540} # RefSeq NP_417243 NC_000913.3 # RefSeq WP_001290679 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA23651.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA68816.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. {ECO 0000305}. # SUBUNIT Alpha(8)-beta(8). The alpha component is a flavoprotein, the beta component is a hemoprotein. {ECO:0000255|HAMAP- Rule MF_01540}. # SUPFAM SSF55124 SSF55124; 2 # TIGRFAMs TIGR02041 CysI # UniPathway UPA00140 UER00207 # eggNOG COG0155 LUCA # eggNOG ENOG4105ET1 Bacteria BLAST swissprot:CYSI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CYSI_ECOLI BioCyc ECOL316407:JW2733-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2733-MONOMER BioCyc EcoCyc:BETACOMP-MONOMER http://biocyc.org/getid?id=EcoCyc:BETACOMP-MONOMER BioCyc MetaCyc:BETACOMP-MONOMER http://biocyc.org/getid?id=MetaCyc:BETACOMP-MONOMER COG COG0155 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0155 DIP DIP-9380N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9380N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1007/BF00269864 http://dx.doi.org/10.1007/BF00269864 DOI 10.1021/bi971065q http://dx.doi.org/10.1021/bi971065q DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.270.5233.59 http://dx.doi.org/10.1126/science.270.5233.59 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.8.1.2 {ECO:0000255|HAMAP-Rule:MF_01540} http://www.genome.jp/dbget-bin/www_bget?EC:1.8.1.2 {ECO:0000255|HAMAP-Rule:MF_01540} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M23008 http://www.ebi.ac.uk/ena/data/view/M23008 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EMBL Y07525 http://www.ebi.ac.uk/ena/data/view/Y07525 ENZYME 1.8.1.2 {ECO:0000255|HAMAP-Rule:MF_01540} http://enzyme.expasy.org/EC/1.8.1.2 {ECO:0000255|HAMAP-Rule:MF_01540} EchoBASE EB0187 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0187 EcoGene EG10190 http://www.ecogene.org/geneInfo.php?eg_id=EG10190 EnsemblBacteria AAC75805 http://www.ensemblgenomes.org/id/AAC75805 EnsemblBacteria AAC75805 http://www.ensemblgenomes.org/id/AAC75805 EnsemblBacteria BAE76840 http://www.ensemblgenomes.org/id/BAE76840 EnsemblBacteria BAE76840 http://www.ensemblgenomes.org/id/BAE76840 EnsemblBacteria BAE76840 http://www.ensemblgenomes.org/id/BAE76840 EnsemblBacteria b2763 http://www.ensemblgenomes.org/id/b2763 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009337 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009337 GO_function GO:0004783 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004783 GO_function GO:0016002 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016002 GO_function GO:0020037 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0020037 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0050311 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050311 GO_function GO:0050661 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050661 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0000103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000103 GO_process GO:0008652 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008652 GO_process GO:0019344 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019344 GO_process GO:0019419 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019419 GO_process GO:0070814 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070814 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.90.480.10 http://www.cathdb.info/version/latest/superfamily/3.90.480.10 GeneID 947231 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947231 HAMAP MF_01540 http://hamap.expasy.org/unirule/MF_01540 HOGENOM HOG000218418 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218418&db=HOGENOM6 InParanoid P17846 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P17846 IntAct P17846 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P17846* IntEnz 1.8.1.2 {ECO:0000255|HAMAP-Rule:MF_01540} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.8.1.2 {ECO:0000255|HAMAP-Rule:MF_01540} InterPro IPR005117 http://www.ebi.ac.uk/interpro/entry/IPR005117 InterPro IPR006066 http://www.ebi.ac.uk/interpro/entry/IPR006066 InterPro IPR006067 http://www.ebi.ac.uk/interpro/entry/IPR006067 InterPro IPR011786 http://www.ebi.ac.uk/interpro/entry/IPR011786 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2733 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2733 KEGG_Gene eco:b2763 http://www.genome.jp/dbget-bin/www_bget?eco:b2763 KEGG_Orthology KO:K00381 http://www.genome.jp/dbget-bin/www_bget?KO:K00381 KEGG_Pathway ko00920 http://www.genome.jp/kegg-bin/show_pathway?ko00920 KEGG_Reaction rn:R00858 http://www.genome.jp/dbget-bin/www_bget?rn:R00858 OMA GKYNMYL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GKYNMYL PDB 1AOP http://www.ebi.ac.uk/pdbe-srv/view/entry/1AOP PDB 2AOP http://www.ebi.ac.uk/pdbe-srv/view/entry/2AOP PDB 2GEP http://www.ebi.ac.uk/pdbe-srv/view/entry/2GEP PDB 3AOP http://www.ebi.ac.uk/pdbe-srv/view/entry/3AOP PDB 3GEO http://www.ebi.ac.uk/pdbe-srv/view/entry/3GEO PDB 4AOP http://www.ebi.ac.uk/pdbe-srv/view/entry/4AOP PDB 4G38 http://www.ebi.ac.uk/pdbe-srv/view/entry/4G38 PDB 4G39 http://www.ebi.ac.uk/pdbe-srv/view/entry/4G39 PDB 4GEP http://www.ebi.ac.uk/pdbe-srv/view/entry/4GEP PDB 4HTR http://www.ebi.ac.uk/pdbe-srv/view/entry/4HTR PDB 5AOP http://www.ebi.ac.uk/pdbe-srv/view/entry/5AOP PDB 5GEP http://www.ebi.ac.uk/pdbe-srv/view/entry/5GEP PDB 6GEP http://www.ebi.ac.uk/pdbe-srv/view/entry/6GEP PDB 7GEP http://www.ebi.ac.uk/pdbe-srv/view/entry/7GEP PDB 8GEP http://www.ebi.ac.uk/pdbe-srv/view/entry/8GEP PDBsum 1AOP http://www.ebi.ac.uk/pdbsum/1AOP PDBsum 2AOP http://www.ebi.ac.uk/pdbsum/2AOP PDBsum 2GEP http://www.ebi.ac.uk/pdbsum/2GEP PDBsum 3AOP http://www.ebi.ac.uk/pdbsum/3AOP PDBsum 3GEO http://www.ebi.ac.uk/pdbsum/3GEO PDBsum 4AOP http://www.ebi.ac.uk/pdbsum/4AOP PDBsum 4G38 http://www.ebi.ac.uk/pdbsum/4G38 PDBsum 4G39 http://www.ebi.ac.uk/pdbsum/4G39 PDBsum 4GEP http://www.ebi.ac.uk/pdbsum/4GEP PDBsum 4HTR http://www.ebi.ac.uk/pdbsum/4HTR PDBsum 5AOP http://www.ebi.ac.uk/pdbsum/5AOP PDBsum 5GEP http://www.ebi.ac.uk/pdbsum/5GEP PDBsum 6GEP http://www.ebi.ac.uk/pdbsum/6GEP PDBsum 7GEP http://www.ebi.ac.uk/pdbsum/7GEP PDBsum 8GEP http://www.ebi.ac.uk/pdbsum/8GEP PRINTS PR00397 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00397 PROSITE PS00365 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00365 PSORT swissprot:CYSI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CYSI_ECOLI PSORT-B swissprot:CYSI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CYSI_ECOLI PSORT2 swissprot:CYSI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CYSI_ECOLI Pfam PF01077 http://pfam.xfam.org/family/PF01077 Pfam PF03460 http://pfam.xfam.org/family/PF03460 Phobius swissprot:CYSI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CYSI_ECOLI PhylomeDB P17846 http://phylomedb.org/?seqid=P17846 ProteinModelPortal P17846 http://www.proteinmodelportal.org/query/uniprot/P17846 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2005873 http://www.ncbi.nlm.nih.gov/pubmed/2005873 PubMed 2670946 http://www.ncbi.nlm.nih.gov/pubmed/2670946 PubMed 7569952 http://www.ncbi.nlm.nih.gov/pubmed/7569952 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9315848 http://www.ncbi.nlm.nih.gov/pubmed/9315848 RefSeq NP_417243 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417243 RefSeq WP_001290679 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001290679 SMR P17846 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P17846 STRING 511145.b2763 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2763&targetmode=cogs STRING COG0155 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0155&targetmode=cogs SUPFAM SSF55124 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55124 TIGRFAMs TIGR02041 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02041 UniProtKB CYSI_ECOLI http://www.uniprot.org/uniprot/CYSI_ECOLI UniProtKB-AC P17846 http://www.uniprot.org/uniprot/P17846 charge swissprot:CYSI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CYSI_ECOLI eggNOG COG0155 http://eggnogapi.embl.de/nog_data/html/tree/COG0155 eggNOG ENOG4105ET1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ET1 epestfind swissprot:CYSI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CYSI_ECOLI garnier swissprot:CYSI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CYSI_ECOLI helixturnhelix swissprot:CYSI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CYSI_ECOLI hmoment swissprot:CYSI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CYSI_ECOLI iep swissprot:CYSI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CYSI_ECOLI inforesidue swissprot:CYSI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CYSI_ECOLI octanol swissprot:CYSI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CYSI_ECOLI pepcoil swissprot:CYSI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CYSI_ECOLI pepdigest swissprot:CYSI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CYSI_ECOLI pepinfo swissprot:CYSI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CYSI_ECOLI pepnet swissprot:CYSI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CYSI_ECOLI pepstats swissprot:CYSI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CYSI_ECOLI pepwheel swissprot:CYSI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CYSI_ECOLI pepwindow swissprot:CYSI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CYSI_ECOLI sigcleave swissprot:CYSI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CYSI_ECOLI ## Database ID URL or Descriptions # BioGrid 4259468 319 # EcoGene EG12628 dppF # FUNCTION DPPF_ECOLI Part of the binding-protein-dependent transport system for dipeptides. Probably responsible for energy coupling to the transport system. # GO_component GO:0005737 cytoplasm; ISS:EcoCyc. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; ISS:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0015232 heme transporter activity; IMP:EcoliWiki. # GO_function GO:0016887 ATPase activity; IEA:InterPro. # GO_process GO:0015031 protein transport; IEA:UniProtKB-KW. # GO_process GO:0015833 peptide transport; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # Gene3D 3.40.50.300 -; 1. # IntAct P37313 15 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR013563 Oligopep_ABC_C # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00324 Dipeptide transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism DPPF_ECOLI Escherichia coli (strain K12) # PATRIC 32122548 VBIEscCol129921_3652 # PIR S47762 S47762 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # Pfam PF00005 ABC_tran # Pfam PF08352 oligo_HPY # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DPPF_ECOLI Dipeptide transport ATP-binding protein DppF # RefSeq NP_417997 NC_000913.3 # RefSeq WP_000107012 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA # SUBCELLULAR LOCATION DPPF_ECOLI Cell inner membrane {ECO 0000305}; Peripheral membrane protein {ECO 0000305}. # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR01727 oligo_HPY # eggNOG COG4608 LUCA # eggNOG ENOG4108JQ7 Bacteria BLAST swissprot:DPPF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DPPF_ECOLI BioCyc ECOL316407:JW3509-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3509-MONOMER BioCyc EcoCyc:DPPF-MONOMER http://biocyc.org/getid?id=EcoCyc:DPPF-MONOMER BioCyc MetaCyc:DPPF-MONOMER http://biocyc.org/getid?id=MetaCyc:DPPF-MONOMER COG COG1124 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1124 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1111/j.1365-2958.1994.tb01340.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb01340.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L08399 http://www.ebi.ac.uk/ena/data/view/L08399 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2512 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2512 EcoGene EG12628 http://www.ecogene.org/geneInfo.php?eg_id=EG12628 EnsemblBacteria AAC76565 http://www.ensemblgenomes.org/id/AAC76565 EnsemblBacteria AAC76565 http://www.ensemblgenomes.org/id/AAC76565 EnsemblBacteria BAE77754 http://www.ensemblgenomes.org/id/BAE77754 EnsemblBacteria BAE77754 http://www.ensemblgenomes.org/id/BAE77754 EnsemblBacteria BAE77754 http://www.ensemblgenomes.org/id/BAE77754 EnsemblBacteria b3540 http://www.ensemblgenomes.org/id/b3540 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0015232 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015232 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_process GO:0015031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031 GO_process GO:0015833 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015833 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948056 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948056 InParanoid P37313 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37313 IntAct P37313 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37313* InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR013563 http://www.ebi.ac.uk/interpro/entry/IPR013563 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3509 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3509 KEGG_Gene eco:b3540 http://www.genome.jp/dbget-bin/www_bget?eco:b3540 KEGG_Orthology KO:K12372 http://www.genome.jp/dbget-bin/www_bget?KO:K12372 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA IACFMVE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IACFMVE PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:DPPF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DPPF_ECOLI PSORT-B swissprot:DPPF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DPPF_ECOLI PSORT2 swissprot:DPPF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DPPF_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Pfam PF08352 http://pfam.xfam.org/family/PF08352 Phobius swissprot:DPPF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DPPF_ECOLI PhylomeDB P37313 http://phylomedb.org/?seqid=P37313 ProteinModelPortal P37313 http://www.proteinmodelportal.org/query/uniprot/P37313 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7536291 http://www.ncbi.nlm.nih.gov/pubmed/7536291 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417997 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417997 RefSeq WP_000107012 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000107012 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P37313 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37313 STRING 511145.b3540 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3540&targetmode=cogs STRING COG1124 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1124&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR01727 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01727 UniProtKB DPPF_ECOLI http://www.uniprot.org/uniprot/DPPF_ECOLI UniProtKB-AC P37313 http://www.uniprot.org/uniprot/P37313 charge swissprot:DPPF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DPPF_ECOLI eggNOG COG4608 http://eggnogapi.embl.de/nog_data/html/tree/COG4608 eggNOG ENOG4108JQ7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108JQ7 epestfind swissprot:DPPF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DPPF_ECOLI garnier swissprot:DPPF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DPPF_ECOLI helixturnhelix swissprot:DPPF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DPPF_ECOLI hmoment swissprot:DPPF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DPPF_ECOLI iep swissprot:DPPF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DPPF_ECOLI inforesidue swissprot:DPPF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DPPF_ECOLI octanol swissprot:DPPF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DPPF_ECOLI pepcoil swissprot:DPPF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DPPF_ECOLI pepdigest swissprot:DPPF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DPPF_ECOLI pepinfo swissprot:DPPF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DPPF_ECOLI pepnet swissprot:DPPF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DPPF_ECOLI pepstats swissprot:DPPF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DPPF_ECOLI pepwheel swissprot:DPPF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DPPF_ECOLI pepwindow swissprot:DPPF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DPPF_ECOLI sigcleave swissprot:DPPF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DPPF_ECOLI ## Database ID URL or Descriptions # Organism YUBN_ECOLI Escherichia coli (strain K12) # RecName YUBN_ECOLI Uncharacterized protein YubN # RefSeq NP_061446 NC_002483.1 # RefSeq WP_010892540 NC_002483.1 BLAST swissprot:YUBN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YUBN_ECOLI EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1263498 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263498 OMA ERHSQEN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ERHSQEN PSORT swissprot:YUBN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YUBN_ECOLI PSORT-B swissprot:YUBN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YUBN_ECOLI PSORT2 swissprot:YUBN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YUBN_ECOLI Phobius swissprot:YUBN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YUBN_ECOLI ProteinModelPortal Q9JMR2 http://www.proteinmodelportal.org/query/uniprot/Q9JMR2 RefSeq NP_061446 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061446 RefSeq WP_010892540 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_010892540 UniProtKB YUBN_ECOLI http://www.uniprot.org/uniprot/YUBN_ECOLI UniProtKB-AC Q9JMR2 http://www.uniprot.org/uniprot/Q9JMR2 charge swissprot:YUBN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YUBN_ECOLI epestfind swissprot:YUBN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YUBN_ECOLI garnier swissprot:YUBN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YUBN_ECOLI helixturnhelix swissprot:YUBN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YUBN_ECOLI hmoment swissprot:YUBN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YUBN_ECOLI iep swissprot:YUBN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YUBN_ECOLI inforesidue swissprot:YUBN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YUBN_ECOLI octanol swissprot:YUBN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YUBN_ECOLI pepcoil swissprot:YUBN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YUBN_ECOLI pepdigest swissprot:YUBN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YUBN_ECOLI pepinfo swissprot:YUBN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YUBN_ECOLI pepnet swissprot:YUBN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YUBN_ECOLI pepstats swissprot:YUBN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YUBN_ECOLI pepwheel swissprot:YUBN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YUBN_ECOLI pepwindow swissprot:YUBN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YUBN_ECOLI sigcleave swissprot:YUBN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YUBN_ECOLI ## Database ID URL or Descriptions # AltName HYPF_ECOLI Carbamoyl phosphate-converting enzyme HypF # AltName HYPF_ECOLI [NiFe]-hydrogenase maturation factor HypF # BioGrid 4259427 14 # DOMAIN HYPF_ECOLI Contains a unique C-terminal domain with an O- carbamoyltransferase motif. # DOMAIN HYPF_ECOLI Contains a version of the YrdC-like domain which probably has a different function than that of some proteins where it has been implicated in RNA binding. # EcoGene EG11551 hypF # FUNCTION HYPF_ECOLI Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide. {ECO 0000269|PubMed 12377778, ECO 0000269|PubMed 15291820, ECO 0000269|PubMed 15504408, ECO 0000269|PubMed 8661925}. # GO_function GO:0003725 double-stranded RNA binding; IEA:InterPro. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_function GO:0016743 carboxyl- or carbamoyltransferase activity; IDA:EcoCyc. # GO_process GO:0046944 protein carbamoylation; IDA:EcoCyc. # GO_process GO:0051604 protein maturation; IDA:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0051604 protein maturation # Gene3D 3.90.870.10 -; 1. # IntAct P30131 8 # InterPro IPR001792 Acylphosphatase-like_dom # InterPro IPR004421 Carbamoyltransferase_HypF # InterPro IPR006070 YrdC-like_dom # InterPro IPR011125 Znf_HypF # InterPro IPR017945 DHBP_synth_RibB-like_a/b_dom # InterPro IPR017968 Acylphosphatase_CS # Organism HYPF_ECOLI Escherichia coli (strain K12) # PATHWAY HYPF_ECOLI Protein modification; [NiFe] hydrogenase maturation. # PATRIC 32120822 VBIEscCol129921_2803 # PDB 1GXT X-ray; 1.30 A; A=1-91 # PDB 1GXU X-ray; 1.27 A; A=1-91 # PIR D65051 D65051 # PIRSF PIRSF006256 CMPcnvr_hdrg_mat # PROSITE PS00150 ACYLPHOSPHATASE_1 # PROSITE PS51160 ACYLPHOSPHATASE_3 # PROSITE PS51163 YRDC # Pfam PF00708 Acylphosphatase # Pfam PF01300 Sua5_yciO_yrdC # Pfam PF07503 zf-HYPF; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HYPF_ECOLI Carbamoyltransferase HypF # RefSeq NP_417192 NC_000913.3 # RefSeq WP_001107704 NZ_LN832404.1 # SIMILARITY Belongs to the carbamoyltransferase HypF family. {ECO 0000305}. # SIMILARITY Contains 1 YrdC-like domain. {ECO:0000255|PROSITE- ProRule PRU00518}. # SIMILARITY Contains 1 acylphosphatase-like domain. {ECO:0000255|PROSITE-ProRule PRU00520}. # SUBUNIT Forms a complex with HypE. {ECO:0000269|PubMed 12206761}. # SUPFAM SSF54975 SSF54975 # SUPFAM SSF55821 SSF55821 # TIGRFAMs TIGR00143 hypF # eggNOG COG0068 LUCA # eggNOG ENOG4105C8H Bacteria BLAST swissprot:HYPF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HYPF_ECOLI BioCyc ECOL316407:JW5433-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5433-MONOMER BioCyc EcoCyc:EG11551-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11551-MONOMER BioCyc MetaCyc:EG11551-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11551-MONOMER COG COG0068 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0068 DIP DIP-10000N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10000N DOI 10.1007/s002030050335 http://dx.doi.org/10.1007/s002030050335 DOI 10.1016/S0022-2836(02)00713-1 http://dx.doi.org/10.1016/S0022-2836(02)00713-1 DOI 10.1016/j.jmb.2004.09.040 http://dx.doi.org/10.1016/j.jmb.2004.09.040 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M204601200 http://dx.doi.org/10.1074/jbc.M204601200 DOI 10.1111/j.1432-1033.2004.04280.x http://dx.doi.org/10.1111/j.1432-1033.2004.04280.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.3.- http://www.genome.jp/dbget-bin/www_bget?EC:2.1.3.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D14422 http://www.ebi.ac.uk/ena/data/view/D14422 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 ENZYME 2.1.3.- http://enzyme.expasy.org/EC/2.1.3.- EchoBASE EB1512 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1512 EcoGene EG11551 http://www.ecogene.org/geneInfo.php?eg_id=EG11551 EnsemblBacteria AAC75754 http://www.ensemblgenomes.org/id/AAC75754 EnsemblBacteria AAC75754 http://www.ensemblgenomes.org/id/AAC75754 EnsemblBacteria BAE76789 http://www.ensemblgenomes.org/id/BAE76789 EnsemblBacteria BAE76789 http://www.ensemblgenomes.org/id/BAE76789 EnsemblBacteria BAE76789 http://www.ensemblgenomes.org/id/BAE76789 EnsemblBacteria b2712 http://www.ensemblgenomes.org/id/b2712 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003725 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003725 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0016743 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016743 GO_process GO:0046944 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046944 GO_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 Gene3D 3.90.870.10 http://www.cathdb.info/version/latest/superfamily/3.90.870.10 GeneID 944963 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944963 HOGENOM HOG000278743 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278743&db=HOGENOM6 InParanoid P30131 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30131 IntAct P30131 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P30131* IntEnz 2.1.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.3 InterPro IPR001792 http://www.ebi.ac.uk/interpro/entry/IPR001792 InterPro IPR004421 http://www.ebi.ac.uk/interpro/entry/IPR004421 InterPro IPR006070 http://www.ebi.ac.uk/interpro/entry/IPR006070 InterPro IPR011125 http://www.ebi.ac.uk/interpro/entry/IPR011125 InterPro IPR017945 http://www.ebi.ac.uk/interpro/entry/IPR017945 InterPro IPR017968 http://www.ebi.ac.uk/interpro/entry/IPR017968 KEGG_Gene ecj:JW5433 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5433 KEGG_Gene eco:b2712 http://www.genome.jp/dbget-bin/www_bget?eco:b2712 KEGG_Orthology KO:K04656 http://www.genome.jp/dbget-bin/www_bget?KO:K04656 MINT MINT-1276849 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1276849 OMA YVMTSAN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YVMTSAN PDB 1GXT http://www.ebi.ac.uk/pdbe-srv/view/entry/1GXT PDB 1GXU http://www.ebi.ac.uk/pdbe-srv/view/entry/1GXU PDBsum 1GXT http://www.ebi.ac.uk/pdbsum/1GXT PDBsum 1GXU http://www.ebi.ac.uk/pdbsum/1GXU PROSITE PS00150 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00150 PROSITE PS51160 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51160 PROSITE PS51163 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51163 PSORT swissprot:HYPF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HYPF_ECOLI PSORT-B swissprot:HYPF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HYPF_ECOLI PSORT2 swissprot:HYPF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HYPF_ECOLI Pfam PF00708 http://pfam.xfam.org/family/PF00708 Pfam PF01300 http://pfam.xfam.org/family/PF01300 Pfam PF07503 http://pfam.xfam.org/family/PF07503 Phobius swissprot:HYPF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HYPF_ECOLI PhylomeDB P30131 http://phylomedb.org/?seqid=P30131 ProteinModelPortal P30131 http://www.proteinmodelportal.org/query/uniprot/P30131 PubMed 12206761 http://www.ncbi.nlm.nih.gov/pubmed/12206761 PubMed 12377778 http://www.ncbi.nlm.nih.gov/pubmed/12377778 PubMed 15291820 http://www.ncbi.nlm.nih.gov/pubmed/15291820 PubMed 15504408 http://www.ncbi.nlm.nih.gov/pubmed/15504408 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8661925 http://www.ncbi.nlm.nih.gov/pubmed/8661925 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417192 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417192 RefSeq WP_001107704 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001107704 SMR P30131 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P30131 STRING 511145.b2712 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2712&targetmode=cogs STRING COG0068 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0068&targetmode=cogs SUPFAM SSF54975 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54975 SUPFAM SSF55821 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55821 TIGRFAMs TIGR00143 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00143 UniProtKB HYPF_ECOLI http://www.uniprot.org/uniprot/HYPF_ECOLI UniProtKB-AC P30131 http://www.uniprot.org/uniprot/P30131 charge swissprot:HYPF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HYPF_ECOLI eggNOG COG0068 http://eggnogapi.embl.de/nog_data/html/tree/COG0068 eggNOG ENOG4105C8H http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C8H epestfind swissprot:HYPF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HYPF_ECOLI garnier swissprot:HYPF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HYPF_ECOLI helixturnhelix swissprot:HYPF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HYPF_ECOLI hmoment swissprot:HYPF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HYPF_ECOLI iep swissprot:HYPF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HYPF_ECOLI inforesidue swissprot:HYPF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HYPF_ECOLI octanol swissprot:HYPF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HYPF_ECOLI pepcoil swissprot:HYPF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HYPF_ECOLI pepdigest swissprot:HYPF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HYPF_ECOLI pepinfo swissprot:HYPF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HYPF_ECOLI pepnet swissprot:HYPF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HYPF_ECOLI pepstats swissprot:HYPF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HYPF_ECOLI pepwheel swissprot:HYPF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HYPF_ECOLI pepwindow swissprot:HYPF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HYPF_ECOLI sigcleave swissprot:HYPF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HYPF_ECOLI ## Database ID URL or Descriptions # BioGrid 4263389 9 # EcoGene EG12508 ytfH # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # InterPro IPR002577 HTH_HxlR # InterPro IPR011991 WHTH_DNA-bd_dom # Organism YTFH_ECOLI Escherichia coli (strain K12) # PATRIC 32123999 VBIEscCol129921_4344 # PIR S56437 S56437 # PROSITE PS51118 HTH_HXLR # Pfam PF01638 HxlR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YTFH_ECOLI Uncharacterized HTH-type transcriptional regulator YtfH # RefSeq NP_418633 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA97108.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Contains 1 HTH hxlR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00435}. # SUPFAM SSF46785 SSF46785 # eggNOG COG1733 LUCA # eggNOG ENOG4105KVH Bacteria BLAST swissprot:YTFH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YTFH_ECOLI BioCyc ECOL316407:JW5747-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5747-MONOMER BioCyc EcoCyc:G7869-MONOMER http://biocyc.org/getid?id=EcoCyc:G7869-MONOMER DIP DIP-12936N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12936N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2401 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2401 EcoGene EG12508 http://www.ecogene.org/geneInfo.php?eg_id=EG12508 EnsemblBacteria AAC77169 http://www.ensemblgenomes.org/id/AAC77169 EnsemblBacteria AAC77169 http://www.ensemblgenomes.org/id/AAC77169 EnsemblBacteria BAE78213 http://www.ensemblgenomes.org/id/BAE78213 EnsemblBacteria BAE78213 http://www.ensemblgenomes.org/id/BAE78213 EnsemblBacteria BAE78213 http://www.ensemblgenomes.org/id/BAE78213 EnsemblBacteria b4212 http://www.ensemblgenomes.org/id/b4212 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 948730 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948730 HOGENOM HOG000293549 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000293549&db=HOGENOM6 InParanoid P0ACN2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACN2 InterPro IPR002577 http://www.ebi.ac.uk/interpro/entry/IPR002577 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW5747 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5747 KEGG_Gene eco:b4212 http://www.genome.jp/dbget-bin/www_bget?eco:b4212 OMA HVCSRWG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HVCSRWG PROSITE PS51118 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51118 PSORT swissprot:YTFH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YTFH_ECOLI PSORT-B swissprot:YTFH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YTFH_ECOLI PSORT2 swissprot:YTFH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YTFH_ECOLI Pfam PF01638 http://pfam.xfam.org/family/PF01638 Phobius swissprot:YTFH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YTFH_ECOLI PhylomeDB P0ACN2 http://phylomedb.org/?seqid=P0ACN2 ProteinModelPortal P0ACN2 http://www.proteinmodelportal.org/query/uniprot/P0ACN2 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418633 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418633 SMR P0ACN2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACN2 STRING 511145.b4212 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4212&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB YTFH_ECOLI http://www.uniprot.org/uniprot/YTFH_ECOLI UniProtKB-AC P0ACN2 http://www.uniprot.org/uniprot/P0ACN2 charge swissprot:YTFH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YTFH_ECOLI eggNOG COG1733 http://eggnogapi.embl.de/nog_data/html/tree/COG1733 eggNOG ENOG4105KVH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KVH epestfind swissprot:YTFH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YTFH_ECOLI garnier swissprot:YTFH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YTFH_ECOLI helixturnhelix swissprot:YTFH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YTFH_ECOLI hmoment swissprot:YTFH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YTFH_ECOLI iep swissprot:YTFH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YTFH_ECOLI inforesidue swissprot:YTFH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YTFH_ECOLI octanol swissprot:YTFH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YTFH_ECOLI pepcoil swissprot:YTFH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YTFH_ECOLI pepdigest swissprot:YTFH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YTFH_ECOLI pepinfo swissprot:YTFH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YTFH_ECOLI pepnet swissprot:YTFH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YTFH_ECOLI pepstats swissprot:YTFH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YTFH_ECOLI pepwheel swissprot:YTFH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YTFH_ECOLI pepwindow swissprot:YTFH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YTFH_ECOLI sigcleave swissprot:YTFH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YTFH_ECOLI ## Database ID URL or Descriptions # BioGrid 4260587 208 # EcoGene EG14208 bamB # FUNCTION BAMB_ECOLI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Nonessential member of the complex, which may orient the flexible periplasmic domain of BamA for interaction with other Bam components, chaperones and nascent outer membrane proteins. {ECO 0000255|HAMAP-Rule MF_00923, ECO 0000269|PubMed 20378773, ECO 0000269|PubMed 21277859, ECO 0000269|PubMed 21586578, ECO 0000269|PubMed 21823654}. # GO_component GO:1990063 Bam protein complex; IDA:EcoCyc. # GO_function GO:0016491 oxidoreductase activity; IBA:GO_Central. # GO_process GO:0043165 Gram-negative-bacterium-type cell outer membrane assembly; IDA:EcoCyc. # GO_process GO:0051205 protein insertion into membrane; IDA:EcoCyc. # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0061024 membrane organization # Gene3D 2.140.10.10 -; 1. # HAMAP MF_00923 OM_assembly_BamB # INTERACTION BAMB_ECOLI Self; NbExp=2; IntAct=EBI-907297, EBI-907297; P0A940 bamA; NbExp=16; IntAct=EBI-907297, EBI-907371; P0ABZ6 surA; NbExp=2; IntAct=EBI-907297, EBI-558651; # IntAct P77774 8 # InterPro IPR002372 PQQ_repeat # InterPro IPR011047 Quinoprotein_ADH-like_supfam # InterPro IPR017687 BamB # InterPro IPR018391 PQQ_beta_propeller_repeat # InterPro IPR027295 Quinoprotein_ADH-like_fam # Organism BAMB_ECOLI Escherichia coli (strain K12) # PATRIC 32120417 VBIEscCol129921_2611 # PDB 2YH3 X-ray; 2.60 A; A=22-392 # PDB 2YMS X-ray; 2.10 A; A=62-191, B=113-186, C=248-322, D=247-320 # PDB 3P1L X-ray; 2.60 A; A=21-392 # PDB 3PRW X-ray; 1.80 A; A=21-392 # PDB 3Q7M X-ray; 1.65 A; A=21-392 # PDB 3Q7N X-ray; 1.77 A; A=21-392 # PDB 3Q7O X-ray; 2.09 A; A=21-392 # PDB 4PK1 X-ray; 3.10 A; A=21-392 # PDB 4XGA X-ray; 2.15 A; A=20-392 # PDB 5AYW X-ray; 3.56 A; B=20-392 # PDB 5D0O X-ray; 2.90 A; B=1-392 # PDB 5LJO EM; 4.90 A; B=22-392 # PIR G65027 G65027 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF13360 PQQ_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Outer membrane protein assembly factor BamB {ECO:0000255|HAMAP-Rule MF_00923} # RefSeq NP_417007 NC_000913.3 # RefSeq WP_001177052 NZ_LN832404.1 # SIMILARITY Belongs to the BamB family. {ECO:0000255|HAMAP- Rule MF_00923}. # SMART SM00564 PQQ; 7 # SUBCELLULAR LOCATION BAMB_ECOLI Cell outer membrane {ECO 0000255|HAMAP- Rule MF_00923, ECO 0000269|PubMed 15851030}; Lipid-anchor {ECO 0000255|HAMAP-Rule MF_00923, ECO 0000269|PubMed 15851030}. # SUBUNIT BAMB_ECOLI Part of the Bam complex, which is composed of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE. Monomer. Interacts directly with BamA. {ECO 0000255|HAMAP- Rule MF_00923, ECO 0000269|PubMed 15851030, ECO 0000269|PubMed 16824102, ECO 0000269|PubMed 20378773, ECO 0000269|PubMed 21277859, ECO 0000269|PubMed 21586578, ECO 0000269|PubMed 21823654}. # SUPFAM SSF50998 SSF50998 # TCDB 1.B.33.1 the outer membrane protein insertion porin (bam complex) (ompip) family # TIGRFAMs TIGR03300 assembly_YfgL # eggNOG COG1520 LUCA # eggNOG ENOG4105CNE Bacteria BLAST swissprot:BAMB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BAMB_ECOLI BioCyc ECOL316407:JW2496-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2496-MONOMER BioCyc EcoCyc:G7320-MONOMER http://biocyc.org/getid?id=EcoCyc:G7320-MONOMER DIP DIP-12042N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12042N DOI 10.1016/j.cell.2005.02.015 http://dx.doi.org/10.1016/j.cell.2005.02.015 DOI 10.1016/j.jmb.2010.12.020 http://dx.doi.org/10.1016/j.jmb.2010.12.020 DOI 10.1016/j.jmb.2011.01.042 http://dx.doi.org/10.1016/j.jmb.2011.01.042 DOI 10.1021/bi2010784 http://dx.doi.org/10.1021/bi2010784 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M111.238931 http://dx.doi.org/10.1074/jbc.M111.238931 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1365-2958.2006.05211.x http://dx.doi.org/10.1111/j.1365-2958.2006.05211.x DOI 10.1126/science.1188919 http://dx.doi.org/10.1126/science.1188919 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3960 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3960 EcoGene EG14208 http://www.ecogene.org/geneInfo.php?eg_id=EG14208 EnsemblBacteria AAC75565 http://www.ensemblgenomes.org/id/AAC75565 EnsemblBacteria AAC75565 http://www.ensemblgenomes.org/id/AAC75565 EnsemblBacteria BAA16398 http://www.ensemblgenomes.org/id/BAA16398 EnsemblBacteria BAA16398 http://www.ensemblgenomes.org/id/BAA16398 EnsemblBacteria BAA16398 http://www.ensemblgenomes.org/id/BAA16398 EnsemblBacteria b2512 http://www.ensemblgenomes.org/id/b2512 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:1990063 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990063 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_process GO:0043165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043165 GO_process GO:0051205 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051205 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0061024 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024 Gene3D 2.140.10.10 http://www.cathdb.info/version/latest/superfamily/2.140.10.10 GeneID 946982 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946982 HAMAP MF_00923 http://hamap.expasy.org/unirule/MF_00923 HOGENOM HOG000260994 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260994&db=HOGENOM6 InParanoid P77774 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77774 IntAct P77774 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77774* InterPro IPR002372 http://www.ebi.ac.uk/interpro/entry/IPR002372 InterPro IPR011047 http://www.ebi.ac.uk/interpro/entry/IPR011047 InterPro IPR017687 http://www.ebi.ac.uk/interpro/entry/IPR017687 InterPro IPR018391 http://www.ebi.ac.uk/interpro/entry/IPR018391 InterPro IPR027295 http://www.ebi.ac.uk/interpro/entry/IPR027295 KEGG_Gene ecj:JW2496 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2496 KEGG_Gene eco:b2512 http://www.genome.jp/dbget-bin/www_bget?eco:b2512 OMA FTPTKVW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FTPTKVW PDB 2YH3 http://www.ebi.ac.uk/pdbe-srv/view/entry/2YH3 PDB 2YMS http://www.ebi.ac.uk/pdbe-srv/view/entry/2YMS PDB 3P1L http://www.ebi.ac.uk/pdbe-srv/view/entry/3P1L PDB 3PRW http://www.ebi.ac.uk/pdbe-srv/view/entry/3PRW PDB 3Q7M http://www.ebi.ac.uk/pdbe-srv/view/entry/3Q7M PDB 3Q7N http://www.ebi.ac.uk/pdbe-srv/view/entry/3Q7N PDB 3Q7O http://www.ebi.ac.uk/pdbe-srv/view/entry/3Q7O PDB 4PK1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4PK1 PDB 4XGA http://www.ebi.ac.uk/pdbe-srv/view/entry/4XGA PDB 5AYW http://www.ebi.ac.uk/pdbe-srv/view/entry/5AYW PDB 5D0O http://www.ebi.ac.uk/pdbe-srv/view/entry/5D0O PDB 5LJO http://www.ebi.ac.uk/pdbe-srv/view/entry/5LJO PDBsum 2YH3 http://www.ebi.ac.uk/pdbsum/2YH3 PDBsum 2YMS http://www.ebi.ac.uk/pdbsum/2YMS PDBsum 3P1L http://www.ebi.ac.uk/pdbsum/3P1L PDBsum 3PRW http://www.ebi.ac.uk/pdbsum/3PRW PDBsum 3Q7M http://www.ebi.ac.uk/pdbsum/3Q7M PDBsum 3Q7N http://www.ebi.ac.uk/pdbsum/3Q7N PDBsum 3Q7O http://www.ebi.ac.uk/pdbsum/3Q7O PDBsum 4PK1 http://www.ebi.ac.uk/pdbsum/4PK1 PDBsum 4XGA http://www.ebi.ac.uk/pdbsum/4XGA PDBsum 5AYW http://www.ebi.ac.uk/pdbsum/5AYW PDBsum 5D0O http://www.ebi.ac.uk/pdbsum/5D0O PDBsum 5LJO http://www.ebi.ac.uk/pdbsum/5LJO PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:BAMB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BAMB_ECOLI PSORT-B swissprot:BAMB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BAMB_ECOLI PSORT2 swissprot:BAMB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BAMB_ECOLI Pfam PF13360 http://pfam.xfam.org/family/PF13360 Phobius swissprot:BAMB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BAMB_ECOLI PhylomeDB P77774 http://phylomedb.org/?seqid=P77774 ProteinModelPortal P77774 http://www.proteinmodelportal.org/query/uniprot/P77774 PubMed 15851030 http://www.ncbi.nlm.nih.gov/pubmed/15851030 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16824102 http://www.ncbi.nlm.nih.gov/pubmed/16824102 PubMed 20378773 http://www.ncbi.nlm.nih.gov/pubmed/20378773 PubMed 21168416 http://www.ncbi.nlm.nih.gov/pubmed/21168416 PubMed 21277859 http://www.ncbi.nlm.nih.gov/pubmed/21277859 PubMed 21586578 http://www.ncbi.nlm.nih.gov/pubmed/21586578 PubMed 21823654 http://www.ncbi.nlm.nih.gov/pubmed/21823654 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417007 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417007 RefSeq WP_001177052 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001177052 SMART SM00564 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00564 SMR P77774 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77774 STRING 511145.b2512 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2512&targetmode=cogs SUPFAM SSF50998 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50998 TCDB 1.B.33.1 http://www.tcdb.org/search/result.php?tc=1.B.33.1 TIGRFAMs TIGR03300 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03300 UniProtKB BAMB_ECOLI http://www.uniprot.org/uniprot/BAMB_ECOLI UniProtKB-AC P77774 http://www.uniprot.org/uniprot/P77774 charge swissprot:BAMB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BAMB_ECOLI eggNOG COG1520 http://eggnogapi.embl.de/nog_data/html/tree/COG1520 eggNOG ENOG4105CNE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CNE epestfind swissprot:BAMB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BAMB_ECOLI garnier swissprot:BAMB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BAMB_ECOLI helixturnhelix swissprot:BAMB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BAMB_ECOLI hmoment swissprot:BAMB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BAMB_ECOLI iep swissprot:BAMB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BAMB_ECOLI inforesidue swissprot:BAMB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BAMB_ECOLI octanol swissprot:BAMB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BAMB_ECOLI pepcoil swissprot:BAMB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BAMB_ECOLI pepdigest swissprot:BAMB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BAMB_ECOLI pepinfo swissprot:BAMB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BAMB_ECOLI pepnet swissprot:BAMB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BAMB_ECOLI pepstats swissprot:BAMB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BAMB_ECOLI pepwheel swissprot:BAMB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BAMB_ECOLI pepwindow swissprot:BAMB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BAMB_ECOLI sigcleave swissprot:BAMB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BAMB_ECOLI ## Database ID URL or Descriptions # BioGrid 4262367 16 # EcoGene EG12996 glcE # GO_function GO:0019154 glycolate dehydrogenase activity; IMP:EcoCyc. # GO_function GO:0050660 flavin adenine dinucleotide binding; IEA:InterPro. # GO_process GO:0046296 glycolate catabolic process; IMP:EcoCyc. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.45.10 -; 1. # Gene3D 3.30.465.10 -; 1. # InterPro IPR006094 Oxid_FAD_bind_N # InterPro IPR016164 FAD-linked_Oxase-like_C # InterPro IPR016166 FAD-bd_2 # InterPro IPR016169 CO_DH_flavot_FAD-bd_sub2 # InterPro IPR016171 Vanillyl_alc_oxidase_C-sub2 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Pathway ko00630 Glyoxylate and dicarboxylate metabolism # Organism GLCE_ECOLI Escherichia coli (strain K12) # PATRIC 32121372 VBIEscCol129921_3073 # PROSITE PS51387 FAD_PCMH # Pfam PF01565 FAD_binding_4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLCE_ECOLI Glycolate oxidase subunit GlcE # RefSeq WP_000943100 NZ_LN832404.1 # RefSeq YP_026191 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA69145.1; Type=Frameshift; Positions=319; Note=Fuses together glcE and glcF.; Evidence={ECO 0000305}; # SIMILARITY Contains 1 FAD-binding PCMH-type domain. {ECO:0000255|PROSITE-ProRule PRU00718}. # SUPFAM SSF55103 SSF55103 # SUPFAM SSF56176 SSF56176 # eggNOG COG0277 LUCA # eggNOG ENOG4105EU8 Bacteria BLAST swissprot:GLCE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLCE_ECOLI BioCyc ECOL316407:JW5487-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5487-MONOMER BioCyc EcoCyc:G7544-MONOMER http://biocyc.org/getid?id=EcoCyc:G7544-MONOMER BioCyc MetaCyc:G7544-MONOMER http://biocyc.org/getid?id=MetaCyc:G7544-MONOMER COG COG0277 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0277 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L43490 http://www.ebi.ac.uk/ena/data/view/L43490 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2819 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2819 EcoGene EG12996 http://www.ecogene.org/geneInfo.php?eg_id=EG12996 EnsemblBacteria AAT48158 http://www.ensemblgenomes.org/id/AAT48158 EnsemblBacteria AAT48158 http://www.ensemblgenomes.org/id/AAT48158 EnsemblBacteria BAE77039 http://www.ensemblgenomes.org/id/BAE77039 EnsemblBacteria BAE77039 http://www.ensemblgenomes.org/id/BAE77039 EnsemblBacteria BAE77039 http://www.ensemblgenomes.org/id/BAE77039 EnsemblBacteria b4468 http://www.ensemblgenomes.org/id/b4468 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0019154 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019154 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_process GO:0046296 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046296 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.45.10 http://www.cathdb.info/version/latest/superfamily/1.10.45.10 Gene3D 3.30.465.10 http://www.cathdb.info/version/latest/superfamily/3.30.465.10 GeneID 2847718 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2847718 HOGENOM HOG000230994 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230994&db=HOGENOM6 InParanoid P52073 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P52073 InterPro IPR006094 http://www.ebi.ac.uk/interpro/entry/IPR006094 InterPro IPR016164 http://www.ebi.ac.uk/interpro/entry/IPR016164 InterPro IPR016166 http://www.ebi.ac.uk/interpro/entry/IPR016166 InterPro IPR016169 http://www.ebi.ac.uk/interpro/entry/IPR016169 InterPro IPR016171 http://www.ebi.ac.uk/interpro/entry/IPR016171 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Gene ecj:JW5487 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5487 KEGG_Gene eco:b4468 http://www.genome.jp/dbget-bin/www_bget?eco:b4468 KEGG_Orthology KO:K11472 http://www.genome.jp/dbget-bin/www_bget?KO:K11472 KEGG_Pathway ko00630 http://www.genome.jp/kegg-bin/show_pathway?ko00630 KEGG_Reaction rn:R00475 http://www.genome.jp/dbget-bin/www_bget?rn:R00475 OMA FLRIEGF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FLRIEGF PROSITE PS51387 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51387 PSORT swissprot:GLCE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLCE_ECOLI PSORT-B swissprot:GLCE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLCE_ECOLI PSORT2 swissprot:GLCE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLCE_ECOLI Pfam PF01565 http://pfam.xfam.org/family/PF01565 Phobius swissprot:GLCE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLCE_ECOLI PhylomeDB P52073 http://phylomedb.org/?seqid=P52073 ProteinModelPortal P52073 http://www.proteinmodelportal.org/query/uniprot/P52073 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8606183 http://www.ncbi.nlm.nih.gov/pubmed/8606183 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000943100 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000943100 RefSeq YP_026191 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026191 SMR P52073 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P52073 STRING 511145.b4468 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4468&targetmode=cogs STRING COG0277 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0277&targetmode=cogs SUPFAM SSF55103 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55103 SUPFAM SSF56176 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56176 UniProtKB GLCE_ECOLI http://www.uniprot.org/uniprot/GLCE_ECOLI UniProtKB-AC P52073 http://www.uniprot.org/uniprot/P52073 charge swissprot:GLCE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLCE_ECOLI eggNOG COG0277 http://eggnogapi.embl.de/nog_data/html/tree/COG0277 eggNOG ENOG4105EU8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EU8 epestfind swissprot:GLCE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLCE_ECOLI garnier swissprot:GLCE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLCE_ECOLI helixturnhelix swissprot:GLCE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLCE_ECOLI hmoment swissprot:GLCE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLCE_ECOLI iep swissprot:GLCE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLCE_ECOLI inforesidue swissprot:GLCE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLCE_ECOLI octanol swissprot:GLCE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLCE_ECOLI pepcoil swissprot:GLCE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLCE_ECOLI pepdigest swissprot:GLCE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLCE_ECOLI pepinfo swissprot:GLCE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLCE_ECOLI pepnet swissprot:GLCE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLCE_ECOLI pepstats swissprot:GLCE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLCE_ECOLI pepwheel swissprot:GLCE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLCE_ECOLI pepwindow swissprot:GLCE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLCE_ECOLI sigcleave swissprot:GLCE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLCE_ECOLI ## Database ID URL or Descriptions # BioGrid 4263232 8 # CDD cd06261 TM_PBP2 # EcoGene EG13912 ycjO # FUNCTION YCJO_ECOLI Probably part of the binding-protein-dependent transport system YcjNOP. Probably responsible for the translocation of the substrate across the membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006810 transport; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006810 transport # Gene3D 1.10.3720.10 -; 1. # InterPro IPR000515 MetI-like # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00207 Putative multiple sugar transport system # KEGG_Brite ko02000 Transporters # Organism YCJO_ECOLI Escherichia coli (strain K12) # PATRIC 32117894 VBIEscCol129921_1367 # PIR B64880 B64880 # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCJO_ECOLI Inner membrane ABC transporter permease protein YcjO # RefSeq NP_415827 NC_000913.3 # RefSeq WP_001080790 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION YCJO_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF161098 SSF161098 # TCDB 3.A.1.1.46 the atp-binding cassette (abc) superfamily # eggNOG COG1175 LUCA # eggNOG ENOG4105HS6 Bacteria BLAST swissprot:YCJO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCJO_ECOLI BioCyc ECOL316407:JW1304-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1304-MONOMER BioCyc EcoCyc:YCJO-MONOMER http://biocyc.org/getid?id=EcoCyc:YCJO-MONOMER COG COG1175 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1175 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3671 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3671 EcoGene EG13912 http://www.ecogene.org/geneInfo.php?eg_id=EG13912 EnsemblBacteria AAC74393 http://www.ensemblgenomes.org/id/AAC74393 EnsemblBacteria AAC74393 http://www.ensemblgenomes.org/id/AAC74393 EnsemblBacteria BAA14887 http://www.ensemblgenomes.org/id/BAA14887 EnsemblBacteria BAA14887 http://www.ensemblgenomes.org/id/BAA14887 EnsemblBacteria BAA14887 http://www.ensemblgenomes.org/id/BAA14887 EnsemblBacteria b1311 http://www.ensemblgenomes.org/id/b1311 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 945888 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945888 HOGENOM HOG000220407 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220407&db=HOGENOM6 InParanoid P0AFR7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFR7 InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1304 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1304 KEGG_Gene eco:b1311 http://www.genome.jp/dbget-bin/www_bget?eco:b1311 KEGG_Orthology KO:K02025 http://www.genome.jp/dbget-bin/www_bget?KO:K02025 OMA PLFLGVW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PLFLGVW PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:YCJO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCJO_ECOLI PSORT-B swissprot:YCJO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCJO_ECOLI PSORT2 swissprot:YCJO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCJO_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Phobius swissprot:YCJO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCJO_ECOLI PhylomeDB P0AFR7 http://phylomedb.org/?seqid=P0AFR7 ProteinModelPortal P0AFR7 http://www.proteinmodelportal.org/query/uniprot/P0AFR7 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415827 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415827 RefSeq WP_001080790 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001080790 STRING 511145.b1311 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1311&targetmode=cogs STRING COG1175 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1175&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.1.46 http://www.tcdb.org/search/result.php?tc=3.A.1.1.46 UniProtKB YCJO_ECOLI http://www.uniprot.org/uniprot/YCJO_ECOLI UniProtKB-AC P0AFR7 http://www.uniprot.org/uniprot/P0AFR7 charge swissprot:YCJO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCJO_ECOLI eggNOG COG1175 http://eggnogapi.embl.de/nog_data/html/tree/COG1175 eggNOG ENOG4105HS6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105HS6 epestfind swissprot:YCJO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCJO_ECOLI garnier swissprot:YCJO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCJO_ECOLI helixturnhelix swissprot:YCJO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCJO_ECOLI hmoment swissprot:YCJO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCJO_ECOLI iep swissprot:YCJO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCJO_ECOLI inforesidue swissprot:YCJO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCJO_ECOLI octanol swissprot:YCJO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCJO_ECOLI pepcoil swissprot:YCJO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCJO_ECOLI pepdigest swissprot:YCJO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCJO_ECOLI pepinfo swissprot:YCJO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCJO_ECOLI pepnet swissprot:YCJO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCJO_ECOLI pepstats swissprot:YCJO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCJO_ECOLI pepwheel swissprot:YCJO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCJO_ECOLI pepwindow swissprot:YCJO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCJO_ECOLI sigcleave swissprot:YCJO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCJO_ECOLI ## Database ID URL or Descriptions # AltName LPXK_ECOLI Lipid A 4'-kinase # BioGrid 4260014 271 # CATALYTIC ACTIVITY ATP + (2-N,3-O-bis((3R)-3- hydroxytetradecanoyl)-beta-D-glucosaminyl)-(1->6)-(2-N,3-O- bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosaminyl phosphate) = ADP + (2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-4-O-phospho-beta- D-glucosaminyl)-(1->6)-(2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)- alpha-D-glucosaminyl phosphate). {ECO:0000269|PubMed 9268317}. # EcoGene EG11409 lpxK # FUNCTION LPXK_ECOLI Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). {ECO 0000269|PubMed 9268317, ECO 0000269|PubMed 9575203}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:EcoliWiki. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0009029 tetraacyldisaccharide 4'-kinase activity; IDA:EcoliWiki. # GO_function GO:0016301 kinase activity; IDA:EcoCyc. # GO_process GO:0009244 lipopolysaccharide core region biosynthetic process; IMP:EcoCyc. # GO_process GO:0009245 lipid A biosynthetic process; IDA:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.1000 -; 2. # Gene3D 3.40.50.300 -; 2. # HAMAP MF_00409 LpxK # InterPro IPR003758 Tetraacyldisaccharide_4-kinase # InterPro IPR023214 HAD-like_dom # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # KEGG_Pathway ko00540 Lipopolysaccharide biosynthesis # Organism LPXK_ECOLI Escherichia coli (strain K12) # PATHWAY Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine step 6/6. # PATRIC 32117043 VBIEscCol129921_0946 # PIR B64831 B64831 # Pfam PF02606 LpxK # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LPXK_ECOLI Tetraacyldisaccharide 4'-kinase # RefSeq NP_415435 NC_000913.3 # RefSeq WP_000570539 NZ_CP010440.1 # RefSeq WP_000570544 NZ_LN832404.1 # SIMILARITY Belongs to the LpxK family. {ECO 0000305}. # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR00682 lpxK # UniPathway UPA00359 UER00482 # eggNOG COG1663 LUCA # eggNOG ENOG4105CHD Bacteria BLAST swissprot:LPXK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LPXK_ECOLI BioCyc ECOL316407:JW0898-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0898-MONOMER BioCyc EcoCyc:TETRAACYLDISACC4KIN-MONOMER http://biocyc.org/getid?id=EcoCyc:TETRAACYLDISACC4KIN-MONOMER BioCyc MetaCyc:TETRAACYLDISACC4KIN-MONOMER http://biocyc.org/getid?id=MetaCyc:TETRAACYLDISACC4KIN-MONOMER COG COG1663 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1663 DIP DIP-10126N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10126N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.272.35.21855 http://dx.doi.org/10.1074/jbc.272.35.21855 DOI 10.1074/jbc.273.20.12457 http://dx.doi.org/10.1074/jbc.273.20.12457 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1993.tb01098.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb01098.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.130 {ECO:0000269|PubMed:9268317} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.130 {ECO:0000269|PubMed:9268317} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL Z11796 http://www.ebi.ac.uk/ena/data/view/Z11796 ENZYME 2.7.1.130 {ECO:0000269|PubMed:9268317} http://enzyme.expasy.org/EC/2.7.1.130 {ECO:0000269|PubMed:9268317} EchoBASE EB1381 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1381 EcoGene EG11409 http://www.ecogene.org/geneInfo.php?eg_id=EG11409 EnsemblBacteria AAC74001 http://www.ensemblgenomes.org/id/AAC74001 EnsemblBacteria AAC74001 http://www.ensemblgenomes.org/id/AAC74001 EnsemblBacteria BAA35661 http://www.ensemblgenomes.org/id/BAA35661 EnsemblBacteria BAA35661 http://www.ensemblgenomes.org/id/BAA35661 EnsemblBacteria BAA35661 http://www.ensemblgenomes.org/id/BAA35661 EnsemblBacteria b0915 http://www.ensemblgenomes.org/id/b0915 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0009029 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009029 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_process GO:0009244 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009244 GO_process GO:0009245 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009245 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.1000 http://www.cathdb.info/version/latest/superfamily/3.40.50.1000 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945526 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945526 HAMAP MF_00409 http://hamap.expasy.org/unirule/MF_00409 HOGENOM HOG000004953 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000004953&db=HOGENOM6 InParanoid P27300 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P27300 IntAct P27300 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P27300* IntEnz 2.7.1.130 {ECO:0000269|PubMed:9268317} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.130 {ECO:0000269|PubMed:9268317} InterPro IPR003758 http://www.ebi.ac.uk/interpro/entry/IPR003758 InterPro IPR023214 http://www.ebi.ac.uk/interpro/entry/IPR023214 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Gene ecj:JW0898 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0898 KEGG_Gene eco:b0915 http://www.genome.jp/dbget-bin/www_bget?eco:b0915 KEGG_Orthology KO:K00912 http://www.genome.jp/dbget-bin/www_bget?KO:K00912 KEGG_Pathway ko00540 http://www.genome.jp/kegg-bin/show_pathway?ko00540 KEGG_Reaction rn:R04657 http://www.genome.jp/dbget-bin/www_bget?rn:R04657 OMA PTVIYLI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PTVIYLI PSORT swissprot:LPXK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LPXK_ECOLI PSORT-B swissprot:LPXK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LPXK_ECOLI PSORT2 swissprot:LPXK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LPXK_ECOLI Pfam PF02606 http://pfam.xfam.org/family/PF02606 Phobius swissprot:LPXK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LPXK_ECOLI PhylomeDB P27300 http://phylomedb.org/?seqid=P27300 ProteinModelPortal P27300 http://www.proteinmodelportal.org/query/uniprot/P27300 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8094880 http://www.ncbi.nlm.nih.gov/pubmed/8094880 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9268317 http://www.ncbi.nlm.nih.gov/pubmed/9268317 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9575203 http://www.ncbi.nlm.nih.gov/pubmed/9575203 RefSeq NP_415435 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415435 RefSeq WP_000570539 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000570539 RefSeq WP_000570544 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000570544 SMR P27300 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P27300 STRING 511145.b0915 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0915&targetmode=cogs STRING COG1663 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1663&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR00682 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00682 UniProtKB LPXK_ECOLI http://www.uniprot.org/uniprot/LPXK_ECOLI UniProtKB-AC P27300 http://www.uniprot.org/uniprot/P27300 charge swissprot:LPXK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LPXK_ECOLI eggNOG COG1663 http://eggnogapi.embl.de/nog_data/html/tree/COG1663 eggNOG ENOG4105CHD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CHD epestfind swissprot:LPXK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LPXK_ECOLI garnier swissprot:LPXK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LPXK_ECOLI helixturnhelix swissprot:LPXK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LPXK_ECOLI hmoment swissprot:LPXK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LPXK_ECOLI iep swissprot:LPXK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LPXK_ECOLI inforesidue swissprot:LPXK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LPXK_ECOLI octanol swissprot:LPXK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LPXK_ECOLI pepcoil swissprot:LPXK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LPXK_ECOLI pepdigest swissprot:LPXK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LPXK_ECOLI pepinfo swissprot:LPXK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LPXK_ECOLI pepnet swissprot:LPXK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LPXK_ECOLI pepstats swissprot:LPXK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LPXK_ECOLI pepwheel swissprot:LPXK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LPXK_ECOLI pepwindow swissprot:LPXK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LPXK_ECOLI sigcleave swissprot:LPXK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LPXK_ECOLI ## Database ID URL or Descriptions # EcoGene EG14398 ytjA # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # HAMAP MF_01361 UPF0391 # InterPro IPR009760 DUF1328 # Organism YTJA_ECOLI Escherichia coli (strain K12) # PATRIC 32124364 VBIEscCol129921_4522 # PIRSF PIRSF036466 UCP036466 # Pfam PF07043 DUF1328 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UPF0391 membrane protein YtjA {ECO:0000255|HAMAP-Rule MF_01361} # RefSeq WP_000490275 NZ_LN832404.1 # RefSeq YP_588479 NC_000913.3 # SEQUENCE CAUTION Sequence=BAE78365.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the UPF0391 family. {ECO:0000255|HAMAP- Rule MF_01361}. # SUBCELLULAR LOCATION YTJA_ECOLI Cell membrane {ECO 0000255|HAMAP- Rule MF_01361}; Multi-pass membrane protein {ECO 0000255|HAMAP- Rule MF_01361}. BLAST swissprot:YTJA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YTJA_ECOLI BioCyc ECOL316407:JW5891-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5891-MONOMER BioCyc EcoCyc:MONOMER0-2697 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2697 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1101/gad.901001 http://dx.doi.org/10.1101/gad.901001 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14398 http://www.ecogene.org/geneInfo.php?eg_id=EG14398 EnsemblBacteria ABD18720 http://www.ensemblgenomes.org/id/ABD18720 EnsemblBacteria ABD18720 http://www.ensemblgenomes.org/id/ABD18720 EnsemblBacteria BAE78365 http://www.ensemblgenomes.org/id/BAE78365 EnsemblBacteria BAE78365 http://www.ensemblgenomes.org/id/BAE78365 EnsemblBacteria BAE78365 http://www.ensemblgenomes.org/id/BAE78365 EnsemblBacteria b4568 http://www.ensemblgenomes.org/id/b4568 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 1450298 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1450298 HAMAP MF_01361 http://hamap.expasy.org/unirule/MF_01361 HOGENOM HOG000237282 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000237282&db=HOGENOM6 InterPro IPR009760 http://www.ebi.ac.uk/interpro/entry/IPR009760 KEGG_Gene ecj:JW5891 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5891 KEGG_Gene eco:b4568 http://www.genome.jp/dbget-bin/www_bget?eco:b4568 OMA RWAILFA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RWAILFA PSORT swissprot:YTJA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YTJA_ECOLI PSORT-B swissprot:YTJA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YTJA_ECOLI PSORT2 swissprot:YTJA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YTJA_ECOLI Pfam PF07043 http://pfam.xfam.org/family/PF07043 Phobius swissprot:YTJA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YTJA_ECOLI PubMed 11445539 http://www.ncbi.nlm.nih.gov/pubmed/11445539 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000490275 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000490275 RefSeq YP_588479 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_588479 STRING 511145.b4568 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4568&targetmode=cogs UniProtKB YTJA_ECOLI http://www.uniprot.org/uniprot/YTJA_ECOLI UniProtKB-AC Q2M5U1 http://www.uniprot.org/uniprot/Q2M5U1 charge swissprot:YTJA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YTJA_ECOLI epestfind swissprot:YTJA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YTJA_ECOLI garnier swissprot:YTJA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YTJA_ECOLI helixturnhelix swissprot:YTJA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YTJA_ECOLI hmoment swissprot:YTJA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YTJA_ECOLI iep swissprot:YTJA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YTJA_ECOLI inforesidue swissprot:YTJA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YTJA_ECOLI octanol swissprot:YTJA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YTJA_ECOLI pepcoil swissprot:YTJA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YTJA_ECOLI pepdigest swissprot:YTJA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YTJA_ECOLI pepinfo swissprot:YTJA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YTJA_ECOLI pepnet swissprot:YTJA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YTJA_ECOLI pepstats swissprot:YTJA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YTJA_ECOLI pepwheel swissprot:YTJA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YTJA_ECOLI pepwindow swissprot:YTJA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YTJA_ECOLI sigcleave swissprot:YTJA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YTJA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260346 6 # CATALYTIC ACTIVITY ADRB_ECOLI Cyclic di-3',5'-guanylate + H(2)O = 5'- phosphoguanylyl(3'->5')guanosine. # CDD cd01948 EAL # DISRUPTION PHENOTYPE Cells lacking this gene show increased aggregation, increased cellulose production but no increase in surface attachment. {ECO:0000269|PubMed 16513732}. # EcoGene EG13516 adrB # FUNCTION ADRB_ECOLI May serve as a negative regulator of cellulose synthesis (as has been suggested for S.typhimurium); overexpression inhibits cell aggregation in strains able to produce adhesive curli fimbriae. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria. # GO_function GO:0071111 cyclic-guanylate-specific phosphodiesterase activity; IEA:UniProtKB-EC. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006950 response to stress # Gene3D 3.20.20.450 -; 1. # INDUCTION ADRB_ECOLI Expressed at 28 degrees Celsius in late stationary phase, constitutively expressed at low levels at 37 degrees Celsius, more highly expressed on plates than in liquid medium. Expression is RpoS- and CsgD-dependent. {ECO 0000269|PubMed 16513732, ECO 0000269|PubMed 19332833}. # InterPro IPR001633 EAL_dom # InterPro IPR024744 CSS-motif_dom # Organism ADRB_ECOLI Escherichia coli (strain K12) # PATRIC 32118949 VBIEscCol129921_1892 # PIR G64942 G64942 # PROSITE PS50883 EAL # Pfam PF00563 EAL # Pfam PF12792 CSS-motif # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ADRB_ECOLI Putative cyclic-di-GMP phosphodiesterase AdrB # RefSeq NP_416329 NC_000913.3 # RefSeq WP_001295494 NZ_LN832404.1 # SIMILARITY Contains 1 EAL domain. {ECO:0000255|PROSITE- ProRule PRU00074}. # SMART SM00052 EAL # SUPFAM SSF141868 SSF141868 # eggNOG COG2200 LUCA # eggNOG ENOG4107XTP Bacteria BLAST swissprot:ADRB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ADRB_ECOLI BioCyc ECOL316407:JW1804-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1804-MONOMER BioCyc EcoCyc:G6996-MONOMER http://biocyc.org/getid?id=EcoCyc:G6996-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1099/mic.0.024257-0 http://dx.doi.org/10.1099/mic.0.024257-0 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.188.6.2027-2037.2006 http://dx.doi.org/10.1128/JB.188.6.2027-2037.2006 EC_number EC:3.1.4.52 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.4.52 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.4.52 http://enzyme.expasy.org/EC/3.1.4.52 EchoBASE EB3289 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3289 EcoGene EG13516 http://www.ecogene.org/geneInfo.php?eg_id=EG13516 EnsemblBacteria AAC74885 http://www.ensemblgenomes.org/id/AAC74885 EnsemblBacteria AAC74885 http://www.ensemblgenomes.org/id/AAC74885 EnsemblBacteria BAA15622 http://www.ensemblgenomes.org/id/BAA15622 EnsemblBacteria BAA15622 http://www.ensemblgenomes.org/id/BAA15622 EnsemblBacteria BAA15622 http://www.ensemblgenomes.org/id/BAA15622 EnsemblBacteria b1815 http://www.ensemblgenomes.org/id/b1815 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0071111 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071111 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.20.20.450 http://www.cathdb.info/version/latest/superfamily/3.20.20.450 GeneID 946336 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946336 HOGENOM HOG000273106 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000273106&db=HOGENOM6 InParanoid P76261 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76261 IntAct P76261 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76261* IntEnz 3.1.4.52 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.4.52 InterPro IPR001633 http://www.ebi.ac.uk/interpro/entry/IPR001633 InterPro IPR024744 http://www.ebi.ac.uk/interpro/entry/IPR024744 KEGG_Gene ecj:JW1804 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1804 KEGG_Gene eco:b1815 http://www.genome.jp/dbget-bin/www_bget?eco:b1815 OMA VYCQPII http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VYCQPII PROSITE PS50883 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50883 PSORT swissprot:ADRB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ADRB_ECOLI PSORT-B swissprot:ADRB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ADRB_ECOLI PSORT2 swissprot:ADRB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ADRB_ECOLI Pfam PF00563 http://pfam.xfam.org/family/PF00563 Pfam PF12792 http://pfam.xfam.org/family/PF12792 Phobius swissprot:ADRB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ADRB_ECOLI PhylomeDB P76261 http://phylomedb.org/?seqid=P76261 ProteinModelPortal P76261 http://www.proteinmodelportal.org/query/uniprot/P76261 PubMed 16513732 http://www.ncbi.nlm.nih.gov/pubmed/16513732 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19332833 http://www.ncbi.nlm.nih.gov/pubmed/19332833 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416329 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416329 RefSeq WP_001295494 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295494 SMART SM00052 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00052 SMR P76261 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76261 STRING 511145.b1815 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1815&targetmode=cogs SUPFAM SSF141868 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF141868 UniProtKB ADRB_ECOLI http://www.uniprot.org/uniprot/ADRB_ECOLI UniProtKB-AC P76261 http://www.uniprot.org/uniprot/P76261 charge swissprot:ADRB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ADRB_ECOLI eggNOG COG2200 http://eggnogapi.embl.de/nog_data/html/tree/COG2200 eggNOG ENOG4107XTP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107XTP epestfind swissprot:ADRB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ADRB_ECOLI garnier swissprot:ADRB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ADRB_ECOLI helixturnhelix swissprot:ADRB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ADRB_ECOLI hmoment swissprot:ADRB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ADRB_ECOLI iep swissprot:ADRB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ADRB_ECOLI inforesidue swissprot:ADRB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ADRB_ECOLI octanol swissprot:ADRB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ADRB_ECOLI pepcoil swissprot:ADRB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ADRB_ECOLI pepdigest swissprot:ADRB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ADRB_ECOLI pepinfo swissprot:ADRB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ADRB_ECOLI pepnet swissprot:ADRB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ADRB_ECOLI pepstats swissprot:ADRB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ADRB_ECOLI pepwheel swissprot:ADRB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ADRB_ECOLI pepwindow swissprot:ADRB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ADRB_ECOLI sigcleave swissprot:ADRB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ADRB_ECOLI ## Database ID URL or Descriptions # CATALYTIC ACTIVITY RUTE_ECOLI 3-hydroxypropanoate + NADP(+) = 3- oxopropanoate + NADPH. # CDD cd02148 Nitroreductase_5 # COFACTOR Name=FMN; Xref=ChEBI:CHEBI 58210; Evidence={ECO:0000305}; # DISRUPTION PHENOTYPE RUTE_ECOLI Cells lacking this gene lose the ability to utilize pyrimidine nucleosides and bases as the sole source of nitrogen at room temperature. {ECO 0000269|PubMed 16540542, ECO 0000269|PubMed 20400551}. # EcoGene EG13855 rutE # FUNCTION RUTE_ECOLI May reduce toxic product malonic semialdehyde to 3- hydroxypropionic acid, which is excreted. RutE is apparently supplemented by YdfG. Required in vivo, but not in vitro in pyrimidine nitrogen degradation. {ECO 0000269|PubMed 16540542}. # GO_function GO:0010181 FMN binding; IDA:EcoCyc. # GO_function GO:0035527 3-hydroxypropionate dehydrogenase (NADP+) activity; IEA:UniProtKB-HAMAP. # GO_process GO:0006208 pyrimidine nucleobase catabolic process; IMP:EcoCyc. # GO_process GO:0006212 uracil catabolic process; IDA:UniProtKB. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0019740 nitrogen utilization; IDA:UniProtKB. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.109.10 -; 1. # HAMAP MF_01204 Oxidoreductase_RutE_HadB # INDUCTION RUTE_ECOLI Up-regulated by the nitrogen regulatory protein C (NtrC also called GlnG) and repressed by RutR. {ECO 0000269|PubMed 11121068, ECO 0000269|PubMed 17919280}. # InterPro IPR000415 Nitroreductase-like # InterPro IPR023936 Nitroreductase_RutE # InterPro IPR029479 Nitroreductase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00240 Pyrimidine metabolism # MISCELLANEOUS RUTE_ECOLI The Rut pathway degrades exogenous pyrimidines as the sole nitrogen source at room temperature but not at 37 degrees Celsius, a restriction that is apparently a consequence of an inadequate ability to remove toxic malonic semialdehyde at the higher temperature (RutE/YdfG function). # Organism RUTE_ECOLI Escherichia coli (strain K12) # PATRIC 32117245 VBIEscCol129921_1046 # PIR F64842 F64842 # Pfam PF00881 Nitroreductase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RUTE_ECOLI Probable malonic semialdehyde reductase RutE # RefSeq NP_415528 NC_000913.3 # RefSeq WP_001001176 NZ_LN832404.1 # SIMILARITY Belongs to the nitroreductase family. HadB/RutE subfamily. {ECO 0000305}. # SUPFAM SSF55469 SSF55469 # eggNOG COG0778 LUCA # eggNOG ENOG4108RDT Bacteria BLAST swissprot:RUTE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RUTE_ECOLI BioCyc ECOL316407:JW0993-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0993-MONOMER BioCyc EcoCyc:G6519-MONOMER http://biocyc.org/getid?id=EcoCyc:G6519-MONOMER BioCyc MetaCyc:G6519-MONOMER http://biocyc.org/getid?id=MetaCyc:G6519-MONOMER COG COG0778 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0778 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0600521103 http://dx.doi.org/10.1073/pnas.0600521103 DOI 10.1073/pnas.97.26.14674 http://dx.doi.org/10.1073/pnas.97.26.14674 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.2007.05954.x http://dx.doi.org/10.1111/j.1365-2958.2007.05954.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00201-10 http://dx.doi.org/10.1128/JB.00201-10 EC_number EC:1.1.1.298 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.298 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.1.1.298 http://enzyme.expasy.org/EC/1.1.1.298 EchoBASE EB3615 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3615 EcoGene EG13855 http://www.ecogene.org/geneInfo.php?eg_id=EG13855 EnsemblBacteria AAC74093 http://www.ensemblgenomes.org/id/AAC74093 EnsemblBacteria AAC74093 http://www.ensemblgenomes.org/id/AAC74093 EnsemblBacteria BAA35775 http://www.ensemblgenomes.org/id/BAA35775 EnsemblBacteria BAA35775 http://www.ensemblgenomes.org/id/BAA35775 EnsemblBacteria BAA35775 http://www.ensemblgenomes.org/id/BAA35775 EnsemblBacteria b1008 http://www.ensemblgenomes.org/id/b1008 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0010181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010181 GO_function GO:0035527 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035527 GO_process GO:0006208 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006208 GO_process GO:0006212 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006212 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0019740 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019740 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.109.10 http://www.cathdb.info/version/latest/superfamily/3.40.109.10 GeneID 946591 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946591 HAMAP MF_01204 http://hamap.expasy.org/unirule/MF_01204 HOGENOM HOG000236370 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000236370&db=HOGENOM6 InParanoid P75894 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75894 IntEnz 1.1.1.298 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.298 InterPro IPR000415 http://www.ebi.ac.uk/interpro/entry/IPR000415 InterPro IPR023936 http://www.ebi.ac.uk/interpro/entry/IPR023936 InterPro IPR029479 http://www.ebi.ac.uk/interpro/entry/IPR029479 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0993 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0993 KEGG_Gene eco:b1008 http://www.genome.jp/dbget-bin/www_bget?eco:b1008 KEGG_Orthology KO:K09019 http://www.genome.jp/dbget-bin/www_bget?KO:K09019 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Reaction rn:R09289 http://www.genome.jp/dbget-bin/www_bget?rn:R09289 OMA THNGWLD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=THNGWLD PSORT swissprot:RUTE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RUTE_ECOLI PSORT-B swissprot:RUTE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RUTE_ECOLI PSORT2 swissprot:RUTE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RUTE_ECOLI Pfam PF00881 http://pfam.xfam.org/family/PF00881 Phobius swissprot:RUTE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RUTE_ECOLI PhylomeDB P75894 http://phylomedb.org/?seqid=P75894 ProteinModelPortal P75894 http://www.proteinmodelportal.org/query/uniprot/P75894 PubMed 11121068 http://www.ncbi.nlm.nih.gov/pubmed/11121068 PubMed 16540542 http://www.ncbi.nlm.nih.gov/pubmed/16540542 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17919280 http://www.ncbi.nlm.nih.gov/pubmed/17919280 PubMed 20400551 http://www.ncbi.nlm.nih.gov/pubmed/20400551 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415528 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415528 RefSeq WP_001001176 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001001176 SMR P75894 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75894 STRING 511145.b1008 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1008&targetmode=cogs STRING COG0778 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0778&targetmode=cogs SUPFAM SSF55469 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55469 UniProtKB RUTE_ECOLI http://www.uniprot.org/uniprot/RUTE_ECOLI UniProtKB-AC P75894 http://www.uniprot.org/uniprot/P75894 charge swissprot:RUTE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RUTE_ECOLI eggNOG COG0778 http://eggnogapi.embl.de/nog_data/html/tree/COG0778 eggNOG ENOG4108RDT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108RDT epestfind swissprot:RUTE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RUTE_ECOLI garnier swissprot:RUTE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RUTE_ECOLI helixturnhelix swissprot:RUTE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RUTE_ECOLI hmoment swissprot:RUTE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RUTE_ECOLI iep swissprot:RUTE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RUTE_ECOLI inforesidue swissprot:RUTE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RUTE_ECOLI octanol swissprot:RUTE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RUTE_ECOLI pepcoil swissprot:RUTE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RUTE_ECOLI pepdigest swissprot:RUTE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RUTE_ECOLI pepinfo swissprot:RUTE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RUTE_ECOLI pepnet swissprot:RUTE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RUTE_ECOLI pepstats swissprot:RUTE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RUTE_ECOLI pepwheel swissprot:RUTE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RUTE_ECOLI pepwindow swissprot:RUTE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RUTE_ECOLI sigcleave swissprot:RUTE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RUTE_ECOLI ## Database ID URL or Descriptions # BioGrid 4260749 17 # EcoGene EG14168 ypeA # GO_component GO:0031248 protein acetyltransferase complex; IBA:GO_Central. # GO_function GO:0004596 peptide alpha-N-acetyltransferase activity; IBA:GO_Central. # GO_process GO:0006474 N-terminal protein amino acid acetylation; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0006464 cellular protein modification process # Gene3D 3.40.630.30 -; 1. # HAMAP MF_01127 Acetyltransf_YpeA # IntAct P76539 9 # InterPro IPR000182 GNAT_dom # InterPro IPR016181 Acyl_CoA_acyltransferase # InterPro IPR023072 Acetyltransferase_YpeA # Organism YPEA_ECOLI Escherichia coli (strain K12) # PATRIC 32120253 VBIEscCol129921_2529 # PDB 4QUS X-ray; 1.28 A; A/B=1-141 # PDB 4QVT X-ray; 1.95 A; A/B/C/D/E/F/G/H=1-141 # PIR A65018 A65018 # PROSITE PS51186 GNAT # Pfam PF00583 Acetyltransf_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YPEA_ECOLI Acetyltransferase YpeA # RefSeq NP_416929 NC_000913.3 # RefSeq WP_000405996 NZ_LN832404.1 # SIMILARITY Belongs to the acetyltransferase family. YpeA subfamily. {ECO 0000305}. # SIMILARITY Contains 1 N-acetyltransferase domain. {ECO 0000305}. # SUPFAM SSF55729 SSF55729 # eggNOG COG0456 LUCA # eggNOG ENOG4108R6G Bacteria BLAST swissprot:YPEA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YPEA_ECOLI BioCyc ECOL316407:JW2427-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2427-MONOMER BioCyc EcoCyc:G7269-MONOMER http://biocyc.org/getid?id=EcoCyc:G7269-MONOMER DIP DIP-28085N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-28085N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.3.1.- http://enzyme.expasy.org/EC/2.3.1.- EchoBASE EB3920 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3920 EcoGene EG14168 http://www.ecogene.org/geneInfo.php?eg_id=EG14168 EnsemblBacteria AAC75487 http://www.ensemblgenomes.org/id/AAC75487 EnsemblBacteria AAC75487 http://www.ensemblgenomes.org/id/AAC75487 EnsemblBacteria BAE76714 http://www.ensemblgenomes.org/id/BAE76714 EnsemblBacteria BAE76714 http://www.ensemblgenomes.org/id/BAE76714 EnsemblBacteria BAE76714 http://www.ensemblgenomes.org/id/BAE76714 EnsemblBacteria b2434 http://www.ensemblgenomes.org/id/b2434 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0031248 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031248 GO_function GO:0004596 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004596 GO_process GO:0006474 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006474 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 Gene3D 3.40.630.30 http://www.cathdb.info/version/latest/superfamily/3.40.630.30 GeneID 946917 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946917 HAMAP MF_01127 http://hamap.expasy.org/unirule/MF_01127 HOGENOM HOG000078526 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000078526&db=HOGENOM6 InParanoid P76539 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76539 IntAct P76539 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76539* IntEnz 2.3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1 InterPro IPR000182 http://www.ebi.ac.uk/interpro/entry/IPR000182 InterPro IPR016181 http://www.ebi.ac.uk/interpro/entry/IPR016181 InterPro IPR023072 http://www.ebi.ac.uk/interpro/entry/IPR023072 KEGG_Gene ecj:JW2427 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2427 KEGG_Gene eco:b2434 http://www.genome.jp/dbget-bin/www_bget?eco:b2434 OMA QIMVRED http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QIMVRED PDB 4QUS http://www.ebi.ac.uk/pdbe-srv/view/entry/4QUS PDB 4QVT http://www.ebi.ac.uk/pdbe-srv/view/entry/4QVT PDBsum 4QUS http://www.ebi.ac.uk/pdbsum/4QUS PDBsum 4QVT http://www.ebi.ac.uk/pdbsum/4QVT PROSITE PS51186 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51186 PSORT swissprot:YPEA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YPEA_ECOLI PSORT-B swissprot:YPEA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YPEA_ECOLI PSORT2 swissprot:YPEA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YPEA_ECOLI Pfam PF00583 http://pfam.xfam.org/family/PF00583 Phobius swissprot:YPEA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YPEA_ECOLI PhylomeDB P76539 http://phylomedb.org/?seqid=P76539 ProteinModelPortal P76539 http://www.proteinmodelportal.org/query/uniprot/P76539 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416929 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416929 RefSeq WP_000405996 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000405996 SMR P76539 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76539 STRING 511145.b2434 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2434&targetmode=cogs SUPFAM SSF55729 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55729 UniProtKB YPEA_ECOLI http://www.uniprot.org/uniprot/YPEA_ECOLI UniProtKB-AC P76539 http://www.uniprot.org/uniprot/P76539 charge swissprot:YPEA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YPEA_ECOLI eggNOG COG0456 http://eggnogapi.embl.de/nog_data/html/tree/COG0456 eggNOG ENOG4108R6G http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108R6G epestfind swissprot:YPEA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YPEA_ECOLI garnier swissprot:YPEA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YPEA_ECOLI helixturnhelix swissprot:YPEA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YPEA_ECOLI hmoment swissprot:YPEA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YPEA_ECOLI iep swissprot:YPEA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YPEA_ECOLI inforesidue swissprot:YPEA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YPEA_ECOLI octanol swissprot:YPEA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YPEA_ECOLI pepcoil swissprot:YPEA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YPEA_ECOLI pepdigest swissprot:YPEA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YPEA_ECOLI pepinfo swissprot:YPEA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YPEA_ECOLI pepnet swissprot:YPEA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YPEA_ECOLI pepstats swissprot:YPEA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YPEA_ECOLI pepwheel swissprot:YPEA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YPEA_ECOLI pepwindow swissprot:YPEA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YPEA_ECOLI sigcleave swissprot:YPEA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YPEA_ECOLI ## Database ID URL or Descriptions # EcoGene EG10875 rplN # FUNCTION RL14_ECOLI Can also interact with RsfS, in this case bridge B8 probably cannot form, and the 30S and 50S ribosomal subunits do not associate, which represses translation. {ECO 0000269|PubMed 22829778}. # FUNCTION RL14_ECOLI This protein binds directly to 23S ribosomal RNA. In the E.coli 70S ribosome it has been modeled to make two contacts with the 16S rRNA of the 30S subunit, forming part of bridges B5 and B8, connecting the 2 subunits (PubMed 12809609). Although the protein undergoes significant rotation during the transition from an initiation to and EF-G bound state, the bridges remain stable. In the 3.5 A resolved structures L14 and L19 interact and together make contact with the 16S rRNA in bridges B5 and B8 (PubMed 16272117). {ECO 0000269|PubMed 12809609, ECO 0000269|PubMed 16272117, ECO 0000269|PubMed 22829778}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0022625 cytosolic large ribosomal subunit; IDA:EcoCyc. # GO_function GO:0003735 structural constituent of ribosome; IBA:GO_Central. # GO_function GO:0070180 large ribosomal subunit rRNA binding; IDA:EcoCyc. # GO_process GO:0006412 translation; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_function GO:0019843 rRNA binding # GOslim_process GO:0006412 translation # Gene3D 2.40.150.20 -; 1. # HAMAP MF_01367 Ribosomal_L14 # IntAct P0ADY3 49 # InterPro IPR000218 Ribosomal_L14P # InterPro IPR005745 Ribosomal_L14P_bac-type # InterPro IPR019972 Ribosomal_L14P_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 M00179 Ribosome, archaea # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=13540.2; Method=MALDI; Range=1-123; Evidence={ECO:0000269|PubMed 10094780}; # Organism RL14_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11761 PTHR11761 # PATRIC 32122052 VBIEscCol129921_3403 # PDB 1ML5 EM; 14.00 A; n=1-122 # PDB 2J28 EM; 8.00 A; K=2-122 # PDB 2RDO EM; 9.10 A; K=1-123 # PDB 3BBX EM; 10.00 A; K=1-123 # PDB 3IY9 EM; 14.10 A; K=2-122 # PDB 3IZZ EM; 10.80 A; G=2-122 # PDB 3J5L EM; 6.60 A; K=1-122 # PDB 3J7Z EM; 3.90 A; K=1-123 # PDB 3J8G EM; 5.00 A; K=1-123 # PDB 3J9Y EM; 3.90 A; K=1-123 # PDB 3J9Z EM; 3.60 A; LG=1-123 # PDB 3JA1 EM; 3.60 A; LM=1-123 # PDB 3JBU EM; 3.64 A; k=1-123 # PDB 3JBV EM; 3.32 A; k=1-123 # PDB 3JCD EM; 3.70 A; K=1-123 # PDB 3JCE EM; 3.20 A; K=1-123 # PDB 3JCJ EM; 3.70 A; J=1-123 # PDB 3JCN EM; 4.60 A; K=1-123 # PDB 487D EM; 7.50 A; M=1-122 # PDB 4CSU EM; 5.50 A; K=1-123 # PDB 4U1U X-ray; 2.95 A; BK/DK=1-122 # PDB 4U1V X-ray; 3.00 A; BK/DK=1-122 # PDB 4U20 X-ray; 2.90 A; BK/DK=1-122 # PDB 4U24 X-ray; 2.90 A; BK/DK=1-122 # PDB 4U25 X-ray; 2.90 A; BK/DK=1-122 # PDB 4U26 X-ray; 2.80 A; BK/DK=1-122 # PDB 4U27 X-ray; 2.80 A; BK/DK=1-122 # PDB 4UY8 EM; 3.80 A; K=1-122 # PDB 4V47 EM; 12.30 A; AI=1-123 # PDB 4V48 EM; 11.50 A; AI=1-123 # PDB 4V4H X-ray; 3.46 A; BK/DK=1-123 # PDB 4V4Q X-ray; 3.46 A; BK/DK=1-123 # PDB 4V4V EM; 15.00 A; BI=2-123 # PDB 4V4W EM; 15.00 A; BI=2-123 # PDB 4V50 X-ray; 3.22 A; BK/DK=1-123 # PDB 4V52 X-ray; 3.21 A; BK/DK=1-123 # PDB 4V53 X-ray; 3.54 A; BK/DK=1-123 # PDB 4V54 X-ray; 3.30 A; BK/DK=1-123 # PDB 4V55 X-ray; 4.00 A; BK/DK=1-123 # PDB 4V56 X-ray; 3.93 A; BK/DK=1-123 # PDB 4V57 X-ray; 3.50 A; BK/DK=1-123 # PDB 4V5B X-ray; 3.74 A; AK/CK=1-123 # PDB 4V5H EM; 5.80 A; BK=1-121 # PDB 4V5Y X-ray; 4.45 A; BK/DK=1-123 # PDB 4V64 X-ray; 3.50 A; BK/DK=1-123 # PDB 4V65 EM; 9.00 A; BD=1-123 # PDB 4V66 EM; 9.00 A; BD=1-123 # PDB 4V69 EM; 6.70 A; BK=2-122 # PDB 4V6C X-ray; 3.19 A; BK/DK=1-123 # PDB 4V6D X-ray; 3.81 A; BK/DK=1-123 # PDB 4V6E X-ray; 3.71 A; BK/DK=1-123 # PDB 4V6K EM; 8.25 A; AL=1-123 # PDB 4V6L EM; 13.20 A; BL=1-123 # PDB 4V6M EM; 7.10 A; BK=1-123 # PDB 4V6N EM; 12.10 A; AM=1-123 # PDB 4V6O EM; 14.70 A; BM=1-123 # PDB 4V6P EM; 13.50 A; BM=1-123 # PDB 4V6Q EM; 11.50 A; BM=1-123 # PDB 4V6R EM; 11.50 A; BM=1-123 # PDB 4V6S EM; 13.10 A; AM=1-123 # PDB 4V6T EM; 8.30 A; BK=1-122 # PDB 4V6V EM; 9.80 A; BO=1-123 # PDB 4V6Y EM; 12.00 A; BK=1-122 # PDB 4V6Z EM; 12.00 A; BK=1-122 # PDB 4V70 EM; 17.00 A; BK=1-122 # PDB 4V71 EM; 20.00 A; BK=1-122 # PDB 4V72 EM; 13.00 A; BK=1-122 # PDB 4V73 EM; 15.00 A; BK=1-122 # PDB 4V74 EM; 17.00 A; BK=1-122 # PDB 4V75 EM; 12.00 A; BK=1-122 # PDB 4V76 EM; 17.00 A; BK=1-122 # PDB 4V77 EM; 17.00 A; BK=1-122 # PDB 4V78 EM; 20.00 A; BK=1-122 # PDB 4V79 EM; 15.00 A; BK=1-122 # PDB 4V7A EM; 9.00 A; BK=1-122 # PDB 4V7B EM; 6.80 A; BK=1-123 # PDB 4V7C EM; 7.60 A; BM=1-123 # PDB 4V7D EM; 7.60 A; AN=1-123 # PDB 4V7I EM; 9.60 A; AK=1-123 # PDB 4V7S X-ray; 3.25 A; BK/DK=1-122 # PDB 4V7T X-ray; 3.19 A; BK/DK=1-122 # PDB 4V7U X-ray; 3.10 A; BK/DK=1-122 # PDB 4V7V X-ray; 3.29 A; BK/DK=1-122 # PDB 4V85 X-ray; 3.20 A; O=1-123 # PDB 4V89 X-ray; 3.70 A; BO=1-123 # PDB 4V9C X-ray; 3.30 A; BK/DK=1-123 # PDB 4V9D X-ray; 3.00 A; CK/DK=1-122 # PDB 4V9O X-ray; 2.90 A; AK/CK/EK/GK=1-123 # PDB 4V9P X-ray; 2.90 A; AK/CK/EK/GK=1-123 # PDB 4WF1 X-ray; 3.09 A; BK/DK=1-122 # PDB 4WOI X-ray; 3.00 A; BK/CK=1-123 # PDB 4WWW X-ray; 3.10 A; RK/YK=1-122 # PDB 4YBB X-ray; 2.10 A; CL/DL=1-123 # PDB 5ADY EM; 4.50 A; K=1-123 # PDB 5AFI EM; 2.90 A; K=1-123 # PDB 5AKA EM; 5.70 A; K=1-123 # PDB 5GAD EM; 3.70 A; L=1-123 # PDB 5GAE EM; 3.33 A; L=1-123 # PDB 5GAF EM; 4.30 A; L=1-123 # PDB 5GAG EM; 3.80 A; L=1-123 # PDB 5GAH EM; 3.80 A; L=1-123 # PDB 5IQR EM; 3.00 A; K=1-123 # PDB 5IT8 X-ray; 3.12 A; CL/DL=1-123 # PDB 5J5B X-ray; 2.80 A; CL/DL=1-123 # PDB 5J7L X-ray; 3.00 A; CL/DL=1-123 # PDB 5J88 X-ray; 3.32 A; CL/DL=1-123 # PDB 5J8A X-ray; 3.10 A; CL/DL=1-123 # PDB 5J91 X-ray; 2.96 A; CL/DL=1-123 # PDB 5JC9 X-ray; 3.03 A; CL/DL=1-123 # PDB 5JTE EM; 3.60 A; BK=1-123 # PDB 5JU8 EM; 3.60 A; BK=1-123 # PDB 5KCR EM; 3.60 A; 1O=1-123 # PDB 5KCS EM; 3.90 A; 1O=1-123 # PDB 5KPS EM; 3.90 A; K=1-123 # PDB 5KPV EM; 4.10 A; J=1-123 # PDB 5KPW EM; 3.90 A; J=1-123 # PDB 5KPX EM; 3.90 A; J=1-123 # PDB 5L3P EM; 3.70 A; O=1-123 # PIR A65124 R5EC14 # PROSITE PS00049 RIBOSOMAL_L14 # Pfam PF00238 Ribosomal_L14 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 50S ribosomal protein L14 {ECO:0000255|HAMAP-Rule MF_01367} # RefSeq NP_417769 NC_000913.3 # RefSeq WP_000613955 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein L14P family. {ECO:0000255|HAMAP-Rule MF_01367}. # SMART SM01374 Ribosomal_L14 # SUBUNIT RL14_ECOLI Part of the 50S ribosomal subunit. Contacts L19 (PubMed 2665813, PubMed 16272117). Forms two bridges to the 30S subunit in the 70S ribosome, contacting the 16S rRNA. Can also contact RsfS, which then probably inhibits ribosomal subunit association. {ECO 0000269|PubMed 16272117, ECO 0000269|PubMed 2665813}. # SUPFAM SSF50193 SSF50193 # TIGRFAMs TIGR01067 rplN_bact # eggNOG COG0093 LUCA # eggNOG ENOG4108UNN Bacteria BLAST swissprot:RL14_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RL14_ECOLI BioCyc ECOL316407:JW3272-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3272-MONOMER BioCyc EcoCyc:EG10875-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10875-MONOMER BioCyc MetaCyc:EG10875-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10875-MONOMER COG COG0093 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0093 DIP DIP-35798N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35798N DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1006/jmbi.2000.3635 http://dx.doi.org/10.1006/jmbi.2000.3635 DOI 10.1016/0014-5793(78)80020-9 http://dx.doi.org/10.1016/0014-5793(78)80020-9 DOI 10.1016/0092-8674(78)90096-X http://dx.doi.org/10.1016/0092-8674(78)90096-X DOI 10.1016/S0092-8674(03)00427-6 http://dx.doi.org/10.1016/S0092-8674(03)00427-6 DOI 10.1016/j.celrep.2014.09.011 http://dx.doi.org/10.1016/j.celrep.2014.09.011 DOI 10.1021/bi00435a071 http://dx.doi.org/10.1021/bi00435a071 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/11.9.2599 http://dx.doi.org/10.1093/nar/11.9.2599 DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pbio.1001866 http://dx.doi.org/10.1371/journal.pbio.1001866 DOI 10.1371/journal.pgen.1002815 http://dx.doi.org/10.1371/journal.pgen.1002815 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL V00357 http://www.ebi.ac.uk/ena/data/view/V00357 EMBL X01563 http://www.ebi.ac.uk/ena/data/view/X01563 EchoBASE EB0868 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0868 EcoGene EG10875 http://www.ecogene.org/geneInfo.php?eg_id=EG10875 EnsemblBacteria AAC76335 http://www.ensemblgenomes.org/id/AAC76335 EnsemblBacteria AAC76335 http://www.ensemblgenomes.org/id/AAC76335 EnsemblBacteria BAE77981 http://www.ensemblgenomes.org/id/BAE77981 EnsemblBacteria BAE77981 http://www.ensemblgenomes.org/id/BAE77981 EnsemblBacteria BAE77981 http://www.ensemblgenomes.org/id/BAE77981 EnsemblBacteria b3310 http://www.ensemblgenomes.org/id/b3310 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0022625 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022625 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_function GO:0070180 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070180 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 Gene3D 2.40.150.20 http://www.cathdb.info/version/latest/superfamily/2.40.150.20 GeneID 947809 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947809 HAMAP MF_01367 http://hamap.expasy.org/unirule/MF_01367 HOGENOM HOG000183702 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000183702&db=HOGENOM6 InParanoid P0ADY3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADY3 IntAct P0ADY3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADY3* InterPro IPR000218 http://www.ebi.ac.uk/interpro/entry/IPR000218 InterPro IPR005745 http://www.ebi.ac.uk/interpro/entry/IPR005745 InterPro IPR019972 http://www.ebi.ac.uk/interpro/entry/IPR019972 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW3272 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3272 KEGG_Gene eco:b3310 http://www.genome.jp/dbget-bin/www_bget?eco:b3310 KEGG_Orthology KO:K02874 http://www.genome.jp/dbget-bin/www_bget?KO:K02874 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 MINT MINT-1304553 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1304553 OMA LRDKQFM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LRDKQFM PANTHER PTHR11761 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11761 PDB 1ML5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ML5 PDB 2J28 http://www.ebi.ac.uk/pdbe-srv/view/entry/2J28 PDB 2RDO http://www.ebi.ac.uk/pdbe-srv/view/entry/2RDO PDB 3BBX http://www.ebi.ac.uk/pdbe-srv/view/entry/3BBX PDB 3IY9 http://www.ebi.ac.uk/pdbe-srv/view/entry/3IY9 PDB 3IZZ http://www.ebi.ac.uk/pdbe-srv/view/entry/3IZZ PDB 3J5L http://www.ebi.ac.uk/pdbe-srv/view/entry/3J5L PDB 3J7Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J7Z PDB 3J8G http://www.ebi.ac.uk/pdbe-srv/view/entry/3J8G PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 487D http://www.ebi.ac.uk/pdbe-srv/view/entry/487D PDB 4CSU http://www.ebi.ac.uk/pdbe-srv/view/entry/4CSU PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4UY8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4UY8 PDB 4V47 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V47 PDB 4V48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V48 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5ADY http://www.ebi.ac.uk/pdbe-srv/view/entry/5ADY PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5AKA http://www.ebi.ac.uk/pdbe-srv/view/entry/5AKA PDB 5GAD http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAD PDB 5GAE http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAE PDB 5GAF http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAF PDB 5GAG http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAG PDB 5GAH http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAH PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 1ML5 http://www.ebi.ac.uk/pdbsum/1ML5 PDBsum 2J28 http://www.ebi.ac.uk/pdbsum/2J28 PDBsum 2RDO http://www.ebi.ac.uk/pdbsum/2RDO PDBsum 3BBX http://www.ebi.ac.uk/pdbsum/3BBX PDBsum 3IY9 http://www.ebi.ac.uk/pdbsum/3IY9 PDBsum 3IZZ http://www.ebi.ac.uk/pdbsum/3IZZ PDBsum 3J5L http://www.ebi.ac.uk/pdbsum/3J5L PDBsum 3J7Z http://www.ebi.ac.uk/pdbsum/3J7Z PDBsum 3J8G http://www.ebi.ac.uk/pdbsum/3J8G PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 487D http://www.ebi.ac.uk/pdbsum/487D PDBsum 4CSU http://www.ebi.ac.uk/pdbsum/4CSU PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4UY8 http://www.ebi.ac.uk/pdbsum/4UY8 PDBsum 4V47 http://www.ebi.ac.uk/pdbsum/4V47 PDBsum 4V48 http://www.ebi.ac.uk/pdbsum/4V48 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5ADY http://www.ebi.ac.uk/pdbsum/5ADY PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5AKA http://www.ebi.ac.uk/pdbsum/5AKA PDBsum 5GAD http://www.ebi.ac.uk/pdbsum/5GAD PDBsum 5GAE http://www.ebi.ac.uk/pdbsum/5GAE PDBsum 5GAF http://www.ebi.ac.uk/pdbsum/5GAF PDBsum 5GAG http://www.ebi.ac.uk/pdbsum/5GAG PDBsum 5GAH http://www.ebi.ac.uk/pdbsum/5GAH PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PROSITE PS00049 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00049 PSORT swissprot:RL14_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RL14_ECOLI PSORT-B swissprot:RL14_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RL14_ECOLI PSORT2 swissprot:RL14_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RL14_ECOLI Pfam PF00238 http://pfam.xfam.org/family/PF00238 Phobius swissprot:RL14_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RL14_ECOLI PhylomeDB P0ADY3 http://phylomedb.org/?seqid=P0ADY3 ProteinModelPortal P0ADY3 http://www.proteinmodelportal.org/query/uniprot/P0ADY3 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 10756104 http://www.ncbi.nlm.nih.gov/pubmed/10756104 PubMed 12809609 http://www.ncbi.nlm.nih.gov/pubmed/12809609 PubMed 151587 http://www.ncbi.nlm.nih.gov/pubmed/151587 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22829778 http://www.ncbi.nlm.nih.gov/pubmed/22829778 PubMed 24844575 http://www.ncbi.nlm.nih.gov/pubmed/24844575 PubMed 25310980 http://www.ncbi.nlm.nih.gov/pubmed/25310980 PubMed 2665813 http://www.ncbi.nlm.nih.gov/pubmed/2665813 PubMed 352727 http://www.ncbi.nlm.nih.gov/pubmed/352727 PubMed 6222285 http://www.ncbi.nlm.nih.gov/pubmed/6222285 PubMed 7556101 http://www.ncbi.nlm.nih.gov/pubmed/7556101 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417769 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417769 RefSeq WP_000613955 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000613955 SMART SM01374 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01374 SMR P0ADY3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADY3 STRING 511145.b3310 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3310&targetmode=cogs STRING COG0093 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0093&targetmode=cogs SUPFAM SSF50193 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50193 TIGRFAMs TIGR01067 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01067 UniProtKB RL14_ECOLI http://www.uniprot.org/uniprot/RL14_ECOLI UniProtKB-AC P0ADY3 http://www.uniprot.org/uniprot/P0ADY3 charge swissprot:RL14_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RL14_ECOLI eggNOG COG0093 http://eggnogapi.embl.de/nog_data/html/tree/COG0093 eggNOG ENOG4108UNN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UNN epestfind swissprot:RL14_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RL14_ECOLI garnier swissprot:RL14_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RL14_ECOLI helixturnhelix swissprot:RL14_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RL14_ECOLI hmoment swissprot:RL14_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RL14_ECOLI iep swissprot:RL14_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RL14_ECOLI inforesidue swissprot:RL14_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RL14_ECOLI octanol swissprot:RL14_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RL14_ECOLI pepcoil swissprot:RL14_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RL14_ECOLI pepdigest swissprot:RL14_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RL14_ECOLI pepinfo swissprot:RL14_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RL14_ECOLI pepnet swissprot:RL14_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RL14_ECOLI pepstats swissprot:RL14_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RL14_ECOLI pepwheel swissprot:RL14_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RL14_ECOLI pepwindow swissprot:RL14_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RL14_ECOLI sigcleave swissprot:RL14_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RL14_ECOLI ## Database ID URL or Descriptions # AltName Bifunctional [protein-PII] modification enzyme {ECO:0000255|HAMAP-Rule MF_00277} # AltName Bifunctional nitrogen sensor protein {ECO:0000255|HAMAP-Rule MF_00277} # AltName Bifunctional nitrogen sensor protein {ECO:0000255|HAMAP-Rule MF_00277} # BIOPHYSICOCHEMICAL PROPERTIES GLND_ECOLI Kinetic parameters KM=3.0 uM for GlnB protein {ECO 0000269|PubMed 9737855}; KM=40 uM for UTP {ECO 0000269|PubMed 9737855}; KM=2.3 uM for uridylyl-[protein-PII] (in the absence of glutamine) {ECO 0000269|PubMed 9737855}; KM=0.82 uM for uridylyl-[protein-PII] (in the presence of 2.5 mM glutamine) {ECO 0000269|PubMed 9737855}; Note=kcat is 137 min(-1) for the UTase reaction. kcat is 2.7 min(-1) for the UR reaction in the absence of glutamine, and 6.5 min(-1) in the presence of 2.5 mM glutamine.; # BRENDA 2.7.7.59 2026 # BioGrid 4259747 13 # CATALYTIC ACTIVITY UTP + [protein-PII] = diphosphate + uridylyl- [protein-PII]. {ECO:0000255|HAMAP-Rule MF_00277}. # CATALYTIC ACTIVITY Uridylyl-[protein-PII] + H(2)O = UMP + [protein-PII]. {ECO:0000255|HAMAP-Rule MF_00277}. # COFACTOR GLND_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_00277, ECO 0000269|PubMed 9737855}; Note=Mg(2+) appears to be the physiologically relevant metal ion cofactor for both transferase and uridylyl-removing activities. {ECO 0000255|HAMAP-Rule MF_00277, ECO 0000269|PubMed 9737855}; # DOMAIN GLND_ECOLI Has four distinct domains an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing. {ECO 0000255|HAMAP-Rule MF_00277, ECO 0000269|PubMed 20363937}. # ENZYME REGULATION GLND_ECOLI Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl- removing (UR) activity. Both reactions are activated by ATP and 2- ketoglutarate, via the binding of these effector molecules to the substrates PII and PII-UMP. {ECO 0000255|HAMAP-Rule MF_00277, ECO 0000269|PubMed 10231487, ECO 0000269|PubMed 20363937, ECO 0000269|PubMed 8843440, ECO 0000269|PubMed 9737855}. # EcoGene EG11411 glnD # FUNCTION GLND_ECOLI Modifies, by uridylylation and deuridylylation, the PII regulatory proteins GlnB and GlnK, in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. {ECO 0000269|PubMed 10231487, ECO 0000269|PubMed 20363937, ECO 0000269|PubMed 6130097, ECO 0000269|PubMed 8843440, ECO 0000269|PubMed 9737855}. # GO_function GO:0008081 phosphoric diester hydrolase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0008773 [protein-PII] uridylyltransferase activity; IDA:EcoCyc. # GO_function GO:0016597 amino acid binding; IEA:InterPro. # GO_process GO:0006464 cellular protein modification process; IDA:EcoCyc. # GO_process GO:0006807 nitrogen compound metabolic process; IEA:InterPro. # GO_process GO:0006808 regulation of nitrogen utilization; IEA:UniProtKB-HAMAP. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0008150 biological_process # Gene3D 1.10.3210.10 -; 1. # HAMAP MF_00277 PII_uridylyl_transf # INTERACTION GLND_ECOLI P0A9Z1 glnB; NbExp=3; IntAct=EBI-552032, EBI-551053; P0AC55 glnK; NbExp=3; IntAct=EBI-552032, EBI-559503; # IntAct P27249 24 # InterPro IPR002912 ACT_dom # InterPro IPR002934 Polymerase_NTP_transf_dom # InterPro IPR003607 HD/PDEase_dom # InterPro IPR006674 HD_domain # InterPro IPR010043 UTase/UR # InterPro IPR013546 PII_UdlTrfase/GS_AdlTrfase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko02020 Two-component system # MISCELLANEOUS The transferase reaction proceeds by an ordered bi- bi kinetic mechanism, with PII binding before UTP and pyrophosphate (PPi) released before PII-UMP. The uridylyl-removing reaction proceeds with rapid equilibrium binding of substrate and random release of products (PubMed:9737855). {ECO 0000305|PubMed:9737855}. # Organism GLND_ECOLI Escherichia coli (strain K12) # PATRIC 32115441 VBIEscCol129921_0172 # PIR G64740 G64740 # PIRSF PIRSF006288 PII_uridyltransf # PROSITE PS51671 ACT; 2 # Pfam PF01842 ACT; 2 # Pfam PF01909 NTP_transf_2 # Pfam PF01966 HD # Pfam PF08335 GlnD_UR_UTase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Bifunctional uridylyltransferase/uridylyl-removing enzyme {ECO:0000255|HAMAP-Rule MF_00277} # RecName [Protein-PII] uridylyltransferase {ECO:0000255|HAMAP-Rule MF_00277} # RecName [Protein-PII]-UMP uridylyl-removing enzyme {ECO:0000255|HAMAP-Rule MF_00277} # RefSeq NP_414709 NC_000913.3 # RefSeq WP_001094586 NZ_LN832404.1 # SIMILARITY Belongs to the GlnD family. {ECO:0000255|HAMAP- Rule MF_00277}. # SIMILARITY Contains 1 HD domain. {ECO:0000255|HAMAP- Rule MF_00277}. # SIMILARITY Contains 2 ACT domains. {ECO:0000255|HAMAP- Rule MF_00277}. # SMART SM00471 HDc # SUBUNIT Monomer. Can also form homooligomers that are much less active. {ECO:0000269|PubMed 6130097}. # TIGRFAMs TIGR01693 UTase_glnD # eggNOG COG2844 LUCA # eggNOG ENOG4105E1P Bacteria BLAST swissprot:GLND_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLND_ECOLI BioCyc ECOL316407:JW0162-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0162-MONOMER BioCyc EcoCyc:GLND-MONOMER http://biocyc.org/getid?id=EcoCyc:GLND-MONOMER BioCyc MetaCyc:GLND-MONOMER http://biocyc.org/getid?id=MetaCyc:GLND-MONOMER COG COG2844 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2844 DIP DIP-9779N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9779N DOI 10.1021/bi980667m http://dx.doi.org/10.1021/bi980667m DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1996.6281349.x http://dx.doi.org/10.1046/j.1365-2958.1996.6281349.x DOI 10.1046/j.1365-2958.1999.01349.x http://dx.doi.org/10.1046/j.1365-2958.1999.01349.x DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1111/j.1365-2958.1993.tb01706.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb01706.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01674-09 http://dx.doi.org/10.1128/JB.01674-09 EC_number EC:2.7.7.59 {ECO:0000255|HAMAP-Rule:MF_00277} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.59 {ECO:0000255|HAMAP-Rule:MF_00277} EC_number EC:3.1.4.- {ECO:0000255|HAMAP-Rule:MF_00277} http://www.genome.jp/dbget-bin/www_bget?EC:3.1.4.- {ECO:0000255|HAMAP-Rule:MF_00277} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M96431 http://www.ebi.ac.uk/ena/data/view/M96431 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EMBL Z21842 http://www.ebi.ac.uk/ena/data/view/Z21842 ENZYME 2.7.7.59 {ECO:0000255|HAMAP-Rule:MF_00277} http://enzyme.expasy.org/EC/2.7.7.59 {ECO:0000255|HAMAP-Rule:MF_00277} ENZYME 3.1.4.- {ECO:0000255|HAMAP-Rule:MF_00277} http://enzyme.expasy.org/EC/3.1.4.- {ECO:0000255|HAMAP-Rule:MF_00277} EchoBASE EB1383 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1383 EcoGene EG11411 http://www.ecogene.org/geneInfo.php?eg_id=EG11411 EnsemblBacteria AAC73278 http://www.ensemblgenomes.org/id/AAC73278 EnsemblBacteria AAC73278 http://www.ensemblgenomes.org/id/AAC73278 EnsemblBacteria BAE76045 http://www.ensemblgenomes.org/id/BAE76045 EnsemblBacteria BAE76045 http://www.ensemblgenomes.org/id/BAE76045 EnsemblBacteria BAE76045 http://www.ensemblgenomes.org/id/BAE76045 EnsemblBacteria b0167 http://www.ensemblgenomes.org/id/b0167 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008081 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008081 GO_function GO:0008773 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008773 GO_function GO:0016597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016597 GO_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GO_process GO:0006807 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006807 GO_process GO:0006808 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006808 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.10.3210.10 http://www.cathdb.info/version/latest/superfamily/1.10.3210.10 GeneID 944863 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944863 HAMAP MF_00277 http://hamap.expasy.org/unirule/MF_00277 HOGENOM HOG000261778 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261778&db=HOGENOM6 InParanoid P27249 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P27249 IntAct P27249 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P27249* IntEnz 2.7.7.59 {ECO:0000255|HAMAP-Rule:MF_00277} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.59 {ECO:0000255|HAMAP-Rule:MF_00277} IntEnz 3.1.4.- {ECO:0000255|HAMAP-Rule:MF_00277} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.4.- {ECO:0000255|HAMAP-Rule:MF_00277} InterPro IPR002912 http://www.ebi.ac.uk/interpro/entry/IPR002912 InterPro IPR002934 http://www.ebi.ac.uk/interpro/entry/IPR002934 InterPro IPR003607 http://www.ebi.ac.uk/interpro/entry/IPR003607 InterPro IPR006674 http://www.ebi.ac.uk/interpro/entry/IPR006674 InterPro IPR010043 http://www.ebi.ac.uk/interpro/entry/IPR010043 InterPro IPR013546 http://www.ebi.ac.uk/interpro/entry/IPR013546 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0162 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0162 KEGG_Gene eco:b0167 http://www.genome.jp/dbget-bin/www_bget?eco:b0167 KEGG_Orthology KO:K00990 http://www.genome.jp/dbget-bin/www_bget?KO:K00990 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 MINT MINT-1252261 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1252261 OMA ARICGYF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ARICGYF PROSITE PS51671 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51671 PSORT swissprot:GLND_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLND_ECOLI PSORT-B swissprot:GLND_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLND_ECOLI PSORT2 swissprot:GLND_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLND_ECOLI Pfam PF01842 http://pfam.xfam.org/family/PF01842 Pfam PF01909 http://pfam.xfam.org/family/PF01909 Pfam PF01966 http://pfam.xfam.org/family/PF01966 Pfam PF08335 http://pfam.xfam.org/family/PF08335 Phobius swissprot:GLND_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLND_ECOLI PhylomeDB P27249 http://phylomedb.org/?seqid=P27249 ProteinModelPortal P27249 http://www.proteinmodelportal.org/query/uniprot/P27249 PubMed 10231487 http://www.ncbi.nlm.nih.gov/pubmed/10231487 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20363937 http://www.ncbi.nlm.nih.gov/pubmed/20363937 PubMed 6130097 http://www.ncbi.nlm.nih.gov/pubmed/6130097 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 8412694 http://www.ncbi.nlm.nih.gov/pubmed/8412694 PubMed 8843440 http://www.ncbi.nlm.nih.gov/pubmed/8843440 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9737855 http://www.ncbi.nlm.nih.gov/pubmed/9737855 RefSeq NP_414709 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414709 RefSeq WP_001094586 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001094586 SMART SM00471 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00471 SMR P27249 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P27249 STRING 511145.b0167 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0167&targetmode=cogs STRING COG2844 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2844&targetmode=cogs TIGRFAMs TIGR01693 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01693 UniProtKB GLND_ECOLI http://www.uniprot.org/uniprot/GLND_ECOLI UniProtKB-AC P27249 http://www.uniprot.org/uniprot/P27249 charge swissprot:GLND_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLND_ECOLI eggNOG COG2844 http://eggnogapi.embl.de/nog_data/html/tree/COG2844 eggNOG ENOG4105E1P http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E1P epestfind swissprot:GLND_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLND_ECOLI garnier swissprot:GLND_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLND_ECOLI helixturnhelix swissprot:GLND_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLND_ECOLI hmoment swissprot:GLND_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLND_ECOLI iep swissprot:GLND_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLND_ECOLI inforesidue swissprot:GLND_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLND_ECOLI octanol swissprot:GLND_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLND_ECOLI pepcoil swissprot:GLND_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLND_ECOLI pepdigest swissprot:GLND_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLND_ECOLI pepinfo swissprot:GLND_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLND_ECOLI pepnet swissprot:GLND_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLND_ECOLI pepstats swissprot:GLND_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLND_ECOLI pepwheel swissprot:GLND_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLND_ECOLI pepwindow swissprot:GLND_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLND_ECOLI sigcleave swissprot:GLND_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLND_ECOLI ## Database ID URL or Descriptions # BioGrid 4259136 10 # EcoGene EG14011 ynjI # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR009677 DUF1266 # Organism YNJI_ECOLI Escherichia coli (strain K12) # PATRIC 32118835 VBIEscCol129921_1835 # PIR B64936 B64936 # Pfam PF06889 DUF1266 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNJI_ECOLI Inner membrane protein YnjI # RefSeq NP_416276 NC_000913.3 # RefSeq WP_000756910 NZ_LN832404.1 # SUBCELLULAR LOCATION YNJI_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG ENOG41065FB Bacteria # eggNOG ENOG4112A1H LUCA BLAST swissprot:YNJI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNJI_ECOLI BioCyc ECOL316407:JW5288-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5288-MONOMER BioCyc EcoCyc:G6956-MONOMER http://biocyc.org/getid?id=EcoCyc:G6956-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J05076 http://www.ebi.ac.uk/ena/data/view/J05076 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3767 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3767 EcoGene EG14011 http://www.ecogene.org/geneInfo.php?eg_id=EG14011 EnsemblBacteria AAC74832 http://www.ensemblgenomes.org/id/AAC74832 EnsemblBacteria AAC74832 http://www.ensemblgenomes.org/id/AAC74832 EnsemblBacteria BAE76524 http://www.ensemblgenomes.org/id/BAE76524 EnsemblBacteria BAE76524 http://www.ensemblgenomes.org/id/BAE76524 EnsemblBacteria BAE76524 http://www.ensemblgenomes.org/id/BAE76524 EnsemblBacteria b1762 http://www.ensemblgenomes.org/id/b1762 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 946239 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946239 HOGENOM HOG000009481 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009481&db=HOGENOM6 InterPro IPR009677 http://www.ebi.ac.uk/interpro/entry/IPR009677 KEGG_Gene ecj:JW5288 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5288 KEGG_Gene eco:b1762 http://www.genome.jp/dbget-bin/www_bget?eco:b1762 OMA SWMTSIS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SWMTSIS PSORT swissprot:YNJI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNJI_ECOLI PSORT-B swissprot:YNJI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNJI_ECOLI PSORT2 swissprot:YNJI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNJI_ECOLI Pfam PF06889 http://pfam.xfam.org/family/PF06889 Phobius swissprot:YNJI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNJI_ECOLI ProteinModelPortal P76228 http://www.proteinmodelportal.org/query/uniprot/P76228 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2553698 http://www.ncbi.nlm.nih.gov/pubmed/2553698 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416276 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416276 RefSeq WP_000756910 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000756910 STRING 511145.b1762 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1762&targetmode=cogs UniProtKB YNJI_ECOLI http://www.uniprot.org/uniprot/YNJI_ECOLI UniProtKB-AC P76228 http://www.uniprot.org/uniprot/P76228 charge swissprot:YNJI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNJI_ECOLI eggNOG ENOG41065FB http://eggnogapi.embl.de/nog_data/html/tree/ENOG41065FB eggNOG ENOG4112A1H http://eggnogapi.embl.de/nog_data/html/tree/ENOG4112A1H epestfind swissprot:YNJI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNJI_ECOLI garnier swissprot:YNJI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNJI_ECOLI helixturnhelix swissprot:YNJI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNJI_ECOLI hmoment swissprot:YNJI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNJI_ECOLI iep swissprot:YNJI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNJI_ECOLI inforesidue swissprot:YNJI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNJI_ECOLI octanol swissprot:YNJI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNJI_ECOLI pepcoil swissprot:YNJI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNJI_ECOLI pepdigest swissprot:YNJI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNJI_ECOLI pepinfo swissprot:YNJI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNJI_ECOLI pepnet swissprot:YNJI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNJI_ECOLI pepstats swissprot:YNJI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNJI_ECOLI pepwheel swissprot:YNJI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNJI_ECOLI pepwindow swissprot:YNJI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNJI_ECOLI sigcleave swissprot:YNJI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNJI_ECOLI ## Database ID URL or Descriptions # AltName Non-canonical purine NTP pyrophosphatase {ECO:0000255|HAMAP-Rule MF_01405} # AltName Non-standard purine NTP pyrophosphatase {ECO:0000255|HAMAP-Rule MF_01405} # AltName Nucleoside-triphosphate diphosphatase {ECO:0000255|HAMAP-Rule MF_01405} # AltName Nucleoside-triphosphate pyrophosphatase {ECO:0000255|HAMAP-Rule MF_01405} # AltName Nucleotide diphosphatase {ECO:0000255|HAMAP-Rule MF_01405} # BIOPHYSICOCHEMICAL PROPERTIES RDGB_ECOLI Kinetic parameters KM=0.33 mM for XTP {ECO 0000269|PubMed 12297000, ECO 0000269|PubMed 17090528}; KM=0.36 mM for dITP {ECO 0000269|PubMed 12297000, ECO 0000269|PubMed 17090528}; KM=0.41 mM for ITP {ECO 0000269|PubMed 12297000, ECO 0000269|PubMed 17090528}; KM=16.5 uM for dHAPTP {ECO 0000269|PubMed 12297000, ECO 0000269|PubMed 17090528}; Note=Vmax values are similar for XTP, dITP and ITP.; pH dependence Optimum pH is 10-10.5. {ECO 0000269|PubMed 12297000, ECO 0000269|PubMed 17090528}; # BRENDA 3.6.1.19 2026 # BioGrid 4260898 67 # BioGrid 851750 2 # CATALYTIC ACTIVITY RDGB_ECOLI A nucleoside triphosphate + H(2)O = a nucleotide + diphosphate. {ECO 0000255|HAMAP-Rule MF_01405, ECO 0000269|PubMed 12297000}. # CDD cd00515 HAM1 # COFACTOR RDGB_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 12297000}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 12297000}; Name=Ni(2+); Xref=ChEBI CHEBI 49786; Evidence={ECO 0000269|PubMed 12297000}; Note=Binds 1 divalent metal cation per subunit. Maximum activity is obtained with Mg(2+). Activity with Mn(2+) or Ni(2+) makes up 60-75% of the maximum rate. {ECO 0000269|PubMed 12297000}; # EcoGene EG12982 rdgB # FUNCTION RDGB_ECOLI Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides deoxyinosine triphosphate (dITP) and xanthosine triphosphate (XTP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) to their respective monophosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions. {ECO 0000255|HAMAP-Rule MF_01405, ECO 0000269|PubMed 17090528}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000166 nucleotide binding; IEA:UniProtKB-KW. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0017111 nucleoside-triphosphatase activity; IEA:InterPro. # GO_function GO:0035529 NADH pyrophosphatase activity; IEA:UniProtKB-EC. # GO_function GO:0047429 nucleoside-triphosphate diphosphatase activity; IDA:EcoCyc. # GO_process GO:0006163 purine nucleotide metabolic process; IEA:UniProtKB-HAMAP. # GO_process GO:0009143 nucleoside triphosphate catabolic process; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.90.950.10 -; 1. # HAMAP MF_01405 Non_canon_purine_NTPase # IntAct P52061 3 # InterPro IPR002637 Ham1p-like # InterPro IPR020922 NTPase # InterPro IPR029001 ITPase-like_fam # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00240 Pyrimidine metabolism # MISCELLANEOUS RDGB_ECOLI Activity toward dATP, dCTP and dTTP is less than 1% of the rate of XTP hydrolysis. Activity toward dGTP and dUTP is 10-12% lower than activity toward XTP. Modified or damaged nucleotides such as 6-chloropurine deoxyribose triphosphate, 8-Br- dGTP, 5-Br-dCTP, 5-Br-dUTP, 7-deaza-dGTP, 7-methyl-GTP, N6-etheno- ATP, NAD, NADH, FAD, ADP-ribose, UPD-glucose, AppA and ApppA are not hydrolyzed. # Organism RDGB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11067 PTHR11067 # PATRIC 32121320 VBIEscCol129921_3048 # PDB 1K7K X-ray; 1.50 A; A=1-197 # PDB 2PYU X-ray; 2.02 A; A=1-197 # PDB 2Q16 X-ray; 1.95 A; A/B=1-197 # PIR A65081 A65081 # Pfam PF01725 Ham1p_like # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName dITP/XTP pyrophosphatase {ECO:0000255|HAMAP-Rule MF_01405} # RefSeq NP_417429 NC_000913.3 # RefSeq WP_001174777 NZ_LN832404.1 # SIMILARITY Belongs to the HAM1 NTPase family. {ECO:0000255|HAMAP- Rule MF_01405}. # SUBUNIT RDGB_ECOLI Homodimer. {ECO 0000255|HAMAP-Rule MF_01405, ECO 0000269|PubMed 12297000}. # SUPFAM SSF52972 SSF52972 # TIGRFAMs TIGR00042 TIGR00042 # eggNOG COG0127 LUCA # eggNOG ENOG4108V82 Bacteria BLAST swissprot:RDGB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RDGB_ECOLI BioCyc ECOL316407:JW2921-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2921-MONOMER BioCyc EcoCyc:G7530-MONOMER http://biocyc.org/getid?id=EcoCyc:G7530-MONOMER BioCyc MetaCyc:G7530-MONOMER http://biocyc.org/getid?id=MetaCyc:G7530-MONOMER COG COG0127 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0127 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M608708200 http://dx.doi.org/10.1074/jbc.M608708200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.5483/BMBRep.2002.35.4.403 http://dx.doi.org/10.5483/BMBRep.2002.35.4.403 EC_number EC:3.6.1.9 {ECO:0000255|HAMAP-Rule:MF_01405} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.1.9 {ECO:0000255|HAMAP-Rule:MF_01405} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 ENZYME 3.6.1.9 {ECO:0000255|HAMAP-Rule:MF_01405} http://enzyme.expasy.org/EC/3.6.1.9 {ECO:0000255|HAMAP-Rule:MF_01405} EchoBASE EB2807 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2807 EcoGene EG12982 http://www.ecogene.org/geneInfo.php?eg_id=EG12982 EnsemblBacteria AAC75991 http://www.ensemblgenomes.org/id/AAC75991 EnsemblBacteria AAC75991 http://www.ensemblgenomes.org/id/AAC75991 EnsemblBacteria BAE77017 http://www.ensemblgenomes.org/id/BAE77017 EnsemblBacteria BAE77017 http://www.ensemblgenomes.org/id/BAE77017 EnsemblBacteria BAE77017 http://www.ensemblgenomes.org/id/BAE77017 EnsemblBacteria b2954 http://www.ensemblgenomes.org/id/b2954 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000166 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000166 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0017111 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017111 GO_function GO:0035529 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035529 GO_function GO:0047429 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047429 GO_process GO:0006163 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006163 GO_process GO:0009143 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009143 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.90.950.10 http://www.cathdb.info/version/latest/superfamily/3.90.950.10 GeneID 947429 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947429 HAMAP MF_01405 http://hamap.expasy.org/unirule/MF_01405 HOGENOM HOG000293319 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000293319&db=HOGENOM6 InParanoid P52061 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P52061 IntAct P52061 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P52061* IntEnz 3.6.1.9 {ECO:0000255|HAMAP-Rule:MF_01405} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.1.9 {ECO:0000255|HAMAP-Rule:MF_01405} InterPro IPR002637 http://www.ebi.ac.uk/interpro/entry/IPR002637 InterPro IPR020922 http://www.ebi.ac.uk/interpro/entry/IPR020922 InterPro IPR029001 http://www.ebi.ac.uk/interpro/entry/IPR029001 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2921 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2921 KEGG_Gene eco:b2954 http://www.genome.jp/dbget-bin/www_bget?eco:b2954 KEGG_Orthology KO:K02428 http://www.genome.jp/dbget-bin/www_bget?KO:K02428 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Reaction rn:R00426 http://www.genome.jp/dbget-bin/www_bget?rn:R00426 KEGG_Reaction rn:R00662 http://www.genome.jp/dbget-bin/www_bget?rn:R00662 KEGG_Reaction rn:R00720 http://www.genome.jp/dbget-bin/www_bget?rn:R00720 KEGG_Reaction rn:R01855 http://www.genome.jp/dbget-bin/www_bget?rn:R01855 KEGG_Reaction rn:R02100 http://www.genome.jp/dbget-bin/www_bget?rn:R02100 KEGG_Reaction rn:R02720 http://www.genome.jp/dbget-bin/www_bget?rn:R02720 KEGG_Reaction rn:R03531 http://www.genome.jp/dbget-bin/www_bget?rn:R03531 MINT MINT-1322479 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1322479 OMA CEGLWHG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CEGLWHG PANTHER PTHR11067 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11067 PDB 1K7K http://www.ebi.ac.uk/pdbe-srv/view/entry/1K7K PDB 2PYU http://www.ebi.ac.uk/pdbe-srv/view/entry/2PYU PDB 2Q16 http://www.ebi.ac.uk/pdbe-srv/view/entry/2Q16 PDBsum 1K7K http://www.ebi.ac.uk/pdbsum/1K7K PDBsum 2PYU http://www.ebi.ac.uk/pdbsum/2PYU PDBsum 2Q16 http://www.ebi.ac.uk/pdbsum/2Q16 PSORT swissprot:RDGB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RDGB_ECOLI PSORT-B swissprot:RDGB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RDGB_ECOLI PSORT2 swissprot:RDGB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RDGB_ECOLI Pfam PF01725 http://pfam.xfam.org/family/PF01725 Phobius swissprot:RDGB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RDGB_ECOLI PhylomeDB P52061 http://phylomedb.org/?seqid=P52061 ProteinModelPortal P52061 http://www.proteinmodelportal.org/query/uniprot/P52061 PubMed 12297000 http://www.ncbi.nlm.nih.gov/pubmed/12297000 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17090528 http://www.ncbi.nlm.nih.gov/pubmed/17090528 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417429 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417429 RefSeq WP_001174777 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001174777 SMR P52061 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P52061 STRING 511145.b2954 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2954&targetmode=cogs STRING COG0127 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0127&targetmode=cogs SUPFAM SSF52972 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52972 TIGRFAMs TIGR00042 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00042 UniProtKB RDGB_ECOLI http://www.uniprot.org/uniprot/RDGB_ECOLI UniProtKB-AC P52061 http://www.uniprot.org/uniprot/P52061 charge swissprot:RDGB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RDGB_ECOLI eggNOG COG0127 http://eggnogapi.embl.de/nog_data/html/tree/COG0127 eggNOG ENOG4108V82 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108V82 epestfind swissprot:RDGB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RDGB_ECOLI garnier swissprot:RDGB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RDGB_ECOLI helixturnhelix swissprot:RDGB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RDGB_ECOLI hmoment swissprot:RDGB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RDGB_ECOLI iep swissprot:RDGB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RDGB_ECOLI inforesidue swissprot:RDGB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RDGB_ECOLI octanol swissprot:RDGB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RDGB_ECOLI pepcoil swissprot:RDGB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RDGB_ECOLI pepdigest swissprot:RDGB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RDGB_ECOLI pepinfo swissprot:RDGB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RDGB_ECOLI pepnet swissprot:RDGB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RDGB_ECOLI pepstats swissprot:RDGB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RDGB_ECOLI pepwheel swissprot:RDGB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RDGB_ECOLI pepwindow swissprot:RDGB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RDGB_ECOLI sigcleave swissprot:RDGB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RDGB_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES NAGD_ECOLI Kinetic parameters KM=160 uM for UMP (at pH 7 and at 25 degrees Celsius) {ECO 0000269|PubMed 16430214}; KM=400 uM for GMP (at pH 7 and at 25 degrees Celsius) {ECO 0000269|PubMed 16430214}; KM=840 uM for AMP (at pH 7 and at 25 degrees Celsius) {ECO 0000269|PubMed 16430214}; KM=840 uM for ribose-5-phosphate (at pH 7 and at 25 degrees Celsius) {ECO 0000269|PubMed 16430214}; KM=1470 uM for CMP (at pH 7 and at 25 degrees Celsius) {ECO 0000269|PubMed 16430214}; KM=1500 uM for dTMP (at pH 7 and at 25 degrees Celsius) {ECO 0000269|PubMed 16430214}; KM=1500 uM for pyridoxal 5-phosphate (at pH 7 and at 25 degrees Celsius) {ECO 0000269|PubMed 16430214}; KM=1700 uM for glycerol 3-phosphate (at pH 7 and at 25 degrees Celsius) {ECO 0000269|PubMed 16430214}; KM=5900 uM for glucose 6-phosphate (at pH 7 and at 25 degrees Celsius) {ECO 0000269|PubMed 16430214}; KM=6000 uM for glucosamine 6-phosphate (at pH 7 and at 25 degrees Celsius) {ECO 0000269|PubMed 16430214}; KM=6000 uM for dCMP (at pH 7 and at 25 degrees Celsius) {ECO 0000269|PubMed 16430214}; KM=6500 uM for dAMP (at pH 7 and at 25 degrees Celsius) {ECO 0000269|PubMed 16430214}; KM=7600 uM for dGMP (at pH 7 and at 25 degrees Celsius) {ECO 0000269|PubMed 16430214}; KM=7700 uM for dGMP (at pH 7 and at 25 degrees Celsius) {ECO 0000269|PubMed 16430214}; # BioGrid 4259613 9 # CATALYTIC ACTIVITY NAGD_ECOLI A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate. # COFACTOR NAGD_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 16430214, ECO 0000269|PubMed 16990279}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 16430214, ECO 0000269|PubMed 16990279}; Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000269|PubMed 16430214, ECO 0000269|PubMed 16990279}; Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 16430214, ECO 0000269|PubMed 16990279}; Note=Magnesium. Can also use other divalent metal cations as manganese, cobalt or zinc. {ECO 0000269|PubMed 16430214, ECO 0000269|PubMed 16990279}; # EcoGene EG10634 nagD # FUNCTION NAGD_ECOLI Catalyzes the dephosphorylation of an unusually broad range of substrate including deoxyribo- and ribonucleoside tri-, di-, and monophosphates, as well as polyphosphate and glucose-1-P (Glu1P). {ECO 0000269|PubMed 16430214, ECO 0000269|PubMed 16990279}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IDA:UniProtKB. # GO_function GO:0008253 5'-nucleotidase activity; IDA:UniProtKB. # GO_process GO:0005975 carbohydrate metabolic process; IEA:UniProtKB-KW. # GO_process GO:0046050 UMP catabolic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.1000 -; 2. # Gene3D 3.40.50.10410 -; 1. # INDUCTION By N-acetylglucosamine. {ECO 0000305}. # IntAct P0AF24 4 # InterPro IPR006357 HAD-SF_hydro_IIA # InterPro IPR023214 HAD-like_dom # InterPro IPR023215 NPhePase-like_dom # Organism NAGD_ECOLI Escherichia coli (strain K12) # PATRIC 32116535 VBIEscCol129921_0700 # PDB 2C4N X-ray; 1.80 A; A=1-250 # PIR B64802 B64802 # Pfam PF13344 Hydrolase_6 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NAGD_ECOLI Ribonucleotide monophosphatase NagD # RefSeq NP_415201 NC_000913.3 # RefSeq WP_000153129 NZ_LN832404.1 # RefSeq WP_000153136 NZ_CP014272.1 # SIMILARITY Belongs to the HAD-like hydrolase superfamily. NagD family. {ECO 0000305}. # SUBUNIT Monomer. {ECO:0000269|PubMed 16430214}. # SUPFAM SSF56784 SSF56784 # TIGRFAMs TIGR01460 HAD-SF-IIA # eggNOG COG0647 LUCA # eggNOG ENOG4105D4U Bacteria BLAST swissprot:NAGD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NAGD_ECOLI BioCyc ECOL316407:JW0661-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0661-MONOMER BioCyc EcoCyc:EG10634-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10634-MONOMER BioCyc MetaCyc:EG10634-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10634-MONOMER COG COG0647 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0647 DIP DIP-6861N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-6861N DOI 10.1021/bi051842j http://dx.doi.org/10.1021/bi051842j DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M605449200 http://dx.doi.org/10.1074/jbc.M605449200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1989.tb00197.x http://dx.doi.org/10.1111/j.1365-2958.1989.tb00197.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.3.5 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.5 EMBL AF052007 http://www.ebi.ac.uk/ena/data/view/AF052007 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X14135 http://www.ebi.ac.uk/ena/data/view/X14135 ENZYME 3.1.3.5 http://enzyme.expasy.org/EC/3.1.3.5 EchoBASE EB0628 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0628 EcoGene EG10634 http://www.ecogene.org/geneInfo.php?eg_id=EG10634 EnsemblBacteria AAC73769 http://www.ensemblgenomes.org/id/AAC73769 EnsemblBacteria AAC73769 http://www.ensemblgenomes.org/id/AAC73769 EnsemblBacteria BAA35318 http://www.ensemblgenomes.org/id/BAA35318 EnsemblBacteria BAA35318 http://www.ensemblgenomes.org/id/BAA35318 EnsemblBacteria BAA35318 http://www.ensemblgenomes.org/id/BAA35318 EnsemblBacteria b0675 http://www.ensemblgenomes.org/id/b0675 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0008253 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008253 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GO_process GO:0046050 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046050 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.1000 http://www.cathdb.info/version/latest/superfamily/3.40.50.1000 Gene3D 3.40.50.10410 http://www.cathdb.info/version/latest/superfamily/3.40.50.10410 GeneID 945283 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945283 HOGENOM HOG000068105 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000068105&db=HOGENOM6 InParanoid P0AF24 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AF24 IntAct P0AF24 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AF24* IntEnz 3.1.3.5 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.5 InterPro IPR006357 http://www.ebi.ac.uk/interpro/entry/IPR006357 InterPro IPR023214 http://www.ebi.ac.uk/interpro/entry/IPR023214 InterPro IPR023215 http://www.ebi.ac.uk/interpro/entry/IPR023215 KEGG_Gene ecj:JW0661 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0661 KEGG_Gene eco:b0675 http://www.genome.jp/dbget-bin/www_bget?eco:b0675 KEGG_Orthology KO:K02566 http://www.genome.jp/dbget-bin/www_bget?KO:K02566 OMA HSETSAM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HSETSAM PDB 2C4N http://www.ebi.ac.uk/pdbe-srv/view/entry/2C4N PDBsum 2C4N http://www.ebi.ac.uk/pdbsum/2C4N PSORT swissprot:NAGD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NAGD_ECOLI PSORT-B swissprot:NAGD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NAGD_ECOLI PSORT2 swissprot:NAGD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NAGD_ECOLI Pfam PF13344 http://pfam.xfam.org/family/PF13344 Phobius swissprot:NAGD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NAGD_ECOLI PhylomeDB P0AF24 http://phylomedb.org/?seqid=P0AF24 ProteinModelPortal P0AF24 http://www.proteinmodelportal.org/query/uniprot/P0AF24 PubMed 16430214 http://www.ncbi.nlm.nih.gov/pubmed/16430214 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16990279 http://www.ncbi.nlm.nih.gov/pubmed/16990279 PubMed 2190615 http://www.ncbi.nlm.nih.gov/pubmed/2190615 PubMed 2668691 http://www.ncbi.nlm.nih.gov/pubmed/2668691 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415201 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415201 RefSeq WP_000153129 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000153129 RefSeq WP_000153136 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000153136 SMR P0AF24 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AF24 STRING 511145.b0675 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0675&targetmode=cogs STRING COG0647 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0647&targetmode=cogs SUPFAM SSF56784 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784 TIGRFAMs TIGR01460 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01460 UniProtKB NAGD_ECOLI http://www.uniprot.org/uniprot/NAGD_ECOLI UniProtKB-AC P0AF24 http://www.uniprot.org/uniprot/P0AF24 charge swissprot:NAGD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NAGD_ECOLI eggNOG COG0647 http://eggnogapi.embl.de/nog_data/html/tree/COG0647 eggNOG ENOG4105D4U http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D4U epestfind swissprot:NAGD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NAGD_ECOLI garnier swissprot:NAGD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NAGD_ECOLI helixturnhelix swissprot:NAGD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NAGD_ECOLI hmoment swissprot:NAGD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NAGD_ECOLI iep swissprot:NAGD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NAGD_ECOLI inforesidue swissprot:NAGD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NAGD_ECOLI octanol swissprot:NAGD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NAGD_ECOLI pepcoil swissprot:NAGD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NAGD_ECOLI pepdigest swissprot:NAGD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NAGD_ECOLI pepinfo swissprot:NAGD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NAGD_ECOLI pepnet swissprot:NAGD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NAGD_ECOLI pepstats swissprot:NAGD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NAGD_ECOLI pepwheel swissprot:NAGD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NAGD_ECOLI pepwindow swissprot:NAGD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NAGD_ECOLI sigcleave swissprot:NAGD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NAGD_ECOLI ## Database ID URL or Descriptions # AltName RSMC_ECOLI 16S rRNA m2G1207 methyltransferase # AltName RSMC_ECOLI rRNA (guanine-N(2)-)-methyltransferase RsmC # BRENDA 2.1.1.172 2026 # BioGrid 4262778 9 # CATALYTIC ACTIVITY RSMC_ECOLI S-adenosyl-L-methionine + guanine(1207) in 16S rRNA = S-adenosyl-L-homocysteine + N(2)-methylguanine(1207) in 16S rRNA. # COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI 18420; # EcoGene EG12596 rsmC # FUNCTION RSMC_ECOLI Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle. # GO_component GO:0005737 cytoplasm; IC:UniProtKB. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003676 nucleic acid binding; IEA:InterPro. # GO_function GO:0008990 rRNA (guanine-N2-)-methyltransferase activity; IDA:UniProtKB. # GO_function GO:0052914 16S rRNA (guanine(1207)-N(2))-methyltransferase activity; IDA:EcoCyc. # GO_process GO:0031167 rRNA methylation; IDA:UniProtKB. # GO_process GO:0070475 rRNA base methylation; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.50.150 -; 1. # HAMAP MF_01862 16SrRNA_methyltr_C # IntAct P39406 14 # InterPro IPR002052 DNA_methylase_N6_adenine_CS # InterPro IPR007848 Small_mtfrase_dom # InterPro IPR013675 Mtase_sm_N # InterPro IPR023543 rRNA_ssu_MeTfrase_C # InterPro IPR029063 SAM-dependent_MTases # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # Organism RSMC_ECOLI Escherichia coli (strain K12) # PATRIC 32124352 VBIEscCol129921_4516 # PDB 2PJD X-ray; 2.10 A; A=1-343 # PIR S56595 S56595 # Pfam PF05175 MTS # Pfam PF08468 MTS_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RSMC_ECOLI Ribosomal RNA small subunit methyltransferase C # RefSeq NP_418788 NC_000913.3 # RefSeq WP_001272330 NZ_LN832404.1 # SIMILARITY Belongs to the methyltransferase superfamily. RsmC family. {ECO 0000305}. # SUBCELLULAR LOCATION RSMC_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Monomer. {ECO:0000269|PubMed 17576679}. # SUPFAM SSF53335 SSF53335 # eggNOG COG2813 LUCA # eggNOG ENOG4105D8J Bacteria BLAST swissprot:RSMC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RSMC_ECOLI BioCyc ECOL316407:JW4333-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4333-MONOMER BioCyc EcoCyc:G7950-MONOMER http://biocyc.org/getid?id=EcoCyc:G7950-MONOMER BioCyc MetaCyc:G7950-MONOMER http://biocyc.org/getid?id=MetaCyc:G7950-MONOMER COG COG2813 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2813 DIP DIP-10804N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10804N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.274.2.924 http://dx.doi.org/10.1074/jbc.274.2.924 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1093/nar/gkm411 http://dx.doi.org/10.1093/nar/gkm411 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.1.172 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.172 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 2.1.1.172 http://enzyme.expasy.org/EC/2.1.1.172 EchoBASE EB2481 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2481 EcoGene EG12596 http://www.ecogene.org/geneInfo.php?eg_id=EG12596 EnsemblBacteria AAC77324 http://www.ensemblgenomes.org/id/AAC77324 EnsemblBacteria AAC77324 http://www.ensemblgenomes.org/id/AAC77324 EnsemblBacteria BAE78359 http://www.ensemblgenomes.org/id/BAE78359 EnsemblBacteria BAE78359 http://www.ensemblgenomes.org/id/BAE78359 EnsemblBacteria BAE78359 http://www.ensemblgenomes.org/id/BAE78359 EnsemblBacteria b4371 http://www.ensemblgenomes.org/id/b4371 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003676 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003676 GO_function GO:0008990 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008990 GO_function GO:0052914 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052914 GO_process GO:0031167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031167 GO_process GO:0070475 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070475 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 GeneID 948892 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948892 HAMAP MF_01862 http://hamap.expasy.org/unirule/MF_01862 HOGENOM HOG000218308 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218308&db=HOGENOM6 InParanoid P39406 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39406 IntAct P39406 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39406* IntEnz 2.1.1.172 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.172 InterPro IPR002052 http://www.ebi.ac.uk/interpro/entry/IPR002052 InterPro IPR007848 http://www.ebi.ac.uk/interpro/entry/IPR007848 InterPro IPR013675 http://www.ebi.ac.uk/interpro/entry/IPR013675 InterPro IPR023543 http://www.ebi.ac.uk/interpro/entry/IPR023543 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW4333 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4333 KEGG_Gene eco:b4371 http://www.genome.jp/dbget-bin/www_bget?eco:b4371 KEGG_Orthology KO:K00564 http://www.genome.jp/dbget-bin/www_bget?KO:K00564 KEGG_Reaction rn:R07234 http://www.genome.jp/dbget-bin/www_bget?rn:R07234 OMA RHCQLWQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RHCQLWQ PDB 2PJD http://www.ebi.ac.uk/pdbe-srv/view/entry/2PJD PDBsum 2PJD http://www.ebi.ac.uk/pdbsum/2PJD PSORT swissprot:RSMC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RSMC_ECOLI PSORT-B swissprot:RSMC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RSMC_ECOLI PSORT2 swissprot:RSMC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RSMC_ECOLI Pfam PF05175 http://pfam.xfam.org/family/PF05175 Pfam PF08468 http://pfam.xfam.org/family/PF08468 Phobius swissprot:RSMC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RSMC_ECOLI PhylomeDB P39406 http://phylomedb.org/?seqid=P39406 ProteinModelPortal P39406 http://www.proteinmodelportal.org/query/uniprot/P39406 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17576679 http://www.ncbi.nlm.nih.gov/pubmed/17576679 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9873033 http://www.ncbi.nlm.nih.gov/pubmed/9873033 RefSeq NP_418788 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418788 RefSeq WP_001272330 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001272330 SMR P39406 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39406 STRING 511145.b4371 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4371&targetmode=cogs STRING COG2813 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2813&targetmode=cogs SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 UniProtKB RSMC_ECOLI http://www.uniprot.org/uniprot/RSMC_ECOLI UniProtKB-AC P39406 http://www.uniprot.org/uniprot/P39406 charge swissprot:RSMC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RSMC_ECOLI eggNOG COG2813 http://eggnogapi.embl.de/nog_data/html/tree/COG2813 eggNOG ENOG4105D8J http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D8J epestfind swissprot:RSMC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RSMC_ECOLI garnier swissprot:RSMC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RSMC_ECOLI helixturnhelix swissprot:RSMC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RSMC_ECOLI hmoment swissprot:RSMC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RSMC_ECOLI iep swissprot:RSMC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RSMC_ECOLI inforesidue swissprot:RSMC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RSMC_ECOLI octanol swissprot:RSMC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RSMC_ECOLI pepcoil swissprot:RSMC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RSMC_ECOLI pepdigest swissprot:RSMC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RSMC_ECOLI pepinfo swissprot:RSMC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RSMC_ECOLI pepnet swissprot:RSMC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RSMC_ECOLI pepstats swissprot:RSMC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RSMC_ECOLI pepwheel swissprot:RSMC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RSMC_ECOLI pepwindow swissprot:RSMC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RSMC_ECOLI sigcleave swissprot:RSMC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RSMC_ECOLI ## Database ID URL or Descriptions # BioGrid 4261104 15 # CDD cd01949 GGDEF # EcoGene EG13477 yliF # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR000160 GGDEF_dom # InterPro IPR029787 Nucleotide_cyclase # InterPro IPR033422 GAPES2 # Organism YLIF_ECOLI Escherichia coli (strain K12) # PATRIC 32116871 VBIEscCol129921_0861 # PIR B64821 B64821 # PROSITE PS50887 GGDEF # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF00990 GGDEF # Pfam PF17156 GAPES2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YLIF_ECOLI Putative lipoprotein YliF # RefSeq NP_415355 NC_000913.3 # RefSeq WP_000086904 NZ_LN832404.1 # SIMILARITY Contains 1 GGDEF domain. {ECO:0000255|PROSITE- ProRule PRU00095}. # SMART SM00267 GGDEF # SUBCELLULAR LOCATION YLIF_ECOLI Cell membrane {ECO 0000255|PROSITE- ProRule PRU00303}; Single-pass membrane protein {ECO 0000305}. # SUPFAM SSF55073 SSF55073 # TIGRFAMs TIGR00254 GGDEF # eggNOG COG2199 LUCA # eggNOG ENOG41064RH Bacteria BLAST swissprot:YLIF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YLIF_ECOLI BioCyc ECOL316407:JW0818-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0818-MONOMER BioCyc EcoCyc:G6434-MONOMER http://biocyc.org/getid?id=EcoCyc:G6434-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3250 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3250 EcoGene EG13477 http://www.ecogene.org/geneInfo.php?eg_id=EG13477 EnsemblBacteria AAC73921 http://www.ensemblgenomes.org/id/AAC73921 EnsemblBacteria AAC73921 http://www.ensemblgenomes.org/id/AAC73921 EnsemblBacteria BAA35529 http://www.ensemblgenomes.org/id/BAA35529 EnsemblBacteria BAA35529 http://www.ensemblgenomes.org/id/BAA35529 EnsemblBacteria BAA35529 http://www.ensemblgenomes.org/id/BAA35529 EnsemblBacteria b0834 http://www.ensemblgenomes.org/id/b0834 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 945463 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945463 HOGENOM HOG000118183 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118183&db=HOGENOM6 InterPro IPR000160 http://www.ebi.ac.uk/interpro/entry/IPR000160 InterPro IPR029787 http://www.ebi.ac.uk/interpro/entry/IPR029787 InterPro IPR033422 http://www.ebi.ac.uk/interpro/entry/IPR033422 KEGG_Gene ecj:JW0818 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0818 KEGG_Gene eco:b0834 http://www.genome.jp/dbget-bin/www_bget?eco:b0834 OMA EKGSYLC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EKGSYLC PROSITE PS50887 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50887 PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YLIF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YLIF_ECOLI PSORT-B swissprot:YLIF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YLIF_ECOLI PSORT2 swissprot:YLIF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YLIF_ECOLI Pfam PF00990 http://pfam.xfam.org/family/PF00990 Pfam PF17156 http://pfam.xfam.org/family/PF17156 Phobius swissprot:YLIF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YLIF_ECOLI PhylomeDB P75801 http://phylomedb.org/?seqid=P75801 ProteinModelPortal P75801 http://www.proteinmodelportal.org/query/uniprot/P75801 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415355 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415355 RefSeq WP_000086904 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000086904 SMART SM00267 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00267 SMR P75801 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75801 STRING 511145.b0834 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0834&targetmode=cogs SUPFAM SSF55073 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55073 TIGRFAMs TIGR00254 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00254 UniProtKB YLIF_ECOLI http://www.uniprot.org/uniprot/YLIF_ECOLI UniProtKB-AC P75801 http://www.uniprot.org/uniprot/P75801 charge swissprot:YLIF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YLIF_ECOLI eggNOG COG2199 http://eggnogapi.embl.de/nog_data/html/tree/COG2199 eggNOG ENOG41064RH http://eggnogapi.embl.de/nog_data/html/tree/ENOG41064RH epestfind swissprot:YLIF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YLIF_ECOLI garnier swissprot:YLIF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YLIF_ECOLI helixturnhelix swissprot:YLIF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YLIF_ECOLI hmoment swissprot:YLIF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YLIF_ECOLI iep swissprot:YLIF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YLIF_ECOLI inforesidue swissprot:YLIF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YLIF_ECOLI octanol swissprot:YLIF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YLIF_ECOLI pepcoil swissprot:YLIF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YLIF_ECOLI pepdigest swissprot:YLIF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YLIF_ECOLI pepinfo swissprot:YLIF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YLIF_ECOLI pepnet swissprot:YLIF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YLIF_ECOLI pepstats swissprot:YLIF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YLIF_ECOLI pepwheel swissprot:YLIF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YLIF_ECOLI pepwindow swissprot:YLIF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YLIF_ECOLI sigcleave swissprot:YLIF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YLIF_ECOLI ## Database ID URL or Descriptions # EcoGene EG14413 yceQ # InterPro IPR020371 Uncharacterised_YceQ # Organism YCEQ_ECOLI Escherichia coli (strain K12) # PIR B64852 B64852 # Pfam PF10848 DUF2655 # ProDom PD078424 Uncharacterised_YceQ # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCEQ_ECOLI Uncharacterized protein YceQ # RefSeq NP_415603 NC_000913.3 # RefSeq WP_001295962 NZ_LN832404.1 # eggNOG ENOG41071G1 Bacteria # eggNOG ENOG410YYPH LUCA BLAST swissprot:YCEQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCEQ_ECOLI BioCyc ECOL316407:JW5154-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5154-MONOMER BioCyc EcoCyc:G6563-MONOMER http://biocyc.org/getid?id=EcoCyc:G6563-MONOMER DIP DIP-28073N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-28073N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4308 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4308 EcoGene EG14413 http://www.ecogene.org/geneInfo.php?eg_id=EG14413 EnsemblBacteria AAC74169 http://www.ensemblgenomes.org/id/AAC74169 EnsemblBacteria AAC74169 http://www.ensemblgenomes.org/id/AAC74169 EnsemblBacteria BAE76373 http://www.ensemblgenomes.org/id/BAE76373 EnsemblBacteria BAE76373 http://www.ensemblgenomes.org/id/BAE76373 EnsemblBacteria BAE76373 http://www.ensemblgenomes.org/id/BAE76373 EnsemblBacteria b1085 http://www.ensemblgenomes.org/id/b1085 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945640 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945640 HOGENOM HOG000119041 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000119041&db=HOGENOM6 IntAct P62066 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P62066* InterPro IPR020371 http://www.ebi.ac.uk/interpro/entry/IPR020371 KEGG_Gene ecj:JW5154 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5154 KEGG_Gene eco:b1085 http://www.genome.jp/dbget-bin/www_bget?eco:b1085 OMA CXPCYSK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CXPCYSK PSORT swissprot:YCEQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCEQ_ECOLI PSORT-B swissprot:YCEQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCEQ_ECOLI PSORT2 swissprot:YCEQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCEQ_ECOLI Pfam PF10848 http://pfam.xfam.org/family/PF10848 Phobius swissprot:YCEQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCEQ_ECOLI ProteinModelPortal P62066 http://www.proteinmodelportal.org/query/uniprot/P62066 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415603 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415603 RefSeq WP_001295962 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295962 STRING 511145.b1085 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1085&targetmode=cogs UniProtKB YCEQ_ECOLI http://www.uniprot.org/uniprot/YCEQ_ECOLI UniProtKB-AC P62066 http://www.uniprot.org/uniprot/P62066 charge swissprot:YCEQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCEQ_ECOLI eggNOG ENOG41071G1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41071G1 eggNOG ENOG410YYPH http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YYPH epestfind swissprot:YCEQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCEQ_ECOLI garnier swissprot:YCEQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCEQ_ECOLI helixturnhelix swissprot:YCEQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCEQ_ECOLI hmoment swissprot:YCEQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCEQ_ECOLI iep swissprot:YCEQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCEQ_ECOLI inforesidue swissprot:YCEQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCEQ_ECOLI octanol swissprot:YCEQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCEQ_ECOLI pepcoil swissprot:YCEQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCEQ_ECOLI pepdigest swissprot:YCEQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCEQ_ECOLI pepinfo swissprot:YCEQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCEQ_ECOLI pepnet swissprot:YCEQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCEQ_ECOLI pepstats swissprot:YCEQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCEQ_ECOLI pepwheel swissprot:YCEQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCEQ_ECOLI pepwindow swissprot:YCEQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCEQ_ECOLI sigcleave swissprot:YCEQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCEQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4262617 325 # DISRUPTION PHENOTYPE Disruption blocks the export of seven endogenous Tat substrates. {ECO:0000269|PubMed 10593889}. # DOMAIN TATB_ECOLI The membrane-extrinsic domain forms parallel contacts with at least one other TatB protein. {ECO 0000269|PubMed 21237157}. # EcoGene EG14322 tatB # FUNCTION TATB_ECOLI Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation. {ECO 0000255|HAMAP- Rule MF_00237, ECO 0000269|PubMed 10593889, ECO 0000269|PubMed 11922668, ECO 0000269|PubMed 14580344, ECO 0000269|PubMed 19666509, ECO 0000269|PubMed 20926683}. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0033281 TAT protein transport complex; IDA:EcoCyc. # GO_function GO:0009977 proton motive force dependent protein transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0009306 protein secretion; IEA:InterPro. # GO_process GO:0043953 protein transport by the Tat complex; IDA:EcoCyc. # GO_process GO:0065002 intracellular protein transmembrane transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005622 intracellular # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008565 protein transporter activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # HAMAP MF_00237 TatB # INDUCTION Constitutively expressed. {ECO:0000269|PubMed 11160116}. # INTERACTION TATB_ECOLI Self; NbExp=3; IntAct=EBI-4411577, EBI-4411577; P69423 tatC; NbExp=3; IntAct=EBI-4411577, EBI-4411641; # IntAct P69425 4 # InterPro IPR003998 TatB-like # InterPro IPR018448 TatB # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02044 M00336 Twin-arginine translocation (Tat) system # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko03060 Protein export # KEGG_Pathway ko03070 Bacterial secretion system # Organism TATB_ECOLI Escherichia coli (strain K12) # PATRIC 32123175 VBIEscCol129921_3953 # PIR G91224 G91224 # PRINTS PR01506 TATBPROTEIN # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Sec-independent protein translocase protein TatB {ECO:0000255|HAMAP-Rule MF_00237} # RefSeq WP_000459594 NZ_LN832404.1 # RefSeq YP_026270 NC_000913.3 # SIMILARITY Belongs to the TatB family. {ECO:0000255|HAMAP- Rule MF_00237}. # SUBCELLULAR LOCATION TATB_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_00237, ECO 0000269|PubMed 11591389, ECO 0000269|PubMed 15225613, ECO 0000269|PubMed 20169075}; Single- pass membrane protein {ECO 0000255|HAMAP-Rule MF_00237, ECO 0000269|PubMed 11591389, ECO 0000269|PubMed 15225613, ECO 0000269|PubMed 20169075}. Note=Localizes at the cell poles. # SUBUNIT TATB_ECOLI The Tat system comprises two distinct complexes a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon. A complex containing only TatA and TatB has also been identified. It could be either an assembly intermediate or a disassembly intermediate generated during translocation activity. Each of TatA, TatB and TatC are able to interact in pairs without the third partner; TatB also forms homooligomers. Interacts with the signal sequence of DmsA and DmsD. {ECO 0000255|HAMAP-Rule MF_00237, ECO 0000269|PubMed 11279240, ECO 0000269|PubMed 11422364, ECO 0000269|PubMed 15225613, ECO 0000269|PubMed 15571732, ECO 0000269|PubMed 15663945, ECO 0000269|PubMed 17686475, ECO 0000269|PubMed 20169075}. # TCDB 2.A.64.1 the twin arginine targeting (tat) family # TIGRFAMs TIGR01410 tatB # eggNOG COG1826 LUCA # eggNOG ENOG4105X8U Bacteria BLAST swissprot:TATB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TATB_ECOLI BioCyc ECOL316407:JW5580-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5580-MONOMER BioCyc EcoCyc:G7808-MONOMER http://biocyc.org/getid?id=EcoCyc:G7808-MONOMER BioCyc MetaCyc:G7808-MONOMER http://biocyc.org/getid?id=MetaCyc:G7808-MONOMER COG COG1826 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1826 DIP DIP-58536N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-58536N DOI 10.1006/jmbi.2002.5431 http://dx.doi.org/10.1006/jmbi.2002.5431 DOI 10.1016/S0014-5793(01)02904-0 http://dx.doi.org/10.1016/S0014-5793(01)02904-0 DOI 10.1016/S0092-8674(00)81149-6 http://dx.doi.org/10.1016/S0092-8674(00)81149-6 DOI 10.1016/S1097-2765(03)00398-8 http://dx.doi.org/10.1016/S1097-2765(03)00398-8 DOI 10.1016/j.febslet.2004.05.054 http://dx.doi.org/10.1016/j.febslet.2004.05.054 DOI 10.1016/j.febslet.2007.07.044 http://dx.doi.org/10.1016/j.febslet.2007.07.044 DOI 10.1016/j.febslet.2011.01.016 http://dx.doi.org/10.1016/j.febslet.2011.01.016 DOI 10.1016/j.jmb.2004.10.043 http://dx.doi.org/10.1016/j.jmb.2004.10.043 DOI 10.1016/j.jmb.2004.11.047 http://dx.doi.org/10.1016/j.jmb.2004.11.047 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2000.01719.x http://dx.doi.org/10.1046/j.1365-2958.2000.01719.x DOI 10.1046/j.1432-1327.2001.02263.x http://dx.doi.org/10.1046/j.1432-1327.2001.02263.x DOI 10.1073/pnas.0901566106 http://dx.doi.org/10.1073/pnas.0901566106 DOI 10.1074/jbc.274.51.36073 http://dx.doi.org/10.1074/jbc.274.51.36073 DOI 10.1074/jbc.M100682200 http://dx.doi.org/10.1074/jbc.M100682200 DOI 10.1091/mbc.E10-07-0585 http://dx.doi.org/10.1091/mbc.E10-07-0585 DOI 10.1093/emboj/17.13.3640 http://dx.doi.org/10.1093/emboj/17.13.3640 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.183.5.1801-1804.2001 http://dx.doi.org/10.1128/JB.183.5.1801-1804.2001 DOI 10.1371/journal.pone.0009225 http://dx.doi.org/10.1371/journal.pone.0009225 EMBL AF067848 http://www.ebi.ac.uk/ena/data/view/AF067848 EMBL AJ005830 http://www.ebi.ac.uk/ena/data/view/AJ005830 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4068 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4068 EcoGene EG14322 http://www.ecogene.org/geneInfo.php?eg_id=EG14322 EnsemblBacteria AAT48228 http://www.ensemblgenomes.org/id/AAT48228 EnsemblBacteria AAT48228 http://www.ensemblgenomes.org/id/AAT48228 EnsemblBacteria BAE77464 http://www.ensemblgenomes.org/id/BAE77464 EnsemblBacteria BAE77464 http://www.ensemblgenomes.org/id/BAE77464 EnsemblBacteria BAE77464 http://www.ensemblgenomes.org/id/BAE77464 EnsemblBacteria b3838 http://www.ensemblgenomes.org/id/b3838 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0033281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033281 GO_function GO:0009977 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009977 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0009306 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009306 GO_process GO:0043953 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043953 GO_process GO:0065002 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0065002 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 948319 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948319 HAMAP MF_00237 http://hamap.expasy.org/unirule/MF_00237 HOGENOM HOG000245368 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000245368&db=HOGENOM6 InParanoid P69425 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P69425 IntAct P69425 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69425* InterPro IPR003998 http://www.ebi.ac.uk/interpro/entry/IPR003998 InterPro IPR018448 http://www.ebi.ac.uk/interpro/entry/IPR018448 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW5580 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5580 KEGG_Gene eco:b3838 http://www.genome.jp/dbget-bin/www_bget?eco:b3838 KEGG_Orthology KO:K03117 http://www.genome.jp/dbget-bin/www_bget?KO:K03117 KEGG_Pathway ko03060 http://www.genome.jp/kegg-bin/show_pathway?ko03060 KEGG_Pathway ko03070 http://www.genome.jp/kegg-bin/show_pathway?ko03070 MINT MINT-8082940 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8082940 OMA NEAQHEG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NEAQHEG PRINTS PR01506 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01506 PSORT swissprot:TATB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TATB_ECOLI PSORT-B swissprot:TATB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TATB_ECOLI PSORT2 swissprot:TATB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TATB_ECOLI Phobius swissprot:TATB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TATB_ECOLI ProteinModelPortal P69425 http://www.proteinmodelportal.org/query/uniprot/P69425 PubMed 10593889 http://www.ncbi.nlm.nih.gov/pubmed/10593889 PubMed 10652088 http://www.ncbi.nlm.nih.gov/pubmed/10652088 PubMed 11160116 http://www.ncbi.nlm.nih.gov/pubmed/11160116 PubMed 11279240 http://www.ncbi.nlm.nih.gov/pubmed/11279240 PubMed 11422364 http://www.ncbi.nlm.nih.gov/pubmed/11422364 PubMed 11591389 http://www.ncbi.nlm.nih.gov/pubmed/11591389 PubMed 11922668 http://www.ncbi.nlm.nih.gov/pubmed/11922668 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 14580344 http://www.ncbi.nlm.nih.gov/pubmed/14580344 PubMed 15225613 http://www.ncbi.nlm.nih.gov/pubmed/15225613 PubMed 15571732 http://www.ncbi.nlm.nih.gov/pubmed/15571732 PubMed 15663945 http://www.ncbi.nlm.nih.gov/pubmed/15663945 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17686475 http://www.ncbi.nlm.nih.gov/pubmed/17686475 PubMed 19666509 http://www.ncbi.nlm.nih.gov/pubmed/19666509 PubMed 20169075 http://www.ncbi.nlm.nih.gov/pubmed/20169075 PubMed 20926683 http://www.ncbi.nlm.nih.gov/pubmed/20926683 PubMed 21237157 http://www.ncbi.nlm.nih.gov/pubmed/21237157 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9546395 http://www.ncbi.nlm.nih.gov/pubmed/9546395 PubMed 9649434 http://www.ncbi.nlm.nih.gov/pubmed/9649434 RefSeq WP_000459594 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000459594 RefSeq YP_026270 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026270 SMR P69425 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69425 STRING 511145.b3838 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3838&targetmode=cogs STRING COG1826 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1826&targetmode=cogs TCDB 2.A.64.1 http://www.tcdb.org/search/result.php?tc=2.A.64.1 TIGRFAMs TIGR01410 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01410 UniProtKB TATB_ECOLI http://www.uniprot.org/uniprot/TATB_ECOLI UniProtKB-AC P69425 http://www.uniprot.org/uniprot/P69425 charge swissprot:TATB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TATB_ECOLI eggNOG COG1826 http://eggnogapi.embl.de/nog_data/html/tree/COG1826 eggNOG ENOG4105X8U http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105X8U epestfind swissprot:TATB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TATB_ECOLI garnier swissprot:TATB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TATB_ECOLI helixturnhelix swissprot:TATB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TATB_ECOLI hmoment swissprot:TATB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TATB_ECOLI iep swissprot:TATB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TATB_ECOLI inforesidue swissprot:TATB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TATB_ECOLI octanol swissprot:TATB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TATB_ECOLI pepcoil swissprot:TATB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TATB_ECOLI pepdigest swissprot:TATB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TATB_ECOLI pepinfo swissprot:TATB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TATB_ECOLI pepnet swissprot:TATB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TATB_ECOLI pepstats swissprot:TATB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TATB_ECOLI pepwheel swissprot:TATB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TATB_ECOLI pepwindow swissprot:TATB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TATB_ECOLI sigcleave swissprot:TATB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TATB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260391 6 # DOMAIN FLIK_ECOLI Two-domain protein with the central portion of the sequence acting as a hinge or connector between the two. # EcoGene EG20268 fliK # FUNCTION FLIK_ECOLI Controls the length of the flagellar hook. # GO_component GO:0009424 bacterial-type flagellum hook; IMP:EcoliWiki. # GO_process GO:0044780 bacterial-type flagellum assembly; IEA:InterPro. # GO_process GO:0071973 bacterial-type flagellum-dependent cell motility; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0048870 cell motility # IntAct P52614 15 # InterPro IPR001635 Flag_hook_Flik # InterPro IPR021136 Flagellar_hook_control-like_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Pathway ko02040 Flagellar assembly # Organism FLIK_ECOLI Escherichia coli (strain K12) # PATRIC 32119215 VBIEscCol129921_2022 # PIR D64958 D64958 # PRINTS PR01007 FLGHOOKFLIK # Pfam PF02120 Flg_hook # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FLIK_ECOLI Flagellar hook-length control protein # RefSeq NP_416453 NC_000913.3 # RefSeq WP_000620071 NZ_LN832404.1 # SIMILARITY Belongs to the FliK family. {ECO 0000305}. # eggNOG COG3144 LUCA # eggNOG ENOG4105WF4 Bacteria BLAST swissprot:FLIK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLIK_ECOLI BioCyc ECOL316407:JW1927-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1927-MONOMER BioCyc EcoCyc:G379-MONOMER http://biocyc.org/getid?id=EcoCyc:G379-MONOMER COG COG3144 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3144 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L43491 http://www.ebi.ac.uk/ena/data/view/L43491 EMBL L49147 http://www.ebi.ac.uk/ena/data/view/L49147 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4165 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4165 EcoGene EG20268 http://www.ecogene.org/geneInfo.php?eg_id=EG20268 EnsemblBacteria AAC75010 http://www.ensemblgenomes.org/id/AAC75010 EnsemblBacteria AAC75010 http://www.ensemblgenomes.org/id/AAC75010 EnsemblBacteria BAA15768 http://www.ensemblgenomes.org/id/BAA15768 EnsemblBacteria BAA15768 http://www.ensemblgenomes.org/id/BAA15768 EnsemblBacteria BAA15768 http://www.ensemblgenomes.org/id/BAA15768 EnsemblBacteria b1943 http://www.ensemblgenomes.org/id/b1943 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009424 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009424 GO_process GO:0044780 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044780 GO_process GO:0071973 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071973 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 GeneID 946449 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946449 HOGENOM HOG000121331 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000121331&db=HOGENOM6 InParanoid P52614 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P52614 IntAct P52614 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P52614* InterPro IPR001635 http://www.ebi.ac.uk/interpro/entry/IPR001635 InterPro IPR021136 http://www.ebi.ac.uk/interpro/entry/IPR021136 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW1927 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1927 KEGG_Gene eco:b1943 http://www.genome.jp/dbget-bin/www_bget?eco:b1943 KEGG_Orthology KO:K02414 http://www.genome.jp/dbget-bin/www_bget?KO:K02414 KEGG_Pathway ko02040 http://www.genome.jp/kegg-bin/show_pathway?ko02040 OMA SHEWQQA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SHEWQQA PRINTS PR01007 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01007 PSORT swissprot:FLIK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLIK_ECOLI PSORT-B swissprot:FLIK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLIK_ECOLI PSORT2 swissprot:FLIK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLIK_ECOLI Pfam PF02120 http://pfam.xfam.org/family/PF02120 Phobius swissprot:FLIK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLIK_ECOLI ProteinModelPortal P52614 http://www.proteinmodelportal.org/query/uniprot/P52614 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8631687 http://www.ncbi.nlm.nih.gov/pubmed/8631687 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416453 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416453 RefSeq WP_000620071 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000620071 SMR P52614 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P52614 STRING 511145.b1943 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1943&targetmode=cogs STRING COG3144 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3144&targetmode=cogs UniProtKB FLIK_ECOLI http://www.uniprot.org/uniprot/FLIK_ECOLI UniProtKB-AC P52614 http://www.uniprot.org/uniprot/P52614 charge swissprot:FLIK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLIK_ECOLI eggNOG COG3144 http://eggnogapi.embl.de/nog_data/html/tree/COG3144 eggNOG ENOG4105WF4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105WF4 epestfind swissprot:FLIK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLIK_ECOLI garnier swissprot:FLIK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLIK_ECOLI helixturnhelix swissprot:FLIK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLIK_ECOLI hmoment swissprot:FLIK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLIK_ECOLI iep swissprot:FLIK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLIK_ECOLI inforesidue swissprot:FLIK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLIK_ECOLI octanol swissprot:FLIK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLIK_ECOLI pepcoil swissprot:FLIK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLIK_ECOLI pepdigest swissprot:FLIK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLIK_ECOLI pepinfo swissprot:FLIK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLIK_ECOLI pepnet swissprot:FLIK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLIK_ECOLI pepstats swissprot:FLIK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLIK_ECOLI pepwheel swissprot:FLIK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLIK_ECOLI pepwindow swissprot:FLIK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLIK_ECOLI sigcleave swissprot:FLIK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLIK_ECOLI ## Database ID URL or Descriptions # BRENDA 3.4.21.B30 2026 # BioGrid 4261817 117 # EcoGene EG11057 umuD # FUNCTION UMUD_ECOLI Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_function GO:0003887 DNA-directed DNA polymerase activity; IDA:EcoCyc. # GO_function GO:0008236 serine-type peptidase activity; IEA:UniProtKB-KW. # GO_process GO:0006281 DNA repair; IMP:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:InterPro. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0009432 SOS response; IMP:EcoCyc. # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # Gene3D 2.10.109.10 -; 1. # INDUCTION Induced 1.5-fold by hydroxyurea. {ECO:0000269|PubMed 20005847}. # IntAct P0AG11 13 # InterPro IPR006197 Peptidase_S24_LexA # InterPro IPR015927 Peptidase_S24_S26A/B/C # InterPro IPR019759 Peptidase_S24_S26 # InterPro IPR028360 Peptidase_S24/S26_b-rbn # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # KEGG_Brite ko03400 DNA repair and recombination proteins # Organism UMUD_ECOLI Escherichia coli (strain K12) # PATRIC 32117612 VBIEscCol129921_1228 # PDB 1AY9 X-ray; 3.00 A; A/B=32-139 # PDB 1I4V NMR; -; A/B=26-139 # PDB 1UMU X-ray; 2.50 A; A/B=25-137 # PIR A03551 ZWECD # PRINTS PR00726 LEXASERPTASE # Pfam PF00717 Peptidase_S24 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UMUD_ECOLI Protein UmuD # RecName UMUD_ECOLI Protein UmuD' # RefSeq NP_415701 NC_000913.3 # RefSeq WP_000897378 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase S24 family. {ECO 0000305}. # SUPFAM SSF51306 SSF51306 # eggNOG COG1974 LUCA # eggNOG ENOG4105KT5 Bacteria BLAST swissprot:UMUD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UMUD_ECOLI BioCyc ECOL316407:JW1172-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1172-MONOMER BioCyc EcoCyc:EG11057-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11057-MONOMER BioCyc MetaCyc:EG11057-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11057-MONOMER COG COG1974 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1974 DIP DIP-29679N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-29679N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1007/BF00265442 http://dx.doi.org/10.1007/BF00265442 DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/380727a0 http://dx.doi.org/10.1038/380727a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.82.13.4331 http://dx.doi.org/10.1073/pnas.82.13.4331 DOI 10.1073/pnas.82.13.4336 http://dx.doi.org/10.1073/pnas.82.13.4336 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DisProt DP00626 http://www.disprot.org/protein.php?id=DP00626 EC_number EC:3.4.21.- http://www.genome.jp/dbget-bin/www_bget?EC:3.4.21.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M10107 http://www.ebi.ac.uk/ena/data/view/M10107 EMBL M13387 http://www.ebi.ac.uk/ena/data/view/M13387 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.4.21.- http://enzyme.expasy.org/EC/3.4.21.- EchoBASE EB1050 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1050 EcoGene EG11057 http://www.ecogene.org/geneInfo.php?eg_id=EG11057 EnsemblBacteria AAC74267 http://www.ensemblgenomes.org/id/AAC74267 EnsemblBacteria AAC74267 http://www.ensemblgenomes.org/id/AAC74267 EnsemblBacteria BAA36030 http://www.ensemblgenomes.org/id/BAA36030 EnsemblBacteria BAA36030 http://www.ensemblgenomes.org/id/BAA36030 EnsemblBacteria BAA36030 http://www.ensemblgenomes.org/id/BAA36030 EnsemblBacteria b1183 http://www.ensemblgenomes.org/id/b1183 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003887 GO_function GO:0008236 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008236 GO_process GO:0006281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006281 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0009432 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009432 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 2.10.109.10 http://www.cathdb.info/version/latest/superfamily/2.10.109.10 GeneID 945746 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945746 HOGENOM HOG000232166 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000232166&db=HOGENOM6 InParanoid P0AG11 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AG11 IntAct P0AG11 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AG11* IntEnz 3.4.21 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.21 InterPro IPR006197 http://www.ebi.ac.uk/interpro/entry/IPR006197 InterPro IPR015927 http://www.ebi.ac.uk/interpro/entry/IPR015927 InterPro IPR019759 http://www.ebi.ac.uk/interpro/entry/IPR019759 InterPro IPR028360 http://www.ebi.ac.uk/interpro/entry/IPR028360 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW1172 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1172 KEGG_Gene eco:b1183 http://www.genome.jp/dbget-bin/www_bget?eco:b1183 KEGG_Orthology KO:K03503 http://www.genome.jp/dbget-bin/www_bget?KO:K03503 OMA FMERVSA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FMERVSA PDB 1AY9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1AY9 PDB 1I4V http://www.ebi.ac.uk/pdbe-srv/view/entry/1I4V PDB 1UMU http://www.ebi.ac.uk/pdbe-srv/view/entry/1UMU PDBsum 1AY9 http://www.ebi.ac.uk/pdbsum/1AY9 PDBsum 1I4V http://www.ebi.ac.uk/pdbsum/1I4V PDBsum 1UMU http://www.ebi.ac.uk/pdbsum/1UMU PRINTS PR00726 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00726 PSORT swissprot:UMUD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UMUD_ECOLI PSORT-B swissprot:UMUD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UMUD_ECOLI PSORT2 swissprot:UMUD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UMUD_ECOLI Pfam PF00717 http://pfam.xfam.org/family/PF00717 Phobius swissprot:UMUD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UMUD_ECOLI PhylomeDB P0AG11 http://phylomedb.org/?seqid=P0AG11 ProteinModelPortal P0AG11 http://www.proteinmodelportal.org/query/uniprot/P0AG11 PubMed 1320188 http://www.ncbi.nlm.nih.gov/pubmed/1320188 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 2989816 http://www.ncbi.nlm.nih.gov/pubmed/2989816 PubMed 2989817 http://www.ncbi.nlm.nih.gov/pubmed/2989817 PubMed 8614470 http://www.ncbi.nlm.nih.gov/pubmed/8614470 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_415701 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415701 RefSeq WP_000897378 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000897378 SMR P0AG11 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AG11 STRING 511145.b1183 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1183&targetmode=cogs STRING COG1974 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1974&targetmode=cogs SUPFAM SSF51306 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51306 UniProtKB UMUD_ECOLI http://www.uniprot.org/uniprot/UMUD_ECOLI UniProtKB-AC P0AG11 http://www.uniprot.org/uniprot/P0AG11 charge swissprot:UMUD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UMUD_ECOLI eggNOG COG1974 http://eggnogapi.embl.de/nog_data/html/tree/COG1974 eggNOG ENOG4105KT5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KT5 epestfind swissprot:UMUD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UMUD_ECOLI garnier swissprot:UMUD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UMUD_ECOLI helixturnhelix swissprot:UMUD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UMUD_ECOLI hmoment swissprot:UMUD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UMUD_ECOLI iep swissprot:UMUD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UMUD_ECOLI inforesidue swissprot:UMUD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UMUD_ECOLI octanol swissprot:UMUD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UMUD_ECOLI pepcoil swissprot:UMUD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UMUD_ECOLI pepdigest swissprot:UMUD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UMUD_ECOLI pepinfo swissprot:UMUD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UMUD_ECOLI pepnet swissprot:UMUD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UMUD_ECOLI pepstats swissprot:UMUD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UMUD_ECOLI pepwheel swissprot:UMUD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UMUD_ECOLI pepwindow swissprot:UMUD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UMUD_ECOLI sigcleave swissprot:UMUD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UMUD_ECOLI ## Database ID URL or Descriptions # BioGrid 4260797 9 # EcoGene EG12826 tldD # FUNCTION TLDD_ECOLI Metalloprotease involved in CcdA degradation. Suppresses the inhibitory activity of the carbon storage regulator (CsrA). {ECO 0000269|PubMed 12029038}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008237 metallopeptidase activity; IBA:GO_Central. # GO_function GO:0008270 zinc ion binding; IBA:GO_Central. # GO_process GO:0006508 proteolysis; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # IntAct P0AGG8 4 # InterPro IPR002510 TldD/PmbA # InterPro IPR025502 TldD # KEGG_Brite ko01002 Peptidases # MISCELLANEOUS In strains containing the pMccB17 plasmid, required for the maturation and secretion of the antibiotic bacteriocin microcin B17 (MccB17). {ECO:0000305|PubMed 12029038}. # Organism TLDD_ECOLI Escherichia coli (strain K12) # PATRIC 32121914 VBIEscCol129921_3341 # PIR F65116 F65116 # PIRSF PIRSF004919 TldD # Pfam PF01523 PmbA_TldD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TLDD_ECOLI Metalloprotease TldD # RefSeq NP_417711 NC_000913.3 # RefSeq WP_000055909 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase U62 family. {ECO 0000305}. # eggNOG COG0312 LUCA # eggNOG ENOG4105D1U Bacteria BLAST swissprot:TLDD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TLDD_ECOLI BioCyc ECOL316407:JW3213-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3213-MONOMER BioCyc EcoCyc:G7689-MONOMER http://biocyc.org/getid?id=EcoCyc:G7689-MONOMER COG COG0312 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0312 DIP DIP-47845N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47845N DOI 10.1006/jmbi.1996.0103 http://dx.doi.org/10.1006/jmbi.1996.0103 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.12.3224-3231.2002 http://dx.doi.org/10.1128/JB.184.12.3224-3231.2002 EC_number EC:3.4.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.4.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D44451 http://www.ebi.ac.uk/ena/data/view/D44451 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 3.4.-.- http://enzyme.expasy.org/EC/3.4.-.- EchoBASE EB2677 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2677 EcoGene EG12826 http://www.ecogene.org/geneInfo.php?eg_id=EG12826 EnsemblBacteria AAC76276 http://www.ensemblgenomes.org/id/AAC76276 EnsemblBacteria AAC76276 http://www.ensemblgenomes.org/id/AAC76276 EnsemblBacteria BAE77287 http://www.ensemblgenomes.org/id/BAE77287 EnsemblBacteria BAE77287 http://www.ensemblgenomes.org/id/BAE77287 EnsemblBacteria BAE77287 http://www.ensemblgenomes.org/id/BAE77287 EnsemblBacteria b3244 http://www.ensemblgenomes.org/id/b3244 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008237 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008237 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_process GO:0006508 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006508 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 947749 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947749 HOGENOM HOG000224929 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000224929&db=HOGENOM6 InParanoid P0AGG8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGG8 IntAct P0AGG8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AGG8* IntEnz 3.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4 InterPro IPR002510 http://www.ebi.ac.uk/interpro/entry/IPR002510 InterPro IPR025502 http://www.ebi.ac.uk/interpro/entry/IPR025502 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW3213 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3213 KEGG_Gene eco:b3244 http://www.genome.jp/dbget-bin/www_bget?eco:b3244 KEGG_Orthology KO:K03568 http://www.genome.jp/dbget-bin/www_bget?KO:K03568 OMA PGVGTCG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PGVGTCG PSORT swissprot:TLDD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TLDD_ECOLI PSORT-B swissprot:TLDD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TLDD_ECOLI PSORT2 swissprot:TLDD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TLDD_ECOLI Pfam PF01523 http://pfam.xfam.org/family/PF01523 Phobius swissprot:TLDD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TLDD_ECOLI PhylomeDB P0AGG8 http://phylomedb.org/?seqid=P0AGG8 ProteinModelPortal P0AGG8 http://www.proteinmodelportal.org/query/uniprot/P0AGG8 PubMed 12029038 http://www.ncbi.nlm.nih.gov/pubmed/12029038 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8604133 http://www.ncbi.nlm.nih.gov/pubmed/8604133 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417711 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417711 RefSeq WP_000055909 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000055909 STRING 511145.b3244 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3244&targetmode=cogs STRING COG0312 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0312&targetmode=cogs UniProtKB TLDD_ECOLI http://www.uniprot.org/uniprot/TLDD_ECOLI UniProtKB-AC P0AGG8 http://www.uniprot.org/uniprot/P0AGG8 charge swissprot:TLDD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TLDD_ECOLI eggNOG COG0312 http://eggnogapi.embl.de/nog_data/html/tree/COG0312 eggNOG ENOG4105D1U http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D1U epestfind swissprot:TLDD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TLDD_ECOLI garnier swissprot:TLDD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TLDD_ECOLI helixturnhelix swissprot:TLDD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TLDD_ECOLI hmoment swissprot:TLDD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TLDD_ECOLI iep swissprot:TLDD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TLDD_ECOLI inforesidue swissprot:TLDD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TLDD_ECOLI octanol swissprot:TLDD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TLDD_ECOLI pepcoil swissprot:TLDD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TLDD_ECOLI pepdigest swissprot:TLDD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TLDD_ECOLI pepinfo swissprot:TLDD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TLDD_ECOLI pepnet swissprot:TLDD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TLDD_ECOLI pepstats swissprot:TLDD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TLDD_ECOLI pepwheel swissprot:TLDD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TLDD_ECOLI pepwindow swissprot:TLDD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TLDD_ECOLI sigcleave swissprot:TLDD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TLDD_ECOLI ## Database ID URL or Descriptions # BioGrid 4263207 13 # EcoGene EG12444 ycfJ # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_component GO:0019867 outer membrane; IEA:InterPro. # GO_process GO:1900190 regulation of single-species biofilm formation; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0008150 biological_process # InterPro IPR008816 Gly_zipper_2TM_dom # Organism YCFJ_ECOLI Escherichia coli (strain K12) # PATRIC 32117463 VBIEscCol129921_1154 # PIR C64855 C64855 # Pfam PF05433 Rick_17kDa_Anti # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCFJ_ECOLI Uncharacterized protein YcfJ # RefSeq NP_415628 NC_000913.3 # RefSeq WP_001043459 NZ_LN832404.1 # SIMILARITY To Rickettsia 17 kDa surface antigen. {ECO 0000305}. # SUBCELLULAR LOCATION YCFJ_ECOLI Membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. # eggNOG COG3134 LUCA # eggNOG ENOG4107MBR Bacteria BLAST swissprot:YCFJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCFJ_ECOLI BioCyc ECOL316407:JW1096-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1096-MONOMER BioCyc EcoCyc:EG12444-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12444-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1111/j.1432-1033.1981.tb05314.x http://dx.doi.org/10.1111/j.1432-1033.1981.tb05314.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00306 http://www.ebi.ac.uk/ena/data/view/V00306 EchoBASE EB2338 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2338 EcoGene EG12444 http://www.ecogene.org/geneInfo.php?eg_id=EG12444 EnsemblBacteria AAC74194 http://www.ensemblgenomes.org/id/AAC74194 EnsemblBacteria AAC74194 http://www.ensemblgenomes.org/id/AAC74194 EnsemblBacteria BAA35925 http://www.ensemblgenomes.org/id/BAA35925 EnsemblBacteria BAA35925 http://www.ensemblgenomes.org/id/BAA35925 EnsemblBacteria BAA35925 http://www.ensemblgenomes.org/id/BAA35925 EnsemblBacteria b1110 http://www.ensemblgenomes.org/id/b1110 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0019867 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019867 GO_process GO:1900190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1900190 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 945977 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945977 HOGENOM HOG000220582 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220582&db=HOGENOM6 InParanoid P0AB35 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AB35 IntAct P0AB35 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AB35* InterPro IPR008816 http://www.ebi.ac.uk/interpro/entry/IPR008816 KEGG_Gene ecj:JW1096 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1096 KEGG_Gene eco:b1110 http://www.genome.jp/dbget-bin/www_bget?eco:b1110 OMA PREVCKD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PREVCKD PSORT swissprot:YCFJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCFJ_ECOLI PSORT-B swissprot:YCFJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCFJ_ECOLI PSORT2 swissprot:YCFJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCFJ_ECOLI Pfam PF05433 http://pfam.xfam.org/family/PF05433 Phobius swissprot:YCFJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCFJ_ECOLI ProteinModelPortal P0AB35 http://www.proteinmodelportal.org/query/uniprot/P0AB35 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6265208 http://www.ncbi.nlm.nih.gov/pubmed/6265208 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415628 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415628 RefSeq WP_001043459 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001043459 STRING 511145.b1110 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1110&targetmode=cogs UniProtKB YCFJ_ECOLI http://www.uniprot.org/uniprot/YCFJ_ECOLI UniProtKB-AC P0AB35 http://www.uniprot.org/uniprot/P0AB35 charge swissprot:YCFJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCFJ_ECOLI eggNOG COG3134 http://eggnogapi.embl.de/nog_data/html/tree/COG3134 eggNOG ENOG4107MBR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107MBR epestfind swissprot:YCFJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCFJ_ECOLI garnier swissprot:YCFJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCFJ_ECOLI helixturnhelix swissprot:YCFJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCFJ_ECOLI hmoment swissprot:YCFJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCFJ_ECOLI iep swissprot:YCFJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCFJ_ECOLI inforesidue swissprot:YCFJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCFJ_ECOLI octanol swissprot:YCFJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCFJ_ECOLI pepcoil swissprot:YCFJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCFJ_ECOLI pepdigest swissprot:YCFJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCFJ_ECOLI pepinfo swissprot:YCFJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCFJ_ECOLI pepnet swissprot:YCFJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCFJ_ECOLI pepstats swissprot:YCFJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCFJ_ECOLI pepwheel swissprot:YCFJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCFJ_ECOLI pepwindow swissprot:YCFJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCFJ_ECOLI sigcleave swissprot:YCFJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCFJ_ECOLI ## Database ID URL or Descriptions # BRENDA 3.1.1 2026 # BioGrid 4261742 10 # ESTHER ecoli-yafa Duf_1100 # EcoGene EG11091 frsA # FUNCTION FRSA_ECOLI Displays esterase activity toward pNP-butyrate. {ECO 0000269|PubMed 15808744}. # GO_function GO:0016787 hydrolase activity; IDA:EcoCyc. # GO_function GO:0052689 carboxylic ester hydrolase activity; IEA:UniProtKB-KW. # GO_process GO:0043470 regulation of carbohydrate catabolic process; IMP:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.1820 -; 2. # HAMAP MF_01063 UPF0255 # IntAct P04335 6 # InterPro IPR010520 UPF0255 # InterPro IPR029058 AB_hydrolase # KEGG_Brite ko01000 Enzymes # Organism FRSA_ECOLI Escherichia coli (strain K12) # PATRIC 32115593 VBIEscCol129921_0241 # PIR H64748 QQEC49 # Pfam PF06500 DUF1100 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FRSA_ECOLI Esterase FrsA # RefSeq NP_414774 NC_000913.3 # RefSeq WP_000189532 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0255 family. {ECO 0000305}. # SUPFAM SSF53474 SSF53474 # eggNOG COG1073 LUCA # eggNOG ENOG4105V1F Bacteria BLAST swissprot:FRSA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FRSA_ECOLI BioCyc ECOL316407:JW0229-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0229-MONOMER BioCyc EcoCyc:EG11091-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11091-MONOMER COG COG1073 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1073 DIP DIP-11208N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11208N DOI 10.1016/0378-1119(84)90052-0 http://dx.doi.org/10.1016/0378-1119(84)90052-0 DOI 10.1016/j.fmrre.2004.12.006 http://dx.doi.org/10.1016/j.fmrre.2004.12.006 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M13422 http://www.ebi.ac.uk/ena/data/view/M13422 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 ENZYME 3.1.-.- http://enzyme.expasy.org/EC/3.1.-.- EchoBASE EB1083 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1083 EcoGene EG11091 http://www.ecogene.org/geneInfo.php?eg_id=EG11091 EnsemblBacteria AAC73343 http://www.ensemblgenomes.org/id/AAC73343 EnsemblBacteria AAC73343 http://www.ensemblgenomes.org/id/AAC73343 EnsemblBacteria BAA77908 http://www.ensemblgenomes.org/id/BAA77908 EnsemblBacteria BAA77908 http://www.ensemblgenomes.org/id/BAA77908 EnsemblBacteria BAA77908 http://www.ensemblgenomes.org/id/BAA77908 EnsemblBacteria b0239 http://www.ensemblgenomes.org/id/b0239 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016787 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016787 GO_function GO:0052689 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052689 GO_process GO:0043470 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043470 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.1820 http://www.cathdb.info/version/latest/superfamily/3.40.50.1820 GeneID 946039 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946039 HAMAP MF_01063 http://hamap.expasy.org/unirule/MF_01063 HOGENOM HOG000282295 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000282295&db=HOGENOM6 InParanoid P04335 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P04335 IntAct P04335 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P04335* IntEnz 3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1 InterPro IPR010520 http://www.ebi.ac.uk/interpro/entry/IPR010520 InterPro IPR029058 http://www.ebi.ac.uk/interpro/entry/IPR029058 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0229 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0229 KEGG_Gene eco:b0239 http://www.genome.jp/dbget-bin/www_bget?eco:b0239 KEGG_Orthology KO:K11750 http://www.genome.jp/dbget-bin/www_bget?KO:K11750 OMA IPWIDHT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IPWIDHT PSORT swissprot:FRSA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FRSA_ECOLI PSORT-B swissprot:FRSA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FRSA_ECOLI PSORT2 swissprot:FRSA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FRSA_ECOLI Pfam PF06500 http://pfam.xfam.org/family/PF06500 Phobius swissprot:FRSA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FRSA_ECOLI ProteinModelPortal P04335 http://www.proteinmodelportal.org/query/uniprot/P04335 PubMed 15808744 http://www.ncbi.nlm.nih.gov/pubmed/15808744 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6397401 http://www.ncbi.nlm.nih.gov/pubmed/6397401 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414774 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414774 RefSeq WP_000189532 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000189532 SMR P04335 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P04335 STRING 511145.b0239 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0239&targetmode=cogs STRING COG1073 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1073&targetmode=cogs SUPFAM SSF53474 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53474 UniProtKB FRSA_ECOLI http://www.uniprot.org/uniprot/FRSA_ECOLI UniProtKB-AC P04335 http://www.uniprot.org/uniprot/P04335 charge swissprot:FRSA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FRSA_ECOLI eggNOG COG1073 http://eggnogapi.embl.de/nog_data/html/tree/COG1073 eggNOG ENOG4105V1F http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105V1F epestfind swissprot:FRSA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FRSA_ECOLI garnier swissprot:FRSA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FRSA_ECOLI helixturnhelix swissprot:FRSA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FRSA_ECOLI hmoment swissprot:FRSA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FRSA_ECOLI iep swissprot:FRSA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FRSA_ECOLI inforesidue swissprot:FRSA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FRSA_ECOLI octanol swissprot:FRSA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FRSA_ECOLI pepcoil swissprot:FRSA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FRSA_ECOLI pepdigest swissprot:FRSA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FRSA_ECOLI pepinfo swissprot:FRSA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FRSA_ECOLI pepnet swissprot:FRSA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FRSA_ECOLI pepstats swissprot:FRSA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FRSA_ECOLI pepwheel swissprot:FRSA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FRSA_ECOLI pepwindow swissprot:FRSA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FRSA_ECOLI sigcleave swissprot:FRSA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FRSA_ECOLI ## Database ID URL or Descriptions # AltName Cadaverine aminopropyltransferase {ECO:0000305|PubMed 4572733} # AltName SPEE_ECOLI Putrescine aminopropyltransferase {ECO 0000255|HAMAP-Rule MF_00198, ECO 0000305|PubMed 4572733} # AltName SPEE_ECOLI Spermidine synthase {ECO 0000255|HAMAP-Rule MF_00198, ECO 0000303|PubMed 4572733} # AltName Spermidine aminopropyltransferase {ECO:0000305|PubMed 4572733} # AltName Spermine synthase {ECO:0000303|PubMed 4572733} # AltName Thermospermine synthase {ECO:0000305|PubMed 4572733} # BIOPHYSICOCHEMICAL PROPERTIES SPEE_ECOLI Kinetic parameters KM=2.2 uM for S-adenosylmethionine {ECO 0000269|PubMed 4572733}; KM=12 uM for putrescine {ECO 0000269|PubMed 4572733}; KM=77.77 uM for putrescine (at pH 7.5 and 37 degrees Celsius) {ECO 0000269|PubMed 23001854}; KM=84.98 uM for S-adenosylmethionine (at pH 7.5 and 37 degrees Celsius) {ECO 0000269|PubMed 23001854}; Vmax=2 umol/min/mg enzyme {ECO 0000269|PubMed 4572733}; Vmax=0.560 umol/min/mg enzyme (at pH 7.5 and 37 degrees Celsius) {ECO 0000269|PubMed 23001854}; pH dependence Optimum pH is 7.5. {ECO 0000269|PubMed 23001854}; Temperature dependence Optimum temperature is 50 degrees Celsius. {ECO 0000269|PubMed 23001854}; # BRENDA 2.5.1.16 2026 # BioGrid 4262092 235 # CATALYTIC ACTIVITY S-adenosyl 3-(methylthio)propylamine + 1,5- diaminopentane = S-methyl-5'-thioadenosine + N-(3-aminopropyl)- 1,5-diaminopentane. {ECO:0000269|PubMed 4572733}. # CATALYTIC ACTIVITY S-adenosyl 3-(methylthio)propylamine + spermidine = S-methyl-5'-thioadenosine + spermine. {ECO:0000269|PubMed 4572733}. # CATALYTIC ACTIVITY S-adenosyl 3-(methylthio)propylamine + spermidine = S-methyl-5'-thioadenosine + thermospermine + H(+). {ECO:0000269|PubMed 4572733}. # CATALYTIC ACTIVITY SPEE_ECOLI S-adenosyl 3-(methylthio)propylamine + putrescine = 5'-S-methyl-5'-thioadenosine + spermidine. {ECO 0000255|HAMAP-Rule MF_00198, ECO 0000269|PubMed 23001854, ECO 0000269|PubMed 4572733}. # ENZYME REGULATION SPEE_ECOLI The activity is thought to be regulated mainly by the availability of decarboxylated S-adenosylmethionine. Inhibited by dicyclohexylamine, S-adenosyl-1,8-diamino-3- thiooctane (AdoDATO), sulfonium-deaminated analogs of S- adenosyl(5')-3-methylthiopropylamine, p-hydroxymercuribenzoate and N-ethylmaleimide. {ECO 0000269|PubMed 4572733, ECO 0000269|PubMed 6406265, ECO 0000269|PubMed 6508744, ECO 0000269|PubMed 6993485}. # EcoGene EG10963 speE # FUNCTION SPEE_ECOLI Involved in the biosynthesis of polyamines which play a significant role in the structural and functional organization in the chromoid of E.coli by compacting DNA and neutralizing negative charges. Catalyzes the irreversible transfer (ping-pong mechanism) of a propylamine group from the amino donor S- adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4- diaminobutane) to yield spermidine. Cadaverine (1,5- diaminopentane) and spermidine can also be used as the propylamine acceptor. {ECO 0000269|PubMed 23001854, ECO 0000269|PubMed 4572733}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0004766 spermidine synthase activity; IDA:EcoCyc. # GO_function GO:0010487 thermospermine synthase activity; IDA:UniProtKB. # GO_function GO:0016768 spermine synthase activity; IEA:UniProtKB-EC. # GO_function GO:0043918 cadaverine aminopropyltransferase activity; IDA:UniProtKB. # GO_process GO:0008295 spermidine biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.50.150 -; 1. # HAMAP MF_00198 Spermidine_synth # IntAct P09158 11 # InterPro IPR001045 Spermi_synthase # InterPro IPR029063 SAM-dependent_MTases # InterPro IPR030373 PABS_CS # InterPro IPR030374 PABS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00270 Cysteine and methionine metabolism # KEGG_Pathway ko00330 Arginine and proline metabolism # KEGG_Pathway ko00410 beta-Alanine metabolism # KEGG_Pathway ko00480 Glutathione metabolism # MASS SPECTROMETRY Mass=33823; Method=Electrospray; Range=1-288; Evidence={ECO:0000269|PubMed 23001854}; # Organism SPEE_ECOLI Escherichia coli (strain K12) # PATHWAY Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1. {ECO 0000255|HAMAP-Rule:MF_00198}. # PATRIC 32115343 VBIEscCol129921_0123 # PDB 3O4F X-ray; 2.90 A; A/B/C/D/E/F/G/H=1-288 # PIR A29778 SYECSD # PROSITE PS01330 PABS_1 # PROSITE PS51006 PABS_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SPEE_ECOLI Polyamine aminopropyltransferase {ECO 0000255|HAMAP-Rule MF_00198, ECO 0000303|PubMed 4572733} # RefSeq NP_414663 NC_000913.3 # RefSeq WP_000818411 NZ_LN832404.1 # SIMILARITY Belongs to the spermidine/spermine synthase family. {ECO:0000255|HAMAP-Rule MF_00198}. # SIMILARITY Contains 1 PABS (polyamine biosynthesis) domain. {ECO:0000255|HAMAP-Rule MF_00198}. # SUBCELLULAR LOCATION SPEE_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00198}. # SUBUNIT SPEE_ECOLI Homodimer. {ECO 0000269|PubMed 20051267, ECO 0000269|PubMed 4572733}. # SUPFAM SSF53335 SSF53335 # TIGRFAMs TIGR00417 speE # UniPathway UPA00248 UER00314 # eggNOG COG0421 LUCA # eggNOG ENOG4105CCX Bacteria BLAST swissprot:SPEE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SPEE_ECOLI BioCyc ECOL316407:JW0117-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0117-MONOMER BioCyc EcoCyc:SPERMIDINESYN-MONOMER http://biocyc.org/getid?id=EcoCyc:SPERMIDINESYN-MONOMER BioCyc MetaCyc:SPERMIDINESYN-MONOMER http://biocyc.org/getid?id=MetaCyc:SPERMIDINESYN-MONOMER COG COG0421 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0421 DOI 10.1007/s12033-012-9599-3 http://dx.doi.org/10.1007/s12033-012-9599-3 DOI 10.1016/0014-5793(82)80600-5 http://dx.doi.org/10.1016/0014-5793(82)80600-5 DOI 10.1016/j.jsb.2009.12.024 http://dx.doi.org/10.1016/j.jsb.2009.12.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2230823 http://dx.doi.org/10.1042/bj2230823 DOI 10.1073/pnas.83.16.6040 http://dx.doi.org/10.1073/pnas.83.16.6040 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.5.1.- {ECO:0000269|PubMed:4572733} http://www.genome.jp/dbget-bin/www_bget?EC:2.5.1.- {ECO:0000269|PubMed:4572733} EC_number EC:2.5.1.16 {ECO:0000255|HAMAP-Rule:MF_00198, ECO:0000269|PubMed:23001854, ECO:0000269|PubMed:4572733} http://www.genome.jp/dbget-bin/www_bget?EC:2.5.1.16 {ECO:0000255|HAMAP-Rule:MF_00198, ECO:0000269|PubMed:23001854, ECO:0000269|PubMed:4572733} EC_number EC:2.5.1.22 {ECO:0000269|PubMed:4572733} http://www.genome.jp/dbget-bin/www_bget?EC:2.5.1.22 {ECO:0000269|PubMed:4572733} EC_number EC:2.5.1.79 {ECO:0000269|PubMed:4572733} http://www.genome.jp/dbget-bin/www_bget?EC:2.5.1.79 {ECO:0000269|PubMed:4572733} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J02804 http://www.ebi.ac.uk/ena/data/view/J02804 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.5.1.- {ECO:0000269|PubMed:4572733} http://enzyme.expasy.org/EC/2.5.1.- {ECO:0000269|PubMed:4572733} ENZYME 2.5.1.16 {ECO:0000255|HAMAP-Rule:MF_00198, ECO:0000269|PubMed:23001854, ECO:0000269|PubMed:4572733} http://enzyme.expasy.org/EC/2.5.1.16 {ECO:0000255|HAMAP-Rule:MF_00198, ECO:0000269|PubMed:23001854, ECO:0000269|PubMed:4572733} ENZYME 2.5.1.22 {ECO:0000269|PubMed:4572733} http://enzyme.expasy.org/EC/2.5.1.22 {ECO:0000269|PubMed:4572733} ENZYME 2.5.1.79 {ECO:0000269|PubMed:4572733} http://enzyme.expasy.org/EC/2.5.1.79 {ECO:0000269|PubMed:4572733} EchoBASE EB0956 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0956 EcoGene EG10963 http://www.ecogene.org/geneInfo.php?eg_id=EG10963 EnsemblBacteria AAC73232 http://www.ensemblgenomes.org/id/AAC73232 EnsemblBacteria AAC73232 http://www.ensemblgenomes.org/id/AAC73232 EnsemblBacteria BAB96695 http://www.ensemblgenomes.org/id/BAB96695 EnsemblBacteria BAB96695 http://www.ensemblgenomes.org/id/BAB96695 EnsemblBacteria BAB96695 http://www.ensemblgenomes.org/id/BAB96695 EnsemblBacteria b0121 http://www.ensemblgenomes.org/id/b0121 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004766 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004766 GO_function GO:0010487 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010487 GO_function GO:0016768 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016768 GO_function GO:0043918 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043918 GO_process GO:0008295 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008295 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016765 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 GeneID 947726 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947726 HAMAP MF_00198 http://hamap.expasy.org/unirule/MF_00198 HOGENOM HOG000256146 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000256146&db=HOGENOM6 InParanoid P09158 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P09158 IntAct P09158 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P09158* IntEnz 2.5.1.- {ECO:0000269|PubMed:4572733} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.5.1.- {ECO:0000269|PubMed:4572733} IntEnz 2.5.1.16 {ECO:0000255|HAMAP-Rule:MF_00198, ECO:0000269|PubMed:23001854, ECO:0000269|PubMed:4572733} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.5.1.16 {ECO:0000255|HAMAP-Rule:MF_00198, ECO:0000269|PubMed:23001854, ECO:0000269|PubMed:4572733} IntEnz 2.5.1.22 {ECO:0000269|PubMed:4572733} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.5.1.22 {ECO:0000269|PubMed:4572733} IntEnz 2.5.1.79 {ECO:0000269|PubMed:4572733} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.5.1.79 {ECO:0000269|PubMed:4572733} InterPro IPR001045 http://www.ebi.ac.uk/interpro/entry/IPR001045 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 InterPro IPR030373 http://www.ebi.ac.uk/interpro/entry/IPR030373 InterPro IPR030374 http://www.ebi.ac.uk/interpro/entry/IPR030374 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0117 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0117 KEGG_Gene eco:b0121 http://www.genome.jp/dbget-bin/www_bget?eco:b0121 KEGG_Orthology KO:K00797 http://www.genome.jp/dbget-bin/www_bget?KO:K00797 KEGG_Pathway ko00270 http://www.genome.jp/kegg-bin/show_pathway?ko00270 KEGG_Pathway ko00330 http://www.genome.jp/kegg-bin/show_pathway?ko00330 KEGG_Pathway ko00410 http://www.genome.jp/kegg-bin/show_pathway?ko00410 KEGG_Pathway ko00480 http://www.genome.jp/kegg-bin/show_pathway?ko00480 KEGG_Reaction rn:R01920 http://www.genome.jp/dbget-bin/www_bget?rn:R01920 KEGG_Reaction rn:R02869 http://www.genome.jp/dbget-bin/www_bget?rn:R02869 KEGG_Reaction rn:R08359 http://www.genome.jp/dbget-bin/www_bget?rn:R08359 MINT MINT-1231846 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1231846 OMA SGLWSFT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SGLWSFT PDB 3O4F http://www.ebi.ac.uk/pdbe-srv/view/entry/3O4F PDBsum 3O4F http://www.ebi.ac.uk/pdbsum/3O4F PROSITE PS01330 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01330 PROSITE PS51006 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51006 PSORT swissprot:SPEE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SPEE_ECOLI PSORT-B swissprot:SPEE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SPEE_ECOLI PSORT2 swissprot:SPEE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SPEE_ECOLI Phobius swissprot:SPEE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SPEE_ECOLI PhylomeDB P09158 http://phylomedb.org/?seqid=P09158 ProteinModelPortal P09158 http://www.proteinmodelportal.org/query/uniprot/P09158 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20051267 http://www.ncbi.nlm.nih.gov/pubmed/20051267 PubMed 23001854 http://www.ncbi.nlm.nih.gov/pubmed/23001854 PubMed 2666401 http://www.ncbi.nlm.nih.gov/pubmed/2666401 PubMed 3316212 http://www.ncbi.nlm.nih.gov/pubmed/3316212 PubMed 3526348 http://www.ncbi.nlm.nih.gov/pubmed/3526348 PubMed 4572733 http://www.ncbi.nlm.nih.gov/pubmed/4572733 PubMed 6406265 http://www.ncbi.nlm.nih.gov/pubmed/6406265 PubMed 6508744 http://www.ncbi.nlm.nih.gov/pubmed/6508744 PubMed 6993485 http://www.ncbi.nlm.nih.gov/pubmed/6993485 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414663 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414663 RefSeq WP_000818411 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000818411 SMR P09158 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P09158 STRING 511145.b0121 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0121&targetmode=cogs STRING COG0421 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0421&targetmode=cogs SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 SWISS-2DPAGE P09158 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P09158 TIGRFAMs TIGR00417 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00417 UniProtKB SPEE_ECOLI http://www.uniprot.org/uniprot/SPEE_ECOLI UniProtKB-AC P09158 http://www.uniprot.org/uniprot/P09158 charge swissprot:SPEE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SPEE_ECOLI eggNOG COG0421 http://eggnogapi.embl.de/nog_data/html/tree/COG0421 eggNOG ENOG4105CCX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CCX epestfind swissprot:SPEE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SPEE_ECOLI garnier swissprot:SPEE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SPEE_ECOLI helixturnhelix swissprot:SPEE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SPEE_ECOLI hmoment swissprot:SPEE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SPEE_ECOLI iep swissprot:SPEE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SPEE_ECOLI inforesidue swissprot:SPEE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SPEE_ECOLI octanol swissprot:SPEE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SPEE_ECOLI pepcoil swissprot:SPEE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SPEE_ECOLI pepdigest swissprot:SPEE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SPEE_ECOLI pepinfo swissprot:SPEE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SPEE_ECOLI pepnet swissprot:SPEE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SPEE_ECOLI pepstats swissprot:SPEE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SPEE_ECOLI pepwheel swissprot:SPEE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SPEE_ECOLI pepwindow swissprot:SPEE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SPEE_ECOLI sigcleave swissprot:SPEE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SPEE_ECOLI ## Database ID URL or Descriptions # AltName 3MG1_ECOLI 3-methyladenine-DNA glycosylase I, constitutive # AltName 3MG1_ECOLI DNA-3-methyladenine glycosidase I # AltName 3MG1_ECOLI DNA-3-methyladenine glycosylase I # BRENDA 3.2.2.20 2026 # BioGrid 4261555 184 # CATALYTIC ACTIVITY Hydrolysis of alkylated DNA, releasing 3- methyladenine. {ECO:0000269|PubMed 3536912}. # ENZYME REGULATION Activity is controlled by product inhibition. {ECO:0000269|PubMed 3536912}. # EcoGene EG10986 tag # FUNCTION 3MG1_ECOLI Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine from the damaged DNA polymer formed by alkylation lesions. {ECO 0000269|PubMed 3536912}. # GO_function GO:0008725 DNA-3-methyladenine glycosylase activity; IEA:UniProtKB-EC. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006284 base-excision repair; IEA:InterPro. # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # Gene3D 1.10.340.30 -; 1. # IntAct P05100 5 # InterPro IPR004597 Tag # InterPro IPR005019 Adenine_glyco # InterPro IPR011257 DNA_glycosylase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko03410 Base excision repair # Organism 3MG1_ECOLI Escherichia coli (strain K12) # PATRIC 32122570 VBIEscCol129921_3662 # PDB 1LMZ NMR; -; A=1-187 # PDB 1NKU NMR; -; A=1-187 # PDB 1P7M NMR; -; A=1-187 # PIR A24604 DGECM1 # Pfam PF03352 Adenine_glyco # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 3MG1_ECOLI DNA-3-methyladenine glycosylase 1 # RefSeq NP_418005 NC_000913.3 # RefSeq WP_000438957 NZ_LN832404.1 # SUPFAM SSF48150 SSF48150 # TIGRFAMs TIGR00624 tag # eggNOG COG2818 LUCA # eggNOG ENOG4108R3E Bacteria BLAST swissprot:3MG1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:3MG1_ECOLI BioCyc ECOL316407:JW3518-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3518-MONOMER BioCyc EcoCyc:EG10986-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10986-MONOMER BioCyc MetaCyc:EG10986-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10986-MONOMER COG COG2818 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2818 DIP DIP-10950N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10950N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb829 http://dx.doi.org/10.1038/nsb829 DOI 10.1074/jbc.M300934200 http://dx.doi.org/10.1074/jbc.M300934200 DOI 10.1074/jbc.M307500200 http://dx.doi.org/10.1074/jbc.M307500200 DOI 10.1093/nar/14.9.3763 http://dx.doi.org/10.1093/nar/14.9.3763 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.2.2.20 {ECO:0000269|PubMed:3536912} http://www.genome.jp/dbget-bin/www_bget?EC:3.2.2.20 {ECO:0000269|PubMed:3536912} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J02606 http://www.ebi.ac.uk/ena/data/view/J02606 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X03845 http://www.ebi.ac.uk/ena/data/view/X03845 ENZYME 3.2.2.20 {ECO:0000269|PubMed:3536912} http://enzyme.expasy.org/EC/3.2.2.20 {ECO:0000269|PubMed:3536912} EchoBASE EB0979 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0979 EcoGene EG10986 http://www.ecogene.org/geneInfo.php?eg_id=EG10986 EnsemblBacteria AAC76573 http://www.ensemblgenomes.org/id/AAC76573 EnsemblBacteria AAC76573 http://www.ensemblgenomes.org/id/AAC76573 EnsemblBacteria BAE77746 http://www.ensemblgenomes.org/id/BAE77746 EnsemblBacteria BAE77746 http://www.ensemblgenomes.org/id/BAE77746 EnsemblBacteria BAE77746 http://www.ensemblgenomes.org/id/BAE77746 EnsemblBacteria b3549 http://www.ensemblgenomes.org/id/b3549 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008725 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008725 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006284 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006284 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 1.10.340.30 http://www.cathdb.info/version/latest/superfamily/1.10.340.30 GeneID 947137 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947137 HOGENOM HOG000220753 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220753&db=HOGENOM6 InParanoid P05100 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P05100 IntAct P05100 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P05100* IntEnz 3.2.2.20 {ECO:0000269|PubMed:3536912} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.2.2.20 {ECO:0000269|PubMed:3536912} InterPro IPR004597 http://www.ebi.ac.uk/interpro/entry/IPR004597 InterPro IPR005019 http://www.ebi.ac.uk/interpro/entry/IPR005019 InterPro IPR011257 http://www.ebi.ac.uk/interpro/entry/IPR011257 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW3518 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3518 KEGG_Gene eco:b3549 http://www.genome.jp/dbget-bin/www_bget?eco:b3549 KEGG_Orthology KO:K01246 http://www.genome.jp/dbget-bin/www_bget?KO:K01246 KEGG_Pathway ko03410 http://www.genome.jp/kegg-bin/show_pathway?ko03410 MINT MINT-1230071 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1230071 OMA FCGPTIV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FCGPTIV PDB 1LMZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1LMZ PDB 1NKU http://www.ebi.ac.uk/pdbe-srv/view/entry/1NKU PDB 1P7M http://www.ebi.ac.uk/pdbe-srv/view/entry/1P7M PDBsum 1LMZ http://www.ebi.ac.uk/pdbsum/1LMZ PDBsum 1NKU http://www.ebi.ac.uk/pdbsum/1NKU PDBsum 1P7M http://www.ebi.ac.uk/pdbsum/1P7M PSORT swissprot:3MG1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:3MG1_ECOLI PSORT-B swissprot:3MG1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:3MG1_ECOLI PSORT2 swissprot:3MG1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:3MG1_ECOLI Pfam PF03352 http://pfam.xfam.org/family/PF03352 Phobius swissprot:3MG1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:3MG1_ECOLI PhylomeDB P05100 http://phylomedb.org/?seqid=P05100 ProteinModelPortal P05100 http://www.proteinmodelportal.org/query/uniprot/P05100 PubMed 12161745 http://www.ncbi.nlm.nih.gov/pubmed/12161745 PubMed 12654914 http://www.ncbi.nlm.nih.gov/pubmed/12654914 PubMed 13129925 http://www.ncbi.nlm.nih.gov/pubmed/13129925 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3520491 http://www.ncbi.nlm.nih.gov/pubmed/3520491 PubMed 3536912 http://www.ncbi.nlm.nih.gov/pubmed/3536912 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_418005 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418005 RefSeq WP_000438957 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000438957 SMR P05100 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P05100 STRING 511145.b3549 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3549&targetmode=cogs STRING COG2818 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2818&targetmode=cogs SUPFAM SSF48150 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48150 TIGRFAMs TIGR00624 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00624 UniProtKB 3MG1_ECOLI http://www.uniprot.org/uniprot/3MG1_ECOLI UniProtKB-AC P05100 http://www.uniprot.org/uniprot/P05100 charge swissprot:3MG1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:3MG1_ECOLI eggNOG COG2818 http://eggnogapi.embl.de/nog_data/html/tree/COG2818 eggNOG ENOG4108R3E http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108R3E epestfind swissprot:3MG1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:3MG1_ECOLI garnier swissprot:3MG1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:3MG1_ECOLI helixturnhelix swissprot:3MG1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:3MG1_ECOLI hmoment swissprot:3MG1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:3MG1_ECOLI iep swissprot:3MG1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:3MG1_ECOLI inforesidue swissprot:3MG1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:3MG1_ECOLI octanol swissprot:3MG1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:3MG1_ECOLI pepcoil swissprot:3MG1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:3MG1_ECOLI pepdigest swissprot:3MG1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:3MG1_ECOLI pepinfo swissprot:3MG1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:3MG1_ECOLI pepnet swissprot:3MG1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:3MG1_ECOLI pepstats swissprot:3MG1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:3MG1_ECOLI pepwheel swissprot:3MG1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:3MG1_ECOLI pepwindow swissprot:3MG1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:3MG1_ECOLI sigcleave swissprot:3MG1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:3MG1_ECOLI ## Database ID URL or Descriptions # AltName HYBF_ECOLI Hydrogenase-2 operon protein HybF # BioGrid 4261537 5 # EcoGene EG11804 hybF # FUNCTION HYBF_ECOLI Probably plays a role in a hydrogenase nickel cofactor insertion step. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_function GO:0016151 nickel cation binding; IDA:EcoCyc. # GO_process GO:0006464 cellular protein modification process; IEA:UniProtKB-HAMAP. # GO_process GO:0051604 protein maturation; IMP:EcoCyc. # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0051604 protein maturation # HAMAP MF_00213 HypA # InterPro IPR000688 Hydgase_Ni_incorp_HypA/HybF # InterPro IPR020538 Hydgase_Ni_incorp_HypA/HybF_CS # Organism HYBF_ECOLI Escherichia coli (strain K12) # PATRIC 32121398 VBIEscCol129921_3086 # PIR F55516 F55516 # PIRSF PIRSF004761 Hydrgn_mat_HypA # PROSITE PS01249 HYPA # Pfam PF01155 HypA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HYBF_ECOLI Probable hydrogenase nickel incorporation protein HybF # RefSeq NP_417465 NC_000913.3 # RefSeq WP_000544953 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA21594.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the HypA/HybF family. {ECO 0000305}. # TIGRFAMs TIGR00100 hypA # eggNOG COG0375 LUCA # eggNOG ENOG4105WMM Bacteria BLAST swissprot:HYBF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HYBF_ECOLI BioCyc ECOL316407:JW5493-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5493-MONOMER BioCyc EcoCyc:EG11804-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11804-MONOMER COG COG0375 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0375 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U09177 http://www.ebi.ac.uk/ena/data/view/U09177 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB1752 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1752 EcoGene EG11804 http://www.ecogene.org/geneInfo.php?eg_id=EG11804 EnsemblBacteria AAC76027 http://www.ensemblgenomes.org/id/AAC76027 EnsemblBacteria AAC76027 http://www.ensemblgenomes.org/id/AAC76027 EnsemblBacteria BAE77052 http://www.ensemblgenomes.org/id/BAE77052 EnsemblBacteria BAE77052 http://www.ensemblgenomes.org/id/BAE77052 EnsemblBacteria BAE77052 http://www.ensemblgenomes.org/id/BAE77052 EnsemblBacteria b2991 http://www.ensemblgenomes.org/id/b2991 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0016151 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016151 GO_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GO_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 GeneID 948004 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948004 HAMAP MF_00213 http://hamap.expasy.org/unirule/MF_00213 HOGENOM HOG000291317 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000291317&db=HOGENOM6 InParanoid P0A703 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A703 IntAct P0A703 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A703* InterPro IPR000688 http://www.ebi.ac.uk/interpro/entry/IPR000688 InterPro IPR020538 http://www.ebi.ac.uk/interpro/entry/IPR020538 KEGG_Gene ecj:JW5493 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5493 KEGG_Gene eco:b2991 http://www.genome.jp/dbget-bin/www_bget?eco:b2991 KEGG_Orthology KO:K04651 http://www.genome.jp/dbget-bin/www_bget?KO:K04651 OMA MHEMSLC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MHEMSLC PROSITE PS01249 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01249 PSORT swissprot:HYBF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HYBF_ECOLI PSORT-B swissprot:HYBF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HYBF_ECOLI PSORT2 swissprot:HYBF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HYBF_ECOLI Pfam PF01155 http://pfam.xfam.org/family/PF01155 Phobius swissprot:HYBF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HYBF_ECOLI PhylomeDB P0A703 http://phylomedb.org/?seqid=P0A703 ProteinModelPortal P0A703 http://www.proteinmodelportal.org/query/uniprot/P0A703 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8021226 http://www.ncbi.nlm.nih.gov/pubmed/8021226 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417465 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417465 RefSeq WP_000544953 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000544953 SMR P0A703 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A703 STRING 511145.b2991 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2991&targetmode=cogs STRING COG0375 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0375&targetmode=cogs TIGRFAMs TIGR00100 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00100 UniProtKB HYBF_ECOLI http://www.uniprot.org/uniprot/HYBF_ECOLI UniProtKB-AC P0A703 http://www.uniprot.org/uniprot/P0A703 charge swissprot:HYBF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HYBF_ECOLI eggNOG COG0375 http://eggnogapi.embl.de/nog_data/html/tree/COG0375 eggNOG ENOG4105WMM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105WMM epestfind swissprot:HYBF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HYBF_ECOLI garnier swissprot:HYBF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HYBF_ECOLI helixturnhelix swissprot:HYBF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HYBF_ECOLI hmoment swissprot:HYBF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HYBF_ECOLI iep swissprot:HYBF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HYBF_ECOLI inforesidue swissprot:HYBF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HYBF_ECOLI octanol swissprot:HYBF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HYBF_ECOLI pepcoil swissprot:HYBF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HYBF_ECOLI pepdigest swissprot:HYBF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HYBF_ECOLI pepinfo swissprot:HYBF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HYBF_ECOLI pepnet swissprot:HYBF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HYBF_ECOLI pepstats swissprot:HYBF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HYBF_ECOLI pepwheel swissprot:HYBF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HYBF_ECOLI pepwindow swissprot:HYBF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HYBF_ECOLI sigcleave swissprot:HYBF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HYBF_ECOLI ## Database ID URL or Descriptions # BioGrid 4259305 20 # EcoGene EG12509 ytfI # Organism YTFI_ECOLI Escherichia coli (strain K12) # PATRIC 32124005 VBIEscCol129921_4347 # PIR S56440 S56440 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YTFI_ECOLI Uncharacterized protein YtfI # RefSeq WP_000937655 NZ_CP014272.1 # RefSeq YP_026285 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA97111.1; Type=Frameshift; Positions=134; Evidence={ECO 0000305}; BLAST swissprot:YTFI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YTFI_ECOLI BioCyc ECOL316407:JW5748-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5748-MONOMER BioCyc EcoCyc:G7870-MONOMER http://biocyc.org/getid?id=EcoCyc:G7870-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2402 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2402 EcoGene EG12509 http://www.ecogene.org/geneInfo.php?eg_id=EG12509 EnsemblBacteria AAT48243 http://www.ensemblgenomes.org/id/AAT48243 EnsemblBacteria AAT48243 http://www.ensemblgenomes.org/id/AAT48243 EnsemblBacteria BAE78216 http://www.ensemblgenomes.org/id/BAE78216 EnsemblBacteria BAE78216 http://www.ensemblgenomes.org/id/BAE78216 EnsemblBacteria BAE78216 http://www.ensemblgenomes.org/id/BAE78216 EnsemblBacteria b4215 http://www.ensemblgenomes.org/id/b4215 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 948738 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948738 HOGENOM HOG000054874 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000054874&db=HOGENOM6 KEGG_Gene ecj:JW5748 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5748 KEGG_Gene eco:b4215 http://www.genome.jp/dbget-bin/www_bget?eco:b4215 OMA WEFFRCA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WEFFRCA PSORT swissprot:YTFI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YTFI_ECOLI PSORT-B swissprot:YTFI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YTFI_ECOLI PSORT2 swissprot:YTFI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YTFI_ECOLI Phobius swissprot:YTFI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YTFI_ECOLI ProteinModelPortal P39317 http://www.proteinmodelportal.org/query/uniprot/P39317 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000937655 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000937655 RefSeq YP_026285 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026285 SMR P39317 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39317 STRING 511145.b4215 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4215&targetmode=cogs UniProtKB YTFI_ECOLI http://www.uniprot.org/uniprot/YTFI_ECOLI UniProtKB-AC P39317 http://www.uniprot.org/uniprot/P39317 charge swissprot:YTFI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YTFI_ECOLI epestfind swissprot:YTFI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YTFI_ECOLI garnier swissprot:YTFI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YTFI_ECOLI helixturnhelix swissprot:YTFI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YTFI_ECOLI hmoment swissprot:YTFI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YTFI_ECOLI iep swissprot:YTFI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YTFI_ECOLI inforesidue swissprot:YTFI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YTFI_ECOLI octanol swissprot:YTFI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YTFI_ECOLI pepcoil swissprot:YTFI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YTFI_ECOLI pepdigest swissprot:YTFI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YTFI_ECOLI pepinfo swissprot:YTFI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YTFI_ECOLI pepnet swissprot:YTFI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YTFI_ECOLI pepstats swissprot:YTFI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YTFI_ECOLI pepwheel swissprot:YTFI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YTFI_ECOLI pepwindow swissprot:YTFI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YTFI_ECOLI sigcleave swissprot:YTFI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YTFI_ECOLI ## Database ID URL or Descriptions # BioGrid 4259497 7 # EcoGene EG13267 allS # FUNCTION ALLS_ECOLI Positive regulator essential for the expression of allD operon. Binds to the allD promoter. {ECO 0000269|PubMed 12460564}. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IDA:EcoCyc. # GO_function GO:0043565 sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # INDUCTION Induced anaerobically and by nitrogen limitation. Repressed by AllR. {ECO:0000269|PubMed 12460564}. # IntAct P0ACR0 4 # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR005119 LysR_subst-bd # InterPro IPR011991 WHTH_DNA-bd_dom # KEGG_Brite ko03000 Transcription factors # Organism ALLS_ECOLI Escherichia coli (strain K12) # PATRIC 32116167 VBIEscCol129921_0525 # PIR G64781 G64781 # PROSITE PS50931 HTH_LYSR # Pfam PF00126 HTH_1 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ALLS_ECOLI HTH-type transcriptional activator AllS # RefSeq NP_415037 NC_000913.3 # RefSeq WP_000460145 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lysR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00253}. # SUPFAM SSF46785 SSF46785 # eggNOG ENOG4107653 Bacteria # eggNOG ENOG410XWA5 LUCA BLAST swissprot:ALLS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ALLS_ECOLI BioCyc ECOL316407:JW0492-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0492-MONOMER BioCyc EcoCyc:G6274-MONOMER http://biocyc.org/getid?id=EcoCyc:G6274-MONOMER COG COG0583 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0583 DOI 10.1016/S0022-2836(02)01134-8 http://dx.doi.org/10.1016/S0022-2836(02)01134-8 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL U89024 http://www.ebi.ac.uk/ena/data/view/U89024 EchoBASE EB3053 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3053 EcoGene EG13267 http://www.ecogene.org/geneInfo.php?eg_id=EG13267 EnsemblBacteria AAC73606 http://www.ensemblgenomes.org/id/AAC73606 EnsemblBacteria AAC73606 http://www.ensemblgenomes.org/id/AAC73606 EnsemblBacteria BAE76282 http://www.ensemblgenomes.org/id/BAE76282 EnsemblBacteria BAE76282 http://www.ensemblgenomes.org/id/BAE76282 EnsemblBacteria BAE76282 http://www.ensemblgenomes.org/id/BAE76282 EnsemblBacteria b0504 http://www.ensemblgenomes.org/id/b0504 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 945139 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945139 HOGENOM HOG000181312 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000181312&db=HOGENOM6 InParanoid P0ACR0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACR0 IntAct P0ACR0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACR0* InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW0492 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0492 KEGG_Gene eco:b0504 http://www.genome.jp/dbget-bin/www_bget?eco:b0504 KEGG_Orthology KO:K10972 http://www.genome.jp/dbget-bin/www_bget?KO:K10972 OMA VYMGVWD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VYMGVWD PROSITE PS50931 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50931 PSORT swissprot:ALLS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ALLS_ECOLI PSORT-B swissprot:ALLS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ALLS_ECOLI PSORT2 swissprot:ALLS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ALLS_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:ALLS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ALLS_ECOLI PhylomeDB P0ACR0 http://phylomedb.org/?seqid=P0ACR0 ProteinModelPortal P0ACR0 http://www.proteinmodelportal.org/query/uniprot/P0ACR0 PubMed 10601204 http://www.ncbi.nlm.nih.gov/pubmed/10601204 PubMed 12460564 http://www.ncbi.nlm.nih.gov/pubmed/12460564 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415037 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415037 RefSeq WP_000460145 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000460145 SMR P0ACR0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACR0 STRING 511145.b0504 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0504&targetmode=cogs STRING COG0583 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0583&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB ALLS_ECOLI http://www.uniprot.org/uniprot/ALLS_ECOLI UniProtKB-AC P0ACR0 http://www.uniprot.org/uniprot/P0ACR0 charge swissprot:ALLS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ALLS_ECOLI eggNOG ENOG4107653 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107653 eggNOG ENOG410XWA5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XWA5 epestfind swissprot:ALLS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ALLS_ECOLI garnier swissprot:ALLS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ALLS_ECOLI helixturnhelix swissprot:ALLS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ALLS_ECOLI hmoment swissprot:ALLS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ALLS_ECOLI iep swissprot:ALLS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ALLS_ECOLI inforesidue swissprot:ALLS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ALLS_ECOLI octanol swissprot:ALLS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ALLS_ECOLI pepcoil swissprot:ALLS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ALLS_ECOLI pepdigest swissprot:ALLS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ALLS_ECOLI pepinfo swissprot:ALLS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ALLS_ECOLI pepnet swissprot:ALLS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ALLS_ECOLI pepstats swissprot:ALLS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ALLS_ECOLI pepwheel swissprot:ALLS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ALLS_ECOLI pepwindow swissprot:ALLS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ALLS_ECOLI sigcleave swissprot:ALLS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ALLS_ECOLI ## Database ID URL or Descriptions # BioGrid 4259662 102 # EcoGene EG12570 kptA # FUNCTION KPTA_ECOLI Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP- ribosylase. {ECO 0000269|PubMed 9915792}. # GO_function GO:0016772 transferase activity, transferring phosphorus-containing groups; IDA:EcoCyc. # GO_function GO:0016773 phosphotransferase activity, alcohol group as acceptor; IEA:InterPro. # GO_process GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation; IEA:UniProtKB-HAMAP. # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006399 tRNA metabolic process # HAMAP MF_00299 KptA # IntAct P39380 3 # InterPro IPR002745 Ptrans_KptA/Tpt1 # InterPro IPR022928 RNA_2'-PTrans_KptA # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # Organism KPTA_ECOLI Escherichia coli (strain K12) # PATRIC 32124266 VBIEscCol129921_4476 # PIR S56556 S56556 # Pfam PF01885 PTS_2-RNA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName KPTA_ECOLI RNA 2'-phosphotransferase # RefSeq NP_418751 NC_000913.3 # RefSeq WP_001151855 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97227.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the KptA/TPT1 family. {ECO 0000305}. # eggNOG COG1859 LUCA # eggNOG ENOG4108UMS Bacteria BLAST swissprot:KPTA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:KPTA_ECOLI BioCyc ECOL316407:JW5784-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5784-MONOMER BioCyc EcoCyc:G7928-MONOMER http://biocyc.org/getid?id=EcoCyc:G7928-MONOMER COG COG1859 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1859 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.274.5.2637 http://dx.doi.org/10.1074/jbc.274.5.2637 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 2.7.1.- http://enzyme.expasy.org/EC/2.7.1.- EchoBASE EB2458 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2458 EcoGene EG12570 http://www.ecogene.org/geneInfo.php?eg_id=EG12570 EnsemblBacteria AAC77287 http://www.ensemblgenomes.org/id/AAC77287 EnsemblBacteria AAC77287 http://www.ensemblgenomes.org/id/AAC77287 EnsemblBacteria BAE78324 http://www.ensemblgenomes.org/id/BAE78324 EnsemblBacteria BAE78324 http://www.ensemblgenomes.org/id/BAE78324 EnsemblBacteria BAE78324 http://www.ensemblgenomes.org/id/BAE78324 EnsemblBacteria b4331 http://www.ensemblgenomes.org/id/b4331 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016772 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016772 GO_function GO:0016773 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016773 GO_process GO:0006388 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006388 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GeneID 948858 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948858 HAMAP MF_00299 http://hamap.expasy.org/unirule/MF_00299 HOGENOM HOG000229875 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000229875&db=HOGENOM6 InParanoid P39380 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39380 IntAct P39380 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39380* IntEnz 2.7.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1 InterPro IPR002745 http://www.ebi.ac.uk/interpro/entry/IPR002745 InterPro IPR022928 http://www.ebi.ac.uk/interpro/entry/IPR022928 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW5784 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5784 KEGG_Gene eco:b4331 http://www.genome.jp/dbget-bin/www_bget?eco:b4331 KEGG_Orthology KO:K07559 http://www.genome.jp/dbget-bin/www_bget?KO:K07559 OMA SANGVWL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SANGVWL PSORT swissprot:KPTA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:KPTA_ECOLI PSORT-B swissprot:KPTA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:KPTA_ECOLI PSORT2 swissprot:KPTA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:KPTA_ECOLI Pfam PF01885 http://pfam.xfam.org/family/PF01885 Phobius swissprot:KPTA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:KPTA_ECOLI PhylomeDB P39380 http://phylomedb.org/?seqid=P39380 ProteinModelPortal P39380 http://www.proteinmodelportal.org/query/uniprot/P39380 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9915792 http://www.ncbi.nlm.nih.gov/pubmed/9915792 RefSeq NP_418751 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418751 RefSeq WP_001151855 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001151855 SMR P39380 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39380 STRING 511145.b4331 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4331&targetmode=cogs STRING COG1859 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1859&targetmode=cogs UniProtKB KPTA_ECOLI http://www.uniprot.org/uniprot/KPTA_ECOLI UniProtKB-AC P39380 http://www.uniprot.org/uniprot/P39380 charge swissprot:KPTA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:KPTA_ECOLI eggNOG COG1859 http://eggnogapi.embl.de/nog_data/html/tree/COG1859 eggNOG ENOG4108UMS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UMS epestfind swissprot:KPTA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:KPTA_ECOLI garnier swissprot:KPTA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:KPTA_ECOLI helixturnhelix swissprot:KPTA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:KPTA_ECOLI hmoment swissprot:KPTA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:KPTA_ECOLI iep swissprot:KPTA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:KPTA_ECOLI inforesidue swissprot:KPTA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:KPTA_ECOLI octanol swissprot:KPTA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:KPTA_ECOLI pepcoil swissprot:KPTA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:KPTA_ECOLI pepdigest swissprot:KPTA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:KPTA_ECOLI pepinfo swissprot:KPTA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:KPTA_ECOLI pepnet swissprot:KPTA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:KPTA_ECOLI pepstats swissprot:KPTA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:KPTA_ECOLI pepwheel swissprot:KPTA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:KPTA_ECOLI pepwindow swissprot:KPTA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:KPTA_ECOLI sigcleave swissprot:KPTA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:KPTA_ECOLI ## Database ID URL or Descriptions # AltName ECPA_ECOLI MatB fimbrillin # BioGrid 4259792 22 # EcoGene EG13565 ecpA # FUNCTION ECPA_ECOLI Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition. Major subunit of the fimbria (By similarity). {ECO 0000250}. # GO_component GO:0009289 pilus; IEA:UniProtKB-SubCell. # GOslim_component GO:0005575 cellular_component # INDUCTION Negatively regulated by H-NS. Positively regulated by IHF and EcpR (By similarity). {ECO 0000250}. # InterPro IPR016514 MatB # MISCELLANEOUS Not expressed under classical laboratory conditions, but is functional when constitutively expressed (PubMed:11466275 and PubMed 20522494). # Organism ECPA_ECOLI Escherichia coli (strain K12) # PATRIC 32115709 VBIEscCol129921_0297 # PIR E64755 E64755 # PIRSF PIRSF007320 Fimbrillin_MatB # Pfam PF16449 MatB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ECPA_ECOLI Common pilus major fimbrillin subunit EcpA # RefSeq NP_414827 NC_000913.3 # RefSeq WP_000730972 NZ_LN832404.1 # SIMILARITY Belongs to the EcpA/MatB fimbrillin family. {ECO 0000305}. # SUBCELLULAR LOCATION ECPA_ECOLI Fimbrium {ECO 0000250}. # SUBUNIT Self-associates. Forms filaments. Interacts with EcpD (By similarity). {ECO 0000250}. # eggNOG ENOG4108GWT Bacteria # eggNOG ENOG410ZQ0F LUCA BLAST swissprot:ECPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ECPA_ECOLI BioCyc ECOL316407:JW0287-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0287-MONOMER BioCyc EcoCyc:G6164-MONOMER http://biocyc.org/getid?id=EcoCyc:G6164-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1099/mic.0.039610-0 http://dx.doi.org/10.1099/mic.0.039610-0 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.183.16.4727-4736.2001 http://dx.doi.org/10.1128/JB.183.16.4727-4736.2001 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB3335 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3335 EcoGene EG13565 http://www.ecogene.org/geneInfo.php?eg_id=EG13565 EnsemblBacteria AAC73396 http://www.ensemblgenomes.org/id/AAC73396 EnsemblBacteria AAC73396 http://www.ensemblgenomes.org/id/AAC73396 EnsemblBacteria BAE76077 http://www.ensemblgenomes.org/id/BAE76077 EnsemblBacteria BAE76077 http://www.ensemblgenomes.org/id/BAE76077 EnsemblBacteria BAE76077 http://www.ensemblgenomes.org/id/BAE76077 EnsemblBacteria b0293 http://www.ensemblgenomes.org/id/b0293 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009289 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GeneID 948759 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948759 HOGENOM HOG000269503 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000269503&db=HOGENOM6 InterPro IPR016514 http://www.ebi.ac.uk/interpro/entry/IPR016514 KEGG_Gene ecj:JW0287 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0287 KEGG_Gene eco:b0293 http://www.genome.jp/dbget-bin/www_bget?eco:b0293 OMA ATWKATA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ATWKATA PSORT swissprot:ECPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ECPA_ECOLI PSORT-B swissprot:ECPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ECPA_ECOLI PSORT2 swissprot:ECPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ECPA_ECOLI Pfam PF16449 http://pfam.xfam.org/family/PF16449 Phobius swissprot:ECPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ECPA_ECOLI ProteinModelPortal P0AAA3 http://www.proteinmodelportal.org/query/uniprot/P0AAA3 PubMed 11466275 http://www.ncbi.nlm.nih.gov/pubmed/11466275 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20522494 http://www.ncbi.nlm.nih.gov/pubmed/20522494 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414827 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414827 RefSeq WP_000730972 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000730972 SMR P0AAA3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAA3 STRING 511145.b0293 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0293&targetmode=cogs UniProtKB ECPA_ECOLI http://www.uniprot.org/uniprot/ECPA_ECOLI UniProtKB-AC P0AAA3 http://www.uniprot.org/uniprot/P0AAA3 charge swissprot:ECPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ECPA_ECOLI eggNOG ENOG4108GWT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108GWT eggNOG ENOG410ZQ0F http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZQ0F epestfind swissprot:ECPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ECPA_ECOLI garnier swissprot:ECPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ECPA_ECOLI helixturnhelix swissprot:ECPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ECPA_ECOLI hmoment swissprot:ECPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ECPA_ECOLI iep swissprot:ECPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ECPA_ECOLI inforesidue swissprot:ECPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ECPA_ECOLI octanol swissprot:ECPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ECPA_ECOLI pepcoil swissprot:ECPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ECPA_ECOLI pepdigest swissprot:ECPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ECPA_ECOLI pepinfo swissprot:ECPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ECPA_ECOLI pepnet swissprot:ECPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ECPA_ECOLI pepstats swissprot:ECPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ECPA_ECOLI pepwheel swissprot:ECPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ECPA_ECOLI pepwindow swissprot:ECPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ECPA_ECOLI sigcleave swissprot:ECPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ECPA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260625 4 # EcoGene EG13202 yfjP # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003924 GTPase activity; IBA:GO_Central. # GO_function GO:0005525 GTP binding; IBA:GO_Central. # GO_function GO:0043022 ribosome binding; IBA:GO_Central. # GO_process GO:0000027 ribosomal large subunit assembly; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003924 GTPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0022618 ribonucleoprotein complex assembly # Gene3D 3.40.50.300 -; 2. # InterPro IPR006073 GTP_binding_domain # InterPro IPR027417 P-loop_NTPase # Organism YFJP_ECOLI Escherichia coli (strain K12) # PATRIC 32120655 VBIEscCol129921_2726 # Pfam PF01926 MMR_HSR1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFJP_ECOLI Uncharacterized protein YfjP # RefSeq WP_000787597 NZ_LN832404.1 # RefSeq YP_026173 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA79801.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Contains 1 G (guanine nucleotide-binding) domain. {ECO 0000305}. # SIMILARITY To E.coli YkfA and YeeP. {ECO 0000305}. # SUPFAM SSF52540 SSF52540 # eggNOG COG3596 LUCA # eggNOG ENOG4105TS0 Bacteria BLAST swissprot:YFJP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFJP_ECOLI BioCyc ECOL316407:JW5419-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5419-MONOMER BioCyc EcoCyc:G7367-MONOMER http://biocyc.org/getid?id=EcoCyc:G7367-MONOMER COG COG3596 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3596 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36840 http://www.ebi.ac.uk/ena/data/view/U36840 EchoBASE EB2994 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2994 EcoGene EG13202 http://www.ecogene.org/geneInfo.php?eg_id=EG13202 EnsemblBacteria AAT48146 http://www.ensemblgenomes.org/id/AAT48146 EnsemblBacteria AAT48146 http://www.ensemblgenomes.org/id/AAT48146 EnsemblBacteria BAE76767 http://www.ensemblgenomes.org/id/BAE76767 EnsemblBacteria BAE76767 http://www.ensemblgenomes.org/id/BAE76767 EnsemblBacteria BAE76767 http://www.ensemblgenomes.org/id/BAE76767 EnsemblBacteria b2632 http://www.ensemblgenomes.org/id/b2632 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_function GO:0043022 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043022 GO_process GO:0000027 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000027 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0022618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022618 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947124 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947124 HOGENOM HOG000121786 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000121786&db=HOGENOM6 InParanoid P52131 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P52131 InterPro IPR006073 http://www.ebi.ac.uk/interpro/entry/IPR006073 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Gene ecj:JW5419 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5419 KEGG_Gene eco:b2632 http://www.genome.jp/dbget-bin/www_bget?eco:b2632 KEGG_Orthology KO:K06946 http://www.genome.jp/dbget-bin/www_bget?KO:K06946 OMA LEPCHEW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LEPCHEW PSORT swissprot:YFJP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFJP_ECOLI PSORT-B swissprot:YFJP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFJP_ECOLI PSORT2 swissprot:YFJP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFJP_ECOLI Pfam PF01926 http://pfam.xfam.org/family/PF01926 Phobius swissprot:YFJP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFJP_ECOLI PhylomeDB P52131 http://phylomedb.org/?seqid=P52131 ProteinModelPortal P52131 http://www.proteinmodelportal.org/query/uniprot/P52131 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000787597 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000787597 RefSeq YP_026173 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026173 SMR P52131 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P52131 STRING 511145.b2632 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2632&targetmode=cogs STRING COG3596 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3596&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB YFJP_ECOLI http://www.uniprot.org/uniprot/YFJP_ECOLI UniProtKB-AC P52131 http://www.uniprot.org/uniprot/P52131 charge swissprot:YFJP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFJP_ECOLI eggNOG COG3596 http://eggnogapi.embl.de/nog_data/html/tree/COG3596 eggNOG ENOG4105TS0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105TS0 epestfind swissprot:YFJP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFJP_ECOLI garnier swissprot:YFJP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFJP_ECOLI helixturnhelix swissprot:YFJP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFJP_ECOLI hmoment swissprot:YFJP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFJP_ECOLI iep swissprot:YFJP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFJP_ECOLI inforesidue swissprot:YFJP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFJP_ECOLI octanol swissprot:YFJP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFJP_ECOLI pepcoil swissprot:YFJP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFJP_ECOLI pepdigest swissprot:YFJP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFJP_ECOLI pepinfo swissprot:YFJP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFJP_ECOLI pepnet swissprot:YFJP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFJP_ECOLI pepstats swissprot:YFJP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFJP_ECOLI pepwheel swissprot:YFJP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFJP_ECOLI pepwindow swissprot:YFJP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFJP_ECOLI sigcleave swissprot:YFJP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFJP_ECOLI ## Database ID URL or Descriptions # BioGrid 4261469 126 # EcoGene EG12720 ygjI # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0015179 L-amino acid transmembrane transporter activity; IBA:GO_Central. # GO_function GO:0015297 antiporter activity; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # InterPro IPR002293 AA/rel_permease1 # Organism YGJI_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11785 PTHR11785 # PATRIC 32121572 VBIEscCol129921_3172 # PIR C65096 C65096 # PIRSF PIRSF006060 AA_transporter # Pfam PF13520 AA_permease_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGJI_ECOLI Inner membrane transporter YgjI # RefSeq WP_001285432 NZ_LN832404.1 # RefSeq YP_026200 NC_000913.3 # SIMILARITY Belongs to the amino acid-polyamine-organocation (APC) superfamily. {ECO 0000305}. # SUBCELLULAR LOCATION YGJI_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.3.7 the amino acid-polyamine-organocation (apc) family # eggNOG COG0531 LUCA # eggNOG ENOG4105E5D Bacteria BLAST swissprot:YGJI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGJI_ECOLI BioCyc ECOL316407:JW5512-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5512-MONOMER BioCyc EcoCyc:YGJI-MONOMER http://biocyc.org/getid?id=EcoCyc:YGJI-MONOMER DIP DIP-12235N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12235N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2579 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2579 EcoGene EG12720 http://www.ecogene.org/geneInfo.php?eg_id=EG12720 EnsemblBacteria AAT48165 http://www.ensemblgenomes.org/id/AAT48165 EnsemblBacteria AAT48165 http://www.ensemblgenomes.org/id/AAT48165 EnsemblBacteria BAE77128 http://www.ensemblgenomes.org/id/BAE77128 EnsemblBacteria BAE77128 http://www.ensemblgenomes.org/id/BAE77128 EnsemblBacteria BAE77128 http://www.ensemblgenomes.org/id/BAE77128 EnsemblBacteria b3078 http://www.ensemblgenomes.org/id/b3078 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015179 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015179 GO_function GO:0015297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015297 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GeneID 947579 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947579 HOGENOM HOG000269875 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000269875&db=HOGENOM6 InParanoid P42590 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P42590 IntAct P42590 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P42590* InterPro IPR002293 http://www.ebi.ac.uk/interpro/entry/IPR002293 KEGG_Gene ecj:JW5512 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5512 KEGG_Gene eco:b3078 http://www.genome.jp/dbget-bin/www_bget?eco:b3078 MINT MINT-1310596 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1310596 OMA LWTAAPV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LWTAAPV PANTHER PTHR11785 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11785 PSORT swissprot:YGJI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGJI_ECOLI PSORT-B swissprot:YGJI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGJI_ECOLI PSORT2 swissprot:YGJI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGJI_ECOLI Pfam PF13520 http://pfam.xfam.org/family/PF13520 Phobius swissprot:YGJI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGJI_ECOLI PhylomeDB P42590 http://phylomedb.org/?seqid=P42590 ProteinModelPortal P42590 http://www.proteinmodelportal.org/query/uniprot/P42590 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001285432 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001285432 RefSeq YP_026200 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026200 STRING 511145.b3078 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3078&targetmode=cogs TCDB 2.A.3.7 http://www.tcdb.org/search/result.php?tc=2.A.3.7 UniProtKB YGJI_ECOLI http://www.uniprot.org/uniprot/YGJI_ECOLI UniProtKB-AC P42590 http://www.uniprot.org/uniprot/P42590 charge swissprot:YGJI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGJI_ECOLI eggNOG COG0531 http://eggnogapi.embl.de/nog_data/html/tree/COG0531 eggNOG ENOG4105E5D http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E5D epestfind swissprot:YGJI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGJI_ECOLI garnier swissprot:YGJI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGJI_ECOLI helixturnhelix swissprot:YGJI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGJI_ECOLI hmoment swissprot:YGJI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGJI_ECOLI iep swissprot:YGJI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGJI_ECOLI inforesidue swissprot:YGJI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGJI_ECOLI octanol swissprot:YGJI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGJI_ECOLI pepcoil swissprot:YGJI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGJI_ECOLI pepdigest swissprot:YGJI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGJI_ECOLI pepinfo swissprot:YGJI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGJI_ECOLI pepnet swissprot:YGJI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGJI_ECOLI pepstats swissprot:YGJI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGJI_ECOLI pepwheel swissprot:YGJI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGJI_ECOLI pepwindow swissprot:YGJI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGJI_ECOLI sigcleave swissprot:YGJI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGJI_ECOLI ## Database ID URL or Descriptions # BioGrid 4260519 71 # EcoGene EG14111 yfcH # GO_function GO:0003824 catalytic activity; IEA:InterPro. # GO_function GO:0050662 coenzyme binding; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # Gene3D 3.40.50.720 -; 1. # IntAct P77775 8 # InterPro IPR001509 Epimerase_deHydtase # InterPro IPR010099 SDR39U1 # InterPro IPR013549 DUF1731 # InterPro IPR016040 NAD(P)-bd_dom # Organism YFCH_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11092 PTHR11092 # PATRIC 32119979 VBIEscCol129921_2399 # PIR F65002 F65002 # Pfam PF01370 Epimerase # Pfam PF08338 DUF1731 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFCH_ECOLI Epimerase family protein YfcH # RefSeq NP_416807 NC_000913.3 # RefSeq WP_001028341 NZ_LN832404.1 # SIMILARITY Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily. {ECO 0000305}. # SUPFAM SSF51735 SSF51735 # TIGRFAMs TIGR01777 yfcH # eggNOG COG1090 LUCA # eggNOG ENOG4105ECP Bacteria BLAST swissprot:YFCH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFCH_ECOLI BioCyc ECOL316407:JW2301-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2301-MONOMER BioCyc EcoCyc:G7196-MONOMER http://biocyc.org/getid?id=EcoCyc:G7196-MONOMER COG COG1090 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1090 DIP DIP-11981N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11981N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3864 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3864 EcoGene EG14111 http://www.ecogene.org/geneInfo.php?eg_id=EG14111 EnsemblBacteria AAC75364 http://www.ensemblgenomes.org/id/AAC75364 EnsemblBacteria AAC75364 http://www.ensemblgenomes.org/id/AAC75364 EnsemblBacteria BAA16141 http://www.ensemblgenomes.org/id/BAA16141 EnsemblBacteria BAA16141 http://www.ensemblgenomes.org/id/BAA16141 EnsemblBacteria BAA16141 http://www.ensemblgenomes.org/id/BAA16141 EnsemblBacteria b2304 http://www.ensemblgenomes.org/id/b2304 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003824 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003824 GO_function GO:0050662 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050662 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 946784 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946784 HOGENOM HOG000029190 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000029190&db=HOGENOM6 InParanoid P77775 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77775 IntAct P77775 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77775* InterPro IPR001509 http://www.ebi.ac.uk/interpro/entry/IPR001509 InterPro IPR010099 http://www.ebi.ac.uk/interpro/entry/IPR010099 InterPro IPR013549 http://www.ebi.ac.uk/interpro/entry/IPR013549 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 KEGG_Gene ecj:JW2301 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2301 KEGG_Gene eco:b2304 http://www.genome.jp/dbget-bin/www_bget?eco:b2304 KEGG_Orthology KO:K07071 http://www.genome.jp/dbget-bin/www_bget?KO:K07071 OMA NVWNSRI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NVWNSRI PANTHER PTHR11092 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11092 PSORT swissprot:YFCH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFCH_ECOLI PSORT-B swissprot:YFCH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFCH_ECOLI PSORT2 swissprot:YFCH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFCH_ECOLI Pfam PF01370 http://pfam.xfam.org/family/PF01370 Pfam PF08338 http://pfam.xfam.org/family/PF08338 Phobius swissprot:YFCH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFCH_ECOLI PhylomeDB P77775 http://phylomedb.org/?seqid=P77775 ProteinModelPortal P77775 http://www.proteinmodelportal.org/query/uniprot/P77775 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416807 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416807 RefSeq WP_001028341 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001028341 SMR P77775 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77775 STRING 511145.b2304 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2304&targetmode=cogs STRING COG1090 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1090&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 TIGRFAMs TIGR01777 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01777 UniProtKB YFCH_ECOLI http://www.uniprot.org/uniprot/YFCH_ECOLI UniProtKB-AC P77775 http://www.uniprot.org/uniprot/P77775 charge swissprot:YFCH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFCH_ECOLI eggNOG COG1090 http://eggnogapi.embl.de/nog_data/html/tree/COG1090 eggNOG ENOG4105ECP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ECP epestfind swissprot:YFCH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFCH_ECOLI garnier swissprot:YFCH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFCH_ECOLI helixturnhelix swissprot:YFCH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFCH_ECOLI hmoment swissprot:YFCH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFCH_ECOLI iep swissprot:YFCH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFCH_ECOLI inforesidue swissprot:YFCH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFCH_ECOLI octanol swissprot:YFCH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFCH_ECOLI pepcoil swissprot:YFCH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFCH_ECOLI pepdigest swissprot:YFCH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFCH_ECOLI pepinfo swissprot:YFCH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFCH_ECOLI pepnet swissprot:YFCH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFCH_ECOLI pepstats swissprot:YFCH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFCH_ECOLI pepwheel swissprot:YFCH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFCH_ECOLI pepwindow swissprot:YFCH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFCH_ECOLI sigcleave swissprot:YFCH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFCH_ECOLI ## Database ID URL or Descriptions # BRENDA 1.14.99.46 2026 # BioGrid 4260038 22 # CATALYTIC ACTIVITY Thymine + FMNH(2) + O(2) = (Z)-2- methylureidoacrylate peracid + FMN + H(2)O. {ECO:0000269|PubMed 20369853}. # CATALYTIC ACTIVITY Uracil + FMNH(2) + O(2) = (Z)-3-ureidoacrylate peracid + FMN + H(2)O. {ECO:0000269|PubMed 20369853}. # DISRUPTION PHENOTYPE Cells lacking this gene lose the ability to utilize pyrimidine nucleosides and bases as the sole source of nitrogen at room temperature. {ECO:0000269|PubMed 16540542}. # EcoGene EG13859 rutA # FUNCTION RUTA_ECOLI Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate. Requires the flavin reductase RutF to regenerate FMN in vivo. RutF can be substituted by Fre in vitro. {ECO 0000269|PubMed 16540542, ECO 0000269|PubMed 20400551}. # GO_function GO:0004497 monooxygenase activity; IDA:UniProtKB. # GO_function GO:0008726 alkanesulfonate monooxygenase activity; IBA:GO_Central. # GO_function GO:0052614 uracil oxygenase activity; IDA:CACAO. # GO_process GO:0006208 pyrimidine nucleobase catabolic process; IMP:EcoCyc. # GO_process GO:0006210 thymine catabolic process; IDA:CACAO. # GO_process GO:0006212 uracil catabolic process; IDA:UniProtKB. # GO_process GO:0019740 nitrogen utilization; IDA:UniProtKB. # GO_process GO:0046306 alkanesulfonate catabolic process; IBA:GO_Central. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.30 -; 1. # HAMAP MF_01699 RutA # INDUCTION RUTA_ECOLI Up-regulated by the nitrogen regulatory protein C (NtrC also called GlnG) and repressed by RutR. {ECO 0000269|PubMed 11121068, ECO 0000269|PubMed 17919280}. # IntAct P75898 7 # InterPro IPR011251 Luciferase-like_dom # InterPro IPR019914 Pyrimidine_monooxygenase_RutA # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00240 Pyrimidine metabolism # MISCELLANEOUS RUTA_ECOLI The Rut pathway degrades exogenous pyrimidines as the sole nitrogen source at room temperature but not at 37 degrees Celsius, a restriction that is apparently a consequence of an inadequate ability to remove toxic malonic semialdehyde at the higher temperature (RutE/YdfG function). # Organism RUTA_ECOLI Escherichia coli (strain K12) # PATRIC 32117253 VBIEscCol129921_1050 # PIR B64843 B64843 # Pfam PF00296 Bac_luciferase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RUTA_ECOLI Pyrimidine monooxygenase RutA # RefSeq NP_415532 NC_000913.3 # SIMILARITY Belongs to the NtaA/SnaA/SoxA(DszA) monooxygenase family. RutA subfamily. {ECO 0000305}. # SUPFAM SSF51679 SSF51679 # TIGRFAMs TIGR03612 RutA # eggNOG COG2141 LUCA # eggNOG ENOG4105EQP Bacteria BLAST swissprot:RUTA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RUTA_ECOLI BioCyc ECOL316407:JW0997-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0997-MONOMER BioCyc EcoCyc:G6523-MONOMER http://biocyc.org/getid?id=EcoCyc:G6523-MONOMER BioCyc MetaCyc:G6523-MONOMER http://biocyc.org/getid?id=MetaCyc:G6523-MONOMER COG COG2141 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2141 DOI 10.1021/ja9107676 http://dx.doi.org/10.1021/ja9107676 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0600521103 http://dx.doi.org/10.1073/pnas.0600521103 DOI 10.1073/pnas.97.26.14674 http://dx.doi.org/10.1073/pnas.97.26.14674 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.2007.05954.x http://dx.doi.org/10.1111/j.1365-2958.2007.05954.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00201-10 http://dx.doi.org/10.1128/JB.00201-10 EC_number EC:1.14.99.46 http://www.genome.jp/dbget-bin/www_bget?EC:1.14.99.46 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.14.99.46 http://enzyme.expasy.org/EC/1.14.99.46 EchoBASE EB3619 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3619 EcoGene EG13859 http://www.ecogene.org/geneInfo.php?eg_id=EG13859 EnsemblBacteria AAC74097 http://www.ensemblgenomes.org/id/AAC74097 EnsemblBacteria AAC74097 http://www.ensemblgenomes.org/id/AAC74097 EnsemblBacteria BAA35789 http://www.ensemblgenomes.org/id/BAA35789 EnsemblBacteria BAA35789 http://www.ensemblgenomes.org/id/BAA35789 EnsemblBacteria BAA35789 http://www.ensemblgenomes.org/id/BAA35789 EnsemblBacteria b1012 http://www.ensemblgenomes.org/id/b1012 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004497 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004497 GO_function GO:0008726 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008726 GO_function GO:0052614 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052614 GO_process GO:0006208 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006208 GO_process GO:0006210 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006210 GO_process GO:0006212 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006212 GO_process GO:0019740 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019740 GO_process GO:0046306 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046306 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.30 http://www.cathdb.info/version/latest/superfamily/3.20.20.30 GeneID 945643 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945643 HAMAP MF_01699 http://hamap.expasy.org/unirule/MF_01699 HOGENOM HOG000268769 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000268769&db=HOGENOM6 InParanoid P75898 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75898 IntAct P75898 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75898* IntEnz 1.14.99.46 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.14.99.46 InterPro IPR011251 http://www.ebi.ac.uk/interpro/entry/IPR011251 InterPro IPR019914 http://www.ebi.ac.uk/interpro/entry/IPR019914 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0997 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0997 KEGG_Gene eco:b1012 http://www.genome.jp/dbget-bin/www_bget?eco:b1012 KEGG_Orthology KO:K09018 http://www.genome.jp/dbget-bin/www_bget?KO:K09018 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Reaction rn:R09936 http://www.genome.jp/dbget-bin/www_bget?rn:R09936 OMA ADYNFCF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ADYNFCF PSORT swissprot:RUTA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RUTA_ECOLI PSORT-B swissprot:RUTA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RUTA_ECOLI PSORT2 swissprot:RUTA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RUTA_ECOLI Pfam PF00296 http://pfam.xfam.org/family/PF00296 Phobius swissprot:RUTA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RUTA_ECOLI PhylomeDB P75898 http://phylomedb.org/?seqid=P75898 ProteinModelPortal P75898 http://www.proteinmodelportal.org/query/uniprot/P75898 PubMed 11121068 http://www.ncbi.nlm.nih.gov/pubmed/11121068 PubMed 16540542 http://www.ncbi.nlm.nih.gov/pubmed/16540542 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17919280 http://www.ncbi.nlm.nih.gov/pubmed/17919280 PubMed 20369853 http://www.ncbi.nlm.nih.gov/pubmed/20369853 PubMed 20400551 http://www.ncbi.nlm.nih.gov/pubmed/20400551 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415532 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415532 STRING 511145.b1012 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1012&targetmode=cogs STRING COG2141 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2141&targetmode=cogs SUPFAM SSF51679 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51679 TIGRFAMs TIGR03612 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03612 UniProtKB RUTA_ECOLI http://www.uniprot.org/uniprot/RUTA_ECOLI UniProtKB-AC P75898 http://www.uniprot.org/uniprot/P75898 charge swissprot:RUTA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RUTA_ECOLI eggNOG COG2141 http://eggnogapi.embl.de/nog_data/html/tree/COG2141 eggNOG ENOG4105EQP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EQP epestfind swissprot:RUTA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RUTA_ECOLI garnier swissprot:RUTA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RUTA_ECOLI helixturnhelix swissprot:RUTA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RUTA_ECOLI hmoment swissprot:RUTA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RUTA_ECOLI iep swissprot:RUTA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RUTA_ECOLI inforesidue swissprot:RUTA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RUTA_ECOLI octanol swissprot:RUTA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RUTA_ECOLI pepcoil swissprot:RUTA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RUTA_ECOLI pepdigest swissprot:RUTA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RUTA_ECOLI pepinfo swissprot:RUTA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RUTA_ECOLI pepnet swissprot:RUTA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RUTA_ECOLI pepstats swissprot:RUTA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RUTA_ECOLI pepwheel swissprot:RUTA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RUTA_ECOLI pepwindow swissprot:RUTA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RUTA_ECOLI sigcleave swissprot:RUTA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RUTA_ECOLI ## Database ID URL or Descriptions # FUNCTION TRAF_ECOLI Involved in F pilus assembly. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_process GO:0000746 conjugation; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0008150 biological_process # InterPro IPR014110 TraF # Organism TRAF_ECOLI Escherichia coli (strain K12) # PIR A31099 QUECTF # RecName TRAF_ECOLI Protein TraF # RefSeq NP_061470 NC_002483.1 # RefSeq WP_001030367 NZ_CP014273.1 # RefSeq WP_002433298 NC_002483.1 # RefSeq YP_009060141 NC_024956.1 # RefSeq YP_009068333 NC_025139.1 # RefSeq YP_009070598 NC_025175.1 # SEQUENCE CAUTION Sequence=BAA97961.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SUBCELLULAR LOCATION TRAF_ECOLI Periplasm. # TIGRFAMs TIGR02739 TraF BLAST swissprot:TRAF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRAF_ECOLI DIP DIP-28100N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-28100N DOI 10.1016/0022-2836(92)90923-8 http://dx.doi.org/10.1016/0022-2836(92)90923-8 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL M20787 http://www.ebi.ac.uk/ena/data/view/M20787 EMBL U01159 http://www.ebi.ac.uk/ena/data/view/U01159 EMBL X61575 http://www.ebi.ac.uk/ena/data/view/X61575 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_process GO:0000746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000746 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 1263589 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263589 GeneID 20466894 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20466894 GeneID 20491463 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20491463 GeneID 20492666 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20492666 InterPro IPR014110 http://www.ebi.ac.uk/interpro/entry/IPR014110 OMA MLTTFCH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MLTTFCH PSORT swissprot:TRAF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRAF_ECOLI PSORT-B swissprot:TRAF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRAF_ECOLI PSORT2 swissprot:TRAF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRAF_ECOLI Phobius swissprot:TRAF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRAF_ECOLI ProteinModelPortal P14497 http://www.proteinmodelportal.org/query/uniprot/P14497 PubMed 1593622 http://www.ncbi.nlm.nih.gov/pubmed/1593622 PubMed 3042757 http://www.ncbi.nlm.nih.gov/pubmed/3042757 PubMed 7915817 http://www.ncbi.nlm.nih.gov/pubmed/7915817 RefSeq NP_061470 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061470 RefSeq WP_001030367 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001030367 RefSeq WP_002433298 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_002433298 RefSeq YP_009060141 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009060141 RefSeq YP_009068333 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009068333 RefSeq YP_009070598 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009070598 SMR P14497 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P14497 TIGRFAMs TIGR02739 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02739 UniProtKB TRAF_ECOLI http://www.uniprot.org/uniprot/TRAF_ECOLI UniProtKB-AC P14497 http://www.uniprot.org/uniprot/P14497 charge swissprot:TRAF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRAF_ECOLI epestfind swissprot:TRAF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRAF_ECOLI garnier swissprot:TRAF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRAF_ECOLI helixturnhelix swissprot:TRAF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRAF_ECOLI hmoment swissprot:TRAF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRAF_ECOLI iep swissprot:TRAF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRAF_ECOLI inforesidue swissprot:TRAF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRAF_ECOLI octanol swissprot:TRAF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRAF_ECOLI pepcoil swissprot:TRAF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRAF_ECOLI pepdigest swissprot:TRAF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRAF_ECOLI pepinfo swissprot:TRAF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRAF_ECOLI pepnet swissprot:TRAF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRAF_ECOLI pepstats swissprot:TRAF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRAF_ECOLI pepwheel swissprot:TRAF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRAF_ECOLI pepwindow swissprot:TRAF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRAF_ECOLI sigcleave swissprot:TRAF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRAF_ECOLI ## Database ID URL or Descriptions # BioGrid 4260776 698 # CAUTION The modification on Lys-34 was initially thought to be a spermidine residue. {ECO:0000305|PubMed 18201202}. # CDD cd04470 S1_EF-P_repeat_1 # CDD cd05794 S1_EF-P_repeat_2 # DISRUPTION PHENOTYPE EFP_ECOLI Disruption of this gene leads to lethality (PubMed 9405429) or to a very slow growth phenotype (PubMed 20729861). Required for the expression of poly-Pro- containing proteins. {ECO 0000269|PubMed 20729861, ECO 0000269|PubMed 23239623, ECO 0000269|PubMed 9405429}. # EcoGene EG12099 efp # FUNCTION EFP_ECOLI Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Beta-lysylation at Lys-34 is required for alleviation. The Pro codons and their context do not affect activity; only consecutive Pro residues (not another amino acid) are affected by EF-P. Has stimulatory effects on peptide bond formation between ribosome-bound initiator tRNA(fMet) and puromycin, and N-acetyl-Phe tRNA(Phe)-primed poly(U)-directed poly(Phe) synthesis. {ECO 0000269|PubMed 23239623, ECO 0000269|PubMed 23239624}. # GO_component GO:0005737 cytoplasm; IDA:EcoCyc. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003746 translation elongation factor activity; IDA:EcoCyc. # GO_function GO:0043022 ribosome binding; IDA:EcoCyc. # GO_process GO:0006414 translational elongation; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008135 translation factor activity, RNA binding # GOslim_process GO:0009058 biosynthetic process # Gene3D 2.30.30.30 -; 1. # HAMAP MF_00141 EF_P # InterPro IPR001059 Transl_elong_P/YeiP_cen # InterPro IPR008991 Translation_prot_SH3-like # InterPro IPR011768 Transl_elongation_fac_P # InterPro IPR012340 NA-bd_OB-fold # InterPro IPR013185 Transl_elong_KOW-like # InterPro IPR013852 Transl_elong_P/YeiP_CS # InterPro IPR014722 Rib_L2_dom2 # InterPro IPR015365 Elong-fact-P_C # InterPro IPR020599 Transl_elong_fac_P/YeiP # KEGG_Brite ko03012 Translation factors # MASS SPECTROMETRY Mass=20591.6; Method=Electrospray; Range=2-188; Note=With N6-(3,6-diaminohexanoyl)-5-hydroxy-Lys-34.; Evidence={ECO:0000269|PubMed 22706199}; # Organism EFP_ECOLI Escherichia coli (strain K12) # PATHWAY EFP_ECOLI Protein biosynthesis; polypeptide chain elongation. # PATRIC 32123863 VBIEscCol129921_4279 # PDB 3A5Z X-ray; 2.50 A; B/D/F/H=1-188 # PIR S34443 S34443 # PIRSF PIRSF005901 EF-P # PROSITE PS01275 EFP # PTM EFP_ECOLI Is beta-lysylated on the epsilon-amino group of Lys-34 by the combined action of EpmA and EpmB, and then hydroxylated on the C5 position of the same residue by EpmC. Lysylation is critical for the stimulatory effect of EF-P on peptide-bond formation. The lysylation moiety would extend toward the peptidyltransferase center and stabilize the terminal 3-CCA end of the tRNA. The hydroxylation of the C5 position on Lys-34 would allow additional potential stabilizing hydrogen-bond interactions with the P-tRNA (PubMed 21841797 PubMed 22128152 PubMed 22706199 and PubMed 20729861). {ECO 0000269|PubMed 21841797, ECO 0000269|PubMed 22128152, ECO 0000269|PubMed 22706199}. # Pfam PF01132 EFP # Pfam PF08207 EFP_N # Pfam PF09285 Elong-fact-P_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EFP_ECOLI Elongation factor P # RefSeq NP_418571 NC_000913.3 # RefSeq WP_000257278 NZ_LN832404.1 # SIMILARITY Belongs to the elongation factor P family. {ECO 0000305}. # SMART SM00841 Elong-fact-P_C # SMART SM01185 EFP # SUBCELLULAR LOCATION EFP_ECOLI Cytoplasm. # SUBUNIT Binds 30S, 50S and 70S ribosomes, possibly near the A site, note that T.thermophilus structures show binding between the P and E sites (PDB 3HUW and 3HUY). Proportionally less EF-P binds to larger polysomes, suggesting it has a role early in translation. It is present in 1 copy per 10 ribosomes. {ECO:0000269|PubMed 20729861}. # SUPFAM SSF50104 SSF50104 # SUPFAM SSF50249 SSF50249; 2 # TIGRFAMs TIGR00038 efp # eggNOG COG0231 LUCA # eggNOG ENOG4105DRH Bacteria BLAST swissprot:EFP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EFP_ECOLI BioCyc ECOL316407:JW4107-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4107-MONOMER BioCyc EcoCyc:EG12099-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12099-MONOMER BioCyc MetaCyc:EG12099-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12099-MONOMER COG COG0231 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0231 DIP DIP-31834N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31834N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1016/S0300-9084(97)87619-5 http://dx.doi.org/10.1016/S0300-9084(97)87619-5 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nchembio.1001 http://dx.doi.org/10.1038/nchembio.1001 DOI 10.1038/nchembio.632 http://dx.doi.org/10.1038/nchembio.632 DOI 10.1038/nsmb.1889 http://dx.doi.org/10.1038/nsmb.1889 DOI 10.1074/jbc.272.51.32254 http://dx.doi.org/10.1074/jbc.272.51.32254 DOI 10.1074/jbc.M111.309633 http://dx.doi.org/10.1074/jbc.M111.309633 DOI 10.1093/nar/19.22.6215 http://dx.doi.org/10.1093/nar/19.22.6215 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1111/j.1742-4658.2007.06228.x http://dx.doi.org/10.1111/j.1742-4658.2007.06228.x DOI 10.1126/science.1228985 http://dx.doi.org/10.1126/science.1228985 DOI 10.1126/science.1229017 http://dx.doi.org/10.1126/science.1229017 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X61676 http://www.ebi.ac.uk/ena/data/view/X61676 EchoBASE EB2023 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2023 EcoGene EG12099 http://www.ecogene.org/geneInfo.php?eg_id=EG12099 EnsemblBacteria AAC77107 http://www.ensemblgenomes.org/id/AAC77107 EnsemblBacteria AAC77107 http://www.ensemblgenomes.org/id/AAC77107 EnsemblBacteria BAE78149 http://www.ensemblgenomes.org/id/BAE78149 EnsemblBacteria BAE78149 http://www.ensemblgenomes.org/id/BAE78149 EnsemblBacteria BAE78149 http://www.ensemblgenomes.org/id/BAE78149 EnsemblBacteria b4147 http://www.ensemblgenomes.org/id/b4147 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003746 GO_function GO:0043022 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043022 GO_process GO:0006414 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006414 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008135 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008135 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 2.30.30.30 http://www.cathdb.info/version/latest/superfamily/2.30.30.30 GeneID 948661 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948661 HAMAP MF_00141 http://hamap.expasy.org/unirule/MF_00141 HOGENOM HOG000010047 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000010047&db=HOGENOM6 InParanoid P0A6N4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6N4 IntAct P0A6N4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6N4* InterPro IPR001059 http://www.ebi.ac.uk/interpro/entry/IPR001059 InterPro IPR008991 http://www.ebi.ac.uk/interpro/entry/IPR008991 InterPro IPR011768 http://www.ebi.ac.uk/interpro/entry/IPR011768 InterPro IPR012340 http://www.ebi.ac.uk/interpro/entry/IPR012340 InterPro IPR013185 http://www.ebi.ac.uk/interpro/entry/IPR013185 InterPro IPR013852 http://www.ebi.ac.uk/interpro/entry/IPR013852 InterPro IPR014722 http://www.ebi.ac.uk/interpro/entry/IPR014722 InterPro IPR015365 http://www.ebi.ac.uk/interpro/entry/IPR015365 InterPro IPR020599 http://www.ebi.ac.uk/interpro/entry/IPR020599 KEGG_Brite ko03012 http://www.genome.jp/dbget-bin/www_bget?ko03012 KEGG_Gene ecj:JW4107 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4107 KEGG_Gene eco:b4147 http://www.genome.jp/dbget-bin/www_bget?eco:b4147 KEGG_Orthology KO:K02356 http://www.genome.jp/dbget-bin/www_bget?KO:K02356 OMA DYVFMDM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DYVFMDM PDB 3A5Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3A5Z PDBsum 3A5Z http://www.ebi.ac.uk/pdbsum/3A5Z PROSITE PS01275 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01275 PSORT swissprot:EFP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EFP_ECOLI PSORT-B swissprot:EFP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EFP_ECOLI PSORT2 swissprot:EFP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EFP_ECOLI Pfam PF01132 http://pfam.xfam.org/family/PF01132 Pfam PF08207 http://pfam.xfam.org/family/PF08207 Pfam PF09285 http://pfam.xfam.org/family/PF09285 Phobius swissprot:EFP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EFP_ECOLI PhylomeDB P0A6N4 http://phylomedb.org/?seqid=P0A6N4 ProteinModelPortal P0A6N4 http://www.proteinmodelportal.org/query/uniprot/P0A6N4 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18201202 http://www.ncbi.nlm.nih.gov/pubmed/18201202 PubMed 1956781 http://www.ncbi.nlm.nih.gov/pubmed/1956781 PubMed 20729861 http://www.ncbi.nlm.nih.gov/pubmed/20729861 PubMed 21841797 http://www.ncbi.nlm.nih.gov/pubmed/21841797 PubMed 22128152 http://www.ncbi.nlm.nih.gov/pubmed/22128152 PubMed 22706199 http://www.ncbi.nlm.nih.gov/pubmed/22706199 PubMed 23239623 http://www.ncbi.nlm.nih.gov/pubmed/23239623 PubMed 23239624 http://www.ncbi.nlm.nih.gov/pubmed/23239624 PubMed 7011506 http://www.ncbi.nlm.nih.gov/pubmed/7011506 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9195040 http://www.ncbi.nlm.nih.gov/pubmed/9195040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9405429 http://www.ncbi.nlm.nih.gov/pubmed/9405429 RefSeq NP_418571 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418571 RefSeq WP_000257278 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000257278 SMART SM00841 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00841 SMART SM01185 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01185 SMR P0A6N4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6N4 STRING 511145.b4147 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4147&targetmode=cogs STRING COG0231 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0231&targetmode=cogs SUPFAM SSF50104 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50104 SUPFAM SSF50249 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50249 TIGRFAMs TIGR00038 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00038 UniProtKB EFP_ECOLI http://www.uniprot.org/uniprot/EFP_ECOLI UniProtKB-AC P0A6N4 http://www.uniprot.org/uniprot/P0A6N4 charge swissprot:EFP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EFP_ECOLI eggNOG COG0231 http://eggnogapi.embl.de/nog_data/html/tree/COG0231 eggNOG ENOG4105DRH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DRH epestfind swissprot:EFP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EFP_ECOLI garnier swissprot:EFP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EFP_ECOLI helixturnhelix swissprot:EFP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EFP_ECOLI hmoment swissprot:EFP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EFP_ECOLI iep swissprot:EFP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EFP_ECOLI inforesidue swissprot:EFP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EFP_ECOLI octanol swissprot:EFP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EFP_ECOLI pepcoil swissprot:EFP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EFP_ECOLI pepdigest swissprot:EFP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EFP_ECOLI pepinfo swissprot:EFP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EFP_ECOLI pepnet swissprot:EFP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EFP_ECOLI pepstats swissprot:EFP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EFP_ECOLI pepwheel swissprot:EFP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EFP_ECOLI pepwindow swissprot:EFP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EFP_ECOLI sigcleave swissprot:EFP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EFP_ECOLI ## Database ID URL or Descriptions # AltName Ascorbate-specific phosphotransferase enzyme IIB component {ECO:0000303|PubMed 12644495} # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=18 uM for L-ascorbate {ECO 0000269|PubMed:12644495}; # BioGrid 4262714 8 # CATALYTIC ACTIVITY [Protein]-N(pi)-phospho-L-histidine + L- ascorbate(Side 1) = [protein]-L-histidine + L-ascorbate 6- phosphate(Side 2). {ECO:0000269|PubMed 12644495}. # DISRUPTION PHENOTYPE Cells lacking this gene are unable to use L- ascorbate. {ECO:0000269|PubMed 12644495}. # DOMAIN ULAB_ECOLI The PTS EIIB type-2 domain is phosphorylated by phospho- EIIA on a cysteinyl residue. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the PTS EIIC type-2 domain. {ECO 0000255|PROSITE- ProRule PRU00422}. # EcoGene EG12494 ulaB # FUNCTION ULAB_ECOLI The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport. {ECO 0000269|PubMed 12644495, ECO 0000305|PubMed 11741871}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0008982 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:InterPro. # GO_function GO:0016301 kinase activity; IEA:UniProtKB-KW. # GO_function GO:0090585 protein-phosphocysteine-L-ascorbate-phosphotransferase system transporter activity; IMP:EcoCyc. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IDA:EcoCyc. # GO_process GO:0015882 L-ascorbic acid transport; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # INDUCTION ULAB_ECOLI Induced by L-ascorbate. Repressed by UlaR. {ECO 0000269|PubMed 12374842, ECO 0000269|PubMed 12644495, ECO 0000269|PubMed 14996803}. # IntAct P69822 5 # InterPro IPR003501 PTS_EIIB_2/3 # InterPro IPR013011 PTS_EIIB_2 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00283 PTS system, ascorbate-specific II component # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko00053 Ascorbate and aldarate metabolism # KEGG_Pathway ko02060 Phosphotransferase system (PTS) # Organism ULAB_ECOLI Escherichia coli (strain K12) # PATRIC 32123963 VBIEscCol129921_4326 # PIR S56419 S56419 # PROSITE PS51099 PTS_EIIB_TYPE_2 # Pfam PF02302 PTS_IIB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Ascorbate-specific PTS system EIIB component {ECO:0000303|PubMed 12644495} # RefSeq NP_418615 NC_000913.3 # RefSeq WP_000218362 NZ_LN832404.1 # SIMILARITY Contains 1 PTS EIIB type-2 domain. {ECO:0000255|PROSITE-ProRule PRU00422}. # SUBCELLULAR LOCATION ULAB_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF52794 SSF52794 # TCDB 4.A.7.1 the pts l-ascorbate (l-asc) family # eggNOG COG3414 LUCA # eggNOG ENOG410907W Bacteria BLAST swissprot:ULAB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ULAB_ECOLI BioCyc ECOL316407:JW4152-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4152-MONOMER BioCyc EcoCyc:YJFT-MONOMER http://biocyc.org/getid?id=EcoCyc:YJFT-MONOMER BioCyc MetaCyc:YJFT-MONOMER http://biocyc.org/getid?id=MetaCyc:YJFT-MONOMER COG COG3414 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3414 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.1.302-306.2002 http://dx.doi.org/10.1128/JB.184.1.302-306.2002 DOI 10.1128/JB.184.21.6065-6068.2002 http://dx.doi.org/10.1128/JB.184.21.6065-6068.2002 DOI 10.1128/JB.185.7.2243-2250.2003 http://dx.doi.org/10.1128/JB.185.7.2243-2250.2003 DOI 10.1128/JB.186.6.1720-1728.2004 http://dx.doi.org/10.1128/JB.186.6.1720-1728.2004 EC_number EC:2.7.1.194 {ECO:0000269|PubMed:12644495} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.194 {ECO:0000269|PubMed:12644495} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 2.7.1.194 {ECO:0000269|PubMed:12644495} http://enzyme.expasy.org/EC/2.7.1.194 {ECO:0000269|PubMed:12644495} EchoBASE EB2387 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2387 EcoGene EG12494 http://www.ecogene.org/geneInfo.php?eg_id=EG12494 EnsemblBacteria AAC77151 http://www.ensemblgenomes.org/id/AAC77151 EnsemblBacteria AAC77151 http://www.ensemblgenomes.org/id/AAC77151 EnsemblBacteria BAE78195 http://www.ensemblgenomes.org/id/BAE78195 EnsemblBacteria BAE78195 http://www.ensemblgenomes.org/id/BAE78195 EnsemblBacteria BAE78195 http://www.ensemblgenomes.org/id/BAE78195 EnsemblBacteria b4194 http://www.ensemblgenomes.org/id/b4194 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0008982 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008982 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_function GO:0090585 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090585 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GO_process GO:0015882 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015882 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948716 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948716 HOGENOM HOG000081922 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000081922&db=HOGENOM6 IntAct P69822 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69822* IntEnz 2.7.1.194 {ECO:0000269|PubMed:12644495} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.194 {ECO:0000269|PubMed:12644495} InterPro IPR003501 http://www.ebi.ac.uk/interpro/entry/IPR003501 InterPro IPR013011 http://www.ebi.ac.uk/interpro/entry/IPR013011 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW4152 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4152 KEGG_Gene eco:b4194 http://www.genome.jp/dbget-bin/www_bget?eco:b4194 KEGG_Orthology KO:K02822 http://www.genome.jp/dbget-bin/www_bget?KO:K02822 KEGG_Pathway ko00053 http://www.genome.jp/kegg-bin/show_pathway?ko00053 KEGG_Pathway ko02060 http://www.genome.jp/kegg-bin/show_pathway?ko02060 KEGG_Reaction rn:R07671 http://www.genome.jp/dbget-bin/www_bget?rn:R07671 OMA IVASTHV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IVASTHV PROSITE PS51099 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51099 PSORT swissprot:ULAB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ULAB_ECOLI PSORT-B swissprot:ULAB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ULAB_ECOLI PSORT2 swissprot:ULAB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ULAB_ECOLI Pfam PF02302 http://pfam.xfam.org/family/PF02302 Phobius swissprot:ULAB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ULAB_ECOLI ProteinModelPortal P69822 http://www.proteinmodelportal.org/query/uniprot/P69822 PubMed 11741871 http://www.ncbi.nlm.nih.gov/pubmed/11741871 PubMed 12374842 http://www.ncbi.nlm.nih.gov/pubmed/12374842 PubMed 12644495 http://www.ncbi.nlm.nih.gov/pubmed/12644495 PubMed 14996803 http://www.ncbi.nlm.nih.gov/pubmed/14996803 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418615 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418615 RefSeq WP_000218362 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000218362 SMR P69822 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69822 STRING 511145.b4194 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4194&targetmode=cogs STRING COG3414 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3414&targetmode=cogs SUPFAM SSF52794 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52794 TCDB 4.A.7.1 http://www.tcdb.org/search/result.php?tc=4.A.7.1 UniProtKB ULAB_ECOLI http://www.uniprot.org/uniprot/ULAB_ECOLI UniProtKB-AC P69822 http://www.uniprot.org/uniprot/P69822 charge swissprot:ULAB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ULAB_ECOLI eggNOG COG3414 http://eggnogapi.embl.de/nog_data/html/tree/COG3414 eggNOG ENOG410907W http://eggnogapi.embl.de/nog_data/html/tree/ENOG410907W epestfind swissprot:ULAB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ULAB_ECOLI garnier swissprot:ULAB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ULAB_ECOLI helixturnhelix swissprot:ULAB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ULAB_ECOLI hmoment swissprot:ULAB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ULAB_ECOLI iep swissprot:ULAB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ULAB_ECOLI inforesidue swissprot:ULAB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ULAB_ECOLI octanol swissprot:ULAB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ULAB_ECOLI pepcoil swissprot:ULAB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ULAB_ECOLI pepdigest swissprot:ULAB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ULAB_ECOLI pepinfo swissprot:ULAB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ULAB_ECOLI pepnet swissprot:ULAB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ULAB_ECOLI pepstats swissprot:ULAB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ULAB_ECOLI pepwheel swissprot:ULAB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ULAB_ECOLI pepwindow swissprot:ULAB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ULAB_ECOLI sigcleave swissprot:ULAB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ULAB_ECOLI ## Database ID URL or Descriptions # AltName PPIA_ECOLI Cyclophilin A # AltName PPIA_ECOLI Rotamase A # BioGrid 4261085 126 # CATALYTIC ACTIVITY PPIA_ECOLI Peptidylproline (omega=180) = peptidylproline (omega=0). # ENZYME REGULATION PPIA_ECOLI Inhibition by cyclosporin A with a Ki of 25 to 50 mu-mol, a concentration 100-fold higher than that required for eukaryotic PPIases. # EcoGene EG10757 ppiA # FUNCTION PPIA_ECOLI PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. {ECO 0000269|PubMed 2190212}. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0003755 peptidyl-prolyl cis-trans isomerase activity; IDA:EcoCyc. # GO_process GO:0006457 protein folding; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0006457 protein folding # Gene3D 2.40.100.10 -; 1. # InterPro IPR002130 Cyclophilin-type_PPIase_dom # InterPro IPR020892 Cyclophilin-type_PPIase_CS # InterPro IPR024936 Cyclophilin-type_PPIase # InterPro IPR029000 Cyclophilin-like_dom # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03110 Chaperones and folding catalysts # Organism PPIA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11071 PTHR11071 # PATRIC 32122160 VBIEscCol129921_3457 # PDB 1CLH NMR; -; A=25-190 # PDB 1J2A X-ray; 1.80 A; A=25-190 # PDB 1V9T X-ray; 1.70 A; A/B=25-190 # PDB 1VAI X-ray; 1.80 A; A/B=25-190 # PIR A37964 CSECA # PRINTS PR00153 CSAPPISMRASE # PROSITE PS00170 CSA_PPIASE_1 # PROSITE PS50072 CSA_PPIASE_2 # Pfam PF00160 Pro_isomerase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PPIA_ECOLI Peptidyl-prolyl cis-trans isomerase A # RefSeq NP_417822 NC_000913.3 # RefSeq WP_000477225 NZ_LN832404.1 # SIMILARITY Belongs to the cyclophilin-type PPIase family. {ECO 0000305}. # SIMILARITY Contains 1 PPIase cyclophilin-type domain. {ECO:0000255|PROSITE-ProRule PRU00156}. # SUBCELLULAR LOCATION PPIA_ECOLI Periplasm. # SUPFAM SSF50891 SSF50891 # eggNOG COG0652 LUCA # eggNOG ENOG4108R5K Bacteria BLAST swissprot:PPIA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PPIA_ECOLI BioCyc ECOL316407:JW3326-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3326-MONOMER BioCyc EcoCyc:EG10757-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10757-MONOMER BioCyc MetaCyc:EG10757-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10757-MONOMER COG COG0652 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0652 DIP DIP-48080N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48080N DOI 10.1021/bi00176a004 http://dx.doi.org/10.1021/bi00176a004 DOI 10.1021/bi00185a007 http://dx.doi.org/10.1021/bi00185a007 DOI 10.1021/bi00223a003 http://dx.doi.org/10.1021/bi00223a003 DOI 10.1021/bi00226a009 http://dx.doi.org/10.1021/bi00226a009 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.87.11.4028 http://dx.doi.org/10.1073/pnas.87.11.4028 DOI 10.1111/j.1432-1033.1992.tb17002.x http://dx.doi.org/10.1111/j.1432-1033.1992.tb17002.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.2.1.8 http://www.genome.jp/dbget-bin/www_bget?EC:5.2.1.8 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M28363 http://www.ebi.ac.uk/ena/data/view/M28363 EMBL M32354 http://www.ebi.ac.uk/ena/data/view/M32354 EMBL M55429 http://www.ebi.ac.uk/ena/data/view/M55429 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 5.2.1.8 http://enzyme.expasy.org/EC/5.2.1.8 EchoBASE EB0750 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0750 EcoGene EG10757 http://www.ecogene.org/geneInfo.php?eg_id=EG10757 EnsemblBacteria AAC76388 http://www.ensemblgenomes.org/id/AAC76388 EnsemblBacteria AAC76388 http://www.ensemblgenomes.org/id/AAC76388 EnsemblBacteria BAE77927 http://www.ensemblgenomes.org/id/BAE77927 EnsemblBacteria BAE77927 http://www.ensemblgenomes.org/id/BAE77927 EnsemblBacteria BAE77927 http://www.ensemblgenomes.org/id/BAE77927 EnsemblBacteria b3363 http://www.ensemblgenomes.org/id/b3363 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0003755 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003755 GO_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 Gene3D 2.40.100.10 http://www.cathdb.info/version/latest/superfamily/2.40.100.10 GeneID 947870 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947870 HOGENOM HOG000065978 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000065978&db=HOGENOM6 InParanoid P0AFL3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFL3 IntEnz 5.2.1.8 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.2.1.8 InterPro IPR002130 http://www.ebi.ac.uk/interpro/entry/IPR002130 InterPro IPR020892 http://www.ebi.ac.uk/interpro/entry/IPR020892 InterPro IPR024936 http://www.ebi.ac.uk/interpro/entry/IPR024936 InterPro IPR029000 http://www.ebi.ac.uk/interpro/entry/IPR029000 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW3326 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3326 KEGG_Gene eco:b3363 http://www.genome.jp/dbget-bin/www_bget?eco:b3363 KEGG_Orthology KO:K03767 http://www.genome.jp/dbget-bin/www_bget?KO:K03767 OMA RDMKEKP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RDMKEKP PANTHER PTHR11071 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11071 PDB 1CLH http://www.ebi.ac.uk/pdbe-srv/view/entry/1CLH PDB 1J2A http://www.ebi.ac.uk/pdbe-srv/view/entry/1J2A PDB 1V9T http://www.ebi.ac.uk/pdbe-srv/view/entry/1V9T PDB 1VAI http://www.ebi.ac.uk/pdbe-srv/view/entry/1VAI PDBsum 1CLH http://www.ebi.ac.uk/pdbsum/1CLH PDBsum 1J2A http://www.ebi.ac.uk/pdbsum/1J2A PDBsum 1V9T http://www.ebi.ac.uk/pdbsum/1V9T PDBsum 1VAI http://www.ebi.ac.uk/pdbsum/1VAI PRINTS PR00153 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00153 PROSITE PS00170 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00170 PROSITE PS50072 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50072 PSORT swissprot:PPIA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PPIA_ECOLI PSORT-B swissprot:PPIA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PPIA_ECOLI PSORT2 swissprot:PPIA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PPIA_ECOLI Pfam PF00160 http://pfam.xfam.org/family/PF00160 Phobius swissprot:PPIA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PPIA_ECOLI PhylomeDB P0AFL3 http://phylomedb.org/?seqid=P0AFL3 ProteinModelPortal P0AFL3 http://www.proteinmodelportal.org/query/uniprot/P0AFL3 PubMed 1606970 http://www.ncbi.nlm.nih.gov/pubmed/1606970 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2001362 http://www.ncbi.nlm.nih.gov/pubmed/2001362 PubMed 2007139 http://www.ncbi.nlm.nih.gov/pubmed/2007139 PubMed 2190212 http://www.ncbi.nlm.nih.gov/pubmed/2190212 PubMed 2403545 http://www.ncbi.nlm.nih.gov/pubmed/2403545 PubMed 2546924 http://www.ncbi.nlm.nih.gov/pubmed/2546924 PubMed 8130188 http://www.ncbi.nlm.nih.gov/pubmed/8130188 PubMed 8180197 http://www.ncbi.nlm.nih.gov/pubmed/8180197 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417822 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417822 RefSeq WP_000477225 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000477225 SMR P0AFL3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFL3 STRING 511145.b3363 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3363&targetmode=cogs STRING COG0652 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0652&targetmode=cogs SUPFAM SSF50891 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50891 SWISS-2DPAGE P0AFL3 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AFL3 UniProtKB PPIA_ECOLI http://www.uniprot.org/uniprot/PPIA_ECOLI UniProtKB-AC P0AFL3 http://www.uniprot.org/uniprot/P0AFL3 charge swissprot:PPIA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PPIA_ECOLI eggNOG COG0652 http://eggnogapi.embl.de/nog_data/html/tree/COG0652 eggNOG ENOG4108R5K http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108R5K epestfind swissprot:PPIA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PPIA_ECOLI garnier swissprot:PPIA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PPIA_ECOLI helixturnhelix swissprot:PPIA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PPIA_ECOLI hmoment swissprot:PPIA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PPIA_ECOLI iep swissprot:PPIA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PPIA_ECOLI inforesidue swissprot:PPIA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PPIA_ECOLI octanol swissprot:PPIA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PPIA_ECOLI pepcoil swissprot:PPIA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PPIA_ECOLI pepdigest swissprot:PPIA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PPIA_ECOLI pepinfo swissprot:PPIA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PPIA_ECOLI pepnet swissprot:PPIA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PPIA_ECOLI pepstats swissprot:PPIA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PPIA_ECOLI pepwheel swissprot:PPIA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PPIA_ECOLI pepwindow swissprot:PPIA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PPIA_ECOLI sigcleave swissprot:PPIA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PPIA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259121 139 # CDD cd06174 MFS # EcoGene EG12951 ynfM # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005215 transporter activity; IEA:InterPro. # GO_process GO:0055085 transmembrane transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0055085 transmembrane transport # InterPro IPR005829 Sugar_transporter_CS # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # KEGG_Brite ko02000 Transporters # Organism YNFM_ECOLI Escherichia coli (strain K12) # PATRIC 32118494 VBIEscCol129921_1667 # PIR F64915 F64915 # PROSITE PS00216 SUGAR_TRANSPORT_1 # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNFM_ECOLI Inner membrane transport protein YnfM # RefSeq NP_416113 NC_000913.3 # RefSeq WP_000091840 NZ_LN832404.1 # SIMILARITY Belongs to the major facilitator superfamily. {ECO 0000305}. # SUBCELLULAR LOCATION YNFM_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.36 the major facilitator superfamily (mfs) # eggNOG ENOG4105D94 Bacteria # eggNOG ENOG410XP8J LUCA BLAST swissprot:YNFM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNFM_ECOLI BioCyc ECOL316407:JW1588-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1588-MONOMER BioCyc EcoCyc:B1596-MONOMER http://biocyc.org/getid?id=EcoCyc:B1596-MONOMER COG COG0477 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0477 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AF405541 http://www.ebi.ac.uk/ena/data/view/AF405541 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2785 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2785 EcoGene EG12951 http://www.ecogene.org/geneInfo.php?eg_id=EG12951 EnsemblBacteria AAC74668 http://www.ensemblgenomes.org/id/AAC74668 EnsemblBacteria AAC74668 http://www.ensemblgenomes.org/id/AAC74668 EnsemblBacteria BAA15330 http://www.ensemblgenomes.org/id/BAA15330 EnsemblBacteria BAA15330 http://www.ensemblgenomes.org/id/BAA15330 EnsemblBacteria BAA15330 http://www.ensemblgenomes.org/id/BAA15330 EnsemblBacteria b1596 http://www.ensemblgenomes.org/id/b1596 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 946138 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946138 HOGENOM HOG000217197 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000217197&db=HOGENOM6 InParanoid P43531 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P43531 InterPro IPR005829 http://www.ebi.ac.uk/interpro/entry/IPR005829 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1588 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1588 KEGG_Gene eco:b1596 http://www.genome.jp/dbget-bin/www_bget?eco:b1596 KEGG_Orthology KO:K08224 http://www.genome.jp/dbget-bin/www_bget?KO:K08224 OMA NFRLHWH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NFRLHWH PROSITE PS00216 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00216 PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:YNFM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNFM_ECOLI PSORT-B swissprot:YNFM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNFM_ECOLI PSORT2 swissprot:YNFM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNFM_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:YNFM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNFM_ECOLI PhylomeDB P43531 http://phylomedb.org/?seqid=P43531 ProteinModelPortal P43531 http://www.proteinmodelportal.org/query/uniprot/P43531 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416113 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416113 RefSeq WP_000091840 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000091840 STRING 511145.b1596 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1596&targetmode=cogs STRING COG0477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0477&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.36 http://www.tcdb.org/search/result.php?tc=2.A.1.36 UniProtKB YNFM_ECOLI http://www.uniprot.org/uniprot/YNFM_ECOLI UniProtKB-AC P43531 http://www.uniprot.org/uniprot/P43531 charge swissprot:YNFM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNFM_ECOLI eggNOG ENOG4105D94 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D94 eggNOG ENOG410XP8J http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XP8J epestfind swissprot:YNFM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNFM_ECOLI garnier swissprot:YNFM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNFM_ECOLI helixturnhelix swissprot:YNFM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNFM_ECOLI hmoment swissprot:YNFM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNFM_ECOLI iep swissprot:YNFM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNFM_ECOLI inforesidue swissprot:YNFM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNFM_ECOLI octanol swissprot:YNFM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNFM_ECOLI pepcoil swissprot:YNFM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNFM_ECOLI pepdigest swissprot:YNFM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNFM_ECOLI pepinfo swissprot:YNFM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNFM_ECOLI pepnet swissprot:YNFM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNFM_ECOLI pepstats swissprot:YNFM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNFM_ECOLI pepwheel swissprot:YNFM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNFM_ECOLI pepwindow swissprot:YNFM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNFM_ECOLI sigcleave swissprot:YNFM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNFM_ECOLI ## Database ID URL or Descriptions # AltName GUTQ_ECOLI Phosphosugar aldol-ketol isomerase # BIOPHYSICOCHEMICAL PROPERTIES GUTQ_ECOLI Kinetic parameters KM=0.64 mM for Ru5P (at pH 8.25 and at 37 degrees Celsius) {ECO 0000269|PubMed 16199563}; KM=1.2 mM for A5P (at pH 8.25 and at 37 degrees Celsius) {ECO 0000269|PubMed 16199563}; pH dependence Optimum pH is 8.25. {ECO 0000269|PubMed 16199563}; # BioGrid 4263273 290 # CATALYTIC ACTIVITY GUTQ_ECOLI D-arabinose 5-phosphate = D-ribulose 5- phosphate. # EcoGene EG10973 gutQ # FUNCTION GUTQ_ECOLI Catalyzes the reversible aldol-ketol isomerization between D-ribulose 5-phosphate (Ru5P) and D-arabinose 5-phosphate (A5P). It appears that the physiological function of G-API may be to synthesize the regulatory molecule A5P, which in turn participates in the induction of the gut operon through an unknown mechanism. It is also able of sustaining the biosynthetic pathway of 3-deoxy-D-manno-octulosonate (KDO), a unique 8-carbon sugar component of lipopolysaccharides (LPSs). {ECO 0000269|PubMed 16199563}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0019146 arabinose-5-phosphate isomerase activity; IDA:EcoCyc. # GO_function GO:0030246 carbohydrate binding; IEA:InterPro. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0019294 keto-3-deoxy-D-manno-octulosonic acid biosynthetic process; IMP:UniProtKB. # GO_process GO:0044010 single-species biofilm formation; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # IntAct P17115 2 # InterPro IPR000644 CBS_dom # InterPro IPR001347 SIS # InterPro IPR004800 KdsD/KpsF-type # Organism GUTQ_ECOLI Escherichia coli (strain K12) # PATRIC 32120814 VBIEscCol129921_2799 # PIRSF PIRSF004692 KdsD_KpsF # PROSITE PS51371 CBS; 2 # PROSITE PS51464 SIS # Pfam PF00571 CBS # Pfam PF01380 SIS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GUTQ_ECOLI Arabinose 5-phosphate isomerase GutQ # RefSeq NP_417188 NC_000913.3 # RefSeq WP_001287420 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA69217.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA35745.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=CAA35745.1; Type=Frameshift; Positions=214; Evidence={ECO:0000305}; # SIMILARITY Belongs to the SIS family. GutQ/KpsF subfamily. {ECO 0000305}. # SIMILARITY Contains 1 SIS domain. {ECO:0000255|PROSITE- ProRule PRU00797}. # SIMILARITY Contains 2 CBS domains. {ECO:0000255|PROSITE- ProRule PRU00703}. # SUBUNIT Homotetramer. {ECO:0000269|PubMed 16199563}. # TIGRFAMs TIGR00393 kpsF # eggNOG COG0517 LUCA # eggNOG COG0794 LUCA # eggNOG ENOG4105C2X Bacteria BLAST swissprot:GUTQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GUTQ_ECOLI BioCyc ECOL316407:JW5431-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5431-MONOMER BioCyc EcoCyc:EG10973-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10973-MONOMER BioCyc MetaCyc:EG10973-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10973-MONOMER COG COG0517 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0517 COG COG0794 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0794 DOI 10.1002/pmic.200600599 http://dx.doi.org/10.1002/pmic.200600599 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.187.20.6936-6942.2005 http://dx.doi.org/10.1128/JB.187.20.6936-6942.2005 EC_number EC:5.3.1.13 http://www.genome.jp/dbget-bin/www_bget?EC:5.3.1.13 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EMBL X51361 http://www.ebi.ac.uk/ena/data/view/X51361 ENZYME 5.3.1.13 http://enzyme.expasy.org/EC/5.3.1.13 EchoBASE EB0966 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0966 EcoGene EG10973 http://www.ecogene.org/geneInfo.php?eg_id=EG10973 EnsemblBacteria AAC75750 http://www.ensemblgenomes.org/id/AAC75750 EnsemblBacteria AAC75750 http://www.ensemblgenomes.org/id/AAC75750 EnsemblBacteria BAE76785 http://www.ensemblgenomes.org/id/BAE76785 EnsemblBacteria BAE76785 http://www.ensemblgenomes.org/id/BAE76785 EnsemblBacteria BAE76785 http://www.ensemblgenomes.org/id/BAE76785 EnsemblBacteria b2708 http://www.ensemblgenomes.org/id/b2708 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0019146 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019146 GO_function GO:0030246 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030246 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0019294 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019294 GO_process GO:0044010 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044010 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 947587 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947587 HOGENOM HOG000264729 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000264729&db=HOGENOM6 InParanoid P17115 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P17115 IntAct P17115 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P17115* IntEnz 5.3.1.13 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.3.1.13 InterPro IPR000644 http://www.ebi.ac.uk/interpro/entry/IPR000644 InterPro IPR001347 http://www.ebi.ac.uk/interpro/entry/IPR001347 InterPro IPR004800 http://www.ebi.ac.uk/interpro/entry/IPR004800 KEGG_Gene ecj:JW5431 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5431 KEGG_Gene eco:b2708 http://www.genome.jp/dbget-bin/www_bget?eco:b2708 KEGG_Orthology KO:K02467 http://www.genome.jp/dbget-bin/www_bget?KO:K02467 OMA AVCDEAN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AVCDEAN PROSITE PS51371 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51371 PROSITE PS51464 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51464 PSORT swissprot:GUTQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GUTQ_ECOLI PSORT-B swissprot:GUTQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GUTQ_ECOLI PSORT2 swissprot:GUTQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GUTQ_ECOLI Pfam PF00571 http://pfam.xfam.org/family/PF00571 Pfam PF01380 http://pfam.xfam.org/family/PF01380 Phobius swissprot:GUTQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GUTQ_ECOLI PhylomeDB P17115 http://phylomedb.org/?seqid=P17115 ProteinModelPortal P17115 http://www.proteinmodelportal.org/query/uniprot/P17115 PubMed 16199563 http://www.ncbi.nlm.nih.gov/pubmed/16199563 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17366475 http://www.ncbi.nlm.nih.gov/pubmed/17366475 PubMed 2134185 http://www.ncbi.nlm.nih.gov/pubmed/2134185 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417188 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417188 RefSeq WP_001287420 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001287420 SMR P17115 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P17115 STRING 511145.b2708 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2708&targetmode=cogs STRING COG0517 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0517&targetmode=cogs STRING COG0794 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0794&targetmode=cogs TIGRFAMs TIGR00393 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00393 UniProtKB GUTQ_ECOLI http://www.uniprot.org/uniprot/GUTQ_ECOLI UniProtKB-AC P17115 http://www.uniprot.org/uniprot/P17115 charge swissprot:GUTQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GUTQ_ECOLI eggNOG COG0517 http://eggnogapi.embl.de/nog_data/html/tree/COG0517 eggNOG COG0794 http://eggnogapi.embl.de/nog_data/html/tree/COG0794 eggNOG ENOG4105C2X http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C2X epestfind swissprot:GUTQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GUTQ_ECOLI garnier swissprot:GUTQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GUTQ_ECOLI helixturnhelix swissprot:GUTQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GUTQ_ECOLI hmoment swissprot:GUTQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GUTQ_ECOLI iep swissprot:GUTQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GUTQ_ECOLI inforesidue swissprot:GUTQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GUTQ_ECOLI octanol swissprot:GUTQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GUTQ_ECOLI pepcoil swissprot:GUTQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GUTQ_ECOLI pepdigest swissprot:GUTQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GUTQ_ECOLI pepinfo swissprot:GUTQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GUTQ_ECOLI pepnet swissprot:GUTQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GUTQ_ECOLI pepstats swissprot:GUTQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GUTQ_ECOLI pepwheel swissprot:GUTQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GUTQ_ECOLI pepwindow swissprot:GUTQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GUTQ_ECOLI sigcleave swissprot:GUTQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GUTQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4259176 18 # EcoGene EG11995 yehI # IntAct P33346 8 # InterPro IPR025406 DUF4132 # Organism YEHI_ECOLI Escherichia coli (strain K12) # PATRIC 32119569 VBIEscCol129921_2195 # PIR E64979 E64979 # Pfam PF13569 DUF4132 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEHI_ECOLI Uncharacterized protein YehI # RefSeq NP_416621 NC_000913.3 # RefSeq WP_000356817 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA60478.1; Type=Frameshift; Positions=349, 354; Evidence={ECO 0000305}; # SIMILARITY To E.coli molybdate metabolism regulator (MolR). {ECO 0000305}. # eggNOG ENOG4108KDT Bacteria # eggNOG ENOG4111FHT LUCA BLAST swissprot:YEHI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEHI_ECOLI BioCyc ECOL316407:JW2105-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2105-MONOMER BioCyc EcoCyc:EG11995-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11995-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1936 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1936 EcoGene EG11995 http://www.ecogene.org/geneInfo.php?eg_id=EG11995 EnsemblBacteria AAC75179 http://www.ensemblgenomes.org/id/AAC75179 EnsemblBacteria AAC75179 http://www.ensemblgenomes.org/id/AAC75179 EnsemblBacteria BAE76593 http://www.ensemblgenomes.org/id/BAE76593 EnsemblBacteria BAE76593 http://www.ensemblgenomes.org/id/BAE76593 EnsemblBacteria BAE76593 http://www.ensemblgenomes.org/id/BAE76593 EnsemblBacteria b2118 http://www.ensemblgenomes.org/id/b2118 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946649 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946649 HOGENOM HOG000122164 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122164&db=HOGENOM6 IntAct P33346 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33346* InterPro IPR025406 http://www.ebi.ac.uk/interpro/entry/IPR025406 KEGG_Gene ecj:JW2105 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2105 KEGG_Gene eco:b2118 http://www.genome.jp/dbget-bin/www_bget?eco:b2118 OMA ESSWQRC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ESSWQRC PSORT swissprot:YEHI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEHI_ECOLI PSORT-B swissprot:YEHI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEHI_ECOLI PSORT2 swissprot:YEHI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEHI_ECOLI Pfam PF13569 http://pfam.xfam.org/family/PF13569 Phobius swissprot:YEHI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEHI_ECOLI ProteinModelPortal P33346 http://www.proteinmodelportal.org/query/uniprot/P33346 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416621 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416621 RefSeq WP_000356817 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000356817 SMR P33346 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33346 STRING 511145.b2118 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2118&targetmode=cogs UniProtKB YEHI_ECOLI http://www.uniprot.org/uniprot/YEHI_ECOLI UniProtKB-AC P33346 http://www.uniprot.org/uniprot/P33346 charge swissprot:YEHI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEHI_ECOLI eggNOG ENOG4108KDT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108KDT eggNOG ENOG4111FHT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111FHT epestfind swissprot:YEHI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEHI_ECOLI garnier swissprot:YEHI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEHI_ECOLI helixturnhelix swissprot:YEHI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEHI_ECOLI hmoment swissprot:YEHI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEHI_ECOLI iep swissprot:YEHI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEHI_ECOLI inforesidue swissprot:YEHI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEHI_ECOLI octanol swissprot:YEHI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEHI_ECOLI pepcoil swissprot:YEHI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEHI_ECOLI pepdigest swissprot:YEHI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEHI_ECOLI pepinfo swissprot:YEHI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEHI_ECOLI pepnet swissprot:YEHI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEHI_ECOLI pepstats swissprot:YEHI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEHI_ECOLI pepwheel swissprot:YEHI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEHI_ECOLI pepwindow swissprot:YEHI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEHI_ECOLI sigcleave swissprot:YEHI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEHI_ECOLI ## Database ID URL or Descriptions # BioGrid 4260294 234 # COFACTOR Name=FAD; Xref=ChEBI:CHEBI 57692; Evidence={ECO:0000305}; # EcoGene EG13978 ydiS # FUNCTION YDIS_ECOLI Probably accepts electrons from YdiQ/YdiR and reduces a quinone. # GO_function GO:0016491 oxidoreductase activity; IEA:UniProtKB-KW. # GO_function GO:0071949 FAD binding; IEA:InterPro. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # Gene3D 3.50.50.60 -; 2. # IntAct P77337 5 # InterPro IPR002938 FAD-bd # InterPro IPR023753 FAD/NAD-binding_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00910 Nitrogen metabolism # Organism YDIS_ECOLI Escherichia coli (strain K12) # PATRIC 32118704 VBIEscCol129921_1770 # PIR C64928 C64928 # Pfam PF01494 FAD_binding_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDIS_ECOLI Probable electron transfer flavoprotein-quinone oxidoreductase YdiS # RefSeq NP_416214 NC_000913.3 # RefSeq WP_001278525 NZ_LN832404.1 # SIMILARITY Belongs to the ETF-QO/FixC family. {ECO 0000305}. # SUPFAM SSF51905 SSF51905; 2 # eggNOG COG0644 LUCA # eggNOG ENOG4105DWH Bacteria BLAST swissprot:YDIS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDIS_ECOLI BioCyc ECOL316407:JW1689-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1689-MONOMER BioCyc EcoCyc:G6922-MONOMER http://biocyc.org/getid?id=EcoCyc:G6922-MONOMER COG COG0644 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0644 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.5.5.- http://www.genome.jp/dbget-bin/www_bget?EC:1.5.5.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.5.5.- http://enzyme.expasy.org/EC/1.5.5.- EchoBASE EB3735 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3735 EcoGene EG13978 http://www.ecogene.org/geneInfo.php?eg_id=EG13978 EnsemblBacteria AAC74769 http://www.ensemblgenomes.org/id/AAC74769 EnsemblBacteria AAC74769 http://www.ensemblgenomes.org/id/AAC74769 EnsemblBacteria BAA15468 http://www.ensemblgenomes.org/id/BAA15468 EnsemblBacteria BAA15468 http://www.ensemblgenomes.org/id/BAA15468 EnsemblBacteria BAA15468 http://www.ensemblgenomes.org/id/BAA15468 EnsemblBacteria b1699 http://www.ensemblgenomes.org/id/b1699 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0071949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071949 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 GeneID 946212 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946212 HOGENOM HOG000018936 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000018936&db=HOGENOM6 InParanoid P77337 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77337 IntAct P77337 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77337* IntEnz 1.5.5 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.5.5 InterPro IPR002938 http://www.ebi.ac.uk/interpro/entry/IPR002938 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1689 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1689 KEGG_Gene eco:b1699 http://www.genome.jp/dbget-bin/www_bget?eco:b1699 KEGG_Orthology KO:K00313 http://www.genome.jp/dbget-bin/www_bget?KO:K00313 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 OMA EAPVERW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EAPVERW PSORT swissprot:YDIS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDIS_ECOLI PSORT-B swissprot:YDIS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDIS_ECOLI PSORT2 swissprot:YDIS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDIS_ECOLI Pfam PF01494 http://pfam.xfam.org/family/PF01494 Phobius swissprot:YDIS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDIS_ECOLI PhylomeDB P77337 http://phylomedb.org/?seqid=P77337 ProteinModelPortal P77337 http://www.proteinmodelportal.org/query/uniprot/P77337 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416214 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416214 RefSeq WP_001278525 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001278525 SMR P77337 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77337 STRING 511145.b1699 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1699&targetmode=cogs STRING COG0644 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0644&targetmode=cogs SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 UniProtKB YDIS_ECOLI http://www.uniprot.org/uniprot/YDIS_ECOLI UniProtKB-AC P77337 http://www.uniprot.org/uniprot/P77337 charge swissprot:YDIS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDIS_ECOLI eggNOG COG0644 http://eggnogapi.embl.de/nog_data/html/tree/COG0644 eggNOG ENOG4105DWH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DWH epestfind swissprot:YDIS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDIS_ECOLI garnier swissprot:YDIS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDIS_ECOLI helixturnhelix swissprot:YDIS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDIS_ECOLI hmoment swissprot:YDIS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDIS_ECOLI iep swissprot:YDIS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDIS_ECOLI inforesidue swissprot:YDIS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDIS_ECOLI octanol swissprot:YDIS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDIS_ECOLI pepcoil swissprot:YDIS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDIS_ECOLI pepdigest swissprot:YDIS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDIS_ECOLI pepinfo swissprot:YDIS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDIS_ECOLI pepnet swissprot:YDIS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDIS_ECOLI pepstats swissprot:YDIS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDIS_ECOLI pepwheel swissprot:YDIS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDIS_ECOLI pepwindow swissprot:YDIS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDIS_ECOLI sigcleave swissprot:YDIS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDIS_ECOLI ## Database ID URL or Descriptions # BioGrid 4259782 16 # EcoGene EG13552 yagM # IntAct P71296 5 # InterPro IPR016513 UCP007319 # Organism YAGM_ECOLI Escherichia coli (strain K12) # PATRIC 32115681 VBIEscCol129921_0284 # PIR G64753 G64753 # PIRSF PIRSF007319 UCP007319 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAGM_ECOLI Uncharacterized protein YagM # RefSeq NP_414813 NC_000913.3 # RefSeq WP_000072039 NZ_LN832404.1 # eggNOG ENOG4106GND Bacteria # eggNOG ENOG410Y2QZ LUCA BLAST swissprot:YAGM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAGM_ECOLI BioCyc ECOL316407:JW0273-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0273-MONOMER BioCyc EcoCyc:G6150-MONOMER http://biocyc.org/getid?id=EcoCyc:G6150-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB3322 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3322 EcoGene EG13552 http://www.ecogene.org/geneInfo.php?eg_id=EG13552 EnsemblBacteria AAC73382 http://www.ensemblgenomes.org/id/AAC73382 EnsemblBacteria AAC73382 http://www.ensemblgenomes.org/id/AAC73382 EnsemblBacteria BAE76063 http://www.ensemblgenomes.org/id/BAE76063 EnsemblBacteria BAE76063 http://www.ensemblgenomes.org/id/BAE76063 EnsemblBacteria BAE76063 http://www.ensemblgenomes.org/id/BAE76063 EnsemblBacteria b0279 http://www.ensemblgenomes.org/id/b0279 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 944959 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944959 HOGENOM HOG000054878 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000054878&db=HOGENOM6 IntAct P71296 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P71296* InterPro IPR016513 http://www.ebi.ac.uk/interpro/entry/IPR016513 KEGG_Gene ecj:JW0273 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0273 KEGG_Gene eco:b0279 http://www.genome.jp/dbget-bin/www_bget?eco:b0279 OMA VIYNEYF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VIYNEYF PSORT swissprot:YAGM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAGM_ECOLI PSORT-B swissprot:YAGM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAGM_ECOLI PSORT2 swissprot:YAGM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAGM_ECOLI Phobius swissprot:YAGM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAGM_ECOLI ProteinModelPortal P71296 http://www.proteinmodelportal.org/query/uniprot/P71296 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414813 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414813 RefSeq WP_000072039 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000072039 STRING 511145.b0279 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0279&targetmode=cogs UniProtKB YAGM_ECOLI http://www.uniprot.org/uniprot/YAGM_ECOLI UniProtKB-AC P71296 http://www.uniprot.org/uniprot/P71296 charge swissprot:YAGM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAGM_ECOLI eggNOG ENOG4106GND http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106GND eggNOG ENOG410Y2QZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y2QZ epestfind swissprot:YAGM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAGM_ECOLI garnier swissprot:YAGM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAGM_ECOLI helixturnhelix swissprot:YAGM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAGM_ECOLI hmoment swissprot:YAGM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAGM_ECOLI iep swissprot:YAGM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAGM_ECOLI inforesidue swissprot:YAGM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAGM_ECOLI octanol swissprot:YAGM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAGM_ECOLI pepcoil swissprot:YAGM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAGM_ECOLI pepdigest swissprot:YAGM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAGM_ECOLI pepinfo swissprot:YAGM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAGM_ECOLI pepnet swissprot:YAGM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAGM_ECOLI pepstats swissprot:YAGM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAGM_ECOLI pepwheel swissprot:YAGM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAGM_ECOLI pepwindow swissprot:YAGM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAGM_ECOLI sigcleave swissprot:YAGM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAGM_ECOLI ## Database ID URL or Descriptions # BioGrid 4261824 6 # EcoGene EG13334 yafV # GO_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; IEA:InterPro. # GO_process GO:0006807 nitrogen compound metabolic process; IEA:InterPro. # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_process GO:0008150 biological_process # Gene3D 3.60.110.10 -; 1. # InterPro IPR001110 UPF0012_CS # InterPro IPR003010 C-N_Hydrolase # Organism YAFV_ECOLI Escherichia coli (strain K12) # PATRIC 32115553 VBIEscCol129921_0221 # PIR D64746 D64746 # PROSITE PS01227 UPF0012 # PROSITE PS50263 CN_HYDROLASE # Pfam PF00795 CN_hydrolase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAFV_ECOLI Hydrolase YafV # RefSeq NP_414754 NC_000913.3 # RefSeq WP_001118036 NZ_LN832404.1 # SIMILARITY Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family. {ECO 0000305}. # SIMILARITY Contains 1 CN hydrolase domain. {ECO:0000255|PROSITE- ProRule PRU00054}. # SUPFAM SSF56317 SSF56317 # eggNOG COG0388 LUCA # eggNOG ENOG4105CZ7 Bacteria BLAST swissprot:YAFV_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAFV_ECOLI BioCyc ECOL316407:JW5019-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5019-MONOMER BioCyc EcoCyc:G6103-MONOMER http://biocyc.org/getid?id=EcoCyc:G6103-MONOMER COG COG0388 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0388 DIP DIP-11225N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11225N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.5.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.5.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 ENZYME 3.5.-.- http://enzyme.expasy.org/EC/3.5.-.- EchoBASE EB3118 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3118 EcoGene EG13334 http://www.ecogene.org/geneInfo.php?eg_id=EG13334 EnsemblBacteria AAC73323 http://www.ensemblgenomes.org/id/AAC73323 EnsemblBacteria AAC73323 http://www.ensemblgenomes.org/id/AAC73323 EnsemblBacteria BAA77889 http://www.ensemblgenomes.org/id/BAA77889 EnsemblBacteria BAA77889 http://www.ensemblgenomes.org/id/BAA77889 EnsemblBacteria BAA77889 http://www.ensemblgenomes.org/id/BAA77889 EnsemblBacteria b0219 http://www.ensemblgenomes.org/id/b0219 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GO_process GO:0006807 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006807 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.60.110.10 http://www.cathdb.info/version/latest/superfamily/3.60.110.10 GeneID 946585 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946585 HOGENOM HOG000222700 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000222700&db=HOGENOM6 InParanoid Q47679 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q47679 IntEnz 3.5 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5 InterPro IPR001110 http://www.ebi.ac.uk/interpro/entry/IPR001110 InterPro IPR003010 http://www.ebi.ac.uk/interpro/entry/IPR003010 KEGG_Gene ecj:JW5019 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5019 KEGG_Gene eco:b0219 http://www.genome.jp/dbget-bin/www_bget?eco:b0219 KEGG_Orthology KO:K08590 http://www.genome.jp/dbget-bin/www_bget?KO:K08590 OMA YKAGNER http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YKAGNER PROSITE PS01227 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01227 PROSITE PS50263 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50263 PSORT swissprot:YAFV_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAFV_ECOLI PSORT-B swissprot:YAFV_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAFV_ECOLI PSORT2 swissprot:YAFV_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAFV_ECOLI Pfam PF00795 http://pfam.xfam.org/family/PF00795 Phobius swissprot:YAFV_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAFV_ECOLI PhylomeDB Q47679 http://phylomedb.org/?seqid=Q47679 ProteinModelPortal Q47679 http://www.proteinmodelportal.org/query/uniprot/Q47679 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414754 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414754 RefSeq WP_001118036 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001118036 SMR Q47679 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q47679 STRING 511145.b0219 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0219&targetmode=cogs STRING COG0388 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0388&targetmode=cogs SUPFAM SSF56317 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56317 UniProtKB YAFV_ECOLI http://www.uniprot.org/uniprot/YAFV_ECOLI UniProtKB-AC Q47679 http://www.uniprot.org/uniprot/Q47679 charge swissprot:YAFV_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAFV_ECOLI eggNOG COG0388 http://eggnogapi.embl.de/nog_data/html/tree/COG0388 eggNOG ENOG4105CZ7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CZ7 epestfind swissprot:YAFV_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAFV_ECOLI garnier swissprot:YAFV_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAFV_ECOLI helixturnhelix swissprot:YAFV_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAFV_ECOLI hmoment swissprot:YAFV_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAFV_ECOLI iep swissprot:YAFV_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAFV_ECOLI inforesidue swissprot:YAFV_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAFV_ECOLI octanol swissprot:YAFV_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAFV_ECOLI pepcoil swissprot:YAFV_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAFV_ECOLI pepdigest swissprot:YAFV_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAFV_ECOLI pepinfo swissprot:YAFV_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAFV_ECOLI pepnet swissprot:YAFV_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAFV_ECOLI pepstats swissprot:YAFV_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAFV_ECOLI pepwheel swissprot:YAFV_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAFV_ECOLI pepwindow swissprot:YAFV_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAFV_ECOLI sigcleave swissprot:YAFV_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAFV_ECOLI ## Database ID URL or Descriptions # BioGrid 4262862 15 # EcoGene EG14244 ycgX # Gene3D 3.30.1810.10 -; 1. # IntAct P75988 3 # InterPro IPR009833 DUF1398 # Organism YCGX_ECOLI Escherichia coli (strain K12) # PATRIC 32117559 VBIEscCol129921_1202 # PIR F64861 F64861 # Pfam PF07166 DUF1398 # ProDom PD021249 DUF1398 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCGX_ECOLI Uncharacterized protein YcgX # RefSeq NP_415679 NC_000913.3 # RefSeq WP_000373101 NZ_LN832404.1 # SIMILARITY To E.coli YbcV and YdfO. {ECO 0000305}. # SUPFAM SSF160419 SSF160419 # eggNOG COG5562 LUCA # eggNOG ENOG41064WM Bacteria BLAST swissprot:YCGX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCGX_ECOLI BioCyc ECOL316407:JW1148-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1148-MONOMER BioCyc EcoCyc:G6601-MONOMER http://biocyc.org/getid?id=EcoCyc:G6601-MONOMER DIP DIP-11564N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11564N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3994 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3994 EcoGene EG14244 http://www.ecogene.org/geneInfo.php?eg_id=EG14244 EnsemblBacteria AAC74245 http://www.ensemblgenomes.org/id/AAC74245 EnsemblBacteria AAC74245 http://www.ensemblgenomes.org/id/AAC74245 EnsemblBacteria BAE76384 http://www.ensemblgenomes.org/id/BAE76384 EnsemblBacteria BAE76384 http://www.ensemblgenomes.org/id/BAE76384 EnsemblBacteria BAE76384 http://www.ensemblgenomes.org/id/BAE76384 EnsemblBacteria b1161 http://www.ensemblgenomes.org/id/b1161 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.30.1810.10 http://www.cathdb.info/version/latest/superfamily/3.30.1810.10 GeneID 945733 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945733 HOGENOM HOG000119635 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000119635&db=HOGENOM6 IntAct P75988 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75988* InterPro IPR009833 http://www.ebi.ac.uk/interpro/entry/IPR009833 KEGG_Gene ecj:JW1148 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1148 KEGG_Gene eco:b1161 http://www.genome.jp/dbget-bin/www_bget?eco:b1161 OMA WIVELNK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WIVELNK PSORT swissprot:YCGX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCGX_ECOLI PSORT-B swissprot:YCGX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCGX_ECOLI PSORT2 swissprot:YCGX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCGX_ECOLI Pfam PF07166 http://pfam.xfam.org/family/PF07166 Phobius swissprot:YCGX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCGX_ECOLI PhylomeDB P75988 http://phylomedb.org/?seqid=P75988 ProteinModelPortal P75988 http://www.proteinmodelportal.org/query/uniprot/P75988 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415679 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415679 RefSeq WP_000373101 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000373101 SMR P75988 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75988 STRING 511145.b1161 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1161&targetmode=cogs SUPFAM SSF160419 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF160419 UniProtKB YCGX_ECOLI http://www.uniprot.org/uniprot/YCGX_ECOLI UniProtKB-AC P75988 http://www.uniprot.org/uniprot/P75988 charge swissprot:YCGX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCGX_ECOLI eggNOG COG5562 http://eggnogapi.embl.de/nog_data/html/tree/COG5562 eggNOG ENOG41064WM http://eggnogapi.embl.de/nog_data/html/tree/ENOG41064WM epestfind swissprot:YCGX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCGX_ECOLI garnier swissprot:YCGX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCGX_ECOLI helixturnhelix swissprot:YCGX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCGX_ECOLI hmoment swissprot:YCGX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCGX_ECOLI iep swissprot:YCGX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCGX_ECOLI inforesidue swissprot:YCGX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCGX_ECOLI octanol swissprot:YCGX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCGX_ECOLI pepcoil swissprot:YCGX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCGX_ECOLI pepdigest swissprot:YCGX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCGX_ECOLI pepinfo swissprot:YCGX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCGX_ECOLI pepnet swissprot:YCGX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCGX_ECOLI pepstats swissprot:YCGX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCGX_ECOLI pepwheel swissprot:YCGX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCGX_ECOLI pepwindow swissprot:YCGX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCGX_ECOLI sigcleave swissprot:YCGX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCGX_ECOLI ## Database ID URL or Descriptions # AltName PFLA_ECOLI Formate-C-acetyltransferase-activating enzyme 1 # AltName PFLA_ECOLI PFL-activating enzyme 1 # BRENDA 1.97.1 2026 # CATALYTIC ACTIVITY PFLA_ECOLI S-adenosyl-L-methionine + dihydroflavodoxin + [formate C-acetyltransferase]-glycine = 5'-deoxyadenosine + L- methionine + flavodoxin semiquinone + [formate C- acetyltransferase]-glycin-2-yl radical. # COFACTOR PFLA_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000269|PubMed 18852451}; Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. {ECO 0000269|PubMed 18852451}; # EcoGene EG10028 pflA # FUNCTION PFLA_ECOLI Activation of pyruvate formate-lyase 1 under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0016491 oxidoreductase activity; IDA:EcoliWiki. # GO_function GO:0043365 [formate-C-acetyltransferase]-activating enzyme activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IDA:EcoCyc. # GO_process GO:0006006 glucose metabolic process; IEA:UniProtKB-KW. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0018307 enzyme active site formation; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0044281 small molecule metabolic process # INTERACTION PFLA_ECOLI P64455 ydcY; NbExp=4; IntAct=EBI-1114060, EBI-9129853; # IntAct P0A9N4 19 # InterPro IPR001989 Radical_activat_CS # InterPro IPR007197 rSAM # InterPro IPR012838 PFL_activating # KEGG_Brite ko01000 Enzymes # Organism PFLA_ECOLI Escherichia coli (strain K12) # PATRIC 32117017 VBIEscCol129921_0933 # PDB 3C8F X-ray; 2.25 A; A=2-246 # PDB 3CB8 X-ray; 2.77 A; A=2-246 # PIR S01789 S01789 # PROSITE PS01087 RADICAL_ACTIVATING # Pfam PF04055 Radical_SAM # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PFLA_ECOLI Pyruvate formate-lyase 1-activating enzyme # RefSeq NP_415422 NC_000913.3 # RefSeq WP_000111043 NZ_LN832404.1 # SIMILARITY Belongs to the organic radical-activating enzymes family. {ECO 0000305}. # SUBCELLULAR LOCATION PFLA_ECOLI Cytoplasm. # SUBUNIT Monomer. {ECO:0000269|PubMed 18852451}. # TIGRFAMs TIGR02493 PFLA # eggNOG COG1180 LUCA # eggNOG ENOG4105F1A Bacteria BLAST swissprot:PFLA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PFLA_ECOLI BioCyc ECOL316407:JW0885-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0885-MONOMER BioCyc EcoCyc:PFLACTENZ-MONOMER http://biocyc.org/getid?id=EcoCyc:PFLACTENZ-MONOMER COG COG1180 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1180 DIP DIP-35915N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35915N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0806640105 http://dx.doi.org/10.1073/pnas.0806640105 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1432-1033.1988.tb14356.x http://dx.doi.org/10.1111/j.1432-1033.1988.tb14356.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.97.1.4 http://www.genome.jp/dbget-bin/www_bget?EC:1.97.1.4 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X08035 http://www.ebi.ac.uk/ena/data/view/X08035 ENZYME 1.97.1.4 http://enzyme.expasy.org/EC/1.97.1.4 EchoBASE EB0027 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0027 EcoGene EG10028 http://www.ecogene.org/geneInfo.php?eg_id=EG10028 EnsemblBacteria AAC73988 http://www.ensemblgenomes.org/id/AAC73988 EnsemblBacteria AAC73988 http://www.ensemblgenomes.org/id/AAC73988 EnsemblBacteria BAA35637 http://www.ensemblgenomes.org/id/BAA35637 EnsemblBacteria BAA35637 http://www.ensemblgenomes.org/id/BAA35637 EnsemblBacteria BAA35637 http://www.ensemblgenomes.org/id/BAA35637 EnsemblBacteria b0902 http://www.ensemblgenomes.org/id/b0902 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0043365 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043365 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0006006 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006006 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0018307 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018307 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 945517 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945517 HOGENOM HOG000011458 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000011458&db=HOGENOM6 InParanoid P0A9N4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9N4 IntAct P0A9N4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9N4* IntEnz 1.97.1.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.97.1.4 InterPro IPR001989 http://www.ebi.ac.uk/interpro/entry/IPR001989 InterPro IPR007197 http://www.ebi.ac.uk/interpro/entry/IPR007197 InterPro IPR012838 http://www.ebi.ac.uk/interpro/entry/IPR012838 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0885 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0885 KEGG_Gene eco:b0902 http://www.genome.jp/dbget-bin/www_bget?eco:b0902 KEGG_Orthology KO:K04069 http://www.genome.jp/dbget-bin/www_bget?KO:K04069 OMA YCHNPDC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YCHNPDC PDB 3C8F http://www.ebi.ac.uk/pdbe-srv/view/entry/3C8F PDB 3CB8 http://www.ebi.ac.uk/pdbe-srv/view/entry/3CB8 PDBsum 3C8F http://www.ebi.ac.uk/pdbsum/3C8F PDBsum 3CB8 http://www.ebi.ac.uk/pdbsum/3CB8 PROSITE PS01087 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01087 PSORT swissprot:PFLA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PFLA_ECOLI PSORT-B swissprot:PFLA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PFLA_ECOLI PSORT2 swissprot:PFLA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PFLA_ECOLI Pfam PF04055 http://pfam.xfam.org/family/PF04055 Phobius swissprot:PFLA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PFLA_ECOLI PhylomeDB P0A9N4 http://phylomedb.org/?seqid=P0A9N4 ProteinModelPortal P0A9N4 http://www.proteinmodelportal.org/query/uniprot/P0A9N4 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18852451 http://www.ncbi.nlm.nih.gov/pubmed/18852451 PubMed 3053170 http://www.ncbi.nlm.nih.gov/pubmed/3053170 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415422 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415422 RefSeq WP_000111043 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000111043 SMR P0A9N4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9N4 STRING 511145.b0902 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0902&targetmode=cogs STRING COG1180 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1180&targetmode=cogs TIGRFAMs TIGR02493 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02493 UniProtKB PFLA_ECOLI http://www.uniprot.org/uniprot/PFLA_ECOLI UniProtKB-AC P0A9N4 http://www.uniprot.org/uniprot/P0A9N4 charge swissprot:PFLA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PFLA_ECOLI eggNOG COG1180 http://eggnogapi.embl.de/nog_data/html/tree/COG1180 eggNOG ENOG4105F1A http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F1A epestfind swissprot:PFLA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PFLA_ECOLI garnier swissprot:PFLA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PFLA_ECOLI helixturnhelix swissprot:PFLA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PFLA_ECOLI hmoment swissprot:PFLA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PFLA_ECOLI iep swissprot:PFLA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PFLA_ECOLI inforesidue swissprot:PFLA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PFLA_ECOLI octanol swissprot:PFLA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PFLA_ECOLI pepcoil swissprot:PFLA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PFLA_ECOLI pepdigest swissprot:PFLA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PFLA_ECOLI pepinfo swissprot:PFLA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PFLA_ECOLI pepnet swissprot:PFLA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PFLA_ECOLI pepstats swissprot:PFLA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PFLA_ECOLI pepwheel swissprot:PFLA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PFLA_ECOLI pepwindow swissprot:PFLA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PFLA_ECOLI sigcleave swissprot:PFLA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PFLA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261556 5 # EcoGene EG12270 yiaC # GO_component GO:0031248 protein acetyltransferase complex; IBA:GO_Central. # GO_function GO:0004596 peptide alpha-N-acetyltransferase activity; IBA:GO_Central. # GO_process GO:0006474 N-terminal protein amino acid acetylation; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0006464 cellular protein modification process # Gene3D 3.40.630.30 -; 1. # IntAct P37664 3 # InterPro IPR000182 GNAT_dom # InterPro IPR016181 Acyl_CoA_acyltransferase # KEGG_Brite ko01000 Enzymes # Organism YIAC_ECOLI Escherichia coli (strain K12) # PATRIC 32122572 VBIEscCol129921_3663 # PIR S47771 S47771 # PROSITE PS51186 GNAT # Pfam PF13673 Acetyltransf_10 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIAC_ECOLI Uncharacterized N-acetyltransferase YiaC # RefSeq NP_418006 NC_000913.3 # RefSeq WP_000617473 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=M34827; Type=Frameshift; Positions=42; Evidence={ECO 0000305}; # SIMILARITY Belongs to the acetyltransferase family. {ECO 0000305}. # SIMILARITY Contains 1 N-acetyltransferase domain. {ECO:0000255|PROSITE-ProRule PRU00532}. # SUPFAM SSF55729 SSF55729 # eggNOG COG0454 LUCA # eggNOG ENOG4105HNP Bacteria BLAST swissprot:YIAC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIAC_ECOLI BioCyc ECOL316407:JW3519-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3519-MONOMER BioCyc EcoCyc:EG12270-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12270-MONOMER COG COG0454 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0454 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M34827 http://www.ebi.ac.uk/ena/data/view/M34827 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.3.1.- http://enzyme.expasy.org/EC/2.3.1.- EchoBASE EB2179 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2179 EcoGene EG12270 http://www.ecogene.org/geneInfo.php?eg_id=EG12270 EnsemblBacteria AAC76574 http://www.ensemblgenomes.org/id/AAC76574 EnsemblBacteria AAC76574 http://www.ensemblgenomes.org/id/AAC76574 EnsemblBacteria BAE77745 http://www.ensemblgenomes.org/id/BAE77745 EnsemblBacteria BAE77745 http://www.ensemblgenomes.org/id/BAE77745 EnsemblBacteria BAE77745 http://www.ensemblgenomes.org/id/BAE77745 EnsemblBacteria b3550 http://www.ensemblgenomes.org/id/b3550 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0031248 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031248 GO_function GO:0004596 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004596 GO_process GO:0006474 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006474 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 Gene3D 3.40.630.30 http://www.cathdb.info/version/latest/superfamily/3.40.630.30 GeneID 946460 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946460 HOGENOM HOG000078517 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000078517&db=HOGENOM6 InParanoid P37664 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37664 IntAct P37664 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37664* IntEnz 2.3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1 InterPro IPR000182 http://www.ebi.ac.uk/interpro/entry/IPR000182 InterPro IPR016181 http://www.ebi.ac.uk/interpro/entry/IPR016181 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3519 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3519 KEGG_Gene eco:b3550 http://www.genome.jp/dbget-bin/www_bget?eco:b3550 KEGG_Orthology KO:K03826 http://www.genome.jp/dbget-bin/www_bget?KO:K03826 OMA RAVNFYH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RAVNFYH PROSITE PS51186 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51186 PSORT swissprot:YIAC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIAC_ECOLI PSORT-B swissprot:YIAC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIAC_ECOLI PSORT2 swissprot:YIAC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIAC_ECOLI Pfam PF13673 http://pfam.xfam.org/family/PF13673 Phobius swissprot:YIAC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIAC_ECOLI PhylomeDB P37664 http://phylomedb.org/?seqid=P37664 ProteinModelPortal P37664 http://www.proteinmodelportal.org/query/uniprot/P37664 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2180922 http://www.ncbi.nlm.nih.gov/pubmed/2180922 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418006 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418006 RefSeq WP_000617473 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000617473 SMR P37664 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37664 STRING 511145.b3550 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3550&targetmode=cogs STRING COG0454 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0454&targetmode=cogs SUPFAM SSF55729 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55729 UniProtKB YIAC_ECOLI http://www.uniprot.org/uniprot/YIAC_ECOLI UniProtKB-AC P37664 http://www.uniprot.org/uniprot/P37664 charge swissprot:YIAC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIAC_ECOLI eggNOG COG0454 http://eggnogapi.embl.de/nog_data/html/tree/COG0454 eggNOG ENOG4105HNP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105HNP epestfind swissprot:YIAC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIAC_ECOLI garnier swissprot:YIAC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIAC_ECOLI helixturnhelix swissprot:YIAC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIAC_ECOLI hmoment swissprot:YIAC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIAC_ECOLI iep swissprot:YIAC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIAC_ECOLI inforesidue swissprot:YIAC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIAC_ECOLI octanol swissprot:YIAC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIAC_ECOLI pepcoil swissprot:YIAC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIAC_ECOLI pepdigest swissprot:YIAC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIAC_ECOLI pepinfo swissprot:YIAC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIAC_ECOLI pepnet swissprot:YIAC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIAC_ECOLI pepstats swissprot:YIAC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIAC_ECOLI pepwheel swissprot:YIAC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIAC_ECOLI pepwindow swissprot:YIAC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIAC_ECOLI sigcleave swissprot:YIAC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIAC_ECOLI ## Database ID URL or Descriptions # AltName Enzyme I-Ani {ECO:0000303|PubMed 7773398} # AltName Fructose-like phosphotransferase enzyme IIA component {ECO:0000303|PubMed 7773398} # AltName Phosphotransferase system enzyme I {ECO:0000303|PubMed 7773398} # AltName Phosphotransferase system enzyme I {ECO:0000303|PubMed 7773398} # AltName Triphosphoryl transfer protein 2 {ECO:0000250|UniProtKB P77439} # BioGrid 4262062 11 # CATALYTIC ACTIVITY Phosphoenolpyruvate + protein L-histidine = pyruvate + protein N(pi)-phospho-L-histidine. {ECO:0000250|UniProtKB P08839}. # CATALYTIC ACTIVITY [Protein]-N(pi)-phospho-L-histidine + D- fructose(Side 1) = [protein]-L-histidine + D-fructose 1- phosphate(Side 2). {ECO:0000250|UniProtKB P20966}. # CDD cd00367 PTS-HPr_like # COFACTOR PTFX2_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250|UniProtKB P08839}; # DOMAIN PTFX2_ECOLI In contrast to classical PTS systems, the fructose-like PTS has no requirement for HPr and Enzyme I; PtsA combines a IIA domain with an Enzyme I and a HPr domains. {ECO 0000305}. # DOMAIN PTFX2_ECOLI The PTS EIIA type-2 domain is phosphorylated by phospho- HPr on a histidyl residue. Then, it transfers the phosphoryl group to the PTS EIIB type-2 domain. {ECO 0000255|PROSITE- ProRule PRU00417}. # EcoGene EG11906 ptsA # FUNCTION PTFX2_ECOLI Multifunctional protein that includes general (non sugar-specific) and sugar-specific components of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FrwABC PTS system is involved in fructose transport. {ECO 0000305|PubMed 7773398}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0005215 transporter activity; IEA:InterPro. # GO_function GO:0008965 phosphoenolpyruvate-protein phosphotransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016301 kinase activity; IEA:UniProtKB-KW. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # Gene3D 1.10.274.10 -; 1. # Gene3D 3.20.20.60 -; 1. # Gene3D 3.30.1340.10 -; 1. # Gene3D 3.40.930.10 -; 1. # Gene3D 3.50.30.10 -; 1. # InterPro IPR000032 HPr-like # InterPro IPR000121 PEP_util_C # InterPro IPR001020 PTS_HPr_His_P_site # InterPro IPR002178 PTS_EIIA_type-2_dom # InterPro IPR006318 PTS_EI-like # InterPro IPR008279 PEP-util_enz_mobile_dom # InterPro IPR008731 PTS_EIN # InterPro IPR015813 Pyrv/PenolPyrv_Kinase-like_dom # InterPro IPR016152 PTrfase/Anion_transptr # InterPro IPR018274 PEP_util_AS # InterPro IPR023151 PEP_util_CS # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00306 PTS system, fructose-specific II-like component # KEGG_Brite ko02000 Transporters # Organism PTFX2_ECOLI Escherichia coli (strain K12) # PATRIC 32123417 VBIEscCol129921_4069 # PROSITE PS00369 PTS_HPR_HIS # PROSITE PS00370 PEP_ENZYMES_PHOS_SITE # PROSITE PS00742 PEP_ENZYMES_2 # PROSITE PS51094 PTS_EIIA_TYPE_2 # PROSITE PS51350 PTS_HPR_DOM # Pfam PF00359 PTS_EIIA_2 # Pfam PF00381 PTS-HPr # Pfam PF00391 PEP-utilizers # Pfam PF02896 PEP-utilizers_C # Pfam PF05524 PEP-utilisers_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Multiphosphoryl transfer protein 2 {ECO:0000305|PubMed 7773398} # RecName PTS system fructose-like EIIA component {ECO:0000303|PubMed 7773398} # RecName Phosphocarrier protein HPr {ECO:0000250|UniProtKB P77439} # RecName Phosphoenolpyruvate-protein phosphotransferase {ECO:0000303|PubMed 7773398} # RefSeq WP_001174077 NZ_LN832404.1 # RefSeq YP_026278 NC_000913.3 # SEQUENCE CAUTION Sequence=AAC43053.1; Type=Frameshift; Positions=45; Evidence={ECO 0000305}; # SIMILARITY Belongs to the PEP-utilizing enzyme family. {ECO 0000305}. # SIMILARITY Contains 1 HPr domain. {ECO:0000255|PROSITE- ProRule PRU00681}. # SIMILARITY Contains 1 PTS EIIA type-2 domain. {ECO:0000255|PROSITE-ProRule PRU00417}. # SUBCELLULAR LOCATION PTFX2_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF47831 SSF47831 # SUPFAM SSF51621 SSF51621 # SUPFAM SSF52009 SSF52009 # SUPFAM SSF55594 SSF55594 # SUPFAM SSF55804 SSF55804 # TCDB 4.A.2.1.10 the pts fructose-mannitol (fru) family # TIGRFAMs TIGR01417 PTS_I_fam # eggNOG COG1080 LUCA # eggNOG COG1762 LUCA # eggNOG COG1925 LUCA # eggNOG ENOG4105BZ3 Bacteria BLAST swissprot:PTFX2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTFX2_ECOLI BioCyc ECOL316407:JW5555-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5555-MONOMER BioCyc EcoCyc:EG11906-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11906-MONOMER COG COG1762 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1762 DIP DIP-10601N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10601N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1099/13500872-141-4-961 http://dx.doi.org/10.1099/13500872-141-4-961 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.202 {ECO:0000250|UniProtKB:P20966} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.202 {ECO:0000250|UniProtKB:P20966} EC_number EC:2.7.3.9 {ECO:0000250|UniProtKB:P08839} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.3.9 {ECO:0000250|UniProtKB:P08839} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.202 {ECO:0000250|UniProtKB:P20966} http://enzyme.expasy.org/EC/2.7.1.202 {ECO:0000250|UniProtKB:P20966} ENZYME 2.7.3.9 {ECO:0000250|UniProtKB:P08839} http://enzyme.expasy.org/EC/2.7.3.9 {ECO:0000250|UniProtKB:P08839} EchoBASE EB1851 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1851 EcoGene EG11906 http://www.ecogene.org/geneInfo.php?eg_id=EG11906 EnsemblBacteria AAT48236 http://www.ensemblgenomes.org/id/AAT48236 EnsemblBacteria AAT48236 http://www.ensemblgenomes.org/id/AAT48236 EnsemblBacteria BAE77363 http://www.ensemblgenomes.org/id/BAE77363 EnsemblBacteria BAE77363 http://www.ensemblgenomes.org/id/BAE77363 EnsemblBacteria BAE77363 http://www.ensemblgenomes.org/id/BAE77363 EnsemblBacteria b3947 http://www.ensemblgenomes.org/id/b3947 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_function GO:0008965 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008965 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 1.10.274.10 http://www.cathdb.info/version/latest/superfamily/1.10.274.10 Gene3D 3.20.20.60 http://www.cathdb.info/version/latest/superfamily/3.20.20.60 Gene3D 3.30.1340.10 http://www.cathdb.info/version/latest/superfamily/3.30.1340.10 Gene3D 3.40.930.10 http://www.cathdb.info/version/latest/superfamily/3.40.930.10 Gene3D 3.50.30.10 http://www.cathdb.info/version/latest/superfamily/3.50.30.10 GeneID 948437 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948437 HOGENOM HOG000122933 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122933&db=HOGENOM6 InParanoid P32670 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32670 IntEnz 2.7.1.202 {ECO:0000250|UniProtKB:P20966} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.202 {ECO:0000250|UniProtKB:P20966} IntEnz 2.7.3.9 {ECO:0000250|UniProtKB:P08839} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.3.9 {ECO:0000250|UniProtKB:P08839} InterPro IPR000032 http://www.ebi.ac.uk/interpro/entry/IPR000032 InterPro IPR000121 http://www.ebi.ac.uk/interpro/entry/IPR000121 InterPro IPR001020 http://www.ebi.ac.uk/interpro/entry/IPR001020 InterPro IPR002178 http://www.ebi.ac.uk/interpro/entry/IPR002178 InterPro IPR006318 http://www.ebi.ac.uk/interpro/entry/IPR006318 InterPro IPR008279 http://www.ebi.ac.uk/interpro/entry/IPR008279 InterPro IPR008731 http://www.ebi.ac.uk/interpro/entry/IPR008731 InterPro IPR015813 http://www.ebi.ac.uk/interpro/entry/IPR015813 InterPro IPR016152 http://www.ebi.ac.uk/interpro/entry/IPR016152 InterPro IPR018274 http://www.ebi.ac.uk/interpro/entry/IPR018274 InterPro IPR023151 http://www.ebi.ac.uk/interpro/entry/IPR023151 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5555 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5555 KEGG_Gene eco:b3947 http://www.genome.jp/dbget-bin/www_bget?eco:b3947 KEGG_Orthology KO:K11201 http://www.genome.jp/dbget-bin/www_bget?KO:K11201 OMA HIYGEQR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HIYGEQR PROSITE PS00369 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00369 PROSITE PS00370 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00370 PROSITE PS00742 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00742 PROSITE PS51094 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51094 PROSITE PS51350 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51350 PSORT swissprot:PTFX2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTFX2_ECOLI PSORT-B swissprot:PTFX2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTFX2_ECOLI PSORT2 swissprot:PTFX2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTFX2_ECOLI Pfam PF00359 http://pfam.xfam.org/family/PF00359 Pfam PF00381 http://pfam.xfam.org/family/PF00381 Pfam PF00391 http://pfam.xfam.org/family/PF00391 Pfam PF02896 http://pfam.xfam.org/family/PF02896 Pfam PF05524 http://pfam.xfam.org/family/PF05524 Phobius swissprot:PTFX2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTFX2_ECOLI PhylomeDB P32670 http://phylomedb.org/?seqid=P32670 ProteinModelPortal P32670 http://www.proteinmodelportal.org/query/uniprot/P32670 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7773398 http://www.ncbi.nlm.nih.gov/pubmed/7773398 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001174077 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001174077 RefSeq YP_026278 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026278 SMR P32670 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32670 STRING 511145.b3947 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3947&targetmode=cogs STRING COG1762 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1762&targetmode=cogs SUPFAM SSF47831 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47831 SUPFAM SSF51621 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51621 SUPFAM SSF52009 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52009 SUPFAM SSF55594 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55594 SUPFAM SSF55804 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55804 TCDB 4.A.2.1.10 http://www.tcdb.org/search/result.php?tc=4.A.2.1.10 TIGRFAMs TIGR01417 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01417 UniProtKB PTFX2_ECOLI http://www.uniprot.org/uniprot/PTFX2_ECOLI UniProtKB-AC P32670 http://www.uniprot.org/uniprot/P32670 charge swissprot:PTFX2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTFX2_ECOLI eggNOG COG1080 http://eggnogapi.embl.de/nog_data/html/tree/COG1080 eggNOG COG1762 http://eggnogapi.embl.de/nog_data/html/tree/COG1762 eggNOG COG1925 http://eggnogapi.embl.de/nog_data/html/tree/COG1925 eggNOG ENOG4105BZ3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZ3 epestfind swissprot:PTFX2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTFX2_ECOLI garnier swissprot:PTFX2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTFX2_ECOLI helixturnhelix swissprot:PTFX2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTFX2_ECOLI hmoment swissprot:PTFX2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTFX2_ECOLI iep swissprot:PTFX2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTFX2_ECOLI inforesidue swissprot:PTFX2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTFX2_ECOLI octanol swissprot:PTFX2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTFX2_ECOLI pepcoil swissprot:PTFX2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTFX2_ECOLI pepdigest swissprot:PTFX2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTFX2_ECOLI pepinfo swissprot:PTFX2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTFX2_ECOLI pepnet swissprot:PTFX2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTFX2_ECOLI pepstats swissprot:PTFX2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTFX2_ECOLI pepwheel swissprot:PTFX2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTFX2_ECOLI pepwindow swissprot:PTFX2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTFX2_ECOLI sigcleave swissprot:PTFX2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTFX2_ECOLI ## Database ID URL or Descriptions # InterPro IPR004291 Transposase_25 # Organism YUAH_ECOLI Escherichia coli (strain K12) # Pfam PF03050 DDE_Tnp_IS66 # RecName YUAH_ECOLI Uncharacterized protein YuaH # RefSeq NP_061398 NC_002483.1 # RefSeq WP_001351566 NC_002483.1 BLAST swissprot:YUAH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YUAH_ECOLI EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1263520 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263520 InterPro IPR004291 http://www.ebi.ac.uk/interpro/entry/IPR004291 OMA CAPVNAR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CAPVNAR PSORT swissprot:YUAH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YUAH_ECOLI PSORT-B swissprot:YUAH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YUAH_ECOLI PSORT2 swissprot:YUAH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YUAH_ECOLI Pfam PF03050 http://pfam.xfam.org/family/PF03050 Phobius swissprot:YUAH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YUAH_ECOLI PhylomeDB Q9JMT1 http://phylomedb.org/?seqid=Q9JMT1 ProteinModelPortal Q9JMT1 http://www.proteinmodelportal.org/query/uniprot/Q9JMT1 RefSeq NP_061398 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061398 RefSeq WP_001351566 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001351566 UniProtKB YUAH_ECOLI http://www.uniprot.org/uniprot/YUAH_ECOLI UniProtKB-AC Q9JMT1 http://www.uniprot.org/uniprot/Q9JMT1 charge swissprot:YUAH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YUAH_ECOLI epestfind swissprot:YUAH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YUAH_ECOLI garnier swissprot:YUAH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YUAH_ECOLI helixturnhelix swissprot:YUAH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YUAH_ECOLI hmoment swissprot:YUAH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YUAH_ECOLI iep swissprot:YUAH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YUAH_ECOLI inforesidue swissprot:YUAH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YUAH_ECOLI octanol swissprot:YUAH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YUAH_ECOLI pepcoil swissprot:YUAH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YUAH_ECOLI pepdigest swissprot:YUAH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YUAH_ECOLI pepinfo swissprot:YUAH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YUAH_ECOLI pepnet swissprot:YUAH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YUAH_ECOLI pepstats swissprot:YUAH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YUAH_ECOLI pepwheel swissprot:YUAH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YUAH_ECOLI pepwindow swissprot:YUAH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YUAH_ECOLI sigcleave swissprot:YUAH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YUAH_ECOLI ## Database ID URL or Descriptions # BioGrid 4263081 6 # EcoGene EG12462 adiC # FUNCTION ADIC_ECOLI Major component of the acid-resistance (AR) system allowing enteric pathogens to survive the acidic environment in the stomach (By similarity). Exchanges extracellular arginine for its intracellular decarboxylation product agmatine (Agm) thereby expelling intracellular protons. {ECO 0000250, ECO 0000269|PubMed 12867448, ECO 0000269|PubMed 14594828}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; ISM:EcoCyc. # GO_function GO:0015179 L-amino acid transmembrane transporter activity; IBA:GO_Central. # GO_function GO:0015181 arginine transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0015297 antiporter activity; IDA:EcoCyc. # GO_process GO:0003333 amino acid transmembrane transport; IDA:EcoCyc. # GO_process GO:0051454 intracellular pH elevation; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0042592 homeostatic process # GOslim_process GO:0055085 transmembrane transport # INDUCTION By acidic conditions. {ECO:0000269|PubMed 12867448}. # InterPro IPR002293 AA/rel_permease1 # KEGG_Brite ko02000 Transporters # Organism ADIC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11785 PTHR11785 # PATRIC 32123795 VBIEscCol129921_4246 # PDB 3OB6 X-ray; 3.00 A; A/B=1-445 # PDB 5J4I X-ray; 2.21 A; A/B=1-445 # PDB 5J4N X-ray; 2.59 A; A/B=1-445 # PIR B65221 B65221 # PIR S56343 S56343 # PIRSF PIRSF006060 AA_transporter # Pfam PF13520 AA_permease_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ADIC_ECOLI Arginine/agmatine antiporter # RefSeq NP_418539 NC_000913.3 # RefSeq WP_000093154 NZ_LN832404.1 # SIMILARITY Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family. {ECO 0000305}. # SUBCELLULAR LOCATION ADIC_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.3.2 the amino acid-polyamine-organocation (apc) family # eggNOG COG0531 LUCA # eggNOG ENOG4105D5Q Bacteria BLAST swissprot:ADIC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ADIC_ECOLI BioCyc ECOL316407:JW4076-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4076-MONOMER BioCyc EcoCyc:YJDE-MONOMER http://biocyc.org/getid?id=EcoCyc:YJDE-MONOMER BioCyc MetaCyc:YJDE-MONOMER http://biocyc.org/getid?id=MetaCyc:YJDE-MONOMER COG COG0531 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0531 DIP DIP-59619N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-59619N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.185.15.4402-4409.2003 http://dx.doi.org/10.1128/JB.185.15.4402-4409.2003 DOI 10.1128/JB.185.22.6556-6561.2003 http://dx.doi.org/10.1128/JB.185.22.6556-6561.2003 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2355 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2355 EcoGene EG12462 http://www.ecogene.org/geneInfo.php?eg_id=EG12462 EnsemblBacteria AAC77076 http://www.ensemblgenomes.org/id/AAC77076 EnsemblBacteria AAC77076 http://www.ensemblgenomes.org/id/AAC77076 EnsemblBacteria BAE78117 http://www.ensemblgenomes.org/id/BAE78117 EnsemblBacteria BAE78117 http://www.ensemblgenomes.org/id/BAE78117 EnsemblBacteria BAE78117 http://www.ensemblgenomes.org/id/BAE78117 EnsemblBacteria b4115 http://www.ensemblgenomes.org/id/b4115 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015179 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015179 GO_function GO:0015181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015181 GO_function GO:0015297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015297 GO_process GO:0003333 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003333 GO_process GO:0051454 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051454 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 948628 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948628 HOGENOM HOG000164506 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000164506&db=HOGENOM6 InParanoid P60061 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P60061 InterPro IPR002293 http://www.ebi.ac.uk/interpro/entry/IPR002293 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW4076 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4076 KEGG_Gene eco:b4115 http://www.genome.jp/dbget-bin/www_bget?eco:b4115 KEGG_Orthology KO:K03759 http://www.genome.jp/dbget-bin/www_bget?KO:K03759 OMA NAWISPS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NAWISPS PANTHER PTHR11785 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11785 PDB 3OB6 http://www.ebi.ac.uk/pdbe-srv/view/entry/3OB6 PDB 5J4I http://www.ebi.ac.uk/pdbe-srv/view/entry/5J4I PDB 5J4N http://www.ebi.ac.uk/pdbe-srv/view/entry/5J4N PDBsum 3OB6 http://www.ebi.ac.uk/pdbsum/3OB6 PDBsum 5J4I http://www.ebi.ac.uk/pdbsum/5J4I PDBsum 5J4N http://www.ebi.ac.uk/pdbsum/5J4N PSORT swissprot:ADIC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ADIC_ECOLI PSORT-B swissprot:ADIC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ADIC_ECOLI PSORT2 swissprot:ADIC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ADIC_ECOLI Pfam PF13520 http://pfam.xfam.org/family/PF13520 Phobius swissprot:ADIC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ADIC_ECOLI PhylomeDB P60061 http://phylomedb.org/?seqid=P60061 ProteinModelPortal P60061 http://www.proteinmodelportal.org/query/uniprot/P60061 PubMed 12867448 http://www.ncbi.nlm.nih.gov/pubmed/12867448 PubMed 14594828 http://www.ncbi.nlm.nih.gov/pubmed/14594828 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418539 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418539 RefSeq WP_000093154 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000093154 SMR P60061 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P60061 STRING 511145.b4115 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4115&targetmode=cogs STRING COG0531 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0531&targetmode=cogs TCDB 2.A.3.2 http://www.tcdb.org/search/result.php?tc=2.A.3.2 UniProtKB ADIC_ECOLI http://www.uniprot.org/uniprot/ADIC_ECOLI UniProtKB-AC P60061 http://www.uniprot.org/uniprot/P60061 charge swissprot:ADIC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ADIC_ECOLI eggNOG COG0531 http://eggnogapi.embl.de/nog_data/html/tree/COG0531 eggNOG ENOG4105D5Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D5Q epestfind swissprot:ADIC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ADIC_ECOLI garnier swissprot:ADIC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ADIC_ECOLI helixturnhelix swissprot:ADIC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ADIC_ECOLI hmoment swissprot:ADIC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ADIC_ECOLI iep swissprot:ADIC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ADIC_ECOLI inforesidue swissprot:ADIC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ADIC_ECOLI octanol swissprot:ADIC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ADIC_ECOLI pepcoil swissprot:ADIC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ADIC_ECOLI pepdigest swissprot:ADIC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ADIC_ECOLI pepinfo swissprot:ADIC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ADIC_ECOLI pepnet swissprot:ADIC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ADIC_ECOLI pepstats swissprot:ADIC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ADIC_ECOLI pepwheel swissprot:ADIC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ADIC_ECOLI pepwindow swissprot:ADIC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ADIC_ECOLI sigcleave swissprot:ADIC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ADIC_ECOLI ## Database ID URL or Descriptions # AltName SYC_ECOLI Cysteinyl-tRNA synthetase # BRENDA 6.1.1.16 2026 # BioGrid 4262015 12 # CATALYTIC ACTIVITY SYC_ECOLI ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys). # CDD cd00672 CysRS_core # COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI 29105; Note=Binds 1 zinc ion per subunit.; # EcoGene EG10196 cysS # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004812 aminoacyl-tRNA ligase activity; IDA:EcoliWiki. # GO_function GO:0004817 cysteine-tRNA ligase activity; IDA:EcoliWiki. # GO_function GO:0005524 ATP binding; IPI:EcoliWiki. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_function GO:0016874 ligase activity; IDA:EcoliWiki. # GO_function GO:0046872 metal ion binding; IPI:EcoliWiki. # GO_process GO:0006423 cysteinyl-tRNA aminoacylation; IDA:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0006520 cellular amino acid metabolic process # Gene3D 3.40.50.620 -; 1. # HAMAP MF_00041 Cys_tRNA_synth # IntAct P21888 3 # InterPro IPR009080 tRNAsynth_Ia_anticodon-bd # InterPro IPR014729 Rossmann-like_a/b/a_fold # InterPro IPR015273 Cys-tRNA-synt_Ia_DALR # InterPro IPR015803 Cys-tRNA-ligase # InterPro IPR024909 Cys-tRNA/MSH_ligase # InterPro IPR032678 tRNA-synt_1_cat_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01007 Amino acid related enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # KEGG_Pathway ko00970 Aminoacyl-tRNA biosynthesis # Organism SYC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10890 PTHR10890 # PATRIC 32116212 VBIEscCol129921_0547 # PDB 1LI5 X-ray; 2.30 A; A/B=1-461 # PDB 1LI7 X-ray; 2.60 A; A/B=1-461 # PDB 1U0B X-ray; 2.30 A; B=1-461 # PIR A37868 YYEC # PRINTS PR00983 TRNASYNTHCYS # Pfam PF01406 tRNA-synt_1e # Pfam PF09190 DALR_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SYC_ECOLI Cysteine--tRNA ligase # RefSeq NP_415059 NC_000913.3 # RefSeq WP_000912385 NZ_LN832404.1 # SIMILARITY Belongs to the class-I aminoacyl-tRNA synthetase family. {ECO 0000305}. # SMART SM00840 DALR_2 # SUBCELLULAR LOCATION SYC_ECOLI Cytoplasm. # SUBUNIT SYC_ECOLI Monomer. # SUPFAM SSF47323 SSF47323 # TIGRFAMs TIGR00435 cysS # eggNOG COG0215 LUCA # eggNOG ENOG4105C8N Bacteria BLAST swissprot:SYC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SYC_ECOLI BioCyc ECOL316407:JW0515-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0515-MONOMER BioCyc EcoCyc:CYSS-MONOMER http://biocyc.org/getid?id=EcoCyc:CYSS-MONOMER BioCyc MetaCyc:CYSS-MONOMER http://biocyc.org/getid?id=MetaCyc:CYSS-MONOMER COG COG0215 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0215 DOI 10.1016/0014-5793(91)80968-9 http://dx.doi.org/10.1016/0014-5793(91)80968-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.88.3.976 http://dx.doi.org/10.1073/pnas.88.3.976 DOI 10.1093/emboj/21.11.2778 http://dx.doi.org/10.1093/emboj/21.11.2778 DOI 10.1093/nar/19.2.265 http://dx.doi.org/10.1093/nar/19.2.265 DOI 10.1107/S0907444999001468 http://dx.doi.org/10.1107/S0907444999001468 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.1.1.16 http://www.genome.jp/dbget-bin/www_bget?EC:6.1.1.16 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M59381 http://www.ebi.ac.uk/ena/data/view/M59381 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL X56234 http://www.ebi.ac.uk/ena/data/view/X56234 EMBL X59293 http://www.ebi.ac.uk/ena/data/view/X59293 ENZYME 6.1.1.16 http://enzyme.expasy.org/EC/6.1.1.16 EchoBASE EB0193 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0193 EcoGene EG10196 http://www.ecogene.org/geneInfo.php?eg_id=EG10196 EnsemblBacteria AAC73628 http://www.ensemblgenomes.org/id/AAC73628 EnsemblBacteria AAC73628 http://www.ensemblgenomes.org/id/AAC73628 EnsemblBacteria BAE76303 http://www.ensemblgenomes.org/id/BAE76303 EnsemblBacteria BAE76303 http://www.ensemblgenomes.org/id/BAE76303 EnsemblBacteria BAE76303 http://www.ensemblgenomes.org/id/BAE76303 EnsemblBacteria b0526 http://www.ensemblgenomes.org/id/b0526 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004812 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004812 GO_function GO:0004817 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004817 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006423 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006423 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 GeneID 946969 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946969 HAMAP MF_00041 http://hamap.expasy.org/unirule/MF_00041 HOGENOM HOG000245250 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000245250&db=HOGENOM6 InParanoid P21888 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P21888 IntAct P21888 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P21888* IntEnz 6.1.1.16 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.1.1.16 InterPro IPR009080 http://www.ebi.ac.uk/interpro/entry/IPR009080 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 InterPro IPR015273 http://www.ebi.ac.uk/interpro/entry/IPR015273 InterPro IPR015803 http://www.ebi.ac.uk/interpro/entry/IPR015803 InterPro IPR024909 http://www.ebi.ac.uk/interpro/entry/IPR024909 InterPro IPR032678 http://www.ebi.ac.uk/interpro/entry/IPR032678 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW0515 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0515 KEGG_Gene eco:b0526 http://www.genome.jp/dbget-bin/www_bget?eco:b0526 KEGG_Orthology KO:K01883 http://www.genome.jp/dbget-bin/www_bget?KO:K01883 KEGG_Pathway ko00970 http://www.genome.jp/kegg-bin/show_pathway?ko00970 KEGG_Reaction rn:R03650 http://www.genome.jp/dbget-bin/www_bget?rn:R03650 MINT MINT-1240309 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1240309 OMA YQIDIHA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YQIDIHA PANTHER PTHR10890 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10890 PDB 1LI5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1LI5 PDB 1LI7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1LI7 PDB 1U0B http://www.ebi.ac.uk/pdbe-srv/view/entry/1U0B PDBsum 1LI5 http://www.ebi.ac.uk/pdbsum/1LI5 PDBsum 1LI7 http://www.ebi.ac.uk/pdbsum/1LI7 PDBsum 1U0B http://www.ebi.ac.uk/pdbsum/1U0B PRINTS PR00983 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00983 PSORT swissprot:SYC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SYC_ECOLI PSORT-B swissprot:SYC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SYC_ECOLI PSORT2 swissprot:SYC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SYC_ECOLI Pfam PF01406 http://pfam.xfam.org/family/PF01406 Pfam PF09190 http://pfam.xfam.org/family/PF09190 Phobius swissprot:SYC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SYC_ECOLI PhylomeDB P21888 http://phylomedb.org/?seqid=P21888 ProteinModelPortal P21888 http://www.proteinmodelportal.org/query/uniprot/P21888 PubMed 10216301 http://www.ncbi.nlm.nih.gov/pubmed/10216301 PubMed 12032090 http://www.ncbi.nlm.nih.gov/pubmed/12032090 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1864365 http://www.ncbi.nlm.nih.gov/pubmed/1864365 PubMed 1992490 http://www.ncbi.nlm.nih.gov/pubmed/1992490 PubMed 2014166 http://www.ncbi.nlm.nih.gov/pubmed/2014166 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415059 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415059 RefSeq WP_000912385 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000912385 SMART SM00840 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00840 SMR P21888 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P21888 STRING 511145.b0526 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0526&targetmode=cogs STRING COG0215 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0215&targetmode=cogs SUPFAM SSF47323 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47323 TIGRFAMs TIGR00435 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00435 UniProtKB SYC_ECOLI http://www.uniprot.org/uniprot/SYC_ECOLI UniProtKB-AC P21888 http://www.uniprot.org/uniprot/P21888 charge swissprot:SYC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SYC_ECOLI eggNOG COG0215 http://eggnogapi.embl.de/nog_data/html/tree/COG0215 eggNOG ENOG4105C8N http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C8N epestfind swissprot:SYC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SYC_ECOLI garnier swissprot:SYC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SYC_ECOLI helixturnhelix swissprot:SYC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SYC_ECOLI hmoment swissprot:SYC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SYC_ECOLI iep swissprot:SYC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SYC_ECOLI inforesidue swissprot:SYC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SYC_ECOLI octanol swissprot:SYC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SYC_ECOLI pepcoil swissprot:SYC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SYC_ECOLI pepdigest swissprot:SYC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SYC_ECOLI pepinfo swissprot:SYC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SYC_ECOLI pepnet swissprot:SYC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SYC_ECOLI pepstats swissprot:SYC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SYC_ECOLI pepwheel swissprot:SYC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SYC_ECOLI pepwindow swissprot:SYC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SYC_ECOLI sigcleave swissprot:SYC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SYC_ECOLI ## Database ID URL or Descriptions # BioGrid 4261751 6 # COFACTOR C56I_ECOLI Name=heme b; Xref=ChEBI CHEBI 60344; Evidence={ECO 0000250}; Note=Binds 2 heme B (iron-protoporphyrin IX) groups per molecule. {ECO 0000250}; # EcoGene EG12659 yceJ # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0009055 electron carrier activity; IEA:InterPro. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0022904 respiratory electron transport chain; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # InterPro IPR011577 Cyt_b561_bac/Ni-Hgenase # InterPro IPR016174 Di-haem_cyt_TM # Organism C56I_ECOLI Escherichia coli (strain K12) # PATRIC 32117351 VBIEscCol129921_1098 # PIR F64848 F64848 # Pfam PF01292 Ni_hydr_CYTB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName C56I_ECOLI Cytochrome b561 homolog 2 # RefSeq NP_415575 NC_000913.3 # RefSeq WP_000011114 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA06517.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the cytochrome b561 family. {ECO 0000305}. # SUBCELLULAR LOCATION C56I_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF81342 SSF81342 # eggNOG COG3038 LUCA # eggNOG ENOG4105DS1 Bacteria BLAST swissprot:C56I_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:C56I_ECOLI BioCyc ECOL316407:JW1044-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1044-MONOMER BioCyc EcoCyc:G6554-MONOMER http://biocyc.org/getid?id=EcoCyc:G6554-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D31709 http://www.ebi.ac.uk/ena/data/view/D31709 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2526 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2526 EcoGene EG12659 http://www.ecogene.org/geneInfo.php?eg_id=EG12659 EnsemblBacteria AAC74141 http://www.ensemblgenomes.org/id/AAC74141 EnsemblBacteria AAC74141 http://www.ensemblgenomes.org/id/AAC74141 EnsemblBacteria BAA35855 http://www.ensemblgenomes.org/id/BAA35855 EnsemblBacteria BAA35855 http://www.ensemblgenomes.org/id/BAA35855 EnsemblBacteria BAA35855 http://www.ensemblgenomes.org/id/BAA35855 EnsemblBacteria b1057 http://www.ensemblgenomes.org/id/b1057 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0022904 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022904 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GeneID 945628 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945628 HOGENOM HOG000110385 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000110385&db=HOGENOM6 InParanoid P75925 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75925 InterPro IPR011577 http://www.ebi.ac.uk/interpro/entry/IPR011577 InterPro IPR016174 http://www.ebi.ac.uk/interpro/entry/IPR016174 KEGG_Gene ecj:JW1044 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1044 KEGG_Gene eco:b1057 http://www.genome.jp/dbget-bin/www_bget?eco:b1057 OMA WYKTAPH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WYKTAPH PSORT swissprot:C56I_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:C56I_ECOLI PSORT-B swissprot:C56I_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:C56I_ECOLI PSORT2 swissprot:C56I_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:C56I_ECOLI Pfam PF01292 http://pfam.xfam.org/family/PF01292 Phobius swissprot:C56I_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:C56I_ECOLI PhylomeDB P75925 http://phylomedb.org/?seqid=P75925 ProteinModelPortal P75925 http://www.proteinmodelportal.org/query/uniprot/P75925 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415575 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415575 RefSeq WP_000011114 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000011114 STRING 511145.b1057 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1057&targetmode=cogs SUPFAM SSF81342 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81342 UniProtKB C56I_ECOLI http://www.uniprot.org/uniprot/C56I_ECOLI UniProtKB-AC P75925 http://www.uniprot.org/uniprot/P75925 charge swissprot:C56I_ECOLI http://rest.g-language.org/emboss/charge/swissprot:C56I_ECOLI eggNOG COG3038 http://eggnogapi.embl.de/nog_data/html/tree/COG3038 eggNOG ENOG4105DS1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DS1 epestfind swissprot:C56I_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:C56I_ECOLI garnier swissprot:C56I_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:C56I_ECOLI helixturnhelix swissprot:C56I_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:C56I_ECOLI hmoment swissprot:C56I_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:C56I_ECOLI iep swissprot:C56I_ECOLI http://rest.g-language.org/emboss/iep/swissprot:C56I_ECOLI inforesidue swissprot:C56I_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:C56I_ECOLI octanol swissprot:C56I_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:C56I_ECOLI pepcoil swissprot:C56I_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:C56I_ECOLI pepdigest swissprot:C56I_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:C56I_ECOLI pepinfo swissprot:C56I_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:C56I_ECOLI pepnet swissprot:C56I_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:C56I_ECOLI pepstats swissprot:C56I_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:C56I_ECOLI pepwheel swissprot:C56I_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:C56I_ECOLI pepwindow swissprot:C56I_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:C56I_ECOLI sigcleave swissprot:C56I_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:C56I_ECOLI ## Database ID URL or Descriptions # BioGrid 4259650 11 # CATALYTIC ACTIVITY 2 GTP = 2 diphosphate + cyclic di-3',5'- guanylate. {ECO:0000269|PubMed 17010156}. # CDD cd01949 GGDEF # COFACTOR YDAM_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250}; Note=Binds 1 Mg(2+) ion per monomer. {ECO 0000250}; # DISRUPTION PHENOTYPE YDAM_ECOLI Loss of curli fimbriae, decreased biofilm formation, decreased expression of AdrA, a probable diguanylate cyclase and of the curli regulator CsgD. {ECO 0000269|PubMed 17010156, ECO 0000269|PubMed 19332833}. # EcoGene EG13355 ydaM # FUNCTION YDAM_ECOLI Part of a 2 protein system that seems to be dedicated to regulate transcription of csgD. The CsdG protein in turn regulates expression of adhesive curli fimbriae genes csgEFG, csgBAC/ymaD and adrA (yaic). Activity of this protein is antagonized by the phosphodiesterase Gmr (YciR). In vitro has weak diguanylate cyclase activity. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria. {ECO 0000269|PubMed 17010156}. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_function GO:0000155 phosphorelay sensor kinase activity; IEA:InterPro. # GO_function GO:0005525 GTP binding; IEA:UniProtKB-KW. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0052621 diguanylate cyclase activity; IDA:EcoCyc. # GO_process GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity; IMP:EcoCyc. # GO_process GO:1900233 positive regulation of single-species biofilm formation on inanimate substrate; IMP:EcoCyc. # GOslim_component GO:0005622 intracellular # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # INDUCTION YDAM_ECOLI Expressed during transition into stationary phase, expression is higher at 28 than 37 degrees Celsius, more highly expressed on plates than in liquid medium. In rich medium YdaM and DosC are the major RpoS-dependent GGDEF-domain containing proteins in the cell. Expression is RpoS and HNS dependent. {ECO 0000269|PubMed 17010156, ECO 0000269|PubMed 19332833}. # INTERACTION YDAM_ECOLI Self; NbExp=3; IntAct=EBI-544662, EBI-544662; P77334 gmr; NbExp=5; IntAct=EBI-544662, EBI-548149; P33358 mlrA; NbExp=2; IntAct=EBI-544662, EBI-1127668; # IntAct P77302 6 # InterPro IPR000014 PAS # InterPro IPR000160 GGDEF_dom # InterPro IPR000700 PAS-assoc_C # InterPro IPR013656 PAS_4 # InterPro IPR029787 Nucleotide_cyclase # Organism YDAM_ECOLI Escherichia coli (strain K12) # PATHWAY YDAM_ECOLI Purine metabolism; 3',5'-cyclic di-GMP biosynthesis. # PATRIC 32117960 VBIEscCol129921_1400 # PIR H64883 H64883 # PROSITE PS50113 PAC # PROSITE PS50887 GGDEF # Pfam PF00990 GGDEF # Pfam PF08448 PAS_4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDAM_ECOLI Probable diguanylate cyclase YdaM # RefSeq NP_415857 NC_000913.3 # RefSeq WP_000628058 NZ_LN832404.1 # SIMILARITY Contains 1 GGDEF domain. {ECO:0000255|PROSITE- ProRule PRU00095}. # SIMILARITY Contains 1 PAC (PAS-associated C-terminal) domain. {ECO:0000255|PROSITE-ProRule PRU00141}. # SIMILARITY Contains 2 PAS (PER-ARNT-SIM) domains. {ECO 0000305}. # SMART SM00091 PAS; 2 # SMART SM00267 GGDEF # SUBUNIT Homodimer. {ECO 0000250}. # SUPFAM SSF55073 SSF55073 # SUPFAM SSF55785 SSF55785 # TIGRFAMs TIGR00229 sensory_box # TIGRFAMs TIGR00254 GGDEF # eggNOG COG2199 LUCA # eggNOG COG2202 LUCA # eggNOG ENOG4105BZU Bacteria BLAST swissprot:YDAM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDAM_ECOLI BioCyc ECOL316407:JW5206-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5206-MONOMER BioCyc EcoCyc:G6673-MONOMER http://biocyc.org/getid?id=EcoCyc:G6673-MONOMER BioCyc MetaCyc:G6673-MONOMER http://biocyc.org/getid?id=MetaCyc:G6673-MONOMER DIP DIP-28053N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-28053N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1099/mic.0.024257-0 http://dx.doi.org/10.1099/mic.0.024257-0 DOI 10.1111/j.1365-2958.2006.05440.x http://dx.doi.org/10.1111/j.1365-2958.2006.05440.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.7.65 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.65 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.7.65 http://enzyme.expasy.org/EC/2.7.7.65 EchoBASE EB3138 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3138 EcoGene EG13355 http://www.ecogene.org/geneInfo.php?eg_id=EG13355 EnsemblBacteria AAC74423 http://www.ensemblgenomes.org/id/AAC74423 EnsemblBacteria AAC74423 http://www.ensemblgenomes.org/id/AAC74423 EnsemblBacteria BAA14945 http://www.ensemblgenomes.org/id/BAA14945 EnsemblBacteria BAA14945 http://www.ensemblgenomes.org/id/BAA14945 EnsemblBacteria BAA14945 http://www.ensemblgenomes.org/id/BAA14945 EnsemblBacteria b1341 http://www.ensemblgenomes.org/id/b1341 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_function GO:0000155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000155 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0052621 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052621 GO_process GO:0051091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051091 GO_process GO:1900233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1900233 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 945909 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945909 HOGENOM HOG000120131 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120131&db=HOGENOM6 InParanoid P77302 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77302 IntAct P77302 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77302* IntEnz 2.7.7.65 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.65 InterPro IPR000014 http://www.ebi.ac.uk/interpro/entry/IPR000014 InterPro IPR000160 http://www.ebi.ac.uk/interpro/entry/IPR000160 InterPro IPR000700 http://www.ebi.ac.uk/interpro/entry/IPR000700 InterPro IPR013656 http://www.ebi.ac.uk/interpro/entry/IPR013656 InterPro IPR029787 http://www.ebi.ac.uk/interpro/entry/IPR029787 KEGG_Gene ecj:JW5206 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5206 KEGG_Gene eco:b1341 http://www.genome.jp/dbget-bin/www_bget?eco:b1341 OMA KLMLCII http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KLMLCII PROSITE PS50113 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50113 PROSITE PS50887 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50887 PSORT swissprot:YDAM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDAM_ECOLI PSORT-B swissprot:YDAM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDAM_ECOLI PSORT2 swissprot:YDAM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDAM_ECOLI Pfam PF00990 http://pfam.xfam.org/family/PF00990 Pfam PF08448 http://pfam.xfam.org/family/PF08448 Phobius swissprot:YDAM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDAM_ECOLI PhylomeDB P77302 http://phylomedb.org/?seqid=P77302 ProteinModelPortal P77302 http://www.proteinmodelportal.org/query/uniprot/P77302 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17010156 http://www.ncbi.nlm.nih.gov/pubmed/17010156 PubMed 19332833 http://www.ncbi.nlm.nih.gov/pubmed/19332833 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415857 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415857 RefSeq WP_000628058 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000628058 SMART SM00091 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00091 SMART SM00267 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00267 SMR P77302 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77302 STRING 511145.b1341 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1341&targetmode=cogs SUPFAM SSF55073 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55073 SUPFAM SSF55785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55785 TIGRFAMs TIGR00229 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00229 TIGRFAMs TIGR00254 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00254 UniProtKB YDAM_ECOLI http://www.uniprot.org/uniprot/YDAM_ECOLI UniProtKB-AC P77302 http://www.uniprot.org/uniprot/P77302 charge swissprot:YDAM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDAM_ECOLI eggNOG COG2199 http://eggnogapi.embl.de/nog_data/html/tree/COG2199 eggNOG COG2202 http://eggnogapi.embl.de/nog_data/html/tree/COG2202 eggNOG ENOG4105BZU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZU epestfind swissprot:YDAM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDAM_ECOLI garnier swissprot:YDAM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDAM_ECOLI helixturnhelix swissprot:YDAM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDAM_ECOLI hmoment swissprot:YDAM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDAM_ECOLI iep swissprot:YDAM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDAM_ECOLI inforesidue swissprot:YDAM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDAM_ECOLI octanol swissprot:YDAM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDAM_ECOLI pepcoil swissprot:YDAM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDAM_ECOLI pepdigest swissprot:YDAM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDAM_ECOLI pepinfo swissprot:YDAM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDAM_ECOLI pepnet swissprot:YDAM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDAM_ECOLI pepstats swissprot:YDAM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDAM_ECOLI pepwheel swissprot:YDAM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDAM_ECOLI pepwindow swissprot:YDAM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDAM_ECOLI sigcleave swissprot:YDAM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDAM_ECOLI ## Database ID URL or Descriptions # BRENDA 3.6.3.43 2026 # BioGrid 4260260 252 # CDD cd06174 MFS # EcoGene EG13939 dtpA # FUNCTION DTPA_ECOLI Proton-dependent permease that transports di- and tripeptides as well as structurally related peptidomimetics such as aminocephalosporins into the cell. Has a clear preference for dipeptides and tripeptides composed of L-amino acids, and discriminates dipeptides on the basis of the position of charges within the substrate. {ECO 0000269|PubMed 15175316, ECO 0000269|PubMed 17158458, ECO 0000269|PubMed 18485005}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IDA:EcoliWiki. # GO_function DTPA_ECOLI GO 0015333 peptide proton symporter activity; IDA EcoCyc. # GO_function GO:0015078 hydrogen ion transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0015293 symporter activity; IDA:EcoliWiki. # GO_function GO:0042895 antibiotic transporter activity; IMP:EcoCyc. # GO_function GO:0042937 tripeptide transporter activity; IMP:EcoCyc. # GO_function GO:0071916 dipeptide transmembrane transporter activity; IDA:EcoCyc. # GO_process GO:0006857 oligopeptide transport; IDA:EcoliWiki. # GO_process GO:0015031 protein transport; IEA:UniProtKB-KW. # GO_process GO:0035442 dipeptide transmembrane transport; IDA:EcoCyc. # GO_process GO:0035443 tripeptide transmembrane transport; IMP:EcoCyc. # GO_process GO:0042891 antibiotic transport; IMP:EcoCyc. # GO_process GO:1902600 hydrogen ion transmembrane transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # HAMAP MF_01878 PTR2_DtpA_subfam # INDUCTION Transcriptionally activated by the EnvZ/OmpR regulatory system. {ECO:0000269|PubMed 15175316}. # InterPro IPR000109 POT_fam # InterPro IPR005279 Dipep/tripep_permease # InterPro IPR018456 PTR2_symporter_CS # InterPro IPR020846 MFS_dom # InterPro IPR023517 AA/pep_transptr_DtpA # Organism DTPA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11654 PTHR11654 # PATRIC 32118570 VBIEscCol129921_1705 # PIR D64920 D64920 # PROSITE PS01022 PTR2_1 # PROSITE PS01023 PTR2_2 # PROSITE PS50850 MFS # Pfam PF00854 PTR2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DTPA_ECOLI Dipeptide and tripeptide permease A # RefSeq NP_416151 NC_000913.3 # RefSeq WP_000100932 NZ_LN832404.1 # SIMILARITY Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpA subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION DTPA_ECOLI Cell inner membrane {ECO 0000305}; Multi- pass membrane protein {ECO 0000305}. # SUBUNIT Monomer (Probable). Has a crown-like structure with a diameter of 8 nm and a central density. {ECO:0000269|PubMed 17158458, ECO:0000305}. # SUPFAM SSF103473 SSF103473; 2 # TCDB 2.A.17.1 the proton-dependent oligopeptide transporter (pot/ptr) family # TIGRFAMs TIGR00924 yjdL_sub1_fam # eggNOG COG3104 LUCA # eggNOG ENOG4105DUX Bacteria BLAST swissprot:DTPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DTPA_ECOLI BioCyc ECOL316407:JW1626-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1626-MONOMER BioCyc EcoCyc:B1634-MONOMER http://biocyc.org/getid?id=EcoCyc:B1634-MONOMER BioCyc MetaCyc:B1634-MONOMER http://biocyc.org/getid?id=MetaCyc:B1634-MONOMER COG COG3104 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3104 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M604866200 http://dx.doi.org/10.1074/jbc.M604866200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1111/j.1742-4658.2008.06477.x http://dx.doi.org/10.1111/j.1742-4658.2008.06477.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.186.12.4019-4024.2004 http://dx.doi.org/10.1128/JB.186.12.4019-4024.2004 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3698 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3698 EcoGene EG13939 http://www.ecogene.org/geneInfo.php?eg_id=EG13939 EnsemblBacteria AAC74706 http://www.ensemblgenomes.org/id/AAC74706 EnsemblBacteria AAC74706 http://www.ensemblgenomes.org/id/AAC74706 EnsemblBacteria BAA15395 http://www.ensemblgenomes.org/id/BAA15395 EnsemblBacteria BAA15395 http://www.ensemblgenomes.org/id/BAA15395 EnsemblBacteria BAA15395 http://www.ensemblgenomes.org/id/BAA15395 EnsemblBacteria b1634 http://www.ensemblgenomes.org/id/b1634 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015078 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015078 GO_function GO:0015293 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293 GO_function GO:0015333 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015333 GO_function GO:0042895 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042895 GO_function GO:0042937 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042937 GO_function GO:0071916 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071916 GO_process GO:0006857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006857 GO_process GO:0015031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031 GO_process GO:0035442 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035442 GO_process GO:0035443 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035443 GO_process GO:0042891 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042891 GO_process GO:1902600 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902600 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 947436 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947436 HAMAP MF_01878 http://hamap.expasy.org/unirule/MF_01878 HOGENOM HOG000243449 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000243449&db=HOGENOM6 InParanoid P77304 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77304 InterPro IPR000109 http://www.ebi.ac.uk/interpro/entry/IPR000109 InterPro IPR005279 http://www.ebi.ac.uk/interpro/entry/IPR005279 InterPro IPR018456 http://www.ebi.ac.uk/interpro/entry/IPR018456 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 InterPro IPR023517 http://www.ebi.ac.uk/interpro/entry/IPR023517 KEGG_Gene ecj:JW1626 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1626 KEGG_Gene eco:b1634 http://www.genome.jp/dbget-bin/www_bget?eco:b1634 KEGG_Orthology KO:K03305 http://www.genome.jp/dbget-bin/www_bget?KO:K03305 OMA WLLHNQG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WLLHNQG PANTHER PTHR11654 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11654 PROSITE PS01022 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01022 PROSITE PS01023 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01023 PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:DTPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DTPA_ECOLI PSORT-B swissprot:DTPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DTPA_ECOLI PSORT2 swissprot:DTPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DTPA_ECOLI Pfam PF00854 http://pfam.xfam.org/family/PF00854 Phobius swissprot:DTPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DTPA_ECOLI PhylomeDB P77304 http://phylomedb.org/?seqid=P77304 ProteinModelPortal P77304 http://www.proteinmodelportal.org/query/uniprot/P77304 PubMed 15175316 http://www.ncbi.nlm.nih.gov/pubmed/15175316 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17158458 http://www.ncbi.nlm.nih.gov/pubmed/17158458 PubMed 18485005 http://www.ncbi.nlm.nih.gov/pubmed/18485005 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416151 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416151 RefSeq WP_000100932 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000100932 STRING 511145.b1634 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1634&targetmode=cogs STRING COG3104 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3104&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.17.1 http://www.tcdb.org/search/result.php?tc=2.A.17.1 TIGRFAMs TIGR00924 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00924 UniProtKB DTPA_ECOLI http://www.uniprot.org/uniprot/DTPA_ECOLI UniProtKB-AC P77304 http://www.uniprot.org/uniprot/P77304 charge swissprot:DTPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DTPA_ECOLI eggNOG COG3104 http://eggnogapi.embl.de/nog_data/html/tree/COG3104 eggNOG ENOG4105DUX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DUX epestfind swissprot:DTPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DTPA_ECOLI garnier swissprot:DTPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DTPA_ECOLI helixturnhelix swissprot:DTPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DTPA_ECOLI hmoment swissprot:DTPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DTPA_ECOLI iep swissprot:DTPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DTPA_ECOLI inforesidue swissprot:DTPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DTPA_ECOLI octanol swissprot:DTPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DTPA_ECOLI pepcoil swissprot:DTPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DTPA_ECOLI pepdigest swissprot:DTPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DTPA_ECOLI pepinfo swissprot:DTPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DTPA_ECOLI pepnet swissprot:DTPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DTPA_ECOLI pepstats swissprot:DTPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DTPA_ECOLI pepwheel swissprot:DTPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DTPA_ECOLI pepwindow swissprot:DTPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DTPA_ECOLI sigcleave swissprot:DTPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DTPA_ECOLI ## Database ID URL or Descriptions # AltName ACTP_ECOLI Acetate permease # AltName ACTP_ECOLI Acetate transporter ActP # BIOPHYSICOCHEMICAL PROPERTIES ACTP_ECOLI Kinetic parameters KM=5.4 uM for acetate {ECO 0000269|PubMed 14563880}; Vmax=19.6 nmol/min/mg enzyme {ECO 0000269|PubMed 14563880}; # BioGrid 4259431 12 # EcoGene EG11942 actP # FUNCTION ACTP_ECOLI Transports acetate. Also able to transport glycolate. {ECO 0000269|PubMed 14563880}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_function GO:0015123 acetate transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0015293 symporter activity; IBA:GO_Central. # GO_function GO:0015654 tellurite uptake transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0043879 glycolate transmembrane transporter activity; IEA:InterPro. # GO_process GO:0006814 sodium ion transport; IEA:UniProtKB-KW. # GO_process GO:0006847 plasma membrane acetate transport; IDA:EcoCyc. # GO_process GO:0015710 tellurite transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # HAMAP MF_01426 Acet_symport_ActP # InterPro IPR001734 Na/solute_symporter # InterPro IPR014083 Cation/Ac_symporter_ActP # InterPro IPR018212 Na/solute_symporter_CS # MISCELLANEOUS ACTP_ECOLI Although ActP belongs to the sodium solute symporter family, the experiments did not allow to show that acetate transport depends on sodium. The inhibition of acetate transport by the uncoupler CCCP indicates that the driving force used by ActP is a transmembrane electrochemical potential. However, it does not allow to discriminate between hydrogen ion or sodium ion-coupled transporters (PubMed 14563880). {ECO 0000305|PubMed 14563880}. # Organism ACTP_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11819 PTHR11819 # PATRIC 32123683 VBIEscCol129921_4190 # PIR B65215 B65215 # PROSITE PS00456 NA_SOLUT_SYMP_1 # PROSITE PS00457 NA_SOLUT_SYMP_2 # PROSITE PS50283 NA_SOLUT_SYMP_3 # Pfam PF00474 SSF # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ACTP_ECOLI Cation/acetate symporter ActP # RefSeq NP_418491 NC_000913.3 # RefSeq WP_000832573 NZ_LN832404.1 # SIMILARITY Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. {ECO 0000305}. # SUBCELLULAR LOCATION ACTP_ECOLI Cell inner membrane {ECO 0000269|PubMed 16079137}; Multi-pass membrane protein {ECO 0000269|PubMed 16079137}. # SUBUNIT Has been isolated from inner membrane preparations as a homodimer. {ECO:0000269|PubMed 16079137}. # TCDB 2.A.21.7:the solute sodium symporter (sss) family # TIGRFAMs TIGR00813 sss # TIGRFAMs TIGR02711 symport_actP # eggNOG COG4147 LUCA # eggNOG ENOG4107QN1 Bacteria BLAST swissprot:ACTP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ACTP_ECOLI BioCyc ECOL316407:JW4028-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4028-MONOMER BioCyc EcoCyc:YJCG-MONOMER http://biocyc.org/getid?id=EcoCyc:YJCG-MONOMER BioCyc MetaCyc:YJCG-MONOMER http://biocyc.org/getid?id=MetaCyc:YJCG-MONOMER COG COG4147 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4147 DIP DIP-12552N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12552N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.185.21.6448-6455.2003 http://dx.doi.org/10.1128/JB.185.21.6448-6455.2003 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1886 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1886 EcoGene EG11942 http://www.ecogene.org/geneInfo.php?eg_id=EG11942 EnsemblBacteria AAC77037 http://www.ensemblgenomes.org/id/AAC77037 EnsemblBacteria AAC77037 http://www.ensemblgenomes.org/id/AAC77037 EnsemblBacteria BAE78069 http://www.ensemblgenomes.org/id/BAE78069 EnsemblBacteria BAE78069 http://www.ensemblgenomes.org/id/BAE78069 EnsemblBacteria BAE78069 http://www.ensemblgenomes.org/id/BAE78069 EnsemblBacteria b4067 http://www.ensemblgenomes.org/id/b4067 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015123 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015123 GO_function GO:0015293 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293 GO_function GO:0015654 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015654 GO_function GO:0043879 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043879 GO_process GO:0006814 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814 GO_process GO:0006847 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006847 GO_process GO:0015710 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015710 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 948575 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948575 HAMAP MF_01426 http://hamap.expasy.org/unirule/MF_01426 HOGENOM HOG000242183 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000242183&db=HOGENOM6 InParanoid P32705 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32705 IntAct P32705 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32705* InterPro IPR001734 http://www.ebi.ac.uk/interpro/entry/IPR001734 InterPro IPR014083 http://www.ebi.ac.uk/interpro/entry/IPR014083 InterPro IPR018212 http://www.ebi.ac.uk/interpro/entry/IPR018212 KEGG_Gene ecj:JW4028 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4028 KEGG_Gene eco:b4067 http://www.genome.jp/dbget-bin/www_bget?eco:b4067 KEGG_Orthology KO:K14393 http://www.genome.jp/dbget-bin/www_bget?KO:K14393 MINT MINT-1259884 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1259884 OMA CAYALFI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CAYALFI PANTHER PTHR11819 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11819 PROSITE PS00456 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00456 PROSITE PS00457 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00457 PROSITE PS50283 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50283 PSORT swissprot:ACTP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ACTP_ECOLI PSORT-B swissprot:ACTP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ACTP_ECOLI PSORT2 swissprot:ACTP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ACTP_ECOLI Pfam PF00474 http://pfam.xfam.org/family/PF00474 Phobius swissprot:ACTP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ACTP_ECOLI PhylomeDB P32705 http://phylomedb.org/?seqid=P32705 ProteinModelPortal P32705 http://www.proteinmodelportal.org/query/uniprot/P32705 PubMed 14563880 http://www.ncbi.nlm.nih.gov/pubmed/14563880 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418491 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418491 RefSeq WP_000832573 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000832573 STRING 511145.b4067 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4067&targetmode=cogs STRING COG4147 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4147&targetmode=cogs TCDB 2.A.21.7 http://www.tcdb.org/search/result.php?tc=2.A.21.7 TIGRFAMs TIGR00813 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00813 TIGRFAMs TIGR02711 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02711 UniProtKB ACTP_ECOLI http://www.uniprot.org/uniprot/ACTP_ECOLI UniProtKB-AC P32705 http://www.uniprot.org/uniprot/P32705 charge swissprot:ACTP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ACTP_ECOLI eggNOG COG4147 http://eggnogapi.embl.de/nog_data/html/tree/COG4147 eggNOG ENOG4107QN1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QN1 epestfind swissprot:ACTP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ACTP_ECOLI garnier swissprot:ACTP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ACTP_ECOLI helixturnhelix swissprot:ACTP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ACTP_ECOLI hmoment swissprot:ACTP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ACTP_ECOLI iep swissprot:ACTP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ACTP_ECOLI inforesidue swissprot:ACTP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ACTP_ECOLI octanol swissprot:ACTP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ACTP_ECOLI pepcoil swissprot:ACTP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ACTP_ECOLI pepdigest swissprot:ACTP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ACTP_ECOLI pepinfo swissprot:ACTP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ACTP_ECOLI pepnet swissprot:ACTP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ACTP_ECOLI pepstats swissprot:ACTP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ACTP_ECOLI pepwheel swissprot:ACTP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ACTP_ECOLI pepwindow swissprot:ACTP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ACTP_ECOLI sigcleave swissprot:ACTP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ACTP_ECOLI ## Database ID URL or Descriptions # AltName CUEO_ECOLI Copper efflux oxidase # BioGrid 4261957 12 # COFACTOR Name=Cu cation; Xref=ChEBI:CHEBI 23378; Note=Binds 4 Cu cations per monomer.; # DOMAIN CUEO_ECOLI The methionine-rich domain could provide binding sites for exogenous copper ions. This methionine-rich region is probably important for copper tolerance in bacteria. # EcoGene EG12318 cueO # FUNCTION CUEO_ECOLI Probably involved in periplasmic detoxification of copper by oxidizing Cu(+) to Cu(2+) and thus preventing its uptake into the cytoplasm. Possesses phenoloxidase and ferroxidase activities and might be involved in the production of polyphenolic compounds and the prevention of oxidative damage in the periplasm. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_component GO:0042597 periplasmic space; IDA:EcoliWiki. # GO_function CUEO_ECOLI GO 0052716 hydroquinone oxygen oxidoreductase activity; IBA GO_Central. # GO_function GO:0005507 copper ion binding; IDA:EcoliWiki. # GO_function GO:0016722 oxidoreductase activity, oxidizing metal ions; IDA:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # Gene3D 2.60.40.420 -; 3. # INDUCTION CUEO_ECOLI By CueR, at increased levels of cytoplasmic cuprous ions. # IntAct P36649 3 # InterPro IPR001117 Cu-oxidase # InterPro IPR002355 Cu_oxidase_Cu_BS # InterPro IPR006311 TAT_signal # InterPro IPR008972 Cupredoxin # InterPro IPR011706 Cu-oxidase_2 # InterPro IPR011707 Cu-oxidase_3 # MISCELLANEOUS CUEO_ECOLI This protein is sensitive to oxygen deprivation. It probably plays a significant role in copper efflux under aerobic conditions. # Organism CUEO_ECOLI Escherichia coli (strain K12) # PATRIC 32115347 VBIEscCol129921_0125 # PDB 1KV7 X-ray; 1.40 A; A=29-516 # PDB 1N68 X-ray; 1.70 A; A=29-516 # PDB 1PF3 X-ray; 1.50 A; A=29-516 # PDB 2FQD X-ray; 2.40 A; A=29-516 # PDB 2FQE X-ray; 1.92 A; A=29-516 # PDB 2FQF X-ray; 2.00 A; A=29-516 # PDB 2FQG X-ray; 2.30 A; A=29-516 # PDB 2YXV X-ray; 1.81 A; A/B=29-516 # PDB 2YXW X-ray; 1.50 A; A/B=29-516 # PDB 3NSC X-ray; 1.50 A; A=29-516 # PDB 3NSD X-ray; 2.00 A; A=29-516 # PDB 3NSF X-ray; 2.00 A; A=29-516 # PDB 3NSY X-ray; 2.10 A; A=29-516 # PDB 3NT0 X-ray; 1.80 A; A=29-516 # PDB 3OD3 X-ray; 1.10 A; A=29-516 # PDB 3PAU X-ray; 2.00 A; A=29-516 # PDB 3PAV X-ray; 1.45 A; A=29-516 # PDB 3QQX X-ray; 1.50 A; A=29-516 # PDB 3UAA X-ray; 1.70 A; A=29-516 # PDB 3UAB X-ray; 1.30 A; A=29-516 # PDB 3UAC X-ray; 1.30 A; A=29-516 # PDB 3UAD X-ray; 1.10 A; A=29-516 # PDB 3UAE X-ray; 1.30 A; A=29-516 # PDB 4E9Q X-ray; 1.30 A; A=29-516 # PDB 4E9R X-ray; 1.30 A; A=29-516 # PDB 4E9S X-ray; 1.06 A; A=29-516 # PDB 4E9T X-ray; 1.30 A; A=29-516 # PDB 4EF3 X-ray; 1.90 A; A=29-516 # PDB 4HAK X-ray; 1.40 A; A=29-516 # PDB 4HAL X-ray; 1.40 A; A=29-516 # PDB 4NER X-ray; 1.60 A; A=29-516 # PDB 5B7E X-ray; 1.42 A; A=1-516 # PDB 5B7F X-ray; 1.45 A; A=29-516 # PDB 5B7M X-ray; 1.80 A; A/B/C=29-516 # PIR C64735 C64735 # PROSITE PS00080 MULTICOPPER_OXIDASE2 # PROSITE PS51318 TAT # PTM CUEO_ECOLI Exported by the Tat system. The position of the signal peptide cleavage has been experimentally proven. Can also be exported by the Sec system. # Pfam PF00394 Cu-oxidase # Pfam PF07731 Cu-oxidase_2 # Pfam PF07732 Cu-oxidase_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CUEO_ECOLI Blue copper oxidase CueO # RefSeq NP_414665 NC_000913.3 # RefSeq WP_001189647 NZ_LN832404.1 # SIMILARITY Belongs to the multicopper oxidase family. {ECO 0000305}. # SIMILARITY Contains 3 plastocyanin-like domains. {ECO 0000305}. # SUBCELLULAR LOCATION CUEO_ECOLI Periplasm. Note=It is exported via the Tat pathway. # SUBUNIT Monomer. {ECO 0000305}. # SUPFAM SSF49503 SSF49503; 4 # TCDB 1.B.76.1 the copper resistance putative porin (copb) family # eggNOG COG2132 LUCA # eggNOG ENOG4105E3B Bacteria BLAST swissprot:CUEO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CUEO_ECOLI BioCyc ECOL316407:JW0119-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0119-MONOMER BioCyc EcoCyc:EG12318-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12318-MONOMER BioCyc MetaCyc:EG12318-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12318-MONOMER COG COG2132 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2132 DIP DIP-11178N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11178N DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/bbrc.2001.5474 http://dx.doi.org/10.1006/bbrc.2001.5474 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.052710499 http://dx.doi.org/10.1073/pnas.052710499 DOI 10.1074/jbc.M006508200 http://dx.doi.org/10.1074/jbc.M006508200 DOI 10.1074/jbc.M104122200 http://dx.doi.org/10.1074/jbc.M104122200 DOI 10.1074/jbc.M610507200 http://dx.doi.org/10.1074/jbc.M610507200 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.183.16.4866-4875.2001 http://dx.doi.org/10.1128/JB.183.16.4866-4875.2001 DOI 10.1128/JB.183.6.2145-2147.2001 http://dx.doi.org/10.1128/JB.183.6.2145-2147.2001 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2223 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2223 EcoGene EG12318 http://www.ecogene.org/geneInfo.php?eg_id=EG12318 EnsemblBacteria AAC73234 http://www.ensemblgenomes.org/id/AAC73234 EnsemblBacteria AAC73234 http://www.ensemblgenomes.org/id/AAC73234 EnsemblBacteria BAB96698 http://www.ensemblgenomes.org/id/BAB96698 EnsemblBacteria BAB96698 http://www.ensemblgenomes.org/id/BAB96698 EnsemblBacteria BAB96698 http://www.ensemblgenomes.org/id/BAB96698 EnsemblBacteria b0123 http://www.ensemblgenomes.org/id/b0123 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0005507 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005507 GO_function GO:0016722 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016722 GO_function GO:0052716 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052716 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 2.60.40.420 http://www.cathdb.info/version/latest/superfamily/2.60.40.420 GeneID 947736 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947736 HOGENOM HOG000096435 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000096435&db=HOGENOM6 InParanoid P36649 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P36649 IntAct P36649 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P36649* InterPro IPR001117 http://www.ebi.ac.uk/interpro/entry/IPR001117 InterPro IPR002355 http://www.ebi.ac.uk/interpro/entry/IPR002355 InterPro IPR006311 http://www.ebi.ac.uk/interpro/entry/IPR006311 InterPro IPR008972 http://www.ebi.ac.uk/interpro/entry/IPR008972 InterPro IPR011706 http://www.ebi.ac.uk/interpro/entry/IPR011706 InterPro IPR011707 http://www.ebi.ac.uk/interpro/entry/IPR011707 KEGG_Gene ecj:JW0119 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0119 KEGG_Gene eco:b0123 http://www.genome.jp/dbget-bin/www_bget?eco:b0123 KEGG_Orthology KO:K14588 http://www.genome.jp/dbget-bin/www_bget?KO:K14588 OMA FWQFGAG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FWQFGAG PDB 1KV7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1KV7 PDB 1N68 http://www.ebi.ac.uk/pdbe-srv/view/entry/1N68 PDB 1PF3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1PF3 PDB 2FQD http://www.ebi.ac.uk/pdbe-srv/view/entry/2FQD PDB 2FQE http://www.ebi.ac.uk/pdbe-srv/view/entry/2FQE PDB 2FQF http://www.ebi.ac.uk/pdbe-srv/view/entry/2FQF PDB 2FQG http://www.ebi.ac.uk/pdbe-srv/view/entry/2FQG PDB 2YXV http://www.ebi.ac.uk/pdbe-srv/view/entry/2YXV PDB 2YXW http://www.ebi.ac.uk/pdbe-srv/view/entry/2YXW PDB 3NSC http://www.ebi.ac.uk/pdbe-srv/view/entry/3NSC PDB 3NSD http://www.ebi.ac.uk/pdbe-srv/view/entry/3NSD PDB 3NSF http://www.ebi.ac.uk/pdbe-srv/view/entry/3NSF PDB 3NSY http://www.ebi.ac.uk/pdbe-srv/view/entry/3NSY PDB 3NT0 http://www.ebi.ac.uk/pdbe-srv/view/entry/3NT0 PDB 3OD3 http://www.ebi.ac.uk/pdbe-srv/view/entry/3OD3 PDB 3PAU http://www.ebi.ac.uk/pdbe-srv/view/entry/3PAU PDB 3PAV http://www.ebi.ac.uk/pdbe-srv/view/entry/3PAV PDB 3QQX http://www.ebi.ac.uk/pdbe-srv/view/entry/3QQX PDB 3UAA http://www.ebi.ac.uk/pdbe-srv/view/entry/3UAA PDB 3UAB http://www.ebi.ac.uk/pdbe-srv/view/entry/3UAB PDB 3UAC http://www.ebi.ac.uk/pdbe-srv/view/entry/3UAC PDB 3UAD http://www.ebi.ac.uk/pdbe-srv/view/entry/3UAD PDB 3UAE http://www.ebi.ac.uk/pdbe-srv/view/entry/3UAE PDB 4E9Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4E9Q PDB 4E9R http://www.ebi.ac.uk/pdbe-srv/view/entry/4E9R PDB 4E9S http://www.ebi.ac.uk/pdbe-srv/view/entry/4E9S PDB 4E9T http://www.ebi.ac.uk/pdbe-srv/view/entry/4E9T PDB 4EF3 http://www.ebi.ac.uk/pdbe-srv/view/entry/4EF3 PDB 4HAK http://www.ebi.ac.uk/pdbe-srv/view/entry/4HAK PDB 4HAL http://www.ebi.ac.uk/pdbe-srv/view/entry/4HAL PDB 4NER http://www.ebi.ac.uk/pdbe-srv/view/entry/4NER PDB 5B7E http://www.ebi.ac.uk/pdbe-srv/view/entry/5B7E PDB 5B7F http://www.ebi.ac.uk/pdbe-srv/view/entry/5B7F PDB 5B7M http://www.ebi.ac.uk/pdbe-srv/view/entry/5B7M PDBsum 1KV7 http://www.ebi.ac.uk/pdbsum/1KV7 PDBsum 1N68 http://www.ebi.ac.uk/pdbsum/1N68 PDBsum 1PF3 http://www.ebi.ac.uk/pdbsum/1PF3 PDBsum 2FQD http://www.ebi.ac.uk/pdbsum/2FQD PDBsum 2FQE http://www.ebi.ac.uk/pdbsum/2FQE PDBsum 2FQF http://www.ebi.ac.uk/pdbsum/2FQF PDBsum 2FQG http://www.ebi.ac.uk/pdbsum/2FQG PDBsum 2YXV http://www.ebi.ac.uk/pdbsum/2YXV PDBsum 2YXW http://www.ebi.ac.uk/pdbsum/2YXW PDBsum 3NSC http://www.ebi.ac.uk/pdbsum/3NSC PDBsum 3NSD http://www.ebi.ac.uk/pdbsum/3NSD PDBsum 3NSF http://www.ebi.ac.uk/pdbsum/3NSF PDBsum 3NSY http://www.ebi.ac.uk/pdbsum/3NSY PDBsum 3NT0 http://www.ebi.ac.uk/pdbsum/3NT0 PDBsum 3OD3 http://www.ebi.ac.uk/pdbsum/3OD3 PDBsum 3PAU http://www.ebi.ac.uk/pdbsum/3PAU PDBsum 3PAV http://www.ebi.ac.uk/pdbsum/3PAV PDBsum 3QQX http://www.ebi.ac.uk/pdbsum/3QQX PDBsum 3UAA http://www.ebi.ac.uk/pdbsum/3UAA PDBsum 3UAB http://www.ebi.ac.uk/pdbsum/3UAB PDBsum 3UAC http://www.ebi.ac.uk/pdbsum/3UAC PDBsum 3UAD http://www.ebi.ac.uk/pdbsum/3UAD PDBsum 3UAE http://www.ebi.ac.uk/pdbsum/3UAE PDBsum 4E9Q http://www.ebi.ac.uk/pdbsum/4E9Q PDBsum 4E9R http://www.ebi.ac.uk/pdbsum/4E9R PDBsum 4E9S http://www.ebi.ac.uk/pdbsum/4E9S PDBsum 4E9T http://www.ebi.ac.uk/pdbsum/4E9T PDBsum 4EF3 http://www.ebi.ac.uk/pdbsum/4EF3 PDBsum 4HAK http://www.ebi.ac.uk/pdbsum/4HAK PDBsum 4HAL http://www.ebi.ac.uk/pdbsum/4HAL PDBsum 4NER http://www.ebi.ac.uk/pdbsum/4NER PDBsum 5B7E http://www.ebi.ac.uk/pdbsum/5B7E PDBsum 5B7F http://www.ebi.ac.uk/pdbsum/5B7F PDBsum 5B7M http://www.ebi.ac.uk/pdbsum/5B7M PROSITE PS00080 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00080 PROSITE PS51318 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51318 PSORT swissprot:CUEO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CUEO_ECOLI PSORT-B swissprot:CUEO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CUEO_ECOLI PSORT2 swissprot:CUEO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CUEO_ECOLI Pfam PF00394 http://pfam.xfam.org/family/PF00394 Pfam PF07731 http://pfam.xfam.org/family/PF07731 Pfam PF07732 http://pfam.xfam.org/family/PF07732 Phobius swissprot:CUEO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CUEO_ECOLI PhylomeDB P36649 http://phylomedb.org/?seqid=P36649 ProteinModelPortal P36649 http://www.proteinmodelportal.org/query/uniprot/P36649 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 10915804 http://www.ncbi.nlm.nih.gov/pubmed/10915804 PubMed 11222619 http://www.ncbi.nlm.nih.gov/pubmed/11222619 PubMed 11399769 http://www.ncbi.nlm.nih.gov/pubmed/11399769 PubMed 11466290 http://www.ncbi.nlm.nih.gov/pubmed/11466290 PubMed 11527384 http://www.ncbi.nlm.nih.gov/pubmed/11527384 PubMed 11867755 http://www.ncbi.nlm.nih.gov/pubmed/11867755 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17218314 http://www.ncbi.nlm.nih.gov/pubmed/17218314 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_414665 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414665 RefSeq WP_001189647 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001189647 SMR P36649 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P36649 STRING 511145.b0123 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0123&targetmode=cogs STRING COG2132 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2132&targetmode=cogs SUPFAM SSF49503 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49503 TCDB 1.B.76.1 http://www.tcdb.org/search/result.php?tc=1.B.76.1 UniProtKB CUEO_ECOLI http://www.uniprot.org/uniprot/CUEO_ECOLI UniProtKB-AC P36649 http://www.uniprot.org/uniprot/P36649 charge swissprot:CUEO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CUEO_ECOLI eggNOG COG2132 http://eggnogapi.embl.de/nog_data/html/tree/COG2132 eggNOG ENOG4105E3B http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E3B epestfind swissprot:CUEO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CUEO_ECOLI garnier swissprot:CUEO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CUEO_ECOLI helixturnhelix swissprot:CUEO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CUEO_ECOLI hmoment swissprot:CUEO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CUEO_ECOLI iep swissprot:CUEO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CUEO_ECOLI inforesidue swissprot:CUEO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CUEO_ECOLI octanol swissprot:CUEO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CUEO_ECOLI pepcoil swissprot:CUEO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CUEO_ECOLI pepdigest swissprot:CUEO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CUEO_ECOLI pepinfo swissprot:CUEO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CUEO_ECOLI pepnet swissprot:CUEO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CUEO_ECOLI pepstats swissprot:CUEO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CUEO_ECOLI pepwheel swissprot:CUEO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CUEO_ECOLI pepwindow swissprot:CUEO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CUEO_ECOLI sigcleave swissprot:CUEO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CUEO_ECOLI ## Database ID URL or Descriptions # BRENDA 3.6.3.20 2026 # BioGrid 4263421 118 # CDD cd06261 TM_PBP2 # EcoGene EG11046 ugpA # FUNCTION UGPA_ECOLI Part of the binding-protein-dependent transport system for sn-glycerol-3-phosphate; probably responsible for the translocation of the substrate across the membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0055052 ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing; IDA:EcoCyc. # GO_function GO:0001406 glycerophosphodiester transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0015169 glycerol-3-phosphate transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0001407 glycerophosphodiester transport; IDA:EcoCyc. # GO_process GO:0015794 glycerol-3-phosphate transport; IMP:EcoCyc. # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # Gene3D 1.10.3720.10 -; 1. # InterPro IPR000515 MetI-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00198 Putative sn-glycerol-phosphate transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism UGPA_ECOLI Escherichia coli (strain K12) # PATRIC 32122344 VBIEscCol129921_3549 # PIR S03781 MMECUA # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UGPA_ECOLI sn-glycerol-3-phosphate transport system permease protein UgpA # RefSeq NP_417909 NC_000913.3 # RefSeq WP_000099289 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. UgpAE subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION UGPA_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT The complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute- binding protein (UgpB). {ECO 0000305}. # SUPFAM SSF161098 SSF161098 # TCDB 3.A.1.1 the atp-binding cassette (abc) superfamily # eggNOG COG1175 LUCA # eggNOG ENOG4105E4X Bacteria BLAST swissprot:UGPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UGPA_ECOLI BioCyc ECOL316407:JW3417-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3417-MONOMER BioCyc EcoCyc:UGPA-MONOMER http://biocyc.org/getid?id=EcoCyc:UGPA-MONOMER BioCyc MetaCyc:UGPA-MONOMER http://biocyc.org/getid?id=MetaCyc:UGPA-MONOMER COG COG1175 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1175 DIP DIP-11077N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11077N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1111/j.1365-2958.1988.tb00088.x http://dx.doi.org/10.1111/j.1365-2958.1988.tb00088.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X13141 http://www.ebi.ac.uk/ena/data/view/X13141 EchoBASE EB1039 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1039 EcoGene EG11046 http://www.ecogene.org/geneInfo.php?eg_id=EG11046 EnsemblBacteria AAC76477 http://www.ensemblgenomes.org/id/AAC76477 EnsemblBacteria AAC76477 http://www.ensemblgenomes.org/id/AAC76477 EnsemblBacteria BAE77841 http://www.ensemblgenomes.org/id/BAE77841 EnsemblBacteria BAE77841 http://www.ensemblgenomes.org/id/BAE77841 EnsemblBacteria BAE77841 http://www.ensemblgenomes.org/id/BAE77841 EnsemblBacteria b3452 http://www.ensemblgenomes.org/id/b3452 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0055052 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055052 GO_function GO:0001406 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001406 GO_function GO:0015169 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015169 GO_process GO:0001407 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001407 GO_process GO:0015794 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015794 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 947957 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947957 HOGENOM HOG000220406 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220406&db=HOGENOM6 InParanoid P10905 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P10905 IntAct P10905 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P10905* InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3417 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3417 KEGG_Gene eco:b3452 http://www.genome.jp/dbget-bin/www_bget?eco:b3452 KEGG_Orthology KO:K05814 http://www.genome.jp/dbget-bin/www_bget?KO:K05814 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA FFYTDAF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FFYTDAF PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:UGPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UGPA_ECOLI PSORT-B swissprot:UGPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UGPA_ECOLI PSORT2 swissprot:UGPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UGPA_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Phobius swissprot:UGPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UGPA_ECOLI PhylomeDB P10905 http://phylomedb.org/?seqid=P10905 ProteinModelPortal P10905 http://www.proteinmodelportal.org/query/uniprot/P10905 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3062310 http://www.ncbi.nlm.nih.gov/pubmed/3062310 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417909 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417909 RefSeq WP_000099289 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000099289 SMR P10905 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P10905 STRING 511145.b3452 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3452&targetmode=cogs STRING COG1175 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1175&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.1 http://www.tcdb.org/search/result.php?tc=3.A.1.1 UniProtKB UGPA_ECOLI http://www.uniprot.org/uniprot/UGPA_ECOLI UniProtKB-AC P10905 http://www.uniprot.org/uniprot/P10905 charge swissprot:UGPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UGPA_ECOLI eggNOG COG1175 http://eggnogapi.embl.de/nog_data/html/tree/COG1175 eggNOG ENOG4105E4X http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E4X epestfind swissprot:UGPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UGPA_ECOLI garnier swissprot:UGPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UGPA_ECOLI helixturnhelix swissprot:UGPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UGPA_ECOLI hmoment swissprot:UGPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UGPA_ECOLI iep swissprot:UGPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UGPA_ECOLI inforesidue swissprot:UGPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UGPA_ECOLI octanol swissprot:UGPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UGPA_ECOLI pepcoil swissprot:UGPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UGPA_ECOLI pepdigest swissprot:UGPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UGPA_ECOLI pepinfo swissprot:UGPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UGPA_ECOLI pepnet swissprot:UGPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UGPA_ECOLI pepstats swissprot:UGPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UGPA_ECOLI pepwheel swissprot:UGPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UGPA_ECOLI pepwindow swissprot:UGPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UGPA_ECOLI sigcleave swissprot:UGPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UGPA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261334 5 # EcoGene EG14184 eutJ # GO_process GO:0046336 ethanolamine catabolic process; IEA:UniProtKB-UniPathway. # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # IntAct P77277 5 # InterPro IPR013366 EutJ # Organism EUTJ_ECOLI Escherichia coli (strain K12) # PATHWAY EUTJ_ECOLI Amine and polyamine degradation; ethanolamine degradation. # PATRIC 32120291 VBIEscCol129921_2548 # PIR E65020 E65020 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EUTJ_ECOLI Ethanolamine utilization protein EutJ # RefSeq NP_416949 NC_000913.3 # RefSeq WP_000929729 NZ_LN832404.1 # TIGRFAMs TIGR02529 EutJ # eggNOG COG4820 LUCA # eggNOG ENOG4107RWI Bacteria BLAST swissprot:EUTJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EUTJ_ECOLI BioCyc ECOL316407:JW2438-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2438-MONOMER BioCyc EcoCyc:G7284-MONOMER http://biocyc.org/getid?id=EcoCyc:G7284-MONOMER COG COG4820 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4820 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3936 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3936 EcoGene EG14184 http://www.ecogene.org/geneInfo.php?eg_id=EG14184 EnsemblBacteria AAC75507 http://www.ensemblgenomes.org/id/AAC75507 EnsemblBacteria AAC75507 http://www.ensemblgenomes.org/id/AAC75507 EnsemblBacteria BAA16332 http://www.ensemblgenomes.org/id/BAA16332 EnsemblBacteria BAA16332 http://www.ensemblgenomes.org/id/BAA16332 EnsemblBacteria BAA16332 http://www.ensemblgenomes.org/id/BAA16332 EnsemblBacteria b2454 http://www.ensemblgenomes.org/id/b2454 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0046336 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046336 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 947588 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947588 HOGENOM HOG000287728 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000287728&db=HOGENOM6 InParanoid P77277 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77277 IntAct P77277 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77277* InterPro IPR013366 http://www.ebi.ac.uk/interpro/entry/IPR013366 KEGG_Gene ecj:JW2438 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2438 KEGG_Gene eco:b2454 http://www.genome.jp/dbget-bin/www_bget?eco:b2454 KEGG_Orthology KO:K04024 http://www.genome.jp/dbget-bin/www_bget?KO:K04024 OMA MAHDEQR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MAHDEQR PSORT swissprot:EUTJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EUTJ_ECOLI PSORT-B swissprot:EUTJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EUTJ_ECOLI PSORT2 swissprot:EUTJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EUTJ_ECOLI Phobius swissprot:EUTJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EUTJ_ECOLI ProteinModelPortal P77277 http://www.proteinmodelportal.org/query/uniprot/P77277 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416949 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416949 RefSeq WP_000929729 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000929729 SMR P77277 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77277 STRING 511145.b2454 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2454&targetmode=cogs STRING COG4820 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4820&targetmode=cogs TIGRFAMs TIGR02529 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02529 UniProtKB EUTJ_ECOLI http://www.uniprot.org/uniprot/EUTJ_ECOLI UniProtKB-AC P77277 http://www.uniprot.org/uniprot/P77277 charge swissprot:EUTJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EUTJ_ECOLI eggNOG COG4820 http://eggnogapi.embl.de/nog_data/html/tree/COG4820 eggNOG ENOG4107RWI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107RWI epestfind swissprot:EUTJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EUTJ_ECOLI garnier swissprot:EUTJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EUTJ_ECOLI helixturnhelix swissprot:EUTJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EUTJ_ECOLI hmoment swissprot:EUTJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EUTJ_ECOLI iep swissprot:EUTJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EUTJ_ECOLI inforesidue swissprot:EUTJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EUTJ_ECOLI octanol swissprot:EUTJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EUTJ_ECOLI pepcoil swissprot:EUTJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EUTJ_ECOLI pepdigest swissprot:EUTJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EUTJ_ECOLI pepinfo swissprot:EUTJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EUTJ_ECOLI pepnet swissprot:EUTJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EUTJ_ECOLI pepstats swissprot:EUTJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EUTJ_ECOLI pepwheel swissprot:EUTJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EUTJ_ECOLI pepwindow swissprot:EUTJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EUTJ_ECOLI sigcleave swissprot:EUTJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EUTJ_ECOLI ## Database ID URL or Descriptions # AltName PDXA_ECOLI 4-(phosphohydroxy)-L-threonine dehydrogenase # BIOPHYSICOCHEMICAL PROPERTIES PDXA_ECOLI Kinetic parameters KM=85 uM for 4-(phosphohydroxy)-L-threonine (at 0.1 M Tris-HCl and pH 7.5) {ECO 0000269|Ref.5}; KM=113 uM for 4-(phosphohydroxy)-L-threonine (at 0.1 M phosphate buffer and pH 7.5) {ECO 0000269|Ref.5}; Vmax=2.8 umol/min/mg enzyme with 4-(phosphohydroxy)-L-threonine as substrate (at 0.1 M Tris-HCl and pH 7.5) {ECO 0000269|Ref.5}; Vmax=0.66 umol/min/mg enzyme with 4-(phosphohydroxy)-L-threonine as substrate (at 0.1 M phosphate buffer and pH 7.5) {ECO 0000269|Ref.5}; # BRENDA 1.1.1.262 2026 # BioGrid 4261013 5 # CATALYTIC ACTIVITY 4-phosphonooxy-L-threonine + NAD(+) = 3-amino- 2-oxopropyl phosphate + CO(2) + NADH. {ECO:0000269|PubMed 15026039}. # COFACTOR PDXA_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 12896974, ECO 0000269|Ref.5}; Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 12896974, ECO 0000269|Ref.5}; Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000269|PubMed 12896974, ECO 0000269|Ref.5}; Note=Binds 1 divalent metal cation per subunit. Can use ions such as Zn(2+), Mg(2+) or Co(2+). {ECO 0000269|PubMed 12896974, ECO 0000269|Ref.5}; # EcoGene EG10691 pdxA # FUNCTION PDXA_ECOLI Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). {ECO 0000269|PubMed 15026039, ECO 0000269|Ref.5}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_function GO:0050570 4-hydroxythreonine-4-phosphate dehydrogenase activity; IDA:EcoCyc. # GO_function GO:0050897 cobalt ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0051287 NAD binding; IDA:EcoCyc. # GO_process GO:0008615 pyridoxine biosynthetic process; IMP:EcoCyc. # GO_process GO:0042823 pyridoxal phosphate biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.718.10 -; 1. # HAMAP MF_00536 PdxA # INTERACTION PDXA_ECOLI Self; NbExp=3; IntAct=EBI-1112869, EBI-1112869; # IntAct P19624 5 # InterPro IPR005255 PdxA # InterPro IPR024084 IsoPropMal-DH-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00750 Vitamin B6 metabolism # MISCELLANEOUS According to PubMed 15026039, PdxA may catalyze both oxidation and decarboxylation reactions that directly lead to AHAP. # MISCELLANEOUS PDXA_ECOLI The active site is located at the dimer interface. # Organism PDXA_ECOLI Escherichia coli (strain K12) # PATHWAY Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4- phosphate step 4/5. # PATRIC 32115203 VBIEscCol129921_0053 # PDB 1PS6 X-ray; 2.25 A; A/B=2-329 # PDB 1PS7 X-ray; 2.47 A; A/B/C/D=1-329 # PDB 1PTM X-ray; 1.96 A; A/B=1-329 # PIR JV0026 BVECXA # Pfam PF04166 PdxA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PDXA_ECOLI 4-hydroxythreonine-4-phosphate dehydrogenase # RefSeq NP_414594 NC_000913.3 # RefSeq WP_000241277 NZ_LN832404.1 # SIMILARITY Belongs to the PdxA family. {ECO 0000305}. # SUBCELLULAR LOCATION PDXA_ECOLI Cytoplasm {ECO 0000250}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 12896974}. # TIGRFAMs TIGR00557 pdxA # UniPathway UPA00244 UER00312 # eggNOG COG1995 LUCA # eggNOG ENOG4105CEZ Bacteria BLAST swissprot:PDXA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PDXA_ECOLI BioCyc ECOL316407:JW0051-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0051-MONOMER BioCyc EcoCyc:PDXA-MONOMER http://biocyc.org/getid?id=EcoCyc:PDXA-MONOMER BioCyc MetaCyc:PDXA-MONOMER http://biocyc.org/getid?id=MetaCyc:PDXA-MONOMER COG COG1995 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1995 DIP DIP-10448N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10448N DOI 10.1016/j.bmcl.2004.01.065 http://dx.doi.org/10.1016/j.bmcl.2004.01.065 DOI 10.1021/ja9742085 http://dx.doi.org/10.1021/ja9742085 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M306344200 http://dx.doi.org/10.1074/jbc.M306344200 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.262 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.262 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M68521 http://www.ebi.ac.uk/ena/data/view/M68521 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.1.1.262 http://enzyme.expasy.org/EC/1.1.1.262 EchoBASE EB0685 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0685 EcoGene EG10691 http://www.ecogene.org/geneInfo.php?eg_id=EG10691 EnsemblBacteria AAC73163 http://www.ensemblgenomes.org/id/AAC73163 EnsemblBacteria AAC73163 http://www.ensemblgenomes.org/id/AAC73163 EnsemblBacteria BAB96619 http://www.ensemblgenomes.org/id/BAB96619 EnsemblBacteria BAB96619 http://www.ensemblgenomes.org/id/BAB96619 EnsemblBacteria BAB96619 http://www.ensemblgenomes.org/id/BAB96619 EnsemblBacteria b0052 http://www.ensemblgenomes.org/id/b0052 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0050570 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050570 GO_function GO:0050897 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050897 GO_function GO:0051287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051287 GO_process GO:0008615 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008615 GO_process GO:0042823 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042823 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.718.10 http://www.cathdb.info/version/latest/superfamily/3.40.718.10 GeneID 944919 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944919 HAMAP MF_00536 http://hamap.expasy.org/unirule/MF_00536 HOGENOM HOG000221592 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000221592&db=HOGENOM6 InParanoid P19624 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P19624 IntAct P19624 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P19624* IntEnz 1.1.1.262 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.262 InterPro IPR005255 http://www.ebi.ac.uk/interpro/entry/IPR005255 InterPro IPR024084 http://www.ebi.ac.uk/interpro/entry/IPR024084 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0051 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0051 KEGG_Gene eco:b0052 http://www.genome.jp/dbget-bin/www_bget?eco:b0052 KEGG_Orthology KO:K00097 http://www.genome.jp/dbget-bin/www_bget?KO:K00097 KEGG_Pathway ko00750 http://www.genome.jp/kegg-bin/show_pathway?ko00750 KEGG_Reaction rn:R05681 http://www.genome.jp/dbget-bin/www_bget?rn:R05681 KEGG_Reaction rn:R05837 http://www.genome.jp/dbget-bin/www_bget?rn:R05837 KEGG_Reaction rn:R07406 http://www.genome.jp/dbget-bin/www_bget?rn:R07406 OMA YVWDTPL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YVWDTPL PDB 1PS6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1PS6 PDB 1PS7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1PS7 PDB 1PTM http://www.ebi.ac.uk/pdbe-srv/view/entry/1PTM PDBsum 1PS6 http://www.ebi.ac.uk/pdbsum/1PS6 PDBsum 1PS7 http://www.ebi.ac.uk/pdbsum/1PS7 PDBsum 1PTM http://www.ebi.ac.uk/pdbsum/1PTM PSORT swissprot:PDXA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PDXA_ECOLI PSORT-B swissprot:PDXA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PDXA_ECOLI PSORT2 swissprot:PDXA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PDXA_ECOLI Pfam PF04166 http://pfam.xfam.org/family/PF04166 Phobius swissprot:PDXA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PDXA_ECOLI PhylomeDB P19624 http://phylomedb.org/?seqid=P19624 ProteinModelPortal P19624 http://www.proteinmodelportal.org/query/uniprot/P19624 PubMed 12896974 http://www.ncbi.nlm.nih.gov/pubmed/12896974 PubMed 15026039 http://www.ncbi.nlm.nih.gov/pubmed/15026039 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2670894 http://www.ncbi.nlm.nih.gov/pubmed/2670894 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414594 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414594 RefSeq WP_000241277 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000241277 SMR P19624 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P19624 STRING 511145.b0052 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0052&targetmode=cogs STRING COG1995 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1995&targetmode=cogs TIGRFAMs TIGR00557 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00557 UniProtKB PDXA_ECOLI http://www.uniprot.org/uniprot/PDXA_ECOLI UniProtKB-AC P19624 http://www.uniprot.org/uniprot/P19624 charge swissprot:PDXA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PDXA_ECOLI eggNOG COG1995 http://eggnogapi.embl.de/nog_data/html/tree/COG1995 eggNOG ENOG4105CEZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CEZ epestfind swissprot:PDXA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PDXA_ECOLI garnier swissprot:PDXA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PDXA_ECOLI helixturnhelix swissprot:PDXA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PDXA_ECOLI hmoment swissprot:PDXA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PDXA_ECOLI iep swissprot:PDXA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PDXA_ECOLI inforesidue swissprot:PDXA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PDXA_ECOLI octanol swissprot:PDXA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PDXA_ECOLI pepcoil swissprot:PDXA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PDXA_ECOLI pepdigest swissprot:PDXA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PDXA_ECOLI pepinfo swissprot:PDXA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PDXA_ECOLI pepnet swissprot:PDXA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PDXA_ECOLI pepstats swissprot:PDXA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PDXA_ECOLI pepwheel swissprot:PDXA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PDXA_ECOLI pepwindow swissprot:PDXA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PDXA_ECOLI sigcleave swissprot:PDXA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PDXA_ECOLI ## Database ID URL or Descriptions # AltName CYAA_ECOLI ATP pyrophosphate-lyase # AltName CYAA_ECOLI Adenylyl cyclase # BRENDA 4.6.1 2026 # BioGrid 4262610 6 # CATALYTIC ACTIVITY CYAA_ECOLI ATP = 3',5'-cyclic AMP + diphosphate. # DISRUPTION PHENOTYPE Not essential, eliminates the NaCl sensitivity of an rnlA deletion mutant. {ECO:0000269|PubMed 19019153}. # ENZYME REGULATION CYAA_ECOLI The regulatory domain is involved in the regulation of cyclase activity by the carbon source. Activated by the PTS system, glucose-specific IIA component (CRR). # EcoGene EG10170 cyaA # FUNCTION CYAA_ECOLI Catalyzes the formation of the second messenger cAMP from ATP. Its transcript is probably degraded by endoribonuclease LS (rnlA), decreasing cAMP levels and the negative regulator Crp- cAMP, which then induces its own transcription again. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0004016 adenylate cyclase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0006171 cAMP biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # INDUCTION CYAA_ECOLI Repressed by the Crp-cAMP complex. Expression increases during growth, decreasing again in stationary phase; more strongly induced in an rnlA deletion mutant, levels remain high even in stationary phase (at protein level). {ECO 0000269|PubMed 19019153, ECO 0000269|PubMed 2982847}. # INTERACTION CYAA_ECOLI P15038 helD; NbExp=3; IntAct=EBI-1116685, EBI-551473; # IntAct P00936 23 # InterPro IPR000274 Adenylate_cyclase_1 # InterPro IPR024685 Adenylate_cyclase_1_N # InterPro IPR024686 Adenylate_cyclase_1_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko05111 Vibrio cholerae pathogenic cycle # Organism CYAA_ECOLI Escherichia coli (strain K12) # PATRIC 32123111 VBIEscCol129921_3921 # PIR G65184 OYEC # PIRSF PIRSF001444 Adenylate_cycl # PROSITE PS01092 ADENYLATE_CYCLASE_1_1 # PROSITE PS01093 ADENYLATE_CYCLASE_1_2 # Pfam PF01295 Adenylate_cycl # Pfam PF12633 Adenyl_cycl_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CYAA_ECOLI Adenylate cyclase # RefSeq NP_418250 NC_000913.3 # RefSeq WP_000281668 NZ_LN832404.1 # SIMILARITY Belongs to the adenylyl cyclase class-1 family. {ECO 0000305}. # SUBCELLULAR LOCATION CYAA_ECOLI Cytoplasm. # WEB RESOURCE CYAA_ECOLI Name=Escherichia coli adenylate cyclase homepage; URL="http //minst.org/ecoli_cyclase.htm"; # eggNOG COG3072 LUCA # eggNOG ENOG4107T0K Bacteria BLAST swissprot:CYAA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CYAA_ECOLI BioCyc ECOL316407:JW3778-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3778-MONOMER BioCyc EcoCyc:ADENYLATECYC-MONOMER http://biocyc.org/getid?id=EcoCyc:ADENYLATECYC-MONOMER BioCyc MetaCyc:ADENYLATECYC-MONOMER http://biocyc.org/getid?id=MetaCyc:ADENYLATECYC-MONOMER COG COG3072 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3072 DOI 10.1016/0300-9084(96)82192-4 http://dx.doi.org/10.1016/0300-9084(96)82192-4 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/11.11.3451 http://dx.doi.org/10.1093/nar/11.11.3451 DOI 10.1093/nar/12.24.9427 http://dx.doi.org/10.1093/nar/12.24.9427 DOI 10.1111/j.1365-2958.2008.06504.x http://dx.doi.org/10.1111/j.1365-2958.2008.06504.x DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.6.1.1 http://www.genome.jp/dbget-bin/www_bget?EC:4.6.1.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X01653 http://www.ebi.ac.uk/ena/data/view/X01653 EMBL X66782 http://www.ebi.ac.uk/ena/data/view/X66782 ENZYME 4.6.1.1 http://enzyme.expasy.org/EC/4.6.1.1 EchoBASE EB0168 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0168 EcoGene EG10170 http://www.ecogene.org/geneInfo.php?eg_id=EG10170 EnsemblBacteria AAC76809 http://www.ensemblgenomes.org/id/AAC76809 EnsemblBacteria AAC76809 http://www.ensemblgenomes.org/id/AAC76809 EnsemblBacteria BAE77495 http://www.ensemblgenomes.org/id/BAE77495 EnsemblBacteria BAE77495 http://www.ensemblgenomes.org/id/BAE77495 EnsemblBacteria BAE77495 http://www.ensemblgenomes.org/id/BAE77495 EnsemblBacteria b3806 http://www.ensemblgenomes.org/id/b3806 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004016 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004016 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006171 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006171 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 947755 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947755 HOGENOM HOG000270910 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000270910&db=HOGENOM6 InParanoid P00936 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00936 IntAct P00936 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00936* IntEnz 4.6.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.6.1.1 InterPro IPR000274 http://www.ebi.ac.uk/interpro/entry/IPR000274 InterPro IPR024685 http://www.ebi.ac.uk/interpro/entry/IPR024685 InterPro IPR024686 http://www.ebi.ac.uk/interpro/entry/IPR024686 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3778 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3778 KEGG_Gene eco:b3806 http://www.genome.jp/dbget-bin/www_bget?eco:b3806 KEGG_Orthology KO:K05851 http://www.genome.jp/dbget-bin/www_bget?KO:K05851 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko05111 http://www.genome.jp/kegg-bin/show_pathway?ko05111 KEGG_Reaction rn:R00089 http://www.genome.jp/dbget-bin/www_bget?rn:R00089 KEGG_Reaction rn:R00434 http://www.genome.jp/dbget-bin/www_bget?rn:R00434 OMA DYVMSLY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DYVMSLY PROSITE PS01092 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01092 PROSITE PS01093 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01093 PSORT swissprot:CYAA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CYAA_ECOLI PSORT-B swissprot:CYAA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CYAA_ECOLI PSORT2 swissprot:CYAA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CYAA_ECOLI Pfam PF01295 http://pfam.xfam.org/family/PF01295 Pfam PF12633 http://pfam.xfam.org/family/PF12633 Phobius swissprot:CYAA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CYAA_ECOLI ProteinModelPortal P00936 http://www.proteinmodelportal.org/query/uniprot/P00936 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19019153 http://www.ncbi.nlm.nih.gov/pubmed/19019153 PubMed 2982847 http://www.ncbi.nlm.nih.gov/pubmed/2982847 PubMed 6344011 http://www.ncbi.nlm.nih.gov/pubmed/6344011 PubMed 6357786 http://www.ncbi.nlm.nih.gov/pubmed/6357786 PubMed 6393056 http://www.ncbi.nlm.nih.gov/pubmed/6393056 PubMed 8418825 http://www.ncbi.nlm.nih.gov/pubmed/8418825 PubMed 8874804 http://www.ncbi.nlm.nih.gov/pubmed/8874804 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418250 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418250 RefSeq WP_000281668 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000281668 STRING 511145.b3806 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3806&targetmode=cogs STRING COG3072 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3072&targetmode=cogs UniProtKB CYAA_ECOLI http://www.uniprot.org/uniprot/CYAA_ECOLI UniProtKB-AC P00936 http://www.uniprot.org/uniprot/P00936 charge swissprot:CYAA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CYAA_ECOLI eggNOG COG3072 http://eggnogapi.embl.de/nog_data/html/tree/COG3072 eggNOG ENOG4107T0K http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107T0K epestfind swissprot:CYAA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CYAA_ECOLI garnier swissprot:CYAA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CYAA_ECOLI helixturnhelix swissprot:CYAA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CYAA_ECOLI hmoment swissprot:CYAA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CYAA_ECOLI iep swissprot:CYAA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CYAA_ECOLI inforesidue swissprot:CYAA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CYAA_ECOLI octanol swissprot:CYAA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CYAA_ECOLI pepcoil swissprot:CYAA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CYAA_ECOLI pepdigest swissprot:CYAA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CYAA_ECOLI pepinfo swissprot:CYAA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CYAA_ECOLI pepnet swissprot:CYAA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CYAA_ECOLI pepstats swissprot:CYAA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CYAA_ECOLI pepwheel swissprot:CYAA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CYAA_ECOLI pepwindow swissprot:CYAA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CYAA_ECOLI sigcleave swissprot:CYAA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CYAA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261403 319 # DISRUPTION PHENOTYPE Growth continues, but export of its substrates is blocked. Expression of chaperones DnaK, GroEL/ES, ClpB, and HslU increases. {ECO:0000269|PubMed 16352602}. # EcoGene EG10937 secB # FUNCTION SECB_ECOLI One of the proteins required for the normal export of some preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. Its substrates include AmpC, DegP, FhuA, FkpA, GBP, LamB, MalE (MBP), OmpA, OmpF, OmpT, OmpX, OppA, PhoE, TolB, TolC, YbgF, YcgK, YgiW and YncE. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0051082 unfolded protein binding; IDA:EcoCyc. # GO_process GO:0006457 protein folding; IEA:UniProtKB-HAMAP. # GO_process GO:0006605 protein targeting; IMP:EcoliWiki. # GO_process GO:0008104 protein localization; IMP:EcoCyc. # GO_process GO:0015031 protein transport; IMP:EcoliWiki. # GO_process GO:0043952 protein transport by the Sec complex; IMP:EcoliWiki. # GO_process GO:0051262 protein tetramerization; IEA:InterPro. # GO_process GO:0072321 chaperone-mediated protein transport; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0051082 unfolded protein binding # GOslim_process GO:0006457 protein folding # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0006605 protein targeting # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # GOslim_process GO:0055085 transmembrane transport # Gene3D 3.10.420.10 -; 1. # HAMAP MF_00821 SecB # INTERACTION SECB_ECOLI P10408 secA; NbExp=4; IntAct=EBI-555877, EBI-543213; # IntAct P0AG86 14 # InterPro IPR003708 SecB # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02044 M00335 Sec (secretion) system # KEGG_Brite ko02044 Secretion system # KEGG_Brite ko03110 Chaperones and folding catalysts # KEGG_Pathway ko03060 Protein export # KEGG_Pathway ko03070 Bacterial secretion system # Organism SECB_ECOLI Escherichia coli (strain K12) # PATRIC 32122703 VBIEscCol129921_3728 # PDB 1QYN X-ray; 2.35 A; A/B/C/D=1-153 # PDB 5JTL NMR; -; A/B/C/D=1-155 # PDB 5JTM NMR; -; A/B/C/D=1-155 # PDB 5JTN NMR; -; A/B/C/D=1-155 # PDB 5JTO NMR; -; A/B/C/D=1-155 # PDB 5JTP NMR; -; A/B/C/D=1-155 # PDB 5JTQ NMR; -; A/B/C/D=1-155 # PDB 5JTR NMR; -; A/B/C/D=1-155 # PIR JS0126 VXECS # PRINTS PR01594 SECBCHAPRONE # Pfam PF02556 SecB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SECB_ECOLI Protein-export protein SecB # RefSeq NP_418066 NC_000913.3 # RefSeq WP_000003377 NZ_LN832404.1 # SIMILARITY Belongs to the SecB family. {ECO 0000305}. # SUBCELLULAR LOCATION SECB_ECOLI Cytoplasm. # SUBUNIT SECB_ECOLI Homotetramer, a dimer of dimers. One homotetramer interacts with 1 SecA dimer. # SUPFAM SSF54611 SSF54611 # TIGRFAMs TIGR00809 secB # eggNOG COG1952 LUCA # eggNOG ENOG4105IX2 Bacteria BLAST swissprot:SECB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SECB_ECOLI BioCyc ECOL316407:JW3584-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3584-MONOMER BioCyc EcoCyc:SECB http://biocyc.org/getid?id=EcoCyc:SECB COG COG1952 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1952 DIP DIP-47924N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47924N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0378-1119(89)90393-4 http://dx.doi.org/10.1016/0378-1119(89)90393-4 DOI 10.1016/j.jsb.2003.09.012 http://dx.doi.org/10.1016/j.jsb.2003.09.012 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nrmicro1771 http://dx.doi.org/10.1038/nrmicro1771 DOI 10.1074/jbc.M509929200 http://dx.doi.org/10.1074/jbc.M509929200 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M24489 http://www.ebi.ac.uk/ena/data/view/M24489 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0930 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0930 EcoGene EG10937 http://www.ecogene.org/geneInfo.php?eg_id=EG10937 EnsemblBacteria AAC76633 http://www.ensemblgenomes.org/id/AAC76633 EnsemblBacteria AAC76633 http://www.ensemblgenomes.org/id/AAC76633 EnsemblBacteria BAE77683 http://www.ensemblgenomes.org/id/BAE77683 EnsemblBacteria BAE77683 http://www.ensemblgenomes.org/id/BAE77683 EnsemblBacteria BAE77683 http://www.ensemblgenomes.org/id/BAE77683 EnsemblBacteria b3609 http://www.ensemblgenomes.org/id/b3609 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0051082 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051082 GO_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GO_process GO:0006605 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006605 GO_process GO:0008104 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008104 GO_process GO:0015031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031 GO_process GO:0043952 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043952 GO_process GO:0051262 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051262 GO_process GO:0072321 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072321 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0051082 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051082 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0006605 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006605 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 3.10.420.10 http://www.cathdb.info/version/latest/superfamily/3.10.420.10 GeneID 948123 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948123 HAMAP MF_00821 http://hamap.expasy.org/unirule/MF_00821 HOGENOM HOG000218192 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218192&db=HOGENOM6 InParanoid P0AG86 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AG86 IntAct P0AG86 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AG86* InterPro IPR003708 http://www.ebi.ac.uk/interpro/entry/IPR003708 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW3584 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3584 KEGG_Gene eco:b3609 http://www.genome.jp/dbget-bin/www_bget?eco:b3609 KEGG_Orthology KO:K03071 http://www.genome.jp/dbget-bin/www_bget?KO:K03071 KEGG_Pathway ko03060 http://www.genome.jp/kegg-bin/show_pathway?ko03060 KEGG_Pathway ko03070 http://www.genome.jp/kegg-bin/show_pathway?ko03070 MINT MINT-1248893 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1248893 OMA CPNVLFP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CPNVLFP PDB 1QYN http://www.ebi.ac.uk/pdbe-srv/view/entry/1QYN PDB 5JTL http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTL PDB 5JTM http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTM PDB 5JTN http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTN PDB 5JTO http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTO PDB 5JTP http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTP PDB 5JTQ http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTQ PDB 5JTR http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTR PDBsum 1QYN http://www.ebi.ac.uk/pdbsum/1QYN PDBsum 5JTL http://www.ebi.ac.uk/pdbsum/5JTL PDBsum 5JTM http://www.ebi.ac.uk/pdbsum/5JTM PDBsum 5JTN http://www.ebi.ac.uk/pdbsum/5JTN PDBsum 5JTO http://www.ebi.ac.uk/pdbsum/5JTO PDBsum 5JTP http://www.ebi.ac.uk/pdbsum/5JTP PDBsum 5JTQ http://www.ebi.ac.uk/pdbsum/5JTQ PDBsum 5JTR http://www.ebi.ac.uk/pdbsum/5JTR PRINTS PR01594 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01594 PSORT swissprot:SECB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SECB_ECOLI PSORT-B swissprot:SECB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SECB_ECOLI PSORT2 swissprot:SECB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SECB_ECOLI Pfam PF02556 http://pfam.xfam.org/family/PF02556 Phobius swissprot:SECB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SECB_ECOLI PhylomeDB P0AG86 http://phylomedb.org/?seqid=P0AG86 ProteinModelPortal P0AG86 http://www.proteinmodelportal.org/query/uniprot/P0AG86 PubMed 14643199 http://www.ncbi.nlm.nih.gov/pubmed/14643199 PubMed 16352602 http://www.ncbi.nlm.nih.gov/pubmed/16352602 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17938627 http://www.ncbi.nlm.nih.gov/pubmed/17938627 PubMed 2656409 http://www.ncbi.nlm.nih.gov/pubmed/2656409 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_418066 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418066 RefSeq WP_000003377 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000003377 SMR P0AG86 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AG86 STRING 511145.b3609 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3609&targetmode=cogs STRING COG1952 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1952&targetmode=cogs SUPFAM SSF54611 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54611 TIGRFAMs TIGR00809 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00809 UniProtKB SECB_ECOLI http://www.uniprot.org/uniprot/SECB_ECOLI UniProtKB-AC P0AG86 http://www.uniprot.org/uniprot/P0AG86 charge swissprot:SECB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SECB_ECOLI eggNOG COG1952 http://eggnogapi.embl.de/nog_data/html/tree/COG1952 eggNOG ENOG4105IX2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105IX2 epestfind swissprot:SECB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SECB_ECOLI garnier swissprot:SECB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SECB_ECOLI helixturnhelix swissprot:SECB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SECB_ECOLI hmoment swissprot:SECB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SECB_ECOLI iep swissprot:SECB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SECB_ECOLI inforesidue swissprot:SECB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SECB_ECOLI octanol swissprot:SECB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SECB_ECOLI pepcoil swissprot:SECB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SECB_ECOLI pepdigest swissprot:SECB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SECB_ECOLI pepinfo swissprot:SECB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SECB_ECOLI pepnet swissprot:SECB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SECB_ECOLI pepstats swissprot:SECB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SECB_ECOLI pepwheel swissprot:SECB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SECB_ECOLI pepwindow swissprot:SECB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SECB_ECOLI sigcleave swissprot:SECB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SECB_ECOLI ## Database ID URL or Descriptions # BioGrid 4259411 135 # EcoGene EG11522 ybfB # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # Organism YBFB_ECOLI Escherichia coli (strain K12) # PIR E64805 E64805 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBFB_ECOLI Uncharacterized protein YbfB # RefSeq NP_415230 NC_000913.3 # RefSeq WP_000873944 NZ_LN832404.1 # SUBCELLULAR LOCATION YBFB_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # eggNOG ENOG41079JQ Bacteria # eggNOG ENOG410ZEKG LUCA BLAST swissprot:YBFB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBFB_ECOLI BioCyc ECOL316407:JW0691-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0691-MONOMER BioCyc EcoCyc:EG11522-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11522-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L02373 http://www.ebi.ac.uk/ena/data/view/L02373 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1484 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1484 EcoGene EG11522 http://www.ecogene.org/geneInfo.php?eg_id=EG11522 EnsemblBacteria AAC73796 http://www.ensemblgenomes.org/id/AAC73796 EnsemblBacteria AAC73796 http://www.ensemblgenomes.org/id/AAC73796 EnsemblBacteria BAA35360 http://www.ensemblgenomes.org/id/BAA35360 EnsemblBacteria BAA35360 http://www.ensemblgenomes.org/id/BAA35360 EnsemblBacteria BAA35360 http://www.ensemblgenomes.org/id/BAA35360 EnsemblBacteria b0702 http://www.ensemblgenomes.org/id/b0702 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 947566 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947566 KEGG_Gene ecj:JW0691 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0691 KEGG_Gene eco:b0702 http://www.genome.jp/dbget-bin/www_bget?eco:b0702 OMA EDIMYDV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EDIMYDV PSORT swissprot:YBFB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBFB_ECOLI PSORT-B swissprot:YBFB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBFB_ECOLI PSORT2 swissprot:YBFB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBFB_ECOLI Phobius swissprot:YBFB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBFB_ECOLI ProteinModelPortal P0AAU5 http://www.proteinmodelportal.org/query/uniprot/P0AAU5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8387990 http://www.ncbi.nlm.nih.gov/pubmed/8387990 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415230 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415230 RefSeq WP_000873944 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000873944 STRING 511145.b0702 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0702&targetmode=cogs UniProtKB YBFB_ECOLI http://www.uniprot.org/uniprot/YBFB_ECOLI UniProtKB-AC P0AAU5 http://www.uniprot.org/uniprot/P0AAU5 charge swissprot:YBFB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBFB_ECOLI eggNOG ENOG41079JQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG41079JQ eggNOG ENOG410ZEKG http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZEKG epestfind swissprot:YBFB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBFB_ECOLI garnier swissprot:YBFB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBFB_ECOLI helixturnhelix swissprot:YBFB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBFB_ECOLI hmoment swissprot:YBFB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBFB_ECOLI iep swissprot:YBFB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBFB_ECOLI inforesidue swissprot:YBFB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBFB_ECOLI octanol swissprot:YBFB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBFB_ECOLI pepcoil swissprot:YBFB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBFB_ECOLI pepdigest swissprot:YBFB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBFB_ECOLI pepinfo swissprot:YBFB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBFB_ECOLI pepnet swissprot:YBFB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBFB_ECOLI pepstats swissprot:YBFB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBFB_ECOLI pepwheel swissprot:YBFB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBFB_ECOLI pepwindow swissprot:YBFB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBFB_ECOLI sigcleave swissprot:YBFB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBFB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260482 31 # EcoGene EG12054 ccmF # FUNCTION CCMF_ECOLI Required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_function GO:0015232 heme transporter activity; IEA:InterPro. # GO_function GO:0020037 heme binding; IMP:EcoCyc. # GO_process GO:0018063 cytochrome c-heme linkage; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0006464 cellular protein modification process # INTERACTION CCMF_ECOLI P0ABM9 ccmH; NbExp=3; IntAct=EBI-763370, EBI-560309; # IntAct P33927 3 # InterPro IPR002541 Cyt_c_assembly # InterPro IPR003567 Cyt_c_biogenesis # InterPro IPR003568 Cyt_c_biogenesis_CcmF # InterPro IPR032523 CcmF_C # KEGG_Brite ko02000 Transporters # Organism CCMF_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30009:SF0 PTHR30009:SF0; 2 # PATRIC 32119751 VBIEscCol129921_2285 # PIR B64989 B64989 # PRINTS PR01410 CCBIOGENESIS # PRINTS PR01411 CCMFBIOGNSIS # Pfam PF01578 Cytochrom_C_asm # Pfam PF16327 CcmF_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CCMF_ECOLI Cytochrome c-type biogenesis protein CcmF # RefSeq NP_416700 NC_000913.3 # RefSeq WP_000982447 NZ_LN832404.1 # SIMILARITY Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family. {ECO 0000305}. # SUBCELLULAR LOCATION CCMF_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 9.B.14.1 the putative heme handling protein (hhp) family # TIGRFAMs TIGR00353 nrfE # eggNOG COG1138 LUCA # eggNOG ENOG4105DA4 Bacteria BLAST swissprot:CCMF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CCMF_ECOLI BioCyc ECOL316407:JW2184-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2184-MONOMER BioCyc EcoCyc:EG12054-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12054-MONOMER COG COG1138 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1138 DIP DIP-9256N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9256N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00008 http://www.ebi.ac.uk/ena/data/view/U00008 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1985 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1985 EcoGene EG12054 http://www.ecogene.org/geneInfo.php?eg_id=EG12054 EnsemblBacteria AAC75256 http://www.ensemblgenomes.org/id/AAC75256 EnsemblBacteria AAC75256 http://www.ensemblgenomes.org/id/AAC75256 EnsemblBacteria BAE76659 http://www.ensemblgenomes.org/id/BAE76659 EnsemblBacteria BAE76659 http://www.ensemblgenomes.org/id/BAE76659 EnsemblBacteria BAE76659 http://www.ensemblgenomes.org/id/BAE76659 EnsemblBacteria b2196 http://www.ensemblgenomes.org/id/b2196 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015232 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015232 GO_function GO:0020037 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0020037 GO_process GO:0018063 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018063 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GeneID 948783 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948783 HOGENOM HOG000274659 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000274659&db=HOGENOM6 InParanoid P33927 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33927 IntAct P33927 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33927* InterPro IPR002541 http://www.ebi.ac.uk/interpro/entry/IPR002541 InterPro IPR003567 http://www.ebi.ac.uk/interpro/entry/IPR003567 InterPro IPR003568 http://www.ebi.ac.uk/interpro/entry/IPR003568 InterPro IPR032523 http://www.ebi.ac.uk/interpro/entry/IPR032523 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2184 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2184 KEGG_Gene eco:b2196 http://www.genome.jp/dbget-bin/www_bget?eco:b2196 KEGG_Orthology KO:K02198 http://www.genome.jp/dbget-bin/www_bget?KO:K02198 MINT MINT-225079 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-225079 OMA QRATHRE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QRATHRE PANTHER PTHR30009:SF0 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30009:SF0 PRINTS PR01410 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01410 PRINTS PR01411 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01411 PSORT swissprot:CCMF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CCMF_ECOLI PSORT-B swissprot:CCMF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CCMF_ECOLI PSORT2 swissprot:CCMF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CCMF_ECOLI Pfam PF01578 http://pfam.xfam.org/family/PF01578 Pfam PF16327 http://pfam.xfam.org/family/PF16327 Phobius swissprot:CCMF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CCMF_ECOLI PhylomeDB P33927 http://phylomedb.org/?seqid=P33927 ProteinModelPortal P33927 http://www.proteinmodelportal.org/query/uniprot/P33927 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7635817 http://www.ncbi.nlm.nih.gov/pubmed/7635817 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416700 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416700 RefSeq WP_000982447 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000982447 STRING 511145.b2196 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2196&targetmode=cogs STRING COG1138 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1138&targetmode=cogs TCDB 9.B.14.1 http://www.tcdb.org/search/result.php?tc=9.B.14.1 TIGRFAMs TIGR00353 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00353 UniProtKB CCMF_ECOLI http://www.uniprot.org/uniprot/CCMF_ECOLI UniProtKB-AC P33927 http://www.uniprot.org/uniprot/P33927 charge swissprot:CCMF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CCMF_ECOLI eggNOG COG1138 http://eggnogapi.embl.de/nog_data/html/tree/COG1138 eggNOG ENOG4105DA4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DA4 epestfind swissprot:CCMF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CCMF_ECOLI garnier swissprot:CCMF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CCMF_ECOLI helixturnhelix swissprot:CCMF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CCMF_ECOLI hmoment swissprot:CCMF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CCMF_ECOLI iep swissprot:CCMF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CCMF_ECOLI inforesidue swissprot:CCMF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CCMF_ECOLI octanol swissprot:CCMF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CCMF_ECOLI pepcoil swissprot:CCMF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CCMF_ECOLI pepdigest swissprot:CCMF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CCMF_ECOLI pepinfo swissprot:CCMF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CCMF_ECOLI pepnet swissprot:CCMF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CCMF_ECOLI pepstats swissprot:CCMF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CCMF_ECOLI pepwheel swissprot:CCMF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CCMF_ECOLI pepwindow swissprot:CCMF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CCMF_ECOLI sigcleave swissprot:CCMF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CCMF_ECOLI ## Database ID URL or Descriptions # BioGrid 4262996 181 # DISRUPTION PHENOTYPE Cells missing tonB survive hydroxyurea treatment better than wild-type; further disruption of mazE-mazF and relE-relB yields even better survival (PubMed:20005847). {ECO 0000269|PubMed:20005847}. # EcoGene EG11012 tonB # FUNCTION TONB_ECOLI Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates such as cobalamin, and various iron compounds (such as iron dicitrate, enterochelin, aerobactin, etc.). In the absence of TonB these receptors bind their substrates but do not carry out active transport. TonB also interacts with some colicins and is involved in the energy- dependent, irreversible steps of bacteriophages phi 80 and T1 infection. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Implicated in hydroxy radical-mediated cell death induced by hydroxyurea treatment (PubMed 20005847). {ECO 0000269|PubMed 20005847}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IEA:InterPro. # GO_component GO:0031233 intrinsic component of external side of plasma membrane; IMP:EcoCyc. # GO_function GO:0015343 siderophore transmembrane transporter activity; IEA:InterPro. # GO_function GO:0031992 energy transducer activity; IDA:EcoCyc. # GO_process GO:0015031 protein transport; IEA:UniProtKB-KW. # GO_process GO:0015889 cobalamin transport; IMP:EcoCyc. # GO_process GO:0015891 siderophore transport; TAS:EcoCyc. # GO_process GO:0042914 colicin transport; TAS:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # INDUCTION 2-fold by hydroxyurea treatment. {ECO:0000269|PubMed 20005847}. # INTERACTION TONB_ECOLI P0ABU7 exbB; NbExp=2; IntAct=EBI-6399993, EBI-6399986; P0ABV2 exbD; NbExp=3; IntAct=EBI-6399993, EBI-6417016; P05825 fepA; NbExp=2; IntAct=EBI-6399993, EBI-6400027; P69776 lpp; NbExp=2; IntAct=EBI-6399993, EBI-909750; # IntAct P02929 5 # InterPro IPR003538 TonB # InterPro IPR006260 TonB_C # KEGG_Brite ko02000 Transporters # Organism TONB_ECOLI Escherichia coli (strain K12) # PATRIC 32117764 VBIEscCol129921_1302 # PDB 1IHR X-ray; 1.55 A; A/B=164-239 # PDB 1QXX X-ray; 2.70 A; A=164-239 # PDB 1U07 X-ray; 1.13 A; A/B=150-239 # PDB 1XX3 NMR; -; A=103-239 # PDB 2GRX X-ray; 3.30 A; C/D=31-239 # PDB 2GSK X-ray; 2.10 A; B=153-233 # PIR G64872 BVEC # PRINTS PR01374 TONBPROTEIN # Pfam PF03544 TonB_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TONB_ECOLI Protein TonB # RefSeq NP_415768 NC_000913.3 # RefSeq WP_001360141 NZ_LN832404.1 # SEQUENCE CAUTION TONB_ECOLI Sequence=AAB59066.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=AAB60069.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=AAB60077.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=AAB60085.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=AAB60093.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=AAB60101.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=AAB60109.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=AAB60117.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=AAB60125.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=AAB60133.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=AAB60141.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=AAB60149.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=AAB60157.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the TonB family. {ECO 0000305}. # SUBCELLULAR LOCATION TONB_ECOLI Cell inner membrane; Single-pass membrane protein; Periplasmic side. # SUBUNIT TONB_ECOLI Homodimer. Forms a complex with the accessory proteins ExbB and ExbD. # TCDB 2.C.1.1 the tonb-exbb-exbd/tola-tolq-tolr (tonb) family of auxiliary proteins for energization of outer membrane receptor (omr)-mediated active transport # TIGRFAMs TIGR01352 tonB_Cterm # eggNOG COG0810 LUCA # eggNOG ENOG410822N Bacteria BLAST swissprot:TONB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TONB_ECOLI BioCyc ECOL316407:JW5195-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5195-MONOMER BioCyc EcoCyc:EG11012-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11012-MONOMER BioCyc MetaCyc:EG11012-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11012-MONOMER COG COG0810 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0810 DIP DIP-48111N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48111N DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.80.17.5235 http://dx.doi.org/10.1073/pnas.80.17.5235 DOI 10.1074/jbc.M102778200 http://dx.doi.org/10.1074/jbc.M102778200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1111/j.1365-2958.1993.tb01581.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb01581.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DisProt DP00043 http://www.disprot.org/protein.php?id=DP00043 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K00431 http://www.ebi.ac.uk/ena/data/view/K00431 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U24195 http://www.ebi.ac.uk/ena/data/view/U24195 EMBL U24196 http://www.ebi.ac.uk/ena/data/view/U24196 EMBL U24197 http://www.ebi.ac.uk/ena/data/view/U24197 EMBL U24198 http://www.ebi.ac.uk/ena/data/view/U24198 EMBL U24199 http://www.ebi.ac.uk/ena/data/view/U24199 EMBL U24200 http://www.ebi.ac.uk/ena/data/view/U24200 EMBL U24201 http://www.ebi.ac.uk/ena/data/view/U24201 EMBL U24202 http://www.ebi.ac.uk/ena/data/view/U24202 EMBL U24203 http://www.ebi.ac.uk/ena/data/view/U24203 EMBL U24204 http://www.ebi.ac.uk/ena/data/view/U24204 EMBL U24205 http://www.ebi.ac.uk/ena/data/view/U24205 EMBL U24206 http://www.ebi.ac.uk/ena/data/view/U24206 EchoBASE EB1005 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1005 EcoGene EG11012 http://www.ecogene.org/geneInfo.php?eg_id=EG11012 EnsemblBacteria AAC74334 http://www.ensemblgenomes.org/id/AAC74334 EnsemblBacteria AAC74334 http://www.ensemblgenomes.org/id/AAC74334 EnsemblBacteria BAA14784 http://www.ensemblgenomes.org/id/BAA14784 EnsemblBacteria BAA14784 http://www.ensemblgenomes.org/id/BAA14784 EnsemblBacteria BAA14784 http://www.ensemblgenomes.org/id/BAA14784 EnsemblBacteria b1252 http://www.ensemblgenomes.org/id/b1252 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_component GO:0031233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031233 GO_function GO:0015343 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015343 GO_function GO:0031992 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031992 GO_process GO:0015031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031 GO_process GO:0015889 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015889 GO_process GO:0015891 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015891 GO_process GO:0042914 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042914 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 945843 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945843 InParanoid P02929 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P02929 IntAct P02929 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P02929* InterPro IPR003538 http://www.ebi.ac.uk/interpro/entry/IPR003538 InterPro IPR006260 http://www.ebi.ac.uk/interpro/entry/IPR006260 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5195 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5195 KEGG_Gene eco:b1252 http://www.genome.jp/dbget-bin/www_bget?eco:b1252 KEGG_Orthology KO:K03832 http://www.genome.jp/dbget-bin/www_bget?KO:K03832 OMA KWRYEPG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KWRYEPG PDB 1IHR http://www.ebi.ac.uk/pdbe-srv/view/entry/1IHR PDB 1QXX http://www.ebi.ac.uk/pdbe-srv/view/entry/1QXX PDB 1U07 http://www.ebi.ac.uk/pdbe-srv/view/entry/1U07 PDB 1XX3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1XX3 PDB 2GRX http://www.ebi.ac.uk/pdbe-srv/view/entry/2GRX PDB 2GSK http://www.ebi.ac.uk/pdbe-srv/view/entry/2GSK PDBsum 1IHR http://www.ebi.ac.uk/pdbsum/1IHR PDBsum 1QXX http://www.ebi.ac.uk/pdbsum/1QXX PDBsum 1U07 http://www.ebi.ac.uk/pdbsum/1U07 PDBsum 1XX3 http://www.ebi.ac.uk/pdbsum/1XX3 PDBsum 2GRX http://www.ebi.ac.uk/pdbsum/2GRX PDBsum 2GSK http://www.ebi.ac.uk/pdbsum/2GSK PRINTS PR01374 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01374 PSORT swissprot:TONB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TONB_ECOLI PSORT-B swissprot:TONB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TONB_ECOLI PSORT2 swissprot:TONB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TONB_ECOLI Pfam PF03544 http://pfam.xfam.org/family/PF03544 Phobius swissprot:TONB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TONB_ECOLI ProteinModelPortal P02929 http://www.proteinmodelportal.org/query/uniprot/P02929 PubMed 11328822 http://www.ncbi.nlm.nih.gov/pubmed/11328822 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1885532 http://www.ncbi.nlm.nih.gov/pubmed/1885532 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 6310567 http://www.ncbi.nlm.nih.gov/pubmed/6310567 PubMed 8316087 http://www.ncbi.nlm.nih.gov/pubmed/8316087 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415768 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415768 RefSeq WP_001360141 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001360141 SMR P02929 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P02929 STRING 511145.b1252 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1252&targetmode=cogs STRING COG0810 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0810&targetmode=cogs TCDB 2.C.1.1 http://www.tcdb.org/search/result.php?tc=2.C.1.1 TIGRFAMs TIGR01352 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01352 UniProtKB TONB_ECOLI http://www.uniprot.org/uniprot/TONB_ECOLI UniProtKB-AC P02929 http://www.uniprot.org/uniprot/P02929 charge swissprot:TONB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TONB_ECOLI eggNOG COG0810 http://eggnogapi.embl.de/nog_data/html/tree/COG0810 eggNOG ENOG410822N http://eggnogapi.embl.de/nog_data/html/tree/ENOG410822N epestfind swissprot:TONB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TONB_ECOLI garnier swissprot:TONB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TONB_ECOLI helixturnhelix swissprot:TONB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TONB_ECOLI hmoment swissprot:TONB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TONB_ECOLI iep swissprot:TONB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TONB_ECOLI inforesidue swissprot:TONB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TONB_ECOLI octanol swissprot:TONB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TONB_ECOLI pepcoil swissprot:TONB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TONB_ECOLI pepdigest swissprot:TONB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TONB_ECOLI pepinfo swissprot:TONB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TONB_ECOLI pepnet swissprot:TONB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TONB_ECOLI pepstats swissprot:TONB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TONB_ECOLI pepwheel swissprot:TONB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TONB_ECOLI pepwindow swissprot:TONB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TONB_ECOLI sigcleave swissprot:TONB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TONB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260847 12 # EcoGene EG13147 yafJ # GO_function GO:0016740 transferase activity; IEA:UniProtKB-KW. # GO_process GO:0006541 glutamine metabolic process; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006520 cellular amino acid metabolic process # Gene3D 3.60.20.10 -; 1. # INTERACTION YAFJ_ECOLI P12996 bioB; NbExp=4; IntAct=EBI-1114805, EBI-557917; # IntAct Q47147 14 # InterPro IPR017932 GATase_2_dom # InterPro IPR026869 Put_GATase_2 # InterPro IPR029055 Ntn_hydrolases_N # Organism YAFJ_ECOLI Escherichia coli (strain K12) # PATRIC 32115561 VBIEscCol129921_0225 # PIR H64746 H64746 # PROSITE PS51278 GATASE_TYPE_2 # Pfam PF13230 GATase_4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAFJ_ECOLI Putative glutamine amidotransferase YafJ # RefSeq NP_414758 NC_000913.3 # RefSeq WP_000333380 NZ_LN832404.1 # SIMILARITY Contains 1 glutamine amidotransferase type-2 domain. {ECO:0000255|PROSITE-ProRule PRU00609}. # SUPFAM SSF56235 SSF56235 # eggNOG COG0121 LUCA # eggNOG ENOG4105E7A Bacteria BLAST swissprot:YAFJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAFJ_ECOLI BioCyc ECOL316407:JW0213-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0213-MONOMER BioCyc EcoCyc:G6107-MONOMER http://biocyc.org/getid?id=EcoCyc:G6107-MONOMER COG COG0121 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0121 DOI 10.1016/0165-7992(95)90024-1 http://dx.doi.org/10.1016/0165-7992(95)90024-1 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.4.2.- http://www.genome.jp/dbget-bin/www_bget?EC:2.4.2.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D38582 http://www.ebi.ac.uk/ena/data/view/D38582 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 ENZYME 2.4.2.- http://enzyme.expasy.org/EC/2.4.2.- EchoBASE EB2941 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2941 EcoGene EG13147 http://www.ecogene.org/geneInfo.php?eg_id=EG13147 EnsemblBacteria AAC73327 http://www.ensemblgenomes.org/id/AAC73327 EnsemblBacteria AAC73327 http://www.ensemblgenomes.org/id/AAC73327 EnsemblBacteria BAA77893 http://www.ensemblgenomes.org/id/BAA77893 EnsemblBacteria BAA77893 http://www.ensemblgenomes.org/id/BAA77893 EnsemblBacteria BAA77893 http://www.ensemblgenomes.org/id/BAA77893 EnsemblBacteria b0223 http://www.ensemblgenomes.org/id/b0223 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016740 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016740 GO_process GO:0006541 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006541 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 Gene3D 3.60.20.10 http://www.cathdb.info/version/latest/superfamily/3.60.20.10 GeneID 944906 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944906 HOGENOM HOG000256248 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000256248&db=HOGENOM6 InParanoid Q47147 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q47147 IntAct Q47147 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q47147* IntEnz 2.4.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.2 InterPro IPR017932 http://www.ebi.ac.uk/interpro/entry/IPR017932 InterPro IPR026869 http://www.ebi.ac.uk/interpro/entry/IPR026869 InterPro IPR029055 http://www.ebi.ac.uk/interpro/entry/IPR029055 KEGG_Gene ecj:JW0213 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0213 KEGG_Gene eco:b0223 http://www.genome.jp/dbget-bin/www_bget?eco:b0223 KEGG_Orthology KO:K07008 http://www.genome.jp/dbget-bin/www_bget?KO:K07008 OMA YWVFAHN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YWVFAHN PROSITE PS51278 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51278 PSORT swissprot:YAFJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAFJ_ECOLI PSORT-B swissprot:YAFJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAFJ_ECOLI PSORT2 swissprot:YAFJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAFJ_ECOLI Pfam PF13230 http://pfam.xfam.org/family/PF13230 Phobius swissprot:YAFJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAFJ_ECOLI PhylomeDB Q47147 http://phylomedb.org/?seqid=Q47147 ProteinModelPortal Q47147 http://www.proteinmodelportal.org/query/uniprot/Q47147 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7596361 http://www.ncbi.nlm.nih.gov/pubmed/7596361 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414758 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414758 RefSeq WP_000333380 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000333380 SMR Q47147 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q47147 STRING 511145.b0223 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0223&targetmode=cogs STRING COG0121 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0121&targetmode=cogs SUPFAM SSF56235 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56235 UniProtKB YAFJ_ECOLI http://www.uniprot.org/uniprot/YAFJ_ECOLI UniProtKB-AC Q47147 http://www.uniprot.org/uniprot/Q47147 charge swissprot:YAFJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAFJ_ECOLI eggNOG COG0121 http://eggnogapi.embl.de/nog_data/html/tree/COG0121 eggNOG ENOG4105E7A http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E7A epestfind swissprot:YAFJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAFJ_ECOLI garnier swissprot:YAFJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAFJ_ECOLI helixturnhelix swissprot:YAFJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAFJ_ECOLI hmoment swissprot:YAFJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAFJ_ECOLI iep swissprot:YAFJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAFJ_ECOLI inforesidue swissprot:YAFJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAFJ_ECOLI octanol swissprot:YAFJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAFJ_ECOLI pepcoil swissprot:YAFJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAFJ_ECOLI pepdigest swissprot:YAFJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAFJ_ECOLI pepinfo swissprot:YAFJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAFJ_ECOLI pepnet swissprot:YAFJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAFJ_ECOLI pepstats swissprot:YAFJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAFJ_ECOLI pepwheel swissprot:YAFJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAFJ_ECOLI pepwindow swissprot:YAFJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAFJ_ECOLI sigcleave swissprot:YAFJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAFJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4259167 3 # CDD cd06259 YdcF-like # EcoGene EG12025 sanA # FUNCTION SANA_ECOLI Participates in the barrier function of the cell envelope. # GO_component GO:0005886 plasma membrane; IBA:GO_Central. # GO_component GO:0016021 integral component of membrane; IDA:EcoCyc. # GO_process GO:0042493 response to drug; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.620 -; 1. # IntAct P0AFY2 2 # InterPro IPR003848 DUF218 # InterPro IPR014729 Rossmann-like_a/b/a_fold # InterPro IPR023604 Uncharacterised_SanA # Organism SANA_ECOLI Escherichia coli (strain K12) # PATRIC 32119631 VBIEscCol129921_2226 # PIR G64982 G64982 # PIRSF PIRSF005011 SanA # Pfam PF02698 DUF218 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SANA_ECOLI Protein SanA # RefSeq NP_416649 NC_000913.3 # RefSeq WP_000920064 NZ_LN832404.1 # SUBCELLULAR LOCATION SANA_ECOLI Cell inner membrane; Single-pass membrane protein. # TCDB 9.B.114.1 the vanomycin-sensitivity protein (sana) family # eggNOG COG2949 LUCA # eggNOG ENOG4107GZ4 Bacteria BLAST swissprot:SANA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SANA_ECOLI BioCyc ECOL316407:JW2132-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2132-MONOMER BioCyc EcoCyc:EG12025-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12025-MONOMER COG COG2949 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2949 DOI 10.1021/bi00132a003 http://dx.doi.org/10.1021/bi00132a003 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M60916 http://www.ebi.ac.uk/ena/data/view/M60916 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL Z47804 http://www.ebi.ac.uk/ena/data/view/Z47804 EchoBASE EB1960 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1960 EcoGene EG12025 http://www.ecogene.org/geneInfo.php?eg_id=EG12025 EnsemblBacteria AAC75205 http://www.ensemblgenomes.org/id/AAC75205 EnsemblBacteria AAC75205 http://www.ensemblgenomes.org/id/AAC75205 EnsemblBacteria BAE76621 http://www.ensemblgenomes.org/id/BAE76621 EnsemblBacteria BAE76621 http://www.ensemblgenomes.org/id/BAE76621 EnsemblBacteria BAE76621 http://www.ensemblgenomes.org/id/BAE76621 EnsemblBacteria b2144 http://www.ensemblgenomes.org/id/b2144 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0042493 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 GeneID 949003 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949003 HOGENOM HOG000031180 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000031180&db=HOGENOM6 InParanoid P0AFY2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFY2 IntAct P0AFY2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFY2* InterPro IPR003848 http://www.ebi.ac.uk/interpro/entry/IPR003848 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 InterPro IPR023604 http://www.ebi.ac.uk/interpro/entry/IPR023604 KEGG_Gene ecj:JW2132 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2132 KEGG_Gene eco:b2144 http://www.genome.jp/dbget-bin/www_bget?eco:b2144 KEGG_Orthology KO:K03748 http://www.genome.jp/dbget-bin/www_bget?KO:K03748 OMA DNAQQSY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DNAQQSY PSORT swissprot:SANA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SANA_ECOLI PSORT-B swissprot:SANA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SANA_ECOLI PSORT2 swissprot:SANA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SANA_ECOLI Pfam PF02698 http://pfam.xfam.org/family/PF02698 Phobius swissprot:SANA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SANA_ECOLI PhylomeDB P0AFY2 http://phylomedb.org/?seqid=P0AFY2 ProteinModelPortal P0AFY2 http://www.proteinmodelportal.org/query/uniprot/P0AFY2 PubMed 1567863 http://www.ncbi.nlm.nih.gov/pubmed/1567863 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8550448 http://www.ncbi.nlm.nih.gov/pubmed/8550448 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416649 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416649 RefSeq WP_000920064 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000920064 SMR P0AFY2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFY2 STRING 511145.b2144 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2144&targetmode=cogs STRING COG2949 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2949&targetmode=cogs TCDB 9.B.114.1 http://www.tcdb.org/search/result.php?tc=9.B.114.1 UniProtKB SANA_ECOLI http://www.uniprot.org/uniprot/SANA_ECOLI UniProtKB-AC P0AFY2 http://www.uniprot.org/uniprot/P0AFY2 charge swissprot:SANA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SANA_ECOLI eggNOG COG2949 http://eggnogapi.embl.de/nog_data/html/tree/COG2949 eggNOG ENOG4107GZ4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107GZ4 epestfind swissprot:SANA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SANA_ECOLI garnier swissprot:SANA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SANA_ECOLI helixturnhelix swissprot:SANA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SANA_ECOLI hmoment swissprot:SANA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SANA_ECOLI iep swissprot:SANA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SANA_ECOLI inforesidue swissprot:SANA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SANA_ECOLI octanol swissprot:SANA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SANA_ECOLI pepcoil swissprot:SANA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SANA_ECOLI pepdigest swissprot:SANA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SANA_ECOLI pepinfo swissprot:SANA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SANA_ECOLI pepnet swissprot:SANA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SANA_ECOLI pepstats swissprot:SANA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SANA_ECOLI pepwheel swissprot:SANA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SANA_ECOLI pepwindow swissprot:SANA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SANA_ECOLI sigcleave swissprot:SANA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SANA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259576 44 # EcoGene EG11759 yciK # GO_component GO:0005622 intracellular; IBA:GO_Central. # GO_function GO:0016491 oxidoreductase activity; IBA:GO_Central. # GO_process GO:1901575 organic substance catabolic process; IBA:GO_Central. # GOslim_component GO:0005622 intracellular # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0009056 catabolic process # Gene3D 3.40.50.720 -; 1. # IntAct P31808 6 # InterPro IPR002347 SDR_fam # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR020904 Sc_DH/Rdtase_CS # Organism YCIK_ECOLI Escherichia coli (strain K12) # PANTHER PTHR24322 PTHR24322; 2 # PATRIC 32117800 VBIEscCol129921_1320 # PDB 3E9Q X-ray; 1.70 A; A/B=1-252 # PDB 3F1K X-ray; 2.60 A; A=1-252 # PDB 3F1L X-ray; 0.95 A; A/B=1-252 # PIR B64875 B64875 # PRINTS PR00081 GDHRDH # PROSITE PS00061 ADH_SHORT # Pfam PF00106 adh_short # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCIK_ECOLI Uncharacterized oxidoreductase YciK # RefSeq NP_415787 NC_000913.3 # RefSeq WP_000559286 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB59991.1; Type=Frameshift; Positions=115; Evidence={ECO:0000305}; Sequence=AAB59992.1; Type=Frameshift; Positions=115; Evidence={ECO 0000305}; # SIMILARITY Belongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO 0000305}. # SUPFAM SSF51735 SSF51735 # eggNOG COG1028 LUCA # eggNOG ENOG4105UBK Bacteria BLAST swissprot:YCIK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCIK_ECOLI BioCyc ECOL316407:JW1263-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1263-MONOMER BioCyc EcoCyc:EG11759-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11759-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M73320 http://www.ebi.ac.uk/ena/data/view/M73320 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U17433 http://www.ebi.ac.uk/ena/data/view/U17433 EMBL U17433 http://www.ebi.ac.uk/ena/data/view/U17433 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- EchoBASE EB1709 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1709 EcoGene EG11759 http://www.ecogene.org/geneInfo.php?eg_id=EG11759 EnsemblBacteria AAC74353 http://www.ensemblgenomes.org/id/AAC74353 EnsemblBacteria AAC74353 http://www.ensemblgenomes.org/id/AAC74353 EnsemblBacteria BAA14808 http://www.ensemblgenomes.org/id/BAA14808 EnsemblBacteria BAA14808 http://www.ensemblgenomes.org/id/BAA14808 EnsemblBacteria BAA14808 http://www.ensemblgenomes.org/id/BAA14808 EnsemblBacteria b1271 http://www.ensemblgenomes.org/id/b1271 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_process GO:1901575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901575 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 945838 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945838 InParanoid P31808 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31808 IntAct P31808 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31808* IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR002347 http://www.ebi.ac.uk/interpro/entry/IPR002347 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR020904 http://www.ebi.ac.uk/interpro/entry/IPR020904 KEGG_Gene ecj:JW1263 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1263 KEGG_Gene eco:b1271 http://www.genome.jp/dbget-bin/www_bget?eco:b1271 OMA LAHEYED http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LAHEYED PANTHER PTHR24322 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24322 PDB 3E9Q http://www.ebi.ac.uk/pdbe-srv/view/entry/3E9Q PDB 3F1K http://www.ebi.ac.uk/pdbe-srv/view/entry/3F1K PDB 3F1L http://www.ebi.ac.uk/pdbe-srv/view/entry/3F1L PDBsum 3E9Q http://www.ebi.ac.uk/pdbsum/3E9Q PDBsum 3F1K http://www.ebi.ac.uk/pdbsum/3F1K PDBsum 3F1L http://www.ebi.ac.uk/pdbsum/3F1L PRINTS PR00081 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00081 PROSITE PS00061 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00061 PSORT swissprot:YCIK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCIK_ECOLI PSORT-B swissprot:YCIK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCIK_ECOLI PSORT2 swissprot:YCIK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCIK_ECOLI Pfam PF00106 http://pfam.xfam.org/family/PF00106 Phobius swissprot:YCIK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCIK_ECOLI PhylomeDB P31808 http://phylomedb.org/?seqid=P31808 ProteinModelPortal P31808 http://www.proteinmodelportal.org/query/uniprot/P31808 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1885549 http://www.ncbi.nlm.nih.gov/pubmed/1885549 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415787 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415787 RefSeq WP_000559286 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000559286 SMR P31808 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31808 STRING 511145.b1271 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1271&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB YCIK_ECOLI http://www.uniprot.org/uniprot/YCIK_ECOLI UniProtKB-AC P31808 http://www.uniprot.org/uniprot/P31808 charge swissprot:YCIK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCIK_ECOLI eggNOG COG1028 http://eggnogapi.embl.de/nog_data/html/tree/COG1028 eggNOG ENOG4105UBK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105UBK epestfind swissprot:YCIK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCIK_ECOLI garnier swissprot:YCIK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCIK_ECOLI helixturnhelix swissprot:YCIK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCIK_ECOLI hmoment swissprot:YCIK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCIK_ECOLI iep swissprot:YCIK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCIK_ECOLI inforesidue swissprot:YCIK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCIK_ECOLI octanol swissprot:YCIK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCIK_ECOLI pepcoil swissprot:YCIK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCIK_ECOLI pepdigest swissprot:YCIK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCIK_ECOLI pepinfo swissprot:YCIK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCIK_ECOLI pepnet swissprot:YCIK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCIK_ECOLI pepstats swissprot:YCIK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCIK_ECOLI pepwheel swissprot:YCIK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCIK_ECOLI pepwindow swissprot:YCIK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCIK_ECOLI sigcleave swissprot:YCIK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCIK_ECOLI ## Database ID URL or Descriptions # AltName AROF_ECOLI 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase # AltName AROF_ECOLI DAHP synthase # AltName AROF_ECOLI Phospho-2-keto-3-deoxyheptonate aldolase # BioGrid 4263470 18 # CATALYTIC ACTIVITY AROF_ECOLI Phosphoenolpyruvate + D-erythrose 4-phosphate + H(2)O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate. # COFACTOR Name=a divalent metal cation; Xref=ChEBI:CHEBI 60240; # ENZYME REGULATION AROF_ECOLI Specifically feedback inhibited by tyrosine with 50% inhibition observed at 9 microM tyrosine, pH 7.0. # EcoGene EG10078 aroF # FUNCTION AROF_ECOLI Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP). # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0003849 3-deoxy-7-phosphoheptulonate synthase activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0008652 cellular amino acid biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0009073 aromatic amino acid family biosynthetic process; IMP:EcoCyc. # GO_process GO:0009423 chorismate biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.70 -; 1. # IntAct P00888 3 # InterPro IPR006218 DAHP1/KDSA # InterPro IPR006219 DHAP_synth_1 # InterPro IPR013785 Aldolase_TIM # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis # MISCELLANEOUS AROF_ECOLI There are 3 DAHP synthases, AroF is feedback- inhibited by Tyr. The other 2 DAHP synthases are Phe- and Trp- sensitive, respectively. # Organism AROF_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21225 PTHR21225 # PATHWAY Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate step 1/7. # PATRIC 32120601 VBIEscCol129921_2699 # PIR I41141 ADECHY # PIRSF PIRSF001361 DAHP_synthase # Pfam PF00793 DAHP_synth_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AROF_ECOLI Phospho-2-dehydro-3-deoxyheptonate aldolase, Tyr-sensitive # RefSeq NP_417092 NC_000913.3 # RefSeq WP_001168037 NZ_LN832404.1 # SIMILARITY Belongs to the class-I DAHP synthase family. {ECO 0000305}. # TIGRFAMs TIGR00034 aroFGH # UniPathway UPA00053 UER00084 # eggNOG COG0722 LUCA # eggNOG ENOG4105E99 Bacteria BLAST swissprot:AROF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AROF_ECOLI BioCyc ECOL316407:JW2582-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2582-MONOMER BioCyc EcoCyc:AROF-MONOMER http://biocyc.org/getid?id=EcoCyc:AROF-MONOMER BioCyc MetaCyc:AROF-MONOMER http://biocyc.org/getid?id=MetaCyc:AROF-MONOMER COG COG0722 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0722 DIP DIP-9154N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9154N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/prep.1996.0690 http://dx.doi.org/10.1006/prep.1996.0690 DOI 10.1016/0022-2836(84)90269-9 http://dx.doi.org/10.1016/0022-2836(84)90269-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.5.1.54 http://www.genome.jp/dbget-bin/www_bget?EC:2.5.1.54 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K01989 http://www.ebi.ac.uk/ena/data/view/K01989 EMBL K03453 http://www.ebi.ac.uk/ena/data/view/K03453 EMBL M10431 http://www.ebi.ac.uk/ena/data/view/M10431 EMBL M60890 http://www.ebi.ac.uk/ena/data/view/M60890 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.5.1.54 http://enzyme.expasy.org/EC/2.5.1.54 EchoBASE EB0076 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0076 EcoGene EG10078 http://www.ecogene.org/geneInfo.php?eg_id=EG10078 EnsemblBacteria AAC75650 http://www.ensemblgenomes.org/id/AAC75650 EnsemblBacteria AAC75650 http://www.ensemblgenomes.org/id/AAC75650 EnsemblBacteria BAA16487 http://www.ensemblgenomes.org/id/BAA16487 EnsemblBacteria BAA16487 http://www.ensemblgenomes.org/id/BAA16487 EnsemblBacteria BAA16487 http://www.ensemblgenomes.org/id/BAA16487 EnsemblBacteria b2601 http://www.ensemblgenomes.org/id/b2601 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003849 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003849 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0008652 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008652 GO_process GO:0009073 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009073 GO_process GO:0009423 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009423 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016765 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 947084 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947084 HOGENOM HOG000220501 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220501&db=HOGENOM6 InParanoid P00888 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00888 IntAct P00888 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00888* IntEnz 2.5.1.54 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.5.1.54 InterPro IPR006218 http://www.ebi.ac.uk/interpro/entry/IPR006218 InterPro IPR006219 http://www.ebi.ac.uk/interpro/entry/IPR006219 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2582 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2582 KEGG_Gene eco:b2601 http://www.genome.jp/dbget-bin/www_bget?eco:b2601 KEGG_Orthology KO:K01626 http://www.genome.jp/dbget-bin/www_bget?KO:K01626 KEGG_Pathway ko00400 http://www.genome.jp/kegg-bin/show_pathway?ko00400 KEGG_Reaction rn:R01826 http://www.genome.jp/dbget-bin/www_bget?rn:R01826 OMA SWETTDA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SWETTDA PANTHER PTHR21225 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21225 PSORT swissprot:AROF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AROF_ECOLI PSORT-B swissprot:AROF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AROF_ECOLI PSORT2 swissprot:AROF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AROF_ECOLI Pfam PF00793 http://pfam.xfam.org/family/PF00793 Phobius swissprot:AROF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AROF_ECOLI PhylomeDB P00888 http://phylomedb.org/?seqid=P00888 ProteinModelPortal P00888 http://www.proteinmodelportal.org/query/uniprot/P00888 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1977738 http://www.ncbi.nlm.nih.gov/pubmed/1977738 PubMed 2857723 http://www.ncbi.nlm.nih.gov/pubmed/2857723 PubMed 6104668 http://www.ncbi.nlm.nih.gov/pubmed/6104668 PubMed 6146618 http://www.ncbi.nlm.nih.gov/pubmed/6146618 PubMed 6396419 http://www.ncbi.nlm.nih.gov/pubmed/6396419 PubMed 9056491 http://www.ncbi.nlm.nih.gov/pubmed/9056491 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417092 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417092 RefSeq WP_001168037 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001168037 SMR P00888 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00888 STRING 511145.b2601 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2601&targetmode=cogs STRING COG0722 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0722&targetmode=cogs SWISS-2DPAGE P00888 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P00888 TIGRFAMs TIGR00034 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00034 UniProtKB AROF_ECOLI http://www.uniprot.org/uniprot/AROF_ECOLI UniProtKB-AC P00888 http://www.uniprot.org/uniprot/P00888 charge swissprot:AROF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AROF_ECOLI eggNOG COG0722 http://eggnogapi.embl.de/nog_data/html/tree/COG0722 eggNOG ENOG4105E99 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E99 epestfind swissprot:AROF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AROF_ECOLI garnier swissprot:AROF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AROF_ECOLI helixturnhelix swissprot:AROF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AROF_ECOLI hmoment swissprot:AROF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AROF_ECOLI iep swissprot:AROF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AROF_ECOLI inforesidue swissprot:AROF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AROF_ECOLI octanol swissprot:AROF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AROF_ECOLI pepcoil swissprot:AROF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AROF_ECOLI pepdigest swissprot:AROF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AROF_ECOLI pepinfo swissprot:AROF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AROF_ECOLI pepnet swissprot:AROF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AROF_ECOLI pepstats swissprot:AROF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AROF_ECOLI pepwheel swissprot:AROF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AROF_ECOLI pepwindow swissprot:AROF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AROF_ECOLI sigcleave swissprot:AROF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AROF_ECOLI ## Database ID URL or Descriptions # BioGrid 4263377 8 # EcoGene EG11504 metQ # FUNCTION METQ_ECOLI This protein is a component of a D-methionine permease, a binding protein-dependent, ATP-driven transport system. {ECO 0000269|PubMed 12169620}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_process GO:0006865 amino acid transport; IEA:UniProtKB-KW. # GO_process GO:0048473 D-methionine transport; IMP:CACAO. # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006810 transport # IntAct P28635 3 # InterPro IPR004872 Lipoprotein_NlpA # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00238 D-Methionine transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # MISCELLANEOUS METQ_ECOLI The MetNIQ system is also to be able to transport the toxic methionine analog alpha-methyl-methionine. # Organism METQ_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30429 PTHR30429 # PATRIC 32115507 VBIEscCol129921_0205 # PDB 4YAH X-ray; 1.60 A; X=1-271 # PIR E64744 E64744 # PIRSF PIRSF002854 MetQ # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF03180 Lipoprotein_9 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName METQ_ECOLI D-methionine-binding lipoprotein MetQ # RefSeq NP_414739 NC_000913.3 # RefSeq WP_000874226 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA24507.1; Type=Frameshift; Positions=217; Evidence={ECO 0000305}; # SIMILARITY Belongs to the NlpA lipoprotein family. {ECO 0000305}. # SUBCELLULAR LOCATION METQ_ECOLI Cell membrane {ECO 0000305}; Lipid-anchor {ECO 0000305}. # TCDB 3.A.1.24 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR00363 TIGR00363 # eggNOG COG1464 LUCA # eggNOG ENOG4105D01 Bacteria BLAST swissprot:METQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:METQ_ECOLI BioCyc ECOL316407:JW0193-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0193-MONOMER BioCyc EcoCyc:METQ-MONOMER http://biocyc.org/getid?id=EcoCyc:METQ-MONOMER BioCyc MetaCyc:METQ-MONOMER http://biocyc.org/getid?id=MetaCyc:METQ-MONOMER COG COG1464 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1464 DIP DIP-11196N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11196N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.17.4930-4932.2002 http://dx.doi.org/10.1128/JB.184.17.4930-4932.2002 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D15061 http://www.ebi.ac.uk/ena/data/view/D15061 EMBL L04474 http://www.ebi.ac.uk/ena/data/view/L04474 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EchoBASE EB1467 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1467 EcoGene EG11504 http://www.ecogene.org/geneInfo.php?eg_id=EG11504 EnsemblBacteria AAC73308 http://www.ensemblgenomes.org/id/AAC73308 EnsemblBacteria AAC73308 http://www.ensemblgenomes.org/id/AAC73308 EnsemblBacteria BAA77874 http://www.ensemblgenomes.org/id/BAA77874 EnsemblBacteria BAA77874 http://www.ensemblgenomes.org/id/BAA77874 EnsemblBacteria BAA77874 http://www.ensemblgenomes.org/id/BAA77874 EnsemblBacteria b0197 http://www.ensemblgenomes.org/id/b0197 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_process GO:0006865 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865 GO_process GO:0048473 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048473 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 944893 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944893 HOGENOM HOG000222926 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000222926&db=HOGENOM6 InParanoid P28635 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P28635 IntAct P28635 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P28635* InterPro IPR004872 http://www.ebi.ac.uk/interpro/entry/IPR004872 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0193 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0193 KEGG_Gene eco:b0197 http://www.genome.jp/dbget-bin/www_bget?eco:b0197 KEGG_Orthology KO:K02073 http://www.genome.jp/dbget-bin/www_bget?KO:K02073 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA NDPANQG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NDPANQG PANTHER PTHR30429 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30429 PDB 4YAH http://www.ebi.ac.uk/pdbe-srv/view/entry/4YAH PDBsum 4YAH http://www.ebi.ac.uk/pdbsum/4YAH PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:METQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:METQ_ECOLI PSORT-B swissprot:METQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:METQ_ECOLI PSORT2 swissprot:METQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:METQ_ECOLI Pfam PF03180 http://pfam.xfam.org/family/PF03180 Phobius swissprot:METQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:METQ_ECOLI PhylomeDB P28635 http://phylomedb.org/?seqid=P28635 ProteinModelPortal P28635 http://www.proteinmodelportal.org/query/uniprot/P28635 PubMed 12169620 http://www.ncbi.nlm.nih.gov/pubmed/12169620 PubMed 1459951 http://www.ncbi.nlm.nih.gov/pubmed/1459951 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414739 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414739 RefSeq WP_000874226 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000874226 SMR P28635 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P28635 STRING 511145.b0197 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0197&targetmode=cogs STRING COG1464 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1464&targetmode=cogs SWISS-2DPAGE P28635 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P28635 TCDB 3.A.1.24 http://www.tcdb.org/search/result.php?tc=3.A.1.24 TIGRFAMs TIGR00363 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00363 UniProtKB METQ_ECOLI http://www.uniprot.org/uniprot/METQ_ECOLI UniProtKB-AC P28635 http://www.uniprot.org/uniprot/P28635 charge swissprot:METQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:METQ_ECOLI eggNOG COG1464 http://eggnogapi.embl.de/nog_data/html/tree/COG1464 eggNOG ENOG4105D01 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D01 epestfind swissprot:METQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:METQ_ECOLI garnier swissprot:METQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:METQ_ECOLI helixturnhelix swissprot:METQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:METQ_ECOLI hmoment swissprot:METQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:METQ_ECOLI iep swissprot:METQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:METQ_ECOLI inforesidue swissprot:METQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:METQ_ECOLI octanol swissprot:METQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:METQ_ECOLI pepcoil swissprot:METQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:METQ_ECOLI pepdigest swissprot:METQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:METQ_ECOLI pepinfo swissprot:METQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:METQ_ECOLI pepnet swissprot:METQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:METQ_ECOLI pepstats swissprot:METQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:METQ_ECOLI pepwheel swissprot:METQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:METQ_ECOLI pepwindow swissprot:METQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:METQ_ECOLI sigcleave swissprot:METQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:METQ_ECOLI ## Database ID URL or Descriptions # EcoGene EG12611 yabQ # Organism YABQ_ECOLI Escherichia coli (strain K12) # PATRIC 48659294 VBIEscCol107702_0053 # PIR A64727 A64727 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YABQ_ECOLI Uncharacterized protein YabQ BLAST swissprot:YABQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YABQ_ECOLI BioCyc ECOL316407:JW0056-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0056-MONOMER BioCyc EcoCyc:EG12611-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12611-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2495 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2495 EcoGene EG12611 http://www.ecogene.org/geneInfo.php?eg_id=EG12611 EnsemblBacteria BAB96625 http://www.ensemblgenomes.org/id/BAB96625 EnsemblBacteria BAB96625 http://www.ensemblgenomes.org/id/BAB96625 EnsemblBacteria BAB96625 http://www.ensemblgenomes.org/id/BAB96625 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv KEGG_Gene ecj:JW0056 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0056 PSORT swissprot:YABQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YABQ_ECOLI PSORT-B swissprot:YABQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YABQ_ECOLI PSORT2 swissprot:YABQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YABQ_ECOLI Phobius swissprot:YABQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YABQ_ECOLI ProteinModelPortal P39221 http://www.proteinmodelportal.org/query/uniprot/P39221 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 STRING 316407.21321938 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.21321938&targetmode=cogs UniProtKB YABQ_ECOLI http://www.uniprot.org/uniprot/YABQ_ECOLI UniProtKB-AC P39221 http://www.uniprot.org/uniprot/P39221 charge swissprot:YABQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YABQ_ECOLI epestfind swissprot:YABQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YABQ_ECOLI garnier swissprot:YABQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YABQ_ECOLI helixturnhelix swissprot:YABQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YABQ_ECOLI hmoment swissprot:YABQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YABQ_ECOLI iep swissprot:YABQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YABQ_ECOLI inforesidue swissprot:YABQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YABQ_ECOLI octanol swissprot:YABQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YABQ_ECOLI pepcoil swissprot:YABQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YABQ_ECOLI pepdigest swissprot:YABQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YABQ_ECOLI pepinfo swissprot:YABQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YABQ_ECOLI pepnet swissprot:YABQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YABQ_ECOLI pepstats swissprot:YABQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YABQ_ECOLI pepwheel swissprot:YABQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YABQ_ECOLI pepwindow swissprot:YABQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YABQ_ECOLI sigcleave swissprot:YABQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YABQ_ECOLI ## Database ID URL or Descriptions # AltName MNTR_ECOLI Manganese transport regulator # BioGrid 4261205 10 # DOMAIN MNTR_ECOLI It contains an N-terminal DNA-binding domain and a metal- binding domain. {ECO 0000269|PubMed 19701940}. # EcoGene EG13322 mntR # FUNCTION MNTR_ECOLI In the presence of manganese, represses expression of mntH and mntS. Up-regulates expression of mntP. {ECO 0000269|PubMed 11466284, ECO 0000269|PubMed 21908668}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IDA:EcoCyc. # GO_function GO:0046914 transition metal ion binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:2000144 positive regulation of DNA-templated transcription, initiation; IEP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # Gene3D 1.10.60.10 -; 1. # INTERACTION MNTR_ECOLI P16433 hycG; NbExp=4; IntAct=EBI-541895, EBI-541977; P30750 metN; NbExp=3; IntAct=EBI-541895, EBI-541886; # IntAct P0A9F1 10 # InterPro IPR001367 Fe_dep_repressor # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR022687 HTH_DTXR # InterPro IPR022689 Iron_dep_repressor # KEGG_Brite ko03000 Transcription factors # Organism MNTR_ECOLI Escherichia coli (strain K12) # PATRIC 32116837 VBIEscCol129921_0844 # PDB 2H09 X-ray; 2.10 A; A=1-155 # PIR A64819 A64819 # PROSITE PS50944 HTH_DTXR # Pfam PF01325 Fe_dep_repress # Pfam PF02742 Fe_dep_repr_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MNTR_ECOLI Transcriptional regulator MntR # RefSeq NP_415338 NC_000913.3 # RefSeq WP_000091016 NZ_LN832404.1 # SIMILARITY Contains 1 HTH dtxR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00296}. # SMART SM00529 HTH_DTXR # SUBCELLULAR LOCATION MNTR_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 19701940}. # SUPFAM SSF46785 SSF46785 # SUPFAM SSF47979 SSF47979 # eggNOG COG1321 LUCA # eggNOG ENOG4105KST Bacteria BLAST swissprot:MNTR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MNTR_ECOLI BioCyc ECOL316407:JW0801-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0801-MONOMER BioCyc EcoCyc:G6420-MONOMER http://biocyc.org/getid?id=EcoCyc:G6420-MONOMER COG COG1321 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1321 DIP DIP-28083N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-28083N DOI 10.1002/prot.22541 http://dx.doi.org/10.1002/prot.22541 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.05872-11 http://dx.doi.org/10.1128/JB.05872-11 DOI 10.1128/JB.183.16.4806-4813.2001 http://dx.doi.org/10.1128/JB.183.16.4806-4813.2001 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3106 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3106 EcoGene EG13322 http://www.ecogene.org/geneInfo.php?eg_id=EG13322 EnsemblBacteria AAC73904 http://www.ensemblgenomes.org/id/AAC73904 EnsemblBacteria AAC73904 http://www.ensemblgenomes.org/id/AAC73904 EnsemblBacteria BAA35488 http://www.ensemblgenomes.org/id/BAA35488 EnsemblBacteria BAA35488 http://www.ensemblgenomes.org/id/BAA35488 EnsemblBacteria BAA35488 http://www.ensemblgenomes.org/id/BAA35488 EnsemblBacteria b0817 http://www.ensemblgenomes.org/id/b0817 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0046914 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046914 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GO_process GO:2000144 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000144 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 1.10.60.10 http://www.cathdb.info/version/latest/superfamily/1.10.60.10 GeneID 945437 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945437 HOGENOM HOG000040349 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000040349&db=HOGENOM6 InParanoid P0A9F1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9F1 IntAct P0A9F1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9F1* InterPro IPR001367 http://www.ebi.ac.uk/interpro/entry/IPR001367 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR022687 http://www.ebi.ac.uk/interpro/entry/IPR022687 InterPro IPR022689 http://www.ebi.ac.uk/interpro/entry/IPR022689 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW0801 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0801 KEGG_Gene eco:b0817 http://www.genome.jp/dbget-bin/www_bget?eco:b0817 KEGG_Orthology KO:K11924 http://www.genome.jp/dbget-bin/www_bget?KO:K11924 OMA CPYVLKQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CPYVLKQ PDB 2H09 http://www.ebi.ac.uk/pdbe-srv/view/entry/2H09 PDBsum 2H09 http://www.ebi.ac.uk/pdbsum/2H09 PROSITE PS50944 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50944 PSORT swissprot:MNTR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MNTR_ECOLI PSORT-B swissprot:MNTR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MNTR_ECOLI PSORT2 swissprot:MNTR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MNTR_ECOLI Pfam PF01325 http://pfam.xfam.org/family/PF01325 Pfam PF02742 http://pfam.xfam.org/family/PF02742 Phobius swissprot:MNTR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MNTR_ECOLI PhylomeDB P0A9F1 http://phylomedb.org/?seqid=P0A9F1 ProteinModelPortal P0A9F1 http://www.proteinmodelportal.org/query/uniprot/P0A9F1 PubMed 11466284 http://www.ncbi.nlm.nih.gov/pubmed/11466284 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19701940 http://www.ncbi.nlm.nih.gov/pubmed/19701940 PubMed 21908668 http://www.ncbi.nlm.nih.gov/pubmed/21908668 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415338 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415338 RefSeq WP_000091016 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000091016 SMART SM00529 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00529 SMR P0A9F1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9F1 STRING 511145.b0817 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0817&targetmode=cogs STRING COG1321 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1321&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SUPFAM SSF47979 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47979 UniProtKB MNTR_ECOLI http://www.uniprot.org/uniprot/MNTR_ECOLI UniProtKB-AC P0A9F1 http://www.uniprot.org/uniprot/P0A9F1 charge swissprot:MNTR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MNTR_ECOLI eggNOG COG1321 http://eggnogapi.embl.de/nog_data/html/tree/COG1321 eggNOG ENOG4105KST http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KST epestfind swissprot:MNTR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MNTR_ECOLI garnier swissprot:MNTR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MNTR_ECOLI helixturnhelix swissprot:MNTR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MNTR_ECOLI hmoment swissprot:MNTR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MNTR_ECOLI iep swissprot:MNTR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MNTR_ECOLI inforesidue swissprot:MNTR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MNTR_ECOLI octanol swissprot:MNTR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MNTR_ECOLI pepcoil swissprot:MNTR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MNTR_ECOLI pepdigest swissprot:MNTR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MNTR_ECOLI pepinfo swissprot:MNTR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MNTR_ECOLI pepnet swissprot:MNTR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MNTR_ECOLI pepstats swissprot:MNTR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MNTR_ECOLI pepwheel swissprot:MNTR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MNTR_ECOLI pepwindow swissprot:MNTR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MNTR_ECOLI sigcleave swissprot:MNTR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MNTR_ECOLI ## Database ID URL or Descriptions # AltName NRDG_ECOLI Class III anaerobic ribonucleotide reductase small component # BioGrid 4259317 9 # COFACTOR Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI 49883; Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.; # EcoGene EG12523 nrdG # FUNCTION NRDG_ECOLI Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. # GO_component GO:0031250 anaerobic ribonucleoside-triphosphate reductase complex; IMP:EcoliWiki. # GO_function GO:0043365 [formate-C-acetyltransferase]-activating enzyme activity; IEA:InterPro. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051536 iron-sulfur cluster binding; IDA:EcoliWiki. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IDA:EcoCyc. # GO_process GO:0015949 nucleobase-containing small molecule interconversion; IMP:EcoliWiki. # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.70 -; 1. # INDUCTION Induced 2-fold by hydroxyurea. {ECO:0000269|PubMed 20005847}. # IntAct P0A9N8 4 # InterPro IPR001989 Radical_activat_CS # InterPro IPR012837 NrdG # InterPro IPR013785 Aldolase_TIM # KEGG_Brite ko01000 Enzymes # Organism NRDG_ECOLI Escherichia coli (strain K12) # PATRIC 32124047 VBIEscCol129921_4368 # PIR A55692 A55692 # PIRSF PIRSF000368 NrdG # PROSITE PS01087 RADICAL_ACTIVATING # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NRDG_ECOLI Anaerobic ribonucleoside-triphosphate reductase-activating protein # RefSeq NP_418658 NC_000913.3 # RefSeq WP_001106233 NZ_LN832404.1 # SIMILARITY Belongs to the organic radical-activating enzymes family. {ECO 0000305}. # SUBCELLULAR LOCATION NRDG_ECOLI Cytoplasm. # SUBUNIT NRDG_ECOLI Tetramer consisting of 2 alpha (NrdD) and 2 beta (NrdG) subunits. # TIGRFAMs TIGR02491 NrdG # eggNOG COG0602 LUCA # eggNOG ENOG4108RDD Bacteria BLAST swissprot:NRDG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NRDG_ECOLI BioCyc ECOL316407:JW4196-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4196-MONOMER BioCyc EcoCyc:RNTRACTIV-MONOMER http://biocyc.org/getid?id=EcoCyc:RNTRACTIV-MONOMER BioCyc MetaCyc:RNTRACTIV-MONOMER http://biocyc.org/getid?id=MetaCyc:RNTRACTIV-MONOMER COG COG0602 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0602 DIP DIP-48068N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48068N DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.270.6.2443 http://dx.doi.org/10.1074/jbc.270.6.2443 DOI 10.1074/jbc.275.21.15669 http://dx.doi.org/10.1074/jbc.275.21.15669 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.97.1.- http://www.genome.jp/dbget-bin/www_bget?EC:1.97.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL Z46865 http://www.ebi.ac.uk/ena/data/view/Z46865 ENZYME 1.97.1.- http://enzyme.expasy.org/EC/1.97.1.- EchoBASE EB2414 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2414 EcoGene EG12523 http://www.ecogene.org/geneInfo.php?eg_id=EG12523 EnsemblBacteria AAC77194 http://www.ensemblgenomes.org/id/AAC77194 EnsemblBacteria AAC77194 http://www.ensemblgenomes.org/id/AAC77194 EnsemblBacteria BAE78236 http://www.ensemblgenomes.org/id/BAE78236 EnsemblBacteria BAE78236 http://www.ensemblgenomes.org/id/BAE78236 EnsemblBacteria BAE78236 http://www.ensemblgenomes.org/id/BAE78236 EnsemblBacteria b4237 http://www.ensemblgenomes.org/id/b4237 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0031250 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031250 GO_function GO:0043365 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043365 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051536 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051536 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0015949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015949 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 948757 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948757 HOGENOM HOG000222587 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000222587&db=HOGENOM6 InParanoid P0A9N8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9N8 IntAct P0A9N8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9N8* IntEnz 1.97.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.97.1 InterPro IPR001989 http://www.ebi.ac.uk/interpro/entry/IPR001989 InterPro IPR012837 http://www.ebi.ac.uk/interpro/entry/IPR012837 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4196 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4196 KEGG_Gene eco:b4237 http://www.genome.jp/dbget-bin/www_bget?eco:b4237 KEGG_Orthology KO:K04068 http://www.genome.jp/dbget-bin/www_bget?KO:K04068 OMA QRVRAEC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QRVRAEC PROSITE PS01087 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01087 PSORT swissprot:NRDG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NRDG_ECOLI PSORT-B swissprot:NRDG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NRDG_ECOLI PSORT2 swissprot:NRDG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NRDG_ECOLI Phobius swissprot:NRDG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NRDG_ECOLI PhylomeDB P0A9N8 http://phylomedb.org/?seqid=P0A9N8 ProteinModelPortal P0A9N8 http://www.proteinmodelportal.org/query/uniprot/P0A9N8 PubMed 10821845 http://www.ncbi.nlm.nih.gov/pubmed/10821845 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 7852304 http://www.ncbi.nlm.nih.gov/pubmed/7852304 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418658 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418658 RefSeq WP_001106233 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001106233 STRING 511145.b4237 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4237&targetmode=cogs STRING COG0602 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0602&targetmode=cogs TIGRFAMs TIGR02491 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02491 UniProtKB NRDG_ECOLI http://www.uniprot.org/uniprot/NRDG_ECOLI UniProtKB-AC P0A9N8 http://www.uniprot.org/uniprot/P0A9N8 charge swissprot:NRDG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NRDG_ECOLI eggNOG COG0602 http://eggnogapi.embl.de/nog_data/html/tree/COG0602 eggNOG ENOG4108RDD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108RDD epestfind swissprot:NRDG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NRDG_ECOLI garnier swissprot:NRDG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NRDG_ECOLI helixturnhelix swissprot:NRDG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NRDG_ECOLI hmoment swissprot:NRDG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NRDG_ECOLI iep swissprot:NRDG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NRDG_ECOLI inforesidue swissprot:NRDG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NRDG_ECOLI octanol swissprot:NRDG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NRDG_ECOLI pepcoil swissprot:NRDG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NRDG_ECOLI pepdigest swissprot:NRDG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NRDG_ECOLI pepinfo swissprot:NRDG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NRDG_ECOLI pepnet swissprot:NRDG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NRDG_ECOLI pepstats swissprot:NRDG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NRDG_ECOLI pepwheel swissprot:NRDG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NRDG_ECOLI pepwindow swissprot:NRDG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NRDG_ECOLI sigcleave swissprot:NRDG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NRDG_ECOLI ## Database ID URL or Descriptions # EcoGene EG14238 ylaC # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR019713 Memb_YlaC # Organism YLAC_ECOLI Escherichia coli (strain K12) # PATRIC 32116069 VBIEscCol129921_0476 # PIR A64776 A64776 # Pfam PF10777 YlaC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YLAC_ECOLI Inner membrane protein YlaC # RefSeq NP_414991 NC_000913.3 # RefSeq WP_000136192 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40213.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SUBCELLULAR LOCATION YLAC_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG ENOG4105GSJ Bacteria # eggNOG ENOG4111PQG LUCA BLAST swissprot:YLAC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YLAC_ECOLI BioCyc ECOL316407:JW5063-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5063-MONOMER BioCyc EcoCyc:G6253-MONOMER http://biocyc.org/getid?id=EcoCyc:G6253-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EchoBASE EB3989 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3989 EcoGene EG14238 http://www.ecogene.org/geneInfo.php?eg_id=EG14238 EnsemblBacteria AAC73560 http://www.ensemblgenomes.org/id/AAC73560 EnsemblBacteria AAC73560 http://www.ensemblgenomes.org/id/AAC73560 EnsemblBacteria BAE76237 http://www.ensemblgenomes.org/id/BAE76237 EnsemblBacteria BAE76237 http://www.ensemblgenomes.org/id/BAE76237 EnsemblBacteria BAE76237 http://www.ensemblgenomes.org/id/BAE76237 EnsemblBacteria b0458 http://www.ensemblgenomes.org/id/b0458 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 948876 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948876 HOGENOM HOG000117611 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117611&db=HOGENOM6 InterPro IPR019713 http://www.ebi.ac.uk/interpro/entry/IPR019713 KEGG_Gene ecj:JW5063 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5063 KEGG_Gene eco:b0458 http://www.genome.jp/dbget-bin/www_bget?eco:b0458 OMA VDFYDVY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VDFYDVY PSORT swissprot:YLAC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YLAC_ECOLI PSORT-B swissprot:YLAC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YLAC_ECOLI PSORT2 swissprot:YLAC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YLAC_ECOLI Pfam PF10777 http://pfam.xfam.org/family/PF10777 Phobius swissprot:YLAC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YLAC_ECOLI ProteinModelPortal P0AAS0 http://www.proteinmodelportal.org/query/uniprot/P0AAS0 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414991 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414991 RefSeq WP_000136192 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000136192 STRING 511145.b0458 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0458&targetmode=cogs UniProtKB YLAC_ECOLI http://www.uniprot.org/uniprot/YLAC_ECOLI UniProtKB-AC P0AAS0 http://www.uniprot.org/uniprot/P0AAS0 charge swissprot:YLAC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YLAC_ECOLI eggNOG ENOG4105GSJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105GSJ eggNOG ENOG4111PQG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111PQG epestfind swissprot:YLAC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YLAC_ECOLI garnier swissprot:YLAC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YLAC_ECOLI helixturnhelix swissprot:YLAC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YLAC_ECOLI hmoment swissprot:YLAC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YLAC_ECOLI iep swissprot:YLAC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YLAC_ECOLI inforesidue swissprot:YLAC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YLAC_ECOLI octanol swissprot:YLAC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YLAC_ECOLI pepcoil swissprot:YLAC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YLAC_ECOLI pepdigest swissprot:YLAC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YLAC_ECOLI pepinfo swissprot:YLAC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YLAC_ECOLI pepnet swissprot:YLAC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YLAC_ECOLI pepstats swissprot:YLAC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YLAC_ECOLI pepwheel swissprot:YLAC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YLAC_ECOLI pepwindow swissprot:YLAC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YLAC_ECOLI sigcleave swissprot:YLAC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YLAC_ECOLI ## Database ID URL or Descriptions # AltName HSCC_ECOLI Hsc62 # BioGrid 4263357 10 # EcoGene EG13653 hscC # FUNCTION HSCC_ECOLI Probable chaperone. Has ATPase activity. Not stimulated by DnaJ. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016887 ATPase activity; IDA:EcoCyc. # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # Gene3D 2.60.34.10 -; 1. # INDUCTION HSCC_ECOLI By heat shock. Activated up to a temperature of 40 degrees Celsius, after which levels decrease. # IntAct P77319 33 # InterPro IPR013126 Hsp_70_fam # InterPro IPR018181 Heat_shock_70_CS # InterPro IPR029047 HSP70_peptide-bd # KEGG_Brite ko02000 Transporters # KEGG_Brite ko03110 Chaperones and folding catalysts # Organism HSCC_ECOLI Escherichia coli (strain K12) # PATRIC 32116483 VBIEscCol129921_0681 # PIR H64799 H64799 # PRINTS PR00301 HEATSHOCK70 # PROSITE PS00297 HSP70_1 # PROSITE PS00329 HSP70_2 # PROSITE PS01036 HSP70_3 # Pfam PF00012 HSP70 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HSCC_ECOLI Chaperone protein HscC # RefSeq NP_415183 NC_000913.3 # RefSeq WP_000367875 NZ_LN832404.1 # SIMILARITY Belongs to the heat shock protein 70 family. {ECO 0000305}. # SUPFAM SSF100920 SSF100920 # eggNOG COG0443 LUCA # eggNOG ENOG4105F7F Bacteria BLAST swissprot:HSCC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HSCC_ECOLI BioCyc ECOL316407:JW0645-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0645-MONOMER BioCyc EcoCyc:G6357-MONOMER http://biocyc.org/getid?id=EcoCyc:G6357-MONOMER COG COG0443 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0443 DIP DIP-9942N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9942N DOI 10.1006/bbrc.1998.9255 http://dx.doi.org/10.1006/bbrc.1998.9255 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB3417 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3417 EcoGene EG13653 http://www.ecogene.org/geneInfo.php?eg_id=EG13653 EnsemblBacteria AAC73751 http://www.ensemblgenomes.org/id/AAC73751 EnsemblBacteria AAC73751 http://www.ensemblgenomes.org/id/AAC73751 EnsemblBacteria BAA35297 http://www.ensemblgenomes.org/id/BAA35297 EnsemblBacteria BAA35297 http://www.ensemblgenomes.org/id/BAA35297 EnsemblBacteria BAA35297 http://www.ensemblgenomes.org/id/BAA35297 EnsemblBacteria b0650 http://www.ensemblgenomes.org/id/b0650 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 2.60.34.10 http://www.cathdb.info/version/latest/superfamily/2.60.34.10 GeneID 945218 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945218 HOGENOM HOG000228137 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000228137&db=HOGENOM6 InParanoid P77319 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77319 IntAct P77319 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77319* InterPro IPR013126 http://www.ebi.ac.uk/interpro/entry/IPR013126 InterPro IPR018181 http://www.ebi.ac.uk/interpro/entry/IPR018181 InterPro IPR029047 http://www.ebi.ac.uk/interpro/entry/IPR029047 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW0645 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0645 KEGG_Gene eco:b0650 http://www.genome.jp/dbget-bin/www_bget?eco:b0650 KEGG_Orthology KO:K04045 http://www.genome.jp/dbget-bin/www_bget?KO:K04045 OMA REEDWRI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=REEDWRI PRINTS PR00301 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00301 PROSITE PS00297 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00297 PROSITE PS00329 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00329 PROSITE PS01036 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01036 PSORT swissprot:HSCC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HSCC_ECOLI PSORT-B swissprot:HSCC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HSCC_ECOLI PSORT2 swissprot:HSCC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HSCC_ECOLI Pfam PF00012 http://pfam.xfam.org/family/PF00012 Phobius swissprot:HSCC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HSCC_ECOLI PhylomeDB P77319 http://phylomedb.org/?seqid=P77319 ProteinModelPortal P77319 http://www.proteinmodelportal.org/query/uniprot/P77319 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9735342 http://www.ncbi.nlm.nih.gov/pubmed/9735342 RefSeq NP_415183 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415183 RefSeq WP_000367875 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000367875 SMR P77319 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77319 STRING 511145.b0650 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0650&targetmode=cogs STRING COG0443 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0443&targetmode=cogs SUPFAM SSF100920 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF100920 UniProtKB HSCC_ECOLI http://www.uniprot.org/uniprot/HSCC_ECOLI UniProtKB-AC P77319 http://www.uniprot.org/uniprot/P77319 charge swissprot:HSCC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HSCC_ECOLI eggNOG COG0443 http://eggnogapi.embl.de/nog_data/html/tree/COG0443 eggNOG ENOG4105F7F http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F7F epestfind swissprot:HSCC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HSCC_ECOLI garnier swissprot:HSCC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HSCC_ECOLI helixturnhelix swissprot:HSCC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HSCC_ECOLI hmoment swissprot:HSCC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HSCC_ECOLI iep swissprot:HSCC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HSCC_ECOLI inforesidue swissprot:HSCC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HSCC_ECOLI octanol swissprot:HSCC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HSCC_ECOLI pepcoil swissprot:HSCC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HSCC_ECOLI pepdigest swissprot:HSCC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HSCC_ECOLI pepinfo swissprot:HSCC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HSCC_ECOLI pepnet swissprot:HSCC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HSCC_ECOLI pepstats swissprot:HSCC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HSCC_ECOLI pepwheel swissprot:HSCC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HSCC_ECOLI pepwindow swissprot:HSCC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HSCC_ECOLI sigcleave swissprot:HSCC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HSCC_ECOLI ## Database ID URL or Descriptions # BioGrid 4259693 2 # EcoGene EG14053 yegJ # InterPro IPR018756 DUF2314 # Organism YEGJ_ECOLI Escherichia coli (strain K12) # PATRIC 32119475 VBIEscCol129921_2148 # PIR F64973 F64973 # Pfam PF10077 DUF2314 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEGJ_ECOLI Uncharacterized protein YegJ # RefSeq NP_416575 NC_000913.3 # RefSeq WP_000722348 NZ_LN832404.1 # eggNOG COG3779 LUCA # eggNOG ENOG4105ZD5 Bacteria BLAST swissprot:YEGJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEGJ_ECOLI BioCyc ECOL316407:JW2056-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2056-MONOMER BioCyc EcoCyc:G7110-MONOMER http://biocyc.org/getid?id=EcoCyc:G7110-MONOMER DIP DIP-11880N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11880N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3806 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3806 EcoGene EG14053 http://www.ecogene.org/geneInfo.php?eg_id=EG14053 EnsemblBacteria AAC75132 http://www.ensemblgenomes.org/id/AAC75132 EnsemblBacteria AAC75132 http://www.ensemblgenomes.org/id/AAC75132 EnsemblBacteria BAE76578 http://www.ensemblgenomes.org/id/BAE76578 EnsemblBacteria BAE76578 http://www.ensemblgenomes.org/id/BAE76578 EnsemblBacteria BAE76578 http://www.ensemblgenomes.org/id/BAE76578 EnsemblBacteria b2071 http://www.ensemblgenomes.org/id/b2071 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947201 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947201 HOGENOM HOG000009749 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009749&db=HOGENOM6 InParanoid P76394 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76394 IntAct P76394 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76394* InterPro IPR018756 http://www.ebi.ac.uk/interpro/entry/IPR018756 KEGG_Gene ecj:JW2056 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2056 KEGG_Gene eco:b2071 http://www.genome.jp/dbget-bin/www_bget?eco:b2071 OMA AKAHEKS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AKAHEKS PSORT swissprot:YEGJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEGJ_ECOLI PSORT-B swissprot:YEGJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEGJ_ECOLI PSORT2 swissprot:YEGJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEGJ_ECOLI Pfam PF10077 http://pfam.xfam.org/family/PF10077 Phobius swissprot:YEGJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEGJ_ECOLI PhylomeDB P76394 http://phylomedb.org/?seqid=P76394 ProteinModelPortal P76394 http://www.proteinmodelportal.org/query/uniprot/P76394 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416575 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416575 RefSeq WP_000722348 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000722348 STRING 511145.b2071 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2071&targetmode=cogs UniProtKB YEGJ_ECOLI http://www.uniprot.org/uniprot/YEGJ_ECOLI UniProtKB-AC P76394 http://www.uniprot.org/uniprot/P76394 charge swissprot:YEGJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEGJ_ECOLI eggNOG COG3779 http://eggnogapi.embl.de/nog_data/html/tree/COG3779 eggNOG ENOG4105ZD5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ZD5 epestfind swissprot:YEGJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEGJ_ECOLI garnier swissprot:YEGJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEGJ_ECOLI helixturnhelix swissprot:YEGJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEGJ_ECOLI hmoment swissprot:YEGJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEGJ_ECOLI iep swissprot:YEGJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEGJ_ECOLI inforesidue swissprot:YEGJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEGJ_ECOLI octanol swissprot:YEGJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEGJ_ECOLI pepcoil swissprot:YEGJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEGJ_ECOLI pepdigest swissprot:YEGJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEGJ_ECOLI pepinfo swissprot:YEGJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEGJ_ECOLI pepnet swissprot:YEGJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEGJ_ECOLI pepstats swissprot:YEGJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEGJ_ECOLI pepwheel swissprot:YEGJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEGJ_ECOLI pepwindow swissprot:YEGJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEGJ_ECOLI sigcleave swissprot:YEGJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEGJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4263053 11 # EcoGene EG13712 elfG # FUNCTION ELFG_ECOLI Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. {ECO 0000269|PubMed 20345943}. # GO_component GO:0009289 pilus; IEA:UniProtKB-SubCell. # GO_process GO:0043709 cell adhesion involved in single-species biofilm formation; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0007155 cell adhesion # Gene3D 2.60.40.1090 -; 1. # INDUCTION Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression. {ECO:0000269|PubMed 20345943}. # InterPro IPR000259 Adhesion_dom_fimbrial # InterPro IPR008966 Adhesion_dom # MISCELLANEOUS The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed. {ECO:0000305|PubMed 20345943}. # Organism ELFG_ECOLI Escherichia coli (strain K12) # PATRIC 32117101 VBIEscCol129921_0975 # PIR D64834 D64834 # Pfam PF00419 Fimbrial # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ELFG_ECOLI Uncharacterized fimbrial-like protein ElfG # RefSeq NP_415461 NC_000913.3 # RefSeq WP_001165668 NZ_LN832404.1 # SIMILARITY Belongs to the fimbrial protein family. {ECO 0000305}. # SUBCELLULAR LOCATION ELFG_ECOLI Fimbrium {ECO 0000305}. # SUPFAM SSF49401 SSF49401 # eggNOG COG3539 LUCA # eggNOG ENOG4108MDY Bacteria BLAST swissprot:ELFG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ELFG_ECOLI BioCyc ECOL316407:JW0924-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0924-MONOMER BioCyc EcoCyc:G6483-MONOMER http://biocyc.org/getid?id=EcoCyc:G6483-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1462-2920.2010.02202.x http://dx.doi.org/10.1111/j.1462-2920.2010.02202.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3476 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3476 EcoGene EG13712 http://www.ecogene.org/geneInfo.php?eg_id=EG13712 EnsemblBacteria AAC74027 http://www.ensemblgenomes.org/id/AAC74027 EnsemblBacteria AAC74027 http://www.ensemblgenomes.org/id/AAC74027 EnsemblBacteria BAA35696 http://www.ensemblgenomes.org/id/BAA35696 EnsemblBacteria BAA35696 http://www.ensemblgenomes.org/id/BAA35696 EnsemblBacteria BAA35696 http://www.ensemblgenomes.org/id/BAA35696 EnsemblBacteria b0941 http://www.ensemblgenomes.org/id/b0941 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009289 GO_process GO:0043709 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043709 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 Gene3D 2.60.40.1090 http://www.cathdb.info/version/latest/superfamily/2.60.40.1090 GeneID 947185 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947185 HOGENOM HOG000009398 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009398&db=HOGENOM6 InterPro IPR000259 http://www.ebi.ac.uk/interpro/entry/IPR000259 InterPro IPR008966 http://www.ebi.ac.uk/interpro/entry/IPR008966 KEGG_Gene ecj:JW0924 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0924 KEGG_Gene eco:b0941 http://www.genome.jp/dbget-bin/www_bget?eco:b0941 OMA CYNIPAS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CYNIPAS PSORT swissprot:ELFG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ELFG_ECOLI PSORT-B swissprot:ELFG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ELFG_ECOLI PSORT2 swissprot:ELFG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ELFG_ECOLI Pfam PF00419 http://pfam.xfam.org/family/PF00419 Phobius swissprot:ELFG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ELFG_ECOLI PhylomeDB P75858 http://phylomedb.org/?seqid=P75858 ProteinModelPortal P75858 http://www.proteinmodelportal.org/query/uniprot/P75858 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20345943 http://www.ncbi.nlm.nih.gov/pubmed/20345943 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415461 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415461 RefSeq WP_001165668 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001165668 SMR P75858 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75858 STRING 511145.b0941 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0941&targetmode=cogs SUPFAM SSF49401 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49401 UniProtKB ELFG_ECOLI http://www.uniprot.org/uniprot/ELFG_ECOLI UniProtKB-AC P75858 http://www.uniprot.org/uniprot/P75858 charge swissprot:ELFG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ELFG_ECOLI eggNOG COG3539 http://eggnogapi.embl.de/nog_data/html/tree/COG3539 eggNOG ENOG4108MDY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MDY epestfind swissprot:ELFG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ELFG_ECOLI garnier swissprot:ELFG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ELFG_ECOLI helixturnhelix swissprot:ELFG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ELFG_ECOLI hmoment swissprot:ELFG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ELFG_ECOLI iep swissprot:ELFG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ELFG_ECOLI inforesidue swissprot:ELFG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ELFG_ECOLI octanol swissprot:ELFG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ELFG_ECOLI pepcoil swissprot:ELFG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ELFG_ECOLI pepdigest swissprot:ELFG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ELFG_ECOLI pepinfo swissprot:ELFG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ELFG_ECOLI pepnet swissprot:ELFG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ELFG_ECOLI pepstats swissprot:ELFG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ELFG_ECOLI pepwheel swissprot:ELFG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ELFG_ECOLI pepwindow swissprot:ELFG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ELFG_ECOLI sigcleave swissprot:ELFG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ELFG_ECOLI ## Database ID URL or Descriptions # BioGrid 4263143 2 # EcoGene EG12315 yacH # IntAct P36682 7 # InterPro IPR021728 DUF3300 # Organism YACH_ECOLI Escherichia coli (strain K12) # PATRIC 32115335 VBIEscCol129921_0119 # PIR E64734 E64734 # Pfam PF11737 DUF3300 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YACH_ECOLI Uncharacterized protein YacH # RefSeq NP_414659 NC_000913.3 # RefSeq WP_000784470 NZ_LN832404.1 # eggNOG ENOG4108NST Bacteria # eggNOG ENOG410ZJQ8 LUCA BLAST swissprot:YACH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YACH_ECOLI BioCyc ECOL316407:JW0113-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0113-MONOMER BioCyc EcoCyc:EG12315-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12315-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2221 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2221 EcoGene EG12315 http://www.ecogene.org/geneInfo.php?eg_id=EG12315 EnsemblBacteria AAC73228 http://www.ensemblgenomes.org/id/AAC73228 EnsemblBacteria AAC73228 http://www.ensemblgenomes.org/id/AAC73228 EnsemblBacteria BAB96689 http://www.ensemblgenomes.org/id/BAB96689 EnsemblBacteria BAB96689 http://www.ensemblgenomes.org/id/BAB96689 EnsemblBacteria BAB96689 http://www.ensemblgenomes.org/id/BAB96689 EnsemblBacteria b0117 http://www.ensemblgenomes.org/id/b0117 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 944868 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944868 HOGENOM HOG000013077 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000013077&db=HOGENOM6 InParanoid P36682 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P36682 IntAct P36682 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P36682* InterPro IPR021728 http://www.ebi.ac.uk/interpro/entry/IPR021728 KEGG_Gene ecj:JW0113 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0113 KEGG_Gene eco:b0117 http://www.genome.jp/dbget-bin/www_bget?eco:b0117 OMA QWVAPIA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QWVAPIA PSORT swissprot:YACH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YACH_ECOLI PSORT-B swissprot:YACH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YACH_ECOLI PSORT2 swissprot:YACH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YACH_ECOLI Pfam PF11737 http://pfam.xfam.org/family/PF11737 Phobius swissprot:YACH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YACH_ECOLI PhylomeDB P36682 http://phylomedb.org/?seqid=P36682 ProteinModelPortal P36682 http://www.proteinmodelportal.org/query/uniprot/P36682 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414659 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414659 RefSeq WP_000784470 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000784470 STRING 511145.b0117 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0117&targetmode=cogs UniProtKB YACH_ECOLI http://www.uniprot.org/uniprot/YACH_ECOLI UniProtKB-AC P36682 http://www.uniprot.org/uniprot/P36682 charge swissprot:YACH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YACH_ECOLI eggNOG ENOG4108NST http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108NST eggNOG ENOG410ZJQ8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZJQ8 epestfind swissprot:YACH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YACH_ECOLI garnier swissprot:YACH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YACH_ECOLI helixturnhelix swissprot:YACH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YACH_ECOLI hmoment swissprot:YACH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YACH_ECOLI iep swissprot:YACH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YACH_ECOLI inforesidue swissprot:YACH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YACH_ECOLI octanol swissprot:YACH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YACH_ECOLI pepcoil swissprot:YACH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YACH_ECOLI pepdigest swissprot:YACH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YACH_ECOLI pepinfo swissprot:YACH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YACH_ECOLI pepnet swissprot:YACH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YACH_ECOLI pepstats swissprot:YACH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YACH_ECOLI pepwheel swissprot:YACH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YACH_ECOLI pepwindow swissprot:YACH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YACH_ECOLI sigcleave swissprot:YACH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YACH_ECOLI ## Database ID URL or Descriptions # BioGrid 4259997 7 # CDD cd06261 TM_PBP2 # EcoGene EG11626 artQ # FUNCTION ARTQ_ECOLI Part of the ABC transporter complex ArtPIQMJ involved in arginine transport. Probably responsible for the translocation of the substrate across the membrane. {ECO 0000269|PubMed 8801422}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; ISM:EcoCyc. # GO_function GO:0005215 transporter activity; IEA:InterPro. # GO_process GO:1902765 L-arginine import into cell; ISO:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006810 transport # Gene3D 1.10.3720.10 -; 1. # InterPro IPR000515 MetI-like # InterPro IPR010065 AA_ABC_transptr_permease_3TM # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00229 Arginine transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism ARTQ_ECOLI Escherichia coli (strain K12) # PATRIC 32116931 VBIEscCol129921_0891 # PIR F64824 F64824 # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ARTQ_ECOLI Arginine ABC transporter permease protein ArtQ # RefSeq NP_415383 NC_000913.3 # RefSeq WP_001001691 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION ARTQ_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT The complex is composed of two ATP-binding proteins (ArtP), two transmembrane proteins (ArtM and ArtQ) and two solute- binding proteins (ArtJ and ArtI). {ECO:0000305|PubMed 8801422}. # SUPFAM SSF161098 SSF161098 # TCDB 3.A.1.3 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR01726 HEQRo_perm_3TM # eggNOG COG4215 LUCA # eggNOG ENOG4105GBT Bacteria BLAST swissprot:ARTQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARTQ_ECOLI BioCyc ECOL316407:JW0846-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0846-MONOMER BioCyc EcoCyc:ARTQ-MONOMER http://biocyc.org/getid?id=EcoCyc:ARTQ-MONOMER BioCyc MetaCyc:ARTQ-MONOMER http://biocyc.org/getid?id=MetaCyc:ARTQ-MONOMER COG COG4215 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4215 DIP DIP-48128N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48128N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1995.mmi_17040675.x http://dx.doi.org/10.1111/j.1365-2958.1995.mmi_17040675.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X86160 http://www.ebi.ac.uk/ena/data/view/X86160 EchoBASE EB1583 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1583 EcoGene EG11626 http://www.ecogene.org/geneInfo.php?eg_id=EG11626 EnsemblBacteria AAC73949 http://www.ensemblgenomes.org/id/AAC73949 EnsemblBacteria AAC73949 http://www.ensemblgenomes.org/id/AAC73949 EnsemblBacteria BAA35576 http://www.ensemblgenomes.org/id/BAA35576 EnsemblBacteria BAA35576 http://www.ensemblgenomes.org/id/BAA35576 EnsemblBacteria BAA35576 http://www.ensemblgenomes.org/id/BAA35576 EnsemblBacteria b0862 http://www.ensemblgenomes.org/id/b0862 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_process GO:1902765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902765 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 949046 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949046 HOGENOM HOG000267551 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267551&db=HOGENOM6 InParanoid P0AE34 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AE34 IntAct P0AE34 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AE34* InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 InterPro IPR010065 http://www.ebi.ac.uk/interpro/entry/IPR010065 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0846 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0846 KEGG_Gene eco:b0862 http://www.genome.jp/dbget-bin/www_bget?eco:b0862 KEGG_Orthology KO:K09999 http://www.genome.jp/dbget-bin/www_bget?KO:K09999 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 MINT MINT-1257390 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1257390 OMA QASWMTV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QASWMTV PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:ARTQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARTQ_ECOLI PSORT-B swissprot:ARTQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARTQ_ECOLI PSORT2 swissprot:ARTQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARTQ_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Phobius swissprot:ARTQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARTQ_ECOLI PhylomeDB P0AE34 http://phylomedb.org/?seqid=P0AE34 ProteinModelPortal P0AE34 http://www.proteinmodelportal.org/query/uniprot/P0AE34 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8501075 http://www.ncbi.nlm.nih.gov/pubmed/8501075 PubMed 8801422 http://www.ncbi.nlm.nih.gov/pubmed/8801422 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415383 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415383 RefSeq WP_001001691 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001001691 STRING 511145.b0862 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0862&targetmode=cogs STRING COG4215 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4215&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.3 http://www.tcdb.org/search/result.php?tc=3.A.1.3 TIGRFAMs TIGR01726 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01726 UniProtKB ARTQ_ECOLI http://www.uniprot.org/uniprot/ARTQ_ECOLI UniProtKB-AC P0AE34 http://www.uniprot.org/uniprot/P0AE34 charge swissprot:ARTQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARTQ_ECOLI eggNOG COG4215 http://eggnogapi.embl.de/nog_data/html/tree/COG4215 eggNOG ENOG4105GBT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105GBT epestfind swissprot:ARTQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARTQ_ECOLI garnier swissprot:ARTQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARTQ_ECOLI helixturnhelix swissprot:ARTQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARTQ_ECOLI hmoment swissprot:ARTQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARTQ_ECOLI iep swissprot:ARTQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARTQ_ECOLI inforesidue swissprot:ARTQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARTQ_ECOLI octanol swissprot:ARTQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARTQ_ECOLI pepcoil swissprot:ARTQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARTQ_ECOLI pepdigest swissprot:ARTQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARTQ_ECOLI pepinfo swissprot:ARTQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARTQ_ECOLI pepnet swissprot:ARTQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARTQ_ECOLI pepstats swissprot:ARTQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARTQ_ECOLI pepwheel swissprot:ARTQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARTQ_ECOLI pepwindow swissprot:ARTQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARTQ_ECOLI sigcleave swissprot:ARTQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARTQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4262096 13 # EcoGene EG12229 yhiN # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0016491 oxidoreductase activity; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # Gene3D 1.10.8.260 -; 1. # Gene3D 3.50.50.60 -; 2. # IntAct P37631 11 # InterPro IPR004792 CHP00275_HI0933-like # InterPro IPR023166 HI0933_dom # InterPro IPR023753 FAD/NAD-binding_dom # Organism YHIN_ECOLI Escherichia coli (strain K12) # PATRIC 32122432 VBIEscCol129921_3593 # PIR G65146 G65146 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHIN_ECOLI Uncharacterized protein YhiN # RefSeq NP_417949 NC_000913.3 # RefSeq WP_000439170 NZ_LN832404.1 # SIMILARITY To H.influenzae HI_0933. {ECO 0000305}. # SUPFAM SSF51905 SSF51905; 2 # TIGRFAMs TIGR00275 TIGR00275 # eggNOG COG2081 LUCA # eggNOG ENOG4105CBX Bacteria BLAST swissprot:YHIN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHIN_ECOLI BioCyc ECOL316407:JW3459-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3459-MONOMER BioCyc EcoCyc:EG12229-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12229-MONOMER COG COG2081 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2081 DIP DIP-12368N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12368N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2141 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2141 EcoGene EG12229 http://www.ecogene.org/geneInfo.php?eg_id=EG12229 EnsemblBacteria AAC76517 http://www.ensemblgenomes.org/id/AAC76517 EnsemblBacteria AAC76517 http://www.ensemblgenomes.org/id/AAC76517 EnsemblBacteria BAE77802 http://www.ensemblgenomes.org/id/BAE77802 EnsemblBacteria BAE77802 http://www.ensemblgenomes.org/id/BAE77802 EnsemblBacteria BAE77802 http://www.ensemblgenomes.org/id/BAE77802 EnsemblBacteria b3492 http://www.ensemblgenomes.org/id/b3492 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 Gene3D 1.10.8.260 http://www.cathdb.info/version/latest/superfamily/1.10.8.260 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 GeneID 947996 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947996 HOGENOM HOG000043046 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000043046&db=HOGENOM6 InParanoid P37631 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37631 IntAct P37631 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37631* InterPro IPR004792 http://www.ebi.ac.uk/interpro/entry/IPR004792 InterPro IPR023166 http://www.ebi.ac.uk/interpro/entry/IPR023166 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 KEGG_Gene ecj:JW3459 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3459 KEGG_Gene eco:b3492 http://www.genome.jp/dbget-bin/www_bget?eco:b3492 KEGG_Orthology KO:K07007 http://www.genome.jp/dbget-bin/www_bget?KO:K07007 OMA RCNFTNM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RCNFTNM PSORT swissprot:YHIN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHIN_ECOLI PSORT-B swissprot:YHIN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHIN_ECOLI PSORT2 swissprot:YHIN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHIN_ECOLI Phobius swissprot:YHIN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHIN_ECOLI PhylomeDB P37631 http://phylomedb.org/?seqid=P37631 ProteinModelPortal P37631 http://www.proteinmodelportal.org/query/uniprot/P37631 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417949 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417949 RefSeq WP_000439170 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000439170 SMR P37631 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37631 STRING 511145.b3492 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3492&targetmode=cogs STRING COG2081 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2081&targetmode=cogs SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 TIGRFAMs TIGR00275 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00275 UniProtKB YHIN_ECOLI http://www.uniprot.org/uniprot/YHIN_ECOLI UniProtKB-AC P37631 http://www.uniprot.org/uniprot/P37631 charge swissprot:YHIN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHIN_ECOLI eggNOG COG2081 http://eggnogapi.embl.de/nog_data/html/tree/COG2081 eggNOG ENOG4105CBX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CBX epestfind swissprot:YHIN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHIN_ECOLI garnier swissprot:YHIN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHIN_ECOLI helixturnhelix swissprot:YHIN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHIN_ECOLI hmoment swissprot:YHIN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHIN_ECOLI iep swissprot:YHIN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHIN_ECOLI inforesidue swissprot:YHIN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHIN_ECOLI octanol swissprot:YHIN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHIN_ECOLI pepcoil swissprot:YHIN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHIN_ECOLI pepdigest swissprot:YHIN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHIN_ECOLI pepinfo swissprot:YHIN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHIN_ECOLI pepnet swissprot:YHIN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHIN_ECOLI pepstats swissprot:YHIN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHIN_ECOLI pepwheel swissprot:YHIN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHIN_ECOLI pepwindow swissprot:YHIN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHIN_ECOLI sigcleave swissprot:YHIN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHIN_ECOLI ## Database ID URL or Descriptions # BioGrid 4262383 229 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG14228 yqiG # FUNCTION YQIG_ECOLI Involved in the export and assembly of a fimbrial subunit across the outer membrane. {ECO 0000250}. # GO_component GO:0009279 cell outer membrane; IBA:GO_Central. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015473 fimbrial usher porin activity; IBA:GO_Central. # GO_process GO:0009297 pilus assembly; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0022607 cellular component assembly # InterPro IPR000015 Fimb_usher # InterPro IPR018030 Fimbrial_membr_usher_CS # InterPro IPR025885 PapC_N # InterPro IPR025949 PapC-like_C # Organism YQIG_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30451 PTHR30451 # PATRIC 48665534 VBIEscCol107702_3075 # PIR D65092 D65092 # PROSITE PS01151 FIMBRIAL_USHER # Pfam PF00577 Usher # Pfam PF13953 PapC_C # Pfam PF13954 PapC_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQIG_ECOLI Putative outer membrane usher protein YqiG # RefSeq WP_000016375 NZ_LN832404.1 # SIMILARITY Belongs to the fimbrial export usher family. {ECO 0000305}. # SUBCELLULAR LOCATION YQIG_ECOLI Cell outer membrane {ECO 0000250}; Multi- pass membrane protein {ECO 0000250}. BLAST swissprot:YQIG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQIG_ECOLI BioCyc ECOL316407:JW5507-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5507-MONOMER BioCyc EcoCyc:G7585-MONOMER http://biocyc.org/getid?id=EcoCyc:G7585-MONOMER DIP DIP-12877N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12877N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3979 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3979 EcoGene EG14228 http://www.ecogene.org/geneInfo.php?eg_id=EG14228 EnsemblBacteria BAA16575 http://www.ensemblgenomes.org/id/BAA16575 EnsemblBacteria BAA16575 http://www.ensemblgenomes.org/id/BAA16575 EnsemblBacteria BAA16575 http://www.ensemblgenomes.org/id/BAA16575 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015473 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015473 GO_process GO:0009297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009297 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 InParanoid P76655 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76655 InterPro IPR000015 http://www.ebi.ac.uk/interpro/entry/IPR000015 InterPro IPR018030 http://www.ebi.ac.uk/interpro/entry/IPR018030 InterPro IPR025885 http://www.ebi.ac.uk/interpro/entry/IPR025885 InterPro IPR025949 http://www.ebi.ac.uk/interpro/entry/IPR025949 KEGG_Gene ecj:JW5507 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5507 OMA RANYAKR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RANYAKR PANTHER PTHR30451 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30451 PROSITE PS01151 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01151 PSORT swissprot:YQIG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQIG_ECOLI PSORT-B swissprot:YQIG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQIG_ECOLI PSORT2 swissprot:YQIG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQIG_ECOLI Pfam PF00577 http://pfam.xfam.org/family/PF00577 Pfam PF13953 http://pfam.xfam.org/family/PF13953 Pfam PF13954 http://pfam.xfam.org/family/PF13954 Phobius swissprot:YQIG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQIG_ECOLI PhylomeDB P76655 http://phylomedb.org/?seqid=P76655 ProteinModelPortal P76655 http://www.proteinmodelportal.org/query/uniprot/P76655 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000016375 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000016375 SMR P76655 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76655 STRING 316407.85675849 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85675849&targetmode=cogs UniProtKB YQIG_ECOLI http://www.uniprot.org/uniprot/YQIG_ECOLI UniProtKB-AC P76655 http://www.uniprot.org/uniprot/P76655 charge swissprot:YQIG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQIG_ECOLI epestfind swissprot:YQIG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQIG_ECOLI garnier swissprot:YQIG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQIG_ECOLI helixturnhelix swissprot:YQIG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQIG_ECOLI hmoment swissprot:YQIG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQIG_ECOLI iep swissprot:YQIG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQIG_ECOLI inforesidue swissprot:YQIG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQIG_ECOLI octanol swissprot:YQIG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQIG_ECOLI pepcoil swissprot:YQIG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQIG_ECOLI pepdigest swissprot:YQIG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQIG_ECOLI pepinfo swissprot:YQIG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQIG_ECOLI pepnet swissprot:YQIG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQIG_ECOLI pepstats swissprot:YQIG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQIG_ECOLI pepwheel swissprot:YQIG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQIG_ECOLI pepwindow swissprot:YQIG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQIG_ECOLI sigcleave swissprot:YQIG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQIG_ECOLI ## Database ID URL or Descriptions # AltName FDOH_ECOLI Aerobic formate dehydrogenase iron-sulfur subunit # AltName FDOH_ECOLI FDH-Z subunit beta # AltName FDOH_ECOLI Formate dehydrogenase-O subunit beta # BioGrid 4263325 18 # COFACTOR FDOH_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000250}; Note=Binds 4 [4Fe-4S] clusters per subunit. {ECO 0000250}; # EcoGene EG11857 fdoH # FUNCTION FDOH_ECOLI Allows to use formate as major electron donor during aerobic respiration. The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron- sulfur centers. Electrons are transferred from the gamma chain to the molybdenum cofactor of the alpha subunit (By similarity). {ECO 0000250}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_component GO:0009326 formate dehydrogenase complex; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_component GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane; IDA:EcoCyc. # GO_function GO:0036397 formate dehydrogenase (quinone) activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0015944 formate oxidation; IDA:EcoCyc. # GO_process GO:0045333 cellular respiration; IEP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0044281 small molecule metabolic process # IntAct P0AAJ5 4 # InterPro IPR006470 Formate_DH_bsu_Proteobacteria # InterPro IPR014603 Formate_DH_Fe-S_su # InterPro IPR015246 Formate_DH_TM # InterPro IPR017896 4Fe4S_Fe-S-bd # InterPro IPR017900 4Fe4S_Fe_S_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Pathway ko00630 Glyoxylate and dicarboxylate metabolism # KEGG_Pathway ko00680 Methane metabolism # Organism FDOH_ECOLI Escherichia coli (strain K12) # PATRIC 32123293 VBIEscCol129921_4007 # PIR S40837 S40837 # PIRSF PIRSF036298 FDH_4Fe4S # PROSITE PS00198 4FE4S_FER_1 # PROSITE PS51379 4FE4S_FER_2; 4 # Pfam PF09163 Form-deh_trans # Pfam PF13247 Fer4_11 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FDOH_ECOLI Formate dehydrogenase-O iron-sulfur subunit # RefSeq NP_418329 NC_000913.3 # RefSeq WP_000331377 NZ_LN832404.1 # SIMILARITY Contains 4 4Fe-4S ferredoxin-type domains. {ECO:0000255|PROSITE-ProRule PRU00711}. # SUBCELLULAR LOCATION FDOH_ECOLI Cell membrane; Single-pass membrane protein. # SUBUNIT FDOH_ECOLI Formate dehydrogenase is a membrane-bound complex, formed by subunits alpha, beta and gamma. # TIGRFAMs TIGR01582 FDH-beta # eggNOG COG0437 LUCA # eggNOG ENOG4105QA4 Bacteria BLAST swissprot:FDOH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FDOH_ECOLI BioCyc ECOL316407:JW3864-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3864-MONOMER BioCyc EcoCyc:FDOH-MONOMER http://biocyc.org/getid?id=EcoCyc:FDOH-MONOMER BioCyc MetaCyc:FDOH-MONOMER http://biocyc.org/getid?id=MetaCyc:FDOH-MONOMER COG COG0437 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0437 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1803 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1803 EcoGene EG11857 http://www.ecogene.org/geneInfo.php?eg_id=EG11857 EnsemblBacteria AAD13455 http://www.ensemblgenomes.org/id/AAD13455 EnsemblBacteria AAD13455 http://www.ensemblgenomes.org/id/AAD13455 EnsemblBacteria BAE77416 http://www.ensemblgenomes.org/id/BAE77416 EnsemblBacteria BAE77416 http://www.ensemblgenomes.org/id/BAE77416 EnsemblBacteria BAE77416 http://www.ensemblgenomes.org/id/BAE77416 EnsemblBacteria b3893 http://www.ensemblgenomes.org/id/b3893 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0009326 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009326 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0031235 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031235 GO_function GO:0036397 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036397 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0015944 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015944 GO_process GO:0045333 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045333 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 948395 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948395 HOGENOM HOG000163382 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000163382&db=HOGENOM6 InParanoid P0AAJ5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAJ5 IntAct P0AAJ5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAJ5* InterPro IPR006470 http://www.ebi.ac.uk/interpro/entry/IPR006470 InterPro IPR014603 http://www.ebi.ac.uk/interpro/entry/IPR014603 InterPro IPR015246 http://www.ebi.ac.uk/interpro/entry/IPR015246 InterPro IPR017896 http://www.ebi.ac.uk/interpro/entry/IPR017896 InterPro IPR017900 http://www.ebi.ac.uk/interpro/entry/IPR017900 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Gene ecj:JW3864 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3864 KEGG_Gene eco:b3893 http://www.genome.jp/dbget-bin/www_bget?eco:b3893 KEGG_Orthology KO:K00124 http://www.genome.jp/dbget-bin/www_bget?KO:K00124 KEGG_Pathway ko00630 http://www.genome.jp/kegg-bin/show_pathway?ko00630 KEGG_Pathway ko00680 http://www.genome.jp/kegg-bin/show_pathway?ko00680 KEGG_Reaction rn:R00519 http://www.genome.jp/dbget-bin/www_bget?rn:R00519 OMA ISATVKF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ISATVKF PROSITE PS00198 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00198 PROSITE PS51379 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51379 PSORT swissprot:FDOH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FDOH_ECOLI PSORT-B swissprot:FDOH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FDOH_ECOLI PSORT2 swissprot:FDOH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FDOH_ECOLI Pfam PF09163 http://pfam.xfam.org/family/PF09163 Pfam PF13247 http://pfam.xfam.org/family/PF13247 Phobius swissprot:FDOH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FDOH_ECOLI PhylomeDB P0AAJ5 http://phylomedb.org/?seqid=P0AAJ5 ProteinModelPortal P0AAJ5 http://www.proteinmodelportal.org/query/uniprot/P0AAJ5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 8522521 http://www.ncbi.nlm.nih.gov/pubmed/8522521 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9852007 http://www.ncbi.nlm.nih.gov/pubmed/9852007 RefSeq NP_418329 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418329 RefSeq WP_000331377 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000331377 SMR P0AAJ5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAJ5 STRING 511145.b3893 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3893&targetmode=cogs STRING COG0437 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0437&targetmode=cogs TIGRFAMs TIGR01582 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01582 UniProtKB FDOH_ECOLI http://www.uniprot.org/uniprot/FDOH_ECOLI UniProtKB-AC P0AAJ5 http://www.uniprot.org/uniprot/P0AAJ5 charge swissprot:FDOH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FDOH_ECOLI eggNOG COG0437 http://eggnogapi.embl.de/nog_data/html/tree/COG0437 eggNOG ENOG4105QA4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105QA4 epestfind swissprot:FDOH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FDOH_ECOLI garnier swissprot:FDOH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FDOH_ECOLI helixturnhelix swissprot:FDOH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FDOH_ECOLI hmoment swissprot:FDOH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FDOH_ECOLI iep swissprot:FDOH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FDOH_ECOLI inforesidue swissprot:FDOH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FDOH_ECOLI octanol swissprot:FDOH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FDOH_ECOLI pepcoil swissprot:FDOH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FDOH_ECOLI pepdigest swissprot:FDOH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FDOH_ECOLI pepinfo swissprot:FDOH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FDOH_ECOLI pepnet swissprot:FDOH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FDOH_ECOLI pepstats swissprot:FDOH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FDOH_ECOLI pepwheel swissprot:FDOH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FDOH_ECOLI pepwindow swissprot:FDOH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FDOH_ECOLI sigcleave swissprot:FDOH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FDOH_ECOLI ## Database ID URL or Descriptions # AltName DTB synthetase 2 {ECO:0000255|HAMAP-Rule MF_00336} # AltName Dethiobiotin synthase 2 {ECO:0000255|HAMAP-Rule MF_00336} # BioGrid 4259412 13 # CATALYTIC ACTIVITY ATP + 7,8-diaminononanoate + CO(2) = ADP + phosphate + dethiobiotin. {ECO:0000255|HAMAP-Rule MF_00336}. # COFACTOR BIOD2_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_00336}; # EcoGene EG13849 ynfK # FUNCTION BIOD2_ECOLI Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring. {ECO 0000255|HAMAP-Rule MF_00336}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0004141 dethiobiotin synthase activity; IBA:GO_Central. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_process GO:0009102 biotin biosynthetic process; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.300 -; 1. # HAMAP MF_00336 BioD # IntAct P0A6E9 3 # InterPro IPR004472 DTB_synth_BioD # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00780 Biotin metabolism # Organism BIOD2_ECOLI Escherichia coli (strain K12) # PATHWAY Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. {ECO 0000255|HAMAP-Rule:MF_00336}. # PATRIC 32118488 VBIEscCol129921_1664 # PIR C64915 C64915 # PIRSF PIRSF006755 DTB_synth # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ATP-dependent dethiobiotin synthetase BioD 2 {ECO:0000255|HAMAP-Rule MF_00336} # RefSeq NP_416110 NC_000913.3 # RefSeq WP_000919231 NZ_LN832404.1 # SIMILARITY Belongs to the dethiobiotin synthetase family. {ECO:0000255|HAMAP-Rule MF_00336}. # SUBCELLULAR LOCATION BIOD2_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00336}. # SUBUNIT Homodimer. {ECO:0000255|HAMAP-Rule MF_00336}. # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR00347 bioD # UniPathway UPA00078 UER00161 # eggNOG COG0132 LUCA # eggNOG ENOG4105EWW Bacteria BLAST swissprot:BIOD2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BIOD2_ECOLI BioCyc ECOL316407:JW5264-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5264-MONOMER BioCyc EcoCyc:G6851-MONOMER http://biocyc.org/getid?id=EcoCyc:G6851-MONOMER COG COG0132 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0132 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.3.3.3 {ECO:0000255|HAMAP-Rule:MF_00336} http://www.genome.jp/dbget-bin/www_bget?EC:6.3.3.3 {ECO:0000255|HAMAP-Rule:MF_00336} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 6.3.3.3 {ECO:0000255|HAMAP-Rule:MF_00336} http://enzyme.expasy.org/EC/6.3.3.3 {ECO:0000255|HAMAP-Rule:MF_00336} EchoBASE EB3610 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3610 EcoGene EG13849 http://www.ecogene.org/geneInfo.php?eg_id=EG13849 EnsemblBacteria AAC74665 http://www.ensemblgenomes.org/id/AAC74665 EnsemblBacteria AAC74665 http://www.ensemblgenomes.org/id/AAC74665 EnsemblBacteria BAA15317 http://www.ensemblgenomes.org/id/BAA15317 EnsemblBacteria BAA15317 http://www.ensemblgenomes.org/id/BAA15317 EnsemblBacteria BAA15317 http://www.ensemblgenomes.org/id/BAA15317 EnsemblBacteria b1593 http://www.ensemblgenomes.org/id/b1593 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0004141 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004141 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0009102 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009102 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 944927 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944927 HAMAP MF_00336 http://hamap.expasy.org/unirule/MF_00336 HOGENOM HOG000275032 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275032&db=HOGENOM6 InParanoid P0A6E9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6E9 IntAct P0A6E9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6E9* IntEnz 6.3.3.3 {ECO:0000255|HAMAP-Rule:MF_00336} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.3.3 {ECO:0000255|HAMAP-Rule:MF_00336} InterPro IPR004472 http://www.ebi.ac.uk/interpro/entry/IPR004472 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5264 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5264 KEGG_Gene eco:b1593 http://www.genome.jp/dbget-bin/www_bget?eco:b1593 KEGG_Orthology KO:K01935 http://www.genome.jp/dbget-bin/www_bget?KO:K01935 KEGG_Pathway ko00780 http://www.genome.jp/kegg-bin/show_pathway?ko00780 KEGG_Reaction rn:R03182 http://www.genome.jp/dbget-bin/www_bget?rn:R03182 OMA ANRINPC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ANRINPC PSORT swissprot:BIOD2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BIOD2_ECOLI PSORT-B swissprot:BIOD2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BIOD2_ECOLI PSORT2 swissprot:BIOD2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BIOD2_ECOLI Phobius swissprot:BIOD2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BIOD2_ECOLI PhylomeDB P0A6E9 http://phylomedb.org/?seqid=P0A6E9 ProteinModelPortal P0A6E9 http://www.proteinmodelportal.org/query/uniprot/P0A6E9 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416110 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416110 RefSeq WP_000919231 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000919231 SMR P0A6E9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6E9 STRING 511145.b1593 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1593&targetmode=cogs STRING COG0132 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0132&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR00347 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00347 UniProtKB BIOD2_ECOLI http://www.uniprot.org/uniprot/BIOD2_ECOLI UniProtKB-AC P0A6E9 http://www.uniprot.org/uniprot/P0A6E9 charge swissprot:BIOD2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BIOD2_ECOLI eggNOG COG0132 http://eggnogapi.embl.de/nog_data/html/tree/COG0132 eggNOG ENOG4105EWW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EWW epestfind swissprot:BIOD2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BIOD2_ECOLI garnier swissprot:BIOD2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BIOD2_ECOLI helixturnhelix swissprot:BIOD2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BIOD2_ECOLI hmoment swissprot:BIOD2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BIOD2_ECOLI iep swissprot:BIOD2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BIOD2_ECOLI inforesidue swissprot:BIOD2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BIOD2_ECOLI octanol swissprot:BIOD2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BIOD2_ECOLI pepcoil swissprot:BIOD2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BIOD2_ECOLI pepdigest swissprot:BIOD2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BIOD2_ECOLI pepinfo swissprot:BIOD2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BIOD2_ECOLI pepnet swissprot:BIOD2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BIOD2_ECOLI pepstats swissprot:BIOD2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BIOD2_ECOLI pepwheel swissprot:BIOD2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BIOD2_ECOLI pepwindow swissprot:BIOD2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BIOD2_ECOLI sigcleave swissprot:BIOD2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BIOD2_ECOLI ## Database ID URL or Descriptions # BioGrid 4261386 6 # EcoGene EG13418 csiE # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:InterPro. # GOslim_process GO:0008150 biological_process # Gene3D 1.10.1790.10 -; 1. # InterPro IPR011608 PRD # Organism CSIE_ECOLI Escherichia coli (strain K12) # PATRIC 32120467 VBIEscCol129921_2636 # PROSITE PS51372 PRD_2; 2 # Pfam PF00874 PRD; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CSIE_ECOLI Stationary phase-inducible protein CsiE # RefSeq NP_417030 NC_000913.3 # RefSeq WP_000982994 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA98796.1; Type=Frameshift; Positions=391; Evidence={ECO 0000305}; # SIMILARITY Contains 2 PRD domains. {ECO:0000255|PROSITE- ProRule PRU00704}. # SUPFAM SSF63520 SSF63520 # eggNOG COG3711 LUCA # eggNOG ENOG4108MN2 Bacteria BLAST swissprot:CSIE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CSIE_ECOLI BioCyc ECOL316407:JW5878-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5878-MONOMER BioCyc EcoCyc:G7329-MONOMER http://biocyc.org/getid?id=EcoCyc:G7329-MONOMER DIP DIP-9332N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9332N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L77687 http://www.ebi.ac.uk/ena/data/view/L77687 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3194 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3194 EcoGene EG13418 http://www.ecogene.org/geneInfo.php?eg_id=EG13418 EnsemblBacteria AAC75588 http://www.ensemblgenomes.org/id/AAC75588 EnsemblBacteria AAC75588 http://www.ensemblgenomes.org/id/AAC75588 EnsemblBacteria BAA16429 http://www.ensemblgenomes.org/id/BAA16429 EnsemblBacteria BAA16429 http://www.ensemblgenomes.org/id/BAA16429 EnsemblBacteria BAA16429 http://www.ensemblgenomes.org/id/BAA16429 EnsemblBacteria b2535 http://www.ensemblgenomes.org/id/b2535 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.10.1790.10 http://www.cathdb.info/version/latest/superfamily/1.10.1790.10 GeneID 947009 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947009 HOGENOM HOG000123491 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000123491&db=HOGENOM6 InParanoid P54901 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P54901 InterPro IPR011608 http://www.ebi.ac.uk/interpro/entry/IPR011608 KEGG_Gene ecj:JW5878 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5878 KEGG_Gene eco:b2535 http://www.genome.jp/dbget-bin/www_bget?eco:b2535 OMA FFAIGID http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FFAIGID PROSITE PS51372 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51372 PSORT swissprot:CSIE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CSIE_ECOLI PSORT-B swissprot:CSIE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CSIE_ECOLI PSORT2 swissprot:CSIE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CSIE_ECOLI Pfam PF00874 http://pfam.xfam.org/family/PF00874 Phobius swissprot:CSIE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CSIE_ECOLI ProteinModelPortal P54901 http://www.proteinmodelportal.org/query/uniprot/P54901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417030 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417030 RefSeq WP_000982994 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000982994 SMR P54901 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P54901 STRING 511145.b2535 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2535&targetmode=cogs SUPFAM SSF63520 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63520 UniProtKB CSIE_ECOLI http://www.uniprot.org/uniprot/CSIE_ECOLI UniProtKB-AC P54901 http://www.uniprot.org/uniprot/P54901 charge swissprot:CSIE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CSIE_ECOLI eggNOG COG3711 http://eggnogapi.embl.de/nog_data/html/tree/COG3711 eggNOG ENOG4108MN2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MN2 epestfind swissprot:CSIE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CSIE_ECOLI garnier swissprot:CSIE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CSIE_ECOLI helixturnhelix swissprot:CSIE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CSIE_ECOLI hmoment swissprot:CSIE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CSIE_ECOLI iep swissprot:CSIE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CSIE_ECOLI inforesidue swissprot:CSIE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CSIE_ECOLI octanol swissprot:CSIE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CSIE_ECOLI pepcoil swissprot:CSIE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CSIE_ECOLI pepdigest swissprot:CSIE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CSIE_ECOLI pepinfo swissprot:CSIE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CSIE_ECOLI pepnet swissprot:CSIE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CSIE_ECOLI pepstats swissprot:CSIE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CSIE_ECOLI pepwheel swissprot:CSIE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CSIE_ECOLI pepwindow swissprot:CSIE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CSIE_ECOLI sigcleave swissprot:CSIE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CSIE_ECOLI ## Database ID URL or Descriptions # BioGrid 4260844 23 # EcoGene EG10919 rpsT # FUNCTION RS20_ECOLI Binds directly to 16S ribosomal RNA. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0022627 cytosolic small ribosomal subunit; IDA:EcoliWiki. # GO_function GO:0003735 structural constituent of ribosome; IEA:InterPro. # GO_function GO:0008073 ornithine decarboxylase inhibitor activity; IDA:EcoCyc. # GO_function GO:0070181 small ribosomal subunit rRNA binding; IDA:EcoCyc. # GO_process GO:0006412 translation; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_function GO:0019843 rRNA binding # GOslim_function GO:0030234 enzyme regulator activity # GOslim_process GO:0006412 translation # Gene3D 1.20.58.110 -; 1. # HAMAP MF_00500 Ribosomal_S20 # IntAct P0A7U7 57 # InterPro IPR002583 Ribosomal_S20 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=9553.6; Method=MALDI; Range=2-87; Evidence={ECO:0000269|PubMed 10094780}; # Organism RS20_ECOLI Escherichia coli (strain K12) # PATRIC 32115137 VBIEscCol129921_0020 # PDB 1M5G Model; -; T=3-87 # PDB 2YKR EM; 9.80 A; T=3-87 # PDB 3J9Y EM; 3.90 A; t=1-87 # PDB 3J9Z EM; 3.60 A; ST=2-87 # PDB 3JA1 EM; 3.60 A; ST=2-87 # PDB 3JBU EM; 3.64 A; T=1-87 # PDB 3JBV EM; 3.32 A; T=1-87 # PDB 3JCD EM; 3.70 A; t=1-87 # PDB 3JCE EM; 3.20 A; t=1-87 # PDB 3JCJ EM; 3.70 A; 3=1-87 # PDB 3JCN EM; 4.60 A; x=1-87 # PDB 4A2I EM; 16.50 A; T=3-87 # PDB 4ADV EM; 13.50 A; T=2-87 # PDB 4U1U X-ray; 2.95 A; AT/CT=3-87 # PDB 4U1V X-ray; 3.00 A; AT/CT=3-87 # PDB 4U20 X-ray; 2.90 A; AT/CT=3-87 # PDB 4U24 X-ray; 2.90 A; AT/CT=3-87 # PDB 4U25 X-ray; 2.90 A; AT/CT=3-87 # PDB 4U26 X-ray; 2.80 A; AT/CT=3-87 # PDB 4U27 X-ray; 2.80 A; AT/CT=3-87 # PDB 4V47 EM; 12.30 A; BT=2-87 # PDB 4V48 EM; 11.50 A; BT=2-87 # PDB 4V4H X-ray; 3.46 A; AT/CT=1-87 # PDB 4V4Q X-ray; 3.46 A; AT/CT=2-87 # PDB 4V4V EM; 15.00 A; AT=5-87 # PDB 4V4W EM; 15.00 A; AT=5-87 # PDB 4V50 X-ray; 3.22 A; AT/CT=2-87 # PDB 4V52 X-ray; 3.21 A; AT/CT=2-87 # PDB 4V53 X-ray; 3.54 A; AT/CT=2-87 # PDB 4V54 X-ray; 3.30 A; AT/CT=2-87 # PDB 4V55 X-ray; 4.00 A; AT/CT=2-87 # PDB 4V56 X-ray; 3.93 A; AT/CT=2-87 # PDB 4V57 X-ray; 3.50 A; AT/CT=2-87 # PDB 4V5B X-ray; 3.74 A; BT/DT=2-87 # PDB 4V5H EM; 5.80 A; AT=3-87 # PDB 4V5Y X-ray; 4.45 A; AT/CT=2-87 # PDB 4V64 X-ray; 3.50 A; AT/CT=2-87 # PDB 4V65 EM; 9.00 A; AN=1-87 # PDB 4V66 EM; 9.00 A; AN=1-87 # PDB 4V69 EM; 6.70 A; AT=3-87 # PDB 4V6C X-ray; 3.19 A; AT/CT=1-87 # PDB 4V6D X-ray; 3.81 A; AT/CT=1-87 # PDB 4V6E X-ray; 3.71 A; AT/CT=1-87 # PDB 4V6K EM; 8.25 A; BX=1-87 # PDB 4V6L EM; 13.20 A; AX=1-87 # PDB 4V6M EM; 7.10 A; AT=2-87 # PDB 4V6N EM; 12.10 A; BW=2-87 # PDB 4V6O EM; 14.70 A; AW=2-87 # PDB 4V6P EM; 13.50 A; AW=2-87 # PDB 4V6Q EM; 11.50 A; AW=2-87 # PDB 4V6R EM; 11.50 A; AW=2-87 # PDB 4V6S EM; 13.10 A; BV=2-87 # PDB 4V6T EM; 8.30 A; AT=3-87 # PDB 4V6V EM; 9.80 A; AT=2-87 # PDB 4V6Y EM; 12.00 A; AT=3-87 # PDB 4V6Z EM; 12.00 A; AT=3-87 # PDB 4V70 EM; 17.00 A; AT=3-87 # PDB 4V71 EM; 20.00 A; AT=3-87 # PDB 4V72 EM; 13.00 A; AT=3-87 # PDB 4V73 EM; 15.00 A; AT=3-87 # PDB 4V74 EM; 17.00 A; AT=3-87 # PDB 4V75 EM; 12.00 A; AT=3-87 # PDB 4V76 EM; 17.00 A; AT=3-87 # PDB 4V77 EM; 17.00 A; AT=3-87 # PDB 4V78 EM; 20.00 A; AT=3-87 # PDB 4V79 EM; 15.00 A; AT=3-87 # PDB 4V7A EM; 9.00 A; AT=3-87 # PDB 4V7B EM; 6.80 A; AT=1-87 # PDB 4V7C EM; 7.60 A; AT=2-87 # PDB 4V7D EM; 7.60 A; BT=2-87 # PDB 4V7I EM; 9.60 A; BT=1-87 # PDB 4V7S X-ray; 3.25 A; AT/CT=3-87 # PDB 4V7T X-ray; 3.19 A; AT/CT=3-87 # PDB 4V7U X-ray; 3.10 A; AT/CT=3-87 # PDB 4V7V X-ray; 3.29 A; AT/CT=3-87 # PDB 4V85 X-ray; 3.20 A; AT=1-87 # PDB 4V89 X-ray; 3.70 A; AT=1-87 # PDB 4V9C X-ray; 3.30 A; AT/CT=1-87 # PDB 4V9D X-ray; 3.00 A; AT/BT=3-87 # PDB 4V9O X-ray; 2.90 A; BT/DT/FT/HT=1-87 # PDB 4V9P X-ray; 2.90 A; BT/DT/FT/HT=1-87 # PDB 4WF1 X-ray; 3.09 A; AT/CT=3-87 # PDB 4WOI X-ray; 3.00 A; AT/DT=1-87 # PDB 4WWW X-ray; 3.10 A; QT/XT=3-87 # PDB 4YBB X-ray; 2.10 A; AT/BT=2-87 # PDB 5AFI EM; 2.90 A; t=1-87 # PDB 5IQR EM; 3.00 A; y=1-87 # PDB 5IT8 X-ray; 3.12 A; AT/BT=2-87 # PDB 5J5B X-ray; 2.80 A; AT/BT=2-87 # PDB 5J7L X-ray; 3.00 A; AT/BT=2-87 # PDB 5J88 X-ray; 3.32 A; AT/BT=2-87 # PDB 5J8A X-ray; 3.10 A; AT/BT=2-87 # PDB 5J91 X-ray; 2.96 A; AT/BT=2-87 # PDB 5JC9 X-ray; 3.03 A; AT/BT=2-87 # PDB 5JTE EM; 3.60 A; AT=1-87 # PDB 5JU8 EM; 3.60 A; AT=1-87 # PDB 5KCR EM; 3.60 A; 1t=1-87 # PDB 5KCS EM; 3.90 A; 1t=1-87 # PDB 5KPS EM; 3.90 A; 25=1-87 # PDB 5KPV EM; 4.10 A; 24=1-87 # PDB 5KPW EM; 3.90 A; 24=1-87 # PDB 5KPX EM; 3.90 A; 24=1-87 # PDB 5L3P EM; 3.70 A; t=1-87 # PIR A30425 R3EC20 # Pfam PF01649 Ribosomal_S20p # ProDom PD004231 Ribosomal_S20 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RS20_ECOLI 30S ribosomal protein S20 # RefSeq NP_414564 NC_000913.3 # RefSeq WP_001274021 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein S20P family. {ECO 0000305}. # SUPFAM SSF46992 SSF46992 # TIGRFAMs TIGR00029 S20 # eggNOG COG0268 LUCA # eggNOG ENOG4105KQV Bacteria BLAST swissprot:RS20_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RS20_ECOLI BioCyc ECOL316407:JW0022-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0022-MONOMER BioCyc EcoCyc:EG10919-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10919-MONOMER BioCyc MetaCyc:EG10919-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10919-MONOMER COG COG0268 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0268 DIP DIP-35857N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35857N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1016/0014-5793(76)80416-4 http://dx.doi.org/10.1016/0014-5793(76)80416-4 DOI 10.1016/S0092-8674(03)00427-6 http://dx.doi.org/10.1016/S0092-8674(03)00427-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb841 http://dx.doi.org/10.1038/nsb841 DOI 10.1093/nar/14.17.6965 http://dx.doi.org/10.1093/nar/14.17.6965 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M10428 http://www.ebi.ac.uk/ena/data/view/M10428 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X04382 http://www.ebi.ac.uk/ena/data/view/X04382 EchoBASE EB0912 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0912 EcoGene EG10919 http://www.ecogene.org/geneInfo.php?eg_id=EG10919 EnsemblBacteria AAC73134 http://www.ensemblgenomes.org/id/AAC73134 EnsemblBacteria AAC73134 http://www.ensemblgenomes.org/id/AAC73134 EnsemblBacteria BAB96593 http://www.ensemblgenomes.org/id/BAB96593 EnsemblBacteria BAB96593 http://www.ensemblgenomes.org/id/BAB96593 EnsemblBacteria BAB96593 http://www.ensemblgenomes.org/id/BAB96593 EnsemblBacteria b0023 http://www.ensemblgenomes.org/id/b0023 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0022627 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022627 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_function GO:0008073 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008073 GO_function GO:0070181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070181 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 Gene3D 1.20.58.110 http://www.cathdb.info/version/latest/superfamily/1.20.58.110 GeneID 944759 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944759 HAMAP MF_00500 http://hamap.expasy.org/unirule/MF_00500 HOGENOM HOG000097048 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000097048&db=HOGENOM6 InParanoid P0A7U7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7U7 IntAct P0A7U7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7U7* InterPro IPR002583 http://www.ebi.ac.uk/interpro/entry/IPR002583 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW0022 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0022 KEGG_Gene eco:b0023 http://www.genome.jp/dbget-bin/www_bget?eco:b0023 KEGG_Orthology KO:K02968 http://www.genome.jp/dbget-bin/www_bget?KO:K02968 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 OMA HACKGLI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HACKGLI PDB 1M5G http://www.ebi.ac.uk/pdbe-srv/view/entry/1M5G PDB 2YKR http://www.ebi.ac.uk/pdbe-srv/view/entry/2YKR PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 4A2I http://www.ebi.ac.uk/pdbe-srv/view/entry/4A2I PDB 4ADV http://www.ebi.ac.uk/pdbe-srv/view/entry/4ADV PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4V47 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V47 PDB 4V48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V48 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 1M5G http://www.ebi.ac.uk/pdbsum/1M5G PDBsum 2YKR http://www.ebi.ac.uk/pdbsum/2YKR PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 4A2I http://www.ebi.ac.uk/pdbsum/4A2I PDBsum 4ADV http://www.ebi.ac.uk/pdbsum/4ADV PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4V47 http://www.ebi.ac.uk/pdbsum/4V47 PDBsum 4V48 http://www.ebi.ac.uk/pdbsum/4V48 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PSORT swissprot:RS20_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RS20_ECOLI PSORT-B swissprot:RS20_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RS20_ECOLI PSORT2 swissprot:RS20_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RS20_ECOLI Pfam PF01649 http://pfam.xfam.org/family/PF01649 Phobius swissprot:RS20_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RS20_ECOLI PhylomeDB P0A7U7 http://phylomedb.org/?seqid=P0A7U7 ProteinModelPortal P0A7U7 http://www.proteinmodelportal.org/query/uniprot/P0A7U7 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 12244297 http://www.ncbi.nlm.nih.gov/pubmed/12244297 PubMed 12809609 http://www.ncbi.nlm.nih.gov/pubmed/12809609 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2429258 http://www.ncbi.nlm.nih.gov/pubmed/2429258 PubMed 2985604 http://www.ncbi.nlm.nih.gov/pubmed/2985604 PubMed 6267039 http://www.ncbi.nlm.nih.gov/pubmed/6267039 PubMed 786731 http://www.ncbi.nlm.nih.gov/pubmed/786731 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_414564 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414564 RefSeq WP_001274021 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001274021 SMR P0A7U7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7U7 STRING 511145.b0023 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0023&targetmode=cogs STRING COG0268 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0268&targetmode=cogs SUPFAM SSF46992 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46992 TIGRFAMs TIGR00029 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00029 UniProtKB RS20_ECOLI http://www.uniprot.org/uniprot/RS20_ECOLI UniProtKB-AC P0A7U7 http://www.uniprot.org/uniprot/P0A7U7 charge swissprot:RS20_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RS20_ECOLI eggNOG COG0268 http://eggnogapi.embl.de/nog_data/html/tree/COG0268 eggNOG ENOG4105KQV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KQV epestfind swissprot:RS20_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RS20_ECOLI garnier swissprot:RS20_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RS20_ECOLI helixturnhelix swissprot:RS20_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RS20_ECOLI hmoment swissprot:RS20_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RS20_ECOLI iep swissprot:RS20_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RS20_ECOLI inforesidue swissprot:RS20_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RS20_ECOLI octanol swissprot:RS20_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RS20_ECOLI pepcoil swissprot:RS20_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RS20_ECOLI pepdigest swissprot:RS20_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RS20_ECOLI pepinfo swissprot:RS20_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RS20_ECOLI pepnet swissprot:RS20_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RS20_ECOLI pepstats swissprot:RS20_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RS20_ECOLI pepwheel swissprot:RS20_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RS20_ECOLI pepwindow swissprot:RS20_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RS20_ECOLI sigcleave swissprot:RS20_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RS20_ECOLI ## Database ID URL or Descriptions # BioGrid 4261431 6 # EcoGene EG14219 hyfR # FUNCTION HYFR_ECOLI Required for induction of expression of the hydrogenase- 4 structural genes. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_function GO:0003677 DNA binding; IDA:EcoliWiki. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0043565 sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0000160 phosphorelay signal transduction system; IEA:UniProtKB-KW. # GO_process GO:0006352 DNA-templated transcription, initiation; IMP:EcoliWiki. # GO_process GO:2000142 regulation of DNA-templated transcription, initiation; IMP:EcoCyc. # GOslim_component GO:0005622 intracellular # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.60 -; 1. # Gene3D 3.30.450.40 -; 1. # Gene3D 3.40.50.300 -; 1. # IntAct P71229 13 # InterPro IPR002078 Sigma_54_int # InterPro IPR002197 HTH_Fis # InterPro IPR003018 GAF # InterPro IPR003593 AAA+_ATPase # InterPro IPR009057 Homeodomain-like # InterPro IPR025662 Sigma_54_int_dom_ATP-bd_1 # InterPro IPR025943 Sigma_54_int_dom_ATP-bd_2 # InterPro IPR025944 Sigma_54_int_dom_CS # InterPro IPR027417 P-loop_NTPase # InterPro IPR029016 GAF_dom-like # KEGG_Brite ko03000 Transcription factors # Organism HYFR_ECOLI Escherichia coli (strain K12) # PATRIC 32120369 VBIEscCol129921_2587 # PIR B65025 B65025 # PROSITE PS00675 SIGMA54_INTERACT_1 # PROSITE PS00676 SIGMA54_INTERACT_2 # PROSITE PS00688 SIGMA54_INTERACT_3 # PROSITE PS50045 SIGMA54_INTERACT_4 # Pfam PF00158 Sigma54_activat # Pfam PF01590 GAF # Pfam PF02954 HTH_8 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HYFR_ECOLI Hydrogenase-4 transcriptional activator # RefSeq NP_416986 NC_000913.3 # RefSeq WP_001251544 NZ_LN832404.1 # SIMILARITY Contains 1 GAF domain. {ECO 0000305}. # SIMILARITY Contains 1 sigma-54 factor interaction domain. {ECO:0000255|PROSITE-ProRule PRU00193}. # SMART SM00065 GAF # SMART SM00382 AAA # SUPFAM SSF46689 SSF46689 # SUPFAM SSF52540 SSF52540 # SUPFAM SSF55781 SSF55781 # eggNOG COG3604 LUCA # eggNOG ENOG4108JUA Bacteria BLAST swissprot:HYFR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HYFR_ECOLI BioCyc ECOL316407:JW2476-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2476-MONOMER BioCyc EcoCyc:G7308-MONOMER http://biocyc.org/getid?id=EcoCyc:G7308-MONOMER COG COG3604 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3604 DIP DIP-9993N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9993N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M63654 http://www.ebi.ac.uk/ena/data/view/M63654 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3971 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3971 EcoGene EG14219 http://www.ecogene.org/geneInfo.php?eg_id=EG14219 EnsemblBacteria AAC75544 http://www.ensemblgenomes.org/id/AAC75544 EnsemblBacteria AAC75544 http://www.ensemblgenomes.org/id/AAC75544 EnsemblBacteria BAA16380 http://www.ensemblgenomes.org/id/BAA16380 EnsemblBacteria BAA16380 http://www.ensemblgenomes.org/id/BAA16380 EnsemblBacteria BAA16380 http://www.ensemblgenomes.org/id/BAA16380 EnsemblBacteria b2491 http://www.ensemblgenomes.org/id/b2491 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006352 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006352 GO_process GO:2000142 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000142 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 Gene3D 3.30.450.40 http://www.cathdb.info/version/latest/superfamily/3.30.450.40 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948886 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948886 HOGENOM HOG000058488 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000058488&db=HOGENOM6 InParanoid P71229 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P71229 IntAct P71229 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P71229* InterPro IPR002078 http://www.ebi.ac.uk/interpro/entry/IPR002078 InterPro IPR002197 http://www.ebi.ac.uk/interpro/entry/IPR002197 InterPro IPR003018 http://www.ebi.ac.uk/interpro/entry/IPR003018 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR025662 http://www.ebi.ac.uk/interpro/entry/IPR025662 InterPro IPR025943 http://www.ebi.ac.uk/interpro/entry/IPR025943 InterPro IPR025944 http://www.ebi.ac.uk/interpro/entry/IPR025944 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR029016 http://www.ebi.ac.uk/interpro/entry/IPR029016 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW2476 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2476 KEGG_Gene eco:b2491 http://www.genome.jp/dbget-bin/www_bget?eco:b2491 KEGG_Orthology KO:K12146 http://www.genome.jp/dbget-bin/www_bget?KO:K12146 MINT MINT-1219276 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1219276 OMA SWLNDEA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SWLNDEA PROSITE PS00675 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00675 PROSITE PS00676 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00676 PROSITE PS00688 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00688 PROSITE PS50045 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50045 PSORT swissprot:HYFR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HYFR_ECOLI PSORT-B swissprot:HYFR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HYFR_ECOLI PSORT2 swissprot:HYFR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HYFR_ECOLI Pfam PF00158 http://pfam.xfam.org/family/PF00158 Pfam PF01590 http://pfam.xfam.org/family/PF01590 Pfam PF02954 http://pfam.xfam.org/family/PF02954 Phobius swissprot:HYFR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HYFR_ECOLI PhylomeDB P71229 http://phylomedb.org/?seqid=P71229 ProteinModelPortal P71229 http://www.proteinmodelportal.org/query/uniprot/P71229 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416986 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416986 RefSeq WP_001251544 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001251544 SMART SM00065 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00065 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P71229 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P71229 STRING 511145.b2491 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2491&targetmode=cogs STRING COG3604 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3604&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SUPFAM SSF55781 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55781 UniProtKB HYFR_ECOLI http://www.uniprot.org/uniprot/HYFR_ECOLI UniProtKB-AC P71229 http://www.uniprot.org/uniprot/P71229 charge swissprot:HYFR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HYFR_ECOLI eggNOG COG3604 http://eggnogapi.embl.de/nog_data/html/tree/COG3604 eggNOG ENOG4108JUA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108JUA epestfind swissprot:HYFR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HYFR_ECOLI garnier swissprot:HYFR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HYFR_ECOLI helixturnhelix swissprot:HYFR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HYFR_ECOLI hmoment swissprot:HYFR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HYFR_ECOLI iep swissprot:HYFR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HYFR_ECOLI inforesidue swissprot:HYFR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HYFR_ECOLI octanol swissprot:HYFR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HYFR_ECOLI pepcoil swissprot:HYFR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HYFR_ECOLI pepdigest swissprot:HYFR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HYFR_ECOLI pepinfo swissprot:HYFR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HYFR_ECOLI pepnet swissprot:HYFR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HYFR_ECOLI pepstats swissprot:HYFR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HYFR_ECOLI pepwheel swissprot:HYFR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HYFR_ECOLI pepwindow swissprot:HYFR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HYFR_ECOLI sigcleave swissprot:HYFR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HYFR_ECOLI ## Database ID URL or Descriptions # BioGrid 4260495 6 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG12881 yfaH # InterPro IPR020093 Uncharacterised_YfaH_C # Organism YFAH_ECOLI Escherichia coli (strain K12) # PATRIC 48663860 VBIEscCol107702_2272 # PIR D64994 D64994 # ProDom PD055259 Uncharacterised_YfaH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFAH_ECOLI Putative uncharacterized protein YfaH # RefSeq WP_001009397 NZ_LN832404.1 # eggNOG ENOG4107R11 Bacteria # eggNOG ENOG410XP61 LUCA BLAST swissprot:YFAH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFAH_ECOLI BioCyc ECOL316407:JW2232-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2232-MONOMER BioCyc EcoCyc:EG12881-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12881-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.81.14.4294 http://dx.doi.org/10.1073/pnas.81.14.4294 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K02672 http://www.ebi.ac.uk/ena/data/view/K02672 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2719 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2719 EcoGene EG12881 http://www.ecogene.org/geneInfo.php?eg_id=EG12881 EnsemblBacteria BAA16057 http://www.ensemblgenomes.org/id/BAA16057 EnsemblBacteria BAA16057 http://www.ensemblgenomes.org/id/BAA16057 EnsemblBacteria BAA16057 http://www.ensemblgenomes.org/id/BAA16057 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv InterPro IPR020093 http://www.ebi.ac.uk/interpro/entry/IPR020093 KEGG_Gene ecj:JW2232 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2232 PSORT swissprot:YFAH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFAH_ECOLI PSORT-B swissprot:YFAH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFAH_ECOLI PSORT2 swissprot:YFAH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFAH_ECOLI Phobius swissprot:YFAH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFAH_ECOLI ProteinModelPortal P45505 http://www.proteinmodelportal.org/query/uniprot/P45505 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6087316 http://www.ncbi.nlm.nih.gov/pubmed/6087316 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001009397 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001009397 STRING 316407.1799585 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.1799585&targetmode=cogs UniProtKB YFAH_ECOLI http://www.uniprot.org/uniprot/YFAH_ECOLI UniProtKB-AC P45505 http://www.uniprot.org/uniprot/P45505 charge swissprot:YFAH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFAH_ECOLI eggNOG ENOG4107R11 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107R11 eggNOG ENOG410XP61 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XP61 epestfind swissprot:YFAH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFAH_ECOLI garnier swissprot:YFAH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFAH_ECOLI helixturnhelix swissprot:YFAH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFAH_ECOLI hmoment swissprot:YFAH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFAH_ECOLI iep swissprot:YFAH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFAH_ECOLI inforesidue swissprot:YFAH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFAH_ECOLI octanol swissprot:YFAH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFAH_ECOLI pepcoil swissprot:YFAH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFAH_ECOLI pepdigest swissprot:YFAH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFAH_ECOLI pepinfo swissprot:YFAH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFAH_ECOLI pepnet swissprot:YFAH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFAH_ECOLI pepstats swissprot:YFAH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFAH_ECOLI pepwheel swissprot:YFAH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFAH_ECOLI pepwindow swissprot:YFAH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFAH_ECOLI sigcleave swissprot:YFAH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFAH_ECOLI ## Database ID URL or Descriptions # DOMAIN RHSB_ECOLI Each rhs appears to consist of a highly conserved 141 kDa amino fragment followed by a highly divergent C-terminus. # EcoGene EG10847 rhsB # FUNCTION RHSB_ECOLI Rhs elements have a nonessential function. They may play an important role in the natural ecology of the cell. # GO_process GO:0097264 self proteolysis; IEA:InterPro. # GOslim_process GO:0008150 biological_process # InterPro IPR001826 RHS # InterPro IPR006530 YD # InterPro IPR022385 Rhs_assc_core # InterPro IPR025479 DUF4329 # InterPro IPR031325 RHS_repeat # Organism RHSB_ECOLI Escherichia coli (strain K12) # PATRIC 32122408 VBIEscCol129921_3581 # PIR E65145 E65145 # PRINTS PR00394 RHSPROTEIN # Pfam PF03527 RHS # Pfam PF05593 RHS_repeat; 7 # Pfam PF14220 DUF4329 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RHSB_ECOLI Protein RhsB # RefSeq WP_000015298 NZ_LN832404.1 # RefSeq YP_026224 NC_000913.3 # SIMILARITY Belongs to the RHS family. {ECO 0000305}. # TIGRFAMs TIGR01643 YD_repeat_2x; 5 # TIGRFAMs TIGR03696 Rhs_assc_core # eggNOG COG3209 LUCA # eggNOG ENOG4105CNA Bacteria BLAST swissprot:RHSB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RHSB_ECOLI BioCyc ECOL316407:JW5679-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5679-MONOMER BioCyc EcoCyc:EG10847-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10847-MONOMER DIP DIP-10700N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10700N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1111/j.1365-2958.1994.tb01074.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb01074.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L02370 http://www.ebi.ac.uk/ena/data/view/L02370 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0840 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0840 EcoGene EG10847 http://www.ecogene.org/geneInfo.php?eg_id=EG10847 EnsemblBacteria AAT48186 http://www.ensemblgenomes.org/id/AAT48186 EnsemblBacteria AAT48186 http://www.ensemblgenomes.org/id/AAT48186 EnsemblBacteria BAE77811 http://www.ensemblgenomes.org/id/BAE77811 EnsemblBacteria BAE77811 http://www.ensemblgenomes.org/id/BAE77811 EnsemblBacteria BAE77811 http://www.ensemblgenomes.org/id/BAE77811 EnsemblBacteria b3482 http://www.ensemblgenomes.org/id/b3482 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0097264 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097264 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 947994 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947994 HOGENOM HOG000225201 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000225201&db=HOGENOM6 InParanoid P16917 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P16917 IntAct P16917 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P16917* InterPro IPR001826 http://www.ebi.ac.uk/interpro/entry/IPR001826 InterPro IPR006530 http://www.ebi.ac.uk/interpro/entry/IPR006530 InterPro IPR022385 http://www.ebi.ac.uk/interpro/entry/IPR022385 InterPro IPR025479 http://www.ebi.ac.uk/interpro/entry/IPR025479 InterPro IPR031325 http://www.ebi.ac.uk/interpro/entry/IPR031325 KEGG_Gene ecj:JW5679 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5679 KEGG_Gene eco:b3482 http://www.genome.jp/dbget-bin/www_bget?eco:b3482 MINT MINT-1269547 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1269547 OMA AMTGPDK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AMTGPDK PRINTS PR00394 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00394 PSORT swissprot:RHSB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RHSB_ECOLI PSORT-B swissprot:RHSB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RHSB_ECOLI PSORT2 swissprot:RHSB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RHSB_ECOLI Pfam PF03527 http://pfam.xfam.org/family/PF03527 Pfam PF05593 http://pfam.xfam.org/family/PF05593 Pfam PF14220 http://pfam.xfam.org/family/PF14220 Phobius swissprot:RHSB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RHSB_ECOLI PhylomeDB P16917 http://phylomedb.org/?seqid=P16917 ProteinModelPortal P16917 http://www.proteinmodelportal.org/query/uniprot/P16917 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2403547 http://www.ncbi.nlm.nih.gov/pubmed/2403547 PubMed 2644231 http://www.ncbi.nlm.nih.gov/pubmed/2644231 PubMed 7934896 http://www.ncbi.nlm.nih.gov/pubmed/7934896 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 8387990 http://www.ncbi.nlm.nih.gov/pubmed/8387990 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000015298 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000015298 RefSeq YP_026224 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026224 SMR P16917 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P16917 STRING 511145.b3482 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3482&targetmode=cogs TIGRFAMs TIGR01643 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01643 TIGRFAMs TIGR03696 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03696 UniProtKB RHSB_ECOLI http://www.uniprot.org/uniprot/RHSB_ECOLI UniProtKB-AC P16917 http://www.uniprot.org/uniprot/P16917 charge swissprot:RHSB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RHSB_ECOLI eggNOG COG3209 http://eggnogapi.embl.de/nog_data/html/tree/COG3209 eggNOG ENOG4105CNA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CNA epestfind swissprot:RHSB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RHSB_ECOLI garnier swissprot:RHSB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RHSB_ECOLI helixturnhelix swissprot:RHSB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RHSB_ECOLI hmoment swissprot:RHSB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RHSB_ECOLI iep swissprot:RHSB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RHSB_ECOLI inforesidue swissprot:RHSB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RHSB_ECOLI octanol swissprot:RHSB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RHSB_ECOLI pepcoil swissprot:RHSB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RHSB_ECOLI pepdigest swissprot:RHSB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RHSB_ECOLI pepinfo swissprot:RHSB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RHSB_ECOLI pepnet swissprot:RHSB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RHSB_ECOLI pepstats swissprot:RHSB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RHSB_ECOLI pepwheel swissprot:RHSB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RHSB_ECOLI pepwindow swissprot:RHSB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RHSB_ECOLI sigcleave swissprot:RHSB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RHSB_ECOLI ## Database ID URL or Descriptions # AltName Arylamine N-acetyltransferase {ECO 0000305} # AltName Arylhydroxamate N,O-acetyltransferase {ECO 0000305} # BIOPHYSICOCHEMICAL PROPERTIES NHOA_ECOLI Kinetic parameters KM=0.55 mM for aniline {ECO 0000269|PubMed 10806332}; KM=0.41 mM for o-anisidine {ECO 0000269|PubMed 10806332}; KM=0.83 mM for p-anisidine {ECO 0000269|PubMed 10806332}; KM=0.48 mM for o-aminobenzoic acid {ECO 0000269|PubMed 10806332}; KM=0.36 mM for p-aminobenzoic acid {ECO 0000269|PubMed 10806332}; KM=1.94 mM for o-aminophenol {ECO 0000269|PubMed 10806332}; KM=1.71 mM for m-aminophenol {ECO 0000269|PubMed 10806332}; KM=0.54 mM for p-aminophenol {ECO 0000269|PubMed 10806332}; KM=0.63 mM for p-aminotoluene {ECO 0000269|PubMed 10806332}; KM=0.89 mM for p-phenetidine {ECO 0000269|PubMed 10806332}; KM=0.59 mM for isoniazid {ECO 0000269|PubMed 10806332}; Vmax=0.09 umol/min/mg enzyme with aniline as substrate {ECO 0000269|PubMed 10806332}; Vmax=0.10 umol/min/mg enzyme with o-anisidine as substrate {ECO 0000269|PubMed 10806332}; Vmax=0.47 umol/min/mg enzyme with p-anisidine as substrate {ECO 0000269|PubMed 10806332}; Vmax=0.30 umol/min/mg enzyme with o-aminobenzoic acid as substrate {ECO 0000269|PubMed 10806332}; Vmax=0.06 umol/min/mg enzyme with p-aminobenzoic acid as substrate {ECO 0000269|PubMed 10806332}; Vmax=0.67 umol/min/mg enzyme with o-aminophenol as substrate {ECO 0000269|PubMed 10806332}; Vmax=0.28 umol/min/mg enzyme with m-aminophenol as substrate {ECO 0000269|PubMed 10806332}; Vmax=0.33 umol/min/mg enzyme with p-aminophenol as substrate {ECO 0000269|PubMed 10806332}; Vmax=0.25 umol/min/mg enzyme with p-aminotoluene as substrate {ECO 0000269|PubMed 10806332}; Vmax=0.50 umol/min/mg enzyme with p-phenetidine as substrate {ECO 0000269|PubMed 10806332}; Vmax=0.17 umol/min/mg enzyme with isoniazid as substrate {ECO 0000269|PubMed 10806332}; pH dependence Optimum pH is 7.4. {ECO 0000269|PubMed 10806332}; Temperature dependence Optimum temperature is 37 degrees Celsius. {ECO 0000269|PubMed 10806332}; # BioGrid 4262892 20 # CATALYTIC ACTIVITY Acetyl-CoA + an N-hydroxyarylamine = CoA + an N-acetoxyarylamine. {ECO:0000250|UniProtKB Q00267}. # DISRUPTION PHENOTYPE Deletion mutants show marked resistance to nitro compound mutagenicity. {ECO:0000269|PubMed 12222687}. # ENZYME REGULATION Inhibited by salicylic acid, acetylsalicylic acid, 2,6-dichrolo-4-nitrophenol, N-ethylmaleimide and iodoacetamide. {ECO:0000269|PubMed 10806332}. # EcoGene EG13780 nhoA # FUNCTION NHOA_ECOLI Catalyzes the acetyl-CoA-dependent N-acetylation of aromatic amines, and, probably, the O-acetylation of N- hydroxyarylamines. In vitro, catalyzes the N-acetylation of various arylamines such as aminobenzoic acid, aminophenol, aminotoluene, phenetidine, anisidine, aniline, isoniazid and 2- amino-fluorene. N-hydroxyarylamine O-acetyltransferase activity has not been assayed directly, however, NhoA activity is required for the mutagenicity of nitroaromatic compounds, suggesting that it also has O-acetyltransferase activity. {ECO 0000269|PubMed 10806332, ECO 0000305|PubMed 12222687, ECO 0000305|PubMed 23452042}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0004060 arylamine N-acetyltransferase activity; IDA:EcoCyc. # GO_function GO:0046990 N-hydroxyarylamine O-acetyltransferase activity; IMP:EcoCyc. # GO_process GO:0008152 metabolic process; IEA:InterPro. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0008150 biological_process # IntAct P77567 7 # InterPro IPR001447 Arylamine_N-AcTrfase # KEGG_Brite ko01000 Enzymes # Organism NHOA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11786 PTHR11786 # PATRIC 32118218 VBIEscCol129921_1529 # PIR B64899 B64899 # PRINTS PR01543 ANATRNSFRASE # PTM NHOA_ECOLI Acetylated on Lys-214 and Lys-281. Deacetylated by CobB. {ECO 0000269|PubMed 23452042}. # Pfam PF00797 Acetyltransf_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName N-hydroxyarylamine O-acetyltransferase {ECO:0000303|PubMed 10806332} # RefSeq NP_415980 NC_000913.3 # RefSeq WP_000187925 NZ_LN832404.1 # SIMILARITY Belongs to the arylamine N-acetyltransferase family. {ECO 0000305}. # SUBCELLULAR LOCATION NHOA_ECOLI Cytoplasm {ECO 0000250|UniProtKB Q00267}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 10806332}. # eggNOG COG2162 LUCA # eggNOG ENOG4108MUX Bacteria BLAST swissprot:NHOA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NHOA_ECOLI BioCyc ECOL316407:JW1458-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1458-MONOMER BioCyc EcoCyc:G6770-MONOMER http://biocyc.org/getid?id=EcoCyc:G6770-MONOMER BioCyc MetaCyc:G6770-MONOMER http://biocyc.org/getid?id=MetaCyc:G6770-MONOMER COG COG2162 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2162 DOI 10.1016/S0304-4165(00)00038-6 http://dx.doi.org/10.1016/S0304-4165(00)00038-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1111/febs.12216 http://dx.doi.org/10.1111/febs.12216 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1515/BC.2002.104 http://dx.doi.org/10.1515/BC.2002.104 EC_number EC:2.3.1.118 {ECO:0000250|UniProtKB:Q00267} http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.118 {ECO:0000250|UniProtKB:Q00267} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.3.1.118 {ECO:0000250|UniProtKB:Q00267} http://enzyme.expasy.org/EC/2.3.1.118 {ECO:0000250|UniProtKB:Q00267} EchoBASE EB3542 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3542 EcoGene EG13780 http://www.ecogene.org/geneInfo.php?eg_id=EG13780 EnsemblBacteria AAC74545 http://www.ensemblgenomes.org/id/AAC74545 EnsemblBacteria AAC74545 http://www.ensemblgenomes.org/id/AAC74545 EnsemblBacteria BAA15100 http://www.ensemblgenomes.org/id/BAA15100 EnsemblBacteria BAA15100 http://www.ensemblgenomes.org/id/BAA15100 EnsemblBacteria BAA15100 http://www.ensemblgenomes.org/id/BAA15100 EnsemblBacteria b1463 http://www.ensemblgenomes.org/id/b1463 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004060 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004060 GO_function GO:0046990 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046990 GO_process GO:0008152 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008152 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 947251 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947251 HOGENOM HOG000205436 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000205436&db=HOGENOM6 InParanoid P77567 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77567 IntAct P77567 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77567* IntEnz 2.3.1.118 {ECO:0000250|UniProtKB:Q00267} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.118 {ECO:0000250|UniProtKB:Q00267} InterPro IPR001447 http://www.ebi.ac.uk/interpro/entry/IPR001447 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1458 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1458 KEGG_Gene eco:b1463 http://www.genome.jp/dbget-bin/www_bget?eco:b1463 KEGG_Orthology KO:K00675 http://www.genome.jp/dbget-bin/www_bget?KO:K00675 OMA HAGLYES http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HAGLYES PANTHER PTHR11786 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11786 PRINTS PR01543 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01543 PSORT swissprot:NHOA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NHOA_ECOLI PSORT-B swissprot:NHOA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NHOA_ECOLI PSORT2 swissprot:NHOA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NHOA_ECOLI Pfam PF00797 http://pfam.xfam.org/family/PF00797 Phobius swissprot:NHOA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NHOA_ECOLI PhylomeDB P77567 http://phylomedb.org/?seqid=P77567 ProteinModelPortal P77567 http://www.proteinmodelportal.org/query/uniprot/P77567 PubMed 10806332 http://www.ncbi.nlm.nih.gov/pubmed/10806332 PubMed 12222687 http://www.ncbi.nlm.nih.gov/pubmed/12222687 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 23452042 http://www.ncbi.nlm.nih.gov/pubmed/23452042 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415980 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415980 RefSeq WP_000187925 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000187925 SMR P77567 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77567 STRING 511145.b1463 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1463&targetmode=cogs STRING COG2162 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2162&targetmode=cogs UniProtKB NHOA_ECOLI http://www.uniprot.org/uniprot/NHOA_ECOLI UniProtKB-AC P77567 http://www.uniprot.org/uniprot/P77567 charge swissprot:NHOA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NHOA_ECOLI eggNOG COG2162 http://eggnogapi.embl.de/nog_data/html/tree/COG2162 eggNOG ENOG4108MUX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MUX epestfind swissprot:NHOA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NHOA_ECOLI garnier swissprot:NHOA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NHOA_ECOLI helixturnhelix swissprot:NHOA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NHOA_ECOLI hmoment swissprot:NHOA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NHOA_ECOLI iep swissprot:NHOA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NHOA_ECOLI inforesidue swissprot:NHOA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NHOA_ECOLI octanol swissprot:NHOA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NHOA_ECOLI pepcoil swissprot:NHOA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NHOA_ECOLI pepdigest swissprot:NHOA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NHOA_ECOLI pepinfo swissprot:NHOA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NHOA_ECOLI pepnet swissprot:NHOA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NHOA_ECOLI pepstats swissprot:NHOA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NHOA_ECOLI pepwheel swissprot:NHOA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NHOA_ECOLI pepwindow swissprot:NHOA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NHOA_ECOLI sigcleave swissprot:NHOA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NHOA_ECOLI ## Database ID URL or Descriptions # AltName QUEF_ECOLI 7-cyano-7-carbaguanine reductase # AltName QUEF_ECOLI NADPH-dependent nitrile oxidoreductase # AltName QUEF_ECOLI PreQ(0) reductase # BIOPHYSICOCHEMICAL PROPERTIES QUEF_ECOLI Kinetic parameters KM=36 uM for NADPH {ECO 0000269|PubMed 15767583, ECO 0000269|PubMed 23410922, ECO 0000269|PubMed 23595998}; KM=6.0 uM for NADPH {ECO 0000269|PubMed 15767583, ECO 0000269|PubMed 23410922, ECO 0000269|PubMed 23595998}; KM=6.1 uM for 7-cyano-7-deazaguanine {ECO 0000269|PubMed 15767583, ECO 0000269|PubMed 23410922, ECO 0000269|PubMed 23595998}; KM=176 uM for 5-cyanopyrrolo[2,3-d]pyrimidin-4-one {ECO 0000269|PubMed 15767583, ECO 0000269|PubMed 23410922, ECO 0000269|PubMed 23595998}; Note=KM for preQ0 appears to be inferior to 1.5 uM, and kcat is 0.1268 sec(-1) (PubMed 23410922). kcat is 6.5 min(-1) with preQ0 as substrate and 3.6 min(-1) with 5-cyanopyrrolo[2,3- d]pyrimidin-4-one as substrate (PubMed 23595998). {ECO 0000269|PubMed 23410922, ECO 0000269|PubMed 23595998}; pH dependence Optimum pH is 7. Retains less than 20% of activity at pH 9 (PubMed 23410922). {ECO 0000269|PubMed 23410922}; Temperature dependence Optimum temperature is 37 degrees Celsius. Displays a half life of 28.2 hours and 12.8 hours at 37 and 40 degrees Celsius, respectively, but at 50 degrees Celsius the half life time drops to 6 minutes (PubMed 23410922). {ECO 0000269|PubMed 23410922}; # BRENDA 1.7.1.13 2026 # BioGrid 4262149 24 # CATALYTIC ACTIVITY QUEF_ECOLI 7-aminomethyl-7-carbaguanine + 2 NADP(+) = 7- cyano-7-carbaguanine + 2 NADPH. {ECO 0000269|PubMed 23410922, ECO 0000269|PubMed 23595998}. # EcoGene EG13173 queF # FUNCTION QUEF_ECOLI Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1), a late step in the queuosine pathway. Is highly specific for its natural substrate preQ0, since it cannot use various aliphatic, aromatic, benzylic and heterocyclic nitriles, such as acetonitrile, benzonitrile, benzylcyanide and 2-cyanopyrrole, although it can reduce the substrate analog 5-cyanopyrrolo[2,3- d]pyrimidin-4-one with lesser efficiency. {ECO 0000269|PubMed 15767583, ECO 0000269|PubMed 23410922, ECO 0000269|PubMed 23595998}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0033739 preQ1 synthase activity; IDA:EcoCyc. # GO_function GO:0046857 oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor; IEA:InterPro. # GO_process GO:0008616 queuosine biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # HAMAP MF_00817 QueF_type2 # IntAct Q46920 6 # InterPro IPR016428 QueF_type2 # InterPro IPR029139 QueF_N # InterPro IPR029500 QueF # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # Organism QUEF_ECOLI Escherichia coli (strain K12) # PATHWAY QUEF_ECOLI tRNA modification; tRNA-queuosine biosynthesis. # PATRIC 32121004 VBIEscCol129921_2894 # PIR F65061 F65061 # PIRSF PIRSF004750 Nitrile_oxidored_YqcD_prd # Pfam PF14489 QueF # Pfam PF14819 QueF_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName QUEF_ECOLI NADPH-dependent 7-cyano-7-deazaguanine reductase # RefSeq NP_417274 NC_000913.3 # RefSeq WP_000100421 NZ_LN832404.1 # SIMILARITY Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION QUEF_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 15767583}. # TIGRFAMs TIGR03138 QueF # eggNOG COG0780 LUCA # eggNOG COG2904 LUCA # eggNOG ENOG4107R1K Bacteria BLAST swissprot:QUEF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:QUEF_ECOLI BioCyc ECOL316407:JW2765-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2765-MONOMER BioCyc EcoCyc:G7452-MONOMER http://biocyc.org/getid?id=EcoCyc:G7452-MONOMER BioCyc MetaCyc:G7452-MONOMER http://biocyc.org/getid?id=MetaCyc:G7452-MONOMER COG COG0780 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0780 COG COG2904 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2904 DIP DIP-12848N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12848N DOI 10.1002/chem.201300163 http://dx.doi.org/10.1002/chem.201300163 DOI 10.1016/j.enzmictec.2012.12.003 http://dx.doi.org/10.1016/j.enzmictec.2012.12.003 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0408056102 http://dx.doi.org/10.1073/pnas.0408056102 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.7.1.13 http://www.genome.jp/dbget-bin/www_bget?EC:1.7.1.13 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 ENZYME 1.7.1.13 http://enzyme.expasy.org/EC/1.7.1.13 EchoBASE EB2965 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2965 EcoGene EG13173 http://www.ecogene.org/geneInfo.php?eg_id=EG13173 EnsemblBacteria AAC75836 http://www.ensemblgenomes.org/id/AAC75836 EnsemblBacteria AAC75836 http://www.ensemblgenomes.org/id/AAC75836 EnsemblBacteria BAE76866 http://www.ensemblgenomes.org/id/BAE76866 EnsemblBacteria BAE76866 http://www.ensemblgenomes.org/id/BAE76866 EnsemblBacteria BAE76866 http://www.ensemblgenomes.org/id/BAE76866 EnsemblBacteria b2794 http://www.ensemblgenomes.org/id/b2794 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0033739 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033739 GO_function GO:0046857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046857 GO_process GO:0008616 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008616 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 947270 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947270 HAMAP MF_00817 http://hamap.expasy.org/unirule/MF_00817 HOGENOM HOG000273755 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000273755&db=HOGENOM6 InParanoid Q46920 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46920 IntAct Q46920 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46920* IntEnz 1.7.1.13 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.7.1.13 InterPro IPR016428 http://www.ebi.ac.uk/interpro/entry/IPR016428 InterPro IPR029139 http://www.ebi.ac.uk/interpro/entry/IPR029139 InterPro IPR029500 http://www.ebi.ac.uk/interpro/entry/IPR029500 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW2765 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2765 KEGG_Gene eco:b2794 http://www.genome.jp/dbget-bin/www_bget?eco:b2794 KEGG_Orthology KO:K06879 http://www.genome.jp/dbget-bin/www_bget?KO:K06879 MINT MINT-1288325 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1288325 OMA QCVERIY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QCVERIY PSORT swissprot:QUEF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:QUEF_ECOLI PSORT-B swissprot:QUEF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:QUEF_ECOLI PSORT2 swissprot:QUEF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:QUEF_ECOLI Pfam PF14489 http://pfam.xfam.org/family/PF14489 Pfam PF14819 http://pfam.xfam.org/family/PF14819 Phobius swissprot:QUEF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:QUEF_ECOLI ProteinModelPortal Q46920 http://www.proteinmodelportal.org/query/uniprot/Q46920 PubMed 15767583 http://www.ncbi.nlm.nih.gov/pubmed/15767583 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 23410922 http://www.ncbi.nlm.nih.gov/pubmed/23410922 PubMed 23595998 http://www.ncbi.nlm.nih.gov/pubmed/23595998 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417274 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417274 RefSeq WP_000100421 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000100421 SMR Q46920 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46920 STRING 511145.b2794 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2794&targetmode=cogs STRING COG0780 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0780&targetmode=cogs STRING COG2904 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2904&targetmode=cogs TIGRFAMs TIGR03138 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03138 UniProtKB QUEF_ECOLI http://www.uniprot.org/uniprot/QUEF_ECOLI UniProtKB-AC Q46920 http://www.uniprot.org/uniprot/Q46920 charge swissprot:QUEF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:QUEF_ECOLI eggNOG COG0780 http://eggnogapi.embl.de/nog_data/html/tree/COG0780 eggNOG COG2904 http://eggnogapi.embl.de/nog_data/html/tree/COG2904 eggNOG ENOG4107R1K http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107R1K epestfind swissprot:QUEF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:QUEF_ECOLI garnier swissprot:QUEF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:QUEF_ECOLI helixturnhelix swissprot:QUEF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:QUEF_ECOLI hmoment swissprot:QUEF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:QUEF_ECOLI iep swissprot:QUEF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:QUEF_ECOLI inforesidue swissprot:QUEF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:QUEF_ECOLI octanol swissprot:QUEF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:QUEF_ECOLI pepcoil swissprot:QUEF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:QUEF_ECOLI pepdigest swissprot:QUEF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:QUEF_ECOLI pepinfo swissprot:QUEF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:QUEF_ECOLI pepnet swissprot:QUEF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:QUEF_ECOLI pepstats swissprot:QUEF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:QUEF_ECOLI pepwheel swissprot:QUEF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:QUEF_ECOLI pepwindow swissprot:QUEF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:QUEF_ECOLI sigcleave swissprot:QUEF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:QUEF_ECOLI ## Database ID URL or Descriptions # BioGrid 4260614 16 # EcoGene EG14226 ypjD # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0020037 heme binding; IEA:InterPro. # GO_process GO:0017004 cytochrome complex assembly; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006461 protein complex assembly # InterPro IPR002541 Cyt_c_assembly # Organism YPJD_ECOLI Escherichia coli (strain K12) # PATRIC 32120621 VBIEscCol129921_2709 # PIR F65039 F65039 # Pfam PF01578 Cytochrom_C_asm # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YPJD_ECOLI Inner membrane protein YpjD # RefSeq NP_417102 NC_000913.3 # RefSeq WP_001338897 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAE76757.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SUBCELLULAR LOCATION YPJD_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 9.B.14.3 the putative heme handling protein (hhp) family # eggNOG COG4137 LUCA # eggNOG ENOG4106KVJ Bacteria BLAST swissprot:YPJD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YPJD_ECOLI BioCyc ECOL316407:JW2592-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2592-MONOMER BioCyc EcoCyc:G7355-MONOMER http://biocyc.org/getid?id=EcoCyc:G7355-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3978 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3978 EcoGene EG14226 http://www.ecogene.org/geneInfo.php?eg_id=EG14226 EnsemblBacteria AAC75660 http://www.ensemblgenomes.org/id/AAC75660 EnsemblBacteria AAC75660 http://www.ensemblgenomes.org/id/AAC75660 EnsemblBacteria BAE76757 http://www.ensemblgenomes.org/id/BAE76757 EnsemblBacteria BAE76757 http://www.ensemblgenomes.org/id/BAE76757 EnsemblBacteria BAE76757 http://www.ensemblgenomes.org/id/BAE76757 EnsemblBacteria b2611 http://www.ensemblgenomes.org/id/b2611 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0020037 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0020037 GO_process GO:0017004 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017004 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GeneID 947098 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947098 HOGENOM HOG000255940 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000255940&db=HOGENOM6 InParanoid P64432 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P64432 InterPro IPR002541 http://www.ebi.ac.uk/interpro/entry/IPR002541 KEGG_Gene ecj:JW2592 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2592 KEGG_Gene eco:b2611 http://www.genome.jp/dbget-bin/www_bget?eco:b2611 OMA MPPLMTV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MPPLMTV PSORT swissprot:YPJD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YPJD_ECOLI PSORT-B swissprot:YPJD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YPJD_ECOLI PSORT2 swissprot:YPJD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YPJD_ECOLI Pfam PF01578 http://pfam.xfam.org/family/PF01578 Phobius swissprot:YPJD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YPJD_ECOLI ProteinModelPortal P64432 http://www.proteinmodelportal.org/query/uniprot/P64432 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417102 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417102 RefSeq WP_001338897 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001338897 STRING 511145.b2611 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2611&targetmode=cogs TCDB 9.B.14.3 http://www.tcdb.org/search/result.php?tc=9.B.14.3 UniProtKB YPJD_ECOLI http://www.uniprot.org/uniprot/YPJD_ECOLI UniProtKB-AC P64432 http://www.uniprot.org/uniprot/P64432 charge swissprot:YPJD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YPJD_ECOLI eggNOG COG4137 http://eggnogapi.embl.de/nog_data/html/tree/COG4137 eggNOG ENOG4106KVJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106KVJ epestfind swissprot:YPJD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YPJD_ECOLI garnier swissprot:YPJD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YPJD_ECOLI helixturnhelix swissprot:YPJD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YPJD_ECOLI hmoment swissprot:YPJD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YPJD_ECOLI iep swissprot:YPJD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YPJD_ECOLI inforesidue swissprot:YPJD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YPJD_ECOLI octanol swissprot:YPJD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YPJD_ECOLI pepcoil swissprot:YPJD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YPJD_ECOLI pepdigest swissprot:YPJD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YPJD_ECOLI pepinfo swissprot:YPJD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YPJD_ECOLI pepnet swissprot:YPJD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YPJD_ECOLI pepstats swissprot:YPJD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YPJD_ECOLI pepwheel swissprot:YPJD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YPJD_ECOLI pepwindow swissprot:YPJD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YPJD_ECOLI sigcleave swissprot:YPJD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YPJD_ECOLI ## Database ID URL or Descriptions # BioGrid 4261737 14 # CDD cd07377 WHTH_GntR # EcoGene EG13820 rspR # FUNCTION RSPR_ECOLI Repressor of the rspAB operon. Acts by binding directly to the upstream region of rspA. {ECO 0000269|PubMed 22972332}. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; ISS:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # Gene3D 1.20.120.530 -; 1. # IntAct P0ACM2 2 # InterPro IPR000524 Tscrpt_reg_HTH_GntR # InterPro IPR008920 TF_FadR/GntR_C # InterPro IPR011711 GntR_C # InterPro IPR011991 WHTH_DNA-bd_dom # Organism RSPR_ECOLI Escherichia coli (strain K12) # PATRIC 32118380 VBIEscCol129921_1610 # PIR G64908 G64908 # PRINTS PR00035 HTHGNTR # PROSITE PS50949 HTH_GNTR # Pfam PF00392 GntR # Pfam PF07729 FCD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RSPR_ECOLI HTH-type transcriptional repressor RspR # RefSeq NP_416058 NC_000913.3 # RefSeq WP_000215549 NZ_LN832404.1 # SIMILARITY Contains 1 HTH gntR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00307}. # SMART SM00345 HTH_GNTR # SMART SM00895 FCD # SUPFAM SSF46785 SSF46785 # SUPFAM SSF48008 SSF48008 # eggNOG COG1802 LUCA # eggNOG ENOG4107XBN Bacteria BLAST swissprot:RSPR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RSPR_ECOLI BioCyc ECOL316407:JW1533-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1533-MONOMER BioCyc EcoCyc:G6814-MONOMER http://biocyc.org/getid?id=EcoCyc:G6814-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1271/bbb.120273 http://dx.doi.org/10.1271/bbb.120273 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3581 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3581 EcoGene EG13820 http://www.ecogene.org/geneInfo.php?eg_id=EG13820 EnsemblBacteria AAC74613 http://www.ensemblgenomes.org/id/AAC74613 EnsemblBacteria AAC74613 http://www.ensemblgenomes.org/id/AAC74613 EnsemblBacteria BAA15242 http://www.ensemblgenomes.org/id/BAA15242 EnsemblBacteria BAA15242 http://www.ensemblgenomes.org/id/BAA15242 EnsemblBacteria BAA15242 http://www.ensemblgenomes.org/id/BAA15242 EnsemblBacteria b1540 http://www.ensemblgenomes.org/id/b1540 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 1.20.120.530 http://www.cathdb.info/version/latest/superfamily/1.20.120.530 GeneID 946087 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946087 HOGENOM HOG000273994 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000273994&db=HOGENOM6 InParanoid P0ACM2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACM2 IntAct P0ACM2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACM2* InterPro IPR000524 http://www.ebi.ac.uk/interpro/entry/IPR000524 InterPro IPR008920 http://www.ebi.ac.uk/interpro/entry/IPR008920 InterPro IPR011711 http://www.ebi.ac.uk/interpro/entry/IPR011711 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW1533 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1533 KEGG_Gene eco:b1540 http://www.genome.jp/dbget-bin/www_bget?eco:b1540 OMA VECTIPP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VECTIPP PRINTS PR00035 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00035 PROSITE PS50949 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50949 PSORT swissprot:RSPR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RSPR_ECOLI PSORT-B swissprot:RSPR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RSPR_ECOLI PSORT2 swissprot:RSPR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RSPR_ECOLI Pfam PF00392 http://pfam.xfam.org/family/PF00392 Pfam PF07729 http://pfam.xfam.org/family/PF07729 Phobius swissprot:RSPR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RSPR_ECOLI PhylomeDB P0ACM2 http://phylomedb.org/?seqid=P0ACM2 ProteinModelPortal P0ACM2 http://www.proteinmodelportal.org/query/uniprot/P0ACM2 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22972332 http://www.ncbi.nlm.nih.gov/pubmed/22972332 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416058 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416058 RefSeq WP_000215549 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000215549 SMART SM00345 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00345 SMART SM00895 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00895 SMR P0ACM2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACM2 STRING 511145.b1540 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1540&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SUPFAM SSF48008 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48008 UniProtKB RSPR_ECOLI http://www.uniprot.org/uniprot/RSPR_ECOLI UniProtKB-AC P0ACM2 http://www.uniprot.org/uniprot/P0ACM2 charge swissprot:RSPR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RSPR_ECOLI eggNOG COG1802 http://eggnogapi.embl.de/nog_data/html/tree/COG1802 eggNOG ENOG4107XBN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107XBN epestfind swissprot:RSPR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RSPR_ECOLI garnier swissprot:RSPR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RSPR_ECOLI helixturnhelix swissprot:RSPR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RSPR_ECOLI hmoment swissprot:RSPR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RSPR_ECOLI iep swissprot:RSPR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RSPR_ECOLI inforesidue swissprot:RSPR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RSPR_ECOLI octanol swissprot:RSPR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RSPR_ECOLI pepcoil swissprot:RSPR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RSPR_ECOLI pepdigest swissprot:RSPR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RSPR_ECOLI pepinfo swissprot:RSPR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RSPR_ECOLI pepnet swissprot:RSPR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RSPR_ECOLI pepstats swissprot:RSPR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RSPR_ECOLI pepwheel swissprot:RSPR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RSPR_ECOLI pepwindow swissprot:RSPR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RSPR_ECOLI sigcleave swissprot:RSPR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RSPR_ECOLI ## Database ID URL or Descriptions # BioGrid 4259320 6 # EcoGene EG12342 yjjJ # GO_function GO:0016301 kinase activity; IEA:UniProtKB-KW. # GOslim_function GO:0016301 kinase activity # IntAct P39410 2 # InterPro IPR012893 HipA-like_C # InterPro IPR012894 HipA_N2 # Organism YJJJ_ECOLI Escherichia coli (strain K12) # PATRIC 32124386 VBIEscCol129921_4533 # PIR S56609 S56609 # Pfam PF07804 HipA_C # Pfam PF07805 HipA_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJJJ_ECOLI Putative kinase YjjJ # RefSeq NP_418802 NC_000913.3 # RefSeq WP_001293115 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA29115.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA29115.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the HipA Ser/Thr kinase family. {ECO 0000305}. # eggNOG ENOG4105EUP Bacteria # eggNOG ENOG410XRIH LUCA BLAST swissprot:YJJJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJJJ_ECOLI BioCyc ECOL316407:JW4348-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4348-MONOMER BioCyc EcoCyc:EG12342-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12342-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/15.13.5125 http://dx.doi.org/10.1093/nar/15.13.5125 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:2.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X05629 http://www.ebi.ac.uk/ena/data/view/X05629 ENZYME 2.-.-.- http://enzyme.expasy.org/EC/2.-.-.- EchoBASE EB2246 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2246 EcoGene EG12342 http://www.ecogene.org/geneInfo.php?eg_id=EG12342 EnsemblBacteria AAC77338 http://www.ensemblgenomes.org/id/AAC77338 EnsemblBacteria AAC77338 http://www.ensemblgenomes.org/id/AAC77338 EnsemblBacteria BAE78374 http://www.ensemblgenomes.org/id/BAE78374 EnsemblBacteria BAE78374 http://www.ensemblgenomes.org/id/BAE78374 EnsemblBacteria BAE78374 http://www.ensemblgenomes.org/id/BAE78374 EnsemblBacteria b4385 http://www.ensemblgenomes.org/id/b4385 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GeneID 944883 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944883 HOGENOM HOG000127842 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000127842&db=HOGENOM6 InParanoid P39410 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39410 IntAct P39410 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39410* IntEnz 2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2 InterPro IPR012893 http://www.ebi.ac.uk/interpro/entry/IPR012893 InterPro IPR012894 http://www.ebi.ac.uk/interpro/entry/IPR012894 KEGG_Gene ecj:JW4348 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4348 KEGG_Gene eco:b4385 http://www.genome.jp/dbget-bin/www_bget?eco:b4385 OMA DLLVCEH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DLLVCEH PSORT swissprot:YJJJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJJJ_ECOLI PSORT-B swissprot:YJJJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJJJ_ECOLI PSORT2 swissprot:YJJJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJJJ_ECOLI Pfam PF07804 http://pfam.xfam.org/family/PF07804 Pfam PF07805 http://pfam.xfam.org/family/PF07805 Phobius swissprot:YJJJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJJJ_ECOLI ProteinModelPortal P39410 http://www.proteinmodelportal.org/query/uniprot/P39410 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3299264 http://www.ncbi.nlm.nih.gov/pubmed/3299264 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418802 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418802 RefSeq WP_001293115 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001293115 STRING 511145.b4385 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4385&targetmode=cogs UniProtKB YJJJ_ECOLI http://www.uniprot.org/uniprot/YJJJ_ECOLI UniProtKB-AC P39410 http://www.uniprot.org/uniprot/P39410 charge swissprot:YJJJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJJJ_ECOLI eggNOG ENOG4105EUP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EUP eggNOG ENOG410XRIH http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRIH epestfind swissprot:YJJJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJJJ_ECOLI garnier swissprot:YJJJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJJJ_ECOLI helixturnhelix swissprot:YJJJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJJJ_ECOLI hmoment swissprot:YJJJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJJJ_ECOLI iep swissprot:YJJJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJJJ_ECOLI inforesidue swissprot:YJJJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJJJ_ECOLI octanol swissprot:YJJJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJJJ_ECOLI pepcoil swissprot:YJJJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJJJ_ECOLI pepdigest swissprot:YJJJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJJJ_ECOLI pepinfo swissprot:YJJJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJJJ_ECOLI pepnet swissprot:YJJJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJJJ_ECOLI pepstats swissprot:YJJJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJJJ_ECOLI pepwheel swissprot:YJJJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJJJ_ECOLI pepwindow swissprot:YJJJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJJJ_ECOLI sigcleave swissprot:YJJJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJJJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4261333 197 # DISRUPTION PHENOTYPE Cells lose the inability to form colonies at 42 degrees Celsius. At 43 degrees Celsius, htrC mutant bacteria gradually lyse, whereas at intermediate temperatures they filament extensively. {ECO:0000269|PubMed 2160943}. # EcoGene EG11429 htrC # Organism HTRC_ECOLI Escherichia coli (strain K12) # PATRIC 32123499 VBIEscCol129921_4102 # PIR H65205 H65205 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HTRC_ECOLI Heat shock protein C # RefSeq NP_418416 NC_000913.3 # RefSeq WP_001307500 NZ_LN832404.1 # eggNOG ENOG410645W Bacteria # eggNOG ENOG4112D5I LUCA BLAST swissprot:HTRC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HTRC_ECOLI BioCyc ECOL316407:JW3952-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3952-MONOMER BioCyc EcoCyc:EG11429-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11429-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00339 http://www.ebi.ac.uk/ena/data/view/V00339 EchoBASE EB1399 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1399 EcoGene EG11429 http://www.ecogene.org/geneInfo.php?eg_id=EG11429 EnsemblBacteria AAC76963 http://www.ensemblgenomes.org/id/AAC76963 EnsemblBacteria AAC76963 http://www.ensemblgenomes.org/id/AAC76963 EnsemblBacteria BAE77331 http://www.ensemblgenomes.org/id/BAE77331 EnsemblBacteria BAE77331 http://www.ensemblgenomes.org/id/BAE77331 EnsemblBacteria BAE77331 http://www.ensemblgenomes.org/id/BAE77331 EnsemblBacteria b3989 http://www.ensemblgenomes.org/id/b3989 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 948495 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948495 HOGENOM HOG000009660 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009660&db=HOGENOM6 KEGG_Gene ecj:JW3952 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3952 KEGG_Gene eco:b3989 http://www.genome.jp/dbget-bin/www_bget?eco:b3989 OMA KSIMTPT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KSIMTPT PSORT swissprot:HTRC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HTRC_ECOLI PSORT-B swissprot:HTRC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HTRC_ECOLI PSORT2 swissprot:HTRC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HTRC_ECOLI Phobius swissprot:HTRC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HTRC_ECOLI ProteinModelPortal P27375 http://www.proteinmodelportal.org/query/uniprot/P27375 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2160943 http://www.ncbi.nlm.nih.gov/pubmed/2160943 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418416 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418416 RefSeq WP_001307500 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001307500 STRING 511145.b3989 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3989&targetmode=cogs UniProtKB HTRC_ECOLI http://www.uniprot.org/uniprot/HTRC_ECOLI UniProtKB-AC P27375 http://www.uniprot.org/uniprot/P27375 charge swissprot:HTRC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HTRC_ECOLI eggNOG ENOG410645W http://eggnogapi.embl.de/nog_data/html/tree/ENOG410645W eggNOG ENOG4112D5I http://eggnogapi.embl.de/nog_data/html/tree/ENOG4112D5I epestfind swissprot:HTRC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HTRC_ECOLI garnier swissprot:HTRC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HTRC_ECOLI helixturnhelix swissprot:HTRC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HTRC_ECOLI hmoment swissprot:HTRC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HTRC_ECOLI iep swissprot:HTRC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HTRC_ECOLI inforesidue swissprot:HTRC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HTRC_ECOLI octanol swissprot:HTRC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HTRC_ECOLI pepcoil swissprot:HTRC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HTRC_ECOLI pepdigest swissprot:HTRC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HTRC_ECOLI pepinfo swissprot:HTRC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HTRC_ECOLI pepnet swissprot:HTRC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HTRC_ECOLI pepstats swissprot:HTRC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HTRC_ECOLI pepwheel swissprot:HTRC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HTRC_ECOLI pepwindow swissprot:HTRC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HTRC_ECOLI sigcleave swissprot:HTRC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HTRC_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES CPDA_ECOLI Kinetic parameters KM=0.5 mM for cAMP {ECO 0000269|PubMed 8810311}; Vmax=2.0 umol/min/mg enzyme {ECO 0000269|PubMed 8810311}; # BioGrid 4262395 9 # CATALYTIC ACTIVITY CPDA_ECOLI Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate. {ECO 0000255|HAMAP-Rule MF_00905, ECO 0000269|PubMed 8810311}. # CDD cd07402 MPP_GpdQ # COFACTOR CPDA_ECOLI Name=a metal cation; Xref=ChEBI CHEBI 25213; Evidence={ECO 0000255|HAMAP-Rule MF_00905}; Note=Binds 2 metal cations per subunit. {ECO 0000255|HAMAP- Rule MF_00905}; # ENZYME REGULATION Activated by iron. {ECO:0000269|PubMed 8810311}. # EcoGene EG12187 cpdA # FUNCTION CPDA_ECOLI Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. Specific for cAMP. {ECO 0000255|HAMAP-Rule MF_00905, ECO 0000269|PubMed 8810311}. # GO_function GO:0000166 nucleotide binding; IEA:UniProtKB-HAMAP. # GO_function GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity; IDA:EcoCyc. # GO_function GO:0008198 ferrous iron binding; IDA:EcoCyc. # GO_process GO:0042545 cell wall modification; IBA:GO_Central. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 3.60.21.10 -; 1. # HAMAP MF_00905 cAMP_phophodiest_CpdA # IntAct P0AEW4 10 # InterPro IPR004843 Calcineurin-like_PHP_ApaH # InterPro IPR013622 CpdA_C # InterPro IPR026575 cAMP_Pdiest_CpdA # InterPro IPR029052 Metallo-depent_PP-like # Organism CPDA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR12905:SF7 PTHR12905:SF7; 2 # PATRIC 32121474 VBIEscCol129921_3124 # PIR F65090 F65090 # Pfam PF00149 Metallophos # ProDom PD587589 Calcineurin-like_phos_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA {ECO:0000255|HAMAP-Rule MF_00905} # RefSeq NP_417504 NC_000913.3 # RefSeq WP_000444747 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA69200.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the cAMP phosphodiesterase class-III family. {ECO:0000255|HAMAP-Rule MF_00905}. # SUPFAM SSF56300 SSF56300 # eggNOG COG1409 LUCA # eggNOG ENOG41070EG Bacteria BLAST swissprot:CPDA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CPDA_ECOLI BioCyc ECOL316407:JW3000-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3000-MONOMER BioCyc EcoCyc:G7579-MONOMER http://biocyc.org/getid?id=EcoCyc:G7579-MONOMER BioCyc MetaCyc:G7579-MONOMER http://biocyc.org/getid?id=MetaCyc:G7579-MONOMER COG COG1409 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1409 DOI 10.1002/prot.10049 http://dx.doi.org/10.1002/prot.10049 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.271.41.25423 http://dx.doi.org/10.1074/jbc.271.41.25423 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.4.53 {ECO:0000255|HAMAP-Rule:MF_00905} http://www.genome.jp/dbget-bin/www_bget?EC:3.1.4.53 {ECO:0000255|HAMAP-Rule:MF_00905} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D16557 http://www.ebi.ac.uk/ena/data/view/D16557 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 ENZYME 3.1.4.53 {ECO:0000255|HAMAP-Rule:MF_00905} http://enzyme.expasy.org/EC/3.1.4.53 {ECO:0000255|HAMAP-Rule:MF_00905} EchoBASE EB2104 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2104 EcoGene EG12187 http://www.ecogene.org/geneInfo.php?eg_id=EG12187 EnsemblBacteria AAC76068 http://www.ensemblgenomes.org/id/AAC76068 EnsemblBacteria AAC76068 http://www.ensemblgenomes.org/id/AAC76068 EnsemblBacteria BAE77088 http://www.ensemblgenomes.org/id/BAE77088 EnsemblBacteria BAE77088 http://www.ensemblgenomes.org/id/BAE77088 EnsemblBacteria BAE77088 http://www.ensemblgenomes.org/id/BAE77088 EnsemblBacteria b3032 http://www.ensemblgenomes.org/id/b3032 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000166 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000166 GO_function GO:0004115 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004115 GO_function GO:0008198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008198 GO_process GO:0042545 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042545 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 3.60.21.10 http://www.cathdb.info/version/latest/superfamily/3.60.21.10 GeneID 947515 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947515 HAMAP MF_00905 http://hamap.expasy.org/unirule/MF_00905 HOGENOM HOG000238351 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000238351&db=HOGENOM6 InParanoid P0AEW4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEW4 IntAct P0AEW4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEW4* IntEnz 3.1.4.53 {ECO:0000255|HAMAP-Rule:MF_00905} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.4.53 {ECO:0000255|HAMAP-Rule:MF_00905} InterPro IPR004843 http://www.ebi.ac.uk/interpro/entry/IPR004843 InterPro IPR013622 http://www.ebi.ac.uk/interpro/entry/IPR013622 InterPro IPR026575 http://www.ebi.ac.uk/interpro/entry/IPR026575 InterPro IPR029052 http://www.ebi.ac.uk/interpro/entry/IPR029052 KEGG_Gene ecj:JW3000 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3000 KEGG_Gene eco:b3032 http://www.genome.jp/dbget-bin/www_bget?eco:b3032 KEGG_Orthology KO:K03651 http://www.genome.jp/dbget-bin/www_bget?KO:K03651 OMA DPHLFKD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DPHLFKD PANTHER PTHR12905:SF7 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12905:SF7 PSORT swissprot:CPDA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CPDA_ECOLI PSORT-B swissprot:CPDA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CPDA_ECOLI PSORT2 swissprot:CPDA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CPDA_ECOLI Pfam PF00149 http://pfam.xfam.org/family/PF00149 Phobius swissprot:CPDA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CPDA_ECOLI PhylomeDB P0AEW4 http://phylomedb.org/?seqid=P0AEW4 ProteinModelPortal P0AEW4 http://www.proteinmodelportal.org/query/uniprot/P0AEW4 PubMed 11835503 http://www.ncbi.nlm.nih.gov/pubmed/11835503 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8810311 http://www.ncbi.nlm.nih.gov/pubmed/8810311 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417504 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417504 RefSeq WP_000444747 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000444747 SMR P0AEW4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEW4 STRING 511145.b3032 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3032&targetmode=cogs STRING COG1409 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1409&targetmode=cogs SUPFAM SSF56300 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56300 UniProtKB CPDA_ECOLI http://www.uniprot.org/uniprot/CPDA_ECOLI UniProtKB-AC P0AEW4 http://www.uniprot.org/uniprot/P0AEW4 charge swissprot:CPDA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CPDA_ECOLI eggNOG COG1409 http://eggnogapi.embl.de/nog_data/html/tree/COG1409 eggNOG ENOG41070EG http://eggnogapi.embl.de/nog_data/html/tree/ENOG41070EG epestfind swissprot:CPDA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CPDA_ECOLI garnier swissprot:CPDA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CPDA_ECOLI helixturnhelix swissprot:CPDA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CPDA_ECOLI hmoment swissprot:CPDA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CPDA_ECOLI iep swissprot:CPDA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CPDA_ECOLI inforesidue swissprot:CPDA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CPDA_ECOLI octanol swissprot:CPDA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CPDA_ECOLI pepcoil swissprot:CPDA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CPDA_ECOLI pepdigest swissprot:CPDA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CPDA_ECOLI pepinfo swissprot:CPDA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CPDA_ECOLI pepnet swissprot:CPDA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CPDA_ECOLI pepstats swissprot:CPDA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CPDA_ECOLI pepwheel swissprot:CPDA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CPDA_ECOLI pepwindow swissprot:CPDA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CPDA_ECOLI sigcleave swissprot:CPDA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CPDA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262756 6 # COFACTOR YJIL_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000305}; Note=Binds 1 [4Fe-4S] cluster per dimer. {ECO 0000305}; # EcoGene EG12573 yjiL # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # InterPro IPR002731 ATPase_BadF # InterPro IPR008275 CoA_E_activase # Organism YJIL_ECOLI Escherichia coli (strain K12) # PATRIC 32124274 VBIEscCol129921_4480 # PIR S56559 S56559 # Pfam PF01869 BcrAD_BadFG # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJIL_ECOLI Uncharacterized protein YjiL # RefSeq NP_418754 NC_000913.3 # RefSeq WP_000331745 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97230.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SUBUNIT Homodimer. {ECO 0000305}. # TIGRFAMs TIGR00241 CoA_E_activ # eggNOG COG1924 LUCA # eggNOG ENOG4105CIZ Bacteria BLAST swissprot:YJIL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJIL_ECOLI BioCyc ECOL316407:JW5785-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5785-MONOMER BioCyc EcoCyc:G7931-MONOMER http://biocyc.org/getid?id=EcoCyc:G7931-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2461 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2461 EcoGene EG12573 http://www.ecogene.org/geneInfo.php?eg_id=EG12573 EnsemblBacteria AAC77290 http://www.ensemblgenomes.org/id/AAC77290 EnsemblBacteria AAC77290 http://www.ensemblgenomes.org/id/AAC77290 EnsemblBacteria BAE78327 http://www.ensemblgenomes.org/id/BAE78327 EnsemblBacteria BAE78327 http://www.ensemblgenomes.org/id/BAE78327 EnsemblBacteria BAE78327 http://www.ensemblgenomes.org/id/BAE78327 EnsemblBacteria b4334 http://www.ensemblgenomes.org/id/b4334 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GeneID 948837 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948837 HOGENOM HOG000282733 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000282733&db=HOGENOM6 InParanoid P39383 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39383 InterPro IPR002731 http://www.ebi.ac.uk/interpro/entry/IPR002731 InterPro IPR008275 http://www.ebi.ac.uk/interpro/entry/IPR008275 KEGG_Gene ecj:JW5785 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5785 KEGG_Gene eco:b4334 http://www.genome.jp/dbget-bin/www_bget?eco:b4334 OMA FENIHRC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FENIHRC PSORT swissprot:YJIL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJIL_ECOLI PSORT-B swissprot:YJIL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJIL_ECOLI PSORT2 swissprot:YJIL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJIL_ECOLI Pfam PF01869 http://pfam.xfam.org/family/PF01869 Phobius swissprot:YJIL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJIL_ECOLI PhylomeDB P39383 http://phylomedb.org/?seqid=P39383 ProteinModelPortal P39383 http://www.proteinmodelportal.org/query/uniprot/P39383 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418754 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418754 RefSeq WP_000331745 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000331745 SMR P39383 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39383 STRING 511145.b4334 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4334&targetmode=cogs TIGRFAMs TIGR00241 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00241 UniProtKB YJIL_ECOLI http://www.uniprot.org/uniprot/YJIL_ECOLI UniProtKB-AC P39383 http://www.uniprot.org/uniprot/P39383 charge swissprot:YJIL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJIL_ECOLI eggNOG COG1924 http://eggnogapi.embl.de/nog_data/html/tree/COG1924 eggNOG ENOG4105CIZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CIZ epestfind swissprot:YJIL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJIL_ECOLI garnier swissprot:YJIL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJIL_ECOLI helixturnhelix swissprot:YJIL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJIL_ECOLI hmoment swissprot:YJIL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJIL_ECOLI iep swissprot:YJIL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJIL_ECOLI inforesidue swissprot:YJIL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJIL_ECOLI octanol swissprot:YJIL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJIL_ECOLI pepcoil swissprot:YJIL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJIL_ECOLI pepdigest swissprot:YJIL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJIL_ECOLI pepinfo swissprot:YJIL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJIL_ECOLI pepnet swissprot:YJIL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJIL_ECOLI pepstats swissprot:YJIL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJIL_ECOLI pepwheel swissprot:YJIL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJIL_ECOLI pepwindow swissprot:YJIL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJIL_ECOLI sigcleave swissprot:YJIL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJIL_ECOLI ## Database ID URL or Descriptions # AltName MURD_ECOLI D-glutamic acid-adding enzyme # AltName MURD_ECOLI UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase # BRENDA 6.3.2 2026 # BioGrid 4261477 565 # CATALYTIC ACTIVITY MURD_ECOLI ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanine + D-glutamate = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L- alanyl-D-glutamate. # EcoGene EG10620 murD # FUNCTION MURD_ECOLI Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008764 UDP-N-acetylmuramoylalanine-D-glutamate ligase activity; IDA:EcoCyc. # GO_process GO:0007049 cell cycle; IEA:UniProtKB-KW. # GO_process GO:0008360 regulation of cell shape; IEA:UniProtKB-KW. # GO_process GO:0009252 peptidoglycan biosynthetic process; IDA:EcoCyc. # GO_process GO:0051301 cell division; IEA:UniProtKB-KW. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0007049 cell cycle # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0051301 cell division # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 3.40.1190.10 -; 1. # Gene3D 3.40.50.720 -; 1. # Gene3D 3.90.190.20 -; 1. # HAMAP MF_00639 MurD # INTERACTION MURD_ECOLI Self; NbExp=3; IntAct=EBI-554780, EBI-554780; # IntAct P14900 8 # InterPro IPR004101 Mur_ligase_C # InterPro IPR005762 UDP-N-AcMur-Glu_ligase # InterPro IPR013221 Mur_ligase_cen # InterPro IPR016040 NAD(P)-bd_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00471 D-Glutamine and D-glutamate metabolism # KEGG_Pathway ko00550 Peptidoglycan biosynthesis # Organism MURD_ECOLI Escherichia coli (strain K12) # PATHWAY MURD_ECOLI Cell wall biogenesis; peptidoglycan biosynthesis. # PATRIC 32115281 VBIEscCol129921_0092 # PDB 1E0D X-ray; 2.40 A; A=2-438 # PDB 1EEH X-ray; 1.90 A; A=2-438 # PDB 1UAG X-ray; 1.95 A; A=2-438 # PDB 2JFF X-ray; 1.89 A; A=2-438 # PDB 2JFG X-ray; 1.52 A; A=2-438 # PDB 2JFH X-ray; 1.97 A; A=2-438 # PDB 2UAG X-ray; 1.70 A; A=2-438 # PDB 2UUO X-ray; 2.50 A; A=2-438 # PDB 2UUP X-ray; 1.88 A; A=2-438 # PDB 2VTD X-ray; 1.94 A; A=1-438 # PDB 2VTE X-ray; 2.20 A; A=1-438 # PDB 2WJP X-ray; 1.60 A; A=2-438 # PDB 2X5O X-ray; 1.46 A; A=2-438 # PDB 2XPC X-ray; 1.49 A; A=2-438 # PDB 2Y1O X-ray; 1.49 A; A=1-438 # PDB 2Y66 X-ray; 1.49 A; A=1-438 # PDB 2Y67 X-ray; 1.85 A; A=1-438 # PDB 2Y68 X-ray; 1.49 A; A=1-438 # PDB 3UAG X-ray; 1.77 A; A=2-438 # PDB 4UAG X-ray; 1.66 A; A=2-438 # PDB 5A5E X-ray; 1.84 A; A=2-438 # PDB 5A5F X-ray; 1.90 A; A=2-438 # PIR S08396 CEECME # Pfam PF02875 Mur_ligase_C # Pfam PF08245 Mur_ligase_M # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MURD_ECOLI UDP-N-acetylmuramoylalanine--D-glutamate ligase # RefSeq NP_414630 NC_000913.3 # RefSeq WP_000796481 NZ_LN832404.1 # SIMILARITY Belongs to the MurCDEF family. {ECO 0000305}. # SUBCELLULAR LOCATION MURD_ECOLI Cytoplasm. # SUPFAM SSF53244 SSF53244 # SUPFAM SSF53623 SSF53623 # TIGRFAMs TIGR01087 murD # eggNOG COG0771 LUCA # eggNOG ENOG4105DMZ Bacteria BLAST swissprot:MURD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MURD_ECOLI BioCyc ECOL316407:JW0086-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0086-MONOMER BioCyc EcoCyc:UDP-NACMURALA-GLU-LIG-MONOMER http://biocyc.org/getid?id=EcoCyc:UDP-NACMURALA-GLU-LIG-MONOMER BioCyc MetaCyc:UDP-NACMURALA-GLU-LIG-MONOMER http://biocyc.org/getid?id=MetaCyc:UDP-NACMURALA-GLU-LIG-MONOMER COG COG0771 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0771 DIP DIP-10279N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10279N DOI 10.1006/jmbi.2000.3994 http://dx.doi.org/10.1006/jmbi.2000.3994 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/emboj/16.12.3416 http://dx.doi.org/10.1093/emboj/16.12.3416 DOI 10.1093/nar/18.1.183 http://dx.doi.org/10.1093/nar/18.1.183 DOI 10.1093/nar/18.4.1058 http://dx.doi.org/10.1093/nar/18.4.1058 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1111/j.1432-1033.1991.tb16486.x http://dx.doi.org/10.1111/j.1432-1033.1991.tb16486.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.3.2.9 http://www.genome.jp/dbget-bin/www_bget?EC:6.3.2.9 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M30807 http://www.ebi.ac.uk/ena/data/view/M30807 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X17609 http://www.ebi.ac.uk/ena/data/view/X17609 EMBL X51584 http://www.ebi.ac.uk/ena/data/view/X51584 EMBL X55034 http://www.ebi.ac.uk/ena/data/view/X55034 ENZYME 6.3.2.9 http://enzyme.expasy.org/EC/6.3.2.9 EchoBASE EB0615 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0615 EcoGene EG10620 http://www.ecogene.org/geneInfo.php?eg_id=EG10620 EnsemblBacteria AAC73199 http://www.ensemblgenomes.org/id/AAC73199 EnsemblBacteria AAC73199 http://www.ensemblgenomes.org/id/AAC73199 EnsemblBacteria BAB96656 http://www.ensemblgenomes.org/id/BAB96656 EnsemblBacteria BAB96656 http://www.ensemblgenomes.org/id/BAB96656 EnsemblBacteria BAB96656 http://www.ensemblgenomes.org/id/BAB96656 EnsemblBacteria b0088 http://www.ensemblgenomes.org/id/b0088 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008764 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008764 GO_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0009252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009252 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 3.40.1190.10 http://www.cathdb.info/version/latest/superfamily/3.40.1190.10 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 Gene3D 3.90.190.20 http://www.cathdb.info/version/latest/superfamily/3.90.190.20 GeneID 944818 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944818 HAMAP MF_00639 http://hamap.expasy.org/unirule/MF_00639 HOGENOM HOG000049427 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000049427&db=HOGENOM6 InParanoid P14900 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P14900 IntAct P14900 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P14900* IntEnz 6.3.2.9 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.2.9 InterPro IPR004101 http://www.ebi.ac.uk/interpro/entry/IPR004101 InterPro IPR005762 http://www.ebi.ac.uk/interpro/entry/IPR005762 InterPro IPR013221 http://www.ebi.ac.uk/interpro/entry/IPR013221 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0086 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0086 KEGG_Gene eco:b0088 http://www.genome.jp/dbget-bin/www_bget?eco:b0088 KEGG_Orthology KO:K01925 http://www.genome.jp/dbget-bin/www_bget?KO:K01925 KEGG_Pathway ko00471 http://www.genome.jp/kegg-bin/show_pathway?ko00471 KEGG_Pathway ko00550 http://www.genome.jp/kegg-bin/show_pathway?ko00550 KEGG_Reaction rn:R02783 http://www.genome.jp/dbget-bin/www_bget?rn:R02783 MINT MINT-1269366 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1269366 OMA PGIPYTN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PGIPYTN PDB 1E0D http://www.ebi.ac.uk/pdbe-srv/view/entry/1E0D PDB 1EEH http://www.ebi.ac.uk/pdbe-srv/view/entry/1EEH PDB 1UAG http://www.ebi.ac.uk/pdbe-srv/view/entry/1UAG PDB 2JFF http://www.ebi.ac.uk/pdbe-srv/view/entry/2JFF PDB 2JFG http://www.ebi.ac.uk/pdbe-srv/view/entry/2JFG PDB 2JFH http://www.ebi.ac.uk/pdbe-srv/view/entry/2JFH PDB 2UAG http://www.ebi.ac.uk/pdbe-srv/view/entry/2UAG PDB 2UUO http://www.ebi.ac.uk/pdbe-srv/view/entry/2UUO PDB 2UUP http://www.ebi.ac.uk/pdbe-srv/view/entry/2UUP PDB 2VTD http://www.ebi.ac.uk/pdbe-srv/view/entry/2VTD PDB 2VTE http://www.ebi.ac.uk/pdbe-srv/view/entry/2VTE PDB 2WJP http://www.ebi.ac.uk/pdbe-srv/view/entry/2WJP PDB 2X5O http://www.ebi.ac.uk/pdbe-srv/view/entry/2X5O PDB 2XPC http://www.ebi.ac.uk/pdbe-srv/view/entry/2XPC PDB 2Y1O http://www.ebi.ac.uk/pdbe-srv/view/entry/2Y1O PDB 2Y66 http://www.ebi.ac.uk/pdbe-srv/view/entry/2Y66 PDB 2Y67 http://www.ebi.ac.uk/pdbe-srv/view/entry/2Y67 PDB 2Y68 http://www.ebi.ac.uk/pdbe-srv/view/entry/2Y68 PDB 3UAG http://www.ebi.ac.uk/pdbe-srv/view/entry/3UAG PDB 4UAG http://www.ebi.ac.uk/pdbe-srv/view/entry/4UAG PDB 5A5E http://www.ebi.ac.uk/pdbe-srv/view/entry/5A5E PDB 5A5F http://www.ebi.ac.uk/pdbe-srv/view/entry/5A5F PDBsum 1E0D http://www.ebi.ac.uk/pdbsum/1E0D PDBsum 1EEH http://www.ebi.ac.uk/pdbsum/1EEH PDBsum 1UAG http://www.ebi.ac.uk/pdbsum/1UAG PDBsum 2JFF http://www.ebi.ac.uk/pdbsum/2JFF PDBsum 2JFG http://www.ebi.ac.uk/pdbsum/2JFG PDBsum 2JFH http://www.ebi.ac.uk/pdbsum/2JFH PDBsum 2UAG http://www.ebi.ac.uk/pdbsum/2UAG PDBsum 2UUO http://www.ebi.ac.uk/pdbsum/2UUO PDBsum 2UUP http://www.ebi.ac.uk/pdbsum/2UUP PDBsum 2VTD http://www.ebi.ac.uk/pdbsum/2VTD PDBsum 2VTE http://www.ebi.ac.uk/pdbsum/2VTE PDBsum 2WJP http://www.ebi.ac.uk/pdbsum/2WJP PDBsum 2X5O http://www.ebi.ac.uk/pdbsum/2X5O PDBsum 2XPC http://www.ebi.ac.uk/pdbsum/2XPC PDBsum 2Y1O http://www.ebi.ac.uk/pdbsum/2Y1O PDBsum 2Y66 http://www.ebi.ac.uk/pdbsum/2Y66 PDBsum 2Y67 http://www.ebi.ac.uk/pdbsum/2Y67 PDBsum 2Y68 http://www.ebi.ac.uk/pdbsum/2Y68 PDBsum 3UAG http://www.ebi.ac.uk/pdbsum/3UAG PDBsum 4UAG http://www.ebi.ac.uk/pdbsum/4UAG PDBsum 5A5E http://www.ebi.ac.uk/pdbsum/5A5E PDBsum 5A5F http://www.ebi.ac.uk/pdbsum/5A5F PSORT swissprot:MURD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MURD_ECOLI PSORT-B swissprot:MURD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MURD_ECOLI PSORT2 swissprot:MURD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MURD_ECOLI Pfam PF02875 http://pfam.xfam.org/family/PF02875 Pfam PF08245 http://pfam.xfam.org/family/PF08245 Phobius swissprot:MURD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MURD_ECOLI PhylomeDB P14900 http://phylomedb.org/?seqid=P14900 ProteinModelPortal P14900 http://www.proteinmodelportal.org/query/uniprot/P14900 PubMed 10966819 http://www.ncbi.nlm.nih.gov/pubmed/10966819 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1765076 http://www.ncbi.nlm.nih.gov/pubmed/1765076 PubMed 2129548 http://www.ncbi.nlm.nih.gov/pubmed/2129548 PubMed 2179861 http://www.ncbi.nlm.nih.gov/pubmed/2179861 PubMed 2509435 http://www.ncbi.nlm.nih.gov/pubmed/2509435 PubMed 9218784 http://www.ncbi.nlm.nih.gov/pubmed/9218784 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414630 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414630 RefSeq WP_000796481 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000796481 SMR P14900 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P14900 STRING 511145.b0088 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0088&targetmode=cogs STRING COG0771 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0771&targetmode=cogs SUPFAM SSF53244 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53244 SUPFAM SSF53623 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53623 TIGRFAMs TIGR01087 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01087 UniProtKB MURD_ECOLI http://www.uniprot.org/uniprot/MURD_ECOLI UniProtKB-AC P14900 http://www.uniprot.org/uniprot/P14900 charge swissprot:MURD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MURD_ECOLI eggNOG COG0771 http://eggnogapi.embl.de/nog_data/html/tree/COG0771 eggNOG ENOG4105DMZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DMZ epestfind swissprot:MURD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MURD_ECOLI garnier swissprot:MURD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MURD_ECOLI helixturnhelix swissprot:MURD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MURD_ECOLI hmoment swissprot:MURD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MURD_ECOLI iep swissprot:MURD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MURD_ECOLI inforesidue swissprot:MURD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MURD_ECOLI octanol swissprot:MURD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MURD_ECOLI pepcoil swissprot:MURD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MURD_ECOLI pepdigest swissprot:MURD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MURD_ECOLI pepinfo swissprot:MURD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MURD_ECOLI pepnet swissprot:MURD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MURD_ECOLI pepstats swissprot:MURD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MURD_ECOLI pepwheel swissprot:MURD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MURD_ECOLI pepwindow swissprot:MURD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MURD_ECOLI sigcleave swissprot:MURD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MURD_ECOLI ## Database ID URL or Descriptions # BioGrid 4262508 18 # CATALYTIC ACTIVITY ATP + H(2)O + Ni(2+)(Out) = ADP + phosphate + Ni(2+)(In). {ECO:0000255|HAMAP-Rule MF_01712}. # EcoGene EG12079 nikE # FUNCTION NIKE_ECOLI Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system. {ECO 0000255|HAMAP-Rule MF_01712}. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IEA:UniProtKB-HAMAP. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0015413 nickel-transporting ATPase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0016151 nickel cation binding; IEA:InterPro. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # Gene3D 3.40.50.300 -; 1. # IntAct P33594 10 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR014137 Nickel_NikE # InterPro IPR015858 ABC_transpr_NikE # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00440 Nickel transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism NIKE_ECOLI Escherichia coli (strain K12) # PATRIC 32122404 VBIEscCol129921_3579 # PIR C65145 C65145 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # PROSITE PS51248 NIKE # Pfam PF00005 ABC_tran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Nickel import ATP-binding protein NikE {ECO:0000255|HAMAP-Rule MF_01712} # RefSeq NP_417937 NC_000913.3 # RefSeq WP_000173631 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family. {ECO:0000255|HAMAP-Rule MF_01712}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|HAMAP- Rule MF_01712}. # SMART SM00382 AAA # SUBCELLULAR LOCATION NIKE_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01712}; Peripheral membrane protein {ECO 0000255|HAMAP- Rule MF_01712}. # SUBUNIT The complex is composed of two ATP-binding proteins (NikD and NikE), two transmembrane proteins (NikB and NikC) and a solute-binding protein (NikA). {ECO:0000255|HAMAP-Rule MF_01712}. # SUPFAM SSF52540 SSF52540 # TCDB 3.A.1.5 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR02769 nickel_nikE # eggNOG COG1124 LUCA # eggNOG ENOG4105EFJ Bacteria BLAST swissprot:NIKE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NIKE_ECOLI BioCyc ECOL316407:JW3445-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3445-MONOMER BioCyc EcoCyc:NIKE-MONOMER http://biocyc.org/getid?id=EcoCyc:NIKE-MONOMER BioCyc MetaCyc:NIKE-MONOMER http://biocyc.org/getid?id=MetaCyc:NIKE-MONOMER COG COG1124 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1124 DIP DIP-10344N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10344N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1111/j.1365-2958.1993.tb01247.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb01247.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.3.24 {ECO:0000255|HAMAP-Rule:MF_01712} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.24 {ECO:0000255|HAMAP-Rule:MF_01712} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X73143 http://www.ebi.ac.uk/ena/data/view/X73143 ENZYME 3.6.3.24 {ECO:0000255|HAMAP-Rule:MF_01712} http://enzyme.expasy.org/EC/3.6.3.24 {ECO:0000255|HAMAP-Rule:MF_01712} EchoBASE EB2004 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2004 EcoGene EG12079 http://www.ecogene.org/geneInfo.php?eg_id=EG12079 EnsemblBacteria AAC76505 http://www.ensemblgenomes.org/id/AAC76505 EnsemblBacteria AAC76505 http://www.ensemblgenomes.org/id/AAC76505 EnsemblBacteria BAE77813 http://www.ensemblgenomes.org/id/BAE77813 EnsemblBacteria BAE77813 http://www.ensemblgenomes.org/id/BAE77813 EnsemblBacteria BAE77813 http://www.ensemblgenomes.org/id/BAE77813 EnsemblBacteria b3480 http://www.ensemblgenomes.org/id/b3480 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0015413 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015413 GO_function GO:0016151 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016151 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947987 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947987 InParanoid P33594 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33594 IntAct P33594 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33594* IntEnz 3.6.3.24 {ECO:0000255|HAMAP-Rule:MF_01712} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.24 {ECO:0000255|HAMAP-Rule:MF_01712} InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR014137 http://www.ebi.ac.uk/interpro/entry/IPR014137 InterPro IPR015858 http://www.ebi.ac.uk/interpro/entry/IPR015858 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3445 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3445 KEGG_Gene eco:b3480 http://www.genome.jp/dbget-bin/www_bget?eco:b3480 KEGG_Orthology KO:K10824 http://www.genome.jp/dbget-bin/www_bget?KO:K10824 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 MINT MINT-1220565 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1220565 OMA ERIAACH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ERIAACH PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PROSITE PS51248 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51248 PSORT swissprot:NIKE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NIKE_ECOLI PSORT-B swissprot:NIKE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NIKE_ECOLI PSORT2 swissprot:NIKE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NIKE_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Phobius swissprot:NIKE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NIKE_ECOLI PhylomeDB P33594 http://phylomedb.org/?seqid=P33594 ProteinModelPortal P33594 http://www.proteinmodelportal.org/query/uniprot/P33594 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7934931 http://www.ncbi.nlm.nih.gov/pubmed/7934931 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417937 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417937 RefSeq WP_000173631 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000173631 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P33594 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33594 STRING 511145.b3480 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3480&targetmode=cogs STRING COG1124 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1124&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.5 http://www.tcdb.org/search/result.php?tc=3.A.1.5 TIGRFAMs TIGR02769 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02769 UniProtKB NIKE_ECOLI http://www.uniprot.org/uniprot/NIKE_ECOLI UniProtKB-AC P33594 http://www.uniprot.org/uniprot/P33594 charge swissprot:NIKE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NIKE_ECOLI eggNOG COG1124 http://eggnogapi.embl.de/nog_data/html/tree/COG1124 eggNOG ENOG4105EFJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EFJ epestfind swissprot:NIKE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NIKE_ECOLI garnier swissprot:NIKE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NIKE_ECOLI helixturnhelix swissprot:NIKE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NIKE_ECOLI hmoment swissprot:NIKE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NIKE_ECOLI iep swissprot:NIKE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NIKE_ECOLI inforesidue swissprot:NIKE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NIKE_ECOLI octanol swissprot:NIKE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NIKE_ECOLI pepcoil swissprot:NIKE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NIKE_ECOLI pepdigest swissprot:NIKE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NIKE_ECOLI pepinfo swissprot:NIKE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NIKE_ECOLI pepnet swissprot:NIKE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NIKE_ECOLI pepstats swissprot:NIKE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NIKE_ECOLI pepwheel swissprot:NIKE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NIKE_ECOLI pepwindow swissprot:NIKE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NIKE_ECOLI sigcleave swissprot:NIKE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NIKE_ECOLI ## Database ID URL or Descriptions # CAUTION Could be the product of a pseudogene. Compared to E.coli W3110, strain MG1655 has an apparent deletion of about 6 kb which truncates this putative ArsC homolog. {ECO 0000305}. # EcoGene EG13207 yfjU # GO_function GO:0016491 oxidoreductase activity; IEA:UniProtKB-KW. # GO_process GO:0046685 response to arsenic-containing substance; IEA:UniProtKB-KW. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0008150 biological_process # Gene3D 3.40.30.10 -; 1. # InterPro IPR006660 Arsenate_reductase-like # InterPro IPR012336 Thioredoxin-like_fold # Organism YFJU_ECOLI Escherichia coli (strain K12) # PROSITE PS51353 ARSC # Proteomes UP000000625 Chromosome # RecName YFJU_ECOLI Putative arsenate reductase-like protein # SIMILARITY Belongs to the ArsC family. {ECO 0000305}. # SUPFAM SSF52833 SSF52833 # eggNOG COG1393 LUCA BLAST swissprot:YFJU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFJU_ECOLI DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2999 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2999 EcoGene EG13207 http://www.ecogene.org/geneInfo.php?eg_id=EG13207 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_process GO:0046685 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046685 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.30.10 http://www.cathdb.info/version/latest/superfamily/3.40.30.10 InterPro IPR006660 http://www.ebi.ac.uk/interpro/entry/IPR006660 InterPro IPR012336 http://www.ebi.ac.uk/interpro/entry/IPR012336 PROSITE PS51353 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51353 PSORT swissprot:YFJU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFJU_ECOLI PSORT-B swissprot:YFJU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFJU_ECOLI PSORT2 swissprot:YFJU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFJU_ECOLI Phobius swissprot:YFJU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFJU_ECOLI PhylomeDB P0CF86 http://phylomedb.org/?seqid=P0CF86 ProteinModelPortal P0CF86 http://www.proteinmodelportal.org/query/uniprot/P0CF86 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SMR P0CF86 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0CF86 STRING 316407.85675501 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85675501&targetmode=cogs SUPFAM SSF52833 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52833 UniProtKB YFJU_ECOLI http://www.uniprot.org/uniprot/YFJU_ECOLI UniProtKB-AC P0CF86 http://www.uniprot.org/uniprot/P0CF86 charge swissprot:YFJU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFJU_ECOLI eggNOG COG1393 http://eggnogapi.embl.de/nog_data/html/tree/COG1393 epestfind swissprot:YFJU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFJU_ECOLI garnier swissprot:YFJU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFJU_ECOLI helixturnhelix swissprot:YFJU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFJU_ECOLI hmoment swissprot:YFJU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFJU_ECOLI iep swissprot:YFJU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFJU_ECOLI inforesidue swissprot:YFJU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFJU_ECOLI octanol swissprot:YFJU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFJU_ECOLI pepcoil swissprot:YFJU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFJU_ECOLI pepdigest swissprot:YFJU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFJU_ECOLI pepinfo swissprot:YFJU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFJU_ECOLI pepnet swissprot:YFJU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFJU_ECOLI pepstats swissprot:YFJU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFJU_ECOLI pepwheel swissprot:YFJU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFJU_ECOLI pepwindow swissprot:YFJU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFJU_ECOLI sigcleave swissprot:YFJU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFJU_ECOLI ## Database ID URL or Descriptions # BioGrid 4262941 9 # EcoGene EG11514 gltF # FUNCTION GLTF_ECOLI Involved in induction of the so-called NTR enzymes in response to nitrogen deprivation, as well as in glutamate biosynthesis. May mediate the glutamate-dependent repression of the GLT operon. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # INDUCTION Repressed by H-NS, induced by LeuO. A monocistronic operon. {ECO:0000269|PubMed 19429622}. # IntAct P28721 3 # InterPro IPR010546 DUF1120 # Organism GLTF_ECOLI Escherichia coli (strain K12) # PATRIC 32121850 VBIEscCol129921_3309 # PIR S25281 S25281 # Pfam PF06551 DUF1120 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLTF_ECOLI Protein GltF # RefSeq NP_417681 NC_000913.3 # RefSeq WP_000465371 NZ_LN832404.1 # SIMILARITY To E.coli YhcF. {ECO 0000305}. # SUBCELLULAR LOCATION GLTF_ECOLI Cell membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. # eggNOG ENOG4106AJS Bacteria # eggNOG ENOG410Y11X LUCA BLAST swissprot:GLTF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLTF_ECOLI BioCyc ECOL316407:JW3181-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3181-MONOMER BioCyc EcoCyc:EG11514-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11514-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1992.tb01450.x http://dx.doi.org/10.1111/j.1365-2958.1992.tb01450.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00108-09 http://dx.doi.org/10.1128/JB.00108-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M74162 http://www.ebi.ac.uk/ena/data/view/M74162 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB1476 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1476 EcoGene EG11514 http://www.ecogene.org/geneInfo.php?eg_id=EG11514 EnsemblBacteria AAC76246 http://www.ensemblgenomes.org/id/AAC76246 EnsemblBacteria AAC76246 http://www.ensemblgenomes.org/id/AAC76246 EnsemblBacteria BAE77258 http://www.ensemblgenomes.org/id/BAE77258 EnsemblBacteria BAE77258 http://www.ensemblgenomes.org/id/BAE77258 EnsemblBacteria BAE77258 http://www.ensemblgenomes.org/id/BAE77258 EnsemblBacteria b3214 http://www.ensemblgenomes.org/id/b3214 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 947746 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947746 InParanoid P28721 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P28721 IntAct P28721 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P28721* InterPro IPR010546 http://www.ebi.ac.uk/interpro/entry/IPR010546 KEGG_Gene ecj:JW3181 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3181 KEGG_Gene eco:b3214 http://www.genome.jp/dbget-bin/www_bget?eco:b3214 OMA TINCSAP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TINCSAP PSORT swissprot:GLTF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLTF_ECOLI PSORT-B swissprot:GLTF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLTF_ECOLI PSORT2 swissprot:GLTF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLTF_ECOLI Pfam PF06551 http://pfam.xfam.org/family/PF06551 Phobius swissprot:GLTF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLTF_ECOLI ProteinModelPortal P28721 http://www.proteinmodelportal.org/query/uniprot/P28721 PubMed 1447980 http://www.ncbi.nlm.nih.gov/pubmed/1447980 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19429622 http://www.ncbi.nlm.nih.gov/pubmed/19429622 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417681 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417681 RefSeq WP_000465371 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000465371 STRING 511145.b3214 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3214&targetmode=cogs UniProtKB GLTF_ECOLI http://www.uniprot.org/uniprot/GLTF_ECOLI UniProtKB-AC P28721 http://www.uniprot.org/uniprot/P28721 charge swissprot:GLTF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLTF_ECOLI eggNOG ENOG4106AJS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106AJS eggNOG ENOG410Y11X http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y11X epestfind swissprot:GLTF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLTF_ECOLI garnier swissprot:GLTF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLTF_ECOLI helixturnhelix swissprot:GLTF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLTF_ECOLI hmoment swissprot:GLTF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLTF_ECOLI iep swissprot:GLTF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLTF_ECOLI inforesidue swissprot:GLTF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLTF_ECOLI octanol swissprot:GLTF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLTF_ECOLI pepcoil swissprot:GLTF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLTF_ECOLI pepdigest swissprot:GLTF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLTF_ECOLI pepinfo swissprot:GLTF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLTF_ECOLI pepnet swissprot:GLTF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLTF_ECOLI pepstats swissprot:GLTF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLTF_ECOLI pepwheel swissprot:GLTF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLTF_ECOLI pepwindow swissprot:GLTF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLTF_ECOLI sigcleave swissprot:GLTF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLTF_ECOLI ## Database ID URL or Descriptions # BioGrid 4260544 113 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG12950 yfdM # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_function GO:0009007 site-specific DNA-methyltransferase (adenine-specific) activity; IEA:InterPro. # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0008168 methyltransferase activity # InterPro IPR008593 Dam_MeTrfase # Organism YFDM_ECOLI Escherichia coli (strain K12) # PATRIC 48664114 VBIEscCol107702_2397 # PIR A65009 A65009 # PROSITE PS00092 N6_MTASE # Pfam PF05869 Dam # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # REBASE 20309 M.EcoW3110ORF2350P # RecName YFDM_ECOLI Putative uncharacterized protein YfdM # RefSeq WP_000066913 NZ_LN832404.1 # TIGRFAMs TIGR01712 phage_N6A_met BLAST swissprot:YFDM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFDM_ECOLI BioCyc ECOL316407:JW2352-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2352-MONOMER BioCyc EcoCyc:G7225-MONOMER http://biocyc.org/getid?id=EcoCyc:G7225-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/14.17.7115 http://dx.doi.org/10.1093/nar/14.17.7115 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X04387 http://www.ebi.ac.uk/ena/data/view/X04387 EchoBASE EB2784 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2784 EcoGene EG12950 http://www.ecogene.org/geneInfo.php?eg_id=EG12950 EnsemblBacteria BAE76696 http://www.ensemblgenomes.org/id/BAE76696 EnsemblBacteria BAE76696 http://www.ensemblgenomes.org/id/BAE76696 EnsemblBacteria BAE76696 http://www.ensemblgenomes.org/id/BAE76696 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0009007 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009007 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 IntAct P76509 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76509* InterPro IPR008593 http://www.ebi.ac.uk/interpro/entry/IPR008593 KEGG_Gene ecj:JW2352 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2352 PROSITE PS00092 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00092 PSORT swissprot:YFDM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFDM_ECOLI PSORT-B swissprot:YFDM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFDM_ECOLI PSORT2 swissprot:YFDM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFDM_ECOLI Pfam PF05869 http://pfam.xfam.org/family/PF05869 Phobius swissprot:YFDM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFDM_ECOLI ProteinModelPortal P76509 http://www.proteinmodelportal.org/query/uniprot/P76509 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3532033 http://www.ncbi.nlm.nih.gov/pubmed/3532033 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 REBASE 20309 http://rebase.neb.com/rebase/enz/20309.html RefSeq WP_000066913 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000066913 STRING 316407.85675370 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85675370&targetmode=cogs TIGRFAMs TIGR01712 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01712 UniProtKB YFDM_ECOLI http://www.uniprot.org/uniprot/YFDM_ECOLI UniProtKB-AC P76509 http://www.uniprot.org/uniprot/P76509 charge swissprot:YFDM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFDM_ECOLI epestfind swissprot:YFDM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFDM_ECOLI garnier swissprot:YFDM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFDM_ECOLI helixturnhelix swissprot:YFDM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFDM_ECOLI hmoment swissprot:YFDM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFDM_ECOLI iep swissprot:YFDM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFDM_ECOLI inforesidue swissprot:YFDM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFDM_ECOLI octanol swissprot:YFDM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFDM_ECOLI pepcoil swissprot:YFDM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFDM_ECOLI pepdigest swissprot:YFDM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFDM_ECOLI pepinfo swissprot:YFDM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFDM_ECOLI pepnet swissprot:YFDM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFDM_ECOLI pepstats swissprot:YFDM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFDM_ECOLI pepwheel swissprot:YFDM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFDM_ECOLI pepwindow swissprot:YFDM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFDM_ECOLI sigcleave swissprot:YFDM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFDM_ECOLI ## Database ID URL or Descriptions # BioGrid 4263339 7 # EcoGene EG11462 yigE # InterPro IPR018711 NAGPA # Organism YIGE_ECOLI Escherichia coli (strain K12) # PATRIC 32123129 VBIEscCol129921_3930 # PIR S30742 S30742 # Pfam PF09992 NAGPA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIGE_ECOLI Uncharacterized protein YigE # RefSeq WP_000951133 NZ_LN832404.1 # RefSeq YP_026261 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA67610.1; Type=Frameshift; Positions=127; Note=Produces two separate ORFs.; Evidence={ECO:0000305}; Sequence=AAA67611.1; Type=Frameshift; Positions=127; Note=Produces two separate ORFs.; Evidence={ECO 0000305}; # eggNOG COG3698 LUCA # eggNOG ENOG4108T58 Bacteria BLAST swissprot:YIGE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIGE_ECOLI BioCyc ECOL316407:JW5591-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5591-MONOMER BioCyc EcoCyc:EG11462-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11462-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L02122 http://www.ebi.ac.uk/ena/data/view/L02122 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1430 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1430 EcoGene EG11462 http://www.ecogene.org/geneInfo.php?eg_id=EG11462 EnsemblBacteria AAT48219 http://www.ensemblgenomes.org/id/AAT48219 EnsemblBacteria AAT48219 http://www.ensemblgenomes.org/id/AAT48219 EnsemblBacteria BAE77486 http://www.ensemblgenomes.org/id/BAE77486 EnsemblBacteria BAE77486 http://www.ensemblgenomes.org/id/BAE77486 EnsemblBacteria BAE77486 http://www.ensemblgenomes.org/id/BAE77486 EnsemblBacteria b4482 http://www.ensemblgenomes.org/id/b4482 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 2847679 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2847679 HOGENOM HOG000126503 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126503&db=HOGENOM6 InParanoid P27840 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P27840 InterPro IPR018711 http://www.ebi.ac.uk/interpro/entry/IPR018711 KEGG_Gene ecj:JW5591 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5591 KEGG_Gene eco:b4482 http://www.genome.jp/dbget-bin/www_bget?eco:b4482 OMA MGLYVEN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MGLYVEN PSORT swissprot:YIGE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIGE_ECOLI PSORT-B swissprot:YIGE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIGE_ECOLI PSORT2 swissprot:YIGE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIGE_ECOLI Pfam PF09992 http://pfam.xfam.org/family/PF09992 Phobius swissprot:YIGE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIGE_ECOLI ProteinModelPortal P27840 http://www.proteinmodelportal.org/query/uniprot/P27840 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000951133 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000951133 RefSeq YP_026261 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026261 STRING 511145.b4482 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4482&targetmode=cogs UniProtKB YIGE_ECOLI http://www.uniprot.org/uniprot/YIGE_ECOLI UniProtKB-AC P27840 http://www.uniprot.org/uniprot/P27840 charge swissprot:YIGE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIGE_ECOLI eggNOG COG3698 http://eggnogapi.embl.de/nog_data/html/tree/COG3698 eggNOG ENOG4108T58 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108T58 epestfind swissprot:YIGE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIGE_ECOLI garnier swissprot:YIGE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIGE_ECOLI helixturnhelix swissprot:YIGE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIGE_ECOLI hmoment swissprot:YIGE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIGE_ECOLI iep swissprot:YIGE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIGE_ECOLI inforesidue swissprot:YIGE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIGE_ECOLI octanol swissprot:YIGE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIGE_ECOLI pepcoil swissprot:YIGE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIGE_ECOLI pepdigest swissprot:YIGE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIGE_ECOLI pepinfo swissprot:YIGE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIGE_ECOLI pepnet swissprot:YIGE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIGE_ECOLI pepstats swissprot:YIGE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIGE_ECOLI pepwheel swissprot:YIGE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIGE_ECOLI pepwindow swissprot:YIGE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIGE_ECOLI sigcleave swissprot:YIGE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIGE_ECOLI ## Database ID URL or Descriptions # BioGrid 4259737 6 # DISRUPTION PHENOTYPE Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain. {ECO:0000269|PubMed 20345943}. # EcoGene EG12328 yadN # FUNCTION YADN_ECOLI Part of the yadCKLM-htrE-yadVN fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. {ECO 0000269|PubMed 20345943}. # GO_component GO:0009289 pilus; IEA:UniProtKB-SubCell. # GO_process GO:0007155 cell adhesion; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0007155 cell adhesion # Gene3D 2.60.40.1090 -; 1. # INDUCTION Repressed by H-NS. {ECO:0000269|PubMed 20345943}. # InterPro IPR000259 Adhesion_dom_fimbrial # InterPro IPR008966 Adhesion_dom # MISCELLANEOUS The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed. {ECO:0000305|PubMed 20345943}. # Organism YADN_ECOLI Escherichia coli (strain K12) # PATRIC 32115389 VBIEscCol129921_0146 # PIR E64737 E64737 # Pfam PF00419 Fimbrial # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YADN_ECOLI Uncharacterized fimbrial-like protein YadN # RefSeq NP_414683 NC_000913.3 # RefSeq WP_000038438 NZ_LN832404.1 # SIMILARITY Belongs to the fimbrial protein family. {ECO 0000305}. # SUBCELLULAR LOCATION YADN_ECOLI Fimbrium {ECO 0000305}. # SUPFAM SSF49401 SSF49401 BLAST swissprot:YADN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YADN_ECOLI BioCyc ECOL316407:JW0137-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0137-MONOMER BioCyc EcoCyc:EG12328-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12328-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1111/j.1462-2920.2010.02202.x http://dx.doi.org/10.1111/j.1462-2920.2010.02202.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2232 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2232 EcoGene EG12328 http://www.ecogene.org/geneInfo.php?eg_id=EG12328 EnsemblBacteria AAC73252 http://www.ensemblgenomes.org/id/AAC73252 EnsemblBacteria AAC73252 http://www.ensemblgenomes.org/id/AAC73252 EnsemblBacteria BAB96717 http://www.ensemblgenomes.org/id/BAB96717 EnsemblBacteria BAB96717 http://www.ensemblgenomes.org/id/BAB96717 EnsemblBacteria BAB96717 http://www.ensemblgenomes.org/id/BAB96717 EnsemblBacteria b0141 http://www.ensemblgenomes.org/id/b0141 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009289 GO_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 Gene3D 2.60.40.1090 http://www.cathdb.info/version/latest/superfamily/2.60.40.1090 GeneID 944841 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944841 HOGENOM HOG000260127 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260127&db=HOGENOM6 InterPro IPR000259 http://www.ebi.ac.uk/interpro/entry/IPR000259 InterPro IPR008966 http://www.ebi.ac.uk/interpro/entry/IPR008966 KEGG_Gene ecj:JW0137 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0137 KEGG_Gene eco:b0141 http://www.genome.jp/dbget-bin/www_bget?eco:b0141 OMA INNPGDI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=INNPGDI PSORT swissprot:YADN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YADN_ECOLI PSORT-B swissprot:YADN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YADN_ECOLI PSORT2 swissprot:YADN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YADN_ECOLI Pfam PF00419 http://pfam.xfam.org/family/PF00419 Phobius swissprot:YADN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YADN_ECOLI ProteinModelPortal P37050 http://www.proteinmodelportal.org/query/uniprot/P37050 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20345943 http://www.ncbi.nlm.nih.gov/pubmed/20345943 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414683 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414683 RefSeq WP_000038438 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000038438 STRING 511145.b0141 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0141&targetmode=cogs SUPFAM SSF49401 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49401 UniProtKB YADN_ECOLI http://www.uniprot.org/uniprot/YADN_ECOLI UniProtKB-AC P37050 http://www.uniprot.org/uniprot/P37050 charge swissprot:YADN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YADN_ECOLI epestfind swissprot:YADN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YADN_ECOLI garnier swissprot:YADN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YADN_ECOLI helixturnhelix swissprot:YADN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YADN_ECOLI hmoment swissprot:YADN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YADN_ECOLI iep swissprot:YADN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YADN_ECOLI inforesidue swissprot:YADN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YADN_ECOLI octanol swissprot:YADN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YADN_ECOLI pepcoil swissprot:YADN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YADN_ECOLI pepdigest swissprot:YADN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YADN_ECOLI pepinfo swissprot:YADN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YADN_ECOLI pepnet swissprot:YADN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YADN_ECOLI pepstats swissprot:YADN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YADN_ECOLI pepwheel swissprot:YADN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YADN_ECOLI pepwindow swissprot:YADN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YADN_ECOLI sigcleave swissprot:YADN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YADN_ECOLI ## Database ID URL or Descriptions # EcoGene EG40004 insD5 # FUNCTION INSD5_ECOLI Involved in the transposition of the insertion sequence IS2. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006310 DNA recombination; IEA:UniProtKB-KW. # GO_process GO:0015074 DNA integration; IEA:InterPro. # GO_process GO:0032196 transposition; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 3.30.420.10 -; 1. # InterPro IPR001584 Integrase_cat-core # InterPro IPR012337 RNaseH-like_dom # InterPro IPR025948 HTH-like_dom # Organism INSD5_ECOLI Escherichia coli (strain K12) # PIR A64764 C65092 # PROSITE PS50994 INTEGRASE # Pfam PF00665 rve # Pfam PF13276 HTH_21 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSD5_ECOLI Transposase InsD for insertion element IS2I # RefSeq NP_061399 NC_002483.1 # RefSeq NP_414895 NC_000913.3 # RefSeq NP_415920 NC_000913.3 # RefSeq NP_416500 NC_000913.3 # RefSeq NP_417337 NC_000913.3 # RefSeq NP_417517 NC_000913.3 # RefSeq NP_418693 NC_000913.3 # RefSeq WP_000376502 NZ_LN832404.1 # SIMILARITY Contains 1 integrase catalytic domain. {ECO:0000255|PROSITE-ProRule PRU00457}. # SUPFAM SSF53098 SSF53098 # eggNOG ENOG4108MVM Bacteria # eggNOG ENOG410Z4Y8 LUCA BLAST swissprot:INSD5_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSD5_ECOLI DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB4741 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4741 EcoGene EG40004 http://www.ecogene.org/geneInfo.php?eg_id=EG40004 EnsemblBacteria AAC76081 http://www.ensemblgenomes.org/id/AAC76081 EnsemblBacteria AAC76081 http://www.ensemblgenomes.org/id/AAC76081 EnsemblBacteria BAA16573 http://www.ensemblgenomes.org/id/BAA16573 EnsemblBacteria BAA16573 http://www.ensemblgenomes.org/id/BAA16573 EnsemblBacteria BAA16573 http://www.ensemblgenomes.org/id/BAA16573 EnsemblBacteria b3045 http://www.ensemblgenomes.org/id/b3045 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0015074 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015074 GO_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 3.30.420.10 http://www.cathdb.info/version/latest/superfamily/3.30.420.10 GeneID 1263540 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263540 GeneID 945203 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945203 GeneID 945952 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945952 GeneID 946403 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946403 GeneID 947346 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947346 GeneID 947517 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947517 GeneID 948779 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948779 InParanoid P0CF57 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CF57 InterPro IPR001584 http://www.ebi.ac.uk/interpro/entry/IPR001584 InterPro IPR012337 http://www.ebi.ac.uk/interpro/entry/IPR012337 InterPro IPR025948 http://www.ebi.ac.uk/interpro/entry/IPR025948 KEGG_Gene ecj:JW3013 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3013 KEGG_Gene eco:b0361 http://www.genome.jp/dbget-bin/www_bget?eco:b0361 KEGG_Gene eco:b1402 http://www.genome.jp/dbget-bin/www_bget?eco:b1402 KEGG_Gene eco:b1996 http://www.genome.jp/dbget-bin/www_bget?eco:b1996 KEGG_Gene eco:b2860 http://www.genome.jp/dbget-bin/www_bget?eco:b2860 KEGG_Gene eco:b3045 http://www.genome.jp/dbget-bin/www_bget?eco:b3045 KEGG_Gene eco:b4273 http://www.genome.jp/dbget-bin/www_bget?eco:b4273 PROSITE PS50994 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50994 PSORT swissprot:INSD5_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSD5_ECOLI PSORT-B swissprot:INSD5_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSD5_ECOLI PSORT2 swissprot:INSD5_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSD5_ECOLI Pfam PF00665 http://pfam.xfam.org/family/PF00665 Pfam PF13276 http://pfam.xfam.org/family/PF13276 Phobius swissprot:INSD5_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSD5_ECOLI PhylomeDB P0CF57 http://phylomedb.org/?seqid=P0CF57 ProteinModelPortal P0CF57 http://www.proteinmodelportal.org/query/uniprot/P0CF57 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_061399 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061399 RefSeq NP_414895 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414895 RefSeq NP_415920 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415920 RefSeq NP_416500 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416500 RefSeq NP_417337 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417337 RefSeq NP_417517 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417517 RefSeq NP_418693 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418693 RefSeq WP_000376502 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000376502 SMR P0CF57 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0CF57 STRING 511145.b4273 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4273&targetmode=cogs SUPFAM SSF53098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098 UniProtKB INSD5_ECOLI http://www.uniprot.org/uniprot/INSD5_ECOLI UniProtKB-AC P0CF57 http://www.uniprot.org/uniprot/P0CF57 charge swissprot:INSD5_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSD5_ECOLI eggNOG ENOG4108MVM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MVM eggNOG ENOG410Z4Y8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Z4Y8 epestfind swissprot:INSD5_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSD5_ECOLI garnier swissprot:INSD5_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSD5_ECOLI helixturnhelix swissprot:INSD5_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSD5_ECOLI hmoment swissprot:INSD5_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSD5_ECOLI iep swissprot:INSD5_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSD5_ECOLI inforesidue swissprot:INSD5_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSD5_ECOLI octanol swissprot:INSD5_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSD5_ECOLI pepcoil swissprot:INSD5_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSD5_ECOLI pepdigest swissprot:INSD5_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSD5_ECOLI pepinfo swissprot:INSD5_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSD5_ECOLI pepnet swissprot:INSD5_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSD5_ECOLI pepstats swissprot:INSD5_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSD5_ECOLI pepwheel swissprot:INSD5_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSD5_ECOLI pepwindow swissprot:INSD5_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSD5_ECOLI sigcleave swissprot:INSD5_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSD5_ECOLI ## Database ID URL or Descriptions # AltName CPXP_ECOLI Periplasmic accessory protein CpxP # AltName ORF_o167 {ECO:0000303|PubMed 8346018} # BioGrid 4262646 126 # CDD cd09916 CpxP_like # DISRUPTION PHENOTYPE CPXP_ECOLI Hypersensitive to alkaline pH (greater than pH 8.8) (PubMed 9473036). Increased accumulation and toxicity of overexpressed, misfolded periplasmic proteins (PubMed 16303867). {ECO 0000269|PubMed 16303867, ECO 0000269|PubMed 9473036}. # DOMAIN CPXP_ECOLI A region in the N-terminus (residues 55-61) probably interacts with the periplasmic sensor domain of CpxA to inhibit its kinase activity and is also important for CpxP stability (PubMed 16166523). The homodimer has an elongated cradle shape; a hydrophobic cleft on the convex face may interact with periplasmic protein PapE (PubMed 21239493). {ECO 0000269|PubMed 16166523, ECO 0000269|PubMed 21239493}. # EcoGene EG11872 cpxP # FUNCTION CPXP_ECOLI Acts as an auxiliary protein in the Cpx two-component envelope stress response system, helping modulate the Cpx response systems response to some inducers (PubMed 25207645, PubMed 16303867). Binds the periplasmic domain of sensor histidine kinase CpxA, inhibiting induction of the Cpx envelope stress response in the absence of inducer; overexpression decreases Cpx pathway activity (PubMed 16166523, PubMed 21317318). Some periplasmic stimulii (shown for P pili subunit PapE and probably 0.3 M NaCl) increase CpxP's susceptibility to DegP, leading to CpxP degradation, inducing the Cpx pathway (PubMed 16166523, PubMed 16303867). Aids in combating extracytoplasmic protein- mediated toxicity (PubMed 9473036, PubMed 16303867, PubMed 21239493). Overexpression leads to degradation by DegP of misfolded P pili subunits in the periplasm (tested using PapE) (PubMed 21239493). Inhibits autophosphorylation of CpxA in reconstituted liposomes by 50% but has no effect on phosphatase activity of CpxA (PubMed 17259177, PubMed 21239493). Has mild protein chaperone activity (PubMed 21317898, PubMed 21239493). {ECO 0000269|PubMed 16166523, ECO 0000269|PubMed 16303867, ECO 0000269|PubMed 17259177, ECO 0000269|PubMed 21239493, ECO 0000269|PubMed 21317318, ECO 0000269|PubMed 21317898, ECO 0000269|PubMed 25207645, ECO 0000269|PubMed 9473036}. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0051082 unfolded protein binding; IDA:EcoCyc. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0051082 unfolded protein binding # GOslim_process GO:0008150 biological_process # INDUCTION CPXP_ECOLI Induced by envelope stress such as overexpression of misfolded periplasmic proteins (PubMed 9351822). Induced by alkaine pH (tested up to pH 8.4) (PubMed 9473036, PubMed 16166523). Induction is decreased in a degP deletion (PubMed 16166523). Transcription is stimulated by the Cpx two- component signal transduction pathway; sigma factor E (rpoE) is not involved (PubMed 9351822, PubMed 9473036, PubMed 10972835). Transcription induced by spheroplasting, which removes the periplasm and thus this protein; if the protein is anchored to the outer surface of the inner membrane induction does not occur (PubMed 10972835). Induced in persister cells (PubMed 16768798). {ECO 0000269|PubMed 10972835, ECO 0000269|PubMed 16166523, ECO 0000269|PubMed 16768798, ECO 0000269|PubMed 9351822, ECO 0000269|PubMed 9473036}. # INTERACTION CPXP_ECOLI Self; NbExp=2; IntAct=EBI-6413881, EBI-6413881; # InterPro IPR012899 LTXXQ # Organism CPXP_ECOLI Escherichia coli (strain K12) # PATRIC 32123339 VBIEscCol129921_4030 # PDB 3ITF X-ray; 1.45 A; A/B=21-150 # PDB 3QZC X-ray; 2.85 A; A/B=40-151 # PIRSF PIRSF034445 CpxP_Spy # PTM CPXP_ECOLI Degraded by DegP; some CpxP mutant proteins are more susceptible to the protease than others (PubMed 16166523). Degradation probably occurs when CpxP is associated with some misfolded proteins; overexpression of PapE leads to DegP-mediated degradation of CpxP and PapE, which requires the N-terminus of PapE. Overexpression of NlpE does not induce this degradation however (PubMed 16303867). {ECO 0000269|PubMed 16166523, ECO 0000269|PubMed 16303867}. # Pfam PF07813 LTXXQ # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Periplasmic protein CpxP {ECO:0000303|PubMed 9473036} # RefSeq WP_001223800 NZ_LN832404.1 # RefSeq YP_026277 NC_000913.3 # SEQUENCE CAUTION Sequence=AAB03046.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the CpxP/Spy family. {ECO 0000305}. # SUBCELLULAR LOCATION CPXP_ECOLI Periplasm {ECO 0000269|PubMed 25207645, ECO 0000269|PubMed 9473036}. # SUBUNIT CPXP_ECOLI Homodimer; it might alter shape slightly at pH 8.0 when Cpx is induced (PubMed 21317318, PubMed 21239493). Binds the periplasmic sensor domain of CpxA (PubMed 16166523, PubMed 21317318, PubMed 21239493, PubMed 25207645). Interaction with CpxA is not seen in vivo when cells are grown in 0.3 M NaCl, or if the misfolded P pili protein PapE is overexpressed (PubMed 25207645). {ECO 0000269|PubMed 21239493, ECO 0000269|PubMed 21317318, ECO 0000269|PubMed 25207645, ECO 0000305|PubMed 16166523}. # eggNOG COG3678 LUCA # eggNOG ENOG4105FMW Bacteria BLAST swissprot:CPXP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CPXP_ECOLI BioCyc ECOL316407:JW5558-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5558-MONOMER BioCyc EcoCyc:G7816-MONOMER http://biocyc.org/getid?id=EcoCyc:G7816-MONOMER COG COG3678 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3678 DIP DIP-47937N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47937N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsmb.2016 http://dx.doi.org/10.1038/nsmb.2016 DOI 10.1046/j.1365-2958.2000.02074.x http://dx.doi.org/10.1046/j.1365-2958.2000.02074.x DOI 10.1073/pnas.0508936102 http://dx.doi.org/10.1073/pnas.0508936102 DOI 10.1074/jbc.M110.194092 http://dx.doi.org/10.1074/jbc.M110.194092 DOI 10.1074/jbc.M605785200 http://dx.doi.org/10.1074/jbc.M605785200 DOI 10.1093/emboj/16.21.6394 http://dx.doi.org/10.1093/emboj/16.21.6394 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01296-10 http://dx.doi.org/10.1128/JB.01296-10 DOI 10.1128/JB.187.19.6622-6630.2005 http://dx.doi.org/10.1128/JB.187.19.6622-6630.2005 DOI 10.1186/1471-2180-6-53 http://dx.doi.org/10.1186/1471-2180-6-53 DOI 10.1371/journal.pone.0107383 http://dx.doi.org/10.1371/journal.pone.0107383 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1818 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1818 EcoGene EG11872 http://www.ecogene.org/geneInfo.php?eg_id=EG11872 EnsemblBacteria AAT48235 http://www.ensemblgenomes.org/id/AAT48235 EnsemblBacteria AAT48235 http://www.ensemblgenomes.org/id/AAT48235 EnsemblBacteria BAE77396 http://www.ensemblgenomes.org/id/BAE77396 EnsemblBacteria BAE77396 http://www.ensemblgenomes.org/id/BAE77396 EnsemblBacteria BAE77396 http://www.ensemblgenomes.org/id/BAE77396 EnsemblBacteria b4484 http://www.ensemblgenomes.org/id/b4484 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0051082 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051082 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0051082 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051082 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 2847688 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2847688 HOGENOM HOG000285733 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000285733&db=HOGENOM6 InParanoid P0AE85 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AE85 InterPro IPR012899 http://www.ebi.ac.uk/interpro/entry/IPR012899 KEGG_Gene ecj:JW5558 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5558 KEGG_Gene eco:b4484 http://www.genome.jp/dbget-bin/www_bget?eco:b4484 KEGG_Orthology KO:K06006 http://www.genome.jp/dbget-bin/www_bget?KO:K06006 OMA TTIDEMH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TTIDEMH PDB 3ITF http://www.ebi.ac.uk/pdbe-srv/view/entry/3ITF PDB 3QZC http://www.ebi.ac.uk/pdbe-srv/view/entry/3QZC PDBsum 3ITF http://www.ebi.ac.uk/pdbsum/3ITF PDBsum 3QZC http://www.ebi.ac.uk/pdbsum/3QZC PSORT swissprot:CPXP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CPXP_ECOLI PSORT-B swissprot:CPXP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CPXP_ECOLI PSORT2 swissprot:CPXP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CPXP_ECOLI Pfam PF07813 http://pfam.xfam.org/family/PF07813 Phobius swissprot:CPXP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CPXP_ECOLI ProteinModelPortal P0AE85 http://www.proteinmodelportal.org/query/uniprot/P0AE85 PubMed 10972835 http://www.ncbi.nlm.nih.gov/pubmed/10972835 PubMed 16166523 http://www.ncbi.nlm.nih.gov/pubmed/16166523 PubMed 16303867 http://www.ncbi.nlm.nih.gov/pubmed/16303867 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16768798 http://www.ncbi.nlm.nih.gov/pubmed/16768798 PubMed 17259177 http://www.ncbi.nlm.nih.gov/pubmed/17259177 PubMed 21239493 http://www.ncbi.nlm.nih.gov/pubmed/21239493 PubMed 21317318 http://www.ncbi.nlm.nih.gov/pubmed/21317318 PubMed 21317898 http://www.ncbi.nlm.nih.gov/pubmed/21317898 PubMed 25207645 http://www.ncbi.nlm.nih.gov/pubmed/25207645 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9351822 http://www.ncbi.nlm.nih.gov/pubmed/9351822 PubMed 9473036 http://www.ncbi.nlm.nih.gov/pubmed/9473036 RefSeq WP_001223800 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001223800 RefSeq YP_026277 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026277 SMR P0AE85 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AE85 STRING 511145.b4484 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4484&targetmode=cogs STRING COG3678 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3678&targetmode=cogs UniProtKB CPXP_ECOLI http://www.uniprot.org/uniprot/CPXP_ECOLI UniProtKB-AC P0AE85 http://www.uniprot.org/uniprot/P0AE85 charge swissprot:CPXP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CPXP_ECOLI eggNOG COG3678 http://eggnogapi.embl.de/nog_data/html/tree/COG3678 eggNOG ENOG4105FMW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FMW epestfind swissprot:CPXP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CPXP_ECOLI garnier swissprot:CPXP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CPXP_ECOLI helixturnhelix swissprot:CPXP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CPXP_ECOLI hmoment swissprot:CPXP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CPXP_ECOLI iep swissprot:CPXP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CPXP_ECOLI inforesidue swissprot:CPXP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CPXP_ECOLI octanol swissprot:CPXP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CPXP_ECOLI pepcoil swissprot:CPXP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CPXP_ECOLI pepdigest swissprot:CPXP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CPXP_ECOLI pepinfo swissprot:CPXP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CPXP_ECOLI pepnet swissprot:CPXP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CPXP_ECOLI pepstats swissprot:CPXP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CPXP_ECOLI pepwheel swissprot:CPXP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CPXP_ECOLI pepwindow swissprot:CPXP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CPXP_ECOLI sigcleave swissprot:CPXP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CPXP_ECOLI ## Database ID URL or Descriptions # BioGrid 4259929 5 # BioGrid 4259930 16 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG11777 ybfG # InterPro IPR021239 DUF2625 # Organism YBFG_ECOLI Escherichia coli (strain K12) # PATRIC 48660613 VBIEscCol107702_0689 # PIR A64804 A64804 # PIR B64804 B64804 # Pfam PF10946 DUF2625 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBFG_ECOLI Putative uncharacterized protein YbfG # SEQUENCE CAUTION YBFG_ECOLI Sequence=BAA35338.2; Type=Frameshift; Positions=Several; Evidence={ECO 0000305}; Sequence=BAA35347.2; Type=Frameshift; Positions=Several; Evidence={ECO 0000305}; Sequence=U00096; Type=Frameshift; Positions=Several; Evidence={ECO 0000305}; Sequence=U08369; Type=Frameshift; Positions=Several; Evidence={ECO 0000305}; BLAST swissprot:YBFG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBFG_ECOLI BioCyc ECOL316407:JW5094-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5094-MONOMER BioCyc ECOL316407:JW5095-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5095-MONOMER BioCyc EcoCyc:EG11777-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11777-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U08369 http://www.ebi.ac.uk/ena/data/view/U08369 EchoBASE EB1726 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1726 EcoGene EG11777 http://www.ecogene.org/geneInfo.php?eg_id=EG11777 EnsemblBacteria BAA35338 http://www.ensemblgenomes.org/id/BAA35338 EnsemblBacteria BAA35338 http://www.ensemblgenomes.org/id/BAA35338 EnsemblBacteria BAA35338 http://www.ensemblgenomes.org/id/BAA35338 EnsemblBacteria BAA35347 http://www.ensemblgenomes.org/id/BAA35347 EnsemblBacteria BAA35347 http://www.ensemblgenomes.org/id/BAA35347 EnsemblBacteria BAA35347 http://www.ensemblgenomes.org/id/BAA35347 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv HOGENOM HOG000249581 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000249581&db=HOGENOM6 InParanoid P37003 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37003 IntAct P37003 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37003* InterPro IPR021239 http://www.ebi.ac.uk/interpro/entry/IPR021239 KEGG_Gene ecj:JW5094 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5094 KEGG_Gene ecj:JW5095 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5095 OMA RWDGWRE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RWDGWRE PSORT swissprot:YBFG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBFG_ECOLI PSORT-B swissprot:YBFG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBFG_ECOLI PSORT2 swissprot:YBFG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBFG_ECOLI Pfam PF10946 http://pfam.xfam.org/family/PF10946 Phobius swissprot:YBFG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBFG_ECOLI ProteinModelPortal P37003 http://www.proteinmodelportal.org/query/uniprot/P37003 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8083177 http://www.ncbi.nlm.nih.gov/pubmed/8083177 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 STRING 316407.85674740 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85674740&targetmode=cogs UniProtKB YBFG_ECOLI http://www.uniprot.org/uniprot/YBFG_ECOLI UniProtKB-AC P37003 http://www.uniprot.org/uniprot/P37003 charge swissprot:YBFG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBFG_ECOLI epestfind swissprot:YBFG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBFG_ECOLI garnier swissprot:YBFG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBFG_ECOLI helixturnhelix swissprot:YBFG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBFG_ECOLI hmoment swissprot:YBFG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBFG_ECOLI iep swissprot:YBFG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBFG_ECOLI inforesidue swissprot:YBFG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBFG_ECOLI octanol swissprot:YBFG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBFG_ECOLI pepcoil swissprot:YBFG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBFG_ECOLI pepdigest swissprot:YBFG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBFG_ECOLI pepinfo swissprot:YBFG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBFG_ECOLI pepnet swissprot:YBFG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBFG_ECOLI pepstats swissprot:YBFG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBFG_ECOLI pepwheel swissprot:YBFG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBFG_ECOLI pepwindow swissprot:YBFG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBFG_ECOLI sigcleave swissprot:YBFG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBFG_ECOLI ## Database ID URL or Descriptions # AltName (2S,3S)-2-methylcitrate synthase {ECO:0000305|PubMed 12473114} # AltName Citrate synthase {ECO:0000303|PubMed 8508809} # BIOPHYSICOCHEMICAL PROPERTIES PRPC_ECOLI Kinetic parameters KM=5 uM for oxaloacetate (at pH 8 and 35 degrees Celsius) {ECO 0000269|PubMed 9579066}; KM=17 uM for propionyl-CoA (at pH 7.4) {ECO 0000269|PubMed 9325432}; KM=37 uM for propionyl-CoA (at pH 8 and 35 degrees Celsius) {ECO 0000269|PubMed 9579066}; KM=101 uM for acetyl-CoA (at pH 8 and 35 degrees Celsius) {ECO 0000269|PubMed 9579066}; Vmax=0.11 umol/min/mg enzyme with acetyl-CoA as substrate (at pH 8 and 35 degrees Celsius) {ECO 0000269|PubMed 9579066}; Vmax=0.33 umol/min/mg enzyme with propionyl-CoA as substrate (at pH 8 and 35 degrees Celsius) {ECO 0000269|PubMed 9579066}; pH dependence Optimum pH is 9. {ECO 0000269|PubMed 9325432}; Temperature dependence Optimum temperature is between 45 and 50 degrees Celsius. {ECO 0000269|PubMed 9325432}; # BRENDA 2.3.3 2026 # BioGrid 4259809 8 # CATALYTIC ACTIVITY PRPC_ECOLI Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA. {ECO 0000269|PubMed 9325432, ECO 0000269|PubMed 9579066}. # CATALYTIC ACTIVITY PRPC_ECOLI Propanoyl-CoA + H(2)O + oxaloacetate = (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA. {ECO 0000269|PubMed 9325432, ECO 0000269|PubMed 9579066}. # EcoGene EG11756 prpC # FUNCTION PRPC_ECOLI Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the Claisen condensation of propionyl-CoA and oxaloacetate (OAA) to yield (2S,3S)-2-methylcitrate (2-MC) and CoA. Also catalyzes the condensation of oxaloacetate with acetyl- CoA to yield citrate but with a lower specificity. {ECO 0000269|PubMed 8508809, ECO 0000269|PubMed 9325432, ECO 0000269|PubMed 9579066}. # GO_component GO:0005737 cytoplasm; IEA:InterPro. # GO_function GO:0004108 citrate (Si)-synthase activity; IDA:UniProtKB. # GO_function GO:0050440 2-methylcitrate synthase activity; IDA:UniProtKB. # GO_process GO:0006099 tricarboxylic acid cycle; IEA:UniProtKB-UniPathway. # GO_process GO:0019679 propionate metabolic process, methylcitrate cycle; IDA:UniProtKB. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.230.10 -; 1. # Gene3D 1.10.580.10 -; 1. # INDUCTION PRPC_ECOLI By propionate, but not acetate or glucose. Expression of prpBCDE operon is regulated by PrpR, CRP and a variety of sugars such as arabinose, galactose, glucose mannose and xylose. {ECO 0000269|PubMed 12473114, ECO 0000269|PubMed 15805526, ECO 0000269|PubMed 22579471, ECO 0000269|PubMed 9325432, ECO 0000269|PubMed 9579066}. # IntAct P31660 2 # InterPro IPR002020 Citrate_synthase # InterPro IPR011278 2-MeCitrate/Citrate_synth_II # InterPro IPR016142 Citrate_synth-like_lrg_a-sub # InterPro IPR016143 Citrate_synth-like_sm_a-sub # InterPro IPR019810 Citrate_synthase_AS # InterPro IPR024176 Citrate_synthase_bac-typ # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00640 Propanoate metabolism # Organism PRPC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11739 PTHR11739 # PATHWAY Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2. {ECO 0000305|PubMed:9325432}. # PATHWAY Organic acid metabolism; propanoate degradation. {ECO:0000305|PubMed 9325432}. # PATRIC 32115797 VBIEscCol129921_0340 # PIR E64760 E64760 # PIRSF PIRSF001369 Citrate_synth # PRINTS PR00143 CITRTSNTHASE # PROSITE PS00480 CITRATE_SYNTHASE # Pfam PF00285 Citrate_synt # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 2-methylcitrate synthase {ECO:0000303|PubMed 9579066} # RefSeq NP_414867 NC_000913.3 # RefSeq WP_001285927 NZ_LN832404.1 # SIMILARITY Belongs to the citrate synthase family. {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 9579066}. # SUPFAM SSF48256 SSF48256 # TIGRFAMs TIGR01800 cit_synth_II # UniPathway UPA00223 UER00718 # eggNOG COG0372 LUCA # eggNOG ENOG4105BZN Bacteria BLAST swissprot:PRPC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PRPC_ECOLI BioCyc ECOL316407:JW0324-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0324-MONOMER BioCyc EcoCyc:G6198-MONOMER http://biocyc.org/getid?id=EcoCyc:G6198-MONOMER BioCyc MetaCyc:G6198-MONOMER http://biocyc.org/getid?id=MetaCyc:G6198-MONOMER COG COG0372 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0372 DIP DIP-10579N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10579N DOI 10.1007/s002030050518 http://dx.doi.org/10.1007/s002030050518 DOI 10.1016/j.gene.2012.04.074 http://dx.doi.org/10.1016/j.gene.2012.04.074 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1432-1033.2002.03336.x http://dx.doi.org/10.1046/j.1432-1033.2002.03336.x DOI 10.1099/00221287-144-4-929 http://dx.doi.org/10.1099/00221287-144-4-929 DOI 10.1111/j.1432-1033.1993.tb17898.x http://dx.doi.org/10.1111/j.1432-1033.1993.tb17898.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.187.8.2793-2800.2005 http://dx.doi.org/10.1128/JB.187.8.2793-2800.2005 EC_number EC:2.3.3.16 {ECO:0000269|PubMed:9325432, ECO:0000269|PubMed:9579066} http://www.genome.jp/dbget-bin/www_bget?EC:2.3.3.16 {ECO:0000269|PubMed:9325432, ECO:0000269|PubMed:9579066} EC_number EC:2.3.3.5 {ECO:0000269|PubMed:9325432, ECO:0000269|PubMed:9579066} http://www.genome.jp/dbget-bin/www_bget?EC:2.3.3.5 {ECO:0000269|PubMed:9325432, ECO:0000269|PubMed:9579066} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 ENZYME 2.3.3.16 {ECO:0000269|PubMed:9325432, ECO:0000269|PubMed:9579066} http://enzyme.expasy.org/EC/2.3.3.16 {ECO:0000269|PubMed:9325432, ECO:0000269|PubMed:9579066} ENZYME 2.3.3.5 {ECO:0000269|PubMed:9325432, ECO:0000269|PubMed:9579066} http://enzyme.expasy.org/EC/2.3.3.5 {ECO:0000269|PubMed:9325432, ECO:0000269|PubMed:9579066} EchoBASE EB1706 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1706 EcoGene EG11756 http://www.ecogene.org/geneInfo.php?eg_id=EG11756 EnsemblBacteria AAC73436 http://www.ensemblgenomes.org/id/AAC73436 EnsemblBacteria AAC73436 http://www.ensemblgenomes.org/id/AAC73436 EnsemblBacteria BAE76115 http://www.ensemblgenomes.org/id/BAE76115 EnsemblBacteria BAE76115 http://www.ensemblgenomes.org/id/BAE76115 EnsemblBacteria BAE76115 http://www.ensemblgenomes.org/id/BAE76115 EnsemblBacteria b0333 http://www.ensemblgenomes.org/id/b0333 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004108 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004108 GO_function GO:0050440 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050440 GO_process GO:0006099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006099 GO_process GO:0019679 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019679 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.230.10 http://www.cathdb.info/version/latest/superfamily/1.10.230.10 Gene3D 1.10.580.10 http://www.cathdb.info/version/latest/superfamily/1.10.580.10 GeneID 947528 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947528 HOGENOM HOG000021225 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000021225&db=HOGENOM6 InParanoid P31660 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31660 IntAct P31660 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31660* IntEnz 2.3.3.16 {ECO:0000269|PubMed:9325432, ECO:0000269|PubMed:9579066} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.3.16 {ECO:0000269|PubMed:9325432, ECO:0000269|PubMed:9579066} IntEnz 2.3.3.5 {ECO:0000269|PubMed:9325432, ECO:0000269|PubMed:9579066} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.3.5 {ECO:0000269|PubMed:9325432, ECO:0000269|PubMed:9579066} InterPro IPR002020 http://www.ebi.ac.uk/interpro/entry/IPR002020 InterPro IPR011278 http://www.ebi.ac.uk/interpro/entry/IPR011278 InterPro IPR016142 http://www.ebi.ac.uk/interpro/entry/IPR016142 InterPro IPR016143 http://www.ebi.ac.uk/interpro/entry/IPR016143 InterPro IPR019810 http://www.ebi.ac.uk/interpro/entry/IPR019810 InterPro IPR024176 http://www.ebi.ac.uk/interpro/entry/IPR024176 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0324 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0324 KEGG_Gene eco:b0333 http://www.genome.jp/dbget-bin/www_bget?eco:b0333 KEGG_Orthology KO:K01659 http://www.genome.jp/dbget-bin/www_bget?KO:K01659 KEGG_Pathway ko00640 http://www.genome.jp/kegg-bin/show_pathway?ko00640 KEGG_Reaction rn:R00931 http://www.genome.jp/dbget-bin/www_bget?rn:R00931 OMA VIIKAWS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VIIKAWS PANTHER PTHR11739 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11739 PRINTS PR00143 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00143 PROSITE PS00480 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00480 PSORT swissprot:PRPC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PRPC_ECOLI PSORT-B swissprot:PRPC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PRPC_ECOLI PSORT2 swissprot:PRPC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PRPC_ECOLI Pfam PF00285 http://pfam.xfam.org/family/PF00285 Phobius swissprot:PRPC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PRPC_ECOLI PhylomeDB P31660 http://phylomedb.org/?seqid=P31660 ProteinModelPortal P31660 http://www.proteinmodelportal.org/query/uniprot/P31660 PubMed 12473114 http://www.ncbi.nlm.nih.gov/pubmed/12473114 PubMed 15805526 http://www.ncbi.nlm.nih.gov/pubmed/15805526 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22579471 http://www.ncbi.nlm.nih.gov/pubmed/22579471 PubMed 8508809 http://www.ncbi.nlm.nih.gov/pubmed/8508809 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9325432 http://www.ncbi.nlm.nih.gov/pubmed/9325432 PubMed 9579066 http://www.ncbi.nlm.nih.gov/pubmed/9579066 RefSeq NP_414867 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414867 RefSeq WP_001285927 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001285927 SMR P31660 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31660 STRING 511145.b0333 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0333&targetmode=cogs STRING COG0372 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0372&targetmode=cogs SUPFAM SSF48256 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48256 TIGRFAMs TIGR01800 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01800 UniProtKB PRPC_ECOLI http://www.uniprot.org/uniprot/PRPC_ECOLI UniProtKB-AC P31660 http://www.uniprot.org/uniprot/P31660 charge swissprot:PRPC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PRPC_ECOLI eggNOG COG0372 http://eggnogapi.embl.de/nog_data/html/tree/COG0372 eggNOG ENOG4105BZN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZN epestfind swissprot:PRPC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PRPC_ECOLI garnier swissprot:PRPC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PRPC_ECOLI helixturnhelix swissprot:PRPC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PRPC_ECOLI hmoment swissprot:PRPC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PRPC_ECOLI iep swissprot:PRPC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PRPC_ECOLI inforesidue swissprot:PRPC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PRPC_ECOLI octanol swissprot:PRPC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PRPC_ECOLI pepcoil swissprot:PRPC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PRPC_ECOLI pepdigest swissprot:PRPC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PRPC_ECOLI pepinfo swissprot:PRPC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PRPC_ECOLI pepnet swissprot:PRPC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PRPC_ECOLI pepstats swissprot:PRPC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PRPC_ECOLI pepwheel swissprot:PRPC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PRPC_ECOLI pepwindow swissprot:PRPC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PRPC_ECOLI sigcleave swissprot:PRPC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PRPC_ECOLI ## Database ID URL or Descriptions # BioGrid 4262694 5 # CATALYTIC ACTIVITY ATP + methylphosphonate = alpha-D-ribose 1- methylphosphonate 5-triphosphate + adenine. {ECO:0000269|PubMed 22089136}. # EcoGene EG10717 phnH # FUNCTION PHNH_ECOLI Together with PhnG, PhnI and PhnL is required for the transfer of the ribose triphosphate moiety from ATP to methyl phosphonate. {ECO 0000269|PubMed 22089136}. # GO_component GO:0061694 alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase complex; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IPI:IntAct. # GO_function GO:0061693 alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity; IEA:UniProtKB-EC. # GO_process GO:0019700 organic phosphonate catabolic process; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0009056 catabolic process # INTERACTION PHNH_ECOLI Self; NbExp=5; IntAct=EBI-6401276, EBI-6401276; # IntAct P16686 2 # InterPro IPR008772 Phosphonate_metab_PhnH # MISCELLANEOUS PHNH_ECOLI The sequence shown is that of strains K12 and B. # Organism PHNH_ECOLI Escherichia coli (strain K12) # PATRIC 32123759 VBIEscCol129921_4228 # PDB 2FSU X-ray; 1.70 A; A=1-194 # PDB 4XB6 X-ray; 1.70 A; B/F=1-194 # PIR I35718 I35718 # PIRSF PIRSF020680 PhnH # Pfam PF05845 PhnH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PHNH_ECOLI Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnH # RefSeq NP_418524 NC_000913.3 # RefSeq WP_000171628 NZ_LN832404.1 # SIMILARITY Belongs to the PhnH family. {ECO 0000305}. # SUBUNIT PHNH_ECOLI Homodimer. Forms a complex with PhnG, PhnI, PhnJ and PhnK with the suggested composition PhnG(4)H(2)I(2)J(2)K. {ECO 0000269|PubMed 17993513, ECO 0000269|PubMed 21705661}. # TIGRFAMs TIGR03292 PhnH_redo # eggNOG COG3625 LUCA # eggNOG ENOG4105KZ6 Bacteria BLAST swissprot:PHNH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PHNH_ECOLI BioCyc ECOL316407:JW4061-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4061-MONOMER BioCyc EcoCyc:EG10717-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10717-MONOMER BioCyc MetaCyc:EG10717-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10717-MONOMER COG COG3625 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3625 DIP DIP-10487N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10487N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature10622 http://dx.doi.org/10.1038/nature10622 DOI 10.1073/pnas.1104922108 http://dx.doi.org/10.1073/pnas.1104922108 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01274-07 http://dx.doi.org/10.1128/JB.01274-07 EC_number EC:2.7.8.37 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.8.37 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D90227 http://www.ebi.ac.uk/ena/data/view/D90227 EMBL J05260 http://www.ebi.ac.uk/ena/data/view/J05260 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 2.7.8.37 http://enzyme.expasy.org/EC/2.7.8.37 EchoBASE EB0711 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0711 EcoGene EG10717 http://www.ecogene.org/geneInfo.php?eg_id=EG10717 EnsemblBacteria AAC77061 http://www.ensemblgenomes.org/id/AAC77061 EnsemblBacteria AAC77061 http://www.ensemblgenomes.org/id/AAC77061 EnsemblBacteria BAE78103 http://www.ensemblgenomes.org/id/BAE78103 EnsemblBacteria BAE78103 http://www.ensemblgenomes.org/id/BAE78103 EnsemblBacteria BAE78103 http://www.ensemblgenomes.org/id/BAE78103 EnsemblBacteria b4100 http://www.ensemblgenomes.org/id/b4100 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0061694 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061694 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0061693 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061693 GO_process GO:0019700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019700 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GeneID 948619 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948619 HOGENOM HOG000127018 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000127018&db=HOGENOM6 InParanoid P16686 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P16686 IntAct P16686 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P16686* IntEnz 2.7.8.37 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.8.37 InterPro IPR008772 http://www.ebi.ac.uk/interpro/entry/IPR008772 KEGG_Gene ecj:JW4061 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4061 KEGG_Gene eco:b4100 http://www.genome.jp/dbget-bin/www_bget?eco:b4100 KEGG_Orthology KO:K06165 http://www.genome.jp/dbget-bin/www_bget?KO:K06165 OMA GIADERM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GIADERM PDB 2FSU http://www.ebi.ac.uk/pdbe-srv/view/entry/2FSU PDB 4XB6 http://www.ebi.ac.uk/pdbe-srv/view/entry/4XB6 PDBsum 2FSU http://www.ebi.ac.uk/pdbsum/2FSU PDBsum 4XB6 http://www.ebi.ac.uk/pdbsum/4XB6 PSORT swissprot:PHNH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PHNH_ECOLI PSORT-B swissprot:PHNH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PHNH_ECOLI PSORT2 swissprot:PHNH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PHNH_ECOLI Pfam PF05845 http://pfam.xfam.org/family/PF05845 Phobius swissprot:PHNH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PHNH_ECOLI PhylomeDB P16686 http://phylomedb.org/?seqid=P16686 ProteinModelPortal P16686 http://www.proteinmodelportal.org/query/uniprot/P16686 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17993513 http://www.ncbi.nlm.nih.gov/pubmed/17993513 PubMed 1840580 http://www.ncbi.nlm.nih.gov/pubmed/1840580 PubMed 2155230 http://www.ncbi.nlm.nih.gov/pubmed/2155230 PubMed 21705661 http://www.ncbi.nlm.nih.gov/pubmed/21705661 PubMed 22089136 http://www.ncbi.nlm.nih.gov/pubmed/22089136 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418524 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418524 RefSeq WP_000171628 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000171628 SMR P16686 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P16686 STRING 511145.b4100 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4100&targetmode=cogs STRING COG3625 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3625&targetmode=cogs TIGRFAMs TIGR03292 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03292 UniProtKB PHNH_ECOLI http://www.uniprot.org/uniprot/PHNH_ECOLI UniProtKB-AC P16686 http://www.uniprot.org/uniprot/P16686 charge swissprot:PHNH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PHNH_ECOLI eggNOG COG3625 http://eggnogapi.embl.de/nog_data/html/tree/COG3625 eggNOG ENOG4105KZ6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KZ6 epestfind swissprot:PHNH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PHNH_ECOLI garnier swissprot:PHNH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PHNH_ECOLI helixturnhelix swissprot:PHNH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PHNH_ECOLI hmoment swissprot:PHNH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PHNH_ECOLI iep swissprot:PHNH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PHNH_ECOLI inforesidue swissprot:PHNH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PHNH_ECOLI octanol swissprot:PHNH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PHNH_ECOLI pepcoil swissprot:PHNH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PHNH_ECOLI pepdigest swissprot:PHNH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PHNH_ECOLI pepinfo swissprot:PHNH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PHNH_ECOLI pepnet swissprot:PHNH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PHNH_ECOLI pepstats swissprot:PHNH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PHNH_ECOLI pepwheel swissprot:PHNH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PHNH_ECOLI pepwindow swissprot:PHNH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PHNH_ECOLI sigcleave swissprot:PHNH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PHNH_ECOLI ## Database ID URL or Descriptions # BioGrid 4263212 4 # DISRUPTION PHENOTYPE Deletion of this gene does not affect the ability to synthesize glutathionylspermidine. There is no visible differences between wild-type and mutant strain growth in LB media. {ECO:0000269|PubMed 23097746}. # EcoGene EG11812 yjfC # FUNCTION YJFC_ECOLI May be a ligase forming an amide bond. Shows ATPase activity. Despite its similarity to the C-terminal synthetase domain of Gss, is not a glutathionylspermidine (Gsp) synthetase. Cannot synthesize Gsp, glutathione (GSH), or GSH intermediates, from GSH and spermidine, cysteine and glutamate, gamma- glutamylcysteine and spermidine, and gamma-glutamylcysteine and glycine. Does not bind to Gsp. {ECO 0000269|PubMed 23097746}. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016874 ligase activity; IEA:UniProtKB-KW. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # InterPro IPR005494 GSPS_pre-ATP-grasp-like_dom # InterPro IPR016185 PreATP-grasp_dom # Organism YJFC_ECOLI Escherichia coli (strain K12) # PATRIC 32123947 VBIEscCol129921_4318 # PIR S56411 S56411 # Pfam PF03738 GSP_synth # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJFC_ECOLI Putative acid--amine ligase YjfC # RefSeq NP_418607 NC_000913.3 # RefSeq WP_000943959 NZ_LN832404.1 # SIMILARITY Belongs to the glutathionylspermidine synthase preATP- grasp family. {ECO 0000305}. # SUPFAM SSF52440 SSF52440 # eggNOG COG0754 LUCA # eggNOG ENOG4106032 Bacteria BLAST swissprot:YJFC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJFC_ECOLI BioCyc ECOL316407:JW4144-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4144-MONOMER BioCyc EcoCyc:EG11812-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11812-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.3.1.- http://www.genome.jp/dbget-bin/www_bget?EC:6.3.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L20915 http://www.ebi.ac.uk/ena/data/view/L20915 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 6.3.1.- http://enzyme.expasy.org/EC/6.3.1.- EchoBASE EB1760 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1760 EcoGene EG11812 http://www.ecogene.org/geneInfo.php?eg_id=EG11812 EnsemblBacteria AAC77143 http://www.ensemblgenomes.org/id/AAC77143 EnsemblBacteria AAC77143 http://www.ensemblgenomes.org/id/AAC77143 EnsemblBacteria BAE78187 http://www.ensemblgenomes.org/id/BAE78187 EnsemblBacteria BAE78187 http://www.ensemblgenomes.org/id/BAE78187 EnsemblBacteria BAE78187 http://www.ensemblgenomes.org/id/BAE78187 EnsemblBacteria b4186 http://www.ensemblgenomes.org/id/b4186 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GeneID 948699 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948699 HOGENOM HOG000249104 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000249104&db=HOGENOM6 InParanoid P33222 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33222 IntEnz 6.3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.1 InterPro IPR005494 http://www.ebi.ac.uk/interpro/entry/IPR005494 InterPro IPR016185 http://www.ebi.ac.uk/interpro/entry/IPR016185 KEGG_Gene ecj:JW4144 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4144 KEGG_Gene eco:b4186 http://www.genome.jp/dbget-bin/www_bget?eco:b4186 OMA MCLEVVE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MCLEVVE PSORT swissprot:YJFC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJFC_ECOLI PSORT-B swissprot:YJFC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJFC_ECOLI PSORT2 swissprot:YJFC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJFC_ECOLI Pfam PF03738 http://pfam.xfam.org/family/PF03738 Phobius swissprot:YJFC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJFC_ECOLI PhylomeDB P33222 http://phylomedb.org/?seqid=P33222 ProteinModelPortal P33222 http://www.proteinmodelportal.org/query/uniprot/P33222 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 23097746 http://www.ncbi.nlm.nih.gov/pubmed/23097746 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 7961409 http://www.ncbi.nlm.nih.gov/pubmed/7961409 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418607 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418607 RefSeq WP_000943959 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000943959 SMR P33222 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33222 STRING 511145.b4186 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4186&targetmode=cogs SUPFAM SSF52440 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52440 UniProtKB YJFC_ECOLI http://www.uniprot.org/uniprot/YJFC_ECOLI UniProtKB-AC P33222 http://www.uniprot.org/uniprot/P33222 charge swissprot:YJFC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJFC_ECOLI eggNOG COG0754 http://eggnogapi.embl.de/nog_data/html/tree/COG0754 eggNOG ENOG4106032 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106032 epestfind swissprot:YJFC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJFC_ECOLI garnier swissprot:YJFC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJFC_ECOLI helixturnhelix swissprot:YJFC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJFC_ECOLI hmoment swissprot:YJFC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJFC_ECOLI iep swissprot:YJFC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJFC_ECOLI inforesidue swissprot:YJFC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJFC_ECOLI octanol swissprot:YJFC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJFC_ECOLI pepcoil swissprot:YJFC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJFC_ECOLI pepdigest swissprot:YJFC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJFC_ECOLI pepinfo swissprot:YJFC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJFC_ECOLI pepnet swissprot:YJFC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJFC_ECOLI pepstats swissprot:YJFC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJFC_ECOLI pepwheel swissprot:YJFC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJFC_ECOLI pepwindow swissprot:YJFC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJFC_ECOLI sigcleave swissprot:YJFC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJFC_ECOLI ## Database ID URL or Descriptions # AltName PSS_ECOLI Phosphatidylserine synthase # BRENDA 2.7.8 2026 # BioGrid 4259429 210 # CATALYTIC ACTIVITY PSS_ECOLI CDP-diacylglycerol + L-serine = CMP + (3-sn- phosphatidyl)-L-serine. # EcoGene EG10781 pssA # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_function GO:0003882 CDP-diacylglycerol-serine O-phosphatidyltransferase activity; IDA:EcoCyc. # GO_process GO:0008654 phospholipid biosynthetic process; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # IntAct P23830 35 # InterPro IPR001736 PLipase_D/transphosphatidylase # InterPro IPR016270 PLipase-D_PtdSer-synthase-type # InterPro IPR025202 PLD-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00260 Glycine, serine and threonine metabolism # KEGG_Pathway ko00564 Glycerophospholipid metabolism # Organism PSS_ECOLI Escherichia coli (strain K12) # PANTHER PTHR12586 PTHR12586 # PATRIC 32120571 VBIEscCol129921_2688 # PIRSF PIRSF000850 Phospholipase_D_PSS # PROSITE PS50035 PLD; 2 # Pfam PF13091 PLDc_2; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PSS_ECOLI CDP-diacylglycerol--serine O-phosphatidyltransferase # RefSeq NP_417080 NC_000913.3 # RefSeq WP_000949265 NZ_LN832404.1 # SIMILARITY Belongs to the CDP-alcohol phosphatidyltransferase class-II family. {ECO 0000305}. # SIMILARITY Contains 2 PLD phosphodiesterase domains. {ECO:0000255|PROSITE-ProRule PRU00153}. # SMART SM00155 PLDc; 2 # SUBCELLULAR LOCATION PSS_ECOLI Cytoplasm. Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. # SUBUNIT Multimeric. Interacts with ACP, YbgC and PlsB, forming altogether a complex at the inner membrane. {ECO:0000269|PubMed 16294310}. # eggNOG COG1502 LUCA # eggNOG ENOG4105JIM Bacteria BLAST swissprot:PSS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PSS_ECOLI BioCyc ECOL316407:JW2569-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2569-MONOMER BioCyc EcoCyc:PHOSPHASERSYN-MONOMER http://biocyc.org/getid?id=EcoCyc:PHOSPHASERSYN-MONOMER BioCyc MetaCyc:PHOSPHASERSYN-MONOMER http://biocyc.org/getid?id=MetaCyc:PHOSPHASERSYN-MONOMER COG COG1502 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1502 DIP DIP-10593N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10593N DOI 10.1002/pmic.200500115 http://dx.doi.org/10.1002/pmic.200500115 DOI 10.1016/0076-6879(92)09036-3 http://dx.doi.org/10.1016/0076-6879(92)09036-3 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.8.8 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.8.8 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M58699 http://www.ebi.ac.uk/ena/data/view/M58699 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.8.8 http://enzyme.expasy.org/EC/2.7.8.8 EchoBASE EB0774 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0774 EcoGene EG10781 http://www.ecogene.org/geneInfo.php?eg_id=EG10781 EnsemblBacteria AAC75638 http://www.ensemblgenomes.org/id/AAC75638 EnsemblBacteria AAC75638 http://www.ensemblgenomes.org/id/AAC75638 EnsemblBacteria BAA16470 http://www.ensemblgenomes.org/id/BAA16470 EnsemblBacteria BAA16470 http://www.ensemblgenomes.org/id/BAA16470 EnsemblBacteria BAA16470 http://www.ensemblgenomes.org/id/BAA16470 EnsemblBacteria b2585 http://www.ensemblgenomes.org/id/b2585 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0003882 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003882 GO_process GO:0008654 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008654 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 947059 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947059 HOGENOM HOG000270167 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000270167&db=HOGENOM6 InParanoid P23830 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23830 IntAct P23830 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P23830* IntEnz 2.7.8.8 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.8.8 InterPro IPR001736 http://www.ebi.ac.uk/interpro/entry/IPR001736 InterPro IPR016270 http://www.ebi.ac.uk/interpro/entry/IPR016270 InterPro IPR025202 http://www.ebi.ac.uk/interpro/entry/IPR025202 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2569 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2569 KEGG_Gene eco:b2585 http://www.genome.jp/dbget-bin/www_bget?eco:b2585 KEGG_Orthology KO:K00998 http://www.genome.jp/dbget-bin/www_bget?KO:K00998 KEGG_Pathway ko00260 http://www.genome.jp/kegg-bin/show_pathway?ko00260 KEGG_Pathway ko00564 http://www.genome.jp/kegg-bin/show_pathway?ko00564 KEGG_Reaction rn:R01800 http://www.genome.jp/dbget-bin/www_bget?rn:R01800 MINT MINT-1218158 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1218158 OMA HLKGFVI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HLKGFVI PANTHER PTHR12586 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12586 PROSITE PS50035 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50035 PSORT swissprot:PSS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PSS_ECOLI PSORT-B swissprot:PSS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PSS_ECOLI PSORT2 swissprot:PSS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PSS_ECOLI Pfam PF13091 http://pfam.xfam.org/family/PF13091 Phobius swissprot:PSS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PSS_ECOLI PhylomeDB P23830 http://phylomedb.org/?seqid=P23830 ProteinModelPortal P23830 http://www.proteinmodelportal.org/query/uniprot/P23830 PubMed 1323044 http://www.ncbi.nlm.nih.gov/pubmed/1323044 PubMed 16294310 http://www.ncbi.nlm.nih.gov/pubmed/16294310 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2002065 http://www.ncbi.nlm.nih.gov/pubmed/2002065 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417080 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417080 RefSeq WP_000949265 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000949265 SMART SM00155 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00155 SMR P23830 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P23830 STRING 511145.b2585 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2585&targetmode=cogs STRING COG1502 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1502&targetmode=cogs UniProtKB PSS_ECOLI http://www.uniprot.org/uniprot/PSS_ECOLI UniProtKB-AC P23830 http://www.uniprot.org/uniprot/P23830 charge swissprot:PSS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PSS_ECOLI eggNOG COG1502 http://eggnogapi.embl.de/nog_data/html/tree/COG1502 eggNOG ENOG4105JIM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105JIM epestfind swissprot:PSS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PSS_ECOLI garnier swissprot:PSS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PSS_ECOLI helixturnhelix swissprot:PSS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PSS_ECOLI hmoment swissprot:PSS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PSS_ECOLI iep swissprot:PSS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PSS_ECOLI inforesidue swissprot:PSS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PSS_ECOLI octanol swissprot:PSS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PSS_ECOLI pepcoil swissprot:PSS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PSS_ECOLI pepdigest swissprot:PSS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PSS_ECOLI pepinfo swissprot:PSS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PSS_ECOLI pepnet swissprot:PSS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PSS_ECOLI pepstats swissprot:PSS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PSS_ECOLI pepwheel swissprot:PSS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PSS_ECOLI pepwindow swissprot:PSS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PSS_ECOLI sigcleave swissprot:PSS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PSS_ECOLI ## Database ID URL or Descriptions # AltName PIMT_ECOLI L-isoaspartyl protein carboxyl methyltransferase # AltName PIMT_ECOLI Protein L-isoaspartyl methyltransferase # AltName PIMT_ECOLI Protein-beta-aspartate methyltransferase # BRENDA 2.1.1.77 2026 # BioGrid 4263145 10 # CATALYTIC ACTIVITY PIMT_ECOLI S-adenosyl-L-methionine + protein L- isoaspartate = S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester. # EcoGene EG10689 pcm # FUNCTION PIMT_ECOLI Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. This enzyme does not act on D-aspartyl residues. # GO_component GO:0005737 cytoplasm; IDA:EcoCyc. # GO_function GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity; IDA:EcoCyc. # GO_process GO:0030091 protein repair; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.150 -; 1. # HAMAP MF_00090 PIMT # IntAct P0A7A5 2 # InterPro IPR000682 PCMT # InterPro IPR029063 SAM-dependent_MTases # KEGG_Brite ko01000 Enzymes # Organism PIMT_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11579 PTHR11579 # PATRIC 32120892 VBIEscCol129921_2838 # PDB 3LBF X-ray; 1.80 A; A/B/C/D=1-208 # PIR JH0242 JH0242 # PROSITE PS01279 PCMT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PIMT_ECOLI Protein-L-isoaspartate O-methyltransferase # RefSeq NP_417223 NC_000913.3 # RefSeq WP_000254708 NZ_LN832404.1 # SIMILARITY Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family. {ECO 0000305}. # SUBCELLULAR LOCATION PIMT_ECOLI Cytoplasm. # SUBUNIT PIMT_ECOLI Monomer. # SUPFAM SSF53335 SSF53335 # TIGRFAMs TIGR00080 pimt # eggNOG COG2518 LUCA # eggNOG ENOG4105E26 Bacteria BLAST swissprot:PIMT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PIMT_ECOLI BioCyc ECOL316407:JW2713-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2713-MONOMER BioCyc EcoCyc:EG10689-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10689-MONOMER BioCyc MetaCyc:EG10689-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10689-MONOMER COG COG2518 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2518 DOI 10.1007/BF00284200 http://dx.doi.org/10.1007/BF00284200 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.1.77 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.77 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D17549 http://www.ebi.ac.uk/ena/data/view/D17549 EMBL L07869 http://www.ebi.ac.uk/ena/data/view/L07869 EMBL L07942 http://www.ebi.ac.uk/ena/data/view/L07942 EMBL M63493 http://www.ebi.ac.uk/ena/data/view/M63493 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 ENZYME 2.1.1.77 http://enzyme.expasy.org/EC/2.1.1.77 EchoBASE EB0683 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0683 EcoGene EG10689 http://www.ecogene.org/geneInfo.php?eg_id=EG10689 EnsemblBacteria AAC75785 http://www.ensemblgenomes.org/id/AAC75785 EnsemblBacteria AAC75785 http://www.ensemblgenomes.org/id/AAC75785 EnsemblBacteria BAE76820 http://www.ensemblgenomes.org/id/BAE76820 EnsemblBacteria BAE76820 http://www.ensemblgenomes.org/id/BAE76820 EnsemblBacteria BAE76820 http://www.ensemblgenomes.org/id/BAE76820 EnsemblBacteria b2743 http://www.ensemblgenomes.org/id/b2743 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004719 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004719 GO_process GO:0030091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030091 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 GeneID 944923 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944923 HAMAP MF_00090 http://hamap.expasy.org/unirule/MF_00090 HOGENOM HOG000257189 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000257189&db=HOGENOM6 InParanoid P0A7A5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7A5 IntAct P0A7A5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7A5* IntEnz 2.1.1.77 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.77 InterPro IPR000682 http://www.ebi.ac.uk/interpro/entry/IPR000682 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2713 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2713 KEGG_Gene eco:b2743 http://www.genome.jp/dbget-bin/www_bget?eco:b2743 KEGG_Orthology KO:K00573 http://www.genome.jp/dbget-bin/www_bget?KO:K00573 OMA PYTVAFQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PYTVAFQ PANTHER PTHR11579 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11579 PDB 3LBF http://www.ebi.ac.uk/pdbe-srv/view/entry/3LBF PDBsum 3LBF http://www.ebi.ac.uk/pdbsum/3LBF PROSITE PS01279 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01279 PSORT swissprot:PIMT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PIMT_ECOLI PSORT-B swissprot:PIMT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PIMT_ECOLI PSORT2 swissprot:PIMT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PIMT_ECOLI Phobius swissprot:PIMT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PIMT_ECOLI PhylomeDB P0A7A5 http://phylomedb.org/?seqid=P0A7A5 ProteinModelPortal P0A7A5 http://www.proteinmodelportal.org/query/uniprot/P0A7A5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1860862 http://www.ncbi.nlm.nih.gov/pubmed/1860862 PubMed 7928962 http://www.ncbi.nlm.nih.gov/pubmed/7928962 PubMed 8132457 http://www.ncbi.nlm.nih.gov/pubmed/8132457 PubMed 8208244 http://www.ncbi.nlm.nih.gov/pubmed/8208244 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417223 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417223 RefSeq WP_000254708 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000254708 SMR P0A7A5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7A5 STRING 511145.b2743 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2743&targetmode=cogs STRING COG2518 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2518&targetmode=cogs SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 TIGRFAMs TIGR00080 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00080 UniProtKB PIMT_ECOLI http://www.uniprot.org/uniprot/PIMT_ECOLI UniProtKB-AC P0A7A5 http://www.uniprot.org/uniprot/P0A7A5 charge swissprot:PIMT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PIMT_ECOLI eggNOG COG2518 http://eggnogapi.embl.de/nog_data/html/tree/COG2518 eggNOG ENOG4105E26 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E26 epestfind swissprot:PIMT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PIMT_ECOLI garnier swissprot:PIMT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PIMT_ECOLI helixturnhelix swissprot:PIMT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PIMT_ECOLI hmoment swissprot:PIMT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PIMT_ECOLI iep swissprot:PIMT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PIMT_ECOLI inforesidue swissprot:PIMT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PIMT_ECOLI octanol swissprot:PIMT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PIMT_ECOLI pepcoil swissprot:PIMT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PIMT_ECOLI pepdigest swissprot:PIMT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PIMT_ECOLI pepinfo swissprot:PIMT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PIMT_ECOLI pepnet swissprot:PIMT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PIMT_ECOLI pepstats swissprot:PIMT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PIMT_ECOLI pepwheel swissprot:PIMT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PIMT_ECOLI pepwindow swissprot:PIMT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PIMT_ECOLI sigcleave swissprot:PIMT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PIMT_ECOLI ## Database ID URL or Descriptions # AltName MUKE_ECOLI Protein KicA # BioGrid 4261869 77 # EcoGene EG11252 mukE # FUNCTION MUKE_ECOLI Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF. {ECO 0000269|PubMed 8602138}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-HAMAP. # GO_component GO:0009295 nucleoid; IEA:UniProtKB-SubCell. # GO_process GO:0006260 DNA replication; IEA:UniProtKB-HAMAP. # GO_process GO:0007049 cell cycle; IEA:UniProtKB-KW. # GO_process GO:0007059 chromosome segregation; IEA:UniProtKB-HAMAP. # GO_process GO:0030261 chromosome condensation; IEA:UniProtKB-KW. # GO_process GO:0051301 cell division; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0007049 cell cycle # GOslim_process GO:0007059 chromosome segregation # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0051276 chromosome organization # GOslim_process GO:0051301 cell division # HAMAP MF_01802 MukE # INTERACTION MUKE_ECOLI P60293 mukF; NbExp=4; IntAct=EBI-554672, EBI-554679; # IntAct P22524 11 # InterPro IPR007385 Scp_MukE # KEGG_Brite ko03036 Chromosome # Organism MUKE_ECOLI Escherichia coli (strain K12) # PATRIC 32117059 VBIEscCol129921_0954 # PDB 3EUH X-ray; 2.90 A; C/D/E/F=1-234 # PDB 3RPU X-ray; 3.60 A; D/E/G/H/Y/Z=10-234 # PIR B64832 B64832 # Pfam PF04288 MukE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MUKE_ECOLI Chromosome partition protein MukE # RefSeq NP_415443 NC_000913.3 # RefSeq WP_001295347 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA05458.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA35669.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=CAA40775.1; Type=Frameshift; Positions=105; Evidence={ECO:0000305}; # SIMILARITY Belongs to the MukE family. {ECO 0000305}. # SUBCELLULAR LOCATION MUKE_ECOLI Cytoplasm, nucleoid. Note=Restricted to the nucleoid region. # SUBUNIT Forms a hexameric complex with MukF, (MukF-(MukE)2)2, which forms a ternary complex with MukB. The complex formation is stimulated by calcium or magnesium. {ECO:0000269|PubMed 19135891}. # eggNOG COG3095 LUCA # eggNOG ENOG4105DAH Bacteria BLAST swissprot:MUKE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MUKE_ECOLI BioCyc ECOL316407:JW0906-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0906-MONOMER BioCyc EcoCyc:EG11252-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11252-MONOMER COG COG3095 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3095 DIP DIP-10274N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10274N DOI 10.1007/BF02174381 http://dx.doi.org/10.1007/BF02174381 DOI 10.1016/j.cell.2008.10.050 http://dx.doi.org/10.1016/j.cell.2008.10.050 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.1008678107 http://dx.doi.org/10.1073/pnas.1008678107 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/emboj/18.21.5873 http://dx.doi.org/10.1093/emboj/18.21.5873 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D26440 http://www.ebi.ac.uk/ena/data/view/D26440 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X57550 http://www.ebi.ac.uk/ena/data/view/X57550 EchoBASE EB1232 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1232 EcoGene EG11252 http://www.ecogene.org/geneInfo.php?eg_id=EG11252 EnsemblBacteria AAC74009 http://www.ensemblgenomes.org/id/AAC74009 EnsemblBacteria AAC74009 http://www.ensemblgenomes.org/id/AAC74009 EnsemblBacteria BAA35669 http://www.ensemblgenomes.org/id/BAA35669 EnsemblBacteria BAA35669 http://www.ensemblgenomes.org/id/BAA35669 EnsemblBacteria BAA35669 http://www.ensemblgenomes.org/id/BAA35669 EnsemblBacteria b0923 http://www.ensemblgenomes.org/id/b0923 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0009295 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009295 GO_process GO:0006260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260 GO_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GO_process GO:0007059 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007059 GO_process GO:0030261 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030261 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GOslim_process GO:0007059 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007059 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0051276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051276 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GeneID 945550 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945550 HAMAP MF_01802 http://hamap.expasy.org/unirule/MF_01802 HOGENOM HOG000278254 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278254&db=HOGENOM6 IntAct P22524 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P22524* InterPro IPR007385 http://www.ebi.ac.uk/interpro/entry/IPR007385 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene ecj:JW0906 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0906 KEGG_Gene eco:b0923 http://www.genome.jp/dbget-bin/www_bget?eco:b0923 KEGG_Orthology KO:K03804 http://www.genome.jp/dbget-bin/www_bget?KO:K03804 MINT MINT-1227862 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1227862 PDB 3EUH http://www.ebi.ac.uk/pdbe-srv/view/entry/3EUH PDB 3RPU http://www.ebi.ac.uk/pdbe-srv/view/entry/3RPU PDBsum 3EUH http://www.ebi.ac.uk/pdbsum/3EUH PDBsum 3RPU http://www.ebi.ac.uk/pdbsum/3RPU PSORT swissprot:MUKE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MUKE_ECOLI PSORT-B swissprot:MUKE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MUKE_ECOLI PSORT2 swissprot:MUKE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MUKE_ECOLI Pfam PF04288 http://pfam.xfam.org/family/PF04288 Phobius swissprot:MUKE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MUKE_ECOLI ProteinModelPortal P22524 http://www.proteinmodelportal.org/query/uniprot/P22524 PubMed 10545099 http://www.ncbi.nlm.nih.gov/pubmed/10545099 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19135891 http://www.ncbi.nlm.nih.gov/pubmed/19135891 PubMed 1989883 http://www.ncbi.nlm.nih.gov/pubmed/1989883 PubMed 20921377 http://www.ncbi.nlm.nih.gov/pubmed/20921377 PubMed 7513784 http://www.ncbi.nlm.nih.gov/pubmed/7513784 PubMed 8602138 http://www.ncbi.nlm.nih.gov/pubmed/8602138 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415443 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415443 RefSeq WP_001295347 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295347 SMR P22524 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P22524 STRING 511145.b0923 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0923&targetmode=cogs STRING COG3095 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3095&targetmode=cogs UniProtKB MUKE_ECOLI http://www.uniprot.org/uniprot/MUKE_ECOLI UniProtKB-AC P22524 http://www.uniprot.org/uniprot/P22524 charge swissprot:MUKE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MUKE_ECOLI eggNOG COG3095 http://eggnogapi.embl.de/nog_data/html/tree/COG3095 eggNOG ENOG4105DAH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DAH epestfind swissprot:MUKE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MUKE_ECOLI garnier swissprot:MUKE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MUKE_ECOLI helixturnhelix swissprot:MUKE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MUKE_ECOLI hmoment swissprot:MUKE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MUKE_ECOLI iep swissprot:MUKE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MUKE_ECOLI inforesidue swissprot:MUKE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MUKE_ECOLI octanol swissprot:MUKE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MUKE_ECOLI pepcoil swissprot:MUKE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MUKE_ECOLI pepdigest swissprot:MUKE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MUKE_ECOLI pepinfo swissprot:MUKE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MUKE_ECOLI pepnet swissprot:MUKE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MUKE_ECOLI pepstats swissprot:MUKE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MUKE_ECOLI pepwheel swissprot:MUKE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MUKE_ECOLI pepwindow swissprot:MUKE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MUKE_ECOLI sigcleave swissprot:MUKE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MUKE_ECOLI ## Database ID URL or Descriptions # BioGrid 4259197 5 # EcoGene EG14211 hyfC # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0016491 oxidoreductase activity; IEA:UniProtKB-KW. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0055114 oxidation-reduction process; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # InterPro IPR001694 NADH_UbQ_OxRdtase_su1/FPO # InterPro IPR018086 NADH_UbQ_OxRdtase_su1_CS # KEGG_Brite ko01000 Enzymes # Organism HYFC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11432 PTHR11432 # PATRIC 32120353 VBIEscCol129921_2579 # PIR B65024 B65024 # PROSITE PS00668 COMPLEX1_ND1_2 # Pfam PF00146 NADHdh # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HYFC_ECOLI Hydrogenase-4 component C # RefSeq NP_416978 NC_000913.3 # RefSeq WP_001311024 NZ_LN832404.1 # SIMILARITY Belongs to the complex I subunit 1 family. {ECO 0000305}. # SUBCELLULAR LOCATION HYFC_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 3.D.1.9 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family # eggNOG COG0650 LUCA # eggNOG ENOG4107TDF Bacteria BLAST swissprot:HYFC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HYFC_ECOLI BioCyc ECOL316407:JW2468-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2468-MONOMER BioCyc EcoCyc:MONOMER0-154 http://biocyc.org/getid?id=EcoCyc:MONOMER0-154 COG COG0650 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0650 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M63654 http://www.ebi.ac.uk/ena/data/view/M63654 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- EchoBASE EB3963 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3963 EcoGene EG14211 http://www.ecogene.org/geneInfo.php?eg_id=EG14211 EnsemblBacteria AAC75536 http://www.ensemblgenomes.org/id/AAC75536 EnsemblBacteria AAC75536 http://www.ensemblgenomes.org/id/AAC75536 EnsemblBacteria BAA16361 http://www.ensemblgenomes.org/id/BAA16361 EnsemblBacteria BAA16361 http://www.ensemblgenomes.org/id/BAA16361 EnsemblBacteria BAA16361 http://www.ensemblgenomes.org/id/BAA16361 EnsemblBacteria b2483 http://www.ensemblgenomes.org/id/b2483 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0055114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 947492 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947492 HOGENOM HOG000228277 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000228277&db=HOGENOM6 InParanoid P77858 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77858 IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR001694 http://www.ebi.ac.uk/interpro/entry/IPR001694 InterPro IPR018086 http://www.ebi.ac.uk/interpro/entry/IPR018086 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2468 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2468 KEGG_Gene eco:b2483 http://www.genome.jp/dbget-bin/www_bget?eco:b2483 KEGG_Orthology KO:K12138 http://www.genome.jp/dbget-bin/www_bget?KO:K12138 OMA AKMHSRQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AKMHSRQ PANTHER PTHR11432 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11432 PROSITE PS00668 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00668 PSORT swissprot:HYFC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HYFC_ECOLI PSORT-B swissprot:HYFC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HYFC_ECOLI PSORT2 swissprot:HYFC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HYFC_ECOLI Pfam PF00146 http://pfam.xfam.org/family/PF00146 Phobius swissprot:HYFC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HYFC_ECOLI PhylomeDB P77858 http://phylomedb.org/?seqid=P77858 ProteinModelPortal P77858 http://www.proteinmodelportal.org/query/uniprot/P77858 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416978 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416978 RefSeq WP_001311024 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001311024 STRING 511145.b2483 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2483&targetmode=cogs STRING COG0650 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0650&targetmode=cogs TCDB 3.D.1.9 http://www.tcdb.org/search/result.php?tc=3.D.1.9 UniProtKB HYFC_ECOLI http://www.uniprot.org/uniprot/HYFC_ECOLI UniProtKB-AC P77858 http://www.uniprot.org/uniprot/P77858 charge swissprot:HYFC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HYFC_ECOLI eggNOG COG0650 http://eggnogapi.embl.de/nog_data/html/tree/COG0650 eggNOG ENOG4107TDF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107TDF epestfind swissprot:HYFC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HYFC_ECOLI garnier swissprot:HYFC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HYFC_ECOLI helixturnhelix swissprot:HYFC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HYFC_ECOLI hmoment swissprot:HYFC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HYFC_ECOLI iep swissprot:HYFC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HYFC_ECOLI inforesidue swissprot:HYFC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HYFC_ECOLI octanol swissprot:HYFC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HYFC_ECOLI pepcoil swissprot:HYFC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HYFC_ECOLI pepdigest swissprot:HYFC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HYFC_ECOLI pepinfo swissprot:HYFC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HYFC_ECOLI pepnet swissprot:HYFC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HYFC_ECOLI pepstats swissprot:HYFC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HYFC_ECOLI pepwheel swissprot:HYFC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HYFC_ECOLI pepwindow swissprot:HYFC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HYFC_ECOLI sigcleave swissprot:HYFC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HYFC_ECOLI ## Database ID URL or Descriptions # BioGrid 4261965 13 # EcoGene EG12212 yhhL # InterPro IPR009525 DUF1145 # Organism YHHL_ECOLI Escherichia coli (strain K12) # PATRIC 32122376 VBIEscCol129921_3565 # PIR E65143 E65143 # Pfam PF06611 DUF1145 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHHL_ECOLI Uncharacterized protein YhhL # RefSeq NP_417923 NC_000913.3 # RefSeq WP_001311191 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18441.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # eggNOG COG3776 LUCA # eggNOG ENOG4105MG3 Bacteria BLAST swissprot:YHHL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHHL_ECOLI BioCyc ECOL316407:JW5683-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5683-MONOMER BioCyc EcoCyc:EG12212-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12212-MONOMER COG COG3776 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3776 DOI 10.1007/BF02428043 http://dx.doi.org/10.1007/BF02428043 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X04398 http://www.ebi.ac.uk/ena/data/view/X04398 EchoBASE EB2126 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2126 EcoGene EG12212 http://www.ecogene.org/geneInfo.php?eg_id=EG12212 EnsemblBacteria AAC76491 http://www.ensemblgenomes.org/id/AAC76491 EnsemblBacteria AAC76491 http://www.ensemblgenomes.org/id/AAC76491 EnsemblBacteria BAE77827 http://www.ensemblgenomes.org/id/BAE77827 EnsemblBacteria BAE77827 http://www.ensemblgenomes.org/id/BAE77827 EnsemblBacteria BAE77827 http://www.ensemblgenomes.org/id/BAE77827 EnsemblBacteria b3466 http://www.ensemblgenomes.org/id/b3466 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947976 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947976 HOGENOM HOG000001825 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000001825&db=HOGENOM6 IntAct P37614 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37614* InterPro IPR009525 http://www.ebi.ac.uk/interpro/entry/IPR009525 KEGG_Gene ecj:JW5683 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5683 KEGG_Gene eco:b3466 http://www.genome.jp/dbget-bin/www_bget?eco:b3466 KEGG_Orthology KO:K08993 http://www.genome.jp/dbget-bin/www_bget?KO:K08993 OMA NLIHPFP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NLIHPFP PSORT swissprot:YHHL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHHL_ECOLI PSORT-B swissprot:YHHL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHHL_ECOLI PSORT2 swissprot:YHHL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHHL_ECOLI Pfam PF06611 http://pfam.xfam.org/family/PF06611 Phobius swissprot:YHHL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHHL_ECOLI ProteinModelPortal P37614 http://www.proteinmodelportal.org/query/uniprot/P37614 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3025556 http://www.ncbi.nlm.nih.gov/pubmed/3025556 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417923 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417923 RefSeq WP_001311191 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001311191 SMR P37614 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37614 STRING 511145.b3466 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3466&targetmode=cogs STRING COG3776 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3776&targetmode=cogs UniProtKB YHHL_ECOLI http://www.uniprot.org/uniprot/YHHL_ECOLI UniProtKB-AC P37614 http://www.uniprot.org/uniprot/P37614 charge swissprot:YHHL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHHL_ECOLI eggNOG COG3776 http://eggnogapi.embl.de/nog_data/html/tree/COG3776 eggNOG ENOG4105MG3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105MG3 epestfind swissprot:YHHL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHHL_ECOLI garnier swissprot:YHHL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHHL_ECOLI helixturnhelix swissprot:YHHL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHHL_ECOLI hmoment swissprot:YHHL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHHL_ECOLI iep swissprot:YHHL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHHL_ECOLI inforesidue swissprot:YHHL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHHL_ECOLI octanol swissprot:YHHL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHHL_ECOLI pepcoil swissprot:YHHL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHHL_ECOLI pepdigest swissprot:YHHL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHHL_ECOLI pepinfo swissprot:YHHL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHHL_ECOLI pepnet swissprot:YHHL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHHL_ECOLI pepstats swissprot:YHHL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHHL_ECOLI pepwheel swissprot:YHHL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHHL_ECOLI pepwindow swissprot:YHHL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHHL_ECOLI sigcleave swissprot:YHHL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHHL_ECOLI ## Database ID URL or Descriptions # AltName ARNB_ECOLI Polymyxin resistance protein PmrH # AltName ARNB_ECOLI UDP-(beta-L-threo-pentapyranosyl-4''-ulose diphosphate) aminotransferase # AltName ARNB_ECOLI UDP-4-amino-4-deoxy-L-arabinose aminotransferase # BRENDA 2.6.1.87 2026 # BioGrid 4259180 233 # CATALYTIC ACTIVITY UDP-4-amino-4-deoxy-beta-L-arabinose + 2- oxoglutarate = UDP-beta-L-threo-pentapyranos-4-ulose + L- glutamate. {ECO:0000269|PubMed 12704196}. # CDD cd00616 AHBA_syn # COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI 597326; # EcoGene EG14089 arnB # FUNCTION ARNB_ECOLI Catalyzes the conversion of UDP-4-keto-arabinose (UDP- Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. {ECO 0000269|PubMed 12704196}. # GO_component GO:0005737 cytoplasm; NAS:EcoCyc. # GO_function GO:0008483 transaminase activity; IDA:EcoCyc. # GO_function GO:0030170 pyridoxal phosphate binding; IDA:EcoCyc. # GO_function GO:0099621 undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase activity; IEA:UniProtKB-EC. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0009245 lipid A biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.640.10 -; 1. # Gene3D 3.90.1150.10 -; 1. # HAMAP MF_01167 ArnB_transfer # INDUCTION Induced by BasR. {ECO:0000250|UniProtKB Q8ZNF3}. # InterPro IPR000653 DegT/StrS_aminotransferase # InterPro IPR015421 PyrdxlP-dep_Trfase_major_sub1 # InterPro IPR015422 PyrdxlP-dep_Trfase_major_sub2 # InterPro IPR015424 PyrdxlP-dep_Trfase # InterPro IPR022850 ArnB_NH2Trfase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # KEGG_Brite ko01007 Amino acid related enzymes # KEGG_Pathway ko00520 Amino sugar and nucleotide sugar metabolism # KEGG_Pathway ko02020 Two-component system # Organism ARNB_ECOLI Escherichia coli (strain K12) # PATHWAY Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. {ECO:0000269|PubMed 17928292}. # PATHWAY Nucleotide-sugar biosynthesis; UDP-4-deoxy-4-formamido- beta-L-arabinose biosynthesis; UDP-4-deoxy-4-formamido-beta-L- arabinose from UDP-alpha-D-glucuronate: step 2/3. {ECO 0000269|PubMed:17928292}. # PATRIC 32119871 VBIEscCol129921_2345 # PIR C64996 C64996 # PIRSF PIRSF000390 PLP_StrS # Pfam PF01041 DegT_DnrJ_EryC1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ARNB_ECOLI UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase # RefSeq NP_416756 NC_000913.3 # RefSeq WP_001295286 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAC75313.3; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily. {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000250|UniProtKB Q8ZNF3}. # SUPFAM SSF53383 SSF53383 # UniPathway UPA00032 UER00493 # eggNOG COG0399 LUCA # eggNOG ENOG4105CF4 Bacteria BLAST swissprot:ARNB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARNB_ECOLI BioCyc ECOL316407:JW5372-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5372-MONOMER BioCyc EcoCyc:G7166-MONOMER http://biocyc.org/getid?id=EcoCyc:G7166-MONOMER BioCyc MetaCyc:G7166-MONOMER http://biocyc.org/getid?id=MetaCyc:G7166-MONOMER COG COG0399 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0399 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M304043200 http://dx.doi.org/10.1074/jbc.M304043200 DOI 10.1074/jbc.M706172200 http://dx.doi.org/10.1074/jbc.M706172200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.6.1.87 {ECO:0000269|PubMed:12704196} http://www.genome.jp/dbget-bin/www_bget?EC:2.6.1.87 {ECO:0000269|PubMed:12704196} EMBL AF527386 http://www.ebi.ac.uk/ena/data/view/AF527386 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.6.1.87 {ECO:0000269|PubMed:12704196} http://enzyme.expasy.org/EC/2.6.1.87 {ECO:0000269|PubMed:12704196} EchoBASE EB3842 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3842 EcoGene EG14089 http://www.ecogene.org/geneInfo.php?eg_id=EG14089 EnsemblBacteria AAC75313 http://www.ensemblgenomes.org/id/AAC75313 EnsemblBacteria AAC75313 http://www.ensemblgenomes.org/id/AAC75313 EnsemblBacteria BAA16076 http://www.ensemblgenomes.org/id/BAA16076 EnsemblBacteria BAA16076 http://www.ensemblgenomes.org/id/BAA16076 EnsemblBacteria BAA16076 http://www.ensemblgenomes.org/id/BAA16076 EnsemblBacteria b2253 http://www.ensemblgenomes.org/id/b2253 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0008483 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008483 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_function GO:0099621 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0099621 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GO_process GO:0009245 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009245 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.640.10 http://www.cathdb.info/version/latest/superfamily/3.40.640.10 Gene3D 3.90.1150.10 http://www.cathdb.info/version/latest/superfamily/3.90.1150.10 GeneID 947375 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947375 HAMAP MF_01167 http://hamap.expasy.org/unirule/MF_01167 HOGENOM HOG000230163 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230163&db=HOGENOM6 InParanoid P77690 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77690 IntEnz 2.6.1.87 {ECO:0000269|PubMed:12704196} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.6.1.87 {ECO:0000269|PubMed:12704196} InterPro IPR000653 http://www.ebi.ac.uk/interpro/entry/IPR000653 InterPro IPR015421 http://www.ebi.ac.uk/interpro/entry/IPR015421 InterPro IPR015422 http://www.ebi.ac.uk/interpro/entry/IPR015422 InterPro IPR015424 http://www.ebi.ac.uk/interpro/entry/IPR015424 InterPro IPR022850 http://www.ebi.ac.uk/interpro/entry/IPR022850 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Gene ecj:JW5372 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5372 KEGG_Gene eco:b2253 http://www.genome.jp/dbget-bin/www_bget?eco:b2253 KEGG_Orthology KO:K07806 http://www.genome.jp/dbget-bin/www_bget?KO:K07806 KEGG_Pathway ko00520 http://www.genome.jp/kegg-bin/show_pathway?ko00520 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 KEGG_Reaction rn:R07659 http://www.genome.jp/dbget-bin/www_bget?rn:R07659 OMA SEWNSAR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SEWNSAR PSORT swissprot:ARNB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARNB_ECOLI PSORT-B swissprot:ARNB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARNB_ECOLI PSORT2 swissprot:ARNB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARNB_ECOLI Pfam PF01041 http://pfam.xfam.org/family/PF01041 Phobius swissprot:ARNB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARNB_ECOLI PhylomeDB P77690 http://phylomedb.org/?seqid=P77690 ProteinModelPortal P77690 http://www.proteinmodelportal.org/query/uniprot/P77690 PubMed 12704196 http://www.ncbi.nlm.nih.gov/pubmed/12704196 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17928292 http://www.ncbi.nlm.nih.gov/pubmed/17928292 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416756 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416756 RefSeq WP_001295286 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295286 SMR P77690 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77690 STRING 511145.b2253 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2253&targetmode=cogs STRING COG0399 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0399&targetmode=cogs SUPFAM SSF53383 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53383 UniProtKB ARNB_ECOLI http://www.uniprot.org/uniprot/ARNB_ECOLI UniProtKB-AC P77690 http://www.uniprot.org/uniprot/P77690 charge swissprot:ARNB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARNB_ECOLI eggNOG COG0399 http://eggnogapi.embl.de/nog_data/html/tree/COG0399 eggNOG ENOG4105CF4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CF4 epestfind swissprot:ARNB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARNB_ECOLI garnier swissprot:ARNB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARNB_ECOLI helixturnhelix swissprot:ARNB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARNB_ECOLI hmoment swissprot:ARNB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARNB_ECOLI iep swissprot:ARNB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARNB_ECOLI inforesidue swissprot:ARNB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARNB_ECOLI octanol swissprot:ARNB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARNB_ECOLI pepcoil swissprot:ARNB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARNB_ECOLI pepdigest swissprot:ARNB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARNB_ECOLI pepinfo swissprot:ARNB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARNB_ECOLI pepnet swissprot:ARNB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARNB_ECOLI pepstats swissprot:ARNB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARNB_ECOLI pepwheel swissprot:ARNB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARNB_ECOLI pepwindow swissprot:ARNB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARNB_ECOLI sigcleave swissprot:ARNB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARNB_ECOLI ## Database ID URL or Descriptions # BRENDA 2.1.1.229 2026 # BioGrid 4261069 5 # CATALYTIC ACTIVITY MNMC_ECOLI S-adenosyl-L-methionine + tRNA containing 5- aminomethyl-2-thiouridine = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate. # COFACTOR MNMC_ECOLI Name=FAD; Xref=ChEBI CHEBI 57692; Evidence={ECO 0000269|PubMed 15247431, ECO 0000269|PubMed 18186482}; # EcoGene EG14114 mnmC # FUNCTION MNMC_ECOLI Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34. {ECO 0000269|PubMed 15247431, ECO 0000269|PubMed 18186482}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0004808 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity; IDA:EcoCyc. # GO_function GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors; IEA:InterPro. # GO_function GO:0071949 FAD binding; IDA:EcoCyc. # GO_process GO:0002098 tRNA wobble uridine modification; IMP:EcoCyc. # GO_process GO:0030488 tRNA methylation; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0008168 methyltransferase activity # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # Gene3D 3.40.50.150 -; 1. # Gene3D 3.50.50.60 -; 3. # HAMAP MF_01102 MnmC # InterPro IPR006076 FAD-dep_OxRdtase # InterPro IPR008471 MnmC-like_methylTransf # InterPro IPR017610 tRNA_S-uridine_synth_MnmC_C # InterPro IPR023032 tRNA_MAMT_biosynth_bifunc_MnmC # InterPro IPR023753 FAD/NAD-binding_dom # InterPro IPR029063 SAM-dependent_MTases # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # Organism MNMC_ECOLI Escherichia coli (strain K12) # PATRIC 32120021 VBIEscCol129921_2420 # PDB 3AWI X-ray; 3.00 A; A/B/C/D/E/F=1-668 # PIR B65005 B65005 # Pfam PF01266 DAO # Pfam PF05430 Methyltransf_30 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MNMC_ECOLI FAD-dependent cmnm(5)s(2)U34 oxidoreductase # RecName MNMC_ECOLI tRNA (mnm(5)s(2)U34)-methyltransferase # RecName MNMC_ECOLI tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC # RefSeq NP_416827 NC_000913.3 # RefSeq WP_000683799 NZ_LN832404.1 # SIMILARITY In the C-terminal section; belongs to the DAO family. {ECO 0000305}. # SIMILARITY In the N-terminal section; belongs to the methyltransferase superfamily. tRNA (mnm(5)s(2)U34)- methyltransferase family. {ECO 0000305}. # SUBCELLULAR LOCATION MNMC_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF51905 SSF51905 # TIGRFAMs TIGR03197 MnmC_Cterm # eggNOG COG0665 LUCA # eggNOG COG4121 LUCA # eggNOG ENOG4105CWG Bacteria BLAST swissprot:MNMC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MNMC_ECOLI BioCyc ECOL316407:JW5380-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5380-MONOMER BioCyc EcoCyc:G7199-MONOMER http://biocyc.org/getid?id=EcoCyc:G7199-MONOMER BioCyc MetaCyc:G7199-MONOMER http://biocyc.org/getid?id=MetaCyc:G7199-MONOMER COG COG0665 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0665 COG COG4121 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4121 DIP DIP-28058N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-28058N DOI 10.1002/prot.21918 http://dx.doi.org/10.1002/prot.21918 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1261/rna.7470904 http://dx.doi.org/10.1261/rna.7470904 EC_number EC:1.5.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.5.-.- EC_number EC:2.1.1.61 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.61 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.5.-.- http://enzyme.expasy.org/EC/1.5.-.- ENZYME 2.1.1.61 http://enzyme.expasy.org/EC/2.1.1.61 EchoBASE EB3867 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3867 EcoGene EG14114 http://www.ecogene.org/geneInfo.php?eg_id=EG14114 EnsemblBacteria AAC75384 http://www.ensemblgenomes.org/id/AAC75384 EnsemblBacteria AAC75384 http://www.ensemblgenomes.org/id/AAC75384 EnsemblBacteria BAA16181 http://www.ensemblgenomes.org/id/BAA16181 EnsemblBacteria BAA16181 http://www.ensemblgenomes.org/id/BAA16181 EnsemblBacteria BAA16181 http://www.ensemblgenomes.org/id/BAA16181 EnsemblBacteria b2324 http://www.ensemblgenomes.org/id/b2324 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004808 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004808 GO_function GO:0016645 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016645 GO_function GO:0071949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071949 GO_process GO:0002098 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002098 GO_process GO:0030488 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030488 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 GeneID 946800 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946800 HAMAP MF_01102 http://hamap.expasy.org/unirule/MF_01102 HOGENOM HOG000218142 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218142&db=HOGENOM6 InParanoid P77182 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77182 IntAct P77182 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77182* IntEnz 1.5 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.5 IntEnz 2.1.1.61 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.61 InterPro IPR006076 http://www.ebi.ac.uk/interpro/entry/IPR006076 InterPro IPR008471 http://www.ebi.ac.uk/interpro/entry/IPR008471 InterPro IPR017610 http://www.ebi.ac.uk/interpro/entry/IPR017610 InterPro IPR023032 http://www.ebi.ac.uk/interpro/entry/IPR023032 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW5380 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5380 KEGG_Gene eco:b2324 http://www.genome.jp/dbget-bin/www_bget?eco:b2324 KEGG_Orthology KO:K15461 http://www.genome.jp/dbget-bin/www_bget?KO:K15461 OMA KSVLCYD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KSVLCYD PDB 3AWI http://www.ebi.ac.uk/pdbe-srv/view/entry/3AWI PDBsum 3AWI http://www.ebi.ac.uk/pdbsum/3AWI PSORT swissprot:MNMC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MNMC_ECOLI PSORT-B swissprot:MNMC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MNMC_ECOLI PSORT2 swissprot:MNMC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MNMC_ECOLI Pfam PF01266 http://pfam.xfam.org/family/PF01266 Pfam PF05430 http://pfam.xfam.org/family/PF05430 Phobius swissprot:MNMC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MNMC_ECOLI PhylomeDB P77182 http://phylomedb.org/?seqid=P77182 ProteinModelPortal P77182 http://www.proteinmodelportal.org/query/uniprot/P77182 PubMed 15247431 http://www.ncbi.nlm.nih.gov/pubmed/15247431 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18186482 http://www.ncbi.nlm.nih.gov/pubmed/18186482 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416827 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416827 RefSeq WP_000683799 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000683799 SMR P77182 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77182 STRING 511145.b2324 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2324&targetmode=cogs STRING COG0665 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0665&targetmode=cogs STRING COG4121 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4121&targetmode=cogs SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 TIGRFAMs TIGR03197 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03197 UniProtKB MNMC_ECOLI http://www.uniprot.org/uniprot/MNMC_ECOLI UniProtKB-AC P77182 http://www.uniprot.org/uniprot/P77182 charge swissprot:MNMC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MNMC_ECOLI eggNOG COG0665 http://eggnogapi.embl.de/nog_data/html/tree/COG0665 eggNOG COG4121 http://eggnogapi.embl.de/nog_data/html/tree/COG4121 eggNOG ENOG4105CWG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CWG epestfind swissprot:MNMC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MNMC_ECOLI garnier swissprot:MNMC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MNMC_ECOLI helixturnhelix swissprot:MNMC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MNMC_ECOLI hmoment swissprot:MNMC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MNMC_ECOLI iep swissprot:MNMC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MNMC_ECOLI inforesidue swissprot:MNMC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MNMC_ECOLI octanol swissprot:MNMC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MNMC_ECOLI pepcoil swissprot:MNMC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MNMC_ECOLI pepdigest swissprot:MNMC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MNMC_ECOLI pepinfo swissprot:MNMC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MNMC_ECOLI pepnet swissprot:MNMC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MNMC_ECOLI pepstats swissprot:MNMC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MNMC_ECOLI pepwheel swissprot:MNMC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MNMC_ECOLI pepwindow swissprot:MNMC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MNMC_ECOLI sigcleave swissprot:MNMC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MNMC_ECOLI ## Database ID URL or Descriptions # AltName 4'-phosphopantetheinyl transferase AcpS {ECO:0000255|HAMAP-Rule MF_00101} # BRENDA 2.7.8 2026 # BioGrid 4260598 286 # CATALYTIC ACTIVITY ACPS_ECOLI CoA-(4'-phosphopantetheine) + apo-[acyl- carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl- carrier-protein]. {ECO 0000255|HAMAP-Rule MF_00101, ECO 0000269|PubMed 7559576}. # COFACTOR ACPS_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_00101, ECO 0000269|PubMed 7559576}; # EcoGene EG10247 acpS # FUNCTION ACPS_ECOLI Transfers the 4'-phosphopantetheine moiety from coenzyme A to the 'Ser-36' of acyl-carrier-protein. {ECO 0000269|PubMed 7559576}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008897 holo-[acyl-carrier-protein] synthase activity; IDA:EcoliWiki. # GO_function GO:0016740 transferase activity; TAS:EcoliWiki. # GO_process GO:0006633 fatty acid biosynthetic process; NAS:EcoliWiki. # GO_process GO:0018070 peptidyl-serine phosphopantetheinylation; IDA:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.90.470.20 -; 1. # HAMAP MF_00101 AcpS # IntAct P24224 13 # InterPro IPR002582 ACPS # InterPro IPR004568 Ppantetheine-prot_Trfase_dom # InterPro IPR008278 4-PPantetheinyl_Trfase_SF # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00770 Pantothenate and CoA biosynthesis # MASS SPECTROMETRY Mass=13950; Method=Electrospray; Range=2-126; Evidence={ECO:0000269|PubMed 7559576}; # Organism ACPS_ECOLI Escherichia coli (strain K12) # PATRIC 32120525 VBIEscCol129921_2665 # PIR B42294 B42294 # Pfam PF01648 ACPS # ProDom PD004282 PPantethiene-prot_Trfase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Holo-[acyl-carrier-protein] synthase {ECO:0000255|HAMAP-Rule MF_00101} # RefSeq NP_417058 NC_000913.3 # RefSeq WP_000986023 NZ_LN832404.1 # SIMILARITY Belongs to the P-Pant transferase superfamily. AcpS family. {ECO:0000255|HAMAP-Rule MF_00101}. # SUBCELLULAR LOCATION ACPS_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 7559576}. # SUPFAM SSF56214 SSF56214 # TIGRFAMs TIGR00516 acpS # TIGRFAMs TIGR00556 pantethn_trn # eggNOG COG0736 LUCA # eggNOG ENOG4105KJV Bacteria BLAST swissprot:ACPS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ACPS_ECOLI BioCyc ECOL316407:JW2547-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2547-MONOMER BioCyc EcoCyc:HOLO-ACP-SYNTH-MONOMER http://biocyc.org/getid?id=EcoCyc:HOLO-ACP-SYNTH-MONOMER BioCyc MetaCyc:HOLO-ACP-SYNTH-MONOMER http://biocyc.org/getid?id=MetaCyc:HOLO-ACP-SYNTH-MONOMER COG COG0736 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0736 DIP DIP-9047N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9047N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.270.42.24658 http://dx.doi.org/10.1074/jbc.270.42.24658 DOI 10.1074/jbc.275.2.959 http://dx.doi.org/10.1074/jbc.275.2.959 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.8.7 {ECO:0000255|HAMAP-Rule:MF_00101} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.8.7 {ECO:0000255|HAMAP-Rule:MF_00101} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D64044 http://www.ebi.ac.uk/ena/data/view/D64044 EMBL M74526 http://www.ebi.ac.uk/ena/data/view/M74526 EMBL M76470 http://www.ebi.ac.uk/ena/data/view/M76470 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36841 http://www.ebi.ac.uk/ena/data/view/U36841 ENZYME 2.7.8.7 {ECO:0000255|HAMAP-Rule:MF_00101} http://enzyme.expasy.org/EC/2.7.8.7 {ECO:0000255|HAMAP-Rule:MF_00101} EchoBASE EB0243 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0243 EcoGene EG10247 http://www.ecogene.org/geneInfo.php?eg_id=EG10247 EnsemblBacteria AAC75616 http://www.ensemblgenomes.org/id/AAC75616 EnsemblBacteria AAC75616 http://www.ensemblgenomes.org/id/AAC75616 EnsemblBacteria BAE76739 http://www.ensemblgenomes.org/id/BAE76739 EnsemblBacteria BAE76739 http://www.ensemblgenomes.org/id/BAE76739 EnsemblBacteria BAE76739 http://www.ensemblgenomes.org/id/BAE76739 EnsemblBacteria b2563 http://www.ensemblgenomes.org/id/b2563 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0008897 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008897 GO_function GO:0016740 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016740 GO_process GO:0006633 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006633 GO_process GO:0018070 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018070 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.90.470.20 http://www.cathdb.info/version/latest/superfamily/3.90.470.20 GeneID 947037 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947037 HAMAP MF_00101 http://hamap.expasy.org/unirule/MF_00101 HOGENOM HOG000014316 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000014316&db=HOGENOM6 InParanoid P24224 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P24224 IntAct P24224 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P24224* IntEnz 2.7.8.7 {ECO:0000255|HAMAP-Rule:MF_00101} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.8.7 {ECO:0000255|HAMAP-Rule:MF_00101} InterPro IPR002582 http://www.ebi.ac.uk/interpro/entry/IPR002582 InterPro IPR004568 http://www.ebi.ac.uk/interpro/entry/IPR004568 InterPro IPR008278 http://www.ebi.ac.uk/interpro/entry/IPR008278 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2547 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2547 KEGG_Gene eco:b2563 http://www.genome.jp/dbget-bin/www_bget?eco:b2563 KEGG_Orthology KO:K00997 http://www.genome.jp/dbget-bin/www_bget?KO:K00997 KEGG_Pathway ko00770 http://www.genome.jp/kegg-bin/show_pathway?ko00770 KEGG_Reaction rn:R01625 http://www.genome.jp/dbget-bin/www_bget?rn:R01625 MINT MINT-1256571 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1256571 OMA AQGVFWR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AQGVFWR PSORT swissprot:ACPS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ACPS_ECOLI PSORT-B swissprot:ACPS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ACPS_ECOLI PSORT2 swissprot:ACPS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ACPS_ECOLI Pfam PF01648 http://pfam.xfam.org/family/PF01648 Phobius swissprot:ACPS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ACPS_ECOLI PhylomeDB P24224 http://phylomedb.org/?seqid=P24224 ProteinModelPortal P24224 http://www.proteinmodelportal.org/query/uniprot/P24224 PubMed 10625633 http://www.ncbi.nlm.nih.gov/pubmed/10625633 PubMed 1537799 http://www.ncbi.nlm.nih.gov/pubmed/1537799 PubMed 1537800 http://www.ncbi.nlm.nih.gov/pubmed/1537800 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7559576 http://www.ncbi.nlm.nih.gov/pubmed/7559576 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417058 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417058 RefSeq WP_000986023 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000986023 SMR P24224 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P24224 STRING 511145.b2563 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2563&targetmode=cogs STRING COG0736 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0736&targetmode=cogs SUPFAM SSF56214 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56214 TIGRFAMs TIGR00516 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00516 TIGRFAMs TIGR00556 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00556 UniProtKB ACPS_ECOLI http://www.uniprot.org/uniprot/ACPS_ECOLI UniProtKB-AC P24224 http://www.uniprot.org/uniprot/P24224 charge swissprot:ACPS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ACPS_ECOLI eggNOG COG0736 http://eggnogapi.embl.de/nog_data/html/tree/COG0736 eggNOG ENOG4105KJV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KJV epestfind swissprot:ACPS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ACPS_ECOLI garnier swissprot:ACPS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ACPS_ECOLI helixturnhelix swissprot:ACPS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ACPS_ECOLI hmoment swissprot:ACPS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ACPS_ECOLI iep swissprot:ACPS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ACPS_ECOLI inforesidue swissprot:ACPS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ACPS_ECOLI octanol swissprot:ACPS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ACPS_ECOLI pepcoil swissprot:ACPS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ACPS_ECOLI pepdigest swissprot:ACPS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ACPS_ECOLI pepinfo swissprot:ACPS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ACPS_ECOLI pepnet swissprot:ACPS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ACPS_ECOLI pepstats swissprot:ACPS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ACPS_ECOLI pepwheel swissprot:ACPS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ACPS_ECOLI pepwindow swissprot:ACPS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ACPS_ECOLI sigcleave swissprot:ACPS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ACPS_ECOLI ## Database ID URL or Descriptions # AltName NADH dehydrogenase I subunit C/D {ECO:0000255|HAMAP-Rule MF_01359} # AltName NDH-1 subunit C/D {ECO:0000255|HAMAP-Rule MF_01359} # AltName NUOCD_ECOLI NUO3/NUO4 # BioGrid 4262976 21 # CATALYTIC ACTIVITY NADH + a quinone = NAD(+) + a quinol. {ECO:0000255|HAMAP-Rule MF_01359}. # EcoGene EG12084 nuoC # FUNCTION NUOCD_ECOLI NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. # GO_component GO:0005886 plasma membrane; IDA:EcoliWiki. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_component GO:0030964 NADH dehydrogenase complex; IDA:EcoliWiki. # GO_component GO:0045272 plasma membrane respiratory chain complex I; IDA:EcoCyc. # GO_function GO:0008137 NADH dehydrogenase (ubiquinone) activity; IMP:EcoCyc. # GO_function GO:0048038 quinone binding; IEA:UniProtKB-KW. # GO_function GO:0051287 NAD binding; IEA:InterPro. # GO_process GO:0006810 transport; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006810 transport # Gene3D 1.10.645.10 -; 1. # HAMAP MF_01357 NDH1_NuoC # HAMAP MF_01358 NDH1_NuoD # HAMAP MF_01359 NDH1_NuoCD_1 # INTERACTION NUOCD_ECOLI P33602 nuoG; NbExp=2; IntAct=EBI-552399, EBI-559737; # IntAct P33599 6 # InterPro IPR001135 NADH_Q_OxRdtase_suD # InterPro IPR001268 NADH_UbQ_OxRdtase_30kDa_su # InterPro IPR010218 NADH_DH_suC # InterPro IPR014029 NADH_UbQ_OxRdtase_49kDa_CS # InterPro IPR020396 NADH_UbQ_OxRdtase_CS # InterPro IPR022885 NDH1_su_D/H # InterPro IPR023062 NADH_DH_suCD # InterPro IPR029014 NiFe_Hase-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00190 Oxidative phosphorylation # KEGG_Pathway ko00910 Nitrogen metabolism # Organism NUOCD_ECOLI Escherichia coli (strain K12) # PATRIC 32119939 VBIEscCol129921_2379 # PIR D65000 D65000 # PROSITE PS00535 COMPLEX1_49K # PROSITE PS00542 COMPLEX1_30K # Pfam PF00329 Complex1_30kDa # Pfam PF00346 Complex1_49kDa # ProDom PD001581 NADH_UbQ_OxRdtase_30kDa_su # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NADH-quinone oxidoreductase subunit C/D {ECO:0000255|HAMAP-Rule MF_01359} # RefSeq NP_416789 NC_000913.3 # RefSeq WP_001384057 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA03535.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA16115.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=CAA48363.1; Type=Frameshift; Positions=175; Evidence={ECO:0000305}; # SIMILARITY In the C-terminal section; belongs to the complex I 49 kDa subunit family. {ECO:0000255|HAMAP-Rule MF_01359}. # SIMILARITY In the N-terminal section; belongs to the complex I 30 kDa subunit family. {ECO:0000255|HAMAP-Rule MF_01359}. # SUBCELLULAR LOCATION NUOCD_ECOLI Cytoplasm {ECO 0000269|PubMed 16079137}. Cell inner membrane {ECO 0000255|HAMAP-Rule MF_01359, ECO 0000269|PubMed 16079137}; Peripheral membrane protein {ECO 0000255|HAMAP-Rule MF_01359, ECO 0000269|PubMed 16079137}. # SUBUNIT NUOCD_ECOLI NDH-1 is composed of 13 different subunits. Subunits NuoB, CD, E, F, and G constitute the peripheral sector of the complex. # SUPFAM SSF56762 SSF56762 # TCDB 3.D.1.1 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family # TIGRFAMs TIGR01961 NuoC_fam # TIGRFAMs TIGR01962 NuoD # eggNOG COG0649 LUCA # eggNOG COG0852 LUCA # eggNOG ENOG4105CQV Bacteria BLAST swissprot:NUOCD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NUOCD_ECOLI BioCyc ECOL316407:JW5375-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5375-MONOMER BioCyc EcoCyc:NUOC-MONOMER http://biocyc.org/getid?id=EcoCyc:NUOC-MONOMER BioCyc MetaCyc:NUOC-MONOMER http://biocyc.org/getid?id=MetaCyc:NUOC-MONOMER COG COG0649 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0649 COG COG0852 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0852 DIP DIP-10380N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10380N DOI 10.1006/jmbi.1993.1488 http://dx.doi.org/10.1006/jmbi.1993.1488 DOI 10.1016/S0005-2728(01)00248-1 http://dx.doi.org/10.1016/S0005-2728(01)00248-1 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1432-1033.1995.tb20594.x http://dx.doi.org/10.1111/j.1432-1033.1995.tb20594.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.6.5.11 {ECO:0000255|HAMAP-Rule:MF_01359} http://www.genome.jp/dbget-bin/www_bget?EC:1.6.5.11 {ECO:0000255|HAMAP-Rule:MF_01359} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L25055 http://www.ebi.ac.uk/ena/data/view/L25055 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X68301 http://www.ebi.ac.uk/ena/data/view/X68301 EMBL X68301 http://www.ebi.ac.uk/ena/data/view/X68301 ENZYME 1.6.5.11 {ECO:0000255|HAMAP-Rule:MF_01359} http://enzyme.expasy.org/EC/1.6.5.11 {ECO:0000255|HAMAP-Rule:MF_01359} EchoBASE EB2009 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2009 EcoGene EG12084 http://www.ecogene.org/geneInfo.php?eg_id=EG12084 EnsemblBacteria AAC75346 http://www.ensemblgenomes.org/id/AAC75346 EnsemblBacteria AAC75346 http://www.ensemblgenomes.org/id/AAC75346 EnsemblBacteria BAA16115 http://www.ensemblgenomes.org/id/BAA16115 EnsemblBacteria BAA16115 http://www.ensemblgenomes.org/id/BAA16115 EnsemblBacteria BAA16115 http://www.ensemblgenomes.org/id/BAA16115 EnsemblBacteria b2286 http://www.ensemblgenomes.org/id/b2286 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0030964 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030964 GO_component GO:0045272 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045272 GO_function GO:0008137 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008137 GO_function GO:0048038 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048038 GO_function GO:0051287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051287 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 1.10.645.10 http://www.cathdb.info/version/latest/superfamily/1.10.645.10 GeneID 946759 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946759 HAMAP MF_01357 http://hamap.expasy.org/unirule/MF_01357 HAMAP MF_01358 http://hamap.expasy.org/unirule/MF_01358 HAMAP MF_01359 http://hamap.expasy.org/unirule/MF_01359 HOGENOM HOG000228264 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000228264&db=HOGENOM6 InParanoid P33599 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33599 IntAct P33599 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33599* IntEnz 1.6.5.11 {ECO:0000255|HAMAP-Rule:MF_01359} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.6.5.11 {ECO:0000255|HAMAP-Rule:MF_01359} InterPro IPR001135 http://www.ebi.ac.uk/interpro/entry/IPR001135 InterPro IPR001268 http://www.ebi.ac.uk/interpro/entry/IPR001268 InterPro IPR010218 http://www.ebi.ac.uk/interpro/entry/IPR010218 InterPro IPR014029 http://www.ebi.ac.uk/interpro/entry/IPR014029 InterPro IPR020396 http://www.ebi.ac.uk/interpro/entry/IPR020396 InterPro IPR022885 http://www.ebi.ac.uk/interpro/entry/IPR022885 InterPro IPR023062 http://www.ebi.ac.uk/interpro/entry/IPR023062 InterPro IPR029014 http://www.ebi.ac.uk/interpro/entry/IPR029014 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5375 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5375 KEGG_Gene eco:b2286 http://www.genome.jp/dbget-bin/www_bget?eco:b2286 KEGG_Orthology KO:K13378 http://www.genome.jp/dbget-bin/www_bget?KO:K13378 KEGG_Pathway ko00190 http://www.genome.jp/kegg-bin/show_pathway?ko00190 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 MINT MINT-1269278 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1269278 OMA PVFYMFT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PVFYMFT PROSITE PS00535 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00535 PROSITE PS00542 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00542 PSORT swissprot:NUOCD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NUOCD_ECOLI PSORT-B swissprot:NUOCD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NUOCD_ECOLI PSORT2 swissprot:NUOCD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NUOCD_ECOLI Pfam PF00329 http://pfam.xfam.org/family/PF00329 Pfam PF00346 http://pfam.xfam.org/family/PF00346 Phobius swissprot:NUOCD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NUOCD_ECOLI PhylomeDB P33599 http://phylomedb.org/?seqid=P33599 ProteinModelPortal P33599 http://www.proteinmodelportal.org/query/uniprot/P33599 PubMed 11997136 http://www.ncbi.nlm.nih.gov/pubmed/11997136 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7607227 http://www.ncbi.nlm.nih.gov/pubmed/7607227 PubMed 7690854 http://www.ncbi.nlm.nih.gov/pubmed/7690854 PubMed 8157582 http://www.ncbi.nlm.nih.gov/pubmed/8157582 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416789 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416789 RefSeq WP_001384057 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001384057 SMR P33599 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33599 STRING 511145.b2286 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2286&targetmode=cogs STRING COG0649 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0649&targetmode=cogs STRING COG0852 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0852&targetmode=cogs SUPFAM SSF56762 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56762 TCDB 3.D.1.1 http://www.tcdb.org/search/result.php?tc=3.D.1.1 TIGRFAMs TIGR01961 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01961 TIGRFAMs TIGR01962 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01962 UniProtKB NUOCD_ECOLI http://www.uniprot.org/uniprot/NUOCD_ECOLI UniProtKB-AC P33599 http://www.uniprot.org/uniprot/P33599 charge swissprot:NUOCD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NUOCD_ECOLI eggNOG COG0649 http://eggnogapi.embl.de/nog_data/html/tree/COG0649 eggNOG COG0852 http://eggnogapi.embl.de/nog_data/html/tree/COG0852 eggNOG ENOG4105CQV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CQV epestfind swissprot:NUOCD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NUOCD_ECOLI garnier swissprot:NUOCD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NUOCD_ECOLI helixturnhelix swissprot:NUOCD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NUOCD_ECOLI hmoment swissprot:NUOCD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NUOCD_ECOLI iep swissprot:NUOCD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NUOCD_ECOLI inforesidue swissprot:NUOCD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NUOCD_ECOLI octanol swissprot:NUOCD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NUOCD_ECOLI pepcoil swissprot:NUOCD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NUOCD_ECOLI pepdigest swissprot:NUOCD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NUOCD_ECOLI pepinfo swissprot:NUOCD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NUOCD_ECOLI pepnet swissprot:NUOCD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NUOCD_ECOLI pepstats swissprot:NUOCD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NUOCD_ECOLI pepwheel swissprot:NUOCD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NUOCD_ECOLI pepwindow swissprot:NUOCD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NUOCD_ECOLI sigcleave swissprot:NUOCD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NUOCD_ECOLI ## Database ID URL or Descriptions # BioGrid 4263028 7 # CATALYTIC ACTIVITY NADA_ECOLI Glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H(2)O + phosphate. # COFACTOR NADA_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000269|PubMed 15898769, ECO 0000269|PubMed 15967443}; Note=Binds 1 [4Fe-4S] cluster per subunit. {ECO 0000269|PubMed 15898769, ECO 0000269|PubMed 15967443}; # ENZYME REGULATION NADA_ECOLI Activity is greater under oxic conditions and is regulated by a redox-active disulfide bond. # EcoGene EG10630 nadA # FUNCTION NADA_ECOLI Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. {ECO 0000269|PubMed 10648170, ECO 0000269|PubMed 15898769, ECO 0000269|PubMed 15967443}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008987 quinolinate synthetase A activity; IDA:EcoCyc. # GO_function GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups; IEA:InterPro. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IDA:EcoCyc. # GO_process GO:0034628 'de novo' NAD biosynthetic process from aspartate; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0051186 cofactor metabolic process # HAMAP MF_00567 NadA_type1 # IntAct P11458 6 # InterPro IPR003473 NadA # InterPro IPR023513 Quinolinate_synth_A_type1 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00760 Nicotinate and nicotinamide metabolism # MASS SPECTROMETRY Mass=38246; Method=MALDI; Range=1-347; Evidence={ECO:0000269|PubMed 10648170}; # Organism NADA_ECOLI Escherichia coli (strain K12) # PATHWAY Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate step 1/1. # PATRIC 32116699 VBIEscCol129921_0775 # PIR F64810 SYECQA # Pfam PF02445 NadA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NADA_ECOLI Quinolinate synthase A # RefSeq NP_415271 NC_000913.3 # RefSeq WP_000115290 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA31216.1; Type=Frameshift; Positions=12, 304; Evidence={ECO 0000305}; # SIMILARITY Belongs to the quinolinate synthase A family. Type 1 subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION NADA_ECOLI Cytoplasm. # SUBUNIT Homodimer. {ECO:0000269|PubMed 15967443}. # TIGRFAMs TIGR00550 nadA # UniPathway UPA00253 UER00327 # eggNOG COG0379 LUCA # eggNOG ENOG4105D0I Bacteria BLAST swissprot:NADA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NADA_ECOLI BioCyc ECOL316407:JW0733-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0733-MONOMER BioCyc EcoCyc:QUINOLINATE-SYNTHA-MONOMER http://biocyc.org/getid?id=EcoCyc:QUINOLINATE-SYNTHA-MONOMER BioCyc MetaCyc:QUINOLINATE-SYNTHA-MONOMER http://biocyc.org/getid?id=MetaCyc:QUINOLINATE-SYNTHA-MONOMER COG COG0379 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0379 DIP DIP-1027N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-1027N DOI 10.1006/prep.1999.1153 http://dx.doi.org/10.1006/prep.1999.1153 DOI 10.1016/j.febslet.2005.05.065 http://dx.doi.org/10.1016/j.febslet.2005.05.065 DOI 10.1021/bi801135y http://dx.doi.org/10.1021/bi801135y DOI 10.1021/ja051369x http://dx.doi.org/10.1021/ja051369x DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1432-1033.1988.tb14187.x http://dx.doi.org/10.1111/j.1432-1033.1988.tb14187.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.5.1.72 http://www.genome.jp/dbget-bin/www_bget?EC:2.5.1.72 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X12713 http://www.ebi.ac.uk/ena/data/view/X12713 ENZYME 2.5.1.72 http://enzyme.expasy.org/EC/2.5.1.72 EchoBASE EB0624 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0624 EcoGene EG10630 http://www.ecogene.org/geneInfo.php?eg_id=EG10630 EnsemblBacteria AAC73837 http://www.ensemblgenomes.org/id/AAC73837 EnsemblBacteria AAC73837 http://www.ensemblgenomes.org/id/AAC73837 EnsemblBacteria BAA35409 http://www.ensemblgenomes.org/id/BAA35409 EnsemblBacteria BAA35409 http://www.ensemblgenomes.org/id/BAA35409 EnsemblBacteria BAA35409 http://www.ensemblgenomes.org/id/BAA35409 EnsemblBacteria b0750 http://www.ensemblgenomes.org/id/b0750 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008987 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008987 GO_function GO:0016765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016765 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0034628 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034628 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016765 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GeneID 945351 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945351 HAMAP MF_00567 http://hamap.expasy.org/unirule/MF_00567 HOGENOM HOG000222769 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000222769&db=HOGENOM6 InParanoid P11458 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P11458 IntAct P11458 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P11458* IntEnz 2.5.1.72 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.5.1.72 InterPro IPR003473 http://www.ebi.ac.uk/interpro/entry/IPR003473 InterPro IPR023513 http://www.ebi.ac.uk/interpro/entry/IPR023513 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0733 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0733 KEGG_Gene eco:b0750 http://www.genome.jp/dbget-bin/www_bget?eco:b0750 KEGG_Orthology KO:K03517 http://www.genome.jp/dbget-bin/www_bget?KO:K03517 KEGG_Pathway ko00760 http://www.genome.jp/kegg-bin/show_pathway?ko00760 KEGG_Reaction rn:R04292 http://www.genome.jp/dbget-bin/www_bget?rn:R04292 OMA IAHPECE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IAHPECE PSORT swissprot:NADA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NADA_ECOLI PSORT-B swissprot:NADA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NADA_ECOLI PSORT2 swissprot:NADA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NADA_ECOLI Pfam PF02445 http://pfam.xfam.org/family/PF02445 Phobius swissprot:NADA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NADA_ECOLI PhylomeDB P11458 http://phylomedb.org/?seqid=P11458 ProteinModelPortal P11458 http://www.proteinmodelportal.org/query/uniprot/P11458 PubMed 10648170 http://www.ncbi.nlm.nih.gov/pubmed/10648170 PubMed 15898769 http://www.ncbi.nlm.nih.gov/pubmed/15898769 PubMed 15967443 http://www.ncbi.nlm.nih.gov/pubmed/15967443 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18651751 http://www.ncbi.nlm.nih.gov/pubmed/18651751 PubMed 2841129 http://www.ncbi.nlm.nih.gov/pubmed/2841129 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415271 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415271 RefSeq WP_000115290 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000115290 SMR P11458 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P11458 STRING 511145.b0750 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0750&targetmode=cogs STRING COG0379 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0379&targetmode=cogs TIGRFAMs TIGR00550 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00550 UniProtKB NADA_ECOLI http://www.uniprot.org/uniprot/NADA_ECOLI UniProtKB-AC P11458 http://www.uniprot.org/uniprot/P11458 charge swissprot:NADA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NADA_ECOLI eggNOG COG0379 http://eggnogapi.embl.de/nog_data/html/tree/COG0379 eggNOG ENOG4105D0I http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D0I epestfind swissprot:NADA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NADA_ECOLI garnier swissprot:NADA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NADA_ECOLI helixturnhelix swissprot:NADA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NADA_ECOLI hmoment swissprot:NADA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NADA_ECOLI iep swissprot:NADA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NADA_ECOLI inforesidue swissprot:NADA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NADA_ECOLI octanol swissprot:NADA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NADA_ECOLI pepcoil swissprot:NADA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NADA_ECOLI pepdigest swissprot:NADA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NADA_ECOLI pepinfo swissprot:NADA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NADA_ECOLI pepnet swissprot:NADA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NADA_ECOLI pepstats swissprot:NADA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NADA_ECOLI pepwheel swissprot:NADA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NADA_ECOLI pepwindow swissprot:NADA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NADA_ECOLI sigcleave swissprot:NADA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NADA_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES YIGB_ECOLI Kinetic parameters KM=20 uM for 5-amino-6-(5-phospho-D-ribitylamino)uracil {ECO 0000269|PubMed 24123841}; KM=1 mM for FMN (with magnesium ions as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; Vmax=4 umol/min/mg enzyme with 5-amino-6-(5-phospho-D- ribitylamino)uracil as substrate {ECO 0000269|PubMed 24123841}; pH dependence Optimum pH is 6-7.5. {ECO 0000269|PubMed 16990279}; # BioGrid 4263283 13 # CATALYTIC ACTIVITY 5-amino-6-(5-phospho-D-ribitylamino)uracil + H(2)O = 5-amino-6-(D-ribitylamino)uracil + phosphate. {ECO:0000269|PubMed 24123841}. # COFACTOR YIGB_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 16990279}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 16990279}; Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000269|PubMed 16990279}; Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 16990279}; Note=Magnesium. Can also use other divalent metal cations as manganese, cobalt or zinc. {ECO 0000269|PubMed 16990279}; # DISRUPTION PHENOTYPE Cells lacking this gene can grow in the absence of exogenous riboflavin; this may be due to the presence of the functionally redundant protein YbjI. {ECO:0000269|PubMed 24123841}. # EcoGene EG11202 yigB # FUNCTION YIGB_ECOLI Catalyzes the dephosphorylation of 5-amino-6-(5-phospho- D-ribitylamino)uracil, and thus could be involved in the riboflavin biosynthesis pathway (PubMed 24123841). Is also able to dephosphorylate flavin mononucleotide (FMN) and other phosphoric acid esters (PubMed 16990279) (PubMed 24123841). YigB is important for the formation of dormant persister cells (PubMed 18519731). {ECO 0000269|PubMed 16990279, ECO 0000269|PubMed 18519731, ECO 0000269|PubMed 24123841}. # GO_function GO:0000287 magnesium ion binding; IDA:UniProtKB. # GO_function GO:0016791 phosphatase activity; IDA:EcoCyc. # GO_function GO:0043726 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity; IDA:EcoCyc. # GO_process GO:0009231 riboflavin biosynthetic process; IDA:EcoCyc. # GO_process GO:0022611 dormancy process; IMP:EcoCyc. # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.1000 -; 1. # InterPro IPR006439 HAD-SF_hydro_IA # InterPro IPR023214 HAD-like_dom # Organism YIGB_ECOLI Escherichia coli (strain K12) # PATHWAY Cofactor biosynthesis; riboflavin biosynthesis; 5-amino- 6-(D-ribitylamino)uracil from GTP: step 4/4. {ECO 0000305|PubMed:24123841}. # PATRIC 32123125 VBIEscCol129921_3928 # PIR D37841 D37841 # Pfam PF13419 HAD_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase YigB {ECO:0000303|PubMed 24123841} # RefSeq NP_418257 NC_000913.3 # RefSeq WP_001213584 NZ_LN832404.1 # SIMILARITY Belongs to the HAD-like hydrolase superfamily. {ECO 0000305}. # SUPFAM SSF56784 SSF56784 # TIGRFAMs TIGR01549 HAD-SF-IA-v1 # UniPathway UPA00275 UER00403 # eggNOG COG1011 LUCA # eggNOG ENOG4105DFC Bacteria BLAST swissprot:YIGB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIGB_ECOLI BioCyc ECOL316407:JW3785-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3785-MONOMER BioCyc EcoCyc:EG11202-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11202-MONOMER BioCyc MetaCyc:EG11202-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11202-MONOMER COG COG1011 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1011 DIP DIP-48086N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48086N DOI 10.1002/cbic.201300544 http://dx.doi.org/10.1002/cbic.201300544 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M605449200 http://dx.doi.org/10.1074/jbc.M605449200 DOI 10.1093/nar/11.24.8625 http://dx.doi.org/10.1093/nar/11.24.8625 DOI 10.1093/nar/12.14.5789 http://dx.doi.org/10.1093/nar/12.14.5789 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AAC.00144-08 http://dx.doi.org/10.1128/AAC.00144-08 EC_number EC:3.1.3.- {ECO:0000269|PubMed:24123841} http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.- {ECO:0000269|PubMed:24123841} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M38257 http://www.ebi.ac.uk/ena/data/view/M38257 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X00738 http://www.ebi.ac.uk/ena/data/view/X00738 ENZYME 3.1.3.- {ECO:0000269|PubMed:24123841} http://enzyme.expasy.org/EC/3.1.3.- {ECO:0000269|PubMed:24123841} EchoBASE EB1187 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1187 EcoGene EG11202 http://www.ecogene.org/geneInfo.php?eg_id=EG11202 EnsemblBacteria AAC76815 http://www.ensemblgenomes.org/id/AAC76815 EnsemblBacteria AAC76815 http://www.ensemblgenomes.org/id/AAC76815 EnsemblBacteria BAE77488 http://www.ensemblgenomes.org/id/BAE77488 EnsemblBacteria BAE77488 http://www.ensemblgenomes.org/id/BAE77488 EnsemblBacteria BAE77488 http://www.ensemblgenomes.org/id/BAE77488 EnsemblBacteria b3812 http://www.ensemblgenomes.org/id/b3812 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GO_function GO:0043726 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043726 GO_process GO:0009231 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009231 GO_process GO:0022611 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022611 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.1000 http://www.cathdb.info/version/latest/superfamily/3.40.50.1000 GeneID 948357 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948357 HOGENOM HOG000248345 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000248345&db=HOGENOM6 InParanoid P0ADP0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADP0 IntEnz 3.1.3.- {ECO:0000269|PubMed:24123841} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.- {ECO:0000269|PubMed:24123841} InterPro IPR006439 http://www.ebi.ac.uk/interpro/entry/IPR006439 InterPro IPR023214 http://www.ebi.ac.uk/interpro/entry/IPR023214 KEGG_Gene ecj:JW3785 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3785 KEGG_Gene eco:b3812 http://www.genome.jp/dbget-bin/www_bget?eco:b3812 KEGG_Orthology KO:K07025 http://www.genome.jp/dbget-bin/www_bget?KO:K07025 OMA YHPALRD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YHPALRD PSORT swissprot:YIGB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIGB_ECOLI PSORT-B swissprot:YIGB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIGB_ECOLI PSORT2 swissprot:YIGB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIGB_ECOLI Pfam PF13419 http://pfam.xfam.org/family/PF13419 Phobius swissprot:YIGB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIGB_ECOLI PhylomeDB P0ADP0 http://phylomedb.org/?seqid=P0ADP0 ProteinModelPortal P0ADP0 http://www.proteinmodelportal.org/query/uniprot/P0ADP0 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16990279 http://www.ncbi.nlm.nih.gov/pubmed/16990279 PubMed 18519731 http://www.ncbi.nlm.nih.gov/pubmed/18519731 PubMed 2254268 http://www.ncbi.nlm.nih.gov/pubmed/2254268 PubMed 24123841 http://www.ncbi.nlm.nih.gov/pubmed/24123841 PubMed 6324092 http://www.ncbi.nlm.nih.gov/pubmed/6324092 PubMed 6379604 http://www.ncbi.nlm.nih.gov/pubmed/6379604 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418257 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418257 RefSeq WP_001213584 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001213584 SMR P0ADP0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADP0 STRING 511145.b3812 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3812&targetmode=cogs STRING COG1011 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1011&targetmode=cogs SUPFAM SSF56784 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784 TIGRFAMs TIGR01549 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01549 UniProtKB YIGB_ECOLI http://www.uniprot.org/uniprot/YIGB_ECOLI UniProtKB-AC P0ADP0 http://www.uniprot.org/uniprot/P0ADP0 charge swissprot:YIGB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIGB_ECOLI eggNOG COG1011 http://eggnogapi.embl.de/nog_data/html/tree/COG1011 eggNOG ENOG4105DFC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DFC epestfind swissprot:YIGB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIGB_ECOLI garnier swissprot:YIGB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIGB_ECOLI helixturnhelix swissprot:YIGB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIGB_ECOLI hmoment swissprot:YIGB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIGB_ECOLI iep swissprot:YIGB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIGB_ECOLI inforesidue swissprot:YIGB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIGB_ECOLI octanol swissprot:YIGB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIGB_ECOLI pepcoil swissprot:YIGB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIGB_ECOLI pepdigest swissprot:YIGB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIGB_ECOLI pepinfo swissprot:YIGB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIGB_ECOLI pepnet swissprot:YIGB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIGB_ECOLI pepstats swissprot:YIGB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIGB_ECOLI pepwheel swissprot:YIGB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIGB_ECOLI pepwindow swissprot:YIGB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIGB_ECOLI sigcleave swissprot:YIGB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIGB_ECOLI ## Database ID URL or Descriptions # CAUTION There is no equivalent of this gene in strain K12 / MG1655. {ECO 0000305}. # FUNCTION INH12_ECOLI Involved in the transposition of the insertion sequence IS5. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # InterPro IPR002559 Transposase_11 # InterPro IPR008490 Transposase_InsH_N # Organism INH12_ECOLI Escherichia coli (strain K12) # Pfam PF01609 DDE_Tnp_1 # Pfam PF05598 DUF772 # RecName INH12_ECOLI Transposase InsH for insertion sequence element IS5-12 # SIMILARITY Belongs to the transposase 11 family. {ECO 0000305}. # eggNOG COG3039 LUCA # eggNOG ENOG4105F2I Bacteria BLAST swissprot:INH12_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INH12_ECOLI DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EnsemblBacteria BAA15714 http://www.ensemblgenomes.org/id/BAA15714 EnsemblBacteria BAA15714 http://www.ensemblgenomes.org/id/BAA15714 EnsemblBacteria BAA15714 http://www.ensemblgenomes.org/id/BAA15714 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 InterPro IPR002559 http://www.ebi.ac.uk/interpro/entry/IPR002559 InterPro IPR008490 http://www.ebi.ac.uk/interpro/entry/IPR008490 KEGG_Gene ecj:JW1882 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1882 PSORT swissprot:INH12_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INH12_ECOLI PSORT-B swissprot:INH12_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INH12_ECOLI PSORT2 swissprot:INH12_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INH12_ECOLI Pfam PF01609 http://pfam.xfam.org/family/PF01609 Pfam PF05598 http://pfam.xfam.org/family/PF05598 Phobius swissprot:INH12_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INH12_ECOLI PhylomeDB P0CE59 http://phylomedb.org/?seqid=P0CE59 ProteinModelPortal P0CE59 http://www.proteinmodelportal.org/query/uniprot/P0CE59 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 SMR P0CE59 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0CE59 STRING 511145.b3505 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3505&targetmode=cogs UniProtKB INH12_ECOLI http://www.uniprot.org/uniprot/INH12_ECOLI UniProtKB-AC P0CE59 http://www.uniprot.org/uniprot/P0CE59 charge swissprot:INH12_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INH12_ECOLI eggNOG COG3039 http://eggnogapi.embl.de/nog_data/html/tree/COG3039 eggNOG ENOG4105F2I http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F2I epestfind swissprot:INH12_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INH12_ECOLI garnier swissprot:INH12_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INH12_ECOLI helixturnhelix swissprot:INH12_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INH12_ECOLI hmoment swissprot:INH12_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INH12_ECOLI iep swissprot:INH12_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INH12_ECOLI inforesidue swissprot:INH12_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INH12_ECOLI octanol swissprot:INH12_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INH12_ECOLI pepcoil swissprot:INH12_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INH12_ECOLI pepdigest swissprot:INH12_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INH12_ECOLI pepinfo swissprot:INH12_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INH12_ECOLI pepnet swissprot:INH12_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INH12_ECOLI pepstats swissprot:INH12_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INH12_ECOLI pepwheel swissprot:INH12_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INH12_ECOLI pepwindow swissprot:INH12_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INH12_ECOLI sigcleave swissprot:INH12_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INH12_ECOLI ## Database ID URL or Descriptions # BioGrid 4262228 207 # CATALYTIC ACTIVITY DPO3A_ECOLI Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). # EcoGene EG10238 dnaE # FUNCTION DPO3A_ECOLI DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0044776 DNA polymerase III, core complex; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_function GO:0003887 DNA-directed DNA polymerase activity; IDA:EcoliWiki. # GO_process GO:0006260 DNA replication; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0009058 biosynthetic process # INTERACTION DPO3A_ECOLI P0A988 dnaN; NbExp=17; IntAct=EBI-549111, EBI-542385; P03007 dnaQ; NbExp=20; IntAct=EBI-549111, EBI-549131; P06710 dnaX; NbExp=10; IntAct=EBI-549111, EBI-549140; P28630 holA; NbExp=4; IntAct=EBI-549111, EBI-549153; # IntAct P10443 69 # InterPro IPR003141 Pol/His_phosphatase_N # InterPro IPR004013 PHP_dom # InterPro IPR004365 NA-bd_OB_tRNA # InterPro IPR004805 PolC_alpha # InterPro IPR011708 DNA_pol3_alpha # InterPro IPR016195 Pol/histidinol_Pase-like # InterPro IPR029460 DNAPol_HHH # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03032 DNA replication proteins # KEGG_Brite ko03032 M00260 DNA polymerase III complex, bacteria # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Brite ko03400 M00260 DNA polymerase III complex, bacteria # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00240 Pyrimidine metabolism # KEGG_Pathway ko03030 DNA replication # KEGG_Pathway ko03430 Mismatch repair # KEGG_Pathway ko03440 Homologous recombination # Organism DPO3A_ECOLI Escherichia coli (strain K12) # PATRIC 32115479 VBIEscCol129921_0191 # PDB 2HNH X-ray; 2.30 A; A=1-910 # PDB 2HQA X-ray; 2.60 A; A=1-917 # PDB 4GX8 X-ray; 1.70 A; A/B/C/D=1-270 # PDB 4GX9 X-ray; 2.15 A; A/B/C/D=1-270 # PDB 4JOM X-ray; 2.90 A; A=1-917 # PDB 5FKU EM; 8.34 A; A=1-1160 # PDB 5FKV EM; 8.00 A; A=1-1160 # PDB 5FKW EM; 7.30 A; A=1-1160 # PIR C28390 DJEC3A # Pfam PF01336 tRNA_anti-codon # Pfam PF02811 PHP # Pfam PF07733 DNA_pol3_alpha # Pfam PF14579 HHH_6 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DPO3A_ECOLI DNA polymerase III subunit alpha # RefSeq NP_414726 NC_000913.3 # RefSeq WP_001294757 NZ_LN832404.1 # SIMILARITY Belongs to the DNA polymerase type-C family. DnaE subfamily. {ECO 0000305}. # SMART SM00481 POLIIIAc # SUBCELLULAR LOCATION DPO3A_ECOLI Cytoplasm. # SUBUNIT The DNA polymerase holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential subassemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core (subunits alpha,epsilon and theta) contains the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork. This complex contains delta, delta', psi and chi, and copies of either or both of two different DnaX proteins, gamma and tau. The composition of the holoenzyme is, therefore (alpha,epsilon,theta)[2]-(gamma/tau)[3]-delta,delta', psi,chi- beta[4]. # SUPFAM SSF89550 SSF89550 # TIGRFAMs TIGR00594 polc # eggNOG COG0587 LUCA # eggNOG ENOG4105C0B Bacteria BLAST swissprot:DPO3A_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DPO3A_ECOLI BioCyc ECOL316407:JW0179-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0179-MONOMER BioCyc EcoCyc:EG10238-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10238-MONOMER BioCyc MetaCyc:EG10238-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10238-MONOMER COG COG0587 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0587 DIP DIP-9458N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9458N DOI 10.1002/bies.950140206 http://dx.doi.org/10.1002/bies.950140206 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.7.7 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.7 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D49445 http://www.ebi.ac.uk/ena/data/view/D49445 EMBL M19334 http://www.ebi.ac.uk/ena/data/view/M19334 EMBL M96394 http://www.ebi.ac.uk/ena/data/view/M96394 EMBL S52931 http://www.ebi.ac.uk/ena/data/view/S52931 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 ENZYME 2.7.7.7 http://enzyme.expasy.org/EC/2.7.7.7 EchoBASE EB0234 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0234 EcoGene EG10238 http://www.ecogene.org/geneInfo.php?eg_id=EG10238 EnsemblBacteria AAC73295 http://www.ensemblgenomes.org/id/AAC73295 EnsemblBacteria AAC73295 http://www.ensemblgenomes.org/id/AAC73295 EnsemblBacteria BAA77859 http://www.ensemblgenomes.org/id/BAA77859 EnsemblBacteria BAA77859 http://www.ensemblgenomes.org/id/BAA77859 EnsemblBacteria BAA77859 http://www.ensemblgenomes.org/id/BAA77859 EnsemblBacteria b0184 http://www.ensemblgenomes.org/id/b0184 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0044776 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044776 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003887 GO_process GO:0006260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 944877 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944877 HOGENOM HOG000021784 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000021784&db=HOGENOM6 InParanoid P10443 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P10443 IntAct P10443 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P10443* IntEnz 2.7.7.7 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.7 InterPro IPR003141 http://www.ebi.ac.uk/interpro/entry/IPR003141 InterPro IPR004013 http://www.ebi.ac.uk/interpro/entry/IPR004013 InterPro IPR004365 http://www.ebi.ac.uk/interpro/entry/IPR004365 InterPro IPR004805 http://www.ebi.ac.uk/interpro/entry/IPR004805 InterPro IPR011708 http://www.ebi.ac.uk/interpro/entry/IPR011708 InterPro IPR016195 http://www.ebi.ac.uk/interpro/entry/IPR016195 InterPro IPR029460 http://www.ebi.ac.uk/interpro/entry/IPR029460 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03032 http://www.genome.jp/dbget-bin/www_bget?ko03032 KEGG_Brite ko03032 http://www.genome.jp/dbget-bin/www_bget?ko03032 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW0179 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0179 KEGG_Gene eco:b0184 http://www.genome.jp/dbget-bin/www_bget?eco:b0184 KEGG_Orthology KO:K02337 http://www.genome.jp/dbget-bin/www_bget?KO:K02337 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Pathway ko03030 http://www.genome.jp/kegg-bin/show_pathway?ko03030 KEGG_Pathway ko03430 http://www.genome.jp/kegg-bin/show_pathway?ko03430 KEGG_Pathway ko03440 http://www.genome.jp/kegg-bin/show_pathway?ko03440 KEGG_Reaction rn:R00375 http://www.genome.jp/dbget-bin/www_bget?rn:R00375 KEGG_Reaction rn:R00376 http://www.genome.jp/dbget-bin/www_bget?rn:R00376 KEGG_Reaction rn:R00377 http://www.genome.jp/dbget-bin/www_bget?rn:R00377 KEGG_Reaction rn:R00378 http://www.genome.jp/dbget-bin/www_bget?rn:R00378 MINT MINT-1224103 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1224103 OMA MKFPGYM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MKFPGYM PDB 2HNH http://www.ebi.ac.uk/pdbe-srv/view/entry/2HNH PDB 2HQA http://www.ebi.ac.uk/pdbe-srv/view/entry/2HQA PDB 4GX8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4GX8 PDB 4GX9 http://www.ebi.ac.uk/pdbe-srv/view/entry/4GX9 PDB 4JOM http://www.ebi.ac.uk/pdbe-srv/view/entry/4JOM PDB 5FKU http://www.ebi.ac.uk/pdbe-srv/view/entry/5FKU PDB 5FKV http://www.ebi.ac.uk/pdbe-srv/view/entry/5FKV PDB 5FKW http://www.ebi.ac.uk/pdbe-srv/view/entry/5FKW PDBsum 2HNH http://www.ebi.ac.uk/pdbsum/2HNH PDBsum 2HQA http://www.ebi.ac.uk/pdbsum/2HQA PDBsum 4GX8 http://www.ebi.ac.uk/pdbsum/4GX8 PDBsum 4GX9 http://www.ebi.ac.uk/pdbsum/4GX9 PDBsum 4JOM http://www.ebi.ac.uk/pdbsum/4JOM PDBsum 5FKU http://www.ebi.ac.uk/pdbsum/5FKU PDBsum 5FKV http://www.ebi.ac.uk/pdbsum/5FKV PDBsum 5FKW http://www.ebi.ac.uk/pdbsum/5FKW PSORT swissprot:DPO3A_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DPO3A_ECOLI PSORT-B swissprot:DPO3A_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DPO3A_ECOLI PSORT2 swissprot:DPO3A_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DPO3A_ECOLI Pfam PF01336 http://pfam.xfam.org/family/PF01336 Pfam PF02811 http://pfam.xfam.org/family/PF02811 Pfam PF07733 http://pfam.xfam.org/family/PF07733 Pfam PF14579 http://pfam.xfam.org/family/PF14579 Phobius swissprot:DPO3A_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DPO3A_ECOLI PhylomeDB P10443 http://phylomedb.org/?seqid=P10443 ProteinModelPortal P10443 http://www.proteinmodelportal.org/query/uniprot/P10443 PubMed 1575709 http://www.ncbi.nlm.nih.gov/pubmed/1575709 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2066347 http://www.ncbi.nlm.nih.gov/pubmed/2066347 PubMed 3316192 http://www.ncbi.nlm.nih.gov/pubmed/3316192 PubMed 7678242 http://www.ncbi.nlm.nih.gov/pubmed/7678242 PubMed 8375647 http://www.ncbi.nlm.nih.gov/pubmed/8375647 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414726 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414726 RefSeq WP_001294757 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001294757 SMART SM00481 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00481 SMR P10443 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P10443 STRING 511145.b0184 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0184&targetmode=cogs STRING COG0587 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0587&targetmode=cogs SUPFAM SSF89550 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF89550 TIGRFAMs TIGR00594 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00594 UniProtKB DPO3A_ECOLI http://www.uniprot.org/uniprot/DPO3A_ECOLI UniProtKB-AC P10443 http://www.uniprot.org/uniprot/P10443 charge swissprot:DPO3A_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DPO3A_ECOLI eggNOG COG0587 http://eggnogapi.embl.de/nog_data/html/tree/COG0587 eggNOG ENOG4105C0B http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C0B epestfind swissprot:DPO3A_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DPO3A_ECOLI garnier swissprot:DPO3A_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DPO3A_ECOLI helixturnhelix swissprot:DPO3A_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DPO3A_ECOLI hmoment swissprot:DPO3A_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DPO3A_ECOLI iep swissprot:DPO3A_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DPO3A_ECOLI inforesidue swissprot:DPO3A_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DPO3A_ECOLI octanol swissprot:DPO3A_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DPO3A_ECOLI pepcoil swissprot:DPO3A_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DPO3A_ECOLI pepdigest swissprot:DPO3A_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DPO3A_ECOLI pepinfo swissprot:DPO3A_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DPO3A_ECOLI pepnet swissprot:DPO3A_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DPO3A_ECOLI pepstats swissprot:DPO3A_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DPO3A_ECOLI pepwheel swissprot:DPO3A_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DPO3A_ECOLI pepwindow swissprot:DPO3A_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DPO3A_ECOLI sigcleave swissprot:DPO3A_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DPO3A_ECOLI ## Database ID URL or Descriptions # BioGrid 4260377 7 # EcoGene EG14273 flhA # FUNCTION FLHA_ECOLI Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0009306 protein secretion; IEA:InterPro. # GO_process GO:0044780 bacterial-type flagellum assembly; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006810 transport # GOslim_process GO:0022607 cellular component assembly # InterPro IPR001712 T3SS_FHIPEP # InterPro IPR006301 FlhA # InterPro IPR025505 FHIPEP_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko02040 Flagellar assembly # Organism FLHA_ECOLI Escherichia coli (strain K12) # PATRIC 32119083 VBIEscCol129921_1959 # PIR G64950 G64950 # PIRSF PIRSF005419 FlhA # PRINTS PR00949 TYPE3IMAPROT # PROSITE PS00994 FHIPEP # Pfam PF00771 FHIPEP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FLHA_ECOLI Flagellar biosynthesis protein FlhA # RefSeq NP_416393 NC_000913.3 # RefSeq WP_000066951 NZ_LN832404.1 # SIMILARITY Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. {ECO 0000305}. # SUBCELLULAR LOCATION FLHA_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # TCDB 1.A.104.1 the proposed flagellar biosynthesis na+ channel, flah (flah) family # TIGRFAMs TIGR01398 FlhA # eggNOG COG1298 LUCA # eggNOG ENOG4105D7B Bacteria BLAST swissprot:FLHA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLHA_ECOLI BioCyc ECOL316407:JW1868-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1868-MONOMER BioCyc EcoCyc:G370-MONOMER http://biocyc.org/getid?id=EcoCyc:G370-MONOMER COG COG1298 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1298 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U88319 http://www.ebi.ac.uk/ena/data/view/U88319 EchoBASE EB4021 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4021 EcoGene EG14273 http://www.ecogene.org/geneInfo.php?eg_id=EG14273 EnsemblBacteria AAC74949 http://www.ensemblgenomes.org/id/AAC74949 EnsemblBacteria AAC74949 http://www.ensemblgenomes.org/id/AAC74949 EnsemblBacteria BAA15688 http://www.ensemblgenomes.org/id/BAA15688 EnsemblBacteria BAA15688 http://www.ensemblgenomes.org/id/BAA15688 EnsemblBacteria BAA15688 http://www.ensemblgenomes.org/id/BAA15688 EnsemblBacteria b1879 http://www.ensemblgenomes.org/id/b1879 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0009306 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009306 GO_process GO:0044780 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044780 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GeneID 946390 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946390 HOGENOM HOG000254014 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000254014&db=HOGENOM6 InParanoid P76298 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76298 IntAct P76298 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76298* InterPro IPR001712 http://www.ebi.ac.uk/interpro/entry/IPR001712 InterPro IPR006301 http://www.ebi.ac.uk/interpro/entry/IPR006301 InterPro IPR025505 http://www.ebi.ac.uk/interpro/entry/IPR025505 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW1868 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1868 KEGG_Gene eco:b1879 http://www.genome.jp/dbget-bin/www_bget?eco:b1879 KEGG_Orthology KO:K02400 http://www.genome.jp/dbget-bin/www_bget?KO:K02400 KEGG_Pathway ko02040 http://www.genome.jp/kegg-bin/show_pathway?ko02040 OMA ETKELGW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ETKELGW PRINTS PR00949 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00949 PROSITE PS00994 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00994 PSORT swissprot:FLHA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLHA_ECOLI PSORT-B swissprot:FLHA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLHA_ECOLI PSORT2 swissprot:FLHA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLHA_ECOLI Pfam PF00771 http://pfam.xfam.org/family/PF00771 Phobius swissprot:FLHA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLHA_ECOLI PhylomeDB P76298 http://phylomedb.org/?seqid=P76298 ProteinModelPortal P76298 http://www.proteinmodelportal.org/query/uniprot/P76298 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416393 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416393 RefSeq WP_000066951 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000066951 SMR P76298 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76298 STRING 511145.b1879 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1879&targetmode=cogs STRING COG1298 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1298&targetmode=cogs TCDB 1.A.104.1 http://www.tcdb.org/search/result.php?tc=1.A.104.1 TIGRFAMs TIGR01398 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01398 UniProtKB FLHA_ECOLI http://www.uniprot.org/uniprot/FLHA_ECOLI UniProtKB-AC P76298 http://www.uniprot.org/uniprot/P76298 charge swissprot:FLHA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLHA_ECOLI eggNOG COG1298 http://eggnogapi.embl.de/nog_data/html/tree/COG1298 eggNOG ENOG4105D7B http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D7B epestfind swissprot:FLHA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLHA_ECOLI garnier swissprot:FLHA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLHA_ECOLI helixturnhelix swissprot:FLHA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLHA_ECOLI hmoment swissprot:FLHA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLHA_ECOLI iep swissprot:FLHA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLHA_ECOLI inforesidue swissprot:FLHA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLHA_ECOLI octanol swissprot:FLHA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLHA_ECOLI pepcoil swissprot:FLHA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLHA_ECOLI pepdigest swissprot:FLHA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLHA_ECOLI pepinfo swissprot:FLHA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLHA_ECOLI pepnet swissprot:FLHA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLHA_ECOLI pepstats swissprot:FLHA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLHA_ECOLI pepwheel swissprot:FLHA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLHA_ECOLI pepwindow swissprot:FLHA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLHA_ECOLI sigcleave swissprot:FLHA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLHA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260714 18 # EcoGene EG12619 ybdF # InterPro IPR007351 YjbR # Organism YBDF_ECOLI Escherichia coli (strain K12) # PATRIC 32116326 VBIEscCol129921_0603 # PIR A64791 A64791 # Pfam PF04237 YjbR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBDF_ECOLI Uncharacterized protein YbdF # RefSeq NP_415111 NC_000913.3 # RefSeq WP_000360951 NZ_LN832404.1 # eggNOG COG2315 LUCA # eggNOG ENOG4105MSB Bacteria BLAST swissprot:YBDF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBDF_ECOLI BioCyc ECOL316407:JW5083-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5083-MONOMER BioCyc EcoCyc:G6324-MONOMER http://biocyc.org/getid?id=EcoCyc:G6324-MONOMER DIP DIP-48140N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48140N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1574-6968.1994.tb07284.x http://dx.doi.org/10.1111/j.1574-6968.1994.tb07284.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D25414 http://www.ebi.ac.uk/ena/data/view/D25414 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U07860 http://www.ebi.ac.uk/ena/data/view/U07860 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB2503 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2503 EcoGene EG12619 http://www.ecogene.org/geneInfo.php?eg_id=EG12619 EnsemblBacteria AAC73680 http://www.ensemblgenomes.org/id/AAC73680 EnsemblBacteria AAC73680 http://www.ensemblgenomes.org/id/AAC73680 EnsemblBacteria BAA35219 http://www.ensemblgenomes.org/id/BAA35219 EnsemblBacteria BAA35219 http://www.ensemblgenomes.org/id/BAA35219 EnsemblBacteria BAA35219 http://www.ensemblgenomes.org/id/BAA35219 EnsemblBacteria b0579 http://www.ensemblgenomes.org/id/b0579 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 948302 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948302 HOGENOM HOG000013133 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000013133&db=HOGENOM6 InParanoid P0AAT2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAT2 InterPro IPR007351 http://www.ebi.ac.uk/interpro/entry/IPR007351 KEGG_Gene ecj:JW5083 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5083 KEGG_Gene eco:b0579 http://www.genome.jp/dbget-bin/www_bget?eco:b0579 OMA ELIDHSY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ELIDHSY PSORT swissprot:YBDF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBDF_ECOLI PSORT-B swissprot:YBDF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBDF_ECOLI PSORT2 swissprot:YBDF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBDF_ECOLI Pfam PF04237 http://pfam.xfam.org/family/PF04237 Phobius swissprot:YBDF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBDF_ECOLI PhylomeDB P0AAT2 http://phylomedb.org/?seqid=P0AAT2 ProteinModelPortal P0AAT2 http://www.proteinmodelportal.org/query/uniprot/P0AAT2 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7813889 http://www.ncbi.nlm.nih.gov/pubmed/7813889 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415111 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415111 RefSeq WP_000360951 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000360951 SMR P0AAT2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAT2 STRING 511145.b0579 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0579&targetmode=cogs UniProtKB YBDF_ECOLI http://www.uniprot.org/uniprot/YBDF_ECOLI UniProtKB-AC P0AAT2 http://www.uniprot.org/uniprot/P0AAT2 charge swissprot:YBDF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBDF_ECOLI eggNOG COG2315 http://eggnogapi.embl.de/nog_data/html/tree/COG2315 eggNOG ENOG4105MSB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105MSB epestfind swissprot:YBDF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBDF_ECOLI garnier swissprot:YBDF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBDF_ECOLI helixturnhelix swissprot:YBDF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBDF_ECOLI hmoment swissprot:YBDF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBDF_ECOLI iep swissprot:YBDF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBDF_ECOLI inforesidue swissprot:YBDF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBDF_ECOLI octanol swissprot:YBDF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBDF_ECOLI pepcoil swissprot:YBDF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBDF_ECOLI pepdigest swissprot:YBDF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBDF_ECOLI pepinfo swissprot:YBDF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBDF_ECOLI pepnet swissprot:YBDF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBDF_ECOLI pepstats swissprot:YBDF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBDF_ECOLI pepwheel swissprot:YBDF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBDF_ECOLI pepwindow swissprot:YBDF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBDF_ECOLI sigcleave swissprot:YBDF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBDF_ECOLI ## Database ID URL or Descriptions # BioGrid 4261113 104 # EcoGene EG13697 ycaM # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0015179 L-amino acid transmembrane transporter activity; IBA:GO_Central. # GO_function GO:0015297 antiporter activity; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # InterPro IPR002293 AA/rel_permease1 # Organism YCAM_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11785 PTHR11785 # PATRIC 32117011 VBIEscCol129921_0930 # PIR B64829 B64829 # PIRSF PIRSF006060 AA_transporter # Pfam PF13520 AA_permease_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCAM_ECOLI Inner membrane transporter YcaM # RefSeq NP_415419 NC_000913.3 # RefSeq WP_000918506 NZ_LN832404.1 # SIMILARITY Belongs to the amino acid-polyamine-organocation (APC) superfamily. {ECO 0000305}. # SUBCELLULAR LOCATION YCAM_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.3.7 the amino acid-polyamine-organocation (apc) family # eggNOG COG0531 LUCA # eggNOG ENOG4105E5D Bacteria BLAST swissprot:YCAM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCAM_ECOLI BioCyc ECOL316407:JW5119-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5119-MONOMER BioCyc EcoCyc:YCAM http://biocyc.org/getid?id=EcoCyc:YCAM DIP DIP-11468N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11468N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3461 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3461 EcoGene EG13697 http://www.ecogene.org/geneInfo.php?eg_id=EG13697 EnsemblBacteria AAC73985 http://www.ensemblgenomes.org/id/AAC73985 EnsemblBacteria AAC73985 http://www.ensemblgenomes.org/id/AAC73985 EnsemblBacteria BAA35634 http://www.ensemblgenomes.org/id/BAA35634 EnsemblBacteria BAA35634 http://www.ensemblgenomes.org/id/BAA35634 EnsemblBacteria BAA35634 http://www.ensemblgenomes.org/id/BAA35634 EnsemblBacteria b0899 http://www.ensemblgenomes.org/id/b0899 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015179 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015179 GO_function GO:0015297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015297 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GeneID 945518 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945518 HOGENOM HOG000057650 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000057650&db=HOGENOM6 InParanoid P75835 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75835 InterPro IPR002293 http://www.ebi.ac.uk/interpro/entry/IPR002293 KEGG_Gene ecj:JW5119 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5119 KEGG_Gene eco:b0899 http://www.genome.jp/dbget-bin/www_bget?eco:b0899 OMA YLAGWTY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YLAGWTY PANTHER PTHR11785 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11785 PSORT swissprot:YCAM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCAM_ECOLI PSORT-B swissprot:YCAM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCAM_ECOLI PSORT2 swissprot:YCAM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCAM_ECOLI Pfam PF13520 http://pfam.xfam.org/family/PF13520 Phobius swissprot:YCAM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCAM_ECOLI PhylomeDB P75835 http://phylomedb.org/?seqid=P75835 ProteinModelPortal P75835 http://www.proteinmodelportal.org/query/uniprot/P75835 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415419 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415419 RefSeq WP_000918506 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000918506 STRING 511145.b0899 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0899&targetmode=cogs TCDB 2.A.3.7 http://www.tcdb.org/search/result.php?tc=2.A.3.7 UniProtKB YCAM_ECOLI http://www.uniprot.org/uniprot/YCAM_ECOLI UniProtKB-AC P75835 http://www.uniprot.org/uniprot/P75835 charge swissprot:YCAM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCAM_ECOLI eggNOG COG0531 http://eggnogapi.embl.de/nog_data/html/tree/COG0531 eggNOG ENOG4105E5D http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E5D epestfind swissprot:YCAM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCAM_ECOLI garnier swissprot:YCAM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCAM_ECOLI helixturnhelix swissprot:YCAM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCAM_ECOLI hmoment swissprot:YCAM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCAM_ECOLI iep swissprot:YCAM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCAM_ECOLI inforesidue swissprot:YCAM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCAM_ECOLI octanol swissprot:YCAM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCAM_ECOLI pepcoil swissprot:YCAM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCAM_ECOLI pepdigest swissprot:YCAM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCAM_ECOLI pepinfo swissprot:YCAM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCAM_ECOLI pepnet swissprot:YCAM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCAM_ECOLI pepstats swissprot:YCAM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCAM_ECOLI pepwheel swissprot:YCAM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCAM_ECOLI pepwindow swissprot:YCAM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCAM_ECOLI sigcleave swissprot:YCAM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCAM_ECOLI ## Database ID URL or Descriptions # BioGrid 4259660 138 # EcoGene EG11435 marR # FUNCTION MARR_ECOLI Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes. Binds to the marO operator/promoter site. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_function GO:0044212 transcription regulatory region DNA binding; IBA:GO_Central. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0009408 response to heat; IMP:EcoCyc. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IMP:EcoCyc. # GO_process GO:0071236 cellular response to antibiotic; IMP:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # INTERACTION MARR_ECOLI P0AES4 gyrA; NbExp=2; IntAct=EBI-6409744, EBI-547129; # InterPro IPR000835 HTH_MarR-typ # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR023187 Tscrpt_reg_MarR-type_CS # KEGG_Brite ko03000 Transcription factors # Organism MARR_ECOLI Escherichia coli (strain K12) # PATRIC 32118358 VBIEscCol129921_1599 # PDB 1JGS X-ray; 2.30 A; A=7-144 # PDB 3VB2 X-ray; 2.60 A; A/B=1-144 # PDB 3VOD X-ray; 2.60 A; A/B=1-144 # PDB 3VOE X-ray; 2.60 A; A/B=1-144 # PDB 4JBA X-ray; 2.50 A; A/B=1-144 # PIR E64907 E64907 # PRINTS PR00598 HTHMARR # PROSITE PS01117 HTH_MARR_1 # PROSITE PS50995 HTH_MARR_2 # Pfam PF01047 MarR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MARR_ECOLI Multiple antibiotic resistance protein MarR # RefSeq NP_416047 NC_000913.3 # RefSeq WP_000843414 NZ_LN832404.1 # SIMILARITY Contains 1 HTH marR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00345}. # SMART SM00347 HTH_MARR # SUPFAM SSF46785 SSF46785 # eggNOG COG1846 LUCA # eggNOG ENOG4108T3F Bacteria BLAST swissprot:MARR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MARR_ECOLI BioCyc ECOL316407:JW5248-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5248-MONOMER BioCyc EcoCyc:PD00364 http://biocyc.org/getid?id=EcoCyc:PD00364 COG COG1846 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1846 DIP DIP-10164N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10164N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2000.01802.x http://dx.doi.org/10.1046/j.1365-2958.2000.01802.x DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M96235 http://www.ebi.ac.uk/ena/data/view/M96235 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1405 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1405 EcoGene EG11435 http://www.ecogene.org/geneInfo.php?eg_id=EG11435 EnsemblBacteria AAC74603 http://www.ensemblgenomes.org/id/AAC74603 EnsemblBacteria AAC74603 http://www.ensemblgenomes.org/id/AAC74603 EnsemblBacteria BAA15220 http://www.ensemblgenomes.org/id/BAA15220 EnsemblBacteria BAA15220 http://www.ensemblgenomes.org/id/BAA15220 EnsemblBacteria BAA15220 http://www.ensemblgenomes.org/id/BAA15220 EnsemblBacteria b1530 http://www.ensemblgenomes.org/id/b1530 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0044212 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044212 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GO_process GO:0071236 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071236 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 945825 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945825 HOGENOM HOG000221449 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000221449&db=HOGENOM6 InParanoid P27245 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P27245 IntAct P27245 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P27245* InterPro IPR000835 http://www.ebi.ac.uk/interpro/entry/IPR000835 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR023187 http://www.ebi.ac.uk/interpro/entry/IPR023187 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW5248 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5248 KEGG_Gene eco:b1530 http://www.genome.jp/dbget-bin/www_bget?eco:b1530 KEGG_Orthology KO:K03712 http://www.genome.jp/dbget-bin/www_bget?KO:K03712 OMA YEATMVT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YEATMVT PDB 1JGS http://www.ebi.ac.uk/pdbe-srv/view/entry/1JGS PDB 3VB2 http://www.ebi.ac.uk/pdbe-srv/view/entry/3VB2 PDB 3VOD http://www.ebi.ac.uk/pdbe-srv/view/entry/3VOD PDB 3VOE http://www.ebi.ac.uk/pdbe-srv/view/entry/3VOE PDB 4JBA http://www.ebi.ac.uk/pdbe-srv/view/entry/4JBA PDBsum 1JGS http://www.ebi.ac.uk/pdbsum/1JGS PDBsum 3VB2 http://www.ebi.ac.uk/pdbsum/3VB2 PDBsum 3VOD http://www.ebi.ac.uk/pdbsum/3VOD PDBsum 3VOE http://www.ebi.ac.uk/pdbsum/3VOE PDBsum 4JBA http://www.ebi.ac.uk/pdbsum/4JBA PRINTS PR00598 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00598 PROSITE PS01117 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01117 PROSITE PS50995 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50995 PSORT swissprot:MARR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MARR_ECOLI PSORT-B swissprot:MARR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MARR_ECOLI PSORT2 swissprot:MARR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MARR_ECOLI Pfam PF01047 http://pfam.xfam.org/family/PF01047 Phobius swissprot:MARR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MARR_ECOLI PhylomeDB P27245 http://phylomedb.org/?seqid=P27245 ProteinModelPortal P27245 http://www.proteinmodelportal.org/query/uniprot/P27245 PubMed 10760140 http://www.ncbi.nlm.nih.gov/pubmed/10760140 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7768850 http://www.ncbi.nlm.nih.gov/pubmed/7768850 PubMed 8282690 http://www.ncbi.nlm.nih.gov/pubmed/8282690 PubMed 8383113 http://www.ncbi.nlm.nih.gov/pubmed/8383113 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416047 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416047 RefSeq WP_000843414 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000843414 SMART SM00347 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00347 SMR P27245 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P27245 STRING 511145.b1530 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1530&targetmode=cogs STRING COG1846 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1846&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB MARR_ECOLI http://www.uniprot.org/uniprot/MARR_ECOLI UniProtKB-AC P27245 http://www.uniprot.org/uniprot/P27245 charge swissprot:MARR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MARR_ECOLI eggNOG COG1846 http://eggnogapi.embl.de/nog_data/html/tree/COG1846 eggNOG ENOG4108T3F http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108T3F epestfind swissprot:MARR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MARR_ECOLI garnier swissprot:MARR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MARR_ECOLI helixturnhelix swissprot:MARR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MARR_ECOLI hmoment swissprot:MARR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MARR_ECOLI iep swissprot:MARR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MARR_ECOLI inforesidue swissprot:MARR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MARR_ECOLI octanol swissprot:MARR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MARR_ECOLI pepcoil swissprot:MARR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MARR_ECOLI pepdigest swissprot:MARR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MARR_ECOLI pepinfo swissprot:MARR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MARR_ECOLI pepnet swissprot:MARR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MARR_ECOLI pepstats swissprot:MARR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MARR_ECOLI pepwheel swissprot:MARR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MARR_ECOLI pepwindow swissprot:MARR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MARR_ECOLI sigcleave swissprot:MARR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MARR_ECOLI ## Database ID URL or Descriptions # FUNCTION TRAE1_ECOLI Involved in F pilus assembly. # GO_process GO:0000746 conjugation; IEA:UniProtKB-KW. # GOslim_process GO:0008150 biological_process # InterPro IPR007973 Pilus_assembly_TraE # Organism TRAE1_ECOLI Escherichia coli (strain K12) # PIR C29332 BVECTE # Pfam PF05309 TraE # RecName TRAE1_ECOLI Protein TraE # RefSeq NP_061455 NC_002483.1 # RefSeq WP_000399792 NZ_CP014273.1 # SIMILARITY Belongs to the TraE family. {ECO 0000305}. # TIGRFAMs TIGR02761 TraE_TIGR BLAST swissprot:TRAE1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRAE1_ECOLI EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL K01147 http://www.ebi.ac.uk/ena/data/view/K01147 EMBL U01159 http://www.ebi.ac.uk/ena/data/view/U01159 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0000746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000746 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 1263497 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263497 InterPro IPR007973 http://www.ebi.ac.uk/interpro/entry/IPR007973 OMA NIDNNQK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NIDNNQK PSORT swissprot:TRAE1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRAE1_ECOLI PSORT-B swissprot:TRAE1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRAE1_ECOLI PSORT2 swissprot:TRAE1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRAE1_ECOLI Pfam PF05309 http://pfam.xfam.org/family/PF05309 Phobius swissprot:TRAE1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRAE1_ECOLI ProteinModelPortal P08322 http://www.proteinmodelportal.org/query/uniprot/P08322 PubMed 6090426 http://www.ncbi.nlm.nih.gov/pubmed/6090426 PubMed 7915817 http://www.ncbi.nlm.nih.gov/pubmed/7915817 RefSeq NP_061455 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061455 RefSeq WP_000399792 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000399792 TIGRFAMs TIGR02761 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02761 UniProtKB TRAE1_ECOLI http://www.uniprot.org/uniprot/TRAE1_ECOLI UniProtKB-AC P08322 http://www.uniprot.org/uniprot/P08322 charge swissprot:TRAE1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRAE1_ECOLI epestfind swissprot:TRAE1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRAE1_ECOLI garnier swissprot:TRAE1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRAE1_ECOLI helixturnhelix swissprot:TRAE1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRAE1_ECOLI hmoment swissprot:TRAE1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRAE1_ECOLI iep swissprot:TRAE1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRAE1_ECOLI inforesidue swissprot:TRAE1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRAE1_ECOLI octanol swissprot:TRAE1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRAE1_ECOLI pepcoil swissprot:TRAE1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRAE1_ECOLI pepdigest swissprot:TRAE1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRAE1_ECOLI pepinfo swissprot:TRAE1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRAE1_ECOLI pepnet swissprot:TRAE1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRAE1_ECOLI pepstats swissprot:TRAE1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRAE1_ECOLI pepwheel swissprot:TRAE1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRAE1_ECOLI pepwindow swissprot:TRAE1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRAE1_ECOLI sigcleave swissprot:TRAE1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRAE1_ECOLI ## Database ID URL or Descriptions # AltName GLGC_ECOLI ADP-glucose pyrophosphorylase # AltName GLGC_ECOLI ADP-glucose synthase # BRENDA 2.7.7.27 2026 # BioGrid 4262502 259 # CATALYTIC ACTIVITY GLGC_ECOLI ATP + alpha-D-glucose 1-phosphate = diphosphate + ADP-glucose. # ENZYME REGULATION GLGC_ECOLI Activated by fructose-1,6-bisphosphate and inhibited by AMP and ADP. Allosteric regulation. # EcoGene EG10379 glgC # FUNCTION GLGC_ECOLI Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0008878 glucose-1-phosphate adenylyltransferase activity; IDA:EcoCyc. # GO_function GO:0016208 AMP binding; IDA:EcoCyc. # GO_process GO:0005978 glycogen biosynthetic process; IMP:EcoCyc. # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.90.550.10 -; 2. # HAMAP MF_00624 GlgC # IntAct P0A6V1 6 # InterPro IPR005835 NTP_transferase_dom # InterPro IPR005836 ADP_Glu_pyroP_CS # InterPro IPR011004 Trimer_LpxA-like # InterPro IPR011831 GlgC # InterPro IPR023049 GlgC_bac # InterPro IPR029044 Nucleotide-diphossugar_trans # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00500 Starch and sucrose metabolism # KEGG_Pathway ko00520 Amino sugar and nucleotide sugar metabolism # Organism GLGC_ECOLI Escherichia coli (strain K12) # PATHWAY GLGC_ECOLI Glycan biosynthesis; glycogen biosynthesis. # PATRIC 32122300 VBIEscCol129921_3527 # PDB 5L6S X-ray; 3.04 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P=1-431 # PDB 5L6V X-ray; 2.67 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P=1-431 # PIR A00721 YUEC # PROSITE PS00808 ADP_GLC_PYROPHOSPH_1 # PROSITE PS00809 ADP_GLC_PYROPHOSPH_2 # PROSITE PS00810 ADP_GLC_PYROPHOSPH_3 # Pfam PF00483 NTP_transferase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLGC_ECOLI Glucose-1-phosphate adenylyltransferase # RefSeq NP_417888 NC_000913.3 # RefSeq WP_000253975 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. {ECO 0000305}. # SUBUNIT GLGC_ECOLI Homotetramer. # SUPFAM SSF51161 SSF51161 # SUPFAM SSF53448 SSF53448; 2 # TIGRFAMs TIGR02091 glgC # eggNOG COG0448 LUCA # eggNOG ENOG4107QQ4 Bacteria BLAST swissprot:GLGC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLGC_ECOLI BioCyc ECOL316407:JW3393-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3393-MONOMER BioCyc EcoCyc:GLUC1PADENYLTRANS-MONOMER http://biocyc.org/getid?id=EcoCyc:GLUC1PADENYLTRANS-MONOMER BioCyc MetaCyc:GLUC1PADENYLTRANS-MONOMER http://biocyc.org/getid?id=MetaCyc:GLUC1PADENYLTRANS-MONOMER COG COG0448 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0448 DIP DIP-48147N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48147N DOI 10.1006/abbi.1993.1181 http://dx.doi.org/10.1006/abbi.1993.1181 DOI 10.1016/0003-9861(92)90553-9 http://dx.doi.org/10.1016/0003-9861(92)90553-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.7.27 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.27 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01616 http://www.ebi.ac.uk/ena/data/view/J01616 EMBL M97226 http://www.ebi.ac.uk/ena/data/view/M97226 EMBL S58224 http://www.ebi.ac.uk/ena/data/view/S58224 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL V00281 http://www.ebi.ac.uk/ena/data/view/V00281 ENZYME 2.7.7.27 http://enzyme.expasy.org/EC/2.7.7.27 EchoBASE EB0374 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0374 EcoGene EG10379 http://www.ecogene.org/geneInfo.php?eg_id=EG10379 EnsemblBacteria AAC76455 http://www.ensemblgenomes.org/id/AAC76455 EnsemblBacteria AAC76455 http://www.ensemblgenomes.org/id/AAC76455 EnsemblBacteria BAE77862 http://www.ensemblgenomes.org/id/BAE77862 EnsemblBacteria BAE77862 http://www.ensemblgenomes.org/id/BAE77862 EnsemblBacteria BAE77862 http://www.ensemblgenomes.org/id/BAE77862 EnsemblBacteria b3430 http://www.ensemblgenomes.org/id/b3430 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008878 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008878 GO_function GO:0016208 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016208 GO_process GO:0005978 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005978 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.90.550.10 http://www.cathdb.info/version/latest/superfamily/3.90.550.10 GeneID 947942 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947942 HAMAP MF_00624 http://hamap.expasy.org/unirule/MF_00624 HOGENOM HOG000278607 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278607&db=HOGENOM6 InParanoid P0A6V1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6V1 IntAct P0A6V1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6V1* IntEnz 2.7.7.27 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.27 InterPro IPR005835 http://www.ebi.ac.uk/interpro/entry/IPR005835 InterPro IPR005836 http://www.ebi.ac.uk/interpro/entry/IPR005836 InterPro IPR011004 http://www.ebi.ac.uk/interpro/entry/IPR011004 InterPro IPR011831 http://www.ebi.ac.uk/interpro/entry/IPR011831 InterPro IPR023049 http://www.ebi.ac.uk/interpro/entry/IPR023049 InterPro IPR029044 http://www.ebi.ac.uk/interpro/entry/IPR029044 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3393 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3393 KEGG_Gene eco:b3430 http://www.genome.jp/dbget-bin/www_bget?eco:b3430 KEGG_Orthology KO:K00975 http://www.genome.jp/dbget-bin/www_bget?KO:K00975 KEGG_Pathway ko00500 http://www.genome.jp/kegg-bin/show_pathway?ko00500 KEGG_Pathway ko00520 http://www.genome.jp/kegg-bin/show_pathway?ko00520 KEGG_Reaction rn:R00948 http://www.genome.jp/dbget-bin/www_bget?rn:R00948 OMA FGCIDSD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FGCIDSD PDB 5L6S http://www.ebi.ac.uk/pdbe-srv/view/entry/5L6S PDB 5L6V http://www.ebi.ac.uk/pdbe-srv/view/entry/5L6V PDBsum 5L6S http://www.ebi.ac.uk/pdbsum/5L6S PDBsum 5L6V http://www.ebi.ac.uk/pdbsum/5L6V PROSITE PS00808 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00808 PROSITE PS00809 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00809 PROSITE PS00810 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00810 PSORT swissprot:GLGC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLGC_ECOLI PSORT-B swissprot:GLGC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLGC_ECOLI PSORT2 swissprot:GLGC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLGC_ECOLI Pfam PF00483 http://pfam.xfam.org/family/PF00483 Phobius swissprot:GLGC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLGC_ECOLI PhylomeDB P0A6V1 http://phylomedb.org/?seqid=P0A6V1 ProteinModelPortal P0A6V1 http://www.proteinmodelportal.org/query/uniprot/P0A6V1 PubMed 1320612 http://www.ncbi.nlm.nih.gov/pubmed/1320612 PubMed 1339262 http://www.ncbi.nlm.nih.gov/pubmed/1339262 PubMed 1648099 http://www.ncbi.nlm.nih.gov/pubmed/1648099 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2543670 http://www.ncbi.nlm.nih.gov/pubmed/2543670 PubMed 2844780 http://www.ncbi.nlm.nih.gov/pubmed/2844780 PubMed 359552 http://www.ncbi.nlm.nih.gov/pubmed/359552 PubMed 6300111 http://www.ncbi.nlm.nih.gov/pubmed/6300111 PubMed 8385906 http://www.ncbi.nlm.nih.gov/pubmed/8385906 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417888 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417888 RefSeq WP_000253975 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000253975 SMR P0A6V1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6V1 STRING 511145.b3430 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3430&targetmode=cogs STRING COG0448 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0448&targetmode=cogs SUPFAM SSF51161 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51161 SUPFAM SSF53448 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53448 TIGRFAMs TIGR02091 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02091 UniProtKB GLGC_ECOLI http://www.uniprot.org/uniprot/GLGC_ECOLI UniProtKB-AC P0A6V1 http://www.uniprot.org/uniprot/P0A6V1 charge swissprot:GLGC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLGC_ECOLI eggNOG COG0448 http://eggnogapi.embl.de/nog_data/html/tree/COG0448 eggNOG ENOG4107QQ4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QQ4 epestfind swissprot:GLGC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLGC_ECOLI garnier swissprot:GLGC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLGC_ECOLI helixturnhelix swissprot:GLGC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLGC_ECOLI hmoment swissprot:GLGC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLGC_ECOLI iep swissprot:GLGC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLGC_ECOLI inforesidue swissprot:GLGC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLGC_ECOLI octanol swissprot:GLGC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLGC_ECOLI pepcoil swissprot:GLGC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLGC_ECOLI pepdigest swissprot:GLGC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLGC_ECOLI pepinfo swissprot:GLGC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLGC_ECOLI pepnet swissprot:GLGC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLGC_ECOLI pepstats swissprot:GLGC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLGC_ECOLI pepwheel swissprot:GLGC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLGC_ECOLI pepwindow swissprot:GLGC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLGC_ECOLI sigcleave swissprot:GLGC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLGC_ECOLI ## Database ID URL or Descriptions # BioGrid 4262126 192 # CATALYTIC ACTIVITY Thiosulfate + cyanide = sulfite + thiocyanate. {ECO:0000269|PubMed 19798741}. # EcoGene EG14007 ynjE # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_function GO:0004792 thiosulfate sulfurtransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016783 sulfurtransferase activity; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # Gene3D 3.40.250.10 -; 3. # InterPro IPR001307 Thiosulphate_STrfase_CS # InterPro IPR001763 Rhodanese-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00270 Cysteine and methionine metabolism # KEGG_Pathway ko04122 Sulfur relay system # MISCELLANEOUS YNJE_ECOLI In vitro, YnjE can be efficiently persulfurated by the cysteine desulfurase IscS. # Organism YNJE_ECOLI Escherichia coli (strain K12) # PATRIC 32118825 VBIEscCol129921_1830 # PDB 2WLR X-ray; 1.45 A; A=24-435 # PDB 2WLX X-ray; 1.90 A; A=24-435 # PDB 3IPO X-ray; 2.40 A; A/B=20-435 # PDB 3IPP X-ray; 2.40 A; A/B=20-435 # PIR E64935 E64935 # PROSITE PS00380 RHODANESE_1 # PROSITE PS00683 RHODANESE_2 # PROSITE PS50206 RHODANESE_3; 3 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF00581 Rhodanese; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNJE_ECOLI Thiosulfate sulfurtransferase YnjE # RefSeq NP_416271 NC_000913.3 # RefSeq WP_001350515 NZ_LN832404.1 # SIMILARITY Contains 3 rhodanese domains. {ECO:0000255|PROSITE- ProRule PRU00173}. # SMART SM00450 RHOD; 3 # SUBCELLULAR LOCATION YNJE_ECOLI Periplasm {ECO 0000305}. # SUBUNIT Monomer. {ECO:0000305|PubMed 19798741}. # SUPFAM SSF52821 SSF52821; 3 # eggNOG COG2897 LUCA # eggNOG ENOG4107RM6 Bacteria BLAST swissprot:YNJE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNJE_ECOLI BioCyc ECOL316407:JW5287-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5287-MONOMER BioCyc EcoCyc:G6952-MONOMER http://biocyc.org/getid?id=EcoCyc:G6952-MONOMER BioCyc MetaCyc:G6952-MONOMER http://biocyc.org/getid?id=MetaCyc:G6952-MONOMER COG COG2897 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2897 DIP DIP-12782N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12782N DOI 10.1002/pro.260 http://dx.doi.org/10.1002/pro.260 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.8.1.1 http://www.genome.jp/dbget-bin/www_bget?EC:2.8.1.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.8.1.1 http://enzyme.expasy.org/EC/2.8.1.1 EchoBASE EB3763 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3763 EcoGene EG14007 http://www.ecogene.org/geneInfo.php?eg_id=EG14007 EnsemblBacteria AAC74827 http://www.ensemblgenomes.org/id/AAC74827 EnsemblBacteria AAC74827 http://www.ensemblgenomes.org/id/AAC74827 EnsemblBacteria BAA15548 http://www.ensemblgenomes.org/id/BAA15548 EnsemblBacteria BAA15548 http://www.ensemblgenomes.org/id/BAA15548 EnsemblBacteria BAA15548 http://www.ensemblgenomes.org/id/BAA15548 EnsemblBacteria b1757 http://www.ensemblgenomes.org/id/b1757 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0004792 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004792 GO_function GO:0016783 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016783 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 Gene3D 3.40.250.10 http://www.cathdb.info/version/latest/superfamily/3.40.250.10 GeneID 946505 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946505 HOGENOM HOG000282520 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000282520&db=HOGENOM6 InParanoid P78067 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P78067 IntEnz 2.8.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.8.1.1 InterPro IPR001307 http://www.ebi.ac.uk/interpro/entry/IPR001307 InterPro IPR001763 http://www.ebi.ac.uk/interpro/entry/IPR001763 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5287 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5287 KEGG_Gene eco:b1757 http://www.genome.jp/dbget-bin/www_bget?eco:b1757 KEGG_Orthology KO:K01011 http://www.genome.jp/dbget-bin/www_bget?KO:K01011 KEGG_Pathway ko00270 http://www.genome.jp/kegg-bin/show_pathway?ko00270 KEGG_Pathway ko04122 http://www.genome.jp/kegg-bin/show_pathway?ko04122 KEGG_Reaction rn:R01931 http://www.genome.jp/dbget-bin/www_bget?rn:R01931 KEGG_Reaction rn:R03105 http://www.genome.jp/dbget-bin/www_bget?rn:R03105 KEGG_Reaction rn:R03106 http://www.genome.jp/dbget-bin/www_bget?rn:R03106 OMA YMGVKDV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YMGVKDV PDB 2WLR http://www.ebi.ac.uk/pdbe-srv/view/entry/2WLR PDB 2WLX http://www.ebi.ac.uk/pdbe-srv/view/entry/2WLX PDB 3IPO http://www.ebi.ac.uk/pdbe-srv/view/entry/3IPO PDB 3IPP http://www.ebi.ac.uk/pdbe-srv/view/entry/3IPP PDBsum 2WLR http://www.ebi.ac.uk/pdbsum/2WLR PDBsum 2WLX http://www.ebi.ac.uk/pdbsum/2WLX PDBsum 3IPO http://www.ebi.ac.uk/pdbsum/3IPO PDBsum 3IPP http://www.ebi.ac.uk/pdbsum/3IPP PROSITE PS00380 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00380 PROSITE PS00683 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00683 PROSITE PS50206 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50206 PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YNJE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNJE_ECOLI PSORT-B swissprot:YNJE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNJE_ECOLI PSORT2 swissprot:YNJE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNJE_ECOLI Pfam PF00581 http://pfam.xfam.org/family/PF00581 Phobius swissprot:YNJE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNJE_ECOLI PhylomeDB P78067 http://phylomedb.org/?seqid=P78067 ProteinModelPortal P78067 http://www.proteinmodelportal.org/query/uniprot/P78067 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19798741 http://www.ncbi.nlm.nih.gov/pubmed/19798741 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416271 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416271 RefSeq WP_001350515 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001350515 SMART SM00450 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00450 SMR P78067 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P78067 STRING 511145.b1757 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1757&targetmode=cogs STRING COG2897 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2897&targetmode=cogs SUPFAM SSF52821 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52821 UniProtKB YNJE_ECOLI http://www.uniprot.org/uniprot/YNJE_ECOLI UniProtKB-AC P78067 http://www.uniprot.org/uniprot/P78067 charge swissprot:YNJE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNJE_ECOLI eggNOG COG2897 http://eggnogapi.embl.de/nog_data/html/tree/COG2897 eggNOG ENOG4107RM6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107RM6 epestfind swissprot:YNJE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNJE_ECOLI garnier swissprot:YNJE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNJE_ECOLI helixturnhelix swissprot:YNJE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNJE_ECOLI hmoment swissprot:YNJE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNJE_ECOLI iep swissprot:YNJE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNJE_ECOLI inforesidue swissprot:YNJE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNJE_ECOLI octanol swissprot:YNJE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNJE_ECOLI pepcoil swissprot:YNJE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNJE_ECOLI pepdigest swissprot:YNJE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNJE_ECOLI pepinfo swissprot:YNJE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNJE_ECOLI pepnet swissprot:YNJE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNJE_ECOLI pepstats swissprot:YNJE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNJE_ECOLI pepwheel swissprot:YNJE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNJE_ECOLI pepwindow swissprot:YNJE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNJE_ECOLI sigcleave swissprot:YNJE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNJE_ECOLI ## Database ID URL or Descriptions # BioGrid 4261805 243 # EcoGene EG13297 yaiO # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # InterPro IPR016504 UCP007027 # InterPro IPR030887 OMP_YaiO_dom # Organism YAIO_ECOLI Escherichia coli (strain K12) # PATRIC 32115855 VBIEscCol129921_0369 # PIR F64763 F64763 # PIRSF PIRSF007027 UCP007027 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAIO_ECOLI Uncharacterized protein YaiO # RefSeq NP_414892 NC_000913.3 # RefSeq WP_000596084 NZ_LN832404.1 # TCDB 9.B.52.1 the outer membrane protein yaio (yaio) family # TIGRFAMs TIGR04390 OMP_YaiO_dom # eggNOG ENOG4105SRB Bacteria # eggNOG ENOG4111YZU LUCA BLAST swissprot:YAIO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAIO_ECOLI BioCyc ECOL316407:JW0349-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0349-MONOMER BioCyc EcoCyc:G6210-MONOMER http://biocyc.org/getid?id=EcoCyc:G6210-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D85613 http://www.ebi.ac.uk/ena/data/view/D85613 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB3082 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3082 EcoGene EG13297 http://www.ecogene.org/geneInfo.php?eg_id=EG13297 EnsemblBacteria AAC73461 http://www.ensemblgenomes.org/id/AAC73461 EnsemblBacteria AAC73461 http://www.ensemblgenomes.org/id/AAC73461 EnsemblBacteria BAE76140 http://www.ensemblgenomes.org/id/BAE76140 EnsemblBacteria BAE76140 http://www.ensemblgenomes.org/id/BAE76140 EnsemblBacteria BAE76140 http://www.ensemblgenomes.org/id/BAE76140 EnsemblBacteria b0358 http://www.ensemblgenomes.org/id/b0358 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GeneID 945014 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945014 HOGENOM HOG000117412 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117412&db=HOGENOM6 InterPro IPR016504 http://www.ebi.ac.uk/interpro/entry/IPR016504 InterPro IPR030887 http://www.ebi.ac.uk/interpro/entry/IPR030887 KEGG_Gene ecj:JW0349 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0349 KEGG_Gene eco:b0358 http://www.genome.jp/dbget-bin/www_bget?eco:b0358 OMA NWLTTRM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NWLTTRM PSORT swissprot:YAIO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAIO_ECOLI PSORT-B swissprot:YAIO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAIO_ECOLI PSORT2 swissprot:YAIO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAIO_ECOLI Phobius swissprot:YAIO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAIO_ECOLI ProteinModelPortal Q47534 http://www.proteinmodelportal.org/query/uniprot/Q47534 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414892 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414892 RefSeq WP_000596084 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000596084 SMR Q47534 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q47534 STRING 511145.b0358 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0358&targetmode=cogs TCDB 9.B.52.1 http://www.tcdb.org/search/result.php?tc=9.B.52.1 TIGRFAMs TIGR04390 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR04390 UniProtKB YAIO_ECOLI http://www.uniprot.org/uniprot/YAIO_ECOLI UniProtKB-AC Q47534 http://www.uniprot.org/uniprot/Q47534 charge swissprot:YAIO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAIO_ECOLI eggNOG ENOG4105SRB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105SRB eggNOG ENOG4111YZU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111YZU epestfind swissprot:YAIO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAIO_ECOLI garnier swissprot:YAIO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAIO_ECOLI helixturnhelix swissprot:YAIO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAIO_ECOLI hmoment swissprot:YAIO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAIO_ECOLI iep swissprot:YAIO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAIO_ECOLI inforesidue swissprot:YAIO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAIO_ECOLI octanol swissprot:YAIO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAIO_ECOLI pepcoil swissprot:YAIO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAIO_ECOLI pepdigest swissprot:YAIO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAIO_ECOLI pepinfo swissprot:YAIO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAIO_ECOLI pepnet swissprot:YAIO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAIO_ECOLI pepstats swissprot:YAIO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAIO_ECOLI pepwheel swissprot:YAIO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAIO_ECOLI pepwindow swissprot:YAIO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAIO_ECOLI sigcleave swissprot:YAIO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAIO_ECOLI ## Database ID URL or Descriptions # BioGrid 4261270 7 # CDD cd06261 TM_PBP2 # EcoGene EG10002 modB # FUNCTION MODB_ECOLI Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015098 molybdate ion transmembrane transporter activity; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # Gene3D 1.10.3720.10 -; 1. # IntAct P0AF01 4 # InterPro IPR000515 MetI-like # InterPro IPR011867 ModB_ABC # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00189 Molybdate transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism MODB_ECOLI Escherichia coli (strain K12) # PATRIC 32116729 VBIEscCol129921_0790 # PIR D64812 BVECHJ # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MODB_ECOLI Molybdenum transport system permease protein ModB # RefSeq NP_415285 NC_000913.3 # RefSeq WP_000604034 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION MODB_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF161098 SSF161098 # TCDB 3.A.1.8 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR02141 modB_ABC # eggNOG COG4149 LUCA # eggNOG ENOG4105E0C Bacteria BLAST swissprot:MODB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MODB_ECOLI BioCyc ECOL316407:JW0747-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0747-MONOMER BioCyc EcoCyc:MODB-MONOMER http://biocyc.org/getid?id=EcoCyc:MODB-MONOMER BioCyc MetaCyc:MODB-MONOMER http://biocyc.org/getid?id=MetaCyc:MODB-MONOMER COG COG0555 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0555 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L34009 http://www.ebi.ac.uk/ena/data/view/L34009 EMBL M16182 http://www.ebi.ac.uk/ena/data/view/M16182 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U07867 http://www.ebi.ac.uk/ena/data/view/U07867 EMBL U27192 http://www.ebi.ac.uk/ena/data/view/U27192 EchoBASE EB0002 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0002 EcoGene EG10002 http://www.ecogene.org/geneInfo.php?eg_id=EG10002 EnsemblBacteria AAC73851 http://www.ensemblgenomes.org/id/AAC73851 EnsemblBacteria AAC73851 http://www.ensemblgenomes.org/id/AAC73851 EnsemblBacteria BAA35428 http://www.ensemblgenomes.org/id/BAA35428 EnsemblBacteria BAA35428 http://www.ensemblgenomes.org/id/BAA35428 EnsemblBacteria BAA35428 http://www.ensemblgenomes.org/id/BAA35428 EnsemblBacteria b0764 http://www.ensemblgenomes.org/id/b0764 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015098 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015098 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 945361 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945361 HOGENOM HOG000263699 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000263699&db=HOGENOM6 InParanoid P0AF01 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AF01 IntAct P0AF01 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AF01* InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 InterPro IPR011867 http://www.ebi.ac.uk/interpro/entry/IPR011867 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0747 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0747 KEGG_Gene eco:b0764 http://www.genome.jp/dbget-bin/www_bget?eco:b0764 KEGG_Orthology KO:K02018 http://www.genome.jp/dbget-bin/www_bget?KO:K02018 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA TPGAEME http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TPGAEME PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:MODB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MODB_ECOLI PSORT-B swissprot:MODB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MODB_ECOLI PSORT2 swissprot:MODB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MODB_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Phobius swissprot:MODB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MODB_ECOLI PhylomeDB P0AF01 http://phylomedb.org/?seqid=P0AF01 ProteinModelPortal P0AF01 http://www.proteinmodelportal.org/query/uniprot/P0AF01 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3553151 http://www.ncbi.nlm.nih.gov/pubmed/3553151 PubMed 7665460 http://www.ncbi.nlm.nih.gov/pubmed/7665460 PubMed 8564363 http://www.ncbi.nlm.nih.gov/pubmed/8564363 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415285 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415285 RefSeq WP_000604034 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000604034 SMR P0AF01 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AF01 STRING 511145.b0764 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0764&targetmode=cogs STRING COG0555 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0555&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.8 http://www.tcdb.org/search/result.php?tc=3.A.1.8 TIGRFAMs TIGR02141 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02141 UniProtKB MODB_ECOLI http://www.uniprot.org/uniprot/MODB_ECOLI UniProtKB-AC P0AF01 http://www.uniprot.org/uniprot/P0AF01 charge swissprot:MODB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MODB_ECOLI eggNOG COG4149 http://eggnogapi.embl.de/nog_data/html/tree/COG4149 eggNOG ENOG4105E0C http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E0C epestfind swissprot:MODB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MODB_ECOLI garnier swissprot:MODB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MODB_ECOLI helixturnhelix swissprot:MODB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MODB_ECOLI hmoment swissprot:MODB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MODB_ECOLI iep swissprot:MODB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MODB_ECOLI inforesidue swissprot:MODB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MODB_ECOLI octanol swissprot:MODB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MODB_ECOLI pepcoil swissprot:MODB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MODB_ECOLI pepdigest swissprot:MODB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MODB_ECOLI pepinfo swissprot:MODB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MODB_ECOLI pepnet swissprot:MODB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MODB_ECOLI pepstats swissprot:MODB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MODB_ECOLI pepwheel swissprot:MODB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MODB_ECOLI pepwindow swissprot:MODB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MODB_ECOLI sigcleave swissprot:MODB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MODB_ECOLI ## Database ID URL or Descriptions # BRENDA 4.2.3 2026 # BioGrid 4260938 3 # CATALYTIC ACTIVITY MGSA_ECOLI Glycerone phosphate = methylglyoxal + phosphate. # CDD cd01422 MGS # EcoGene EG12307 mgsA # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008929 methylglyoxal synthase activity; IDA:EcoCyc. # GO_process GO:0019242 methylglyoxal biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.1380 -; 1. # HAMAP MF_00549 Methylglyoxal_synth # InterPro IPR004363 Methylgl_synth # InterPro IPR011607 MGS-like_dom # InterPro IPR018148 Methylglyoxal_synth_AS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00620 Pyruvate metabolism # Organism MGSA_ECOLI Escherichia coli (strain K12) # PATRIC 32117145 VBIEscCol129921_0997 # PDB 1B93 X-ray; 1.90 A; A/B/C=1-152 # PDB 1EGH X-ray; 2.00 A; A/B/C/D/E/F=1-152 # PDB 1IK4 X-ray; 2.00 A; A/B/C/D/E/F=1-152 # PDB 1S89 X-ray; 2.22 A; A/B/C/D/E/F=1-152 # PDB 1S8A X-ray; 2.20 A; A/B/C/D/E/F=1-152 # PIR B64837 B64837 # PIRSF PIRSF006614 Methylglyox_syn # PROSITE PS01335 METHYLGLYOXAL_SYNTH # Pfam PF02142 MGS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MGSA_ECOLI Methylglyoxal synthase # RefSeq NP_415483 NC_000913.3 # RefSeq WP_000424181 NZ_LN832404.1 # SIMILARITY Belongs to the methylglyoxal synthase family. {ECO 0000305}. # SMART SM00851 MGS # SUBCELLULAR LOCATION MGSA_ECOLI Cytoplasm. # SUBUNIT MGSA_ECOLI Homohexamer. # SUPFAM SSF52335 SSF52335 # TIGRFAMs TIGR00160 MGSA # eggNOG COG1803 LUCA # eggNOG ENOG4108Z5K Bacteria BLAST swissprot:MGSA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MGSA_ECOLI BioCyc ECOL316407:JW5129-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5129-MONOMER BioCyc EcoCyc:METHGLYSYN-MONOMER http://biocyc.org/getid?id=EcoCyc:METHGLYSYN-MONOMER BioCyc MetaCyc:METHGLYSYN-MONOMER http://biocyc.org/getid?id=MetaCyc:METHGLYSYN-MONOMER COG COG1803 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1803 DIP DIP-48252N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48252N DOI 10.1016/S0969-2126(99)80041-0 http://dx.doi.org/10.1016/S0969-2126(99)80041-0 DOI 10.1021/bi980409p http://dx.doi.org/10.1021/bi980409p DOI 10.1021/bi992666f http://dx.doi.org/10.1021/bi992666f DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1998.00700.x http://dx.doi.org/10.1046/j.1365-2958.1998.00700.x DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.3.3 http://www.genome.jp/dbget-bin/www_bget?EC:4.2.3.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J04726 http://www.ebi.ac.uk/ena/data/view/J04726 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL Y11249 http://www.ebi.ac.uk/ena/data/view/Y11249 ENZYME 4.2.3.3 http://enzyme.expasy.org/EC/4.2.3.3 EchoBASE EB2213 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2213 EcoGene EG12307 http://www.ecogene.org/geneInfo.php?eg_id=EG12307 EnsemblBacteria AAC74049 http://www.ensemblgenomes.org/id/AAC74049 EnsemblBacteria AAC74049 http://www.ensemblgenomes.org/id/AAC74049 EnsemblBacteria BAA35728 http://www.ensemblgenomes.org/id/BAA35728 EnsemblBacteria BAA35728 http://www.ensemblgenomes.org/id/BAA35728 EnsemblBacteria BAA35728 http://www.ensemblgenomes.org/id/BAA35728 EnsemblBacteria b0963 http://www.ensemblgenomes.org/id/b0963 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008929 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008929 GO_process GO:0019242 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019242 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.1380 http://www.cathdb.info/version/latest/superfamily/3.40.50.1380 GeneID 945574 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945574 HAMAP MF_00549 http://hamap.expasy.org/unirule/MF_00549 HOGENOM HOG000283729 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000283729&db=HOGENOM6 InParanoid P0A731 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A731 IntEnz 4.2.3.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.3.3 InterPro IPR004363 http://www.ebi.ac.uk/interpro/entry/IPR004363 InterPro IPR011607 http://www.ebi.ac.uk/interpro/entry/IPR011607 InterPro IPR018148 http://www.ebi.ac.uk/interpro/entry/IPR018148 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5129 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5129 KEGG_Gene eco:b0963 http://www.genome.jp/dbget-bin/www_bget?eco:b0963 KEGG_Orthology KO:K01734 http://www.genome.jp/dbget-bin/www_bget?KO:K01734 KEGG_Pathway ko00620 http://www.genome.jp/kegg-bin/show_pathway?ko00620 KEGG_Reaction rn:R01016 http://www.genome.jp/dbget-bin/www_bget?rn:R01016 OMA MTPQPHE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MTPQPHE PDB 1B93 http://www.ebi.ac.uk/pdbe-srv/view/entry/1B93 PDB 1EGH http://www.ebi.ac.uk/pdbe-srv/view/entry/1EGH PDB 1IK4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1IK4 PDB 1S89 http://www.ebi.ac.uk/pdbe-srv/view/entry/1S89 PDB 1S8A http://www.ebi.ac.uk/pdbe-srv/view/entry/1S8A PDBsum 1B93 http://www.ebi.ac.uk/pdbsum/1B93 PDBsum 1EGH http://www.ebi.ac.uk/pdbsum/1EGH PDBsum 1IK4 http://www.ebi.ac.uk/pdbsum/1IK4 PDBsum 1S89 http://www.ebi.ac.uk/pdbsum/1S89 PDBsum 1S8A http://www.ebi.ac.uk/pdbsum/1S8A PROSITE PS01335 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01335 PSORT swissprot:MGSA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MGSA_ECOLI PSORT-B swissprot:MGSA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MGSA_ECOLI PSORT2 swissprot:MGSA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MGSA_ECOLI Pfam PF02142 http://pfam.xfam.org/family/PF02142 Phobius swissprot:MGSA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MGSA_ECOLI PhylomeDB P0A731 http://phylomedb.org/?seqid=P0A731 ProteinModelPortal P0A731 http://www.proteinmodelportal.org/query/uniprot/P0A731 PubMed 10368300 http://www.ncbi.nlm.nih.gov/pubmed/10368300 PubMed 10715115 http://www.ncbi.nlm.nih.gov/pubmed/10715115 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2542273 http://www.ncbi.nlm.nih.gov/pubmed/2542273 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9489667 http://www.ncbi.nlm.nih.gov/pubmed/9489667 PubMed 9665712 http://www.ncbi.nlm.nih.gov/pubmed/9665712 RefSeq NP_415483 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415483 RefSeq WP_000424181 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000424181 SMART SM00851 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00851 SMR P0A731 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A731 STRING 511145.b0963 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0963&targetmode=cogs STRING COG1803 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1803&targetmode=cogs SUPFAM SSF52335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52335 TIGRFAMs TIGR00160 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00160 UniProtKB MGSA_ECOLI http://www.uniprot.org/uniprot/MGSA_ECOLI UniProtKB-AC P0A731 http://www.uniprot.org/uniprot/P0A731 charge swissprot:MGSA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MGSA_ECOLI eggNOG COG1803 http://eggnogapi.embl.de/nog_data/html/tree/COG1803 eggNOG ENOG4108Z5K http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Z5K epestfind swissprot:MGSA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MGSA_ECOLI garnier swissprot:MGSA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MGSA_ECOLI helixturnhelix swissprot:MGSA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MGSA_ECOLI hmoment swissprot:MGSA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MGSA_ECOLI iep swissprot:MGSA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MGSA_ECOLI inforesidue swissprot:MGSA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MGSA_ECOLI octanol swissprot:MGSA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MGSA_ECOLI pepcoil swissprot:MGSA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MGSA_ECOLI pepdigest swissprot:MGSA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MGSA_ECOLI pepinfo swissprot:MGSA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MGSA_ECOLI pepnet swissprot:MGSA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MGSA_ECOLI pepstats swissprot:MGSA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MGSA_ECOLI pepwheel swissprot:MGSA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MGSA_ECOLI pepwindow swissprot:MGSA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MGSA_ECOLI sigcleave swissprot:MGSA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MGSA_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES BETB_ECOLI Kinetic parameters KM=99 uM for NAD (at pH 7.5 and 25 degrees Celsius) {ECO 0000269|PubMed 2194570, ECO 0000269|PubMed 3512525}; KM=160 uM for betaine aldehyde (at pH 7.5 and 25 degrees Celsius) {ECO 0000269|PubMed 2194570, ECO 0000269|PubMed 3512525}; KM=400 uM for NADP (at pH 7.5 and 25 degrees Celsius) {ECO 0000269|PubMed 2194570, ECO 0000269|PubMed 3512525}; Vmax=66 umol/min/mg enzyme (at pH 7.5 and 25 degrees Celsius) {ECO 0000269|PubMed 2194570, ECO 0000269|PubMed 3512525}; pH dependence Optimum pH is between 7.5 and 9.5. {ECO 0000269|PubMed 2194570, ECO 0000269|PubMed 3512525}; # BioGrid 4262801 3 # CATALYTIC ACTIVITY BETB_ECOLI Betaine aldehyde + NAD(+) + H(2)O = betaine + NADH. {ECO 0000255|HAMAP-Rule MF_00804, ECO 0000269|PubMed 2194570, ECO 0000269|PubMed 3512525}. # COFACTOR BETB_ECOLI Name=K(+); Xref=ChEBI CHEBI 29103; Evidence={ECO 0000255|HAMAP-Rule MF_00804}; Note=Binds 2 potassium ions per subunit. {ECO 0000255|HAMAP- Rule MF_00804}; # ENZYME REGULATION Aldehydes with apolar groups are the most effective inhibitors. N-Methylated compounds are also inhibitory, but to a much lesser degree than the aldehydes. The alcohols are more inhibitory than the corresponding acids, and the inhibitory effect increases with the degree of methylation from ethanolamine to choline. {ECO:0000269|PubMed 2194570}. # EcoGene EG10110 betB # FUNCTION BETB_ECOLI Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid. It is highly specific for betaine and has a significantly higher affinity for NAD than for NADP. {ECO 0000255|HAMAP-Rule MF_00804, ECO 0000269|PubMed 2194570, ECO 0000269|PubMed 3512525}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008802 betaine-aldehyde dehydrogenase activity; IDA:EcoCyc. # GO_function GO:0019145 aminobutyraldehyde dehydrogenase activity; IBA:GO_Central. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0047105 4-trimethylammoniobutyraldehyde dehydrogenase activity; IBA:GO_Central. # GO_process GO:0006970 response to osmotic stress; IEP:EcoCyc. # GO_process GO:0019285 glycine betaine biosynthetic process from choline; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.309.10 -; 1. # Gene3D 3.40.605.10 -; 1. # HAMAP MF_00804 BADH # INDUCTION BETB_ECOLI By osmotic stress. Choline is required for full expression. Oxygen and choline exert their control via the transacting DNA-binding proteins ArcA and BetI, respectively. {ECO 0000269|PubMed 3512525, ECO 0000269|PubMed 8626294}. # IntAct P17445 7 # InterPro IPR011264 BADH # InterPro IPR015590 Aldehyde_DH_dom # InterPro IPR016160 Ald_DH_CS_CYS # InterPro IPR016161 Ald_DH/histidinol_DH # InterPro IPR016162 Ald_DH_N # InterPro IPR016163 Ald_DH_C # InterPro IPR029510 Ald_DH_CS_GLU # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00260 Glycine, serine and threonine metabolism # Organism BETB_ECOLI Escherichia coli (strain K12) # PATHWAY Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. {ECO 0000255|HAMAP-Rule:MF_00804}. # PATRIC 32115753 VBIEscCol129921_0319 # PIR S15181 S15181 # PROSITE PS00070 ALDEHYDE_DEHYDR_CYS # PROSITE PS00687 ALDEHYDE_DEHYDR_GLU # Pfam PF00171 Aldedh # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NAD/NADP-dependent betaine aldehyde dehydrogenase {ECO:0000255|HAMAP-Rule MF_00804} # RefSeq NP_414846 NC_000913.3 # RefSeq WP_000089110 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA23505.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAB18038.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the aldehyde dehydrogenase family. {ECO:0000255|HAMAP-Rule MF_00804}. # SUBUNIT Dimer of dimers. {ECO:0000305|PubMed 2194570}. # SUPFAM SSF53720 SSF53720 # TIGRFAMs TIGR01804 BADH # UniPathway UPA00529 UER00386 # eggNOG COG1012 LUCA # eggNOG ENOG4105C26 Bacteria BLAST swissprot:BETB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BETB_ECOLI BioCyc ECOL316407:JW0304-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0304-MONOMER BioCyc EcoCyc:BADH-MONOMER http://biocyc.org/getid?id=EcoCyc:BADH-MONOMER BioCyc MetaCyc:BADH-MONOMER http://biocyc.org/getid?id=MetaCyc:BADH-MONOMER COG COG1012 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1012 DIP DIP-9208N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9208N DOI 10.1016/0304-4165(90)90046-Y http://dx.doi.org/10.1016/0304-4165(90)90046-Y DOI 10.1016/0378-1119(91)90389-S http://dx.doi.org/10.1016/0378-1119(91)90389-S DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1991.tb01877.x http://dx.doi.org/10.1111/j.1365-2958.1991.tb01877.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.2.1.8 {ECO:0000255|HAMAP-Rule:MF_00804} http://www.genome.jp/dbget-bin/www_bget?EC:1.2.1.8 {ECO:0000255|HAMAP-Rule:MF_00804} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M77739 http://www.ebi.ac.uk/ena/data/view/M77739 EMBL M77739 http://www.ebi.ac.uk/ena/data/view/M77739 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EMBL X52905 http://www.ebi.ac.uk/ena/data/view/X52905 ENZYME 1.2.1.8 {ECO:0000255|HAMAP-Rule:MF_00804} http://enzyme.expasy.org/EC/1.2.1.8 {ECO:0000255|HAMAP-Rule:MF_00804} EchoBASE EB0108 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0108 EcoGene EG10110 http://www.ecogene.org/geneInfo.php?eg_id=EG10110 EnsemblBacteria AAC73415 http://www.ensemblgenomes.org/id/AAC73415 EnsemblBacteria AAC73415 http://www.ensemblgenomes.org/id/AAC73415 EnsemblBacteria BAE76095 http://www.ensemblgenomes.org/id/BAE76095 EnsemblBacteria BAE76095 http://www.ensemblgenomes.org/id/BAE76095 EnsemblBacteria BAE76095 http://www.ensemblgenomes.org/id/BAE76095 EnsemblBacteria b0312 http://www.ensemblgenomes.org/id/b0312 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008802 GO_function GO:0019145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019145 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0047105 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047105 GO_process GO:0006970 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006970 GO_process GO:0019285 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019285 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.309.10 http://www.cathdb.info/version/latest/superfamily/3.40.309.10 Gene3D 3.40.605.10 http://www.cathdb.info/version/latest/superfamily/3.40.605.10 GeneID 947376 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947376 HAMAP MF_00804 http://hamap.expasy.org/unirule/MF_00804 HOGENOM HOG000271505 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000271505&db=HOGENOM6 InParanoid P17445 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P17445 IntAct P17445 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P17445* IntEnz 1.2.1.8 {ECO:0000255|HAMAP-Rule:MF_00804} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.2.1.8 {ECO:0000255|HAMAP-Rule:MF_00804} InterPro IPR011264 http://www.ebi.ac.uk/interpro/entry/IPR011264 InterPro IPR015590 http://www.ebi.ac.uk/interpro/entry/IPR015590 InterPro IPR016160 http://www.ebi.ac.uk/interpro/entry/IPR016160 InterPro IPR016161 http://www.ebi.ac.uk/interpro/entry/IPR016161 InterPro IPR016162 http://www.ebi.ac.uk/interpro/entry/IPR016162 InterPro IPR016163 http://www.ebi.ac.uk/interpro/entry/IPR016163 InterPro IPR029510 http://www.ebi.ac.uk/interpro/entry/IPR029510 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0304 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0304 KEGG_Gene eco:b0312 http://www.genome.jp/dbget-bin/www_bget?eco:b0312 KEGG_Orthology KO:K00130 http://www.genome.jp/dbget-bin/www_bget?KO:K00130 KEGG_Pathway ko00260 http://www.genome.jp/kegg-bin/show_pathway?ko00260 KEGG_Reaction rn:R02565 http://www.genome.jp/dbget-bin/www_bget?rn:R02565 KEGG_Reaction rn:R02566 http://www.genome.jp/dbget-bin/www_bget?rn:R02566 OMA TKSVYVG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TKSVYVG PROSITE PS00070 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00070 PROSITE PS00687 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00687 PSORT swissprot:BETB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BETB_ECOLI PSORT-B swissprot:BETB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BETB_ECOLI PSORT2 swissprot:BETB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BETB_ECOLI Pfam PF00171 http://pfam.xfam.org/family/PF00171 Phobius swissprot:BETB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BETB_ECOLI PhylomeDB P17445 http://phylomedb.org/?seqid=P17445 ProteinModelPortal P17445 http://www.proteinmodelportal.org/query/uniprot/P17445 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1879697 http://www.ncbi.nlm.nih.gov/pubmed/1879697 PubMed 1956285 http://www.ncbi.nlm.nih.gov/pubmed/1956285 PubMed 2194570 http://www.ncbi.nlm.nih.gov/pubmed/2194570 PubMed 3512525 http://www.ncbi.nlm.nih.gov/pubmed/3512525 PubMed 8626294 http://www.ncbi.nlm.nih.gov/pubmed/8626294 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414846 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414846 RefSeq WP_000089110 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000089110 SMR P17445 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P17445 STRING 511145.b0312 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0312&targetmode=cogs STRING COG1012 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1012&targetmode=cogs SUPFAM SSF53720 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53720 TIGRFAMs TIGR01804 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01804 UniProtKB BETB_ECOLI http://www.uniprot.org/uniprot/BETB_ECOLI UniProtKB-AC P17445 http://www.uniprot.org/uniprot/P17445 charge swissprot:BETB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BETB_ECOLI eggNOG COG1012 http://eggnogapi.embl.de/nog_data/html/tree/COG1012 eggNOG ENOG4105C26 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C26 epestfind swissprot:BETB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BETB_ECOLI garnier swissprot:BETB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BETB_ECOLI helixturnhelix swissprot:BETB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BETB_ECOLI hmoment swissprot:BETB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BETB_ECOLI iep swissprot:BETB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BETB_ECOLI inforesidue swissprot:BETB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BETB_ECOLI octanol swissprot:BETB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BETB_ECOLI pepcoil swissprot:BETB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BETB_ECOLI pepdigest swissprot:BETB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BETB_ECOLI pepinfo swissprot:BETB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BETB_ECOLI pepnet swissprot:BETB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BETB_ECOLI pepstats swissprot:BETB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BETB_ECOLI pepwheel swissprot:BETB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BETB_ECOLI pepwindow swissprot:BETB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BETB_ECOLI sigcleave swissprot:BETB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BETB_ECOLI ## Database ID URL or Descriptions # AltName DACA_ECOLI Beta-lactamase # AltName DACA_ECOLI Penicillin-binding protein 5 # BRENDA 3.4.16 2026 # BioGrid 4260698 250 # CATALYTIC ACTIVITY DACA_ECOLI A beta-lactam + H(2)O = a substituted beta- amino acid. # CATALYTIC ACTIVITY Preferential cleavage (Ac)(2)-L-Lys-D-Ala-|- D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine. # DrugBank DB00274 Cefmetazole # DrugBank DB01329 Cefoperazone # DrugBank DB01331 Cefoxitin # EcoGene EG10201 dacA # FUNCTION DACA_ECOLI Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoliWiki. # GO_function GO:0004175 endopeptidase activity; IBA:GO_Central. # GO_function GO:0004180 carboxypeptidase activity; IDA:EcoCyc. # GO_function GO:0008658 penicillin binding; IDA:EcoCyc. # GO_function GO:0008800 beta-lactamase activity; IEA:UniProtKB-EC. # GO_function GO:0009002 serine-type D-Ala-D-Ala carboxypeptidase activity; IDA:CACAO. # GO_process GO:0000270 peptidoglycan metabolic process; IDA:EcoCyc. # GO_process GO:0008360 regulation of cell shape; IGI:EcoCyc. # GO_process GO:0009252 peptidoglycan biosynthetic process; IBA:GO_Central. # GO_process GO:0044036 cell wall macromolecule metabolic process; IDA:EcoCyc. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 2.60.410.10 -; 1. # Gene3D 3.40.710.10 -; 1. # IntAct P0AEB2 8 # InterPro IPR001967 Peptidase_S11_N # InterPro IPR012338 Beta-lactam/transpept-like # InterPro IPR012907 Peptidase_S11_C # InterPro IPR015956 Peniciliin-bd_prot-assoc # InterPro IPR018044 Peptidase_S11 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # KEGG_Pathway ko00550 Peptidoglycan biosynthesis # Organism DACA_ECOLI Escherichia coli (strain K12) # PATHWAY DACA_ECOLI Cell wall biogenesis; peptidoglycan biosynthesis. # PATRIC 32116445 VBIEscCol129921_0662 # PDB 1HD8 X-ray; 2.30 A; A=30-386 # PDB 1NJ4 X-ray; 1.90 A; A=30-392 # PDB 1NZO X-ray; 1.85 A; A=30-392 # PDB 1NZU X-ray; 2.00 A; A=30-392 # PDB 1SDN X-ray; 2.50 A; A=30-392 # PDB 1Z6F X-ray; 1.60 A; A=30-392 # PDB 3BEB X-ray; 2.00 A; A=30-386 # PDB 3BEC X-ray; 1.60 A; A=30-386 # PDB 3MZD X-ray; 1.90 A; A=30-386 # PDB 3MZE X-ray; 2.10 A; A=30-386 # PDB 3MZF X-ray; 1.50 A; A=30-386 # PDB 5J8X X-ray; 2.53 A; A=30-392 # PIR A28536 ZPECP5 # PRINTS PR00725 DADACBPTASE1 # Pfam PF00768 Peptidase_S11 # Pfam PF07943 PBP5_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DACA_ECOLI D-alanyl-D-alanine carboxypeptidase DacA # RefSeq NP_415165 NC_000913.3 # RefSeq WP_001092082 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40832.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the peptidase S11 family. {ECO 0000305}. # SMART SM00936 PBP5_C # SUBCELLULAR LOCATION DACA_ECOLI Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=N-terminal lies in the periplasmic space. # SUPFAM SSF56601 SSF56601 # SUPFAM SSF69189 SSF69189 # eggNOG COG1686 LUCA # eggNOG ENOG4105DZ1 Bacteria BLAST swissprot:DACA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DACA_ECOLI BioCyc ECOL316407:JW0627-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0627-MONOMER BioCyc EcoCyc:EG10201-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10201-MONOMER BioCyc MetaCyc:EG10201-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10201-MONOMER COG COG1686 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1686 DIP DIP-47947N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47947N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0014-5793(82)80840-5 http://dx.doi.org/10.1016/0014-5793(82)80840-5 DOI 10.1016/0014-5793(84)80166-0 http://dx.doi.org/10.1016/0014-5793(84)80166-0 DOI 10.1021/bi0473004 http://dx.doi.org/10.1021/bi0473004 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M004471200 http://dx.doi.org/10.1074/jbc.M004471200 DOI 10.1074/jbc.M310177200 http://dx.doi.org/10.1074/jbc.M310177200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/16.4.1617 http://dx.doi.org/10.1093/nar/16.4.1617 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB00274 http://www.drugbank.ca/drugs/DB00274 DrugBank DB01329 http://www.drugbank.ca/drugs/DB01329 DrugBank DB01331 http://www.drugbank.ca/drugs/DB01331 EC_number EC:3.4.16.4 http://www.genome.jp/dbget-bin/www_bget?EC:3.4.16.4 EC_number EC:3.5.2.6 http://www.genome.jp/dbget-bin/www_bget?EC:3.5.2.6 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L07636 http://www.ebi.ac.uk/ena/data/view/L07636 EMBL M18276 http://www.ebi.ac.uk/ena/data/view/M18276 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EMBL X06479 http://www.ebi.ac.uk/ena/data/view/X06479 ENZYME 3.4.16.4 http://enzyme.expasy.org/EC/3.4.16.4 ENZYME 3.5.2.6 http://enzyme.expasy.org/EC/3.5.2.6 EchoBASE EB0197 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0197 EcoGene EG10201 http://www.ecogene.org/geneInfo.php?eg_id=EG10201 EnsemblBacteria AAC73733 http://www.ensemblgenomes.org/id/AAC73733 EnsemblBacteria AAC73733 http://www.ensemblgenomes.org/id/AAC73733 EnsemblBacteria BAA35275 http://www.ensemblgenomes.org/id/BAA35275 EnsemblBacteria BAA35275 http://www.ensemblgenomes.org/id/BAA35275 EnsemblBacteria BAA35275 http://www.ensemblgenomes.org/id/BAA35275 EnsemblBacteria b0632 http://www.ensemblgenomes.org/id/b0632 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0004175 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004175 GO_function GO:0004180 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004180 GO_function GO:0008658 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008658 GO_function GO:0008800 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008800 GO_function GO:0009002 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009002 GO_process GO:0000270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000270 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0009252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009252 GO_process GO:0044036 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044036 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 2.60.410.10 http://www.cathdb.info/version/latest/superfamily/2.60.410.10 Gene3D 3.40.710.10 http://www.cathdb.info/version/latest/superfamily/3.40.710.10 GeneID 945222 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945222 HOGENOM HOG000086623 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000086623&db=HOGENOM6 InParanoid P0AEB2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEB2 IntAct P0AEB2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEB2* IntEnz 3.4.16.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.16.4 IntEnz 3.5.2.6 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.2.6 InterPro IPR001967 http://www.ebi.ac.uk/interpro/entry/IPR001967 InterPro IPR012338 http://www.ebi.ac.uk/interpro/entry/IPR012338 InterPro IPR012907 http://www.ebi.ac.uk/interpro/entry/IPR012907 InterPro IPR015956 http://www.ebi.ac.uk/interpro/entry/IPR015956 InterPro IPR018044 http://www.ebi.ac.uk/interpro/entry/IPR018044 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW0627 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0627 KEGG_Gene eco:b0632 http://www.genome.jp/dbget-bin/www_bget?eco:b0632 KEGG_Orthology KO:K07258 http://www.genome.jp/dbget-bin/www_bget?KO:K07258 KEGG_Pathway ko00550 http://www.genome.jp/kegg-bin/show_pathway?ko00550 MINT MINT-1247273 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1247273 OMA GKIHQDD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GKIHQDD PDB 1HD8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1HD8 PDB 1NJ4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1NJ4 PDB 1NZO http://www.ebi.ac.uk/pdbe-srv/view/entry/1NZO PDB 1NZU http://www.ebi.ac.uk/pdbe-srv/view/entry/1NZU PDB 1SDN http://www.ebi.ac.uk/pdbe-srv/view/entry/1SDN PDB 1Z6F http://www.ebi.ac.uk/pdbe-srv/view/entry/1Z6F PDB 3BEB http://www.ebi.ac.uk/pdbe-srv/view/entry/3BEB PDB 3BEC http://www.ebi.ac.uk/pdbe-srv/view/entry/3BEC PDB 3MZD http://www.ebi.ac.uk/pdbe-srv/view/entry/3MZD PDB 3MZE http://www.ebi.ac.uk/pdbe-srv/view/entry/3MZE PDB 3MZF http://www.ebi.ac.uk/pdbe-srv/view/entry/3MZF PDB 5J8X http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8X PDBsum 1HD8 http://www.ebi.ac.uk/pdbsum/1HD8 PDBsum 1NJ4 http://www.ebi.ac.uk/pdbsum/1NJ4 PDBsum 1NZO http://www.ebi.ac.uk/pdbsum/1NZO PDBsum 1NZU http://www.ebi.ac.uk/pdbsum/1NZU PDBsum 1SDN http://www.ebi.ac.uk/pdbsum/1SDN PDBsum 1Z6F http://www.ebi.ac.uk/pdbsum/1Z6F PDBsum 3BEB http://www.ebi.ac.uk/pdbsum/3BEB PDBsum 3BEC http://www.ebi.ac.uk/pdbsum/3BEC PDBsum 3MZD http://www.ebi.ac.uk/pdbsum/3MZD PDBsum 3MZE http://www.ebi.ac.uk/pdbsum/3MZE PDBsum 3MZF http://www.ebi.ac.uk/pdbsum/3MZF PDBsum 5J8X http://www.ebi.ac.uk/pdbsum/5J8X PRINTS PR00725 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00725 PSORT swissprot:DACA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DACA_ECOLI PSORT-B swissprot:DACA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DACA_ECOLI PSORT2 swissprot:DACA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DACA_ECOLI Pfam PF00768 http://pfam.xfam.org/family/PF00768 Pfam PF07943 http://pfam.xfam.org/family/PF07943 Phobius swissprot:DACA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DACA_ECOLI PhylomeDB P0AEB2 http://phylomedb.org/?seqid=P0AEB2 ProteinModelPortal P0AEB2 http://www.proteinmodelportal.org/query/uniprot/P0AEB2 PubMed 10967102 http://www.ncbi.nlm.nih.gov/pubmed/10967102 PubMed 14555648 http://www.ncbi.nlm.nih.gov/pubmed/14555648 PubMed 15938610 http://www.ncbi.nlm.nih.gov/pubmed/15938610 PubMed 1597468 http://www.ncbi.nlm.nih.gov/pubmed/1597468 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3279397 http://www.ncbi.nlm.nih.gov/pubmed/3279397 PubMed 3316191 http://www.ncbi.nlm.nih.gov/pubmed/3316191 PubMed 6319180 http://www.ncbi.nlm.nih.gov/pubmed/6319180 PubMed 7042389 http://www.ncbi.nlm.nih.gov/pubmed/7042389 PubMed 8424800 http://www.ncbi.nlm.nih.gov/pubmed/8424800 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_415165 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415165 RefSeq WP_001092082 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001092082 SMART SM00936 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00936 SMR P0AEB2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEB2 STRING 511145.b0632 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0632&targetmode=cogs STRING COG1686 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1686&targetmode=cogs SUPFAM SSF56601 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56601 SUPFAM SSF69189 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF69189 UniProtKB DACA_ECOLI http://www.uniprot.org/uniprot/DACA_ECOLI UniProtKB-AC P0AEB2 http://www.uniprot.org/uniprot/P0AEB2 charge swissprot:DACA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DACA_ECOLI eggNOG COG1686 http://eggnogapi.embl.de/nog_data/html/tree/COG1686 eggNOG ENOG4105DZ1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DZ1 epestfind swissprot:DACA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DACA_ECOLI garnier swissprot:DACA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DACA_ECOLI helixturnhelix swissprot:DACA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DACA_ECOLI hmoment swissprot:DACA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DACA_ECOLI iep swissprot:DACA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DACA_ECOLI inforesidue swissprot:DACA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DACA_ECOLI octanol swissprot:DACA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DACA_ECOLI pepcoil swissprot:DACA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DACA_ECOLI pepdigest swissprot:DACA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DACA_ECOLI pepinfo swissprot:DACA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DACA_ECOLI pepnet swissprot:DACA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DACA_ECOLI pepstats swissprot:DACA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DACA_ECOLI pepwheel swissprot:DACA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DACA_ECOLI pepwindow swissprot:DACA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DACA_ECOLI sigcleave swissprot:DACA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DACA_ECOLI ## Database ID URL or Descriptions # AltName 3PASE_ECOLI ORFXE # BIOPHYSICOCHEMICAL PROPERTIES 3PASE_ECOLI Kinetic parameters KM=270 uM for inorganic triphosphate {ECO 0000269|PubMed 22984449}; Vmax=27 umol/min/mg enzyme {ECO 0000269|PubMed 22984449}; pH dependence Optimum pH is 8.5. {ECO 0000269|PubMed 22984449}; # BioGrid 4259253 4 # CATALYTIC ACTIVITY Triphosphate + H(2)O = diphosphate + phosphate. {ECO:0000269|PubMed 22984449}. # DISRUPTION PHENOTYPE Cells lacking this gene do not show decrease of specific PPPase activity. {ECO:0000269|PubMed 22984449}. # ENZYME REGULATION Inhibited by calcium ion and activated by magnesium ion. {ECO:0000269|PubMed 22984449}. # EcoGene EG11603 ygiF # FUNCTION 3PASE_ECOLI Involved in the hydrolysis of the beta-gamma- phosphoanhydride linkage of triphosphate-containing substrates (inorganic or nucleoside-linked). Catalyzes the hydrolysis of inorganic triphosphate (PPPi), which could be cytotoxic because of its high affinity for calcium ion, thereby interfering with calcium signaling. It also hydrolyzes slowly thiamine triphosphate (ThTP). YgiF is a specific PPPase, but it contributes only marginally to the total PPPase activity in E.coli, where the main enzyme responsible for hydrolysis of PPPi is inorganic pyrophosphatase (PPase). {ECO 0000269|PubMed 22984449}. # GO_function GO:0046872 metal ion binding; IDA:EcoCyc. # GO_function GO:0050355 triphosphatase activity; IDA:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # Gene3D 2.40.320.10 -; 1. # IntAct P30871 23 # InterPro IPR007899 CHAD_dom # InterPro IPR023577 CYTH_domain # InterPro IPR033469 CYTH-like_dom # Organism 3PASE_ECOLI Escherichia coli (strain K12) # PATRIC 32121520 VBIEscCol129921_3147 # PDB 5A60 X-ray; 1.82 A; A=1-433 # PDB 5A61 X-ray; 1.50 A; A=1-433 # PIR S37754 S37754 # PROSITE PS51707 CYTH # PROSITE PS51708 CHAD # Pfam PF01928 CYTH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 3PASE_ECOLI Inorganic triphosphatase # RefSeq NP_417526 NC_000913.3 # RefSeq WP_000046281 NZ_LN832404.1 # SIMILARITY Contains 1 CHAD domain. {ECO:0000255|PROSITE- ProRule PRU01045}. # SIMILARITY Contains 1 CYTH domain. {ECO:0000255|PROSITE- ProRule PRU01044}. # SMART SM01118 CYTH # SUPFAM SSF55154 SSF55154 # eggNOG COG3025 LUCA # eggNOG ENOG4105I7R Bacteria BLAST swissprot:3PASE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:3PASE_ECOLI BioCyc ECOL316407:JW3026-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3026-MONOMER BioCyc EcoCyc:EG11603-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11603-MONOMER BioCyc MetaCyc:EG11603-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11603-MONOMER DIP DIP-12218N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12218N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1993.tb01706.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb01706.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pone.0043879 http://dx.doi.org/10.1371/journal.pone.0043879 EC_number EC:3.6.1.25 http://www.genome.jp/dbget-bin/www_bget?EC:3.6.1.25 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL Z21844 http://www.ebi.ac.uk/ena/data/view/Z21844 ENZYME 3.6.1.25 http://enzyme.expasy.org/EC/3.6.1.25 EchoBASE EB1560 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1560 EcoGene EG11603 http://www.ecogene.org/geneInfo.php?eg_id=EG11603 EnsemblBacteria AAC76090 http://www.ensemblgenomes.org/id/AAC76090 EnsemblBacteria AAC76090 http://www.ensemblgenomes.org/id/AAC76090 EnsemblBacteria BAE77105 http://www.ensemblgenomes.org/id/BAE77105 EnsemblBacteria BAE77105 http://www.ensemblgenomes.org/id/BAE77105 EnsemblBacteria BAE77105 http://www.ensemblgenomes.org/id/BAE77105 EnsemblBacteria b3054 http://www.ensemblgenomes.org/id/b3054 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0050355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050355 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 2.40.320.10 http://www.cathdb.info/version/latest/superfamily/2.40.320.10 GeneID 947554 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947554 HOGENOM HOG000283528 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000283528&db=HOGENOM6 InParanoid P30871 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30871 IntAct P30871 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P30871* IntEnz 3.6.1.25 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.1.25 InterPro IPR007899 http://www.ebi.ac.uk/interpro/entry/IPR007899 InterPro IPR023577 http://www.ebi.ac.uk/interpro/entry/IPR023577 InterPro IPR033469 http://www.ebi.ac.uk/interpro/entry/IPR033469 KEGG_Gene ecj:JW3026 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3026 KEGG_Gene eco:b3054 http://www.genome.jp/dbget-bin/www_bget?eco:b3054 MINT MINT-1248396 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1248396 OMA QEPICEL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QEPICEL PDB 5A60 http://www.ebi.ac.uk/pdbe-srv/view/entry/5A60 PDB 5A61 http://www.ebi.ac.uk/pdbe-srv/view/entry/5A61 PDBsum 5A60 http://www.ebi.ac.uk/pdbsum/5A60 PDBsum 5A61 http://www.ebi.ac.uk/pdbsum/5A61 PROSITE PS51707 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51707 PROSITE PS51708 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51708 PSORT swissprot:3PASE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:3PASE_ECOLI PSORT-B swissprot:3PASE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:3PASE_ECOLI PSORT2 swissprot:3PASE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:3PASE_ECOLI Pfam PF01928 http://pfam.xfam.org/family/PF01928 Phobius swissprot:3PASE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:3PASE_ECOLI ProteinModelPortal P30871 http://www.proteinmodelportal.org/query/uniprot/P30871 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22984449 http://www.ncbi.nlm.nih.gov/pubmed/22984449 PubMed 8412694 http://www.ncbi.nlm.nih.gov/pubmed/8412694 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417526 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417526 RefSeq WP_000046281 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000046281 SMART SM01118 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01118 SMR P30871 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P30871 STRING 511145.b3054 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3054&targetmode=cogs SUPFAM SSF55154 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55154 UniProtKB 3PASE_ECOLI http://www.uniprot.org/uniprot/3PASE_ECOLI UniProtKB-AC P30871 http://www.uniprot.org/uniprot/P30871 charge swissprot:3PASE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:3PASE_ECOLI eggNOG COG3025 http://eggnogapi.embl.de/nog_data/html/tree/COG3025 eggNOG ENOG4105I7R http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105I7R epestfind swissprot:3PASE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:3PASE_ECOLI garnier swissprot:3PASE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:3PASE_ECOLI helixturnhelix swissprot:3PASE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:3PASE_ECOLI hmoment swissprot:3PASE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:3PASE_ECOLI iep swissprot:3PASE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:3PASE_ECOLI inforesidue swissprot:3PASE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:3PASE_ECOLI octanol swissprot:3PASE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:3PASE_ECOLI pepcoil swissprot:3PASE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:3PASE_ECOLI pepdigest swissprot:3PASE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:3PASE_ECOLI pepinfo swissprot:3PASE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:3PASE_ECOLI pepnet swissprot:3PASE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:3PASE_ECOLI pepstats swissprot:3PASE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:3PASE_ECOLI pepwheel swissprot:3PASE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:3PASE_ECOLI pepwindow swissprot:3PASE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:3PASE_ECOLI sigcleave swissprot:3PASE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:3PASE_ECOLI ## Database ID URL or Descriptions # AltName INTR_ECOLI Putative lambdoid prophage Rac integrase # BioGrid 4261947 7 # EcoGene EG13358 intR # FUNCTION INTR_ECOLI Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome (By similarity). {ECO 0000250}. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_process GO:0006310 DNA recombination; IEA:UniProtKB-KW. # GO_process GO:0015074 DNA integration; IEA:UniProtKB-KW. # GO_process GO:0046718 viral entry into host cell; IEA:UniProtKB-KW. # GO_process GO:0075713 establishment of integrated proviral latency; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0044403 symbiosis, encompassing mutualism through parasitism # Gene3D 1.10.150.130 -; 1. # Gene3D 1.10.443.10 -; 1. # IntAct P76056 6 # InterPro IPR002104 Integrase_catalytic # InterPro IPR011010 DNA_brk_join_enz # InterPro IPR013762 Integrase-like_cat # InterPro IPR022000 DUF3596 # InterPro IPR023109 Integrase_recombinase_N # Organism INTR_ECOLI Escherichia coli (strain K12) # PATRIC 32117970 VBIEscCol129921_1405 # PIR D64884 D64884 # Pfam PF00589 Phage_integrase # Pfam PF12167 DUF3596 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Prophage integrase IntR {ECO 0000305} # RefSeq NP_415861 NC_000913.3 # SIMILARITY Belongs to the 'phage' integrase family. {ECO 0000305}. # SUPFAM SSF56349 SSF56349 # eggNOG COG0582 LUCA # eggNOG ENOG4107R08 Bacteria BLAST swissprot:INTR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INTR_ECOLI BioCyc ECOL316407:JW1339-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1339-MONOMER BioCyc EcoCyc:G6676-MONOMER http://biocyc.org/getid?id=EcoCyc:G6676-MONOMER COG COG0582 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0582 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3141 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3141 EcoGene EG13358 http://www.ecogene.org/geneInfo.php?eg_id=EG13358 EnsemblBacteria AAC74427 http://www.ensemblgenomes.org/id/AAC74427 EnsemblBacteria AAC74427 http://www.ensemblgenomes.org/id/AAC74427 EnsemblBacteria BAE76408 http://www.ensemblgenomes.org/id/BAE76408 EnsemblBacteria BAE76408 http://www.ensemblgenomes.org/id/BAE76408 EnsemblBacteria BAE76408 http://www.ensemblgenomes.org/id/BAE76408 EnsemblBacteria b1345 http://www.ensemblgenomes.org/id/b1345 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0015074 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015074 GO_process GO:0046718 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046718 GO_process GO:0075713 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0075713 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0044403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403 Gene3D 1.10.150.130 http://www.cathdb.info/version/latest/superfamily/1.10.150.130 Gene3D 1.10.443.10 http://www.cathdb.info/version/latest/superfamily/1.10.443.10 GeneID 946976 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946976 HOGENOM HOG000120142 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120142&db=HOGENOM6 InParanoid P76056 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76056 IntAct P76056 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76056* InterPro IPR002104 http://www.ebi.ac.uk/interpro/entry/IPR002104 InterPro IPR011010 http://www.ebi.ac.uk/interpro/entry/IPR011010 InterPro IPR013762 http://www.ebi.ac.uk/interpro/entry/IPR013762 InterPro IPR022000 http://www.ebi.ac.uk/interpro/entry/IPR022000 InterPro IPR023109 http://www.ebi.ac.uk/interpro/entry/IPR023109 KEGG_Gene ecj:JW1339 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1339 KEGG_Gene eco:b1345 http://www.genome.jp/dbget-bin/www_bget?eco:b1345 KEGG_Orthology KO:K14059 http://www.genome.jp/dbget-bin/www_bget?KO:K14059 OMA LIVHEIS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LIVHEIS PSORT swissprot:INTR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INTR_ECOLI PSORT-B swissprot:INTR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INTR_ECOLI PSORT2 swissprot:INTR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INTR_ECOLI Pfam PF00589 http://pfam.xfam.org/family/PF00589 Pfam PF12167 http://pfam.xfam.org/family/PF12167 Phobius swissprot:INTR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INTR_ECOLI PhylomeDB P76056 http://phylomedb.org/?seqid=P76056 ProteinModelPortal P76056 http://www.proteinmodelportal.org/query/uniprot/P76056 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415861 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415861 SMR P76056 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76056 STRING 511145.b1345 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1345&targetmode=cogs STRING COG0582 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0582&targetmode=cogs SUPFAM SSF56349 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56349 UniProtKB INTR_ECOLI http://www.uniprot.org/uniprot/INTR_ECOLI UniProtKB-AC P76056 http://www.uniprot.org/uniprot/P76056 charge swissprot:INTR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INTR_ECOLI eggNOG COG0582 http://eggnogapi.embl.de/nog_data/html/tree/COG0582 eggNOG ENOG4107R08 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107R08 epestfind swissprot:INTR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INTR_ECOLI garnier swissprot:INTR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INTR_ECOLI helixturnhelix swissprot:INTR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INTR_ECOLI hmoment swissprot:INTR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INTR_ECOLI iep swissprot:INTR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INTR_ECOLI inforesidue swissprot:INTR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INTR_ECOLI octanol swissprot:INTR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INTR_ECOLI pepcoil swissprot:INTR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INTR_ECOLI pepdigest swissprot:INTR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INTR_ECOLI pepinfo swissprot:INTR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INTR_ECOLI pepnet swissprot:INTR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INTR_ECOLI pepstats swissprot:INTR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INTR_ECOLI pepwheel swissprot:INTR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INTR_ECOLI pepwindow swissprot:INTR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INTR_ECOLI sigcleave swissprot:INTR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INTR_ECOLI ## Database ID URL or Descriptions # BioGrid 4259469 6 # EcoGene EG14399 ypfN # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # HAMAP MF_01566 UPF0370 # InterPro IPR020910 UPF0370 # Organism YPFN_ECOLI Escherichia coli (strain K12) # PATRIC 32120329 VBIEscCol129921_2567 # PIR D42959 D42959 # Pfam PF13980 UPF0370 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UPF0370 protein YpfN {ECO:0000255|HAMAP-Rule MF_01566} # RefSeq WP_000383836 NZ_LN832404.1 # RefSeq YP_588465 NC_000913.3 # SIMILARITY Belongs to the UPF0370 family. {ECO:0000255|HAMAP- Rule MF_01566}. # SUBCELLULAR LOCATION YPFN_ECOLI Cell membrane {ECO 0000255|HAMAP- Rule MF_01566}; Single-pass membrane protein {ECO 0000255|HAMAP- Rule MF_01566}. # eggNOG ENOG4105XYK Bacteria # eggNOG ENOG41125PA LUCA BLAST swissprot:YPFN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YPFN_ECOLI BioCyc ECOL316407:JW2457-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2457-MONOMER BioCyc EcoCyc:MONOMER0-2685 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2685 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X57403 http://www.ebi.ac.uk/ena/data/view/X57403 EcoGene EG14399 http://www.ecogene.org/geneInfo.php?eg_id=EG14399 EnsemblBacteria ABD18697 http://www.ensemblgenomes.org/id/ABD18697 EnsemblBacteria ABD18697 http://www.ensemblgenomes.org/id/ABD18697 EnsemblBacteria BAA16347 http://www.ensemblgenomes.org/id/BAA16347 EnsemblBacteria BAA16347 http://www.ensemblgenomes.org/id/BAA16347 EnsemblBacteria BAA16347 http://www.ensemblgenomes.org/id/BAA16347 EnsemblBacteria b4547 http://www.ensemblgenomes.org/id/b4547 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 1450286 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1450286 HAMAP MF_01566 http://hamap.expasy.org/unirule/MF_01566 HOGENOM HOG000290431 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000290431&db=HOGENOM6 InterPro IPR020910 http://www.ebi.ac.uk/interpro/entry/IPR020910 KEGG_Gene ecj:JW2457 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2457 KEGG_Gene eco:b4547 http://www.genome.jp/dbget-bin/www_bget?eco:b4547 OMA DDWPQKK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DDWPQKK PSORT swissprot:YPFN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YPFN_ECOLI PSORT-B swissprot:YPFN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YPFN_ECOLI PSORT2 swissprot:YPFN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YPFN_ECOLI Pfam PF13980 http://pfam.xfam.org/family/PF13980 Phobius swissprot:YPFN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YPFN_ECOLI ProteinModelPortal Q2EET2 http://www.proteinmodelportal.org/query/uniprot/Q2EET2 PubMed 1644752 http://www.ncbi.nlm.nih.gov/pubmed/1644752 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000383836 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000383836 RefSeq YP_588465 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_588465 STRING 511145.b4547 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4547&targetmode=cogs UniProtKB YPFN_ECOLI http://www.uniprot.org/uniprot/YPFN_ECOLI UniProtKB-AC Q2EET2 http://www.uniprot.org/uniprot/Q2EET2 charge swissprot:YPFN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YPFN_ECOLI eggNOG ENOG4105XYK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105XYK eggNOG ENOG41125PA http://eggnogapi.embl.de/nog_data/html/tree/ENOG41125PA epestfind swissprot:YPFN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YPFN_ECOLI garnier swissprot:YPFN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YPFN_ECOLI helixturnhelix swissprot:YPFN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YPFN_ECOLI hmoment swissprot:YPFN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YPFN_ECOLI iep swissprot:YPFN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YPFN_ECOLI inforesidue swissprot:YPFN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YPFN_ECOLI octanol swissprot:YPFN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YPFN_ECOLI pepcoil swissprot:YPFN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YPFN_ECOLI pepdigest swissprot:YPFN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YPFN_ECOLI pepinfo swissprot:YPFN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YPFN_ECOLI pepnet swissprot:YPFN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YPFN_ECOLI pepstats swissprot:YPFN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YPFN_ECOLI pepwheel swissprot:YPFN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YPFN_ECOLI pepwindow swissprot:YPFN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YPFN_ECOLI sigcleave swissprot:YPFN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YPFN_ECOLI ## Database ID URL or Descriptions # BioGrid 4262102 11 # EcoGene EG10474 hycA # FUNCTION HYCA_ECOLI Regulatory protein for the formate hydrogenlyase system. Could act by directly interacting with FhlA or by preventing the binding of FhlA to the upstream activatory sequence. {ECO 0000269|PubMed 1625581}. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IMP:EcoCyc. # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # InterPro IPR021285 Tscrpt_reg_HycA # Organism HYCA_ECOLI Escherichia coli (strain K12) # PATRIC 32120850 VBIEscCol129921_2817 # PIR S08619 S08619 # Pfam PF11046 HycA_repressor # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HYCA_ECOLI Formate hydrogenlyase regulatory protein HycA # RefSeq NP_417205 NC_000913.3 # RefSeq WP_000158056 NZ_LN832404.1 # eggNOG ENOG4108VRC Bacteria # eggNOG ENOG4111JXQ LUCA BLAST swissprot:HYCA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HYCA_ECOLI BioCyc ECOL316407:JW2695-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2695-MONOMER BioCyc EcoCyc:EG10474-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10474-MONOMER DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1990.tb00590.x http://dx.doi.org/10.1111/j.1365-2958.1990.tb00590.x DOI 10.1111/j.1365-2958.1992.tb00873.x http://dx.doi.org/10.1111/j.1365-2958.1992.tb00873.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EMBL X17506 http://www.ebi.ac.uk/ena/data/view/X17506 EchoBASE EB0469 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0469 EcoGene EG10474 http://www.ecogene.org/geneInfo.php?eg_id=EG10474 EnsemblBacteria AAC75767 http://www.ensemblgenomes.org/id/AAC75767 EnsemblBacteria AAC75767 http://www.ensemblgenomes.org/id/AAC75767 EnsemblBacteria BAE76802 http://www.ensemblgenomes.org/id/BAE76802 EnsemblBacteria BAE76802 http://www.ensemblgenomes.org/id/BAE76802 EnsemblBacteria BAE76802 http://www.ensemblgenomes.org/id/BAE76802 EnsemblBacteria b2725 http://www.ensemblgenomes.org/id/b2725 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 947193 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947193 HOGENOM HOG000124058 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000124058&db=HOGENOM6 IntAct P0AEV4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEV4* InterPro IPR021285 http://www.ebi.ac.uk/interpro/entry/IPR021285 KEGG_Gene ecj:JW2695 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2695 KEGG_Gene eco:b2725 http://www.genome.jp/dbget-bin/www_bget?eco:b2725 KEGG_Orthology KO:K15833 http://www.genome.jp/dbget-bin/www_bget?KO:K15833 OMA HAMSCAA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HAMSCAA PSORT swissprot:HYCA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HYCA_ECOLI PSORT-B swissprot:HYCA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HYCA_ECOLI PSORT2 swissprot:HYCA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HYCA_ECOLI Pfam PF11046 http://pfam.xfam.org/family/PF11046 Phobius swissprot:HYCA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HYCA_ECOLI ProteinModelPortal P0AEV4 http://www.proteinmodelportal.org/query/uniprot/P0AEV4 PubMed 1625581 http://www.ncbi.nlm.nih.gov/pubmed/1625581 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2187144 http://www.ncbi.nlm.nih.gov/pubmed/2187144 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417205 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417205 RefSeq WP_000158056 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000158056 STRING 511145.b2725 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2725&targetmode=cogs UniProtKB HYCA_ECOLI http://www.uniprot.org/uniprot/HYCA_ECOLI UniProtKB-AC P0AEV4 http://www.uniprot.org/uniprot/P0AEV4 charge swissprot:HYCA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HYCA_ECOLI eggNOG ENOG4108VRC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108VRC eggNOG ENOG4111JXQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111JXQ epestfind swissprot:HYCA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HYCA_ECOLI garnier swissprot:HYCA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HYCA_ECOLI helixturnhelix swissprot:HYCA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HYCA_ECOLI hmoment swissprot:HYCA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HYCA_ECOLI iep swissprot:HYCA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HYCA_ECOLI inforesidue swissprot:HYCA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HYCA_ECOLI octanol swissprot:HYCA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HYCA_ECOLI pepcoil swissprot:HYCA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HYCA_ECOLI pepdigest swissprot:HYCA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HYCA_ECOLI pepinfo swissprot:HYCA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HYCA_ECOLI pepnet swissprot:HYCA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HYCA_ECOLI pepstats swissprot:HYCA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HYCA_ECOLI pepwheel swissprot:HYCA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HYCA_ECOLI pepwindow swissprot:HYCA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HYCA_ECOLI sigcleave swissprot:HYCA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HYCA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262412 11 # EcoGene EG12744 yqjE # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR009937 Phage_holin_3_6 # Organism YQJE_ECOLI Escherichia coli (strain K12) # PATRIC 32121618 VBIEscCol129921_3195 # PIR H65098 H65098 # Pfam PF07332 Phage_holin_3_6 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQJE_ECOLI Inner membrane protein YqjE # RefSeq NP_417570 NC_000913.3 # RefSeq WP_000785722 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA57903.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SUBCELLULAR LOCATION YQJE_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 1.E.34.2 the putative actinobacterial holin-x (hol-x) family # eggNOG COG5393 LUCA # eggNOG ENOG41090KG Bacteria BLAST swissprot:YQJE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQJE_ECOLI BioCyc ECOL316407:JW3070-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3070-MONOMER BioCyc EcoCyc:G7613-MONOMER http://biocyc.org/getid?id=EcoCyc:G7613-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2600 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2600 EcoGene EG12744 http://www.ecogene.org/geneInfo.php?eg_id=EG12744 EnsemblBacteria AAC76134 http://www.ensemblgenomes.org/id/AAC76134 EnsemblBacteria AAC76134 http://www.ensemblgenomes.org/id/AAC76134 EnsemblBacteria BAE77149 http://www.ensemblgenomes.org/id/BAE77149 EnsemblBacteria BAE77149 http://www.ensemblgenomes.org/id/BAE77149 EnsemblBacteria BAE77149 http://www.ensemblgenomes.org/id/BAE77149 EnsemblBacteria b3099 http://www.ensemblgenomes.org/id/b3099 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 947611 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947611 HOGENOM HOG000256764 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000256764&db=HOGENOM6 IntAct P64585 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P64585* InterPro IPR009937 http://www.ebi.ac.uk/interpro/entry/IPR009937 KEGG_Gene ecj:JW3070 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3070 KEGG_Gene eco:b3099 http://www.genome.jp/dbget-bin/www_bget?eco:b3099 OMA IIWAVDA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IIWAVDA PSORT swissprot:YQJE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQJE_ECOLI PSORT-B swissprot:YQJE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQJE_ECOLI PSORT2 swissprot:YQJE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQJE_ECOLI Pfam PF07332 http://pfam.xfam.org/family/PF07332 Phobius swissprot:YQJE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQJE_ECOLI ProteinModelPortal P64585 http://www.proteinmodelportal.org/query/uniprot/P64585 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417570 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417570 RefSeq WP_000785722 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000785722 STRING 511145.b3099 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3099&targetmode=cogs TCDB 1.E.34.2 http://www.tcdb.org/search/result.php?tc=1.E.34.2 UniProtKB YQJE_ECOLI http://www.uniprot.org/uniprot/YQJE_ECOLI UniProtKB-AC P64585 http://www.uniprot.org/uniprot/P64585 charge swissprot:YQJE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQJE_ECOLI eggNOG COG5393 http://eggnogapi.embl.de/nog_data/html/tree/COG5393 eggNOG ENOG41090KG http://eggnogapi.embl.de/nog_data/html/tree/ENOG41090KG epestfind swissprot:YQJE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQJE_ECOLI garnier swissprot:YQJE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQJE_ECOLI helixturnhelix swissprot:YQJE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQJE_ECOLI hmoment swissprot:YQJE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQJE_ECOLI iep swissprot:YQJE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQJE_ECOLI inforesidue swissprot:YQJE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQJE_ECOLI octanol swissprot:YQJE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQJE_ECOLI pepcoil swissprot:YQJE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQJE_ECOLI pepdigest swissprot:YQJE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQJE_ECOLI pepinfo swissprot:YQJE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQJE_ECOLI pepnet swissprot:YQJE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQJE_ECOLI pepstats swissprot:YQJE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQJE_ECOLI pepwheel swissprot:YQJE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQJE_ECOLI pepwindow swissprot:YQJE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQJE_ECOLI sigcleave swissprot:YQJE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQJE_ECOLI ## Database ID URL or Descriptions # BioGrid 4260878 292 # EcoGene EG12475 yjeM # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0015179 L-amino acid transmembrane transporter activity; IBA:GO_Central. # GO_function GO:0015297 antiporter activity; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # InterPro IPR002293 AA/rel_permease1 # Organism YJEM_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11785 PTHR11785 # PATRIC 32123885 VBIEscCol129921_4290 # PIR S56384 S56384 # PIRSF PIRSF006060 AA_transporter # Pfam PF13520 AA_permease_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJEM_ECOLI Inner membrane transporter YjeM # RefSeq NP_418580 NC_000913.3 # RefSeq WP_001336293 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97055.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the amino acid-polyamine-organocation (APC) superfamily. {ECO 0000305}. # SUBCELLULAR LOCATION YJEM_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.3.7 the amino acid-polyamine-organocation (apc) family # eggNOG ENOG4107SC7 Bacteria # eggNOG ENOG410XRYB LUCA BLAST swissprot:YJEM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJEM_ECOLI BioCyc ECOL316407:JW5739-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5739-MONOMER BioCyc EcoCyc:YJEM-MONOMER http://biocyc.org/getid?id=EcoCyc:YJEM-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2368 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2368 EcoGene EG12475 http://www.ecogene.org/geneInfo.php?eg_id=EG12475 EnsemblBacteria AAC77116 http://www.ensemblgenomes.org/id/AAC77116 EnsemblBacteria AAC77116 http://www.ensemblgenomes.org/id/AAC77116 EnsemblBacteria BAE78160 http://www.ensemblgenomes.org/id/BAE78160 EnsemblBacteria BAE78160 http://www.ensemblgenomes.org/id/BAE78160 EnsemblBacteria BAE78160 http://www.ensemblgenomes.org/id/BAE78160 EnsemblBacteria b4156 http://www.ensemblgenomes.org/id/b4156 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015179 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015179 GO_function GO:0015297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015297 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GeneID 948679 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948679 HOGENOM HOG000127295 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000127295&db=HOGENOM6 InParanoid P39282 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39282 InterPro IPR002293 http://www.ebi.ac.uk/interpro/entry/IPR002293 KEGG_Gene ecj:JW5739 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5739 KEGG_Gene eco:b4156 http://www.genome.jp/dbget-bin/www_bget?eco:b4156 OMA VVWMVST http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VVWMVST PANTHER PTHR11785 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11785 PSORT swissprot:YJEM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJEM_ECOLI PSORT-B swissprot:YJEM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJEM_ECOLI PSORT2 swissprot:YJEM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJEM_ECOLI Pfam PF13520 http://pfam.xfam.org/family/PF13520 Phobius swissprot:YJEM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJEM_ECOLI PhylomeDB P39282 http://phylomedb.org/?seqid=P39282 ProteinModelPortal P39282 http://www.proteinmodelportal.org/query/uniprot/P39282 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418580 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418580 RefSeq WP_001336293 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001336293 STRING 511145.b4156 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4156&targetmode=cogs TCDB 2.A.3.7 http://www.tcdb.org/search/result.php?tc=2.A.3.7 UniProtKB YJEM_ECOLI http://www.uniprot.org/uniprot/YJEM_ECOLI UniProtKB-AC P39282 http://www.uniprot.org/uniprot/P39282 charge swissprot:YJEM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJEM_ECOLI eggNOG ENOG4107SC7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107SC7 eggNOG ENOG410XRYB http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRYB epestfind swissprot:YJEM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJEM_ECOLI garnier swissprot:YJEM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJEM_ECOLI helixturnhelix swissprot:YJEM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJEM_ECOLI hmoment swissprot:YJEM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJEM_ECOLI iep swissprot:YJEM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJEM_ECOLI inforesidue swissprot:YJEM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJEM_ECOLI octanol swissprot:YJEM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJEM_ECOLI pepcoil swissprot:YJEM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJEM_ECOLI pepdigest swissprot:YJEM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJEM_ECOLI pepinfo swissprot:YJEM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJEM_ECOLI pepnet swissprot:YJEM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJEM_ECOLI pepstats swissprot:YJEM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJEM_ECOLI pepwheel swissprot:YJEM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJEM_ECOLI pepwindow swissprot:YJEM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJEM_ECOLI sigcleave swissprot:YJEM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJEM_ECOLI ## Database ID URL or Descriptions # BioGrid 4259565 5 # EcoGene EG10106 atpI # FUNCTION ATPZ_ECOLI A possible function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_component GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o); IEA:UniProtKB-KW. # GO_process GO:0015992 proton transport; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_process GO:0006810 transport # InterPro IPR005598 ATP_synth_I # KEGG_Brite ko00194 Photosynthesis proteins # Organism ATPZ_ECOLI Escherichia coli (strain K12) # PATRIC 32122975 VBIEscCol129921_3863 # Pfam PF03899 ATP-synt_I # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ATPZ_ECOLI ATP synthase protein I # RefSeq NP_418195 NC_000913.3 # RefSeq WP_000116695 NZ_LN832404.1 # SEQUENCE CAUTION ATPZ_ECOLI Sequence=AAA24730.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=AAA62091.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=AAA83868.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=CAA23513.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=CAA25640.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=CAA25775.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the bacterial AtpI family. {ECO 0000305}. # SUBCELLULAR LOCATION ATPZ_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG COG3312 LUCA # eggNOG ENOG4105GXX Bacteria BLAST swissprot:ATPZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ATPZ_ECOLI BioCyc ECOL316407:JW5611-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5611-MONOMER BioCyc EcoCyc:EG10106-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10106-MONOMER COG COG3312 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3312 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1007/BF00271191 http://dx.doi.org/10.1007/BF00271191 DOI 10.1007/BF00327415 http://dx.doi.org/10.1007/BF00327415 DOI 10.1016/0006-291X(82)91529-7 http://dx.doi.org/10.1016/0006-291X(82)91529-7 DOI 10.1016/0304-4173(84)90003-X http://dx.doi.org/10.1016/0304-4173(84)90003-X DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2240799 http://dx.doi.org/10.1042/bj2240799 DOI 10.1093/nar/9.16.3919 http://dx.doi.org/10.1093/nar/9.16.3919 DOI 10.1111/j.1749-6632.1982.tb25731.x http://dx.doi.org/10.1111/j.1749-6632.1982.tb25731.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01594 http://www.ebi.ac.uk/ena/data/view/J01594 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M25464 http://www.ebi.ac.uk/ena/data/view/M25464 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00264 http://www.ebi.ac.uk/ena/data/view/V00264 EMBL X01383 http://www.ebi.ac.uk/ena/data/view/X01383 EMBL X01631 http://www.ebi.ac.uk/ena/data/view/X01631 EchoBASE EB0104 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0104 EcoGene EG10106 http://www.ecogene.org/geneInfo.php?eg_id=EG10106 EnsemblBacteria AAC76762 http://www.ensemblgenomes.org/id/AAC76762 EnsemblBacteria AAC76762 http://www.ensemblgenomes.org/id/AAC76762 EnsemblBacteria BAE77549 http://www.ensemblgenomes.org/id/BAE77549 EnsemblBacteria BAE77549 http://www.ensemblgenomes.org/id/BAE77549 EnsemblBacteria BAE77549 http://www.ensemblgenomes.org/id/BAE77549 EnsemblBacteria b3739 http://www.ensemblgenomes.org/id/b3739 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0045263 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045263 GO_process GO:0015992 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015992 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948251 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948251 HOGENOM HOG000253861 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000253861&db=HOGENOM6 InterPro IPR005598 http://www.ebi.ac.uk/interpro/entry/IPR005598 KEGG_Brite ko00194 http://www.genome.jp/dbget-bin/www_bget?ko00194 KEGG_Gene ecj:JW5611 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5611 KEGG_Gene eco:b3739 http://www.genome.jp/dbget-bin/www_bget?eco:b3739 KEGG_Orthology KO:K02116 http://www.genome.jp/dbget-bin/www_bget?KO:K02116 OMA SIEWGAS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SIEWGAS PSORT swissprot:ATPZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ATPZ_ECOLI PSORT-B swissprot:ATPZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ATPZ_ECOLI PSORT2 swissprot:ATPZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ATPZ_ECOLI Pfam PF03899 http://pfam.xfam.org/family/PF03899 Phobius swissprot:ATPZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ATPZ_ECOLI ProteinModelPortal P0ABC0 http://www.proteinmodelportal.org/query/uniprot/P0ABC0 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2136739 http://www.ncbi.nlm.nih.gov/pubmed/2136739 PubMed 6206892 http://www.ncbi.nlm.nih.gov/pubmed/6206892 PubMed 6215041 http://www.ncbi.nlm.nih.gov/pubmed/6215041 PubMed 6272190 http://www.ncbi.nlm.nih.gov/pubmed/6272190 PubMed 6278247 http://www.ncbi.nlm.nih.gov/pubmed/6278247 PubMed 6301339 http://www.ncbi.nlm.nih.gov/pubmed/6301339 PubMed 6318052 http://www.ncbi.nlm.nih.gov/pubmed/6318052 PubMed 6327640 http://www.ncbi.nlm.nih.gov/pubmed/6327640 PubMed 6395859 http://www.ncbi.nlm.nih.gov/pubmed/6395859 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418195 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418195 RefSeq WP_000116695 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000116695 STRING 511145.b3739 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3739&targetmode=cogs STRING COG3312 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3312&targetmode=cogs UniProtKB ATPZ_ECOLI http://www.uniprot.org/uniprot/ATPZ_ECOLI UniProtKB-AC P0ABC0 http://www.uniprot.org/uniprot/P0ABC0 charge swissprot:ATPZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ATPZ_ECOLI eggNOG COG3312 http://eggnogapi.embl.de/nog_data/html/tree/COG3312 eggNOG ENOG4105GXX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105GXX epestfind swissprot:ATPZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ATPZ_ECOLI garnier swissprot:ATPZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ATPZ_ECOLI helixturnhelix swissprot:ATPZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ATPZ_ECOLI hmoment swissprot:ATPZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ATPZ_ECOLI iep swissprot:ATPZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ATPZ_ECOLI inforesidue swissprot:ATPZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ATPZ_ECOLI octanol swissprot:ATPZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ATPZ_ECOLI pepcoil swissprot:ATPZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ATPZ_ECOLI pepdigest swissprot:ATPZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ATPZ_ECOLI pepinfo swissprot:ATPZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ATPZ_ECOLI pepnet swissprot:ATPZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ATPZ_ECOLI pepstats swissprot:ATPZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ATPZ_ECOLI pepwheel swissprot:ATPZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ATPZ_ECOLI pepwindow swissprot:ATPZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ATPZ_ECOLI sigcleave swissprot:ATPZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ATPZ_ECOLI ## Database ID URL or Descriptions # BioGrid 4260494 15 # EcoGene EG11422 inaA # FUNCTION INAA_ECOLI May be an environmental sensor responsive to several stimuli, including internal pH, proton motive force, temperature, and possibly other unknown factors. # GO_component GO:0016020 membrane; IEA:InterPro. # GO_function GO:0005524 ATP binding; IEA:InterPro. # GO_function GO:0016773 phosphotransferase activity, alcohol group as acceptor; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # INDUCTION INAA_ECOLI By several factors in addition of internal pH. # IntAct P27294 13 # InterPro IPR010440 LipoPS_kinase # InterPro IPR011009 Kinase-like_dom # InterPro IPR027023 Put_LipoPS_kinase_InaA # Organism INAA_ECOLI Escherichia coli (strain K12) # PATRIC 32119833 VBIEscCol129921_2326 # PIR C64994 C64994 # PIRSF PIRSF026326 InaA # Pfam PF06293 Kdo # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INAA_ECOLI Protein InaA # RefSeq NP_416740 NC_000913.3 # RefSeq WP_000301050 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=K02672; Type=Frameshift; Positions=43; Evidence={ECO 0000305}; # SIMILARITY Belongs to the protein kinase superfamily. KdkA/RfaP family. {ECO 0000305}. # SUPFAM SSF56112 SSF56112 # eggNOG ENOG4105FQR Bacteria # eggNOG ENOG4111Q68 LUCA BLAST swissprot:INAA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INAA_ECOLI BioCyc ECOL316407:JW2231-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2231-MONOMER BioCyc EcoCyc:EG11422-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11422-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.81.14.4294 http://dx.doi.org/10.1073/pnas.81.14.4294 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K02672 http://www.ebi.ac.uk/ena/data/view/K02672 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1392 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1392 EcoGene EG11422 http://www.ecogene.org/geneInfo.php?eg_id=EG11422 EnsemblBacteria AAC75297 http://www.ensemblgenomes.org/id/AAC75297 EnsemblBacteria AAC75297 http://www.ensemblgenomes.org/id/AAC75297 EnsemblBacteria BAA16056 http://www.ensemblgenomes.org/id/BAA16056 EnsemblBacteria BAA16056 http://www.ensemblgenomes.org/id/BAA16056 EnsemblBacteria BAA16056 http://www.ensemblgenomes.org/id/BAA16056 EnsemblBacteria b2237 http://www.ensemblgenomes.org/id/b2237 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016773 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016773 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GeneID 946731 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946731 HOGENOM HOG000122400 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122400&db=HOGENOM6 InParanoid P27294 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P27294 IntAct P27294 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P27294* InterPro IPR010440 http://www.ebi.ac.uk/interpro/entry/IPR010440 InterPro IPR011009 http://www.ebi.ac.uk/interpro/entry/IPR011009 InterPro IPR027023 http://www.ebi.ac.uk/interpro/entry/IPR027023 KEGG_Gene ecj:JW2231 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2231 KEGG_Gene eco:b2237 http://www.genome.jp/dbget-bin/www_bget?eco:b2237 OMA HPFGRPT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HPFGRPT PSORT swissprot:INAA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INAA_ECOLI PSORT-B swissprot:INAA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INAA_ECOLI PSORT2 swissprot:INAA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INAA_ECOLI Pfam PF06293 http://pfam.xfam.org/family/PF06293 Phobius swissprot:INAA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INAA_ECOLI PhylomeDB P27294 http://phylomedb.org/?seqid=P27294 ProteinModelPortal P27294 http://www.proteinmodelportal.org/query/uniprot/P27294 PubMed 1537798 http://www.ncbi.nlm.nih.gov/pubmed/1537798 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6087316 http://www.ncbi.nlm.nih.gov/pubmed/6087316 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416740 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416740 RefSeq WP_000301050 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000301050 STRING 511145.b2237 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2237&targetmode=cogs SUPFAM SSF56112 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56112 UniProtKB INAA_ECOLI http://www.uniprot.org/uniprot/INAA_ECOLI UniProtKB-AC P27294 http://www.uniprot.org/uniprot/P27294 charge swissprot:INAA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INAA_ECOLI eggNOG ENOG4105FQR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FQR eggNOG ENOG4111Q68 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111Q68 epestfind swissprot:INAA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INAA_ECOLI garnier swissprot:INAA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INAA_ECOLI helixturnhelix swissprot:INAA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INAA_ECOLI hmoment swissprot:INAA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INAA_ECOLI iep swissprot:INAA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INAA_ECOLI inforesidue swissprot:INAA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INAA_ECOLI octanol swissprot:INAA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INAA_ECOLI pepcoil swissprot:INAA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INAA_ECOLI pepdigest swissprot:INAA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INAA_ECOLI pepinfo swissprot:INAA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INAA_ECOLI pepnet swissprot:INAA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INAA_ECOLI pepstats swissprot:INAA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INAA_ECOLI pepwheel swissprot:INAA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INAA_ECOLI pepwindow swissprot:INAA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INAA_ECOLI sigcleave swissprot:INAA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INAA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261722 58 # EcoGene EG11491 dinF # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015238 drug transmembrane transporter activity; IBA:GO_Central. # GO_function GO:0015297 antiporter activity; IEA:InterPro. # GO_process GO:0006855 drug transmembrane transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0055085 transmembrane transport # INDUCTION DINF_ECOLI By DNA damage. # InterPro IPR002528 MATE_fam # KEGG_Brite ko02001 Solute carrier family # Organism DINF_ECOLI Escherichia coli (strain K12) # PATRIC 32123625 VBIEscCol129921_4161 # PIR C65212 C65212 # Pfam PF01554 MatE; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DINF_ECOLI DNA-damage-inducible protein F # RefSeq NP_418468 NC_000913.3 # SIMILARITY Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. {ECO 0000305}. # SUBCELLULAR LOCATION DINF_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # TCDB 2.A.66.1 the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily # TIGRFAMs TIGR00797 matE # eggNOG COG0534 LUCA # eggNOG ENOG4107R73 Bacteria BLAST swissprot:DINF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DINF_ECOLI BioCyc ECOL316407:JW4004-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4004-MONOMER BioCyc EcoCyc:DINF-MONOMER http://biocyc.org/getid?id=EcoCyc:DINF-MONOMER COG COG0534 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0534 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L02362 http://www.ebi.ac.uk/ena/data/view/L02362 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1454 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1454 EcoGene EG11491 http://www.ecogene.org/geneInfo.php?eg_id=EG11491 EnsemblBacteria AAC77014 http://www.ensemblgenomes.org/id/AAC77014 EnsemblBacteria AAC77014 http://www.ensemblgenomes.org/id/AAC77014 EnsemblBacteria BAE78046 http://www.ensemblgenomes.org/id/BAE78046 EnsemblBacteria BAE78046 http://www.ensemblgenomes.org/id/BAE78046 EnsemblBacteria BAE78046 http://www.ensemblgenomes.org/id/BAE78046 EnsemblBacteria b4044 http://www.ensemblgenomes.org/id/b4044 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015238 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015238 GO_function GO:0015297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015297 GO_process GO:0006855 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006855 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 948554 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948554 HOGENOM HOG000253154 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000253154&db=HOGENOM6 InParanoid P28303 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P28303 InterPro IPR002528 http://www.ebi.ac.uk/interpro/entry/IPR002528 KEGG_Brite ko02001 http://www.genome.jp/dbget-bin/www_bget?ko02001 KEGG_Gene ecj:JW4004 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4004 KEGG_Gene eco:b4044 http://www.genome.jp/dbget-bin/www_bget?eco:b4044 KEGG_Orthology KO:K03327 http://www.genome.jp/dbget-bin/www_bget?KO:K03327 OMA QMVLGRD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QMVLGRD PSORT swissprot:DINF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DINF_ECOLI PSORT-B swissprot:DINF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DINF_ECOLI PSORT2 swissprot:DINF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DINF_ECOLI Pfam PF01554 http://pfam.xfam.org/family/PF01554 Phobius swissprot:DINF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DINF_ECOLI PhylomeDB P28303 http://phylomedb.org/?seqid=P28303 ProteinModelPortal P28303 http://www.proteinmodelportal.org/query/uniprot/P28303 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418468 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418468 STRING 511145.b4044 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4044&targetmode=cogs STRING COG0534 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0534&targetmode=cogs TCDB 2.A.66.1 http://www.tcdb.org/search/result.php?tc=2.A.66.1 TIGRFAMs TIGR00797 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00797 UniProtKB DINF_ECOLI http://www.uniprot.org/uniprot/DINF_ECOLI UniProtKB-AC P28303 http://www.uniprot.org/uniprot/P28303 charge swissprot:DINF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DINF_ECOLI eggNOG COG0534 http://eggnogapi.embl.de/nog_data/html/tree/COG0534 eggNOG ENOG4107R73 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107R73 epestfind swissprot:DINF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DINF_ECOLI garnier swissprot:DINF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DINF_ECOLI helixturnhelix swissprot:DINF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DINF_ECOLI hmoment swissprot:DINF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DINF_ECOLI iep swissprot:DINF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DINF_ECOLI inforesidue swissprot:DINF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DINF_ECOLI octanol swissprot:DINF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DINF_ECOLI pepcoil swissprot:DINF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DINF_ECOLI pepdigest swissprot:DINF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DINF_ECOLI pepinfo swissprot:DINF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DINF_ECOLI pepnet swissprot:DINF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DINF_ECOLI pepstats swissprot:DINF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DINF_ECOLI pepwheel swissprot:DINF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DINF_ECOLI pepwindow swissprot:DINF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DINF_ECOLI sigcleave swissprot:DINF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DINF_ECOLI ## Database ID URL or Descriptions # GO_component GO:0009279 cell outer membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # Gene3D 2.160.20.20 -; 2. # InterPro IPR005546 Autotransporte_beta # InterPro IPR006315 OM_autotransptr_brl # InterPro IPR011050 Pectin_lyase_fold/virulence # InterPro IPR012332 P22_tailspike_C-like # Organism YUAO_ECOLI Escherichia coli (strain K12) # PROSITE PS51208 AUTOTRANSPORTER # RecName YUAO_ECOLI Uncharacterized protein YuaO # RefSeq NP_061405 NC_002483.1 # RefSeq WP_010892528 NZ_CP014273.1 # SIMILARITY Contains 1 autotransporter (TC 1.B.12) domain. {ECO:0000255|PROSITE-ProRule PRU00556}. # SMART SM00869 Autotransporter # SUBCELLULAR LOCATION YUAO_ECOLI Cell outer membrane {ECO 0000305}; Peripheral membrane protein {ECO 0000305}. # SUPFAM SSF103515 SSF103515 # SUPFAM SSF51126 SSF51126 # TCDB 1.B.12.1 the autotransporter-1 (at-1) family # TIGRFAMs TIGR01414 autotrans_barl BLAST swissprot:YUAO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YUAO_ECOLI EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 Gene3D 2.160.20.20 http://www.cathdb.info/version/latest/superfamily/2.160.20.20 GeneID 1263513 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263513 InterPro IPR005546 http://www.ebi.ac.uk/interpro/entry/IPR005546 InterPro IPR006315 http://www.ebi.ac.uk/interpro/entry/IPR006315 InterPro IPR011050 http://www.ebi.ac.uk/interpro/entry/IPR011050 InterPro IPR012332 http://www.ebi.ac.uk/interpro/entry/IPR012332 OMA NMSIAQG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NMSIAQG PROSITE PS51208 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51208 PSORT swissprot:YUAO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YUAO_ECOLI PSORT-B swissprot:YUAO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YUAO_ECOLI PSORT2 swissprot:YUAO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YUAO_ECOLI Phobius swissprot:YUAO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YUAO_ECOLI PhylomeDB Q9JMS5 http://phylomedb.org/?seqid=Q9JMS5 ProteinModelPortal Q9JMS5 http://www.proteinmodelportal.org/query/uniprot/Q9JMS5 RefSeq NP_061405 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061405 RefSeq WP_010892528 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_010892528 SMART SM00869 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00869 SMR Q9JMS5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9JMS5 SUPFAM SSF103515 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103515 SUPFAM SSF51126 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51126 TCDB 1.B.12.1 http://www.tcdb.org/search/result.php?tc=1.B.12.1 TIGRFAMs TIGR01414 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01414 UniProtKB YUAO_ECOLI http://www.uniprot.org/uniprot/YUAO_ECOLI UniProtKB-AC Q9JMS5 http://www.uniprot.org/uniprot/Q9JMS5 charge swissprot:YUAO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YUAO_ECOLI epestfind swissprot:YUAO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YUAO_ECOLI garnier swissprot:YUAO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YUAO_ECOLI helixturnhelix swissprot:YUAO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YUAO_ECOLI hmoment swissprot:YUAO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YUAO_ECOLI iep swissprot:YUAO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YUAO_ECOLI inforesidue swissprot:YUAO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YUAO_ECOLI octanol swissprot:YUAO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YUAO_ECOLI pepcoil swissprot:YUAO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YUAO_ECOLI pepdigest swissprot:YUAO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YUAO_ECOLI pepinfo swissprot:YUAO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YUAO_ECOLI pepnet swissprot:YUAO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YUAO_ECOLI pepstats swissprot:YUAO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YUAO_ECOLI pepwheel swissprot:YUAO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YUAO_ECOLI pepwindow swissprot:YUAO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YUAO_ECOLI sigcleave swissprot:YUAO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YUAO_ECOLI ## Database ID URL or Descriptions # BRENDA 3.2.2.27 2026 # BioGrid 4263474 132 # CATALYTIC ACTIVITY UNG_ECOLI Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil. # CDD cd10027 UDG_F1 # EcoGene EG11058 ung # FUNCTION UNG_ECOLI Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0004844 uracil DNA N-glycosylase activity; IDA:EcoCyc. # GO_process GO:0097510 base-excision repair, AP site formation via deaminated base removal; IBA:GO_Central. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_process GO:0006259 DNA metabolic process # Gene3D 3.40.470.10 -; 1. # HAMAP MF_00148 UDG # INTERACTION UNG_ECOLI P0A763 ndk; NbExp=3; IntAct=EBI-559403, EBI-370139; P14739 UGI (xeno); NbExp=4; IntAct=EBI-559403, EBI-1025973; # IntAct P12295 10 # InterPro IPR002043 UDG_fam1 # InterPro IPR005122 Uracil-DNA_glycosylase-like # InterPro IPR018085 Ura-DNA_Glyclase_AS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko03410 Base excision repair # KEGG_Pathway ko05340 Primary immunodeficiency # Organism UNG_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11264 PTHR11264 # PATRIC 32120561 VBIEscCol129921_2683 # PDB 1EUG X-ray; 1.60 A; A=1-229 # PDB 1EUI X-ray; 3.20 A; A/B=2-229 # PDB 1FLZ X-ray; 2.30 A; A=2-229 # PDB 1LQG X-ray; 2.90 A; A/B=2-229 # PDB 1LQJ X-ray; 3.35 A; A/B/C/D=2-229 # PDB 1LQM X-ray; 3.20 A; A/C/E/G=2-229 # PDB 1UUG X-ray; 2.40 A; A/C=1-229 # PDB 2EUG X-ray; 1.50 A; A=1-229 # PDB 2UUG X-ray; 2.60 A; A/B=1-229 # PDB 3EUG X-ray; 1.43 A; A=1-229 # PDB 3UF7 X-ray; 1.20 A; A=1-229 # PDB 4EUG X-ray; 1.40 A; A=1-229 # PDB 5EUG X-ray; 1.60 A; A=1-229 # PIR A28175 DGECU # PROSITE PS00130 U_DNA_GLYCOSYLASE # Pfam PF03167 UDG # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UNG_ECOLI Uracil-DNA glycosylase # RefSeq NP_417075 NC_000913.3 # RefSeq WP_001262716 NZ_LN832404.1 # SIMILARITY Belongs to the uracil-DNA glycosylase family. {ECO 0000305}. # SMART SM00986 UDG # SUBCELLULAR LOCATION UNG_ECOLI Cytoplasm. # SUBUNIT UNG_ECOLI Monomer. # SUPFAM SSF52141 SSF52141 # TIGRFAMs TIGR00628 ung # eggNOG COG0692 LUCA # eggNOG ENOG4105D5S Bacteria BLAST swissprot:UNG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UNG_ECOLI BioCyc ECOL316407:JW2564-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2564-MONOMER BioCyc EcoCyc:EG11058-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11058-MONOMER BioCyc MetaCyc:EG11058-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11058-MONOMER COG COG0692 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0692 DIP DIP-11092N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11092N DOI 10.1002/(SICI)1097-0134(19990401)35:1<13::AID-PROT2>3.0.CO http://dx.doi.org/10.1002/(SICI)1097-0134(19990401)35:1<13::AID-PROT2>3.0.CO DOI 10.1006/jmbi.1999.2605 http://dx.doi.org/10.1006/jmbi.1999.2605 DOI 10.1021/bi001532v http://dx.doi.org/10.1021/bi001532v DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.272.34.21408 http://dx.doi.org/10.1074/jbc.272.34.21408 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/nar/26.21.4880 http://dx.doi.org/10.1093/nar/26.21.4880 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.2.2.27 http://www.genome.jp/dbget-bin/www_bget?EC:3.2.2.27 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D13169 http://www.ebi.ac.uk/ena/data/view/D13169 EMBL D64044 http://www.ebi.ac.uk/ena/data/view/D64044 EMBL J03725 http://www.ebi.ac.uk/ena/data/view/J03725 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.2.2.27 http://enzyme.expasy.org/EC/3.2.2.27 EchoBASE EB1051 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1051 EcoGene EG11058 http://www.ecogene.org/geneInfo.php?eg_id=EG11058 EnsemblBacteria AAC75633 http://www.ensemblgenomes.org/id/AAC75633 EnsemblBacteria AAC75633 http://www.ensemblgenomes.org/id/AAC75633 EnsemblBacteria BAA16466 http://www.ensemblgenomes.org/id/BAA16466 EnsemblBacteria BAA16466 http://www.ensemblgenomes.org/id/BAA16466 EnsemblBacteria BAA16466 http://www.ensemblgenomes.org/id/BAA16466 EnsemblBacteria b2580 http://www.ensemblgenomes.org/id/b2580 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004844 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004844 GO_process GO:0097510 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097510 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 Gene3D 3.40.470.10 http://www.cathdb.info/version/latest/superfamily/3.40.470.10 GeneID 947067 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947067 HAMAP MF_00148 http://hamap.expasy.org/unirule/MF_00148 HOGENOM HOG000229528 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000229528&db=HOGENOM6 InParanoid P12295 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P12295 IntAct P12295 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P12295* IntEnz 3.2.2.27 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.2.2.27 InterPro IPR002043 http://www.ebi.ac.uk/interpro/entry/IPR002043 InterPro IPR005122 http://www.ebi.ac.uk/interpro/entry/IPR005122 InterPro IPR018085 http://www.ebi.ac.uk/interpro/entry/IPR018085 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW2564 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2564 KEGG_Gene eco:b2580 http://www.genome.jp/dbget-bin/www_bget?eco:b2580 KEGG_Orthology KO:K03648 http://www.genome.jp/dbget-bin/www_bget?KO:K03648 KEGG_Pathway ko03410 http://www.genome.jp/kegg-bin/show_pathway?ko03410 KEGG_Pathway ko05340 http://www.genome.jp/kegg-bin/show_pathway?ko05340 MINT MINT-194643 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-194643 OMA IALIPKN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IALIPKN PANTHER PTHR11264 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11264 PDB 1EUG http://www.ebi.ac.uk/pdbe-srv/view/entry/1EUG PDB 1EUI http://www.ebi.ac.uk/pdbe-srv/view/entry/1EUI PDB 1FLZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1FLZ PDB 1LQG http://www.ebi.ac.uk/pdbe-srv/view/entry/1LQG PDB 1LQJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1LQJ PDB 1LQM http://www.ebi.ac.uk/pdbe-srv/view/entry/1LQM PDB 1UUG http://www.ebi.ac.uk/pdbe-srv/view/entry/1UUG PDB 2EUG http://www.ebi.ac.uk/pdbe-srv/view/entry/2EUG PDB 2UUG http://www.ebi.ac.uk/pdbe-srv/view/entry/2UUG PDB 3EUG http://www.ebi.ac.uk/pdbe-srv/view/entry/3EUG PDB 3UF7 http://www.ebi.ac.uk/pdbe-srv/view/entry/3UF7 PDB 4EUG http://www.ebi.ac.uk/pdbe-srv/view/entry/4EUG PDB 5EUG http://www.ebi.ac.uk/pdbe-srv/view/entry/5EUG PDBsum 1EUG http://www.ebi.ac.uk/pdbsum/1EUG PDBsum 1EUI http://www.ebi.ac.uk/pdbsum/1EUI PDBsum 1FLZ http://www.ebi.ac.uk/pdbsum/1FLZ PDBsum 1LQG http://www.ebi.ac.uk/pdbsum/1LQG PDBsum 1LQJ http://www.ebi.ac.uk/pdbsum/1LQJ PDBsum 1LQM http://www.ebi.ac.uk/pdbsum/1LQM PDBsum 1UUG http://www.ebi.ac.uk/pdbsum/1UUG PDBsum 2EUG http://www.ebi.ac.uk/pdbsum/2EUG PDBsum 2UUG http://www.ebi.ac.uk/pdbsum/2UUG PDBsum 3EUG http://www.ebi.ac.uk/pdbsum/3EUG PDBsum 3UF7 http://www.ebi.ac.uk/pdbsum/3UF7 PDBsum 4EUG http://www.ebi.ac.uk/pdbsum/4EUG PDBsum 5EUG http://www.ebi.ac.uk/pdbsum/5EUG PROSITE PS00130 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00130 PSORT swissprot:UNG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UNG_ECOLI PSORT-B swissprot:UNG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UNG_ECOLI PSORT2 swissprot:UNG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UNG_ECOLI Pfam PF03167 http://pfam.xfam.org/family/PF03167 Phobius swissprot:UNG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UNG_ECOLI PhylomeDB P12295 http://phylomedb.org/?seqid=P12295 ProteinModelPortal P12295 http://www.proteinmodelportal.org/query/uniprot/P12295 PubMed 10080896 http://www.ncbi.nlm.nih.gov/pubmed/10080896 PubMed 10090282 http://www.ncbi.nlm.nih.gov/pubmed/10090282 PubMed 11027138 http://www.ncbi.nlm.nih.gov/pubmed/11027138 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2836397 http://www.ncbi.nlm.nih.gov/pubmed/2836397 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9261156 http://www.ncbi.nlm.nih.gov/pubmed/9261156 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9776748 http://www.ncbi.nlm.nih.gov/pubmed/9776748 RefSeq NP_417075 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417075 RefSeq WP_001262716 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001262716 SMART SM00986 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00986 SMR P12295 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P12295 STRING 511145.b2580 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2580&targetmode=cogs STRING COG0692 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0692&targetmode=cogs SUPFAM SSF52141 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52141 TIGRFAMs TIGR00628 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00628 UniProtKB UNG_ECOLI http://www.uniprot.org/uniprot/UNG_ECOLI UniProtKB-AC P12295 http://www.uniprot.org/uniprot/P12295 charge swissprot:UNG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UNG_ECOLI eggNOG COG0692 http://eggnogapi.embl.de/nog_data/html/tree/COG0692 eggNOG ENOG4105D5S http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D5S epestfind swissprot:UNG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UNG_ECOLI garnier swissprot:UNG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UNG_ECOLI helixturnhelix swissprot:UNG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UNG_ECOLI hmoment swissprot:UNG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UNG_ECOLI iep swissprot:UNG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UNG_ECOLI inforesidue swissprot:UNG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UNG_ECOLI octanol swissprot:UNG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UNG_ECOLI pepcoil swissprot:UNG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UNG_ECOLI pepdigest swissprot:UNG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UNG_ECOLI pepinfo swissprot:UNG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UNG_ECOLI pepnet swissprot:UNG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UNG_ECOLI pepstats swissprot:UNG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UNG_ECOLI pepwheel swissprot:UNG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UNG_ECOLI pepwindow swissprot:UNG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UNG_ECOLI sigcleave swissprot:UNG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UNG_ECOLI ## Database ID URL or Descriptions # AltName GSPE_ECOLI Putative general secretion pathway protein E # AltName GSPE_ECOLI Type II traffic warden ATPase # BioGrid 4261298 330 # EcoGene EG12891 gspE # FUNCTION GSPE_ECOLI Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. {ECO 0000305}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_component GO:0015627 type II protein secretion system complex; IEA:InterPro. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0008565 protein transporter activity; IEA:InterPro. # GO_process GO:0015628 protein secretion by the type II secretion system; IEA:InterPro. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0043234 protein complex # GOslim_function GO:0008565 protein transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0055085 transmembrane transport # Gene3D 3.40.50.300 -; 1. # INDUCTION Silenced by the DNA-binding protein H-NS under standard growth conditions. {ECO:0000269|PubMed 11118204}. # INTERACTION GSPE_ECOLI P60422 rplB; NbExp=2; IntAct=EBI-1132437, EBI-543515; # InterPro IPR001482 T2SS_protein-E # InterPro IPR003593 AAA+_ATPase # InterPro IPR013369 T2SS_GspE # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02044 M00331 Type II general secretion system # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko03070 Bacterial secretion system # MISCELLANEOUS GSPE_ECOLI Part of a cryptic operon that encodes proteins involved in type II secretion machinery in other organisms, but is not expressed in strain K12. # Organism GSPE_ECOLI Escherichia coli (strain K12) # PATRIC 32122084 VBIEscCol129921_3419 # PIR A65126 A65126 # PROSITE PS00662 T2SP_E # Pfam PF00437 T2SSE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GSPE_ECOLI Putative type II secretion system protein E # RefSeq NP_417785 NC_000913.3 # RefSeq WP_001219894 NZ_LN832404.1 # SIMILARITY Belongs to the GSP E family. {ECO 0000305}. # SMART SM00382 AAA # SUBCELLULAR LOCATION GSPE_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR02533 type_II_gspE # eggNOG COG2804 LUCA # eggNOG ENOG4107QHF Bacteria BLAST swissprot:GSPE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GSPE_ECOLI BioCyc ECOL316407:JW3288-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3288-MONOMER BioCyc EcoCyc:G7704-MONOMER http://biocyc.org/getid?id=EcoCyc:G7704-MONOMER BioCyc MetaCyc:G7704-MONOMER http://biocyc.org/getid?id=MetaCyc:G7704-MONOMER COG COG2804 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2804 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/emboj/19.24.6697 http://dx.doi.org/10.1093/emboj/19.24.6697 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2728 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2728 EcoGene EG12891 http://www.ecogene.org/geneInfo.php?eg_id=EG12891 EnsemblBacteria AAC76351 http://www.ensemblgenomes.org/id/AAC76351 EnsemblBacteria AAC76351 http://www.ensemblgenomes.org/id/AAC76351 EnsemblBacteria BAE77965 http://www.ensemblgenomes.org/id/BAE77965 EnsemblBacteria BAE77965 http://www.ensemblgenomes.org/id/BAE77965 EnsemblBacteria BAE77965 http://www.ensemblgenomes.org/id/BAE77965 EnsemblBacteria b3326 http://www.ensemblgenomes.org/id/b3326 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0015627 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015627 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GO_process GO:0015628 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015628 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947823 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947823 HOGENOM HOG000008427 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000008427&db=HOGENOM6 InParanoid P45759 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45759 IntAct P45759 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45759* InterPro IPR001482 http://www.ebi.ac.uk/interpro/entry/IPR001482 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR013369 http://www.ebi.ac.uk/interpro/entry/IPR013369 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW3288 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3288 KEGG_Gene eco:b3326 http://www.genome.jp/dbget-bin/www_bget?eco:b3326 KEGG_Orthology KO:K02454 http://www.genome.jp/dbget-bin/www_bget?KO:K02454 KEGG_Pathway ko03070 http://www.genome.jp/kegg-bin/show_pathway?ko03070 OMA NGHERNI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NGHERNI PROSITE PS00662 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00662 PSORT swissprot:GSPE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GSPE_ECOLI PSORT-B swissprot:GSPE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GSPE_ECOLI PSORT2 swissprot:GSPE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GSPE_ECOLI Pfam PF00437 http://pfam.xfam.org/family/PF00437 Phobius swissprot:GSPE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GSPE_ECOLI PhylomeDB P45759 http://phylomedb.org/?seqid=P45759 ProteinModelPortal P45759 http://www.proteinmodelportal.org/query/uniprot/P45759 PubMed 11118204 http://www.ncbi.nlm.nih.gov/pubmed/11118204 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8655552 http://www.ncbi.nlm.nih.gov/pubmed/8655552 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417785 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417785 RefSeq WP_001219894 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001219894 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P45759 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45759 STRING 511145.b3326 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3326&targetmode=cogs STRING COG2804 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2804&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR02533 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02533 UniProtKB GSPE_ECOLI http://www.uniprot.org/uniprot/GSPE_ECOLI UniProtKB-AC P45759 http://www.uniprot.org/uniprot/P45759 charge swissprot:GSPE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GSPE_ECOLI eggNOG COG2804 http://eggnogapi.embl.de/nog_data/html/tree/COG2804 eggNOG ENOG4107QHF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QHF epestfind swissprot:GSPE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GSPE_ECOLI garnier swissprot:GSPE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GSPE_ECOLI helixturnhelix swissprot:GSPE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GSPE_ECOLI hmoment swissprot:GSPE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GSPE_ECOLI iep swissprot:GSPE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GSPE_ECOLI inforesidue swissprot:GSPE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GSPE_ECOLI octanol swissprot:GSPE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GSPE_ECOLI pepcoil swissprot:GSPE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GSPE_ECOLI pepdigest swissprot:GSPE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GSPE_ECOLI pepinfo swissprot:GSPE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GSPE_ECOLI pepnet swissprot:GSPE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GSPE_ECOLI pepstats swissprot:GSPE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GSPE_ECOLI pepwheel swissprot:GSPE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GSPE_ECOLI pepwindow swissprot:GSPE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GSPE_ECOLI sigcleave swissprot:GSPE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GSPE_ECOLI ## Database ID URL or Descriptions # BioGrid 4262244 9 # COFACTOR FLHC_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000305}; Note=Binds 1 zinc ion per subunit. {ECO 0000305}; # EcoGene EG10319 flhC # FUNCTION FLHC_ECOLI Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways. {ECO 0000269|PubMed 11169100, ECO 0000269|PubMed 15941987, ECO 0000269|PubMed 7961507}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008270 zinc ion binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006351 transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0044781 bacterial-type flagellum organization; IEA:UniProtKB-KW. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IMP:EcoCyc. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:1902208 regulation of bacterial-type flagellum assembly; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # HAMAP MF_01891 FhlC # INDUCTION FLHC_ECOLI Expression is regulated by a large number of systems, including induction by quorum sensing via the two-component regulatory system QseB/QseC, induction by cAMP-CRP, repression by high osmolarity via OmpR and repression by H-NS. {ECO 0000269|PubMed 10601207, ECO 0000269|PubMed 11929534, ECO 0000269|PubMed 7642497}. # InterPro IPR007944 FlhC # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Pathway ko02020 Two-component system # KEGG_Pathway ko02040 Flagellar assembly # Organism FLHC_ECOLI Escherichia coli (strain K12) # PATRIC 32119109 VBIEscCol129921_1972 # PDB 2AVU X-ray; 3.00 A; E/F=1-192 # PIR C64952 XMECIF # PIRSF PIRSF003159 FlhC # Pfam PF05280 FlhC # ProDom PD016592 FlhC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FLHC_ECOLI Flagellar transcriptional regulator FlhC # RefSeq NP_416405 NC_000913.3 # RefSeq WP_001291603 NZ_LN832404.1 # SIMILARITY Belongs to the FlhC family. {ECO 0000305}. # SUBCELLULAR LOCATION FLHC_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Heterohexamer composed of two FlhC and four FlhD subunits. Each FlhC binds a FlhD dimer, forming a heterotrimer, and a hexamer assembles by dimerization of two heterotrimers. {ECO:0000269|PubMed 16337229}. # eggNOG ENOG4106CIA Bacteria # eggNOG ENOG410XXBZ LUCA BLAST swissprot:FLHC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLHC_ECOLI BioCyc ECOL316407:JW1880-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1880-MONOMER BioCyc EcoCyc:MONOMER0-2488 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2488 DIP DIP-9645N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9645N DOI 10.1016/j.jmb.2005.11.020 http://dx.doi.org/10.1016/j.jmb.2005.11.020 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2001.02248.x http://dx.doi.org/10.1046/j.1365-2958.2001.02248.x DOI 10.1046/j.1365-2958.2002.02803.x http://dx.doi.org/10.1046/j.1365-2958.2002.02803.x DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1099/mic.0.27879-0 http://dx.doi.org/10.1099/mic.0.27879-0 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M19439 http://www.ebi.ac.uk/ena/data/view/M19439 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0315 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0315 EcoGene EG10319 http://www.ecogene.org/geneInfo.php?eg_id=EG10319 EnsemblBacteria AAC74961 http://www.ensemblgenomes.org/id/AAC74961 EnsemblBacteria AAC74961 http://www.ensemblgenomes.org/id/AAC74961 EnsemblBacteria BAA15712 http://www.ensemblgenomes.org/id/BAA15712 EnsemblBacteria BAA15712 http://www.ensemblgenomes.org/id/BAA15712 EnsemblBacteria BAA15712 http://www.ensemblgenomes.org/id/BAA15712 EnsemblBacteria b1891 http://www.ensemblgenomes.org/id/b1891 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0044781 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044781 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GO_process GO:1902208 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902208 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 947280 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947280 HAMAP MF_01891 http://hamap.expasy.org/unirule/MF_01891 HOGENOM HOG000254687 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000254687&db=HOGENOM6 InterPro IPR007944 http://www.ebi.ac.uk/interpro/entry/IPR007944 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW1880 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1880 KEGG_Gene eco:b1891 http://www.genome.jp/dbget-bin/www_bget?eco:b1891 KEGG_Orthology KO:K02402 http://www.genome.jp/dbget-bin/www_bget?KO:K02402 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 KEGG_Pathway ko02040 http://www.genome.jp/kegg-bin/show_pathway?ko02040 OMA MLQLSAC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MLQLSAC PDB 2AVU http://www.ebi.ac.uk/pdbe-srv/view/entry/2AVU PDBsum 2AVU http://www.ebi.ac.uk/pdbsum/2AVU PSORT swissprot:FLHC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLHC_ECOLI PSORT-B swissprot:FLHC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLHC_ECOLI PSORT2 swissprot:FLHC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLHC_ECOLI Pfam PF05280 http://pfam.xfam.org/family/PF05280 Phobius swissprot:FLHC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLHC_ECOLI ProteinModelPortal P0ABY7 http://www.proteinmodelportal.org/query/uniprot/P0ABY7 PubMed 10601207 http://www.ncbi.nlm.nih.gov/pubmed/10601207 PubMed 11169100 http://www.ncbi.nlm.nih.gov/pubmed/11169100 PubMed 11929534 http://www.ncbi.nlm.nih.gov/pubmed/11929534 PubMed 15941987 http://www.ncbi.nlm.nih.gov/pubmed/15941987 PubMed 16337229 http://www.ncbi.nlm.nih.gov/pubmed/16337229 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2832369 http://www.ncbi.nlm.nih.gov/pubmed/2832369 PubMed 7642497 http://www.ncbi.nlm.nih.gov/pubmed/7642497 PubMed 7961507 http://www.ncbi.nlm.nih.gov/pubmed/7961507 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416405 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416405 RefSeq WP_001291603 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001291603 SMR P0ABY7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABY7 STRING 511145.b1891 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1891&targetmode=cogs UniProtKB FLHC_ECOLI http://www.uniprot.org/uniprot/FLHC_ECOLI UniProtKB-AC P0ABY7 http://www.uniprot.org/uniprot/P0ABY7 charge swissprot:FLHC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLHC_ECOLI eggNOG ENOG4106CIA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106CIA eggNOG ENOG410XXBZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XXBZ epestfind swissprot:FLHC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLHC_ECOLI garnier swissprot:FLHC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLHC_ECOLI helixturnhelix swissprot:FLHC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLHC_ECOLI hmoment swissprot:FLHC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLHC_ECOLI iep swissprot:FLHC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLHC_ECOLI inforesidue swissprot:FLHC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLHC_ECOLI octanol swissprot:FLHC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLHC_ECOLI pepcoil swissprot:FLHC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLHC_ECOLI pepdigest swissprot:FLHC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLHC_ECOLI pepinfo swissprot:FLHC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLHC_ECOLI pepnet swissprot:FLHC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLHC_ECOLI pepstats swissprot:FLHC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLHC_ECOLI pepwheel swissprot:FLHC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLHC_ECOLI pepwindow swissprot:FLHC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLHC_ECOLI sigcleave swissprot:FLHC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLHC_ECOLI ## Database ID URL or Descriptions # BioGrid 4262399 186 # EcoGene EG12955 aer # FUNCTION AER_ECOLI Signal transducer for aerotaxis. The aerotactic response is the accumulation of cells around air bubbles. The nature of the sensory stimulus detected by this protein is the proton motive force or cellular redox state. It uses a FAD prosthetic group as a redox sensor to monitor oxygen levels. {ECO 0000269|PubMed 9190831, ECO 0000269|PubMed 9380671}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0004871 signal transducer activity; IMP:EcoCyc. # GO_process GO:0007165 signal transduction; IMP:EcoCyc. # GO_process GO:0052131 positive aerotaxis; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0004871 signal transducer activity # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0040011 locomotion # INTERACTION AER_ECOLI Self; NbExp=4; IntAct=EBI-1130981, EBI-1130981; # IntAct P50466 4 # InterPro IPR000014 PAS # InterPro IPR001610 PAC # InterPro IPR003660 HAMP_dom # InterPro IPR004089 MCPsignal_dom # InterPro IPR004090 Chemotax_Me-accpt_rcpt # InterPro IPR013655 PAS_fold_3 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Pathway ko02020 Two-component system # KEGG_Pathway ko02030 Bacterial chemotaxis # Organism AER_ECOLI Escherichia coli (strain K12) # PATRIC 32121560 VBIEscCol129921_3166 # PIR E65095 E65095 # PRINTS PR00260 CHEMTRNSDUCR # PROSITE PS50111 CHEMOTAXIS_TRANSDUC_2 # Pfam PF00015 MCPsignal # Pfam PF00672 HAMP # Pfam PF08447 PAS_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AER_ECOLI Aerotaxis receptor # RefSeq NP_417543 NC_000913.3 # RefSeq WP_000094721 NZ_LN832404.1 # SIMILARITY Contains 1 PAC (PAS-associated C-terminal) domain. {ECO 0000305}. # SIMILARITY Contains 1 PAS (PER-ARNT-SIM) domain. {ECO 0000305}. # SIMILARITY Contains 1 methyl-accepting transducer domain. {ECO:0000255|PROSITE-ProRule PRU00284}. # SMART SM00086 PAC # SMART SM00283 MA # SUBCELLULAR LOCATION AER_ECOLI Cell inner membrane {ECO 0000269|PubMed 22380631}; Multi-pass membrane protein {ECO 0000269|PubMed 22380631}. Note=Predominantly localized to one cell pole in mid-to-late exponential phase, with a few smaller foci elsewhere in the cell. # SUPFAM SSF55785 SSF55785 # TIGRFAMs TIGR00229 sensory_box # eggNOG COG0840 LUCA # eggNOG COG2202 LUCA # eggNOG ENOG4107RHT Bacteria BLAST swissprot:AER_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AER_ECOLI BioCyc ECOL316407:JW3043-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3043-MONOMER BioCyc EcoCyc:G7595-MONOMER http://biocyc.org/getid?id=EcoCyc:G7595-MONOMER COG COG0840 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0840 COG COG2202 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2202 DIP DIP-9061N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9061N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.94.20.10541 http://dx.doi.org/10.1073/pnas.94.20.10541 DOI 10.1111/j.1365-2958.2012.08021.x http://dx.doi.org/10.1111/j.1365-2958.2012.08021.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28379 http://www.ebi.ac.uk/ena/data/view/U28379 EchoBASE EB2789 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2789 EcoGene EG12955 http://www.ecogene.org/geneInfo.php?eg_id=EG12955 EnsemblBacteria AAC76107 http://www.ensemblgenomes.org/id/AAC76107 EnsemblBacteria AAC76107 http://www.ensemblgenomes.org/id/AAC76107 EnsemblBacteria BAE77122 http://www.ensemblgenomes.org/id/BAE77122 EnsemblBacteria BAE77122 http://www.ensemblgenomes.org/id/BAE77122 EnsemblBacteria BAE77122 http://www.ensemblgenomes.org/id/BAE77122 EnsemblBacteria b3072 http://www.ensemblgenomes.org/id/b3072 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GO_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GO_process GO:0052131 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052131 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0040011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011 GeneID 945301 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945301 HOGENOM HOG000148074 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000148074&db=HOGENOM6 InParanoid P50466 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P50466 IntAct P50466 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P50466* InterPro IPR000014 http://www.ebi.ac.uk/interpro/entry/IPR000014 InterPro IPR001610 http://www.ebi.ac.uk/interpro/entry/IPR001610 InterPro IPR003660 http://www.ebi.ac.uk/interpro/entry/IPR003660 InterPro IPR004089 http://www.ebi.ac.uk/interpro/entry/IPR004089 InterPro IPR004090 http://www.ebi.ac.uk/interpro/entry/IPR004090 InterPro IPR013655 http://www.ebi.ac.uk/interpro/entry/IPR013655 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW3043 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3043 KEGG_Gene eco:b3072 http://www.genome.jp/dbget-bin/www_bget?eco:b3072 KEGG_Orthology KO:K03776 http://www.genome.jp/dbget-bin/www_bget?KO:K03776 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 KEGG_Pathway ko02030 http://www.genome.jp/kegg-bin/show_pathway?ko02030 OMA ADSYITY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ADSYITY PRINTS PR00260 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00260 PROSITE PS50111 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50111 PSORT swissprot:AER_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AER_ECOLI PSORT-B swissprot:AER_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AER_ECOLI PSORT2 swissprot:AER_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AER_ECOLI Pfam PF00015 http://pfam.xfam.org/family/PF00015 Pfam PF00672 http://pfam.xfam.org/family/PF00672 Pfam PF08447 http://pfam.xfam.org/family/PF08447 Phobius swissprot:AER_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AER_ECOLI PhylomeDB P50466 http://phylomedb.org/?seqid=P50466 ProteinModelPortal P50466 http://www.proteinmodelportal.org/query/uniprot/P50466 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22380631 http://www.ncbi.nlm.nih.gov/pubmed/22380631 PubMed 9190831 http://www.ncbi.nlm.nih.gov/pubmed/9190831 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9380671 http://www.ncbi.nlm.nih.gov/pubmed/9380671 RefSeq NP_417543 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417543 RefSeq WP_000094721 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000094721 SMART SM00086 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00086 SMART SM00283 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00283 SMR P50466 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P50466 STRING 511145.b3072 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3072&targetmode=cogs STRING COG0840 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0840&targetmode=cogs STRING COG2202 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2202&targetmode=cogs SUPFAM SSF55785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55785 TIGRFAMs TIGR00229 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00229 UniProtKB AER_ECOLI http://www.uniprot.org/uniprot/AER_ECOLI UniProtKB-AC P50466 http://www.uniprot.org/uniprot/P50466 charge swissprot:AER_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AER_ECOLI eggNOG COG0840 http://eggnogapi.embl.de/nog_data/html/tree/COG0840 eggNOG COG2202 http://eggnogapi.embl.de/nog_data/html/tree/COG2202 eggNOG ENOG4107RHT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107RHT epestfind swissprot:AER_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AER_ECOLI garnier swissprot:AER_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AER_ECOLI helixturnhelix swissprot:AER_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AER_ECOLI hmoment swissprot:AER_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AER_ECOLI iep swissprot:AER_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AER_ECOLI inforesidue swissprot:AER_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AER_ECOLI octanol swissprot:AER_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AER_ECOLI pepcoil swissprot:AER_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AER_ECOLI pepdigest swissprot:AER_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AER_ECOLI pepinfo swissprot:AER_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AER_ECOLI pepnet swissprot:AER_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AER_ECOLI pepstats swissprot:AER_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AER_ECOLI pepwheel swissprot:AER_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AER_ECOLI pepwindow swissprot:AER_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AER_ECOLI sigcleave swissprot:AER_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AER_ECOLI ## Database ID URL or Descriptions # BioGrid 4262482 9 # CATALYTIC ACTIVITY FRLD_ECOLI ATP + fructoselysine = ADP + fructoselysine 6- phosphate. # EcoGene EG12912 frlD # FUNCTION FRLD_ECOLI Phosphorylates fructoselysine to yield fructoselysine 6- phosphate. {ECO 0000269|PubMed 12147680}. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016301 kinase activity; IDA:EcoCyc. # GO_function GO:0016773 phosphotransferase activity, alcohol group as acceptor; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.1190.20 -; 1. # INTERACTION FRLD_ECOLI P0AG07 rpe; NbExp=4; IntAct=EBI-562037, EBI-546020; P05704 trg; NbExp=5; IntAct=EBI-562037, EBI-557436; # IntAct P45543 9 # InterPro IPR002173 Carboh/pur_kinase_PfkB_CS # InterPro IPR011611 PfkB_dom # InterPro IPR029056 Ribokinase-like # KEGG_Brite ko01000 Enzymes # Organism FRLD_ECOLI Escherichia coli (strain K12) # PATHWAY Carbohydrate metabolism; fructoselysine degradation; D- glucose 6-phosphate and lysine from fructoselysine step 1/2. # PATRIC 32122180 VBIEscCol129921_3467 # PIR A65132 A65132 # PROSITE PS00583 PFKB_KINASES_1 # PROSITE PS00584 PFKB_KINASES_2 # Pfam PF00294 PfkB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FRLD_ECOLI Fructoselysine kinase # RefSeq NP_417833 NC_000913.3 # RefSeq WP_000853353 NZ_LN832404.1 # SIMILARITY Belongs to the carbohydrate kinase PfkB family. {ECO 0000305}. # SUBUNIT FRLD_ECOLI Monomer. # SUPFAM SSF53613 SSF53613 # UniPathway UPA00784 UER00769 # eggNOG COG0524 LUCA # eggNOG ENOG4108KPW Bacteria BLAST swissprot:FRLD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FRLD_ECOLI BioCyc ECOL316407:JW3337-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3337-MONOMER BioCyc EcoCyc:G7726-MONOMER http://biocyc.org/getid?id=EcoCyc:G7726-MONOMER BioCyc MetaCyc:G7726-MONOMER http://biocyc.org/getid?id=MetaCyc:G7726-MONOMER COG COG0524 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0524 DIP DIP-12326N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12326N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M200863200 http://dx.doi.org/10.1074/jbc.M200863200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 2.7.1.- http://enzyme.expasy.org/EC/2.7.1.- EchoBASE EB2748 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2748 EcoGene EG12912 http://www.ecogene.org/geneInfo.php?eg_id=EG12912 EnsemblBacteria AAC76399 http://www.ensemblgenomes.org/id/AAC76399 EnsemblBacteria AAC76399 http://www.ensemblgenomes.org/id/AAC76399 EnsemblBacteria BAE77917 http://www.ensemblgenomes.org/id/BAE77917 EnsemblBacteria BAE77917 http://www.ensemblgenomes.org/id/BAE77917 EnsemblBacteria BAE77917 http://www.ensemblgenomes.org/id/BAE77917 EnsemblBacteria b3374 http://www.ensemblgenomes.org/id/b3374 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_function GO:0016773 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016773 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.1190.20 http://www.cathdb.info/version/latest/superfamily/3.40.1190.20 GeneID 947886 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947886 HOGENOM HOG000221482 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000221482&db=HOGENOM6 InParanoid P45543 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45543 IntAct P45543 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45543* IntEnz 2.7.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1 InterPro IPR002173 http://www.ebi.ac.uk/interpro/entry/IPR002173 InterPro IPR011611 http://www.ebi.ac.uk/interpro/entry/IPR011611 InterPro IPR029056 http://www.ebi.ac.uk/interpro/entry/IPR029056 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3337 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3337 KEGG_Gene eco:b3374 http://www.genome.jp/dbget-bin/www_bget?eco:b3374 KEGG_Orthology KO:K10710 http://www.genome.jp/dbget-bin/www_bget?KO:K10710 KEGG_Reaction rn:R08124 http://www.genome.jp/dbget-bin/www_bget?rn:R08124 OMA DYGFVSC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DYGFVSC PROSITE PS00583 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00583 PROSITE PS00584 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00584 PSORT swissprot:FRLD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FRLD_ECOLI PSORT-B swissprot:FRLD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FRLD_ECOLI PSORT2 swissprot:FRLD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FRLD_ECOLI Pfam PF00294 http://pfam.xfam.org/family/PF00294 Phobius swissprot:FRLD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FRLD_ECOLI PhylomeDB P45543 http://phylomedb.org/?seqid=P45543 ProteinModelPortal P45543 http://www.proteinmodelportal.org/query/uniprot/P45543 PubMed 12147680 http://www.ncbi.nlm.nih.gov/pubmed/12147680 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417833 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417833 RefSeq WP_000853353 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000853353 SMR P45543 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45543 STRING 511145.b3374 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3374&targetmode=cogs STRING COG0524 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0524&targetmode=cogs SUPFAM SSF53613 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53613 UniProtKB FRLD_ECOLI http://www.uniprot.org/uniprot/FRLD_ECOLI UniProtKB-AC P45543 http://www.uniprot.org/uniprot/P45543 charge swissprot:FRLD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FRLD_ECOLI eggNOG COG0524 http://eggnogapi.embl.de/nog_data/html/tree/COG0524 eggNOG ENOG4108KPW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108KPW epestfind swissprot:FRLD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FRLD_ECOLI garnier swissprot:FRLD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FRLD_ECOLI helixturnhelix swissprot:FRLD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FRLD_ECOLI hmoment swissprot:FRLD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FRLD_ECOLI iep swissprot:FRLD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FRLD_ECOLI inforesidue swissprot:FRLD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FRLD_ECOLI octanol swissprot:FRLD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FRLD_ECOLI pepcoil swissprot:FRLD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FRLD_ECOLI pepdigest swissprot:FRLD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FRLD_ECOLI pepinfo swissprot:FRLD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FRLD_ECOLI pepnet swissprot:FRLD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FRLD_ECOLI pepstats swissprot:FRLD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FRLD_ECOLI pepwheel swissprot:FRLD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FRLD_ECOLI pepwindow swissprot:FRLD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FRLD_ECOLI sigcleave swissprot:FRLD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FRLD_ECOLI ## Database ID URL or Descriptions # AltName RHO_ECOLI ATP-dependent helicase Rho # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=11 uM for ATP {ECO 0000269|PubMed:7487110}; # DOMAIN RHO_ECOLI Each subunit has two RNA-binding sites, one at the surface of the hexameric ring, and one at the center of the open ring structure, where RNA helicase activity is thought to take place. # ENZYME REGULATION ATPase activity is inhibited by bicyclomycin and dihydrobicyclomycin. {ECO:0000269|PubMed 7487110}. # EcoGene EG10845 rho # FUNCTION RHO_ECOLI Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template. RNA-dependent NTPase which utilizes all four ribonucleoside triphosphates as substrates. {ECO 0000269|PubMed 1716628, ECO 0000269|PubMed 2461932}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0003723 RNA binding; IDA:EcoCyc. # GO_function GO:0004386 helicase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008186 RNA-dependent ATPase activity; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0006353 DNA-templated transcription, termination; IDA:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0004386 helicase activity # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.50.300 -; 1. # HAMAP MF_01884 Rho # INTERACTION RHO_ECOLI Self; NbExp=3; IntAct=EBI-545468, EBI-545468; P0AES0 gss; NbExp=4; IntAct=EBI-545468, EBI-557080; P0A6X3 hfq; NbExp=4; IntAct=EBI-545468, EBI-547637; P0AFG0 nusG; NbExp=6; IntAct=EBI-545468, EBI-369628; P0AFW8 rof; NbExp=2; IntAct=EBI-545468, EBI-1114609; # IntAct P0AG30 64 # InterPro IPR000194 ATPase_F1/V1/A1_a/bsu_nucl-bd # InterPro IPR003593 AAA+_ATPase # InterPro IPR004665 Term_rho # InterPro IPR011112 Rho_N # InterPro IPR011113 Rho_RNA-bd # InterPro IPR011129 Cold_shock_prot # InterPro IPR012340 NA-bd_OB-fold # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko03021 Transcription machinery # KEGG_Pathway ko03018 RNA degradation # Organism RHO_ECOLI Escherichia coli (strain K12) # PATRIC 32123057 VBIEscCol129921_3898 # PDB 1A62 X-ray; 1.55 A; A=1-130 # PDB 1A63 NMR; -; A=1-130 # PDB 1A8V X-ray; 2.00 A; A/B=1-118 # PDB 1PV4 X-ray; 3.00 A; A/B/C/D/E/F=1-419 # PDB 1PVO X-ray; 3.00 A; A/B/C/D/E/F=1-419 # PDB 1XPO X-ray; 3.15 A; A/B/C/D/E/F=1-419 # PDB 1XPR X-ray; 3.15 A; A/B/C/D/E/F=1-419 # PDB 1XPU X-ray; 3.05 A; A/B/C/D/E/F=1-419 # PDB 2A8V X-ray; 2.40 A; A/B/C=1-118 # PDB 2HT1 X-ray; 3.51 A; A/B=1-411 # PDB 3ICE X-ray; 2.80 A; A/B/C/D/E/F=1-419 # PIR A03530 TWECR # Pfam PF00006 ATP-synt_ab # Pfam PF07497 Rho_RNA_bind # Pfam PF07498 Rho_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RHO_ECOLI Transcription termination factor Rho # RefSeq NP_418230 NC_000913.3 # RefSeq WP_001054527 NZ_LN832404.1 # SIMILARITY Belongs to the Rho family. {ECO 0000305}. # SMART SM00357 CSP # SMART SM00382 AAA # SMART SM00959 Rho_N # SUBUNIT RHO_ECOLI Homohexamer. The homohexamer assembles into an open ring structure. {ECO 0000269|PubMed 10230401, ECO 0000269|PubMed 12859904, ECO 0000269|PubMed 15642265, ECO 0000269|PubMed 19879839, ECO 0000269|PubMed 9586995}. # SUPFAM SSF50249 SSF50249 # SUPFAM SSF52540 SSF52540 # SUPFAM SSF68912 SSF68912 # TIGRFAMs TIGR00767 rho # eggNOG COG1158 LUCA # eggNOG ENOG4105C4P Bacteria BLAST swissprot:RHO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RHO_ECOLI BioCyc ECOL316407:JW3756-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3756-MONOMER BioCyc EcoCyc:EG10845-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10845-MONOMER COG COG1158 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1158 DIP DIP-35363N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35363N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/abbi.1995.0066 http://dx.doi.org/10.1006/abbi.1995.0066 DOI 10.1007/BF00228145 http://dx.doi.org/10.1007/BF00228145 DOI 10.1016/0378-1119(94)00664-E http://dx.doi.org/10.1016/0378-1119(94)00664-E DOI 10.1016/S0092-8674(03)00512-9 http://dx.doi.org/10.1016/S0092-8674(03)00512-9 DOI 10.1016/S1097-2765(00)80476-1 http://dx.doi.org/10.1016/S1097-2765(00)80476-1 DOI 10.1016/j.cell.2009.08.043 http://dx.doi.org/10.1016/j.cell.2009.08.043 DOI 10.1016/j.str.2004.10.013 http://dx.doi.org/10.1016/j.str.2004.10.013 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb0598-352 http://dx.doi.org/10.1038/nsb0598-352 DOI 10.1038/nsb0598-393 http://dx.doi.org/10.1038/nsb0598-393 DOI 10.1093/nar/11.11.3531 http://dx.doi.org/10.1093/nar/11.11.3531 DOI 10.1111/j.1365-2958.1991.tb00809.x http://dx.doi.org/10.1111/j.1365-2958.1991.tb00809.x DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.4.- http://www.genome.jp/dbget-bin/www_bget?EC:3.6.4.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01673 http://www.ebi.ac.uk/ena/data/view/J01673 EMBL L34404 http://www.ebi.ac.uk/ena/data/view/L34404 EMBL M12779 http://www.ebi.ac.uk/ena/data/view/M12779 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL S75640 http://www.ebi.ac.uk/ena/data/view/S75640 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.6.4.- http://enzyme.expasy.org/EC/3.6.4.- EchoBASE EB0838 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0838 EcoGene EG10845 http://www.ecogene.org/geneInfo.php?eg_id=EG10845 EnsemblBacteria AAC76788 http://www.ensemblgenomes.org/id/AAC76788 EnsemblBacteria AAC76788 http://www.ensemblgenomes.org/id/AAC76788 EnsemblBacteria BAE77515 http://www.ensemblgenomes.org/id/BAE77515 EnsemblBacteria BAE77515 http://www.ensemblgenomes.org/id/BAE77515 EnsemblBacteria BAE77515 http://www.ensemblgenomes.org/id/BAE77515 EnsemblBacteria b3783 http://www.ensemblgenomes.org/id/b3783 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0004386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004386 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008186 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006353 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006353 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0004386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004386 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948297 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948297 HAMAP MF_01884 http://hamap.expasy.org/unirule/MF_01884 HOGENOM HOG000076952 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000076952&db=HOGENOM6 InParanoid P0AG30 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AG30 IntAct P0AG30 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AG30* IntEnz 3.6.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.4 InterPro IPR000194 http://www.ebi.ac.uk/interpro/entry/IPR000194 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR004665 http://www.ebi.ac.uk/interpro/entry/IPR004665 InterPro IPR011112 http://www.ebi.ac.uk/interpro/entry/IPR011112 InterPro IPR011113 http://www.ebi.ac.uk/interpro/entry/IPR011113 InterPro IPR011129 http://www.ebi.ac.uk/interpro/entry/IPR011129 InterPro IPR012340 http://www.ebi.ac.uk/interpro/entry/IPR012340 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko03021 http://www.genome.jp/dbget-bin/www_bget?ko03021 KEGG_Gene ecj:JW3756 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3756 KEGG_Gene eco:b3783 http://www.genome.jp/dbget-bin/www_bget?eco:b3783 KEGG_Orthology KO:K03628 http://www.genome.jp/dbget-bin/www_bget?KO:K03628 KEGG_Pathway ko03018 http://www.genome.jp/kegg-bin/show_pathway?ko03018 MINT MINT-1222551 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1222551 OMA FLRAPDY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FLRAPDY PDB 1A62 http://www.ebi.ac.uk/pdbe-srv/view/entry/1A62 PDB 1A63 http://www.ebi.ac.uk/pdbe-srv/view/entry/1A63 PDB 1A8V http://www.ebi.ac.uk/pdbe-srv/view/entry/1A8V PDB 1PV4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1PV4 PDB 1PVO http://www.ebi.ac.uk/pdbe-srv/view/entry/1PVO PDB 1XPO http://www.ebi.ac.uk/pdbe-srv/view/entry/1XPO PDB 1XPR http://www.ebi.ac.uk/pdbe-srv/view/entry/1XPR PDB 1XPU http://www.ebi.ac.uk/pdbe-srv/view/entry/1XPU PDB 2A8V http://www.ebi.ac.uk/pdbe-srv/view/entry/2A8V PDB 2HT1 http://www.ebi.ac.uk/pdbe-srv/view/entry/2HT1 PDB 3ICE http://www.ebi.ac.uk/pdbe-srv/view/entry/3ICE PDBsum 1A62 http://www.ebi.ac.uk/pdbsum/1A62 PDBsum 1A63 http://www.ebi.ac.uk/pdbsum/1A63 PDBsum 1A8V http://www.ebi.ac.uk/pdbsum/1A8V PDBsum 1PV4 http://www.ebi.ac.uk/pdbsum/1PV4 PDBsum 1PVO http://www.ebi.ac.uk/pdbsum/1PVO PDBsum 1XPO http://www.ebi.ac.uk/pdbsum/1XPO PDBsum 1XPR http://www.ebi.ac.uk/pdbsum/1XPR PDBsum 1XPU http://www.ebi.ac.uk/pdbsum/1XPU PDBsum 2A8V http://www.ebi.ac.uk/pdbsum/2A8V PDBsum 2HT1 http://www.ebi.ac.uk/pdbsum/2HT1 PDBsum 3ICE http://www.ebi.ac.uk/pdbsum/3ICE PSORT swissprot:RHO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RHO_ECOLI PSORT-B swissprot:RHO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RHO_ECOLI PSORT2 swissprot:RHO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RHO_ECOLI Pfam PF00006 http://pfam.xfam.org/family/PF00006 Pfam PF07497 http://pfam.xfam.org/family/PF07497 Pfam PF07498 http://pfam.xfam.org/family/PF07498 Phobius swissprot:RHO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RHO_ECOLI PhylomeDB P0AG30 http://phylomedb.org/?seqid=P0AG30 ProteinModelPortal P0AG30 http://www.proteinmodelportal.org/query/uniprot/P0AG30 PubMed 10230401 http://www.ncbi.nlm.nih.gov/pubmed/10230401 PubMed 12859904 http://www.ncbi.nlm.nih.gov/pubmed/12859904 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 15642265 http://www.ncbi.nlm.nih.gov/pubmed/15642265 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1716628 http://www.ncbi.nlm.nih.gov/pubmed/1716628 PubMed 1722555 http://www.ncbi.nlm.nih.gov/pubmed/1722555 PubMed 19879839 http://www.ncbi.nlm.nih.gov/pubmed/19879839 PubMed 2423505 http://www.ncbi.nlm.nih.gov/pubmed/2423505 PubMed 2461932 http://www.ncbi.nlm.nih.gov/pubmed/2461932 PubMed 6304634 http://www.ncbi.nlm.nih.gov/pubmed/6304634 PubMed 7487110 http://www.ncbi.nlm.nih.gov/pubmed/7487110 PubMed 7828920 http://www.ncbi.nlm.nih.gov/pubmed/7828920 PubMed 9008362 http://www.ncbi.nlm.nih.gov/pubmed/9008362 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9586995 http://www.ncbi.nlm.nih.gov/pubmed/9586995 PubMed 9587002 http://www.ncbi.nlm.nih.gov/pubmed/9587002 RefSeq NP_418230 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418230 RefSeq WP_001054527 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001054527 SMART SM00357 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00357 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMART SM00959 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00959 SMR P0AG30 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AG30 STRING 511145.b3783 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3783&targetmode=cogs STRING COG1158 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1158&targetmode=cogs SUPFAM SSF50249 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50249 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SUPFAM SSF68912 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF68912 TIGRFAMs TIGR00767 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00767 UniProtKB RHO_ECOLI http://www.uniprot.org/uniprot/RHO_ECOLI UniProtKB-AC P0AG30 http://www.uniprot.org/uniprot/P0AG30 charge swissprot:RHO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RHO_ECOLI eggNOG COG1158 http://eggnogapi.embl.de/nog_data/html/tree/COG1158 eggNOG ENOG4105C4P http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C4P epestfind swissprot:RHO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RHO_ECOLI garnier swissprot:RHO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RHO_ECOLI helixturnhelix swissprot:RHO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RHO_ECOLI hmoment swissprot:RHO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RHO_ECOLI iep swissprot:RHO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RHO_ECOLI inforesidue swissprot:RHO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RHO_ECOLI octanol swissprot:RHO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RHO_ECOLI pepcoil swissprot:RHO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RHO_ECOLI pepdigest swissprot:RHO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RHO_ECOLI pepinfo swissprot:RHO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RHO_ECOLI pepnet swissprot:RHO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RHO_ECOLI pepstats swissprot:RHO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RHO_ECOLI pepwheel swissprot:RHO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RHO_ECOLI pepwindow swissprot:RHO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RHO_ECOLI sigcleave swissprot:RHO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RHO_ECOLI ## Database ID URL or Descriptions # AltName UDP-2,3-diacylglucosamine diphosphatase {ECO:0000255|HAMAP-Rule MF_00575} # BIOPHYSICOCHEMICAL PROPERTIES LPXH_ECOLI Kinetic parameters KM=61.7 uM for UDP-2,3-bis((3R)-3-hydroxymyristoyl)-alpha-D- glucosamine {ECO 0000269|PubMed 12000770}; Vmax=17.2 umol/min/mg enzyme {ECO 0000269|PubMed 12000770}; pH dependence Optimum pH is 8.0. {ECO 0000269|PubMed 12000770}; # BRENDA 3.6.1.54 2026 # BioGrid 4262817 203 # CATALYTIC ACTIVITY LPXH_ECOLI UDP-2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)- alpha-D-glucosamine + H(2)O = 2-N,3-O-bis((3R)-3- hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + UMP. {ECO 0000255|HAMAP-Rule MF_00575, ECO 0000269|PubMed 12000770, ECO 0000269|PubMed 12000771}. # ENZYME REGULATION LPXH_ECOLI Inhibited by Triton X-100. # EcoGene EG12666 lpxH # FUNCTION LPXH_ECOLI Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP. {ECO 0000269|PubMed 12000770}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_component GO:0019897 extrinsic component of plasma membrane; EXP:EcoCyc. # GO_function GO:0008758 UDP-2,3-diacylglucosamine hydrolase activity; IDA:UniProtKB. # GO_process GO:0009245 lipid A biosynthetic process; IDA:UniProtKB. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.60.21.10 -; 2. # HAMAP MF_00575 LpxH # IntAct P43341 20 # InterPro IPR010138 UDP-diacylglucosamine_Hdrlase # InterPro IPR024654 Calcineurin-like_PHP_lpxH # InterPro IPR029052 Metallo-depent_PP-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # KEGG_Pathway ko00540 Lipopolysaccharide biosynthesis # Organism LPXH_ECOLI Escherichia coli (strain K12) # PATHWAY Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 4/6. {ECO 0000255|HAMAP- Rule:MF_00575}. # PATRIC 32116208 VBIEscCol129921_0545 # PIR C64784 C64784 # Pfam PF12850 Metallophos_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UDP-2,3-diacylglucosamine hydrolase {ECO:0000255|HAMAP-Rule MF_00575} # RefSeq NP_415057 NC_000913.3 # RefSeq WP_000212247 NZ_LN832404.1 # SIMILARITY Belongs to the LpxH family. {ECO:0000255|HAMAP- Rule MF_00575}. # SUBCELLULAR LOCATION LPXH_ECOLI Cytoplasm. # SUPFAM SSF56300 SSF56300 # TIGRFAMs TIGR01854 lipid_A_lpxH # UniPathway UPA00359 UER00480 # eggNOG COG2908 LUCA # eggNOG ENOG4105F10 Bacteria BLAST swissprot:LPXH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LPXH_ECOLI BioCyc ECOL316407:JW0513-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0513-MONOMER BioCyc EcoCyc:EG12666-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12666-MONOMER BioCyc MetaCyc:EG12666-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12666-MONOMER COG COG2908 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2908 DIP DIP-10125N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10125N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M204067200 http://dx.doi.org/10.1074/jbc.M204067200 DOI 10.1074/jbc.M204068200 http://dx.doi.org/10.1074/jbc.M204068200 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.1.54 {ECO:0000255|HAMAP-Rule:MF_00575, ECO:0000269|PubMed:12000770, ECO:0000269|PubMed:12000771} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.1.54 {ECO:0000255|HAMAP-Rule:MF_00575, ECO:0000269|PubMed:12000770, ECO:0000269|PubMed:12000771} EMBL AF311865 http://www.ebi.ac.uk/ena/data/view/AF311865 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M19657 http://www.ebi.ac.uk/ena/data/view/M19657 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 ENZYME 3.6.1.54 {ECO:0000255|HAMAP-Rule:MF_00575, ECO:0000269|PubMed:12000770, ECO:0000269|PubMed:12000771} http://enzyme.expasy.org/EC/3.6.1.54 {ECO:0000255|HAMAP-Rule:MF_00575, ECO:0000269|PubMed:12000770, ECO:0000269|PubMed:12000771} EchoBASE EB2532 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2532 EcoGene EG12666 http://www.ecogene.org/geneInfo.php?eg_id=EG12666 EnsemblBacteria AAC73626 http://www.ensemblgenomes.org/id/AAC73626 EnsemblBacteria AAC73626 http://www.ensemblgenomes.org/id/AAC73626 EnsemblBacteria BAE76301 http://www.ensemblgenomes.org/id/BAE76301 EnsemblBacteria BAE76301 http://www.ensemblgenomes.org/id/BAE76301 EnsemblBacteria BAE76301 http://www.ensemblgenomes.org/id/BAE76301 EnsemblBacteria b0524 http://www.ensemblgenomes.org/id/b0524 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0019897 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019897 GO_function GO:0008758 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008758 GO_process GO:0009245 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009245 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.60.21.10 http://www.cathdb.info/version/latest/superfamily/3.60.21.10 GeneID 949053 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949053 HAMAP MF_00575 http://hamap.expasy.org/unirule/MF_00575 HOGENOM HOG000261930 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261930&db=HOGENOM6 InParanoid P43341 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P43341 IntAct P43341 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P43341* IntEnz 3.6.1.54 {ECO:0000255|HAMAP-Rule:MF_00575, ECO:0000269|PubMed:12000770, ECO:0000269|PubMed:12000771} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.1.54 {ECO:0000255|HAMAP-Rule:MF_00575, ECO:0000269|PubMed:12000770, ECO:0000269|PubMed:12000771} InterPro IPR010138 http://www.ebi.ac.uk/interpro/entry/IPR010138 InterPro IPR024654 http://www.ebi.ac.uk/interpro/entry/IPR024654 InterPro IPR029052 http://www.ebi.ac.uk/interpro/entry/IPR029052 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Gene ecj:JW0513 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0513 KEGG_Gene eco:b0524 http://www.genome.jp/dbget-bin/www_bget?eco:b0524 KEGG_Orthology KO:K03269 http://www.genome.jp/dbget-bin/www_bget?KO:K03269 KEGG_Pathway ko00540 http://www.genome.jp/kegg-bin/show_pathway?ko00540 KEGG_Reaction rn:R04549 http://www.genome.jp/dbget-bin/www_bget?rn:R04549 OMA FMHGNRD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FMHGNRD PSORT swissprot:LPXH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LPXH_ECOLI PSORT-B swissprot:LPXH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LPXH_ECOLI PSORT2 swissprot:LPXH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LPXH_ECOLI Pfam PF12850 http://pfam.xfam.org/family/PF12850 Phobius swissprot:LPXH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LPXH_ECOLI PhylomeDB P43341 http://phylomedb.org/?seqid=P43341 ProteinModelPortal P43341 http://www.proteinmodelportal.org/query/uniprot/P43341 PubMed 12000770 http://www.ncbi.nlm.nih.gov/pubmed/12000770 PubMed 12000771 http://www.ncbi.nlm.nih.gov/pubmed/12000771 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2644189 http://www.ncbi.nlm.nih.gov/pubmed/2644189 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415057 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415057 RefSeq WP_000212247 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000212247 SMR P43341 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P43341 STRING 511145.b0524 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0524&targetmode=cogs STRING COG2908 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2908&targetmode=cogs SUPFAM SSF56300 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56300 TIGRFAMs TIGR01854 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01854 UniProtKB LPXH_ECOLI http://www.uniprot.org/uniprot/LPXH_ECOLI UniProtKB-AC P43341 http://www.uniprot.org/uniprot/P43341 charge swissprot:LPXH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LPXH_ECOLI eggNOG COG2908 http://eggnogapi.embl.de/nog_data/html/tree/COG2908 eggNOG ENOG4105F10 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F10 epestfind swissprot:LPXH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LPXH_ECOLI garnier swissprot:LPXH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LPXH_ECOLI helixturnhelix swissprot:LPXH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LPXH_ECOLI hmoment swissprot:LPXH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LPXH_ECOLI iep swissprot:LPXH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LPXH_ECOLI inforesidue swissprot:LPXH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LPXH_ECOLI octanol swissprot:LPXH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LPXH_ECOLI pepcoil swissprot:LPXH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LPXH_ECOLI pepdigest swissprot:LPXH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LPXH_ECOLI pepinfo swissprot:LPXH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LPXH_ECOLI pepnet swissprot:LPXH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LPXH_ECOLI pepstats swissprot:LPXH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LPXH_ECOLI pepwheel swissprot:LPXH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LPXH_ECOLI pepwindow swissprot:LPXH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LPXH_ECOLI sigcleave swissprot:LPXH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LPXH_ECOLI ## Database ID URL or Descriptions # BioGrid 4259139 160 # COFACTOR YDJA_ECOLI Name=FMN; Xref=ChEBI CHEBI 58210; Evidence={ECO 0000269|PubMed 18241886}; Note=Binds 1 FMN per subunit. {ECO 0000269|PubMed 18241886}; # EcoGene EG11134 ydjA # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0010181 FMN binding; IDA:EcoCyc. # GO_function GO:0016491 oxidoreductase activity; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.109.10 -; 1. # IntAct P0ACY1 11 # InterPro IPR000415 Nitroreductase-like # InterPro IPR026021 YdjA-like # InterPro IPR029479 Nitroreductase # Organism YDJA_ECOLI Escherichia coli (strain K12) # PATRIC 32118841 VBIEscCol129921_1838 # PDB 3BM1 X-ray; 2.00 A; A/B=1-183 # PDB 3BM2 X-ray; 2.10 A; A/B=1-183 # PIR A40360 A40360 # PIRSF PIRSF000232 YdjA # Pfam PF00881 Nitroreductase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDJA_ECOLI Putative NAD(P)H nitroreductase YdjA # RefSeq NP_416279 NC_000913.3 # RefSeq WP_000339283 NZ_LN832404.1 # SIMILARITY Belongs to the nitroreductase family. {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 18241886}. # SUPFAM SSF55469 SSF55469 # eggNOG COG0778 LUCA # eggNOG ENOG41069NU Bacteria BLAST swissprot:YDJA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDJA_ECOLI BioCyc ECOL316407:JW1754-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1754-MONOMER BioCyc EcoCyc:EG11134-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11134-MONOMER DIP DIP-31841N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31841N DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1016/j.jmb.2008.01.004 http://dx.doi.org/10.1016/j.jmb.2008.01.004 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M68961 http://www.ebi.ac.uk/ena/data/view/M68961 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- EchoBASE EB1124 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1124 EcoGene EG11134 http://www.ecogene.org/geneInfo.php?eg_id=EG11134 EnsemblBacteria AAC74835 http://www.ensemblgenomes.org/id/AAC74835 EnsemblBacteria AAC74835 http://www.ensemblgenomes.org/id/AAC74835 EnsemblBacteria BAA15556 http://www.ensemblgenomes.org/id/BAA15556 EnsemblBacteria BAA15556 http://www.ensemblgenomes.org/id/BAA15556 EnsemblBacteria BAA15556 http://www.ensemblgenomes.org/id/BAA15556 EnsemblBacteria b1765 http://www.ensemblgenomes.org/id/b1765 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0010181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010181 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.109.10 http://www.cathdb.info/version/latest/superfamily/3.40.109.10 GeneID 945964 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945964 HOGENOM HOG000146733 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000146733&db=HOGENOM6 InParanoid P0ACY1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACY1 IntAct P0ACY1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACY1* IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR000415 http://www.ebi.ac.uk/interpro/entry/IPR000415 InterPro IPR026021 http://www.ebi.ac.uk/interpro/entry/IPR026021 InterPro IPR029479 http://www.ebi.ac.uk/interpro/entry/IPR029479 KEGG_Gene ecj:JW1754 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1754 KEGG_Gene eco:b1765 http://www.genome.jp/dbget-bin/www_bget?eco:b1765 MINT MINT-1239401 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1239401 OMA QGIGAVW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QGIGAVW PDB 3BM1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3BM1 PDB 3BM2 http://www.ebi.ac.uk/pdbe-srv/view/entry/3BM2 PDBsum 3BM1 http://www.ebi.ac.uk/pdbsum/3BM1 PDBsum 3BM2 http://www.ebi.ac.uk/pdbsum/3BM2 PSORT swissprot:YDJA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDJA_ECOLI PSORT-B swissprot:YDJA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDJA_ECOLI PSORT2 swissprot:YDJA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDJA_ECOLI Pfam PF00881 http://pfam.xfam.org/family/PF00881 Phobius swissprot:YDJA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDJA_ECOLI PhylomeDB P0ACY1 http://phylomedb.org/?seqid=P0ACY1 ProteinModelPortal P0ACY1 http://www.proteinmodelportal.org/query/uniprot/P0ACY1 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 1650339 http://www.ncbi.nlm.nih.gov/pubmed/1650339 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18241886 http://www.ncbi.nlm.nih.gov/pubmed/18241886 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416279 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416279 RefSeq WP_000339283 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000339283 SMR P0ACY1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACY1 STRING 511145.b1765 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1765&targetmode=cogs SUPFAM SSF55469 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55469 UniProtKB YDJA_ECOLI http://www.uniprot.org/uniprot/YDJA_ECOLI UniProtKB-AC P0ACY1 http://www.uniprot.org/uniprot/P0ACY1 charge swissprot:YDJA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDJA_ECOLI eggNOG COG0778 http://eggnogapi.embl.de/nog_data/html/tree/COG0778 eggNOG ENOG41069NU http://eggnogapi.embl.de/nog_data/html/tree/ENOG41069NU epestfind swissprot:YDJA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDJA_ECOLI garnier swissprot:YDJA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDJA_ECOLI helixturnhelix swissprot:YDJA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDJA_ECOLI hmoment swissprot:YDJA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDJA_ECOLI iep swissprot:YDJA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDJA_ECOLI inforesidue swissprot:YDJA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDJA_ECOLI octanol swissprot:YDJA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDJA_ECOLI pepcoil swissprot:YDJA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDJA_ECOLI pepdigest swissprot:YDJA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDJA_ECOLI pepinfo swissprot:YDJA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDJA_ECOLI pepnet swissprot:YDJA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDJA_ECOLI pepstats swissprot:YDJA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDJA_ECOLI pepwheel swissprot:YDJA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDJA_ECOLI pepwindow swissprot:YDJA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDJA_ECOLI sigcleave swissprot:YDJA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDJA_ECOLI ## Database ID URL or Descriptions # EcoGene EG11738 rsd # FUNCTION RSD_ECOLI Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase. {ECO 0000255|HAMAP-Rule MF_01181, ECO 0000269|PubMed 10368152, ECO 0000269|PubMed 9560209}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0016989 sigma factor antagonist activity; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0000988 transcription factor activity, protein binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # HAMAP MF_01181 Rsd # INTERACTION RSD_ECOLI P00579 rpoD; NbExp=11; IntAct=EBI-1134364, EBI-545104; # IntAct P0AFX4 8 # InterPro IPR007448 Sigma70_reg_Rsd_AlgQ # InterPro IPR023785 Sigma70_reg_Rsd # Organism RSD_ECOLI Escherichia coli (strain K12) # PATRIC 32123513 VBIEscCol129921_4109 # PDB 2P7V X-ray; 2.60 A; A=1-158 # PDB 4XWJ X-ray; 2.10 A; A=1-151 # PIR F65206 F65206 # PIRSF PIRSF016548 Rsd_AlgQ # Pfam PF04353 Rsd_AlgQ # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Regulator of sigma D {ECO:0000255|HAMAP-Rule MF_01181} # RefSeq NP_418423 NC_000913.3 # RefSeq WP_000934302 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=D12624; Type=Frameshift; Positions=137; Evidence={ECO 0000305}; # SIMILARITY Belongs to the Rsd/AlgQ family. {ECO:0000255|HAMAP- Rule MF_01181}. # SUBCELLULAR LOCATION RSD_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_01181}. # SUBUNIT RSD_ECOLI Interacts with RpoD. {ECO 0000255|HAMAP-Rule MF_01181, ECO 0000269|PubMed 17681541, ECO 0000269|PubMed 9560209}. # eggNOG COG3160 LUCA # eggNOG ENOG4107MNS Bacteria BLAST swissprot:RSD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RSD_ECOLI BioCyc ECOL316407:JW3959-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3959-MONOMER BioCyc EcoCyc:EG11738-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11738-MONOMER COG COG3160 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3160 DIP DIP-10800N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10800N DOI 10.1016/j.jmb.2007.06.081 http://dx.doi.org/10.1016/j.jmb.2007.06.081 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.95.9.4953 http://dx.doi.org/10.1073/pnas.95.9.4953 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D12624 http://www.ebi.ac.uk/ena/data/view/D12624 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1689 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1689 EcoGene EG11738 http://www.ecogene.org/geneInfo.php?eg_id=EG11738 EnsemblBacteria AAC76969 http://www.ensemblgenomes.org/id/AAC76969 EnsemblBacteria AAC76969 http://www.ensemblgenomes.org/id/AAC76969 EnsemblBacteria BAE77324 http://www.ensemblgenomes.org/id/BAE77324 EnsemblBacteria BAE77324 http://www.ensemblgenomes.org/id/BAE77324 EnsemblBacteria BAE77324 http://www.ensemblgenomes.org/id/BAE77324 EnsemblBacteria b3995 http://www.ensemblgenomes.org/id/b3995 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0016989 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016989 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0000988 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000988 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 948496 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948496 HAMAP MF_01181 http://hamap.expasy.org/unirule/MF_01181 HOGENOM HOG000283202 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000283202&db=HOGENOM6 InParanoid P0AFX4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFX4 IntAct P0AFX4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFX4* InterPro IPR007448 http://www.ebi.ac.uk/interpro/entry/IPR007448 InterPro IPR023785 http://www.ebi.ac.uk/interpro/entry/IPR023785 KEGG_Gene ecj:JW3959 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3959 KEGG_Gene eco:b3995 http://www.genome.jp/dbget-bin/www_bget?eco:b3995 KEGG_Orthology KO:K07740 http://www.genome.jp/dbget-bin/www_bget?KO:K07740 OMA LESCQNA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LESCQNA PDB 2P7V http://www.ebi.ac.uk/pdbe-srv/view/entry/2P7V PDB 4XWJ http://www.ebi.ac.uk/pdbe-srv/view/entry/4XWJ PDBsum 2P7V http://www.ebi.ac.uk/pdbsum/2P7V PDBsum 4XWJ http://www.ebi.ac.uk/pdbsum/4XWJ PSORT swissprot:RSD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RSD_ECOLI PSORT-B swissprot:RSD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RSD_ECOLI PSORT2 swissprot:RSD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RSD_ECOLI Pfam PF04353 http://pfam.xfam.org/family/PF04353 Phobius swissprot:RSD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RSD_ECOLI ProteinModelPortal P0AFX4 http://www.proteinmodelportal.org/query/uniprot/P0AFX4 PubMed 10368152 http://www.ncbi.nlm.nih.gov/pubmed/10368152 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17681541 http://www.ncbi.nlm.nih.gov/pubmed/17681541 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9560209 http://www.ncbi.nlm.nih.gov/pubmed/9560209 RefSeq NP_418423 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418423 RefSeq WP_000934302 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000934302 SMR P0AFX4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFX4 STRING 511145.b3995 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3995&targetmode=cogs STRING COG3160 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3160&targetmode=cogs UniProtKB RSD_ECOLI http://www.uniprot.org/uniprot/RSD_ECOLI UniProtKB-AC P0AFX4 http://www.uniprot.org/uniprot/P0AFX4 charge swissprot:RSD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RSD_ECOLI eggNOG COG3160 http://eggnogapi.embl.de/nog_data/html/tree/COG3160 eggNOG ENOG4107MNS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107MNS epestfind swissprot:RSD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RSD_ECOLI garnier swissprot:RSD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RSD_ECOLI helixturnhelix swissprot:RSD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RSD_ECOLI hmoment swissprot:RSD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RSD_ECOLI iep swissprot:RSD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RSD_ECOLI inforesidue swissprot:RSD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RSD_ECOLI octanol swissprot:RSD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RSD_ECOLI pepcoil swissprot:RSD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RSD_ECOLI pepdigest swissprot:RSD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RSD_ECOLI pepinfo swissprot:RSD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RSD_ECOLI pepnet swissprot:RSD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RSD_ECOLI pepstats swissprot:RSD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RSD_ECOLI pepwheel swissprot:RSD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RSD_ECOLI pepwindow swissprot:RSD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RSD_ECOLI sigcleave swissprot:RSD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RSD_ECOLI ## Database ID URL or Descriptions # AltName DEF_ECOLI Polypeptide deformylase # BRENDA 3.5.1.88 2026 # BioGrid 4263416 16 # CATALYTIC ACTIVITY DEF_ECOLI Formyl-L-methionyl peptide + H(2)O = formate + methionyl peptide. # CDD cd00487 Pep_deformylase # COFACTOR DEF_ECOLI Name=Fe(2+); Xref=ChEBI CHEBI 29033; Evidence={ECO 0000269|PubMed 9610360}; Note=Binds 1 Fe(2+) ion per monomer. {ECO 0000269|PubMed 9610360}; # EcoGene EG11440 def # FUNCTION DEF_ECOLI Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008198 ferrous iron binding; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IDA:EcoliWiki. # GO_function GO:0016787 hydrolase activity; IDA:EcoliWiki. # GO_function GO:0042586 peptide deformylase activity; IDA:EcoliWiki. # GO_function GO:0043022 ribosome binding; IDA:EcoCyc. # GO_process GO:0006412 translation; IEA:UniProtKB-HAMAP. # GO_process GO:0031365 N-terminal protein amino acid modification; IDA:EcoliWiki. # GO_process GO:0043686 co-translational protein modification; IPI:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006412 translation # GOslim_process GO:0006464 cellular protein modification process # Gene3D 3.90.45.10 -; 1. # HAMAP MF_00163 Pep_deformylase # IntAct P0A6K3 13 # InterPro IPR023635 Peptide_deformylase # KEGG_Brite ko01000 Enzymes # Organism DEF_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10458 PTHR10458 # PATRIC 32122006 VBIEscCol129921_3380 # PDB 1BS4 X-ray; 1.90 A; A/B/C=2-169 # PDB 1BS5 X-ray; 2.50 A; A/B/C=2-169 # PDB 1BS6 X-ray; 2.10 A; A/B/C=2-169 # PDB 1BS7 X-ray; 2.50 A; A/B/C=2-169 # PDB 1BS8 X-ray; 2.20 A; A/B/C=2-169 # PDB 1BSJ X-ray; 3.00 A; A=2-169 # PDB 1BSK X-ray; 3.00 A; A=2-169 # PDB 1BSZ X-ray; 1.90 A; A/B/C=2-169 # PDB 1DEF NMR; -; A=2-148 # PDB 1DFF X-ray; 2.88 A; A=2-165 # PDB 1DTF Model; -; A=1-169 # PDB 1G27 X-ray; 2.10 A; A/B/C=2-169 # PDB 1G2A X-ray; 1.75 A; A/B/C=2-169 # PDB 1ICJ X-ray; 1.90 A; A/B/C=2-169 # PDB 1LRU X-ray; 2.10 A; A/B/C=2-169 # PDB 1XEM X-ray; 1.76 A; A=2-169 # PDB 1XEN X-ray; 1.85 A; A=2-169 # PDB 1XEO X-ray; 1.30 A; A=2-169 # PDB 2AI8 X-ray; 1.70 A; A/B/C=2-169 # PDB 2DEF NMR; -; A=3-148 # PDB 2DTF Model; -; A=1-169 # PDB 2KMN NMR; -; A=2-148 # PDB 2W3T X-ray; 1.69 A; A=2-169 # PDB 2W3U X-ray; 1.96 A; A=2-169 # PDB 3K6L X-ray; 2.15 A; A/B/C=1-169 # PDB 4AL2 X-ray; 2.60 A; A/B/C=2-169 # PDB 4AL3 X-ray; 1.98 A; A=2-169 # PDB 4V5B X-ray; 3.74 A; A5=147-162 # PIR S23107 S23107 # PIRSF PIRSF004749 Pep_def # PRINTS PR01576 PDEFORMYLASE # Pfam PF01327 Pep_deformylase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DEF_ECOLI Peptide deformylase # RefSeq NP_417745 NC_000913.3 # RefSeq WP_000114984 NZ_LN832404.1 # SIMILARITY Belongs to the polypeptide deformylase family. {ECO 0000305}. # SUBUNIT DEF_ECOLI Monomer. # SUPFAM SSF56420 SSF56420 # TIGRFAMs TIGR00079 pept_deformyl # eggNOG COG0242 LUCA # eggNOG ENOG4108Z02 Bacteria BLAST swissprot:DEF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DEF_ECOLI BioCyc ECOL316407:JW3248-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3248-MONOMER BioCyc EcoCyc:EG11440-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11440-MONOMER BioCyc MetaCyc:EG11440-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11440-MONOMER COG COG0242 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0242 DIP DIP-47953N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47953N DOI 10.1006/bbrc.1998.8616 http://dx.doi.org/10.1006/bbrc.1998.8616 DOI 10.1006/jmbi.1996.0521 http://dx.doi.org/10.1006/jmbi.1996.0521 DOI 10.1006/jmbi.1998.1882 http://dx.doi.org/10.1006/jmbi.1998.1882 DOI 10.1021/bi9711543 http://dx.doi.org/10.1021/bi9711543 DOI 10.1021/bi982594c http://dx.doi.org/10.1021/bi982594c DOI 10.1038/4162 http://dx.doi.org/10.1038/4162 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.273.19.11413 http://dx.doi.org/10.1074/jbc.273.19.11413 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.5.1.88 http://www.genome.jp/dbget-bin/www_bget?EC:3.5.1.88 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X63666 http://www.ebi.ac.uk/ena/data/view/X63666 EMBL X65946 http://www.ebi.ac.uk/ena/data/view/X65946 EMBL X77091 http://www.ebi.ac.uk/ena/data/view/X77091 EMBL X77800 http://www.ebi.ac.uk/ena/data/view/X77800 ENZYME 3.5.1.88 http://enzyme.expasy.org/EC/3.5.1.88 EchoBASE EB1410 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1410 EcoGene EG11440 http://www.ecogene.org/geneInfo.php?eg_id=EG11440 EnsemblBacteria AAC76312 http://www.ensemblgenomes.org/id/AAC76312 EnsemblBacteria AAC76312 http://www.ensemblgenomes.org/id/AAC76312 EnsemblBacteria BAE78005 http://www.ensemblgenomes.org/id/BAE78005 EnsemblBacteria BAE78005 http://www.ensemblgenomes.org/id/BAE78005 EnsemblBacteria BAE78005 http://www.ensemblgenomes.org/id/BAE78005 EnsemblBacteria b3287 http://www.ensemblgenomes.org/id/b3287 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008198 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0016787 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016787 GO_function GO:0042586 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042586 GO_function GO:0043022 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043022 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GO_process GO:0031365 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031365 GO_process GO:0043686 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043686 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 Gene3D 3.90.45.10 http://www.cathdb.info/version/latest/superfamily/3.90.45.10 GeneID 947780 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947780 HAMAP MF_00163 http://hamap.expasy.org/unirule/MF_00163 HOGENOM HOG000243509 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000243509&db=HOGENOM6 InParanoid P0A6K3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6K3 IntAct P0A6K3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6K3* IntEnz 3.5.1.88 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.1.88 InterPro IPR023635 http://www.ebi.ac.uk/interpro/entry/IPR023635 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3248 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3248 KEGG_Gene eco:b3287 http://www.genome.jp/dbget-bin/www_bget?eco:b3287 KEGG_Orthology KO:K01462 http://www.genome.jp/dbget-bin/www_bget?KO:K01462 OMA VCIQHEI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VCIQHEI PANTHER PTHR10458 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10458 PDB 1BS4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1BS4 PDB 1BS5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1BS5 PDB 1BS6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1BS6 PDB 1BS7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1BS7 PDB 1BS8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1BS8 PDB 1BSJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1BSJ PDB 1BSK http://www.ebi.ac.uk/pdbe-srv/view/entry/1BSK PDB 1BSZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1BSZ PDB 1DEF http://www.ebi.ac.uk/pdbe-srv/view/entry/1DEF PDB 1DFF http://www.ebi.ac.uk/pdbe-srv/view/entry/1DFF PDB 1DTF http://www.ebi.ac.uk/pdbe-srv/view/entry/1DTF PDB 1G27 http://www.ebi.ac.uk/pdbe-srv/view/entry/1G27 PDB 1G2A http://www.ebi.ac.uk/pdbe-srv/view/entry/1G2A PDB 1ICJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1ICJ PDB 1LRU http://www.ebi.ac.uk/pdbe-srv/view/entry/1LRU PDB 1XEM http://www.ebi.ac.uk/pdbe-srv/view/entry/1XEM PDB 1XEN http://www.ebi.ac.uk/pdbe-srv/view/entry/1XEN PDB 1XEO http://www.ebi.ac.uk/pdbe-srv/view/entry/1XEO PDB 2AI8 http://www.ebi.ac.uk/pdbe-srv/view/entry/2AI8 PDB 2DEF http://www.ebi.ac.uk/pdbe-srv/view/entry/2DEF PDB 2DTF http://www.ebi.ac.uk/pdbe-srv/view/entry/2DTF PDB 2KMN http://www.ebi.ac.uk/pdbe-srv/view/entry/2KMN PDB 2W3T http://www.ebi.ac.uk/pdbe-srv/view/entry/2W3T PDB 2W3U http://www.ebi.ac.uk/pdbe-srv/view/entry/2W3U PDB 3K6L http://www.ebi.ac.uk/pdbe-srv/view/entry/3K6L PDB 4AL2 http://www.ebi.ac.uk/pdbe-srv/view/entry/4AL2 PDB 4AL3 http://www.ebi.ac.uk/pdbe-srv/view/entry/4AL3 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDBsum 1BS4 http://www.ebi.ac.uk/pdbsum/1BS4 PDBsum 1BS5 http://www.ebi.ac.uk/pdbsum/1BS5 PDBsum 1BS6 http://www.ebi.ac.uk/pdbsum/1BS6 PDBsum 1BS7 http://www.ebi.ac.uk/pdbsum/1BS7 PDBsum 1BS8 http://www.ebi.ac.uk/pdbsum/1BS8 PDBsum 1BSJ http://www.ebi.ac.uk/pdbsum/1BSJ PDBsum 1BSK http://www.ebi.ac.uk/pdbsum/1BSK PDBsum 1BSZ http://www.ebi.ac.uk/pdbsum/1BSZ PDBsum 1DEF http://www.ebi.ac.uk/pdbsum/1DEF PDBsum 1DFF http://www.ebi.ac.uk/pdbsum/1DFF PDBsum 1DTF http://www.ebi.ac.uk/pdbsum/1DTF PDBsum 1G27 http://www.ebi.ac.uk/pdbsum/1G27 PDBsum 1G2A http://www.ebi.ac.uk/pdbsum/1G2A PDBsum 1ICJ http://www.ebi.ac.uk/pdbsum/1ICJ PDBsum 1LRU http://www.ebi.ac.uk/pdbsum/1LRU PDBsum 1XEM http://www.ebi.ac.uk/pdbsum/1XEM PDBsum 1XEN http://www.ebi.ac.uk/pdbsum/1XEN PDBsum 1XEO http://www.ebi.ac.uk/pdbsum/1XEO PDBsum 2AI8 http://www.ebi.ac.uk/pdbsum/2AI8 PDBsum 2DEF http://www.ebi.ac.uk/pdbsum/2DEF PDBsum 2DTF http://www.ebi.ac.uk/pdbsum/2DTF PDBsum 2KMN http://www.ebi.ac.uk/pdbsum/2KMN PDBsum 2W3T http://www.ebi.ac.uk/pdbsum/2W3T PDBsum 2W3U http://www.ebi.ac.uk/pdbsum/2W3U PDBsum 3K6L http://www.ebi.ac.uk/pdbsum/3K6L PDBsum 4AL2 http://www.ebi.ac.uk/pdbsum/4AL2 PDBsum 4AL3 http://www.ebi.ac.uk/pdbsum/4AL3 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PRINTS PR01576 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01576 PSORT swissprot:DEF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DEF_ECOLI PSORT-B swissprot:DEF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DEF_ECOLI PSORT2 swissprot:DEF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DEF_ECOLI Pfam PF01327 http://pfam.xfam.org/family/PF01327 Phobius swissprot:DEF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DEF_ECOLI PhylomeDB P0A6K3 http://phylomedb.org/?seqid=P0A6K3 ProteinModelPortal P0A6K3 http://www.proteinmodelportal.org/query/uniprot/P0A6K3 PubMed 10200158 http://www.ncbi.nlm.nih.gov/pubmed/10200158 PubMed 1624424 http://www.ncbi.nlm.nih.gov/pubmed/1624424 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7896716 http://www.ncbi.nlm.nih.gov/pubmed/7896716 PubMed 8112305 http://www.ncbi.nlm.nih.gov/pubmed/8112305 PubMed 8432722 http://www.ncbi.nlm.nih.gov/pubmed/8432722 PubMed 8845003 http://www.ncbi.nlm.nih.gov/pubmed/8845003 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9374869 http://www.ncbi.nlm.nih.gov/pubmed/9374869 PubMed 9565550 http://www.ncbi.nlm.nih.gov/pubmed/9565550 PubMed 9610360 http://www.ncbi.nlm.nih.gov/pubmed/9610360 PubMed 9665852 http://www.ncbi.nlm.nih.gov/pubmed/9665852 PubMed 9846875 http://www.ncbi.nlm.nih.gov/pubmed/9846875 RefSeq NP_417745 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417745 RefSeq WP_000114984 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000114984 SMR P0A6K3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6K3 STRING 511145.b3287 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3287&targetmode=cogs STRING COG0242 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0242&targetmode=cogs SUPFAM SSF56420 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56420 TIGRFAMs TIGR00079 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00079 UniProtKB DEF_ECOLI http://www.uniprot.org/uniprot/DEF_ECOLI UniProtKB-AC P0A6K3 http://www.uniprot.org/uniprot/P0A6K3 charge swissprot:DEF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DEF_ECOLI eggNOG COG0242 http://eggnogapi.embl.de/nog_data/html/tree/COG0242 eggNOG ENOG4108Z02 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Z02 epestfind swissprot:DEF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DEF_ECOLI garnier swissprot:DEF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DEF_ECOLI helixturnhelix swissprot:DEF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DEF_ECOLI hmoment swissprot:DEF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DEF_ECOLI iep swissprot:DEF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DEF_ECOLI inforesidue swissprot:DEF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DEF_ECOLI octanol swissprot:DEF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DEF_ECOLI pepcoil swissprot:DEF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DEF_ECOLI pepdigest swissprot:DEF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DEF_ECOLI pepinfo swissprot:DEF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DEF_ECOLI pepnet swissprot:DEF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DEF_ECOLI pepstats swissprot:DEF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DEF_ECOLI pepwheel swissprot:DEF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DEF_ECOLI pepwindow swissprot:DEF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DEF_ECOLI sigcleave swissprot:DEF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DEF_ECOLI ## Database ID URL or Descriptions # BioGrid 4259118 6 # EcoGene EG13848 clcB # FUNCTION CLCB_ECOLI Probably acts as an electrical shunt for an outwardly- directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response. {ECO 0000269|PubMed 12384697}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0034707 chloride channel complex; IEA:UniProtKB-KW. # GO_function GO:0005247 voltage-gated chloride channel activity; IBA:GO_Central. # GO_function GO:0031404 chloride ion binding; IBA:GO_Central. # GO_process GO:0010447 response to acidic pH; IEA:InterPro. # GO_process GO:1902476 chloride transmembrane transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0055085 transmembrane transport # Gene3D 1.10.3080.10 -; 1. # HAMAP MF_01203 CLC_ClcB # InterPro IPR001807 Cl-channel_volt-gated # InterPro IPR014743 Cl-channel_core # InterPro IPR023790 Cl-channel_volt-gated_ClcB # Organism CLCB_ECOLI Escherichia coli (strain K12) # PATRIC 32118486 VBIEscCol129921_1663 # PIR B64915 B64915 # PRINTS PR00762 CLCHANNEL # Pfam PF00654 Voltage_CLC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CLCB_ECOLI Voltage-gated ClC-type chloride channel ClcB # RefSeq NP_416109 NC_000913.3 # RefSeq WP_001350514 NZ_LN832404.1 # SIMILARITY Belongs to the chloride channel (TC 2.A.49) family. ClcB subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION CLCB_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF81340 SSF81340 # eggNOG COG0038 LUCA # eggNOG ENOG4105CMQ Bacteria BLAST swissprot:CLCB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CLCB_ECOLI BioCyc ECOL316407:JW5263-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5263-MONOMER BioCyc EcoCyc:YNFJ-MONOMER http://biocyc.org/getid?id=EcoCyc:YNFJ-MONOMER COG COG0038 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0038 DIP DIP-28065N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-28065N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature01000 http://dx.doi.org/10.1038/nature01000 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3609 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3609 EcoGene EG13848 http://www.ecogene.org/geneInfo.php?eg_id=EG13848 EnsemblBacteria AAC74664 http://www.ensemblgenomes.org/id/AAC74664 EnsemblBacteria AAC74664 http://www.ensemblgenomes.org/id/AAC74664 EnsemblBacteria BAA15316 http://www.ensemblgenomes.org/id/BAA15316 EnsemblBacteria BAA15316 http://www.ensemblgenomes.org/id/BAA15316 EnsemblBacteria BAA15316 http://www.ensemblgenomes.org/id/BAA15316 EnsemblBacteria b1592 http://www.ensemblgenomes.org/id/b1592 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0034707 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034707 GO_function GO:0005247 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005247 GO_function GO:0031404 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031404 GO_process GO:0010447 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010447 GO_process GO:1902476 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902476 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 1.10.3080.10 http://www.cathdb.info/version/latest/superfamily/1.10.3080.10 GeneID 947179 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947179 HAMAP MF_01203 http://hamap.expasy.org/unirule/MF_01203 HOGENOM HOG000230177 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230177&db=HOGENOM6 InParanoid P76175 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76175 IntAct P76175 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76175* InterPro IPR001807 http://www.ebi.ac.uk/interpro/entry/IPR001807 InterPro IPR014743 http://www.ebi.ac.uk/interpro/entry/IPR014743 InterPro IPR023790 http://www.ebi.ac.uk/interpro/entry/IPR023790 KEGG_Gene ecj:JW5263 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5263 KEGG_Gene eco:b1592 http://www.genome.jp/dbget-bin/www_bget?eco:b1592 KEGG_Orthology KO:K03281 http://www.genome.jp/dbget-bin/www_bget?KO:K03281 OMA PWYVRFW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PWYVRFW PRINTS PR00762 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00762 PSORT swissprot:CLCB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CLCB_ECOLI PSORT-B swissprot:CLCB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CLCB_ECOLI PSORT2 swissprot:CLCB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CLCB_ECOLI Pfam PF00654 http://pfam.xfam.org/family/PF00654 Phobius swissprot:CLCB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CLCB_ECOLI PhylomeDB P76175 http://phylomedb.org/?seqid=P76175 ProteinModelPortal P76175 http://www.proteinmodelportal.org/query/uniprot/P76175 PubMed 12384697 http://www.ncbi.nlm.nih.gov/pubmed/12384697 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416109 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416109 RefSeq WP_001350514 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001350514 STRING 511145.b1592 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1592&targetmode=cogs STRING COG0038 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0038&targetmode=cogs SUPFAM SSF81340 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81340 UniProtKB CLCB_ECOLI http://www.uniprot.org/uniprot/CLCB_ECOLI UniProtKB-AC P76175 http://www.uniprot.org/uniprot/P76175 charge swissprot:CLCB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CLCB_ECOLI eggNOG COG0038 http://eggnogapi.embl.de/nog_data/html/tree/COG0038 eggNOG ENOG4105CMQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CMQ epestfind swissprot:CLCB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CLCB_ECOLI garnier swissprot:CLCB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CLCB_ECOLI helixturnhelix swissprot:CLCB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CLCB_ECOLI hmoment swissprot:CLCB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CLCB_ECOLI iep swissprot:CLCB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CLCB_ECOLI inforesidue swissprot:CLCB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CLCB_ECOLI octanol swissprot:CLCB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CLCB_ECOLI pepcoil swissprot:CLCB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CLCB_ECOLI pepdigest swissprot:CLCB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CLCB_ECOLI pepinfo swissprot:CLCB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CLCB_ECOLI pepnet swissprot:CLCB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CLCB_ECOLI pepstats swissprot:CLCB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CLCB_ECOLI pepwheel swissprot:CLCB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CLCB_ECOLI pepwindow swissprot:CLCB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CLCB_ECOLI sigcleave swissprot:CLCB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CLCB_ECOLI ## Database ID URL or Descriptions # BioGrid 4263191 5 # COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI 29105; Evidence={ECO:0000305}; # EcoGene EG13914 ycjQ # GO_function GO:0008270 zinc ion binding; IEA:InterPro. # GO_function GO:0016491 oxidoreductase activity; IEA:UniProtKB-KW. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.720 -; 1. # Gene3D 3.90.180.10 -; 2. # InterPro IPR002085 ADH_SF_Zn-type # InterPro IPR011032 GroES-like # InterPro IPR013149 ADH_C # InterPro IPR016040 NAD(P)-bd_dom # Organism YCJQ_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11695 PTHR11695; 2 # PATRIC 32117898 VBIEscCol129921_1369 # PIR D64880 D64880 # Pfam PF00107 ADH_zinc_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCJQ_ECOLI Uncharacterized zinc-type alcohol dehydrogenase-like protein YcjQ # RefSeq NP_415829 NC_000913.3 # RefSeq WP_000737347 NZ_LN832404.1 # SIMILARITY Belongs to the zinc-containing alcohol dehydrogenase family. {ECO 0000305}. # SUPFAM SSF50129 SSF50129 # SUPFAM SSF51735 SSF51735 # eggNOG COG1063 LUCA # eggNOG ENOG4107RRD Bacteria BLAST swissprot:YCJQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCJQ_ECOLI BioCyc ECOL316407:JW1306-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1306-MONOMER BioCyc EcoCyc:G6651-MONOMER http://biocyc.org/getid?id=EcoCyc:G6651-MONOMER DIP DIP-11608N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11608N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- EchoBASE EB3673 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3673 EcoGene EG13914 http://www.ecogene.org/geneInfo.php?eg_id=EG13914 EnsemblBacteria AAC74395 http://www.ensemblgenomes.org/id/AAC74395 EnsemblBacteria AAC74395 http://www.ensemblgenomes.org/id/AAC74395 EnsemblBacteria BAA14889 http://www.ensemblgenomes.org/id/BAA14889 EnsemblBacteria BAA14889 http://www.ensemblgenomes.org/id/BAA14889 EnsemblBacteria BAA14889 http://www.ensemblgenomes.org/id/BAA14889 EnsemblBacteria b1313 http://www.ensemblgenomes.org/id/b1313 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 Gene3D 3.90.180.10 http://www.cathdb.info/version/latest/superfamily/3.90.180.10 GeneID 945971 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945971 HOGENOM HOG000089521 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000089521&db=HOGENOM6 InParanoid P76043 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76043 IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR002085 http://www.ebi.ac.uk/interpro/entry/IPR002085 InterPro IPR011032 http://www.ebi.ac.uk/interpro/entry/IPR011032 InterPro IPR013149 http://www.ebi.ac.uk/interpro/entry/IPR013149 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 KEGG_Gene ecj:JW1306 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1306 KEGG_Gene eco:b1313 http://www.genome.jp/dbget-bin/www_bget?eco:b1313 OMA HRCEIAR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HRCEIAR PANTHER PTHR11695 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11695 PSORT swissprot:YCJQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCJQ_ECOLI PSORT-B swissprot:YCJQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCJQ_ECOLI PSORT2 swissprot:YCJQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCJQ_ECOLI Pfam PF00107 http://pfam.xfam.org/family/PF00107 Phobius swissprot:YCJQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCJQ_ECOLI PhylomeDB P76043 http://phylomedb.org/?seqid=P76043 ProteinModelPortal P76043 http://www.proteinmodelportal.org/query/uniprot/P76043 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415829 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415829 RefSeq WP_000737347 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000737347 SMR P76043 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76043 STRING 511145.b1313 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1313&targetmode=cogs SUPFAM SSF50129 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50129 SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB YCJQ_ECOLI http://www.uniprot.org/uniprot/YCJQ_ECOLI UniProtKB-AC P76043 http://www.uniprot.org/uniprot/P76043 charge swissprot:YCJQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCJQ_ECOLI eggNOG COG1063 http://eggnogapi.embl.de/nog_data/html/tree/COG1063 eggNOG ENOG4107RRD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107RRD epestfind swissprot:YCJQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCJQ_ECOLI garnier swissprot:YCJQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCJQ_ECOLI helixturnhelix swissprot:YCJQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCJQ_ECOLI hmoment swissprot:YCJQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCJQ_ECOLI iep swissprot:YCJQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCJQ_ECOLI inforesidue swissprot:YCJQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCJQ_ECOLI octanol swissprot:YCJQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCJQ_ECOLI pepcoil swissprot:YCJQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCJQ_ECOLI pepdigest swissprot:YCJQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCJQ_ECOLI pepinfo swissprot:YCJQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCJQ_ECOLI pepnet swissprot:YCJQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCJQ_ECOLI pepstats swissprot:YCJQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCJQ_ECOLI pepwheel swissprot:YCJQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCJQ_ECOLI pepwindow swissprot:YCJQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCJQ_ECOLI sigcleave swissprot:YCJQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCJQ_ECOLI ## Database ID URL or Descriptions # AltName RMLC_ECOLI Thymidine diphospho-4-keto-rhamnose 3,5-epimerase # AltName RMLC_ECOLI dTDP-4-keto-6-deoxyglucose 3,5-epimerase # AltName RMLC_ECOLI dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase # AltName RMLC_ECOLI dTDP-L-rhamnose synthase # BioGrid 4261258 213 # CATALYTIC ACTIVITY RMLC_ECOLI dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP- 4-dehydro-beta-L-rhamnose. # EcoGene EG11979 rfbC # FUNCTION RMLC_ECOLI Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose. {ECO 0000250}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008830 dTDP-4-dehydrorhamnose 3,5-epimerase activity; ISS:UniProtKB. # GO_process GO:0006974 cellular response to DNA damage stimulus; IMP:EcoCyc. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; ISS:UniProtKB. # GO_process GO:0009243 O antigen biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0019305 dTDP-rhamnose biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0045226 extracellular polysaccharide biosynthetic process; ISS:UniProtKB. # GO_process GO:0046677 response to antibiotic; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 2.60.120.10 -; 1. # INTERACTION RMLC_ECOLI P0A6F5 groL; NbExp=2; IntAct=EBI-557071, EBI-543750; # IntAct P37745 3 # InterPro IPR000888 dTDP_sugar_isom # InterPro IPR011051 RmlC_Cupin # InterPro IPR014710 RmlC-like_jellyroll # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00521 Streptomycin biosynthesis # KEGG_Pathway ko00523 Polyketide sugar unit biosynthesis # Organism RMLC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21047 PTHR21047 # PATHWAY RMLC_ECOLI Bacterial outer membrane biogenesis; LPS O-antigen biosynthesis. # PATHWAY RMLC_ECOLI Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis. # PATRIC 32119409 VBIEscCol129921_2114 # PIR I69651 I69651 # Pfam PF00908 dTDP_sugar_isom # ProDom PD001462 dTDP_sugar_isom # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RMLC_ECOLI dTDP-4-dehydrorhamnose 3,5-epimerase # RefSeq NP_416542 NC_000913.3 # RefSeq WP_001100981 NZ_LN832404.1 # SIMILARITY Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. {ECO 0000305}. # SUBUNIT Homodimer. {ECO 0000250}. # SUPFAM SSF51182 SSF51182 # TIGRFAMs TIGR01221 rmlC # eggNOG COG1898 LUCA # eggNOG ENOG4108URP Bacteria BLAST swissprot:RMLC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RMLC_ECOLI BioCyc ECOL316407:JW2023-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2023-MONOMER BioCyc EcoCyc:DTDPDEHYDRHAMEPIM-MONOMER http://biocyc.org/getid?id=EcoCyc:DTDPDEHYDRHAMEPIM-MONOMER BioCyc MetaCyc:DTDPDEHYDRHAMEPIM-MONOMER http://biocyc.org/getid?id=MetaCyc:DTDPDEHYDRHAMEPIM-MONOMER COG COG1898 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1898 DIP DIP-10681N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10681N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.1.3.13 http://www.genome.jp/dbget-bin/www_bget?EC:5.1.3.13 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U03041 http://www.ebi.ac.uk/ena/data/view/U03041 EMBL U09876 http://www.ebi.ac.uk/ena/data/view/U09876 ENZYME 5.1.3.13 http://enzyme.expasy.org/EC/5.1.3.13 EchoBASE EB1922 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1922 EcoGene EG11979 http://www.ecogene.org/geneInfo.php?eg_id=EG11979 EnsemblBacteria AAC75099 http://www.ensemblgenomes.org/id/AAC75099 EnsemblBacteria AAC75099 http://www.ensemblgenomes.org/id/AAC75099 EnsemblBacteria BAA15880 http://www.ensemblgenomes.org/id/BAA15880 EnsemblBacteria BAA15880 http://www.ensemblgenomes.org/id/BAA15880 EnsemblBacteria BAA15880 http://www.ensemblgenomes.org/id/BAA15880 EnsemblBacteria b2038 http://www.ensemblgenomes.org/id/b2038 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008830 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008830 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GO_process GO:0009243 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009243 GO_process GO:0019305 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019305 GO_process GO:0045226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045226 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 2.60.120.10 http://www.cathdb.info/version/latest/superfamily/2.60.120.10 GeneID 947482 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947482 HOGENOM HOG000227724 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000227724&db=HOGENOM6 InParanoid P37745 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37745 IntAct P37745 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37745* IntEnz 5.1.3.13 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.1.3.13 InterPro IPR000888 http://www.ebi.ac.uk/interpro/entry/IPR000888 InterPro IPR011051 http://www.ebi.ac.uk/interpro/entry/IPR011051 InterPro IPR014710 http://www.ebi.ac.uk/interpro/entry/IPR014710 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2023 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2023 KEGG_Gene eco:b2038 http://www.genome.jp/dbget-bin/www_bget?eco:b2038 KEGG_Orthology KO:K01790 http://www.genome.jp/dbget-bin/www_bget?KO:K01790 KEGG_Pathway ko00521 http://www.genome.jp/kegg-bin/show_pathway?ko00521 KEGG_Pathway ko00523 http://www.genome.jp/kegg-bin/show_pathway?ko00523 KEGG_Reaction rn:R06514 http://www.genome.jp/dbget-bin/www_bget?rn:R06514 MINT MINT-1257696 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1257696 OMA PMEQGKL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PMEQGKL PANTHER PTHR21047 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21047 PSORT swissprot:RMLC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RMLC_ECOLI PSORT-B swissprot:RMLC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RMLC_ECOLI PSORT2 swissprot:RMLC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RMLC_ECOLI Pfam PF00908 http://pfam.xfam.org/family/PF00908 Phobius swissprot:RMLC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RMLC_ECOLI PhylomeDB P37745 http://phylomedb.org/?seqid=P37745 ProteinModelPortal P37745 http://www.proteinmodelportal.org/query/uniprot/P37745 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7517390 http://www.ncbi.nlm.nih.gov/pubmed/7517390 PubMed 7517391 http://www.ncbi.nlm.nih.gov/pubmed/7517391 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416542 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416542 RefSeq WP_001100981 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001100981 SMR P37745 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37745 STRING 511145.b2038 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2038&targetmode=cogs STRING COG1898 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1898&targetmode=cogs SUPFAM SSF51182 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51182 TIGRFAMs TIGR01221 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01221 UniProtKB RMLC_ECOLI http://www.uniprot.org/uniprot/RMLC_ECOLI UniProtKB-AC P37745 http://www.uniprot.org/uniprot/P37745 charge swissprot:RMLC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RMLC_ECOLI eggNOG COG1898 http://eggnogapi.embl.de/nog_data/html/tree/COG1898 eggNOG ENOG4108URP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108URP epestfind swissprot:RMLC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RMLC_ECOLI garnier swissprot:RMLC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RMLC_ECOLI helixturnhelix swissprot:RMLC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RMLC_ECOLI hmoment swissprot:RMLC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RMLC_ECOLI iep swissprot:RMLC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RMLC_ECOLI inforesidue swissprot:RMLC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RMLC_ECOLI octanol swissprot:RMLC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RMLC_ECOLI pepcoil swissprot:RMLC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RMLC_ECOLI pepdigest swissprot:RMLC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RMLC_ECOLI pepinfo swissprot:RMLC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RMLC_ECOLI pepnet swissprot:RMLC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RMLC_ECOLI pepstats swissprot:RMLC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RMLC_ECOLI pepwheel swissprot:RMLC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RMLC_ECOLI pepwindow swissprot:RMLC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RMLC_ECOLI sigcleave swissprot:RMLC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RMLC_ECOLI ## Database ID URL or Descriptions # EcoGene EG40004 insD6 # FUNCTION INSD6_ECOLI Involved in the transposition of the insertion sequence IS2. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006310 DNA recombination; IEA:UniProtKB-KW. # GO_process GO:0015074 DNA integration; IEA:InterPro. # GO_process GO:0032196 transposition; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 3.30.420.10 -; 1. # InterPro IPR001584 Integrase_cat-core # InterPro IPR012337 RNaseH-like_dom # InterPro IPR025948 HTH-like_dom # Organism INSD6_ECOLI Escherichia coli (strain K12) # PIR A64764 C65092 # PROSITE PS50994 INTEGRASE # Pfam PF00665 rve # Pfam PF13276 HTH_21 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSD6_ECOLI Transposase InsD for insertion element IS2K # RefSeq NP_061399 NC_002483.1 # RefSeq NP_414895 NC_000913.3 # RefSeq NP_415920 NC_000913.3 # RefSeq NP_416500 NC_000913.3 # RefSeq NP_417337 NC_000913.3 # RefSeq NP_417517 NC_000913.3 # RefSeq NP_418693 NC_000913.3 # RefSeq WP_000376502 NZ_LN832404.1 # RefSeq YP_424823 NC_007635.1 # SIMILARITY Contains 1 integrase catalytic domain. {ECO:0000255|PROSITE-ProRule PRU00457}. # SUPFAM SSF53098 SSF53098 # eggNOG ENOG4108MVM Bacteria # eggNOG ENOG410Z4Y8 LUCA BLAST swissprot:INSD6_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSD6_ECOLI DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB4712 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4712 EcoGene EG40004 http://www.ecogene.org/geneInfo.php?eg_id=EG40004 EnsemblBacteria AAC77229 http://www.ensemblgenomes.org/id/AAC77229 EnsemblBacteria AAC77229 http://www.ensemblgenomes.org/id/AAC77229 EnsemblBacteria BAE78269 http://www.ensemblgenomes.org/id/BAE78269 EnsemblBacteria BAE78269 http://www.ensemblgenomes.org/id/BAE78269 EnsemblBacteria BAE78269 http://www.ensemblgenomes.org/id/BAE78269 EnsemblBacteria b4273 http://www.ensemblgenomes.org/id/b4273 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0015074 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015074 GO_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 3.30.420.10 http://www.cathdb.info/version/latest/superfamily/3.30.420.10 GeneID 1263540 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263540 GeneID 3829341 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3829341 GeneID 945203 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945203 GeneID 945952 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945952 GeneID 946403 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946403 GeneID 947346 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947346 GeneID 947517 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947517 GeneID 948779 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948779 InParanoid P0CF58 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CF58 InterPro IPR001584 http://www.ebi.ac.uk/interpro/entry/IPR001584 InterPro IPR012337 http://www.ebi.ac.uk/interpro/entry/IPR012337 InterPro IPR025948 http://www.ebi.ac.uk/interpro/entry/IPR025948 KEGG_Gene ecj:JW4230 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4230 KEGG_Gene eco:b0361 http://www.genome.jp/dbget-bin/www_bget?eco:b0361 KEGG_Gene eco:b1402 http://www.genome.jp/dbget-bin/www_bget?eco:b1402 KEGG_Gene eco:b1996 http://www.genome.jp/dbget-bin/www_bget?eco:b1996 KEGG_Gene eco:b2860 http://www.genome.jp/dbget-bin/www_bget?eco:b2860 KEGG_Gene eco:b3045 http://www.genome.jp/dbget-bin/www_bget?eco:b3045 KEGG_Gene eco:b4273 http://www.genome.jp/dbget-bin/www_bget?eco:b4273 PROSITE PS50994 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50994 PSORT swissprot:INSD6_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSD6_ECOLI PSORT-B swissprot:INSD6_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSD6_ECOLI PSORT2 swissprot:INSD6_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSD6_ECOLI Pfam PF00665 http://pfam.xfam.org/family/PF00665 Pfam PF13276 http://pfam.xfam.org/family/PF13276 Phobius swissprot:INSD6_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSD6_ECOLI PhylomeDB P0CF58 http://phylomedb.org/?seqid=P0CF58 ProteinModelPortal P0CF58 http://www.proteinmodelportal.org/query/uniprot/P0CF58 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_061399 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061399 RefSeq NP_414895 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414895 RefSeq NP_415920 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415920 RefSeq NP_416500 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416500 RefSeq NP_417337 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417337 RefSeq NP_417517 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417517 RefSeq NP_418693 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418693 RefSeq WP_000376502 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000376502 RefSeq YP_424823 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_424823 SMR P0CF58 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0CF58 STRING 511145.b4273 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4273&targetmode=cogs SUPFAM SSF53098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098 UniProtKB INSD6_ECOLI http://www.uniprot.org/uniprot/INSD6_ECOLI UniProtKB-AC P0CF58 http://www.uniprot.org/uniprot/P0CF58 charge swissprot:INSD6_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSD6_ECOLI eggNOG ENOG4108MVM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MVM eggNOG ENOG410Z4Y8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Z4Y8 epestfind swissprot:INSD6_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSD6_ECOLI garnier swissprot:INSD6_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSD6_ECOLI helixturnhelix swissprot:INSD6_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSD6_ECOLI hmoment swissprot:INSD6_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSD6_ECOLI iep swissprot:INSD6_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSD6_ECOLI inforesidue swissprot:INSD6_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSD6_ECOLI octanol swissprot:INSD6_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSD6_ECOLI pepcoil swissprot:INSD6_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSD6_ECOLI pepdigest swissprot:INSD6_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSD6_ECOLI pepinfo swissprot:INSD6_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSD6_ECOLI pepnet swissprot:INSD6_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSD6_ECOLI pepstats swissprot:INSD6_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSD6_ECOLI pepwheel swissprot:INSD6_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSD6_ECOLI pepwindow swissprot:INSD6_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSD6_ECOLI sigcleave swissprot:INSD6_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSD6_ECOLI ## Database ID URL or Descriptions # BioGrid 4263477 7 # EcoGene EG12838 yrdA # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0043167 ion binding # InterPro IPR001451 Hexapep # InterPro IPR011004 Trimer_LpxA-like # Organism YRDA_ECOLI Escherichia coli (strain K12) # PATRIC 32121992 VBIEscCol129921_3373 # PDB 3TIO X-ray; 1.41 A; A/B/C/D/E/F=2-184 # PDB 3TIS X-ray; 2.30 A; A/B/C=2-184 # PIR B65120 B65120 # Pfam PF00132 Hexapep; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YRDA_ECOLI Protein YrdA # RefSeq NP_417738 NC_000913.3 # RefSeq WP_001286216 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA58076.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the gamma-class carbonic anhydrase family. {ECO 0000305}. # SUPFAM SSF51161 SSF51161 # eggNOG COG0663 LUCA # eggNOG ENOG4108Z0R Bacteria BLAST swissprot:YRDA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YRDA_ECOLI BioCyc ECOL316407:JW5710-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5710-MONOMER BioCyc EcoCyc:G7696-MONOMER http://biocyc.org/getid?id=EcoCyc:G7696-MONOMER DIP DIP-48232N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48232N DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2687 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2687 EcoGene EG12838 http://www.ecogene.org/geneInfo.php?eg_id=EG12838 EnsemblBacteria AAC76304 http://www.ensemblgenomes.org/id/AAC76304 EnsemblBacteria AAC76304 http://www.ensemblgenomes.org/id/AAC76304 EnsemblBacteria BAE78012 http://www.ensemblgenomes.org/id/BAE78012 EnsemblBacteria BAE78012 http://www.ensemblgenomes.org/id/BAE78012 EnsemblBacteria BAE78012 http://www.ensemblgenomes.org/id/BAE78012 EnsemblBacteria b3279 http://www.ensemblgenomes.org/id/b3279 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GeneID 947775 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947775 HOGENOM HOG000049430 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000049430&db=HOGENOM6 InParanoid P0A9W9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9W9 InterPro IPR001451 http://www.ebi.ac.uk/interpro/entry/IPR001451 InterPro IPR011004 http://www.ebi.ac.uk/interpro/entry/IPR011004 KEGG_Gene ecj:JW5710 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5710 KEGG_Gene eco:b3279 http://www.genome.jp/dbget-bin/www_bget?eco:b3279 OMA KYSANNY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KYSANNY PDB 3TIO http://www.ebi.ac.uk/pdbe-srv/view/entry/3TIO PDB 3TIS http://www.ebi.ac.uk/pdbe-srv/view/entry/3TIS PDBsum 3TIO http://www.ebi.ac.uk/pdbsum/3TIO PDBsum 3TIS http://www.ebi.ac.uk/pdbsum/3TIS PSORT swissprot:YRDA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YRDA_ECOLI PSORT-B swissprot:YRDA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YRDA_ECOLI PSORT2 swissprot:YRDA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YRDA_ECOLI Pfam PF00132 http://pfam.xfam.org/family/PF00132 Phobius swissprot:YRDA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YRDA_ECOLI PhylomeDB P0A9W9 http://phylomedb.org/?seqid=P0A9W9 ProteinModelPortal P0A9W9 http://www.proteinmodelportal.org/query/uniprot/P0A9W9 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417738 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417738 RefSeq WP_001286216 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001286216 SMR P0A9W9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9W9 STRING 511145.b3279 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3279&targetmode=cogs SUPFAM SSF51161 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51161 UniProtKB YRDA_ECOLI http://www.uniprot.org/uniprot/YRDA_ECOLI UniProtKB-AC P0A9W9 http://www.uniprot.org/uniprot/P0A9W9 charge swissprot:YRDA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YRDA_ECOLI eggNOG COG0663 http://eggnogapi.embl.de/nog_data/html/tree/COG0663 eggNOG ENOG4108Z0R http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Z0R epestfind swissprot:YRDA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YRDA_ECOLI garnier swissprot:YRDA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YRDA_ECOLI helixturnhelix swissprot:YRDA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YRDA_ECOLI hmoment swissprot:YRDA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YRDA_ECOLI iep swissprot:YRDA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YRDA_ECOLI inforesidue swissprot:YRDA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YRDA_ECOLI octanol swissprot:YRDA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YRDA_ECOLI pepcoil swissprot:YRDA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YRDA_ECOLI pepdigest swissprot:YRDA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YRDA_ECOLI pepinfo swissprot:YRDA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YRDA_ECOLI pepnet swissprot:YRDA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YRDA_ECOLI pepstats swissprot:YRDA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YRDA_ECOLI pepwheel swissprot:YRDA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YRDA_ECOLI pepwindow swissprot:YRDA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YRDA_ECOLI sigcleave swissprot:YRDA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YRDA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262484 6 # DISRUPTION PHENOTYPE Mutants are unable to use DNA as a sole carbon and energy source and show decreased competitive fitness when cocultured with wild-type cells. {ECO:0000269|PubMed 16707682}. # EcoGene EG12923 hofO # FUNCTION HOFO_ECOLI Required for the use of extracellular DNA as a nutrient. {ECO 0000269|PubMed 16707682}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0015976 carbon utilization; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0008150 biological_process # IntAct P45751 4 # KEGG_Brite ko02044 Secretion system # Organism HOFO_ECOLI Escherichia coli (strain K12) # PATRIC 32122218 VBIEscCol129921_3486 # PIR D65134 D65134 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HOFO_ECOLI Putative DNA utilization protein HofO # RefSeq NP_417852 NC_000913.3 # RefSeq WP_001055759 NZ_LN832404.1 # SUBCELLULAR LOCATION HOFO_ECOLI Cell membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. # eggNOG ENOG4105XPX Bacteria # eggNOG ENOG411265W LUCA BLAST swissprot:HOFO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HOFO_ECOLI BioCyc ECOL316407:JW3356-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3356-MONOMER BioCyc EcoCyc:G7737-MONOMER http://biocyc.org/getid?id=EcoCyc:G7737-MONOMER DIP DIP-12919N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12919N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01974-05 http://dx.doi.org/10.1128/JB.01974-05 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2759 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2759 EcoGene EG12923 http://www.ecogene.org/geneInfo.php?eg_id=EG12923 EnsemblBacteria AAC76418 http://www.ensemblgenomes.org/id/AAC76418 EnsemblBacteria AAC76418 http://www.ensemblgenomes.org/id/AAC76418 EnsemblBacteria BAE77898 http://www.ensemblgenomes.org/id/BAE77898 EnsemblBacteria BAE77898 http://www.ensemblgenomes.org/id/BAE77898 EnsemblBacteria BAE77898 http://www.ensemblgenomes.org/id/BAE77898 EnsemblBacteria b3393 http://www.ensemblgenomes.org/id/b3393 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0015976 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015976 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 947899 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947899 HOGENOM HOG000125521 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125521&db=HOGENOM6 IntAct P45751 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45751* KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW3356 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3356 KEGG_Gene eco:b3393 http://www.genome.jp/dbget-bin/www_bget?eco:b3393 KEGG_Orthology KO:K12290 http://www.genome.jp/dbget-bin/www_bget?KO:K12290 MINT MINT-1287965 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1287965 OMA DMLFDWW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DMLFDWW PSORT swissprot:HOFO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HOFO_ECOLI PSORT-B swissprot:HOFO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HOFO_ECOLI PSORT2 swissprot:HOFO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HOFO_ECOLI Phobius swissprot:HOFO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HOFO_ECOLI ProteinModelPortal P45751 http://www.proteinmodelportal.org/query/uniprot/P45751 PubMed 16707682 http://www.ncbi.nlm.nih.gov/pubmed/16707682 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417852 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417852 RefSeq WP_001055759 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001055759 STRING 511145.b3393 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3393&targetmode=cogs UniProtKB HOFO_ECOLI http://www.uniprot.org/uniprot/HOFO_ECOLI UniProtKB-AC P45751 http://www.uniprot.org/uniprot/P45751 charge swissprot:HOFO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HOFO_ECOLI eggNOG ENOG4105XPX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105XPX eggNOG ENOG411265W http://eggnogapi.embl.de/nog_data/html/tree/ENOG411265W epestfind swissprot:HOFO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HOFO_ECOLI garnier swissprot:HOFO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HOFO_ECOLI helixturnhelix swissprot:HOFO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HOFO_ECOLI hmoment swissprot:HOFO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HOFO_ECOLI iep swissprot:HOFO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HOFO_ECOLI inforesidue swissprot:HOFO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HOFO_ECOLI octanol swissprot:HOFO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HOFO_ECOLI pepcoil swissprot:HOFO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HOFO_ECOLI pepdigest swissprot:HOFO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HOFO_ECOLI pepinfo swissprot:HOFO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HOFO_ECOLI pepnet swissprot:HOFO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HOFO_ECOLI pepstats swissprot:HOFO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HOFO_ECOLI pepwheel swissprot:HOFO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HOFO_ECOLI pepwindow swissprot:HOFO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HOFO_ECOLI sigcleave swissprot:HOFO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HOFO_ECOLI ## Database ID URL or Descriptions # BioGrid 4262467 8 # COFACTOR Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI 49601; Note=Binds 1 [2Fe-2S] cluster.; # EcoGene EG11181 bfd # FUNCTION BFD_ECOLI Seems to associate with BFR; could be a general redox and/or regulatory component participating in the iron storage mobilization functions of BFR. Could participate in the release or the delivery of iron from/to bacterioferritin (or other iron complexes). # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051537 2 iron, 2 sulfur cluster binding; IDA:EcoCyc. # GO_process GO:0055114 oxidation-reduction process; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # InterPro IPR007419 BFD-like_2Fe2S-bd_dom # Organism BFD_ECOLI Escherichia coli (strain K12) # PATRIC 32122106 VBIEscCol129921_3430 # PIR JV0033 QQECB7 # Pfam PF04324 Fer2_BFD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BFD_ECOLI Bacterioferritin-associated ferredoxin # RefSeq NP_417796 NC_000913.3 # RefSeq WP_000289085 NZ_LN832404.1 # SUBUNIT BFD_ECOLI Monomer. # eggNOG COG2906 LUCA # eggNOG ENOG4105W53 Bacteria BLAST swissprot:BFD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BFD_ECOLI BioCyc ECOL316407:JW3299-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3299-MONOMER BioCyc EcoCyc:EG11181-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11181-MONOMER COG COG2906 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2906 DOI 10.1006/bbrc.1996.1856 http://dx.doi.org/10.1006/bbrc.1996.1856 DOI 10.1021/bi9600862 http://dx.doi.org/10.1021/bi9600862 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AF058450 http://www.ebi.ac.uk/ena/data/view/AF058450 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M27176 http://www.ebi.ac.uk/ena/data/view/M27176 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB1168 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1168 EcoGene EG11181 http://www.ecogene.org/geneInfo.php?eg_id=EG11181 EnsemblBacteria AAC76362 http://www.ensemblgenomes.org/id/AAC76362 EnsemblBacteria AAC76362 http://www.ensemblgenomes.org/id/AAC76362 EnsemblBacteria BAE77954 http://www.ensemblgenomes.org/id/BAE77954 EnsemblBacteria BAE77954 http://www.ensemblgenomes.org/id/BAE77954 EnsemblBacteria BAE77954 http://www.ensemblgenomes.org/id/BAE77954 EnsemblBacteria b3337 http://www.ensemblgenomes.org/id/b3337 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051537 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051537 GO_process GO:0055114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 947836 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947836 HOGENOM HOG000262408 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000262408&db=HOGENOM6 InParanoid P0AE56 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AE56 IntAct P0AE56 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AE56* InterPro IPR007419 http://www.ebi.ac.uk/interpro/entry/IPR007419 KEGG_Gene ecj:JW3299 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3299 KEGG_Gene eco:b3337 http://www.genome.jp/dbget-bin/www_bget?eco:b3337 KEGG_Orthology KO:K02192 http://www.genome.jp/dbget-bin/www_bget?KO:K02192 OMA REIMQDE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=REIMQDE PSORT swissprot:BFD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BFD_ECOLI PSORT-B swissprot:BFD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BFD_ECOLI PSORT2 swissprot:BFD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BFD_ECOLI Pfam PF04324 http://pfam.xfam.org/family/PF04324 Phobius swissprot:BFD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BFD_ECOLI PhylomeDB P0AE56 http://phylomedb.org/?seqid=P0AE56 ProteinModelPortal P0AE56 http://www.proteinmodelportal.org/query/uniprot/P0AE56 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2661540 http://www.ncbi.nlm.nih.gov/pubmed/2661540 PubMed 8639572 http://www.ncbi.nlm.nih.gov/pubmed/8639572 PubMed 8954950 http://www.ncbi.nlm.nih.gov/pubmed/8954950 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417796 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417796 RefSeq WP_000289085 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000289085 SMR P0AE56 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AE56 STRING 511145.b3337 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3337&targetmode=cogs STRING COG2906 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2906&targetmode=cogs UniProtKB BFD_ECOLI http://www.uniprot.org/uniprot/BFD_ECOLI UniProtKB-AC P0AE56 http://www.uniprot.org/uniprot/P0AE56 charge swissprot:BFD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BFD_ECOLI eggNOG COG2906 http://eggnogapi.embl.de/nog_data/html/tree/COG2906 eggNOG ENOG4105W53 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105W53 epestfind swissprot:BFD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BFD_ECOLI garnier swissprot:BFD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BFD_ECOLI helixturnhelix swissprot:BFD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BFD_ECOLI hmoment swissprot:BFD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BFD_ECOLI iep swissprot:BFD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BFD_ECOLI inforesidue swissprot:BFD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BFD_ECOLI octanol swissprot:BFD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BFD_ECOLI pepcoil swissprot:BFD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BFD_ECOLI pepdigest swissprot:BFD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BFD_ECOLI pepinfo swissprot:BFD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BFD_ECOLI pepnet swissprot:BFD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BFD_ECOLI pepstats swissprot:BFD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BFD_ECOLI pepwheel swissprot:BFD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BFD_ECOLI pepwindow swissprot:BFD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BFD_ECOLI sigcleave swissprot:BFD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BFD_ECOLI ## Database ID URL or Descriptions # AltName INTG_ECOLI Putative lambdoid prophage defective integrase # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG14259 intG # GO_process GO:0006310 DNA recombination; IEA:UniProtKB-KW. # GO_process GO:0015074 DNA integration; IEA:UniProtKB-KW. # GO_process GO:0046718 viral entry into host cell; IEA:UniProtKB-KW. # GO_process GO:0075713 establishment of integrated proviral latency; IEA:UniProtKB-KW. # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0044403 symbiosis, encompassing mutualism through parasitism # Organism INTG_ECOLI Escherichia coli (strain K12) # PIR E64957 E64957 # Proteomes UP000000625 Chromosome # RecName Putative protein IntG {ECO 0000305} # RefSeq WP_015675427 NZ_LN832404.1 # SIMILARITY Belongs to the 'phage' integrase family. {ECO 0000305}. BLAST swissprot:INTG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INTG_ECOLI BioCyc EcoCyc:G7044-MONOMER http://biocyc.org/getid?id=EcoCyc:G7044-MONOMER DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14259 http://www.ecogene.org/geneInfo.php?eg_id=EG14259 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0015074 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015074 GO_process GO:0046718 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046718 GO_process GO:0075713 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0075713 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0044403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403 OMA ITHLNPH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ITHLNPH PSORT swissprot:INTG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INTG_ECOLI PSORT-B swissprot:INTG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INTG_ECOLI PSORT2 swissprot:INTG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INTG_ECOLI Phobius swissprot:INTG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INTG_ECOLI ProteinModelPortal P76323 http://www.proteinmodelportal.org/query/uniprot/P76323 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_015675427 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_015675427 UniProtKB INTG_ECOLI http://www.uniprot.org/uniprot/INTG_ECOLI UniProtKB-AC P76323 http://www.uniprot.org/uniprot/P76323 charge swissprot:INTG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INTG_ECOLI epestfind swissprot:INTG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INTG_ECOLI garnier swissprot:INTG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INTG_ECOLI helixturnhelix swissprot:INTG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INTG_ECOLI hmoment swissprot:INTG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INTG_ECOLI iep swissprot:INTG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INTG_ECOLI inforesidue swissprot:INTG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INTG_ECOLI octanol swissprot:INTG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INTG_ECOLI pepcoil swissprot:INTG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INTG_ECOLI pepdigest swissprot:INTG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INTG_ECOLI pepinfo swissprot:INTG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INTG_ECOLI pepnet swissprot:INTG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INTG_ECOLI pepstats swissprot:INTG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INTG_ECOLI pepwheel swissprot:INTG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INTG_ECOLI pepwindow swissprot:INTG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INTG_ECOLI sigcleave swissprot:INTG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INTG_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES SUPH_ECOLI Kinetic parameters KM=0.12 mM for imido-di-phosphate (in the presence of magnesium ion as cofactor and at pH 9) {ECO 0000269|PubMed 15657928, ECO 0000269|PubMed 16990279}; KM=1.4 mM for fructose-1-phosphate (in the presence of magnesium ion as cofactor and at pH 9) {ECO 0000269|PubMed 15657928, ECO 0000269|PubMed 16990279}; KM=2.4 mM for ribose-5-phosphate (in the presence of magnesium ion as cofactor and at pH 9) {ECO 0000269|PubMed 15657928, ECO 0000269|PubMed 16990279}; KM=3.1 mM for glucose-6-phosphate (in the presence of magnesium ion as cofactor and at pH 9) {ECO 0000269|PubMed 15657928, ECO 0000269|PubMed 16990279}; KM=4.9 mM for acetyl-phosphate (in the presence of magnesium ion as cofactor and at pH 9) {ECO 0000269|PubMed 15657928, ECO 0000269|PubMed 16990279}; KM=6 mM for ribose-5-phosphate (at pH 5.4) {ECO 0000269|PubMed 15657928, ECO 0000269|PubMed 16990279}; KM=6 mM for glycerol-1-phosphate (at pH 5.4) {ECO 0000269|PubMed 15657928, ECO 0000269|PubMed 16990279}; KM=4.5 mM for glycerol-2-phosphate (at pH 5.4) {ECO 0000269|PubMed 15657928, ECO 0000269|PubMed 16990279}; Note=Glucose-6-phosphate is also a good substrate with a relative activity of 62.5% versus the activity with ribose-5- phosphate.; # BioGrid 4262995 213 # CATALYTIC ACTIVITY Sugar phosphate + H(2)O = sugar + phosphate. {ECO:0000269|PubMed 15657928}. # COFACTOR SUPH_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 16990279}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 16990279}; Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000269|PubMed 16990279}; Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 16990279}; Note=Magnesium. Can also use other divalent metal cations as manganese, cobalt or zinc. {ECO 0000269|PubMed 16990279}; # EcoGene EG13327 supH # FUNCTION SUPH_ECOLI Catalyzes the hydrolysis of sugar phosphate to sugar and inorganic phosphate. Has a wide substrate specificity catalyzing the hydrolysis of ribose-5-phosphate, glucose-6-phosphate, fructose-1-phosphate, acetyl-phosphate, glycerol-1-phosphate, glycerol-2-phosphate, 2-deoxy-glucose-6-phosphate, mannose-6- phosphate and fructose-6-phosphate. Appears to have a low level of phosphotransferase activity using monophosphates as the phosphate donor. {ECO 0000269|PubMed 15657928, ECO 0000269|PubMed 15808744, ECO 0000269|PubMed 16990279}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0000287 magnesium ion binding; IDA:UniProtKB. # GO_function GO:0050308 sugar-phosphatase activity; IDA:EcoCyc. # GO_process GO:0044283 small molecule biosynthetic process; IBA:GO_Central. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.1000 -; 2. # INDUCTION Regulated by the cAMP receptor protein crp. {ECO 0000305}. # IntAct P75792 10 # InterPro IPR000150 Hypothet_cof # InterPro IPR006379 HAD-SF_hydro_IIB # InterPro IPR023214 HAD-like_dom # KEGG_Brite ko01000 Enzymes # Organism SUPH_ECOLI Escherichia coli (strain K12) # PATRIC 32116847 VBIEscCol129921_0849 # PDB 1RLM X-ray; 1.90 A; A/B/C/D=1-271 # PDB 1RLO X-ray; 2.00 A; A/B/C/D=1-271 # PDB 1RLT X-ray; 2.20 A; A/B/C/D=1-271 # PDB 2HF2 X-ray; 1.90 A; A/B=1-271 # PIR F64819 F64819 # PROSITE PS01229 COF_2 # Pfam PF08282 Hydrolase_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SUPH_ECOLI Sugar phosphatase YbiV # RefSeq NP_415343 NC_000913.3 # RefSeq WP_000114272 NZ_LN832404.1 # SIMILARITY Belongs to the HAD-like hydrolase superfamily. Cof family. SupH subfamily. {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 15657928, ECO:0000269|Ref.7}. # SUPFAM SSF56784 SSF56784 # TIGRFAMs TIGR00099 Cof-subfamily # TIGRFAMs TIGR01484 HAD-SF-IIB # eggNOG COG0561 LUCA # eggNOG ENOG4108HCJ Bacteria BLAST swissprot:SUPH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SUPH_ECOLI BioCyc ECOL316407:JW0806-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0806-MONOMER BioCyc EcoCyc:G6425-MONOMER http://biocyc.org/getid?id=EcoCyc:G6425-MONOMER BioCyc MetaCyc:G6425-MONOMER http://biocyc.org/getid?id=MetaCyc:G6425-MONOMER COG COG0561 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0561 DOI 10.1002/prot.20267 http://dx.doi.org/10.1002/prot.20267 DOI 10.1016/j.fmrre.2004.12.006 http://dx.doi.org/10.1016/j.fmrre.2004.12.006 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M605449200 http://dx.doi.org/10.1074/jbc.M605449200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.3.23 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.23 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.3.23 http://enzyme.expasy.org/EC/3.1.3.23 EchoBASE EB3111 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3111 EcoGene EG13327 http://www.ecogene.org/geneInfo.php?eg_id=EG13327 EnsemblBacteria AAC73909 http://www.ensemblgenomes.org/id/AAC73909 EnsemblBacteria AAC73909 http://www.ensemblgenomes.org/id/AAC73909 EnsemblBacteria BAA35503 http://www.ensemblgenomes.org/id/BAA35503 EnsemblBacteria BAA35503 http://www.ensemblgenomes.org/id/BAA35503 EnsemblBacteria BAA35503 http://www.ensemblgenomes.org/id/BAA35503 EnsemblBacteria b0822 http://www.ensemblgenomes.org/id/b0822 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0050308 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050308 GO_process GO:0044283 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044283 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.1000 http://www.cathdb.info/version/latest/superfamily/3.40.50.1000 GeneID 945432 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945432 HOGENOM HOG000184782 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000184782&db=HOGENOM6 InParanoid P75792 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75792 IntAct P75792 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75792* IntEnz 3.1.3.23 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.23 InterPro IPR000150 http://www.ebi.ac.uk/interpro/entry/IPR000150 InterPro IPR006379 http://www.ebi.ac.uk/interpro/entry/IPR006379 InterPro IPR023214 http://www.ebi.ac.uk/interpro/entry/IPR023214 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0806 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0806 KEGG_Gene eco:b0822 http://www.genome.jp/dbget-bin/www_bget?eco:b0822 KEGG_Orthology KO:K07757 http://www.genome.jp/dbget-bin/www_bget?KO:K07757 KEGG_Reaction rn:R00804 http://www.genome.jp/dbget-bin/www_bget?rn:R00804 OMA QRVSDYH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QRVSDYH PDB 1RLM http://www.ebi.ac.uk/pdbe-srv/view/entry/1RLM PDB 1RLO http://www.ebi.ac.uk/pdbe-srv/view/entry/1RLO PDB 1RLT http://www.ebi.ac.uk/pdbe-srv/view/entry/1RLT PDB 2HF2 http://www.ebi.ac.uk/pdbe-srv/view/entry/2HF2 PDBsum 1RLM http://www.ebi.ac.uk/pdbsum/1RLM PDBsum 1RLO http://www.ebi.ac.uk/pdbsum/1RLO PDBsum 1RLT http://www.ebi.ac.uk/pdbsum/1RLT PDBsum 2HF2 http://www.ebi.ac.uk/pdbsum/2HF2 PROSITE PS01229 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01229 PSORT swissprot:SUPH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SUPH_ECOLI PSORT-B swissprot:SUPH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SUPH_ECOLI PSORT2 swissprot:SUPH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SUPH_ECOLI Pfam PF08282 http://pfam.xfam.org/family/PF08282 Phobius swissprot:SUPH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SUPH_ECOLI PhylomeDB P75792 http://phylomedb.org/?seqid=P75792 ProteinModelPortal P75792 http://www.proteinmodelportal.org/query/uniprot/P75792 PubMed 15657928 http://www.ncbi.nlm.nih.gov/pubmed/15657928 PubMed 15808744 http://www.ncbi.nlm.nih.gov/pubmed/15808744 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16990279 http://www.ncbi.nlm.nih.gov/pubmed/16990279 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415343 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415343 RefSeq WP_000114272 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000114272 SMR P75792 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75792 STRING 511145.b0822 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0822&targetmode=cogs STRING COG0561 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0561&targetmode=cogs SUPFAM SSF56784 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784 TIGRFAMs TIGR00099 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00099 TIGRFAMs TIGR01484 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01484 UniProtKB SUPH_ECOLI http://www.uniprot.org/uniprot/SUPH_ECOLI UniProtKB-AC P75792 http://www.uniprot.org/uniprot/P75792 charge swissprot:SUPH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SUPH_ECOLI eggNOG COG0561 http://eggnogapi.embl.de/nog_data/html/tree/COG0561 eggNOG ENOG4108HCJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108HCJ epestfind swissprot:SUPH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SUPH_ECOLI garnier swissprot:SUPH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SUPH_ECOLI helixturnhelix swissprot:SUPH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SUPH_ECOLI hmoment swissprot:SUPH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SUPH_ECOLI iep swissprot:SUPH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SUPH_ECOLI inforesidue swissprot:SUPH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SUPH_ECOLI octanol swissprot:SUPH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SUPH_ECOLI pepcoil swissprot:SUPH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SUPH_ECOLI pepdigest swissprot:SUPH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SUPH_ECOLI pepinfo swissprot:SUPH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SUPH_ECOLI pepnet swissprot:SUPH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SUPH_ECOLI pepstats swissprot:SUPH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SUPH_ECOLI pepwheel swissprot:SUPH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SUPH_ECOLI pepwindow swissprot:SUPH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SUPH_ECOLI sigcleave swissprot:SUPH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SUPH_ECOLI ## Database ID URL or Descriptions # BioGrid 4259934 15 # EcoGene EG13311 ybgO # FUNCTION YBGO_ECOLI May be involved in a fimbrial system chaperoned by YbgP and exported by YbgQ. # GO_component GO:0009289 pilus; IEA:InterPro. # GO_process GO:0007155 cell adhesion; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0007155 cell adhesion # Gene3D 2.60.40.1090 -; 1. # InterPro IPR000259 Adhesion_dom_fimbrial # InterPro IPR008966 Adhesion_dom # Organism YBGO_ECOLI Escherichia coli (strain K12) # PATRIC 32116627 VBIEscCol129921_0746 # PIR C64807 C64807 # Pfam PF00419 Fimbrial # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBGO_ECOLI Uncharacterized protein YbgO # RefSeq NP_415244 NC_000913.3 # RefSeq WP_001272410 NZ_LN832404.1 # SIMILARITY To E.coli YqiI. {ECO 0000305}. # SUPFAM SSF49401 SSF49401 # eggNOG ENOG4108MY7 Bacteria # eggNOG ENOG4110VJC LUCA BLAST swissprot:YBGO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBGO_ECOLI BioCyc ECOL316407:JW5098-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5098-MONOMER BioCyc EcoCyc:G6385-MONOMER http://biocyc.org/getid?id=EcoCyc:G6385-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3095 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3095 EcoGene EG13311 http://www.ecogene.org/geneInfo.php?eg_id=EG13311 EnsemblBacteria AAC73810 http://www.ensemblgenomes.org/id/AAC73810 EnsemblBacteria AAC73810 http://www.ensemblgenomes.org/id/AAC73810 EnsemblBacteria BAA35380 http://www.ensemblgenomes.org/id/BAA35380 EnsemblBacteria BAA35380 http://www.ensemblgenomes.org/id/BAA35380 EnsemblBacteria BAA35380 http://www.ensemblgenomes.org/id/BAA35380 EnsemblBacteria b0716 http://www.ensemblgenomes.org/id/b0716 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009289 GO_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 Gene3D 2.60.40.1090 http://www.cathdb.info/version/latest/superfamily/2.60.40.1090 GeneID 947550 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947550 HOGENOM HOG000125082 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125082&db=HOGENOM6 InParanoid P75748 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75748 InterPro IPR000259 http://www.ebi.ac.uk/interpro/entry/IPR000259 InterPro IPR008966 http://www.ebi.ac.uk/interpro/entry/IPR008966 KEGG_Gene ecj:JW5098 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5098 KEGG_Gene eco:b0716 http://www.genome.jp/dbget-bin/www_bget?eco:b0716 OMA SIYPENQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SIYPENQ PSORT swissprot:YBGO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBGO_ECOLI PSORT-B swissprot:YBGO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBGO_ECOLI PSORT2 swissprot:YBGO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBGO_ECOLI Pfam PF00419 http://pfam.xfam.org/family/PF00419 Phobius swissprot:YBGO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBGO_ECOLI ProteinModelPortal P75748 http://www.proteinmodelportal.org/query/uniprot/P75748 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415244 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415244 RefSeq WP_001272410 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001272410 STRING 511145.b0716 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0716&targetmode=cogs SUPFAM SSF49401 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49401 UniProtKB YBGO_ECOLI http://www.uniprot.org/uniprot/YBGO_ECOLI UniProtKB-AC P75748 http://www.uniprot.org/uniprot/P75748 charge swissprot:YBGO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBGO_ECOLI eggNOG ENOG4108MY7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MY7 eggNOG ENOG4110VJC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4110VJC epestfind swissprot:YBGO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBGO_ECOLI garnier swissprot:YBGO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBGO_ECOLI helixturnhelix swissprot:YBGO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBGO_ECOLI hmoment swissprot:YBGO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBGO_ECOLI iep swissprot:YBGO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBGO_ECOLI inforesidue swissprot:YBGO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBGO_ECOLI octanol swissprot:YBGO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBGO_ECOLI pepcoil swissprot:YBGO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBGO_ECOLI pepdigest swissprot:YBGO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBGO_ECOLI pepinfo swissprot:YBGO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBGO_ECOLI pepnet swissprot:YBGO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBGO_ECOLI pepstats swissprot:YBGO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBGO_ECOLI pepwheel swissprot:YBGO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBGO_ECOLI pepwindow swissprot:YBGO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBGO_ECOLI sigcleave swissprot:YBGO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBGO_ECOLI ## Database ID URL or Descriptions # EcoGene EG40008 insH11 # FUNCTION INH11_ECOLI Involved in the transposition of the insertion sequence IS5. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # InterPro IPR002559 Transposase_11 # InterPro IPR008490 Transposase_InsH_N # Organism INH11_ECOLI Escherichia coli (strain K12) # Pfam PF01609 DDE_Tnp_1 # Pfam PF05598 DUF772 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INH11_ECOLI Transposase InsH for insertion sequence element IS5T # RefSeq NP_414793 NC_000913.3 # RefSeq NP_415084 NC_000913.3 # RefSeq NP_415189 NC_000913.3 # RefSeq NP_415847 NC_000913.3 # RefSeq NP_416535 NC_000913.3 # RefSeq NP_416696 NC_000913.3 # RefSeq NP_417456 NC_000913.3 # RefSeq NP_417685 NC_000913.3 # RefSeq NP_417962 NC_000913.3 # SIMILARITY Belongs to the transposase 11 family. {ECO 0000305}. # eggNOG COG3039 LUCA # eggNOG ENOG4105F2I Bacteria BLAST swissprot:INH11_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INH11_ECOLI BioCyc EcoCyc:MONOMER0-4241 http://biocyc.org/getid?id=EcoCyc:MONOMER0-4241 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4742 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4742 EcoGene EG40008 http://www.ecogene.org/geneInfo.php?eg_id=EG40008 EnsemblBacteria AAC76530 http://www.ensemblgenomes.org/id/AAC76530 EnsemblBacteria AAC76530 http://www.ensemblgenomes.org/id/AAC76530 EnsemblBacteria BAE77789 http://www.ensemblgenomes.org/id/BAE77789 EnsemblBacteria BAE77789 http://www.ensemblgenomes.org/id/BAE77789 EnsemblBacteria BAE77789 http://www.ensemblgenomes.org/id/BAE77789 EnsemblBacteria b3505 http://www.ensemblgenomes.org/id/b3505 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GeneID 944917 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944917 GeneID 944941 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944941 GeneID 945896 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945896 GeneID 946163 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946163 GeneID 946577 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946577 GeneID 947516 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947516 GeneID 947743 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947743 GeneID 948015 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948015 GeneID 949121 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949121 InParanoid P0CE58 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CE58 InterPro IPR002559 http://www.ebi.ac.uk/interpro/entry/IPR002559 InterPro IPR008490 http://www.ebi.ac.uk/interpro/entry/IPR008490 KEGG_Gene ecj:JW3472 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3472 KEGG_Gene eco:b0259 http://www.genome.jp/dbget-bin/www_bget?eco:b0259 KEGG_Gene eco:b0552 http://www.genome.jp/dbget-bin/www_bget?eco:b0552 KEGG_Gene eco:b0656 http://www.genome.jp/dbget-bin/www_bget?eco:b0656 KEGG_Gene eco:b1331 http://www.genome.jp/dbget-bin/www_bget?eco:b1331 KEGG_Gene eco:b2030 http://www.genome.jp/dbget-bin/www_bget?eco:b2030 KEGG_Gene eco:b2192 http://www.genome.jp/dbget-bin/www_bget?eco:b2192 KEGG_Gene eco:b2982 http://www.genome.jp/dbget-bin/www_bget?eco:b2982 KEGG_Gene eco:b3218 http://www.genome.jp/dbget-bin/www_bget?eco:b3218 KEGG_Gene eco:b3505 http://www.genome.jp/dbget-bin/www_bget?eco:b3505 PSORT swissprot:INH11_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INH11_ECOLI PSORT-B swissprot:INH11_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INH11_ECOLI PSORT2 swissprot:INH11_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INH11_ECOLI Pfam PF01609 http://pfam.xfam.org/family/PF01609 Pfam PF05598 http://pfam.xfam.org/family/PF05598 Phobius swissprot:INH11_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INH11_ECOLI PhylomeDB P0CE58 http://phylomedb.org/?seqid=P0CE58 ProteinModelPortal P0CE58 http://www.proteinmodelportal.org/query/uniprot/P0CE58 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414793 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414793 RefSeq NP_415084 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415084 RefSeq NP_415189 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415189 RefSeq NP_415847 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415847 RefSeq NP_416535 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416535 RefSeq NP_416696 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416696 RefSeq NP_417456 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417456 RefSeq NP_417685 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417685 RefSeq NP_417962 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417962 SMR P0CE58 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0CE58 STRING 511145.b3505 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3505&targetmode=cogs UniProtKB INH11_ECOLI http://www.uniprot.org/uniprot/INH11_ECOLI UniProtKB-AC P0CE58 http://www.uniprot.org/uniprot/P0CE58 charge swissprot:INH11_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INH11_ECOLI eggNOG COG3039 http://eggnogapi.embl.de/nog_data/html/tree/COG3039 eggNOG ENOG4105F2I http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F2I epestfind swissprot:INH11_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INH11_ECOLI garnier swissprot:INH11_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INH11_ECOLI helixturnhelix swissprot:INH11_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INH11_ECOLI hmoment swissprot:INH11_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INH11_ECOLI iep swissprot:INH11_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INH11_ECOLI inforesidue swissprot:INH11_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INH11_ECOLI octanol swissprot:INH11_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INH11_ECOLI pepcoil swissprot:INH11_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INH11_ECOLI pepdigest swissprot:INH11_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INH11_ECOLI pepinfo swissprot:INH11_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INH11_ECOLI pepnet swissprot:INH11_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INH11_ECOLI pepstats swissprot:INH11_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INH11_ECOLI pepwheel swissprot:INH11_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INH11_ECOLI pepwindow swissprot:INH11_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INH11_ECOLI sigcleave swissprot:INH11_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INH11_ECOLI ## Database ID URL or Descriptions # AltName (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB {ECO:0000255|HAMAP-Rule MF_01864} # AltName tRNA-i(6)A37 methylthiotransferase {ECO:0000255|HAMAP-Rule MF_01864} # BRENDA 2.8.4 2026 # BioGrid 4261232 10 # CATALYTIC ACTIVITY N(6)-dimethylallyladenine(37) in tRNA + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine + reduced electron acceptor = 2-methylthio-N(6)-dimethylallyladenine(37) in tRNA + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine + electron acceptor. {ECO:0000255|HAMAP- Rule MF_01864}. # COFACTOR MIAB_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000305|PubMed 11882645}; Note=Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. {ECO 0000305|PubMed 11882645}; # EcoGene EG13657 miaB # FUNCTION MIAB_ECOLI Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. {ECO 0000255|HAMAP-Rule MF_01864, ECO 0000269|PubMed 10572129}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0005506 iron ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0035597 N6-isopentenyladenosine methylthiotransferase activity; IDA:EcoCyc. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IDA:EcoCyc. # GO_process GO:0030488 tRNA methylation; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # Gene3D 3.80.30.20 -; 1. # HAMAP MF_01864 tRNA_metthiotr_MiaB # IntAct P0AEI1 13 # InterPro IPR002792 TRAM_dom # InterPro IPR005839 Methylthiotransferase # InterPro IPR006463 MiaB_methiolase # InterPro IPR006638 Elp3/MiaB/NifB # InterPro IPR007197 rSAM # InterPro IPR013848 Methylthiotransferase_N # InterPro IPR020612 Methylthiotransferase_CS # InterPro IPR023404 rSAM_horseshoe # InterPro IPR023970 MeThioTfrase/rSAM # KEGG_Brite ko03016 Transfer RNA biogenesis # Organism MIAB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11918 PTHR11918 # PATRIC 32116511 VBIEscCol129921_0695 # PIR C64801 C64801 # PROSITE PS01278 MTTASE_RADICAL # PROSITE PS50926 TRAM # PROSITE PS51449 MTTASE_N # Pfam PF00919 UPF0004 # Pfam PF01938 TRAM # Pfam PF04055 Radical_SAM # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase {ECO:0000255|HAMAP-Rule MF_01864} # RefSeq NP_415194 NC_000913.3 # RefSeq WP_000162740 NZ_LN832404.1 # SIMILARITY Belongs to the methylthiotransferase family. MiaB subfamily. {ECO:0000255|HAMAP-Rule MF_01864}. # SIMILARITY Contains 1 MTTase N-terminal domain. {ECO:0000255|HAMAP-Rule MF_01864}. # SIMILARITY Contains 1 TRAM domain. {ECO:0000255|HAMAP- Rule MF_01864}. # SMART SM00729 Elp3 # SUBCELLULAR LOCATION MIAB_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_01864}. # SUBUNIT MIAB_ECOLI Monomer. {ECO 0000255|HAMAP-Rule MF_01864, ECO 0000269|PubMed 11882645}. # TIGRFAMs TIGR00089 TIGR00089 # eggNOG COG0621 LUCA # eggNOG ENOG4105CIW Bacteria BLAST swissprot:MIAB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MIAB_ECOLI BioCyc ECOL316407:JW0658-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0658-MONOMER BioCyc EcoCyc:G6364-MONOMER http://biocyc.org/getid?id=EcoCyc:G6364-MONOMER BioCyc MetaCyc:G6364-MONOMER http://biocyc.org/getid?id=MetaCyc:G6364-MONOMER COG COG0621 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0621 DIP DIP-48018N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48018N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.C100609200 http://dx.doi.org/10.1074/jbc.C100609200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.8.4.3 {ECO:0000255|HAMAP-Rule:MF_01864} http://www.genome.jp/dbget-bin/www_bget?EC:2.8.4.3 {ECO:0000255|HAMAP-Rule:MF_01864} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 ENZYME 2.8.4.3 {ECO:0000255|HAMAP-Rule:MF_01864} http://enzyme.expasy.org/EC/2.8.4.3 {ECO:0000255|HAMAP-Rule:MF_01864} EchoBASE EB3421 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3421 EcoGene EG13657 http://www.ecogene.org/geneInfo.php?eg_id=EG13657 EnsemblBacteria AAC73762 http://www.ensemblgenomes.org/id/AAC73762 EnsemblBacteria AAC73762 http://www.ensemblgenomes.org/id/AAC73762 EnsemblBacteria BAE76357 http://www.ensemblgenomes.org/id/BAE76357 EnsemblBacteria BAE76357 http://www.ensemblgenomes.org/id/BAE76357 EnsemblBacteria BAE76357 http://www.ensemblgenomes.org/id/BAE76357 EnsemblBacteria b0661 http://www.ensemblgenomes.org/id/b0661 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0035597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035597 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0030488 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030488 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 Gene3D 3.80.30.20 http://www.cathdb.info/version/latest/superfamily/3.80.30.20 GeneID 945260 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945260 HAMAP MF_01864 http://hamap.expasy.org/unirule/MF_01864 HOGENOM HOG000224767 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000224767&db=HOGENOM6 InParanoid P0AEI1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEI1 IntAct P0AEI1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEI1* IntEnz 2.8.4.3 {ECO:0000255|HAMAP-Rule:MF_01864} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.8.4.3 {ECO:0000255|HAMAP-Rule:MF_01864} InterPro IPR002792 http://www.ebi.ac.uk/interpro/entry/IPR002792 InterPro IPR005839 http://www.ebi.ac.uk/interpro/entry/IPR005839 InterPro IPR006463 http://www.ebi.ac.uk/interpro/entry/IPR006463 InterPro IPR006638 http://www.ebi.ac.uk/interpro/entry/IPR006638 InterPro IPR007197 http://www.ebi.ac.uk/interpro/entry/IPR007197 InterPro IPR013848 http://www.ebi.ac.uk/interpro/entry/IPR013848 InterPro IPR020612 http://www.ebi.ac.uk/interpro/entry/IPR020612 InterPro IPR023404 http://www.ebi.ac.uk/interpro/entry/IPR023404 InterPro IPR023970 http://www.ebi.ac.uk/interpro/entry/IPR023970 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW0658 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0658 KEGG_Gene eco:b0661 http://www.genome.jp/dbget-bin/www_bget?eco:b0661 KEGG_Orthology KO:K06168 http://www.genome.jp/dbget-bin/www_bget?KO:K06168 MINT MINT-1233637 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1233637 OMA IPMDLIL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IPMDLIL PANTHER PTHR11918 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11918 PROSITE PS01278 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01278 PROSITE PS50926 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50926 PROSITE PS51449 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51449 PSORT swissprot:MIAB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MIAB_ECOLI PSORT-B swissprot:MIAB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MIAB_ECOLI PSORT2 swissprot:MIAB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MIAB_ECOLI Pfam PF00919 http://pfam.xfam.org/family/PF00919 Pfam PF01938 http://pfam.xfam.org/family/PF01938 Pfam PF04055 http://pfam.xfam.org/family/PF04055 Phobius swissprot:MIAB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MIAB_ECOLI PhylomeDB P0AEI1 http://phylomedb.org/?seqid=P0AEI1 ProteinModelPortal P0AEI1 http://www.proteinmodelportal.org/query/uniprot/P0AEI1 PubMed 10572129 http://www.ncbi.nlm.nih.gov/pubmed/10572129 PubMed 11882645 http://www.ncbi.nlm.nih.gov/pubmed/11882645 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415194 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415194 RefSeq WP_000162740 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000162740 SMART SM00729 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00729 SMR P0AEI1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEI1 STRING 511145.b0661 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0661&targetmode=cogs STRING COG0621 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0621&targetmode=cogs TIGRFAMs TIGR00089 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00089 UniProtKB MIAB_ECOLI http://www.uniprot.org/uniprot/MIAB_ECOLI UniProtKB-AC P0AEI1 http://www.uniprot.org/uniprot/P0AEI1 charge swissprot:MIAB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MIAB_ECOLI eggNOG COG0621 http://eggnogapi.embl.de/nog_data/html/tree/COG0621 eggNOG ENOG4105CIW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CIW epestfind swissprot:MIAB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MIAB_ECOLI garnier swissprot:MIAB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MIAB_ECOLI helixturnhelix swissprot:MIAB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MIAB_ECOLI hmoment swissprot:MIAB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MIAB_ECOLI iep swissprot:MIAB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MIAB_ECOLI inforesidue swissprot:MIAB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MIAB_ECOLI octanol swissprot:MIAB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MIAB_ECOLI pepcoil swissprot:MIAB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MIAB_ECOLI pepdigest swissprot:MIAB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MIAB_ECOLI pepinfo swissprot:MIAB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MIAB_ECOLI pepnet swissprot:MIAB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MIAB_ECOLI pepstats swissprot:MIAB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MIAB_ECOLI pepwheel swissprot:MIAB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MIAB_ECOLI pepwindow swissprot:MIAB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MIAB_ECOLI sigcleave swissprot:MIAB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MIAB_ECOLI ## Database ID URL or Descriptions # AltName KUP_ECOLI Kup system potassium uptake protein # BioGrid 4263467 7 # EcoGene EG11541 kup # FUNCTION KUP_ECOLI Responsible for the low-affinity transport of potassium into the cell, with the probable concomitant uptake of protons (symport system). Can also transport cesium. {ECO 0000269|PubMed 10214935, ECO 0000269|PubMed 11682179, ECO 0000269|PubMed 2649491}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015079 potassium ion transmembrane transporter activity; IMP:EcoCyc. # GO_function GO:0015293 symporter activity; IEA:UniProtKB-HAMAP. # GO_process GO:0006813 potassium ion transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # HAMAP MF_01522 Kup # InterPro IPR003855 K+_transporter # InterPro IPR023051 K+_uptake_low_affin # KEGG_Brite ko02000 Transporters # MISCELLANEOUS KUP_ECOLI Kup is probably the major potassium uptake system upon hyper-osmotic stress at a low pH. # MISCELLANEOUS KUP_ECOLI Uptake is inhibited by protonophores such as CCCP. # Organism KUP_ECOLI Escherichia coli (strain K12) # PATRIC 32122993 VBIEscCol129921_3872 # PIR A49345 A49345 # Pfam PF02705 K_trans # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName KUP_ECOLI Low affinity potassium transport system protein kup # RefSeq WP_000102319 NZ_LN832404.1 # RefSeq YP_026244 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA62100.1; Type=Frameshift; Positions=506, 542, 579; Evidence={ECO 0000305}; # SIMILARITY Belongs to the HAK/KUP transporter (TC 2.A.72) family. {ECO 0000305}. # SUBCELLULAR LOCATION KUP_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # TCDB 2.A.72.1 the k(+) uptake permease (kup) family # TIGRFAMs TIGR00794 kup # eggNOG COG3158 LUCA # eggNOG ENOG4105DFH Bacteria BLAST swissprot:KUP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:KUP_ECOLI BioCyc ECOL316407:JW5609-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5609-MONOMER BioCyc EcoCyc:KUP-MONOMER http://biocyc.org/getid?id=EcoCyc:KUP-MONOMER BioCyc MetaCyc:KUP-MONOMER http://biocyc.org/getid?id=MetaCyc:KUP-MONOMER COG COG3158 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3158 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1016/S0014-5793(99)00288-4 http://dx.doi.org/10.1016/S0014-5793(99)00288-4 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1111/j.1574-6968.2001.tb10863.x http://dx.doi.org/10.1111/j.1574-6968.2001.tb10863.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X68551 http://www.ebi.ac.uk/ena/data/view/X68551 EchoBASE EB1503 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1503 EcoGene EG11541 http://www.ecogene.org/geneInfo.php?eg_id=EG11541 EnsemblBacteria AAT48204 http://www.ensemblgenomes.org/id/AAT48204 EnsemblBacteria AAT48204 http://www.ensemblgenomes.org/id/AAT48204 EnsemblBacteria BAE77541 http://www.ensemblgenomes.org/id/BAE77541 EnsemblBacteria BAE77541 http://www.ensemblgenomes.org/id/BAE77541 EnsemblBacteria BAE77541 http://www.ensemblgenomes.org/id/BAE77541 EnsemblBacteria b3747 http://www.ensemblgenomes.org/id/b3747 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015079 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015079 GO_function GO:0015293 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293 GO_process GO:0006813 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948255 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948255 HAMAP MF_01522 http://hamap.expasy.org/unirule/MF_01522 HOGENOM HOG000218033 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218033&db=HOGENOM6 InParanoid P63183 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P63183 InterPro IPR003855 http://www.ebi.ac.uk/interpro/entry/IPR003855 InterPro IPR023051 http://www.ebi.ac.uk/interpro/entry/IPR023051 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5609 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5609 KEGG_Gene eco:b3747 http://www.genome.jp/dbget-bin/www_bget?eco:b3747 KEGG_Orthology KO:K03549 http://www.genome.jp/dbget-bin/www_bget?KO:K03549 OMA ISYVMRA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ISYVMRA PSORT swissprot:KUP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:KUP_ECOLI PSORT-B swissprot:KUP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:KUP_ECOLI PSORT2 swissprot:KUP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:KUP_ECOLI Pfam PF02705 http://pfam.xfam.org/family/PF02705 Phobius swissprot:KUP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:KUP_ECOLI PhylomeDB P63183 http://phylomedb.org/?seqid=P63183 ProteinModelPortal P63183 http://www.proteinmodelportal.org/query/uniprot/P63183 PubMed 10214935 http://www.ncbi.nlm.nih.gov/pubmed/10214935 PubMed 11682179 http://www.ncbi.nlm.nih.gov/pubmed/11682179 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2649491 http://www.ncbi.nlm.nih.gov/pubmed/2649491 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 8226635 http://www.ncbi.nlm.nih.gov/pubmed/8226635 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000102319 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000102319 RefSeq YP_026244 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026244 STRING 511145.b3747 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3747&targetmode=cogs STRING COG3158 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3158&targetmode=cogs TCDB 2.A.72.1 http://www.tcdb.org/search/result.php?tc=2.A.72.1 TIGRFAMs TIGR00794 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00794 UniProtKB KUP_ECOLI http://www.uniprot.org/uniprot/KUP_ECOLI UniProtKB-AC P63183 http://www.uniprot.org/uniprot/P63183 charge swissprot:KUP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:KUP_ECOLI eggNOG COG3158 http://eggnogapi.embl.de/nog_data/html/tree/COG3158 eggNOG ENOG4105DFH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DFH epestfind swissprot:KUP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:KUP_ECOLI garnier swissprot:KUP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:KUP_ECOLI helixturnhelix swissprot:KUP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:KUP_ECOLI hmoment swissprot:KUP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:KUP_ECOLI iep swissprot:KUP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:KUP_ECOLI inforesidue swissprot:KUP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:KUP_ECOLI octanol swissprot:KUP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:KUP_ECOLI pepcoil swissprot:KUP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:KUP_ECOLI pepdigest swissprot:KUP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:KUP_ECOLI pepinfo swissprot:KUP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:KUP_ECOLI pepnet swissprot:KUP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:KUP_ECOLI pepstats swissprot:KUP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:KUP_ECOLI pepwheel swissprot:KUP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:KUP_ECOLI pepwindow swissprot:KUP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:KUP_ECOLI sigcleave swissprot:KUP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:KUP_ECOLI ## Database ID URL or Descriptions # AltName MNGB_ECOLI 2-O-(6-phospho-mannosyl)-D-glycerate hydrolase # AltName MNGB_ECOLI Alpha-mannosidase mngB # BioGrid 4263542 12 # CATALYTIC ACTIVITY 2-O-(6-phospho-alpha-D-mannosyl)-D-glycerate + H(2)O = D-mannose 6-phosphate + D-glycerate. {ECO:0000269|PubMed 14645248}. # CAZy GH38 Glycoside Hydrolase Family 38 # COFACTOR MNGB_ECOLI Name=a divalent metal cation; Xref=ChEBI CHEBI 60240; Evidence={ECO 0000250}; Note=Binds 1 divalent metal cation per subunit. {ECO 0000250}; # EcoGene EG13236 mngB # FUNCTION MNGB_ECOLI May hydrolyze mannosyl-D-glycerate to mannose-6- phosphate and glycerate. {ECO 0000269|PubMed 14645248}. # GO_function GO:0004559 alpha-mannosidase activity; IMP:EcoliWiki. # GO_function GO:0008270 zinc ion binding; IEA:InterPro. # GO_function GO:0030246 carbohydrate binding; IEA:InterPro. # GO_process GO:0006013 mannose metabolic process; IBA:GO_Central. # GO_process GO:0006517 protein deglycosylation; IBA:GO_Central. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.20.1270.50 -; 1. # Gene3D 3.20.110.10 -; 1. # INDUCTION MNGB_ECOLI Repressed by MngR. Induced by mannosyl-D-glycerate. # IntAct P54746 14 # InterPro IPR000602 Glyco_hydro_38_N # InterPro IPR011013 Gal_mutarotase_SF_dom # InterPro IPR011330 Glyco_hydro/deAcase_b/a-brl # InterPro IPR011682 Glyco_hydro_38_C # InterPro IPR015341 Glyco_hydro_38_cen # InterPro IPR027291 Glyco_hydro_38/57_N # InterPro IPR028995 Glyco_hydro_57/38_cen # KEGG_Brite ko01000 Enzymes # Organism MNGB_ECOLI Escherichia coli (strain K12) # PATRIC 32116659 VBIEscCol129921_0762 # PIR C64809 C64809 # Pfam PF01074 Glyco_hydro_38 # Pfam PF07748 Glyco_hydro_38C # Pfam PF09261 Alpha-mann_mid # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MNGB_ECOLI Mannosylglycerate hydrolase # RefSeq NP_415260 NC_000913.3 # RefSeq WP_000648976 NZ_LN832404.1 # SIMILARITY Belongs to the glycosyl hydrolase 38 family. {ECO 0000305}. # SMART SM00872 Alpha-mann_mid # SUPFAM SSF74650 SSF74650 # SUPFAM SSF88688 SSF88688 # SUPFAM SSF88713 SSF88713 # eggNOG COG0383 LUCA # eggNOG ENOG4105C8I Bacteria BLAST swissprot:MNGB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MNGB_ECOLI BioCyc ECOL316407:JW0721-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0721-MONOMER BioCyc EcoCyc:EG13236-MONOMER http://biocyc.org/getid?id=EcoCyc:EG13236-MONOMER BioCyc MetaCyc:EG13236-MONOMER http://biocyc.org/getid?id=MetaCyc:EG13236-MONOMER COG CAZy: http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=CAZy: COG COG0383 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0383 COG GH38 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=GH38 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M310980200 http://dx.doi.org/10.1074/jbc.M310980200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1271/bbb.60.309 http://dx.doi.org/10.1271/bbb.60.309 EC_number EC:3.2.1.170 http://www.genome.jp/dbget-bin/www_bget?EC:3.2.1.170 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D64014 http://www.ebi.ac.uk/ena/data/view/D64014 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.2.1.170 http://enzyme.expasy.org/EC/3.2.1.170 EchoBASE EB3025 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3025 EcoGene EG13236 http://www.ecogene.org/geneInfo.php?eg_id=EG13236 EnsemblBacteria AAC73826 http://www.ensemblgenomes.org/id/AAC73826 EnsemblBacteria AAC73826 http://www.ensemblgenomes.org/id/AAC73826 EnsemblBacteria BAA35398 http://www.ensemblgenomes.org/id/BAA35398 EnsemblBacteria BAA35398 http://www.ensemblgenomes.org/id/BAA35398 EnsemblBacteria BAA35398 http://www.ensemblgenomes.org/id/BAA35398 EnsemblBacteria b0732 http://www.ensemblgenomes.org/id/b0732 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004559 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004559 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0030246 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030246 GO_process GO:0006013 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006013 GO_process GO:0006517 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006517 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.20.1270.50 http://www.cathdb.info/version/latest/superfamily/1.20.1270.50 Gene3D 3.20.110.10 http://www.cathdb.info/version/latest/superfamily/3.20.110.10 GeneID 945359 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945359 HOGENOM HOG000231434 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231434&db=HOGENOM6 InParanoid P54746 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P54746 IntAct P54746 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P54746* IntEnz 3.2.1.170 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.2.1.170 InterPro IPR000602 http://www.ebi.ac.uk/interpro/entry/IPR000602 InterPro IPR011013 http://www.ebi.ac.uk/interpro/entry/IPR011013 InterPro IPR011330 http://www.ebi.ac.uk/interpro/entry/IPR011330 InterPro IPR011682 http://www.ebi.ac.uk/interpro/entry/IPR011682 InterPro IPR015341 http://www.ebi.ac.uk/interpro/entry/IPR015341 InterPro IPR027291 http://www.ebi.ac.uk/interpro/entry/IPR027291 InterPro IPR028995 http://www.ebi.ac.uk/interpro/entry/IPR028995 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0721 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0721 KEGG_Gene eco:b0732 http://www.genome.jp/dbget-bin/www_bget?eco:b0732 KEGG_Orthology KO:K15524 http://www.genome.jp/dbget-bin/www_bget?KO:K15524 OMA LENTDRY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LENTDRY PSORT swissprot:MNGB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MNGB_ECOLI PSORT-B swissprot:MNGB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MNGB_ECOLI PSORT2 swissprot:MNGB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MNGB_ECOLI Pfam PF01074 http://pfam.xfam.org/family/PF01074 Pfam PF07748 http://pfam.xfam.org/family/PF07748 Pfam PF09261 http://pfam.xfam.org/family/PF09261 Phobius swissprot:MNGB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MNGB_ECOLI PhylomeDB P54746 http://phylomedb.org/?seqid=P54746 ProteinModelPortal P54746 http://www.proteinmodelportal.org/query/uniprot/P54746 PubMed 14645248 http://www.ncbi.nlm.nih.gov/pubmed/14645248 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9063979 http://www.ncbi.nlm.nih.gov/pubmed/9063979 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415260 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415260 RefSeq WP_000648976 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000648976 SMART SM00872 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00872 SMR P54746 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P54746 STRING 511145.b0732 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0732&targetmode=cogs STRING CAZy: http://string-db.org/newstring_cgi/show_network_section.pl?identifier=CAZy:&targetmode=cogs STRING COG0383 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0383&targetmode=cogs STRING GH38 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=GH38&targetmode=cogs SUPFAM SSF74650 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF74650 SUPFAM SSF88688 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF88688 SUPFAM SSF88713 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF88713 UniProtKB MNGB_ECOLI http://www.uniprot.org/uniprot/MNGB_ECOLI UniProtKB-AC P54746 http://www.uniprot.org/uniprot/P54746 charge swissprot:MNGB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MNGB_ECOLI eggNOG COG0383 http://eggnogapi.embl.de/nog_data/html/tree/COG0383 eggNOG ENOG4105C8I http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C8I epestfind swissprot:MNGB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MNGB_ECOLI garnier swissprot:MNGB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MNGB_ECOLI helixturnhelix swissprot:MNGB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MNGB_ECOLI hmoment swissprot:MNGB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MNGB_ECOLI iep swissprot:MNGB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MNGB_ECOLI inforesidue swissprot:MNGB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MNGB_ECOLI octanol swissprot:MNGB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MNGB_ECOLI pepcoil swissprot:MNGB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MNGB_ECOLI pepdigest swissprot:MNGB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MNGB_ECOLI pepinfo swissprot:MNGB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MNGB_ECOLI pepnet swissprot:MNGB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MNGB_ECOLI pepstats swissprot:MNGB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MNGB_ECOLI pepwheel swissprot:MNGB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MNGB_ECOLI pepwindow swissprot:MNGB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MNGB_ECOLI sigcleave swissprot:MNGB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MNGB_ECOLI ## Database ID URL or Descriptions # BioGrid 4263374 9 # CAUTION Was originally thought to be a tagatose 6-phosphate kinase. {ECO:0000305|PubMed 8932697}. # EcoGene EG12763 kbaZ # FUNCTION KBAZ_ECOLI Component of the tagatose-1,6-bisphosphate aldolase KbaYZ that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of KbaY. When expressed alone, KbaZ does not show any aldolase activity. {ECO 0000269|PubMed 11976750}. # GO_function GO:0003824 catalytic activity; IEA:InterPro. # GO_process GO:0019402 galactitol metabolic process; IEA:InterPro. # GO_process GO:2001059 D-tagatose 6-phosphate catabolic process; IEA:UniProtKB-UniPathway. # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.70 -; 1. # HAMAP MF_01295 Tagatose_aldol_KbaZ # IntAct P0C8K0 7 # InterPro IPR012062 TagBP_ald_GatZ/KbaZ # InterPro IPR013785 Aldolase_TIM # InterPro IPR023435 TagBP_ald_KbaZ # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko00052 Galactose metabolism # MISCELLANEOUS KBAZ_ECOLI In contrast to E.coli strains C and EC3132, K-12 strains cannot grow on N-acetylgalactosamine and D-galactosamine, because they carry a deletion and thus lack active PTS systems specific for these compounds. Therefore, KbaYZ in K-12 strains is not involved in the degradation of these compounds. # Organism KBAZ_ECOLI Escherichia coli (strain K12) # PATHWAY Carbohydrate metabolism; D-tagatose 6-phosphate degradation; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate step 2/2. # PATRIC 32121680 VBIEscCol129921_3226 # PIR H65102 H65102 # PIRSF PIRSF009264 TagBP_ald_AgaZ # Pfam PF08013 Tagatose_6_P_K # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName KBAZ_ECOLI D-tagatose-1,6-bisphosphate aldolase subunit KbaZ # RefSeq NP_417601 NC_000913.3 # RefSeq WP_000681920 NZ_LN832404.1 # SIMILARITY Belongs to the GatZ/KbaZ family. KbaZ subfamily. {ECO 0000305}. # SUBUNIT KBAZ_ECOLI Forms a complex with KbaY. # TIGRFAMs TIGR02810 agaZ_gatZ # UniPathway UPA00704 UER00716 # eggNOG COG4573 LUCA # eggNOG ENOG4105C6Q Bacteria BLAST swissprot:KBAZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:KBAZ_ECOLI BioCyc EcoCyc:G7631-MONOMER http://biocyc.org/getid?id=EcoCyc:G7631-MONOMER BioCyc MetaCyc:G7631-MONOMER http://biocyc.org/getid?id=MetaCyc:G7631-MONOMER COG COG4573 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4573 DIP DIP-9075N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9075N DOI 10.1007/s00203-002-0406-6 http://dx.doi.org/10.1007/s00203-002-0406-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1099/13500872-142-2-231 http://dx.doi.org/10.1099/13500872-142-2-231 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2616 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2616 EcoGene EG12763 http://www.ecogene.org/geneInfo.php?eg_id=EG12763 EnsemblBacteria AAC76166 http://www.ensemblgenomes.org/id/AAC76166 EnsemblBacteria AAC76166 http://www.ensemblgenomes.org/id/AAC76166 EnsemblBacteria BAE77179 http://www.ensemblgenomes.org/id/BAE77179 EnsemblBacteria BAE77179 http://www.ensemblgenomes.org/id/BAE77179 EnsemblBacteria BAE77179 http://www.ensemblgenomes.org/id/BAE77179 EnsemblBacteria b3132 http://www.ensemblgenomes.org/id/b3132 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003824 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003824 GO_process GO:0019402 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019402 GO_process GO:2001059 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2001059 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 947637 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947637 HAMAP MF_01295 http://hamap.expasy.org/unirule/MF_01295 HOGENOM HOG000263918 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000263918&db=HOGENOM6 InParanoid P0C8K0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0C8K0 IntAct P0C8K0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0C8K0* InterPro IPR012062 http://www.ebi.ac.uk/interpro/entry/IPR012062 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR023435 http://www.ebi.ac.uk/interpro/entry/IPR023435 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW3101 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3101 KEGG_Gene eco:b3132 http://www.genome.jp/dbget-bin/www_bget?eco:b3132 KEGG_Orthology KO:K16371 http://www.genome.jp/dbget-bin/www_bget?KO:K16371 KEGG_Pathway ko00052 http://www.genome.jp/kegg-bin/show_pathway?ko00052 KEGG_Reaction rn:R01069 http://www.genome.jp/dbget-bin/www_bget?rn:R01069 OMA GPNPWKH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GPNPWKH PSORT swissprot:KBAZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:KBAZ_ECOLI PSORT-B swissprot:KBAZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:KBAZ_ECOLI PSORT2 swissprot:KBAZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:KBAZ_ECOLI Pfam PF08013 http://pfam.xfam.org/family/PF08013 Phobius swissprot:KBAZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:KBAZ_ECOLI PhylomeDB P0C8K0 http://phylomedb.org/?seqid=P0C8K0 ProteinModelPortal P0C8K0 http://www.proteinmodelportal.org/query/uniprot/P0C8K0 PubMed 11976750 http://www.ncbi.nlm.nih.gov/pubmed/11976750 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8932697 http://www.ncbi.nlm.nih.gov/pubmed/8932697 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417601 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417601 RefSeq WP_000681920 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000681920 SMR P0C8K0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0C8K0 STRING 511145.b3132 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3132&targetmode=cogs STRING COG4573 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4573&targetmode=cogs TIGRFAMs TIGR02810 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02810 UniProtKB KBAZ_ECOLI http://www.uniprot.org/uniprot/KBAZ_ECOLI UniProtKB-AC P0C8K0 http://www.uniprot.org/uniprot/P0C8K0 charge swissprot:KBAZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:KBAZ_ECOLI eggNOG COG4573 http://eggnogapi.embl.de/nog_data/html/tree/COG4573 eggNOG ENOG4105C6Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C6Q epestfind swissprot:KBAZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:KBAZ_ECOLI garnier swissprot:KBAZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:KBAZ_ECOLI helixturnhelix swissprot:KBAZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:KBAZ_ECOLI hmoment swissprot:KBAZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:KBAZ_ECOLI iep swissprot:KBAZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:KBAZ_ECOLI inforesidue swissprot:KBAZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:KBAZ_ECOLI octanol swissprot:KBAZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:KBAZ_ECOLI pepcoil swissprot:KBAZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:KBAZ_ECOLI pepdigest swissprot:KBAZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:KBAZ_ECOLI pepinfo swissprot:KBAZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:KBAZ_ECOLI pepnet swissprot:KBAZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:KBAZ_ECOLI pepstats swissprot:KBAZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:KBAZ_ECOLI pepwheel swissprot:KBAZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:KBAZ_ECOLI pepwindow swissprot:KBAZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:KBAZ_ECOLI sigcleave swissprot:KBAZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:KBAZ_ECOLI ## Database ID URL or Descriptions # EcoGene EG13398 ylbE # Gene3D 1.10.10.660 -; 1. # IntAct P77129 6 # InterPro IPR009499 DUF1116 # InterPro IPR024033 Uncharacterised_dom_YlbE # Organism YLBE_ECOLI Escherichia coli (strain K12) # PIR F64783 F64783 # Pfam PF06545 DUF1116 # Proteomes UP000000625 Chromosome # RecName YLBE_ECOLI Uncharacterized protein YlbE # RefSeq WP_000495367 NZ_LN832404.1 # RefSeq YP_009029994 NC_000913.3 # SIMILARITY To E.coli YahG. {ECO 0000305}. # eggNOG ENOG4107REC Bacteria # eggNOG ENOG410XPNV LUCA BLAST swissprot:YLBE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YLBE_ECOLI BioCyc EcoCyc:G6288-MONOMER http://biocyc.org/getid?id=EcoCyc:G6288-MONOMER DOI 10.1007/BF00290367 http://dx.doi.org/10.1007/BF00290367 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL D42020 http://www.ebi.ac.uk/ena/data/view/D42020 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EchoBASE EB3179 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3179 EcoGene EG13398 http://www.ecogene.org/geneInfo.php?eg_id=EG13398 EnsemblBacteria ABD18638 http://www.ensemblgenomes.org/id/ABD18638 EnsemblBacteria ABD18638 http://www.ensemblgenomes.org/id/ABD18638 EnsemblBacteria b4572 http://www.ensemblgenomes.org/id/b4572 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 1.10.10.660 http://www.cathdb.info/version/latest/superfamily/1.10.10.660 GeneID 4056025 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4056025 HOGENOM HOG000077993 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000077993&db=HOGENOM6 IntAct P77129 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77129* InterPro IPR009499 http://www.ebi.ac.uk/interpro/entry/IPR009499 InterPro IPR024033 http://www.ebi.ac.uk/interpro/entry/IPR024033 KEGG_Gene eco:b4572 http://www.genome.jp/dbget-bin/www_bget?eco:b4572 OMA MNEGIGK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MNEGIGK PSORT swissprot:YLBE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YLBE_ECOLI PSORT-B swissprot:YLBE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YLBE_ECOLI PSORT2 swissprot:YLBE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YLBE_ECOLI Pfam PF06545 http://pfam.xfam.org/family/PF06545 Phobius swissprot:YLBE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YLBE_ECOLI ProteinModelPortal P77129 http://www.proteinmodelportal.org/query/uniprot/P77129 PubMed 7500942 http://www.ncbi.nlm.nih.gov/pubmed/7500942 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000495367 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000495367 RefSeq YP_009029994 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009029994 SMR P77129 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77129 STRING 316385.ECDH10B_0475 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316385.ECDH10B_0475&targetmode=cogs UniProtKB YLBE_ECOLI http://www.uniprot.org/uniprot/YLBE_ECOLI UniProtKB-AC P77129 http://www.uniprot.org/uniprot/P77129 charge swissprot:YLBE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YLBE_ECOLI eggNOG ENOG4107REC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107REC eggNOG ENOG410XPNV http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPNV epestfind swissprot:YLBE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YLBE_ECOLI garnier swissprot:YLBE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YLBE_ECOLI helixturnhelix swissprot:YLBE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YLBE_ECOLI hmoment swissprot:YLBE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YLBE_ECOLI iep swissprot:YLBE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YLBE_ECOLI inforesidue swissprot:YLBE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YLBE_ECOLI octanol swissprot:YLBE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YLBE_ECOLI pepcoil swissprot:YLBE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YLBE_ECOLI pepdigest swissprot:YLBE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YLBE_ECOLI pepinfo swissprot:YLBE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YLBE_ECOLI pepnet swissprot:YLBE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YLBE_ECOLI pepstats swissprot:YLBE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YLBE_ECOLI pepwheel swissprot:YLBE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YLBE_ECOLI pepwindow swissprot:YLBE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YLBE_ECOLI sigcleave swissprot:YLBE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YLBE_ECOLI ## Database ID URL or Descriptions # BioGrid 4259559 174 # EcoGene EG12529 bdcR # FUNCTION BDCR_ECOLI Negatively regulates expression of bdcA. {ECO 0000269|PubMed 21059164}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0000976 transcription regulatory region sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IBA:GO_Central. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.60 -; 1. # Gene3D 1.10.357.10 -; 1. # InterPro IPR001647 HTH_TetR # InterPro IPR009057 Homeodomain-like # InterPro IPR011075 Tet_transcr_reg_TetR-rel_C # InterPro IPR015893 Tet_transcr_reg_TetR-like_C # InterPro IPR023772 DNA-bd_HTH_TetR-type_CS # Organism BDCR_ECOLI Escherichia coli (strain K12) # PATRIC 32124073 VBIEscCol129921_4381 # PIR S56476 S56476 # PROSITE PS01081 HTH_TETR_1 # PROSITE PS50977 HTH_TETR_2 # Pfam PF00440 TetR_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BDCR_ECOLI HTH-type transcriptional repressor BdcR # RefSeq NP_418672 NC_000913.3 # RefSeq WP_000256658 NZ_LN832404.1 # SIMILARITY Contains 1 HTH tetR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00335}. # SUPFAM SSF46689 SSF46689 # SUPFAM SSF48498 SSF48498 # eggNOG ENOG4108XFH Bacteria # eggNOG ENOG4111MNX LUCA BLAST swissprot:BDCR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BDCR_ECOLI BioCyc ECOL316407:JW4208-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4208-MONOMER BioCyc EcoCyc:G7882-MONOMER http://biocyc.org/getid?id=EcoCyc:G7882-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1111/j.1462-2920.2010.02368.x http://dx.doi.org/10.1111/j.1462-2920.2010.02368.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2419 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2419 EcoGene EG12529 http://www.ecogene.org/geneInfo.php?eg_id=EG12529 EnsemblBacteria AAC77208 http://www.ensemblgenomes.org/id/AAC77208 EnsemblBacteria AAC77208 http://www.ensemblgenomes.org/id/AAC77208 EnsemblBacteria BAE78248 http://www.ensemblgenomes.org/id/BAE78248 EnsemblBacteria BAE78248 http://www.ensemblgenomes.org/id/BAE78248 EnsemblBacteria BAE78248 http://www.ensemblgenomes.org/id/BAE78248 EnsemblBacteria b4251 http://www.ensemblgenomes.org/id/b4251 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000976 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000976 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 Gene3D 1.10.357.10 http://www.cathdb.info/version/latest/superfamily/1.10.357.10 GeneID 948775 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948775 HOGENOM HOG000161265 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000161265&db=HOGENOM6 InParanoid P39334 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39334 IntAct P39334 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39334* InterPro IPR001647 http://www.ebi.ac.uk/interpro/entry/IPR001647 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR011075 http://www.ebi.ac.uk/interpro/entry/IPR011075 InterPro IPR015893 http://www.ebi.ac.uk/interpro/entry/IPR015893 InterPro IPR023772 http://www.ebi.ac.uk/interpro/entry/IPR023772 KEGG_Gene ecj:JW4208 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4208 KEGG_Gene eco:b4251 http://www.genome.jp/dbget-bin/www_bget?eco:b4251 OMA NDAQARE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NDAQARE PROSITE PS01081 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01081 PROSITE PS50977 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50977 PSORT swissprot:BDCR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BDCR_ECOLI PSORT-B swissprot:BDCR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BDCR_ECOLI PSORT2 swissprot:BDCR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BDCR_ECOLI Pfam PF00440 http://pfam.xfam.org/family/PF00440 Phobius swissprot:BDCR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BDCR_ECOLI PhylomeDB P39334 http://phylomedb.org/?seqid=P39334 ProteinModelPortal P39334 http://www.proteinmodelportal.org/query/uniprot/P39334 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21059164 http://www.ncbi.nlm.nih.gov/pubmed/21059164 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418672 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418672 RefSeq WP_000256658 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000256658 SMR P39334 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39334 STRING 511145.b4251 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4251&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF48498 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48498 UniProtKB BDCR_ECOLI http://www.uniprot.org/uniprot/BDCR_ECOLI UniProtKB-AC P39334 http://www.uniprot.org/uniprot/P39334 charge swissprot:BDCR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BDCR_ECOLI eggNOG ENOG4108XFH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108XFH eggNOG ENOG4111MNX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111MNX epestfind swissprot:BDCR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BDCR_ECOLI garnier swissprot:BDCR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BDCR_ECOLI helixturnhelix swissprot:BDCR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BDCR_ECOLI hmoment swissprot:BDCR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BDCR_ECOLI iep swissprot:BDCR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BDCR_ECOLI inforesidue swissprot:BDCR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BDCR_ECOLI octanol swissprot:BDCR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BDCR_ECOLI pepcoil swissprot:BDCR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BDCR_ECOLI pepdigest swissprot:BDCR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BDCR_ECOLI pepinfo swissprot:BDCR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BDCR_ECOLI pepnet swissprot:BDCR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BDCR_ECOLI pepstats swissprot:BDCR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BDCR_ECOLI pepwheel swissprot:BDCR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BDCR_ECOLI pepwindow swissprot:BDCR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BDCR_ECOLI sigcleave swissprot:BDCR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BDCR_ECOLI ## Database ID URL or Descriptions # BioGrid 4259246 6 # DISRUPTION PHENOTYPE Cells grow better in the presence of the bile acid deoxycholate. Increased membrane stability when incubated for 2 hours in the presence of 4.5% deoxycholate. Increased cell survival in the presence of 20% deoxycholate. {ECO:0000269|PubMed 25534751}. # EcoGene EG13021 ygiS # FUNCTION YGIS_ECOLI Probably part of a deoxycholate transport system. Its expression in the presence of deoxycholate in a ygiS deletion mutant increases intracellular deoxycholate levels and decreases cell growth; higher expression in the presence of deoxycholate inhibits cell growth completely. Bile acid detergents such as deoxycholate are important for host defense against bacterial growth in the gall bladder and duodenum. {ECO 0000269|PubMed 25534751}. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IEA:InterPro. # GO_function GO:0015197 peptide transporter activity; IBA:GO_Central. # GO_process GO:0055085 transmembrane transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0055085 transmembrane transport # INDUCTION Repressed by the toxin-antitoxin system MqsR-MqsA; this mRNA is degraded by mRNA interferase MqsR. {ECO:0000269|PubMed 25534751}. # InterPro IPR000914 SBP_5_dom # InterPro IPR030678 Peptide/Ni-bd # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00239 Peptides/nickel transport system # KEGG_Brite ko02000 Transporters # Organism YGIS_ECOLI Escherichia coli (strain K12) # PATRIC 32121454 VBIEscCol129921_3114 # PIR B65089 B65089 # PIRSF PIRSF002741 MppA # Pfam PF00496 SBP_bac_5 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGIS_ECOLI Probable deoxycholate-binding periplasmic protein YgiS # RefSeq NP_417492 NC_000913.3 # RefSeq WP_001295629 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial solute-binding protein 5 family. {ECO 0000305}. # SUBCELLULAR LOCATION YGIS_ECOLI Periplasm {ECO 0000305|PubMed 25534751}. # TCDB 3.A.1.5.41 the atp-binding cassette (abc) superfamily # eggNOG COG4166 LUCA # eggNOG ENOG4108J59 Bacteria BLAST swissprot:YGIS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGIS_ECOLI BioCyc ECOL316407:JW2988-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2988-MONOMER BioCyc EcoCyc:YGIS-MONOMER http://biocyc.org/getid?id=EcoCyc:YGIS-MONOMER COG COG0747 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0747 DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/1462-2920.12749 http://dx.doi.org/10.1111/1462-2920.12749 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2839 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2839 EcoGene EG13021 http://www.ecogene.org/geneInfo.php?eg_id=EG13021 EnsemblBacteria AAC76056 http://www.ensemblgenomes.org/id/AAC76056 EnsemblBacteria AAC76056 http://www.ensemblgenomes.org/id/AAC76056 EnsemblBacteria BAE77076 http://www.ensemblgenomes.org/id/BAE77076 EnsemblBacteria BAE77076 http://www.ensemblgenomes.org/id/BAE77076 EnsemblBacteria BAE77076 http://www.ensemblgenomes.org/id/BAE77076 EnsemblBacteria b3020 http://www.ensemblgenomes.org/id/b3020 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0015197 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015197 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 947140 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947140 HOGENOM HOG000179191 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000179191&db=HOGENOM6 InParanoid Q46863 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46863 InterPro IPR000914 http://www.ebi.ac.uk/interpro/entry/IPR000914 InterPro IPR030678 http://www.ebi.ac.uk/interpro/entry/IPR030678 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2988 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2988 KEGG_Gene eco:b3020 http://www.genome.jp/dbget-bin/www_bget?eco:b3020 KEGG_Orthology KO:K02035 http://www.genome.jp/dbget-bin/www_bget?KO:K02035 OMA YYIELNI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YYIELNI PSORT swissprot:YGIS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGIS_ECOLI PSORT-B swissprot:YGIS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGIS_ECOLI PSORT2 swissprot:YGIS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGIS_ECOLI Pfam PF00496 http://pfam.xfam.org/family/PF00496 Phobius swissprot:YGIS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGIS_ECOLI PhylomeDB Q46863 http://phylomedb.org/?seqid=Q46863 ProteinModelPortal Q46863 http://www.proteinmodelportal.org/query/uniprot/Q46863 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 25534751 http://www.ncbi.nlm.nih.gov/pubmed/25534751 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417492 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417492 RefSeq WP_001295629 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295629 SMR Q46863 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46863 STRING 511145.b3020 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3020&targetmode=cogs STRING COG0747 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0747&targetmode=cogs TCDB 3.A.1.5.41 http://www.tcdb.org/search/result.php?tc=3.A.1.5.41 UniProtKB YGIS_ECOLI http://www.uniprot.org/uniprot/YGIS_ECOLI UniProtKB-AC Q46863 http://www.uniprot.org/uniprot/Q46863 charge swissprot:YGIS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGIS_ECOLI eggNOG COG4166 http://eggnogapi.embl.de/nog_data/html/tree/COG4166 eggNOG ENOG4108J59 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108J59 epestfind swissprot:YGIS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGIS_ECOLI garnier swissprot:YGIS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGIS_ECOLI helixturnhelix swissprot:YGIS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGIS_ECOLI hmoment swissprot:YGIS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGIS_ECOLI iep swissprot:YGIS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGIS_ECOLI inforesidue swissprot:YGIS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGIS_ECOLI octanol swissprot:YGIS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGIS_ECOLI pepcoil swissprot:YGIS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGIS_ECOLI pepdigest swissprot:YGIS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGIS_ECOLI pepinfo swissprot:YGIS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGIS_ECOLI pepnet swissprot:YGIS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGIS_ECOLI pepstats swissprot:YGIS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGIS_ECOLI pepwheel swissprot:YGIS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGIS_ECOLI pepwindow swissprot:YGIS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGIS_ECOLI sigcleave swissprot:YGIS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGIS_ECOLI ## Database ID URL or Descriptions # AltName RHMA_ECOLI 2-dehydro-3-deoxyrhamnonate aldolase # AltName RHMA_ECOLI 2-keto-3-deoxy acid sugar aldolase # BIOPHYSICOCHEMICAL PROPERTIES RHMA_ECOLI Kinetic parameters KM=0.078 mM for 2-keto-3-deoxy-L-rhamnonate (in the presence of magnesium) {ECO 0000269|PubMed 18754683}; KM=0.14 mM for 2-keto-3-deoxy-L-mannonate (in the presence of magnesium) {ECO 0000269|PubMed 18754683}; KM=0.8 mM for 2-keto-3-deoxy-L-lyxonate (in the presence of magnesium) {ECO 0000269|PubMed 18754683}; KM=0.15 mM for 4-hydroxy-2-ketoheptane-1,7-dioate (in the presence of magnesium) {ECO 0000269|PubMed 18754683}; KM=0.1 mM for 4-hydroxy-2-ketoheptane-1,7-dioate (in the presence of nickel) {ECO 0000269|PubMed 18754683}; KM=0.1 mM for 4-hydroxy-2-ketopentanoate (in the presence of nickel) {ECO 0000269|PubMed 18754683}; KM=0.05 mM for 4-hydroxy-2-ketohexanoate (in the presence of nickel) {ECO 0000269|PubMed 18754683}; Note=The catalytic efficiency observed with HKHD as substrate is 750-fold higher with Ni(2+) as cofactor than that with Mg(2+) as cofactor. 4-hydroxy-2-keto-5-phenyl-pentanoate and 4-hydroxy-2- keto-6-phenylhexanoate are not substrates, suggesting a requirement for an aliphatic or less bulky distal end of the substrate.; # BRENDA 4.1.2.53 2026 # BioGrid 4261484 18 # CATALYTIC ACTIVITY RHMA_ECOLI 2-dehydro-3-deoxy-L-rhamnonate = pyruvate + (S)-lactaldehyde. # COFACTOR RHMA_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 18754683}; Name=Ni(2+); Xref=ChEBI CHEBI 49786; Evidence={ECO 0000269|PubMed 18754683}; Note=Binds 1 Mg(2+) ion per subunit. Is more efficient when using Ni(2+) ion, although it is not likely to be the physiologically relevant active site metal. {ECO 0000269|PubMed 18754683}; # EcoGene EG14083 rhmA # FUNCTION RHMA_ECOLI Catalyzes the reversible retro-aldol cleavage of 2-keto- 3-deoxy-L-rhamnonate (KDR) to pyruvate and lactaldehyde. 2-keto-3- deoxy-L-mannonate, 2-keto-3-deoxy-L-lyxonate and 4-hydroxy-2- ketoheptane-1,7-dioate (HKHD) are also reasonably good substrates, although 2-keto-3-deoxy-L-rhamnonate is likely to be the physiological substrate. {ECO 0000269|PubMed 18754683, ECO 0000269|PubMed 18754693}. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0016151 nickel cation binding; IDA:EcoliWiki. # GO_function GO:0016832 aldehyde-lyase activity; IDA:EcoCyc. # GO_process GO:0005975 carbohydrate metabolic process; IBA:GO_Central. # GO_process GO:0006725 cellular aromatic compound metabolic process; ISS:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0008150 biological_process # Gene3D 3.20.20.60 -; 1. # HAMAP MF_01290 KDR_aldolase # InterPro IPR005000 Aldolase/citrate-lyase_domain # InterPro IPR015813 Pyrv/PenolPyrv_Kinase-like_dom # InterPro IPR023593 KDR_aldolase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00051 Fructose and mannose metabolism # Organism RHMA_ECOLI Escherichia coli (strain K12) # PATRIC 32119853 VBIEscCol129921_2336 # PDB 2VWS X-ray; 1.39 A; A/B/C=1-267 # PDB 2VWT X-ray; 1.93 A; A/B/C=1-267 # PIR C64995 C64995 # Pfam PF03328 HpcH_HpaI # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RHMA_ECOLI 2-keto-3-deoxy-L-rhamnonate aldolase # RefSeq NP_416748 NC_000913.3 # RefSeq WP_000992954 NZ_LN832404.1 # SIMILARITY Belongs to the HpcH/HpaI aldolase family. KDR aldolase subfamily. {ECO 0000305}. # SUBUNIT Homohexamer. {ECO:0000269|PubMed 18754683}. # SUPFAM SSF51621 SSF51621 # eggNOG COG3836 LUCA # eggNOG ENOG4105CNV Bacteria BLAST swissprot:RHMA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RHMA_ECOLI BioCyc ECOL316407:JW2239-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2239-MONOMER BioCyc EcoCyc:G7158-MONOMER http://biocyc.org/getid?id=EcoCyc:G7158-MONOMER BioCyc MetaCyc:G7158-MONOMER http://biocyc.org/getid?id=MetaCyc:G7158-MONOMER COG COG3836 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3836 DIP DIP-11953N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11953N DOI 10.1021/bi800914r http://dx.doi.org/10.1021/bi800914r DOI 10.1021/bi800943g http://dx.doi.org/10.1021/bi800943g DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1107/S0907444902017894 http://dx.doi.org/10.1107/S0907444902017894 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.1.2.53 http://www.genome.jp/dbget-bin/www_bget?EC:4.1.2.53 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 4.1.2.53 http://enzyme.expasy.org/EC/4.1.2.53 EchoBASE EB3836 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3836 EcoGene EG14083 http://www.ecogene.org/geneInfo.php?eg_id=EG14083 EnsemblBacteria AAC75305 http://www.ensemblgenomes.org/id/AAC75305 EnsemblBacteria AAC75305 http://www.ensemblgenomes.org/id/AAC75305 EnsemblBacteria BAA16064 http://www.ensemblgenomes.org/id/BAA16064 EnsemblBacteria BAA16064 http://www.ensemblgenomes.org/id/BAA16064 EnsemblBacteria BAA16064 http://www.ensemblgenomes.org/id/BAA16064 EnsemblBacteria b2245 http://www.ensemblgenomes.org/id/b2245 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0016151 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016151 GO_function GO:0016832 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016832 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GO_process GO:0006725 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006725 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.20.20.60 http://www.cathdb.info/version/latest/superfamily/3.20.20.60 GeneID 948054 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948054 HAMAP MF_01290 http://hamap.expasy.org/unirule/MF_01290 HOGENOM HOG000179750 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000179750&db=HOGENOM6 InParanoid P76469 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76469 IntEnz 4.1.2.53 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.2.53 InterPro IPR005000 http://www.ebi.ac.uk/interpro/entry/IPR005000 InterPro IPR015813 http://www.ebi.ac.uk/interpro/entry/IPR015813 InterPro IPR023593 http://www.ebi.ac.uk/interpro/entry/IPR023593 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2239 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2239 KEGG_Gene eco:b2245 http://www.genome.jp/dbget-bin/www_bget?eco:b2245 KEGG_Orthology KO:K12660 http://www.genome.jp/dbget-bin/www_bget?KO:K12660 KEGG_Pathway ko00051 http://www.genome.jp/kegg-bin/show_pathway?ko00051 KEGG_Reaction rn:R02261 http://www.genome.jp/dbget-bin/www_bget?rn:R02261 OMA IARASQW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IARASQW PDB 2VWS http://www.ebi.ac.uk/pdbe-srv/view/entry/2VWS PDB 2VWT http://www.ebi.ac.uk/pdbe-srv/view/entry/2VWT PDBsum 2VWS http://www.ebi.ac.uk/pdbsum/2VWS PDBsum 2VWT http://www.ebi.ac.uk/pdbsum/2VWT PSORT swissprot:RHMA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RHMA_ECOLI PSORT-B swissprot:RHMA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RHMA_ECOLI PSORT2 swissprot:RHMA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RHMA_ECOLI Pfam PF03328 http://pfam.xfam.org/family/PF03328 Phobius swissprot:RHMA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RHMA_ECOLI PhylomeDB P76469 http://phylomedb.org/?seqid=P76469 ProteinModelPortal P76469 http://www.proteinmodelportal.org/query/uniprot/P76469 PubMed 12454498 http://www.ncbi.nlm.nih.gov/pubmed/12454498 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18754683 http://www.ncbi.nlm.nih.gov/pubmed/18754683 PubMed 18754693 http://www.ncbi.nlm.nih.gov/pubmed/18754693 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416748 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416748 RefSeq WP_000992954 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000992954 SMR P76469 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76469 STRING 511145.b2245 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2245&targetmode=cogs STRING COG3836 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3836&targetmode=cogs SUPFAM SSF51621 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51621 UniProtKB RHMA_ECOLI http://www.uniprot.org/uniprot/RHMA_ECOLI UniProtKB-AC P76469 http://www.uniprot.org/uniprot/P76469 charge swissprot:RHMA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RHMA_ECOLI eggNOG COG3836 http://eggnogapi.embl.de/nog_data/html/tree/COG3836 eggNOG ENOG4105CNV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CNV epestfind swissprot:RHMA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RHMA_ECOLI garnier swissprot:RHMA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RHMA_ECOLI helixturnhelix swissprot:RHMA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RHMA_ECOLI hmoment swissprot:RHMA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RHMA_ECOLI iep swissprot:RHMA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RHMA_ECOLI inforesidue swissprot:RHMA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RHMA_ECOLI octanol swissprot:RHMA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RHMA_ECOLI pepcoil swissprot:RHMA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RHMA_ECOLI pepdigest swissprot:RHMA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RHMA_ECOLI pepinfo swissprot:RHMA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RHMA_ECOLI pepnet swissprot:RHMA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RHMA_ECOLI pepstats swissprot:RHMA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RHMA_ECOLI pepwheel swissprot:RHMA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RHMA_ECOLI pepwindow swissprot:RHMA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RHMA_ECOLI sigcleave swissprot:RHMA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RHMA_ECOLI ## Database ID URL or Descriptions # BioGrid 4263473 10 # EcoGene EG11786 yfiF # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003723 RNA binding; IBA:GO_Central. # GO_function GO:0070039 rRNA (guanosine-2'-O-)-methyltransferase activity; IBA:GO_Central. # GO_process GO:0000453 enzyme-directed rRNA 2'-O-methylation; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.30.1330.30 -; 1. # Gene3D 3.40.1280.10 -; 1. # IntAct P0AGJ5 75 # InterPro IPR001537 SpoU_MeTrfase # InterPro IPR013123 SpoU_subst-bd # InterPro IPR016479 YfiF_prd # InterPro IPR029026 tRNA_m1G_MTases_N # InterPro IPR029028 Alpha/beta_knot_MTases # InterPro IPR029064 L30e-like # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # KEGG_Brite ko03016 Transfer RNA biogenesis # Organism YFIF_ECOLI Escherichia coli (strain K12) # PATRIC 32120563 VBIEscCol129921_2684 # PIR D65036 D65036 # PIRSF PIRSF006280 YfiF_prd # Pfam PF00588 SpoU_methylase # Pfam PF08032 SpoU_sub_bind # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFIF_ECOLI Uncharacterized tRNA/rRNA methyltransferase YfiF # RefSeq NP_417076 NC_000913.3 # RefSeq WP_000997403 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=D13169; Type=Frameshift; Positions=331; Evidence={ECO 0000305}; # SIMILARITY Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. {ECO 0000305}. # SMART SM00967 SpoU_sub_bind # SUPFAM SSF55315 SSF55315 # SUPFAM SSF75217 SSF75217 # eggNOG COG0566 LUCA # eggNOG ENOG4105EIB Bacteria BLAST swissprot:YFIF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFIF_ECOLI BioCyc ECOL316407:JW2565-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2565-MONOMER BioCyc EcoCyc:EG11786-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11786-MONOMER COG COG0566 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0566 DIP DIP-47835N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47835N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/nar/21.23.5519 http://dx.doi.org/10.1093/nar/21.23.5519 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D13169 http://www.ebi.ac.uk/ena/data/view/D13169 EMBL J03725 http://www.ebi.ac.uk/ena/data/view/J03725 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.1.1.- http://enzyme.expasy.org/EC/2.1.1.- EchoBASE EB1734 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1734 EcoGene EG11786 http://www.ecogene.org/geneInfo.php?eg_id=EG11786 EnsemblBacteria AAC75634 http://www.ensemblgenomes.org/id/AAC75634 EnsemblBacteria AAC75634 http://www.ensemblgenomes.org/id/AAC75634 EnsemblBacteria BAA16467 http://www.ensemblgenomes.org/id/BAA16467 EnsemblBacteria BAA16467 http://www.ensemblgenomes.org/id/BAA16467 EnsemblBacteria BAA16467 http://www.ensemblgenomes.org/id/BAA16467 EnsemblBacteria b2581 http://www.ensemblgenomes.org/id/b2581 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0070039 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070039 GO_process GO:0000453 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000453 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.30.1330.30 http://www.cathdb.info/version/latest/superfamily/3.30.1330.30 Gene3D 3.40.1280.10 http://www.cathdb.info/version/latest/superfamily/3.40.1280.10 GeneID 947066 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947066 HOGENOM HOG000218800 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218800&db=HOGENOM6 InParanoid P0AGJ5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGJ5 IntAct P0AGJ5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AGJ5* IntEnz 2.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1 InterPro IPR001537 http://www.ebi.ac.uk/interpro/entry/IPR001537 InterPro IPR013123 http://www.ebi.ac.uk/interpro/entry/IPR013123 InterPro IPR016479 http://www.ebi.ac.uk/interpro/entry/IPR016479 InterPro IPR029026 http://www.ebi.ac.uk/interpro/entry/IPR029026 InterPro IPR029028 http://www.ebi.ac.uk/interpro/entry/IPR029028 InterPro IPR029064 http://www.ebi.ac.uk/interpro/entry/IPR029064 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW2565 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2565 KEGG_Gene eco:b2581 http://www.genome.jp/dbget-bin/www_bget?eco:b2581 KEGG_Orthology KO:K03214 http://www.genome.jp/dbget-bin/www_bget?KO:K03214 MINT MINT-1218417 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1218417 OMA IVRLWAT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IVRLWAT PSORT swissprot:YFIF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFIF_ECOLI PSORT-B swissprot:YFIF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFIF_ECOLI PSORT2 swissprot:YFIF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFIF_ECOLI Pfam PF00588 http://pfam.xfam.org/family/PF00588 Pfam PF08032 http://pfam.xfam.org/family/PF08032 Phobius swissprot:YFIF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFIF_ECOLI PhylomeDB P0AGJ5 http://phylomedb.org/?seqid=P0AGJ5 ProteinModelPortal P0AGJ5 http://www.proteinmodelportal.org/query/uniprot/P0AGJ5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2836397 http://www.ncbi.nlm.nih.gov/pubmed/2836397 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 8265370 http://www.ncbi.nlm.nih.gov/pubmed/8265370 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417076 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417076 RefSeq WP_000997403 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000997403 SMART SM00967 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00967 SMR P0AGJ5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AGJ5 STRING 511145.b2581 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2581&targetmode=cogs STRING COG0566 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0566&targetmode=cogs SUPFAM SSF55315 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55315 SUPFAM SSF75217 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF75217 UniProtKB YFIF_ECOLI http://www.uniprot.org/uniprot/YFIF_ECOLI UniProtKB-AC P0AGJ5 http://www.uniprot.org/uniprot/P0AGJ5 charge swissprot:YFIF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFIF_ECOLI eggNOG COG0566 http://eggnogapi.embl.de/nog_data/html/tree/COG0566 eggNOG ENOG4105EIB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EIB epestfind swissprot:YFIF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFIF_ECOLI garnier swissprot:YFIF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFIF_ECOLI helixturnhelix swissprot:YFIF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFIF_ECOLI hmoment swissprot:YFIF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFIF_ECOLI iep swissprot:YFIF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFIF_ECOLI inforesidue swissprot:YFIF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFIF_ECOLI octanol swissprot:YFIF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFIF_ECOLI pepcoil swissprot:YFIF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFIF_ECOLI pepdigest swissprot:YFIF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFIF_ECOLI pepinfo swissprot:YFIF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFIF_ECOLI pepnet swissprot:YFIF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFIF_ECOLI pepstats swissprot:YFIF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFIF_ECOLI pepwheel swissprot:YFIF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFIF_ECOLI pepwindow swissprot:YFIF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFIF_ECOLI sigcleave swissprot:YFIF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFIF_ECOLI ## Database ID URL or Descriptions # BRENDA 2.1.2 2026 # CATALYTIC ACTIVITY FMT_ECOLI 10-formyltetrahydrofolate + L-methionyl- tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet). # DOMAIN FMT_ECOLI Composed of an N- and a C-terminal domain. The N-terminal domain carries the tetrahydrofolate (THF)-binding site and the C- terminal domain is presumably involved in positioning the Met-tRNA substrate for the formylation reaction. # EcoGene EG11268 fmt # FUNCTION FMT_ECOLI Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004479 methionyl-tRNA formyltransferase activity; IDA:EcoCyc. # GO_process GO:0019988 charged-tRNA amino acid modification; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0006464 cellular protein modification process # Gene3D 3.10.25.10 -; 1. # Gene3D 3.40.50.170 -; 1. # HAMAP MF_00182 Formyl_trans # IntAct P23882 12 # InterPro IPR001555 GART_AS # InterPro IPR002376 Formyl_transf_N # InterPro IPR005793 Formyl_trans_C # InterPro IPR005794 Fmt # InterPro IPR011034 Formyl_transferase_C-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00670 One carbon pool by folate # KEGG_Pathway ko00970 Aminoacyl-tRNA biosynthesis # Organism FMT_ECOLI Escherichia coli (strain K12) # PATRIC 32122008 VBIEscCol129921_3381 # PDB 1FMT X-ray; 2.00 A; A/B=2-315 # PDB 2FMT X-ray; 2.80 A; A/B=2-315 # PIR S23108 S23108 # PROSITE PS00373 GART # Pfam PF00551 Formyl_trans_N # Pfam PF02911 Formyl_trans_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FMT_ECOLI Methionyl-tRNA formyltransferase # RefSeq NP_417746 NC_000913.3 # RefSeq WP_000004473 NZ_LN832404.1 # SIMILARITY Belongs to the Fmt family. {ECO 0000305}. # SUBUNIT FMT_ECOLI Monomer. # SUPFAM SSF50486 SSF50486 # SUPFAM SSF53328 SSF53328 # TIGRFAMs TIGR00460 fmt # eggNOG COG0223 LUCA # eggNOG ENOG4105CAE Bacteria BLAST swissprot:FMT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FMT_ECOLI BioCyc ECOL316407:JW3249-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3249-MONOMER BioCyc EcoCyc:EG11268-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11268-MONOMER BioCyc MetaCyc:EG11268-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11268-MONOMER COG COG0223 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0223 DIP DIP-9668N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9668N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/jmbi.1996.0835 http://dx.doi.org/10.1006/jmbi.1996.0835 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/emboj/17.23.6819 http://dx.doi.org/10.1093/emboj/17.23.6819 DOI 10.1093/nar/12.14.5813 http://dx.doi.org/10.1093/nar/12.14.5813 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.2.9 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.2.9 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X00767 http://www.ebi.ac.uk/ena/data/view/X00767 EMBL X63666 http://www.ebi.ac.uk/ena/data/view/X63666 EMBL X77091 http://www.ebi.ac.uk/ena/data/view/X77091 EMBL Y10307 http://www.ebi.ac.uk/ena/data/view/Y10307 ENZYME 2.1.2.9 http://enzyme.expasy.org/EC/2.1.2.9 EchoBASE EB1247 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1247 EcoGene EG11268 http://www.ecogene.org/geneInfo.php?eg_id=EG11268 EnsemblBacteria AAC76313 http://www.ensemblgenomes.org/id/AAC76313 EnsemblBacteria AAC76313 http://www.ensemblgenomes.org/id/AAC76313 EnsemblBacteria BAE78004 http://www.ensemblgenomes.org/id/BAE78004 EnsemblBacteria BAE78004 http://www.ensemblgenomes.org/id/BAE78004 EnsemblBacteria BAE78004 http://www.ensemblgenomes.org/id/BAE78004 EnsemblBacteria b3288 http://www.ensemblgenomes.org/id/b3288 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004479 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004479 GO_process GO:0019988 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019988 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 Gene3D 3.10.25.10 http://www.cathdb.info/version/latest/superfamily/3.10.25.10 Gene3D 3.40.50.170 http://www.cathdb.info/version/latest/superfamily/3.40.50.170 GeneID 947779 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947779 HAMAP MF_00182 http://hamap.expasy.org/unirule/MF_00182 HOGENOM HOG000261177 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261177&db=HOGENOM6 InParanoid P23882 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23882 IntAct P23882 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P23882* IntEnz 2.1.2.9 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.2.9 InterPro IPR001555 http://www.ebi.ac.uk/interpro/entry/IPR001555 InterPro IPR002376 http://www.ebi.ac.uk/interpro/entry/IPR002376 InterPro IPR005793 http://www.ebi.ac.uk/interpro/entry/IPR005793 InterPro IPR005794 http://www.ebi.ac.uk/interpro/entry/IPR005794 InterPro IPR011034 http://www.ebi.ac.uk/interpro/entry/IPR011034 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3249 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3249 KEGG_Gene eco:b3288 http://www.genome.jp/dbget-bin/www_bget?eco:b3288 KEGG_Orthology KO:K00604 http://www.genome.jp/dbget-bin/www_bget?KO:K00604 KEGG_Pathway ko00670 http://www.genome.jp/kegg-bin/show_pathway?ko00670 KEGG_Pathway ko00970 http://www.genome.jp/kegg-bin/show_pathway?ko00970 KEGG_Reaction rn:R03940 http://www.genome.jp/dbget-bin/www_bget?rn:R03940 OMA GCINSHA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GCINSHA PDB 1FMT http://www.ebi.ac.uk/pdbe-srv/view/entry/1FMT PDB 2FMT http://www.ebi.ac.uk/pdbe-srv/view/entry/2FMT PDBsum 1FMT http://www.ebi.ac.uk/pdbsum/1FMT PDBsum 2FMT http://www.ebi.ac.uk/pdbsum/2FMT PROSITE PS00373 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00373 PSORT swissprot:FMT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FMT_ECOLI PSORT-B swissprot:FMT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FMT_ECOLI PSORT2 swissprot:FMT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FMT_ECOLI Pfam PF00551 http://pfam.xfam.org/family/PF00551 Pfam PF02911 http://pfam.xfam.org/family/PF02911 Phobius swissprot:FMT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FMT_ECOLI PhylomeDB P23882 http://phylomedb.org/?seqid=P23882 ProteinModelPortal P23882 http://www.proteinmodelportal.org/query/uniprot/P23882 PubMed 1624424 http://www.ncbi.nlm.nih.gov/pubmed/1624424 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6379605 http://www.ncbi.nlm.nih.gov/pubmed/6379605 PubMed 8112305 http://www.ncbi.nlm.nih.gov/pubmed/8112305 PubMed 8432722 http://www.ncbi.nlm.nih.gov/pubmed/8432722 PubMed 8887566 http://www.ncbi.nlm.nih.gov/pubmed/8887566 PubMed 9086272 http://www.ncbi.nlm.nih.gov/pubmed/9086272 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9843487 http://www.ncbi.nlm.nih.gov/pubmed/9843487 RefSeq NP_417746 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417746 RefSeq WP_000004473 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000004473 SMR P23882 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P23882 STRING 511145.b3288 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3288&targetmode=cogs STRING COG0223 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0223&targetmode=cogs SUPFAM SSF50486 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50486 SUPFAM SSF53328 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53328 SWISS-2DPAGE P23882 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P23882 TIGRFAMs TIGR00460 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00460 UniProtKB FMT_ECOLI http://www.uniprot.org/uniprot/FMT_ECOLI UniProtKB-AC P23882 http://www.uniprot.org/uniprot/P23882 charge swissprot:FMT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FMT_ECOLI eggNOG COG0223 http://eggnogapi.embl.de/nog_data/html/tree/COG0223 eggNOG ENOG4105CAE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CAE epestfind swissprot:FMT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FMT_ECOLI garnier swissprot:FMT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FMT_ECOLI helixturnhelix swissprot:FMT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FMT_ECOLI hmoment swissprot:FMT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FMT_ECOLI iep swissprot:FMT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FMT_ECOLI inforesidue swissprot:FMT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FMT_ECOLI octanol swissprot:FMT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FMT_ECOLI pepcoil swissprot:FMT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FMT_ECOLI pepdigest swissprot:FMT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FMT_ECOLI pepinfo swissprot:FMT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FMT_ECOLI pepnet swissprot:FMT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FMT_ECOLI pepstats swissprot:FMT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FMT_ECOLI pepwheel swissprot:FMT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FMT_ECOLI pepwindow swissprot:FMT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FMT_ECOLI sigcleave swissprot:FMT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FMT_ECOLI ## Database ID URL or Descriptions # DOMAIN RL18_ECOLI The basic N-terminus is not necessary for binding to 5S rRNA. It is however required for cooperative binding of L5 and L18 to 5S rRNA as well as for binding of the 5S rRNA/L5/L18 complex to the 23S rRNA. {ECO 0000269|PubMed 353728}. # EcoGene EG10879 rplR # FUNCTION RL18_ECOLI This is one of the proteins that mediates the attachment of the 5S rRNA subcomplex onto the large ribosomal subunit where it forms part of the central protuberance. Binds stably to 5S rRNA; increases binding abilities of L5 in a cooperative fashion; both proteins together confer 23S rRNA binding. The 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. {ECO 0000269|PubMed 109811, ECO 0000269|PubMed 353728, ECO 0000269|PubMed 354687, ECO 0000269|PubMed 6159586, ECO 0000269|PubMed 7038683}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0022625 cytosolic large ribosomal subunit; IDA:EcoCyc. # GO_function GO:0003735 structural constituent of ribosome; IEA:InterPro. # GO_function GO:0008097 5S rRNA binding; IBA:GO_Central. # GO_process GO:0006412 translation; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_function GO:0019843 rRNA binding # GOslim_process GO:0006412 translation # HAMAP MF_01337_B Ribosomal_L18_B # IntAct P0C018 35 # InterPro IPR004389 Ribosomal_L18_bac-type # InterPro IPR005484 Ribosomal_L18 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 M00179 Ribosome, archaea # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=12769.8; Method=MALDI; Range=1-117; Evidence={ECO:0000269|PubMed 10094780}; # Organism RL18_ECOLI Escherichia coli (strain K12) # PATRIC 32122040 VBIEscCol129921_3397 # PDB 1ML5 EM; 14.00 A; q=2-117 # PDB 2J28 EM; 8.00 A; O=1-117 # PDB 2RDO EM; 9.10 A; O=1-117 # PDB 3BBX EM; 10.00 A; O=1-117 # PDB 3J5L EM; 6.60 A; O=2-117 # PDB 3J7Z EM; 3.90 A; O=1-117 # PDB 3J8G EM; 5.00 A; O=1-117 # PDB 3J9Y EM; 3.90 A; O=1-117 # PDB 3J9Z EM; 3.60 A; LK=1-117 # PDB 3JA1 EM; 3.60 A; LQ=1-117 # PDB 3JBU EM; 3.64 A; o=1-117 # PDB 3JBV EM; 3.32 A; o=1-117 # PDB 3JCD EM; 3.70 A; O=1-117 # PDB 3JCE EM; 3.20 A; O=1-117 # PDB 3JCJ EM; 3.70 A; N=1-117 # PDB 3JCN EM; 4.60 A; O=1-117 # PDB 4CSU EM; 5.50 A; O=2-117 # PDB 4U1U X-ray; 2.95 A; BO/DO=2-117 # PDB 4U1V X-ray; 3.00 A; BO/DO=2-117 # PDB 4U20 X-ray; 2.90 A; BO/DO=2-117 # PDB 4U24 X-ray; 2.90 A; BO/DO=2-117 # PDB 4U25 X-ray; 2.90 A; BO/DO=2-117 # PDB 4U26 X-ray; 2.80 A; BO/DO=2-117 # PDB 4U27 X-ray; 2.80 A; BO/DO=2-117 # PDB 4UY8 EM; 3.80 A; O=2-117 # PDB 4V47 EM; 12.30 A; AM=1-117 # PDB 4V48 EM; 11.50 A; AM=1-117 # PDB 4V4H X-ray; 3.46 A; BO/DO=1-117 # PDB 4V4Q X-ray; 3.46 A; BO/DO=1-117 # PDB 4V4V EM; 15.00 A; BM=3-115 # PDB 4V4W EM; 15.00 A; BM=3-115 # PDB 4V50 X-ray; 3.22 A; BO/DO=1-117 # PDB 4V52 X-ray; 3.21 A; BO/DO=1-117 # PDB 4V53 X-ray; 3.54 A; BO/DO=1-117 # PDB 4V54 X-ray; 3.30 A; BO/DO=1-117 # PDB 4V55 X-ray; 4.00 A; BO/DO=1-117 # PDB 4V56 X-ray; 3.93 A; BO/DO=1-117 # PDB 4V57 X-ray; 3.50 A; BO/DO=1-117 # PDB 4V5B X-ray; 3.74 A; AO/CO=1-117 # PDB 4V5H EM; 5.80 A; BO=2-117 # PDB 4V5Y X-ray; 4.45 A; BO/DO=1-117 # PDB 4V64 X-ray; 3.50 A; BO/DO=1-117 # PDB 4V65 EM; 9.00 A; BH=1-117 # PDB 4V66 EM; 9.00 A; BH=1-117 # PDB 4V69 EM; 6.70 A; BO=2-117 # PDB 4V6C X-ray; 3.19 A; BO/DO=1-117 # PDB 4V6D X-ray; 3.81 A; BO/DO=1-117 # PDB 4V6E X-ray; 3.71 A; BO/DO=1-117 # PDB 4V6K EM; 8.25 A; AP=1-117 # PDB 4V6L EM; 13.20 A; BP=1-117 # PDB 4V6M EM; 7.10 A; BO=1-117 # PDB 4V6N EM; 12.10 A; AQ=1-117 # PDB 4V6O EM; 14.70 A; BQ=1-117 # PDB 4V6P EM; 13.50 A; BQ=1-117 # PDB 4V6Q EM; 11.50 A; BQ=1-117 # PDB 4V6R EM; 11.50 A; BQ=1-117 # PDB 4V6S EM; 13.10 A; AQ=1-117 # PDB 4V6T EM; 8.30 A; BO=2-117 # PDB 4V6V EM; 9.80 A; BS=1-117 # PDB 4V6Y EM; 12.00 A; BO=1-117 # PDB 4V6Z EM; 12.00 A; BO=1-117 # PDB 4V70 EM; 17.00 A; BO=1-117 # PDB 4V71 EM; 20.00 A; BO=1-117 # PDB 4V72 EM; 13.00 A; BO=1-117 # PDB 4V73 EM; 15.00 A; BO=1-117 # PDB 4V74 EM; 17.00 A; BO=1-117 # PDB 4V75 EM; 12.00 A; BO=1-117 # PDB 4V76 EM; 17.00 A; BO=1-117 # PDB 4V77 EM; 17.00 A; BO=1-117 # PDB 4V78 EM; 20.00 A; BO=1-117 # PDB 4V79 EM; 15.00 A; BO=1-117 # PDB 4V7A EM; 9.00 A; BO=1-117 # PDB 4V7B EM; 6.80 A; BO=1-117 # PDB 4V7C EM; 7.60 A; BQ=1-117 # PDB 4V7D EM; 7.60 A; AR=1-117 # PDB 4V7I EM; 9.60 A; AO=1-117 # PDB 4V7S X-ray; 3.25 A; BO/DO=2-117 # PDB 4V7T X-ray; 3.19 A; BO/DO=2-117 # PDB 4V7U X-ray; 3.10 A; BO/DO=2-117 # PDB 4V7V X-ray; 3.29 A; BO/DO=2-117 # PDB 4V85 X-ray; 3.20 A; S=1-117 # PDB 4V89 X-ray; 3.70 A; BS=1-117 # PDB 4V9C X-ray; 3.30 A; BO/DO=1-117 # PDB 4V9D X-ray; 3.00 A; CO/DO=2-117 # PDB 4V9O X-ray; 2.90 A; AO/CO/EO/GO=1-117 # PDB 4V9P X-ray; 2.90 A; AO/CO/EO/GO=1-117 # PDB 4WF1 X-ray; 3.09 A; BO/DO=2-117 # PDB 4WOI X-ray; 3.00 A; BO/CO=1-117 # PDB 4WWW X-ray; 3.10 A; RO/YO=2-117 # PDB 4YBB X-ray; 2.10 A; CP/DP=1-117 # PDB 5ADY EM; 4.50 A; O=1-117 # PDB 5AFI EM; 2.90 A; O=1-117 # PDB 5AKA EM; 5.70 A; O=1-117 # PDB 5GAD EM; 3.70 A; P=1-117 # PDB 5GAE EM; 3.33 A; P=1-117 # PDB 5GAF EM; 4.30 A; P=1-117 # PDB 5GAG EM; 3.80 A; P=1-117 # PDB 5GAH EM; 3.80 A; P=1-117 # PDB 5IQR EM; 3.00 A; O=1-117 # PDB 5IT8 X-ray; 3.12 A; CP/DP=1-117 # PDB 5J5B X-ray; 2.80 A; CP/DP=1-117 # PDB 5J7L X-ray; 3.00 A; CP/DP=1-117 # PDB 5J88 X-ray; 3.32 A; CP/DP=1-117 # PDB 5J8A X-ray; 3.10 A; CP/DP=1-117 # PDB 5J91 X-ray; 2.96 A; CP/DP=1-117 # PDB 5JC9 X-ray; 3.03 A; CP/DP=1-117 # PDB 5JTE EM; 3.60 A; BO=1-117 # PDB 5JU8 EM; 3.60 A; BO=1-117 # PDB 5KCR EM; 3.60 A; 1S=1-117 # PDB 5KCS EM; 3.90 A; 1S=1-117 # PDB 5KPS EM; 3.90 A; O=1-117 # PDB 5KPV EM; 4.10 A; N=1-117 # PDB 5KPW EM; 3.90 A; N=1-117 # PDB 5KPX EM; 3.90 A; N=1-117 # PDB 5L3P EM; 3.70 A; S=1-117 # PIR A02803 R5EC18 # PTM RL18_ECOLI The protein has been shown to contain a phosphoserine, which was required for the protein to bind to 5S rRNA (PubMed 10529214). However, the presence of this phosphoserine is controversial, and it has not been seen by mass spectrometry. {ECO 0000269|PubMed 10529214}. # Pfam PF00861 Ribosomal_L18p # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RL18_ECOLI 50S ribosomal protein L18 # RefSeq NP_417763 NC_000913.3 # RefSeq WP_000358960 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein L18P family. {ECO 0000305}. # SUBUNIT RL18_ECOLI Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs. {ECO 0000269|PubMed 109811, ECO 0000269|PubMed 8925931}. # TIGRFAMs TIGR00060 L18_bact # eggNOG COG0256 LUCA BLAST swissprot:RL18_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RL18_ECOLI BioCyc ECOL316407:JW3266-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3266-MONOMER BioCyc EcoCyc:EG10879-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10879-MONOMER BioCyc MetaCyc:EG10879-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10879-MONOMER COG COG0256 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0256 DIP DIP-47908N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47908N DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1016/0014-5793(75)81127-6 http://dx.doi.org/10.1016/0014-5793(75)81127-6 DOI 10.1016/0014-5793(96)00872-1 http://dx.doi.org/10.1016/0014-5793(96)00872-1 DOI 10.1016/S0092-8674(03)00427-6 http://dx.doi.org/10.1016/S0092-8674(03)00427-6 DOI 10.1016/j.celrep.2014.09.011 http://dx.doi.org/10.1016/j.celrep.2014.09.011 DOI 10.1021/bi00606a002 http://dx.doi.org/10.1021/bi00606a002 DOI 10.1021/bi9914816 http://dx.doi.org/10.1021/bi9914816 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.79.3.729 http://dx.doi.org/10.1073/pnas.79.3.729 DOI 10.1093/nar/11.9.2599 http://dx.doi.org/10.1093/nar/11.9.2599 DOI 10.1093/nar/5.6.1753 http://dx.doi.org/10.1093/nar/5.6.1753 DOI 10.1093/nar/6.4.1669 http://dx.doi.org/10.1093/nar/6.4.1669 DOI 10.1093/nar/8.18.4131 http://dx.doi.org/10.1093/nar/8.18.4131 DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pbio.1001866 http://dx.doi.org/10.1371/journal.pbio.1001866 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X01563 http://www.ebi.ac.uk/ena/data/view/X01563 EchoBASE EB0872 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0872 EcoGene EG10879 http://www.ecogene.org/geneInfo.php?eg_id=EG10879 EnsemblBacteria AAC76329 http://www.ensemblgenomes.org/id/AAC76329 EnsemblBacteria AAC76329 http://www.ensemblgenomes.org/id/AAC76329 EnsemblBacteria BAE77987 http://www.ensemblgenomes.org/id/BAE77987 EnsemblBacteria BAE77987 http://www.ensemblgenomes.org/id/BAE77987 EnsemblBacteria BAE77987 http://www.ensemblgenomes.org/id/BAE77987 EnsemblBacteria b3304 http://www.ensemblgenomes.org/id/b3304 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0022625 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022625 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_function GO:0008097 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008097 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GeneID 947804 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947804 HAMAP MF_01337_B http://hamap.expasy.org/unirule/MF_01337_B HOGENOM HOG000248742 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000248742&db=HOGENOM6 InParanoid P0C018 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0C018 IntAct P0C018 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0C018* InterPro IPR004389 http://www.ebi.ac.uk/interpro/entry/IPR004389 InterPro IPR005484 http://www.ebi.ac.uk/interpro/entry/IPR005484 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW3266 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3266 KEGG_Gene eco:b3304 http://www.genome.jp/dbget-bin/www_bget?eco:b3304 KEGG_Orthology KO:K02881 http://www.genome.jp/dbget-bin/www_bget?KO:K02881 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 MINT MINT-1293631 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1293631 OMA KRHKRVR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KRHKRVR PDB 1ML5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ML5 PDB 2J28 http://www.ebi.ac.uk/pdbe-srv/view/entry/2J28 PDB 2RDO http://www.ebi.ac.uk/pdbe-srv/view/entry/2RDO PDB 3BBX http://www.ebi.ac.uk/pdbe-srv/view/entry/3BBX PDB 3J5L http://www.ebi.ac.uk/pdbe-srv/view/entry/3J5L PDB 3J7Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J7Z PDB 3J8G http://www.ebi.ac.uk/pdbe-srv/view/entry/3J8G PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 4CSU http://www.ebi.ac.uk/pdbe-srv/view/entry/4CSU PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4UY8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4UY8 PDB 4V47 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V47 PDB 4V48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V48 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5ADY http://www.ebi.ac.uk/pdbe-srv/view/entry/5ADY PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5AKA http://www.ebi.ac.uk/pdbe-srv/view/entry/5AKA PDB 5GAD http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAD PDB 5GAE http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAE PDB 5GAF http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAF PDB 5GAG http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAG PDB 5GAH http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAH PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 1ML5 http://www.ebi.ac.uk/pdbsum/1ML5 PDBsum 2J28 http://www.ebi.ac.uk/pdbsum/2J28 PDBsum 2RDO http://www.ebi.ac.uk/pdbsum/2RDO PDBsum 3BBX http://www.ebi.ac.uk/pdbsum/3BBX PDBsum 3J5L http://www.ebi.ac.uk/pdbsum/3J5L PDBsum 3J7Z http://www.ebi.ac.uk/pdbsum/3J7Z PDBsum 3J8G http://www.ebi.ac.uk/pdbsum/3J8G PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 4CSU http://www.ebi.ac.uk/pdbsum/4CSU PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4UY8 http://www.ebi.ac.uk/pdbsum/4UY8 PDBsum 4V47 http://www.ebi.ac.uk/pdbsum/4V47 PDBsum 4V48 http://www.ebi.ac.uk/pdbsum/4V48 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5ADY http://www.ebi.ac.uk/pdbsum/5ADY PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5AKA http://www.ebi.ac.uk/pdbsum/5AKA PDBsum 5GAD http://www.ebi.ac.uk/pdbsum/5GAD PDBsum 5GAE http://www.ebi.ac.uk/pdbsum/5GAE PDBsum 5GAF http://www.ebi.ac.uk/pdbsum/5GAF PDBsum 5GAG http://www.ebi.ac.uk/pdbsum/5GAG PDBsum 5GAH http://www.ebi.ac.uk/pdbsum/5GAH PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PSORT swissprot:RL18_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RL18_ECOLI PSORT-B swissprot:RL18_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RL18_ECOLI PSORT2 swissprot:RL18_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RL18_ECOLI Pfam PF00861 http://pfam.xfam.org/family/PF00861 Phobius swissprot:RL18_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RL18_ECOLI PhylomeDB P0C018 http://phylomedb.org/?seqid=P0C018 ProteinModelPortal P0C018 http://www.proteinmodelportal.org/query/uniprot/P0C018 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 10529214 http://www.ncbi.nlm.nih.gov/pubmed/10529214 PubMed 109811 http://www.ncbi.nlm.nih.gov/pubmed/109811 PubMed 1098937 http://www.ncbi.nlm.nih.gov/pubmed/1098937 PubMed 12809609 http://www.ncbi.nlm.nih.gov/pubmed/12809609 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 24844575 http://www.ncbi.nlm.nih.gov/pubmed/24844575 PubMed 25310980 http://www.ncbi.nlm.nih.gov/pubmed/25310980 PubMed 353728 http://www.ncbi.nlm.nih.gov/pubmed/353728 PubMed 354687 http://www.ncbi.nlm.nih.gov/pubmed/354687 PubMed 6159586 http://www.ncbi.nlm.nih.gov/pubmed/6159586 PubMed 6222285 http://www.ncbi.nlm.nih.gov/pubmed/6222285 PubMed 7038683 http://www.ncbi.nlm.nih.gov/pubmed/7038683 PubMed 8925931 http://www.ncbi.nlm.nih.gov/pubmed/8925931 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417763 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417763 RefSeq WP_000358960 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000358960 SMR P0C018 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0C018 STRING 511145.b3304 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3304&targetmode=cogs STRING COG0256 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0256&targetmode=cogs TIGRFAMs TIGR00060 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00060 UniProtKB RL18_ECOLI http://www.uniprot.org/uniprot/RL18_ECOLI UniProtKB-AC P0C018 http://www.uniprot.org/uniprot/P0C018 charge swissprot:RL18_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RL18_ECOLI eggNOG COG0256 http://eggnogapi.embl.de/nog_data/html/tree/COG0256 epestfind swissprot:RL18_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RL18_ECOLI garnier swissprot:RL18_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RL18_ECOLI helixturnhelix swissprot:RL18_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RL18_ECOLI hmoment swissprot:RL18_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RL18_ECOLI iep swissprot:RL18_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RL18_ECOLI inforesidue swissprot:RL18_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RL18_ECOLI octanol swissprot:RL18_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RL18_ECOLI pepcoil swissprot:RL18_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RL18_ECOLI pepdigest swissprot:RL18_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RL18_ECOLI pepinfo swissprot:RL18_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RL18_ECOLI pepnet swissprot:RL18_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RL18_ECOLI pepstats swissprot:RL18_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RL18_ECOLI pepwheel swissprot:RL18_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RL18_ECOLI pepwindow swissprot:RL18_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RL18_ECOLI sigcleave swissprot:RL18_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RL18_ECOLI ## Database ID URL or Descriptions # AltName SYGB_ECOLI Glycyl-tRNA synthetase beta subunit # CATALYTIC ACTIVITY SYGB_ECOLI ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly). # EcoGene EG10410 glyS # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0004814 arginine-tRNA ligase activity; IEA:InterPro. # GO_function GO:0004820 glycine-tRNA ligase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006420 arginyl-tRNA aminoacylation; IEA:InterPro. # GO_process GO:0006426 glycyl-tRNA aminoacylation; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0006520 cellular amino acid metabolic process # Gene3D 1.10.730.10 -; 1. # HAMAP MF_00255 Gly_tRNA_synth_beta # INTERACTION SYGB_ECOLI P00960 glyQ; NbExp=3; IntAct=EBI-551400, EBI-551191; # IntAct P00961 11 # InterPro IPR006194 Gly-tRNA-synth_heterodimer # InterPro IPR008909 DALR_anticod-bd # InterPro IPR009080 tRNAsynth_Ia_anticodon-bd # InterPro IPR015944 Gly-tRNA-synth_bsu # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01007 Amino acid related enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # KEGG_Pathway ko00970 Aminoacyl-tRNA biosynthesis # Organism SYGB_ECOLI Escherichia coli (strain K12) # PATRIC 32122592 VBIEscCol129921_3673 # PIR S47780 SYECGB # PRINTS PR01045 TRNASYNTHGB # PROSITE PS50861 AA_TRNA_LIGASE_II_GLYAB # Pfam PF02092 tRNA_synt_2f # Pfam PF05746 DALR_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SYGB_ECOLI Glycine--tRNA ligase beta subunit # RefSeq NP_418016 NC_000913.3 # RefSeq WP_001291772 NZ_LN832404.1 # SIMILARITY Belongs to the class-II aminoacyl-tRNA synthetase family. {ECO 0000305}. # SUBCELLULAR LOCATION SYGB_ECOLI Cytoplasm. # SUBUNIT SYGB_ECOLI Tetramer of two alpha and two beta subunits. # TIGRFAMs TIGR00211 glyS # eggNOG COG0751 LUCA # eggNOG ENOG4105C38 Bacteria BLAST swissprot:SYGB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SYGB_ECOLI BioCyc ECOL316407:JW3530-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3530-MONOMER BioCyc EcoCyc:GLYS-MONOMER http://biocyc.org/getid?id=EcoCyc:GLYS-MONOMER BioCyc MetaCyc:GLYS-MONOMER http://biocyc.org/getid?id=MetaCyc:GLYS-MONOMER COG COG0751 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0751 DIP DIP-6880N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-6880N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.1.1.14 http://www.genome.jp/dbget-bin/www_bget?EC:6.1.1.14 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01622 http://www.ebi.ac.uk/ena/data/view/J01622 EMBL J01623 http://www.ebi.ac.uk/ena/data/view/J01623 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 6.1.1.14 http://enzyme.expasy.org/EC/6.1.1.14 EchoBASE EB0405 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0405 EcoGene EG10410 http://www.ecogene.org/geneInfo.php?eg_id=EG10410 EnsemblBacteria AAC76583 http://www.ensemblgenomes.org/id/AAC76583 EnsemblBacteria AAC76583 http://www.ensemblgenomes.org/id/AAC76583 EnsemblBacteria BAE77735 http://www.ensemblgenomes.org/id/BAE77735 EnsemblBacteria BAE77735 http://www.ensemblgenomes.org/id/BAE77735 EnsemblBacteria BAE77735 http://www.ensemblgenomes.org/id/BAE77735 EnsemblBacteria b3559 http://www.ensemblgenomes.org/id/b3559 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004814 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004814 GO_function GO:0004820 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004820 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006420 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006420 GO_process GO:0006426 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006426 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 Gene3D 1.10.730.10 http://www.cathdb.info/version/latest/superfamily/1.10.730.10 GeneID 948080 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948080 HAMAP MF_00255 http://hamap.expasy.org/unirule/MF_00255 HOGENOM HOG000264302 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000264302&db=HOGENOM6 InParanoid P00961 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00961 IntAct P00961 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00961* IntEnz 6.1.1.14 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.1.1.14 InterPro IPR006194 http://www.ebi.ac.uk/interpro/entry/IPR006194 InterPro IPR008909 http://www.ebi.ac.uk/interpro/entry/IPR008909 InterPro IPR009080 http://www.ebi.ac.uk/interpro/entry/IPR009080 InterPro IPR015944 http://www.ebi.ac.uk/interpro/entry/IPR015944 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW3530 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3530 KEGG_Gene eco:b3559 http://www.genome.jp/dbget-bin/www_bget?eco:b3559 KEGG_Orthology KO:K01879 http://www.genome.jp/dbget-bin/www_bget?KO:K01879 KEGG_Pathway ko00970 http://www.genome.jp/kegg-bin/show_pathway?ko00970 KEGG_Reaction rn:R03654 http://www.genome.jp/dbget-bin/www_bget?rn:R03654 MINT MINT-1276197 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1276197 OMA LPIPKRM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LPIPKRM PRINTS PR01045 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01045 PROSITE PS50861 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50861 PSORT swissprot:SYGB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SYGB_ECOLI PSORT-B swissprot:SYGB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SYGB_ECOLI PSORT2 swissprot:SYGB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SYGB_ECOLI Pfam PF02092 http://pfam.xfam.org/family/PF02092 Pfam PF05746 http://pfam.xfam.org/family/PF05746 Phobius swissprot:SYGB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SYGB_ECOLI PhylomeDB P00961 http://phylomedb.org/?seqid=P00961 ProteinModelPortal P00961 http://www.proteinmodelportal.org/query/uniprot/P00961 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6290471 http://www.ncbi.nlm.nih.gov/pubmed/6290471 PubMed 6309809 http://www.ncbi.nlm.nih.gov/pubmed/6309809 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_418016 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418016 RefSeq WP_001291772 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001291772 SMR P00961 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00961 STRING 511145.b3559 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3559&targetmode=cogs STRING COG0751 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0751&targetmode=cogs TIGRFAMs TIGR00211 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00211 UniProtKB SYGB_ECOLI http://www.uniprot.org/uniprot/SYGB_ECOLI UniProtKB-AC P00961 http://www.uniprot.org/uniprot/P00961 charge swissprot:SYGB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SYGB_ECOLI eggNOG COG0751 http://eggnogapi.embl.de/nog_data/html/tree/COG0751 eggNOG ENOG4105C38 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C38 epestfind swissprot:SYGB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SYGB_ECOLI garnier swissprot:SYGB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SYGB_ECOLI helixturnhelix swissprot:SYGB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SYGB_ECOLI hmoment swissprot:SYGB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SYGB_ECOLI iep swissprot:SYGB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SYGB_ECOLI inforesidue swissprot:SYGB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SYGB_ECOLI octanol swissprot:SYGB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SYGB_ECOLI pepcoil swissprot:SYGB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SYGB_ECOLI pepdigest swissprot:SYGB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SYGB_ECOLI pepinfo swissprot:SYGB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SYGB_ECOLI pepnet swissprot:SYGB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SYGB_ECOLI pepstats swissprot:SYGB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SYGB_ECOLI pepwheel swissprot:SYGB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SYGB_ECOLI pepwindow swissprot:SYGB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SYGB_ECOLI sigcleave swissprot:SYGB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SYGB_ECOLI ## Database ID URL or Descriptions # BioGrid 4261916 492 # CAUTION YHCB_ECOLI Was originally thought to be a member of the cytochrome bd-I complex (PubMed 16079137). Subsequent work suggests this is not the case (PubMed 16863643). {ECO 0000305|PubMed 16079137, ECO 0000305|PubMed 16863643}. # DISRUPTION PHENOTYPE No change in function or assembly of the cytochrome bd-I complex. {ECO:0000269|PubMed 16863643}. # EcoGene EG12614 yhcB # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # InterPro IPR009386 DUF1043 # Organism YHCB_ECOLI Escherichia coli (strain K12) # PATRIC 32121892 VBIEscCol129921_3330 # PIR C65115 C65115 # PIRSF PIRSF006318 YhcB # Pfam PF06295 DUF1043 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHCB_ECOLI Inner membrane protein YhcB # RefSeq NP_417700 NC_000913.3 # RefSeq WP_001295270 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA58035.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY To H.influenzae HI_1628. {ECO 0000305}. # SUBCELLULAR LOCATION YHCB_ECOLI Cell inner membrane {ECO 0000269|PubMed 16079137, ECO 0000269|PubMed 21210718}; Single-pass membrane protein {ECO 0000269|PubMed 16079137, ECO 0000269|PubMed 21210718}. # SUBUNIT Forms homooligomers. {ECO:0000269|PubMed 21210718}. # eggNOG COG3105 LUCA # eggNOG ENOG4108W2Q Bacteria BLAST swissprot:YHCB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHCB_ECOLI BioCyc ECOL316407:JW5539-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5539-MONOMER BioCyc EcoCyc:G7681-MONOMER http://biocyc.org/getid?id=EcoCyc:G7681-MONOMER COG COG3105 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3105 DIP DIP-39900N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-39900N DOI 10.1016/j.bbabio.2006.05.043 http://dx.doi.org/10.1016/j.bbabio.2006.05.043 DOI 10.1021/pr101105c http://dx.doi.org/10.1021/pr101105c DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U15661 http://www.ebi.ac.uk/ena/data/view/U15661 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2498 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2498 EcoGene EG12614 http://www.ecogene.org/geneInfo.php?eg_id=EG12614 EnsemblBacteria AAC76265 http://www.ensemblgenomes.org/id/AAC76265 EnsemblBacteria AAC76265 http://www.ensemblgenomes.org/id/AAC76265 EnsemblBacteria BAE77276 http://www.ensemblgenomes.org/id/BAE77276 EnsemblBacteria BAE77276 http://www.ensemblgenomes.org/id/BAE77276 EnsemblBacteria BAE77276 http://www.ensemblgenomes.org/id/BAE77276 EnsemblBacteria b3233 http://www.ensemblgenomes.org/id/b3233 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GeneID 947815 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947815 HOGENOM HOG000283931 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000283931&db=HOGENOM6 InParanoid P0ADW3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADW3 IntAct P0ADW3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADW3* InterPro IPR009386 http://www.ebi.ac.uk/interpro/entry/IPR009386 KEGG_Gene ecj:JW5539 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5539 KEGG_Gene eco:b3233 http://www.genome.jp/dbget-bin/www_bget?eco:b3233 KEGG_Orthology KO:K09908 http://www.genome.jp/dbget-bin/www_bget?KO:K09908 OMA QPRDYSE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QPRDYSE PSORT swissprot:YHCB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHCB_ECOLI PSORT-B swissprot:YHCB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHCB_ECOLI PSORT2 swissprot:YHCB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHCB_ECOLI Pfam PF06295 http://pfam.xfam.org/family/PF06295 Phobius swissprot:YHCB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHCB_ECOLI ProteinModelPortal P0ADW3 http://www.proteinmodelportal.org/query/uniprot/P0ADW3 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16863643 http://www.ncbi.nlm.nih.gov/pubmed/16863643 PubMed 21210718 http://www.ncbi.nlm.nih.gov/pubmed/21210718 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417700 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417700 RefSeq WP_001295270 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295270 STRING 511145.b3233 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3233&targetmode=cogs STRING COG3105 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3105&targetmode=cogs UniProtKB YHCB_ECOLI http://www.uniprot.org/uniprot/YHCB_ECOLI UniProtKB-AC P0ADW3 http://www.uniprot.org/uniprot/P0ADW3 charge swissprot:YHCB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHCB_ECOLI eggNOG COG3105 http://eggnogapi.embl.de/nog_data/html/tree/COG3105 eggNOG ENOG4108W2Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108W2Q epestfind swissprot:YHCB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHCB_ECOLI garnier swissprot:YHCB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHCB_ECOLI helixturnhelix swissprot:YHCB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHCB_ECOLI hmoment swissprot:YHCB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHCB_ECOLI iep swissprot:YHCB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHCB_ECOLI inforesidue swissprot:YHCB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHCB_ECOLI octanol swissprot:YHCB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHCB_ECOLI pepcoil swissprot:YHCB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHCB_ECOLI pepdigest swissprot:YHCB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHCB_ECOLI pepinfo swissprot:YHCB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHCB_ECOLI pepnet swissprot:YHCB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHCB_ECOLI pepstats swissprot:YHCB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHCB_ECOLI pepwheel swissprot:YHCB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHCB_ECOLI pepwindow swissprot:YHCB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHCB_ECOLI sigcleave swissprot:YHCB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHCB_ECOLI ## Database ID URL or Descriptions # BioGrid 4261276 223 # CATALYTIC ACTIVITY NUDE_ECOLI ADP-ribose + H(2)O = AMP + D-ribose 5- phosphate. # COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI 18420; Note=Mg(2+). Other divalent cations can also be used.; # EcoGene EG12926 nudE # FUNCTION NUDE_ECOLI Active on adenosine(5')triphospho(5')adenosine (Ap3A), ADP-ribose, NADH, adenosine(5')diphospho(5')adenosine (Ap2A). # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0019144 ADP-sugar diphosphatase activity; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # Gene3D 3.90.79.10 -; 1. # InterPro IPR000086 NUDIX_hydrolase_dom # InterPro IPR015797 NUDIX_hydrolase_dom-like # InterPro IPR020084 NUDIX_hydrolase_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # Organism NUDE_ECOLI Escherichia coli (strain K12) # PATRIC 32122226 VBIEscCol129921_3490 # PDB 1VHG X-ray; 2.70 A; A/B=2-186 # PDB 1VHZ X-ray; 2.32 A; A/B=2-186 # PIR H65134 H65134 # PROSITE PS00893 NUDIX_BOX # PROSITE PS51462 NUDIX # Pfam PF00293 NUDIX # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NUDE_ECOLI ADP compounds hydrolase NudE # RefSeq NP_417856 NC_000913.3 # RefSeq WP_000045744 NZ_LN832404.1 # SIMILARITY Belongs to the Nudix hydrolase family. {ECO 0000305}. # SIMILARITY Contains 1 nudix hydrolase domain. {ECO:0000255|PROSITE-ProRule PRU00794}. # SUBUNIT Homodimer. {ECO:0000305|PubMed 16021622}. # SUPFAM SSF55811 SSF55811 # eggNOG COG0494 LUCA # eggNOG ENOG4107RK2 Bacteria BLAST swissprot:NUDE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NUDE_ECOLI BioCyc ECOL316407:JW3360-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3360-MONOMER BioCyc EcoCyc:G7740-MONOMER http://biocyc.org/getid?id=EcoCyc:G7740-MONOMER BioCyc MetaCyc:G7740-MONOMER http://biocyc.org/getid?id=MetaCyc:G7740-MONOMER COG COG0494 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0494 DOI 10.1002/prot.20541 http://dx.doi.org/10.1002/prot.20541 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.273.6.3192 http://dx.doi.org/10.1074/jbc.273.6.3192 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.1.- http://www.genome.jp/dbget-bin/www_bget?EC:3.6.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 3.6.1.- http://enzyme.expasy.org/EC/3.6.1.- EchoBASE EB2762 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2762 EcoGene EG12926 http://www.ecogene.org/geneInfo.php?eg_id=EG12926 EnsemblBacteria AAC76422 http://www.ensemblgenomes.org/id/AAC76422 EnsemblBacteria AAC76422 http://www.ensemblgenomes.org/id/AAC76422 EnsemblBacteria BAE77894 http://www.ensemblgenomes.org/id/BAE77894 EnsemblBacteria BAE77894 http://www.ensemblgenomes.org/id/BAE77894 EnsemblBacteria BAE77894 http://www.ensemblgenomes.org/id/BAE77894 EnsemblBacteria b3397 http://www.ensemblgenomes.org/id/b3397 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0019144 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019144 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.90.79.10 http://www.cathdb.info/version/latest/superfamily/3.90.79.10 GeneID 947906 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947906 HOGENOM HOG000045856 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000045856&db=HOGENOM6 InParanoid P45799 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45799 IntAct P45799 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45799* IntEnz 3.6.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.1 InterPro IPR000086 http://www.ebi.ac.uk/interpro/entry/IPR000086 InterPro IPR015797 http://www.ebi.ac.uk/interpro/entry/IPR015797 InterPro IPR020084 http://www.ebi.ac.uk/interpro/entry/IPR020084 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3360 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3360 KEGG_Gene eco:b3397 http://www.genome.jp/dbget-bin/www_bget?eco:b3397 KEGG_Orthology KO:K08312 http://www.genome.jp/dbget-bin/www_bget?KO:K08312 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Reaction rn:R01054 http://www.genome.jp/dbget-bin/www_bget?rn:R01054 OMA GTHSYEL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GTHSYEL PDB 1VHG http://www.ebi.ac.uk/pdbe-srv/view/entry/1VHG PDB 1VHZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1VHZ PDBsum 1VHG http://www.ebi.ac.uk/pdbsum/1VHG PDBsum 1VHZ http://www.ebi.ac.uk/pdbsum/1VHZ PROSITE PS00893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00893 PROSITE PS51462 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51462 PSORT swissprot:NUDE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NUDE_ECOLI PSORT-B swissprot:NUDE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NUDE_ECOLI PSORT2 swissprot:NUDE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NUDE_ECOLI Pfam PF00293 http://pfam.xfam.org/family/PF00293 Phobius swissprot:NUDE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NUDE_ECOLI PhylomeDB P45799 http://phylomedb.org/?seqid=P45799 ProteinModelPortal P45799 http://www.proteinmodelportal.org/query/uniprot/P45799 PubMed 16021622 http://www.ncbi.nlm.nih.gov/pubmed/16021622 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9452430 http://www.ncbi.nlm.nih.gov/pubmed/9452430 RefSeq NP_417856 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417856 RefSeq WP_000045744 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000045744 SMR P45799 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45799 STRING 511145.b3397 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3397&targetmode=cogs STRING COG0494 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0494&targetmode=cogs SUPFAM SSF55811 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55811 UniProtKB NUDE_ECOLI http://www.uniprot.org/uniprot/NUDE_ECOLI UniProtKB-AC P45799 http://www.uniprot.org/uniprot/P45799 charge swissprot:NUDE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NUDE_ECOLI eggNOG COG0494 http://eggnogapi.embl.de/nog_data/html/tree/COG0494 eggNOG ENOG4107RK2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107RK2 epestfind swissprot:NUDE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NUDE_ECOLI garnier swissprot:NUDE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NUDE_ECOLI helixturnhelix swissprot:NUDE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NUDE_ECOLI hmoment swissprot:NUDE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NUDE_ECOLI iep swissprot:NUDE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NUDE_ECOLI inforesidue swissprot:NUDE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NUDE_ECOLI octanol swissprot:NUDE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NUDE_ECOLI pepcoil swissprot:NUDE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NUDE_ECOLI pepdigest swissprot:NUDE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NUDE_ECOLI pepinfo swissprot:NUDE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NUDE_ECOLI pepnet swissprot:NUDE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NUDE_ECOLI pepstats swissprot:NUDE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NUDE_ECOLI pepwheel swissprot:NUDE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NUDE_ECOLI pepwindow swissprot:NUDE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NUDE_ECOLI sigcleave swissprot:NUDE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NUDE_ECOLI ## Database ID URL or Descriptions # EcoGene EG40008 insH8 # FUNCTION INSH8_ECOLI Involved in the transposition of the insertion sequence IS5. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # InterPro IPR002559 Transposase_11 # InterPro IPR008490 Transposase_InsH_N # Organism INSH8_ECOLI Escherichia coli (strain K12) # Pfam PF01609 DDE_Tnp_1 # Pfam PF05598 DUF772 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSH8_ECOLI Transposase InsH for insertion sequence element IS5K # RefSeq NP_414793 NC_000913.3 # RefSeq NP_415084 NC_000913.3 # RefSeq NP_415189 NC_000913.3 # RefSeq NP_415847 NC_000913.3 # RefSeq NP_416535 NC_000913.3 # RefSeq NP_416696 NC_000913.3 # RefSeq NP_417456 NC_000913.3 # RefSeq NP_417685 NC_000913.3 # RefSeq NP_417962 NC_000913.3 # SIMILARITY Belongs to the transposase 11 family. {ECO 0000305}. # eggNOG COG3039 LUCA # eggNOG ENOG4105F2I Bacteria BLAST swissprot:INSH8_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSH8_ECOLI BioCyc EcoCyc:MONOMER0-4238 http://biocyc.org/getid?id=EcoCyc:MONOMER0-4238 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4736 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4736 EcoGene EG40008 http://www.ecogene.org/geneInfo.php?eg_id=EG40008 EnsemblBacteria AAC75252 http://www.ensemblgenomes.org/id/AAC75252 EnsemblBacteria AAC75252 http://www.ensemblgenomes.org/id/AAC75252 EnsemblBacteria BAE76655 http://www.ensemblgenomes.org/id/BAE76655 EnsemblBacteria BAE76655 http://www.ensemblgenomes.org/id/BAE76655 EnsemblBacteria BAE76655 http://www.ensemblgenomes.org/id/BAE76655 EnsemblBacteria b2192 http://www.ensemblgenomes.org/id/b2192 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GeneID 944917 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944917 GeneID 944941 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944941 GeneID 945896 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945896 GeneID 946163 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946163 GeneID 946577 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946577 GeneID 947516 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947516 GeneID 947743 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947743 GeneID 948015 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948015 GeneID 949121 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949121 InParanoid P0CE55 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CE55 InterPro IPR002559 http://www.ebi.ac.uk/interpro/entry/IPR002559 InterPro IPR008490 http://www.ebi.ac.uk/interpro/entry/IPR008490 KEGG_Gene ecj:JW2179 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2179 KEGG_Gene eco:b0259 http://www.genome.jp/dbget-bin/www_bget?eco:b0259 KEGG_Gene eco:b0552 http://www.genome.jp/dbget-bin/www_bget?eco:b0552 KEGG_Gene eco:b0656 http://www.genome.jp/dbget-bin/www_bget?eco:b0656 KEGG_Gene eco:b1331 http://www.genome.jp/dbget-bin/www_bget?eco:b1331 KEGG_Gene eco:b2030 http://www.genome.jp/dbget-bin/www_bget?eco:b2030 KEGG_Gene eco:b2192 http://www.genome.jp/dbget-bin/www_bget?eco:b2192 KEGG_Gene eco:b2982 http://www.genome.jp/dbget-bin/www_bget?eco:b2982 KEGG_Gene eco:b3218 http://www.genome.jp/dbget-bin/www_bget?eco:b3218 KEGG_Gene eco:b3505 http://www.genome.jp/dbget-bin/www_bget?eco:b3505 PSORT swissprot:INSH8_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSH8_ECOLI PSORT-B swissprot:INSH8_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSH8_ECOLI PSORT2 swissprot:INSH8_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSH8_ECOLI Pfam PF01609 http://pfam.xfam.org/family/PF01609 Pfam PF05598 http://pfam.xfam.org/family/PF05598 Phobius swissprot:INSH8_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSH8_ECOLI PhylomeDB P0CE55 http://phylomedb.org/?seqid=P0CE55 ProteinModelPortal P0CE55 http://www.proteinmodelportal.org/query/uniprot/P0CE55 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414793 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414793 RefSeq NP_415084 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415084 RefSeq NP_415189 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415189 RefSeq NP_415847 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415847 RefSeq NP_416535 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416535 RefSeq NP_416696 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416696 RefSeq NP_417456 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417456 RefSeq NP_417685 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417685 RefSeq NP_417962 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417962 SMR P0CE55 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0CE55 STRING 511145.b3505 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3505&targetmode=cogs UniProtKB INSH8_ECOLI http://www.uniprot.org/uniprot/INSH8_ECOLI UniProtKB-AC P0CE55 http://www.uniprot.org/uniprot/P0CE55 charge swissprot:INSH8_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSH8_ECOLI eggNOG COG3039 http://eggnogapi.embl.de/nog_data/html/tree/COG3039 eggNOG ENOG4105F2I http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F2I epestfind swissprot:INSH8_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSH8_ECOLI garnier swissprot:INSH8_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSH8_ECOLI helixturnhelix swissprot:INSH8_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSH8_ECOLI hmoment swissprot:INSH8_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSH8_ECOLI iep swissprot:INSH8_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSH8_ECOLI inforesidue swissprot:INSH8_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSH8_ECOLI octanol swissprot:INSH8_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSH8_ECOLI pepcoil swissprot:INSH8_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSH8_ECOLI pepdigest swissprot:INSH8_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSH8_ECOLI pepinfo swissprot:INSH8_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSH8_ECOLI pepnet swissprot:INSH8_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSH8_ECOLI pepstats swissprot:INSH8_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSH8_ECOLI pepwheel swissprot:INSH8_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSH8_ECOLI pepwindow swissprot:INSH8_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSH8_ECOLI sigcleave swissprot:INSH8_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSH8_ECOLI ## Database ID URL or Descriptions # BioGrid 4261577 12 # CATALYTIC ACTIVITY HCAE_ECOLI (2E)-3-phenylprop-2-enoate + NADH + O(2) = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + NAD(+). # CATALYTIC ACTIVITY HCAE_ECOLI 3-phenylpropanoate + NADH + O(2) = 3-(cis-5,6- dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+). # COFACTOR HCAE_ECOLI Name=Fe cation; Xref=ChEBI CHEBI 24875; Evidence={ECO 0000305}; Note=Binds 1 Fe cation. {ECO 0000305}; # COFACTOR HCAE_ECOLI Name=[2Fe-2S] cluster; Xref=ChEBI CHEBI 49601; Evidence={ECO 0000305}; Note=Binds 1 [2Fe-2S] cluster. {ECO 0000305}; # EcoGene EG13456 hcaE # FUNCTION HCAE_ECOLI Part of the multicomponent 3-phenylpropionate dioxygenase. Converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol), respectively. {ECO 0000269|PubMed 9603882}. # GO_function GO:0005506 iron ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008695 3-phenylpropionate dioxygenase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0051537 2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0019380 3-phenylpropionate catabolic process; IMP:EcoCyc. # GO_process GO:0019439 aromatic compound catabolic process; IEA:UniProtKB-HAMAP. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 2.102.10.10 -; 1. # Gene3D 3.90.380.10 -; 1. # HAMAP MF_01648 HcaE # IntAct P0ABR5 5 # InterPro IPR001663 Rng_hydr_dOase-A # InterPro IPR015879 Ring_hydroxy_dOase_asu_C_dom # InterPro IPR015881 Ring-hydroxy_dOase_2Fe2S_BS # InterPro IPR017941 Rieske_2Fe-2S # InterPro IPR020875 HcaE # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00360 Phenylalanine metabolism # Organism HCAE_ECOLI Escherichia coli (strain K12) # PATHWAY HCAE_ECOLI Aromatic compound metabolism; 3-phenylpropanoate degradation. # PATRIC 32120473 VBIEscCol129921_2639 # PIR A65031 A65031 # PRINTS PR00090 RNGDIOXGNASE # PROSITE PS00570 RING_HYDROXYL_ALPHA # PROSITE PS51296 RIESKE # Pfam PF00355 Rieske # Pfam PF00848 Ring_hydroxyl_A # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HCAE_ECOLI 3-phenylpropionate/cinnamic acid dioxygenase subunit alpha # RefSeq NP_417033 NC_000913.3 # RefSeq WP_000211172 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial ring-hydroxylating dioxygenase alpha subunit family. {ECO 0000305}. # SIMILARITY Contains 1 Rieske domain. {ECO 0000305}. # SUBUNIT This dioxygenase system consists of four proteins the two subunits of the hydroxylase component (HcaE and HcaF), a ferredoxin (HcaC) and a ferredoxin reductase (HcaD). # SUPFAM SSF50022 SSF50022 # eggNOG COG4638 LUCA # eggNOG ENOG4105FUY Bacteria BLAST swissprot:HCAE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HCAE_ECOLI BioCyc ECOL316407:JW2522-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2522-MONOMER BioCyc EcoCyc:PHENYLPRODIOXY-MONOMER http://biocyc.org/getid?id=EcoCyc:PHENYLPRODIOXY-MONOMER BioCyc MetaCyc:PHENYLPRODIOXY-MONOMER http://biocyc.org/getid?id=MetaCyc:PHENYLPRODIOXY-MONOMER COG COG4638 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4638 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.14.12.19 http://www.genome.jp/dbget-bin/www_bget?EC:1.14.12.19 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL Z37966 http://www.ebi.ac.uk/ena/data/view/Z37966 ENZYME 1.14.12.19 http://enzyme.expasy.org/EC/1.14.12.19 EchoBASE EB3229 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3229 EcoGene EG13456 http://www.ecogene.org/geneInfo.php?eg_id=EG13456 EnsemblBacteria AAC75591 http://www.ensemblgenomes.org/id/AAC75591 EnsemblBacteria AAC75591 http://www.ensemblgenomes.org/id/AAC75591 EnsemblBacteria BAA16441 http://www.ensemblgenomes.org/id/BAA16441 EnsemblBacteria BAA16441 http://www.ensemblgenomes.org/id/BAA16441 EnsemblBacteria BAA16441 http://www.ensemblgenomes.org/id/BAA16441 EnsemblBacteria b2538 http://www.ensemblgenomes.org/id/b2538 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0008695 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008695 GO_function GO:0051537 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051537 GO_process GO:0019380 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019380 GO_process GO:0019439 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019439 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 2.102.10.10 http://www.cathdb.info/version/latest/superfamily/2.102.10.10 Gene3D 3.90.380.10 http://www.cathdb.info/version/latest/superfamily/3.90.380.10 GeneID 946998 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946998 HAMAP MF_01648 http://hamap.expasy.org/unirule/MF_01648 HOGENOM HOG000105925 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000105925&db=HOGENOM6 InParanoid P0ABR5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABR5 IntAct P0ABR5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABR5* IntEnz 1.14.12.19 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.14.12.19 InterPro IPR001663 http://www.ebi.ac.uk/interpro/entry/IPR001663 InterPro IPR015879 http://www.ebi.ac.uk/interpro/entry/IPR015879 InterPro IPR015881 http://www.ebi.ac.uk/interpro/entry/IPR015881 InterPro IPR017941 http://www.ebi.ac.uk/interpro/entry/IPR017941 InterPro IPR020875 http://www.ebi.ac.uk/interpro/entry/IPR020875 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2522 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2522 KEGG_Gene eco:b2538 http://www.genome.jp/dbget-bin/www_bget?eco:b2538 KEGG_Orthology KO:K05708 http://www.genome.jp/dbget-bin/www_bget?KO:K05708 KEGG_Pathway ko00360 http://www.genome.jp/kegg-bin/show_pathway?ko00360 KEGG_Reaction rn:R06782 http://www.genome.jp/dbget-bin/www_bget?rn:R06782 KEGG_Reaction rn:R06783 http://www.genome.jp/dbget-bin/www_bget?rn:R06783 OMA KANGEHK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KANGEHK PRINTS PR00090 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00090 PROSITE PS00570 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00570 PROSITE PS51296 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51296 PSORT swissprot:HCAE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HCAE_ECOLI PSORT-B swissprot:HCAE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HCAE_ECOLI PSORT2 swissprot:HCAE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HCAE_ECOLI Pfam PF00355 http://pfam.xfam.org/family/PF00355 Pfam PF00848 http://pfam.xfam.org/family/PF00848 Phobius swissprot:HCAE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HCAE_ECOLI PhylomeDB P0ABR5 http://phylomedb.org/?seqid=P0ABR5 ProteinModelPortal P0ABR5 http://www.proteinmodelportal.org/query/uniprot/P0ABR5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9603882 http://www.ncbi.nlm.nih.gov/pubmed/9603882 RefSeq NP_417033 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417033 RefSeq WP_000211172 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000211172 SMR P0ABR5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABR5 STRING 511145.b2538 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2538&targetmode=cogs STRING COG4638 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4638&targetmode=cogs SUPFAM SSF50022 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50022 UniProtKB HCAE_ECOLI http://www.uniprot.org/uniprot/HCAE_ECOLI UniProtKB-AC P0ABR5 http://www.uniprot.org/uniprot/P0ABR5 charge swissprot:HCAE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HCAE_ECOLI eggNOG COG4638 http://eggnogapi.embl.de/nog_data/html/tree/COG4638 eggNOG ENOG4105FUY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FUY epestfind swissprot:HCAE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HCAE_ECOLI garnier swissprot:HCAE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HCAE_ECOLI helixturnhelix swissprot:HCAE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HCAE_ECOLI hmoment swissprot:HCAE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HCAE_ECOLI iep swissprot:HCAE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HCAE_ECOLI inforesidue swissprot:HCAE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HCAE_ECOLI octanol swissprot:HCAE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HCAE_ECOLI pepcoil swissprot:HCAE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HCAE_ECOLI pepdigest swissprot:HCAE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HCAE_ECOLI pepinfo swissprot:HCAE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HCAE_ECOLI pepnet swissprot:HCAE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HCAE_ECOLI pepstats swissprot:HCAE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HCAE_ECOLI pepwheel swissprot:HCAE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HCAE_ECOLI pepwindow swissprot:HCAE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HCAE_ECOLI sigcleave swissprot:HCAE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HCAE_ECOLI ## Database ID URL or Descriptions # AltName LFTR_ECOLI L/F-transferase # AltName LFTR_ECOLI Leucyltransferase # AltName LFTR_ECOLI Phenyalanyltransferase # BRENDA 2.3.2 2026 # BioGrid 4259988 22 # CATALYTIC ACTIVITY LFTR_ECOLI L-leucyl-tRNA(Leu) + [protein] = tRNA(Leu) + L-leucyl-[protein]. # CATALYTIC ACTIVITY LFTR_ECOLI L-phenylalanyl-tRNA(Phe) + [protein] = tRNA + L-phenylalanyl-[protein]. # EcoGene EG11112 aat # FUNCTION LFTR_ECOLI Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_function GO:0008914 leucyltransferase activity; IDA:EcoCyc. # GO_function GO:0016755 transferase activity, transferring amino-acyl groups; IDA:EcoliWiki. # GO_process GO:0030163 protein catabolic process; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0009056 catabolic process # HAMAP MF_00688 Leu_Phe_trans # IntAct P0A8P1 10 # InterPro IPR004616 Leu/Phe-tRNA_Trfase # InterPro IPR016181 Acyl_CoA_acyltransferase # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # Organism LFTR_ECOLI Escherichia coli (strain K12) # PATRIC 32116979 VBIEscCol129921_0914 # PDB 2CXA X-ray; 1.60 A; A=1-234 # PDB 2DPS X-ray; 2.40 A; A/B=1-234 # PDB 2DPT X-ray; 2.75 A; A/B=1-234 # PDB 2Z3K X-ray; 2.85 A; A/B=2-234 # PDB 2Z3L X-ray; 2.75 A; A/B=2-234 # PDB 2Z3M X-ray; 2.70 A; A/B=2-234 # PDB 2Z3N X-ray; 2.50 A; A/B=2-234 # PDB 2Z3O X-ray; 2.40 A; A/B=2-234 # PDB 2Z3P X-ray; 2.50 A; A/B=2-234 # PIR A36888 A36888 # Pfam PF03588 Leu_Phe_trans # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LFTR_ECOLI Leucyl/phenylalanyl-tRNA--protein transferase # RefSeq NP_415405 NC_000913.3 # RefSeq WP_001241678 NZ_LN832404.1 # SIMILARITY Belongs to the L/F-transferase family. {ECO 0000305}. # SUBCELLULAR LOCATION LFTR_ECOLI Cytoplasm. # SUBUNIT LFTR_ECOLI Monomer. # SUPFAM SSF55729 SSF55729 # TIGRFAMs TIGR00667 aat # eggNOG COG2360 LUCA # eggNOG ENOG4108R4Z Bacteria BLAST swissprot:LFTR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LFTR_ECOLI BioCyc ECOL316407:JW0868-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0868-MONOMER BioCyc EcoCyc:EG11112-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11112-MONOMER BioCyc MetaCyc:EG11112-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11112-MONOMER COG COG2360 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2360 DIP DIP-48235N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48235N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.270.35.20621 http://dx.doi.org/10.1074/jbc.270.35.20621 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.2.6 http://www.genome.jp/dbget-bin/www_bget?EC:2.3.2.6 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10383 http://www.ebi.ac.uk/ena/data/view/L10383 EMBL M63145 http://www.ebi.ac.uk/ena/data/view/M63145 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.3.2.6 http://enzyme.expasy.org/EC/2.3.2.6 EchoBASE EB1103 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1103 EcoGene EG11112 http://www.ecogene.org/geneInfo.php?eg_id=EG11112 EnsemblBacteria AAC73971 http://www.ensemblgenomes.org/id/AAC73971 EnsemblBacteria AAC73971 http://www.ensemblgenomes.org/id/AAC73971 EnsemblBacteria BAA35605 http://www.ensemblgenomes.org/id/BAA35605 EnsemblBacteria BAA35605 http://www.ensemblgenomes.org/id/BAA35605 EnsemblBacteria BAA35605 http://www.ensemblgenomes.org/id/BAA35605 EnsemblBacteria b0885 http://www.ensemblgenomes.org/id/b0885 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0008914 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008914 GO_function GO:0016755 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016755 GO_process GO:0030163 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030163 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GeneID 945490 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945490 HAMAP MF_00688 http://hamap.expasy.org/unirule/MF_00688 HOGENOM HOG000102325 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000102325&db=HOGENOM6 InParanoid P0A8P1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8P1 IntAct P0A8P1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8P1* IntEnz 2.3.2.6 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.2.6 InterPro IPR004616 http://www.ebi.ac.uk/interpro/entry/IPR004616 InterPro IPR016181 http://www.ebi.ac.uk/interpro/entry/IPR016181 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW0868 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0868 KEGG_Gene eco:b0885 http://www.genome.jp/dbget-bin/www_bget?eco:b0885 KEGG_Orthology KO:K00684 http://www.genome.jp/dbget-bin/www_bget?KO:K00684 OMA YRQGIFP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YRQGIFP PDB 2CXA http://www.ebi.ac.uk/pdbe-srv/view/entry/2CXA PDB 2DPS http://www.ebi.ac.uk/pdbe-srv/view/entry/2DPS PDB 2DPT http://www.ebi.ac.uk/pdbe-srv/view/entry/2DPT PDB 2Z3K http://www.ebi.ac.uk/pdbe-srv/view/entry/2Z3K PDB 2Z3L http://www.ebi.ac.uk/pdbe-srv/view/entry/2Z3L PDB 2Z3M http://www.ebi.ac.uk/pdbe-srv/view/entry/2Z3M PDB 2Z3N http://www.ebi.ac.uk/pdbe-srv/view/entry/2Z3N PDB 2Z3O http://www.ebi.ac.uk/pdbe-srv/view/entry/2Z3O PDB 2Z3P http://www.ebi.ac.uk/pdbe-srv/view/entry/2Z3P PDBsum 2CXA http://www.ebi.ac.uk/pdbsum/2CXA PDBsum 2DPS http://www.ebi.ac.uk/pdbsum/2DPS PDBsum 2DPT http://www.ebi.ac.uk/pdbsum/2DPT PDBsum 2Z3K http://www.ebi.ac.uk/pdbsum/2Z3K PDBsum 2Z3L http://www.ebi.ac.uk/pdbsum/2Z3L PDBsum 2Z3M http://www.ebi.ac.uk/pdbsum/2Z3M PDBsum 2Z3N http://www.ebi.ac.uk/pdbsum/2Z3N PDBsum 2Z3O http://www.ebi.ac.uk/pdbsum/2Z3O PDBsum 2Z3P http://www.ebi.ac.uk/pdbsum/2Z3P PSORT swissprot:LFTR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LFTR_ECOLI PSORT-B swissprot:LFTR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LFTR_ECOLI PSORT2 swissprot:LFTR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LFTR_ECOLI Pfam PF03588 http://pfam.xfam.org/family/PF03588 Phobius swissprot:LFTR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LFTR_ECOLI PhylomeDB P0A8P1 http://phylomedb.org/?seqid=P0A8P1 ProteinModelPortal P0A8P1 http://www.proteinmodelportal.org/query/uniprot/P0A8P1 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1909328 http://www.ncbi.nlm.nih.gov/pubmed/1909328 PubMed 7657641 http://www.ncbi.nlm.nih.gov/pubmed/7657641 PubMed 8331068 http://www.ncbi.nlm.nih.gov/pubmed/8331068 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415405 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415405 RefSeq WP_001241678 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001241678 SMR P0A8P1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8P1 STRING 511145.b0885 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0885&targetmode=cogs STRING COG2360 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2360&targetmode=cogs SUPFAM SSF55729 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55729 TIGRFAMs TIGR00667 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00667 UniProtKB LFTR_ECOLI http://www.uniprot.org/uniprot/LFTR_ECOLI UniProtKB-AC P0A8P1 http://www.uniprot.org/uniprot/P0A8P1 charge swissprot:LFTR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LFTR_ECOLI eggNOG COG2360 http://eggnogapi.embl.de/nog_data/html/tree/COG2360 eggNOG ENOG4108R4Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108R4Z epestfind swissprot:LFTR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LFTR_ECOLI garnier swissprot:LFTR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LFTR_ECOLI helixturnhelix swissprot:LFTR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LFTR_ECOLI hmoment swissprot:LFTR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LFTR_ECOLI iep swissprot:LFTR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LFTR_ECOLI inforesidue swissprot:LFTR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LFTR_ECOLI octanol swissprot:LFTR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LFTR_ECOLI pepcoil swissprot:LFTR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LFTR_ECOLI pepdigest swissprot:LFTR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LFTR_ECOLI pepinfo swissprot:LFTR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LFTR_ECOLI pepnet swissprot:LFTR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LFTR_ECOLI pepstats swissprot:LFTR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LFTR_ECOLI pepwheel swissprot:LFTR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LFTR_ECOLI pepwindow swissprot:LFTR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LFTR_ECOLI sigcleave swissprot:LFTR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LFTR_ECOLI ## Database ID URL or Descriptions # BioGrid 4263052 7 # EcoGene EG11209 psiE # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0016036 cellular response to phosphate starvation; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006950 response to stress # HAMAP MF_01048 PsiE # INDUCTION Positively regulated by PhoB and negatively regulated by the cyclic AMP-cAMP receptor protein (cAMP-CRP) complex. {ECO:0000269|PubMed 10986267}. # InterPro IPR009315 P_starv_induced_PsiE # InterPro IPR020948 P_starv_induced_PsiE-like # Organism PSIE_ECOLI Escherichia coli (strain K12) # PATRIC 32123593 VBIEscCol129921_4145 # PIR E65210 E65210 # PIRSF PIRSF029598 PsiE # Pfam PF06146 PsiE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PSIE_ECOLI Protein PsiE # RefSeq NP_418454 NC_000913.3 # RefSeq WP_000202902 NZ_LN832404.1 # SIMILARITY Belongs to the PsiE family. {ECO 0000305}. # SUBCELLULAR LOCATION PSIE_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG COG3223 LUCA # eggNOG ENOG4108VY7 Bacteria BLAST swissprot:PSIE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PSIE_ECOLI BioCyc ECOL316407:JW3990-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3990-MONOMER BioCyc EcoCyc:EG11209-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11209-MONOMER COG COG3223 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3223 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.19.5596-5599.2000 http://dx.doi.org/10.1128/JB.182.19.5596-5599.2000 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J02812 http://www.ebi.ac.uk/ena/data/view/J02812 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1194 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1194 EcoGene EG11209 http://www.ecogene.org/geneInfo.php?eg_id=EG11209 EnsemblBacteria AAC77000 http://www.ensemblgenomes.org/id/AAC77000 EnsemblBacteria AAC77000 http://www.ensemblgenomes.org/id/AAC77000 EnsemblBacteria BAE78032 http://www.ensemblgenomes.org/id/BAE78032 EnsemblBacteria BAE78032 http://www.ensemblgenomes.org/id/BAE78032 EnsemblBacteria BAE78032 http://www.ensemblgenomes.org/id/BAE78032 EnsemblBacteria b4030 http://www.ensemblgenomes.org/id/b4030 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0016036 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016036 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 948528 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948528 HAMAP MF_01048 http://hamap.expasy.org/unirule/MF_01048 HOGENOM HOG000235923 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000235923&db=HOGENOM6 InParanoid P0A7C8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7C8 InterPro IPR009315 http://www.ebi.ac.uk/interpro/entry/IPR009315 InterPro IPR020948 http://www.ebi.ac.uk/interpro/entry/IPR020948 KEGG_Gene ecj:JW3990 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3990 KEGG_Gene eco:b4030 http://www.genome.jp/dbget-bin/www_bget?eco:b4030 KEGG_Orthology KO:K13256 http://www.genome.jp/dbget-bin/www_bget?KO:K13256 OMA HEWHQKV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HEWHQKV PSORT swissprot:PSIE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PSIE_ECOLI PSORT-B swissprot:PSIE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PSIE_ECOLI PSORT2 swissprot:PSIE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PSIE_ECOLI Pfam PF06146 http://pfam.xfam.org/family/PF06146 Phobius swissprot:PSIE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PSIE_ECOLI ProteinModelPortal P0A7C8 http://www.proteinmodelportal.org/query/uniprot/P0A7C8 PubMed 10986267 http://www.ncbi.nlm.nih.gov/pubmed/10986267 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2820984 http://www.ncbi.nlm.nih.gov/pubmed/2820984 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418454 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418454 RefSeq WP_000202902 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000202902 STRING 511145.b4030 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4030&targetmode=cogs STRING COG3223 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3223&targetmode=cogs UniProtKB PSIE_ECOLI http://www.uniprot.org/uniprot/PSIE_ECOLI UniProtKB-AC P0A7C8 http://www.uniprot.org/uniprot/P0A7C8 charge swissprot:PSIE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PSIE_ECOLI eggNOG COG3223 http://eggnogapi.embl.de/nog_data/html/tree/COG3223 eggNOG ENOG4108VY7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108VY7 epestfind swissprot:PSIE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PSIE_ECOLI garnier swissprot:PSIE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PSIE_ECOLI helixturnhelix swissprot:PSIE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PSIE_ECOLI hmoment swissprot:PSIE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PSIE_ECOLI iep swissprot:PSIE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PSIE_ECOLI inforesidue swissprot:PSIE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PSIE_ECOLI octanol swissprot:PSIE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PSIE_ECOLI pepcoil swissprot:PSIE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PSIE_ECOLI pepdigest swissprot:PSIE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PSIE_ECOLI pepinfo swissprot:PSIE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PSIE_ECOLI pepnet swissprot:PSIE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PSIE_ECOLI pepstats swissprot:PSIE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PSIE_ECOLI pepwheel swissprot:PSIE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PSIE_ECOLI pepwindow swissprot:PSIE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PSIE_ECOLI sigcleave swissprot:PSIE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PSIE_ECOLI ## Database ID URL or Descriptions # BioGrid 4259855 7 # EcoGene EG11657 ybbA # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016887 ATPase activity; IEA:InterPro. # GO_process GO:0006810 transport; IEA:UniProtKB-KW. # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # Gene3D 3.40.50.300 -; 1. # IntAct P0A9T8 2 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00258 Putative ABC transport system # KEGG_Brite ko02000 Transporters # Organism YBBA_ECOLI Escherichia coli (strain K12) # PATRIC 32116149 VBIEscCol129921_0516 # PIR F64780 F64780 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # Pfam PF00005 ABC_tran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBBA_ECOLI Uncharacterized ABC transporter ATP-binding protein YbbA # RefSeq NP_415028 NC_000913.3 # RefSeq WP_001110573 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA # SUPFAM SSF52540 SSF52540 # TCDB 3.A.1.122.15 the atp-binding cassette (abc) superfamily # eggNOG COG4181 LUCA # eggNOG ENOG4108I0Y Bacteria BLAST swissprot:YBBA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBBA_ECOLI BioCyc ECOL316407:JW0484-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0484-MONOMER BioCyc EcoCyc:YBBA-MONOMER http://biocyc.org/getid?id=EcoCyc:YBBA-MONOMER COG COG1136 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1136 COG COG4181 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4181 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L06182 http://www.ebi.ac.uk/ena/data/view/L06182 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EchoBASE EB1609 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1609 EcoGene EG11657 http://www.ecogene.org/geneInfo.php?eg_id=EG11657 EnsemblBacteria AAC73597 http://www.ensemblgenomes.org/id/AAC73597 EnsemblBacteria AAC73597 http://www.ensemblgenomes.org/id/AAC73597 EnsemblBacteria BAE76274 http://www.ensemblgenomes.org/id/BAE76274 EnsemblBacteria BAE76274 http://www.ensemblgenomes.org/id/BAE76274 EnsemblBacteria BAE76274 http://www.ensemblgenomes.org/id/BAE76274 EnsemblBacteria b0495 http://www.ensemblgenomes.org/id/b0495 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945122 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945122 InParanoid P0A9T8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9T8 IntAct P0A9T8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9T8* InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0484 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0484 KEGG_Gene eco:b0495 http://www.genome.jp/dbget-bin/www_bget?eco:b0495 KEGG_Orthology KO:K02003 http://www.genome.jp/dbget-bin/www_bget?KO:K02003 MINT MINT-1283721 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1283721 OMA GGEVNIL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GGEVNIL PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:YBBA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBBA_ECOLI PSORT-B swissprot:YBBA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBBA_ECOLI PSORT2 swissprot:YBBA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBBA_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Phobius swissprot:YBBA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBBA_ECOLI PhylomeDB P0A9T8 http://phylomedb.org/?seqid=P0A9T8 ProteinModelPortal P0A9T8 http://www.proteinmodelportal.org/query/uniprot/P0A9T8 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8098033 http://www.ncbi.nlm.nih.gov/pubmed/8098033 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415028 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415028 RefSeq WP_001110573 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001110573 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P0A9T8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9T8 STRING 511145.b0495 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0495&targetmode=cogs STRING COG1136 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1136&targetmode=cogs STRING COG4181 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4181&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.122.15 http://www.tcdb.org/search/result.php?tc=3.A.1.122.15 UniProtKB YBBA_ECOLI http://www.uniprot.org/uniprot/YBBA_ECOLI UniProtKB-AC P0A9T8 http://www.uniprot.org/uniprot/P0A9T8 charge swissprot:YBBA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBBA_ECOLI eggNOG COG4181 http://eggnogapi.embl.de/nog_data/html/tree/COG4181 eggNOG ENOG4108I0Y http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108I0Y epestfind swissprot:YBBA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBBA_ECOLI garnier swissprot:YBBA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBBA_ECOLI helixturnhelix swissprot:YBBA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBBA_ECOLI hmoment swissprot:YBBA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBBA_ECOLI iep swissprot:YBBA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBBA_ECOLI inforesidue swissprot:YBBA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBBA_ECOLI octanol swissprot:YBBA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBBA_ECOLI pepcoil swissprot:YBBA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBBA_ECOLI pepdigest swissprot:YBBA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBBA_ECOLI pepinfo swissprot:YBBA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBBA_ECOLI pepnet swissprot:YBBA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBBA_ECOLI pepstats swissprot:YBBA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBBA_ECOLI pepwheel swissprot:YBBA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBBA_ECOLI pepwindow swissprot:YBBA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBBA_ECOLI sigcleave swissprot:YBBA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBBA_ECOLI ## Database ID URL or Descriptions # FUNCTION TRAX1_ECOLI Responsible for the N-terminal acetylation of F pilin. {ECO 0000269|PubMed 8444800}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR008875 TraX # InterPro IPR014125 TraX_Ftype # Organism TRAX1_ECOLI Escherichia coli (strain K12) # PIR JQ1338 JQ1338 # Pfam PF05857 TraX # RecName TRAX1_ECOLI Protein TraX # RefSeq NP_061484 NC_002483.1 # RefSeq WP_000205776 NZ_CP014273.1 # SIMILARITY Belongs to the TraX family. {ECO 0000305}. # SUBCELLULAR LOCATION TRAX1_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # TIGRFAMs TIGR02755 TraX_Ftype BLAST swissprot:TRAX1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRAX1_ECOLI DOI 10.1016/0022-2836(90)90145-C http://dx.doi.org/10.1016/0022-2836(90)90145-C DOI 10.1016/0378-1119(91)90469-R http://dx.doi.org/10.1016/0378-1119(91)90469-R EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL M38047 http://www.ebi.ac.uk/ena/data/view/M38047 EMBL U01159 http://www.ebi.ac.uk/ena/data/view/U01159 EMBL X57429 http://www.ebi.ac.uk/ena/data/view/X57429 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 1263541 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263541 InterPro IPR008875 http://www.ebi.ac.uk/interpro/entry/IPR008875 InterPro IPR014125 http://www.ebi.ac.uk/interpro/entry/IPR014125 OMA ILMMALW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ILMMALW PSORT swissprot:TRAX1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRAX1_ECOLI PSORT-B swissprot:TRAX1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRAX1_ECOLI PSORT2 swissprot:TRAX1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRAX1_ECOLI Pfam PF05857 http://pfam.xfam.org/family/PF05857 Phobius swissprot:TRAX1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRAX1_ECOLI ProteinModelPortal P22709 http://www.proteinmodelportal.org/query/uniprot/P22709 PubMed 1916281 http://www.ncbi.nlm.nih.gov/pubmed/1916281 PubMed 2164585 http://www.ncbi.nlm.nih.gov/pubmed/2164585 PubMed 7915817 http://www.ncbi.nlm.nih.gov/pubmed/7915817 PubMed 8444800 http://www.ncbi.nlm.nih.gov/pubmed/8444800 RefSeq NP_061484 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061484 RefSeq WP_000205776 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000205776 TIGRFAMs TIGR02755 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02755 UniProtKB TRAX1_ECOLI http://www.uniprot.org/uniprot/TRAX1_ECOLI UniProtKB-AC P22709 http://www.uniprot.org/uniprot/P22709 charge swissprot:TRAX1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRAX1_ECOLI epestfind swissprot:TRAX1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRAX1_ECOLI garnier swissprot:TRAX1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRAX1_ECOLI helixturnhelix swissprot:TRAX1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRAX1_ECOLI hmoment swissprot:TRAX1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRAX1_ECOLI iep swissprot:TRAX1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRAX1_ECOLI inforesidue swissprot:TRAX1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRAX1_ECOLI octanol swissprot:TRAX1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRAX1_ECOLI pepcoil swissprot:TRAX1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRAX1_ECOLI pepdigest swissprot:TRAX1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRAX1_ECOLI pepinfo swissprot:TRAX1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRAX1_ECOLI pepnet swissprot:TRAX1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRAX1_ECOLI pepstats swissprot:TRAX1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRAX1_ECOLI pepwheel swissprot:TRAX1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRAX1_ECOLI pepwindow swissprot:TRAX1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRAX1_ECOLI sigcleave swissprot:TRAX1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRAX1_ECOLI ## Database ID URL or Descriptions # BioGrid 4262538 178 # EcoGene EG12273 yiaF # IntAct P0ADK0 3 # InterPro IPR021413 DUF3053 # Organism YIAF_ECOLI Escherichia coli (strain K12) # PATRIC 32122580 VBIEscCol129921_3667 # PIR S47775 S47775 # Pfam PF11254 DUF3053 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIAF_ECOLI Uncharacterized protein YiaF # RefSeq NP_418010 NC_000913.3 # RefSeq WP_000190516 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18531.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # eggNOG ENOG4106JH6 Bacteria # eggNOG ENOG410YECY LUCA BLAST swissprot:YIAF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIAF_ECOLI BioCyc ECOL316407:JW5655-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5655-MONOMER BioCyc EcoCyc:EG12273-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12273-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2182 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2182 EcoGene EG12273 http://www.ecogene.org/geneInfo.php?eg_id=EG12273 EnsemblBacteria AAC76578 http://www.ensemblgenomes.org/id/AAC76578 EnsemblBacteria AAC76578 http://www.ensemblgenomes.org/id/AAC76578 EnsemblBacteria BAE77741 http://www.ensemblgenomes.org/id/BAE77741 EnsemblBacteria BAE77741 http://www.ensemblgenomes.org/id/BAE77741 EnsemblBacteria BAE77741 http://www.ensemblgenomes.org/id/BAE77741 EnsemblBacteria b3554 http://www.ensemblgenomes.org/id/b3554 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 948072 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948072 HOGENOM HOG000126013 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126013&db=HOGENOM6 IntAct P0ADK0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADK0* InterPro IPR021413 http://www.ebi.ac.uk/interpro/entry/IPR021413 KEGG_Gene ecj:JW5655 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5655 KEGG_Gene eco:b3554 http://www.genome.jp/dbget-bin/www_bget?eco:b3554 OMA QQATQYN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QQATQYN PSORT swissprot:YIAF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIAF_ECOLI PSORT-B swissprot:YIAF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIAF_ECOLI PSORT2 swissprot:YIAF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIAF_ECOLI Pfam PF11254 http://pfam.xfam.org/family/PF11254 Phobius swissprot:YIAF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIAF_ECOLI ProteinModelPortal P0ADK0 http://www.proteinmodelportal.org/query/uniprot/P0ADK0 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418010 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418010 RefSeq WP_000190516 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000190516 STRING 511145.b3554 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3554&targetmode=cogs UniProtKB YIAF_ECOLI http://www.uniprot.org/uniprot/YIAF_ECOLI UniProtKB-AC P0ADK0 http://www.uniprot.org/uniprot/P0ADK0 charge swissprot:YIAF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIAF_ECOLI eggNOG ENOG4106JH6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106JH6 eggNOG ENOG410YECY http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YECY epestfind swissprot:YIAF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIAF_ECOLI garnier swissprot:YIAF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIAF_ECOLI helixturnhelix swissprot:YIAF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIAF_ECOLI hmoment swissprot:YIAF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIAF_ECOLI iep swissprot:YIAF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIAF_ECOLI inforesidue swissprot:YIAF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIAF_ECOLI octanol swissprot:YIAF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIAF_ECOLI pepcoil swissprot:YIAF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIAF_ECOLI pepdigest swissprot:YIAF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIAF_ECOLI pepinfo swissprot:YIAF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIAF_ECOLI pepnet swissprot:YIAF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIAF_ECOLI pepstats swissprot:YIAF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIAF_ECOLI pepwheel swissprot:YIAF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIAF_ECOLI pepwindow swissprot:YIAF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIAF_ECOLI sigcleave swissprot:YIAF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIAF_ECOLI ## Database ID URL or Descriptions # AltName TFAQ_ECOLI Tail fiber assembly protein homolog from lambdoid prophage Qin # BioGrid 4260218 88 # EcoGene EG13825 tfaQ # InterPro IPR003458 Phage_T4_Gp38_tail_assem # Organism TFAQ_ECOLI Escherichia coli (strain K12) # PATRIC 32118392 VBIEscCol129921_1616 # PIR E64909 E64909 # Pfam PF02413 Caudo_TAP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Prophage tail fiber assembly protein homolog TfaQ {ECO 0000305} # RefSeq NP_416064 NC_000913.3 # RefSeq WP_000885611 NZ_LN832404.1 # SIMILARITY Belongs to the tfa family. {ECO 0000305}. # eggNOG ENOG4105UZW Bacteria # eggNOG ENOG4111ZCI LUCA BLAST swissprot:TFAQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TFAQ_ECOLI BioCyc ECOL316407:JW1539-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1539-MONOMER BioCyc EcoCyc:G6820-MONOMER http://biocyc.org/getid?id=EcoCyc:G6820-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3586 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3586 EcoGene EG13825 http://www.ecogene.org/geneInfo.php?eg_id=EG13825 EnsemblBacteria AAC74619 http://www.ensemblgenomes.org/id/AAC74619 EnsemblBacteria AAC74619 http://www.ensemblgenomes.org/id/AAC74619 EnsemblBacteria BAA15250 http://www.ensemblgenomes.org/id/BAA15250 EnsemblBacteria BAA15250 http://www.ensemblgenomes.org/id/BAA15250 EnsemblBacteria BAA15250 http://www.ensemblgenomes.org/id/BAA15250 EnsemblBacteria b1546 http://www.ensemblgenomes.org/id/b1546 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946060 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946060 HOGENOM HOG000118670 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118670&db=HOGENOM6 InParanoid P76155 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76155 InterPro IPR003458 http://www.ebi.ac.uk/interpro/entry/IPR003458 KEGG_Gene ecj:JW1539 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1539 KEGG_Gene eco:b1546 http://www.genome.jp/dbget-bin/www_bget?eco:b1546 OMA IFDIDEN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IFDIDEN PSORT swissprot:TFAQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TFAQ_ECOLI PSORT-B swissprot:TFAQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TFAQ_ECOLI PSORT2 swissprot:TFAQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TFAQ_ECOLI Pfam PF02413 http://pfam.xfam.org/family/PF02413 Phobius swissprot:TFAQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TFAQ_ECOLI PhylomeDB P76155 http://phylomedb.org/?seqid=P76155 ProteinModelPortal P76155 http://www.proteinmodelportal.org/query/uniprot/P76155 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416064 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416064 RefSeq WP_000885611 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000885611 STRING 511145.b1546 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1546&targetmode=cogs UniProtKB TFAQ_ECOLI http://www.uniprot.org/uniprot/TFAQ_ECOLI UniProtKB-AC P76155 http://www.uniprot.org/uniprot/P76155 charge swissprot:TFAQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TFAQ_ECOLI eggNOG ENOG4105UZW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105UZW eggNOG ENOG4111ZCI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111ZCI epestfind swissprot:TFAQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TFAQ_ECOLI garnier swissprot:TFAQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TFAQ_ECOLI helixturnhelix swissprot:TFAQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TFAQ_ECOLI hmoment swissprot:TFAQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TFAQ_ECOLI iep swissprot:TFAQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TFAQ_ECOLI inforesidue swissprot:TFAQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TFAQ_ECOLI octanol swissprot:TFAQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TFAQ_ECOLI pepcoil swissprot:TFAQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TFAQ_ECOLI pepdigest swissprot:TFAQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TFAQ_ECOLI pepinfo swissprot:TFAQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TFAQ_ECOLI pepnet swissprot:TFAQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TFAQ_ECOLI pepstats swissprot:TFAQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TFAQ_ECOLI pepwheel swissprot:TFAQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TFAQ_ECOLI pepwindow swissprot:TFAQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TFAQ_ECOLI sigcleave swissprot:TFAQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TFAQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4263093 9 # CDD cd07377 WHTH_GntR # EcoGene EG10715 phnF # FUNCTION PHNF_ECOLI Belongs to an operon involved in alkylphosphonate uptake and C-P lyase. Exact function not known. By similarity could be a transcriptional regulator. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0015716 organic phosphonate transport; IEA:UniProtKB-KW. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006810 transport # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # Gene3D 3.40.1410.10 -; 1. # IntAct P16684 2 # InterPro IPR000524 Tscrpt_reg_HTH_GntR # InterPro IPR011663 UTRA # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR012702 CP_lyase_PhnF # InterPro IPR028978 Chorismate_lyase_/UTRA_dom # KEGG_Brite ko03000 Transcription factors # MISCELLANEOUS PHNF_ECOLI The sequence shown is that of strains K12 and B. # Organism PHNF_ECOLI Escherichia coli (strain K12) # PATRIC 32123763 VBIEscCol129921_4230 # PDB 2FA1 X-ray; 1.70 A; A/B=85-241 # PIR G35718 G35718 # PRINTS PR00035 HTHGNTR # PROSITE PS50949 HTH_GNTR # Pfam PF00392 GntR # Pfam PF07702 UTRA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PHNF_ECOLI Probable transcriptional regulator PhnF # RefSeq NP_418526 NC_000913.3 # RefSeq WP_001295387 NZ_LN832404.1 # SIMILARITY Contains 1 HTH gntR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00307}. # SMART SM00345 HTH_GNTR # SMART SM00866 UTRA # SUPFAM SSF46785 SSF46785 # SUPFAM SSF64288 SSF64288 # TIGRFAMs TIGR02325 C_P_lyase_phnF # eggNOG COG2188 LUCA # eggNOG ENOG4107RJJ Bacteria BLAST swissprot:PHNF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PHNF_ECOLI BioCyc ECOL316407:JW4063-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4063-MONOMER BioCyc EcoCyc:EG10715-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10715-MONOMER COG COG2188 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2188 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D90227 http://www.ebi.ac.uk/ena/data/view/D90227 EMBL J05260 http://www.ebi.ac.uk/ena/data/view/J05260 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB0709 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0709 EcoGene EG10715 http://www.ecogene.org/geneInfo.php?eg_id=EG10715 EnsemblBacteria AAC77063 http://www.ensemblgenomes.org/id/AAC77063 EnsemblBacteria AAC77063 http://www.ensemblgenomes.org/id/AAC77063 EnsemblBacteria BAE78105 http://www.ensemblgenomes.org/id/BAE78105 EnsemblBacteria BAE78105 http://www.ensemblgenomes.org/id/BAE78105 EnsemblBacteria BAE78105 http://www.ensemblgenomes.org/id/BAE78105 EnsemblBacteria b4102 http://www.ensemblgenomes.org/id/b4102 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0015716 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015716 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 3.40.1410.10 http://www.cathdb.info/version/latest/superfamily/3.40.1410.10 GeneID 948617 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948617 HOGENOM HOG000228717 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000228717&db=HOGENOM6 InParanoid P16684 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P16684 IntAct P16684 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P16684* InterPro IPR000524 http://www.ebi.ac.uk/interpro/entry/IPR000524 InterPro IPR011663 http://www.ebi.ac.uk/interpro/entry/IPR011663 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR012702 http://www.ebi.ac.uk/interpro/entry/IPR012702 InterPro IPR028978 http://www.ebi.ac.uk/interpro/entry/IPR028978 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW4063 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4063 KEGG_Gene eco:b4102 http://www.genome.jp/dbget-bin/www_bget?eco:b4102 KEGG_Orthology KO:K02043 http://www.genome.jp/dbget-bin/www_bget?KO:K02043 OMA SENEMAD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SENEMAD PDB 2FA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/2FA1 PDBsum 2FA1 http://www.ebi.ac.uk/pdbsum/2FA1 PRINTS PR00035 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00035 PROSITE PS50949 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50949 PSORT swissprot:PHNF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PHNF_ECOLI PSORT-B swissprot:PHNF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PHNF_ECOLI PSORT2 swissprot:PHNF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PHNF_ECOLI Pfam PF00392 http://pfam.xfam.org/family/PF00392 Pfam PF07702 http://pfam.xfam.org/family/PF07702 Phobius swissprot:PHNF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PHNF_ECOLI PhylomeDB P16684 http://phylomedb.org/?seqid=P16684 ProteinModelPortal P16684 http://www.proteinmodelportal.org/query/uniprot/P16684 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1840580 http://www.ncbi.nlm.nih.gov/pubmed/1840580 PubMed 2155230 http://www.ncbi.nlm.nih.gov/pubmed/2155230 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418526 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418526 RefSeq WP_001295387 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295387 SMART SM00345 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00345 SMART SM00866 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00866 SMR P16684 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P16684 STRING 511145.b4102 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4102&targetmode=cogs STRING COG2188 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2188&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SUPFAM SSF64288 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF64288 TIGRFAMs TIGR02325 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02325 UniProtKB PHNF_ECOLI http://www.uniprot.org/uniprot/PHNF_ECOLI UniProtKB-AC P16684 http://www.uniprot.org/uniprot/P16684 charge swissprot:PHNF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PHNF_ECOLI eggNOG COG2188 http://eggnogapi.embl.de/nog_data/html/tree/COG2188 eggNOG ENOG4107RJJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107RJJ epestfind swissprot:PHNF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PHNF_ECOLI garnier swissprot:PHNF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PHNF_ECOLI helixturnhelix swissprot:PHNF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PHNF_ECOLI hmoment swissprot:PHNF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PHNF_ECOLI iep swissprot:PHNF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PHNF_ECOLI inforesidue swissprot:PHNF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PHNF_ECOLI octanol swissprot:PHNF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PHNF_ECOLI pepcoil swissprot:PHNF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PHNF_ECOLI pepdigest swissprot:PHNF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PHNF_ECOLI pepinfo swissprot:PHNF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PHNF_ECOLI pepnet swissprot:PHNF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PHNF_ECOLI pepstats swissprot:PHNF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PHNF_ECOLI pepwheel swissprot:PHNF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PHNF_ECOLI pepwindow swissprot:PHNF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PHNF_ECOLI sigcleave swissprot:PHNF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PHNF_ECOLI ## Database ID URL or Descriptions # AltName IDH_ECOLI IDP # AltName IDH_ECOLI NADP(+)-specific ICDH # AltName IDH_ECOLI Oxalosuccinate decarboxylase # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=11.4 uM for isocitrate {ECO 0000269|PubMed:7761851}; # BRENDA 1.1.1.42 2026 # CATALYTIC ACTIVITY Isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH. {ECO:0000269|PubMed 21151122}. # COFACTOR IDH_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.; # ENZYME REGULATION IDH_ECOLI Inhibition of this enzyme by phosphorylation regulates the branch point between the Krebs cycle and the glyoxylate bypass, which is an alternate route that accumulates carbon for biosynthesis when acetate is the sole carbon source for growth. # EcoGene EG10009 icdC # EcoGene EG10489 icd # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IEA:InterPro. # GO_function GO:0004450 isocitrate dehydrogenase (NADP+) activity; IDA:UniProtKB. # GO_function GO:0051287 NAD binding; IEA:InterPro. # GO_process GO:0006097 glyoxylate cycle; IEA:UniProtKB-KW. # GO_process GO:0006099 tricarboxylic acid cycle; IEA:UniProtKB-KW. # GO_process GO:0006979 response to oxidative stress; IMP:EcoCyc. # GO_process GO:0022900 electron transport chain; IMP:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0006950 response to stress # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.718.10 -; 1. # IntAct P08200 6 # InterPro IPR001804 Isocitrate/isopropylmalate_DH # InterPro IPR004439 Isocitrate_DH_NADP_dimer_prok # InterPro IPR019818 IsoCit/isopropylmalate_DH_CS # InterPro IPR024084 IsoPropMal-DH-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00020 Citrate cycle (TCA cycle) # KEGG_Pathway ko00480 Glutathione metabolism # KEGG_Pathway ko00720 Carbon fixation pathways in prokaryotes # KEGG_Pathway ko04146 Peroxisome # Organism IDH_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11835 PTHR11835; 3 # PATRIC 32117521 VBIEscCol129921_1183 # PDB 1AI2 X-ray; 1.90 A; A=1-416 # PDB 1AI3 X-ray; 1.90 A; A=1-416 # PDB 1BL5 X-ray; 2.50 A; A=3-416 # PDB 1CW1 X-ray; 2.10 A; A=1-416 # PDB 1CW4 X-ray; 2.10 A; A=1-416 # PDB 1CW7 X-ray; 2.60 A; A=1-416 # PDB 1GRO X-ray; 2.50 A; A=1-416 # PDB 1GRP X-ray; 2.50 A; A=1-416 # PDB 1HJ6 X-ray; 2.00 A; A=1-416 # PDB 1IDC X-ray; 2.50 A; A=1-416 # PDB 1IDD X-ray; 2.50 A; A=1-416 # PDB 1IDE X-ray; 2.50 A; A=1-416 # PDB 1IDF X-ray; 2.50 A; A=1-416 # PDB 1IKA X-ray; 2.70 A; A=1-416 # PDB 1ISO X-ray; 1.90 A; A=1-416 # PDB 1P8F X-ray; 1.85 A; A=1-416 # PDB 1PB1 X-ray; 1.70 A; A=1-416 # PDB 1PB3 X-ray; 1.70 A; A=1-416 # PDB 1SJS X-ray; 2.42 A; A=1-416 # PDB 3ICD X-ray; 2.50 A; A=1-416 # PDB 3LCB X-ray; 2.90 A; C/D=1-416 # PDB 4AJ3 X-ray; 1.90 A; A=1-416 # PDB 4AJA X-ray; 1.80 A; A=1-416 # PDB 4AJB X-ray; 1.90 A; A=1-416 # PDB 4AJC X-ray; 2.30 A; A=1-416 # PDB 4AJR X-ray; 2.69 A; A=1-416 # PDB 4AJS X-ray; 1.80 A; A=1-416 # PDB 4BNP X-ray; 2.00 A; A=1-416 # PDB 4ICD X-ray; 2.50 A; A=1-416 # PDB 4P69 X-ray; 3.30 A; C/D=2-416 # PDB 5ICD X-ray; 2.50 A; A=1-416 # PDB 6ICD X-ray; 2.80 A; A=1-416 # PDB 7ICD X-ray; 2.40 A; A=1-416 # PDB 8ICD X-ray; 2.50 A; A=1-416 # PDB 9ICD X-ray; 2.50 A; A=1-416 # PIR A28482 DCECIS # PROSITE PS00470 IDH_IMDH # PTM IDH_ECOLI Phosphorylation state of this enzyme is controlled by isocitrate dehydrogenase kinase/phosphatase (AceK). {ECO 0000269|PubMed 2204109}. # PTM IDH_ECOLI Succinylation probably inhibits enzymatic activity. {ECO 0000269|PubMed 21151122}. # Pfam PF00180 Iso_dh # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName IDH_ECOLI Isocitrate dehydrogenase [NADP] # RefSeq NP_415654 NC_000913.3 # RefSeq WP_000444484 NZ_CP010440.1 # SIMILARITY Belongs to the isocitrate and isopropylmalate dehydrogenases family. {ECO 0000305}. # SMART SM01329 Iso_dh # SUBUNIT IDH_ECOLI Homodimer. {ECO 0000269|PubMed 11284679, ECO 0000269|PubMed 2204109, ECO 0000269|PubMed 2682654, ECO 0000269|PubMed 7761851}. # TIGRFAMs TIGR00183 prok_nadp_idh # eggNOG COG0538 LUCA # eggNOG ENOG4108HMX Bacteria BLAST swissprot:IDH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:IDH_ECOLI BioCyc ECOL316407:JW1122-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1122-MONOMER BioCyc EcoCyc:ISOCITDEH-SUBUNIT http://biocyc.org/getid?id=EcoCyc:ISOCITDEH-SUBUNIT BioCyc MetaCyc:ISOCITDEH-SUBUNIT http://biocyc.org/getid?id=MetaCyc:ISOCITDEH-SUBUNIT COG COG0538 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0538 DIP DIP-10006N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10006N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1999.3195 http://dx.doi.org/10.1006/jmbi.1999.3195 DOI 10.1021/bi00001a046 http://dx.doi.org/10.1021/bi00001a046 DOI 10.1021/bi002533q http://dx.doi.org/10.1021/bi002533q DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nchembio.495 http://dx.doi.org/10.1038/nchembio.495 DOI 10.1073/pnas.86.22.8635 http://dx.doi.org/10.1073/pnas.86.22.8635 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.2204109 http://dx.doi.org/10.1126/science.2204109 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1126/science.7761851 http://dx.doi.org/10.1126/science.7761851 EC_number EC:1.1.1.42 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.42 EMBL AF017587 http://www.ebi.ac.uk/ena/data/view/AF017587 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J02799 http://www.ebi.ac.uk/ena/data/view/J02799 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.1.1.42 http://enzyme.expasy.org/EC/1.1.1.42 EchoBASE EB0484 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0484 EcoGene EG10009 http://www.ecogene.org/geneInfo.php?eg_id=EG10009 EcoGene EG10489 http://www.ecogene.org/geneInfo.php?eg_id=EG10489 EnsemblBacteria AAC74220 http://www.ensemblgenomes.org/id/AAC74220 EnsemblBacteria AAC74220 http://www.ensemblgenomes.org/id/AAC74220 EnsemblBacteria BAA35958 http://www.ensemblgenomes.org/id/BAA35958 EnsemblBacteria BAA35958 http://www.ensemblgenomes.org/id/BAA35958 EnsemblBacteria BAA35958 http://www.ensemblgenomes.org/id/BAA35958 EnsemblBacteria b1136 http://www.ensemblgenomes.org/id/b1136 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0004450 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004450 GO_function GO:0051287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051287 GO_process GO:0006097 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006097 GO_process GO:0006099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006099 GO_process GO:0006979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979 GO_process GO:0022900 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022900 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.718.10 http://www.cathdb.info/version/latest/superfamily/3.40.718.10 GeneID 945702 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945702 HOGENOM HOG000021113 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000021113&db=HOGENOM6 InParanoid P08200 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P08200 IntAct P08200 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P08200* IntEnz 1.1.1.42 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.42 InterPro IPR001804 http://www.ebi.ac.uk/interpro/entry/IPR001804 InterPro IPR004439 http://www.ebi.ac.uk/interpro/entry/IPR004439 InterPro IPR019818 http://www.ebi.ac.uk/interpro/entry/IPR019818 InterPro IPR024084 http://www.ebi.ac.uk/interpro/entry/IPR024084 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1122 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1122 KEGG_Gene eco:b1136 http://www.genome.jp/dbget-bin/www_bget?eco:b1136 KEGG_Orthology KO:K00031 http://www.genome.jp/dbget-bin/www_bget?KO:K00031 KEGG_Pathway ko00020 http://www.genome.jp/kegg-bin/show_pathway?ko00020 KEGG_Pathway ko00480 http://www.genome.jp/kegg-bin/show_pathway?ko00480 KEGG_Pathway ko00720 http://www.genome.jp/kegg-bin/show_pathway?ko00720 KEGG_Pathway ko04146 http://www.genome.jp/kegg-bin/show_pathway?ko04146 KEGG_Reaction rn:R00267 http://www.genome.jp/dbget-bin/www_bget?rn:R00267 KEGG_Reaction rn:R00268 http://www.genome.jp/dbget-bin/www_bget?rn:R00268 KEGG_Reaction rn:R01899 http://www.genome.jp/dbget-bin/www_bget?rn:R01899 OMA TERESWI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TERESWI PANTHER PTHR11835 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11835 PDB 1AI2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1AI2 PDB 1AI3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1AI3 PDB 1BL5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1BL5 PDB 1CW1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1CW1 PDB 1CW4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1CW4 PDB 1CW7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1CW7 PDB 1GRO http://www.ebi.ac.uk/pdbe-srv/view/entry/1GRO PDB 1GRP http://www.ebi.ac.uk/pdbe-srv/view/entry/1GRP PDB 1HJ6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1HJ6 PDB 1IDC http://www.ebi.ac.uk/pdbe-srv/view/entry/1IDC PDB 1IDD http://www.ebi.ac.uk/pdbe-srv/view/entry/1IDD PDB 1IDE http://www.ebi.ac.uk/pdbe-srv/view/entry/1IDE PDB 1IDF http://www.ebi.ac.uk/pdbe-srv/view/entry/1IDF PDB 1IKA http://www.ebi.ac.uk/pdbe-srv/view/entry/1IKA PDB 1ISO http://www.ebi.ac.uk/pdbe-srv/view/entry/1ISO PDB 1P8F http://www.ebi.ac.uk/pdbe-srv/view/entry/1P8F PDB 1PB1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1PB1 PDB 1PB3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1PB3 PDB 1SJS http://www.ebi.ac.uk/pdbe-srv/view/entry/1SJS PDB 3ICD http://www.ebi.ac.uk/pdbe-srv/view/entry/3ICD PDB 3LCB http://www.ebi.ac.uk/pdbe-srv/view/entry/3LCB PDB 4AJ3 http://www.ebi.ac.uk/pdbe-srv/view/entry/4AJ3 PDB 4AJA http://www.ebi.ac.uk/pdbe-srv/view/entry/4AJA PDB 4AJB http://www.ebi.ac.uk/pdbe-srv/view/entry/4AJB PDB 4AJC http://www.ebi.ac.uk/pdbe-srv/view/entry/4AJC PDB 4AJR http://www.ebi.ac.uk/pdbe-srv/view/entry/4AJR PDB 4AJS http://www.ebi.ac.uk/pdbe-srv/view/entry/4AJS PDB 4BNP http://www.ebi.ac.uk/pdbe-srv/view/entry/4BNP PDB 4ICD http://www.ebi.ac.uk/pdbe-srv/view/entry/4ICD PDB 4P69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4P69 PDB 5ICD http://www.ebi.ac.uk/pdbe-srv/view/entry/5ICD PDB 6ICD http://www.ebi.ac.uk/pdbe-srv/view/entry/6ICD PDB 7ICD http://www.ebi.ac.uk/pdbe-srv/view/entry/7ICD PDB 8ICD http://www.ebi.ac.uk/pdbe-srv/view/entry/8ICD PDB 9ICD http://www.ebi.ac.uk/pdbe-srv/view/entry/9ICD PDBsum 1AI2 http://www.ebi.ac.uk/pdbsum/1AI2 PDBsum 1AI3 http://www.ebi.ac.uk/pdbsum/1AI3 PDBsum 1BL5 http://www.ebi.ac.uk/pdbsum/1BL5 PDBsum 1CW1 http://www.ebi.ac.uk/pdbsum/1CW1 PDBsum 1CW4 http://www.ebi.ac.uk/pdbsum/1CW4 PDBsum 1CW7 http://www.ebi.ac.uk/pdbsum/1CW7 PDBsum 1GRO http://www.ebi.ac.uk/pdbsum/1GRO PDBsum 1GRP http://www.ebi.ac.uk/pdbsum/1GRP PDBsum 1HJ6 http://www.ebi.ac.uk/pdbsum/1HJ6 PDBsum 1IDC http://www.ebi.ac.uk/pdbsum/1IDC PDBsum 1IDD http://www.ebi.ac.uk/pdbsum/1IDD PDBsum 1IDE http://www.ebi.ac.uk/pdbsum/1IDE PDBsum 1IDF http://www.ebi.ac.uk/pdbsum/1IDF PDBsum 1IKA http://www.ebi.ac.uk/pdbsum/1IKA PDBsum 1ISO http://www.ebi.ac.uk/pdbsum/1ISO PDBsum 1P8F http://www.ebi.ac.uk/pdbsum/1P8F PDBsum 1PB1 http://www.ebi.ac.uk/pdbsum/1PB1 PDBsum 1PB3 http://www.ebi.ac.uk/pdbsum/1PB3 PDBsum 1SJS http://www.ebi.ac.uk/pdbsum/1SJS PDBsum 3ICD http://www.ebi.ac.uk/pdbsum/3ICD PDBsum 3LCB http://www.ebi.ac.uk/pdbsum/3LCB PDBsum 4AJ3 http://www.ebi.ac.uk/pdbsum/4AJ3 PDBsum 4AJA http://www.ebi.ac.uk/pdbsum/4AJA PDBsum 4AJB http://www.ebi.ac.uk/pdbsum/4AJB PDBsum 4AJC http://www.ebi.ac.uk/pdbsum/4AJC PDBsum 4AJR http://www.ebi.ac.uk/pdbsum/4AJR PDBsum 4AJS http://www.ebi.ac.uk/pdbsum/4AJS PDBsum 4BNP http://www.ebi.ac.uk/pdbsum/4BNP PDBsum 4ICD http://www.ebi.ac.uk/pdbsum/4ICD PDBsum 4P69 http://www.ebi.ac.uk/pdbsum/4P69 PDBsum 5ICD http://www.ebi.ac.uk/pdbsum/5ICD PDBsum 6ICD http://www.ebi.ac.uk/pdbsum/6ICD PDBsum 7ICD http://www.ebi.ac.uk/pdbsum/7ICD PDBsum 8ICD http://www.ebi.ac.uk/pdbsum/8ICD PDBsum 9ICD http://www.ebi.ac.uk/pdbsum/9ICD PROSITE PS00470 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00470 PSORT swissprot:IDH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:IDH_ECOLI PSORT-B swissprot:IDH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:IDH_ECOLI PSORT2 swissprot:IDH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:IDH_ECOLI Pfam PF00180 http://pfam.xfam.org/family/PF00180 Phobius swissprot:IDH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:IDH_ECOLI PhylomeDB P08200 http://phylomedb.org/?seqid=P08200 ProteinModelPortal P08200 http://www.proteinmodelportal.org/query/uniprot/P08200 PubMed 10623532 http://www.ncbi.nlm.nih.gov/pubmed/10623532 PubMed 11284679 http://www.ncbi.nlm.nih.gov/pubmed/11284679 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 21151122 http://www.ncbi.nlm.nih.gov/pubmed/21151122 PubMed 2204109 http://www.ncbi.nlm.nih.gov/pubmed/2204109 PubMed 2682654 http://www.ncbi.nlm.nih.gov/pubmed/2682654 PubMed 3112144 http://www.ncbi.nlm.nih.gov/pubmed/3112144 PubMed 7761851 http://www.ncbi.nlm.nih.gov/pubmed/7761851 PubMed 7819221 http://www.ncbi.nlm.nih.gov/pubmed/7819221 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9352899 http://www.ncbi.nlm.nih.gov/pubmed/9352899 RefSeq NP_415654 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415654 RefSeq WP_000444484 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000444484 SMART SM01329 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01329 SMR P08200 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P08200 STRING 511145.b1136 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1136&targetmode=cogs STRING COG0538 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0538&targetmode=cogs SWISS-2DPAGE P08200 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P08200 TIGRFAMs TIGR00183 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00183 UniProtKB IDH_ECOLI http://www.uniprot.org/uniprot/IDH_ECOLI UniProtKB-AC P08200 http://www.uniprot.org/uniprot/P08200 charge swissprot:IDH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:IDH_ECOLI eggNOG COG0538 http://eggnogapi.embl.de/nog_data/html/tree/COG0538 eggNOG ENOG4108HMX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108HMX epestfind swissprot:IDH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:IDH_ECOLI garnier swissprot:IDH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:IDH_ECOLI helixturnhelix swissprot:IDH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:IDH_ECOLI hmoment swissprot:IDH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:IDH_ECOLI iep swissprot:IDH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:IDH_ECOLI inforesidue swissprot:IDH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:IDH_ECOLI octanol swissprot:IDH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:IDH_ECOLI pepcoil swissprot:IDH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:IDH_ECOLI pepdigest swissprot:IDH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:IDH_ECOLI pepinfo swissprot:IDH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:IDH_ECOLI pepnet swissprot:IDH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:IDH_ECOLI pepstats swissprot:IDH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:IDH_ECOLI pepwheel swissprot:IDH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:IDH_ECOLI pepwindow swissprot:IDH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:IDH_ECOLI sigcleave swissprot:IDH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:IDH_ECOLI ## Database ID URL or Descriptions # AltName CILA_ECOLI Citrate (pro-3S)-lyase alpha chain # AltName CILA_ECOLI Citrate CoA-transferase subunit # BioGrid 4261998 5 # CATALYTIC ACTIVITY CILA_ECOLI Acetyl-CoA + citrate = acetate + (3S)-citryl- CoA. # CATALYTIC ACTIVITY CILA_ECOLI Citrate = acetate + oxaloacetate. # EcoGene EG13541 citF # FUNCTION CILA_ECOLI Represents a citrate acetyl-ACP transferase. {ECO 0000250}. # GO_component GO:0009346 citrate lyase complex; IEA:InterPro. # GO_function GO:0008814 citrate CoA-transferase activity; IEA:UniProtKB-EC. # GO_function GO:0008815 citrate (pro-3S)-lyase activity; IEA:UniProtKB-EC. # GO_process GO:0006084 acetyl-CoA metabolic process; IEA:InterPro. # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0051186 cofactor metabolic process # INDUCTION Repressed by H-NS. Part of the citCDEFXG operon. {ECO:0000269|PubMed 19429622}. # InterPro IPR006472 Citrate_lyase_asu # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00020 Citrate cycle (TCA cycle) # KEGG_Pathway ko02020 Two-component system # Organism CILA_ECOLI Escherichia coli (strain K12) # PATRIC 32116410 VBIEscCol129921_0645 # PIR E64795 E64795 # PIRSF PIRSF009451 Citrt_lyas_alpha # Pfam PF04223 CitF # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CILA_ECOLI Citrate lyase alpha chain # RefSeq NP_415148 NC_000913.3 # RefSeq WP_000192242 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40815.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SUBCELLULAR LOCATION CILA_ECOLI Cytoplasm. # SUBUNIT Oligomer with a subunit composition of (alpha,beta, gamma)6. {ECO 0000250}. # TIGRFAMs TIGR01584 citF # eggNOG COG3051 LUCA # eggNOG ENOG4105CHY Bacteria BLAST swissprot:CILA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CILA_ECOLI BioCyc ECOL316407:JW5087-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5087-MONOMER BioCyc EcoCyc:CITTRANS-MONOMER http://biocyc.org/getid?id=EcoCyc:CITTRANS-MONOMER BioCyc MetaCyc:CITTRANS-MONOMER http://biocyc.org/getid?id=MetaCyc:CITTRANS-MONOMER COG COG3051 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3051 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00108-09 http://dx.doi.org/10.1128/JB.00108-09 EC_number EC:2.8.3.10 http://www.genome.jp/dbget-bin/www_bget?EC:2.8.3.10 EC_number EC:4.1.3.6 http://www.genome.jp/dbget-bin/www_bget?EC:4.1.3.6 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 ENZYME 2.8.3.10 http://enzyme.expasy.org/EC/2.8.3.10 ENZYME 4.1.3.6 http://enzyme.expasy.org/EC/4.1.3.6 EchoBASE EB3311 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3311 EcoGene EG13541 http://www.ecogene.org/geneInfo.php?eg_id=EG13541 EnsemblBacteria AAC73716 http://www.ensemblgenomes.org/id/AAC73716 EnsemblBacteria AAC73716 http://www.ensemblgenomes.org/id/AAC73716 EnsemblBacteria BAA35251 http://www.ensemblgenomes.org/id/BAA35251 EnsemblBacteria BAA35251 http://www.ensemblgenomes.org/id/BAA35251 EnsemblBacteria BAA35251 http://www.ensemblgenomes.org/id/BAA35251 EnsemblBacteria b0615 http://www.ensemblgenomes.org/id/b0615 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009346 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009346 GO_function GO:0008814 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008814 GO_function GO:0008815 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008815 GO_process GO:0006084 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006084 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GeneID 945230 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945230 HOGENOM HOG000117923 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117923&db=HOGENOM6 InParanoid P75726 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75726 IntEnz 2.8.3.10 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.8.3.10 IntEnz 4.1.3.6 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.3.6 InterPro IPR006472 http://www.ebi.ac.uk/interpro/entry/IPR006472 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5087 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5087 KEGG_Gene eco:b0615 http://www.genome.jp/dbget-bin/www_bget?eco:b0615 KEGG_Orthology KO:K01643 http://www.genome.jp/dbget-bin/www_bget?KO:K01643 KEGG_Pathway ko00020 http://www.genome.jp/kegg-bin/show_pathway?ko00020 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 KEGG_Reaction rn:R00362 http://www.genome.jp/dbget-bin/www_bget?rn:R00362 OMA KGSVINQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KGSVINQ PSORT swissprot:CILA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CILA_ECOLI PSORT-B swissprot:CILA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CILA_ECOLI PSORT2 swissprot:CILA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CILA_ECOLI Pfam PF04223 http://pfam.xfam.org/family/PF04223 Phobius swissprot:CILA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CILA_ECOLI PhylomeDB P75726 http://phylomedb.org/?seqid=P75726 ProteinModelPortal P75726 http://www.proteinmodelportal.org/query/uniprot/P75726 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19429622 http://www.ncbi.nlm.nih.gov/pubmed/19429622 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415148 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415148 RefSeq WP_000192242 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000192242 SMR P75726 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75726 STRING 511145.b0615 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0615&targetmode=cogs STRING COG3051 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3051&targetmode=cogs TIGRFAMs TIGR01584 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01584 UniProtKB CILA_ECOLI http://www.uniprot.org/uniprot/CILA_ECOLI UniProtKB-AC P75726 http://www.uniprot.org/uniprot/P75726 charge swissprot:CILA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CILA_ECOLI eggNOG COG3051 http://eggnogapi.embl.de/nog_data/html/tree/COG3051 eggNOG ENOG4105CHY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CHY epestfind swissprot:CILA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CILA_ECOLI garnier swissprot:CILA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CILA_ECOLI helixturnhelix swissprot:CILA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CILA_ECOLI hmoment swissprot:CILA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CILA_ECOLI iep swissprot:CILA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CILA_ECOLI inforesidue swissprot:CILA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CILA_ECOLI octanol swissprot:CILA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CILA_ECOLI pepcoil swissprot:CILA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CILA_ECOLI pepdigest swissprot:CILA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CILA_ECOLI pepinfo swissprot:CILA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CILA_ECOLI pepnet swissprot:CILA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CILA_ECOLI pepstats swissprot:CILA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CILA_ECOLI pepwheel swissprot:CILA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CILA_ECOLI pepwindow swissprot:CILA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CILA_ECOLI sigcleave swissprot:CILA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CILA_ECOLI ## Database ID URL or Descriptions # AltName ABGB_ECOLI PABA-GLU hydrolase # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=60 uM for PABA-GLU (at pH 8.5) {ECO 0000269|PubMed:20190044}; # BioGrid 4260157 20 # CDD cd05673 M20_Acy1L2_AbgB # COFACTOR ABGB_ECOLI Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 20190044}; # EcoGene EG13351 abgB # FUNCTION ABGB_ECOLI Component of the p-aminobenzoyl-glutamate hydrolase multicomponent enzyme system which catalyzes the cleavage of p- aminobenzoyl-glutamate (PABA-GLU) to form p-aminobenzoate (PABA) and glutamate. AbgAB does not degrade dipeptides and the physiological role of abgABT should be clarified. {ECO 0000269|PubMed 17307853, ECO 0000269|PubMed 20190044}. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_function GO:0046982 protein heterodimerization activity; IPI:EcoliWiki. # GO_function GO:0071713 para-aminobenzoyl-glutamate hydrolase activity; IDA:UniProtKB. # GO_process GO:0046657 folic acid catabolic process; IGI:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.30.70.360 -; 1. # INDUCTION Could be transcriptionally regulated by AbgR. {ECO:0000269|PubMed 9829935}. # INTERACTION ABGB_ECOLI P77357 abgA; NbExp=2; IntAct=EBI-1123629, EBI-9155452; # IntAct P76052 6 # InterPro IPR002933 Peptidase_M20 # InterPro IPR011650 Peptidase_M20_dimer # InterPro IPR017145 Aminobenzoyl-glu_utiliz_pB # InterPro IPR017439 Amidohydrolase # KEGG_Brite ko01002 Peptidases # Organism ABGB_ECOLI Escherichia coli (strain K12) # PATRIC 32117950 VBIEscCol129921_1395 # PIR D64883 D64883 # PIRSF PIRSF037227 Aminobenzoyl-glu_utiliz_pB # Pfam PF01546 Peptidase_M20 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ABGB_ECOLI p-aminobenzoyl-glutamate hydrolase subunit B # RefSeq NP_415853 NC_000913.3 # RefSeq WP_001156451 NZ_LN832404.1 # SUBUNIT Forms a heterodimer with AbgA. {ECO:0000269|PubMed 20190044}. # SUPFAM SSF55031 SSF55031 # TIGRFAMs TIGR01891 amidohydrolases # eggNOG COG1473 LUCA # eggNOG ENOG4107RT5 Bacteria BLAST swissprot:ABGB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ABGB_ECOLI BioCyc ECOL316407:JW1331-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1331-MONOMER BioCyc EcoCyc:G6669-MONOMER http://biocyc.org/getid?id=EcoCyc:G6669-MONOMER BioCyc MetaCyc:G6669-MONOMER http://biocyc.org/getid?id=MetaCyc:G6669-MONOMER COG COG1473 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1473 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01362-09 http://dx.doi.org/10.1128/JB.01362-09 DOI 10.1128/JB.01940-06 http://dx.doi.org/10.1128/JB.01940-06 EC_number EC:3.5.1.- http://www.genome.jp/dbget-bin/www_bget?EC:3.5.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.5.1.- http://enzyme.expasy.org/EC/3.5.1.- EchoBASE EB3134 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3134 EcoGene EG13351 http://www.ecogene.org/geneInfo.php?eg_id=EG13351 EnsemblBacteria AAC74419 http://www.ensemblgenomes.org/id/AAC74419 EnsemblBacteria AAC74419 http://www.ensemblgenomes.org/id/AAC74419 EnsemblBacteria BAE76404 http://www.ensemblgenomes.org/id/BAE76404 EnsemblBacteria BAE76404 http://www.ensemblgenomes.org/id/BAE76404 EnsemblBacteria BAE76404 http://www.ensemblgenomes.org/id/BAE76404 EnsemblBacteria b1337 http://www.ensemblgenomes.org/id/b1337 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0046982 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046982 GO_function GO:0071713 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071713 GO_process GO:0046657 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046657 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.30.70.360 http://www.cathdb.info/version/latest/superfamily/3.30.70.360 GeneID 945950 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945950 HOGENOM HOG000251262 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000251262&db=HOGENOM6 InParanoid P76052 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76052 IntAct P76052 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76052* IntEnz 3.5.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.1 InterPro IPR002933 http://www.ebi.ac.uk/interpro/entry/IPR002933 InterPro IPR011650 http://www.ebi.ac.uk/interpro/entry/IPR011650 InterPro IPR017145 http://www.ebi.ac.uk/interpro/entry/IPR017145 InterPro IPR017439 http://www.ebi.ac.uk/interpro/entry/IPR017439 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW1331 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1331 KEGG_Gene eco:b1337 http://www.genome.jp/dbget-bin/www_bget?eco:b1337 KEGG_Orthology KO:K12941 http://www.genome.jp/dbget-bin/www_bget?KO:K12941 OMA HYAITDT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HYAITDT PSORT swissprot:ABGB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ABGB_ECOLI PSORT-B swissprot:ABGB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ABGB_ECOLI PSORT2 swissprot:ABGB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ABGB_ECOLI Pfam PF01546 http://pfam.xfam.org/family/PF01546 Phobius swissprot:ABGB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ABGB_ECOLI PhylomeDB P76052 http://phylomedb.org/?seqid=P76052 ProteinModelPortal P76052 http://www.proteinmodelportal.org/query/uniprot/P76052 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17307853 http://www.ncbi.nlm.nih.gov/pubmed/17307853 PubMed 20190044 http://www.ncbi.nlm.nih.gov/pubmed/20190044 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9829935 http://www.ncbi.nlm.nih.gov/pubmed/9829935 RefSeq NP_415853 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415853 RefSeq WP_001156451 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001156451 STRING 511145.b1337 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1337&targetmode=cogs STRING COG1473 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1473&targetmode=cogs SUPFAM SSF55031 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55031 TIGRFAMs TIGR01891 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01891 UniProtKB ABGB_ECOLI http://www.uniprot.org/uniprot/ABGB_ECOLI UniProtKB-AC P76052 http://www.uniprot.org/uniprot/P76052 charge swissprot:ABGB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ABGB_ECOLI eggNOG COG1473 http://eggnogapi.embl.de/nog_data/html/tree/COG1473 eggNOG ENOG4107RT5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107RT5 epestfind swissprot:ABGB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ABGB_ECOLI garnier swissprot:ABGB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ABGB_ECOLI helixturnhelix swissprot:ABGB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ABGB_ECOLI hmoment swissprot:ABGB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ABGB_ECOLI iep swissprot:ABGB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ABGB_ECOLI inforesidue swissprot:ABGB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ABGB_ECOLI octanol swissprot:ABGB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ABGB_ECOLI pepcoil swissprot:ABGB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ABGB_ECOLI pepdigest swissprot:ABGB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ABGB_ECOLI pepinfo swissprot:ABGB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ABGB_ECOLI pepnet swissprot:ABGB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ABGB_ECOLI pepstats swissprot:ABGB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ABGB_ECOLI pepwheel swissprot:ABGB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ABGB_ECOLI pepwindow swissprot:ABGB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ABGB_ECOLI sigcleave swissprot:ABGB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ABGB_ECOLI ## Database ID URL or Descriptions # EcoGene EG40012 insL1 # FUNCTION INSL1_ECOLI Involved in the transposition of the insertion sequence IS186. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 3.90.350.10 -; 1. # InterPro IPR002559 Transposase_11 # InterPro IPR012337 RNaseH-like_dom # InterPro IPR014736 Transposase_Tn5-like_core # Organism INSL1_ECOLI Escherichia coli (strain K12) # PIR G65013 QQEC47 # Pfam PF01609 DDE_Tnp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSL1_ECOLI Putative transposase InsL for insertion sequence element IS186A # RefSeq NP_414557 NC_000913.3 # RefSeq NP_415114 NC_000913.3 # RefSeq NP_416895 NC_000913.3 # RefSeq WP_001300563 NZ_LN832404.1 # SIMILARITY Belongs to the transposase 11 family. {ECO 0000305}. # SUPFAM SSF53098 SSF53098 # eggNOG COG3385 LUCA # eggNOG ENOG4108SER Bacteria BLAST swissprot:INSL1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSL1_ECOLI BioCyc EcoCyc:G6083-MONOMER http://biocyc.org/getid?id=EcoCyc:G6083-MONOMER DOI 10.1016/0014-5793(85)80040-5 http://dx.doi.org/10.1016/0014-5793(85)80040-5 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M11300 http://www.ebi.ac.uk/ena/data/view/M11300 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X03123 http://www.ebi.ac.uk/ena/data/view/X03123 EchoBASE EB4748 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4748 EcoGene EG40012 http://www.ecogene.org/geneInfo.php?eg_id=EG40012 EnsemblBacteria AAC73127 http://www.ensemblgenomes.org/id/AAC73127 EnsemblBacteria AAC73127 http://www.ensemblgenomes.org/id/AAC73127 EnsemblBacteria BAE76030 http://www.ensemblgenomes.org/id/BAE76030 EnsemblBacteria BAE76030 http://www.ensemblgenomes.org/id/BAE76030 EnsemblBacteria BAE76030 http://www.ensemblgenomes.org/id/BAE76030 EnsemblBacteria b0016 http://www.ensemblgenomes.org/id/b0016 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 3.90.350.10 http://www.cathdb.info/version/latest/superfamily/3.90.350.10 GeneID 944754 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944754 GeneID 945200 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945200 GeneID 946896 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946896 InParanoid P0CF91 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CF91 InterPro IPR002559 http://www.ebi.ac.uk/interpro/entry/IPR002559 InterPro IPR012337 http://www.ebi.ac.uk/interpro/entry/IPR012337 InterPro IPR014736 http://www.ebi.ac.uk/interpro/entry/IPR014736 KEGG_Gene ecj:JW0015 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0015 KEGG_Gene eco:b0016 http://www.genome.jp/dbget-bin/www_bget?eco:b0016 KEGG_Gene eco:b0582 http://www.genome.jp/dbget-bin/www_bget?eco:b0582 KEGG_Gene eco:b2394 http://www.genome.jp/dbget-bin/www_bget?eco:b2394 OMA EIHIADR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EIHIADR PSORT swissprot:INSL1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSL1_ECOLI PSORT-B swissprot:INSL1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSL1_ECOLI PSORT2 swissprot:INSL1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSL1_ECOLI Pfam PF01609 http://pfam.xfam.org/family/PF01609 Phobius swissprot:INSL1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSL1_ECOLI ProteinModelPortal P0CF91 http://www.proteinmodelportal.org/query/uniprot/P0CF91 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2996940 http://www.ncbi.nlm.nih.gov/pubmed/2996940 PubMed 2997142 http://www.ncbi.nlm.nih.gov/pubmed/2997142 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414557 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414557 RefSeq NP_415114 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415114 RefSeq NP_416895 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416895 RefSeq WP_001300563 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300563 STRING 511145.b2394 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2394&targetmode=cogs SUPFAM SSF53098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098 UniProtKB INSL1_ECOLI http://www.uniprot.org/uniprot/INSL1_ECOLI UniProtKB-AC P0CF91 http://www.uniprot.org/uniprot/P0CF91 charge swissprot:INSL1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSL1_ECOLI eggNOG COG3385 http://eggnogapi.embl.de/nog_data/html/tree/COG3385 eggNOG ENOG4108SER http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108SER epestfind swissprot:INSL1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSL1_ECOLI garnier swissprot:INSL1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSL1_ECOLI helixturnhelix swissprot:INSL1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSL1_ECOLI hmoment swissprot:INSL1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSL1_ECOLI iep swissprot:INSL1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSL1_ECOLI inforesidue swissprot:INSL1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSL1_ECOLI octanol swissprot:INSL1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSL1_ECOLI pepcoil swissprot:INSL1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSL1_ECOLI pepdigest swissprot:INSL1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSL1_ECOLI pepinfo swissprot:INSL1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSL1_ECOLI pepnet swissprot:INSL1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSL1_ECOLI pepstats swissprot:INSL1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSL1_ECOLI pepwheel swissprot:INSL1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSL1_ECOLI pepwindow swissprot:INSL1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSL1_ECOLI sigcleave swissprot:INSL1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSL1_ECOLI ## Database ID URL or Descriptions # GO_component GO:0009279 cell outer membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # Gene3D 2.160.20.20 -; 1. # Gene3D 2.40.128.130 -; 1. # InterPro IPR004899 Pertactin_central # InterPro IPR005546 Autotransporte_beta # InterPro IPR006315 OM_autotransptr_brl # InterPro IPR011050 Pectin_lyase_fold/virulence # InterPro IPR012332 P22_tailspike_C-like # Organism YUAQ_ECOLI Escherichia coli (strain K12) # PROSITE PS51208 AUTOTRANSPORTER # Pfam PF03212 Pertactin # Pfam PF03797 Autotransporter # RecName YUAQ_ECOLI Uncharacterized protein YuaQ # RefSeq NP_061407 NC_002483.1 # RefSeq WP_000995793 NZ_CP014273.1 # SIMILARITY Contains 1 autotransporter (TC 1.B.12) domain. {ECO:0000255|PROSITE-ProRule PRU00556}. # SMART SM00869 Autotransporter # SUBCELLULAR LOCATION YUAQ_ECOLI Cell outer membrane {ECO 0000305}; Peripheral membrane protein {ECO 0000305}. # SUPFAM SSF103515 SSF103515 # SUPFAM SSF51126 SSF51126 # TIGRFAMs TIGR01414 autotrans_barl BLAST swissprot:YUAQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YUAQ_ECOLI EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 Gene3D 2.160.20.20 http://www.cathdb.info/version/latest/superfamily/2.160.20.20 Gene3D 2.40.128.130 http://www.cathdb.info/version/latest/superfamily/2.40.128.130 GeneID 1263499 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263499 InterPro IPR004899 http://www.ebi.ac.uk/interpro/entry/IPR004899 InterPro IPR005546 http://www.ebi.ac.uk/interpro/entry/IPR005546 InterPro IPR006315 http://www.ebi.ac.uk/interpro/entry/IPR006315 InterPro IPR011050 http://www.ebi.ac.uk/interpro/entry/IPR011050 InterPro IPR012332 http://www.ebi.ac.uk/interpro/entry/IPR012332 OMA DGNSAIK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DGNSAIK PROSITE PS51208 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51208 PSORT swissprot:YUAQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YUAQ_ECOLI PSORT-B swissprot:YUAQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YUAQ_ECOLI PSORT2 swissprot:YUAQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YUAQ_ECOLI Pfam PF03212 http://pfam.xfam.org/family/PF03212 Pfam PF03797 http://pfam.xfam.org/family/PF03797 Phobius swissprot:YUAQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YUAQ_ECOLI PhylomeDB Q9JMS3 http://phylomedb.org/?seqid=Q9JMS3 ProteinModelPortal Q9JMS3 http://www.proteinmodelportal.org/query/uniprot/Q9JMS3 RefSeq NP_061407 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061407 RefSeq WP_000995793 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000995793 SMART SM00869 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00869 SMR Q9JMS3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9JMS3 SUPFAM SSF103515 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103515 SUPFAM SSF51126 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51126 TIGRFAMs TIGR01414 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01414 UniProtKB YUAQ_ECOLI http://www.uniprot.org/uniprot/YUAQ_ECOLI UniProtKB-AC Q9JMS3 http://www.uniprot.org/uniprot/Q9JMS3 charge swissprot:YUAQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YUAQ_ECOLI epestfind swissprot:YUAQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YUAQ_ECOLI garnier swissprot:YUAQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YUAQ_ECOLI helixturnhelix swissprot:YUAQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YUAQ_ECOLI hmoment swissprot:YUAQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YUAQ_ECOLI iep swissprot:YUAQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YUAQ_ECOLI inforesidue swissprot:YUAQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YUAQ_ECOLI octanol swissprot:YUAQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YUAQ_ECOLI pepcoil swissprot:YUAQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YUAQ_ECOLI pepdigest swissprot:YUAQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YUAQ_ECOLI pepinfo swissprot:YUAQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YUAQ_ECOLI pepnet swissprot:YUAQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YUAQ_ECOLI pepstats swissprot:YUAQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YUAQ_ECOLI pepwheel swissprot:YUAQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YUAQ_ECOLI pepwindow swissprot:YUAQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YUAQ_ECOLI sigcleave swissprot:YUAQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YUAQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4262430 258 # DISRUPTION PHENOTYPE NLPI_ECOLI Highly sensitive to osmotic conditions in low-salt medium and also thermosensitive under low-salt conditions. Shows pronounced filamentation at 42 degree Celsius under low osmolarity, but not at 30 or 37 degrees. Growth in low- salt medium is severely restricted at 30 degrees and no growth is observed at 37 and 42 degree Celsius. Shows increased eDNA production. Produces 100-fold more outer-membrane vesicles making the organism more resistant to toxins, and enhancing survival under stress. Higher sensitivity to ultra high pressure than wild- type counterparts (PubMed 16597971). Strongly represses cell swarming but no effect on cell swimming (PubMed 17122336). {ECO 0000269|PubMed 10400590, ECO 0000269|PubMed 15047720, ECO 0000269|PubMed 16597971, ECO 0000269|PubMed 16855227, ECO 0000269|PubMed 17122336, ECO 0000269|PubMed 17163978, ECO 0000269|PubMed 20833130}. # DrugBank DB03754 Tris # EcoGene EG12371 nlpI # FUNCTION NLPI_ECOLI May be involved in cell division. May play a role in bacterial septation or regulation of cell wall degradation during cell division. Negatively controls the production of extracellular DNA (eDNA). {ECO 0000269|PubMed 10400590, ECO 0000269|PubMed 20833130}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_function GO:0030674 protein binding, bridging; IPI:EcoCyc. # GO_process GO:0007049 cell cycle; IEA:UniProtKB-KW. # GO_process GO:0051301 cell division; IMP:EcoCyc. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0030674 protein binding, bridging # GOslim_process GO:0007049 cell cycle # GOslim_process GO:0051301 cell division # Gene3D 1.25.40.10 -; 1. # INDUCTION NLPI_ECOLI By L-arabinose. By high-pressure at 400MPa for 5 minutes. {ECO 0000269|PubMed 10400590, ECO 0000269|PubMed 16597971}. # InterPro IPR011990 TPR-like_helical_dom # InterPro IPR013026 TPR-contain_dom # InterPro IPR013105 TPR_2 # InterPro IPR019734 TPR_repeat # InterPro IPR023605 Lipoprotein_NlpI # MISCELLANEOUS NLPI_ECOLI Processed by Prc protease in the C-terminus. # Organism NLPI_ECOLI Escherichia coli (strain K12) # PATRIC 32121744 VBIEscCol129921_3258 # PDB 1XNF X-ray; 1.98 A; A/B=20-294 # PIR G65106 G65106 # PIRSF PIRSF004654 NlpI # PROSITE PS50005 TPR; 3 # PROSITE PS50293 TPR_REGION; 2 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF07719 TPR_2 # Pfam PF13181 TPR_8 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NLPI_ECOLI Lipoprotein NlpI # RefSeq NP_417632 NC_000913.3 # RefSeq WP_000802080 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=M63288; Type=Frameshift; Positions=Several; Evidence={ECO 0000305}; # SIMILARITY Contains 3 TPR repeats. {ECO:0000255|PROSITE- ProRule PRU00339}. # SMART SM00028 TPR; 3 # SUBCELLULAR LOCATION NLPI_ECOLI Cell membrane; Lipid-anchor. # SUBUNIT NLPI_ECOLI Homodimer. Interacts with Prc and IbpB. {ECO 0000269|PubMed 15047720, ECO 0000269|PubMed 15634341}. # SUPFAM SSF48452 SSF48452 # eggNOG COG4785 LUCA # eggNOG ENOG4105RT1 Bacteria BLAST swissprot:NLPI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NLPI_ECOLI BioCyc ECOL316407:JW3132-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3132-MONOMER BioCyc EcoCyc:EG12371-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12371-MONOMER COG COG4785 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4785 DIP DIP-48051N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48051N DOI 10.1016/j.bbrc.2010.09.026 http://dx.doi.org/10.1016/j.bbrc.2010.09.026 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/jb/mvh022 http://dx.doi.org/10.1093/jb/mvh022 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1111/j.1365-2958.2006.05522.x http://dx.doi.org/10.1111/j.1365-2958.2006.05522.x DOI 10.1111/j.1432-1033.2004.04397.x http://dx.doi.org/10.1111/j.1432-1033.2004.04397.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AEM.72.4.2661-2671.2006 http://dx.doi.org/10.1128/AEM.72.4.2661-2671.2006 DOI 10.1128/JB.00498-06 http://dx.doi.org/10.1128/JB.00498-06 DOI 10.1128/JB.01294-06 http://dx.doi.org/10.1128/JB.01294-06 DrugBank DB03754 http://www.drugbank.ca/drugs/DB03754 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J02638 http://www.ebi.ac.uk/ena/data/view/J02638 EMBL M63288 http://www.ebi.ac.uk/ena/data/view/M63288 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2274 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2274 EcoGene EG12371 http://www.ecogene.org/geneInfo.php?eg_id=EG12371 EnsemblBacteria AAC76197 http://www.ensemblgenomes.org/id/AAC76197 EnsemblBacteria AAC76197 http://www.ensemblgenomes.org/id/AAC76197 EnsemblBacteria BAE77209 http://www.ensemblgenomes.org/id/BAE77209 EnsemblBacteria BAE77209 http://www.ensemblgenomes.org/id/BAE77209 EnsemblBacteria BAE77209 http://www.ensemblgenomes.org/id/BAE77209 EnsemblBacteria b3163 http://www.ensemblgenomes.org/id/b3163 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0030674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030674 GO_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0030674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030674 GOslim_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 Gene3D 1.25.40.10 http://www.cathdb.info/version/latest/superfamily/1.25.40.10 GeneID 947673 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947673 HOGENOM HOG000276076 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276076&db=HOGENOM6 InParanoid P0AFB1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFB1 IntAct P0AFB1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFB1* InterPro IPR011990 http://www.ebi.ac.uk/interpro/entry/IPR011990 InterPro IPR013026 http://www.ebi.ac.uk/interpro/entry/IPR013026 InterPro IPR013105 http://www.ebi.ac.uk/interpro/entry/IPR013105 InterPro IPR019734 http://www.ebi.ac.uk/interpro/entry/IPR019734 InterPro IPR023605 http://www.ebi.ac.uk/interpro/entry/IPR023605 KEGG_Gene ecj:JW3132 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3132 KEGG_Gene eco:b3163 http://www.genome.jp/dbget-bin/www_bget?eco:b3163 KEGG_Orthology KO:K05803 http://www.genome.jp/dbget-bin/www_bget?KO:K05803 OMA YEAFDST http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YEAFDST PDB 1XNF http://www.ebi.ac.uk/pdbe-srv/view/entry/1XNF PDBsum 1XNF http://www.ebi.ac.uk/pdbsum/1XNF PROSITE PS50005 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50005 PROSITE PS50293 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50293 PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:NLPI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NLPI_ECOLI PSORT-B swissprot:NLPI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NLPI_ECOLI PSORT2 swissprot:NLPI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NLPI_ECOLI Pfam PF07719 http://pfam.xfam.org/family/PF07719 Pfam PF13181 http://pfam.xfam.org/family/PF13181 Phobius swissprot:NLPI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NLPI_ECOLI PhylomeDB P0AFB1 http://phylomedb.org/?seqid=P0AFB1 ProteinModelPortal P0AFB1 http://www.proteinmodelportal.org/query/uniprot/P0AFB1 PubMed 10400590 http://www.ncbi.nlm.nih.gov/pubmed/10400590 PubMed 15047720 http://www.ncbi.nlm.nih.gov/pubmed/15047720 PubMed 15634341 http://www.ncbi.nlm.nih.gov/pubmed/15634341 PubMed 16597971 http://www.ncbi.nlm.nih.gov/pubmed/16597971 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16855227 http://www.ncbi.nlm.nih.gov/pubmed/16855227 PubMed 17122336 http://www.ncbi.nlm.nih.gov/pubmed/17122336 PubMed 17163978 http://www.ncbi.nlm.nih.gov/pubmed/17163978 PubMed 2045359 http://www.ncbi.nlm.nih.gov/pubmed/2045359 PubMed 20833130 http://www.ncbi.nlm.nih.gov/pubmed/20833130 PubMed 2432069 http://www.ncbi.nlm.nih.gov/pubmed/2432069 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417632 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417632 RefSeq WP_000802080 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000802080 SMART SM00028 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00028 SMR P0AFB1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFB1 STRING 511145.b3163 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3163&targetmode=cogs STRING COG4785 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4785&targetmode=cogs SUPFAM SSF48452 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48452 UniProtKB NLPI_ECOLI http://www.uniprot.org/uniprot/NLPI_ECOLI UniProtKB-AC P0AFB1 http://www.uniprot.org/uniprot/P0AFB1 charge swissprot:NLPI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NLPI_ECOLI eggNOG COG4785 http://eggnogapi.embl.de/nog_data/html/tree/COG4785 eggNOG ENOG4105RT1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105RT1 epestfind swissprot:NLPI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NLPI_ECOLI garnier swissprot:NLPI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NLPI_ECOLI helixturnhelix swissprot:NLPI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NLPI_ECOLI hmoment swissprot:NLPI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NLPI_ECOLI iep swissprot:NLPI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NLPI_ECOLI inforesidue swissprot:NLPI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NLPI_ECOLI octanol swissprot:NLPI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NLPI_ECOLI pepcoil swissprot:NLPI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NLPI_ECOLI pepdigest swissprot:NLPI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NLPI_ECOLI pepinfo swissprot:NLPI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NLPI_ECOLI pepnet swissprot:NLPI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NLPI_ECOLI pepstats swissprot:NLPI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NLPI_ECOLI pepwheel swissprot:NLPI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NLPI_ECOLI pepwindow swissprot:NLPI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NLPI_ECOLI sigcleave swissprot:NLPI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NLPI_ECOLI ## Database ID URL or Descriptions # AltName KCY_ECOLI Cytidine monophosphate kinase # AltName KCY_ECOLI Protein MssA # AltName KCY_ECOLI p25 # BRENDA 2.7.4.25 2026 # BioGrid 4260009 256 # CATALYTIC ACTIVITY KCY_ECOLI ATP + (d)CMP = ADP + (d)CDP. {ECO 0000269|PubMed 7836281, ECO 0000269|PubMed 9126287}. # EcoGene EG11265 cmk # FUNCTION KCY_ECOLI ATP, dATP, and GTP are equally effective as phosphate donors. CMP and dCMP are the best phosphate acceptors. {ECO 0000269|PubMed 7836281, ECO 0000269|PubMed 8190075}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004127 cytidylate kinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006220 pyrimidine nucleotide metabolic process; IEA:UniProtKB-HAMAP. # GO_process GO:0015949 nucleobase-containing small molecule interconversion; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.300 -; 1. # HAMAP MF_00238 Cytidyl_kinase_type1 # IntAct P0A6I0 6 # InterPro IPR003136 Cytidylate_kin # InterPro IPR011994 Cytidylate_kinase_dom # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00240 Pyrimidine metabolism # Organism KCY_ECOLI Escherichia coli (strain K12) # PATRIC 32117033 VBIEscCol129921_0941 # PDB 1CKE X-ray; 1.75 A; A=1-227 # PDB 1KDO X-ray; 1.90 A; A/B=1-227 # PDB 1KDP X-ray; 2.30 A; A/B=1-227 # PDB 1KDR X-ray; 2.25 A; A/B=1-227 # PDB 1KDT X-ray; 1.95 A; A/B=1-227 # PDB 2CMK X-ray; 2.00 A; A=1-227 # PDB 2FEM X-ray; 1.90 A; A=1-227 # PDB 2FEO X-ray; 2.80 A; A=1-227 # PIR A04448 QQEC31 # PIR E64830 E64830 # Pfam PF02224 Cytidylate_kin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName KCY_ECOLI Cytidylate kinase # RefSeq NP_415430 NC_000913.3 # RefSeq WP_000125016 NZ_LN832404.1 # SIMILARITY Belongs to the cytidylate kinase family. Type 1 subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION KCY_ECOLI Cytoplasm. # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR00017 cmk # eggNOG COG0283 LUCA # eggNOG ENOG4105CAT Bacteria BLAST swissprot:KCY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:KCY_ECOLI BioCyc ECOL316407:JW0893-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0893-MONOMER BioCyc EcoCyc:CMPKI-MONOMER http://biocyc.org/getid?id=EcoCyc:CMPKI-MONOMER BioCyc MetaCyc:CMPKI-MONOMER http://biocyc.org/getid?id=MetaCyc:CMPKI-MONOMER COG COG0283 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0283 DOI 10.1006/abbi.1997.9888 http://dx.doi.org/10.1006/abbi.1997.9888 DOI 10.1007/BF00283870 http://dx.doi.org/10.1007/BF00283870 DOI 10.1007/BF00334105 http://dx.doi.org/10.1007/BF00334105 DOI 10.1016/S0969-2126(98)00150-6 http://dx.doi.org/10.1016/S0969-2126(98)00150-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/10.6.1857 http://dx.doi.org/10.1093/nar/10.6.1857 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.4.25 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.4.25 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00352 http://www.ebi.ac.uk/ena/data/view/V00352 EMBL X00785 http://www.ebi.ac.uk/ena/data/view/X00785 EMBL X82933 http://www.ebi.ac.uk/ena/data/view/X82933 ENZYME 2.7.4.25 http://enzyme.expasy.org/EC/2.7.4.25 EchoBASE EB1244 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1244 EcoGene EG11265 http://www.ecogene.org/geneInfo.php?eg_id=EG11265 EnsemblBacteria AAC73996 http://www.ensemblgenomes.org/id/AAC73996 EnsemblBacteria AAC73996 http://www.ensemblgenomes.org/id/AAC73996 EnsemblBacteria BAA35645 http://www.ensemblgenomes.org/id/BAA35645 EnsemblBacteria BAA35645 http://www.ensemblgenomes.org/id/BAA35645 EnsemblBacteria BAA35645 http://www.ensemblgenomes.org/id/BAA35645 EnsemblBacteria b0910 http://www.ensemblgenomes.org/id/b0910 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004127 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004127 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006220 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006220 GO_process GO:0015949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015949 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945535 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945535 HAMAP MF_00238 http://hamap.expasy.org/unirule/MF_00238 HOGENOM HOG000242849 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000242849&db=HOGENOM6 InParanoid P0A6I0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6I0 IntAct P0A6I0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6I0* IntEnz 2.7.4.25 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.4.25 InterPro IPR003136 http://www.ebi.ac.uk/interpro/entry/IPR003136 InterPro IPR011994 http://www.ebi.ac.uk/interpro/entry/IPR011994 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0893 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0893 KEGG_Gene eco:b0910 http://www.genome.jp/dbget-bin/www_bget?eco:b0910 KEGG_Orthology KO:K00945 http://www.genome.jp/dbget-bin/www_bget?KO:K00945 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Reaction rn:R00158 http://www.genome.jp/dbget-bin/www_bget?rn:R00158 KEGG_Reaction rn:R00512 http://www.genome.jp/dbget-bin/www_bget?rn:R00512 KEGG_Reaction rn:R01665 http://www.genome.jp/dbget-bin/www_bget?rn:R01665 OMA VRARRRY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VRARRRY PDB 1CKE http://www.ebi.ac.uk/pdbe-srv/view/entry/1CKE PDB 1KDO http://www.ebi.ac.uk/pdbe-srv/view/entry/1KDO PDB 1KDP http://www.ebi.ac.uk/pdbe-srv/view/entry/1KDP PDB 1KDR http://www.ebi.ac.uk/pdbe-srv/view/entry/1KDR PDB 1KDT http://www.ebi.ac.uk/pdbe-srv/view/entry/1KDT PDB 2CMK http://www.ebi.ac.uk/pdbe-srv/view/entry/2CMK PDB 2FEM http://www.ebi.ac.uk/pdbe-srv/view/entry/2FEM PDB 2FEO http://www.ebi.ac.uk/pdbe-srv/view/entry/2FEO PDBsum 1CKE http://www.ebi.ac.uk/pdbsum/1CKE PDBsum 1KDO http://www.ebi.ac.uk/pdbsum/1KDO PDBsum 1KDP http://www.ebi.ac.uk/pdbsum/1KDP PDBsum 1KDR http://www.ebi.ac.uk/pdbsum/1KDR PDBsum 1KDT http://www.ebi.ac.uk/pdbsum/1KDT PDBsum 2CMK http://www.ebi.ac.uk/pdbsum/2CMK PDBsum 2FEM http://www.ebi.ac.uk/pdbsum/2FEM PDBsum 2FEO http://www.ebi.ac.uk/pdbsum/2FEO PSORT swissprot:KCY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:KCY_ECOLI PSORT-B swissprot:KCY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:KCY_ECOLI PSORT2 swissprot:KCY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:KCY_ECOLI Pfam PF02224 http://pfam.xfam.org/family/PF02224 Phobius swissprot:KCY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:KCY_ECOLI PhylomeDB P0A6I0 http://phylomedb.org/?seqid=P0A6I0 ProteinModelPortal P0A6I0 http://www.proteinmodelportal.org/query/uniprot/P0A6I0 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6281725 http://www.ncbi.nlm.nih.gov/pubmed/6281725 PubMed 6384724 http://www.ncbi.nlm.nih.gov/pubmed/6384724 PubMed 7836281 http://www.ncbi.nlm.nih.gov/pubmed/7836281 PubMed 8190075 http://www.ncbi.nlm.nih.gov/pubmed/8190075 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9126287 http://www.ncbi.nlm.nih.gov/pubmed/9126287 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9862805 http://www.ncbi.nlm.nih.gov/pubmed/9862805 RefSeq NP_415430 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415430 RefSeq WP_000125016 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000125016 SMR P0A6I0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6I0 STRING 511145.b0910 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0910&targetmode=cogs STRING COG0283 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0283&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR00017 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00017 UniProtKB KCY_ECOLI http://www.uniprot.org/uniprot/KCY_ECOLI UniProtKB-AC P0A6I0 http://www.uniprot.org/uniprot/P0A6I0 charge swissprot:KCY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:KCY_ECOLI eggNOG COG0283 http://eggnogapi.embl.de/nog_data/html/tree/COG0283 eggNOG ENOG4105CAT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CAT epestfind swissprot:KCY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:KCY_ECOLI garnier swissprot:KCY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:KCY_ECOLI helixturnhelix swissprot:KCY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:KCY_ECOLI hmoment swissprot:KCY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:KCY_ECOLI iep swissprot:KCY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:KCY_ECOLI inforesidue swissprot:KCY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:KCY_ECOLI octanol swissprot:KCY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:KCY_ECOLI pepcoil swissprot:KCY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:KCY_ECOLI pepdigest swissprot:KCY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:KCY_ECOLI pepinfo swissprot:KCY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:KCY_ECOLI pepnet swissprot:KCY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:KCY_ECOLI pepstats swissprot:KCY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:KCY_ECOLI pepwheel swissprot:KCY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:KCY_ECOLI pepwindow swissprot:KCY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:KCY_ECOLI sigcleave swissprot:KCY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:KCY_ECOLI ## Database ID URL or Descriptions # BioGrid 4261421 115 # EcoGene EG10625 mutS # FUNCTION MUTS_ECOLI This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0032300 mismatch repair complex; IGI:EcoliWiki. # GO_function GO:0003684 damaged DNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0005524 ATP binding; IDA:EcoliWiki. # GO_function GO:0008301 DNA binding, bending; IDA:EcoliWiki. # GO_function GO:0016887 ATPase activity; IDA:EcoliWiki. # GO_function GO:0030983 mismatched DNA binding; IDA:EcoliWiki. # GO_function GO:0032136 adenine/cytosine mispair binding; IDA:EcoliWiki. # GO_function GO:0043531 ADP binding; IDA:EcoliWiki. # GO_process GO:0000018 regulation of DNA recombination; IMP:EcoliWiki. # GO_process GO:0006298 mismatch repair; IDA:EcoliWiki. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # Gene3D 3.30.420.110 -; 1. # Gene3D 3.40.1170.10 -; 1. # Gene3D 3.40.50.300 -; 1. # HAMAP MF_00096 MutS # INTERACTION MUTS_ECOLI Self; NbExp=3; IntAct=EBI-554920, EBI-554920; # IntAct P23909 10 # InterPro IPR000432 DNA_mismatch_repair_MutS_C # InterPro IPR005748 DNA_mismatch_repair_MutS-1 # InterPro IPR007695 DNA_mismatch_repair_MutS-lik_N # InterPro IPR007696 DNA_mismatch_repair_MutS_core # InterPro IPR007860 DNA_mmatch_repair_MutS_con_dom # InterPro IPR007861 DNA_mismatch_repair_MutS_clamp # InterPro IPR016151 DNA_mismatch_repair_MutS_N # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko03430 Mismatch repair # Organism MUTS_ECOLI Escherichia coli (strain K12) # PATRIC 32120868 VBIEscCol129921_2826 # PDB 1E3M X-ray; 2.20 A; A/B=1-800 # PDB 1NG9 X-ray; 2.60 A; A/B=1-800 # PDB 1OH5 X-ray; 2.90 A; A/B=1-800 # PDB 1OH6 X-ray; 2.40 A; A/B=1-800 # PDB 1OH7 X-ray; 2.50 A; A/B=1-800 # PDB 1OH8 X-ray; 2.90 A; A/B=1-800 # PDB 1W7A X-ray; 2.27 A; A/B=1-800 # PDB 1WB9 X-ray; 2.10 A; A/B=1-800 # PDB 1WBB X-ray; 2.50 A; A/B=1-800 # PDB 1WBD X-ray; 2.40 A; A/B=1-800 # PDB 2OK2 X-ray; 2.00 A; A/B=820-853 # PDB 2WTU X-ray; 3.40 A; A/B=1-800 # PDB 3K0S X-ray; 2.20 A; A/B=2-800 # PDB 3ZLJ X-ray; 3.10 A; A/B=1-800, C/D=801-853 # PDB 5AKB X-ray; 4.71 A; A/B/E=1-800 # PDB 5AKC X-ray; 6.60 A; A/B/E/F/I/J=1-800 # PDB 5AKD X-ray; 7.60 A; A/B/E/F/I/J=1-800 # PIR I54964 I54964 # PROSITE PS00486 DNA_MISMATCH_REPAIR_2 # Pfam PF00488 MutS_V # Pfam PF01624 MutS_I # Pfam PF05188 MutS_II # Pfam PF05190 MutS_IV # Pfam PF05192 MutS_III # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MUTS_ECOLI DNA mismatch repair protein MutS # RefSeq NP_417213 NC_000913.3 # RefSeq WP_001272928 NZ_LN832404.1 # SIMILARITY Belongs to the DNA mismatch repair MutS family. {ECO 0000305}. # SMART SM00533 MUTSd # SMART SM00534 MUTSac # SUPFAM SSF48334 SSF48334 # SUPFAM SSF52540 SSF52540 # SUPFAM SSF53150 SSF53150 # SUPFAM SSF55271 SSF55271 # TIGRFAMs TIGR01070 mutS1 # eggNOG COG0249 LUCA # eggNOG ENOG4105D86 Bacteria BLAST swissprot:MUTS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MUTS_ECOLI BioCyc ECOL316407:JW2703-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2703-MONOMER BioCyc EcoCyc:EG10625-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10625-MONOMER BioCyc MetaCyc:EG10625-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10625-MONOMER COG COG0249 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0249 DIP DIP-10287N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10287N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AF001987 http://www.ebi.ac.uk/ena/data/view/AF001987 EMBL AF001988 http://www.ebi.ac.uk/ena/data/view/AF001988 EMBL AF001989 http://www.ebi.ac.uk/ena/data/view/AF001989 EMBL AF001990 http://www.ebi.ac.uk/ena/data/view/AF001990 EMBL AF001991 http://www.ebi.ac.uk/ena/data/view/AF001991 EMBL AF001992 http://www.ebi.ac.uk/ena/data/view/AF001992 EMBL AF001993 http://www.ebi.ac.uk/ena/data/view/AF001993 EMBL AF001994 http://www.ebi.ac.uk/ena/data/view/AF001994 EMBL AF001995 http://www.ebi.ac.uk/ena/data/view/AF001995 EMBL AF001996 http://www.ebi.ac.uk/ena/data/view/AF001996 EMBL AF001997 http://www.ebi.ac.uk/ena/data/view/AF001997 EMBL AF001998 http://www.ebi.ac.uk/ena/data/view/AF001998 EMBL AF001999 http://www.ebi.ac.uk/ena/data/view/AF001999 EMBL AF002000 http://www.ebi.ac.uk/ena/data/view/AF002000 EMBL AF002001 http://www.ebi.ac.uk/ena/data/view/AF002001 EMBL AF002002 http://www.ebi.ac.uk/ena/data/view/AF002002 EMBL AF002003 http://www.ebi.ac.uk/ena/data/view/AF002003 EMBL AF002004 http://www.ebi.ac.uk/ena/data/view/AF002004 EMBL AF002005 http://www.ebi.ac.uk/ena/data/view/AF002005 EMBL AF002006 http://www.ebi.ac.uk/ena/data/view/AF002006 EMBL AF002007 http://www.ebi.ac.uk/ena/data/view/AF002007 EMBL AF002008 http://www.ebi.ac.uk/ena/data/view/AF002008 EMBL AF002009 http://www.ebi.ac.uk/ena/data/view/AF002009 EMBL AF002010 http://www.ebi.ac.uk/ena/data/view/AF002010 EMBL AF004287 http://www.ebi.ac.uk/ena/data/view/AF004287 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M64730 http://www.ebi.ac.uk/ena/data/view/M64730 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EchoBASE EB0620 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0620 EcoGene EG10625 http://www.ecogene.org/geneInfo.php?eg_id=EG10625 EnsemblBacteria AAC75775 http://www.ensemblgenomes.org/id/AAC75775 EnsemblBacteria AAC75775 http://www.ensemblgenomes.org/id/AAC75775 EnsemblBacteria BAE76810 http://www.ensemblgenomes.org/id/BAE76810 EnsemblBacteria BAE76810 http://www.ensemblgenomes.org/id/BAE76810 EnsemblBacteria BAE76810 http://www.ensemblgenomes.org/id/BAE76810 EnsemblBacteria b2733 http://www.ensemblgenomes.org/id/b2733 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0032300 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032300 GO_function GO:0003684 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003684 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008301 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_function GO:0030983 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030983 GO_function GO:0032136 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032136 GO_function GO:0043531 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043531 GO_process GO:0000018 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000018 GO_process GO:0006298 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006298 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.30.420.110 http://www.cathdb.info/version/latest/superfamily/3.30.420.110 Gene3D 3.40.1170.10 http://www.cathdb.info/version/latest/superfamily/3.40.1170.10 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947206 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947206 HAMAP MF_00096 http://hamap.expasy.org/unirule/MF_00096 HOGENOM HOG000221407 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000221407&db=HOGENOM6 InParanoid P23909 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23909 IntAct P23909 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P23909* InterPro IPR000432 http://www.ebi.ac.uk/interpro/entry/IPR000432 InterPro IPR005748 http://www.ebi.ac.uk/interpro/entry/IPR005748 InterPro IPR007695 http://www.ebi.ac.uk/interpro/entry/IPR007695 InterPro IPR007696 http://www.ebi.ac.uk/interpro/entry/IPR007696 InterPro IPR007860 http://www.ebi.ac.uk/interpro/entry/IPR007860 InterPro IPR007861 http://www.ebi.ac.uk/interpro/entry/IPR007861 InterPro IPR016151 http://www.ebi.ac.uk/interpro/entry/IPR016151 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW2703 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2703 KEGG_Gene eco:b2733 http://www.genome.jp/dbget-bin/www_bget?eco:b2733 KEGG_Orthology KO:K03555 http://www.genome.jp/dbget-bin/www_bget?KO:K03555 KEGG_Pathway ko03430 http://www.genome.jp/kegg-bin/show_pathway?ko03430 MINT MINT-1264156 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1264156 OMA EMTEMAN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EMTEMAN PDB 1E3M http://www.ebi.ac.uk/pdbe-srv/view/entry/1E3M PDB 1NG9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1NG9 PDB 1OH5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1OH5 PDB 1OH6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1OH6 PDB 1OH7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1OH7 PDB 1OH8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1OH8 PDB 1W7A http://www.ebi.ac.uk/pdbe-srv/view/entry/1W7A PDB 1WB9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1WB9 PDB 1WBB http://www.ebi.ac.uk/pdbe-srv/view/entry/1WBB PDB 1WBD http://www.ebi.ac.uk/pdbe-srv/view/entry/1WBD PDB 2OK2 http://www.ebi.ac.uk/pdbe-srv/view/entry/2OK2 PDB 2WTU http://www.ebi.ac.uk/pdbe-srv/view/entry/2WTU PDB 3K0S http://www.ebi.ac.uk/pdbe-srv/view/entry/3K0S PDB 3ZLJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZLJ PDB 5AKB http://www.ebi.ac.uk/pdbe-srv/view/entry/5AKB PDB 5AKC http://www.ebi.ac.uk/pdbe-srv/view/entry/5AKC PDB 5AKD http://www.ebi.ac.uk/pdbe-srv/view/entry/5AKD PDBsum 1E3M http://www.ebi.ac.uk/pdbsum/1E3M PDBsum 1NG9 http://www.ebi.ac.uk/pdbsum/1NG9 PDBsum 1OH5 http://www.ebi.ac.uk/pdbsum/1OH5 PDBsum 1OH6 http://www.ebi.ac.uk/pdbsum/1OH6 PDBsum 1OH7 http://www.ebi.ac.uk/pdbsum/1OH7 PDBsum 1OH8 http://www.ebi.ac.uk/pdbsum/1OH8 PDBsum 1W7A http://www.ebi.ac.uk/pdbsum/1W7A PDBsum 1WB9 http://www.ebi.ac.uk/pdbsum/1WB9 PDBsum 1WBB http://www.ebi.ac.uk/pdbsum/1WBB PDBsum 1WBD http://www.ebi.ac.uk/pdbsum/1WBD PDBsum 2OK2 http://www.ebi.ac.uk/pdbsum/2OK2 PDBsum 2WTU http://www.ebi.ac.uk/pdbsum/2WTU PDBsum 3K0S http://www.ebi.ac.uk/pdbsum/3K0S PDBsum 3ZLJ http://www.ebi.ac.uk/pdbsum/3ZLJ PDBsum 5AKB http://www.ebi.ac.uk/pdbsum/5AKB PDBsum 5AKC http://www.ebi.ac.uk/pdbsum/5AKC PDBsum 5AKD http://www.ebi.ac.uk/pdbsum/5AKD PROSITE PS00486 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00486 PSORT swissprot:MUTS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MUTS_ECOLI PSORT-B swissprot:MUTS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MUTS_ECOLI PSORT2 swissprot:MUTS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MUTS_ECOLI Pfam PF00488 http://pfam.xfam.org/family/PF00488 Pfam PF01624 http://pfam.xfam.org/family/PF01624 Pfam PF05188 http://pfam.xfam.org/family/PF05188 Pfam PF05190 http://pfam.xfam.org/family/PF05190 Pfam PF05192 http://pfam.xfam.org/family/PF05192 Phobius swissprot:MUTS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MUTS_ECOLI PhylomeDB P23909 http://phylomedb.org/?seqid=P23909 ProteinModelPortal P23909 http://www.proteinmodelportal.org/query/uniprot/P23909 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1938937 http://www.ncbi.nlm.nih.gov/pubmed/1938937 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417213 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417213 RefSeq WP_001272928 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001272928 SMART SM00533 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00533 SMART SM00534 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00534 SMR P23909 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P23909 STRING 511145.b2733 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2733&targetmode=cogs STRING COG0249 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0249&targetmode=cogs SUPFAM SSF48334 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48334 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SUPFAM SSF53150 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53150 SUPFAM SSF55271 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55271 SWISS-2DPAGE P23909 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P23909 TIGRFAMs TIGR01070 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01070 UniProtKB MUTS_ECOLI http://www.uniprot.org/uniprot/MUTS_ECOLI UniProtKB-AC P23909 http://www.uniprot.org/uniprot/P23909 charge swissprot:MUTS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MUTS_ECOLI eggNOG COG0249 http://eggnogapi.embl.de/nog_data/html/tree/COG0249 eggNOG ENOG4105D86 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D86 epestfind swissprot:MUTS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MUTS_ECOLI garnier swissprot:MUTS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MUTS_ECOLI helixturnhelix swissprot:MUTS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MUTS_ECOLI hmoment swissprot:MUTS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MUTS_ECOLI iep swissprot:MUTS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MUTS_ECOLI inforesidue swissprot:MUTS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MUTS_ECOLI octanol swissprot:MUTS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MUTS_ECOLI pepcoil swissprot:MUTS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MUTS_ECOLI pepdigest swissprot:MUTS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MUTS_ECOLI pepinfo swissprot:MUTS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MUTS_ECOLI pepnet swissprot:MUTS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MUTS_ECOLI pepstats swissprot:MUTS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MUTS_ECOLI pepwheel swissprot:MUTS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MUTS_ECOLI pepwindow swissprot:MUTS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MUTS_ECOLI sigcleave swissprot:MUTS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MUTS_ECOLI ## Database ID URL or Descriptions # BioGrid 4262878 127 # EcoGene EG14298 ynbE # InterPro IPR025985 YnbE-like # Organism YNBE_ECOLI Escherichia coli (strain K12) # PATRIC 32118050 VBIEscCol129921_1445 # PIR A64889 A64889 # Pfam PF13617 Lipoprotein_19 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNBE_ECOLI Uncharacterized protein YnbE # RefSeq NP_415900 NC_000913.3 # RefSeq WP_000698145 NZ_LN832404.1 # eggNOG ENOG410689M Bacteria # eggNOG ENOG410XVQC LUCA BLAST swissprot:YNBE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNBE_ECOLI BioCyc ECOL316407:JW1377-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1377-MONOMER BioCyc EcoCyc:G6704-MONOMER http://biocyc.org/getid?id=EcoCyc:G6704-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4045 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4045 EcoGene EG14298 http://www.ecogene.org/geneInfo.php?eg_id=EG14298 EnsemblBacteria AAC74464 http://www.ensemblgenomes.org/id/AAC74464 EnsemblBacteria AAC74464 http://www.ensemblgenomes.org/id/AAC74464 EnsemblBacteria BAE76420 http://www.ensemblgenomes.org/id/BAE76420 EnsemblBacteria BAE76420 http://www.ensemblgenomes.org/id/BAE76420 EnsemblBacteria BAE76420 http://www.ensemblgenomes.org/id/BAE76420 EnsemblBacteria b1382 http://www.ensemblgenomes.org/id/b1382 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945946 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945946 HOGENOM HOG000291235 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000291235&db=HOGENOM6 InParanoid P64448 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P64448 InterPro IPR025985 http://www.ebi.ac.uk/interpro/entry/IPR025985 KEGG_Gene ecj:JW1377 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1377 KEGG_Gene eco:b1382 http://www.genome.jp/dbget-bin/www_bget?eco:b1382 OMA GIFMLSG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GIFMLSG PSORT swissprot:YNBE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNBE_ECOLI PSORT-B swissprot:YNBE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNBE_ECOLI PSORT2 swissprot:YNBE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNBE_ECOLI Pfam PF13617 http://pfam.xfam.org/family/PF13617 Phobius swissprot:YNBE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNBE_ECOLI ProteinModelPortal P64448 http://www.proteinmodelportal.org/query/uniprot/P64448 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415900 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415900 RefSeq WP_000698145 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000698145 STRING 511145.b1382 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1382&targetmode=cogs UniProtKB YNBE_ECOLI http://www.uniprot.org/uniprot/YNBE_ECOLI UniProtKB-AC P64448 http://www.uniprot.org/uniprot/P64448 charge swissprot:YNBE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNBE_ECOLI eggNOG ENOG410689M http://eggnogapi.embl.de/nog_data/html/tree/ENOG410689M eggNOG ENOG410XVQC http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XVQC epestfind swissprot:YNBE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNBE_ECOLI garnier swissprot:YNBE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNBE_ECOLI helixturnhelix swissprot:YNBE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNBE_ECOLI hmoment swissprot:YNBE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNBE_ECOLI iep swissprot:YNBE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNBE_ECOLI inforesidue swissprot:YNBE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNBE_ECOLI octanol swissprot:YNBE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNBE_ECOLI pepcoil swissprot:YNBE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNBE_ECOLI pepdigest swissprot:YNBE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNBE_ECOLI pepinfo swissprot:YNBE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNBE_ECOLI pepnet swissprot:YNBE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNBE_ECOLI pepstats swissprot:YNBE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNBE_ECOLI pepwheel swissprot:YNBE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNBE_ECOLI pepwindow swissprot:YNBE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNBE_ECOLI sigcleave swissprot:YNBE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNBE_ECOLI ## Database ID URL or Descriptions # AltName DACD_ECOLI Penicillin-binding protein 6b # BioGrid 4260413 257 # CATALYTIC ACTIVITY Preferential cleavage (Ac)(2)-L-Lys-D-Ala-|- D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine. # EcoGene EG11893 dacD # FUNCTION DACD_ECOLI Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0004175 endopeptidase activity; IBA:GO_Central. # GO_function GO:0004180 carboxypeptidase activity; IMP:EcoCyc. # GO_function GO:0008658 penicillin binding; IDA:EcoCyc. # GO_function GO:0009002 serine-type D-Ala-D-Ala carboxypeptidase activity; IBA:GO_Central. # GO_process GO:0008360 regulation of cell shape; IGI:EcoCyc. # GO_process GO:0009252 peptidoglycan biosynthetic process; IMP:EcoCyc. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 2.60.410.10 -; 1. # Gene3D 3.40.710.10 -; 1. # InterPro IPR001967 Peptidase_S11_N # InterPro IPR012338 Beta-lactam/transpept-like # InterPro IPR012907 Peptidase_S11_C # InterPro IPR015956 Peniciliin-bd_prot-assoc # InterPro IPR018044 Peptidase_S11 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # KEGG_Pathway ko00550 Peptidoglycan biosynthesis # Organism DACD_ECOLI Escherichia coli (strain K12) # PATHWAY DACD_ECOLI Cell wall biogenesis; peptidoglycan biosynthesis. # PATRIC 32119355 VBIEscCol129921_2087 # PDB 5FSR X-ray; 2.40 A; A/B=22-374 # PIR A64966 A64966 # PRINTS PR00725 DADACBPTASE1 # Pfam PF00768 Peptidase_S11 # Pfam PF07943 PBP5_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DACD_ECOLI D-alanyl-D-alanine carboxypeptidase DacD # RefSeq NP_416514 NC_000913.3 # RefSeq WP_000830156 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA16416.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the peptidase S11 family. {ECO 0000305}. # SMART SM00936 PBP5_C # SUBCELLULAR LOCATION DACD_ECOLI Cell inner membrane {ECO 0000305}; Peripheral membrane protein {ECO 0000305}. Note=N-terminal lies in the periplasmic space. {ECO 0000305}. # SUPFAM SSF56601 SSF56601 # SUPFAM SSF69189 SSF69189 # eggNOG COG1686 LUCA # eggNOG ENOG4105DZ1 Bacteria BLAST swissprot:DACD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DACD_ECOLI BioCyc ECOL316407:JW5329-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5329-MONOMER BioCyc EcoCyc:RPOA-MONOMER http://biocyc.org/getid?id=EcoCyc:RPOA-MONOMER BioCyc MetaCyc:RPOA-MONOMER http://biocyc.org/getid?id=MetaCyc:RPOA-MONOMER COG COG1686 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1686 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.16.4 http://www.genome.jp/dbget-bin/www_bget?EC:3.4.16.4 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00009 http://www.ebi.ac.uk/ena/data/view/U00009 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.4.16.4 http://enzyme.expasy.org/EC/3.4.16.4 EchoBASE EB1839 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1839 EcoGene EG11893 http://www.ecogene.org/geneInfo.php?eg_id=EG11893 EnsemblBacteria AAC75071 http://www.ensemblgenomes.org/id/AAC75071 EnsemblBacteria AAC75071 http://www.ensemblgenomes.org/id/AAC75071 EnsemblBacteria BAA15838 http://www.ensemblgenomes.org/id/BAA15838 EnsemblBacteria BAA15838 http://www.ensemblgenomes.org/id/BAA15838 EnsemblBacteria BAA15838 http://www.ensemblgenomes.org/id/BAA15838 EnsemblBacteria b2010 http://www.ensemblgenomes.org/id/b2010 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0004175 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004175 GO_function GO:0004180 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004180 GO_function GO:0008658 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008658 GO_function GO:0009002 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009002 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0009252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009252 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 2.60.410.10 http://www.cathdb.info/version/latest/superfamily/2.60.410.10 Gene3D 3.40.710.10 http://www.cathdb.info/version/latest/superfamily/3.40.710.10 GeneID 946518 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946518 HOGENOM HOG000086623 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000086623&db=HOGENOM6 InParanoid P33013 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33013 IntEnz 3.4.16.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.16.4 InterPro IPR001967 http://www.ebi.ac.uk/interpro/entry/IPR001967 InterPro IPR012338 http://www.ebi.ac.uk/interpro/entry/IPR012338 InterPro IPR012907 http://www.ebi.ac.uk/interpro/entry/IPR012907 InterPro IPR015956 http://www.ebi.ac.uk/interpro/entry/IPR015956 InterPro IPR018044 http://www.ebi.ac.uk/interpro/entry/IPR018044 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW5329 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5329 KEGG_Gene eco:b2010 http://www.genome.jp/dbget-bin/www_bget?eco:b2010 KEGG_Orthology KO:K07258 http://www.genome.jp/dbget-bin/www_bget?KO:K07258 KEGG_Pathway ko00550 http://www.genome.jp/kegg-bin/show_pathway?ko00550 OMA TNTHFET http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TNTHFET PDB 5FSR http://www.ebi.ac.uk/pdbe-srv/view/entry/5FSR PDBsum 5FSR http://www.ebi.ac.uk/pdbsum/5FSR PRINTS PR00725 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00725 PSORT swissprot:DACD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DACD_ECOLI PSORT-B swissprot:DACD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DACD_ECOLI PSORT2 swissprot:DACD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DACD_ECOLI Pfam PF00768 http://pfam.xfam.org/family/PF00768 Pfam PF07943 http://pfam.xfam.org/family/PF07943 Phobius swissprot:DACD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DACD_ECOLI PhylomeDB P33013 http://phylomedb.org/?seqid=P33013 ProteinModelPortal P33013 http://www.proteinmodelportal.org/query/uniprot/P33013 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8955390 http://www.ncbi.nlm.nih.gov/pubmed/8955390 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416514 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416514 RefSeq WP_000830156 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000830156 SMART SM00936 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00936 SMR P33013 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33013 STRING 511145.b2010 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2010&targetmode=cogs STRING COG1686 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1686&targetmode=cogs SUPFAM SSF56601 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56601 SUPFAM SSF69189 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF69189 UniProtKB DACD_ECOLI http://www.uniprot.org/uniprot/DACD_ECOLI UniProtKB-AC P33013 http://www.uniprot.org/uniprot/P33013 charge swissprot:DACD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DACD_ECOLI eggNOG COG1686 http://eggnogapi.embl.de/nog_data/html/tree/COG1686 eggNOG ENOG4105DZ1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DZ1 epestfind swissprot:DACD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DACD_ECOLI garnier swissprot:DACD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DACD_ECOLI helixturnhelix swissprot:DACD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DACD_ECOLI hmoment swissprot:DACD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DACD_ECOLI iep swissprot:DACD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DACD_ECOLI inforesidue swissprot:DACD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DACD_ECOLI octanol swissprot:DACD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DACD_ECOLI pepcoil swissprot:DACD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DACD_ECOLI pepdigest swissprot:DACD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DACD_ECOLI pepinfo swissprot:DACD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DACD_ECOLI pepnet swissprot:DACD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DACD_ECOLI pepstats swissprot:DACD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DACD_ECOLI pepwheel swissprot:DACD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DACD_ECOLI pepwindow swissprot:DACD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DACD_ECOLI sigcleave swissprot:DACD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DACD_ECOLI ## Database ID URL or Descriptions # BioGrid 4259511 234 # DISRUPTION PHENOTYPE SECE_ECOLI Essential; deletion experiments lead to loss of the SecYEG tranlocation channel. Leads to loss of translocation of lipoproteins Lpp and BRP (PubMed 15140892) and accumulation of signal peptidase I (lepB) in a soluble fraction (PubMed 21778229). {ECO 0000269|PubMed 15140892, ECO 0000269|PubMed 21778229}. # EcoGene EG10939 secE # FUNCTION SECE_ECOLI Essential subunit of the protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. Overexpression of some hybrid proteins has been thought to jam the protein secretion apparatus resulting in cell death; while this may be true it also results in FtsH-mediated degradation of SecY. {ECO 0000269|PubMed 15140892}. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IDA:EcoliWiki. # GO_component GO:0031522 cell envelope Sec protein transport complex; IDA:EcoCyc. # GO_function GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity; IEA:InterPro. # GO_process GO:0006605 protein targeting; IEA:UniProtKB-HAMAP. # GO_process GO:0006886 intracellular protein transport; IMP:EcoliWiki. # GO_process GO:0009306 protein secretion; IEA:UniProtKB-HAMAP. # GO_process GO:0043952 protein transport by the Sec complex; IMP:EcoliWiki. # GO_process GO:0065002 intracellular protein transmembrane transport; IMP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005622 intracellular # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0008565 protein transporter activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006605 protein targeting # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # HAMAP MF_00422 SecE # IntAct P0AG96 2 # InterPro IPR001901 Translocase_SecE/Sec61-g # InterPro IPR005807 SecE_bac # InterPro IPR022943 SecE # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02044 M00335 Sec (secretion) system # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko03060 Protein export # KEGG_Pathway ko03070 Bacterial secretion system # Organism SECE_ECOLI Escherichia coli (strain K12) # PATRIC 32123483 VBIEscCol129921_4094 # PDB 2AKH EM; 14.90 A; C/Z=17-127 # PDB 2AKI EM; 14.90 A; C/Z=17-127 # PDB 3J45 EM; 9.50 A; E=74-127 # PDB 3J46 EM; 10.10 A; E=74-127 # PDB 4V6M EM; -; B=12-127 # PDB 5GAE EM; 3.33 A; h=1-127 # PIR A35139 VXECSE # PRINTS PR01650 SECETRNLCASE # PROSITE PS01067 SECE_SEC61G # PTM SECE_ECOLI Degraded by FtsH when the SecYEG complex is jammed or upon treatment with antibiotics that block translation elongation such as chloramphenicol. # Pfam PF00584 SecE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Protein translocase subunit SecE {ECO:0000255|HAMAP-Rule MF_00422} # RefSeq NP_418408 NC_000913.3 # RefSeq WP_001275702 NZ_LN832404.1 # SIMILARITY Belongs to the SecE/SEC61-gamma family. {ECO:0000255|HAMAP-Rule MF_00422}. # SUBCELLULAR LOCATION SECE_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_00422, ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255|HAMAP-Rule MF_00422, ECO 0000269|PubMed 15919996}. # SUBUNIT SECE_ECOLI Part of the essential Sec protein translocation complex which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC/OxaA. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. The channel interacts with SecA via subunit SecY. SecE might contact ribosomal protein L23 and/or L29 when the translocation complex is docked with the ribosome. {ECO 0000269|PubMed 10698927, ECO 0000269|PubMed 10944122}. # TCDB 3.A.5.1 the general secretory pathway (sec) family # TIGRFAMs TIGR00964 secE_bact # eggNOG COG0690 LUCA # eggNOG ENOG4105PM1 Bacteria BLAST swissprot:SECE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SECE_ECOLI BioCyc ECOL316407:JW3944-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3944-MONOMER BioCyc EcoCyc:SECE http://biocyc.org/getid?id=EcoCyc:SECE COG COG0690 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0690 DIP DIP-59303N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-59303N DOI 10.1016/j.molcel.2007.03.022 http://dx.doi.org/10.1016/j.molcel.2007.03.022 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature04133 http://dx.doi.org/10.1038/nature04133 DOI 10.1038/nsmb.2026 http://dx.doi.org/10.1038/nsmb.2026 DOI 10.1074/jbc.M111.245696 http://dx.doi.org/10.1074/jbc.M111.245696 DOI 10.1074/jbc.M403229200 http://dx.doi.org/10.1074/jbc.M403229200 DOI 10.1093/emboj/19.16.4393 http://dx.doi.org/10.1093/emboj/19.16.4393 DOI 10.1093/emboj/19.5.852 http://dx.doi.org/10.1093/emboj/19.5.852 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1101/gad.3.7.1035 http://dx.doi.org/10.1101/gad.3.7.1035 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.1172221 http://dx.doi.org/10.1126/science.1172221 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1146/annurev.biochem.77.061606.160747 http://dx.doi.org/10.1146/annurev.biochem.77.061606.160747 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M30610 http://www.ebi.ac.uk/ena/data/view/M30610 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0932 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0932 EcoGene EG10939 http://www.ecogene.org/geneInfo.php?eg_id=EG10939 EnsemblBacteria AAC76955 http://www.ensemblgenomes.org/id/AAC76955 EnsemblBacteria AAC76955 http://www.ensemblgenomes.org/id/AAC76955 EnsemblBacteria BAE77339 http://www.ensemblgenomes.org/id/BAE77339 EnsemblBacteria BAE77339 http://www.ensemblgenomes.org/id/BAE77339 EnsemblBacteria BAE77339 http://www.ensemblgenomes.org/id/BAE77339 EnsemblBacteria b3981 http://www.ensemblgenomes.org/id/b3981 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0031522 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031522 GO_function GO:0015450 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015450 GO_process GO:0006605 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006605 GO_process GO:0006886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006886 GO_process GO:0009306 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009306 GO_process GO:0043952 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043952 GO_process GO:0065002 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0065002 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006605 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006605 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 948486 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948486 HAMAP MF_00422 http://hamap.expasy.org/unirule/MF_00422 HOGENOM HOG000219148 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219148&db=HOGENOM6 InParanoid P0AG96 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AG96 IntAct P0AG96 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AG96* InterPro IPR001901 http://www.ebi.ac.uk/interpro/entry/IPR001901 InterPro IPR005807 http://www.ebi.ac.uk/interpro/entry/IPR005807 InterPro IPR022943 http://www.ebi.ac.uk/interpro/entry/IPR022943 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW3944 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3944 KEGG_Gene eco:b3981 http://www.genome.jp/dbget-bin/www_bget?eco:b3981 KEGG_Orthology KO:K03073 http://www.genome.jp/dbget-bin/www_bget?KO:K03073 KEGG_Pathway ko03060 http://www.genome.jp/kegg-bin/show_pathway?ko03060 KEGG_Pathway ko03070 http://www.genome.jp/kegg-bin/show_pathway?ko03070 OMA TRPEATQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TRPEATQ PDB 2AKH http://www.ebi.ac.uk/pdbe-srv/view/entry/2AKH PDB 2AKI http://www.ebi.ac.uk/pdbe-srv/view/entry/2AKI PDB 3J45 http://www.ebi.ac.uk/pdbe-srv/view/entry/3J45 PDB 3J46 http://www.ebi.ac.uk/pdbe-srv/view/entry/3J46 PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 5GAE http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAE PDBsum 2AKH http://www.ebi.ac.uk/pdbsum/2AKH PDBsum 2AKI http://www.ebi.ac.uk/pdbsum/2AKI PDBsum 3J45 http://www.ebi.ac.uk/pdbsum/3J45 PDBsum 3J46 http://www.ebi.ac.uk/pdbsum/3J46 PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 5GAE http://www.ebi.ac.uk/pdbsum/5GAE PRINTS PR01650 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01650 PROSITE PS01067 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01067 PSORT swissprot:SECE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SECE_ECOLI PSORT-B swissprot:SECE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SECE_ECOLI PSORT2 swissprot:SECE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SECE_ECOLI Pfam PF00584 http://pfam.xfam.org/family/PF00584 Phobius swissprot:SECE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SECE_ECOLI ProteinModelPortal P0AG96 http://www.proteinmodelportal.org/query/uniprot/P0AG96 PubMed 10698927 http://www.ncbi.nlm.nih.gov/pubmed/10698927 PubMed 10944122 http://www.ncbi.nlm.nih.gov/pubmed/10944122 PubMed 15140892 http://www.ncbi.nlm.nih.gov/pubmed/15140892 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16292303 http://www.ncbi.nlm.nih.gov/pubmed/16292303 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17531809 http://www.ncbi.nlm.nih.gov/pubmed/17531809 PubMed 18078384 http://www.ncbi.nlm.nih.gov/pubmed/18078384 PubMed 19661432 http://www.ncbi.nlm.nih.gov/pubmed/19661432 PubMed 2050112 http://www.ncbi.nlm.nih.gov/pubmed/2050112 PubMed 2137819 http://www.ncbi.nlm.nih.gov/pubmed/2137819 PubMed 21499241 http://www.ncbi.nlm.nih.gov/pubmed/21499241 PubMed 21778229 http://www.ncbi.nlm.nih.gov/pubmed/21778229 PubMed 2673920 http://www.ncbi.nlm.nih.gov/pubmed/2673920 PubMed 7889938 http://www.ncbi.nlm.nih.gov/pubmed/7889938 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418408 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418408 RefSeq WP_001275702 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001275702 SMR P0AG96 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AG96 STRING 511145.b3981 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3981&targetmode=cogs STRING COG0690 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0690&targetmode=cogs TCDB 3.A.5.1 http://www.tcdb.org/search/result.php?tc=3.A.5.1 TIGRFAMs TIGR00964 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00964 UniProtKB SECE_ECOLI http://www.uniprot.org/uniprot/SECE_ECOLI UniProtKB-AC P0AG96 http://www.uniprot.org/uniprot/P0AG96 charge swissprot:SECE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SECE_ECOLI eggNOG COG0690 http://eggnogapi.embl.de/nog_data/html/tree/COG0690 eggNOG ENOG4105PM1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105PM1 epestfind swissprot:SECE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SECE_ECOLI garnier swissprot:SECE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SECE_ECOLI helixturnhelix swissprot:SECE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SECE_ECOLI hmoment swissprot:SECE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SECE_ECOLI iep swissprot:SECE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SECE_ECOLI inforesidue swissprot:SECE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SECE_ECOLI octanol swissprot:SECE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SECE_ECOLI pepcoil swissprot:SECE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SECE_ECOLI pepdigest swissprot:SECE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SECE_ECOLI pepinfo swissprot:SECE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SECE_ECOLI pepnet swissprot:SECE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SECE_ECOLI pepstats swissprot:SECE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SECE_ECOLI pepwheel swissprot:SECE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SECE_ECOLI pepwindow swissprot:SECE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SECE_ECOLI sigcleave swissprot:SECE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SECE_ECOLI ## Database ID URL or Descriptions # AltName HLDE_ECOLI D-beta-D-heptose 7-phosphotransferase # AltName HLDE_ECOLI D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase # AltName HLDE_ECOLI D-glycero-beta-D-manno-heptose-7-phosphate kinase # AltName HLDE_ECOLI D-glycero-beta-D-manno-heptose-7-phosphate kinase # BRENDA 2.7.1.167 2026 # BRENDA 2.7.7.70 2026 # BioGrid 4261504 425 # CATALYTIC ACTIVITY D-glycero-beta-D-manno-heptose 1-phosphate + ATP = ADP-D-glycero-beta-D-manno-heptose + diphosphate. {ECO:0000269|PubMed 11751812}. # CATALYTIC ACTIVITY D-glycero-beta-D-manno-heptose 7-phosphate + ATP = D-glycero-beta-D-manno-heptose 1,7-bisphosphate + ADP. {ECO:0000269|PubMed 11751812}. # CDD cd01172 RfaE_like # EcoGene EG13416 hldE # FUNCTION HLDE_ECOLI Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose. {ECO 0000269|PubMed 11751812}. # FUNCTION HLDE_ECOLI Catalyzes the phosphorylation of D-glycero-D-manno- heptose 7-phosphate at the C-1 position to selectively form D- glycero-beta-D-manno-heptose-1,7-bisphosphate. {ECO 0000269|PubMed 11751812}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0016773 phosphotransferase activity, alcohol group as acceptor; IEA:InterPro. # GO_function GO:0033785 heptose 7-phosphate kinase activity; IDA:EcoCyc. # GO_function GO:0033786 heptose-1-phosphate adenylyltransferase activity; IDA:EcoCyc. # GO_process GO:0009244 lipopolysaccharide core region biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0097171 ADP-L-glycero-beta-D-manno-heptose biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.1190.20 -; 1. # Gene3D 3.40.50.620 -; 1. # HAMAP MF_01603 HldE # InterPro IPR002173 Carboh/pur_kinase_PfkB_CS # InterPro IPR004821 Cyt_trans-like # InterPro IPR011611 PfkB_dom # InterPro IPR011913 RfaE_dom_I # InterPro IPR011914 RfaE_dom_II # InterPro IPR014729 Rossmann-like_a/b/a_fold # InterPro IPR023030 Bifunc_HldE # InterPro IPR029056 Ribokinase-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # KEGG_Pathway ko00540 Lipopolysaccharide biosynthesis # MISCELLANEOUS HLDE_ECOLI In both reactions the enzyme functions only with beta anomers. # MISCELLANEOUS HLDE_ECOLI The function of the domain II is independent from the activity mediated by domain I. # Organism HLDE_ECOLI Escherichia coli (strain K12) # PATHWAY HLDE_ECOLI Bacterial outer membrane biogenesis; LPS core biosynthesis. # PATHWAY Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D- manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate step 1/4. # PATHWAY Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D- manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate step 3/4. # PATRIC 32121516 VBIEscCol129921_3145 # PIR B65093 B65093 # PROSITE PS00583 PFKB_KINASES_1 # Pfam PF00294 PfkB # Pfam PF01467 CTP_transf_like # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HLDE_ECOLI Bifunctional protein HldE # RecName HLDE_ECOLI Bifunctional protein HldE # RecName HLDE_ECOLI D-beta-D-heptose 1-phosphate adenylyltransferase # RecName HLDE_ECOLI D-beta-D-heptose 7-phosphate kinase # RefSeq NP_417524 NC_000913.3 # RefSeq WP_000869178 NZ_LN832404.1 # SIMILARITY In the C-terminal section; belongs to the cytidylyltransferase family. {ECO 0000305}. # SIMILARITY In the N-terminal section; belongs to the carbohydrate kinase PfkB family. {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 16030223}. # SUPFAM SSF53613 SSF53613 # TIGRFAMs TIGR00125 cyt_tran_rel # TIGRFAMs TIGR02198 rfaE_dom_I # TIGRFAMs TIGR02199 rfaE_dom_II # UniPathway UPA00356 UER00437 # UniPathway UPA00356 UER00439 # eggNOG COG2870 LUCA # eggNOG ENOG4105DW0 Bacteria BLAST swissprot:HLDE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HLDE_ECOLI BioCyc ECOL316407:JW3024-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3024-MONOMER BioCyc EcoCyc:G7590-MONOMER http://biocyc.org/getid?id=EcoCyc:G7590-MONOMER BioCyc MetaCyc:G7590-MONOMER http://biocyc.org/getid?id=MetaCyc:G7590-MONOMER COG COG2870 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2870 DIP DIP-10666N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10666N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.2.488-497.2000 http://dx.doi.org/10.1128/JB.182.2.488-497.2000 DOI 10.1128/JB.184.2.363-369.2002 http://dx.doi.org/10.1128/JB.184.2.363-369.2002 DOI 10.1128/JB.187.15.5292-5300.2005 http://dx.doi.org/10.1128/JB.187.15.5292-5300.2005 EC_number EC:2.7.1.167 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.167 EC_number EC:2.7.7.70 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.70 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL AY605712 http://www.ebi.ac.uk/ena/data/view/AY605712 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.167 http://enzyme.expasy.org/EC/2.7.1.167 ENZYME 2.7.7.70 http://enzyme.expasy.org/EC/2.7.7.70 EchoBASE EB3192 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3192 EcoGene EG13416 http://www.ecogene.org/geneInfo.php?eg_id=EG13416 EnsemblBacteria AAC76088 http://www.ensemblgenomes.org/id/AAC76088 EnsemblBacteria AAC76088 http://www.ensemblgenomes.org/id/AAC76088 EnsemblBacteria BAE77103 http://www.ensemblgenomes.org/id/BAE77103 EnsemblBacteria BAE77103 http://www.ensemblgenomes.org/id/BAE77103 EnsemblBacteria BAE77103 http://www.ensemblgenomes.org/id/BAE77103 EnsemblBacteria b3052 http://www.ensemblgenomes.org/id/b3052 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016773 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016773 GO_function GO:0033785 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033785 GO_function GO:0033786 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033786 GO_process GO:0009244 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009244 GO_process GO:0097171 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097171 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.1190.20 http://www.cathdb.info/version/latest/superfamily/3.40.1190.20 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 GeneID 947548 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947548 HAMAP MF_01603 http://hamap.expasy.org/unirule/MF_01603 HOGENOM HOG000237584 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000237584&db=HOGENOM6 InParanoid P76658 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76658 IntEnz 2.7.1.167 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.167 IntEnz 2.7.7.70 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.70 InterPro IPR002173 http://www.ebi.ac.uk/interpro/entry/IPR002173 InterPro IPR004821 http://www.ebi.ac.uk/interpro/entry/IPR004821 InterPro IPR011611 http://www.ebi.ac.uk/interpro/entry/IPR011611 InterPro IPR011913 http://www.ebi.ac.uk/interpro/entry/IPR011913 InterPro IPR011914 http://www.ebi.ac.uk/interpro/entry/IPR011914 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 InterPro IPR023030 http://www.ebi.ac.uk/interpro/entry/IPR023030 InterPro IPR029056 http://www.ebi.ac.uk/interpro/entry/IPR029056 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Gene ecj:JW3024 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3024 KEGG_Gene eco:b3052 http://www.genome.jp/dbget-bin/www_bget?eco:b3052 KEGG_Orthology KO:K03272 http://www.genome.jp/dbget-bin/www_bget?KO:K03272 KEGG_Pathway ko00540 http://www.genome.jp/kegg-bin/show_pathway?ko00540 KEGG_Reaction rn:R05644 http://www.genome.jp/dbget-bin/www_bget?rn:R05644 KEGG_Reaction rn:R05646 http://www.genome.jp/dbget-bin/www_bget?rn:R05646 OMA ILHKGHA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ILHKGHA PROSITE PS00583 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00583 PSORT swissprot:HLDE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HLDE_ECOLI PSORT-B swissprot:HLDE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HLDE_ECOLI PSORT2 swissprot:HLDE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HLDE_ECOLI Pfam PF00294 http://pfam.xfam.org/family/PF00294 Pfam PF01467 http://pfam.xfam.org/family/PF01467 Phobius swissprot:HLDE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HLDE_ECOLI PhylomeDB P76658 http://phylomedb.org/?seqid=P76658 ProteinModelPortal P76658 http://www.proteinmodelportal.org/query/uniprot/P76658 PubMed 10629197 http://www.ncbi.nlm.nih.gov/pubmed/10629197 PubMed 11751812 http://www.ncbi.nlm.nih.gov/pubmed/11751812 PubMed 16030223 http://www.ncbi.nlm.nih.gov/pubmed/16030223 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417524 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417524 RefSeq WP_000869178 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000869178 SMR P76658 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76658 STRING 511145.b3052 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3052&targetmode=cogs STRING COG2870 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2870&targetmode=cogs SUPFAM SSF53613 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53613 TIGRFAMs TIGR00125 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00125 TIGRFAMs TIGR02198 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02198 TIGRFAMs TIGR02199 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02199 UniProtKB HLDE_ECOLI http://www.uniprot.org/uniprot/HLDE_ECOLI UniProtKB-AC P76658 http://www.uniprot.org/uniprot/P76658 charge swissprot:HLDE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HLDE_ECOLI eggNOG COG2870 http://eggnogapi.embl.de/nog_data/html/tree/COG2870 eggNOG ENOG4105DW0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DW0 epestfind swissprot:HLDE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HLDE_ECOLI garnier swissprot:HLDE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HLDE_ECOLI helixturnhelix swissprot:HLDE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HLDE_ECOLI hmoment swissprot:HLDE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HLDE_ECOLI iep swissprot:HLDE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HLDE_ECOLI inforesidue swissprot:HLDE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HLDE_ECOLI octanol swissprot:HLDE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HLDE_ECOLI pepcoil swissprot:HLDE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HLDE_ECOLI pepdigest swissprot:HLDE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HLDE_ECOLI pepinfo swissprot:HLDE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HLDE_ECOLI pepnet swissprot:HLDE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HLDE_ECOLI pepstats swissprot:HLDE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HLDE_ECOLI pepwheel swissprot:HLDE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HLDE_ECOLI pepwindow swissprot:HLDE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HLDE_ECOLI sigcleave swissprot:HLDE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HLDE_ECOLI ## Database ID URL or Descriptions # BioGrid 4263450 20 # EcoGene EG10816 rbsC # FUNCTION RBSC_ECOLI Part of the ABC transporter complex RbsABC involved in ribose import. Probably responsible for the translocation of the substrate across the membrane. {ECO 0000269|PubMed 25533465, ECO 0000269|PubMed 6327617}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IBA:GO_Central. # GO_function GO:0015145 monosaccharide transmembrane transporter activity; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # InterPro IPR001851 ABC_transp_permease # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00212 Ribose transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism RBSC_ECOLI Escherichia coli (strain K12) # PATRIC 32122999 VBIEscCol129921_3875 # PIR G65178 G65178 # Pfam PF02653 BPD_transp_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Ribose import permease protein RbsC {ECO 0000305} # RefSeq NP_418206 NC_000913.3 # RefSeq WP_000211858 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION RBSC_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 9922273}; Multi- pass membrane protein {ECO 0000305|PubMed 9922273}. # SUBUNIT The complex is composed of an ATP-binding protein (RbsA), two transmembrane proteins (RbsC) and a solute-binding protein (RbsB). {ECO:0000269|PubMed 25533465}. # TCDB 3.A.1.2 the atp-binding cassette (abc) superfamily # eggNOG COG1172 LUCA # eggNOG ENOG4105CNN Bacteria BLAST swissprot:RBSC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RBSC_ECOLI BioCyc ECOL316407:JW3729-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3729-MONOMER BioCyc EcoCyc:RBSC-MONOMER http://biocyc.org/getid?id=EcoCyc:RBSC-MONOMER BioCyc MetaCyc:RBSC-MONOMER http://biocyc.org/getid?id=MetaCyc:RBSC-MONOMER COG COG1172 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1172 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M114.621573 http://dx.doi.org/10.1074/jbc.M114.621573 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M13169 http://www.ebi.ac.uk/ena/data/view/M13169 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0809 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0809 EcoGene EG10816 http://www.ecogene.org/geneInfo.php?eg_id=EG10816 EnsemblBacteria AAC76773 http://www.ensemblgenomes.org/id/AAC76773 EnsemblBacteria AAC76773 http://www.ensemblgenomes.org/id/AAC76773 EnsemblBacteria BAE77538 http://www.ensemblgenomes.org/id/BAE77538 EnsemblBacteria BAE77538 http://www.ensemblgenomes.org/id/BAE77538 EnsemblBacteria BAE77538 http://www.ensemblgenomes.org/id/BAE77538 EnsemblBacteria b3750 http://www.ensemblgenomes.org/id/b3750 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015145 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GeneID 948262 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948262 HOGENOM HOG000212232 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000212232&db=HOGENOM6 InParanoid P0AGI1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGI1 InterPro IPR001851 http://www.ebi.ac.uk/interpro/entry/IPR001851 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3729 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3729 KEGG_Gene eco:b3750 http://www.genome.jp/dbget-bin/www_bget?eco:b3750 KEGG_Orthology KO:K10440 http://www.genome.jp/dbget-bin/www_bget?KO:K10440 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA LAVMIDN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LAVMIDN PSORT swissprot:RBSC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RBSC_ECOLI PSORT-B swissprot:RBSC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RBSC_ECOLI PSORT2 swissprot:RBSC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RBSC_ECOLI Pfam PF02653 http://pfam.xfam.org/family/PF02653 Phobius swissprot:RBSC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RBSC_ECOLI PhylomeDB P0AGI1 http://phylomedb.org/?seqid=P0AGI1 ProteinModelPortal P0AGI1 http://www.proteinmodelportal.org/query/uniprot/P0AGI1 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 25533465 http://www.ncbi.nlm.nih.gov/pubmed/25533465 PubMed 3011793 http://www.ncbi.nlm.nih.gov/pubmed/3011793 PubMed 6327617 http://www.ncbi.nlm.nih.gov/pubmed/6327617 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9922273 http://www.ncbi.nlm.nih.gov/pubmed/9922273 RefSeq NP_418206 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418206 RefSeq WP_000211858 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000211858 SMR P0AGI1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AGI1 STRING 511145.b3750 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3750&targetmode=cogs STRING COG1172 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1172&targetmode=cogs TCDB 3.A.1.2 http://www.tcdb.org/search/result.php?tc=3.A.1.2 UniProtKB RBSC_ECOLI http://www.uniprot.org/uniprot/RBSC_ECOLI UniProtKB-AC P0AGI1 http://www.uniprot.org/uniprot/P0AGI1 charge swissprot:RBSC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RBSC_ECOLI eggNOG COG1172 http://eggnogapi.embl.de/nog_data/html/tree/COG1172 eggNOG ENOG4105CNN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CNN epestfind swissprot:RBSC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RBSC_ECOLI garnier swissprot:RBSC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RBSC_ECOLI helixturnhelix swissprot:RBSC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RBSC_ECOLI hmoment swissprot:RBSC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RBSC_ECOLI iep swissprot:RBSC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RBSC_ECOLI inforesidue swissprot:RBSC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RBSC_ECOLI octanol swissprot:RBSC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RBSC_ECOLI pepcoil swissprot:RBSC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RBSC_ECOLI pepdigest swissprot:RBSC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RBSC_ECOLI pepinfo swissprot:RBSC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RBSC_ECOLI pepnet swissprot:RBSC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RBSC_ECOLI pepstats swissprot:RBSC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RBSC_ECOLI pepwheel swissprot:RBSC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RBSC_ECOLI pepwindow swissprot:RBSC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RBSC_ECOLI sigcleave swissprot:RBSC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RBSC_ECOLI ## Database ID URL or Descriptions # AltName DAPD_ECOLI Tetrahydrodipicolinate N-succinyltransferase # BIOPHYSICOCHEMICAL PROPERTIES DAPD_ECOLI Kinetic parameters KM=15 uM for succinyl-CoA (at pH 7.4) {ECO 0000269|PubMed 9365916}; KM=22 uM for tetrahydrodipicolinate (THDPA) (at pH 7.4) {ECO 0000269|PubMed 9365916}; pH dependence Optimum pH is 8.2. {ECO 0000269|PubMed 9365916}; # CATALYTIC ACTIVITY Succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine- 2,6-dicarboxylate + H(2)O = CoA + N-succinyl-L-2-amino-6- oxoheptanedioate. {ECO:0000269|PubMed 9365916}. # ENZYME REGULATION Inhibited by N-ethylmaleimide, p- chloromercuriphenyl sulfonate, cobalt and copper ions. {ECO:0000269|PubMed 9365916}. # EcoGene EG10207 dapD # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008666 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity; IDA:EcoCyc. # GO_process GO:0009085 lysine biosynthetic process; IDA:EcoCyc. # GO_process GO:0009089 lysine biosynthetic process via diaminopimelate; IEA:UniProtKB-HAMAP. # GO_process GO:0019877 diaminopimelate biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 1.10.166.10 -; 1. # HAMAP MF_00811 DapD # IntAct P0A9D8 5 # InterPro IPR001451 Hexapep # InterPro IPR005664 DapD_Trfase_Hexpep_rpt_fam # InterPro IPR011004 Trimer_LpxA-like # InterPro IPR018357 Hexapep_transf_CS # InterPro IPR023180 THP_succinylTrfase_dom1 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00300 Lysine biosynthesis # Organism DAPD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR19136:SF52 PTHR19136:SF52 # PATHWAY Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route) step 1/3. # PATRIC 32115439 VBIEscCol129921_0171 # PIR F64740 XNECSD # PROSITE PS00101 HEXAPEP_TRANSFERASES # Pfam PF00132 Hexapep # Pfam PF14602 Hexapep_2 # Pfam PF14805 THDPS_N_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DAPD_ECOLI 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase # RefSeq NP_414708 NC_000913.3 # RefSeq WP_001186650 NZ_LN832404.1 # SIMILARITY Belongs to the transferase hexapeptide repeat family. {ECO 0000305}. # SUBCELLULAR LOCATION DAPD_ECOLI Cytoplasm. # SUBUNIT Homotrimer. {ECO:0000269|PubMed 9365916}. # SUPFAM SSF51161 SSF51161 # TIGRFAMs TIGR00965 dapD # UniPathway UPA00034 UER00019 # eggNOG COG2171 LUCA # eggNOG ENOG4105DMJ Bacteria BLAST swissprot:DAPD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DAPD_ECOLI BioCyc ECOL316407:JW0161-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0161-MONOMER BioCyc EcoCyc:MONOMER0-2001 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2001 BioCyc MetaCyc:MONOMER0-2001 http://biocyc.org/getid?id=MetaCyc:MONOMER0-2001 COG COG2171 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2171 DIP DIP-31866N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31866N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1111/j.1365-2958.1993.tb01706.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb01706.x DOI 10.1111/j.1469-7793.1997.439be.x http://dx.doi.org/10.1111/j.1469-7793.1997.439be.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.117 http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.117 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K02970 http://www.ebi.ac.uk/ena/data/view/K02970 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EMBL Z21842 http://www.ebi.ac.uk/ena/data/view/Z21842 ENZYME 2.3.1.117 http://enzyme.expasy.org/EC/2.3.1.117 EchoBASE EB0203 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0203 EcoGene EG10207 http://www.ecogene.org/geneInfo.php?eg_id=EG10207 EnsemblBacteria AAC73277 http://www.ensemblgenomes.org/id/AAC73277 EnsemblBacteria AAC73277 http://www.ensemblgenomes.org/id/AAC73277 EnsemblBacteria BAB96742 http://www.ensemblgenomes.org/id/BAB96742 EnsemblBacteria BAB96742 http://www.ensemblgenomes.org/id/BAB96742 EnsemblBacteria BAB96742 http://www.ensemblgenomes.org/id/BAB96742 EnsemblBacteria b0166 http://www.ensemblgenomes.org/id/b0166 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008666 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008666 GO_process GO:0009085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009085 GO_process GO:0009089 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009089 GO_process GO:0019877 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019877 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 1.10.166.10 http://www.cathdb.info/version/latest/superfamily/1.10.166.10 GeneID 944862 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944862 HAMAP MF_00811 http://hamap.expasy.org/unirule/MF_00811 HOGENOM HOG000003295 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000003295&db=HOGENOM6 InParanoid P0A9D8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9D8 IntAct P0A9D8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9D8* IntEnz 2.3.1.117 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.117 InterPro IPR001451 http://www.ebi.ac.uk/interpro/entry/IPR001451 InterPro IPR005664 http://www.ebi.ac.uk/interpro/entry/IPR005664 InterPro IPR011004 http://www.ebi.ac.uk/interpro/entry/IPR011004 InterPro IPR018357 http://www.ebi.ac.uk/interpro/entry/IPR018357 InterPro IPR023180 http://www.ebi.ac.uk/interpro/entry/IPR023180 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0161 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0161 KEGG_Gene eco:b0166 http://www.genome.jp/dbget-bin/www_bget?eco:b0166 KEGG_Orthology KO:K00674 http://www.genome.jp/dbget-bin/www_bget?KO:K00674 KEGG_Pathway ko00300 http://www.genome.jp/kegg-bin/show_pathway?ko00300 KEGG_Reaction rn:R04365 http://www.genome.jp/dbget-bin/www_bget?rn:R04365 OMA WVKKAVV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WVKKAVV PANTHER PTHR19136:SF52 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19136:SF52 PROSITE PS00101 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00101 PSORT swissprot:DAPD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DAPD_ECOLI PSORT-B swissprot:DAPD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DAPD_ECOLI PSORT2 swissprot:DAPD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DAPD_ECOLI Pfam PF00132 http://pfam.xfam.org/family/PF00132 Pfam PF14602 http://pfam.xfam.org/family/PF14602 Pfam PF14805 http://pfam.xfam.org/family/PF14805 Phobius swissprot:DAPD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DAPD_ECOLI PhylomeDB P0A9D8 http://phylomedb.org/?seqid=P0A9D8 ProteinModelPortal P0A9D8 http://www.proteinmodelportal.org/query/uniprot/P0A9D8 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6094577 http://www.ncbi.nlm.nih.gov/pubmed/6094577 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 8412694 http://www.ncbi.nlm.nih.gov/pubmed/8412694 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9365916 http://www.ncbi.nlm.nih.gov/pubmed/9365916 RefSeq NP_414708 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414708 RefSeq WP_001186650 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001186650 SMR P0A9D8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9D8 STRING 511145.b0166 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0166&targetmode=cogs STRING COG2171 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2171&targetmode=cogs SUPFAM SSF51161 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51161 SWISS-2DPAGE P0A9D8 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A9D8 TIGRFAMs TIGR00965 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00965 UniProtKB DAPD_ECOLI http://www.uniprot.org/uniprot/DAPD_ECOLI UniProtKB-AC P0A9D8 http://www.uniprot.org/uniprot/P0A9D8 charge swissprot:DAPD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DAPD_ECOLI eggNOG COG2171 http://eggnogapi.embl.de/nog_data/html/tree/COG2171 eggNOG ENOG4105DMJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DMJ epestfind swissprot:DAPD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DAPD_ECOLI garnier swissprot:DAPD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DAPD_ECOLI helixturnhelix swissprot:DAPD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DAPD_ECOLI hmoment swissprot:DAPD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DAPD_ECOLI iep swissprot:DAPD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DAPD_ECOLI inforesidue swissprot:DAPD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DAPD_ECOLI octanol swissprot:DAPD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DAPD_ECOLI pepcoil swissprot:DAPD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DAPD_ECOLI pepdigest swissprot:DAPD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DAPD_ECOLI pepinfo swissprot:DAPD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DAPD_ECOLI pepnet swissprot:DAPD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DAPD_ECOLI pepstats swissprot:DAPD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DAPD_ECOLI pepwheel swissprot:DAPD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DAPD_ECOLI pepwindow swissprot:DAPD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DAPD_ECOLI sigcleave swissprot:DAPD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DAPD_ECOLI ## Database ID URL or Descriptions # AltName 2,3-dihydroxybenzoate-AMP ligase {ECO:0000303|PubMed 2531000} # AltName 2,3-dihydroxybenzoate-AMP synthase {ECO 0000305} # AltName Dihydroxybenzoic acid-activating enzyme {ECO:0000303|PubMed 2531000} # AltName Enterochelin synthase E {ECO:0000303|PubMed 9485415} # AltName S-dihydroxybenzoyltransferase {ECO:0000305|PubMed 20359185} # BIOPHYSICOCHEMICAL PROPERTIES ENTE_ECOLI Kinetic parameters KM=0.4 uM for holo-EntB (at pH 8.8 and 37 degrees Celsius) {ECO 0000269|PubMed 9214294}; KM=0.5 uM for holo-EntB {ECO 0000269|PubMed 16567620}; KM=2.5 uM for DHB (at pH 7.8 and 25 degrees Celsius) {ECO 0000269|PubMed 20359185}; KM=2.7 uM for DHB {ECO 0000269|PubMed 2531000}; KM=2.9 uM for DHB {ECO 0000269|PubMed 20845982}; KM=2.9 uM for holo-EntB (at pH 7.8 and 25 degrees Celsius) {ECO 0000269|PubMed 20359185}; KM=23.3 uM for holo-EntB (at pH 7.5 and 37 degrees Celsius) {ECO 0000269|PubMed 16632253}; KM=70 uM for 3-hydroxybenzoate (at pH 7.8 and 25 degrees Celsius) {ECO 0000269|PubMed 20359185}; KM=70 uM for salicylate (at pH 7.8 and 25 degrees Celsius) {ECO 0000269|PubMed 20359185}; KM=400 uM for 5,5-diadenosine tetraphosphate {ECO 0000269|PubMed 19852513}; KM=430 uM for ATP (at pH 7.8 and 25 degrees Celsius) {ECO 0000269|PubMed 20359185}; KM=1200 uM for ATP {ECO 0000269|PubMed 2531000}; KM=3100 uM for 4-aminosalicylate (at pH 7.8 and 25 degrees Celsius) {ECO 0000269|PubMed 20359185}; KM=34.2 mM for D-pantetheine (at pH 7.8 and 25 degrees Celsius) {ECO 0000269|PubMed 20359185}; Vmax=3168.2 pmol/min/mg enzyme {ECO 0000269|PubMed 20845982}; Note=Kcat is 0.3 sec(-1) for 2,3-dihydroxybenzoate-AMP ligase activity with 3-hydroxybenzoate as substrate (at pH 7.8 and 25 degrees Celsius). Kcat is 0.8 sec(-1) for 2,3-dihydroxybenzoate- AMP ligase activity with salicylate as substrate (at pH 7.8 and 25 degrees Celsius). Kcat is 0.9 sec(-1) for S- dihydroxybenzoyltransferase activity with D-pantetheine as substrate (at pH 7.8 and 25 degrees Celsius). Kcat is 2.8 sec(- 1) for 2,3-dihydroxybenzoate-AMP ligase activity with ATP and DHB as substrates (at pH 7.8 and 25 degrees Celsius). Kcat is 2.8 sec(-1) for S-dihydroxybenzoyltransferase activity with holo-EntB as substrate (at pH 7.8 and 25 degrees Celsius). Kcat is 4.4 sec(-1) for 2,3-dihydroxybenzoate-AMP ligase activity with 4-aminosalicylate as substrate (at pH 7.8 and 25 degrees Celsius). Kcat is 5.94 sec(-1) for S-dihydroxybenzoyltransferase activity with holo-EntB as substrate (at pH 7.8 and 25 degrees Celsius). Kcat is 100 min(-1) for S-dihydroxybenzoyltransferase activity with holo-EntB as substrate (at pH 8.8 and 37 degrees Celsius). Kcat is 140 min(-1) for S-dihydroxybenzoyltransferase activity with holo-EntB as substrate. {ECO 0000269|PubMed 16567620, ECO 0000269|PubMed 16632253, ECO 0000269|PubMed 20359185, ECO 0000269|PubMed 9214294}; # BRENDA 6.3.2.14 2026 # BioGrid 4259905 320 # CATALYTIC ACTIVITY ENTE_ECOLI (2,3-dihydroxybenzoyl)adenylate + holo-entB = adenosine 5'-monophosphate + aryl-holo-entB. {ECO 0000269|PubMed 10688898, ECO 0000269|PubMed 16567620, ECO 0000269|PubMed 19852513, ECO 0000269|PubMed 20359185, ECO 0000269|PubMed 20845982, ECO 0000269|PubMed 9214294, ECO 0000269|PubMed 9485415}. # CATALYTIC ACTIVITY ENTE_ECOLI 6 ATP + 3 2,3-dihydroxybenzoate + 3 L-serine = enterobactin + 6 AMP + 6 diphosphate. {ECO 0000269|PubMed 10688898, ECO 0000269|PubMed 16567620, ECO 0000269|PubMed 19852513, ECO 0000269|PubMed 20359185, ECO 0000269|PubMed 20845982, ECO 0000269|PubMed 2531000, ECO 0000269|PubMed 9214294}. # CATALYTIC ACTIVITY ENTE_ECOLI ATP + 2,3-dihydroxybenzoate = diphosphate + (2,3-dihydroxybenzoyl)adenylate. {ECO 0000269|PubMed 10688898, ECO 0000269|PubMed 16567620, ECO 0000269|PubMed 19852513, ECO 0000269|PubMed 20359185, ECO 0000269|PubMed 20845982, ECO 0000269|PubMed 2531000}. # ENZYME REGULATION ENTE_ECOLI Inhibited by the adenylate analogs, 5'-O-[N- (salicyl)sulfamoyl]adenosine (Sal-AMS) and 5'-O-[N-(2,3- dihydroxybenzoyl)sulfamoyl]adenosine (DHB-AMS). Adenylation of 2,3-dihydroxybenzoate (DHB) is enhanced by a protein-protein interaction between the EntA and EntE. {ECO 0000269|PubMed 20359185, ECO 0000269|PubMed 21166461}. # EcoGene EG10263 entE # FUNCTION ENTE_ECOLI Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3-dihydroxybenzoyl)-serine. The serine trilactone serves as a scaffolding for the three catechol functionalities that provide hexadentate coordination for the tightly ligated iron(2+) atoms. EntE proccesses via a two-step adenylation- ligation reaction (bi-uni-uni-bi ping-pong mechanism). First, it catalyzes the activation of the carboxylate group of 2,3- dihydroxy-benzoate (DHB), via a reversible ATP-dependent pyrophosphate exchange reactions to yield the acyladenylate intermediate 2,3-dihydroxybenzoyl-AMP. It can also transfer AMP to salicylate, 2,4-dihydroxybenzoate, gentisate and 2,3,4- trihydroxybenzoate. In the second step, DHB is transferred from 2,3-dihydroxybenzoyl-AMP onto the phosphopantetheinylated EntB (holo-EntB) to form DHB-holo-EntB. Then this product will serve in the formation of the amide bond between 2,3-dihydroxybenzoate (DHB) and L-serine. It can also transfer adenylated salicylate to holo-EntB. {ECO 0000269|PubMed 10688898, ECO 0000269|PubMed 16567620, ECO 0000269|PubMed 16632253, ECO 0000269|PubMed 19699210, ECO 0000269|PubMed 19852513, ECO 0000269|PubMed 20359185, ECO 0000269|PubMed 20845982, ECO 0000269|PubMed 21166461, ECO 0000269|PubMed 2531000, ECO 0000269|PubMed 9214294}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0016020 membrane; IEA:UniProtKB-SubCell. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0008668 (2,3-dihydroxybenzoyl)adenylate synthase activity; IDA:EcoCyc. # GO_function GO:0016746 transferase activity, transferring acyl groups; IEA:UniProtKB-KW. # GO_function GO:0047527 2,3-dihydroxybenzoate-serine ligase activity; IDA:UniProtKB. # GO_process GO:0009239 enterobactin biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0019748 secondary metabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0051186 cofactor metabolic process # INDUCTION ENTE_ECOLI Under conditions of iron deficiency and by the fur protein. {ECO 0000269|PubMed 2521621, ECO 0000269|PubMed 6227609}. # IntAct P10378 13 # InterPro IPR000873 AMP-dep_Synth/Lig # InterPro IPR011963 DHB_AMP_lig # InterPro IPR020845 AMP-binding_CS # InterPro IPR025110 AMP-bd_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01008 Polyketide biosynthesis proteins # KEGG_Pathway ko01053 Biosynthesis of siderophore group nonribosomal peptides # MISCELLANEOUS In the absence of holo-EntB, EntE can transfer the adenylate moiety of the 2,3-dihydroxybenzoyl-AMP intermediate to ATP, generating the stress signaling molecule Ap4A involved in the regulation of cell division during oxidative stress, and releasing 2,3-dihydroxybenzoate. It seems that the expression of EntE during iron starvation produces Ap(4)A to slow growth until intracellular iron stores can be restored. {ECO:0000269|PubMed 19852513}. # Organism ENTE_ECOLI Escherichia coli (strain K12) # PATHWAY Siderophore biosynthesis; enterobactin biosynthesis. {ECO:0000305|PubMed 9485415}. # PATRIC 32116364 VBIEscCol129921_0622 # PDB 3RG2 X-ray; 3.10 A; A/B/C/D/E/F/G/H/I/J=1-536 # PDB 4IZ6 X-ray; 2.40 A; A/B=1-536 # PIR H64792 SYECEB # PROSITE PS00455 AMP_BINDING # Pfam PF00501 AMP-binding # Pfam PF13193 AMP-binding_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Enterobactin synthase component E {ECO:0000303|PubMed 9485415} # RefSeq NP_415126 NC_000913.3 # RefSeq WP_000026812 NZ_LN832404.1 # SIMILARITY Belongs to the ATP-dependent AMP-binding enzyme family. EntE subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION ENTE_ECOLI Membrane {ECO 0000269|PubMed 10692387}. # SUBUNIT ENTE_ECOLI Proteins EntB, EntD, EntE, and EntF form a multienzyme complex called enterobactin synthase. Monomer. EntA and EntE interact together. {ECO 0000269|PubMed 21166461, ECO 0000269|PubMed 22365602, ECO 0000269|PubMed 23897471, ECO 0000269|PubMed 2531000, ECO 0000269|PubMed 9485415}. # TIGRFAMs TIGR02275 DHB_AMP_lig # eggNOG COG1021 LUCA # eggNOG ENOG4108IQC Bacteria BLAST swissprot:ENTE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ENTE_ECOLI BioCyc ECOL316407:JW0586-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0586-MONOMER BioCyc EcoCyc:ENTE-MONOMER http://biocyc.org/getid?id=EcoCyc:ENTE-MONOMER BioCyc MetaCyc:ENTE-MONOMER http://biocyc.org/getid?id=MetaCyc:ENTE-MONOMER COG COG1021 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1021 DIP DIP-9515N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9515N DOI 10.1016/0378-1097(89)90450-3 http://dx.doi.org/10.1016/0378-1097(89)90450-3 DOI 10.1016/0378-1097(90)90120-F http://dx.doi.org/10.1016/0378-1097(90)90120-F DOI 10.1016/j.chembiol.2006.02.005 http://dx.doi.org/10.1016/j.chembiol.2006.02.005 DOI 10.1016/j.chembiol.2011.11.013 http://dx.doi.org/10.1016/j.chembiol.2011.11.013 DOI 10.1016/j.jmb.2009.08.036 http://dx.doi.org/10.1016/j.jmb.2009.08.036 DOI 10.1021/bi00443a008 http://dx.doi.org/10.1021/bi00443a008 DOI 10.1021/bi100350c http://dx.doi.org/10.1021/bi100350c DOI 10.1021/bi1012854 http://dx.doi.org/10.1021/bi1012854 DOI 10.1021/bi101558v http://dx.doi.org/10.1021/bi101558v DOI 10.1021/bi901680m http://dx.doi.org/10.1021/bi901680m DOI 10.1021/bi970453p http://dx.doi.org/10.1021/bi970453p DOI 10.1021/bi9726584 http://dx.doi.org/10.1021/bi9726584 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.040572897 http://dx.doi.org/10.1073/pnas.040572897 DOI 10.1073/pnas.0601038103 http://dx.doi.org/10.1073/pnas.0601038103 DOI 10.1107/S0907444913009372 http://dx.doi.org/10.1107/S0907444913009372 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.6.1768-1773.2000 http://dx.doi.org/10.1128/JB.182.6.1768-1773.2000 EC_number EC:2.5.1.- {ECO:0000269|PubMed:10688898, ECO:0000269|PubMed:16567620, ECO:0000269|PubMed:19852513, ECO:0000269|PubMed:20359185, ECO:0000269|PubMed:20845982, ECO:0000269|PubMed:9214294} http://www.genome.jp/dbget-bin/www_bget?EC:2.5.1.- {ECO:0000269|PubMed:10688898, ECO:0000269|PubMed:16567620, ECO:0000269|PubMed:19852513, ECO:0000269|PubMed:20359185, ECO:0000269|PubMed:20845982, ECO:0000269|PubMed:9214294} EC_number EC:2.7.7.58 {ECO:0000269|PubMed:10688898, ECO:0000269|PubMed:16567620, ECO:0000269|PubMed:19852513, ECO:0000269|PubMed:20359185, ECO:0000269|PubMed:20845982, ECO:0000269|PubMed:2531000} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.58 {ECO:0000269|PubMed:10688898, ECO:0000269|PubMed:16567620, ECO:0000269|PubMed:19852513, ECO:0000269|PubMed:20359185, ECO:0000269|PubMed:20845982, ECO:0000269|PubMed:2531000} EC_number EC:6.3.2.14 {ECO:0000269|PubMed:10688898, ECO:0000269|PubMed:16567620, ECO:0000269|PubMed:19852513, ECO:0000269|PubMed:20359185, ECO:0000269|PubMed:20845982, ECO:0000269|PubMed:2531000, ECO:0000269|PubMed:9214294} http://www.genome.jp/dbget-bin/www_bget?EC:6.3.2.14 {ECO:0000269|PubMed:10688898, ECO:0000269|PubMed:16567620, ECO:0000269|PubMed:19852513, ECO:0000269|PubMed:20359185, ECO:0000269|PubMed:20845982, ECO:0000269|PubMed:2531000, ECO:0000269|PubMed:9214294} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M24148 http://www.ebi.ac.uk/ena/data/view/M24148 EMBL M36700 http://www.ebi.ac.uk/ena/data/view/M36700 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EMBL X15058 http://www.ebi.ac.uk/ena/data/view/X15058 ENZYME 2.5.1.- {ECO:0000269|PubMed:10688898, ECO:0000269|PubMed:16567620, ECO:0000269|PubMed:19852513, ECO:0000269|PubMed:20359185, ECO:0000269|PubMed:20845982, ECO:0000269|PubMed:9214294} http://enzyme.expasy.org/EC/2.5.1.- {ECO:0000269|PubMed:10688898, ECO:0000269|PubMed:16567620, ECO:0000269|PubMed:19852513, ECO:0000269|PubMed:20359185, ECO:0000269|PubMed:20845982, ECO:0000269|PubMed:9214294} ENZYME 2.7.7.58 {ECO:0000269|PubMed:10688898, ECO:0000269|PubMed:16567620, ECO:0000269|PubMed:19852513, ECO:0000269|PubMed:20359185, ECO:0000269|PubMed:20845982, ECO:0000269|PubMed:2531000} http://enzyme.expasy.org/EC/2.7.7.58 {ECO:0000269|PubMed:10688898, ECO:0000269|PubMed:16567620, ECO:0000269|PubMed:19852513, ECO:0000269|PubMed:20359185, ECO:0000269|PubMed:20845982, ECO:0000269|PubMed:2531000} ENZYME 6.3.2.14 {ECO:0000269|PubMed:10688898, ECO:0000269|PubMed:16567620, ECO:0000269|PubMed:19852513, ECO:0000269|PubMed:20359185, ECO:0000269|PubMed:20845982, ECO:0000269|PubMed:2531000, ECO:0000269|PubMed:9214294} http://enzyme.expasy.org/EC/6.3.2.14 {ECO:0000269|PubMed:10688898, ECO:0000269|PubMed:16567620, ECO:0000269|PubMed:19852513, ECO:0000269|PubMed:20359185, ECO:0000269|PubMed:20845982, ECO:0000269|PubMed:2531000, ECO:0000269|PubMed:9214294} EchoBASE EB0259 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0259 EcoGene EG10263 http://www.ecogene.org/geneInfo.php?eg_id=EG10263 EnsemblBacteria AAC73695 http://www.ensemblgenomes.org/id/AAC73695 EnsemblBacteria AAC73695 http://www.ensemblgenomes.org/id/AAC73695 EnsemblBacteria BAE76349 http://www.ensemblgenomes.org/id/BAE76349 EnsemblBacteria BAE76349 http://www.ensemblgenomes.org/id/BAE76349 EnsemblBacteria BAE76349 http://www.ensemblgenomes.org/id/BAE76349 EnsemblBacteria b0594 http://www.ensemblgenomes.org/id/b0594 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008668 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008668 GO_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GO_function GO:0047527 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047527 GO_process GO:0009239 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009239 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0019748 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019748 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GeneID 947426 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947426 HOGENOM HOG000230011 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230011&db=HOGENOM6 InParanoid P10378 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P10378 IntAct P10378 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P10378* IntEnz 2.5.1.- {ECO:0000269|PubMed:10688898, ECO:0000269|PubMed:16567620, ECO:0000269|PubMed:19852513, ECO:0000269|PubMed:20359185, ECO:0000269|PubMed:20845982, ECO:0000269|PubMed:9214294} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.5.1.- {ECO:0000269|PubMed:10688898, ECO:0000269|PubMed:16567620, ECO:0000269|PubMed:19852513, ECO:0000269|PubMed:20359185, ECO:0000269|PubMed:20845982, ECO:0000269|PubMed:9214294} IntEnz 2.7.7.58 {ECO:0000269|PubMed:10688898, ECO:0000269|PubMed:16567620, ECO:0000269|PubMed:19852513, ECO:0000269|PubMed:20359185, ECO:0000269|PubMed:20845982, ECO:0000269|PubMed:2531000} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.58 {ECO:0000269|PubMed:10688898, ECO:0000269|PubMed:16567620, ECO:0000269|PubMed:19852513, ECO:0000269|PubMed:20359185, ECO:0000269|PubMed:20845982, ECO:0000269|PubMed:2531000} IntEnz 6.3.2.14 {ECO:0000269|PubMed:10688898, ECO:0000269|PubMed:16567620, ECO:0000269|PubMed:19852513, ECO:0000269|PubMed:20359185, ECO:0000269|PubMed:20845982, ECO:0000269|PubMed:2531000, ECO:0000269|PubMed:9214294} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.2.14 {ECO:0000269|PubMed:10688898, ECO:0000269|PubMed:16567620, ECO:0000269|PubMed:19852513, ECO:0000269|PubMed:20359185, ECO:0000269|PubMed:20845982, ECO:0000269|PubMed:2531000, ECO:0000269|PubMed:9214294} InterPro IPR000873 http://www.ebi.ac.uk/interpro/entry/IPR000873 InterPro IPR011963 http://www.ebi.ac.uk/interpro/entry/IPR011963 InterPro IPR020845 http://www.ebi.ac.uk/interpro/entry/IPR020845 InterPro IPR025110 http://www.ebi.ac.uk/interpro/entry/IPR025110 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01008 http://www.genome.jp/dbget-bin/www_bget?ko01008 KEGG_Gene ecj:JW0586 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0586 KEGG_Gene eco:b0594 http://www.genome.jp/dbget-bin/www_bget?eco:b0594 KEGG_Orthology KO:K02363 http://www.genome.jp/dbget-bin/www_bget?KO:K02363 KEGG_Pathway ko01053 http://www.genome.jp/kegg-bin/show_pathway?ko01053 MINT MINT-1228110 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1228110 OMA RSNEICH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RSNEICH PDB 3RG2 http://www.ebi.ac.uk/pdbe-srv/view/entry/3RG2 PDB 4IZ6 http://www.ebi.ac.uk/pdbe-srv/view/entry/4IZ6 PDBsum 3RG2 http://www.ebi.ac.uk/pdbsum/3RG2 PDBsum 4IZ6 http://www.ebi.ac.uk/pdbsum/4IZ6 PROSITE PS00455 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00455 PSORT swissprot:ENTE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ENTE_ECOLI PSORT-B swissprot:ENTE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ENTE_ECOLI PSORT2 swissprot:ENTE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ENTE_ECOLI Pfam PF00501 http://pfam.xfam.org/family/PF00501 Pfam PF13193 http://pfam.xfam.org/family/PF13193 Phobius swissprot:ENTE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ENTE_ECOLI PhylomeDB P10378 http://phylomedb.org/?seqid=P10378 ProteinModelPortal P10378 http://www.proteinmodelportal.org/query/uniprot/P10378 PubMed 10688898 http://www.ncbi.nlm.nih.gov/pubmed/10688898 PubMed 10692387 http://www.ncbi.nlm.nih.gov/pubmed/10692387 PubMed 16567620 http://www.ncbi.nlm.nih.gov/pubmed/16567620 PubMed 16632253 http://www.ncbi.nlm.nih.gov/pubmed/16632253 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19699210 http://www.ncbi.nlm.nih.gov/pubmed/19699210 PubMed 19852513 http://www.ncbi.nlm.nih.gov/pubmed/19852513 PubMed 20359185 http://www.ncbi.nlm.nih.gov/pubmed/20359185 PubMed 20845982 http://www.ncbi.nlm.nih.gov/pubmed/20845982 PubMed 2110093 http://www.ncbi.nlm.nih.gov/pubmed/2110093 PubMed 21166461 http://www.ncbi.nlm.nih.gov/pubmed/21166461 PubMed 22365602 http://www.ncbi.nlm.nih.gov/pubmed/22365602 PubMed 23897471 http://www.ncbi.nlm.nih.gov/pubmed/23897471 PubMed 2521621 http://www.ncbi.nlm.nih.gov/pubmed/2521621 PubMed 2521622 http://www.ncbi.nlm.nih.gov/pubmed/2521622 PubMed 2525505 http://www.ncbi.nlm.nih.gov/pubmed/2525505 PubMed 2531000 http://www.ncbi.nlm.nih.gov/pubmed/2531000 PubMed 6227609 http://www.ncbi.nlm.nih.gov/pubmed/6227609 PubMed 9214294 http://www.ncbi.nlm.nih.gov/pubmed/9214294 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9485415 http://www.ncbi.nlm.nih.gov/pubmed/9485415 RefSeq NP_415126 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415126 RefSeq WP_000026812 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000026812 SMR P10378 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P10378 STRING 511145.b0594 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0594&targetmode=cogs STRING COG1021 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1021&targetmode=cogs TIGRFAMs TIGR02275 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02275 UniProtKB ENTE_ECOLI http://www.uniprot.org/uniprot/ENTE_ECOLI UniProtKB-AC P10378 http://www.uniprot.org/uniprot/P10378 charge swissprot:ENTE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ENTE_ECOLI eggNOG COG1021 http://eggnogapi.embl.de/nog_data/html/tree/COG1021 eggNOG ENOG4108IQC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108IQC epestfind swissprot:ENTE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ENTE_ECOLI garnier swissprot:ENTE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ENTE_ECOLI helixturnhelix swissprot:ENTE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ENTE_ECOLI hmoment swissprot:ENTE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ENTE_ECOLI iep swissprot:ENTE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ENTE_ECOLI inforesidue swissprot:ENTE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ENTE_ECOLI octanol swissprot:ENTE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ENTE_ECOLI pepcoil swissprot:ENTE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ENTE_ECOLI pepdigest swissprot:ENTE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ENTE_ECOLI pepinfo swissprot:ENTE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ENTE_ECOLI pepnet swissprot:ENTE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ENTE_ECOLI pepstats swissprot:ENTE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ENTE_ECOLI pepwheel swissprot:ENTE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ENTE_ECOLI pepwindow swissprot:ENTE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ENTE_ECOLI sigcleave swissprot:ENTE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ENTE_ECOLI ## Database ID URL or Descriptions # BioGrid 4259547 11 # EcoGene EG14358 ymdF # InterPro IPR019626 Stress-induced_KGG_rpt # Organism YMDF_ECOLI Escherichia coli (strain K12) # PATRIC 32117235 VBIEscCol129921_1041 # PIR C64842 C64842 # Pfam PF10685 KGG; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YMDF_ECOLI Uncharacterized protein YmdF # RefSeq NP_415525 NC_000913.3 # RefSeq WP_001273658 NZ_LN832404.1 # SIMILARITY Belongs to the con-10 family. {ECO 0000305}. # eggNOG COG3729 LUCA # eggNOG ENOG4105XF5 Bacteria BLAST swissprot:YMDF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YMDF_ECOLI BioCyc ECOL316407:JW5136-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5136-MONOMER BioCyc EcoCyc:MONOMER0-2665 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2665 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4104 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4104 EcoGene EG14358 http://www.ecogene.org/geneInfo.php?eg_id=EG14358 EnsemblBacteria AAC74090 http://www.ensemblgenomes.org/id/AAC74090 EnsemblBacteria AAC74090 http://www.ensemblgenomes.org/id/AAC74090 EnsemblBacteria BAA35772 http://www.ensemblgenomes.org/id/BAA35772 EnsemblBacteria BAA35772 http://www.ensemblgenomes.org/id/BAA35772 EnsemblBacteria BAA35772 http://www.ensemblgenomes.org/id/BAA35772 EnsemblBacteria b4518 http://www.ensemblgenomes.org/id/b4518 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945598 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945598 HOGENOM HOG000201826 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000201826&db=HOGENOM6 InParanoid P56614 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P56614 IntAct P56614 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P56614* InterPro IPR019626 http://www.ebi.ac.uk/interpro/entry/IPR019626 KEGG_Gene ecj:JW5136 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5136 KEGG_Gene eco:b4518 http://www.genome.jp/dbget-bin/www_bget?eco:b4518 OMA MARDQER http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MARDQER PSORT swissprot:YMDF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YMDF_ECOLI PSORT-B swissprot:YMDF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YMDF_ECOLI PSORT2 swissprot:YMDF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YMDF_ECOLI Pfam PF10685 http://pfam.xfam.org/family/PF10685 Phobius swissprot:YMDF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YMDF_ECOLI PhylomeDB P56614 http://phylomedb.org/?seqid=P56614 ProteinModelPortal P56614 http://www.proteinmodelportal.org/query/uniprot/P56614 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415525 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415525 RefSeq WP_001273658 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001273658 STRING 511145.b4518 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4518&targetmode=cogs UniProtKB YMDF_ECOLI http://www.uniprot.org/uniprot/YMDF_ECOLI UniProtKB-AC P56614 http://www.uniprot.org/uniprot/P56614 charge swissprot:YMDF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YMDF_ECOLI eggNOG COG3729 http://eggnogapi.embl.de/nog_data/html/tree/COG3729 eggNOG ENOG4105XF5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105XF5 epestfind swissprot:YMDF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YMDF_ECOLI garnier swissprot:YMDF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YMDF_ECOLI helixturnhelix swissprot:YMDF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YMDF_ECOLI hmoment swissprot:YMDF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YMDF_ECOLI iep swissprot:YMDF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YMDF_ECOLI inforesidue swissprot:YMDF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YMDF_ECOLI octanol swissprot:YMDF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YMDF_ECOLI pepcoil swissprot:YMDF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YMDF_ECOLI pepdigest swissprot:YMDF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YMDF_ECOLI pepinfo swissprot:YMDF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YMDF_ECOLI pepnet swissprot:YMDF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YMDF_ECOLI pepstats swissprot:YMDF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YMDF_ECOLI pepwheel swissprot:YMDF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YMDF_ECOLI pepwindow swissprot:YMDF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YMDF_ECOLI sigcleave swissprot:YMDF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YMDF_ECOLI ## Database ID URL or Descriptions # BioGrid 4259970 4 # EcoGene EG10389 glnQ # FUNCTION GLNQ_ECOLI Part of the binding-protein-dependent transport system for glutamine. Probably responsible for energy coupling to the transport system. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0015424 amino acid-transporting ATPase activity; IEA:InterPro. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.300 -; 1. # INDUCTION GLNQ_ECOLI By lack of glutamine. # IntAct P10346 2 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # InterPro IPR030679 ABC_ATPase_HisP-typ # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00227 Glutamine transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism GLNQ_ECOLI Escherichia coli (strain K12) # PATRIC 32116821 VBIEscCol129921_0836 # PIR S03183 QRECGQ # PIRSF PIRSF039085 ABC_ATPase_HisP # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # Pfam PF00005 ABC_tran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLNQ_ECOLI Glutamine transport ATP-binding protein GlnQ # RefSeq NP_415330 NC_000913.3 # RefSeq WP_000569083 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA # SUBCELLULAR LOCATION GLNQ_ECOLI Cell inner membrane {ECO 0000269|PubMed 16079137}; Peripheral membrane protein {ECO 0000269|PubMed 16079137}. # SUBUNIT Heterotetramer with 2 subunits of GlnQ and 2 subunits of GlnP. {ECO:0000269|PubMed 16079137}. # SUPFAM SSF52540 SSF52540 # TCDB 3.A.1.3 the atp-binding cassette (abc) superfamily # eggNOG COG1126 LUCA # eggNOG ENOG4105CDA Bacteria BLAST swissprot:GLNQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLNQ_ECOLI BioCyc ECOL316407:JW0794-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0794-MONOMER BioCyc EcoCyc:GLNQ-MONOMER http://biocyc.org/getid?id=EcoCyc:GLNQ-MONOMER BioCyc MetaCyc:GLNQ-MONOMER http://biocyc.org/getid?id=MetaCyc:GLNQ-MONOMER COG COG1126 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1126 DIP DIP-9786N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9786N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1007/BF00430437 http://dx.doi.org/10.1007/BF00430437 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X14180 http://www.ebi.ac.uk/ena/data/view/X14180 EchoBASE EB0384 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0384 EcoGene EG10389 http://www.ecogene.org/geneInfo.php?eg_id=EG10389 EnsemblBacteria AAC73896 http://www.ensemblgenomes.org/id/AAC73896 EnsemblBacteria AAC73896 http://www.ensemblgenomes.org/id/AAC73896 EnsemblBacteria BAA35481 http://www.ensemblgenomes.org/id/BAA35481 EnsemblBacteria BAA35481 http://www.ensemblgenomes.org/id/BAA35481 EnsemblBacteria BAA35481 http://www.ensemblgenomes.org/id/BAA35481 EnsemblBacteria b0809 http://www.ensemblgenomes.org/id/b0809 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0015424 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015424 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945435 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945435 InParanoid P10346 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P10346 IntAct P10346 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P10346* InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR030679 http://www.ebi.ac.uk/interpro/entry/IPR030679 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0794 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0794 KEGG_Gene eco:b0809 http://www.genome.jp/dbget-bin/www_bget?eco:b0809 KEGG_Orthology KO:K10038 http://www.genome.jp/dbget-bin/www_bget?KO:K10038 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA ENPPSQR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ENPPSQR PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:GLNQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLNQ_ECOLI PSORT-B swissprot:GLNQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLNQ_ECOLI PSORT2 swissprot:GLNQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLNQ_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Phobius swissprot:GLNQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLNQ_ECOLI PhylomeDB P10346 http://phylomedb.org/?seqid=P10346 ProteinModelPortal P10346 http://www.proteinmodelportal.org/query/uniprot/P10346 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3027504 http://www.ncbi.nlm.nih.gov/pubmed/3027504 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_415330 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415330 RefSeq WP_000569083 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000569083 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P10346 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P10346 STRING 511145.b0809 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0809&targetmode=cogs STRING COG1126 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1126&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.3 http://www.tcdb.org/search/result.php?tc=3.A.1.3 UniProtKB GLNQ_ECOLI http://www.uniprot.org/uniprot/GLNQ_ECOLI UniProtKB-AC P10346 http://www.uniprot.org/uniprot/P10346 charge swissprot:GLNQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLNQ_ECOLI eggNOG COG1126 http://eggnogapi.embl.de/nog_data/html/tree/COG1126 eggNOG ENOG4105CDA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CDA epestfind swissprot:GLNQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLNQ_ECOLI garnier swissprot:GLNQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLNQ_ECOLI helixturnhelix swissprot:GLNQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLNQ_ECOLI hmoment swissprot:GLNQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLNQ_ECOLI iep swissprot:GLNQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLNQ_ECOLI inforesidue swissprot:GLNQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLNQ_ECOLI octanol swissprot:GLNQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLNQ_ECOLI pepcoil swissprot:GLNQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLNQ_ECOLI pepdigest swissprot:GLNQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLNQ_ECOLI pepinfo swissprot:GLNQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLNQ_ECOLI pepnet swissprot:GLNQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLNQ_ECOLI pepstats swissprot:GLNQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLNQ_ECOLI pepwheel swissprot:GLNQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLNQ_ECOLI pepwindow swissprot:GLNQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLNQ_ECOLI sigcleave swissprot:GLNQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLNQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4259897 4 # COFACTOR YBDR_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000250}; Note=Binds 2 Zn(2+) ions per subunit. {ECO 0000250}; # EcoGene EG13537 ybdR # GO_function GO:0008270 zinc ion binding; IEA:InterPro. # GO_function GO:0016491 oxidoreductase activity; IEA:UniProtKB-KW. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.720 -; 1. # Gene3D 3.90.180.10 -; 1. # IntAct P77316 6 # InterPro IPR002085 ADH_SF_Zn-type # InterPro IPR002328 ADH_Zn_CS # InterPro IPR011032 GroES-like # InterPro IPR013149 ADH_C # InterPro IPR013154 ADH_N # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR027399 ADH_N_assoc # Organism YBDR_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11695 PTHR11695; 3 # PATRIC 32116396 VBIEscCol129921_0638 # PIR F64794 F64794 # PROSITE PS00059 ADH_ZINC # Pfam PF00107 ADH_zinc_N # Pfam PF08240 ADH_N # Pfam PF13823 ADH_N_assoc # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBDR_ECOLI Uncharacterized zinc-type alcohol dehydrogenase-like protein YbdR # RefSeq NP_415141 NC_000913.3 # RefSeq WP_000646173 NZ_LN832404.1 # SIMILARITY Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. {ECO 0000305}. # SUPFAM SSF50129 SSF50129 # SUPFAM SSF51735 SSF51735 # eggNOG COG1063 LUCA # eggNOG ENOG4105E2A Bacteria BLAST swissprot:YBDR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBDR_ECOLI BioCyc ECOL316407:JW0601-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0601-MONOMER BioCyc EcoCyc:G6335-MONOMER http://biocyc.org/getid?id=EcoCyc:G6335-MONOMER DIP DIP-11355N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11355N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- EchoBASE EB3307 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3307 EcoGene EG13537 http://www.ecogene.org/geneInfo.php?eg_id=EG13537 EnsemblBacteria AAC73709 http://www.ensemblgenomes.org/id/AAC73709 EnsemblBacteria AAC73709 http://www.ensemblgenomes.org/id/AAC73709 EnsemblBacteria BAA35238 http://www.ensemblgenomes.org/id/BAA35238 EnsemblBacteria BAA35238 http://www.ensemblgenomes.org/id/BAA35238 EnsemblBacteria BAA35238 http://www.ensemblgenomes.org/id/BAA35238 EnsemblBacteria b0608 http://www.ensemblgenomes.org/id/b0608 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 Gene3D 3.90.180.10 http://www.cathdb.info/version/latest/superfamily/3.90.180.10 GeneID 949067 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949067 HOGENOM HOG000294694 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000294694&db=HOGENOM6 InParanoid P77316 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77316 IntAct P77316 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77316* IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR002085 http://www.ebi.ac.uk/interpro/entry/IPR002085 InterPro IPR002328 http://www.ebi.ac.uk/interpro/entry/IPR002328 InterPro IPR011032 http://www.ebi.ac.uk/interpro/entry/IPR011032 InterPro IPR013149 http://www.ebi.ac.uk/interpro/entry/IPR013149 InterPro IPR013154 http://www.ebi.ac.uk/interpro/entry/IPR013154 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR027399 http://www.ebi.ac.uk/interpro/entry/IPR027399 KEGG_Gene ecj:JW0601 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0601 KEGG_Gene eco:b0608 http://www.genome.jp/dbget-bin/www_bget?eco:b0608 OMA DYLDYRM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DYLDYRM PANTHER PTHR11695 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11695 PROSITE PS00059 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00059 PSORT swissprot:YBDR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBDR_ECOLI PSORT-B swissprot:YBDR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBDR_ECOLI PSORT2 swissprot:YBDR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBDR_ECOLI Pfam PF00107 http://pfam.xfam.org/family/PF00107 Pfam PF08240 http://pfam.xfam.org/family/PF08240 Pfam PF13823 http://pfam.xfam.org/family/PF13823 Phobius swissprot:YBDR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBDR_ECOLI PhylomeDB P77316 http://phylomedb.org/?seqid=P77316 ProteinModelPortal P77316 http://www.proteinmodelportal.org/query/uniprot/P77316 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415141 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415141 RefSeq WP_000646173 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000646173 SMR P77316 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77316 STRING 511145.b0608 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0608&targetmode=cogs SUPFAM SSF50129 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50129 SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB YBDR_ECOLI http://www.uniprot.org/uniprot/YBDR_ECOLI UniProtKB-AC P77316 http://www.uniprot.org/uniprot/P77316 charge swissprot:YBDR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBDR_ECOLI eggNOG COG1063 http://eggnogapi.embl.de/nog_data/html/tree/COG1063 eggNOG ENOG4105E2A http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E2A epestfind swissprot:YBDR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBDR_ECOLI garnier swissprot:YBDR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBDR_ECOLI helixturnhelix swissprot:YBDR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBDR_ECOLI hmoment swissprot:YBDR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBDR_ECOLI iep swissprot:YBDR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBDR_ECOLI inforesidue swissprot:YBDR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBDR_ECOLI octanol swissprot:YBDR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBDR_ECOLI pepcoil swissprot:YBDR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBDR_ECOLI pepdigest swissprot:YBDR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBDR_ECOLI pepinfo swissprot:YBDR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBDR_ECOLI pepnet swissprot:YBDR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBDR_ECOLI pepstats swissprot:YBDR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBDR_ECOLI pepwheel swissprot:YBDR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBDR_ECOLI pepwindow swissprot:YBDR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBDR_ECOLI sigcleave swissprot:YBDR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBDR_ECOLI ## Database ID URL or Descriptions # BioGrid 4260441 18 # EcoGene EG11999 yehM # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # Organism YEHM_ECOLI Escherichia coli (strain K12) # PATRIC 32119575 VBIEscCol129921_2198 # PIR G64979 G64979 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEHM_ECOLI Uncharacterized protein YehM # RefSeq NP_416624 NC_000913.3 # RefSeq WP_001294387 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA60483.1; Type=Frameshift; Positions=283, 403; Note=Produces three separate ORFs.; Evidence={ECO 0000305}; # eggNOG ENOG4105RD5 Bacteria # eggNOG ENOG410XPUH LUCA BLAST swissprot:YEHM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEHM_ECOLI BioCyc ECOL316407:JW2108-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2108-MONOMER BioCyc EcoCyc:EG11999-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11999-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1939 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1939 EcoGene EG11999 http://www.ecogene.org/geneInfo.php?eg_id=EG11999 EnsemblBacteria AAC75181 http://www.ensemblgenomes.org/id/AAC75181 EnsemblBacteria AAC75181 http://www.ensemblgenomes.org/id/AAC75181 EnsemblBacteria BAE76596 http://www.ensemblgenomes.org/id/BAE76596 EnsemblBacteria BAE76596 http://www.ensemblgenomes.org/id/BAE76596 EnsemblBacteria BAE76596 http://www.ensemblgenomes.org/id/BAE76596 EnsemblBacteria b2120 http://www.ensemblgenomes.org/id/b2120 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GeneID 946651 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946651 HOGENOM HOG000122178 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122178&db=HOGENOM6 InParanoid P33349 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33349 KEGG_Gene ecj:JW2108 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2108 KEGG_Gene eco:b2120 http://www.genome.jp/dbget-bin/www_bget?eco:b2120 OMA AWIEGFL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AWIEGFL PSORT swissprot:YEHM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEHM_ECOLI PSORT-B swissprot:YEHM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEHM_ECOLI PSORT2 swissprot:YEHM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEHM_ECOLI Phobius swissprot:YEHM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEHM_ECOLI PhylomeDB P33349 http://phylomedb.org/?seqid=P33349 ProteinModelPortal P33349 http://www.proteinmodelportal.org/query/uniprot/P33349 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416624 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416624 RefSeq WP_001294387 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001294387 STRING 511145.b2120 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2120&targetmode=cogs UniProtKB YEHM_ECOLI http://www.uniprot.org/uniprot/YEHM_ECOLI UniProtKB-AC P33349 http://www.uniprot.org/uniprot/P33349 charge swissprot:YEHM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEHM_ECOLI eggNOG ENOG4105RD5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105RD5 eggNOG ENOG410XPUH http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPUH epestfind swissprot:YEHM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEHM_ECOLI garnier swissprot:YEHM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEHM_ECOLI helixturnhelix swissprot:YEHM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEHM_ECOLI hmoment swissprot:YEHM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEHM_ECOLI iep swissprot:YEHM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEHM_ECOLI inforesidue swissprot:YEHM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEHM_ECOLI octanol swissprot:YEHM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEHM_ECOLI pepcoil swissprot:YEHM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEHM_ECOLI pepdigest swissprot:YEHM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEHM_ECOLI pepinfo swissprot:YEHM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEHM_ECOLI pepnet swissprot:YEHM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEHM_ECOLI pepstats swissprot:YEHM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEHM_ECOLI pepwheel swissprot:YEHM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEHM_ECOLI pepwindow swissprot:YEHM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEHM_ECOLI sigcleave swissprot:YEHM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEHM_ECOLI ## Database ID URL or Descriptions # BioGrid 4262849 6 # EcoGene EG14248 ymfJ # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # IntAct P75973 5 # Organism YMFJ_ECOLI Escherichia coli (strain K12) # PIR E64859 E64859 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YMFJ_ECOLI Uncharacterized protein YmfJ # RefSeq NP_415662 NC_000913.3 # RefSeq WP_001005353 NZ_CP010440.1 # eggNOG ENOG4107712 Bacteria # eggNOG ENOG410ZF6G LUCA BLAST swissprot:YMFJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YMFJ_ECOLI BioCyc ECOL316407:JW1130-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1130-MONOMER BioCyc EcoCyc:G6588-MONOMER http://biocyc.org/getid?id=EcoCyc:G6588-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14248 http://www.ecogene.org/geneInfo.php?eg_id=EG14248 EnsemblBacteria AAC74228 http://www.ensemblgenomes.org/id/AAC74228 EnsemblBacteria AAC74228 http://www.ensemblgenomes.org/id/AAC74228 EnsemblBacteria BAE76379 http://www.ensemblgenomes.org/id/BAE76379 EnsemblBacteria BAE76379 http://www.ensemblgenomes.org/id/BAE76379 EnsemblBacteria BAE76379 http://www.ensemblgenomes.org/id/BAE76379 EnsemblBacteria b1144 http://www.ensemblgenomes.org/id/b1144 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GeneID 945718 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945718 IntAct P75973 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75973* KEGG_Gene ecj:JW1130 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1130 KEGG_Gene eco:b1144 http://www.genome.jp/dbget-bin/www_bget?eco:b1144 PSORT swissprot:YMFJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YMFJ_ECOLI PSORT-B swissprot:YMFJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YMFJ_ECOLI PSORT2 swissprot:YMFJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YMFJ_ECOLI Phobius swissprot:YMFJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YMFJ_ECOLI ProteinModelPortal P75973 http://www.proteinmodelportal.org/query/uniprot/P75973 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415662 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415662 RefSeq WP_001005353 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001005353 SMR P75973 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75973 STRING 511145.b1144 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1144&targetmode=cogs UniProtKB YMFJ_ECOLI http://www.uniprot.org/uniprot/YMFJ_ECOLI UniProtKB-AC P75973 http://www.uniprot.org/uniprot/P75973 charge swissprot:YMFJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YMFJ_ECOLI eggNOG ENOG4107712 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107712 eggNOG ENOG410ZF6G http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZF6G epestfind swissprot:YMFJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YMFJ_ECOLI garnier swissprot:YMFJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YMFJ_ECOLI helixturnhelix swissprot:YMFJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YMFJ_ECOLI hmoment swissprot:YMFJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YMFJ_ECOLI iep swissprot:YMFJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YMFJ_ECOLI inforesidue swissprot:YMFJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YMFJ_ECOLI octanol swissprot:YMFJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YMFJ_ECOLI pepcoil swissprot:YMFJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YMFJ_ECOLI pepdigest swissprot:YMFJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YMFJ_ECOLI pepinfo swissprot:YMFJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YMFJ_ECOLI pepnet swissprot:YMFJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YMFJ_ECOLI pepstats swissprot:YMFJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YMFJ_ECOLI pepwheel swissprot:YMFJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YMFJ_ECOLI pepwindow swissprot:YMFJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YMFJ_ECOLI sigcleave swissprot:YMFJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YMFJ_ECOLI ## Database ID URL or Descriptions # AltName CYSH_ECOLI 3'-phosphoadenylylsulfate reductase # AltName CYSH_ECOLI PAPS reductase, thioredoxin dependent # AltName CYSH_ECOLI PAPS sulfotransferase # AltName CYSH_ECOLI PAdoPS reductase # BRENDA 1.8.4 2026 # BioGrid 4261451 22 # CATALYTIC ACTIVITY CYSH_ECOLI Adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide = 3'-phosphoadenylyl sulfate + thioredoxin. # CDD cd01713 PAPS_reductase # EcoGene EG10189 cysH # FUNCTION CYSH_ECOLI Reduction of activated sulfate into sulfite. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0004604 phosphoadenylyl-sulfate reductase (thioredoxin) activity; IDA:EcoCyc. # GO_process GO:0006790 sulfur compound metabolic process; IDA:EcoCyc. # GO_process GO:0019379 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin); IDA:EcoCyc. # GO_process GO:0070814 hydrogen sulfide biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.620 -; 1. # HAMAP MF_00063 CysH # IntAct P17854 4 # InterPro IPR002500 PAPS_reduct # InterPro IPR004511 PAPS/APS_Rdtase # InterPro IPR011800 PAPS_reductase_CysH # InterPro IPR014729 Rossmann-like_a/b/a_fold # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00920 Sulfur metabolism # Organism CYSH_ECOLI Escherichia coli (strain K12) # PATHWAY Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate step 3/3. # PATRIC 32120936 VBIEscCol129921_2860 # PDB 1SUR X-ray; 2.00 A; A=2-216 # PDB 2O8V X-ray; 3.00 A; A=1-244 # PIR S14221 RDECPA # PIRSF PIRSF000857 PAPS_reductase # Pfam PF01507 PAPS_reduct # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CYSH_ECOLI Phosphoadenosine phosphosulfate reductase # RefSeq NP_417242 NC_000913.3 # RefSeq WP_000039850 NZ_LN832404.1 # SIMILARITY Belongs to the PAPS reductase family. CysH subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION CYSH_ECOLI Cytoplasm. # SUBUNIT CYSH_ECOLI Homodimer. # TIGRFAMs TIGR00434 cysH # TIGRFAMs TIGR02057 PAPS_reductase # UniPathway UPA00140 UER00206 # eggNOG COG0175 LUCA # eggNOG ENOG4105ET3 Bacteria BLAST swissprot:CYSH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CYSH_ECOLI BioCyc ECOL316407:JW2732-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2732-MONOMER BioCyc EcoCyc:PAPSSULFOTRANS-MONOMER http://biocyc.org/getid?id=EcoCyc:PAPSSULFOTRANS-MONOMER BioCyc MetaCyc:PAPSSULFOTRANS-MONOMER http://biocyc.org/getid?id=MetaCyc:PAPSSULFOTRANS-MONOMER COG COG0175 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0175 DOI 10.1007/BF00269864 http://dx.doi.org/10.1007/BF00269864 DOI 10.1016/0014-5793(90)80052-K http://dx.doi.org/10.1016/0014-5793(90)80052-K DOI 10.1016/S0969-2126(97)00244-X http://dx.doi.org/10.1016/S0969-2126(97)00244-X DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1432-1033.1995.347_1.x http://dx.doi.org/10.1111/j.1432-1033.1995.347_1.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.8.4.8 http://www.genome.jp/dbget-bin/www_bget?EC:1.8.4.8 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M23008 http://www.ebi.ac.uk/ena/data/view/M23008 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EMBL Y07525 http://www.ebi.ac.uk/ena/data/view/Y07525 ENZYME 1.8.4.8 http://enzyme.expasy.org/EC/1.8.4.8 EchoBASE EB0186 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0186 EcoGene EG10189 http://www.ecogene.org/geneInfo.php?eg_id=EG10189 EnsemblBacteria AAC75804 http://www.ensemblgenomes.org/id/AAC75804 EnsemblBacteria AAC75804 http://www.ensemblgenomes.org/id/AAC75804 EnsemblBacteria BAE76839 http://www.ensemblgenomes.org/id/BAE76839 EnsemblBacteria BAE76839 http://www.ensemblgenomes.org/id/BAE76839 EnsemblBacteria BAE76839 http://www.ensemblgenomes.org/id/BAE76839 EnsemblBacteria b2762 http://www.ensemblgenomes.org/id/b2762 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004604 GO_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GO_process GO:0019379 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019379 GO_process GO:0070814 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070814 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 GeneID 947230 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947230 HAMAP MF_00063 http://hamap.expasy.org/unirule/MF_00063 HOGENOM HOG000249396 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000249396&db=HOGENOM6 InParanoid P17854 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P17854 IntAct P17854 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P17854* IntEnz 1.8.4.8 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.8.4.8 InterPro IPR002500 http://www.ebi.ac.uk/interpro/entry/IPR002500 InterPro IPR004511 http://www.ebi.ac.uk/interpro/entry/IPR004511 InterPro IPR011800 http://www.ebi.ac.uk/interpro/entry/IPR011800 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2732 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2732 KEGG_Gene eco:b2762 http://www.genome.jp/dbget-bin/www_bget?eco:b2762 KEGG_Orthology KO:K00390 http://www.genome.jp/dbget-bin/www_bget?KO:K00390 KEGG_Pathway ko00920 http://www.genome.jp/kegg-bin/show_pathway?ko00920 KEGG_Reaction rn:R02021 http://www.genome.jp/dbget-bin/www_bget?rn:R02021 OMA PRNKLLD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PRNKLLD PDB 1SUR http://www.ebi.ac.uk/pdbe-srv/view/entry/1SUR PDB 2O8V http://www.ebi.ac.uk/pdbe-srv/view/entry/2O8V PDBsum 1SUR http://www.ebi.ac.uk/pdbsum/1SUR PDBsum 2O8V http://www.ebi.ac.uk/pdbsum/2O8V PSORT swissprot:CYSH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CYSH_ECOLI PSORT-B swissprot:CYSH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CYSH_ECOLI PSORT2 swissprot:CYSH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CYSH_ECOLI Pfam PF01507 http://pfam.xfam.org/family/PF01507 Phobius swissprot:CYSH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CYSH_ECOLI PhylomeDB P17854 http://phylomedb.org/?seqid=P17854 ProteinModelPortal P17854 http://www.proteinmodelportal.org/query/uniprot/P17854 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2005873 http://www.ncbi.nlm.nih.gov/pubmed/2005873 PubMed 2404794 http://www.ncbi.nlm.nih.gov/pubmed/2404794 PubMed 2670946 http://www.ncbi.nlm.nih.gov/pubmed/2670946 PubMed 7588765 http://www.ncbi.nlm.nih.gov/pubmed/7588765 PubMed 9261082 http://www.ncbi.nlm.nih.gov/pubmed/9261082 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417242 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417242 RefSeq WP_000039850 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000039850 SMR P17854 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P17854 STRING 511145.b2762 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2762&targetmode=cogs STRING COG0175 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0175&targetmode=cogs TIGRFAMs TIGR00434 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00434 TIGRFAMs TIGR02057 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02057 UniProtKB CYSH_ECOLI http://www.uniprot.org/uniprot/CYSH_ECOLI UniProtKB-AC P17854 http://www.uniprot.org/uniprot/P17854 charge swissprot:CYSH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CYSH_ECOLI eggNOG COG0175 http://eggnogapi.embl.de/nog_data/html/tree/COG0175 eggNOG ENOG4105ET3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ET3 epestfind swissprot:CYSH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CYSH_ECOLI garnier swissprot:CYSH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CYSH_ECOLI helixturnhelix swissprot:CYSH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CYSH_ECOLI hmoment swissprot:CYSH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CYSH_ECOLI iep swissprot:CYSH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CYSH_ECOLI inforesidue swissprot:CYSH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CYSH_ECOLI octanol swissprot:CYSH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CYSH_ECOLI pepcoil swissprot:CYSH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CYSH_ECOLI pepdigest swissprot:CYSH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CYSH_ECOLI pepinfo swissprot:CYSH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CYSH_ECOLI pepnet swissprot:CYSH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CYSH_ECOLI pepstats swissprot:CYSH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CYSH_ECOLI pepwheel swissprot:CYSH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CYSH_ECOLI pepwindow swissprot:CYSH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CYSH_ECOLI sigcleave swissprot:CYSH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CYSH_ECOLI ## Database ID URL or Descriptions # BioGrid 4259940 9 # EcoGene EG12359 ybgD # GO_component GO:0009289 pilus; IEA:UniProtKB-SubCell. # GO_process GO:0007155 cell adhesion; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0007155 cell adhesion # Gene3D 2.60.40.1090 -; 1. # INTERACTION YBGD_ECOLI P75680 insO1; NbExp=2; IntAct=EBI-1119998, EBI-9152908; # IntAct P37909 26 # InterPro IPR000259 Adhesion_dom_fimbrial # InterPro IPR008966 Adhesion_dom # Organism YBGD_ECOLI Escherichia coli (strain K12) # PATRIC 32116633 VBIEscCol129921_0749 # PIR F64807 F64807 # Pfam PF00419 Fimbrial # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBGD_ECOLI Uncharacterized fimbrial-like protein YbgD # RefSeq NP_415247 NC_000913.3 # RefSeq WP_000472412 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=J01619; Type=Frameshift; Positions=98; Evidence={ECO 0000305}; # SIMILARITY Belongs to the fimbrial protein family. {ECO 0000305}. # SUBCELLULAR LOCATION YBGD_ECOLI Fimbrium {ECO 0000305}. # SUPFAM SSF49401 SSF49401 # eggNOG ENOG4106UBK Bacteria # eggNOG ENOG410YS65 LUCA BLAST swissprot:YBGD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBGD_ECOLI BioCyc ECOL316407:JW0709-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0709-MONOMER BioCyc EcoCyc:EG12359-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12359-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01619 http://www.ebi.ac.uk/ena/data/view/J01619 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2262 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2262 EcoGene EG12359 http://www.ecogene.org/geneInfo.php?eg_id=EG12359 EnsemblBacteria AAC73813 http://www.ensemblgenomes.org/id/AAC73813 EnsemblBacteria AAC73813 http://www.ensemblgenomes.org/id/AAC73813 EnsemblBacteria BAA35383 http://www.ensemblgenomes.org/id/BAA35383 EnsemblBacteria BAA35383 http://www.ensemblgenomes.org/id/BAA35383 EnsemblBacteria BAA35383 http://www.ensemblgenomes.org/id/BAA35383 EnsemblBacteria b0719 http://www.ensemblgenomes.org/id/b0719 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009289 GO_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 Gene3D 2.60.40.1090 http://www.cathdb.info/version/latest/superfamily/2.60.40.1090 GeneID 945325 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945325 HOGENOM HOG000260127 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260127&db=HOGENOM6 InParanoid P37909 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37909 IntAct P37909 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37909* InterPro IPR000259 http://www.ebi.ac.uk/interpro/entry/IPR000259 InterPro IPR008966 http://www.ebi.ac.uk/interpro/entry/IPR008966 KEGG_Gene ecj:JW0709 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0709 KEGG_Gene eco:b0719 http://www.genome.jp/dbget-bin/www_bget?eco:b0719 OMA DINLENC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DINLENC PSORT swissprot:YBGD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBGD_ECOLI PSORT-B swissprot:YBGD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBGD_ECOLI PSORT2 swissprot:YBGD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBGD_ECOLI Pfam PF00419 http://pfam.xfam.org/family/PF00419 Phobius swissprot:YBGD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBGD_ECOLI PhylomeDB P37909 http://phylomedb.org/?seqid=P37909 ProteinModelPortal P37909 http://www.proteinmodelportal.org/query/uniprot/P37909 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415247 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415247 RefSeq WP_000472412 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000472412 SMR P37909 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37909 STRING 511145.b0719 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0719&targetmode=cogs SUPFAM SSF49401 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49401 UniProtKB YBGD_ECOLI http://www.uniprot.org/uniprot/YBGD_ECOLI UniProtKB-AC P37909 http://www.uniprot.org/uniprot/P37909 charge swissprot:YBGD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBGD_ECOLI eggNOG ENOG4106UBK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106UBK eggNOG ENOG410YS65 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YS65 epestfind swissprot:YBGD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBGD_ECOLI garnier swissprot:YBGD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBGD_ECOLI helixturnhelix swissprot:YBGD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBGD_ECOLI hmoment swissprot:YBGD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBGD_ECOLI iep swissprot:YBGD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBGD_ECOLI inforesidue swissprot:YBGD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBGD_ECOLI octanol swissprot:YBGD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBGD_ECOLI pepcoil swissprot:YBGD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBGD_ECOLI pepdigest swissprot:YBGD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBGD_ECOLI pepinfo swissprot:YBGD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBGD_ECOLI pepnet swissprot:YBGD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBGD_ECOLI pepstats swissprot:YBGD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBGD_ECOLI pepwheel swissprot:YBGD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBGD_ECOLI pepwindow swissprot:YBGD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBGD_ECOLI sigcleave swissprot:YBGD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBGD_ECOLI ## Database ID URL or Descriptions # BioGrid 4261673 9 # CDD cd06261 TM_PBP2 # EcoGene EG10750 potB # FUNCTION POTB_ECOLI Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IDA:EcoCyc. # GO_function GO:0015417 polyamine-transporting ATPase activity; IMP:EcoCyc. # GO_process GO:0015846 polyamine transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # Gene3D 1.10.3720.10 -; 1. # InterPro IPR000515 MetI-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00299 Spermidine/putrescine transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism POTB_ECOLI Escherichia coli (strain K12) # PATRIC 32117497 VBIEscCol129921_1171 # PIR B40840 B40840 # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName POTB_ECOLI Spermidine/putrescine transport system permease protein PotB # RefSeq NP_415643 NC_000913.3 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION POTB_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF161098 SSF161098 # TCDB 3.A.1.11 the atp-binding cassette (abc) superfamily # eggNOG COG1176 LUCA # eggNOG ENOG4105F38 Bacteria BLAST swissprot:POTB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:POTB_ECOLI BioCyc ECOL316407:JW1111-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1111-MONOMER BioCyc EcoCyc:POTB-MONOMER http://biocyc.org/getid?id=EcoCyc:POTB-MONOMER BioCyc MetaCyc:POTB-MONOMER http://biocyc.org/getid?id=MetaCyc:POTB-MONOMER COG COG1176 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1176 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M64519 http://www.ebi.ac.uk/ena/data/view/M64519 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0743 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0743 EcoGene EG10750 http://www.ecogene.org/geneInfo.php?eg_id=EG10750 EnsemblBacteria AAC74209 http://www.ensemblgenomes.org/id/AAC74209 EnsemblBacteria AAC74209 http://www.ensemblgenomes.org/id/AAC74209 EnsemblBacteria BAA35945 http://www.ensemblgenomes.org/id/BAA35945 EnsemblBacteria BAA35945 http://www.ensemblgenomes.org/id/BAA35945 EnsemblBacteria BAA35945 http://www.ensemblgenomes.org/id/BAA35945 EnsemblBacteria b1125 http://www.ensemblgenomes.org/id/b1125 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015417 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015417 GO_process GO:0015846 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015846 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 945692 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945692 HOGENOM HOG000263581 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000263581&db=HOGENOM6 InParanoid P0AFK4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFK4 InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1111 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1111 KEGG_Gene eco:b1125 http://www.genome.jp/dbget-bin/www_bget?eco:b1125 KEGG_Orthology KO:K11071 http://www.genome.jp/dbget-bin/www_bget?KO:K11071 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA QDWGMGA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QDWGMGA PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:POTB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:POTB_ECOLI PSORT-B swissprot:POTB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:POTB_ECOLI PSORT2 swissprot:POTB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:POTB_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Phobius swissprot:POTB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:POTB_ECOLI PhylomeDB P0AFK4 http://phylomedb.org/?seqid=P0AFK4 ProteinModelPortal P0AFK4 http://www.proteinmodelportal.org/query/uniprot/P0AFK4 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1939142 http://www.ncbi.nlm.nih.gov/pubmed/1939142 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415643 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415643 STRING 511145.b1125 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1125&targetmode=cogs STRING COG1176 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1176&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.11 http://www.tcdb.org/search/result.php?tc=3.A.1.11 UniProtKB POTB_ECOLI http://www.uniprot.org/uniprot/POTB_ECOLI UniProtKB-AC P0AFK4 http://www.uniprot.org/uniprot/P0AFK4 charge swissprot:POTB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:POTB_ECOLI eggNOG COG1176 http://eggnogapi.embl.de/nog_data/html/tree/COG1176 eggNOG ENOG4105F38 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F38 epestfind swissprot:POTB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:POTB_ECOLI garnier swissprot:POTB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:POTB_ECOLI helixturnhelix swissprot:POTB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:POTB_ECOLI hmoment swissprot:POTB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:POTB_ECOLI iep swissprot:POTB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:POTB_ECOLI inforesidue swissprot:POTB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:POTB_ECOLI octanol swissprot:POTB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:POTB_ECOLI pepcoil swissprot:POTB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:POTB_ECOLI pepdigest swissprot:POTB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:POTB_ECOLI pepinfo swissprot:POTB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:POTB_ECOLI pepnet swissprot:POTB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:POTB_ECOLI pepstats swissprot:POTB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:POTB_ECOLI pepwheel swissprot:POTB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:POTB_ECOLI pepwindow swissprot:POTB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:POTB_ECOLI sigcleave swissprot:POTB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:POTB_ECOLI ## Database ID URL or Descriptions # FUNCTION PIFC_ECOLI Transcription repression of its own gene by binding to the PIF operator (pifO) and replication initiation from the primary origin (ori-1). Transcriptional repressor of the pifA and pifB. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # MISCELLANEOUS PIFC_ECOLI C protein has a much higher affinity for pifO than for ori-1. # MISCELLANEOUS PIFC_ECOLI C protein, like p22 proteins, contains a number of alpha-helical regions and these may be involved in forming a pattern of non-covalent contacts with DNA which is different from that formed by most DNA-binding proteins. # Organism PIFC_ECOLI Escherichia coli (strain K12) # PIR A24710 A24710 # RecName PIFC_ECOLI Transcriptional repressor PifC # RefSeq NP_061420 NC_002483.1 # RefSeq WP_000952217 NZ_CP014273.1 # SEQUENCE CAUTION Sequence=AAA24897.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA97911.1; Type=Erroneous initiation; Evidence={ECO 0000305}; Sequence=CAA25877.1; Type=Erroneous initiation; Evidence={ECO:0000305}; BLAST swissprot:PIFC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PIFC_ECOLI DOI 10.1016/S0022-2836(84)80004-2 http://dx.doi.org/10.1016/S0022-2836(84)80004-2 DOI 10.1093/nar/14.24.9699 http://dx.doi.org/10.1093/nar/14.24.9699 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL M12987 http://www.ebi.ac.uk/ena/data/view/M12987 EMBL X01740 http://www.ebi.ac.uk/ena/data/view/X01740 EMBL X04968 http://www.ebi.ac.uk/ena/data/view/X04968 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 1263560 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263560 OMA AGRENTS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AGRENTS PSORT swissprot:PIFC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PIFC_ECOLI PSORT-B swissprot:PIFC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PIFC_ECOLI PSORT2 swissprot:PIFC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PIFC_ECOLI Phobius swissprot:PIFC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PIFC_ECOLI ProteinModelPortal P10030 http://www.proteinmodelportal.org/query/uniprot/P10030 PubMed 3027660 http://www.ncbi.nlm.nih.gov/pubmed/3027660 PubMed 6096563 http://www.ncbi.nlm.nih.gov/pubmed/6096563 PubMed 6413493 http://www.ncbi.nlm.nih.gov/pubmed/6413493 RefSeq NP_061420 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061420 RefSeq WP_000952217 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000952217 SMR P10030 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P10030 UniProtKB PIFC_ECOLI http://www.uniprot.org/uniprot/PIFC_ECOLI UniProtKB-AC P10030 http://www.uniprot.org/uniprot/P10030 charge swissprot:PIFC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PIFC_ECOLI epestfind swissprot:PIFC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PIFC_ECOLI garnier swissprot:PIFC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PIFC_ECOLI helixturnhelix swissprot:PIFC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PIFC_ECOLI hmoment swissprot:PIFC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PIFC_ECOLI iep swissprot:PIFC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PIFC_ECOLI inforesidue swissprot:PIFC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PIFC_ECOLI octanol swissprot:PIFC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PIFC_ECOLI pepcoil swissprot:PIFC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PIFC_ECOLI pepdigest swissprot:PIFC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PIFC_ECOLI pepinfo swissprot:PIFC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PIFC_ECOLI pepnet swissprot:PIFC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PIFC_ECOLI pepstats swissprot:PIFC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PIFC_ECOLI pepwheel swissprot:PIFC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PIFC_ECOLI pepwindow swissprot:PIFC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PIFC_ECOLI sigcleave swissprot:PIFC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PIFC_ECOLI ## Database ID URL or Descriptions # EcoGene EG10878 rplQ # FUNCTION RL17_ECOLI Requires L15 for assembly into the 50S subunit. {ECO 0000269|PubMed 3298242}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0022625 cytosolic large ribosomal subunit; IDA:EcoCyc. # GO_function GO:0003735 structural constituent of ribosome; IBA:GO_Central. # GO_process GO:0006412 translation; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_process GO:0006412 translation # Gene3D 3.90.1030.10 -; 1. # HAMAP MF_01368 Ribosomal_L17 # IntAct P0AG44 135 # InterPro IPR000456 Ribosomal_L17 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=14364.7; Method=MALDI; Range=1-127; Evidence={ECO:0000269|PubMed 10094780}; # Organism RL17_ECOLI Escherichia coli (strain K12) # PANTHER PTHR14413 PTHR14413 # PATRIC 32122020 VBIEscCol129921_3387 # PDB 2J28 EM; 8.00 A; N=1-127 # PDB 2RDO EM; 9.10 A; N=1-127 # PDB 3BBX EM; 10.00 A; N=1-127 # PDB 3J5L EM; 6.60 A; N=1-120 # PDB 3J7Z EM; 3.90 A; N=1-127 # PDB 3J8G EM; 5.00 A; N=1-127 # PDB 3J9Y EM; 3.90 A; N=1-127 # PDB 3J9Z EM; 3.60 A; LJ=1-127 # PDB 3JA1 EM; 3.60 A; LP=1-127 # PDB 3JBU EM; 3.64 A; n=1-127 # PDB 3JBV EM; 3.32 A; n=1-127 # PDB 3JCD EM; 3.70 A; N=1-127 # PDB 3JCE EM; 3.20 A; N=1-127 # PDB 3JCJ EM; 3.70 A; M=1-127 # PDB 3JCN EM; 4.60 A; N=1-127 # PDB 4CSU EM; 5.50 A; N=1-127 # PDB 4U1U X-ray; 2.95 A; BN/DN=1-120 # PDB 4U1V X-ray; 3.00 A; BN/DN=1-120 # PDB 4U20 X-ray; 2.90 A; BN/DN=1-120 # PDB 4U24 X-ray; 2.90 A; BN/DN=1-120 # PDB 4U25 X-ray; 2.90 A; BN/DN=1-120 # PDB 4U26 X-ray; 2.80 A; BN/DN=1-120 # PDB 4U27 X-ray; 2.80 A; BN/DN=1-120 # PDB 4UY8 EM; 3.80 A; N=1-120 # PDB 4V47 EM; 12.30 A; AL=1-127 # PDB 4V48 EM; 11.50 A; AL=1-127 # PDB 4V4H X-ray; 3.46 A; BN/DN=1-127 # PDB 4V4Q X-ray; 3.46 A; BN/DN=1-127 # PDB 4V4V EM; 15.00 A; BL=3-116 # PDB 4V4W EM; 15.00 A; BL=3-116 # PDB 4V50 X-ray; 3.22 A; BN/DN=1-127 # PDB 4V52 X-ray; 3.21 A; BN/DN=1-127 # PDB 4V53 X-ray; 3.54 A; BN/DN=1-127 # PDB 4V54 X-ray; 3.30 A; BN/DN=1-127 # PDB 4V55 X-ray; 4.00 A; BN/DN=1-127 # PDB 4V56 X-ray; 3.93 A; BN/DN=1-127 # PDB 4V57 X-ray; 3.50 A; BN/DN=1-127 # PDB 4V5B X-ray; 3.74 A; AN/CN=1-127 # PDB 4V5H EM; 5.80 A; BN=1-120 # PDB 4V5Y X-ray; 4.45 A; BN/DN=1-127 # PDB 4V64 X-ray; 3.50 A; BN/DN=1-127 # PDB 4V65 EM; 9.00 A; BG=1-127 # PDB 4V66 EM; 9.00 A; BG=1-127 # PDB 4V69 EM; 6.70 A; BN=1-120 # PDB 4V6C X-ray; 3.19 A; BN/DN=1-127 # PDB 4V6D X-ray; 3.81 A; BN/DN=1-127 # PDB 4V6E X-ray; 3.71 A; BN/DN=1-127 # PDB 4V6K EM; 8.25 A; AO=1-127 # PDB 4V6L EM; 13.20 A; BO=1-127 # PDB 4V6M EM; 7.10 A; BN=1-127 # PDB 4V6N EM; 12.10 A; AP=1-127 # PDB 4V6O EM; 14.70 A; BP=1-127 # PDB 4V6P EM; 13.50 A; BP=1-127 # PDB 4V6Q EM; 11.50 A; BP=1-127 # PDB 4V6R EM; 11.50 A; BP=1-127 # PDB 4V6S EM; 13.10 A; AP=1-127 # PDB 4V6T EM; 8.30 A; BN=1-120 # PDB 4V6V EM; 9.80 A; BR=1-127 # PDB 4V6Y EM; 12.00 A; BN=1-120 # PDB 4V6Z EM; 12.00 A; BN=1-120 # PDB 4V70 EM; 17.00 A; BN=1-120 # PDB 4V71 EM; 20.00 A; BN=1-120 # PDB 4V72 EM; 13.00 A; BN=1-120 # PDB 4V73 EM; 15.00 A; BN=1-120 # PDB 4V74 EM; 17.00 A; BN=1-120 # PDB 4V75 EM; 12.00 A; BN=1-120 # PDB 4V76 EM; 17.00 A; BN=1-120 # PDB 4V77 EM; 17.00 A; BN=1-120 # PDB 4V78 EM; 20.00 A; BN=1-120 # PDB 4V79 EM; 15.00 A; BN=1-120 # PDB 4V7A EM; 9.00 A; BN=1-120 # PDB 4V7B EM; 6.80 A; BN=1-127 # PDB 4V7C EM; 7.60 A; BP=1-127 # PDB 4V7D EM; 7.60 A; AQ=1-127 # PDB 4V7I EM; 9.60 A; AN=1-127 # PDB 4V7S X-ray; 3.25 A; BN/DN=1-120 # PDB 4V7T X-ray; 3.19 A; BN/DN=1-120 # PDB 4V7U X-ray; 3.10 A; BN/DN=1-120 # PDB 4V7V X-ray; 3.29 A; BN/DN=1-120 # PDB 4V85 X-ray; 3.20 A; R=1-127 # PDB 4V89 X-ray; 3.70 A; BR=1-127 # PDB 4V9C X-ray; 3.30 A; BN/DN=1-127 # PDB 4V9D X-ray; 3.00 A; CN/DN=1-120 # PDB 4V9O X-ray; 2.90 A; AN/CN/EN/GN=1-127 # PDB 4V9P X-ray; 2.90 A; AN/CN/EN/GN=1-127 # PDB 4WF1 X-ray; 3.09 A; BN/DN=1-120 # PDB 4WOI X-ray; 3.00 A; BN/CN=1-127 # PDB 4WWW X-ray; 3.10 A; RN/YN=1-120 # PDB 4YBB X-ray; 2.10 A; CO/DO=1-125 # PDB 5ADY EM; 4.50 A; N=1-127 # PDB 5AFI EM; 2.90 A; N=1-127 # PDB 5AKA EM; 5.70 A; N=1-127 # PDB 5GAD EM; 3.70 A; O=1-127 # PDB 5GAE EM; 3.33 A; O=1-127 # PDB 5GAF EM; 4.30 A; O=1-125 # PDB 5GAG EM; 3.80 A; O=1-127 # PDB 5GAH EM; 3.80 A; O=1-127 # PDB 5IQR EM; 3.00 A; N=1-127 # PDB 5IT8 X-ray; 3.12 A; CO/DO=1-125 # PDB 5J5B X-ray; 2.80 A; CO/DO=1-125 # PDB 5J7L X-ray; 3.00 A; CO/DO=1-125 # PDB 5J88 X-ray; 3.32 A; CO/DO=1-127 # PDB 5J8A X-ray; 3.10 A; CO/DO=1-125 # PDB 5J91 X-ray; 2.96 A; CO/DO=1-125 # PDB 5JC9 X-ray; 3.03 A; CO/DO=1-125 # PDB 5JTE EM; 3.60 A; BN=1-127 # PDB 5JU8 EM; 3.60 A; BN=1-127 # PDB 5KCR EM; 3.60 A; 1R=1-127 # PDB 5KCS EM; 3.90 A; 1R=1-127 # PDB 5KPS EM; 3.90 A; N=1-127 # PDB 5KPV EM; 4.10 A; M=1-127 # PDB 5KPW EM; 3.90 A; M=1-127 # PDB 5KPX EM; 3.90 A; M=1-127 # PDB 5L3P EM; 3.70 A; R=1-127 # PIR B22884 R5EC17 # PROSITE PS01167 RIBOSOMAL_L17 # Pfam PF01196 Ribosomal_L17 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 50S ribosomal protein L17 {ECO:0000255|HAMAP-Rule MF_01368} # RefSeq NP_417753 NC_000913.3 # RefSeq WP_001216368 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein L17P family. {ECO:0000255|HAMAP-Rule MF_01368}. # SUBUNIT Part of the 50S ribosomal subunit. Contacts protein L32. {ECO:0000269|PubMed 2665813}. # SUPFAM SSF64263 SSF64263 # TIGRFAMs TIGR00059 L17 # eggNOG COG0203 LUCA # eggNOG ENOG4108ZT0 Bacteria BLAST swissprot:RL17_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RL17_ECOLI BioCyc ECOL316407:JW3256-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3256-MONOMER BioCyc EcoCyc:EG10878-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10878-MONOMER BioCyc MetaCyc:EG10878-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10878-MONOMER COG COG0203 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0203 DIP DIP-35801N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35801N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1016/S0092-8674(03)00427-6 http://dx.doi.org/10.1016/S0092-8674(03)00427-6 DOI 10.1016/j.celrep.2014.09.011 http://dx.doi.org/10.1016/j.celrep.2014.09.011 DOI 10.1021/bi00435a071 http://dx.doi.org/10.1021/bi00435a071 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/12.14.5813 http://dx.doi.org/10.1093/nar/12.14.5813 DOI 10.1093/nar/13.11.3891 http://dx.doi.org/10.1093/nar/13.11.3891 DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pbio.1001866 http://dx.doi.org/10.1371/journal.pbio.1001866 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01685 http://www.ebi.ac.uk/ena/data/view/J01685 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X00766 http://www.ebi.ac.uk/ena/data/view/X00766 EMBL X02543 http://www.ebi.ac.uk/ena/data/view/X02543 EchoBASE EB0871 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0871 EcoGene EG10878 http://www.ecogene.org/geneInfo.php?eg_id=EG10878 EnsemblBacteria AAC76319 http://www.ensemblgenomes.org/id/AAC76319 EnsemblBacteria AAC76319 http://www.ensemblgenomes.org/id/AAC76319 EnsemblBacteria BAE77997 http://www.ensemblgenomes.org/id/BAE77997 EnsemblBacteria BAE77997 http://www.ensemblgenomes.org/id/BAE77997 EnsemblBacteria BAE77997 http://www.ensemblgenomes.org/id/BAE77997 EnsemblBacteria b3294 http://www.ensemblgenomes.org/id/b3294 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0022625 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022625 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 Gene3D 3.90.1030.10 http://www.cathdb.info/version/latest/superfamily/3.90.1030.10 GeneID 947784 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947784 HAMAP MF_01368 http://hamap.expasy.org/unirule/MF_01368 HOGENOM HOG000019780 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000019780&db=HOGENOM6 InParanoid P0AG44 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AG44 IntAct P0AG44 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AG44* InterPro IPR000456 http://www.ebi.ac.uk/interpro/entry/IPR000456 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW3256 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3256 KEGG_Gene eco:b3294 http://www.genome.jp/dbget-bin/www_bget?eco:b3294 KEGG_Orthology KO:K02879 http://www.genome.jp/dbget-bin/www_bget?KO:K02879 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 MINT MINT-1251899 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1251899 OMA KYERITT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KYERITT PANTHER PTHR14413 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14413 PDB 2J28 http://www.ebi.ac.uk/pdbe-srv/view/entry/2J28 PDB 2RDO http://www.ebi.ac.uk/pdbe-srv/view/entry/2RDO PDB 3BBX http://www.ebi.ac.uk/pdbe-srv/view/entry/3BBX PDB 3J5L http://www.ebi.ac.uk/pdbe-srv/view/entry/3J5L PDB 3J7Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J7Z PDB 3J8G http://www.ebi.ac.uk/pdbe-srv/view/entry/3J8G PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 4CSU http://www.ebi.ac.uk/pdbe-srv/view/entry/4CSU PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4UY8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4UY8 PDB 4V47 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V47 PDB 4V48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V48 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5ADY http://www.ebi.ac.uk/pdbe-srv/view/entry/5ADY PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5AKA http://www.ebi.ac.uk/pdbe-srv/view/entry/5AKA PDB 5GAD http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAD PDB 5GAE http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAE PDB 5GAF http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAF PDB 5GAG http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAG PDB 5GAH http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAH PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 2J28 http://www.ebi.ac.uk/pdbsum/2J28 PDBsum 2RDO http://www.ebi.ac.uk/pdbsum/2RDO PDBsum 3BBX http://www.ebi.ac.uk/pdbsum/3BBX PDBsum 3J5L http://www.ebi.ac.uk/pdbsum/3J5L PDBsum 3J7Z http://www.ebi.ac.uk/pdbsum/3J7Z PDBsum 3J8G http://www.ebi.ac.uk/pdbsum/3J8G PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 4CSU http://www.ebi.ac.uk/pdbsum/4CSU PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4UY8 http://www.ebi.ac.uk/pdbsum/4UY8 PDBsum 4V47 http://www.ebi.ac.uk/pdbsum/4V47 PDBsum 4V48 http://www.ebi.ac.uk/pdbsum/4V48 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5ADY http://www.ebi.ac.uk/pdbsum/5ADY PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5AKA http://www.ebi.ac.uk/pdbsum/5AKA PDBsum 5GAD http://www.ebi.ac.uk/pdbsum/5GAD PDBsum 5GAE http://www.ebi.ac.uk/pdbsum/5GAE PDBsum 5GAF http://www.ebi.ac.uk/pdbsum/5GAF PDBsum 5GAG http://www.ebi.ac.uk/pdbsum/5GAG PDBsum 5GAH http://www.ebi.ac.uk/pdbsum/5GAH PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PROSITE PS01167 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01167 PSORT swissprot:RL17_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RL17_ECOLI PSORT-B swissprot:RL17_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RL17_ECOLI PSORT2 swissprot:RL17_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RL17_ECOLI Pfam PF01196 http://pfam.xfam.org/family/PF01196 Phobius swissprot:RL17_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RL17_ECOLI PhylomeDB P0AG44 http://phylomedb.org/?seqid=P0AG44 ProteinModelPortal P0AG44 http://www.proteinmodelportal.org/query/uniprot/P0AG44 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 12809609 http://www.ncbi.nlm.nih.gov/pubmed/12809609 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 24844575 http://www.ncbi.nlm.nih.gov/pubmed/24844575 PubMed 25310980 http://www.ncbi.nlm.nih.gov/pubmed/25310980 PubMed 2665813 http://www.ncbi.nlm.nih.gov/pubmed/2665813 PubMed 2989779 http://www.ncbi.nlm.nih.gov/pubmed/2989779 PubMed 3298242 http://www.ncbi.nlm.nih.gov/pubmed/3298242 PubMed 6379605 http://www.ncbi.nlm.nih.gov/pubmed/6379605 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417753 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417753 RefSeq WP_001216368 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001216368 SMR P0AG44 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AG44 STRING 511145.b3294 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3294&targetmode=cogs STRING COG0203 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0203&targetmode=cogs SUPFAM SSF64263 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF64263 TIGRFAMs TIGR00059 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00059 UniProtKB RL17_ECOLI http://www.uniprot.org/uniprot/RL17_ECOLI UniProtKB-AC P0AG44 http://www.uniprot.org/uniprot/P0AG44 charge swissprot:RL17_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RL17_ECOLI eggNOG COG0203 http://eggnogapi.embl.de/nog_data/html/tree/COG0203 eggNOG ENOG4108ZT0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZT0 epestfind swissprot:RL17_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RL17_ECOLI garnier swissprot:RL17_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RL17_ECOLI helixturnhelix swissprot:RL17_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RL17_ECOLI hmoment swissprot:RL17_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RL17_ECOLI iep swissprot:RL17_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RL17_ECOLI inforesidue swissprot:RL17_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RL17_ECOLI octanol swissprot:RL17_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RL17_ECOLI pepcoil swissprot:RL17_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RL17_ECOLI pepdigest swissprot:RL17_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RL17_ECOLI pepinfo swissprot:RL17_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RL17_ECOLI pepnet swissprot:RL17_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RL17_ECOLI pepstats swissprot:RL17_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RL17_ECOLI pepwheel swissprot:RL17_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RL17_ECOLI pepwindow swissprot:RL17_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RL17_ECOLI sigcleave swissprot:RL17_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RL17_ECOLI ## Database ID URL or Descriptions # BioGrid 4260660 324 # EcoGene EG11425 rfaY # FUNCTION RFAY_ECOLI Catalyzes the phosphorylation of heptose(II) of the outer membrane lipopolysaccharide core. {ECO 0000250}. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016301 kinase activity; IMP:EcoCyc. # GO_process GO:0009244 lipopolysaccharide core region biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0016310 phosphorylation; IMP:EcoCyc. # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # IntAct P27240 10 # InterPro IPR009330 LipoPS_heptP_kinase # InterPro IPR011009 Kinase-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # KEGG_Pathway ko00540 Lipopolysaccharide biosynthesis # Organism RFAY_ECOLI Escherichia coli (strain K12) # PATHWAY RFAY_ECOLI Bacterial outer membrane biogenesis; LPS core biosynthesis. # PATRIC 32122737 VBIEscCol129921_3745 # PIR S47846 S47846 # Pfam PF06176 WaaY # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RFAY_ECOLI Lipopolysaccharide core heptose(II) kinase RfaY # RefSeq NP_418082 NC_000913.3 # RefSeq WP_000615254 NZ_LN832404.1 # SIMILARITY Belongs to the protein kinase superfamily. RfaY/WaaY family. {ECO 0000305}. # SUPFAM SSF56112 SSF56112; 2 # eggNOG ENOG4108PDR Bacteria # eggNOG ENOG4111F7R LUCA BLAST swissprot:RFAY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RFAY_ECOLI BioCyc ECOL316407:JW3600-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3600-MONOMER BioCyc EcoCyc:EG11425-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11425-MONOMER BioCyc MetaCyc:EG11425-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11425-MONOMER COG COG0515 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0515 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M95398 http://www.ebi.ac.uk/ena/data/view/M95398 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.- http://enzyme.expasy.org/EC/2.7.1.- EchoBASE EB1395 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1395 EcoGene EG11425 http://www.ecogene.org/geneInfo.php?eg_id=EG11425 EnsemblBacteria AAC76649 http://www.ensemblgenomes.org/id/AAC76649 EnsemblBacteria AAC76649 http://www.ensemblgenomes.org/id/AAC76649 EnsemblBacteria BAE77667 http://www.ensemblgenomes.org/id/BAE77667 EnsemblBacteria BAE77667 http://www.ensemblgenomes.org/id/BAE77667 EnsemblBacteria BAE77667 http://www.ensemblgenomes.org/id/BAE77667 EnsemblBacteria b3625 http://www.ensemblgenomes.org/id/b3625 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_process GO:0009244 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009244 GO_process GO:0016310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016310 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 948145 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948145 HOGENOM HOG000126191 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126191&db=HOGENOM6 InParanoid P27240 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P27240 IntAct P27240 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P27240* IntEnz 2.7.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1 InterPro IPR009330 http://www.ebi.ac.uk/interpro/entry/IPR009330 InterPro IPR011009 http://www.ebi.ac.uk/interpro/entry/IPR011009 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Gene ecj:JW3600 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3600 KEGG_Gene eco:b3625 http://www.genome.jp/dbget-bin/www_bget?eco:b3625 KEGG_Orthology KO:K02850 http://www.genome.jp/dbget-bin/www_bget?KO:K02850 KEGG_Pathway ko00540 http://www.genome.jp/kegg-bin/show_pathway?ko00540 OMA MIIEKKV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MIIEKKV PSORT swissprot:RFAY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RFAY_ECOLI PSORT-B swissprot:RFAY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RFAY_ECOLI PSORT2 swissprot:RFAY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RFAY_ECOLI Pfam PF06176 http://pfam.xfam.org/family/PF06176 Phobius swissprot:RFAY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RFAY_ECOLI PhylomeDB P27240 http://phylomedb.org/?seqid=P27240 ProteinModelPortal P27240 http://www.proteinmodelportal.org/query/uniprot/P27240 PubMed 1624462 http://www.ncbi.nlm.nih.gov/pubmed/1624462 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418082 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418082 RefSeq WP_000615254 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000615254 STRING 511145.b3625 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3625&targetmode=cogs STRING COG0515 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0515&targetmode=cogs SUPFAM SSF56112 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56112 UniProtKB RFAY_ECOLI http://www.uniprot.org/uniprot/RFAY_ECOLI UniProtKB-AC P27240 http://www.uniprot.org/uniprot/P27240 charge swissprot:RFAY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RFAY_ECOLI eggNOG ENOG4108PDR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108PDR eggNOG ENOG4111F7R http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111F7R epestfind swissprot:RFAY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RFAY_ECOLI garnier swissprot:RFAY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RFAY_ECOLI helixturnhelix swissprot:RFAY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RFAY_ECOLI hmoment swissprot:RFAY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RFAY_ECOLI iep swissprot:RFAY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RFAY_ECOLI inforesidue swissprot:RFAY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RFAY_ECOLI octanol swissprot:RFAY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RFAY_ECOLI pepcoil swissprot:RFAY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RFAY_ECOLI pepdigest swissprot:RFAY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RFAY_ECOLI pepinfo swissprot:RFAY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RFAY_ECOLI pepnet swissprot:RFAY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RFAY_ECOLI pepstats swissprot:RFAY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RFAY_ECOLI pepwheel swissprot:RFAY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RFAY_ECOLI pepwindow swissprot:RFAY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RFAY_ECOLI sigcleave swissprot:RFAY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RFAY_ECOLI ## Database ID URL or Descriptions # AltName YJIE_ECOLI Hypochlorite-response regulator protein YjiE # AltName YJIE_ECOLI Quorum-sensing regulator protein D # BioGrid 4261004 6 # DISRUPTION PHENOTYPE YJIE_ECOLI Controversial. Hypermotility, up-regulation of flagellar genes and up-regulation of flagellar protein FliC (PubMed 20494990). Decreased viability following HOCl stress; no effect on motility was seen in this study (PubMed 22223481). {ECO 0000269|PubMed 20494990, ECO 0000269|PubMed 22223481}. # EcoGene EG12566 yjiE # FUNCTION YJIE_ECOLI Protects cells from HOCl (hypochlorite) stress but not peroxide or diamide stress. Decreases the intracellular load of reactive oxygen species by up-regulating genes involved in methionine and cysteine biosynthesis and down-regulating Fur- regulated genes involved in iron acquisition. Has also been suggested to down-regulate expression of the flagellar regulon, decreasing motility, but this activity was not confirmed in a second study (PubMed 22223481). {ECO 0000269|PubMed 22223481}. # GO_function GO:0000976 transcription regulatory region sequence-specific DNA binding; IDA:EcoCyc. # GO_function GO:0001017 bacterial-type RNA polymerase regulatory region DNA binding; IDA:EcoCyc. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; ISS:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # INDUCTION YJIE_ECOLI Transcription increases throughout growth and is maximal during stationary phase. Is not up-regulated upon exposure to HOCl. {ECO 0000269|PubMed 20494990, ECO 0000269|PubMed 22223481}. # IntAct P39376 2 # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR005119 LysR_subst-bd # InterPro IPR011991 WHTH_DNA-bd_dom # Organism YJIE_ECOLI Escherichia coli (strain K12) # PATRIC 32124256 VBIEscCol129921_4471 # PIR S56552 S56552 # PRINTS PR00039 HTHLYSR # PROSITE PS50931 HTH_LYSR # Pfam PF00126 HTH_1 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJIE_ECOLI HTH-type transcriptional regulator YjiE # RefSeq NP_418747 NC_000913.3 # RefSeq WP_000340740 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lysR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00253}. # SUBUNIT Forms dimers, tetramers and possibly dodecameric complexes; oligomerization may be governed by cellular concentrations. DNA-binding seems to decrease oligomerization. {ECO:0000269|PubMed 22223481}. # SUPFAM SSF46785 SSF46785 # eggNOG ENOG4107YNJ Bacteria # eggNOG ENOG410XP86 LUCA BLAST swissprot:YJIE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJIE_ECOLI BioCyc ECOL316407:JW4290-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4290-MONOMER BioCyc EcoCyc:G7924-MONOMER http://biocyc.org/getid?id=EcoCyc:G7924-MONOMER DIP DIP-12633N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12633N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.270.8.4076 http://dx.doi.org/10.1074/jbc.270.8.4076 DOI 10.1074/jbc.M111.287219 http://dx.doi.org/10.1074/jbc.M111.287219 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00382-10 http://dx.doi.org/10.1128/JB.00382-10 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL U15029 http://www.ebi.ac.uk/ena/data/view/U15029 EchoBASE EB2454 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2454 EcoGene EG12566 http://www.ecogene.org/geneInfo.php?eg_id=EG12566 EnsemblBacteria AAC77283 http://www.ensemblgenomes.org/id/AAC77283 EnsemblBacteria AAC77283 http://www.ensemblgenomes.org/id/AAC77283 EnsemblBacteria BAE78320 http://www.ensemblgenomes.org/id/BAE78320 EnsemblBacteria BAE78320 http://www.ensemblgenomes.org/id/BAE78320 EnsemblBacteria BAE78320 http://www.ensemblgenomes.org/id/BAE78320 EnsemblBacteria b4327 http://www.ensemblgenomes.org/id/b4327 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000976 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000976 GO_function GO:0001017 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001017 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 948852 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948852 HOGENOM HOG000170696 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000170696&db=HOGENOM6 InParanoid P39376 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39376 IntAct P39376 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39376* InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW4290 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4290 KEGG_Gene eco:b4327 http://www.genome.jp/dbget-bin/www_bget?eco:b4327 OMA NLESKWL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NLESKWL PRINTS PR00039 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00039 PROSITE PS50931 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50931 PSORT swissprot:YJIE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJIE_ECOLI PSORT-B swissprot:YJIE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJIE_ECOLI PSORT2 swissprot:YJIE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJIE_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:YJIE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJIE_ECOLI PhylomeDB P39376 http://phylomedb.org/?seqid=P39376 ProteinModelPortal P39376 http://www.proteinmodelportal.org/query/uniprot/P39376 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20494990 http://www.ncbi.nlm.nih.gov/pubmed/20494990 PubMed 22223481 http://www.ncbi.nlm.nih.gov/pubmed/22223481 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 7876157 http://www.ncbi.nlm.nih.gov/pubmed/7876157 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418747 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418747 RefSeq WP_000340740 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000340740 SMR P39376 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39376 STRING 511145.b4327 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4327&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB YJIE_ECOLI http://www.uniprot.org/uniprot/YJIE_ECOLI UniProtKB-AC P39376 http://www.uniprot.org/uniprot/P39376 charge swissprot:YJIE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJIE_ECOLI eggNOG ENOG4107YNJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107YNJ eggNOG ENOG410XP86 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XP86 epestfind swissprot:YJIE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJIE_ECOLI garnier swissprot:YJIE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJIE_ECOLI helixturnhelix swissprot:YJIE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJIE_ECOLI hmoment swissprot:YJIE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJIE_ECOLI iep swissprot:YJIE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJIE_ECOLI inforesidue swissprot:YJIE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJIE_ECOLI octanol swissprot:YJIE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJIE_ECOLI pepcoil swissprot:YJIE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJIE_ECOLI pepdigest swissprot:YJIE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJIE_ECOLI pepinfo swissprot:YJIE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJIE_ECOLI pepnet swissprot:YJIE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJIE_ECOLI pepstats swissprot:YJIE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJIE_ECOLI pepwheel swissprot:YJIE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJIE_ECOLI pepwindow swissprot:YJIE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJIE_ECOLI sigcleave swissprot:YJIE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJIE_ECOLI ## Database ID URL or Descriptions # AltName DAPE_ECOLI N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=0.41 mM for L,L-SDAP (in the presence of Zn(2+) at pH 7.0) {ECO 0000269|PubMed:3276674}; # CATALYTIC ACTIVITY DAPE_ECOLI N-succinyl-LL-2,6-diaminoheptanedioate + H(2)O = succinate + LL-2,6-diaminoheptanedioate. # CDD cd03891 M20_DapE_proteobac # COFACTOR DAPE_ECOLI Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000269|PubMed 3276674}; Note=Binds 1 Co(2+) ion per subunit. {ECO 0000269|PubMed 3276674}; # COFACTOR DAPE_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 3276674}; Note=Binds 1 Zn(2+) ion per subunit. {ECO 0000269|PubMed 3276674}; # EcoGene EG10208 dapE # FUNCTION DAPE_ECOLI Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls. {ECO 0000269|PubMed 3276674}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008237 metallopeptidase activity; IEA:InterPro. # GO_function GO:0008270 zinc ion binding; IBA:GO_Central. # GO_function GO:0009014 succinyl-diaminopimelate desuccinylase activity; IMP:EcoliWiki. # GO_function GO:0050897 cobalt ion binding; IEA:UniProtKB-HAMAP. # GO_process GO:0009089 lysine biosynthetic process via diaminopimelate; IEA:UniProtKB-HAMAP. # GO_process GO:0019877 diaminopimelate biosynthetic process; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.30.70.360 -; 1. # HAMAP MF_01690 DapE # IntAct P0AED7 6 # InterPro IPR001261 ArgE/DapE_CS # InterPro IPR002933 Peptidase_M20 # InterPro IPR005941 DapE_proteobac # InterPro IPR011650 Peptidase_M20_dimer # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00300 Lysine biosynthesis # MISCELLANEOUS DAPE_ECOLI DapE/msgB is a multicopy suppressor of a temperature-sensitive allele of the heat shock gene grpE. # Organism DAPE_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route) step 3/3. # PATRIC 32120327 VBIEscCol129921_2566 # PIR A42959 A42959 # PROSITE PS00758 ARGE_DAPE_CPG2_1 # PROSITE PS00759 ARGE_DAPE_CPG2_2 # Pfam PF01546 Peptidase_M20 # Pfam PF07687 M20_dimer # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DAPE_ECOLI Succinyl-diaminopimelate desuccinylase # RefSeq NP_416967 NC_000913.3 # RefSeq WP_001277801 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase M20A family. DapE subfamily. {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 3276674}. # SUPFAM SSF55031 SSF55031 # TIGRFAMs TIGR01246 dapE_proteo # UniPathway UPA00034 UER00021 # eggNOG COG0624 LUCA # eggNOG ENOG4105C9Y Bacteria BLAST swissprot:DAPE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DAPE_ECOLI BioCyc ECOL316407:JW2456-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2456-MONOMER BioCyc EcoCyc:MONOMER0-1981 http://biocyc.org/getid?id=EcoCyc:MONOMER0-1981 BioCyc MetaCyc:MONOMER0-1981 http://biocyc.org/getid?id=MetaCyc:MONOMER0-1981 COG COG0624 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0624 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.5.1.18 http://www.genome.jp/dbget-bin/www_bget?EC:3.5.1.18 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL S41760 http://www.ebi.ac.uk/ena/data/view/S41760 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X57403 http://www.ebi.ac.uk/ena/data/view/X57403 ENZYME 3.5.1.18 http://enzyme.expasy.org/EC/3.5.1.18 EchoBASE EB0204 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0204 EcoGene EG10208 http://www.ecogene.org/geneInfo.php?eg_id=EG10208 EnsemblBacteria AAC75525 http://www.ensemblgenomes.org/id/AAC75525 EnsemblBacteria AAC75525 http://www.ensemblgenomes.org/id/AAC75525 EnsemblBacteria BAA16346 http://www.ensemblgenomes.org/id/BAA16346 EnsemblBacteria BAA16346 http://www.ensemblgenomes.org/id/BAA16346 EnsemblBacteria BAA16346 http://www.ensemblgenomes.org/id/BAA16346 EnsemblBacteria b2472 http://www.ensemblgenomes.org/id/b2472 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008237 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008237 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0009014 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009014 GO_function GO:0050897 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050897 GO_process GO:0009089 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009089 GO_process GO:0019877 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019877 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.30.70.360 http://www.cathdb.info/version/latest/superfamily/3.30.70.360 GeneID 948313 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948313 HAMAP MF_01690 http://hamap.expasy.org/unirule/MF_01690 HOGENOM HOG000243770 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000243770&db=HOGENOM6 InParanoid P0AED7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AED7 IntAct P0AED7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AED7* IntEnz 3.5.1.18 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.1.18 InterPro IPR001261 http://www.ebi.ac.uk/interpro/entry/IPR001261 InterPro IPR002933 http://www.ebi.ac.uk/interpro/entry/IPR002933 InterPro IPR005941 http://www.ebi.ac.uk/interpro/entry/IPR005941 InterPro IPR011650 http://www.ebi.ac.uk/interpro/entry/IPR011650 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2456 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2456 KEGG_Gene eco:b2472 http://www.genome.jp/dbget-bin/www_bget?eco:b2472 KEGG_Orthology KO:K01439 http://www.genome.jp/dbget-bin/www_bget?KO:K01439 KEGG_Pathway ko00300 http://www.genome.jp/kegg-bin/show_pathway?ko00300 KEGG_Reaction rn:R02734 http://www.genome.jp/dbget-bin/www_bget?rn:R02734 OMA ITANLYI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ITANLYI PROSITE PS00758 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00758 PROSITE PS00759 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00759 PSORT swissprot:DAPE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DAPE_ECOLI PSORT-B swissprot:DAPE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DAPE_ECOLI PSORT2 swissprot:DAPE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DAPE_ECOLI Pfam PF01546 http://pfam.xfam.org/family/PF01546 Pfam PF07687 http://pfam.xfam.org/family/PF07687 Phobius swissprot:DAPE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DAPE_ECOLI PhylomeDB P0AED7 http://phylomedb.org/?seqid=P0AED7 ProteinModelPortal P0AED7 http://www.proteinmodelportal.org/query/uniprot/P0AED7 PubMed 1644751 http://www.ncbi.nlm.nih.gov/pubmed/1644751 PubMed 1644752 http://www.ncbi.nlm.nih.gov/pubmed/1644752 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3276674 http://www.ncbi.nlm.nih.gov/pubmed/3276674 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416967 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416967 RefSeq WP_001277801 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001277801 SMR P0AED7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AED7 STRING 511145.b2472 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2472&targetmode=cogs STRING COG0624 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0624&targetmode=cogs SUPFAM SSF55031 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55031 TIGRFAMs TIGR01246 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01246 UniProtKB DAPE_ECOLI http://www.uniprot.org/uniprot/DAPE_ECOLI UniProtKB-AC P0AED7 http://www.uniprot.org/uniprot/P0AED7 charge swissprot:DAPE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DAPE_ECOLI eggNOG COG0624 http://eggnogapi.embl.de/nog_data/html/tree/COG0624 eggNOG ENOG4105C9Y http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C9Y epestfind swissprot:DAPE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DAPE_ECOLI garnier swissprot:DAPE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DAPE_ECOLI helixturnhelix swissprot:DAPE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DAPE_ECOLI hmoment swissprot:DAPE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DAPE_ECOLI iep swissprot:DAPE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DAPE_ECOLI inforesidue swissprot:DAPE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DAPE_ECOLI octanol swissprot:DAPE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DAPE_ECOLI pepcoil swissprot:DAPE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DAPE_ECOLI pepdigest swissprot:DAPE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DAPE_ECOLI pepinfo swissprot:DAPE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DAPE_ECOLI pepnet swissprot:DAPE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DAPE_ECOLI pepstats swissprot:DAPE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DAPE_ECOLI pepwheel swissprot:DAPE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DAPE_ECOLI pepwindow swissprot:DAPE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DAPE_ECOLI sigcleave swissprot:DAPE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DAPE_ECOLI ## Database ID URL or Descriptions # AltName RLMB_ECOLI 23S rRNA (guanosine2251 2'-O)-methyltransferase # AltName RLMB_ECOLI 23S rRNA Gm2251 2'-O-methyltransferase # BRENDA 2.1.1.185 2026 # BioGrid 4261811 9 # CATALYTIC ACTIVITY S-adenosyl-L-methionine + guanosine(2251) in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylguanosine(2251) in 23S rRNA. {ECO:0000269|PubMed 11698387}. # EcoGene EG12483 rlmB # FUNCTION RLMB_ECOLI Specifically methylates the ribose of guanosine 2251 in 23S rRNA. {ECO 0000269|PubMed 11698387}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003723 RNA binding; IBA:GO_Central. # GO_function GO:0070039 rRNA (guanosine-2'-O-)-methyltransferase activity; IMP:EcoCyc. # GO_process GO:0000453 enzyme-directed rRNA 2'-O-methylation; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.30.1330.30 -; 1. # Gene3D 3.40.1280.10 -; 1. # HAMAP MF_01887 23SrRNA_methyltr_B # IntAct P63177 19 # InterPro IPR001537 SpoU_MeTrfase # InterPro IPR004441 rRNA_MeTrfase_TrmH # InterPro IPR013123 SpoU_subst-bd # InterPro IPR024915 23S_rRNA_MeTrfase_RlmB # InterPro IPR029026 tRNA_m1G_MTases_N # InterPro IPR029028 Alpha/beta_knot_MTases # InterPro IPR029064 L30e-like # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # Organism RLMB_ECOLI Escherichia coli (strain K12) # PATRIC 32123935 VBIEscCol129921_4312 # PDB 1GZ0 X-ray; 2.50 A; A/B/C/D/E/F/G/H=1-243 # PIR S56405 S56405 # Pfam PF00588 SpoU_methylase # Pfam PF08032 SpoU_sub_bind # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RLMB_ECOLI 23S rRNA (guanosine-2'-O-)-methyltransferase RlmB # RefSeq NP_418601 NC_000913.3 # RefSeq WP_001293282 NZ_LN832404.1 # SIMILARITY Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. RlmB subfamily. {ECO 0000305}. # SMART SM00967 SpoU_sub_bind # SUBCELLULAR LOCATION RLMB_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 12377117}. # SUPFAM SSF55315 SSF55315 # SUPFAM SSF75217 SSF75217 # TIGRFAMs TIGR00186 rRNA_methyl_3 # eggNOG COG0566 LUCA # eggNOG ENOG4105C2N Bacteria BLAST swissprot:RLMB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RLMB_ECOLI BioCyc ECOL316407:JW4138-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4138-MONOMER BioCyc EcoCyc:G7845-MONOMER http://biocyc.org/getid?id=EcoCyc:G7845-MONOMER BioCyc MetaCyc:G7845-MONOMER http://biocyc.org/getid?id=MetaCyc:G7845-MONOMER COG COG0566 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0566 DIP DIP-47866N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47866N DOI 10.1016/S0969-2126(02)00852-3 http://dx.doi.org/10.1016/S0969-2126(02)00852-3 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.183.23.6957-6960.2001 http://dx.doi.org/10.1128/JB.183.23.6957-6960.2001 EC_number EC:2.1.1.185 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.185 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 2.1.1.185 http://enzyme.expasy.org/EC/2.1.1.185 EchoBASE EB2376 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2376 EcoGene EG12483 http://www.ecogene.org/geneInfo.php?eg_id=EG12483 EnsemblBacteria AAC77137 http://www.ensemblgenomes.org/id/AAC77137 EnsemblBacteria AAC77137 http://www.ensemblgenomes.org/id/AAC77137 EnsemblBacteria BAE78181 http://www.ensemblgenomes.org/id/BAE78181 EnsemblBacteria BAE78181 http://www.ensemblgenomes.org/id/BAE78181 EnsemblBacteria BAE78181 http://www.ensemblgenomes.org/id/BAE78181 EnsemblBacteria b4180 http://www.ensemblgenomes.org/id/b4180 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0070039 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070039 GO_process GO:0000453 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000453 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.30.1330.30 http://www.cathdb.info/version/latest/superfamily/3.30.1330.30 Gene3D 3.40.1280.10 http://www.cathdb.info/version/latest/superfamily/3.40.1280.10 GeneID 948694 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948694 HAMAP MF_01887 http://hamap.expasy.org/unirule/MF_01887 HOGENOM HOG000218798 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218798&db=HOGENOM6 InParanoid P63177 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P63177 IntAct P63177 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P63177* IntEnz 2.1.1.185 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.185 InterPro IPR001537 http://www.ebi.ac.uk/interpro/entry/IPR001537 InterPro IPR004441 http://www.ebi.ac.uk/interpro/entry/IPR004441 InterPro IPR013123 http://www.ebi.ac.uk/interpro/entry/IPR013123 InterPro IPR024915 http://www.ebi.ac.uk/interpro/entry/IPR024915 InterPro IPR029026 http://www.ebi.ac.uk/interpro/entry/IPR029026 InterPro IPR029028 http://www.ebi.ac.uk/interpro/entry/IPR029028 InterPro IPR029064 http://www.ebi.ac.uk/interpro/entry/IPR029064 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW4138 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4138 KEGG_Gene eco:b4180 http://www.genome.jp/dbget-bin/www_bget?eco:b4180 KEGG_Orthology KO:K03218 http://www.genome.jp/dbget-bin/www_bget?KO:K03218 OMA WVEGVHQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WVEGVHQ PDB 1GZ0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1GZ0 PDBsum 1GZ0 http://www.ebi.ac.uk/pdbsum/1GZ0 PSORT swissprot:RLMB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RLMB_ECOLI PSORT-B swissprot:RLMB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RLMB_ECOLI PSORT2 swissprot:RLMB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RLMB_ECOLI Pfam PF00588 http://pfam.xfam.org/family/PF00588 Pfam PF08032 http://pfam.xfam.org/family/PF08032 Phobius swissprot:RLMB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RLMB_ECOLI PhylomeDB P63177 http://phylomedb.org/?seqid=P63177 ProteinModelPortal P63177 http://www.proteinmodelportal.org/query/uniprot/P63177 PubMed 11698387 http://www.ncbi.nlm.nih.gov/pubmed/11698387 PubMed 12377117 http://www.ncbi.nlm.nih.gov/pubmed/12377117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418601 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418601 RefSeq WP_001293282 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001293282 SMART SM00967 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00967 SMR P63177 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P63177 STRING 511145.b4180 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4180&targetmode=cogs STRING COG0566 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0566&targetmode=cogs SUPFAM SSF55315 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55315 SUPFAM SSF75217 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF75217 TIGRFAMs TIGR00186 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00186 UniProtKB RLMB_ECOLI http://www.uniprot.org/uniprot/RLMB_ECOLI UniProtKB-AC P63177 http://www.uniprot.org/uniprot/P63177 charge swissprot:RLMB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RLMB_ECOLI eggNOG COG0566 http://eggnogapi.embl.de/nog_data/html/tree/COG0566 eggNOG ENOG4105C2N http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C2N epestfind swissprot:RLMB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RLMB_ECOLI garnier swissprot:RLMB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RLMB_ECOLI helixturnhelix swissprot:RLMB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RLMB_ECOLI hmoment swissprot:RLMB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RLMB_ECOLI iep swissprot:RLMB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RLMB_ECOLI inforesidue swissprot:RLMB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RLMB_ECOLI octanol swissprot:RLMB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RLMB_ECOLI pepcoil swissprot:RLMB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RLMB_ECOLI pepdigest swissprot:RLMB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RLMB_ECOLI pepinfo swissprot:RLMB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RLMB_ECOLI pepnet swissprot:RLMB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RLMB_ECOLI pepstats swissprot:RLMB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RLMB_ECOLI pepwheel swissprot:RLMB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RLMB_ECOLI pepwindow swissprot:RLMB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RLMB_ECOLI sigcleave swissprot:RLMB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RLMB_ECOLI ## Database ID URL or Descriptions # BioGrid 4259610 12 # EcoGene EG11931 yjbM # IntAct P32694 5 # InterPro IPR020404 DUF2713 # Organism YJBM_ECOLI Escherichia coli (strain K12) # PATRIC 32123633 VBIEscCol129921_4165 # PIR G65212 G65212 # Pfam PF10897 DUF2713 # ProDom PD116985 Uncharacterised_YjbM_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJBM_ECOLI Uncharacterized protein YjbM # RefSeq NP_418472 NC_000913.3 # RefSeq WP_001311303 NZ_LN832404.1 BLAST swissprot:YJBM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJBM_ECOLI BioCyc ECOL316407:JW4008-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4008-MONOMER BioCyc EcoCyc:EG11931-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11931-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1875 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1875 EcoGene EG11931 http://www.ecogene.org/geneInfo.php?eg_id=EG11931 EnsemblBacteria AAC77018 http://www.ensemblgenomes.org/id/AAC77018 EnsemblBacteria AAC77018 http://www.ensemblgenomes.org/id/AAC77018 EnsemblBacteria BAE78050 http://www.ensemblgenomes.org/id/BAE78050 EnsemblBacteria BAE78050 http://www.ensemblgenomes.org/id/BAE78050 EnsemblBacteria BAE78050 http://www.ensemblgenomes.org/id/BAE78050 EnsemblBacteria b4048 http://www.ensemblgenomes.org/id/b4048 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 948550 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948550 HOGENOM HOG000009673 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009673&db=HOGENOM6 IntAct P32694 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32694* InterPro IPR020404 http://www.ebi.ac.uk/interpro/entry/IPR020404 KEGG_Gene ecj:JW4008 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4008 KEGG_Gene eco:b4048 http://www.genome.jp/dbget-bin/www_bget?eco:b4048 OMA PIERYTF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PIERYTF PSORT swissprot:YJBM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJBM_ECOLI PSORT-B swissprot:YJBM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJBM_ECOLI PSORT2 swissprot:YJBM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJBM_ECOLI Pfam PF10897 http://pfam.xfam.org/family/PF10897 Phobius swissprot:YJBM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJBM_ECOLI ProteinModelPortal P32694 http://www.proteinmodelportal.org/query/uniprot/P32694 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418472 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418472 RefSeq WP_001311303 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001311303 STRING 511145.b4048 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4048&targetmode=cogs UniProtKB YJBM_ECOLI http://www.uniprot.org/uniprot/YJBM_ECOLI UniProtKB-AC P32694 http://www.uniprot.org/uniprot/P32694 charge swissprot:YJBM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJBM_ECOLI epestfind swissprot:YJBM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJBM_ECOLI garnier swissprot:YJBM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJBM_ECOLI helixturnhelix swissprot:YJBM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJBM_ECOLI hmoment swissprot:YJBM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJBM_ECOLI iep swissprot:YJBM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJBM_ECOLI inforesidue swissprot:YJBM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJBM_ECOLI octanol swissprot:YJBM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJBM_ECOLI pepcoil swissprot:YJBM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJBM_ECOLI pepdigest swissprot:YJBM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJBM_ECOLI pepinfo swissprot:YJBM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJBM_ECOLI pepnet swissprot:YJBM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJBM_ECOLI pepstats swissprot:YJBM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJBM_ECOLI pepwheel swissprot:YJBM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJBM_ECOLI pepwindow swissprot:YJBM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJBM_ECOLI sigcleave swissprot:YJBM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJBM_ECOLI ## Database ID URL or Descriptions # BioGrid 4263352 8 # CDD cd06261 TM_PBP2 # EcoGene EG11627 artM # FUNCTION ARTM_ECOLI Part of the ABC transporter complex ArtPIQMJ involved in arginine transport. Probably responsible for the translocation of the substrate across the membrane. {ECO 0000269|PubMed 8801422}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; ISM:EcoCyc. # GO_function GO:0015171 amino acid transmembrane transporter activity; IBA:GO_Central. # GO_process GO:1902765 L-arginine import into cell; ISO:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # Gene3D 1.10.3720.10 -; 1. # IntAct P0AE30 2 # InterPro IPR000515 MetI-like # InterPro IPR010065 AA_ABC_transptr_permease_3TM # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00229 Arginine transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism ARTM_ECOLI Escherichia coli (strain K12) # PATRIC 32116929 VBIEscCol129921_0890 # PIR E64824 E64824 # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ARTM_ECOLI Arginine ABC transporter permease protein ArtM # RefSeq NP_415382 NC_000913.3 # RefSeq WP_000464491 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION ARTM_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT The complex is composed of two ATP-binding proteins (ArtP), two transmembrane proteins (ArtM and ArtQ) and two solute- binding proteins (ArtJ and ArtI). {ECO:0000305|PubMed 8801422}. # SUPFAM SSF161098 SSF161098 # TCDB 3.A.1.3 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR01726 HEQRo_perm_3TM # eggNOG COG4160 LUCA # eggNOG ENOG4105DMR Bacteria BLAST swissprot:ARTM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARTM_ECOLI BioCyc ECOL316407:JW0845-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0845-MONOMER BioCyc EcoCyc:ARTM-MONOMER http://biocyc.org/getid?id=EcoCyc:ARTM-MONOMER BioCyc MetaCyc:ARTM-MONOMER http://biocyc.org/getid?id=MetaCyc:ARTM-MONOMER COG COG4160 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4160 DIP DIP-48169N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48169N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1995.mmi_17040675.x http://dx.doi.org/10.1111/j.1365-2958.1995.mmi_17040675.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X86160 http://www.ebi.ac.uk/ena/data/view/X86160 EchoBASE EB1584 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1584 EcoGene EG11627 http://www.ecogene.org/geneInfo.php?eg_id=EG11627 EnsemblBacteria AAC73948 http://www.ensemblgenomes.org/id/AAC73948 EnsemblBacteria AAC73948 http://www.ensemblgenomes.org/id/AAC73948 EnsemblBacteria BAA35575 http://www.ensemblgenomes.org/id/BAA35575 EnsemblBacteria BAA35575 http://www.ensemblgenomes.org/id/BAA35575 EnsemblBacteria BAA35575 http://www.ensemblgenomes.org/id/BAA35575 EnsemblBacteria b0861 http://www.ensemblgenomes.org/id/b0861 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015171 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015171 GO_process GO:1902765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902765 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 949066 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949066 HOGENOM HOG000267552 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267552&db=HOGENOM6 InParanoid P0AE30 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AE30 IntAct P0AE30 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AE30* InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 InterPro IPR010065 http://www.ebi.ac.uk/interpro/entry/IPR010065 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0845 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0845 KEGG_Gene eco:b0861 http://www.genome.jp/dbget-bin/www_bget?eco:b0861 KEGG_Orthology KO:K09998 http://www.genome.jp/dbget-bin/www_bget?KO:K09998 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA RSADQMF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RSADQMF PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:ARTM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARTM_ECOLI PSORT-B swissprot:ARTM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARTM_ECOLI PSORT2 swissprot:ARTM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARTM_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Phobius swissprot:ARTM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARTM_ECOLI PhylomeDB P0AE30 http://phylomedb.org/?seqid=P0AE30 ProteinModelPortal P0AE30 http://www.proteinmodelportal.org/query/uniprot/P0AE30 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8501075 http://www.ncbi.nlm.nih.gov/pubmed/8501075 PubMed 8801422 http://www.ncbi.nlm.nih.gov/pubmed/8801422 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415382 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415382 RefSeq WP_000464491 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000464491 STRING 511145.b0861 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0861&targetmode=cogs STRING COG4160 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4160&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.3 http://www.tcdb.org/search/result.php?tc=3.A.1.3 TIGRFAMs TIGR01726 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01726 UniProtKB ARTM_ECOLI http://www.uniprot.org/uniprot/ARTM_ECOLI UniProtKB-AC P0AE30 http://www.uniprot.org/uniprot/P0AE30 charge swissprot:ARTM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARTM_ECOLI eggNOG COG4160 http://eggnogapi.embl.de/nog_data/html/tree/COG4160 eggNOG ENOG4105DMR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DMR epestfind swissprot:ARTM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARTM_ECOLI garnier swissprot:ARTM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARTM_ECOLI helixturnhelix swissprot:ARTM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARTM_ECOLI hmoment swissprot:ARTM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARTM_ECOLI iep swissprot:ARTM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARTM_ECOLI inforesidue swissprot:ARTM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARTM_ECOLI octanol swissprot:ARTM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARTM_ECOLI pepcoil swissprot:ARTM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARTM_ECOLI pepdigest swissprot:ARTM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARTM_ECOLI pepinfo swissprot:ARTM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARTM_ECOLI pepnet swissprot:ARTM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARTM_ECOLI pepstats swissprot:ARTM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARTM_ECOLI pepwheel swissprot:ARTM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARTM_ECOLI pepwindow swissprot:ARTM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARTM_ECOLI sigcleave swissprot:ARTM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARTM_ECOLI ## Database ID URL or Descriptions # BioGrid 4260214 14 # EcoGene EG11645 ydeJ # FUNCTION YDEJ_ECOLI Does not have nicotinamide-nucleotide (NMN) amidohydrolase activity. # Gene3D 3.90.950.20 -; 1. # IntAct P31131 6 # InterPro IPR008136 CinA_C # Organism YDEJ_ECOLI Escherichia coli (strain K12) # PATRIC 32118374 VBIEscCol129921_1607 # PIR D64908 D64908 # Pfam PF02464 CinA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDEJ_ECOLI Protein YdeJ # RefSeq NP_416055 NC_000913.3 # RefSeq WP_001024746 NZ_LN832404.1 # SIMILARITY Belongs to the CinA family. {ECO 0000305}. # SUPFAM SSF142433 SSF142433 # TIGRFAMs TIGR00199 PncC_domain # eggNOG COG1546 LUCA # eggNOG ENOG4108WTK Bacteria BLAST swissprot:YDEJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDEJ_ECOLI BioCyc ECOL316407:JW1530-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1530-MONOMER BioCyc EcoCyc:EG11645-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11645-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M111.275818 http://dx.doi.org/10.1074/jbc.M111.275818 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M96235 http://www.ebi.ac.uk/ena/data/view/M96235 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1598 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1598 EcoGene EG11645 http://www.ecogene.org/geneInfo.php?eg_id=EG11645 EnsemblBacteria AAC74610 http://www.ensemblgenomes.org/id/AAC74610 EnsemblBacteria AAC74610 http://www.ensemblgenomes.org/id/AAC74610 EnsemblBacteria BAA15227 http://www.ensemblgenomes.org/id/BAA15227 EnsemblBacteria BAA15227 http://www.ensemblgenomes.org/id/BAA15227 EnsemblBacteria BAA15227 http://www.ensemblgenomes.org/id/BAA15227 EnsemblBacteria b1537 http://www.ensemblgenomes.org/id/b1537 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.90.950.20 http://www.cathdb.info/version/latest/superfamily/3.90.950.20 GeneID 946067 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946067 HOGENOM HOG000242527 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000242527&db=HOGENOM6 InParanoid P31131 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31131 IntAct P31131 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31131* InterPro IPR008136 http://www.ebi.ac.uk/interpro/entry/IPR008136 KEGG_Gene ecj:JW1530 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1530 KEGG_Gene eco:b1537 http://www.genome.jp/dbget-bin/www_bget?eco:b1537 OMA CAEENTA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CAEENTA PSORT swissprot:YDEJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDEJ_ECOLI PSORT-B swissprot:YDEJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDEJ_ECOLI PSORT2 swissprot:YDEJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDEJ_ECOLI Pfam PF02464 http://pfam.xfam.org/family/PF02464 Phobius swissprot:YDEJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDEJ_ECOLI PhylomeDB P31131 http://phylomedb.org/?seqid=P31131 ProteinModelPortal P31131 http://www.proteinmodelportal.org/query/uniprot/P31131 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21953451 http://www.ncbi.nlm.nih.gov/pubmed/21953451 PubMed 8383113 http://www.ncbi.nlm.nih.gov/pubmed/8383113 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416055 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416055 RefSeq WP_001024746 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001024746 SMR P31131 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31131 STRING 511145.b1537 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1537&targetmode=cogs SUPFAM SSF142433 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF142433 TIGRFAMs TIGR00199 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00199 UniProtKB YDEJ_ECOLI http://www.uniprot.org/uniprot/YDEJ_ECOLI UniProtKB-AC P31131 http://www.uniprot.org/uniprot/P31131 charge swissprot:YDEJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDEJ_ECOLI eggNOG COG1546 http://eggnogapi.embl.de/nog_data/html/tree/COG1546 eggNOG ENOG4108WTK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108WTK epestfind swissprot:YDEJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDEJ_ECOLI garnier swissprot:YDEJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDEJ_ECOLI helixturnhelix swissprot:YDEJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDEJ_ECOLI hmoment swissprot:YDEJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDEJ_ECOLI iep swissprot:YDEJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDEJ_ECOLI inforesidue swissprot:YDEJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDEJ_ECOLI octanol swissprot:YDEJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDEJ_ECOLI pepcoil swissprot:YDEJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDEJ_ECOLI pepdigest swissprot:YDEJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDEJ_ECOLI pepinfo swissprot:YDEJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDEJ_ECOLI pepnet swissprot:YDEJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDEJ_ECOLI pepstats swissprot:YDEJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDEJ_ECOLI pepwheel swissprot:YDEJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDEJ_ECOLI pepwindow swissprot:YDEJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDEJ_ECOLI sigcleave swissprot:YDEJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDEJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4260202 148 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG10010 rhsE # FUNCTION RHSE_ECOLI Rhs elements have a nonessential function. They may play an important role in the natural ecology of the cell. # GO_process GO:0097264 self proteolysis; IEA:InterPro. # GOslim_process GO:0008150 biological_process # IntAct P24211 24 # InterPro IPR001826 RHS # InterPro IPR022385 Rhs_assc_core # Organism RHSE_ECOLI Escherichia coli (strain K12) # PATRIC 48662222 VBIEscCol107702_1473 # PIR C64898 C64898 # PRINTS PR00394 RHSPROTEIN # Pfam PF03527 RHS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RHSE_ECOLI Putative protein RhsE # SIMILARITY Belongs to the RHS family. {ECO 0000305}. # TIGRFAMs TIGR03696 Rhs_assc_core # eggNOG COG3209 LUCA # eggNOG ENOG4107TV1 Bacteria BLAST swissprot:RHSE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RHSE_ECOLI BioCyc ECOL316407:JW1451-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1451-MONOMER BioCyc EcoCyc:EG10010-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10010-MONOMER DIP DIP-10703N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10703N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/19.25.7177 http://dx.doi.org/10.1093/nar/19.25.7177 DOI 10.1111/j.1365-2958.1994.tb01074.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb01074.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X60998 http://www.ebi.ac.uk/ena/data/view/X60998 EchoBASE EB0010 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0010 EcoGene EG10010 http://www.ecogene.org/geneInfo.php?eg_id=EG10010 EnsemblBacteria BAA15087 http://www.ensemblgenomes.org/id/BAA15087 EnsemblBacteria BAA15087 http://www.ensemblgenomes.org/id/BAA15087 EnsemblBacteria BAA15087 http://www.ensemblgenomes.org/id/BAA15087 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0097264 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097264 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 HOGENOM HOG000225201 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000225201&db=HOGENOM6 InParanoid P24211 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P24211 IntAct P24211 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P24211* InterPro IPR001826 http://www.ebi.ac.uk/interpro/entry/IPR001826 InterPro IPR022385 http://www.ebi.ac.uk/interpro/entry/IPR022385 KEGG_Gene ecj:JW1451 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1451 MINT MINT-1319693 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1319693 OMA RIRYESH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RIRYESH PRINTS PR00394 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00394 PSORT swissprot:RHSE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RHSE_ECOLI PSORT-B swissprot:RHSE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RHSE_ECOLI PSORT2 swissprot:RHSE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RHSE_ECOLI Pfam PF03527 http://pfam.xfam.org/family/PF03527 Phobius swissprot:RHSE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RHSE_ECOLI PhylomeDB P24211 http://phylomedb.org/?seqid=P24211 ProteinModelPortal P24211 http://www.proteinmodelportal.org/query/uniprot/P24211 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1766878 http://www.ncbi.nlm.nih.gov/pubmed/1766878 PubMed 7934896 http://www.ncbi.nlm.nih.gov/pubmed/7934896 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 STRING 316407.1742368 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.1742368&targetmode=cogs TIGRFAMs TIGR03696 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03696 UniProtKB RHSE_ECOLI http://www.uniprot.org/uniprot/RHSE_ECOLI UniProtKB-AC P24211 http://www.uniprot.org/uniprot/P24211 charge swissprot:RHSE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RHSE_ECOLI eggNOG COG3209 http://eggnogapi.embl.de/nog_data/html/tree/COG3209 eggNOG ENOG4107TV1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107TV1 epestfind swissprot:RHSE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RHSE_ECOLI garnier swissprot:RHSE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RHSE_ECOLI helixturnhelix swissprot:RHSE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RHSE_ECOLI hmoment swissprot:RHSE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RHSE_ECOLI iep swissprot:RHSE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RHSE_ECOLI inforesidue swissprot:RHSE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RHSE_ECOLI octanol swissprot:RHSE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RHSE_ECOLI pepcoil swissprot:RHSE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RHSE_ECOLI pepdigest swissprot:RHSE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RHSE_ECOLI pepinfo swissprot:RHSE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RHSE_ECOLI pepnet swissprot:RHSE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RHSE_ECOLI pepstats swissprot:RHSE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RHSE_ECOLI pepwheel swissprot:RHSE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RHSE_ECOLI pepwindow swissprot:RHSE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RHSE_ECOLI sigcleave swissprot:RHSE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RHSE_ECOLI ## Database ID URL or Descriptions # AltName CDH_ECOLI CDP-diacylglycerol phosphatidylhydrolase # AltName CDH_ECOLI CDP-diglyceride hydrolase # BioGrid 4261218 158 # CATALYTIC ACTIVITY CDH_ECOLI CDP-diacylglycerol + H(2)O = CMP + phosphatidate. # EcoGene EG10138 cdh # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0008715 CDP-diacylglycerol diphosphatase activity; IDA:EcoCyc. # GO_process GO:0008654 phospholipid biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0046342 CDP-diacylglycerol catabolic process; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # HAMAP MF_00319 Cdh # IntAct P06282 3 # InterPro IPR003763 CDP-diacylglyc_Pase # InterPro IPR011146 HIT-like # InterPro IPR015993 CDP-diacylglyc_Pase_proteobac # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00564 Glycerophospholipid metabolism # Organism CDH_ECOLI Escherichia coli (strain K12) # PATHWAY Phospholipid metabolism; CDP-diacylglycerol degradation; phosphatidate from CDP-diacylglycerol step 1/1. # PATRIC 32123349 VBIEscCol129921_4035 # PIR A01019 PSECCD # PIRSF PIRSF001273 CDH # Pfam PF02611 CDH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CDH_ECOLI CDP-diacylglycerol pyrophosphatase # RefSeq NP_418353 NC_000913.3 # RefSeq WP_001326656 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA26358.1; Type=Frameshift; Positions=Several; Evidence={ECO 0000305}; # SIMILARITY Belongs to the Cdh family. {ECO 0000305}. # SUBCELLULAR LOCATION CDH_ECOLI Cell inner membrane; Single-pass membrane protein. # SUPFAM SSF54197 SSF54197 # TIGRFAMs TIGR00672 cdh # UniPathway UPA00609 UER00664 # eggNOG COG2134 LUCA # eggNOG ENOG4105EAF Bacteria BLAST swissprot:CDH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CDH_ECOLI BioCyc ECOL316407:JW3889-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3889-MONOMER BioCyc EcoCyc:CDPDIGLYPYPHOSPHA-MONOMER http://biocyc.org/getid?id=EcoCyc:CDPDIGLYPYPHOSPHA-MONOMER BioCyc MetaCyc:CDPDIGLYPYPHOSPHA-MONOMER http://biocyc.org/getid?id=MetaCyc:CDPDIGLYPYPHOSPHA-MONOMER COG COG2134 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2134 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1111/j.1432-1033.1985.tb08934.x http://dx.doi.org/10.1111/j.1432-1033.1985.tb08934.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.1.26 http://www.genome.jp/dbget-bin/www_bget?EC:3.6.1.26 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL M11331 http://www.ebi.ac.uk/ena/data/view/M11331 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X02519 http://www.ebi.ac.uk/ena/data/view/X02519 ENZYME 3.6.1.26 http://enzyme.expasy.org/EC/3.6.1.26 EchoBASE EB0136 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0136 EcoGene EG10138 http://www.ecogene.org/geneInfo.php?eg_id=EG10138 EnsemblBacteria AAC76900 http://www.ensemblgenomes.org/id/AAC76900 EnsemblBacteria AAC76900 http://www.ensemblgenomes.org/id/AAC76900 EnsemblBacteria BAE77392 http://www.ensemblgenomes.org/id/BAE77392 EnsemblBacteria BAE77392 http://www.ensemblgenomes.org/id/BAE77392 EnsemblBacteria BAE77392 http://www.ensemblgenomes.org/id/BAE77392 EnsemblBacteria b3918 http://www.ensemblgenomes.org/id/b3918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008715 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008715 GO_process GO:0008654 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008654 GO_process GO:0046342 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046342 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 948410 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948410 HAMAP MF_00319 http://hamap.expasy.org/unirule/MF_00319 HOGENOM HOG000048713 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000048713&db=HOGENOM6 InParanoid P06282 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P06282 IntAct P06282 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P06282* IntEnz 3.6.1.26 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.1.26 InterPro IPR003763 http://www.ebi.ac.uk/interpro/entry/IPR003763 InterPro IPR011146 http://www.ebi.ac.uk/interpro/entry/IPR011146 InterPro IPR015993 http://www.ebi.ac.uk/interpro/entry/IPR015993 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3889 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3889 KEGG_Gene eco:b3918 http://www.genome.jp/dbget-bin/www_bget?eco:b3918 KEGG_Orthology KO:K01521 http://www.genome.jp/dbget-bin/www_bget?KO:K01521 KEGG_Pathway ko00564 http://www.genome.jp/kegg-bin/show_pathway?ko00564 KEGG_Reaction rn:R01797 http://www.genome.jp/dbget-bin/www_bget?rn:R01797 OMA SPFIMLA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SPFIMLA PSORT swissprot:CDH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CDH_ECOLI PSORT-B swissprot:CDH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CDH_ECOLI PSORT2 swissprot:CDH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CDH_ECOLI Pfam PF02611 http://pfam.xfam.org/family/PF02611 Phobius swissprot:CDH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CDH_ECOLI PhylomeDB P06282 http://phylomedb.org/?seqid=P06282 ProteinModelPortal P06282 http://www.proteinmodelportal.org/query/uniprot/P06282 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2995360 http://www.ncbi.nlm.nih.gov/pubmed/2995360 PubMed 3158524 http://www.ncbi.nlm.nih.gov/pubmed/3158524 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418353 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418353 RefSeq WP_001326656 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001326656 SMR P06282 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P06282 STRING 511145.b3918 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3918&targetmode=cogs STRING COG2134 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2134&targetmode=cogs SUPFAM SSF54197 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54197 TIGRFAMs TIGR00672 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00672 UniProtKB CDH_ECOLI http://www.uniprot.org/uniprot/CDH_ECOLI UniProtKB-AC P06282 http://www.uniprot.org/uniprot/P06282 charge swissprot:CDH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CDH_ECOLI eggNOG COG2134 http://eggnogapi.embl.de/nog_data/html/tree/COG2134 eggNOG ENOG4105EAF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EAF epestfind swissprot:CDH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CDH_ECOLI garnier swissprot:CDH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CDH_ECOLI helixturnhelix swissprot:CDH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CDH_ECOLI hmoment swissprot:CDH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CDH_ECOLI iep swissprot:CDH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CDH_ECOLI inforesidue swissprot:CDH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CDH_ECOLI octanol swissprot:CDH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CDH_ECOLI pepcoil swissprot:CDH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CDH_ECOLI pepdigest swissprot:CDH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CDH_ECOLI pepinfo swissprot:CDH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CDH_ECOLI pepnet swissprot:CDH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CDH_ECOLI pepstats swissprot:CDH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CDH_ECOLI pepwheel swissprot:CDH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CDH_ECOLI pepwindow swissprot:CDH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CDH_ECOLI sigcleave swissprot:CDH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CDH_ECOLI ## Database ID URL or Descriptions # BioGrid 4263404 321 # EcoGene EG10766 secY # FUNCTION SECY_ECOLI The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. SecY is required to insert newly synthesized SecY into the inner membrane. Overexpression of some hybrid proteins has been thought to jam the protein secretion apparatus resulting in cell death; while this may be true, overexpression also results in FtsH-mediated degradation of SecY. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:CACAO. # GO_component GO:0016021 integral component of membrane; IDA:EcoliWiki. # GO_process GO:0006605 protein targeting; IEA:UniProtKB-HAMAP. # GO_process GO:0006886 intracellular protein transport; IMP:EcoliWiki. # GO_process GO:0043952 protein transport by the Sec complex; IDA:EcoCyc. # GO_process GO:0065002 intracellular protein transmembrane transport; IMP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005622 intracellular # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006605 protein targeting # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # Gene3D 1.10.3370.10 -; 1. # HAMAP MF_01465 SecY # INTERACTION SECY_ECOLI P10408 secA; NbExp=4; IntAct=EBI-761422, EBI-543213; # IntAct P0AGA2 2 # InterPro IPR002208 SecY/SEC61-alpha # InterPro IPR023201 SecY_su_dom # InterPro IPR026593 SecY # InterPro IPR030659 SecY_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02044 M00335 Sec (secretion) system # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko03060 Protein export # KEGG_Pathway ko03070 Bacterial secretion system # Organism SECY_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10906 PTHR10906 # PATRIC 32122032 VBIEscCol129921_3393 # PDB 2AKH EM; 14.90 A; B/Y=1-436 # PDB 2AKI EM; 14.90 A; B/Y=1-436 # PDB 3J45 EM; 9.50 A; y=6-440 # PDB 3J46 EM; 10.10 A; y=6-440 # PDB 4V6M EM; -; A=8-442 # PDB 5ABB EM; 8.00 A; A=1-443 # PDB 5GAE EM; 3.33 A; g=1-443 # PIR A04473 QQECSY # PIRSF PIRSF004557 SecY # PROSITE PS00755 SECY_1 # PROSITE PS00756 SECY_2 # PTM SECY_ECOLI SecY that is not part of the protein translocation apparatus is degraded by FtsH. Also degraded by FtsH when the SecYEG complex is jammed, or upon treatment with antibiotics that block translation elongation such as chloramphenicol. # Pfam PF00344 SecY # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SECY_ECOLI Protein translocase subunit SecY # RefSeq NP_417759 NC_000913.3 # RefSeq WP_001118861 NZ_LN832404.1 # SIMILARITY Belongs to the SecY/SEC61-alpha family. {ECO 0000305}. # SUBCELLULAR LOCATION SECY_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT SECY_ECOLI Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF-YajC and YidC; YidC interacts with nascent inner membrane proteins after SecY. SecY probably contacts the 23S rRNA and possibly also ribosomal protein L23 during ribosome docking. A single SecY molecule forms the translocating pore, although interaction with SecA may require oligomers. {ECO 0000269|PubMed 11415986, ECO 0000269|PubMed 17418789}. # SUPFAM SSF103491 SSF103491 # TCDB 3.A.5.1 the general secretory pathway (sec) family # TIGRFAMs TIGR00967 3a0501s007 # eggNOG COG0201 LUCA # eggNOG ENOG4105CGG Bacteria BLAST swissprot:SECY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SECY_ECOLI BioCyc ECOL316407:JW3262-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3262-MONOMER BioCyc EcoCyc:SECY http://biocyc.org/getid?id=EcoCyc:SECY COG COG0201 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0201 DIP DIP-59302N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-59302N DOI 10.1007/BF00763172 http://dx.doi.org/10.1007/BF00763172 DOI 10.1016/j.cell.2007.02.036 http://dx.doi.org/10.1016/j.cell.2007.02.036 DOI 10.1016/j.molcel.2007.03.022 http://dx.doi.org/10.1016/j.molcel.2007.03.022 DOI 10.1016/j.molcel.2007.05.002 http://dx.doi.org/10.1016/j.molcel.2007.05.002 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature04133 http://dx.doi.org/10.1038/nature04133 DOI 10.1038/nsmb.2026 http://dx.doi.org/10.1038/nsmb.2026 DOI 10.1073/pnas.1012556107 http://dx.doi.org/10.1073/pnas.1012556107 DOI 10.1073/pnas.91.10.4539 http://dx.doi.org/10.1073/pnas.91.10.4539 DOI 10.1073/pnas.92.10.4532 http://dx.doi.org/10.1073/pnas.92.10.4532 DOI 10.1093/embo-reports/kve108 http://dx.doi.org/10.1093/embo-reports/kve108 DOI 10.1093/nar/11.9.2599 http://dx.doi.org/10.1093/nar/11.9.2599 DOI 10.1111/j.1432-1033.1992.tb17111.x http://dx.doi.org/10.1111/j.1432-1033.1992.tb17111.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.1172221 http://dx.doi.org/10.1126/science.1172221 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1146/annurev.biochem.77.061606.160747 http://dx.doi.org/10.1146/annurev.biochem.77.061606.160747 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X01563 http://www.ebi.ac.uk/ena/data/view/X01563 EchoBASE EB0759 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0759 EcoGene EG10766 http://www.ecogene.org/geneInfo.php?eg_id=EG10766 EnsemblBacteria AAC76325 http://www.ensemblgenomes.org/id/AAC76325 EnsemblBacteria AAC76325 http://www.ensemblgenomes.org/id/AAC76325 EnsemblBacteria BAE77991 http://www.ensemblgenomes.org/id/BAE77991 EnsemblBacteria BAE77991 http://www.ensemblgenomes.org/id/BAE77991 EnsemblBacteria BAE77991 http://www.ensemblgenomes.org/id/BAE77991 EnsemblBacteria b3300 http://www.ensemblgenomes.org/id/b3300 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006605 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006605 GO_process GO:0006886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006886 GO_process GO:0043952 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043952 GO_process GO:0065002 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0065002 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006605 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006605 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 1.10.3370.10 http://www.cathdb.info/version/latest/superfamily/1.10.3370.10 GeneID 947799 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947799 HAMAP MF_01465 http://hamap.expasy.org/unirule/MF_01465 HOGENOM HOG000080585 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000080585&db=HOGENOM6 InParanoid P0AGA2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGA2 IntAct P0AGA2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AGA2* InterPro IPR002208 http://www.ebi.ac.uk/interpro/entry/IPR002208 InterPro IPR023201 http://www.ebi.ac.uk/interpro/entry/IPR023201 InterPro IPR026593 http://www.ebi.ac.uk/interpro/entry/IPR026593 InterPro IPR030659 http://www.ebi.ac.uk/interpro/entry/IPR030659 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW3262 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3262 KEGG_Gene eco:b3300 http://www.genome.jp/dbget-bin/www_bget?eco:b3300 KEGG_Orthology KO:K03076 http://www.genome.jp/dbget-bin/www_bget?KO:K03076 KEGG_Pathway ko03060 http://www.genome.jp/kegg-bin/show_pathway?ko03060 KEGG_Pathway ko03070 http://www.genome.jp/kegg-bin/show_pathway?ko03070 OMA QTYVISQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QTYVISQ PANTHER PTHR10906 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10906 PDB 2AKH http://www.ebi.ac.uk/pdbe-srv/view/entry/2AKH PDB 2AKI http://www.ebi.ac.uk/pdbe-srv/view/entry/2AKI PDB 3J45 http://www.ebi.ac.uk/pdbe-srv/view/entry/3J45 PDB 3J46 http://www.ebi.ac.uk/pdbe-srv/view/entry/3J46 PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 5ABB http://www.ebi.ac.uk/pdbe-srv/view/entry/5ABB PDB 5GAE http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAE PDBsum 2AKH http://www.ebi.ac.uk/pdbsum/2AKH PDBsum 2AKI http://www.ebi.ac.uk/pdbsum/2AKI PDBsum 3J45 http://www.ebi.ac.uk/pdbsum/3J45 PDBsum 3J46 http://www.ebi.ac.uk/pdbsum/3J46 PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 5ABB http://www.ebi.ac.uk/pdbsum/5ABB PDBsum 5GAE http://www.ebi.ac.uk/pdbsum/5GAE PROSITE PS00755 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00755 PROSITE PS00756 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00756 PSORT swissprot:SECY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SECY_ECOLI PSORT-B swissprot:SECY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SECY_ECOLI PSORT2 swissprot:SECY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SECY_ECOLI Pfam PF00344 http://pfam.xfam.org/family/PF00344 Phobius swissprot:SECY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SECY_ECOLI PhylomeDB P0AGA2 http://phylomedb.org/?seqid=P0AGA2 ProteinModelPortal P0AGA2 http://www.proteinmodelportal.org/query/uniprot/P0AGA2 PubMed 11415986 http://www.ncbi.nlm.nih.gov/pubmed/11415986 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16292303 http://www.ncbi.nlm.nih.gov/pubmed/16292303 PubMed 1633829 http://www.ncbi.nlm.nih.gov/pubmed/1633829 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17418789 http://www.ncbi.nlm.nih.gov/pubmed/17418789 PubMed 17531809 http://www.ncbi.nlm.nih.gov/pubmed/17531809 PubMed 17531810 http://www.ncbi.nlm.nih.gov/pubmed/17531810 PubMed 18078384 http://www.ncbi.nlm.nih.gov/pubmed/18078384 PubMed 19661432 http://www.ncbi.nlm.nih.gov/pubmed/19661432 PubMed 2007553 http://www.ncbi.nlm.nih.gov/pubmed/2007553 PubMed 20855604 http://www.ncbi.nlm.nih.gov/pubmed/20855604 PubMed 21499241 http://www.ncbi.nlm.nih.gov/pubmed/21499241 PubMed 2202723 http://www.ncbi.nlm.nih.gov/pubmed/2202723 PubMed 2254269 http://www.ncbi.nlm.nih.gov/pubmed/2254269 PubMed 2535843 http://www.ncbi.nlm.nih.gov/pubmed/2535843 PubMed 2646297 http://www.ncbi.nlm.nih.gov/pubmed/2646297 PubMed 2828030 http://www.ncbi.nlm.nih.gov/pubmed/2828030 PubMed 6222285 http://www.ncbi.nlm.nih.gov/pubmed/6222285 PubMed 7753838 http://www.ncbi.nlm.nih.gov/pubmed/7753838 PubMed 7889938 http://www.ncbi.nlm.nih.gov/pubmed/7889938 PubMed 8183945 http://www.ncbi.nlm.nih.gov/pubmed/8183945 PubMed 8253067 http://www.ncbi.nlm.nih.gov/pubmed/8253067 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417759 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417759 RefSeq WP_001118861 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001118861 SMR P0AGA2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AGA2 STRING 511145.b3300 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3300&targetmode=cogs STRING COG0201 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0201&targetmode=cogs SUPFAM SSF103491 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103491 TCDB 3.A.5.1 http://www.tcdb.org/search/result.php?tc=3.A.5.1 TIGRFAMs TIGR00967 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00967 UniProtKB SECY_ECOLI http://www.uniprot.org/uniprot/SECY_ECOLI UniProtKB-AC P0AGA2 http://www.uniprot.org/uniprot/P0AGA2 charge swissprot:SECY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SECY_ECOLI eggNOG COG0201 http://eggnogapi.embl.de/nog_data/html/tree/COG0201 eggNOG ENOG4105CGG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CGG epestfind swissprot:SECY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SECY_ECOLI garnier swissprot:SECY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SECY_ECOLI helixturnhelix swissprot:SECY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SECY_ECOLI hmoment swissprot:SECY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SECY_ECOLI iep swissprot:SECY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SECY_ECOLI inforesidue swissprot:SECY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SECY_ECOLI octanol swissprot:SECY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SECY_ECOLI pepcoil swissprot:SECY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SECY_ECOLI pepdigest swissprot:SECY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SECY_ECOLI pepinfo swissprot:SECY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SECY_ECOLI pepnet swissprot:SECY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SECY_ECOLI pepstats swissprot:SECY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SECY_ECOLI pepwheel swissprot:SECY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SECY_ECOLI pepwindow swissprot:SECY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SECY_ECOLI sigcleave swissprot:SECY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SECY_ECOLI ## Database ID URL or Descriptions # AltName YNFH_ECOLI DMSO reductase anchor subunit YnfH # BioGrid 4263479 7 # EcoGene EG13846 ynfH # FUNCTION YNFH_ECOLI Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. The C subunit anchors the other two subunits to the membrane and stabilize the catalytic subunits (By similarity). {ECO 0000250}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0016491 oxidoreductase activity; IEA:UniProtKB-KW. # GO_process GO:0019645 anaerobic electron transport chain; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006091 generation of precursor metabolites and energy # InterPro IPR007059 DmsC # KEGG_Brite ko02000 Transporters # Organism YNFH_ECOLI Escherichia coli (strain K12) # PATRIC 32118482 VBIEscCol129921_1661 # PIR H64914 H64914 # Pfam PF04976 DmsC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNFH_ECOLI Anaerobic dimethyl sulfoxide reductase chain YnfH # RefSeq NP_416107 NC_000913.3 # RefSeq WP_000526503 NZ_LN832404.1 # SIMILARITY To E.coli DmsC. {ECO 0000305}. # SUBCELLULAR LOCATION YNFH_ECOLI Cell inner membrane {ECO 0000250}; Multi- pass membrane protein {ECO 0000250}. # SUBUNIT The complex consists of three subunits: YnfF, the reductase; YnfG, an electron transfer protein, and YnfH, a membrane anchor protein. {ECO 0000305}. # TCDB 5.A.3.3 the prokaryotic molybdopterin-containing oxidoreductase (pmo) family # eggNOG COG3302 LUCA # eggNOG ENOG4107KGK Bacteria BLAST swissprot:YNFH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNFH_ECOLI BioCyc ECOL316407:JW5261-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5261-MONOMER BioCyc EcoCyc:G6848-MONOMER http://biocyc.org/getid?id=EcoCyc:G6848-MONOMER BioCyc MetaCyc:G6848-MONOMER http://biocyc.org/getid?id=MetaCyc:G6848-MONOMER COG COG3302 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3302 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3607 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3607 EcoGene EG13846 http://www.ecogene.org/geneInfo.php?eg_id=EG13846 EnsemblBacteria AAC74662 http://www.ensemblgenomes.org/id/AAC74662 EnsemblBacteria AAC74662 http://www.ensemblgenomes.org/id/AAC74662 EnsemblBacteria BAA15314 http://www.ensemblgenomes.org/id/BAA15314 EnsemblBacteria BAA15314 http://www.ensemblgenomes.org/id/BAA15314 EnsemblBacteria BAA15314 http://www.ensemblgenomes.org/id/BAA15314 EnsemblBacteria b1590 http://www.ensemblgenomes.org/id/b1590 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_process GO:0019645 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019645 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GeneID 945822 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945822 HOGENOM HOG000118381 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118381&db=HOGENOM6 InterPro IPR007059 http://www.ebi.ac.uk/interpro/entry/IPR007059 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5261 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5261 KEGG_Gene eco:b1590 http://www.genome.jp/dbget-bin/www_bget?eco:b1590 KEGG_Orthology KO:K07312 http://www.genome.jp/dbget-bin/www_bget?KO:K07312 OMA MTRVYQI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MTRVYQI PSORT swissprot:YNFH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNFH_ECOLI PSORT-B swissprot:YNFH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNFH_ECOLI PSORT2 swissprot:YNFH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNFH_ECOLI Pfam PF04976 http://pfam.xfam.org/family/PF04976 Phobius swissprot:YNFH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNFH_ECOLI ProteinModelPortal P76173 http://www.proteinmodelportal.org/query/uniprot/P76173 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416107 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416107 RefSeq WP_000526503 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000526503 STRING 511145.b1590 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1590&targetmode=cogs STRING COG3302 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3302&targetmode=cogs TCDB 5.A.3.3 http://www.tcdb.org/search/result.php?tc=5.A.3.3 UniProtKB YNFH_ECOLI http://www.uniprot.org/uniprot/YNFH_ECOLI UniProtKB-AC P76173 http://www.uniprot.org/uniprot/P76173 charge swissprot:YNFH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNFH_ECOLI eggNOG COG3302 http://eggnogapi.embl.de/nog_data/html/tree/COG3302 eggNOG ENOG4107KGK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107KGK epestfind swissprot:YNFH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNFH_ECOLI garnier swissprot:YNFH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNFH_ECOLI helixturnhelix swissprot:YNFH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNFH_ECOLI hmoment swissprot:YNFH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNFH_ECOLI iep swissprot:YNFH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNFH_ECOLI inforesidue swissprot:YNFH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNFH_ECOLI octanol swissprot:YNFH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNFH_ECOLI pepcoil swissprot:YNFH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNFH_ECOLI pepdigest swissprot:YNFH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNFH_ECOLI pepinfo swissprot:YNFH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNFH_ECOLI pepnet swissprot:YNFH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNFH_ECOLI pepstats swissprot:YNFH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNFH_ECOLI pepwheel swissprot:YNFH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNFH_ECOLI pepwindow swissprot:YNFH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNFH_ECOLI sigcleave swissprot:YNFH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNFH_ECOLI ## Database ID URL or Descriptions # AltName PUUA_ECOLI Glutamate--putrescine ligase # BIOPHYSICOCHEMICAL PROPERTIES PUUA_ECOLI Kinetic parameters KM=2.07 mM for glutamate (at pH 8 and at 37 degrees Celsius) {ECO 0000269|PubMed 18495664}; KM=2.25 mM for ATP (at pH 8 and at 37 degrees Celsius) {ECO 0000269|PubMed 18495664}; KM=44.6 mM for putrescine (at pH 8 and at 37 degrees Celsius) {ECO 0000269|PubMed 18495664}; Vmax=6.71 umol/min/mg enzyme (at pH 8 and at 37 degrees Celsius) {ECO 0000269|PubMed 18495664}; pH dependence Optimum pH is 9. {ECO 0000269|PubMed 18495664}; # BioGrid 4260944 8 # CATALYTIC ACTIVITY PUUA_ECOLI ATP + L-glutamate + putrescine = ADP + phosphate + gamma-L-glutamylputrescine. # EcoGene EG13908 puuA # FUNCTION PUUA_ECOLI Involved in the breakdown of putrescine via the biosynthesis of gamma-L-glutamylputrescine. It is able to use several diamines, spermidine and spermine. Absolutely essential to utilize putrescine as both nitrogen and carbon sources and to decrease the toxicity of putrescine, which can lead to inhibition of cell growth and protein synthesis. {ECO 0000269|PubMed 15590624, ECO 0000269|PubMed 18495664}. # GO_function GO:0004356 glutamate-ammonia ligase activity; IEA:InterPro. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0034024 glutamate-putrescine ligase activity; IDA:EcoCyc. # GO_process GO:0006542 glutamine biosynthetic process; IEA:InterPro. # GO_process GO:0009447 putrescine catabolic process; IMP:EcoCyc. # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.10.20.70 -; 1. # Gene3D 3.30.590.10 -; 1. # INDUCTION PUUA_ECOLI Induced by putrescine and repressed by PuuR. Transiently induced by cold shock. {ECO 0000269|PubMed 14527658, ECO 0000269|PubMed 18495664}. # InterPro IPR008146 Gln_synth_cat_dom # InterPro IPR008147 Gln_synt_b-grasp # InterPro IPR014746 Gln_synth/guanido_kin_cat_dom # InterPro IPR027303 Gln_synth_gly_rich_site # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00330 Arginine and proline metabolism # Organism PUUA_ECOLI Escherichia coli (strain K12) # PATHWAY Amine and polyamine degradation; putrescine degradation; 4-aminobutanoate from putrescine step 1/4. # PATRIC 32117864 VBIEscCol129921_1352 # PIR D64878 D64878 # PROSITE PS00181 GLNA_ATP # Pfam PF00120 Gln-synt_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PUUA_ECOLI Gamma-glutamylputrescine synthetase PuuA # RefSeq NP_415813 NC_000913.3 # RefSeq WP_001296746 NZ_LN832404.1 # SIMILARITY Belongs to the glutamine synthetase family. {ECO 0000305}. # SMART SM01230 Gln-synt_C # SUBUNIT Dodecamer. {ECO:0000269|PubMed 18495664}. # SUPFAM SSF54368 SSF54368 # UniPathway UPA00188 UER00880 # eggNOG COG0174 LUCA # eggNOG ENOG4105CFQ Bacteria BLAST swissprot:PUUA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PUUA_ECOLI BioCyc ECOL316407:JW5201-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5201-MONOMER BioCyc EcoCyc:G6644-MONOMER http://biocyc.org/getid?id=EcoCyc:G6644-MONOMER BioCyc MetaCyc:G6644-MONOMER http://biocyc.org/getid?id=MetaCyc:G6644-MONOMER COG COG0174 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0174 DOI 10.1016/S0923-2508(03)00167-0 http://dx.doi.org/10.1016/S0923-2508(03)00167-0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M411114200 http://dx.doi.org/10.1074/jbc.M411114200 DOI 10.1074/jbc.M800133200 http://dx.doi.org/10.1074/jbc.M800133200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.3.1.11 http://www.genome.jp/dbget-bin/www_bget?EC:6.3.1.11 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 6.3.1.11 http://enzyme.expasy.org/EC/6.3.1.11 EchoBASE EB3667 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3667 EcoGene EG13908 http://www.ecogene.org/geneInfo.php?eg_id=EG13908 EnsemblBacteria AAC74379 http://www.ensemblgenomes.org/id/AAC74379 EnsemblBacteria AAC74379 http://www.ensemblgenomes.org/id/AAC74379 EnsemblBacteria BAA14857 http://www.ensemblgenomes.org/id/BAA14857 EnsemblBacteria BAA14857 http://www.ensemblgenomes.org/id/BAA14857 EnsemblBacteria BAA14857 http://www.ensemblgenomes.org/id/BAA14857 EnsemblBacteria b1297 http://www.ensemblgenomes.org/id/b1297 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004356 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004356 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0034024 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034024 GO_process GO:0006542 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006542 GO_process GO:0009447 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009447 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.10.20.70 http://www.cathdb.info/version/latest/superfamily/3.10.20.70 Gene3D 3.30.590.10 http://www.cathdb.info/version/latest/superfamily/3.30.590.10 GeneID 946202 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946202 HOGENOM HOG000005154 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000005154&db=HOGENOM6 InParanoid P78061 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P78061 IntEnz 6.3.1.11 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.1.11 InterPro IPR008146 http://www.ebi.ac.uk/interpro/entry/IPR008146 InterPro IPR008147 http://www.ebi.ac.uk/interpro/entry/IPR008147 InterPro IPR014746 http://www.ebi.ac.uk/interpro/entry/IPR014746 InterPro IPR027303 http://www.ebi.ac.uk/interpro/entry/IPR027303 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5201 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5201 KEGG_Gene eco:b1297 http://www.genome.jp/dbget-bin/www_bget?eco:b1297 KEGG_Orthology KO:K09470 http://www.genome.jp/dbget-bin/www_bget?KO:K09470 KEGG_Pathway ko00330 http://www.genome.jp/kegg-bin/show_pathway?ko00330 KEGG_Reaction rn:R07414 http://www.genome.jp/dbget-bin/www_bget?rn:R07414 OMA AADHNAF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AADHNAF PROSITE PS00181 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00181 PSORT swissprot:PUUA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PUUA_ECOLI PSORT-B swissprot:PUUA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PUUA_ECOLI PSORT2 swissprot:PUUA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PUUA_ECOLI Pfam PF00120 http://pfam.xfam.org/family/PF00120 Phobius swissprot:PUUA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PUUA_ECOLI PhylomeDB P78061 http://phylomedb.org/?seqid=P78061 ProteinModelPortal P78061 http://www.proteinmodelportal.org/query/uniprot/P78061 PubMed 14527658 http://www.ncbi.nlm.nih.gov/pubmed/14527658 PubMed 15590624 http://www.ncbi.nlm.nih.gov/pubmed/15590624 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18495664 http://www.ncbi.nlm.nih.gov/pubmed/18495664 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415813 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415813 RefSeq WP_001296746 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001296746 SMART SM01230 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01230 STRING 511145.b1297 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1297&targetmode=cogs STRING COG0174 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0174&targetmode=cogs SUPFAM SSF54368 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54368 UniProtKB PUUA_ECOLI http://www.uniprot.org/uniprot/PUUA_ECOLI UniProtKB-AC P78061 http://www.uniprot.org/uniprot/P78061 charge swissprot:PUUA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PUUA_ECOLI eggNOG COG0174 http://eggnogapi.embl.de/nog_data/html/tree/COG0174 eggNOG ENOG4105CFQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CFQ epestfind swissprot:PUUA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PUUA_ECOLI garnier swissprot:PUUA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PUUA_ECOLI helixturnhelix swissprot:PUUA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PUUA_ECOLI hmoment swissprot:PUUA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PUUA_ECOLI iep swissprot:PUUA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PUUA_ECOLI inforesidue swissprot:PUUA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PUUA_ECOLI octanol swissprot:PUUA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PUUA_ECOLI pepcoil swissprot:PUUA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PUUA_ECOLI pepdigest swissprot:PUUA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PUUA_ECOLI pepinfo swissprot:PUUA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PUUA_ECOLI pepnet swissprot:PUUA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PUUA_ECOLI pepstats swissprot:PUUA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PUUA_ECOLI pepwheel swissprot:PUUA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PUUA_ECOLI pepwindow swissprot:PUUA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PUUA_ECOLI sigcleave swissprot:PUUA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PUUA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260204 258 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG13802 ydeT # GO_component GO:0009279 cell outer membrane; IBA:GO_Central. # GO_function GO:0015473 fimbrial usher porin activity; IBA:GO_Central. # GO_process GO:0009297 pilus assembly; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0022607 cellular component assembly # InterPro IPR000015 Fimb_usher # InterPro IPR025949 PapC-like_C # Organism YDET_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30451 PTHR30451 # PATRIC 48662326 VBIEscCol107702_1524 # PIR D64904 D64904 # Pfam PF00577 Usher # Pfam PF13953 PapC_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDET_ECOLI Putative uncharacterized protein ydet # eggNOG COG3188 LUCA BLAST swissprot:YDET_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDET_ECOLI BioCyc ECOL316407:JW1499-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1499-MONOMER BioCyc EcoCyc:G6795-MONOMER http://biocyc.org/getid?id=EcoCyc:G6795-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG13802 http://www.ecogene.org/geneInfo.php?eg_id=EG13802 EnsemblBacteria BAA15178 http://www.ensemblgenomes.org/id/BAA15178 EnsemblBacteria BAA15178 http://www.ensemblgenomes.org/id/BAA15178 EnsemblBacteria BAA15178 http://www.ensemblgenomes.org/id/BAA15178 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_function GO:0015473 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015473 GO_process GO:0009297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009297 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 HOGENOM HOG000111414 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000111414&db=HOGENOM6 InParanoid P76137 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76137 InterPro IPR000015 http://www.ebi.ac.uk/interpro/entry/IPR000015 InterPro IPR025949 http://www.ebi.ac.uk/interpro/entry/IPR025949 KEGG_Gene ecj:JW1499 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1499 OMA GAYANTN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GAYANTN PANTHER PTHR30451 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30451 PSORT swissprot:YDET_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDET_ECOLI PSORT-B swissprot:YDET_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDET_ECOLI PSORT2 swissprot:YDET_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDET_ECOLI Pfam PF00577 http://pfam.xfam.org/family/PF00577 Pfam PF13953 http://pfam.xfam.org/family/PF13953 Phobius swissprot:YDET_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDET_ECOLI PhylomeDB P76137 http://phylomedb.org/?seqid=P76137 ProteinModelPortal P76137 http://www.proteinmodelportal.org/query/uniprot/P76137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SMR P76137 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76137 STRING 316407.85674995 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85674995&targetmode=cogs UniProtKB YDET_ECOLI http://www.uniprot.org/uniprot/YDET_ECOLI UniProtKB-AC P76137 http://www.uniprot.org/uniprot/P76137 charge swissprot:YDET_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDET_ECOLI eggNOG COG3188 http://eggnogapi.embl.de/nog_data/html/tree/COG3188 epestfind swissprot:YDET_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDET_ECOLI garnier swissprot:YDET_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDET_ECOLI helixturnhelix swissprot:YDET_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDET_ECOLI hmoment swissprot:YDET_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDET_ECOLI iep swissprot:YDET_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDET_ECOLI inforesidue swissprot:YDET_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDET_ECOLI octanol swissprot:YDET_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDET_ECOLI pepcoil swissprot:YDET_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDET_ECOLI pepdigest swissprot:YDET_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDET_ECOLI pepinfo swissprot:YDET_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDET_ECOLI pepnet swissprot:YDET_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDET_ECOLI pepstats swissprot:YDET_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDET_ECOLI pepwheel swissprot:YDET_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDET_ECOLI pepwindow swissprot:YDET_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDET_ECOLI sigcleave swissprot:YDET_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDET_ECOLI ## Database ID URL or Descriptions # AltName ENVC_ECOLI Septal ring factor # BioGrid 4263303 365 # CAUTION Unlike many members of this family does not have peptidase activity. {ECO:0000305|PubMed 23796240}. # CAUTION Was originally thought to have murein hydrolase activity. {ECO:0000305|PubMed 15165230}. # DISRUPTION PHENOTYPE ENVC_ECOLI Mutants show defects in septation and separation, and form very long filaments (1.5-fold increase). The phenotype is exacerbated when combined with nlpD (over 8-fold longer), more exacerbated with a triple mepM (yebA) or ygeR disruption (15-fold longer) and further yet by the quadruple disruption mutant (envC-nlpD-mepM(yebA)-ygeR, over 21-fold longer). Quadruple mutants are less sensitive to ampicillin lysis. {ECO 0000269|PubMed 11976287, ECO 0000269|PubMed 12113939, ECO 0000269|PubMed 15165230, ECO 0000269|PubMed 19525345}. # DOMAIN ENVC_ECOLI The coiled-coil domain is necessary and sufficient for recruitment to the divisome. The LytM domain is required for proper septal peptidoglycan splitting. {ECO 0000269|PubMed 20300061}. # EcoGene EG12297 envC # FUNCTION ENVC_ECOLI Activator of the cell wall hydrolases AmiA and AmiB. Required for septal murein cleavage and daughter cell separation during cell division. In vitro, exhibits weak endoproteolytic activity on beta-casein. {ECO 0000269|PubMed 11976287, ECO 0000269|PubMed 15165230, ECO 0000269|PubMed 19525345, ECO 0000269|PubMed 20300061, ECO 0000269|PubMed 23796240}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_component GO:0032153 cell division site; IDA:EcoliWiki. # GO_component GO:0042597 periplasmic space; IDA:EcoCyc. # GO_function GO:0016787 hydrolase activity; IDA:EcoliWiki. # GO_process GO:0000920 cell separation after cytokinesis; IMP:EcoliWiki. # GO_process GO:0001896 autolysis; IGI:EcoliWiki. # GO_process GO:0007049 cell cycle; IEA:UniProtKB-KW. # GO_process GO:0009273 peptidoglycan-based cell wall biogenesis; IMP:EcoCyc. # GO_process GO:0042493 response to drug; IMP:EcoCyc. # GO_process GO:0051345 positive regulation of hydrolase activity; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0007049 cell cycle # GOslim_process GO:0008150 biological_process # GOslim_process GO:0008219 cell death # GOslim_process GO:0071554 cell wall organization or biogenesis # InterPro IPR011055 Dup_hybrid_motif # InterPro IPR016047 Peptidase_M23 # Organism ENVC_ECOLI Escherichia coli (strain K12) # PATRIC 32122713 VBIEscCol129921_3733 # PDB 4BH5 X-ray; 1.57 A; A/B/C/D=278-419 # Pfam PF01551 Peptidase_M23 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ENVC_ECOLI Murein hydrolase activator EnvC # RefSeq NP_418070 NC_000913.3 # SEQUENCE CAUTION Sequence=AAB18590.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the peptidase M23B family. {ECO 0000305}. # SUBCELLULAR LOCATION ENVC_ECOLI Periplasm {ECO 0000269|PubMed 12113939, ECO 0000269|PubMed 15165230, ECO 0000269|PubMed 19525345}. Note=Localizes at the septal ring. # SUPFAM SSF51261 SSF51261 # eggNOG COG4942 LUCA # eggNOG ENOG41063SB Bacteria BLAST swissprot:ENVC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ENVC_ECOLI BioCyc ECOL316407:JW5646-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5646-MONOMER BioCyc EcoCyc:EG12297-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12297-MONOMER BioCyc MetaCyc:EG12297-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12297-MONOMER DIP DIP-12426N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12426N DOI 10.1038/emboj.2010.36 http://dx.doi.org/10.1038/emboj.2010.36 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1111/j.1365-2958.2004.04063.x http://dx.doi.org/10.1111/j.1365-2958.2004.04063.x DOI 10.1111/j.1574-6968.2002.tb11271.x http://dx.doi.org/10.1111/j.1574-6968.2002.tb11271.x DOI 10.1111/mmi.12304 http://dx.doi.org/10.1111/mmi.12304 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00505-09 http://dx.doi.org/10.1128/JB.00505-09 DOI 10.1128/JB.184.10.2595-2602.2002 http://dx.doi.org/10.1128/JB.184.10.2595-2602.2002 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2205 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2205 EcoGene EG12297 http://www.ecogene.org/geneInfo.php?eg_id=EG12297 EnsemblBacteria AAC76637 http://www.ensemblgenomes.org/id/AAC76637 EnsemblBacteria AAC76637 http://www.ensemblgenomes.org/id/AAC76637 EnsemblBacteria BAE77679 http://www.ensemblgenomes.org/id/BAE77679 EnsemblBacteria BAE77679 http://www.ensemblgenomes.org/id/BAE77679 EnsemblBacteria BAE77679 http://www.ensemblgenomes.org/id/BAE77679 EnsemblBacteria b3613 http://www.ensemblgenomes.org/id/b3613 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_component GO:0032153 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032153 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0016787 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016787 GO_process GO:0000920 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000920 GO_process GO:0001896 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001896 GO_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GO_process GO:0009273 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009273 GO_process GO:0042493 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493 GO_process GO:0051345 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051345 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0008219 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008219 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 GeneID 948129 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948129 HOGENOM HOG000270189 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000270189&db=HOGENOM6 InParanoid P37690 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37690 InterPro IPR011055 http://www.ebi.ac.uk/interpro/entry/IPR011055 InterPro IPR016047 http://www.ebi.ac.uk/interpro/entry/IPR016047 KEGG_Gene ecj:JW5646 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5646 KEGG_Gene eco:b3613 http://www.genome.jp/dbget-bin/www_bget?eco:b3613 OMA PEKFART http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PEKFART PDB 4BH5 http://www.ebi.ac.uk/pdbe-srv/view/entry/4BH5 PDBsum 4BH5 http://www.ebi.ac.uk/pdbsum/4BH5 PSORT swissprot:ENVC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ENVC_ECOLI PSORT-B swissprot:ENVC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ENVC_ECOLI PSORT2 swissprot:ENVC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ENVC_ECOLI Pfam PF01551 http://pfam.xfam.org/family/PF01551 Phobius swissprot:ENVC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ENVC_ECOLI PhylomeDB P37690 http://phylomedb.org/?seqid=P37690 ProteinModelPortal P37690 http://www.proteinmodelportal.org/query/uniprot/P37690 PubMed 11976287 http://www.ncbi.nlm.nih.gov/pubmed/11976287 PubMed 12113939 http://www.ncbi.nlm.nih.gov/pubmed/12113939 PubMed 15165230 http://www.ncbi.nlm.nih.gov/pubmed/15165230 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19525345 http://www.ncbi.nlm.nih.gov/pubmed/19525345 PubMed 20300061 http://www.ncbi.nlm.nih.gov/pubmed/20300061 PubMed 23796240 http://www.ncbi.nlm.nih.gov/pubmed/23796240 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418070 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418070 SMR P37690 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37690 STRING 511145.b3613 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3613&targetmode=cogs SUPFAM SSF51261 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51261 UniProtKB ENVC_ECOLI http://www.uniprot.org/uniprot/ENVC_ECOLI UniProtKB-AC P37690 http://www.uniprot.org/uniprot/P37690 charge swissprot:ENVC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ENVC_ECOLI eggNOG COG4942 http://eggnogapi.embl.de/nog_data/html/tree/COG4942 eggNOG ENOG41063SB http://eggnogapi.embl.de/nog_data/html/tree/ENOG41063SB epestfind swissprot:ENVC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ENVC_ECOLI garnier swissprot:ENVC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ENVC_ECOLI helixturnhelix swissprot:ENVC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ENVC_ECOLI hmoment swissprot:ENVC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ENVC_ECOLI iep swissprot:ENVC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ENVC_ECOLI inforesidue swissprot:ENVC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ENVC_ECOLI octanol swissprot:ENVC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ENVC_ECOLI pepcoil swissprot:ENVC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ENVC_ECOLI pepdigest swissprot:ENVC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ENVC_ECOLI pepinfo swissprot:ENVC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ENVC_ECOLI pepnet swissprot:ENVC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ENVC_ECOLI pepstats swissprot:ENVC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ENVC_ECOLI pepwheel swissprot:ENVC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ENVC_ECOLI pepwindow swissprot:ENVC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ENVC_ECOLI sigcleave swissprot:ENVC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ENVC_ECOLI ## Database ID URL or Descriptions # BRENDA 3.1.4.17 2026 # BioGrid 4262394 12 # EcoGene EG12186 yqiA # FUNCTION YQIA_ECOLI Displays esterase activity toward palmitoyl-CoA and pNP- butyrate. {ECO 0000269|PubMed 15808744}. # GO_function GO:0016788 hydrolase activity, acting on ester bonds; IDA:EcoCyc. # GO_function GO:0052689 carboxylic ester hydrolase activity; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # Gene3D 3.40.50.1820 -; 1. # InterPro IPR008886 UPF0227/Esterase_YqiA # InterPro IPR029058 AB_hydrolase # Organism YQIA_ECOLI Escherichia coli (strain K12) # PATRIC 32121472 VBIEscCol129921_3123 # PIR D58723 D58723 # PIR E65090 E65090 # Pfam PF05728 UPF0227 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQIA_ECOLI Esterase YqiA # RefSeq NP_417503 NC_000913.3 # RefSeq WP_000105733 NZ_LN832404.1 # SUPFAM SSF53474 SSF53474 # eggNOG COG3150 LUCA # eggNOG ENOG4105IPS Bacteria BLAST swissprot:YQIA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQIA_ECOLI BioCyc ECOL316407:JW2999-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2999-MONOMER BioCyc EcoCyc:G7578-MONOMER http://biocyc.org/getid?id=EcoCyc:G7578-MONOMER COG COG3150 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3150 DOI 10.1016/j.fmrre.2004.12.006 http://dx.doi.org/10.1016/j.fmrre.2004.12.006 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.271.41.25423 http://dx.doi.org/10.1074/jbc.271.41.25423 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D16557 http://www.ebi.ac.uk/ena/data/view/D16557 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 ENZYME 3.1.-.- http://enzyme.expasy.org/EC/3.1.-.- EchoBASE EB2103 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2103 EcoGene EG12186 http://www.ecogene.org/geneInfo.php?eg_id=EG12186 EnsemblBacteria AAC76067 http://www.ensemblgenomes.org/id/AAC76067 EnsemblBacteria AAC76067 http://www.ensemblgenomes.org/id/AAC76067 EnsemblBacteria BAE77087 http://www.ensemblgenomes.org/id/BAE77087 EnsemblBacteria BAE77087 http://www.ensemblgenomes.org/id/BAE77087 EnsemblBacteria BAE77087 http://www.ensemblgenomes.org/id/BAE77087 EnsemblBacteria b3031 http://www.ensemblgenomes.org/id/b3031 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016788 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016788 GO_function GO:0052689 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052689 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 Gene3D 3.40.50.1820 http://www.cathdb.info/version/latest/superfamily/3.40.50.1820 GeneID 947488 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947488 HOGENOM HOG000256044 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000256044&db=HOGENOM6 InParanoid P0A8Z7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8Z7 IntAct P0A8Z7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8Z7* IntEnz 3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1 InterPro IPR008886 http://www.ebi.ac.uk/interpro/entry/IPR008886 InterPro IPR029058 http://www.ebi.ac.uk/interpro/entry/IPR029058 KEGG_Gene ecj:JW2999 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2999 KEGG_Gene eco:b3031 http://www.genome.jp/dbget-bin/www_bget?eco:b3031 KEGG_Orthology KO:K07000 http://www.genome.jp/dbget-bin/www_bget?KO:K07000 OMA MLAHYPG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MLAHYPG PSORT swissprot:YQIA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQIA_ECOLI PSORT-B swissprot:YQIA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQIA_ECOLI PSORT2 swissprot:YQIA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQIA_ECOLI Pfam PF05728 http://pfam.xfam.org/family/PF05728 Phobius swissprot:YQIA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQIA_ECOLI ProteinModelPortal P0A8Z7 http://www.proteinmodelportal.org/query/uniprot/P0A8Z7 PubMed 15808744 http://www.ncbi.nlm.nih.gov/pubmed/15808744 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8810311 http://www.ncbi.nlm.nih.gov/pubmed/8810311 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417503 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417503 RefSeq WP_000105733 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000105733 SMR P0A8Z7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8Z7 STRING 511145.b3031 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3031&targetmode=cogs STRING COG3150 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3150&targetmode=cogs SUPFAM SSF53474 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53474 UniProtKB YQIA_ECOLI http://www.uniprot.org/uniprot/YQIA_ECOLI UniProtKB-AC P0A8Z7 http://www.uniprot.org/uniprot/P0A8Z7 charge swissprot:YQIA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQIA_ECOLI eggNOG COG3150 http://eggnogapi.embl.de/nog_data/html/tree/COG3150 eggNOG ENOG4105IPS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105IPS epestfind swissprot:YQIA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQIA_ECOLI garnier swissprot:YQIA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQIA_ECOLI helixturnhelix swissprot:YQIA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQIA_ECOLI hmoment swissprot:YQIA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQIA_ECOLI iep swissprot:YQIA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQIA_ECOLI inforesidue swissprot:YQIA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQIA_ECOLI octanol swissprot:YQIA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQIA_ECOLI pepcoil swissprot:YQIA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQIA_ECOLI pepdigest swissprot:YQIA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQIA_ECOLI pepinfo swissprot:YQIA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQIA_ECOLI pepnet swissprot:YQIA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQIA_ECOLI pepstats swissprot:YQIA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQIA_ECOLI pepwheel swissprot:YQIA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQIA_ECOLI pepwindow swissprot:YQIA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQIA_ECOLI sigcleave swissprot:YQIA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQIA_ECOLI ## Database ID URL or Descriptions # AltName SCPB_ECOLI Transcarboxylase # BioGrid 4259438 2 # CATALYTIC ACTIVITY (S)-methylmalonyl-CoA = propanoyl-CoA + CO(2). {ECO:0000269|PubMed 10769117}. # EcoGene EG12972 scpB # FUNCTION SCPB_ECOLI Catalyzes the decarboxylation of methylmalonyl-CoA to propionyl-CoA. Could be part of a pathway that converts succinate to propionate. {ECO 0000269|PubMed 10769117}. # GO_component GO:0005829 cytosol; ISS:UniProtKB. # GO_function GO:0004300 enoyl-CoA hydratase activity; IBA:GO_Central. # GO_function GO:0004492 methylmalonyl-CoA decarboxylase activity; IDA:EcoCyc. # GO_function GO:0016831 carboxy-lyase activity; ISS:UniProtKB. # GO_process GO:0006635 fatty acid beta-oxidation; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.12.10 -; 1. # Gene3D 3.90.226.10 -; 1. # InterPro IPR001753 Crotonase_core_superfam # InterPro IPR014748 Crontonase_C # InterPro IPR018376 Enoyl-CoA_hyd/isom_CS # InterPro IPR029045 ClpP/crotonase-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00640 Propanoate metabolism # Organism SCPB_ECOLI Escherichia coli (strain K12) # PATRIC 32121252 VBIEscCol129921_3014 # PDB 1EF8 X-ray; 1.85 A; A/B/C=1-261 # PDB 1EF9 X-ray; 2.70 A; A=1-261 # PROSITE PS00166 ENOYL_COA_HYDRATASE # Pfam PF00378 ECH_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SCPB_ECOLI Methylmalonyl-CoA decarboxylase # RefSeq NP_417394 NC_000913.3 # RefSeq WP_000122080 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA69086.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the enoyl-CoA hydratase/isomerase family. {ECO 0000305}. # SUBUNIT Dimer of homotrimers. {ECO:0000269|PubMed 10769118}. # SUPFAM SSF52096 SSF52096 # eggNOG COG1024 LUCA # eggNOG ENOG4108M7F Bacteria BLAST swissprot:SCPB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SCPB_ECOLI BioCyc ECOL316407:JW2886-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2886-MONOMER BioCyc EcoCyc:G7516-MONOMER http://biocyc.org/getid?id=EcoCyc:G7516-MONOMER BioCyc MetaCyc:G7516-MONOMER http://biocyc.org/getid?id=MetaCyc:G7516-MONOMER COG COG1024 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1024 DOI 10.1021/bi992888d http://dx.doi.org/10.1021/bi992888d DOI 10.1021/bi9928896 http://dx.doi.org/10.1021/bi9928896 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.1.1.41 http://www.genome.jp/dbget-bin/www_bget?EC:4.1.1.41 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 ENZYME 4.1.1.41 http://enzyme.expasy.org/EC/4.1.1.41 EchoBASE EB2799 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2799 EcoGene EG12972 http://www.ecogene.org/geneInfo.php?eg_id=EG12972 EnsemblBacteria AAC75956 http://www.ensemblgenomes.org/id/AAC75956 EnsemblBacteria AAC75956 http://www.ensemblgenomes.org/id/AAC75956 EnsemblBacteria BAE76983 http://www.ensemblgenomes.org/id/BAE76983 EnsemblBacteria BAE76983 http://www.ensemblgenomes.org/id/BAE76983 EnsemblBacteria BAE76983 http://www.ensemblgenomes.org/id/BAE76983 EnsemblBacteria b2919 http://www.ensemblgenomes.org/id/b2919 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004300 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004300 GO_function GO:0004492 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004492 GO_function GO:0016831 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016831 GO_process GO:0006635 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006635 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.12.10 http://www.cathdb.info/version/latest/superfamily/1.10.12.10 Gene3D 3.90.226.10 http://www.cathdb.info/version/latest/superfamily/3.90.226.10 GeneID 947408 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947408 HOGENOM HOG000027939 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000027939&db=HOGENOM6 InParanoid P52045 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P52045 IntEnz 4.1.1.41 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.1.41 InterPro IPR001753 http://www.ebi.ac.uk/interpro/entry/IPR001753 InterPro IPR014748 http://www.ebi.ac.uk/interpro/entry/IPR014748 InterPro IPR018376 http://www.ebi.ac.uk/interpro/entry/IPR018376 InterPro IPR029045 http://www.ebi.ac.uk/interpro/entry/IPR029045 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2886 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2886 KEGG_Gene eco:b2919 http://www.genome.jp/dbget-bin/www_bget?eco:b2919 KEGG_Orthology KO:K11264 http://www.genome.jp/dbget-bin/www_bget?KO:K11264 KEGG_Pathway ko00640 http://www.genome.jp/kegg-bin/show_pathway?ko00640 KEGG_Reaction rn:R00923 http://www.genome.jp/dbget-bin/www_bget?rn:R00923 OMA VNVVIIQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VNVVIIQ PDB 1EF8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1EF8 PDB 1EF9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1EF9 PDBsum 1EF8 http://www.ebi.ac.uk/pdbsum/1EF8 PDBsum 1EF9 http://www.ebi.ac.uk/pdbsum/1EF9 PROSITE PS00166 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00166 PSORT swissprot:SCPB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SCPB_ECOLI PSORT-B swissprot:SCPB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SCPB_ECOLI PSORT2 swissprot:SCPB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SCPB_ECOLI Pfam PF00378 http://pfam.xfam.org/family/PF00378 Phobius swissprot:SCPB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SCPB_ECOLI PhylomeDB P52045 http://phylomedb.org/?seqid=P52045 ProteinModelPortal P52045 http://www.proteinmodelportal.org/query/uniprot/P52045 PubMed 10769117 http://www.ncbi.nlm.nih.gov/pubmed/10769117 PubMed 10769118 http://www.ncbi.nlm.nih.gov/pubmed/10769118 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417394 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417394 RefSeq WP_000122080 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000122080 SMR P52045 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P52045 STRING 511145.b2919 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2919&targetmode=cogs STRING COG1024 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1024&targetmode=cogs SUPFAM SSF52096 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52096 UniProtKB SCPB_ECOLI http://www.uniprot.org/uniprot/SCPB_ECOLI UniProtKB-AC P52045 http://www.uniprot.org/uniprot/P52045 charge swissprot:SCPB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SCPB_ECOLI eggNOG COG1024 http://eggnogapi.embl.de/nog_data/html/tree/COG1024 eggNOG ENOG4108M7F http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108M7F epestfind swissprot:SCPB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SCPB_ECOLI garnier swissprot:SCPB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SCPB_ECOLI helixturnhelix swissprot:SCPB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SCPB_ECOLI hmoment swissprot:SCPB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SCPB_ECOLI iep swissprot:SCPB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SCPB_ECOLI inforesidue swissprot:SCPB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SCPB_ECOLI octanol swissprot:SCPB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SCPB_ECOLI pepcoil swissprot:SCPB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SCPB_ECOLI pepdigest swissprot:SCPB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SCPB_ECOLI pepinfo swissprot:SCPB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SCPB_ECOLI pepnet swissprot:SCPB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SCPB_ECOLI pepstats swissprot:SCPB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SCPB_ECOLI pepwheel swissprot:SCPB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SCPB_ECOLI pepwindow swissprot:SCPB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SCPB_ECOLI sigcleave swissprot:SCPB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SCPB_ECOLI ## Database ID URL or Descriptions # AltName Enzyme I-Ntr {ECO:0000303|PubMed 8973315} # AltName Phosphotransferase system, enzyme I {ECO:0000303|PubMed 8973315} # BIOPHYSICOCHEMICAL PROPERTIES PT1P_ECOLI Kinetic parameters KM=10 uM for mannitol phosphate {ECO 0000269|PubMed 10473571}; Vmax=1 umol/min/mg enzyme {ECO 0000269|PubMed 10473571}; Note=Enzyme I-Ntr activity requires high ionic strength. {ECO 0000269|PubMed 10473571}; pH dependence Optimum pH is 8. {ECO 0000269|PubMed 10473571}; # BioGrid 4263274 24 # CATALYTIC ACTIVITY Phosphoenolpyruvate + protein L-histidine = pyruvate + protein N(pi)-phospho-L-histidine. {ECO:0000269|PubMed 10473571}. # COFACTOR PT1P_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 10473571}; Note=Mn(2+) allows activity only at low concentrations. In the presence of low concentrations of Co(2+) or Ni(2+), activity could be measured, but at concentrations above 0.2 mM, strong inhibition is observed. {ECO 0000269|PubMed 10473571}; # DOMAIN PT1P_ECOLI The EI N-terminal domain contains the HPr binding site, the central domain the pyrophosphate/phosphate carrier histidine, and the C-terminal domain the pyruvate binding site. {ECO 0000250|UniProtKB P08839}. # DOMAIN PT1P_ECOLI The GAF domain is an important site of signal perception in prokaryotes and eukaryotes. {ECO 0000305}. # ENZYME REGULATION Inhibited by GDP and FAD. {ECO:0000269|PubMed 10473571}. # EcoGene EG12188 ptsP # FUNCTION PT1P_ECOLI Component of the phosphoenolpyruvate-dependent nitrogen- metabolic phosphotransferase system (nitrogen-metabolic PTS), that seems to be involved in regulating nitrogen metabolism. Enzyme I- Ntr transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (NPr) (PubMed 10473571). Could function in the transcriptional regulation of sigma-54 dependent operons in conjunction with the NPr (PtsO) and EIIA-Ntr (PtsN) proteins (PubMed 8973315). Enzyme I-Ntr is specific for NPr (PubMed 10473571). {ECO 0000269|PubMed 10473571, ECO 0000269|PubMed 8973315}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0008965 phosphoenolpyruvate-protein phosphotransferase activity; IDA:EcoCyc. # GO_function GO:0016301 kinase activity; IEA:UniProtKB-KW. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006468 protein phosphorylation; IDA:EcoCyc. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW. # GO_process GO:0010243 response to organonitrogen compound; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # Gene3D 1.10.274.10 -; 1. # Gene3D 3.20.20.60 -; 1. # Gene3D 3.30.450.40 -; 1. # Gene3D 3.50.30.10 -; 1. # IntAct P37177 10 # InterPro IPR000121 PEP_util_C # InterPro IPR003018 GAF # InterPro IPR006318 PTS_EI-like # InterPro IPR008279 PEP-util_enz_mobile_dom # InterPro IPR008731 PTS_EIN # InterPro IPR015813 Pyrv/PenolPyrv_Kinase-like_dom # InterPro IPR018274 PEP_util_AS # InterPro IPR023151 PEP_util_CS # InterPro IPR029016 GAF_dom-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02060 Phosphotransferase system (PTS) # MISCELLANEOUS The reaction takes place in three steps, mediated by a phosphocarrier histidine residue located on the surface of the central domain. The two first partial reactions are catalyzed at an active site located on the N-terminal domain, and the third partial reaction is catalyzed at an active site located on the C- terminal domain. For catalytic turnover, the central domain swivels from the concave surface of the N-terminal domain to that of the C-terminal domain. {ECO:0000250|UniProtKB P08839}. # Organism PT1P_ECOLI Escherichia coli (strain K12) # PATRIC 32121076 VBIEscCol129921_2927 # PIR F65065 F65065 # PROSITE PS00370 PEP_ENZYMES_PHOS_SITE # PROSITE PS00742 PEP_ENZYMES_2 # Pfam PF00391 PEP-utilizers # Pfam PF01590 GAF # Pfam PF02896 PEP-utilizers_C # Pfam PF05524 PEP-utilisers_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Phosphoenolpyruvate-dependent phosphotransferase system {ECO:0000303|PubMed 8973315} # RefSeq NP_417306 NC_000913.3 # RefSeq WP_000957910 NZ_LN832404.1 # SIMILARITY Belongs to the PEP-utilizing enzyme family. {ECO 0000305}. # SIMILARITY Contains 1 GAF domain. {ECO:0000305|PubMed 8973315}. # SMART SM00065 GAF # SUBCELLULAR LOCATION PT1P_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF47831 SSF47831 # SUPFAM SSF51621 SSF51621 # SUPFAM SSF52009 SSF52009 # SUPFAM SSF55781 SSF55781 # TIGRFAMs TIGR01417 PTS_I_fam # eggNOG COG3605 LUCA # eggNOG ENOG4108HRM Bacteria BLAST swissprot:PT1P_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PT1P_ECOLI BioCyc ECOL316407:JW2797-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2797-MONOMER BioCyc EcoCyc:EG12188-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12188-MONOMER COG COG3605 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3605 DOI 10.1016/S0378-1119(96)00481-7 http://dx.doi.org/10.1016/S0378-1119(96)00481-7 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.274.37.26185 http://dx.doi.org/10.1074/jbc.274.37.26185 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.3.9 {ECO:0000269|PubMed:10473571} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.3.9 {ECO:0000269|PubMed:10473571} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U12289 http://www.ebi.ac.uk/ena/data/view/U12289 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 ENZYME 2.7.3.9 {ECO:0000269|PubMed:10473571} http://enzyme.expasy.org/EC/2.7.3.9 {ECO:0000269|PubMed:10473571} EchoBASE EB2105 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2105 EcoGene EG12188 http://www.ecogene.org/geneInfo.php?eg_id=EG12188 EnsemblBacteria AAC75868 http://www.ensemblgenomes.org/id/AAC75868 EnsemblBacteria AAC75868 http://www.ensemblgenomes.org/id/AAC75868 EnsemblBacteria BAE76898 http://www.ensemblgenomes.org/id/BAE76898 EnsemblBacteria BAE76898 http://www.ensemblgenomes.org/id/BAE76898 EnsemblBacteria BAE76898 http://www.ensemblgenomes.org/id/BAE76898 EnsemblBacteria b2829 http://www.ensemblgenomes.org/id/b2829 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0008965 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008965 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006468 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006468 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GO_process GO:0010243 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010243 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.10.274.10 http://www.cathdb.info/version/latest/superfamily/1.10.274.10 Gene3D 3.20.20.60 http://www.cathdb.info/version/latest/superfamily/3.20.20.60 Gene3D 3.30.450.40 http://www.cathdb.info/version/latest/superfamily/3.30.450.40 Gene3D 3.50.30.10 http://www.cathdb.info/version/latest/superfamily/3.50.30.10 GeneID 947301 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947301 HOGENOM HOG000278514 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278514&db=HOGENOM6 InParanoid P37177 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37177 IntAct P37177 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37177* IntEnz 2.7.3.9 {ECO:0000269|PubMed:10473571} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.3.9 {ECO:0000269|PubMed:10473571} InterPro IPR000121 http://www.ebi.ac.uk/interpro/entry/IPR000121 InterPro IPR003018 http://www.ebi.ac.uk/interpro/entry/IPR003018 InterPro IPR006318 http://www.ebi.ac.uk/interpro/entry/IPR006318 InterPro IPR008279 http://www.ebi.ac.uk/interpro/entry/IPR008279 InterPro IPR008731 http://www.ebi.ac.uk/interpro/entry/IPR008731 InterPro IPR015813 http://www.ebi.ac.uk/interpro/entry/IPR015813 InterPro IPR018274 http://www.ebi.ac.uk/interpro/entry/IPR018274 InterPro IPR023151 http://www.ebi.ac.uk/interpro/entry/IPR023151 InterPro IPR029016 http://www.ebi.ac.uk/interpro/entry/IPR029016 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2797 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2797 KEGG_Gene eco:b2829 http://www.genome.jp/dbget-bin/www_bget?eco:b2829 KEGG_Orthology KO:K08484 http://www.genome.jp/dbget-bin/www_bget?KO:K08484 KEGG_Pathway ko02060 http://www.genome.jp/kegg-bin/show_pathway?ko02060 OMA MFPMISE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MFPMISE PROSITE PS00370 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00370 PROSITE PS00742 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00742 PSORT swissprot:PT1P_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PT1P_ECOLI PSORT-B swissprot:PT1P_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PT1P_ECOLI PSORT2 swissprot:PT1P_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PT1P_ECOLI Pfam PF00391 http://pfam.xfam.org/family/PF00391 Pfam PF01590 http://pfam.xfam.org/family/PF01590 Pfam PF02896 http://pfam.xfam.org/family/PF02896 Pfam PF05524 http://pfam.xfam.org/family/PF05524 Phobius swissprot:PT1P_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PT1P_ECOLI PhylomeDB P37177 http://phylomedb.org/?seqid=P37177 ProteinModelPortal P37177 http://www.proteinmodelportal.org/query/uniprot/P37177 PubMed 10473571 http://www.ncbi.nlm.nih.gov/pubmed/10473571 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7896715 http://www.ncbi.nlm.nih.gov/pubmed/7896715 PubMed 8973315 http://www.ncbi.nlm.nih.gov/pubmed/8973315 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417306 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417306 RefSeq WP_000957910 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000957910 SMART SM00065 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00065 SMR P37177 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37177 STRING 511145.b2829 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2829&targetmode=cogs STRING COG3605 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3605&targetmode=cogs SUPFAM SSF47831 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47831 SUPFAM SSF51621 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51621 SUPFAM SSF52009 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52009 SUPFAM SSF55781 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55781 TIGRFAMs TIGR01417 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01417 UniProtKB PT1P_ECOLI http://www.uniprot.org/uniprot/PT1P_ECOLI UniProtKB-AC P37177 http://www.uniprot.org/uniprot/P37177 charge swissprot:PT1P_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PT1P_ECOLI eggNOG COG3605 http://eggnogapi.embl.de/nog_data/html/tree/COG3605 eggNOG ENOG4108HRM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108HRM epestfind swissprot:PT1P_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PT1P_ECOLI garnier swissprot:PT1P_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PT1P_ECOLI helixturnhelix swissprot:PT1P_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PT1P_ECOLI hmoment swissprot:PT1P_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PT1P_ECOLI iep swissprot:PT1P_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PT1P_ECOLI inforesidue swissprot:PT1P_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PT1P_ECOLI octanol swissprot:PT1P_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PT1P_ECOLI pepcoil swissprot:PT1P_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PT1P_ECOLI pepdigest swissprot:PT1P_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PT1P_ECOLI pepinfo swissprot:PT1P_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PT1P_ECOLI pepnet swissprot:PT1P_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PT1P_ECOLI pepstats swissprot:PT1P_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PT1P_ECOLI pepwheel swissprot:PT1P_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PT1P_ECOLI pepwindow swissprot:PT1P_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PT1P_ECOLI sigcleave swissprot:PT1P_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PT1P_ECOLI ## Database ID URL or Descriptions # AltName HOKC_ECOLI Protein gef # BioGrid 4259470 3 # EcoGene EG10373 hokC # FUNCTION HOKC_ECOLI When overexpressed, kills the cells from the inside by interfering with a vital function in the cell membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_component GO:0042597 periplasmic space; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR000021 Hok/gef_toxin # InterPro IPR018084 Hok/gef_toxin_CS # Organism HOKC_ECOLI Escherichia coli (strain K12) # PATRIC 32115127 VBIEscCol129921_0015 # PRINTS PR00281 HOKGEFTOXIC # PROSITE PS00556 HOK_GEF # Pfam PF01848 HOK_GEF # ProDom PD005979 Hok/gef_toxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HOKC_ECOLI Protein HokC # RefSeq WP_000809168 NZ_LN832404.1 # RefSeq YP_025292 NC_000913.3 # SIMILARITY Belongs to the hok/gef family. {ECO 0000305}. # SUBCELLULAR LOCATION HOKC_ECOLI Cell inner membrane; Single-pass type II membrane protein. # SUBUNIT HOKC_ECOLI Homodimer; disulfide-linked. # TCDB 1.E.53.1 the toxic hok/gef protein (hok/gef) family # eggNOG ENOG41123E9 LUCA BLAST swissprot:HOKC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HOKC_ECOLI BioCyc ECOL316407:JW5002-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5002-MONOMER BioCyc EcoCyc:MONOMER0-1564 http://biocyc.org/getid?id=EcoCyc:MONOMER0-1564 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1999.01431.x http://dx.doi.org/10.1046/j.1365-2958.1999.01431.x DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1111/j.1365-2958.1989.tb00131.x http://dx.doi.org/10.1111/j.1365-2958.1989.tb00131.x DOI 10.1111/j.1365-2958.1991.tb01910.x http://dx.doi.org/10.1111/j.1365-2958.1991.tb01910.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X17311 http://www.ebi.ac.uk/ena/data/view/X17311 EchoBASE EB0368 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0368 EcoGene EG10373 http://www.ecogene.org/geneInfo.php?eg_id=EG10373 EnsemblBacteria AAT48122 http://www.ensemblgenomes.org/id/AAT48122 EnsemblBacteria AAT48122 http://www.ensemblgenomes.org/id/AAT48122 EnsemblBacteria BAE76031 http://www.ensemblgenomes.org/id/BAE76031 EnsemblBacteria BAE76031 http://www.ensemblgenomes.org/id/BAE76031 EnsemblBacteria BAE76031 http://www.ensemblgenomes.org/id/BAE76031 EnsemblBacteria b4412 http://www.ensemblgenomes.org/id/b4412 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 2847744 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2847744 HOGENOM HOG000041219 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000041219&db=HOGENOM6 InterPro IPR000021 http://www.ebi.ac.uk/interpro/entry/IPR000021 InterPro IPR018084 http://www.ebi.ac.uk/interpro/entry/IPR018084 KEGG_Gene ecj:JW5002 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5002 KEGG_Gene eco:b4412 http://www.genome.jp/dbget-bin/www_bget?eco:b4412 PRINTS PR00281 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00281 PROSITE PS00556 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00556 PSORT swissprot:HOKC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HOKC_ECOLI PSORT-B swissprot:HOKC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HOKC_ECOLI PSORT2 swissprot:HOKC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HOKC_ECOLI Pfam PF01848 http://pfam.xfam.org/family/PF01848 Phobius swissprot:HOKC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HOKC_ECOLI PhylomeDB P0ACG4 http://phylomedb.org/?seqid=P0ACG4 ProteinModelPortal P0ACG4 http://www.proteinmodelportal.org/query/uniprot/P0ACG4 PubMed 10361310 http://www.ncbi.nlm.nih.gov/pubmed/10361310 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1943700 http://www.ncbi.nlm.nih.gov/pubmed/1943700 PubMed 2693900 http://www.ncbi.nlm.nih.gov/pubmed/2693900 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000809168 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000809168 RefSeq YP_025292 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_025292 STRING 511145.b4412 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4412&targetmode=cogs TCDB 1.E.53.1 http://www.tcdb.org/search/result.php?tc=1.E.53.1 UniProtKB HOKC_ECOLI http://www.uniprot.org/uniprot/HOKC_ECOLI UniProtKB-AC P0ACG4 http://www.uniprot.org/uniprot/P0ACG4 charge swissprot:HOKC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HOKC_ECOLI eggNOG ENOG41123E9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41123E9 epestfind swissprot:HOKC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HOKC_ECOLI garnier swissprot:HOKC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HOKC_ECOLI helixturnhelix swissprot:HOKC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HOKC_ECOLI hmoment swissprot:HOKC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HOKC_ECOLI iep swissprot:HOKC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HOKC_ECOLI inforesidue swissprot:HOKC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HOKC_ECOLI octanol swissprot:HOKC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HOKC_ECOLI pepcoil swissprot:HOKC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HOKC_ECOLI pepdigest swissprot:HOKC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HOKC_ECOLI pepinfo swissprot:HOKC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HOKC_ECOLI pepnet swissprot:HOKC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HOKC_ECOLI pepstats swissprot:HOKC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HOKC_ECOLI pepwheel swissprot:HOKC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HOKC_ECOLI pepwindow swissprot:HOKC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HOKC_ECOLI sigcleave swissprot:HOKC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HOKC_ECOLI ## Database ID URL or Descriptions # AltName GLTD_ECOLI Glutamate synthase subunit beta # AltName GLTD_ECOLI NADPH-GOGAT # BRENDA 1.4.1.13 2026 # BioGrid 4262427 185 # CATALYTIC ACTIVITY GLTD_ECOLI 2 L-glutamate + NADP(+) = L-glutamine + 2- oxoglutarate + NADPH. # COFACTOR Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI 49883; Note=Binds 1 [4Fe-4S] cluster.; # EcoGene EG10404 gltD # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004355 glutamate synthase (NADPH) activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0006537 glutamate biosynthetic process; IDA:EcoCyc. # GO_process GO:0008652 cellular amino acid biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0097054 L-glutamate biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.720 -; 2. # Gene3D 3.50.50.60 -; 1. # INTERACTION GLTD_ECOLI P09831 gltB; NbExp=2; IntAct=EBI-544293, EBI-551179; # IntAct P09832 6 # InterPro IPR006006 Glut_synth_ssu2 # InterPro IPR009051 Helical_ferredxn # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR017896 4Fe4S_Fe-S-bd # InterPro IPR023753 FAD/NAD-binding_dom # InterPro IPR028261 DPD_II # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00250 Alanine, aspartate and glutamate metabolism # KEGG_Pathway ko00910 Nitrogen metabolism # MISCELLANEOUS GLTD_ECOLI Glutamine binds to the large subunit and transfers the amido group to 2-oxo-glutamate that apparently binds to the small subunit. # Organism GLTD_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-glutamate biosynthesis via GLT pathway; L-glutamate from 2-oxoglutarate and L-glutamine (NADP(+) route) step 1/1. # PATHWAY GLTD_ECOLI Energy metabolism; nitrogen metabolism. # PATRIC 32121848 VBIEscCol129921_3308 # PIR G65112 G65112 # PROSITE PS51379 4FE4S_FER_2 # Pfam PF07992 Pyr_redox_2 # Pfam PF14691 Fer4_20 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLTD_ECOLI Glutamate synthase [NADPH] small chain # RefSeq NP_417680 NC_000913.3 # RefSeq WP_000081674 NZ_LN832404.1 # SIMILARITY Contains 1 4Fe-4S ferredoxin-type domain. {ECO:0000255|PROSITE-ProRule PRU00711}. # SUBUNIT GLTD_ECOLI Aggregate of 4 catalytic active heterodimers, consisting of a large and a small subunit. # SUPFAM SSF46548 SSF46548 # TIGRFAMs TIGR01318 gltD_gamma_fam # UniPathway UPA00634 UER00689 # eggNOG COG0493 LUCA # eggNOG ENOG4105BZ8 Bacteria BLAST swissprot:GLTD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLTD_ECOLI BioCyc ECOL316407:JW3180-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3180-MONOMER BioCyc EcoCyc:GLUSYNSMALL-MONOMER http://biocyc.org/getid?id=EcoCyc:GLUSYNSMALL-MONOMER BioCyc MOB3B:GLUSYNSMALL-MONOMER http://biocyc.org/getid?id=MOB3B:GLUSYNSMALL-MONOMER BioCyc MetaCyc:GLUSYNSMALL-MONOMER http://biocyc.org/getid?id=MetaCyc:GLUSYNSMALL-MONOMER COG COG0493 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0493 DIP DIP-9803N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9803N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1998.1726 http://dx.doi.org/10.1006/jmbi.1998.1726 DOI 10.1016/0378-1119(87)90207-1 http://dx.doi.org/10.1016/0378-1119(87)90207-1 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.4.1.13 http://www.genome.jp/dbget-bin/www_bget?EC:1.4.1.13 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M18747 http://www.ebi.ac.uk/ena/data/view/M18747 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 1.4.1.13 http://enzyme.expasy.org/EC/1.4.1.13 EchoBASE EB0399 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0399 EcoGene EG10404 http://www.ecogene.org/geneInfo.php?eg_id=EG10404 EnsemblBacteria AAC76245 http://www.ensemblgenomes.org/id/AAC76245 EnsemblBacteria AAC76245 http://www.ensemblgenomes.org/id/AAC76245 EnsemblBacteria BAE77257 http://www.ensemblgenomes.org/id/BAE77257 EnsemblBacteria BAE77257 http://www.ensemblgenomes.org/id/BAE77257 EnsemblBacteria BAE77257 http://www.ensemblgenomes.org/id/BAE77257 EnsemblBacteria b3213 http://www.ensemblgenomes.org/id/b3213 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004355 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0006537 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006537 GO_process GO:0008652 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008652 GO_process GO:0097054 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097054 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 GeneID 947723 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947723 HOGENOM HOG000031439 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000031439&db=HOGENOM6 InParanoid P09832 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P09832 IntAct P09832 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P09832* IntEnz 1.4.1.13 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.4.1.13 InterPro IPR006006 http://www.ebi.ac.uk/interpro/entry/IPR006006 InterPro IPR009051 http://www.ebi.ac.uk/interpro/entry/IPR009051 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR017896 http://www.ebi.ac.uk/interpro/entry/IPR017896 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 InterPro IPR028261 http://www.ebi.ac.uk/interpro/entry/IPR028261 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3180 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3180 KEGG_Gene eco:b3213 http://www.genome.jp/dbget-bin/www_bget?eco:b3213 KEGG_Orthology KO:K00266 http://www.genome.jp/dbget-bin/www_bget?KO:K00266 KEGG_Pathway ko00250 http://www.genome.jp/kegg-bin/show_pathway?ko00250 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Reaction rn:R00093 http://www.genome.jp/dbget-bin/www_bget?rn:R00093 KEGG_Reaction rn:R00114 http://www.genome.jp/dbget-bin/www_bget?rn:R00114 KEGG_Reaction rn:R00248 http://www.genome.jp/dbget-bin/www_bget?rn:R00248 MINT MINT-1248739 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1248739 OMA WKPDMSK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WKPDMSK PROSITE PS51379 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51379 PSORT swissprot:GLTD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLTD_ECOLI PSORT-B swissprot:GLTD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLTD_ECOLI PSORT2 swissprot:GLTD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLTD_ECOLI Pfam PF07992 http://pfam.xfam.org/family/PF07992 Pfam PF14691 http://pfam.xfam.org/family/PF14691 Phobius swissprot:GLTD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLTD_ECOLI PhylomeDB P09832 http://phylomedb.org/?seqid=P09832 ProteinModelPortal P09832 http://www.proteinmodelportal.org/query/uniprot/P09832 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2643092 http://www.ncbi.nlm.nih.gov/pubmed/2643092 PubMed 3326786 http://www.ncbi.nlm.nih.gov/pubmed/3326786 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 RefSeq NP_417680 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417680 RefSeq WP_000081674 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000081674 SMR P09832 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P09832 STRING 511145.b3213 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3213&targetmode=cogs STRING COG0493 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0493&targetmode=cogs SUPFAM SSF46548 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46548 SWISS-2DPAGE P09832 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P09832 TIGRFAMs TIGR01318 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01318 UniProtKB GLTD_ECOLI http://www.uniprot.org/uniprot/GLTD_ECOLI UniProtKB-AC P09832 http://www.uniprot.org/uniprot/P09832 charge swissprot:GLTD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLTD_ECOLI eggNOG COG0493 http://eggnogapi.embl.de/nog_data/html/tree/COG0493 eggNOG ENOG4105BZ8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZ8 epestfind swissprot:GLTD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLTD_ECOLI garnier swissprot:GLTD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLTD_ECOLI helixturnhelix swissprot:GLTD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLTD_ECOLI hmoment swissprot:GLTD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLTD_ECOLI iep swissprot:GLTD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLTD_ECOLI inforesidue swissprot:GLTD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLTD_ECOLI octanol swissprot:GLTD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLTD_ECOLI pepcoil swissprot:GLTD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLTD_ECOLI pepdigest swissprot:GLTD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLTD_ECOLI pepinfo swissprot:GLTD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLTD_ECOLI pepnet swissprot:GLTD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLTD_ECOLI pepstats swissprot:GLTD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLTD_ECOLI pepwheel swissprot:GLTD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLTD_ECOLI pepwindow swissprot:GLTD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLTD_ECOLI sigcleave swissprot:GLTD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLTD_ECOLI ## Database ID URL or Descriptions # AltName B6-vitamer kinase {ECO:0000303|PubMed 8764513} # AltName Pyridoxal kinase 1 {ECO:0000303|PubMed 15249053} # BIOPHYSICOCHEMICAL PROPERTIES PDXK_ECOLI Kinetic parameters KM=100 uM for pyridoxal (in the presence of MgATP, at pH 7.3 and 37 degrees Celsius) {ECO 0000269|PubMed 15249053}; KM=50 uM for pyridoxal (in the presence of MgATP, at pH 7.3 and 37 degrees Celsius) {ECO 0000269|PubMed 16740960}; KM=190 uM for pyridoxal (in the presence of ZnATP, at pH 7.3 and 37 degrees Celsius) {ECO 0000269|PubMed 15249053}; KM=25 uM for pyridoxine (in the presence of MgATP, at pH 7.3 and 37 degrees Celsius) {ECO 0000269|PubMed 15249053}; KM=30 uM for pyridoxamine (in the presence of MgATP, at pH 7.3 and 37 degrees Celsius) {ECO 0000269|PubMed 15249053}; KM=10 uM for pyridoxamine (in the presence of ZnATP, at pH 7.3 and 37 degrees Celsius) {ECO 0000269|PubMed 15249053}; KM=600 uM for MgATP (at pH 7.3 and 37 degrees Celsius) {ECO 0000269|PubMed 15249053}; KM=450 uM for MgATP (at pH 7.3 and 37 degrees Celsius) {ECO 0000269|PubMed 16740960}; KM=2100 uM for MgATP (at pH 6.1 and 37 degrees Celsius) {ECO 0000269|PubMed 15249053}; KM=70 uM for ZnATP (in the presence of pyridoxal, at pH 7.3 and 37 degrees Celsius) {ECO 0000269|PubMed 15249053}; KM=45 uM for ZnATP (in the presence of pyridoxamine, at pH 7.3 and 37 degrees Celsius) {ECO 0000269|PubMed 15249053}; Note=kcat is 140 min(-1) for the phosphorylation of PL with MgATP. kcat is 120 min(-1) for the phosphorylation of PL with ZnATP. kcat is 20 min(-1) for the phosphorylation of PN with MgATP. kcat is 40 min(-1) for the phosphorylation of PM with MgATP. kcat is 25 min(-1) for the phosphorylation of PM with ZnATP (at pH 7.3 and 37 degrees Celsius) (PubMed 15249053). kcat is 250 min(-1) for the phosphorylation of PL with MgATP (at pH 7.3 and 37 degrees Celsius) (PubMed 16740960). {ECO 0000269|PubMed 15249053, ECO 0000269|PubMed 16740960}; # BRENDA 2.7.1.35 2026 # BioGrid 4260568 17 # CATALYTIC ACTIVITY ATP + pyridoxamine = ADP + pyridoxamine 5'- phosphate. {ECO:0000269|PubMed 15249053}. # CATALYTIC ACTIVITY PDXK_ECOLI ATP + pyridoxal = ADP + pyridoxal 5'- phosphate. {ECO 0000269|PubMed 15249053, ECO 0000269|PubMed 9537380}. # CATALYTIC ACTIVITY PDXK_ECOLI ATP + pyridoxine = ADP + pyridoxine 5'- phosphate. {ECO 0000269|PubMed 15249053, ECO 0000269|PubMed 9537380}. # CDD cd01173 pyridoxal_pyridoxamine_kinase # COFACTOR PDXK_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 15249053}; Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 15249053}; Note=Can use both zinc and magnesium that is complexed with ATP. However, magnesium seems to be the preferred metal used under physiological conditions. {ECO 0000269|PubMed 15249053}; # DISRUPTION PHENOTYPE PDXK_ECOLI Cells lacking this gene lack pyridoxine kinase activity but still contain pyridoxal kinase activity (PubMed 8764513). Cells lacking this gene and cells lacking both pdxY and pdxK are not auxotrophs, meaning that the de novo pathway of PLP biosynthesis is functional. For PLP salvage, the pdxY single mutant can use both pyridoxine and pyridoxal, the pdxK single mutant can use pyridoxal but not pyridoxine, and the double mutant can no longer use both compounds (PubMed 9537380). {ECO 0000269|PubMed 8764513, ECO 0000269|PubMed 9537380}. # ENZYME REGULATION Is activated by the monovalent cation potassium. {ECO:0000269|PubMed 16740960}. # EcoGene EG12642 pdxK # FUNCTION PDXK_ECOLI B6-vitamer kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxine (PN), pyridoxal (PL), and pyridoxamine (PM), forming their respective 5'-phosphorylated esters, i.e. PNP, PLP and PMP. {ECO 0000269|PubMed 15249053, ECO 0000269|PubMed 9537380}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0005524 ATP binding; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008478 pyridoxal kinase activity; IDA:EcoCyc. # GO_function GO:0008902 hydroxymethylpyrimidine kinase activity; IMP:EcoCyc. # GO_function GO:0046872 metal ion binding; IDA:EcoCyc. # GO_process GO:0008615 pyridoxine biosynthetic process; IMP:EcoCyc. # GO_process GO:0009443 pyridoxal 5'-phosphate salvage; IDA:EcoCyc. # GO_process GO:0016310 phosphorylation; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.1190.20 -; 1. # HAMAP MF_01638 PdxK # IntAct P40191 6 # InterPro IPR004625 PyrdxlKinase # InterPro IPR013749 PM/HMP-P_kinase-1 # InterPro IPR023479 PdxK # InterPro IPR029056 Ribokinase-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00750 Vitamin B6 metabolism # Organism PDXK_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10534 PTHR10534 # PATHWAY Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxal: step 1/1. {ECO 0000269|PubMed:9537380}. # PATHWAY Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxamine 5'-phosphate from pyridoxamine: step 1/1. {ECO 0000305|PubMed:15249053}. # PATHWAY Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxine 5'-phosphate from pyridoxine: step 1/1. {ECO 0000269|PubMed:9537380}. # PATRIC 32120219 VBIEscCol129921_2512 # PDB 2DDM X-ray; 2.10 A; A/B=1-283 # PDB 2DDO X-ray; 2.60 A; A/B=1-283 # PDB 2DDW X-ray; 3.20 A; A/B=1-283 # PIR A65016 A65016 # Pfam PF08543 Phos_pyr_kin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PDXK_ECOLI Pyridoxine/pyridoxal/pyridoxamine kinase {ECO 0000303|PubMed 8764513, ECO 0000303|PubMed 9537380} # RefSeq NP_416913 NC_000913.3 # RefSeq WP_000096674 NZ_LN832404.1 # SIMILARITY Belongs to the pyridoxine kinase family. PdxK subfamily. {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 16740960}. # SUPFAM SSF53613 SSF53613 # TIGRFAMs TIGR00687 pyridox_kin # UniPathway UPA01068 UER00298 # UniPathway UPA01068 UER00299 # UniPathway UPA01068 UER00300 # eggNOG COG2240 LUCA # eggNOG ENOG4107XGF Bacteria BLAST swissprot:PDXK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PDXK_ECOLI BioCyc ECOL316407:JW2411-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2411-MONOMER BioCyc EcoCyc:PDXK-MONOMER http://biocyc.org/getid?id=EcoCyc:PDXK-MONOMER BioCyc MetaCyc:PDXK-MONOMER http://biocyc.org/getid?id=MetaCyc:PDXK-MONOMER COG COG2240 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2240 DOI 10.1016/j.pep.2004.04.021 http://dx.doi.org/10.1016/j.pep.2004.04.021 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1574-6968.1996.tb08368.x http://dx.doi.org/10.1111/j.1574-6968.1996.tb08368.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00122-06 http://dx.doi.org/10.1128/JB.00122-06 EC_number EC:2.7.1.35 {ECO:0000269|PubMed:15249053, ECO:0000269|PubMed:9537380} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.35 {ECO:0000269|PubMed:15249053, ECO:0000269|PubMed:9537380} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J02796 http://www.ebi.ac.uk/ena/data/view/J02796 EMBL M21994 http://www.ebi.ac.uk/ena/data/view/M21994 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U53700 http://www.ebi.ac.uk/ena/data/view/U53700 ENZYME 2.7.1.35 {ECO:0000269|PubMed:15249053, ECO:0000269|PubMed:9537380} http://enzyme.expasy.org/EC/2.7.1.35 {ECO:0000269|PubMed:15249053, ECO:0000269|PubMed:9537380} EchoBASE EB2519 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2519 EcoGene EG12642 http://www.ecogene.org/geneInfo.php?eg_id=EG12642 EnsemblBacteria AAC75471 http://www.ensemblgenomes.org/id/AAC75471 EnsemblBacteria AAC75471 http://www.ensemblgenomes.org/id/AAC75471 EnsemblBacteria BAA16292 http://www.ensemblgenomes.org/id/BAA16292 EnsemblBacteria BAA16292 http://www.ensemblgenomes.org/id/BAA16292 EnsemblBacteria BAA16292 http://www.ensemblgenomes.org/id/BAA16292 EnsemblBacteria b2418 http://www.ensemblgenomes.org/id/b2418 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0008478 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008478 GO_function GO:0008902 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008902 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0008615 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008615 GO_process GO:0009443 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009443 GO_process GO:0016310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016310 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.1190.20 http://www.cathdb.info/version/latest/superfamily/3.40.1190.20 GeneID 946881 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946881 HAMAP MF_01638 http://hamap.expasy.org/unirule/MF_01638 HOGENOM HOG000258173 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000258173&db=HOGENOM6 InParanoid P40191 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P40191 IntAct P40191 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P40191* IntEnz 2.7.1.35 {ECO:0000269|PubMed:15249053, ECO:0000269|PubMed:9537380} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.35 {ECO:0000269|PubMed:15249053, ECO:0000269|PubMed:9537380} InterPro IPR004625 http://www.ebi.ac.uk/interpro/entry/IPR004625 InterPro IPR013749 http://www.ebi.ac.uk/interpro/entry/IPR013749 InterPro IPR023479 http://www.ebi.ac.uk/interpro/entry/IPR023479 InterPro IPR029056 http://www.ebi.ac.uk/interpro/entry/IPR029056 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2411 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2411 KEGG_Gene eco:b2418 http://www.genome.jp/dbget-bin/www_bget?eco:b2418 KEGG_Orthology KO:K00868 http://www.genome.jp/dbget-bin/www_bget?KO:K00868 KEGG_Pathway ko00750 http://www.genome.jp/kegg-bin/show_pathway?ko00750 KEGG_Reaction rn:R00174 http://www.genome.jp/dbget-bin/www_bget?rn:R00174 KEGG_Reaction rn:R01909 http://www.genome.jp/dbget-bin/www_bget?rn:R01909 KEGG_Reaction rn:R02493 http://www.genome.jp/dbget-bin/www_bget?rn:R02493 OMA WVAITSA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WVAITSA PANTHER PTHR10534 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10534 PDB 2DDM http://www.ebi.ac.uk/pdbe-srv/view/entry/2DDM PDB 2DDO http://www.ebi.ac.uk/pdbe-srv/view/entry/2DDO PDB 2DDW http://www.ebi.ac.uk/pdbe-srv/view/entry/2DDW PDBsum 2DDM http://www.ebi.ac.uk/pdbsum/2DDM PDBsum 2DDO http://www.ebi.ac.uk/pdbsum/2DDO PDBsum 2DDW http://www.ebi.ac.uk/pdbsum/2DDW PSORT swissprot:PDXK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PDXK_ECOLI PSORT-B swissprot:PDXK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PDXK_ECOLI PSORT2 swissprot:PDXK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PDXK_ECOLI Pfam PF08543 http://pfam.xfam.org/family/PF08543 Phobius swissprot:PDXK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PDXK_ECOLI PhylomeDB P40191 http://phylomedb.org/?seqid=P40191 ProteinModelPortal P40191 http://www.proteinmodelportal.org/query/uniprot/P40191 PubMed 15249053 http://www.ncbi.nlm.nih.gov/pubmed/15249053 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16740960 http://www.ncbi.nlm.nih.gov/pubmed/16740960 PubMed 2457575 http://www.ncbi.nlm.nih.gov/pubmed/2457575 PubMed 2960675 http://www.ncbi.nlm.nih.gov/pubmed/2960675 PubMed 8764513 http://www.ncbi.nlm.nih.gov/pubmed/8764513 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9537380 http://www.ncbi.nlm.nih.gov/pubmed/9537380 RefSeq NP_416913 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416913 RefSeq WP_000096674 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000096674 SMR P40191 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P40191 STRING 511145.b2418 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2418&targetmode=cogs STRING COG2240 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2240&targetmode=cogs SUPFAM SSF53613 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53613 TIGRFAMs TIGR00687 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00687 UniProtKB PDXK_ECOLI http://www.uniprot.org/uniprot/PDXK_ECOLI UniProtKB-AC P40191 http://www.uniprot.org/uniprot/P40191 charge swissprot:PDXK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PDXK_ECOLI eggNOG COG2240 http://eggnogapi.embl.de/nog_data/html/tree/COG2240 eggNOG ENOG4107XGF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107XGF epestfind swissprot:PDXK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PDXK_ECOLI garnier swissprot:PDXK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PDXK_ECOLI helixturnhelix swissprot:PDXK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PDXK_ECOLI hmoment swissprot:PDXK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PDXK_ECOLI iep swissprot:PDXK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PDXK_ECOLI inforesidue swissprot:PDXK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PDXK_ECOLI octanol swissprot:PDXK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PDXK_ECOLI pepcoil swissprot:PDXK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PDXK_ECOLI pepdigest swissprot:PDXK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PDXK_ECOLI pepinfo swissprot:PDXK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PDXK_ECOLI pepnet swissprot:PDXK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PDXK_ECOLI pepstats swissprot:PDXK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PDXK_ECOLI pepwheel swissprot:PDXK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PDXK_ECOLI pepwindow swissprot:PDXK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PDXK_ECOLI sigcleave swissprot:PDXK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PDXK_ECOLI ## Database ID URL or Descriptions # BioGrid 4261568 6 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG14252 ymfN # Gene3D 1.10.10.10 -; 1. # InterPro IPR005021 Phage_terminase # InterPro IPR011991 WHTH_DNA-bd_dom # Organism YMFN_ECOLI Escherichia coli (strain K12) # PATRIC 48661559 VBIEscCol107702_1148 # PIR B64860 B64860 # Pfam PF03354 Terminase_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YMFN_ECOLI Uncharacterized protein YmfN # RefSeq WP_000104929 NZ_CP010440.1 # SIMILARITY Belongs to the phage terminase family. {ECO 0000305}. # SUPFAM SSF46785 SSF46785 # eggNOG COG4626 LUCA # eggNOG ENOG4105CAR Bacteria BLAST swissprot:YMFN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YMFN_ECOLI BioCyc ECOL316407:JW1135-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1135-MONOMER BioCyc EcoCyc:G6593-MONOMER http://biocyc.org/getid?id=EcoCyc:G6593-MONOMER DIP DIP-12724N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12724N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4000 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4000 EcoGene EG14252 http://www.ecogene.org/geneInfo.php?eg_id=EG14252 EnsemblBacteria BAA35975 http://www.ensemblgenomes.org/id/BAA35975 EnsemblBacteria BAA35975 http://www.ensemblgenomes.org/id/BAA35975 EnsemblBacteria BAA35975 http://www.ensemblgenomes.org/id/BAA35975 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 HOGENOM HOG000202510 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000202510&db=HOGENOM6 InParanoid P75978 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75978 IntAct P75978 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75978* InterPro IPR005021 http://www.ebi.ac.uk/interpro/entry/IPR005021 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW1135 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1135 MINT MINT-1257432 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1257432 OMA IDEYHEH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IDEYHEH PSORT swissprot:YMFN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YMFN_ECOLI PSORT-B swissprot:YMFN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YMFN_ECOLI PSORT2 swissprot:YMFN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YMFN_ECOLI Pfam PF03354 http://pfam.xfam.org/family/PF03354 Phobius swissprot:YMFN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YMFN_ECOLI PhylomeDB P75978 http://phylomedb.org/?seqid=P75978 ProteinModelPortal P75978 http://www.proteinmodelportal.org/query/uniprot/P75978 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000104929 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000104929 SMR P75978 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75978 STRING 316407.4062724 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.4062724&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB YMFN_ECOLI http://www.uniprot.org/uniprot/YMFN_ECOLI UniProtKB-AC P75978 http://www.uniprot.org/uniprot/P75978 charge swissprot:YMFN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YMFN_ECOLI eggNOG COG4626 http://eggnogapi.embl.de/nog_data/html/tree/COG4626 eggNOG ENOG4105CAR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CAR epestfind swissprot:YMFN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YMFN_ECOLI garnier swissprot:YMFN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YMFN_ECOLI helixturnhelix swissprot:YMFN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YMFN_ECOLI hmoment swissprot:YMFN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YMFN_ECOLI iep swissprot:YMFN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YMFN_ECOLI inforesidue swissprot:YMFN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YMFN_ECOLI octanol swissprot:YMFN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YMFN_ECOLI pepcoil swissprot:YMFN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YMFN_ECOLI pepdigest swissprot:YMFN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YMFN_ECOLI pepinfo swissprot:YMFN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YMFN_ECOLI pepnet swissprot:YMFN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YMFN_ECOLI pepstats swissprot:YMFN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YMFN_ECOLI pepwheel swissprot:YMFN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YMFN_ECOLI pepwindow swissprot:YMFN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YMFN_ECOLI sigcleave swissprot:YMFN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YMFN_ECOLI ## Database ID URL or Descriptions # BioGrid 4260353 6 # EcoGene EG12678 znuA # FUNCTION ZNUA_ECOLI Involved in the high-affinity zinc uptake transport system. # GO_component GO:0005886 plasma membrane; IBA:GO_Central. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006829 zinc II ion transport; IEA:UniProtKB-KW. # GO_process GO:0007155 cell adhesion; IEA:InterPro. # GO_process GO:0010043 response to zinc ion; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # GOslim_process GO:0007155 cell adhesion # GOslim_process GO:0008150 biological_process # INDUCTION Maximally induced 30 minutes under zinc-limiting conditions, still induced in stationary phase. {ECO:0000269|PubMed 22196016}. # InterPro IPR006127 ZnuA-like # InterPro IPR006128 Lipoprotein_4 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00242 Zinc transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism ZNUA_ECOLI Escherichia coli (strain K12) # PATRIC 32119037 VBIEscCol129921_1936 # PDB 2OGW X-ray; 1.83 A; A/B=1-310 # PDB 2OSV X-ray; 1.75 A; A/B=27-310 # PDB 2PRS X-ray; 1.70 A; A/B=27-310 # PDB 2PS0 X-ray; 2.00 A; A/B=27-310 # PDB 2PS3 X-ray; 2.47 A; A/B=27-310 # PDB 2PS9 X-ray; 2.15 A; A/B=27-310 # PIR A64948 A64948 # PRINTS PR00690 ADHESNFAMILY # Pfam PF01297 ZnuA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ZNUA_ECOLI High-affinity zinc uptake system protein ZnuA # RefSeq NP_416371 NC_000913.3 # RefSeq WP_001300644 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA81030.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the bacterial solute-binding protein 9 family. {ECO 0000305}. # SUBCELLULAR LOCATION ZNUA_ECOLI Periplasm. # TCDB 3.A.1.15 the atp-binding cassette (abc) superfamily # eggNOG COG4531 LUCA # eggNOG ENOG4105NXV Bacteria BLAST swissprot:ZNUA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ZNUA_ECOLI BioCyc ECOL316407:JW5831-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5831-MONOMER BioCyc EcoCyc:ZNUA-MONOMER http://biocyc.org/getid?id=EcoCyc:ZNUA-MONOMER BioCyc MetaCyc:ZNUA-MONOMER http://biocyc.org/getid?id=MetaCyc:ZNUA-MONOMER COG COG0803 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0803 DIP DIP-12949N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12949N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1998.1726 http://dx.doi.org/10.1006/jmbi.1998.1726 DOI 10.1016/j.jinorgbio.2011.11.022 http://dx.doi.org/10.1016/j.jinorgbio.2011.11.022 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1998.00883.x http://dx.doi.org/10.1046/j.1365-2958.1998.00883.x DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U38702 http://www.ebi.ac.uk/ena/data/view/U38702 EchoBASE EB2543 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2543 EcoGene EG12678 http://www.ecogene.org/geneInfo.php?eg_id=EG12678 EnsemblBacteria AAC74927 http://www.ensemblgenomes.org/id/AAC74927 EnsemblBacteria AAC74927 http://www.ensemblgenomes.org/id/AAC74927 EnsemblBacteria BAA15665 http://www.ensemblgenomes.org/id/BAA15665 EnsemblBacteria BAA15665 http://www.ensemblgenomes.org/id/BAA15665 EnsemblBacteria BAA15665 http://www.ensemblgenomes.org/id/BAA15665 EnsemblBacteria b1857 http://www.ensemblgenomes.org/id/b1857 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006829 GO_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GO_process GO:0010043 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010043 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 946375 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946375 HOGENOM HOG000180311 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000180311&db=HOGENOM6 InParanoid P39172 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39172 InterPro IPR006127 http://www.ebi.ac.uk/interpro/entry/IPR006127 InterPro IPR006128 http://www.ebi.ac.uk/interpro/entry/IPR006128 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5831 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5831 KEGG_Gene eco:b1857 http://www.genome.jp/dbget-bin/www_bget?eco:b1857 KEGG_Orthology KO:K09815 http://www.genome.jp/dbget-bin/www_bget?KO:K09815 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA RHFGEDS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RHFGEDS PDB 2OGW http://www.ebi.ac.uk/pdbe-srv/view/entry/2OGW PDB 2OSV http://www.ebi.ac.uk/pdbe-srv/view/entry/2OSV PDB 2PRS http://www.ebi.ac.uk/pdbe-srv/view/entry/2PRS PDB 2PS0 http://www.ebi.ac.uk/pdbe-srv/view/entry/2PS0 PDB 2PS3 http://www.ebi.ac.uk/pdbe-srv/view/entry/2PS3 PDB 2PS9 http://www.ebi.ac.uk/pdbe-srv/view/entry/2PS9 PDBsum 2OGW http://www.ebi.ac.uk/pdbsum/2OGW PDBsum 2OSV http://www.ebi.ac.uk/pdbsum/2OSV PDBsum 2PRS http://www.ebi.ac.uk/pdbsum/2PRS PDBsum 2PS0 http://www.ebi.ac.uk/pdbsum/2PS0 PDBsum 2PS3 http://www.ebi.ac.uk/pdbsum/2PS3 PDBsum 2PS9 http://www.ebi.ac.uk/pdbsum/2PS9 PRINTS PR00690 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00690 PSORT swissprot:ZNUA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ZNUA_ECOLI PSORT-B swissprot:ZNUA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ZNUA_ECOLI PSORT2 swissprot:ZNUA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ZNUA_ECOLI Pfam PF01297 http://pfam.xfam.org/family/PF01297 Phobius swissprot:ZNUA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ZNUA_ECOLI PhylomeDB P39172 http://phylomedb.org/?seqid=P39172 ProteinModelPortal P39172 http://www.proteinmodelportal.org/query/uniprot/P39172 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22196016 http://www.ncbi.nlm.nih.gov/pubmed/22196016 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 PubMed 9680209 http://www.ncbi.nlm.nih.gov/pubmed/9680209 RefSeq NP_416371 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416371 RefSeq WP_001300644 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300644 SMR P39172 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39172 STRING 511145.b1857 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1857&targetmode=cogs STRING COG0803 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0803&targetmode=cogs SWISS-2DPAGE P39172 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P39172 TCDB 3.A.1.15 http://www.tcdb.org/search/result.php?tc=3.A.1.15 UniProtKB ZNUA_ECOLI http://www.uniprot.org/uniprot/ZNUA_ECOLI UniProtKB-AC P39172 http://www.uniprot.org/uniprot/P39172 charge swissprot:ZNUA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ZNUA_ECOLI eggNOG COG4531 http://eggnogapi.embl.de/nog_data/html/tree/COG4531 eggNOG ENOG4105NXV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105NXV epestfind swissprot:ZNUA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ZNUA_ECOLI garnier swissprot:ZNUA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ZNUA_ECOLI helixturnhelix swissprot:ZNUA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ZNUA_ECOLI hmoment swissprot:ZNUA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ZNUA_ECOLI iep swissprot:ZNUA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ZNUA_ECOLI inforesidue swissprot:ZNUA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ZNUA_ECOLI octanol swissprot:ZNUA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ZNUA_ECOLI pepcoil swissprot:ZNUA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ZNUA_ECOLI pepdigest swissprot:ZNUA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ZNUA_ECOLI pepinfo swissprot:ZNUA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ZNUA_ECOLI pepnet swissprot:ZNUA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ZNUA_ECOLI pepstats swissprot:ZNUA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ZNUA_ECOLI pepwheel swissprot:ZNUA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ZNUA_ECOLI pepwindow swissprot:ZNUA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ZNUA_ECOLI sigcleave swissprot:ZNUA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ZNUA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261453 6 # COFACTOR YIDJ_ECOLI Name=Ca(2+); Xref=ChEBI CHEBI 29108; Evidence={ECO 0000250}; Note=Binds 1 Ca(2+) ion per subunit. {ECO 0000250}; # EcoGene EG11705 yidJ # GO_function GO:0008484 sulfuric ester hydrolase activity; IEA:InterPro. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0008152 metabolic process; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # Gene3D 3.40.720.10 -; 1. # InterPro IPR000917 Sulfatase_N # InterPro IPR017849 Alkaline_Pase-like_a/b/a # InterPro IPR017850 Alkaline_phosphatase_core # InterPro IPR024607 Sulfatase_CS # InterPro IPR032506 DUF4976 # KEGG_Brite ko01000 Enzymes # Organism YIDJ_ECOLI Escherichia coli (strain K12) # PATRIC 32122847 VBIEscCol129921_3799 # PIR G65169 G65169 # PROSITE PS00149 SULFATASE_2 # PROSITE PS00523 SULFATASE_1 # PTM YIDJ_ECOLI The conversion to 3-oxoalanine (also known as C- formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. {ECO 0000250}. # Pfam PF00884 Sulfatase # Pfam PF16347 DUF4976 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIDJ_ECOLI Uncharacterized sulfatase YidJ # RefSeq NP_418134 NC_000913.3 # RefSeq WP_000828527 NZ_LN832404.1 # SIMILARITY Belongs to the sulfatase family. {ECO 0000305}. # SUPFAM SSF53649 SSF53649 # eggNOG COG3119 LUCA # eggNOG ENOG4105CBG Bacteria BLAST swissprot:YIDJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIDJ_ECOLI BioCyc ECOL316407:JW3654-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3654-MONOMER BioCyc EcoCyc:EG11705-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11705-MONOMER COG COG3119 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3119 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.6.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.6.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.6.- http://enzyme.expasy.org/EC/3.1.6.- EchoBASE EB1656 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1656 EcoGene EG11705 http://www.ecogene.org/geneInfo.php?eg_id=EG11705 EnsemblBacteria AAC76701 http://www.ensemblgenomes.org/id/AAC76701 EnsemblBacteria AAC76701 http://www.ensemblgenomes.org/id/AAC76701 EnsemblBacteria BAE77615 http://www.ensemblgenomes.org/id/BAE77615 EnsemblBacteria BAE77615 http://www.ensemblgenomes.org/id/BAE77615 EnsemblBacteria BAE77615 http://www.ensemblgenomes.org/id/BAE77615 EnsemblBacteria b3678 http://www.ensemblgenomes.org/id/b3678 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008484 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008484 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0008152 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008152 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.720.10 http://www.cathdb.info/version/latest/superfamily/3.40.720.10 GeneID 948188 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948188 HOGENOM HOG000126316 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126316&db=HOGENOM6 InParanoid P31447 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31447 IntEnz 3.1.6 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.6 InterPro IPR000917 http://www.ebi.ac.uk/interpro/entry/IPR000917 InterPro IPR017849 http://www.ebi.ac.uk/interpro/entry/IPR017849 InterPro IPR017850 http://www.ebi.ac.uk/interpro/entry/IPR017850 InterPro IPR024607 http://www.ebi.ac.uk/interpro/entry/IPR024607 InterPro IPR032506 http://www.ebi.ac.uk/interpro/entry/IPR032506 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3654 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3654 KEGG_Gene eco:b3678 http://www.genome.jp/dbget-bin/www_bget?eco:b3678 KEGG_Orthology KO:K01138 http://www.genome.jp/dbget-bin/www_bget?KO:K01138 OMA GAHRLIS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GAHRLIS PROSITE PS00149 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00149 PROSITE PS00523 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00523 PSORT swissprot:YIDJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIDJ_ECOLI PSORT-B swissprot:YIDJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIDJ_ECOLI PSORT2 swissprot:YIDJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIDJ_ECOLI Pfam PF00884 http://pfam.xfam.org/family/PF00884 Pfam PF16347 http://pfam.xfam.org/family/PF16347 Phobius swissprot:YIDJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIDJ_ECOLI PhylomeDB P31447 http://phylomedb.org/?seqid=P31447 ProteinModelPortal P31447 http://www.proteinmodelportal.org/query/uniprot/P31447 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418134 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418134 RefSeq WP_000828527 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000828527 STRING 511145.b3678 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3678&targetmode=cogs STRING COG3119 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3119&targetmode=cogs SUPFAM SSF53649 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53649 UniProtKB YIDJ_ECOLI http://www.uniprot.org/uniprot/YIDJ_ECOLI UniProtKB-AC P31447 http://www.uniprot.org/uniprot/P31447 charge swissprot:YIDJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIDJ_ECOLI eggNOG COG3119 http://eggnogapi.embl.de/nog_data/html/tree/COG3119 eggNOG ENOG4105CBG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CBG epestfind swissprot:YIDJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIDJ_ECOLI garnier swissprot:YIDJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIDJ_ECOLI helixturnhelix swissprot:YIDJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIDJ_ECOLI hmoment swissprot:YIDJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIDJ_ECOLI iep swissprot:YIDJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIDJ_ECOLI inforesidue swissprot:YIDJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIDJ_ECOLI octanol swissprot:YIDJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIDJ_ECOLI pepcoil swissprot:YIDJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIDJ_ECOLI pepdigest swissprot:YIDJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIDJ_ECOLI pepinfo swissprot:YIDJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIDJ_ECOLI pepnet swissprot:YIDJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIDJ_ECOLI pepstats swissprot:YIDJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIDJ_ECOLI pepwheel swissprot:YIDJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIDJ_ECOLI pepwindow swissprot:YIDJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIDJ_ECOLI sigcleave swissprot:YIDJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIDJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4261048 7 # EcoGene EG12636 dsrB # HAMAP MF_01549 DsrB # INDUCTION DSRB_ECOLI Expression is dependent on RpoS. # IntAct P0AEG8 2 # InterPro IPR019717 Dextransucrase_DSRB # Organism DSRB_ECOLI Escherichia coli (strain K12) # PATRIC 32119233 VBIEscCol129921_2031 # PIR I59352 I59352 # Pfam PF10781 DSRB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DSRB_ECOLI Protein DsrB # RefSeq NP_416462 NC_000913.3 # RefSeq WP_000867217 NZ_LN832404.1 # SIMILARITY Belongs to the DsrB family. {ECO 0000305}. # eggNOG ENOG4105VZF Bacteria # eggNOG ENOG41124RJ LUCA BLAST swissprot:DSRB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DSRB_ECOLI BioCyc ECOL316407:JW1936-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1936-MONOMER BioCyc EcoCyc:G7045-MONOMER http://biocyc.org/getid?id=EcoCyc:G7045-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.92.6.2003 http://dx.doi.org/10.1073/pnas.92.6.2003 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U17136 http://www.ebi.ac.uk/ena/data/view/U17136 EchoBASE EB2517 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2517 EcoGene EG12636 http://www.ecogene.org/geneInfo.php?eg_id=EG12636 EnsemblBacteria AAC75019 http://www.ensemblgenomes.org/id/AAC75019 EnsemblBacteria AAC75019 http://www.ensemblgenomes.org/id/AAC75019 EnsemblBacteria BAA15777 http://www.ensemblgenomes.org/id/BAA15777 EnsemblBacteria BAA15777 http://www.ensemblgenomes.org/id/BAA15777 EnsemblBacteria BAA15777 http://www.ensemblgenomes.org/id/BAA15777 EnsemblBacteria b1952 http://www.ensemblgenomes.org/id/b1952 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946468 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946468 HAMAP MF_01549 http://hamap.expasy.org/unirule/MF_01549 HOGENOM HOG000290465 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000290465&db=HOGENOM6 IntAct P0AEG8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEG8* InterPro IPR019717 http://www.ebi.ac.uk/interpro/entry/IPR019717 KEGG_Gene ecj:JW1936 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1936 KEGG_Gene eco:b1952 http://www.genome.jp/dbget-bin/www_bget?eco:b1952 OMA IWFFNEL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IWFFNEL PSORT swissprot:DSRB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DSRB_ECOLI PSORT-B swissprot:DSRB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DSRB_ECOLI PSORT2 swissprot:DSRB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DSRB_ECOLI Pfam PF10781 http://pfam.xfam.org/family/PF10781 Phobius swissprot:DSRB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DSRB_ECOLI ProteinModelPortal P0AEG8 http://www.proteinmodelportal.org/query/uniprot/P0AEG8 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7534408 http://www.ncbi.nlm.nih.gov/pubmed/7534408 PubMed 8670904 http://www.ncbi.nlm.nih.gov/pubmed/8670904 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416462 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416462 RefSeq WP_000867217 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000867217 SMR P0AEG8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEG8 STRING 511145.b1952 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1952&targetmode=cogs UniProtKB DSRB_ECOLI http://www.uniprot.org/uniprot/DSRB_ECOLI UniProtKB-AC P0AEG8 http://www.uniprot.org/uniprot/P0AEG8 charge swissprot:DSRB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DSRB_ECOLI eggNOG ENOG4105VZF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VZF eggNOG ENOG41124RJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG41124RJ epestfind swissprot:DSRB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DSRB_ECOLI garnier swissprot:DSRB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DSRB_ECOLI helixturnhelix swissprot:DSRB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DSRB_ECOLI hmoment swissprot:DSRB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DSRB_ECOLI iep swissprot:DSRB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DSRB_ECOLI inforesidue swissprot:DSRB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DSRB_ECOLI octanol swissprot:DSRB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DSRB_ECOLI pepcoil swissprot:DSRB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DSRB_ECOLI pepdigest swissprot:DSRB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DSRB_ECOLI pepinfo swissprot:DSRB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DSRB_ECOLI pepnet swissprot:DSRB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DSRB_ECOLI pepstats swissprot:DSRB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DSRB_ECOLI pepwheel swissprot:DSRB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DSRB_ECOLI pepwindow swissprot:DSRB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DSRB_ECOLI sigcleave swissprot:DSRB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DSRB_ECOLI ## Database ID URL or Descriptions # AltName CHEZ_ECOLI Chemotaxis protein CheZ # BioGrid 4259554 391 # EcoGene EG10151 cheZ # FUNCTION CHEZ_ECOLI Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P). {ECO 0000269|PubMed 10852888, ECO 0000269|PubMed 8820640}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0009288 bacterial-type flagellum; IEA:InterPro. # GO_function GO:0004721 phosphoprotein phosphatase activity; IDA:EcoCyc. # GO_process GO:0006935 chemotaxis; IEA:UniProtKB-KW. # GO_process GO:0050920 regulation of chemotaxis; IEA:InterPro. # GO_process GO:0071977 bacterial-type flagellum-dependent swimming motility; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043226 organelle # GOslim_function GO:0016791 phosphatase activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0040011 locomotion # GOslim_process GO:0048870 cell motility # INTERACTION CHEZ_ECOLI P07363 cheA; NbExp=3; IntAct=EBI-546726, EBI-1026773; P0AE67 cheY; NbExp=3; IntAct=EBI-546726, EBI-546693; # IntAct P0A9H9 22 # InterPro IPR007439 Chemotax_Pase_CheZ # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Pathway ko02030 Bacterial chemotaxis # Organism CHEZ_ECOLI Escherichia coli (strain K12) # PATRIC 32119089 VBIEscCol129921_1962 # PDB 1KMI X-ray; 2.90 A; Z=1-214 # PIR F25195 QRECCZ # PIRSF PIRSF002884 CheZ # Pfam PF04344 CheZ # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CHEZ_ECOLI Protein phosphatase CheZ # RefSeq NP_416395 NC_000913.3 # RefSeq WP_000983609 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA23571.1; Type=Miscellaneous discrepancy; Evidence={ECO 0000305}; # SIMILARITY Belongs to the CheZ family. {ECO 0000305}. # SUBCELLULAR LOCATION CHEZ_ECOLI Cytoplasm {ECO 0000269|PubMed 12644507}. Note=Colocalizes with CheA chemoreceptor patches near the cell poles, which requires CheA(short). # SUBUNIT CHEZ_ECOLI Homodimer. Interacts with CheA isoform CheA(short). Interacts (via C-terminus) with phosphorylated CheY (CheY-P). {ECO 0000269|PubMed 10852888, ECO 0000269|PubMed 12080332, ECO 0000269|PubMed 17998207, ECO 0000269|PubMed 8820640}. # eggNOG COG3143 LUCA # eggNOG ENOG4108KCC Bacteria BLAST swissprot:CHEZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CHEZ_ECOLI BioCyc ECOL316407:JW1870-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1870-MONOMER BioCyc EcoCyc:CHEZ-MONOMER http://biocyc.org/getid?id=EcoCyc:CHEZ-MONOMER COG COG3143 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3143 DIP DIP-9275N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9275N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb816 http://dx.doi.org/10.1038/nsb816 DOI 10.1046/j.1365-2958.1996.393934.x http://dx.doi.org/10.1046/j.1365-2958.1996.393934.x DOI 10.1074/jbc.M704400200 http://dx.doi.org/10.1074/jbc.M704400200 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.12.3544-3552.2000 http://dx.doi.org/10.1128/JB.182.12.3544-3552.2000 DOI 10.1128/JB.185.7.2354-2361.2003 http://dx.doi.org/10.1128/JB.185.7.2354-2361.2003 EC_number EC:3.1.3.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K02175 http://www.ebi.ac.uk/ena/data/view/K02175 EMBL M13463 http://www.ebi.ac.uk/ena/data/view/M13463 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.3.- http://enzyme.expasy.org/EC/3.1.3.- EchoBASE EB0149 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0149 EcoGene EG10151 http://www.ecogene.org/geneInfo.php?eg_id=EG10151 EnsemblBacteria AAC74951 http://www.ensemblgenomes.org/id/AAC74951 EnsemblBacteria AAC74951 http://www.ensemblgenomes.org/id/AAC74951 EnsemblBacteria BAA15697 http://www.ensemblgenomes.org/id/BAA15697 EnsemblBacteria BAA15697 http://www.ensemblgenomes.org/id/BAA15697 EnsemblBacteria BAA15697 http://www.ensemblgenomes.org/id/BAA15697 EnsemblBacteria b1881 http://www.ensemblgenomes.org/id/b1881 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0009288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009288 GO_function GO:0004721 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004721 GO_process GO:0006935 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006935 GO_process GO:0050920 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050920 GO_process GO:0071977 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071977 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0040011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 GeneID 946392 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946392 HOGENOM HOG000254724 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000254724&db=HOGENOM6 InParanoid P0A9H9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9H9 IntAct P0A9H9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9H9* IntEnz 3.1.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3 InterPro IPR007439 http://www.ebi.ac.uk/interpro/entry/IPR007439 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW1870 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1870 KEGG_Gene eco:b1881 http://www.genome.jp/dbget-bin/www_bget?eco:b1881 KEGG_Orthology KO:K03414 http://www.genome.jp/dbget-bin/www_bget?KO:K03414 KEGG_Pathway ko02030 http://www.genome.jp/kegg-bin/show_pathway?ko02030 MINT MINT-1264225 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1264225 OMA GPQIHAD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GPQIHAD PDB 1KMI http://www.ebi.ac.uk/pdbe-srv/view/entry/1KMI PDBsum 1KMI http://www.ebi.ac.uk/pdbsum/1KMI PSORT swissprot:CHEZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CHEZ_ECOLI PSORT-B swissprot:CHEZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CHEZ_ECOLI PSORT2 swissprot:CHEZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CHEZ_ECOLI Pfam PF04344 http://pfam.xfam.org/family/PF04344 Phobius swissprot:CHEZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CHEZ_ECOLI PhylomeDB P0A9H9 http://phylomedb.org/?seqid=P0A9H9 ProteinModelPortal P0A9H9 http://www.proteinmodelportal.org/query/uniprot/P0A9H9 PubMed 10852888 http://www.ncbi.nlm.nih.gov/pubmed/10852888 PubMed 12080332 http://www.ncbi.nlm.nih.gov/pubmed/12080332 PubMed 12644507 http://www.ncbi.nlm.nih.gov/pubmed/12644507 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17998207 http://www.ncbi.nlm.nih.gov/pubmed/17998207 PubMed 3510184 http://www.ncbi.nlm.nih.gov/pubmed/3510184 PubMed 6090423 http://www.ncbi.nlm.nih.gov/pubmed/6090423 PubMed 8820640 http://www.ncbi.nlm.nih.gov/pubmed/8820640 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_416395 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416395 RefSeq WP_000983609 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000983609 SMR P0A9H9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9H9 STRING 511145.b1881 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1881&targetmode=cogs STRING COG3143 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3143&targetmode=cogs SWISS-2DPAGE P0A9H9 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A9H9 UniProtKB CHEZ_ECOLI http://www.uniprot.org/uniprot/CHEZ_ECOLI UniProtKB-AC P0A9H9 http://www.uniprot.org/uniprot/P0A9H9 charge swissprot:CHEZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CHEZ_ECOLI eggNOG COG3143 http://eggnogapi.embl.de/nog_data/html/tree/COG3143 eggNOG ENOG4108KCC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108KCC epestfind swissprot:CHEZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CHEZ_ECOLI garnier swissprot:CHEZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CHEZ_ECOLI helixturnhelix swissprot:CHEZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CHEZ_ECOLI hmoment swissprot:CHEZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CHEZ_ECOLI iep swissprot:CHEZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CHEZ_ECOLI inforesidue swissprot:CHEZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CHEZ_ECOLI octanol swissprot:CHEZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CHEZ_ECOLI pepcoil swissprot:CHEZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CHEZ_ECOLI pepdigest swissprot:CHEZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CHEZ_ECOLI pepinfo swissprot:CHEZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CHEZ_ECOLI pepnet swissprot:CHEZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CHEZ_ECOLI pepstats swissprot:CHEZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CHEZ_ECOLI pepwheel swissprot:CHEZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CHEZ_ECOLI pepwindow swissprot:CHEZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CHEZ_ECOLI sigcleave swissprot:CHEZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CHEZ_ECOLI ## Database ID URL or Descriptions # AltName ATP-dependent protease La {ECO:0000255|HAMAP-Rule MF_01973} # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=0.201 mM for ATP for ATPase activity {ECO 0000269|PubMed:15560777}; # BRENDA 3.4.21.53 2026 # BioGrid 4260734 24 # CATALYTIC ACTIVITY Hydrolysis of proteins in presence of ATP. {ECO:0000255|HAMAP-Rule MF_01973}. # DISRUPTION PHENOTYPE LON_ECOLI When both lon and ycgE are disrupted levels of OmpF decrease, leading to lower drug susceptibility, with a greater effect at 26 degrees than at 37 degrees Celsius. The mechanism is not yet understood (PubMed 19721064). Decreased persister cell formation upon antibiotic challenge due probably due to increased levels of MazF toxin (PubMed 24375411). {ECO 0000269|PubMed 19721064, ECO 0000269|PubMed 24375411}. # ENZYME REGULATION LON_ECOLI Contains an allosteric site (distinct from its active site), whose occupancy by an unfolded polypeptide leads to enzyme activation. # EcoGene EG10542 lon # FUNCTION LON_ECOLI ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins, including some antitoxins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. Endogenous substrates include the regulatory proteins RcsA and SulA, the transcriptional activator SoxS, UmuD and antitoxins CcdA, HipB and MazE (PubMed 8022284, PubMed 16460757, PubMed 22720069, PubMed 24375411). Its overproduction specifically inhibits translation through at least two different pathways, one of them being the YoeB-YefM toxin-antitoxin system (PubMed 15009896). {ECO 0000269|PubMed 12135363, ECO 0000269|PubMed 15009896, ECO 0000269|PubMed 16460757, ECO 0000269|PubMed 16584195, ECO 0000269|PubMed 19721064, ECO 0000269|PubMed 22720069, ECO 0000269|PubMed 24375411, ECO 0000269|PubMed 8022284}. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IDA:EcoliWiki. # GO_function GO:0004176 ATP-dependent peptidase activity; IDA:EcoliWiki. # GO_function GO:0004252 serine-type endopeptidase activity; IMP:EcoliWiki. # GO_function GO:0005524 ATP binding; IDA:EcoCyc. # GO_function GO:0008233 peptidase activity; IDA:EcoliWiki. # GO_function GO:0016887 ATPase activity; IDA:EcoliWiki. # GO_function GO:0043565 sequence-specific DNA binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006508 proteolysis; IDA:EcoliWiki. # GO_process GO:0006515 misfolded or incompletely synthesized protein catabolic process; IMP:EcoCyc. # GO_process GO:0009408 response to heat; IEP:EcoliWiki. # GO_process GO:0033554 cellular response to stress; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # Gene3D 3.30.230.10 -; 1. # Gene3D 3.40.50.300 -; 1. # HAMAP MF_01973 lon_bact # INDUCTION LON_ECOLI By accumulation of abnormal proteins, such as at high temperatures. Under stress conditions. # INTERACTION LON_ECOLI P33225 torA; NbExp=2; IntAct=EBI-547203, EBI-557008; # IntAct P0A9M0 69 # InterPro IPR003111 LON_substr-bd_dom # InterPro IPR003593 AAA+_ATPase # InterPro IPR003959 ATPase_AAA_core # InterPro IPR004815 Lon_bac/euk-typ # InterPro IPR008268 Peptidase_S16_AS # InterPro IPR008269 Pept_S16_C # InterPro IPR014721 Ribosomal_S5_D2-typ_fold_subgr # InterPro IPR015947 PUA-like_domain # InterPro IPR020568 Ribosomal_S5_D2-typ_fold # InterPro IPR027065 Lon_Prtase # InterPro IPR027417 P-loop_NTPase # InterPro IPR027543 Lon_bac # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # KEGG_Pathway ko04112 Cell cycle - Caulobacter # MISCELLANEOUS LON_ECOLI Both high- and low-affinity ATPase sites are present in the homooligomer. Optimal peptidase activity requires ATP binding and hydrolysis at both sites, but ATP hydrolysis is not stoichiometrically linked to peptide hydrolysis. # MISCELLANEOUS LON_ECOLI Both its proteolytic and protein-activated ATPase activities are stimulated by DNA, especially single-stranded DNA. # Organism LON_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10046 PTHR10046 # PATRIC 32116031 VBIEscCol129921_0457 # PDB 1QZM X-ray; 1.90 A; A=491-584 # PDB 1RR9 X-ray; 2.10 A; A/B/C/D/E/F=585-784 # PDB 1RRE X-ray; 1.75 A; A/B/C/D/E/F=585-784 # PDB 2ANE X-ray; 2.03 A; A/B/C/D/E/F/G/H=1-118 # PDB 3LJC X-ray; 2.60 A; A=1-245 # PIR A23101 A23101 # PIR G64773 SUECLA # PIRSF PIRSF001174 Lon_proteas # PROSITE PS01046 LON_SER # PROSITE PS51786 LON_PROTEOLYTIC # PROSITE PS51787 LON_N # Pfam PF00004 AAA # Pfam PF02190 LON_substr_bdg # Pfam PF05362 Lon_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Lon protease {ECO:0000255|HAMAP-Rule MF_01973} # RefSeq NP_414973 NC_000913.3 # RefSeq WP_001295325 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA23537.1; Type=Frameshift; Positions=16; Evidence={ECO:0000305}; Sequence=AAB40195.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the peptidase S16 family. {ECO:0000255|HAMAP-Rule MF_01973}. # SIMILARITY Contains 1 Lon N-terminal domain. {ECO:0000255|PROSITE-ProRule PRU01123}. # SIMILARITY Contains 1 Lon proteolytic domain. {ECO:0000255|PROSITE-ProRule PRU01122}. # SMART SM00382 AAA # SMART SM00464 LON # SUBCELLULAR LOCATION LON_ECOLI Cytoplasm. # SUBUNIT LON_ECOLI Homohexamer. Organized in a ring with a central cavity. ATP binding and hydrolysis do not affect the oligomeric state of the enzyme. {ECO 0000255|HAMAP-Rule MF_01973, ECO 0000269|PubMed 16511355}. # SUPFAM SSF52540 SSF52540 # SUPFAM SSF54211 SSF54211 # SUPFAM SSF88697 SSF88697 # TIGRFAMs TIGR00763 lon # eggNOG COG0466 LUCA # eggNOG ENOG4105C6P Bacteria BLAST swissprot:LON_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LON_ECOLI BioCyc ECOL316407:JW0429-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0429-MONOMER BioCyc EcoCyc:EG10542-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10542-MONOMER BioCyc MetaCyc:EG10542-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10542-MONOMER COG COG0466 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0466 DIP DIP-35845N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35845N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0014-5793(94)01244-X http://dx.doi.org/10.1016/0014-5793(94)01244-X DOI 10.1016/0378-1119(93)90471-E http://dx.doi.org/10.1016/0378-1119(93)90471-E DOI 10.1016/S0014-5793(98)00012-X http://dx.doi.org/10.1016/S0014-5793(98)00012-X DOI 10.1016/j.jmb.2005.12.088 http://dx.doi.org/10.1016/j.jmb.2005.12.088 DOI 10.1016/j.jsb.2003.09.003 http://dx.doi.org/10.1016/j.jsb.2003.09.003 DOI 10.1021/bi0255470 http://dx.doi.org/10.1021/bi0255470 DOI 10.1021/bi052377t http://dx.doi.org/10.1021/bi052377t DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2003.03941.x http://dx.doi.org/10.1046/j.1365-2958.2003.03941.x DOI 10.1074/jbc.272.41.25678 http://dx.doi.org/10.1074/jbc.272.41.25678 DOI 10.1074/jbc.M113.510511 http://dx.doi.org/10.1074/jbc.M113.510511 DOI 10.1074/jbc.M312243200 http://dx.doi.org/10.1074/jbc.M312243200 DOI 10.1101/gad.12.24.3889 http://dx.doi.org/10.1101/gad.12.24.3889 DOI 10.1110/ps.051736805 http://dx.doi.org/10.1110/ps.051736805 DOI 10.1111/j.1365-2958.1994.tb00391.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb00391.x DOI 10.1111/j.1432-1033.2004.04421.x http://dx.doi.org/10.1111/j.1432-1033.2004.04421.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AAC.00787-09 http://dx.doi.org/10.1128/AAC.00787-09 DOI 10.1371/journal.pone.0039185 http://dx.doi.org/10.1371/journal.pone.0039185 EC_number EC:3.4.21.53 {ECO:0000255|HAMAP-Rule:MF_01973} http://www.genome.jp/dbget-bin/www_bget?EC:3.4.21.53 {ECO:0000255|HAMAP-Rule:MF_01973} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J03896 http://www.ebi.ac.uk/ena/data/view/J03896 EMBL L12349 http://www.ebi.ac.uk/ena/data/view/L12349 EMBL L20572 http://www.ebi.ac.uk/ena/data/view/L20572 EMBL M10153 http://www.ebi.ac.uk/ena/data/view/M10153 EMBL M38347 http://www.ebi.ac.uk/ena/data/view/M38347 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 ENZYME 3.4.21.53 {ECO:0000255|HAMAP-Rule:MF_01973} http://enzyme.expasy.org/EC/3.4.21.53 {ECO:0000255|HAMAP-Rule:MF_01973} EchoBASE EB0537 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0537 EcoGene EG10542 http://www.ecogene.org/geneInfo.php?eg_id=EG10542 EnsemblBacteria AAC73542 http://www.ensemblgenomes.org/id/AAC73542 EnsemblBacteria AAC73542 http://www.ensemblgenomes.org/id/AAC73542 EnsemblBacteria BAE76219 http://www.ensemblgenomes.org/id/BAE76219 EnsemblBacteria BAE76219 http://www.ensemblgenomes.org/id/BAE76219 EnsemblBacteria BAE76219 http://www.ensemblgenomes.org/id/BAE76219 EnsemblBacteria b0439 http://www.ensemblgenomes.org/id/b0439 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004176 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004176 GO_function GO:0004252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004252 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006508 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006508 GO_process GO:0006515 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006515 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GO_process GO:0033554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033554 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.30.230.10 http://www.cathdb.info/version/latest/superfamily/3.30.230.10 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945085 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945085 HAMAP MF_01973 http://hamap.expasy.org/unirule/MF_01973 HOGENOM HOG000261408 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261408&db=HOGENOM6 InParanoid P0A9M0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9M0 IntAct P0A9M0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9M0* IntEnz 3.4.21.53 {ECO:0000255|HAMAP-Rule:MF_01973} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.21.53 {ECO:0000255|HAMAP-Rule:MF_01973} InterPro IPR003111 http://www.ebi.ac.uk/interpro/entry/IPR003111 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR003959 http://www.ebi.ac.uk/interpro/entry/IPR003959 InterPro IPR004815 http://www.ebi.ac.uk/interpro/entry/IPR004815 InterPro IPR008268 http://www.ebi.ac.uk/interpro/entry/IPR008268 InterPro IPR008269 http://www.ebi.ac.uk/interpro/entry/IPR008269 InterPro IPR014721 http://www.ebi.ac.uk/interpro/entry/IPR014721 InterPro IPR015947 http://www.ebi.ac.uk/interpro/entry/IPR015947 InterPro IPR020568 http://www.ebi.ac.uk/interpro/entry/IPR020568 InterPro IPR027065 http://www.ebi.ac.uk/interpro/entry/IPR027065 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR027543 http://www.ebi.ac.uk/interpro/entry/IPR027543 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW0429 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0429 KEGG_Gene eco:b0439 http://www.genome.jp/dbget-bin/www_bget?eco:b0439 KEGG_Orthology KO:K01338 http://www.genome.jp/dbget-bin/www_bget?KO:K01338 KEGG_Pathway ko04112 http://www.genome.jp/kegg-bin/show_pathway?ko04112 MINT MINT-1224190 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1224190 OMA DRMDILR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DRMDILR PANTHER PTHR10046 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10046 PDB 1QZM http://www.ebi.ac.uk/pdbe-srv/view/entry/1QZM PDB 1RR9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1RR9 PDB 1RRE http://www.ebi.ac.uk/pdbe-srv/view/entry/1RRE PDB 2ANE http://www.ebi.ac.uk/pdbe-srv/view/entry/2ANE PDB 3LJC http://www.ebi.ac.uk/pdbe-srv/view/entry/3LJC PDBsum 1QZM http://www.ebi.ac.uk/pdbsum/1QZM PDBsum 1RR9 http://www.ebi.ac.uk/pdbsum/1RR9 PDBsum 1RRE http://www.ebi.ac.uk/pdbsum/1RRE PDBsum 2ANE http://www.ebi.ac.uk/pdbsum/2ANE PDBsum 3LJC http://www.ebi.ac.uk/pdbsum/3LJC PROSITE PS01046 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01046 PROSITE PS51786 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51786 PROSITE PS51787 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51787 PSORT swissprot:LON_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LON_ECOLI PSORT-B swissprot:LON_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LON_ECOLI PSORT2 swissprot:LON_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LON_ECOLI Pfam PF00004 http://pfam.xfam.org/family/PF00004 Pfam PF02190 http://pfam.xfam.org/family/PF02190 Pfam PF05362 http://pfam.xfam.org/family/PF05362 Phobius swissprot:LON_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LON_ECOLI PhylomeDB P0A9M0 http://phylomedb.org/?seqid=P0A9M0 ProteinModelPortal P0A9M0 http://www.proteinmodelportal.org/query/uniprot/P0A9M0 PubMed 10094703 http://www.ncbi.nlm.nih.gov/pubmed/10094703 PubMed 12135363 http://www.ncbi.nlm.nih.gov/pubmed/12135363 PubMed 14665623 http://www.ncbi.nlm.nih.gov/pubmed/14665623 PubMed 15009896 http://www.ncbi.nlm.nih.gov/pubmed/15009896 PubMed 15037242 http://www.ncbi.nlm.nih.gov/pubmed/15037242 PubMed 15560777 http://www.ncbi.nlm.nih.gov/pubmed/15560777 PubMed 16199667 http://www.ncbi.nlm.nih.gov/pubmed/16199667 PubMed 16460757 http://www.ncbi.nlm.nih.gov/pubmed/16460757 PubMed 16511355 http://www.ncbi.nlm.nih.gov/pubmed/16511355 PubMed 16584195 http://www.ncbi.nlm.nih.gov/pubmed/16584195 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19721064 http://www.ncbi.nlm.nih.gov/pubmed/19721064 PubMed 2242054 http://www.ncbi.nlm.nih.gov/pubmed/2242054 PubMed 22720069 http://www.ncbi.nlm.nih.gov/pubmed/22720069 PubMed 24375411 http://www.ncbi.nlm.nih.gov/pubmed/24375411 PubMed 2984174 http://www.ncbi.nlm.nih.gov/pubmed/2984174 PubMed 3042779 http://www.ncbi.nlm.nih.gov/pubmed/3042779 PubMed 3289547 http://www.ncbi.nlm.nih.gov/pubmed/3289547 PubMed 7988699 http://www.ncbi.nlm.nih.gov/pubmed/7988699 PubMed 8022284 http://www.ncbi.nlm.nih.gov/pubmed/8022284 PubMed 8226758 http://www.ncbi.nlm.nih.gov/pubmed/8226758 PubMed 8294008 http://www.ncbi.nlm.nih.gov/pubmed/8294008 PubMed 8995294 http://www.ncbi.nlm.nih.gov/pubmed/8995294 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9490010 http://www.ncbi.nlm.nih.gov/pubmed/9490010 PubMed 9869642 http://www.ncbi.nlm.nih.gov/pubmed/9869642 RefSeq NP_414973 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414973 RefSeq WP_001295325 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295325 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMART SM00464 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00464 SMR P0A9M0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9M0 STRING 511145.b0439 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0439&targetmode=cogs STRING COG0466 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0466&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SUPFAM SSF54211 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54211 SUPFAM SSF88697 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF88697 TIGRFAMs TIGR00763 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00763 UniProtKB LON_ECOLI http://www.uniprot.org/uniprot/LON_ECOLI UniProtKB-AC P0A9M0 http://www.uniprot.org/uniprot/P0A9M0 charge swissprot:LON_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LON_ECOLI eggNOG COG0466 http://eggnogapi.embl.de/nog_data/html/tree/COG0466 eggNOG ENOG4105C6P http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C6P epestfind swissprot:LON_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LON_ECOLI garnier swissprot:LON_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LON_ECOLI helixturnhelix swissprot:LON_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LON_ECOLI hmoment swissprot:LON_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LON_ECOLI iep swissprot:LON_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LON_ECOLI inforesidue swissprot:LON_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LON_ECOLI octanol swissprot:LON_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LON_ECOLI pepcoil swissprot:LON_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LON_ECOLI pepdigest swissprot:LON_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LON_ECOLI pepinfo swissprot:LON_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LON_ECOLI pepnet swissprot:LON_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LON_ECOLI pepstats swissprot:LON_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LON_ECOLI pepwheel swissprot:LON_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LON_ECOLI pepwindow swissprot:LON_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LON_ECOLI sigcleave swissprot:LON_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LON_ECOLI ## Database ID URL or Descriptions # BioGrid 4263080 2 # EcoGene EG11966 adiY # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0000987 core promoter proximal region sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.60 -; 1. # IntAct P33234 2 # InterPro IPR009057 Homeodomain-like # InterPro IPR018060 HTH_AraC # InterPro IPR018062 HTH_AraC-typ_CS # InterPro IPR020449 Tscrpt_reg_HTH_AraC-type # KEGG_Brite ko03000 Transcription factors # Organism ADIY_ECOLI Escherichia coli (strain K12) # PATRIC 32123797 VBIEscCol129921_4247 # PIR S56345 S56345 # PRINTS PR00032 HTHARAC # PROSITE PS00041 HTH_ARAC_FAMILY_1 # PROSITE PS01124 HTH_ARAC_FAMILY_2 # Pfam PF12833 HTH_18 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ADIY_ECOLI HTH-type transcriptional regulator AdiY # RefSeq NP_418540 NC_000913.3 # RefSeq WP_001217060 NZ_LN832404.1 # SIMILARITY Contains 1 HTH araC/xylS-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00593}. # SMART SM00342 HTH_ARAC # SUPFAM SSF46689 SSF46689 # eggNOG ENOG4106ZGR Bacteria # eggNOG ENOG4110B0F LUCA BLAST swissprot:ADIY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ADIY_ECOLI BioCyc ECOL316407:JW4077-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4077-MONOMER BioCyc EcoCyc:EG11966-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11966-MONOMER COG COG2207 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2207 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U02384 http://www.ebi.ac.uk/ena/data/view/U02384 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB1909 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1909 EcoGene EG11966 http://www.ecogene.org/geneInfo.php?eg_id=EG11966 EnsemblBacteria AAC77077 http://www.ensemblgenomes.org/id/AAC77077 EnsemblBacteria AAC77077 http://www.ensemblgenomes.org/id/AAC77077 EnsemblBacteria BAE78118 http://www.ensemblgenomes.org/id/BAE78118 EnsemblBacteria BAE78118 http://www.ensemblgenomes.org/id/BAE78118 EnsemblBacteria BAE78118 http://www.ensemblgenomes.org/id/BAE78118 EnsemblBacteria b4116 http://www.ensemblgenomes.org/id/b4116 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000987 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000987 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 GeneID 948627 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948627 HOGENOM HOG000127052 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000127052&db=HOGENOM6 InParanoid P33234 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33234 IntAct P33234 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33234* InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR018060 http://www.ebi.ac.uk/interpro/entry/IPR018060 InterPro IPR018062 http://www.ebi.ac.uk/interpro/entry/IPR018062 InterPro IPR020449 http://www.ebi.ac.uk/interpro/entry/IPR020449 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW4077 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4077 KEGG_Gene eco:b4116 http://www.genome.jp/dbget-bin/www_bget?eco:b4116 KEGG_Orthology KO:K03755 http://www.genome.jp/dbget-bin/www_bget?KO:K03755 OMA SDIHKEW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SDIHKEW PRINTS PR00032 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00032 PROSITE PS00041 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00041 PROSITE PS01124 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01124 PSORT swissprot:ADIY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ADIY_ECOLI PSORT-B swissprot:ADIY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ADIY_ECOLI PSORT2 swissprot:ADIY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ADIY_ECOLI Pfam PF12833 http://pfam.xfam.org/family/PF12833 Phobius swissprot:ADIY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ADIY_ECOLI PhylomeDB P33234 http://phylomedb.org/?seqid=P33234 ProteinModelPortal P33234 http://www.proteinmodelportal.org/query/uniprot/P33234 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418540 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418540 RefSeq WP_001217060 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001217060 SMART SM00342 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00342 SMR P33234 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33234 STRING 511145.b4116 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4116&targetmode=cogs STRING COG2207 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2207&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 UniProtKB ADIY_ECOLI http://www.uniprot.org/uniprot/ADIY_ECOLI UniProtKB-AC P33234 http://www.uniprot.org/uniprot/P33234 charge swissprot:ADIY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ADIY_ECOLI eggNOG ENOG4106ZGR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106ZGR eggNOG ENOG4110B0F http://eggnogapi.embl.de/nog_data/html/tree/ENOG4110B0F epestfind swissprot:ADIY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ADIY_ECOLI garnier swissprot:ADIY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ADIY_ECOLI helixturnhelix swissprot:ADIY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ADIY_ECOLI hmoment swissprot:ADIY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ADIY_ECOLI iep swissprot:ADIY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ADIY_ECOLI inforesidue swissprot:ADIY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ADIY_ECOLI octanol swissprot:ADIY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ADIY_ECOLI pepcoil swissprot:ADIY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ADIY_ECOLI pepdigest swissprot:ADIY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ADIY_ECOLI pepinfo swissprot:ADIY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ADIY_ECOLI pepnet swissprot:ADIY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ADIY_ECOLI pepstats swissprot:ADIY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ADIY_ECOLI pepwheel swissprot:ADIY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ADIY_ECOLI pepwindow swissprot:ADIY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ADIY_ECOLI sigcleave swissprot:ADIY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ADIY_ECOLI ## Database ID URL or Descriptions # BioGrid 4260245 130 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG13836 ydfX # Gene3D 1.10.3600.10 -; 1. # IntAct P76165 5 # InterPro IPR009364 YdaT_toxin # Organism YDFX_ECOLI Escherichia coli (strain K12) # PATRIC 48662449 VBIEscCol107702_1585 # PIR C64912 C64912 # Pfam PF06254 YdaT_toxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDFX_ECOLI Uncharacterized protein YdfX # RefSeq WP_001350513 NZ_LN832404.1 BLAST swissprot:YDFX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDFX_ECOLI BioCyc ECOL316407:JW1560-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1560-MONOMER BioCyc EcoCyc:G6835-MONOMER http://biocyc.org/getid?id=EcoCyc:G6835-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3597 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3597 EcoGene EG13836 http://www.ecogene.org/geneInfo.php?eg_id=EG13836 EnsemblBacteria BAE76474 http://www.ensemblgenomes.org/id/BAE76474 EnsemblBacteria BAE76474 http://www.ensemblgenomes.org/id/BAE76474 EnsemblBacteria BAE76474 http://www.ensemblgenomes.org/id/BAE76474 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 1.10.3600.10 http://www.cathdb.info/version/latest/superfamily/1.10.3600.10 IntAct P76165 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76165* InterPro IPR009364 http://www.ebi.ac.uk/interpro/entry/IPR009364 KEGG_Gene ecj:JW1560 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1560 OMA ITESFWA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ITESFWA PSORT swissprot:YDFX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDFX_ECOLI PSORT-B swissprot:YDFX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDFX_ECOLI PSORT2 swissprot:YDFX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDFX_ECOLI Pfam PF06254 http://pfam.xfam.org/family/PF06254 Phobius swissprot:YDFX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDFX_ECOLI ProteinModelPortal P76165 http://www.proteinmodelportal.org/query/uniprot/P76165 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001350513 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001350513 SMR P76165 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76165 STRING 316407.85675027 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85675027&targetmode=cogs UniProtKB YDFX_ECOLI http://www.uniprot.org/uniprot/YDFX_ECOLI UniProtKB-AC P76165 http://www.uniprot.org/uniprot/P76165 charge swissprot:YDFX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDFX_ECOLI epestfind swissprot:YDFX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDFX_ECOLI garnier swissprot:YDFX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDFX_ECOLI helixturnhelix swissprot:YDFX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDFX_ECOLI hmoment swissprot:YDFX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDFX_ECOLI iep swissprot:YDFX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDFX_ECOLI inforesidue swissprot:YDFX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDFX_ECOLI octanol swissprot:YDFX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDFX_ECOLI pepcoil swissprot:YDFX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDFX_ECOLI pepdigest swissprot:YDFX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDFX_ECOLI pepinfo swissprot:YDFX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDFX_ECOLI pepnet swissprot:YDFX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDFX_ECOLI pepstats swissprot:YDFX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDFX_ECOLI pepwheel swissprot:YDFX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDFX_ECOLI pepwindow swissprot:YDFX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDFX_ECOLI sigcleave swissprot:YDFX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDFX_ECOLI ## Database ID URL or Descriptions # BioGrid 4261679 13 # CATALYTIC ACTIVITY IMP + diphosphate = hypoxanthine + 5-phospho- alpha-D-ribose 1-diphosphate. {ECO:0000269|PubMed 12070315}. # CDD cd06223 PRTases_typeI # COFACTOR HPRT_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250}; Note=Binds 2 magnesium ions per subunit. The magnesium ions are essentially bound to the substrate and have few direct interactions with the protein. {ECO 0000250}; # EcoGene EG20098 hpt # FUNCTION HPRT_ECOLI Acts preferentially on hypoxanthine; has very low activity towards guanine. Inactive towards xanthine. {ECO 0000269|PubMed 12070315}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000166 nucleotide binding; IEA:UniProtKB-KW. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0004422 hypoxanthine phosphoribosyltransferase activity; IDA:EcoCyc. # GO_function GO:0052657 guanine phosphoribosyltransferase activity; IEA:UniProtKB-EC. # GO_process GO:0032263 GMP salvage; IDA:EcoliWiki. # GO_process GO:0032264 IMP salvage; IDA:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.2020 -; 1. # IntAct P0A9M2 5 # InterPro IPR000836 PRibTrfase_dom # InterPro IPR005904 Hxn_phspho_trans # InterPro IPR029057 PRTase-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00983 Drug metabolism - other enzymes # Organism HPRT_ECOLI Escherichia coli (strain K12) # PATHWAY Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine step 1/1. # PATRIC 32115353 VBIEscCol129921_0128 # PDB 1G9S X-ray; 2.80 A; A/B=1-178 # PDB 1G9T X-ray; 2.80 A; A/B=1-178 # PDB 1GRV X-ray; 2.90 A; A/B=1-178 # PROSITE PS00103 PUR_PYR_PR_TRANSFER # Pfam PF00156 Pribosyltran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HPRT_ECOLI Hypoxanthine phosphoribosyltransferase # RefSeq NP_414667 NC_000913.3 # RefSeq WP_000683335 NZ_LN832404.1 # SIMILARITY Belongs to the purine/pyrimidine phosphoribosyltransferase family. {ECO 0000305}. # SUBCELLULAR LOCATION HPRT_ECOLI Cytoplasm. # SUBUNIT Homotetramer. {ECO:0000269|PubMed 12070315}. # SUPFAM SSF53271 SSF53271 # TIGRFAMs TIGR01203 HGPRTase # UniPathway UPA00591 UER00648 # eggNOG COG0634 LUCA # eggNOG ENOG4108UGV Bacteria BLAST swissprot:HPRT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HPRT_ECOLI BioCyc ECOL316407:JW5009-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5009-MONOMER BioCyc EcoCyc:HYPOXANPRIBOSYLTRAN-MONOMER http://biocyc.org/getid?id=EcoCyc:HYPOXANPRIBOSYLTRAN-MONOMER BioCyc MetaCyc:HYPOXANPRIBOSYLTRAN-MONOMER http://biocyc.org/getid?id=MetaCyc:HYPOXANPRIBOSYLTRAN-MONOMER COG COG0634 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0634 DIP DIP-47994N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47994N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1110/ps.0201002 http://dx.doi.org/10.1110/ps.0201002 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.4.2.8 http://www.genome.jp/dbget-bin/www_bget?EC:2.4.2.8 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.4.2.8 http://enzyme.expasy.org/EC/2.4.2.8 EchoBASE EB4143 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4143 EcoGene EG20098 http://www.ecogene.org/geneInfo.php?eg_id=EG20098 EnsemblBacteria AAC73236 http://www.ensemblgenomes.org/id/AAC73236 EnsemblBacteria AAC73236 http://www.ensemblgenomes.org/id/AAC73236 EnsemblBacteria BAB96700 http://www.ensemblgenomes.org/id/BAB96700 EnsemblBacteria BAB96700 http://www.ensemblgenomes.org/id/BAB96700 EnsemblBacteria BAB96700 http://www.ensemblgenomes.org/id/BAB96700 EnsemblBacteria b0125 http://www.ensemblgenomes.org/id/b0125 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000166 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000166 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0004422 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004422 GO_function GO:0052657 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052657 GO_process GO:0032263 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032263 GO_process GO:0032264 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032264 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.2020 http://www.cathdb.info/version/latest/superfamily/3.40.50.2020 GeneID 946624 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946624 HOGENOM HOG000236520 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000236520&db=HOGENOM6 InParanoid P0A9M2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9M2 IntAct P0A9M2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9M2* IntEnz 2.4.2.8 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.2.8 InterPro IPR000836 http://www.ebi.ac.uk/interpro/entry/IPR000836 InterPro IPR005904 http://www.ebi.ac.uk/interpro/entry/IPR005904 InterPro IPR029057 http://www.ebi.ac.uk/interpro/entry/IPR029057 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5009 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5009 KEGG_Gene eco:b0125 http://www.genome.jp/dbget-bin/www_bget?eco:b0125 KEGG_Orthology KO:K00760 http://www.genome.jp/dbget-bin/www_bget?KO:K00760 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00983 http://www.genome.jp/kegg-bin/show_pathway?ko00983 KEGG_Reaction rn:R00190 http://www.genome.jp/dbget-bin/www_bget?rn:R00190 KEGG_Reaction rn:R01132 http://www.genome.jp/dbget-bin/www_bget?rn:R01132 KEGG_Reaction rn:R01229 http://www.genome.jp/dbget-bin/www_bget?rn:R01229 KEGG_Reaction rn:R02142 http://www.genome.jp/dbget-bin/www_bget?rn:R02142 KEGG_Reaction rn:R08237 http://www.genome.jp/dbget-bin/www_bget?rn:R08237 KEGG_Reaction rn:R08238 http://www.genome.jp/dbget-bin/www_bget?rn:R08238 KEGG_Reaction rn:R08245 http://www.genome.jp/dbget-bin/www_bget?rn:R08245 OMA TPVTMDW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TPVTMDW PDB 1G9S http://www.ebi.ac.uk/pdbe-srv/view/entry/1G9S PDB 1G9T http://www.ebi.ac.uk/pdbe-srv/view/entry/1G9T PDB 1GRV http://www.ebi.ac.uk/pdbe-srv/view/entry/1GRV PDBsum 1G9S http://www.ebi.ac.uk/pdbsum/1G9S PDBsum 1G9T http://www.ebi.ac.uk/pdbsum/1G9T PDBsum 1GRV http://www.ebi.ac.uk/pdbsum/1GRV PROSITE PS00103 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00103 PSORT swissprot:HPRT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HPRT_ECOLI PSORT-B swissprot:HPRT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HPRT_ECOLI PSORT2 swissprot:HPRT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HPRT_ECOLI Pfam PF00156 http://pfam.xfam.org/family/PF00156 Phobius swissprot:HPRT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HPRT_ECOLI PhylomeDB P0A9M2 http://phylomedb.org/?seqid=P0A9M2 ProteinModelPortal P0A9M2 http://www.proteinmodelportal.org/query/uniprot/P0A9M2 PubMed 12070315 http://www.ncbi.nlm.nih.gov/pubmed/12070315 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414667 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414667 RefSeq WP_000683335 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000683335 SMR P0A9M2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9M2 STRING 511145.b0125 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0125&targetmode=cogs STRING COG0634 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0634&targetmode=cogs SUPFAM SSF53271 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53271 SWISS-2DPAGE P0A9M2 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A9M2 TIGRFAMs TIGR01203 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01203 UniProtKB HPRT_ECOLI http://www.uniprot.org/uniprot/HPRT_ECOLI UniProtKB-AC P0A9M2 http://www.uniprot.org/uniprot/P0A9M2 charge swissprot:HPRT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HPRT_ECOLI eggNOG COG0634 http://eggnogapi.embl.de/nog_data/html/tree/COG0634 eggNOG ENOG4108UGV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UGV epestfind swissprot:HPRT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HPRT_ECOLI garnier swissprot:HPRT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HPRT_ECOLI helixturnhelix swissprot:HPRT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HPRT_ECOLI hmoment swissprot:HPRT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HPRT_ECOLI iep swissprot:HPRT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HPRT_ECOLI inforesidue swissprot:HPRT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HPRT_ECOLI octanol swissprot:HPRT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HPRT_ECOLI pepcoil swissprot:HPRT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HPRT_ECOLI pepdigest swissprot:HPRT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HPRT_ECOLI pepinfo swissprot:HPRT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HPRT_ECOLI pepnet swissprot:HPRT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HPRT_ECOLI pepstats swissprot:HPRT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HPRT_ECOLI pepwheel swissprot:HPRT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HPRT_ECOLI pepwindow swissprot:HPRT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HPRT_ECOLI sigcleave swissprot:HPRT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HPRT_ECOLI ## Database ID URL or Descriptions # AltName 5-enolpyruvylshikimate-3-phosphate synthase {ECO:0000255|HAMAP-Rule MF_00210, ECO:0000303|Ref.1} # BIOPHYSICOCHEMICAL PROPERTIES AROA_ECOLI Kinetic parameters KM=0.0035 mM for S3P (at pH 7 and 25 degrees Celsius {ECO 0000269|PubMed 6229418}; KM=0.015 mM for PEP (at pH 7 and 25 degrees Celsius {ECO 0000269|PubMed 6229418}; KM=0.045 mM for PEP (at pH 7.5 and 25 degrees Celsius {ECO 0000269|PubMed 19211556}; KM=0.048 mM for S3P (at pH 7.5 and 25 degrees Celsius {ECO 0000269|PubMed 19211556}; KM=0.06 mM for PEP (at pH 7.5 and 25 degrees Celsius {ECO 0000269|PubMed 17855366}; KM=0.06 mM for S3P (at pH 7.5 and 25 degrees Celsius {ECO 0000269|PubMed 17855366}; KM=0.088 mM for PEP (at pH 6.8 and 20 degrees Celsius {ECO 0000269|PubMed 12430021}; KM=0.09 mM for S3P (at pH 5.5 and 20 degrees Celsius {ECO 0000269|PubMed 16225867}; KM=0.1 mM for PEP (at pH 5.5 and 20 degrees Celsius {ECO 0000269|PubMed 16225867}; KM=0.12 mM for S3P (at pH 6.8 and 20 degrees Celsius {ECO 0000269|PubMed 12430021}; Vmax=50 umol/min/ug enzyme (at pH 7.5 and 25 degrees Celsius {ECO 0000269|PubMed 17855366}; Vmax=53 umol/min/ug enzyme (at pH 5.5 and 20 degrees Celsius {ECO 0000269|PubMed 16225867}; Vmax=57 umol/min/ug enzyme (at pH 7.5 and 25 degrees Celsius {ECO 0000269|PubMed 19211556}; pH dependence Optimum pH is between 6 and 6.5. {ECO 0000269|PubMed 12430021, ECO 0000269|PubMed 16225867, ECO 0000269|PubMed 17855366, ECO 0000269|PubMed 19211556, ECO 0000269|PubMed 6229418}; # BRENDA 2.5.1.19 2026 # BioGrid 4260011 10 # CATALYTIC ACTIVITY AROA_ECOLI Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. {ECO 0000255|HAMAP-Rule MF_00210, ECO 0000269|PubMed 12430021, ECO 0000269|PubMed 13129913, ECO 0000269|PubMed 16225867, ECO 0000269|PubMed 17855366, ECO 0000269|PubMed 17958399, ECO 0000269|PubMed 19211556, ECO 0000269|PubMed 6229418}. # ENZYME REGULATION AROA_ECOLI Competitively inhibited by glyphosate (PubMed 12430021, PubMed 6229418). Inhibited by (S)- and (R)- phosphonates analogs (PubMed 15736934). Inhibited by (R)- difluoromethyl analogs of the tetrahedral reaction intermediate (PubMed 16225867). Inhibited by bromopyruvate (PubMed 1899181). {ECO 0000269|PubMed 12430021, ECO 0000269|PubMed 15736934, ECO 0000269|PubMed 16225867, ECO 0000269|PubMed 17958399, ECO 0000269|PubMed 1899181, ECO 0000269|PubMed 6229418}. # EcoGene EG10073 aroA # FUNCTION AROA_ECOLI Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. {ECO 0000255|HAMAP-Rule MF_00210, ECO 0000269|PubMed 12430021, ECO 0000269|PubMed 13129913, ECO 0000269|PubMed 16225867, ECO 0000269|PubMed 17855366, ECO 0000269|PubMed 17958399, ECO 0000269|PubMed 19211556, ECO 0000269|PubMed 6229418}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003866 3-phosphoshikimate 1-carboxyvinyltransferase activity; IDA:UniProtKB. # GO_process GO:0008652 cellular amino acid biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0009073 aromatic amino acid family biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0009423 chorismate biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.65.10.10 -; 2. # HAMAP MF_00210 EPSP_synth # IntAct P0A6D3 3 # InterPro IPR001986 Enolpyruvate_Tfrase_dom # InterPro IPR006264 EPSP_synthase # InterPro IPR013792 RNA3'P_cycl/enolpyr_Trfase_a/b # InterPro IPR023193 EPSP_synthase_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis # Organism AROA_ECOLI Escherichia coli (strain K12) # PATHWAY AROA_ECOLI Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate step 6/7. {ECO 0000255|HAMAP-Rule MF_00210, ECO 0000305}. # PATRIC 32117029 VBIEscCol129921_0939 # PDB 1EPS X-ray; 3.00 A; A=1-427 # PDB 1G6S X-ray; 1.50 A; A=1-427 # PDB 1G6T X-ray; 1.60 A; A=1-427 # PDB 1MI4 X-ray; 1.70 A; A=1-427 # PDB 1P88 NMR; -; A=25-240 # PDB 1P89 NMR; -; A=25-240 # PDB 1Q0I Model; -; A=1-427 # PDB 1Q0J Model; -; A=1-427 # PDB 1Q36 X-ray; 1.60 A; A=1-427 # PDB 1X8R X-ray; 1.50 A; A=1-427 # PDB 1X8T X-ray; 1.90 A; A=1-427 # PDB 2AA9 X-ray; 1.50 A; A=1-427 # PDB 2AAY X-ray; 1.55 A; A=1-427 # PDB 2PQ9 X-ray; 1.60 A; A=1-427 # PDB 2QFQ X-ray; 1.50 A; A=1-427 # PDB 2QFS X-ray; 1.55 A; A=1-427 # PDB 2QFT X-ray; 1.55 A; A=1-427 # PDB 2QFU X-ray; 1.60 A; A=1-427 # PDB 3FJX X-ray; 1.75 A; A=1-427 # PDB 3FJZ X-ray; 1.70 A; A=1-427 # PDB 3FK0 X-ray; 1.70 A; A=1-427 # PDB 3FK1 X-ray; 1.70 A; A=1-427 # PIR C64830 XUECVS # PIRSF PIRSF000505 EPSPS # PROSITE PS00104 EPSP_SYNTHASE_1 # PROSITE PS00885 EPSP_SYNTHASE_2 # Pfam PF00275 EPSP_synthase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 3-phosphoshikimate 1-carboxyvinyltransferase {ECO:0000255|HAMAP-Rule MF_00210} # RefSeq NP_415428 NC_000913.3 # RefSeq WP_000445231 NZ_LN832404.1 # SIMILARITY Belongs to the EPSP synthase family. {ECO:0000255|HAMAP-Rule MF_00210, ECO:0000305}. # SUBCELLULAR LOCATION AROA_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00210, ECO 0000305}. # SUBUNIT AROA_ECOLI Monomer. {ECO 0000255|HAMAP-Rule MF_00210, ECO 0000269|PubMed 6229418}. # SUPFAM SSF55205 SSF55205 # TIGRFAMs TIGR01356 aroA # UniPathway UPA00053 UER00089 # eggNOG COG0128 LUCA # eggNOG ENOG4105CMY Bacteria BLAST swissprot:AROA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AROA_ECOLI BioCyc ECOL316407:JW0891-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0891-MONOMER BioCyc EcoCyc:AROA-MONOMER http://biocyc.org/getid?id=EcoCyc:AROA-MONOMER BioCyc MetaCyc:AROA-MONOMER http://biocyc.org/getid?id=MetaCyc:AROA-MONOMER COG COG0128 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0128 DIP DIP-48256N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48256N DOI 10.1007/s00425-002-0908-0 http://dx.doi.org/10.1007/s00425-002-0908-0 DOI 10.1016/0003-9861(91)90316-B http://dx.doi.org/10.1016/0003-9861(91)90316-B DOI 10.1016/0014-5793(84)80027-7 http://dx.doi.org/10.1016/0014-5793(84)80027-7 DOI 10.1016/j.febslet.2005.09.066 http://dx.doi.org/10.1016/j.febslet.2005.09.066 DOI 10.1021/bi048198d http://dx.doi.org/10.1021/bi048198d DOI 10.1021/bi701095u http://dx.doi.org/10.1021/bi701095u DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2900525 http://dx.doi.org/10.1042/bj2900525 DOI 10.1073/pnas.88.11.5046 http://dx.doi.org/10.1073/pnas.88.11.5046 DOI 10.1073/pnas.98.4.1376 http://dx.doi.org/10.1073/pnas.98.4.1376 DOI 10.1074/jbc.M309741200 http://dx.doi.org/10.1074/jbc.M309741200 DOI 10.1074/jbc.M705624200 http://dx.doi.org/10.1074/jbc.M705624200 DOI 10.1074/jbc.M809771200 http://dx.doi.org/10.1074/jbc.M809771200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.5.1.19 {ECO:0000255|HAMAP-Rule:MF_00210, ECO:0000269|PubMed:12430021, ECO:0000269|PubMed:13129913, ECO:0000269|PubMed:16225867, ECO:0000269|PubMed:17855366, ECO:0000269|PubMed:19211556, ECO:0000269|PubMed:6229418} http://www.genome.jp/dbget-bin/www_bget?EC:2.5.1.19 {ECO:0000255|HAMAP-Rule:MF_00210, ECO:0000269|PubMed:12430021, ECO:0000269|PubMed:13129913, ECO:0000269|PubMed:16225867, ECO:0000269|PubMed:17855366, ECO:0000269|PubMed:19211556, ECO:0000269|PubMed:6229418} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U31523 http://www.ebi.ac.uk/ena/data/view/U31523 EMBL X00557 http://www.ebi.ac.uk/ena/data/view/X00557 ENZYME 2.5.1.19 {ECO:0000255|HAMAP-Rule:MF_00210, ECO:0000269|PubMed:12430021, ECO:0000269|PubMed:13129913, ECO:0000269|PubMed:16225867, ECO:0000269|PubMed:17855366, ECO:0000269|PubMed:19211556, ECO:0000269|PubMed:6229418} http://enzyme.expasy.org/EC/2.5.1.19 {ECO:0000255|HAMAP-Rule:MF_00210, ECO:0000269|PubMed:12430021, ECO:0000269|PubMed:13129913, ECO:0000269|PubMed:16225867, ECO:0000269|PubMed:17855366, ECO:0000269|PubMed:19211556, ECO:0000269|PubMed:6229418} EchoBASE EB0071 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0071 EcoGene EG10073 http://www.ecogene.org/geneInfo.php?eg_id=EG10073 EnsemblBacteria AAC73994 http://www.ensemblgenomes.org/id/AAC73994 EnsemblBacteria AAC73994 http://www.ensemblgenomes.org/id/AAC73994 EnsemblBacteria BAA35643 http://www.ensemblgenomes.org/id/BAA35643 EnsemblBacteria BAA35643 http://www.ensemblgenomes.org/id/BAA35643 EnsemblBacteria BAA35643 http://www.ensemblgenomes.org/id/BAA35643 EnsemblBacteria b0908 http://www.ensemblgenomes.org/id/b0908 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003866 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003866 GO_process GO:0008652 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008652 GO_process GO:0009073 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009073 GO_process GO:0009423 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009423 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016765 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.65.10.10 http://www.cathdb.info/version/latest/superfamily/3.65.10.10 GeneID 945528 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945528 HAMAP MF_00210 http://hamap.expasy.org/unirule/MF_00210 HOGENOM HOG000247372 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000247372&db=HOGENOM6 InParanoid P0A6D3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6D3 IntAct P0A6D3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6D3* IntEnz 2.5.1.19 {ECO:0000255|HAMAP-Rule:MF_00210, ECO:0000269|PubMed:12430021, ECO:0000269|PubMed:13129913, ECO:0000269|PubMed:16225867, ECO:0000269|PubMed:17855366, ECO:0000269|PubMed:19211556, ECO:0000269|PubMed:6229418} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.5.1.19 {ECO:0000255|HAMAP-Rule:MF_00210, ECO:0000269|PubMed:12430021, ECO:0000269|PubMed:13129913, ECO:0000269|PubMed:16225867, ECO:0000269|PubMed:17855366, ECO:0000269|PubMed:19211556, ECO:0000269|PubMed:6229418} InterPro IPR001986 http://www.ebi.ac.uk/interpro/entry/IPR001986 InterPro IPR006264 http://www.ebi.ac.uk/interpro/entry/IPR006264 InterPro IPR013792 http://www.ebi.ac.uk/interpro/entry/IPR013792 InterPro IPR023193 http://www.ebi.ac.uk/interpro/entry/IPR023193 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0891 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0891 KEGG_Gene eco:b0908 http://www.genome.jp/dbget-bin/www_bget?eco:b0908 KEGG_Orthology KO:K00800 http://www.genome.jp/dbget-bin/www_bget?KO:K00800 KEGG_Pathway ko00400 http://www.genome.jp/kegg-bin/show_pathway?ko00400 KEGG_Reaction rn:R03460 http://www.genome.jp/dbget-bin/www_bget?rn:R03460 OMA ETDHRVA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ETDHRVA PDB 1EPS http://www.ebi.ac.uk/pdbe-srv/view/entry/1EPS PDB 1G6S http://www.ebi.ac.uk/pdbe-srv/view/entry/1G6S PDB 1G6T http://www.ebi.ac.uk/pdbe-srv/view/entry/1G6T PDB 1MI4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1MI4 PDB 1P88 http://www.ebi.ac.uk/pdbe-srv/view/entry/1P88 PDB 1P89 http://www.ebi.ac.uk/pdbe-srv/view/entry/1P89 PDB 1Q0I http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q0I PDB 1Q0J http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q0J PDB 1Q36 http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q36 PDB 1X8R http://www.ebi.ac.uk/pdbe-srv/view/entry/1X8R PDB 1X8T http://www.ebi.ac.uk/pdbe-srv/view/entry/1X8T PDB 2AA9 http://www.ebi.ac.uk/pdbe-srv/view/entry/2AA9 PDB 2AAY http://www.ebi.ac.uk/pdbe-srv/view/entry/2AAY PDB 2PQ9 http://www.ebi.ac.uk/pdbe-srv/view/entry/2PQ9 PDB 2QFQ http://www.ebi.ac.uk/pdbe-srv/view/entry/2QFQ PDB 2QFS http://www.ebi.ac.uk/pdbe-srv/view/entry/2QFS PDB 2QFT http://www.ebi.ac.uk/pdbe-srv/view/entry/2QFT PDB 2QFU http://www.ebi.ac.uk/pdbe-srv/view/entry/2QFU PDB 3FJX http://www.ebi.ac.uk/pdbe-srv/view/entry/3FJX PDB 3FJZ http://www.ebi.ac.uk/pdbe-srv/view/entry/3FJZ PDB 3FK0 http://www.ebi.ac.uk/pdbe-srv/view/entry/3FK0 PDB 3FK1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3FK1 PDBsum 1EPS http://www.ebi.ac.uk/pdbsum/1EPS PDBsum 1G6S http://www.ebi.ac.uk/pdbsum/1G6S PDBsum 1G6T http://www.ebi.ac.uk/pdbsum/1G6T PDBsum 1MI4 http://www.ebi.ac.uk/pdbsum/1MI4 PDBsum 1P88 http://www.ebi.ac.uk/pdbsum/1P88 PDBsum 1P89 http://www.ebi.ac.uk/pdbsum/1P89 PDBsum 1Q0I http://www.ebi.ac.uk/pdbsum/1Q0I PDBsum 1Q0J http://www.ebi.ac.uk/pdbsum/1Q0J PDBsum 1Q36 http://www.ebi.ac.uk/pdbsum/1Q36 PDBsum 1X8R http://www.ebi.ac.uk/pdbsum/1X8R PDBsum 1X8T http://www.ebi.ac.uk/pdbsum/1X8T PDBsum 2AA9 http://www.ebi.ac.uk/pdbsum/2AA9 PDBsum 2AAY http://www.ebi.ac.uk/pdbsum/2AAY PDBsum 2PQ9 http://www.ebi.ac.uk/pdbsum/2PQ9 PDBsum 2QFQ http://www.ebi.ac.uk/pdbsum/2QFQ PDBsum 2QFS http://www.ebi.ac.uk/pdbsum/2QFS PDBsum 2QFT http://www.ebi.ac.uk/pdbsum/2QFT PDBsum 2QFU http://www.ebi.ac.uk/pdbsum/2QFU PDBsum 3FJX http://www.ebi.ac.uk/pdbsum/3FJX PDBsum 3FJZ http://www.ebi.ac.uk/pdbsum/3FJZ PDBsum 3FK0 http://www.ebi.ac.uk/pdbsum/3FK0 PDBsum 3FK1 http://www.ebi.ac.uk/pdbsum/3FK1 PROSITE PS00104 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00104 PROSITE PS00885 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00885 PSORT swissprot:AROA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AROA_ECOLI PSORT-B swissprot:AROA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AROA_ECOLI PSORT2 swissprot:AROA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AROA_ECOLI Pfam PF00275 http://pfam.xfam.org/family/PF00275 Phobius swissprot:AROA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AROA_ECOLI PhylomeDB P0A6D3 http://phylomedb.org/?seqid=P0A6D3 ProteinModelPortal P0A6D3 http://www.proteinmodelportal.org/query/uniprot/P0A6D3 PubMed 11171958 http://www.ncbi.nlm.nih.gov/pubmed/11171958 PubMed 11607190 http://www.ncbi.nlm.nih.gov/pubmed/11607190 PubMed 12430021 http://www.ncbi.nlm.nih.gov/pubmed/12430021 PubMed 13129913 http://www.ncbi.nlm.nih.gov/pubmed/13129913 PubMed 15736934 http://www.ncbi.nlm.nih.gov/pubmed/15736934 PubMed 16225867 http://www.ncbi.nlm.nih.gov/pubmed/16225867 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17855366 http://www.ncbi.nlm.nih.gov/pubmed/17855366 PubMed 17958399 http://www.ncbi.nlm.nih.gov/pubmed/17958399 PubMed 1899181 http://www.ncbi.nlm.nih.gov/pubmed/1899181 PubMed 19211556 http://www.ncbi.nlm.nih.gov/pubmed/19211556 PubMed 6229418 http://www.ncbi.nlm.nih.gov/pubmed/6229418 PubMed 8452542 http://www.ncbi.nlm.nih.gov/pubmed/8452542 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415428 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415428 RefSeq WP_000445231 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000445231 SMR P0A6D3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6D3 STRING 511145.b0908 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0908&targetmode=cogs STRING COG0128 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0128&targetmode=cogs SUPFAM SSF55205 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55205 SWISS-2DPAGE P0A6D3 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A6D3 TIGRFAMs TIGR01356 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01356 UniProtKB AROA_ECOLI http://www.uniprot.org/uniprot/AROA_ECOLI UniProtKB-AC P0A6D3 http://www.uniprot.org/uniprot/P0A6D3 charge swissprot:AROA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AROA_ECOLI eggNOG COG0128 http://eggnogapi.embl.de/nog_data/html/tree/COG0128 eggNOG ENOG4105CMY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CMY epestfind swissprot:AROA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AROA_ECOLI garnier swissprot:AROA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AROA_ECOLI helixturnhelix swissprot:AROA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AROA_ECOLI hmoment swissprot:AROA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AROA_ECOLI iep swissprot:AROA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AROA_ECOLI inforesidue swissprot:AROA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AROA_ECOLI octanol swissprot:AROA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AROA_ECOLI pepcoil swissprot:AROA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AROA_ECOLI pepdigest swissprot:AROA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AROA_ECOLI pepinfo swissprot:AROA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AROA_ECOLI pepnet swissprot:AROA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AROA_ECOLI pepstats swissprot:AROA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AROA_ECOLI pepwheel swissprot:AROA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AROA_ECOLI pepwindow swissprot:AROA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AROA_ECOLI sigcleave swissprot:AROA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AROA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260778 8 # EcoGene EG11594 ybeF # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; ISS:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IBA:GO_Central. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # IntAct P30979 2 # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR005119 LysR_subst-bd # InterPro IPR011991 WHTH_DNA-bd_dom # Organism YBEF_ECOLI Escherichia coli (strain K12) # PATRIC 32116439 VBIEscCol129921_0659 # PIR C64797 C64797 # PROSITE PS50931 HTH_LYSR # Pfam PF00126 HTH_1 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBEF_ECOLI Uncharacterized HTH-type transcriptional regulator YbeF # RefSeq NP_415162 NC_000913.3 # RefSeq WP_000378026 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA66344.1; Type=Frameshift; Positions=53, 99; Evidence={ECO 0000305}; # SIMILARITY Contains 1 HTH lysR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00253}. # SUPFAM SSF46785 SSF46785 # eggNOG ENOG41064T2 Bacteria # eggNOG ENOG4110BBF LUCA BLAST swissprot:YBEF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBEF_ECOLI BioCyc ECOL316407:JW0624-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0624-MONOMER BioCyc EcoCyc:EG11594-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11594-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L07636 http://www.ebi.ac.uk/ena/data/view/L07636 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB1551 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1551 EcoGene EG11594 http://www.ecogene.org/geneInfo.php?eg_id=EG11594 EnsemblBacteria AAC73730 http://www.ensemblgenomes.org/id/AAC73730 EnsemblBacteria AAC73730 http://www.ensemblgenomes.org/id/AAC73730 EnsemblBacteria BAA35272 http://www.ensemblgenomes.org/id/BAA35272 EnsemblBacteria BAA35272 http://www.ensemblgenomes.org/id/BAA35272 EnsemblBacteria BAA35272 http://www.ensemblgenomes.org/id/BAA35272 EnsemblBacteria b0629 http://www.ensemblgenomes.org/id/b0629 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 945219 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945219 HOGENOM HOG000267879 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267879&db=HOGENOM6 IntAct P30979 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P30979* InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW0624 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0624 KEGG_Gene eco:b0629 http://www.genome.jp/dbget-bin/www_bget?eco:b0629 OMA RMTWNES http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RMTWNES PROSITE PS50931 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50931 PSORT swissprot:YBEF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBEF_ECOLI PSORT-B swissprot:YBEF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBEF_ECOLI PSORT2 swissprot:YBEF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBEF_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:YBEF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBEF_ECOLI PhylomeDB P30979 http://phylomedb.org/?seqid=P30979 ProteinModelPortal P30979 http://www.proteinmodelportal.org/query/uniprot/P30979 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8444795 http://www.ncbi.nlm.nih.gov/pubmed/8444795 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415162 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415162 RefSeq WP_000378026 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000378026 SMR P30979 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P30979 STRING 511145.b0629 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0629&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB YBEF_ECOLI http://www.uniprot.org/uniprot/YBEF_ECOLI UniProtKB-AC P30979 http://www.uniprot.org/uniprot/P30979 charge swissprot:YBEF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBEF_ECOLI eggNOG ENOG41064T2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41064T2 eggNOG ENOG4110BBF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4110BBF epestfind swissprot:YBEF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBEF_ECOLI garnier swissprot:YBEF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBEF_ECOLI helixturnhelix swissprot:YBEF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBEF_ECOLI hmoment swissprot:YBEF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBEF_ECOLI iep swissprot:YBEF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBEF_ECOLI inforesidue swissprot:YBEF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBEF_ECOLI octanol swissprot:YBEF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBEF_ECOLI pepcoil swissprot:YBEF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBEF_ECOLI pepdigest swissprot:YBEF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBEF_ECOLI pepinfo swissprot:YBEF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBEF_ECOLI pepnet swissprot:YBEF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBEF_ECOLI pepstats swissprot:YBEF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBEF_ECOLI pepwheel swissprot:YBEF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBEF_ECOLI pepwindow swissprot:YBEF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBEF_ECOLI sigcleave swissprot:YBEF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBEF_ECOLI ## Database ID URL or Descriptions # BioGrid 4259676 168 # CAZy GT4 Glycosyltransferase Family 4 # EcoGene EG12652 wcaL # GO_function GO:0016757 transferase activity, transferring glycosyl groups; IEA:UniProtKB-KW. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0045228 slime layer polysaccharide biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # InterPro IPR001296 Glyco_trans_1 # InterPro IPR023884 Colanic_acid_synth_WcaL # InterPro IPR028098 Glyco_trans_4-like_N # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01003 Glycosyltransferases # Organism WCAL_ECOLI Escherichia coli (strain K12) # PATHWAY WCAL_ECOLI Slime biogenesis; slime polysaccharide biosynthesis. # PATRIC 32119421 VBIEscCol129921_2121 # PIR C64970 C64970 # Pfam PF00534 Glycos_transf_1 # Pfam PF13439 Glyco_transf_4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName WCAL_ECOLI Putative colanic acid biosynthesis glycosyltransferase WcaL # RefSeq NP_416548 NC_000913.3 # RefSeq WP_000862592 NZ_LN832404.1 # SIMILARITY Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. {ECO 0000305}. # TIGRFAMs TIGR04005 wcaL # eggNOG COG0438 LUCA # eggNOG ENOG4107T8Q Bacteria BLAST swissprot:WCAL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:WCAL_ECOLI BioCyc ECOL316407:JW2029-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2029-MONOMER BioCyc EcoCyc:G7095-MONOMER http://biocyc.org/getid?id=EcoCyc:G7095-MONOMER COG CAZy: http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=CAZy: COG COG0438 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0438 COG GT4 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=GT4 DIP DIP-11127N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11127N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.4.-.- http://www.genome.jp/dbget-bin/www_bget?EC:2.4.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U38473 http://www.ebi.ac.uk/ena/data/view/U38473 ENZYME 2.4.-.- http://enzyme.expasy.org/EC/2.4.-.- EchoBASE EB2522 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2522 EcoGene EG12652 http://www.ecogene.org/geneInfo.php?eg_id=EG12652 EnsemblBacteria AAC75105 http://www.ensemblgenomes.org/id/AAC75105 EnsemblBacteria AAC75105 http://www.ensemblgenomes.org/id/AAC75105 EnsemblBacteria BAA15898 http://www.ensemblgenomes.org/id/BAA15898 EnsemblBacteria BAA15898 http://www.ensemblgenomes.org/id/BAA15898 EnsemblBacteria BAA15898 http://www.ensemblgenomes.org/id/BAA15898 EnsemblBacteria b2044 http://www.ensemblgenomes.org/id/b2044 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GO_process GO:0045228 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045228 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 946565 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946565 HOGENOM HOG000121940 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000121940&db=HOGENOM6 InParanoid P71243 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P71243 IntAct P71243 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P71243* IntEnz 2.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4 InterPro IPR001296 http://www.ebi.ac.uk/interpro/entry/IPR001296 InterPro IPR023884 http://www.ebi.ac.uk/interpro/entry/IPR023884 InterPro IPR028098 http://www.ebi.ac.uk/interpro/entry/IPR028098 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01003 http://www.genome.jp/dbget-bin/www_bget?ko01003 KEGG_Gene ecj:JW2029 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2029 KEGG_Gene eco:b2044 http://www.genome.jp/dbget-bin/www_bget?eco:b2044 KEGG_Orthology KO:K16703 http://www.genome.jp/dbget-bin/www_bget?KO:K16703 MINT MINT-1263848 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1263848 OMA YGDEARN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YGDEARN PSORT swissprot:WCAL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:WCAL_ECOLI PSORT-B swissprot:WCAL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:WCAL_ECOLI PSORT2 swissprot:WCAL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:WCAL_ECOLI Pfam PF00534 http://pfam.xfam.org/family/PF00534 Pfam PF13439 http://pfam.xfam.org/family/PF13439 Phobius swissprot:WCAL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:WCAL_ECOLI PhylomeDB P71243 http://phylomedb.org/?seqid=P71243 ProteinModelPortal P71243 http://www.proteinmodelportal.org/query/uniprot/P71243 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8759852 http://www.ncbi.nlm.nih.gov/pubmed/8759852 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416548 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416548 RefSeq WP_000862592 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000862592 SMR P71243 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P71243 STRING 511145.b2044 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2044&targetmode=cogs STRING CAZy: http://string-db.org/newstring_cgi/show_network_section.pl?identifier=CAZy:&targetmode=cogs STRING COG0438 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0438&targetmode=cogs STRING GT4 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=GT4&targetmode=cogs TIGRFAMs TIGR04005 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR04005 UniProtKB WCAL_ECOLI http://www.uniprot.org/uniprot/WCAL_ECOLI UniProtKB-AC P71243 http://www.uniprot.org/uniprot/P71243 charge swissprot:WCAL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:WCAL_ECOLI eggNOG COG0438 http://eggnogapi.embl.de/nog_data/html/tree/COG0438 eggNOG ENOG4107T8Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107T8Q epestfind swissprot:WCAL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:WCAL_ECOLI garnier swissprot:WCAL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:WCAL_ECOLI helixturnhelix swissprot:WCAL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:WCAL_ECOLI hmoment swissprot:WCAL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:WCAL_ECOLI iep swissprot:WCAL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:WCAL_ECOLI inforesidue swissprot:WCAL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:WCAL_ECOLI octanol swissprot:WCAL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:WCAL_ECOLI pepcoil swissprot:WCAL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:WCAL_ECOLI pepdigest swissprot:WCAL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:WCAL_ECOLI pepinfo swissprot:WCAL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:WCAL_ECOLI pepnet swissprot:WCAL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:WCAL_ECOLI pepstats swissprot:WCAL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:WCAL_ECOLI pepwheel swissprot:WCAL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:WCAL_ECOLI pepwindow swissprot:WCAL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:WCAL_ECOLI sigcleave swissprot:WCAL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:WCAL_ECOLI ## Database ID URL or Descriptions # BioGrid 4261973 10 # EcoGene EG11950 nrfG # FUNCTION NRFG_ECOLI Required for formate-dependent nitrite reduction. Not required for the biosynthesis of any of the c-type cytochromes nor for the secretion of the periplasmic cytochromes. # GO_process GO:0018378 cytochrome c-heme linkage via heme-L-cysteine; IMP:EcoCyc. # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0006464 cellular protein modification process # Gene3D 1.25.40.10 -; 2. # IntAct P32712 5 # InterPro IPR011990 TPR-like_helical_dom # InterPro IPR013026 TPR-contain_dom # InterPro IPR019734 TPR_repeat # Organism NRFG_ECOLI Escherichia coli (strain K12) # PATRIC 32123701 VBIEscCol129921_4199 # PIR A57987 A57987 # PROSITE PS50005 TPR; 2 # PROSITE PS50293 TPR_REGION # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NRFG_ECOLI Formate-dependent nitrite reductase complex subunit NrfG # RefSeq NP_418500 NC_000913.3 # RefSeq WP_000812896 NZ_LN832404.1 # SIMILARITY Contains 2 TPR repeats. {ECO:0000255|PROSITE- ProRule PRU00339}. # SMART SM00028 TPR; 2 # SUPFAM SSF48452 SSF48452 # eggNOG COG4235 LUCA # eggNOG ENOG4108W0S Bacteria BLAST swissprot:NRFG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NRFG_ECOLI BioCyc ECOL316407:JW4037-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4037-MONOMER BioCyc EcoCyc:EG11950-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11950-MONOMER COG COG0457 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0457 DOI 10.1007/BF02173779 http://dx.doi.org/10.1007/BF02173779 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1111/j.1365-2958.1994.tb01004.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb01004.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X72298 http://www.ebi.ac.uk/ena/data/view/X72298 EchoBASE EB1893 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1893 EcoGene EG11950 http://www.ecogene.org/geneInfo.php?eg_id=EG11950 EnsemblBacteria AAD13459 http://www.ensemblgenomes.org/id/AAD13459 EnsemblBacteria AAD13459 http://www.ensemblgenomes.org/id/AAD13459 EnsemblBacteria BAE78078 http://www.ensemblgenomes.org/id/BAE78078 EnsemblBacteria BAE78078 http://www.ensemblgenomes.org/id/BAE78078 EnsemblBacteria BAE78078 http://www.ensemblgenomes.org/id/BAE78078 EnsemblBacteria b4076 http://www.ensemblgenomes.org/id/b4076 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0018378 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018378 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 Gene3D 1.25.40.10 http://www.cathdb.info/version/latest/superfamily/1.25.40.10 GeneID 948592 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948592 HOGENOM HOG000126931 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126931&db=HOGENOM6 InParanoid P32712 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32712 IntAct P32712 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32712* InterPro IPR011990 http://www.ebi.ac.uk/interpro/entry/IPR011990 InterPro IPR013026 http://www.ebi.ac.uk/interpro/entry/IPR013026 InterPro IPR019734 http://www.ebi.ac.uk/interpro/entry/IPR019734 KEGG_Gene ecj:JW4037 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4037 KEGG_Gene eco:b4076 http://www.genome.jp/dbget-bin/www_bget?eco:b4076 KEGG_Orthology KO:K04018 http://www.genome.jp/dbget-bin/www_bget?KO:K04018 OMA VQARAMI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VQARAMI PROSITE PS50005 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50005 PROSITE PS50293 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50293 PSORT swissprot:NRFG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NRFG_ECOLI PSORT-B swissprot:NRFG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NRFG_ECOLI PSORT2 swissprot:NRFG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NRFG_ECOLI Phobius swissprot:NRFG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NRFG_ECOLI PhylomeDB P32712 http://phylomedb.org/?seqid=P32712 ProteinModelPortal P32712 http://www.proteinmodelportal.org/query/uniprot/P32712 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8057835 http://www.ncbi.nlm.nih.gov/pubmed/8057835 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 8842153 http://www.ncbi.nlm.nih.gov/pubmed/8842153 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418500 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418500 RefSeq WP_000812896 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000812896 SMART SM00028 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00028 SMR P32712 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32712 STRING 511145.b4076 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4076&targetmode=cogs STRING COG0457 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0457&targetmode=cogs SUPFAM SSF48452 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48452 UniProtKB NRFG_ECOLI http://www.uniprot.org/uniprot/NRFG_ECOLI UniProtKB-AC P32712 http://www.uniprot.org/uniprot/P32712 charge swissprot:NRFG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NRFG_ECOLI eggNOG COG4235 http://eggnogapi.embl.de/nog_data/html/tree/COG4235 eggNOG ENOG4108W0S http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108W0S epestfind swissprot:NRFG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NRFG_ECOLI garnier swissprot:NRFG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NRFG_ECOLI helixturnhelix swissprot:NRFG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NRFG_ECOLI hmoment swissprot:NRFG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NRFG_ECOLI iep swissprot:NRFG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NRFG_ECOLI inforesidue swissprot:NRFG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NRFG_ECOLI octanol swissprot:NRFG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NRFG_ECOLI pepcoil swissprot:NRFG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NRFG_ECOLI pepdigest swissprot:NRFG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NRFG_ECOLI pepinfo swissprot:NRFG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NRFG_ECOLI pepnet swissprot:NRFG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NRFG_ECOLI pepstats swissprot:NRFG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NRFG_ECOLI pepwheel swissprot:NRFG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NRFG_ECOLI pepwindow swissprot:NRFG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NRFG_ECOLI sigcleave swissprot:NRFG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NRFG_ECOLI ## Database ID URL or Descriptions # GO_function GO:0008270 zinc ion binding; IEA:InterPro. # GOslim_function GO:0043167 ion binding # InterPro IPR000962 Znf_DskA_TraR # InterPro IPR012783 Znf_C4_TraR # InterPro IPR020458 Znf_DskA_TraR_CS # InterPro IPR020460 Znf_C4-type_bac # Organism TRAR_ECOLI Escherichia coli (strain K12) # PIR PQ0135 PQ0135 # PRINTS PR00618 DKSAZNFINGER # PROSITE PS01102 ZF_DKSA_1 # PROSITE PS51128 ZF_DKSA_2 # Pfam PF01258 zf-dskA_traR # RecName TRAR_ECOLI Protein TraR # RefSeq NP_061462 NC_002483.1 # RefSeq NP_862928 NC_004998.1 # RefSeq WP_001278689 NC_002483.1 # RefSeq YP_001965439 NC_010862.1 # RefSeq YP_003829015 NC_014382.1 # RefSeq YP_003937627 NC_014615.1 # RefSeq YP_008997949 NC_023315.1 # RefSeq YP_009060148 NC_024956.1 # RefSeq YP_009068342 NC_025139.1 # RefSeq YP_009070607 NC_025175.1 # RefSeq YP_009070976 NC_025177.1 # RefSeq YP_009071239 NC_025179.1 # SIMILARITY Contains 1 dksA C4-type zinc finger. {ECO:0000255|PROSITE-ProRule PRU00510}. # TIGRFAMs TIGR02419 C4_traR_proteo BLAST swissprot:TRAR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRAR_ECOLI DOI 10.1016/0378-1119(90)90354-T http://dx.doi.org/10.1016/0378-1119(90)90354-T EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL M30936 http://www.ebi.ac.uk/ena/data/view/M30936 EMBL U01159 http://www.ebi.ac.uk/ena/data/view/U01159 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GeneID 1263563 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263563 GeneID 1446492 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1446492 GeneID 18194775 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18194775 GeneID 20467918 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20467918 GeneID 20491472 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20491472 GeneID 20492675 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20492675 GeneID 20493046 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20493046 GeneID 20493311 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20493311 GeneID 6382235 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6382235 GeneID 9537880 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9537880 GeneID 9846163 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9846163 InterPro IPR000962 http://www.ebi.ac.uk/interpro/entry/IPR000962 InterPro IPR012783 http://www.ebi.ac.uk/interpro/entry/IPR012783 InterPro IPR020458 http://www.ebi.ac.uk/interpro/entry/IPR020458 InterPro IPR020460 http://www.ebi.ac.uk/interpro/entry/IPR020460 OMA EMAMATT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EMAMATT PRINTS PR00618 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00618 PROSITE PS01102 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01102 PROSITE PS51128 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51128 PSORT swissprot:TRAR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRAR_ECOLI PSORT-B swissprot:TRAR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRAR_ECOLI PSORT2 swissprot:TRAR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRAR_ECOLI Pfam PF01258 http://pfam.xfam.org/family/PF01258 Phobius swissprot:TRAR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRAR_ECOLI PhylomeDB P41065 http://phylomedb.org/?seqid=P41065 ProteinModelPortal P41065 http://www.proteinmodelportal.org/query/uniprot/P41065 PubMed 2265751 http://www.ncbi.nlm.nih.gov/pubmed/2265751 PubMed 7915817 http://www.ncbi.nlm.nih.gov/pubmed/7915817 PubMed 8021201 http://www.ncbi.nlm.nih.gov/pubmed/8021201 RefSeq NP_061462 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061462 RefSeq NP_862928 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_862928 RefSeq WP_001278689 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001278689 RefSeq YP_001965439 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001965439 RefSeq YP_003829015 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_003829015 RefSeq YP_003937627 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_003937627 RefSeq YP_008997949 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_008997949 RefSeq YP_009060148 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009060148 RefSeq YP_009068342 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009068342 RefSeq YP_009070607 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009070607 RefSeq YP_009070976 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009070976 RefSeq YP_009071239 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009071239 SMR P41065 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P41065 TIGRFAMs TIGR02419 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02419 UniProtKB TRAR_ECOLI http://www.uniprot.org/uniprot/TRAR_ECOLI UniProtKB-AC P41065 http://www.uniprot.org/uniprot/P41065 charge swissprot:TRAR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRAR_ECOLI epestfind swissprot:TRAR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRAR_ECOLI garnier swissprot:TRAR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRAR_ECOLI helixturnhelix swissprot:TRAR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRAR_ECOLI hmoment swissprot:TRAR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRAR_ECOLI iep swissprot:TRAR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRAR_ECOLI inforesidue swissprot:TRAR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRAR_ECOLI octanol swissprot:TRAR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRAR_ECOLI pepcoil swissprot:TRAR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRAR_ECOLI pepdigest swissprot:TRAR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRAR_ECOLI pepinfo swissprot:TRAR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRAR_ECOLI pepnet swissprot:TRAR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRAR_ECOLI pepstats swissprot:TRAR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRAR_ECOLI pepwheel swissprot:TRAR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRAR_ECOLI pepwindow swissprot:TRAR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRAR_ECOLI sigcleave swissprot:TRAR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRAR_ECOLI ## Database ID URL or Descriptions # AltName RSMB_ECOLI 16S rRNA m5C967 methyltransferase # AltName RSMB_ECOLI rRNA (cytosine-C(5)-)-methyltransferase RsmB # BRENDA 2.1.1.176 2026 # BioGrid 4263436 10 # CATALYTIC ACTIVITY RSMB_ECOLI S-adenosyl-L-methionine + cytosine(967) in 16S rRNA = S-adenosyl-L-homocysteine + 5-methylcytosine(967) in 16S rRNA. # EcoGene EG12163 rsmB # FUNCTION RSMB_ECOLI Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. {ECO 0000269|PubMed 10194318}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003723 RNA binding; IEA:UniProtKB-KW. # GO_function GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity; IDA:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:InterPro. # GO_process GO:0070475 rRNA base methylation; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.940.10 -; 1. # Gene3D 3.40.50.150 -; 1. # HAMAP MF_01856 16SrRNA_methyltr_B # IntAct P36929 14 # InterPro IPR001678 MeTrfase_RsmB/NOP2 # InterPro IPR004573 rRNA_ssu_MeTfrase_B # InterPro IPR006027 NusB_RsmB_TIM44 # InterPro IPR018314 Fmu/NOL1/Nop2p_CS # InterPro IPR023267 RCMT # InterPro IPR023541 rRNA_ssu_MeTfrase_B_ent # InterPro IPR029063 SAM-dependent_MTases # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # Organism RSMB_ECOLI Escherichia coli (strain K12) # PATRIC 32122010 VBIEscCol129921_3382 # PDB 1J4F Model; -; A=228-429 # PDB 1SQF X-ray; 2.10 A; A=1-429 # PDB 1SQG X-ray; 1.65 A; A=1-429 # PIR D65121 D65121 # PRINTS PR02008 RCMTFAMILY # PROSITE PS01153 NOL1_NOP2_SUN # PROSITE PS51686 SAM_MT_RSMB_NOP # Pfam PF01029 NusB # Pfam PF01189 Methyltr_RsmB-F # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RSMB_ECOLI Ribosomal RNA small subunit methyltransferase B # RefSeq NP_417747 NC_000913.3 # RefSeq WP_000744778 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA58086.1; Type=Frameshift; Positions=384; Evidence={ECO:0000305}; Sequence=CAA54369.1; Type=Frameshift; Positions=201; Note=Was originally named Fmu and represented the N-terminal part of the RsmB protein.; Evidence={ECO 0000305}; Sequence=CAA54370.1; Type=Frameshift; Positions=201; Note=Was originally named Fmv and represented the C-terminal part of the RsmB protein.; Evidence={ECO:0000305}; # SIMILARITY Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. {ECO 0000305}. # SUBCELLULAR LOCATION RSMB_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF48013 SSF48013 # SUPFAM SSF53335 SSF53335 # TIGRFAMs TIGR00563 rsmB # eggNOG COG0144 LUCA # eggNOG ENOG4105CYJ Bacteria BLAST swissprot:RSMB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RSMB_ECOLI BioCyc ECOL316407:JW3250-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3250-MONOMER BioCyc EcoCyc:EG12163-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12163-MONOMER BioCyc MetaCyc:EG12163-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12163-MONOMER COG COG0144 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0144 DIP DIP-10946N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10946N DOI 10.1006/jmbi.1996.0835 http://dx.doi.org/10.1006/jmbi.1996.0835 DOI 10.1016/j.str.2003.10.014 http://dx.doi.org/10.1016/j.str.2003.10.014 DOI 10.1021/bi981880l http://dx.doi.org/10.1021/bi981880l DOI 10.1021/bi982364y http://dx.doi.org/10.1021/bi982364y DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.97.15.8263 http://dx.doi.org/10.1073/pnas.97.15.8263 DOI 10.1111/j.1365-2958.1993.tb01714.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb01714.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.1.176 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.176 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X52114 http://www.ebi.ac.uk/ena/data/view/X52114 EMBL X77091 http://www.ebi.ac.uk/ena/data/view/X77091 EMBL X77091 http://www.ebi.ac.uk/ena/data/view/X77091 EMBL Y10307 http://www.ebi.ac.uk/ena/data/view/Y10307 ENZYME 2.1.1.176 http://enzyme.expasy.org/EC/2.1.1.176 EchoBASE EB2082 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2082 EcoGene EG12163 http://www.ecogene.org/geneInfo.php?eg_id=EG12163 EnsemblBacteria AAC76314 http://www.ensemblgenomes.org/id/AAC76314 EnsemblBacteria AAC76314 http://www.ensemblgenomes.org/id/AAC76314 EnsemblBacteria BAE78003 http://www.ensemblgenomes.org/id/BAE78003 EnsemblBacteria BAE78003 http://www.ensemblgenomes.org/id/BAE78003 EnsemblBacteria BAE78003 http://www.ensemblgenomes.org/id/BAE78003 EnsemblBacteria b3289 http://www.ensemblgenomes.org/id/b3289 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0009383 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009383 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0070475 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070475 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.940.10 http://www.cathdb.info/version/latest/superfamily/1.10.940.10 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 GeneID 947789 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947789 HAMAP MF_01856 http://hamap.expasy.org/unirule/MF_01856 HOGENOM HOG000037300 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000037300&db=HOGENOM6 InParanoid P36929 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P36929 IntAct P36929 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P36929* IntEnz 2.1.1.176 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.176 InterPro IPR001678 http://www.ebi.ac.uk/interpro/entry/IPR001678 InterPro IPR004573 http://www.ebi.ac.uk/interpro/entry/IPR004573 InterPro IPR006027 http://www.ebi.ac.uk/interpro/entry/IPR006027 InterPro IPR018314 http://www.ebi.ac.uk/interpro/entry/IPR018314 InterPro IPR023267 http://www.ebi.ac.uk/interpro/entry/IPR023267 InterPro IPR023541 http://www.ebi.ac.uk/interpro/entry/IPR023541 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW3250 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3250 KEGG_Gene eco:b3289 http://www.genome.jp/dbget-bin/www_bget?eco:b3289 KEGG_Orthology KO:K03500 http://www.genome.jp/dbget-bin/www_bget?KO:K03500 OMA LRVNRQH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LRVNRQH PDB 1J4F http://www.ebi.ac.uk/pdbe-srv/view/entry/1J4F PDB 1SQF http://www.ebi.ac.uk/pdbe-srv/view/entry/1SQF PDB 1SQG http://www.ebi.ac.uk/pdbe-srv/view/entry/1SQG PDBsum 1J4F http://www.ebi.ac.uk/pdbsum/1J4F PDBsum 1SQF http://www.ebi.ac.uk/pdbsum/1SQF PDBsum 1SQG http://www.ebi.ac.uk/pdbsum/1SQG PRINTS PR02008 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR02008 PROSITE PS01153 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01153 PROSITE PS51686 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51686 PSORT swissprot:RSMB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RSMB_ECOLI PSORT-B swissprot:RSMB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RSMB_ECOLI PSORT2 swissprot:RSMB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RSMB_ECOLI Pfam PF01029 http://pfam.xfam.org/family/PF01029 Pfam PF01189 http://pfam.xfam.org/family/PF01189 Phobius swissprot:RSMB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RSMB_ECOLI PhylomeDB P36929 http://phylomedb.org/?seqid=P36929 ProteinModelPortal P36929 http://www.proteinmodelportal.org/query/uniprot/P36929 PubMed 10026269 http://www.ncbi.nlm.nih.gov/pubmed/10026269 PubMed 10194318 http://www.ncbi.nlm.nih.gov/pubmed/10194318 PubMed 10899996 http://www.ncbi.nlm.nih.gov/pubmed/10899996 PubMed 14656444 http://www.ncbi.nlm.nih.gov/pubmed/14656444 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8412700 http://www.ncbi.nlm.nih.gov/pubmed/8412700 PubMed 8432722 http://www.ncbi.nlm.nih.gov/pubmed/8432722 PubMed 9086272 http://www.ncbi.nlm.nih.gov/pubmed/9086272 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417747 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417747 RefSeq WP_000744778 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000744778 SMR P36929 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P36929 STRING 511145.b3289 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3289&targetmode=cogs STRING COG0144 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0144&targetmode=cogs SUPFAM SSF48013 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48013 SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 TIGRFAMs TIGR00563 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00563 UniProtKB RSMB_ECOLI http://www.uniprot.org/uniprot/RSMB_ECOLI UniProtKB-AC P36929 http://www.uniprot.org/uniprot/P36929 charge swissprot:RSMB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RSMB_ECOLI eggNOG COG0144 http://eggnogapi.embl.de/nog_data/html/tree/COG0144 eggNOG ENOG4105CYJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CYJ epestfind swissprot:RSMB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RSMB_ECOLI garnier swissprot:RSMB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RSMB_ECOLI helixturnhelix swissprot:RSMB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RSMB_ECOLI hmoment swissprot:RSMB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RSMB_ECOLI iep swissprot:RSMB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RSMB_ECOLI inforesidue swissprot:RSMB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RSMB_ECOLI octanol swissprot:RSMB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RSMB_ECOLI pepcoil swissprot:RSMB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RSMB_ECOLI pepdigest swissprot:RSMB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RSMB_ECOLI pepinfo swissprot:RSMB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RSMB_ECOLI pepnet swissprot:RSMB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RSMB_ECOLI pepstats swissprot:RSMB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RSMB_ECOLI pepwheel swissprot:RSMB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RSMB_ECOLI pepwindow swissprot:RSMB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RSMB_ECOLI sigcleave swissprot:RSMB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RSMB_ECOLI ## Database ID URL or Descriptions # AltName DNA-invertase PinE {ECO 0000305} # AltName Site-specific recombinase PinE {ECO 0000305} # BioGrid 4262859 142 # EcoGene EG10737 pinE # FUNCTION PINE_ECOLI This protein catalyzes the inversion of an 1800-bp E.coli DNA fragment, the P region, which can exist in either orientation. The function of the inversion is not yet clear. # GO_function GO:0000150 recombinase activity; IMP:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0016787 hydrolase activity; IEA:UniProtKB-KW. # GO_function GO:0016874 ligase activity; IEA:UniProtKB-KW. # GO_process GO:0006310 DNA recombination; IMP:EcoCyc. # GO_process GO:0015074 DNA integration; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016874 ligase activity # GOslim_process GO:0006259 DNA metabolic process # Gene3D 1.10.10.60 -; 1. # Gene3D 3.40.50.1390 -; 1. # IntAct P03014 2 # InterPro IPR006118 Recombinase_CS # InterPro IPR006119 Resolv_N # InterPro IPR006120 Resolvase_HTH_dom # InterPro IPR009057 Homeodomain-like # Organism PINE_ECOLI Escherichia coli (strain K12) # PATRIC 32117553 VBIEscCol129921_1199 # PIR A03545 JWEC # PROSITE PS00397 RECOMBINASES_1 # PROSITE PS00398 RECOMBINASES_2 # PROSITE PS51736 RECOMBINASES_3 # Pfam PF00239 Resolvase # Pfam PF02796 HTH_7 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Serine recombinase PinE {ECO:0000250|UniProtKB P03015} # RefSeq NP_415676 NC_000913.3 # RefSeq WP_000905001 NZ_CP010440.1 # SIMILARITY Belongs to the site-specific recombinase resolvase family. {ECO 0000305}. # SIMILARITY Contains 1 resolvase/invertase-type recombinase catalytic domain. {ECO:0000255|PROSITE-ProRule PRU01072}. # SMART SM00857 Resolvase # SUPFAM SSF46689 SSF46689 # SUPFAM SSF53041 SSF53041 # eggNOG COG1961 LUCA # eggNOG ENOG4108C33 Bacteria BLAST swissprot:PINE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PINE_ECOLI BioCyc ECOL316407:JW1144-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1144-MONOMER BioCyc EcoCyc:EG10737-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10737-MONOMER BioCyc MetaCyc:EG10737-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10737-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.80.17.5355 http://dx.doi.org/10.1073/pnas.80.17.5355 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.22.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.22.- EC_number EC:6.5.1.- http://www.genome.jp/dbget-bin/www_bget?EC:6.5.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K00676 http://www.ebi.ac.uk/ena/data/view/K00676 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X01805 http://www.ebi.ac.uk/ena/data/view/X01805 ENZYME 3.1.22.- http://enzyme.expasy.org/EC/3.1.22.- ENZYME 6.5.1.- http://enzyme.expasy.org/EC/6.5.1.- EchoBASE EB0730 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0730 EcoGene EG10737 http://www.ecogene.org/geneInfo.php?eg_id=EG10737 EnsemblBacteria AAC74242 http://www.ensemblgenomes.org/id/AAC74242 EnsemblBacteria AAC74242 http://www.ensemblgenomes.org/id/AAC74242 EnsemblBacteria BAA35994 http://www.ensemblgenomes.org/id/BAA35994 EnsemblBacteria BAA35994 http://www.ensemblgenomes.org/id/BAA35994 EnsemblBacteria BAA35994 http://www.ensemblgenomes.org/id/BAA35994 EnsemblBacteria b1158 http://www.ensemblgenomes.org/id/b1158 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000150 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0016787 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016787 GO_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0015074 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015074 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 Gene3D 3.40.50.1390 http://www.cathdb.info/version/latest/superfamily/3.40.50.1390 GeneID 945721 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945721 HOGENOM HOG000275578 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275578&db=HOGENOM6 InParanoid P03014 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P03014 IntAct P03014 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P03014* IntEnz 3.1.22 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.22 IntEnz 6.5.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.5.1 InterPro IPR006118 http://www.ebi.ac.uk/interpro/entry/IPR006118 InterPro IPR006119 http://www.ebi.ac.uk/interpro/entry/IPR006119 InterPro IPR006120 http://www.ebi.ac.uk/interpro/entry/IPR006120 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 KEGG_Gene ecj:JW1144 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1144 KEGG_Gene eco:b1158 http://www.genome.jp/dbget-bin/www_bget?eco:b1158 OMA RWQIANI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RWQIANI PROSITE PS00397 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00397 PROSITE PS00398 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00398 PROSITE PS51736 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51736 PSORT swissprot:PINE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PINE_ECOLI PSORT-B swissprot:PINE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PINE_ECOLI PSORT2 swissprot:PINE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PINE_ECOLI Pfam PF00239 http://pfam.xfam.org/family/PF00239 Pfam PF02796 http://pfam.xfam.org/family/PF02796 Phobius swissprot:PINE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PINE_ECOLI PhylomeDB P03014 http://phylomedb.org/?seqid=P03014 ProteinModelPortal P03014 http://www.proteinmodelportal.org/query/uniprot/P03014 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3894006 http://www.ncbi.nlm.nih.gov/pubmed/3894006 PubMed 6310572 http://www.ncbi.nlm.nih.gov/pubmed/6310572 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415676 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415676 RefSeq WP_000905001 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000905001 SMART SM00857 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00857 SMR P03014 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P03014 STRING 511145.b1158 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1158&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF53041 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53041 UniProtKB PINE_ECOLI http://www.uniprot.org/uniprot/PINE_ECOLI UniProtKB-AC P03014 http://www.uniprot.org/uniprot/P03014 charge swissprot:PINE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PINE_ECOLI eggNOG COG1961 http://eggnogapi.embl.de/nog_data/html/tree/COG1961 eggNOG ENOG4108C33 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108C33 epestfind swissprot:PINE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PINE_ECOLI garnier swissprot:PINE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PINE_ECOLI helixturnhelix swissprot:PINE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PINE_ECOLI hmoment swissprot:PINE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PINE_ECOLI iep swissprot:PINE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PINE_ECOLI inforesidue swissprot:PINE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PINE_ECOLI octanol swissprot:PINE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PINE_ECOLI pepcoil swissprot:PINE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PINE_ECOLI pepdigest swissprot:PINE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PINE_ECOLI pepinfo swissprot:PINE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PINE_ECOLI pepnet swissprot:PINE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PINE_ECOLI pepstats swissprot:PINE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PINE_ECOLI pepwheel swissprot:PINE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PINE_ECOLI pepwindow swissprot:PINE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PINE_ECOLI sigcleave swissprot:PINE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PINE_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES GHXQ_ECOLI Kinetic parameters KM=1.8 uM for guanine {ECO 0000269|PubMed 24214977}; KM=23.2 uM for hypoxanthine {ECO 0000269|PubMed 24214977}; Vmax=3.4 nmol/min/mg enzyme with guanine as substrate {ECO 0000269|PubMed 24214977}; Vmax=13.8 nmol/min/mg enzyme with hypoxanthine as substrate {ECO 0000269|PubMed 24214977}; # BioGrid 4259228 164 # EcoGene EG13067 ghxQ # FUNCTION GHXQ_ECOLI High-affinity transporter for guanine and hypoxanthine. {ECO 0000269|PubMed 24214977}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015208 guanine transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0035344 hypoxanthine transport; IMP:EcoCyc. # GO_process GO:0061489 guanine import into cell; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR006043 Xant/urac/vitC # KEGG_Brite ko02000 Transporters # Organism GHXQ_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11119 PTHR11119 # PATRIC 32121178 VBIEscCol129921_2977 # PIR D65072 D65072 # PIR E65072 E65072 # Pfam PF00860 Xan_ur_permease # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GHXQ_ECOLI Guanine/hypoxanthine permease GhxQ # RefSeq WP_000012163 NZ_LN832404.1 # RefSeq YP_026186 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA83065.1; Type=Frameshift; Positions=179; Note=Produces two separate ORFs (ygfQ and ygfR).; Evidence={ECO:0000305}; Sequence=AAA83066.1; Type=Frameshift; Positions=179; Note=Produces two separate ORFs (ygfQ and ygfR).; Evidence={ECO 0000305}; # SIMILARITY Belongs to the xanthine/uracil permease family. AzgA purine transporter (TC 2.A.1.40) subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION GHXQ_ECOLI Cell membrane {ECO 0000269|PubMed 24214977}; Multi-pass membrane protein {ECO 0000269|PubMed 24214977}. # TCDB 2.A.40.7:the nucleobase/ascorbate transporter (nat) or nucleobase cation symporter-2 (ncs2) family # eggNOG COG2252 LUCA # eggNOG ENOG4105C7N Bacteria BLAST swissprot:GHXQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GHXQ_ECOLI BioCyc ECOL316407:JW5467-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5467-MONOMER BioCyc EcoCyc:G7504-MONOMER http://biocyc.org/getid?id=EcoCyc:G7504-MONOMER BioCyc MetaCyc:G7504-MONOMER http://biocyc.org/getid?id=MetaCyc:G7504-MONOMER COG COG2252 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2252 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M113.523340 http://dx.doi.org/10.1074/jbc.M113.523340 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 EchoBASE EB2879 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2879 EcoGene EG13067 http://www.ecogene.org/geneInfo.php?eg_id=EG13067 EnsemblBacteria AAT48153 http://www.ensemblgenomes.org/id/AAT48153 EnsemblBacteria AAT48153 http://www.ensemblgenomes.org/id/AAT48153 EnsemblBacteria BAE76950 http://www.ensemblgenomes.org/id/BAE76950 EnsemblBacteria BAE76950 http://www.ensemblgenomes.org/id/BAE76950 EnsemblBacteria BAE76950 http://www.ensemblgenomes.org/id/BAE76950 EnsemblBacteria b4464 http://www.ensemblgenomes.org/id/b4464 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015208 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015208 GO_process GO:0035344 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035344 GO_process GO:0061489 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061489 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 2847748 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2847748 HOGENOM HOG000244363 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000244363&db=HOGENOM6 InParanoid Q46817 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46817 InterPro IPR006043 http://www.ebi.ac.uk/interpro/entry/IPR006043 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5467 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5467 KEGG_Gene eco:b4464 http://www.genome.jp/dbget-bin/www_bget?eco:b4464 KEGG_Orthology KO:K06901 http://www.genome.jp/dbget-bin/www_bget?KO:K06901 OMA MCAVFIV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MCAVFIV PANTHER PTHR11119 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11119 PSORT swissprot:GHXQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GHXQ_ECOLI PSORT-B swissprot:GHXQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GHXQ_ECOLI PSORT2 swissprot:GHXQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GHXQ_ECOLI Pfam PF00860 http://pfam.xfam.org/family/PF00860 Phobius swissprot:GHXQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GHXQ_ECOLI PhylomeDB Q46817 http://phylomedb.org/?seqid=Q46817 ProteinModelPortal Q46817 http://www.proteinmodelportal.org/query/uniprot/Q46817 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 24214977 http://www.ncbi.nlm.nih.gov/pubmed/24214977 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000012163 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000012163 RefSeq YP_026186 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026186 STRING 511145.b4464 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4464&targetmode=cogs STRING COG2252 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2252&targetmode=cogs TCDB 2.A.40.7 http://www.tcdb.org/search/result.php?tc=2.A.40.7 UniProtKB GHXQ_ECOLI http://www.uniprot.org/uniprot/GHXQ_ECOLI UniProtKB-AC Q46817 http://www.uniprot.org/uniprot/Q46817 charge swissprot:GHXQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GHXQ_ECOLI eggNOG COG2252 http://eggnogapi.embl.de/nog_data/html/tree/COG2252 eggNOG ENOG4105C7N http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C7N epestfind swissprot:GHXQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GHXQ_ECOLI garnier swissprot:GHXQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GHXQ_ECOLI helixturnhelix swissprot:GHXQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GHXQ_ECOLI hmoment swissprot:GHXQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GHXQ_ECOLI iep swissprot:GHXQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GHXQ_ECOLI inforesidue swissprot:GHXQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GHXQ_ECOLI octanol swissprot:GHXQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GHXQ_ECOLI pepcoil swissprot:GHXQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GHXQ_ECOLI pepdigest swissprot:GHXQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GHXQ_ECOLI pepinfo swissprot:GHXQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GHXQ_ECOLI pepnet swissprot:GHXQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GHXQ_ECOLI pepstats swissprot:GHXQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GHXQ_ECOLI pepwheel swissprot:GHXQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GHXQ_ECOLI pepwindow swissprot:GHXQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GHXQ_ECOLI sigcleave swissprot:GHXQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GHXQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4259458 17 # COFACTOR YDIJ_ECOLI Name=FAD; Xref=ChEBI CHEBI 57692; Evidence={ECO 0000269|PubMed 25117543}; # COFACTOR YDIJ_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000269|PubMed 25117543}; # EcoGene EG13969 ydiJ # GO_function GO:0016614 oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0050660 flavin adenine dinucleotide binding; IEA:InterPro. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # Gene3D 3.30.43.10 -; 1. # Gene3D 3.30.465.10 -; 1. # IntAct P77748 2 # InterPro IPR004113 FAD-linked_oxidase_C # InterPro IPR006094 Oxid_FAD_bind_N # InterPro IPR009051 Helical_ferredxn # InterPro IPR016164 FAD-linked_Oxase-like_C # InterPro IPR016166 FAD-bd_2 # InterPro IPR016167 FAD-bd_2_sub1 # InterPro IPR016169 CO_DH_flavot_FAD-bd_sub2 # InterPro IPR017896 4Fe4S_Fe-S-bd # InterPro IPR017900 4Fe4S_Fe_S_CS # Organism YDIJ_ECOLI Escherichia coli (strain K12) # PATRIC 32118680 VBIEscCol129921_1758 # PIR G64926 G64926 # PROSITE PS00198 4FE4S_FER_1 # PROSITE PS51379 4FE4S_FER_2 # PROSITE PS51387 FAD_PCMH # Pfam PF01565 FAD_binding_4 # Pfam PF02913 FAD-oxidase_C # Pfam PF13183 Fer4_8 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Uncharacterized protein YdiJ {ECO 0000305} # RefSeq NP_416202 NC_000913.3 # RefSeq WP_000613008 NZ_LN832404.1 # SIMILARITY Contains 1 4Fe-4S ferredoxin-type domain. {ECO:0000255|PROSITE-ProRule PRU00711}. # SIMILARITY Contains 1 FAD-binding PCMH-type domain. {ECO:0000255|PROSITE-ProRule PRU00718}. # SUPFAM SSF46548 SSF46548; 2 # SUPFAM SSF55103 SSF55103 # SUPFAM SSF56176 SSF56176 # eggNOG COG0247 LUCA # eggNOG COG0277 LUCA # eggNOG ENOG4105CQB Bacteria BLAST swissprot:YDIJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDIJ_ECOLI BioCyc ECOL316407:JW1677-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1677-MONOMER BioCyc EcoCyc:G6913-MONOMER http://biocyc.org/getid?id=EcoCyc:G6913-MONOMER COG COG1741 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1741 DIP DIP-11751N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11751N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1039/c4mt00156g http://dx.doi.org/10.1039/c4mt00156g DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3726 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3726 EcoGene EG13969 http://www.ecogene.org/geneInfo.php?eg_id=EG13969 EnsemblBacteria AAC74757 http://www.ensemblgenomes.org/id/AAC74757 EnsemblBacteria AAC74757 http://www.ensemblgenomes.org/id/AAC74757 EnsemblBacteria BAA15451 http://www.ensemblgenomes.org/id/BAA15451 EnsemblBacteria BAA15451 http://www.ensemblgenomes.org/id/BAA15451 EnsemblBacteria BAA15451 http://www.ensemblgenomes.org/id/BAA15451 EnsemblBacteria b1687 http://www.ensemblgenomes.org/id/b1687 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016614 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016614 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.30.43.10 http://www.cathdb.info/version/latest/superfamily/3.30.43.10 Gene3D 3.30.465.10 http://www.cathdb.info/version/latest/superfamily/3.30.465.10 GeneID 946189 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946189 HOGENOM HOG000243746 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000243746&db=HOGENOM6 InParanoid P77748 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77748 IntAct P77748 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77748* InterPro IPR004113 http://www.ebi.ac.uk/interpro/entry/IPR004113 InterPro IPR006094 http://www.ebi.ac.uk/interpro/entry/IPR006094 InterPro IPR009051 http://www.ebi.ac.uk/interpro/entry/IPR009051 InterPro IPR016164 http://www.ebi.ac.uk/interpro/entry/IPR016164 InterPro IPR016166 http://www.ebi.ac.uk/interpro/entry/IPR016166 InterPro IPR016167 http://www.ebi.ac.uk/interpro/entry/IPR016167 InterPro IPR016169 http://www.ebi.ac.uk/interpro/entry/IPR016169 InterPro IPR017896 http://www.ebi.ac.uk/interpro/entry/IPR017896 InterPro IPR017900 http://www.ebi.ac.uk/interpro/entry/IPR017900 KEGG_Gene ecj:JW1677 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1677 KEGG_Gene eco:b1687 http://www.genome.jp/dbget-bin/www_bget?eco:b1687 KEGG_Orthology KO:K06911 http://www.genome.jp/dbget-bin/www_bget?KO:K06911 OMA FKPNGKP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FKPNGKP PROSITE PS00198 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00198 PROSITE PS51379 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51379 PROSITE PS51387 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51387 PSORT swissprot:YDIJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDIJ_ECOLI PSORT-B swissprot:YDIJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDIJ_ECOLI PSORT2 swissprot:YDIJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDIJ_ECOLI Pfam PF01565 http://pfam.xfam.org/family/PF01565 Pfam PF02913 http://pfam.xfam.org/family/PF02913 Pfam PF13183 http://pfam.xfam.org/family/PF13183 Phobius swissprot:YDIJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDIJ_ECOLI PhylomeDB P77748 http://phylomedb.org/?seqid=P77748 ProteinModelPortal P77748 http://www.proteinmodelportal.org/query/uniprot/P77748 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 25117543 http://www.ncbi.nlm.nih.gov/pubmed/25117543 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416202 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416202 RefSeq WP_000613008 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000613008 SMR P77748 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77748 STRING 511145.b1687 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1687&targetmode=cogs STRING COG1741 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1741&targetmode=cogs SUPFAM SSF46548 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46548 SUPFAM SSF55103 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55103 SUPFAM SSF56176 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56176 UniProtKB YDIJ_ECOLI http://www.uniprot.org/uniprot/YDIJ_ECOLI UniProtKB-AC P77748 http://www.uniprot.org/uniprot/P77748 charge swissprot:YDIJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDIJ_ECOLI eggNOG COG0247 http://eggnogapi.embl.de/nog_data/html/tree/COG0247 eggNOG COG0277 http://eggnogapi.embl.de/nog_data/html/tree/COG0277 eggNOG ENOG4105CQB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CQB epestfind swissprot:YDIJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDIJ_ECOLI garnier swissprot:YDIJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDIJ_ECOLI helixturnhelix swissprot:YDIJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDIJ_ECOLI hmoment swissprot:YDIJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDIJ_ECOLI iep swissprot:YDIJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDIJ_ECOLI inforesidue swissprot:YDIJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDIJ_ECOLI octanol swissprot:YDIJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDIJ_ECOLI pepcoil swissprot:YDIJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDIJ_ECOLI pepdigest swissprot:YDIJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDIJ_ECOLI pepinfo swissprot:YDIJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDIJ_ECOLI pepnet swissprot:YDIJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDIJ_ECOLI pepstats swissprot:YDIJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDIJ_ECOLI pepwheel swissprot:YDIJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDIJ_ECOLI pepwindow swissprot:YDIJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDIJ_ECOLI sigcleave swissprot:YDIJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDIJ_ECOLI ## Database ID URL or Descriptions # BRENDA 2.7.13 2026 # BioGrid 4260928 8 # CATALYTIC ACTIVITY NARQ_ECOLI ATP + protein L-histidine = ADP + protein N- phospho-L-histidine. # CDD cd06225 HAMP # EcoGene EG11460 narQ # FUNCTION NARQ_ECOLI Acts as a sensor for nitrate/nitrite and transduces signal of nitrate/nitrite availability to the NarL/NarP proteins. NarQ probably activates NarL and NarP by phosphorylation. NarQ probably negatively regulates the NarL protein by dephosphorylation. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0000155 phosphorelay sensor kinase activity; IMP:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0000160 phosphorelay signal transduction system; IMP:EcoCyc. # GO_process GO:0042128 nitrate assimilation; IEA:UniProtKB-KW. # GO_process GO:0071249 cellular response to nitrate; IMP:EcoCyc. # GO_process GO:0071250 cellular response to nitrite; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005622 intracellular # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0071941 nitrogen cycle metabolic process # Gene3D 3.30.565.10 -; 1. # IntAct P27896 12 # InterPro IPR003594 HATPase_C # InterPro IPR003660 HAMP_dom # InterPro IPR005467 His_kinase_dom # InterPro IPR011712 Sig_transdc_His_kin_sub3_dim/P # InterPro IPR029095 NarX-like_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01001 Protein kinases # KEGG_Brite ko02022 M00472 NarQ-NarP (nitrate respiration) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # Organism NARQ_ECOLI Escherichia coli (strain K12) # PATRIC 32120321 VBIEscCol129921_2563 # PIR D65022 D65022 # PROSITE PS50109 HIS_KIN # PROSITE PS50885 HAMP # Pfam PF00672 HAMP # Pfam PF02518 HATPase_c # Pfam PF07730 HisKA_3 # Pfam PF13675 PilJ # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NARQ_ECOLI Nitrate/nitrite sensor protein NarQ # RefSeq NP_416964 NC_000913.3 # RefSeq WP_001300881 NZ_CP014272.1 # SIMILARITY Contains 1 HAMP domain. {ECO:0000255|PROSITE- ProRule PRU00102}. # SIMILARITY Contains 1 histidine kinase domain. {ECO:0000255|PROSITE-ProRule PRU00107}. # SMART SM00304 HAMP # SMART SM00387 HATPase_c # SUBCELLULAR LOCATION NARQ_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # SUPFAM SSF55874 SSF55874 # eggNOG ENOG4105BZU Bacteria # eggNOG ENOG410XNMH LUCA BLAST swissprot:NARQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NARQ_ECOLI BioCyc ECOL316407:JW2453-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2453-MONOMER BioCyc EcoCyc:NARQ-MONOMER http://biocyc.org/getid?id=EcoCyc:NARQ-MONOMER COG COG3850 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3850 DIP DIP-10318N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10318N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.89.18.8419 http://dx.doi.org/10.1073/pnas.89.18.8419 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1365-2958.1992.tb01364.x http://dx.doi.org/10.1111/j.1365-2958.1992.tb01364.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.13.3 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.13.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M94724 http://www.ebi.ac.uk/ena/data/view/M94724 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U12598 http://www.ebi.ac.uk/ena/data/view/U12598 EMBL X65714 http://www.ebi.ac.uk/ena/data/view/X65714 ENZYME 2.7.13.3 http://enzyme.expasy.org/EC/2.7.13.3 EchoBASE EB1429 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1429 EcoGene EG11460 http://www.ecogene.org/geneInfo.php?eg_id=EG11460 EnsemblBacteria AAC75522 http://www.ensemblgenomes.org/id/AAC75522 EnsemblBacteria AAC75522 http://www.ensemblgenomes.org/id/AAC75522 EnsemblBacteria BAA16343 http://www.ensemblgenomes.org/id/BAA16343 EnsemblBacteria BAA16343 http://www.ensemblgenomes.org/id/BAA16343 EnsemblBacteria BAA16343 http://www.ensemblgenomes.org/id/BAA16343 EnsemblBacteria b2469 http://www.ensemblgenomes.org/id/b2469 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0000155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000155 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0042128 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042128 GO_process GO:0071249 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071249 GO_process GO:0071250 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071250 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0071941 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071941 Gene3D 3.30.565.10 http://www.cathdb.info/version/latest/superfamily/3.30.565.10 GeneID 946948 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946948 HOGENOM HOG000275465 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275465&db=HOGENOM6 InParanoid P27896 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P27896 IntAct P27896 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P27896* IntEnz 2.7.13.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.13.3 InterPro IPR003594 http://www.ebi.ac.uk/interpro/entry/IPR003594 InterPro IPR003660 http://www.ebi.ac.uk/interpro/entry/IPR003660 InterPro IPR005467 http://www.ebi.ac.uk/interpro/entry/IPR005467 InterPro IPR011712 http://www.ebi.ac.uk/interpro/entry/IPR011712 InterPro IPR029095 http://www.ebi.ac.uk/interpro/entry/IPR029095 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01001 http://www.genome.jp/dbget-bin/www_bget?ko01001 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW2453 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2453 KEGG_Gene eco:b2469 http://www.genome.jp/dbget-bin/www_bget?eco:b2469 KEGG_Orthology KO:K07674 http://www.genome.jp/dbget-bin/www_bget?KO:K07674 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 MINT MINT-1307707 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1307707 OMA FLQIQLT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FLQIQLT PROSITE PS50109 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50109 PROSITE PS50885 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50885 PSORT swissprot:NARQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NARQ_ECOLI PSORT-B swissprot:NARQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NARQ_ECOLI PSORT2 swissprot:NARQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NARQ_ECOLI Pfam PF00672 http://pfam.xfam.org/family/PF00672 Pfam PF02518 http://pfam.xfam.org/family/PF02518 Pfam PF07730 http://pfam.xfam.org/family/PF07730 Pfam PF13675 http://pfam.xfam.org/family/PF13675 Phobius swissprot:NARQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NARQ_ECOLI PhylomeDB P27896 http://phylomedb.org/?seqid=P27896 ProteinModelPortal P27896 http://www.proteinmodelportal.org/query/uniprot/P27896 PubMed 1508040 http://www.ncbi.nlm.nih.gov/pubmed/1508040 PubMed 1528845 http://www.ncbi.nlm.nih.gov/pubmed/1528845 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416964 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416964 RefSeq WP_001300881 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300881 SMART SM00304 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00304 SMART SM00387 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00387 SMR P27896 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P27896 STRING 511145.b2469 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2469&targetmode=cogs STRING COG3850 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3850&targetmode=cogs SUPFAM SSF55874 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55874 UniProtKB NARQ_ECOLI http://www.uniprot.org/uniprot/NARQ_ECOLI UniProtKB-AC P27896 http://www.uniprot.org/uniprot/P27896 charge swissprot:NARQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NARQ_ECOLI eggNOG ENOG4105BZU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZU eggNOG ENOG410XNMH http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNMH epestfind swissprot:NARQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NARQ_ECOLI garnier swissprot:NARQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NARQ_ECOLI helixturnhelix swissprot:NARQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NARQ_ECOLI hmoment swissprot:NARQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NARQ_ECOLI iep swissprot:NARQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NARQ_ECOLI inforesidue swissprot:NARQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NARQ_ECOLI octanol swissprot:NARQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NARQ_ECOLI pepcoil swissprot:NARQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NARQ_ECOLI pepdigest swissprot:NARQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NARQ_ECOLI pepinfo swissprot:NARQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NARQ_ECOLI pepnet swissprot:NARQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NARQ_ECOLI pepstats swissprot:NARQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NARQ_ECOLI pepwheel swissprot:NARQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NARQ_ECOLI pepwindow swissprot:NARQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NARQ_ECOLI sigcleave swissprot:NARQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NARQ_ECOLI ## Database ID URL or Descriptions # AltName Alpha-IPM isomerase {ECO:0000255|HAMAP-Rule MF_01026} # AltName Isopropylmalate isomerase {ECO:0000255|HAMAP-Rule MF_01026} # BioGrid 4262050 14 # CATALYTIC ACTIVITY (2R,3S)-3-isopropylmalate = (2S)-2- isopropylmalate. {ECO:0000255|HAMAP-Rule MF_01026}. # CDD cd01583 IPMI # COFACTOR LEUC_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000255|HAMAP-Rule MF_01026}; Note=Binds 1 [4Fe-4S] cluster per subunit. {ECO 0000255|HAMAP- Rule MF_01026}; # EcoGene EG11576 leuC # FUNCTION LEUC_ECOLI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003861 3-isopropylmalate dehydratase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0016836 hydro-lyase activity; IDA:EcoCyc. # GO_function GO:0016866 intramolecular transferase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0009082 branched-chain amino acid biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0009098 leucine biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.30.499.10 -; 2. # Gene3D 3.40.1060.10 -; 1. # HAMAP MF_01026 LeuC_type1 # INTERACTION LEUC_ECOLI P30126 leuD; NbExp=4; IntAct=EBI-1113576, EBI-1113528; # IntAct P0A6A6 3 # InterPro IPR001030 Acoase/IPM_deHydtase_lsu_aba # InterPro IPR004430 3-IsopropMal_deHydase_lsu # InterPro IPR015931 Acnase/IPM_dHydase_lsu_aba_1/3 # InterPro IPR015932 Aconitase/IPMdHydase_lsu_aba_2 # InterPro IPR015937 Acoase/IPM_deHydtase # InterPro IPR018136 Aconitase_4Fe-4S_BS # InterPro IPR033941 IPMI_cat # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00290 Valine, leucine and isoleucine biosynthesis # KEGG_Pathway ko00660 C5-Branched dibasic acid metabolism # Organism LEUC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11670 PTHR11670; 2 # PATHWAY Amino-acid biosynthesis; L-leucine biosynthesis; L- leucine from 3-methyl-2-oxobutanoate: step 2/4. {ECO 0000255|HAMAP-Rule:MF_01026}. # PATRIC 32115247 VBIEscCol129921_0075 # PIR H64728 H64728 # PRINTS PR00415 ACONITASE # PROSITE PS00450 ACONITASE_1 # PROSITE PS01244 ACONITASE_2 # Pfam PF00330 Aconitase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 3-isopropylmalate dehydratase large subunit {ECO:0000255|HAMAP-Rule MF_01026} # RefSeq NP_414614 NC_000913.3 # RefSeq WP_001140652 NZ_LN832404.1 # SIMILARITY Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily. {ECO:0000255|HAMAP-Rule MF_01026}. # SUBUNIT Heterodimer of LeuC and LeuD. {ECO:0000255|HAMAP- Rule MF_01026}. # SUPFAM SSF53732 SSF53732 # TIGRFAMs TIGR00170 leuC # UniPathway UPA00048 UER00071 # eggNOG COG0065 LUCA # eggNOG ENOG4105CQI Bacteria BLAST swissprot:LEUC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LEUC_ECOLI BioCyc ECOL316407:JW0071-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0071-MONOMER BioCyc EcoCyc:LEUC-MONOMER http://biocyc.org/getid?id=EcoCyc:LEUC-MONOMER BioCyc MetaCyc:LEUC-MONOMER http://biocyc.org/getid?id=MetaCyc:LEUC-MONOMER COG COG0065 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0065 DIP DIP-35834N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35834N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1002/elps.1150191114 http://dx.doi.org/10.1002/elps.1150191114 DOI 10.1006/jmbi.1998.1726 http://dx.doi.org/10.1006/jmbi.1998.1726 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/18.23.7185 http://dx.doi.org/10.1093/nar/18.23.7185 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1111/j.1432-1033.1994.tb18623.x http://dx.doi.org/10.1111/j.1432-1033.1994.tb18623.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.1.33 {ECO:0000255|HAMAP-Rule:MF_01026} http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.33 {ECO:0000255|HAMAP-Rule:MF_01026} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D17631 http://www.ebi.ac.uk/ena/data/view/D17631 EMBL D17632 http://www.ebi.ac.uk/ena/data/view/D17632 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 4.2.1.33 {ECO:0000255|HAMAP-Rule:MF_01026} http://enzyme.expasy.org/EC/4.2.1.33 {ECO:0000255|HAMAP-Rule:MF_01026} EchoBASE EB1536 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1536 EcoGene EG11576 http://www.ecogene.org/geneInfo.php?eg_id=EG11576 EnsemblBacteria AAC73183 http://www.ensemblgenomes.org/id/AAC73183 EnsemblBacteria AAC73183 http://www.ensemblgenomes.org/id/AAC73183 EnsemblBacteria BAB96641 http://www.ensemblgenomes.org/id/BAB96641 EnsemblBacteria BAB96641 http://www.ensemblgenomes.org/id/BAB96641 EnsemblBacteria BAB96641 http://www.ensemblgenomes.org/id/BAB96641 EnsemblBacteria b0072 http://www.ensemblgenomes.org/id/b0072 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003861 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003861 GO_function GO:0016836 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016836 GO_function GO:0016866 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016866 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0009082 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009082 GO_process GO:0009098 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009098 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.30.499.10 http://www.cathdb.info/version/latest/superfamily/3.30.499.10 Gene3D 3.40.1060.10 http://www.cathdb.info/version/latest/superfamily/3.40.1060.10 GeneID 945076 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945076 HAMAP MF_01026 http://hamap.expasy.org/unirule/MF_01026 HOGENOM HOG000226972 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000226972&db=HOGENOM6 InParanoid P0A6A6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6A6 IntAct P0A6A6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6A6* IntEnz 4.2.1.33 {ECO:0000255|HAMAP-Rule:MF_01026} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.33 {ECO:0000255|HAMAP-Rule:MF_01026} InterPro IPR001030 http://www.ebi.ac.uk/interpro/entry/IPR001030 InterPro IPR004430 http://www.ebi.ac.uk/interpro/entry/IPR004430 InterPro IPR015931 http://www.ebi.ac.uk/interpro/entry/IPR015931 InterPro IPR015932 http://www.ebi.ac.uk/interpro/entry/IPR015932 InterPro IPR015937 http://www.ebi.ac.uk/interpro/entry/IPR015937 InterPro IPR018136 http://www.ebi.ac.uk/interpro/entry/IPR018136 InterPro IPR033941 http://www.ebi.ac.uk/interpro/entry/IPR033941 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0071 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0071 KEGG_Gene eco:b0072 http://www.genome.jp/dbget-bin/www_bget?eco:b0072 KEGG_Orthology KO:K01703 http://www.genome.jp/dbget-bin/www_bget?KO:K01703 KEGG_Pathway ko00290 http://www.genome.jp/kegg-bin/show_pathway?ko00290 KEGG_Pathway ko00660 http://www.genome.jp/kegg-bin/show_pathway?ko00660 KEGG_Reaction rn:R03896 http://www.genome.jp/dbget-bin/www_bget?rn:R03896 KEGG_Reaction rn:R03898 http://www.genome.jp/dbget-bin/www_bget?rn:R03898 KEGG_Reaction rn:R03968 http://www.genome.jp/dbget-bin/www_bget?rn:R03968 KEGG_Reaction rn:R04001 http://www.genome.jp/dbget-bin/www_bget?rn:R04001 KEGG_Reaction rn:R10170 http://www.genome.jp/dbget-bin/www_bget?rn:R10170 OMA IDVCFIG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IDVCFIG PANTHER PTHR11670 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11670 PRINTS PR00415 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00415 PROSITE PS00450 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00450 PROSITE PS01244 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01244 PSORT swissprot:LEUC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LEUC_ECOLI PSORT-B swissprot:LEUC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LEUC_ECOLI PSORT2 swissprot:LEUC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LEUC_ECOLI Pfam PF00330 http://pfam.xfam.org/family/PF00330 Phobius swissprot:LEUC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LEUC_ECOLI PhylomeDB P0A6A6 http://phylomedb.org/?seqid=P0A6A6 ProteinModelPortal P0A6A6 http://www.proteinmodelportal.org/query/uniprot/P0A6A6 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2124684 http://www.ncbi.nlm.nih.gov/pubmed/2124684 PubMed 8119295 http://www.ncbi.nlm.nih.gov/pubmed/8119295 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 PubMed 9740056 http://www.ncbi.nlm.nih.gov/pubmed/9740056 RefSeq NP_414614 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414614 RefSeq WP_001140652 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001140652 STRING 511145.b0072 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0072&targetmode=cogs STRING COG0065 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0065&targetmode=cogs SUPFAM SSF53732 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53732 SWISS-2DPAGE P0A6A6 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A6A6 TIGRFAMs TIGR00170 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00170 UniProtKB LEUC_ECOLI http://www.uniprot.org/uniprot/LEUC_ECOLI UniProtKB-AC P0A6A6 http://www.uniprot.org/uniprot/P0A6A6 charge swissprot:LEUC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LEUC_ECOLI eggNOG COG0065 http://eggnogapi.embl.de/nog_data/html/tree/COG0065 eggNOG ENOG4105CQI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CQI epestfind swissprot:LEUC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LEUC_ECOLI garnier swissprot:LEUC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LEUC_ECOLI helixturnhelix swissprot:LEUC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LEUC_ECOLI hmoment swissprot:LEUC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LEUC_ECOLI iep swissprot:LEUC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LEUC_ECOLI inforesidue swissprot:LEUC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LEUC_ECOLI octanol swissprot:LEUC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LEUC_ECOLI pepcoil swissprot:LEUC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LEUC_ECOLI pepdigest swissprot:LEUC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LEUC_ECOLI pepinfo swissprot:LEUC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LEUC_ECOLI pepnet swissprot:LEUC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LEUC_ECOLI pepstats swissprot:LEUC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LEUC_ECOLI pepwheel swissprot:LEUC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LEUC_ECOLI pepwindow swissprot:LEUC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LEUC_ECOLI sigcleave swissprot:LEUC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LEUC_ECOLI ## Database ID URL or Descriptions # BioGrid 4259633 49 # EcoGene EG13932 ydgK # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR019690 DUF2569 # Organism YDGK_ECOLI Escherichia coli (strain K12) # PATRIC 32118554 VBIEscCol129921_1697 # PIR D64919 D64919 # Pfam PF10754 DUF2569 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDGK_ECOLI Inner membrane protein YdgK # RefSeq NP_416143 NC_000913.3 # RefSeq WP_001310854 NZ_LN832404.1 # SIMILARITY To Synechocystis PCC 6803 sll0481. {ECO 0000305}. # SUBCELLULAR LOCATION YDGK_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG ENOG4105M9B Bacteria # eggNOG ENOG4111W7W LUCA BLAST swissprot:YDGK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDGK_ECOLI BioCyc ECOL316407:JW1618-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1618-MONOMER BioCyc EcoCyc:G6870-MONOMER http://biocyc.org/getid?id=EcoCyc:G6870-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3691 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3691 EcoGene EG13932 http://www.ecogene.org/geneInfo.php?eg_id=EG13932 EnsemblBacteria AAC74698 http://www.ensemblgenomes.org/id/AAC74698 EnsemblBacteria AAC74698 http://www.ensemblgenomes.org/id/AAC74698 EnsemblBacteria BAE76485 http://www.ensemblgenomes.org/id/BAE76485 EnsemblBacteria BAE76485 http://www.ensemblgenomes.org/id/BAE76485 EnsemblBacteria BAE76485 http://www.ensemblgenomes.org/id/BAE76485 EnsemblBacteria b1626 http://www.ensemblgenomes.org/id/b1626 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 946154 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946154 HOGENOM HOG000120897 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120897&db=HOGENOM6 IntAct P76180 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76180* InterPro IPR019690 http://www.ebi.ac.uk/interpro/entry/IPR019690 KEGG_Gene ecj:JW1618 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1618 KEGG_Gene eco:b1626 http://www.genome.jp/dbget-bin/www_bget?eco:b1626 OMA MWCFTLW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MWCFTLW PSORT swissprot:YDGK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDGK_ECOLI PSORT-B swissprot:YDGK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDGK_ECOLI PSORT2 swissprot:YDGK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDGK_ECOLI Pfam PF10754 http://pfam.xfam.org/family/PF10754 Phobius swissprot:YDGK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDGK_ECOLI ProteinModelPortal P76180 http://www.proteinmodelportal.org/query/uniprot/P76180 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416143 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416143 RefSeq WP_001310854 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001310854 STRING 511145.b1626 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1626&targetmode=cogs UniProtKB YDGK_ECOLI http://www.uniprot.org/uniprot/YDGK_ECOLI UniProtKB-AC P76180 http://www.uniprot.org/uniprot/P76180 charge swissprot:YDGK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDGK_ECOLI eggNOG ENOG4105M9B http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105M9B eggNOG ENOG4111W7W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111W7W epestfind swissprot:YDGK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDGK_ECOLI garnier swissprot:YDGK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDGK_ECOLI helixturnhelix swissprot:YDGK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDGK_ECOLI hmoment swissprot:YDGK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDGK_ECOLI iep swissprot:YDGK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDGK_ECOLI inforesidue swissprot:YDGK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDGK_ECOLI octanol swissprot:YDGK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDGK_ECOLI pepcoil swissprot:YDGK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDGK_ECOLI pepdigest swissprot:YDGK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDGK_ECOLI pepinfo swissprot:YDGK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDGK_ECOLI pepnet swissprot:YDGK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDGK_ECOLI pepstats swissprot:YDGK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDGK_ECOLI pepwheel swissprot:YDGK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDGK_ECOLI pepwindow swissprot:YDGK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDGK_ECOLI sigcleave swissprot:YDGK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDGK_ECOLI ## Database ID URL or Descriptions # AltName RCDA_ECOLI Regulator of csgD # BioGrid 4262832 5 # EcoGene EG13680 rcdA # FUNCTION RCDA_ECOLI Regulates the expression of a number of genes involved in biofilm formation and stress response. Target genes include six stress-response transcriptional regulators csgD, which is a master regulator of biofilm formation, appY, sxy, ycgF, fimB and rcdA itself. This indicates that a large number of genes must be regulated indirectly via these transcriptional regulators. Acts by binding to the upstream region of its target genes. {ECO 0000269|PubMed 23233451}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0000976 transcription regulatory region sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IBA:GO_Central. # GO_process GO:0006351 transcription, DNA-templated; IEP:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.357.10 -; 1. # INDUCTION Autoregulated. {ECO:0000269|PubMed 23233451}. # InterPro IPR001647 HTH_TetR # InterPro IPR009057 Homeodomain-like # InterPro IPR011075 Tet_transcr_reg_TetR-rel_C # InterPro IPR015893 Tet_transcr_reg_TetR-like_C # MISCELLANEOUS Has a strong cooperative DNA-binding mode, leading to aggregation of RcdA-DNA complexes. {ECO:0000305|PubMed 23233451}. # Organism RCDA_ECOLI Escherichia coli (strain K12) # PATRIC 32116897 VBIEscCol129921_0874 # PIR F64822 F64822 # PROSITE PS50977 HTH_TETR_2 # Pfam PF00440 TetR_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RCDA_ECOLI HTH-type transcriptional regulator RcdA # RefSeq NP_415367 NC_000913.3 # RefSeq WP_001295289 NZ_LN832404.1 # SIMILARITY Contains 1 HTH tetR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00335}. # SUPFAM SSF46689 SSF46689 # SUPFAM SSF48498 SSF48498 # eggNOG COG3226 LUCA # eggNOG ENOG4108RFG Bacteria BLAST swissprot:RCDA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RCDA_ECOLI BioCyc ECOL316407:JW5114-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5114-MONOMER BioCyc EcoCyc:G6444-MONOMER http://biocyc.org/getid?id=EcoCyc:G6444-MONOMER DOI 10.1002/mbo3.42 http://dx.doi.org/10.1002/mbo3.42 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3444 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3444 EcoGene EG13680 http://www.ecogene.org/geneInfo.php?eg_id=EG13680 EnsemblBacteria AAC73933 http://www.ensemblgenomes.org/id/AAC73933 EnsemblBacteria AAC73933 http://www.ensemblgenomes.org/id/AAC73933 EnsemblBacteria BAA35550 http://www.ensemblgenomes.org/id/BAA35550 EnsemblBacteria BAA35550 http://www.ensemblgenomes.org/id/BAA35550 EnsemblBacteria BAA35550 http://www.ensemblgenomes.org/id/BAA35550 EnsemblBacteria b0846 http://www.ensemblgenomes.org/id/b0846 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000976 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000976 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.357.10 http://www.cathdb.info/version/latest/superfamily/1.10.357.10 GeneID 945473 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945473 HOGENOM HOG000042836 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000042836&db=HOGENOM6 InParanoid P75811 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75811 InterPro IPR001647 http://www.ebi.ac.uk/interpro/entry/IPR001647 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR011075 http://www.ebi.ac.uk/interpro/entry/IPR011075 InterPro IPR015893 http://www.ebi.ac.uk/interpro/entry/IPR015893 KEGG_Gene ecj:JW5114 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5114 KEGG_Gene eco:b0846 http://www.genome.jp/dbget-bin/www_bget?eco:b0846 OMA RKIASCA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RKIASCA PROSITE PS50977 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50977 PSORT swissprot:RCDA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RCDA_ECOLI PSORT-B swissprot:RCDA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RCDA_ECOLI PSORT2 swissprot:RCDA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RCDA_ECOLI Pfam PF00440 http://pfam.xfam.org/family/PF00440 Phobius swissprot:RCDA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RCDA_ECOLI PhylomeDB P75811 http://phylomedb.org/?seqid=P75811 ProteinModelPortal P75811 http://www.proteinmodelportal.org/query/uniprot/P75811 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 23233451 http://www.ncbi.nlm.nih.gov/pubmed/23233451 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415367 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415367 RefSeq WP_001295289 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295289 SMR P75811 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75811 STRING 511145.b0846 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0846&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF48498 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48498 UniProtKB RCDA_ECOLI http://www.uniprot.org/uniprot/RCDA_ECOLI UniProtKB-AC P75811 http://www.uniprot.org/uniprot/P75811 charge swissprot:RCDA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RCDA_ECOLI eggNOG COG3226 http://eggnogapi.embl.de/nog_data/html/tree/COG3226 eggNOG ENOG4108RFG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108RFG epestfind swissprot:RCDA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RCDA_ECOLI garnier swissprot:RCDA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RCDA_ECOLI helixturnhelix swissprot:RCDA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RCDA_ECOLI hmoment swissprot:RCDA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RCDA_ECOLI iep swissprot:RCDA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RCDA_ECOLI inforesidue swissprot:RCDA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RCDA_ECOLI octanol swissprot:RCDA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RCDA_ECOLI pepcoil swissprot:RCDA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RCDA_ECOLI pepdigest swissprot:RCDA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RCDA_ECOLI pepinfo swissprot:RCDA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RCDA_ECOLI pepnet swissprot:RCDA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RCDA_ECOLI pepstats swissprot:RCDA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RCDA_ECOLI pepwheel swissprot:RCDA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RCDA_ECOLI pepwindow swissprot:RCDA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RCDA_ECOLI sigcleave swissprot:RCDA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RCDA_ECOLI ## Database ID URL or Descriptions # AltName KDSA_ECOLI 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase # AltName KDSA_ECOLI KDO-8-phosphate synthase # AltName KDSA_ECOLI Phospho-2-dehydro-3-deoxyoctonate aldolase # BRENDA 2.5.1.55 2026 # BioGrid 4260117 422 # CATALYTIC ACTIVITY KDSA_ECOLI Phosphoenolpyruvate + D-arabinose 5-phosphate + H(2)O = 3-deoxy-D-manno-octulosonate 8-phosphate + phosphate. # EcoGene EG10518 kdsA # FUNCTION KDSA_ECOLI Synthesis of KDO 8-P which is required for lipid A maturation and cellular growth. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0008676 3-deoxy-8-phosphooctulonate synthase activity; IDA:EcoCyc. # GO_process GO:0019294 keto-3-deoxy-D-manno-octulosonic acid biosynthetic process; IDA:EcoCyc. # GO_process GO:0051289 protein homotetramerization; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.70 -; 1. # HAMAP MF_00056 KDO8P_synth # IntAct P0A715 46 # InterPro IPR006218 DAHP1/KDSA # InterPro IPR006269 KDO8P_synthase # InterPro IPR013785 Aldolase_TIM # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # KEGG_Pathway ko00540 Lipopolysaccharide biosynthesis # MASS SPECTROMETRY Mass=30842; Mass_error=17; Method=Electrospray; Range=1-284; Evidence={ECO:0000269|PubMed 11371194}; # Organism KDSA_ECOLI Escherichia coli (strain K12) # PATHWAY Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5- phosphate step 2/3. # PATHWAY KDSA_ECOLI Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. # PATRIC 32117682 VBIEscCol129921_1263 # PDB 1D9E X-ray; 2.40 A; A/B/C/D=1-284 # PDB 1G7U X-ray; 2.80 A; A=1-284 # PDB 1G7V X-ray; 2.40 A; A=1-284 # PDB 1GG0 X-ray; 3.00 A; A=1-284 # PDB 1PHQ X-ray; 2.70 A; A=1-284 # PDB 1PHW X-ray; 2.36 A; A=1-284 # PDB 1PL9 X-ray; 2.90 A; A=1-284 # PDB 1Q3N X-ray; 2.70 A; A=1-284 # PDB 1X6U X-ray; 2.70 A; A=1-284 # PDB 1X8F X-ray; 2.40 A; A=1-284 # PIR I83573 SYECOL # Pfam PF00793 DAHP_synth_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName KDSA_ECOLI 2-dehydro-3-deoxyphosphooctonate aldolase # RefSeq NP_415733 NC_000913.3 # RefSeq WP_000811065 NZ_LN832404.1 # SIMILARITY Belongs to the KdsA family. {ECO 0000305}. # SUBCELLULAR LOCATION KDSA_ECOLI Cytoplasm. # SUBUNIT KDSA_ECOLI Homotrimer. # TIGRFAMs TIGR01362 KDO8P_synth # UniPathway UPA00357 UER00474 # eggNOG COG2877 LUCA # eggNOG ENOG4105CXR Bacteria BLAST swissprot:KDSA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:KDSA_ECOLI BioCyc ECOL316407:JW1206-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1206-MONOMER BioCyc EcoCyc:KDO-8PSYNTH-MONOMER http://biocyc.org/getid?id=EcoCyc:KDO-8PSYNTH-MONOMER BioCyc MetaCyc:KDO-8PSYNTH-MONOMER http://biocyc.org/getid?id=MetaCyc:KDO-8PSYNTH-MONOMER COG COG2877 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2877 DIP DIP-35940N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35940N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.2000.3956 http://dx.doi.org/10.1006/jmbi.2000.3956 DOI 10.1007/BF00331603 http://dx.doi.org/10.1007/BF00331603 DOI 10.1021/bi010339d http://dx.doi.org/10.1021/bi010339d DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.270.23.13698 http://dx.doi.org/10.1074/jbc.270.23.13698 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.5.1.55 http://www.genome.jp/dbget-bin/www_bget?EC:2.5.1.55 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18555 http://www.ebi.ac.uk/ena/data/view/U18555 EMBL X05552 http://www.ebi.ac.uk/ena/data/view/X05552 ENZYME 2.5.1.55 http://enzyme.expasy.org/EC/2.5.1.55 EchoBASE EB0513 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0513 EcoGene EG10518 http://www.ecogene.org/geneInfo.php?eg_id=EG10518 EnsemblBacteria AAC74299 http://www.ensemblgenomes.org/id/AAC74299 EnsemblBacteria AAC74299 http://www.ensemblgenomes.org/id/AAC74299 EnsemblBacteria BAA36073 http://www.ensemblgenomes.org/id/BAA36073 EnsemblBacteria BAA36073 http://www.ensemblgenomes.org/id/BAA36073 EnsemblBacteria BAA36073 http://www.ensemblgenomes.org/id/BAA36073 EnsemblBacteria b1215 http://www.ensemblgenomes.org/id/b1215 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008676 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008676 GO_process GO:0019294 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019294 GO_process GO:0051289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051289 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016765 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 945785 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945785 HAMAP MF_00056 http://hamap.expasy.org/unirule/MF_00056 HOGENOM HOG000023021 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000023021&db=HOGENOM6 InParanoid P0A715 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A715 IntAct P0A715 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A715* IntEnz 2.5.1.55 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.5.1.55 InterPro IPR006218 http://www.ebi.ac.uk/interpro/entry/IPR006218 InterPro IPR006269 http://www.ebi.ac.uk/interpro/entry/IPR006269 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Gene ecj:JW1206 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1206 KEGG_Gene eco:b1215 http://www.genome.jp/dbget-bin/www_bget?eco:b1215 KEGG_Orthology KO:K01627 http://www.genome.jp/dbget-bin/www_bget?KO:K01627 KEGG_Pathway ko00540 http://www.genome.jp/kegg-bin/show_pathway?ko00540 KEGG_Reaction rn:R03254 http://www.genome.jp/dbget-bin/www_bget?rn:R03254 MINT MINT-1220797 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1220797 OMA FRGIPTM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FRGIPTM PDB 1D9E http://www.ebi.ac.uk/pdbe-srv/view/entry/1D9E PDB 1G7U http://www.ebi.ac.uk/pdbe-srv/view/entry/1G7U PDB 1G7V http://www.ebi.ac.uk/pdbe-srv/view/entry/1G7V PDB 1GG0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1GG0 PDB 1PHQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1PHQ PDB 1PHW http://www.ebi.ac.uk/pdbe-srv/view/entry/1PHW PDB 1PL9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1PL9 PDB 1Q3N http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q3N PDB 1X6U http://www.ebi.ac.uk/pdbe-srv/view/entry/1X6U PDB 1X8F http://www.ebi.ac.uk/pdbe-srv/view/entry/1X8F PDBsum 1D9E http://www.ebi.ac.uk/pdbsum/1D9E PDBsum 1G7U http://www.ebi.ac.uk/pdbsum/1G7U PDBsum 1G7V http://www.ebi.ac.uk/pdbsum/1G7V PDBsum 1GG0 http://www.ebi.ac.uk/pdbsum/1GG0 PDBsum 1PHQ http://www.ebi.ac.uk/pdbsum/1PHQ PDBsum 1PHW http://www.ebi.ac.uk/pdbsum/1PHW PDBsum 1PL9 http://www.ebi.ac.uk/pdbsum/1PL9 PDBsum 1Q3N http://www.ebi.ac.uk/pdbsum/1Q3N PDBsum 1X6U http://www.ebi.ac.uk/pdbsum/1X6U PDBsum 1X8F http://www.ebi.ac.uk/pdbsum/1X8F PSORT swissprot:KDSA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:KDSA_ECOLI PSORT-B swissprot:KDSA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:KDSA_ECOLI PSORT2 swissprot:KDSA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:KDSA_ECOLI Pfam PF00793 http://pfam.xfam.org/family/PF00793 Phobius swissprot:KDSA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:KDSA_ECOLI PhylomeDB P0A715 http://phylomedb.org/?seqid=P0A715 ProteinModelPortal P0A715 http://www.proteinmodelportal.org/query/uniprot/P0A715 PubMed 10926505 http://www.ncbi.nlm.nih.gov/pubmed/10926505 PubMed 11371194 http://www.ncbi.nlm.nih.gov/pubmed/11371194 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3039295 http://www.ncbi.nlm.nih.gov/pubmed/3039295 PubMed 7543480 http://www.ncbi.nlm.nih.gov/pubmed/7543480 PubMed 7775423 http://www.ncbi.nlm.nih.gov/pubmed/7775423 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_415733 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415733 RefSeq WP_000811065 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000811065 SMR P0A715 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A715 STRING 511145.b1215 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1215&targetmode=cogs STRING COG2877 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2877&targetmode=cogs SWISS-2DPAGE P0A715 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A715 TIGRFAMs TIGR01362 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01362 UniProtKB KDSA_ECOLI http://www.uniprot.org/uniprot/KDSA_ECOLI UniProtKB-AC P0A715 http://www.uniprot.org/uniprot/P0A715 charge swissprot:KDSA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:KDSA_ECOLI eggNOG COG2877 http://eggnogapi.embl.de/nog_data/html/tree/COG2877 eggNOG ENOG4105CXR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CXR epestfind swissprot:KDSA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:KDSA_ECOLI garnier swissprot:KDSA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:KDSA_ECOLI helixturnhelix swissprot:KDSA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:KDSA_ECOLI hmoment swissprot:KDSA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:KDSA_ECOLI iep swissprot:KDSA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:KDSA_ECOLI inforesidue swissprot:KDSA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:KDSA_ECOLI octanol swissprot:KDSA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:KDSA_ECOLI pepcoil swissprot:KDSA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:KDSA_ECOLI pepdigest swissprot:KDSA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:KDSA_ECOLI pepinfo swissprot:KDSA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:KDSA_ECOLI pepnet swissprot:KDSA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:KDSA_ECOLI pepstats swissprot:KDSA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:KDSA_ECOLI pepwheel swissprot:KDSA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:KDSA_ECOLI pepwindow swissprot:KDSA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:KDSA_ECOLI sigcleave swissprot:KDSA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:KDSA_ECOLI ## Database ID URL or Descriptions # AltName FRMA_ECOLI Alcohol dehydrogenase class-3 # AltName FRMA_ECOLI Alcohol dehydrogenase class-III # AltName FRMA_ECOLI Glutathione-dependent formaldehyde dehydrogenase # BioGrid 4261803 12 # CATALYTIC ACTIVITY FRMA_ECOLI An alcohol + NAD(+) = an aldehyde or ketone + NADH. # CATALYTIC ACTIVITY FRMA_ECOLI S-(hydroxymethyl)glutathione + NAD(P)(+) = S- formylglutathione + NAD(P)H. # CDD cd08300 alcohol_DH_class_III # COFACTOR FRMA_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000250}; Note=Binds 2 Zn(2+) ions per subunit. {ECO 0000250}; # EcoGene EG50010 frmA # FUNCTION FRMA_ECOLI Has high formaldehyde dehydrogenase activity in the presence of glutathione and catalyzes the oxidation of normal alcohols in a reaction that is not GSH-dependent. In addition, hemithiolacetals other than those formed from GSH, including omega-thiol fatty acids, also are substrates. {ECO 0000269|PubMed 1731906}. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0004024 alcohol dehydrogenase activity, zinc-dependent; IDA:EcoliWiki. # GO_function GO:0008270 zinc ion binding; IDA:EcoliWiki. # GO_function GO:0051903 S-(hydroxymethyl)glutathione dehydrogenase activity; IDA:EcoliWiki. # GO_process GO:0006069 ethanol oxidation; IEA:InterPro. # GO_process GO:0046294 formaldehyde catabolic process; IMP:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.720 -; 1. # Gene3D 3.90.180.10 -; 1. # INDUCTION Induced by formaldehyde and repressed by FrmR. {ECO:0000269|PubMed 15466022}. # INTERACTION FRMA_ECOLI Self; NbExp=3; IntAct=EBI-556478, EBI-556478; # IntAct P25437 7 # InterPro IPR002085 ADH_SF_Zn-type # InterPro IPR002328 ADH_Zn_CS # InterPro IPR011032 GroES-like # InterPro IPR013149 ADH_C # InterPro IPR013154 ADH_N # InterPro IPR014183 ADH_3 # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR020843 PKS_ER # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00010 Glycolysis / Gluconeogenesis # KEGG_Pathway ko00071 Fatty acid metabolism # KEGG_Pathway ko00350 Tyrosine metabolism # KEGG_Pathway ko00625 Chloroalkane and chloroalkene degradation # KEGG_Pathway ko00626 Naphthalene degradation # KEGG_Pathway ko00680 Methane metabolism # KEGG_Pathway ko00830 Retinol metabolism # KEGG_Pathway ko00980 Metabolism of xenobiotics by cytochrome P450 # KEGG_Pathway ko00982 Drug metabolism - cytochrome P450 # KEGG_Pathway ko05204 Chemical carcinogenesis # Organism FRMA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11695 PTHR11695; 2 # PATRIC 32115851 VBIEscCol129921_0367 # PIR D64763 D64763 # PROSITE PS00059 ADH_ZINC # Pfam PF00107 ADH_zinc_N # Pfam PF08240 ADH_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FRMA_ECOLI S-(hydroxymethyl)glutathione dehydrogenase # RefSeq NP_414890 NC_000913.3 # RefSeq WP_000842106 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18081.1; Type=Frameshift; Positions=26; Evidence={ECO:0000305}; Sequence=BAA12834.1; Type=Frameshift; Positions=26; Evidence={ECO 0000305}; # SIMILARITY Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. {ECO 0000305}. # SMART SM00829 PKS_ER # SUBCELLULAR LOCATION FRMA_ECOLI Cytoplasm. # SUBUNIT Homodimer. {ECO:0000269|PubMed 1731906}. # SUPFAM SSF50129 SSF50129; 2 # SUPFAM SSF51735 SSF51735 # TIGRFAMs TIGR02818 adh_III_F_hyde # eggNOG COG1062 LUCA # eggNOG ENOG4108I9Z Bacteria BLAST swissprot:FRMA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FRMA_ECOLI BioCyc ECOL316407:JW0347-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0347-MONOMER BioCyc EcoCyc:ADHC-MONOMER http://biocyc.org/getid?id=EcoCyc:ADHC-MONOMER BioCyc MetaCyc:ADHC-MONOMER http://biocyc.org/getid?id=MetaCyc:ADHC-MONOMER COG COG1062 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1062 DIP DIP-2901N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-2901N DOI 10.1021/bi00117a025 http://dx.doi.org/10.1021/bi00117a025 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.186.20.6714-6720.2004 http://dx.doi.org/10.1128/JB.186.20.6714-6720.2004 EC_number EC:1.1.1.- http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.- EC_number EC:1.1.1.1 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.1 EC_number EC:1.1.1.284 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.284 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D38504 http://www.ebi.ac.uk/ena/data/view/D38504 EMBL D85613 http://www.ebi.ac.uk/ena/data/view/D85613 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 ENZYME 1.1.1.- http://enzyme.expasy.org/EC/1.1.1.- ENZYME 1.1.1.1 http://enzyme.expasy.org/EC/1.1.1.1 ENZYME 1.1.1.284 http://enzyme.expasy.org/EC/1.1.1.284 EchoBASE EB4303 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4303 EcoGene EG50010 http://www.ecogene.org/geneInfo.php?eg_id=EG50010 EnsemblBacteria AAC73459 http://www.ensemblgenomes.org/id/AAC73459 EnsemblBacteria AAC73459 http://www.ensemblgenomes.org/id/AAC73459 EnsemblBacteria BAE76138 http://www.ensemblgenomes.org/id/BAE76138 EnsemblBacteria BAE76138 http://www.ensemblgenomes.org/id/BAE76138 EnsemblBacteria BAE76138 http://www.ensemblgenomes.org/id/BAE76138 EnsemblBacteria b0356 http://www.ensemblgenomes.org/id/b0356 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004024 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004024 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0051903 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051903 GO_process GO:0006069 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006069 GO_process GO:0046294 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046294 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 Gene3D 3.90.180.10 http://www.cathdb.info/version/latest/superfamily/3.90.180.10 GeneID 944988 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944988 HOGENOM HOG000294674 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000294674&db=HOGENOM6 InParanoid P25437 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P25437 IntAct P25437 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P25437* IntEnz 1.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1 IntEnz 1.1.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.1 IntEnz 1.1.1.284 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.284 InterPro IPR002085 http://www.ebi.ac.uk/interpro/entry/IPR002085 InterPro IPR002328 http://www.ebi.ac.uk/interpro/entry/IPR002328 InterPro IPR011032 http://www.ebi.ac.uk/interpro/entry/IPR011032 InterPro IPR013149 http://www.ebi.ac.uk/interpro/entry/IPR013149 InterPro IPR013154 http://www.ebi.ac.uk/interpro/entry/IPR013154 InterPro IPR014183 http://www.ebi.ac.uk/interpro/entry/IPR014183 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR020843 http://www.ebi.ac.uk/interpro/entry/IPR020843 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0347 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0347 KEGG_Gene eco:b0356 http://www.genome.jp/dbget-bin/www_bget?eco:b0356 KEGG_Orthology KO:K00121 http://www.genome.jp/dbget-bin/www_bget?KO:K00121 KEGG_Pathway ko00010 http://www.genome.jp/kegg-bin/show_pathway?ko00010 KEGG_Pathway ko00071 http://www.genome.jp/kegg-bin/show_pathway?ko00071 KEGG_Pathway ko00350 http://www.genome.jp/kegg-bin/show_pathway?ko00350 KEGG_Pathway ko00625 http://www.genome.jp/kegg-bin/show_pathway?ko00625 KEGG_Pathway ko00626 http://www.genome.jp/kegg-bin/show_pathway?ko00626 KEGG_Pathway ko00680 http://www.genome.jp/kegg-bin/show_pathway?ko00680 KEGG_Pathway ko00830 http://www.genome.jp/kegg-bin/show_pathway?ko00830 KEGG_Pathway ko00980 http://www.genome.jp/kegg-bin/show_pathway?ko00980 KEGG_Pathway ko00982 http://www.genome.jp/kegg-bin/show_pathway?ko00982 KEGG_Pathway ko05204 http://www.genome.jp/kegg-bin/show_pathway?ko05204 KEGG_Reaction rn:R00623 http://www.genome.jp/dbget-bin/www_bget?rn:R00623 KEGG_Reaction rn:R00754 http://www.genome.jp/dbget-bin/www_bget?rn:R00754 KEGG_Reaction rn:R02124 http://www.genome.jp/dbget-bin/www_bget?rn:R02124 KEGG_Reaction rn:R04880 http://www.genome.jp/dbget-bin/www_bget?rn:R04880 KEGG_Reaction rn:R05233 http://www.genome.jp/dbget-bin/www_bget?rn:R05233 KEGG_Reaction rn:R05234 http://www.genome.jp/dbget-bin/www_bget?rn:R05234 KEGG_Reaction rn:R06917 http://www.genome.jp/dbget-bin/www_bget?rn:R06917 KEGG_Reaction rn:R06927 http://www.genome.jp/dbget-bin/www_bget?rn:R06927 KEGG_Reaction rn:R06983 http://www.genome.jp/dbget-bin/www_bget?rn:R06983 KEGG_Reaction rn:R07105 http://www.genome.jp/dbget-bin/www_bget?rn:R07105 KEGG_Reaction rn:R08281 http://www.genome.jp/dbget-bin/www_bget?rn:R08281 KEGG_Reaction rn:R08306 http://www.genome.jp/dbget-bin/www_bget?rn:R08306 KEGG_Reaction rn:R08310 http://www.genome.jp/dbget-bin/www_bget?rn:R08310 MINT MINT-1286770 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1286770 OMA MITHVLK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MITHVLK PANTHER PTHR11695 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11695 PROSITE PS00059 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00059 PSORT swissprot:FRMA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FRMA_ECOLI PSORT-B swissprot:FRMA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FRMA_ECOLI PSORT2 swissprot:FRMA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FRMA_ECOLI Pfam PF00107 http://pfam.xfam.org/family/PF00107 Pfam PF08240 http://pfam.xfam.org/family/PF08240 Phobius swissprot:FRMA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FRMA_ECOLI PhylomeDB P25437 http://phylomedb.org/?seqid=P25437 ProteinModelPortal P25437 http://www.proteinmodelportal.org/query/uniprot/P25437 PubMed 15466022 http://www.ncbi.nlm.nih.gov/pubmed/15466022 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1731906 http://www.ncbi.nlm.nih.gov/pubmed/1731906 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414890 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414890 RefSeq WP_000842106 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000842106 SMART SM00829 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00829 SMR P25437 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P25437 STRING 511145.b0356 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0356&targetmode=cogs STRING COG1062 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1062&targetmode=cogs SUPFAM SSF50129 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50129 SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 TIGRFAMs TIGR02818 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02818 UniProtKB FRMA_ECOLI http://www.uniprot.org/uniprot/FRMA_ECOLI UniProtKB-AC P25437 http://www.uniprot.org/uniprot/P25437 charge swissprot:FRMA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FRMA_ECOLI eggNOG COG1062 http://eggnogapi.embl.de/nog_data/html/tree/COG1062 eggNOG ENOG4108I9Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108I9Z epestfind swissprot:FRMA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FRMA_ECOLI garnier swissprot:FRMA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FRMA_ECOLI helixturnhelix swissprot:FRMA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FRMA_ECOLI hmoment swissprot:FRMA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FRMA_ECOLI iep swissprot:FRMA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FRMA_ECOLI inforesidue swissprot:FRMA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FRMA_ECOLI octanol swissprot:FRMA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FRMA_ECOLI pepcoil swissprot:FRMA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FRMA_ECOLI pepdigest swissprot:FRMA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FRMA_ECOLI pepinfo swissprot:FRMA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FRMA_ECOLI pepnet swissprot:FRMA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FRMA_ECOLI pepstats swissprot:FRMA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FRMA_ECOLI pepwheel swissprot:FRMA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FRMA_ECOLI pepwindow swissprot:FRMA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FRMA_ECOLI sigcleave swissprot:FRMA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FRMA_ECOLI ## Database ID URL or Descriptions # DISRUPTION PHENOTYPE MAZE_ECOLI Decreased sensitivity to dramatic intracellular increases of ppGpp. Double mazE-mazF disruptions survive high temperature, various DNA-damaging agents and H(2)O(2) exposure better than wild-type cells. They produce more P1 phage than wild-type cells, while introduction of lysogens into a growing non-lysogenic disruption culture is lethal (PubMed 15316771). Double mazE-mazF disruptions show reduced biofilm formation, and survive antibiotic treatment in log phase better than wild-type cells. Cells missing mazE-mazF survive hydroxyurea treatment better than wild-type; further disruption of relE-relB and tonB yields even better survival (PubMed 20005847). {ECO 0000269|PubMed 12972253, ECO 0000269|PubMed 15316771, ECO 0000269|PubMed 19707553, ECO 0000269|PubMed 20005847}. # EcoGene EG10571 mazE # FUNCTION MAZE_ECOLI Antitoxin component of a type II toxin-antitoxin (TA) module. Labile antitoxin that binds to the MazF endoribonuclease toxin and neutralizes its endoribonuclease activity. Is considered to be an 'addiction' molecule as the cell dies in its absence. Toxicity results when the levels of MazE decrease in the cell, leading to mRNA degradation. This effect can be rescued by expression of MazE, but after 6 hours in rich medium the overexpression of MazF leads to programmed cell death. Cell growth and viability are not affected when MazF and MazE are coexpressed. Both MazE and MazE-MazF bind to the promoter region of the mazE- mazF operon to inhibit their own transcription (PubMed 8650219). There are 3 operators to which MazE binds (PubMed 12533537). MazE has higher affinity for promoter DNA in the presence of MazF (PubMed 25564525). {ECO 0000269|PubMed 11071896, ECO 0000269|PubMed 12123459, ECO 0000269|PubMed 12533537, ECO 0000269|PubMed 19707553, ECO 0000269|PubMed 21419338, ECO 0000269|PubMed 25564525, ECO 0000269|PubMed 8650219}. # FUNCTION MAZE_ECOLI Cell death governed by the MazE-MazF and DinJ-YafQ TA modules seems to play a role in biofilm formation, while MazE-MazF is also implicated in cell death in liquid media. {ECO 0000269|PubMed 15576778, ECO 0000269|PubMed 19707553}. # FUNCTION MAZE_ECOLI Might also serve to protect cells against bacteriophage; in the presence of MazE-MazF fewer P1 phage are produced than in a disrupted strain. For strain K38 most wild-type cells are killed but not by phage lysis; it was suggested that MazE-MazF causes P1 phage exclusion from the bacterial population. This phenomenon is strain dependent. {ECO 0000269|PubMed 15316771}. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # INDUCTION MAZE_ECOLI Expressed in exponentially growing cells. Induction has been reported to occur after amino acid starvation in a ppGpp- independent fashion and to be Lon protease-dependent (PubMed 12972253), but also to not occur after amino acid starvation and to be regulated by ppGpp (PubMed 8650219). MazE alone and in combination with MazF, represses transcription of the mazE-mazF operon. Fis activates transcription. Part of the relA- mazE-mazF-mazG operon, there is also a second mazE-mazF specific promoter which is negatively autoregulated. This operon induced by ectopic expression of toxin RelE; induction of this operon by amino acid starvation requires the relBEF operon (PubMed 23432955). {ECO 0000269|PubMed 11071896, ECO 0000269|PubMed 12972253, ECO 0000269|PubMed 16390452, ECO 0000269|PubMed 23432955, ECO 0000269|PubMed 8650219}. # IntAct P0AE72 10 # InterPro IPR007159 SpoVT-AbrB_dom # Organism MAZE_ECOLI Escherichia coli (strain K12) # PATRIC 32120982 VBIEscCol129921_2883 # PDB 1MVF X-ray; 1.65 A; D/E=1-82 # PDB 1UB4 X-ray; 1.70 A; C=1-82 # PDB 2MRN NMR; -; A/B=2-50 # PDB 2MRU NMR; -; A/B=2-50 # PDB 5CQX X-ray; 1.63 A; C=68-82 # PDB 5CQY X-ray; 2.48 A; C=68-82 # PIR B31996 BVECZE # PROSITE PS51740 SPOVT_ABRB # PTM MAZE_ECOLI Degraded by the ClpPA and Lon proteases. {ECO 0000269|PubMed 12972253, ECO 0000269|PubMed 24375411, ECO 0000269|PubMed 8650219}. # Pfam PF04014 MazE_antitoxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MAZE_ECOLI Antitoxin MazE # RefSeq NP_417263 NC_000913.3 # RefSeq WP_000581937 NZ_LN832404.1 # SIMILARITY Belongs to the PemI family. {ECO 0000305}. # SIMILARITY Contains 1 SpoVT-AbrB domain. {ECO:0000255|PROSITE- ProRule PRU01076}. # SMART SM00966 SpoVT_AbrB # SUBUNIT MAZE_ECOLI Probably forms a homodimer in the absence of MazF; binds DNA as a homodimer (PubMed 25564525, PubMed 12533537). Forms a heterohexamer composed of alternating toxin and antitoxin homodimers MazF(2)-MazE(2)-MazF(2). {ECO 0000269|PubMed 11071896, ECO 0000269|PubMed 12533537, ECO 0000269|PubMed 12718874, ECO 0000269|PubMed 12743116, ECO 0000269|PubMed 25564525, ECO 0000269|PubMed 8650219}. # eggNOG COG2336 LUCA # eggNOG ENOG4106A2Z Bacteria BLAST swissprot:MAZE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MAZE_ECOLI BioCyc ECOL316407:JW2754-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2754-MONOMER BioCyc EcoCyc:EG10571-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10571-MONOMER BioCyc MetaCyc:EG10571-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10571-MONOMER COG COG2336 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2336 DOI 10.1007/s00438-004-1048-y http://dx.doi.org/10.1007/s00438-004-1048-y DOI 10.1016/S0022-2836(03)00922-7 http://dx.doi.org/10.1016/S0022-2836(03)00922-7 DOI 10.1016/S0079-6603(08)00812-X http://dx.doi.org/10.1016/S0079-6603(08)00812-X DOI 10.1016/S1097-2765(03)00097-2 http://dx.doi.org/10.1016/S1097-2765(03)00097-2 DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1016/j.molcel.2011.02.023 http://dx.doi.org/10.1016/j.molcel.2011.02.023 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2002.03027.x http://dx.doi.org/10.1046/j.1365-2958.2002.03027.x DOI 10.1073/pnas.93.12.6059 http://dx.doi.org/10.1073/pnas.93.12.6059 DOI 10.1074/jbc.M008832200 http://dx.doi.org/10.1074/jbc.M008832200 DOI 10.1074/jbc.M113.510511 http://dx.doi.org/10.1074/jbc.M113.510511 DOI 10.1074/jbc.M209855200 http://dx.doi.org/10.1074/jbc.M209855200 DOI 10.1074/jbc.M302336200 http://dx.doi.org/10.1074/jbc.M302336200 DOI 10.1093/nar/gku1352 http://dx.doi.org/10.1093/nar/gku1352 DOI 10.1111/j.1365-2958.2005.04956.x http://dx.doi.org/10.1111/j.1365-2958.2005.04956.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.186.24.8295-8300.2004 http://dx.doi.org/10.1128/JB.186.24.8295-8300.2004 DOI 10.1186/1471-2180-13-45 http://dx.doi.org/10.1186/1471-2180-13-45 DOI 10.1371/journal.pone.0006785 http://dx.doi.org/10.1371/journal.pone.0006785 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D16450 http://www.ebi.ac.uk/ena/data/view/D16450 EMBL J04039 http://www.ebi.ac.uk/ena/data/view/J04039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29580 http://www.ebi.ac.uk/ena/data/view/U29580 EchoBASE EB0566 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0566 EcoGene EG10571 http://www.ecogene.org/geneInfo.php?eg_id=EG10571 EnsemblBacteria AAC75825 http://www.ensemblgenomes.org/id/AAC75825 EnsemblBacteria AAC75825 http://www.ensemblgenomes.org/id/AAC75825 EnsemblBacteria BAE76857 http://www.ensemblgenomes.org/id/BAE76857 EnsemblBacteria BAE76857 http://www.ensemblgenomes.org/id/BAE76857 EnsemblBacteria BAE76857 http://www.ensemblgenomes.org/id/BAE76857 EnsemblBacteria b2783 http://www.ensemblgenomes.org/id/b2783 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 947245 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947245 HOGENOM HOG000289070 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000289070&db=HOGENOM6 InParanoid P0AE72 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AE72 IntAct P0AE72 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AE72* InterPro IPR007159 http://www.ebi.ac.uk/interpro/entry/IPR007159 KEGG_Gene ecj:JW2754 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2754 KEGG_Gene eco:b2783 http://www.genome.jp/dbget-bin/www_bget?eco:b2783 KEGG_Orthology KO:K07172 http://www.genome.jp/dbget-bin/www_bget?KO:K07172 OMA ISQITPE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ISQITPE PDB 1MVF http://www.ebi.ac.uk/pdbe-srv/view/entry/1MVF PDB 1UB4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1UB4 PDB 2MRN http://www.ebi.ac.uk/pdbe-srv/view/entry/2MRN PDB 2MRU http://www.ebi.ac.uk/pdbe-srv/view/entry/2MRU PDB 5CQX http://www.ebi.ac.uk/pdbe-srv/view/entry/5CQX PDB 5CQY http://www.ebi.ac.uk/pdbe-srv/view/entry/5CQY PDBsum 1MVF http://www.ebi.ac.uk/pdbsum/1MVF PDBsum 1UB4 http://www.ebi.ac.uk/pdbsum/1UB4 PDBsum 2MRN http://www.ebi.ac.uk/pdbsum/2MRN PDBsum 2MRU http://www.ebi.ac.uk/pdbsum/2MRU PDBsum 5CQX http://www.ebi.ac.uk/pdbsum/5CQX PDBsum 5CQY http://www.ebi.ac.uk/pdbsum/5CQY PROSITE PS51740 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51740 PSORT swissprot:MAZE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MAZE_ECOLI PSORT-B swissprot:MAZE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MAZE_ECOLI PSORT2 swissprot:MAZE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MAZE_ECOLI Pfam PF04014 http://pfam.xfam.org/family/PF04014 Phobius swissprot:MAZE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MAZE_ECOLI PhylomeDB P0AE72 http://phylomedb.org/?seqid=P0AE72 ProteinModelPortal P0AE72 http://www.proteinmodelportal.org/query/uniprot/P0AE72 PubMed 11071896 http://www.ncbi.nlm.nih.gov/pubmed/11071896 PubMed 12123459 http://www.ncbi.nlm.nih.gov/pubmed/12123459 PubMed 12533537 http://www.ncbi.nlm.nih.gov/pubmed/12533537 PubMed 12718874 http://www.ncbi.nlm.nih.gov/pubmed/12718874 PubMed 12743116 http://www.ncbi.nlm.nih.gov/pubmed/12743116 PubMed 12972253 http://www.ncbi.nlm.nih.gov/pubmed/12972253 PubMed 15316771 http://www.ncbi.nlm.nih.gov/pubmed/15316771 PubMed 15576778 http://www.ncbi.nlm.nih.gov/pubmed/15576778 PubMed 16390452 http://www.ncbi.nlm.nih.gov/pubmed/16390452 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19215780 http://www.ncbi.nlm.nih.gov/pubmed/19215780 PubMed 19707553 http://www.ncbi.nlm.nih.gov/pubmed/19707553 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 21419338 http://www.ncbi.nlm.nih.gov/pubmed/21419338 PubMed 23432955 http://www.ncbi.nlm.nih.gov/pubmed/23432955 PubMed 24375411 http://www.ncbi.nlm.nih.gov/pubmed/24375411 PubMed 25564525 http://www.ncbi.nlm.nih.gov/pubmed/25564525 PubMed 2844820 http://www.ncbi.nlm.nih.gov/pubmed/2844820 PubMed 8226627 http://www.ncbi.nlm.nih.gov/pubmed/8226627 PubMed 8650219 http://www.ncbi.nlm.nih.gov/pubmed/8650219 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417263 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417263 RefSeq WP_000581937 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000581937 SMART SM00966 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00966 SMR P0AE72 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AE72 STRING 511145.b2783 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2783&targetmode=cogs STRING COG2336 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2336&targetmode=cogs UniProtKB MAZE_ECOLI http://www.uniprot.org/uniprot/MAZE_ECOLI UniProtKB-AC P0AE72 http://www.uniprot.org/uniprot/P0AE72 charge swissprot:MAZE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MAZE_ECOLI eggNOG COG2336 http://eggnogapi.embl.de/nog_data/html/tree/COG2336 eggNOG ENOG4106A2Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106A2Z epestfind swissprot:MAZE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MAZE_ECOLI garnier swissprot:MAZE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MAZE_ECOLI helixturnhelix swissprot:MAZE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MAZE_ECOLI hmoment swissprot:MAZE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MAZE_ECOLI iep swissprot:MAZE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MAZE_ECOLI inforesidue swissprot:MAZE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MAZE_ECOLI octanol swissprot:MAZE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MAZE_ECOLI pepcoil swissprot:MAZE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MAZE_ECOLI pepdigest swissprot:MAZE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MAZE_ECOLI pepinfo swissprot:MAZE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MAZE_ECOLI pepnet swissprot:MAZE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MAZE_ECOLI pepstats swissprot:MAZE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MAZE_ECOLI pepwheel swissprot:MAZE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MAZE_ECOLI pepwindow swissprot:MAZE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MAZE_ECOLI sigcleave swissprot:MAZE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MAZE_ECOLI ## Database ID URL or Descriptions # BioGrid 4259525 8 # EcoGene EG11918 zraP # FUNCTION ZRAP_ECOLI Binds zinc. Could be an important component of the zinc- balancing mechanism. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0043167 ion binding # InterPro IPR020365 Zn_resistance-assoc_prot_ZraP # InterPro IPR025961 Metal_resist # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko02020 Two-component system # Organism ZRAP_ECOLI Escherichia coli (strain K12) # PATRIC 32123527 VBIEscCol129921_4116 # PIR E65207 E65207 # Pfam PF13801 Metal_resist # ProDom PD097062 Zn_resistance-assoc_prot_ZraP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ZRAP_ECOLI Zinc resistance-associated protein # RefSeq NP_418430 NC_000913.3 # RefSeq WP_000828222 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAC43100.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ZraP family. {ECO 0000305}. # SUBCELLULAR LOCATION ZRAP_ECOLI Periplasm. # eggNOG COG3678 LUCA # eggNOG ENOG4105JBU Bacteria BLAST swissprot:ZRAP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ZRAP_ECOLI BioCyc ECOL316407:JW5546-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5546-MONOMER BioCyc EcoCyc:EG11918-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11918-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.273.33.21393 http://dx.doi.org/10.1074/jbc.273.33.21393 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1862 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1862 EcoGene EG11918 http://www.ecogene.org/geneInfo.php?eg_id=EG11918 EnsemblBacteria AAC76976 http://www.ensemblgenomes.org/id/AAC76976 EnsemblBacteria AAC76976 http://www.ensemblgenomes.org/id/AAC76976 EnsemblBacteria BAE77317 http://www.ensemblgenomes.org/id/BAE77317 EnsemblBacteria BAE77317 http://www.ensemblgenomes.org/id/BAE77317 EnsemblBacteria BAE77317 http://www.ensemblgenomes.org/id/BAE77317 EnsemblBacteria b4002 http://www.ensemblgenomes.org/id/b4002 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GeneID 948507 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948507 HOGENOM HOG000126776 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126776&db=HOGENOM6 InterPro IPR020365 http://www.ebi.ac.uk/interpro/entry/IPR020365 InterPro IPR025961 http://www.ebi.ac.uk/interpro/entry/IPR025961 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW5546 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5546 KEGG_Gene eco:b4002 http://www.genome.jp/dbget-bin/www_bget?eco:b4002 KEGG_Orthology KO:K07803 http://www.genome.jp/dbget-bin/www_bget?KO:K07803 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA GMGYGDC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GMGYGDC PSORT swissprot:ZRAP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ZRAP_ECOLI PSORT-B swissprot:ZRAP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ZRAP_ECOLI PSORT2 swissprot:ZRAP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ZRAP_ECOLI Pfam PF13801 http://pfam.xfam.org/family/PF13801 Phobius swissprot:ZRAP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ZRAP_ECOLI ProteinModelPortal P0AAA9 http://www.proteinmodelportal.org/query/uniprot/P0AAA9 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9694902 http://www.ncbi.nlm.nih.gov/pubmed/9694902 RefSeq NP_418430 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418430 RefSeq WP_000828222 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000828222 SMR P0AAA9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAA9 STRING 511145.b4002 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4002&targetmode=cogs UniProtKB ZRAP_ECOLI http://www.uniprot.org/uniprot/ZRAP_ECOLI UniProtKB-AC P0AAA9 http://www.uniprot.org/uniprot/P0AAA9 charge swissprot:ZRAP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ZRAP_ECOLI eggNOG COG3678 http://eggnogapi.embl.de/nog_data/html/tree/COG3678 eggNOG ENOG4105JBU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105JBU epestfind swissprot:ZRAP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ZRAP_ECOLI garnier swissprot:ZRAP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ZRAP_ECOLI helixturnhelix swissprot:ZRAP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ZRAP_ECOLI hmoment swissprot:ZRAP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ZRAP_ECOLI iep swissprot:ZRAP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ZRAP_ECOLI inforesidue swissprot:ZRAP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ZRAP_ECOLI octanol swissprot:ZRAP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ZRAP_ECOLI pepcoil swissprot:ZRAP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ZRAP_ECOLI pepdigest swissprot:ZRAP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ZRAP_ECOLI pepinfo swissprot:ZRAP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ZRAP_ECOLI pepnet swissprot:ZRAP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ZRAP_ECOLI pepstats swissprot:ZRAP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ZRAP_ECOLI pepwheel swissprot:ZRAP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ZRAP_ECOLI pepwindow swissprot:ZRAP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ZRAP_ECOLI sigcleave swissprot:ZRAP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ZRAP_ECOLI ## Database ID URL or Descriptions # BioGrid 4259943 6 # COFACTOR Name=heme; Xref=ChEBI:CHEBI 30413; Note=The heme is bound between the two transmembrane subunits.; # EcoGene EG10934 sdhD # FUNCTION DHSD_ECOLI Membrane-anchoring subunit of succinate dehydrogenase (SDH). # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0000104 succinate dehydrogenase activity; IEA:InterPro. # GO_function GO:0009055 electron carrier activity; IDA:EcoCyc. # GO_function GO:0020037 heme binding; IMP:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006099 tricarboxylic acid cycle; IEA:UniProtKB-UniPathway. # GO_process GO:0009060 aerobic respiration; IEP:EcoCyc. # GO_process GO:0017004 cytochrome complex assembly; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0044281 small molecule metabolic process # InterPro IPR000701 Succ_DH_Fumarate_Rdtase_TM-su # InterPro IPR014312 Succ_DH_anchor # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Pathway ko00020 Citrate cycle (TCA cycle) # KEGG_Pathway ko00190 Oxidative phosphorylation # KEGG_Pathway ko00623 Toluene degradation # KEGG_Pathway ko00650 Butanoate metabolism # KEGG_Pathway ko00720 Carbon fixation pathways in prokaryotes # Organism DHSD_ECOLI Escherichia coli (strain K12) # PATHWAY DHSD_ECOLI Carbohydrate metabolism; tricarboxylic acid cycle. # PATRIC 32116639 VBIEscCol129921_0752 # PDB 1NEK X-ray; 2.60 A; D=1-115 # PDB 1NEN X-ray; 2.90 A; D=1-115 # PDB 2ACZ X-ray; 3.10 A; D=1-115 # PDB 2AD0 Model; -; D=1-115 # PDB 2WDQ X-ray; 2.40 A; D/H/L=1-115 # PDB 2WDR X-ray; 3.20 A; D/H/L=1-115 # PDB 2WDV X-ray; 3.20 A; D/H/L=1-115 # PDB 2WP9 X-ray; 2.70 A; D/H/L=1-115 # PDB 2WS3 X-ray; 3.20 A; D/H/L=1-115 # PDB 2WU2 X-ray; 2.50 A; D/H/L=1-115 # PDB 2WU5 X-ray; 2.80 A; D/H/L=1-115 # PIR B28836 DEECS2 # PIRSF PIRSF000169 SDH_D # Pfam PF01127 Sdh_cyt # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DHSD_ECOLI Succinate dehydrogenase hydrophobic membrane anchor subunit # RefSeq NP_415250 NC_000913.3 # RefSeq WP_000254365 NZ_LN832404.1 # SUBCELLULAR LOCATION DHSD_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # SUBUNIT DHSD_ECOLI Part of an enzyme complex containing four subunits a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD. The complex can form homotrimers. {ECO 0000269|PubMed 12560550, ECO 0000269|PubMed 16407191, ECO 0000269|PubMed 19710024}. # TIGRFAMs TIGR02968 succ_dehyd_anc # eggNOG COG2142 LUCA # eggNOG ENOG4105N1I Bacteria BLAST swissprot:DHSD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DHSD_ECOLI BioCyc ECOL316407:JW0712-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0712-MONOMER BioCyc EcoCyc:SDH-MEMB2 http://biocyc.org/getid?id=EcoCyc:SDH-MEMB2 BioCyc MetaCyc:SDH-MEMB2 http://biocyc.org/getid?id=MetaCyc:SDH-MEMB2 COG COG2142 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2142 DIP DIP-10838N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10838N DOI 10.1021/bi9716635 http://dx.doi.org/10.1021/bi9716635 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2220519 http://dx.doi.org/10.1042/bj2220519 DOI 10.1074/jbc.M109.010058 http://dx.doi.org/10.1074/jbc.M109.010058 DOI 10.1074/jbc.M508173200 http://dx.doi.org/10.1074/jbc.M508173200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1079605 http://dx.doi.org/10.1126/science.1079605 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01619 http://www.ebi.ac.uk/ena/data/view/J01619 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X00980 http://www.ebi.ac.uk/ena/data/view/X00980 EchoBASE EB0927 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0927 EcoGene EG10934 http://www.ecogene.org/geneInfo.php?eg_id=EG10934 EnsemblBacteria AAC73816 http://www.ensemblgenomes.org/id/AAC73816 EnsemblBacteria AAC73816 http://www.ensemblgenomes.org/id/AAC73816 EnsemblBacteria BAA35389 http://www.ensemblgenomes.org/id/BAA35389 EnsemblBacteria BAA35389 http://www.ensemblgenomes.org/id/BAA35389 EnsemblBacteria BAA35389 http://www.ensemblgenomes.org/id/BAA35389 EnsemblBacteria b0722 http://www.ensemblgenomes.org/id/b0722 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0000104 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000104 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0020037 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0020037 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006099 GO_process GO:0009060 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009060 GO_process GO:0017004 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017004 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 945322 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945322 HOGENOM HOG000160364 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000160364&db=HOGENOM6 InParanoid P0AC44 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AC44 IntAct P0AC44 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AC44* InterPro IPR000701 http://www.ebi.ac.uk/interpro/entry/IPR000701 InterPro IPR014312 http://www.ebi.ac.uk/interpro/entry/IPR014312 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Gene ecj:JW0712 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0712 KEGG_Gene eco:b0722 http://www.genome.jp/dbget-bin/www_bget?eco:b0722 KEGG_Orthology KO:K00242 http://www.genome.jp/dbget-bin/www_bget?KO:K00242 KEGG_Pathway ko00020 http://www.genome.jp/kegg-bin/show_pathway?ko00020 KEGG_Pathway ko00190 http://www.genome.jp/kegg-bin/show_pathway?ko00190 KEGG_Pathway ko00623 http://www.genome.jp/kegg-bin/show_pathway?ko00623 KEGG_Pathway ko00650 http://www.genome.jp/kegg-bin/show_pathway?ko00650 KEGG_Pathway ko00720 http://www.genome.jp/kegg-bin/show_pathway?ko00720 KEGG_Reaction rn:R00408 http://www.genome.jp/dbget-bin/www_bget?rn:R00408 KEGG_Reaction rn:R00412 http://www.genome.jp/dbget-bin/www_bget?rn:R00412 OMA QWMKVLT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QWMKVLT PDB 1NEK http://www.ebi.ac.uk/pdbe-srv/view/entry/1NEK PDB 1NEN http://www.ebi.ac.uk/pdbe-srv/view/entry/1NEN PDB 2ACZ http://www.ebi.ac.uk/pdbe-srv/view/entry/2ACZ PDB 2AD0 http://www.ebi.ac.uk/pdbe-srv/view/entry/2AD0 PDB 2WDQ http://www.ebi.ac.uk/pdbe-srv/view/entry/2WDQ PDB 2WDR http://www.ebi.ac.uk/pdbe-srv/view/entry/2WDR PDB 2WDV http://www.ebi.ac.uk/pdbe-srv/view/entry/2WDV PDB 2WP9 http://www.ebi.ac.uk/pdbe-srv/view/entry/2WP9 PDB 2WS3 http://www.ebi.ac.uk/pdbe-srv/view/entry/2WS3 PDB 2WU2 http://www.ebi.ac.uk/pdbe-srv/view/entry/2WU2 PDB 2WU5 http://www.ebi.ac.uk/pdbe-srv/view/entry/2WU5 PDBsum 1NEK http://www.ebi.ac.uk/pdbsum/1NEK PDBsum 1NEN http://www.ebi.ac.uk/pdbsum/1NEN PDBsum 2ACZ http://www.ebi.ac.uk/pdbsum/2ACZ PDBsum 2AD0 http://www.ebi.ac.uk/pdbsum/2AD0 PDBsum 2WDQ http://www.ebi.ac.uk/pdbsum/2WDQ PDBsum 2WDR http://www.ebi.ac.uk/pdbsum/2WDR PDBsum 2WDV http://www.ebi.ac.uk/pdbsum/2WDV PDBsum 2WP9 http://www.ebi.ac.uk/pdbsum/2WP9 PDBsum 2WS3 http://www.ebi.ac.uk/pdbsum/2WS3 PDBsum 2WU2 http://www.ebi.ac.uk/pdbsum/2WU2 PDBsum 2WU5 http://www.ebi.ac.uk/pdbsum/2WU5 PSORT swissprot:DHSD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DHSD_ECOLI PSORT-B swissprot:DHSD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DHSD_ECOLI PSORT2 swissprot:DHSD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DHSD_ECOLI Pfam PF01127 http://pfam.xfam.org/family/PF01127 Phobius swissprot:DHSD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DHSD_ECOLI PhylomeDB P0AC44 http://phylomedb.org/?seqid=P0AC44 ProteinModelPortal P0AC44 http://www.proteinmodelportal.org/query/uniprot/P0AC44 PubMed 12560550 http://www.ncbi.nlm.nih.gov/pubmed/12560550 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16407191 http://www.ncbi.nlm.nih.gov/pubmed/16407191 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19710024 http://www.ncbi.nlm.nih.gov/pubmed/19710024 PubMed 6383359 http://www.ncbi.nlm.nih.gov/pubmed/6383359 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9521736 http://www.ncbi.nlm.nih.gov/pubmed/9521736 RefSeq NP_415250 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415250 RefSeq WP_000254365 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000254365 SMR P0AC44 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AC44 STRING 511145.b0722 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0722&targetmode=cogs STRING COG2142 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2142&targetmode=cogs TIGRFAMs TIGR02968 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02968 UniProtKB DHSD_ECOLI http://www.uniprot.org/uniprot/DHSD_ECOLI UniProtKB-AC P0AC44 http://www.uniprot.org/uniprot/P0AC44 charge swissprot:DHSD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DHSD_ECOLI eggNOG COG2142 http://eggnogapi.embl.de/nog_data/html/tree/COG2142 eggNOG ENOG4105N1I http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105N1I epestfind swissprot:DHSD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DHSD_ECOLI garnier swissprot:DHSD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DHSD_ECOLI helixturnhelix swissprot:DHSD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DHSD_ECOLI hmoment swissprot:DHSD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DHSD_ECOLI iep swissprot:DHSD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DHSD_ECOLI inforesidue swissprot:DHSD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DHSD_ECOLI octanol swissprot:DHSD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DHSD_ECOLI pepcoil swissprot:DHSD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DHSD_ECOLI pepdigest swissprot:DHSD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DHSD_ECOLI pepinfo swissprot:DHSD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DHSD_ECOLI pepnet swissprot:DHSD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DHSD_ECOLI pepstats swissprot:DHSD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DHSD_ECOLI pepwheel swissprot:DHSD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DHSD_ECOLI pepwindow swissprot:DHSD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DHSD_ECOLI sigcleave swissprot:DHSD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DHSD_ECOLI ## Database ID URL or Descriptions # BioGrid 4259599 406 # CATALYTIC ACTIVITY 3-hydroxyadipyl-CoA + NAD(+) = 3-oxoadipyl-CoA + NADH. {ECO:0000269|PubMed 20660314}. # DISRUPTION PHENOTYPE Mutants accumulate 3-hydroxyadipate and are unable to use phenylacetate as a carbon source. {ECO:0000269|PubMed 12846838}. # EcoGene EG13742 paaH # FUNCTION PAAH_ECOLI Catalyzes the oxidation of 3-hydroxyadipyl-CoA to yield 3-oxoadipyl-CoA. {ECO 0000269|PubMed 20660314, ECO 0000269|PubMed 9748275}. # GO_function GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity; IDA:EcoCyc. # GO_function GO:0008691 3-hydroxybutyryl-CoA dehydrogenase activity; IDA:UniProtKB. # GO_process GO:0006631 fatty acid metabolic process; IEA:InterPro. # GO_process GO:0010124 phenylacetate catabolic process; IMP:UniProtKB. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.1040.10 -; 2. # Gene3D 3.40.50.720 -; 1. # INDUCTION PAAH_ECOLI Activated by cAMP receptor protein (CRP), integration host factor (IHF) and by phenylacetyl-coenzyme A (PA-CoA) that prevents PaaX from binding its target sequences. Inhibited by PaaX. {ECO 0000269|PubMed 10766858, ECO 0000269|PubMed 9748275}. # InterPro IPR006108 3HC_DH_C # InterPro IPR006176 3-OHacyl-CoA_DH_NAD-bd # InterPro IPR006180 3-OHacyl-CoA_DH_CS # InterPro IPR008927 6-PGluconate_DH_C-like # InterPro IPR011967 3-OHacyl-CoA_DH_PaaC # InterPro IPR013328 6PGD_dom_2 # InterPro IPR016040 NAD(P)-bd_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00360 Phenylalanine metabolism # KEGG_Pathway ko00362 Benzoate degradation # KEGG_Pathway ko00650 Butanoate metabolism # Organism PAAH_ECOLI Escherichia coli (strain K12) # PATHWAY PAAH_ECOLI Aromatic compound metabolism; phenylacetate degradation. # PATRIC 32118076 VBIEscCol129921_1458 # PDB 3MOG X-ray; 2.20 A; A/B/C=4-475 # PIR F64890 F64890 # PROSITE PS00067 3HCDH # Pfam PF00725 3HCDH; 2 # Pfam PF02737 3HCDH_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PAAH_ECOLI 3-hydroxyadipyl-CoA dehydrogenase # RefSeq NP_415913 NC_000913.3 # RefSeq WP_000973360 NZ_LN832404.1 # SIMILARITY Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. {ECO 0000305}. # SUBUNIT Homotrimer. {ECO 0000305}. # SUPFAM SSF48179 SSF48179; 2 # SUPFAM SSF51735 SSF51735 # TIGRFAMs TIGR02279 PaaC-3OHAcCoADH # eggNOG COG1250 LUCA # eggNOG ENOG4105DYT Bacteria BLAST swissprot:PAAH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PAAH_ECOLI BioCyc ECOL316407:JW1390-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1390-MONOMER BioCyc EcoCyc:G6716-MONOMER http://biocyc.org/getid?id=EcoCyc:G6716-MONOMER BioCyc MetaCyc:G6716-MONOMER http://biocyc.org/getid?id=MetaCyc:G6716-MONOMER COG COG1250 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1250 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1432-1033.2003.03683.x http://dx.doi.org/10.1046/j.1432-1033.2003.03683.x DOI 10.1073/pnas.1005399107 http://dx.doi.org/10.1073/pnas.1005399107 DOI 10.1074/jbc.273.40.25974 http://dx.doi.org/10.1074/jbc.273.40.25974 DOI 10.1074/jbc.275.16.12214 http://dx.doi.org/10.1074/jbc.275.16.12214 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.- http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X97452 http://www.ebi.ac.uk/ena/data/view/X97452 ENZYME 1.1.1.- http://enzyme.expasy.org/EC/1.1.1.- EchoBASE EB3505 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3505 EcoGene EG13742 http://www.ecogene.org/geneInfo.php?eg_id=EG13742 EnsemblBacteria AAC74477 http://www.ensemblgenomes.org/id/AAC74477 EnsemblBacteria AAC74477 http://www.ensemblgenomes.org/id/AAC74477 EnsemblBacteria BAA15001 http://www.ensemblgenomes.org/id/BAA15001 EnsemblBacteria BAA15001 http://www.ensemblgenomes.org/id/BAA15001 EnsemblBacteria BAA15001 http://www.ensemblgenomes.org/id/BAA15001 EnsemblBacteria b1395 http://www.ensemblgenomes.org/id/b1395 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003857 GO_function GO:0008691 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008691 GO_process GO:0006631 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006631 GO_process GO:0010124 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010124 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.1040.10 http://www.cathdb.info/version/latest/superfamily/1.10.1040.10 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 945940 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945940 HOGENOM HOG000141500 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000141500&db=HOGENOM6 InParanoid P76083 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76083 IntAct P76083 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76083* IntEnz 1.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1 InterPro IPR006108 http://www.ebi.ac.uk/interpro/entry/IPR006108 InterPro IPR006176 http://www.ebi.ac.uk/interpro/entry/IPR006176 InterPro IPR006180 http://www.ebi.ac.uk/interpro/entry/IPR006180 InterPro IPR008927 http://www.ebi.ac.uk/interpro/entry/IPR008927 InterPro IPR011967 http://www.ebi.ac.uk/interpro/entry/IPR011967 InterPro IPR013328 http://www.ebi.ac.uk/interpro/entry/IPR013328 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1390 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1390 KEGG_Gene eco:b1395 http://www.genome.jp/dbget-bin/www_bget?eco:b1395 KEGG_Orthology KO:K00074 http://www.genome.jp/dbget-bin/www_bget?KO:K00074 KEGG_Pathway ko00360 http://www.genome.jp/kegg-bin/show_pathway?ko00360 KEGG_Pathway ko00362 http://www.genome.jp/kegg-bin/show_pathway?ko00362 KEGG_Pathway ko00650 http://www.genome.jp/kegg-bin/show_pathway?ko00650 KEGG_Reaction rn:R01976 http://www.genome.jp/dbget-bin/www_bget?rn:R01976 KEGG_Reaction rn:R05576 http://www.genome.jp/dbget-bin/www_bget?rn:R05576 KEGG_Reaction rn:R06941 http://www.genome.jp/dbget-bin/www_bget?rn:R06941 OMA GQKQVPA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GQKQVPA PDB 3MOG http://www.ebi.ac.uk/pdbe-srv/view/entry/3MOG PDBsum 3MOG http://www.ebi.ac.uk/pdbsum/3MOG PROSITE PS00067 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00067 PSORT swissprot:PAAH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PAAH_ECOLI PSORT-B swissprot:PAAH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PAAH_ECOLI PSORT2 swissprot:PAAH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PAAH_ECOLI Pfam PF00725 http://pfam.xfam.org/family/PF00725 Pfam PF02737 http://pfam.xfam.org/family/PF02737 Phobius swissprot:PAAH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PAAH_ECOLI PhylomeDB P76083 http://phylomedb.org/?seqid=P76083 ProteinModelPortal P76083 http://www.proteinmodelportal.org/query/uniprot/P76083 PubMed 10766858 http://www.ncbi.nlm.nih.gov/pubmed/10766858 PubMed 12846838 http://www.ncbi.nlm.nih.gov/pubmed/12846838 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20660314 http://www.ncbi.nlm.nih.gov/pubmed/20660314 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9748275 http://www.ncbi.nlm.nih.gov/pubmed/9748275 RefSeq NP_415913 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415913 RefSeq WP_000973360 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000973360 SMR P76083 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76083 STRING 511145.b1395 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1395&targetmode=cogs STRING COG1250 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1250&targetmode=cogs SUPFAM SSF48179 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48179 SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 TIGRFAMs TIGR02279 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02279 UniProtKB PAAH_ECOLI http://www.uniprot.org/uniprot/PAAH_ECOLI UniProtKB-AC P76083 http://www.uniprot.org/uniprot/P76083 charge swissprot:PAAH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PAAH_ECOLI eggNOG COG1250 http://eggnogapi.embl.de/nog_data/html/tree/COG1250 eggNOG ENOG4105DYT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DYT epestfind swissprot:PAAH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PAAH_ECOLI garnier swissprot:PAAH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PAAH_ECOLI helixturnhelix swissprot:PAAH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PAAH_ECOLI hmoment swissprot:PAAH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PAAH_ECOLI iep swissprot:PAAH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PAAH_ECOLI inforesidue swissprot:PAAH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PAAH_ECOLI octanol swissprot:PAAH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PAAH_ECOLI pepcoil swissprot:PAAH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PAAH_ECOLI pepdigest swissprot:PAAH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PAAH_ECOLI pepinfo swissprot:PAAH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PAAH_ECOLI pepnet swissprot:PAAH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PAAH_ECOLI pepstats swissprot:PAAH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PAAH_ECOLI pepwheel swissprot:PAAH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PAAH_ECOLI pepwindow swissprot:PAAH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PAAH_ECOLI sigcleave swissprot:PAAH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PAAH_ECOLI ## Database ID URL or Descriptions # EcoGene EG14351 yciX # Organism YCIX_ECOLI Escherichia coli (strain K12) # PATRIC 32117812 VBIEscCol129921_1326 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCIX_ECOLI Uncharacterized protein YciX # RefSeq WP_001297116 NZ_LN832404.1 # RefSeq YP_588450 NC_000913.3 BLAST swissprot:YCIX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCIX_ECOLI BioCyc EcoCyc:MONOMER0-2886 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2886 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14351 http://www.ecogene.org/geneInfo.php?eg_id=EG14351 EnsemblBacteria ABD18656 http://www.ensemblgenomes.org/id/ABD18656 EnsemblBacteria ABD18656 http://www.ensemblgenomes.org/id/ABD18656 EnsemblBacteria b4523 http://www.ensemblgenomes.org/id/b4523 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1450257 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1450257 HOGENOM HOG000267927 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267927&db=HOGENOM6 InParanoid P58094 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P58094 KEGG_Gene eco:b4523 http://www.genome.jp/dbget-bin/www_bget?eco:b4523 OMA WQLTTQQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WQLTTQQ PSORT swissprot:YCIX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCIX_ECOLI PSORT-B swissprot:YCIX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCIX_ECOLI PSORT2 swissprot:YCIX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCIX_ECOLI Phobius swissprot:YCIX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCIX_ECOLI PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001297116 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001297116 RefSeq YP_588450 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_588450 STRING 511145.b4523 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4523&targetmode=cogs UniProtKB YCIX_ECOLI http://www.uniprot.org/uniprot/YCIX_ECOLI UniProtKB-AC P58094 http://www.uniprot.org/uniprot/P58094 charge swissprot:YCIX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCIX_ECOLI epestfind swissprot:YCIX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCIX_ECOLI garnier swissprot:YCIX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCIX_ECOLI helixturnhelix swissprot:YCIX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCIX_ECOLI hmoment swissprot:YCIX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCIX_ECOLI iep swissprot:YCIX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCIX_ECOLI inforesidue swissprot:YCIX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCIX_ECOLI octanol swissprot:YCIX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCIX_ECOLI pepcoil swissprot:YCIX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCIX_ECOLI pepdigest swissprot:YCIX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCIX_ECOLI pepinfo swissprot:YCIX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCIX_ECOLI pepnet swissprot:YCIX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCIX_ECOLI pepstats swissprot:YCIX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCIX_ECOLI pepwheel swissprot:YCIX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCIX_ECOLI pepwindow swissprot:YCIX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCIX_ECOLI sigcleave swissprot:YCIX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCIX_ECOLI ## Database ID URL or Descriptions # CAUTION Could be the product of a pseudogene. A frameshift in position 142 produces two separate ORFs. {ECO 0000305}. # EcoGene EG13983 arpB # Gene3D 1.25.40.20 -; 1. # IntAct P76205 2 # InterPro IPR012927 Toxin_15_N # InterPro IPR020683 Ankyrin_rpt-contain_dom # Organism ARPB_ECOLI Escherichia coli (strain K12) # Pfam PF07906 Toxin_15 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ARPB_ECOLI Putative ankyrin repeat protein B # SEQUENCE CAUTION Sequence=AP009048; Type=Frameshift; Positions=142; Evidence={ECO:0000305}; Sequence=U00096; Type=Frameshift; Positions=142; Evidence={ECO 0000305}; # SIMILARITY Contains 3 ANK repeats. {ECO 0000305}. # SUPFAM SSF48403 SSF48403 BLAST swissprot:ARPB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARPB_ECOLI BioCyc EcoCyc:G6926-MONOMER http://biocyc.org/getid?id=EcoCyc:G6926-MONOMER BioCyc EcoCyc:G6927-MONOMER http://biocyc.org/getid?id=EcoCyc:G6927-MONOMER DIP DIP-9160N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9160N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3739 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3739 EcoGene EG13983 http://www.ecogene.org/geneInfo.php?eg_id=EG13983 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 1.25.40.20 http://www.cathdb.info/version/latest/superfamily/1.25.40.20 HOGENOM HOG000051632 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000051632&db=HOGENOM6 InParanoid P76205 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76205 IntAct P76205 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76205* InterPro IPR012927 http://www.ebi.ac.uk/interpro/entry/IPR012927 InterPro IPR020683 http://www.ebi.ac.uk/interpro/entry/IPR020683 PSORT swissprot:ARPB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARPB_ECOLI PSORT-B swissprot:ARPB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARPB_ECOLI PSORT2 swissprot:ARPB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARPB_ECOLI Pfam PF07906 http://pfam.xfam.org/family/PF07906 Phobius swissprot:ARPB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARPB_ECOLI ProteinModelPortal P76205 http://www.proteinmodelportal.org/query/uniprot/P76205 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SUPFAM SSF48403 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48403 UniProtKB ARPB_ECOLI http://www.uniprot.org/uniprot/ARPB_ECOLI UniProtKB-AC P76205 http://www.uniprot.org/uniprot/P76205 charge swissprot:ARPB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARPB_ECOLI epestfind swissprot:ARPB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARPB_ECOLI garnier swissprot:ARPB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARPB_ECOLI helixturnhelix swissprot:ARPB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARPB_ECOLI hmoment swissprot:ARPB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARPB_ECOLI iep swissprot:ARPB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARPB_ECOLI inforesidue swissprot:ARPB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARPB_ECOLI octanol swissprot:ARPB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARPB_ECOLI pepcoil swissprot:ARPB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARPB_ECOLI pepdigest swissprot:ARPB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARPB_ECOLI pepinfo swissprot:ARPB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARPB_ECOLI pepnet swissprot:ARPB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARPB_ECOLI pepstats swissprot:ARPB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARPB_ECOLI pepwheel swissprot:ARPB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARPB_ECOLI pepwindow swissprot:ARPB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARPB_ECOLI sigcleave swissprot:ARPB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARPB_ECOLI ## Database ID URL or Descriptions # CATALYTIC ACTIVITY ARAB_ECOLI ATP + L(or D)-ribulose = ADP + L(or D)- ribulose 5-phosphate. # CDD cd07781 FGGY_RBK # EcoGene EG10053 araB # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0008741 ribulokinase activity; IDA:EcoCyc. # GO_function GO:0016773 phosphotransferase activity, alcohol group as acceptor; IDA:EcoliWiki. # GO_process GO:0016052 carbohydrate catabolic process; IDA:EcoliWiki. # GO_process GO:0019568 arabinose catabolic process; IDA:EcoliWiki. # GO_process GO:0019569 L-arabinose catabolic process to xylulose 5-phosphate; IEP:EcoCyc. # GO_process GO:0019572 L-arabinose catabolic process; IDA:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # HAMAP MF_00520 Ribulokinase # InterPro IPR005929 Ribulokinase # InterPro IPR018485 Carb_kinase_FGGY_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00040 Pentose and glucuronate interconversions # Organism ARAB_ECOLI Escherichia coli (strain K12) # PATHWAY Carbohydrate degradation; L-arabinose degradation via L- ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route) step 2/3. # PATRIC 32115227 VBIEscCol129921_0065 # PIR G64727 KIECRU # Pfam PF02782 FGGY_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ARAB_ECOLI Ribulokinase # RefSeq NP_414605 NC_000913.3 # RefSeq WP_000951856 NZ_LN832404.1 # SIMILARITY Belongs to the ribulokinase family. {ECO 0000305}. # TIGRFAMs TIGR01234 L-ribulokinase # UniPathway UPA00145 UER00566 # eggNOG COG1069 LUCA # eggNOG ENOG4105EF1 Bacteria BLAST swissprot:ARAB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARAB_ECOLI BioCyc ECOL316407:JW0062-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0062-MONOMER BioCyc EcoCyc:RIBULOKIN-MONOMER http://biocyc.org/getid?id=EcoCyc:RIBULOKIN-MONOMER BioCyc MetaCyc:RIBULOKIN-MONOMER http://biocyc.org/getid?id=MetaCyc:RIBULOKIN-MONOMER COG COG1069 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1069 DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0378-1119(86)90067-3 http://dx.doi.org/10.1016/0378-1119(86)90067-3 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.74.1.49 http://dx.doi.org/10.1073/pnas.74.1.49 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.16 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.16 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01641 http://www.ebi.ac.uk/ena/data/view/J01641 EMBL K01304 http://www.ebi.ac.uk/ena/data/view/K01304 EMBL M15263 http://www.ebi.ac.uk/ena/data/view/M15263 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.16 http://enzyme.expasy.org/EC/2.7.1.16 EchoBASE EB0051 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0051 EcoGene EG10053 http://www.ecogene.org/geneInfo.php?eg_id=EG10053 EnsemblBacteria AAC73174 http://www.ensemblgenomes.org/id/AAC73174 EnsemblBacteria AAC73174 http://www.ensemblgenomes.org/id/AAC73174 EnsemblBacteria BAB96632 http://www.ensemblgenomes.org/id/BAB96632 EnsemblBacteria BAB96632 http://www.ensemblgenomes.org/id/BAB96632 EnsemblBacteria BAB96632 http://www.ensemblgenomes.org/id/BAB96632 EnsemblBacteria b0063 http://www.ensemblgenomes.org/id/b0063 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008741 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008741 GO_function GO:0016773 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016773 GO_process GO:0016052 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016052 GO_process GO:0019568 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019568 GO_process GO:0019569 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019569 GO_process GO:0019572 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019572 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 946017 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946017 HAMAP MF_00520 http://hamap.expasy.org/unirule/MF_00520 HOGENOM HOG000236883 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000236883&db=HOGENOM6 InParanoid P08204 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P08204 IntAct P08204 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P08204* IntEnz 2.7.1.16 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.16 InterPro IPR005929 http://www.ebi.ac.uk/interpro/entry/IPR005929 InterPro IPR018485 http://www.ebi.ac.uk/interpro/entry/IPR018485 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0062 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0062 KEGG_Gene eco:b0063 http://www.genome.jp/dbget-bin/www_bget?eco:b0063 KEGG_Orthology KO:K00853 http://www.genome.jp/dbget-bin/www_bget?KO:K00853 KEGG_Pathway ko00040 http://www.genome.jp/kegg-bin/show_pathway?ko00040 KEGG_Reaction rn:R01526 http://www.genome.jp/dbget-bin/www_bget?rn:R01526 KEGG_Reaction rn:R02439 http://www.genome.jp/dbget-bin/www_bget?rn:R02439 OMA ACTMLPI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ACTMLPI PSORT swissprot:ARAB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARAB_ECOLI PSORT-B swissprot:ARAB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARAB_ECOLI PSORT2 swissprot:ARAB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARAB_ECOLI Pfam PF02782 http://pfam.xfam.org/family/PF02782 Phobius swissprot:ARAB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARAB_ECOLI PhylomeDB P08204 http://phylomedb.org/?seqid=P08204 ProteinModelPortal P08204 http://www.proteinmodelportal.org/query/uniprot/P08204 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 189315 http://www.ncbi.nlm.nih.gov/pubmed/189315 PubMed 3549454 http://www.ncbi.nlm.nih.gov/pubmed/3549454 PubMed 357433 http://www.ncbi.nlm.nih.gov/pubmed/357433 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_414605 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414605 RefSeq WP_000951856 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000951856 STRING 511145.b0063 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0063&targetmode=cogs STRING COG1069 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1069&targetmode=cogs TIGRFAMs TIGR01234 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01234 UniProtKB ARAB_ECOLI http://www.uniprot.org/uniprot/ARAB_ECOLI UniProtKB-AC P08204 http://www.uniprot.org/uniprot/P08204 charge swissprot:ARAB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARAB_ECOLI eggNOG COG1069 http://eggnogapi.embl.de/nog_data/html/tree/COG1069 eggNOG ENOG4105EF1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EF1 epestfind swissprot:ARAB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARAB_ECOLI garnier swissprot:ARAB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARAB_ECOLI helixturnhelix swissprot:ARAB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARAB_ECOLI hmoment swissprot:ARAB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARAB_ECOLI iep swissprot:ARAB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARAB_ECOLI inforesidue swissprot:ARAB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARAB_ECOLI octanol swissprot:ARAB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARAB_ECOLI pepcoil swissprot:ARAB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARAB_ECOLI pepdigest swissprot:ARAB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARAB_ECOLI pepinfo swissprot:ARAB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARAB_ECOLI pepnet swissprot:ARAB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARAB_ECOLI pepstats swissprot:ARAB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARAB_ECOLI pepwheel swissprot:ARAB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARAB_ECOLI pepwindow swissprot:ARAB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARAB_ECOLI sigcleave swissprot:ARAB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARAB_ECOLI ## Database ID URL or Descriptions # BRENDA 2.2.1 2026 # BioGrid 4262216 8 # CATALYTIC ACTIVITY TKT2_ECOLI Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate. # COFACTOR TKT2_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250}; Name=Ca(2+); Xref=ChEBI CHEBI 29108; Evidence={ECO 0000250}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000250}; Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000250}; Note=Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+). {ECO 0000250}; # COFACTOR TKT2_ECOLI Name=thiamine diphosphate; Xref=ChEBI CHEBI 58937; Evidence={ECO 0000250}; Note=Binds 1 thiamine pyrophosphate per subunit. {ECO 0000250}; # EcoGene EG12100 tktB # FUNCTION TKT2_ECOLI Catalyzes the reversible transfer of a two-carbon ketol group from sedoheptulose-7-phosphate to glyceraldehyde-3- phosphate, producing xylulose-5-phosphate and ribose-5-phosphate. Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate (By similarity). {ECO 0000250}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004802 transketolase activity; IMP:EcoliWiki. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0008152 metabolic process; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.920 -; 1. # Gene3D 3.40.50.970 -; 2. # IntAct P33570 6 # InterPro IPR005474 Transketolase_N # InterPro IPR005475 Transketolase-like_Pyr-bd # InterPro IPR005478 Transketolase_bac-like # InterPro IPR009014 Transketo_C/PFOR_II # InterPro IPR020826 Transketolase_BS # InterPro IPR029061 THDP-binding # InterPro IPR033247 Transketolase_fam # InterPro IPR033248 Transketolase_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00030 Pentose phosphate pathway # KEGG_Pathway ko00710 Carbon fixation in photosynthetic organisms # KEGG_Pathway ko01051 Biosynthesis of ansamycins # Organism TKT2_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11624 PTHR11624; 2 # PATRIC 32120313 VBIEscCol129921_2559 # PIR A48660 A48660 # PROSITE PS00801 TRANSKETOLASE_1 # PROSITE PS00802 TRANSKETOLASE_2 # Pfam PF00456 Transketolase_N # Pfam PF02779 Transket_pyr # Pfam PF02780 Transketolase_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TKT2_ECOLI Transketolase 2 # RefSeq NP_416960 NC_000913.3 # RefSeq WP_000087280 NZ_LN832404.1 # SIMILARITY Belongs to the transketolase family. {ECO 0000305}. # SMART SM00861 Transket_pyr # SUBUNIT Homodimer. {ECO 0000250}. # SUPFAM SSF52518 SSF52518; 2 # SUPFAM SSF52922 SSF52922 # TIGRFAMs TIGR00232 tktlase_bact # eggNOG COG0021 LUCA # eggNOG ENOG4105CV1 Bacteria BLAST swissprot:TKT2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TKT2_ECOLI BioCyc ECOL316407:JW2449-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2449-MONOMER BioCyc EcoCyc:TRANSKETOII-MONOMER http://biocyc.org/getid?id=EcoCyc:TRANSKETOII-MONOMER BioCyc MetaCyc:TRANSKETOII-MONOMER http://biocyc.org/getid?id=MetaCyc:TRANSKETOII-MONOMER COG COG0021 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0021 DIP DIP-10999N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10999N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.2.1.1 http://www.genome.jp/dbget-bin/www_bget?EC:2.2.1.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D12473 http://www.ebi.ac.uk/ena/data/view/D12473 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.2.1.1 http://enzyme.expasy.org/EC/2.2.1.1 EchoBASE EB2024 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2024 EcoGene EG12100 http://www.ecogene.org/geneInfo.php?eg_id=EG12100 EnsemblBacteria AAC75518 http://www.ensemblgenomes.org/id/AAC75518 EnsemblBacteria AAC75518 http://www.ensemblgenomes.org/id/AAC75518 EnsemblBacteria BAA16340 http://www.ensemblgenomes.org/id/BAA16340 EnsemblBacteria BAA16340 http://www.ensemblgenomes.org/id/BAA16340 EnsemblBacteria BAA16340 http://www.ensemblgenomes.org/id/BAA16340 EnsemblBacteria b2465 http://www.ensemblgenomes.org/id/b2465 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004802 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0008152 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008152 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.920 http://www.cathdb.info/version/latest/superfamily/3.40.50.920 Gene3D 3.40.50.970 http://www.cathdb.info/version/latest/superfamily/3.40.50.970 GeneID 945865 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945865 HOGENOM HOG000225953 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000225953&db=HOGENOM6 InParanoid P33570 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33570 IntAct P33570 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33570* IntEnz 2.2.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.2.1.1 InterPro IPR005474 http://www.ebi.ac.uk/interpro/entry/IPR005474 InterPro IPR005475 http://www.ebi.ac.uk/interpro/entry/IPR005475 InterPro IPR005478 http://www.ebi.ac.uk/interpro/entry/IPR005478 InterPro IPR009014 http://www.ebi.ac.uk/interpro/entry/IPR009014 InterPro IPR020826 http://www.ebi.ac.uk/interpro/entry/IPR020826 InterPro IPR029061 http://www.ebi.ac.uk/interpro/entry/IPR029061 InterPro IPR033247 http://www.ebi.ac.uk/interpro/entry/IPR033247 InterPro IPR033248 http://www.ebi.ac.uk/interpro/entry/IPR033248 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2449 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2449 KEGG_Gene eco:b2465 http://www.genome.jp/dbget-bin/www_bget?eco:b2465 KEGG_Orthology KO:K00615 http://www.genome.jp/dbget-bin/www_bget?KO:K00615 KEGG_Pathway ko00030 http://www.genome.jp/kegg-bin/show_pathway?ko00030 KEGG_Pathway ko00710 http://www.genome.jp/kegg-bin/show_pathway?ko00710 KEGG_Pathway ko01051 http://www.genome.jp/kegg-bin/show_pathway?ko01051 KEGG_Reaction rn:R01067 http://www.genome.jp/dbget-bin/www_bget?rn:R01067 KEGG_Reaction rn:R01641 http://www.genome.jp/dbget-bin/www_bget?rn:R01641 KEGG_Reaction rn:R01830 http://www.genome.jp/dbget-bin/www_bget?rn:R01830 KEGG_Reaction rn:R06590 http://www.genome.jp/dbget-bin/www_bget?rn:R06590 OMA GSYKEDV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GSYKEDV PANTHER PTHR11624 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11624 PROSITE PS00801 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00801 PROSITE PS00802 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00802 PSORT swissprot:TKT2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TKT2_ECOLI PSORT-B swissprot:TKT2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TKT2_ECOLI PSORT2 swissprot:TKT2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TKT2_ECOLI Pfam PF00456 http://pfam.xfam.org/family/PF00456 Pfam PF02779 http://pfam.xfam.org/family/PF02779 Pfam PF02780 http://pfam.xfam.org/family/PF02780 Phobius swissprot:TKT2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TKT2_ECOLI PhylomeDB P33570 http://phylomedb.org/?seqid=P33570 ProteinModelPortal P33570 http://www.proteinmodelportal.org/query/uniprot/P33570 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 8396116 http://www.ncbi.nlm.nih.gov/pubmed/8396116 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416960 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416960 RefSeq WP_000087280 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000087280 SMART SM00861 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00861 SMR P33570 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33570 STRING 511145.b2465 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2465&targetmode=cogs STRING COG0021 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0021&targetmode=cogs SUPFAM SSF52518 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52518 SUPFAM SSF52922 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52922 TIGRFAMs TIGR00232 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00232 UniProtKB TKT2_ECOLI http://www.uniprot.org/uniprot/TKT2_ECOLI UniProtKB-AC P33570 http://www.uniprot.org/uniprot/P33570 charge swissprot:TKT2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TKT2_ECOLI eggNOG COG0021 http://eggnogapi.embl.de/nog_data/html/tree/COG0021 eggNOG ENOG4105CV1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CV1 epestfind swissprot:TKT2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TKT2_ECOLI garnier swissprot:TKT2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TKT2_ECOLI helixturnhelix swissprot:TKT2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TKT2_ECOLI hmoment swissprot:TKT2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TKT2_ECOLI iep swissprot:TKT2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TKT2_ECOLI inforesidue swissprot:TKT2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TKT2_ECOLI octanol swissprot:TKT2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TKT2_ECOLI pepcoil swissprot:TKT2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TKT2_ECOLI pepdigest swissprot:TKT2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TKT2_ECOLI pepinfo swissprot:TKT2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TKT2_ECOLI pepnet swissprot:TKT2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TKT2_ECOLI pepstats swissprot:TKT2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TKT2_ECOLI pepwheel swissprot:TKT2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TKT2_ECOLI pepwindow swissprot:TKT2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TKT2_ECOLI sigcleave swissprot:TKT2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TKT2_ECOLI ## Database ID URL or Descriptions # BioGrid 4262330 25 # CATALYTIC ACTIVITY SCPA_ECOLI (R)-methylmalonyl-CoA = succinyl-CoA. {ECO 0000269|PubMed 10769117, ECO 0000269|PubMed 11955068}. # COFACTOR SCPA_ECOLI Name=adenosylcob(III)alamin; Xref=ChEBI CHEBI 18408; Evidence={ECO 0000269|PubMed 10769117, ECO 0000269|PubMed 11955068}; # EcoGene EG11444 scpA # FUNCTION SCPA_ECOLI Catalyzes the interconversion of succinyl-CoA and methylmalonyl-CoA. Could be part of a pathway that converts succinate to propionate. {ECO 0000269|PubMed 10769117, ECO 0000269|PubMed 11955068}. # GO_function GO:0004494 methylmalonyl-CoA mutase activity; IDA:EcoCyc. # GO_function GO:0031419 cobalamin binding; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0008152 metabolic process; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # Gene3D 3.20.20.240 -; 1. # Gene3D 3.40.50.280 -; 1. # IntAct P27253 6 # InterPro IPR006098 MMCoA_mutase_a_cat # InterPro IPR006099 MeMalonylCoA_mutase_a/b_cat # InterPro IPR006158 Cobalamin-bd # InterPro IPR006159 Acid_CoA_mut_C # InterPro IPR014348 Cbl-dep_enz_cat-sub # InterPro IPR016176 Cbl-dep_enz_cat # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00280 Valine, leucine and isoleucine degradation # KEGG_Pathway ko00630 Glyoxylate and dicarboxylate metabolism # KEGG_Pathway ko00640 Propanoate metabolism # KEGG_Pathway ko00720 Carbon fixation pathways in prokaryotes # Organism SCPA_ECOLI Escherichia coli (strain K12) # PATRIC 32121248 VBIEscCol129921_3012 # PIR D65076 D65076 # PROSITE PS00544 METMALONYL_COA_MUTASE # PROSITE PS51332 B12_BINDING # Pfam PF01642 MM_CoA_mutase # Pfam PF02310 B12-binding # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SCPA_ECOLI Methylmalonyl-CoA mutase # RefSeq NP_417392 NC_000913.3 # RefSeq WP_000073223 NZ_LN832404.1 # SIMILARITY Belongs to the methylmalonyl-CoA mutase family. {ECO 0000305}. # SIMILARITY Contains 1 B12-binding domain. {ECO:0000255|PROSITE- ProRule PRU00666}. # SUBUNIT Homodimer. Interacts with ArgK. {ECO:0000269|PubMed 18950999}. # SUPFAM SSF51703 SSF51703 # SUPFAM SSF52242 SSF52242 # TIGRFAMs TIGR00640 acid_CoA_mut_C # TIGRFAMs TIGR00641 acid_CoA_mut_N # eggNOG COG1884 LUCA # eggNOG COG2185 LUCA # eggNOG ENOG4105D5P Bacteria BLAST swissprot:SCPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SCPA_ECOLI BioCyc ECOL316407:JW2884-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2884-MONOMER BioCyc EcoCyc:METHYLMALONYL-COA-MUT-MONOMER http://biocyc.org/getid?id=EcoCyc:METHYLMALONYL-COA-MUT-MONOMER BioCyc MetaCyc:METHYLMALONYL-COA-MUT-MONOMER http://biocyc.org/getid?id=MetaCyc:METHYLMALONYL-COA-MUT-MONOMER DOI 10.1016/j.micres.2008.08.006 http://dx.doi.org/10.1016/j.micres.2008.08.006 DOI 10.1021/bi015593k http://dx.doi.org/10.1021/bi015593k DOI 10.1021/bi992888d http://dx.doi.org/10.1021/bi992888d DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.4.99.2 http://www.genome.jp/dbget-bin/www_bget?EC:5.4.99.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EMBL X66836 http://www.ebi.ac.uk/ena/data/view/X66836 ENZYME 5.4.99.2 http://enzyme.expasy.org/EC/5.4.99.2 EchoBASE EB1414 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1414 EcoGene EG11444 http://www.ecogene.org/geneInfo.php?eg_id=EG11444 EnsemblBacteria AAC75954 http://www.ensemblgenomes.org/id/AAC75954 EnsemblBacteria AAC75954 http://www.ensemblgenomes.org/id/AAC75954 EnsemblBacteria BAE76981 http://www.ensemblgenomes.org/id/BAE76981 EnsemblBacteria BAE76981 http://www.ensemblgenomes.org/id/BAE76981 EnsemblBacteria BAE76981 http://www.ensemblgenomes.org/id/BAE76981 EnsemblBacteria b2917 http://www.ensemblgenomes.org/id/b2917 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004494 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004494 GO_function GO:0031419 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031419 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0008152 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008152 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.20.20.240 http://www.cathdb.info/version/latest/superfamily/3.20.20.240 Gene3D 3.40.50.280 http://www.cathdb.info/version/latest/superfamily/3.40.50.280 GeneID 945576 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945576 HOGENOM HOG000003917 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000003917&db=HOGENOM6 InParanoid P27253 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P27253 IntAct P27253 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P27253* IntEnz 5.4.99.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.4.99.2 InterPro IPR006098 http://www.ebi.ac.uk/interpro/entry/IPR006098 InterPro IPR006099 http://www.ebi.ac.uk/interpro/entry/IPR006099 InterPro IPR006158 http://www.ebi.ac.uk/interpro/entry/IPR006158 InterPro IPR006159 http://www.ebi.ac.uk/interpro/entry/IPR006159 InterPro IPR014348 http://www.ebi.ac.uk/interpro/entry/IPR014348 InterPro IPR016176 http://www.ebi.ac.uk/interpro/entry/IPR016176 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2884 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2884 KEGG_Gene eco:b2917 http://www.genome.jp/dbget-bin/www_bget?eco:b2917 KEGG_Orthology KO:K01847 http://www.genome.jp/dbget-bin/www_bget?KO:K01847 KEGG_Pathway ko00280 http://www.genome.jp/kegg-bin/show_pathway?ko00280 KEGG_Pathway ko00630 http://www.genome.jp/kegg-bin/show_pathway?ko00630 KEGG_Pathway ko00640 http://www.genome.jp/kegg-bin/show_pathway?ko00640 KEGG_Pathway ko00720 http://www.genome.jp/kegg-bin/show_pathway?ko00720 KEGG_Reaction rn:R00833 http://www.genome.jp/dbget-bin/www_bget?rn:R00833 OMA GVNKYRP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GVNKYRP PROSITE PS00544 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00544 PROSITE PS51332 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51332 PSORT swissprot:SCPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SCPA_ECOLI PSORT-B swissprot:SCPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SCPA_ECOLI PSORT2 swissprot:SCPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SCPA_ECOLI Pfam PF01642 http://pfam.xfam.org/family/PF01642 Pfam PF02310 http://pfam.xfam.org/family/PF02310 Phobius swissprot:SCPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SCPA_ECOLI PhylomeDB P27253 http://phylomedb.org/?seqid=P27253 ProteinModelPortal P27253 http://www.proteinmodelportal.org/query/uniprot/P27253 PubMed 10769117 http://www.ncbi.nlm.nih.gov/pubmed/10769117 PubMed 11955068 http://www.ncbi.nlm.nih.gov/pubmed/11955068 PubMed 1355087 http://www.ncbi.nlm.nih.gov/pubmed/1355087 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18950999 http://www.ncbi.nlm.nih.gov/pubmed/18950999 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417392 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417392 RefSeq WP_000073223 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000073223 SMR P27253 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P27253 STRING 511145.b2917 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2917&targetmode=cogs SUPFAM SSF51703 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51703 SUPFAM SSF52242 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52242 TIGRFAMs TIGR00640 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00640 TIGRFAMs TIGR00641 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00641 UniProtKB SCPA_ECOLI http://www.uniprot.org/uniprot/SCPA_ECOLI UniProtKB-AC P27253 http://www.uniprot.org/uniprot/P27253 charge swissprot:SCPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SCPA_ECOLI eggNOG COG1884 http://eggnogapi.embl.de/nog_data/html/tree/COG1884 eggNOG COG2185 http://eggnogapi.embl.de/nog_data/html/tree/COG2185 eggNOG ENOG4105D5P http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D5P epestfind swissprot:SCPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SCPA_ECOLI garnier swissprot:SCPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SCPA_ECOLI helixturnhelix swissprot:SCPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SCPA_ECOLI hmoment swissprot:SCPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SCPA_ECOLI iep swissprot:SCPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SCPA_ECOLI inforesidue swissprot:SCPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SCPA_ECOLI octanol swissprot:SCPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SCPA_ECOLI pepcoil swissprot:SCPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SCPA_ECOLI pepdigest swissprot:SCPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SCPA_ECOLI pepinfo swissprot:SCPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SCPA_ECOLI pepnet swissprot:SCPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SCPA_ECOLI pepstats swissprot:SCPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SCPA_ECOLI pepwheel swissprot:SCPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SCPA_ECOLI pepwindow swissprot:SCPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SCPA_ECOLI sigcleave swissprot:SCPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SCPA_ECOLI ## Database ID URL or Descriptions # AltName Nucleoside-transport system protein NupG {ECO 0000305} # BIOPHYSICOCHEMICAL PROPERTIES NUPG_ECOLI Kinetic parameters KM=23.6 uM for uridine {ECO 0000269|PubMed 15513740}; KM=20.6 uM for adenosine {ECO 0000269|PubMed 15513740}; Vmax=67.2 nmol/min/mg enzyme with uridine as substrate {ECO 0000269|PubMed 15513740}; Vmax=56.8 nmol/min/mg enzyme with adenosine as substrate {ECO 0000269|PubMed 15513740}; # BioGrid 4262362 111 # ENZYME REGULATION Inhibited by the protonophore uncouplers 2,4- dinitrophenol and carbonyl cyanide m-chlorophenylhydrazone (CCCP), and by valinomycin. {ECO:0000269|PubMed 15513740}. # EcoGene EG10664 nupG # FUNCTION NUPG_ECOLI Broad-specificity transporter of purine and pyrimidine nucleosides. Driven by a proton motive force. Can transport uridine, adenosine, inosine, guanosine, thymidine and cytidine. Can also transport xanthosine, but with a very low affinity. {ECO 0000269|PubMed 11466294, ECO 0000269|PubMed 15513740, ECO 0000269|PubMed 15678184, ECO 0000269|PubMed 3311747, ECO 0000269|PubMed 374403}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoliWiki. # GO_function GO:0015212 cytidine transmembrane transporter activity; IMP:EcoliWiki. # GO_function GO:0015213 uridine transmembrane transporter activity; IDA:EcoliWiki. # GO_function GO:0015214 pyrimidine nucleoside transmembrane transporter activity; IDA:EcoliWiki. # GO_function NUPG_ECOLI GO 0015506 nucleoside proton symporter activity; IEA UniProtKB-HAMAP. # GO_process GO:0015860 purine nucleoside transmembrane transport; IMP:EcoliWiki. # GO_process GO:0015862 uridine transport; IDA:EcoliWiki. # GO_process GO:0015864 pyrimidine nucleoside transport; IDA:EcoliWiki. # GO_process GO:0032238 adenosine transport; IMP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # HAMAP MF_02049 NupG # INDUCTION Transcriptionally regulated by CytR and DeoR. {ECO:0000305|PubMed 3311747}. # InterPro IPR004740 Nuc_H_symport # InterPro IPR020846 MFS_dom # InterPro IPR033667 NupG # KEGG_Brite ko02000 Transporters # MISCELLANEOUS Binding of nucleosides to NupG requires the presence of hydroxyl groups at each of the C-3' and C-5' positions of ribose. {ECO:0000269|PubMed 15678184}. # Organism NUPG_ECOLI Escherichia coli (strain K12) # PATRIC 32121344 VBIEscCol129921_3060 # PROSITE PS50850 MFS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Nucleoside permease NupG {ECO:0000255|HAMAP-Rule MF_02049, ECO:0000305} # RefSeq NP_417439 NC_000913.3 # RefSeq WP_001049791 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA69132.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY NUPG_ECOLI Belongs to the major facilitator superfamily. Nucleoside H(+) symporter (NHS) (TC 2.A.1.10) family. {ECO 0000255|HAMAP-Rule MF_02049, ECO 0000305}. # SUBCELLULAR LOCATION NUPG_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_02049, ECO 0000269|PubMed 15513740, ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 3311747}; Multi- pass membrane protein {ECO 0000255|HAMAP-Rule MF_02049}. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.10 the major facilitator superfamily (mfs) # TIGRFAMs TIGR00889 2A0110 # eggNOG ENOG4105EAA Bacteria # eggNOG ENOG410ZVFU LUCA BLAST swissprot:NUPG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NUPG_ECOLI BioCyc ECOL316407:JW2932-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2932-MONOMER BioCyc EcoCyc:NUPG-MONOMER http://biocyc.org/getid?id=EcoCyc:NUPG-MONOMER BioCyc MetaCyc:NUPG-MONOMER http://biocyc.org/getid?id=MetaCyc:NUPG-MONOMER COG COG0477 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0477 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1039/b414739a http://dx.doi.org/10.1039/b414739a DOI 10.1080/09687860400003941 http://dx.doi.org/10.1080/09687860400003941 DOI 10.1111/j.1432-1033.1987.tb13431.x http://dx.doi.org/10.1111/j.1432-1033.1987.tb13431.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.183.16.4900-4904.2001 http://dx.doi.org/10.1128/JB.183.16.4900-4904.2001 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EMBL X06174 http://www.ebi.ac.uk/ena/data/view/X06174 EchoBASE EB0658 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0658 EcoGene EG10664 http://www.ecogene.org/geneInfo.php?eg_id=EG10664 EnsemblBacteria AAC76001 http://www.ensemblgenomes.org/id/AAC76001 EnsemblBacteria AAC76001 http://www.ensemblgenomes.org/id/AAC76001 EnsemblBacteria BAE77027 http://www.ensemblgenomes.org/id/BAE77027 EnsemblBacteria BAE77027 http://www.ensemblgenomes.org/id/BAE77027 EnsemblBacteria BAE77027 http://www.ensemblgenomes.org/id/BAE77027 EnsemblBacteria b2964 http://www.ensemblgenomes.org/id/b2964 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015212 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015212 GO_function GO:0015213 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015213 GO_function GO:0015214 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015214 GO_function GO:0015506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015506 GO_process GO:0015860 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015860 GO_process GO:0015862 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015862 GO_process GO:0015864 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015864 GO_process GO:0032238 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032238 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 946282 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946282 HAMAP MF_02049 http://hamap.expasy.org/unirule/MF_02049 HOGENOM HOG000026502 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000026502&db=HOGENOM6 InParanoid P0AFF4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFF4 InterPro IPR004740 http://www.ebi.ac.uk/interpro/entry/IPR004740 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 InterPro IPR033667 http://www.ebi.ac.uk/interpro/entry/IPR033667 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2932 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2932 KEGG_Gene eco:b2964 http://www.genome.jp/dbget-bin/www_bget?eco:b2964 KEGG_Orthology KO:K03289 http://www.genome.jp/dbget-bin/www_bget?KO:K03289 OMA QGLFMMM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QGLFMMM PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:NUPG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NUPG_ECOLI PSORT-B swissprot:NUPG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NUPG_ECOLI PSORT2 swissprot:NUPG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NUPG_ECOLI Phobius swissprot:NUPG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NUPG_ECOLI PhylomeDB P0AFF4 http://phylomedb.org/?seqid=P0AFF4 ProteinModelPortal P0AFF4 http://www.proteinmodelportal.org/query/uniprot/P0AFF4 PubMed 11466294 http://www.ncbi.nlm.nih.gov/pubmed/11466294 PubMed 15513740 http://www.ncbi.nlm.nih.gov/pubmed/15513740 PubMed 15678184 http://www.ncbi.nlm.nih.gov/pubmed/15678184 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3311747 http://www.ncbi.nlm.nih.gov/pubmed/3311747 PubMed 374403 http://www.ncbi.nlm.nih.gov/pubmed/374403 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417439 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417439 RefSeq WP_001049791 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001049791 STRING 511145.b2964 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2964&targetmode=cogs STRING COG0477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0477&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.10 http://www.tcdb.org/search/result.php?tc=2.A.1.10 TIGRFAMs TIGR00889 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00889 UniProtKB NUPG_ECOLI http://www.uniprot.org/uniprot/NUPG_ECOLI UniProtKB-AC P0AFF4 http://www.uniprot.org/uniprot/P0AFF4 charge swissprot:NUPG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NUPG_ECOLI eggNOG ENOG4105EAA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EAA eggNOG ENOG410ZVFU http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZVFU epestfind swissprot:NUPG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NUPG_ECOLI garnier swissprot:NUPG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NUPG_ECOLI helixturnhelix swissprot:NUPG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NUPG_ECOLI hmoment swissprot:NUPG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NUPG_ECOLI iep swissprot:NUPG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NUPG_ECOLI inforesidue swissprot:NUPG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NUPG_ECOLI octanol swissprot:NUPG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NUPG_ECOLI pepcoil swissprot:NUPG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NUPG_ECOLI pepdigest swissprot:NUPG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NUPG_ECOLI pepinfo swissprot:NUPG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NUPG_ECOLI pepnet swissprot:NUPG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NUPG_ECOLI pepstats swissprot:NUPG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NUPG_ECOLI pepwheel swissprot:NUPG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NUPG_ECOLI pepwindow swissprot:NUPG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NUPG_ECOLI sigcleave swissprot:NUPG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NUPG_ECOLI ## Database ID URL or Descriptions # BioGrid 4259442 14 # EcoGene EG13714 ycbV # FUNCTION YCBV_ECOLI Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. {ECO 0000269|PubMed 20345943}. # GO_component GO:0009289 pilus; IEA:InterPro. # GO_process GO:0043709 cell adhesion involved in single-species biofilm formation; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0007155 cell adhesion # Gene3D 2.60.40.1090 -; 1. # INDUCTION Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression. {ECO:0000269|PubMed 20345943}. # InterPro IPR000259 Adhesion_dom_fimbrial # InterPro IPR008966 Adhesion_dom # MISCELLANEOUS The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed. {ECO:0000305|PubMed 20345943}. # Organism YCBV_ECOLI Escherichia coli (strain K12) # PATRIC 32117105 VBIEscCol129921_0977 # PIR F64834 F64834 # Pfam PF00419 Fimbrial # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCBV_ECOLI Uncharacterized fimbrial-like protein YcbV # RefSeq NP_415463 NC_000913.3 # RefSeq WP_000919497 NZ_LN832404.1 # SUPFAM SSF49401 SSF49401 # eggNOG COG3539 LUCA # eggNOG ENOG4105MX3 Bacteria BLAST swissprot:YCBV_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCBV_ECOLI BioCyc ECOL316407:JW5123-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5123-MONOMER BioCyc EcoCyc:G6485-MONOMER http://biocyc.org/getid?id=EcoCyc:G6485-MONOMER DIP DIP-48182N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48182N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1462-2920.2010.02202.x http://dx.doi.org/10.1111/j.1462-2920.2010.02202.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3478 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3478 EcoGene EG13714 http://www.ecogene.org/geneInfo.php?eg_id=EG13714 EnsemblBacteria AAC74029 http://www.ensemblgenomes.org/id/AAC74029 EnsemblBacteria AAC74029 http://www.ensemblgenomes.org/id/AAC74029 EnsemblBacteria BAA35698 http://www.ensemblgenomes.org/id/BAA35698 EnsemblBacteria BAA35698 http://www.ensemblgenomes.org/id/BAA35698 EnsemblBacteria BAA35698 http://www.ensemblgenomes.org/id/BAA35698 EnsemblBacteria b0943 http://www.ensemblgenomes.org/id/b0943 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009289 GO_process GO:0043709 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043709 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 Gene3D 2.60.40.1090 http://www.cathdb.info/version/latest/superfamily/2.60.40.1090 GeneID 945562 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945562 HOGENOM HOG000260127 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260127&db=HOGENOM6 InParanoid P75860 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75860 InterPro IPR000259 http://www.ebi.ac.uk/interpro/entry/IPR000259 InterPro IPR008966 http://www.ebi.ac.uk/interpro/entry/IPR008966 KEGG_Gene ecj:JW5123 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5123 KEGG_Gene eco:b0943 http://www.genome.jp/dbget-bin/www_bget?eco:b0943 OMA ITAKTCI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ITAKTCI PSORT swissprot:YCBV_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCBV_ECOLI PSORT-B swissprot:YCBV_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCBV_ECOLI PSORT2 swissprot:YCBV_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCBV_ECOLI Pfam PF00419 http://pfam.xfam.org/family/PF00419 Phobius swissprot:YCBV_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCBV_ECOLI PhylomeDB P75860 http://phylomedb.org/?seqid=P75860 ProteinModelPortal P75860 http://www.proteinmodelportal.org/query/uniprot/P75860 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20345943 http://www.ncbi.nlm.nih.gov/pubmed/20345943 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415463 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415463 RefSeq WP_000919497 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000919497 SMR P75860 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75860 STRING 511145.b0943 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0943&targetmode=cogs SUPFAM SSF49401 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49401 UniProtKB YCBV_ECOLI http://www.uniprot.org/uniprot/YCBV_ECOLI UniProtKB-AC P75860 http://www.uniprot.org/uniprot/P75860 charge swissprot:YCBV_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCBV_ECOLI eggNOG COG3539 http://eggnogapi.embl.de/nog_data/html/tree/COG3539 eggNOG ENOG4105MX3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105MX3 epestfind swissprot:YCBV_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCBV_ECOLI garnier swissprot:YCBV_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCBV_ECOLI helixturnhelix swissprot:YCBV_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCBV_ECOLI hmoment swissprot:YCBV_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCBV_ECOLI iep swissprot:YCBV_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCBV_ECOLI inforesidue swissprot:YCBV_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCBV_ECOLI octanol swissprot:YCBV_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCBV_ECOLI pepcoil swissprot:YCBV_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCBV_ECOLI pepdigest swissprot:YCBV_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCBV_ECOLI pepinfo swissprot:YCBV_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCBV_ECOLI pepnet swissprot:YCBV_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCBV_ECOLI pepstats swissprot:YCBV_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCBV_ECOLI pepwheel swissprot:YCBV_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCBV_ECOLI pepwindow swissprot:YCBV_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCBV_ECOLI sigcleave swissprot:YCBV_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCBV_ECOLI ## Database ID URL or Descriptions # BioGrid 4262838 8 # EcoGene EG13234 yccM # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0055114 oxidation-reduction process; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # InterPro IPR017896 4Fe4S_Fe-S-bd # InterPro IPR017900 4Fe4S_Fe_S_CS # Organism YCCM_ECOLI Escherichia coli (strain K12) # PATRIC 32117209 VBIEscCol129921_1028 # PIR F64840 F64840 # PROSITE PS00198 4FE4S_FER_1; 2 # PROSITE PS51379 4FE4S_FER_2; 2 # Pfam PF12801 Fer4_5; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCCM_ECOLI Putative electron transport protein YccM # RefSeq NP_415512 NC_000913.3 # RefSeq WP_000829662 NZ_LN832404.1 # SIMILARITY Contains 2 4Fe-4S ferredoxin-type domains. {ECO:0000255|PROSITE-ProRule PRU00711}. # SUBCELLULAR LOCATION YCCM_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG COG0348 LUCA # eggNOG ENOG4105HEE Bacteria BLAST swissprot:YCCM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCCM_ECOLI BioCyc ECOL316407:JW0977-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0977-MONOMER BioCyc EcoCyc:G6513-MONOMER http://biocyc.org/getid?id=EcoCyc:G6513-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U38541 http://www.ebi.ac.uk/ena/data/view/U38541 EchoBASE EB3023 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3023 EcoGene EG13234 http://www.ecogene.org/geneInfo.php?eg_id=EG13234 EnsemblBacteria AAC74077 http://www.ensemblgenomes.org/id/AAC74077 EnsemblBacteria AAC74077 http://www.ensemblgenomes.org/id/AAC74077 EnsemblBacteria BAA36134 http://www.ensemblgenomes.org/id/BAA36134 EnsemblBacteria BAA36134 http://www.ensemblgenomes.org/id/BAA36134 EnsemblBacteria BAA36134 http://www.ensemblgenomes.org/id/BAA36134 EnsemblBacteria b0992 http://www.ensemblgenomes.org/id/b0992 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0055114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 946295 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946295 HOGENOM HOG000269662 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000269662&db=HOGENOM6 InParanoid P52636 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P52636 InterPro IPR017896 http://www.ebi.ac.uk/interpro/entry/IPR017896 InterPro IPR017900 http://www.ebi.ac.uk/interpro/entry/IPR017900 KEGG_Gene ecj:JW0977 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0977 KEGG_Gene eco:b0992 http://www.genome.jp/dbget-bin/www_bget?eco:b0992 OMA NFWCRYL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NFWCRYL PROSITE PS00198 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00198 PROSITE PS51379 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51379 PSORT swissprot:YCCM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCCM_ECOLI PSORT-B swissprot:YCCM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCCM_ECOLI PSORT2 swissprot:YCCM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCCM_ECOLI Pfam PF12801 http://pfam.xfam.org/family/PF12801 Phobius swissprot:YCCM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCCM_ECOLI PhylomeDB P52636 http://phylomedb.org/?seqid=P52636 ProteinModelPortal P52636 http://www.proteinmodelportal.org/query/uniprot/P52636 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415512 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415512 RefSeq WP_000829662 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000829662 SMR P52636 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P52636 STRING 511145.b0992 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0992&targetmode=cogs UniProtKB YCCM_ECOLI http://www.uniprot.org/uniprot/YCCM_ECOLI UniProtKB-AC P52636 http://www.uniprot.org/uniprot/P52636 charge swissprot:YCCM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCCM_ECOLI eggNOG COG0348 http://eggnogapi.embl.de/nog_data/html/tree/COG0348 eggNOG ENOG4105HEE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105HEE epestfind swissprot:YCCM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCCM_ECOLI garnier swissprot:YCCM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCCM_ECOLI helixturnhelix swissprot:YCCM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCCM_ECOLI hmoment swissprot:YCCM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCCM_ECOLI iep swissprot:YCCM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCCM_ECOLI inforesidue swissprot:YCCM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCCM_ECOLI octanol swissprot:YCCM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCCM_ECOLI pepcoil swissprot:YCCM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCCM_ECOLI pepdigest swissprot:YCCM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCCM_ECOLI pepinfo swissprot:YCCM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCCM_ECOLI pepnet swissprot:YCCM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCCM_ECOLI pepstats swissprot:YCCM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCCM_ECOLI pepwheel swissprot:YCCM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCCM_ECOLI pepwindow swissprot:YCCM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCCM_ECOLI sigcleave swissprot:YCCM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCCM_ECOLI ## Database ID URL or Descriptions # BioGrid 4263507 3 # EcoGene EG11807 yebF # GO_component GO:0005576 extracellular region; IEA:UniProtKB-SubCell. # GOslim_component GO:0005576 extracellular region # HAMAP MF_01435 YebF # InterPro IPR020236 Uncharacterised_YebF # InterPro IPR025603 YebF/ColM_immunity # Organism YEBF_ECOLI Escherichia coli (strain K12) # PATRIC 32119015 VBIEscCol129921_1925 # PDB 2LQV NMR; -; A=22-118 # PIR G64946 G64946 # Pfam PF13995 YebF # ProDom PD077599 Vacuole-related_protein_17 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEBF_ECOLI Protein YebF # RefSeq NP_416361 NC_000913.3 # RefSeq WP_001350516 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA23859.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA15653.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the YebF family. {ECO 0000305}. # SUBCELLULAR LOCATION YEBF_ECOLI Secreted {ECO 0000269|PubMed 16369539}. # eggNOG ENOG4105RSZ Bacteria # eggNOG ENOG411244I LUCA BLAST swissprot:YEBF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEBF_ECOLI BioCyc ECOL316407:JW1836-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1836-MONOMER BioCyc EcoCyc:EG11807-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11807-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nbt1174 http://dx.doi.org/10.1038/nbt1174 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L20897 http://www.ebi.ac.uk/ena/data/view/L20897 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1755 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1755 EcoGene EG11807 http://www.ecogene.org/geneInfo.php?eg_id=EG11807 EnsemblBacteria AAC74917 http://www.ensemblgenomes.org/id/AAC74917 EnsemblBacteria AAC74917 http://www.ensemblgenomes.org/id/AAC74917 EnsemblBacteria BAA15653 http://www.ensemblgenomes.org/id/BAA15653 EnsemblBacteria BAA15653 http://www.ensemblgenomes.org/id/BAA15653 EnsemblBacteria BAA15653 http://www.ensemblgenomes.org/id/BAA15653 EnsemblBacteria b1847 http://www.ensemblgenomes.org/id/b1847 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005576 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576 GOslim_component GO:0005576 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576 GeneID 946363 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946363 HAMAP MF_01435 http://hamap.expasy.org/unirule/MF_01435 HOGENOM HOG000121241 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000121241&db=HOGENOM6 InterPro IPR020236 http://www.ebi.ac.uk/interpro/entry/IPR020236 InterPro IPR025603 http://www.ebi.ac.uk/interpro/entry/IPR025603 KEGG_Gene ecj:JW1836 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1836 KEGG_Gene eco:b1847 http://www.genome.jp/dbget-bin/www_bget?eco:b1847 OMA FPKCEGM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FPKCEGM PDB 2LQV http://www.ebi.ac.uk/pdbe-srv/view/entry/2LQV PDBsum 2LQV http://www.ebi.ac.uk/pdbsum/2LQV PSORT swissprot:YEBF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEBF_ECOLI PSORT-B swissprot:YEBF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEBF_ECOLI PSORT2 swissprot:YEBF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEBF_ECOLI Pfam PF13995 http://pfam.xfam.org/family/PF13995 Phobius swissprot:YEBF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEBF_ECOLI ProteinModelPortal P33219 http://www.proteinmodelportal.org/query/uniprot/P33219 PubMed 16369539 http://www.ncbi.nlm.nih.gov/pubmed/16369539 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416361 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416361 RefSeq WP_001350516 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001350516 SMR P33219 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33219 STRING 511145.b1847 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1847&targetmode=cogs UniProtKB YEBF_ECOLI http://www.uniprot.org/uniprot/YEBF_ECOLI UniProtKB-AC P33219 http://www.uniprot.org/uniprot/P33219 charge swissprot:YEBF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEBF_ECOLI eggNOG ENOG4105RSZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105RSZ eggNOG ENOG411244I http://eggnogapi.embl.de/nog_data/html/tree/ENOG411244I epestfind swissprot:YEBF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEBF_ECOLI garnier swissprot:YEBF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEBF_ECOLI helixturnhelix swissprot:YEBF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEBF_ECOLI hmoment swissprot:YEBF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEBF_ECOLI iep swissprot:YEBF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEBF_ECOLI inforesidue swissprot:YEBF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEBF_ECOLI octanol swissprot:YEBF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEBF_ECOLI pepcoil swissprot:YEBF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEBF_ECOLI pepdigest swissprot:YEBF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEBF_ECOLI pepinfo swissprot:YEBF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEBF_ECOLI pepnet swissprot:YEBF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEBF_ECOLI pepstats swissprot:YEBF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEBF_ECOLI pepwheel swissprot:YEBF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEBF_ECOLI pepwindow swissprot:YEBF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEBF_ECOLI sigcleave swissprot:YEBF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEBF_ECOLI ## Database ID URL or Descriptions # BRENDA 2.7.13 2026 # BioGrid 4261764 11 # CATALYTIC ACTIVITY RSTB_ECOLI ATP + protein L-histidine = ADP + protein N- phospho-L-histidine. # CDD cd06225 HAMP # EcoGene EG11233 rstB # FUNCTION RSTB_ECOLI Member of the two-component regulatory system RstB/RstA. RstB functions as a membrane-associated protein kinase that phosphorylates RstA (Probable). {ECO 0000305|PubMed 15522865}. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0000155 phosphorelay sensor kinase activity; IEA:InterPro. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0000160 phosphorelay signal transduction system; IDA:EcoCyc. # GO_process GO:0018106 peptidyl-histidine phosphorylation; IDA:EcoCyc. # GO_process GO:0046777 protein autophosphorylation; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005622 intracellular # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0007165 signal transduction # Gene3D 1.10.287.130 -; 1. # Gene3D 3.30.565.10 -; 1. # INDUCTION Induced by low extracellular levels of magnesium via the PhoQ/PhoP two-component regulatory system. {ECO:0000269|PubMed 12813061}. # IntAct P18392 3 # InterPro IPR003594 HATPase_C # InterPro IPR003660 HAMP_dom # InterPro IPR003661 HisK_dim/P # InterPro IPR004358 Sig_transdc_His_kin-like_C # InterPro IPR005467 His_kinase_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01001 Protein kinases # KEGG_Brite ko02022 M00446 RstB-RstA two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # Organism RSTB_ECOLI Escherichia coli (strain K12) # PATRIC 32118520 VBIEscCol129921_1680 # PIR C64917 C64917 # PRINTS PR00344 BCTRLSENSOR # PROSITE PS50109 HIS_KIN # PROSITE PS50885 HAMP # PTM RSTB_ECOLI Autophosphorylated. # Pfam PF00512 HisKA # Pfam PF02518 HATPase_c # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RSTB_ECOLI Sensor protein RstB # RefSeq NP_416126 NC_000913.3 # RefSeq WP_000732512 NZ_LN832404.1 # SIMILARITY Contains 1 HAMP domain. {ECO:0000255|PROSITE- ProRule PRU00102}. # SIMILARITY Contains 1 histidine kinase domain. {ECO:0000255|PROSITE-ProRule PRU00107}. # SMART SM00304 HAMP # SMART SM00387 HATPase_c # SMART SM00388 HisKA # SUBCELLULAR LOCATION RSTB_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF47384 SSF47384 # SUPFAM SSF55874 SSF55874 # eggNOG ENOG4105JJR Bacteria # eggNOG ENOG4111IA6 LUCA BLAST swissprot:RSTB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RSTB_ECOLI BioCyc ECOL316407:JW1601-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1601-MONOMER BioCyc EcoCyc:RSTB-MONOMER http://biocyc.org/getid?id=EcoCyc:RSTB-MONOMER COG COG0642 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0642 DIP DIP-10808N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10808N DOI 10.1016/0923-2508(91)90026-7 http://dx.doi.org/10.1016/0923-2508(91)90026-7 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.86.5.1593 http://dx.doi.org/10.1073/pnas.86.5.1593 DOI 10.1074/jbc.M410104200 http://dx.doi.org/10.1074/jbc.M410104200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1111/j.1365-2958.1992.tb00890.x http://dx.doi.org/10.1111/j.1365-2958.1992.tb00890.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.185.13.3696-3702.2003 http://dx.doi.org/10.1128/JB.185.13.3696-3702.2003 EC_number EC:2.7.13.3 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.13.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U41101 http://www.ebi.ac.uk/ena/data/view/U41101 EMBL X75466 http://www.ebi.ac.uk/ena/data/view/X75466 ENZYME 2.7.13.3 http://enzyme.expasy.org/EC/2.7.13.3 EchoBASE EB1215 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1215 EcoGene EG11233 http://www.ecogene.org/geneInfo.php?eg_id=EG11233 EnsemblBacteria AAC74681 http://www.ensemblgenomes.org/id/AAC74681 EnsemblBacteria AAC74681 http://www.ensemblgenomes.org/id/AAC74681 EnsemblBacteria BAA15347 http://www.ensemblgenomes.org/id/BAA15347 EnsemblBacteria BAA15347 http://www.ensemblgenomes.org/id/BAA15347 EnsemblBacteria BAA15347 http://www.ensemblgenomes.org/id/BAA15347 EnsemblBacteria b1609 http://www.ensemblgenomes.org/id/b1609 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0000155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000155 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0018106 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018106 GO_process GO:0046777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046777 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 Gene3D 1.10.287.130 http://www.cathdb.info/version/latest/superfamily/1.10.287.130 Gene3D 3.30.565.10 http://www.cathdb.info/version/latest/superfamily/3.30.565.10 GeneID 948870 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948870 HOGENOM HOG000258895 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000258895&db=HOGENOM6 InParanoid P18392 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P18392 IntAct P18392 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P18392* IntEnz 2.7.13.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.13.3 InterPro IPR003594 http://www.ebi.ac.uk/interpro/entry/IPR003594 InterPro IPR003660 http://www.ebi.ac.uk/interpro/entry/IPR003660 InterPro IPR003661 http://www.ebi.ac.uk/interpro/entry/IPR003661 InterPro IPR004358 http://www.ebi.ac.uk/interpro/entry/IPR004358 InterPro IPR005467 http://www.ebi.ac.uk/interpro/entry/IPR005467 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01001 http://www.genome.jp/dbget-bin/www_bget?ko01001 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW1601 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1601 KEGG_Gene eco:b1609 http://www.genome.jp/dbget-bin/www_bget?eco:b1609 KEGG_Orthology KO:K07639 http://www.genome.jp/dbget-bin/www_bget?KO:K07639 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA QEGSHND http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QEGSHND PRINTS PR00344 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00344 PROSITE PS50109 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50109 PROSITE PS50885 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50885 PSORT swissprot:RSTB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RSTB_ECOLI PSORT-B swissprot:RSTB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RSTB_ECOLI PSORT2 swissprot:RSTB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RSTB_ECOLI Pfam PF00512 http://pfam.xfam.org/family/PF00512 Pfam PF02518 http://pfam.xfam.org/family/PF02518 Phobius swissprot:RSTB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RSTB_ECOLI PhylomeDB P18392 http://phylomedb.org/?seqid=P18392 ProteinModelPortal P18392 http://www.proteinmodelportal.org/query/uniprot/P18392 PubMed 12813061 http://www.ncbi.nlm.nih.gov/pubmed/12813061 PubMed 1495392 http://www.ncbi.nlm.nih.gov/pubmed/1495392 PubMed 15522865 http://www.ncbi.nlm.nih.gov/pubmed/15522865 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1925016 http://www.ncbi.nlm.nih.gov/pubmed/1925016 PubMed 2646639 http://www.ncbi.nlm.nih.gov/pubmed/2646639 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416126 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416126 RefSeq WP_000732512 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000732512 SMART SM00304 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00304 SMART SM00387 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00387 SMART SM00388 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00388 SMR P18392 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P18392 STRING 511145.b1609 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1609&targetmode=cogs STRING COG0642 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0642&targetmode=cogs SUPFAM SSF47384 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47384 SUPFAM SSF55874 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55874 UniProtKB RSTB_ECOLI http://www.uniprot.org/uniprot/RSTB_ECOLI UniProtKB-AC P18392 http://www.uniprot.org/uniprot/P18392 charge swissprot:RSTB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RSTB_ECOLI eggNOG ENOG4105JJR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105JJR eggNOG ENOG4111IA6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111IA6 epestfind swissprot:RSTB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RSTB_ECOLI garnier swissprot:RSTB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RSTB_ECOLI helixturnhelix swissprot:RSTB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RSTB_ECOLI hmoment swissprot:RSTB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RSTB_ECOLI iep swissprot:RSTB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RSTB_ECOLI inforesidue swissprot:RSTB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RSTB_ECOLI octanol swissprot:RSTB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RSTB_ECOLI pepcoil swissprot:RSTB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RSTB_ECOLI pepdigest swissprot:RSTB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RSTB_ECOLI pepinfo swissprot:RSTB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RSTB_ECOLI pepnet swissprot:RSTB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RSTB_ECOLI pepstats swissprot:RSTB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RSTB_ECOLI pepwheel swissprot:RSTB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RSTB_ECOLI pepwindow swissprot:RSTB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RSTB_ECOLI sigcleave swissprot:RSTB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RSTB_ECOLI ## Database ID URL or Descriptions # BioGrid 4263346 6 # EcoGene EG13451 caiF # FUNCTION CAIF_ECOLI Potential transcriptional activator of carnitine metabolism. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0009437 carnitine metabolic process; EXP:EcoliWiki. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # IntAct P0AE58 10 # InterPro IPR020357 Tscrpt_reg_CaiF/GrlA # KEGG_Brite ko03000 Transcription factors # Organism CAIF_ECOLI Escherichia coli (strain K12) # PATRIC 32115163 VBIEscCol129921_0033 # Pfam PF07180 CaiF_GrlA # ProDom PD081346 Transcription_activatory_CaiF # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CAIF_ECOLI Transcriptional activatory protein CaiF # RefSeq NP_414576 NC_000913.3 # RefSeq WP_000333125 NZ_LN832404.1 # eggNOG ENOG4108XNW Bacteria # eggNOG ENOG4111I8M LUCA BLAST swissprot:CAIF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CAIF_ECOLI BioCyc ECOL316407:JW0033-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0033-MONOMER BioCyc EcoCyc:G6088-MONOMER http://biocyc.org/getid?id=EcoCyc:G6088-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X80644 http://www.ebi.ac.uk/ena/data/view/X80644 EchoBASE EB3224 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3224 EcoGene EG13451 http://www.ecogene.org/geneInfo.php?eg_id=EG13451 EnsemblBacteria AAC73145 http://www.ensemblgenomes.org/id/AAC73145 EnsemblBacteria AAC73145 http://www.ensemblgenomes.org/id/AAC73145 EnsemblBacteria BAE76036 http://www.ensemblgenomes.org/id/BAE76036 EnsemblBacteria BAE76036 http://www.ensemblgenomes.org/id/BAE76036 EnsemblBacteria BAE76036 http://www.ensemblgenomes.org/id/BAE76036 EnsemblBacteria b0034 http://www.ensemblgenomes.org/id/b0034 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0009437 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009437 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 944795 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944795 HOGENOM HOG000116723 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000116723&db=HOGENOM6 IntAct P0AE58 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AE58* InterPro IPR020357 http://www.ebi.ac.uk/interpro/entry/IPR020357 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW0033 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0033 KEGG_Gene eco:b0034 http://www.genome.jp/dbget-bin/www_bget?eco:b0034 KEGG_Orthology KO:K08277 http://www.genome.jp/dbget-bin/www_bget?KO:K08277 OMA TIPNQLE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TIPNQLE PSORT swissprot:CAIF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CAIF_ECOLI PSORT-B swissprot:CAIF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CAIF_ECOLI PSORT2 swissprot:CAIF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CAIF_ECOLI Pfam PF07180 http://pfam.xfam.org/family/PF07180 Phobius swissprot:CAIF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CAIF_ECOLI ProteinModelPortal P0AE58 http://www.proteinmodelportal.org/query/uniprot/P0AE58 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8631699 http://www.ncbi.nlm.nih.gov/pubmed/8631699 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414576 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414576 RefSeq WP_000333125 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000333125 STRING 511145.b0034 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0034&targetmode=cogs UniProtKB CAIF_ECOLI http://www.uniprot.org/uniprot/CAIF_ECOLI UniProtKB-AC P0AE58 http://www.uniprot.org/uniprot/P0AE58 charge swissprot:CAIF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CAIF_ECOLI eggNOG ENOG4108XNW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108XNW eggNOG ENOG4111I8M http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111I8M epestfind swissprot:CAIF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CAIF_ECOLI garnier swissprot:CAIF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CAIF_ECOLI helixturnhelix swissprot:CAIF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CAIF_ECOLI hmoment swissprot:CAIF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CAIF_ECOLI iep swissprot:CAIF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CAIF_ECOLI inforesidue swissprot:CAIF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CAIF_ECOLI octanol swissprot:CAIF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CAIF_ECOLI pepcoil swissprot:CAIF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CAIF_ECOLI pepdigest swissprot:CAIF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CAIF_ECOLI pepinfo swissprot:CAIF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CAIF_ECOLI pepnet swissprot:CAIF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CAIF_ECOLI pepstats swissprot:CAIF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CAIF_ECOLI pepwheel swissprot:CAIF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CAIF_ECOLI pepwindow swissprot:CAIF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CAIF_ECOLI sigcleave swissprot:CAIF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CAIF_ECOLI ## Database ID URL or Descriptions # BioGrid 4259711 165 # EcoGene EG14008 ynjF # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0016780 phosphotransferase activity, for other substituted phosphate groups; IEA:InterPro. # GO_process GO:0008654 phospholipid biosynthetic process; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # InterPro IPR000462 CDP-OH_P_trans # Organism YNJF_ECOLI Escherichia coli (strain K12) # PATRIC 32118827 VBIEscCol129921_1831 # PIR F64935 F64935 # PROSITE PS00379 CDP_ALCOHOL_P_TRANSF # Pfam PF01066 CDP-OH_P_transf # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNJF_ECOLI Inner membrane protein YnjF # RefSeq NP_416272 NC_000913.3 # RefSeq WP_001295484 NZ_LN832404.1 # SIMILARITY Belongs to the CDP-alcohol phosphatidyltransferase class-I family. {ECO 0000305}. # SUBCELLULAR LOCATION YNJF_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG COG0558 LUCA # eggNOG ENOG4108T9J Bacteria BLAST swissprot:YNJF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNJF_ECOLI BioCyc ECOL316407:JW1747-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1747-MONOMER BioCyc EcoCyc:G6953-MONOMER http://biocyc.org/getid?id=EcoCyc:G6953-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3764 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3764 EcoGene EG14008 http://www.ecogene.org/geneInfo.php?eg_id=EG14008 EnsemblBacteria AAC74828 http://www.ensemblgenomes.org/id/AAC74828 EnsemblBacteria AAC74828 http://www.ensemblgenomes.org/id/AAC74828 EnsemblBacteria BAE76522 http://www.ensemblgenomes.org/id/BAE76522 EnsemblBacteria BAE76522 http://www.ensemblgenomes.org/id/BAE76522 EnsemblBacteria BAE76522 http://www.ensemblgenomes.org/id/BAE76522 EnsemblBacteria b1758 http://www.ensemblgenomes.org/id/b1758 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0016780 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016780 GO_process GO:0008654 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008654 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 946221 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946221 HOGENOM HOG000275263 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275263&db=HOGENOM6 InParanoid P76226 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76226 InterPro IPR000462 http://www.ebi.ac.uk/interpro/entry/IPR000462 KEGG_Gene ecj:JW1747 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1747 KEGG_Gene eco:b1758 http://www.genome.jp/dbget-bin/www_bget?eco:b1758 OMA FLAFAIM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FLAFAIM PROSITE PS00379 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00379 PSORT swissprot:YNJF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNJF_ECOLI PSORT-B swissprot:YNJF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNJF_ECOLI PSORT2 swissprot:YNJF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNJF_ECOLI Pfam PF01066 http://pfam.xfam.org/family/PF01066 Phobius swissprot:YNJF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNJF_ECOLI PhylomeDB P76226 http://phylomedb.org/?seqid=P76226 ProteinModelPortal P76226 http://www.proteinmodelportal.org/query/uniprot/P76226 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416272 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416272 RefSeq WP_001295484 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295484 STRING 511145.b1758 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1758&targetmode=cogs UniProtKB YNJF_ECOLI http://www.uniprot.org/uniprot/YNJF_ECOLI UniProtKB-AC P76226 http://www.uniprot.org/uniprot/P76226 charge swissprot:YNJF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNJF_ECOLI eggNOG COG0558 http://eggnogapi.embl.de/nog_data/html/tree/COG0558 eggNOG ENOG4108T9J http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108T9J epestfind swissprot:YNJF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNJF_ECOLI garnier swissprot:YNJF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNJF_ECOLI helixturnhelix swissprot:YNJF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNJF_ECOLI hmoment swissprot:YNJF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNJF_ECOLI iep swissprot:YNJF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNJF_ECOLI inforesidue swissprot:YNJF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNJF_ECOLI octanol swissprot:YNJF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNJF_ECOLI pepcoil swissprot:YNJF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNJF_ECOLI pepdigest swissprot:YNJF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNJF_ECOLI pepinfo swissprot:YNJF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNJF_ECOLI pepnet swissprot:YNJF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNJF_ECOLI pepstats swissprot:YNJF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNJF_ECOLI pepwheel swissprot:YNJF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNJF_ECOLI pepwindow swissprot:YNJF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNJF_ECOLI sigcleave swissprot:YNJF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNJF_ECOLI ## Database ID URL or Descriptions # BioGrid 4262768 97 # CATALYTIC ACTIVITY T1MK_ECOLI S-adenosyl-L-methionine + adenine in DNA = S- adenosyl-L-homocysteine + N-6-methyladenine in DNA. # EcoGene EG10458 hsdM # FUNCTION T1MK_ECOLI The M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of a bipartite DNA recognition sequence. In the presence of the R subunit the complex can also act as an endonuclease, binding to the same target sequence but cutting the DNA some distance from this site. Whether the DNA is cut or modified depends on the methylation state of the target sequence. When the target site is unmodified, the DNA is cut. When the target site is hemimethylated, the complex acts as a maintenance MTase modifying the DNA so that both strands become methylated. The EcoKI enzyme recognizes 5'-AACN(6)GTGC-3'. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_function GO:0008170 N-methyltransferase activity; IMP:EcoliWiki. # GO_function GO:0009007 site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC. # GO_process GO:0009307 DNA restriction-modification system; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # Gene3D 3.40.50.150 -; 1. # IntAct P08957 14 # InterPro IPR002052 DNA_methylase_N6_adenine_CS # InterPro IPR003356 DNA_methylase_A-5 # InterPro IPR022749 D12N6_MeTrfase_N # InterPro IPR029063 SAM-dependent_MTases # KEGG_Brite ko01000 Enzymes # MISCELLANEOUS T1MK_ECOLI Type I restriction and modification enzymes are complex, multifunctional systems which require ATP, S-adenosyl methionine and Mg(2+) as cofactors and, in addition to their endonucleolytic and methylase activities, are potent DNA-dependent ATPases. # Organism T1MK_ECOLI Escherichia coli (strain K12) # PATRIC 32124304 VBIEscCol129921_4495 # PDB 2AR0 X-ray; 2.80 A; A/B=2-527 # PDB 2Y7C EM; 18.00 A; B/C=1-529 # PDB 2Y7H EM; 18.00 A; B/C=1-529 # PIR B30375 XYECHM # PROSITE PS00092 N6_MTASE # Pfam PF02384 N6_Mtase # Pfam PF12161 HsdM_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # REBASE 3387 M.EcoKI # RecName T1MK_ECOLI Type I restriction enzyme EcoKI M protein # RefSeq NP_418769 NC_000913.3 # RefSeq WP_001063204 NZ_LN832404.1 # SIMILARITY Belongs to the N(4)/N(6)-methyltransferase family. {ECO 0000305}. # SUBUNIT T1MK_ECOLI The type I restriction/modification system is composed of three polypeptides R, M and S. # SUPFAM SSF53335 SSF53335 # eggNOG COG0286 LUCA # eggNOG ENOG4105CVR Bacteria BLAST swissprot:T1MK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:T1MK_ECOLI BioCyc ECOL316407:JW4312-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4312-MONOMER BioCyc EcoCyc:EG10458-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10458-MONOMER BioCyc MetaCyc:EG10458-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10458-MONOMER COG COG0286 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0286 DIP DIP-9943N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9943N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0022-2836(87)90303-2 http://dx.doi.org/10.1016/0022-2836(87)90303-2 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.1.72 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.72 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X06545 http://www.ebi.ac.uk/ena/data/view/X06545 ENZYME 2.1.1.72 http://enzyme.expasy.org/EC/2.1.1.72 EchoBASE EB0453 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0453 EcoGene EG10458 http://www.ecogene.org/geneInfo.php?eg_id=EG10458 EnsemblBacteria AAC77305 http://www.ensemblgenomes.org/id/AAC77305 EnsemblBacteria AAC77305 http://www.ensemblgenomes.org/id/AAC77305 EnsemblBacteria BAE78339 http://www.ensemblgenomes.org/id/BAE78339 EnsemblBacteria BAE78339 http://www.ensemblgenomes.org/id/BAE78339 EnsemblBacteria BAE78339 http://www.ensemblgenomes.org/id/BAE78339 EnsemblBacteria b4349 http://www.ensemblgenomes.org/id/b4349 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0008170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008170 GO_function GO:0009007 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009007 GO_process GO:0009307 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009307 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 GeneID 948872 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948872 HOGENOM HOG000295041 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000295041&db=HOGENOM6 InParanoid P08957 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P08957 IntAct P08957 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P08957* IntEnz 2.1.1.72 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.72 InterPro IPR002052 http://www.ebi.ac.uk/interpro/entry/IPR002052 InterPro IPR003356 http://www.ebi.ac.uk/interpro/entry/IPR003356 InterPro IPR022749 http://www.ebi.ac.uk/interpro/entry/IPR022749 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4312 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4312 KEGG_Gene eco:b4349 http://www.genome.jp/dbget-bin/www_bget?eco:b4349 KEGG_Orthology KO:K03427 http://www.genome.jp/dbget-bin/www_bget?KO:K03427 MINT MINT-1252160 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1252160 OMA INYSDYV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=INYSDYV PDB 2AR0 http://www.ebi.ac.uk/pdbe-srv/view/entry/2AR0 PDB 2Y7C http://www.ebi.ac.uk/pdbe-srv/view/entry/2Y7C PDB 2Y7H http://www.ebi.ac.uk/pdbe-srv/view/entry/2Y7H PDBsum 2AR0 http://www.ebi.ac.uk/pdbsum/2AR0 PDBsum 2Y7C http://www.ebi.ac.uk/pdbsum/2Y7C PDBsum 2Y7H http://www.ebi.ac.uk/pdbsum/2Y7H PROSITE PS00092 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00092 PSORT swissprot:T1MK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:T1MK_ECOLI PSORT-B swissprot:T1MK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:T1MK_ECOLI PSORT2 swissprot:T1MK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:T1MK_ECOLI Pfam PF02384 http://pfam.xfam.org/family/PF02384 Pfam PF12161 http://pfam.xfam.org/family/PF12161 Phobius swissprot:T1MK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:T1MK_ECOLI PhylomeDB P08957 http://phylomedb.org/?seqid=P08957 ProteinModelPortal P08957 http://www.proteinmodelportal.org/query/uniprot/P08957 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3323532 http://www.ncbi.nlm.nih.gov/pubmed/3323532 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 REBASE 3387 http://rebase.neb.com/rebase/enz/3387.html RefSeq NP_418769 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418769 RefSeq WP_001063204 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001063204 SMR P08957 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P08957 STRING 511145.b4349 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4349&targetmode=cogs STRING COG0286 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0286&targetmode=cogs SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 UniProtKB T1MK_ECOLI http://www.uniprot.org/uniprot/T1MK_ECOLI UniProtKB-AC P08957 http://www.uniprot.org/uniprot/P08957 charge swissprot:T1MK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:T1MK_ECOLI eggNOG COG0286 http://eggnogapi.embl.de/nog_data/html/tree/COG0286 eggNOG ENOG4105CVR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CVR epestfind swissprot:T1MK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:T1MK_ECOLI garnier swissprot:T1MK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:T1MK_ECOLI helixturnhelix swissprot:T1MK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:T1MK_ECOLI hmoment swissprot:T1MK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:T1MK_ECOLI iep swissprot:T1MK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:T1MK_ECOLI inforesidue swissprot:T1MK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:T1MK_ECOLI octanol swissprot:T1MK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:T1MK_ECOLI pepcoil swissprot:T1MK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:T1MK_ECOLI pepdigest swissprot:T1MK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:T1MK_ECOLI pepinfo swissprot:T1MK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:T1MK_ECOLI pepnet swissprot:T1MK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:T1MK_ECOLI pepstats swissprot:T1MK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:T1MK_ECOLI pepwheel swissprot:T1MK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:T1MK_ECOLI pepwindow swissprot:T1MK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:T1MK_ECOLI sigcleave swissprot:T1MK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:T1MK_ECOLI ## Database ID URL or Descriptions # BioGrid 4263310 342 # CAZy GT4 Glycosyltransferase Family 4 # EcoGene EG11790 wcaI # GO_function GO:0016740 transferase activity; IEA:UniProtKB-KW. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0045228 slime layer polysaccharide biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # InterPro IPR001296 Glyco_trans_1 # InterPro IPR023910 Colanic_acid_synth_WcaI # InterPro IPR028098 Glyco_trans_4-like_N # Organism WCAI_ECOLI Escherichia coli (strain K12) # PATHWAY WCAI_ECOLI Slime biogenesis; slime polysaccharide biosynthesis. # PATRIC 32119433 VBIEscCol129921_2127 # PIR F55239 F55239 # Pfam PF00534 Glycos_transf_1 # Pfam PF13579 Glyco_trans_4_4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName WCAI_ECOLI Putative colanic acid biosynthesis glycosyl transferase WcaI # RefSeq NP_416554 NC_000913.3 # RefSeq WP_000699693 NZ_LN832404.1 # TIGRFAMs TIGR04007 wcaI # eggNOG COG0438 LUCA # eggNOG ENOG4106CD9 Bacteria BLAST swissprot:WCAI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:WCAI_ECOLI BioCyc ECOL316407:JW2035-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2035-MONOMER BioCyc EcoCyc:EG11790-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11790-MONOMER COG CAZy: http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=CAZy: COG COG0438 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0438 COG GT4 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=GT4 DIP DIP-11124N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11124N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U38473 http://www.ebi.ac.uk/ena/data/view/U38473 EchoBASE EB1738 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1738 EcoGene EG11790 http://www.ecogene.org/geneInfo.php?eg_id=EG11790 EnsemblBacteria AAC75111 http://www.ensemblgenomes.org/id/AAC75111 EnsemblBacteria AAC75111 http://www.ensemblgenomes.org/id/AAC75111 EnsemblBacteria BAA15906 http://www.ensemblgenomes.org/id/BAA15906 EnsemblBacteria BAA15906 http://www.ensemblgenomes.org/id/BAA15906 EnsemblBacteria BAA15906 http://www.ensemblgenomes.org/id/BAA15906 EnsemblBacteria b2050 http://www.ensemblgenomes.org/id/b2050 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016740 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016740 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GO_process GO:0045228 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045228 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 946588 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946588 HOGENOM HOG000079950 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000079950&db=HOGENOM6 InParanoid P32057 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32057 IntAct P32057 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32057* InterPro IPR001296 http://www.ebi.ac.uk/interpro/entry/IPR001296 InterPro IPR023910 http://www.ebi.ac.uk/interpro/entry/IPR023910 InterPro IPR028098 http://www.ebi.ac.uk/interpro/entry/IPR028098 KEGG_Gene ecj:JW2035 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2035 KEGG_Gene eco:b2050 http://www.genome.jp/dbget-bin/www_bget?eco:b2050 KEGG_Orthology KO:K03208 http://www.genome.jp/dbget-bin/www_bget?KO:K03208 MINT MINT-1309672 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1309672 OMA WMAREGH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WMAREGH PSORT swissprot:WCAI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:WCAI_ECOLI PSORT-B swissprot:WCAI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:WCAI_ECOLI PSORT2 swissprot:WCAI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:WCAI_ECOLI Pfam PF00534 http://pfam.xfam.org/family/PF00534 Pfam PF13579 http://pfam.xfam.org/family/PF13579 Phobius swissprot:WCAI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:WCAI_ECOLI PhylomeDB P32057 http://phylomedb.org/?seqid=P32057 ProteinModelPortal P32057 http://www.proteinmodelportal.org/query/uniprot/P32057 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7815923 http://www.ncbi.nlm.nih.gov/pubmed/7815923 PubMed 8759852 http://www.ncbi.nlm.nih.gov/pubmed/8759852 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416554 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416554 RefSeq WP_000699693 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000699693 STRING 511145.b2050 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2050&targetmode=cogs STRING CAZy: http://string-db.org/newstring_cgi/show_network_section.pl?identifier=CAZy:&targetmode=cogs STRING COG0438 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0438&targetmode=cogs STRING GT4 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=GT4&targetmode=cogs TIGRFAMs TIGR04007 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR04007 UniProtKB WCAI_ECOLI http://www.uniprot.org/uniprot/WCAI_ECOLI UniProtKB-AC P32057 http://www.uniprot.org/uniprot/P32057 charge swissprot:WCAI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:WCAI_ECOLI eggNOG COG0438 http://eggnogapi.embl.de/nog_data/html/tree/COG0438 eggNOG ENOG4106CD9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106CD9 epestfind swissprot:WCAI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:WCAI_ECOLI garnier swissprot:WCAI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:WCAI_ECOLI helixturnhelix swissprot:WCAI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:WCAI_ECOLI hmoment swissprot:WCAI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:WCAI_ECOLI iep swissprot:WCAI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:WCAI_ECOLI inforesidue swissprot:WCAI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:WCAI_ECOLI octanol swissprot:WCAI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:WCAI_ECOLI pepcoil swissprot:WCAI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:WCAI_ECOLI pepdigest swissprot:WCAI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:WCAI_ECOLI pepinfo swissprot:WCAI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:WCAI_ECOLI pepnet swissprot:WCAI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:WCAI_ECOLI pepstats swissprot:WCAI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:WCAI_ECOLI pepwheel swissprot:WCAI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:WCAI_ECOLI pepwindow swissprot:WCAI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:WCAI_ECOLI sigcleave swissprot:WCAI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:WCAI_ECOLI ## Database ID URL or Descriptions # BRENDA 5.4.99.62 2026 # BioGrid 4261236 7 # CATALYTIC ACTIVITY Beta-D-allopyranose = beta-D-allofuranose. {ECO:0000269|PubMed 15060078}. # CATALYTIC ACTIVITY Beta-D-ribopyranose = beta-D-ribofuranose. {ECO:0000269|PubMed 15060078}. # CAUTION RBSD_ECOLI Was originally thought (PubMed 3011793) to be a high affinity ribose transport protein, but further analysis (PubMed 15060078) shows that it is a D-ribose pyranase. {ECO 0000305|PubMed 15060078, ECO 0000305|PubMed 3011793}. # EcoGene EG10817 rbsD # FUNCTION RBSD_ECOLI Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose. It also catalyzes the conversion between beta-allofuranose and beta-allopyranose. {ECO 0000269|PubMed 15060078}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0016866 intramolecular transferase activity; IDA:EcoCyc. # GO_function GO:0016872 intramolecular lyase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0048029 monosaccharide binding; IEA:InterPro. # GO_process GO:0019303 D-ribose catabolic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.1650.10 -; 1. # HAMAP MF_01661 D_rib_pyranase # InterPro IPR007721 RbsD_FucU # InterPro IPR023064 D-ribose_pyranase # InterPro IPR023750 RbsD-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko02010 ABC transporters # Organism RBSD_ECOLI Escherichia coli (strain K12) # PATHWAY Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose step 1/2. # PATRIC 32122995 VBIEscCol129921_3873 # PIR E65178 E65178 # Pfam PF05025 RbsD_FucU # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RBSD_ECOLI D-ribose pyranase # RefSeq NP_418204 NC_000913.3 # RefSeq WP_001301979 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA62101.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the RbsD / FucU family. RbsD subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION RBSD_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT RBSD_ECOLI Homodecamer. {ECO 0000269|PubMed 12738765, ECO 0000269|PubMed 16731978}. # SUPFAM SSF102546 SSF102546 # UniPathway UPA00916 UER00888 # eggNOG COG1869 LUCA # eggNOG ENOG4105MRB Bacteria BLAST swissprot:RBSD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RBSD_ECOLI BioCyc ECOL316407:JW5857-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5857-MONOMER BioCyc EcoCyc:EG10817-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10817-MONOMER BioCyc MetaCyc:EG10817-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10817-MONOMER COG COG1869 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1869 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M304523200 http://dx.doi.org/10.1074/jbc.M304523200 DOI 10.1074/jbc.M402016200 http://dx.doi.org/10.1074/jbc.M402016200 DOI 10.1107/S0907444901003109 http://dx.doi.org/10.1107/S0907444901003109 DOI 10.1110/ps.062175806 http://dx.doi.org/10.1110/ps.062175806 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1266/ggs.82.291 http://dx.doi.org/10.1266/ggs.82.291 EC_number EC:5.4.99.62 {ECO:0000269|PubMed:15060078} http://www.genome.jp/dbget-bin/www_bget?EC:5.4.99.62 {ECO:0000269|PubMed:15060078} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M13169 http://www.ebi.ac.uk/ena/data/view/M13169 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X68551 http://www.ebi.ac.uk/ena/data/view/X68551 ENZYME 5.4.99.62 {ECO:0000269|PubMed:15060078} http://enzyme.expasy.org/EC/5.4.99.62 {ECO:0000269|PubMed:15060078} EchoBASE EB0810 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0810 EcoGene EG10817 http://www.ecogene.org/geneInfo.php?eg_id=EG10817 EnsemblBacteria AAC76771 http://www.ensemblgenomes.org/id/AAC76771 EnsemblBacteria AAC76771 http://www.ensemblgenomes.org/id/AAC76771 EnsemblBacteria BAE77540 http://www.ensemblgenomes.org/id/BAE77540 EnsemblBacteria BAE77540 http://www.ensemblgenomes.org/id/BAE77540 EnsemblBacteria BAE77540 http://www.ensemblgenomes.org/id/BAE77540 EnsemblBacteria b3748 http://www.ensemblgenomes.org/id/b3748 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0016866 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016866 GO_function GO:0016872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016872 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0048029 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048029 GO_process GO:0019303 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019303 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.1650.10 http://www.cathdb.info/version/latest/superfamily/3.40.1650.10 GeneID 948267 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948267 HAMAP MF_01661 http://hamap.expasy.org/unirule/MF_01661 HOGENOM HOG000219040 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219040&db=HOGENOM6 InParanoid P04982 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P04982 IntEnz 5.4.99.62 {ECO:0000269|PubMed:15060078} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.4.99.62 {ECO:0000269|PubMed:15060078} InterPro IPR007721 http://www.ebi.ac.uk/interpro/entry/IPR007721 InterPro IPR023064 http://www.ebi.ac.uk/interpro/entry/IPR023064 InterPro IPR023750 http://www.ebi.ac.uk/interpro/entry/IPR023750 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5857 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5857 KEGG_Gene eco:b3748 http://www.genome.jp/dbget-bin/www_bget?eco:b3748 KEGG_Orthology KO:K06726 http://www.genome.jp/dbget-bin/www_bget?KO:K06726 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 KEGG_Reaction rn:R08247 http://www.genome.jp/dbget-bin/www_bget?rn:R08247 OMA IIRTGEC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IIRTGEC PSORT swissprot:RBSD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RBSD_ECOLI PSORT-B swissprot:RBSD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RBSD_ECOLI PSORT2 swissprot:RBSD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RBSD_ECOLI Pfam PF05025 http://pfam.xfam.org/family/PF05025 Phobius swissprot:RBSD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RBSD_ECOLI PhylomeDB P04982 http://phylomedb.org/?seqid=P04982 ProteinModelPortal P04982 http://www.proteinmodelportal.org/query/uniprot/P04982 PubMed 11320319 http://www.ncbi.nlm.nih.gov/pubmed/11320319 PubMed 12738765 http://www.ncbi.nlm.nih.gov/pubmed/12738765 PubMed 15060078 http://www.ncbi.nlm.nih.gov/pubmed/15060078 PubMed 16731978 http://www.ncbi.nlm.nih.gov/pubmed/16731978 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17895580 http://www.ncbi.nlm.nih.gov/pubmed/17895580 PubMed 3011793 http://www.ncbi.nlm.nih.gov/pubmed/3011793 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 8226635 http://www.ncbi.nlm.nih.gov/pubmed/8226635 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418204 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418204 RefSeq WP_001301979 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001301979 SMR P04982 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P04982 STRING 511145.b3748 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3748&targetmode=cogs STRING COG1869 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1869&targetmode=cogs SUPFAM SSF102546 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF102546 UniProtKB RBSD_ECOLI http://www.uniprot.org/uniprot/RBSD_ECOLI UniProtKB-AC P04982 http://www.uniprot.org/uniprot/P04982 charge swissprot:RBSD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RBSD_ECOLI eggNOG COG1869 http://eggnogapi.embl.de/nog_data/html/tree/COG1869 eggNOG ENOG4105MRB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105MRB epestfind swissprot:RBSD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RBSD_ECOLI garnier swissprot:RBSD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RBSD_ECOLI helixturnhelix swissprot:RBSD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RBSD_ECOLI hmoment swissprot:RBSD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RBSD_ECOLI iep swissprot:RBSD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RBSD_ECOLI inforesidue swissprot:RBSD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RBSD_ECOLI octanol swissprot:RBSD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RBSD_ECOLI pepcoil swissprot:RBSD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RBSD_ECOLI pepdigest swissprot:RBSD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RBSD_ECOLI pepinfo swissprot:RBSD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RBSD_ECOLI pepnet swissprot:RBSD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RBSD_ECOLI pepstats swissprot:RBSD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RBSD_ECOLI pepwheel swissprot:RBSD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RBSD_ECOLI pepwindow swissprot:RBSD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RBSD_ECOLI sigcleave swissprot:RBSD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RBSD_ECOLI ## Database ID URL or Descriptions # EcoGene EG10880 rplS # FUNCTION RL19_ECOLI This protein is located at the 30S-50S ribosomal subunit interface. In the 70S ribosome it has been modeled to make two contacts with the 16S rRNA of the 30S subunit forming part of bridges B6 and B8 (PubMed 12809609). In the 3.5 A resolved structures L14 and L19 interact and together make contact with the 16S rRNA (PubMed 16272117). The protein conformation is quite different between the 50S and 70S structures, which may be necessary for translocation. {ECO 0000269|PubMed 12809609, ECO 0000269|PubMed 16272117}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0022625 cytosolic large ribosomal subunit; IDA:EcoCyc. # GO_function GO:0003735 structural constituent of ribosome; IBA:GO_Central. # GO_function GO:0019843 rRNA binding; IEA:UniProtKB-KW. # GO_process GO:0006412 translation; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_function GO:0019843 rRNA binding # GOslim_process GO:0006412 translation # HAMAP MF_00402 Ribosomal_L19 # INDUCTION Part of the rpsP-rimM-trmD-rplS operon. {ECO:0000269|PubMed 6357787}. # IntAct P0A7K6 101 # InterPro IPR001857 Ribosomal_L19 # InterPro IPR008991 Translation_prot_SH3-like # InterPro IPR018257 Ribosomal_L19_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=13001.7; Method=MALDI; Range=2-115; Evidence={ECO:0000269|PubMed 10094780}; # Organism RL19_ECOLI Escherichia coli (strain K12) # PANTHER PTHR15680 PTHR15680 # PATRIC 32120611 VBIEscCol129921_2704 # PDB 2J28 EM; 8.00 A; P=2-115 # PDB 2RDO EM; 9.10 A; P=2-115 # PDB 3BBX EM; 10.00 A; P=2-115 # PDB 3J5L EM; 6.60 A; P=2-115 # PDB 3J7Z EM; 3.90 A; P=1-115 # PDB 3J8G EM; 5.00 A; P=1-115 # PDB 3J9Y EM; 3.90 A; P=1-115 # PDB 3J9Z EM; 3.60 A; LM=2-115 # PDB 3JA1 EM; 3.60 A; LR=2-115 # PDB 3JBU EM; 3.64 A; p=1-115 # PDB 3JBV EM; 3.32 A; p=1-115 # PDB 3JCD EM; 3.70 A; P=1-115 # PDB 3JCE EM; 3.20 A; P=1-115 # PDB 3JCJ EM; 3.70 A; O=1-115 # PDB 3JCN EM; 4.60 A; P=1-115 # PDB 4CSU EM; 5.50 A; P=2-115 # PDB 4U1U X-ray; 2.95 A; BP/DP=2-115 # PDB 4U1V X-ray; 3.00 A; BP/DP=2-115 # PDB 4U20 X-ray; 2.90 A; BP/DP=2-115 # PDB 4U24 X-ray; 2.90 A; BP/DP=2-115 # PDB 4U25 X-ray; 2.90 A; BP/DP=2-115 # PDB 4U26 X-ray; 2.80 A; BP/DP=2-115 # PDB 4U27 X-ray; 2.80 A; BP/DP=2-115 # PDB 4UY8 EM; 3.80 A; P=2-115 # PDB 4V47 EM; 12.30 A; AN=2-115 # PDB 4V48 EM; 11.50 A; AN=2-115 # PDB 4V4H X-ray; 3.46 A; BP/DP=1-115 # PDB 4V4Q X-ray; 3.46 A; BP/DP=2-115 # PDB 4V4V EM; 15.00 A; BN=2-115 # PDB 4V4W EM; 15.00 A; BN=2-115 # PDB 4V50 X-ray; 3.22 A; BP/DP=2-115 # PDB 4V52 X-ray; 3.21 A; BP/DP=2-115 # PDB 4V53 X-ray; 3.54 A; BP/DP=2-115 # PDB 4V54 X-ray; 3.30 A; BP/DP=2-115 # PDB 4V55 X-ray; 4.00 A; BP/DP=2-115 # PDB 4V56 X-ray; 3.93 A; BP/DP=2-115 # PDB 4V57 X-ray; 3.50 A; BP/DP=2-115 # PDB 4V5B X-ray; 3.74 A; AP/CP=2-115 # PDB 4V5H EM; 5.80 A; BP=2-115 # PDB 4V5Y X-ray; 4.45 A; BP/DP=2-115 # PDB 4V64 X-ray; 3.50 A; BP/DP=2-115 # PDB 4V65 EM; 9.00 A; BI=1-115 # PDB 4V66 EM; 9.00 A; BI=1-115 # PDB 4V69 EM; 6.70 A; BP=2-115 # PDB 4V6C X-ray; 3.19 A; BP/DP=1-115 # PDB 4V6D X-ray; 3.81 A; BP/DP=1-115 # PDB 4V6E X-ray; 3.71 A; BP/DP=1-115 # PDB 4V6K EM; 8.25 A; AQ=1-115 # PDB 4V6L EM; 13.20 A; BQ=1-115 # PDB 4V6M EM; 7.10 A; BP=2-115 # PDB 4V6N EM; 12.10 A; AR=2-115 # PDB 4V6O EM; 14.70 A; BR=2-115 # PDB 4V6P EM; 13.50 A; BR=2-115 # PDB 4V6Q EM; 11.50 A; BR=2-115 # PDB 4V6R EM; 11.50 A; BR=2-115 # PDB 4V6S EM; 13.10 A; AR=2-115 # PDB 4V6T EM; 8.30 A; BP=2-115 # PDB 4V6V EM; 9.80 A; BT=2-115 # PDB 4V6Y EM; 12.00 A; BP=1-115 # PDB 4V6Z EM; 12.00 A; BP=1-115 # PDB 4V70 EM; 17.00 A; BP=1-115 # PDB 4V71 EM; 20.00 A; BP=1-115 # PDB 4V72 EM; 13.00 A; BP=1-115 # PDB 4V73 EM; 15.00 A; BP=1-115 # PDB 4V74 EM; 17.00 A; BP=1-115 # PDB 4V75 EM; 12.00 A; BP=1-115 # PDB 4V76 EM; 17.00 A; BP=1-115 # PDB 4V77 EM; 17.00 A; BP=1-115 # PDB 4V78 EM; 20.00 A; BP=1-115 # PDB 4V79 EM; 15.00 A; BP=1-115 # PDB 4V7A EM; 9.00 A; BP=1-115 # PDB 4V7B EM; 6.80 A; BP=1-115 # PDB 4V7C EM; 7.60 A; BR=2-115 # PDB 4V7D EM; 7.60 A; AS=2-115 # PDB 4V7I EM; 9.60 A; AP=1-115 # PDB 4V7S X-ray; 3.25 A; BP/DP=2-115 # PDB 4V7T X-ray; 3.19 A; BP/DP=2-115 # PDB 4V7U X-ray; 3.10 A; BP/DP=2-115 # PDB 4V7V X-ray; 3.29 A; BP/DP=2-115 # PDB 4V85 X-ray; 3.20 A; T=1-115 # PDB 4V89 X-ray; 3.70 A; BT=1-115 # PDB 4V9C X-ray; 3.30 A; BP/DP=1-115 # PDB 4V9D X-ray; 3.00 A; CP/DP=2-115 # PDB 4V9O X-ray; 2.90 A; AP/CP/EP/GP=1-115 # PDB 4V9P X-ray; 2.90 A; AP/CP/EP/GP=1-115 # PDB 4WF1 X-ray; 3.09 A; BP/DP=2-115 # PDB 4WOI X-ray; 3.00 A; BP/CP=1-115 # PDB 4WWW X-ray; 3.10 A; RP/YP=2-115 # PDB 4YBB X-ray; 2.10 A; CQ/DQ=2-115 # PDB 5ADY EM; 4.50 A; P=1-115 # PDB 5AFI EM; 2.90 A; P=1-115 # PDB 5AKA EM; 5.70 A; P=2-115 # PDB 5GAD EM; 3.70 A; Q=1-115 # PDB 5GAE EM; 3.33 A; Q=1-115 # PDB 5GAF EM; 4.30 A; Q=2-115 # PDB 5GAG EM; 3.80 A; Q=1-115 # PDB 5GAH EM; 3.80 A; Q=1-115 # PDB 5IQR EM; 3.00 A; P=1-115 # PDB 5IT8 X-ray; 3.12 A; CQ/DQ=2-115 # PDB 5J5B X-ray; 2.80 A; CQ/DQ=2-115 # PDB 5J7L X-ray; 3.00 A; CQ/DQ=2-115 # PDB 5J88 X-ray; 3.32 A; CQ/DQ=2-115 # PDB 5J8A X-ray; 3.10 A; CQ/DQ=2-115 # PDB 5J91 X-ray; 2.96 A; CQ/DQ=2-115 # PDB 5JC9 X-ray; 3.03 A; CQ/DQ=2-115 # PDB 5JTE EM; 3.60 A; BP=1-115 # PDB 5JU8 EM; 3.60 A; BP=1-115 # PDB 5KCR EM; 3.60 A; 1T=1-115 # PDB 5KCS EM; 3.90 A; 1T=1-115 # PDB 5KPS EM; 3.90 A; P=1-115 # PDB 5KPV EM; 4.10 A; O=1-115 # PDB 5KPW EM; 3.90 A; O=1-115 # PDB 5KPX EM; 3.90 A; O=1-115 # PDB 5L3P EM; 3.70 A; T=1-115 # PIR S07951 R5EC19 # PIRSF PIRSF002191 Ribosomal_L19 # PRINTS PR00061 RIBOSOMALL19 # PROSITE PS01015 RIBOSOMAL_L19 # Pfam PF01245 Ribosomal_L19 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RL19_ECOLI 50S ribosomal protein L19 # RefSeq NP_417097 NC_000913.3 # RefSeq WP_000065253 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein L19P family. {ECO 0000305}. # SUBUNIT RL19_ECOLI Part of the 50S ribosomal subunit. Contacts L14 (PubMed 2665813, PubMed 16272117). Forms two bridges to the 30S subunit in the 70S ribosome, contacting the 16S rRNA. {ECO 0000269|PubMed 16272117, ECO 0000269|PubMed 2665813}. # SUPFAM SSF50104 SSF50104 # TIGRFAMs TIGR01024 rplS_bact # eggNOG COG0335 LUCA # eggNOG ENOG4108YY1 Bacteria BLAST swissprot:RL19_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RL19_ECOLI BioCyc ECOL316407:JW2587-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2587-MONOMER BioCyc EcoCyc:EG10880-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10880-MONOMER BioCyc MetaCyc:EG10880-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10880-MONOMER COG COG0335 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0335 DIP DIP-35793N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35793N DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1016/S0092-8674(03)00427-6 http://dx.doi.org/10.1016/S0092-8674(03)00427-6 DOI 10.1016/j.celrep.2014.09.011 http://dx.doi.org/10.1016/j.celrep.2014.09.011 DOI 10.1021/bi00435a071 http://dx.doi.org/10.1021/bi00435a071 DOI 10.1021/bi00596a021 http://dx.doi.org/10.1021/bi00596a021 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pbio.1001866 http://dx.doi.org/10.1371/journal.pbio.1001866 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X01818 http://www.ebi.ac.uk/ena/data/view/X01818 EchoBASE EB0873 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0873 EcoGene EG10880 http://www.ecogene.org/geneInfo.php?eg_id=EG10880 EnsemblBacteria AAC75655 http://www.ensemblgenomes.org/id/AAC75655 EnsemblBacteria AAC75655 http://www.ensemblgenomes.org/id/AAC75655 EnsemblBacteria BAA16491 http://www.ensemblgenomes.org/id/BAA16491 EnsemblBacteria BAA16491 http://www.ensemblgenomes.org/id/BAA16491 EnsemblBacteria BAA16491 http://www.ensemblgenomes.org/id/BAA16491 EnsemblBacteria b2606 http://www.ensemblgenomes.org/id/b2606 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0022625 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022625 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GeneID 947096 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947096 HAMAP MF_00402 http://hamap.expasy.org/unirule/MF_00402 HOGENOM HOG000016264 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000016264&db=HOGENOM6 InParanoid P0A7K6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7K6 IntAct P0A7K6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7K6* InterPro IPR001857 http://www.ebi.ac.uk/interpro/entry/IPR001857 InterPro IPR008991 http://www.ebi.ac.uk/interpro/entry/IPR008991 InterPro IPR018257 http://www.ebi.ac.uk/interpro/entry/IPR018257 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW2587 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2587 KEGG_Gene eco:b2606 http://www.genome.jp/dbget-bin/www_bget?eco:b2606 KEGG_Orthology KO:K02884 http://www.genome.jp/dbget-bin/www_bget?KO:K02884 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 MINT MINT-1245288 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1245288 OMA EAEQCAK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EAEQCAK PANTHER PTHR15680 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15680 PDB 2J28 http://www.ebi.ac.uk/pdbe-srv/view/entry/2J28 PDB 2RDO http://www.ebi.ac.uk/pdbe-srv/view/entry/2RDO PDB 3BBX http://www.ebi.ac.uk/pdbe-srv/view/entry/3BBX PDB 3J5L http://www.ebi.ac.uk/pdbe-srv/view/entry/3J5L PDB 3J7Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J7Z PDB 3J8G http://www.ebi.ac.uk/pdbe-srv/view/entry/3J8G PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 4CSU http://www.ebi.ac.uk/pdbe-srv/view/entry/4CSU PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4UY8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4UY8 PDB 4V47 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V47 PDB 4V48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V48 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5ADY http://www.ebi.ac.uk/pdbe-srv/view/entry/5ADY PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5AKA http://www.ebi.ac.uk/pdbe-srv/view/entry/5AKA PDB 5GAD http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAD PDB 5GAE http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAE PDB 5GAF http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAF PDB 5GAG http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAG PDB 5GAH http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAH PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 2J28 http://www.ebi.ac.uk/pdbsum/2J28 PDBsum 2RDO http://www.ebi.ac.uk/pdbsum/2RDO PDBsum 3BBX http://www.ebi.ac.uk/pdbsum/3BBX PDBsum 3J5L http://www.ebi.ac.uk/pdbsum/3J5L PDBsum 3J7Z http://www.ebi.ac.uk/pdbsum/3J7Z PDBsum 3J8G http://www.ebi.ac.uk/pdbsum/3J8G PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 4CSU http://www.ebi.ac.uk/pdbsum/4CSU PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4UY8 http://www.ebi.ac.uk/pdbsum/4UY8 PDBsum 4V47 http://www.ebi.ac.uk/pdbsum/4V47 PDBsum 4V48 http://www.ebi.ac.uk/pdbsum/4V48 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5ADY http://www.ebi.ac.uk/pdbsum/5ADY PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5AKA http://www.ebi.ac.uk/pdbsum/5AKA PDBsum 5GAD http://www.ebi.ac.uk/pdbsum/5GAD PDBsum 5GAE http://www.ebi.ac.uk/pdbsum/5GAE PDBsum 5GAF http://www.ebi.ac.uk/pdbsum/5GAF PDBsum 5GAG http://www.ebi.ac.uk/pdbsum/5GAG PDBsum 5GAH http://www.ebi.ac.uk/pdbsum/5GAH PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PRINTS PR00061 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00061 PROSITE PS01015 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01015 PSORT swissprot:RL19_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RL19_ECOLI PSORT-B swissprot:RL19_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RL19_ECOLI PSORT2 swissprot:RL19_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RL19_ECOLI Pfam PF01245 http://pfam.xfam.org/family/PF01245 Phobius swissprot:RL19_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RL19_ECOLI PhylomeDB P0A7K6 http://phylomedb.org/?seqid=P0A7K6 ProteinModelPortal P0A7K6 http://www.proteinmodelportal.org/query/uniprot/P0A7K6 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 12809609 http://www.ncbi.nlm.nih.gov/pubmed/12809609 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 24844575 http://www.ncbi.nlm.nih.gov/pubmed/24844575 PubMed 25310980 http://www.ncbi.nlm.nih.gov/pubmed/25310980 PubMed 2665813 http://www.ncbi.nlm.nih.gov/pubmed/2665813 PubMed 339951 http://www.ncbi.nlm.nih.gov/pubmed/339951 PubMed 6357787 http://www.ncbi.nlm.nih.gov/pubmed/6357787 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417097 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417097 RefSeq WP_000065253 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000065253 SMR P0A7K6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7K6 STRING 511145.b2606 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2606&targetmode=cogs STRING COG0335 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0335&targetmode=cogs SUPFAM SSF50104 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50104 TIGRFAMs TIGR01024 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01024 UniProtKB RL19_ECOLI http://www.uniprot.org/uniprot/RL19_ECOLI UniProtKB-AC P0A7K6 http://www.uniprot.org/uniprot/P0A7K6 charge swissprot:RL19_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RL19_ECOLI eggNOG COG0335 http://eggnogapi.embl.de/nog_data/html/tree/COG0335 eggNOG ENOG4108YY1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108YY1 epestfind swissprot:RL19_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RL19_ECOLI garnier swissprot:RL19_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RL19_ECOLI helixturnhelix swissprot:RL19_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RL19_ECOLI hmoment swissprot:RL19_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RL19_ECOLI iep swissprot:RL19_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RL19_ECOLI inforesidue swissprot:RL19_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RL19_ECOLI octanol swissprot:RL19_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RL19_ECOLI pepcoil swissprot:RL19_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RL19_ECOLI pepdigest swissprot:RL19_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RL19_ECOLI pepinfo swissprot:RL19_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RL19_ECOLI pepnet swissprot:RL19_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RL19_ECOLI pepstats swissprot:RL19_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RL19_ECOLI pepwheel swissprot:RL19_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RL19_ECOLI pepwindow swissprot:RL19_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RL19_ECOLI sigcleave swissprot:RL19_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RL19_ECOLI ## Database ID URL or Descriptions # AltName Dimethylallyl diphosphate tRNA dimethylallyltransferase # AltName Isopentenyl-diphosphate tRNA isopentenyltransferase # BIOPHYSICOCHEMICAL PROPERTIES MIAA_ECOLI Kinetic parameters KM=96 nM for tRNA(Phe) {ECO 0000269|PubMed 9012675, ECO 0000269|PubMed 9148919}; KM=3.2 uM for DMAPP {ECO 0000269|PubMed 9012675, ECO 0000269|PubMed 9148919}; pH dependence Optimum pH is 6.5-9. {ECO 0000269|PubMed 9012675, ECO 0000269|PubMed 9148919}; # BioGrid 4263002 39 # CATALYTIC ACTIVITY MIAA_ECOLI Dimethylallyl diphosphate + adenine(37) in tRNA = diphosphate + N(6)-dimethylallyladenine(37) in tRNA. # COFACTOR MIAA_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 9012675}; # ENZYME REGULATION Strongly inhibited by ADP, ATP and other NTPs. {ECO:0000269|PubMed 9148919}. # EcoGene EG10595 miaA # FUNCTION MIAA_ECOLI Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A). {ECO 0000269|PubMed 9012675, ECO 0000269|PubMed 9148919}. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0052381 tRNA dimethylallyltransferase activity; IDA:EcoCyc. # GO_process GO:0006400 tRNA modification; IMP:EcoCyc. # GO_process GO:0034605 cellular response to heat; IMP:EcoCyc. # GOslim_function GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0006950 response to stress # Gene3D 3.40.50.300 -; 1. # HAMAP MF_00185 IPP_trans # INDUCTION MIAA_ECOLI By 2-aminopurine. # IntAct P16384 5 # InterPro IPR018022 IPP_trans # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01006 Prenyltransferases # KEGG_Brite ko03016 Transfer RNA biogenesis # KEGG_Pathway ko00908 Zeatin biosynthesis # MISCELLANEOUS MIAA_ECOLI Specific tRNA undermodification may be a switch to higher mutation frequency when cells are subject to environmental stresses other than treatment with mutagens. # Organism MIAA_ECOLI Escherichia coli (strain K12) # PATRIC 32123915 VBIEscCol129921_4302 # PDB 2ZM5 X-ray; 2.55 A; A/B=1-316 # PDB 2ZXU X-ray; 2.75 A; A/B=1-316 # PDB 3FOZ X-ray; 2.50 A; A/B=1-316 # PIR B37318 B37318 # Pfam PF01715 IPPT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MIAA_ECOLI tRNA dimethylallyltransferase # RefSeq NP_418592 NC_000913.3 # RefSeq WP_001280345 NZ_LN832404.1 # SIMILARITY Belongs to the IPP transferase family. {ECO 0000305}. # SUBUNIT MIAA_ECOLI Monomer. Binds to tRNA(Phe). {ECO 0000269|PubMed 19158097, ECO 0000269|PubMed 9012675, ECO 0000269|PubMed 9148919}. # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR00174 miaA # eggNOG COG0324 LUCA # eggNOG ENOG4105DKX Bacteria BLAST swissprot:MIAA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MIAA_ECOLI BioCyc ECOL316407:JW4129-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4129-MONOMER BioCyc EcoCyc:EG10595-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10595-MONOMER BioCyc MetaCyc:EG10595-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10595-MONOMER COG COG0324 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0324 DOI 10.1021/bi962225l http://dx.doi.org/10.1021/bi962225l DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.272.20.13073 http://dx.doi.org/10.1074/jbc.272.20.13073 DOI 10.1074/jbc.C800235200 http://dx.doi.org/10.1074/jbc.C800235200 DOI 10.1093/nar/19.5.1063 http://dx.doi.org/10.1093/nar/19.5.1063 DOI 10.1093/nar/20.9.2379 http://dx.doi.org/10.1093/nar/20.9.2379 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.5.1.75 http://www.genome.jp/dbget-bin/www_bget?EC:2.5.1.75 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D00743 http://www.ebi.ac.uk/ena/data/view/D00743 EMBL M63655 http://www.ebi.ac.uk/ena/data/view/M63655 EMBL U00005 http://www.ebi.ac.uk/ena/data/view/U00005 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL Z11831 http://www.ebi.ac.uk/ena/data/view/Z11831 ENZYME 2.5.1.75 http://enzyme.expasy.org/EC/2.5.1.75 EchoBASE EB0590 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0590 EcoGene EG10595 http://www.ecogene.org/geneInfo.php?eg_id=EG10595 EnsemblBacteria AAC77128 http://www.ensemblgenomes.org/id/AAC77128 EnsemblBacteria AAC77128 http://www.ensemblgenomes.org/id/AAC77128 EnsemblBacteria BAE78172 http://www.ensemblgenomes.org/id/BAE78172 EnsemblBacteria BAE78172 http://www.ensemblgenomes.org/id/BAE78172 EnsemblBacteria BAE78172 http://www.ensemblgenomes.org/id/BAE78172 EnsemblBacteria b4171 http://www.ensemblgenomes.org/id/b4171 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0052381 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052381 GO_process GO:0006400 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006400 GO_process GO:0034605 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034605 GOslim_function GO:0016765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016765 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948690 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948690 HAMAP MF_00185 http://hamap.expasy.org/unirule/MF_00185 HOGENOM HOG000039996 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000039996&db=HOGENOM6 InParanoid P16384 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P16384 IntAct P16384 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P16384* IntEnz 2.5.1.75 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.5.1.75 InterPro IPR018022 http://www.ebi.ac.uk/interpro/entry/IPR018022 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01006 http://www.genome.jp/dbget-bin/www_bget?ko01006 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW4129 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4129 KEGG_Gene eco:b4171 http://www.genome.jp/dbget-bin/www_bget?eco:b4171 KEGG_Orthology KO:K00791 http://www.genome.jp/dbget-bin/www_bget?KO:K00791 KEGG_Pathway ko00908 http://www.genome.jp/kegg-bin/show_pathway?ko00908 KEGG_Reaction rn:R01122 http://www.genome.jp/dbget-bin/www_bget?rn:R01122 OMA HTRNYAK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HTRNYAK PDB 2ZM5 http://www.ebi.ac.uk/pdbe-srv/view/entry/2ZM5 PDB 2ZXU http://www.ebi.ac.uk/pdbe-srv/view/entry/2ZXU PDB 3FOZ http://www.ebi.ac.uk/pdbe-srv/view/entry/3FOZ PDBsum 2ZM5 http://www.ebi.ac.uk/pdbsum/2ZM5 PDBsum 2ZXU http://www.ebi.ac.uk/pdbsum/2ZXU PDBsum 3FOZ http://www.ebi.ac.uk/pdbsum/3FOZ PSORT swissprot:MIAA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MIAA_ECOLI PSORT-B swissprot:MIAA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MIAA_ECOLI PSORT2 swissprot:MIAA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MIAA_ECOLI Pfam PF01715 http://pfam.xfam.org/family/PF01715 Phobius swissprot:MIAA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MIAA_ECOLI PhylomeDB P16384 http://phylomedb.org/?seqid=P16384 ProteinModelPortal P16384 http://www.proteinmodelportal.org/query/uniprot/P16384 PubMed 1594459 http://www.ncbi.nlm.nih.gov/pubmed/1594459 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19158097 http://www.ncbi.nlm.nih.gov/pubmed/19158097 PubMed 1999389 http://www.ncbi.nlm.nih.gov/pubmed/1999389 PubMed 2020545 http://www.ncbi.nlm.nih.gov/pubmed/2020545 PubMed 2656644 http://www.ncbi.nlm.nih.gov/pubmed/2656644 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9012675 http://www.ncbi.nlm.nih.gov/pubmed/9012675 PubMed 9148919 http://www.ncbi.nlm.nih.gov/pubmed/9148919 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418592 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418592 RefSeq WP_001280345 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001280345 SMR P16384 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P16384 STRING 511145.b4171 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4171&targetmode=cogs STRING COG0324 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0324&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR00174 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00174 UniProtKB MIAA_ECOLI http://www.uniprot.org/uniprot/MIAA_ECOLI UniProtKB-AC P16384 http://www.uniprot.org/uniprot/P16384 charge swissprot:MIAA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MIAA_ECOLI eggNOG COG0324 http://eggnogapi.embl.de/nog_data/html/tree/COG0324 eggNOG ENOG4105DKX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DKX epestfind swissprot:MIAA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MIAA_ECOLI garnier swissprot:MIAA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MIAA_ECOLI helixturnhelix swissprot:MIAA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MIAA_ECOLI hmoment swissprot:MIAA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MIAA_ECOLI iep swissprot:MIAA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MIAA_ECOLI inforesidue swissprot:MIAA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MIAA_ECOLI octanol swissprot:MIAA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MIAA_ECOLI pepcoil swissprot:MIAA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MIAA_ECOLI pepdigest swissprot:MIAA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MIAA_ECOLI pepinfo swissprot:MIAA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MIAA_ECOLI pepnet swissprot:MIAA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MIAA_ECOLI pepstats swissprot:MIAA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MIAA_ECOLI pepwheel swissprot:MIAA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MIAA_ECOLI pepwindow swissprot:MIAA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MIAA_ECOLI sigcleave swissprot:MIAA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MIAA_ECOLI ## Database ID URL or Descriptions # BioGrid 4263196 9 # CDD cd06261 TM_PBP2 # EcoGene EG13913 ycjP # FUNCTION YCJP_ECOLI Probably part of the binding-protein-dependent transport system YcjNOP. Probably responsible for the translocation of the substrate across the membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0055052 ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing; IBA:GO_Central. # GO_function GO:0022891 substrate-specific transmembrane transporter activity; IBA:GO_Central. # GO_process GO:0006810 transport; IBA:GO_Central. # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # Gene3D 1.10.3720.10 -; 1. # InterPro IPR000515 MetI-like # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00207 Putative multiple sugar transport system # KEGG_Brite ko02000 Transporters # Organism YCJP_ECOLI Escherichia coli (strain K12) # PATRIC 32117896 VBIEscCol129921_1368 # PIR C64880 C64880 # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCJP_ECOLI Inner membrane ABC transporter permease protein YcjP # RefSeq NP_415828 NC_000913.3 # RefSeq WP_000224659 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION YCJP_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF161098 SSF161098 # TCDB 3.A.1.1.46 the atp-binding cassette (abc) superfamily # eggNOG COG0395 LUCA # eggNOG ENOG4105DRW Bacteria BLAST swissprot:YCJP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCJP_ECOLI BioCyc ECOL316407:JW1305-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1305-MONOMER BioCyc EcoCyc:YCJP-MONOMER http://biocyc.org/getid?id=EcoCyc:YCJP-MONOMER COG COG0395 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0395 COG COG3833 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3833 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3672 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3672 EcoGene EG13913 http://www.ecogene.org/geneInfo.php?eg_id=EG13913 EnsemblBacteria AAC74394 http://www.ensemblgenomes.org/id/AAC74394 EnsemblBacteria AAC74394 http://www.ensemblgenomes.org/id/AAC74394 EnsemblBacteria BAA14888 http://www.ensemblgenomes.org/id/BAA14888 EnsemblBacteria BAA14888 http://www.ensemblgenomes.org/id/BAA14888 EnsemblBacteria BAA14888 http://www.ensemblgenomes.org/id/BAA14888 EnsemblBacteria b1312 http://www.ensemblgenomes.org/id/b1312 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0055052 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055052 GO_function GO:0022891 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022891 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 945892 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945892 HOGENOM HOG000220526 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220526&db=HOGENOM6 InParanoid P77716 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77716 InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1305 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1305 KEGG_Gene eco:b1312 http://www.genome.jp/dbget-bin/www_bget?eco:b1312 KEGG_Orthology KO:K02026 http://www.genome.jp/dbget-bin/www_bget?KO:K02026 OMA EKAAQMD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EKAAQMD PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:YCJP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCJP_ECOLI PSORT-B swissprot:YCJP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCJP_ECOLI PSORT2 swissprot:YCJP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCJP_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Phobius swissprot:YCJP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCJP_ECOLI PhylomeDB P77716 http://phylomedb.org/?seqid=P77716 ProteinModelPortal P77716 http://www.proteinmodelportal.org/query/uniprot/P77716 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415828 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415828 RefSeq WP_000224659 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000224659 SMR P77716 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77716 STRING 511145.b1312 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1312&targetmode=cogs STRING COG0395 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0395&targetmode=cogs STRING COG3833 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3833&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.1.46 http://www.tcdb.org/search/result.php?tc=3.A.1.1.46 UniProtKB YCJP_ECOLI http://www.uniprot.org/uniprot/YCJP_ECOLI UniProtKB-AC P77716 http://www.uniprot.org/uniprot/P77716 charge swissprot:YCJP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCJP_ECOLI eggNOG COG0395 http://eggnogapi.embl.de/nog_data/html/tree/COG0395 eggNOG ENOG4105DRW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DRW epestfind swissprot:YCJP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCJP_ECOLI garnier swissprot:YCJP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCJP_ECOLI helixturnhelix swissprot:YCJP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCJP_ECOLI hmoment swissprot:YCJP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCJP_ECOLI iep swissprot:YCJP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCJP_ECOLI inforesidue swissprot:YCJP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCJP_ECOLI octanol swissprot:YCJP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCJP_ECOLI pepcoil swissprot:YCJP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCJP_ECOLI pepdigest swissprot:YCJP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCJP_ECOLI pepinfo swissprot:YCJP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCJP_ECOLI pepnet swissprot:YCJP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCJP_ECOLI pepstats swissprot:YCJP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCJP_ECOLI pepwheel swissprot:YCJP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCJP_ECOLI pepwindow swissprot:YCJP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCJP_ECOLI sigcleave swissprot:YCJP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCJP_ECOLI ## Database ID URL or Descriptions # BioGrid 4260047 17 # EcoGene EG10473 hyaF # FUNCTION HYAF_ECOLI Not known. Could enhance the incorporation of nickel to the hydrogenase. # IntAct P19932 9 # InterPro IPR006894 HupH_Hydgase_express_prot_C # Organism HYAF_ECOLI Escherichia coli (strain K12) # PATRIC 32117175 VBIEscCol129921_1011 # PIR JV0077 QQECHF # Pfam PF04809 HupH_C; 2 # ProDom PD005668 PD005668; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HYAF_ECOLI Hydrogenase-1 operon protein HyaF # RefSeq NP_415496 NC_000913.3 # RefSeq WP_000004899 NZ_LN832404.1 # SIMILARITY Belongs to the HupH/HyaF family. {ECO 0000305}. # eggNOG ENOG4105MVP Bacteria # eggNOG ENOG4111IMM LUCA BLAST swissprot:HYAF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HYAF_ECOLI BioCyc ECOL316407:JW0959-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0959-MONOMER BioCyc EcoCyc:EG10473-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10473-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M34825 http://www.ebi.ac.uk/ena/data/view/M34825 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0468 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0468 EcoGene EG10473 http://www.ecogene.org/geneInfo.php?eg_id=EG10473 EnsemblBacteria AAC74062 http://www.ensemblgenomes.org/id/AAC74062 EnsemblBacteria AAC74062 http://www.ensemblgenomes.org/id/AAC74062 EnsemblBacteria BAA35742 http://www.ensemblgenomes.org/id/BAA35742 EnsemblBacteria BAA35742 http://www.ensemblgenomes.org/id/BAA35742 EnsemblBacteria BAA35742 http://www.ensemblgenomes.org/id/BAA35742 EnsemblBacteria b0977 http://www.ensemblgenomes.org/id/b0977 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945572 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945572 HOGENOM HOG000118840 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118840&db=HOGENOM6 InParanoid P19932 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P19932 IntAct P19932 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P19932* InterPro IPR006894 http://www.ebi.ac.uk/interpro/entry/IPR006894 KEGG_Gene ecj:JW0959 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0959 KEGG_Gene eco:b0977 http://www.genome.jp/dbget-bin/www_bget?eco:b0977 KEGG_Orthology KO:K03618 http://www.genome.jp/dbget-bin/www_bget?KO:K03618 OMA GYGSCRV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GYGSCRV PSORT swissprot:HYAF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HYAF_ECOLI PSORT-B swissprot:HYAF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HYAF_ECOLI PSORT2 swissprot:HYAF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HYAF_ECOLI Pfam PF04809 http://pfam.xfam.org/family/PF04809 Phobius swissprot:HYAF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HYAF_ECOLI PhylomeDB P19932 http://phylomedb.org/?seqid=P19932 ProteinModelPortal P19932 http://www.proteinmodelportal.org/query/uniprot/P19932 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2180913 http://www.ncbi.nlm.nih.gov/pubmed/2180913 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415496 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415496 RefSeq WP_000004899 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000004899 SMR P19932 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P19932 STRING 511145.b0977 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0977&targetmode=cogs UniProtKB HYAF_ECOLI http://www.uniprot.org/uniprot/HYAF_ECOLI UniProtKB-AC P19932 http://www.uniprot.org/uniprot/P19932 charge swissprot:HYAF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HYAF_ECOLI eggNOG ENOG4105MVP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105MVP eggNOG ENOG4111IMM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111IMM epestfind swissprot:HYAF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HYAF_ECOLI garnier swissprot:HYAF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HYAF_ECOLI helixturnhelix swissprot:HYAF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HYAF_ECOLI hmoment swissprot:HYAF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HYAF_ECOLI iep swissprot:HYAF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HYAF_ECOLI inforesidue swissprot:HYAF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HYAF_ECOLI octanol swissprot:HYAF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HYAF_ECOLI pepcoil swissprot:HYAF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HYAF_ECOLI pepdigest swissprot:HYAF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HYAF_ECOLI pepinfo swissprot:HYAF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HYAF_ECOLI pepnet swissprot:HYAF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HYAF_ECOLI pepstats swissprot:HYAF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HYAF_ECOLI pepwheel swissprot:HYAF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HYAF_ECOLI pepwindow swissprot:HYAF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HYAF_ECOLI sigcleave swissprot:HYAF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HYAF_ECOLI ## Database ID URL or Descriptions # BioGrid 4260196 3 # DISRUPTION PHENOTYPE Disruption of this gene induces 30 genes and represses 10 genes more than fourfold. It decreases biofilm formation, increases extracellular indole, leads to colanic acid overproduction and elicits mucoidy. {ECO:0000269|PubMed 18309357}. # EcoGene EG13773 mcbR # FUNCTION MCBR_ECOLI Important for biofilm formation. Represses expression of McbA by binding to its promoter region, which prevents colanic acid overproduction and mucoidy. {ECO 0000269|PubMed 18309357}. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # Gene3D 1.20.120.530 -; 1. # INDUCTION Induced by LsrR, LsrK, MqsR and TqsA. Repressed by LuxS and YgiV. {ECO:0000269|PubMed 18309357}. # IntAct P76114 11 # InterPro IPR000524 Tscrpt_reg_HTH_GntR # InterPro IPR008920 TF_FadR/GntR_C # InterPro IPR011711 GntR_C # InterPro IPR011991 WHTH_DNA-bd_dom # KEGG_Brite ko03000 Transcription factors # Organism MCBR_ECOLI Escherichia coli (strain K12) # PATRIC 32118192 VBIEscCol129921_1516 # PIR E64897 E64897 # PROSITE PS50949 HTH_GNTR # Pfam PF00392 GntR # Pfam PF07729 FCD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MCBR_ECOLI HTH-type transcriptional regulator McbR # RefSeq NP_415967 NC_000913.3 # RefSeq WP_001300742 NZ_LN832404.1 # SIMILARITY Contains 1 HTH gntR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00307}. # SMART SM00345 HTH_GNTR # SMART SM00895 FCD # SUPFAM SSF46785 SSF46785 # SUPFAM SSF48008 SSF48008 # eggNOG COG1802 LUCA # eggNOG ENOG4108WYP Bacteria BLAST swissprot:MCBR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MCBR_ECOLI BioCyc ECOL316407:JW1445-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1445-MONOMER BioCyc EcoCyc:G6761-MONOMER http://biocyc.org/getid?id=EcoCyc:G6761-MONOMER COG COG1802 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1802 DIP DIP-12749N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12749N DOI 10.1038/ismej.2008.24 http://dx.doi.org/10.1038/ismej.2008.24 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3535 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3535 EcoGene EG13773 http://www.ecogene.org/geneInfo.php?eg_id=EG13773 EnsemblBacteria AAC74532 http://www.ensemblgenomes.org/id/AAC74532 EnsemblBacteria AAC74532 http://www.ensemblgenomes.org/id/AAC74532 EnsemblBacteria BAA15082 http://www.ensemblgenomes.org/id/BAA15082 EnsemblBacteria BAA15082 http://www.ensemblgenomes.org/id/BAA15082 EnsemblBacteria BAA15082 http://www.ensemblgenomes.org/id/BAA15082 EnsemblBacteria b1450 http://www.ensemblgenomes.org/id/b1450 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 1.20.120.530 http://www.cathdb.info/version/latest/superfamily/1.20.120.530 GeneID 946014 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946014 HOGENOM HOG000273993 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000273993&db=HOGENOM6 InParanoid P76114 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76114 IntAct P76114 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76114* InterPro IPR000524 http://www.ebi.ac.uk/interpro/entry/IPR000524 InterPro IPR008920 http://www.ebi.ac.uk/interpro/entry/IPR008920 InterPro IPR011711 http://www.ebi.ac.uk/interpro/entry/IPR011711 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW1445 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1445 KEGG_Gene eco:b1450 http://www.genome.jp/dbget-bin/www_bget?eco:b1450 KEGG_Orthology KO:K13654 http://www.genome.jp/dbget-bin/www_bget?KO:K13654 MINT MINT-1303162 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1303162 OMA CRINEKE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CRINEKE PROSITE PS50949 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50949 PSORT swissprot:MCBR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MCBR_ECOLI PSORT-B swissprot:MCBR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MCBR_ECOLI PSORT2 swissprot:MCBR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MCBR_ECOLI Pfam PF00392 http://pfam.xfam.org/family/PF00392 Pfam PF07729 http://pfam.xfam.org/family/PF07729 Phobius swissprot:MCBR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MCBR_ECOLI PhylomeDB P76114 http://phylomedb.org/?seqid=P76114 ProteinModelPortal P76114 http://www.proteinmodelportal.org/query/uniprot/P76114 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18309357 http://www.ncbi.nlm.nih.gov/pubmed/18309357 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415967 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415967 RefSeq WP_001300742 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300742 SMART SM00345 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00345 SMART SM00895 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00895 SMR P76114 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76114 STRING 511145.b1450 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1450&targetmode=cogs STRING COG1802 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1802&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SUPFAM SSF48008 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48008 UniProtKB MCBR_ECOLI http://www.uniprot.org/uniprot/MCBR_ECOLI UniProtKB-AC P76114 http://www.uniprot.org/uniprot/P76114 charge swissprot:MCBR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MCBR_ECOLI eggNOG COG1802 http://eggnogapi.embl.de/nog_data/html/tree/COG1802 eggNOG ENOG4108WYP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108WYP epestfind swissprot:MCBR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MCBR_ECOLI garnier swissprot:MCBR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MCBR_ECOLI helixturnhelix swissprot:MCBR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MCBR_ECOLI hmoment swissprot:MCBR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MCBR_ECOLI iep swissprot:MCBR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MCBR_ECOLI inforesidue swissprot:MCBR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MCBR_ECOLI octanol swissprot:MCBR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MCBR_ECOLI pepcoil swissprot:MCBR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MCBR_ECOLI pepdigest swissprot:MCBR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MCBR_ECOLI pepinfo swissprot:MCBR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MCBR_ECOLI pepnet swissprot:MCBR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MCBR_ECOLI pepstats swissprot:MCBR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MCBR_ECOLI pepwheel swissprot:MCBR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MCBR_ECOLI pepwindow swissprot:MCBR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MCBR_ECOLI sigcleave swissprot:MCBR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MCBR_ECOLI ## Database ID URL or Descriptions # BioGrid 4261365 2 # EcoGene EG11601 sseB # FUNCTION SSEB_ECOLI May be involved in the enhancement of serine- sensitivity. # IntAct P0AFZ1 2 # InterPro IPR009839 SseB_N # InterPro IPR027945 SseB_C # Organism SSEB_ECOLI Escherichia coli (strain K12) # PATRIC 32120439 VBIEscCol129921_2622 # Pfam PF07179 SseB # Pfam PF14581 SseB_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SSEB_ECOLI Protein SseB # RefSeq NP_417017 NC_000913.3 # RefSeq WP_001295479 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA01383.1; Type=Frameshift; Positions=46; Evidence={ECO 0000305}; # eggNOG ENOG4105YYA Bacteria # eggNOG ENOG410XYP6 LUCA BLAST swissprot:SSEB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SSEB_ECOLI BioCyc ECOL316407:JW5404-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5404-MONOMER BioCyc EcoCyc:EG11601-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11601-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D10496 http://www.ebi.ac.uk/ena/data/view/D10496 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1558 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1558 EcoGene EG11601 http://www.ecogene.org/geneInfo.php?eg_id=EG11601 EnsemblBacteria AAC75575 http://www.ensemblgenomes.org/id/AAC75575 EnsemblBacteria AAC75575 http://www.ensemblgenomes.org/id/AAC75575 EnsemblBacteria BAA16412 http://www.ensemblgenomes.org/id/BAA16412 EnsemblBacteria BAA16412 http://www.ensemblgenomes.org/id/BAA16412 EnsemblBacteria BAA16412 http://www.ensemblgenomes.org/id/BAA16412 EnsemblBacteria b2522 http://www.ensemblgenomes.org/id/b2522 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946994 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946994 HOGENOM HOG000123480 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000123480&db=HOGENOM6 InParanoid P0AFZ1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFZ1 IntAct P0AFZ1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFZ1* InterPro IPR009839 http://www.ebi.ac.uk/interpro/entry/IPR009839 InterPro IPR027945 http://www.ebi.ac.uk/interpro/entry/IPR027945 KEGG_Gene ecj:JW5404 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5404 KEGG_Gene eco:b2522 http://www.genome.jp/dbget-bin/www_bget?eco:b2522 OMA WEKDDGT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WEKDDGT PSORT swissprot:SSEB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SSEB_ECOLI PSORT-B swissprot:SSEB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SSEB_ECOLI PSORT2 swissprot:SSEB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SSEB_ECOLI Pfam PF07179 http://pfam.xfam.org/family/PF07179 Pfam PF14581 http://pfam.xfam.org/family/PF14581 Phobius swissprot:SSEB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SSEB_ECOLI ProteinModelPortal P0AFZ1 http://www.proteinmodelportal.org/query/uniprot/P0AFZ1 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7982894 http://www.ncbi.nlm.nih.gov/pubmed/7982894 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417017 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417017 RefSeq WP_001295479 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295479 STRING 511145.b2522 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2522&targetmode=cogs UniProtKB SSEB_ECOLI http://www.uniprot.org/uniprot/SSEB_ECOLI UniProtKB-AC P0AFZ1 http://www.uniprot.org/uniprot/P0AFZ1 charge swissprot:SSEB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SSEB_ECOLI eggNOG ENOG4105YYA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105YYA eggNOG ENOG410XYP6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XYP6 epestfind swissprot:SSEB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SSEB_ECOLI garnier swissprot:SSEB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SSEB_ECOLI helixturnhelix swissprot:SSEB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SSEB_ECOLI hmoment swissprot:SSEB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SSEB_ECOLI iep swissprot:SSEB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SSEB_ECOLI inforesidue swissprot:SSEB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SSEB_ECOLI octanol swissprot:SSEB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SSEB_ECOLI pepcoil swissprot:SSEB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SSEB_ECOLI pepdigest swissprot:SSEB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SSEB_ECOLI pepinfo swissprot:SSEB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SSEB_ECOLI pepnet swissprot:SSEB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SSEB_ECOLI pepstats swissprot:SSEB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SSEB_ECOLI pepwheel swissprot:SSEB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SSEB_ECOLI pepwindow swissprot:SSEB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SSEB_ECOLI sigcleave swissprot:SSEB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SSEB_ECOLI ## Database ID URL or Descriptions # BioGrid 4263233 299 # EcoGene EG10777 pspB # FUNCTION PSPB_ECOLI The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions. PspB is involved in transcription regulation. {ECO 0000269|PubMed 1712397}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:InterPro. # GO_process GO:0009271 phage shock; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0044403 symbiosis, encompassing mutualism through parasitism # INDUCTION By heat, ethanol, osmotic shock and infection by filamentous bacteriophages. {ECO:0000269|PubMed 1712397}. # InterPro IPR009554 Phageshock_PspB # Organism PSPB_ECOLI Escherichia coli (strain K12) # PATRIC 32117882 VBIEscCol129921_1361 # PIR S17122 S17122 # Pfam PF06667 PspB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PSPB_ECOLI Phage shock protein B # RefSeq NP_415821 NC_000913.3 # RefSeq WP_001274963 NZ_LN832404.1 # SIMILARITY Belongs to the PspB family. {ECO 0000305}. # SUBCELLULAR LOCATION PSPB_ECOLI Cell inner membrane; Single-pass membrane protein. # SUBUNIT Interacts with PspA; could bind PspA only in the presence of PspC. {ECO:0000269|PubMed 12562786}. # TIGRFAMs TIGR02976 phageshock_pspB # eggNOG ENOG4105YYT Bacteria # eggNOG ENOG41123WF LUCA BLAST swissprot:PSPB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PSPB_ECOLI BioCyc ECOL316407:JW1298-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1298-MONOMER BioCyc EcoCyc:EG10777-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10777-MONOMER DIP DIP-10588N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10588N DOI 10.1016/0022-2836(91)90379-K http://dx.doi.org/10.1016/0022-2836(91)90379-K DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.185.4.1174-1180.2003 http://dx.doi.org/10.1128/JB.185.4.1174-1180.2003 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X57560 http://www.ebi.ac.uk/ena/data/view/X57560 EchoBASE EB0770 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0770 EcoGene EG10777 http://www.ecogene.org/geneInfo.php?eg_id=EG10777 EnsemblBacteria AAC74387 http://www.ensemblgenomes.org/id/AAC74387 EnsemblBacteria AAC74387 http://www.ensemblgenomes.org/id/AAC74387 EnsemblBacteria BAA14874 http://www.ensemblgenomes.org/id/BAA14874 EnsemblBacteria BAA14874 http://www.ensemblgenomes.org/id/BAA14874 EnsemblBacteria BAA14874 http://www.ensemblgenomes.org/id/BAA14874 EnsemblBacteria b1305 http://www.ensemblgenomes.org/id/b1305 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0009271 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009271 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0044403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403 GeneID 945893 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945893 HOGENOM HOG000276514 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276514&db=HOGENOM6 IntAct P0AFM9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFM9* InterPro IPR009554 http://www.ebi.ac.uk/interpro/entry/IPR009554 KEGG_Gene ecj:JW1298 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1298 KEGG_Gene eco:b1305 http://www.genome.jp/dbget-bin/www_bget?eco:b1305 KEGG_Orthology KO:K03970 http://www.genome.jp/dbget-bin/www_bget?KO:K03970 OMA LWLHYSQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LWLHYSQ PSORT swissprot:PSPB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PSPB_ECOLI PSORT-B swissprot:PSPB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PSPB_ECOLI PSORT2 swissprot:PSPB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PSPB_ECOLI Pfam PF06667 http://pfam.xfam.org/family/PF06667 Phobius swissprot:PSPB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PSPB_ECOLI ProteinModelPortal P0AFM9 http://www.proteinmodelportal.org/query/uniprot/P0AFM9 PubMed 12562786 http://www.ncbi.nlm.nih.gov/pubmed/12562786 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1712397 http://www.ncbi.nlm.nih.gov/pubmed/1712397 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415821 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415821 RefSeq WP_001274963 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001274963 STRING 511145.b1305 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1305&targetmode=cogs TIGRFAMs TIGR02976 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02976 UniProtKB PSPB_ECOLI http://www.uniprot.org/uniprot/PSPB_ECOLI UniProtKB-AC P0AFM9 http://www.uniprot.org/uniprot/P0AFM9 charge swissprot:PSPB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PSPB_ECOLI eggNOG ENOG4105YYT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105YYT eggNOG ENOG41123WF http://eggnogapi.embl.de/nog_data/html/tree/ENOG41123WF epestfind swissprot:PSPB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PSPB_ECOLI garnier swissprot:PSPB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PSPB_ECOLI helixturnhelix swissprot:PSPB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PSPB_ECOLI hmoment swissprot:PSPB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PSPB_ECOLI iep swissprot:PSPB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PSPB_ECOLI inforesidue swissprot:PSPB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PSPB_ECOLI octanol swissprot:PSPB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PSPB_ECOLI pepcoil swissprot:PSPB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PSPB_ECOLI pepdigest swissprot:PSPB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PSPB_ECOLI pepinfo swissprot:PSPB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PSPB_ECOLI pepnet swissprot:PSPB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PSPB_ECOLI pepstats swissprot:PSPB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PSPB_ECOLI pepwheel swissprot:PSPB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PSPB_ECOLI pepwindow swissprot:PSPB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PSPB_ECOLI sigcleave swissprot:PSPB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PSPB_ECOLI ## Database ID URL or Descriptions # BioGrid 4259553 304 # COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI 18420; Note=Binds 1 Mg(2+) ion per subunit.; # EcoGene EG10150 cheY # FUNCTION CHEY_ECOLI Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. In its active (phosphorylated or acetylated) form, CheY exhibits enhanced binding to a switch component, FliM, at the flagellar motor which induces a change from counterclockwise to clockwise flagellar rotation. Overexpression of CheY in association with MotA and MotB improves motility of a ycgR disruption, suggesting there is an interaction (direct or indirect) between the c-di-GMP-binding flagellar brake protein and the flagellar stator. {ECO 0000269|PubMed 20346719}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IMP:EcoCyc. # GO_function GO:0016407 acetyltransferase activity; IDA:CACAO. # GO_process GO:0000160 phosphorelay signal transduction system; IDA:EcoCyc. # GO_process GO:0006473 protein acetylation; IDA:EcoCyc. # GO_process GO:0006935 chemotaxis; IMP:EcoCyc. # GO_process GO:0018393 internal peptidyl-lysine acetylation; IMP:CACAO. # GO_process GO:0071973 bacterial-type flagellum-dependent cell motility; TAS:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0040011 locomotion # GOslim_process GO:0048870 cell motility # INTERACTION CHEY_ECOLI P07363 cheA; NbExp=3; IntAct=EBI-546693, EBI-1026773; P0A9H9 cheZ; NbExp=3; IntAct=EBI-546693, EBI-546726; # IntAct P0AE67 12 # InterPro IPR001789 Sig_transdc_resp-reg_receiver # InterPro IPR011006 CheY-like_superfamily # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02022 M00506 CheA-CheYBV (chemotaxis) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Brite ko02030 M00506 CheA-CheYBV (chemotaxis) two-component regulatory system # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Brite ko02035 M00506 CheA-CheYBV (chemotaxis) two-component regulatory system # KEGG_Pathway ko02020 Two-component system # KEGG_Pathway ko02030 Bacterial chemotaxis # MASS SPECTROMETRY Mass=13966; Method=Electrospray; Range=2-129; Evidence={ECO:0000269|PubMed 9560203}; # MASS SPECTROMETRY Mass=14008; Method=Electrospray; Range=2-129; Note=With N6-acetyl-Lys-92.; Evidence={ECO:0000269|PubMed 9560203}; # Organism CHEY_ECOLI Escherichia coli (strain K12) # PATRIC 32119091 VBIEscCol129921_1963 # PDB 1A0O X-ray; 2.95 A; A/C/E/G=2-129 # PDB 1AB5 X-ray; 2.40 A; A/B=5-129 # PDB 1AB6 X-ray; 2.20 A; A/B=5-129 # PDB 1BDJ X-ray; 2.68 A; A=2-129 # PDB 1C4W X-ray; 1.84 A; A=2-129 # PDB 1CEY NMR; -; A=2-129 # PDB 1CHN X-ray; 1.76 A; A=2-129 # PDB 1CYE NMR; -; A=3-129 # PDB 1D4Z X-ray; 1.90 A; A=2-129 # PDB 1DJM NMR; -; A=1-129 # PDB 1E6K X-ray; 2.00 A; A=3-129 # PDB 1E6L X-ray; 1.90 A; A=3-129 # PDB 1E6M X-ray; 1.70 A; A=3-129 # PDB 1EAY X-ray; 2.00 A; A/B=2-129 # PDB 1EHC X-ray; 2.26 A; A=2-129 # PDB 1F4V X-ray; 2.22 A; A/B/C=2-129 # PDB 1FFG X-ray; 2.10 A; A/C=2-129 # PDB 1FFS X-ray; 2.40 A; A/C=2-129 # PDB 1FFW X-ray; 2.70 A; A/C=2-129 # PDB 1FQW X-ray; 2.37 A; A/B=2-129 # PDB 1HEY X-ray; 2.24 A; A=2-129 # PDB 1JBE X-ray; 1.08 A; A=2-129 # PDB 1KMI X-ray; 2.90 A; Y=1-129 # PDB 1MIH X-ray; 2.70 A; A/B=1-129 # PDB 1U8T X-ray; 1.50 A; A/B/C/D=2-129 # PDB 1UDR X-ray; 1.90 A; A/B/C/D=1-129 # PDB 1VLZ X-ray; 2.05 A; A/B=2-129 # PDB 1YMU X-ray; 2.30 A; A/B=3-129 # PDB 1YMV X-ray; 1.90 A; A=3-129 # PDB 1ZDM X-ray; 2.40 A; A/B=1-129 # PDB 2B1J X-ray; 2.40 A; A/B=2-129 # PDB 2ID7 X-ray; 1.75 A; A=2-129 # PDB 2ID9 X-ray; 1.75 A; A=2-129 # PDB 2IDM X-ray; 2.00 A; A=2-129 # PDB 2LP4 NMR; -; Y=2-129 # PDB 3CHY X-ray; 1.66 A; A=2-129 # PDB 3F7N X-ray; 2.00 A; A/B=2-129 # PDB 3FFT X-ray; 2.21 A; A/B=2-129 # PDB 3FFW X-ray; 2.00 A; A/B=2-129 # PDB 3FFX X-ray; 2.01 A; A/B=2-129 # PDB 3FGZ X-ray; 2.00 A; A/B=2-129 # PDB 3MYY X-ray; 2.10 A; A/B=2-129 # PDB 3OLV X-ray; 1.70 A; A/B=1-129 # PDB 3OLW X-ray; 2.30 A; A/B=1-129 # PDB 3OLX X-ray; 2.10 A; A/B=1-129 # PDB 3OLY X-ray; 2.05 A; A/B=1-129 # PDB 3OO0 X-ray; 1.55 A; A/B=1-129 # PDB 3OO1 X-ray; 1.70 A; A/B=1-129 # PDB 3RVJ X-ray; 2.10 A; A/B=1-129 # PDB 3RVK X-ray; 1.16 A; A=1-129 # PDB 3RVL X-ray; 1.55 A; A/B=1-129 # PDB 3RVM X-ray; 1.45 A; A=1-129 # PDB 3RVN X-ray; 2.25 A; A/B=1-129 # PDB 3RVO X-ray; 1.55 A; A=1-129 # PDB 3RVP X-ray; 2.40 A; A/B=1-129 # PDB 3RVQ X-ray; 1.15 A; A=1-129 # PDB 3RVR X-ray; 2.10 A; A/B=1-129 # PDB 3RVS X-ray; 2.10 A; A/B=1-129 # PDB 5CHY X-ray; 2.00 A; A=2-129 # PDB 5D2C X-ray; 2.06 A; A/B=2-129 # PDB 5DGC X-ray; 1.94 A; A/B=2-129 # PDB 5DKF X-ray; 1.94 A; A/B=2-129 # PDB 6CHY X-ray; 2.33 A; A/B=2-129 # PIR E25195 QRECCY # PROSITE PS50110 RESPONSE_REGULATORY # PTM CHEY_ECOLI Phosphorylated by CheA or acetylated by acetyl-CoA synthetase, depending on which acetate metabolism pathway is available. The major acetylation site seems to be Lys-92. Dephosphorylated (inactivated) by CheZ. {ECO 0000269|PubMed 1390767, ECO 0000269|PubMed 2689446, ECO 0000269|PubMed 3280143, ECO 0000269|PubMed 9560203}. # Pfam PF00072 Response_reg # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CHEY_ECOLI Chemotaxis protein CheY # RefSeq NP_416396 NC_000913.3 # RefSeq WP_000763867 NZ_LN832404.1 # SIMILARITY Contains 1 response regulatory domain. {ECO:0000255|PROSITE-ProRule PRU00169}. # SMART SM00448 REC # SUBCELLULAR LOCATION CHEY_ECOLI Cytoplasm. # SUBUNIT CHEY_ECOLI Interacts (phosphorylated CheY) with CheZ (via C- terminus). {ECO 0000269|PubMed 12080332, ECO 0000269|PubMed 9437425}. # SUPFAM SSF52172 SSF52172 # eggNOG COG0784 LUCA # eggNOG ENOG4108VYJ Bacteria BLAST swissprot:CHEY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CHEY_ECOLI BioCyc ECOL316407:JW1871-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1871-MONOMER BioCyc EcoCyc:CHEY-MONOMER http://biocyc.org/getid?id=EcoCyc:CHEY-MONOMER COG COG0784 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0784 DIP DIP-6052N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-6052N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/jmbi.1994.1308 http://dx.doi.org/10.1006/jmbi.1994.1308 DOI 10.1006/jmbi.1996.0151 http://dx.doi.org/10.1006/jmbi.1996.0151 DOI 10.1006/jmbi.2000.3595 http://dx.doi.org/10.1006/jmbi.2000.3595 DOI 10.1006/jmbi.2000.4507 http://dx.doi.org/10.1006/jmbi.2000.4507 DOI 10.1016/0092-8674(88)90489-8 http://dx.doi.org/10.1016/0092-8674(88)90489-8 DOI 10.1016/j.molcel.2010.03.001 http://dx.doi.org/10.1016/j.molcel.2010.03.001 DOI 10.1021/bi00156a033 http://dx.doi.org/10.1021/bi00156a033 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb0198-25 http://dx.doi.org/10.1038/nsb0198-25 DOI 10.1038/nsb816 http://dx.doi.org/10.1038/nsb816 DOI 10.1046/j.1365-2958.1996.393934.x http://dx.doi.org/10.1046/j.1365-2958.1996.393934.x DOI 10.1046/j.1365-2958.2001.02425.x http://dx.doi.org/10.1046/j.1365-2958.2001.02425.x DOI 10.1073/pnas.95.13.7333 http://dx.doi.org/10.1073/pnas.95.13.7333 DOI 10.1073/pnas.95.9.4918 http://dx.doi.org/10.1073/pnas.95.9.4918 DOI 10.1074/jbc.272.8.5000 http://dx.doi.org/10.1074/jbc.272.8.5000 DOI 10.1074/jbc.M704400200 http://dx.doi.org/10.1074/jbc.M704400200 DOI 10.1074/jbc.M909908199 http://dx.doi.org/10.1074/jbc.M909908199 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1107/S0907444997007075 http://dx.doi.org/10.1107/S0907444997007075 DOI 10.1107/S0907444997012158 http://dx.doi.org/10.1107/S0907444997012158 DOI 10.1111/j.1432-1033.1993.tb18068.x http://dx.doi.org/10.1111/j.1432-1033.1993.tb18068.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K02175 http://www.ebi.ac.uk/ena/data/view/K02175 EMBL M13463 http://www.ebi.ac.uk/ena/data/view/M13463 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0148 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0148 EcoGene EG10150 http://www.ecogene.org/geneInfo.php?eg_id=EG10150 EnsemblBacteria AAC74952 http://www.ensemblgenomes.org/id/AAC74952 EnsemblBacteria AAC74952 http://www.ensemblgenomes.org/id/AAC74952 EnsemblBacteria BAA15698 http://www.ensemblgenomes.org/id/BAA15698 EnsemblBacteria BAA15698 http://www.ensemblgenomes.org/id/BAA15698 EnsemblBacteria BAA15698 http://www.ensemblgenomes.org/id/BAA15698 EnsemblBacteria b1882 http://www.ensemblgenomes.org/id/b1882 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0016407 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016407 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006473 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006473 GO_process GO:0006935 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006935 GO_process GO:0018393 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018393 GO_process GO:0071973 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071973 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0040011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 GeneID 946393 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946393 HOGENOM HOG000034820 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000034820&db=HOGENOM6 InParanoid P0AE67 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AE67 IntAct P0AE67 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AE67* InterPro IPR001789 http://www.ebi.ac.uk/interpro/entry/IPR001789 InterPro IPR011006 http://www.ebi.ac.uk/interpro/entry/IPR011006 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02030 http://www.genome.jp/dbget-bin/www_bget?ko02030 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW1871 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1871 KEGG_Gene eco:b1882 http://www.genome.jp/dbget-bin/www_bget?eco:b1882 KEGG_Orthology KO:K03413 http://www.genome.jp/dbget-bin/www_bget?KO:K03413 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 KEGG_Pathway ko02030 http://www.genome.jp/kegg-bin/show_pathway?ko02030 OMA MLQSGAF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MLQSGAF PDB 1A0O http://www.ebi.ac.uk/pdbe-srv/view/entry/1A0O PDB 1AB5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1AB5 PDB 1AB6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1AB6 PDB 1BDJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1BDJ PDB 1C4W http://www.ebi.ac.uk/pdbe-srv/view/entry/1C4W PDB 1CEY http://www.ebi.ac.uk/pdbe-srv/view/entry/1CEY PDB 1CHN http://www.ebi.ac.uk/pdbe-srv/view/entry/1CHN PDB 1CYE http://www.ebi.ac.uk/pdbe-srv/view/entry/1CYE PDB 1D4Z http://www.ebi.ac.uk/pdbe-srv/view/entry/1D4Z PDB 1DJM http://www.ebi.ac.uk/pdbe-srv/view/entry/1DJM PDB 1E6K http://www.ebi.ac.uk/pdbe-srv/view/entry/1E6K PDB 1E6L http://www.ebi.ac.uk/pdbe-srv/view/entry/1E6L PDB 1E6M http://www.ebi.ac.uk/pdbe-srv/view/entry/1E6M PDB 1EAY http://www.ebi.ac.uk/pdbe-srv/view/entry/1EAY PDB 1EHC http://www.ebi.ac.uk/pdbe-srv/view/entry/1EHC PDB 1F4V http://www.ebi.ac.uk/pdbe-srv/view/entry/1F4V PDB 1FFG http://www.ebi.ac.uk/pdbe-srv/view/entry/1FFG PDB 1FFS http://www.ebi.ac.uk/pdbe-srv/view/entry/1FFS PDB 1FFW http://www.ebi.ac.uk/pdbe-srv/view/entry/1FFW PDB 1FQW http://www.ebi.ac.uk/pdbe-srv/view/entry/1FQW PDB 1HEY http://www.ebi.ac.uk/pdbe-srv/view/entry/1HEY PDB 1JBE http://www.ebi.ac.uk/pdbe-srv/view/entry/1JBE PDB 1KMI http://www.ebi.ac.uk/pdbe-srv/view/entry/1KMI PDB 1MIH http://www.ebi.ac.uk/pdbe-srv/view/entry/1MIH PDB 1U8T http://www.ebi.ac.uk/pdbe-srv/view/entry/1U8T PDB 1UDR http://www.ebi.ac.uk/pdbe-srv/view/entry/1UDR PDB 1VLZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1VLZ PDB 1YMU http://www.ebi.ac.uk/pdbe-srv/view/entry/1YMU PDB 1YMV http://www.ebi.ac.uk/pdbe-srv/view/entry/1YMV PDB 1ZDM http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZDM PDB 2B1J http://www.ebi.ac.uk/pdbe-srv/view/entry/2B1J PDB 2ID7 http://www.ebi.ac.uk/pdbe-srv/view/entry/2ID7 PDB 2ID9 http://www.ebi.ac.uk/pdbe-srv/view/entry/2ID9 PDB 2IDM http://www.ebi.ac.uk/pdbe-srv/view/entry/2IDM PDB 2LP4 http://www.ebi.ac.uk/pdbe-srv/view/entry/2LP4 PDB 3CHY http://www.ebi.ac.uk/pdbe-srv/view/entry/3CHY PDB 3F7N http://www.ebi.ac.uk/pdbe-srv/view/entry/3F7N PDB 3FFT http://www.ebi.ac.uk/pdbe-srv/view/entry/3FFT PDB 3FFW http://www.ebi.ac.uk/pdbe-srv/view/entry/3FFW PDB 3FFX http://www.ebi.ac.uk/pdbe-srv/view/entry/3FFX PDB 3FGZ http://www.ebi.ac.uk/pdbe-srv/view/entry/3FGZ PDB 3MYY http://www.ebi.ac.uk/pdbe-srv/view/entry/3MYY PDB 3OLV http://www.ebi.ac.uk/pdbe-srv/view/entry/3OLV PDB 3OLW http://www.ebi.ac.uk/pdbe-srv/view/entry/3OLW PDB 3OLX http://www.ebi.ac.uk/pdbe-srv/view/entry/3OLX PDB 3OLY http://www.ebi.ac.uk/pdbe-srv/view/entry/3OLY PDB 3OO0 http://www.ebi.ac.uk/pdbe-srv/view/entry/3OO0 PDB 3OO1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3OO1 PDB 3RVJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3RVJ PDB 3RVK http://www.ebi.ac.uk/pdbe-srv/view/entry/3RVK PDB 3RVL http://www.ebi.ac.uk/pdbe-srv/view/entry/3RVL PDB 3RVM http://www.ebi.ac.uk/pdbe-srv/view/entry/3RVM PDB 3RVN http://www.ebi.ac.uk/pdbe-srv/view/entry/3RVN PDB 3RVO http://www.ebi.ac.uk/pdbe-srv/view/entry/3RVO PDB 3RVP http://www.ebi.ac.uk/pdbe-srv/view/entry/3RVP PDB 3RVQ http://www.ebi.ac.uk/pdbe-srv/view/entry/3RVQ PDB 3RVR http://www.ebi.ac.uk/pdbe-srv/view/entry/3RVR PDB 3RVS http://www.ebi.ac.uk/pdbe-srv/view/entry/3RVS PDB 5CHY http://www.ebi.ac.uk/pdbe-srv/view/entry/5CHY PDB 5D2C http://www.ebi.ac.uk/pdbe-srv/view/entry/5D2C PDB 5DGC http://www.ebi.ac.uk/pdbe-srv/view/entry/5DGC PDB 5DKF http://www.ebi.ac.uk/pdbe-srv/view/entry/5DKF PDB 6CHY http://www.ebi.ac.uk/pdbe-srv/view/entry/6CHY PDBsum 1A0O http://www.ebi.ac.uk/pdbsum/1A0O PDBsum 1AB5 http://www.ebi.ac.uk/pdbsum/1AB5 PDBsum 1AB6 http://www.ebi.ac.uk/pdbsum/1AB6 PDBsum 1BDJ http://www.ebi.ac.uk/pdbsum/1BDJ PDBsum 1C4W http://www.ebi.ac.uk/pdbsum/1C4W PDBsum 1CEY http://www.ebi.ac.uk/pdbsum/1CEY PDBsum 1CHN http://www.ebi.ac.uk/pdbsum/1CHN PDBsum 1CYE http://www.ebi.ac.uk/pdbsum/1CYE PDBsum 1D4Z http://www.ebi.ac.uk/pdbsum/1D4Z PDBsum 1DJM http://www.ebi.ac.uk/pdbsum/1DJM PDBsum 1E6K http://www.ebi.ac.uk/pdbsum/1E6K PDBsum 1E6L http://www.ebi.ac.uk/pdbsum/1E6L PDBsum 1E6M http://www.ebi.ac.uk/pdbsum/1E6M PDBsum 1EAY http://www.ebi.ac.uk/pdbsum/1EAY PDBsum 1EHC http://www.ebi.ac.uk/pdbsum/1EHC PDBsum 1F4V http://www.ebi.ac.uk/pdbsum/1F4V PDBsum 1FFG http://www.ebi.ac.uk/pdbsum/1FFG PDBsum 1FFS http://www.ebi.ac.uk/pdbsum/1FFS PDBsum 1FFW http://www.ebi.ac.uk/pdbsum/1FFW PDBsum 1FQW http://www.ebi.ac.uk/pdbsum/1FQW PDBsum 1HEY http://www.ebi.ac.uk/pdbsum/1HEY PDBsum 1JBE http://www.ebi.ac.uk/pdbsum/1JBE PDBsum 1KMI http://www.ebi.ac.uk/pdbsum/1KMI PDBsum 1MIH http://www.ebi.ac.uk/pdbsum/1MIH PDBsum 1U8T http://www.ebi.ac.uk/pdbsum/1U8T PDBsum 1UDR http://www.ebi.ac.uk/pdbsum/1UDR PDBsum 1VLZ http://www.ebi.ac.uk/pdbsum/1VLZ PDBsum 1YMU http://www.ebi.ac.uk/pdbsum/1YMU PDBsum 1YMV http://www.ebi.ac.uk/pdbsum/1YMV PDBsum 1ZDM http://www.ebi.ac.uk/pdbsum/1ZDM PDBsum 2B1J http://www.ebi.ac.uk/pdbsum/2B1J PDBsum 2ID7 http://www.ebi.ac.uk/pdbsum/2ID7 PDBsum 2ID9 http://www.ebi.ac.uk/pdbsum/2ID9 PDBsum 2IDM http://www.ebi.ac.uk/pdbsum/2IDM PDBsum 2LP4 http://www.ebi.ac.uk/pdbsum/2LP4 PDBsum 3CHY http://www.ebi.ac.uk/pdbsum/3CHY PDBsum 3F7N http://www.ebi.ac.uk/pdbsum/3F7N PDBsum 3FFT http://www.ebi.ac.uk/pdbsum/3FFT PDBsum 3FFW http://www.ebi.ac.uk/pdbsum/3FFW PDBsum 3FFX http://www.ebi.ac.uk/pdbsum/3FFX PDBsum 3FGZ http://www.ebi.ac.uk/pdbsum/3FGZ PDBsum 3MYY http://www.ebi.ac.uk/pdbsum/3MYY PDBsum 3OLV http://www.ebi.ac.uk/pdbsum/3OLV PDBsum 3OLW http://www.ebi.ac.uk/pdbsum/3OLW PDBsum 3OLX http://www.ebi.ac.uk/pdbsum/3OLX PDBsum 3OLY http://www.ebi.ac.uk/pdbsum/3OLY PDBsum 3OO0 http://www.ebi.ac.uk/pdbsum/3OO0 PDBsum 3OO1 http://www.ebi.ac.uk/pdbsum/3OO1 PDBsum 3RVJ http://www.ebi.ac.uk/pdbsum/3RVJ PDBsum 3RVK http://www.ebi.ac.uk/pdbsum/3RVK PDBsum 3RVL http://www.ebi.ac.uk/pdbsum/3RVL PDBsum 3RVM http://www.ebi.ac.uk/pdbsum/3RVM PDBsum 3RVN http://www.ebi.ac.uk/pdbsum/3RVN PDBsum 3RVO http://www.ebi.ac.uk/pdbsum/3RVO PDBsum 3RVP http://www.ebi.ac.uk/pdbsum/3RVP PDBsum 3RVQ http://www.ebi.ac.uk/pdbsum/3RVQ PDBsum 3RVR http://www.ebi.ac.uk/pdbsum/3RVR PDBsum 3RVS http://www.ebi.ac.uk/pdbsum/3RVS PDBsum 5CHY http://www.ebi.ac.uk/pdbsum/5CHY PDBsum 5D2C http://www.ebi.ac.uk/pdbsum/5D2C PDBsum 5DGC http://www.ebi.ac.uk/pdbsum/5DGC PDBsum 5DKF http://www.ebi.ac.uk/pdbsum/5DKF PDBsum 6CHY http://www.ebi.ac.uk/pdbsum/6CHY PROSITE PS50110 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50110 PSORT swissprot:CHEY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CHEY_ECOLI PSORT-B swissprot:CHEY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CHEY_ECOLI PSORT2 swissprot:CHEY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CHEY_ECOLI Pfam PF00072 http://pfam.xfam.org/family/PF00072 Phobius swissprot:CHEY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CHEY_ECOLI PhylomeDB P0AE67 http://phylomedb.org/?seqid=P0AE67 ProteinModelPortal P0AE67 http://www.proteinmodelportal.org/query/uniprot/P0AE67 PubMed 10731410 http://www.ncbi.nlm.nih.gov/pubmed/10731410 PubMed 10748173 http://www.ncbi.nlm.nih.gov/pubmed/10748173 PubMed 11023787 http://www.ncbi.nlm.nih.gov/pubmed/11023787 PubMed 11359578 http://www.ncbi.nlm.nih.gov/pubmed/11359578 PubMed 12080332 http://www.ncbi.nlm.nih.gov/pubmed/12080332 PubMed 1390767 http://www.ncbi.nlm.nih.gov/pubmed/1390767 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17998207 http://www.ncbi.nlm.nih.gov/pubmed/17998207 PubMed 1869568 http://www.ncbi.nlm.nih.gov/pubmed/1869568 PubMed 20346719 http://www.ncbi.nlm.nih.gov/pubmed/20346719 PubMed 2689446 http://www.ncbi.nlm.nih.gov/pubmed/2689446 PubMed 3280143 http://www.ncbi.nlm.nih.gov/pubmed/3280143 PubMed 3510184 http://www.ncbi.nlm.nih.gov/pubmed/3510184 PubMed 6090423 http://www.ncbi.nlm.nih.gov/pubmed/6090423 PubMed 8176739 http://www.ncbi.nlm.nih.gov/pubmed/8176739 PubMed 8354264 http://www.ncbi.nlm.nih.gov/pubmed/8354264 PubMed 8632450 http://www.ncbi.nlm.nih.gov/pubmed/8632450 PubMed 8820640 http://www.ncbi.nlm.nih.gov/pubmed/8820640 PubMed 9030562 http://www.ncbi.nlm.nih.gov/pubmed/9030562 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9437425 http://www.ncbi.nlm.nih.gov/pubmed/9437425 PubMed 9560203 http://www.ncbi.nlm.nih.gov/pubmed/9560203 PubMed 9636149 http://www.ncbi.nlm.nih.gov/pubmed/9636149 PubMed 9761838 http://www.ncbi.nlm.nih.gov/pubmed/9761838 PubMed 9761905 http://www.ncbi.nlm.nih.gov/pubmed/9761905 RefSeq NP_416396 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416396 RefSeq WP_000763867 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000763867 SMART SM00448 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00448 SMR P0AE67 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AE67 STRING 511145.b1882 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1882&targetmode=cogs STRING COG0784 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0784&targetmode=cogs SUPFAM SSF52172 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52172 SWISS-2DPAGE P0AE67 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AE67 UniProtKB CHEY_ECOLI http://www.uniprot.org/uniprot/CHEY_ECOLI UniProtKB-AC P0AE67 http://www.uniprot.org/uniprot/P0AE67 charge swissprot:CHEY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CHEY_ECOLI eggNOG COG0784 http://eggnogapi.embl.de/nog_data/html/tree/COG0784 eggNOG ENOG4108VYJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108VYJ epestfind swissprot:CHEY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CHEY_ECOLI garnier swissprot:CHEY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CHEY_ECOLI helixturnhelix swissprot:CHEY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CHEY_ECOLI hmoment swissprot:CHEY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CHEY_ECOLI iep swissprot:CHEY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CHEY_ECOLI inforesidue swissprot:CHEY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CHEY_ECOLI octanol swissprot:CHEY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CHEY_ECOLI pepcoil swissprot:CHEY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CHEY_ECOLI pepdigest swissprot:CHEY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CHEY_ECOLI pepinfo swissprot:CHEY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CHEY_ECOLI pepnet swissprot:CHEY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CHEY_ECOLI pepstats swissprot:CHEY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CHEY_ECOLI pepwheel swissprot:CHEY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CHEY_ECOLI pepwindow swissprot:CHEY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CHEY_ECOLI sigcleave swissprot:CHEY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CHEY_ECOLI ## Database ID URL or Descriptions # AltName TREC_ECOLI Alpha,alpha-phosphotrehalase # BIOPHYSICOCHEMICAL PROPERTIES TREC_ECOLI Kinetic parameters KM=6 mM for trehalose-6-phosphate {ECO 0000269|PubMed 8083158}; Vmax=5.5 umol/min/mg enzyme {ECO 0000269|PubMed 8083158}; # BioGrid 4259319 11 # CATALYTIC ACTIVITY Alpha,alpha-trehalose 6-phosphate + H(2)O = D- glucose + D-glucose 6-phosphate. {ECO:0000269|PubMed 8083158}. # CAZy GH13 Glycoside Hydrolase Family 13 # EcoGene EG11402 treC # FUNCTION TREC_ECOLI Hydrolyzes trehalose-6-phosphate to glucose and glucose 6-phosphate. Can also very effectively hydrolyzes p-nitrophenyl- alpha-D-glucopyranoside, but it does not recognize trehalose, sucrose, maltose, isomaltose, or maltodextrins. {ECO 0000269|PubMed 8083158}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008788 alpha,alpha-phosphotrehalase activity; IDA:EcoCyc. # GO_process GO:0005993 trehalose catabolic process; IMP:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009056 catabolic process # Gene3D 2.60.40.1180 -; 1. # Gene3D 3.20.20.80 -; 2. # IntAct P28904 8 # InterPro IPR006047 Glyco_hydro_13_cat_dom # InterPro IPR012769 Trehalose_TreC # InterPro IPR013780 Glyco_hydro_b # InterPro IPR013781 Glyco_hydro_catalytic_dom # InterPro IPR015902 Glyco_hydro_13 # InterPro IPR017853 Glycoside_hydrolase_SF # InterPro IPR022567 DUF3459 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00500 Starch and sucrose metabolism # Organism TREC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10357 PTHR10357; 3 # PATRIC 32124053 VBIEscCol129921_4371 # PIR S56465 S56465 # Pfam PF00128 Alpha-amylase # Pfam PF11941 DUF3459 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Trehalose-6-phosphate hydrolase {ECO:0000303|PubMed 8083158} # RefSeq NP_418660 NC_000913.3 # RefSeq WP_001336303 NZ_LN832404.1 # SIMILARITY Belongs to the glycosyl hydrolase 13 family. {ECO 0000305}. # SMART SM00642 Aamy # SUBCELLULAR LOCATION TREC_ECOLI Cytoplasm {ECO 0000305|PubMed 8083158}. # SUPFAM SSF51445 SSF51445 # TIGRFAMs TIGR02403 trehalose_treC # eggNOG COG0366 LUCA # eggNOG ENOG4105CG3 Bacteria BLAST swissprot:TREC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TREC_ECOLI BioCyc ECOL316407:JW4198-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4198-MONOMER BioCyc EcoCyc:TRE6PHYDRO-MONOMER http://biocyc.org/getid?id=EcoCyc:TRE6PHYDRO-MONOMER BioCyc MetaCyc:TRE6PHYDRO-MONOMER http://biocyc.org/getid?id=MetaCyc:TRE6PHYDRO-MONOMER COG COG0366 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0366 DIP DIP-11024N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11024N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.90.2.577 http://dx.doi.org/10.1073/pnas.90.2.577 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.2.1.93 {ECO:0000269|PubMed:8083158} http://www.genome.jp/dbget-bin/www_bget?EC:3.2.1.93 {ECO:0000269|PubMed:8083158} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L06097 http://www.ebi.ac.uk/ena/data/view/L06097 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U06195 http://www.ebi.ac.uk/ena/data/view/U06195 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 3.2.1.93 {ECO:0000269|PubMed:8083158} http://enzyme.expasy.org/EC/3.2.1.93 {ECO:0000269|PubMed:8083158} EchoBASE EB1374 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1374 EcoGene EG11402 http://www.ecogene.org/geneInfo.php?eg_id=EG11402 EnsemblBacteria AAC77196 http://www.ensemblgenomes.org/id/AAC77196 EnsemblBacteria AAC77196 http://www.ensemblgenomes.org/id/AAC77196 EnsemblBacteria BAE78238 http://www.ensemblgenomes.org/id/BAE78238 EnsemblBacteria BAE78238 http://www.ensemblgenomes.org/id/BAE78238 EnsemblBacteria BAE78238 http://www.ensemblgenomes.org/id/BAE78238 EnsemblBacteria b4239 http://www.ensemblgenomes.org/id/b4239 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008788 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008788 GO_process GO:0005993 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005993 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 2.60.40.1180 http://www.cathdb.info/version/latest/superfamily/2.60.40.1180 Gene3D 3.20.20.80 http://www.cathdb.info/version/latest/superfamily/3.20.20.80 GeneID 948762 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948762 HOGENOM HOG000220641 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220641&db=HOGENOM6 InParanoid P28904 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P28904 IntAct P28904 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P28904* IntEnz 3.2.1.93 {ECO:0000269|PubMed:8083158} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.2.1.93 {ECO:0000269|PubMed:8083158} InterPro IPR006047 http://www.ebi.ac.uk/interpro/entry/IPR006047 InterPro IPR012769 http://www.ebi.ac.uk/interpro/entry/IPR012769 InterPro IPR013780 http://www.ebi.ac.uk/interpro/entry/IPR013780 InterPro IPR013781 http://www.ebi.ac.uk/interpro/entry/IPR013781 InterPro IPR015902 http://www.ebi.ac.uk/interpro/entry/IPR015902 InterPro IPR017853 http://www.ebi.ac.uk/interpro/entry/IPR017853 InterPro IPR022567 http://www.ebi.ac.uk/interpro/entry/IPR022567 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4198 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4198 KEGG_Gene eco:b4239 http://www.genome.jp/dbget-bin/www_bget?eco:b4239 KEGG_Orthology KO:K01226 http://www.genome.jp/dbget-bin/www_bget?KO:K01226 KEGG_Pathway ko00500 http://www.genome.jp/kegg-bin/show_pathway?ko00500 KEGG_Reaction rn:R00837 http://www.genome.jp/dbget-bin/www_bget?rn:R00837 KEGG_Reaction rn:R06113 http://www.genome.jp/dbget-bin/www_bget?rn:R06113 OMA PKRDWYW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PKRDWYW PANTHER PTHR10357 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10357 PSORT swissprot:TREC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TREC_ECOLI PSORT-B swissprot:TREC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TREC_ECOLI PSORT2 swissprot:TREC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TREC_ECOLI Pfam PF00128 http://pfam.xfam.org/family/PF00128 Pfam PF11941 http://pfam.xfam.org/family/PF11941 Phobius swissprot:TREC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TREC_ECOLI PhylomeDB P28904 http://phylomedb.org/?seqid=P28904 ProteinModelPortal P28904 http://www.proteinmodelportal.org/query/uniprot/P28904 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8083158 http://www.ncbi.nlm.nih.gov/pubmed/8083158 PubMed 8421692 http://www.ncbi.nlm.nih.gov/pubmed/8421692 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418660 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418660 RefSeq WP_001336303 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001336303 SMART SM00642 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00642 SMR P28904 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P28904 STRING 511145.b4239 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4239&targetmode=cogs STRING COG0366 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0366&targetmode=cogs SUPFAM SSF51445 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51445 TIGRFAMs TIGR02403 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02403 UniProtKB TREC_ECOLI http://www.uniprot.org/uniprot/TREC_ECOLI UniProtKB-AC P28904 http://www.uniprot.org/uniprot/P28904 charge swissprot:TREC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TREC_ECOLI eggNOG COG0366 http://eggnogapi.embl.de/nog_data/html/tree/COG0366 eggNOG ENOG4105CG3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CG3 epestfind swissprot:TREC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TREC_ECOLI garnier swissprot:TREC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TREC_ECOLI helixturnhelix swissprot:TREC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TREC_ECOLI hmoment swissprot:TREC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TREC_ECOLI iep swissprot:TREC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TREC_ECOLI inforesidue swissprot:TREC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TREC_ECOLI octanol swissprot:TREC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TREC_ECOLI pepcoil swissprot:TREC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TREC_ECOLI pepdigest swissprot:TREC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TREC_ECOLI pepinfo swissprot:TREC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TREC_ECOLI pepnet swissprot:TREC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TREC_ECOLI pepstats swissprot:TREC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TREC_ECOLI pepwheel swissprot:TREC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TREC_ECOLI pepwindow swissprot:TREC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TREC_ECOLI sigcleave swissprot:TREC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TREC_ECOLI ## Database ID URL or Descriptions # BioGrid 4259581 11 # CDD cd07377 WHTH_GntR # EcoGene EG12913 frlR # FUNCTION FRLR_ECOLI May regulate the transcription of the frlABCD operon. {ECO 0000269|PubMed 12147680}. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; ISS:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # Gene3D 3.40.1410.10 -; 1. # IntAct P45544 5 # InterPro IPR000524 Tscrpt_reg_HTH_GntR # InterPro IPR011663 UTRA # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR028978 Chorismate_lyase_/UTRA_dom # KEGG_Brite ko03000 Transcription factors # Organism FRLR_ECOLI Escherichia coli (strain K12) # PATHWAY FRLR_ECOLI Carbohydrate metabolism; fructoselysine degradation [regulation]. # PATRIC 32122182 VBIEscCol129921_3468 # PIR B65132 B65132 # PRINTS PR00035 HTHGNTR # PROSITE PS50949 HTH_GNTR # Pfam PF00392 GntR # Pfam PF07702 UTRA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FRLR_ECOLI HTH-type transcriptional regulator FrlR # RefSeq NP_417834 NC_000913.3 # RefSeq WP_001276847 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA58172.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Contains 1 HTH gntR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00307}. # SMART SM00345 HTH_GNTR # SMART SM00866 UTRA # SUPFAM SSF46785 SSF46785 # SUPFAM SSF64288 SSF64288 # eggNOG COG2188 LUCA # eggNOG ENOG4105FDP Bacteria BLAST swissprot:FRLR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FRLR_ECOLI BioCyc ECOL316407:JW5698-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5698-MONOMER BioCyc EcoCyc:G7727-MONOMER http://biocyc.org/getid?id=EcoCyc:G7727-MONOMER COG COG2188 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2188 DIP DIP-12327N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12327N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M200863200 http://dx.doi.org/10.1074/jbc.M200863200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2749 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2749 EcoGene EG12913 http://www.ecogene.org/geneInfo.php?eg_id=EG12913 EnsemblBacteria AAC76400 http://www.ensemblgenomes.org/id/AAC76400 EnsemblBacteria AAC76400 http://www.ensemblgenomes.org/id/AAC76400 EnsemblBacteria BAE77916 http://www.ensemblgenomes.org/id/BAE77916 EnsemblBacteria BAE77916 http://www.ensemblgenomes.org/id/BAE77916 EnsemblBacteria BAE77916 http://www.ensemblgenomes.org/id/BAE77916 EnsemblBacteria b3375 http://www.ensemblgenomes.org/id/b3375 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 3.40.1410.10 http://www.cathdb.info/version/latest/superfamily/3.40.1410.10 GeneID 947885 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947885 HOGENOM HOG000228717 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000228717&db=HOGENOM6 InParanoid P45544 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45544 IntAct P45544 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45544* InterPro IPR000524 http://www.ebi.ac.uk/interpro/entry/IPR000524 InterPro IPR011663 http://www.ebi.ac.uk/interpro/entry/IPR011663 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR028978 http://www.ebi.ac.uk/interpro/entry/IPR028978 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW5698 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5698 KEGG_Gene eco:b3375 http://www.genome.jp/dbget-bin/www_bget?eco:b3375 KEGG_Orthology KO:K10711 http://www.genome.jp/dbget-bin/www_bget?KO:K10711 OMA EGNPVEW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EGNPVEW PRINTS PR00035 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00035 PROSITE PS50949 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50949 PSORT swissprot:FRLR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FRLR_ECOLI PSORT-B swissprot:FRLR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FRLR_ECOLI PSORT2 swissprot:FRLR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FRLR_ECOLI Pfam PF00392 http://pfam.xfam.org/family/PF00392 Pfam PF07702 http://pfam.xfam.org/family/PF07702 Phobius swissprot:FRLR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FRLR_ECOLI PhylomeDB P45544 http://phylomedb.org/?seqid=P45544 ProteinModelPortal P45544 http://www.proteinmodelportal.org/query/uniprot/P45544 PubMed 12147680 http://www.ncbi.nlm.nih.gov/pubmed/12147680 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417834 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417834 RefSeq WP_001276847 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001276847 SMART SM00345 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00345 SMART SM00866 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00866 SMR P45544 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45544 STRING 511145.b3375 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3375&targetmode=cogs STRING COG2188 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2188&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SUPFAM SSF64288 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF64288 UniProtKB FRLR_ECOLI http://www.uniprot.org/uniprot/FRLR_ECOLI UniProtKB-AC P45544 http://www.uniprot.org/uniprot/P45544 charge swissprot:FRLR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FRLR_ECOLI eggNOG COG2188 http://eggnogapi.embl.de/nog_data/html/tree/COG2188 eggNOG ENOG4105FDP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FDP epestfind swissprot:FRLR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FRLR_ECOLI garnier swissprot:FRLR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FRLR_ECOLI helixturnhelix swissprot:FRLR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FRLR_ECOLI hmoment swissprot:FRLR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FRLR_ECOLI iep swissprot:FRLR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FRLR_ECOLI inforesidue swissprot:FRLR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FRLR_ECOLI octanol swissprot:FRLR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FRLR_ECOLI pepcoil swissprot:FRLR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FRLR_ECOLI pepdigest swissprot:FRLR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FRLR_ECOLI pepinfo swissprot:FRLR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FRLR_ECOLI pepnet swissprot:FRLR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FRLR_ECOLI pepstats swissprot:FRLR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FRLR_ECOLI pepwheel swissprot:FRLR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FRLR_ECOLI pepwindow swissprot:FRLR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FRLR_ECOLI sigcleave swissprot:FRLR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FRLR_ECOLI ## Database ID URL or Descriptions # InterPro IPR014571 UCP032620 # InterPro IPR019302 TIR-like_dom # Organism YUAY_ECOLI Escherichia coli (strain K12) # PIRSF PIRSF032620 UCP032620 # Pfam PF10137 TIR-like # RecName YUAY_ECOLI Uncharacterized protein YuaY # RefSeq NP_061418 NC_002483.1 # RefSeq WP_000963206 NZ_CP014273.1 # RefSeq YP_002527517 NC_011964.1 BLAST swissprot:YUAY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YUAY_ECOLI DOI 10.1128/IAI.71.6.3285-3293.2003 http://dx.doi.org/10.1128/IAI.71.6.3285-3293.2003 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL AY205565 http://www.ebi.ac.uk/ena/data/view/AY205565 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1263545 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263545 GeneID 7324542 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7324542 InterPro IPR014571 http://www.ebi.ac.uk/interpro/entry/IPR014571 InterPro IPR019302 http://www.ebi.ac.uk/interpro/entry/IPR019302 OMA HEQANRG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HEQANRG PSORT swissprot:YUAY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YUAY_ECOLI PSORT-B swissprot:YUAY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YUAY_ECOLI PSORT2 swissprot:YUAY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YUAY_ECOLI Pfam PF10137 http://pfam.xfam.org/family/PF10137 Phobius swissprot:YUAY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YUAY_ECOLI ProteinModelPortal Q9JMR6 http://www.proteinmodelportal.org/query/uniprot/Q9JMR6 PubMed 12761110 http://www.ncbi.nlm.nih.gov/pubmed/12761110 RefSeq NP_061418 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061418 RefSeq WP_000963206 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000963206 RefSeq YP_002527517 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_002527517 UniProtKB YUAY_ECOLI http://www.uniprot.org/uniprot/YUAY_ECOLI UniProtKB-AC Q9JMR6 http://www.uniprot.org/uniprot/Q9JMR6 charge swissprot:YUAY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YUAY_ECOLI epestfind swissprot:YUAY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YUAY_ECOLI garnier swissprot:YUAY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YUAY_ECOLI helixturnhelix swissprot:YUAY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YUAY_ECOLI hmoment swissprot:YUAY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YUAY_ECOLI iep swissprot:YUAY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YUAY_ECOLI inforesidue swissprot:YUAY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YUAY_ECOLI octanol swissprot:YUAY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YUAY_ECOLI pepcoil swissprot:YUAY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YUAY_ECOLI pepdigest swissprot:YUAY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YUAY_ECOLI pepinfo swissprot:YUAY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YUAY_ECOLI pepnet swissprot:YUAY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YUAY_ECOLI pepstats swissprot:YUAY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YUAY_ECOLI pepwheel swissprot:YUAY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YUAY_ECOLI pepwindow swissprot:YUAY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YUAY_ECOLI sigcleave swissprot:YUAY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YUAY_ECOLI ## Database ID URL or Descriptions # BioGrid 4262023 9 # CATALYTIC ACTIVITY Acetyl-CoA + (S)-1-aminoethylphosphonate = CoA + N-acetyl-(S)-1-aminoethylphosphonate. {ECO:0000269|PubMed 23056305}. # CATALYTIC ACTIVITY Acetyl-CoA + aminomethylphosphonate = CoA + N- acetamidomethylphosphonate. {ECO:0000269|PubMed 23056305}. # COFACTOR PHNO_ECOLI Name=a divalent metal cation; Xref=ChEBI CHEBI 60240; Evidence={ECO 0000250|UniProtKB Q8ZKE6}; # DISRUPTION PHENOTYPE Cells lacking this gene have lost the ability to utilize aminomethylphosphonate or (S)-1- aminoethylphosphonate as the sole source of phosphate for growth, but are still able to utilize the other aminoalkylphosphonates 2- aminoethyl- and 3-aminopropylphosphonate, and alkylphosphonates. They are also much more susceptible to the bacteriocidal effect of (S)-1-aminoethylphosphonate, even with phosphate or D-alanine present. {ECO:0000269|PubMed 23056305}. # EcoGene EG10724 phnO # FUNCTION PHNO_ECOLI Aminoalkylphosphonate N-acetyltransferase which is able to acetylate a range of aminoalkylphosphonic acids, including aminomethylphosphonate, (S)-1-aminoethylphosphonate and 2- aminoethyl- and 3-aminopropylphosphonate, using acetyl-CoA as acetyl donor. Is required for the utilization of aminomethylphosphonate and (S)-1-aminoethylphosphonate as a phosphate source via the C-P lyase pathway. Is also essential for the detoxification of (S)-1-aminoethylphosphonate, a structural analog of D-alanine that has bacteriocidal properties due to inhibition of cell wall synthesis. {ECO 0000269|PubMed 23056305}. # GO_component GO:0031248 protein acetyltransferase complex; IBA:GO_Central. # GO_function GO:0004596 peptide alpha-N-acetyltransferase activity; IBA:GO_Central. # GO_function GO:0008080 N-acetyltransferase activity; IDA:EcoCyc. # GO_process GO:0006474 N-terminal protein amino acid acetylation; IBA:GO_Central. # GO_process GO:0033051 aminophosphonate metabolic process; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0008150 biological_process # Gene3D 3.40.630.30 -; 1. # InterPro IPR000182 GNAT_dom # InterPro IPR016181 Acyl_CoA_acyltransferase # KEGG_Brite ko01000 Enzymes # MISCELLANEOUS PHNO_ECOLI The sequence shown is that of strains K12 and B. # Organism PHNO_ECOLI Escherichia coli (strain K12) # PATRIC 32123745 VBIEscCol129921_4221 # PIR G35719 G35719 # PROSITE PS51186 GNAT # Pfam PF00583 Acetyltransf_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Aminoalkylphosphonate N-acetyltransferase {ECO:0000303|PubMed 23056305} # RefSeq NP_418517 NC_000913.3 # RefSeq WP_001110490 NZ_LN832404.1 # SIMILARITY Contains 1 N-acetyltransferase domain. {ECO:0000255|PROSITE-ProRule PRU00532}. # SUBUNIT Homodimer. {ECO:0000250|UniProtKB Q8ZKE6}. # SUPFAM SSF55729 SSF55729 # eggNOG ENOG410849A Bacteria # eggNOG ENOG410ZXJ8 LUCA BLAST swissprot:PHNO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PHNO_ECOLI BioCyc ECOL316407:JW4054-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4054-MONOMER BioCyc EcoCyc:EG10724-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10724-MONOMER BioCyc MetaCyc:EG10724-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10724-MONOMER COG COG0454 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0454 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pone.0046416 http://dx.doi.org/10.1371/journal.pone.0046416 EC_number EC:2.3.1.- {ECO:0000269|PubMed:23056305} http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.- {ECO:0000269|PubMed:23056305} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D90227 http://www.ebi.ac.uk/ena/data/view/D90227 EMBL J05260 http://www.ebi.ac.uk/ena/data/view/J05260 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 2.3.1.- {ECO:0000269|PubMed:23056305} http://enzyme.expasy.org/EC/2.3.1.- {ECO:0000269|PubMed:23056305} EchoBASE EB0718 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0718 EcoGene EG10724 http://www.ecogene.org/geneInfo.php?eg_id=EG10724 EnsemblBacteria AAC77054 http://www.ensemblgenomes.org/id/AAC77054 EnsemblBacteria AAC77054 http://www.ensemblgenomes.org/id/AAC77054 EnsemblBacteria BAE78096 http://www.ensemblgenomes.org/id/BAE78096 EnsemblBacteria BAE78096 http://www.ensemblgenomes.org/id/BAE78096 EnsemblBacteria BAE78096 http://www.ensemblgenomes.org/id/BAE78096 EnsemblBacteria b4093 http://www.ensemblgenomes.org/id/b4093 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0031248 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031248 GO_function GO:0004596 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004596 GO_function GO:0008080 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008080 GO_process GO:0006474 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006474 GO_process GO:0033051 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033051 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.630.30 http://www.cathdb.info/version/latest/superfamily/3.40.630.30 GeneID 948599 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948599 HOGENOM HOG000078524 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000078524&db=HOGENOM6 InParanoid P16691 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P16691 IntAct P16691 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P16691* IntEnz 2.3.1.- {ECO:0000269|PubMed:23056305} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.- {ECO:0000269|PubMed:23056305} InterPro IPR000182 http://www.ebi.ac.uk/interpro/entry/IPR000182 InterPro IPR016181 http://www.ebi.ac.uk/interpro/entry/IPR016181 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4054 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4054 KEGG_Gene eco:b4093 http://www.genome.jp/dbget-bin/www_bget?eco:b4093 KEGG_Orthology KO:K09994 http://www.genome.jp/dbget-bin/www_bget?KO:K09994 OMA GMIGLHM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GMIGLHM PROSITE PS51186 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51186 PSORT swissprot:PHNO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PHNO_ECOLI PSORT-B swissprot:PHNO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PHNO_ECOLI PSORT2 swissprot:PHNO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PHNO_ECOLI Pfam PF00583 http://pfam.xfam.org/family/PF00583 Phobius swissprot:PHNO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PHNO_ECOLI PhylomeDB P16691 http://phylomedb.org/?seqid=P16691 ProteinModelPortal P16691 http://www.proteinmodelportal.org/query/uniprot/P16691 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1840580 http://www.ncbi.nlm.nih.gov/pubmed/1840580 PubMed 2155230 http://www.ncbi.nlm.nih.gov/pubmed/2155230 PubMed 23056305 http://www.ncbi.nlm.nih.gov/pubmed/23056305 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418517 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418517 RefSeq WP_001110490 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001110490 SMR P16691 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P16691 STRING 511145.b4093 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4093&targetmode=cogs STRING COG0454 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0454&targetmode=cogs SUPFAM SSF55729 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55729 UniProtKB PHNO_ECOLI http://www.uniprot.org/uniprot/PHNO_ECOLI UniProtKB-AC P16691 http://www.uniprot.org/uniprot/P16691 charge swissprot:PHNO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PHNO_ECOLI eggNOG ENOG410849A http://eggnogapi.embl.de/nog_data/html/tree/ENOG410849A eggNOG ENOG410ZXJ8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZXJ8 epestfind swissprot:PHNO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PHNO_ECOLI garnier swissprot:PHNO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PHNO_ECOLI helixturnhelix swissprot:PHNO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PHNO_ECOLI hmoment swissprot:PHNO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PHNO_ECOLI iep swissprot:PHNO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PHNO_ECOLI inforesidue swissprot:PHNO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PHNO_ECOLI octanol swissprot:PHNO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PHNO_ECOLI pepcoil swissprot:PHNO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PHNO_ECOLI pepdigest swissprot:PHNO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PHNO_ECOLI pepinfo swissprot:PHNO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PHNO_ECOLI pepnet swissprot:PHNO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PHNO_ECOLI pepstats swissprot:PHNO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PHNO_ECOLI pepwheel swissprot:PHNO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PHNO_ECOLI pepwindow swissprot:PHNO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PHNO_ECOLI sigcleave swissprot:PHNO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PHNO_ECOLI ## Database ID URL or Descriptions # EcoGene EG40006 insF1 # FUNCTION INSF1_ECOLI Involved in the transposition of the insertion sequence IS3. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006310 DNA recombination; IEA:UniProtKB-KW. # GO_process GO:0015074 DNA integration; IEA:InterPro. # GO_process GO:0032196 transposition; IDA:EcoCyc. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 3.30.420.10 -; 1. # InterPro IPR001584 Integrase_cat-core # InterPro IPR012337 RNaseH-like_dom # InterPro IPR025948 HTH-like_dom # Organism INSF1_ECOLI Escherichia coli (strain K12) # PIR C64756 TQECI3 # PROSITE PS50994 INTEGRASE # Pfam PF00665 rve # Pfam PF13276 HTH_21 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSF1_ECOLI Transposase InsF for insertion sequence IS3A # RefSeq NP_061381 NC_002483.1 # RefSeq NP_414833 NC_000913.3 # RefSeq NP_414906 NC_000913.3 # RefSeq NP_415073 NC_000913.3 # RefSeq NP_415545 NC_000913.3 # RefSeq NP_416593 NC_000913.3 # RefSeq WP_000878218 NZ_LN832404.1 # SIMILARITY Belongs to the transposase IS3/IS150/IS904 family. {ECO 0000305}. # SIMILARITY Contains 1 integrase catalytic domain. {ECO:0000255|PROSITE-ProRule PRU00457}. # SUPFAM SSF53098 SSF53098 # eggNOG COG2801 LUCA BLAST swissprot:INSF1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSF1_ECOLI BioCyc EcoCyc:G7126-MONOMER http://biocyc.org/getid?id=EcoCyc:G7126-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/13.6.2127 http://dx.doi.org/10.1093/nar/13.6.2127 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EMBL X02311 http://www.ebi.ac.uk/ena/data/view/X02311 EchoBASE EB4710 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4710 EcoGene EG40006 http://www.ecogene.org/geneInfo.php?eg_id=EG40006 EnsemblBacteria AAC73402 http://www.ensemblgenomes.org/id/AAC73402 EnsemblBacteria AAC73402 http://www.ensemblgenomes.org/id/AAC73402 EnsemblBacteria BAE76084 http://www.ensemblgenomes.org/id/BAE76084 EnsemblBacteria BAE76084 http://www.ensemblgenomes.org/id/BAE76084 EnsemblBacteria BAE76084 http://www.ensemblgenomes.org/id/BAE76084 EnsemblBacteria b0299 http://www.ensemblgenomes.org/id/b0299 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0015074 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015074 GO_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 3.30.420.10 http://www.cathdb.info/version/latest/superfamily/3.30.420.10 GeneID 1263587 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263587 GeneID 944948 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944948 GeneID 945036 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945036 GeneID 945587 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945587 GeneID 946629 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946629 GeneID 947988 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947988 InParanoid P0CF79 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CF79 InterPro IPR001584 http://www.ebi.ac.uk/interpro/entry/IPR001584 InterPro IPR012337 http://www.ebi.ac.uk/interpro/entry/IPR012337 InterPro IPR025948 http://www.ebi.ac.uk/interpro/entry/IPR025948 KEGG_Gene ecj:JW0293 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0293 KEGG_Gene eco:b0299 http://www.genome.jp/dbget-bin/www_bget?eco:b0299 KEGG_Gene eco:b0372 http://www.genome.jp/dbget-bin/www_bget?eco:b0372 KEGG_Gene eco:b0541 http://www.genome.jp/dbget-bin/www_bget?eco:b0541 KEGG_Gene eco:b1026 http://www.genome.jp/dbget-bin/www_bget?eco:b1026 KEGG_Gene eco:b2089 http://www.genome.jp/dbget-bin/www_bget?eco:b2089 PROSITE PS50994 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50994 PSORT swissprot:INSF1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSF1_ECOLI PSORT-B swissprot:INSF1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSF1_ECOLI PSORT2 swissprot:INSF1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSF1_ECOLI Pfam PF00665 http://pfam.xfam.org/family/PF00665 Pfam PF13276 http://pfam.xfam.org/family/PF13276 Phobius swissprot:INSF1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSF1_ECOLI PhylomeDB P0CF79 http://phylomedb.org/?seqid=P0CF79 ProteinModelPortal P0CF79 http://www.proteinmodelportal.org/query/uniprot/P0CF79 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2987844 http://www.ncbi.nlm.nih.gov/pubmed/2987844 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_061381 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061381 RefSeq NP_414833 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414833 RefSeq NP_414906 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414906 RefSeq NP_415073 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415073 RefSeq NP_415545 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415545 RefSeq NP_416593 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416593 RefSeq WP_000878218 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000878218 SMR P0CF79 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0CF79 STRING 511145.b2089 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2089&targetmode=cogs SUPFAM SSF53098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098 UniProtKB INSF1_ECOLI http://www.uniprot.org/uniprot/INSF1_ECOLI UniProtKB-AC P0CF79 http://www.uniprot.org/uniprot/P0CF79 charge swissprot:INSF1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSF1_ECOLI eggNOG COG2801 http://eggnogapi.embl.de/nog_data/html/tree/COG2801 epestfind swissprot:INSF1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSF1_ECOLI garnier swissprot:INSF1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSF1_ECOLI helixturnhelix swissprot:INSF1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSF1_ECOLI hmoment swissprot:INSF1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSF1_ECOLI iep swissprot:INSF1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSF1_ECOLI inforesidue swissprot:INSF1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSF1_ECOLI octanol swissprot:INSF1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSF1_ECOLI pepcoil swissprot:INSF1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSF1_ECOLI pepdigest swissprot:INSF1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSF1_ECOLI pepinfo swissprot:INSF1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSF1_ECOLI pepnet swissprot:INSF1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSF1_ECOLI pepstats swissprot:INSF1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSF1_ECOLI pepwheel swissprot:INSF1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSF1_ECOLI pepwindow swissprot:INSF1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSF1_ECOLI sigcleave swissprot:INSF1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSF1_ECOLI ## Database ID URL or Descriptions # AltName UPPS_ECOLI Ditrans,polycis-undecaprenylcistransferase # AltName UPPS_ECOLI Undecaprenyl diphosphate synthase # AltName UPPS_ECOLI Undecaprenyl pyrophosphate synthase # BIOPHYSICOCHEMICAL PROPERTIES UPPS_ECOLI Kinetic parameters KM=0.4 uM for FPP (at pH 7.5 and at 25 degrees Celsius) {ECO 0000269|PubMed 12756244}; KM=4.1 uM for IPP (at pH 7.5 and at 25 degrees Celsius) {ECO 0000269|PubMed 12756244}; # BRENDA 2.5.1.31 2026 # BioGrid 4260767 393 # CATALYTIC ACTIVITY UPPS_ECOLI (2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate = 8 diphosphate + di-trans,octa-cis-undecaprenyl diphosphate. # CDD cd00475 Cis_IPPS # COFACTOR UPPS_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 12756244, ECO 0000269|PubMed 15044730}; Note=Binds 2 magnesium ions per subunit. {ECO 0000269|PubMed 12756244, ECO 0000269|PubMed 15044730}; # ENZYME REGULATION Inhibited by bisphosphonates. {ECO:0000269|PubMed 17535895}. # EcoGene EG13329 ispU # FUNCTION UPPS_ECOLI Generates ditrans,octacis-undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP) and farnesyl diphosphate (FPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. {ECO 0000269|PubMed 12756244}. # GO_component GO:0005737 cytoplasm; IDA:EcoCyc. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0002094 polyprenyltransferase activity; IBA:GO_Central. # GO_function GO:0008834 di-trans,poly-cis-decaprenylcistransferase activity; IDA:EcoCyc. # GO_process GO:0007049 cell cycle; IEA:UniProtKB-KW. # GO_process GO:0008360 regulation of cell shape; IEA:UniProtKB-KW. # GO_process GO:0009252 peptidoglycan biosynthetic process; IMP:EcoCyc. # GO_process GO:0016094 polyprenol biosynthetic process; IDA:EcoCyc. # GO_process GO:0043164 Gram-negative-bacterium-type cell wall biogenesis; IMP:EcoCyc. # GO_process GO:0051301 cell division; IEA:UniProtKB-KW. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0007049 cell cycle # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051301 cell division # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 3.40.1180.10 -; 1. # HAMAP MF_01139 ISPT # IntAct P60472 4 # InterPro IPR001441 UPP_synth-like # InterPro IPR018520 UPP_synth-like_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01006 Prenyltransferases # KEGG_Pathway ko00900 Terpenoid backbone biosynthesis # Organism UPPS_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10291 PTHR10291 # PATRIC 32115457 VBIEscCol129921_0180 # PDB 1JP3 X-ray; 1.80 A; A/B=1-253 # PDB 1UEH X-ray; 1.73 A; A/B=1-253 # PDB 1V7U X-ray; 2.35 A; A/B=1-253 # PDB 1X06 X-ray; 1.90 A; A=1-253 # PDB 1X07 X-ray; 2.20 A; A=1-253 # PDB 1X08 X-ray; 1.90 A; A=1-253 # PDB 1X09 X-ray; 1.87 A; A=1-253 # PDB 2E98 X-ray; 1.90 A; A/B=1-253 # PDB 2E99 X-ray; 2.00 A; A/B=1-253 # PDB 2E9A X-ray; 2.10 A; A/B=1-253 # PDB 2E9C X-ray; 2.05 A; A/B=1-253 # PDB 2E9D X-ray; 2.50 A; A/B=1-253 # PDB 3QAS X-ray; 1.70 A; A/B=1-253 # PDB 3SGV X-ray; 1.61 A; A/B=1-253 # PDB 3SGX X-ray; 2.45 A; A/B=1-253 # PDB 3SH0 X-ray; 1.84 A; A/B=1-253 # PDB 3TH8 X-ray; 2.11 A; A/B=1-253 # PDB 3WYJ X-ray; 2.10 A; A/B=1-253 # PDB 4H2J X-ray; 1.81 A; A/B=1-253 # PDB 4H2M X-ray; 1.78 A; A/B=1-253 # PDB 4H2O X-ray; 2.14 A; A/B=1-253 # PDB 4H38 X-ray; 1.95 A; A/B=1-253 # PDB 4H3A X-ray; 1.98 A; A/B=1-253 # PDB 4H3C X-ray; 1.93 A; A/B=1-253 # PDB 5CQB X-ray; 2.20 A; A/B=2-253 # PDB 5CQJ X-ray; 2.15 A; A/B=1-253 # PIR F64741 F64741 # PROSITE PS01066 UPP_SYNTHASE # Pfam PF01255 Prenyltransf # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UPPS_ECOLI Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) # RefSeq NP_414716 NC_000913.3 # SEQUENCE CAUTION Sequence=AAB08603.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the UPP synthase family. {ECO 0000305}. # SUBUNIT UPPS_ECOLI Homodimer. {ECO 0000269|PubMed 11581264, ECO 0000269|PubMed 12756244, ECO 0000269|PubMed 15044730, ECO 0000269|PubMed 15788389, ECO 0000269|PubMed 17535895, ECO 0000269|PubMed 21294851}. # SUPFAM SSF64005 SSF64005 # TIGRFAMs TIGR00055 uppS # eggNOG COG0020 LUCA # eggNOG ENOG4105CR3 Bacteria BLAST swissprot:UPPS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UPPS_ECOLI BioCyc ECOL316407:JW0169-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0169-MONOMER BioCyc EcoCyc:UPPSYN-MONOMER http://biocyc.org/getid?id=EcoCyc:UPPSYN-MONOMER BioCyc MetaCyc:UPPSYN-MONOMER http://biocyc.org/getid?id=MetaCyc:UPPSYN-MONOMER COG COG0020 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0020 DIP DIP-48251N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48251N DOI 10.1016/j.bbrc.2010.09.001 http://dx.doi.org/10.1016/j.bbrc.2010.09.001 DOI 10.1021/bi001226h http://dx.doi.org/10.1021/bi001226h DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0702254104 http://dx.doi.org/10.1073/pnas.0702254104 DOI 10.1074/jbc.M106747200 http://dx.doi.org/10.1074/jbc.M106747200 DOI 10.1074/jbc.M110014200 http://dx.doi.org/10.1074/jbc.M110014200 DOI 10.1074/jbc.M302687200 http://dx.doi.org/10.1074/jbc.M302687200 DOI 10.1074/jbc.M502121200 http://dx.doi.org/10.1074/jbc.M502121200 DOI 10.1110/ps.03519904 http://dx.doi.org/10.1110/ps.03519904 DOI 10.1111/j.1747-0285.2011.01101.x http://dx.doi.org/10.1111/j.1747-0285.2011.01101.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DisProt DP00516 http://www.disprot.org/protein.php?id=DP00516 EC_number EC:2.5.1.31 http://www.genome.jp/dbget-bin/www_bget?EC:2.5.1.31 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 ENZYME 2.5.1.31 http://enzyme.expasy.org/EC/2.5.1.31 EchoBASE EB3113 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3113 EcoGene EG13329 http://www.ecogene.org/geneInfo.php?eg_id=EG13329 EnsemblBacteria AAC73285 http://www.ensemblgenomes.org/id/AAC73285 EnsemblBacteria AAC73285 http://www.ensemblgenomes.org/id/AAC73285 EnsemblBacteria BAA77849 http://www.ensemblgenomes.org/id/BAA77849 EnsemblBacteria BAA77849 http://www.ensemblgenomes.org/id/BAA77849 EnsemblBacteria BAA77849 http://www.ensemblgenomes.org/id/BAA77849 EnsemblBacteria b0174 http://www.ensemblgenomes.org/id/b0174 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0002094 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002094 GO_function GO:0008834 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008834 GO_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0009252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009252 GO_process GO:0016094 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016094 GO_process GO:0043164 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043164 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016765 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 3.40.1180.10 http://www.cathdb.info/version/latest/superfamily/3.40.1180.10 GeneID 944874 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944874 HAMAP MF_01139 http://hamap.expasy.org/unirule/MF_01139 HOGENOM HOG000006054 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006054&db=HOGENOM6 InParanoid P60472 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P60472 IntAct P60472 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P60472* IntEnz 2.5.1.31 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.5.1.31 InterPro IPR001441 http://www.ebi.ac.uk/interpro/entry/IPR001441 InterPro IPR018520 http://www.ebi.ac.uk/interpro/entry/IPR018520 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01006 http://www.genome.jp/dbget-bin/www_bget?ko01006 KEGG_Gene ecj:JW0169 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0169 KEGG_Gene eco:b0174 http://www.genome.jp/dbget-bin/www_bget?eco:b0174 KEGG_Orthology KO:K00806 http://www.genome.jp/dbget-bin/www_bget?KO:K00806 KEGG_Pathway ko00900 http://www.genome.jp/kegg-bin/show_pathway?ko00900 KEGG_Reaction rn:R06447 http://www.genome.jp/dbget-bin/www_bget?rn:R06447 OMA WAKLKNK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WAKLKNK PANTHER PTHR10291 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10291 PDB 1JP3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1JP3 PDB 1UEH http://www.ebi.ac.uk/pdbe-srv/view/entry/1UEH PDB 1V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/1V7U PDB 1X06 http://www.ebi.ac.uk/pdbe-srv/view/entry/1X06 PDB 1X07 http://www.ebi.ac.uk/pdbe-srv/view/entry/1X07 PDB 1X08 http://www.ebi.ac.uk/pdbe-srv/view/entry/1X08 PDB 1X09 http://www.ebi.ac.uk/pdbe-srv/view/entry/1X09 PDB 2E98 http://www.ebi.ac.uk/pdbe-srv/view/entry/2E98 PDB 2E99 http://www.ebi.ac.uk/pdbe-srv/view/entry/2E99 PDB 2E9A http://www.ebi.ac.uk/pdbe-srv/view/entry/2E9A PDB 2E9C http://www.ebi.ac.uk/pdbe-srv/view/entry/2E9C PDB 2E9D http://www.ebi.ac.uk/pdbe-srv/view/entry/2E9D PDB 3QAS http://www.ebi.ac.uk/pdbe-srv/view/entry/3QAS PDB 3SGV http://www.ebi.ac.uk/pdbe-srv/view/entry/3SGV PDB 3SGX http://www.ebi.ac.uk/pdbe-srv/view/entry/3SGX PDB 3SH0 http://www.ebi.ac.uk/pdbe-srv/view/entry/3SH0 PDB 3TH8 http://www.ebi.ac.uk/pdbe-srv/view/entry/3TH8 PDB 3WYJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3WYJ PDB 4H2J http://www.ebi.ac.uk/pdbe-srv/view/entry/4H2J PDB 4H2M http://www.ebi.ac.uk/pdbe-srv/view/entry/4H2M PDB 4H2O http://www.ebi.ac.uk/pdbe-srv/view/entry/4H2O PDB 4H38 http://www.ebi.ac.uk/pdbe-srv/view/entry/4H38 PDB 4H3A http://www.ebi.ac.uk/pdbe-srv/view/entry/4H3A PDB 4H3C http://www.ebi.ac.uk/pdbe-srv/view/entry/4H3C PDB 5CQB http://www.ebi.ac.uk/pdbe-srv/view/entry/5CQB PDB 5CQJ http://www.ebi.ac.uk/pdbe-srv/view/entry/5CQJ PDBsum 1JP3 http://www.ebi.ac.uk/pdbsum/1JP3 PDBsum 1UEH http://www.ebi.ac.uk/pdbsum/1UEH PDBsum 1V7U http://www.ebi.ac.uk/pdbsum/1V7U PDBsum 1X06 http://www.ebi.ac.uk/pdbsum/1X06 PDBsum 1X07 http://www.ebi.ac.uk/pdbsum/1X07 PDBsum 1X08 http://www.ebi.ac.uk/pdbsum/1X08 PDBsum 1X09 http://www.ebi.ac.uk/pdbsum/1X09 PDBsum 2E98 http://www.ebi.ac.uk/pdbsum/2E98 PDBsum 2E99 http://www.ebi.ac.uk/pdbsum/2E99 PDBsum 2E9A http://www.ebi.ac.uk/pdbsum/2E9A PDBsum 2E9C http://www.ebi.ac.uk/pdbsum/2E9C PDBsum 2E9D http://www.ebi.ac.uk/pdbsum/2E9D PDBsum 3QAS http://www.ebi.ac.uk/pdbsum/3QAS PDBsum 3SGV http://www.ebi.ac.uk/pdbsum/3SGV PDBsum 3SGX http://www.ebi.ac.uk/pdbsum/3SGX PDBsum 3SH0 http://www.ebi.ac.uk/pdbsum/3SH0 PDBsum 3TH8 http://www.ebi.ac.uk/pdbsum/3TH8 PDBsum 3WYJ http://www.ebi.ac.uk/pdbsum/3WYJ PDBsum 4H2J http://www.ebi.ac.uk/pdbsum/4H2J PDBsum 4H2M http://www.ebi.ac.uk/pdbsum/4H2M PDBsum 4H2O http://www.ebi.ac.uk/pdbsum/4H2O PDBsum 4H38 http://www.ebi.ac.uk/pdbsum/4H38 PDBsum 4H3A http://www.ebi.ac.uk/pdbsum/4H3A PDBsum 4H3C http://www.ebi.ac.uk/pdbsum/4H3C PDBsum 5CQB http://www.ebi.ac.uk/pdbsum/5CQB PDBsum 5CQJ http://www.ebi.ac.uk/pdbsum/5CQJ PROSITE PS01066 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01066 PSORT swissprot:UPPS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UPPS_ECOLI PSORT-B swissprot:UPPS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UPPS_ECOLI PSORT2 swissprot:UPPS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UPPS_ECOLI Pfam PF01255 http://pfam.xfam.org/family/PF01255 Phobius swissprot:UPPS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UPPS_ECOLI PhylomeDB P60472 http://phylomedb.org/?seqid=P60472 ProteinModelPortal P60472 http://www.proteinmodelportal.org/query/uniprot/P60472 PubMed 10217761 http://www.ncbi.nlm.nih.gov/pubmed/10217761 PubMed 11076526 http://www.ncbi.nlm.nih.gov/pubmed/11076526 PubMed 11581264 http://www.ncbi.nlm.nih.gov/pubmed/11581264 PubMed 11744728 http://www.ncbi.nlm.nih.gov/pubmed/11744728 PubMed 12756244 http://www.ncbi.nlm.nih.gov/pubmed/12756244 PubMed 15044730 http://www.ncbi.nlm.nih.gov/pubmed/15044730 PubMed 15788389 http://www.ncbi.nlm.nih.gov/pubmed/15788389 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17535895 http://www.ncbi.nlm.nih.gov/pubmed/17535895 PubMed 20828539 http://www.ncbi.nlm.nih.gov/pubmed/20828539 PubMed 21294851 http://www.ncbi.nlm.nih.gov/pubmed/21294851 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9882662 http://www.ncbi.nlm.nih.gov/pubmed/9882662 RefSeq NP_414716 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414716 SMR P60472 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P60472 STRING 511145.b0174 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0174&targetmode=cogs STRING COG0020 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0020&targetmode=cogs SUPFAM SSF64005 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF64005 TIGRFAMs TIGR00055 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00055 UniProtKB UPPS_ECOLI http://www.uniprot.org/uniprot/UPPS_ECOLI UniProtKB-AC P60472 http://www.uniprot.org/uniprot/P60472 charge swissprot:UPPS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UPPS_ECOLI eggNOG COG0020 http://eggnogapi.embl.de/nog_data/html/tree/COG0020 eggNOG ENOG4105CR3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CR3 epestfind swissprot:UPPS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UPPS_ECOLI garnier swissprot:UPPS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UPPS_ECOLI helixturnhelix swissprot:UPPS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UPPS_ECOLI hmoment swissprot:UPPS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UPPS_ECOLI iep swissprot:UPPS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UPPS_ECOLI inforesidue swissprot:UPPS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UPPS_ECOLI octanol swissprot:UPPS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UPPS_ECOLI pepcoil swissprot:UPPS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UPPS_ECOLI pepdigest swissprot:UPPS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UPPS_ECOLI pepinfo swissprot:UPPS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UPPS_ECOLI pepnet swissprot:UPPS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UPPS_ECOLI pepstats swissprot:UPPS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UPPS_ECOLI pepwheel swissprot:UPPS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UPPS_ECOLI pepwindow swissprot:UPPS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UPPS_ECOLI sigcleave swissprot:UPPS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UPPS_ECOLI ## Database ID URL or Descriptions # BioGrid 4262894 5 # CATALYTIC ACTIVITY NARY_ECOLI Nitrite + acceptor = nitrate + reduced acceptor. # COFACTOR NARY_ECOLI Name=[3Fe-4S] cluster; Xref=ChEBI CHEBI 21137; Evidence={ECO 0000250}; Note=Binds 1 [3Fe-4S] cluster per subunit. {ECO 0000250}; # COFACTOR NARY_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000250}; Note=Binds 3 [4Fe-4S] clusters per subunit. {ECO 0000250}; # EcoGene EG10647 narY # FUNCTION NARY_ECOLI This is a second nitrate reductase enzyme which can substitute for the NRA enzyme and allows E.coli to use nitrate as an electron acceptor during anaerobic growth. The beta chain is an electron transfer unit containing four cysteine clusters involved in the formation of iron-sulfur centers. Electrons are transferred from the gamma chain to the molybdenum cofactor of the alpha subunit. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0009325 nitrate reductase complex; IDA:EcoCyc. # GO_component GO:0016020 membrane; IBA:GO_Central. # GO_function GO:0008940 nitrate reductase activity; IDA:EcoCyc. # GO_function GO:0009055 electron carrier activity; ISM:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051536 iron-sulfur cluster binding; ISM:EcoCyc. # GO_function GO:0051538 3 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0009061 anaerobic respiration; IDA:EcoCyc. # GO_process GO:0019645 anaerobic electron transport chain; IDA:EcoCyc. # GO_process GO:0042128 nitrate assimilation; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0006950 response to stress # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0071941 nitrogen cycle metabolic process # Gene3D 1.10.3650.10 -; 1. # INTERACTION NARY_ECOLI P09152 narG; NbExp=3; IntAct=EBI-555059, EBI-547248; P19317 narW; NbExp=3; IntAct=EBI-555059, EBI-555088; # IntAct P19318 14 # InterPro IPR006547 NO3_Rdtase_bsu # InterPro IPR017896 4Fe4S_Fe-S-bd # InterPro IPR029263 Nitr_red_bet_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00910 Nitrogen metabolism # Organism NARY_ECOLI Escherichia coli (strain K12) # PATRIC 32118226 VBIEscCol129921_1533 # PIR F64899 F64899 # PROSITE PS51379 4FE4S_FER_2; 3 # Pfam PF13247 Fer4_11 # Pfam PF14711 Nitr_red_bet_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NARY_ECOLI Respiratory nitrate reductase 2 beta chain # RefSeq NP_415984 NC_000913.3 # RefSeq WP_000702535 NZ_LN832404.1 # SIMILARITY Contains 3 4Fe-4S ferredoxin-type domains. {ECO:0000255|PROSITE-ProRule PRU00711}. # SUBCELLULAR LOCATION NARY_ECOLI Cell membrane; Peripheral membrane protein. # SUBUNIT NARY_ECOLI Dimer of heterotrimers each composed of an alpha, a beta and a gamma chain. Alpha and beta are catalytic chains; gamma chains are involved in binding the enzyme complex to the cytoplasmic membrane. # TCDB 5.A.3.1 the prokaryotic molybdopterin-containing oxidoreductase (pmo) family # TIGRFAMs TIGR01660 narH # eggNOG COG1140 LUCA # eggNOG ENOG4108IUE Bacteria BLAST swissprot:NARY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NARY_ECOLI BioCyc ECOL316407:JW1462-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1462-MONOMER BioCyc EcoCyc:NARY-MONOMER http://biocyc.org/getid?id=EcoCyc:NARY-MONOMER BioCyc MetaCyc:NARY-MONOMER http://biocyc.org/getid?id=MetaCyc:NARY-MONOMER COG COG1140 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1140 DIP DIP-10323N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10323N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.7.99.4 http://www.genome.jp/dbget-bin/www_bget?EC:1.7.99.4 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X17110 http://www.ebi.ac.uk/ena/data/view/X17110 ENZYME 1.7.99.4 http://enzyme.expasy.org/EC/1.7.99.4 EchoBASE EB0641 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0641 EcoGene EG10647 http://www.ecogene.org/geneInfo.php?eg_id=EG10647 EnsemblBacteria AAC74549 http://www.ensemblgenomes.org/id/AAC74549 EnsemblBacteria AAC74549 http://www.ensemblgenomes.org/id/AAC74549 EnsemblBacteria BAA15104 http://www.ensemblgenomes.org/id/BAA15104 EnsemblBacteria BAA15104 http://www.ensemblgenomes.org/id/BAA15104 EnsemblBacteria BAA15104 http://www.ensemblgenomes.org/id/BAA15104 EnsemblBacteria b1467 http://www.ensemblgenomes.org/id/b1467 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0009325 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009325 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0008940 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008940 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051536 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051536 GO_function GO:0051538 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051538 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0009061 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009061 GO_process GO:0019645 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019645 GO_process GO:0042128 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042128 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0071941 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071941 Gene3D 1.10.3650.10 http://www.cathdb.info/version/latest/superfamily/1.10.3650.10 GeneID 946034 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946034 HOGENOM HOG000237353 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000237353&db=HOGENOM6 InParanoid P19318 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P19318 IntAct P19318 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P19318* IntEnz 1.7.99.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.7.99.4 InterPro IPR006547 http://www.ebi.ac.uk/interpro/entry/IPR006547 InterPro IPR017896 http://www.ebi.ac.uk/interpro/entry/IPR017896 InterPro IPR029263 http://www.ebi.ac.uk/interpro/entry/IPR029263 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1462 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1462 KEGG_Gene eco:b1467 http://www.genome.jp/dbget-bin/www_bget?eco:b1467 KEGG_Orthology KO:K08346 http://www.genome.jp/dbget-bin/www_bget?KO:K08346 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Reaction rn:R00798 http://www.genome.jp/dbget-bin/www_bget?rn:R00798 KEGG_Reaction rn:R01106 http://www.genome.jp/dbget-bin/www_bget?rn:R01106 MINT MINT-1251788 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1251788 OMA EPMKVSW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EPMKVSW PROSITE PS51379 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51379 PSORT swissprot:NARY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NARY_ECOLI PSORT-B swissprot:NARY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NARY_ECOLI PSORT2 swissprot:NARY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NARY_ECOLI Pfam PF13247 http://pfam.xfam.org/family/PF13247 Pfam PF14711 http://pfam.xfam.org/family/PF14711 Phobius swissprot:NARY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NARY_ECOLI PhylomeDB P19318 http://phylomedb.org/?seqid=P19318 ProteinModelPortal P19318 http://www.proteinmodelportal.org/query/uniprot/P19318 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2233673 http://www.ncbi.nlm.nih.gov/pubmed/2233673 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415984 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415984 RefSeq WP_000702535 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000702535 SMR P19318 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P19318 STRING 511145.b1467 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1467&targetmode=cogs STRING COG1140 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1140&targetmode=cogs TCDB 5.A.3.1 http://www.tcdb.org/search/result.php?tc=5.A.3.1 TIGRFAMs TIGR01660 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01660 UniProtKB NARY_ECOLI http://www.uniprot.org/uniprot/NARY_ECOLI UniProtKB-AC P19318 http://www.uniprot.org/uniprot/P19318 charge swissprot:NARY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NARY_ECOLI eggNOG COG1140 http://eggnogapi.embl.de/nog_data/html/tree/COG1140 eggNOG ENOG4108IUE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108IUE epestfind swissprot:NARY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NARY_ECOLI garnier swissprot:NARY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NARY_ECOLI helixturnhelix swissprot:NARY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NARY_ECOLI hmoment swissprot:NARY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NARY_ECOLI iep swissprot:NARY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NARY_ECOLI inforesidue swissprot:NARY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NARY_ECOLI octanol swissprot:NARY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NARY_ECOLI pepcoil swissprot:NARY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NARY_ECOLI pepdigest swissprot:NARY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NARY_ECOLI pepinfo swissprot:NARY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NARY_ECOLI pepnet swissprot:NARY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NARY_ECOLI pepstats swissprot:NARY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NARY_ECOLI pepwheel swissprot:NARY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NARY_ECOLI pepwindow swissprot:NARY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NARY_ECOLI sigcleave swissprot:NARY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NARY_ECOLI ## Database ID URL or Descriptions # BioGrid 4261759 15 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG12238 yhiS # Organism YHIS_ECOLI Escherichia coli (strain K12) # PATRIC 48667083 VBIEscCol107702_3807 # PIR S47724 S47724 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHIS_ECOLI Putative uncharacterized protein YhiS # RefSeq WP_000020601 NZ_LN832404.1 BLAST swissprot:YHIS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHIS_ECOLI BioCyc ECOL316407:JW3471-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3471-MONOMER BioCyc EcoCyc:EG12238-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12238-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2150 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2150 EcoGene EG12238 http://www.ecogene.org/geneInfo.php?eg_id=EG12238 EnsemblBacteria BAE77790 http://www.ensemblgenomes.org/id/BAE77790 EnsemblBacteria BAE77790 http://www.ensemblgenomes.org/id/BAE77790 EnsemblBacteria BAE77790 http://www.ensemblgenomes.org/id/BAE77790 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv HOGENOM HOG000009625 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009625&db=HOGENOM6 KEGG_Gene ecj:JW3471 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3471 PSORT swissprot:YHIS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHIS_ECOLI PSORT-B swissprot:YHIS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHIS_ECOLI PSORT2 swissprot:YHIS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHIS_ECOLI Phobius swissprot:YHIS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHIS_ECOLI ProteinModelPortal P37635 http://www.proteinmodelportal.org/query/uniprot/P37635 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000020601 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000020601 UniProtKB YHIS_ECOLI http://www.uniprot.org/uniprot/YHIS_ECOLI UniProtKB-AC P37635 http://www.uniprot.org/uniprot/P37635 charge swissprot:YHIS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHIS_ECOLI epestfind swissprot:YHIS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHIS_ECOLI garnier swissprot:YHIS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHIS_ECOLI helixturnhelix swissprot:YHIS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHIS_ECOLI hmoment swissprot:YHIS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHIS_ECOLI iep swissprot:YHIS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHIS_ECOLI inforesidue swissprot:YHIS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHIS_ECOLI octanol swissprot:YHIS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHIS_ECOLI pepcoil swissprot:YHIS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHIS_ECOLI pepdigest swissprot:YHIS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHIS_ECOLI pepinfo swissprot:YHIS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHIS_ECOLI pepnet swissprot:YHIS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHIS_ECOLI pepstats swissprot:YHIS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHIS_ECOLI pepwheel swissprot:YHIS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHIS_ECOLI pepwindow swissprot:YHIS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHIS_ECOLI sigcleave swissprot:YHIS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHIS_ECOLI ## Database ID URL or Descriptions # CAUTION In E.coli K12, an insertion sequence (IS3E) is inserted in the gatR gene in position 102. {ECO 0000305}. # EcoGene EG12162 gatR # FUNCTION GATR_ECOLI Repressor of the gat operon for galacticol transport and metabolism. # GO_component GO:0005622 intracellular; IEA:InterPro. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_component GO:0005622 intracellular # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # IntAct P36930 8 # InterPro IPR001034 DeoR_HTH # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR014036 DeoR_C # InterPro IPR018356 Tscrpt_reg_HTH_DeoR_CS # Organism GATR_ECOLI Escherichia coli (strain K12) # PRINTS PR00037 HTHLACR # PROSITE PS00894 HTH_DEOR_1 # PROSITE PS51000 HTH_DEOR_2 # Pfam PF00455 DeoRC # Pfam PF08220 HTH_DeoR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GATR_ECOLI Galactitol utilization operon repressor # SEQUENCE CAUTION Sequence=D12598; Type=Frameshift; Positions=117; Evidence={ECO:0000305}; Sequence=X64217; Type=Frameshift; Positions=117; Evidence={ECO 0000305}; # SIMILARITY Contains 1 HTH deoR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00349}. # SMART SM00420 HTH_DEOR # SUPFAM SSF46785 SSF46785 BLAST swissprot:GATR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GATR_ECOLI BioCyc EcoCyc:PD00338 http://biocyc.org/getid?id=EcoCyc:PD00338 BioCyc EcoCyc:PD02366 http://biocyc.org/getid?id=EcoCyc:PD02366 DOI 10.1016/0167-4781(95)00053-J http://dx.doi.org/10.1016/0167-4781(95)00053-J DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D12598 http://www.ebi.ac.uk/ena/data/view/D12598 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X64217 http://www.ebi.ac.uk/ena/data/view/X64217 EMBL X64218 http://www.ebi.ac.uk/ena/data/view/X64218 EMBL X79837 http://www.ebi.ac.uk/ena/data/view/X79837 EchoBASE EB2081 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2081 EcoGene EG12162 http://www.ecogene.org/geneInfo.php?eg_id=EG12162 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 HOGENOM HOG000224684 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000224684&db=HOGENOM6 InParanoid P36930 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P36930 IntAct P36930 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P36930* InterPro IPR001034 http://www.ebi.ac.uk/interpro/entry/IPR001034 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR014036 http://www.ebi.ac.uk/interpro/entry/IPR014036 InterPro IPR018356 http://www.ebi.ac.uk/interpro/entry/IPR018356 PRINTS PR00037 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00037 PROSITE PS00894 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00894 PROSITE PS51000 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51000 PSORT swissprot:GATR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GATR_ECOLI PSORT-B swissprot:GATR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GATR_ECOLI PSORT2 swissprot:GATR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GATR_ECOLI Pfam PF00455 http://pfam.xfam.org/family/PF00455 Pfam PF08220 http://pfam.xfam.org/family/PF08220 Phobius swissprot:GATR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GATR_ECOLI PhylomeDB P36930 http://phylomedb.org/?seqid=P36930 ProteinModelPortal P36930 http://www.proteinmodelportal.org/query/uniprot/P36930 PubMed 1661252 http://www.ncbi.nlm.nih.gov/pubmed/1661252 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7772602 http://www.ncbi.nlm.nih.gov/pubmed/7772602 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SMART SM00420 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00420 SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB GATR_ECOLI http://www.uniprot.org/uniprot/GATR_ECOLI UniProtKB-AC P36930 http://www.uniprot.org/uniprot/P36930 charge swissprot:GATR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GATR_ECOLI epestfind swissprot:GATR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GATR_ECOLI garnier swissprot:GATR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GATR_ECOLI helixturnhelix swissprot:GATR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GATR_ECOLI hmoment swissprot:GATR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GATR_ECOLI iep swissprot:GATR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GATR_ECOLI inforesidue swissprot:GATR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GATR_ECOLI octanol swissprot:GATR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GATR_ECOLI pepcoil swissprot:GATR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GATR_ECOLI pepdigest swissprot:GATR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GATR_ECOLI pepinfo swissprot:GATR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GATR_ECOLI pepnet swissprot:GATR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GATR_ECOLI pepstats swissprot:GATR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GATR_ECOLI pepwheel swissprot:GATR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GATR_ECOLI pepwindow swissprot:GATR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GATR_ECOLI sigcleave swissprot:GATR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GATR_ECOLI ## Database ID URL or Descriptions # AltName YBJG_ECOLI Undecaprenyl pyrophosphate phosphatase # BioGrid 4262827 183 # CATALYTIC ACTIVITY YBJG_ECOLI Ditrans,octacis-undecaprenyl diphosphate + H(2)O = ditrans,octacis-undecaprenyl phosphate + phosphate. # CDD cd03385 PAP2_BcrC_like # EcoGene EG13676 ybjG # FUNCTION YBJG_ECOLI Overexpression leads to increased undecaprenyl diphosphatase activity and to increased resistance to bacitracin. May have a preferred substrate other than undecaprenyl diphosphate in vivo. {ECO 0000269|PubMed 15778224}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0050380 undecaprenyl-diphosphatase activity; IDA:EcoCyc. # GO_process GO:0008360 regulation of cell shape; IEA:UniProtKB-KW. # GO_process GO:0009252 peptidoglycan biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0046677 response to antibiotic; IMP:EcoCyc. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 1.20.144.10 -; 1. # InterPro IPR000326 P_Acid_Pase_2/haloperoxidase # InterPro IPR033879 UPP_Pase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00550 Peptidoglycan biosynthesis # Organism YBJG_ECOLI Escherichia coli (strain K12) # PATRIC 32116885 VBIEscCol129921_0868 # PIR A64822 A64822 # Pfam PF01569 PAP2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBJG_ECOLI Putative undecaprenyl-diphosphatase YbjG # RefSeq NP_415362 NC_000913.3 # RefSeq WP_001295291 NZ_LN832404.1 # SIMILARITY Belongs to the BcrC/YbjG family. {ECO 0000305}. # SMART SM00014 acidPPc # SUBCELLULAR LOCATION YBJG_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF48317 SSF48317 # eggNOG COG0671 LUCA # eggNOG ENOG4105D1E Bacteria BLAST swissprot:YBJG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBJG_ECOLI BioCyc ECOL316407:JW5112-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5112-MONOMER BioCyc EcoCyc:G6439-MONOMER http://biocyc.org/getid?id=EcoCyc:G6439-MONOMER BioCyc MetaCyc:G6439-MONOMER http://biocyc.org/getid?id=MetaCyc:G6439-MONOMER COG COG1968 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1968 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M412277200 http://dx.doi.org/10.1074/jbc.M412277200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.1.27 http://www.genome.jp/dbget-bin/www_bget?EC:3.6.1.27 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.6.1.27 http://enzyme.expasy.org/EC/3.6.1.27 EchoBASE EB3440 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3440 EcoGene EG13676 http://www.ecogene.org/geneInfo.php?eg_id=EG13676 EnsemblBacteria AAC73928 http://www.ensemblgenomes.org/id/AAC73928 EnsemblBacteria AAC73928 http://www.ensemblgenomes.org/id/AAC73928 EnsemblBacteria BAA35544 http://www.ensemblgenomes.org/id/BAA35544 EnsemblBacteria BAA35544 http://www.ensemblgenomes.org/id/BAA35544 EnsemblBacteria BAA35544 http://www.ensemblgenomes.org/id/BAA35544 EnsemblBacteria b0841 http://www.ensemblgenomes.org/id/b0841 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0050380 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050380 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0009252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009252 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 1.20.144.10 http://www.cathdb.info/version/latest/superfamily/1.20.144.10 GeneID 945450 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945450 HOGENOM HOG000221066 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000221066&db=HOGENOM6 InParanoid P75806 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75806 IntEnz 3.6.1.27 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.1.27 InterPro IPR000326 http://www.ebi.ac.uk/interpro/entry/IPR000326 InterPro IPR033879 http://www.ebi.ac.uk/interpro/entry/IPR033879 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5112 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5112 KEGG_Gene eco:b0841 http://www.genome.jp/dbget-bin/www_bget?eco:b0841 KEGG_Orthology KO:K06153 http://www.genome.jp/dbget-bin/www_bget?KO:K06153 KEGG_Pathway ko00550 http://www.genome.jp/kegg-bin/show_pathway?ko00550 KEGG_Reaction rn:R05627 http://www.genome.jp/dbget-bin/www_bget?rn:R05627 OMA WHRVWSG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WHRVWSG PSORT swissprot:YBJG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBJG_ECOLI PSORT-B swissprot:YBJG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBJG_ECOLI PSORT2 swissprot:YBJG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBJG_ECOLI Pfam PF01569 http://pfam.xfam.org/family/PF01569 Phobius swissprot:YBJG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBJG_ECOLI PhylomeDB P75806 http://phylomedb.org/?seqid=P75806 ProteinModelPortal P75806 http://www.proteinmodelportal.org/query/uniprot/P75806 PubMed 15778224 http://www.ncbi.nlm.nih.gov/pubmed/15778224 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415362 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415362 RefSeq WP_001295291 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295291 SMART SM00014 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00014 STRING 511145.b0841 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0841&targetmode=cogs STRING COG1968 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1968&targetmode=cogs SUPFAM SSF48317 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48317 UniProtKB YBJG_ECOLI http://www.uniprot.org/uniprot/YBJG_ECOLI UniProtKB-AC P75806 http://www.uniprot.org/uniprot/P75806 charge swissprot:YBJG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBJG_ECOLI eggNOG COG0671 http://eggnogapi.embl.de/nog_data/html/tree/COG0671 eggNOG ENOG4105D1E http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D1E epestfind swissprot:YBJG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBJG_ECOLI garnier swissprot:YBJG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBJG_ECOLI helixturnhelix swissprot:YBJG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBJG_ECOLI hmoment swissprot:YBJG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBJG_ECOLI iep swissprot:YBJG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBJG_ECOLI inforesidue swissprot:YBJG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBJG_ECOLI octanol swissprot:YBJG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBJG_ECOLI pepcoil swissprot:YBJG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBJG_ECOLI pepdigest swissprot:YBJG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBJG_ECOLI pepinfo swissprot:YBJG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBJG_ECOLI pepnet swissprot:YBJG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBJG_ECOLI pepstats swissprot:YBJG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBJG_ECOLI pepwheel swissprot:YBJG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBJG_ECOLI pepwindow swissprot:YBJG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBJG_ECOLI sigcleave swissprot:YBJG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBJG_ECOLI ## Database ID URL or Descriptions # EcoGene EG13337 yafY # FUNCTION YAFY_ECOLI When overproduced strongly induces degP through the activation of the two-component envelope stress response system CpxA/CpxR (PubMed 15252048). {ECO 0000269|PubMed 15252048}. # GO_component GO:0005886 plasma membrane; IDA:UniProtKB. # GOslim_component GO:0005886 plasma membrane # IntAct P77365 3 # Organism YAFY_ECOLI Escherichia coli (strain K12) # PATRIC 32115619 VBIEscCol129921_0253 # PIR C64750 C64750 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAFY_ECOLI Lipoprotein YafY # RefSeq NP_414785 NC_000913.3 # RefSeq WP_000824223 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB08670.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA77920.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY To E.coli YfjS. {ECO 0000305}. # SUBCELLULAR LOCATION YAFY_ECOLI Cell inner membrane {ECO 0000255|PROSITE- ProRule PRU00303, ECO 0000269|PubMed 15252048}; Lipid-anchor {ECO 0000255|PROSITE-ProRule PRU00303, ECO 0000305|PubMed 15252048}. # eggNOG COG2378 LUCA BLAST swissprot:YAFY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAFY_ECOLI BioCyc ECOL316407:JW0240-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0240-MONOMER BioCyc EcoCyc:G6126-MONOMER http://biocyc.org/getid?id=EcoCyc:G6126-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M406390200 http://dx.doi.org/10.1074/jbc.M406390200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EchoBASE EB3121 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3121 EcoGene EG13337 http://www.ecogene.org/geneInfo.php?eg_id=EG13337 EnsemblBacteria AAC73354 http://www.ensemblgenomes.org/id/AAC73354 EnsemblBacteria AAC73354 http://www.ensemblgenomes.org/id/AAC73354 EnsemblBacteria BAA77920 http://www.ensemblgenomes.org/id/BAA77920 EnsemblBacteria BAA77920 http://www.ensemblgenomes.org/id/BAA77920 EnsemblBacteria BAA77920 http://www.ensemblgenomes.org/id/BAA77920 EnsemblBacteria b0251 http://www.ensemblgenomes.org/id/b0251 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 944934 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944934 HOGENOM HOG000028675 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000028675&db=HOGENOM6 IntAct P77365 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77365* KEGG_Gene ecj:JW0240 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0240 KEGG_Gene eco:b0251 http://www.genome.jp/dbget-bin/www_bget?eco:b0251 PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YAFY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAFY_ECOLI PSORT-B swissprot:YAFY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAFY_ECOLI PSORT2 swissprot:YAFY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAFY_ECOLI Phobius swissprot:YAFY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAFY_ECOLI ProteinModelPortal P77365 http://www.proteinmodelportal.org/query/uniprot/P77365 PubMed 15252048 http://www.ncbi.nlm.nih.gov/pubmed/15252048 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414785 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414785 RefSeq WP_000824223 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000824223 SMR P77365 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77365 STRING 511145.b0251 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0251&targetmode=cogs UniProtKB YAFY_ECOLI http://www.uniprot.org/uniprot/YAFY_ECOLI UniProtKB-AC P77365 http://www.uniprot.org/uniprot/P77365 charge swissprot:YAFY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAFY_ECOLI eggNOG COG2378 http://eggnogapi.embl.de/nog_data/html/tree/COG2378 epestfind swissprot:YAFY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAFY_ECOLI garnier swissprot:YAFY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAFY_ECOLI helixturnhelix swissprot:YAFY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAFY_ECOLI hmoment swissprot:YAFY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAFY_ECOLI iep swissprot:YAFY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAFY_ECOLI inforesidue swissprot:YAFY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAFY_ECOLI octanol swissprot:YAFY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAFY_ECOLI pepcoil swissprot:YAFY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAFY_ECOLI pepdigest swissprot:YAFY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAFY_ECOLI pepinfo swissprot:YAFY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAFY_ECOLI pepnet swissprot:YAFY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAFY_ECOLI pepstats swissprot:YAFY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAFY_ECOLI pepwheel swissprot:YAFY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAFY_ECOLI pepwindow swissprot:YAFY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAFY_ECOLI sigcleave swissprot:YAFY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAFY_ECOLI ## Database ID URL or Descriptions # AltName SSUD_ECOLI FMNH2-dependent aliphatic sulfonate monooxygenase # AltName SSUD_ECOLI Sulfate starvation-induced protein 6 # BioGrid 4260022 10 # CATALYTIC ACTIVITY SSUD_ECOLI An alkanesulfonate (R-CH(2)-SO(3)H) + FMNH(2) + O(2) = an aldehyde (R-CHO) + FMN + sulfite + H(2)O. # EcoGene EG13706 ssuD # FUNCTION SSUD_ECOLI Involved in desulfonation of aliphatic sulfonates. Catalyzes the conversion of pentanesulfonic acid to sulfite and pentaldehyde and is able to desulfonate a wide range of sulfonated substrates including C-2 to C-10 unsubstituted linear alkanesulfonates, substituted ethanesulfonic acids and sulfonated buffers. # GO_function GO:0008726 alkanesulfonate monooxygenase activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0009408 response to heat; IMP:EcoCyc. # GO_process GO:0046306 alkanesulfonate catabolic process; IMP:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009056 catabolic process # Gene3D 3.20.20.30 -; 2. # HAMAP MF_01229 Alkanesulf_monooxygen # INDUCTION SSUD_ECOLI Repressed by sulfate or cysteine. # INTERACTION SSUD_ECOLI P80644 ssuE; NbExp=2; IntAct=EBI-561637, EBI-1121047; # IntAct P80645 10 # InterPro IPR011251 Luciferase-like_dom # InterPro IPR019911 Alkanesulphonate_mOase_FMN-dep # KEGG_Brite ko01000 Enzymes # MISCELLANEOUS SSUD_ECOLI FMNH(2) which is absolutely required for this enzymatic reaction, is provided by SsuE. # Organism SSUD_ECOLI Escherichia coli (strain K12) # PATRIC 32117089 VBIEscCol129921_0969 # PDB 1M41 X-ray; 2.30 A; A/B=2-381 # PDB 1NQK X-ray; 2.20 A; A=1-381 # PIR F64833 F64833 # Pfam PF00296 Bac_luciferase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SSUD_ECOLI Alkanesulfonate monooxygenase # RefSeq NP_415455 NC_000913.3 # RefSeq WP_000056006 NZ_LN832404.1 # SIMILARITY Belongs to the SsuD family. {ECO 0000305}. # SUBUNIT SSUD_ECOLI Homotetramer. # SUPFAM SSF51679 SSF51679 # TIGRFAMs TIGR03565 alk_sulf_monoox # eggNOG COG2141 LUCA # eggNOG ENOG4105D4R Bacteria BLAST swissprot:SSUD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SSUD_ECOLI BioCyc ECOL316407:JW0918-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0918-MONOMER BioCyc EcoCyc:MONOMER-162 http://biocyc.org/getid?id=EcoCyc:MONOMER-162 BioCyc MetaCyc:MONOMER-162 http://biocyc.org/getid?id=MetaCyc:MONOMER-162 COG COG2141 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2141 DIP DIP-10928N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10928N DOI 10.1016/S0022-2836(02)01069-0 http://dx.doi.org/10.1016/S0022-2836(02)01069-0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.274.38.26639 http://dx.doi.org/10.1074/jbc.274.38.26639 DOI 10.1074/jbc.274.41.29358 http://dx.doi.org/10.1074/jbc.274.41.29358 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1432-1033.1996.0773u.x http://dx.doi.org/10.1111/j.1432-1033.1996.0773u.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.14.14.5 http://www.genome.jp/dbget-bin/www_bget?EC:1.14.14.5 EMBL AJ237695 http://www.ebi.ac.uk/ena/data/view/AJ237695 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.14.14.5 http://enzyme.expasy.org/EC/1.14.14.5 EchoBASE EB3470 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3470 EcoGene EG13706 http://www.ecogene.org/geneInfo.php?eg_id=EG13706 EnsemblBacteria AAC74021 http://www.ensemblgenomes.org/id/AAC74021 EnsemblBacteria AAC74021 http://www.ensemblgenomes.org/id/AAC74021 EnsemblBacteria BAA35690 http://www.ensemblgenomes.org/id/BAA35690 EnsemblBacteria BAA35690 http://www.ensemblgenomes.org/id/BAA35690 EnsemblBacteria BAA35690 http://www.ensemblgenomes.org/id/BAA35690 EnsemblBacteria b0935 http://www.ensemblgenomes.org/id/b0935 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008726 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008726 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GO_process GO:0046306 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046306 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 3.20.20.30 http://www.cathdb.info/version/latest/superfamily/3.20.20.30 GeneID 945557 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945557 HAMAP MF_01229 http://hamap.expasy.org/unirule/MF_01229 HOGENOM HOG000134568 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000134568&db=HOGENOM6 InParanoid P80645 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P80645 IntAct P80645 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P80645* IntEnz 1.14.14.5 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.14.14.5 InterPro IPR011251 http://www.ebi.ac.uk/interpro/entry/IPR011251 InterPro IPR019911 http://www.ebi.ac.uk/interpro/entry/IPR019911 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0918 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0918 KEGG_Gene eco:b0935 http://www.genome.jp/dbget-bin/www_bget?eco:b0935 KEGG_Orthology KO:K04091 http://www.genome.jp/dbget-bin/www_bget?KO:K04091 OMA DYDGKHI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DYDGKHI PDB 1M41 http://www.ebi.ac.uk/pdbe-srv/view/entry/1M41 PDB 1NQK http://www.ebi.ac.uk/pdbe-srv/view/entry/1NQK PDBsum 1M41 http://www.ebi.ac.uk/pdbsum/1M41 PDBsum 1NQK http://www.ebi.ac.uk/pdbsum/1NQK PSORT swissprot:SSUD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SSUD_ECOLI PSORT-B swissprot:SSUD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SSUD_ECOLI PSORT2 swissprot:SSUD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SSUD_ECOLI Pfam PF00296 http://pfam.xfam.org/family/PF00296 Phobius swissprot:SSUD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SSUD_ECOLI PhylomeDB P80645 http://phylomedb.org/?seqid=P80645 ProteinModelPortal P80645 http://www.proteinmodelportal.org/query/uniprot/P80645 PubMed 10480865 http://www.ncbi.nlm.nih.gov/pubmed/10480865 PubMed 10506196 http://www.ncbi.nlm.nih.gov/pubmed/10506196 PubMed 12445781 http://www.ncbi.nlm.nih.gov/pubmed/12445781 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8774726 http://www.ncbi.nlm.nih.gov/pubmed/8774726 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415455 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415455 RefSeq WP_000056006 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000056006 SMR P80645 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P80645 STRING 511145.b0935 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0935&targetmode=cogs STRING COG2141 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2141&targetmode=cogs SUPFAM SSF51679 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51679 TIGRFAMs TIGR03565 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03565 UniProtKB SSUD_ECOLI http://www.uniprot.org/uniprot/SSUD_ECOLI UniProtKB-AC P80645 http://www.uniprot.org/uniprot/P80645 charge swissprot:SSUD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SSUD_ECOLI eggNOG COG2141 http://eggnogapi.embl.de/nog_data/html/tree/COG2141 eggNOG ENOG4105D4R http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D4R epestfind swissprot:SSUD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SSUD_ECOLI garnier swissprot:SSUD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SSUD_ECOLI helixturnhelix swissprot:SSUD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SSUD_ECOLI hmoment swissprot:SSUD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SSUD_ECOLI iep swissprot:SSUD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SSUD_ECOLI inforesidue swissprot:SSUD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SSUD_ECOLI octanol swissprot:SSUD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SSUD_ECOLI pepcoil swissprot:SSUD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SSUD_ECOLI pepdigest swissprot:SSUD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SSUD_ECOLI pepinfo swissprot:SSUD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SSUD_ECOLI pepnet swissprot:SSUD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SSUD_ECOLI pepstats swissprot:SSUD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SSUD_ECOLI pepwheel swissprot:SSUD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SSUD_ECOLI pepwindow swissprot:SSUD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SSUD_ECOLI sigcleave swissprot:SSUD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SSUD_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES MASZ_ECOLI Kinetic parameters KM=9 uM for acetyl-CoA (at pH 8 and 37 degrees Celsius) {ECO 0000269|PubMed 12930982}; KM=21 uM for glyoxylate (at pH 8 and 37 degrees Celsius) {ECO 0000269|PubMed 12930982}; Vmax=36.1 umol/min/mg enzyme (at pH 8 and 37 degrees Celsius) {ECO 0000269|PubMed 12930982}; Note=Kcat is 48.1 sec(-1) for glyoxylate (at pH 8 and 37 degrees Celsius).; # BRENDA 2.3.3 2026 # BioGrid 4259239 14 # CATALYTIC ACTIVITY Acetyl-CoA + H(2)O + glyoxylate = (S)-malate + CoA. {ECO:0000255|HAMAP-Rule MF_00641}. # CDD cd00728 malate_synt_G # COFACTOR MASZ_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_00641, ECO 0000269|PubMed 10715138}; # DISRUPTION PHENOTYPE Cells lacking this gene are unable to oxidize glyoxylate. {ECO:0000269|PubMed 4892366}. # DrugBank DB01638 D-Sorbitol # EcoGene EG20080 glcB # FUNCTION MASZ_ECOLI Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA. {ECO 0000255|HAMAP-Rule MF_00641, ECO 0000269|PubMed 14336062, ECO 0000269|PubMed 4892366, ECO 0000269|PubMed 7925370}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004474 malate synthase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006097 glyoxylate cycle; IBA:GO_Central. # GO_process GO:0006099 tricarboxylic acid cycle; IEA:UniProtKB-KW. # GO_process GO:0009436 glyoxylate catabolic process; IEP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 2.170.170.11 -; 2. # HAMAP MF_00641 Malate_synth_G # INDUCTION MASZ_ECOLI By glycolate. {ECO 0000269|PubMed 4892366, ECO 0000269|PubMed 7925370, ECO 0000269|PubMed 9880556}. # IntAct P37330 6 # InterPro IPR001465 Malate_synthase # InterPro IPR006253 Malate_synthG # InterPro IPR011076 Malate_synth-like # InterPro IPR023310 Malate_synth_G_beta_sub_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00620 Pyruvate metabolism # KEGG_Pathway ko00630 Glyoxylate and dicarboxylate metabolism # Organism MASZ_ECOLI Escherichia coli (strain K12) # PATHWAY Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2. {ECO 0000255|HAMAP-Rule:MF_00641}. # PATRIC 32121366 VBIEscCol129921_3070 # PDB 1D8C X-ray; 2.00 A; A=1-723 # PDB 1P7T X-ray; 1.95 A; A/B=3-723 # PDB 1Y8B NMR; -; A=1-723 # PDB 2JQX NMR; -; A=1-723 # PIR S51788 S51788 # Pfam PF01274 Malate_synthase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Malate synthase G {ECO:0000255|HAMAP-Rule MF_00641} # RefSeq NP_417450 NC_000913.3 # RefSeq WP_000084131 NZ_LN832404.1 # SIMILARITY Belongs to the malate synthase family. GlcB subfamily. {ECO:0000255|HAMAP-Rule MF_00641}. # SUBCELLULAR LOCATION MASZ_ECOLI Cytoplasm. # SUBUNIT MASZ_ECOLI Monomer. {ECO 0000255|HAMAP-Rule MF_00641, ECO 0000269|PubMed 10715138, ECO 0000269|PubMed 12930982, ECO 0000269|PubMed 15637152, ECO 0000269|PubMed 7925370}. # SUPFAM SSF51645 SSF51645 # TIGRFAMs TIGR01345 malate_syn_G # UniPathway UPA00703 UER00720 # eggNOG COG2225 LUCA # eggNOG ENOG4107QP3 Bacteria BLAST swissprot:MASZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MASZ_ECOLI BioCyc ECOL316407:JW2943-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2943-MONOMER BioCyc EcoCyc:MALSYNG-MONOMER http://biocyc.org/getid?id=EcoCyc:MALSYNG-MONOMER BioCyc MetaCyc:MALSYNG-MONOMER http://biocyc.org/getid?id=MetaCyc:MALSYNG-MONOMER COG COG2225 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2225 DIP DIP-9761N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9761N DOI 10.1007/s10858-007-9211-5 http://dx.doi.org/10.1007/s10858-007-9211-5 DOI 10.1021/bi992519h http://dx.doi.org/10.1021/bi992519h DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0407792102 http://dx.doi.org/10.1073/pnas.0407792102 DOI 10.1074/jbc.274.3.1745 http://dx.doi.org/10.1074/jbc.274.3.1745 DOI 10.1110/ps.03174303 http://dx.doi.org/10.1110/ps.03174303 DOI 10.1111/j.1432-1033.1994.00541.x http://dx.doi.org/10.1111/j.1432-1033.1994.00541.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB01638 http://www.drugbank.ca/drugs/DB01638 EC_number EC:2.3.3.9 {ECO:0000255|HAMAP-Rule:MF_00641} http://www.genome.jp/dbget-bin/www_bget?EC:2.3.3.9 {ECO:0000255|HAMAP-Rule:MF_00641} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EMBL X74547 http://www.ebi.ac.uk/ena/data/view/X74547 ENZYME 2.3.3.9 {ECO:0000255|HAMAP-Rule:MF_00641} http://enzyme.expasy.org/EC/2.3.3.9 {ECO:0000255|HAMAP-Rule:MF_00641} EchoBASE EB4141 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4141 EcoGene EG20080 http://www.ecogene.org/geneInfo.php?eg_id=EG20080 EnsemblBacteria AAC76012 http://www.ensemblgenomes.org/id/AAC76012 EnsemblBacteria AAC76012 http://www.ensemblgenomes.org/id/AAC76012 EnsemblBacteria BAE77036 http://www.ensemblgenomes.org/id/BAE77036 EnsemblBacteria BAE77036 http://www.ensemblgenomes.org/id/BAE77036 EnsemblBacteria BAE77036 http://www.ensemblgenomes.org/id/BAE77036 EnsemblBacteria b2976 http://www.ensemblgenomes.org/id/b2976 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004474 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004474 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006097 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006097 GO_process GO:0006099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006099 GO_process GO:0009436 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009436 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 2.170.170.11 http://www.cathdb.info/version/latest/superfamily/2.170.170.11 GeneID 948857 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948857 HAMAP MF_00641 http://hamap.expasy.org/unirule/MF_00641 HOGENOM HOG000220740 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220740&db=HOGENOM6 InParanoid P37330 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37330 IntAct P37330 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37330* IntEnz 2.3.3.9 {ECO:0000255|HAMAP-Rule:MF_00641} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.3.9 {ECO:0000255|HAMAP-Rule:MF_00641} InterPro IPR001465 http://www.ebi.ac.uk/interpro/entry/IPR001465 InterPro IPR006253 http://www.ebi.ac.uk/interpro/entry/IPR006253 InterPro IPR011076 http://www.ebi.ac.uk/interpro/entry/IPR011076 InterPro IPR023310 http://www.ebi.ac.uk/interpro/entry/IPR023310 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2943 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2943 KEGG_Gene eco:b2976 http://www.genome.jp/dbget-bin/www_bget?eco:b2976 KEGG_Orthology KO:K01638 http://www.genome.jp/dbget-bin/www_bget?KO:K01638 KEGG_Pathway ko00620 http://www.genome.jp/kegg-bin/show_pathway?ko00620 KEGG_Pathway ko00630 http://www.genome.jp/kegg-bin/show_pathway?ko00630 KEGG_Reaction rn:R00472 http://www.genome.jp/dbget-bin/www_bget?rn:R00472 MINT MINT-1248166 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1248166 OMA GYNEVRG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GYNEVRG PDB 1D8C http://www.ebi.ac.uk/pdbe-srv/view/entry/1D8C PDB 1P7T http://www.ebi.ac.uk/pdbe-srv/view/entry/1P7T PDB 1Y8B http://www.ebi.ac.uk/pdbe-srv/view/entry/1Y8B PDB 2JQX http://www.ebi.ac.uk/pdbe-srv/view/entry/2JQX PDBsum 1D8C http://www.ebi.ac.uk/pdbsum/1D8C PDBsum 1P7T http://www.ebi.ac.uk/pdbsum/1P7T PDBsum 1Y8B http://www.ebi.ac.uk/pdbsum/1Y8B PDBsum 2JQX http://www.ebi.ac.uk/pdbsum/2JQX PSORT swissprot:MASZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MASZ_ECOLI PSORT-B swissprot:MASZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MASZ_ECOLI PSORT2 swissprot:MASZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MASZ_ECOLI Pfam PF01274 http://pfam.xfam.org/family/PF01274 Phobius swissprot:MASZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MASZ_ECOLI PhylomeDB P37330 http://phylomedb.org/?seqid=P37330 ProteinModelPortal P37330 http://www.proteinmodelportal.org/query/uniprot/P37330 PubMed 10715138 http://www.ncbi.nlm.nih.gov/pubmed/10715138 PubMed 12930982 http://www.ncbi.nlm.nih.gov/pubmed/12930982 PubMed 14336062 http://www.ncbi.nlm.nih.gov/pubmed/14336062 PubMed 15637152 http://www.ncbi.nlm.nih.gov/pubmed/15637152 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18008171 http://www.ncbi.nlm.nih.gov/pubmed/18008171 PubMed 4892366 http://www.ncbi.nlm.nih.gov/pubmed/4892366 PubMed 7925370 http://www.ncbi.nlm.nih.gov/pubmed/7925370 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9880556 http://www.ncbi.nlm.nih.gov/pubmed/9880556 RefSeq NP_417450 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417450 RefSeq WP_000084131 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000084131 SMR P37330 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37330 STRING 511145.b2976 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2976&targetmode=cogs STRING COG2225 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2225&targetmode=cogs SUPFAM SSF51645 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51645 TIGRFAMs TIGR01345 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01345 UniProtKB MASZ_ECOLI http://www.uniprot.org/uniprot/MASZ_ECOLI UniProtKB-AC P37330 http://www.uniprot.org/uniprot/P37330 charge swissprot:MASZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MASZ_ECOLI eggNOG COG2225 http://eggnogapi.embl.de/nog_data/html/tree/COG2225 eggNOG ENOG4107QP3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QP3 epestfind swissprot:MASZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MASZ_ECOLI garnier swissprot:MASZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MASZ_ECOLI helixturnhelix swissprot:MASZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MASZ_ECOLI hmoment swissprot:MASZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MASZ_ECOLI iep swissprot:MASZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MASZ_ECOLI inforesidue swissprot:MASZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MASZ_ECOLI octanol swissprot:MASZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MASZ_ECOLI pepcoil swissprot:MASZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MASZ_ECOLI pepdigest swissprot:MASZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MASZ_ECOLI pepinfo swissprot:MASZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MASZ_ECOLI pepnet swissprot:MASZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MASZ_ECOLI pepstats swissprot:MASZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MASZ_ECOLI pepwheel swissprot:MASZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MASZ_ECOLI pepwindow swissprot:MASZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MASZ_ECOLI sigcleave swissprot:MASZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MASZ_ECOLI ## Database ID URL or Descriptions # AltName YCCE_ECOLI ORF-D # BioGrid 4260040 10 # EcoGene EG12196 yccE # Organism YCCE_ECOLI Escherichia coli (strain K12) # PATRIC 32117227 VBIEscCol129921_1037 # PIR G64841 G64841 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCCE_ECOLI Uncharacterized protein YccE # RefSeq NP_415521 NC_000913.3 # RefSeq WP_000535346 NZ_LN832404.1 BLAST swissprot:YCCE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCCE_ECOLI BioCyc ECOL316407:JW0986-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0986-MONOMER BioCyc EcoCyc:EG12196-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12196-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.91.3.1054 http://dx.doi.org/10.1073/pnas.91.3.1054 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D16500 http://www.ebi.ac.uk/ena/data/view/D16500 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2113 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2113 EcoGene EG12196 http://www.ecogene.org/geneInfo.php?eg_id=EG12196 EnsemblBacteria AAC74086 http://www.ensemblgenomes.org/id/AAC74086 EnsemblBacteria AAC74086 http://www.ensemblgenomes.org/id/AAC74086 EnsemblBacteria BAA35768 http://www.ensemblgenomes.org/id/BAA35768 EnsemblBacteria BAA35768 http://www.ensemblgenomes.org/id/BAA35768 EnsemblBacteria BAA35768 http://www.ensemblgenomes.org/id/BAA35768 EnsemblBacteria b1001 http://www.ensemblgenomes.org/id/b1001 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947468 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947468 HOGENOM HOG000009404 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009404&db=HOGENOM6 IntAct P36661 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P36661* KEGG_Gene ecj:JW0986 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0986 KEGG_Gene eco:b1001 http://www.genome.jp/dbget-bin/www_bget?eco:b1001 OMA WNNIKNE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WNNIKNE PSORT swissprot:YCCE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCCE_ECOLI PSORT-B swissprot:YCCE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCCE_ECOLI PSORT2 swissprot:YCCE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCCE_ECOLI Phobius swissprot:YCCE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCCE_ECOLI ProteinModelPortal P36661 http://www.proteinmodelportal.org/query/uniprot/P36661 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8302830 http://www.ncbi.nlm.nih.gov/pubmed/8302830 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415521 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415521 RefSeq WP_000535346 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000535346 SMR P36661 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P36661 STRING 511145.b1001 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1001&targetmode=cogs UniProtKB YCCE_ECOLI http://www.uniprot.org/uniprot/YCCE_ECOLI UniProtKB-AC P36661 http://www.uniprot.org/uniprot/P36661 charge swissprot:YCCE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCCE_ECOLI epestfind swissprot:YCCE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCCE_ECOLI garnier swissprot:YCCE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCCE_ECOLI helixturnhelix swissprot:YCCE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCCE_ECOLI hmoment swissprot:YCCE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCCE_ECOLI iep swissprot:YCCE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCCE_ECOLI inforesidue swissprot:YCCE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCCE_ECOLI octanol swissprot:YCCE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCCE_ECOLI pepcoil swissprot:YCCE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCCE_ECOLI pepdigest swissprot:YCCE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCCE_ECOLI pepinfo swissprot:YCCE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCCE_ECOLI pepnet swissprot:YCCE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCCE_ECOLI pepstats swissprot:YCCE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCCE_ECOLI pepwheel swissprot:YCCE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCCE_ECOLI pepwindow swissprot:YCCE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCCE_ECOLI sigcleave swissprot:YCCE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCCE_ECOLI ## Database ID URL or Descriptions # BioGrid 4260110 12 # BioGrid 4262866 14 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG13890 ycgI # GO_component GO:0019867 outer membrane; IEA:InterPro. # GO_process GO:0007155 cell adhesion; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0007155 cell adhesion # Gene3D 2.40.128.130 -; 1. # InterPro IPR003991 Pertactin_virulence_factor # InterPro IPR005546 Autotransporte_beta # InterPro IPR006315 OM_autotransptr_brl # Organism YCGI_ECOLI Escherichia coli (strain K12) # PATRIC 48661609 VBIEscCol107702_1172 # PIR B64863 B64863 # PRINTS PR01484 PRTACTNFAMLY # Pfam PF03797 Autotransporter # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCGI_ECOLI Putative uncharacterized protein YcgI # SEQUENCE CAUTION Sequence=BAE76389.1; Type=Frameshift; Positions=70; Evidence={ECO:0000305}; Sequence=BAE76390.1; Type=Frameshift; Positions=70; Evidence={ECO 0000305}; Sequence=U00096; Type=Frameshift; Positions=70; Evidence={ECO:0000305}; # SUPFAM SSF103515 SSF103515 # TIGRFAMs TIGR01414 autotrans_barl BLAST swissprot:YCGI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCGI_ECOLI BioCyc ECOL316407:JW1162-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1162-MONOMER BioCyc ECOL316407:JW5179-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5179-MONOMER BioCyc EcoCyc:G6613-MONOMER http://biocyc.org/getid?id=EcoCyc:G6613-MONOMER BioCyc EcoCyc:MONOMER0-2666 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2666 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG13890 http://www.ecogene.org/geneInfo.php?eg_id=EG13890 EnsemblBacteria BAE76389 http://www.ensemblgenomes.org/id/BAE76389 EnsemblBacteria BAE76389 http://www.ensemblgenomes.org/id/BAE76389 EnsemblBacteria BAE76389 http://www.ensemblgenomes.org/id/BAE76389 EnsemblBacteria BAE76390 http://www.ensemblgenomes.org/id/BAE76390 EnsemblBacteria BAE76390 http://www.ensemblgenomes.org/id/BAE76390 EnsemblBacteria BAE76390 http://www.ensemblgenomes.org/id/BAE76390 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0019867 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019867 GO_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 Gene3D 2.40.128.130 http://www.cathdb.info/version/latest/superfamily/2.40.128.130 HOGENOM HOG000119724 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000119724&db=HOGENOM6 InterPro IPR003991 http://www.ebi.ac.uk/interpro/entry/IPR003991 InterPro IPR005546 http://www.ebi.ac.uk/interpro/entry/IPR005546 InterPro IPR006315 http://www.ebi.ac.uk/interpro/entry/IPR006315 KEGG_Gene ecj:JW1162 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1162 KEGG_Gene ecj:JW5179 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5179 OMA VAGANWS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VAGANWS PRINTS PR01484 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01484 PSORT swissprot:YCGI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCGI_ECOLI PSORT-B swissprot:YCGI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCGI_ECOLI PSORT2 swissprot:YCGI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCGI_ECOLI Pfam PF03797 http://pfam.xfam.org/family/PF03797 Phobius swissprot:YCGI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCGI_ECOLI ProteinModelPortal P76000 http://www.proteinmodelportal.org/query/uniprot/P76000 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SUPFAM SSF103515 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103515 TIGRFAMs TIGR01414 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01414 UniProtKB YCGI_ECOLI http://www.uniprot.org/uniprot/YCGI_ECOLI UniProtKB-AC P76000 http://www.uniprot.org/uniprot/P76000 charge swissprot:YCGI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCGI_ECOLI epestfind swissprot:YCGI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCGI_ECOLI garnier swissprot:YCGI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCGI_ECOLI helixturnhelix swissprot:YCGI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCGI_ECOLI hmoment swissprot:YCGI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCGI_ECOLI iep swissprot:YCGI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCGI_ECOLI inforesidue swissprot:YCGI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCGI_ECOLI octanol swissprot:YCGI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCGI_ECOLI pepcoil swissprot:YCGI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCGI_ECOLI pepdigest swissprot:YCGI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCGI_ECOLI pepinfo swissprot:YCGI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCGI_ECOLI pepnet swissprot:YCGI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCGI_ECOLI pepstats swissprot:YCGI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCGI_ECOLI pepwheel swissprot:YCGI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCGI_ECOLI pepwindow swissprot:YCGI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCGI_ECOLI sigcleave swissprot:YCGI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCGI_ECOLI ## Database ID URL or Descriptions # AltName CHPB_ECOLI Toxin ChpB # AltName CHPB_ECOLI mRNA interferase ChpB # BioGrid 4259311 4 # DISRUPTION PHENOTYPE CHPB_ECOLI No visible phenotype. {ECO 0000269|PubMed 12972253, ECO 0000269|PubMed 8083180}. # ENZYME REGULATION Stimulated in vitro in a concentration- dependent fashion by extracellular death factor (EDF, a quorum sensing pentapeptide sequence NNWNN, probably produced from the zwf gene product glucose-6-phosphate 1-dehydrogenase), which is able to overcome inhibition by cognate antitoxin ChpS. {ECO:0000269|PubMed 21419338}. # EcoGene EG12096 chpB # FUNCTION CHPB_ECOLI Toxic component of a type II toxin-antitoxin (TA) module. ChpB is a sequence-specific mRNA and (weak) tmRNA endoribonuclease that inhibits protein synthesis and induces bacterial stasis. Cleavage is independent of the ribosome. Cleavage occurs at ACY sequences where Y is not C. The endoribonuclease activity is not as strong as that of MazF. The endoribonuclease activity (a toxin) is inhibited by its labile cognate antitoxin ChpS. Toxicity results when the levels of ChpS decrease in the cell, leading to mRNA degradation. Both ChpS and ChpB probably bind to the promoter region of the chpS-chpB operon to autoregulate their synthesis. {ECO 0000269|PubMed 12972253, ECO 0000269|PubMed 16413033, ECO 0000269|PubMed 21419338, ECO 0000269|PubMed 8226627}. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003723 RNA binding; IEA:UniProtKB-KW. # GO_function GO:0004521 endoribonuclease activity; IDA:UniProtKB. # GO_function GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters; IDA:EcoCyc. # GO_process GO:0030308 negative regulation of cell growth; IMP:EcoCyc. # GO_process GO:0043488 regulation of mRNA stability; IDA:UniProtKB. # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0004518 nuclease activity # GOslim_process GO:0008150 biological_process # Gene3D 2.30.30.110 -; 1. # INDUCTION Part of the chpS-chpB operon. {ECO:0000269|PubMed 8226627}. # InterPro IPR003477 PemK-like # InterPro IPR011067 Plasmid_toxin/cell-grow_inhib # KEGG_Brite ko01000 Enzymes # Organism CHPB_ECOLI Escherichia coli (strain K12) # PATRIC 32124025 VBIEscCol129921_4357 # PIR D49339 D49339 # Pfam PF02452 PemK_toxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CHPB_ECOLI Endoribonuclease ChpB # RefSeq NP_418646 NC_000913.3 # RefSeq WP_000239577 NZ_LN832404.1 # SIMILARITY Belongs to the PemK/MazF family. {ECO 0000305}. # SUBUNIT Homodimer, interacts with ChpS, which inhibits the endoribonuclease activity. {ECO:0000269|PubMed 16413033}. # SUPFAM SSF50118 SSF50118 # eggNOG COG2337 LUCA # eggNOG ENOG4105MZG Bacteria BLAST swissprot:CHPB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CHPB_ECOLI BioCyc ECOL316407:JW4184-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4184-MONOMER BioCyc EcoCyc:EG12096-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12096-MONOMER BioCyc MetaCyc:EG12096-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12096-MONOMER COG COG2337 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2337 DOI 10.1016/S0022-2836(03)00922-7 http://dx.doi.org/10.1016/S0022-2836(03)00922-7 DOI 10.1016/j.jmb.2005.12.033 http://dx.doi.org/10.1016/j.jmb.2005.12.033 DOI 10.1016/j.molcel.2011.02.023 http://dx.doi.org/10.1016/j.molcel.2011.02.023 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D16451 http://www.ebi.ac.uk/ena/data/view/D16451 EMBL M14018 http://www.ebi.ac.uk/ena/data/view/M14018 EMBL M23550 http://www.ebi.ac.uk/ena/data/view/M23550 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 3.1.-.- http://enzyme.expasy.org/EC/3.1.-.- EchoBASE EB2020 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2020 EcoGene EG12096 http://www.ecogene.org/geneInfo.php?eg_id=EG12096 EnsemblBacteria AAC77182 http://www.ensemblgenomes.org/id/AAC77182 EnsemblBacteria AAC77182 http://www.ensemblgenomes.org/id/AAC77182 EnsemblBacteria BAE78226 http://www.ensemblgenomes.org/id/BAE78226 EnsemblBacteria BAE78226 http://www.ensemblgenomes.org/id/BAE78226 EnsemblBacteria BAE78226 http://www.ensemblgenomes.org/id/BAE78226 EnsemblBacteria b4225 http://www.ensemblgenomes.org/id/b4225 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0004521 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004521 GO_function GO:0016891 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016891 GO_process GO:0030308 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030308 GO_process GO:0043488 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043488 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 2.30.30.110 http://www.cathdb.info/version/latest/superfamily/2.30.30.110 GeneID 948747 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948747 HOGENOM HOG000290185 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000290185&db=HOGENOM6 InParanoid P33647 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33647 IntEnz 3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1 InterPro IPR003477 http://www.ebi.ac.uk/interpro/entry/IPR003477 InterPro IPR011067 http://www.ebi.ac.uk/interpro/entry/IPR011067 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4184 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4184 KEGG_Gene eco:b4225 http://www.genome.jp/dbget-bin/www_bget?eco:b4225 KEGG_Orthology KO:K07171 http://www.genome.jp/dbget-bin/www_bget?KO:K07171 OMA MIDYIER http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MIDYIER PSORT swissprot:CHPB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CHPB_ECOLI PSORT-B swissprot:CHPB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CHPB_ECOLI PSORT2 swissprot:CHPB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CHPB_ECOLI Pfam PF02452 http://pfam.xfam.org/family/PF02452 Phobius swissprot:CHPB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CHPB_ECOLI PhylomeDB P33647 http://phylomedb.org/?seqid=P33647 ProteinModelPortal P33647 http://www.proteinmodelportal.org/query/uniprot/P33647 PubMed 12972253 http://www.ncbi.nlm.nih.gov/pubmed/12972253 PubMed 16413033 http://www.ncbi.nlm.nih.gov/pubmed/16413033 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21419338 http://www.ncbi.nlm.nih.gov/pubmed/21419338 PubMed 2848015 http://www.ncbi.nlm.nih.gov/pubmed/2848015 PubMed 3525538 http://www.ncbi.nlm.nih.gov/pubmed/3525538 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8083180 http://www.ncbi.nlm.nih.gov/pubmed/8083180 PubMed 8226627 http://www.ncbi.nlm.nih.gov/pubmed/8226627 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418646 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418646 RefSeq WP_000239577 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000239577 STRING 511145.b4225 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4225&targetmode=cogs STRING COG2337 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2337&targetmode=cogs SUPFAM SSF50118 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50118 UniProtKB CHPB_ECOLI http://www.uniprot.org/uniprot/CHPB_ECOLI UniProtKB-AC P33647 http://www.uniprot.org/uniprot/P33647 charge swissprot:CHPB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CHPB_ECOLI eggNOG COG2337 http://eggnogapi.embl.de/nog_data/html/tree/COG2337 eggNOG ENOG4105MZG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105MZG epestfind swissprot:CHPB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CHPB_ECOLI garnier swissprot:CHPB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CHPB_ECOLI helixturnhelix swissprot:CHPB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CHPB_ECOLI hmoment swissprot:CHPB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CHPB_ECOLI iep swissprot:CHPB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CHPB_ECOLI inforesidue swissprot:CHPB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CHPB_ECOLI octanol swissprot:CHPB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CHPB_ECOLI pepcoil swissprot:CHPB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CHPB_ECOLI pepdigest swissprot:CHPB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CHPB_ECOLI pepinfo swissprot:CHPB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CHPB_ECOLI pepnet swissprot:CHPB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CHPB_ECOLI pepstats swissprot:CHPB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CHPB_ECOLI pepwheel swissprot:CHPB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CHPB_ECOLI pepwindow swissprot:CHPB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CHPB_ECOLI sigcleave swissprot:CHPB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CHPB_ECOLI ## Database ID URL or Descriptions # BioGrid 4263316 272 # EcoGene EG11031 trxA # FUNCTION THIO_ECOLI Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0015035 protein disulfide oxidoreductase activity; IDA:EcoCyc. # GO_function GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor; IBA:GO_Central. # GO_process GO:0000103 sulfate assimilation; IBA:GO_Central. # GO_process GO:0006457 protein folding; IBA:GO_Central. # GO_process GO:0006662 glycerol ether metabolic process; IEA:InterPro. # GO_process GO:0016032 viral process; IEA:UniProtKB-KW. # GO_process GO:0034599 cellular response to oxidative stress; IBA:GO_Central. # GO_process GO:0045454 cell redox homeostasis; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006457 protein folding # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0042592 homeostatic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0044403 symbiosis, encompassing mutualism through parasitism # Gene3D 3.40.30.10 -; 1. # INTERACTION THIO_ECOLI O22160 At2g44920 (xeno); NbExp=2; IntAct=EBI-368542, EBI-2895776; Q9SCY2 FKBP13 (xeno); NbExp=2; IntAct=EBI-368542, EBI-2895757; Q9LXX5 PPD6 (xeno); NbExp=2; IntAct=EBI-368542, EBI-2895738; Q9LU86 PRXQ (xeno); NbExp=2; IntAct=EBI-368542, EBI-540311; P23321 PSBO1 (xeno); NbExp=2; IntAct=EBI-368542, EBI-449414; Q9S841 PSBO2 (xeno); NbExp=2; IntAct=EBI-368542, EBI-449424; P81760 TL17 (xeno); NbExp=2; IntAct=EBI-368542, EBI-449573; P82281 TL29 (xeno); NbExp=2; IntAct=EBI-368542, EBI-2895799; P0A9P4 trxB; NbExp=2; IntAct=EBI-368542, EBI-1029826; Q39249 VDE1 (xeno); NbExp=2; IntAct=EBI-368542, EBI-2895666; # IntAct P0AA25 98 # InterPro IPR005746 Thioredoxin # InterPro IPR012336 Thioredoxin-like_fold # InterPro IPR013766 Thioredoxin_domain # InterPro IPR017937 Thioredoxin_CS # KEGG_Brite ko03110 Chaperones and folding catalysts # Organism THIO_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10438 PTHR10438 # PATRIC 32123053 VBIEscCol129921_3896 # PDB 1F6M X-ray; 2.95 A; C/D/G/H=2-109 # PDB 1KEB X-ray; 1.80 A; A/B=2-109 # PDB 1M7T NMR; -; A=32-108 # PDB 1OAZ X-ray; 2.78 A; A/B=2-109 # PDB 1SKR X-ray; 2.40 A; B=2-109 # PDB 1SKS X-ray; 2.30 A; B=2-109 # PDB 1SKW X-ray; 2.30 A; B=2-109 # PDB 1SL0 X-ray; 3.20 A; B/D=2-109 # PDB 1SL1 X-ray; 2.20 A; B=2-109 # PDB 1SL2 X-ray; 2.30 A; B=2-109 # PDB 1SRX X-ray; 2.80 A; A=2-109 # PDB 1T7P X-ray; 2.20 A; B=2-109 # PDB 1T8E X-ray; 2.54 A; B=2-109 # PDB 1THO X-ray; 2.30 A; A=2-109 # PDB 1TK0 X-ray; 2.30 A; B=2-109 # PDB 1TK5 X-ray; 2.20 A; B=2-109 # PDB 1TK8 X-ray; 2.50 A; B=2-109 # PDB 1TKD X-ray; 2.49 A; B=2-109 # PDB 1TXX X-ray; 2.20 A; A=2-109 # PDB 1X9M X-ray; 2.10 A; B=2-109 # PDB 1X9S X-ray; 2.70 A; B=2-109 # PDB 1X9W X-ray; 2.30 A; B=2-109 # PDB 1XOA NMR; -; A=2-109 # PDB 1XOB NMR; -; A=2-109 # PDB 1ZCP X-ray; 2.30 A; A/B/C/D=2-109 # PDB 1ZYQ X-ray; 2.70 A; B=2-109 # PDB 1ZZY X-ray; 2.50 A; A/B=2-109 # PDB 2AJQ X-ray; 2.60 A; B/I=2-109 # PDB 2BTO X-ray; 2.50 A; T=2-109 # PDB 2EIO X-ray; 2.60 A; A/B/C/D=2-109 # PDB 2EIQ X-ray; 1.90 A; A/B=2-109 # PDB 2EIR X-ray; 2.50 A; A/B/C/D=2-109 # PDB 2FCH X-ray; 2.60 A; A/B/C/D/E/F/G=2-109 # PDB 2FD3 X-ray; 2.45 A; A/B=2-109 # PDB 2H6X X-ray; 2.60 A; A/B=2-109 # PDB 2H6Y X-ray; 2.40 A; A/B=2-109 # PDB 2H6Z X-ray; 2.25 A; A/B=2-109 # PDB 2H70 X-ray; 2.70 A; A/B=2-109 # PDB 2H71 X-ray; 2.20 A; A/B=2-109 # PDB 2H72 X-ray; 2.25 A; A/B=2-109 # PDB 2H73 X-ray; 2.45 A; A/B=2-109 # PDB 2H74 X-ray; 2.40 A; A/B=4-109 # PDB 2H75 X-ray; 2.20 A; A/B=2-109 # PDB 2H76 X-ray; 2.25 A; A/B=2-109 # PDB 2O8V X-ray; 3.00 A; B=2-109 # PDB 2TIR X-ray; 2.00 A; A=2-109 # PDB 2TRX X-ray; 1.68 A; A/B=2-109 # PDB 3DYR X-ray; 2.00 A; A/B=2-109 # PDB 4HU7 X-ray; 1.40 A; A/B=2-109 # PDB 4HU9 X-ray; 1.55 A; A=2-109 # PDB 4HUA X-ray; 1.10 A; A=2-109 # PDB 4X43 X-ray; 1.65 A; A/B/C=2-109 # PIR A91519 TXEC # PIRSF PIRSF000077 Thioredoxin # PROSITE PS00194 THIOREDOXIN_1 # PROSITE PS51352 THIOREDOXIN_2 # Pfam PF00085 Thioredoxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName THIO_ECOLI Thioredoxin-1 # RefSeq NP_418228 NC_000913.3 # RefSeq WP_001280776 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA24534.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAA67582.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the thioredoxin family. {ECO 0000305}. # SIMILARITY Contains 1 thioredoxin domain. {ECO:0000255|PROSITE- ProRule PRU00691}. # SUBUNIT Monomer. Interacts with bacteriophage T3 DNA polymerase. {ECO:0000269|PubMed 10947986}. # SUPFAM SSF52833 SSF52833 # TIGRFAMs TIGR01068 thioredoxin # eggNOG COG0526 LUCA BLAST swissprot:THIO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:THIO_ECOLI BioCyc ECOL316407:JW5856-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5856-MONOMER BioCyc EcoCyc:RED-THIOREDOXIN-MONOMER http://biocyc.org/getid?id=EcoCyc:RED-THIOREDOXIN-MONOMER BioCyc MetaCyc:RED-THIOREDOXIN-MONOMER http://biocyc.org/getid?id=MetaCyc:RED-THIOREDOXIN-MONOMER COG COG0526 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0526 DIP DIP-31856N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31856N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1007/BF01116889 http://dx.doi.org/10.1007/BF01116889 DOI 10.1016/0022-2836(74)90262-9 http://dx.doi.org/10.1016/0022-2836(74)90262-9 DOI 10.1016/0022-2836(90)90313-B http://dx.doi.org/10.1016/0022-2836(90)90313-B DOI 10.1016/0378-1119(84)90015-5 http://dx.doi.org/10.1016/0378-1119(84)90015-5 DOI 10.1016/S0969-2126(94)00086-7 http://dx.doi.org/10.1016/S0969-2126(94)00086-7 DOI 10.1021/bi00070a017 http://dx.doi.org/10.1021/bi00070a017 DOI 10.1021/bi00469a016 http://dx.doi.org/10.1021/bi00469a016 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.72.6.2305 http://dx.doi.org/10.1073/pnas.72.6.2305 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1107/S0907444999008756 http://dx.doi.org/10.1107/S0907444999008756 DOI 10.1111/j.1432-1033.1968.tb00470.x http://dx.doi.org/10.1111/j.1432-1033.1968.tb00470.x DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1126/science.289.5482.1190 http://dx.doi.org/10.1126/science.289.5482.1190 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K02845 http://www.ebi.ac.uk/ena/data/view/K02845 EMBL M10424 http://www.ebi.ac.uk/ena/data/view/M10424 EMBL M12779 http://www.ebi.ac.uk/ena/data/view/M12779 EMBL M26133 http://www.ebi.ac.uk/ena/data/view/M26133 EMBL M54881 http://www.ebi.ac.uk/ena/data/view/M54881 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1024 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1024 EcoGene EG11031 http://www.ecogene.org/geneInfo.php?eg_id=EG11031 EnsemblBacteria AAC76786 http://www.ensemblgenomes.org/id/AAC76786 EnsemblBacteria AAC76786 http://www.ensemblgenomes.org/id/AAC76786 EnsemblBacteria BAE77517 http://www.ensemblgenomes.org/id/BAE77517 EnsemblBacteria BAE77517 http://www.ensemblgenomes.org/id/BAE77517 EnsemblBacteria BAE77517 http://www.ensemblgenomes.org/id/BAE77517 EnsemblBacteria b3781 http://www.ensemblgenomes.org/id/b3781 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0015035 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015035 GO_function GO:0016671 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016671 GO_process GO:0000103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000103 GO_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GO_process GO:0006662 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006662 GO_process GO:0016032 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016032 GO_process GO:0034599 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034599 GO_process GO:0045454 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045454 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0044403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403 Gene3D 3.40.30.10 http://www.cathdb.info/version/latest/superfamily/3.40.30.10 GeneID 23335415 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23335415 GeneID 948289 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948289 HOGENOM HOG000292977 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000292977&db=HOGENOM6 InParanoid P0AA25 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AA25 IntAct P0AA25 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AA25* InterPro IPR005746 http://www.ebi.ac.uk/interpro/entry/IPR005746 InterPro IPR012336 http://www.ebi.ac.uk/interpro/entry/IPR012336 InterPro IPR013766 http://www.ebi.ac.uk/interpro/entry/IPR013766 InterPro IPR017937 http://www.ebi.ac.uk/interpro/entry/IPR017937 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW5856 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5856 KEGG_Gene eco:b3781 http://www.genome.jp/dbget-bin/www_bget?eco:b3781 KEGG_Orthology KO:K03671 http://www.genome.jp/dbget-bin/www_bget?KO:K03671 MINT MINT-1530752 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1530752 OMA MSEHIHY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MSEHIHY PANTHER PTHR10438 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10438 PDB 1F6M http://www.ebi.ac.uk/pdbe-srv/view/entry/1F6M PDB 1KEB http://www.ebi.ac.uk/pdbe-srv/view/entry/1KEB PDB 1M7T http://www.ebi.ac.uk/pdbe-srv/view/entry/1M7T PDB 1OAZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1OAZ PDB 1SKR http://www.ebi.ac.uk/pdbe-srv/view/entry/1SKR PDB 1SKS http://www.ebi.ac.uk/pdbe-srv/view/entry/1SKS PDB 1SKW http://www.ebi.ac.uk/pdbe-srv/view/entry/1SKW PDB 1SL0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1SL0 PDB 1SL1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1SL1 PDB 1SL2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1SL2 PDB 1SRX http://www.ebi.ac.uk/pdbe-srv/view/entry/1SRX PDB 1T7P http://www.ebi.ac.uk/pdbe-srv/view/entry/1T7P PDB 1T8E http://www.ebi.ac.uk/pdbe-srv/view/entry/1T8E PDB 1THO http://www.ebi.ac.uk/pdbe-srv/view/entry/1THO PDB 1TK0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1TK0 PDB 1TK5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1TK5 PDB 1TK8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1TK8 PDB 1TKD http://www.ebi.ac.uk/pdbe-srv/view/entry/1TKD PDB 1TXX http://www.ebi.ac.uk/pdbe-srv/view/entry/1TXX PDB 1X9M http://www.ebi.ac.uk/pdbe-srv/view/entry/1X9M PDB 1X9S http://www.ebi.ac.uk/pdbe-srv/view/entry/1X9S PDB 1X9W http://www.ebi.ac.uk/pdbe-srv/view/entry/1X9W PDB 1XOA http://www.ebi.ac.uk/pdbe-srv/view/entry/1XOA PDB 1XOB http://www.ebi.ac.uk/pdbe-srv/view/entry/1XOB PDB 1ZCP http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZCP PDB 1ZYQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZYQ PDB 1ZZY http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZZY PDB 2AJQ http://www.ebi.ac.uk/pdbe-srv/view/entry/2AJQ PDB 2BTO http://www.ebi.ac.uk/pdbe-srv/view/entry/2BTO PDB 2EIO http://www.ebi.ac.uk/pdbe-srv/view/entry/2EIO PDB 2EIQ http://www.ebi.ac.uk/pdbe-srv/view/entry/2EIQ PDB 2EIR http://www.ebi.ac.uk/pdbe-srv/view/entry/2EIR PDB 2FCH http://www.ebi.ac.uk/pdbe-srv/view/entry/2FCH PDB 2FD3 http://www.ebi.ac.uk/pdbe-srv/view/entry/2FD3 PDB 2H6X http://www.ebi.ac.uk/pdbe-srv/view/entry/2H6X PDB 2H6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/2H6Y PDB 2H6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/2H6Z PDB 2H70 http://www.ebi.ac.uk/pdbe-srv/view/entry/2H70 PDB 2H71 http://www.ebi.ac.uk/pdbe-srv/view/entry/2H71 PDB 2H72 http://www.ebi.ac.uk/pdbe-srv/view/entry/2H72 PDB 2H73 http://www.ebi.ac.uk/pdbe-srv/view/entry/2H73 PDB 2H74 http://www.ebi.ac.uk/pdbe-srv/view/entry/2H74 PDB 2H75 http://www.ebi.ac.uk/pdbe-srv/view/entry/2H75 PDB 2H76 http://www.ebi.ac.uk/pdbe-srv/view/entry/2H76 PDB 2O8V http://www.ebi.ac.uk/pdbe-srv/view/entry/2O8V PDB 2TIR http://www.ebi.ac.uk/pdbe-srv/view/entry/2TIR PDB 2TRX http://www.ebi.ac.uk/pdbe-srv/view/entry/2TRX PDB 3DYR http://www.ebi.ac.uk/pdbe-srv/view/entry/3DYR PDB 4HU7 http://www.ebi.ac.uk/pdbe-srv/view/entry/4HU7 PDB 4HU9 http://www.ebi.ac.uk/pdbe-srv/view/entry/4HU9 PDB 4HUA http://www.ebi.ac.uk/pdbe-srv/view/entry/4HUA PDB 4X43 http://www.ebi.ac.uk/pdbe-srv/view/entry/4X43 PDBsum 1F6M http://www.ebi.ac.uk/pdbsum/1F6M PDBsum 1KEB http://www.ebi.ac.uk/pdbsum/1KEB PDBsum 1M7T http://www.ebi.ac.uk/pdbsum/1M7T PDBsum 1OAZ http://www.ebi.ac.uk/pdbsum/1OAZ PDBsum 1SKR http://www.ebi.ac.uk/pdbsum/1SKR PDBsum 1SKS http://www.ebi.ac.uk/pdbsum/1SKS PDBsum 1SKW http://www.ebi.ac.uk/pdbsum/1SKW PDBsum 1SL0 http://www.ebi.ac.uk/pdbsum/1SL0 PDBsum 1SL1 http://www.ebi.ac.uk/pdbsum/1SL1 PDBsum 1SL2 http://www.ebi.ac.uk/pdbsum/1SL2 PDBsum 1SRX http://www.ebi.ac.uk/pdbsum/1SRX PDBsum 1T7P http://www.ebi.ac.uk/pdbsum/1T7P PDBsum 1T8E http://www.ebi.ac.uk/pdbsum/1T8E PDBsum 1THO http://www.ebi.ac.uk/pdbsum/1THO PDBsum 1TK0 http://www.ebi.ac.uk/pdbsum/1TK0 PDBsum 1TK5 http://www.ebi.ac.uk/pdbsum/1TK5 PDBsum 1TK8 http://www.ebi.ac.uk/pdbsum/1TK8 PDBsum 1TKD http://www.ebi.ac.uk/pdbsum/1TKD PDBsum 1TXX http://www.ebi.ac.uk/pdbsum/1TXX PDBsum 1X9M http://www.ebi.ac.uk/pdbsum/1X9M PDBsum 1X9S http://www.ebi.ac.uk/pdbsum/1X9S PDBsum 1X9W http://www.ebi.ac.uk/pdbsum/1X9W PDBsum 1XOA http://www.ebi.ac.uk/pdbsum/1XOA PDBsum 1XOB http://www.ebi.ac.uk/pdbsum/1XOB PDBsum 1ZCP http://www.ebi.ac.uk/pdbsum/1ZCP PDBsum 1ZYQ http://www.ebi.ac.uk/pdbsum/1ZYQ PDBsum 1ZZY http://www.ebi.ac.uk/pdbsum/1ZZY PDBsum 2AJQ http://www.ebi.ac.uk/pdbsum/2AJQ PDBsum 2BTO http://www.ebi.ac.uk/pdbsum/2BTO PDBsum 2EIO http://www.ebi.ac.uk/pdbsum/2EIO PDBsum 2EIQ http://www.ebi.ac.uk/pdbsum/2EIQ PDBsum 2EIR http://www.ebi.ac.uk/pdbsum/2EIR PDBsum 2FCH http://www.ebi.ac.uk/pdbsum/2FCH PDBsum 2FD3 http://www.ebi.ac.uk/pdbsum/2FD3 PDBsum 2H6X http://www.ebi.ac.uk/pdbsum/2H6X PDBsum 2H6Y http://www.ebi.ac.uk/pdbsum/2H6Y PDBsum 2H6Z http://www.ebi.ac.uk/pdbsum/2H6Z PDBsum 2H70 http://www.ebi.ac.uk/pdbsum/2H70 PDBsum 2H71 http://www.ebi.ac.uk/pdbsum/2H71 PDBsum 2H72 http://www.ebi.ac.uk/pdbsum/2H72 PDBsum 2H73 http://www.ebi.ac.uk/pdbsum/2H73 PDBsum 2H74 http://www.ebi.ac.uk/pdbsum/2H74 PDBsum 2H75 http://www.ebi.ac.uk/pdbsum/2H75 PDBsum 2H76 http://www.ebi.ac.uk/pdbsum/2H76 PDBsum 2O8V http://www.ebi.ac.uk/pdbsum/2O8V PDBsum 2TIR http://www.ebi.ac.uk/pdbsum/2TIR PDBsum 2TRX http://www.ebi.ac.uk/pdbsum/2TRX PDBsum 3DYR http://www.ebi.ac.uk/pdbsum/3DYR PDBsum 4HU7 http://www.ebi.ac.uk/pdbsum/4HU7 PDBsum 4HU9 http://www.ebi.ac.uk/pdbsum/4HU9 PDBsum 4HUA http://www.ebi.ac.uk/pdbsum/4HUA PDBsum 4X43 http://www.ebi.ac.uk/pdbsum/4X43 PROSITE PS00194 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00194 PROSITE PS51352 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51352 PSORT swissprot:THIO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:THIO_ECOLI PSORT-B swissprot:THIO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:THIO_ECOLI PSORT2 swissprot:THIO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:THIO_ECOLI Pfam PF00085 http://pfam.xfam.org/family/PF00085 Phobius swissprot:THIO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:THIO_ECOLI PhylomeDB P0AA25 http://phylomedb.org/?seqid=P0AA25 ProteinModelPortal P0AA25 http://www.proteinmodelportal.org/query/uniprot/P0AA25 PubMed 10489448 http://www.ncbi.nlm.nih.gov/pubmed/10489448 PubMed 1094461 http://www.ncbi.nlm.nih.gov/pubmed/1094461 PubMed 10947986 http://www.ncbi.nlm.nih.gov/pubmed/10947986 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 2181145 http://www.ncbi.nlm.nih.gov/pubmed/2181145 PubMed 2193685 http://www.ncbi.nlm.nih.gov/pubmed/2193685 PubMed 3891733 http://www.ncbi.nlm.nih.gov/pubmed/3891733 PubMed 4616096 http://www.ncbi.nlm.nih.gov/pubmed/4616096 PubMed 4883076 http://www.ncbi.nlm.nih.gov/pubmed/4883076 PubMed 6098320 http://www.ncbi.nlm.nih.gov/pubmed/6098320 PubMed 6099324 http://www.ncbi.nlm.nih.gov/pubmed/6099324 PubMed 7812718 http://www.ncbi.nlm.nih.gov/pubmed/7812718 PubMed 8098620 http://www.ncbi.nlm.nih.gov/pubmed/8098620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_418228 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418228 RefSeq WP_001280776 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001280776 SMR P0AA25 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AA25 STRING 511145.b3781 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3781&targetmode=cogs STRING COG0526 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0526&targetmode=cogs SUPFAM SSF52833 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52833 SWISS-2DPAGE P0AA25 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AA25 TIGRFAMs TIGR01068 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01068 UniProtKB THIO_ECOLI http://www.uniprot.org/uniprot/THIO_ECOLI UniProtKB-AC P0AA25 http://www.uniprot.org/uniprot/P0AA25 charge swissprot:THIO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:THIO_ECOLI eggNOG COG0526 http://eggnogapi.embl.de/nog_data/html/tree/COG0526 epestfind swissprot:THIO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:THIO_ECOLI garnier swissprot:THIO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:THIO_ECOLI helixturnhelix swissprot:THIO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:THIO_ECOLI hmoment swissprot:THIO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:THIO_ECOLI iep swissprot:THIO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:THIO_ECOLI inforesidue swissprot:THIO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:THIO_ECOLI octanol swissprot:THIO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:THIO_ECOLI pepcoil swissprot:THIO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:THIO_ECOLI pepdigest swissprot:THIO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:THIO_ECOLI pepinfo swissprot:THIO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:THIO_ECOLI pepnet swissprot:THIO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:THIO_ECOLI pepstats swissprot:THIO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:THIO_ECOLI pepwheel swissprot:THIO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:THIO_ECOLI pepwindow swissprot:THIO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:THIO_ECOLI sigcleave swissprot:THIO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:THIO_ECOLI ## Database ID URL or Descriptions # BioGrid 4259874 9 # EcoGene EG13626 ylbF # IntAct P0AAS5 7 # InterPro IPR021530 DUF2877 # Organism YLBF_ECOLI Escherichia coli (strain K12) # PATRIC 32116200 VBIEscCol129921_0541 # PIR G64783 G64783 # Pfam PF11392 DUF2877 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YLBF_ECOLI Uncharacterized protein YlbF # RefSeq NP_415053 NC_000913.3 # RefSeq WP_000152519 NZ_LN832404.1 # eggNOG ENOG4105G5A Bacteria # eggNOG ENOG4111STC LUCA BLAST swissprot:YLBF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YLBF_ECOLI BioCyc ECOL316407:JW0509-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0509-MONOMER BioCyc EcoCyc:G6289-MONOMER http://biocyc.org/getid?id=EcoCyc:G6289-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EchoBASE EB3391 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3391 EcoGene EG13626 http://www.ecogene.org/geneInfo.php?eg_id=EG13626 EnsemblBacteria AAC73622 http://www.ensemblgenomes.org/id/AAC73622 EnsemblBacteria AAC73622 http://www.ensemblgenomes.org/id/AAC73622 EnsemblBacteria BAE76297 http://www.ensemblgenomes.org/id/BAE76297 EnsemblBacteria BAE76297 http://www.ensemblgenomes.org/id/BAE76297 EnsemblBacteria BAE76297 http://www.ensemblgenomes.org/id/BAE76297 EnsemblBacteria b0520 http://www.ensemblgenomes.org/id/b0520 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945195 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945195 HOGENOM HOG000117734 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117734&db=HOGENOM6 IntAct P0AAS5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAS5* InterPro IPR021530 http://www.ebi.ac.uk/interpro/entry/IPR021530 KEGG_Gene ecj:JW0509 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0509 KEGG_Gene eco:b0520 http://www.genome.jp/dbget-bin/www_bget?eco:b0520 OMA RPFFAFS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RPFFAFS PSORT swissprot:YLBF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YLBF_ECOLI PSORT-B swissprot:YLBF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YLBF_ECOLI PSORT2 swissprot:YLBF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YLBF_ECOLI Pfam PF11392 http://pfam.xfam.org/family/PF11392 Phobius swissprot:YLBF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YLBF_ECOLI ProteinModelPortal P0AAS5 http://www.proteinmodelportal.org/query/uniprot/P0AAS5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415053 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415053 RefSeq WP_000152519 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000152519 STRING 511145.b0520 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0520&targetmode=cogs UniProtKB YLBF_ECOLI http://www.uniprot.org/uniprot/YLBF_ECOLI UniProtKB-AC P0AAS5 http://www.uniprot.org/uniprot/P0AAS5 charge swissprot:YLBF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YLBF_ECOLI eggNOG ENOG4105G5A http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105G5A eggNOG ENOG4111STC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111STC epestfind swissprot:YLBF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YLBF_ECOLI garnier swissprot:YLBF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YLBF_ECOLI helixturnhelix swissprot:YLBF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YLBF_ECOLI hmoment swissprot:YLBF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YLBF_ECOLI iep swissprot:YLBF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YLBF_ECOLI inforesidue swissprot:YLBF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YLBF_ECOLI octanol swissprot:YLBF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YLBF_ECOLI pepcoil swissprot:YLBF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YLBF_ECOLI pepdigest swissprot:YLBF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YLBF_ECOLI pepinfo swissprot:YLBF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YLBF_ECOLI pepnet swissprot:YLBF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YLBF_ECOLI pepstats swissprot:YLBF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YLBF_ECOLI pepwheel swissprot:YLBF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YLBF_ECOLI pepwindow swissprot:YLBF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YLBF_ECOLI sigcleave swissprot:YLBF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YLBF_ECOLI ## Database ID URL or Descriptions # AltName ATP synthase F1 sector subunit alpha {ECO:0000255|HAMAP-Rule MF_01346} # AltName F-ATPase subunit alpha {ECO:0000255|HAMAP-Rule MF_01346} # CATALYTIC ACTIVITY ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out). {ECO:0000255|HAMAP-Rule MF_01346}. # CDD cd01132 F1_ATPase_alpha # EcoGene EG10098 atpA # FUNCTION ATPA_ECOLI Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_component GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1); IMP:EcoliWiki. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0046933 proton-transporting ATP synthase activity, rotational mechanism; IEA:UniProtKB-HAMAP. # GO_process GO:0015986 ATP synthesis coupled proton transport; IMP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0055085 transmembrane transport # Gene3D 2.40.30.20 -; 1. # Gene3D 3.40.50.300 -; 1. # HAMAP MF_01346 ATP_synth_alpha_bact # INTERACTION ATPA_ECOLI P0ABB4 atpD; NbExp=10; IntAct=EBI-368707, EBI-368783; # IntAct P0ABB0 28 # InterPro IPR000194 ATPase_F1/V1/A1_a/bsu_nucl-bd # InterPro IPR000793 ATP_synth_asu_C # InterPro IPR004100 ATPase_F1/V1/A1_a/bsu_N # InterPro IPR005294 ATP_synth_F1_asu # InterPro IPR020003 ATPase_a/bsu_AS # InterPro IPR023366 ATP_synth_asu-like # InterPro IPR027417 P-loop_NTPase # InterPro IPR033732 ATP_synth_F1_a # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko00194 Photosynthesis proteins # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00190 Oxidative phosphorylation # KEGG_Pathway ko00195 Photosynthesis # Organism ATPA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR15184:SF3 PTHR15184:SF3 # PATRIC 32122965 VBIEscCol129921_3858 # PDB 1D8S X-ray; 4.40 A; A/B/C=1-513 # PDB 3OAA X-ray; 3.26 A; A/B/C/I/J/K/Q/R/S/Y/Z/a=1-513 # PIR G65176 PWECA # PROSITE PS00152 ATPASE_ALPHA_BETA # Pfam PF00006 ATP-synt_ab # Pfam PF00306 ATP-synt_ab_C # Pfam PF02874 ATP-synt_ab_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ATP synthase subunit alpha {ECO:0000255|HAMAP-Rule MF_01346} # RefSeq NP_418190 NC_000913.3 # RefSeq WP_001176745 NZ_LN832404.1 # SIMILARITY Belongs to the ATPase alpha/beta chains family. {ECO:0000255|HAMAP-Rule MF_01346}. # SUBCELLULAR LOCATION ATPA_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01346, ECO 0000269|PubMed 16079137}; Peripheral membrane protein {ECO 0000255|HAMAP-Rule MF_01346, ECO 0000269|PubMed 16079137}. # SUBUNIT ATPA_ECOLI F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains. {ECO 0000255|HAMAP- Rule MF_01346}. # SUPFAM SSF50615 SSF50615 # SUPFAM SSF52540 SSF52540 # TCDB 3.A.2.1 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily # TIGRFAMs TIGR00962 atpA # eggNOG COG0056 LUCA # eggNOG ENOG4105CDG Bacteria BLAST swissprot:ATPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ATPA_ECOLI BioCyc ECOL316407:JW3712-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3712-MONOMER BioCyc EcoCyc:ATPA-MONOMER http://biocyc.org/getid?id=EcoCyc:ATPA-MONOMER BioCyc MetaCyc:ATPA-MONOMER http://biocyc.org/getid?id=MetaCyc:ATPA-MONOMER COG COG0056 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0056 DIP DIP-31845N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31845N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1007/BF00271191 http://dx.doi.org/10.1007/BF00271191 DOI 10.1016/0006-291X(81)90494-0 http://dx.doi.org/10.1016/0006-291X(81)90494-0 DOI 10.1016/0014-5793(86)80310-6 http://dx.doi.org/10.1016/0014-5793(86)80310-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2240799 http://dx.doi.org/10.1042/bj2240799 DOI 10.1073/pnas.96.24.13697 http://dx.doi.org/10.1073/pnas.96.24.13697 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1093/nar/9.9.2187 http://dx.doi.org/10.1093/nar/9.9.2187 DOI 10.1111/j.1749-6632.1982.tb25731.x http://dx.doi.org/10.1111/j.1749-6632.1982.tb25731.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.3.14 {ECO:0000255|HAMAP-Rule:MF_01346} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.14 {ECO:0000255|HAMAP-Rule:MF_01346} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01594 http://www.ebi.ac.uk/ena/data/view/J01594 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M12212 http://www.ebi.ac.uk/ena/data/view/M12212 EMBL M25464 http://www.ebi.ac.uk/ena/data/view/M25464 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00265 http://www.ebi.ac.uk/ena/data/view/V00265 EMBL V00266 http://www.ebi.ac.uk/ena/data/view/V00266 EMBL V00312 http://www.ebi.ac.uk/ena/data/view/V00312 EMBL X01631 http://www.ebi.ac.uk/ena/data/view/X01631 ENZYME 3.6.3.14 {ECO:0000255|HAMAP-Rule:MF_01346} http://enzyme.expasy.org/EC/3.6.3.14 {ECO:0000255|HAMAP-Rule:MF_01346} EchoBASE EB0096 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0096 EcoGene EG10098 http://www.ecogene.org/geneInfo.php?eg_id=EG10098 EnsemblBacteria AAC76757 http://www.ensemblgenomes.org/id/AAC76757 EnsemblBacteria AAC76757 http://www.ensemblgenomes.org/id/AAC76757 EnsemblBacteria BAE77554 http://www.ensemblgenomes.org/id/BAE77554 EnsemblBacteria BAE77554 http://www.ensemblgenomes.org/id/BAE77554 EnsemblBacteria BAE77554 http://www.ensemblgenomes.org/id/BAE77554 EnsemblBacteria b3734 http://www.ensemblgenomes.org/id/b3734 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0045261 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045261 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0046933 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046933 GO_process GO:0015986 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015986 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 2.40.30.20 http://www.cathdb.info/version/latest/superfamily/2.40.30.20 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948242 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948242 HAMAP MF_01346 http://hamap.expasy.org/unirule/MF_01346 HOGENOM HOG000130111 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000130111&db=HOGENOM6 InParanoid P0ABB0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABB0 IntAct P0ABB0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABB0* IntEnz 3.6.3.14 {ECO:0000255|HAMAP-Rule:MF_01346} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.14 {ECO:0000255|HAMAP-Rule:MF_01346} InterPro IPR000194 http://www.ebi.ac.uk/interpro/entry/IPR000194 InterPro IPR000793 http://www.ebi.ac.uk/interpro/entry/IPR000793 InterPro IPR004100 http://www.ebi.ac.uk/interpro/entry/IPR004100 InterPro IPR005294 http://www.ebi.ac.uk/interpro/entry/IPR005294 InterPro IPR020003 http://www.ebi.ac.uk/interpro/entry/IPR020003 InterPro IPR023366 http://www.ebi.ac.uk/interpro/entry/IPR023366 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR033732 http://www.ebi.ac.uk/interpro/entry/IPR033732 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko00194 http://www.genome.jp/dbget-bin/www_bget?ko00194 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3712 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3712 KEGG_Gene eco:b3734 http://www.genome.jp/dbget-bin/www_bget?eco:b3734 KEGG_Orthology KO:K02111 http://www.genome.jp/dbget-bin/www_bget?KO:K02111 KEGG_Pathway ko00190 http://www.genome.jp/kegg-bin/show_pathway?ko00190 KEGG_Pathway ko00195 http://www.genome.jp/kegg-bin/show_pathway?ko00195 MINT MINT-1251537 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1251537 OMA PVFCIYV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PVFCIYV PANTHER PTHR15184:SF3 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15184:SF3 PDB 1D8S http://www.ebi.ac.uk/pdbe-srv/view/entry/1D8S PDB 3OAA http://www.ebi.ac.uk/pdbe-srv/view/entry/3OAA PDBsum 1D8S http://www.ebi.ac.uk/pdbsum/1D8S PDBsum 3OAA http://www.ebi.ac.uk/pdbsum/3OAA PROSITE PS00152 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00152 PSORT swissprot:ATPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ATPA_ECOLI PSORT-B swissprot:ATPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ATPA_ECOLI PSORT2 swissprot:ATPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ATPA_ECOLI Pfam PF00006 http://pfam.xfam.org/family/PF00006 Pfam PF00306 http://pfam.xfam.org/family/PF00306 Pfam PF02874 http://pfam.xfam.org/family/PF02874 Phobius swissprot:ATPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ATPA_ECOLI PhylomeDB P0ABB0 http://phylomedb.org/?seqid=P0ABB0 ProteinModelPortal P0ABB0 http://www.proteinmodelportal.org/query/uniprot/P0ABB0 PubMed 10570135 http://www.ncbi.nlm.nih.gov/pubmed/10570135 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2868922 http://www.ncbi.nlm.nih.gov/pubmed/2868922 PubMed 2903146 http://www.ncbi.nlm.nih.gov/pubmed/2903146 PubMed 6272228 http://www.ncbi.nlm.nih.gov/pubmed/6272228 PubMed 6277310 http://www.ncbi.nlm.nih.gov/pubmed/6277310 PubMed 6278247 http://www.ncbi.nlm.nih.gov/pubmed/6278247 PubMed 6301339 http://www.ncbi.nlm.nih.gov/pubmed/6301339 PubMed 6395859 http://www.ncbi.nlm.nih.gov/pubmed/6395859 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_418190 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418190 RefSeq WP_001176745 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001176745 SMR P0ABB0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABB0 STRING 511145.b3734 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3734&targetmode=cogs STRING COG0056 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0056&targetmode=cogs SUPFAM SSF50615 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50615 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SWISS-2DPAGE P0ABB0 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0ABB0 TCDB 3.A.2.1 http://www.tcdb.org/search/result.php?tc=3.A.2.1 TIGRFAMs TIGR00962 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00962 UniProtKB ATPA_ECOLI http://www.uniprot.org/uniprot/ATPA_ECOLI UniProtKB-AC P0ABB0 http://www.uniprot.org/uniprot/P0ABB0 charge swissprot:ATPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ATPA_ECOLI eggNOG COG0056 http://eggnogapi.embl.de/nog_data/html/tree/COG0056 eggNOG ENOG4105CDG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CDG epestfind swissprot:ATPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ATPA_ECOLI garnier swissprot:ATPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ATPA_ECOLI helixturnhelix swissprot:ATPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ATPA_ECOLI hmoment swissprot:ATPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ATPA_ECOLI iep swissprot:ATPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ATPA_ECOLI inforesidue swissprot:ATPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ATPA_ECOLI octanol swissprot:ATPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ATPA_ECOLI pepcoil swissprot:ATPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ATPA_ECOLI pepdigest swissprot:ATPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ATPA_ECOLI pepinfo swissprot:ATPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ATPA_ECOLI pepnet swissprot:ATPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ATPA_ECOLI pepstats swissprot:ATPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ATPA_ECOLI pepwheel swissprot:ATPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ATPA_ECOLI pepwindow swissprot:ATPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ATPA_ECOLI sigcleave swissprot:ATPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ATPA_ECOLI ## Database ID URL or Descriptions # BRENDA 1.2.4 2026 # BioGrid 4261303 14 # CATALYTIC ACTIVITY ODP1_ECOLI Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO(2). # COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI 18420; # COFACTOR Name=thiamine diphosphate; Xref=ChEBI:CHEBI 58937; # EcoGene EG10024 aceE # FUNCTION ODP1_ECOLI Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0004738 pyruvate dehydrogenase activity; IGI:EcoliWiki. # GO_function GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity; IEA:UniProtKB-EC. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006096 glycolytic process; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.920 -; 1. # Gene3D 3.40.50.970 -; 2. # INTERACTION ODP1_ECOLI Self; NbExp=2; IntAct=EBI-542683, EBI-542683; P0A6F5 groL; NbExp=2; IntAct=EBI-542683, EBI-543750; P0AB83 nth; NbExp=2; IntAct=EBI-542683, EBI-555213; P0A9U1 ybhF; NbExp=2; IntAct=EBI-542683, EBI-547696; P0A8L7 yciU; NbExp=2; IntAct=EBI-542683, EBI-544511; # IntAct P0AFG8 104 # InterPro IPR004660 2-oxoA_DH_E1 # InterPro IPR005474 Transketolase_N # InterPro IPR009014 Transketo_C/PFOR_II # InterPro IPR029061 THDP-binding # InterPro IPR033247 Transketolase_fam # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00010 Glycolysis / Gluconeogenesis # KEGG_Pathway ko00020 Citrate cycle (TCA cycle) # KEGG_Pathway ko00620 Pyruvate metabolism # KEGG_Pathway ko00650 Butanoate metabolism # Organism ODP1_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11624 PTHR11624; 5 # PATRIC 32115329 VBIEscCol129921_0116 # PDB 1L8A X-ray; 1.85 A; A/B=2-887 # PDB 1RP7 X-ray; 2.09 A; A/B=2-887 # PDB 2G25 X-ray; 2.10 A; A/B=2-887 # PDB 2G28 X-ray; 1.85 A; A/B=2-887 # PDB 2G67 X-ray; 2.32 A; A/B=2-887 # PDB 2IEA X-ray; 1.85 A; A/B=2-887 # PDB 2QTA X-ray; 1.85 A; A/B=2-887 # PDB 2QTC X-ray; 1.77 A; A/B=2-887 # PIR B64734 DEECPV # PIRSF PIRSF000156 Pyruvate_dh_E1 # Pfam PF00456 Transketolase_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ODP1_ECOLI Pyruvate dehydrogenase E1 component # RefSeq NP_414656 NC_000913.3 # RefSeq WP_000003820 NZ_LN832404.1 # SUBUNIT ODP1_ECOLI Homodimer. Part of the PDH complex, consisting of multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). # SUPFAM SSF52518 SSF52518; 2 # SUPFAM SSF52922 SSF52922 # TIGRFAMs TIGR00759 aceE # eggNOG COG2609 LUCA # eggNOG ENOG4105DAQ Bacteria BLAST swissprot:ODP1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ODP1_ECOLI BioCyc ECOL316407:JW0110-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0110-MONOMER BioCyc EcoCyc:E1P-MONOMER http://biocyc.org/getid?id=EcoCyc:E1P-MONOMER BioCyc MetaCyc:E1P-MONOMER http://biocyc.org/getid?id=MetaCyc:E1P-MONOMER COG COG2609 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2609 DIP DIP-9039N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9039N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1016/0014-5793(93)81605-Y http://dx.doi.org/10.1016/0014-5793(93)81605-Y DOI 10.1021/bi0118557 http://dx.doi.org/10.1021/bi0118557 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1111/j.1432-1033.1983.tb07441.x http://dx.doi.org/10.1111/j.1432-1033.1983.tb07441.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DisProt DP00427 http://www.disprot.org/protein.php?id=DP00427 EC_number EC:1.2.4.1 http://www.genome.jp/dbget-bin/www_bget?EC:1.2.4.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL S67363 http://www.ebi.ac.uk/ena/data/view/S67363 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V01498 http://www.ebi.ac.uk/ena/data/view/V01498 ENZYME 1.2.4.1 http://enzyme.expasy.org/EC/1.2.4.1 EchoBASE EB0023 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0023 EcoGene EG10024 http://www.ecogene.org/geneInfo.php?eg_id=EG10024 EnsemblBacteria AAC73225 http://www.ensemblgenomes.org/id/AAC73225 EnsemblBacteria AAC73225 http://www.ensemblgenomes.org/id/AAC73225 EnsemblBacteria BAB96684 http://www.ensemblgenomes.org/id/BAB96684 EnsemblBacteria BAB96684 http://www.ensemblgenomes.org/id/BAB96684 EnsemblBacteria BAB96684 http://www.ensemblgenomes.org/id/BAB96684 EnsemblBacteria b0114 http://www.ensemblgenomes.org/id/b0114 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0004738 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004738 GO_function GO:0004739 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004739 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006096 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006096 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.920 http://www.cathdb.info/version/latest/superfamily/3.40.50.920 Gene3D 3.40.50.970 http://www.cathdb.info/version/latest/superfamily/3.40.50.970 GeneID 944834 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944834 HOGENOM HOG000115215 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000115215&db=HOGENOM6 InParanoid P0AFG8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFG8 IntAct P0AFG8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFG8* IntEnz 1.2.4.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.2.4.1 InterPro IPR004660 http://www.ebi.ac.uk/interpro/entry/IPR004660 InterPro IPR005474 http://www.ebi.ac.uk/interpro/entry/IPR005474 InterPro IPR009014 http://www.ebi.ac.uk/interpro/entry/IPR009014 InterPro IPR029061 http://www.ebi.ac.uk/interpro/entry/IPR029061 InterPro IPR033247 http://www.ebi.ac.uk/interpro/entry/IPR033247 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0110 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0110 KEGG_Gene eco:b0114 http://www.genome.jp/dbget-bin/www_bget?eco:b0114 KEGG_Orthology KO:K00163 http://www.genome.jp/dbget-bin/www_bget?KO:K00163 KEGG_Pathway ko00010 http://www.genome.jp/kegg-bin/show_pathway?ko00010 KEGG_Pathway ko00020 http://www.genome.jp/kegg-bin/show_pathway?ko00020 KEGG_Pathway ko00620 http://www.genome.jp/kegg-bin/show_pathway?ko00620 KEGG_Pathway ko00650 http://www.genome.jp/kegg-bin/show_pathway?ko00650 KEGG_Reaction rn:R00014 http://www.genome.jp/dbget-bin/www_bget?rn:R00014 KEGG_Reaction rn:R01699 http://www.genome.jp/dbget-bin/www_bget?rn:R01699 KEGG_Reaction rn:R03270 http://www.genome.jp/dbget-bin/www_bget?rn:R03270 MINT MINT-1261483 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1261483 OMA GFVPQRR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GFVPQRR PANTHER PTHR11624 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11624 PDB 1L8A http://www.ebi.ac.uk/pdbe-srv/view/entry/1L8A PDB 1RP7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1RP7 PDB 2G25 http://www.ebi.ac.uk/pdbe-srv/view/entry/2G25 PDB 2G28 http://www.ebi.ac.uk/pdbe-srv/view/entry/2G28 PDB 2G67 http://www.ebi.ac.uk/pdbe-srv/view/entry/2G67 PDB 2IEA http://www.ebi.ac.uk/pdbe-srv/view/entry/2IEA PDB 2QTA http://www.ebi.ac.uk/pdbe-srv/view/entry/2QTA PDB 2QTC http://www.ebi.ac.uk/pdbe-srv/view/entry/2QTC PDBsum 1L8A http://www.ebi.ac.uk/pdbsum/1L8A PDBsum 1RP7 http://www.ebi.ac.uk/pdbsum/1RP7 PDBsum 2G25 http://www.ebi.ac.uk/pdbsum/2G25 PDBsum 2G28 http://www.ebi.ac.uk/pdbsum/2G28 PDBsum 2G67 http://www.ebi.ac.uk/pdbsum/2G67 PDBsum 2IEA http://www.ebi.ac.uk/pdbsum/2IEA PDBsum 2QTA http://www.ebi.ac.uk/pdbsum/2QTA PDBsum 2QTC http://www.ebi.ac.uk/pdbsum/2QTC PSORT swissprot:ODP1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ODP1_ECOLI PSORT-B swissprot:ODP1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ODP1_ECOLI PSORT2 swissprot:ODP1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ODP1_ECOLI Pfam PF00456 http://pfam.xfam.org/family/PF00456 Phobius swissprot:ODP1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ODP1_ECOLI PhylomeDB P0AFG8 http://phylomedb.org/?seqid=P0AFG8 ProteinModelPortal P0AFG8 http://www.proteinmodelportal.org/query/uniprot/P0AFG8 PubMed 11955070 http://www.ncbi.nlm.nih.gov/pubmed/11955070 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 6343085 http://www.ncbi.nlm.nih.gov/pubmed/6343085 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 8262214 http://www.ncbi.nlm.nih.gov/pubmed/8262214 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_414656 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414656 RefSeq WP_000003820 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000003820 SMR P0AFG8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFG8 STRING 511145.b0114 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0114&targetmode=cogs STRING COG2609 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2609&targetmode=cogs SUPFAM SSF52518 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52518 SUPFAM SSF52922 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52922 SWISS-2DPAGE P0AFG8 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AFG8 TIGRFAMs TIGR00759 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00759 UniProtKB ODP1_ECOLI http://www.uniprot.org/uniprot/ODP1_ECOLI UniProtKB-AC P0AFG8 http://www.uniprot.org/uniprot/P0AFG8 charge swissprot:ODP1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ODP1_ECOLI eggNOG COG2609 http://eggnogapi.embl.de/nog_data/html/tree/COG2609 eggNOG ENOG4105DAQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DAQ epestfind swissprot:ODP1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ODP1_ECOLI garnier swissprot:ODP1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ODP1_ECOLI helixturnhelix swissprot:ODP1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ODP1_ECOLI hmoment swissprot:ODP1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ODP1_ECOLI iep swissprot:ODP1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ODP1_ECOLI inforesidue swissprot:ODP1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ODP1_ECOLI octanol swissprot:ODP1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ODP1_ECOLI pepcoil swissprot:ODP1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ODP1_ECOLI pepdigest swissprot:ODP1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ODP1_ECOLI pepinfo swissprot:ODP1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ODP1_ECOLI pepnet swissprot:ODP1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ODP1_ECOLI pepstats swissprot:ODP1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ODP1_ECOLI pepwheel swissprot:ODP1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ODP1_ECOLI pepwindow swissprot:ODP1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ODP1_ECOLI sigcleave swissprot:ODP1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ODP1_ECOLI ## Database ID URL or Descriptions # BioGrid 4260973 10 # EcoGene EG12549 yjhG # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0050401 xylonate dehydratase activity; IMP:EcoCyc. # GO_process GO:0009082 branched-chain amino acid biosynthetic process; IBA:GO_Central. # GO_process GO:0046176 aldonic acid catabolic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # IntAct P39358 4 # InterPro IPR000581 DiOHA_6PGluconate_deHydtase # InterPro IPR015928 Aconitase/3IPM_dehydase_swvl # InterPro IPR017798 Dehydratase_YjhG/YagF # InterPro IPR020558 DiOHA_6PGluconate_deHydtase_CS # Organism YJHG_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21000 PTHR21000 # PATRIC 32124180 VBIEscCol129921_4433 # PIR C65243 C65243 # PROSITE PS00886 ILVD_EDD_1 # PROSITE PS00887 ILVD_EDD_2 # Pfam PF00920 ILVD_EDD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJHG_ECOLI Uncharacterized protein YjhG # RefSeq NP_418717 NC_000913.3 # RefSeq WP_000116326 NZ_LN832404.1 # SIMILARITY Belongs to the IlvD/Edd family. {ECO 0000305}. # SUPFAM SSF52016 SSF52016 # TIGRFAMs TIGR03432 yjhG_yagF # eggNOG COG0129 LUCA # eggNOG ENOG4105C01 Bacteria BLAST swissprot:YJHG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJHG_ECOLI BioCyc ECOL316407:JW4259-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4259-MONOMER BioCyc EcoCyc:G7910-MONOMER http://biocyc.org/getid?id=EcoCyc:G7910-MONOMER BioCyc MetaCyc:G7910-MONOMER http://biocyc.org/getid?id=MetaCyc:G7910-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:4.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 4.-.-.- http://enzyme.expasy.org/EC/4.-.-.- EchoBASE EB2437 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2437 EcoGene EG12549 http://www.ecogene.org/geneInfo.php?eg_id=EG12549 EnsemblBacteria AAC77253 http://www.ensemblgenomes.org/id/AAC77253 EnsemblBacteria AAC77253 http://www.ensemblgenomes.org/id/AAC77253 EnsemblBacteria BAE78288 http://www.ensemblgenomes.org/id/BAE78288 EnsemblBacteria BAE78288 http://www.ensemblgenomes.org/id/BAE78288 EnsemblBacteria BAE78288 http://www.ensemblgenomes.org/id/BAE78288 EnsemblBacteria b4297 http://www.ensemblgenomes.org/id/b4297 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0050401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050401 GO_process GO:0009082 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009082 GO_process GO:0046176 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046176 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 946829 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946829 HOGENOM HOG000173155 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000173155&db=HOGENOM6 IntAct P39358 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39358* IntEnz 4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4 InterPro IPR000581 http://www.ebi.ac.uk/interpro/entry/IPR000581 InterPro IPR015928 http://www.ebi.ac.uk/interpro/entry/IPR015928 InterPro IPR017798 http://www.ebi.ac.uk/interpro/entry/IPR017798 InterPro IPR020558 http://www.ebi.ac.uk/interpro/entry/IPR020558 KEGG_Gene ecj:JW4259 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4259 KEGG_Gene eco:b4297 http://www.genome.jp/dbget-bin/www_bget?eco:b4297 MINT MINT-1250336 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1250336 OMA TMRGHAY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TMRGHAY PANTHER PTHR21000 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21000 PROSITE PS00886 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00886 PROSITE PS00887 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00887 PSORT swissprot:YJHG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJHG_ECOLI PSORT-B swissprot:YJHG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJHG_ECOLI PSORT2 swissprot:YJHG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJHG_ECOLI Pfam PF00920 http://pfam.xfam.org/family/PF00920 Phobius swissprot:YJHG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJHG_ECOLI PhylomeDB P39358 http://phylomedb.org/?seqid=P39358 ProteinModelPortal P39358 http://www.proteinmodelportal.org/query/uniprot/P39358 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418717 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418717 RefSeq WP_000116326 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000116326 STRING 511145.b4297 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4297&targetmode=cogs SUPFAM SSF52016 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52016 TIGRFAMs TIGR03432 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03432 UniProtKB YJHG_ECOLI http://www.uniprot.org/uniprot/YJHG_ECOLI UniProtKB-AC P39358 http://www.uniprot.org/uniprot/P39358 charge swissprot:YJHG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJHG_ECOLI eggNOG COG0129 http://eggnogapi.embl.de/nog_data/html/tree/COG0129 eggNOG ENOG4105C01 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C01 epestfind swissprot:YJHG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJHG_ECOLI garnier swissprot:YJHG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJHG_ECOLI helixturnhelix swissprot:YJHG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJHG_ECOLI hmoment swissprot:YJHG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJHG_ECOLI iep swissprot:YJHG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJHG_ECOLI inforesidue swissprot:YJHG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJHG_ECOLI octanol swissprot:YJHG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJHG_ECOLI pepcoil swissprot:YJHG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJHG_ECOLI pepdigest swissprot:YJHG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJHG_ECOLI pepinfo swissprot:YJHG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJHG_ECOLI pepnet swissprot:YJHG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJHG_ECOLI pepstats swissprot:YJHG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJHG_ECOLI pepwheel swissprot:YJHG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJHG_ECOLI pepwindow swissprot:YJHG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJHG_ECOLI sigcleave swissprot:YJHG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJHG_ECOLI ## Database ID URL or Descriptions # AltName Copper homeostasis protein CutF {ECO:0000303|PubMed 7635807} # BioGrid 4260842 204 # DISRUPTION PHENOTYPE NLPE_ECOLI No visible phenotype (PubMed 7635808). Slightly copper sensitive (PubMed 7635807). Decreased numbers of stationary phase cells bind to hydrophobic surfaces, cellular adhesion has altered dynamic properties; no induction of cpxR when cells bind to hydrophobic surfaces (PubMed 11830644). {ECO 0000269|PubMed 11830644, ECO 0000269|PubMed 7635807, ECO 0000269|PubMed 7635808}. # DOMAIN NLPE_ECOLI The mature protein has 2 domains, the N-terminus (residues 21-100) and the C-terminus (residues 126-236) joined by a flexible linker; both domains form beta-barrels. In the crystal structure of the soluble mutant (Ala-21) the N-terminus of 1 subunit interacts with the C-terminus of the other. {ECO 0000269|PubMed 17698001}. # EcoGene EG12137 nlpE # FUNCTION NLPE_ECOLI Involved in copper homeostasis, could be involved in both copper efflux and the delivery of copper to copper-dependent enzymes (PubMed 7635807). Required for efficient binding of stationary phase cells to hydrophobic surfaces, part of the process of biofilm formation (PubMed 11830644). Functions during envelope stress responses; when overproduced induces degP through the activation of the two-component envelope stress response system CpxA/CpxR (PubMed 7635808, PubMed 15252048). DegP induction seems to require membrane anchoring of this protein (PubMed 15252048). Structural changes and/or interaction of the CXXC motif with its environment may lead to activation of the Cpx stress response (PubMed 17698001). {ECO 0000269|PubMed 11830644, ECO 0000269|PubMed 15252048, ECO 0000269|PubMed 17698001, ECO 0000269|PubMed 7635808}. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_process GO:0007155 cell adhesion; IEA:UniProtKB-KW. # GO_process GO:0010810 regulation of cell-substrate adhesion; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0007155 cell adhesion # GOslim_process GO:0008150 biological_process # IntAct P40710 3 # InterPro IPR007298 Cu-R_lipoprotein_NlpE # InterPro IPR033450 NlpE_C # Organism NLPE_ECOLI Escherichia coli (strain K12) # PATRIC 32115497 VBIEscCol129921_0200 # PDB 2Z4H X-ray; 2.80 A; A/B=21-236 # PDB 2Z4I X-ray; 2.60 A; A/B=21-236 # PIR H64743 H64743 # PROSITE PS51257 PROKAR_LIPOPROTEIN # PTM NLPE_ECOLI Palmitoylated. {ECO 0000269|PubMed 7635808}. # PTM NLPE_ECOLI Seems to only form a disulfide bond between Cys-165 and Cys- 231. The 2 other cysteine residues may however be chemically active. {ECO 0000269|Ref.4}. # Pfam PF04170 NlpE # Pfam PF17185 NlpE_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Lipoprotein NlpE {ECO:0000303|PubMed 7635808} # RefSeq NP_414734 NC_000913.3 # RefSeq WP_000239163 NZ_LN832404.1 # SUBCELLULAR LOCATION NLPE_ECOLI Cell outer membrane {ECO 0000269|PubMed 15252048, ECO 0000305|PubMed 7635808}; Lipid- anchor {ECO 0000305|PubMed 15252048, ECO 0000305|PubMed 7635808}. # SUBUNIT Probably exists as a monomer in vivo, can however form homodimers which swap domains (PubMed:17698001). {ECO 0000269|PubMed:17698001}. # eggNOG COG3015 LUCA # eggNOG ENOG4107EII Bacteria BLAST swissprot:NLPE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NLPE_ECOLI BioCyc ECOL316407:JW0188-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0188-MONOMER BioCyc EcoCyc:EG12137-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12137-MONOMER COG COG3015 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3015 DIP DIP-9353N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9353N DOI 10.1016/j.str.2007.06.014 http://dx.doi.org/10.1016/j.str.2007.06.014 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.042521699 http://dx.doi.org/10.1073/pnas.042521699 DOI 10.1074/jbc.M406390200 http://dx.doi.org/10.1074/jbc.M406390200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D49445 http://www.ebi.ac.uk/ena/data/view/D49445 EMBL L38619 http://www.ebi.ac.uk/ena/data/view/L38619 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18345 http://www.ebi.ac.uk/ena/data/view/U18345 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EchoBASE EB2058 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2058 EcoGene EG12137 http://www.ecogene.org/geneInfo.php?eg_id=EG12137 EnsemblBacteria AAC73303 http://www.ensemblgenomes.org/id/AAC73303 EnsemblBacteria AAC73303 http://www.ensemblgenomes.org/id/AAC73303 EnsemblBacteria BAA77868 http://www.ensemblgenomes.org/id/BAA77868 EnsemblBacteria BAA77868 http://www.ensemblgenomes.org/id/BAA77868 EnsemblBacteria BAA77868 http://www.ensemblgenomes.org/id/BAA77868 EnsemblBacteria b0192 http://www.ensemblgenomes.org/id/b0192 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GO_process GO:0010810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010810 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 946782 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946782 HOGENOM HOG000116933 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000116933&db=HOGENOM6 InParanoid P40710 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P40710 IntAct P40710 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P40710* InterPro IPR007298 http://www.ebi.ac.uk/interpro/entry/IPR007298 InterPro IPR033450 http://www.ebi.ac.uk/interpro/entry/IPR033450 KEGG_Gene ecj:JW0188 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0188 KEGG_Gene eco:b0192 http://www.genome.jp/dbget-bin/www_bget?eco:b0192 KEGG_Orthology KO:K06079 http://www.genome.jp/dbget-bin/www_bget?KO:K06079 OMA GTWVMNQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GTWVMNQ PDB 2Z4H http://www.ebi.ac.uk/pdbe-srv/view/entry/2Z4H PDB 2Z4I http://www.ebi.ac.uk/pdbe-srv/view/entry/2Z4I PDBsum 2Z4H http://www.ebi.ac.uk/pdbsum/2Z4H PDBsum 2Z4I http://www.ebi.ac.uk/pdbsum/2Z4I PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:NLPE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NLPE_ECOLI PSORT-B swissprot:NLPE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NLPE_ECOLI PSORT2 swissprot:NLPE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NLPE_ECOLI Pfam PF04170 http://pfam.xfam.org/family/PF04170 Pfam PF17185 http://pfam.xfam.org/family/PF17185 Phobius swissprot:NLPE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NLPE_ECOLI ProteinModelPortal P40710 http://www.proteinmodelportal.org/query/uniprot/P40710 PubMed 11830644 http://www.ncbi.nlm.nih.gov/pubmed/11830644 PubMed 15252048 http://www.ncbi.nlm.nih.gov/pubmed/15252048 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17698001 http://www.ncbi.nlm.nih.gov/pubmed/17698001 PubMed 7635807 http://www.ncbi.nlm.nih.gov/pubmed/7635807 PubMed 7635808 http://www.ncbi.nlm.nih.gov/pubmed/7635808 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414734 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414734 RefSeq WP_000239163 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000239163 SMR P40710 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P40710 STRING 511145.b0192 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0192&targetmode=cogs STRING COG3015 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3015&targetmode=cogs UniProtKB NLPE_ECOLI http://www.uniprot.org/uniprot/NLPE_ECOLI UniProtKB-AC P40710 http://www.uniprot.org/uniprot/P40710 charge swissprot:NLPE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NLPE_ECOLI eggNOG COG3015 http://eggnogapi.embl.de/nog_data/html/tree/COG3015 eggNOG ENOG4107EII http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107EII epestfind swissprot:NLPE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NLPE_ECOLI garnier swissprot:NLPE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NLPE_ECOLI helixturnhelix swissprot:NLPE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NLPE_ECOLI hmoment swissprot:NLPE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NLPE_ECOLI iep swissprot:NLPE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NLPE_ECOLI inforesidue swissprot:NLPE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NLPE_ECOLI octanol swissprot:NLPE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NLPE_ECOLI pepcoil swissprot:NLPE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NLPE_ECOLI pepdigest swissprot:NLPE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NLPE_ECOLI pepinfo swissprot:NLPE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NLPE_ECOLI pepnet swissprot:NLPE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NLPE_ECOLI pepstats swissprot:NLPE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NLPE_ECOLI pepwheel swissprot:NLPE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NLPE_ECOLI pepwindow swissprot:NLPE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NLPE_ECOLI sigcleave swissprot:NLPE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NLPE_ECOLI ## Database ID URL or Descriptions # BioGrid 4259382 6 # DISRUPTION PHENOTYPE Simultaneous disruption of erfK, ybiS, ycfS and ynhG leads to loss of covalent anchoring of the major outer membrane lipoprotein (Lpp, also known as the Braun lipoprotein) to the peptidoglycan. Complementation with erfK restores some of this anchoring. {ECO:0000269|PubMed 18456808}. # EcoGene EG12682 erfK # FUNCTION ERFK_ECOLI Responsible, at least in part, for anchoring of the major outer membrane lipoprotein (Lpp, also known as the Braun lipoprotein) to the peptidoglycan via a meso-diaminopimelyl-L-Lys- bond on the terminal residue of Lpp. {ECO 0000269|PubMed 18456808}. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_function GO:0016755 transferase activity, transferring amino-acyl groups; IMP:EcoCyc. # GO_function GO:0016757 transferase activity, transferring glycosyl groups; IEA:UniProtKB-KW. # GO_function GO:0016807 cysteine-type carboxypeptidase activity; IMP:EcoCyc. # GO_function GO:0071972 peptidoglycan L,D-transpeptidase activity; IMP:EcoCyc. # GO_process GO:0008360 regulation of cell shape; IEA:UniProtKB-KW. # GO_process GO:0018104 peptidoglycan-protein cross-linking; IMP:EcoCyc. # GO_process GO:0043164 Gram-negative-bacterium-type cell wall biogenesis; IMP:EcoCyc. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0071554 cell wall organization or biogenesis # INTERACTION ERFK_ECOLI P08312 pheS; NbExp=3; IntAct=EBI-555707, EBI-555676; # IntAct P39176 2 # InterPro IPR005490 LD_TPept_cat_dom # KEGG_Brite ko01002 Peptidases # Organism ERFK_ECOLI Escherichia coli (strain K12) # PATHWAY ERFK_ECOLI Cell wall biogenesis; peptidoglycan biosynthesis. # PATRIC 32119311 VBIEscCol129921_2065 # PIR E64963 E64963 # Pfam PF03734 YkuD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ERFK_ECOLI Probable L,D-transpeptidase ErfK/SrfK # RefSeq NP_416494 NC_000913.3 # RefSeq WP_001350523 NZ_LN832404.1 # SIMILARITY Belongs to the YkuD family. {ECO 0000305}. # SUBCELLULAR LOCATION ERFK_ECOLI Periplasm {ECO 0000305}. # SUBUNIT Interacts with DsbG. {ECO:0000269|PubMed 19965429}. # eggNOG COG1376 LUCA # eggNOG ENOG4108PXI Bacteria BLAST swissprot:ERFK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ERFK_ECOLI BioCyc ECOL316407:JW1968-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1968-MONOMER BioCyc EcoCyc:G7073-MONOMER http://biocyc.org/getid?id=EcoCyc:G7073-MONOMER BioCyc MetaCyc:G7073-MONOMER http://biocyc.org/getid?id=MetaCyc:G7073-MONOMER COG COG1376 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1376 DIP DIP-9522N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9522N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.1179557 http://dx.doi.org/10.1126/science.1179557 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00025-08 http://dx.doi.org/10.1128/JB.00025-08 EC_number EC:2.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:2.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U33333 http://www.ebi.ac.uk/ena/data/view/U33333 ENZYME 2.-.-.- http://enzyme.expasy.org/EC/2.-.-.- EchoBASE EB2546 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2546 EcoGene EG12682 http://www.ecogene.org/geneInfo.php?eg_id=EG12682 EnsemblBacteria AAC75051 http://www.ensemblgenomes.org/id/AAC75051 EnsemblBacteria AAC75051 http://www.ensemblgenomes.org/id/AAC75051 EnsemblBacteria BAA15807 http://www.ensemblgenomes.org/id/BAA15807 EnsemblBacteria BAA15807 http://www.ensemblgenomes.org/id/BAA15807 EnsemblBacteria BAA15807 http://www.ensemblgenomes.org/id/BAA15807 EnsemblBacteria b1990 http://www.ensemblgenomes.org/id/b1990 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0016755 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016755 GO_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GO_function GO:0016807 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016807 GO_function GO:0071972 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071972 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0018104 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018104 GO_process GO:0043164 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043164 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 GeneID 945273 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945273 HOGENOM HOG000274378 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000274378&db=HOGENOM6 InParanoid P39176 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39176 IntAct P39176 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39176* IntEnz 2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2 InterPro IPR005490 http://www.ebi.ac.uk/interpro/entry/IPR005490 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW1968 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1968 KEGG_Gene eco:b1990 http://www.genome.jp/dbget-bin/www_bget?eco:b1990 KEGG_Orthology KO:K16291 http://www.genome.jp/dbget-bin/www_bget?KO:K16291 MINT MINT-1229758 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1229758 OMA QWITSIK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QWITSIK PSORT swissprot:ERFK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ERFK_ECOLI PSORT-B swissprot:ERFK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ERFK_ECOLI PSORT2 swissprot:ERFK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ERFK_ECOLI Pfam PF03734 http://pfam.xfam.org/family/PF03734 Phobius swissprot:ERFK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ERFK_ECOLI PhylomeDB P39176 http://phylomedb.org/?seqid=P39176 ProteinModelPortal P39176 http://www.proteinmodelportal.org/query/uniprot/P39176 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18456808 http://www.ncbi.nlm.nih.gov/pubmed/18456808 PubMed 19965429 http://www.ncbi.nlm.nih.gov/pubmed/19965429 PubMed 7592411 http://www.ncbi.nlm.nih.gov/pubmed/7592411 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_416494 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416494 RefSeq WP_001350523 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001350523 SMR P39176 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39176 STRING 511145.b1990 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1990&targetmode=cogs STRING COG1376 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1376&targetmode=cogs UniProtKB ERFK_ECOLI http://www.uniprot.org/uniprot/ERFK_ECOLI UniProtKB-AC P39176 http://www.uniprot.org/uniprot/P39176 charge swissprot:ERFK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ERFK_ECOLI eggNOG COG1376 http://eggnogapi.embl.de/nog_data/html/tree/COG1376 eggNOG ENOG4108PXI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108PXI epestfind swissprot:ERFK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ERFK_ECOLI garnier swissprot:ERFK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ERFK_ECOLI helixturnhelix swissprot:ERFK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ERFK_ECOLI hmoment swissprot:ERFK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ERFK_ECOLI iep swissprot:ERFK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ERFK_ECOLI inforesidue swissprot:ERFK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ERFK_ECOLI octanol swissprot:ERFK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ERFK_ECOLI pepcoil swissprot:ERFK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ERFK_ECOLI pepdigest swissprot:ERFK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ERFK_ECOLI pepinfo swissprot:ERFK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ERFK_ECOLI pepnet swissprot:ERFK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ERFK_ECOLI pepstats swissprot:ERFK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ERFK_ECOLI pepwheel swissprot:ERFK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ERFK_ECOLI pepwindow swissprot:ERFK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ERFK_ECOLI sigcleave swissprot:ERFK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ERFK_ECOLI ## Database ID URL or Descriptions # BioGrid 4261790 11 # EcoGene EG11466 rarD # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IEA:InterPro. # GO_component GO:0016021 integral component of membrane; IDA:EcoCyc. # GO_function GO:0005215 transporter activity; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # InterPro IPR000620 EamA_dom # InterPro IPR004626 RarD # KEGG_Brite ko02000 Transporters # Organism RARD_ECOLI Escherichia coli (strain K12) # PATRIC 32123139 VBIEscCol129921_3935 # PIR S30709 S30709 # PIR S30746 S30746 # Pfam PF00892 EamA; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RARD_ECOLI Protein RarD # RefSeq WP_000339104 NZ_LN832404.1 # RefSeq YP_026262 NC_000913.3 # SIMILARITY Belongs to the EamA transporter family. {ECO 0000305}. # SIMILARITY Contains 1 EamA domain. {ECO 0000305}. # SUBCELLULAR LOCATION RARD_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.7.7 the drug/metabolite transporter (dmt) superfamily # TIGRFAMs TIGR00688 rarD # eggNOG COG2962 LUCA # eggNOG ENOG4105FR1 Bacteria BLAST swissprot:RARD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RARD_ECOLI BioCyc ECOL316407:JW5589-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5589-MONOMER BioCyc EcoCyc:EG11466-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11466-MONOMER COG COG2962 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2962 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L02122 http://www.ebi.ac.uk/ena/data/view/L02122 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1434 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1434 EcoGene EG11466 http://www.ecogene.org/geneInfo.php?eg_id=EG11466 EnsemblBacteria AAT48220 http://www.ensemblgenomes.org/id/AAT48220 EnsemblBacteria AAT48220 http://www.ensemblgenomes.org/id/AAT48220 EnsemblBacteria BAE77482 http://www.ensemblgenomes.org/id/BAE77482 EnsemblBacteria BAE77482 http://www.ensemblgenomes.org/id/BAE77482 EnsemblBacteria BAE77482 http://www.ensemblgenomes.org/id/BAE77482 EnsemblBacteria b3819 http://www.ensemblgenomes.org/id/b3819 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GeneID 948330 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948330 HOGENOM HOG000262547 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000262547&db=HOGENOM6 InParanoid P27844 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P27844 InterPro IPR000620 http://www.ebi.ac.uk/interpro/entry/IPR000620 InterPro IPR004626 http://www.ebi.ac.uk/interpro/entry/IPR004626 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5589 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5589 KEGG_Gene eco:b3819 http://www.genome.jp/dbget-bin/www_bget?eco:b3819 KEGG_Orthology KO:K05786 http://www.genome.jp/dbget-bin/www_bget?KO:K05786 OMA IWAVNNN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IWAVNNN PSORT swissprot:RARD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RARD_ECOLI PSORT-B swissprot:RARD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RARD_ECOLI PSORT2 swissprot:RARD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RARD_ECOLI Pfam PF00892 http://pfam.xfam.org/family/PF00892 Phobius swissprot:RARD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RARD_ECOLI PhylomeDB P27844 http://phylomedb.org/?seqid=P27844 ProteinModelPortal P27844 http://www.proteinmodelportal.org/query/uniprot/P27844 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000339104 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000339104 RefSeq YP_026262 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026262 STRING 511145.b3819 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3819&targetmode=cogs STRING COG2962 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2962&targetmode=cogs TCDB 2.A.7.7 http://www.tcdb.org/search/result.php?tc=2.A.7.7 TIGRFAMs TIGR00688 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00688 UniProtKB RARD_ECOLI http://www.uniprot.org/uniprot/RARD_ECOLI UniProtKB-AC P27844 http://www.uniprot.org/uniprot/P27844 charge swissprot:RARD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RARD_ECOLI eggNOG COG2962 http://eggnogapi.embl.de/nog_data/html/tree/COG2962 eggNOG ENOG4105FR1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FR1 epestfind swissprot:RARD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RARD_ECOLI garnier swissprot:RARD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RARD_ECOLI helixturnhelix swissprot:RARD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RARD_ECOLI hmoment swissprot:RARD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RARD_ECOLI iep swissprot:RARD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RARD_ECOLI inforesidue swissprot:RARD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RARD_ECOLI octanol swissprot:RARD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RARD_ECOLI pepcoil swissprot:RARD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RARD_ECOLI pepdigest swissprot:RARD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RARD_ECOLI pepinfo swissprot:RARD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RARD_ECOLI pepnet swissprot:RARD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RARD_ECOLI pepstats swissprot:RARD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RARD_ECOLI pepwheel swissprot:RARD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RARD_ECOLI pepwindow swissprot:RARD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RARD_ECOLI sigcleave swissprot:RARD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RARD_ECOLI ## Database ID URL or Descriptions # BioGrid 4259770 205 # CATALYTIC ACTIVITY FADE_ECOLI An acyl-CoA + FAD = a dehydrogenated acyl-CoA + FADH(2). # CAUTION Was originally named fadF. {ECO 0000305}. # EcoGene EG13145 fadE # FUNCTION FADE_ECOLI Catalyzes the dehydrogenation of acyl-CoA. {ECO 0000269|PubMed 12057976}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_function GO:0000062 fatty-acyl-CoA binding; IBA:GO_Central. # GO_function GO:0003995 acyl-CoA dehydrogenase activity; IMP:EcoCyc. # GO_function GO:0009055 electron carrier activity; IBA:GO_Central. # GO_function GO:0050660 flavin adenine dinucleotide binding; IBA:GO_Central. # GO_function GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor; IBA:GO_Central. # GO_process GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase; IMP:EcoCyc. # GO_process GO:0055088 lipid homeostasis; IBA:GO_Central. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0042592 homeostatic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.540.10 -; 1. # INDUCTION FADE_ECOLI Negatively regulated by FadR. # InterPro IPR006091 Acyl-CoA_Oxase/DH_cen-dom # InterPro IPR009075 AcylCo_DH/oxidase_C # InterPro IPR009100 AcylCoA_DH/oxidase_NM_dom # InterPro IPR013786 AcylCoA_DH/ox_N # InterPro IPR015396 DUF1974 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00071 Fatty acid metabolism # Organism FADE_ECOLI Escherichia coli (strain K12) # PATHWAY FADE_ECOLI Lipid metabolism; fatty acid beta-oxidation. # PATRIC 32115557 VBIEscCol129921_0223 # PIR F64746 F64746 # Pfam PF00441 Acyl-CoA_dh_1 # Pfam PF02770 Acyl-CoA_dh_M # Pfam PF02771 Acyl-CoA_dh_N # Pfam PF09317 DUF1974 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FADE_ECOLI Acyl-coenzyme A dehydrogenase # RefSeq NP_414756 NC_000913.3 # RefSeq WP_000973083 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA07583.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the acyl-CoA dehydrogenase family. {ECO 0000305}. # SUPFAM SSF47203 SSF47203 # SUPFAM SSF56645 SSF56645 # eggNOG COG1960 LUCA # eggNOG ENOG4107QPN Bacteria BLAST swissprot:FADE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FADE_ECOLI BioCyc ECOL316407:JW5020-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5020-MONOMER BioCyc EcoCyc:ACYLCOADEHYDROG-MONOMER http://biocyc.org/getid?id=EcoCyc:ACYLCOADEHYDROG-MONOMER BioCyc MetaCyc:ACYLCOADEHYDROG-MONOMER http://biocyc.org/getid?id=MetaCyc:ACYLCOADEHYDROG-MONOMER COG COG1960 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1960 DOI 10.1016/0165-7992(95)90024-1 http://dx.doi.org/10.1016/0165-7992(95)90024-1 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.13.3759-3764.2002 http://dx.doi.org/10.1128/JB.184.13.3759-3764.2002 EC_number EC:1.3.99.- http://www.genome.jp/dbget-bin/www_bget?EC:1.3.99.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D38582 http://www.ebi.ac.uk/ena/data/view/D38582 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 ENZYME 1.3.99.- http://enzyme.expasy.org/EC/1.3.99.- EchoBASE EB2939 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2939 EcoGene EG13145 http://www.ecogene.org/geneInfo.php?eg_id=EG13145 EnsemblBacteria AAC73325 http://www.ensemblgenomes.org/id/AAC73325 EnsemblBacteria AAC73325 http://www.ensemblgenomes.org/id/AAC73325 EnsemblBacteria BAA77891 http://www.ensemblgenomes.org/id/BAA77891 EnsemblBacteria BAA77891 http://www.ensemblgenomes.org/id/BAA77891 EnsemblBacteria BAA77891 http://www.ensemblgenomes.org/id/BAA77891 EnsemblBacteria b0221 http://www.ensemblgenomes.org/id/b0221 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0000062 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000062 GO_function GO:0003995 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003995 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_function GO:0052890 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052890 GO_process GO:0033539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033539 GO_process GO:0055088 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055088 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.540.10 http://www.cathdb.info/version/latest/superfamily/1.10.540.10 GeneID 949007 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949007 HOGENOM HOG000274434 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000274434&db=HOGENOM6 InParanoid Q47146 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q47146 IntEnz 1.3.99 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.3.99 InterPro IPR006091 http://www.ebi.ac.uk/interpro/entry/IPR006091 InterPro IPR009075 http://www.ebi.ac.uk/interpro/entry/IPR009075 InterPro IPR009100 http://www.ebi.ac.uk/interpro/entry/IPR009100 InterPro IPR013786 http://www.ebi.ac.uk/interpro/entry/IPR013786 InterPro IPR015396 http://www.ebi.ac.uk/interpro/entry/IPR015396 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5020 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5020 KEGG_Gene eco:b0221 http://www.genome.jp/dbget-bin/www_bget?eco:b0221 KEGG_Orthology KO:K06445 http://www.genome.jp/dbget-bin/www_bget?KO:K06445 KEGG_Pathway ko00071 http://www.genome.jp/kegg-bin/show_pathway?ko00071 KEGG_Reaction rn:R01175 http://www.genome.jp/dbget-bin/www_bget?rn:R01175 KEGG_Reaction rn:R01279 http://www.genome.jp/dbget-bin/www_bget?rn:R01279 KEGG_Reaction rn:R03777 http://www.genome.jp/dbget-bin/www_bget?rn:R03777 KEGG_Reaction rn:R03857 http://www.genome.jp/dbget-bin/www_bget?rn:R03857 KEGG_Reaction rn:R03990 http://www.genome.jp/dbget-bin/www_bget?rn:R03990 KEGG_Reaction rn:R04751 http://www.genome.jp/dbget-bin/www_bget?rn:R04751 KEGG_Reaction rn:R04754 http://www.genome.jp/dbget-bin/www_bget?rn:R04754 OMA NDFEITH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NDFEITH PSORT swissprot:FADE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FADE_ECOLI PSORT-B swissprot:FADE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FADE_ECOLI PSORT2 swissprot:FADE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FADE_ECOLI Pfam PF00441 http://pfam.xfam.org/family/PF00441 Pfam PF02770 http://pfam.xfam.org/family/PF02770 Pfam PF02771 http://pfam.xfam.org/family/PF02771 Pfam PF09317 http://pfam.xfam.org/family/PF09317 Phobius swissprot:FADE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FADE_ECOLI PhylomeDB Q47146 http://phylomedb.org/?seqid=Q47146 ProteinModelPortal Q47146 http://www.proteinmodelportal.org/query/uniprot/Q47146 PubMed 12057976 http://www.ncbi.nlm.nih.gov/pubmed/12057976 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7596361 http://www.ncbi.nlm.nih.gov/pubmed/7596361 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414756 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414756 RefSeq WP_000973083 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000973083 STRING 511145.b0221 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0221&targetmode=cogs STRING COG1960 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1960&targetmode=cogs SUPFAM SSF47203 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47203 SUPFAM SSF56645 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56645 UniProtKB FADE_ECOLI http://www.uniprot.org/uniprot/FADE_ECOLI UniProtKB-AC Q47146 http://www.uniprot.org/uniprot/Q47146 charge swissprot:FADE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FADE_ECOLI eggNOG COG1960 http://eggnogapi.embl.de/nog_data/html/tree/COG1960 eggNOG ENOG4107QPN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QPN epestfind swissprot:FADE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FADE_ECOLI garnier swissprot:FADE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FADE_ECOLI helixturnhelix swissprot:FADE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FADE_ECOLI hmoment swissprot:FADE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FADE_ECOLI iep swissprot:FADE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FADE_ECOLI inforesidue swissprot:FADE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FADE_ECOLI octanol swissprot:FADE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FADE_ECOLI pepcoil swissprot:FADE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FADE_ECOLI pepdigest swissprot:FADE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FADE_ECOLI pepinfo swissprot:FADE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FADE_ECOLI pepnet swissprot:FADE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FADE_ECOLI pepstats swissprot:FADE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FADE_ECOLI pepwheel swissprot:FADE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FADE_ECOLI pepwindow swissprot:FADE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FADE_ECOLI sigcleave swissprot:FADE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FADE_ECOLI ## Database ID URL or Descriptions # BRENDA 1.1.1.350 2026 # BioGrid 4261441 91 # CATALYTIC ACTIVITY ALLD_ECOLI (S)-ureidoglycolate + NAD(+) = oxalurate + NADH. # EcoGene EG13624 allD # FUNCTION ALLD_ECOLI Involved in the anaerobic utilization of allantoin. {ECO 0000269|PubMed 10601204}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0009040 ureidoglycolate dehydrogenase activity; IDA:EcoCyc. # GO_process GO:0006144 purine nucleobase metabolic process; IEA:UniProtKB-KW. # GO_process GO:0009442 allantoin assimilation pathway; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # INDUCTION ALLD_ECOLI By glyoxylate and allantoin under anaerobic conditions. # IntAct P77555 5 # InterPro IPR003767 Malate/L-lactate_DH # InterPro IPR017590 Ureidoglycolate_dehydrogenase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # Organism ALLD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11091 PTHR11091 # PATHWAY Nitrogen metabolism; (S)-allantoin degradation; oxalurate from (S)-ureidoglycolate step 1/1. # PATRIC 32116191 VBIEscCol129921_0537 # PDB 1XRH X-ray; 2.25 A; A/B/C/D/E/F/G/H=2-349 # PDB 4H8A X-ray; 1.64 A; A/B=1-337 # PIR D64783 D64783 # Pfam PF02615 Ldh_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ALLD_ECOLI Ureidoglycolate dehydrogenase (NAD(+)) # RefSeq NP_415050 NC_000913.3 # RefSeq WP_000703900 NZ_LN832404.1 # SIMILARITY Belongs to the LDH2/MDH2 oxidoreductase family. {ECO 0000305}. # SUBCELLULAR LOCATION ALLD_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF89733 SSF89733 # TIGRFAMs TIGR03175 AllD # UniPathway UPA00395 UER00657 # eggNOG COG2055 LUCA # eggNOG ENOG4105DG4 Bacteria BLAST swissprot:ALLD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ALLD_ECOLI BioCyc ECOL316407:JW0505-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0505-MONOMER BioCyc EcoCyc:G6286-MONOMER http://biocyc.org/getid?id=EcoCyc:G6286-MONOMER BioCyc MetaCyc:G6286-MONOMER http://biocyc.org/getid?id=MetaCyc:G6286-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.350 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.350 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL U89279 http://www.ebi.ac.uk/ena/data/view/U89279 ENZYME 1.1.1.350 http://enzyme.expasy.org/EC/1.1.1.350 EchoBASE EB3389 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3389 EcoGene EG13624 http://www.ecogene.org/geneInfo.php?eg_id=EG13624 EnsemblBacteria AAC73619 http://www.ensemblgenomes.org/id/AAC73619 EnsemblBacteria AAC73619 http://www.ensemblgenomes.org/id/AAC73619 EnsemblBacteria BAE76295 http://www.ensemblgenomes.org/id/BAE76295 EnsemblBacteria BAE76295 http://www.ensemblgenomes.org/id/BAE76295 EnsemblBacteria BAE76295 http://www.ensemblgenomes.org/id/BAE76295 EnsemblBacteria b0517 http://www.ensemblgenomes.org/id/b0517 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0009040 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009040 GO_process GO:0006144 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006144 GO_process GO:0009442 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009442 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 948342 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948342 HOGENOM HOG000173270 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000173270&db=HOGENOM6 InParanoid P77555 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77555 IntAct P77555 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77555* IntEnz 1.1.1.350 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.350 InterPro IPR003767 http://www.ebi.ac.uk/interpro/entry/IPR003767 InterPro IPR017590 http://www.ebi.ac.uk/interpro/entry/IPR017590 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0505 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0505 KEGG_Gene eco:b0517 http://www.genome.jp/dbget-bin/www_bget?eco:b0517 KEGG_Orthology KO:K00073 http://www.genome.jp/dbget-bin/www_bget?KO:K00073 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Reaction rn:R02935 http://www.genome.jp/dbget-bin/www_bget?rn:R02935 KEGG_Reaction rn:R02936 http://www.genome.jp/dbget-bin/www_bget?rn:R02936 OMA ERIPPSW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ERIPPSW PANTHER PTHR11091 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11091 PDB 1XRH http://www.ebi.ac.uk/pdbe-srv/view/entry/1XRH PDB 4H8A http://www.ebi.ac.uk/pdbe-srv/view/entry/4H8A PDBsum 1XRH http://www.ebi.ac.uk/pdbsum/1XRH PDBsum 4H8A http://www.ebi.ac.uk/pdbsum/4H8A PSORT swissprot:ALLD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ALLD_ECOLI PSORT-B swissprot:ALLD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ALLD_ECOLI PSORT2 swissprot:ALLD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ALLD_ECOLI Pfam PF02615 http://pfam.xfam.org/family/PF02615 Phobius swissprot:ALLD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ALLD_ECOLI PhylomeDB P77555 http://phylomedb.org/?seqid=P77555 ProteinModelPortal P77555 http://www.proteinmodelportal.org/query/uniprot/P77555 PubMed 10601204 http://www.ncbi.nlm.nih.gov/pubmed/10601204 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415050 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415050 RefSeq WP_000703900 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000703900 SMR P77555 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77555 STRING 511145.b0517 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0517&targetmode=cogs SUPFAM SSF89733 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF89733 TIGRFAMs TIGR03175 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03175 UniProtKB ALLD_ECOLI http://www.uniprot.org/uniprot/ALLD_ECOLI UniProtKB-AC P77555 http://www.uniprot.org/uniprot/P77555 charge swissprot:ALLD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ALLD_ECOLI eggNOG COG2055 http://eggnogapi.embl.de/nog_data/html/tree/COG2055 eggNOG ENOG4105DG4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DG4 epestfind swissprot:ALLD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ALLD_ECOLI garnier swissprot:ALLD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ALLD_ECOLI helixturnhelix swissprot:ALLD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ALLD_ECOLI hmoment swissprot:ALLD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ALLD_ECOLI iep swissprot:ALLD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ALLD_ECOLI inforesidue swissprot:ALLD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ALLD_ECOLI octanol swissprot:ALLD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ALLD_ECOLI pepcoil swissprot:ALLD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ALLD_ECOLI pepdigest swissprot:ALLD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ALLD_ECOLI pepinfo swissprot:ALLD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ALLD_ECOLI pepnet swissprot:ALLD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ALLD_ECOLI pepstats swissprot:ALLD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ALLD_ECOLI pepwheel swissprot:ALLD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ALLD_ECOLI pepwindow swissprot:ALLD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ALLD_ECOLI sigcleave swissprot:ALLD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ALLD_ECOLI ## Database ID URL or Descriptions # BioGrid 4263343 13 # EcoGene EG13958 ydhX # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0016491 oxidoreductase activity; IBA:GO_Central. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # INDUCTION Up-regulated by the oxygen-responsive transcription factor FNR under anaerobic conditions. Repressed in the presence of nitrate or nitrite via the two-component systems NarXL and NarPQ, respectively. {ECO:0000269|PubMed 18227264}. # InterPro IPR017896 4Fe4S_Fe-S-bd # InterPro IPR017900 4Fe4S_Fe_S_CS # Organism YDHX_ECOLI Escherichia coli (strain K12) # PATRIC 32118648 VBIEscCol129921_1742 # PIR G64924 G64924 # PROSITE PS00198 4FE4S_FER_1 # PROSITE PS51379 4FE4S_FER_2; 3 # PTM YDHX_ECOLI Exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven. Can also be exported by the Sec system. # Pfam PF13247 Fer4_11 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDHX_ECOLI Uncharacterized ferredoxin-like protein YdhX # RefSeq NP_416186 NC_000913.3 # RefSeq WP_001310861 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB47947.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Contains 3 4Fe-4S ferredoxin-type domains. {ECO:0000255|PROSITE-ProRule PRU00711}. # eggNOG COG0437 LUCA # eggNOG ENOG4108393 Bacteria BLAST swissprot:YDHX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDHX_ECOLI BioCyc ECOL316407:JW5271-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5271-MONOMER BioCyc EcoCyc:G6899-MONOMER http://biocyc.org/getid?id=EcoCyc:G6899-MONOMER DIP DIP-48159N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48159N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M610507200 http://dx.doi.org/10.1074/jbc.M610507200 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1099/mic.0.2007/012146-0 http://dx.doi.org/10.1099/mic.0.2007/012146-0 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U68703 http://www.ebi.ac.uk/ena/data/view/U68703 EchoBASE EB3716 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3716 EcoGene EG13958 http://www.ecogene.org/geneInfo.php?eg_id=EG13958 EnsemblBacteria AAC74741 http://www.ensemblgenomes.org/id/AAC74741 EnsemblBacteria AAC74741 http://www.ensemblgenomes.org/id/AAC74741 EnsemblBacteria BAA15443 http://www.ensemblgenomes.org/id/BAA15443 EnsemblBacteria BAA15443 http://www.ensemblgenomes.org/id/BAA15443 EnsemblBacteria BAA15443 http://www.ensemblgenomes.org/id/BAA15443 EnsemblBacteria b1671 http://www.ensemblgenomes.org/id/b1671 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GeneID 947308 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947308 HOGENOM HOG000163388 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000163388&db=HOGENOM6 InParanoid P77375 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77375 InterPro IPR017896 http://www.ebi.ac.uk/interpro/entry/IPR017896 InterPro IPR017900 http://www.ebi.ac.uk/interpro/entry/IPR017900 KEGG_Gene ecj:JW5271 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5271 KEGG_Gene eco:b1671 http://www.genome.jp/dbget-bin/www_bget?eco:b1671 PROSITE PS00198 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00198 PROSITE PS51379 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51379 PSORT swissprot:YDHX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDHX_ECOLI PSORT-B swissprot:YDHX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDHX_ECOLI PSORT2 swissprot:YDHX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDHX_ECOLI Pfam PF13247 http://pfam.xfam.org/family/PF13247 Phobius swissprot:YDHX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDHX_ECOLI PhylomeDB P77375 http://phylomedb.org/?seqid=P77375 ProteinModelPortal P77375 http://www.proteinmodelportal.org/query/uniprot/P77375 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17218314 http://www.ncbi.nlm.nih.gov/pubmed/17218314 PubMed 18227264 http://www.ncbi.nlm.nih.gov/pubmed/18227264 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416186 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416186 RefSeq WP_001310861 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001310861 SMR P77375 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77375 STRING 511145.b1671 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1671&targetmode=cogs UniProtKB YDHX_ECOLI http://www.uniprot.org/uniprot/YDHX_ECOLI UniProtKB-AC P77375 http://www.uniprot.org/uniprot/P77375 charge swissprot:YDHX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDHX_ECOLI eggNOG COG0437 http://eggnogapi.embl.de/nog_data/html/tree/COG0437 eggNOG ENOG4108393 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108393 epestfind swissprot:YDHX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDHX_ECOLI garnier swissprot:YDHX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDHX_ECOLI helixturnhelix swissprot:YDHX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDHX_ECOLI hmoment swissprot:YDHX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDHX_ECOLI iep swissprot:YDHX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDHX_ECOLI inforesidue swissprot:YDHX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDHX_ECOLI octanol swissprot:YDHX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDHX_ECOLI pepcoil swissprot:YDHX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDHX_ECOLI pepdigest swissprot:YDHX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDHX_ECOLI pepinfo swissprot:YDHX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDHX_ECOLI pepnet swissprot:YDHX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDHX_ECOLI pepstats swissprot:YDHX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDHX_ECOLI pepwheel swissprot:YDHX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDHX_ECOLI pepwindow swissprot:YDHX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDHX_ECOLI sigcleave swissprot:YDHX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDHX_ECOLI ## Database ID URL or Descriptions # BioGrid 4261237 2 # EcoGene EG11916 yjaG # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # Gene3D 1.20.1590.10 -; 1. # IntAct P32680 6 # InterPro IPR007338 DUF416 # InterPro IPR023381 YP001051499.1-like_dom # Organism YJAG_ECOLI Escherichia coli (strain K12) # PATRIC 32123521 VBIEscCol129921_4113 # PIR B65207 B65207 # Pfam PF04222 DUF416 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJAG_ECOLI Uncharacterized protein YjaG # RefSeq NP_418427 NC_000913.3 # RefSeq WP_000940106 NZ_LN832404.1 # SIMILARITY To H.influenzae HI_0431. {ECO 0000305}. # eggNOG COG3068 LUCA # eggNOG ENOG4105R2J Bacteria BLAST swissprot:YJAG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJAG_ECOLI BioCyc ECOL316407:JW3963-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3963-MONOMER BioCyc EcoCyc:EG11916-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11916-MONOMER COG COG3068 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3068 DIP DIP-12528N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12528N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1860 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1860 EcoGene EG11916 http://www.ecogene.org/geneInfo.php?eg_id=EG11916 EnsemblBacteria AAC76973 http://www.ensemblgenomes.org/id/AAC76973 EnsemblBacteria AAC76973 http://www.ensemblgenomes.org/id/AAC76973 EnsemblBacteria BAE77320 http://www.ensemblgenomes.org/id/BAE77320 EnsemblBacteria BAE77320 http://www.ensemblgenomes.org/id/BAE77320 EnsemblBacteria BAE77320 http://www.ensemblgenomes.org/id/BAE77320 EnsemblBacteria b3999 http://www.ensemblgenomes.org/id/b3999 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 Gene3D 1.20.1590.10 http://www.cathdb.info/version/latest/superfamily/1.20.1590.10 GeneID 948501 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948501 HOGENOM HOG000283285 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000283285&db=HOGENOM6 IntAct P32680 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32680* InterPro IPR007338 http://www.ebi.ac.uk/interpro/entry/IPR007338 InterPro IPR023381 http://www.ebi.ac.uk/interpro/entry/IPR023381 KEGG_Gene ecj:JW3963 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3963 KEGG_Gene eco:b3999 http://www.genome.jp/dbget-bin/www_bget?eco:b3999 KEGG_Orthology KO:K09891 http://www.genome.jp/dbget-bin/www_bget?KO:K09891 OMA YPAMDAC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YPAMDAC PSORT swissprot:YJAG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJAG_ECOLI PSORT-B swissprot:YJAG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJAG_ECOLI PSORT2 swissprot:YJAG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJAG_ECOLI Pfam PF04222 http://pfam.xfam.org/family/PF04222 Phobius swissprot:YJAG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJAG_ECOLI ProteinModelPortal P32680 http://www.proteinmodelportal.org/query/uniprot/P32680 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418427 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418427 RefSeq WP_000940106 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000940106 SMR P32680 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32680 STRING 511145.b3999 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3999&targetmode=cogs STRING COG3068 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3068&targetmode=cogs UniProtKB YJAG_ECOLI http://www.uniprot.org/uniprot/YJAG_ECOLI UniProtKB-AC P32680 http://www.uniprot.org/uniprot/P32680 charge swissprot:YJAG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJAG_ECOLI eggNOG COG3068 http://eggnogapi.embl.de/nog_data/html/tree/COG3068 eggNOG ENOG4105R2J http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105R2J epestfind swissprot:YJAG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJAG_ECOLI garnier swissprot:YJAG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJAG_ECOLI helixturnhelix swissprot:YJAG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJAG_ECOLI hmoment swissprot:YJAG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJAG_ECOLI iep swissprot:YJAG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJAG_ECOLI inforesidue swissprot:YJAG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJAG_ECOLI octanol swissprot:YJAG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJAG_ECOLI pepcoil swissprot:YJAG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJAG_ECOLI pepdigest swissprot:YJAG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJAG_ECOLI pepinfo swissprot:YJAG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJAG_ECOLI pepnet swissprot:YJAG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJAG_ECOLI pepstats swissprot:YJAG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJAG_ECOLI pepwheel swissprot:YJAG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJAG_ECOLI pepwindow swissprot:YJAG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJAG_ECOLI sigcleave swissprot:YJAG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJAG_ECOLI ## Database ID URL or Descriptions # BioGrid 4263317 66 # CATALYTIC ACTIVITY REP_ECOLI ATP + H(2)O = ADP + phosphate. {ECO 0000255|HAMAP-Rule MF_01920, ECO 0000269|PubMed 1658335, ECO 0000269|PubMed 221901}. # ENZYME REGULATION REP_ECOLI Binding to DNA induces dimerization, which is required for DNA helicase activity. {ECO 0000269|PubMed 11428893, ECO 0000269|PubMed 1658335}. # EcoGene EG10837 rep # FUNCTION REP_ECOLI Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction. {ECO 0000255|HAMAP-Rule MF_01920, ECO 0000269|PubMed 221901}. # GO_function GO:0003697 single-stranded DNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0004003 ATP-dependent DNA helicase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008408 3'-5' exonuclease activity; IEA:UniProtKB-HAMAP. # GO_process GO:0006268 DNA unwinding involved in DNA replication; IDA:EcoCyc. # GO_process GO:0044787 bacterial-type DNA replication; IMP:EcoCyc. # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004386 helicase activity # GOslim_function GO:0004518 nuclease activity # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0051276 chromosome organization # Gene3D 1.10.10.160 -; 1. # Gene3D 3.40.50.300 -; 4. # HAMAP MF_01920 Helicase_Rep # INTERACTION REP_ECOLI P0ACB0 dnaB; NbExp=3; IntAct=EBI-6558011, EBI-548978; # IntAct P09980 4 # InterPro IPR000212 DNA_helicase_UvrD/REP # InterPro IPR005752 Helicase_Rep # InterPro IPR013986 DExx_box_DNA_helicase_dom # InterPro IPR014016 UvrD-like_ATP-bd # InterPro IPR014017 DNA_helicase_UvrD-like_C # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # Organism REP_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11070 PTHR11070 # PATRIC 32123047 VBIEscCol129921_3893 # PDB 1UAA X-ray; 3.00 A; A/B=1-673 # PIR E65181 HJECDR # PROSITE PS51198 UVRD_HELICASE_ATP_BIND # PROSITE PS51217 UVRD_HELICASE_CTER # Pfam PF00580 UvrD-helicase # Pfam PF13361 UvrD_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ATP-dependent DNA helicase Rep {ECO:0000255|HAMAP-Rule MF_01920} # RefSeq WP_001238899 NZ_LN832404.1 # RefSeq YP_026251 NC_000913.3 # SEQUENCE CAUTION Sequence=CAA28481.1; Type=Frameshift; Positions=620, 657; Evidence={ECO 0000305}; # SIMILARITY Belongs to the helicase family. UvrD subfamily. {ECO:0000255|HAMAP-Rule MF_01920}. # SIMILARITY Contains 1 uvrD-like helicase ATP-binding domain. {ECO:0000255|HAMAP-Rule MF_01920}. # SIMILARITY Contains 1 uvrD-like helicase C-terminal domain. {ECO:0000255|HAMAP-Rule MF_01920}. # SUBUNIT REP_ECOLI Homodimer. {ECO 0000255|HAMAP-Rule MF_01920, ECO 0000269|PubMed 11428893, ECO 0000269|PubMed 1658335}. # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR01074 rep # eggNOG COG0210 LUCA # eggNOG ENOG4105C4R Bacteria BLAST swissprot:REP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:REP_ECOLI BioCyc ECOL316407:JW5604-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5604-MONOMER BioCyc EcoCyc:EG10837-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10837-MONOMER BioCyc MetaCyc:EG10837-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10837-MONOMER COG COG0210 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0210 DIP DIP-10662N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10662N DOI 10.1006/jmbi.2001.4758 http://dx.doi.org/10.1006/jmbi.2001.4758 DOI 10.1016/0022-2836(91)90926-W http://dx.doi.org/10.1016/0022-2836(91)90926-W DOI 10.1016/S0092-8674(00)80525-5 http://dx.doi.org/10.1016/S0092-8674(00)80525-5 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.76.4.1658 http://dx.doi.org/10.1073/pnas.76.4.1658 DOI 10.1093/nar/15.2.465 http://dx.doi.org/10.1093/nar/15.2.465 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.4.12 {ECO:0000255|HAMAP-Rule:MF_01920} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.4.12 {ECO:0000255|HAMAP-Rule:MF_01920} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M11055 http://www.ebi.ac.uk/ena/data/view/M11055 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X04794 http://www.ebi.ac.uk/ena/data/view/X04794 ENZYME 3.6.4.12 {ECO:0000255|HAMAP-Rule:MF_01920} http://enzyme.expasy.org/EC/3.6.4.12 {ECO:0000255|HAMAP-Rule:MF_01920} EchoBASE EB0830 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0830 EcoGene EG10837 http://www.ecogene.org/geneInfo.php?eg_id=EG10837 EnsemblBacteria AAT48209 http://www.ensemblgenomes.org/id/AAT48209 EnsemblBacteria AAT48209 http://www.ensemblgenomes.org/id/AAT48209 EnsemblBacteria BAE77520 http://www.ensemblgenomes.org/id/BAE77520 EnsemblBacteria BAE77520 http://www.ensemblgenomes.org/id/BAE77520 EnsemblBacteria BAE77520 http://www.ensemblgenomes.org/id/BAE77520 EnsemblBacteria b3778 http://www.ensemblgenomes.org/id/b3778 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003697 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003697 GO_function GO:0004003 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004003 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008408 GO_process GO:0006268 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006268 GO_process GO:0044787 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044787 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004386 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0051276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051276 Gene3D 1.10.10.160 http://www.cathdb.info/version/latest/superfamily/1.10.10.160 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948292 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948292 HAMAP MF_01920 http://hamap.expasy.org/unirule/MF_01920 HOGENOM HOG000033015 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000033015&db=HOGENOM6 InParanoid P09980 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P09980 IntAct P09980 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P09980* IntEnz 3.6.4.12 {ECO:0000255|HAMAP-Rule:MF_01920} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.4.12 {ECO:0000255|HAMAP-Rule:MF_01920} InterPro IPR000212 http://www.ebi.ac.uk/interpro/entry/IPR000212 InterPro IPR005752 http://www.ebi.ac.uk/interpro/entry/IPR005752 InterPro IPR013986 http://www.ebi.ac.uk/interpro/entry/IPR013986 InterPro IPR014016 http://www.ebi.ac.uk/interpro/entry/IPR014016 InterPro IPR014017 http://www.ebi.ac.uk/interpro/entry/IPR014017 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW5604 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5604 KEGG_Gene eco:b3778 http://www.genome.jp/dbget-bin/www_bget?eco:b3778 KEGG_Orthology KO:K03656 http://www.genome.jp/dbget-bin/www_bget?KO:K03656 MINT MINT-1286362 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1286362 OMA EKVLMQN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EKVLMQN PANTHER PTHR11070 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11070 PDB 1UAA http://www.ebi.ac.uk/pdbe-srv/view/entry/1UAA PDBsum 1UAA http://www.ebi.ac.uk/pdbsum/1UAA PROSITE PS51198 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51198 PROSITE PS51217 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51217 PSORT swissprot:REP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:REP_ECOLI PSORT-B swissprot:REP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:REP_ECOLI PSORT2 swissprot:REP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:REP_ECOLI Pfam PF00580 http://pfam.xfam.org/family/PF00580 Pfam PF13361 http://pfam.xfam.org/family/PF13361 Phobius swissprot:REP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:REP_ECOLI PhylomeDB P09980 http://phylomedb.org/?seqid=P09980 ProteinModelPortal P09980 http://www.proteinmodelportal.org/query/uniprot/P09980 PubMed 11428893 http://www.ncbi.nlm.nih.gov/pubmed/11428893 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 1658335 http://www.ncbi.nlm.nih.gov/pubmed/1658335 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 221901 http://www.ncbi.nlm.nih.gov/pubmed/221901 PubMed 2999067 http://www.ncbi.nlm.nih.gov/pubmed/2999067 PubMed 3029683 http://www.ncbi.nlm.nih.gov/pubmed/3029683 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9288744 http://www.ncbi.nlm.nih.gov/pubmed/9288744 RefSeq WP_001238899 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001238899 RefSeq YP_026251 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026251 SMR P09980 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P09980 STRING 511145.b3778 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3778&targetmode=cogs STRING COG0210 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0210&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR01074 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01074 UniProtKB REP_ECOLI http://www.uniprot.org/uniprot/REP_ECOLI UniProtKB-AC P09980 http://www.uniprot.org/uniprot/P09980 charge swissprot:REP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:REP_ECOLI eggNOG COG0210 http://eggnogapi.embl.de/nog_data/html/tree/COG0210 eggNOG ENOG4105C4R http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C4R epestfind swissprot:REP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:REP_ECOLI garnier swissprot:REP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:REP_ECOLI helixturnhelix swissprot:REP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:REP_ECOLI hmoment swissprot:REP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:REP_ECOLI iep swissprot:REP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:REP_ECOLI inforesidue swissprot:REP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:REP_ECOLI octanol swissprot:REP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:REP_ECOLI pepcoil swissprot:REP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:REP_ECOLI pepdigest swissprot:REP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:REP_ECOLI pepinfo swissprot:REP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:REP_ECOLI pepnet swissprot:REP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:REP_ECOLI pepstats swissprot:REP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:REP_ECOLI pepwheel swissprot:REP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:REP_ECOLI pepwindow swissprot:REP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:REP_ECOLI sigcleave swissprot:REP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:REP_ECOLI ## Database ID URL or Descriptions # BioGrid 4261284 15 # EcoGene EG12704 yggM # IntAct P46142 2 # InterPro IPR009592 DUF1202 # Organism YGGM_ECOLI Escherichia coli (strain K12) # PATRIC 32121324 VBIEscCol129921_3050 # PIR C65081 C65081 # Pfam PF06717 DUF1202 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGGM_ECOLI Uncharacterized protein YggM # RefSeq NP_417431 NC_000913.3 # RefSeq WP_000745210 NZ_LN832404.1 # eggNOG ENOG4106MH3 Bacteria # eggNOG ENOG410Y9EZ LUCA BLAST swissprot:YGGM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGGM_ECOLI BioCyc ECOL316407:JW2923-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2923-MONOMER BioCyc EcoCyc:EG12704-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12704-MONOMER DOI 10.1016/0378-1119(90)90168-Q http://dx.doi.org/10.1016/0378-1119(90)90168-Q DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M34234 http://www.ebi.ac.uk/ena/data/view/M34234 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2566 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2566 EcoGene EG12704 http://www.ecogene.org/geneInfo.php?eg_id=EG12704 EnsemblBacteria AAC75993 http://www.ensemblgenomes.org/id/AAC75993 EnsemblBacteria AAC75993 http://www.ensemblgenomes.org/id/AAC75993 EnsemblBacteria BAE77019 http://www.ensemblgenomes.org/id/BAE77019 EnsemblBacteria BAE77019 http://www.ensemblgenomes.org/id/BAE77019 EnsemblBacteria BAE77019 http://www.ensemblgenomes.org/id/BAE77019 EnsemblBacteria b2956 http://www.ensemblgenomes.org/id/b2956 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947455 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947455 HOGENOM HOG000124448 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000124448&db=HOGENOM6 IntAct P46142 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P46142* InterPro IPR009592 http://www.ebi.ac.uk/interpro/entry/IPR009592 KEGG_Gene ecj:JW2923 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2923 KEGG_Gene eco:b2956 http://www.genome.jp/dbget-bin/www_bget?eco:b2956 OMA KVTILMK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KVTILMK PSORT swissprot:YGGM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGGM_ECOLI PSORT-B swissprot:YGGM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGGM_ECOLI PSORT2 swissprot:YGGM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGGM_ECOLI Pfam PF06717 http://pfam.xfam.org/family/PF06717 Phobius swissprot:YGGM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGGM_ECOLI ProteinModelPortal P46142 http://www.proteinmodelportal.org/query/uniprot/P46142 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2144836 http://www.ncbi.nlm.nih.gov/pubmed/2144836 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417431 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417431 RefSeq WP_000745210 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000745210 STRING 511145.b2956 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2956&targetmode=cogs UniProtKB YGGM_ECOLI http://www.uniprot.org/uniprot/YGGM_ECOLI UniProtKB-AC P46142 http://www.uniprot.org/uniprot/P46142 charge swissprot:YGGM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGGM_ECOLI eggNOG ENOG4106MH3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106MH3 eggNOG ENOG410Y9EZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y9EZ epestfind swissprot:YGGM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGGM_ECOLI garnier swissprot:YGGM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGGM_ECOLI helixturnhelix swissprot:YGGM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGGM_ECOLI hmoment swissprot:YGGM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGGM_ECOLI iep swissprot:YGGM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGGM_ECOLI inforesidue swissprot:YGGM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGGM_ECOLI octanol swissprot:YGGM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGGM_ECOLI pepcoil swissprot:YGGM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGGM_ECOLI pepdigest swissprot:YGGM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGGM_ECOLI pepinfo swissprot:YGGM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGGM_ECOLI pepnet swissprot:YGGM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGGM_ECOLI pepstats swissprot:YGGM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGGM_ECOLI pepwheel swissprot:YGGM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGGM_ECOLI pepwindow swissprot:YGGM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGGM_ECOLI sigcleave swissprot:YGGM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGGM_ECOLI ## Database ID URL or Descriptions # BioGrid 4261193 214 # EcoGene EG50002 rpmA # GO_component GO:0022625 cytosolic large ribosomal subunit; IDA:EcoCyc. # GO_function GO:0000049 tRNA binding; IEA:UniProtKB-KW. # GO_function GO:0003735 structural constituent of ribosome; IBA:GO_Central. # GO_function GO:0019843 rRNA binding; IEA:UniProtKB-KW. # GO_process GO:0006412 translation; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_function GO:0019843 rRNA binding # GOslim_process GO:0006412 translation # HAMAP MF_00539 Ribosomal_L27 # INTERACTION RL27_ECOLI Q46864 mqsA; NbExp=2; IntAct=EBI-546875, EBI-1120353; # IntAct P0A7L8 26 # InterPro IPR001684 Ribosomal_L27 # InterPro IPR018261 Ribosomal_L27_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=8993.5; Method=MALDI; Range=2-85; Evidence={ECO:0000269|PubMed 10094780}; # Organism RL27_ECOLI Escherichia coli (strain K12) # PANTHER PTHR15893 PTHR15893 # PATRIC 32121790 VBIEscCol129921_3279 # PDB 2J28 EM; 8.00 A; W=2-85 # PDB 2RDO EM; 9.10 A; W=2-85 # PDB 3BBX EM; 10.00 A; W=2-85 # PDB 3J5L EM; 6.60 A; W=7-85 # PDB 3J7Z EM; 3.90 A; W=1-85 # PDB 3J8G EM; 5.00 A; Y=1-85 # PDB 3J9Y EM; 3.90 A; W=1-85 # PDB 3J9Z EM; 3.60 A; LU=2-85 # PDB 3JA1 EM; 3.60 A; LY=2-85 # PDB 3JBU EM; 3.64 A; y=1-85 # PDB 3JBV EM; 3.32 A; y=1-85 # PDB 3JCD EM; 3.70 A; W=1-85 # PDB 3JCE EM; 3.20 A; W=1-85 # PDB 3JCJ EM; 3.70 A; V=1-85 # PDB 3JCN EM; 4.60 A; W=1-85 # PDB 4CSU EM; 5.50 A; Y=2-85 # PDB 4U1U X-ray; 2.95 A; BW/DW=10-85 # PDB 4U1V X-ray; 3.00 A; BW/DW=10-85 # PDB 4U20 X-ray; 2.90 A; BW/DW=10-85 # PDB 4U24 X-ray; 2.90 A; BW/DW=10-85 # PDB 4U25 X-ray; 2.90 A; BW/DW=10-85 # PDB 4U26 X-ray; 2.80 A; BW/DW=10-85 # PDB 4U27 X-ray; 2.80 A; BW/DW=10-85 # PDB 4UY8 EM; 3.80 A; W=7-85 # PDB 4V47 EM; 12.30 A; AU=2-85 # PDB 4V48 EM; 11.50 A; AU=2-85 # PDB 4V4H X-ray; 3.46 A; BW/DW=1-85 # PDB 4V4Q X-ray; 3.46 A; BW/DW=2-85 # PDB 4V4V EM; 15.00 A; BU=2-85 # PDB 4V4W EM; 15.00 A; BU=2-85 # PDB 4V50 X-ray; 3.22 A; BW/DW=2-85 # PDB 4V52 X-ray; 3.21 A; BW/DW=2-85 # PDB 4V53 X-ray; 3.54 A; BW/DW=2-85 # PDB 4V54 X-ray; 3.30 A; BW/DW=2-85 # PDB 4V55 X-ray; 4.00 A; BW/DW=2-85 # PDB 4V56 X-ray; 3.93 A; BW/DW=2-85 # PDB 4V57 X-ray; 3.50 A; BW/DW=2-85 # PDB 4V5B X-ray; 3.74 A; AW/CW=2-85 # PDB 4V5H EM; 5.80 A; BY=7-85 # PDB 4V5Y X-ray; 4.45 A; BW/DW=2-85 # PDB 4V64 X-ray; 3.50 A; BW/DW=2-85 # PDB 4V65 EM; 9.00 A; BP=1-85 # PDB 4V66 EM; 9.00 A; BP=1-85 # PDB 4V69 EM; 6.70 A; BW=7-85 # PDB 4V6C X-ray; 3.19 A; BW/DW=1-85 # PDB 4V6D X-ray; 3.81 A; BW/DW=1-85 # PDB 4V6E X-ray; 3.71 A; BW/DW=1-85 # PDB 4V6K EM; 8.25 A; AX=1-85 # PDB 4V6L EM; 13.20 A; BX=1-85 # PDB 4V6M EM; 7.10 A; BW=2-85 # PDB 4V6N EM; 12.10 A; AY=2-85 # PDB 4V6O EM; 14.70 A; BY=2-85 # PDB 4V6P EM; 13.50 A; BY=2-85 # PDB 4V6Q EM; 11.50 A; BY=2-85 # PDB 4V6R EM; 11.50 A; BY=2-85 # PDB 4V6S EM; 13.10 A; AY=2-85 # PDB 4V6T EM; 8.30 A; BW=10-85 # PDB 4V6V EM; 9.80 A; B0=2-85 # PDB 4V6Y EM; 12.00 A; BW=7-85 # PDB 4V6Z EM; 12.00 A; BW=7-85 # PDB 4V70 EM; 17.00 A; BW=7-85 # PDB 4V71 EM; 20.00 A; BW=7-85 # PDB 4V72 EM; 13.00 A; BW=7-85 # PDB 4V73 EM; 15.00 A; BW=7-85 # PDB 4V74 EM; 17.00 A; BW=7-85 # PDB 4V75 EM; 12.00 A; BW=7-85 # PDB 4V76 EM; 17.00 A; BW=7-85 # PDB 4V77 EM; 17.00 A; BW=7-85 # PDB 4V78 EM; 20.00 A; BW=7-85 # PDB 4V79 EM; 15.00 A; BW=7-85 # PDB 4V7A EM; 9.00 A; BW=7-85 # PDB 4V7B EM; 6.80 A; BW=1-85 # PDB 4V7C EM; 7.60 A; BY=2-85 # PDB 4V7D EM; 7.60 A; AZ=2-85 # PDB 4V7I EM; 9.60 A; AW=1-85 # PDB 4V7S X-ray; 3.25 A; BW/DW=7-85 # PDB 4V7T X-ray; 3.19 A; BW/DW=7-85 # PDB 4V7U X-ray; 3.10 A; BW/DW=7-85 # PDB 4V7V X-ray; 3.29 A; BW/DW=7-85 # PDB 4V85 X-ray; 3.20 A; 0=1-85 # PDB 4V89 X-ray; 3.70 A; B0=1-85 # PDB 4V9C X-ray; 3.30 A; BW/DW=1-85 # PDB 4V9D X-ray; 3.00 A; CW=10-85, DW=11-85 # PDB 4V9O X-ray; 2.90 A; AW/CW/EW/GW=1-85 # PDB 4V9P X-ray; 2.90 A; AW/CW/EW/GW=1-85 # PDB 4WF1 X-ray; 3.09 A; BW/DW=10-85 # PDB 4WOI X-ray; 3.00 A; BW/CW=1-85 # PDB 4WWW X-ray; 3.10 A; RW/YW=7-85 # PDB 4YBB X-ray; 2.10 A; CX/DX=10-85 # PDB 5ADY EM; 4.50 A; W=1-85 # PDB 5AFI EM; 2.90 A; W=1-85 # PDB 5AKA EM; 5.70 A; W=2-85 # PDB 5GAD EM; 3.70 A; X=1-85 # PDB 5GAE EM; 3.33 A; X=1-85 # PDB 5GAF EM; 4.30 A; X=10-85 # PDB 5GAG EM; 3.80 A; X=1-85 # PDB 5GAH EM; 3.80 A; X=1-85 # PDB 5IQR EM; 3.00 A; W=1-85 # PDB 5IT8 X-ray; 3.12 A; CX/DX=10-85 # PDB 5J5B X-ray; 2.80 A; CX/DX=10-85 # PDB 5J7L X-ray; 3.00 A; CX/DX=10-85 # PDB 5J88 X-ray; 3.32 A; CX/DX=10-85 # PDB 5J8A X-ray; 3.10 A; CX/DX=3-85 # PDB 5J91 X-ray; 2.96 A; CX/DX=10-85 # PDB 5JC9 X-ray; 3.03 A; CX/DX=10-85 # PDB 5JTE EM; 3.60 A; BW=1-85 # PDB 5JU8 EM; 3.60 A; BW=1-85 # PDB 5KCR EM; 3.60 A; 10=1-85 # PDB 5KCS EM; 3.90 A; 10=1-85 # PDB 5KPS EM; 3.90 A; W=1-85 # PDB 5KPV EM; 4.10 A; V=1-85 # PDB 5KPW EM; 3.90 A; V=1-85 # PDB 5KPX EM; 3.90 A; V=1-85 # PDB 5L3P EM; 3.70 A; 0=1-85 # PIR JS0767 R5EC27 # PRINTS PR00063 RIBOSOMALL27 # PROSITE PS00831 RIBOSOMAL_L27 # Pfam PF01016 Ribosomal_L27 # ProDom PD003114 Ribosomal_L27 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RL27_ECOLI 50S ribosomal protein L27 # RefSeq NP_417652 NC_000913.3 # RefSeq WP_000940595 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein L27P family. {ECO 0000305}. # SUBUNIT RL27_ECOLI Part of the 50S ribosomal subunit, cross-links to the 23S rRNA. Cross-links to the A and P site tRNAs. {ECO 0000269|PubMed 6170935, ECO 0000269|PubMed 7556101, ECO 0000269|PubMed 8524654}. # TIGRFAMs TIGR00062 L27 # eggNOG COG0211 LUCA # eggNOG ENOG4105K46 Bacteria BLAST swissprot:RL27_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RL27_ECOLI BioCyc ECOL316407:JW3152-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3152-MONOMER BioCyc EcoCyc:EG50002-MONOMER http://biocyc.org/getid?id=EcoCyc:EG50002-MONOMER BioCyc MetaCyc:EG50002-MONOMER http://biocyc.org/getid?id=MetaCyc:EG50002-MONOMER COG COG0211 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0211 DIP DIP-47933N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47933N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1016/0014-5793(75)80349-8 http://dx.doi.org/10.1016/0014-5793(75)80349-8 DOI 10.1016/S0092-8674(03)00427-6 http://dx.doi.org/10.1016/S0092-8674(03)00427-6 DOI 10.1016/j.celrep.2014.09.011 http://dx.doi.org/10.1016/j.celrep.2014.09.011 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.22.4635 http://dx.doi.org/10.1093/nar/23.22.4635 DOI 10.1093/nar/9.17.4285 http://dx.doi.org/10.1093/nar/9.17.4285 DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pbio.1001866 http://dx.doi.org/10.1371/journal.pbio.1001866 DisProt DP00140 http://www.disprot.org/protein.php?id=DP00140 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D13267 http://www.ebi.ac.uk/ena/data/view/D13267 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB4296 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4296 EcoGene EG50002 http://www.ecogene.org/geneInfo.php?eg_id=EG50002 EnsemblBacteria AAC76217 http://www.ensemblgenomes.org/id/AAC76217 EnsemblBacteria AAC76217 http://www.ensemblgenomes.org/id/AAC76217 EnsemblBacteria BAE77229 http://www.ensemblgenomes.org/id/BAE77229 EnsemblBacteria BAE77229 http://www.ensemblgenomes.org/id/BAE77229 EnsemblBacteria BAE77229 http://www.ensemblgenomes.org/id/BAE77229 EnsemblBacteria b3185 http://www.ensemblgenomes.org/id/b3185 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0022625 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022625 GO_function GO:0000049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000049 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GeneID 945190 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945190 HAMAP MF_00539 http://hamap.expasy.org/unirule/MF_00539 HOGENOM HOG000111610 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000111610&db=HOGENOM6 InParanoid P0A7L8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7L8 IntAct P0A7L8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7L8* InterPro IPR001684 http://www.ebi.ac.uk/interpro/entry/IPR001684 InterPro IPR018261 http://www.ebi.ac.uk/interpro/entry/IPR018261 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW3152 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3152 KEGG_Gene eco:b3185 http://www.genome.jp/dbget-bin/www_bget?eco:b3185 KEGG_Orthology KO:K02899 http://www.genome.jp/dbget-bin/www_bget?KO:K02899 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 MINT MINT-1317488 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1317488 OMA NGRNNKK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NGRNNKK PANTHER PTHR15893 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15893 PDB 2J28 http://www.ebi.ac.uk/pdbe-srv/view/entry/2J28 PDB 2RDO http://www.ebi.ac.uk/pdbe-srv/view/entry/2RDO PDB 3BBX http://www.ebi.ac.uk/pdbe-srv/view/entry/3BBX PDB 3J5L http://www.ebi.ac.uk/pdbe-srv/view/entry/3J5L PDB 3J7Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J7Z PDB 3J8G http://www.ebi.ac.uk/pdbe-srv/view/entry/3J8G PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 4CSU http://www.ebi.ac.uk/pdbe-srv/view/entry/4CSU PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4UY8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4UY8 PDB 4V47 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V47 PDB 4V48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V48 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5ADY http://www.ebi.ac.uk/pdbe-srv/view/entry/5ADY PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5AKA http://www.ebi.ac.uk/pdbe-srv/view/entry/5AKA PDB 5GAD http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAD PDB 5GAE http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAE PDB 5GAF http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAF PDB 5GAG http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAG PDB 5GAH http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAH PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 2J28 http://www.ebi.ac.uk/pdbsum/2J28 PDBsum 2RDO http://www.ebi.ac.uk/pdbsum/2RDO PDBsum 3BBX http://www.ebi.ac.uk/pdbsum/3BBX PDBsum 3J5L http://www.ebi.ac.uk/pdbsum/3J5L PDBsum 3J7Z http://www.ebi.ac.uk/pdbsum/3J7Z PDBsum 3J8G http://www.ebi.ac.uk/pdbsum/3J8G PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 4CSU http://www.ebi.ac.uk/pdbsum/4CSU PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4UY8 http://www.ebi.ac.uk/pdbsum/4UY8 PDBsum 4V47 http://www.ebi.ac.uk/pdbsum/4V47 PDBsum 4V48 http://www.ebi.ac.uk/pdbsum/4V48 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5ADY http://www.ebi.ac.uk/pdbsum/5ADY PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5AKA http://www.ebi.ac.uk/pdbsum/5AKA PDBsum 5GAD http://www.ebi.ac.uk/pdbsum/5GAD PDBsum 5GAE http://www.ebi.ac.uk/pdbsum/5GAE PDBsum 5GAF http://www.ebi.ac.uk/pdbsum/5GAF PDBsum 5GAG http://www.ebi.ac.uk/pdbsum/5GAG PDBsum 5GAH http://www.ebi.ac.uk/pdbsum/5GAH PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PRINTS PR00063 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00063 PROSITE PS00831 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00831 PSORT swissprot:RL27_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RL27_ECOLI PSORT-B swissprot:RL27_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RL27_ECOLI PSORT2 swissprot:RL27_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RL27_ECOLI Pfam PF01016 http://pfam.xfam.org/family/PF01016 Phobius swissprot:RL27_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RL27_ECOLI PhylomeDB P0A7L8 http://phylomedb.org/?seqid=P0A7L8 ProteinModelPortal P0A7L8 http://www.proteinmodelportal.org/query/uniprot/P0A7L8 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 1225626 http://www.ncbi.nlm.nih.gov/pubmed/1225626 PubMed 12809609 http://www.ncbi.nlm.nih.gov/pubmed/12809609 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 24844575 http://www.ncbi.nlm.nih.gov/pubmed/24844575 PubMed 25310980 http://www.ncbi.nlm.nih.gov/pubmed/25310980 PubMed 6170935 http://www.ncbi.nlm.nih.gov/pubmed/6170935 PubMed 7556101 http://www.ncbi.nlm.nih.gov/pubmed/7556101 PubMed 8312607 http://www.ncbi.nlm.nih.gov/pubmed/8312607 PubMed 8524654 http://www.ncbi.nlm.nih.gov/pubmed/8524654 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417652 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417652 RefSeq WP_000940595 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000940595 SMR P0A7L8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7L8 STRING 511145.b3185 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3185&targetmode=cogs STRING COG0211 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0211&targetmode=cogs TIGRFAMs TIGR00062 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00062 UniProtKB RL27_ECOLI http://www.uniprot.org/uniprot/RL27_ECOLI UniProtKB-AC P0A7L8 http://www.uniprot.org/uniprot/P0A7L8 charge swissprot:RL27_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RL27_ECOLI eggNOG COG0211 http://eggnogapi.embl.de/nog_data/html/tree/COG0211 eggNOG ENOG4105K46 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K46 epestfind swissprot:RL27_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RL27_ECOLI garnier swissprot:RL27_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RL27_ECOLI helixturnhelix swissprot:RL27_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RL27_ECOLI hmoment swissprot:RL27_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RL27_ECOLI iep swissprot:RL27_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RL27_ECOLI inforesidue swissprot:RL27_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RL27_ECOLI octanol swissprot:RL27_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RL27_ECOLI pepcoil swissprot:RL27_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RL27_ECOLI pepdigest swissprot:RL27_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RL27_ECOLI pepinfo swissprot:RL27_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RL27_ECOLI pepnet swissprot:RL27_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RL27_ECOLI pepstats swissprot:RL27_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RL27_ECOLI pepwheel swissprot:RL27_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RL27_ECOLI pepwindow swissprot:RL27_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RL27_ECOLI sigcleave swissprot:RL27_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RL27_ECOLI ## Database ID URL or Descriptions # BioGrid 4260146 153 # EcoGene EG13428 ompG # FUNCTION OMPG_ECOLI Forms channels functionally larger than those of classical porins. {ECO 0000269|PubMed 11758943}. # FUNCTION OMPG_ECOLI May act as a regulator of the RCS-phosphorelay signal transduction pathway. {ECO 0000269|PubMed 11758943}. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_component GO:0045203 integral component of cell outer membrane; IDA:EcoCyc. # GO_component GO:0046930 pore complex; IEA:UniProtKB-KW. # GO_function GO:0015288 porin activity; IMP:EcoliWiki. # GO_function GO:0015478 oligosaccharide transporting porin activity; IDA:EcoCyc. # GO_function GO:0015481 maltose transporting porin activity; IDA:EcoCyc. # GO_process GO:0006811 ion transport; IEA:UniProtKB-KW. # GO_process GO:0034219 carbohydrate transmembrane transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043234 protein complex # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # InterPro IPR018981 Outer_membrane_protein_G # KEGG_Brite ko02000 Transporters # Organism OMPG_ECOLI Escherichia coli (strain K12) # PATRIC 32117912 VBIEscCol129921_1376 # PDB 2F1C X-ray; 2.30 A; X=22-301 # PDB 2IWV X-ray; 2.30 A; A/B/C/D=22-301 # PDB 2IWW X-ray; 2.70 A; A/B=22-301 # PDB 2JQY NMR; -; A=22-301 # PDB 2WVP X-ray; 2.40 A; A=22-301 # PDB 2X9K X-ray; 2.18 A; A=22-301 # PDB 4CTD X-ray; 3.20 A; A/B=22-301 # PIR B64881 B64881 # Pfam PF09381 Porin_OmpG # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName OMPG_ECOLI Outer membrane protein G # RefSeq NP_415835 NC_000913.3 # RefSeq WP_000735257 NZ_LN832404.1 # SUBCELLULAR LOCATION OMPG_ECOLI Cell outer membrane; Multi-pass membrane protein. # SUBUNIT OMPG_ECOLI Monomer. # TCDB 1.B.21.1 the ompg porin (ompg) family # eggNOG ENOG4107EFV Bacteria # eggNOG ENOG410YHNX LUCA BLAST swissprot:OMPG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:OMPG_ECOLI BioCyc ECOL316407:JW1312-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1312-MONOMER BioCyc EcoCyc:G6657-MONOMER http://biocyc.org/getid?id=EcoCyc:G6657-MONOMER DIP DIP-10399N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10399N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1271/bbb.65.2364 http://dx.doi.org/10.1271/bbb.65.2364 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U49400 http://www.ebi.ac.uk/ena/data/view/U49400 EchoBASE EB3202 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3202 EcoGene EG13428 http://www.ecogene.org/geneInfo.php?eg_id=EG13428 EnsemblBacteria AAC74401 http://www.ensemblgenomes.org/id/AAC74401 EnsemblBacteria AAC74401 http://www.ensemblgenomes.org/id/AAC74401 EnsemblBacteria BAE76401 http://www.ensemblgenomes.org/id/BAE76401 EnsemblBacteria BAE76401 http://www.ensemblgenomes.org/id/BAE76401 EnsemblBacteria BAE76401 http://www.ensemblgenomes.org/id/BAE76401 EnsemblBacteria b1319 http://www.ensemblgenomes.org/id/b1319 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0045203 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045203 GO_component GO:0046930 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046930 GO_function GO:0015288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015288 GO_function GO:0015478 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015478 GO_function GO:0015481 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015481 GO_process GO:0006811 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811 GO_process GO:0034219 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034219 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 945889 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945889 HOGENOM HOG000120098 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120098&db=HOGENOM6 IntAct P76045 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76045* InterPro IPR018981 http://www.ebi.ac.uk/interpro/entry/IPR018981 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1312 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1312 KEGG_Gene eco:b1319 http://www.genome.jp/dbget-bin/www_bget?eco:b1319 KEGG_Orthology KO:K14053 http://www.genome.jp/dbget-bin/www_bget?KO:K14053 MINT MINT-1227757 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1227757 OMA CAQAAEN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CAQAAEN PDB 2F1C http://www.ebi.ac.uk/pdbe-srv/view/entry/2F1C PDB 2IWV http://www.ebi.ac.uk/pdbe-srv/view/entry/2IWV PDB 2IWW http://www.ebi.ac.uk/pdbe-srv/view/entry/2IWW PDB 2JQY http://www.ebi.ac.uk/pdbe-srv/view/entry/2JQY PDB 2WVP http://www.ebi.ac.uk/pdbe-srv/view/entry/2WVP PDB 2X9K http://www.ebi.ac.uk/pdbe-srv/view/entry/2X9K PDB 4CTD http://www.ebi.ac.uk/pdbe-srv/view/entry/4CTD PDBsum 2F1C http://www.ebi.ac.uk/pdbsum/2F1C PDBsum 2IWV http://www.ebi.ac.uk/pdbsum/2IWV PDBsum 2IWW http://www.ebi.ac.uk/pdbsum/2IWW PDBsum 2JQY http://www.ebi.ac.uk/pdbsum/2JQY PDBsum 2WVP http://www.ebi.ac.uk/pdbsum/2WVP PDBsum 2X9K http://www.ebi.ac.uk/pdbsum/2X9K PDBsum 4CTD http://www.ebi.ac.uk/pdbsum/4CTD PSORT swissprot:OMPG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:OMPG_ECOLI PSORT-B swissprot:OMPG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:OMPG_ECOLI PSORT2 swissprot:OMPG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:OMPG_ECOLI Pfam PF09381 http://pfam.xfam.org/family/PF09381 Phobius swissprot:OMPG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:OMPG_ECOLI ProteinModelPortal P76045 http://www.proteinmodelportal.org/query/uniprot/P76045 PubMed 11758943 http://www.ncbi.nlm.nih.gov/pubmed/11758943 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9721282 http://www.ncbi.nlm.nih.gov/pubmed/9721282 RefSeq NP_415835 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415835 RefSeq WP_000735257 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000735257 SMR P76045 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76045 STRING 511145.b1319 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1319&targetmode=cogs TCDB 1.B.21.1 http://www.tcdb.org/search/result.php?tc=1.B.21.1 UniProtKB OMPG_ECOLI http://www.uniprot.org/uniprot/OMPG_ECOLI UniProtKB-AC P76045 http://www.uniprot.org/uniprot/P76045 charge swissprot:OMPG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:OMPG_ECOLI eggNOG ENOG4107EFV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107EFV eggNOG ENOG410YHNX http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YHNX epestfind swissprot:OMPG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:OMPG_ECOLI garnier swissprot:OMPG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:OMPG_ECOLI helixturnhelix swissprot:OMPG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:OMPG_ECOLI hmoment swissprot:OMPG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:OMPG_ECOLI iep swissprot:OMPG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:OMPG_ECOLI inforesidue swissprot:OMPG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:OMPG_ECOLI octanol swissprot:OMPG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:OMPG_ECOLI pepcoil swissprot:OMPG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:OMPG_ECOLI pepdigest swissprot:OMPG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:OMPG_ECOLI pepinfo swissprot:OMPG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:OMPG_ECOLI pepnet swissprot:OMPG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:OMPG_ECOLI pepstats swissprot:OMPG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:OMPG_ECOLI pepwheel swissprot:OMPG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:OMPG_ECOLI pepwindow swissprot:OMPG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:OMPG_ECOLI sigcleave swissprot:OMPG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:OMPG_ECOLI ## Database ID URL or Descriptions # BioGrid 4260369 13 # EcoGene EG14316 yecT # InterPro IPR009739 DUF1311 # Organism YECT_ECOLI Escherichia coli (strain K12) # PATRIC 32119079 VBIEscCol129921_1957 # PIR E64950 E64950 # Pfam PF07007 DUF1311 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YECT_ECOLI Uncharacterized protein YecT # RefSeq NP_416391 NC_000913.3 # RefSeq WP_001299676 NZ_LN832404.1 # SIMILARITY To R.meliloti R02472. {ECO 0000305}. # eggNOG COG3755 LUCA BLAST swissprot:YECT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YECT_ECOLI BioCyc ECOL316407:JW5310-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5310-MONOMER BioCyc EcoCyc:G7026-MONOMER http://biocyc.org/getid?id=EcoCyc:G7026-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4063 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4063 EcoGene EG14316 http://www.ecogene.org/geneInfo.php?eg_id=EG14316 EnsemblBacteria AAC74947 http://www.ensemblgenomes.org/id/AAC74947 EnsemblBacteria AAC74947 http://www.ensemblgenomes.org/id/AAC74947 EnsemblBacteria BAE76549 http://www.ensemblgenomes.org/id/BAE76549 EnsemblBacteria BAE76549 http://www.ensemblgenomes.org/id/BAE76549 EnsemblBacteria BAE76549 http://www.ensemblgenomes.org/id/BAE76549 EnsemblBacteria b1877 http://www.ensemblgenomes.org/id/b1877 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946511 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946511 HOGENOM HOG000009491 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009491&db=HOGENOM6 InterPro IPR009739 http://www.ebi.ac.uk/interpro/entry/IPR009739 KEGG_Gene ecj:JW5310 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5310 KEGG_Gene eco:b1877 http://www.genome.jp/dbget-bin/www_bget?eco:b1877 OMA HNSEDFY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HNSEDFY PSORT swissprot:YECT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YECT_ECOLI PSORT-B swissprot:YECT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YECT_ECOLI PSORT2 swissprot:YECT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YECT_ECOLI Pfam PF07007 http://pfam.xfam.org/family/PF07007 Phobius swissprot:YECT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YECT_ECOLI ProteinModelPortal P76296 http://www.proteinmodelportal.org/query/uniprot/P76296 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416391 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416391 RefSeq WP_001299676 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001299676 SMR P76296 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76296 STRING 511145.b1877 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1877&targetmode=cogs UniProtKB YECT_ECOLI http://www.uniprot.org/uniprot/YECT_ECOLI UniProtKB-AC P76296 http://www.uniprot.org/uniprot/P76296 charge swissprot:YECT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YECT_ECOLI eggNOG COG3755 http://eggnogapi.embl.de/nog_data/html/tree/COG3755 epestfind swissprot:YECT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YECT_ECOLI garnier swissprot:YECT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YECT_ECOLI helixturnhelix swissprot:YECT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YECT_ECOLI hmoment swissprot:YECT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YECT_ECOLI iep swissprot:YECT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YECT_ECOLI inforesidue swissprot:YECT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YECT_ECOLI octanol swissprot:YECT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YECT_ECOLI pepcoil swissprot:YECT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YECT_ECOLI pepdigest swissprot:YECT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YECT_ECOLI pepinfo swissprot:YECT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YECT_ECOLI pepnet swissprot:YECT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YECT_ECOLI pepstats swissprot:YECT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YECT_ECOLI pepwheel swissprot:YECT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YECT_ECOLI pepwindow swissprot:YECT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YECT_ECOLI sigcleave swissprot:YECT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YECT_ECOLI ## Database ID URL or Descriptions # BioGrid 4259729 5 # EcoGene EG11572 thiQ # FUNCTION THIQ_ECOLI Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system (Probable). {ECO 0000305|PubMed 12175925}. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IEA:UniProtKB-HAMAP. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0048502 thiamine-transporting ATPase activity; IEA:UniProtKB-HAMAP. # GO_process GO:0015888 thiamine transport; IEA:UniProtKB-HAMAP. # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # Gene3D 3.40.50.300 -; 1. # IntAct P31548 6 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR005968 Thiamine_ABC_ThiQ # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00191 Thiamine transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism THIQ_ECOLI Escherichia coli (strain K12) # PATRIC 32115233 VBIEscCol129921_0068 # PIR B64728 B64728 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # PROSITE PS51288 THIQ # Pfam PF00005 ABC_tran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Thiamine import ATP-binding protein ThiQ {ECO:0000255|HAMAP-Rule MF_01723} # RefSeq NP_414608 NC_000913.3 # RefSeq WP_000916281 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. Thiamine importer (TC 3.A.1.19.1) family. {ECO:0000255|HAMAP- Rule MF_01723}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|HAMAP- Rule MF_01723}. # SMART SM00382 AAA # SUBCELLULAR LOCATION THIQ_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01723}; Peripheral membrane protein {ECO 0000255|HAMAP- Rule MF_01723}. # SUBUNIT The complex is composed of two ATP-binding proteins (ThiQ), two transmembrane proteins (ThiP) and a solute-binding protein (ThiB). {ECO:0000255|HAMAP-Rule MF_01723}. # SUPFAM SSF52540 SSF52540 # TCDB 3.A.1.19 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR01277 thiQ # eggNOG COG3840 LUCA # eggNOG ENOG4107T0D Bacteria BLAST swissprot:THIQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:THIQ_ECOLI BioCyc ECOL316407:JW0065-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0065-MONOMER BioCyc EcoCyc:SFUC-MONOMER http://biocyc.org/getid?id=EcoCyc:SFUC-MONOMER COG COG3840 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3840 DOI 10.1007/s00239-002-2423-0 http://dx.doi.org/10.1007/s00239-002-2423-0 DOI 10.1016/S0005-2736(02)00477-7 http://dx.doi.org/10.1016/S0005-2736(02)00477-7 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.3.- {ECO:0000255|HAMAP-Rule:MF_01723} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.- {ECO:0000255|HAMAP-Rule:MF_01723} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL AY625120 http://www.ebi.ac.uk/ena/data/view/AY625120 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.6.3.- {ECO:0000255|HAMAP-Rule:MF_01723} http://enzyme.expasy.org/EC/3.6.3.- {ECO:0000255|HAMAP-Rule:MF_01723} EchoBASE EB1532 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1532 EcoGene EG11572 http://www.ecogene.org/geneInfo.php?eg_id=EG11572 EnsemblBacteria AAC73177 http://www.ensemblgenomes.org/id/AAC73177 EnsemblBacteria AAC73177 http://www.ensemblgenomes.org/id/AAC73177 EnsemblBacteria BAB96635 http://www.ensemblgenomes.org/id/BAB96635 EnsemblBacteria BAB96635 http://www.ensemblgenomes.org/id/BAB96635 EnsemblBacteria BAB96635 http://www.ensemblgenomes.org/id/BAB96635 EnsemblBacteria b0066 http://www.ensemblgenomes.org/id/b0066 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0048502 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048502 GO_process GO:0015888 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015888 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 944785 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944785 InParanoid P31548 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31548 IntAct P31548 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31548* IntEnz 3.6.3.- {ECO:0000255|HAMAP-Rule:MF_01723} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.- {ECO:0000255|HAMAP-Rule:MF_01723} InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR005968 http://www.ebi.ac.uk/interpro/entry/IPR005968 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0065 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0065 KEGG_Gene eco:b0066 http://www.genome.jp/dbget-bin/www_bget?eco:b0066 KEGG_Orthology KO:K02062 http://www.genome.jp/dbget-bin/www_bget?KO:K02062 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA ACCLVRE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ACCLVRE PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PROSITE PS51288 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51288 PSORT swissprot:THIQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:THIQ_ECOLI PSORT-B swissprot:THIQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:THIQ_ECOLI PSORT2 swissprot:THIQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:THIQ_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Phobius swissprot:THIQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:THIQ_ECOLI PhylomeDB P31548 http://phylomedb.org/?seqid=P31548 ProteinModelPortal P31548 http://www.proteinmodelportal.org/query/uniprot/P31548 PubMed 12175925 http://www.ncbi.nlm.nih.gov/pubmed/12175925 PubMed 12664169 http://www.ncbi.nlm.nih.gov/pubmed/12664169 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414608 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414608 RefSeq WP_000916281 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000916281 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P31548 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31548 STRING 511145.b0066 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0066&targetmode=cogs STRING COG3840 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3840&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.19 http://www.tcdb.org/search/result.php?tc=3.A.1.19 TIGRFAMs TIGR01277 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01277 UniProtKB THIQ_ECOLI http://www.uniprot.org/uniprot/THIQ_ECOLI UniProtKB-AC P31548 http://www.uniprot.org/uniprot/P31548 charge swissprot:THIQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:THIQ_ECOLI eggNOG COG3840 http://eggnogapi.embl.de/nog_data/html/tree/COG3840 eggNOG ENOG4107T0D http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107T0D epestfind swissprot:THIQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:THIQ_ECOLI garnier swissprot:THIQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:THIQ_ECOLI helixturnhelix swissprot:THIQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:THIQ_ECOLI hmoment swissprot:THIQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:THIQ_ECOLI iep swissprot:THIQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:THIQ_ECOLI inforesidue swissprot:THIQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:THIQ_ECOLI octanol swissprot:THIQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:THIQ_ECOLI pepcoil swissprot:THIQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:THIQ_ECOLI pepdigest swissprot:THIQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:THIQ_ECOLI pepinfo swissprot:THIQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:THIQ_ECOLI pepnet swissprot:THIQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:THIQ_ECOLI pepstats swissprot:THIQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:THIQ_ECOLI pepwheel swissprot:THIQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:THIQ_ECOLI pepwindow swissprot:THIQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:THIQ_ECOLI sigcleave swissprot:THIQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:THIQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4260084 6 # DISRUPTION PHENOTYPE BLUR_ECOLI 3- to 20-fold derepression of several genes coding for small proteins including the ycgZ-ymgA-ariR-ymgC operon. While the BluR/F system is induced at low temperatures under blue light irradiation, it is not essential for growth under these conditions. When both lon and bluR are disrupted, levels of OmpF decrease, leading to lower drug susceptibility, with a greater effect at 26 degrees than at 37 degrees Celsius. The mechanism is not yet understood. {ECO 0000269|PubMed 19240136, ECO 0000269|PubMed 19721064}. # EcoGene EG13886 bluR # FUNCTION BLUR_ECOLI Controls the expression of several small proteins that may play a role in biofilm maturation. Binds to and represses the operator of the ycgZ-ymgA-ariR-ymgC operon and also regulates ynaK. Binding is antagonized by BluF upon blue light (470 nm) irradiation. Blue light may increase the affinity of BluF for BluR, allowing it to be released from its operator. {ECO 0000269|PubMed 19240136, ECO 0000269|PubMed 22783906}. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # INDUCTION Expression is strongly activated (7-fold at 16 degrees Celsius compared to 37 degrees) at low temperature. {ECO:0000269|PubMed 19240136}. # IntAct P75989 39 # InterPro IPR000551 MerR-type_HTH_dom # InterPro IPR009061 DNA-bd_dom_put # Organism BLUR_ECOLI Escherichia coli (strain K12) # PATRIC 32117561 VBIEscCol129921_1203 # PIR G64861 G64861 # PROSITE PS00552 HTH_MERR_1 # PROSITE PS50937 HTH_MERR_2 # Pfam PF13411 MerR_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HTH-type transcriptional repressor BluR {ECO 0000305} # RefSeq NP_415680 NC_000913.3 # RefSeq WP_000332303 NZ_LN832404.1 # SIMILARITY Contains 1 HTH merR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00254}. # SMART SM00422 HTH_MERR # SUBUNIT BLUR_ECOLI Interacts with BluF. {ECO 0000269|PubMed 19240136, ECO 0000269|PubMed 22783906}. # SUPFAM SSF46955 SSF46955 # eggNOG COG0789 LUCA # eggNOG ENOG4108XDN Bacteria BLAST swissprot:BLUR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BLUR_ECOLI BioCyc ECOL316407:JW1149-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1149-MONOMER BioCyc EcoCyc:G6602-MONOMER http://biocyc.org/getid?id=EcoCyc:G6602-MONOMER DIP DIP-11552N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11552N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1101/gad.499409 http://dx.doi.org/10.1101/gad.499409 DOI 10.1111/j.1365-2958.2012.08147.x http://dx.doi.org/10.1111/j.1365-2958.2012.08147.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AAC.00787-09 http://dx.doi.org/10.1128/AAC.00787-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3645 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3645 EcoGene EG13886 http://www.ecogene.org/geneInfo.php?eg_id=EG13886 EnsemblBacteria AAC74246 http://www.ensemblgenomes.org/id/AAC74246 EnsemblBacteria AAC74246 http://www.ensemblgenomes.org/id/AAC74246 EnsemblBacteria BAA35997 http://www.ensemblgenomes.org/id/BAA35997 EnsemblBacteria BAA35997 http://www.ensemblgenomes.org/id/BAA35997 EnsemblBacteria BAA35997 http://www.ensemblgenomes.org/id/BAA35997 EnsemblBacteria b1162 http://www.ensemblgenomes.org/id/b1162 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 945735 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945735 HOGENOM HOG000119656 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000119656&db=HOGENOM6 InParanoid P75989 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75989 IntAct P75989 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75989* InterPro IPR000551 http://www.ebi.ac.uk/interpro/entry/IPR000551 InterPro IPR009061 http://www.ebi.ac.uk/interpro/entry/IPR009061 KEGG_Gene ecj:JW1149 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1149 KEGG_Gene eco:b1162 http://www.genome.jp/dbget-bin/www_bget?eco:b1162 MINT MINT-1244002 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1244002 OMA LLIGWEC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LLIGWEC PROSITE PS00552 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00552 PROSITE PS50937 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50937 PSORT swissprot:BLUR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BLUR_ECOLI PSORT-B swissprot:BLUR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BLUR_ECOLI PSORT2 swissprot:BLUR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BLUR_ECOLI Pfam PF13411 http://pfam.xfam.org/family/PF13411 Phobius swissprot:BLUR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BLUR_ECOLI ProteinModelPortal P75989 http://www.proteinmodelportal.org/query/uniprot/P75989 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19240136 http://www.ncbi.nlm.nih.gov/pubmed/19240136 PubMed 19721064 http://www.ncbi.nlm.nih.gov/pubmed/19721064 PubMed 22783906 http://www.ncbi.nlm.nih.gov/pubmed/22783906 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415680 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415680 RefSeq WP_000332303 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000332303 SMART SM00422 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00422 SMR P75989 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75989 STRING 511145.b1162 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1162&targetmode=cogs SUPFAM SSF46955 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46955 UniProtKB BLUR_ECOLI http://www.uniprot.org/uniprot/BLUR_ECOLI UniProtKB-AC P75989 http://www.uniprot.org/uniprot/P75989 charge swissprot:BLUR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BLUR_ECOLI eggNOG COG0789 http://eggnogapi.embl.de/nog_data/html/tree/COG0789 eggNOG ENOG4108XDN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108XDN epestfind swissprot:BLUR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BLUR_ECOLI garnier swissprot:BLUR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BLUR_ECOLI helixturnhelix swissprot:BLUR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BLUR_ECOLI hmoment swissprot:BLUR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BLUR_ECOLI iep swissprot:BLUR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BLUR_ECOLI inforesidue swissprot:BLUR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BLUR_ECOLI octanol swissprot:BLUR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BLUR_ECOLI pepcoil swissprot:BLUR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BLUR_ECOLI pepdigest swissprot:BLUR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BLUR_ECOLI pepinfo swissprot:BLUR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BLUR_ECOLI pepnet swissprot:BLUR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BLUR_ECOLI pepstats swissprot:BLUR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BLUR_ECOLI pepwheel swissprot:BLUR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BLUR_ECOLI pepwindow swissprot:BLUR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BLUR_ECOLI sigcleave swissprot:BLUR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BLUR_ECOLI ## Database ID URL or Descriptions # EcoGene EG14175 yffN # Organism YFFN_ECOLI Escherichia coli (strain K12) # PIR D65019 D65019 # Proteomes UP000000625 Chromosome # RecName YFFN_ECOLI Uncharacterized protein YffN # RefSeq NP_416940 NC_000913.3 # RefSeq WP_000683389 NZ_CP014272.1 BLAST swissprot:YFFN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFFN_ECOLI BioCyc EcoCyc:G7275-MONOMER http://biocyc.org/getid?id=EcoCyc:G7275-MONOMER DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3927 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3927 EcoGene EG14175 http://www.ecogene.org/geneInfo.php?eg_id=EG14175 EnsemblBacteria AAC75498 http://www.ensemblgenomes.org/id/AAC75498 EnsemblBacteria AAC75498 http://www.ensemblgenomes.org/id/AAC75498 EnsemblBacteria b2445 http://www.ensemblgenomes.org/id/b2445 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946930 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946930 HOGENOM HOG000054851 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000054851&db=HOGENOM6 KEGG_Gene eco:b2445 http://www.genome.jp/dbget-bin/www_bget?eco:b2445 OMA GGIMKHV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GGIMKHV PSORT swissprot:YFFN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFFN_ECOLI PSORT-B swissprot:YFFN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFFN_ECOLI PSORT2 swissprot:YFFN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFFN_ECOLI Phobius swissprot:YFFN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFFN_ECOLI ProteinModelPortal P76545 http://www.proteinmodelportal.org/query/uniprot/P76545 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416940 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416940 RefSeq WP_000683389 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000683389 STRING 511145.b2445 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2445&targetmode=cogs UniProtKB YFFN_ECOLI http://www.uniprot.org/uniprot/YFFN_ECOLI UniProtKB-AC P76545 http://www.uniprot.org/uniprot/P76545 charge swissprot:YFFN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFFN_ECOLI epestfind swissprot:YFFN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFFN_ECOLI garnier swissprot:YFFN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFFN_ECOLI helixturnhelix swissprot:YFFN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFFN_ECOLI hmoment swissprot:YFFN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFFN_ECOLI iep swissprot:YFFN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFFN_ECOLI inforesidue swissprot:YFFN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFFN_ECOLI octanol swissprot:YFFN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFFN_ECOLI pepcoil swissprot:YFFN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFFN_ECOLI pepdigest swissprot:YFFN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFFN_ECOLI pepinfo swissprot:YFFN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFFN_ECOLI pepnet swissprot:YFFN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFFN_ECOLI pepstats swissprot:YFFN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFFN_ECOLI pepwheel swissprot:YFFN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFFN_ECOLI pepwindow swissprot:YFFN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFFN_ECOLI sigcleave swissprot:YFFN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFFN_ECOLI ## Database ID URL or Descriptions # BioGrid 4263451 230 # EcoGene EG11917 yjaH # InterPro IPR010858 DUF1481 # InterPro IPR012640 Membr_lipoprot_lipid_attach_CS # InterPro IPR016500 UCP006993 # Organism YJAH_ECOLI Escherichia coli (strain K12) # PATRIC 32123525 VBIEscCol129921_4115 # PIR D65207 D65207 # PIRSF PIRSF006993 UCP006993 # Pfam PF07356 DUF1481 # Pfam PF08139 LPAM_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJAH_ECOLI Uncharacterized protein YjaH # RefSeq NP_418429 NC_000913.3 # RefSeq WP_001084037 NZ_LN832404.1 # eggNOG ENOG4108T8B Bacteria # eggNOG ENOG4111HZZ LUCA BLAST swissprot:YJAH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJAH_ECOLI BioCyc ECOL316407:JW3965-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3965-MONOMER BioCyc EcoCyc:EG11917-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11917-MONOMER DIP DIP-12529N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12529N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1861 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1861 EcoGene EG11917 http://www.ecogene.org/geneInfo.php?eg_id=EG11917 EnsemblBacteria AAC76975 http://www.ensemblgenomes.org/id/AAC76975 EnsemblBacteria AAC76975 http://www.ensemblgenomes.org/id/AAC76975 EnsemblBacteria BAE77318 http://www.ensemblgenomes.org/id/BAE77318 EnsemblBacteria BAE77318 http://www.ensemblgenomes.org/id/BAE77318 EnsemblBacteria BAE77318 http://www.ensemblgenomes.org/id/BAE77318 EnsemblBacteria b4001 http://www.ensemblgenomes.org/id/b4001 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 948508 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948508 HOGENOM HOG000126775 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126775&db=HOGENOM6 IntAct P32681 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32681* InterPro IPR010858 http://www.ebi.ac.uk/interpro/entry/IPR010858 InterPro IPR012640 http://www.ebi.ac.uk/interpro/entry/IPR012640 InterPro IPR016500 http://www.ebi.ac.uk/interpro/entry/IPR016500 KEGG_Gene ecj:JW3965 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3965 KEGG_Gene eco:b4001 http://www.genome.jp/dbget-bin/www_bget?eco:b4001 MINT MINT-1305643 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1305643 OMA FMQREVD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FMQREVD PSORT swissprot:YJAH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJAH_ECOLI PSORT-B swissprot:YJAH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJAH_ECOLI PSORT2 swissprot:YJAH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJAH_ECOLI Pfam PF07356 http://pfam.xfam.org/family/PF07356 Pfam PF08139 http://pfam.xfam.org/family/PF08139 Phobius swissprot:YJAH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJAH_ECOLI ProteinModelPortal P32681 http://www.proteinmodelportal.org/query/uniprot/P32681 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418429 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418429 RefSeq WP_001084037 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001084037 STRING 511145.b4001 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4001&targetmode=cogs UniProtKB YJAH_ECOLI http://www.uniprot.org/uniprot/YJAH_ECOLI UniProtKB-AC P32681 http://www.uniprot.org/uniprot/P32681 charge swissprot:YJAH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJAH_ECOLI eggNOG ENOG4108T8B http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108T8B eggNOG ENOG4111HZZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111HZZ epestfind swissprot:YJAH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJAH_ECOLI garnier swissprot:YJAH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJAH_ECOLI helixturnhelix swissprot:YJAH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJAH_ECOLI hmoment swissprot:YJAH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJAH_ECOLI iep swissprot:YJAH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJAH_ECOLI inforesidue swissprot:YJAH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJAH_ECOLI octanol swissprot:YJAH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJAH_ECOLI pepcoil swissprot:YJAH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJAH_ECOLI pepdigest swissprot:YJAH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJAH_ECOLI pepinfo swissprot:YJAH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJAH_ECOLI pepnet swissprot:YJAH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJAH_ECOLI pepstats swissprot:YJAH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJAH_ECOLI pepwheel swissprot:YJAH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJAH_ECOLI pepwindow swissprot:YJAH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJAH_ECOLI sigcleave swissprot:YJAH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJAH_ECOLI ## Database ID URL or Descriptions # BioGrid 4259152 15 # EcoGene EG13504 yeaR # Gene3D 2.60.120.10 -; 1. # IntAct P64488 7 # InterPro IPR014510 Tellurite-R_YeaR # InterPro IPR014710 RmlC-like_jellyroll # InterPro IPR015392 DUF1971 # Organism YEAR_ECOLI Escherichia coli (strain K12) # PATRIC 32118909 VBIEscCol129921_1872 # PDB 3BB6 X-ray; 2.30 A; A/B/C/D=1-119 # PIR E64940 E64940 # PIRSF PIRSF020632 YeaR # Pfam PF09313 DUF1971 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEAR_ECOLI Uncharacterized protein YeaR # RefSeq NP_416311 NC_000913.3 # RefSeq WP_000939317 NZ_LN832404.1 # eggNOG COG3615 LUCA # eggNOG ENOG4108YS1 Bacteria BLAST swissprot:YEAR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEAR_ECOLI BioCyc ECOL316407:JW1786-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1786-MONOMER BioCyc EcoCyc:G6983-MONOMER http://biocyc.org/getid?id=EcoCyc:G6983-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3277 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3277 EcoGene EG13504 http://www.ecogene.org/geneInfo.php?eg_id=EG13504 EnsemblBacteria AAC74867 http://www.ensemblgenomes.org/id/AAC74867 EnsemblBacteria AAC74867 http://www.ensemblgenomes.org/id/AAC74867 EnsemblBacteria BAE76533 http://www.ensemblgenomes.org/id/BAE76533 EnsemblBacteria BAE76533 http://www.ensemblgenomes.org/id/BAE76533 EnsemblBacteria BAE76533 http://www.ensemblgenomes.org/id/BAE76533 EnsemblBacteria b1797 http://www.ensemblgenomes.org/id/b1797 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 2.60.120.10 http://www.cathdb.info/version/latest/superfamily/2.60.120.10 GeneID 946317 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946317 HOGENOM HOG000269651 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000269651&db=HOGENOM6 InParanoid P64488 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P64488 IntAct P64488 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P64488* InterPro IPR014510 http://www.ebi.ac.uk/interpro/entry/IPR014510 InterPro IPR014710 http://www.ebi.ac.uk/interpro/entry/IPR014710 InterPro IPR015392 http://www.ebi.ac.uk/interpro/entry/IPR015392 KEGG_Gene ecj:JW1786 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1786 KEGG_Gene eco:b1797 http://www.genome.jp/dbget-bin/www_bget?eco:b1797 OMA GAIRYYG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GAIRYYG PDB 3BB6 http://www.ebi.ac.uk/pdbe-srv/view/entry/3BB6 PDBsum 3BB6 http://www.ebi.ac.uk/pdbsum/3BB6 PSORT swissprot:YEAR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEAR_ECOLI PSORT-B swissprot:YEAR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEAR_ECOLI PSORT2 swissprot:YEAR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEAR_ECOLI Pfam PF09313 http://pfam.xfam.org/family/PF09313 Phobius swissprot:YEAR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEAR_ECOLI ProteinModelPortal P64488 http://www.proteinmodelportal.org/query/uniprot/P64488 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416311 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416311 RefSeq WP_000939317 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000939317 SMR P64488 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P64488 STRING 511145.b1797 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1797&targetmode=cogs UniProtKB YEAR_ECOLI http://www.uniprot.org/uniprot/YEAR_ECOLI UniProtKB-AC P64488 http://www.uniprot.org/uniprot/P64488 charge swissprot:YEAR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEAR_ECOLI eggNOG COG3615 http://eggnogapi.embl.de/nog_data/html/tree/COG3615 eggNOG ENOG4108YS1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108YS1 epestfind swissprot:YEAR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEAR_ECOLI garnier swissprot:YEAR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEAR_ECOLI helixturnhelix swissprot:YEAR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEAR_ECOLI hmoment swissprot:YEAR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEAR_ECOLI iep swissprot:YEAR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEAR_ECOLI inforesidue swissprot:YEAR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEAR_ECOLI octanol swissprot:YEAR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEAR_ECOLI pepcoil swissprot:YEAR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEAR_ECOLI pepdigest swissprot:YEAR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEAR_ECOLI pepinfo swissprot:YEAR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEAR_ECOLI pepnet swissprot:YEAR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEAR_ECOLI pepstats swissprot:YEAR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEAR_ECOLI pepwheel swissprot:YEAR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEAR_ECOLI pepwindow swissprot:YEAR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEAR_ECOLI sigcleave swissprot:YEAR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEAR_ECOLI ## Database ID URL or Descriptions # BioGrid 4261553 9 # CDD cd06259 YdcF-like # EcoGene EG12110 ydcF # FUNCTION YDCF_ECOLI Binds S-adenosyl-L-methionine (AdoMet). # Gene3D 3.40.50.620 -; 1. # IntAct P34209 2 # InterPro IPR003848 DUF218 # InterPro IPR014729 Rossmann-like_a/b/a_fold # Organism YDCF_ECOLI Escherichia coli (strain K12) # PATRIC 32118114 VBIEscCol129921_1477 # PDB 3CA8 X-ray; 1.80 A; A/B=1-266 # PIR A64893 A64893 # Pfam PF02698 DUF218 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDCF_ECOLI Protein YdcF # RefSeq NP_415932 NC_000913.3 # RefSeq WP_001027942 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA24246.1; Type=Frameshift; Positions=8, 23; Evidence={ECO 0000305}; # SIMILARITY To S.coelicolor SCO4629. {ECO 0000305}. # SUBUNIT Monomer. {ECO:0000269|PubMed 18393394}. # eggNOG COG1434 LUCA # eggNOG ENOG4107DB1 Bacteria BLAST swissprot:YDCF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDCF_ECOLI BioCyc ECOL316407:JW1411-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1411-MONOMER BioCyc EcoCyc:EG12110-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12110-MONOMER DIP DIP-11642N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11642N DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1002/prot.22046 http://dx.doi.org/10.1002/prot.22046 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L09068 http://www.ebi.ac.uk/ena/data/view/L09068 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2033 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2033 EcoGene EG12110 http://www.ecogene.org/geneInfo.php?eg_id=EG12110 EnsemblBacteria AAC74496 http://www.ensemblgenomes.org/id/AAC74496 EnsemblBacteria AAC74496 http://www.ensemblgenomes.org/id/AAC74496 EnsemblBacteria BAA15030 http://www.ensemblgenomes.org/id/BAA15030 EnsemblBacteria BAA15030 http://www.ensemblgenomes.org/id/BAA15030 EnsemblBacteria BAA15030 http://www.ensemblgenomes.org/id/BAA15030 EnsemblBacteria b1414 http://www.ensemblgenomes.org/id/b1414 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 GeneID 946215 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946215 HOGENOM HOG000120552 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120552&db=HOGENOM6 InParanoid P34209 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P34209 IntAct P34209 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P34209* InterPro IPR003848 http://www.ebi.ac.uk/interpro/entry/IPR003848 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 KEGG_Gene ecj:JW1411 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1411 KEGG_Gene eco:b1414 http://www.genome.jp/dbget-bin/www_bget?eco:b1414 OMA ILCQDAT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ILCQDAT PDB 3CA8 http://www.ebi.ac.uk/pdbe-srv/view/entry/3CA8 PDBsum 3CA8 http://www.ebi.ac.uk/pdbsum/3CA8 PSORT swissprot:YDCF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDCF_ECOLI PSORT-B swissprot:YDCF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDCF_ECOLI PSORT2 swissprot:YDCF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDCF_ECOLI Pfam PF02698 http://pfam.xfam.org/family/PF02698 Phobius swissprot:YDCF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDCF_ECOLI PhylomeDB P34209 http://phylomedb.org/?seqid=P34209 ProteinModelPortal P34209 http://www.proteinmodelportal.org/query/uniprot/P34209 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18393394 http://www.ncbi.nlm.nih.gov/pubmed/18393394 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415932 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415932 RefSeq WP_001027942 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001027942 SMR P34209 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P34209 STRING 511145.b1414 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1414&targetmode=cogs UniProtKB YDCF_ECOLI http://www.uniprot.org/uniprot/YDCF_ECOLI UniProtKB-AC P34209 http://www.uniprot.org/uniprot/P34209 charge swissprot:YDCF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDCF_ECOLI eggNOG COG1434 http://eggnogapi.embl.de/nog_data/html/tree/COG1434 eggNOG ENOG4107DB1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107DB1 epestfind swissprot:YDCF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDCF_ECOLI garnier swissprot:YDCF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDCF_ECOLI helixturnhelix swissprot:YDCF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDCF_ECOLI hmoment swissprot:YDCF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDCF_ECOLI iep swissprot:YDCF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDCF_ECOLI inforesidue swissprot:YDCF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDCF_ECOLI octanol swissprot:YDCF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDCF_ECOLI pepcoil swissprot:YDCF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDCF_ECOLI pepdigest swissprot:YDCF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDCF_ECOLI pepinfo swissprot:YDCF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDCF_ECOLI pepnet swissprot:YDCF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDCF_ECOLI pepstats swissprot:YDCF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDCF_ECOLI pepwheel swissprot:YDCF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDCF_ECOLI pepwindow swissprot:YDCF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDCF_ECOLI sigcleave swissprot:YDCF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDCF_ECOLI ## Database ID URL or Descriptions # AltName AK1H_ECOLI Aspartokinase I/homoserine dehydrogenase I # BioGrid 4261933 229 # CATALYTIC ACTIVITY AK1H_ECOLI ATP + L-aspartate = ADP + 4-phospho-L- aspartate. # CATALYTIC ACTIVITY AK1H_ECOLI L-homoserine + NAD(P)(+) = L-aspartate 4- semialdehyde + NAD(P)H. # ENZYME REGULATION AK1H_ECOLI The enzyme activities are regulated allosterically by L-threonine. # EcoGene EG10998 thrA # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0004072 aspartate kinase activity; IDA:EcoCyc. # GO_function GO:0004412 homoserine dehydrogenase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016597 amino acid binding; IEA:InterPro. # GO_function GO:0050661 NADP binding; IEA:InterPro. # GO_process GO:0009088 threonine biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0009089 lysine biosynthetic process via diaminopimelate; IDA:EcoCyc. # GO_process GO:0009090 homoserine biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.1160.10 -; 2. # Gene3D 3.40.50.720 -; 1. # IntAct P00561 7 # InterPro IPR001048 Asp/Glu/Uridylate_kinase # InterPro IPR001341 Asp_kinase_dom # InterPro IPR001342 HDH_cat # InterPro IPR002912 ACT_dom # InterPro IPR005106 Asp/hSer_DH_NAD-bd # InterPro IPR011147 Bifunc_aspartokin/hSer_DH # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR018042 Aspartate_kinase_CS # InterPro IPR019811 HDH_CS # InterPro IPR027795 GATS-like_ACT_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00260 Glycine, serine and threonine metabolism # KEGG_Pathway ko00270 Cysteine and methionine metabolism # KEGG_Pathway ko00300 Lysine biosynthesis # MISCELLANEOUS AK1H_ECOLI Aspartokinase II-homoserine dehydrogenase II and aspartokinase III also catalyze the same reaction(s). # Organism AK1H_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate step 1/4. # PATHWAY Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate step 1/3. # PATHWAY Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate step 3/3. # PATHWAY Amino-acid biosynthesis; L-threonine biosynthesis; L- threonine from L-aspartate step 1/5. # PATHWAY Amino-acid biosynthesis; L-threonine biosynthesis; L- threonine from L-aspartate step 3/5. # PATRIC 32115099 VBIEscCol129921_0001 # PIR B64720 DEECK # PIRSF PIRSF000727 ThrA # PROSITE PS00324 ASPARTOKINASE # PROSITE PS01042 HOMOSER_DHGENASE # PROSITE PS51671 ACT; 2 # Pfam PF00696 AA_kinase # Pfam PF00742 Homoserine_dh # Pfam PF01842 ACT # Pfam PF03447 NAD_binding_3 # Pfam PF13840 ACT_7 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AK1H_ECOLI Aspartokinase # RecName AK1H_ECOLI Bifunctional aspartokinase/homoserine dehydrogenase 1 # RecName AK1H_ECOLI Homoserine dehydrogenase # RefSeq NP_414543 NC_000913.3 # RefSeq WP_001264707 NZ_LN832404.1 # SIMILARITY Contains 2 ACT domains. {ECO:0000255|PROSITE- ProRule PRU01007}. # SIMILARITY In the C-terminal section; belongs to the homoserine dehydrogenase family. {ECO 0000305}. # SIMILARITY In the N-terminal section; belongs to the aspartokinase family. {ECO 0000305}. # SUBUNIT AK1H_ECOLI Homotetramer. # SUPFAM SSF51735 SSF51735 # SUPFAM SSF53633 SSF53633 # TIGRFAMs TIGR00657 asp_kinases # UniPathway UPA00034 UER00015 # UniPathway UPA00050 UER00063 # UniPathway UPA00050 UER00461 # UniPathway UPA00051 UER00462 # UniPathway UPA00051 UER00465 # eggNOG COG0460 LUCA # eggNOG COG0527 LUCA # eggNOG ENOG4105CFH Bacteria BLAST swissprot:AK1H_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AK1H_ECOLI BioCyc ECOL316407:JW0001-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0001-MONOMER BioCyc EcoCyc:ASPKINIHOMOSERDEHYDROGI-MONOMER http://biocyc.org/getid?id=EcoCyc:ASPKINIHOMOSERDEHYDROGI-MONOMER BioCyc MetaCyc:ASPKINIHOMOSERDEHYDROGI-MONOMER http://biocyc.org/getid?id=MetaCyc:ASPKINIHOMOSERDEHYDROGI-MONOMER COG COG0460 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0460 COG COG0527 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0527 DIP DIP-2907N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-2907N DOI 10.1007/BF00267853 http://dx.doi.org/10.1007/BF00267853 DOI 10.1016/0022-2836(85)90169-X http://dx.doi.org/10.1016/0022-2836(85)90169-X DOI 10.1016/S0300-9084(79)80174-1 http://dx.doi.org/10.1016/S0300-9084(79)80174-1 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.77.10.5730 http://dx.doi.org/10.1073/pnas.77.10.5730 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.3 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.3 EC_number EC:2.7.2.4 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.2.4 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01706 http://www.ebi.ac.uk/ena/data/view/J01706 EMBL M10644 http://www.ebi.ac.uk/ena/data/view/M10644 EMBL M28570 http://www.ebi.ac.uk/ena/data/view/M28570 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL V00360 http://www.ebi.ac.uk/ena/data/view/V00360 EMBL V00361 http://www.ebi.ac.uk/ena/data/view/V00361 EMBL X68872 http://www.ebi.ac.uk/ena/data/view/X68872 ENZYME 1.1.1.3 http://enzyme.expasy.org/EC/1.1.1.3 ENZYME 2.7.2.4 http://enzyme.expasy.org/EC/2.7.2.4 EchoBASE EB0991 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0991 EcoGene EG10998 http://www.ecogene.org/geneInfo.php?eg_id=EG10998 EnsemblBacteria AAC73113 http://www.ensemblgenomes.org/id/AAC73113 EnsemblBacteria AAC73113 http://www.ensemblgenomes.org/id/AAC73113 EnsemblBacteria BAB96579 http://www.ensemblgenomes.org/id/BAB96579 EnsemblBacteria BAB96579 http://www.ensemblgenomes.org/id/BAB96579 EnsemblBacteria BAB96579 http://www.ensemblgenomes.org/id/BAB96579 EnsemblBacteria b0002 http://www.ensemblgenomes.org/id/b0002 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004072 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004072 GO_function GO:0004412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004412 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016597 GO_function GO:0050661 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050661 GO_process GO:0009088 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009088 GO_process GO:0009089 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009089 GO_process GO:0009090 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009090 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.1160.10 http://www.cathdb.info/version/latest/superfamily/3.40.1160.10 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 945803 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945803 HOGENOM HOG000271593 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000271593&db=HOGENOM6 InParanoid P00561 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00561 IntAct P00561 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00561* IntEnz 1.1.1.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.3 IntEnz 2.7.2.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.2.4 InterPro IPR001048 http://www.ebi.ac.uk/interpro/entry/IPR001048 InterPro IPR001341 http://www.ebi.ac.uk/interpro/entry/IPR001341 InterPro IPR001342 http://www.ebi.ac.uk/interpro/entry/IPR001342 InterPro IPR002912 http://www.ebi.ac.uk/interpro/entry/IPR002912 InterPro IPR005106 http://www.ebi.ac.uk/interpro/entry/IPR005106 InterPro IPR011147 http://www.ebi.ac.uk/interpro/entry/IPR011147 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR018042 http://www.ebi.ac.uk/interpro/entry/IPR018042 InterPro IPR019811 http://www.ebi.ac.uk/interpro/entry/IPR019811 InterPro IPR027795 http://www.ebi.ac.uk/interpro/entry/IPR027795 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0001 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0001 KEGG_Gene eco:b0002 http://www.genome.jp/dbget-bin/www_bget?eco:b0002 KEGG_Orthology KO:K12524 http://www.genome.jp/dbget-bin/www_bget?KO:K12524 KEGG_Pathway ko00260 http://www.genome.jp/kegg-bin/show_pathway?ko00260 KEGG_Pathway ko00270 http://www.genome.jp/kegg-bin/show_pathway?ko00270 KEGG_Pathway ko00300 http://www.genome.jp/kegg-bin/show_pathway?ko00300 KEGG_Reaction rn:R00480 http://www.genome.jp/dbget-bin/www_bget?rn:R00480 KEGG_Reaction rn:R01773 http://www.genome.jp/dbget-bin/www_bget?rn:R01773 KEGG_Reaction rn:R01775 http://www.genome.jp/dbget-bin/www_bget?rn:R01775 MINT MINT-1288804 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1288804 OMA QAYDESS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QAYDESS PROSITE PS00324 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00324 PROSITE PS01042 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01042 PROSITE PS51671 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51671 PSORT swissprot:AK1H_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AK1H_ECOLI PSORT-B swissprot:AK1H_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AK1H_ECOLI PSORT2 swissprot:AK1H_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AK1H_ECOLI Pfam PF00696 http://pfam.xfam.org/family/PF00696 Pfam PF00742 http://pfam.xfam.org/family/PF00742 Pfam PF01842 http://pfam.xfam.org/family/PF01842 Pfam PF03447 http://pfam.xfam.org/family/PF03447 Pfam PF13840 http://pfam.xfam.org/family/PF13840 Phobius swissprot:AK1H_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AK1H_ECOLI PhylomeDB P00561 http://phylomedb.org/?seqid=P00561 ProteinModelPortal P00561 http://www.proteinmodelportal.org/query/uniprot/P00561 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2410621 http://www.ncbi.nlm.nih.gov/pubmed/2410621 PubMed 387092 http://www.ncbi.nlm.nih.gov/pubmed/387092 PubMed 390305 http://www.ncbi.nlm.nih.gov/pubmed/390305 PubMed 6277952 http://www.ncbi.nlm.nih.gov/pubmed/6277952 PubMed 6298218 http://www.ncbi.nlm.nih.gov/pubmed/6298218 PubMed 7003595 http://www.ncbi.nlm.nih.gov/pubmed/7003595 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414543 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414543 RefSeq WP_001264707 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001264707 SMR P00561 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00561 STRING 511145.b0002 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0002&targetmode=cogs STRING COG0460 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0460&targetmode=cogs STRING COG0527 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0527&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 SUPFAM SSF53633 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53633 TIGRFAMs TIGR00657 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00657 UniProtKB AK1H_ECOLI http://www.uniprot.org/uniprot/AK1H_ECOLI UniProtKB-AC P00561 http://www.uniprot.org/uniprot/P00561 charge swissprot:AK1H_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AK1H_ECOLI eggNOG COG0460 http://eggnogapi.embl.de/nog_data/html/tree/COG0460 eggNOG COG0527 http://eggnogapi.embl.de/nog_data/html/tree/COG0527 eggNOG ENOG4105CFH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CFH epestfind swissprot:AK1H_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AK1H_ECOLI garnier swissprot:AK1H_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AK1H_ECOLI helixturnhelix swissprot:AK1H_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AK1H_ECOLI hmoment swissprot:AK1H_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AK1H_ECOLI iep swissprot:AK1H_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AK1H_ECOLI inforesidue swissprot:AK1H_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AK1H_ECOLI octanol swissprot:AK1H_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AK1H_ECOLI pepcoil swissprot:AK1H_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AK1H_ECOLI pepdigest swissprot:AK1H_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AK1H_ECOLI pepinfo swissprot:AK1H_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AK1H_ECOLI pepnet swissprot:AK1H_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AK1H_ECOLI pepstats swissprot:AK1H_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AK1H_ECOLI pepwheel swissprot:AK1H_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AK1H_ECOLI pepwindow swissprot:AK1H_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AK1H_ECOLI sigcleave swissprot:AK1H_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AK1H_ECOLI ## Database ID URL or Descriptions # BioGrid 4261979 8 # EcoGene EG12466 yjdI # IntAct P0AF59 5 # InterPro IPR010693 Divergent_4Fe-4S_mono-cluster # Organism YJDI_ECOLI Escherichia coli (strain K12) # PATRIC 32123817 VBIEscCol129921_4257 # PIR S56355 S56355 # Pfam PF06902 Fer4_19 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJDI_ECOLI Uncharacterized protein YjdI # RefSeq NP_418550 NC_000913.3 # RefSeq WP_000371704 NZ_LN832404.1 # eggNOG COG3592 LUCA # eggNOG ENOG4105VR1 Bacteria BLAST swissprot:YJDI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJDI_ECOLI BioCyc ECOL316407:JW4087-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4087-MONOMER BioCyc EcoCyc:G7828-MONOMER http://biocyc.org/getid?id=EcoCyc:G7828-MONOMER DIP DIP-48210N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48210N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2359 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2359 EcoGene EG12466 http://www.ecogene.org/geneInfo.php?eg_id=EG12466 EnsemblBacteria AAC77087 http://www.ensemblgenomes.org/id/AAC77087 EnsemblBacteria AAC77087 http://www.ensemblgenomes.org/id/AAC77087 EnsemblBacteria BAE78128 http://www.ensemblgenomes.org/id/BAE78128 EnsemblBacteria BAE78128 http://www.ensemblgenomes.org/id/BAE78128 EnsemblBacteria BAE78128 http://www.ensemblgenomes.org/id/BAE78128 EnsemblBacteria b4126 http://www.ensemblgenomes.org/id/b4126 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 948648 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948648 HOGENOM HOG000165757 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000165757&db=HOGENOM6 InParanoid P0AF59 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AF59 IntAct P0AF59 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AF59* InterPro IPR010693 http://www.ebi.ac.uk/interpro/entry/IPR010693 KEGG_Gene ecj:JW4087 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4087 KEGG_Gene eco:b4126 http://www.genome.jp/dbget-bin/www_bget?eco:b4126 OMA YFNTNVC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YFNTNVC PSORT swissprot:YJDI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJDI_ECOLI PSORT-B swissprot:YJDI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJDI_ECOLI PSORT2 swissprot:YJDI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJDI_ECOLI Pfam PF06902 http://pfam.xfam.org/family/PF06902 Phobius swissprot:YJDI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJDI_ECOLI ProteinModelPortal P0AF59 http://www.proteinmodelportal.org/query/uniprot/P0AF59 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418550 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418550 RefSeq WP_000371704 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000371704 STRING 511145.b4126 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4126&targetmode=cogs UniProtKB YJDI_ECOLI http://www.uniprot.org/uniprot/YJDI_ECOLI UniProtKB-AC P0AF59 http://www.uniprot.org/uniprot/P0AF59 charge swissprot:YJDI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJDI_ECOLI eggNOG COG3592 http://eggnogapi.embl.de/nog_data/html/tree/COG3592 eggNOG ENOG4105VR1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VR1 epestfind swissprot:YJDI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJDI_ECOLI garnier swissprot:YJDI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJDI_ECOLI helixturnhelix swissprot:YJDI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJDI_ECOLI hmoment swissprot:YJDI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJDI_ECOLI iep swissprot:YJDI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJDI_ECOLI inforesidue swissprot:YJDI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJDI_ECOLI octanol swissprot:YJDI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJDI_ECOLI pepcoil swissprot:YJDI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJDI_ECOLI pepdigest swissprot:YJDI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJDI_ECOLI pepinfo swissprot:YJDI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJDI_ECOLI pepnet swissprot:YJDI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJDI_ECOLI pepstats swissprot:YJDI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJDI_ECOLI pepwheel swissprot:YJDI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJDI_ECOLI pepwindow swissprot:YJDI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJDI_ECOLI sigcleave swissprot:YJDI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJDI_ECOLI ## Database ID URL or Descriptions # AltName TRUD_ECOLI tRNA pseudouridine(13) synthase # AltName TRUD_ECOLI tRNA pseudouridylate synthase D # AltName TRUD_ECOLI tRNA-uridine isomerase D # BRENDA 5.4.99.27 2026 # BioGrid 4262278 7 # CATALYTIC ACTIVITY TRUD_ECOLI tRNA uridine(13) = tRNA pseudouridine(13). {ECO 0000269|PubMed 12756329, ECO 0000269|PubMed 19664587}. # EcoGene EG13109 truD # FUNCTION TRUD_ECOLI Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs. {ECO 0000269|PubMed 12756329}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003723 RNA binding; IEA:InterPro. # GO_function GO:0009982 pseudouridine synthase activity; IDA:EcoCyc. # GO_process GO:0001522 pseudouridine synthesis; IDA:EcoCyc. # GO_process GO:0031119 tRNA pseudouridine synthesis; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # HAMAP MF_01082 TruD # IntAct Q57261 9 # InterPro IPR001656 PsdUridine_synth_TruD # InterPro IPR011760 PsdUridine_synth_TruD_insert # InterPro IPR020103 PsdUridine_synth_cat_dom # InterPro IPR020119 PsdUridine_synth_TruD_CS # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # Organism TRUD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR13326 PTHR13326 # PATRIC 32120896 VBIEscCol129921_2840 # PDB 1SB7 X-ray; 2.20 A; A/B=1-349 # PDB 1SI7 X-ray; 2.20 A; A=1-349 # PDB 1SZW X-ray; 2.00 A; A/B=1-349 # PIR I69731 I69731 # PROSITE PS01268 UPF0024 # PROSITE PS50984 TRUD # Pfam PF01142 TruD; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TRUD_ECOLI tRNA pseudouridine synthase D # RefSeq NP_417225 NC_000913.3 # RefSeq WP_000568943 NZ_LN832404.1 # SIMILARITY Belongs to the pseudouridine synthase TruD family. {ECO 0000305}. # SIMILARITY Contains 1 TRUD domain. {ECO 0000305}. # SUBUNIT Monomer. {ECO:0000305|PubMed 15039583}. # SUPFAM SSF55120 SSF55120 # TIGRFAMs TIGR00094 tRNA_TruD_broad # eggNOG COG0585 LUCA # eggNOG ENOG4106NZV Bacteria BLAST swissprot:TRUD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRUD_ECOLI BioCyc ECOL316407:JW2715-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2715-MONOMER BioCyc EcoCyc:G7422-MONOMER http://biocyc.org/getid?id=EcoCyc:G7422-MONOMER BioCyc MetaCyc:G7422-MONOMER http://biocyc.org/getid?id=MetaCyc:G7422-MONOMER COG COG0585 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0585 DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1016/j.abb.2009.07.023 http://dx.doi.org/10.1016/j.abb.2009.07.023 DOI 10.1016/j.febslet.2004.03.085 http://dx.doi.org/10.1016/j.febslet.2004.03.085 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.C400072200 http://dx.doi.org/10.1074/jbc.C400072200 DOI 10.1107/S0907444904003506 http://dx.doi.org/10.1107/S0907444904003506 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1261/rna.5230603 http://dx.doi.org/10.1261/rna.5230603 DOI 10.1261/rna.7240504 http://dx.doi.org/10.1261/rna.7240504 EC_number EC:5.4.99.27 http://www.genome.jp/dbget-bin/www_bget?EC:5.4.99.27 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L07942 http://www.ebi.ac.uk/ena/data/view/L07942 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 ENZYME 5.4.99.27 http://enzyme.expasy.org/EC/5.4.99.27 EchoBASE EB2912 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2912 EcoGene EG13109 http://www.ecogene.org/geneInfo.php?eg_id=EG13109 EnsemblBacteria AAC75787 http://www.ensemblgenomes.org/id/AAC75787 EnsemblBacteria AAC75787 http://www.ensemblgenomes.org/id/AAC75787 EnsemblBacteria BAE76822 http://www.ensemblgenomes.org/id/BAE76822 EnsemblBacteria BAE76822 http://www.ensemblgenomes.org/id/BAE76822 EnsemblBacteria BAE76822 http://www.ensemblgenomes.org/id/BAE76822 EnsemblBacteria b2745 http://www.ensemblgenomes.org/id/b2745 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0009982 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009982 GO_process GO:0001522 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001522 GO_process GO:0031119 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031119 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 947214 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947214 HAMAP MF_01082 http://hamap.expasy.org/unirule/MF_01082 HOGENOM HOG000224848 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000224848&db=HOGENOM6 InParanoid Q57261 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q57261 IntAct Q57261 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q57261* IntEnz 5.4.99.27 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.4.99.27 InterPro IPR001656 http://www.ebi.ac.uk/interpro/entry/IPR001656 InterPro IPR011760 http://www.ebi.ac.uk/interpro/entry/IPR011760 InterPro IPR020103 http://www.ebi.ac.uk/interpro/entry/IPR020103 InterPro IPR020119 http://www.ebi.ac.uk/interpro/entry/IPR020119 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW2715 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2715 KEGG_Gene eco:b2745 http://www.genome.jp/dbget-bin/www_bget?eco:b2745 KEGG_Orthology KO:K06176 http://www.genome.jp/dbget-bin/www_bget?KO:K06176 OMA LWLWVEK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LWLWVEK PANTHER PTHR13326 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13326 PDB 1SB7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1SB7 PDB 1SI7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1SI7 PDB 1SZW http://www.ebi.ac.uk/pdbe-srv/view/entry/1SZW PDBsum 1SB7 http://www.ebi.ac.uk/pdbsum/1SB7 PDBsum 1SI7 http://www.ebi.ac.uk/pdbsum/1SI7 PDBsum 1SZW http://www.ebi.ac.uk/pdbsum/1SZW PROSITE PS01268 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01268 PROSITE PS50984 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50984 PSORT swissprot:TRUD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRUD_ECOLI PSORT-B swissprot:TRUD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRUD_ECOLI PSORT2 swissprot:TRUD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRUD_ECOLI Pfam PF01142 http://pfam.xfam.org/family/PF01142 Phobius swissprot:TRUD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRUD_ECOLI PhylomeDB Q57261 http://phylomedb.org/?seqid=Q57261 ProteinModelPortal Q57261 http://www.proteinmodelportal.org/query/uniprot/Q57261 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 12756329 http://www.ncbi.nlm.nih.gov/pubmed/12756329 PubMed 14999002 http://www.ncbi.nlm.nih.gov/pubmed/14999002 PubMed 15039583 http://www.ncbi.nlm.nih.gov/pubmed/15039583 PubMed 15135053 http://www.ncbi.nlm.nih.gov/pubmed/15135053 PubMed 15208439 http://www.ncbi.nlm.nih.gov/pubmed/15208439 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19664587 http://www.ncbi.nlm.nih.gov/pubmed/19664587 PubMed 7928962 http://www.ncbi.nlm.nih.gov/pubmed/7928962 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417225 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417225 RefSeq WP_000568943 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000568943 SMR Q57261 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q57261 STRING 511145.b2745 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2745&targetmode=cogs STRING COG0585 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0585&targetmode=cogs SUPFAM SSF55120 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55120 TIGRFAMs TIGR00094 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00094 UniProtKB TRUD_ECOLI http://www.uniprot.org/uniprot/TRUD_ECOLI UniProtKB-AC Q57261 http://www.uniprot.org/uniprot/Q57261 charge swissprot:TRUD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRUD_ECOLI eggNOG COG0585 http://eggnogapi.embl.de/nog_data/html/tree/COG0585 eggNOG ENOG4106NZV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106NZV epestfind swissprot:TRUD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRUD_ECOLI garnier swissprot:TRUD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRUD_ECOLI helixturnhelix swissprot:TRUD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRUD_ECOLI hmoment swissprot:TRUD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRUD_ECOLI iep swissprot:TRUD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRUD_ECOLI inforesidue swissprot:TRUD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRUD_ECOLI octanol swissprot:TRUD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRUD_ECOLI pepcoil swissprot:TRUD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRUD_ECOLI pepdigest swissprot:TRUD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRUD_ECOLI pepinfo swissprot:TRUD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRUD_ECOLI pepnet swissprot:TRUD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRUD_ECOLI pepstats swissprot:TRUD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRUD_ECOLI pepwheel swissprot:TRUD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRUD_ECOLI pepwindow swissprot:TRUD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRUD_ECOLI sigcleave swissprot:TRUD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRUD_ECOLI ## Database ID URL or Descriptions # Organism TRBJ_ECOLI Escherichia coli (strain K12) # PIR F32238 QQEC25 # RecName TRBJ_ECOLI Protein TrbJ # RefSeq NP_061475 NC_002483.1 # RefSeq NP_862941 NC_004998.1 # RefSeq WP_001443031 NC_002483.1 # SEQUENCE CAUTION Sequence=AAC44212.1; Type=Erroneous initiation; Evidence={ECO 0000305}; BLAST swissprot:TRBJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRBJ_ECOLI EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL M20787 http://www.ebi.ac.uk/ena/data/view/M20787 EMBL U01159 http://www.ebi.ac.uk/ena/data/view/U01159 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1263554 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263554 GeneID 1446504 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1446504 OMA WIPFCRC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WIPFCRC PSORT swissprot:TRBJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRBJ_ECOLI PSORT-B swissprot:TRBJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRBJ_ECOLI PSORT2 swissprot:TRBJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRBJ_ECOLI Phobius swissprot:TRBJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRBJ_ECOLI ProteinModelPortal P18353 http://www.proteinmodelportal.org/query/uniprot/P18353 PubMed 2536655 http://www.ncbi.nlm.nih.gov/pubmed/2536655 PubMed 7915817 http://www.ncbi.nlm.nih.gov/pubmed/7915817 RefSeq NP_061475 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061475 RefSeq NP_862941 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_862941 RefSeq WP_001443031 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001443031 UniProtKB TRBJ_ECOLI http://www.uniprot.org/uniprot/TRBJ_ECOLI UniProtKB-AC P18353 http://www.uniprot.org/uniprot/P18353 charge swissprot:TRBJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRBJ_ECOLI epestfind swissprot:TRBJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRBJ_ECOLI garnier swissprot:TRBJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRBJ_ECOLI helixturnhelix swissprot:TRBJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRBJ_ECOLI hmoment swissprot:TRBJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRBJ_ECOLI iep swissprot:TRBJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRBJ_ECOLI inforesidue swissprot:TRBJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRBJ_ECOLI octanol swissprot:TRBJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRBJ_ECOLI pepcoil swissprot:TRBJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRBJ_ECOLI pepdigest swissprot:TRBJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRBJ_ECOLI pepinfo swissprot:TRBJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRBJ_ECOLI pepnet swissprot:TRBJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRBJ_ECOLI pepstats swissprot:TRBJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRBJ_ECOLI pepwheel swissprot:TRBJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRBJ_ECOLI pepwindow swissprot:TRBJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRBJ_ECOLI sigcleave swissprot:TRBJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRBJ_ECOLI ## Database ID URL or Descriptions # BRENDA 3.1.3 2026 # BioGrid 4259827 31 # CATALYTIC ACTIVITY A phosphate monoester + H(2)O = an alcohol + phosphate. {ECO:0000255|PROSITE-ProRule PRU10042}. # CDD cd00016 alkPPc # COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI 18420; Note=Binds 1 Mg(2+) ion.; # COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI 29105; Note=Binds 2 Zn(2+) ions.; # EcoGene EG10727 phoA # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_component GO:0042597 periplasmic space; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0004035 alkaline phosphatase activity; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_function GO:0030613 oxidoreductase activity, acting on phosphorus or arsenic in donors; IDA:EcoliWiki. # GO_function GO:0033748 hydrogenase (acceptor) activity; IDA:EcoCyc. # GO_process GO:0016311 dephosphorylation; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # Gene3D 3.40.720.10 -; 1. # INTERACTION PPB_ECOLI P0AEG4 dsbA; NbExp=2; IntAct=EBI-552958, EBI-549711; Q5S007 LRRK2 (xeno); NbExp=2; IntAct=EBI-552958, EBI-5323863; # IntAct P00634 5 # InterPro IPR001952 Alkaline_phosphatase # InterPro IPR017849 Alkaline_Pase-like_a/b/a # InterPro IPR017850 Alkaline_phosphatase_core # InterPro IPR018299 Alkaline_phosphatase_AS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00627 Aminobenzoate degradation # KEGG_Pathway ko00790 Folate biosynthesis # KEGG_Pathway ko02020 Two-component system # Organism PPB_ECOLI Escherichia coli (strain K12) # PATRIC 32115907 VBIEscCol129921_0395 # PDB 1AJA X-ray; 2.50 A; A/B=23-471 # PDB 1AJB X-ray; 2.50 A; A/B=23-471 # PDB 1AJC X-ray; 2.50 A; A/B=23-471 # PDB 1AJD X-ray; 2.50 A; A/B=23-471 # PDB 1ALH X-ray; 2.50 A; A/B=26-471 # PDB 1ALI X-ray; 2.20 A; A/B=23-471 # PDB 1ALJ X-ray; 2.60 A; A/B=23-471 # PDB 1ALK X-ray; 2.00 A; A/B=23-471 # PDB 1ANI X-ray; 2.50 A; A/B=26-471 # PDB 1ANJ X-ray; 2.30 A; A/B=26-471 # PDB 1B8J X-ray; 1.90 A; A/B=23-471 # PDB 1ED8 X-ray; 1.75 A; A/B=23-471 # PDB 1ED9 X-ray; 1.75 A; A/B=23-471 # PDB 1ELX X-ray; 2.60 A; A/B=23-471 # PDB 1ELY X-ray; 2.80 A; A/B=23-471 # PDB 1ELZ X-ray; 2.80 A; A/B=23-471 # PDB 1EW8 X-ray; 2.20 A; A/B=23-471 # PDB 1EW9 X-ray; 2.00 A; A/B=23-471 # PDB 1HJK X-ray; 2.30 A; A/B=23-471 # PDB 1HQA X-ray; 2.25 A; A/B=23-471 # PDB 1KH4 X-ray; 2.40 A; A/B=23-471 # PDB 1KH5 X-ray; 2.00 A; A/B=23-471 # PDB 1KH7 X-ray; 2.40 A; A/B=23-471 # PDB 1KH9 X-ray; 2.50 A; A/B=23-471 # PDB 1KHJ X-ray; 2.30 A; A/B=23-471 # PDB 1KHK X-ray; 2.50 A; A/B=23-471 # PDB 1KHL X-ray; 2.50 A; A/B=23-471 # PDB 1KHN X-ray; 2.60 A; A/B=23-471 # PDB 1URA X-ray; 2.04 A; A/B=26-471 # PDB 1URB X-ray; 2.14 A; A/B=26-471 # PDB 1Y6V X-ray; 1.60 A; A/B=23-471 # PDB 1Y7A X-ray; 1.77 A; A/B=23-471 # PDB 2ANH X-ray; 2.40 A; A/B=26-471 # PDB 2G9Y X-ray; 2.00 A; A/B=23-471 # PDB 2GA3 X-ray; 2.20 A; A/B=23-471 # PDB 2MLX NMR; -; B=220-310 # PDB 2MLY NMR; -; B=1-150 # PDB 2MLZ NMR; -; B=360-471 # PDB 3BDF X-ray; 1.40 A; A/B=22-471 # PDB 3BDG X-ray; 1.40 A; A/B=22-471 # PDB 3BDH X-ray; 1.85 A; A/B=22-471 # PDB 3CMR X-ray; 2.05 A; A/B=23-471 # PDB 3DPC X-ray; 2.30 A; A/B=23-471 # PDB 3DYC X-ray; 2.30 A; A/B=23-471 # PDB 3TG0 X-ray; 1.20 A; A/B/C/D=23-471 # PDB 4KM4 X-ray; 2.80 A; A/B=26-470 # PDB 4YR1 X-ray; 2.24 A; A/B=31-471 # PDB 5C66 X-ray; 2.03 A; A/B=23-471 # PDB 5GAD EM; 3.70 A; k=1-18 # PDB 5GAF EM; 4.30 A; k=1-18 # PDB 5GAG EM; 3.80 A; k=1-18 # PDB 5GAH EM; 3.80 A; k=1-18 # PDB 5JTL NMR; -; E=1-471 # PDB 5JTM NMR; -; E/F/G/H=1-25 # PDB 5JTN NMR; -; E/F=91-145 # PDB 5JTO NMR; -; E/F/G/H=271-310 # PDB 5JTP NMR; -; E/F/G/H=450-471 # PIR A00776 PAECA # PRINTS PR00113 ALKPHPHTASE # PROSITE PS00123 ALKALINE_PHOSPHATASE # Pfam PF00245 Alk_phosphatase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PPB_ECOLI Alkaline phosphatase # RefSeq NP_414917 NC_000913.3 # RefSeq WP_000814403 NZ_LN832404.1 # SIMILARITY Belongs to the alkaline phosphatase family. {ECO 0000305}. # SMART SM00098 alkPPc # SUBCELLULAR LOCATION PPB_ECOLI Periplasm. # SUBUNIT PPB_ECOLI Isozymes 1 and 3 are a dimer of identical chains, isozyme 2 is a dimer of heterogeneous chains, one of each of the subunits from isozymes 1 and 3. # SUPFAM SSF53649 SSF53649 # eggNOG COG1785 LUCA # eggNOG ENOG4105G6Z Bacteria BLAST swissprot:PPB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PPB_ECOLI BioCyc ECOL316407:JW0374-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0374-MONOMER BioCyc EcoCyc:ALKAPHOSPHA-MONOMER http://biocyc.org/getid?id=EcoCyc:ALKAPHOSPHA-MONOMER BioCyc MetaCyc:ALKAPHOSPHA-MONOMER http://biocyc.org/getid?id=MetaCyc:ALKAPHOSPHA-MONOMER COG COG1785 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1785 DIP DIP-10496N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10496N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/jmbi.1998.1635 http://dx.doi.org/10.1006/jmbi.1998.1635 DOI 10.1016/0022-2836(85)90115-9 http://dx.doi.org/10.1016/0022-2836(85)90115-9 DOI 10.1016/0022-2836(91)90724-K http://dx.doi.org/10.1016/0022-2836(91)90724-K DOI 10.1016/0378-1119(85)90319-1 http://dx.doi.org/10.1016/0378-1119(85)90319-1 DOI 10.1016/0378-1119(86)90050-8 http://dx.doi.org/10.1016/0378-1119(86)90050-8 DOI 10.1021/bi00043a001 http://dx.doi.org/10.1021/bi00043a001 DOI 10.1021/bi9523421 http://dx.doi.org/10.1021/bi9523421 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb0897-618 http://dx.doi.org/10.1038/nsb0897-618 DOI 10.1073/pnas.78.6.3473 http://dx.doi.org/10.1073/pnas.78.6.3473 DOI 10.1073/pnas.85.18.7036 http://dx.doi.org/10.1073/pnas.85.18.7036 DOI 10.1074/jbc.274.13.8351 http://dx.doi.org/10.1074/jbc.274.13.8351 DOI 10.1093/nar/14.21.8689 http://dx.doi.org/10.1093/nar/14.21.8689 DOI 10.1093/nar/9.21.5671 http://dx.doi.org/10.1093/nar/9.21.5671 DOI 10.1126/science.1250494 http://dx.doi.org/10.1126/science.1250494 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.3.1 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01659 http://www.ebi.ac.uk/ena/data/view/J01659 EMBL J01660 http://www.ebi.ac.uk/ena/data/view/J01660 EMBL J01661 http://www.ebi.ac.uk/ena/data/view/J01661 EMBL J05005 http://www.ebi.ac.uk/ena/data/view/J05005 EMBL M13345 http://www.ebi.ac.uk/ena/data/view/M13345 EMBL M13763 http://www.ebi.ac.uk/ena/data/view/M13763 EMBL M14399 http://www.ebi.ac.uk/ena/data/view/M14399 EMBL M29664 http://www.ebi.ac.uk/ena/data/view/M29664 EMBL M29665 http://www.ebi.ac.uk/ena/data/view/M29665 EMBL M33536 http://www.ebi.ac.uk/ena/data/view/M33536 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EMBL X04586 http://www.ebi.ac.uk/ena/data/view/X04586 ENZYME 3.1.3.1 http://enzyme.expasy.org/EC/3.1.3.1 EchoBASE EB0720 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0720 EcoGene EG10727 http://www.ecogene.org/geneInfo.php?eg_id=EG10727 EnsemblBacteria AAC73486 http://www.ensemblgenomes.org/id/AAC73486 EnsemblBacteria AAC73486 http://www.ensemblgenomes.org/id/AAC73486 EnsemblBacteria BAE76164 http://www.ensemblgenomes.org/id/BAE76164 EnsemblBacteria BAE76164 http://www.ensemblgenomes.org/id/BAE76164 EnsemblBacteria BAE76164 http://www.ensemblgenomes.org/id/BAE76164 EnsemblBacteria b0383 http://www.ensemblgenomes.org/id/b0383 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0004035 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004035 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0030613 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030613 GO_function GO:0033748 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033748 GO_process GO:0016311 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016311 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.720.10 http://www.cathdb.info/version/latest/superfamily/3.40.720.10 GeneID 945041 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945041 HOGENOM HOG000099117 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000099117&db=HOGENOM6 InParanoid P00634 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00634 IntAct P00634 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00634* IntEnz 3.1.3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.1 InterPro IPR001952 http://www.ebi.ac.uk/interpro/entry/IPR001952 InterPro IPR017849 http://www.ebi.ac.uk/interpro/entry/IPR017849 InterPro IPR017850 http://www.ebi.ac.uk/interpro/entry/IPR017850 InterPro IPR018299 http://www.ebi.ac.uk/interpro/entry/IPR018299 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0374 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0374 KEGG_Gene eco:b0383 http://www.genome.jp/dbget-bin/www_bget?eco:b0383 KEGG_Orthology KO:K01077 http://www.genome.jp/dbget-bin/www_bget?KO:K01077 KEGG_Pathway ko00627 http://www.genome.jp/kegg-bin/show_pathway?ko00627 KEGG_Pathway ko00790 http://www.genome.jp/kegg-bin/show_pathway?ko00790 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 KEGG_Reaction rn:R03024 http://www.genome.jp/dbget-bin/www_bget?rn:R03024 KEGG_Reaction rn:R04620 http://www.genome.jp/dbget-bin/www_bget?rn:R04620 MINT MINT-1283619 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1283619 OMA DITAWEY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DITAWEY PDB 1AJA http://www.ebi.ac.uk/pdbe-srv/view/entry/1AJA PDB 1AJB http://www.ebi.ac.uk/pdbe-srv/view/entry/1AJB PDB 1AJC http://www.ebi.ac.uk/pdbe-srv/view/entry/1AJC PDB 1AJD http://www.ebi.ac.uk/pdbe-srv/view/entry/1AJD PDB 1ALH http://www.ebi.ac.uk/pdbe-srv/view/entry/1ALH PDB 1ALI http://www.ebi.ac.uk/pdbe-srv/view/entry/1ALI PDB 1ALJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1ALJ PDB 1ALK http://www.ebi.ac.uk/pdbe-srv/view/entry/1ALK PDB 1ANI http://www.ebi.ac.uk/pdbe-srv/view/entry/1ANI PDB 1ANJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1ANJ PDB 1B8J http://www.ebi.ac.uk/pdbe-srv/view/entry/1B8J PDB 1ED8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ED8 PDB 1ED9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ED9 PDB 1ELX http://www.ebi.ac.uk/pdbe-srv/view/entry/1ELX PDB 1ELY http://www.ebi.ac.uk/pdbe-srv/view/entry/1ELY PDB 1ELZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1ELZ PDB 1EW8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1EW8 PDB 1EW9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1EW9 PDB 1HJK http://www.ebi.ac.uk/pdbe-srv/view/entry/1HJK PDB 1HQA http://www.ebi.ac.uk/pdbe-srv/view/entry/1HQA PDB 1KH4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1KH4 PDB 1KH5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1KH5 PDB 1KH7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1KH7 PDB 1KH9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1KH9 PDB 1KHJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1KHJ PDB 1KHK http://www.ebi.ac.uk/pdbe-srv/view/entry/1KHK PDB 1KHL http://www.ebi.ac.uk/pdbe-srv/view/entry/1KHL PDB 1KHN http://www.ebi.ac.uk/pdbe-srv/view/entry/1KHN PDB 1URA http://www.ebi.ac.uk/pdbe-srv/view/entry/1URA PDB 1URB http://www.ebi.ac.uk/pdbe-srv/view/entry/1URB PDB 1Y6V http://www.ebi.ac.uk/pdbe-srv/view/entry/1Y6V PDB 1Y7A http://www.ebi.ac.uk/pdbe-srv/view/entry/1Y7A PDB 2ANH http://www.ebi.ac.uk/pdbe-srv/view/entry/2ANH PDB 2G9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/2G9Y PDB 2GA3 http://www.ebi.ac.uk/pdbe-srv/view/entry/2GA3 PDB 2MLX http://www.ebi.ac.uk/pdbe-srv/view/entry/2MLX PDB 2MLY http://www.ebi.ac.uk/pdbe-srv/view/entry/2MLY PDB 2MLZ http://www.ebi.ac.uk/pdbe-srv/view/entry/2MLZ PDB 3BDF http://www.ebi.ac.uk/pdbe-srv/view/entry/3BDF PDB 3BDG http://www.ebi.ac.uk/pdbe-srv/view/entry/3BDG PDB 3BDH http://www.ebi.ac.uk/pdbe-srv/view/entry/3BDH PDB 3CMR http://www.ebi.ac.uk/pdbe-srv/view/entry/3CMR PDB 3DPC http://www.ebi.ac.uk/pdbe-srv/view/entry/3DPC PDB 3DYC http://www.ebi.ac.uk/pdbe-srv/view/entry/3DYC PDB 3TG0 http://www.ebi.ac.uk/pdbe-srv/view/entry/3TG0 PDB 4KM4 http://www.ebi.ac.uk/pdbe-srv/view/entry/4KM4 PDB 4YR1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4YR1 PDB 5C66 http://www.ebi.ac.uk/pdbe-srv/view/entry/5C66 PDB 5GAD http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAD PDB 5GAF http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAF PDB 5GAG http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAG PDB 5GAH http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAH PDB 5JTL http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTL PDB 5JTM http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTM PDB 5JTN http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTN PDB 5JTO http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTO PDB 5JTP http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTP PDBsum 1AJA http://www.ebi.ac.uk/pdbsum/1AJA PDBsum 1AJB http://www.ebi.ac.uk/pdbsum/1AJB PDBsum 1AJC http://www.ebi.ac.uk/pdbsum/1AJC PDBsum 1AJD http://www.ebi.ac.uk/pdbsum/1AJD PDBsum 1ALH http://www.ebi.ac.uk/pdbsum/1ALH PDBsum 1ALI http://www.ebi.ac.uk/pdbsum/1ALI PDBsum 1ALJ http://www.ebi.ac.uk/pdbsum/1ALJ PDBsum 1ALK http://www.ebi.ac.uk/pdbsum/1ALK PDBsum 1ANI http://www.ebi.ac.uk/pdbsum/1ANI PDBsum 1ANJ http://www.ebi.ac.uk/pdbsum/1ANJ PDBsum 1B8J http://www.ebi.ac.uk/pdbsum/1B8J PDBsum 1ED8 http://www.ebi.ac.uk/pdbsum/1ED8 PDBsum 1ED9 http://www.ebi.ac.uk/pdbsum/1ED9 PDBsum 1ELX http://www.ebi.ac.uk/pdbsum/1ELX PDBsum 1ELY http://www.ebi.ac.uk/pdbsum/1ELY PDBsum 1ELZ http://www.ebi.ac.uk/pdbsum/1ELZ PDBsum 1EW8 http://www.ebi.ac.uk/pdbsum/1EW8 PDBsum 1EW9 http://www.ebi.ac.uk/pdbsum/1EW9 PDBsum 1HJK http://www.ebi.ac.uk/pdbsum/1HJK PDBsum 1HQA http://www.ebi.ac.uk/pdbsum/1HQA PDBsum 1KH4 http://www.ebi.ac.uk/pdbsum/1KH4 PDBsum 1KH5 http://www.ebi.ac.uk/pdbsum/1KH5 PDBsum 1KH7 http://www.ebi.ac.uk/pdbsum/1KH7 PDBsum 1KH9 http://www.ebi.ac.uk/pdbsum/1KH9 PDBsum 1KHJ http://www.ebi.ac.uk/pdbsum/1KHJ PDBsum 1KHK http://www.ebi.ac.uk/pdbsum/1KHK PDBsum 1KHL http://www.ebi.ac.uk/pdbsum/1KHL PDBsum 1KHN http://www.ebi.ac.uk/pdbsum/1KHN PDBsum 1URA http://www.ebi.ac.uk/pdbsum/1URA PDBsum 1URB http://www.ebi.ac.uk/pdbsum/1URB PDBsum 1Y6V http://www.ebi.ac.uk/pdbsum/1Y6V PDBsum 1Y7A http://www.ebi.ac.uk/pdbsum/1Y7A PDBsum 2ANH http://www.ebi.ac.uk/pdbsum/2ANH PDBsum 2G9Y http://www.ebi.ac.uk/pdbsum/2G9Y PDBsum 2GA3 http://www.ebi.ac.uk/pdbsum/2GA3 PDBsum 2MLX http://www.ebi.ac.uk/pdbsum/2MLX PDBsum 2MLY http://www.ebi.ac.uk/pdbsum/2MLY PDBsum 2MLZ http://www.ebi.ac.uk/pdbsum/2MLZ PDBsum 3BDF http://www.ebi.ac.uk/pdbsum/3BDF PDBsum 3BDG http://www.ebi.ac.uk/pdbsum/3BDG PDBsum 3BDH http://www.ebi.ac.uk/pdbsum/3BDH PDBsum 3CMR http://www.ebi.ac.uk/pdbsum/3CMR PDBsum 3DPC http://www.ebi.ac.uk/pdbsum/3DPC PDBsum 3DYC http://www.ebi.ac.uk/pdbsum/3DYC PDBsum 3TG0 http://www.ebi.ac.uk/pdbsum/3TG0 PDBsum 4KM4 http://www.ebi.ac.uk/pdbsum/4KM4 PDBsum 4YR1 http://www.ebi.ac.uk/pdbsum/4YR1 PDBsum 5C66 http://www.ebi.ac.uk/pdbsum/5C66 PDBsum 5GAD http://www.ebi.ac.uk/pdbsum/5GAD PDBsum 5GAF http://www.ebi.ac.uk/pdbsum/5GAF PDBsum 5GAG http://www.ebi.ac.uk/pdbsum/5GAG PDBsum 5GAH http://www.ebi.ac.uk/pdbsum/5GAH PDBsum 5JTL http://www.ebi.ac.uk/pdbsum/5JTL PDBsum 5JTM http://www.ebi.ac.uk/pdbsum/5JTM PDBsum 5JTN http://www.ebi.ac.uk/pdbsum/5JTN PDBsum 5JTO http://www.ebi.ac.uk/pdbsum/5JTO PDBsum 5JTP http://www.ebi.ac.uk/pdbsum/5JTP PRINTS PR00113 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00113 PROSITE PS00123 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00123 PSORT swissprot:PPB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PPB_ECOLI PSORT-B swissprot:PPB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PPB_ECOLI PSORT2 swissprot:PPB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PPB_ECOLI Pfam PF00245 http://pfam.xfam.org/family/PF00245 Phobius swissprot:PPB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PPB_ECOLI PhylomeDB P00634 http://phylomedb.org/?seqid=P00634 ProteinModelPortal P00634 http://www.proteinmodelportal.org/query/uniprot/P00634 PubMed 10085061 http://www.ncbi.nlm.nih.gov/pubmed/10085061 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2010919 http://www.ncbi.nlm.nih.gov/pubmed/2010919 PubMed 2345142 http://www.ncbi.nlm.nih.gov/pubmed/2345142 PubMed 24812405 http://www.ncbi.nlm.nih.gov/pubmed/24812405 PubMed 2668291 http://www.ncbi.nlm.nih.gov/pubmed/2668291 PubMed 3045828 http://www.ncbi.nlm.nih.gov/pubmed/3045828 PubMed 3522543 http://www.ncbi.nlm.nih.gov/pubmed/3522543 PubMed 3533724 http://www.ncbi.nlm.nih.gov/pubmed/3533724 PubMed 3537962 http://www.ncbi.nlm.nih.gov/pubmed/3537962 PubMed 3910843 http://www.ncbi.nlm.nih.gov/pubmed/3910843 PubMed 3912261 http://www.ncbi.nlm.nih.gov/pubmed/3912261 PubMed 6273802 http://www.ncbi.nlm.nih.gov/pubmed/6273802 PubMed 7022451 http://www.ncbi.nlm.nih.gov/pubmed/7022451 PubMed 7035431 http://www.ncbi.nlm.nih.gov/pubmed/7035431 PubMed 7577993 http://www.ncbi.nlm.nih.gov/pubmed/7577993 PubMed 8652582 http://www.ncbi.nlm.nih.gov/pubmed/8652582 PubMed 9253408 http://www.ncbi.nlm.nih.gov/pubmed/9253408 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9533886 http://www.ncbi.nlm.nih.gov/pubmed/9533886 RefSeq NP_414917 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414917 RefSeq WP_000814403 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000814403 SMART SM00098 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00098 SMR P00634 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00634 STRING 511145.b0383 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0383&targetmode=cogs STRING COG1785 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1785&targetmode=cogs SUPFAM SSF53649 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53649 UniProtKB PPB_ECOLI http://www.uniprot.org/uniprot/PPB_ECOLI UniProtKB-AC P00634 http://www.uniprot.org/uniprot/P00634 charge swissprot:PPB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PPB_ECOLI eggNOG COG1785 http://eggnogapi.embl.de/nog_data/html/tree/COG1785 eggNOG ENOG4105G6Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105G6Z epestfind swissprot:PPB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PPB_ECOLI garnier swissprot:PPB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PPB_ECOLI helixturnhelix swissprot:PPB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PPB_ECOLI hmoment swissprot:PPB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PPB_ECOLI iep swissprot:PPB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PPB_ECOLI inforesidue swissprot:PPB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PPB_ECOLI octanol swissprot:PPB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PPB_ECOLI pepcoil swissprot:PPB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PPB_ECOLI pepdigest swissprot:PPB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PPB_ECOLI pepinfo swissprot:PPB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PPB_ECOLI pepnet swissprot:PPB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PPB_ECOLI pepstats swissprot:PPB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PPB_ECOLI pepwheel swissprot:PPB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PPB_ECOLI pepwindow swissprot:PPB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PPB_ECOLI sigcleave swissprot:PPB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PPB_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=10.1 uM for SEPHCHC (at 25 degrees Celsius and pH 7) {ECO 0000269|PubMed:18284213}; # BRENDA 3.1.2 2026 # BioGrid 4260505 14 # CATALYTIC ACTIVITY MENH_ECOLI 5-enolpyruvoyl-6-hydroxy-2-succinylcyclohex-3- ene-1-carboxylate = (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4- diene-1-carboxylate + pyruvate. {ECO 0000255|HAMAP-Rule MF_01660, ECO 0000269|PubMed 18284213}. # ESTHER ecoli-YFBB MenH_SHCHC # EcoGene EG12438 menH # FUNCTION MENH_ECOLI Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro. {ECO 0000269|PubMed 15808744, ECO 0000269|PubMed 18284213}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0016787 hydrolase activity; IBA:GO_Central. # GO_function GO:0070205 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity; IDA:EcoCyc. # GO_process GO:0009234 menaquinone biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.1820 -; 1. # HAMAP MF_01660 MenH # IntAct P37355 5 # InterPro IPR000073 AB_hydrolase_1 # InterPro IPR022485 SHCHC_synthase_MenH # InterPro IPR029058 AB_hydrolase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00130 Ubiquinone and other terpenoid-quinone biosynthesis # Organism MENH_ECOLI Escherichia coli (strain K12) # PATHWAY Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 3/7. {ECO 0000255|HAMAP-Rule:MF_01660}. # PATHWAY Quinol/quinone metabolism; menaquinone biosynthesis. {ECO:0000255|HAMAP-Rule MF_01660}. # PATRIC 32119893 VBIEscCol129921_2356 # PDB 4GDM X-ray; 2.75 A; A/B/C=1-252 # PDB 4GEC X-ray; 2.50 A; A/B/C=1-252 # PDB 4GEG X-ray; 2.49 A; A/B/C=1-252 # PDB 4MXD X-ray; 1.45 A; A=1-252 # PDB 4MYD X-ray; 1.37 A; A/B/C=1-252 # PDB 4MYS X-ray; 1.42 A; A/B/C=1-252 # PIR E64997 E64997 # Pfam PF12697 Abhydrolase_6 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase {ECO:0000255|HAMAP-Rule MF_01660} # RefSeq NP_416766 NC_000913.3 # RefSeq WP_000600499 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA24151.1; Type=Frameshift; Positions=182; Evidence={ECO:0000305}; Sequence=M93421; Type=Frameshift; Positions=182; Evidence={ECO 0000305}; # SIMILARITY Belongs to the AB hydrolase superfamily. MenH family. {ECO:0000255|HAMAP-Rule MF_01660, ECO:0000305}. # SUBUNIT MENH_ECOLI Monomer. {ECO 0000255|HAMAP-Rule MF_01660, ECO 0000269|PubMed 18284213}. # SUPFAM SSF53474 SSF53474 # TIGRFAMs TIGR03695 menH_SHCHC # UniPathway UPA01057 UER00900 # eggNOG COG0596 LUCA # eggNOG ENOG4107J5P Bacteria BLAST swissprot:MENH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MENH_ECOLI BioCyc ECOL316407:JW2258-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2258-MONOMER BioCyc EcoCyc:EG12438-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12438-MONOMER BioCyc MetaCyc:EG12438-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12438-MONOMER COG COG0596 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0596 DOI 10.1016/j.fmrre.2004.12.006 http://dx.doi.org/10.1016/j.fmrre.2004.12.006 DOI 10.1021/bi7023755 http://dx.doi.org/10.1021/bi7023755 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.99.20 {ECO:0000255|HAMAP-Rule:MF_01660} http://www.genome.jp/dbget-bin/www_bget?EC:4.2.99.20 {ECO:0000255|HAMAP-Rule:MF_01660} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L35030 http://www.ebi.ac.uk/ena/data/view/L35030 EMBL M93421 http://www.ebi.ac.uk/ena/data/view/M93421 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 4.2.99.20 {ECO:0000255|HAMAP-Rule:MF_01660} http://enzyme.expasy.org/EC/4.2.99.20 {ECO:0000255|HAMAP-Rule:MF_01660} EchoBASE EB2333 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2333 EcoGene EG12438 http://www.ecogene.org/geneInfo.php?eg_id=EG12438 EnsemblBacteria AAC75323 http://www.ensemblgenomes.org/id/AAC75323 EnsemblBacteria AAC75323 http://www.ensemblgenomes.org/id/AAC75323 EnsemblBacteria BAA16087 http://www.ensemblgenomes.org/id/BAA16087 EnsemblBacteria BAA16087 http://www.ensemblgenomes.org/id/BAA16087 EnsemblBacteria BAA16087 http://www.ensemblgenomes.org/id/BAA16087 EnsemblBacteria b2263 http://www.ensemblgenomes.org/id/b2263 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0016787 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016787 GO_function GO:0070205 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070205 GO_process GO:0009234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009234 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.1820 http://www.cathdb.info/version/latest/superfamily/3.40.50.1820 GeneID 946736 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946736 HAMAP MF_01660 http://hamap.expasy.org/unirule/MF_01660 HOGENOM HOG000028072 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000028072&db=HOGENOM6 InParanoid P37355 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37355 IntAct P37355 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37355* IntEnz 4.2.99.20 {ECO:0000255|HAMAP-Rule:MF_01660} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.99.20 {ECO:0000255|HAMAP-Rule:MF_01660} InterPro IPR000073 http://www.ebi.ac.uk/interpro/entry/IPR000073 InterPro IPR022485 http://www.ebi.ac.uk/interpro/entry/IPR022485 InterPro IPR029058 http://www.ebi.ac.uk/interpro/entry/IPR029058 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2258 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2258 KEGG_Gene eco:b2263 http://www.genome.jp/dbget-bin/www_bget?eco:b2263 KEGG_Orthology KO:K08680 http://www.genome.jp/dbget-bin/www_bget?KO:K08680 KEGG_Pathway ko00130 http://www.genome.jp/kegg-bin/show_pathway?ko00130 KEGG_Reaction rn:R08166 http://www.genome.jp/dbget-bin/www_bget?rn:R08166 OMA LNDWYQQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LNDWYQQ PDB 4GDM http://www.ebi.ac.uk/pdbe-srv/view/entry/4GDM PDB 4GEC http://www.ebi.ac.uk/pdbe-srv/view/entry/4GEC PDB 4GEG http://www.ebi.ac.uk/pdbe-srv/view/entry/4GEG PDB 4MXD http://www.ebi.ac.uk/pdbe-srv/view/entry/4MXD PDB 4MYD http://www.ebi.ac.uk/pdbe-srv/view/entry/4MYD PDB 4MYS http://www.ebi.ac.uk/pdbe-srv/view/entry/4MYS PDBsum 4GDM http://www.ebi.ac.uk/pdbsum/4GDM PDBsum 4GEC http://www.ebi.ac.uk/pdbsum/4GEC PDBsum 4GEG http://www.ebi.ac.uk/pdbsum/4GEG PDBsum 4MXD http://www.ebi.ac.uk/pdbsum/4MXD PDBsum 4MYD http://www.ebi.ac.uk/pdbsum/4MYD PDBsum 4MYS http://www.ebi.ac.uk/pdbsum/4MYS PSORT swissprot:MENH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MENH_ECOLI PSORT-B swissprot:MENH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MENH_ECOLI PSORT2 swissprot:MENH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MENH_ECOLI Pfam PF12697 http://pfam.xfam.org/family/PF12697 Phobius swissprot:MENH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MENH_ECOLI PhylomeDB P37355 http://phylomedb.org/?seqid=P37355 ProteinModelPortal P37355 http://www.proteinmodelportal.org/query/uniprot/P37355 PubMed 15808744 http://www.ncbi.nlm.nih.gov/pubmed/15808744 PubMed 1629162 http://www.ncbi.nlm.nih.gov/pubmed/1629162 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18284213 http://www.ncbi.nlm.nih.gov/pubmed/18284213 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416766 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416766 RefSeq WP_000600499 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000600499 SMR P37355 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37355 STRING 511145.b2263 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2263&targetmode=cogs STRING COG0596 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0596&targetmode=cogs SUPFAM SSF53474 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53474 TIGRFAMs TIGR03695 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03695 UniProtKB MENH_ECOLI http://www.uniprot.org/uniprot/MENH_ECOLI UniProtKB-AC P37355 http://www.uniprot.org/uniprot/P37355 charge swissprot:MENH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MENH_ECOLI eggNOG COG0596 http://eggnogapi.embl.de/nog_data/html/tree/COG0596 eggNOG ENOG4107J5P http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107J5P epestfind swissprot:MENH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MENH_ECOLI garnier swissprot:MENH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MENH_ECOLI helixturnhelix swissprot:MENH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MENH_ECOLI hmoment swissprot:MENH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MENH_ECOLI iep swissprot:MENH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MENH_ECOLI inforesidue swissprot:MENH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MENH_ECOLI octanol swissprot:MENH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MENH_ECOLI pepcoil swissprot:MENH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MENH_ECOLI pepdigest swissprot:MENH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MENH_ECOLI pepinfo swissprot:MENH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MENH_ECOLI pepnet swissprot:MENH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MENH_ECOLI pepstats swissprot:MENH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MENH_ECOLI pepwheel swissprot:MENH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MENH_ECOLI pepwindow swissprot:MENH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MENH_ECOLI sigcleave swissprot:MENH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MENH_ECOLI ## Database ID URL or Descriptions # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG14339 yifN # GO_function GO:0003677 DNA binding; IEA:InterPro. # GOslim_function GO:0003677 DNA binding # IntAct P56259 4 # InterPro IPR003477 PemK-like # Organism YIFN_ECOLI Escherichia coli (strain K12) # PIR C65181 C65181 # PIR D65181 D65181 # Pfam PF02452 PemK_toxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIFN_ECOLI Putative uncharacterized protein YifN # SEQUENCE CAUTION Sequence=BAE77521.1; Type=Frameshift; Positions=71; Evidence={ECO:0000305}; Sequence=M87049; Type=Frameshift; Positions=71; Evidence={ECO 0000305}; Sequence=U00096; Type=Frameshift; Positions=71; Note=Produces two separate ORFs.; Evidence={ECO:0000305}; # eggNOG COG3692 LUCA BLAST swissprot:YIFN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIFN_ECOLI BioCyc ECOL316407:JW3749-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3749-MONOMER BioCyc EcoCyc:G7797-MONOMER http://biocyc.org/getid?id=EcoCyc:G7797-MONOMER BioCyc EcoCyc:G7798-MONOMER http://biocyc.org/getid?id=EcoCyc:G7798-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4085 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4085 EcoGene EG14339 http://www.ecogene.org/geneInfo.php?eg_id=EG14339 EnsemblBacteria BAE77521 http://www.ensemblgenomes.org/id/BAE77521 EnsemblBacteria BAE77521 http://www.ensemblgenomes.org/id/BAE77521 EnsemblBacteria BAE77521 http://www.ensemblgenomes.org/id/BAE77521 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 HOGENOM HOG000009645 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009645&db=HOGENOM6 IntAct P56259 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P56259* InterPro IPR003477 http://www.ebi.ac.uk/interpro/entry/IPR003477 KEGG_Gene ecj:JW3749 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3749 OMA WIKSELI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WIKSELI PSORT swissprot:YIFN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIFN_ECOLI PSORT-B swissprot:YIFN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIFN_ECOLI PSORT2 swissprot:YIFN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIFN_ECOLI Pfam PF02452 http://pfam.xfam.org/family/PF02452 Phobius swissprot:YIFN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIFN_ECOLI ProteinModelPortal P56259 http://www.proteinmodelportal.org/query/uniprot/P56259 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 STRING 316407.85676271 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85676271&targetmode=cogs UniProtKB YIFN_ECOLI http://www.uniprot.org/uniprot/YIFN_ECOLI UniProtKB-AC P56259 http://www.uniprot.org/uniprot/P56259 charge swissprot:YIFN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIFN_ECOLI eggNOG COG3692 http://eggnogapi.embl.de/nog_data/html/tree/COG3692 epestfind swissprot:YIFN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIFN_ECOLI garnier swissprot:YIFN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIFN_ECOLI helixturnhelix swissprot:YIFN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIFN_ECOLI hmoment swissprot:YIFN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIFN_ECOLI iep swissprot:YIFN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIFN_ECOLI inforesidue swissprot:YIFN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIFN_ECOLI octanol swissprot:YIFN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIFN_ECOLI pepcoil swissprot:YIFN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIFN_ECOLI pepdigest swissprot:YIFN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIFN_ECOLI pepinfo swissprot:YIFN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIFN_ECOLI pepnet swissprot:YIFN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIFN_ECOLI pepstats swissprot:YIFN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIFN_ECOLI pepwheel swissprot:YIFN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIFN_ECOLI pepwindow swissprot:YIFN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIFN_ECOLI sigcleave swissprot:YIFN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIFN_ECOLI ## Database ID URL or Descriptions # AltName AMPP_ECOLI Aminoacylproline aminopeptidase # AltName AMPP_ECOLI Aminopeptidase P II # AltName AMPP_ECOLI X-Pro aminopeptidase # BRENDA 3.1.8 2026 # BRENDA 3.4.11 2026 # BioGrid 4259236 11 # CATALYTIC ACTIVITY AMPP_ECOLI Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide. # COFACTOR Name=Mn(2+); Xref=ChEBI:CHEBI 29035; Note=Binds 2 manganese ions per subunit.; # EcoGene EG10697 pepP # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0004177 aminopeptidase activity; IDA:EcoCyc. # GO_function GO:0008235 metalloexopeptidase activity; IDA:EcoCyc. # GO_function GO:0030145 manganese ion binding; IMP:EcoCyc. # GO_function GO:0042802 identical protein binding; IPI:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.350.10 -; 1. # Gene3D 3.90.230.10 -; 1. # INTERACTION AMPP_ECOLI P60560 guaC; NbExp=2; IntAct=EBI-554801, EBI-544491; # IntAct P15034 10 # InterPro IPR000994 Pept_M24 # InterPro IPR001131 Peptidase_M24B_aminopep-P_CS # InterPro IPR001714 Pept_M24_MAP # InterPro IPR007865 Aminopep_P_N # InterPro IPR028980 Creatinase/Aminopeptidase_P_N # InterPro IPR029149 Creatin/AminoP/Spt16_NTD # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # Organism AMPP_ECOLI Escherichia coli (strain K12) # PATRIC 32121230 VBIEscCol129921_3003 # PDB 1A16 X-ray; 2.30 A; A=2-441 # PDB 1JAW X-ray; 2.70 A; A=2-441 # PDB 1M35 X-ray; 2.40 A; A/B/C/D/E/F=2-441 # PDB 1N51 X-ray; 2.30 A; A=2-441 # PDB 1W2M X-ray; 2.40 A; A/B/C/D/E/F=2-441 # PDB 1W7V X-ray; 2.00 A; A/B/C/D=2-441 # PDB 1WBQ X-ray; 2.30 A; A/B/C/D=2-441 # PDB 1WL6 X-ray; 2.00 A; A=2-441 # PDB 1WL9 X-ray; 1.90 A; A=2-441 # PDB 1WLR X-ray; 2.10 A; A=2-441 # PDB 2BH3 X-ray; 2.40 A; A=2-441 # PDB 2BHA X-ray; 2.40 A; A=2-441 # PDB 2BHB X-ray; 2.41 A; A=2-441 # PDB 2BHC X-ray; 2.40 A; A=2-441 # PDB 2BHD X-ray; 2.50 A; A=2-441 # PDB 2BN7 X-ray; 2.40 A; A=2-441 # PDB 2BWS X-ray; 1.75 A; A=2-441 # PDB 2BWT X-ray; 2.90 A; A=2-441 # PDB 2BWU X-ray; 2.20 A; A=2-441 # PDB 2BWV X-ray; 1.70 A; A=2-441 # PDB 2BWW X-ray; 2.61 A; A=2-441 # PDB 2BWX X-ray; 1.70 A; A=2-441 # PDB 2BWY X-ray; 2.40 A; A=2-441 # PDB 2V3X X-ray; 1.70 A; A=2-441 # PDB 2V3Y X-ray; 1.60 A; A=2-441 # PDB 2V3Z X-ray; 1.56 A; A=2-441 # PIR JX0067 DPECP # PRINTS PR00599 MAPEPTIDASE # PROSITE PS00491 PROLINE_PEPTIDASE # Pfam PF00557 Peptidase_M24 # Pfam PF05195 AMP_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AMPP_ECOLI Xaa-Pro aminopeptidase # RefSeq NP_417384 NC_000913.3 # RefSeq WP_001290136 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase M24B family. {ECO 0000305}. # SMART SM01011 AMP_N # SUBCELLULAR LOCATION AMPP_ECOLI Cytoplasm. # SUBUNIT AMPP_ECOLI Homotetramer. # SUPFAM SSF53092 SSF53092 # SUPFAM SSF55920 SSF55920 # eggNOG COG0006 LUCA # eggNOG ENOG4107RAQ Bacteria BLAST swissprot:AMPP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AMPP_ECOLI BioCyc ECOL316407:JW2876-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2876-MONOMER BioCyc EcoCyc:EG10697-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10697-MONOMER BioCyc MetaCyc:EG10697-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10697-MONOMER COG COG0006 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0006 DIP DIP-10459N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10459N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.95.7.3472 http://dx.doi.org/10.1073/pnas.95.7.3472 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.11.9 http://www.genome.jp/dbget-bin/www_bget?EC:3.4.11.9 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D00398 http://www.ebi.ac.uk/ena/data/view/D00398 EMBL D90281 http://www.ebi.ac.uk/ena/data/view/D90281 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 ENZYME 3.4.11.9 http://enzyme.expasy.org/EC/3.4.11.9 EchoBASE EB0691 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0691 EcoGene EG10697 http://www.ecogene.org/geneInfo.php?eg_id=EG10697 EnsemblBacteria AAC75946 http://www.ensemblgenomes.org/id/AAC75946 EnsemblBacteria AAC75946 http://www.ensemblgenomes.org/id/AAC75946 EnsemblBacteria BAE76973 http://www.ensemblgenomes.org/id/BAE76973 EnsemblBacteria BAE76973 http://www.ensemblgenomes.org/id/BAE76973 EnsemblBacteria BAE76973 http://www.ensemblgenomes.org/id/BAE76973 EnsemblBacteria b2908 http://www.ensemblgenomes.org/id/b2908 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004177 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004177 GO_function GO:0008235 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008235 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.350.10 http://www.cathdb.info/version/latest/superfamily/3.40.350.10 Gene3D 3.90.230.10 http://www.cathdb.info/version/latest/superfamily/3.90.230.10 GeneID 947385 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947385 HOGENOM HOG000008762 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000008762&db=HOGENOM6 InParanoid P15034 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P15034 IntAct P15034 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P15034* IntEnz 3.4.11.9 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.11.9 InterPro IPR000994 http://www.ebi.ac.uk/interpro/entry/IPR000994 InterPro IPR001131 http://www.ebi.ac.uk/interpro/entry/IPR001131 InterPro IPR001714 http://www.ebi.ac.uk/interpro/entry/IPR001714 InterPro IPR007865 http://www.ebi.ac.uk/interpro/entry/IPR007865 InterPro IPR028980 http://www.ebi.ac.uk/interpro/entry/IPR028980 InterPro IPR029149 http://www.ebi.ac.uk/interpro/entry/IPR029149 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW2876 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2876 KEGG_Gene eco:b2908 http://www.genome.jp/dbget-bin/www_bget?eco:b2908 KEGG_Orthology KO:K01262 http://www.genome.jp/dbget-bin/www_bget?KO:K01262 MINT MINT-1252312 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1252312 OMA KDPLMET http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KDPLMET PDB 1A16 http://www.ebi.ac.uk/pdbe-srv/view/entry/1A16 PDB 1JAW http://www.ebi.ac.uk/pdbe-srv/view/entry/1JAW PDB 1M35 http://www.ebi.ac.uk/pdbe-srv/view/entry/1M35 PDB 1N51 http://www.ebi.ac.uk/pdbe-srv/view/entry/1N51 PDB 1W2M http://www.ebi.ac.uk/pdbe-srv/view/entry/1W2M PDB 1W7V http://www.ebi.ac.uk/pdbe-srv/view/entry/1W7V PDB 1WBQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1WBQ PDB 1WL6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1WL6 PDB 1WL9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1WL9 PDB 1WLR http://www.ebi.ac.uk/pdbe-srv/view/entry/1WLR PDB 2BH3 http://www.ebi.ac.uk/pdbe-srv/view/entry/2BH3 PDB 2BHA http://www.ebi.ac.uk/pdbe-srv/view/entry/2BHA PDB 2BHB http://www.ebi.ac.uk/pdbe-srv/view/entry/2BHB PDB 2BHC http://www.ebi.ac.uk/pdbe-srv/view/entry/2BHC PDB 2BHD http://www.ebi.ac.uk/pdbe-srv/view/entry/2BHD PDB 2BN7 http://www.ebi.ac.uk/pdbe-srv/view/entry/2BN7 PDB 2BWS http://www.ebi.ac.uk/pdbe-srv/view/entry/2BWS PDB 2BWT http://www.ebi.ac.uk/pdbe-srv/view/entry/2BWT PDB 2BWU http://www.ebi.ac.uk/pdbe-srv/view/entry/2BWU PDB 2BWV http://www.ebi.ac.uk/pdbe-srv/view/entry/2BWV PDB 2BWW http://www.ebi.ac.uk/pdbe-srv/view/entry/2BWW PDB 2BWX http://www.ebi.ac.uk/pdbe-srv/view/entry/2BWX PDB 2BWY http://www.ebi.ac.uk/pdbe-srv/view/entry/2BWY PDB 2V3X http://www.ebi.ac.uk/pdbe-srv/view/entry/2V3X PDB 2V3Y http://www.ebi.ac.uk/pdbe-srv/view/entry/2V3Y PDB 2V3Z http://www.ebi.ac.uk/pdbe-srv/view/entry/2V3Z PDBsum 1A16 http://www.ebi.ac.uk/pdbsum/1A16 PDBsum 1JAW http://www.ebi.ac.uk/pdbsum/1JAW PDBsum 1M35 http://www.ebi.ac.uk/pdbsum/1M35 PDBsum 1N51 http://www.ebi.ac.uk/pdbsum/1N51 PDBsum 1W2M http://www.ebi.ac.uk/pdbsum/1W2M PDBsum 1W7V http://www.ebi.ac.uk/pdbsum/1W7V PDBsum 1WBQ http://www.ebi.ac.uk/pdbsum/1WBQ PDBsum 1WL6 http://www.ebi.ac.uk/pdbsum/1WL6 PDBsum 1WL9 http://www.ebi.ac.uk/pdbsum/1WL9 PDBsum 1WLR http://www.ebi.ac.uk/pdbsum/1WLR PDBsum 2BH3 http://www.ebi.ac.uk/pdbsum/2BH3 PDBsum 2BHA http://www.ebi.ac.uk/pdbsum/2BHA PDBsum 2BHB http://www.ebi.ac.uk/pdbsum/2BHB PDBsum 2BHC http://www.ebi.ac.uk/pdbsum/2BHC PDBsum 2BHD http://www.ebi.ac.uk/pdbsum/2BHD PDBsum 2BN7 http://www.ebi.ac.uk/pdbsum/2BN7 PDBsum 2BWS http://www.ebi.ac.uk/pdbsum/2BWS PDBsum 2BWT http://www.ebi.ac.uk/pdbsum/2BWT PDBsum 2BWU http://www.ebi.ac.uk/pdbsum/2BWU PDBsum 2BWV http://www.ebi.ac.uk/pdbsum/2BWV PDBsum 2BWW http://www.ebi.ac.uk/pdbsum/2BWW PDBsum 2BWX http://www.ebi.ac.uk/pdbsum/2BWX PDBsum 2BWY http://www.ebi.ac.uk/pdbsum/2BWY PDBsum 2V3X http://www.ebi.ac.uk/pdbsum/2V3X PDBsum 2V3Y http://www.ebi.ac.uk/pdbsum/2V3Y PDBsum 2V3Z http://www.ebi.ac.uk/pdbsum/2V3Z PRINTS PR00599 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00599 PROSITE PS00491 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00491 PSORT swissprot:AMPP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AMPP_ECOLI PSORT-B swissprot:AMPP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AMPP_ECOLI PSORT2 swissprot:AMPP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AMPP_ECOLI Pfam PF00557 http://pfam.xfam.org/family/PF00557 Pfam PF05195 http://pfam.xfam.org/family/PF05195 Phobius swissprot:AMPP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AMPP_ECOLI PhylomeDB P15034 http://phylomedb.org/?seqid=P15034 ProteinModelPortal P15034 http://www.proteinmodelportal.org/query/uniprot/P15034 PubMed 1339425 http://www.ncbi.nlm.nih.gov/pubmed/1339425 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2659585 http://www.ncbi.nlm.nih.gov/pubmed/2659585 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9520390 http://www.ncbi.nlm.nih.gov/pubmed/9520390 RefSeq NP_417384 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417384 RefSeq WP_001290136 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001290136 SMART SM01011 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01011 SMR P15034 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P15034 STRING 511145.b2908 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2908&targetmode=cogs STRING COG0006 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0006&targetmode=cogs SUPFAM SSF53092 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53092 SUPFAM SSF55920 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55920 UniProtKB AMPP_ECOLI http://www.uniprot.org/uniprot/AMPP_ECOLI UniProtKB-AC P15034 http://www.uniprot.org/uniprot/P15034 charge swissprot:AMPP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AMPP_ECOLI eggNOG COG0006 http://eggnogapi.embl.de/nog_data/html/tree/COG0006 eggNOG ENOG4107RAQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107RAQ epestfind swissprot:AMPP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AMPP_ECOLI garnier swissprot:AMPP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AMPP_ECOLI helixturnhelix swissprot:AMPP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AMPP_ECOLI hmoment swissprot:AMPP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AMPP_ECOLI iep swissprot:AMPP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AMPP_ECOLI inforesidue swissprot:AMPP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AMPP_ECOLI octanol swissprot:AMPP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AMPP_ECOLI pepcoil swissprot:AMPP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AMPP_ECOLI pepdigest swissprot:AMPP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AMPP_ECOLI pepinfo swissprot:AMPP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AMPP_ECOLI pepnet swissprot:AMPP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AMPP_ECOLI pepstats swissprot:AMPP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AMPP_ECOLI pepwheel swissprot:AMPP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AMPP_ECOLI pepwindow swissprot:AMPP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AMPP_ECOLI sigcleave swissprot:AMPP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AMPP_ECOLI ## Database ID URL or Descriptions # AltName GMHBB_ECOLI D,D-heptose 1,7-bisphosphate phosphatase # BIOPHYSICOCHEMICAL PROPERTIES GMHBB_ECOLI Kinetic parameters KM=5 uM for beta-HBP (at pH 7.5 and 25 degrees Celsius) {ECO 0000269|PubMed 16990279, ECO 0000269|PubMed 20050615, ECO 0000269|PubMed 20050699}; KM=67 uM for alpha-HBP (at pH 7.5 and 25 degrees Celsius) {ECO 0000269|PubMed 16990279, ECO 0000269|PubMed 20050615, ECO 0000269|PubMed 20050699}; KM=0.20 mM for HBP (at pH 8) {ECO 0000269|PubMed 16990279, ECO 0000269|PubMed 20050615, ECO 0000269|PubMed 20050699}; KM=0.42 mM for fructose-1,6-bisphosphate (at pH 9) {ECO 0000269|PubMed 16990279, ECO 0000269|PubMed 20050615, ECO 0000269|PubMed 20050699}; KM=610 uM for sedoheptulose-1,7-bisphosphate (at pH 7.5) {ECO 0000269|PubMed 16990279, ECO 0000269|PubMed 20050615, ECO 0000269|PubMed 20050699}; KM=1501 uM for fructose-1,6-bisphosphate (at pH 7.5) {ECO 0000269|PubMed 16990279, ECO 0000269|PubMed 20050615, ECO 0000269|PubMed 20050699}; Note=kcat is 35.7 sec(-1) and 4.6 sec(-1) with beta-HBP and alpha-HBP as substrate, respectively. Thus, the enzyme displays 100-fold more efficiency towards the beta- than the alpha-anomer (PubMed 20050615). kcat is 0.51 sec(-1) and 0.039 sec(-1) with sedoheptulose-1,7-bisphosphate and fructose-1,6-bisphosphate as substrate, respectively (PubMed 20050615). {ECO 0000269|PubMed 20050615}; pH dependence Optimum pH is between 6 and 7.5. {ECO 0000269|PubMed 16990279, ECO 0000269|PubMed 20050699}; # BRENDA 3.1.3.82 2026 # BioGrid 4259752 280 # CATALYTIC ACTIVITY GMHBB_ECOLI D-glycero-beta-D-manno-heptose 1,7- bisphosphate + H(2)O = D-glycero-beta-D-manno-heptose 1-phosphate + phosphate. {ECO 0000269|PubMed 11751812, ECO 0000269|PubMed 16990279, ECO 0000269|PubMed 20050614, ECO 0000269|PubMed 20050615}. # COFACTOR GMHBB_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 16990279, ECO 0000269|PubMed 20050614}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 16990279, ECO 0000269|PubMed 20050614}; Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000269|PubMed 16990279}; Note=Magnesium. Can also use other divalent metal cations as manganese and cobalt. {ECO 0000269|PubMed 16990279}; # COFACTOR GMHBB_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 16990279}; # DISRUPTION PHENOTYPE GMHBB_ECOLI Cells lacking this gene result in the formation of an altered LPS core, but does not appear to disrupt full-length LPS production to an extent that the outer membrane permeability barrier is compromised. {ECO 0000269|PubMed 11751812, ECO 0000269|PubMed 20050699}. # EcoGene EG11736 gmhB # FUNCTION GMHBB_ECOLI Converts the D-glycero-beta-D-manno-heptose 1,7- bisphosphate (beta-HBP) intermediate into D-glycero-beta-D-manno- heptose 1-phosphate by removing the phosphate group at the C-7 position. {ECO 0000269|PubMed 11751812, ECO 0000269|PubMed 16990279, ECO 0000269|PubMed 20050615}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IDA:UniProtKB. # GO_function GO:0008270 zinc ion binding; IDA:UniProtKB. # GO_function GO:0034200 D,D-heptose 1,7-bisphosphate phosphatase activity; IDA:UniProtKB. # GO_process GO:0009244 lipopolysaccharide core region biosynthetic process; IMP:EcoCyc. # GO_process GO:0097171 ADP-L-glycero-beta-D-manno-heptose biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.50.1000 -; 1. # IntAct P63228 11 # InterPro IPR004446 Heptose_bisP_phosphatase # InterPro IPR006543 Histidinol-phos # InterPro IPR006549 HAD-SF_hydro_IIIA # InterPro IPR023214 HAD-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # KEGG_Pathway ko00540 Lipopolysaccharide biosynthesis # MISCELLANEOUS GMHBB_ECOLI Phosphatase activity is essential for nucleotide activation (fourth step). Zinc ion does not directly participate in catalysis, but probably functions to stabilize the loop conformation. # Organism GMHBB_ECOLI Escherichia coli (strain K12) # PATHWAY GMHBB_ECOLI Bacterial outer membrane biogenesis; LPS core biosynthesis. {ECO 0000269|PubMed 11751812, ECO 0000269|PubMed 20050699}. # PATHWAY GMHBB_ECOLI Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D- manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate step 2/4. {ECO 0000269|PubMed 11751812, ECO 0000269|PubMed 16990279, ECO 0000269|PubMed 20050615}. # PATRIC 32115513 VBIEscCol129921_0208 # PDB 2GMW X-ray; 1.50 A; A/B=1-191 # PDB 3ESQ X-ray; 1.70 A; A=1-191 # PDB 3ESR X-ray; 1.95 A; A=1-191 # PDB 3L1U X-ray; 1.95 A; A/B=1-191 # PDB 3L1V X-ray; 1.95 A; A/B=1-191 # PDB 3L8E X-ray; 1.64 A; A/B=1-187 # PDB 3L8F X-ray; 1.79 A; A=1-187 # PDB 3L8G X-ray; 2.18 A; A=1-187 # PIR H64744 H64744 # PIRSF PIRSF004682 GmhB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GMHBB_ECOLI D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase # RefSeq NP_414742 NC_000913.3 # RefSeq WP_001140187 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA03661.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the GmhB family. {ECO 0000305}. # SUBCELLULAR LOCATION GMHBB_ECOLI Cytoplasm {ECO 0000250}. # SUBUNIT GMHBB_ECOLI Monomer. {ECO 0000269|PubMed 20050614, ECO 0000269|PubMed 20050699}. # SUPFAM SSF56784 SSF56784 # TIGRFAMs TIGR00213 GmhB_yaeD # TIGRFAMs TIGR01656 Histidinol-ppas # TIGRFAMs TIGR01662 HAD-SF-IIIA # UniPathway UPA00356 UER00438 # eggNOG COG0241 LUCA # eggNOG ENOG4108ZI0 Bacteria BLAST swissprot:GMHBB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GMHBB_ECOLI BioCyc ECOL316407:JW0196-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0196-MONOMER BioCyc EcoCyc:EG11736-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11736-MONOMER BioCyc MetaCyc:EG11736-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11736-MONOMER COG COG0241 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0241 DIP DIP-47998N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47998N DOI 10.1021/bi901780j http://dx.doi.org/10.1021/bi901780j DOI 10.1021/bi902018y http://dx.doi.org/10.1021/bi902018y DOI 10.1021/bi902019q http://dx.doi.org/10.1021/bi902019q DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M605449200 http://dx.doi.org/10.1074/jbc.M605449200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.2.363-369.2002 http://dx.doi.org/10.1128/JB.184.2.363-369.2002 EC_number EC:3.1.3.82 {ECO:0000269|PubMed:11751812, ECO:0000269|PubMed:16990279, ECO:0000269|PubMed:20050614, ECO:0000269|PubMed:20050615} http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.82 {ECO:0000269|PubMed:11751812, ECO:0000269|PubMed:16990279, ECO:0000269|PubMed:20050614, ECO:0000269|PubMed:20050615} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D15061 http://www.ebi.ac.uk/ena/data/view/D15061 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 ENZYME 3.1.3.82 {ECO:0000269|PubMed:11751812, ECO:0000269|PubMed:16990279, ECO:0000269|PubMed:20050614, ECO:0000269|PubMed:20050615} http://enzyme.expasy.org/EC/3.1.3.82 {ECO:0000269|PubMed:11751812, ECO:0000269|PubMed:16990279, ECO:0000269|PubMed:20050614, ECO:0000269|PubMed:20050615} EchoBASE EB1687 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1687 EcoGene EG11736 http://www.ecogene.org/geneInfo.php?eg_id=EG11736 EnsemblBacteria AAC73311 http://www.ensemblgenomes.org/id/AAC73311 EnsemblBacteria AAC73311 http://www.ensemblgenomes.org/id/AAC73311 EnsemblBacteria BAA77877 http://www.ensemblgenomes.org/id/BAA77877 EnsemblBacteria BAA77877 http://www.ensemblgenomes.org/id/BAA77877 EnsemblBacteria BAA77877 http://www.ensemblgenomes.org/id/BAA77877 EnsemblBacteria b0200 http://www.ensemblgenomes.org/id/b0200 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0034200 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034200 GO_process GO:0009244 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009244 GO_process GO:0097171 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097171 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.50.1000 http://www.cathdb.info/version/latest/superfamily/3.40.50.1000 GeneID 944879 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944879 HOGENOM HOG000016501 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000016501&db=HOGENOM6 InParanoid P63228 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P63228 IntAct P63228 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P63228* IntEnz 3.1.3.82 {ECO:0000269|PubMed:11751812, ECO:0000269|PubMed:16990279, ECO:0000269|PubMed:20050614, ECO:0000269|PubMed:20050615} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.82 {ECO:0000269|PubMed:11751812, ECO:0000269|PubMed:16990279, ECO:0000269|PubMed:20050614, ECO:0000269|PubMed:20050615} InterPro IPR004446 http://www.ebi.ac.uk/interpro/entry/IPR004446 InterPro IPR006543 http://www.ebi.ac.uk/interpro/entry/IPR006543 InterPro IPR006549 http://www.ebi.ac.uk/interpro/entry/IPR006549 InterPro IPR023214 http://www.ebi.ac.uk/interpro/entry/IPR023214 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Gene ecj:JW0196 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0196 KEGG_Gene eco:b0200 http://www.genome.jp/dbget-bin/www_bget?eco:b0200 KEGG_Orthology KO:K03273 http://www.genome.jp/dbget-bin/www_bget?KO:K03273 KEGG_Pathway ko00540 http://www.genome.jp/kegg-bin/show_pathway?ko00540 KEGG_Reaction rn:R05647 http://www.genome.jp/dbget-bin/www_bget?rn:R05647 KEGG_Reaction rn:R09771 http://www.genome.jp/dbget-bin/www_bget?rn:R09771 OMA SFMIGDK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SFMIGDK PDB 2GMW http://www.ebi.ac.uk/pdbe-srv/view/entry/2GMW PDB 3ESQ http://www.ebi.ac.uk/pdbe-srv/view/entry/3ESQ PDB 3ESR http://www.ebi.ac.uk/pdbe-srv/view/entry/3ESR PDB 3L1U http://www.ebi.ac.uk/pdbe-srv/view/entry/3L1U PDB 3L1V http://www.ebi.ac.uk/pdbe-srv/view/entry/3L1V PDB 3L8E http://www.ebi.ac.uk/pdbe-srv/view/entry/3L8E PDB 3L8F http://www.ebi.ac.uk/pdbe-srv/view/entry/3L8F PDB 3L8G http://www.ebi.ac.uk/pdbe-srv/view/entry/3L8G PDBsum 2GMW http://www.ebi.ac.uk/pdbsum/2GMW PDBsum 3ESQ http://www.ebi.ac.uk/pdbsum/3ESQ PDBsum 3ESR http://www.ebi.ac.uk/pdbsum/3ESR PDBsum 3L1U http://www.ebi.ac.uk/pdbsum/3L1U PDBsum 3L1V http://www.ebi.ac.uk/pdbsum/3L1V PDBsum 3L8E http://www.ebi.ac.uk/pdbsum/3L8E PDBsum 3L8F http://www.ebi.ac.uk/pdbsum/3L8F PDBsum 3L8G http://www.ebi.ac.uk/pdbsum/3L8G PSORT swissprot:GMHBB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GMHBB_ECOLI PSORT-B swissprot:GMHBB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GMHBB_ECOLI PSORT2 swissprot:GMHBB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GMHBB_ECOLI Phobius swissprot:GMHBB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GMHBB_ECOLI PhylomeDB P63228 http://phylomedb.org/?seqid=P63228 ProteinModelPortal P63228 http://www.proteinmodelportal.org/query/uniprot/P63228 PubMed 11751812 http://www.ncbi.nlm.nih.gov/pubmed/11751812 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16990279 http://www.ncbi.nlm.nih.gov/pubmed/16990279 PubMed 20050614 http://www.ncbi.nlm.nih.gov/pubmed/20050614 PubMed 20050615 http://www.ncbi.nlm.nih.gov/pubmed/20050615 PubMed 20050699 http://www.ncbi.nlm.nih.gov/pubmed/20050699 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414742 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414742 RefSeq WP_001140187 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001140187 SMR P63228 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P63228 STRING 511145.b0200 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0200&targetmode=cogs STRING COG0241 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0241&targetmode=cogs SUPFAM SSF56784 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784 TIGRFAMs TIGR00213 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00213 TIGRFAMs TIGR01656 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01656 TIGRFAMs TIGR01662 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01662 UniProtKB GMHBB_ECOLI http://www.uniprot.org/uniprot/GMHBB_ECOLI UniProtKB-AC P63228 http://www.uniprot.org/uniprot/P63228 charge swissprot:GMHBB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GMHBB_ECOLI eggNOG COG0241 http://eggnogapi.embl.de/nog_data/html/tree/COG0241 eggNOG ENOG4108ZI0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZI0 epestfind swissprot:GMHBB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GMHBB_ECOLI garnier swissprot:GMHBB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GMHBB_ECOLI helixturnhelix swissprot:GMHBB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GMHBB_ECOLI hmoment swissprot:GMHBB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GMHBB_ECOLI iep swissprot:GMHBB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GMHBB_ECOLI inforesidue swissprot:GMHBB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GMHBB_ECOLI octanol swissprot:GMHBB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GMHBB_ECOLI pepcoil swissprot:GMHBB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GMHBB_ECOLI pepdigest swissprot:GMHBB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GMHBB_ECOLI pepinfo swissprot:GMHBB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GMHBB_ECOLI pepnet swissprot:GMHBB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GMHBB_ECOLI pepstats swissprot:GMHBB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GMHBB_ECOLI pepwheel swissprot:GMHBB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GMHBB_ECOLI pepwindow swissprot:GMHBB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GMHBB_ECOLI sigcleave swissprot:GMHBB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GMHBB_ECOLI ## Database ID URL or Descriptions # AltName TISB_ECOLI LexA-regulated protein TisB # CAUTION Originally tisA and tisB were fused into one ORF by frameshift reconstruction. TisA is probably a pseudogene. {ECO 0000305}. # DISRUPTION PHENOTYPE Competition experiments between isogenic strains with or without the tisB/istR-1 region were performed. In the presence of DNA-damaging agents deletion strains were disadvantaged and were almost extinct by 4 days. {ECO:0000269|PubMed 18761622}. # EcoGene EG14402 tisB # FUNCTION TISB_ECOLI A toxic protein; overexpression causes cessation of growth. Overexpression induces stress-response, a number of membrane protein genes, and leads to cell death. Part of the programmed response to DNA damage; damage leads to increased accumulation of the protein which slows or stops bacterial growth, probably allowing DNA repair before cells continue to grow. {ECO 0000269|PubMed 15620655, ECO 0000269|PubMed 18710431, ECO 0000269|PubMed 18761622}. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_function GO:0005253 anion channel activity; IDA:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0009432 SOS response; IEP:EcoCyc. # GO_process GO:0022611 dormancy process; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # INDUCTION TISB_ECOLI Part of the SOS-response regulon, controlled by LexA. The sRNA istR-1 inhibits toxicity by sequestering the standby ribosome binding site for tisB; as the levels of istR-1 decrease this site opens and ribosomes are able to bind to initiate translation further downstream. A type I toxin antitoxin (TA) system, where expression of the proteinaceous toxin is controlled by an antisense sRNA. {ECO 0000269|PubMed 15620655, ECO 0000269|PubMed 17499044}. # InterPro IPR025211 TisB_toxin # Organism TISB_ECOLI Escherichia coli (strain K12) # Pfam PF13939 TisB_toxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TISB_ECOLI Small toxic protein TisB # RefSeq WP_001054909 NZ_LN832404.1 # RefSeq YP_001165331 NC_000913.3 # SUBCELLULAR LOCATION TISB_ECOLI Cell inner membrane {ECO 0000269|PubMed 18761622}; Single-pass membrane protein {ECO 0000269|PubMed 18761622}. # TCDB 1.C.103.1 the pore-forming toxin, tisb (tisb) family # TIGRFAMs TIGR04459 TisB_tox BLAST swissprot:TISB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TISB_ECOLI BioCyc EcoCyc:MONOMER0-1922 http://biocyc.org/getid?id=EcoCyc:MONOMER0-1922 DOI 10.1016/j.cub.2004.12.003 http://dx.doi.org/10.1016/j.cub.2004.12.003 DOI 10.1016/j.molcel.2007.04.003 http://dx.doi.org/10.1016/j.molcel.2007.04.003 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2008.06394.x http://dx.doi.org/10.1111/j.1365-2958.2008.06394.x DOI 10.1111/j.1365-2958.2008.06416.x http://dx.doi.org/10.1111/j.1365-2958.2008.06416.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14402 http://www.ecogene.org/geneInfo.php?eg_id=EG14402 EnsemblBacteria ABP93456 http://www.ensemblgenomes.org/id/ABP93456 EnsemblBacteria ABP93456 http://www.ensemblgenomes.org/id/ABP93456 EnsemblBacteria b4618 http://www.ensemblgenomes.org/id/b4618 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0005253 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005253 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0009432 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009432 GO_process GO:0022611 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022611 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 5061527 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5061527 InterPro IPR025211 http://www.ebi.ac.uk/interpro/entry/IPR025211 KEGG_Gene eco:b4618 http://www.genome.jp/dbget-bin/www_bget?eco:b4618 PSORT swissprot:TISB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TISB_ECOLI PSORT-B swissprot:TISB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TISB_ECOLI PSORT2 swissprot:TISB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TISB_ECOLI Pfam PF13939 http://pfam.xfam.org/family/PF13939 Phobius swissprot:TISB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TISB_ECOLI PubMed 15620655 http://www.ncbi.nlm.nih.gov/pubmed/15620655 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17499044 http://www.ncbi.nlm.nih.gov/pubmed/17499044 PubMed 18710431 http://www.ncbi.nlm.nih.gov/pubmed/18710431 PubMed 18761622 http://www.ncbi.nlm.nih.gov/pubmed/18761622 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001054909 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001054909 RefSeq YP_001165331 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001165331 STRING 511145.b4618 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4618&targetmode=cogs TCDB 1.C.103.1 http://www.tcdb.org/search/result.php?tc=1.C.103.1 TIGRFAMs TIGR04459 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR04459 UniProtKB TISB_ECOLI http://www.uniprot.org/uniprot/TISB_ECOLI UniProtKB-AC A5A627 http://www.uniprot.org/uniprot/A5A627 charge swissprot:TISB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TISB_ECOLI epestfind swissprot:TISB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TISB_ECOLI garnier swissprot:TISB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TISB_ECOLI helixturnhelix swissprot:TISB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TISB_ECOLI hmoment swissprot:TISB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TISB_ECOLI iep swissprot:TISB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TISB_ECOLI inforesidue swissprot:TISB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TISB_ECOLI octanol swissprot:TISB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TISB_ECOLI pepcoil swissprot:TISB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TISB_ECOLI pepdigest swissprot:TISB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TISB_ECOLI pepinfo swissprot:TISB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TISB_ECOLI pepnet swissprot:TISB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TISB_ECOLI pepstats swissprot:TISB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TISB_ECOLI pepwheel swissprot:TISB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TISB_ECOLI pepwindow swissprot:TISB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TISB_ECOLI sigcleave swissprot:TISB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TISB_ECOLI ## Database ID URL or Descriptions # EcoGene EG40011 insK # FUNCTION INSK_ECOLI Involved in the transposition of the insertion sequence IS150. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006310 DNA recombination; IEA:UniProtKB-KW. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0015074 DNA integration; IEA:InterPro. # GO_process GO:0032196 transposition; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0032196 transposition # Gene3D 3.30.420.10 -; 1. # IntAct P19769 3 # InterPro IPR001584 Integrase_cat-core # InterPro IPR012337 RNaseH-like_dom # InterPro IPR025948 HTH-like_dom # Organism INSK_ECOLI Escherichia coli (strain K12) # PATRIC 32122590 VBIEscCol129921_3672 # PROSITE PS50994 INTEGRASE # Pfam PF00665 rve # Pfam PF13276 HTH_21 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSK_ECOLI Putative transposase InsK for insertion sequence element IS150 # RefSeq NP_418015 NC_000913.3 # RefSeq WP_000866395 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18535.2; Type=Miscellaneous discrepancy; Note=B-168 has been translated as Asn.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the transposase IS3/IS150/IS904 family. {ECO 0000305}. # SIMILARITY Contains 1 integrase catalytic domain. {ECO:0000255|PROSITE-ProRule PRU00457}. # SUPFAM SSF53098 SSF53098 # eggNOG COG2801 LUCA # eggNOG ENOG4105DQ6 Bacteria BLAST swissprot:INSK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSK_ECOLI BioCyc ECOL316407:JW3528-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3528-MONOMER BioCyc EcoCyc:G7777-MONOMER http://biocyc.org/getid?id=EcoCyc:G7777-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/16.14.6789 http://dx.doi.org/10.1093/nar/16.14.6789 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X07037 http://www.ebi.ac.uk/ena/data/view/X07037 EcoGene EG40011 http://www.ecogene.org/geneInfo.php?eg_id=EG40011 EnsemblBacteria AAC76582 http://www.ensemblgenomes.org/id/AAC76582 EnsemblBacteria AAC76582 http://www.ensemblgenomes.org/id/AAC76582 EnsemblBacteria BAE77736 http://www.ensemblgenomes.org/id/BAE77736 EnsemblBacteria BAE77736 http://www.ensemblgenomes.org/id/BAE77736 EnsemblBacteria BAE77736 http://www.ensemblgenomes.org/id/BAE77736 EnsemblBacteria b3558 http://www.ensemblgenomes.org/id/b3558 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0015074 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015074 GO_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 3.30.420.10 http://www.cathdb.info/version/latest/superfamily/3.30.420.10 GeneID 948081 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948081 HOGENOM HOG000023133 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000023133&db=HOGENOM6 InParanoid P19769 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P19769 IntAct P19769 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P19769* InterPro IPR001584 http://www.ebi.ac.uk/interpro/entry/IPR001584 InterPro IPR012337 http://www.ebi.ac.uk/interpro/entry/IPR012337 InterPro IPR025948 http://www.ebi.ac.uk/interpro/entry/IPR025948 KEGG_Gene ecj:JW3528 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3528 KEGG_Gene eco:b3558 http://www.genome.jp/dbget-bin/www_bget?eco:b3558 OMA MLELRQH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MLELRQH PROSITE PS50994 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50994 PSORT swissprot:INSK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSK_ECOLI PSORT-B swissprot:INSK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSK_ECOLI PSORT2 swissprot:INSK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSK_ECOLI Pfam PF00665 http://pfam.xfam.org/family/PF00665 Pfam PF13276 http://pfam.xfam.org/family/PF13276 Phobius swissprot:INSK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSK_ECOLI PhylomeDB P19769 http://phylomedb.org/?seqid=P19769 ProteinModelPortal P19769 http://www.proteinmodelportal.org/query/uniprot/P19769 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2541046 http://www.ncbi.nlm.nih.gov/pubmed/2541046 PubMed 2841644 http://www.ncbi.nlm.nih.gov/pubmed/2841644 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418015 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418015 RefSeq WP_000866395 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000866395 SMR P19769 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P19769 STRING 511145.b3558 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3558&targetmode=cogs SUPFAM SSF53098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098 UniProtKB INSK_ECOLI http://www.uniprot.org/uniprot/INSK_ECOLI UniProtKB-AC P19769 http://www.uniprot.org/uniprot/P19769 charge swissprot:INSK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSK_ECOLI eggNOG COG2801 http://eggnogapi.embl.de/nog_data/html/tree/COG2801 eggNOG ENOG4105DQ6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DQ6 epestfind swissprot:INSK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSK_ECOLI garnier swissprot:INSK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSK_ECOLI helixturnhelix swissprot:INSK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSK_ECOLI hmoment swissprot:INSK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSK_ECOLI iep swissprot:INSK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSK_ECOLI inforesidue swissprot:INSK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSK_ECOLI octanol swissprot:INSK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSK_ECOLI pepcoil swissprot:INSK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSK_ECOLI pepdigest swissprot:INSK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSK_ECOLI pepinfo swissprot:INSK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSK_ECOLI pepnet swissprot:INSK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSK_ECOLI pepstats swissprot:INSK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSK_ECOLI pepwheel swissprot:INSK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSK_ECOLI pepwindow swissprot:INSK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSK_ECOLI sigcleave swissprot:INSK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSK_ECOLI ## Database ID URL or Descriptions # BioGrid 4259906 6 # EcoGene EG13648 ybeR # IntAct P77627 6 # InterPro IPR009677 DUF1266 # Organism YBER_ECOLI Escherichia coli (strain K12) # PATRIC 32116473 VBIEscCol129921_0676 # PIR C64799 C64799 # Pfam PF06889 DUF1266 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBER_ECOLI Uncharacterized protein YbeR # RefSeq NP_415178 NC_000913.3 # RefSeq WP_000367023 NZ_LN832404.1 # SIMILARITY To E.coli YbeU. {ECO 0000305}. # eggNOG ENOG41069CF Bacteria # eggNOG ENOG410XVCG LUCA BLAST swissprot:YBER_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBER_ECOLI BioCyc ECOL316407:JW0640-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0640-MONOMER BioCyc EcoCyc:G6352-MONOMER http://biocyc.org/getid?id=EcoCyc:G6352-MONOMER DIP DIP-11366N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11366N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB3412 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3412 EcoGene EG13648 http://www.ecogene.org/geneInfo.php?eg_id=EG13648 EnsemblBacteria AAC73746 http://www.ensemblgenomes.org/id/AAC73746 EnsemblBacteria AAC73746 http://www.ensemblgenomes.org/id/AAC73746 EnsemblBacteria BAA35292 http://www.ensemblgenomes.org/id/BAA35292 EnsemblBacteria BAA35292 http://www.ensemblgenomes.org/id/BAA35292 EnsemblBacteria BAA35292 http://www.ensemblgenomes.org/id/BAA35292 EnsemblBacteria b0645 http://www.ensemblgenomes.org/id/b0645 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945249 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945249 HOGENOM HOG000009368 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009368&db=HOGENOM6 InParanoid P77627 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77627 IntAct P77627 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77627* InterPro IPR009677 http://www.ebi.ac.uk/interpro/entry/IPR009677 KEGG_Gene ecj:JW0640 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0640 KEGG_Gene eco:b0645 http://www.genome.jp/dbget-bin/www_bget?eco:b0645 OMA LQYFSAY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LQYFSAY PSORT swissprot:YBER_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBER_ECOLI PSORT-B swissprot:YBER_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBER_ECOLI PSORT2 swissprot:YBER_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBER_ECOLI Pfam PF06889 http://pfam.xfam.org/family/PF06889 Phobius swissprot:YBER_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBER_ECOLI ProteinModelPortal P77627 http://www.proteinmodelportal.org/query/uniprot/P77627 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415178 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415178 RefSeq WP_000367023 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000367023 STRING 511145.b0645 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0645&targetmode=cogs UniProtKB YBER_ECOLI http://www.uniprot.org/uniprot/YBER_ECOLI UniProtKB-AC P77627 http://www.uniprot.org/uniprot/P77627 charge swissprot:YBER_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBER_ECOLI eggNOG ENOG41069CF http://eggnogapi.embl.de/nog_data/html/tree/ENOG41069CF eggNOG ENOG410XVCG http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XVCG epestfind swissprot:YBER_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBER_ECOLI garnier swissprot:YBER_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBER_ECOLI helixturnhelix swissprot:YBER_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBER_ECOLI hmoment swissprot:YBER_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBER_ECOLI iep swissprot:YBER_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBER_ECOLI inforesidue swissprot:YBER_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBER_ECOLI octanol swissprot:YBER_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBER_ECOLI pepcoil swissprot:YBER_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBER_ECOLI pepdigest swissprot:YBER_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBER_ECOLI pepinfo swissprot:YBER_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBER_ECOLI pepnet swissprot:YBER_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBER_ECOLI pepstats swissprot:YBER_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBER_ECOLI pepwheel swissprot:YBER_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBER_ECOLI pepwindow swissprot:YBER_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBER_ECOLI sigcleave swissprot:YBER_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBER_ECOLI ## Database ID URL or Descriptions # AltName THID_ECOLI Hydroxymethylpyrimidine kinase # AltName THID_ECOLI Hydroxymethylpyrimidine phosphate kinase # BRENDA 2.7.1.49 2026 # BioGrid 4261536 7 # CATALYTIC ACTIVITY ATP + 4-amino-2-methyl-5- (phosphooxymethyl)pyrimidine = ADP + 4-amino-2-methyl-5- (diphosphooxymethyl)pyrimidine. {ECO:0000269|PubMed 10075431}. # CATALYTIC ACTIVITY ATP + 4-amino-5-hydroxymethyl-2- methylpyrimidine = ADP + 4-amino-2-methyl-5- (phosphomethyl)pyrimidine. {ECO:0000269|PubMed 10075431}. # CDD cd01169 HMPP_kinase # EcoGene EG14068 thiD # FUNCTION THID_ECOLI Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Shows no activity with pyridoxal, pyridoxamine or pyridoxine. {ECO 0000269|PubMed 10075431}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0008902 hydroxymethylpyrimidine kinase activity; IDA:EcoCyc. # GO_function GO:0008972 phosphomethylpyrimidine kinase activity; IEA:UniProtKB-EC. # GO_process GO:0009228 thiamine biosynthetic process; IMP:EcoCyc. # GO_process GO:0009229 thiamine diphosphate biosynthetic process; IDA:EcoCyc. # GO_process GO:0016310 phosphorylation; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.1190.20 -; 1. # IntAct P76422 7 # InterPro IPR004399 HMP/HMP-P_kinase # InterPro IPR013749 PM/HMP-P_kinase-1 # InterPro IPR029056 Ribokinase-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00730 Thiamine metabolism # Organism THID_ECOLI Escherichia coli (strain K12) # PATHWAY Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5- phospho-D-ribosyl)imidazole step 2/3. # PATHWAY Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5- phospho-D-ribosyl)imidazole step 3/3. # PATRIC 32119539 VBIEscCol129921_2180 # PIR F64977 F64977 # Pfam PF08543 Phos_pyr_kin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName THID_ECOLI Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase # RefSeq NP_416606 NC_000913.3 # RefSeq WP_000822274 NZ_LN832404.1 # SIMILARITY Belongs to the ThiD family. {ECO 0000305}. # SUBUNIT Monomer. {ECO:0000269|PubMed 10075431}. # SUPFAM SSF53613 SSF53613 # TIGRFAMs TIGR00097 HMP-P_kinase # UniPathway UPA00060 UER00137 # UniPathway UPA00060 UER00138 # eggNOG COG0351 LUCA # eggNOG ENOG4105DWF Bacteria BLAST swissprot:THID_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:THID_ECOLI BioCyc ECOL316407:JW2090-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2090-MONOMER BioCyc EcoCyc:HMP-P-KIN-MONOMER http://biocyc.org/getid?id=EcoCyc:HMP-P-KIN-MONOMER BioCyc MetaCyc:HMP-P-KIN-MONOMER http://biocyc.org/getid?id=MetaCyc:HMP-P-KIN-MONOMER COG COG0351 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0351 DIP DIP-6867N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-6867N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1099/13500872-145-2-495 http://dx.doi.org/10.1099/13500872-145-2-495 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.49 {ECO:0000269|PubMed:10075431} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.49 {ECO:0000269|PubMed:10075431} EC_number EC:2.7.4.7 {ECO:0000269|PubMed:10075431} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.4.7 {ECO:0000269|PubMed:10075431} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D84200 http://www.ebi.ac.uk/ena/data/view/D84200 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.49 {ECO:0000269|PubMed:10075431} http://enzyme.expasy.org/EC/2.7.1.49 {ECO:0000269|PubMed:10075431} ENZYME 2.7.4.7 {ECO:0000269|PubMed:10075431} http://enzyme.expasy.org/EC/2.7.4.7 {ECO:0000269|PubMed:10075431} EchoBASE EB3821 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3821 EcoGene EG14068 http://www.ecogene.org/geneInfo.php?eg_id=EG14068 EnsemblBacteria AAC75164 http://www.ensemblgenomes.org/id/AAC75164 EnsemblBacteria AAC75164 http://www.ensemblgenomes.org/id/AAC75164 EnsemblBacteria BAA15971 http://www.ensemblgenomes.org/id/BAA15971 EnsemblBacteria BAA15971 http://www.ensemblgenomes.org/id/BAA15971 EnsemblBacteria BAA15971 http://www.ensemblgenomes.org/id/BAA15971 EnsemblBacteria b2103 http://www.ensemblgenomes.org/id/b2103 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008902 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008902 GO_function GO:0008972 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008972 GO_process GO:0009228 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009228 GO_process GO:0009229 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009229 GO_process GO:0016310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016310 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.1190.20 http://www.cathdb.info/version/latest/superfamily/3.40.1190.20 GeneID 946459 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946459 HOGENOM HOG000225275 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000225275&db=HOGENOM6 InParanoid P76422 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76422 IntAct P76422 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76422* IntEnz 2.7.1.49 {ECO:0000269|PubMed:10075431} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.49 {ECO:0000269|PubMed:10075431} IntEnz 2.7.4.7 {ECO:0000269|PubMed:10075431} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.4.7 {ECO:0000269|PubMed:10075431} InterPro IPR004399 http://www.ebi.ac.uk/interpro/entry/IPR004399 InterPro IPR013749 http://www.ebi.ac.uk/interpro/entry/IPR013749 InterPro IPR029056 http://www.ebi.ac.uk/interpro/entry/IPR029056 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2090 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2090 KEGG_Gene eco:b2103 http://www.genome.jp/dbget-bin/www_bget?eco:b2103 KEGG_Orthology KO:K00941 http://www.genome.jp/dbget-bin/www_bget?KO:K00941 KEGG_Pathway ko00730 http://www.genome.jp/kegg-bin/show_pathway?ko00730 KEGG_Reaction rn:R03471 http://www.genome.jp/dbget-bin/www_bget?rn:R03471 KEGG_Reaction rn:R04509 http://www.genome.jp/dbget-bin/www_bget?rn:R04509 OMA FAFHCVH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FAFHCVH PSORT swissprot:THID_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:THID_ECOLI PSORT-B swissprot:THID_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:THID_ECOLI PSORT2 swissprot:THID_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:THID_ECOLI Pfam PF08543 http://pfam.xfam.org/family/PF08543 Phobius swissprot:THID_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:THID_ECOLI PhylomeDB P76422 http://phylomedb.org/?seqid=P76422 ProteinModelPortal P76422 http://www.proteinmodelportal.org/query/uniprot/P76422 PubMed 10075431 http://www.ncbi.nlm.nih.gov/pubmed/10075431 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416606 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416606 RefSeq WP_000822274 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000822274 SMR P76422 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76422 STRING 511145.b2103 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2103&targetmode=cogs STRING COG0351 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0351&targetmode=cogs SUPFAM SSF53613 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53613 TIGRFAMs TIGR00097 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00097 UniProtKB THID_ECOLI http://www.uniprot.org/uniprot/THID_ECOLI UniProtKB-AC P76422 http://www.uniprot.org/uniprot/P76422 charge swissprot:THID_ECOLI http://rest.g-language.org/emboss/charge/swissprot:THID_ECOLI eggNOG COG0351 http://eggnogapi.embl.de/nog_data/html/tree/COG0351 eggNOG ENOG4105DWF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DWF epestfind swissprot:THID_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:THID_ECOLI garnier swissprot:THID_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:THID_ECOLI helixturnhelix swissprot:THID_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:THID_ECOLI hmoment swissprot:THID_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:THID_ECOLI iep swissprot:THID_ECOLI http://rest.g-language.org/emboss/iep/swissprot:THID_ECOLI inforesidue swissprot:THID_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:THID_ECOLI octanol swissprot:THID_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:THID_ECOLI pepcoil swissprot:THID_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:THID_ECOLI pepdigest swissprot:THID_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:THID_ECOLI pepinfo swissprot:THID_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:THID_ECOLI pepnet swissprot:THID_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:THID_ECOLI pepstats swissprot:THID_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:THID_ECOLI pepwheel swissprot:THID_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:THID_ECOLI pepwindow swissprot:THID_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:THID_ECOLI sigcleave swissprot:THID_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:THID_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES METF_ECOLI Kinetic parameters KM=17 uM for NADPH {ECO 0000269|PubMed 10201405, ECO 0000269|PubMed 14275142}; KM=3.9 uM for 5,10-methylenetetrahydrofolate {ECO 0000269|PubMed 10201405, ECO 0000269|PubMed 14275142}; pH dependence Optimum pH is 6.3-6.4. {ECO 0000269|PubMed 10201405, ECO 0000269|PubMed 14275142}; # BRENDA 1.5.1.20 2026 # BioGrid 4263063 13 # CATALYTIC ACTIVITY METF_ECOLI 5-methyltetrahydrofolate + NAD(P)(+) = 5,10- methylenetetrahydrofolate + NAD(P)H. {ECO 0000269|PubMed 11371182, ECO 0000269|PubMed 14275142, ECO 0000269|PubMed 19610625}. # CDD cd00537 MTHFR # COFACTOR METF_ECOLI Name=FAD; Xref=ChEBI CHEBI 57692; Evidence={ECO 0000269|PubMed 10201405, ECO 0000269|PubMed 11371182, ECO 0000269|PubMed 14275142, ECO 0000269|PubMed 16114881, ECO 0000269|PubMed 16605249, ECO 0000269|PubMed 19610625}; # DrugBank DB03147 Flavin adenine dinucleotide # EcoGene EG10585 metF # FUNCTION METF_ECOLI Methylenetetrahydrofolate reductase required to generate the methyl groups necessary for methionine synthetase to convert homocysteine to methionine. {ECO 0000269|PubMed 14275142}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity; IDA:EcoCyc. # GO_function GO:0071949 FAD binding; IDA:EcoCyc. # GO_process GO:0006730 one-carbon metabolic process; IBA:GO_Central. # GO_process GO:0009086 methionine biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0035999 tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway. # GO_process GO:0046654 tetrahydrofolate biosynthetic process; IDA:EcoCyc. # GO_process GO:0051289 protein homotetramerization; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.20.20.220 -; 1. # INDUCTION Repressed by methionine. {ECO:0000269|PubMed 14275142}. # IntAct P0AEZ1 4 # InterPro IPR003171 Mehydrof_redctse # InterPro IPR004620 MTHF_reductase_bac # InterPro IPR029041 FAD-linked_oxidoreductase-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00670 One carbon pool by folate # KEGG_Pathway ko00680 Methane metabolism # KEGG_Pathway ko00720 Carbon fixation pathways in prokaryotes # Organism METF_ECOLI Escherichia coli (strain K12) # PATHWAY METF_ECOLI One-carbon metabolism; tetrahydrofolate interconversion. # PATRIC 32123403 VBIEscCol129921_4062 # PDB 1B5T X-ray; 2.50 A; A/B/C=21-294 # PDB 1ZP3 X-ray; 1.85 A; A/B/C=1-296 # PDB 1ZP4 X-ray; 1.85 A; A/B/C=1-296 # PDB 1ZPT X-ray; 1.95 A; A/B/C=1-296 # PDB 1ZRQ X-ray; 2.20 A; A/B/C=1-296 # PDB 2FMN X-ray; 2.05 A; A/B/C=1-296 # PDB 2FMO X-ray; 2.25 A; A/B/C=1-296 # PDB 3FST X-ray; 1.65 A; A/C/E=1-296 # PDB 3FSU X-ray; 1.70 A; A/C/E=1-296 # PIR A00462 RDECMH # Pfam PF02219 MTHFR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName METF_ECOLI 5,10-methylenetetrahydrofolate reductase # RefSeq NP_418376 NC_000913.3 # RefSeq WP_000007523 NZ_LN832404.1 # SIMILARITY Belongs to the methylenetetrahydrofolate reductase family. {ECO 0000305}. # SUBUNIT METF_ECOLI Homotetramer. {ECO 0000269|PubMed 10201405, ECO 0000269|PubMed 16114881, ECO 0000269|PubMed 16605249}. # SUPFAM SSF51730 SSF51730 # TIGRFAMs TIGR00676 fadh2 # eggNOG COG0685 LUCA # eggNOG ENOG4105SYT Bacteria BLAST swissprot:METF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:METF_ECOLI BioCyc ECOL316407:JW3913-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3913-MONOMER BioCyc EcoCyc:METHYLENETHFREDUCT-MONOMER http://biocyc.org/getid?id=EcoCyc:METHYLENETHFREDUCT-MONOMER BioCyc MetaCyc:METHYLENETHFREDUCT-MONOMER http://biocyc.org/getid?id=MetaCyc:METHYLENETHFREDUCT-MONOMER COG COG0685 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0685 DIP DIP-6848N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-6848N DOI 10.1007/BF00384390 http://dx.doi.org/10.1007/BF00384390 DOI 10.1021/bi002790v http://dx.doi.org/10.1021/bi002790v DOI 10.1021/bi050533q http://dx.doi.org/10.1021/bi050533q DOI 10.1021/bi052294c http://dx.doi.org/10.1021/bi052294c DOI 10.1021/bi9007325 http://dx.doi.org/10.1021/bi9007325 DOI 10.1038/7594 http://dx.doi.org/10.1038/7594 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/11.19.6723 http://dx.doi.org/10.1093/nar/11.19.6723 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB03147 http://www.drugbank.ca/drugs/DB03147 EC_number EC:1.5.1.20 http://www.genome.jp/dbget-bin/www_bget?EC:1.5.1.20 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V01502 http://www.ebi.ac.uk/ena/data/view/V01502 ENZYME 1.5.1.20 http://enzyme.expasy.org/EC/1.5.1.20 EchoBASE EB0580 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0580 EcoGene EG10585 http://www.ecogene.org/geneInfo.php?eg_id=EG10585 EnsemblBacteria AAC76923 http://www.ensemblgenomes.org/id/AAC76923 EnsemblBacteria AAC76923 http://www.ensemblgenomes.org/id/AAC76923 EnsemblBacteria BAE77369 http://www.ensemblgenomes.org/id/BAE77369 EnsemblBacteria BAE77369 http://www.ensemblgenomes.org/id/BAE77369 EnsemblBacteria BAE77369 http://www.ensemblgenomes.org/id/BAE77369 EnsemblBacteria b3941 http://www.ensemblgenomes.org/id/b3941 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004489 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004489 GO_function GO:0071949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071949 GO_process GO:0006730 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006730 GO_process GO:0009086 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009086 GO_process GO:0035999 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035999 GO_process GO:0046654 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046654 GO_process GO:0051289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051289 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.20.20.220 http://www.cathdb.info/version/latest/superfamily/3.20.20.220 GeneID 948432 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948432 HOGENOM HOG000246232 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000246232&db=HOGENOM6 InParanoid P0AEZ1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEZ1 IntAct P0AEZ1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEZ1* IntEnz 1.5.1.20 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.5.1.20 InterPro IPR003171 http://www.ebi.ac.uk/interpro/entry/IPR003171 InterPro IPR004620 http://www.ebi.ac.uk/interpro/entry/IPR004620 InterPro IPR029041 http://www.ebi.ac.uk/interpro/entry/IPR029041 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3913 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3913 KEGG_Gene eco:b3941 http://www.genome.jp/dbget-bin/www_bget?eco:b3941 KEGG_Orthology KO:K00297 http://www.genome.jp/dbget-bin/www_bget?KO:K00297 KEGG_Pathway ko00670 http://www.genome.jp/kegg-bin/show_pathway?ko00670 KEGG_Pathway ko00680 http://www.genome.jp/kegg-bin/show_pathway?ko00680 KEGG_Pathway ko00720 http://www.genome.jp/kegg-bin/show_pathway?ko00720 KEGG_Reaction rn:R01224 http://www.genome.jp/dbget-bin/www_bget?rn:R01224 KEGG_Reaction rn:R07168 http://www.genome.jp/dbget-bin/www_bget?rn:R07168 OMA EMHPQAR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EMHPQAR PDB 1B5T http://www.ebi.ac.uk/pdbe-srv/view/entry/1B5T PDB 1ZP3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZP3 PDB 1ZP4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZP4 PDB 1ZPT http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZPT PDB 1ZRQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZRQ PDB 2FMN http://www.ebi.ac.uk/pdbe-srv/view/entry/2FMN PDB 2FMO http://www.ebi.ac.uk/pdbe-srv/view/entry/2FMO PDB 3FST http://www.ebi.ac.uk/pdbe-srv/view/entry/3FST PDB 3FSU http://www.ebi.ac.uk/pdbe-srv/view/entry/3FSU PDBsum 1B5T http://www.ebi.ac.uk/pdbsum/1B5T PDBsum 1ZP3 http://www.ebi.ac.uk/pdbsum/1ZP3 PDBsum 1ZP4 http://www.ebi.ac.uk/pdbsum/1ZP4 PDBsum 1ZPT http://www.ebi.ac.uk/pdbsum/1ZPT PDBsum 1ZRQ http://www.ebi.ac.uk/pdbsum/1ZRQ PDBsum 2FMN http://www.ebi.ac.uk/pdbsum/2FMN PDBsum 2FMO http://www.ebi.ac.uk/pdbsum/2FMO PDBsum 3FST http://www.ebi.ac.uk/pdbsum/3FST PDBsum 3FSU http://www.ebi.ac.uk/pdbsum/3FSU PSORT swissprot:METF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:METF_ECOLI PSORT-B swissprot:METF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:METF_ECOLI PSORT2 swissprot:METF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:METF_ECOLI Pfam PF02219 http://pfam.xfam.org/family/PF02219 Phobius swissprot:METF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:METF_ECOLI PhylomeDB P0AEZ1 http://phylomedb.org/?seqid=P0AEZ1 ProteinModelPortal P0AEZ1 http://www.proteinmodelportal.org/query/uniprot/P0AEZ1 PubMed 10201405 http://www.ncbi.nlm.nih.gov/pubmed/10201405 PubMed 11371182 http://www.ncbi.nlm.nih.gov/pubmed/11371182 PubMed 14275142 http://www.ncbi.nlm.nih.gov/pubmed/14275142 PubMed 16114881 http://www.ncbi.nlm.nih.gov/pubmed/16114881 PubMed 16605249 http://www.ncbi.nlm.nih.gov/pubmed/16605249 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19610625 http://www.ncbi.nlm.nih.gov/pubmed/19610625 PubMed 6219268 http://www.ncbi.nlm.nih.gov/pubmed/6219268 PubMed 6356036 http://www.ncbi.nlm.nih.gov/pubmed/6356036 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418376 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418376 RefSeq WP_000007523 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000007523 SMR P0AEZ1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEZ1 STRING 511145.b3941 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3941&targetmode=cogs STRING COG0685 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0685&targetmode=cogs SUPFAM SSF51730 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51730 TIGRFAMs TIGR00676 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00676 UniProtKB METF_ECOLI http://www.uniprot.org/uniprot/METF_ECOLI UniProtKB-AC P0AEZ1 http://www.uniprot.org/uniprot/P0AEZ1 charge swissprot:METF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:METF_ECOLI eggNOG COG0685 http://eggnogapi.embl.de/nog_data/html/tree/COG0685 eggNOG ENOG4105SYT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105SYT epestfind swissprot:METF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:METF_ECOLI garnier swissprot:METF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:METF_ECOLI helixturnhelix swissprot:METF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:METF_ECOLI hmoment swissprot:METF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:METF_ECOLI iep swissprot:METF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:METF_ECOLI inforesidue swissprot:METF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:METF_ECOLI octanol swissprot:METF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:METF_ECOLI pepcoil swissprot:METF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:METF_ECOLI pepdigest swissprot:METF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:METF_ECOLI pepinfo swissprot:METF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:METF_ECOLI pepnet swissprot:METF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:METF_ECOLI pepstats swissprot:METF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:METF_ECOLI pepwheel swissprot:METF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:METF_ECOLI pepwindow swissprot:METF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:METF_ECOLI sigcleave swissprot:METF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:METF_ECOLI ## Database ID URL or Descriptions # AltName YBGA_ECOLI ORF169 # AltName YBGA_ECOLI TKP # BioGrid 4261605 12 # EcoGene EG11108 ybgA # IntAct P24252 6 # InterPro IPR013560 DUF1722 # Organism YBGA_ECOLI Escherichia coli (strain K12) # PATRIC 32116609 VBIEscCol129921_0737 # PIR B64806 B64806 # Pfam PF08349 DUF1722 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBGA_ECOLI Uncharacterized protein YbgA # RefSeq NP_415235 NC_000913.3 # RefSeq WP_001053305 NZ_LN832404.1 # eggNOG COG3272 LUCA # eggNOG ENOG4107SEY Bacteria BLAST swissprot:YBGA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBGA_ECOLI BioCyc ECOL316407:JW0697-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0697-MONOMER BioCyc EcoCyc:EG11108-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11108-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K01299 http://www.ebi.ac.uk/ena/data/view/K01299 EMBL L02373 http://www.ebi.ac.uk/ena/data/view/L02373 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1099 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1099 EcoGene EG11108 http://www.ecogene.org/geneInfo.php?eg_id=EG11108 EnsemblBacteria AAC73801 http://www.ensemblgenomes.org/id/AAC73801 EnsemblBacteria AAC73801 http://www.ensemblgenomes.org/id/AAC73801 EnsemblBacteria BAA35366 http://www.ensemblgenomes.org/id/BAA35366 EnsemblBacteria BAA35366 http://www.ensemblgenomes.org/id/BAA35366 EnsemblBacteria BAA35366 http://www.ensemblgenomes.org/id/BAA35366 EnsemblBacteria b0707 http://www.ensemblgenomes.org/id/b0707 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 944853 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944853 HOGENOM HOG000117990 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117990&db=HOGENOM6 IntAct P24252 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P24252* InterPro IPR013560 http://www.ebi.ac.uk/interpro/entry/IPR013560 KEGG_Gene ecj:JW0697 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0697 KEGG_Gene eco:b0707 http://www.genome.jp/dbget-bin/www_bget?eco:b0707 OMA HPANTRD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HPANTRD PSORT swissprot:YBGA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBGA_ECOLI PSORT-B swissprot:YBGA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBGA_ECOLI PSORT2 swissprot:YBGA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBGA_ECOLI Pfam PF08349 http://pfam.xfam.org/family/PF08349 Phobius swissprot:YBGA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBGA_ECOLI PhylomeDB P24252 http://phylomedb.org/?seqid=P24252 ProteinModelPortal P24252 http://www.proteinmodelportal.org/query/uniprot/P24252 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6325460 http://www.ncbi.nlm.nih.gov/pubmed/6325460 PubMed 8387990 http://www.ncbi.nlm.nih.gov/pubmed/8387990 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415235 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415235 RefSeq WP_001053305 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001053305 STRING 511145.b0707 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0707&targetmode=cogs UniProtKB YBGA_ECOLI http://www.uniprot.org/uniprot/YBGA_ECOLI UniProtKB-AC P24252 http://www.uniprot.org/uniprot/P24252 charge swissprot:YBGA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBGA_ECOLI eggNOG COG3272 http://eggnogapi.embl.de/nog_data/html/tree/COG3272 eggNOG ENOG4107SEY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107SEY epestfind swissprot:YBGA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBGA_ECOLI garnier swissprot:YBGA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBGA_ECOLI helixturnhelix swissprot:YBGA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBGA_ECOLI hmoment swissprot:YBGA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBGA_ECOLI iep swissprot:YBGA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBGA_ECOLI inforesidue swissprot:YBGA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBGA_ECOLI octanol swissprot:YBGA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBGA_ECOLI pepcoil swissprot:YBGA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBGA_ECOLI pepdigest swissprot:YBGA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBGA_ECOLI pepinfo swissprot:YBGA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBGA_ECOLI pepnet swissprot:YBGA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBGA_ECOLI pepstats swissprot:YBGA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBGA_ECOLI pepwheel swissprot:YBGA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBGA_ECOLI pepwindow swissprot:YBGA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBGA_ECOLI sigcleave swissprot:YBGA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBGA_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES AROE_ECOLI Kinetic parameters KM=56 uM for NADP {ECO 0000269|PubMed 12637497}; KM=65 uM for shikimate {ECO 0000269|PubMed 12637497}; Note=Kcat is 14.2 min(-1) for dehydrogenase activity with NADP or shikimate. {ECO 0000269|PubMed 12637497}; # BioGrid 4261870 136 # CATALYTIC ACTIVITY AROE_ECOLI Shikimate + NADP(+) = 3-dehydroshikimate + NADPH. {ECO 0000255|HAMAP-Rule MF_00222, ECO 0000269|PubMed 12637497}. # EcoGene EG10077 aroE # FUNCTION AROE_ECOLI Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). It displays no activity in the presence of NAD. {ECO 0000255|HAMAP-Rule MF_00222, ECO 0000269|PubMed 12637497, ECO 0000269|PubMed 3883995}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000166 nucleotide binding; IDA:EcoCyc. # GO_function GO:0004764 shikimate 3-dehydrogenase (NADP+) activity; IDA:EcoCyc. # GO_function GO:0050661 NADP binding; IDA:EcoCyc. # GO_process GO:0008652 cellular amino acid biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0009073 aromatic amino acid family biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0009423 chorismate biosynthetic process; IDA:EcoCyc. # GO_process GO:0019632 shikimate metabolic process; IDA:UniProtKB. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.720 -; 1. # HAMAP MF_00222 Shikimate_DH_AroE # IntAct P15770 6 # InterPro IPR006151 Shikm_DH/Glu-tRNA_Rdtase # InterPro IPR011342 Shikimate_DH # InterPro IPR013708 Shikimate_DH-bd_N # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR022893 Shikimate_DH_fam # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis # Organism AROE_ECOLI Escherichia coli (strain K12) # PATHWAY Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. {ECO 0000255|HAMAP-Rule:MF_00222}. # PATRIC 32121996 VBIEscCol129921_3375 # PDB 1NYT X-ray; 1.50 A; A/B/C/D=1-271 # PIR S00252 S00252 # Pfam PF01488 Shikimate_DH # Pfam PF08501 Shikimate_dh_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Shikimate dehydrogenase (NADP(+)) {ECO:0000303|PubMed 3883995} # RefSeq NP_417740 NC_000913.3 # RefSeq WP_000451243 NZ_LN832404.1 # SIMILARITY Belongs to the shikimate dehydrogenase family. {ECO:0000255|HAMAP-Rule MF_00222}. # SUBUNIT AROE_ECOLI Monomer or homodimer. {ECO 0000255|HAMAP-Rule MF_00222, ECO 0000269|PubMed 12637497, ECO 0000269|PubMed 3883995}. # SUPFAM SSF51735 SSF51735 # TIGRFAMs TIGR00507 aroE # UniPathway UPA00053 UER00087 # eggNOG COG0169 LUCA # eggNOG ENOG4105E2X Bacteria BLAST swissprot:AROE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AROE_ECOLI BioCyc ECOL316407:JW3242-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3242-MONOMER BioCyc EcoCyc:AROE-MONOMER http://biocyc.org/getid?id=EcoCyc:AROE-MONOMER BioCyc MetaCyc:AROE-MONOMER http://biocyc.org/getid?id=MetaCyc:AROE-MONOMER COG COG0169 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0169 DIP DIP-9153N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9153N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2260217 http://dx.doi.org/10.1042/bj2260217 DOI 10.1042/bj2490319 http://dx.doi.org/10.1042/bj2490319 DOI 10.1074/jbc.M300794200 http://dx.doi.org/10.1074/jbc.M300794200 DOI 10.1107/S0907444900002377 http://dx.doi.org/10.1107/S0907444900002377 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.25 {ECO:0000269|PubMed:12637497} http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.25 {ECO:0000269|PubMed:12637497} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL Y00710 http://www.ebi.ac.uk/ena/data/view/Y00710 ENZYME 1.1.1.25 {ECO:0000269|PubMed:12637497} http://enzyme.expasy.org/EC/1.1.1.25 {ECO:0000269|PubMed:12637497} EchoBASE EB0075 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0075 EcoGene EG10077 http://www.ecogene.org/geneInfo.php?eg_id=EG10077 EnsemblBacteria AAC76306 http://www.ensemblgenomes.org/id/AAC76306 EnsemblBacteria AAC76306 http://www.ensemblgenomes.org/id/AAC76306 EnsemblBacteria BAE78010 http://www.ensemblgenomes.org/id/BAE78010 EnsemblBacteria BAE78010 http://www.ensemblgenomes.org/id/BAE78010 EnsemblBacteria BAE78010 http://www.ensemblgenomes.org/id/BAE78010 EnsemblBacteria b3281 http://www.ensemblgenomes.org/id/b3281 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000166 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000166 GO_function GO:0004764 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004764 GO_function GO:0050661 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050661 GO_process GO:0008652 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008652 GO_process GO:0009073 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009073 GO_process GO:0009423 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009423 GO_process GO:0019632 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019632 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 947776 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947776 HAMAP MF_00222 http://hamap.expasy.org/unirule/MF_00222 HOGENOM HOG000237876 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000237876&db=HOGENOM6 InParanoid P15770 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P15770 IntAct P15770 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P15770* IntEnz 1.1.1.25 {ECO:0000269|PubMed:12637497} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.25 {ECO:0000269|PubMed:12637497} InterPro IPR006151 http://www.ebi.ac.uk/interpro/entry/IPR006151 InterPro IPR011342 http://www.ebi.ac.uk/interpro/entry/IPR011342 InterPro IPR013708 http://www.ebi.ac.uk/interpro/entry/IPR013708 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR022893 http://www.ebi.ac.uk/interpro/entry/IPR022893 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3242 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3242 KEGG_Gene eco:b3281 http://www.genome.jp/dbget-bin/www_bget?eco:b3281 KEGG_Orthology KO:K00014 http://www.genome.jp/dbget-bin/www_bget?KO:K00014 KEGG_Pathway ko00400 http://www.genome.jp/kegg-bin/show_pathway?ko00400 KEGG_Reaction rn:R02413 http://www.genome.jp/dbget-bin/www_bget?rn:R02413 MINT MINT-1246863 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1246863 OMA FGNPIKH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FGNPIKH PDB 1NYT http://www.ebi.ac.uk/pdbe-srv/view/entry/1NYT PDBsum 1NYT http://www.ebi.ac.uk/pdbsum/1NYT PSORT swissprot:AROE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AROE_ECOLI PSORT-B swissprot:AROE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AROE_ECOLI PSORT2 swissprot:AROE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AROE_ECOLI Pfam PF01488 http://pfam.xfam.org/family/PF01488 Pfam PF08501 http://pfam.xfam.org/family/PF08501 Phobius swissprot:AROE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AROE_ECOLI PhylomeDB P15770 http://phylomedb.org/?seqid=P15770 ProteinModelPortal P15770 http://www.proteinmodelportal.org/query/uniprot/P15770 PubMed 10739937 http://www.ncbi.nlm.nih.gov/pubmed/10739937 PubMed 12637497 http://www.ncbi.nlm.nih.gov/pubmed/12637497 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3277621 http://www.ncbi.nlm.nih.gov/pubmed/3277621 PubMed 3883995 http://www.ncbi.nlm.nih.gov/pubmed/3883995 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417740 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417740 RefSeq WP_000451243 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000451243 SMR P15770 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P15770 STRING 511145.b3281 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3281&targetmode=cogs STRING COG0169 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0169&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 TIGRFAMs TIGR00507 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00507 UniProtKB AROE_ECOLI http://www.uniprot.org/uniprot/AROE_ECOLI UniProtKB-AC P15770 http://www.uniprot.org/uniprot/P15770 charge swissprot:AROE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AROE_ECOLI eggNOG COG0169 http://eggnogapi.embl.de/nog_data/html/tree/COG0169 eggNOG ENOG4105E2X http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E2X epestfind swissprot:AROE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AROE_ECOLI garnier swissprot:AROE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AROE_ECOLI helixturnhelix swissprot:AROE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AROE_ECOLI hmoment swissprot:AROE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AROE_ECOLI iep swissprot:AROE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AROE_ECOLI inforesidue swissprot:AROE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AROE_ECOLI octanol swissprot:AROE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AROE_ECOLI pepcoil swissprot:AROE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AROE_ECOLI pepdigest swissprot:AROE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AROE_ECOLI pepinfo swissprot:AROE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AROE_ECOLI pepnet swissprot:AROE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AROE_ECOLI pepstats swissprot:AROE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AROE_ECOLI pepwheel swissprot:AROE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AROE_ECOLI pepwindow swissprot:AROE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AROE_ECOLI sigcleave swissprot:AROE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AROE_ECOLI ## Database ID URL or Descriptions # AltName PTHP_ECOLI Histidine-containing protein # BioGrid 4259700 557 # CATALYTIC ACTIVITY PTHP_ECOLI Protein HPr N(pi)-phospho-L-histidine + protein EIIA = protein HPr + protein EIIA N(tau)-phospho-L- histidine. # CDD cd00367 PTS-HPr_like # EcoGene EG10788 ptsH # FUNCTION PTHP_ECOLI General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the permease (enzymes II/III). # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0019197 phosphoenolpyruvate-dependent sugar phosphotransferase complex; IDA:EcoCyc. # GO_function GO:0004674 protein serine/threonine kinase activity; IEA:UniProtKB-KW. # GO_function GO:0008047 enzyme activator activity; IDA:EcoliWiki. # GO_function GO:0008965 phosphoenolpyruvate-protein phosphotransferase activity; IDA:EcoCyc. # GO_function GO:0016301 kinase activity; IDA:EcoCyc. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IDA:EcoCyc. # GO_process GO:0045819 positive regulation of glycogen catabolic process; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0030234 enzyme regulator activity # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # Gene3D 3.30.1340.10 -; 1. # INTERACTION PTHP_ECOLI P11989 bglG; NbExp=5; IntAct=EBI-902853, EBI-545674; P08839 ptsI; NbExp=2; IntAct=EBI-902853, EBI-551533; # IntAct P0AA04 7 # InterPro IPR000032 HPr-like # InterPro IPR001020 PTS_HPr_His_P_site # InterPro IPR002114 PTS_HPr_Ser_P_site # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02060 Phosphotransferase system (PTS) # Organism PTHP_ECOLI Escherichia coli (strain K12) # PATRIC 32120213 VBIEscCol129921_2509 # PDB 1CM2 X-ray; 1.80 A; A=1-85 # PDB 1CM3 X-ray; 1.60 A; A=1-85 # PDB 1GGR NMR; -; B=1-85 # PDB 1HDN NMR; -; A=1-85 # PDB 1J6T NMR; -; B=1-85 # PDB 1OPD X-ray; 1.50 A; A=1-85 # PDB 1PFH NMR; -; A=1-85 # PDB 1POH X-ray; 2.00 A; A=1-85 # PDB 1VRC NMR; -; C/D=1-85 # PDB 2JEL X-ray; 2.50 A; P=1-85 # PDB 2LRK NMR; -; D=1-85 # PDB 2LRL NMR; -; D=1-85 # PDB 2XDF NMR; -; C/D=1-85 # PDB 3CCD X-ray; 1.00 A; A/B=1-85 # PDB 3EZA NMR; -; B=1-85 # PDB 3EZB NMR; -; B=1-85 # PDB 3EZE NMR; -; B=1-85 # PDB 4XWJ X-ray; 2.10 A; B=1-85 # PIR A29785 WQECPH # PRINTS PR00107 PHOSPHOCPHPR # PROSITE PS00369 PTS_HPR_HIS # PROSITE PS00589 PTS_HPR_SER # PROSITE PS51350 PTS_HPR_DOM # Pfam PF00381 PTS-HPr # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PTHP_ECOLI Phosphocarrier protein HPr # RefSeq NP_416910 NC_000913.3 # RefSeq WP_000487600 NZ_LN832404.1 # SIMILARITY Belongs to the HPr family. {ECO 0000305}. # SIMILARITY Contains 1 HPr domain. {ECO:0000255|PROSITE- ProRule PRU00681}. # SUBCELLULAR LOCATION PTHP_ECOLI Cytoplasm. # SUPFAM SSF55594 SSF55594 # TCDB 8.A.8.1 the phosphotransferase system hpr (hpr) family # TIGRFAMs TIGR01003 PTS_HPr_family # eggNOG COG1925 LUCA BLAST swissprot:PTHP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTHP_ECOLI BioCyc ECOL316407:JW2408-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2408-MONOMER BioCyc EcoCyc:PTSH-MONOMER http://biocyc.org/getid?id=EcoCyc:PTSH-MONOMER BioCyc MetaCyc:PTSH-MONOMER http://biocyc.org/getid?id=MetaCyc:PTSH-MONOMER COG COG1925 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1925 DIP DIP-35731N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35731N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1002/pro.5560050305 http://dx.doi.org/10.1002/pro.5560050305 DOI 10.1006/jmbi.1994.0075 http://dx.doi.org/10.1006/jmbi.1994.0075 DOI 10.1006/jmbi.1994.1254 http://dx.doi.org/10.1006/jmbi.1994.1254 DOI 10.1016/0378-1119(85)90172-6 http://dx.doi.org/10.1016/0378-1119(85)90172-6 DOI 10.1021/bi00115a014 http://dx.doi.org/10.1021/bi00115a014 DOI 10.1021/bi00371a073 http://dx.doi.org/10.1021/bi00371a073 DOI 10.1021/bi00487a026 http://dx.doi.org/10.1021/bi00487a026 DOI 10.1021/bi9603480 http://dx.doi.org/10.1021/bi9603480 DOI 10.1038/5854 http://dx.doi.org/10.1038/5854 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1432-1033.1992.tb17492.x http://dx.doi.org/10.1111/j.1432-1033.1992.tb17492.x DOI 10.1111/j.1574-6968.1998.tb13343.x http://dx.doi.org/10.1111/j.1574-6968.1998.tb13343.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.11.- http://www.genome.jp/dbget-bin/www_bget?EC:2.7.11.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J02796 http://www.ebi.ac.uk/ena/data/view/J02796 EMBL M10425 http://www.ebi.ac.uk/ena/data/view/M10425 EMBL M21451 http://www.ebi.ac.uk/ena/data/view/M21451 EMBL M21994 http://www.ebi.ac.uk/ena/data/view/M21994 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.11.- http://enzyme.expasy.org/EC/2.7.11.- EchoBASE EB0781 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0781 EcoGene EG10788 http://www.ecogene.org/geneInfo.php?eg_id=EG10788 EnsemblBacteria AAC75468 http://www.ensemblgenomes.org/id/AAC75468 EnsemblBacteria AAC75468 http://www.ensemblgenomes.org/id/AAC75468 EnsemblBacteria BAA16289 http://www.ensemblgenomes.org/id/BAA16289 EnsemblBacteria BAA16289 http://www.ensemblgenomes.org/id/BAA16289 EnsemblBacteria BAA16289 http://www.ensemblgenomes.org/id/BAA16289 EnsemblBacteria b2415 http://www.ensemblgenomes.org/id/b2415 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0019197 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019197 GO_function GO:0004674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004674 GO_function GO:0008047 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008047 GO_function GO:0008965 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008965 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GO_process GO:0045819 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045819 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.30.1340.10 http://www.cathdb.info/version/latest/superfamily/3.30.1340.10 GeneID 5550362 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5550362 GeneID 946886 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946886 HOGENOM HOG000278399 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278399&db=HOGENOM6 InParanoid P0AA04 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AA04 IntAct P0AA04 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AA04* IntEnz 2.7.11 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.11 InterPro IPR000032 http://www.ebi.ac.uk/interpro/entry/IPR000032 InterPro IPR001020 http://www.ebi.ac.uk/interpro/entry/IPR001020 InterPro IPR002114 http://www.ebi.ac.uk/interpro/entry/IPR002114 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2408 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2408 KEGG_Gene eco:b2415 http://www.genome.jp/dbget-bin/www_bget?eco:b2415 KEGG_Orthology KO:K02784 http://www.genome.jp/dbget-bin/www_bget?KO:K02784 KEGG_Pathway ko02060 http://www.genome.jp/kegg-bin/show_pathway?ko02060 MINT MINT-8085981 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8085981 OMA EKQAVEH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EKQAVEH PDB 1CM2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1CM2 PDB 1CM3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1CM3 PDB 1GGR http://www.ebi.ac.uk/pdbe-srv/view/entry/1GGR PDB 1HDN http://www.ebi.ac.uk/pdbe-srv/view/entry/1HDN PDB 1J6T http://www.ebi.ac.uk/pdbe-srv/view/entry/1J6T PDB 1OPD http://www.ebi.ac.uk/pdbe-srv/view/entry/1OPD PDB 1PFH http://www.ebi.ac.uk/pdbe-srv/view/entry/1PFH PDB 1POH http://www.ebi.ac.uk/pdbe-srv/view/entry/1POH PDB 1VRC http://www.ebi.ac.uk/pdbe-srv/view/entry/1VRC PDB 2JEL http://www.ebi.ac.uk/pdbe-srv/view/entry/2JEL PDB 2LRK http://www.ebi.ac.uk/pdbe-srv/view/entry/2LRK PDB 2LRL http://www.ebi.ac.uk/pdbe-srv/view/entry/2LRL PDB 2XDF http://www.ebi.ac.uk/pdbe-srv/view/entry/2XDF PDB 3CCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3CCD PDB 3EZA http://www.ebi.ac.uk/pdbe-srv/view/entry/3EZA PDB 3EZB http://www.ebi.ac.uk/pdbe-srv/view/entry/3EZB PDB 3EZE http://www.ebi.ac.uk/pdbe-srv/view/entry/3EZE PDB 4XWJ http://www.ebi.ac.uk/pdbe-srv/view/entry/4XWJ PDBsum 1CM2 http://www.ebi.ac.uk/pdbsum/1CM2 PDBsum 1CM3 http://www.ebi.ac.uk/pdbsum/1CM3 PDBsum 1GGR http://www.ebi.ac.uk/pdbsum/1GGR PDBsum 1HDN http://www.ebi.ac.uk/pdbsum/1HDN PDBsum 1J6T http://www.ebi.ac.uk/pdbsum/1J6T PDBsum 1OPD http://www.ebi.ac.uk/pdbsum/1OPD PDBsum 1PFH http://www.ebi.ac.uk/pdbsum/1PFH PDBsum 1POH http://www.ebi.ac.uk/pdbsum/1POH PDBsum 1VRC http://www.ebi.ac.uk/pdbsum/1VRC PDBsum 2JEL http://www.ebi.ac.uk/pdbsum/2JEL PDBsum 2LRK http://www.ebi.ac.uk/pdbsum/2LRK PDBsum 2LRL http://www.ebi.ac.uk/pdbsum/2LRL PDBsum 2XDF http://www.ebi.ac.uk/pdbsum/2XDF PDBsum 3CCD http://www.ebi.ac.uk/pdbsum/3CCD PDBsum 3EZA http://www.ebi.ac.uk/pdbsum/3EZA PDBsum 3EZB http://www.ebi.ac.uk/pdbsum/3EZB PDBsum 3EZE http://www.ebi.ac.uk/pdbsum/3EZE PDBsum 4XWJ http://www.ebi.ac.uk/pdbsum/4XWJ PRINTS PR00107 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00107 PROSITE PS00369 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00369 PROSITE PS00589 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00589 PROSITE PS51350 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51350 PSORT swissprot:PTHP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTHP_ECOLI PSORT-B swissprot:PTHP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTHP_ECOLI PSORT2 swissprot:PTHP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTHP_ECOLI Pfam PF00381 http://pfam.xfam.org/family/PF00381 Phobius swissprot:PTHP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTHP_ECOLI PhylomeDB P0AA04 http://phylomedb.org/?seqid=P0AA04 ProteinModelPortal P0AA04 http://www.proteinmodelportal.org/query/uniprot/P0AA04 PubMed 10048929 http://www.ncbi.nlm.nih.gov/pubmed/10048929 PubMed 1483471 http://www.ncbi.nlm.nih.gov/pubmed/1483471 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1751501 http://www.ncbi.nlm.nih.gov/pubmed/1751501 PubMed 2261470 http://www.ncbi.nlm.nih.gov/pubmed/2261470 PubMed 2411636 http://www.ncbi.nlm.nih.gov/pubmed/2411636 PubMed 2457575 http://www.ncbi.nlm.nih.gov/pubmed/2457575 PubMed 2960675 http://www.ncbi.nlm.nih.gov/pubmed/2960675 PubMed 3290198 http://www.ncbi.nlm.nih.gov/pubmed/3290198 PubMed 3542036 http://www.ncbi.nlm.nih.gov/pubmed/3542036 PubMed 7853396 http://www.ncbi.nlm.nih.gov/pubmed/7853396 PubMed 8158637 http://www.ncbi.nlm.nih.gov/pubmed/8158637 PubMed 8226757 http://www.ncbi.nlm.nih.gov/pubmed/8226757 PubMed 8784179 http://www.ncbi.nlm.nih.gov/pubmed/8784179 PubMed 8868480 http://www.ncbi.nlm.nih.gov/pubmed/8868480 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9868784 http://www.ncbi.nlm.nih.gov/pubmed/9868784 RefSeq NP_416910 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416910 RefSeq WP_000487600 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000487600 SMR P0AA04 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AA04 STRING 511145.b2415 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2415&targetmode=cogs STRING COG1925 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1925&targetmode=cogs SUPFAM SSF55594 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55594 SWISS-2DPAGE P0AA04 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AA04 TCDB 8.A.8.1 http://www.tcdb.org/search/result.php?tc=8.A.8.1 TIGRFAMs TIGR01003 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01003 UniProtKB PTHP_ECOLI http://www.uniprot.org/uniprot/PTHP_ECOLI UniProtKB-AC P0AA04 http://www.uniprot.org/uniprot/P0AA04 charge swissprot:PTHP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTHP_ECOLI eggNOG COG1925 http://eggnogapi.embl.de/nog_data/html/tree/COG1925 epestfind swissprot:PTHP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTHP_ECOLI garnier swissprot:PTHP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTHP_ECOLI helixturnhelix swissprot:PTHP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTHP_ECOLI hmoment swissprot:PTHP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTHP_ECOLI iep swissprot:PTHP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTHP_ECOLI inforesidue swissprot:PTHP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTHP_ECOLI octanol swissprot:PTHP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTHP_ECOLI pepcoil swissprot:PTHP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTHP_ECOLI pepdigest swissprot:PTHP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTHP_ECOLI pepinfo swissprot:PTHP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTHP_ECOLI pepnet swissprot:PTHP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTHP_ECOLI pepstats swissprot:PTHP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTHP_ECOLI pepwheel swissprot:PTHP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTHP_ECOLI pepwindow swissprot:PTHP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTHP_ECOLI sigcleave swissprot:PTHP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTHP_ECOLI ## Database ID URL or Descriptions # AltName ILVA_ECOLI Threonine deaminase # BioGrid 4259586 18 # CATALYTIC ACTIVITY ILVA_ECOLI L-threonine = 2-oxobutanoate + NH(3). # COFACTOR ILVA_ECOLI Name=pyridoxal 5'-phosphate; Xref=ChEBI CHEBI 597326; Evidence={ECO 0000269|PubMed 5321308}; # ENZYME REGULATION Isoleucine allosterically inhibits whereas valine allosterically activates this enzyme. {ECO:0000269|PubMed 13324101}. # EcoGene EG10493 ilvA # FUNCTION ILVA_ECOLI Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. {ECO 0000269|PubMed 13405870}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0004794 L-threonine ammonia-lyase activity; IDA:EcoliWiki. # GO_function GO:0016597 amino acid binding; IDA:EcoliWiki. # GO_function GO:0030170 pyridoxal phosphate binding; IDA:EcoCyc. # GO_process GO:0006566 threonine metabolic process; IDA:UniProtKB. # GO_process GO:0008652 cellular amino acid biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0009082 branched-chain amino acid biosynthetic process; IMP:EcoliWiki. # GO_process GO:0009097 isoleucine biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # INDUCTION Constitutively expressed. {ECO:0000269|PubMed 13405870}. # IntAct P04968 9 # InterPro IPR000634 Ser/Thr_deHydtase_PyrdxlP-BS # InterPro IPR001721 ACT-like_dom # InterPro IPR001926 TrpB-like_PLP-dep # InterPro IPR005787 Thr_deHydtase_biosynth # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00260 Glycine, serine and threonine metabolism # KEGG_Pathway ko00290 Valine, leucine and isoleucine biosynthesis # Organism ILVA_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-isoleucine biosynthesis; 2- oxobutanoate from L-threonine step 1/1. # PATRIC 32123039 VBIEscCol129921_3889 # PDB 1TDJ X-ray; 2.80 A; A=1-514 # PIR B27310 DWECTS # PROSITE PS00165 DEHYDRATASE_SER_THR # PROSITE PS51672 ACT_LIKE; 2 # Pfam PF00291 PALP # Pfam PF00585 Thr_dehydrat_C; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ILVA_ECOLI L-threonine dehydratase biosynthetic IlvA # RefSeq NP_418220 NC_000913.3 # RefSeq WP_000785596 NZ_LN832404.1 # SIMILARITY Belongs to the serine/threonine dehydratase family. {ECO 0000305}. # SIMILARITY Contains 2 ACT-like domains. {ECO:0000255|PROSITE- ProRule PRU01008}. # SUBUNIT Homotetramer. {ECO:0000269|PubMed 9562556}. # SUPFAM SSF53686 SSF53686 # TIGRFAMs TIGR01124 ilvA_2Cterm # UniPathway UPA00047 UER00054 # eggNOG COG1171 LUCA # eggNOG ENOG4105C7B Bacteria BLAST swissprot:ILVA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ILVA_ECOLI BioCyc ECOL316407:JW3745-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3745-MONOMER BioCyc EcoCyc:THREDEHYDSYN-MONOMER http://biocyc.org/getid?id=EcoCyc:THREDEHYDSYN-MONOMER BioCyc MetaCyc:THREDEHYDSYN-MONOMER http://biocyc.org/getid?id=MetaCyc:THREDEHYDSYN-MONOMER COG COG1171 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1171 DIP DIP-10018N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10018N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0378-1119(87)90136-3 http://dx.doi.org/10.1016/0378-1119(87)90136-3 DOI 10.1016/0378-1119(89)90166-2 http://dx.doi.org/10.1016/0378-1119(89)90166-2 DOI 10.1016/S0969-2126(98)00048-3 http://dx.doi.org/10.1016/S0969-2126(98)00048-3 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/15.5.2137 http://dx.doi.org/10.1093/nar/15.5.2137 DOI 10.1126/science.123.3202.848 http://dx.doi.org/10.1126/science.123.3202.848 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.3.1.19 http://www.genome.jp/dbget-bin/www_bget?EC:4.3.1.19 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K03503 http://www.ebi.ac.uk/ena/data/view/K03503 EMBL M10313 http://www.ebi.ac.uk/ena/data/view/M10313 EMBL M11689 http://www.ebi.ac.uk/ena/data/view/M11689 EMBL M25497 http://www.ebi.ac.uk/ena/data/view/M25497 EMBL M32253 http://www.ebi.ac.uk/ena/data/view/M32253 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X04890 http://www.ebi.ac.uk/ena/data/view/X04890 ENZYME 4.3.1.19 http://enzyme.expasy.org/EC/4.3.1.19 EchoBASE EB0488 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0488 EcoGene EG10493 http://www.ecogene.org/geneInfo.php?eg_id=EG10493 EnsemblBacteria AAC77492 http://www.ensemblgenomes.org/id/AAC77492 EnsemblBacteria AAC77492 http://www.ensemblgenomes.org/id/AAC77492 EnsemblBacteria BAE77525 http://www.ensemblgenomes.org/id/BAE77525 EnsemblBacteria BAE77525 http://www.ensemblgenomes.org/id/BAE77525 EnsemblBacteria BAE77525 http://www.ensemblgenomes.org/id/BAE77525 EnsemblBacteria b3772 http://www.ensemblgenomes.org/id/b3772 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004794 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004794 GO_function GO:0016597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016597 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_process GO:0006566 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006566 GO_process GO:0008652 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008652 GO_process GO:0009082 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009082 GO_process GO:0009097 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009097 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 948287 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948287 HOGENOM HOG000046975 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000046975&db=HOGENOM6 InParanoid P04968 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P04968 IntAct P04968 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P04968* IntEnz 4.3.1.19 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.3.1.19 InterPro IPR000634 http://www.ebi.ac.uk/interpro/entry/IPR000634 InterPro IPR001721 http://www.ebi.ac.uk/interpro/entry/IPR001721 InterPro IPR001926 http://www.ebi.ac.uk/interpro/entry/IPR001926 InterPro IPR005787 http://www.ebi.ac.uk/interpro/entry/IPR005787 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3745 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3745 KEGG_Gene eco:b3772 http://www.genome.jp/dbget-bin/www_bget?eco:b3772 KEGG_Orthology KO:K01754 http://www.genome.jp/dbget-bin/www_bget?KO:K01754 KEGG_Pathway ko00260 http://www.genome.jp/kegg-bin/show_pathway?ko00260 KEGG_Pathway ko00290 http://www.genome.jp/kegg-bin/show_pathway?ko00290 KEGG_Reaction rn:R00220 http://www.genome.jp/dbget-bin/www_bget?rn:R00220 KEGG_Reaction rn:R00996 http://www.genome.jp/dbget-bin/www_bget?rn:R00996 MINT MINT-1305200 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1305200 OMA KENARVF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KENARVF PDB 1TDJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1TDJ PDBsum 1TDJ http://www.ebi.ac.uk/pdbsum/1TDJ PROSITE PS00165 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00165 PROSITE PS51672 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51672 PSORT swissprot:ILVA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ILVA_ECOLI PSORT-B swissprot:ILVA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ILVA_ECOLI PSORT2 swissprot:ILVA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ILVA_ECOLI Pfam PF00291 http://pfam.xfam.org/family/PF00291 Pfam PF00585 http://pfam.xfam.org/family/PF00585 Phobius swissprot:ILVA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ILVA_ECOLI PhylomeDB P04968 http://phylomedb.org/?seqid=P04968 ProteinModelPortal P04968 http://www.proteinmodelportal.org/query/uniprot/P04968 PubMed 13324101 http://www.ncbi.nlm.nih.gov/pubmed/13324101 PubMed 13405870 http://www.ncbi.nlm.nih.gov/pubmed/13405870 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2473940 http://www.ncbi.nlm.nih.gov/pubmed/2473940 PubMed 3003115 http://www.ncbi.nlm.nih.gov/pubmed/3003115 PubMed 3315862 http://www.ncbi.nlm.nih.gov/pubmed/3315862 PubMed 3550695 http://www.ncbi.nlm.nih.gov/pubmed/3550695 PubMed 5321308 http://www.ncbi.nlm.nih.gov/pubmed/5321308 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9562556 http://www.ncbi.nlm.nih.gov/pubmed/9562556 RefSeq NP_418220 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418220 RefSeq WP_000785596 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000785596 SMR P04968 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P04968 STRING 511145.b3772 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3772&targetmode=cogs STRING COG1171 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1171&targetmode=cogs SUPFAM SSF53686 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53686 TIGRFAMs TIGR01124 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01124 UniProtKB ILVA_ECOLI http://www.uniprot.org/uniprot/ILVA_ECOLI UniProtKB-AC P04968 http://www.uniprot.org/uniprot/P04968 charge swissprot:ILVA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ILVA_ECOLI eggNOG COG1171 http://eggnogapi.embl.de/nog_data/html/tree/COG1171 eggNOG ENOG4105C7B http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C7B epestfind swissprot:ILVA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ILVA_ECOLI garnier swissprot:ILVA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ILVA_ECOLI helixturnhelix swissprot:ILVA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ILVA_ECOLI hmoment swissprot:ILVA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ILVA_ECOLI iep swissprot:ILVA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ILVA_ECOLI inforesidue swissprot:ILVA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ILVA_ECOLI octanol swissprot:ILVA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ILVA_ECOLI pepcoil swissprot:ILVA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ILVA_ECOLI pepdigest swissprot:ILVA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ILVA_ECOLI pepinfo swissprot:ILVA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ILVA_ECOLI pepnet swissprot:ILVA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ILVA_ECOLI pepstats swissprot:ILVA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ILVA_ECOLI pepwheel swissprot:ILVA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ILVA_ECOLI pepwindow swissprot:ILVA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ILVA_ECOLI sigcleave swissprot:ILVA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ILVA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262029 299 # EcoGene EG12478 mscM # FUNCTION MSCM_ECOLI Mechanosensitive channel that protects cells against hypoosmotic stress when highly overexpressed. Gates spontaneously in response to increased membrane tension. {ECO 0000269|PubMed 22874652}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006811 ion transport; IEA:UniProtKB-KW. # GO_process GO:0055085 transmembrane transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # IntAct P39285 3 # InterPro IPR006685 MscS_channel # InterPro IPR006686 MscS_channel_CS # InterPro IPR010920 LSM_dom # InterPro IPR011014 MscS_channel_TM-2 # InterPro IPR011066 MscC_channel_C # InterPro IPR024393 MscS_porin # InterPro IPR025692 MscS_IM_dom1 # KEGG_Brite ko02000 Transporters # Organism MSCM_ECOLI Escherichia coli (strain K12) # PATRIC 32123891 VBIEscCol129921_4293 # PIR E65226 E65226 # PROSITE PS01246 UPF0003 # Pfam PF00924 MS_channel # Pfam PF12794 MscS_TM # Pfam PF12795 MscS_porin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MSCM_ECOLI Miniconductance mechanosensitive channel MscM # RefSeq NP_418583 NC_000913.3 # RefSeq WP_001236847 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA83897.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the MscS (TC 1.A.23) family. {ECO 0000305}. # SUBCELLULAR LOCATION MSCM_ECOLI Cell inner membrane {ECO 0000269|PubMed 22874652}; Multi-pass membrane protein {ECO 0000269|PubMed 22874652}. # SUBUNIT Homoheptamer. {ECO:0000269|PubMed 22874652}. # SUPFAM SSF50182 SSF50182 # SUPFAM SSF82689 SSF82689 # SUPFAM SSF82861 SSF82861 # TCDB 1.A.23.1 the small conductance mechanosensitive ion channel (mscs) family # eggNOG COG3264 LUCA # eggNOG ENOG4105EGS Bacteria BLAST swissprot:MSCM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MSCM_ECOLI BioCyc ECOL316407:JW4120-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4120-MONOMER BioCyc EcoCyc:G7840-MONOMER http://biocyc.org/getid?id=EcoCyc:G7840-MONOMER COG COG3264 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3264 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.4161/chan.20998 http://dx.doi.org/10.4161/chan.20998 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J03916 http://www.ebi.ac.uk/ena/data/view/J03916 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2371 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2371 EcoGene EG12478 http://www.ecogene.org/geneInfo.php?eg_id=EG12478 EnsemblBacteria AAC77119 http://www.ensemblgenomes.org/id/AAC77119 EnsemblBacteria AAC77119 http://www.ensemblgenomes.org/id/AAC77119 EnsemblBacteria BAE78163 http://www.ensemblgenomes.org/id/BAE78163 EnsemblBacteria BAE78163 http://www.ensemblgenomes.org/id/BAE78163 EnsemblBacteria BAE78163 http://www.ensemblgenomes.org/id/BAE78163 EnsemblBacteria b4159 http://www.ensemblgenomes.org/id/b4159 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006811 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 948676 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948676 HOGENOM HOG000281473 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000281473&db=HOGENOM6 IntAct P39285 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39285* InterPro IPR006685 http://www.ebi.ac.uk/interpro/entry/IPR006685 InterPro IPR006686 http://www.ebi.ac.uk/interpro/entry/IPR006686 InterPro IPR010920 http://www.ebi.ac.uk/interpro/entry/IPR010920 InterPro IPR011014 http://www.ebi.ac.uk/interpro/entry/IPR011014 InterPro IPR011066 http://www.ebi.ac.uk/interpro/entry/IPR011066 InterPro IPR024393 http://www.ebi.ac.uk/interpro/entry/IPR024393 InterPro IPR025692 http://www.ebi.ac.uk/interpro/entry/IPR025692 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW4120 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4120 KEGG_Gene eco:b4159 http://www.genome.jp/dbget-bin/www_bget?eco:b4159 KEGG_Orthology KO:K05802 http://www.genome.jp/dbget-bin/www_bget?KO:K05802 OMA ARAMRYY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ARAMRYY PROSITE PS01246 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01246 PSORT swissprot:MSCM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MSCM_ECOLI PSORT-B swissprot:MSCM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MSCM_ECOLI PSORT2 swissprot:MSCM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MSCM_ECOLI Pfam PF00924 http://pfam.xfam.org/family/PF00924 Pfam PF12794 http://pfam.xfam.org/family/PF12794 Pfam PF12795 http://pfam.xfam.org/family/PF12795 Phobius swissprot:MSCM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MSCM_ECOLI PhylomeDB P39285 http://phylomedb.org/?seqid=P39285 ProteinModelPortal P39285 http://www.proteinmodelportal.org/query/uniprot/P39285 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22874652 http://www.ncbi.nlm.nih.gov/pubmed/22874652 PubMed 3042771 http://www.ncbi.nlm.nih.gov/pubmed/3042771 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418583 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418583 RefSeq WP_001236847 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001236847 SMR P39285 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39285 STRING 511145.b4159 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4159&targetmode=cogs STRING COG3264 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3264&targetmode=cogs SUPFAM SSF50182 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50182 SUPFAM SSF82689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF82689 SUPFAM SSF82861 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF82861 TCDB 1.A.23.1 http://www.tcdb.org/search/result.php?tc=1.A.23.1 UniProtKB MSCM_ECOLI http://www.uniprot.org/uniprot/MSCM_ECOLI UniProtKB-AC P39285 http://www.uniprot.org/uniprot/P39285 charge swissprot:MSCM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MSCM_ECOLI eggNOG COG3264 http://eggnogapi.embl.de/nog_data/html/tree/COG3264 eggNOG ENOG4105EGS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EGS epestfind swissprot:MSCM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MSCM_ECOLI garnier swissprot:MSCM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MSCM_ECOLI helixturnhelix swissprot:MSCM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MSCM_ECOLI hmoment swissprot:MSCM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MSCM_ECOLI iep swissprot:MSCM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MSCM_ECOLI inforesidue swissprot:MSCM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MSCM_ECOLI octanol swissprot:MSCM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MSCM_ECOLI pepcoil swissprot:MSCM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MSCM_ECOLI pepdigest swissprot:MSCM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MSCM_ECOLI pepinfo swissprot:MSCM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MSCM_ECOLI pepnet swissprot:MSCM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MSCM_ECOLI pepstats swissprot:MSCM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MSCM_ECOLI pepwheel swissprot:MSCM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MSCM_ECOLI pepwindow swissprot:MSCM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MSCM_ECOLI sigcleave swissprot:MSCM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MSCM_ECOLI ## Database ID URL or Descriptions # BioGrid 4261089 194 # EcoGene EG13302 yaiS # GO_function GO:0016787 hydrolase activity; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # Gene3D 3.40.50.10320 -; 1. # InterPro IPR003737 GlcNAc_PI_deacetylase-related # InterPro IPR024078 LmbE-like_dom # Organism YAIS_ECOLI Escherichia coli (strain K12) # PANTHER PTHR12993 PTHR12993 # PATRIC 32115867 VBIEscCol129921_0375 # PIR D64764 D64764 # Pfam PF02585 PIG-L # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAIS_ECOLI Uncharacterized deacetylase YaiS # RefSeq NP_414898 NC_000913.3 # RefSeq WP_000362028 NZ_LN832404.1 # SIMILARITY Belongs to the PIGL family. {ECO 0000305}. # SUPFAM SSF102588 SSF102588 # eggNOG COG2120 LUCA # eggNOG ENOG4107W19 Bacteria BLAST swissprot:YAIS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAIS_ECOLI BioCyc ECOL316407:JW0356-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0356-MONOMER BioCyc EcoCyc:G6216-MONOMER http://biocyc.org/getid?id=EcoCyc:G6216-MONOMER DIP DIP-11278N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11278N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D85613 http://www.ebi.ac.uk/ena/data/view/D85613 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 ENZYME 3.-.-.- http://enzyme.expasy.org/EC/3.-.-.- EchoBASE EB3087 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3087 EcoGene EG13302 http://www.ecogene.org/geneInfo.php?eg_id=EG13302 EnsemblBacteria AAC73467 http://www.ensemblgenomes.org/id/AAC73467 EnsemblBacteria AAC73467 http://www.ensemblgenomes.org/id/AAC73467 EnsemblBacteria BAE76145 http://www.ensemblgenomes.org/id/BAE76145 EnsemblBacteria BAE76145 http://www.ensemblgenomes.org/id/BAE76145 EnsemblBacteria BAE76145 http://www.ensemblgenomes.org/id/BAE76145 EnsemblBacteria b0364 http://www.ensemblgenomes.org/id/b0364 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016787 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016787 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 Gene3D 3.40.50.10320 http://www.cathdb.info/version/latest/superfamily/3.40.50.10320 GeneID 946967 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946967 HOGENOM HOG000241174 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000241174&db=HOGENOM6 InParanoid P71311 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P71311 IntEnz 3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3 InterPro IPR003737 http://www.ebi.ac.uk/interpro/entry/IPR003737 InterPro IPR024078 http://www.ebi.ac.uk/interpro/entry/IPR024078 KEGG_Gene ecj:JW0356 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0356 KEGG_Gene eco:b0364 http://www.genome.jp/dbget-bin/www_bget?eco:b0364 OMA INIDHTV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=INIDHTV PANTHER PTHR12993 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12993 PSORT swissprot:YAIS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAIS_ECOLI PSORT-B swissprot:YAIS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAIS_ECOLI PSORT2 swissprot:YAIS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAIS_ECOLI Pfam PF02585 http://pfam.xfam.org/family/PF02585 Phobius swissprot:YAIS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAIS_ECOLI PhylomeDB P71311 http://phylomedb.org/?seqid=P71311 ProteinModelPortal P71311 http://www.proteinmodelportal.org/query/uniprot/P71311 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8808933 http://www.ncbi.nlm.nih.gov/pubmed/8808933 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414898 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414898 RefSeq WP_000362028 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000362028 SMR P71311 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P71311 STRING 511145.b0364 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0364&targetmode=cogs SUPFAM SSF102588 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF102588 UniProtKB YAIS_ECOLI http://www.uniprot.org/uniprot/YAIS_ECOLI UniProtKB-AC P71311 http://www.uniprot.org/uniprot/P71311 charge swissprot:YAIS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAIS_ECOLI eggNOG COG2120 http://eggnogapi.embl.de/nog_data/html/tree/COG2120 eggNOG ENOG4107W19 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107W19 epestfind swissprot:YAIS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAIS_ECOLI garnier swissprot:YAIS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAIS_ECOLI helixturnhelix swissprot:YAIS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAIS_ECOLI hmoment swissprot:YAIS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAIS_ECOLI iep swissprot:YAIS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAIS_ECOLI inforesidue swissprot:YAIS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAIS_ECOLI octanol swissprot:YAIS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAIS_ECOLI pepcoil swissprot:YAIS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAIS_ECOLI pepdigest swissprot:YAIS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAIS_ECOLI pepinfo swissprot:YAIS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAIS_ECOLI pepnet swissprot:YAIS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAIS_ECOLI pepstats swissprot:YAIS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAIS_ECOLI pepwheel swissprot:YAIS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAIS_ECOLI pepwindow swissprot:YAIS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAIS_ECOLI sigcleave swissprot:YAIS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAIS_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=25 uM for c-di-GMP; pH dependence Optimum pH is 9.35.; # BioGrid 4262803 8 # CDD cd01948 EAL # CDD cd06170 LuxR_C_like # COFACTOR YAHA_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 15995192}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 15995192}; # EcoGene EG11236 yahA # FUNCTION YAHA_ECOLI Hydrolyzes c-di-GMP (cyclic bis(3'-5') dimeric GMP) to 5'-pGpG, known as PDE-A activity. PDE-B activity, that is hydrolysis of 5'-pGpG to GMP, proceeds only very slowly. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0071111 cyclic-guanylate-specific phosphodiesterase activity; IDA:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # Gene3D 1.10.10.10 -; 1. # Gene3D 3.20.20.450 -; 1. # IntAct P21514 3 # InterPro IPR000792 Tscrpt_reg_LuxR_C # InterPro IPR001633 EAL_dom # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR016032 Sig_transdc_resp-reg_C-effctor # KEGG_Brite ko01000 Enzymes # MISCELLANEOUS YAHA_ECOLI An overexpressed EAL domain (residues 77-362) has similar KM, Vmax, pH and metal dependence and subunit composition as the full-length protein. # Organism YAHA_ECOLI Escherichia coli (strain K12) # PATRIC 32115759 VBIEscCol129921_0322 # PDB 4KIE X-ray; 1.70 A; A=96-362 # PDB 4LJ3 X-ray; 1.70 A; A/B=101-362 # PDB 4LYK X-ray; 2.40 A; A/B/C/D=101-362 # PIR C64758 C64758 # PROSITE PS50043 HTH_LUXR_2 # PROSITE PS50883 EAL # Pfam PF00196 GerE # Pfam PF00563 EAL # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAHA_ECOLI Cyclic di-GMP phosphodiesterase YahA # RefSeq NP_414849 NC_000913.3 # RefSeq WP_001301264 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18041.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Contains 1 EAL domain. {ECO:0000255|PROSITE- ProRule PRU00074}. # SIMILARITY Contains 1 HTH luxR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00411}. # SMART SM00052 EAL # SMART SM00421 HTH_LUXR # SUBUNIT Monomer. {ECO:0000269|PubMed 15995192}. # SUPFAM SSF141868 SSF141868 # SUPFAM SSF46894 SSF46894 # eggNOG COG2200 LUCA # eggNOG COG2771 LUCA # eggNOG ENOG4105BZU Bacteria BLAST swissprot:YAHA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAHA_ECOLI BioCyc ECOL316407:JW0307-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0307-MONOMER BioCyc EcoCyc:EG11236-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11236-MONOMER BioCyc MetaCyc:EG11236-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11236-MONOMER COG COG2200 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2200 COG COG2771 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2771 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1991.tb01877.x http://dx.doi.org/10.1111/j.1365-2958.1991.tb01877.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.187.14.4774-4781.2005 http://dx.doi.org/10.1128/JB.187.14.4774-4781.2005 EC_number EC:3.1.4.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.4.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EMBL X52905 http://www.ebi.ac.uk/ena/data/view/X52905 ENZYME 3.1.4.- http://enzyme.expasy.org/EC/3.1.4.- EchoBASE EB1218 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1218 EcoGene EG11236 http://www.ecogene.org/geneInfo.php?eg_id=EG11236 EnsemblBacteria AAC73418 http://www.ensemblgenomes.org/id/AAC73418 EnsemblBacteria AAC73418 http://www.ensemblgenomes.org/id/AAC73418 EnsemblBacteria BAE76098 http://www.ensemblgenomes.org/id/BAE76098 EnsemblBacteria BAE76098 http://www.ensemblgenomes.org/id/BAE76098 EnsemblBacteria BAE76098 http://www.ensemblgenomes.org/id/BAE76098 EnsemblBacteria b0315 http://www.ensemblgenomes.org/id/b0315 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0071111 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071111 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 3.20.20.450 http://www.cathdb.info/version/latest/superfamily/3.20.20.450 GeneID 947459 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947459 HOGENOM HOG000117345 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117345&db=HOGENOM6 InParanoid P21514 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P21514 IntAct P21514 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P21514* IntEnz 3.1.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.4 InterPro IPR000792 http://www.ebi.ac.uk/interpro/entry/IPR000792 InterPro IPR001633 http://www.ebi.ac.uk/interpro/entry/IPR001633 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR016032 http://www.ebi.ac.uk/interpro/entry/IPR016032 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0307 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0307 KEGG_Gene eco:b0315 http://www.genome.jp/dbget-bin/www_bget?eco:b0315 KEGG_Orthology KO:K13244 http://www.genome.jp/dbget-bin/www_bget?KO:K13244 KEGG_Reaction rn:R08991 http://www.genome.jp/dbget-bin/www_bget?rn:R08991 OMA TTELMNC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TTELMNC PDB 4KIE http://www.ebi.ac.uk/pdbe-srv/view/entry/4KIE PDB 4LJ3 http://www.ebi.ac.uk/pdbe-srv/view/entry/4LJ3 PDB 4LYK http://www.ebi.ac.uk/pdbe-srv/view/entry/4LYK PDBsum 4KIE http://www.ebi.ac.uk/pdbsum/4KIE PDBsum 4LJ3 http://www.ebi.ac.uk/pdbsum/4LJ3 PDBsum 4LYK http://www.ebi.ac.uk/pdbsum/4LYK PROSITE PS50043 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50043 PROSITE PS50883 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50883 PSORT swissprot:YAHA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAHA_ECOLI PSORT-B swissprot:YAHA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAHA_ECOLI PSORT2 swissprot:YAHA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAHA_ECOLI Pfam PF00196 http://pfam.xfam.org/family/PF00196 Pfam PF00563 http://pfam.xfam.org/family/PF00563 Phobius swissprot:YAHA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAHA_ECOLI PhylomeDB P21514 http://phylomedb.org/?seqid=P21514 ProteinModelPortal P21514 http://www.proteinmodelportal.org/query/uniprot/P21514 PubMed 15995192 http://www.ncbi.nlm.nih.gov/pubmed/15995192 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1956285 http://www.ncbi.nlm.nih.gov/pubmed/1956285 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414849 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414849 RefSeq WP_001301264 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001301264 SMART SM00052 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00052 SMART SM00421 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00421 SMR P21514 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P21514 STRING 511145.b0315 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0315&targetmode=cogs STRING COG2200 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2200&targetmode=cogs STRING COG2771 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2771&targetmode=cogs SUPFAM SSF141868 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF141868 SUPFAM SSF46894 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46894 UniProtKB YAHA_ECOLI http://www.uniprot.org/uniprot/YAHA_ECOLI UniProtKB-AC P21514 http://www.uniprot.org/uniprot/P21514 charge swissprot:YAHA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAHA_ECOLI eggNOG COG2200 http://eggnogapi.embl.de/nog_data/html/tree/COG2200 eggNOG COG2771 http://eggnogapi.embl.de/nog_data/html/tree/COG2771 eggNOG ENOG4105BZU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZU epestfind swissprot:YAHA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAHA_ECOLI garnier swissprot:YAHA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAHA_ECOLI helixturnhelix swissprot:YAHA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAHA_ECOLI hmoment swissprot:YAHA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAHA_ECOLI iep swissprot:YAHA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAHA_ECOLI inforesidue swissprot:YAHA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAHA_ECOLI octanol swissprot:YAHA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAHA_ECOLI pepcoil swissprot:YAHA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAHA_ECOLI pepdigest swissprot:YAHA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAHA_ECOLI pepinfo swissprot:YAHA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAHA_ECOLI pepnet swissprot:YAHA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAHA_ECOLI pepstats swissprot:YAHA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAHA_ECOLI pepwheel swissprot:YAHA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAHA_ECOLI pepwindow swissprot:YAHA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAHA_ECOLI sigcleave swissprot:YAHA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAHA_ECOLI ## Database ID URL or Descriptions # AltName GSPG_ECOLI Protein transport protein HofG # AltName GSPG_ECOLI Putative general secretion pathway protein G # BioGrid 4262167 250 # EcoGene EG12886 gspG # FUNCTION GSPG_ECOLI Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. {ECO 0000305}. # GO_component GO:0015627 type II protein secretion system complex; IEA:InterPro. # GO_function GO:0008565 protein transporter activity; IEA:InterPro. # GO_process GO:0015628 protein secretion by the type II secretion system; IBA:GO_Central. # GOslim_component GO:0043234 protein complex # GOslim_function GO:0008565 protein transporter activity # GOslim_process GO:0055085 transmembrane transport # INDUCTION Silenced by the DNA-binding protein H-NS under standard growth conditions. {ECO:0000269|PubMed 11118204}. # InterPro IPR000983 Bac_GSPG_pilin # InterPro IPR010054 Type2_sec_GspG # InterPro IPR012902 N_methyl_site # InterPro IPR013545 T2SS_protein-G # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02044 M00331 Type II general secretion system # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko03070 Bacterial secretion system # MISCELLANEOUS GSPG_ECOLI Part of a cryptic operon that encodes proteins involved in type II secretion machinery in other organisms, but is not expressed in strain K12. # Organism GSPG_ECOLI Escherichia coli (strain K12) # PATRIC 32122088 VBIEscCol129921_3421 # PIR B56150 B56150 # PRINTS PR00813 BCTERIALGSPG # PROSITE PS00409 PROKAR_NTER_METHYL # Pfam PF07963 N_methyl # Pfam PF08334 T2SSG # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GSPG_ECOLI Putative type II secretion system protein G # RefSeq NP_417787 NC_000913.3 # RefSeq WP_001202874 NZ_LN832404.1 # SIMILARITY Belongs to the GSP G family. {ECO 0000305}. # TIGRFAMs TIGR01710 typeII_sec_gspG # TIGRFAMs TIGR02532 IV_pilin_GFxxxE # eggNOG COG2165 LUCA # eggNOG ENOG4108VAU Bacteria BLAST swissprot:GSPG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GSPG_ECOLI BioCyc ECOL316407:JW3290-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3290-MONOMER BioCyc EcoCyc:G7706-MONOMER http://biocyc.org/getid?id=EcoCyc:G7706-MONOMER BioCyc MetaCyc:G7706-MONOMER http://biocyc.org/getid?id=MetaCyc:G7706-MONOMER COG COG2165 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2165 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/emboj/19.24.6697 http://dx.doi.org/10.1093/emboj/19.24.6697 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL U20786 http://www.ebi.ac.uk/ena/data/view/U20786 EchoBASE EB2723 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2723 EcoGene EG12886 http://www.ecogene.org/geneInfo.php?eg_id=EG12886 EnsemblBacteria AAC76353 http://www.ensemblgenomes.org/id/AAC76353 EnsemblBacteria AAC76353 http://www.ensemblgenomes.org/id/AAC76353 EnsemblBacteria BAE77963 http://www.ensemblgenomes.org/id/BAE77963 EnsemblBacteria BAE77963 http://www.ensemblgenomes.org/id/BAE77963 EnsemblBacteria BAE77963 http://www.ensemblgenomes.org/id/BAE77963 EnsemblBacteria b3328 http://www.ensemblgenomes.org/id/b3328 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0015627 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015627 GO_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GO_process GO:0015628 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015628 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 947827 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947827 HOGENOM HOG000008196 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000008196&db=HOGENOM6 InParanoid P41442 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P41442 InterPro IPR000983 http://www.ebi.ac.uk/interpro/entry/IPR000983 InterPro IPR010054 http://www.ebi.ac.uk/interpro/entry/IPR010054 InterPro IPR012902 http://www.ebi.ac.uk/interpro/entry/IPR012902 InterPro IPR013545 http://www.ebi.ac.uk/interpro/entry/IPR013545 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW3290 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3290 KEGG_Gene eco:b3328 http://www.genome.jp/dbget-bin/www_bget?eco:b3328 KEGG_Orthology KO:K02456 http://www.genome.jp/dbget-bin/www_bget?KO:K02456 KEGG_Pathway ko03070 http://www.genome.jp/kegg-bin/show_pathway?ko03070 OMA IGNWNVG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IGNWNVG PRINTS PR00813 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00813 PROSITE PS00409 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00409 PSORT swissprot:GSPG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GSPG_ECOLI PSORT-B swissprot:GSPG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GSPG_ECOLI PSORT2 swissprot:GSPG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GSPG_ECOLI Pfam PF07963 http://pfam.xfam.org/family/PF07963 Pfam PF08334 http://pfam.xfam.org/family/PF08334 Phobius swissprot:GSPG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GSPG_ECOLI PhylomeDB P41442 http://phylomedb.org/?seqid=P41442 ProteinModelPortal P41442 http://www.proteinmodelportal.org/query/uniprot/P41442 PubMed 11118204 http://www.ncbi.nlm.nih.gov/pubmed/11118204 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7896718 http://www.ncbi.nlm.nih.gov/pubmed/7896718 PubMed 8655552 http://www.ncbi.nlm.nih.gov/pubmed/8655552 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417787 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417787 RefSeq WP_001202874 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001202874 SMR P41442 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P41442 STRING 511145.b3328 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3328&targetmode=cogs STRING COG2165 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2165&targetmode=cogs TIGRFAMs TIGR01710 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01710 TIGRFAMs TIGR02532 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02532 UniProtKB GSPG_ECOLI http://www.uniprot.org/uniprot/GSPG_ECOLI UniProtKB-AC P41442 http://www.uniprot.org/uniprot/P41442 charge swissprot:GSPG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GSPG_ECOLI eggNOG COG2165 http://eggnogapi.embl.de/nog_data/html/tree/COG2165 eggNOG ENOG4108VAU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108VAU epestfind swissprot:GSPG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GSPG_ECOLI garnier swissprot:GSPG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GSPG_ECOLI helixturnhelix swissprot:GSPG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GSPG_ECOLI hmoment swissprot:GSPG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GSPG_ECOLI iep swissprot:GSPG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GSPG_ECOLI inforesidue swissprot:GSPG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GSPG_ECOLI octanol swissprot:GSPG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GSPG_ECOLI pepcoil swissprot:GSPG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GSPG_ECOLI pepdigest swissprot:GSPG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GSPG_ECOLI pepinfo swissprot:GSPG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GSPG_ECOLI pepnet swissprot:GSPG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GSPG_ECOLI pepstats swissprot:GSPG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GSPG_ECOLI pepwheel swissprot:GSPG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GSPG_ECOLI pepwindow swissprot:GSPG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GSPG_ECOLI sigcleave swissprot:GSPG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GSPG_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES POTA_ECOLI Kinetic parameters KM=385 uM for ATP {ECO 0000269|PubMed 11976340, ECO 0000269|PubMed 7592703}; Vmax=400 nmol/min/mg enzyme {ECO 0000269|PubMed 11976340, ECO 0000269|PubMed 7592703}; # BioGrid 4261674 3 # CATALYTIC ACTIVITY ATP + H(2)O + polyamine(Out) = ADP + phosphate + polyamine(In). {ECO:0000255|HAMAP-Rule MF_01726}. # ENZYME REGULATION POTA_ECOLI Strongly inhibited by carbonyl cyanide m- chlorophenylhydrazone (CCCP), and by spermidine via its interaction with the C-terminus. Also inhibited by N- ethylmaleimide and p-chloromercuribenzoic acid. Partially inhibited by KCN. {ECO 0000269|PubMed 11976340, ECO 0000269|PubMed 2249996, ECO 0000269|PubMed 7592703, ECO 0000269|PubMed 8366082}. # EcoGene EG10749 potA # FUNCTION POTA_ECOLI Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system. {ECO 0000255|HAMAP-Rule MF_01726, ECO 0000269|PubMed 1939142, ECO 0000269|PubMed 2249996, ECO 0000269|PubMed 8366082}. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IEA:UniProtKB-HAMAP. # GO_function GO:0005524 ATP binding; IDA:EcoCyc. # GO_function GO:0015417 polyamine-transporting ATPase activity; IMP:EcoCyc. # GO_function GO:0015594 putrescine-importing ATPase activity; IEA:InterPro. # GO_function GO:0015595 spermidine-importing ATPase activity; IEA:InterPro. # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.300 -; 1. # INDUCTION Transcription is inhibited by PotD precursor, probably only when excess amounts of PotD are produced. {ECO:0000269|PubMed 9890949}. # IntAct P69874 2 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR005893 Sp_pt_ABC_ATP-bd # InterPro IPR008995 Mo/tungstate-bd_C_term_dom # InterPro IPR013611 Transp-assoc_OB_typ2 # InterPro IPR017871 ABC_transporter_CS # InterPro IPR017879 ABC_Sperm/Put_ATP-bd_PotA # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00299 Spermidine/putrescine transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism POTA_ECOLI Escherichia coli (strain K12) # PATRIC 32117499 VBIEscCol129921_1172 # PIR A40840 A40840 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # PROSITE PS51305 POTA # PTM POTA_ECOLI The N-terminus is blocked. {ECO 0000305}. # Pfam PF00005 ABC_tran # Pfam PF08402 TOBE_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Spermidine/putrescine import ATP-binding protein PotA {ECO:0000255|HAMAP-Rule MF_01726} # RefSeq NP_415644 NC_000913.3 # RefSeq WP_000531594 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family. {ECO:0000255|HAMAP-Rule MF_01726}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|HAMAP- Rule MF_01726}. # SMART SM00382 AAA # SUBCELLULAR LOCATION POTA_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01726, ECO 0000269|PubMed 1939142, ECO 0000269|PubMed 7592703}; Peripheral membrane protein {ECO 0000255|HAMAP-Rule MF_01726, ECO 0000269|PubMed 1939142, ECO 0000269|PubMed 7592703}. # SUBUNIT The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute- binding protein (PotD). {ECO:0000255|HAMAP-Rule MF_01726}. # SUPFAM SSF50331 SSF50331 # SUPFAM SSF52540 SSF52540 # TCDB 3.A.1.11 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR01187 potA # eggNOG COG3842 LUCA # eggNOG ENOG4105C53 Bacteria BLAST swissprot:POTA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:POTA_ECOLI BioCyc ECOL316407:JW1112-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1112-MONOMER BioCyc EcoCyc:POTA-MONOMER http://biocyc.org/getid?id=EcoCyc:POTA-MONOMER BioCyc MetaCyc:POTA-MONOMER http://biocyc.org/getid?id=MetaCyc:POTA-MONOMER COG COG3842 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3842 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.270.43.25377 http://dx.doi.org/10.1074/jbc.270.43.25377 DOI 10.1074/jbc.274.4.1942 http://dx.doi.org/10.1074/jbc.274.4.1942 DOI 10.1074/jbc.M202849200 http://dx.doi.org/10.1074/jbc.M202849200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.3.31 {ECO:0000255|HAMAP-Rule:MF_01726} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.31 {ECO:0000255|HAMAP-Rule:MF_01726} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M64519 http://www.ebi.ac.uk/ena/data/view/M64519 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.6.3.31 {ECO:0000255|HAMAP-Rule:MF_01726} http://enzyme.expasy.org/EC/3.6.3.31 {ECO:0000255|HAMAP-Rule:MF_01726} EchoBASE EB0742 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0742 EcoGene EG10749 http://www.ecogene.org/geneInfo.php?eg_id=EG10749 EnsemblBacteria AAC74210 http://www.ensemblgenomes.org/id/AAC74210 EnsemblBacteria AAC74210 http://www.ensemblgenomes.org/id/AAC74210 EnsemblBacteria BAA35946 http://www.ensemblgenomes.org/id/BAA35946 EnsemblBacteria BAA35946 http://www.ensemblgenomes.org/id/BAA35946 EnsemblBacteria BAA35946 http://www.ensemblgenomes.org/id/BAA35946 EnsemblBacteria b1126 http://www.ensemblgenomes.org/id/b1126 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0015417 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015417 GO_function GO:0015594 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015594 GO_function GO:0015595 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015595 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 946323 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946323 InParanoid P69874 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P69874 IntAct P69874 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69874* IntEnz 3.6.3.31 {ECO:0000255|HAMAP-Rule:MF_01726} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.31 {ECO:0000255|HAMAP-Rule:MF_01726} InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR005893 http://www.ebi.ac.uk/interpro/entry/IPR005893 InterPro IPR008995 http://www.ebi.ac.uk/interpro/entry/IPR008995 InterPro IPR013611 http://www.ebi.ac.uk/interpro/entry/IPR013611 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR017879 http://www.ebi.ac.uk/interpro/entry/IPR017879 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1112 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1112 KEGG_Gene eco:b1126 http://www.genome.jp/dbget-bin/www_bget?eco:b1126 KEGG_Orthology KO:K11072 http://www.genome.jp/dbget-bin/www_bget?KO:K11072 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA IGYIRER http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IGYIRER PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PROSITE PS51305 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51305 PSORT swissprot:POTA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:POTA_ECOLI PSORT-B swissprot:POTA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:POTA_ECOLI PSORT2 swissprot:POTA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:POTA_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Pfam PF08402 http://pfam.xfam.org/family/PF08402 Phobius swissprot:POTA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:POTA_ECOLI PhylomeDB P69874 http://phylomedb.org/?seqid=P69874 ProteinModelPortal P69874 http://www.proteinmodelportal.org/query/uniprot/P69874 PubMed 11976340 http://www.ncbi.nlm.nih.gov/pubmed/11976340 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1939142 http://www.ncbi.nlm.nih.gov/pubmed/1939142 PubMed 2249996 http://www.ncbi.nlm.nih.gov/pubmed/2249996 PubMed 7592703 http://www.ncbi.nlm.nih.gov/pubmed/7592703 PubMed 8366082 http://www.ncbi.nlm.nih.gov/pubmed/8366082 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9890949 http://www.ncbi.nlm.nih.gov/pubmed/9890949 RefSeq NP_415644 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415644 RefSeq WP_000531594 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000531594 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P69874 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69874 STRING 511145.b1126 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1126&targetmode=cogs STRING COG3842 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3842&targetmode=cogs SUPFAM SSF50331 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50331 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.11 http://www.tcdb.org/search/result.php?tc=3.A.1.11 TIGRFAMs TIGR01187 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01187 UniProtKB POTA_ECOLI http://www.uniprot.org/uniprot/POTA_ECOLI UniProtKB-AC P69874 http://www.uniprot.org/uniprot/P69874 charge swissprot:POTA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:POTA_ECOLI eggNOG COG3842 http://eggnogapi.embl.de/nog_data/html/tree/COG3842 eggNOG ENOG4105C53 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C53 epestfind swissprot:POTA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:POTA_ECOLI garnier swissprot:POTA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:POTA_ECOLI helixturnhelix swissprot:POTA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:POTA_ECOLI hmoment swissprot:POTA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:POTA_ECOLI iep swissprot:POTA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:POTA_ECOLI inforesidue swissprot:POTA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:POTA_ECOLI octanol swissprot:POTA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:POTA_ECOLI pepcoil swissprot:POTA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:POTA_ECOLI pepdigest swissprot:POTA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:POTA_ECOLI pepinfo swissprot:POTA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:POTA_ECOLI pepnet swissprot:POTA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:POTA_ECOLI pepstats swissprot:POTA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:POTA_ECOLI pepwheel swissprot:POTA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:POTA_ECOLI pepwindow swissprot:POTA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:POTA_ECOLI sigcleave swissprot:POTA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:POTA_ECOLI ## Database ID URL or Descriptions # AltName HIGB_ECOLI Endoribonuclease HigB # AltName HIGB_ECOLI Toxin HigB # BioGrid 4262402 8 # EcoGene EG12725 higB # FUNCTION HIGB_ECOLI Toxic component of a toxin-antitoxin (TA) module. A probable translation-dependent mRNA interferase. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation; this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase. {ECO 0000269|PubMed 19943910}. # GO_function GO:0003723 RNA binding; IEA:UniProtKB-KW. # GO_function GO:0004521 endoribonuclease activity; IDA:EcoCyc. # GO_process GO:0017148 negative regulation of translation; IDA:EcoCyc. # GO_process GO:0043488 regulation of mRNA stability; IDA:EcoCyc. # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0004518 nuclease activity # GOslim_process GO:0008150 biological_process # INDUCTION Induced by amino acid starvation and when translation is blocked. Induction is decreased in the absence of the Lon protease suggesting, by homology to other toxin-antitoxin systems, that Lon may degrade the HigA antitoxin. Transcription is negatively regulated by the cognate locus, probably by HigA. A member of the higB-higA operon. {ECO:0000269|PubMed 19943910}. # IntAct P64578 2 # InterPro IPR018669 Toxin_HigB_put # Organism HIGB_ECOLI Escherichia coli (strain K12) # PATRIC 32121584 VBIEscCol129921_3178 # PIR H65096 H65096 # Pfam PF09907 HigB_toxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HIGB_ECOLI mRNA interferase HigB # RefSeq NP_417554 NC_000913.3 # RefSeq WP_000550189 NZ_LN832404.1 # SIMILARITY Belongs to the HigB mRNA interferase family. {ECO 0000305}. # SUBUNIT Probably forms a complex with the antitoxin HigA which inhibits the mRNA interferase activity. {ECO 0000305}. # eggNOG COG4680 LUCA # eggNOG ENOG4105R48 Bacteria BLAST swissprot:HIGB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HIGB_ECOLI BioCyc ECOL316407:JW3054-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3054-MONOMER BioCyc EcoCyc:G7602-MONOMER http://biocyc.org/getid?id=EcoCyc:G7602-MONOMER BioCyc MetaCyc:G7602-MONOMER http://biocyc.org/getid?id=MetaCyc:G7602-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2009.06969.x http://dx.doi.org/10.1111/j.1365-2958.2009.06969.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 3.1.-.- http://enzyme.expasy.org/EC/3.1.-.- EchoBASE EB2584 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2584 EcoGene EG12725 http://www.ecogene.org/geneInfo.php?eg_id=EG12725 EnsemblBacteria AAC76118 http://www.ensemblgenomes.org/id/AAC76118 EnsemblBacteria AAC76118 http://www.ensemblgenomes.org/id/AAC76118 EnsemblBacteria BAE77133 http://www.ensemblgenomes.org/id/BAE77133 EnsemblBacteria BAE77133 http://www.ensemblgenomes.org/id/BAE77133 EnsemblBacteria BAE77133 http://www.ensemblgenomes.org/id/BAE77133 EnsemblBacteria b3083 http://www.ensemblgenomes.org/id/b3083 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0004521 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004521 GO_process GO:0017148 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017148 GO_process GO:0043488 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043488 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 947591 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947591 HOGENOM HOG000026126 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000026126&db=HOGENOM6 InParanoid P64578 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P64578 IntAct P64578 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P64578* IntEnz 3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1 InterPro IPR018669 http://www.ebi.ac.uk/interpro/entry/IPR018669 KEGG_Gene ecj:JW3054 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3054 KEGG_Gene eco:b3083 http://www.genome.jp/dbget-bin/www_bget?eco:b3083 OMA TIFPSAD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TIFPSAD PSORT swissprot:HIGB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HIGB_ECOLI PSORT-B swissprot:HIGB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HIGB_ECOLI PSORT2 swissprot:HIGB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HIGB_ECOLI Pfam PF09907 http://pfam.xfam.org/family/PF09907 Phobius swissprot:HIGB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HIGB_ECOLI ProteinModelPortal P64578 http://www.proteinmodelportal.org/query/uniprot/P64578 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19943910 http://www.ncbi.nlm.nih.gov/pubmed/19943910 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417554 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417554 RefSeq WP_000550189 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000550189 STRING 511145.b3083 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3083&targetmode=cogs UniProtKB HIGB_ECOLI http://www.uniprot.org/uniprot/HIGB_ECOLI UniProtKB-AC P64578 http://www.uniprot.org/uniprot/P64578 charge swissprot:HIGB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HIGB_ECOLI eggNOG COG4680 http://eggnogapi.embl.de/nog_data/html/tree/COG4680 eggNOG ENOG4105R48 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105R48 epestfind swissprot:HIGB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HIGB_ECOLI garnier swissprot:HIGB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HIGB_ECOLI helixturnhelix swissprot:HIGB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HIGB_ECOLI hmoment swissprot:HIGB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HIGB_ECOLI iep swissprot:HIGB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HIGB_ECOLI inforesidue swissprot:HIGB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HIGB_ECOLI octanol swissprot:HIGB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HIGB_ECOLI pepcoil swissprot:HIGB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HIGB_ECOLI pepdigest swissprot:HIGB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HIGB_ECOLI pepinfo swissprot:HIGB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HIGB_ECOLI pepnet swissprot:HIGB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HIGB_ECOLI pepstats swissprot:HIGB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HIGB_ECOLI pepwheel swissprot:HIGB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HIGB_ECOLI pepwindow swissprot:HIGB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HIGB_ECOLI sigcleave swissprot:HIGB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HIGB_ECOLI ## Database ID URL or Descriptions # EcoGene EG14465 uof # FUNCTION LPFUR_ECOLI Cotranscribed with fur, it is essential for fur translation. The fur ribosomal binding site (RBS) is occluded by the 5'-mRNA secondary structure, which is opened by uof translation. {ECO 0000269|PubMed 17268550}. # GO_process GO:0006417 regulation of translation; IDA:EcoCyc. # GOslim_process GO:0008150 biological_process # INDUCTION By iron depletion. Repressed by the ncRNA ryhB. {ECO:0000269|PubMed 17268550}. # Organism LPFUR_ECOLI Escherichia coli (strain K12) # Proteomes UP000000625 Chromosome # RecName LPFUR_ECOLI Fur leader peptide # RefSeq WP_001406816 NZ_LN832404.1 # RefSeq YP_001491546 NC_000913.3 BLAST swissprot:LPFUR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LPFUR_ECOLI BioCyc EcoCyc:MONOMER0-2801 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2801 DOI 10.1038/sj.emboj.7601553 http://dx.doi.org/10.1038/sj.emboj.7601553 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14465 http://www.ecogene.org/geneInfo.php?eg_id=EG14465 EnsemblBacteria ABV59574 http://www.ensemblgenomes.org/id/ABV59574 EnsemblBacteria ABV59574 http://www.ensemblgenomes.org/id/ABV59574 EnsemblBacteria b4637 http://www.ensemblgenomes.org/id/b4637 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006417 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006417 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 5625562 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5625562 KEGG_Gene eco:b4637 http://www.genome.jp/dbget-bin/www_bget?eco:b4637 PSORT swissprot:LPFUR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LPFUR_ECOLI PSORT-B swissprot:LPFUR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LPFUR_ECOLI PSORT2 swissprot:LPFUR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LPFUR_ECOLI Phobius swissprot:LPFUR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LPFUR_ECOLI PubMed 17268550 http://www.ncbi.nlm.nih.gov/pubmed/17268550 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001406816 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001406816 RefSeq YP_001491546 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001491546 STRING 511145.b4637 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4637&targetmode=cogs UniProtKB LPFUR_ECOLI http://www.uniprot.org/uniprot/LPFUR_ECOLI UniProtKB-AC A8DYP9 http://www.uniprot.org/uniprot/A8DYP9 charge swissprot:LPFUR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LPFUR_ECOLI epestfind swissprot:LPFUR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LPFUR_ECOLI garnier swissprot:LPFUR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LPFUR_ECOLI helixturnhelix swissprot:LPFUR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LPFUR_ECOLI hmoment swissprot:LPFUR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LPFUR_ECOLI iep swissprot:LPFUR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LPFUR_ECOLI inforesidue swissprot:LPFUR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LPFUR_ECOLI octanol swissprot:LPFUR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LPFUR_ECOLI pepcoil swissprot:LPFUR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LPFUR_ECOLI pepdigest swissprot:LPFUR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LPFUR_ECOLI pepinfo swissprot:LPFUR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LPFUR_ECOLI pepnet swissprot:LPFUR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LPFUR_ECOLI pepstats swissprot:LPFUR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LPFUR_ECOLI pepwheel swissprot:LPFUR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LPFUR_ECOLI pepwindow swissprot:LPFUR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LPFUR_ECOLI sigcleave swissprot:LPFUR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LPFUR_ECOLI ## Database ID URL or Descriptions # BioGrid 4260143 13 # EcoGene EG11246 uspE # FUNCTION USPE_ECOLI Required for resistance to DNA-damaging agents. {ECO 0000269|PubMed 11849540}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_process GO:0034644 cellular response to UV; IMP:EcoCyc. # GO_process GO:0044010 single-species biofilm formation; IMP:EcoCyc. # GO_process GO:0070301 cellular response to hydrogen peroxide; IEP:EcoCyc. # GO_process GO:0071973 bacterial-type flagellum-dependent cell motility; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0048870 cell motility # Gene3D 3.40.50.620 -; 2. # INDUCTION During growth inhibition caused by the exhaustion of any of a variety of nutrients (carbon, nitrogen, phosphate, sulfate, required amino acid) or by the presence of a variety of toxic agents. Positively regulated by guanosine 3',5'-bisphosphate (ppGpp) and by a RecA/FtsK-dependent regulatory pathway. {ECO:0000269|PubMed 11849540}. # InterPro IPR006016 UspA # InterPro IPR014729 Rossmann-like_a/b/a_fold # Organism USPE_ECOLI Escherichia coli (strain K12) # PATRIC 32117942 VBIEscCol129921_1391 # PDB 5CB0 X-ray; 3.21 A; A/B=1-316 # PIR H64882 QQECX # Pfam PF00582 Usp; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName USPE_ECOLI Universal stress protein E # RefSeq NP_415849 NC_000913.3 # RefSeq WP_001262123 NZ_LN832404.1 # SIMILARITY Belongs to the universal stress protein A family. {ECO 0000305}. # SUBCELLULAR LOCATION USPE_ECOLI Cytoplasm {ECO 0000250}. # eggNOG COG0589 LUCA # eggNOG ENOG4105Q9Y Bacteria BLAST swissprot:USPE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:USPE_ECOLI BioCyc ECOL316407:JW1327-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1327-MONOMER BioCyc EcoCyc:EG11246-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11246-MONOMER COG COG0589 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0589 DIP DIP-48118N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48118N DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1006/jmbi.1998.1726 http://dx.doi.org/10.1006/jmbi.1998.1726 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2002.02720.x http://dx.doi.org/10.1046/j.1365-2958.2002.02720.x DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/10.19.6119 http://dx.doi.org/10.1093/nar/10.19.6119 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01608 http://www.ebi.ac.uk/ena/data/view/J01608 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1227 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1227 EcoGene EG11246 http://www.ecogene.org/geneInfo.php?eg_id=EG11246 EnsemblBacteria AAC74415 http://www.ensemblgenomes.org/id/AAC74415 EnsemblBacteria AAC74415 http://www.ensemblgenomes.org/id/AAC74415 EnsemblBacteria BAA14926 http://www.ensemblgenomes.org/id/BAA14926 EnsemblBacteria BAA14926 http://www.ensemblgenomes.org/id/BAA14926 EnsemblBacteria BAA14926 http://www.ensemblgenomes.org/id/BAA14926 EnsemblBacteria b1333 http://www.ensemblgenomes.org/id/b1333 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_process GO:0034644 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034644 GO_process GO:0044010 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044010 GO_process GO:0070301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070301 GO_process GO:0071973 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071973 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 GeneID 945904 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945904 HOGENOM HOG000277987 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000277987&db=HOGENOM6 InParanoid P0AAC0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAC0 IntAct P0AAC0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAC0* InterPro IPR006016 http://www.ebi.ac.uk/interpro/entry/IPR006016 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 KEGG_Gene ecj:JW1327 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1327 KEGG_Gene eco:b1333 http://www.genome.jp/dbget-bin/www_bget?eco:b1333 KEGG_Orthology KO:K14055 http://www.genome.jp/dbget-bin/www_bget?KO:K14055 MINT MINT-7290918 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-7290918 OMA MAKYQNM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MAKYQNM PDB 5CB0 http://www.ebi.ac.uk/pdbe-srv/view/entry/5CB0 PDBsum 5CB0 http://www.ebi.ac.uk/pdbsum/5CB0 PSORT swissprot:USPE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:USPE_ECOLI PSORT-B swissprot:USPE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:USPE_ECOLI PSORT2 swissprot:USPE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:USPE_ECOLI Pfam PF00582 http://pfam.xfam.org/family/PF00582 Phobius swissprot:USPE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:USPE_ECOLI PhylomeDB P0AAC0 http://phylomedb.org/?seqid=P0AAC0 ProteinModelPortal P0AAC0 http://www.proteinmodelportal.org/query/uniprot/P0AAC0 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 11849540 http://www.ncbi.nlm.nih.gov/pubmed/11849540 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6292868 http://www.ncbi.nlm.nih.gov/pubmed/6292868 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 RefSeq NP_415849 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415849 RefSeq WP_001262123 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001262123 SMR P0AAC0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAC0 STRING 511145.b1333 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1333&targetmode=cogs STRING COG0589 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0589&targetmode=cogs SWISS-2DPAGE P0AAC0 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AAC0 UniProtKB USPE_ECOLI http://www.uniprot.org/uniprot/USPE_ECOLI UniProtKB-AC P0AAC0 http://www.uniprot.org/uniprot/P0AAC0 charge swissprot:USPE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:USPE_ECOLI eggNOG COG0589 http://eggnogapi.embl.de/nog_data/html/tree/COG0589 eggNOG ENOG4105Q9Y http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105Q9Y epestfind swissprot:USPE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:USPE_ECOLI garnier swissprot:USPE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:USPE_ECOLI helixturnhelix swissprot:USPE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:USPE_ECOLI hmoment swissprot:USPE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:USPE_ECOLI iep swissprot:USPE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:USPE_ECOLI inforesidue swissprot:USPE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:USPE_ECOLI octanol swissprot:USPE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:USPE_ECOLI pepcoil swissprot:USPE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:USPE_ECOLI pepdigest swissprot:USPE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:USPE_ECOLI pepinfo swissprot:USPE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:USPE_ECOLI pepnet swissprot:USPE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:USPE_ECOLI pepstats swissprot:USPE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:USPE_ECOLI pepwheel swissprot:USPE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:USPE_ECOLI pepwindow swissprot:USPE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:USPE_ECOLI sigcleave swissprot:USPE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:USPE_ECOLI ## Database ID URL or Descriptions # BioGrid 4259471 243 # CDD cd06174 MFS # EcoGene EG11636 sotB # FUNCTION SOTB_ECOLI Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites. Transports L-arabinose and to a lesser extent IPTG. Seems to contribute to the control of the arabinose regulon. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015144 carbohydrate transmembrane transporter activity; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # HAMAP MF_00517 MFS_SotB # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # InterPro IPR023495 Sugar_effux_transptr_put # KEGG_Brite ko02000 Transporters # Organism SOTB_ECOLI Escherichia coli (strain K12) # PATRIC 32118354 VBIEscCol129921_1597 # PIR C64907 C64907 # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SOTB_ECOLI Sugar efflux transporter # RefSeq NP_416045 NC_000913.3 # RefSeq WP_000210799 NZ_LN832404.1 # SIMILARITY Belongs to the major facilitator superfamily. SotB (TC 2.A.1.2) family. {ECO 0000305}. # SUBCELLULAR LOCATION SOTB_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.2.15 the major facilitator superfamily (mfs) # eggNOG COG2814 LUCA # eggNOG ENOG4105F27 Bacteria BLAST swissprot:SOTB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SOTB_ECOLI BioCyc ECOL316407:JW1521-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1521-MONOMER BioCyc EcoCyc:YDEA-MONOMER http://biocyc.org/getid?id=EcoCyc:YDEA-MONOMER BioCyc MetaCyc:YDEA-MONOMER http://biocyc.org/getid?id=MetaCyc:YDEA-MONOMER COG COG2814 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2814 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M96235 http://www.ebi.ac.uk/ena/data/view/M96235 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1592 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1592 EcoGene EG11636 http://www.ecogene.org/geneInfo.php?eg_id=EG11636 EnsemblBacteria AAC74601 http://www.ensemblgenomes.org/id/AAC74601 EnsemblBacteria AAC74601 http://www.ensemblgenomes.org/id/AAC74601 EnsemblBacteria BAA15210 http://www.ensemblgenomes.org/id/BAA15210 EnsemblBacteria BAA15210 http://www.ensemblgenomes.org/id/BAA15210 EnsemblBacteria BAA15210 http://www.ensemblgenomes.org/id/BAA15210 EnsemblBacteria b1528 http://www.ensemblgenomes.org/id/b1528 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015144 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015144 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GeneID 947218 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947218 HAMAP MF_00517 http://hamap.expasy.org/unirule/MF_00517 HOGENOM HOG000268498 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000268498&db=HOGENOM6 InParanoid P31122 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31122 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 InterPro IPR023495 http://www.ebi.ac.uk/interpro/entry/IPR023495 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1521 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1521 KEGG_Gene eco:b1528 http://www.genome.jp/dbget-bin/www_bget?eco:b1528 KEGG_Orthology KO:K08159 http://www.genome.jp/dbget-bin/www_bget?KO:K08159 OMA HMESAQA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HMESAQA PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:SOTB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SOTB_ECOLI PSORT-B swissprot:SOTB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SOTB_ECOLI PSORT2 swissprot:SOTB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SOTB_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:SOTB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SOTB_ECOLI PhylomeDB P31122 http://phylomedb.org/?seqid=P31122 ProteinModelPortal P31122 http://www.proteinmodelportal.org/query/uniprot/P31122 PubMed 10094697 http://www.ncbi.nlm.nih.gov/pubmed/10094697 PubMed 10438792 http://www.ncbi.nlm.nih.gov/pubmed/10438792 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8383113 http://www.ncbi.nlm.nih.gov/pubmed/8383113 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416045 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416045 RefSeq WP_000210799 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000210799 STRING 511145.b1528 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1528&targetmode=cogs STRING COG2814 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2814&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.2.15 http://www.tcdb.org/search/result.php?tc=2.A.1.2.15 UniProtKB SOTB_ECOLI http://www.uniprot.org/uniprot/SOTB_ECOLI UniProtKB-AC P31122 http://www.uniprot.org/uniprot/P31122 charge swissprot:SOTB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SOTB_ECOLI eggNOG COG2814 http://eggnogapi.embl.de/nog_data/html/tree/COG2814 eggNOG ENOG4105F27 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F27 epestfind swissprot:SOTB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SOTB_ECOLI garnier swissprot:SOTB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SOTB_ECOLI helixturnhelix swissprot:SOTB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SOTB_ECOLI hmoment swissprot:SOTB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SOTB_ECOLI iep swissprot:SOTB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SOTB_ECOLI inforesidue swissprot:SOTB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SOTB_ECOLI octanol swissprot:SOTB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SOTB_ECOLI pepcoil swissprot:SOTB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SOTB_ECOLI pepdigest swissprot:SOTB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SOTB_ECOLI pepinfo swissprot:SOTB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SOTB_ECOLI pepnet swissprot:SOTB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SOTB_ECOLI pepstats swissprot:SOTB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SOTB_ECOLI pepwheel swissprot:SOTB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SOTB_ECOLI pepwindow swissprot:SOTB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SOTB_ECOLI sigcleave swissprot:SOTB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SOTB_ECOLI ## Database ID URL or Descriptions # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG13309 ypjI # InterPro IPR009253 DUF905 # Organism YPJI_ECOLI Escherichia coli (strain K12) # Pfam PF06006 DUF905 # ProDom PD028015 DUF905_proteobac # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YPJI_ECOLI Putative UPF0401 protein YpjI # SEQUENCE CAUTION YPJI_ECOLI Sequence=AP009048; Type=Erroneous termination; Positions=8, 11; Note=Translated as Xaa, Xaa.; Evidence={ECO 0000305}; Sequence=AP009048; Type=Frameshift; Positions=60; Evidence={ECO 0000305}; Sequence=U00096; Type=Erroneous termination; Positions=8, 11; Note=Translated as Xaa, Xaa.; Evidence={ECO 0000305}; Sequence=U00096; Type=Frameshift; Positions=60; Evidence={ECO 0000305}; # SIMILARITY Belongs to the UPF0401 family. {ECO 0000305}. BLAST swissprot:YPJI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YPJI_ECOLI DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG13309 http://www.ecogene.org/geneInfo.php?eg_id=EG13309 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv HOGENOM HOG000266874 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000266874&db=HOGENOM6 InterPro IPR009253 http://www.ebi.ac.uk/interpro/entry/IPR009253 PSORT swissprot:YPJI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YPJI_ECOLI PSORT-B swissprot:YPJI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YPJI_ECOLI PSORT2 swissprot:YPJI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YPJI_ECOLI Pfam PF06006 http://pfam.xfam.org/family/PF06006 Phobius swissprot:YPJI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YPJI_ECOLI PhylomeDB P58095 http://phylomedb.org/?seqid=P58095 ProteinModelPortal P58095 http://www.proteinmodelportal.org/query/uniprot/P58095 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 UniProtKB YPJI_ECOLI http://www.uniprot.org/uniprot/YPJI_ECOLI UniProtKB-AC P58095 http://www.uniprot.org/uniprot/P58095 charge swissprot:YPJI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YPJI_ECOLI epestfind swissprot:YPJI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YPJI_ECOLI garnier swissprot:YPJI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YPJI_ECOLI helixturnhelix swissprot:YPJI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YPJI_ECOLI hmoment swissprot:YPJI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YPJI_ECOLI iep swissprot:YPJI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YPJI_ECOLI inforesidue swissprot:YPJI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YPJI_ECOLI octanol swissprot:YPJI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YPJI_ECOLI pepcoil swissprot:YPJI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YPJI_ECOLI pepdigest swissprot:YPJI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YPJI_ECOLI pepinfo swissprot:YPJI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YPJI_ECOLI pepnet swissprot:YPJI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YPJI_ECOLI pepstats swissprot:YPJI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YPJI_ECOLI pepwheel swissprot:YPJI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YPJI_ECOLI pepwindow swissprot:YPJI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YPJI_ECOLI sigcleave swissprot:YPJI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YPJI_ECOLI ## Database ID URL or Descriptions # AltName SYK2_ECOLI Lysyl-tRNA synthetase # BioGrid 4262688 6 # CATALYTIC ACTIVITY SYK2_ECOLI ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys). # CDD cd00775 LysRS_core # COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI 18420; Note=Binds 3 Mg(2+) ions per subunit. The third one is coordinated by ATP.; # EcoGene EG10553 lysU # FUNCTION SYK2_ECOLI Also can synthesize a number of adenyl dinucleotides (in particular AppppA). These dinucleotides have been proposed to act as modulators of the heat-shock response and stress response. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0000287 magnesium ion binding; IDA:EcoliWiki. # GO_function GO:0003676 nucleic acid binding; IEA:InterPro. # GO_function GO:0004824 lysine-tRNA ligase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IDA:EcoliWiki. # GO_function GO:0016874 ligase activity; IDA:EcoliWiki. # GO_process GO:0006418 tRNA aminoacylation for protein translation; IGI:EcoliWiki. # GO_process GO:0006430 lysyl-tRNA aminoacylation; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0006520 cellular amino acid metabolic process # HAMAP MF_00252 Lys_tRNA_synth_class2 # IntAct P0A8N5 51 # InterPro IPR002313 Lys-tRNA-ligase_II # InterPro IPR004364 aa-tRNA-synt_II # InterPro IPR004365 NA-bd_OB_tRNA # InterPro IPR006195 aa-tRNA-synth_II # InterPro IPR012340 NA-bd_OB-fold # InterPro IPR018149 Lys-tRNA-synth_II_C # InterPro IPR018150 aa-tRNA-synt_II-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01007 Amino acid related enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # KEGG_Pathway ko00970 Aminoacyl-tRNA biosynthesis # MISCELLANEOUS There are two lysyl-tRNA ligases in E.coli lysS is expressed constitutively, while lysU is heat inducible. # Organism SYK2_ECOLI Escherichia coli (strain K12) # PANTHER PTHR22594 PTHR22594 # PATRIC 32123825 VBIEscCol129921_4261 # PDB 1E1O X-ray; 2.12 A; A=2-505 # PDB 1E1T X-ray; 2.40 A; A=2-505 # PDB 1E22 X-ray; 2.43 A; A=2-505 # PDB 1E24 X-ray; 2.35 A; A=2-505 # PDB 1LYL X-ray; 2.80 A; A/B/C=2-505 # PIR S56358 SYECKU # PIRSF PIRSF039101 LysRS2 # PRINTS PR00982 TRNASYNTHLYS # PROSITE PS50862 AA_TRNA_LIGASE_II # Pfam PF00152 tRNA-synt_2 # Pfam PF01336 tRNA_anti-codon # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SYK2_ECOLI Lysine--tRNA ligase, heat inducible # RefSeq NP_418553 NC_000913.3 # RefSeq WP_001295074 NZ_LN832404.1 # SIMILARITY Belongs to the class-II aminoacyl-tRNA synthetase family. {ECO 0000305}. # SUBCELLULAR LOCATION SYK2_ECOLI Cytoplasm. # SUBUNIT SYK2_ECOLI Homodimer. # SUPFAM SSF50249 SSF50249 # TIGRFAMs TIGR00499 lysS_bact # eggNOG COG1190 LUCA # eggNOG ENOG4105CRK Bacteria BLAST swissprot:SYK2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SYK2_ECOLI BioCyc ECOL316407:JW4090-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4090-MONOMER BioCyc EcoCyc:LYSU-MONOMER http://biocyc.org/getid?id=EcoCyc:LYSU-MONOMER BioCyc MetaCyc:LYSU-MONOMER http://biocyc.org/getid?id=MetaCyc:LYSU-MONOMER COG COG1190 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1190 DIP DIP-36212N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36212N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/S0969-2126(01)00147-2 http://dx.doi.org/10.1016/S0969-2126(01)00147-2 DOI 10.1021/bi0006722 http://dx.doi.org/10.1021/bi0006722 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/nar/18.2.305 http://dx.doi.org/10.1093/nar/18.2.305 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.1.1.6 http://www.genome.jp/dbget-bin/www_bget?EC:6.1.1.6 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M30630 http://www.ebi.ac.uk/ena/data/view/M30630 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X16542 http://www.ebi.ac.uk/ena/data/view/X16542 ENZYME 6.1.1.6 http://enzyme.expasy.org/EC/6.1.1.6 EchoBASE EB0548 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0548 EcoGene EG10553 http://www.ecogene.org/geneInfo.php?eg_id=EG10553 EnsemblBacteria AAC77090 http://www.ensemblgenomes.org/id/AAC77090 EnsemblBacteria AAC77090 http://www.ensemblgenomes.org/id/AAC77090 EnsemblBacteria BAE78132 http://www.ensemblgenomes.org/id/BAE78132 EnsemblBacteria BAE78132 http://www.ensemblgenomes.org/id/BAE78132 EnsemblBacteria BAE78132 http://www.ensemblgenomes.org/id/BAE78132 EnsemblBacteria b4129 http://www.ensemblgenomes.org/id/b4129 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0003676 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003676 GO_function GO:0004824 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004824 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GO_process GO:0006418 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006418 GO_process GO:0006430 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006430 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GeneID 948645 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948645 HAMAP MF_00252 http://hamap.expasy.org/unirule/MF_00252 HOGENOM HOG000236578 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000236578&db=HOGENOM6 InParanoid P0A8N5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8N5 IntAct P0A8N5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8N5* IntEnz 6.1.1.6 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.1.1.6 InterPro IPR002313 http://www.ebi.ac.uk/interpro/entry/IPR002313 InterPro IPR004364 http://www.ebi.ac.uk/interpro/entry/IPR004364 InterPro IPR004365 http://www.ebi.ac.uk/interpro/entry/IPR004365 InterPro IPR006195 http://www.ebi.ac.uk/interpro/entry/IPR006195 InterPro IPR012340 http://www.ebi.ac.uk/interpro/entry/IPR012340 InterPro IPR018149 http://www.ebi.ac.uk/interpro/entry/IPR018149 InterPro IPR018150 http://www.ebi.ac.uk/interpro/entry/IPR018150 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW4090 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4090 KEGG_Gene eco:b4129 http://www.genome.jp/dbget-bin/www_bget?eco:b4129 KEGG_Orthology KO:K04567 http://www.genome.jp/dbget-bin/www_bget?KO:K04567 KEGG_Pathway ko00970 http://www.genome.jp/kegg-bin/show_pathway?ko00970 KEGG_Reaction rn:R03658 http://www.genome.jp/dbget-bin/www_bget?rn:R03658 MINT MINT-1219496 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1219496 OMA ANMFDEL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ANMFDEL PANTHER PTHR22594 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22594 PDB 1E1O http://www.ebi.ac.uk/pdbe-srv/view/entry/1E1O PDB 1E1T http://www.ebi.ac.uk/pdbe-srv/view/entry/1E1T PDB 1E22 http://www.ebi.ac.uk/pdbe-srv/view/entry/1E22 PDB 1E24 http://www.ebi.ac.uk/pdbe-srv/view/entry/1E24 PDB 1LYL http://www.ebi.ac.uk/pdbe-srv/view/entry/1LYL PDBsum 1E1O http://www.ebi.ac.uk/pdbsum/1E1O PDBsum 1E1T http://www.ebi.ac.uk/pdbsum/1E1T PDBsum 1E22 http://www.ebi.ac.uk/pdbsum/1E22 PDBsum 1E24 http://www.ebi.ac.uk/pdbsum/1E24 PDBsum 1LYL http://www.ebi.ac.uk/pdbsum/1LYL PRINTS PR00982 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00982 PROSITE PS50862 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50862 PSORT swissprot:SYK2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SYK2_ECOLI PSORT-B swissprot:SYK2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SYK2_ECOLI PSORT2 swissprot:SYK2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SYK2_ECOLI Pfam PF00152 http://pfam.xfam.org/family/PF00152 Pfam PF01336 http://pfam.xfam.org/family/PF01336 Phobius swissprot:SYK2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SYK2_ECOLI PhylomeDB P0A8N5 http://phylomedb.org/?seqid=P0A8N5 ProteinModelPortal P0A8N5 http://www.proteinmodelportal.org/query/uniprot/P0A8N5 PubMed 10913247 http://www.ncbi.nlm.nih.gov/pubmed/10913247 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 2183178 http://www.ncbi.nlm.nih.gov/pubmed/2183178 PubMed 2188953 http://www.ncbi.nlm.nih.gov/pubmed/2188953 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 7735833 http://www.ncbi.nlm.nih.gov/pubmed/7735833 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_418553 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418553 RefSeq WP_001295074 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295074 SMR P0A8N5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8N5 STRING 511145.b4129 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4129&targetmode=cogs STRING COG1190 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1190&targetmode=cogs SUPFAM SSF50249 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50249 TIGRFAMs TIGR00499 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00499 UniProtKB SYK2_ECOLI http://www.uniprot.org/uniprot/SYK2_ECOLI UniProtKB-AC P0A8N5 http://www.uniprot.org/uniprot/P0A8N5 charge swissprot:SYK2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SYK2_ECOLI eggNOG COG1190 http://eggnogapi.embl.de/nog_data/html/tree/COG1190 eggNOG ENOG4105CRK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CRK epestfind swissprot:SYK2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SYK2_ECOLI garnier swissprot:SYK2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SYK2_ECOLI helixturnhelix swissprot:SYK2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SYK2_ECOLI hmoment swissprot:SYK2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SYK2_ECOLI iep swissprot:SYK2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SYK2_ECOLI inforesidue swissprot:SYK2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SYK2_ECOLI octanol swissprot:SYK2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SYK2_ECOLI pepcoil swissprot:SYK2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SYK2_ECOLI pepdigest swissprot:SYK2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SYK2_ECOLI pepinfo swissprot:SYK2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SYK2_ECOLI pepnet swissprot:SYK2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SYK2_ECOLI pepstats swissprot:SYK2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SYK2_ECOLI pepwheel swissprot:SYK2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SYK2_ECOLI pepwindow swissprot:SYK2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SYK2_ECOLI sigcleave swissprot:SYK2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SYK2_ECOLI ## Database ID URL or Descriptions # BioGrid 4261741 20 # COFACTOR Name=FMN; Xref=ChEBI:CHEBI 58210; Evidence={ECO:0000250}; # EcoGene EG13170 yqcA # FUNCTION YQCA_ECOLI Probable electron transporter. # GO_function GO:0010181 FMN binding; IDA:EcoCyc. # GO_process GO:0055114 oxidation-reduction process; IEA:UniProtKB-KW. # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.360 -; 1. # IntAct P65367 6 # InterPro IPR001094 Flavdoxin-like # InterPro IPR008254 Flavodoxin/NO_synth # InterPro IPR029039 Flavoprotein-like_dom # Organism YQCA_ECOLI Escherichia coli (strain K12) # PATRIC 32120996 VBIEscCol129921_2890 # PIR B65061 B65061 # PRINTS PR00369 FLAVODOXIN # PROSITE PS50902 FLAVODOXIN_LIKE # Pfam PF00258 Flavodoxin_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQCA_ECOLI Uncharacterized protein YqcA # RefSeq NP_417270 NC_000913.3 # RefSeq WP_000807753 NZ_LN832404.1 # SIMILARITY Belongs to the flavodoxin family. MioC subfamily. {ECO 0000305}. # SIMILARITY Contains 1 flavodoxin-like domain. {ECO:0000255|PROSITE-ProRule PRU00088}. # SUPFAM SSF52218 SSF52218 # eggNOG COG0716 LUCA # eggNOG ENOG4105QDK Bacteria BLAST swissprot:YQCA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQCA_ECOLI BioCyc ECOL316407:JW2761-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2761-MONOMER BioCyc EcoCyc:G7448-MONOMER http://biocyc.org/getid?id=EcoCyc:G7448-MONOMER DIP DIP-48153N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48153N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 EchoBASE EB2962 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2962 EcoGene EG13170 http://www.ecogene.org/geneInfo.php?eg_id=EG13170 EnsemblBacteria AAC75832 http://www.ensemblgenomes.org/id/AAC75832 EnsemblBacteria AAC75832 http://www.ensemblgenomes.org/id/AAC75832 EnsemblBacteria BAE76862 http://www.ensemblgenomes.org/id/BAE76862 EnsemblBacteria BAE76862 http://www.ensemblgenomes.org/id/BAE76862 EnsemblBacteria BAE76862 http://www.ensemblgenomes.org/id/BAE76862 EnsemblBacteria b2790 http://www.ensemblgenomes.org/id/b2790 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0010181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010181 GO_process GO:0055114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.360 http://www.cathdb.info/version/latest/superfamily/3.40.50.360 GeneID 947151 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947151 HOGENOM HOG000030545 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000030545&db=HOGENOM6 InParanoid P65367 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P65367 IntAct P65367 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P65367* InterPro IPR001094 http://www.ebi.ac.uk/interpro/entry/IPR001094 InterPro IPR008254 http://www.ebi.ac.uk/interpro/entry/IPR008254 InterPro IPR029039 http://www.ebi.ac.uk/interpro/entry/IPR029039 KEGG_Gene ecj:JW2761 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2761 KEGG_Gene eco:b2790 http://www.genome.jp/dbget-bin/www_bget?eco:b2790 OMA YQPELRY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YQPELRY PRINTS PR00369 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00369 PROSITE PS50902 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50902 PSORT swissprot:YQCA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQCA_ECOLI PSORT-B swissprot:YQCA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQCA_ECOLI PSORT2 swissprot:YQCA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQCA_ECOLI Pfam PF00258 http://pfam.xfam.org/family/PF00258 Phobius swissprot:YQCA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQCA_ECOLI PhylomeDB P65367 http://phylomedb.org/?seqid=P65367 ProteinModelPortal P65367 http://www.proteinmodelportal.org/query/uniprot/P65367 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417270 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417270 RefSeq WP_000807753 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000807753 SMR P65367 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P65367 STRING 511145.b2790 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2790&targetmode=cogs SUPFAM SSF52218 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52218 UniProtKB YQCA_ECOLI http://www.uniprot.org/uniprot/YQCA_ECOLI UniProtKB-AC P65367 http://www.uniprot.org/uniprot/P65367 charge swissprot:YQCA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQCA_ECOLI eggNOG COG0716 http://eggnogapi.embl.de/nog_data/html/tree/COG0716 eggNOG ENOG4105QDK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105QDK epestfind swissprot:YQCA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQCA_ECOLI garnier swissprot:YQCA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQCA_ECOLI helixturnhelix swissprot:YQCA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQCA_ECOLI hmoment swissprot:YQCA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQCA_ECOLI iep swissprot:YQCA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQCA_ECOLI inforesidue swissprot:YQCA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQCA_ECOLI octanol swissprot:YQCA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQCA_ECOLI pepcoil swissprot:YQCA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQCA_ECOLI pepdigest swissprot:YQCA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQCA_ECOLI pepinfo swissprot:YQCA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQCA_ECOLI pepnet swissprot:YQCA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQCA_ECOLI pepstats swissprot:YQCA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQCA_ECOLI pepwheel swissprot:YQCA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQCA_ECOLI pepwindow swissprot:YQCA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQCA_ECOLI sigcleave swissprot:YQCA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQCA_ECOLI ## Database ID URL or Descriptions # AltName APAH_ECOLI Ap4A hydrolase # AltName APAH_ECOLI Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase # AltName APAH_ECOLI Diadenosine tetraphosphatase # BioGrid 4262205 12 # CATALYTIC ACTIVITY P(1),P(4)-bis(5'-adenosyl) tetraphosphate + H(2)O = 2 ADP. {ECO:0000269|PubMed 6317672}. # CDD cd07422 MPP_ApaH # ENZYME REGULATION Co(2+) is a strong stimulator (100-fold increase in rate of hydrolysis). Mn(2+), Cd(2+), Ni(2+), Mg(2+) and Ca(2+) are weak stimulators; the two latter act synergistically with Co(2+). {ECO:0000269|PubMed 6317672}. # EcoGene EG10048 apaH # FUNCTION APAH_ECOLI Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP. {ECO 0000269|PubMed 6317672}. # GO_function GO:0008796 bis(5'-nucleosyl)-tetraphosphatase activity; IMP:EcoliWiki. # GO_function GO:0008803 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity; IDA:EcoliWiki. # GO_process GO:0015949 nucleobase-containing small molecule interconversion; IMP:EcoliWiki. # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.60.21.10 -; 2. # HAMAP MF_00199 ApaH # IntAct P05637 5 # InterPro IPR004617 ApaH # InterPro IPR004843 Calcineurin-like_PHP_ApaH # InterPro IPR029052 Metallo-depent_PP-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # Organism APAH_ECOLI Escherichia coli (strain K12) # PATRIC 32115197 VBIEscCol129921_0050 # PIR A64726 A64726 # PIRSF PIRSF000903 B5n-ttraPtase_sm # Pfam PF00149 Metallophos # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName APAH_ECOLI Bis(5'-nucleosyl)-tetraphosphatase [symmetrical] # RefSeq NP_414591 NC_000913.3 # RefSeq WP_000257192 NZ_LN832404.1 # SIMILARITY Belongs to the Ap4A hydrolase family. {ECO 0000305}. # SUBUNIT Monomer. {ECO:0000269|PubMed 6317672}. # SUPFAM SSF56300 SSF56300 # TIGRFAMs TIGR00668 apaH # eggNOG COG0639 LUCA # eggNOG ENOG4105DDT Bacteria BLAST swissprot:APAH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:APAH_ECOLI BioCyc ECOL316407:JW0048-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0048-MONOMER BioCyc EcoCyc:EG10048-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10048-MONOMER BioCyc MetaCyc:EG10048-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10048-MONOMER COG COG0639 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0639 DIP DIP-9113N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9113N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1007/BF00338091 http://dx.doi.org/10.1007/BF00338091 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.1.41 http://www.genome.jp/dbget-bin/www_bget?EC:3.6.1.41 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X04711 http://www.ebi.ac.uk/ena/data/view/X04711 ENZYME 3.6.1.41 http://enzyme.expasy.org/EC/3.6.1.41 EchoBASE EB0046 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0046 EcoGene EG10048 http://www.ecogene.org/geneInfo.php?eg_id=EG10048 EnsemblBacteria AAC73160 http://www.ensemblgenomes.org/id/AAC73160 EnsemblBacteria AAC73160 http://www.ensemblgenomes.org/id/AAC73160 EnsemblBacteria BAB96617 http://www.ensemblgenomes.org/id/BAB96617 EnsemblBacteria BAB96617 http://www.ensemblgenomes.org/id/BAB96617 EnsemblBacteria BAB96617 http://www.ensemblgenomes.org/id/BAB96617 EnsemblBacteria b0049 http://www.ensemblgenomes.org/id/b0049 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008796 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008796 GO_function GO:0008803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008803 GO_process GO:0015949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015949 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.60.21.10 http://www.cathdb.info/version/latest/superfamily/3.60.21.10 GeneID 944770 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944770 HAMAP MF_00199 http://hamap.expasy.org/unirule/MF_00199 HOGENOM HOG000251871 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000251871&db=HOGENOM6 InParanoid P05637 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P05637 IntAct P05637 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P05637* IntEnz 3.6.1.41 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.1.41 InterPro IPR004617 http://www.ebi.ac.uk/interpro/entry/IPR004617 InterPro IPR004843 http://www.ebi.ac.uk/interpro/entry/IPR004843 InterPro IPR029052 http://www.ebi.ac.uk/interpro/entry/IPR029052 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0048 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0048 KEGG_Gene eco:b0049 http://www.genome.jp/dbget-bin/www_bget?eco:b0049 KEGG_Orthology KO:K01525 http://www.genome.jp/dbget-bin/www_bget?KO:K01525 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Reaction rn:R00125 http://www.genome.jp/dbget-bin/www_bget?rn:R00125 OMA INAFTRM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=INAFTRM PSORT swissprot:APAH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:APAH_ECOLI PSORT-B swissprot:APAH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:APAH_ECOLI PSORT2 swissprot:APAH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:APAH_ECOLI Pfam PF00149 http://pfam.xfam.org/family/PF00149 Phobius swissprot:APAH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:APAH_ECOLI PhylomeDB P05637 http://phylomedb.org/?seqid=P05637 ProteinModelPortal P05637 http://www.proteinmodelportal.org/query/uniprot/P05637 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3031429 http://www.ncbi.nlm.nih.gov/pubmed/3031429 PubMed 6317672 http://www.ncbi.nlm.nih.gov/pubmed/6317672 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_414591 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414591 RefSeq WP_000257192 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000257192 SMR P05637 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P05637 STRING 511145.b0049 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0049&targetmode=cogs STRING COG0639 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0639&targetmode=cogs SUPFAM SSF56300 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56300 TIGRFAMs TIGR00668 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00668 UniProtKB APAH_ECOLI http://www.uniprot.org/uniprot/APAH_ECOLI UniProtKB-AC P05637 http://www.uniprot.org/uniprot/P05637 charge swissprot:APAH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:APAH_ECOLI eggNOG COG0639 http://eggnogapi.embl.de/nog_data/html/tree/COG0639 eggNOG ENOG4105DDT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DDT epestfind swissprot:APAH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:APAH_ECOLI garnier swissprot:APAH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:APAH_ECOLI helixturnhelix swissprot:APAH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:APAH_ECOLI hmoment swissprot:APAH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:APAH_ECOLI iep swissprot:APAH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:APAH_ECOLI inforesidue swissprot:APAH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:APAH_ECOLI octanol swissprot:APAH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:APAH_ECOLI pepcoil swissprot:APAH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:APAH_ECOLI pepdigest swissprot:APAH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:APAH_ECOLI pepinfo swissprot:APAH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:APAH_ECOLI pepnet swissprot:APAH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:APAH_ECOLI pepstats swissprot:APAH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:APAH_ECOLI pepwheel swissprot:APAH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:APAH_ECOLI pepwindow swissprot:APAH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:APAH_ECOLI sigcleave swissprot:APAH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:APAH_ECOLI ## Database ID URL or Descriptions # AltName NEMA_ECOLI N-ethylmaleimide reducing enzyme # BioGrid 4259388 16 # COFACTOR Name=FMN; Xref=ChEBI:CHEBI 58210; Evidence={ECO:0000250}; # EcoGene EG13546 nemA # FUNCTION NEMA_ECOLI Catalyzes the reduction of N-ethylmaleimide (NEM) to N- ethylsuccinimide. {ECO 0000269|PubMed 9013822}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003959 NADPH dehydrogenase activity; IBA:GO_Central. # GO_function GO:0008748 N-ethylmaleimide reductase activity; IDA:EcoCyc. # GO_function GO:0010181 FMN binding; IDA:EcoCyc. # GO_function GO:0034567 chromate reductase activity; IDA:EcoCyc. # GO_function GO:0046857 oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor; IDA:EcoCyc. # GO_process GO:0006805 xenobiotic metabolic process; IDA:EcoCyc. # GO_process GO:0018937 nitroglycerin metabolic process; IDA:EcoCyc. # GO_process GO:0046256 2,4,6-trinitrotoluene catabolic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # Gene3D 3.20.20.70 -; 1. # INDUCTION Repressed by NemR. Induced by N-ethylmaleimide, probably via inactivation of NemR. {ECO:0000269|PubMed 18567656}. # IntAct P77258 3 # InterPro IPR001155 OxRdtase_FMN_N # InterPro IPR013785 Aldolase_TIM # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00633 Nitrotoluene degradation # Organism NEMA_ECOLI Escherichia coli (strain K12) # PATRIC 32118602 VBIEscCol129921_1721 # PIR JC5605 JC5605 # Pfam PF00724 Oxidored_FMN # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NEMA_ECOLI N-ethylmaleimide reductase # RefSeq NP_416167 NC_000913.3 # RefSeq WP_000093589 NZ_LN832404.1 # SIMILARITY Belongs to the NADH:flavin oxidoreductase/NADH oxidase family. {ECO 0000305}. # eggNOG COG1902 LUCA # eggNOG ENOG4105CCY Bacteria BLAST swissprot:NEMA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NEMA_ECOLI BioCyc ECOL316407:JW1642-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1642-MONOMER BioCyc EcoCyc:G6890-MONOMER http://biocyc.org/getid?id=EcoCyc:G6890-MONOMER BioCyc MetaCyc:G6890-MONOMER http://biocyc.org/getid?id=MetaCyc:G6890-MONOMER COG COG1902 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1902 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00459-08 http://dx.doi.org/10.1128/JB.00459-08 DOI 10.1248/bpb.20.110 http://dx.doi.org/10.1248/bpb.20.110 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D86931 http://www.ebi.ac.uk/ena/data/view/D86931 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- EchoBASE EB3316 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3316 EcoGene EG13546 http://www.ecogene.org/geneInfo.php?eg_id=EG13546 EnsemblBacteria AAC74722 http://www.ensemblgenomes.org/id/AAC74722 EnsemblBacteria AAC74722 http://www.ensemblgenomes.org/id/AAC74722 EnsemblBacteria BAE76493 http://www.ensemblgenomes.org/id/BAE76493 EnsemblBacteria BAE76493 http://www.ensemblgenomes.org/id/BAE76493 EnsemblBacteria BAE76493 http://www.ensemblgenomes.org/id/BAE76493 EnsemblBacteria b1650 http://www.ensemblgenomes.org/id/b1650 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003959 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003959 GO_function GO:0008748 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008748 GO_function GO:0010181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010181 GO_function GO:0034567 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034567 GO_function GO:0046857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046857 GO_process GO:0006805 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006805 GO_process GO:0018937 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018937 GO_process GO:0046256 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046256 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 946164 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946164 HOGENOM HOG000116231 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000116231&db=HOGENOM6 InParanoid P77258 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77258 IntAct P77258 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77258* IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR001155 http://www.ebi.ac.uk/interpro/entry/IPR001155 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1642 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1642 KEGG_Gene eco:b1650 http://www.genome.jp/dbget-bin/www_bget?eco:b1650 KEGG_Orthology KO:K10680 http://www.genome.jp/dbget-bin/www_bget?KO:K10680 KEGG_Pathway ko00633 http://www.genome.jp/kegg-bin/show_pathway?ko00633 KEGG_Reaction rn:R08014 http://www.genome.jp/dbget-bin/www_bget?rn:R08014 KEGG_Reaction rn:R08017 http://www.genome.jp/dbget-bin/www_bget?rn:R08017 KEGG_Reaction rn:R08042 http://www.genome.jp/dbget-bin/www_bget?rn:R08042 OMA RFRQNAP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RFRQNAP PSORT swissprot:NEMA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NEMA_ECOLI PSORT-B swissprot:NEMA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NEMA_ECOLI PSORT2 swissprot:NEMA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NEMA_ECOLI Pfam PF00724 http://pfam.xfam.org/family/PF00724 Phobius swissprot:NEMA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NEMA_ECOLI PhylomeDB P77258 http://phylomedb.org/?seqid=P77258 ProteinModelPortal P77258 http://www.proteinmodelportal.org/query/uniprot/P77258 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18567656 http://www.ncbi.nlm.nih.gov/pubmed/18567656 PubMed 9013822 http://www.ncbi.nlm.nih.gov/pubmed/9013822 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416167 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416167 RefSeq WP_000093589 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000093589 SMR P77258 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77258 STRING 511145.b1650 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1650&targetmode=cogs STRING COG1902 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1902&targetmode=cogs SWISS-2DPAGE P77258 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P77258 UniProtKB NEMA_ECOLI http://www.uniprot.org/uniprot/NEMA_ECOLI UniProtKB-AC P77258 http://www.uniprot.org/uniprot/P77258 charge swissprot:NEMA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NEMA_ECOLI eggNOG COG1902 http://eggnogapi.embl.de/nog_data/html/tree/COG1902 eggNOG ENOG4105CCY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CCY epestfind swissprot:NEMA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NEMA_ECOLI garnier swissprot:NEMA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NEMA_ECOLI helixturnhelix swissprot:NEMA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NEMA_ECOLI hmoment swissprot:NEMA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NEMA_ECOLI iep swissprot:NEMA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NEMA_ECOLI inforesidue swissprot:NEMA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NEMA_ECOLI octanol swissprot:NEMA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NEMA_ECOLI pepcoil swissprot:NEMA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NEMA_ECOLI pepdigest swissprot:NEMA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NEMA_ECOLI pepinfo swissprot:NEMA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NEMA_ECOLI pepnet swissprot:NEMA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NEMA_ECOLI pepstats swissprot:NEMA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NEMA_ECOLI pepwheel swissprot:NEMA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NEMA_ECOLI pepwindow swissprot:NEMA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NEMA_ECOLI sigcleave swissprot:NEMA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NEMA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261936 14 # EcoGene EG14384 yaaX # IntAct P75616 4 # InterPro IPR019638 DUF2502 # Organism YAAX_ECOLI Escherichia coli (strain K12) # PATRIC 32115105 VBIEscCol129921_0004 # PIR E64720 E64720 # Pfam PF10697 DUF2502 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAAX_ECOLI Uncharacterized protein YaaX # RefSeq NP_414546 NC_000913.3 # RefSeq WP_000738719 NZ_LN832404.1 # SIMILARITY To E.coli YpeC. {ECO 0000305}. # eggNOG ENOG41062C6 Bacteria # eggNOG ENOG4112AV1 LUCA BLAST swissprot:YAAX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAAX_ECOLI BioCyc ECOL316407:JW0004-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0004-MONOMER BioCyc EcoCyc:G6081-MONOMER http://biocyc.org/getid?id=EcoCyc:G6081-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4127 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4127 EcoGene EG14384 http://www.ecogene.org/geneInfo.php?eg_id=EG14384 EnsemblBacteria AAC73116 http://www.ensemblgenomes.org/id/AAC73116 EnsemblBacteria AAC73116 http://www.ensemblgenomes.org/id/AAC73116 EnsemblBacteria BAB96582 http://www.ensemblgenomes.org/id/BAB96582 EnsemblBacteria BAB96582 http://www.ensemblgenomes.org/id/BAB96582 EnsemblBacteria BAB96582 http://www.ensemblgenomes.org/id/BAB96582 EnsemblBacteria b0005 http://www.ensemblgenomes.org/id/b0005 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 944747 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944747 HOGENOM HOG000116685 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000116685&db=HOGENOM6 IntAct P75616 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75616* InterPro IPR019638 http://www.ebi.ac.uk/interpro/entry/IPR019638 KEGG_Gene ecj:JW0004 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0004 KEGG_Gene eco:b0005 http://www.genome.jp/dbget-bin/www_bget?eco:b0005 OMA GPPGHWR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GPPGHWR PSORT swissprot:YAAX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAAX_ECOLI PSORT-B swissprot:YAAX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAAX_ECOLI PSORT2 swissprot:YAAX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAAX_ECOLI Pfam PF10697 http://pfam.xfam.org/family/PF10697 Phobius swissprot:YAAX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAAX_ECOLI ProteinModelPortal P75616 http://www.proteinmodelportal.org/query/uniprot/P75616 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414546 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414546 RefSeq WP_000738719 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000738719 STRING 511145.b0005 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0005&targetmode=cogs UniProtKB YAAX_ECOLI http://www.uniprot.org/uniprot/YAAX_ECOLI UniProtKB-AC P75616 http://www.uniprot.org/uniprot/P75616 charge swissprot:YAAX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAAX_ECOLI eggNOG ENOG41062C6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41062C6 eggNOG ENOG4112AV1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4112AV1 epestfind swissprot:YAAX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAAX_ECOLI garnier swissprot:YAAX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAAX_ECOLI helixturnhelix swissprot:YAAX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAAX_ECOLI hmoment swissprot:YAAX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAAX_ECOLI iep swissprot:YAAX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAAX_ECOLI inforesidue swissprot:YAAX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAAX_ECOLI octanol swissprot:YAAX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAAX_ECOLI pepcoil swissprot:YAAX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAAX_ECOLI pepdigest swissprot:YAAX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAAX_ECOLI pepinfo swissprot:YAAX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAAX_ECOLI pepnet swissprot:YAAX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAAX_ECOLI pepstats swissprot:YAAX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAAX_ECOLI pepwheel swissprot:YAAX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAAX_ECOLI pepwindow swissprot:YAAX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAAX_ECOLI sigcleave swissprot:YAAX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAAX_ECOLI ## Database ID URL or Descriptions # AltName Bacteriophage Q beta RNA-directed RNA polymerase subunit III {ECO:0000303|PubMed 816798} # AltName EFTU1_ECOLI P-43 # CAUTION EF-Tu 1 and EF-Tu 2 differ in a single position and are no longer merged. However, many papers are found in both entries as it is not always possible to determine for each paper which of EF-Tu 1 or EF-Tu 2 was being worked upon. {ECO 0000305}. # CDD cd03697 EFTU_II # EcoGene EG11036 tufA # FUNCTION EFTU1_ECOLI In case of infection by bacteriophage Qbeta, part of the viral RNA-dependent RNA polymerase complex. With EF-Ts may provide a stabilizing scaffold for the beta (catalytic) subunit. Helps separate the double-stranded RNA of the template and growing RNA during elongation. With the beta subunit helps form the exit tunnel for template RNA. {ECO 0000269|PubMed 816798, ECO 0000305}. # FUNCTION EFTU1_ECOLI May play an important regulatory role in cell growth and in the bacterial response to nutrient deprivation. # FUNCTION EFTU1_ECOLI Plays a stimulatory role in trans-translation; binds tmRNA. {ECO 0000269|PubMed 15069072}. # FUNCTION EFTU1_ECOLI This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. # GO_component GO:0005737 cytoplasm; IDA:UniProtKB. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_function GO:0003746 translation elongation factor activity; IBA:GO_Central. # GO_function GO:0003924 GTPase activity; IBA:GO_Central. # GO_function GO:0005525 GTP binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006414 translational elongation; IBA:GO_Central. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003924 GTPase activity # GOslim_function GO:0008135 translation factor activity, RNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.300 -; 1. # HAMAP MF_00118_B EF_Tu_B # INTERACTION EFTU1_ECOLI P15038 helD; NbExp=2; IntAct=EBI-301077, EBI-551473; P0A6Y5 hslO; NbExp=2; IntAct=EBI-301077, EBI-562857; P10441 lpxB; NbExp=2; IntAct=EBI-301077, EBI-553692; P77756 queC; NbExp=2; IntAct=EBI-301077, EBI-560024; P0A6P1 tsf; NbExp=7; IntAct=EBI-301077, EBI-301164; P0A8J4 ybeD; NbExp=2; IntAct=EBI-301077, EBI-370708; P63389 yheS; NbExp=2; IntAct=EBI-301077, EBI-561198; # IntAct P0CE47 156 # InterPro IPR000795 TF_GTP-bd_dom # InterPro IPR004160 Transl_elong_EFTu/EF1A_C # InterPro IPR004161 EFTu-like_2 # InterPro IPR004541 Transl_elong_EFTu/EF1A_bac/org # InterPro IPR005225 Small_GTP-bd_dom # InterPro IPR009000 Transl_B-barrel # InterPro IPR009001 Transl_elong_EF1A/Init_IF2_C # InterPro IPR027417 P-loop_NTPase # InterPro IPR031157 G_TR_CS # InterPro IPR033720 EFTU_2 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko03012 Translation factors # KEGG_Pathway ko04626 Plant-pathogen interaction # MISCELLANEOUS EFTU1_ECOLI This chain is also used in bacteriophage Q-beta RNA polymerase. # MISCELLANEOUS Present with about 70,000 molecules/cell. {ECO:0000305|PubMed 775340}. # MISCELLANEOUS The antibiotic kirromycin inhibits protein biosynthesis by inhibiting the release of EF-Tu from the ribosome. {ECO:0000269|PubMed 7525272}. # MISCELLANEOUS The antibiotic pulvomycin inhibits protein biosynthesis by disrupting the allosteric control mechanism of EF- Tu. {ECO:0000269|PubMed 7957075}. # Organism EFTU1_ECOLI Escherichia coli (strain K12) # PATRIC 32122110 VBIEscCol129921_3432 # PDB 1D8T X-ray; 2.35 A; A/B=2-394 # PDB 1EFC X-ray; 2.05 A; A/B=2-393 # PDB 1ETU X-ray; 2.90 A; A=2-394 # PDB 1MJ1 EM; 13.00 A; A=8-389 # PDB 2FX3 X-ray; 3.40 A; A=2-394 # PDB 2HCJ X-ray; 2.12 A; A=9-45, B=60-394 # PDB 2HDN X-ray; 2.80 A; A/C/E/G/I/K=9-45, B/D/F/H/J/L=60-394 # PDB 3EP2 EM; -; X=2-393 # PDB 3EQ3 EM; -; X=2-393 # PDB 3EQ4 EM; -; X=2-393 # PDB 3U2Q X-ray; 2.70 A; A=3-394 # PDB 3U6B X-ray; 2.12 A; A/B=3-394 # PDB 3U6K X-ray; 2.45 A; A/B=3-394 # PDB 4G5G X-ray; 2.30 A; A=3-394 # PDB 4PC3 X-ray; 1.83 A; A/B=1-394 # PDB 4PC7 X-ray; 3.60 A; A=1-394 # PDB 4Q7J X-ray; 2.90 A; B/F=2-394 # PDB 4V69 EM; 6.70 A; AZ=2-393 # PDB 5JBQ X-ray; 2.01 A; A=1-394 # PIR A91475 EFECTA # PRINTS PR00315 ELONGATNFCT # PROSITE PS00301 G_TR_1 # PROSITE PS51722 G_TR_2 # PTM EFTU1_ECOLI Methylated in vivo on Lys-57 in response to nutrient starvation. {ECO 0000269|PubMed 2022614, ECO 0000269|PubMed 389663, ECO 0000269|PubMed 6997043, ECO 0000269|PubMed 7021545}. # PTM EFTU1_ECOLI Phosphorylated in vitro by HipA on Thr-383 (PubMed 19150849), this has since been reported not to occur in vivo (PubMed 24095282). {ECO 0000269|PubMed 19150849, ECO 0000269|PubMed 24095282, ECO 0000269|PubMed 24141193, ECO 0000269|PubMed 8416965}. # PTM EFTU1_ECOLI Phosphorylated in vitro by phage protein doc on Thr-383. {ECO 0000269|PubMed 19150849, ECO 0000269|PubMed 24141193, ECO 0000269|PubMed 8416965}. # PTM EFTU1_ECOLI The N-terminus is blocked. # Pfam PF03143 GTP_EFTU_D3 # Pfam PF03144 GTP_EFTU_D2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Elongation factor Tu 1 {ECO:0000255|HAMAP-Rule MF_00118} # RefSeq NP_417798 NC_000913.3 # RefSeq WP_000031783 NZ_LN832404.1 # SIMILARITY Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. {ECO:0000255|HAMAP-Rule MF_00118}. # SIMILARITY Contains 1 tr-type G (guanine nucleotide-binding) domain. {ECO 0000305}. # SUBCELLULAR LOCATION EFTU1_ECOLI Cytoplasm. Cell inner membrane; Peripheral membrane protein. Note=Between 50-80% of the protein is associated with the cell inner membrane. Localization to the membrane has been suggested to follow nutrient stress. # SUBUNIT EFTU1_ECOLI Monomer. In case of infection by bacteriophage Qbeta, part of the viral RNA-dependent RNA polymerase complex, the other subunits are the viral replicase catalytic subunit (AC P14647), host ribosomal protein S1 and EF-Ts (PubMed 816798). {ECO 0000255|HAMAP-Rule MF_00118, ECO 0000269|PubMed 10625477, ECO 0000269|PubMed 17057344, ECO 0000269|PubMed 816798, ECO 0000269|PubMed 9918724, ECO 0000305}. # SUPFAM SSF50447 SSF50447 # SUPFAM SSF50465 SSF50465 # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR00231 small_GTP # TIGRFAMs TIGR00485 EF-Tu # eggNOG COG0050 LUCA # eggNOG ENOG4105CGV Bacteria BLAST swissprot:EFTU1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EFTU1_ECOLI BioCyc EcoCyc:EG11036-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11036-MONOMER COG COG0050 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0050 DIP DIP-6159N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-6159N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1998.2387 http://dx.doi.org/10.1006/jmbi.1998.2387 DOI 10.1016/0003-9861(89)90452-9 http://dx.doi.org/10.1016/0003-9861(89)90452-9 DOI 10.1016/0014-5793(79)80407-X http://dx.doi.org/10.1016/0014-5793(79)80407-X DOI 10.1016/0378-1119(80)90012-8 http://dx.doi.org/10.1016/0378-1119(80)90012-8 DOI 10.1016/j.molcel.2013.08.045 http://dx.doi.org/10.1016/j.molcel.2013.08.045 DOI 10.1021/bi9913597 http://dx.doi.org/10.1021/bi9913597 DOI 10.1038/261023a0 http://dx.doi.org/10.1038/261023a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nchembio.1364 http://dx.doi.org/10.1038/nchembio.1364 DOI 10.1074/jbc.273.8.4556 http://dx.doi.org/10.1074/jbc.273.8.4556 DOI 10.1074/jbc.M314086200 http://dx.doi.org/10.1074/jbc.M314086200 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1107/S0907444906004021 http://dx.doi.org/10.1107/S0907444906004021 DOI 10.1107/S0907444906035426 http://dx.doi.org/10.1107/S0907444906035426 DOI 10.1111/j.1432-1033.1980.tb04748.x http://dx.doi.org/10.1111/j.1432-1033.1980.tb04748.x DOI 10.1111/j.1432-1033.1989.tb15121.x http://dx.doi.org/10.1111/j.1432-1033.1989.tb15121.x DOI 10.1126/science.1163806 http://dx.doi.org/10.1126/science.1163806 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AF058450 http://www.ebi.ac.uk/ena/data/view/AF058450 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01690 http://www.ebi.ac.uk/ena/data/view/J01690 EMBL M10459 http://www.ebi.ac.uk/ena/data/view/M10459 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB1029 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1029 EcoGene EG11036 http://www.ecogene.org/geneInfo.php?eg_id=EG11036 EnsemblBacteria AAC76364 http://www.ensemblgenomes.org/id/AAC76364 EnsemblBacteria AAC76364 http://www.ensemblgenomes.org/id/AAC76364 EnsemblBacteria BAE77952 http://www.ensemblgenomes.org/id/BAE77952 EnsemblBacteria BAE77952 http://www.ensemblgenomes.org/id/BAE77952 EnsemblBacteria BAE77952 http://www.ensemblgenomes.org/id/BAE77952 EnsemblBacteria b3339 http://www.ensemblgenomes.org/id/b3339 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0003746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003746 GO_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_process GO:0006414 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006414 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GOslim_function GO:0008135 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008135 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947838 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947838 HAMAP MF_00118_B http://hamap.expasy.org/unirule/MF_00118_B InParanoid P0CE47 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CE47 IntAct P0CE47 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0CE47* InterPro IPR000795 http://www.ebi.ac.uk/interpro/entry/IPR000795 InterPro IPR004160 http://www.ebi.ac.uk/interpro/entry/IPR004160 InterPro IPR004161 http://www.ebi.ac.uk/interpro/entry/IPR004161 InterPro IPR004541 http://www.ebi.ac.uk/interpro/entry/IPR004541 InterPro IPR005225 http://www.ebi.ac.uk/interpro/entry/IPR005225 InterPro IPR009000 http://www.ebi.ac.uk/interpro/entry/IPR009000 InterPro IPR009001 http://www.ebi.ac.uk/interpro/entry/IPR009001 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR031157 http://www.ebi.ac.uk/interpro/entry/IPR031157 InterPro IPR033720 http://www.ebi.ac.uk/interpro/entry/IPR033720 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko03012 http://www.genome.jp/dbget-bin/www_bget?ko03012 KEGG_Gene ecj:JW3301 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3301 KEGG_Gene eco:b3339 http://www.genome.jp/dbget-bin/www_bget?eco:b3339 KEGG_Orthology KO:K02358 http://www.genome.jp/dbget-bin/www_bget?KO:K02358 KEGG_Pathway ko04626 http://www.genome.jp/kegg-bin/show_pathway?ko04626 PDB 1D8T http://www.ebi.ac.uk/pdbe-srv/view/entry/1D8T PDB 1EFC http://www.ebi.ac.uk/pdbe-srv/view/entry/1EFC PDB 1ETU http://www.ebi.ac.uk/pdbe-srv/view/entry/1ETU PDB 1MJ1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1MJ1 PDB 2FX3 http://www.ebi.ac.uk/pdbe-srv/view/entry/2FX3 PDB 2HCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/2HCJ PDB 2HDN http://www.ebi.ac.uk/pdbe-srv/view/entry/2HDN PDB 3EP2 http://www.ebi.ac.uk/pdbe-srv/view/entry/3EP2 PDB 3EQ3 http://www.ebi.ac.uk/pdbe-srv/view/entry/3EQ3 PDB 3EQ4 http://www.ebi.ac.uk/pdbe-srv/view/entry/3EQ4 PDB 3U2Q http://www.ebi.ac.uk/pdbe-srv/view/entry/3U2Q PDB 3U6B http://www.ebi.ac.uk/pdbe-srv/view/entry/3U6B PDB 3U6K http://www.ebi.ac.uk/pdbe-srv/view/entry/3U6K PDB 4G5G http://www.ebi.ac.uk/pdbe-srv/view/entry/4G5G PDB 4PC3 http://www.ebi.ac.uk/pdbe-srv/view/entry/4PC3 PDB 4PC7 http://www.ebi.ac.uk/pdbe-srv/view/entry/4PC7 PDB 4Q7J http://www.ebi.ac.uk/pdbe-srv/view/entry/4Q7J PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 5JBQ http://www.ebi.ac.uk/pdbe-srv/view/entry/5JBQ PDBsum 1D8T http://www.ebi.ac.uk/pdbsum/1D8T PDBsum 1EFC http://www.ebi.ac.uk/pdbsum/1EFC PDBsum 1ETU http://www.ebi.ac.uk/pdbsum/1ETU PDBsum 1MJ1 http://www.ebi.ac.uk/pdbsum/1MJ1 PDBsum 2FX3 http://www.ebi.ac.uk/pdbsum/2FX3 PDBsum 2HCJ http://www.ebi.ac.uk/pdbsum/2HCJ PDBsum 2HDN http://www.ebi.ac.uk/pdbsum/2HDN PDBsum 3EP2 http://www.ebi.ac.uk/pdbsum/3EP2 PDBsum 3EQ3 http://www.ebi.ac.uk/pdbsum/3EQ3 PDBsum 3EQ4 http://www.ebi.ac.uk/pdbsum/3EQ4 PDBsum 3U2Q http://www.ebi.ac.uk/pdbsum/3U2Q PDBsum 3U6B http://www.ebi.ac.uk/pdbsum/3U6B PDBsum 3U6K http://www.ebi.ac.uk/pdbsum/3U6K PDBsum 4G5G http://www.ebi.ac.uk/pdbsum/4G5G PDBsum 4PC3 http://www.ebi.ac.uk/pdbsum/4PC3 PDBsum 4PC7 http://www.ebi.ac.uk/pdbsum/4PC7 PDBsum 4Q7J http://www.ebi.ac.uk/pdbsum/4Q7J PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 5JBQ http://www.ebi.ac.uk/pdbsum/5JBQ PRINTS PR00315 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00315 PROSITE PS00301 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00301 PROSITE PS51722 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51722 PSORT swissprot:EFTU1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EFTU1_ECOLI PSORT-B swissprot:EFTU1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EFTU1_ECOLI PSORT2 swissprot:EFTU1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EFTU1_ECOLI Pfam PF03143 http://pfam.xfam.org/family/PF03143 Pfam PF03144 http://pfam.xfam.org/family/PF03144 Phobius swissprot:EFTU1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EFTU1_ECOLI PhylomeDB P0CE47 http://phylomedb.org/?seqid=P0CE47 ProteinModelPortal P0CE47 http://www.proteinmodelportal.org/query/uniprot/P0CE47 PubMed 10625477 http://www.ncbi.nlm.nih.gov/pubmed/10625477 PubMed 15069072 http://www.ncbi.nlm.nih.gov/pubmed/15069072 PubMed 16552145 http://www.ncbi.nlm.nih.gov/pubmed/16552145 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17057344 http://www.ncbi.nlm.nih.gov/pubmed/17057344 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 19150849 http://www.ncbi.nlm.nih.gov/pubmed/19150849 PubMed 2022614 http://www.ncbi.nlm.nih.gov/pubmed/2022614 PubMed 2157708 http://www.ncbi.nlm.nih.gov/pubmed/2157708 PubMed 24095282 http://www.ncbi.nlm.nih.gov/pubmed/24095282 PubMed 24141193 http://www.ncbi.nlm.nih.gov/pubmed/24141193 PubMed 2498311 http://www.ncbi.nlm.nih.gov/pubmed/2498311 PubMed 2508560 http://www.ncbi.nlm.nih.gov/pubmed/2508560 PubMed 2684669 http://www.ncbi.nlm.nih.gov/pubmed/2684669 PubMed 3308869 http://www.ncbi.nlm.nih.gov/pubmed/3308869 PubMed 389663 http://www.ncbi.nlm.nih.gov/pubmed/389663 PubMed 3908095 http://www.ncbi.nlm.nih.gov/pubmed/3908095 PubMed 6997043 http://www.ncbi.nlm.nih.gov/pubmed/6997043 PubMed 7011903 http://www.ncbi.nlm.nih.gov/pubmed/7011903 PubMed 7021545 http://www.ncbi.nlm.nih.gov/pubmed/7021545 PubMed 7525272 http://www.ncbi.nlm.nih.gov/pubmed/7525272 PubMed 775340 http://www.ncbi.nlm.nih.gov/pubmed/775340 PubMed 7957075 http://www.ncbi.nlm.nih.gov/pubmed/7957075 PubMed 816798 http://www.ncbi.nlm.nih.gov/pubmed/816798 PubMed 8416965 http://www.ncbi.nlm.nih.gov/pubmed/8416965 PubMed 8978702 http://www.ncbi.nlm.nih.gov/pubmed/8978702 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9468511 http://www.ncbi.nlm.nih.gov/pubmed/9468511 PubMed 9918724 http://www.ncbi.nlm.nih.gov/pubmed/9918724 RefSeq NP_417798 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417798 RefSeq WP_000031783 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000031783 SMR P0CE47 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0CE47 STRING 511145.b3339 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3339&targetmode=cogs STRING COG0050 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0050&targetmode=cogs SUPFAM SSF50447 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50447 SUPFAM SSF50465 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50465 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR00231 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00231 TIGRFAMs TIGR00485 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00485 UniProtKB EFTU1_ECOLI http://www.uniprot.org/uniprot/EFTU1_ECOLI UniProtKB-AC P0CE47 http://www.uniprot.org/uniprot/P0CE47 charge swissprot:EFTU1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EFTU1_ECOLI eggNOG COG0050 http://eggnogapi.embl.de/nog_data/html/tree/COG0050 eggNOG ENOG4105CGV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CGV epestfind swissprot:EFTU1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EFTU1_ECOLI garnier swissprot:EFTU1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EFTU1_ECOLI helixturnhelix swissprot:EFTU1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EFTU1_ECOLI hmoment swissprot:EFTU1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EFTU1_ECOLI iep swissprot:EFTU1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EFTU1_ECOLI inforesidue swissprot:EFTU1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EFTU1_ECOLI octanol swissprot:EFTU1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EFTU1_ECOLI pepcoil swissprot:EFTU1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EFTU1_ECOLI pepdigest swissprot:EFTU1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EFTU1_ECOLI pepinfo swissprot:EFTU1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EFTU1_ECOLI pepnet swissprot:EFTU1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EFTU1_ECOLI pepstats swissprot:EFTU1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EFTU1_ECOLI pepwheel swissprot:EFTU1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EFTU1_ECOLI pepwindow swissprot:EFTU1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EFTU1_ECOLI sigcleave swissprot:EFTU1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EFTU1_ECOLI ## Database ID URL or Descriptions # AltName GALU_ECOLI Alpha-D-glucosyl-1-phosphate uridylyltransferase # AltName GALU_ECOLI UDP-glucose pyrophosphorylase # AltName GALU_ECOLI Uridine diphosphoglucose pyrophosphorylase # BRENDA 2.7.7 2026 # BioGrid 4260121 436 # CATALYTIC ACTIVITY GALU_ECOLI UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose. # COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI 18420; # EcoGene EG11319 galU # FUNCTION GALU_ECOLI May play a role in stationary phase survival. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GALU_ECOLI GO 0003983 UTP glucose-1-phosphate uridylyltransferase activity; IDA EcoCyc. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_process GO:0006011 UDP-glucose metabolic process; IMP:EcoCyc. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IMP:EcoCyc. # GO_process GO:0009242 colanic acid biosynthetic process; IMP:EcoCyc. # GO_process GO:0033499 galactose catabolic process via UDP-galactose; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.90.550.10 -; 1. # IntAct P0AEP3 3 # InterPro IPR005771 GalU_uridylyltTrfase_bac/arc # InterPro IPR005835 NTP_transferase_dom # InterPro IPR029044 Nucleotide-diphossugar_trans # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00040 Pentose and glucuronate interconversions # KEGG_Pathway ko00052 Galactose metabolism # KEGG_Pathway ko00500 Starch and sucrose metabolism # KEGG_Pathway ko00520 Amino sugar and nucleotide sugar metabolism # Organism GALU_ECOLI Escherichia coli (strain K12) # PATRIC 32117728 VBIEscCol129921_1284 # PDB 2E3D X-ray; 1.95 A; A/B/C/D=1-302 # PIR G64870 JC2265 # Pfam PF00483 NTP_transferase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GALU_ECOLI UTP--glucose-1-phosphate uridylyltransferase # RefSeq NP_415752 NC_000913.3 # RefSeq WP_000718995 NZ_LN832404.1 # SIMILARITY Belongs to the UDPGP type 2 family. {ECO 0000305}. # SUBUNIT GALU_ECOLI Homotetramer or homopentamer. # SUPFAM SSF53448 SSF53448 # TIGRFAMs TIGR01099 galU # eggNOG COG1210 LUCA # eggNOG ENOG4105C3Y Bacteria BLAST swissprot:GALU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GALU_ECOLI BioCyc ECOL316407:JW1224-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1224-MONOMER BioCyc EcoCyc:GLUC1PURIDYLTRANS-MONOMER http://biocyc.org/getid?id=EcoCyc:GLUC1PURIDYLTRANS-MONOMER BioCyc MetaCyc:GLUC1PURIDYLTRANS-MONOMER http://biocyc.org/getid?id=MetaCyc:GLUC1PURIDYLTRANS-MONOMER COG COG1210 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1210 DIP DIP-35950N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35950N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.7.9 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.9 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M98830 http://www.ebi.ac.uk/ena/data/view/M98830 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X59940 http://www.ebi.ac.uk/ena/data/view/X59940 ENZYME 2.7.7.9 http://enzyme.expasy.org/EC/2.7.7.9 EchoBASE EB1295 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1295 EcoGene EG11319 http://www.ecogene.org/geneInfo.php?eg_id=EG11319 EnsemblBacteria AAC74318 http://www.ensemblgenomes.org/id/AAC74318 EnsemblBacteria AAC74318 http://www.ensemblgenomes.org/id/AAC74318 EnsemblBacteria BAA36104 http://www.ensemblgenomes.org/id/BAA36104 EnsemblBacteria BAA36104 http://www.ensemblgenomes.org/id/BAA36104 EnsemblBacteria BAA36104 http://www.ensemblgenomes.org/id/BAA36104 EnsemblBacteria b1236 http://www.ensemblgenomes.org/id/b1236 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0003983 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003983 GO_process GO:0006011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006011 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GO_process GO:0009242 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009242 GO_process GO:0033499 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033499 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.90.550.10 http://www.cathdb.info/version/latest/superfamily/3.90.550.10 GeneID 945730 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945730 HOGENOM HOG000283477 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000283477&db=HOGENOM6 InParanoid P0AEP3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEP3 IntAct P0AEP3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEP3* IntEnz 2.7.7.9 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.9 InterPro IPR005771 http://www.ebi.ac.uk/interpro/entry/IPR005771 InterPro IPR005835 http://www.ebi.ac.uk/interpro/entry/IPR005835 InterPro IPR029044 http://www.ebi.ac.uk/interpro/entry/IPR029044 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1224 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1224 KEGG_Gene eco:b1236 http://www.genome.jp/dbget-bin/www_bget?eco:b1236 KEGG_Orthology KO:K00963 http://www.genome.jp/dbget-bin/www_bget?KO:K00963 KEGG_Pathway ko00040 http://www.genome.jp/kegg-bin/show_pathway?ko00040 KEGG_Pathway ko00052 http://www.genome.jp/kegg-bin/show_pathway?ko00052 KEGG_Pathway ko00500 http://www.genome.jp/kegg-bin/show_pathway?ko00500 KEGG_Pathway ko00520 http://www.genome.jp/kegg-bin/show_pathway?ko00520 KEGG_Reaction rn:R00289 http://www.genome.jp/dbget-bin/www_bget?rn:R00289 OMA IGYMQAF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IGYMQAF PDB 2E3D http://www.ebi.ac.uk/pdbe-srv/view/entry/2E3D PDBsum 2E3D http://www.ebi.ac.uk/pdbsum/2E3D PSORT swissprot:GALU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GALU_ECOLI PSORT-B swissprot:GALU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GALU_ECOLI PSORT2 swissprot:GALU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GALU_ECOLI Pfam PF00483 http://pfam.xfam.org/family/PF00483 Phobius swissprot:GALU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GALU_ECOLI PhylomeDB P0AEP3 http://phylomedb.org/?seqid=P0AEP3 ProteinModelPortal P0AEP3 http://www.proteinmodelportal.org/query/uniprot/P0AEP3 PubMed 1537791 http://www.ncbi.nlm.nih.gov/pubmed/1537791 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7961613 http://www.ncbi.nlm.nih.gov/pubmed/7961613 PubMed 8169209 http://www.ncbi.nlm.nih.gov/pubmed/8169209 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_415752 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415752 RefSeq WP_000718995 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000718995 SMR P0AEP3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEP3 STRING 511145.b1236 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1236&targetmode=cogs STRING COG1210 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1210&targetmode=cogs SUPFAM SSF53448 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53448 TIGRFAMs TIGR01099 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01099 UniProtKB GALU_ECOLI http://www.uniprot.org/uniprot/GALU_ECOLI UniProtKB-AC P0AEP3 http://www.uniprot.org/uniprot/P0AEP3 charge swissprot:GALU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GALU_ECOLI eggNOG COG1210 http://eggnogapi.embl.de/nog_data/html/tree/COG1210 eggNOG ENOG4105C3Y http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C3Y epestfind swissprot:GALU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GALU_ECOLI garnier swissprot:GALU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GALU_ECOLI helixturnhelix swissprot:GALU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GALU_ECOLI hmoment swissprot:GALU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GALU_ECOLI iep swissprot:GALU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GALU_ECOLI inforesidue swissprot:GALU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GALU_ECOLI octanol swissprot:GALU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GALU_ECOLI pepcoil swissprot:GALU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GALU_ECOLI pepdigest swissprot:GALU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GALU_ECOLI pepinfo swissprot:GALU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GALU_ECOLI pepnet swissprot:GALU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GALU_ECOLI pepstats swissprot:GALU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GALU_ECOLI pepwheel swissprot:GALU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GALU_ECOLI pepwindow swissprot:GALU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GALU_ECOLI sigcleave swissprot:GALU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GALU_ECOLI ## Database ID URL or Descriptions # BioGrid 4263167 6 # EcoGene EG12834 yhdW # FUNCTION YHDW_ECOLI Probably part of the binding-protein-dependent transport system YdhWXYZ for an amino acid. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_function GO:0005215 transporter activity; IEA:InterPro. # GO_process GO:0006865 amino acid transport; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006810 transport # InterPro IPR001638 Solute-binding_3/MltF_N # InterPro IPR018313 SBP_3_CS # Organism YHDW_ECOLI Escherichia coli (strain K12) # PATRIC 48665997 VBIEscCol107702_3301 # PIR F65119 F65119 # PROSITE PS01039 SBP_BACTERIAL_3 # Pfam PF00497 SBP_bac_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHDW_ECOLI Putative amino-acid ABC transporter-binding protein YhdW # SEQUENCE CAUTION Sequence=AAA58072.1; Type=Frameshift; Positions=23; Evidence={ECO:0000305}; Sequence=U00096; Type=Frameshift; Positions=23; Evidence={ECO 0000305}; # SIMILARITY Belongs to the bacterial solute-binding protein 3 family. {ECO 0000305}. # SMART SM00062 PBPb # SUBCELLULAR LOCATION YHDW_ECOLI Periplasm {ECO 0000305}. # TCDB 3.A.1.3.26 the atp-binding cassette (abc) superfamily BLAST swissprot:YHDW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHDW_ECOLI BioCyc ECOL316407:JW3236-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3236-MONOMER BioCyc EcoCyc:YHDW-MONOMER http://biocyc.org/getid?id=EcoCyc:YHDW-MONOMER DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2683 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2683 EcoGene EG12834 http://www.ecogene.org/geneInfo.php?eg_id=EG12834 EnsemblBacteria BAE77309 http://www.ensemblgenomes.org/id/BAE77309 EnsemblBacteria BAE77309 http://www.ensemblgenomes.org/id/BAE77309 EnsemblBacteria BAE77309 http://www.ensemblgenomes.org/id/BAE77309 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_process GO:0006865 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 HOGENOM HOG000003595 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000003595&db=HOGENOM6 InParanoid P45766 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45766 IntAct P45766 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45766* InterPro IPR001638 http://www.ebi.ac.uk/interpro/entry/IPR001638 InterPro IPR018313 http://www.ebi.ac.uk/interpro/entry/IPR018313 KEGG_Gene ecj:JW3236 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3236 OMA DGQGLMV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DGQGLMV PROSITE PS01039 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01039 PSORT swissprot:YHDW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHDW_ECOLI PSORT-B swissprot:YHDW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHDW_ECOLI PSORT2 swissprot:YHDW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHDW_ECOLI Pfam PF00497 http://pfam.xfam.org/family/PF00497 Phobius swissprot:YHDW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHDW_ECOLI PhylomeDB P45766 http://phylomedb.org/?seqid=P45766 ProteinModelPortal P45766 http://www.proteinmodelportal.org/query/uniprot/P45766 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SMART SM00062 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00062 STRING 316407.85676059 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85676059&targetmode=cogs TCDB 3.A.1.3.26 http://www.tcdb.org/search/result.php?tc=3.A.1.3.26 UniProtKB YHDW_ECOLI http://www.uniprot.org/uniprot/YHDW_ECOLI UniProtKB-AC P45766 http://www.uniprot.org/uniprot/P45766 charge swissprot:YHDW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHDW_ECOLI epestfind swissprot:YHDW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHDW_ECOLI garnier swissprot:YHDW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHDW_ECOLI helixturnhelix swissprot:YHDW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHDW_ECOLI hmoment swissprot:YHDW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHDW_ECOLI iep swissprot:YHDW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHDW_ECOLI inforesidue swissprot:YHDW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHDW_ECOLI octanol swissprot:YHDW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHDW_ECOLI pepcoil swissprot:YHDW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHDW_ECOLI pepdigest swissprot:YHDW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHDW_ECOLI pepinfo swissprot:YHDW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHDW_ECOLI pepnet swissprot:YHDW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHDW_ECOLI pepstats swissprot:YHDW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHDW_ECOLI pepwheel swissprot:YHDW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHDW_ECOLI pepwindow swissprot:YHDW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHDW_ECOLI sigcleave swissprot:YHDW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHDW_ECOLI ## Database ID URL or Descriptions # EcoGene EG40006 insF3 # FUNCTION INSF3_ECOLI Involved in the transposition of the insertion sequence IS3. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006310 DNA recombination; IEA:UniProtKB-KW. # GO_process GO:0015074 DNA integration; IEA:InterPro. # GO_process GO:0032196 transposition; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 3.30.420.10 -; 1. # InterPro IPR001584 Integrase_cat-core # InterPro IPR012337 RNaseH-like_dom # InterPro IPR025948 HTH-like_dom # Organism INSF3_ECOLI Escherichia coli (strain K12) # PIR C64756 TQECI3 # PROSITE PS50994 INTEGRASE # Pfam PF00665 rve # Pfam PF13276 HTH_21 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSF3_ECOLI Transposase InsF for insertion sequence IS3C # RefSeq NP_061381 NC_002483.1 # RefSeq NP_414833 NC_000913.3 # RefSeq NP_414906 NC_000913.3 # RefSeq NP_415073 NC_000913.3 # RefSeq NP_415545 NC_000913.3 # RefSeq NP_416593 NC_000913.3 # RefSeq WP_000878218 NZ_LN832404.1 # SIMILARITY Belongs to the transposase IS3/IS150/IS904 family. {ECO 0000305}. # SIMILARITY Contains 1 integrase catalytic domain. {ECO:0000255|PROSITE-ProRule PRU00457}. # SUPFAM SSF53098 SSF53098 # eggNOG COG2801 LUCA BLAST swissprot:INSF3_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSF3_ECOLI DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB4716 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4716 EcoGene EG40006 http://www.ecogene.org/geneInfo.php?eg_id=EG40006 EnsemblBacteria AAC73642 http://www.ensemblgenomes.org/id/AAC73642 EnsemblBacteria AAC73642 http://www.ensemblgenomes.org/id/AAC73642 EnsemblBacteria BAE76316 http://www.ensemblgenomes.org/id/BAE76316 EnsemblBacteria BAE76316 http://www.ensemblgenomes.org/id/BAE76316 EnsemblBacteria BAE76316 http://www.ensemblgenomes.org/id/BAE76316 EnsemblBacteria b0541 http://www.ensemblgenomes.org/id/b0541 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0015074 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015074 GO_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 3.30.420.10 http://www.cathdb.info/version/latest/superfamily/3.30.420.10 GeneID 1263587 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263587 GeneID 944948 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944948 GeneID 945036 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945036 GeneID 945587 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945587 GeneID 946629 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946629 GeneID 947988 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947988 InParanoid P0CF81 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CF81 InterPro IPR001584 http://www.ebi.ac.uk/interpro/entry/IPR001584 InterPro IPR012337 http://www.ebi.ac.uk/interpro/entry/IPR012337 InterPro IPR025948 http://www.ebi.ac.uk/interpro/entry/IPR025948 KEGG_Gene ecj:JW0529 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0529 KEGG_Gene eco:b0299 http://www.genome.jp/dbget-bin/www_bget?eco:b0299 KEGG_Gene eco:b0372 http://www.genome.jp/dbget-bin/www_bget?eco:b0372 KEGG_Gene eco:b0541 http://www.genome.jp/dbget-bin/www_bget?eco:b0541 KEGG_Gene eco:b1026 http://www.genome.jp/dbget-bin/www_bget?eco:b1026 KEGG_Gene eco:b2089 http://www.genome.jp/dbget-bin/www_bget?eco:b2089 PROSITE PS50994 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50994 PSORT swissprot:INSF3_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSF3_ECOLI PSORT-B swissprot:INSF3_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSF3_ECOLI PSORT2 swissprot:INSF3_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSF3_ECOLI Pfam PF00665 http://pfam.xfam.org/family/PF00665 Pfam PF13276 http://pfam.xfam.org/family/PF13276 Phobius swissprot:INSF3_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSF3_ECOLI PhylomeDB P0CF81 http://phylomedb.org/?seqid=P0CF81 ProteinModelPortal P0CF81 http://www.proteinmodelportal.org/query/uniprot/P0CF81 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_061381 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061381 RefSeq NP_414833 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414833 RefSeq NP_414906 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414906 RefSeq NP_415073 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415073 RefSeq NP_415545 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415545 RefSeq NP_416593 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416593 RefSeq WP_000878218 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000878218 SMR P0CF81 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0CF81 STRING 511145.b2089 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2089&targetmode=cogs SUPFAM SSF53098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098 UniProtKB INSF3_ECOLI http://www.uniprot.org/uniprot/INSF3_ECOLI UniProtKB-AC P0CF81 http://www.uniprot.org/uniprot/P0CF81 charge swissprot:INSF3_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSF3_ECOLI eggNOG COG2801 http://eggnogapi.embl.de/nog_data/html/tree/COG2801 epestfind swissprot:INSF3_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSF3_ECOLI garnier swissprot:INSF3_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSF3_ECOLI helixturnhelix swissprot:INSF3_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSF3_ECOLI hmoment swissprot:INSF3_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSF3_ECOLI iep swissprot:INSF3_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSF3_ECOLI inforesidue swissprot:INSF3_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSF3_ECOLI octanol swissprot:INSF3_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSF3_ECOLI pepcoil swissprot:INSF3_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSF3_ECOLI pepdigest swissprot:INSF3_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSF3_ECOLI pepinfo swissprot:INSF3_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSF3_ECOLI pepnet swissprot:INSF3_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSF3_ECOLI pepstats swissprot:INSF3_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSF3_ECOLI pepwheel swissprot:INSF3_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSF3_ECOLI pepwindow swissprot:INSF3_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSF3_ECOLI sigcleave swissprot:INSF3_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSF3_ECOLI ## Database ID URL or Descriptions # EcoGene EG40005 insE2 # FUNCTION INSE2_ECOLI Involved in the transposition of the insertion sequence IS3. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 1.10.10.60 -; 1. # InterPro IPR002514 Transposase_8 # InterPro IPR009057 Homeodomain-like # Organism INSE2_ECOLI Escherichia coli (strain K12) # PIR A64845 A64845 # Pfam PF01527 HTH_Tnp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSE2_ECOLI Transposase InsE for insertion sequence IS3B # RefSeq NP_061380 NC_002483.1 # RefSeq NP_061395 NC_002483.1 # RefSeq NP_414832 NC_000913.3 # RefSeq NP_414907 NC_000913.3 # RefSeq NP_415072 NC_000913.3 # RefSeq NP_415546 NC_000913.3 # RefSeq NP_416592 NC_000913.3 # RefSeq WP_000169527 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18096.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAE76154.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the transposase 8 family. {ECO 0000305}. # SUPFAM SSF46689 SSF46689 # eggNOG COG2963 LUCA # eggNOG ENOG41090WB Bacteria BLAST swissprot:INSE2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSE2_ECOLI BioCyc EcoCyc:MONOMER0-4242 http://biocyc.org/getid?id=EcoCyc:MONOMER0-4242 COG COG2963 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2963 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB4318 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4318 EcoGene EG40005 http://www.ecogene.org/geneInfo.php?eg_id=EG40005 EnsemblBacteria AAC73476 http://www.ensemblgenomes.org/id/AAC73476 EnsemblBacteria AAC73476 http://www.ensemblgenomes.org/id/AAC73476 EnsemblBacteria BAE76154 http://www.ensemblgenomes.org/id/BAE76154 EnsemblBacteria BAE76154 http://www.ensemblgenomes.org/id/BAE76154 EnsemblBacteria BAE76154 http://www.ensemblgenomes.org/id/BAE76154 EnsemblBacteria b0373 http://www.ensemblgenomes.org/id/b0373 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 GeneID 1263530 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263530 GeneID 1263552 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263552 GeneID 944952 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944952 GeneID 945584 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945584 GeneID 945759 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945759 GeneID 946616 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946616 GeneID 946900 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946900 HOGENOM HOG000266649 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000266649&db=HOGENOM6 InterPro IPR002514 http://www.ebi.ac.uk/interpro/entry/IPR002514 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 KEGG_Gene ecj:JW5050 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5050 KEGG_Gene eco:b0298 http://www.genome.jp/dbget-bin/www_bget?eco:b0298 KEGG_Gene eco:b0373 http://www.genome.jp/dbget-bin/www_bget?eco:b0373 KEGG_Gene eco:b0540 http://www.genome.jp/dbget-bin/www_bget?eco:b0540 KEGG_Gene eco:b1027 http://www.genome.jp/dbget-bin/www_bget?eco:b1027 KEGG_Gene eco:b2088 http://www.genome.jp/dbget-bin/www_bget?eco:b2088 KEGG_Orthology KO:K07483 http://www.genome.jp/dbget-bin/www_bget?KO:K07483 PSORT swissprot:INSE2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSE2_ECOLI PSORT-B swissprot:INSE2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSE2_ECOLI PSORT2 swissprot:INSE2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSE2_ECOLI Pfam PF01527 http://pfam.xfam.org/family/PF01527 Phobius swissprot:INSE2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSE2_ECOLI ProteinModelPortal P0CF67 http://www.proteinmodelportal.org/query/uniprot/P0CF67 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_061380 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061380 RefSeq NP_061395 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061395 RefSeq NP_414832 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414832 RefSeq NP_414907 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414907 RefSeq NP_415072 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415072 RefSeq NP_415546 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415546 RefSeq NP_416592 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416592 RefSeq WP_000169527 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000169527 STRING 511145.b2088 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2088&targetmode=cogs STRING COG2963 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2963&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 UniProtKB INSE2_ECOLI http://www.uniprot.org/uniprot/INSE2_ECOLI UniProtKB-AC P0CF67 http://www.uniprot.org/uniprot/P0CF67 charge swissprot:INSE2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSE2_ECOLI eggNOG COG2963 http://eggnogapi.embl.de/nog_data/html/tree/COG2963 eggNOG ENOG41090WB http://eggnogapi.embl.de/nog_data/html/tree/ENOG41090WB epestfind swissprot:INSE2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSE2_ECOLI garnier swissprot:INSE2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSE2_ECOLI helixturnhelix swissprot:INSE2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSE2_ECOLI hmoment swissprot:INSE2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSE2_ECOLI iep swissprot:INSE2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSE2_ECOLI inforesidue swissprot:INSE2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSE2_ECOLI octanol swissprot:INSE2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSE2_ECOLI pepcoil swissprot:INSE2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSE2_ECOLI pepdigest swissprot:INSE2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSE2_ECOLI pepinfo swissprot:INSE2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSE2_ECOLI pepnet swissprot:INSE2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSE2_ECOLI pepstats swissprot:INSE2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSE2_ECOLI pepwheel swissprot:INSE2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSE2_ECOLI pepwindow swissprot:INSE2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSE2_ECOLI sigcleave swissprot:INSE2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSE2_ECOLI ## Database ID URL or Descriptions # BioGrid 4263337 11 # CATALYTIC ACTIVITY NARV_ECOLI Nitrite + acceptor = nitrate + reduced acceptor. # COFACTOR NARV_ECOLI Name=heme; Xref=ChEBI CHEBI 30413; Evidence={ECO 0000250}; Note=Binds 2 heme groups per subunit. Heme 1 is located at the cytoplasmic interface, heme 2 is located at the periplasmic interface. Electrons are transferred from the periplasmic to the cytoplasmic heme. {ECO 0000250}; # EcoGene EG10644 narV # FUNCTION NARV_ECOLI This is a second nitrate reductase enzyme which can substitute for the NRA enzyme and allows E.coli to use nitrate as an electron acceptor during anaerobic growth. The gamma chain is a membrane-embedded heme-iron unit resembling cytochrome b, which transfers electrons from quinones to the beta subunit. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0009325 nitrate reductase complex; IEA:InterPro. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0008940 nitrate reductase activity; IDA:EcoCyc. # GO_function GO:0009055 electron carrier activity; IBA:GO_Central. # GO_function GO:0020037 heme binding; ISM:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0009061 anaerobic respiration; IDA:EcoCyc. # GO_process GO:0019645 anaerobic electron transport chain; IDA:EcoCyc. # GO_process GO:0042128 nitrate assimilation; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0071941 nitrogen cycle metabolic process # InterPro IPR003816 Nitrate_red_gam # InterPro IPR023234 NarG-like_domain # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00910 Nitrogen metabolism # Organism NARV_ECOLI Escherichia coli (strain K12) # PATRIC 32118222 VBIEscCol129921_1531 # PIR S11430 S11430 # Pfam PF02665 Nitrate_red_gam # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NARV_ECOLI Respiratory nitrate reductase 2 gamma chain # RefSeq NP_415982 NC_000913.3 # RefSeq WP_000617115 NZ_LN832404.1 # SUBCELLULAR LOCATION NARV_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT NARV_ECOLI Dimer of heterotrimers each composed of an alpha, a beta and a gamma chain. Alpha and beta are catalytic chains; gamma chains are involved in binding the enzyme complex to the cytoplasmic membrane. # SUPFAM SSF103501 SSF103501 # TCDB 5.A.3.1 the prokaryotic molybdopterin-containing oxidoreductase (pmo) family # TIGRFAMs TIGR00351 narI # eggNOG COG2181 LUCA # eggNOG ENOG4105D0D Bacteria BLAST swissprot:NARV_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NARV_ECOLI BioCyc ECOL316407:JW1460-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1460-MONOMER BioCyc EcoCyc:NARV-MONOMER http://biocyc.org/getid?id=EcoCyc:NARV-MONOMER BioCyc MetaCyc:NARV-MONOMER http://biocyc.org/getid?id=MetaCyc:NARV-MONOMER COG COG2181 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2181 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.7.99.4 http://www.genome.jp/dbget-bin/www_bget?EC:1.7.99.4 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X17110 http://www.ebi.ac.uk/ena/data/view/X17110 ENZYME 1.7.99.4 http://enzyme.expasy.org/EC/1.7.99.4 EchoBASE EB0638 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0638 EcoGene EG10644 http://www.ecogene.org/geneInfo.php?eg_id=EG10644 EnsemblBacteria AAC74547 http://www.ensemblgenomes.org/id/AAC74547 EnsemblBacteria AAC74547 http://www.ensemblgenomes.org/id/AAC74547 EnsemblBacteria BAA15102 http://www.ensemblgenomes.org/id/BAA15102 EnsemblBacteria BAA15102 http://www.ensemblgenomes.org/id/BAA15102 EnsemblBacteria BAA15102 http://www.ensemblgenomes.org/id/BAA15102 EnsemblBacteria b1465 http://www.ensemblgenomes.org/id/b1465 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0009325 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009325 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008940 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008940 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0020037 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0020037 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0009061 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009061 GO_process GO:0019645 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019645 GO_process GO:0042128 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042128 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0071941 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071941 GeneID 946029 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946029 HOGENOM HOG000237376 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000237376&db=HOGENOM6 InParanoid P0AF32 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AF32 IntEnz 1.7.99.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.7.99.4 InterPro IPR003816 http://www.ebi.ac.uk/interpro/entry/IPR003816 InterPro IPR023234 http://www.ebi.ac.uk/interpro/entry/IPR023234 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1460 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1460 KEGG_Gene eco:b1465 http://www.genome.jp/dbget-bin/www_bget?eco:b1465 KEGG_Orthology KO:K08347 http://www.genome.jp/dbget-bin/www_bget?KO:K08347 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Reaction rn:R00798 http://www.genome.jp/dbget-bin/www_bget?rn:R00798 KEGG_Reaction rn:R01106 http://www.genome.jp/dbget-bin/www_bget?rn:R01106 OMA VLFHVGV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VLFHVGV PSORT swissprot:NARV_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NARV_ECOLI PSORT-B swissprot:NARV_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NARV_ECOLI PSORT2 swissprot:NARV_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NARV_ECOLI Pfam PF02665 http://pfam.xfam.org/family/PF02665 Phobius swissprot:NARV_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NARV_ECOLI PhylomeDB P0AF32 http://phylomedb.org/?seqid=P0AF32 ProteinModelPortal P0AF32 http://www.proteinmodelportal.org/query/uniprot/P0AF32 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2233673 http://www.ncbi.nlm.nih.gov/pubmed/2233673 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415982 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415982 RefSeq WP_000617115 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000617115 SMR P0AF32 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AF32 STRING 511145.b1465 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1465&targetmode=cogs STRING COG2181 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2181&targetmode=cogs SUPFAM SSF103501 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103501 TCDB 5.A.3.1 http://www.tcdb.org/search/result.php?tc=5.A.3.1 TIGRFAMs TIGR00351 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00351 UniProtKB NARV_ECOLI http://www.uniprot.org/uniprot/NARV_ECOLI UniProtKB-AC P0AF32 http://www.uniprot.org/uniprot/P0AF32 charge swissprot:NARV_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NARV_ECOLI eggNOG COG2181 http://eggnogapi.embl.de/nog_data/html/tree/COG2181 eggNOG ENOG4105D0D http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D0D epestfind swissprot:NARV_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NARV_ECOLI garnier swissprot:NARV_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NARV_ECOLI helixturnhelix swissprot:NARV_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NARV_ECOLI hmoment swissprot:NARV_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NARV_ECOLI iep swissprot:NARV_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NARV_ECOLI inforesidue swissprot:NARV_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NARV_ECOLI octanol swissprot:NARV_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NARV_ECOLI pepcoil swissprot:NARV_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NARV_ECOLI pepdigest swissprot:NARV_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NARV_ECOLI pepinfo swissprot:NARV_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NARV_ECOLI pepnet swissprot:NARV_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NARV_ECOLI pepstats swissprot:NARV_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NARV_ECOLI pepwheel swissprot:NARV_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NARV_ECOLI pepwindow swissprot:NARV_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NARV_ECOLI sigcleave swissprot:NARV_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NARV_ECOLI ## Database ID URL or Descriptions # BioGrid 4260207 12 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG13782 yddK # Gene3D 3.80.10.10 -; 2. # InterPro IPR001611 Leu-rich_rpt # InterPro IPR032675 L_dom-like # Organism YDDK_ECOLI Escherichia coli (strain K12) # PATRIC 48662249 VBIEscCol107702_1486 # PIR B64900 B64900 # PROSITE PS51450 LRR; 8 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDDK_ECOLI Putative uncharacterized protein YddK # SIMILARITY Contains 9 LRR (leucine-rich) repeats. {ECO 0000305}. # SUPFAM SSF52058 SSF52058; 2 # eggNOG COG4886 LUCA # eggNOG ENOG4108UI3 Bacteria BLAST swissprot:YDDK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDDK_ECOLI BioCyc ECOL316407:JW1467-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1467-MONOMER BioCyc EcoCyc:G6772-MONOMER http://biocyc.org/getid?id=EcoCyc:G6772-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3544 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3544 EcoGene EG13782 http://www.ecogene.org/geneInfo.php?eg_id=EG13782 EnsemblBacteria BAE76450 http://www.ensemblgenomes.org/id/BAE76450 EnsemblBacteria BAE76450 http://www.ensemblgenomes.org/id/BAE76450 EnsemblBacteria BAE76450 http://www.ensemblgenomes.org/id/BAE76450 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.80.10.10 http://www.cathdb.info/version/latest/superfamily/3.80.10.10 HOGENOM HOG000009463 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009463&db=HOGENOM6 InParanoid P76123 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76123 InterPro IPR001611 http://www.ebi.ac.uk/interpro/entry/IPR001611 InterPro IPR032675 http://www.ebi.ac.uk/interpro/entry/IPR032675 KEGG_Gene ecj:JW1467 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1467 OMA FLTIMNN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FLTIMNN PROSITE PS51450 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51450 PSORT swissprot:YDDK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDDK_ECOLI PSORT-B swissprot:YDDK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDDK_ECOLI PSORT2 swissprot:YDDK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDDK_ECOLI Phobius swissprot:YDDK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDDK_ECOLI PhylomeDB P76123 http://phylomedb.org/?seqid=P76123 ProteinModelPortal P76123 http://www.proteinmodelportal.org/query/uniprot/P76123 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 STRING 316407.85674981 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85674981&targetmode=cogs SUPFAM SSF52058 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52058 UniProtKB YDDK_ECOLI http://www.uniprot.org/uniprot/YDDK_ECOLI UniProtKB-AC P76123 http://www.uniprot.org/uniprot/P76123 charge swissprot:YDDK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDDK_ECOLI eggNOG COG4886 http://eggnogapi.embl.de/nog_data/html/tree/COG4886 eggNOG ENOG4108UI3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UI3 epestfind swissprot:YDDK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDDK_ECOLI garnier swissprot:YDDK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDDK_ECOLI helixturnhelix swissprot:YDDK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDDK_ECOLI hmoment swissprot:YDDK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDDK_ECOLI iep swissprot:YDDK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDDK_ECOLI inforesidue swissprot:YDDK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDDK_ECOLI octanol swissprot:YDDK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDDK_ECOLI pepcoil swissprot:YDDK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDDK_ECOLI pepdigest swissprot:YDDK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDDK_ECOLI pepinfo swissprot:YDDK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDDK_ECOLI pepnet swissprot:YDDK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDDK_ECOLI pepstats swissprot:YDDK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDDK_ECOLI pepwheel swissprot:YDDK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDDK_ECOLI pepwindow swissprot:YDDK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDDK_ECOLI sigcleave swissprot:YDDK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDDK_ECOLI ## Database ID URL or Descriptions # AltName DLDH_ECOLI Dihydrolipoamide dehydrogenase # AltName DLDH_ECOLI E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes # AltName DLDH_ECOLI Glycine cleavage system L protein # BioGrid 4261370 34 # CATALYTIC ACTIVITY DLDH_ECOLI Protein N(6)-(dihydrolipoyl)lysine + NAD(+) = protein N(6)-(lipoyl)lysine + NADH. # COFACTOR DLDH_ECOLI Name=FAD; Xref=ChEBI CHEBI 57692; Evidence={ECO 0000250}; Note=Binds 1 FAD per subunit. {ECO 0000250}; # EcoGene EG10543 lpd # FUNCTION DLDH_ECOLI Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0004148 dihydrolipoyl dehydrogenase activity; IDA:EcoliWiki. # GO_function GO:0008270 zinc ion binding; IDA:EcoliWiki. # GO_function GO:0015036 disulfide oxidoreductase activity; IDA:EcoliWiki. # GO_function GO:0050660 flavin adenine dinucleotide binding; IDA:EcoliWiki. # GO_process GO:0006090 pyruvate metabolic process; IDA:EcoliWiki. # GO_process GO:0006096 glycolytic process; IEA:UniProtKB-KW. # GO_process GO:0006103 2-oxoglutarate metabolic process; IMP:EcoliWiki. # GO_process GO:0006979 response to oxidative stress; IMP:EcoCyc. # GO_process GO:0019464 glycine decarboxylation via glycine cleavage system; IMP:EcoCyc. # GO_process GO:0045454 cell redox homeostasis; IEA:InterPro. # GO_process GO:0055114 oxidation-reduction process; IDA:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0042592 homeostatic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.30.390.30 -; 1. # Gene3D 3.50.50.60 -; 3. # INTERACTION DLDH_ECOLI Self; NbExp=2; IntAct=EBI-542856, EBI-542856; P06959 aceF; NbExp=3; IntAct=EBI-542856, EBI-542707; P03018 uvrD; NbExp=2; IntAct=EBI-542856, EBI-559573; # IntAct P0A9P0 90 # InterPro IPR004099 Pyr_nucl-diS_OxRdtase_dimer # InterPro IPR006258 Lipoamide_DH # InterPro IPR012999 Pyr_OxRdtase_I_AS # InterPro IPR016156 FAD/NAD-linked_Rdtase_dimer # InterPro IPR023753 FAD/NAD-binding_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00010 Glycolysis / Gluconeogenesis # KEGG_Pathway ko00020 Citrate cycle (TCA cycle) # KEGG_Pathway ko00260 Glycine, serine and threonine metabolism # KEGG_Pathway ko00280 Valine, leucine and isoleucine degradation # KEGG_Pathway ko00620 Pyruvate metabolism # MISCELLANEOUS DLDH_ECOLI The active site is a redox-active disulfide bond. # Organism DLDH_ECOLI Escherichia coli (strain K12) # PATRIC 32115333 VBIEscCol129921_0118 # PDB 4JDR X-ray; 2.50 A; A/B=1-474 # PIR S45195 DEECLP # PROSITE PS00076 PYRIDINE_REDOX_1 # Pfam PF02852 Pyr_redox_dim # Pfam PF07992 Pyr_redox_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DLDH_ECOLI Dihydrolipoyl dehydrogenase # RefSeq NP_414658 NC_000913.3 # RefSeq WP_000102485 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA24742.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. {ECO 0000305}. # SUBCELLULAR LOCATION DLDH_ECOLI Cytoplasm {ECO 0000269|PubMed 16079137}. Cell inner membrane {ECO 0000269|PubMed 16079137}; Peripheral membrane protein {ECO 0000269|PubMed 16079137}. # SUBUNIT DLDH_ECOLI Homodimer. # SUPFAM SSF51905 SSF51905 # SUPFAM SSF55424 SSF55424 # TIGRFAMs TIGR01350 lipoamide_DH # eggNOG COG1249 LUCA # eggNOG ENOG4107QN2 Bacteria BLAST swissprot:DLDH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DLDH_ECOLI BioCyc ECOL316407:JW0112-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0112-MONOMER BioCyc EcoCyc:E3-MONOMER http://biocyc.org/getid?id=EcoCyc:E3-MONOMER BioCyc MetaCyc:E3-MONOMER http://biocyc.org/getid?id=MetaCyc:E3-MONOMER COG COG1249 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1249 DIP DIP-6854N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-6854N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1111/j.1432-1033.1983.tb07683.x http://dx.doi.org/10.1111/j.1432-1033.1983.tb07683.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.8.1.4 http://www.genome.jp/dbget-bin/www_bget?EC:1.8.1.4 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V01498 http://www.ebi.ac.uk/ena/data/view/V01498 ENZYME 1.8.1.4 http://enzyme.expasy.org/EC/1.8.1.4 EchoBASE EB0538 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0538 EcoGene EG10543 http://www.ecogene.org/geneInfo.php?eg_id=EG10543 EnsemblBacteria AAC73227 http://www.ensemblgenomes.org/id/AAC73227 EnsemblBacteria AAC73227 http://www.ensemblgenomes.org/id/AAC73227 EnsemblBacteria BAB96686 http://www.ensemblgenomes.org/id/BAB96686 EnsemblBacteria BAB96686 http://www.ensemblgenomes.org/id/BAB96686 EnsemblBacteria BAB96686 http://www.ensemblgenomes.org/id/BAB96686 EnsemblBacteria b0116 http://www.ensemblgenomes.org/id/b0116 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0004148 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004148 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0015036 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015036 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_process GO:0006090 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006090 GO_process GO:0006096 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006096 GO_process GO:0006103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006103 GO_process GO:0006979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979 GO_process GO:0019464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019464 GO_process GO:0045454 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045454 GO_process GO:0055114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.30.390.30 http://www.cathdb.info/version/latest/superfamily/3.30.390.30 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 GeneID 944854 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944854 HOGENOM HOG000276708 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276708&db=HOGENOM6 InParanoid P0A9P0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9P0 IntAct P0A9P0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9P0* IntEnz 1.8.1.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.8.1.4 InterPro IPR004099 http://www.ebi.ac.uk/interpro/entry/IPR004099 InterPro IPR006258 http://www.ebi.ac.uk/interpro/entry/IPR006258 InterPro IPR012999 http://www.ebi.ac.uk/interpro/entry/IPR012999 InterPro IPR016156 http://www.ebi.ac.uk/interpro/entry/IPR016156 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0112 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0112 KEGG_Gene eco:b0116 http://www.genome.jp/dbget-bin/www_bget?eco:b0116 KEGG_Orthology KO:K00382 http://www.genome.jp/dbget-bin/www_bget?KO:K00382 KEGG_Pathway ko00010 http://www.genome.jp/kegg-bin/show_pathway?ko00010 KEGG_Pathway ko00020 http://www.genome.jp/kegg-bin/show_pathway?ko00020 KEGG_Pathway ko00260 http://www.genome.jp/kegg-bin/show_pathway?ko00260 KEGG_Pathway ko00280 http://www.genome.jp/kegg-bin/show_pathway?ko00280 KEGG_Pathway ko00620 http://www.genome.jp/kegg-bin/show_pathway?ko00620 KEGG_Reaction rn:R01698 http://www.genome.jp/dbget-bin/www_bget?rn:R01698 KEGG_Reaction rn:R03815 http://www.genome.jp/dbget-bin/www_bget?rn:R03815 KEGG_Reaction rn:R07618 http://www.genome.jp/dbget-bin/www_bget?rn:R07618 MINT MINT-1242510 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1242510 OMA CSDGMTK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CSDGMTK PDB 4JDR http://www.ebi.ac.uk/pdbe-srv/view/entry/4JDR PDBsum 4JDR http://www.ebi.ac.uk/pdbsum/4JDR PROSITE PS00076 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00076 PSORT swissprot:DLDH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DLDH_ECOLI PSORT-B swissprot:DLDH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DLDH_ECOLI PSORT2 swissprot:DLDH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DLDH_ECOLI Pfam PF02852 http://pfam.xfam.org/family/PF02852 Pfam PF07992 http://pfam.xfam.org/family/PF07992 Phobius swissprot:DLDH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DLDH_ECOLI PhylomeDB P0A9P0 http://phylomedb.org/?seqid=P0A9P0 ProteinModelPortal P0A9P0 http://www.proteinmodelportal.org/query/uniprot/P0A9P0 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 2211531 http://www.ncbi.nlm.nih.gov/pubmed/2211531 PubMed 6352260 http://www.ncbi.nlm.nih.gov/pubmed/6352260 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_414658 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414658 RefSeq WP_000102485 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000102485 SMR P0A9P0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9P0 STRING 511145.b0116 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0116&targetmode=cogs STRING COG1249 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1249&targetmode=cogs SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 SUPFAM SSF55424 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55424 SWISS-2DPAGE P0A9P0 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A9P0 TIGRFAMs TIGR01350 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01350 UniProtKB DLDH_ECOLI http://www.uniprot.org/uniprot/DLDH_ECOLI UniProtKB-AC P0A9P0 http://www.uniprot.org/uniprot/P0A9P0 charge swissprot:DLDH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DLDH_ECOLI eggNOG COG1249 http://eggnogapi.embl.de/nog_data/html/tree/COG1249 eggNOG ENOG4107QN2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QN2 epestfind swissprot:DLDH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DLDH_ECOLI garnier swissprot:DLDH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DLDH_ECOLI helixturnhelix swissprot:DLDH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DLDH_ECOLI hmoment swissprot:DLDH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DLDH_ECOLI iep swissprot:DLDH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DLDH_ECOLI inforesidue swissprot:DLDH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DLDH_ECOLI octanol swissprot:DLDH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DLDH_ECOLI pepcoil swissprot:DLDH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DLDH_ECOLI pepdigest swissprot:DLDH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DLDH_ECOLI pepinfo swissprot:DLDH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DLDH_ECOLI pepnet swissprot:DLDH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DLDH_ECOLI pepstats swissprot:DLDH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DLDH_ECOLI pepwheel swissprot:DLDH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DLDH_ECOLI pepwindow swissprot:DLDH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DLDH_ECOLI sigcleave swissprot:DLDH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DLDH_ECOLI ## Database ID URL or Descriptions # BioGrid 4263163 200 # EcoGene EG12506 ytfF # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR000620 EamA_dom # Organism YTFF_ECOLI Escherichia coli (strain K12) # PATRIC 32123995 VBIEscCol129921_4342 # PIR S56435 S56435 # Pfam PF00892 EamA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YTFF_ECOLI Inner membrane protein YtfF # RefSeq NP_418631 NC_000913.3 # RefSeq WP_001350569 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97106.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAE78211.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Contains 1 EamA domain. {ECO 0000305}. # SUBCELLULAR LOCATION YTFF_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.7.3.19 the drug/metabolite transporter (dmt) superfamily # eggNOG ENOG4105DXC Bacteria # eggNOG ENOG410XR5C LUCA BLAST swissprot:YTFF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YTFF_ECOLI BioCyc ECOL316407:JW4168-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4168-MONOMER BioCyc EcoCyc:G7867-MONOMER http://biocyc.org/getid?id=EcoCyc:G7867-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2399 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2399 EcoGene EG12506 http://www.ecogene.org/geneInfo.php?eg_id=EG12506 EnsemblBacteria AAC77167 http://www.ensemblgenomes.org/id/AAC77167 EnsemblBacteria AAC77167 http://www.ensemblgenomes.org/id/AAC77167 EnsemblBacteria BAE78211 http://www.ensemblgenomes.org/id/BAE78211 EnsemblBacteria BAE78211 http://www.ensemblgenomes.org/id/BAE78211 EnsemblBacteria BAE78211 http://www.ensemblgenomes.org/id/BAE78211 EnsemblBacteria b4210 http://www.ensemblgenomes.org/id/b4210 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 948732 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948732 HOGENOM HOG000261708 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261708&db=HOGENOM6 InParanoid P39314 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39314 InterPro IPR000620 http://www.ebi.ac.uk/interpro/entry/IPR000620 KEGG_Gene ecj:JW4168 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4168 KEGG_Gene eco:b4210 http://www.genome.jp/dbget-bin/www_bget?eco:b4210 PSORT swissprot:YTFF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YTFF_ECOLI PSORT-B swissprot:YTFF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YTFF_ECOLI PSORT2 swissprot:YTFF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YTFF_ECOLI Pfam PF00892 http://pfam.xfam.org/family/PF00892 Phobius swissprot:YTFF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YTFF_ECOLI PhylomeDB P39314 http://phylomedb.org/?seqid=P39314 ProteinModelPortal P39314 http://www.proteinmodelportal.org/query/uniprot/P39314 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418631 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418631 RefSeq WP_001350569 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001350569 STRING 511145.b4210 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4210&targetmode=cogs TCDB 2.A.7.3.19 http://www.tcdb.org/search/result.php?tc=2.A.7.3.19 UniProtKB YTFF_ECOLI http://www.uniprot.org/uniprot/YTFF_ECOLI UniProtKB-AC P39314 http://www.uniprot.org/uniprot/P39314 charge swissprot:YTFF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YTFF_ECOLI eggNOG ENOG4105DXC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DXC eggNOG ENOG410XR5C http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XR5C epestfind swissprot:YTFF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YTFF_ECOLI garnier swissprot:YTFF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YTFF_ECOLI helixturnhelix swissprot:YTFF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YTFF_ECOLI hmoment swissprot:YTFF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YTFF_ECOLI iep swissprot:YTFF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YTFF_ECOLI inforesidue swissprot:YTFF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YTFF_ECOLI octanol swissprot:YTFF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YTFF_ECOLI pepcoil swissprot:YTFF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YTFF_ECOLI pepdigest swissprot:YTFF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YTFF_ECOLI pepinfo swissprot:YTFF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YTFF_ECOLI pepnet swissprot:YTFF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YTFF_ECOLI pepstats swissprot:YTFF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YTFF_ECOLI pepwheel swissprot:YTFF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YTFF_ECOLI pepwindow swissprot:YTFF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YTFF_ECOLI sigcleave swissprot:YTFF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YTFF_ECOLI ## Database ID URL or Descriptions # BioGrid 4260337 16 # CDD cd00207 fer2 # COFACTOR Name=FMN; Xref=ChEBI:CHEBI 58210; Evidence={ECO:0000250}; # EcoGene EG13510 yeaX # GO_function GO:0009055 electron carrier activity; IEA:InterPro. # GO_function GO:0016491 oxidoreductase activity; IBA:GO_Central. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051537 2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW. # GO_function GO:0071949 FAD binding; IBA:GO_Central. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # Gene3D 3.10.20.30 -; 1. # InterPro IPR000951 Ph_dOase_redase # InterPro IPR001041 2Fe-2S_ferredoxin-type # InterPro IPR001433 OxRdtase_FAD/NAD-bd # InterPro IPR006058 2Fe2S_fd_BS # InterPro IPR008333 OxRdtase_FAD-bd_dom # InterPro IPR012675 Beta-grasp_dom # InterPro IPR017927 Fd_Rdtase_FAD-bd # InterPro IPR017938 Riboflavin_synthase-like_b-brl # Organism YEAX_ECOLI Escherichia coli (strain K12) # PATRIC 32118923 VBIEscCol129921_1879 # PIR C64941 C64941 # PRINTS PR00409 PHDIOXRDTASE # PROSITE PS00197 2FE2S_FER_1 # PROSITE PS51085 2FE2S_FER_2 # PROSITE PS51384 FAD_FR # Pfam PF00111 Fer2 # Pfam PF00175 NAD_binding_1 # Pfam PF00970 FAD_binding_6 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEAX_ECOLI Putative dioxygenase subunit beta YeaX # RefSeq NP_416317 NC_000913.3 # RefSeq WP_001287026 NZ_LN832404.1 # SIMILARITY Belongs to the PDR/VanB family. {ECO 0000305}. # SIMILARITY Contains 1 2Fe-2S ferredoxin-type domain. {ECO:0000255|PROSITE-ProRule PRU00465}. # SIMILARITY Contains 1 FAD-binding FR-type domain. {ECO:0000255|PROSITE-ProRule PRU00716}. # SUBUNIT YEAX_ECOLI Probable heterodimer of YeaW and YeaX. # SUPFAM SSF54292 SSF54292 # SUPFAM SSF63380 SSF63380 # eggNOG COG1018 LUCA # eggNOG ENOG4105E3J Bacteria BLAST swissprot:YEAX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEAX_ECOLI BioCyc ECOL316407:JW1792-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1792-MONOMER BioCyc EcoCyc:G6989-MONOMER http://biocyc.org/getid?id=EcoCyc:G6989-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- EchoBASE EB3283 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3283 EcoGene EG13510 http://www.ecogene.org/geneInfo.php?eg_id=EG13510 EnsemblBacteria AAC74873 http://www.ensemblgenomes.org/id/AAC74873 EnsemblBacteria AAC74873 http://www.ensemblgenomes.org/id/AAC74873 EnsemblBacteria BAA15598 http://www.ensemblgenomes.org/id/BAA15598 EnsemblBacteria BAA15598 http://www.ensemblgenomes.org/id/BAA15598 EnsemblBacteria BAA15598 http://www.ensemblgenomes.org/id/BAA15598 EnsemblBacteria b1803 http://www.ensemblgenomes.org/id/b1803 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051537 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051537 GO_function GO:0071949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071949 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.10.20.30 http://www.cathdb.info/version/latest/superfamily/3.10.20.30 GeneID 946329 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946329 HOGENOM HOG000141052 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000141052&db=HOGENOM6 InParanoid P76254 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76254 IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR000951 http://www.ebi.ac.uk/interpro/entry/IPR000951 InterPro IPR001041 http://www.ebi.ac.uk/interpro/entry/IPR001041 InterPro IPR001433 http://www.ebi.ac.uk/interpro/entry/IPR001433 InterPro IPR006058 http://www.ebi.ac.uk/interpro/entry/IPR006058 InterPro IPR008333 http://www.ebi.ac.uk/interpro/entry/IPR008333 InterPro IPR012675 http://www.ebi.ac.uk/interpro/entry/IPR012675 InterPro IPR017927 http://www.ebi.ac.uk/interpro/entry/IPR017927 InterPro IPR017938 http://www.ebi.ac.uk/interpro/entry/IPR017938 KEGG_Gene ecj:JW1792 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1792 KEGG_Gene eco:b1803 http://www.genome.jp/dbget-bin/www_bget?eco:b1803 OMA SHILVQM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SHILVQM PRINTS PR00409 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00409 PROSITE PS00197 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00197 PROSITE PS51085 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51085 PROSITE PS51384 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51384 PSORT swissprot:YEAX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEAX_ECOLI PSORT-B swissprot:YEAX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEAX_ECOLI PSORT2 swissprot:YEAX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEAX_ECOLI Pfam PF00111 http://pfam.xfam.org/family/PF00111 Pfam PF00175 http://pfam.xfam.org/family/PF00175 Pfam PF00970 http://pfam.xfam.org/family/PF00970 Phobius swissprot:YEAX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEAX_ECOLI PhylomeDB P76254 http://phylomedb.org/?seqid=P76254 ProteinModelPortal P76254 http://www.proteinmodelportal.org/query/uniprot/P76254 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416317 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416317 RefSeq WP_001287026 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001287026 SMR P76254 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76254 STRING 511145.b1803 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1803&targetmode=cogs SUPFAM SSF54292 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54292 SUPFAM SSF63380 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63380 UniProtKB YEAX_ECOLI http://www.uniprot.org/uniprot/YEAX_ECOLI UniProtKB-AC P76254 http://www.uniprot.org/uniprot/P76254 charge swissprot:YEAX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEAX_ECOLI eggNOG COG1018 http://eggnogapi.embl.de/nog_data/html/tree/COG1018 eggNOG ENOG4105E3J http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E3J epestfind swissprot:YEAX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEAX_ECOLI garnier swissprot:YEAX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEAX_ECOLI helixturnhelix swissprot:YEAX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEAX_ECOLI hmoment swissprot:YEAX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEAX_ECOLI iep swissprot:YEAX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEAX_ECOLI inforesidue swissprot:YEAX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEAX_ECOLI octanol swissprot:YEAX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEAX_ECOLI pepcoil swissprot:YEAX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEAX_ECOLI pepdigest swissprot:YEAX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEAX_ECOLI pepinfo swissprot:YEAX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEAX_ECOLI pepnet swissprot:YEAX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEAX_ECOLI pepstats swissprot:YEAX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEAX_ECOLI pepwheel swissprot:YEAX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEAX_ECOLI pepwindow swissprot:YEAX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEAX_ECOLI sigcleave swissprot:YEAX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEAX_ECOLI ## Database ID URL or Descriptions # BioGrid 4260061 132 # COFACTOR YCDX_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 12661000}; Note=Binds 3 Zn(2+) ions per subunit. {ECO 0000269|PubMed 12661000}; # DISRUPTION PHENOTYPE Mutants show no swarming ability. {ECO:0000269|PubMed 21965574}. # ENZYME REGULATION Activity is stimulated by YcdY. {ECO:0000269|PubMed 21965574}. # EcoGene EG13870 ycdX # FUNCTION YCDX_ECOLI Hydrolyzes p-nitrophenyl phosphate (pNPP) in vitro. Involved in the swarming motility process. {ECO 0000269|PubMed 21965574}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_function GO:0003887 DNA-directed DNA polymerase activity; IEA:InterPro. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_function GO:0016791 phosphatase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0042578 phosphoric ester hydrolase activity; IDA:EcoCyc. # GO_process GO:0006260 DNA replication; IEA:InterPro. # GO_process GO:0071978 bacterial-type flagellum-dependent swarming motility; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0048870 cell motility # HAMAP MF_01561 YcdX_phosphat # INTERACTION YCDX_ECOLI P75915 ycdY; NbExp=2; IntAct=EBI-1121626, EBI-1121634; # IntAct P75914 8 # InterPro IPR003141 Pol/His_phosphatase_N # InterPro IPR004013 PHP_dom # InterPro IPR016195 Pol/histidinol_Pase-like # InterPro IPR023710 Phosphatase_YcdX_put # Organism YCDX_ECOLI Escherichia coli (strain K12) # PATRIC 32117299 VBIEscCol129921_1072 # PDB 1M65 X-ray; 1.57 A; A=1-245 # PDB 1M68 X-ray; 2.30 A; A=1-245 # PDB 1PB0 X-ray; 1.95 A; A/B/C=1-245 # PIR G64845 G64845 # Pfam PF02811 PHP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Probable phosphatase YcdX {ECO:0000255|HAMAP-Rule MF_01561} # RefSeq NP_415552 NC_000913.3 # RefSeq WP_000283667 NZ_LN832404.1 # SIMILARITY Belongs to the PHP family. {ECO:0000255|HAMAP- Rule MF_01561}. # SMART SM00481 POLIIIAc # SUBUNIT YCDX_ECOLI Homotrimer. Interacts with YcdY. {ECO 0000255|HAMAP- Rule MF_01561, ECO 0000269|PubMed 12661000, ECO 0000269|PubMed 21965574}. # SUPFAM SSF89550 SSF89550 # eggNOG COG1387 LUCA # eggNOG ENOG4107SSZ Bacteria BLAST swissprot:YCDX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCDX_ECOLI BioCyc ECOL316407:JW1017-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1017-MONOMER BioCyc EcoCyc:G6540-MONOMER http://biocyc.org/getid?id=EcoCyc:G6540-MONOMER COG COG1387 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1387 DOI 10.1002/prot.10352 http://dx.doi.org/10.1002/prot.10352 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.05927-11 http://dx.doi.org/10.1128/JB.05927-11 EC_number EC:3.1.3.- {ECO:0000255|HAMAP-Rule:MF_01561} http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.- {ECO:0000255|HAMAP-Rule:MF_01561} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.3.- {ECO:0000255|HAMAP-Rule:MF_01561} http://enzyme.expasy.org/EC/3.1.3.- {ECO:0000255|HAMAP-Rule:MF_01561} EchoBASE EB3629 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3629 EcoGene EG13870 http://www.ecogene.org/geneInfo.php?eg_id=EG13870 EnsemblBacteria AAC74118 http://www.ensemblgenomes.org/id/AAC74118 EnsemblBacteria AAC74118 http://www.ensemblgenomes.org/id/AAC74118 EnsemblBacteria BAA35815 http://www.ensemblgenomes.org/id/BAA35815 EnsemblBacteria BAA35815 http://www.ensemblgenomes.org/id/BAA35815 EnsemblBacteria BAA35815 http://www.ensemblgenomes.org/id/BAA35815 EnsemblBacteria b1034 http://www.ensemblgenomes.org/id/b1034 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003887 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GO_function GO:0042578 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042578 GO_process GO:0006260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260 GO_process GO:0071978 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071978 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 GeneID 948477 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948477 HAMAP MF_01561 http://hamap.expasy.org/unirule/MF_01561 HOGENOM HOG000218067 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218067&db=HOGENOM6 InParanoid P75914 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75914 IntAct P75914 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75914* IntEnz 3.1.3.- {ECO:0000255|HAMAP-Rule:MF_01561} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.- {ECO:0000255|HAMAP-Rule:MF_01561} InterPro IPR003141 http://www.ebi.ac.uk/interpro/entry/IPR003141 InterPro IPR004013 http://www.ebi.ac.uk/interpro/entry/IPR004013 InterPro IPR016195 http://www.ebi.ac.uk/interpro/entry/IPR016195 InterPro IPR023710 http://www.ebi.ac.uk/interpro/entry/IPR023710 KEGG_Gene ecj:JW1017 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1017 KEGG_Gene eco:b1034 http://www.genome.jp/dbget-bin/www_bget?eco:b1034 KEGG_Orthology KO:K04477 http://www.genome.jp/dbget-bin/www_bget?KO:K04477 OMA SEPNCRA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SEPNCRA PDB 1M65 http://www.ebi.ac.uk/pdbe-srv/view/entry/1M65 PDB 1M68 http://www.ebi.ac.uk/pdbe-srv/view/entry/1M68 PDB 1PB0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1PB0 PDBsum 1M65 http://www.ebi.ac.uk/pdbsum/1M65 PDBsum 1M68 http://www.ebi.ac.uk/pdbsum/1M68 PDBsum 1PB0 http://www.ebi.ac.uk/pdbsum/1PB0 PSORT swissprot:YCDX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCDX_ECOLI PSORT-B swissprot:YCDX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCDX_ECOLI PSORT2 swissprot:YCDX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCDX_ECOLI Pfam PF02811 http://pfam.xfam.org/family/PF02811 Phobius swissprot:YCDX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCDX_ECOLI PhylomeDB P75914 http://phylomedb.org/?seqid=P75914 ProteinModelPortal P75914 http://www.proteinmodelportal.org/query/uniprot/P75914 PubMed 12661000 http://www.ncbi.nlm.nih.gov/pubmed/12661000 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21965574 http://www.ncbi.nlm.nih.gov/pubmed/21965574 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415552 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415552 RefSeq WP_000283667 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000283667 SMART SM00481 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00481 SMR P75914 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75914 STRING 511145.b1034 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1034&targetmode=cogs STRING COG1387 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1387&targetmode=cogs SUPFAM SSF89550 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF89550 UniProtKB YCDX_ECOLI http://www.uniprot.org/uniprot/YCDX_ECOLI UniProtKB-AC P75914 http://www.uniprot.org/uniprot/P75914 charge swissprot:YCDX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCDX_ECOLI eggNOG COG1387 http://eggnogapi.embl.de/nog_data/html/tree/COG1387 eggNOG ENOG4107SSZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107SSZ epestfind swissprot:YCDX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCDX_ECOLI garnier swissprot:YCDX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCDX_ECOLI helixturnhelix swissprot:YCDX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCDX_ECOLI hmoment swissprot:YCDX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCDX_ECOLI iep swissprot:YCDX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCDX_ECOLI inforesidue swissprot:YCDX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCDX_ECOLI octanol swissprot:YCDX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCDX_ECOLI pepcoil swissprot:YCDX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCDX_ECOLI pepdigest swissprot:YCDX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCDX_ECOLI pepinfo swissprot:YCDX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCDX_ECOLI pepnet swissprot:YCDX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCDX_ECOLI pepstats swissprot:YCDX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCDX_ECOLI pepwheel swissprot:YCDX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCDX_ECOLI pepwindow swissprot:YCDX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCDX_ECOLI sigcleave swissprot:YCDX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCDX_ECOLI ## Database ID URL or Descriptions # BioGrid 4259531 20 # COFACTOR SPRT_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000305}; Note=Binds 1 zinc ion. {ECO 0000305}; # EcoGene EG12122 sprT # FUNCTION SPRT_ECOLI Involved in bolA gene expression at the stationary phase. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0008270 zinc ion binding; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0043167 ion binding # HAMAP MF_00746 SprT # IntAct P39902 7 # InterPro IPR006640 SprT-like_domain # InterPro IPR023483 Uncharacterised_SprT # Organism SPRT_ECOLI Escherichia coli (strain K12) # PATRIC 32121298 VBIEscCol129921_3037 # PIR G65079 G65079 # PROSITE PS00142 ZINC_PROTEASE # Pfam PF10263 SprT-like # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SPRT_ECOLI Protein SprT # RefSeq NP_417419 NC_000913.3 # RefSeq WP_001300769 NZ_LN832404.1 # SIMILARITY Belongs to the SprT family. {ECO 0000305}. # SIMILARITY Contains 1 SprT-like domain. {ECO 0000305}. # SMART SM00731 SprT # SUBCELLULAR LOCATION SPRT_ECOLI Cytoplasm {ECO 0000305}. # eggNOG COG3091 LUCA # eggNOG ENOG4105GPY Bacteria BLAST swissprot:SPRT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SPRT_ECOLI BioCyc ECOL316407:JW2911-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2911-MONOMER BioCyc EcoCyc:EG12122-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12122-MONOMER COG COG3091 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3091 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D83644 http://www.ebi.ac.uk/ena/data/view/D83644 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EMBL X65169 http://www.ebi.ac.uk/ena/data/view/X65169 EchoBASE EB2043 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2043 EcoGene EG12122 http://www.ecogene.org/geneInfo.php?eg_id=EG12122 EnsemblBacteria AAC75981 http://www.ensemblgenomes.org/id/AAC75981 EnsemblBacteria AAC75981 http://www.ensemblgenomes.org/id/AAC75981 EnsemblBacteria BAE77007 http://www.ensemblgenomes.org/id/BAE77007 EnsemblBacteria BAE77007 http://www.ensemblgenomes.org/id/BAE77007 EnsemblBacteria BAE77007 http://www.ensemblgenomes.org/id/BAE77007 EnsemblBacteria b2944 http://www.ensemblgenomes.org/id/b2944 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GeneID 947443 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947443 HAMAP MF_00746 http://hamap.expasy.org/unirule/MF_00746 HOGENOM HOG000281171 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000281171&db=HOGENOM6 InParanoid P39902 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39902 IntAct P39902 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39902* InterPro IPR006640 http://www.ebi.ac.uk/interpro/entry/IPR006640 InterPro IPR023483 http://www.ebi.ac.uk/interpro/entry/IPR023483 KEGG_Gene ecj:JW2911 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2911 KEGG_Gene eco:b2944 http://www.genome.jp/dbget-bin/www_bget?eco:b2944 KEGG_Orthology KO:K02742 http://www.genome.jp/dbget-bin/www_bget?KO:K02742 OMA QPHGEEW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QPHGEEW PROSITE PS00142 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00142 PSORT swissprot:SPRT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SPRT_ECOLI PSORT-B swissprot:SPRT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SPRT_ECOLI PSORT2 swissprot:SPRT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SPRT_ECOLI Pfam PF10263 http://pfam.xfam.org/family/PF10263 Phobius swissprot:SPRT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SPRT_ECOLI ProteinModelPortal P39902 http://www.proteinmodelportal.org/query/uniprot/P39902 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 8113204 http://www.ncbi.nlm.nih.gov/pubmed/8113204 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417419 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417419 RefSeq WP_001300769 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300769 SMART SM00731 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00731 STRING 511145.b2944 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2944&targetmode=cogs STRING COG3091 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3091&targetmode=cogs UniProtKB SPRT_ECOLI http://www.uniprot.org/uniprot/SPRT_ECOLI UniProtKB-AC P39902 http://www.uniprot.org/uniprot/P39902 charge swissprot:SPRT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SPRT_ECOLI eggNOG COG3091 http://eggnogapi.embl.de/nog_data/html/tree/COG3091 eggNOG ENOG4105GPY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105GPY epestfind swissprot:SPRT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SPRT_ECOLI garnier swissprot:SPRT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SPRT_ECOLI helixturnhelix swissprot:SPRT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SPRT_ECOLI hmoment swissprot:SPRT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SPRT_ECOLI iep swissprot:SPRT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SPRT_ECOLI inforesidue swissprot:SPRT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SPRT_ECOLI octanol swissprot:SPRT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SPRT_ECOLI pepcoil swissprot:SPRT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SPRT_ECOLI pepdigest swissprot:SPRT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SPRT_ECOLI pepinfo swissprot:SPRT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SPRT_ECOLI pepnet swissprot:SPRT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SPRT_ECOLI pepstats swissprot:SPRT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SPRT_ECOLI pepwheel swissprot:SPRT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SPRT_ECOLI pepwindow swissprot:SPRT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SPRT_ECOLI sigcleave swissprot:SPRT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SPRT_ECOLI ## Database ID URL or Descriptions # AltName CNU_ECOLI H-NS/StpA-binding protein 2 # AltName CNU_ECOLI Transcription modulator YdgT # BioGrid 4259630 18 # DISRUPTION PHENOTYPE At 0.3 M NaCl up-regulation of 1 gene and down-regulation of 6 genes was observed; a double cnu-hha deletion up-regulated 134 and down-regulated 5 genes, most of which are thought to have been acquired horizontally and are also up- regulated in double hns-stpA deletions (PubMed:23543115). {ECO 0000269|PubMed:23543115}. # EcoGene EG14303 cnu # FUNCTION CNU_ECOLI Modifies the set of genes regulated by H-NS; Hha and Cnu (YdgT) increase the number of genes bound by H-NS/StpA and may also modulate the oligomerization of the H-NS/StpA-complex on DNA (PubMed 23543115). The complex formed with H-NS binds to the specific 26-bp cnb site in the origin of replication oriC (PubMed 16199570). Can complement, at least partially, the absence of the Hha protein in hha mutants. {ECO 0000269|PubMed 16199570, ECO 0000269|PubMed 23543115}. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0060566 positive regulation of DNA-templated transcription, termination; IMP:EcoCyc. # GO_process GO:1900232 negative regulation of single-species biofilm formation on inanimate substrate; IMP:EcoCyc. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.20.1280.40 -; 1. # INTERACTION CNU_ECOLI P0ACF8 hns; NbExp=2; IntAct=EBI-551907, EBI-544934; # IntAct P64467 3 # InterPro IPR007985 Hemolysn_expr_modulating_HHA # MISCELLANEOUS CNU_ECOLI Expression becomes maximal as cells enter the stationary phase but decreases later in the stationary phase. # Organism CNU_ECOLI Escherichia coli (strain K12) # PATRIC 32118552 VBIEscCol129921_1696 # PDB 2JQT NMR; -; A=1-71 # PIR C64919 C64919 # Pfam PF05321 HHA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CNU_ECOLI OriC-binding nucleoid-associated protein # RefSeq NP_416142 NC_000913.3 # RefSeq WP_000217950 NZ_LN832404.1 # SIMILARITY Belongs to the Hha/YmoA/Cnu family. {ECO 0000305}. # SUBUNIT CNU_ECOLI Forms complexes with both H-NS and StpA. {ECO 0000269|PubMed 15458420, ECO 0000269|PubMed 16199570, ECO 0000269|PubMed 21600204}. # SUPFAM SSF68989 SSF68989 # eggNOG ENOG4105QZ5 Bacteria # eggNOG ENOG4111UG9 LUCA BLAST swissprot:CNU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CNU_ECOLI BioCyc ECOL316407:JW1617-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1617-MONOMER BioCyc EcoCyc:G6869-MONOMER http://biocyc.org/getid?id=EcoCyc:G6869-MONOMER DIP DIP-48011N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48011N DOI 10.1016/j.febslet.2011.05.024 http://dx.doi.org/10.1016/j.febslet.2011.05.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/dst008 http://dx.doi.org/10.1093/dnares/dst008 DOI 10.1111/j.1365-2958.2004.04268.x http://dx.doi.org/10.1111/j.1365-2958.2004.04268.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.187.20.6998-7008.2005 http://dx.doi.org/10.1128/JB.187.20.6998-7008.2005 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL AY442175 http://www.ebi.ac.uk/ena/data/view/AY442175 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4050 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4050 EcoGene EG14303 http://www.ecogene.org/geneInfo.php?eg_id=EG14303 EnsemblBacteria AAC74697 http://www.ensemblgenomes.org/id/AAC74697 EnsemblBacteria AAC74697 http://www.ensemblgenomes.org/id/AAC74697 EnsemblBacteria BAE76484 http://www.ensemblgenomes.org/id/BAE76484 EnsemblBacteria BAE76484 http://www.ensemblgenomes.org/id/BAE76484 EnsemblBacteria BAE76484 http://www.ensemblgenomes.org/id/BAE76484 EnsemblBacteria b1625 http://www.ensemblgenomes.org/id/b1625 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0060566 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060566 GO_process GO:1900232 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1900232 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.20.1280.40 http://www.cathdb.info/version/latest/superfamily/1.20.1280.40 GeneID 946152 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946152 HOGENOM HOG000219358 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219358&db=HOGENOM6 IntAct P64467 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P64467* InterPro IPR007985 http://www.ebi.ac.uk/interpro/entry/IPR007985 KEGG_Gene ecj:JW1617 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1617 KEGG_Gene eco:b1625 http://www.genome.jp/dbget-bin/www_bget?eco:b1625 MINT MINT-8175315 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8175315 OMA PKSVWHF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PKSVWHF PDB 2JQT http://www.ebi.ac.uk/pdbe-srv/view/entry/2JQT PDBsum 2JQT http://www.ebi.ac.uk/pdbsum/2JQT PSORT swissprot:CNU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CNU_ECOLI PSORT-B swissprot:CNU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CNU_ECOLI PSORT2 swissprot:CNU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CNU_ECOLI Pfam PF05321 http://pfam.xfam.org/family/PF05321 Phobius swissprot:CNU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CNU_ECOLI ProteinModelPortal P64467 http://www.proteinmodelportal.org/query/uniprot/P64467 PubMed 15458420 http://www.ncbi.nlm.nih.gov/pubmed/15458420 PubMed 16199570 http://www.ncbi.nlm.nih.gov/pubmed/16199570 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21600204 http://www.ncbi.nlm.nih.gov/pubmed/21600204 PubMed 23543115 http://www.ncbi.nlm.nih.gov/pubmed/23543115 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416142 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416142 RefSeq WP_000217950 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000217950 SMR P64467 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P64467 STRING 511145.b1625 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1625&targetmode=cogs SUPFAM SSF68989 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF68989 UniProtKB CNU_ECOLI http://www.uniprot.org/uniprot/CNU_ECOLI UniProtKB-AC P64467 http://www.uniprot.org/uniprot/P64467 charge swissprot:CNU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CNU_ECOLI eggNOG ENOG4105QZ5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105QZ5 eggNOG ENOG4111UG9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111UG9 epestfind swissprot:CNU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CNU_ECOLI garnier swissprot:CNU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CNU_ECOLI helixturnhelix swissprot:CNU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CNU_ECOLI hmoment swissprot:CNU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CNU_ECOLI iep swissprot:CNU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CNU_ECOLI inforesidue swissprot:CNU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CNU_ECOLI octanol swissprot:CNU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CNU_ECOLI pepcoil swissprot:CNU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CNU_ECOLI pepdigest swissprot:CNU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CNU_ECOLI pepinfo swissprot:CNU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CNU_ECOLI pepnet swissprot:CNU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CNU_ECOLI pepstats swissprot:CNU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CNU_ECOLI pepwheel swissprot:CNU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CNU_ECOLI pepwindow swissprot:CNU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CNU_ECOLI sigcleave swissprot:CNU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CNU_ECOLI ## Database ID URL or Descriptions # BioGrid 4263214 171 # EcoGene EG14213 hyfE # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0016651 oxidoreductase activity, acting on NAD(P)H; IEA:InterPro. # GO_process GO:0042773 ATP synthesis coupled electron transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006091 generation of precursor metabolites and energy # IntAct P0AEW1 2 # InterPro IPR001133 NADH_UbQ_OxRdtase_chain4L/K # KEGG_Brite ko01000 Enzymes # Organism HYFE_ECOLI Escherichia coli (strain K12) # PATRIC 32120357 VBIEscCol129921_2581 # PIR D65024 D65024 # Pfam PF00420 Oxidored_q2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HYFE_ECOLI Hydrogenase-4 component E # RefSeq NP_416980 NC_000913.3 # RefSeq WP_000147987 NZ_LN832404.1 # SUBCELLULAR LOCATION HYFE_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 3.D.1.9 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family # eggNOG COG4237 LUCA # eggNOG ENOG4107WQX Bacteria BLAST swissprot:HYFE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HYFE_ECOLI BioCyc ECOL316407:JW2470-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2470-MONOMER BioCyc EcoCyc:MONOMER0-142 http://biocyc.org/getid?id=EcoCyc:MONOMER0-142 DIP DIP-48020N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48020N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M63654 http://www.ebi.ac.uk/ena/data/view/M63654 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- EchoBASE EB3965 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3965 EcoGene EG14213 http://www.ecogene.org/geneInfo.php?eg_id=EG14213 EnsemblBacteria AAC75538 http://www.ensemblgenomes.org/id/AAC75538 EnsemblBacteria AAC75538 http://www.ensemblgenomes.org/id/AAC75538 EnsemblBacteria BAA16373 http://www.ensemblgenomes.org/id/BAA16373 EnsemblBacteria BAA16373 http://www.ensemblgenomes.org/id/BAA16373 EnsemblBacteria BAA16373 http://www.ensemblgenomes.org/id/BAA16373 EnsemblBacteria b2485 http://www.ensemblgenomes.org/id/b2485 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0016651 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016651 GO_process GO:0042773 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042773 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GeneID 945298 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945298 HOGENOM HOG000100583 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000100583&db=HOGENOM6 InParanoid P0AEW1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEW1 IntAct P0AEW1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEW1* IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR001133 http://www.ebi.ac.uk/interpro/entry/IPR001133 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2470 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2470 KEGG_Gene eco:b2485 http://www.genome.jp/dbget-bin/www_bget?eco:b2485 KEGG_Orthology KO:K12140 http://www.genome.jp/dbget-bin/www_bget?KO:K12140 MINT MINT-1289177 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1289177 OMA GMPMVVE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GMPMVVE PSORT swissprot:HYFE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HYFE_ECOLI PSORT-B swissprot:HYFE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HYFE_ECOLI PSORT2 swissprot:HYFE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HYFE_ECOLI Pfam PF00420 http://pfam.xfam.org/family/PF00420 Phobius swissprot:HYFE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HYFE_ECOLI ProteinModelPortal P0AEW1 http://www.proteinmodelportal.org/query/uniprot/P0AEW1 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416980 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416980 RefSeq WP_000147987 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000147987 STRING 511145.b2485 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2485&targetmode=cogs TCDB 3.D.1.9 http://www.tcdb.org/search/result.php?tc=3.D.1.9 UniProtKB HYFE_ECOLI http://www.uniprot.org/uniprot/HYFE_ECOLI UniProtKB-AC P0AEW1 http://www.uniprot.org/uniprot/P0AEW1 charge swissprot:HYFE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HYFE_ECOLI eggNOG COG4237 http://eggnogapi.embl.de/nog_data/html/tree/COG4237 eggNOG ENOG4107WQX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107WQX epestfind swissprot:HYFE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HYFE_ECOLI garnier swissprot:HYFE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HYFE_ECOLI helixturnhelix swissprot:HYFE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HYFE_ECOLI hmoment swissprot:HYFE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HYFE_ECOLI iep swissprot:HYFE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HYFE_ECOLI inforesidue swissprot:HYFE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HYFE_ECOLI octanol swissprot:HYFE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HYFE_ECOLI pepcoil swissprot:HYFE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HYFE_ECOLI pepdigest swissprot:HYFE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HYFE_ECOLI pepinfo swissprot:HYFE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HYFE_ECOLI pepnet swissprot:HYFE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HYFE_ECOLI pepstats swissprot:HYFE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HYFE_ECOLI pepwheel swissprot:HYFE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HYFE_ECOLI pepwindow swissprot:HYFE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HYFE_ECOLI sigcleave swissprot:HYFE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HYFE_ECOLI ## Database ID URL or Descriptions # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG12390 ybfI # GO_component GO:0005622 intracellular; IEA:GOC. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0000160 phosphorelay signal transduction system; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_component GO:0005622 intracellular # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # InterPro IPR001867 OmpR/PhoB-type_DNA-bd # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR016032 Sig_transdc_resp-reg_C-effctor # Organism YBFI_ECOLI Escherichia coli (strain K12) # PROSITE PS51755 OMPR_PHOB # Pfam PF00486 Trans_reg_C # Proteomes UP000000625 Chromosome # RecName YBFI_ECOLI Putative uncharacterized protein YbfI # SEQUENCE CAUTION Sequence=M64495; Type=Erroneous termination; Positions=21; Note=Translated as Xaa.; Evidence={ECO:0000305}; Sequence=U00096; Type=Erroneous termination; Positions=21; Note=Translated as Xaa.; Evidence={ECO 0000305}; # SIMILARITY Contains 1 OmpR/PhoB-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU01091}. # SUPFAM SSF46894 SSF46894 BLAST swissprot:YBFI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBFI_ECOLI DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL M64495 http://www.ebi.ac.uk/ena/data/view/M64495 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U08369 http://www.ebi.ac.uk/ena/data/view/U08369 EchoBASE EB2291 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2291 EcoGene EG12390 http://www.ecogene.org/geneInfo.php?eg_id=EG12390 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 InterPro IPR001867 http://www.ebi.ac.uk/interpro/entry/IPR001867 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR016032 http://www.ebi.ac.uk/interpro/entry/IPR016032 PROSITE PS51755 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51755 PSORT swissprot:YBFI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBFI_ECOLI PSORT-B swissprot:YBFI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBFI_ECOLI PSORT2 swissprot:YBFI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBFI_ECOLI Pfam PF00486 http://pfam.xfam.org/family/PF00486 Phobius swissprot:YBFI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBFI_ECOLI ProteinModelPortal P39901 http://www.proteinmodelportal.org/query/uniprot/P39901 PubMed 1939141 http://www.ncbi.nlm.nih.gov/pubmed/1939141 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 8083177 http://www.ncbi.nlm.nih.gov/pubmed/8083177 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SUPFAM SSF46894 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46894 UniProtKB YBFI_ECOLI http://www.uniprot.org/uniprot/YBFI_ECOLI UniProtKB-AC P39901 http://www.uniprot.org/uniprot/P39901 charge swissprot:YBFI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBFI_ECOLI epestfind swissprot:YBFI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBFI_ECOLI garnier swissprot:YBFI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBFI_ECOLI helixturnhelix swissprot:YBFI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBFI_ECOLI hmoment swissprot:YBFI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBFI_ECOLI iep swissprot:YBFI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBFI_ECOLI inforesidue swissprot:YBFI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBFI_ECOLI octanol swissprot:YBFI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBFI_ECOLI pepcoil swissprot:YBFI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBFI_ECOLI pepdigest swissprot:YBFI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBFI_ECOLI pepinfo swissprot:YBFI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBFI_ECOLI pepnet swissprot:YBFI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBFI_ECOLI pepstats swissprot:YBFI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBFI_ECOLI pepwheel swissprot:YBFI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBFI_ECOLI pepwindow swissprot:YBFI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBFI_ECOLI sigcleave swissprot:YBFI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBFI_ECOLI ## Database ID URL or Descriptions # AltName YDIV_ECOLI c-di-GMP regulator CdgR # BioGrid 4260299 10 # DISRUPTION PHENOTYPE YDIV_ECOLI A double sdiA/ydiV deletion mutant leads to decreased cAMP levels which inhibits quorum sensing system 2. Repressed by glucose. Unlike the case in Salmonella typhimurium, disruption has no effect on motility or FliC levels. {ECO 0000269|PubMed 18560382, ECO 0000269|PubMed 22461489}. # EcoGene EG13981 ydiV # FUNCTION YDIV_ECOLI Upon overexpression acts as a novel anti-FlhC(2)FlhD(4) factor, decreasing its DNA-binding activity, able to negatively regulate expression of flagellar class II operons including FliC. # GO_function GO:0008134 transcription factor binding; IPI:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity; IDA:EcoCyc. # GO_process GO:1902201 negative regulation of bacterial-type flagellum-dependent cell motility; IMP:EcoCyc. # GO_process GO:2000678 negative regulation of transcription regulatory region DNA binding; IDA:EcoCyc. # GOslim_function GO:0008134 transcription factor binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.20.20.450 -; 1. # INDUCTION YDIV_ECOLI Induced by extracellular autoinducer AI-1 (Vibrio fischeri autoinducer oxoC6), in an SdiA-dependent fashion. Repressed by glucose. Induced at pH 5.0 in an RpoS-dependent fashion. Very poorly expressed in both rich and nutrient-poor medium due to inefficient translation (at protein level). {ECO 0000269|PubMed 17010156, ECO 0000269|PubMed 18560382, ECO 0000269|PubMed 22461489}. # IntAct P76204 5 # InterPro IPR001633 EAL_dom # Organism YDIV_ECOLI Escherichia coli (strain K12) # PATRIC 32118720 VBIEscCol129921_1778 # PDB 3TLQ X-ray; 1.91 A; A/B=1-237 # PDB 4ES4 X-ray; 2.90 A; A/C/E/G=1-237 # PIR C64929 C64929 # Pfam PF00563 EAL # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDIV_ECOLI Putative anti-FlhC(2)FlhD(4) factor YdiV # RefSeq NP_416222 NC_000913.3 # RefSeq WP_001300634 NZ_LN832404.1 # SIMILARITY Belongs to the YdiV family. {ECO 0000305}. # SIMILARITY Contains 1 EAL domain. {ECO 0000305}. # SUPFAM SSF141868 SSF141868 # eggNOG COG2200 LUCA # eggNOG ENOG4108TC0 Bacteria BLAST swissprot:YDIV_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDIV_ECOLI BioCyc ECOL316407:JW1697-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1697-MONOMER BioCyc EcoCyc:G6925-MONOMER http://biocyc.org/getid?id=EcoCyc:G6925-MONOMER DIP DIP-11763N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11763N DOI 10.1038/cr.2008.67 http://dx.doi.org/10.1038/cr.2008.67 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1099/mic.0.056036-0 http://dx.doi.org/10.1099/mic.0.056036-0 DOI 10.1111/j.1365-2958.2006.05440.x http://dx.doi.org/10.1111/j.1365-2958.2006.05440.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3738 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3738 EcoGene EG13981 http://www.ecogene.org/geneInfo.php?eg_id=EG13981 EnsemblBacteria AAC74777 http://www.ensemblgenomes.org/id/AAC74777 EnsemblBacteria AAC74777 http://www.ensemblgenomes.org/id/AAC74777 EnsemblBacteria BAE76505 http://www.ensemblgenomes.org/id/BAE76505 EnsemblBacteria BAE76505 http://www.ensemblgenomes.org/id/BAE76505 EnsemblBacteria BAE76505 http://www.ensemblgenomes.org/id/BAE76505 EnsemblBacteria b1707 http://www.ensemblgenomes.org/id/b1707 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008134 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008134 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0043433 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043433 GO_process GO:1902201 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902201 GO_process GO:2000678 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000678 GOslim_function GO:0008134 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008134 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.20.20.450 http://www.cathdb.info/version/latest/superfamily/3.20.20.450 GeneID 946217 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946217 HOGENOM HOG000120996 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120996&db=HOGENOM6 IntAct P76204 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76204* InterPro IPR001633 http://www.ebi.ac.uk/interpro/entry/IPR001633 KEGG_Gene ecj:JW1697 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1697 KEGG_Gene eco:b1707 http://www.genome.jp/dbget-bin/www_bget?eco:b1707 OMA SFEPFMR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SFEPFMR PDB 3TLQ http://www.ebi.ac.uk/pdbe-srv/view/entry/3TLQ PDB 4ES4 http://www.ebi.ac.uk/pdbe-srv/view/entry/4ES4 PDBsum 3TLQ http://www.ebi.ac.uk/pdbsum/3TLQ PDBsum 4ES4 http://www.ebi.ac.uk/pdbsum/4ES4 PSORT swissprot:YDIV_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDIV_ECOLI PSORT-B swissprot:YDIV_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDIV_ECOLI PSORT2 swissprot:YDIV_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDIV_ECOLI Pfam PF00563 http://pfam.xfam.org/family/PF00563 Phobius swissprot:YDIV_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDIV_ECOLI ProteinModelPortal P76204 http://www.proteinmodelportal.org/query/uniprot/P76204 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17010156 http://www.ncbi.nlm.nih.gov/pubmed/17010156 PubMed 18560382 http://www.ncbi.nlm.nih.gov/pubmed/18560382 PubMed 22461489 http://www.ncbi.nlm.nih.gov/pubmed/22461489 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416222 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416222 RefSeq WP_001300634 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300634 SMR P76204 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76204 STRING 511145.b1707 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1707&targetmode=cogs SUPFAM SSF141868 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF141868 UniProtKB YDIV_ECOLI http://www.uniprot.org/uniprot/YDIV_ECOLI UniProtKB-AC P76204 http://www.uniprot.org/uniprot/P76204 charge swissprot:YDIV_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDIV_ECOLI eggNOG COG2200 http://eggnogapi.embl.de/nog_data/html/tree/COG2200 eggNOG ENOG4108TC0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108TC0 epestfind swissprot:YDIV_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDIV_ECOLI garnier swissprot:YDIV_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDIV_ECOLI helixturnhelix swissprot:YDIV_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDIV_ECOLI hmoment swissprot:YDIV_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDIV_ECOLI iep swissprot:YDIV_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDIV_ECOLI inforesidue swissprot:YDIV_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDIV_ECOLI octanol swissprot:YDIV_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDIV_ECOLI pepcoil swissprot:YDIV_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDIV_ECOLI pepdigest swissprot:YDIV_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDIV_ECOLI pepinfo swissprot:YDIV_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDIV_ECOLI pepnet swissprot:YDIV_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDIV_ECOLI pepstats swissprot:YDIV_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDIV_ECOLI pepwheel swissprot:YDIV_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDIV_ECOLI pepwindow swissprot:YDIV_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDIV_ECOLI sigcleave swissprot:YDIV_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDIV_ECOLI ## Database ID URL or Descriptions # AltName FXSA_ECOLI Suppressor of F exclusion of phage T7 # BioGrid 4262196 11 # EcoGene EG12382 fxsA # FUNCTION FXSA_ECOLI Overexpression alleviates the exclusion of phage T7 in cells harboring the F plasmid. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # IntAct P37147 3 # InterPro IPR007313 FxsA # Organism FXSA_ECOLI Escherichia coli (strain K12) # PATRIC 32123849 VBIEscCol129921_4272 # PIR S56368 S56368 # Pfam PF04186 FxsA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FXSA_ECOLI UPF0716 protein FxsA # RefSeq NP_418564 NC_000913.3 # RefSeq WP_001267448 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97039.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA27700.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the UPF0716 (FxsA) family. {ECO 0000305}. # SUBCELLULAR LOCATION FXSA_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG COG3030 LUCA # eggNOG ENOG4108YH1 Bacteria BLAST swissprot:FXSA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FXSA_ECOLI BioCyc ECOL316407:JW4100-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4100-MONOMER BioCyc EcoCyc:G7832-MONOMER http://biocyc.org/getid?id=EcoCyc:G7832-MONOMER COG COG3030 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3030 DOI 10.1006/jmbi.1999.3087 http://dx.doi.org/10.1006/jmbi.1999.3087 DOI 10.1006/jmbi.1999.3088 http://dx.doi.org/10.1006/jmbi.1999.3088 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2370547 http://dx.doi.org/10.1042/bj2370547 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL U78484 http://www.ebi.ac.uk/ena/data/view/U78484 EMBL X04066 http://www.ebi.ac.uk/ena/data/view/X04066 EchoBASE EB2284 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2284 EcoGene EG12382 http://www.ecogene.org/geneInfo.php?eg_id=EG12382 EnsemblBacteria AAC77100 http://www.ensemblgenomes.org/id/AAC77100 EnsemblBacteria AAC77100 http://www.ensemblgenomes.org/id/AAC77100 EnsemblBacteria BAE78142 http://www.ensemblgenomes.org/id/BAE78142 EnsemblBacteria BAE78142 http://www.ensemblgenomes.org/id/BAE78142 EnsemblBacteria BAE78142 http://www.ensemblgenomes.org/id/BAE78142 EnsemblBacteria b4140 http://www.ensemblgenomes.org/id/b4140 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 948657 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948657 HOGENOM HOG000272432 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000272432&db=HOGENOM6 InParanoid P37147 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37147 IntAct P37147 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37147* InterPro IPR007313 http://www.ebi.ac.uk/interpro/entry/IPR007313 KEGG_Gene ecj:JW4100 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4100 KEGG_Gene eco:b4140 http://www.genome.jp/dbget-bin/www_bget?eco:b4140 KEGG_Orthology KO:K07113 http://www.genome.jp/dbget-bin/www_bget?KO:K07113 OMA QGIQTLM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QGIQTLM PSORT swissprot:FXSA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FXSA_ECOLI PSORT-B swissprot:FXSA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FXSA_ECOLI PSORT2 swissprot:FXSA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FXSA_ECOLI Pfam PF04186 http://pfam.xfam.org/family/PF04186 Phobius swissprot:FXSA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FXSA_ECOLI ProteinModelPortal P37147 http://www.proteinmodelportal.org/query/uniprot/P37147 PubMed 10497016 http://www.ncbi.nlm.nih.gov/pubmed/10497016 PubMed 10497017 http://www.ncbi.nlm.nih.gov/pubmed/10497017 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3541901 http://www.ncbi.nlm.nih.gov/pubmed/3541901 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418564 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418564 RefSeq WP_001267448 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001267448 STRING 511145.b4140 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4140&targetmode=cogs STRING COG3030 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3030&targetmode=cogs UniProtKB FXSA_ECOLI http://www.uniprot.org/uniprot/FXSA_ECOLI UniProtKB-AC P37147 http://www.uniprot.org/uniprot/P37147 charge swissprot:FXSA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FXSA_ECOLI eggNOG COG3030 http://eggnogapi.embl.de/nog_data/html/tree/COG3030 eggNOG ENOG4108YH1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108YH1 epestfind swissprot:FXSA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FXSA_ECOLI garnier swissprot:FXSA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FXSA_ECOLI helixturnhelix swissprot:FXSA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FXSA_ECOLI hmoment swissprot:FXSA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FXSA_ECOLI iep swissprot:FXSA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FXSA_ECOLI inforesidue swissprot:FXSA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FXSA_ECOLI octanol swissprot:FXSA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FXSA_ECOLI pepcoil swissprot:FXSA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FXSA_ECOLI pepdigest swissprot:FXSA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FXSA_ECOLI pepinfo swissprot:FXSA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FXSA_ECOLI pepnet swissprot:FXSA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FXSA_ECOLI pepstats swissprot:FXSA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FXSA_ECOLI pepwheel swissprot:FXSA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FXSA_ECOLI pepwindow swissprot:FXSA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FXSA_ECOLI sigcleave swissprot:FXSA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FXSA_ECOLI ## Database ID URL or Descriptions # AltName FKBA_ECOLI Rotamase # BRENDA 5.2.1 2026 # BioGrid 4263165 8 # CATALYTIC ACTIVITY FKBA_ECOLI Peptidylproline (omega=180) = peptidylproline (omega=0). # EcoGene EG12900 fkpA # FUNCTION FKBA_ECOLI PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0003755 peptidyl-prolyl cis-trans isomerase activity; IBA:GO_Central. # GO_function GO:0005528 FK506 binding; IBA:GO_Central. # GO_process GO:0042026 protein refolding; IDA:EcoliWiki. # GO_process GO:0061077 chaperone-mediated protein folding; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0006457 protein folding # Gene3D 1.10.287.460 -; 1. # IntAct P45523 17 # InterPro IPR000774 PPIase_FKBP_N # InterPro IPR001179 PPIase_FKBP_dom # InterPro IPR023566 PPIase_FKBP # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03110 Chaperones and folding catalysts # Organism FKBA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10516 PTHR10516 # PATRIC 32122126 VBIEscCol129921_3440 # PDB 1Q6H X-ray; 1.97 A; A/B=26-249 # PDB 1Q6I X-ray; 2.25 A; A/B=26-249 # PDB 1Q6U X-ray; 2.45 A; A=26-270 # PIR I65035 I65035 # PROSITE PS50059 FKBP_PPIASE # Pfam PF00254 FKBP_C # Pfam PF01346 FKBP_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FKBA_ECOLI FKBP-type peptidyl-prolyl cis-trans isomerase FkpA # RefSeq NP_417806 NC_000913.3 # RefSeq WP_000838250 NZ_LN832404.1 # SIMILARITY Belongs to the FKBP-type PPIase family. {ECO 0000305}. # SIMILARITY Contains 1 PPIase FKBP-type domain. {ECO:0000255|PROSITE-ProRule PRU00277}. # SUBCELLULAR LOCATION FKBA_ECOLI Periplasm. # eggNOG COG0545 LUCA # eggNOG ENOG4108V1T Bacteria BLAST swissprot:FKBA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FKBA_ECOLI BioCyc ECOL316407:JW3309-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3309-MONOMER BioCyc EcoCyc:G7716-MONOMER http://biocyc.org/getid?id=EcoCyc:G7716-MONOMER COG COG0545 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0545 DIP DIP-9625N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9625N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1007/BF00404209 http://dx.doi.org/10.1007/BF00404209 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1996.561412.x http://dx.doi.org/10.1046/j.1365-2958.1996.561412.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.2.1.8 http://www.genome.jp/dbget-bin/www_bget?EC:5.2.1.8 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L28082 http://www.ebi.ac.uk/ena/data/view/L28082 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 5.2.1.8 http://enzyme.expasy.org/EC/5.2.1.8 EchoBASE EB2737 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2737 EcoGene EG12900 http://www.ecogene.org/geneInfo.php?eg_id=EG12900 EnsemblBacteria AAC76372 http://www.ensemblgenomes.org/id/AAC76372 EnsemblBacteria AAC76372 http://www.ensemblgenomes.org/id/AAC76372 EnsemblBacteria BAE77944 http://www.ensemblgenomes.org/id/BAE77944 EnsemblBacteria BAE77944 http://www.ensemblgenomes.org/id/BAE77944 EnsemblBacteria BAE77944 http://www.ensemblgenomes.org/id/BAE77944 EnsemblBacteria b3347 http://www.ensemblgenomes.org/id/b3347 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0003755 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003755 GO_function GO:0005528 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005528 GO_process GO:0042026 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042026 GO_process GO:0061077 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061077 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 Gene3D 1.10.287.460 http://www.cathdb.info/version/latest/superfamily/1.10.287.460 GeneID 947850 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947850 HOGENOM HOG000154888 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000154888&db=HOGENOM6 InParanoid P45523 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45523 IntAct P45523 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45523* IntEnz 5.2.1.8 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.2.1.8 InterPro IPR000774 http://www.ebi.ac.uk/interpro/entry/IPR000774 InterPro IPR001179 http://www.ebi.ac.uk/interpro/entry/IPR001179 InterPro IPR023566 http://www.ebi.ac.uk/interpro/entry/IPR023566 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW3309 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3309 KEGG_Gene eco:b3347 http://www.genome.jp/dbget-bin/www_bget?eco:b3347 KEGG_Orthology KO:K03772 http://www.genome.jp/dbget-bin/www_bget?KO:K03772 MINT MINT-1228098 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1228098 OMA TENASKG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TENASKG PANTHER PTHR10516 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10516 PDB 1Q6H http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q6H PDB 1Q6I http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q6I PDB 1Q6U http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q6U PDBsum 1Q6H http://www.ebi.ac.uk/pdbsum/1Q6H PDBsum 1Q6I http://www.ebi.ac.uk/pdbsum/1Q6I PDBsum 1Q6U http://www.ebi.ac.uk/pdbsum/1Q6U PROSITE PS50059 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50059 PSORT swissprot:FKBA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FKBA_ECOLI PSORT-B swissprot:FKBA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FKBA_ECOLI PSORT2 swissprot:FKBA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FKBA_ECOLI Pfam PF00254 http://pfam.xfam.org/family/PF00254 Pfam PF01346 http://pfam.xfam.org/family/PF01346 Phobius swissprot:FKBA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FKBA_ECOLI PhylomeDB P45523 http://phylomedb.org/?seqid=P45523 ProteinModelPortal P45523 http://www.proteinmodelportal.org/query/uniprot/P45523 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7540828 http://www.ncbi.nlm.nih.gov/pubmed/7540828 PubMed 8878048 http://www.ncbi.nlm.nih.gov/pubmed/8878048 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_417806 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417806 RefSeq WP_000838250 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000838250 SMR P45523 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45523 STRING 511145.b3347 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3347&targetmode=cogs STRING COG0545 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0545&targetmode=cogs SWISS-2DPAGE P45523 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P45523 UniProtKB FKBA_ECOLI http://www.uniprot.org/uniprot/FKBA_ECOLI UniProtKB-AC P45523 http://www.uniprot.org/uniprot/P45523 charge swissprot:FKBA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FKBA_ECOLI eggNOG COG0545 http://eggnogapi.embl.de/nog_data/html/tree/COG0545 eggNOG ENOG4108V1T http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108V1T epestfind swissprot:FKBA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FKBA_ECOLI garnier swissprot:FKBA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FKBA_ECOLI helixturnhelix swissprot:FKBA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FKBA_ECOLI hmoment swissprot:FKBA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FKBA_ECOLI iep swissprot:FKBA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FKBA_ECOLI inforesidue swissprot:FKBA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FKBA_ECOLI octanol swissprot:FKBA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FKBA_ECOLI pepcoil swissprot:FKBA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FKBA_ECOLI pepdigest swissprot:FKBA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FKBA_ECOLI pepinfo swissprot:FKBA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FKBA_ECOLI pepnet swissprot:FKBA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FKBA_ECOLI pepstats swissprot:FKBA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FKBA_ECOLI pepwheel swissprot:FKBA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FKBA_ECOLI pepwindow swissprot:FKBA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FKBA_ECOLI sigcleave swissprot:FKBA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FKBA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260696 24 # DISRUPTION PHENOTYPE Mutation reduces both the rate and the extent of ProP activation by an osmotic upshift, but does not impair transcription or translation of proP. {ECO:0000269|PubMed 10049386}. # DOMAIN PROQ_ECOLI Contains an alpha-helical N-terminal domain (FinO-like) and a beta-sheet C-terminal domain (Hfq-like), connected by an unstructured linker. The FinO-like domain serves as a high- affinity RNA-binding domain, whereas the Hfq-like domain is largely responsible for RNA strand exchange and duplexing. {ECO 0000269|PubMed 15476391, ECO 0000269|PubMed 17319698, ECO 0000269|PubMed 21381725}. # EcoGene EG12866 proQ # FUNCTION PROQ_ECOLI RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities. May regulate ProP activity through an RNA-based, post-transcriptional mechanism. {ECO 0000255|HAMAP-Rule MF_00749, ECO 0000269|PubMed 21381725}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0033592 RNA strand annealing activity; IDA:EcoCyc. # GO_function GO:0034057 RNA strand-exchange activity; IDA:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IMP:EcoCyc. # GO_process GO:0010608 posttranscriptional regulation of gene expression; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # Gene3D 1.10.1710.10 -; 1. # HAMAP MF_00749 ProQ # INTERACTION PROQ_ECOLI P0ACZ4 evgA; NbExp=3; IntAct=EBI-8767901, EBI-548694; # IntAct P45577 43 # InterPro IPR016103 ProQ/FinO # InterPro IPR023529 ProQ # Organism PROQ_ECOLI Escherichia coli (strain K12) # PATRIC 32118983 VBIEscCol129921_1909 # PIR G64944 G64944 # Pfam PF04352 ProQ # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RNA chaperone ProQ {ECO:0000255|HAMAP-Rule MF_00749} # RefSeq WP_000431381 NZ_LN832404.1 # RefSeq YP_026161 NC_000913.3 # SEQUENCE CAUTION Sequence=BAA20566.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA20566.1; Type=Frameshift; Positions=151; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ProQ family. {ECO:0000255|HAMAP- Rule MF_00749}. # SMART SM00945 ProQ # SUBCELLULAR LOCATION PROQ_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00749, ECO 0000269|PubMed 10049386, ECO 0000269|PubMed 15476391}. # SUPFAM SSF48657 SSF48657 # eggNOG COG3109 LUCA # eggNOG ENOG41073DY Bacteria BLAST swissprot:PROQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PROQ_ECOLI BioCyc ECOL316407:JW5300-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5300-MONOMER BioCyc EcoCyc:EG12866-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12866-MONOMER COG COG3109 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3109 DIP DIP-10572N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10572N DOI 10.1021/bi048561g http://dx.doi.org/10.1021/bi048561g DOI 10.1021/bi101683a http://dx.doi.org/10.1021/bi101683a DOI 10.1021/bi6023786 http://dx.doi.org/10.1021/bi6023786 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DisProt DP00377 http://www.disprot.org/protein.php?id=DP00377 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D00674 http://www.ebi.ac.uk/ena/data/view/D00674 EMBL L48409 http://www.ebi.ac.uk/ena/data/view/L48409 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2707 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2707 EcoGene EG12866 http://www.ecogene.org/geneInfo.php?eg_id=EG12866 EnsemblBacteria AAC74901 http://www.ensemblgenomes.org/id/AAC74901 EnsemblBacteria AAC74901 http://www.ensemblgenomes.org/id/AAC74901 EnsemblBacteria BAA15639 http://www.ensemblgenomes.org/id/BAA15639 EnsemblBacteria BAA15639 http://www.ensemblgenomes.org/id/BAA15639 EnsemblBacteria BAA15639 http://www.ensemblgenomes.org/id/BAA15639 EnsemblBacteria b1831 http://www.ensemblgenomes.org/id/b1831 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0033592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033592 GO_function GO:0034057 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034057 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0010608 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010608 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.10.1710.10 http://www.cathdb.info/version/latest/superfamily/1.10.1710.10 GeneID 948950 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948950 HAMAP MF_00749 http://hamap.expasy.org/unirule/MF_00749 HOGENOM HOG000290843 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000290843&db=HOGENOM6 IntAct P45577 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45577* InterPro IPR016103 http://www.ebi.ac.uk/interpro/entry/IPR016103 InterPro IPR023529 http://www.ebi.ac.uk/interpro/entry/IPR023529 KEGG_Gene ecj:JW5300 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5300 KEGG_Gene eco:b1831 http://www.genome.jp/dbget-bin/www_bget?eco:b1831 KEGG_Orthology KO:K03607 http://www.genome.jp/dbget-bin/www_bget?KO:K03607 OMA GELEQQH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GELEQQH PSORT swissprot:PROQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PROQ_ECOLI PSORT-B swissprot:PROQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PROQ_ECOLI PSORT2 swissprot:PROQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PROQ_ECOLI Pfam PF04352 http://pfam.xfam.org/family/PF04352 Phobius swissprot:PROQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PROQ_ECOLI ProteinModelPortal P45577 http://www.proteinmodelportal.org/query/uniprot/P45577 PubMed 10049386 http://www.ncbi.nlm.nih.gov/pubmed/10049386 PubMed 15476391 http://www.ncbi.nlm.nih.gov/pubmed/15476391 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17319698 http://www.ncbi.nlm.nih.gov/pubmed/17319698 PubMed 1856173 http://www.ncbi.nlm.nih.gov/pubmed/1856173 PubMed 21381725 http://www.ncbi.nlm.nih.gov/pubmed/21381725 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000431381 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000431381 RefSeq YP_026161 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026161 SMART SM00945 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00945 SMR P45577 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45577 STRING 511145.b1831 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1831&targetmode=cogs STRING COG3109 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3109&targetmode=cogs SUPFAM SSF48657 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48657 UniProtKB PROQ_ECOLI http://www.uniprot.org/uniprot/PROQ_ECOLI UniProtKB-AC P45577 http://www.uniprot.org/uniprot/P45577 charge swissprot:PROQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PROQ_ECOLI eggNOG COG3109 http://eggnogapi.embl.de/nog_data/html/tree/COG3109 eggNOG ENOG41073DY http://eggnogapi.embl.de/nog_data/html/tree/ENOG41073DY epestfind swissprot:PROQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PROQ_ECOLI garnier swissprot:PROQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PROQ_ECOLI helixturnhelix swissprot:PROQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PROQ_ECOLI hmoment swissprot:PROQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PROQ_ECOLI iep swissprot:PROQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PROQ_ECOLI inforesidue swissprot:PROQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PROQ_ECOLI octanol swissprot:PROQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PROQ_ECOLI pepcoil swissprot:PROQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PROQ_ECOLI pepdigest swissprot:PROQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PROQ_ECOLI pepinfo swissprot:PROQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PROQ_ECOLI pepnet swissprot:PROQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PROQ_ECOLI pepstats swissprot:PROQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PROQ_ECOLI pepwheel swissprot:PROQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PROQ_ECOLI pepwindow swissprot:PROQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PROQ_ECOLI sigcleave swissprot:PROQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PROQ_ECOLI ## Database ID URL or Descriptions # AltName COPA_ECOLI Cu(+)-exporting ATPase # BIOPHYSICOCHEMICAL PROPERTIES COPA_ECOLI Kinetic parameters KM=1.5 uM for copper {ECO 0000269|PubMed 12351646}; KM=0.5 mM for ATP {ECO 0000269|PubMed 12351646}; Vmax=0.19 umol/min/mg enzyme (in the presence of Cu(+)) {ECO 0000269|PubMed 12351646}; # BioGrid 4261336 9 # CATALYTIC ACTIVITY COPA_ECOLI ATP + H(2)O + Cu(+)(Side 1) = ADP + phosphate + Cu(+)(Side 2). # CDD cd00371 HMA; 2 # ENZYME REGULATION Phosphorylation is inhibited by vanadate and sensitive to KOH and hydroxylamine. Phosphorylation is Cu(+)- dependent. {ECO:0000269|PubMed 12351646}. # EcoGene EG13246 copA # FUNCTION COPA_ECOLI Involved in copper export. May also be involved in silver export. {ECO 0000269|PubMed 12832075}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; ISM:EcoCyc. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_component GO:0031224 intrinsic component of membrane; IDA:EcoliWiki. # GO_component GO:0043231 intracellular membrane-bounded organelle; IBA:GO_Central. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0015080 silver ion transmembrane transporter activity; IMP:EcoCyc. # GO_function GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism; IDA:EcoCyc. # GO_function GO:0016887 ATPase activity; IDA:EcoliWiki. # GO_function GO:0043682 copper-transporting ATPase activity; IBA:GO_Central. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006825 copper ion transport; IMP:EcoliWiki. # GO_process GO:0010273 detoxification of copper ion; IMP:EcoliWiki. # GO_process GO:0060003 copper ion export; IDA:EcoCyc. # GO_process GO:0071280 cellular response to copper ion; IEP:EcoCyc. # GO_process GO:0071292 cellular response to silver ion; IEP:EcoCyc. # GO_process GO:1902601 silver ion transmembrane transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043226 organelle # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # GOslim_process GO:0055085 transmembrane transport # Gene3D 2.70.150.10 -; 1. # Gene3D 3.40.1110.10 -; 1. # Gene3D 3.40.50.1000 -; 2. # INDUCTION COPA_ECOLI Transcriptionally regulated by CueR in response to Cu(+) or Ag(+) ions. # IntAct Q59385 6 # InterPro IPR001757 P_typ_ATPase # InterPro IPR006121 HMA_dom # InterPro IPR008250 ATPase_P-typ_transduc_dom_A # InterPro IPR017969 Heavy-metal-associated_CS # InterPro IPR018303 ATPase_P-typ_P_site # InterPro IPR023214 HAD-like_dom # InterPro IPR023299 ATPase_P-typ_cyto_domN # InterPro IPR027256 P-typ_ATPase_IB # KEGG_Brite ko01000 Enzymes # Organism COPA_ECOLI Escherichia coli (strain K12) # PATRIC 32116127 VBIEscCol129921_0505 # PIR C64779 C64779 # PRINTS PR00120 HATPASE # PROSITE PS00154 ATPASE_E1_E2 # PROSITE PS01047 HMA_1 # PROSITE PS50846 HMA_2; 2 # Pfam PF00122 E1-E2_ATPase # Pfam PF00403 HMA; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName COPA_ECOLI Copper-exporting P-type ATPase A # RefSeq NP_415017 NC_000913.3 # RefSeq WP_000083955 NZ_LN832404.1 # SIMILARITY Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. {ECO 0000305}. # SIMILARITY Contains 2 HMA domains. {ECO:0000255|PROSITE- ProRule PRU00280}. # SUBCELLULAR LOCATION COPA_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # SUPFAM SSF55008 SSF55008; 2 # SUPFAM SSF56784 SSF56784; 2 # TCDB 3.A.3.5 the p-type atpase (p-atpase) superfamily # TIGRFAMs TIGR01494 ATPase_P-type # TIGRFAMs TIGR01525 ATPase-IB_hvy # eggNOG COG2217 LUCA # eggNOG ENOG4105C59 Bacteria BLAST swissprot:COPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:COPA_ECOLI BioCyc ECOL316407:JW0473-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0473-MONOMER BioCyc EcoCyc:G6260-MONOMER http://biocyc.org/getid?id=EcoCyc:G6260-MONOMER BioCyc MetaCyc:G6260-MONOMER http://biocyc.org/getid?id=MetaCyc:G6260-MONOMER COG COG2217 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2217 DOI 10.1006/bbrc.2001.5367 http://dx.doi.org/10.1006/bbrc.2001.5367 DOI 10.1016/S0014-5793(03)00640-9 http://dx.doi.org/10.1016/S0014-5793(03)00640-9 DOI 10.1016/S0378-1119(00)00509-6 http://dx.doi.org/10.1016/S0378-1119(00)00509-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.97.2.652 http://dx.doi.org/10.1073/pnas.97.2.652 DOI 10.1074/jbc.M208490200 http://dx.doi.org/10.1074/jbc.M208490200 DOI 10.1111/j.1574-6968.1998.tb13343.x http://dx.doi.org/10.1111/j.1574-6968.1998.tb13343.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.3.54 http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.54 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U58330 http://www.ebi.ac.uk/ena/data/view/U58330 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 ENZYME 3.6.3.54 http://enzyme.expasy.org/EC/3.6.3.54 EchoBASE EB3035 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3035 EcoGene EG13246 http://www.ecogene.org/geneInfo.php?eg_id=EG13246 EnsemblBacteria AAC73586 http://www.ensemblgenomes.org/id/AAC73586 EnsemblBacteria AAC73586 http://www.ensemblgenomes.org/id/AAC73586 EnsemblBacteria BAE76263 http://www.ensemblgenomes.org/id/BAE76263 EnsemblBacteria BAE76263 http://www.ensemblgenomes.org/id/BAE76263 EnsemblBacteria BAE76263 http://www.ensemblgenomes.org/id/BAE76263 EnsemblBacteria b0484 http://www.ensemblgenomes.org/id/b0484 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0031224 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031224 GO_component GO:0043231 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0015080 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015080 GO_function GO:0015662 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015662 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_function GO:0043682 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043682 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006825 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006825 GO_process GO:0010273 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010273 GO_process GO:0060003 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060003 GO_process GO:0071280 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071280 GO_process GO:0071292 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071292 GO_process GO:1902601 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902601 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 2.70.150.10 http://www.cathdb.info/version/latest/superfamily/2.70.150.10 Gene3D 3.40.1110.10 http://www.cathdb.info/version/latest/superfamily/3.40.1110.10 Gene3D 3.40.50.1000 http://www.cathdb.info/version/latest/superfamily/3.40.50.1000 GeneID 946106 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946106 HOGENOM HOG000250397 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000250397&db=HOGENOM6 InParanoid Q59385 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q59385 IntAct Q59385 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q59385* IntEnz 3.6.3.54 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.54 InterPro IPR001757 http://www.ebi.ac.uk/interpro/entry/IPR001757 InterPro IPR006121 http://www.ebi.ac.uk/interpro/entry/IPR006121 InterPro IPR008250 http://www.ebi.ac.uk/interpro/entry/IPR008250 InterPro IPR017969 http://www.ebi.ac.uk/interpro/entry/IPR017969 InterPro IPR018303 http://www.ebi.ac.uk/interpro/entry/IPR018303 InterPro IPR023214 http://www.ebi.ac.uk/interpro/entry/IPR023214 InterPro IPR023299 http://www.ebi.ac.uk/interpro/entry/IPR023299 InterPro IPR027256 http://www.ebi.ac.uk/interpro/entry/IPR027256 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0473 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0473 KEGG_Gene eco:b0484 http://www.genome.jp/dbget-bin/www_bget?eco:b0484 KEGG_Orthology KO:K01533 http://www.genome.jp/dbget-bin/www_bget?KO:K01533 OMA QDGSTDH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QDGSTDH PRINTS PR00120 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00120 PROSITE PS00154 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00154 PROSITE PS01047 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01047 PROSITE PS50846 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50846 PSORT swissprot:COPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:COPA_ECOLI PSORT-B swissprot:COPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:COPA_ECOLI PSORT2 swissprot:COPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:COPA_ECOLI Pfam PF00122 http://pfam.xfam.org/family/PF00122 Pfam PF00403 http://pfam.xfam.org/family/PF00403 Phobius swissprot:COPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:COPA_ECOLI PhylomeDB Q59385 http://phylomedb.org/?seqid=Q59385 ProteinModelPortal Q59385 http://www.proteinmodelportal.org/query/uniprot/Q59385 PubMed 10639134 http://www.ncbi.nlm.nih.gov/pubmed/10639134 PubMed 11167016 http://www.ncbi.nlm.nih.gov/pubmed/11167016 PubMed 11500054 http://www.ncbi.nlm.nih.gov/pubmed/11500054 PubMed 12351646 http://www.ncbi.nlm.nih.gov/pubmed/12351646 PubMed 12832075 http://www.ncbi.nlm.nih.gov/pubmed/12832075 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9868784 http://www.ncbi.nlm.nih.gov/pubmed/9868784 RefSeq NP_415017 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415017 RefSeq WP_000083955 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000083955 STRING 511145.b0484 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0484&targetmode=cogs STRING COG2217 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2217&targetmode=cogs SUPFAM SSF55008 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55008 SUPFAM SSF56784 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784 TCDB 3.A.3.5 http://www.tcdb.org/search/result.php?tc=3.A.3.5 TIGRFAMs TIGR01494 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01494 TIGRFAMs TIGR01525 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01525 UniProtKB COPA_ECOLI http://www.uniprot.org/uniprot/COPA_ECOLI UniProtKB-AC Q59385 http://www.uniprot.org/uniprot/Q59385 charge swissprot:COPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:COPA_ECOLI eggNOG COG2217 http://eggnogapi.embl.de/nog_data/html/tree/COG2217 eggNOG ENOG4105C59 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C59 epestfind swissprot:COPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:COPA_ECOLI garnier swissprot:COPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:COPA_ECOLI helixturnhelix swissprot:COPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:COPA_ECOLI hmoment swissprot:COPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:COPA_ECOLI iep swissprot:COPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:COPA_ECOLI inforesidue swissprot:COPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:COPA_ECOLI octanol swissprot:COPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:COPA_ECOLI pepcoil swissprot:COPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:COPA_ECOLI pepdigest swissprot:COPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:COPA_ECOLI pepinfo swissprot:COPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:COPA_ECOLI pepnet swissprot:COPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:COPA_ECOLI pepstats swissprot:COPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:COPA_ECOLI pepwheel swissprot:COPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:COPA_ECOLI pepwindow swissprot:COPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:COPA_ECOLI sigcleave swissprot:COPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:COPA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261407 377 # CATALYTIC ACTIVITY ETP_ECOLI Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. # CAUTION In E.coli K12 / MG1655 and K12 / W3110 this operon is silenced by an IS1D insertion in the promoter region. {ECO 0000305}. # CDD cd00115 LMWPc # EcoGene EG13727 etp # FUNCTION ETP_ECOLI Dephosphorylates etk. # GO_function GO:0004725 protein tyrosine phosphatase activity; IDA:EcoCyc. # GO_process GO:0035335 peptidyl-tyrosine dephosphorylation; IMP:EcoCyc. # GOslim_function GO:0016791 phosphatase activity # GOslim_process GO:0006464 cellular protein modification process # InterPro IPR017867 Tyr_phospatase_low_mol_wt # InterPro IPR023485 Ptyr_pPase_SF # KEGG_Brite ko01000 Enzymes # Organism ETP_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11717:SF20 PTHR11717:SF20 # PATRIC 32117187 VBIEscCol129921_1017 # PIR D64839 D64839 # PRINTS PR00719 LMWPTPASE # Pfam PF01451 LMWPc # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ETP_ECOLI Low molecular weight protein-tyrosine-phosphatase Etp # RefSeq NP_415502 NC_000913.3 # RefSeq WP_000057871 NZ_LN832404.1 # SIMILARITY Belongs to the low molecular weight phosphotyrosine protein phosphatase family. {ECO 0000305}. # SMART SM00226 LMWPc # SUPFAM SSF52788 SSF52788 # eggNOG COG0394 LUCA # eggNOG ENOG4107ZF2 Bacteria BLAST swissprot:ETP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ETP_ECOLI BioCyc ECOL316407:JW5132-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5132-MONOMER BioCyc EcoCyc:G6503-MONOMER http://biocyc.org/getid?id=EcoCyc:G6503-MONOMER BioCyc MetaCyc:G6503-MONOMER http://biocyc.org/getid?id=MetaCyc:G6503-MONOMER COG COG0394 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0394 COG COG2365 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2365 DOI 10.1006/jmbi.2000.4217 http://dx.doi.org/10.1006/jmbi.2000.4217 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.3.48 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.48 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.3.48 http://enzyme.expasy.org/EC/3.1.3.48 EchoBASE EB3491 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3491 EcoGene EG13727 http://www.ecogene.org/geneInfo.php?eg_id=EG13727 EnsemblBacteria AAC74067 http://www.ensemblgenomes.org/id/AAC74067 EnsemblBacteria AAC74067 http://www.ensemblgenomes.org/id/AAC74067 EnsemblBacteria BAA35747 http://www.ensemblgenomes.org/id/BAA35747 EnsemblBacteria BAA35747 http://www.ensemblgenomes.org/id/BAA35747 EnsemblBacteria BAA35747 http://www.ensemblgenomes.org/id/BAA35747 EnsemblBacteria b0982 http://www.ensemblgenomes.org/id/b0982 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004725 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004725 GO_process GO:0035335 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035335 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GeneID 945236 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945236 HOGENOM HOG000273091 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000273091&db=HOGENOM6 InParanoid P0ACZ2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACZ2 IntEnz 3.1.3.48 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.48 InterPro IPR017867 http://www.ebi.ac.uk/interpro/entry/IPR017867 InterPro IPR023485 http://www.ebi.ac.uk/interpro/entry/IPR023485 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5132 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5132 KEGG_Gene eco:b0982 http://www.genome.jp/dbget-bin/www_bget?eco:b0982 KEGG_Orthology KO:K01104 http://www.genome.jp/dbget-bin/www_bget?KO:K01104 OMA LCVGNIC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LCVGNIC PANTHER PTHR11717:SF20 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11717:SF20 PRINTS PR00719 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00719 PSORT swissprot:ETP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ETP_ECOLI PSORT-B swissprot:ETP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ETP_ECOLI PSORT2 swissprot:ETP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ETP_ECOLI Pfam PF01451 http://pfam.xfam.org/family/PF01451 Phobius swissprot:ETP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ETP_ECOLI PhylomeDB P0ACZ2 http://phylomedb.org/?seqid=P0ACZ2 ProteinModelPortal P0ACZ2 http://www.proteinmodelportal.org/query/uniprot/P0ACZ2 PubMed 11090276 http://www.ncbi.nlm.nih.gov/pubmed/11090276 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415502 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415502 RefSeq WP_000057871 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000057871 SMART SM00226 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00226 SMR P0ACZ2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACZ2 STRING 511145.b0982 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0982&targetmode=cogs STRING COG0394 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0394&targetmode=cogs STRING COG2365 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2365&targetmode=cogs SUPFAM SSF52788 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52788 UniProtKB ETP_ECOLI http://www.uniprot.org/uniprot/ETP_ECOLI UniProtKB-AC P0ACZ2 http://www.uniprot.org/uniprot/P0ACZ2 charge swissprot:ETP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ETP_ECOLI eggNOG COG0394 http://eggnogapi.embl.de/nog_data/html/tree/COG0394 eggNOG ENOG4107ZF2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107ZF2 epestfind swissprot:ETP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ETP_ECOLI garnier swissprot:ETP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ETP_ECOLI helixturnhelix swissprot:ETP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ETP_ECOLI hmoment swissprot:ETP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ETP_ECOLI iep swissprot:ETP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ETP_ECOLI inforesidue swissprot:ETP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ETP_ECOLI octanol swissprot:ETP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ETP_ECOLI pepcoil swissprot:ETP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ETP_ECOLI pepdigest swissprot:ETP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ETP_ECOLI pepinfo swissprot:ETP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ETP_ECOLI pepnet swissprot:ETP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ETP_ECOLI pepstats swissprot:ETP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ETP_ECOLI pepwheel swissprot:ETP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ETP_ECOLI pepwindow swissprot:ETP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ETP_ECOLI sigcleave swissprot:ETP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ETP_ECOLI ## Database ID URL or Descriptions # AltName ABGA_ECOLI PABA-GLU hydrolase # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=60 uM for PABA-GLU (at pH 8.5) {ECO 0000269|PubMed:20190044}; # CDD cd05665 M20_Acy1_IAAspH_bact # COFACTOR ABGA_ECOLI Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 20190044}; # EcoGene EG13352 abgA # FUNCTION ABGA_ECOLI Component of the p-aminobenzoyl-glutamate hydrolase multicomponent enzyme system which catalyzes the cleavage of p- aminobenzoyl-glutamate (PABA-GLU) to form p-aminobenzoate (PABA) and glutamate. AbgAB does not degrade dipeptides and the physiological role of abgABT should be clarified. {ECO 0000269|PubMed 17307853, ECO 0000269|PubMed 20190044}. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_function GO:0046982 protein heterodimerization activity; IPI:EcoliWiki. # GO_function GO:0071713 para-aminobenzoyl-glutamate hydrolase activity; IDA:UniProtKB. # GO_process GO:0046657 folic acid catabolic process; IGI:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.30.70.360 -; 1. # INDUCTION Could be transcriptionally regulated by AbgR. {ECO:0000269|PubMed 9829935}. # INTERACTION ABGA_ECOLI P76052 abgB; NbExp=2; IntAct=EBI-9155452, EBI-1123629; # IntAct P77357 2 # InterPro IPR002933 Peptidase_M20 # InterPro IPR011650 Peptidase_M20_dimer # InterPro IPR017439 Amidohydrolase # InterPro IPR033845 AbgA # KEGG_Brite ko01002 Peptidases # Organism ABGA_ECOLI Escherichia coli (strain K12) # PATRIC 32117952 VBIEscCol129921_1396 # PIR E64883 E64883 # PIRSF PIRSF005962 Pept_M20D_amidohydro # Pfam PF01546 Peptidase_M20 # Pfam PF07687 M20_dimer # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ABGA_ECOLI p-aminobenzoyl-glutamate hydrolase subunit A # RefSeq NP_415854 NC_000913.3 # RefSeq WP_000444929 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase M20 family. {ECO 0000305}. # SUBUNIT Forms a heterodimer with AbgB. {ECO:0000269|PubMed 20190044}. # SUPFAM SSF55031 SSF55031 # TIGRFAMs TIGR01891 amidohydrolases # eggNOG COG1473 LUCA # eggNOG ENOG4105CH2 Bacteria BLAST swissprot:ABGA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ABGA_ECOLI BioCyc ECOL316407:JW5205-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5205-MONOMER BioCyc EcoCyc:G6670-MONOMER http://biocyc.org/getid?id=EcoCyc:G6670-MONOMER BioCyc MetaCyc:G6670-MONOMER http://biocyc.org/getid?id=MetaCyc:G6670-MONOMER COG COG1473 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1473 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01362-09 http://dx.doi.org/10.1128/JB.01362-09 DOI 10.1128/JB.01940-06 http://dx.doi.org/10.1128/JB.01940-06 EC_number EC:3.5.1.- http://www.genome.jp/dbget-bin/www_bget?EC:3.5.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.5.1.- http://enzyme.expasy.org/EC/3.5.1.- EchoBASE EB3135 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3135 EcoGene EG13352 http://www.ecogene.org/geneInfo.php?eg_id=EG13352 EnsemblBacteria AAC74420 http://www.ensemblgenomes.org/id/AAC74420 EnsemblBacteria AAC74420 http://www.ensemblgenomes.org/id/AAC74420 EnsemblBacteria BAA14940 http://www.ensemblgenomes.org/id/BAA14940 EnsemblBacteria BAA14940 http://www.ensemblgenomes.org/id/BAA14940 EnsemblBacteria BAA14940 http://www.ensemblgenomes.org/id/BAA14940 EnsemblBacteria b1338 http://www.ensemblgenomes.org/id/b1338 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0046982 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046982 GO_function GO:0071713 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071713 GO_process GO:0046657 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046657 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.30.70.360 http://www.cathdb.info/version/latest/superfamily/3.30.70.360 GeneID 945742 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945742 HOGENOM HOG000241405 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000241405&db=HOGENOM6 InParanoid P77357 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77357 IntAct P77357 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77357* IntEnz 3.5.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.1 InterPro IPR002933 http://www.ebi.ac.uk/interpro/entry/IPR002933 InterPro IPR011650 http://www.ebi.ac.uk/interpro/entry/IPR011650 InterPro IPR017439 http://www.ebi.ac.uk/interpro/entry/IPR017439 InterPro IPR033845 http://www.ebi.ac.uk/interpro/entry/IPR033845 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW5205 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5205 KEGG_Gene eco:b1338 http://www.genome.jp/dbget-bin/www_bget?eco:b1338 KEGG_Orthology KO:K12940 http://www.genome.jp/dbget-bin/www_bget?KO:K12940 OMA TKIDIRY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TKIDIRY PSORT swissprot:ABGA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ABGA_ECOLI PSORT-B swissprot:ABGA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ABGA_ECOLI PSORT2 swissprot:ABGA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ABGA_ECOLI Pfam PF01546 http://pfam.xfam.org/family/PF01546 Pfam PF07687 http://pfam.xfam.org/family/PF07687 Phobius swissprot:ABGA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ABGA_ECOLI PhylomeDB P77357 http://phylomedb.org/?seqid=P77357 ProteinModelPortal P77357 http://www.proteinmodelportal.org/query/uniprot/P77357 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17307853 http://www.ncbi.nlm.nih.gov/pubmed/17307853 PubMed 20190044 http://www.ncbi.nlm.nih.gov/pubmed/20190044 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9829935 http://www.ncbi.nlm.nih.gov/pubmed/9829935 RefSeq NP_415854 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415854 RefSeq WP_000444929 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000444929 SMR P77357 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77357 STRING 511145.b1338 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1338&targetmode=cogs STRING COG1473 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1473&targetmode=cogs SUPFAM SSF55031 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55031 TIGRFAMs TIGR01891 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01891 UniProtKB ABGA_ECOLI http://www.uniprot.org/uniprot/ABGA_ECOLI UniProtKB-AC P77357 http://www.uniprot.org/uniprot/P77357 charge swissprot:ABGA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ABGA_ECOLI eggNOG COG1473 http://eggnogapi.embl.de/nog_data/html/tree/COG1473 eggNOG ENOG4105CH2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CH2 epestfind swissprot:ABGA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ABGA_ECOLI garnier swissprot:ABGA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ABGA_ECOLI helixturnhelix swissprot:ABGA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ABGA_ECOLI hmoment swissprot:ABGA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ABGA_ECOLI iep swissprot:ABGA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ABGA_ECOLI inforesidue swissprot:ABGA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ABGA_ECOLI octanol swissprot:ABGA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ABGA_ECOLI pepcoil swissprot:ABGA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ABGA_ECOLI pepdigest swissprot:ABGA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ABGA_ECOLI pepinfo swissprot:ABGA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ABGA_ECOLI pepnet swissprot:ABGA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ABGA_ECOLI pepstats swissprot:ABGA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ABGA_ECOLI pepwheel swissprot:ABGA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ABGA_ECOLI pepwindow swissprot:ABGA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ABGA_ECOLI sigcleave swissprot:ABGA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ABGA_ECOLI ## Database ID URL or Descriptions # AltName NANA_ECOLI N-acetylneuraminate pyruvate-lyase # AltName NANA_ECOLI N-acetylneuraminic acid aldolase # AltName NANA_ECOLI NALase # AltName NANA_ECOLI Sialate lyase # AltName NANA_ECOLI Sialic acid aldolase # AltName NANA_ECOLI Sialic acid lyase # BIOPHYSICOCHEMICAL PROPERTIES pH dependence: Optimum pH is 6.5-7.0.; Temperature dependence Optimum temperature is 80 degrees Celsius.; # BRENDA 4.1.3 2026 # BioGrid 4262442 341 # CATALYTIC ACTIVITY NANA_ECOLI N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate. # CDD cd00954 NAL # ENZYME REGULATION NANA_ECOLI Inhibited by reduction with NaBH(4), and by Cu(2+) ions, p-chloromercuribenzoate and N-bromosuccinimide. # EcoGene EG10637 nanA # FUNCTION NANA_ECOLI Catalyzes the reversible aldol cleavage of N- acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008747 N-acetylneuraminate lyase activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0005975 carbohydrate metabolic process; IEA:UniProtKB-HAMAP. # GO_process GO:0019262 N-acetylneuraminate catabolic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.70 -; 1. # HAMAP MF_01237 N_acetylneuram_lyase # INDUCTION NANA_ECOLI By N-acetylneuraminate. # IntAct P0A6L4 5 # InterPro IPR002220 DapA-like # InterPro IPR005264 NanA # InterPro IPR013785 Aldolase_TIM # InterPro IPR020624 Schiff_base-form_aldolases_CS # InterPro IPR020625 Schiff_base-form_aldolases_AS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00520 Amino sugar and nucleotide sugar metabolism # Organism NANA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR12128 PTHR12128 # PATHWAY Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate step 1/5. # PATRIC 32121874 VBIEscCol129921_3321 # PDB 1FDY X-ray; 2.45 A; A/B/C/D=1-297 # PDB 1FDZ X-ray; 2.60 A; A/B/C/D=1-297 # PDB 1HL2 X-ray; 1.80 A; A/B/C/D=1-297 # PDB 1NAL X-ray; 2.20 A; 1/2/3/4=1-297 # PDB 2WKJ X-ray; 1.45 A; A/B/C/D=2-296 # PDB 2WNN X-ray; 1.65 A; A/B/C/D=2-296 # PDB 2WNQ X-ray; 1.80 A; A/B/C/D=2-297 # PDB 2WNZ X-ray; 1.85 A; A/B/C/D=2-297 # PDB 2WO5 X-ray; 2.20 A; A/B/C/D=2-297 # PDB 2WPB X-ray; 2.05 A; A/B/C/D=2-297 # PDB 2XFW X-ray; 1.65 A; A/B/C/D=2-297 # PDB 2YGY X-ray; 1.90 A; A/B/C/D=2-297 # PDB 3LBC X-ray; 1.85 A; A/B/C/D=1-297 # PDB 3LBM X-ray; 1.48 A; A/B/C/D=1-297 # PDB 3LCF X-ray; 1.86 A; A/B/C/D=1-297 # PDB 3LCG X-ray; 1.78 A; A/B/C/D=1-297 # PDB 3LCH X-ray; 2.04 A; A/B/C/D=1-297 # PDB 3LCI X-ray; 2.12 A; A/B/C/D=1-297 # PDB 3LCL X-ray; 1.83 A; A/B/C/D=1-297 # PDB 3LCW X-ray; 2.35 A; A/B/C/D=1-297 # PDB 3LCX X-ray; 1.98 A; A/B/C/D=1-297 # PDB 4BWL X-ray; 2.00 A; A/B/C/D=2-297 # PDB 4UUI X-ray; 1.79 A; A/B/C/D=2-297 # PIR JP0002 WZECN # PIRSF PIRSF001365 DHDPS # PRINTS PR00146 DHPICSNTHASE # PROSITE PS00665 DHDPS_1 # PROSITE PS00666 DHDPS_2 # Pfam PF00701 DHDPS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NANA_ECOLI N-acetylneuraminate lyase # RefSeq NP_417692 NC_000913.3 # RefSeq WP_000224714 NZ_LN832404.1 # SIMILARITY Belongs to the DapA family. NanA subfamily. {ECO 0000305}. # SMART SM01130 DHDPS # SUBCELLULAR LOCATION NANA_ECOLI Cytoplasm. # SUBUNIT Homotetramer. {ECO:0000269|PubMed 8081752}. # TIGRFAMs TIGR00683 nanA # UniPathway UPA00629 UER00680 # eggNOG COG0329 LUCA # eggNOG ENOG4105CDP Bacteria BLAST swissprot:NANA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NANA_ECOLI BioCyc ECOL316407:JW3194-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3194-MONOMER BioCyc EcoCyc:ACNEULY-MONOMER http://biocyc.org/getid?id=EcoCyc:ACNEULY-MONOMER BioCyc MetaCyc:ACNEULY-MONOMER http://biocyc.org/getid?id=MetaCyc:ACNEULY-MONOMER COG COG0329 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0329 DIP DIP-10302N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10302N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/jmbi.1996.0769 http://dx.doi.org/10.1006/jmbi.1996.0769 DOI 10.1016/S0969-2126(00)00038-1 http://dx.doi.org/10.1016/S0969-2126(00)00038-1 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2760541 http://dx.doi.org/10.1042/bj2760541 DOI 10.1093/nar/13.24.8843 http://dx.doi.org/10.1093/nar/13.24.8843 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.1.3.3 http://www.genome.jp/dbget-bin/www_bget?EC:4.1.3.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D00067 http://www.ebi.ac.uk/ena/data/view/D00067 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X03345 http://www.ebi.ac.uk/ena/data/view/X03345 ENZYME 4.1.3.3 http://enzyme.expasy.org/EC/4.1.3.3 EchoBASE EB0631 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0631 EcoGene EG10637 http://www.ecogene.org/geneInfo.php?eg_id=EG10637 EnsemblBacteria AAC76257 http://www.ensemblgenomes.org/id/AAC76257 EnsemblBacteria AAC76257 http://www.ensemblgenomes.org/id/AAC76257 EnsemblBacteria BAE77268 http://www.ensemblgenomes.org/id/BAE77268 EnsemblBacteria BAE77268 http://www.ensemblgenomes.org/id/BAE77268 EnsemblBacteria BAE77268 http://www.ensemblgenomes.org/id/BAE77268 EnsemblBacteria b3225 http://www.ensemblgenomes.org/id/b3225 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008747 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008747 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GO_process GO:0019262 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019262 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 947742 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947742 HAMAP MF_01237 http://hamap.expasy.org/unirule/MF_01237 HOGENOM HOG000173608 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000173608&db=HOGENOM6 InParanoid P0A6L4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6L4 IntAct P0A6L4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6L4* IntEnz 4.1.3.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.3.3 InterPro IPR002220 http://www.ebi.ac.uk/interpro/entry/IPR002220 InterPro IPR005264 http://www.ebi.ac.uk/interpro/entry/IPR005264 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR020624 http://www.ebi.ac.uk/interpro/entry/IPR020624 InterPro IPR020625 http://www.ebi.ac.uk/interpro/entry/IPR020625 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3194 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3194 KEGG_Gene eco:b3225 http://www.genome.jp/dbget-bin/www_bget?eco:b3225 KEGG_Orthology KO:K01639 http://www.genome.jp/dbget-bin/www_bget?KO:K01639 KEGG_Pathway ko00520 http://www.genome.jp/kegg-bin/show_pathway?ko00520 KEGG_Reaction rn:R01811 http://www.genome.jp/dbget-bin/www_bget?rn:R01811 OMA DVPWLAQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DVPWLAQ PANTHER PTHR12128 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12128 PDB 1FDY http://www.ebi.ac.uk/pdbe-srv/view/entry/1FDY PDB 1FDZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1FDZ PDB 1HL2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1HL2 PDB 1NAL http://www.ebi.ac.uk/pdbe-srv/view/entry/1NAL PDB 2WKJ http://www.ebi.ac.uk/pdbe-srv/view/entry/2WKJ PDB 2WNN http://www.ebi.ac.uk/pdbe-srv/view/entry/2WNN PDB 2WNQ http://www.ebi.ac.uk/pdbe-srv/view/entry/2WNQ PDB 2WNZ http://www.ebi.ac.uk/pdbe-srv/view/entry/2WNZ PDB 2WO5 http://www.ebi.ac.uk/pdbe-srv/view/entry/2WO5 PDB 2WPB http://www.ebi.ac.uk/pdbe-srv/view/entry/2WPB PDB 2XFW http://www.ebi.ac.uk/pdbe-srv/view/entry/2XFW PDB 2YGY http://www.ebi.ac.uk/pdbe-srv/view/entry/2YGY PDB 3LBC http://www.ebi.ac.uk/pdbe-srv/view/entry/3LBC PDB 3LBM http://www.ebi.ac.uk/pdbe-srv/view/entry/3LBM PDB 3LCF http://www.ebi.ac.uk/pdbe-srv/view/entry/3LCF PDB 3LCG http://www.ebi.ac.uk/pdbe-srv/view/entry/3LCG PDB 3LCH http://www.ebi.ac.uk/pdbe-srv/view/entry/3LCH PDB 3LCI http://www.ebi.ac.uk/pdbe-srv/view/entry/3LCI PDB 3LCL http://www.ebi.ac.uk/pdbe-srv/view/entry/3LCL PDB 3LCW http://www.ebi.ac.uk/pdbe-srv/view/entry/3LCW PDB 3LCX http://www.ebi.ac.uk/pdbe-srv/view/entry/3LCX PDB 4BWL http://www.ebi.ac.uk/pdbe-srv/view/entry/4BWL PDB 4UUI http://www.ebi.ac.uk/pdbe-srv/view/entry/4UUI PDBsum 1FDY http://www.ebi.ac.uk/pdbsum/1FDY PDBsum 1FDZ http://www.ebi.ac.uk/pdbsum/1FDZ PDBsum 1HL2 http://www.ebi.ac.uk/pdbsum/1HL2 PDBsum 1NAL http://www.ebi.ac.uk/pdbsum/1NAL PDBsum 2WKJ http://www.ebi.ac.uk/pdbsum/2WKJ PDBsum 2WNN http://www.ebi.ac.uk/pdbsum/2WNN PDBsum 2WNQ http://www.ebi.ac.uk/pdbsum/2WNQ PDBsum 2WNZ http://www.ebi.ac.uk/pdbsum/2WNZ PDBsum 2WO5 http://www.ebi.ac.uk/pdbsum/2WO5 PDBsum 2WPB http://www.ebi.ac.uk/pdbsum/2WPB PDBsum 2XFW http://www.ebi.ac.uk/pdbsum/2XFW PDBsum 2YGY http://www.ebi.ac.uk/pdbsum/2YGY PDBsum 3LBC http://www.ebi.ac.uk/pdbsum/3LBC PDBsum 3LBM http://www.ebi.ac.uk/pdbsum/3LBM PDBsum 3LCF http://www.ebi.ac.uk/pdbsum/3LCF PDBsum 3LCG http://www.ebi.ac.uk/pdbsum/3LCG PDBsum 3LCH http://www.ebi.ac.uk/pdbsum/3LCH PDBsum 3LCI http://www.ebi.ac.uk/pdbsum/3LCI PDBsum 3LCL http://www.ebi.ac.uk/pdbsum/3LCL PDBsum 3LCW http://www.ebi.ac.uk/pdbsum/3LCW PDBsum 3LCX http://www.ebi.ac.uk/pdbsum/3LCX PDBsum 4BWL http://www.ebi.ac.uk/pdbsum/4BWL PDBsum 4UUI http://www.ebi.ac.uk/pdbsum/4UUI PRINTS PR00146 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00146 PROSITE PS00665 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00665 PROSITE PS00666 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00666 PSORT swissprot:NANA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NANA_ECOLI PSORT-B swissprot:NANA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NANA_ECOLI PSORT2 swissprot:NANA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NANA_ECOLI Pfam PF00701 http://pfam.xfam.org/family/PF00701 Phobius swissprot:NANA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NANA_ECOLI PhylomeDB P0A6L4 http://phylomedb.org/?seqid=P0A6L4 ProteinModelPortal P0A6L4 http://www.proteinmodelportal.org/query/uniprot/P0A6L4 PubMed 1646603 http://www.ncbi.nlm.nih.gov/pubmed/1646603 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3909108 http://www.ncbi.nlm.nih.gov/pubmed/3909108 PubMed 8081752 http://www.ncbi.nlm.nih.gov/pubmed/8081752 PubMed 9047371 http://www.ncbi.nlm.nih.gov/pubmed/9047371 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417692 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417692 RefSeq WP_000224714 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000224714 SMART SM01130 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01130 SMR P0A6L4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6L4 STRING 511145.b3225 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3225&targetmode=cogs STRING COG0329 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0329&targetmode=cogs TIGRFAMs TIGR00683 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00683 UniProtKB NANA_ECOLI http://www.uniprot.org/uniprot/NANA_ECOLI UniProtKB-AC P0A6L4 http://www.uniprot.org/uniprot/P0A6L4 charge swissprot:NANA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NANA_ECOLI eggNOG COG0329 http://eggnogapi.embl.de/nog_data/html/tree/COG0329 eggNOG ENOG4105CDP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CDP epestfind swissprot:NANA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NANA_ECOLI garnier swissprot:NANA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NANA_ECOLI helixturnhelix swissprot:NANA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NANA_ECOLI hmoment swissprot:NANA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NANA_ECOLI iep swissprot:NANA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NANA_ECOLI inforesidue swissprot:NANA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NANA_ECOLI octanol swissprot:NANA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NANA_ECOLI pepcoil swissprot:NANA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NANA_ECOLI pepdigest swissprot:NANA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NANA_ECOLI pepinfo swissprot:NANA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NANA_ECOLI pepnet swissprot:NANA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NANA_ECOLI pepstats swissprot:NANA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NANA_ECOLI pepwheel swissprot:NANA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NANA_ECOLI pepwindow swissprot:NANA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NANA_ECOLI sigcleave swissprot:NANA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NANA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260507 14 # EcoGene EG13184 elaA # GO_component GO:0031248 protein acetyltransferase complex; IBA:GO_Central. # GO_function GO:0004596 peptide alpha-N-acetyltransferase activity; IBA:GO_Central. # GO_process GO:0006474 N-terminal protein amino acid acetylation; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0006464 cellular protein modification process # Gene3D 3.40.630.30 -; 1. # IntAct P0AEH3 5 # InterPro IPR000182 GNAT_dom # InterPro IPR016181 Acyl_CoA_acyltransferase # Organism ELAA_ECOLI Escherichia coli (strain K12) # PATRIC 32119901 VBIEscCol129921_2360 # PIR A64998 A64998 # PROSITE PS51186 GNAT # Pfam PF13673 Acetyltransf_10 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ELAA_ECOLI Protein ElaA # RefSeq NP_416770 NC_000913.3 # RefSeq WP_000574091 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0039 (ElaA) family. {ECO 0000305}. # SIMILARITY Contains 1 N-acetyltransferase domain. {ECO:0000255|PROSITE-ProRule PRU00532}. # SUPFAM SSF55729 SSF55729 # eggNOG COG2153 LUCA # eggNOG ENOG4107YB6 Bacteria BLAST swissprot:ELAA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ELAA_ECOLI BioCyc ECOL316407:JW2262-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2262-MONOMER BioCyc EcoCyc:G7174-MONOMER http://biocyc.org/getid?id=EcoCyc:G7174-MONOMER COG COG2153 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2153 DOI 10.1016/0014-5793(95)01436-5 http://dx.doi.org/10.1016/0014-5793(95)01436-5 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U58768 http://www.ebi.ac.uk/ena/data/view/U58768 EMBL Z50849 http://www.ebi.ac.uk/ena/data/view/Z50849 EchoBASE EB2976 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2976 EcoGene EG13184 http://www.ecogene.org/geneInfo.php?eg_id=EG13184 EnsemblBacteria AAC75327 http://www.ensemblgenomes.org/id/AAC75327 EnsemblBacteria AAC75327 http://www.ensemblgenomes.org/id/AAC75327 EnsemblBacteria BAA16094 http://www.ensemblgenomes.org/id/BAA16094 EnsemblBacteria BAA16094 http://www.ensemblgenomes.org/id/BAA16094 EnsemblBacteria BAA16094 http://www.ensemblgenomes.org/id/BAA16094 EnsemblBacteria b2267 http://www.ensemblgenomes.org/id/b2267 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0031248 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031248 GO_function GO:0004596 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004596 GO_process GO:0006474 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006474 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 Gene3D 3.40.630.30 http://www.cathdb.info/version/latest/superfamily/3.40.630.30 GeneID 946750 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946750 HOGENOM HOG000276481 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276481&db=HOGENOM6 InParanoid P0AEH3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEH3 IntAct P0AEH3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEH3* InterPro IPR000182 http://www.ebi.ac.uk/interpro/entry/IPR000182 InterPro IPR016181 http://www.ebi.ac.uk/interpro/entry/IPR016181 KEGG_Gene ecj:JW2262 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2262 KEGG_Gene eco:b2267 http://www.genome.jp/dbget-bin/www_bget?eco:b2267 KEGG_Orthology KO:K02348 http://www.genome.jp/dbget-bin/www_bget?KO:K02348 OMA HLQGFYG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HLQGFYG PROSITE PS51186 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51186 PSORT swissprot:ELAA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ELAA_ECOLI PSORT-B swissprot:ELAA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ELAA_ECOLI PSORT2 swissprot:ELAA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ELAA_ECOLI Pfam PF13673 http://pfam.xfam.org/family/PF13673 Phobius swissprot:ELAA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ELAA_ECOLI PhylomeDB P0AEH3 http://phylomedb.org/?seqid=P0AEH3 ProteinModelPortal P0AEH3 http://www.proteinmodelportal.org/query/uniprot/P0AEH3 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8549818 http://www.ncbi.nlm.nih.gov/pubmed/8549818 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416770 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416770 RefSeq WP_000574091 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000574091 SMR P0AEH3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEH3 STRING 511145.b2267 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2267&targetmode=cogs STRING COG2153 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2153&targetmode=cogs SUPFAM SSF55729 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55729 UniProtKB ELAA_ECOLI http://www.uniprot.org/uniprot/ELAA_ECOLI UniProtKB-AC P0AEH3 http://www.uniprot.org/uniprot/P0AEH3 charge swissprot:ELAA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ELAA_ECOLI eggNOG COG2153 http://eggnogapi.embl.de/nog_data/html/tree/COG2153 eggNOG ENOG4107YB6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107YB6 epestfind swissprot:ELAA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ELAA_ECOLI garnier swissprot:ELAA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ELAA_ECOLI helixturnhelix swissprot:ELAA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ELAA_ECOLI hmoment swissprot:ELAA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ELAA_ECOLI iep swissprot:ELAA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ELAA_ECOLI inforesidue swissprot:ELAA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ELAA_ECOLI octanol swissprot:ELAA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ELAA_ECOLI pepcoil swissprot:ELAA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ELAA_ECOLI pepdigest swissprot:ELAA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ELAA_ECOLI pepinfo swissprot:ELAA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ELAA_ECOLI pepnet swissprot:ELAA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ELAA_ECOLI pepstats swissprot:ELAA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ELAA_ECOLI pepwheel swissprot:ELAA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ELAA_ECOLI pepwindow swissprot:ELAA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ELAA_ECOLI sigcleave swissprot:ELAA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ELAA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259260 11 # CAUTION Lacks the conserved His residues required for metal binding. Its function must therefore be different from the metal- dependent roles proposed for other family members. {ECO 0000305}. # EcoGene EG12750 yhaK # FUNCTION YHAK_ECOLI Does not have quercetin 2,3-dioxygenase activity. {ECO 0000269|PubMed 18561187}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GOslim_component GO:0005737 cytoplasm # Gene3D 2.60.120.10 -; 1. # IntAct P42624 12 # InterPro IPR003829 Pirin_N_dom # InterPro IPR011051 RmlC_Cupin # InterPro IPR012093 Pirin # InterPro IPR014710 RmlC-like_jellyroll # MISCELLANEOUS YHAK_ECOLI Contains Cys residues that are easily oxidized. # Organism YHAK_ECOLI Escherichia coli (strain K12) # PANTHER PTHR13903 PTHR13903 # PATRIC 32121632 VBIEscCol129921_3202 # PDB 2VEC X-ray; 1.85 A; A=2-233 # PIR G65099 G65099 # PIRSF PIRSF006232 Pirin # Pfam PF02678 Pirin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHAK_ECOLI Pirin-like protein YhaK # RefSeq NP_417577 NC_000913.3 # RefSeq WP_000633576 NZ_LN832404.1 # SIMILARITY Belongs to the pirin family. {ECO 0000305}. # SUBCELLULAR LOCATION YHAK_ECOLI Cytoplasm {ECO 0000305|PubMed 18561187}. # SUBUNIT Monomer. {ECO:0000269|PubMed 18561187}. # SUPFAM SSF51182 SSF51182 # eggNOG COG1741 LUCA # eggNOG ENOG4108CNN Bacteria BLAST swissprot:YHAK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHAK_ECOLI BioCyc ECOL316407:JW3077-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3077-MONOMER BioCyc EcoCyc:G7620-MONOMER http://biocyc.org/getid?id=EcoCyc:G7620-MONOMER COG COG1741 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1741 DOI 10.1002/prot.22128 http://dx.doi.org/10.1002/prot.22128 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2606 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2606 EcoGene EG12750 http://www.ecogene.org/geneInfo.php?eg_id=EG12750 EnsemblBacteria AAC76141 http://www.ensemblgenomes.org/id/AAC76141 EnsemblBacteria AAC76141 http://www.ensemblgenomes.org/id/AAC76141 EnsemblBacteria BAE77156 http://www.ensemblgenomes.org/id/BAE77156 EnsemblBacteria BAE77156 http://www.ensemblgenomes.org/id/BAE77156 EnsemblBacteria BAE77156 http://www.ensemblgenomes.org/id/BAE77156 EnsemblBacteria b3106 http://www.ensemblgenomes.org/id/b3106 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 Gene3D 2.60.120.10 http://www.cathdb.info/version/latest/superfamily/2.60.120.10 GeneID 947620 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947620 HOGENOM HOG000114206 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000114206&db=HOGENOM6 InParanoid P42624 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P42624 IntAct P42624 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P42624* InterPro IPR003829 http://www.ebi.ac.uk/interpro/entry/IPR003829 InterPro IPR011051 http://www.ebi.ac.uk/interpro/entry/IPR011051 InterPro IPR012093 http://www.ebi.ac.uk/interpro/entry/IPR012093 InterPro IPR014710 http://www.ebi.ac.uk/interpro/entry/IPR014710 KEGG_Gene ecj:JW3077 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3077 KEGG_Gene eco:b3106 http://www.genome.jp/dbget-bin/www_bget?eco:b3106 KEGG_Orthology KO:K06911 http://www.genome.jp/dbget-bin/www_bget?KO:K06911 OMA TQPGISY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TQPGISY PANTHER PTHR13903 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13903 PDB 2VEC http://www.ebi.ac.uk/pdbe-srv/view/entry/2VEC PDBsum 2VEC http://www.ebi.ac.uk/pdbsum/2VEC PSORT swissprot:YHAK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHAK_ECOLI PSORT-B swissprot:YHAK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHAK_ECOLI PSORT2 swissprot:YHAK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHAK_ECOLI Pfam PF02678 http://pfam.xfam.org/family/PF02678 Phobius swissprot:YHAK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHAK_ECOLI PhylomeDB P42624 http://phylomedb.org/?seqid=P42624 ProteinModelPortal P42624 http://www.proteinmodelportal.org/query/uniprot/P42624 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18561187 http://www.ncbi.nlm.nih.gov/pubmed/18561187 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417577 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417577 RefSeq WP_000633576 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000633576 SMR P42624 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P42624 STRING 511145.b3106 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3106&targetmode=cogs STRING COG1741 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1741&targetmode=cogs SUPFAM SSF51182 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51182 UniProtKB YHAK_ECOLI http://www.uniprot.org/uniprot/YHAK_ECOLI UniProtKB-AC P42624 http://www.uniprot.org/uniprot/P42624 charge swissprot:YHAK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHAK_ECOLI eggNOG COG1741 http://eggnogapi.embl.de/nog_data/html/tree/COG1741 eggNOG ENOG4108CNN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108CNN epestfind swissprot:YHAK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHAK_ECOLI garnier swissprot:YHAK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHAK_ECOLI helixturnhelix swissprot:YHAK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHAK_ECOLI hmoment swissprot:YHAK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHAK_ECOLI iep swissprot:YHAK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHAK_ECOLI inforesidue swissprot:YHAK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHAK_ECOLI octanol swissprot:YHAK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHAK_ECOLI pepcoil swissprot:YHAK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHAK_ECOLI pepdigest swissprot:YHAK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHAK_ECOLI pepinfo swissprot:YHAK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHAK_ECOLI pepnet swissprot:YHAK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHAK_ECOLI pepstats swissprot:YHAK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHAK_ECOLI pepwheel swissprot:YHAK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHAK_ECOLI pepwindow swissprot:YHAK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHAK_ECOLI sigcleave swissprot:YHAK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHAK_ECOLI ## Database ID URL or Descriptions # BioGrid 4262582 25 # CDD cd06174 MFS # EcoGene EG11053 uhpC # FUNCTION UHPC_ECOLI Part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC senses external glucose-6-phosphate and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. {ECO 0000269|PubMed 11053370, ECO 0000269|PubMed 11739766, ECO 0000269|PubMed 3038843, ECO 0000269|PubMed 8349544}. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_component GO:0005886 plasma membrane; IDA:EcoliWiki. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:EcoliWiki. # GO_component GO:0031226 intrinsic component of plasma membrane; IDA:EcoliWiki. # GO_function GO:0022857 transmembrane transporter activity; IBA:GO_Central. # GO_process GO:0000160 phosphorelay signal transduction system; IMP:EcoCyc. # GO_process GO:0006820 anion transport; IBA:GO_Central. # GO_process GO:0055085 transmembrane transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005622 intracellular # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0055085 transmembrane transport # InterPro IPR000849 Sugar_P_transporter # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # InterPro IPR021159 Sugar-P_transporter_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02020 Two-component system # Organism UHPC_ECOLI Escherichia coli (strain K12) # PATRIC 32122827 VBIEscCol129921_3789 # PIR D65168 RGECUC # PIRSF PIRSF002808 Hexose_phosphate_transp # PROSITE PS00942 GLPT # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Membrane sensor protein UhpC {ECO 0000305} # RefSeq NP_418123 NC_000913.3 # RefSeq WP_000936566 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA24722.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAA62019.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family. {ECO 0000305}. # SUBCELLULAR LOCATION UHPC_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255}. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.4 the major facilitator superfamily (mfs) # eggNOG COG2271 LUCA # eggNOG ENOG4105CXY Bacteria BLAST swissprot:UHPC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UHPC_ECOLI BioCyc ECOL316407:JW3642-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3642-MONOMER BioCyc EcoCyc:UHPC-MONOMER http://biocyc.org/getid?id=EcoCyc:UHPC-MONOMER COG COG2271 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2271 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1099/00221287-147-12-3345 http://dx.doi.org/10.1099/00221287-147-12-3345 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.22.6279-6286.2000 http://dx.doi.org/10.1128/JB.182.22.6279-6286.2000 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M17102 http://www.ebi.ac.uk/ena/data/view/M17102 EMBL M89479 http://www.ebi.ac.uk/ena/data/view/M89479 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1046 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1046 EcoGene EG11053 http://www.ecogene.org/geneInfo.php?eg_id=EG11053 EnsemblBacteria AAC76690 http://www.ensemblgenomes.org/id/AAC76690 EnsemblBacteria AAC76690 http://www.ensemblgenomes.org/id/AAC76690 EnsemblBacteria BAE77626 http://www.ensemblgenomes.org/id/BAE77626 EnsemblBacteria BAE77626 http://www.ensemblgenomes.org/id/BAE77626 EnsemblBacteria BAE77626 http://www.ensemblgenomes.org/id/BAE77626 EnsemblBacteria b3667 http://www.ensemblgenomes.org/id/b3667 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0031226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031226 GO_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006820 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006820 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 948184 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948184 HOGENOM HOG000274727 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000274727&db=HOGENOM6 InParanoid P09836 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P09836 InterPro IPR000849 http://www.ebi.ac.uk/interpro/entry/IPR000849 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 InterPro IPR021159 http://www.ebi.ac.uk/interpro/entry/IPR021159 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3642 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3642 KEGG_Gene eco:b3667 http://www.genome.jp/dbget-bin/www_bget?eco:b3667 KEGG_Orthology KO:K07783 http://www.genome.jp/dbget-bin/www_bget?KO:K07783 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA YIWLLAC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YIWLLAC PROSITE PS00942 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00942 PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:UHPC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UHPC_ECOLI PSORT-B swissprot:UHPC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UHPC_ECOLI PSORT2 swissprot:UHPC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UHPC_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:UHPC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UHPC_ECOLI PhylomeDB P09836 http://phylomedb.org/?seqid=P09836 ProteinModelPortal P09836 http://www.proteinmodelportal.org/query/uniprot/P09836 PubMed 11053370 http://www.ncbi.nlm.nih.gov/pubmed/11053370 PubMed 11739766 http://www.ncbi.nlm.nih.gov/pubmed/11739766 PubMed 1569007 http://www.ncbi.nlm.nih.gov/pubmed/1569007 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3038843 http://www.ncbi.nlm.nih.gov/pubmed/3038843 PubMed 3301805 http://www.ncbi.nlm.nih.gov/pubmed/3301805 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 8349544 http://www.ncbi.nlm.nih.gov/pubmed/8349544 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418123 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418123 RefSeq WP_000936566 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000936566 STRING 511145.b3667 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3667&targetmode=cogs STRING COG2271 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2271&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.4 http://www.tcdb.org/search/result.php?tc=2.A.1.4 UniProtKB UHPC_ECOLI http://www.uniprot.org/uniprot/UHPC_ECOLI UniProtKB-AC P09836 http://www.uniprot.org/uniprot/P09836 charge swissprot:UHPC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UHPC_ECOLI eggNOG COG2271 http://eggnogapi.embl.de/nog_data/html/tree/COG2271 eggNOG ENOG4105CXY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CXY epestfind swissprot:UHPC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UHPC_ECOLI garnier swissprot:UHPC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UHPC_ECOLI helixturnhelix swissprot:UHPC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UHPC_ECOLI hmoment swissprot:UHPC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UHPC_ECOLI iep swissprot:UHPC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UHPC_ECOLI inforesidue swissprot:UHPC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UHPC_ECOLI octanol swissprot:UHPC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UHPC_ECOLI pepcoil swissprot:UHPC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UHPC_ECOLI pepdigest swissprot:UHPC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UHPC_ECOLI pepinfo swissprot:UHPC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UHPC_ECOLI pepnet swissprot:UHPC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UHPC_ECOLI pepstats swissprot:UHPC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UHPC_ECOLI pepwheel swissprot:UHPC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UHPC_ECOLI pepwindow swissprot:UHPC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UHPC_ECOLI sigcleave swissprot:UHPC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UHPC_ECOLI ## Database ID URL or Descriptions # AltName YIAO_ECOLI Extracytoplasmic solute receptor protein YiaO # BioGrid 4262009 5 # CAUTION Was originally proposed to be a subunit from an L- xylulose uptake system, but PubMed:16385129 shows that YiaO does not bind L- or D-xylulose. {ECO 0000305|PubMed:14668138}. # EcoGene EG12283 yiaO # FUNCTION YIAO_ECOLI Part of the tripartite ATP-independent periplasmic (TRAP) transport system YiaMNO involved in the uptake of 2,3- diketo-L-gulonate. This protein specifically binds 2,3-diketo-L- gulonate. Is not able to bind either L-ascorbate or dehydroascorbate. {ECO 0000269|PubMed 16385129}. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IEA:InterPro. # GO_function GO:0030246 carbohydrate binding; IDA:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0034219 carbohydrate transmembrane transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006950 response to stress # GOslim_process GO:0055085 transmembrane transport # InterPro IPR004682 TRAP_DctP # InterPro IPR018389 TRAP_DctP/TeaA # MASS SPECTROMETRY Mass=33468.8; Mass_error=2; Method=Electrospray; Range=25-328; Evidence={ECO:0000269|PubMed 16385129}; # Organism YIAO_ECOLI Escherichia coli (strain K12) # PATRIC 32122634 VBIEscCol129921_3694 # PIR S47800 S47800 # PIRSF PIRSF006470 DctB # Pfam PF03480 DctP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIAO_ECOLI 2,3-diketo-L-gulonate-binding periplasmic protein YiaO # RefSeq NP_418036 NC_000913.3 # RefSeq WP_000776887 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial solute-binding protein 7 family. {ECO 0000305}. # SUBCELLULAR LOCATION YIAO_ECOLI Periplasm {ECO 0000269|PubMed 16385129}. # SUBUNIT YIAO_ECOLI The complex comprises the extracytoplasmic solute receptor protein YiaO, and the two transmembrane proteins YiaM and YiaN. # TCDB 2.A.56.1 the tripartite atp-independent periplasmic transporter (trap-t) family # TIGRFAMs TIGR00787 dctP # eggNOG COG1638 LUCA # eggNOG ENOG4105DR6 Bacteria BLAST swissprot:YIAO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIAO_ECOLI BioCyc ECOL316407:JW3551-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3551-MONOMER BioCyc EcoCyc:EG12283-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12283-MONOMER BioCyc MetaCyc:EG12283-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12283-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1080/09687680310001607369 http://dx.doi.org/10.1080/09687680310001607369 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1099/mic.0.27851-0 http://dx.doi.org/10.1099/mic.0.27851-0 DOI 10.1099/mic.0.28334-0 http://dx.doi.org/10.1099/mic.0.28334-0 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2191 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2191 EcoGene EG12283 http://www.ecogene.org/geneInfo.php?eg_id=EG12283 EnsemblBacteria AAC76603 http://www.ensemblgenomes.org/id/AAC76603 EnsemblBacteria AAC76603 http://www.ensemblgenomes.org/id/AAC76603 EnsemblBacteria BAE77714 http://www.ensemblgenomes.org/id/BAE77714 EnsemblBacteria BAE77714 http://www.ensemblgenomes.org/id/BAE77714 EnsemblBacteria BAE77714 http://www.ensemblgenomes.org/id/BAE77714 EnsemblBacteria b3579 http://www.ensemblgenomes.org/id/b3579 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0030246 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030246 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0034219 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034219 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 948091 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948091 HOGENOM HOG000251307 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000251307&db=HOGENOM6 InParanoid P37676 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37676 InterPro IPR004682 http://www.ebi.ac.uk/interpro/entry/IPR004682 InterPro IPR018389 http://www.ebi.ac.uk/interpro/entry/IPR018389 KEGG_Gene ecj:JW3551 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3551 KEGG_Gene eco:b3579 http://www.genome.jp/dbget-bin/www_bget?eco:b3579 OMA GQAADYF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GQAADYF PSORT swissprot:YIAO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIAO_ECOLI PSORT-B swissprot:YIAO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIAO_ECOLI PSORT2 swissprot:YIAO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIAO_ECOLI Pfam PF03480 http://pfam.xfam.org/family/PF03480 Phobius swissprot:YIAO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIAO_ECOLI PhylomeDB P37676 http://phylomedb.org/?seqid=P37676 ProteinModelPortal P37676 http://www.proteinmodelportal.org/query/uniprot/P37676 PubMed 14668138 http://www.ncbi.nlm.nih.gov/pubmed/14668138 PubMed 15870475 http://www.ncbi.nlm.nih.gov/pubmed/15870475 PubMed 16385129 http://www.ncbi.nlm.nih.gov/pubmed/16385129 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418036 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418036 RefSeq WP_000776887 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000776887 SMR P37676 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37676 STRING 511145.b3579 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3579&targetmode=cogs TCDB 2.A.56.1 http://www.tcdb.org/search/result.php?tc=2.A.56.1 TIGRFAMs TIGR00787 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00787 UniProtKB YIAO_ECOLI http://www.uniprot.org/uniprot/YIAO_ECOLI UniProtKB-AC P37676 http://www.uniprot.org/uniprot/P37676 charge swissprot:YIAO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIAO_ECOLI eggNOG COG1638 http://eggnogapi.embl.de/nog_data/html/tree/COG1638 eggNOG ENOG4105DR6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DR6 epestfind swissprot:YIAO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIAO_ECOLI garnier swissprot:YIAO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIAO_ECOLI helixturnhelix swissprot:YIAO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIAO_ECOLI hmoment swissprot:YIAO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIAO_ECOLI iep swissprot:YIAO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIAO_ECOLI inforesidue swissprot:YIAO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIAO_ECOLI octanol swissprot:YIAO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIAO_ECOLI pepcoil swissprot:YIAO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIAO_ECOLI pepdigest swissprot:YIAO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIAO_ECOLI pepinfo swissprot:YIAO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIAO_ECOLI pepnet swissprot:YIAO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIAO_ECOLI pepstats swissprot:YIAO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIAO_ECOLI pepwheel swissprot:YIAO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIAO_ECOLI pepwindow swissprot:YIAO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIAO_ECOLI sigcleave swissprot:YIAO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIAO_ECOLI ## Database ID URL or Descriptions # BioGrid 4259743 19 # DISRUPTION PHENOTYPE No visible phenotype. {ECO:0000269|PubMed 11272834}. # EcoGene EG10949 sfsA # FUNCTION SFSA_ECOLI Binds to DNA non-specifically. Could be a regulatory factor involved in maltose metabolism. {ECO 0000255|HAMAP- Rule MF_00095, ECO 0000269|PubMed 11272834, ECO 0000269|PubMed 2013578}. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IMP:EcoCyc. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # HAMAP MF_00095 SfsA # INTERACTION SFSA_ECOLI P0AFT5 yehT; NbExp=2; IntAct=EBI-556413, EBI-556431; # IntAct P0A823 7 # InterPro IPR005224 SfsA # Organism SFSA_ECOLI Escherichia coli (strain K12) # PATRIC 32115399 VBIEscCol129921_0151 # PDB 4DAP X-ray; 2.20 A; A=1-234 # PIR A43671 A43671 # Pfam PF03749 SfsA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Sugar fermentation stimulation protein A {ECO:0000255|HAMAP-Rule MF_00095} # RefSeq NP_414688 NC_000913.3 # RefSeq WP_000396036 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=M34945; Type=Frameshift; Positions=160; Evidence={ECO 0000305}; # SIMILARITY Belongs to the SfsA family. {ECO:0000255|HAMAP- Rule MF_00095}. # TIGRFAMs TIGR00230 sfsA # eggNOG COG1489 LUCA # eggNOG ENOG4105PW4 Bacteria BLAST swissprot:SFSA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SFSA_ECOLI BioCyc ECOL316407:JW0142-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0142-MONOMER BioCyc EcoCyc:EG10949-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10949-MONOMER COG COG1489 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1489 DIP DIP-48084N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48084N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1271/bbb.65.213 http://dx.doi.org/10.1271/bbb.65.213 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M34945 http://www.ebi.ac.uk/ena/data/view/M34945 EMBL M60726 http://www.ebi.ac.uk/ena/data/view/M60726 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0942 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0942 EcoGene EG10949 http://www.ecogene.org/geneInfo.php?eg_id=EG10949 EnsemblBacteria AAC73257 http://www.ensemblgenomes.org/id/AAC73257 EnsemblBacteria AAC73257 http://www.ensemblgenomes.org/id/AAC73257 EnsemblBacteria BAB96723 http://www.ensemblgenomes.org/id/BAB96723 EnsemblBacteria BAB96723 http://www.ensemblgenomes.org/id/BAB96723 EnsemblBacteria BAB96723 http://www.ensemblgenomes.org/id/BAB96723 EnsemblBacteria b0146 http://www.ensemblgenomes.org/id/b0146 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 944855 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944855 HAMAP MF_00095 http://hamap.expasy.org/unirule/MF_00095 HOGENOM HOG000218438 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218438&db=HOGENOM6 InParanoid P0A823 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A823 IntAct P0A823 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A823* InterPro IPR005224 http://www.ebi.ac.uk/interpro/entry/IPR005224 KEGG_Gene ecj:JW0142 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0142 KEGG_Gene eco:b0146 http://www.genome.jp/dbget-bin/www_bget?eco:b0146 KEGG_Orthology KO:K06206 http://www.genome.jp/dbget-bin/www_bget?KO:K06206 MINT MINT-1271616 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1271616 OMA MLYFINR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MLYFINR PDB 4DAP http://www.ebi.ac.uk/pdbe-srv/view/entry/4DAP PDBsum 4DAP http://www.ebi.ac.uk/pdbsum/4DAP PSORT swissprot:SFSA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SFSA_ECOLI PSORT-B swissprot:SFSA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SFSA_ECOLI PSORT2 swissprot:SFSA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SFSA_ECOLI Pfam PF03749 http://pfam.xfam.org/family/PF03749 Phobius swissprot:SFSA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SFSA_ECOLI PhylomeDB P0A823 http://phylomedb.org/?seqid=P0A823 ProteinModelPortal P0A823 http://www.proteinmodelportal.org/query/uniprot/P0A823 PubMed 11272834 http://www.ncbi.nlm.nih.gov/pubmed/11272834 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2013578 http://www.ncbi.nlm.nih.gov/pubmed/2013578 PubMed 2180916 http://www.ncbi.nlm.nih.gov/pubmed/2180916 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414688 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414688 RefSeq WP_000396036 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000396036 SMR P0A823 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A823 STRING 511145.b0146 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0146&targetmode=cogs STRING COG1489 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1489&targetmode=cogs TIGRFAMs TIGR00230 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00230 UniProtKB SFSA_ECOLI http://www.uniprot.org/uniprot/SFSA_ECOLI UniProtKB-AC P0A823 http://www.uniprot.org/uniprot/P0A823 charge swissprot:SFSA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SFSA_ECOLI eggNOG COG1489 http://eggnogapi.embl.de/nog_data/html/tree/COG1489 eggNOG ENOG4105PW4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105PW4 epestfind swissprot:SFSA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SFSA_ECOLI garnier swissprot:SFSA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SFSA_ECOLI helixturnhelix swissprot:SFSA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SFSA_ECOLI hmoment swissprot:SFSA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SFSA_ECOLI iep swissprot:SFSA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SFSA_ECOLI inforesidue swissprot:SFSA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SFSA_ECOLI octanol swissprot:SFSA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SFSA_ECOLI pepcoil swissprot:SFSA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SFSA_ECOLI pepdigest swissprot:SFSA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SFSA_ECOLI pepinfo swissprot:SFSA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SFSA_ECOLI pepnet swissprot:SFSA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SFSA_ECOLI pepstats swissprot:SFSA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SFSA_ECOLI pepwheel swissprot:SFSA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SFSA_ECOLI pepwindow swissprot:SFSA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SFSA_ECOLI sigcleave swissprot:SFSA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SFSA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261843 8 # EcoGene EG13664 ybhH # GO_function GO:0016853 isomerase activity; IEA:UniProtKB-KW. # GOslim_function GO:0016853 isomerase activity # InterPro IPR007400 PrpF_protein # Organism YBHH_ECOLI Escherichia coli (strain K12) # PATRIC 32116739 VBIEscCol129921_0795 # PIR A64813 A64813 # Pfam PF04303 PrpF # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBHH_ECOLI Putative isomerase YbhH # RefSeq NP_415290 NC_000913.3 # RefSeq WP_000723652 NZ_LN832404.1 # SIMILARITY Belongs to the PrpF family. {ECO 0000305}. # eggNOG COG2828 LUCA # eggNOG ENOG4105C7F Bacteria BLAST swissprot:YBHH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBHH_ECOLI BioCyc ECOL316407:JW0752-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0752-MONOMER BioCyc EcoCyc:G6399-MONOMER http://biocyc.org/getid?id=EcoCyc:G6399-MONOMER COG COG2828 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2828 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:5.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 5.-.-.- http://enzyme.expasy.org/EC/5.-.-.- EchoBASE EB3428 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3428 EcoGene EG13664 http://www.ecogene.org/geneInfo.php?eg_id=EG13664 EnsemblBacteria AAC73856 http://www.ensemblgenomes.org/id/AAC73856 EnsemblBacteria AAC73856 http://www.ensemblgenomes.org/id/AAC73856 EnsemblBacteria BAA35433 http://www.ensemblgenomes.org/id/BAA35433 EnsemblBacteria BAA35433 http://www.ensemblgenomes.org/id/BAA35433 EnsemblBacteria BAA35433 http://www.ensemblgenomes.org/id/BAA35433 EnsemblBacteria b0769 http://www.ensemblgenomes.org/id/b0769 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GeneID 945375 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945375 HOGENOM HOG000220028 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220028&db=HOGENOM6 InParanoid P0AAV8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAV8 IntEnz 5 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5 InterPro IPR007400 http://www.ebi.ac.uk/interpro/entry/IPR007400 KEGG_Gene ecj:JW0752 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0752 KEGG_Gene eco:b0769 http://www.genome.jp/dbget-bin/www_bget?eco:b0769 KEGG_Orthology KO:K09788 http://www.genome.jp/dbget-bin/www_bget?KO:K09788 OMA TLQVRYF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TLQVRYF PSORT swissprot:YBHH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBHH_ECOLI PSORT-B swissprot:YBHH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBHH_ECOLI PSORT2 swissprot:YBHH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBHH_ECOLI Pfam PF04303 http://pfam.xfam.org/family/PF04303 Phobius swissprot:YBHH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBHH_ECOLI PhylomeDB P0AAV8 http://phylomedb.org/?seqid=P0AAV8 ProteinModelPortal P0AAV8 http://www.proteinmodelportal.org/query/uniprot/P0AAV8 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415290 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415290 RefSeq WP_000723652 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000723652 SMR P0AAV8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAV8 STRING 511145.b0769 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0769&targetmode=cogs STRING COG2828 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2828&targetmode=cogs UniProtKB YBHH_ECOLI http://www.uniprot.org/uniprot/YBHH_ECOLI UniProtKB-AC P0AAV8 http://www.uniprot.org/uniprot/P0AAV8 charge swissprot:YBHH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBHH_ECOLI eggNOG COG2828 http://eggnogapi.embl.de/nog_data/html/tree/COG2828 eggNOG ENOG4105C7F http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C7F epestfind swissprot:YBHH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBHH_ECOLI garnier swissprot:YBHH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBHH_ECOLI helixturnhelix swissprot:YBHH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBHH_ECOLI hmoment swissprot:YBHH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBHH_ECOLI iep swissprot:YBHH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBHH_ECOLI inforesidue swissprot:YBHH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBHH_ECOLI octanol swissprot:YBHH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBHH_ECOLI pepcoil swissprot:YBHH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBHH_ECOLI pepdigest swissprot:YBHH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBHH_ECOLI pepinfo swissprot:YBHH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBHH_ECOLI pepnet swissprot:YBHH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBHH_ECOLI pepstats swissprot:YBHH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBHH_ECOLI pepwheel swissprot:YBHH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBHH_ECOLI pepwindow swissprot:YBHH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBHH_ECOLI sigcleave swissprot:YBHH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBHH_ECOLI ## Database ID URL or Descriptions # BioGrid 4261455 14 # CDD cd01948 EAL # EcoGene EG13888 ycgG # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005886 plasma membrane # Gene3D 3.20.20.450 -; 1. # INDUCTION Induced by 0.3 M NaCl in an RpoS-dependent fashion. {ECO:0000269|PubMed 17010156}. # InterPro IPR001633 EAL_dom # InterPro IPR024744 CSS-motif_dom # Organism YCGG_ECOLI Escherichia coli (strain K12) # PATRIC 32117571 VBIEscCol129921_1208 # PIR E64862 E64862 # PROSITE PS50883 EAL # Pfam PF00563 EAL # Pfam PF12792 CSS-motif # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCGG_ECOLI Uncharacterized protein YcgG # RefSeq NP_415686 NC_000913.3 # RefSeq WP_001246499 NZ_LN832404.1 # SIMILARITY Contains 1 EAL domain. {ECO:0000255|PROSITE- ProRule PRU00074}. # SMART SM00052 EAL # SUBCELLULAR LOCATION YCGG_ECOLI Cytoplasm {ECO 0000305}. Note=Found associated with the RNA degradosome. {ECO 0000269|PubMed 16139413}. # SUPFAM SSF141868 SSF141868 # eggNOG ENOG4105BZU Bacteria # eggNOG ENOG410XNMH LUCA BLAST swissprot:YCGG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCGG_ECOLI BioCyc ECOL316407:JW5174-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5174-MONOMER BioCyc EcoCyc:G6608-MONOMER http://biocyc.org/getid?id=EcoCyc:G6608-MONOMER DIP DIP-11554N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11554N DOI 10.1016/j.biochi.2005.07.012 http://dx.doi.org/10.1016/j.biochi.2005.07.012 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.2006.05440.x http://dx.doi.org/10.1111/j.1365-2958.2006.05440.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3647 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3647 EcoGene EG13888 http://www.ecogene.org/geneInfo.php?eg_id=EG13888 EnsemblBacteria AAC74252 http://www.ensemblgenomes.org/id/AAC74252 EnsemblBacteria AAC74252 http://www.ensemblgenomes.org/id/AAC74252 EnsemblBacteria BAA36000 http://www.ensemblgenomes.org/id/BAA36000 EnsemblBacteria BAA36000 http://www.ensemblgenomes.org/id/BAA36000 EnsemblBacteria BAA36000 http://www.ensemblgenomes.org/id/BAA36000 EnsemblBacteria b1168 http://www.ensemblgenomes.org/id/b1168 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 Gene3D 3.20.20.450 http://www.cathdb.info/version/latest/superfamily/3.20.20.450 GeneID 945738 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945738 HOGENOM HOG000273106 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000273106&db=HOGENOM6 InParanoid P75995 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75995 IntAct P75995 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75995* InterPro IPR001633 http://www.ebi.ac.uk/interpro/entry/IPR001633 InterPro IPR024744 http://www.ebi.ac.uk/interpro/entry/IPR024744 KEGG_Gene ecj:JW5174 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5174 KEGG_Gene eco:b1168 http://www.genome.jp/dbget-bin/www_bget?eco:b1168 OMA GTVWCTS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GTVWCTS PROSITE PS50883 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50883 PSORT swissprot:YCGG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCGG_ECOLI PSORT-B swissprot:YCGG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCGG_ECOLI PSORT2 swissprot:YCGG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCGG_ECOLI Pfam PF00563 http://pfam.xfam.org/family/PF00563 Pfam PF12792 http://pfam.xfam.org/family/PF12792 Phobius swissprot:YCGG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCGG_ECOLI PhylomeDB P75995 http://phylomedb.org/?seqid=P75995 ProteinModelPortal P75995 http://www.proteinmodelportal.org/query/uniprot/P75995 PubMed 16139413 http://www.ncbi.nlm.nih.gov/pubmed/16139413 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17010156 http://www.ncbi.nlm.nih.gov/pubmed/17010156 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415686 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415686 RefSeq WP_001246499 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001246499 SMART SM00052 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00052 SMR P75995 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75995 STRING 511145.b1168 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1168&targetmode=cogs SUPFAM SSF141868 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF141868 UniProtKB YCGG_ECOLI http://www.uniprot.org/uniprot/YCGG_ECOLI UniProtKB-AC P75995 http://www.uniprot.org/uniprot/P75995 charge swissprot:YCGG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCGG_ECOLI eggNOG ENOG4105BZU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZU eggNOG ENOG410XNMH http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNMH epestfind swissprot:YCGG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCGG_ECOLI garnier swissprot:YCGG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCGG_ECOLI helixturnhelix swissprot:YCGG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCGG_ECOLI hmoment swissprot:YCGG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCGG_ECOLI iep swissprot:YCGG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCGG_ECOLI inforesidue swissprot:YCGG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCGG_ECOLI octanol swissprot:YCGG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCGG_ECOLI pepcoil swissprot:YCGG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCGG_ECOLI pepdigest swissprot:YCGG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCGG_ECOLI pepinfo swissprot:YCGG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCGG_ECOLI pepnet swissprot:YCGG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCGG_ECOLI pepstats swissprot:YCGG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCGG_ECOLI pepwheel swissprot:YCGG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCGG_ECOLI pepwindow swissprot:YCGG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCGG_ECOLI sigcleave swissprot:YCGG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCGG_ECOLI ## Database ID URL or Descriptions # BioGrid 4262128 21 # EcoGene EG14003 ynjA # GO_function GO:0051920 peroxiredoxin activity; IEA:InterPro. # GOslim_function GO:0016491 oxidoreductase activity # Gene3D 1.20.1290.10 -; 1. # IntAct P76222 3 # InterPro IPR003779 CMD-like # InterPro IPR029032 AhpD-like # Organism YNJA_ECOLI Escherichia coli (strain K12) # PATRIC 32118817 VBIEscCol129921_1826 # PIR A64935 A64935 # Pfam PF02627 CMD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNJA_ECOLI Uncharacterized protein YnjA # RefSeq NP_416267 NC_000913.3 # RefSeq WP_000524097 NZ_LN832404.1 # SIMILARITY To M.tuberculosis Rv2313c. {ECO 0000305}. # SUPFAM SSF69118 SSF69118 # eggNOG COG2128 LUCA # eggNOG ENOG4107ZN8 Bacteria BLAST swissprot:YNJA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNJA_ECOLI BioCyc ECOL316407:JW1742-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1742-MONOMER BioCyc EcoCyc:G6948-MONOMER http://biocyc.org/getid?id=EcoCyc:G6948-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3759 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3759 EcoGene EG14003 http://www.ecogene.org/geneInfo.php?eg_id=EG14003 EnsemblBacteria AAC74823 http://www.ensemblgenomes.org/id/AAC74823 EnsemblBacteria AAC74823 http://www.ensemblgenomes.org/id/AAC74823 EnsemblBacteria BAE76520 http://www.ensemblgenomes.org/id/BAE76520 EnsemblBacteria BAE76520 http://www.ensemblgenomes.org/id/BAE76520 EnsemblBacteria BAE76520 http://www.ensemblgenomes.org/id/BAE76520 EnsemblBacteria b1753 http://www.ensemblgenomes.org/id/b1753 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0051920 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051920 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 Gene3D 1.20.1290.10 http://www.cathdb.info/version/latest/superfamily/1.20.1290.10 GeneID 946270 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946270 HOGENOM HOG000275296 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275296&db=HOGENOM6 InParanoid P76222 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76222 IntAct P76222 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76222* InterPro IPR003779 http://www.ebi.ac.uk/interpro/entry/IPR003779 InterPro IPR029032 http://www.ebi.ac.uk/interpro/entry/IPR029032 KEGG_Gene ecj:JW1742 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1742 KEGG_Gene eco:b1753 http://www.genome.jp/dbget-bin/www_bget?eco:b1753 OMA CEFCIDI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CEFCIDI PSORT swissprot:YNJA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNJA_ECOLI PSORT-B swissprot:YNJA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNJA_ECOLI PSORT2 swissprot:YNJA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNJA_ECOLI Pfam PF02627 http://pfam.xfam.org/family/PF02627 Phobius swissprot:YNJA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNJA_ECOLI PhylomeDB P76222 http://phylomedb.org/?seqid=P76222 ProteinModelPortal P76222 http://www.proteinmodelportal.org/query/uniprot/P76222 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416267 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416267 RefSeq WP_000524097 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000524097 SMR P76222 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76222 STRING 511145.b1753 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1753&targetmode=cogs SUPFAM SSF69118 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF69118 UniProtKB YNJA_ECOLI http://www.uniprot.org/uniprot/YNJA_ECOLI UniProtKB-AC P76222 http://www.uniprot.org/uniprot/P76222 charge swissprot:YNJA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNJA_ECOLI eggNOG COG2128 http://eggnogapi.embl.de/nog_data/html/tree/COG2128 eggNOG ENOG4107ZN8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107ZN8 epestfind swissprot:YNJA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNJA_ECOLI garnier swissprot:YNJA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNJA_ECOLI helixturnhelix swissprot:YNJA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNJA_ECOLI hmoment swissprot:YNJA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNJA_ECOLI iep swissprot:YNJA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNJA_ECOLI inforesidue swissprot:YNJA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNJA_ECOLI octanol swissprot:YNJA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNJA_ECOLI pepcoil swissprot:YNJA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNJA_ECOLI pepdigest swissprot:YNJA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNJA_ECOLI pepinfo swissprot:YNJA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNJA_ECOLI pepnet swissprot:YNJA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNJA_ECOLI pepstats swissprot:YNJA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNJA_ECOLI pepwheel swissprot:YNJA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNJA_ECOLI pepwindow swissprot:YNJA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNJA_ECOLI sigcleave swissprot:YNJA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNJA_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES HEM1_ECOLI Kinetic parameters KM=24 uM for L-glutamyl-tRNA(Glu) {ECO 0000269|PubMed 12370189}; KM=39 uM for NADPH {ECO 0000269|PubMed 12370189}; # BRENDA 1.2.1.70 2026 # CATALYTIC ACTIVITY L-glutamate 1-semialdehyde + NADP(+) + tRNA(Glu) = L-glutamyl-tRNA(Glu) + NADPH. {ECO:0000269|PubMed 12370189}. # DOMAIN HEM1_ECOLI Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization (By similarity). {ECO 0000250}. # ENZYME REGULATION Activated by Mg(2+) ions. Inhibited by metal- chelating agents such as EDTA, EGTA, 1,10-phenanthroline, 2,2'- dipyridyl, and by PtCl4 and KPdCl4 as well as Ni(2+) and Co(2+). Also inhibited by iodoacetamide, N-tosyl-L-phenylalanine chloromethyl ketone, and 5,5'-dithiobis(2-nitrobenzoic acid), as well as glutamycin. {ECO:0000269|PubMed 12370189}. # EcoGene EG10427 hemA # FUNCTION HEM1_ECOLI Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA). In the absence of NADPH, exhibits substrate esterase activity, leading to the release of glutamate from tRNA. {ECO 0000269|PubMed 12370189, ECO 0000269|PubMed 1569081}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0008883 glutamyl-tRNA reductase activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0050661 NADP binding; IBA:GO_Central. # GO_process GO:0019353 protoporphyrinogen IX biosynthetic process from glutamate; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.720 -; 1. # HAMAP MF_00087 Glu_tRNA_reductase # InterPro IPR000343 4pyrrol_synth_GluRdtase # InterPro IPR006151 Shikm_DH/Glu-tRNA_Rdtase # InterPro IPR015895 4pyrrol_synth_GluRdtase_N # InterPro IPR015896 4pyrrol_synth_GluRdtase_dimer # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR018214 GluRdtase_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00860 Porphyrin and chlorophyll metabolism # MISCELLANEOUS HEM1_ECOLI During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA. # Organism HEM1_ECOLI Escherichia coli (strain K12) # PATHWAY Porphyrin-containing compound metabolism; protoporphyrin- IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu) step 1/2. # PATRIC 32117672 VBIEscCol129921_1258 # PIR A45918 BVECHA # PIRSF PIRSF000445 4pyrrol_synth_GluRdtase # PROSITE PS00747 GLUTR # Pfam PF00745 GlutR_dimer # Pfam PF01488 Shikimate_DH # Pfam PF05201 GlutR_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HEM1_ECOLI Glutamyl-tRNA reductase # RefSeq NP_415728 NC_000913.3 # RefSeq WP_001299679 NZ_LN832404.1 # SIMILARITY Belongs to the glutamyl-tRNA reductase family. {ECO 0000305}. # SUBUNIT HEM1_ECOLI Homodimer. Interacts with glutamate-1-semialdehyde 2,1- aminomutase (GSA-AM), which forms a metabolic channeling between both enzymes to protect the reactive aldehyde species GSA. {ECO 0000269|PubMed 12370189, ECO 0000269|PubMed 15757895}. # SUPFAM SSF51735 SSF51735 # SUPFAM SSF69075 SSF69075 # SUPFAM SSF69742 SSF69742 # TIGRFAMs TIGR01035 hemA # UniPathway UPA00251 UER00316 # eggNOG COG0373 LUCA # eggNOG ENOG4105C7E Bacteria BLAST swissprot:HEM1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HEM1_ECOLI BioCyc ECOL316407:JW1201-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1201-MONOMER BioCyc EcoCyc:GLUTRNAREDUCT-MONOMER http://biocyc.org/getid?id=EcoCyc:GLUTRNAREDUCT-MONOMER BioCyc MetaCyc:GLUTRNAREDUCT-MONOMER http://biocyc.org/getid?id=MetaCyc:GLUTRNAREDUCT-MONOMER COG COG0373 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0373 DIP DIP-9877N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9877N DOI 10.1007/BF00334375 http://dx.doi.org/10.1007/BF00334375 DOI 10.1016/0378-1119(89)90046-2 http://dx.doi.org/10.1016/0378-1119(89)90046-2 DOI 10.1016/0378-1119(92)90170-T http://dx.doi.org/10.1016/0378-1119(92)90170-T DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M206924200 http://dx.doi.org/10.1074/jbc.M206924200 DOI 10.1074/jbc.M500440200 http://dx.doi.org/10.1074/jbc.M500440200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1742-4658.2007.05989.x http://dx.doi.org/10.1111/j.1742-4658.2007.05989.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.2.1.70 http://www.genome.jp/dbget-bin/www_bget?EC:1.2.1.70 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D10264 http://www.ebi.ac.uk/ena/data/view/D10264 EMBL M25323 http://www.ebi.ac.uk/ena/data/view/M25323 EMBL M30785 http://www.ebi.ac.uk/ena/data/view/M30785 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18555 http://www.ebi.ac.uk/ena/data/view/U18555 EMBL X17434 http://www.ebi.ac.uk/ena/data/view/X17434 ENZYME 1.2.1.70 http://enzyme.expasy.org/EC/1.2.1.70 EchoBASE EB0422 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0422 EcoGene EG10427 http://www.ecogene.org/geneInfo.php?eg_id=EG10427 EnsemblBacteria AAC74294 http://www.ensemblgenomes.org/id/AAC74294 EnsemblBacteria AAC74294 http://www.ensemblgenomes.org/id/AAC74294 EnsemblBacteria BAA36068 http://www.ensemblgenomes.org/id/BAA36068 EnsemblBacteria BAA36068 http://www.ensemblgenomes.org/id/BAA36068 EnsemblBacteria BAA36068 http://www.ensemblgenomes.org/id/BAA36068 EnsemblBacteria b1210 http://www.ensemblgenomes.org/id/b1210 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008883 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008883 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0050661 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050661 GO_process GO:0019353 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019353 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 945777 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945777 HAMAP MF_00087 http://hamap.expasy.org/unirule/MF_00087 HOGENOM HOG000109650 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000109650&db=HOGENOM6 InParanoid P0A6X1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6X1 IntAct P0A6X1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6X1* IntEnz 1.2.1.70 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.2.1.70 InterPro IPR000343 http://www.ebi.ac.uk/interpro/entry/IPR000343 InterPro IPR006151 http://www.ebi.ac.uk/interpro/entry/IPR006151 InterPro IPR015895 http://www.ebi.ac.uk/interpro/entry/IPR015895 InterPro IPR015896 http://www.ebi.ac.uk/interpro/entry/IPR015896 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR018214 http://www.ebi.ac.uk/interpro/entry/IPR018214 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1201 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1201 KEGG_Gene eco:b1210 http://www.genome.jp/dbget-bin/www_bget?eco:b1210 KEGG_Orthology KO:K02492 http://www.genome.jp/dbget-bin/www_bget?KO:K02492 KEGG_Pathway ko00860 http://www.genome.jp/kegg-bin/show_pathway?ko00860 KEGG_Reaction rn:R04109 http://www.genome.jp/dbget-bin/www_bget?rn:R04109 OMA NHCPNIK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NHCPNIK PROSITE PS00747 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00747 PSORT swissprot:HEM1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HEM1_ECOLI PSORT-B swissprot:HEM1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HEM1_ECOLI PSORT2 swissprot:HEM1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HEM1_ECOLI Pfam PF00745 http://pfam.xfam.org/family/PF00745 Pfam PF01488 http://pfam.xfam.org/family/PF01488 Pfam PF05201 http://pfam.xfam.org/family/PF05201 Phobius swissprot:HEM1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HEM1_ECOLI PhylomeDB P0A6X1 http://phylomedb.org/?seqid=P0A6X1 ProteinModelPortal P0A6X1 http://www.proteinmodelportal.org/query/uniprot/P0A6X1 PubMed 12370189 http://www.ncbi.nlm.nih.gov/pubmed/12370189 PubMed 1427085 http://www.ncbi.nlm.nih.gov/pubmed/1427085 PubMed 1569081 http://www.ncbi.nlm.nih.gov/pubmed/1569081 PubMed 15757895 http://www.ncbi.nlm.nih.gov/pubmed/15757895 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17697121 http://www.ncbi.nlm.nih.gov/pubmed/17697121 PubMed 2548996 http://www.ncbi.nlm.nih.gov/pubmed/2548996 PubMed 2664455 http://www.ncbi.nlm.nih.gov/pubmed/2664455 PubMed 2684779 http://www.ncbi.nlm.nih.gov/pubmed/2684779 PubMed 7543480 http://www.ncbi.nlm.nih.gov/pubmed/7543480 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415728 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415728 RefSeq WP_001299679 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001299679 SMR P0A6X1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6X1 STRING 511145.b1210 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1210&targetmode=cogs STRING COG0373 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0373&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 SUPFAM SSF69075 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF69075 SUPFAM SSF69742 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF69742 TIGRFAMs TIGR01035 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01035 UniProtKB HEM1_ECOLI http://www.uniprot.org/uniprot/HEM1_ECOLI UniProtKB-AC P0A6X1 http://www.uniprot.org/uniprot/P0A6X1 charge swissprot:HEM1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HEM1_ECOLI eggNOG COG0373 http://eggnogapi.embl.de/nog_data/html/tree/COG0373 eggNOG ENOG4105C7E http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C7E epestfind swissprot:HEM1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HEM1_ECOLI garnier swissprot:HEM1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HEM1_ECOLI helixturnhelix swissprot:HEM1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HEM1_ECOLI hmoment swissprot:HEM1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HEM1_ECOLI iep swissprot:HEM1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HEM1_ECOLI inforesidue swissprot:HEM1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HEM1_ECOLI octanol swissprot:HEM1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HEM1_ECOLI pepcoil swissprot:HEM1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HEM1_ECOLI pepdigest swissprot:HEM1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HEM1_ECOLI pepinfo swissprot:HEM1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HEM1_ECOLI pepnet swissprot:HEM1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HEM1_ECOLI pepstats swissprot:HEM1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HEM1_ECOLI pepwheel swissprot:HEM1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HEM1_ECOLI pepwindow swissprot:HEM1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HEM1_ECOLI sigcleave swissprot:HEM1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HEM1_ECOLI ## Database ID URL or Descriptions # BRENDA 3.1.2 2026 # BioGrid 4261906 3 # ESTHER ecoli-ybff 6_AlphaBeta_hydrolase # EcoGene EG11776 ybfF # FUNCTION YBFF_ECOLI Displays esterase activity toward palmitoyl-CoA, malonyl-CoA and pNP-butyrate. {ECO 0000269|PubMed 15808744}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0016790 thiolester hydrolase activity; IDA:EcoCyc. # GO_function GO:0052689 carboxylic ester hydrolase activity; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # Gene3D 3.40.50.1820 -; 1. # IntAct P75736 4 # InterPro IPR000073 AB_hydrolase_1 # InterPro IPR029058 AB_hydrolase # KEGG_Brite ko01000 Enzymes # Organism YBFF_ECOLI Escherichia coli (strain K12) # PATRIC 32116565 VBIEscCol129921_0715 # PDB 3BF7 X-ray; 1.10 A; A/B=1-254 # PDB 3BF8 X-ray; 1.68 A; A/B=1-254 # PIR E64803 E64803 # Pfam PF12697 Abhydrolase_6 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBFF_ECOLI Esterase YbfF # RefSeq NP_415212 NC_000913.3 # RefSeq WP_000773288 NZ_LN832404.1 # SIMILARITY Belongs to the DmpD/TodF/XylF esterase family. {ECO 0000305}. # SUPFAM SSF53474 SSF53474 # eggNOG COG0596 LUCA # eggNOG ENOG4105EV9 Bacteria BLAST swissprot:YBFF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBFF_ECOLI BioCyc ECOL316407:JW0673-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0673-MONOMER BioCyc EcoCyc:EG11776-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11776-MONOMER DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1016/j.fmrre.2004.12.006 http://dx.doi.org/10.1016/j.fmrre.2004.12.006 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.-.- http://enzyme.expasy.org/EC/3.1.-.- EchoBASE EB1725 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1725 EcoGene EG11776 http://www.ecogene.org/geneInfo.php?eg_id=EG11776 EnsemblBacteria AAC73780 http://www.ensemblgenomes.org/id/AAC73780 EnsemblBacteria AAC73780 http://www.ensemblgenomes.org/id/AAC73780 EnsemblBacteria BAA35335 http://www.ensemblgenomes.org/id/BAA35335 EnsemblBacteria BAA35335 http://www.ensemblgenomes.org/id/BAA35335 EnsemblBacteria BAA35335 http://www.ensemblgenomes.org/id/BAA35335 EnsemblBacteria b0686 http://www.ensemblgenomes.org/id/b0686 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0016790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016790 GO_function GO:0052689 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052689 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 Gene3D 3.40.50.1820 http://www.cathdb.info/version/latest/superfamily/3.40.50.1820 GeneID 945288 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945288 HOGENOM HOG000028067 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000028067&db=HOGENOM6 InParanoid P75736 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75736 IntAct P75736 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75736* IntEnz 3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1 InterPro IPR000073 http://www.ebi.ac.uk/interpro/entry/IPR000073 InterPro IPR029058 http://www.ebi.ac.uk/interpro/entry/IPR029058 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0673 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0673 KEGG_Gene eco:b0686 http://www.genome.jp/dbget-bin/www_bget?eco:b0686 KEGG_Orthology KO:K01175 http://www.genome.jp/dbget-bin/www_bget?KO:K01175 OMA FPYEPGE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FPYEPGE PDB 3BF7 http://www.ebi.ac.uk/pdbe-srv/view/entry/3BF7 PDB 3BF8 http://www.ebi.ac.uk/pdbe-srv/view/entry/3BF8 PDBsum 3BF7 http://www.ebi.ac.uk/pdbsum/3BF7 PDBsum 3BF8 http://www.ebi.ac.uk/pdbsum/3BF8 PSORT swissprot:YBFF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBFF_ECOLI PSORT-B swissprot:YBFF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBFF_ECOLI PSORT2 swissprot:YBFF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBFF_ECOLI Pfam PF12697 http://pfam.xfam.org/family/PF12697 Phobius swissprot:YBFF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBFF_ECOLI PhylomeDB P75736 http://phylomedb.org/?seqid=P75736 ProteinModelPortal P75736 http://www.proteinmodelportal.org/query/uniprot/P75736 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 15808744 http://www.ncbi.nlm.nih.gov/pubmed/15808744 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415212 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415212 RefSeq WP_000773288 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000773288 SMR P75736 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75736 STRING 511145.b0686 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0686&targetmode=cogs SUPFAM SSF53474 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53474 UniProtKB YBFF_ECOLI http://www.uniprot.org/uniprot/YBFF_ECOLI UniProtKB-AC P75736 http://www.uniprot.org/uniprot/P75736 charge swissprot:YBFF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBFF_ECOLI eggNOG COG0596 http://eggnogapi.embl.de/nog_data/html/tree/COG0596 eggNOG ENOG4105EV9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EV9 epestfind swissprot:YBFF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBFF_ECOLI garnier swissprot:YBFF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBFF_ECOLI helixturnhelix swissprot:YBFF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBFF_ECOLI hmoment swissprot:YBFF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBFF_ECOLI iep swissprot:YBFF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBFF_ECOLI inforesidue swissprot:YBFF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBFF_ECOLI octanol swissprot:YBFF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBFF_ECOLI pepcoil swissprot:YBFF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBFF_ECOLI pepdigest swissprot:YBFF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBFF_ECOLI pepinfo swissprot:YBFF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBFF_ECOLI pepnet swissprot:YBFF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBFF_ECOLI pepstats swissprot:YBFF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBFF_ECOLI pepwheel swissprot:YBFF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBFF_ECOLI pepwindow swissprot:YBFF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBFF_ECOLI sigcleave swissprot:YBFF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBFF_ECOLI ## Database ID URL or Descriptions # AltName PCNB_ECOLI Plasmid copy number protein # BRENDA 2.7.7.19 2026 # BioGrid 4263029 5 # CATALYTIC ACTIVITY PCNB_ECOLI ATP + RNA(n) = diphosphate + RNA(n+1). {ECO 0000255|HAMAP-Rule MF_00957, ECO 0000269|PubMed 1438224}. # CDD cd05398 NT_ClassII-CCAase # EcoGene EG10690 pcnB # FUNCTION PCNB_ECOLI Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control. Rho-independent transcription terminators may serve as polyadenylation signals. Seems to be involved in plasmid copy number control. {ECO 0000255|HAMAP-Rule MF_00957, ECO 0000269|PubMed 10594833, ECO 0000269|PubMed 1438224, ECO 0000269|PubMed 17040898}. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_function GO:0003723 RNA binding; IMP:EcoliWiki. # GO_function GO:0004652 polynucleotide adenylyltransferase activity; IDA:EcoliWiki. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006276 plasmid maintenance; IMP:EcoliWiki. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006378 mRNA polyadenylation; IMP:EcoliWiki. # GO_process GO:0006397 mRNA processing; IDA:EcoliWiki. # GO_process GO:0009451 RNA modification; IDA:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006397 mRNA processing # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # HAMAP MF_00957 PolyA_pol # INDUCTION Transcription regulation of pcnB is a complex process that involves several factors such as Sigma-70 (rpoD), Sigma-S (rpoS), ppGpp and DksA. {ECO:0000269|PubMed 20700605}. # IntAct P0ABF1 8 # InterPro IPR002646 PolA_pol_head_dom # InterPro IPR010206 PolA_pol_I # InterPro IPR025866 PolyA_pol_arg_C_dom # InterPro IPR032828 PolyA_RNA-bd # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko03018 RNA degradation # MISCELLANEOUS Uses the non-canonical initiation codon AUU, which limits pcnB expression. {ECO:0000305|PubMed 12068810}. # Organism PCNB_ECOLI Escherichia coli (strain K12) # PATRIC 32115393 VBIEscCol129921_0148 # PIR G64737 G64737 # Pfam PF01743 PolyA_pol # Pfam PF12626 PolyA_pol_arg_C # Pfam PF12627 PolyA_pol_RNAbd # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Poly(A) polymerase I {ECO:0000255|HAMAP-Rule MF_00957} # RefSeq NP_414685 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA24303.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAB24139.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. {ECO:0000255|HAMAP-Rule MF_00957}. # SUBCELLULAR LOCATION PCNB_ECOLI Cytoplasm {ECO 0000269|PubMed 15737627}. Cell inner membrane {ECO 0000269|PubMed 15737627}. # SUBUNIT Monomer. Interacts with CsdA, RhlE and SrmB. {ECO:0000269|PubMed 10361280}. # TIGRFAMs TIGR01942 pcnB # eggNOG COG0617 LUCA # eggNOG ENOG4105DJ0 Bacteria BLAST swissprot:PCNB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PCNB_ECOLI BioCyc ECOL316407:JW5808-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5808-MONOMER BioCyc EcoCyc:EG10690-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10690-MONOMER BioCyc MetaCyc:EG10690-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10690-MONOMER COG COG0617 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0617 DIP DIP-47859N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47859N DOI 10.1007/BF00260507 http://dx.doi.org/10.1007/BF00260507 DOI 10.1007/s00438-010-0567-y http://dx.doi.org/10.1007/s00438-010-0567-y DOI 10.1016/j.bbrc.2005.02.025 http://dx.doi.org/10.1016/j.bbrc.2005.02.025 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1999.01394.x http://dx.doi.org/10.1046/j.1365-2958.1999.01394.x DOI 10.1046/j.1365-2958.1999.01673.x http://dx.doi.org/10.1046/j.1365-2958.1999.01673.x DOI 10.1046/j.1365-2958.2002.02945.x http://dx.doi.org/10.1046/j.1365-2958.2002.02945.x DOI 10.1073/pnas.89.21.10380 http://dx.doi.org/10.1073/pnas.89.21.10380 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1093/nar/gkl684 http://dx.doi.org/10.1093/nar/gkl684 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.7.19 {ECO:0000255|HAMAP-Rule:MF_00957} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.19 {ECO:0000255|HAMAP-Rule:MF_00957} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M20574 http://www.ebi.ac.uk/ena/data/view/M20574 EMBL S48039 http://www.ebi.ac.uk/ena/data/view/S48039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.7.19 {ECO:0000255|HAMAP-Rule:MF_00957} http://enzyme.expasy.org/EC/2.7.7.19 {ECO:0000255|HAMAP-Rule:MF_00957} EchoBASE EB0684 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0684 EcoGene EG10690 http://www.ecogene.org/geneInfo.php?eg_id=EG10690 EnsemblBacteria AAC73254 http://www.ensemblgenomes.org/id/AAC73254 EnsemblBacteria AAC73254 http://www.ensemblgenomes.org/id/AAC73254 EnsemblBacteria BAB96720 http://www.ensemblgenomes.org/id/BAB96720 EnsemblBacteria BAB96720 http://www.ensemblgenomes.org/id/BAB96720 EnsemblBacteria BAB96720 http://www.ensemblgenomes.org/id/BAB96720 EnsemblBacteria b0143 http://www.ensemblgenomes.org/id/b0143 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0004652 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004652 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006276 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006378 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006378 GO_process GO:0006397 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006397 GO_process GO:0009451 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009451 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006397 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006397 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 947318 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947318 HAMAP MF_00957 http://hamap.expasy.org/unirule/MF_00957 HOGENOM HOG000256527 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000256527&db=HOGENOM6 InParanoid P0ABF1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABF1 IntAct P0ABF1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABF1* IntEnz 2.7.7.19 {ECO:0000255|HAMAP-Rule:MF_00957} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.19 {ECO:0000255|HAMAP-Rule:MF_00957} InterPro IPR002646 http://www.ebi.ac.uk/interpro/entry/IPR002646 InterPro IPR010206 http://www.ebi.ac.uk/interpro/entry/IPR010206 InterPro IPR025866 http://www.ebi.ac.uk/interpro/entry/IPR025866 InterPro IPR032828 http://www.ebi.ac.uk/interpro/entry/IPR032828 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5808 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5808 KEGG_Gene eco:b0143 http://www.genome.jp/dbget-bin/www_bget?eco:b0143 KEGG_Orthology KO:K00970 http://www.genome.jp/dbget-bin/www_bget?KO:K00970 KEGG_Pathway ko03018 http://www.genome.jp/kegg-bin/show_pathway?ko03018 OMA FMAKLDM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FMAKLDM PSORT swissprot:PCNB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PCNB_ECOLI PSORT-B swissprot:PCNB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PCNB_ECOLI PSORT2 swissprot:PCNB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PCNB_ECOLI Pfam PF01743 http://pfam.xfam.org/family/PF01743 Pfam PF12626 http://pfam.xfam.org/family/PF12626 Pfam PF12627 http://pfam.xfam.org/family/PF12627 Phobius swissprot:PCNB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PCNB_ECOLI PhylomeDB P0ABF1 http://phylomedb.org/?seqid=P0ABF1 ProteinModelPortal P0ABF1 http://www.proteinmodelportal.org/query/uniprot/P0ABF1 PubMed 10361280 http://www.ncbi.nlm.nih.gov/pubmed/10361280 PubMed 10594833 http://www.ncbi.nlm.nih.gov/pubmed/10594833 PubMed 12068810 http://www.ncbi.nlm.nih.gov/pubmed/12068810 PubMed 1438224 http://www.ncbi.nlm.nih.gov/pubmed/1438224 PubMed 15737627 http://www.ncbi.nlm.nih.gov/pubmed/15737627 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1691435 http://www.ncbi.nlm.nih.gov/pubmed/1691435 PubMed 17040898 http://www.ncbi.nlm.nih.gov/pubmed/17040898 PubMed 20700605 http://www.ncbi.nlm.nih.gov/pubmed/20700605 PubMed 2537812 http://www.ncbi.nlm.nih.gov/pubmed/2537812 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414685 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414685 SMR P0ABF1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABF1 STRING 511145.b0143 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0143&targetmode=cogs STRING COG0617 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0617&targetmode=cogs TIGRFAMs TIGR01942 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01942 UniProtKB PCNB_ECOLI http://www.uniprot.org/uniprot/PCNB_ECOLI UniProtKB-AC P0ABF1 http://www.uniprot.org/uniprot/P0ABF1 charge swissprot:PCNB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PCNB_ECOLI eggNOG COG0617 http://eggnogapi.embl.de/nog_data/html/tree/COG0617 eggNOG ENOG4105DJ0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DJ0 epestfind swissprot:PCNB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PCNB_ECOLI garnier swissprot:PCNB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PCNB_ECOLI helixturnhelix swissprot:PCNB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PCNB_ECOLI hmoment swissprot:PCNB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PCNB_ECOLI iep swissprot:PCNB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PCNB_ECOLI inforesidue swissprot:PCNB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PCNB_ECOLI octanol swissprot:PCNB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PCNB_ECOLI pepcoil swissprot:PCNB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PCNB_ECOLI pepdigest swissprot:PCNB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PCNB_ECOLI pepinfo swissprot:PCNB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PCNB_ECOLI pepnet swissprot:PCNB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PCNB_ECOLI pepstats swissprot:PCNB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PCNB_ECOLI pepwheel swissprot:PCNB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PCNB_ECOLI pepwindow swissprot:PCNB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PCNB_ECOLI sigcleave swissprot:PCNB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PCNB_ECOLI ## Database ID URL or Descriptions # BioGrid 4259872 208 # EcoGene EG13620 ybbY # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005215 transporter activity; IEA:InterPro. # GO_process GO:0055085 transmembrane transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0055085 transmembrane transport # INDUCTION YBBY_ECOLI By glyoxylate. # InterPro IPR006043 Xant/urac/vitC # Organism YBBY_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11119 PTHR11119 # PATRIC 32116183 VBIEscCol129921_0533 # Pfam PF00860 Xan_ur_permease # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBBY_ECOLI Putative purine permease YbbY # RefSeq NP_415046 NC_000913.3 # RefSeq WP_001302767 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40265.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION YBBY_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.40.5:the nucleobase/ascorbate transporter (nat) or nucleobase cation symporter-2 (ncs2) family # eggNOG COG2233 LUCA # eggNOG ENOG4105DTE Bacteria BLAST swissprot:YBBY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBBY_ECOLI BioCyc ECOL316407:JW0501-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0501-MONOMER BioCyc EcoCyc:G6282-MONOMER http://biocyc.org/getid?id=EcoCyc:G6282-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL U89279 http://www.ebi.ac.uk/ena/data/view/U89279 EchoBASE EB3385 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3385 EcoGene EG13620 http://www.ecogene.org/geneInfo.php?eg_id=EG13620 EnsemblBacteria AAC73615 http://www.ensemblgenomes.org/id/AAC73615 EnsemblBacteria AAC73615 http://www.ensemblgenomes.org/id/AAC73615 EnsemblBacteria BAE76291 http://www.ensemblgenomes.org/id/BAE76291 EnsemblBacteria BAE76291 http://www.ensemblgenomes.org/id/BAE76291 EnsemblBacteria BAE76291 http://www.ensemblgenomes.org/id/BAE76291 EnsemblBacteria b0513 http://www.ensemblgenomes.org/id/b0513 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 945131 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945131 HOGENOM HOG000117723 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117723&db=HOGENOM6 InParanoid P77328 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77328 InterPro IPR006043 http://www.ebi.ac.uk/interpro/entry/IPR006043 KEGG_Gene ecj:JW0501 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0501 KEGG_Gene eco:b0513 http://www.genome.jp/dbget-bin/www_bget?eco:b0513 OMA CNTVVIP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CNTVVIP PANTHER PTHR11119 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11119 PSORT swissprot:YBBY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBBY_ECOLI PSORT-B swissprot:YBBY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBBY_ECOLI PSORT2 swissprot:YBBY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBBY_ECOLI Pfam PF00860 http://pfam.xfam.org/family/PF00860 Phobius swissprot:YBBY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBBY_ECOLI PhylomeDB P77328 http://phylomedb.org/?seqid=P77328 ProteinModelPortal P77328 http://www.proteinmodelportal.org/query/uniprot/P77328 PubMed 10601204 http://www.ncbi.nlm.nih.gov/pubmed/10601204 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415046 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415046 RefSeq WP_001302767 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001302767 STRING 511145.b0513 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0513&targetmode=cogs TCDB 2.A.40.5 http://www.tcdb.org/search/result.php?tc=2.A.40.5 UniProtKB YBBY_ECOLI http://www.uniprot.org/uniprot/YBBY_ECOLI UniProtKB-AC P77328 http://www.uniprot.org/uniprot/P77328 charge swissprot:YBBY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBBY_ECOLI eggNOG COG2233 http://eggnogapi.embl.de/nog_data/html/tree/COG2233 eggNOG ENOG4105DTE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DTE epestfind swissprot:YBBY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBBY_ECOLI garnier swissprot:YBBY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBBY_ECOLI helixturnhelix swissprot:YBBY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBBY_ECOLI hmoment swissprot:YBBY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBBY_ECOLI iep swissprot:YBBY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBBY_ECOLI inforesidue swissprot:YBBY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBBY_ECOLI octanol swissprot:YBBY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBBY_ECOLI pepcoil swissprot:YBBY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBBY_ECOLI pepdigest swissprot:YBBY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBBY_ECOLI pepinfo swissprot:YBBY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBBY_ECOLI pepnet swissprot:YBBY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBBY_ECOLI pepstats swissprot:YBBY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBBY_ECOLI pepwheel swissprot:YBBY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBBY_ECOLI pepwindow swissprot:YBBY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBBY_ECOLI sigcleave swissprot:YBBY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBBY_ECOLI ## Database ID URL or Descriptions # BioGrid 4262063 16 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG13555 yagP # IntAct P75684 6 # InterPro IPR005119 LysR_subst-bd # Organism YAGP_ECOLI Escherichia coli (strain K12) # PATRIC 48659768 VBIEscCol107702_0279 # PIR B64754 B64754 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAGP_ECOLI Uncharacterized protein YagP # RefSeq WP_001111342 NZ_LN832404.1 # SIMILARITY To E.coli YafC and YgiP. {ECO 0000305}. BLAST swissprot:YAGP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAGP_ECOLI BioCyc ECOL316407:JW0276-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0276-MONOMER BioCyc EcoCyc:G6153-MONOMER http://biocyc.org/getid?id=EcoCyc:G6153-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3325 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3325 EcoGene EG13555 http://www.ecogene.org/geneInfo.php?eg_id=EG13555 EnsemblBacteria BAE76066 http://www.ensemblgenomes.org/id/BAE76066 EnsemblBacteria BAE76066 http://www.ensemblgenomes.org/id/BAE76066 EnsemblBacteria BAE76066 http://www.ensemblgenomes.org/id/BAE76066 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv HOGENOM HOG000050917 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000050917&db=HOGENOM6 InParanoid P75684 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75684 IntAct P75684 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75684* InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 KEGG_Gene ecj:JW0276 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0276 OMA YIFEQDI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YIFEQDI PSORT swissprot:YAGP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAGP_ECOLI PSORT-B swissprot:YAGP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAGP_ECOLI PSORT2 swissprot:YAGP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAGP_ECOLI Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:YAGP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAGP_ECOLI PhylomeDB P75684 http://phylomedb.org/?seqid=P75684 ProteinModelPortal P75684 http://www.proteinmodelportal.org/query/uniprot/P75684 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001111342 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001111342 SMR P75684 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75684 STRING 316407.85674426 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85674426&targetmode=cogs UniProtKB YAGP_ECOLI http://www.uniprot.org/uniprot/YAGP_ECOLI UniProtKB-AC P75684 http://www.uniprot.org/uniprot/P75684 charge swissprot:YAGP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAGP_ECOLI epestfind swissprot:YAGP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAGP_ECOLI garnier swissprot:YAGP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAGP_ECOLI helixturnhelix swissprot:YAGP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAGP_ECOLI hmoment swissprot:YAGP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAGP_ECOLI iep swissprot:YAGP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAGP_ECOLI inforesidue swissprot:YAGP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAGP_ECOLI octanol swissprot:YAGP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAGP_ECOLI pepcoil swissprot:YAGP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAGP_ECOLI pepdigest swissprot:YAGP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAGP_ECOLI pepinfo swissprot:YAGP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAGP_ECOLI pepnet swissprot:YAGP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAGP_ECOLI pepstats swissprot:YAGP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAGP_ECOLI pepwheel swissprot:YAGP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAGP_ECOLI pepwindow swissprot:YAGP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAGP_ECOLI sigcleave swissprot:YAGP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAGP_ECOLI ## Database ID URL or Descriptions # BioGrid 4260571 9 # EcoGene EG11432 yfeD # Gene3D 1.10.10.10 -; 1. # IntAct P27238 5 # InterPro IPR009061 DNA-bd_dom_put # InterPro IPR010749 DUF1323 # InterPro IPR011991 WHTH_DNA-bd_dom # Organism YFED_ECOLI Escherichia coli (strain K12) # PATRIC 32120175 VBIEscCol129921_2494 # PIR S11409 S11409 # Pfam PF07037 DUF1323 # ProDom PD060594 DUF1323 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFED_ECOLI Uncharacterized protein YfeD # RefSeq NP_416898 NC_000913.3 # RefSeq WP_000826503 NZ_LN832404.1 # SUPFAM SSF46955 SSF46955 # eggNOG ENOG4105GXM Bacteria # eggNOG ENOG4111SP1 LUCA BLAST swissprot:YFED_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFED_ECOLI BioCyc ECOL316407:JW2394-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2394-MONOMER BioCyc EcoCyc:EG11432-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11432-MONOMER DIP DIP-12013N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12013N DOI 10.1016/0022-2836(90)90339-N http://dx.doi.org/10.1016/0022-2836(90)90339-N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M13687 http://www.ebi.ac.uk/ena/data/view/M13687 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X63976 http://www.ebi.ac.uk/ena/data/view/X63976 EchoBASE EB1402 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1402 EcoGene EG11432 http://www.ecogene.org/geneInfo.php?eg_id=EG11432 EnsemblBacteria AAC75456 http://www.ensemblgenomes.org/id/AAC75456 EnsemblBacteria AAC75456 http://www.ensemblgenomes.org/id/AAC75456 EnsemblBacteria BAA16271 http://www.ensemblgenomes.org/id/BAA16271 EnsemblBacteria BAA16271 http://www.ensemblgenomes.org/id/BAA16271 EnsemblBacteria BAA16271 http://www.ensemblgenomes.org/id/BAA16271 EnsemblBacteria b2399 http://www.ensemblgenomes.org/id/b2399 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 946865 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946865 HOGENOM HOG000122974 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122974&db=HOGENOM6 IntAct P27238 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P27238* InterPro IPR009061 http://www.ebi.ac.uk/interpro/entry/IPR009061 InterPro IPR010749 http://www.ebi.ac.uk/interpro/entry/IPR010749 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW2394 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2394 KEGG_Gene eco:b2399 http://www.genome.jp/dbget-bin/www_bget?eco:b2399 PSORT swissprot:YFED_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFED_ECOLI PSORT-B swissprot:YFED_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFED_ECOLI PSORT2 swissprot:YFED_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFED_ECOLI Pfam PF07037 http://pfam.xfam.org/family/PF07037 Phobius swissprot:YFED_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFED_ECOLI ProteinModelPortal P27238 http://www.proteinmodelportal.org/query/uniprot/P27238 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2201776 http://www.ncbi.nlm.nih.gov/pubmed/2201776 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416898 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416898 RefSeq WP_000826503 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000826503 SMR P27238 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P27238 STRING 511145.b2399 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2399&targetmode=cogs SUPFAM SSF46955 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46955 UniProtKB YFED_ECOLI http://www.uniprot.org/uniprot/YFED_ECOLI UniProtKB-AC P27238 http://www.uniprot.org/uniprot/P27238 charge swissprot:YFED_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFED_ECOLI eggNOG ENOG4105GXM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105GXM eggNOG ENOG4111SP1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111SP1 epestfind swissprot:YFED_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFED_ECOLI garnier swissprot:YFED_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFED_ECOLI helixturnhelix swissprot:YFED_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFED_ECOLI hmoment swissprot:YFED_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFED_ECOLI iep swissprot:YFED_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFED_ECOLI inforesidue swissprot:YFED_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFED_ECOLI octanol swissprot:YFED_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFED_ECOLI pepcoil swissprot:YFED_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFED_ECOLI pepdigest swissprot:YFED_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFED_ECOLI pepinfo swissprot:YFED_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFED_ECOLI pepnet swissprot:YFED_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFED_ECOLI pepstats swissprot:YFED_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFED_ECOLI pepwheel swissprot:YFED_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFED_ECOLI pepwindow swissprot:YFED_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFED_ECOLI sigcleave swissprot:YFED_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFED_ECOLI ## Database ID URL or Descriptions # BioGrid 4261930 8 # EcoGene EG12060 napC # FUNCTION NAPC_ECOLI Mediates electron flow from quinones to the NapAB complex. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IBA:GO_Central. # GO_function GO:0009055 electron carrier activity; IBA:GO_Central. # GO_function GO:0020037 heme binding; IEA:InterPro. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0009061 anaerobic respiration; IMP:EcoCyc. # GO_process GO:0019333 denitrification pathway; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0071941 nitrogen cycle metabolic process # IntAct P0ABL5 43 # InterPro IPR005126 NapC/NirT_cyt_c_N # InterPro IPR011031 Multihaem_cyt # InterPro IPR011885 NO3Rdtase_cyt_c_NapC/NirT # InterPro IPR024717 NapC/NirT/NrfH # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko00910 Nitrogen metabolism # Organism NAPC_ECOLI Escherichia coli (strain K12) # PATRIC 32119763 VBIEscCol129921_2291 # PIR H64989 H64989 # PIRSF PIRSF000013 4_hem_cytochrm_NapC # PROSITE PS51008 MULTIHEME_CYTC # PTM NAPC_ECOLI Binds 4 heme groups per subunit. {ECO 0000305}. # Pfam PF03264 Cytochrom_NNT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NAPC_ECOLI Cytochrome c-type protein NapC # RefSeq NP_416706 NC_000913.3 # RefSeq WP_000528376 NZ_LN832404.1 # SUBCELLULAR LOCATION NAPC_ECOLI Cell inner membrane; Single-pass membrane protein. # SUPFAM SSF48695 SSF48695 # TIGRFAMs TIGR02161 napC_nirT # eggNOG COG3005 LUCA # eggNOG ENOG4105CUW Bacteria BLAST swissprot:NAPC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NAPC_ECOLI BioCyc ECOL316407:JW2190-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2190-MONOMER BioCyc EcoCyc:NAPC-MONOMER http://biocyc.org/getid?id=EcoCyc:NAPC-MONOMER BioCyc MetaCyc:NAPC-MONOMER http://biocyc.org/getid?id=MetaCyc:NAPC-MONOMER COG COG3005 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3005 DIP DIP-10306N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10306N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1574-6968.1994.tb06872.x http://dx.doi.org/10.1111/j.1574-6968.1994.tb06872.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00008 http://www.ebi.ac.uk/ena/data/view/U00008 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1990 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1990 EcoGene EG12060 http://www.ecogene.org/geneInfo.php?eg_id=EG12060 EnsemblBacteria AAC75262 http://www.ensemblgenomes.org/id/AAC75262 EnsemblBacteria AAC75262 http://www.ensemblgenomes.org/id/AAC75262 EnsemblBacteria BAE76665 http://www.ensemblgenomes.org/id/BAE76665 EnsemblBacteria BAE76665 http://www.ensemblgenomes.org/id/BAE76665 EnsemblBacteria BAE76665 http://www.ensemblgenomes.org/id/BAE76665 EnsemblBacteria b2202 http://www.ensemblgenomes.org/id/b2202 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0020037 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0020037 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0009061 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009061 GO_process GO:0019333 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019333 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0071941 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071941 GeneID 946706 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946706 HOGENOM HOG000275532 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275532&db=HOGENOM6 InParanoid P0ABL5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABL5 IntAct P0ABL5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABL5* InterPro IPR005126 http://www.ebi.ac.uk/interpro/entry/IPR005126 InterPro IPR011031 http://www.ebi.ac.uk/interpro/entry/IPR011031 InterPro IPR011885 http://www.ebi.ac.uk/interpro/entry/IPR011885 InterPro IPR024717 http://www.ebi.ac.uk/interpro/entry/IPR024717 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW2190 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2190 KEGG_Gene eco:b2202 http://www.genome.jp/dbget-bin/www_bget?eco:b2202 KEGG_Orthology KO:K02569 http://www.genome.jp/dbget-bin/www_bget?KO:K02569 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Reaction rn:R00798 http://www.genome.jp/dbget-bin/www_bget?rn:R00798 OMA CTGCHEM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CTGCHEM PROSITE PS51008 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51008 PSORT swissprot:NAPC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NAPC_ECOLI PSORT-B swissprot:NAPC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NAPC_ECOLI PSORT2 swissprot:NAPC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NAPC_ECOLI Pfam PF03264 http://pfam.xfam.org/family/PF03264 Phobius swissprot:NAPC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NAPC_ECOLI PhylomeDB P0ABL5 http://phylomedb.org/?seqid=P0ABL5 ProteinModelPortal P0ABL5 http://www.proteinmodelportal.org/query/uniprot/P0ABL5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8039676 http://www.ncbi.nlm.nih.gov/pubmed/8039676 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416706 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416706 RefSeq WP_000528376 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000528376 STRING 511145.b2202 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2202&targetmode=cogs STRING COG3005 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3005&targetmode=cogs SUPFAM SSF48695 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48695 TIGRFAMs TIGR02161 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02161 UniProtKB NAPC_ECOLI http://www.uniprot.org/uniprot/NAPC_ECOLI UniProtKB-AC P0ABL5 http://www.uniprot.org/uniprot/P0ABL5 charge swissprot:NAPC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NAPC_ECOLI eggNOG COG3005 http://eggnogapi.embl.de/nog_data/html/tree/COG3005 eggNOG ENOG4105CUW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CUW epestfind swissprot:NAPC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NAPC_ECOLI garnier swissprot:NAPC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NAPC_ECOLI helixturnhelix swissprot:NAPC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NAPC_ECOLI hmoment swissprot:NAPC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NAPC_ECOLI iep swissprot:NAPC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NAPC_ECOLI inforesidue swissprot:NAPC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NAPC_ECOLI octanol swissprot:NAPC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NAPC_ECOLI pepcoil swissprot:NAPC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NAPC_ECOLI pepdigest swissprot:NAPC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NAPC_ECOLI pepinfo swissprot:NAPC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NAPC_ECOLI pepnet swissprot:NAPC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NAPC_ECOLI pepstats swissprot:NAPC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NAPC_ECOLI pepwheel swissprot:NAPC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NAPC_ECOLI pepwindow swissprot:NAPC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NAPC_ECOLI sigcleave swissprot:NAPC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NAPC_ECOLI ## Database ID URL or Descriptions # BioGrid 4259135 114 # EcoGene EG13991 ydjO # Organism YDJO_ECOLI Escherichia coli (strain K12) # PATRIC 32118767 VBIEscCol129921_1801 # PIR B64932 B64932 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDJO_ECOLI Uncharacterized protein YdjO # RefSeq NP_416244 NC_000913.3 # RefSeq WP_001310874 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAE76512.1; Type=Erroneous initiation; Evidence={ECO 0000305}; BLAST swissprot:YDJO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDJO_ECOLI BioCyc ECOL316407:JW1719-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1719-MONOMER BioCyc EcoCyc:G6935-MONOMER http://biocyc.org/getid?id=EcoCyc:G6935-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3747 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3747 EcoGene EG13991 http://www.ecogene.org/geneInfo.php?eg_id=EG13991 EnsemblBacteria AAC74800 http://www.ensemblgenomes.org/id/AAC74800 EnsemblBacteria AAC74800 http://www.ensemblgenomes.org/id/AAC74800 EnsemblBacteria BAE76512 http://www.ensemblgenomes.org/id/BAE76512 EnsemblBacteria BAE76512 http://www.ensemblgenomes.org/id/BAE76512 EnsemblBacteria BAE76512 http://www.ensemblgenomes.org/id/BAE76512 EnsemblBacteria b1730 http://www.ensemblgenomes.org/id/b1730 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946237 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946237 HOGENOM HOG000009731 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009731&db=HOGENOM6 IntAct P76210 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76210* KEGG_Gene ecj:JW1719 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1719 KEGG_Gene eco:b1730 http://www.genome.jp/dbget-bin/www_bget?eco:b1730 PSORT swissprot:YDJO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDJO_ECOLI PSORT-B swissprot:YDJO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDJO_ECOLI PSORT2 swissprot:YDJO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDJO_ECOLI Phobius swissprot:YDJO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDJO_ECOLI ProteinModelPortal P76210 http://www.proteinmodelportal.org/query/uniprot/P76210 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416244 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416244 RefSeq WP_001310874 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001310874 SMR P76210 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76210 STRING 511145.b1730 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1730&targetmode=cogs UniProtKB YDJO_ECOLI http://www.uniprot.org/uniprot/YDJO_ECOLI UniProtKB-AC P76210 http://www.uniprot.org/uniprot/P76210 charge swissprot:YDJO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDJO_ECOLI epestfind swissprot:YDJO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDJO_ECOLI garnier swissprot:YDJO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDJO_ECOLI helixturnhelix swissprot:YDJO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDJO_ECOLI hmoment swissprot:YDJO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDJO_ECOLI iep swissprot:YDJO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDJO_ECOLI inforesidue swissprot:YDJO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDJO_ECOLI octanol swissprot:YDJO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDJO_ECOLI pepcoil swissprot:YDJO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDJO_ECOLI pepdigest swissprot:YDJO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDJO_ECOLI pepinfo swissprot:YDJO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDJO_ECOLI pepnet swissprot:YDJO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDJO_ECOLI pepstats swissprot:YDJO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDJO_ECOLI pepwheel swissprot:YDJO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDJO_ECOLI pepwindow swissprot:YDJO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDJO_ECOLI sigcleave swissprot:YDJO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDJO_ECOLI ## Database ID URL or Descriptions # AltName YGHU_ECOLI GSH-dependent disulfide-bond oxidoreductase YghU # AltName YGHU_ECOLI GST N2-2 # AltName YGHU_ECOLI Organic hydroperoxidase # BIOPHYSICOCHEMICAL PROPERTIES YGHU_ECOLI Kinetic parameters KM=80 uM for glutathione (when assaying the GSH transferase activity with CDNB) {ECO 0000269|PubMed 21222452}; KM=1.1 mM for glutathione (when assaying the disulfide-bond reductase activity with 2-hydroxyethyl disulfide) {ECO 0000269|PubMed 21222452}; KM=16 uM for cumene hydroperoxide {ECO 0000269|PubMed 21222452}; KM=130 uM for linoleic acid 13(S)-hydroperoxide {ECO 0000269|PubMed 21222452}; KM=28 uM for 15(S)-HpETE {ECO 0000269|PubMed 21222452}; Note=kcat is 74 sec(-1) for the disulfide-bond reductase reaction toward 2-hydroxyethyl disulfide. kcat is 0.050, 0.19 and 0.096 sec(-1) for the hydroperoxidase reaction with cumene hydroperoxide, linoleic acid 13(S)-hydroperoxide, and 15(S)- HpETE as substrate, respectively. kcat is 0.109 sec(-1) for the GSH transferase reaction with CDNB as substrate.; # BioGrid 4261179 10 # EcoGene EG13005 yghU # FUNCTION YGHU_ECOLI Exhibits a robust glutathione (GSH)-dependent disulfide- bond reductase activity toward the model substrate, 2-hydroxyethyl disulfide; the actual physiological substrates are not known. Also displays a modest GSH-dependent peroxidase activity toward several organic hydroperoxides, such as cumene hydroperoxide and linoleic acid 13(S)-hydroperoxide, but does not reduce H(2)O(2) or tert- butyl hydroperoxide at appreciable rates. Exhibits little or no GSH transferase activity with most typical electrophilic substrates, and has no detectable transferase activity toward 1- chloro-2,4-dinitrobenzene (CDNB) with glutathionylspermidine (GspSH) as the nucleophilic substrate. {ECO 0000269|PubMed 21222452}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0004364 glutathione transferase activity; IBA:GO_Central. # GO_function GO:0004601 peroxidase activity; IEA:UniProtKB-KW. # GO_function GO:0015036 disulfide oxidoreductase activity; IDA:EcoCyc. # GO_process GO:0006749 glutathione metabolic process; IBA:GO_Central. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.20.1050.10 -; 1. # Gene3D 3.40.30.10 -; 1. # InterPro IPR004045 Glutathione_S-Trfase_N # InterPro IPR010987 Glutathione-S-Trfase_C-like # InterPro IPR012336 Thioredoxin-like_fold # MISCELLANEOUS YGHU_ECOLI Binds two molecules of GSH in each active site; there is one tight and one weak binding site for GSH. # Organism YGHU_ECOLI Escherichia coli (strain K12) # PATRIC 32121394 VBIEscCol129921_3084 # PDB 3C8E X-ray; 1.50 A; A/B=1-288 # PROSITE PS50404 GST_NTER # PROSITE PS50405 GST_CTER # Pfam PF02798 GST_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGHU_ECOLI Disulfide-bond oxidoreductase YghU # RefSeq NP_417463 NC_000913.3 # RefSeq WP_001295515 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA69156.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the GST superfamily. Nu-class GSH transferase family. {ECO 0000305}. # SIMILARITY Contains 1 GST C-terminal domain. {ECO 0000305}. # SIMILARITY Contains 1 GST N-terminal domain. {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 21222452}. # SUPFAM SSF47616 SSF47616 # SUPFAM SSF52833 SSF52833 # eggNOG COG0625 LUCA # eggNOG ENOG4105CYM Bacteria BLAST swissprot:YGHU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGHU_ECOLI BioCyc ECOL316407:JW5492-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5492-MONOMER BioCyc EcoCyc:G7553-MONOMER http://biocyc.org/getid?id=EcoCyc:G7553-MONOMER BioCyc MetaCyc:G7553-MONOMER http://biocyc.org/getid?id=MetaCyc:G7553-MONOMER COG COG0625 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0625 DIP DIP-12212N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12212N DOI 10.1021/bi101861a http://dx.doi.org/10.1021/bi101861a DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.11.1.- http://www.genome.jp/dbget-bin/www_bget?EC:1.11.1.- EC_number EC:1.8.4.- http://www.genome.jp/dbget-bin/www_bget?EC:1.8.4.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 ENZYME 1.11.1.- http://enzyme.expasy.org/EC/1.11.1.- ENZYME 1.8.4.- http://enzyme.expasy.org/EC/1.8.4.- EchoBASE EB2827 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2827 EcoGene EG13005 http://www.ecogene.org/geneInfo.php?eg_id=EG13005 EnsemblBacteria AAC76025 http://www.ensemblgenomes.org/id/AAC76025 EnsemblBacteria AAC76025 http://www.ensemblgenomes.org/id/AAC76025 EnsemblBacteria BAE77050 http://www.ensemblgenomes.org/id/BAE77050 EnsemblBacteria BAE77050 http://www.ensemblgenomes.org/id/BAE77050 EnsemblBacteria BAE77050 http://www.ensemblgenomes.org/id/BAE77050 EnsemblBacteria b2989 http://www.ensemblgenomes.org/id/b2989 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004364 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004364 GO_function GO:0004601 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004601 GO_function GO:0015036 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015036 GO_process GO:0006749 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006749 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016765 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.20.1050.10 http://www.cathdb.info/version/latest/superfamily/1.20.1050.10 Gene3D 3.40.30.10 http://www.cathdb.info/version/latest/superfamily/3.40.30.10 GeneID 947472 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947472 HOGENOM HOG000125752 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125752&db=HOGENOM6 InParanoid Q46845 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46845 IntEnz 1.11.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.11.1 IntEnz 1.8.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.8.4 InterPro IPR004045 http://www.ebi.ac.uk/interpro/entry/IPR004045 InterPro IPR010987 http://www.ebi.ac.uk/interpro/entry/IPR010987 InterPro IPR012336 http://www.ebi.ac.uk/interpro/entry/IPR012336 KEGG_Gene ecj:JW5492 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5492 KEGG_Gene eco:b2989 http://www.genome.jp/dbget-bin/www_bget?eco:b2989 KEGG_Orthology KO:K11209 http://www.genome.jp/dbget-bin/www_bget?KO:K11209 OMA YVPPKVW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YVPPKVW PDB 3C8E http://www.ebi.ac.uk/pdbe-srv/view/entry/3C8E PDBsum 3C8E http://www.ebi.ac.uk/pdbsum/3C8E PROSITE PS50404 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50404 PROSITE PS50405 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50405 PSORT swissprot:YGHU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGHU_ECOLI PSORT-B swissprot:YGHU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGHU_ECOLI PSORT2 swissprot:YGHU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGHU_ECOLI Pfam PF02798 http://pfam.xfam.org/family/PF02798 Phobius swissprot:YGHU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGHU_ECOLI PhylomeDB Q46845 http://phylomedb.org/?seqid=Q46845 ProteinModelPortal Q46845 http://www.proteinmodelportal.org/query/uniprot/Q46845 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21222452 http://www.ncbi.nlm.nih.gov/pubmed/21222452 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417463 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417463 RefSeq WP_001295515 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295515 SMR Q46845 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46845 STRING 511145.b2989 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2989&targetmode=cogs STRING COG0625 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0625&targetmode=cogs SUPFAM SSF47616 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47616 SUPFAM SSF52833 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52833 UniProtKB YGHU_ECOLI http://www.uniprot.org/uniprot/YGHU_ECOLI UniProtKB-AC Q46845 http://www.uniprot.org/uniprot/Q46845 charge swissprot:YGHU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGHU_ECOLI eggNOG COG0625 http://eggnogapi.embl.de/nog_data/html/tree/COG0625 eggNOG ENOG4105CYM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CYM epestfind swissprot:YGHU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGHU_ECOLI garnier swissprot:YGHU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGHU_ECOLI helixturnhelix swissprot:YGHU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGHU_ECOLI hmoment swissprot:YGHU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGHU_ECOLI iep swissprot:YGHU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGHU_ECOLI inforesidue swissprot:YGHU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGHU_ECOLI octanol swissprot:YGHU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGHU_ECOLI pepcoil swissprot:YGHU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGHU_ECOLI pepdigest swissprot:YGHU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGHU_ECOLI pepinfo swissprot:YGHU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGHU_ECOLI pepnet swissprot:YGHU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGHU_ECOLI pepstats swissprot:YGHU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGHU_ECOLI pepwheel swissprot:YGHU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGHU_ECOLI pepwindow swissprot:YGHU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGHU_ECOLI sigcleave swissprot:YGHU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGHU_ECOLI ## Database ID URL or Descriptions # BioGrid 4259342 9 # DISRUPTION PHENOTYPE No visible effect on bacterial persistence. {ECO:0000269|PubMed 26051177}. # EcoGene EG11499 yhbE # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006810 transport; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006810 transport # InterPro IPR000620 EamA_dom # Organism YHBE_ECOLI Escherichia coli (strain K12) # PATRIC 32121788 VBIEscCol129921_3278 # PIR B65109 B65109 # Pfam PF00892 EamA; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHBE_ECOLI Uncharacterized inner membrane transporter YhbE # RefSeq NP_417651 NC_000913.3 # RefSeq WP_000813037 NZ_LN832404.1 # SIMILARITY Belongs to the EamA transporter family. {ECO 0000305}. # SIMILARITY Contains 2 EamA domains. {ECO 0000305}. # SUBCELLULAR LOCATION YHBE_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG COG0697 LUCA # eggNOG ENOG4105QYV Bacteria BLAST swissprot:YHBE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHBE_ECOLI BioCyc ECOL316407:JW3151-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3151-MONOMER BioCyc EcoCyc:EG11499-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11499-MONOMER DOI 10.1016/j.molcel.2015.05.011 http://dx.doi.org/10.1016/j.molcel.2015.05.011 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D13267 http://www.ebi.ac.uk/ena/data/view/D13267 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB1462 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1462 EcoGene EG11499 http://www.ecogene.org/geneInfo.php?eg_id=EG11499 EnsemblBacteria AAC76216 http://www.ensemblgenomes.org/id/AAC76216 EnsemblBacteria AAC76216 http://www.ensemblgenomes.org/id/AAC76216 EnsemblBacteria BAE77228 http://www.ensemblgenomes.org/id/BAE77228 EnsemblBacteria BAE77228 http://www.ensemblgenomes.org/id/BAE77228 EnsemblBacteria BAE77228 http://www.ensemblgenomes.org/id/BAE77228 EnsemblBacteria b3184 http://www.ensemblgenomes.org/id/b3184 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 947699 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947699 HOGENOM HOG000000467 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000000467&db=HOGENOM6 InParanoid P0AA73 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AA73 InterPro IPR000620 http://www.ebi.ac.uk/interpro/entry/IPR000620 KEGG_Gene ecj:JW3151 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3151 KEGG_Gene eco:b3184 http://www.genome.jp/dbget-bin/www_bget?eco:b3184 OMA CFIYCCL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CFIYCCL PSORT swissprot:YHBE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHBE_ECOLI PSORT-B swissprot:YHBE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHBE_ECOLI PSORT2 swissprot:YHBE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHBE_ECOLI Pfam PF00892 http://pfam.xfam.org/family/PF00892 Phobius swissprot:YHBE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHBE_ECOLI PhylomeDB P0AA73 http://phylomedb.org/?seqid=P0AA73 ProteinModelPortal P0AA73 http://www.proteinmodelportal.org/query/uniprot/P0AA73 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 26051177 http://www.ncbi.nlm.nih.gov/pubmed/26051177 PubMed 8312607 http://www.ncbi.nlm.nih.gov/pubmed/8312607 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417651 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417651 RefSeq WP_000813037 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000813037 STRING 511145.b3184 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3184&targetmode=cogs UniProtKB YHBE_ECOLI http://www.uniprot.org/uniprot/YHBE_ECOLI UniProtKB-AC P0AA73 http://www.uniprot.org/uniprot/P0AA73 charge swissprot:YHBE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHBE_ECOLI eggNOG COG0697 http://eggnogapi.embl.de/nog_data/html/tree/COG0697 eggNOG ENOG4105QYV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105QYV epestfind swissprot:YHBE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHBE_ECOLI garnier swissprot:YHBE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHBE_ECOLI helixturnhelix swissprot:YHBE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHBE_ECOLI hmoment swissprot:YHBE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHBE_ECOLI iep swissprot:YHBE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHBE_ECOLI inforesidue swissprot:YHBE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHBE_ECOLI octanol swissprot:YHBE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHBE_ECOLI pepcoil swissprot:YHBE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHBE_ECOLI pepdigest swissprot:YHBE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHBE_ECOLI pepinfo swissprot:YHBE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHBE_ECOLI pepnet swissprot:YHBE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHBE_ECOLI pepstats swissprot:YHBE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHBE_ECOLI pepwheel swissprot:YHBE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHBE_ECOLI pepwindow swissprot:YHBE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHBE_ECOLI sigcleave swissprot:YHBE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHBE_ECOLI ## Database ID URL or Descriptions # AltName OMPA_ECOLI Outer membrane protein II* # BioGrid 4260032 1011 # CDD cd07185 OmpA_C-like # EcoGene EG10669 ompA # FUNCTION OMPA_ECOLI Required for the action of colicins K and L and for the stabilization of mating aggregates in conjugation. Serves as a receptor for a number of T-even like phages. Also acts as a porin with low permeability that allows slow penetration of small solutes. # GO_component GO:0009279 cell outer membrane; IDA:EcoliWiki. # GO_component GO:0016020 membrane; IDA:EcoliWiki. # GO_component GO:0016021 integral component of membrane; IDA:EcoliWiki. # GO_component GO:0019867 outer membrane; IDA:EcoliWiki. # GO_component GO:0046930 pore complex; IDA:EcoCyc. # GO_function GO:0005198 structural molecule activity; IEA:InterPro. # GO_function GO:0015288 porin activity; IDA:EcoCyc. # GO_process GO:0000746 conjugation; IMP:EcoliWiki. # GO_process GO:0006810 transport; IDA:EcoliWiki. # GO_process GO:0006811 ion transport; IDA:EcoliWiki. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0009597 detection of virus; IMP:EcoliWiki. # GO_process GO:0034220 ion transmembrane transport; IDA:EcoCyc. # GO_process GO:0046718 viral entry into host cell; IMP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043234 protein complex # GOslim_function GO:0005198 structural molecule activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0044403 symbiosis, encompassing mutualism through parasitism # GOslim_process GO:0055085 transmembrane transport # Gene3D 2.40.160.20 -; 1. # Gene3D 3.30.1330.60 -; 1. # INTERACTION OMPA_ECOLI P0C0V0 degP; NbExp=6; IntAct=EBI-371347, EBI-547165; P69411 rcsF; NbExp=3; IntAct=EBI-371347, EBI-1114706; P0A850 tig; NbExp=3; IntAct=EBI-371347, EBI-544862; # IntAct P0A910 13 # InterPro IPR000498 OmpA-like_TM_dom # InterPro IPR002368 OmpA # InterPro IPR006664 OMP_bac # InterPro IPR006665 OmpA-like # InterPro IPR006690 OMPA-like_CS # InterPro IPR011250 OMP/PagP_b-brl # KEGG_Brite ko02000 Transporters # MASS SPECTROMETRY Mass=35177; Method=Electrospray; Range=22-346; Evidence={ECO:0000269|PubMed 10757971}; # Organism OMPA_ECOLI Escherichia coli (strain K12) # PATRIC 32117133 VBIEscCol129921_0991 # PDB 1BXW X-ray; 2.50 A; A=21-192 # PDB 1G90 NMR; -; A=22-197 # PDB 1QJP X-ray; 1.65 A; A=22-192 # PDB 2GE4 NMR; -; A=22-197 # PDB 2JMM NMR; -; A=23-197 # PDB 3NB3 EM; -; A/B/C=1-346 # PIR A93707 MMECA # PRINTS PR01021 OMPADOMAIN # PRINTS PR01022 OUTRMMBRANEA # PROSITE PS01068 OMPA_1 # PROSITE PS51123 OMPA_2 # Pfam PF00691 OmpA # Pfam PF01389 OmpA_membrane # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName OMPA_ECOLI Outer membrane protein A # RefSeq NP_415477 NC_000913.3 # RefSeq WP_000750416 NZ_LN832404.1 # SIMILARITY Belongs to the OmpA family. {ECO 0000305}. # SIMILARITY Contains 1 OmpA-like domain. {ECO:0000255|PROSITE- ProRule PRU00473}. # SUBCELLULAR LOCATION OMPA_ECOLI Cell outer membrane {ECO 0000269|PubMed 16079137, ECO 0000269|PubMed 21778229, ECO 0000269|PubMed 7813480}; Multi-pass membrane protein {ECO 0000269|PubMed 16079137, ECO 0000269|PubMed 21778229, ECO 0000269|PubMed 7813480}. # SUBUNIT OMPA_ECOLI Homodimer. # SUPFAM SSF103088 SSF103088 # SUPFAM SSF56925 SSF56925 # TCDB 1.B.6.1 the ompa-ompf porin (oop) family # eggNOG COG2885 LUCA # eggNOG ENOG4105UYK Bacteria BLAST swissprot:OMPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:OMPA_ECOLI BioCyc ECOL316407:JW0940-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0940-MONOMER BioCyc EcoCyc:EG10669-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10669-MONOMER COG COG2885 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2885 DIP DIP-31879N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31879N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1002/elps.1150190539 http://dx.doi.org/10.1002/elps.1150190539 DOI 10.1006/jmbi.2000.3671 http://dx.doi.org/10.1006/jmbi.2000.3671 DOI 10.1016/0022-2836(80)90193-X http://dx.doi.org/10.1016/0022-2836(80)90193-X DOI 10.1021/bi000150m http://dx.doi.org/10.1021/bi000150m DOI 10.1038/2983 http://dx.doi.org/10.1038/2983 DOI 10.1038/86214 http://dx.doi.org/10.1038/86214 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.77.8.4592 http://dx.doi.org/10.1073/pnas.77.8.4592 DOI 10.1074/jbc.M111.245696 http://dx.doi.org/10.1074/jbc.M111.245696 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/8.13.3011 http://dx.doi.org/10.1093/nar/8.13.3011 DOI 10.1111/j.1432-1033.1994.00891.x http://dx.doi.org/10.1111/j.1432-1033.1994.00891.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00307 http://www.ebi.ac.uk/ena/data/view/V00307 EchoBASE EB0663 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0663 EcoGene EG10669 http://www.ecogene.org/geneInfo.php?eg_id=EG10669 EnsemblBacteria AAC74043 http://www.ensemblgenomes.org/id/AAC74043 EnsemblBacteria AAC74043 http://www.ensemblgenomes.org/id/AAC74043 EnsemblBacteria BAA35715 http://www.ensemblgenomes.org/id/BAA35715 EnsemblBacteria BAA35715 http://www.ensemblgenomes.org/id/BAA35715 EnsemblBacteria BAA35715 http://www.ensemblgenomes.org/id/BAA35715 EnsemblBacteria b0957 http://www.ensemblgenomes.org/id/b0957 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0019867 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019867 GO_component GO:0046930 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046930 GO_function GO:0005198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005198 GO_function GO:0015288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015288 GO_process GO:0000746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000746 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GO_process GO:0006811 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0009597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009597 GO_process GO:0034220 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220 GO_process GO:0046718 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046718 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0005198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005198 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0044403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 2.40.160.20 http://www.cathdb.info/version/latest/superfamily/2.40.160.20 Gene3D 3.30.1330.60 http://www.cathdb.info/version/latest/superfamily/3.30.1330.60 GeneID 945571 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945571 HOGENOM HOG000274199 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000274199&db=HOGENOM6 InParanoid P0A910 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A910 IntAct P0A910 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A910* InterPro IPR000498 http://www.ebi.ac.uk/interpro/entry/IPR000498 InterPro IPR002368 http://www.ebi.ac.uk/interpro/entry/IPR002368 InterPro IPR006664 http://www.ebi.ac.uk/interpro/entry/IPR006664 InterPro IPR006665 http://www.ebi.ac.uk/interpro/entry/IPR006665 InterPro IPR006690 http://www.ebi.ac.uk/interpro/entry/IPR006690 InterPro IPR011250 http://www.ebi.ac.uk/interpro/entry/IPR011250 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0940 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0940 KEGG_Gene eco:b0957 http://www.genome.jp/dbget-bin/www_bget?eco:b0957 KEGG_Orthology KO:K03286 http://www.genome.jp/dbget-bin/www_bget?KO:K03286 MINT MINT-1308131 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1308131 OMA EYALTKN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EYALTKN PDB 1BXW http://www.ebi.ac.uk/pdbe-srv/view/entry/1BXW PDB 1G90 http://www.ebi.ac.uk/pdbe-srv/view/entry/1G90 PDB 1QJP http://www.ebi.ac.uk/pdbe-srv/view/entry/1QJP PDB 2GE4 http://www.ebi.ac.uk/pdbe-srv/view/entry/2GE4 PDB 2JMM http://www.ebi.ac.uk/pdbe-srv/view/entry/2JMM PDB 3NB3 http://www.ebi.ac.uk/pdbe-srv/view/entry/3NB3 PDBsum 1BXW http://www.ebi.ac.uk/pdbsum/1BXW PDBsum 1G90 http://www.ebi.ac.uk/pdbsum/1G90 PDBsum 1QJP http://www.ebi.ac.uk/pdbsum/1QJP PDBsum 2GE4 http://www.ebi.ac.uk/pdbsum/2GE4 PDBsum 2JMM http://www.ebi.ac.uk/pdbsum/2JMM PDBsum 3NB3 http://www.ebi.ac.uk/pdbsum/3NB3 PRINTS PR01021 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01021 PRINTS PR01022 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01022 PROSITE PS01068 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01068 PROSITE PS51123 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51123 PSORT swissprot:OMPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:OMPA_ECOLI PSORT-B swissprot:OMPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:OMPA_ECOLI PSORT2 swissprot:OMPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:OMPA_ECOLI Pfam PF00691 http://pfam.xfam.org/family/PF00691 Pfam PF01389 http://pfam.xfam.org/family/PF01389 Phobius swissprot:OMPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:OMPA_ECOLI ProteinModelPortal P0A910 http://www.proteinmodelportal.org/query/uniprot/P0A910 PubMed 10368142 http://www.ncbi.nlm.nih.gov/pubmed/10368142 PubMed 10757971 http://www.ncbi.nlm.nih.gov/pubmed/10757971 PubMed 10764596 http://www.ncbi.nlm.nih.gov/pubmed/10764596 PubMed 11276254 http://www.ncbi.nlm.nih.gov/pubmed/11276254 PubMed 1370823 http://www.ncbi.nlm.nih.gov/pubmed/1370823 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21778229 http://www.ncbi.nlm.nih.gov/pubmed/21778229 PubMed 3902787 http://www.ncbi.nlm.nih.gov/pubmed/3902787 PubMed 6086577 http://www.ncbi.nlm.nih.gov/pubmed/6086577 PubMed 6253901 http://www.ncbi.nlm.nih.gov/pubmed/6253901 PubMed 6260961 http://www.ncbi.nlm.nih.gov/pubmed/6260961 PubMed 7001461 http://www.ncbi.nlm.nih.gov/pubmed/7001461 PubMed 7813480 http://www.ncbi.nlm.nih.gov/pubmed/7813480 PubMed 8106193 http://www.ncbi.nlm.nih.gov/pubmed/8106193 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9629924 http://www.ncbi.nlm.nih.gov/pubmed/9629924 PubMed 9808047 http://www.ncbi.nlm.nih.gov/pubmed/9808047 RefSeq NP_415477 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415477 RefSeq WP_000750416 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000750416 SMR P0A910 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A910 STRING 511145.b0957 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0957&targetmode=cogs STRING COG2885 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2885&targetmode=cogs SUPFAM SSF103088 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103088 SUPFAM SSF56925 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56925 SWISS-2DPAGE P0A910 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A910 TCDB 1.B.6.1 http://www.tcdb.org/search/result.php?tc=1.B.6.1 UniProtKB OMPA_ECOLI http://www.uniprot.org/uniprot/OMPA_ECOLI UniProtKB-AC P0A910 http://www.uniprot.org/uniprot/P0A910 charge swissprot:OMPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:OMPA_ECOLI eggNOG COG2885 http://eggnogapi.embl.de/nog_data/html/tree/COG2885 eggNOG ENOG4105UYK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105UYK epestfind swissprot:OMPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:OMPA_ECOLI garnier swissprot:OMPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:OMPA_ECOLI helixturnhelix swissprot:OMPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:OMPA_ECOLI hmoment swissprot:OMPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:OMPA_ECOLI iep swissprot:OMPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:OMPA_ECOLI inforesidue swissprot:OMPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:OMPA_ECOLI octanol swissprot:OMPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:OMPA_ECOLI pepcoil swissprot:OMPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:OMPA_ECOLI pepdigest swissprot:OMPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:OMPA_ECOLI pepinfo swissprot:OMPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:OMPA_ECOLI pepnet swissprot:OMPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:OMPA_ECOLI pepstats swissprot:OMPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:OMPA_ECOLI pepwheel swissprot:OMPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:OMPA_ECOLI pepwindow swissprot:OMPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:OMPA_ECOLI sigcleave swissprot:OMPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:OMPA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259950 14 # CDD cd00886 MogA_MoaB # EcoGene EG11596 moaB # FUNCTION MOAB_ECOLI May be involved in the biosynthesis of molybdopterin. Can bind GTP and has low GTPase activity. Can bind MPT, but has no MPT adenylyl transferase activity. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0005525 GTP binding; IEA:UniProtKB-KW. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0061598 molybdopterin adenylyltransferase activity; IBA:GO_Central. # GO_function GO:0061599 molybdopterin molybdotransferase activity; IBA:GO_Central. # GO_process GO:0006777 Mo-molybdopterin cofactor biosynthetic process; IBA:GO_Central. # GO_process GO:0018315 molybdenum incorporation into molybdenum-molybdopterin complex; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.980.10 -; 1. # INDUCTION MOAB_ECOLI By anaerobiosis, repressed by the molybdenum cofactor. # IntAct P0AEZ9 4 # InterPro IPR001453 MoaB/Mog_dom # InterPro IPR008284 MoCF_biosynth_CS # InterPro IPR012245 MoaB # InterPro IPR013484 MoaB_proteobac # Organism MOAB_ECOLI Escherichia coli (strain K12) # PATHWAY MOAB_ECOLI Cofactor biosynthesis; molybdopterin biosynthesis. # PATRIC 32116765 VBIEscCol129921_0808 # PDB 1MKZ X-ray; 1.60 A; A/B=1-170 # PDB 1R2K X-ray; 2.10 A; A/B=2-170 # PIR S34999 S31880 # PIRSF PIRSF006443 MoaB # PROSITE PS01078 MOCF_BIOSYNTHESIS_1 # Pfam PF00994 MoCF_biosynth # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MOAB_ECOLI Molybdenum cofactor biosynthesis protein B # RefSeq NP_415303 NC_000913.3 # RefSeq WP_000084639 NZ_LN832404.1 # SIMILARITY Belongs to the MoaB/Mog family. {ECO 0000305}. # SMART SM00852 MoCF_biosynth # SUBUNIT Homohexamer. Dimer of trimers. {ECO:0000269|PubMed 15269205}. # SUPFAM SSF53218 SSF53218 # TIGRFAMs TIGR00177 molyb_syn # TIGRFAMs TIGR02667 moaB_proteo # eggNOG COG0521 LUCA # eggNOG ENOG4108RIR Bacteria BLAST swissprot:MOAB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MOAB_ECOLI BioCyc ECOL316407:JW0765-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0765-MONOMER BioCyc EcoCyc:MONOMER0-1501 http://biocyc.org/getid?id=EcoCyc:MONOMER0-1501 COG COG0521 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0521 DOI 10.1021/bi7020487 http://dx.doi.org/10.1021/bi7020487 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M407694200 http://dx.doi.org/10.1074/jbc.M407694200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1107/S0907444904007164 http://dx.doi.org/10.1107/S0907444904007164 DOI 10.1111/j.1365-2958.1993.tb01652.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb01652.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X70420 http://www.ebi.ac.uk/ena/data/view/X70420 EchoBASE EB1553 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1553 EcoGene EG11596 http://www.ecogene.org/geneInfo.php?eg_id=EG11596 EnsemblBacteria AAC73869 http://www.ensemblgenomes.org/id/AAC73869 EnsemblBacteria AAC73869 http://www.ensemblgenomes.org/id/AAC73869 EnsemblBacteria BAA35440 http://www.ensemblgenomes.org/id/BAA35440 EnsemblBacteria BAA35440 http://www.ensemblgenomes.org/id/BAA35440 EnsemblBacteria BAA35440 http://www.ensemblgenomes.org/id/BAA35440 EnsemblBacteria b0782 http://www.ensemblgenomes.org/id/b0782 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0061598 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061598 GO_function GO:0061599 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061599 GO_process GO:0006777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006777 GO_process GO:0018315 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018315 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.980.10 http://www.cathdb.info/version/latest/superfamily/3.40.980.10 GeneID 945396 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945396 HOGENOM HOG000281102 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000281102&db=HOGENOM6 InParanoid P0AEZ9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEZ9 IntAct P0AEZ9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEZ9* InterPro IPR001453 http://www.ebi.ac.uk/interpro/entry/IPR001453 InterPro IPR008284 http://www.ebi.ac.uk/interpro/entry/IPR008284 InterPro IPR012245 http://www.ebi.ac.uk/interpro/entry/IPR012245 InterPro IPR013484 http://www.ebi.ac.uk/interpro/entry/IPR013484 KEGG_Gene ecj:JW0765 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0765 KEGG_Gene eco:b0782 http://www.genome.jp/dbget-bin/www_bget?eco:b0782 KEGG_Orthology KO:K03638 http://www.genome.jp/dbget-bin/www_bget?KO:K03638 MINT MINT-1301713 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1301713 OMA IGTATIQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IGTATIQ PDB 1MKZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1MKZ PDB 1R2K http://www.ebi.ac.uk/pdbe-srv/view/entry/1R2K PDBsum 1MKZ http://www.ebi.ac.uk/pdbsum/1MKZ PDBsum 1R2K http://www.ebi.ac.uk/pdbsum/1R2K PROSITE PS01078 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01078 PSORT swissprot:MOAB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MOAB_ECOLI PSORT-B swissprot:MOAB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MOAB_ECOLI PSORT2 swissprot:MOAB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MOAB_ECOLI Pfam PF00994 http://pfam.xfam.org/family/PF00994 Phobius swissprot:MOAB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MOAB_ECOLI PhylomeDB P0AEZ9 http://phylomedb.org/?seqid=P0AEZ9 ProteinModelPortal P0AEZ9 http://www.proteinmodelportal.org/query/uniprot/P0AEZ9 PubMed 15159566 http://www.ncbi.nlm.nih.gov/pubmed/15159566 PubMed 15269205 http://www.ncbi.nlm.nih.gov/pubmed/15269205 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18154309 http://www.ncbi.nlm.nih.gov/pubmed/18154309 PubMed 8361352 http://www.ncbi.nlm.nih.gov/pubmed/8361352 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415303 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415303 RefSeq WP_000084639 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000084639 SMART SM00852 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00852 SMR P0AEZ9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEZ9 STRING 511145.b0782 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0782&targetmode=cogs STRING COG0521 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0521&targetmode=cogs SUPFAM SSF53218 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53218 SWISS-2DPAGE P0AEZ9 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AEZ9 TIGRFAMs TIGR00177 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00177 TIGRFAMs TIGR02667 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02667 UniProtKB MOAB_ECOLI http://www.uniprot.org/uniprot/MOAB_ECOLI UniProtKB-AC P0AEZ9 http://www.uniprot.org/uniprot/P0AEZ9 charge swissprot:MOAB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MOAB_ECOLI eggNOG COG0521 http://eggnogapi.embl.de/nog_data/html/tree/COG0521 eggNOG ENOG4108RIR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108RIR epestfind swissprot:MOAB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MOAB_ECOLI garnier swissprot:MOAB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MOAB_ECOLI helixturnhelix swissprot:MOAB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MOAB_ECOLI hmoment swissprot:MOAB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MOAB_ECOLI iep swissprot:MOAB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MOAB_ECOLI inforesidue swissprot:MOAB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MOAB_ECOLI octanol swissprot:MOAB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MOAB_ECOLI pepcoil swissprot:MOAB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MOAB_ECOLI pepdigest swissprot:MOAB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MOAB_ECOLI pepinfo swissprot:MOAB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MOAB_ECOLI pepnet swissprot:MOAB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MOAB_ECOLI pepstats swissprot:MOAB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MOAB_ECOLI pepwheel swissprot:MOAB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MOAB_ECOLI pepwindow swissprot:MOAB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MOAB_ECOLI sigcleave swissprot:MOAB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MOAB_ECOLI ## Database ID URL or Descriptions # BioGrid 4261804 11 # EcoGene EG13296 frmR # FUNCTION FRMR_ECOLI Repressor of the frmRAB operon. {ECO 0000269|PubMed 15466022}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0046872 metal ion binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # INDUCTION Induced by formaldehyde. Negatively autoregulated. {ECO:0000269|PubMed 15466022}. # IntAct P0AAP3 2 # InterPro IPR003735 Metal_Tscrpt_repr # Organism FRMR_ECOLI Escherichia coli (strain K12) # PATRIC 32115853 VBIEscCol129921_0368 # Pfam PF02583 Trns_repr_metal # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FRMR_ECOLI Transcriptional repressor FrmR # RefSeq NP_414891 NC_000913.3 # RefSeq WP_001141271 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18082.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=D85613; Type=Frameshift; Positions=20; Evidence={ECO 0000305}; # SIMILARITY Belongs to the FrmR/RcnR family. {ECO 0000305}. # SUBCELLULAR LOCATION FRMR_ECOLI Cytoplasm {ECO 0000305}. # eggNOG COG1937 LUCA # eggNOG ENOG4105VEG Bacteria BLAST swissprot:FRMR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FRMR_ECOLI BioCyc ECOL316407:JW0348-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0348-MONOMER BioCyc EcoCyc:G6209-MONOMER http://biocyc.org/getid?id=EcoCyc:G6209-MONOMER DIP DIP-48245N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48245N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.186.20.6714-6720.2004 http://dx.doi.org/10.1128/JB.186.20.6714-6720.2004 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D85613 http://www.ebi.ac.uk/ena/data/view/D85613 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB3081 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3081 EcoGene EG13296 http://www.ecogene.org/geneInfo.php?eg_id=EG13296 EnsemblBacteria AAC73460 http://www.ensemblgenomes.org/id/AAC73460 EnsemblBacteria AAC73460 http://www.ensemblgenomes.org/id/AAC73460 EnsemblBacteria BAE76139 http://www.ensemblgenomes.org/id/BAE76139 EnsemblBacteria BAE76139 http://www.ensemblgenomes.org/id/BAE76139 EnsemblBacteria BAE76139 http://www.ensemblgenomes.org/id/BAE76139 EnsemblBacteria b0357 http://www.ensemblgenomes.org/id/b0357 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 944986 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944986 HOGENOM HOG000023914 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000023914&db=HOGENOM6 InParanoid P0AAP3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAP3 IntAct P0AAP3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAP3* InterPro IPR003735 http://www.ebi.ac.uk/interpro/entry/IPR003735 KEGG_Gene ecj:JW0348 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0348 KEGG_Gene eco:b0357 http://www.genome.jp/dbget-bin/www_bget?eco:b0357 OMA HIRDHLM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HIRDHLM PSORT swissprot:FRMR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FRMR_ECOLI PSORT-B swissprot:FRMR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FRMR_ECOLI PSORT2 swissprot:FRMR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FRMR_ECOLI Pfam PF02583 http://pfam.xfam.org/family/PF02583 Phobius swissprot:FRMR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FRMR_ECOLI PhylomeDB P0AAP3 http://phylomedb.org/?seqid=P0AAP3 ProteinModelPortal P0AAP3 http://www.proteinmodelportal.org/query/uniprot/P0AAP3 PubMed 15466022 http://www.ncbi.nlm.nih.gov/pubmed/15466022 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8808933 http://www.ncbi.nlm.nih.gov/pubmed/8808933 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414891 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414891 RefSeq WP_001141271 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001141271 STRING 511145.b0357 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0357&targetmode=cogs UniProtKB FRMR_ECOLI http://www.uniprot.org/uniprot/FRMR_ECOLI UniProtKB-AC P0AAP3 http://www.uniprot.org/uniprot/P0AAP3 charge swissprot:FRMR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FRMR_ECOLI eggNOG COG1937 http://eggnogapi.embl.de/nog_data/html/tree/COG1937 eggNOG ENOG4105VEG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VEG epestfind swissprot:FRMR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FRMR_ECOLI garnier swissprot:FRMR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FRMR_ECOLI helixturnhelix swissprot:FRMR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FRMR_ECOLI hmoment swissprot:FRMR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FRMR_ECOLI iep swissprot:FRMR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FRMR_ECOLI inforesidue swissprot:FRMR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FRMR_ECOLI octanol swissprot:FRMR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FRMR_ECOLI pepcoil swissprot:FRMR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FRMR_ECOLI pepdigest swissprot:FRMR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FRMR_ECOLI pepinfo swissprot:FRMR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FRMR_ECOLI pepnet swissprot:FRMR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FRMR_ECOLI pepstats swissprot:FRMR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FRMR_ECOLI pepwheel swissprot:FRMR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FRMR_ECOLI pepwindow swissprot:FRMR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FRMR_ECOLI sigcleave swissprot:FRMR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FRMR_ECOLI ## Database ID URL or Descriptions # BioGrid 4260702 9 # EcoGene EG11129 rem # IntAct P07010 2 # InterPro IPR016418 UCP004509_Rem # Organism REM_ECOLI Escherichia coli (strain K12) # PATRIC 32118426 VBIEscCol129921_1633 # PIR D22830 QQECR9 # PIRSF PIRSF004509 UCP004509_Rem # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName REM_ECOLI Uncharacterized protein Rem # RefSeq NP_416079 NC_000913.3 # RefSeq WP_000980994 NZ_LN832404.1 BLAST swissprot:REM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:REM_ECOLI BioCyc ECOL316407:JW1553-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1553-MONOMER BioCyc EcoCyc:EG11129-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11129-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X02405 http://www.ebi.ac.uk/ena/data/view/X02405 EchoBASE EB1119 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1119 EcoGene EG11129 http://www.ecogene.org/geneInfo.php?eg_id=EG11129 EnsemblBacteria AAC74634 http://www.ensemblgenomes.org/id/AAC74634 EnsemblBacteria AAC74634 http://www.ensemblgenomes.org/id/AAC74634 EnsemblBacteria BAA15260 http://www.ensemblgenomes.org/id/BAA15260 EnsemblBacteria BAA15260 http://www.ensemblgenomes.org/id/BAA15260 EnsemblBacteria BAA15260 http://www.ensemblgenomes.org/id/BAA15260 EnsemblBacteria b1561 http://www.ensemblgenomes.org/id/b1561 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946109 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946109 HOGENOM HOG000009452 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009452&db=HOGENOM6 IntAct P07010 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P07010* InterPro IPR016418 http://www.ebi.ac.uk/interpro/entry/IPR016418 KEGG_Gene ecj:JW1553 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1553 KEGG_Gene eco:b1561 http://www.genome.jp/dbget-bin/www_bget?eco:b1561 OMA VSHYRIL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VSHYRIL PSORT swissprot:REM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:REM_ECOLI PSORT-B swissprot:REM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:REM_ECOLI PSORT2 swissprot:REM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:REM_ECOLI Phobius swissprot:REM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:REM_ECOLI ProteinModelPortal P07010 http://www.proteinmodelportal.org/query/uniprot/P07010 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2990907 http://www.ncbi.nlm.nih.gov/pubmed/2990907 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416079 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416079 RefSeq WP_000980994 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000980994 STRING 511145.b1561 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1561&targetmode=cogs UniProtKB REM_ECOLI http://www.uniprot.org/uniprot/REM_ECOLI UniProtKB-AC P07010 http://www.uniprot.org/uniprot/P07010 charge swissprot:REM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:REM_ECOLI epestfind swissprot:REM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:REM_ECOLI garnier swissprot:REM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:REM_ECOLI helixturnhelix swissprot:REM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:REM_ECOLI hmoment swissprot:REM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:REM_ECOLI iep swissprot:REM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:REM_ECOLI inforesidue swissprot:REM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:REM_ECOLI octanol swissprot:REM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:REM_ECOLI pepcoil swissprot:REM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:REM_ECOLI pepdigest swissprot:REM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:REM_ECOLI pepinfo swissprot:REM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:REM_ECOLI pepnet swissprot:REM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:REM_ECOLI pepstats swissprot:REM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:REM_ECOLI pepwheel swissprot:REM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:REM_ECOLI pepwindow swissprot:REM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:REM_ECOLI sigcleave swissprot:REM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:REM_ECOLI ## Database ID URL or Descriptions # BioGrid 4261750 9 # EcoGene EG13348 yjjZ # InterPro IPR009885 DUF1435 # Organism YJJZ_ECOLI Escherichia coli (strain K12) # PATRIC 32124344 VBIEscCol129921_4515 # Pfam PF07256 DUF1435 # ProDom PD058594 DUF1435 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJJZ_ECOLI Uncharacterized protein YjjZ # RefSeq YP_588478 NC_000913.3 # eggNOG ENOG4105YBH Bacteria # eggNOG ENOG41127TY LUCA BLAST swissprot:YJJZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJJZ_ECOLI BioCyc ECOL316407:JW5797-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5797-MONOMER BioCyc EcoCyc:MONOMER0-2696 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2696 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB3132 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3132 EcoGene EG13348 http://www.ecogene.org/geneInfo.php?eg_id=EG13348 EnsemblBacteria ABD18719 http://www.ensemblgenomes.org/id/ABD18719 EnsemblBacteria ABD18719 http://www.ensemblgenomes.org/id/ABD18719 EnsemblBacteria BAE78358 http://www.ensemblgenomes.org/id/BAE78358 EnsemblBacteria BAE78358 http://www.ensemblgenomes.org/id/BAE78358 EnsemblBacteria BAE78358 http://www.ensemblgenomes.org/id/BAE78358 EnsemblBacteria b4567 http://www.ensemblgenomes.org/id/b4567 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1450313 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1450313 HOGENOM HOG000127628 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000127628&db=HOGENOM6 InterPro IPR009885 http://www.ebi.ac.uk/interpro/entry/IPR009885 KEGG_Gene ecj:JW5797 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5797 KEGG_Gene eco:b4567 http://www.genome.jp/dbget-bin/www_bget?eco:b4567 OMA VFIINER http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VFIINER PSORT swissprot:YJJZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJJZ_ECOLI PSORT-B swissprot:YJJZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJJZ_ECOLI PSORT2 swissprot:YJJZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJJZ_ECOLI Pfam PF07256 http://pfam.xfam.org/family/PF07256 Phobius swissprot:YJJZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJJZ_ECOLI ProteinModelPortal P55914 http://www.proteinmodelportal.org/query/uniprot/P55914 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq YP_588478 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_588478 STRING 511145.b4567 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4567&targetmode=cogs UniProtKB YJJZ_ECOLI http://www.uniprot.org/uniprot/YJJZ_ECOLI UniProtKB-AC P55914 http://www.uniprot.org/uniprot/P55914 charge swissprot:YJJZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJJZ_ECOLI eggNOG ENOG4105YBH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105YBH eggNOG ENOG41127TY http://eggnogapi.embl.de/nog_data/html/tree/ENOG41127TY epestfind swissprot:YJJZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJJZ_ECOLI garnier swissprot:YJJZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJJZ_ECOLI helixturnhelix swissprot:YJJZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJJZ_ECOLI hmoment swissprot:YJJZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJJZ_ECOLI iep swissprot:YJJZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJJZ_ECOLI inforesidue swissprot:YJJZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJJZ_ECOLI octanol swissprot:YJJZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJJZ_ECOLI pepcoil swissprot:YJJZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJJZ_ECOLI pepdigest swissprot:YJJZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJJZ_ECOLI pepinfo swissprot:YJJZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJJZ_ECOLI pepnet swissprot:YJJZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJJZ_ECOLI pepstats swissprot:YJJZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJJZ_ECOLI pepwheel swissprot:YJJZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJJZ_ECOLI pepwindow swissprot:YJJZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJJZ_ECOLI sigcleave swissprot:YJJZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJJZ_ECOLI ## Database ID URL or Descriptions # AltName YCED_ECOLI G30K # BioGrid 4261028 13 # EcoGene EG11119 yceD # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # IntAct P0AB28 11 # InterPro IPR003772 DUF177 # Organism YCED_ECOLI Escherichia coli (strain K12) # PATRIC 32117417 VBIEscCol129921_1131 # PIR JV0047 JV0047 # Pfam PF02620 DUF177 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCED_ECOLI Uncharacterized protein YceD # RefSeq NP_415606 NC_000913.3 # RefSeq WP_001174481 NZ_LN832404.1 # SIMILARITY To H.influenzae HI_0159. {ECO 0000305}. # eggNOG COG1399 LUCA # eggNOG ENOG4105FCQ Bacteria BLAST swissprot:YCED_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCED_ECOLI BioCyc ECOL316407:JW1074-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1074-MONOMER BioCyc EcoCyc:EG11119-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11119-MONOMER COG COG1399 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1399 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M29698 http://www.ebi.ac.uk/ena/data/view/M29698 EMBL M96791 http://www.ebi.ac.uk/ena/data/view/M96791 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1109 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1109 EcoGene EG11119 http://www.ecogene.org/geneInfo.php?eg_id=EG11119 EnsemblBacteria AAC74172 http://www.ensemblgenomes.org/id/AAC74172 EnsemblBacteria AAC74172 http://www.ensemblgenomes.org/id/AAC74172 EnsemblBacteria BAA35896 http://www.ensemblgenomes.org/id/BAA35896 EnsemblBacteria BAA35896 http://www.ensemblgenomes.org/id/BAA35896 EnsemblBacteria BAA35896 http://www.ensemblgenomes.org/id/BAA35896 EnsemblBacteria b1088 http://www.ensemblgenomes.org/id/b1088 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GeneID 945650 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945650 HOGENOM HOG000258050 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000258050&db=HOGENOM6 InParanoid P0AB28 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AB28 IntAct P0AB28 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AB28* InterPro IPR003772 http://www.ebi.ac.uk/interpro/entry/IPR003772 KEGG_Gene ecj:JW1074 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1074 KEGG_Gene eco:b1088 http://www.genome.jp/dbget-bin/www_bget?eco:b1088 KEGG_Orthology KO:K07040 http://www.genome.jp/dbget-bin/www_bget?KO:K07040 OMA TLLCQRC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TLLCQRC PSORT swissprot:YCED_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCED_ECOLI PSORT-B swissprot:YCED_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCED_ECOLI PSORT2 swissprot:YCED_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCED_ECOLI Pfam PF02620 http://pfam.xfam.org/family/PF02620 Phobius swissprot:YCED_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCED_ECOLI PhylomeDB P0AB28 http://phylomedb.org/?seqid=P0AB28 ProteinModelPortal P0AB28 http://www.proteinmodelportal.org/query/uniprot/P0AB28 PubMed 1447160 http://www.ncbi.nlm.nih.gov/pubmed/1447160 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2477362 http://www.ncbi.nlm.nih.gov/pubmed/2477362 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415606 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415606 RefSeq WP_001174481 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001174481 STRING 511145.b1088 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1088&targetmode=cogs STRING COG1399 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1399&targetmode=cogs UniProtKB YCED_ECOLI http://www.uniprot.org/uniprot/YCED_ECOLI UniProtKB-AC P0AB28 http://www.uniprot.org/uniprot/P0AB28 charge swissprot:YCED_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCED_ECOLI eggNOG COG1399 http://eggnogapi.embl.de/nog_data/html/tree/COG1399 eggNOG ENOG4105FCQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FCQ epestfind swissprot:YCED_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCED_ECOLI garnier swissprot:YCED_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCED_ECOLI helixturnhelix swissprot:YCED_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCED_ECOLI hmoment swissprot:YCED_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCED_ECOLI iep swissprot:YCED_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCED_ECOLI inforesidue swissprot:YCED_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCED_ECOLI octanol swissprot:YCED_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCED_ECOLI pepcoil swissprot:YCED_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCED_ECOLI pepdigest swissprot:YCED_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCED_ECOLI pepinfo swissprot:YCED_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCED_ECOLI pepnet swissprot:YCED_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCED_ECOLI pepstats swissprot:YCED_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCED_ECOLI pepwheel swissprot:YCED_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCED_ECOLI pepwindow swissprot:YCED_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCED_ECOLI sigcleave swissprot:YCED_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCED_ECOLI ## Database ID URL or Descriptions # CDD cd03368 Ribosomal_S12 # DrugBank DB00452 Framycetin # DrugBank DB00479 Amikacin # DrugBank DB00560 Tigecycline # DrugBank DB00684 Tobramycin # DrugBank DB00798 Gentamicin # DrugBank DB00919 Spectinomycin # DrugBank DB00955 Netilmicin # DrugBank DB00994 Neomycin # DrugBank DB01082 Streptomycin # DrugBank DB01172 Kanamycin # DrugBank DB03615 Ribostamycin # DrugBank DB06696 Arbekacin # EcoGene EG10911 rpsL # FUNCTION RS12_ECOLI Cryo-EM studies suggest that S12 contacts the EF-Tu bound tRNA in the A-site during codon-recognition. This contact is most likely broken as the aminoacyl-tRNA moves into the peptidyl transferase center in the 50S subunit. # FUNCTION RS12_ECOLI Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity). {ECO 0000250}. # FUNCTION RS12_ECOLI With S4 and S5 plays an important role in translational accuracy. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0022627 cytosolic small ribosomal subunit; IDA:EcoliWiki. # GO_function GO:0000049 tRNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0003735 structural constituent of ribosome; IBA:GO_Central. # GO_function GO:0019843 rRNA binding; IDA:EcoCyc. # GO_function GO:0034336 misfolded RNA binding; IDA:EcoCyc. # GO_process GO:0000372 Group I intron splicing; IDA:EcoCyc. # GO_process GO:0006412 translation; IMP:EcoCyc. # GO_process GO:0033120 positive regulation of RNA splicing; IDA:EcoCyc. # GO_process GO:0034337 RNA folding; IDA:EcoCyc. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_function GO:0019843 rRNA binding # GOslim_process GO:0006412 translation # GOslim_process GO:0008150 biological_process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # HAMAP MF_00403_B Ribosomal_S12_B # INTERACTION RS12_ECOLI P0A8A8 rimP; NbExp=3; IntAct=EBI-543960, EBI-561065; # IntAct P0A7S3 27 # InterPro IPR005679 Ribosomal_S12_bac # InterPro IPR006032 Ribosomal_S12/S23 # InterPro IPR012340 NA-bd_OB-fold # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 M00179 Ribosome, archaea # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=13651.3; Method=MALDI; Range=2-124; Evidence={ECO:0000269|PubMed 10094780}; # MISCELLANEOUS RS12_ECOLI At least 19 substitutions or deletions in 11 codons can promote streptomycin resistance, dependence or pseudodependence; all but one of the streptomycin resistant mutations (K42R) are associated with hyperaccurate translation and thus reduced translational efficiency. # MISCELLANEOUS RS12_ECOLI The streptomycin sensitive allele is dominant to resistant alleles. # Organism RS12_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11652 PTHR11652 # PATRIC 32122116 VBIEscCol129921_3435 # PDB 1M5G Model; -; L=2-124 # PDB 1MJ1 EM; 13.00 A; O=5-123 # PDB 1ZN1 EM; 14.10 A; L=28-124 # PDB 2YKR EM; 9.80 A; L=2-124 # PDB 3DEG EM; -; D=2-124 # PDB 3EP2 EM; -; L=2-124 # PDB 3EQ3 EM; -; L=2-124 # PDB 3EQ4 EM; -; L=2-124 # PDB 3J0D EM; 11.10 A; I=2-124 # PDB 3J0E EM; 9.90 A; F=2-124 # PDB 3J9Y EM; 3.90 A; l=1-124 # PDB 3J9Z EM; 3.60 A; SL=2-124 # PDB 3JA1 EM; 3.60 A; SL=2-124 # PDB 3JBU EM; 3.64 A; L=1-124 # PDB 3JBV EM; 3.32 A; L=1-124 # PDB 3JCD EM; 3.70 A; l=1-124 # PDB 3JCE EM; 3.20 A; l=1-124 # PDB 3JCJ EM; 3.70 A; t=1-124 # PDB 3JCN EM; 4.60 A; o=1-124 # PDB 4A2I EM; 16.50 A; L=2-124 # PDB 4ADV EM; 13.50 A; L=2-124 # PDB 4U1U X-ray; 2.95 A; AL/CL=2-124 # PDB 4U1V X-ray; 3.00 A; AL/CL=2-124 # PDB 4U20 X-ray; 2.90 A; AL/CL=2-124 # PDB 4U24 X-ray; 2.90 A; AL/CL=2-124 # PDB 4U25 X-ray; 2.90 A; AL/CL=2-124 # PDB 4U26 X-ray; 2.80 A; AL/CL=2-124 # PDB 4U27 X-ray; 2.80 A; AL/CL=2-124 # PDB 4V47 EM; 12.30 A; BL=2-124 # PDB 4V48 EM; 11.50 A; BL=2-124 # PDB 4V4H X-ray; 3.46 A; AL/CL=1-124 # PDB 4V4Q X-ray; 3.46 A; AL/CL=2-124 # PDB 4V4V EM; 15.00 A; AL=23-123 # PDB 4V4W EM; 15.00 A; AL=23-123 # PDB 4V50 X-ray; 3.22 A; AL/CL=2-124 # PDB 4V52 X-ray; 3.21 A; AL/CL=2-124 # PDB 4V53 X-ray; 3.54 A; AL/CL=2-124 # PDB 4V54 X-ray; 3.30 A; AL/CL=2-124 # PDB 4V55 X-ray; 4.00 A; AL/CL=2-124 # PDB 4V56 X-ray; 3.93 A; AL/CL=2-124 # PDB 4V57 X-ray; 3.50 A; AL/CL=2-124 # PDB 4V5B X-ray; 3.74 A; BL/DL=2-124 # PDB 4V5H EM; 5.80 A; AL=2-124 # PDB 4V5Y X-ray; 4.45 A; AL/CL=2-124 # PDB 4V64 X-ray; 3.50 A; AL/CL=2-124 # PDB 4V65 EM; 9.00 A; AD=1-124 # PDB 4V66 EM; 9.00 A; AD=1-124 # PDB 4V69 EM; 6.70 A; AL=2-124 # PDB 4V6C X-ray; 3.19 A; AL/CL=1-124 # PDB 4V6D X-ray; 3.81 A; AL/CL=1-124 # PDB 4V6E X-ray; 3.71 A; AL/CL=1-124 # PDB 4V6K EM; 8.25 A; BP=1-124 # PDB 4V6L EM; 13.20 A; AP=1-124 # PDB 4V6M EM; 7.10 A; AL=2-124, AO=2-89 # PDB 4V6N EM; 12.10 A; BO=2-124 # PDB 4V6O EM; 14.70 A; AO=2-124 # PDB 4V6P EM; 13.50 A; AO=2-124 # PDB 4V6Q EM; 11.50 A; AO=2-124 # PDB 4V6R EM; 11.50 A; AO=2-124 # PDB 4V6S EM; 13.10 A; BN=2-124 # PDB 4V6T EM; 8.30 A; AL=2-124 # PDB 4V6V EM; 9.80 A; AL=2-124 # PDB 4V6Y EM; 12.00 A; AL=1-124 # PDB 4V6Z EM; 12.00 A; AL=1-124 # PDB 4V70 EM; 17.00 A; AL=1-124 # PDB 4V71 EM; 20.00 A; AL=1-124 # PDB 4V72 EM; 13.00 A; AL=1-124 # PDB 4V73 EM; 15.00 A; AL=1-124 # PDB 4V74 EM; 17.00 A; AL=1-124 # PDB 4V75 EM; 12.00 A; AL=1-124 # PDB 4V76 EM; 17.00 A; AL=1-124 # PDB 4V77 EM; 17.00 A; AL=1-124 # PDB 4V78 EM; 20.00 A; AL=1-124 # PDB 4V79 EM; 15.00 A; AL=1-124 # PDB 4V7A EM; 9.00 A; AL=1-124 # PDB 4V7B EM; 6.80 A; AL=1-124 # PDB 4V7C EM; 7.60 A; AL=2-124 # PDB 4V7D EM; 7.60 A; BL=2-124 # PDB 4V7I EM; 9.60 A; BL=1-124 # PDB 4V7S X-ray; 3.25 A; AL/CL=2-124 # PDB 4V7T X-ray; 3.19 A; AL/CL=2-124 # PDB 4V7U X-ray; 3.10 A; AL/CL=2-124 # PDB 4V7V X-ray; 3.29 A; AL/CL=2-124 # PDB 4V85 X-ray; 3.20 A; L=1-124 # PDB 4V89 X-ray; 3.70 A; AL=1-124 # PDB 4V9C X-ray; 3.30 A; AL/CL=1-124 # PDB 4V9D X-ray; 3.00 A; AL/BL=2-124 # PDB 4V9O X-ray; 2.90 A; BL/DL/FL/HL=1-124 # PDB 4V9P X-ray; 2.90 A; BL/DL/FL/HL=1-124 # PDB 4WF1 X-ray; 3.09 A; AL/CL=2-124 # PDB 4WOI X-ray; 3.00 A; AL/DL=1-124 # PDB 4WWW X-ray; 3.10 A; QL/XL=2-124 # PDB 4YBB X-ray; 2.10 A; AL/BL=2-124 # PDB 5AFI EM; 2.90 A; l=1-124 # PDB 5IQR EM; 3.00 A; q=1-124 # PDB 5IT8 X-ray; 3.12 A; AL/BL=2-124 # PDB 5J5B X-ray; 2.80 A; AL/BL=2-124 # PDB 5J7L X-ray; 3.00 A; AL/BL=2-124 # PDB 5J88 X-ray; 3.32 A; AL/BL=2-124 # PDB 5J8A X-ray; 3.10 A; AL/BL=2-124 # PDB 5J91 X-ray; 2.96 A; AL/BL=2-124 # PDB 5JC9 X-ray; 3.03 A; AL/BL=2-124 # PDB 5JTE EM; 3.60 A; AL=1-124 # PDB 5JU8 EM; 3.60 A; AL=1-124 # PDB 5KCR EM; 3.60 A; 1l=1-124 # PDB 5KCS EM; 3.90 A; 1l=1-124 # PDB 5KPS EM; 3.90 A; 17=1-124 # PDB 5KPV EM; 4.10 A; 16=1-124 # PDB 5KPW EM; 3.90 A; 16=1-124 # PDB 5KPX EM; 3.90 A; 16=1-124 # PDB 5L3P EM; 3.70 A; l=1-124 # PIR S13738 R3EC12 # PIRSF PIRSF002133 Ribosomal_S12/S23 # PRINTS PR01034 RIBOSOMALS12 # PROSITE PS00055 RIBOSOMAL_S12 # Pfam PF00164 Ribosom_S12_S23 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RS12_ECOLI 30S ribosomal protein S12 # RefSeq NP_417801 NC_000913.3 # RefSeq WP_000246815 NZ_CP011343.2 # SIMILARITY Belongs to the ribosomal protein S12P family. {ECO 0000305}. # SUBUNIT Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex (By similarity). {ECO 0000250}. # SUPFAM SSF50249 SSF50249 # TIGRFAMs TIGR00981 rpsL_bact # eggNOG COG0048 LUCA BLAST swissprot:RS12_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RS12_ECOLI BioCyc ECOL316407:JW3304-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3304-MONOMER BioCyc EcoCyc:EG10911-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10911-MONOMER BioCyc MetaCyc:EG10911-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10911-MONOMER COG COG0048 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0048 DIP DIP-35806N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35806N DOI 10.1002/pro.5560050816 http://dx.doi.org/10.1002/pro.5560050816 DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1007/BF00299141 http://dx.doi.org/10.1007/BF00299141 DOI 10.1016/0014-5793(77)80004-5 http://dx.doi.org/10.1016/0014-5793(77)80004-5 DOI 10.1016/0022-2836(89)90509-3 http://dx.doi.org/10.1016/0022-2836(89)90509-3 DOI 10.1016/0092-8674(78)90096-X http://dx.doi.org/10.1016/0092-8674(78)90096-X DOI 10.1016/S0092-8674(03)00427-6 http://dx.doi.org/10.1016/S0092-8674(03)00427-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb841 http://dx.doi.org/10.1038/nsb841 DOI 10.1038/nsb859 http://dx.doi.org/10.1038/nsb859 DOI 10.1046/j.1365-2958.1999.01307.x http://dx.doi.org/10.1046/j.1365-2958.1999.01307.x DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/emboj/cdf326 http://dx.doi.org/10.1093/emboj/cdf326 DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DisProt DP00145 http://www.disprot.org/protein.php?id=DP00145 DrugBank DB00452 http://www.drugbank.ca/drugs/DB00452 DrugBank DB00479 http://www.drugbank.ca/drugs/DB00479 DrugBank DB00560 http://www.drugbank.ca/drugs/DB00560 DrugBank DB00684 http://www.drugbank.ca/drugs/DB00684 DrugBank DB00798 http://www.drugbank.ca/drugs/DB00798 DrugBank DB00919 http://www.drugbank.ca/drugs/DB00919 DrugBank DB00955 http://www.drugbank.ca/drugs/DB00955 DrugBank DB00994 http://www.drugbank.ca/drugs/DB00994 DrugBank DB01082 http://www.drugbank.ca/drugs/DB01082 DrugBank DB01172 http://www.drugbank.ca/drugs/DB01172 DrugBank DB03615 http://www.drugbank.ca/drugs/DB03615 DrugBank DB06696 http://www.drugbank.ca/drugs/DB06696 EMBL AF312716 http://www.ebi.ac.uk/ena/data/view/AF312716 EMBL AF312717 http://www.ebi.ac.uk/ena/data/view/AF312717 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01688 http://www.ebi.ac.uk/ena/data/view/J01688 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL V00354 http://www.ebi.ac.uk/ena/data/view/V00354 EMBL V00355 http://www.ebi.ac.uk/ena/data/view/V00355 EchoBASE EB0904 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0904 EcoGene EG10911 http://www.ecogene.org/geneInfo.php?eg_id=EG10911 EnsemblBacteria AAC76367 http://www.ensemblgenomes.org/id/AAC76367 EnsemblBacteria AAC76367 http://www.ensemblgenomes.org/id/AAC76367 EnsemblBacteria BAE77949 http://www.ensemblgenomes.org/id/BAE77949 EnsemblBacteria BAE77949 http://www.ensemblgenomes.org/id/BAE77949 EnsemblBacteria BAE77949 http://www.ensemblgenomes.org/id/BAE77949 EnsemblBacteria b3342 http://www.ensemblgenomes.org/id/b3342 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0022627 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022627 GO_function GO:0000049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000049 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GO_function GO:0034336 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034336 GO_process GO:0000372 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000372 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GO_process GO:0033120 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033120 GO_process GO:0034337 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034337 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 24912032 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24912032 GeneID 947845 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947845 HAMAP MF_00403_B http://hamap.expasy.org/unirule/MF_00403_B HOGENOM HOG000040063 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000040063&db=HOGENOM6 InParanoid P0A7S3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7S3 IntAct P0A7S3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7S3* InterPro IPR005679 http://www.ebi.ac.uk/interpro/entry/IPR005679 InterPro IPR006032 http://www.ebi.ac.uk/interpro/entry/IPR006032 InterPro IPR012340 http://www.ebi.ac.uk/interpro/entry/IPR012340 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW3304 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3304 KEGG_Gene eco:b3342 http://www.genome.jp/dbget-bin/www_bget?eco:b3342 KEGG_Orthology KO:K02950 http://www.genome.jp/dbget-bin/www_bget?KO:K02950 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 OMA KSKVPAM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KSKVPAM PANTHER PTHR11652 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11652 PDB 1M5G http://www.ebi.ac.uk/pdbe-srv/view/entry/1M5G PDB 1MJ1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1MJ1 PDB 1ZN1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZN1 PDB 2YKR http://www.ebi.ac.uk/pdbe-srv/view/entry/2YKR PDB 3DEG http://www.ebi.ac.uk/pdbe-srv/view/entry/3DEG PDB 3EP2 http://www.ebi.ac.uk/pdbe-srv/view/entry/3EP2 PDB 3EQ3 http://www.ebi.ac.uk/pdbe-srv/view/entry/3EQ3 PDB 3EQ4 http://www.ebi.ac.uk/pdbe-srv/view/entry/3EQ4 PDB 3J0D http://www.ebi.ac.uk/pdbe-srv/view/entry/3J0D PDB 3J0E http://www.ebi.ac.uk/pdbe-srv/view/entry/3J0E PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 4A2I http://www.ebi.ac.uk/pdbe-srv/view/entry/4A2I PDB 4ADV http://www.ebi.ac.uk/pdbe-srv/view/entry/4ADV PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4V47 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V47 PDB 4V48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V48 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 1M5G http://www.ebi.ac.uk/pdbsum/1M5G PDBsum 1MJ1 http://www.ebi.ac.uk/pdbsum/1MJ1 PDBsum 1ZN1 http://www.ebi.ac.uk/pdbsum/1ZN1 PDBsum 2YKR http://www.ebi.ac.uk/pdbsum/2YKR PDBsum 3DEG http://www.ebi.ac.uk/pdbsum/3DEG PDBsum 3EP2 http://www.ebi.ac.uk/pdbsum/3EP2 PDBsum 3EQ3 http://www.ebi.ac.uk/pdbsum/3EQ3 PDBsum 3EQ4 http://www.ebi.ac.uk/pdbsum/3EQ4 PDBsum 3J0D http://www.ebi.ac.uk/pdbsum/3J0D PDBsum 3J0E http://www.ebi.ac.uk/pdbsum/3J0E PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 4A2I http://www.ebi.ac.uk/pdbsum/4A2I PDBsum 4ADV http://www.ebi.ac.uk/pdbsum/4ADV PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4V47 http://www.ebi.ac.uk/pdbsum/4V47 PDBsum 4V48 http://www.ebi.ac.uk/pdbsum/4V48 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PRINTS PR01034 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01034 PROSITE PS00055 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00055 PSORT swissprot:RS12_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RS12_ECOLI PSORT-B swissprot:RS12_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RS12_ECOLI PSORT2 swissprot:RS12_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RS12_ECOLI Pfam PF00164 http://pfam.xfam.org/family/PF00164 Phobius swissprot:RS12_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RS12_ECOLI PhylomeDB P0A7S3 http://phylomedb.org/?seqid=P0A7S3 ProteinModelPortal P0A7S3 http://www.proteinmodelportal.org/query/uniprot/P0A7S3 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 10209746 http://www.ncbi.nlm.nih.gov/pubmed/10209746 PubMed 12093756 http://www.ncbi.nlm.nih.gov/pubmed/12093756 PubMed 12244297 http://www.ncbi.nlm.nih.gov/pubmed/12244297 PubMed 12379845 http://www.ncbi.nlm.nih.gov/pubmed/12379845 PubMed 12809609 http://www.ncbi.nlm.nih.gov/pubmed/12809609 PubMed 151587 http://www.ncbi.nlm.nih.gov/pubmed/151587 PubMed 1552908 http://www.ncbi.nlm.nih.gov/pubmed/1552908 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 2477554 http://www.ncbi.nlm.nih.gov/pubmed/2477554 PubMed 320034 http://www.ncbi.nlm.nih.gov/pubmed/320034 PubMed 6989816 http://www.ncbi.nlm.nih.gov/pubmed/6989816 PubMed 7556101 http://www.ncbi.nlm.nih.gov/pubmed/7556101 PubMed 8844851 http://www.ncbi.nlm.nih.gov/pubmed/8844851 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417801 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417801 RefSeq WP_000246815 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000246815 SMR P0A7S3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7S3 STRING 511145.b3342 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3342&targetmode=cogs STRING COG0048 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0048&targetmode=cogs SUPFAM SSF50249 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50249 TIGRFAMs TIGR00981 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00981 UniProtKB RS12_ECOLI http://www.uniprot.org/uniprot/RS12_ECOLI UniProtKB-AC P0A7S3 http://www.uniprot.org/uniprot/P0A7S3 charge swissprot:RS12_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RS12_ECOLI eggNOG COG0048 http://eggnogapi.embl.de/nog_data/html/tree/COG0048 epestfind swissprot:RS12_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RS12_ECOLI garnier swissprot:RS12_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RS12_ECOLI helixturnhelix swissprot:RS12_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RS12_ECOLI hmoment swissprot:RS12_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RS12_ECOLI iep swissprot:RS12_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RS12_ECOLI inforesidue swissprot:RS12_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RS12_ECOLI octanol swissprot:RS12_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RS12_ECOLI pepcoil swissprot:RS12_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RS12_ECOLI pepdigest swissprot:RS12_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RS12_ECOLI pepinfo swissprot:RS12_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RS12_ECOLI pepnet swissprot:RS12_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RS12_ECOLI pepstats swissprot:RS12_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RS12_ECOLI pepwheel swissprot:RS12_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RS12_ECOLI pepwindow swissprot:RS12_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RS12_ECOLI sigcleave swissprot:RS12_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RS12_ECOLI ## Database ID URL or Descriptions # BioGrid 4259734 5 # EcoGene EG12321 yadH # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006810 transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006810 transport # InterPro IPR000412 ABC_2_transport # InterPro IPR013525 ABC_2_trans # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00248 Putative antibiotic transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism YADH_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30413 PTHR30413 # PATRIC 32115359 VBIEscCol129921_0131 # PIR H64735 H64735 # PIRSF PIRSF006648 DrrB # PRINTS PR00164 ABC2TRNSPORT # PROSITE PS51012 ABC_TM2 # Pfam PF01061 ABC2_membrane # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YADH_ECOLI Inner membrane transport permease YadH # RefSeq NP_414670 NC_000913.3 # RefSeq WP_000972203 NZ_LN832404.1 # SIMILARITY Belongs to the ABC-2 integral membrane protein family. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-2 domain. {ECO:0000255|PROSITE-ProRule PRU00442}. # SUBCELLULAR LOCATION YADH_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 3.A.1.105.17 the atp-binding cassette (abc) superfamily # eggNOG COG0842 LUCA # eggNOG ENOG4105E3A Bacteria BLAST swissprot:YADH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YADH_ECOLI BioCyc ECOL316407:JW0124-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0124-MONOMER BioCyc EcoCyc:YADH-MONOMER http://biocyc.org/getid?id=EcoCyc:YADH-MONOMER COG COG0842 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0842 COG COG1277 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1277 COG COG1668 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1668 COG COG3559 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3559 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2226 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2226 EcoGene EG12321 http://www.ecogene.org/geneInfo.php?eg_id=EG12321 EnsemblBacteria AAC73239 http://www.ensemblgenomes.org/id/AAC73239 EnsemblBacteria AAC73239 http://www.ensemblgenomes.org/id/AAC73239 EnsemblBacteria BAB96705 http://www.ensemblgenomes.org/id/BAB96705 EnsemblBacteria BAB96705 http://www.ensemblgenomes.org/id/BAB96705 EnsemblBacteria BAB96705 http://www.ensemblgenomes.org/id/BAB96705 EnsemblBacteria b0128 http://www.ensemblgenomes.org/id/b0128 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 944836 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944836 HOGENOM HOG000252768 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000252768&db=HOGENOM6 InParanoid P0AFN6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFN6 InterPro IPR000412 http://www.ebi.ac.uk/interpro/entry/IPR000412 InterPro IPR013525 http://www.ebi.ac.uk/interpro/entry/IPR013525 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0124 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0124 KEGG_Gene eco:b0128 http://www.genome.jp/dbget-bin/www_bget?eco:b0128 KEGG_Orthology KO:K09686 http://www.genome.jp/dbget-bin/www_bget?KO:K09686 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA FQVHSWL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FQVHSWL PANTHER PTHR30413 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30413 PRINTS PR00164 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00164 PROSITE PS51012 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51012 PSORT swissprot:YADH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YADH_ECOLI PSORT-B swissprot:YADH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YADH_ECOLI PSORT2 swissprot:YADH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YADH_ECOLI Pfam PF01061 http://pfam.xfam.org/family/PF01061 Phobius swissprot:YADH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YADH_ECOLI PhylomeDB P0AFN6 http://phylomedb.org/?seqid=P0AFN6 ProteinModelPortal P0AFN6 http://www.proteinmodelportal.org/query/uniprot/P0AFN6 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414670 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414670 RefSeq WP_000972203 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000972203 STRING 511145.b0128 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0128&targetmode=cogs STRING COG0842 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0842&targetmode=cogs STRING COG1277 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1277&targetmode=cogs STRING COG1668 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1668&targetmode=cogs STRING COG3559 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3559&targetmode=cogs TCDB 3.A.1.105.17 http://www.tcdb.org/search/result.php?tc=3.A.1.105.17 UniProtKB YADH_ECOLI http://www.uniprot.org/uniprot/YADH_ECOLI UniProtKB-AC P0AFN6 http://www.uniprot.org/uniprot/P0AFN6 charge swissprot:YADH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YADH_ECOLI eggNOG COG0842 http://eggnogapi.embl.de/nog_data/html/tree/COG0842 eggNOG ENOG4105E3A http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E3A epestfind swissprot:YADH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YADH_ECOLI garnier swissprot:YADH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YADH_ECOLI helixturnhelix swissprot:YADH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YADH_ECOLI hmoment swissprot:YADH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YADH_ECOLI iep swissprot:YADH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YADH_ECOLI inforesidue swissprot:YADH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YADH_ECOLI octanol swissprot:YADH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YADH_ECOLI pepcoil swissprot:YADH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YADH_ECOLI pepdigest swissprot:YADH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YADH_ECOLI pepinfo swissprot:YADH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YADH_ECOLI pepnet swissprot:YADH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YADH_ECOLI pepstats swissprot:YADH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YADH_ECOLI pepwheel swissprot:YADH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YADH_ECOLI pepwindow swissprot:YADH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YADH_ECOLI sigcleave swissprot:YADH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YADH_ECOLI ## Database ID URL or Descriptions # AltName UPP_ECOLI UMP pyrophosphorylase # AltName UPP_ECOLI UPRTase # BIOPHYSICOCHEMICAL PROPERTIES UPP_ECOLI Kinetic parameters KM=0.53 uM for uracil {ECO 0000269|PubMed 10079076}; KM=58 uM for 5-phospho-alpha-D-ribose 1-diphosphate {ECO 0000269|PubMed 10079076}; # BioGrid 4261438 7 # CATALYTIC ACTIVITY UMP + diphosphate = uracil + 5-phospho-alpha- D-ribose 1-diphosphate. {ECO:0000269|PubMed 8856065}. # CDD cd06223 PRTases_typeI # COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI 18420; Note=Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg- PRPP.; # ENZYME REGULATION Allosterically activated by GTP. {ECO:0000269|PubMed 8856065}. # EcoGene EG11332 upp # FUNCTION UPP_ECOLI Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0004845 uracil phosphoribosyltransferase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0004849 uridine kinase activity; IBA:GO_Central. # GO_function GO:0005525 GTP binding; IEA:UniProtKB-KW. # GO_function GO:0042802 identical protein binding; IPI:IntAct. # GO_process GO:0006206 pyrimidine nucleobase metabolic process; IBA:GO_Central. # GO_process GO:0006223 uracil salvage; IEA:InterPro. # GO_process GO:0043097 pyrimidine nucleoside salvage; IBA:GO_Central. # GO_process GO:0044206 UMP salvage; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.2020 -; 1. # HAMAP MF_01218_B Upp_B # INDUCTION UPP_ECOLI By pyrimidine starvation. # INTERACTION UPP_ECOLI Self; NbExp=5; IntAct=EBI-909572, EBI-909572; # IntAct P0A8F0 5 # InterPro IPR000836 PRibTrfase_dom # InterPro IPR005765 Ura_phspho_trans # InterPro IPR029057 PRTase-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00240 Pyrimidine metabolism # Organism UPP_ECOLI Escherichia coli (strain K12) # PATHWAY Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil step 1/1. # PATRIC 32120383 VBIEscCol129921_2594 # PDB 2EHJ X-ray; 2.80 A; A/B/C/D=2-208 # PIR A65026 A65026 # Pfam PF14681 UPRTase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UPP_ECOLI Uracil phosphoribosyltransferase # RefSeq NP_416993 NC_000913.3 # RefSeq WP_001295473 NZ_LN832404.1 # SIMILARITY Belongs to the UPRTase family. {ECO 0000305}. # SUBUNIT Homodimer or homotrimer in the absence of substrates, and homopentamer or homohexamer in the presence of substrates. {ECO:0000269|PubMed 8856065}. # SUPFAM SSF53271 SSF53271 # TIGRFAMs TIGR01091 upp # UniPathway UPA00574 UER00636 # eggNOG COG0035 LUCA # eggNOG ENOG4105CZ5 Bacteria BLAST swissprot:UPP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UPP_ECOLI BioCyc ECOL316407:JW2483-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2483-MONOMER BioCyc EcoCyc:URACIL-PRIBOSYLTRANS-MONOMER http://biocyc.org/getid?id=EcoCyc:URACIL-PRIBOSYLTRANS-MONOMER BioCyc MetaCyc:URACIL-PRIBOSYLTRANS-MONOMER http://biocyc.org/getid?id=MetaCyc:URACIL-PRIBOSYLTRANS-MONOMER COG COG0035 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0035 DIP DIP-36228N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36228N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1021/bi982279q http://dx.doi.org/10.1021/bi982279q DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1432-1033.1992.tb16604.x http://dx.doi.org/10.1111/j.1432-1033.1992.tb16604.x DOI 10.1111/j.1432-1033.1996.0637h.x http://dx.doi.org/10.1111/j.1432-1033.1996.0637h.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.4.2.9 http://www.genome.jp/dbget-bin/www_bget?EC:2.4.2.9 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X57104 http://www.ebi.ac.uk/ena/data/view/X57104 ENZYME 2.4.2.9 http://enzyme.expasy.org/EC/2.4.2.9 EchoBASE EB1308 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1308 EcoGene EG11332 http://www.ecogene.org/geneInfo.php?eg_id=EG11332 EnsemblBacteria AAC75551 http://www.ensemblgenomes.org/id/AAC75551 EnsemblBacteria AAC75551 http://www.ensemblgenomes.org/id/AAC75551 EnsemblBacteria BAA16386 http://www.ensemblgenomes.org/id/BAA16386 EnsemblBacteria BAA16386 http://www.ensemblgenomes.org/id/BAA16386 EnsemblBacteria BAA16386 http://www.ensemblgenomes.org/id/BAA16386 EnsemblBacteria b2498 http://www.ensemblgenomes.org/id/b2498 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0004845 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004845 GO_function GO:0004849 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004849 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0006206 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006206 GO_process GO:0006223 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006223 GO_process GO:0043097 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043097 GO_process GO:0044206 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044206 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.2020 http://www.cathdb.info/version/latest/superfamily/3.40.50.2020 GeneID 946979 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946979 HAMAP MF_01218_B http://hamap.expasy.org/unirule/MF_01218_B HOGENOM HOG000262754 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000262754&db=HOGENOM6 InParanoid P0A8F0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8F0 IntAct P0A8F0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8F0* IntEnz 2.4.2.9 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.2.9 InterPro IPR000836 http://www.ebi.ac.uk/interpro/entry/IPR000836 InterPro IPR005765 http://www.ebi.ac.uk/interpro/entry/IPR005765 InterPro IPR029057 http://www.ebi.ac.uk/interpro/entry/IPR029057 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2483 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2483 KEGG_Gene eco:b2498 http://www.genome.jp/dbget-bin/www_bget?eco:b2498 KEGG_Orthology KO:K00761 http://www.genome.jp/dbget-bin/www_bget?KO:K00761 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Reaction rn:R00966 http://www.genome.jp/dbget-bin/www_bget?rn:R00966 OMA VTVIDHP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VTVIDHP PDB 2EHJ http://www.ebi.ac.uk/pdbe-srv/view/entry/2EHJ PDBsum 2EHJ http://www.ebi.ac.uk/pdbsum/2EHJ PSORT swissprot:UPP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UPP_ECOLI PSORT-B swissprot:UPP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UPP_ECOLI PSORT2 swissprot:UPP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UPP_ECOLI Pfam PF14681 http://pfam.xfam.org/family/PF14681 Phobius swissprot:UPP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UPP_ECOLI PhylomeDB P0A8F0 http://phylomedb.org/?seqid=P0A8F0 ProteinModelPortal P0A8F0 http://www.proteinmodelportal.org/query/uniprot/P0A8F0 PubMed 10079076 http://www.ncbi.nlm.nih.gov/pubmed/10079076 PubMed 1371255 http://www.ncbi.nlm.nih.gov/pubmed/1371255 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8856065 http://www.ncbi.nlm.nih.gov/pubmed/8856065 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_416993 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416993 RefSeq WP_001295473 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295473 SMR P0A8F0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8F0 STRING 511145.b2498 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2498&targetmode=cogs STRING COG0035 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0035&targetmode=cogs SUPFAM SSF53271 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53271 SWISS-2DPAGE P0A8F0 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A8F0 TIGRFAMs TIGR01091 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01091 UniProtKB UPP_ECOLI http://www.uniprot.org/uniprot/UPP_ECOLI UniProtKB-AC P0A8F0 http://www.uniprot.org/uniprot/P0A8F0 charge swissprot:UPP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UPP_ECOLI eggNOG COG0035 http://eggnogapi.embl.de/nog_data/html/tree/COG0035 eggNOG ENOG4105CZ5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CZ5 epestfind swissprot:UPP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UPP_ECOLI garnier swissprot:UPP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UPP_ECOLI helixturnhelix swissprot:UPP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UPP_ECOLI hmoment swissprot:UPP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UPP_ECOLI iep swissprot:UPP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UPP_ECOLI inforesidue swissprot:UPP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UPP_ECOLI octanol swissprot:UPP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UPP_ECOLI pepcoil swissprot:UPP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UPP_ECOLI pepdigest swissprot:UPP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UPP_ECOLI pepinfo swissprot:UPP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UPP_ECOLI pepnet swissprot:UPP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UPP_ECOLI pepstats swissprot:UPP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UPP_ECOLI pepwheel swissprot:UPP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UPP_ECOLI pepwindow swissprot:UPP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UPP_ECOLI sigcleave swissprot:UPP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UPP_ECOLI ## Database ID URL or Descriptions # BioGrid 4263150 4 # EcoGene EG14206 yfgJ # Gene3D 2.10.290.10 -; 1. # InterPro IPR010807 DUF1407 # InterPro IPR029037 YfgJ-like # Organism YFGJ_ECOLI Escherichia coli (strain K12) # PATRIC 32120413 VBIEscCol129921_2609 # PDB 2JNE NMR; -; A=1-71 # PIR E65027 E65027 # Pfam PF07191 zinc-ribbons_6 # ProDom PD060428 DUF1407 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFGJ_ECOLI Uncharacterized protein YfgJ # RefSeq NP_417005 NC_000913.3 # RefSeq WP_001301158 NZ_LN832404.1 # SUPFAM SSF161187 SSF161187 # eggNOG ENOG4105VPD Bacteria # eggNOG ENOG41123NZ LUCA BLAST swissprot:YFGJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFGJ_ECOLI BioCyc ECOL316407:JW5402-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5402-MONOMER BioCyc EcoCyc:G7318-MONOMER http://biocyc.org/getid?id=EcoCyc:G7318-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3958 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3958 EcoGene EG14206 http://www.ecogene.org/geneInfo.php?eg_id=EG14206 EnsemblBacteria AAC75563 http://www.ensemblgenomes.org/id/AAC75563 EnsemblBacteria AAC75563 http://www.ensemblgenomes.org/id/AAC75563 EnsemblBacteria BAE76728 http://www.ensemblgenomes.org/id/BAE76728 EnsemblBacteria BAE76728 http://www.ensemblgenomes.org/id/BAE76728 EnsemblBacteria BAE76728 http://www.ensemblgenomes.org/id/BAE76728 EnsemblBacteria b2510 http://www.ensemblgenomes.org/id/b2510 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 2.10.290.10 http://www.cathdb.info/version/latest/superfamily/2.10.290.10 GeneID 946984 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946984 HOGENOM HOG000276155 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276155&db=HOGENOM6 InterPro IPR010807 http://www.ebi.ac.uk/interpro/entry/IPR010807 InterPro IPR029037 http://www.ebi.ac.uk/interpro/entry/IPR029037 KEGG_Gene ecj:JW5402 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5402 KEGG_Gene eco:b2510 http://www.genome.jp/dbget-bin/www_bget?eco:b2510 OMA PECHKPL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PECHKPL PDB 2JNE http://www.ebi.ac.uk/pdbe-srv/view/entry/2JNE PDBsum 2JNE http://www.ebi.ac.uk/pdbsum/2JNE PSORT swissprot:YFGJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFGJ_ECOLI PSORT-B swissprot:YFGJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFGJ_ECOLI PSORT2 swissprot:YFGJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFGJ_ECOLI Pfam PF07191 http://pfam.xfam.org/family/PF07191 Phobius swissprot:YFGJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFGJ_ECOLI ProteinModelPortal P76575 http://www.proteinmodelportal.org/query/uniprot/P76575 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417005 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417005 RefSeq WP_001301158 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001301158 SMR P76575 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76575 STRING 511145.b2510 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2510&targetmode=cogs SUPFAM SSF161187 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161187 UniProtKB YFGJ_ECOLI http://www.uniprot.org/uniprot/YFGJ_ECOLI UniProtKB-AC P76575 http://www.uniprot.org/uniprot/P76575 charge swissprot:YFGJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFGJ_ECOLI eggNOG ENOG4105VPD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VPD eggNOG ENOG41123NZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG41123NZ epestfind swissprot:YFGJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFGJ_ECOLI garnier swissprot:YFGJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFGJ_ECOLI helixturnhelix swissprot:YFGJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFGJ_ECOLI hmoment swissprot:YFGJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFGJ_ECOLI iep swissprot:YFGJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFGJ_ECOLI inforesidue swissprot:YFGJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFGJ_ECOLI octanol swissprot:YFGJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFGJ_ECOLI pepcoil swissprot:YFGJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFGJ_ECOLI pepdigest swissprot:YFGJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFGJ_ECOLI pepinfo swissprot:YFGJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFGJ_ECOLI pepnet swissprot:YFGJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFGJ_ECOLI pepstats swissprot:YFGJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFGJ_ECOLI pepwheel swissprot:YFGJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFGJ_ECOLI pepwindow swissprot:YFGJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFGJ_ECOLI sigcleave swissprot:YFGJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFGJ_ECOLI ## Database ID URL or Descriptions # AltName 5'-deoxyribonucleotidase {ECO:0000255|HAMAP-Rule MF_01100} # AltName Nucleoside 5'-monophosphate phosphohydrolase {ECO:0000255|HAMAP-Rule MF_01100} # BIOPHYSICOCHEMICAL PROPERTIES 5DNU_ECOLI Kinetic parameters KM=0.012 mM for 5'-dAMP {ECO 0000269|PubMed 15489502, ECO 0000269|PubMed 18353368}; KM=0.047 mM for 5'-dGMP {ECO 0000269|PubMed 15489502, ECO 0000269|PubMed 18353368}; KM=0.008 mM for 5'-dTMP {ECO 0000269|PubMed 15489502, ECO 0000269|PubMed 18353368}; KM=0.020 mM for 5'-dUMP {ECO 0000269|PubMed 15489502, ECO 0000269|PubMed 18353368}; KM=0.017 mM for 5'-dIMP {ECO 0000269|PubMed 15489502, ECO 0000269|PubMed 18353368}; KM=0.036 mM for 5'-dCMP {ECO 0000269|PubMed 15489502, ECO 0000269|PubMed 18353368}; KM=2.09 mM for pNPP {ECO 0000269|PubMed 15489502, ECO 0000269|PubMed 18353368}; Vmax=0.71 umol/min/mg enzyme with 5'-dAMP as substrate {ECO 0000269|PubMed 15489502, ECO 0000269|PubMed 18353368}; Vmax=0.46 umol/min/mg enzyme with 5'-dGMP as substrate {ECO 0000269|PubMed 15489502, ECO 0000269|PubMed 18353368}; Vmax=0.37 umol/min/mg enzyme with 5'-dTMP as substrate {ECO 0000269|PubMed 15489502, ECO 0000269|PubMed 18353368}; Vmax=0.54 umol/min/mg enzyme with 5'-dUMP as substrate {ECO 0000269|PubMed 15489502, ECO 0000269|PubMed 18353368}; Vmax=0.56 umol/min/mg enzyme with 5'-dIMP as substrate {ECO 0000269|PubMed 15489502, ECO 0000269|PubMed 18353368}; Vmax=0.53 umol/min/mg enzyme with 5'-dCMP as substrate {ECO 0000269|PubMed 15489502, ECO 0000269|PubMed 18353368}; Vmax=1.32 umol/min/mg enzyme with pNPP as substrate {ECO 0000269|PubMed 15489502, ECO 0000269|PubMed 18353368}; pH dependence Optimum pH is 8.0. {ECO 0000269|PubMed 15489502, ECO 0000269|PubMed 18353368}; # BRENDA 3.1.3 2026 # BRENDA 3.1.3.89 2026 # BioGrid 4262969 19 # CATALYTIC ACTIVITY 5DNU_ECOLI A 2'-deoxyribonucleoside 5'-monophosphate + H(2)O = a 2'-deoxyribonucleoside + phosphate. {ECO 0000255|HAMAP- Rule MF_01100, ECO 0000269|PubMed 15489502, ECO 0000269|PubMed 18353368}. # COFACTOR 5DNU_ECOLI Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000269|PubMed 15489502}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 15489502}; Name=Cu(2+); Xref=ChEBI CHEBI 29036; Evidence={ECO 0000269|PubMed 15489502}; Note=A divalent metal cation. Highest activity with Co(2+), followed by Mn(2+) and Cu(2+). {ECO 0000269|PubMed 15489502}; # ENZYME REGULATION Inhibited by both ribo- and deoxyribonucleoside di- and triphosphates. {ECO:0000269|PubMed 15489502}. # EcoGene EG14102 yfbR # FUNCTION 5DNU_ECOLI Essential component of the deoxycytidine triphosphate (dCTP) pathway for de novo synthesis of thymidylate. Catalyzes the strictly specific dephosphorylation of 2'-deoxyribonucleoside 5'- monophosphates (dAMP, dGMP, dTMP, dUMP, dIMP and dCMP) and does not dephosphorylate 5'-ribonucleotides or ribonucleoside 3'- monophosphates. {ECO 0000269|PubMed 15489502, ECO 0000269|PubMed 17827303, ECO 0000269|PubMed 18353368}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0000166 nucleotide binding; IEA:UniProtKB-KW. # GO_function GO:0008252 nucleotidase activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0050897 cobalt ion binding; IDA:EcoCyc. # GO_process GO:0006226 dUMP biosynthetic process; IMP:EcoCyc. # GO_process GO:0010139 pyrimidine deoxyribonucleotide salvage; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.3210.10 -; 1. # HAMAP MF_01100 5DNU # IntAct P76491 2 # InterPro IPR003607 HD/PDEase_dom # InterPro IPR006674 HD_domain # InterPro IPR022971 YfbR # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00240 Pyrimidine metabolism # KEGG_Pathway ko00760 Nicotinate and nicotinamide metabolism # Organism 5DNU_ECOLI Escherichia coli (strain K12) # PATRIC 32119951 VBIEscCol129921_2385 # PDB 2PAQ X-ray; 2.10 A; A/B=1-199 # PDB 2PAR X-ray; 2.10 A; A/B=1-199 # PDB 2PAU X-ray; 2.10 A; A/B=1-199 # PIR A65001 A65001 # Pfam PF13023 HD_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 5'-deoxynucleotidase YfbR {ECO:0000255|HAMAP-Rule MF_01100} # RefSeq NP_416794 NC_000913.3 # RefSeq WP_000813859 NZ_LN832404.1 # SIMILARITY Belongs to the 5DNU family. {ECO:0000255|HAMAP- Rule MF_01100}. # SIMILARITY Contains 1 HD domain. {ECO:0000255|HAMAP- Rule MF_01100}. # SMART SM00471 HDc # SUBCELLULAR LOCATION 5DNU_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_01100}. # SUBUNIT 5DNU_ECOLI Homodimer. {ECO 0000255|HAMAP-Rule MF_01100, ECO 0000269|PubMed 15489502, ECO 0000269|PubMed 18353368}. # eggNOG COG1896 LUCA # eggNOG ENOG4105DK2 Bacteria BLAST swissprot:5DNU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:5DNU_ECOLI BioCyc ECOL316407:JW2288-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2288-MONOMER BioCyc EcoCyc:G7185-MONOMER http://biocyc.org/getid?id=EcoCyc:G7185-MONOMER BioCyc MetaCyc:G7185-MONOMER http://biocyc.org/getid?id=MetaCyc:G7185-MONOMER COG COG1896 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1896 DIP DIP-28107N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-28107N DOI 10.1016/j.jmb.2008.02.036 http://dx.doi.org/10.1016/j.jmb.2008.02.036 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M411023200 http://dx.doi.org/10.1074/jbc.M411023200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00461-07 http://dx.doi.org/10.1128/JB.00461-07 EC_number EC:3.1.3.89 {ECO:0000255|HAMAP-Rule:MF_01100} http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.89 {ECO:0000255|HAMAP-Rule:MF_01100} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.3.89 {ECO:0000255|HAMAP-Rule:MF_01100} http://enzyme.expasy.org/EC/3.1.3.89 {ECO:0000255|HAMAP-Rule:MF_01100} EchoBASE EB3855 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3855 EcoGene EG14102 http://www.ecogene.org/geneInfo.php?eg_id=EG14102 EnsemblBacteria AAC75351 http://www.ensemblgenomes.org/id/AAC75351 EnsemblBacteria AAC75351 http://www.ensemblgenomes.org/id/AAC75351 EnsemblBacteria BAE76684 http://www.ensemblgenomes.org/id/BAE76684 EnsemblBacteria BAE76684 http://www.ensemblgenomes.org/id/BAE76684 EnsemblBacteria BAE76684 http://www.ensemblgenomes.org/id/BAE76684 EnsemblBacteria b2291 http://www.ensemblgenomes.org/id/b2291 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000166 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000166 GO_function GO:0008252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008252 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0050897 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050897 GO_process GO:0006226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006226 GO_process GO:0010139 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010139 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.3210.10 http://www.cathdb.info/version/latest/superfamily/1.10.3210.10 GeneID 946771 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946771 HAMAP MF_01100 http://hamap.expasy.org/unirule/MF_01100 HOGENOM HOG000276964 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276964&db=HOGENOM6 InParanoid P76491 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76491 IntAct P76491 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76491* IntEnz 3.1.3.89 {ECO:0000255|HAMAP-Rule:MF_01100} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.89 {ECO:0000255|HAMAP-Rule:MF_01100} InterPro IPR003607 http://www.ebi.ac.uk/interpro/entry/IPR003607 InterPro IPR006674 http://www.ebi.ac.uk/interpro/entry/IPR006674 InterPro IPR022971 http://www.ebi.ac.uk/interpro/entry/IPR022971 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2288 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2288 KEGG_Gene eco:b2291 http://www.genome.jp/dbget-bin/www_bget?eco:b2291 KEGG_Orthology KO:K08722 http://www.genome.jp/dbget-bin/www_bget?KO:K08722 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Pathway ko00760 http://www.genome.jp/kegg-bin/show_pathway?ko00760 KEGG_Reaction rn:R00183 http://www.genome.jp/dbget-bin/www_bget?rn:R00183 KEGG_Reaction rn:R00511 http://www.genome.jp/dbget-bin/www_bget?rn:R00511 KEGG_Reaction rn:R00963 http://www.genome.jp/dbget-bin/www_bget?rn:R00963 KEGG_Reaction rn:R01126 http://www.genome.jp/dbget-bin/www_bget?rn:R01126 KEGG_Reaction rn:R01227 http://www.genome.jp/dbget-bin/www_bget?rn:R01227 KEGG_Reaction rn:R01569 http://www.genome.jp/dbget-bin/www_bget?rn:R01569 KEGG_Reaction rn:R01664 http://www.genome.jp/dbget-bin/www_bget?rn:R01664 KEGG_Reaction rn:R01968 http://www.genome.jp/dbget-bin/www_bget?rn:R01968 KEGG_Reaction rn:R02088 http://www.genome.jp/dbget-bin/www_bget?rn:R02088 KEGG_Reaction rn:R02323 http://www.genome.jp/dbget-bin/www_bget?rn:R02323 KEGG_Reaction rn:R02719 http://www.genome.jp/dbget-bin/www_bget?rn:R02719 KEGG_Reaction rn:R03346 http://www.genome.jp/dbget-bin/www_bget?rn:R03346 OMA MPTPIKY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MPTPIKY PDB 2PAQ http://www.ebi.ac.uk/pdbe-srv/view/entry/2PAQ PDB 2PAR http://www.ebi.ac.uk/pdbe-srv/view/entry/2PAR PDB 2PAU http://www.ebi.ac.uk/pdbe-srv/view/entry/2PAU PDBsum 2PAQ http://www.ebi.ac.uk/pdbsum/2PAQ PDBsum 2PAR http://www.ebi.ac.uk/pdbsum/2PAR PDBsum 2PAU http://www.ebi.ac.uk/pdbsum/2PAU PSORT swissprot:5DNU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:5DNU_ECOLI PSORT-B swissprot:5DNU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:5DNU_ECOLI PSORT2 swissprot:5DNU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:5DNU_ECOLI Pfam PF13023 http://pfam.xfam.org/family/PF13023 Phobius swissprot:5DNU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:5DNU_ECOLI PhylomeDB P76491 http://phylomedb.org/?seqid=P76491 ProteinModelPortal P76491 http://www.proteinmodelportal.org/query/uniprot/P76491 PubMed 15489502 http://www.ncbi.nlm.nih.gov/pubmed/15489502 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17827303 http://www.ncbi.nlm.nih.gov/pubmed/17827303 PubMed 18353368 http://www.ncbi.nlm.nih.gov/pubmed/18353368 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416794 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416794 RefSeq WP_000813859 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000813859 SMART SM00471 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00471 SMR P76491 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76491 STRING 511145.b2291 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2291&targetmode=cogs STRING COG1896 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1896&targetmode=cogs UniProtKB 5DNU_ECOLI http://www.uniprot.org/uniprot/5DNU_ECOLI UniProtKB-AC P76491 http://www.uniprot.org/uniprot/P76491 charge swissprot:5DNU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:5DNU_ECOLI eggNOG COG1896 http://eggnogapi.embl.de/nog_data/html/tree/COG1896 eggNOG ENOG4105DK2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DK2 epestfind swissprot:5DNU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:5DNU_ECOLI garnier swissprot:5DNU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:5DNU_ECOLI helixturnhelix swissprot:5DNU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:5DNU_ECOLI hmoment swissprot:5DNU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:5DNU_ECOLI iep swissprot:5DNU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:5DNU_ECOLI inforesidue swissprot:5DNU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:5DNU_ECOLI octanol swissprot:5DNU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:5DNU_ECOLI pepcoil swissprot:5DNU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:5DNU_ECOLI pepdigest swissprot:5DNU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:5DNU_ECOLI pepinfo swissprot:5DNU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:5DNU_ECOLI pepnet swissprot:5DNU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:5DNU_ECOLI pepstats swissprot:5DNU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:5DNU_ECOLI pepwheel swissprot:5DNU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:5DNU_ECOLI pepwindow swissprot:5DNU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:5DNU_ECOLI sigcleave swissprot:5DNU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:5DNU_ECOLI ## Database ID URL or Descriptions # BioGrid 4260253 4 # EcoGene EG13191 ydgC # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR009707 GlpM/YdgC # Organism YDGC_ECOLI Escherichia coli (strain K12) # PATRIC 32118516 VBIEscCol129921_1678 # PIR A64917 A64917 # Pfam PF06942 GlpM # ProDom PD028709 GlpM # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDGC_ECOLI Inner membrane protein YdgC # RefSeq NP_416124 NC_000913.3 # RefSeq WP_000524868 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=U41101; Type=Frameshift; Positions=11, 38; Evidence={ECO 0000305}; # SIMILARITY To P.aeruginosa GlpM. {ECO 0000305}. # SUBCELLULAR LOCATION YDGC_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 9.B.72.1 the 4 tms glpm (glpm) family # eggNOG COG3136 LUCA # eggNOG ENOG4105RA2 Bacteria BLAST swissprot:YDGC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDGC_ECOLI BioCyc ECOL316407:JW1599-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1599-MONOMER BioCyc EcoCyc:G6863-MONOMER http://biocyc.org/getid?id=EcoCyc:G6863-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U41101 http://www.ebi.ac.uk/ena/data/view/U41101 EchoBASE EB2983 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2983 EcoGene EG13191 http://www.ecogene.org/geneInfo.php?eg_id=EG13191 EnsemblBacteria AAC74679 http://www.ensemblgenomes.org/id/AAC74679 EnsemblBacteria AAC74679 http://www.ensemblgenomes.org/id/AAC74679 EnsemblBacteria BAA15345 http://www.ensemblgenomes.org/id/BAA15345 EnsemblBacteria BAA15345 http://www.ensemblgenomes.org/id/BAA15345 EnsemblBacteria BAA15345 http://www.ensemblgenomes.org/id/BAA15345 EnsemblBacteria b1607 http://www.ensemblgenomes.org/id/b1607 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 945156 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945156 HOGENOM HOG000120863 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120863&db=HOGENOM6 InParanoid P0ACX0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACX0 IntAct P0ACX0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACX0* InterPro IPR009707 http://www.ebi.ac.uk/interpro/entry/IPR009707 KEGG_Gene ecj:JW1599 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1599 KEGG_Gene eco:b1607 http://www.genome.jp/dbget-bin/www_bget?eco:b1607 OMA YFVYLAT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YFVYLAT PSORT swissprot:YDGC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDGC_ECOLI PSORT-B swissprot:YDGC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDGC_ECOLI PSORT2 swissprot:YDGC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDGC_ECOLI Pfam PF06942 http://pfam.xfam.org/family/PF06942 Phobius swissprot:YDGC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDGC_ECOLI ProteinModelPortal P0ACX0 http://www.proteinmodelportal.org/query/uniprot/P0ACX0 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416124 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416124 RefSeq WP_000524868 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000524868 STRING 511145.b1607 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1607&targetmode=cogs TCDB 9.B.72.1 http://www.tcdb.org/search/result.php?tc=9.B.72.1 UniProtKB YDGC_ECOLI http://www.uniprot.org/uniprot/YDGC_ECOLI UniProtKB-AC P0ACX0 http://www.uniprot.org/uniprot/P0ACX0 charge swissprot:YDGC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDGC_ECOLI eggNOG COG3136 http://eggnogapi.embl.de/nog_data/html/tree/COG3136 eggNOG ENOG4105RA2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105RA2 epestfind swissprot:YDGC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDGC_ECOLI garnier swissprot:YDGC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDGC_ECOLI helixturnhelix swissprot:YDGC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDGC_ECOLI hmoment swissprot:YDGC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDGC_ECOLI iep swissprot:YDGC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDGC_ECOLI inforesidue swissprot:YDGC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDGC_ECOLI octanol swissprot:YDGC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDGC_ECOLI pepcoil swissprot:YDGC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDGC_ECOLI pepdigest swissprot:YDGC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDGC_ECOLI pepinfo swissprot:YDGC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDGC_ECOLI pepnet swissprot:YDGC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDGC_ECOLI pepstats swissprot:YDGC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDGC_ECOLI pepwheel swissprot:YDGC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDGC_ECOLI pepwindow swissprot:YDGC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDGC_ECOLI sigcleave swissprot:YDGC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDGC_ECOLI ## Database ID URL or Descriptions # BioGrid 4262798 6 # EcoGene EG13339 ykfA # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0003924 GTPase activity; IBA:GO_Central. # GO_function GO:0005525 GTP binding; IBA:GO_Central. # GO_function GO:0043022 ribosome binding; IBA:GO_Central. # GO_process GO:0000027 ribosomal large subunit assembly; IBA:GO_Central. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003924 GTPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0022618 ribonucleoprotein complex assembly # Gene3D 3.40.50.300 -; 2. # InterPro IPR006073 GTP_binding_domain # InterPro IPR027417 P-loop_NTPase # Organism YKFA_ECOLI Escherichia coli (strain K12) # PATRIC 32115625 VBIEscCol129921_0256 # PIR E64750 E64750 # Pfam PF01926 MMR_HSR1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YKFA_ECOLI Uncharacterized protein YkfA # RefSeq NP_414787 NC_000913.3 # RefSeq WP_001065553 NZ_LN832404.1 # SIMILARITY Contains 1 G (guanine nucleotide-binding) domain. {ECO 0000305}. # SIMILARITY To E.coli YfjP and YeeP. {ECO 0000305}. # SUPFAM SSF52540 SSF52540 # eggNOG COG3596 LUCA # eggNOG ENOG4108MXD Bacteria BLAST swissprot:YKFA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YKFA_ECOLI BioCyc ECOL316407:JW0243-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0243-MONOMER BioCyc EcoCyc:G6128-MONOMER http://biocyc.org/getid?id=EcoCyc:G6128-MONOMER COG COG3596 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3596 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EchoBASE EB3123 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3123 EcoGene EG13339 http://www.ecogene.org/geneInfo.php?eg_id=EG13339 EnsemblBacteria AAC73356 http://www.ensemblgenomes.org/id/AAC73356 EnsemblBacteria AAC73356 http://www.ensemblgenomes.org/id/AAC73356 EnsemblBacteria BAA77923 http://www.ensemblgenomes.org/id/BAA77923 EnsemblBacteria BAA77923 http://www.ensemblgenomes.org/id/BAA77923 EnsemblBacteria BAA77923 http://www.ensemblgenomes.org/id/BAA77923 EnsemblBacteria b0253 http://www.ensemblgenomes.org/id/b0253 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_function GO:0043022 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043022 GO_process GO:0000027 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000027 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0022618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022618 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 949004 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949004 HOGENOM HOG000121786 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000121786&db=HOGENOM6 InParanoid P75678 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75678 IntAct P75678 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75678* InterPro IPR006073 http://www.ebi.ac.uk/interpro/entry/IPR006073 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Gene ecj:JW0243 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0243 KEGG_Gene eco:b0253 http://www.genome.jp/dbget-bin/www_bget?eco:b0253 KEGG_Orthology KO:K06946 http://www.genome.jp/dbget-bin/www_bget?KO:K06946 OMA TERYSVC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TERYSVC PSORT swissprot:YKFA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YKFA_ECOLI PSORT-B swissprot:YKFA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YKFA_ECOLI PSORT2 swissprot:YKFA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YKFA_ECOLI Pfam PF01926 http://pfam.xfam.org/family/PF01926 Phobius swissprot:YKFA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YKFA_ECOLI PhylomeDB P75678 http://phylomedb.org/?seqid=P75678 ProteinModelPortal P75678 http://www.proteinmodelportal.org/query/uniprot/P75678 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414787 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414787 RefSeq WP_001065553 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001065553 SMR P75678 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75678 STRING 511145.b0253 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0253&targetmode=cogs STRING COG3596 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3596&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB YKFA_ECOLI http://www.uniprot.org/uniprot/YKFA_ECOLI UniProtKB-AC P75678 http://www.uniprot.org/uniprot/P75678 charge swissprot:YKFA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YKFA_ECOLI eggNOG COG3596 http://eggnogapi.embl.de/nog_data/html/tree/COG3596 eggNOG ENOG4108MXD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MXD epestfind swissprot:YKFA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YKFA_ECOLI garnier swissprot:YKFA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YKFA_ECOLI helixturnhelix swissprot:YKFA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YKFA_ECOLI hmoment swissprot:YKFA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YKFA_ECOLI iep swissprot:YKFA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YKFA_ECOLI inforesidue swissprot:YKFA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YKFA_ECOLI octanol swissprot:YKFA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YKFA_ECOLI pepcoil swissprot:YKFA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YKFA_ECOLI pepdigest swissprot:YKFA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YKFA_ECOLI pepinfo swissprot:YKFA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YKFA_ECOLI pepnet swissprot:YKFA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YKFA_ECOLI pepstats swissprot:YKFA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YKFA_ECOLI pepwheel swissprot:YKFA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YKFA_ECOLI pepwindow swissprot:YKFA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YKFA_ECOLI sigcleave swissprot:YKFA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YKFA_ECOLI ## Database ID URL or Descriptions # BioGrid 4263543 14 # EcoGene EG11388 fliS # GO_component GO:0005829 cytosol; IEA:UniProtKB-SubCell. # GO_process GO:0044780 bacterial-type flagellum assembly; IEA:InterPro. # GO_process GO:0071973 bacterial-type flagellum-dependent cell motility; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0048870 cell motility # Gene3D 1.20.120.340 -; 1. # IntAct P26608 19 # InterPro IPR003713 FliS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Pathway ko02040 Flagellar assembly # Organism FLIS_ECOLI Escherichia coli (strain K12) # PATRIC 32119185 VBIEscCol129921_2007 # PIR B64956 B64956 # PIRSF PIRSF039090 Flis # Pfam PF02561 FliS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FLIS_ECOLI Flagellar protein FliS # RefSeq NP_416435 NC_000913.3 # RefSeq WP_000270671 NZ_LN832404.1 # SIMILARITY Belongs to the FliS family. {ECO 0000305}. # SUBCELLULAR LOCATION FLIS_ECOLI Cytoplasm, cytosol {ECO 0000305}. # SUPFAM SSF101116 SSF101116 # TIGRFAMs TIGR00208 fliS # eggNOG COG1516 LUCA # eggNOG ENOG4105MQ3 Bacteria BLAST swissprot:FLIS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLIS_ECOLI BioCyc ECOL316407:JW1910-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1910-MONOMER BioCyc EcoCyc:EG11388-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11388-MONOMER COG COG1516 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1516 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1099/00221287-138-6-1051 http://dx.doi.org/10.1099/00221287-138-6-1051 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M85240 http://www.ebi.ac.uk/ena/data/view/M85240 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1361 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1361 EcoGene EG11388 http://www.ecogene.org/geneInfo.php?eg_id=EG11388 EnsemblBacteria AAC74992 http://www.ensemblgenomes.org/id/AAC74992 EnsemblBacteria AAC74992 http://www.ensemblgenomes.org/id/AAC74992 EnsemblBacteria BAA15753 http://www.ensemblgenomes.org/id/BAA15753 EnsemblBacteria BAA15753 http://www.ensemblgenomes.org/id/BAA15753 EnsemblBacteria BAA15753 http://www.ensemblgenomes.org/id/BAA15753 EnsemblBacteria b1925 http://www.ensemblgenomes.org/id/b1925 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_process GO:0044780 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044780 GO_process GO:0071973 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071973 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 Gene3D 1.20.120.340 http://www.cathdb.info/version/latest/superfamily/1.20.120.340 GeneID 946429 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946429 HOGENOM HOG000265826 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000265826&db=HOGENOM6 InParanoid P26608 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P26608 IntAct P26608 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P26608* InterPro IPR003713 http://www.ebi.ac.uk/interpro/entry/IPR003713 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW1910 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1910 KEGG_Gene eco:b1925 http://www.genome.jp/dbget-bin/www_bget?eco:b1925 KEGG_Orthology KO:K02422 http://www.genome.jp/dbget-bin/www_bget?KO:K02422 KEGG_Pathway ko02040 http://www.genome.jp/kegg-bin/show_pathway?ko02040 OMA AQSRYAI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AQSRYAI PSORT swissprot:FLIS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLIS_ECOLI PSORT-B swissprot:FLIS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLIS_ECOLI PSORT2 swissprot:FLIS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLIS_ECOLI Pfam PF02561 http://pfam.xfam.org/family/PF02561 Phobius swissprot:FLIS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLIS_ECOLI PhylomeDB P26608 http://phylomedb.org/?seqid=P26608 ProteinModelPortal P26608 http://www.proteinmodelportal.org/query/uniprot/P26608 PubMed 1527488 http://www.ncbi.nlm.nih.gov/pubmed/1527488 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416435 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416435 RefSeq WP_000270671 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000270671 SMR P26608 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P26608 STRING 511145.b1925 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1925&targetmode=cogs STRING COG1516 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1516&targetmode=cogs SUPFAM SSF101116 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF101116 TIGRFAMs TIGR00208 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00208 UniProtKB FLIS_ECOLI http://www.uniprot.org/uniprot/FLIS_ECOLI UniProtKB-AC P26608 http://www.uniprot.org/uniprot/P26608 charge swissprot:FLIS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLIS_ECOLI eggNOG COG1516 http://eggnogapi.embl.de/nog_data/html/tree/COG1516 eggNOG ENOG4105MQ3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105MQ3 epestfind swissprot:FLIS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLIS_ECOLI garnier swissprot:FLIS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLIS_ECOLI helixturnhelix swissprot:FLIS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLIS_ECOLI hmoment swissprot:FLIS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLIS_ECOLI iep swissprot:FLIS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLIS_ECOLI inforesidue swissprot:FLIS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLIS_ECOLI octanol swissprot:FLIS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLIS_ECOLI pepcoil swissprot:FLIS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLIS_ECOLI pepdigest swissprot:FLIS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLIS_ECOLI pepinfo swissprot:FLIS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLIS_ECOLI pepnet swissprot:FLIS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLIS_ECOLI pepstats swissprot:FLIS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLIS_ECOLI pepwheel swissprot:FLIS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLIS_ECOLI pepwindow swissprot:FLIS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLIS_ECOLI sigcleave swissprot:FLIS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLIS_ECOLI ## Database ID URL or Descriptions # BioGrid 4263302 14 # CDD cd10936 CE4_DAC2 # EcoGene EG12298 yibQ # GO_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; IEA:InterPro. # GO_process GO:0005975 carbohydrate metabolic process; IEA:InterPro. # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_process GO:0005975 carbohydrate metabolic process # Gene3D 3.20.20.370 -; 1. # InterPro IPR002509 NODB_dom # InterPro IPR006837 Divergent_DAC # InterPro IPR011330 Glyco_hydro/deAcase_b/a-brl # Organism YIBQ_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30105 PTHR30105 # PATRIC 32122715 VBIEscCol129921_3734 # PIR S47835 S47835 # Pfam PF04748 Polysacc_deac_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIBQ_ECOLI Uncharacterized protein YibQ # RefSeq NP_418071 NC_000913.3 # RefSeq WP_000483847 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18591.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY To H.influenzae HI_0755. {ECO 0000305}. # SUPFAM SSF88713 SSF88713 # eggNOG COG2861 LUCA # eggNOG ENOG4105PXI Bacteria BLAST swissprot:YIBQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIBQ_ECOLI BioCyc ECOL316407:JW5645-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5645-MONOMER BioCyc EcoCyc:EG12298-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12298-MONOMER COG COG2861 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2861 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2206 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2206 EcoGene EG12298 http://www.ecogene.org/geneInfo.php?eg_id=EG12298 EnsemblBacteria AAC76638 http://www.ensemblgenomes.org/id/AAC76638 EnsemblBacteria AAC76638 http://www.ensemblgenomes.org/id/AAC76638 EnsemblBacteria BAE77678 http://www.ensemblgenomes.org/id/BAE77678 EnsemblBacteria BAE77678 http://www.ensemblgenomes.org/id/BAE77678 EnsemblBacteria BAE77678 http://www.ensemblgenomes.org/id/BAE77678 EnsemblBacteria b3614 http://www.ensemblgenomes.org/id/b3614 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 Gene3D 3.20.20.370 http://www.cathdb.info/version/latest/superfamily/3.20.20.370 GeneID 948128 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948128 HOGENOM HOG000285219 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000285219&db=HOGENOM6 InParanoid P37691 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37691 InterPro IPR002509 http://www.ebi.ac.uk/interpro/entry/IPR002509 InterPro IPR006837 http://www.ebi.ac.uk/interpro/entry/IPR006837 InterPro IPR011330 http://www.ebi.ac.uk/interpro/entry/IPR011330 KEGG_Gene ecj:JW5645 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5645 KEGG_Gene eco:b3614 http://www.genome.jp/dbget-bin/www_bget?eco:b3614 KEGG_Orthology KO:K09798 http://www.genome.jp/dbget-bin/www_bget?KO:K09798 OMA YRPQTEN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YRPQTEN PANTHER PTHR30105 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30105 PSORT swissprot:YIBQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIBQ_ECOLI PSORT-B swissprot:YIBQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIBQ_ECOLI PSORT2 swissprot:YIBQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIBQ_ECOLI Pfam PF04748 http://pfam.xfam.org/family/PF04748 Phobius swissprot:YIBQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIBQ_ECOLI PhylomeDB P37691 http://phylomedb.org/?seqid=P37691 ProteinModelPortal P37691 http://www.proteinmodelportal.org/query/uniprot/P37691 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418071 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418071 RefSeq WP_000483847 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000483847 SMR P37691 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37691 STRING 511145.b3614 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3614&targetmode=cogs STRING COG2861 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2861&targetmode=cogs SUPFAM SSF88713 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF88713 UniProtKB YIBQ_ECOLI http://www.uniprot.org/uniprot/YIBQ_ECOLI UniProtKB-AC P37691 http://www.uniprot.org/uniprot/P37691 charge swissprot:YIBQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIBQ_ECOLI eggNOG COG2861 http://eggnogapi.embl.de/nog_data/html/tree/COG2861 eggNOG ENOG4105PXI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105PXI epestfind swissprot:YIBQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIBQ_ECOLI garnier swissprot:YIBQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIBQ_ECOLI helixturnhelix swissprot:YIBQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIBQ_ECOLI hmoment swissprot:YIBQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIBQ_ECOLI iep swissprot:YIBQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIBQ_ECOLI inforesidue swissprot:YIBQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIBQ_ECOLI octanol swissprot:YIBQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIBQ_ECOLI pepcoil swissprot:YIBQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIBQ_ECOLI pepdigest swissprot:YIBQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIBQ_ECOLI pepinfo swissprot:YIBQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIBQ_ECOLI pepnet swissprot:YIBQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIBQ_ECOLI pepstats swissprot:YIBQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIBQ_ECOLI pepwheel swissprot:YIBQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIBQ_ECOLI pepwindow swissprot:YIBQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIBQ_ECOLI sigcleave swissprot:YIBQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIBQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4261626 9 # EcoGene EG11928 yjbJ # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # Gene3D 1.10.1470.10 -; 1. # IntAct P68206 5 # InterPro IPR008462 CsbD # InterPro IPR026042 YjbJ # Organism YJBJ_ECOLI Escherichia coli (strain K12) # PATRIC 32123627 VBIEscCol129921_4162 # PDB 1RYK NMR; -; A=1-69 # PIR D65212 D65212 # PIRSF PIRSF039008 YjbJ # Pfam PF05532 CsbD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJBJ_ECOLI UPF0337 protein YjbJ # RefSeq NP_418469 NC_000913.3 # RefSeq WP_001030593 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0337 (CsbD) family. {ECO 0000305}. # SUPFAM SSF69047 SSF69047 # eggNOG COG3237 LUCA # eggNOG ENOG4105VDW Bacteria BLAST swissprot:YJBJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJBJ_ECOLI BioCyc ECOL316407:JW4005-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4005-MONOMER BioCyc EcoCyc:EG11928-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11928-MONOMER DIP DIP-48052N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48052N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1002/prot.10120.abs http://dx.doi.org/10.1002/prot.10120.abs DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1111/j.1574-6968.1998.tb13343.x http://dx.doi.org/10.1111/j.1574-6968.1998.tb13343.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1872 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1872 EcoGene EG11928 http://www.ecogene.org/geneInfo.php?eg_id=EG11928 EnsemblBacteria AAC77015 http://www.ensemblgenomes.org/id/AAC77015 EnsemblBacteria AAC77015 http://www.ensemblgenomes.org/id/AAC77015 EnsemblBacteria BAE78047 http://www.ensemblgenomes.org/id/BAE78047 EnsemblBacteria BAE78047 http://www.ensemblgenomes.org/id/BAE78047 EnsemblBacteria BAE78047 http://www.ensemblgenomes.org/id/BAE78047 EnsemblBacteria b4045 http://www.ensemblgenomes.org/id/b4045 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 Gene3D 1.10.1470.10 http://www.cathdb.info/version/latest/superfamily/1.10.1470.10 GeneID 948553 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948553 HOGENOM HOG000283480 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000283480&db=HOGENOM6 InParanoid P68206 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P68206 IntAct P68206 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P68206* InterPro IPR008462 http://www.ebi.ac.uk/interpro/entry/IPR008462 InterPro IPR026042 http://www.ebi.ac.uk/interpro/entry/IPR026042 KEGG_Gene ecj:JW4005 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4005 KEGG_Gene eco:b4045 http://www.genome.jp/dbget-bin/www_bget?eco:b4045 MINT MINT-1288760 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1288760 OMA NWDRIEG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NWDRIEG PDB 1RYK http://www.ebi.ac.uk/pdbe-srv/view/entry/1RYK PDBsum 1RYK http://www.ebi.ac.uk/pdbsum/1RYK PSORT swissprot:YJBJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJBJ_ECOLI PSORT-B swissprot:YJBJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJBJ_ECOLI PSORT2 swissprot:YJBJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJBJ_ECOLI Pfam PF05532 http://pfam.xfam.org/family/PF05532 Phobius swissprot:YJBJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJBJ_ECOLI PhylomeDB P68206 http://phylomedb.org/?seqid=P68206 ProteinModelPortal P68206 http://www.proteinmodelportal.org/query/uniprot/P68206 PubMed 12001238 http://www.ncbi.nlm.nih.gov/pubmed/12001238 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9868784 http://www.ncbi.nlm.nih.gov/pubmed/9868784 RefSeq NP_418469 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418469 RefSeq WP_001030593 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001030593 SMR P68206 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P68206 STRING 511145.b4045 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4045&targetmode=cogs SUPFAM SSF69047 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF69047 UniProtKB YJBJ_ECOLI http://www.uniprot.org/uniprot/YJBJ_ECOLI UniProtKB-AC P68206 http://www.uniprot.org/uniprot/P68206 charge swissprot:YJBJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJBJ_ECOLI eggNOG COG3237 http://eggnogapi.embl.de/nog_data/html/tree/COG3237 eggNOG ENOG4105VDW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VDW epestfind swissprot:YJBJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJBJ_ECOLI garnier swissprot:YJBJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJBJ_ECOLI helixturnhelix swissprot:YJBJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJBJ_ECOLI hmoment swissprot:YJBJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJBJ_ECOLI iep swissprot:YJBJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJBJ_ECOLI inforesidue swissprot:YJBJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJBJ_ECOLI octanol swissprot:YJBJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJBJ_ECOLI pepcoil swissprot:YJBJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJBJ_ECOLI pepdigest swissprot:YJBJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJBJ_ECOLI pepinfo swissprot:YJBJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJBJ_ECOLI pepnet swissprot:YJBJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJBJ_ECOLI pepstats swissprot:YJBJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJBJ_ECOLI pepwheel swissprot:YJBJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJBJ_ECOLI pepwindow swissprot:YJBJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJBJ_ECOLI sigcleave swissprot:YJBJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJBJ_ECOLI ## Database ID URL or Descriptions # AltName RNA polymerase subunit beta' {ECO:0000255|HAMAP-Rule MF_01322} # AltName Transcriptase subunit beta' {ECO:0000255|HAMAP-Rule MF_01322} # BioGrid 4262959 22 # CATALYTIC ACTIVITY Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). {ECO:0000255|HAMAP-Rule MF_01322}. # DrugBank DB00615 Rifabutin # DrugBank DB01045 Rifampicin # EcoGene EG10895 rpoC # FUNCTION RPOC_ECOLI DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. {ECO 0000255|HAMAP-Rule MF_01322, ECO 0000269|PubMed 1646077}. # GO_component GO:0000428 DNA-directed RNA polymerase complex; IBA:GO_Central. # GO_component GO:0005737 cytoplasm; IDA:UniProtKB. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0003899 DNA-directed RNA polymerase activity; IEA:UniProtKB-HAMAP. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # HAMAP MF_01322 RNApol_bact_RpoC # INTERACTION RPOC_ECOLI P0A6Z3 htpG; NbExp=2; IntAct=EBI-543604, EBI-369221; P0A8V2 rpoB; NbExp=7; IntAct=EBI-543604, EBI-544996; P00579 rpoD; NbExp=8; IntAct=EBI-543604, EBI-545104; # IntAct P0A8T7 113 # InterPro IPR000722 RNA_pol_asu # InterPro IPR006592 RNA_pol_N # InterPro IPR007066 RNA_pol_Rpb1_3 # InterPro IPR007080 RNA_pol_Rpb1_1 # InterPro IPR007081 RNA_pol_Rpb1_5 # InterPro IPR007083 RNA_pol_Rpb1_4 # InterPro IPR012754 DNA-dir_RpoC_beta_prime # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03021 M00183 RNA polymerase, bacteria # KEGG_Brite ko03021 Transcription machinery # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Brite ko03400 M00183 RNA polymerase, bacteria # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00240 Pyrimidine metabolism # KEGG_Pathway ko03020 RNA polymerase # Organism RPOC_ECOLI Escherichia coli (strain K12) # PATRIC 32123497 VBIEscCol129921_4101 # PDB 2AUK X-ray; 2.30 A; A/B/C/D/E=944-1129 # PDB 2LMC NMR; -; B=1151-1213 # PDB 3IYD EM; -; D=1-1407 # PDB 3LU0 EM; -; D=1-1407 # PDB 4IQZ X-ray; 2.10 A; A/B/C/D/E=932-1141 # PDB 4JK1 X-ray; 3.90 A; D/I=1-1407 # PDB 4JK2 X-ray; 4.20 A; D/I=1-1407 # PDB 4KMU X-ray; 3.85 A; D/I=1-1407 # PDB 4KN4 X-ray; 3.96 A; D/I=1-1407 # PDB 4KN7 X-ray; 3.69 A; D/I=1-1407 # PDB 4MEX X-ray; 3.90 A; D/J=1-1407 # PDB 4MEY X-ray; 3.95 A; D/J=1-1407 # PDB 4XSX X-ray; 3.71 A; D/J=1-1407 # PDB 4XSY X-ray; 4.01 A; D/J=1-1407 # PDB 4XSZ X-ray; 3.68 A; D/J=1-1407 # PDB 4YG2 X-ray; 3.70 A; D/J=1-1407 # PDB 4YLN X-ray; 5.50 A; D/J/P=1-1407 # PDB 4YLO X-ray; 6.00 A; D/J/P=1-1407 # PDB 4YLP X-ray; 5.50 A; D/J/P=1-1407 # PDB 4ZH2 X-ray; 4.20 A; D/J=1-1407 # PDB 4ZH3 X-ray; 4.08 A; D/J=1-1407 # PDB 4ZH4 X-ray; 3.99 A; D/J=1-1407 # PDB 5BYH X-ray; 3.76 A; D=1-1407 # PDB 5EZK X-ray; 8.50 A; D=1-1407 # PDB 5IPL X-ray; 3.60 A; D=1-1407 # PDB 5IPM X-ray; 4.20 A; D=1-1407 # PDB 5IPN X-ray; 4.61 A; D=1-1407 # PIR A00695 RNECC # PTM RPOC_ECOLI Acetylated on several lysine residues in the presence of glucose. {ECO 0000269|PubMed 18723842, ECO 0000269|PubMed 21696463}. # Pfam PF00623 RNA_pol_Rpb1_2; 2 # Pfam PF04983 RNA_pol_Rpb1_3 # Pfam PF04997 RNA_pol_Rpb1_1 # Pfam PF04998 RNA_pol_Rpb1_5 # Pfam PF05000 RNA_pol_Rpb1_4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DNA-directed RNA polymerase subunit beta' {ECO:0000255|HAMAP-Rule MF_01322} # RefSeq NP_418415 NC_000913.3 # RefSeq WP_000653944 NZ_LN832404.1 # SIMILARITY Belongs to the RNA polymerase beta' chain family. {ECO:0000255|HAMAP-Rule MF_01322}. # SMART SM00663 RPOLA_N # SUBUNIT The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. {ECO:0000255|HAMAP-Rule MF_01322}. # TIGRFAMs TIGR02386 rpoC_TIGR # eggNOG COG0086 LUCA # eggNOG ENOG4105D27 Bacteria BLAST swissprot:RPOC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RPOC_ECOLI BioCyc ECOL316407:JW3951-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3951-MONOMER BioCyc EcoCyc:RPOC-MONOMER http://biocyc.org/getid?id=EcoCyc:RPOC-MONOMER BioCyc MetaCyc:RPOC-MONOMER http://biocyc.org/getid?id=MetaCyc:RPOC-MONOMER COG COG0086 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0086 DIP DIP-35803N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35803N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0014-5793(75)81001-5 http://dx.doi.org/10.1016/0014-5793(75)81001-5 DOI 10.1016/0092-8674(91)90553-B http://dx.doi.org/10.1016/0092-8674(91)90553-B DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0908782106 http://dx.doi.org/10.1073/pnas.0908782106 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/nar/10.13.4035 http://dx.doi.org/10.1093/nar/10.13.4035 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1093/nar/9.24.6827 http://dx.doi.org/10.1093/nar/9.24.6827 DOI 10.1111/j.1365-2958.2011.07742.x http://dx.doi.org/10.1111/j.1365-2958.2011.07742.x DOI 10.1111/j.1432-1033.1981.tb05381.x http://dx.doi.org/10.1111/j.1432-1033.1981.tb05381.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB00615 http://www.drugbank.ca/drugs/DB00615 DrugBank DB01045 http://www.drugbank.ca/drugs/DB01045 EC_number EC:2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01322} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01322} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M38288 http://www.ebi.ac.uk/ena/data/view/M38288 EMBL M38293 http://www.ebi.ac.uk/ena/data/view/M38293 EMBL M38303 http://www.ebi.ac.uk/ena/data/view/M38303 EMBL M38305 http://www.ebi.ac.uk/ena/data/view/M38305 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00339 http://www.ebi.ac.uk/ena/data/view/V00339 EMBL V00340 http://www.ebi.ac.uk/ena/data/view/V00340 ENZYME 2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01322} http://enzyme.expasy.org/EC/2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01322} EchoBASE EB0888 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0888 EcoGene EG10895 http://www.ecogene.org/geneInfo.php?eg_id=EG10895 EnsemblBacteria AAC76962 http://www.ensemblgenomes.org/id/AAC76962 EnsemblBacteria AAC76962 http://www.ensemblgenomes.org/id/AAC76962 EnsemblBacteria BAE77332 http://www.ensemblgenomes.org/id/BAE77332 EnsemblBacteria BAE77332 http://www.ensemblgenomes.org/id/BAE77332 EnsemblBacteria BAE77332 http://www.ensemblgenomes.org/id/BAE77332 EnsemblBacteria b3988 http://www.ensemblgenomes.org/id/b3988 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0000428 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000428 GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003899 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003899 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 948487 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948487 HAMAP MF_01322 http://hamap.expasy.org/unirule/MF_01322 HOGENOM HOG000218386 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218386&db=HOGENOM6 InParanoid P0A8T7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8T7 IntAct P0A8T7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8T7* IntEnz 2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01322} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.6 {ECO:0000255|HAMAP-Rule:MF_01322} InterPro IPR000722 http://www.ebi.ac.uk/interpro/entry/IPR000722 InterPro IPR006592 http://www.ebi.ac.uk/interpro/entry/IPR006592 InterPro IPR007066 http://www.ebi.ac.uk/interpro/entry/IPR007066 InterPro IPR007080 http://www.ebi.ac.uk/interpro/entry/IPR007080 InterPro IPR007081 http://www.ebi.ac.uk/interpro/entry/IPR007081 InterPro IPR007083 http://www.ebi.ac.uk/interpro/entry/IPR007083 InterPro IPR012754 http://www.ebi.ac.uk/interpro/entry/IPR012754 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03021 http://www.genome.jp/dbget-bin/www_bget?ko03021 KEGG_Brite ko03021 http://www.genome.jp/dbget-bin/www_bget?ko03021 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW3951 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3951 KEGG_Gene eco:b3988 http://www.genome.jp/dbget-bin/www_bget?eco:b3988 KEGG_Orthology KO:K03046 http://www.genome.jp/dbget-bin/www_bget?KO:K03046 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Pathway ko03020 http://www.genome.jp/kegg-bin/show_pathway?ko03020 KEGG_Reaction rn:R00435 http://www.genome.jp/dbget-bin/www_bget?rn:R00435 KEGG_Reaction rn:R00441 http://www.genome.jp/dbget-bin/www_bget?rn:R00441 KEGG_Reaction rn:R00442 http://www.genome.jp/dbget-bin/www_bget?rn:R00442 KEGG_Reaction rn:R00443 http://www.genome.jp/dbget-bin/www_bget?rn:R00443 MINT MINT-1220667 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1220667 OMA YDLVNQN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YDLVNQN PDB 2AUK http://www.ebi.ac.uk/pdbe-srv/view/entry/2AUK PDB 2LMC http://www.ebi.ac.uk/pdbe-srv/view/entry/2LMC PDB 3IYD http://www.ebi.ac.uk/pdbe-srv/view/entry/3IYD PDB 3LU0 http://www.ebi.ac.uk/pdbe-srv/view/entry/3LU0 PDB 4IQZ http://www.ebi.ac.uk/pdbe-srv/view/entry/4IQZ PDB 4JK1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4JK1 PDB 4JK2 http://www.ebi.ac.uk/pdbe-srv/view/entry/4JK2 PDB 4KMU http://www.ebi.ac.uk/pdbe-srv/view/entry/4KMU PDB 4KN4 http://www.ebi.ac.uk/pdbe-srv/view/entry/4KN4 PDB 4KN7 http://www.ebi.ac.uk/pdbe-srv/view/entry/4KN7 PDB 4MEX http://www.ebi.ac.uk/pdbe-srv/view/entry/4MEX PDB 4MEY http://www.ebi.ac.uk/pdbe-srv/view/entry/4MEY PDB 4XSX http://www.ebi.ac.uk/pdbe-srv/view/entry/4XSX PDB 4XSY http://www.ebi.ac.uk/pdbe-srv/view/entry/4XSY PDB 4XSZ http://www.ebi.ac.uk/pdbe-srv/view/entry/4XSZ PDB 4YG2 http://www.ebi.ac.uk/pdbe-srv/view/entry/4YG2 PDB 4YLN http://www.ebi.ac.uk/pdbe-srv/view/entry/4YLN PDB 4YLO http://www.ebi.ac.uk/pdbe-srv/view/entry/4YLO PDB 4YLP http://www.ebi.ac.uk/pdbe-srv/view/entry/4YLP PDB 4ZH2 http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZH2 PDB 4ZH3 http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZH3 PDB 4ZH4 http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZH4 PDB 5BYH http://www.ebi.ac.uk/pdbe-srv/view/entry/5BYH PDB 5EZK http://www.ebi.ac.uk/pdbe-srv/view/entry/5EZK PDB 5IPL http://www.ebi.ac.uk/pdbe-srv/view/entry/5IPL PDB 5IPM http://www.ebi.ac.uk/pdbe-srv/view/entry/5IPM PDB 5IPN http://www.ebi.ac.uk/pdbe-srv/view/entry/5IPN PDBsum 2AUK http://www.ebi.ac.uk/pdbsum/2AUK PDBsum 2LMC http://www.ebi.ac.uk/pdbsum/2LMC PDBsum 3IYD http://www.ebi.ac.uk/pdbsum/3IYD PDBsum 3LU0 http://www.ebi.ac.uk/pdbsum/3LU0 PDBsum 4IQZ http://www.ebi.ac.uk/pdbsum/4IQZ PDBsum 4JK1 http://www.ebi.ac.uk/pdbsum/4JK1 PDBsum 4JK2 http://www.ebi.ac.uk/pdbsum/4JK2 PDBsum 4KMU http://www.ebi.ac.uk/pdbsum/4KMU PDBsum 4KN4 http://www.ebi.ac.uk/pdbsum/4KN4 PDBsum 4KN7 http://www.ebi.ac.uk/pdbsum/4KN7 PDBsum 4MEX http://www.ebi.ac.uk/pdbsum/4MEX PDBsum 4MEY http://www.ebi.ac.uk/pdbsum/4MEY PDBsum 4XSX http://www.ebi.ac.uk/pdbsum/4XSX PDBsum 4XSY http://www.ebi.ac.uk/pdbsum/4XSY PDBsum 4XSZ http://www.ebi.ac.uk/pdbsum/4XSZ PDBsum 4YG2 http://www.ebi.ac.uk/pdbsum/4YG2 PDBsum 4YLN http://www.ebi.ac.uk/pdbsum/4YLN PDBsum 4YLO http://www.ebi.ac.uk/pdbsum/4YLO PDBsum 4YLP http://www.ebi.ac.uk/pdbsum/4YLP PDBsum 4ZH2 http://www.ebi.ac.uk/pdbsum/4ZH2 PDBsum 4ZH3 http://www.ebi.ac.uk/pdbsum/4ZH3 PDBsum 4ZH4 http://www.ebi.ac.uk/pdbsum/4ZH4 PDBsum 5BYH http://www.ebi.ac.uk/pdbsum/5BYH PDBsum 5EZK http://www.ebi.ac.uk/pdbsum/5EZK PDBsum 5IPL http://www.ebi.ac.uk/pdbsum/5IPL PDBsum 5IPM http://www.ebi.ac.uk/pdbsum/5IPM PDBsum 5IPN http://www.ebi.ac.uk/pdbsum/5IPN PSORT swissprot:RPOC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RPOC_ECOLI PSORT-B swissprot:RPOC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RPOC_ECOLI PSORT2 swissprot:RPOC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RPOC_ECOLI Pfam PF00623 http://pfam.xfam.org/family/PF00623 Pfam PF04983 http://pfam.xfam.org/family/PF04983 Pfam PF04997 http://pfam.xfam.org/family/PF04997 Pfam PF04998 http://pfam.xfam.org/family/PF04998 Pfam PF05000 http://pfam.xfam.org/family/PF05000 Phobius swissprot:RPOC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RPOC_ECOLI PhylomeDB P0A8T7 http://phylomedb.org/?seqid=P0A8T7 ProteinModelPortal P0A8T7 http://www.proteinmodelportal.org/query/uniprot/P0A8T7 PubMed 1095419 http://www.ncbi.nlm.nih.gov/pubmed/1095419 PubMed 1646077 http://www.ncbi.nlm.nih.gov/pubmed/1646077 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 19903881 http://www.ncbi.nlm.nih.gov/pubmed/19903881 PubMed 21696463 http://www.ncbi.nlm.nih.gov/pubmed/21696463 PubMed 6266829 http://www.ncbi.nlm.nih.gov/pubmed/6266829 PubMed 6278450 http://www.ncbi.nlm.nih.gov/pubmed/6278450 PubMed 6287430 http://www.ncbi.nlm.nih.gov/pubmed/6287430 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_418415 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418415 RefSeq WP_000653944 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000653944 SMART SM00663 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00663 SMR P0A8T7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8T7 STRING 511145.b3988 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3988&targetmode=cogs STRING COG0086 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0086&targetmode=cogs TIGRFAMs TIGR02386 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02386 UniProtKB RPOC_ECOLI http://www.uniprot.org/uniprot/RPOC_ECOLI UniProtKB-AC P0A8T7 http://www.uniprot.org/uniprot/P0A8T7 charge swissprot:RPOC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RPOC_ECOLI eggNOG COG0086 http://eggnogapi.embl.de/nog_data/html/tree/COG0086 eggNOG ENOG4105D27 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D27 epestfind swissprot:RPOC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RPOC_ECOLI garnier swissprot:RPOC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RPOC_ECOLI helixturnhelix swissprot:RPOC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RPOC_ECOLI hmoment swissprot:RPOC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RPOC_ECOLI iep swissprot:RPOC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RPOC_ECOLI inforesidue swissprot:RPOC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RPOC_ECOLI octanol swissprot:RPOC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RPOC_ECOLI pepcoil swissprot:RPOC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RPOC_ECOLI pepdigest swissprot:RPOC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RPOC_ECOLI pepinfo swissprot:RPOC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RPOC_ECOLI pepnet swissprot:RPOC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RPOC_ECOLI pepstats swissprot:RPOC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RPOC_ECOLI pepwheel swissprot:RPOC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RPOC_ECOLI pepwindow swissprot:RPOC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RPOC_ECOLI sigcleave swissprot:RPOC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RPOC_ECOLI ## Database ID URL or Descriptions # AltName TRMB_ECOLI tRNA(m7G46)-methyltransferase {ECO 0000255|HAMAP-Rule MF_01057, ECO 0000303|PubMed 12730187} # AltName tRNA (guanine(46)-N(7))-methyltransferase {ECO:0000255|HAMAP-Rule MF_01057} # BRENDA 2.1.1.33 2026 # BioGrid 4262358 9 # CATALYTIC ACTIVITY TRMB_ECOLI S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA. {ECO 0000255|HAMAP-Rule MF_01057, ECO 0000269|PubMed 12730187}. # EcoGene EG11779 trmI # FUNCTION TRMB_ECOLI Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. {ECO 0000255|HAMAP-Rule MF_01057, ECO 0000269|PubMed 12730187}. # GO_component GO:0043527 tRNA methyltransferase complex; IBA:GO_Central. # GO_function GO:0008176 tRNA (guanine-N7-)-methyltransferase activity; IDA:EcoCyc. # GO_process GO:0030488 tRNA methylation; IMP:EcoCyc. # GO_process GO:0036265 RNA (guanine-N7)-methylation; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.50.150 -; 1. # HAMAP MF_01057 tRNA_methyltr_TrmB # IntAct P0A8I5 45 # InterPro IPR003358 tRNA_(Gua-N-7)_MeTrfase_Trmb # InterPro IPR029063 SAM-dependent_MTases # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # Organism TRMB_ECOLI Escherichia coli (strain K12) # PATHWAY TRMB_ECOLI tRNA modification; N(7)-methylguanine-tRNA biosynthesis. {ECO 0000255|HAMAP-Rule MF_01057, ECO 0000305|PubMed 12730187}. # PATRIC 32121334 VBIEscCol129921_3055 # PDB 3DXX X-ray; 2.05 A; A=33-239 # PDB 3DXY X-ray; 1.50 A; A=33-239 # PDB 3DXZ X-ray; 1.58 A; A=33-239 # PIR G65081 G65081 # PROSITE PS51625 SAM_MT_TRMB # Pfam PF02390 Methyltransf_4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName tRNA (guanine-N(7)-)-methyltransferase {ECO:0000255|HAMAP-Rule MF_01057} # RefSeq NP_417435 NC_000913.3 # RefSeq WP_000786911 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA72956.1; Type=Frameshift; Positions=29; Evidence={ECO 0000305}; # SIMILARITY Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family. {ECO:0000255|HAMAP- Rule MF_01057, ECO:0000305}. # SUBUNIT TRMB_ECOLI Monomer. {ECO 0000255|HAMAP-Rule MF_01057, ECO 0000269|PubMed 12730187}. # SUPFAM SSF53335 SSF53335 # TIGRFAMs TIGR00091 TIGR00091 # eggNOG COG0220 LUCA # eggNOG ENOG4105CZ1 Bacteria BLAST swissprot:TRMB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRMB_ECOLI BioCyc ECOL316407:JW2927-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2927-MONOMER BioCyc EcoCyc:EG11779-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11779-MONOMER BioCyc MetaCyc:EG11779-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11779-MONOMER COG COG0220 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0220 DIP DIP-36015N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36015N DOI 10.1002/prot.20454 http://dx.doi.org/10.1002/prot.20454 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.185.10.3238-3243.2003 http://dx.doi.org/10.1128/JB.185.10.3238-3243.2003 EC_number EC:2.1.1.33 {ECO:0000255|HAMAP-Rule:MF_01057, ECO:0000269|PubMed:12730187} http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.33 {ECO:0000255|HAMAP-Rule:MF_01057, ECO:0000269|PubMed:12730187} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M59471 http://www.ebi.ac.uk/ena/data/view/M59471 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 ENZYME 2.1.1.33 {ECO:0000255|HAMAP-Rule:MF_01057, ECO:0000269|PubMed:12730187} http://enzyme.expasy.org/EC/2.1.1.33 {ECO:0000255|HAMAP-Rule:MF_01057, ECO:0000269|PubMed:12730187} EchoBASE EB1727 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1727 EcoGene EG11779 http://www.ecogene.org/geneInfo.php?eg_id=EG11779 EnsemblBacteria AAC75997 http://www.ensemblgenomes.org/id/AAC75997 EnsemblBacteria AAC75997 http://www.ensemblgenomes.org/id/AAC75997 EnsemblBacteria BAE77023 http://www.ensemblgenomes.org/id/BAE77023 EnsemblBacteria BAE77023 http://www.ensemblgenomes.org/id/BAE77023 EnsemblBacteria BAE77023 http://www.ensemblgenomes.org/id/BAE77023 EnsemblBacteria b2960 http://www.ensemblgenomes.org/id/b2960 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0043527 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043527 GO_function GO:0008176 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008176 GO_process GO:0030488 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030488 GO_process GO:0036265 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036265 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 GeneID 947448 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947448 HAMAP MF_01057 http://hamap.expasy.org/unirule/MF_01057 HOGENOM HOG000073968 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000073968&db=HOGENOM6 InParanoid P0A8I5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8I5 IntAct P0A8I5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8I5* IntEnz 2.1.1.33 {ECO:0000255|HAMAP-Rule:MF_01057, ECO:0000269|PubMed:12730187} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.33 {ECO:0000255|HAMAP-Rule:MF_01057, ECO:0000269|PubMed:12730187} InterPro IPR003358 http://www.ebi.ac.uk/interpro/entry/IPR003358 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW2927 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2927 KEGG_Gene eco:b2960 http://www.genome.jp/dbget-bin/www_bget?eco:b2960 KEGG_Orthology KO:K03439 http://www.genome.jp/dbget-bin/www_bget?KO:K03439 OMA GNLRVMC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GNLRVMC PDB 3DXX http://www.ebi.ac.uk/pdbe-srv/view/entry/3DXX PDB 3DXY http://www.ebi.ac.uk/pdbe-srv/view/entry/3DXY PDB 3DXZ http://www.ebi.ac.uk/pdbe-srv/view/entry/3DXZ PDBsum 3DXX http://www.ebi.ac.uk/pdbsum/3DXX PDBsum 3DXY http://www.ebi.ac.uk/pdbsum/3DXY PDBsum 3DXZ http://www.ebi.ac.uk/pdbsum/3DXZ PROSITE PS51625 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51625 PSORT swissprot:TRMB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRMB_ECOLI PSORT-B swissprot:TRMB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRMB_ECOLI PSORT2 swissprot:TRMB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRMB_ECOLI Pfam PF02390 http://pfam.xfam.org/family/PF02390 Phobius swissprot:TRMB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRMB_ECOLI PhylomeDB P0A8I5 http://phylomedb.org/?seqid=P0A8I5 ProteinModelPortal P0A8I5 http://www.proteinmodelportal.org/query/uniprot/P0A8I5 PubMed 12730187 http://www.ncbi.nlm.nih.gov/pubmed/12730187 PubMed 15789416 http://www.ncbi.nlm.nih.gov/pubmed/15789416 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2001994 http://www.ncbi.nlm.nih.gov/pubmed/2001994 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417435 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417435 RefSeq WP_000786911 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000786911 SMR P0A8I5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8I5 STRING 511145.b2960 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2960&targetmode=cogs STRING COG0220 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0220&targetmode=cogs SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 TIGRFAMs TIGR00091 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00091 UniProtKB TRMB_ECOLI http://www.uniprot.org/uniprot/TRMB_ECOLI UniProtKB-AC P0A8I5 http://www.uniprot.org/uniprot/P0A8I5 charge swissprot:TRMB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRMB_ECOLI eggNOG COG0220 http://eggnogapi.embl.de/nog_data/html/tree/COG0220 eggNOG ENOG4105CZ1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CZ1 epestfind swissprot:TRMB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRMB_ECOLI garnier swissprot:TRMB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRMB_ECOLI helixturnhelix swissprot:TRMB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRMB_ECOLI hmoment swissprot:TRMB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRMB_ECOLI iep swissprot:TRMB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRMB_ECOLI inforesidue swissprot:TRMB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRMB_ECOLI octanol swissprot:TRMB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRMB_ECOLI pepcoil swissprot:TRMB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRMB_ECOLI pepdigest swissprot:TRMB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRMB_ECOLI pepinfo swissprot:TRMB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRMB_ECOLI pepnet swissprot:TRMB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRMB_ECOLI pepstats swissprot:TRMB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRMB_ECOLI pepwheel swissprot:TRMB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRMB_ECOLI pepwindow swissprot:TRMB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRMB_ECOLI sigcleave swissprot:TRMB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRMB_ECOLI ## Database ID URL or Descriptions # AltName NANE_ECOLI ManNAc-6-P epimerase # BioGrid 4261228 113 # CATALYTIC ACTIVITY NANE_ECOLI N-acyl-D-glucosamine 6-phosphate = N-acyl-D- mannosamine 6-phosphate. # CDD cd04729 NanE # EcoGene EG12816 nanE # FUNCTION NANE_ECOLI Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P). {ECO 0000305}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0047465 N-acylglucosamine-6-phosphate 2-epimerase activity; NAS:EcoCyc. # GO_process GO:0005975 carbohydrate metabolic process; IEA:UniProtKB-HAMAP. # GO_process GO:0006053 N-acetylmannosamine catabolic process; IMP:EcoCyc. # GO_process GO:0019262 N-acetylneuraminate catabolic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.70 -; 1. # HAMAP MF_01235 ManNAc6P_epimer # IntAct P0A761 8 # InterPro IPR007260 NanE # InterPro IPR011060 RibuloseP-bd_barrel # InterPro IPR013785 Aldolase_TIM # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00520 Amino sugar and nucleotide sugar metabolism # Organism NANE_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate step 3/5. # PATRIC 32121870 VBIEscCol129921_3319 # PIR A65114 A65114 # Pfam PF04131 NanE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NANE_ECOLI Putative N-acetylmannosamine-6-phosphate 2-epimerase # RefSeq NP_417690 NC_000913.3 # RefSeq WP_000054239 NZ_LN832404.1 # SIMILARITY Belongs to the NanE family. {ECO 0000305}. # SUPFAM SSF51366 SSF51366 # UniPathway UPA00629 UER00682 # eggNOG COG3010 LUCA # eggNOG ENOG4105C9S Bacteria BLAST swissprot:NANE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NANE_ECOLI BioCyc ECOL316407:JW3192-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3192-MONOMER BioCyc EcoCyc:NANE-MONOMER http://biocyc.org/getid?id=EcoCyc:NANE-MONOMER COG COG3010 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3010 DIP DIP-48021N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48021N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.1.3.9 http://www.genome.jp/dbget-bin/www_bget?EC:5.1.3.9 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 5.1.3.9 http://enzyme.expasy.org/EC/5.1.3.9 EchoBASE EB2667 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2667 EcoGene EG12816 http://www.ecogene.org/geneInfo.php?eg_id=EG12816 EnsemblBacteria AAC76255 http://www.ensemblgenomes.org/id/AAC76255 EnsemblBacteria AAC76255 http://www.ensemblgenomes.org/id/AAC76255 EnsemblBacteria BAE77266 http://www.ensemblgenomes.org/id/BAE77266 EnsemblBacteria BAE77266 http://www.ensemblgenomes.org/id/BAE77266 EnsemblBacteria BAE77266 http://www.ensemblgenomes.org/id/BAE77266 EnsemblBacteria b3223 http://www.ensemblgenomes.org/id/b3223 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0047465 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047465 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GO_process GO:0006053 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006053 GO_process GO:0019262 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019262 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 947745 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947745 HAMAP MF_01235 http://hamap.expasy.org/unirule/MF_01235 HOGENOM HOG000236669 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000236669&db=HOGENOM6 InParanoid P0A761 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A761 IntAct P0A761 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A761* IntEnz 5.1.3.9 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.1.3.9 InterPro IPR007260 http://www.ebi.ac.uk/interpro/entry/IPR007260 InterPro IPR011060 http://www.ebi.ac.uk/interpro/entry/IPR011060 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3192 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3192 KEGG_Gene eco:b3223 http://www.genome.jp/dbget-bin/www_bget?eco:b3223 KEGG_Orthology KO:K01788 http://www.genome.jp/dbget-bin/www_bget?KO:K01788 KEGG_Pathway ko00520 http://www.genome.jp/kegg-bin/show_pathway?ko00520 KEGG_Reaction rn:R02087 http://www.genome.jp/dbget-bin/www_bget?rn:R02087 MINT MINT-1307633 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1307633 OMA ITRPMEI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ITRPMEI PSORT swissprot:NANE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NANE_ECOLI PSORT-B swissprot:NANE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NANE_ECOLI PSORT2 swissprot:NANE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NANE_ECOLI Pfam PF04131 http://pfam.xfam.org/family/PF04131 Phobius swissprot:NANE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NANE_ECOLI PhylomeDB P0A761 http://phylomedb.org/?seqid=P0A761 ProteinModelPortal P0A761 http://www.proteinmodelportal.org/query/uniprot/P0A761 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9864311 http://www.ncbi.nlm.nih.gov/pubmed/9864311 RefSeq NP_417690 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417690 RefSeq WP_000054239 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000054239 SMR P0A761 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A761 STRING 511145.b3223 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3223&targetmode=cogs STRING COG3010 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3010&targetmode=cogs SUPFAM SSF51366 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51366 UniProtKB NANE_ECOLI http://www.uniprot.org/uniprot/NANE_ECOLI UniProtKB-AC P0A761 http://www.uniprot.org/uniprot/P0A761 charge swissprot:NANE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NANE_ECOLI eggNOG COG3010 http://eggnogapi.embl.de/nog_data/html/tree/COG3010 eggNOG ENOG4105C9S http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C9S epestfind swissprot:NANE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NANE_ECOLI garnier swissprot:NANE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NANE_ECOLI helixturnhelix swissprot:NANE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NANE_ECOLI hmoment swissprot:NANE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NANE_ECOLI iep swissprot:NANE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NANE_ECOLI inforesidue swissprot:NANE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NANE_ECOLI octanol swissprot:NANE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NANE_ECOLI pepcoil swissprot:NANE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NANE_ECOLI pepdigest swissprot:NANE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NANE_ECOLI pepinfo swissprot:NANE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NANE_ECOLI pepnet swissprot:NANE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NANE_ECOLI pepstats swissprot:NANE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NANE_ECOLI pepwheel swissprot:NANE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NANE_ECOLI pepwindow swissprot:NANE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NANE_ECOLI sigcleave swissprot:NANE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NANE_ECOLI ## Database ID URL or Descriptions # AltName EUTH_ECOLI Putative ethanolamine transporter # BioGrid 4259191 8 # EcoGene EG14182 eutH # FUNCTION EUTH_ECOLI Possibly involved in the transport of ethanolamine from the periplasm to the cytoplasm. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0034228 ethanolamine transmembrane transporter activity; IEA:InterPro. # GO_process GO:0046336 ethanolamine catabolic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # InterPro IPR007441 EutH # Organism EUTH_ECOLI Escherichia coli (strain K12) # PATHWAY EUTH_ECOLI Amine and polyamine degradation; ethanolamine degradation. # PATRIC 32120287 VBIEscCol129921_2546 # PIR C65020 C65020 # PIRSF PIRSF019466 EutH # Pfam PF04346 EutH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EUTH_ECOLI Ethanolamine utilization protein EutH # RefSeq NP_416947 NC_000913.3 # RefSeq WP_000512372 NZ_LN832404.1 # SIMILARITY Belongs to the EutH family. {ECO 0000305}. # SUBCELLULAR LOCATION EUTH_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # eggNOG COG3192 LUCA # eggNOG ENOG4105ENY Bacteria BLAST swissprot:EUTH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EUTH_ECOLI BioCyc ECOL316407:JW2436-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2436-MONOMER BioCyc EcoCyc:G7282-MONOMER http://biocyc.org/getid?id=EcoCyc:G7282-MONOMER COG COG3192 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3192 DIP DIP-9533N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9533N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3934 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3934 EcoGene EG14182 http://www.ecogene.org/geneInfo.php?eg_id=EG14182 EnsemblBacteria AAC75505 http://www.ensemblgenomes.org/id/AAC75505 EnsemblBacteria AAC75505 http://www.ensemblgenomes.org/id/AAC75505 EnsemblBacteria BAA16330 http://www.ensemblgenomes.org/id/BAA16330 EnsemblBacteria BAA16330 http://www.ensemblgenomes.org/id/BAA16330 EnsemblBacteria BAA16330 http://www.ensemblgenomes.org/id/BAA16330 EnsemblBacteria b2452 http://www.ensemblgenomes.org/id/b2452 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0034228 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034228 GO_process GO:0046336 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046336 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 944979 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944979 HOGENOM HOG000289514 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000289514&db=HOGENOM6 InParanoid P76552 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76552 IntAct P76552 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76552* InterPro IPR007441 http://www.ebi.ac.uk/interpro/entry/IPR007441 KEGG_Gene ecj:JW2436 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2436 KEGG_Gene eco:b2452 http://www.genome.jp/dbget-bin/www_bget?eco:b2452 KEGG_Orthology KO:K04023 http://www.genome.jp/dbget-bin/www_bget?KO:K04023 MINT MINT-1296863 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1296863 OMA FGDHLGF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FGDHLGF PSORT swissprot:EUTH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EUTH_ECOLI PSORT-B swissprot:EUTH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EUTH_ECOLI PSORT2 swissprot:EUTH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EUTH_ECOLI Pfam PF04346 http://pfam.xfam.org/family/PF04346 Phobius swissprot:EUTH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EUTH_ECOLI PhylomeDB P76552 http://phylomedb.org/?seqid=P76552 ProteinModelPortal P76552 http://www.proteinmodelportal.org/query/uniprot/P76552 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416947 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416947 RefSeq WP_000512372 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000512372 STRING 511145.b2452 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2452&targetmode=cogs STRING COG3192 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3192&targetmode=cogs UniProtKB EUTH_ECOLI http://www.uniprot.org/uniprot/EUTH_ECOLI UniProtKB-AC P76552 http://www.uniprot.org/uniprot/P76552 charge swissprot:EUTH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EUTH_ECOLI eggNOG COG3192 http://eggnogapi.embl.de/nog_data/html/tree/COG3192 eggNOG ENOG4105ENY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ENY epestfind swissprot:EUTH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EUTH_ECOLI garnier swissprot:EUTH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EUTH_ECOLI helixturnhelix swissprot:EUTH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EUTH_ECOLI hmoment swissprot:EUTH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EUTH_ECOLI iep swissprot:EUTH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EUTH_ECOLI inforesidue swissprot:EUTH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EUTH_ECOLI octanol swissprot:EUTH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EUTH_ECOLI pepcoil swissprot:EUTH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EUTH_ECOLI pepdigest swissprot:EUTH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EUTH_ECOLI pepinfo swissprot:EUTH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EUTH_ECOLI pepnet swissprot:EUTH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EUTH_ECOLI pepstats swissprot:EUTH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EUTH_ECOLI pepwheel swissprot:EUTH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EUTH_ECOLI pepwindow swissprot:EUTH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EUTH_ECOLI sigcleave swissprot:EUTH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EUTH_ECOLI ## Database ID URL or Descriptions # BioGrid 4263068 176 # CDD cd06174 MFS # EcoGene EG13614 yajR # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_process GO:0006810 transport; IDA:EcoCyc. # GO_process GO:0055085 transmembrane transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # Organism YAJR_ECOLI Escherichia coli (strain K12) # PATRIC 32116005 VBIEscCol129921_0444 # PIR C64772 C64772 # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAJR_ECOLI Inner membrane transport protein YajR # RefSeq NP_414961 NC_000913.3 # RefSeq WP_001000963 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40183.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the major facilitator superfamily. {ECO 0000305}. # SUBCELLULAR LOCATION YAJR_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.2.60 the major facilitator superfamily (mfs) # eggNOG COG0477 LUCA # eggNOG ENOG4107RDB Bacteria BLAST swissprot:YAJR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAJR_ECOLI BioCyc ECOL316407:JW5059-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5059-MONOMER BioCyc EcoCyc:B0427-MONOMER http://biocyc.org/getid?id=EcoCyc:B0427-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EchoBASE EB3380 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3380 EcoGene EG13614 http://www.ecogene.org/geneInfo.php?eg_id=EG13614 EnsemblBacteria AAC73530 http://www.ensemblgenomes.org/id/AAC73530 EnsemblBacteria AAC73530 http://www.ensemblgenomes.org/id/AAC73530 EnsemblBacteria BAE76207 http://www.ensemblgenomes.org/id/BAE76207 EnsemblBacteria BAE76207 http://www.ensemblgenomes.org/id/BAE76207 EnsemblBacteria BAE76207 http://www.ensemblgenomes.org/id/BAE76207 EnsemblBacteria b0427 http://www.ensemblgenomes.org/id/b0427 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 945058 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945058 HOGENOM HOG000264695 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000264695&db=HOGENOM6 InParanoid P77726 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77726 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Gene ecj:JW5059 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5059 KEGG_Gene eco:b0427 http://www.genome.jp/dbget-bin/www_bget?eco:b0427 OMA PPYVTSL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PPYVTSL PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:YAJR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAJR_ECOLI PSORT-B swissprot:YAJR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAJR_ECOLI PSORT2 swissprot:YAJR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAJR_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:YAJR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAJR_ECOLI PhylomeDB P77726 http://phylomedb.org/?seqid=P77726 ProteinModelPortal P77726 http://www.proteinmodelportal.org/query/uniprot/P77726 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414961 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414961 RefSeq WP_001000963 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001000963 STRING 511145.b0427 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0427&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.2.60 http://www.tcdb.org/search/result.php?tc=2.A.1.2.60 UniProtKB YAJR_ECOLI http://www.uniprot.org/uniprot/YAJR_ECOLI UniProtKB-AC P77726 http://www.uniprot.org/uniprot/P77726 charge swissprot:YAJR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAJR_ECOLI eggNOG COG0477 http://eggnogapi.embl.de/nog_data/html/tree/COG0477 eggNOG ENOG4107RDB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107RDB epestfind swissprot:YAJR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAJR_ECOLI garnier swissprot:YAJR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAJR_ECOLI helixturnhelix swissprot:YAJR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAJR_ECOLI hmoment swissprot:YAJR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAJR_ECOLI iep swissprot:YAJR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAJR_ECOLI inforesidue swissprot:YAJR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAJR_ECOLI octanol swissprot:YAJR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAJR_ECOLI pepcoil swissprot:YAJR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAJR_ECOLI pepdigest swissprot:YAJR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAJR_ECOLI pepinfo swissprot:YAJR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAJR_ECOLI pepnet swissprot:YAJR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAJR_ECOLI pepstats swissprot:YAJR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAJR_ECOLI pepwheel swissprot:YAJR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAJR_ECOLI pepwindow swissprot:YAJR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAJR_ECOLI sigcleave swissprot:YAJR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAJR_ECOLI ## Database ID URL or Descriptions # BioGrid 4262613 21 # EcoGene EG11201 yigA # IntAct P23305 4 # InterPro IPR007435 DUF484 # Organism YIGA_ECOLI Escherichia coli (strain K12) # PATRIC 32123121 VBIEscCol129921_3926 # PIR B37841 B37841 # Pfam PF04340 DUF484 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIGA_ECOLI Uncharacterized protein YigA # RefSeq NP_418255 NC_000913.3 # RefSeq WP_000812796 NZ_LN832404.1 # eggNOG COG3159 LUCA # eggNOG ENOG4105CT0 Bacteria BLAST swissprot:YIGA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIGA_ECOLI BioCyc ECOL316407:JW3783-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3783-MONOMER BioCyc EcoCyc:EG11201-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11201-MONOMER COG COG3159 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3159 DIP DIP-12478N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12478N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M38257 http://www.ebi.ac.uk/ena/data/view/M38257 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1186 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1186 EcoGene EG11201 http://www.ecogene.org/geneInfo.php?eg_id=EG11201 EnsemblBacteria AAC76813 http://www.ensemblgenomes.org/id/AAC76813 EnsemblBacteria AAC76813 http://www.ensemblgenomes.org/id/AAC76813 EnsemblBacteria BAE77490 http://www.ensemblgenomes.org/id/BAE77490 EnsemblBacteria BAE77490 http://www.ensemblgenomes.org/id/BAE77490 EnsemblBacteria BAE77490 http://www.ensemblgenomes.org/id/BAE77490 EnsemblBacteria b3810 http://www.ensemblgenomes.org/id/b3810 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 948359 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948359 HOGENOM HOG000265997 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000265997&db=HOGENOM6 InParanoid P23305 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23305 IntAct P23305 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P23305* InterPro IPR007435 http://www.ebi.ac.uk/interpro/entry/IPR007435 KEGG_Gene ecj:JW3783 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3783 KEGG_Gene eco:b3810 http://www.genome.jp/dbget-bin/www_bget?eco:b3810 KEGG_Orthology KO:K09921 http://www.genome.jp/dbget-bin/www_bget?KO:K09921 OMA FHRWARE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FHRWARE PSORT swissprot:YIGA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIGA_ECOLI PSORT-B swissprot:YIGA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIGA_ECOLI PSORT2 swissprot:YIGA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIGA_ECOLI Pfam PF04340 http://pfam.xfam.org/family/PF04340 Phobius swissprot:YIGA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIGA_ECOLI ProteinModelPortal P23305 http://www.proteinmodelportal.org/query/uniprot/P23305 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2254268 http://www.ncbi.nlm.nih.gov/pubmed/2254268 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418255 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418255 RefSeq WP_000812796 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000812796 STRING 511145.b3810 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3810&targetmode=cogs STRING COG3159 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3159&targetmode=cogs UniProtKB YIGA_ECOLI http://www.uniprot.org/uniprot/YIGA_ECOLI UniProtKB-AC P23305 http://www.uniprot.org/uniprot/P23305 charge swissprot:YIGA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIGA_ECOLI eggNOG COG3159 http://eggnogapi.embl.de/nog_data/html/tree/COG3159 eggNOG ENOG4105CT0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CT0 epestfind swissprot:YIGA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIGA_ECOLI garnier swissprot:YIGA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIGA_ECOLI helixturnhelix swissprot:YIGA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIGA_ECOLI hmoment swissprot:YIGA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIGA_ECOLI iep swissprot:YIGA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIGA_ECOLI inforesidue swissprot:YIGA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIGA_ECOLI octanol swissprot:YIGA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIGA_ECOLI pepcoil swissprot:YIGA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIGA_ECOLI pepdigest swissprot:YIGA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIGA_ECOLI pepinfo swissprot:YIGA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIGA_ECOLI pepnet swissprot:YIGA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIGA_ECOLI pepstats swissprot:YIGA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIGA_ECOLI pepwheel swissprot:YIGA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIGA_ECOLI pepwindow swissprot:YIGA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIGA_ECOLI sigcleave swissprot:YIGA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIGA_ECOLI ## Database ID URL or Descriptions # AltName IBPB_ECOLI 16 kDa heat shock protein B # BIOPHYSICOCHEMICAL PROPERTIES Temperature dependence Thermostable up to 50 degrees Celsius.; # BioGrid 4260809 224 # DOMAIN IBPB_ECOLI The N- and C-terminal flexible termini are involved in oligomerization and in the binding of non-native substrate proteins, and are essential for chaperone activity. {ECO 0000269|PubMed 15769476}. # EcoGene EG11535 ibpB # FUNCTION IBPB_ECOLI Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP- independent. {ECO 0000269|PubMed 12055295, ECO 0000269|PubMed 12071954, ECO 0000269|PubMed 9556585}. # GO_component GO:0005737 cytoplasm; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0009408 response to heat; IMP:EcoCyc. # GO_process GO:0050821 protein stabilization; IEA:UniProtKB-HAMAP. # GO_process GO:1990169 stress response to copper ion; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # Gene3D 2.60.40.790 -; 1. # HAMAP MF_02001 HSP20_IbpB # INDUCTION By heat shock. {ECO:0000269|PubMed 1356969}. # INTERACTION IBPB_ECOLI Self; NbExp=3; IntAct=EBI-552784, EBI-552784; P0C054 ibpA; NbExp=3; IntAct=EBI-552784, EBI-550729; # IntAct P0C058 11 # InterPro IPR002068 A-crystallin/Hsp20_dom # InterPro IPR008978 HSP20-like_chaperone # InterPro IPR022848 HSP20_IbpB # InterPro IPR031107 HSP20 # KEGG_Brite ko03110 Chaperones and folding catalysts # Organism IBPB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11527 PTHR11527 # PATRIC 32122865 VBIEscCol129921_3808 # PROSITE PS01031 HSP20 # Pfam PF00011 HSP20 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName IBPB_ECOLI Small heat shock protein IbpB # RefSeq NP_418141 NC_000913.3 # RefSeq WP_001243431 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA62038.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the small heat shock protein (HSP20) family. {ECO 0000305}. # SUBCELLULAR LOCATION IBPB_ECOLI Cytoplasm {ECO 0000269|PubMed 14702418}. # SUBUNIT IBPB_ECOLI Homodimer. Forms homomultimers of about 100-150 subunits at optimal growth temperatures. Conformation changes to oligomers at high temperatures or high ionic concentrations. The decrease in size of the multimers is accompanied by an increase in chaperone activity. {ECO 0000269|PubMed 10187768, ECO 0000269|PubMed 12071954, ECO 0000269|PubMed 15769476}. # SUPFAM SSF49764 SSF49764 # eggNOG COG0071 LUCA # eggNOG ENOG4108SHS Bacteria BLAST swissprot:IBPB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:IBPB_ECOLI BioCyc ECOL316407:JW3663-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3663-MONOMER BioCyc EcoCyc:EG11535-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11535-MONOMER COG COG0071 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0071 DIP DIP-48244N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48244N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1016/j.jmb.2005.01.029 http://dx.doi.org/10.1016/j.jmb.2005.01.029 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2003.03710.x http://dx.doi.org/10.1046/j.1365-2958.2003.03710.x DOI 10.1046/j.1432-1033.2002.02958.x http://dx.doi.org/10.1046/j.1432-1033.2002.02958.x DOI 10.1074/jbc.273.18.11032 http://dx.doi.org/10.1074/jbc.273.18.11032 DOI 10.1074/jbc.274.15.9937 http://dx.doi.org/10.1074/jbc.274.15.9937 DOI 10.1074/jbc.M412706200 http://dx.doi.org/10.1074/jbc.M412706200 DOI 10.1099/mic.0.26470-0 http://dx.doi.org/10.1099/mic.0.26470-0 DOI 10.1111/j.1574-6968.2000.tb09009.x http://dx.doi.org/10.1111/j.1574-6968.2000.tb09009.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M94104 http://www.ebi.ac.uk/ena/data/view/M94104 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1497 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1497 EcoGene EG11535 http://www.ecogene.org/geneInfo.php?eg_id=EG11535 EnsemblBacteria AAC76709 http://www.ensemblgenomes.org/id/AAC76709 EnsemblBacteria AAC76709 http://www.ensemblgenomes.org/id/AAC76709 EnsemblBacteria BAE77608 http://www.ensemblgenomes.org/id/BAE77608 EnsemblBacteria BAE77608 http://www.ensemblgenomes.org/id/BAE77608 EnsemblBacteria BAE77608 http://www.ensemblgenomes.org/id/BAE77608 EnsemblBacteria b3686 http://www.ensemblgenomes.org/id/b3686 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GO_process GO:0050821 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050821 GO_process GO:1990169 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990169 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 2.60.40.790 http://www.cathdb.info/version/latest/superfamily/2.60.40.790 GeneID 948192 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948192 HAMAP MF_02001 http://hamap.expasy.org/unirule/MF_02001 HOGENOM HOG000251750 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000251750&db=HOGENOM6 InParanoid P0C058 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0C058 IntAct P0C058 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0C058* InterPro IPR002068 http://www.ebi.ac.uk/interpro/entry/IPR002068 InterPro IPR008978 http://www.ebi.ac.uk/interpro/entry/IPR008978 InterPro IPR022848 http://www.ebi.ac.uk/interpro/entry/IPR022848 InterPro IPR031107 http://www.ebi.ac.uk/interpro/entry/IPR031107 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW3663 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3663 KEGG_Gene eco:b3686 http://www.genome.jp/dbget-bin/www_bget?eco:b3686 KEGG_Orthology KO:K04081 http://www.genome.jp/dbget-bin/www_bget?KO:K04081 MINT MINT-1223453 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1223453 OMA KESEYLH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KESEYLH PANTHER PTHR11527 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11527 PROSITE PS01031 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01031 PSORT swissprot:IBPB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:IBPB_ECOLI PSORT-B swissprot:IBPB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:IBPB_ECOLI PSORT2 swissprot:IBPB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:IBPB_ECOLI Pfam PF00011 http://pfam.xfam.org/family/PF00011 Phobius swissprot:IBPB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:IBPB_ECOLI PhylomeDB P0C058 http://phylomedb.org/?seqid=P0C058 ProteinModelPortal P0C058 http://www.proteinmodelportal.org/query/uniprot/P0C058 PubMed 10187768 http://www.ncbi.nlm.nih.gov/pubmed/10187768 PubMed 10713416 http://www.ncbi.nlm.nih.gov/pubmed/10713416 PubMed 12055295 http://www.ncbi.nlm.nih.gov/pubmed/12055295 PubMed 12071954 http://www.ncbi.nlm.nih.gov/pubmed/12071954 PubMed 1356969 http://www.ncbi.nlm.nih.gov/pubmed/1356969 PubMed 14617181 http://www.ncbi.nlm.nih.gov/pubmed/14617181 PubMed 14702418 http://www.ncbi.nlm.nih.gov/pubmed/14702418 PubMed 15665332 http://www.ncbi.nlm.nih.gov/pubmed/15665332 PubMed 15769476 http://www.ncbi.nlm.nih.gov/pubmed/15769476 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9556585 http://www.ncbi.nlm.nih.gov/pubmed/9556585 RefSeq NP_418141 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418141 RefSeq WP_001243431 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001243431 SMR P0C058 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0C058 STRING 511145.b3686 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3686&targetmode=cogs STRING COG0071 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0071&targetmode=cogs SUPFAM SSF49764 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49764 UniProtKB IBPB_ECOLI http://www.uniprot.org/uniprot/IBPB_ECOLI UniProtKB-AC P0C058 http://www.uniprot.org/uniprot/P0C058 charge swissprot:IBPB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:IBPB_ECOLI eggNOG COG0071 http://eggnogapi.embl.de/nog_data/html/tree/COG0071 eggNOG ENOG4108SHS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108SHS epestfind swissprot:IBPB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:IBPB_ECOLI garnier swissprot:IBPB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:IBPB_ECOLI helixturnhelix swissprot:IBPB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:IBPB_ECOLI hmoment swissprot:IBPB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:IBPB_ECOLI iep swissprot:IBPB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:IBPB_ECOLI inforesidue swissprot:IBPB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:IBPB_ECOLI octanol swissprot:IBPB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:IBPB_ECOLI pepcoil swissprot:IBPB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:IBPB_ECOLI pepdigest swissprot:IBPB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:IBPB_ECOLI pepinfo swissprot:IBPB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:IBPB_ECOLI pepnet swissprot:IBPB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:IBPB_ECOLI pepstats swissprot:IBPB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:IBPB_ECOLI pepwheel swissprot:IBPB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:IBPB_ECOLI pepwindow swissprot:IBPB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:IBPB_ECOLI sigcleave swissprot:IBPB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:IBPB_ECOLI ## Database ID URL or Descriptions # BioGrid 4261847 4 # CAUTION Was originally thought to be plasmid encoded. {ECO:0000305|PubMed 2060788}. # EcoGene EG11883 tehA # FUNCTION TEHA_ECOLI Responsible for potassium tellurite resistance when present in high copy number. Ion channel involved in potassium tellurite resistance (By similarity). Otherwise, phenotypically silent. {ECO 0000250}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0046583 cation efflux transmembrane transporter activity; IDA:EcoCyc. # GO_process GO:0006812 cation transport; IDA:EcoCyc. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GO_process GO:0046690 response to tellurium ion; IMP:EcoCyc. # GO_process GO:0055085 transmembrane transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # GOslim_process GO:0055085 transmembrane transport # InterPro IPR004695 Voltage-dep_anion_channel # InterPro IPR011552 TehA/Mae1 # Organism TEHA_ECOLI Escherichia coli (strain K12) # PATRIC 32118142 VBIEscCol129921_1491 # PIR H64894 H64894 # Pfam PF03595 SLAC1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TEHA_ECOLI Tellurite resistance protein TehA # RefSeq NP_415946 NC_000913.3 # SIMILARITY Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family. {ECO 0000305}. # SUBCELLULAR LOCATION TEHA_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT Homotrimer. Each subunit forms a channel (By similarity). {ECO 0000250}. # TCDB 2.A.16.1 the telurite-resistance/dicarboxylate transporter (tdt) family # TIGRFAMs TIGR00816 tdt # eggNOG COG1275 LUCA # eggNOG ENOG4108NKP Bacteria BLAST swissprot:TEHA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TEHA_ECOLI BioCyc ECOL316407:JW1425-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1425-MONOMER BioCyc EcoCyc:TEHA-MONOMER http://biocyc.org/getid?id=EcoCyc:TEHA-MONOMER BioCyc MetaCyc:TEHA-MONOMER http://biocyc.org/getid?id=MetaCyc:TEHA-MONOMER COG COG1275 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1275 DIP DIP-10977N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10977N DOI 10.1016/0378-1119(91)90217-Y http://dx.doi.org/10.1016/0378-1119(91)90217-Y DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M74072 http://www.ebi.ac.uk/ena/data/view/M74072 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1829 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1829 EcoGene EG11883 http://www.ecogene.org/geneInfo.php?eg_id=EG11883 EnsemblBacteria AAC74511 http://www.ensemblgenomes.org/id/AAC74511 EnsemblBacteria AAC74511 http://www.ensemblgenomes.org/id/AAC74511 EnsemblBacteria BAA15058 http://www.ensemblgenomes.org/id/BAA15058 EnsemblBacteria BAA15058 http://www.ensemblgenomes.org/id/BAA15058 EnsemblBacteria BAA15058 http://www.ensemblgenomes.org/id/BAA15058 EnsemblBacteria b1429 http://www.ensemblgenomes.org/id/b1429 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0046583 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046583 GO_process GO:0006812 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006812 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GO_process GO:0046690 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046690 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 945852 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945852 HOGENOM HOG000120585 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120585&db=HOGENOM6 InParanoid P25396 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P25396 InterPro IPR004695 http://www.ebi.ac.uk/interpro/entry/IPR004695 InterPro IPR011552 http://www.ebi.ac.uk/interpro/entry/IPR011552 KEGG_Gene ecj:JW1425 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1425 KEGG_Gene eco:b1429 http://www.genome.jp/dbget-bin/www_bget?eco:b1429 KEGG_Orthology KO:K03304 http://www.genome.jp/dbget-bin/www_bget?KO:K03304 OMA WIALFTI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WIALFTI PSORT swissprot:TEHA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TEHA_ECOLI PSORT-B swissprot:TEHA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TEHA_ECOLI PSORT2 swissprot:TEHA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TEHA_ECOLI Pfam PF03595 http://pfam.xfam.org/family/PF03595 Phobius swissprot:TEHA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TEHA_ECOLI PhylomeDB P25396 http://phylomedb.org/?seqid=P25396 ProteinModelPortal P25396 http://www.proteinmodelportal.org/query/uniprot/P25396 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2060788 http://www.ncbi.nlm.nih.gov/pubmed/2060788 PubMed 8169225 http://www.ncbi.nlm.nih.gov/pubmed/8169225 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415946 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415946 STRING 511145.b1429 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1429&targetmode=cogs STRING COG1275 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1275&targetmode=cogs TCDB 2.A.16.1 http://www.tcdb.org/search/result.php?tc=2.A.16.1 TIGRFAMs TIGR00816 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00816 UniProtKB TEHA_ECOLI http://www.uniprot.org/uniprot/TEHA_ECOLI UniProtKB-AC P25396 http://www.uniprot.org/uniprot/P25396 charge swissprot:TEHA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TEHA_ECOLI eggNOG COG1275 http://eggnogapi.embl.de/nog_data/html/tree/COG1275 eggNOG ENOG4108NKP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108NKP epestfind swissprot:TEHA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TEHA_ECOLI garnier swissprot:TEHA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TEHA_ECOLI helixturnhelix swissprot:TEHA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TEHA_ECOLI hmoment swissprot:TEHA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TEHA_ECOLI iep swissprot:TEHA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TEHA_ECOLI inforesidue swissprot:TEHA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TEHA_ECOLI octanol swissprot:TEHA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TEHA_ECOLI pepcoil swissprot:TEHA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TEHA_ECOLI pepdigest swissprot:TEHA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TEHA_ECOLI pepinfo swissprot:TEHA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TEHA_ECOLI pepnet swissprot:TEHA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TEHA_ECOLI pepstats swissprot:TEHA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TEHA_ECOLI pepwheel swissprot:TEHA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TEHA_ECOLI pepwindow swissprot:TEHA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TEHA_ECOLI sigcleave swissprot:TEHA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TEHA_ECOLI ## Database ID URL or Descriptions # AltName NRFA_ECOLI Ammonia-forming cytochrome c nitrite reductase # BIOPHYSICOCHEMICAL PROPERTIES NRFA_ECOLI Kinetic parameters KM=28 uM for nitrite {ECO 0000269|PubMed 11863430}; KM=30 uM for nitrite {ECO 0000269|PubMed 18311941}; KM=22 uM for nitrite {ECO 0000269|PubMed 20629638}; KM=70 uM for sulfite {ECO 0000269|PubMed 20629638}; KM=30 mM for hydroxylamine {ECO 0000269|PubMed 11863430}; # BRENDA 1.7.2 2026 # BioGrid 4259405 10 # CATALYTIC ACTIVITY NRFA_ECOLI NH(3) + 2 H(2)O + 6 ferricytochrome c = nitrite + 6 ferrocytochrome c + 7 H(+). {ECO 0000269|PubMed 11863430, ECO 0000269|PubMed 18311941, ECO 0000269|PubMed 20629638, ECO 0000269|PubMed 9593308}. # COFACTOR NRFA_ECOLI Name=Ca(2+); Xref=ChEBI CHEBI 29108; Evidence={ECO 0000269|PubMed 11863430, ECO 0000269|PubMed 18311941, ECO 0000269|PubMed 20629638, ECO 0000269|PubMed 22103542}; Note=Binds 1 Ca(2+) ion per monomer. {ECO 0000269|PubMed 11863430, ECO 0000269|PubMed 18311941, ECO 0000269|PubMed 20629638, ECO 0000269|PubMed 22103542}; # COFACTOR NRFA_ECOLI Name=heme; Xref=ChEBI CHEBI 30413; Evidence={ECO 0000269|PubMed 11863430, ECO 0000269|PubMed 18311941, ECO 0000269|PubMed 20629638, ECO 0000269|PubMed 22103542, ECO 0000269|PubMed 7934939, ECO 0000269|PubMed 9593308}; Note=Binds 5 heme groups covalently per monomer. {ECO 0000269|PubMed 11863430, ECO 0000269|PubMed 18311941, ECO 0000269|PubMed 20629638, ECO 0000269|PubMed 22103542}; # ENZYME REGULATION Subject to competitive inhibition by sulfite. {ECO:0000269|PubMed 20629638}. # EcoGene EG11781 nrfA # FUNCTION NRFA_ECOLI Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process (PubMed 9593308, PubMed 11863430, PubMed 18311941, PubMed 20629638). Has very low activity toward hydroxylamine (PubMed 11863430). Has even lower activity toward sulfite (PubMed 20629638). Sulfite reductase activity is maximal at neutral pH (By similarity). {ECO 0000250|UniProtKB L0DSL2, ECO 0000269|PubMed 11863430, ECO 0000269|PubMed 18311941, ECO 0000269|PubMed 20629638, ECO 0000269|PubMed 9593308, ECO 0000305|PubMed 7934939}. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0005506 iron ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0005509 calcium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0016966 nitric oxide reductase activity; IDA:CACAO. # GO_function GO:0020037 heme binding; IDA:EcoCyc. # GO_function GO:0042279 nitrite reductase (cytochrome, ammonia-forming) activity; IDA:EcoCyc. # GO_process GO:0019645 anaerobic electron transport chain; IMP:EcoCyc. # GO_process GO:0042128 nitrate assimilation; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0071941 nitrogen cycle metabolic process # Gene3D 1.10.710.10 -; 1. # HAMAP MF_01182 Cytochrom_C552 # INDUCTION Full induction attained in the presence of nitrite. Subject to glucose and nitrate repression. {ECO:0000269|PubMed 7934939}. # IntAct P0ABK9 3 # InterPro IPR003321 Cyt_c552 # InterPro IPR011031 Multihaem_cyt # InterPro IPR017570 Cyt_c_NO2Rdtase_formate-dep # InterPro IPR023155 Cyt_c-552/4 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00910 Nitrogen metabolism # KEGG_Pathway ko05132 Salmonella infection # MASS SPECTROMETRY Mass=53590; Method=MALDI; Range=27-478; Evidence={ECO:0000269|PubMed 9593308}; # Organism NRFA_ECOLI Escherichia coli (strain K12) # PATHWAY Nitrogen metabolism; nitrate reduction (assimilation). {ECO:0000305|PubMed 7934939}. # PATRIC 32123689 VBIEscCol129921_4193 # PDB 1GU6 X-ray; 2.50 A; A/C/E/G=27-478 # PDB 2RDZ X-ray; 1.74 A; A/B/C/D=27-478 # PDB 2RF7 X-ray; 2.04 A; A/B/C/D=37-477 # PDB 3L1T X-ray; 2.30 A; A/B/C/D=27-478 # PDB 3TOR X-ray; 2.00 A; A/B/C/D=27-478 # PDB 4WJY X-ray; 2.15 A; A/B=27-478 # PIR S39590 S39590 # PIRSF PIRSF000243 Cyt_c552 # PROSITE PS51008 MULTIHEME_CYTC # Pfam PF02335 Cytochrom_C552 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Cytochrome c-552 {ECO:0000303|PubMed 7934939} # RefSeq NP_418494 NC_000913.3 # RefSeq WP_000196875 NZ_LN832404.1 # SIMILARITY Belongs to the cytochrome c-552 family. {ECO 0000305}. # SUBCELLULAR LOCATION NRFA_ECOLI Periplasm {ECO 0000269|PubMed 11863430, ECO 0000269|PubMed 7934939}. # SUBUNIT NRFA_ECOLI Homodimer (PubMed 11863430, PubMed 18311941). Component of a membrane-associated heterooligomeric complex (Probable). {ECO 0000269|PubMed 11863430, ECO 0000269|PubMed 18311941, ECO 0000305}. # SUPFAM SSF48695 SSF48695 # TIGRFAMs TIGR03152 cyto_c552_HCOOH # eggNOG COG3303 LUCA # eggNOG ENOG4105EAU Bacteria BLAST swissprot:NRFA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NRFA_ECOLI BioCyc ECOL316407:JW4031-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4031-MONOMER BioCyc EcoCyc:CYTOCHROMEC552-MONOMER http://biocyc.org/getid?id=EcoCyc:CYTOCHROMEC552-MONOMER BioCyc MetaCyc:CYTOCHROMEC552-MONOMER http://biocyc.org/getid?id=MetaCyc:CYTOCHROMEC552-MONOMER COG COG3303 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3303 DIP DIP-36021N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36021N DOI 10.1021/bi015765d http://dx.doi.org/10.1021/bi015765d DOI 10.1021/bi702175w http://dx.doi.org/10.1021/bi702175w DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/BJ20100866 http://dx.doi.org/10.1042/BJ20100866 DOI 10.1042/BST20110731 http://dx.doi.org/10.1042/BST20110731 DOI 10.1046/j.1365-2958.1998.00792.x http://dx.doi.org/10.1046/j.1365-2958.1998.00792.x DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1111/j.1365-2958.1993.tb01255.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb01255.x DOI 10.1111/j.1574-6968.1994.tb06872.x http://dx.doi.org/10.1111/j.1574-6968.1994.tb06872.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.7.2.2 {ECO:0000269|PubMed:11863430, ECO:0000269|PubMed:18311941, ECO:0000269|PubMed:20629638, ECO:0000269|PubMed:9593308} http://www.genome.jp/dbget-bin/www_bget?EC:1.7.2.2 {ECO:0000269|PubMed:11863430, ECO:0000269|PubMed:18311941, ECO:0000269|PubMed:20629638, ECO:0000269|PubMed:9593308} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X72298 http://www.ebi.ac.uk/ena/data/view/X72298 ENZYME 1.7.2.2 {ECO:0000269|PubMed:11863430, ECO:0000269|PubMed:18311941, ECO:0000269|PubMed:20629638, ECO:0000269|PubMed:9593308} http://enzyme.expasy.org/EC/1.7.2.2 {ECO:0000269|PubMed:11863430, ECO:0000269|PubMed:18311941, ECO:0000269|PubMed:20629638, ECO:0000269|PubMed:9593308} EchoBASE EB1729 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1729 EcoGene EG11781 http://www.ecogene.org/geneInfo.php?eg_id=EG11781 EnsemblBacteria AAC77040 http://www.ensemblgenomes.org/id/AAC77040 EnsemblBacteria AAC77040 http://www.ensemblgenomes.org/id/AAC77040 EnsemblBacteria BAE78072 http://www.ensemblgenomes.org/id/BAE78072 EnsemblBacteria BAE78072 http://www.ensemblgenomes.org/id/BAE78072 EnsemblBacteria BAE78072 http://www.ensemblgenomes.org/id/BAE78072 EnsemblBacteria b4070 http://www.ensemblgenomes.org/id/b4070 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0005509 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509 GO_function GO:0016966 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016966 GO_function GO:0020037 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0020037 GO_function GO:0042279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042279 GO_process GO:0019645 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019645 GO_process GO:0042128 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042128 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0071941 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071941 Gene3D 1.10.710.10 http://www.cathdb.info/version/latest/superfamily/1.10.710.10 GeneID 948571 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948571 HAMAP MF_01182 http://hamap.expasy.org/unirule/MF_01182 HOGENOM HOG000278511 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278511&db=HOGENOM6 InParanoid P0ABK9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABK9 IntAct P0ABK9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABK9* IntEnz 1.7.2.2 {ECO:0000269|PubMed:11863430, ECO:0000269|PubMed:18311941, ECO:0000269|PubMed:20629638, ECO:0000269|PubMed:9593308} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.7.2.2 {ECO:0000269|PubMed:11863430, ECO:0000269|PubMed:18311941, ECO:0000269|PubMed:20629638, ECO:0000269|PubMed:9593308} InterPro IPR003321 http://www.ebi.ac.uk/interpro/entry/IPR003321 InterPro IPR011031 http://www.ebi.ac.uk/interpro/entry/IPR011031 InterPro IPR017570 http://www.ebi.ac.uk/interpro/entry/IPR017570 InterPro IPR023155 http://www.ebi.ac.uk/interpro/entry/IPR023155 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4031 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4031 KEGG_Gene eco:b4070 http://www.genome.jp/dbget-bin/www_bget?eco:b4070 KEGG_Orthology KO:K03385 http://www.genome.jp/dbget-bin/www_bget?KO:K03385 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Pathway ko05132 http://www.genome.jp/kegg-bin/show_pathway?ko05132 KEGG_Reaction rn:R05712 http://www.genome.jp/dbget-bin/www_bget?rn:R05712 OMA CHEKGKS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CHEKGKS PDB 1GU6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1GU6 PDB 2RDZ http://www.ebi.ac.uk/pdbe-srv/view/entry/2RDZ PDB 2RF7 http://www.ebi.ac.uk/pdbe-srv/view/entry/2RF7 PDB 3L1T http://www.ebi.ac.uk/pdbe-srv/view/entry/3L1T PDB 3TOR http://www.ebi.ac.uk/pdbe-srv/view/entry/3TOR PDB 4WJY http://www.ebi.ac.uk/pdbe-srv/view/entry/4WJY PDBsum 1GU6 http://www.ebi.ac.uk/pdbsum/1GU6 PDBsum 2RDZ http://www.ebi.ac.uk/pdbsum/2RDZ PDBsum 2RF7 http://www.ebi.ac.uk/pdbsum/2RF7 PDBsum 3L1T http://www.ebi.ac.uk/pdbsum/3L1T PDBsum 3TOR http://www.ebi.ac.uk/pdbsum/3TOR PDBsum 4WJY http://www.ebi.ac.uk/pdbsum/4WJY PROSITE PS51008 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51008 PSORT swissprot:NRFA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NRFA_ECOLI PSORT-B swissprot:NRFA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NRFA_ECOLI PSORT2 swissprot:NRFA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NRFA_ECOLI Pfam PF02335 http://pfam.xfam.org/family/PF02335 Phobius swissprot:NRFA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NRFA_ECOLI PhylomeDB P0ABK9 http://phylomedb.org/?seqid=P0ABK9 ProteinModelPortal P0ABK9 http://www.proteinmodelportal.org/query/uniprot/P0ABK9 PubMed 11863430 http://www.ncbi.nlm.nih.gov/pubmed/11863430 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18311941 http://www.ncbi.nlm.nih.gov/pubmed/18311941 PubMed 20629638 http://www.ncbi.nlm.nih.gov/pubmed/20629638 PubMed 22103542 http://www.ncbi.nlm.nih.gov/pubmed/22103542 PubMed 7934939 http://www.ncbi.nlm.nih.gov/pubmed/7934939 PubMed 8039676 http://www.ncbi.nlm.nih.gov/pubmed/8039676 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9593308 http://www.ncbi.nlm.nih.gov/pubmed/9593308 RefSeq NP_418494 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418494 RefSeq WP_000196875 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000196875 SMR P0ABK9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABK9 STRING 511145.b4070 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4070&targetmode=cogs STRING COG3303 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3303&targetmode=cogs SUPFAM SSF48695 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48695 TIGRFAMs TIGR03152 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03152 UniProtKB NRFA_ECOLI http://www.uniprot.org/uniprot/NRFA_ECOLI UniProtKB-AC P0ABK9 http://www.uniprot.org/uniprot/P0ABK9 charge swissprot:NRFA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NRFA_ECOLI eggNOG COG3303 http://eggnogapi.embl.de/nog_data/html/tree/COG3303 eggNOG ENOG4105EAU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EAU epestfind swissprot:NRFA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NRFA_ECOLI garnier swissprot:NRFA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NRFA_ECOLI helixturnhelix swissprot:NRFA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NRFA_ECOLI hmoment swissprot:NRFA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NRFA_ECOLI iep swissprot:NRFA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NRFA_ECOLI inforesidue swissprot:NRFA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NRFA_ECOLI octanol swissprot:NRFA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NRFA_ECOLI pepcoil swissprot:NRFA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NRFA_ECOLI pepdigest swissprot:NRFA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NRFA_ECOLI pepinfo swissprot:NRFA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NRFA_ECOLI pepnet swissprot:NRFA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NRFA_ECOLI pepstats swissprot:NRFA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NRFA_ECOLI pepwheel swissprot:NRFA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NRFA_ECOLI pepwindow swissprot:NRFA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NRFA_ECOLI sigcleave swissprot:NRFA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NRFA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261134 9 # DISRUPTION PHENOTYPE Mutants show a significant accumulation of intracellular L-alanine and a reduction in the L-alanine export rate. {ECO:0000269|PubMed 21531828}. # EcoGene EG13525 alaE # FUNCTION ALAE_ECOLI Exports L-alanine. {ECO 0000255|HAMAP-Rule MF_00914, ECO 0000269|PubMed 21531828}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IEA:UniProtKB-HAMAP. # GO_component GO:0016021 integral component of membrane; IDA:EcoCyc. # GO_function GO:0034639 L-amino acid efflux transmembrane transporter activity; IEA:UniProtKB-HAMAP. # GO_process GO:0032973 amino acid export; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # HAMAP MF_00914 L_Ala_exporter # INDUCTION Induced in the presence of L-alanyl-L-alanine dipeptides. {ECO:0000269|PubMed 21531828}. # InterPro IPR010574 Ala_export_AlaE # Organism ALAE_ECOLI Escherichia coli (strain K12) # PATRIC 32120730 VBIEscCol129921_2762 # PIR G65046 G65046 # Pfam PF06610 AlaE # ProDom PD090021 DUF1144 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName L-alanine exporter AlaE {ECO:0000255|HAMAP-Rule MF_00914} # RefSeq NP_417156 NC_000913.3 # RefSeq WP_000492656 NZ_LN832404.1 # SIMILARITY Belongs to the AlaE exporter family. {ECO:0000255|HAMAP-Rule MF_00914}. # SUBCELLULAR LOCATION ALAE_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_00914, ECO 0000269|PubMed 21531828}; Multi-pass membrane protein {ECO 0000255|HAMAP-Rule MF_00914, ECO 0000269|PubMed 21531828}. # eggNOG ENOG4108RNS Bacteria # eggNOG ENOG4111J5P LUCA BLAST swissprot:ALAE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ALAE_ECOLI BioCyc ECOL316407:JW2645-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2645-MONOMER BioCyc EcoCyc:G7399-MONOMER http://biocyc.org/getid?id=EcoCyc:G7399-MONOMER BioCyc MetaCyc:G7399-MONOMER http://biocyc.org/getid?id=MetaCyc:G7399-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AEM.00003-11 http://dx.doi.org/10.1128/AEM.00003-11 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3297 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3297 EcoGene EG13525 http://www.ecogene.org/geneInfo.php?eg_id=EG13525 EnsemblBacteria AAC75717 http://www.ensemblgenomes.org/id/AAC75717 EnsemblBacteria AAC75717 http://www.ensemblgenomes.org/id/AAC75717 EnsemblBacteria BAE76781 http://www.ensemblgenomes.org/id/BAE76781 EnsemblBacteria BAE76781 http://www.ensemblgenomes.org/id/BAE76781 EnsemblBacteria BAE76781 http://www.ensemblgenomes.org/id/BAE76781 EnsemblBacteria b2670 http://www.ensemblgenomes.org/id/b2670 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0034639 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034639 GO_process GO:0032973 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032973 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 947147 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947147 HAMAP MF_00914 http://hamap.expasy.org/unirule/MF_00914 HOGENOM HOG000123992 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000123992&db=HOGENOM6 InterPro IPR010574 http://www.ebi.ac.uk/interpro/entry/IPR010574 KEGG_Gene ecj:JW2645 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2645 KEGG_Gene eco:b2670 http://www.genome.jp/dbget-bin/www_bget?eco:b2670 OMA ADWHQIA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ADWHQIA PSORT swissprot:ALAE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ALAE_ECOLI PSORT-B swissprot:ALAE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ALAE_ECOLI PSORT2 swissprot:ALAE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ALAE_ECOLI Pfam PF06610 http://pfam.xfam.org/family/PF06610 Phobius swissprot:ALAE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ALAE_ECOLI ProteinModelPortal P64550 http://www.proteinmodelportal.org/query/uniprot/P64550 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21531828 http://www.ncbi.nlm.nih.gov/pubmed/21531828 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417156 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417156 RefSeq WP_000492656 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000492656 STRING 511145.b2670 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2670&targetmode=cogs UniProtKB ALAE_ECOLI http://www.uniprot.org/uniprot/ALAE_ECOLI UniProtKB-AC P64550 http://www.uniprot.org/uniprot/P64550 charge swissprot:ALAE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ALAE_ECOLI eggNOG ENOG4108RNS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108RNS eggNOG ENOG4111J5P http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111J5P epestfind swissprot:ALAE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ALAE_ECOLI garnier swissprot:ALAE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ALAE_ECOLI helixturnhelix swissprot:ALAE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ALAE_ECOLI hmoment swissprot:ALAE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ALAE_ECOLI iep swissprot:ALAE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ALAE_ECOLI inforesidue swissprot:ALAE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ALAE_ECOLI octanol swissprot:ALAE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ALAE_ECOLI pepcoil swissprot:ALAE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ALAE_ECOLI pepdigest swissprot:ALAE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ALAE_ECOLI pepinfo swissprot:ALAE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ALAE_ECOLI pepnet swissprot:ALAE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ALAE_ECOLI pepstats swissprot:ALAE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ALAE_ECOLI pepwheel swissprot:ALAE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ALAE_ECOLI pepwindow swissprot:ALAE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ALAE_ECOLI sigcleave swissprot:ALAE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ALAE_ECOLI ## Database ID URL or Descriptions # BioGrid 4261242 128 # CDD cd06174 MFS # EcoGene EG11693 emrD # FUNCTION EMRD_ECOLI Multidrug resistance pump that participates in a low energy shock adaptive response. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015238 drug transmembrane transporter activity; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # InterPro IPR004734 Multidrug-R # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # KEGG_Brite ko02000 Transporters # Organism EMRD_ECOLI Escherichia coli (strain K12) # PATRIC 32122837 VBIEscCol129921_3794 # PDB 2GFP X-ray; 3.50 A; A/B=9-383 # PIR B65169 B65169 # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EMRD_ECOLI Multidrug resistance protein D # RefSeq NP_418129 NC_000913.3 # RefSeq WP_000828746 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA62025.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the major facilitator superfamily. {ECO 0000305}. # SUBCELLULAR LOCATION EMRD_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.2 the major facilitator superfamily (mfs) # TIGRFAMs TIGR00880 2_A_01_02 # eggNOG ENOG4105E5M Bacteria # eggNOG ENOG410XQPV LUCA BLAST swissprot:EMRD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EMRD_ECOLI BioCyc ECOL316407:JW5634-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5634-MONOMER BioCyc EcoCyc:EMRD-MONOMER http://biocyc.org/getid?id=EcoCyc:EMRD-MONOMER COG COG0477 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0477 DOI 10.1006/bbrc.1993.2320 http://dx.doi.org/10.1006/bbrc.1993.2320 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1644 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1644 EcoGene EG11693 http://www.ecogene.org/geneInfo.php?eg_id=EG11693 EnsemblBacteria AAC76696 http://www.ensemblgenomes.org/id/AAC76696 EnsemblBacteria AAC76696 http://www.ensemblgenomes.org/id/AAC76696 EnsemblBacteria BAE77620 http://www.ensemblgenomes.org/id/BAE77620 EnsemblBacteria BAE77620 http://www.ensemblgenomes.org/id/BAE77620 EnsemblBacteria BAE77620 http://www.ensemblgenomes.org/id/BAE77620 EnsemblBacteria b3673 http://www.ensemblgenomes.org/id/b3673 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015238 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015238 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GeneID 948180 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948180 HOGENOM HOG000276020 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276020&db=HOGENOM6 InParanoid P31442 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31442 InterPro IPR004734 http://www.ebi.ac.uk/interpro/entry/IPR004734 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5634 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5634 KEGG_Gene eco:b3673 http://www.genome.jp/dbget-bin/www_bget?eco:b3673 KEGG_Orthology KO:K08154 http://www.genome.jp/dbget-bin/www_bget?KO:K08154 OMA GLNSMTV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GLNSMTV PDB 2GFP http://www.ebi.ac.uk/pdbe-srv/view/entry/2GFP PDBsum 2GFP http://www.ebi.ac.uk/pdbsum/2GFP PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:EMRD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EMRD_ECOLI PSORT-B swissprot:EMRD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EMRD_ECOLI PSORT2 swissprot:EMRD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EMRD_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:EMRD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EMRD_ECOLI PhylomeDB P31442 http://phylomedb.org/?seqid=P31442 ProteinModelPortal P31442 http://www.proteinmodelportal.org/query/uniprot/P31442 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 8240355 http://www.ncbi.nlm.nih.gov/pubmed/8240355 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418129 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418129 RefSeq WP_000828746 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000828746 SMR P31442 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31442 STRING 511145.b3673 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3673&targetmode=cogs STRING COG0477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0477&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.2 http://www.tcdb.org/search/result.php?tc=2.A.1.2 TIGRFAMs TIGR00880 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00880 UniProtKB EMRD_ECOLI http://www.uniprot.org/uniprot/EMRD_ECOLI UniProtKB-AC P31442 http://www.uniprot.org/uniprot/P31442 charge swissprot:EMRD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EMRD_ECOLI eggNOG ENOG4105E5M http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E5M eggNOG ENOG410XQPV http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQPV epestfind swissprot:EMRD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EMRD_ECOLI garnier swissprot:EMRD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EMRD_ECOLI helixturnhelix swissprot:EMRD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EMRD_ECOLI hmoment swissprot:EMRD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EMRD_ECOLI iep swissprot:EMRD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EMRD_ECOLI inforesidue swissprot:EMRD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EMRD_ECOLI octanol swissprot:EMRD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EMRD_ECOLI pepcoil swissprot:EMRD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EMRD_ECOLI pepdigest swissprot:EMRD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EMRD_ECOLI pepinfo swissprot:EMRD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EMRD_ECOLI pepnet swissprot:EMRD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EMRD_ECOLI pepstats swissprot:EMRD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EMRD_ECOLI pepwheel swissprot:EMRD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EMRD_ECOLI pepwindow swissprot:EMRD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EMRD_ECOLI sigcleave swissprot:EMRD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EMRD_ECOLI ## Database ID URL or Descriptions # BioGrid 4260740 48 # COFACTOR CAS3_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 21699496, ECO 0000269|PubMed 22521689}; # DISRUPTION PHENOTYPE Loss of plasmid silencing. {ECO:0000269|PubMed 18703739}. # DOMAIN CAS3_ECOLI Proteins of this family have an N-terminal nuclease domain and a C-terminal helicase/ATPase domain. In some CRISPR/Cas systems the domains are swapped, in others they are encoded separately. # EcoGene EG12634 ygcB # FUNCTION CAS3_ECOLI Acts as an endonuclease, a 3'-5'exonuclease, and an ATP- dependent dsDNA helicase. Anneals and unwinds R-loops (in which crRNA binds the target DNA, displacing the noncomplementary strand). Unwinding requires ATP, annealing does not. Required along with the Cascade complex for resistance to bacteriophage lambda infection as well as the ability to cure CRISPR-encoding high-copy number plasmid. A Cas3-CasA fusion protein purified with the Cascade complex nicks target plasmid in the presence but not absence of Mg(2+), and degrades plasmid fully in the presence of Mg(2+) and ATP, suggesting the helicase activity is required for complete degradation. # FUNCTION CAS3_ECOLI CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Cas3 plus Cascade participate in CRISPR interference, the third stage of CRISPR immunity. # GO_function GO:0000014 single-stranded DNA endodeoxyribonuclease activity; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; EXP:EcoCyc. # GO_function GO:0003690 double-stranded DNA binding; IDA:EcoCyc. # GO_function GO:0004004 ATP-dependent RNA helicase activity; IBA:GO_Central. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0008296 3'-5'-exodeoxyribonuclease activity; IDA:EcoCyc. # GO_function GO:0033680 ATP-dependent DNA/RNA helicase activity; IDA:EcoCyc. # GO_function GO:0097098 DNA/RNA hybrid annealing activity; IDA:EcoCyc. # GO_process GO:0000737 DNA catabolic process, endonucleolytic; IDA:EcoCyc. # GO_process GO:0000738 DNA catabolic process, exonucleolytic; IDA:EcoCyc. # GO_process GO:0010501 RNA secondary structure unwinding; IBA:GO_Central. # GO_process GO:0051607 defense response to virus; IDA:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004386 helicase activity # GOslim_function GO:0004518 nuclease activity # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0002376 immune system process # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # GOslim_process GO:0044403 symbiosis, encompassing mutualism through parasitism # Gene3D 3.40.50.300 -; 2. # IntAct P38036 7 # InterPro IPR001650 Helicase_C # InterPro IPR006474 Helicase_Cas3_CRISPR-ass_core # InterPro IPR006483 CRISPR-assoc_Cas3_HD # InterPro IPR011545 DEAD/DEAH_box_helicase_dom # InterPro IPR014001 Helicase_ATP-bd # InterPro IPR027417 P-loop_NTPase # Organism CAS3_ECOLI Escherichia coli (strain K12) # PATRIC 32120934 VBIEscCol129921_2859 # PIR E65057 E65057 # PROSITE PS51192 HELICASE_ATP_BIND_1 # PROSITE PS51194 HELICASE_CTER # PROSITE PS51643 HD_CAS3 # Pfam PF00270 DEAD # Pfam PF00271 Helicase_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CAS3_ECOLI CRISPR-associated endonuclease/helicase Cas3 # RefSeq NP_417241 NC_000913.3 # RefSeq WP_000433152 NZ_LN832404.1 # SIMILARITY Contains 1 HD Cas3-type domain. {ECO:0000255|PROSITE- ProRule PRU00974}. # SIMILARITY Contains 1 helicase ATP-binding domain. {ECO:0000255|PROSITE-ProRule PRU00541}. # SIMILARITY Contains 1 helicase C-terminal domain. {ECO:0000255|PROSITE-ProRule PRU00542}. # SIMILARITY In the N-terminal section; belongs to the CRISPR- associated nuclease Cas3-HD family. {ECO 0000305}. # SIMILARITY In the central section; belongs to the CRISPR- associated helicase Cas3 family. {ECO 0000305}. # SMART SM00487 DEXDc # SMART SM00490 HELICc # SUBUNIT Interacts with the CasA subunit of Cascade once Cascade has recognized target DNA. {ECO:0000269|PubMed 22521689}. # SUPFAM SSF52540 SSF52540; 3 # TIGRFAMs TIGR01587 cas3_core # TIGRFAMs TIGR01596 cas3_HD # eggNOG COG1203 LUCA # eggNOG ENOG4105DTT Bacteria BLAST swissprot:CAS3_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CAS3_ECOLI BioCyc ECOL316407:JW2731-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2731-MONOMER BioCyc EcoCyc:EG12634-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12634-MONOMER COG COG1203 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1203 DOI 10.1007/BF00269864 http://dx.doi.org/10.1007/BF00269864 DOI 10.1016/j.molcel.2012.03.018 http://dx.doi.org/10.1016/j.molcel.2012.03.018 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/BJ20110901 http://dx.doi.org/10.1042/BJ20110901 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1126/science.1159689 http://dx.doi.org/10.1126/science.1159689 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.-.- EC_number EC:3.6.4.- http://www.genome.jp/dbget-bin/www_bget?EC:3.6.4.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EMBL Y07525 http://www.ebi.ac.uk/ena/data/view/Y07525 ENZYME 3.1.-.- http://enzyme.expasy.org/EC/3.1.-.- ENZYME 3.6.4.- http://enzyme.expasy.org/EC/3.6.4.- EchoBASE EB2516 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2516 EcoGene EG12634 http://www.ecogene.org/geneInfo.php?eg_id=EG12634 EnsemblBacteria AAC75803 http://www.ensemblgenomes.org/id/AAC75803 EnsemblBacteria AAC75803 http://www.ensemblgenomes.org/id/AAC75803 EnsemblBacteria BAE76838 http://www.ensemblgenomes.org/id/BAE76838 EnsemblBacteria BAE76838 http://www.ensemblgenomes.org/id/BAE76838 EnsemblBacteria BAE76838 http://www.ensemblgenomes.org/id/BAE76838 EnsemblBacteria b2761 http://www.ensemblgenomes.org/id/b2761 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000014 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000014 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0003690 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003690 GO_function GO:0004004 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004004 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008296 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008296 GO_function GO:0033680 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033680 GO_function GO:0097098 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097098 GO_process GO:0000737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000737 GO_process GO:0000738 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000738 GO_process GO:0010501 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010501 GO_process GO:0051607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051607 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004386 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0002376 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 GOslim_process GO:0044403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947229 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947229 HOGENOM HOG000224183 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000224183&db=HOGENOM6 InParanoid P38036 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P38036 IntAct P38036 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P38036* IntEnz 3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1 IntEnz 3.6.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.4 InterPro IPR001650 http://www.ebi.ac.uk/interpro/entry/IPR001650 InterPro IPR006474 http://www.ebi.ac.uk/interpro/entry/IPR006474 InterPro IPR006483 http://www.ebi.ac.uk/interpro/entry/IPR006483 InterPro IPR011545 http://www.ebi.ac.uk/interpro/entry/IPR011545 InterPro IPR014001 http://www.ebi.ac.uk/interpro/entry/IPR014001 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Gene ecj:JW2731 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2731 KEGG_Gene eco:b2761 http://www.genome.jp/dbget-bin/www_bget?eco:b2761 KEGG_Orthology KO:K07012 http://www.genome.jp/dbget-bin/www_bget?KO:K07012 OMA CWIRNTV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CWIRNTV PROSITE PS51192 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51192 PROSITE PS51194 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51194 PROSITE PS51643 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51643 PSORT swissprot:CAS3_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CAS3_ECOLI PSORT-B swissprot:CAS3_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CAS3_ECOLI PSORT2 swissprot:CAS3_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CAS3_ECOLI Pfam PF00270 http://pfam.xfam.org/family/PF00270 Pfam PF00271 http://pfam.xfam.org/family/PF00271 Phobius swissprot:CAS3_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CAS3_ECOLI PhylomeDB P38036 http://phylomedb.org/?seqid=P38036 ProteinModelPortal P38036 http://www.proteinmodelportal.org/query/uniprot/P38036 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18703739 http://www.ncbi.nlm.nih.gov/pubmed/18703739 PubMed 2005873 http://www.ncbi.nlm.nih.gov/pubmed/2005873 PubMed 21699496 http://www.ncbi.nlm.nih.gov/pubmed/21699496 PubMed 22521689 http://www.ncbi.nlm.nih.gov/pubmed/22521689 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417241 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417241 RefSeq WP_000433152 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000433152 SMART SM00487 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00487 SMART SM00490 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00490 STRING 511145.b2761 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2761&targetmode=cogs STRING COG1203 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1203&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR01587 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01587 TIGRFAMs TIGR01596 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01596 UniProtKB CAS3_ECOLI http://www.uniprot.org/uniprot/CAS3_ECOLI UniProtKB-AC P38036 http://www.uniprot.org/uniprot/P38036 charge swissprot:CAS3_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CAS3_ECOLI eggNOG COG1203 http://eggnogapi.embl.de/nog_data/html/tree/COG1203 eggNOG ENOG4105DTT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DTT epestfind swissprot:CAS3_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CAS3_ECOLI garnier swissprot:CAS3_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CAS3_ECOLI helixturnhelix swissprot:CAS3_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CAS3_ECOLI hmoment swissprot:CAS3_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CAS3_ECOLI iep swissprot:CAS3_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CAS3_ECOLI inforesidue swissprot:CAS3_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CAS3_ECOLI octanol swissprot:CAS3_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CAS3_ECOLI pepcoil swissprot:CAS3_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CAS3_ECOLI pepdigest swissprot:CAS3_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CAS3_ECOLI pepinfo swissprot:CAS3_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CAS3_ECOLI pepnet swissprot:CAS3_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CAS3_ECOLI pepstats swissprot:CAS3_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CAS3_ECOLI pepwheel swissprot:CAS3_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CAS3_ECOLI pepwindow swissprot:CAS3_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CAS3_ECOLI sigcleave swissprot:CAS3_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CAS3_ECOLI ## Database ID URL or Descriptions # AltName NADC_ECOLI Quinolinate phosphoribosyltransferase [decarboxylating] # BRENDA 2.4.2.19 2026 # BioGrid 4263544 5 # CATALYTIC ACTIVITY NADC_ECOLI Beta-nicotinate D-ribonucleotide + diphosphate + CO(2) = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1- diphosphate. # EcoGene EG11546 nadC # FUNCTION NADC_ECOLI Involved in the catabolism of quinolinic acid (QA). {ECO 0000250}. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity; IDA:EcoCyc. # GO_process GO:0009435 NAD biosynthetic process; IDA:EcoliWiki. # GO_process GO:0034213 quinolinate catabolic process; IBA:GO_Central. # GO_process GO:0034628 'de novo' NAD biosynthetic process from aspartate; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.20.20.70 -; 1. # Gene3D 3.90.1170.20 -; 1. # IntAct P30011 3 # InterPro IPR002638 Quinolinate_PRibosylTrfase_C # InterPro IPR004393 NadC # InterPro IPR013785 Aldolase_TIM # InterPro IPR022412 Quinolinate_PRibosylTrfase_N # InterPro IPR027277 NadC/ModD # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00760 Nicotinate and nicotinamide metabolism # Organism NADC_ECOLI Escherichia coli (strain K12) # PATHWAY Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D- ribonucleotide from quinolinate step 1/1. # PATRIC 32115319 VBIEscCol129921_0111 # PIR E64733 E64733 # PIRSF PIRSF006250 NadC_ModD # Pfam PF01729 QRPTase_C # Pfam PF02749 QRPTase_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NADC_ECOLI Nicotinate-nucleotide pyrophosphorylase [carboxylating] # RefSeq NP_414651 NC_000913.3 # RefSeq WP_001135174 NZ_LN832404.1 # SIMILARITY Belongs to the NadC/ModD family. {ECO 0000305}. # SUBUNIT Homodimer Hexamer formed by 3 homodimers (By similarity). Homodimer. {ECO 0000250}. # SUPFAM SSF51690 SSF51690 # TIGRFAMs TIGR00078 nadC # UniPathway UPA00253 UER00331 # eggNOG COG0157 LUCA # eggNOG ENOG4105D18 Bacteria BLAST swissprot:NADC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NADC_ECOLI BioCyc ECOL316407:JW0105-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0105-MONOMER BioCyc EcoCyc:QUINOPRIBOTRANS-MONOMER http://biocyc.org/getid?id=EcoCyc:QUINOPRIBOTRANS-MONOMER BioCyc MetaCyc:QUINOPRIBOTRANS-MONOMER http://biocyc.org/getid?id=MetaCyc:QUINOPRIBOTRANS-MONOMER COG COG0157 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0157 DIP DIP-10293N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10293N DOI 10.1006/abbi.1996.0034 http://dx.doi.org/10.1006/abbi.1996.0034 DOI 10.1016/0378-1119(94)90851-6 http://dx.doi.org/10.1016/0378-1119(94)90851-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1111/j.1365-2958.1989.tb00259.x http://dx.doi.org/10.1111/j.1365-2958.1989.tb00259.x DOI 10.1111/j.1365-2958.1989.tb00262.x http://dx.doi.org/10.1111/j.1365-2958.1989.tb00262.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.4.2.19 http://www.genome.jp/dbget-bin/www_bget?EC:2.4.2.19 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L20833 http://www.ebi.ac.uk/ena/data/view/L20833 EMBL L28105 http://www.ebi.ac.uk/ena/data/view/L28105 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X15237 http://www.ebi.ac.uk/ena/data/view/X15237 ENZYME 2.4.2.19 http://enzyme.expasy.org/EC/2.4.2.19 EchoBASE EB1508 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1508 EcoGene EG11546 http://www.ecogene.org/geneInfo.php?eg_id=EG11546 EnsemblBacteria AAC73220 http://www.ensemblgenomes.org/id/AAC73220 EnsemblBacteria AAC73220 http://www.ensemblgenomes.org/id/AAC73220 EnsemblBacteria BAE76041 http://www.ensemblgenomes.org/id/BAE76041 EnsemblBacteria BAE76041 http://www.ensemblgenomes.org/id/BAE76041 EnsemblBacteria BAE76041 http://www.ensemblgenomes.org/id/BAE76041 EnsemblBacteria b0109 http://www.ensemblgenomes.org/id/b0109 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004514 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004514 GO_process GO:0009435 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009435 GO_process GO:0034213 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034213 GO_process GO:0034628 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034628 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 Gene3D 3.90.1170.20 http://www.cathdb.info/version/latest/superfamily/3.90.1170.20 GeneID 948869 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948869 HOGENOM HOG000224022 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000224022&db=HOGENOM6 InParanoid P30011 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30011 IntAct P30011 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P30011* IntEnz 2.4.2.19 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.2.19 InterPro IPR002638 http://www.ebi.ac.uk/interpro/entry/IPR002638 InterPro IPR004393 http://www.ebi.ac.uk/interpro/entry/IPR004393 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR022412 http://www.ebi.ac.uk/interpro/entry/IPR022412 InterPro IPR027277 http://www.ebi.ac.uk/interpro/entry/IPR027277 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0105 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0105 KEGG_Gene eco:b0109 http://www.genome.jp/dbget-bin/www_bget?eco:b0109 KEGG_Orthology KO:K00767 http://www.genome.jp/dbget-bin/www_bget?KO:K00767 KEGG_Pathway ko00760 http://www.genome.jp/kegg-bin/show_pathway?ko00760 KEGG_Reaction rn:R03348 http://www.genome.jp/dbget-bin/www_bget?rn:R03348 MINT MINT-1227037 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1227037 OMA DMIMLKD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DMIMLKD PSORT swissprot:NADC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NADC_ECOLI PSORT-B swissprot:NADC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NADC_ECOLI PSORT2 swissprot:NADC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NADC_ECOLI Pfam PF01729 http://pfam.xfam.org/family/PF01729 Pfam PF02749 http://pfam.xfam.org/family/PF02749 Phobius swissprot:NADC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NADC_ECOLI PhylomeDB P30011 http://phylomedb.org/?seqid=P30011 ProteinModelPortal P30011 http://www.proteinmodelportal.org/query/uniprot/P30011 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2607970 http://www.ncbi.nlm.nih.gov/pubmed/2607970 PubMed 2691840 http://www.ncbi.nlm.nih.gov/pubmed/2691840 PubMed 7959070 http://www.ncbi.nlm.nih.gov/pubmed/7959070 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 8419294 http://www.ncbi.nlm.nih.gov/pubmed/8419294 PubMed 8561507 http://www.ncbi.nlm.nih.gov/pubmed/8561507 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414651 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414651 RefSeq WP_001135174 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001135174 SMR P30011 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P30011 STRING 511145.b0109 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0109&targetmode=cogs STRING COG0157 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0157&targetmode=cogs SUPFAM SSF51690 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51690 TIGRFAMs TIGR00078 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00078 UniProtKB NADC_ECOLI http://www.uniprot.org/uniprot/NADC_ECOLI UniProtKB-AC P30011 http://www.uniprot.org/uniprot/P30011 charge swissprot:NADC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NADC_ECOLI eggNOG COG0157 http://eggnogapi.embl.de/nog_data/html/tree/COG0157 eggNOG ENOG4105D18 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D18 epestfind swissprot:NADC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NADC_ECOLI garnier swissprot:NADC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NADC_ECOLI helixturnhelix swissprot:NADC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NADC_ECOLI hmoment swissprot:NADC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NADC_ECOLI iep swissprot:NADC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NADC_ECOLI inforesidue swissprot:NADC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NADC_ECOLI octanol swissprot:NADC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NADC_ECOLI pepcoil swissprot:NADC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NADC_ECOLI pepdigest swissprot:NADC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NADC_ECOLI pepinfo swissprot:NADC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NADC_ECOLI pepnet swissprot:NADC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NADC_ECOLI pepstats swissprot:NADC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NADC_ECOLI pepwheel swissprot:NADC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NADC_ECOLI pepwindow swissprot:NADC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NADC_ECOLI sigcleave swissprot:NADC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NADC_ECOLI ## Database ID URL or Descriptions # BRENDA 5.3.1 2026 # CATALYTIC ACTIVITY ARAA_ECOLI L-arabinose = L-ribulose. # COFACTOR Name=Mn(2+); Xref=ChEBI:CHEBI 29035; Note=Binds 1 Mn(2+) ion per subunit.; # EcoGene EG10052 araA # FUNCTION ARAA_ECOLI Catalyzes the conversion of L-arabinose to L-ribulose. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008733 L-arabinose isomerase activity; IDA:EcoCyc. # GO_function GO:0030145 manganese ion binding; IEA:UniProtKB-HAMAP. # GO_process GO:0019568 arabinose catabolic process; IMP:EcoliWiki. # GO_process GO:0019569 L-arabinose catabolic process to xylulose 5-phosphate; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # HAMAP MF_00519 Arabinose_Isome # IntAct P08202 4 # InterPro IPR003762 Lara_isomerase # InterPro IPR004216 Fuc/Ara_isomerase_C # InterPro IPR009015 Fucose_isomerase_N/cen # InterPro IPR024664 Ara_Isoase_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00040 Pentose and glucuronate interconversions # Organism ARAA_ECOLI Escherichia coli (strain K12) # PATHWAY Carbohydrate degradation; L-arabinose degradation via L- ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route) step 1/3. # PATRIC 32115225 VBIEscCol129921_0064 # PDB 2AJT X-ray; 2.60 A; A/B/C=1-500 # PDB 2HXG X-ray; 2.80 A; A/B/C=1-500 # PDB 4F2D X-ray; 2.30 A; A/B/C=1-500 # PIR F64727 ISECAB # PIRSF PIRSF001478 L-ara_isomerase # Pfam PF02610 Arabinose_Isome # Pfam PF11762 Arabinose_Iso_C # ProDom PD018364 Lara_isomerase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ARAA_ECOLI L-arabinose isomerase # RefSeq NP_414604 NC_000913.3 # RefSeq WP_000151748 NZ_LN832404.1 # SIMILARITY Belongs to the arabinose isomerase family. {ECO 0000305}. # SUBUNIT Homohexamer. {ECO:0000269|PubMed 16756997, ECO:0000269|Ref.8}. # SUPFAM SSF50443 SSF50443 # SUPFAM SSF53743 SSF53743 # UniPathway UPA00145 UER00565 # eggNOG COG2160 LUCA # eggNOG ENOG4105CAC Bacteria BLAST swissprot:ARAA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARAA_ECOLI BioCyc ECOL316407:JW0061-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0061-MONOMER BioCyc EcoCyc:ARABISOM-MONOMER http://biocyc.org/getid?id=EcoCyc:ARABISOM-MONOMER BioCyc MetaCyc:ARABISOM-MONOMER http://biocyc.org/getid?id=MetaCyc:ARABISOM-MONOMER COG COG2160 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2160 DIP DIP-9123N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9123N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0378-1119(86)90067-3 http://dx.doi.org/10.1016/0378-1119(86)90067-3 DOI 10.1016/j.jmb.2006.04.040 http://dx.doi.org/10.1016/j.jmb.2006.04.040 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.3.1.4 http://www.genome.jp/dbget-bin/www_bget?EC:5.3.1.4 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M15263 http://www.ebi.ac.uk/ena/data/view/M15263 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X74279 http://www.ebi.ac.uk/ena/data/view/X74279 ENZYME 5.3.1.4 http://enzyme.expasy.org/EC/5.3.1.4 EchoBASE EB0050 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0050 EcoGene EG10052 http://www.ecogene.org/geneInfo.php?eg_id=EG10052 EnsemblBacteria AAC73173 http://www.ensemblgenomes.org/id/AAC73173 EnsemblBacteria AAC73173 http://www.ensemblgenomes.org/id/AAC73173 EnsemblBacteria BAB96631 http://www.ensemblgenomes.org/id/BAB96631 EnsemblBacteria BAB96631 http://www.ensemblgenomes.org/id/BAB96631 EnsemblBacteria BAB96631 http://www.ensemblgenomes.org/id/BAB96631 EnsemblBacteria b0062 http://www.ensemblgenomes.org/id/b0062 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008733 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008733 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_process GO:0019568 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019568 GO_process GO:0019569 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019569 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 947511 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947511 HAMAP MF_00519 http://hamap.expasy.org/unirule/MF_00519 HOGENOM HOG000252817 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000252817&db=HOGENOM6 InParanoid P08202 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P08202 IntAct P08202 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P08202* IntEnz 5.3.1.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.3.1.4 InterPro IPR003762 http://www.ebi.ac.uk/interpro/entry/IPR003762 InterPro IPR004216 http://www.ebi.ac.uk/interpro/entry/IPR004216 InterPro IPR009015 http://www.ebi.ac.uk/interpro/entry/IPR009015 InterPro IPR024664 http://www.ebi.ac.uk/interpro/entry/IPR024664 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0061 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0061 KEGG_Gene eco:b0062 http://www.genome.jp/dbget-bin/www_bget?eco:b0062 KEGG_Orthology KO:K01804 http://www.genome.jp/dbget-bin/www_bget?KO:K01804 KEGG_Pathway ko00040 http://www.genome.jp/kegg-bin/show_pathway?ko00040 KEGG_Reaction rn:R01761 http://www.genome.jp/dbget-bin/www_bget?rn:R01761 OMA LMEDYTY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LMEDYTY PDB 2AJT http://www.ebi.ac.uk/pdbe-srv/view/entry/2AJT PDB 2HXG http://www.ebi.ac.uk/pdbe-srv/view/entry/2HXG PDB 4F2D http://www.ebi.ac.uk/pdbe-srv/view/entry/4F2D PDBsum 2AJT http://www.ebi.ac.uk/pdbsum/2AJT PDBsum 2HXG http://www.ebi.ac.uk/pdbsum/2HXG PDBsum 4F2D http://www.ebi.ac.uk/pdbsum/4F2D PSORT swissprot:ARAA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARAA_ECOLI PSORT-B swissprot:ARAA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARAA_ECOLI PSORT2 swissprot:ARAA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARAA_ECOLI Pfam PF02610 http://pfam.xfam.org/family/PF02610 Pfam PF11762 http://pfam.xfam.org/family/PF11762 Phobius swissprot:ARAA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARAA_ECOLI PhylomeDB P08202 http://phylomedb.org/?seqid=P08202 ProteinModelPortal P08202 http://www.proteinmodelportal.org/query/uniprot/P08202 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16756997 http://www.ncbi.nlm.nih.gov/pubmed/16756997 PubMed 3549454 http://www.ncbi.nlm.nih.gov/pubmed/3549454 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_414604 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414604 RefSeq WP_000151748 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000151748 SMR P08202 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P08202 STRING 511145.b0062 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0062&targetmode=cogs STRING COG2160 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2160&targetmode=cogs SUPFAM SSF50443 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50443 SUPFAM SSF53743 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53743 UniProtKB ARAA_ECOLI http://www.uniprot.org/uniprot/ARAA_ECOLI UniProtKB-AC P08202 http://www.uniprot.org/uniprot/P08202 charge swissprot:ARAA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARAA_ECOLI eggNOG COG2160 http://eggnogapi.embl.de/nog_data/html/tree/COG2160 eggNOG ENOG4105CAC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CAC epestfind swissprot:ARAA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARAA_ECOLI garnier swissprot:ARAA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARAA_ECOLI helixturnhelix swissprot:ARAA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARAA_ECOLI hmoment swissprot:ARAA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARAA_ECOLI iep swissprot:ARAA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARAA_ECOLI inforesidue swissprot:ARAA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARAA_ECOLI octanol swissprot:ARAA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARAA_ECOLI pepcoil swissprot:ARAA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARAA_ECOLI pepdigest swissprot:ARAA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARAA_ECOLI pepinfo swissprot:ARAA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARAA_ECOLI pepnet swissprot:ARAA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARAA_ECOLI pepstats swissprot:ARAA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARAA_ECOLI pepwheel swissprot:ARAA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARAA_ECOLI pepwindow swissprot:ARAA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARAA_ECOLI sigcleave swissprot:ARAA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARAA_ECOLI ## Database ID URL or Descriptions # AltName AROK_ECOLI Shikimate kinase I # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=20 mM for shikimate {ECO 0000269|PubMed:3001029}; # BioGrid 4259297 192 # CATALYTIC ACTIVITY AROK_ECOLI ATP + shikimate = ADP + shikimate 3-phosphate. # CDD cd00464 SK # COFACTOR AROK_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000305}; Note=Binds 1 Mg(2+) ion per subunit. {ECO 0000305}; # DOMAIN AROK_ECOLI The LID domain closes over the active site upon ATP binding. # EcoGene EG10081 aroK # FUNCTION AROK_ECOLI Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. {ECO 0000269|PubMed 1309529}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IBA:GO_Central. # GO_function GO:0004765 shikimate kinase activity; IBA:GO_Central. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_process GO:0008652 cellular amino acid biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0009073 aromatic amino acid family biosynthetic process; IBA:GO_Central. # GO_process GO:0009423 chorismate biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0019632 shikimate metabolic process; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.300 -; 1. # HAMAP MF_00109 Shikimate_kinase # INDUCTION AROK_ECOLI Constitutively expressed. # InterPro IPR000623 Shikimate_kinase/TSH1 # InterPro IPR023000 Shikimate_kinase_CS # InterPro IPR027417 P-loop_NTPase # InterPro IPR031322 Shikimate/glucono_kinase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis # MISCELLANEOUS AROK_ECOLI Two isozymes have been found in E.coli. AroK has 100-fold lower affinity for shikimate than AroL, suggesting that AroL is the dominant enzyme in the biosynthesis of the aromatic amino acids, with AroK playing a secondary role and possibly participating in an as yet unidentified cellular process. # Organism AROK_ECOLI Escherichia coli (strain K12) # PATHWAY Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate step 5/7. # PATRIC 32122212 VBIEscCol129921_3483 # PDB 1KAG X-ray; 2.05 A; A/B=1-173 # PIR A65134 A65134 # PROSITE PS01128 SHIKIMATE_KINASE # Pfam PF01202 SKI # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AROK_ECOLI Shikimate kinase 1 # RefSeq WP_000818618 NZ_LN832404.1 # RefSeq YP_026215 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA58187.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAC36834.1; Type=Frameshift; Positions=98; Evidence={ECO 0000305}; Sequence=CAA79665.1; Type=Frameshift; Positions=98; Evidence={ECO:0000305}; # SIMILARITY Belongs to the shikimate kinase family. {ECO 0000305}. # SUBCELLULAR LOCATION AROK_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Monomer. {ECO:0000269|PubMed 12001235}. # SUPFAM SSF52540 SSF52540 # UniPathway UPA00053 UER00088 # eggNOG COG0703 LUCA # eggNOG ENOG4105KHV Bacteria BLAST swissprot:AROK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AROK_ECOLI BioCyc ECOL316407:JW5947-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5947-MONOMER BioCyc EcoCyc:AROK-MONOMER http://biocyc.org/getid?id=EcoCyc:AROK-MONOMER COG COG0703 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0703 DIP DIP-48271N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48271N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1002/prot.10099.abs http://dx.doi.org/10.1002/prot.10099.abs DOI 10.1006/jmbi.1998.1726 http://dx.doi.org/10.1006/jmbi.1998.1726 DOI 10.1007/BF00290345 http://dx.doi.org/10.1007/BF00290345 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1992.tb01356.x http://dx.doi.org/10.1111/j.1365-2958.1992.tb01356.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.71 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.71 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L39822 http://www.ebi.ac.uk/ena/data/view/L39822 EMBL M76389 http://www.ebi.ac.uk/ena/data/view/M76389 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X80167 http://www.ebi.ac.uk/ena/data/view/X80167 EMBL Z19601 http://www.ebi.ac.uk/ena/data/view/Z19601 ENZYME 2.7.1.71 http://enzyme.expasy.org/EC/2.7.1.71 EchoBASE EB0079 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0079 EcoGene EG10081 http://www.ecogene.org/geneInfo.php?eg_id=EG10081 EnsemblBacteria AAC76415 http://www.ensemblgenomes.org/id/AAC76415 EnsemblBacteria AAC76415 http://www.ensemblgenomes.org/id/AAC76415 EnsemblBacteria BAE77901 http://www.ensemblgenomes.org/id/BAE77901 EnsemblBacteria BAE77901 http://www.ensemblgenomes.org/id/BAE77901 EnsemblBacteria BAE77901 http://www.ensemblgenomes.org/id/BAE77901 EnsemblBacteria b3390 http://www.ensemblgenomes.org/id/b3390 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0004765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004765 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0008652 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008652 GO_process GO:0009073 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009073 GO_process GO:0009423 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009423 GO_process GO:0019632 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019632 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 2847759 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2847759 HAMAP MF_00109 http://hamap.expasy.org/unirule/MF_00109 HOGENOM HOG000032568 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000032568&db=HOGENOM6 InParanoid P0A6D7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6D7 IntAct P0A6D7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6D7* IntEnz 2.7.1.71 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.71 InterPro IPR000623 http://www.ebi.ac.uk/interpro/entry/IPR000623 InterPro IPR023000 http://www.ebi.ac.uk/interpro/entry/IPR023000 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR031322 http://www.ebi.ac.uk/interpro/entry/IPR031322 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5947 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5947 KEGG_Gene eco:b3390 http://www.genome.jp/dbget-bin/www_bget?eco:b3390 KEGG_Orthology KO:K00891 http://www.genome.jp/dbget-bin/www_bget?KO:K00891 KEGG_Pathway ko00400 http://www.genome.jp/kegg-bin/show_pathway?ko00400 KEGG_Reaction rn:R02412 http://www.genome.jp/dbget-bin/www_bget?rn:R02412 MINT MINT-1299909 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1299909 OMA FEQHGEA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FEQHGEA PDB 1KAG http://www.ebi.ac.uk/pdbe-srv/view/entry/1KAG PDBsum 1KAG http://www.ebi.ac.uk/pdbsum/1KAG PROSITE PS01128 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01128 PSORT swissprot:AROK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AROK_ECOLI PSORT-B swissprot:AROK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AROK_ECOLI PSORT2 swissprot:AROK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AROK_ECOLI Pfam PF01202 http://pfam.xfam.org/family/PF01202 Phobius swissprot:AROK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AROK_ECOLI PhylomeDB P0A6D7 http://phylomedb.org/?seqid=P0A6D7 ProteinModelPortal P0A6D7 http://www.proteinmodelportal.org/query/uniprot/P0A6D7 PubMed 12001235 http://www.ncbi.nlm.nih.gov/pubmed/12001235 PubMed 1309529 http://www.ncbi.nlm.nih.gov/pubmed/1309529 PubMed 1630320 http://www.ncbi.nlm.nih.gov/pubmed/1630320 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3001029 http://www.ncbi.nlm.nih.gov/pubmed/3001029 PubMed 7603433 http://www.ncbi.nlm.nih.gov/pubmed/7603433 PubMed 7612934 http://www.ncbi.nlm.nih.gov/pubmed/7612934 PubMed 7883721 http://www.ncbi.nlm.nih.gov/pubmed/7883721 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 RefSeq WP_000818618 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000818618 RefSeq YP_026215 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026215 SMR P0A6D7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6D7 STRING 511145.b3390 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3390&targetmode=cogs STRING COG0703 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0703&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SWISS-2DPAGE P0A6D7 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A6D7 UniProtKB AROK_ECOLI http://www.uniprot.org/uniprot/AROK_ECOLI UniProtKB-AC P0A6D7 http://www.uniprot.org/uniprot/P0A6D7 charge swissprot:AROK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AROK_ECOLI eggNOG COG0703 http://eggnogapi.embl.de/nog_data/html/tree/COG0703 eggNOG ENOG4105KHV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KHV epestfind swissprot:AROK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AROK_ECOLI garnier swissprot:AROK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AROK_ECOLI helixturnhelix swissprot:AROK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AROK_ECOLI hmoment swissprot:AROK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AROK_ECOLI iep swissprot:AROK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AROK_ECOLI inforesidue swissprot:AROK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AROK_ECOLI octanol swissprot:AROK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AROK_ECOLI pepcoil swissprot:AROK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AROK_ECOLI pepdigest swissprot:AROK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AROK_ECOLI pepinfo swissprot:AROK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AROK_ECOLI pepnet swissprot:AROK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AROK_ECOLI pepstats swissprot:AROK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AROK_ECOLI pepwheel swissprot:AROK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AROK_ECOLI pepwindow swissprot:AROK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AROK_ECOLI sigcleave swissprot:AROK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AROK_ECOLI ## Database ID URL or Descriptions # BioGrid 4262579 2 # EcoGene EG11697 yidI # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR016512 Uncharacterised_IM_YidI # Organism YIDI_ECOLI Escherichia coli (strain K12) # PATRIC 32122845 VBIEscCol129921_3798 # PIR F65169 F65169 # PIRSF PIRSF007312 Inner_membrane_protein_YidI # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIDI_ECOLI Inner membrane protein YidI # RefSeq NP_418133 NC_000913.3 # RefSeq WP_000511289 NZ_LN832404.1 # SUBCELLULAR LOCATION YIDI_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG ENOG4106DRA Bacteria # eggNOG ENOG411212H LUCA BLAST swissprot:YIDI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIDI_ECOLI BioCyc ECOL316407:JW3653-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3653-MONOMER BioCyc EcoCyc:EG11697-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11697-MONOMER DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1648 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1648 EcoGene EG11697 http://www.ecogene.org/geneInfo.php?eg_id=EG11697 EnsemblBacteria AAC76700 http://www.ensemblgenomes.org/id/AAC76700 EnsemblBacteria AAC76700 http://www.ensemblgenomes.org/id/AAC76700 EnsemblBacteria BAE77616 http://www.ensemblgenomes.org/id/BAE77616 EnsemblBacteria BAE77616 http://www.ensemblgenomes.org/id/BAE77616 EnsemblBacteria BAE77616 http://www.ensemblgenomes.org/id/BAE77616 EnsemblBacteria b3677 http://www.ensemblgenomes.org/id/b3677 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 948189 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948189 HOGENOM HOG000009640 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009640&db=HOGENOM6 InParanoid P31446 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31446 InterPro IPR016512 http://www.ebi.ac.uk/interpro/entry/IPR016512 KEGG_Gene ecj:JW3653 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3653 KEGG_Gene eco:b3677 http://www.genome.jp/dbget-bin/www_bget?eco:b3677 OMA PLMLEST http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PLMLEST PSORT swissprot:YIDI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIDI_ECOLI PSORT-B swissprot:YIDI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIDI_ECOLI PSORT2 swissprot:YIDI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIDI_ECOLI Phobius swissprot:YIDI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIDI_ECOLI ProteinModelPortal P31446 http://www.proteinmodelportal.org/query/uniprot/P31446 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418133 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418133 RefSeq WP_000511289 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000511289 STRING 511145.b3677 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3677&targetmode=cogs UniProtKB YIDI_ECOLI http://www.uniprot.org/uniprot/YIDI_ECOLI UniProtKB-AC P31446 http://www.uniprot.org/uniprot/P31446 charge swissprot:YIDI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIDI_ECOLI eggNOG ENOG4106DRA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106DRA eggNOG ENOG411212H http://eggnogapi.embl.de/nog_data/html/tree/ENOG411212H epestfind swissprot:YIDI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIDI_ECOLI garnier swissprot:YIDI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIDI_ECOLI helixturnhelix swissprot:YIDI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIDI_ECOLI hmoment swissprot:YIDI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIDI_ECOLI iep swissprot:YIDI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIDI_ECOLI inforesidue swissprot:YIDI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIDI_ECOLI octanol swissprot:YIDI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIDI_ECOLI pepcoil swissprot:YIDI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIDI_ECOLI pepdigest swissprot:YIDI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIDI_ECOLI pepinfo swissprot:YIDI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIDI_ECOLI pepnet swissprot:YIDI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIDI_ECOLI pepstats swissprot:YIDI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIDI_ECOLI pepwheel swissprot:YIDI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIDI_ECOLI pepwindow swissprot:YIDI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIDI_ECOLI sigcleave swissprot:YIDI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIDI_ECOLI ## Database ID URL or Descriptions # AltName TFAD_ECOLI Putative tail fiber assembly protein homolog from lambdoid prophage DLP12 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG13640 tfaD # InterPro IPR003458 Phage_T4_Gp38_tail_assem # InterPro IPR008866 Phage_lambda_GpA # MISCELLANEOUS TFAD_ECOLI Encoded by the cryptic lambdoid prophage DLP12. # Organism TFAD_ECOLI Escherichia coli (strain K12) # PIR G64788 G64788 # Pfam PF02413 Caudo_TAP # Pfam PF05876 Terminase_GpA # Proteomes UP000000625 Chromosome # RecName Putative protein TfaD {ECO 0000305} # RefSeq WP_001027248 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40757.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY In the C-terminal section; belongs to the tfa family. {ECO 0000305}. # eggNOG ENOG4105UZW Bacteria # eggNOG ENOG4111ZCI LUCA BLAST swissprot:TFAD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TFAD_ECOLI BioCyc EcoCyc:G6315-MONOMER http://biocyc.org/getid?id=EcoCyc:G6315-MONOMER DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB3404 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3404 EcoGene EG13640 http://www.ecogene.org/geneInfo.php?eg_id=EG13640 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv HOGENOM HOG000118670 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118670&db=HOGENOM6 InterPro IPR003458 http://www.ebi.ac.uk/interpro/entry/IPR003458 InterPro IPR008866 http://www.ebi.ac.uk/interpro/entry/IPR008866 PSORT swissprot:TFAD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TFAD_ECOLI PSORT-B swissprot:TFAD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TFAD_ECOLI PSORT2 swissprot:TFAD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TFAD_ECOLI Pfam PF02413 http://pfam.xfam.org/family/PF02413 Pfam PF05876 http://pfam.xfam.org/family/PF05876 Phobius swissprot:TFAD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TFAD_ECOLI PhylomeDB P77699 http://phylomedb.org/?seqid=P77699 ProteinModelPortal P77699 http://www.proteinmodelportal.org/query/uniprot/P77699 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001027248 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001027248 STRING 511145.b1546 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1546&targetmode=cogs UniProtKB TFAD_ECOLI http://www.uniprot.org/uniprot/TFAD_ECOLI UniProtKB-AC P77699 http://www.uniprot.org/uniprot/P77699 charge swissprot:TFAD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TFAD_ECOLI eggNOG ENOG4105UZW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105UZW eggNOG ENOG4111ZCI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111ZCI epestfind swissprot:TFAD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TFAD_ECOLI garnier swissprot:TFAD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TFAD_ECOLI helixturnhelix swissprot:TFAD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TFAD_ECOLI hmoment swissprot:TFAD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TFAD_ECOLI iep swissprot:TFAD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TFAD_ECOLI inforesidue swissprot:TFAD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TFAD_ECOLI octanol swissprot:TFAD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TFAD_ECOLI pepcoil swissprot:TFAD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TFAD_ECOLI pepdigest swissprot:TFAD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TFAD_ECOLI pepinfo swissprot:TFAD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TFAD_ECOLI pepnet swissprot:TFAD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TFAD_ECOLI pepstats swissprot:TFAD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TFAD_ECOLI pepwheel swissprot:TFAD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TFAD_ECOLI pepwindow swissprot:TFAD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TFAD_ECOLI sigcleave swissprot:TFAD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TFAD_ECOLI ## Database ID URL or Descriptions # EcoGene EG14489 yqfG # INDUCTION In stationary phase (at protein level). {ECO:0000269|PubMed 19121005}. # Organism YQFG_ECOLI Escherichia coli (strain K12) # PATRIC 32121186 VBIEscCol129921_2981 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQFG_ECOLI Uncharacterized protein YqfG # RefSeq WP_001010156 NZ_LN832404.1 # RefSeq YP_002791254 NC_000913.3 BLAST swissprot:YQFG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQFG_ECOLI BioCyc EcoCyc:MONOMER0-2883 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2883 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2008.06495.x http://dx.doi.org/10.1111/j.1365-2958.2008.06495.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14489 http://www.ecogene.org/geneInfo.php?eg_id=EG14489 EnsemblBacteria ACO60006 http://www.ensemblgenomes.org/id/ACO60006 EnsemblBacteria ACO60006 http://www.ensemblgenomes.org/id/ACO60006 EnsemblBacteria b4684 http://www.ensemblgenomes.org/id/b4684 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 7751638 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7751638 KEGG_Gene eco:b4684 http://www.genome.jp/dbget-bin/www_bget?eco:b4684 PSORT swissprot:YQFG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQFG_ECOLI PSORT-B swissprot:YQFG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQFG_ECOLI PSORT2 swissprot:YQFG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQFG_ECOLI Phobius swissprot:YQFG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQFG_ECOLI PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19121005 http://www.ncbi.nlm.nih.gov/pubmed/19121005 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001010156 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001010156 RefSeq YP_002791254 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_002791254 STRING 511145.b4684 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4684&targetmode=cogs UniProtKB YQFG_ECOLI http://www.uniprot.org/uniprot/YQFG_ECOLI UniProtKB-AC C1P614 http://www.uniprot.org/uniprot/C1P614 charge swissprot:YQFG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQFG_ECOLI epestfind swissprot:YQFG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQFG_ECOLI garnier swissprot:YQFG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQFG_ECOLI helixturnhelix swissprot:YQFG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQFG_ECOLI hmoment swissprot:YQFG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQFG_ECOLI iep swissprot:YQFG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQFG_ECOLI inforesidue swissprot:YQFG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQFG_ECOLI octanol swissprot:YQFG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQFG_ECOLI pepcoil swissprot:YQFG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQFG_ECOLI pepdigest swissprot:YQFG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQFG_ECOLI pepinfo swissprot:YQFG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQFG_ECOLI pepnet swissprot:YQFG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQFG_ECOLI pepstats swissprot:YQFG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQFG_ECOLI pepwheel swissprot:YQFG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQFG_ECOLI pepwindow swissprot:YQFG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQFG_ECOLI sigcleave swissprot:YQFG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQFG_ECOLI ## Database ID URL or Descriptions # BioGrid 4260130 22 # DISRUPTION PHENOTYPE Disruption mutant shows accumulation of a few incomplete LPS precursors. {ECO:0000269|PubMed 24722986}. # EcoGene EG13904 yciS # FUNCTION LAPA_ECOLI Involved in the assembly of lipopolysaccharide (LPS). {ECO 0000255|HAMAP-Rule MF_01948, ECO 0000269|PubMed 24722986}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_process GO:0008653 lipopolysaccharide metabolic process; IPI:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # HAMAP MF_01948 LPS_assembly_LapA # INDUCTION Induced by heat shock, via RpoH. {ECO:0000269|PubMed 24722986}. # InterPro IPR010445 LapA_dom # InterPro IPR032906 LapA # Organism LAPA_ECOLI Escherichia coli (strain K12) # PATRIC 32117820 VBIEscCol129921_1330 # PIR B64876 B64876 # Pfam PF06305 DUF1049 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LAPA_ECOLI Lipopolysaccharide assembly protein A {ECO 0000255|HAMAP-Rule MF_01948, ECO 0000303|PubMed 24722986} # RefSeq NP_415795 NC_000913.3 # RefSeq WP_000876286 NZ_LN832404.1 # SIMILARITY Belongs to the LapA family. {ECO:0000255|HAMAP- Rule MF_01948, ECO:0000305}. # SUBCELLULAR LOCATION LAPA_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01948, ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 24722986}; Multi-pass membrane protein {ECO 0000255|HAMAP-Rule MF_01948}. Note=Copurifies with LptE/LptD, LptBFGC, LptA, DnaK/DnaJ and LPS. {ECO 0000269|PubMed 24722986}. # eggNOG COG3771 LUCA # eggNOG ENOG4105Q4A Bacteria BLAST swissprot:LAPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LAPA_ECOLI BioCyc ECOL316407:JW1271-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1271-MONOMER BioCyc EcoCyc:G6637-MONOMER http://biocyc.org/getid?id=EcoCyc:G6637-MONOMER COG COG3771 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3771 DIP DIP-47880N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47880N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M113.539494 http://dx.doi.org/10.1074/jbc.M113.539494 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3663 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3663 EcoGene EG13904 http://www.ecogene.org/geneInfo.php?eg_id=EG13904 EnsemblBacteria AAC74361 http://www.ensemblgenomes.org/id/AAC74361 EnsemblBacteria AAC74361 http://www.ensemblgenomes.org/id/AAC74361 EnsemblBacteria BAA14833 http://www.ensemblgenomes.org/id/BAA14833 EnsemblBacteria BAA14833 http://www.ensemblgenomes.org/id/BAA14833 EnsemblBacteria BAA14833 http://www.ensemblgenomes.org/id/BAA14833 EnsemblBacteria b1279 http://www.ensemblgenomes.org/id/b1279 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_process GO:0008653 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008653 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GeneID 944936 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944936 HAMAP MF_01948 http://hamap.expasy.org/unirule/MF_01948 HOGENOM HOG000276312 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276312&db=HOGENOM6 InterPro IPR010445 http://www.ebi.ac.uk/interpro/entry/IPR010445 InterPro IPR032906 http://www.ebi.ac.uk/interpro/entry/IPR032906 KEGG_Gene ecj:JW1271 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1271 KEGG_Gene eco:b1279 http://www.genome.jp/dbget-bin/www_bget?eco:b1279 KEGG_Orthology KO:K08992 http://www.genome.jp/dbget-bin/www_bget?KO:K08992 OMA QGDYRIS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QGDYRIS PSORT swissprot:LAPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LAPA_ECOLI PSORT-B swissprot:LAPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LAPA_ECOLI PSORT2 swissprot:LAPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LAPA_ECOLI Pfam PF06305 http://pfam.xfam.org/family/PF06305 Phobius swissprot:LAPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LAPA_ECOLI ProteinModelPortal P0ACV4 http://www.proteinmodelportal.org/query/uniprot/P0ACV4 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 24722986 http://www.ncbi.nlm.nih.gov/pubmed/24722986 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415795 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415795 RefSeq WP_000876286 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000876286 STRING 511145.b1279 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1279&targetmode=cogs STRING COG3771 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3771&targetmode=cogs UniProtKB LAPA_ECOLI http://www.uniprot.org/uniprot/LAPA_ECOLI UniProtKB-AC P0ACV4 http://www.uniprot.org/uniprot/P0ACV4 charge swissprot:LAPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LAPA_ECOLI eggNOG COG3771 http://eggnogapi.embl.de/nog_data/html/tree/COG3771 eggNOG ENOG4105Q4A http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105Q4A epestfind swissprot:LAPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LAPA_ECOLI garnier swissprot:LAPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LAPA_ECOLI helixturnhelix swissprot:LAPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LAPA_ECOLI hmoment swissprot:LAPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LAPA_ECOLI iep swissprot:LAPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LAPA_ECOLI inforesidue swissprot:LAPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LAPA_ECOLI octanol swissprot:LAPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LAPA_ECOLI pepcoil swissprot:LAPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LAPA_ECOLI pepdigest swissprot:LAPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LAPA_ECOLI pepinfo swissprot:LAPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LAPA_ECOLI pepnet swissprot:LAPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LAPA_ECOLI pepstats swissprot:LAPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LAPA_ECOLI pepwheel swissprot:LAPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LAPA_ECOLI pepwindow swissprot:LAPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LAPA_ECOLI sigcleave swissprot:LAPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LAPA_ECOLI ## Database ID URL or Descriptions # BioGrid 4263393 383 # EcoGene EG12822 aaeB # FUNCTION AAEB_ECOLI Forms an efflux pump with AaeA. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell. Substrates are p- hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2- hydroxycinnamate. {ECO 0000255|HAMAP-Rule MF_01545, ECO 0000269|PubMed 15489430}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006810 transport; IMP:EcoliWiki. # GO_process GO:0046942 carboxylic acid transport; IMP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006810 transport # HAMAP MF_01545 AaeB # INDUCTION AAEB_ECOLI Positively coregulated with aaeA and aaeX by AaeR. {ECO 0000255|HAMAP-Rule MF_01545, ECO 0000269|PubMed 15489430}. # IntAct P46481 2 # InterPro IPR006726 PHBA_efflux_AaeB/fusaric-R # InterPro IPR023706 PHBA_efflux_pump_AaeB # KEGG_Brite ko02000 Transporters # Organism AAEB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30509:SF10 PTHR30509:SF10; 2 # PATRIC 32121906 VBIEscCol129921_3337 # PIR B65116 B65116 # Pfam PF04632 FUSC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName p-hydroxybenzoic acid efflux pump subunit AaeB {ECO:0000255|HAMAP-Rule MF_01545} # RefSeq NP_417707 NC_000913.3 # SIMILARITY Belongs to the aromatic acid exporter ArAE (TC 2.A.85) family. {ECO:0000255|HAMAP-Rule MF_01545}. # SUBCELLULAR LOCATION AAEB_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.85.1 the aromatic acid exporter (arae) family # eggNOG COG1289 LUCA # eggNOG ENOG4107Z11 Bacteria BLAST swissprot:AAEB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AAEB_ECOLI BioCyc ECOL316407:JW3209-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3209-MONOMER BioCyc EcoCyc:G7685-MONOMER http://biocyc.org/getid?id=EcoCyc:G7685-MONOMER BioCyc MetaCyc:G7685-MONOMER http://biocyc.org/getid?id=MetaCyc:G7685-MONOMER COG COG1289 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1289 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.186.21.7196-7204.2004 http://dx.doi.org/10.1128/JB.186.21.7196-7204.2004 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2673 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2673 EcoGene EG12822 http://www.ecogene.org/geneInfo.php?eg_id=EG12822 EnsemblBacteria AAC76272 http://www.ensemblgenomes.org/id/AAC76272 EnsemblBacteria AAC76272 http://www.ensemblgenomes.org/id/AAC76272 EnsemblBacteria BAE77283 http://www.ensemblgenomes.org/id/BAE77283 EnsemblBacteria BAE77283 http://www.ensemblgenomes.org/id/BAE77283 EnsemblBacteria BAE77283 http://www.ensemblgenomes.org/id/BAE77283 EnsemblBacteria b3240 http://www.ensemblgenomes.org/id/b3240 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GO_process GO:0046942 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046942 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 947747 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947747 HAMAP MF_01545 http://hamap.expasy.org/unirule/MF_01545 HOGENOM HOG000268026 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000268026&db=HOGENOM6 InParanoid P46481 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P46481 IntAct P46481 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P46481* InterPro IPR006726 http://www.ebi.ac.uk/interpro/entry/IPR006726 InterPro IPR023706 http://www.ebi.ac.uk/interpro/entry/IPR023706 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3209 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3209 KEGG_Gene eco:b3240 http://www.genome.jp/dbget-bin/www_bget?eco:b3240 KEGG_Orthology KO:K03468 http://www.genome.jp/dbget-bin/www_bget?KO:K03468 OMA MMAKDFL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MMAKDFL PANTHER PTHR30509:SF10 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30509:SF10 PSORT swissprot:AAEB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AAEB_ECOLI PSORT-B swissprot:AAEB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AAEB_ECOLI PSORT2 swissprot:AAEB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AAEB_ECOLI Pfam PF04632 http://pfam.xfam.org/family/PF04632 Phobius swissprot:AAEB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AAEB_ECOLI PhylomeDB P46481 http://phylomedb.org/?seqid=P46481 ProteinModelPortal P46481 http://www.proteinmodelportal.org/query/uniprot/P46481 PubMed 15489430 http://www.ncbi.nlm.nih.gov/pubmed/15489430 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417707 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417707 STRING 511145.b3240 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3240&targetmode=cogs STRING COG1289 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1289&targetmode=cogs TCDB 2.A.85.1 http://www.tcdb.org/search/result.php?tc=2.A.85.1 UniProtKB AAEB_ECOLI http://www.uniprot.org/uniprot/AAEB_ECOLI UniProtKB-AC P46481 http://www.uniprot.org/uniprot/P46481 charge swissprot:AAEB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AAEB_ECOLI eggNOG COG1289 http://eggnogapi.embl.de/nog_data/html/tree/COG1289 eggNOG ENOG4107Z11 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107Z11 epestfind swissprot:AAEB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AAEB_ECOLI garnier swissprot:AAEB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AAEB_ECOLI helixturnhelix swissprot:AAEB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AAEB_ECOLI hmoment swissprot:AAEB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AAEB_ECOLI iep swissprot:AAEB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AAEB_ECOLI inforesidue swissprot:AAEB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AAEB_ECOLI octanol swissprot:AAEB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AAEB_ECOLI pepcoil swissprot:AAEB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AAEB_ECOLI pepdigest swissprot:AAEB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AAEB_ECOLI pepinfo swissprot:AAEB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AAEB_ECOLI pepnet swissprot:AAEB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AAEB_ECOLI pepstats swissprot:AAEB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AAEB_ECOLI pepwheel swissprot:AAEB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AAEB_ECOLI pepwindow swissprot:AAEB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AAEB_ECOLI sigcleave swissprot:AAEB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AAEB_ECOLI ## Database ID URL or Descriptions # BioGrid 4262144 8 # EcoGene EG11267 yiaB # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoliWiki. # GO_process GO:0006974 cellular response to DNA damage stimulus; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006950 response to stress # InterPro IPR008024 YiaAB # Organism YIAB_ECOLI Escherichia coli (strain K12) # PATRIC 32122602 VBIEscCol129921_3678 # PIR S47784 Q3ECX1 # Pfam PF05360 YiaAB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIAB_ECOLI Inner membrane protein YiaB # RefSeq NP_418020 NC_000913.3 # RefSeq WP_001295228 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18540.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA28396.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SUBCELLULAR LOCATION YIAB_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 9.B.44.1 the yiaa-yiab (yiaab) family # eggNOG COG4682 LUCA # eggNOG ENOG410688U Bacteria BLAST swissprot:YIAB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIAB_ECOLI BioCyc ECOL316407:JW5654-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5654-MONOMER BioCyc EcoCyc:EG11267-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11267-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.052018199 http://dx.doi.org/10.1073/pnas.052018199 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X04691 http://www.ebi.ac.uk/ena/data/view/X04691 EchoBASE EB1246 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1246 EcoGene EG11267 http://www.ecogene.org/geneInfo.php?eg_id=EG11267 EnsemblBacteria AAC76587 http://www.ensemblgenomes.org/id/AAC76587 EnsemblBacteria AAC76587 http://www.ensemblgenomes.org/id/AAC76587 EnsemblBacteria BAE77730 http://www.ensemblgenomes.org/id/BAE77730 EnsemblBacteria BAE77730 http://www.ensemblgenomes.org/id/BAE77730 EnsemblBacteria BAE77730 http://www.ensemblgenomes.org/id/BAE77730 EnsemblBacteria b3563 http://www.ensemblgenomes.org/id/b3563 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 948152 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948152 HOGENOM HOG000126047 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126047&db=HOGENOM6 InterPro IPR008024 http://www.ebi.ac.uk/interpro/entry/IPR008024 KEGG_Gene ecj:JW5654 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5654 KEGG_Gene eco:b3563 http://www.genome.jp/dbget-bin/www_bget?eco:b3563 OMA WREKSIY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WREKSIY PSORT swissprot:YIAB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIAB_ECOLI PSORT-B swissprot:YIAB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIAB_ECOLI PSORT2 swissprot:YIAB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIAB_ECOLI Pfam PF05360 http://pfam.xfam.org/family/PF05360 Phobius swissprot:YIAB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIAB_ECOLI ProteinModelPortal P11286 http://www.proteinmodelportal.org/query/uniprot/P11286 PubMed 11867724 http://www.ncbi.nlm.nih.gov/pubmed/11867724 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6320721 http://www.ncbi.nlm.nih.gov/pubmed/6320721 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418020 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418020 RefSeq WP_001295228 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295228 STRING 511145.b3563 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3563&targetmode=cogs TCDB 9.B.44.1 http://www.tcdb.org/search/result.php?tc=9.B.44.1 UniProtKB YIAB_ECOLI http://www.uniprot.org/uniprot/YIAB_ECOLI UniProtKB-AC P11286 http://www.uniprot.org/uniprot/P11286 charge swissprot:YIAB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIAB_ECOLI eggNOG COG4682 http://eggnogapi.embl.de/nog_data/html/tree/COG4682 eggNOG ENOG410688U http://eggnogapi.embl.de/nog_data/html/tree/ENOG410688U epestfind swissprot:YIAB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIAB_ECOLI garnier swissprot:YIAB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIAB_ECOLI helixturnhelix swissprot:YIAB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIAB_ECOLI hmoment swissprot:YIAB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIAB_ECOLI iep swissprot:YIAB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIAB_ECOLI inforesidue swissprot:YIAB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIAB_ECOLI octanol swissprot:YIAB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIAB_ECOLI pepcoil swissprot:YIAB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIAB_ECOLI pepdigest swissprot:YIAB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIAB_ECOLI pepinfo swissprot:YIAB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIAB_ECOLI pepnet swissprot:YIAB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIAB_ECOLI pepstats swissprot:YIAB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIAB_ECOLI pepwheel swissprot:YIAB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIAB_ECOLI pepwindow swissprot:YIAB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIAB_ECOLI sigcleave swissprot:YIAB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIAB_ECOLI ## Database ID URL or Descriptions # BioGrid 4262986 8 # EcoGene EG13724 hspQ # FUNCTION HSPQ_ECOLI Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_process GO:0009408 response to heat; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006950 response to stress # HAMAP MF_01194 HspQ # INDUCTION By heat shock. Transcribed by the sigma-32 subunit of RNA polymerase. {ECO:0000269|PubMed 15569148}. # InterPro IPR011722 Hemimethylated_DNA-bd_dom # InterPro IPR022866 HspQ # Organism HSPQ_ECOLI Escherichia coli (strain K12) # PATRIC 32117153 VBIEscCol129921_1001 # PDB 1VBV X-ray; 2.70 A; A=1-105 # PIR E64837 E64837 # Pfam PF08755 YccV-like # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HSPQ_ECOLI Heat shock protein HspQ # RefSeq NP_415486 NC_000913.3 # RefSeq WP_001295356 NZ_LN832404.1 # SIMILARITY Belongs to the HspQ family. {ECO 0000305}. # SMART SM00992 YccV-like # SUBCELLULAR LOCATION HSPQ_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF141255 SSF141255 # TIGRFAMs TIGR02097 yccV # eggNOG COG3785 LUCA # eggNOG ENOG4105GSS Bacteria BLAST swissprot:HSPQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HSPQ_ECOLI BioCyc ECOL316407:JW5970-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5970-MONOMER BioCyc EcoCyc:G6500-MONOMER http://biocyc.org/getid?id=EcoCyc:G6500-MONOMER COG COG3785 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3785 DIP DIP-48155N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48155N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2443.2004.00800.x http://dx.doi.org/10.1111/j.1365-2443.2004.00800.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3488 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3488 EcoGene EG13724 http://www.ecogene.org/geneInfo.php?eg_id=EG13724 EnsemblBacteria AAC74052 http://www.ensemblgenomes.org/id/AAC74052 EnsemblBacteria AAC74052 http://www.ensemblgenomes.org/id/AAC74052 EnsemblBacteria BAA35731 http://www.ensemblgenomes.org/id/BAA35731 EnsemblBacteria BAA35731 http://www.ensemblgenomes.org/id/BAA35731 EnsemblBacteria BAA35731 http://www.ensemblgenomes.org/id/BAA35731 EnsemblBacteria b0966 http://www.ensemblgenomes.org/id/b0966 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 945578 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945578 HAMAP MF_01194 http://hamap.expasy.org/unirule/MF_01194 HOGENOM HOG000139612 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000139612&db=HOGENOM6 InParanoid P0AB20 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AB20 InterPro IPR011722 http://www.ebi.ac.uk/interpro/entry/IPR011722 InterPro IPR022866 http://www.ebi.ac.uk/interpro/entry/IPR022866 KEGG_Gene ecj:JW5970 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5970 KEGG_Gene eco:b0966 http://www.genome.jp/dbget-bin/www_bget?eco:b0966 KEGG_Orthology KO:K11940 http://www.genome.jp/dbget-bin/www_bget?KO:K11940 OMA LRTAPWY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LRTAPWY PDB 1VBV http://www.ebi.ac.uk/pdbe-srv/view/entry/1VBV PDBsum 1VBV http://www.ebi.ac.uk/pdbsum/1VBV PSORT swissprot:HSPQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HSPQ_ECOLI PSORT-B swissprot:HSPQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HSPQ_ECOLI PSORT2 swissprot:HSPQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HSPQ_ECOLI Pfam PF08755 http://pfam.xfam.org/family/PF08755 Phobius swissprot:HSPQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HSPQ_ECOLI PhylomeDB P0AB20 http://phylomedb.org/?seqid=P0AB20 ProteinModelPortal P0AB20 http://www.proteinmodelportal.org/query/uniprot/P0AB20 PubMed 15569148 http://www.ncbi.nlm.nih.gov/pubmed/15569148 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415486 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415486 RefSeq WP_001295356 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295356 SMART SM00992 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00992 SMR P0AB20 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AB20 STRING 511145.b0966 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0966&targetmode=cogs STRING COG3785 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3785&targetmode=cogs SUPFAM SSF141255 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF141255 TIGRFAMs TIGR02097 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02097 UniProtKB HSPQ_ECOLI http://www.uniprot.org/uniprot/HSPQ_ECOLI UniProtKB-AC P0AB20 http://www.uniprot.org/uniprot/P0AB20 charge swissprot:HSPQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HSPQ_ECOLI eggNOG COG3785 http://eggnogapi.embl.de/nog_data/html/tree/COG3785 eggNOG ENOG4105GSS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105GSS epestfind swissprot:HSPQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HSPQ_ECOLI garnier swissprot:HSPQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HSPQ_ECOLI helixturnhelix swissprot:HSPQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HSPQ_ECOLI hmoment swissprot:HSPQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HSPQ_ECOLI iep swissprot:HSPQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HSPQ_ECOLI inforesidue swissprot:HSPQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HSPQ_ECOLI octanol swissprot:HSPQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HSPQ_ECOLI pepcoil swissprot:HSPQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HSPQ_ECOLI pepdigest swissprot:HSPQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HSPQ_ECOLI pepinfo swissprot:HSPQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HSPQ_ECOLI pepnet swissprot:HSPQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HSPQ_ECOLI pepstats swissprot:HSPQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HSPQ_ECOLI pepwheel swissprot:HSPQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HSPQ_ECOLI pepwindow swissprot:HSPQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HSPQ_ECOLI sigcleave swissprot:HSPQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HSPQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4260957 423 # CATALYTIC ACTIVITY Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. {ECO:0000269|PubMed 10348860}. # CDD cd00115 LMWPc # DISRUPTION PHENOTYPE WZB_ECOLI No phosphorylation of Wzc (PubMed 11090276). Loss of mucoid colony phenotype, greatly increased susceptibility to contact-dependent growth inhibition (CDI) (PubMed 18761695). {ECO 0000269|PubMed 11090276, ECO 0000269|PubMed 18761695}. # EcoGene EG13567 wzb # FUNCTION WZB_ECOLI Dephosphorylates Wzc (PubMed 10348860). Required for the extracellular polysaccharide colanic acid synthesis, probably involved in the export of colanic acid from the cell to medium (PubMed 11090276). Involved in protection of cells against contact-dependent growth inhibition (CDI), probably due to the loss of a physical impediment to cell-cell contact. {ECO 0000269|PubMed 10348860, ECO 0000269|PubMed 11090276, ECO 0000269|PubMed 18761695}. # GO_function GO:0004725 protein tyrosine phosphatase activity; IDA:EcoCyc. # GO_process GO:0009242 colanic acid biosynthetic process; IMP:EcoCyc. # GOslim_function GO:0016791 phosphatase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # IntAct P0AAB2 17 # InterPro IPR017867 Tyr_phospatase_low_mol_wt # InterPro IPR023485 Ptyr_pPase_SF # KEGG_Brite ko01000 Enzymes # Organism WZB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11717:SF20 PTHR11717:SF20 # PATHWAY WZB_ECOLI Glycan metabolism; exopolysaccharide biosynthesis. # PATRIC 32119455 VBIEscCol129921_2138 # PDB 2FEK NMR; -; A=1-147 # PIR D64972 D64972 # PRINTS PR00719 LMWPTPASE # Pfam PF01451 LMWPc # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName WZB_ECOLI Low molecular weight protein-tyrosine-phosphatase Wzb # RefSeq NP_416565 NC_000913.3 # RefSeq WP_000482901 NZ_LN832404.1 # SIMILARITY Belongs to the low molecular weight phosphotyrosine protein phosphatase family. {ECO 0000305}. # SMART SM00226 LMWPc # SUPFAM SSF52788 SSF52788 # eggNOG COG0394 LUCA # eggNOG ENOG4105KJF Bacteria BLAST swissprot:WZB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:WZB_ECOLI BioCyc ECOL316407:JW2046-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2046-MONOMER BioCyc EcoCyc:G7106-MONOMER http://biocyc.org/getid?id=EcoCyc:G7106-MONOMER BioCyc MetaCyc:G7106-MONOMER http://biocyc.org/getid?id=MetaCyc:G7106-MONOMER COG COG0394 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0394 COG COG2365 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2365 DOI 10.1006/jmbi.2000.4217 http://dx.doi.org/10.1006/jmbi.2000.4217 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2008.06404.x http://dx.doi.org/10.1111/j.1365-2958.2008.06404.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.3.48 {ECO:0000269|PubMed:10348860} http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.48 {ECO:0000269|PubMed:10348860} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U38473 http://www.ebi.ac.uk/ena/data/view/U38473 ENZYME 3.1.3.48 {ECO:0000269|PubMed:10348860} http://enzyme.expasy.org/EC/3.1.3.48 {ECO:0000269|PubMed:10348860} EchoBASE EB3337 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3337 EcoGene EG13567 http://www.ecogene.org/geneInfo.php?eg_id=EG13567 EnsemblBacteria AAC75122 http://www.ensemblgenomes.org/id/AAC75122 EnsemblBacteria AAC75122 http://www.ensemblgenomes.org/id/AAC75122 EnsemblBacteria BAE76575 http://www.ensemblgenomes.org/id/BAE76575 EnsemblBacteria BAE76575 http://www.ensemblgenomes.org/id/BAE76575 EnsemblBacteria BAE76575 http://www.ensemblgenomes.org/id/BAE76575 EnsemblBacteria b2061 http://www.ensemblgenomes.org/id/b2061 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004725 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004725 GO_process GO:0009242 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009242 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 946564 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946564 HOGENOM HOG000273091 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000273091&db=HOGENOM6 InParanoid P0AAB2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAB2 IntAct P0AAB2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAB2* IntEnz 3.1.3.48 {ECO:0000269|PubMed:10348860} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.48 {ECO:0000269|PubMed:10348860} InterPro IPR017867 http://www.ebi.ac.uk/interpro/entry/IPR017867 InterPro IPR023485 http://www.ebi.ac.uk/interpro/entry/IPR023485 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2046 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2046 KEGG_Gene eco:b2061 http://www.genome.jp/dbget-bin/www_bget?eco:b2061 KEGG_Orthology KO:K01104 http://www.genome.jp/dbget-bin/www_bget?KO:K01104 MINT MINT-8293227 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8293227 OMA CEIAPEM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CEIAPEM PANTHER PTHR11717:SF20 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11717:SF20 PDB 2FEK http://www.ebi.ac.uk/pdbe-srv/view/entry/2FEK PDBsum 2FEK http://www.ebi.ac.uk/pdbsum/2FEK PRINTS PR00719 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00719 PSORT swissprot:WZB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:WZB_ECOLI PSORT-B swissprot:WZB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:WZB_ECOLI PSORT2 swissprot:WZB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:WZB_ECOLI Pfam PF01451 http://pfam.xfam.org/family/PF01451 Phobius swissprot:WZB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:WZB_ECOLI PhylomeDB P0AAB2 http://phylomedb.org/?seqid=P0AAB2 ProteinModelPortal P0AAB2 http://www.proteinmodelportal.org/query/uniprot/P0AAB2 PubMed 10348860 http://www.ncbi.nlm.nih.gov/pubmed/10348860 PubMed 11090276 http://www.ncbi.nlm.nih.gov/pubmed/11090276 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18761695 http://www.ncbi.nlm.nih.gov/pubmed/18761695 PubMed 8759852 http://www.ncbi.nlm.nih.gov/pubmed/8759852 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416565 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416565 RefSeq WP_000482901 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000482901 SMART SM00226 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00226 SMR P0AAB2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAB2 STRING 511145.b2061 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2061&targetmode=cogs STRING COG0394 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0394&targetmode=cogs STRING COG2365 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2365&targetmode=cogs SUPFAM SSF52788 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52788 UniProtKB WZB_ECOLI http://www.uniprot.org/uniprot/WZB_ECOLI UniProtKB-AC P0AAB2 http://www.uniprot.org/uniprot/P0AAB2 charge swissprot:WZB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:WZB_ECOLI eggNOG COG0394 http://eggnogapi.embl.de/nog_data/html/tree/COG0394 eggNOG ENOG4105KJF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KJF epestfind swissprot:WZB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:WZB_ECOLI garnier swissprot:WZB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:WZB_ECOLI helixturnhelix swissprot:WZB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:WZB_ECOLI hmoment swissprot:WZB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:WZB_ECOLI iep swissprot:WZB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:WZB_ECOLI inforesidue swissprot:WZB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:WZB_ECOLI octanol swissprot:WZB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:WZB_ECOLI pepcoil swissprot:WZB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:WZB_ECOLI pepdigest swissprot:WZB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:WZB_ECOLI pepinfo swissprot:WZB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:WZB_ECOLI pepnet swissprot:WZB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:WZB_ECOLI pepstats swissprot:WZB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:WZB_ECOLI pepwheel swissprot:WZB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:WZB_ECOLI pepwindow swissprot:WZB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:WZB_ECOLI sigcleave swissprot:WZB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:WZB_ECOLI ## Database ID URL or Descriptions # AltName PEPD_ECOLI Aminoacyl-histidine dipeptidase # AltName PEPD_ECOLI Beta-alanyl-histidine dipeptidase # AltName PEPD_ECOLI Carnosinase # AltName PEPD_ECOLI Cysteinylglycinase # AltName PEPD_ECOLI Peptidase D # AltName PEPD_ECOLI Xaa-His dipeptidase # BIOPHYSICOCHEMICAL PROPERTIES PEPD_ECOLI pH dependence Optimum pH is 9. {ECO 0000269|PubMed 7988883}; Temperature dependence Optimum temperature is 37 degrees Celsius. {ECO 0000269|PubMed 7988883}; # BioGrid 4259765 16 # CATALYTIC ACTIVITY PEPD_ECOLI Hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids. {ECO 0000269|PubMed 355237, ECO 0000269|PubMed 7988883}. # CDD cd03890 M20_pepD # COFACTOR PEPD_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 7988883}; Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000269|PubMed 7988883}; Note=Binds 2 Zn(2+) ions per subunit. Can also use Co(2+). {ECO 0000269|PubMed 7988883}; # DISRUPTION PHENOTYPE A quadruple peptidase disruption (pepA, pepB, pepD and pepN) does not grow in M9 minimal medium, grows better when supplemented with casamino acids (PubMed:20067529). {ECO 0000269|PubMed:20067529}. # ENZYME REGULATION Inhibited by metal chelators. {ECO:0000269|PubMed 7988883}. # EcoGene EG10695 pepD # FUNCTION PEPD_ECOLI Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipeptide amides and formyl amino acids are hydrolyzed. Also shows cysteinylglycinase activity, which is sufficient for E.coli to utilize cysteinylglycine as a cysteine source. {ECO 0000269|PubMed 11157967, ECO 0000269|PubMed 20067529, ECO 0000269|PubMed 355237, ECO 0000269|PubMed 7988883}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_function GO:0016805 dipeptidase activity; IMP:EcoCyc. # GO_function GO:0070573 metallodipeptidase activity; IDA:EcoCyc. # GO_function GO:0102008 cytosolic dipeptidase activity; IEA:UniProtKB-EC. # GO_process GO:0043171 peptide catabolic process; IGI:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # IntAct P15288 69 # InterPro IPR001160 Peptidase_M20C # InterPro IPR002933 Peptidase_M20 # InterPro IPR011650 Peptidase_M20_dimer # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # KEGG_Pathway ko00480 Glutathione metabolism # Organism PEPD_ECOLI Escherichia coli (strain K12) # PATRIC 32115589 VBIEscCol129921_0239 # PIR JU0300 JU0300 # PIRSF PIRSF016599 Xaa-His_dipept # PRINTS PR00934 XHISDIPTASE # Pfam PF01546 Peptidase_M20 # Pfam PF07687 M20_dimer # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PEPD_ECOLI Cytosol non-specific dipeptidase # RefSeq NP_414772 NC_000913.3 # RefSeq WP_001292994 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase M20C family. {ECO 0000305}. # TIGRFAMs TIGR01893 aa-his-dipept # eggNOG COG2195 LUCA # eggNOG ENOG4105CIN Bacteria BLAST swissprot:PEPD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PEPD_ECOLI BioCyc ECOL316407:JW0227-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0227-MONOMER BioCyc EcoCyc:EG10695-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10695-MONOMER BioCyc MetaCyc:EG10695-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10695-MONOMER COG COG2195 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2195 DIP DIP-10456N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10456N DOI 10.1007/BF00427031 http://dx.doi.org/10.1007/BF00427031 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1111/j.1574-6968.1994.tb07215.x http://dx.doi.org/10.1111/j.1574-6968.1994.tb07215.x DOI 10.1111/j.1574-6968.2009.01879.x http://dx.doi.org/10.1111/j.1574-6968.2009.01879.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.183.4.1489-1490.2001 http://dx.doi.org/10.1128/JB.183.4.1489-1490.2001 EC_number EC:3.4.13.18 http://www.genome.jp/dbget-bin/www_bget?EC:3.4.13.18 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M34034 http://www.ebi.ac.uk/ena/data/view/M34034 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EMBL X14790 http://www.ebi.ac.uk/ena/data/view/X14790 ENZYME 3.4.13.18 http://enzyme.expasy.org/EC/3.4.13.18 EchoBASE EB0689 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0689 EcoGene EG10695 http://www.ecogene.org/geneInfo.php?eg_id=EG10695 EnsemblBacteria AAC73341 http://www.ensemblgenomes.org/id/AAC73341 EnsemblBacteria AAC73341 http://www.ensemblgenomes.org/id/AAC73341 EnsemblBacteria BAA77906 http://www.ensemblgenomes.org/id/BAA77906 EnsemblBacteria BAA77906 http://www.ensemblgenomes.org/id/BAA77906 EnsemblBacteria BAA77906 http://www.ensemblgenomes.org/id/BAA77906 EnsemblBacteria b0237 http://www.ensemblgenomes.org/id/b0237 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0016805 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016805 GO_function GO:0070573 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070573 GO_function GO:0102008 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0102008 GO_process GO:0043171 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043171 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 945013 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945013 HOGENOM HOG000282306 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000282306&db=HOGENOM6 InParanoid P15288 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P15288 IntAct P15288 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P15288* IntEnz 3.4.13.18 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.13.18 InterPro IPR001160 http://www.ebi.ac.uk/interpro/entry/IPR001160 InterPro IPR002933 http://www.ebi.ac.uk/interpro/entry/IPR002933 InterPro IPR011650 http://www.ebi.ac.uk/interpro/entry/IPR011650 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW0227 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0227 KEGG_Gene eco:b0237 http://www.genome.jp/dbget-bin/www_bget?eco:b0237 KEGG_Orthology KO:K01270 http://www.genome.jp/dbget-bin/www_bget?KO:K01270 KEGG_Pathway ko00480 http://www.genome.jp/kegg-bin/show_pathway?ko00480 KEGG_Reaction rn:R00899 http://www.genome.jp/dbget-bin/www_bget?rn:R00899 KEGG_Reaction rn:R04951 http://www.genome.jp/dbget-bin/www_bget?rn:R04951 MINT MINT-1252343 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1252343 OMA KGGYPGW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KGGYPGW PRINTS PR00934 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00934 PSORT swissprot:PEPD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PEPD_ECOLI PSORT-B swissprot:PEPD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PEPD_ECOLI PSORT2 swissprot:PEPD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PEPD_ECOLI Pfam PF01546 http://pfam.xfam.org/family/PF01546 Pfam PF07687 http://pfam.xfam.org/family/PF07687 Phobius swissprot:PEPD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PEPD_ECOLI PhylomeDB P15288 http://phylomedb.org/?seqid=P15288 ProteinModelPortal P15288 http://www.proteinmodelportal.org/query/uniprot/P15288 PubMed 11157967 http://www.ncbi.nlm.nih.gov/pubmed/11157967 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1695895 http://www.ncbi.nlm.nih.gov/pubmed/1695895 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 20067529 http://www.ncbi.nlm.nih.gov/pubmed/20067529 PubMed 2651887 http://www.ncbi.nlm.nih.gov/pubmed/2651887 PubMed 355237 http://www.ncbi.nlm.nih.gov/pubmed/355237 PubMed 7988883 http://www.ncbi.nlm.nih.gov/pubmed/7988883 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414772 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414772 RefSeq WP_001292994 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001292994 SMR P15288 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P15288 STRING 511145.b0237 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0237&targetmode=cogs STRING COG2195 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2195&targetmode=cogs SWISS-2DPAGE P15288 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P15288 TIGRFAMs TIGR01893 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01893 UniProtKB PEPD_ECOLI http://www.uniprot.org/uniprot/PEPD_ECOLI UniProtKB-AC P15288 http://www.uniprot.org/uniprot/P15288 charge swissprot:PEPD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PEPD_ECOLI eggNOG COG2195 http://eggnogapi.embl.de/nog_data/html/tree/COG2195 eggNOG ENOG4105CIN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CIN epestfind swissprot:PEPD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PEPD_ECOLI garnier swissprot:PEPD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PEPD_ECOLI helixturnhelix swissprot:PEPD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PEPD_ECOLI hmoment swissprot:PEPD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PEPD_ECOLI iep swissprot:PEPD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PEPD_ECOLI inforesidue swissprot:PEPD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PEPD_ECOLI octanol swissprot:PEPD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PEPD_ECOLI pepcoil swissprot:PEPD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PEPD_ECOLI pepdigest swissprot:PEPD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PEPD_ECOLI pepinfo swissprot:PEPD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PEPD_ECOLI pepnet swissprot:PEPD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PEPD_ECOLI pepstats swissprot:PEPD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PEPD_ECOLI pepwheel swissprot:PEPD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PEPD_ECOLI pepwindow swissprot:PEPD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PEPD_ECOLI sigcleave swissprot:PEPD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PEPD_ECOLI ## Database ID URL or Descriptions # BioGrid 4260692 7 # EcoGene EG13463 yphB # GO_function GO:0004034 aldose 1-epimerase activity; IBA:GO_Central. # GO_function GO:0030246 carbohydrate binding; IEA:InterPro. # GO_process GO:0006006 glucose metabolic process; IBA:GO_Central. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0033499 galactose catabolic process via UDP-galactose; IBA:GO_Central. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 2.70.98.10 -; 1. # IntAct P76584 3 # InterPro IPR008183 Aldose_1/G6P_1-epimerase # InterPro IPR011013 Gal_mutarotase_SF_dom # InterPro IPR014718 GH-type_carb-bd # Organism YPHB_ECOLI Escherichia coli (strain K12) # PATRIC 32120485 VBIEscCol129921_2645 # PDB 3NRE X-ray; 1.59 A; A/B/C/D=1-290 # PIR G65031 G65031 # Pfam PF01263 Aldose_epim # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YPHB_ECOLI Uncharacterized protein YphB # RefSeq NP_417039 NC_000913.3 # RefSeq WP_000158547 NZ_LN832404.1 # SUPFAM SSF74650 SSF74650 # eggNOG COG2017 LUCA # eggNOG ENOG4108ZKT Bacteria BLAST swissprot:YPHB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YPHB_ECOLI BioCyc ECOL316407:JW2528-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2528-MONOMER BioCyc EcoCyc:G7338-MONOMER http://biocyc.org/getid?id=EcoCyc:G7338-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3236 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3236 EcoGene EG13463 http://www.ecogene.org/geneInfo.php?eg_id=EG13463 EnsemblBacteria AAC75597 http://www.ensemblgenomes.org/id/AAC75597 EnsemblBacteria AAC75597 http://www.ensemblgenomes.org/id/AAC75597 EnsemblBacteria BAE76730 http://www.ensemblgenomes.org/id/BAE76730 EnsemblBacteria BAE76730 http://www.ensemblgenomes.org/id/BAE76730 EnsemblBacteria BAE76730 http://www.ensemblgenomes.org/id/BAE76730 EnsemblBacteria b2544 http://www.ensemblgenomes.org/id/b2544 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004034 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004034 GO_function GO:0030246 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030246 GO_process GO:0006006 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006006 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0033499 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033499 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 2.70.98.10 http://www.cathdb.info/version/latest/superfamily/2.70.98.10 GeneID 947017 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947017 HOGENOM HOG000256089 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000256089&db=HOGENOM6 InParanoid P76584 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76584 IntAct P76584 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76584* InterPro IPR008183 http://www.ebi.ac.uk/interpro/entry/IPR008183 InterPro IPR011013 http://www.ebi.ac.uk/interpro/entry/IPR011013 InterPro IPR014718 http://www.ebi.ac.uk/interpro/entry/IPR014718 KEGG_Gene ecj:JW2528 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2528 KEGG_Gene eco:b2544 http://www.genome.jp/dbget-bin/www_bget?eco:b2544 OMA PIHGSAW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PIHGSAW PDB 3NRE http://www.ebi.ac.uk/pdbe-srv/view/entry/3NRE PDBsum 3NRE http://www.ebi.ac.uk/pdbsum/3NRE PSORT swissprot:YPHB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YPHB_ECOLI PSORT-B swissprot:YPHB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YPHB_ECOLI PSORT2 swissprot:YPHB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YPHB_ECOLI Pfam PF01263 http://pfam.xfam.org/family/PF01263 Phobius swissprot:YPHB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YPHB_ECOLI PhylomeDB P76584 http://phylomedb.org/?seqid=P76584 ProteinModelPortal P76584 http://www.proteinmodelportal.org/query/uniprot/P76584 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417039 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417039 RefSeq WP_000158547 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000158547 SMR P76584 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76584 STRING 511145.b2544 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2544&targetmode=cogs SUPFAM SSF74650 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF74650 UniProtKB YPHB_ECOLI http://www.uniprot.org/uniprot/YPHB_ECOLI UniProtKB-AC P76584 http://www.uniprot.org/uniprot/P76584 charge swissprot:YPHB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YPHB_ECOLI eggNOG COG2017 http://eggnogapi.embl.de/nog_data/html/tree/COG2017 eggNOG ENOG4108ZKT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZKT epestfind swissprot:YPHB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YPHB_ECOLI garnier swissprot:YPHB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YPHB_ECOLI helixturnhelix swissprot:YPHB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YPHB_ECOLI hmoment swissprot:YPHB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YPHB_ECOLI iep swissprot:YPHB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YPHB_ECOLI inforesidue swissprot:YPHB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YPHB_ECOLI octanol swissprot:YPHB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YPHB_ECOLI pepcoil swissprot:YPHB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YPHB_ECOLI pepdigest swissprot:YPHB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YPHB_ECOLI pepinfo swissprot:YPHB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YPHB_ECOLI pepnet swissprot:YPHB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YPHB_ECOLI pepstats swissprot:YPHB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YPHB_ECOLI pepwheel swissprot:YPHB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YPHB_ECOLI pepwindow swissprot:YPHB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YPHB_ECOLI sigcleave swissprot:YPHB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YPHB_ECOLI ## Database ID URL or Descriptions # BioGrid 4262218 8 # CDD cd00242 Ecotin # EcoGene EG10255 eco # FUNCTION ECOT_ECOLI General inhibitor of pancreatic serine proteases inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases. The strength of inhibition does not appear to be correlated with a particular protease specificity. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0004867 serine-type endopeptidase inhibitor activity; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0030234 enzyme regulator activity # Gene3D 2.60.40.550 -; 1. # Gene3D 4.10.1230.10 -; 1. # HAMAP MF_00706 Ecotin # INTERACTION ECOT_ECOLI P03951 F11 (xeno); NbExp=3; IntAct=EBI-1029159, EBI-1041019; P00763 Prss2 (xeno); NbExp=2; IntAct=EBI-1029159, EBI-1029166; # IntAct P23827 6 # InterPro IPR005658 Prot_inh_ecotin # InterPro IPR023084 Prot_inh_ecotin_gammaproteobac # InterPro IPR023189 Prot_inh_ecotin_dom # InterPro IPR027438 Ecotin_C # Organism ECOT_ECOLI Escherichia coli (strain K12) # PATRIC 32119777 VBIEscCol129921_2298 # PDB 1AZZ X-ray; 2.30 A; C/D=21-162 # PDB 1ECY X-ray; 2.19 A; A=21-162 # PDB 1ECZ X-ray; 2.68 A; A/B=21-162 # PDB 1EZS X-ray; 2.30 A; A/B=21-162 # PDB 1EZU X-ray; 2.40 A; A/B=21-162 # PDB 1FI8 X-ray; 2.20 A; C/E=21-109, D/F=105-162 # PDB 1ID5 X-ray; 2.50 A; I=21-162 # PDB 1IFG X-ray; 2.00 A; A=26-162 # PDB 1N8O X-ray; 2.00 A; E=21-162 # PDB 1P0S X-ray; 2.80 A; E=21-162 # PDB 1SLU X-ray; 1.80 A; A=21-162 # PDB 1SLV X-ray; 2.30 A; A=21-162 # PDB 1SLW X-ray; 2.00 A; A=21-162 # PDB 1SLX X-ray; 2.20 A; A=21-162 # PDB 1XX9 X-ray; 2.20 A; C/D=21-162 # PDB 1XXD X-ray; 2.91 A; C/D=21-162 # PDB 1XXF X-ray; 2.60 A; C/D=21-162 # PDB 4IW4 X-ray; 3.20 A; C/D=21-162 # PDB 4NIY X-ray; 2.84 A; E/F/G/H=21-162 # PIR A38742 A38742 # PIRSF PIRSF006865 Prot_inh_ecotin # Pfam PF03974 Ecotin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ECOT_ECOLI Ecotin # RefSeq NP_416713 NC_000913.3 # RefSeq WP_000849209 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA16410.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the protease inhibitor I11 (ecotin) family. {ECO 0000305}. # SUBCELLULAR LOCATION ECOT_ECOLI Periplasm. # SUBUNIT ECOT_ECOLI Homodimer. # SUPFAM SSF49772 SSF49772 # eggNOG COG4574 LUCA # eggNOG ENOG4108QSZ Bacteria BLAST swissprot:ECOT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ECOT_ECOLI BioCyc ECOL316407:JW2197-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2197-MONOMER BioCyc EcoCyc:EG10255-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10255-MONOMER COG COG4574 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4574 DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1002/pro.5560040201 http://dx.doi.org/10.1002/pro.5560040201 DOI 10.1002/pro.5560051110 http://dx.doi.org/10.1002/pro.5560051110 DOI 10.1006/jmbi.2000.3812 http://dx.doi.org/10.1006/jmbi.2000.3812 DOI 10.1016/0014-5793(91)80014-T http://dx.doi.org/10.1016/0014-5793(91)80014-T DOI 10.1021/bi010712h http://dx.doi.org/10.1021/bi010712h DOI 10.1021/bi9617522 http://dx.doi.org/10.1021/bi9617522 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M60876 http://www.ebi.ac.uk/ena/data/view/M60876 EMBL U00008 http://www.ebi.ac.uk/ena/data/view/U00008 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X61951 http://www.ebi.ac.uk/ena/data/view/X61951 EchoBASE EB0251 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0251 EcoGene EG10255 http://www.ecogene.org/geneInfo.php?eg_id=EG10255 EnsemblBacteria AAC75269 http://www.ensemblgenomes.org/id/AAC75269 EnsemblBacteria AAC75269 http://www.ensemblgenomes.org/id/AAC75269 EnsemblBacteria BAA15992 http://www.ensemblgenomes.org/id/BAA15992 EnsemblBacteria BAA15992 http://www.ensemblgenomes.org/id/BAA15992 EnsemblBacteria BAA15992 http://www.ensemblgenomes.org/id/BAA15992 EnsemblBacteria b2209 http://www.ensemblgenomes.org/id/b2209 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0004867 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004867 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 Gene3D 2.60.40.550 http://www.cathdb.info/version/latest/superfamily/2.60.40.550 Gene3D 4.10.1230.10 http://www.cathdb.info/version/latest/superfamily/4.10.1230.10 GeneID 946700 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946700 HAMAP MF_00706 http://hamap.expasy.org/unirule/MF_00706 HOGENOM HOG000263245 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000263245&db=HOGENOM6 InParanoid P23827 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23827 IntAct P23827 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P23827* InterPro IPR005658 http://www.ebi.ac.uk/interpro/entry/IPR005658 InterPro IPR023084 http://www.ebi.ac.uk/interpro/entry/IPR023084 InterPro IPR023189 http://www.ebi.ac.uk/interpro/entry/IPR023189 InterPro IPR027438 http://www.ebi.ac.uk/interpro/entry/IPR027438 KEGG_Gene ecj:JW2197 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2197 KEGG_Gene eco:b2209 http://www.genome.jp/dbget-bin/www_bget?eco:b2209 KEGG_Orthology KO:K08276 http://www.genome.jp/dbget-bin/www_bget?KO:K08276 MINT MINT-276115 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-276115 OMA PKAEKGM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PKAEKGM PDB 1AZZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1AZZ PDB 1ECY http://www.ebi.ac.uk/pdbe-srv/view/entry/1ECY PDB 1ECZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1ECZ PDB 1EZS http://www.ebi.ac.uk/pdbe-srv/view/entry/1EZS PDB 1EZU http://www.ebi.ac.uk/pdbe-srv/view/entry/1EZU PDB 1FI8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1FI8 PDB 1ID5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ID5 PDB 1IFG http://www.ebi.ac.uk/pdbe-srv/view/entry/1IFG PDB 1N8O http://www.ebi.ac.uk/pdbe-srv/view/entry/1N8O PDB 1P0S http://www.ebi.ac.uk/pdbe-srv/view/entry/1P0S PDB 1SLU http://www.ebi.ac.uk/pdbe-srv/view/entry/1SLU PDB 1SLV http://www.ebi.ac.uk/pdbe-srv/view/entry/1SLV PDB 1SLW http://www.ebi.ac.uk/pdbe-srv/view/entry/1SLW PDB 1SLX http://www.ebi.ac.uk/pdbe-srv/view/entry/1SLX PDB 1XX9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1XX9 PDB 1XXD http://www.ebi.ac.uk/pdbe-srv/view/entry/1XXD PDB 1XXF http://www.ebi.ac.uk/pdbe-srv/view/entry/1XXF PDB 4IW4 http://www.ebi.ac.uk/pdbe-srv/view/entry/4IW4 PDB 4NIY http://www.ebi.ac.uk/pdbe-srv/view/entry/4NIY PDBsum 1AZZ http://www.ebi.ac.uk/pdbsum/1AZZ PDBsum 1ECY http://www.ebi.ac.uk/pdbsum/1ECY PDBsum 1ECZ http://www.ebi.ac.uk/pdbsum/1ECZ PDBsum 1EZS http://www.ebi.ac.uk/pdbsum/1EZS PDBsum 1EZU http://www.ebi.ac.uk/pdbsum/1EZU PDBsum 1FI8 http://www.ebi.ac.uk/pdbsum/1FI8 PDBsum 1ID5 http://www.ebi.ac.uk/pdbsum/1ID5 PDBsum 1IFG http://www.ebi.ac.uk/pdbsum/1IFG PDBsum 1N8O http://www.ebi.ac.uk/pdbsum/1N8O PDBsum 1P0S http://www.ebi.ac.uk/pdbsum/1P0S PDBsum 1SLU http://www.ebi.ac.uk/pdbsum/1SLU PDBsum 1SLV http://www.ebi.ac.uk/pdbsum/1SLV PDBsum 1SLW http://www.ebi.ac.uk/pdbsum/1SLW PDBsum 1SLX http://www.ebi.ac.uk/pdbsum/1SLX PDBsum 1XX9 http://www.ebi.ac.uk/pdbsum/1XX9 PDBsum 1XXD http://www.ebi.ac.uk/pdbsum/1XXD PDBsum 1XXF http://www.ebi.ac.uk/pdbsum/1XXF PDBsum 4IW4 http://www.ebi.ac.uk/pdbsum/4IW4 PDBsum 4NIY http://www.ebi.ac.uk/pdbsum/4NIY PSORT swissprot:ECOT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ECOT_ECOLI PSORT-B swissprot:ECOT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ECOT_ECOLI PSORT2 swissprot:ECOT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ECOT_ECOLI Pfam PF03974 http://pfam.xfam.org/family/PF03974 Phobius swissprot:ECOT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ECOT_ECOLI PhylomeDB P23827 http://phylomedb.org/?seqid=P23827 ProteinModelPortal P23827 http://www.proteinmodelportal.org/query/uniprot/P23827 PubMed 10843853 http://www.ncbi.nlm.nih.gov/pubmed/10843853 PubMed 11513582 http://www.ncbi.nlm.nih.gov/pubmed/11513582 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1879537 http://www.ncbi.nlm.nih.gov/pubmed/1879537 PubMed 2007606 http://www.ncbi.nlm.nih.gov/pubmed/2007606 PubMed 7757004 http://www.ncbi.nlm.nih.gov/pubmed/7757004 PubMed 8156987 http://www.ncbi.nlm.nih.gov/pubmed/8156987 PubMed 8931142 http://www.ncbi.nlm.nih.gov/pubmed/8931142 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9154920 http://www.ncbi.nlm.nih.gov/pubmed/9154920 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_416713 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416713 RefSeq WP_000849209 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000849209 SMR P23827 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P23827 STRING 511145.b2209 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2209&targetmode=cogs STRING COG4574 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4574&targetmode=cogs SUPFAM SSF49772 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49772 UniProtKB ECOT_ECOLI http://www.uniprot.org/uniprot/ECOT_ECOLI UniProtKB-AC P23827 http://www.uniprot.org/uniprot/P23827 charge swissprot:ECOT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ECOT_ECOLI eggNOG COG4574 http://eggnogapi.embl.de/nog_data/html/tree/COG4574 eggNOG ENOG4108QSZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108QSZ epestfind swissprot:ECOT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ECOT_ECOLI garnier swissprot:ECOT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ECOT_ECOLI helixturnhelix swissprot:ECOT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ECOT_ECOLI hmoment swissprot:ECOT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ECOT_ECOLI iep swissprot:ECOT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ECOT_ECOLI inforesidue swissprot:ECOT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ECOT_ECOLI octanol swissprot:ECOT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ECOT_ECOLI pepcoil swissprot:ECOT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ECOT_ECOLI pepdigest swissprot:ECOT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ECOT_ECOLI pepinfo swissprot:ECOT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ECOT_ECOLI pepnet swissprot:ECOT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ECOT_ECOLI pepstats swissprot:ECOT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ECOT_ECOLI pepwheel swissprot:ECOT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ECOT_ECOLI pepwindow swissprot:ECOT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ECOT_ECOLI sigcleave swissprot:ECOT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ECOT_ECOLI ## Database ID URL or Descriptions # BioGrid 4260874 15 # EcoGene EG12727 ygjP # InterPro IPR002725 DUF45 # Organism YGJP_ECOLI Escherichia coli (strain K12) # PATRIC 32121588 VBIEscCol129921_3180 # PIR B65097 B65097 # Pfam PF01863 DUF45 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGJP_ECOLI Uncharacterized protein YgjP # RefSeq NP_417556 NC_000913.3 # RefSeq WP_001333820 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA57886.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # eggNOG COG1451 LUCA # eggNOG ENOG4108VKG Bacteria BLAST swissprot:YGJP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGJP_ECOLI BioCyc ECOL316407:JW5514-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5514-MONOMER BioCyc EcoCyc:G7604-MONOMER http://biocyc.org/getid?id=EcoCyc:G7604-MONOMER COG COG1451 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1451 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2586 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2586 EcoGene EG12727 http://www.ecogene.org/geneInfo.php?eg_id=EG12727 EnsemblBacteria AAC76120 http://www.ensemblgenomes.org/id/AAC76120 EnsemblBacteria AAC76120 http://www.ensemblgenomes.org/id/AAC76120 EnsemblBacteria BAE77135 http://www.ensemblgenomes.org/id/BAE77135 EnsemblBacteria BAE77135 http://www.ensemblgenomes.org/id/BAE77135 EnsemblBacteria BAE77135 http://www.ensemblgenomes.org/id/BAE77135 EnsemblBacteria b3085 http://www.ensemblgenomes.org/id/b3085 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947650 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947650 HOGENOM HOG000276637 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276637&db=HOGENOM6 InParanoid P42597 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P42597 InterPro IPR002725 http://www.ebi.ac.uk/interpro/entry/IPR002725 KEGG_Gene ecj:JW5514 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5514 KEGG_Gene eco:b3085 http://www.genome.jp/dbget-bin/www_bget?eco:b3085 KEGG_Orthology KO:K07043 http://www.genome.jp/dbget-bin/www_bget?KO:K07043 OMA LCCYMEP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LCCYMEP PSORT swissprot:YGJP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGJP_ECOLI PSORT-B swissprot:YGJP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGJP_ECOLI PSORT2 swissprot:YGJP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGJP_ECOLI Pfam PF01863 http://pfam.xfam.org/family/PF01863 Phobius swissprot:YGJP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGJP_ECOLI PhylomeDB P42597 http://phylomedb.org/?seqid=P42597 ProteinModelPortal P42597 http://www.proteinmodelportal.org/query/uniprot/P42597 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417556 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417556 RefSeq WP_001333820 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001333820 STRING 511145.b3085 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3085&targetmode=cogs STRING COG1451 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1451&targetmode=cogs UniProtKB YGJP_ECOLI http://www.uniprot.org/uniprot/YGJP_ECOLI UniProtKB-AC P42597 http://www.uniprot.org/uniprot/P42597 charge swissprot:YGJP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGJP_ECOLI eggNOG COG1451 http://eggnogapi.embl.de/nog_data/html/tree/COG1451 eggNOG ENOG4108VKG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108VKG epestfind swissprot:YGJP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGJP_ECOLI garnier swissprot:YGJP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGJP_ECOLI helixturnhelix swissprot:YGJP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGJP_ECOLI hmoment swissprot:YGJP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGJP_ECOLI iep swissprot:YGJP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGJP_ECOLI inforesidue swissprot:YGJP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGJP_ECOLI octanol swissprot:YGJP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGJP_ECOLI pepcoil swissprot:YGJP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGJP_ECOLI pepdigest swissprot:YGJP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGJP_ECOLI pepinfo swissprot:YGJP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGJP_ECOLI pepnet swissprot:YGJP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGJP_ECOLI pepstats swissprot:YGJP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGJP_ECOLI pepwheel swissprot:YGJP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGJP_ECOLI pepwindow swissprot:YGJP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGJP_ECOLI sigcleave swissprot:YGJP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGJP_ECOLI ## Database ID URL or Descriptions # BioGrid 4260476 11 # EcoGene EG12048 yejK # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-HAMAP. # GO_component GO:0043590 bacterial nucleoid; IDA:EcoCyc. # GO_function GO:0003690 double-stranded DNA binding; IDA:EcoCyc. # GO_function GO:0003727 single-stranded RNA binding; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0043226 organelle # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0003723 RNA binding # HAMAP MF_00730 NdpA # IntAct P33920 3 # InterPro IPR007358 Nucleoid_associated_NdpA # Organism NDPA_ECOLI Escherichia coli (strain K12) # PATRIC 32119727 VBIEscCol129921_2274 # PIR A64988 A64988 # Pfam PF04245 NA37 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NDPA_ECOLI Nucleoid-associated protein YejK # RefSeq NP_416691 NC_000913.3 # RefSeq WP_000050793 NZ_LN832404.1 # SIMILARITY Belongs to the YejK family. {ECO 0000305}. # SUBCELLULAR LOCATION NDPA_ECOLI Cytoplasm, nucleoid. # eggNOG COG3081 LUCA # eggNOG ENOG4106V8H Bacteria BLAST swissprot:NDPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NDPA_ECOLI BioCyc ECOL316407:JW2174-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2174-MONOMER BioCyc EcoCyc:EG12048-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12048-MONOMER COG COG3081 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3081 DIP DIP-11939N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11939N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00008 http://www.ebi.ac.uk/ena/data/view/U00008 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1980 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1980 EcoGene EG12048 http://www.ecogene.org/geneInfo.php?eg_id=EG12048 EnsemblBacteria AAC75247 http://www.ensemblgenomes.org/id/AAC75247 EnsemblBacteria AAC75247 http://www.ensemblgenomes.org/id/AAC75247 EnsemblBacteria BAE76651 http://www.ensemblgenomes.org/id/BAE76651 EnsemblBacteria BAE76651 http://www.ensemblgenomes.org/id/BAE76651 EnsemblBacteria BAE76651 http://www.ensemblgenomes.org/id/BAE76651 EnsemblBacteria b2186 http://www.ensemblgenomes.org/id/b2186 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0043590 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043590 GO_function GO:0003690 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003690 GO_function GO:0003727 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003727 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0043226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GeneID 946690 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946690 HAMAP MF_00730 http://hamap.expasy.org/unirule/MF_00730 HOGENOM HOG000275814 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275814&db=HOGENOM6 InParanoid P33920 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33920 IntAct P33920 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33920* InterPro IPR007358 http://www.ebi.ac.uk/interpro/entry/IPR007358 KEGG_Gene ecj:JW2174 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2174 KEGG_Gene eco:b2186 http://www.genome.jp/dbget-bin/www_bget?eco:b2186 KEGG_Orthology KO:K06899 http://www.genome.jp/dbget-bin/www_bget?KO:K06899 OMA FFMDFLA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FFMDFLA PSORT swissprot:NDPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NDPA_ECOLI PSORT-B swissprot:NDPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NDPA_ECOLI PSORT2 swissprot:NDPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NDPA_ECOLI Pfam PF04245 http://pfam.xfam.org/family/PF04245 Phobius swissprot:NDPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NDPA_ECOLI PhylomeDB P33920 http://phylomedb.org/?seqid=P33920 ProteinModelPortal P33920 http://www.proteinmodelportal.org/query/uniprot/P33920 PubMed 10368163 http://www.ncbi.nlm.nih.gov/pubmed/10368163 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416691 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416691 RefSeq WP_000050793 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000050793 SMR P33920 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33920 STRING 511145.b2186 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2186&targetmode=cogs STRING COG3081 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3081&targetmode=cogs UniProtKB NDPA_ECOLI http://www.uniprot.org/uniprot/NDPA_ECOLI UniProtKB-AC P33920 http://www.uniprot.org/uniprot/P33920 charge swissprot:NDPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NDPA_ECOLI eggNOG COG3081 http://eggnogapi.embl.de/nog_data/html/tree/COG3081 eggNOG ENOG4106V8H http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106V8H epestfind swissprot:NDPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NDPA_ECOLI garnier swissprot:NDPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NDPA_ECOLI helixturnhelix swissprot:NDPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NDPA_ECOLI hmoment swissprot:NDPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NDPA_ECOLI iep swissprot:NDPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NDPA_ECOLI inforesidue swissprot:NDPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NDPA_ECOLI octanol swissprot:NDPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NDPA_ECOLI pepcoil swissprot:NDPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NDPA_ECOLI pepdigest swissprot:NDPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NDPA_ECOLI pepinfo swissprot:NDPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NDPA_ECOLI pepnet swissprot:NDPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NDPA_ECOLI pepstats swissprot:NDPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NDPA_ECOLI pepwheel swissprot:NDPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NDPA_ECOLI pepwindow swissprot:NDPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NDPA_ECOLI sigcleave swissprot:NDPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NDPA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261458 6 # EcoGene EG12603 yjgZ # IntAct P39351 13 # Organism YJGZ_ECOLI Escherichia coli (strain K12) # PIR S56502 S56502 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJGZ_ECOLI Uncharacterized protein YjgZ # RefSeq NP_418697 NC_000913.3 BLAST swissprot:YJGZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJGZ_ECOLI BioCyc ECOL316407:JW4236-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4236-MONOMER BioCyc EcoCyc:G7899-MONOMER http://biocyc.org/getid?id=EcoCyc:G7899-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2487 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2487 EcoGene EG12603 http://www.ecogene.org/geneInfo.php?eg_id=EG12603 EnsemblBacteria AAC77233 http://www.ensemblgenomes.org/id/AAC77233 EnsemblBacteria AAC77233 http://www.ensemblgenomes.org/id/AAC77233 EnsemblBacteria BAE78271 http://www.ensemblgenomes.org/id/BAE78271 EnsemblBacteria BAE78271 http://www.ensemblgenomes.org/id/BAE78271 EnsemblBacteria BAE78271 http://www.ensemblgenomes.org/id/BAE78271 EnsemblBacteria b4277 http://www.ensemblgenomes.org/id/b4277 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 948804 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948804 HOGENOM HOG000054885 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000054885&db=HOGENOM6 IntAct P39351 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39351* KEGG_Gene ecj:JW4236 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4236 KEGG_Gene eco:b4277 http://www.genome.jp/dbget-bin/www_bget?eco:b4277 PSORT swissprot:YJGZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJGZ_ECOLI PSORT-B swissprot:YJGZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJGZ_ECOLI PSORT2 swissprot:YJGZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJGZ_ECOLI Phobius swissprot:YJGZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJGZ_ECOLI ProteinModelPortal P39351 http://www.proteinmodelportal.org/query/uniprot/P39351 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418697 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418697 SMR P39351 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39351 STRING 511145.b4277 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4277&targetmode=cogs UniProtKB YJGZ_ECOLI http://www.uniprot.org/uniprot/YJGZ_ECOLI UniProtKB-AC P39351 http://www.uniprot.org/uniprot/P39351 charge swissprot:YJGZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJGZ_ECOLI epestfind swissprot:YJGZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJGZ_ECOLI garnier swissprot:YJGZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJGZ_ECOLI helixturnhelix swissprot:YJGZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJGZ_ECOLI hmoment swissprot:YJGZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJGZ_ECOLI iep swissprot:YJGZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJGZ_ECOLI inforesidue swissprot:YJGZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJGZ_ECOLI octanol swissprot:YJGZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJGZ_ECOLI pepcoil swissprot:YJGZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJGZ_ECOLI pepdigest swissprot:YJGZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJGZ_ECOLI pepinfo swissprot:YJGZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJGZ_ECOLI pepnet swissprot:YJGZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJGZ_ECOLI pepstats swissprot:YJGZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJGZ_ECOLI pepwheel swissprot:YJGZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJGZ_ECOLI pepwindow swissprot:YJGZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJGZ_ECOLI sigcleave swissprot:YJGZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJGZ_ECOLI ## Database ID URL or Descriptions # AltName Trans-2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase {ECO:0000303|PubMed 2144454} # BIOPHYSICOCHEMICAL PROPERTIES ENTA_ECOLI Kinetic parameters KM=0.26 mM for methyl 2,3-dihydro-2,3-dihydroxybenzoate (at pH 7.4 and 37 degrees Celsius) {ECO 0000269|PubMed 2144454}; KM=0.3 mM for 2,3-dihydro-2,3-dihydroxybenzoate (at pH 7.4 and 37 degrees Celsius) {ECO 0000269|PubMed 2144454}; KM=1.7 mM for methyl-3-hydroxy-1,4-cyclohexadiene-1-carboxylate (at pH 7.4 and 37 degrees Celsius) {ECO 0000269|PubMed 2144454}; KM=1.9 mM for trans-3-hydroxy-2-cyclohexene-1-carboxylate (at pH 7.4 and 37 degrees Celsius) {ECO 0000269|PubMed 2144454}; KM=2.8 mM for cis-3-hydroxy-4-cyclohexene-1-carboxylate (at pH 7.4 and 37 degrees Celsius) {ECO 0000269|PubMed 2144454}; KM=4.1 mM for cis-3-hydroxycyclohexane-1-carboxylic acid (at pH 7.4 and 37 degrees Celsius) {ECO 0000269|PubMed 2144454}; KM=16.5 mM for trans-3,5-cyclohexadiene-1,2-diol (at pH 7.4 and 37 degrees Celsius) {ECO 0000269|PubMed 2144454}; KM=25.2 mM for trans-3-hydroxycyclohexane-1-carboxylic acid (at pH 7.4 and 37 degrees Celsius) {ECO 0000269|PubMed 2144454}; KM=83.3 mM for 2-cyclohexen-1-ol (at pH 7.4 and 37 degrees Celsius) {ECO 0000269|PubMed 2144454}; KM=168 mM for cis-3,5-cyclohexadiene-1,2-diol (at pH 7.4 and 37 degrees Celsius) {ECO 0000269|PubMed 2144454}; Note=Kcat is 5550 min(-1) for dehydrogenase activity with 2,3- dihydro-2,3-dihydroxybenzoate as substrate (at pH 7.4 and 37 degrees Celsius). Kcat is 1380 min(-1) for dehydrogenase activity with cis-3-hydroxy-4-cyclohexene-1-carboxylate as substrate (at pH 7.4 and 37 degrees Celsius). Kcat is 1050 min(- 1) for dehydrogenase activity with 2,3-dihydro-2,3- dihydroxybenzoate as substrate (at pH 7.4 and 37 degrees Celsius). Kcat is 1000 min(-1) for dehydrogenase activity with cis-3,5-cyclohexadiene-1,2-diol as substrate (at pH 7.4 and 37 degrees Celsius). Kcat is 300 min(-1) for dehydrogenase activity with trans-3-hydroxy-2-cyclohexene-1-carboxylate and cis-3- hydroxycyclohexane-1-carboxylic acid as substrates (at pH 7.4 and 37 degrees Celsius). Kcat is 180 min(-1) for dehydrogenase activity with methyl-3-hydroxy-1,4-cyclohexadiene-1-carboxylate as substrate (at pH 7.4 and 37 degrees Celsius). Kcat is 60 min(-1) for dehydrogenase activity with trans-3,5- cyclohexadiene-1,2-diol and 2-cyclohexen-1-ol as substrates (at pH 7.4 and 37 degrees Celsius). Kcat is 44 min(-1) for dehydrogenase activity with trans-3-hydroxycyclohexane-1- carboxylic acid as substrate (at pH 7.4 and 37 degrees Celsius). {ECO 0000269|PubMed 2144454}; # BioGrid 4260984 134 # CATALYTIC ACTIVITY 2,3-dihydro-2,3-dihydroxybenzoate + NAD(+) = 2,3-dihydroxybenzoate + NADH. {ECO:0000269|PubMed 2144454}. # ENZYME REGULATION Inhibited by cis-2-hydroxy-3-cyclohexen-1- carboxylate, cis-2-hydroxycyclohexane-1-carboxylate and trans-2- hydroxycyclohexane-1-carboxylate. {ECO:0000269|PubMed 2144454}. # EcoGene EG10259 entA # FUNCTION ENTA_ECOLI Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3-dihydroxybenzoyl)-serine. Catalyzes the reversible NAD-dependent oxidation of the C3-hydroxyl group of 2,3-dihydro-2,3-dihydroxybenzoate (2,3-diDHB), producing the transient intermediate 2-hydroxy-3-oxo-4,6-cyclohexadiene-1- carboxylate, which undergoes rapid aromatization to the final product, 2,3-dihydroxybenzoate (2,3-DHB). Only the compounds with a C3-hydroxyl group such as methyl 2,3-dihydro-2,3- dihydroxybenzoate, methyl-3-hydroxy-1,4-cyclohexadiene-1- carboxylate, trans-3-hydroxy-2-cyclohexene-1-carboxylate, cis-3- hydroxy-4-cyclohexene-1-carboxylate, cis-3-hydroxycyclohexane-1- carboxylic acid are oxidized to the corresponding ketone products. The stereospecificity of the C3 allylic alcohol group oxidation is 3R in a 1R,3R dihydro substrate. It can also increase the DHB-AMP ligase activity of EntE by interaction EntE. {ECO 0000269|PubMed 21166461, ECO 0000269|PubMed 2144454, ECO 0000269|PubMed 2521622}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0009239 enterobactin biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0019748 secondary metabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.720 -; 1. # INDUCTION Under conditions of iron deficiency and by the fur protein. {ECO:0000269|PubMed 2521621}. # IntAct P15047 8 # InterPro IPR002347 SDR_fam # InterPro IPR003560 DHB_DH # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR020904 Sc_DH/Rdtase_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko01053 Biosynthesis of siderophore group nonribosomal peptides # Organism ENTA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR24322 PTHR24322; 2 # PATHWAY Siderophore biosynthesis; enterobactin biosynthesis. {ECO 0000305}. # PATRIC 32116368 VBIEscCol129921_0624 # PDB 2FWM X-ray; 2.00 A; X=1-248 # PIR A91904 DEECDB # PRINTS PR00080 SDRFAMILY # PRINTS PR01397 DHBDHDRGNASE # PROSITE PS00061 ADH_SHORT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase {ECO:0000303|PubMed 2521622} # RefSeq NP_415128 NC_000913.3 # RefSeq WP_000347651 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40796.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO 0000305}. # SUBUNIT ENTA_ECOLI Homotetramer; dimer of dimers. EntA and EntE interact together. {ECO 0000269|PubMed 16790929, ECO 0000269|PubMed 21166461, ECO 0000269|PubMed 2521622}. # SUPFAM SSF51735 SSF51735 # TIGRFAMs TIGR04316 dhbA_paeA # eggNOG COG1028 LUCA # eggNOG ENOG4105X17 Bacteria BLAST swissprot:ENTA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ENTA_ECOLI BioCyc ECOL316407:JW0588-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0588-MONOMER BioCyc EcoCyc:ENTA-MONOMER http://biocyc.org/getid?id=EcoCyc:ENTA-MONOMER BioCyc MetaCyc:ENTA-MONOMER http://biocyc.org/getid?id=MetaCyc:ENTA-MONOMER COG COG1028 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1028 DIP DIP-9511N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9511N DOI 10.1021/bi00481a006 http://dx.doi.org/10.1021/bi00481a006 DOI 10.1021/bi101558v http://dx.doi.org/10.1021/bi101558v DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1107/S0907444906015824 http://dx.doi.org/10.1107/S0907444906015824 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.3.1.28 {ECO:0000269|PubMed:2144454} http://www.genome.jp/dbget-bin/www_bget?EC:1.3.1.28 {ECO:0000269|PubMed:2144454} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M24143 http://www.ebi.ac.uk/ena/data/view/M24143 EMBL M24148 http://www.ebi.ac.uk/ena/data/view/M24148 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 ENZYME 1.3.1.28 {ECO:0000269|PubMed:2144454} http://enzyme.expasy.org/EC/1.3.1.28 {ECO:0000269|PubMed:2144454} EchoBASE EB0255 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0255 EcoGene EG10259 http://www.ecogene.org/geneInfo.php?eg_id=EG10259 EnsemblBacteria AAC73697 http://www.ensemblgenomes.org/id/AAC73697 EnsemblBacteria AAC73697 http://www.ensemblgenomes.org/id/AAC73697 EnsemblBacteria BAE76351 http://www.ensemblgenomes.org/id/BAE76351 EnsemblBacteria BAE76351 http://www.ensemblgenomes.org/id/BAE76351 EnsemblBacteria BAE76351 http://www.ensemblgenomes.org/id/BAE76351 EnsemblBacteria b0596 http://www.ensemblgenomes.org/id/b0596 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008667 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008667 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0009239 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009239 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0019748 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019748 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 945284 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945284 InParanoid P15047 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P15047 IntAct P15047 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P15047* IntEnz 1.3.1.28 {ECO:0000269|PubMed:2144454} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.3.1.28 {ECO:0000269|PubMed:2144454} InterPro IPR002347 http://www.ebi.ac.uk/interpro/entry/IPR002347 InterPro IPR003560 http://www.ebi.ac.uk/interpro/entry/IPR003560 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR020904 http://www.ebi.ac.uk/interpro/entry/IPR020904 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0588 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0588 KEGG_Gene eco:b0596 http://www.genome.jp/dbget-bin/www_bget?eco:b0596 KEGG_Orthology KO:K00216 http://www.genome.jp/dbget-bin/www_bget?KO:K00216 KEGG_Pathway ko01053 http://www.genome.jp/kegg-bin/show_pathway?ko01053 KEGG_Reaction rn:R01505 http://www.genome.jp/dbget-bin/www_bget?rn:R01505 OMA ACAREMV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ACAREMV PANTHER PTHR24322 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24322 PDB 2FWM http://www.ebi.ac.uk/pdbe-srv/view/entry/2FWM PDBsum 2FWM http://www.ebi.ac.uk/pdbsum/2FWM PRINTS PR00080 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00080 PRINTS PR01397 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01397 PROSITE PS00061 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00061 PSORT swissprot:ENTA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ENTA_ECOLI PSORT-B swissprot:ENTA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ENTA_ECOLI PSORT2 swissprot:ENTA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ENTA_ECOLI Phobius swissprot:ENTA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ENTA_ECOLI PhylomeDB P15047 http://phylomedb.org/?seqid=P15047 ProteinModelPortal P15047 http://www.proteinmodelportal.org/query/uniprot/P15047 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16790929 http://www.ncbi.nlm.nih.gov/pubmed/16790929 PubMed 21166461 http://www.ncbi.nlm.nih.gov/pubmed/21166461 PubMed 2144454 http://www.ncbi.nlm.nih.gov/pubmed/2144454 PubMed 2521621 http://www.ncbi.nlm.nih.gov/pubmed/2521621 PubMed 2521622 http://www.ncbi.nlm.nih.gov/pubmed/2521622 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415128 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415128 RefSeq WP_000347651 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000347651 SMR P15047 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P15047 STRING 511145.b0596 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0596&targetmode=cogs STRING COG1028 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1028&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 TIGRFAMs TIGR04316 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR04316 UniProtKB ENTA_ECOLI http://www.uniprot.org/uniprot/ENTA_ECOLI UniProtKB-AC P15047 http://www.uniprot.org/uniprot/P15047 charge swissprot:ENTA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ENTA_ECOLI eggNOG COG1028 http://eggnogapi.embl.de/nog_data/html/tree/COG1028 eggNOG ENOG4105X17 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105X17 epestfind swissprot:ENTA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ENTA_ECOLI garnier swissprot:ENTA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ENTA_ECOLI helixturnhelix swissprot:ENTA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ENTA_ECOLI hmoment swissprot:ENTA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ENTA_ECOLI iep swissprot:ENTA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ENTA_ECOLI inforesidue swissprot:ENTA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ENTA_ECOLI octanol swissprot:ENTA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ENTA_ECOLI pepcoil swissprot:ENTA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ENTA_ECOLI pepdigest swissprot:ENTA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ENTA_ECOLI pepinfo swissprot:ENTA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ENTA_ECOLI pepnet swissprot:ENTA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ENTA_ECOLI pepstats swissprot:ENTA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ENTA_ECOLI pepwheel swissprot:ENTA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ENTA_ECOLI pepwindow swissprot:ENTA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ENTA_ECOLI sigcleave swissprot:ENTA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ENTA_ECOLI ## Database ID URL or Descriptions # AltName RCSC_ECOLI Capsular synthesis regulator component C # CATALYTIC ACTIVITY ATP + protein L-histidine = ADP + protein N- phospho-L-histidine. {ECO:0000255|HAMAP-Rule MF_00979}. # ENZYME REGULATION RCSC_ECOLI The Rcs phosphorelay may be activated by RcsF. DjlA, LolA and OmpG might act as a regulator of the phosphorelay. Activity is probably up-regulated by YmgA/AriR, and possibly down- regulated by YcgZ, all 3 are connector proteins providing additional signal input into signaling system. {ECO 0000269|PubMed 11758943, ECO 0000269|PubMed 16166540, ECO 0000269|PubMed 19240136}. # EcoGene EG10822 rcsC # FUNCTION RCSC_ECOLI Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane- associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB. RcsC has also phosphatase activity. The system controls expression of genes involved in colanic acid capsule synthesis, biofilm formation and cell division. {ECO 0000255|HAMAP-Rule MF_00979, ECO 0000269|PubMed 10564486, ECO 0000269|PubMed 11309126, ECO 0000269|PubMed 11758943, ECO 0000269|PubMed 11807084, ECO 0000269|PubMed 13129944, ECO 0000269|PubMed 14651646}. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IEA:UniProtKB-HAMAP. # GO_function GO:0000155 phosphorelay sensor kinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_process GO:0000160 phosphorelay signal transduction system; IDA:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:InterPro. # GO_process GO:0044010 single-species biofilm formation; IMP:EcoCyc. # GO_process GO:0046777 protein autophosphorylation; IMP:EcoCyc. # GO_process GO:0071470 cellular response to osmotic stress; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005622 intracellular # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # Gene3D 1.10.287.130 -; 1. # Gene3D 3.30.565.10 -; 1. # HAMAP MF_00979 RcsC # InterPro IPR001789 Sig_transdc_resp-reg_receiver # InterPro IPR003594 HATPase_C # InterPro IPR003661 HisK_dim/P # InterPro IPR004358 Sig_transdc_His_kin-like_C # InterPro IPR005467 His_kinase_dom # InterPro IPR011006 CheY-like_superfamily # InterPro IPR019017 Sig_transdc_His_kin_a/b-loop_C # InterPro IPR030856 RcsC # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01001 Protein kinases # KEGG_Brite ko02022 M00474 RcsC-RcsD-RcsB (capsule synthesis) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # MISCELLANEOUS There is a close linkage between the Rcs and PhoQ/P signaling systems, and both signaling systems respond to certain external divalent cations (zinc and magnesium). {ECO:0000305|PubMed 13129944}. # Organism RCSC_ECOLI Escherichia coli (strain K12) # PDB 2AYX NMR; -; A=700-949 # PDB 2AYY NMR; -; A=700-816 # PDB 2AYZ NMR; -; A=817-949 # PIR H64991 BVECCC # PRINTS PR00344 BCTRLSENSOR # PROSITE PS50109 HIS_KIN # PROSITE PS50110 RESPONSE_REGULATORY # PROSITE PS51426 ABL # PTM RCSC_ECOLI Autophosphorylated. Activation probably requires a transfer of a phosphate group from a His in the transmitter domain to an Asp in the receiver domain. # Pfam PF00072 Response_reg # Pfam PF00512 HisKA # Pfam PF02518 HATPase_c # Pfam PF09456 RcsC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Sensor histidine kinase RcsC {ECO:0000255|HAMAP-Rule MF_00979} # RefSeq NP_416722 NC_000913.3 # RefSeq WP_000876011 NZ_LN832404.1 # SEQUENCE CAUTION RCSC_ECOLI Sequence=AAA24503.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=BAA16001.2; Type=Frameshift; Positions=808; Evidence={ECO 0000305}; Sequence=BAA16014.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; Sequence=BAA16014.1; Type=Frameshift; Positions=808; Evidence={ECO 0000305}; # SIMILARITY Belongs to the RcsC family. {ECO:0000255|HAMAP- Rule MF_00979}. # SIMILARITY Contains 1 ABL domain. {ECO:0000255|HAMAP- Rule MF_00979}. # SIMILARITY Contains 1 PAS (PER-ARNT-SIM) domain. {ECO:0000255|HAMAP-Rule MF_00979}. # SIMILARITY Contains 1 histidine kinase domain. {ECO:0000255|HAMAP-Rule MF_00979}. # SIMILARITY Contains 1 response regulatory domain. {ECO:0000255|PROSITE-ProRule PRU00169}. # SMART SM00387 HATPase_c # SMART SM00388 HisKA # SMART SM00448 REC # SUBCELLULAR LOCATION RCSC_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_00979, ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 2404948}; Multi-pass membrane protein {ECO 0000255|HAMAP-Rule MF_00979, ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 2404948}. # SUBUNIT RCSC_ECOLI Interacts with RcsD. {ECO 0000255|HAMAP-Rule MF_00979, ECO 0000269|PubMed 15476819, ECO 0000269|PubMed 17005198}. # SUPFAM SSF47384 SSF47384 # SUPFAM SSF52172 SSF52172; 2 # SUPFAM SSF55874 SSF55874 # eggNOG ENOG4105BZU Bacteria # eggNOG ENOG410XNMH LUCA BLAST swissprot:RCSC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RCSC_ECOLI DOI 10.1016/j.jmb.2004.08.096 http://dx.doi.org/10.1016/j.jmb.2004.08.096 DOI 10.1016/j.jmb.2006.07.052 http://dx.doi.org/10.1016/j.jmb.2006.07.052 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1999.01605.x http://dx.doi.org/10.1046/j.1365-2958.1999.01605.x DOI 10.1046/j.1365-2958.2001.02393.x http://dx.doi.org/10.1046/j.1365-2958.2001.02393.x DOI 10.1046/j.1365-2958.2003.03815.x http://dx.doi.org/10.1046/j.1365-2958.2003.03815.x DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1101/gad.499409 http://dx.doi.org/10.1101/gad.499409 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.185.19.5735-5746.2003 http://dx.doi.org/10.1128/JB.185.19.5735-5746.2003 DOI 10.1128/JB.187.19.6770-6778.2005 http://dx.doi.org/10.1128/JB.187.19.6770-6778.2005 DOI 10.1128/jb.184.4.1204-1208.2002 http://dx.doi.org/10.1128/jb.184.4.1204-1208.2002 DOI 10.1271/bbb.65.2364 http://dx.doi.org/10.1271/bbb.65.2364 EC_number EC:2.7.13.3 {ECO:0000255|HAMAP-Rule:MF_00979} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.13.3 {ECO:0000255|HAMAP-Rule:MF_00979} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M28242 http://www.ebi.ac.uk/ena/data/view/M28242 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.13.3 {ECO:0000255|HAMAP-Rule:MF_00979} http://enzyme.expasy.org/EC/2.7.13.3 {ECO:0000255|HAMAP-Rule:MF_00979} EchoBASE EB0815 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0815 EcoGene EG10822 http://www.ecogene.org/geneInfo.php?eg_id=EG10822 EnsemblBacteria AAC75278 http://www.ensemblgenomes.org/id/AAC75278 EnsemblBacteria AAC75278 http://www.ensemblgenomes.org/id/AAC75278 EnsemblBacteria BAA16001 http://www.ensemblgenomes.org/id/BAA16001 EnsemblBacteria BAA16001 http://www.ensemblgenomes.org/id/BAA16001 EnsemblBacteria BAA16001 http://www.ensemblgenomes.org/id/BAA16001 EnsemblBacteria BAA16014 http://www.ensemblgenomes.org/id/BAA16014 EnsemblBacteria BAA16014 http://www.ensemblgenomes.org/id/BAA16014 EnsemblBacteria BAA16014 http://www.ensemblgenomes.org/id/BAA16014 EnsemblBacteria b2218 http://www.ensemblgenomes.org/id/b2218 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0000155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000155 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0044010 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044010 GO_process GO:0046777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046777 GO_process GO:0071470 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071470 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.10.287.130 http://www.cathdb.info/version/latest/superfamily/1.10.287.130 Gene3D 3.30.565.10 http://www.cathdb.info/version/latest/superfamily/3.30.565.10 GeneID 948993 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948993 HAMAP MF_00979 http://hamap.expasy.org/unirule/MF_00979 IntAct P0DMC5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0DMC5* IntEnz 2.7.13.3 {ECO:0000255|HAMAP-Rule:MF_00979} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.13.3 {ECO:0000255|HAMAP-Rule:MF_00979} InterPro IPR001789 http://www.ebi.ac.uk/interpro/entry/IPR001789 InterPro IPR003594 http://www.ebi.ac.uk/interpro/entry/IPR003594 InterPro IPR003661 http://www.ebi.ac.uk/interpro/entry/IPR003661 InterPro IPR004358 http://www.ebi.ac.uk/interpro/entry/IPR004358 InterPro IPR005467 http://www.ebi.ac.uk/interpro/entry/IPR005467 InterPro IPR011006 http://www.ebi.ac.uk/interpro/entry/IPR011006 InterPro IPR019017 http://www.ebi.ac.uk/interpro/entry/IPR019017 InterPro IPR030856 http://www.ebi.ac.uk/interpro/entry/IPR030856 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01001 http://www.genome.jp/dbget-bin/www_bget?ko01001 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW5917 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5917 KEGG_Gene ecj:JW5920 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5920 KEGG_Gene eco:b2218 http://www.genome.jp/dbget-bin/www_bget?eco:b2218 KEGG_Orthology KO:K07677 http://www.genome.jp/dbget-bin/www_bget?KO:K07677 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 MINT MINT-1267658 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1267658 OMA TRCWLAV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TRCWLAV PDB 2AYX http://www.ebi.ac.uk/pdbe-srv/view/entry/2AYX PDB 2AYY http://www.ebi.ac.uk/pdbe-srv/view/entry/2AYY PDB 2AYZ http://www.ebi.ac.uk/pdbe-srv/view/entry/2AYZ PDBsum 2AYX http://www.ebi.ac.uk/pdbsum/2AYX PDBsum 2AYY http://www.ebi.ac.uk/pdbsum/2AYY PDBsum 2AYZ http://www.ebi.ac.uk/pdbsum/2AYZ PRINTS PR00344 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00344 PROSITE PS50109 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50109 PROSITE PS50110 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50110 PROSITE PS51426 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51426 PSORT swissprot:RCSC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RCSC_ECOLI PSORT-B swissprot:RCSC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RCSC_ECOLI PSORT2 swissprot:RCSC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RCSC_ECOLI Pfam PF00072 http://pfam.xfam.org/family/PF00072 Pfam PF00512 http://pfam.xfam.org/family/PF00512 Pfam PF02518 http://pfam.xfam.org/family/PF02518 Pfam PF09456 http://pfam.xfam.org/family/PF09456 Phobius swissprot:RCSC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RCSC_ECOLI PhylomeDB P0DMC5 http://phylomedb.org/?seqid=P0DMC5 ProteinModelPortal P0DMC5 http://www.proteinmodelportal.org/query/uniprot/P0DMC5 PubMed 10564486 http://www.ncbi.nlm.nih.gov/pubmed/10564486 PubMed 11309126 http://www.ncbi.nlm.nih.gov/pubmed/11309126 PubMed 11758943 http://www.ncbi.nlm.nih.gov/pubmed/11758943 PubMed 11807084 http://www.ncbi.nlm.nih.gov/pubmed/11807084 PubMed 13129944 http://www.ncbi.nlm.nih.gov/pubmed/13129944 PubMed 14651646 http://www.ncbi.nlm.nih.gov/pubmed/14651646 PubMed 15476819 http://www.ncbi.nlm.nih.gov/pubmed/15476819 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16166540 http://www.ncbi.nlm.nih.gov/pubmed/16166540 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17005198 http://www.ncbi.nlm.nih.gov/pubmed/17005198 PubMed 19240136 http://www.ncbi.nlm.nih.gov/pubmed/19240136 PubMed 2404948 http://www.ncbi.nlm.nih.gov/pubmed/2404948 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416722 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416722 RefSeq WP_000876011 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000876011 SMART SM00387 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00387 SMART SM00388 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00388 SMART SM00448 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00448 SMR P0DMC5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0DMC5 STRING 511145.b2218 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2218&targetmode=cogs SUPFAM SSF47384 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47384 SUPFAM SSF52172 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52172 SUPFAM SSF55874 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55874 UniProtKB RCSC_ECOLI http://www.uniprot.org/uniprot/RCSC_ECOLI UniProtKB-AC P0DMC5 http://www.uniprot.org/uniprot/P0DMC5 charge swissprot:RCSC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RCSC_ECOLI eggNOG ENOG4105BZU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZU eggNOG ENOG410XNMH http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNMH epestfind swissprot:RCSC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RCSC_ECOLI garnier swissprot:RCSC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RCSC_ECOLI helixturnhelix swissprot:RCSC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RCSC_ECOLI hmoment swissprot:RCSC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RCSC_ECOLI iep swissprot:RCSC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RCSC_ECOLI inforesidue swissprot:RCSC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RCSC_ECOLI octanol swissprot:RCSC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RCSC_ECOLI pepcoil swissprot:RCSC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RCSC_ECOLI pepdigest swissprot:RCSC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RCSC_ECOLI pepinfo swissprot:RCSC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RCSC_ECOLI pepnet swissprot:RCSC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RCSC_ECOLI pepstats swissprot:RCSC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RCSC_ECOLI pepwheel swissprot:RCSC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RCSC_ECOLI pepwindow swissprot:RCSC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RCSC_ECOLI sigcleave swissprot:RCSC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RCSC_ECOLI ## Database ID URL or Descriptions # BioGrid 4260347 12 # EcoGene EG13517 yoaE # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0016614 oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro. # GO_function GO:0050660 flavin adenine dinucleotide binding; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # Gene3D 3.30.465.10 -; 1. # InterPro IPR000644 CBS_dom # InterPro IPR005170 Transptr-assoc_dom # InterPro IPR005496 Integral_membrane_TerC # InterPro IPR016166 FAD-bd_2 # InterPro IPR016169 CO_DH_flavot_FAD-bd_sub2 # Organism YOAE_ECOLI Escherichia coli (strain K12) # PATRIC 32118951 VBIEscCol129921_1893 # PIR H64942 H64942 # PROSITE PS51371 CBS; 2 # Pfam PF03471 CorC_HlyC # Pfam PF03741 TerC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YOAE_ECOLI UPF0053 inner membrane protein YoaE # RefSeq NP_416330 NC_000913.3 # RefSeq WP_000394983 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0053 family. {ECO 0000305}. # SIMILARITY Contains 2 CBS domains. {ECO:0000255|PROSITE- ProRule PRU00703}. # SMART SM01091 CorC_HlyC # SUBCELLULAR LOCATION YOAE_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF56176 SSF56176 # eggNOG COG0861 LUCA # eggNOG COG1253 LUCA # eggNOG ENOG4105EE5 Bacteria BLAST swissprot:YOAE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YOAE_ECOLI BioCyc ECOL316407:JW1805-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1805-MONOMER BioCyc EcoCyc:G6997-MONOMER http://biocyc.org/getid?id=EcoCyc:G6997-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3290 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3290 EcoGene EG13517 http://www.ecogene.org/geneInfo.php?eg_id=EG13517 EnsemblBacteria AAC74886 http://www.ensemblgenomes.org/id/AAC74886 EnsemblBacteria AAC74886 http://www.ensemblgenomes.org/id/AAC74886 EnsemblBacteria BAA15623 http://www.ensemblgenomes.org/id/BAA15623 EnsemblBacteria BAA15623 http://www.ensemblgenomes.org/id/BAA15623 EnsemblBacteria BAA15623 http://www.ensemblgenomes.org/id/BAA15623 EnsemblBacteria b1816 http://www.ensemblgenomes.org/id/b1816 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0016614 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016614 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.30.465.10 http://www.cathdb.info/version/latest/superfamily/3.30.465.10 GeneID 946335 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946335 HOGENOM HOG000279402 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000279402&db=HOGENOM6 InParanoid P0AEC0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEC0 IntAct P0AEC0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEC0* InterPro IPR000644 http://www.ebi.ac.uk/interpro/entry/IPR000644 InterPro IPR005170 http://www.ebi.ac.uk/interpro/entry/IPR005170 InterPro IPR005496 http://www.ebi.ac.uk/interpro/entry/IPR005496 InterPro IPR016166 http://www.ebi.ac.uk/interpro/entry/IPR016166 InterPro IPR016169 http://www.ebi.ac.uk/interpro/entry/IPR016169 KEGG_Gene ecj:JW1805 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1805 KEGG_Gene eco:b1816 http://www.genome.jp/dbget-bin/www_bget?eco:b1816 OMA MRFINRH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MRFINRH PROSITE PS51371 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51371 PSORT swissprot:YOAE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YOAE_ECOLI PSORT-B swissprot:YOAE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YOAE_ECOLI PSORT2 swissprot:YOAE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YOAE_ECOLI Pfam PF03471 http://pfam.xfam.org/family/PF03471 Pfam PF03741 http://pfam.xfam.org/family/PF03741 Phobius swissprot:YOAE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YOAE_ECOLI PhylomeDB P0AEC0 http://phylomedb.org/?seqid=P0AEC0 ProteinModelPortal P0AEC0 http://www.proteinmodelportal.org/query/uniprot/P0AEC0 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416330 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416330 RefSeq WP_000394983 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000394983 SMART SM01091 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01091 SMR P0AEC0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEC0 STRING 511145.b1816 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1816&targetmode=cogs SUPFAM SSF56176 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56176 UniProtKB YOAE_ECOLI http://www.uniprot.org/uniprot/YOAE_ECOLI UniProtKB-AC P0AEC0 http://www.uniprot.org/uniprot/P0AEC0 charge swissprot:YOAE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YOAE_ECOLI eggNOG COG0861 http://eggnogapi.embl.de/nog_data/html/tree/COG0861 eggNOG COG1253 http://eggnogapi.embl.de/nog_data/html/tree/COG1253 eggNOG ENOG4105EE5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EE5 epestfind swissprot:YOAE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YOAE_ECOLI garnier swissprot:YOAE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YOAE_ECOLI helixturnhelix swissprot:YOAE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YOAE_ECOLI hmoment swissprot:YOAE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YOAE_ECOLI iep swissprot:YOAE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YOAE_ECOLI inforesidue swissprot:YOAE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YOAE_ECOLI octanol swissprot:YOAE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YOAE_ECOLI pepcoil swissprot:YOAE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YOAE_ECOLI pepdigest swissprot:YOAE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YOAE_ECOLI pepinfo swissprot:YOAE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YOAE_ECOLI pepnet swissprot:YOAE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YOAE_ECOLI pepstats swissprot:YOAE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YOAE_ECOLI pepwheel swissprot:YOAE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YOAE_ECOLI pepwindow swissprot:YOAE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YOAE_ECOLI sigcleave swissprot:YOAE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YOAE_ECOLI ## Database ID URL or Descriptions # AltName YGBM_ECOLI Glyoxylate-induced protein YgbM # BioGrid 4261446 5 # CATALYTIC ACTIVITY YGBM_ECOLI Hydroxypyruvate = 2-hydroxy-3-oxopropanoate. # EcoGene EG13107 ygbM # FUNCTION YGBM_ECOLI Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde). {ECO 0000250}. # GO_function GO:0008903 hydroxypyruvate isomerase activity; IEA:UniProtKB-EC. # GOslim_function GO:0016853 isomerase activity # Gene3D 3.20.20.150 -; 1. # InterPro IPR013022 Xyl_isomerase-like_TIM-brl # InterPro IPR026040 HyI-like # MISCELLANEOUS YGBM_ECOLI Although magnesium ion is present in the structure, it is not required for activity. # Organism YGBM_ECOLI Escherichia coli (strain K12) # PATRIC 32120882 VBIEscCol129921_2833 # PDB 1K77 X-ray; 1.63 A; A=1-258 # PIR G65054 G65054 # PIRSF PIRSF006241 HyI # Pfam PF01261 AP_endonuc_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGBM_ECOLI Putative hydroxypyruvate isomerase YgbM # RefSeq NP_417219 NC_000913.3 # RefSeq WP_001136934 NZ_LN832404.1 # SIMILARITY Belongs to the hyi family. {ECO 0000305}. # SUPFAM SSF51658 SSF51658 # eggNOG COG3622 LUCA # eggNOG ENOG4105QG4 Bacteria BLAST swissprot:YGBM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGBM_ECOLI BioCyc ECOL316407:JW2709-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2709-MONOMER BioCyc EcoCyc:G7420-MONOMER http://biocyc.org/getid?id=EcoCyc:G7420-MONOMER DOI 10.1002/prot.10160 http://dx.doi.org/10.1002/prot.10160 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.3.1.22 http://www.genome.jp/dbget-bin/www_bget?EC:5.3.1.22 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 ENZYME 5.3.1.22 http://enzyme.expasy.org/EC/5.3.1.22 EchoBASE EB2910 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2910 EcoGene EG13107 http://www.ecogene.org/geneInfo.php?eg_id=EG13107 EnsemblBacteria AAC75781 http://www.ensemblgenomes.org/id/AAC75781 EnsemblBacteria AAC75781 http://www.ensemblgenomes.org/id/AAC75781 EnsemblBacteria BAE76816 http://www.ensemblgenomes.org/id/BAE76816 EnsemblBacteria BAE76816 http://www.ensemblgenomes.org/id/BAE76816 EnsemblBacteria BAE76816 http://www.ensemblgenomes.org/id/BAE76816 EnsemblBacteria b2739 http://www.ensemblgenomes.org/id/b2739 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008903 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008903 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 Gene3D 3.20.20.150 http://www.cathdb.info/version/latest/superfamily/3.20.20.150 GeneID 947207 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947207 HOGENOM HOG000218197 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218197&db=HOGENOM6 InParanoid Q46891 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46891 IntAct Q46891 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46891* IntEnz 5.3.1.22 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.3.1.22 InterPro IPR013022 http://www.ebi.ac.uk/interpro/entry/IPR013022 InterPro IPR026040 http://www.ebi.ac.uk/interpro/entry/IPR026040 KEGG_Gene ecj:JW2709 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2709 KEGG_Gene eco:b2739 http://www.genome.jp/dbget-bin/www_bget?eco:b2739 MINT MINT-1286505 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1286505 OMA CANLSFM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CANLSFM PDB 1K77 http://www.ebi.ac.uk/pdbe-srv/view/entry/1K77 PDBsum 1K77 http://www.ebi.ac.uk/pdbsum/1K77 PSORT swissprot:YGBM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGBM_ECOLI PSORT-B swissprot:YGBM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGBM_ECOLI PSORT2 swissprot:YGBM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGBM_ECOLI Pfam PF01261 http://pfam.xfam.org/family/PF01261 Phobius swissprot:YGBM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGBM_ECOLI PhylomeDB Q46891 http://phylomedb.org/?seqid=Q46891 ProteinModelPortal Q46891 http://www.proteinmodelportal.org/query/uniprot/Q46891 PubMed 12112708 http://www.ncbi.nlm.nih.gov/pubmed/12112708 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417219 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417219 RefSeq WP_001136934 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001136934 SMR Q46891 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46891 STRING 511145.b2739 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2739&targetmode=cogs SUPFAM SSF51658 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51658 UniProtKB YGBM_ECOLI http://www.uniprot.org/uniprot/YGBM_ECOLI UniProtKB-AC Q46891 http://www.uniprot.org/uniprot/Q46891 charge swissprot:YGBM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGBM_ECOLI eggNOG COG3622 http://eggnogapi.embl.de/nog_data/html/tree/COG3622 eggNOG ENOG4105QG4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105QG4 epestfind swissprot:YGBM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGBM_ECOLI garnier swissprot:YGBM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGBM_ECOLI helixturnhelix swissprot:YGBM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGBM_ECOLI hmoment swissprot:YGBM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGBM_ECOLI iep swissprot:YGBM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGBM_ECOLI inforesidue swissprot:YGBM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGBM_ECOLI octanol swissprot:YGBM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGBM_ECOLI pepcoil swissprot:YGBM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGBM_ECOLI pepdigest swissprot:YGBM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGBM_ECOLI pepinfo swissprot:YGBM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGBM_ECOLI pepnet swissprot:YGBM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGBM_ECOLI pepstats swissprot:YGBM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGBM_ECOLI pepwheel swissprot:YGBM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGBM_ECOLI pepwindow swissprot:YGBM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGBM_ECOLI sigcleave swissprot:YGBM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGBM_ECOLI ## Database ID URL or Descriptions # AltName BIOH_ECOLI Biotin synthesis protein BioH # AltName BIOH_ECOLI Carboxylesterase BioH # BIOPHYSICOCHEMICAL PROPERTIES BIOH_ECOLI Kinetic parameters KM=229 uM for DMB-S-MMP (at Ph 7.9 and at room temperature) {ECO 0000269|PubMed 12732651, ECO 0000269|PubMed 17625941, ECO 0000269|PubMed 19307763}; KM=0.29 mM for pNP-acetate {ECO 0000269|PubMed 12732651, ECO 0000269|PubMed 17625941, ECO 0000269|PubMed 19307763}; KM=0.35 mM for pNP-propionate {ECO 0000269|PubMed 12732651, ECO 0000269|PubMed 17625941, ECO 0000269|PubMed 19307763}; KM=0.33 mM for pNP-butyrate {ECO 0000269|PubMed 12732651, ECO 0000269|PubMed 17625941, ECO 0000269|PubMed 19307763}; KM=0.25 mM for pNP-caproate {ECO 0000269|PubMed 12732651, ECO 0000269|PubMed 17625941, ECO 0000269|PubMed 19307763}; KM=0.60 mM for pNP-laurate {ECO 0000269|PubMed 12732651, ECO 0000269|PubMed 17625941, ECO 0000269|PubMed 19307763}; Note=The highest catalytic efficiency was observed with pNP- acetate, then with pNP-propionate, pNP-butyrate and pNP- caproate.; pH dependence Optimum pH is 8.0-8.5. The activity is more than 90% in the pH range from 7 to 9. {ECO 0000269|PubMed 12732651, ECO 0000269|PubMed 17625941, ECO 0000269|PubMed 19307763}; Temperature dependence Optimum temperature is between 20 and 30 degrees Celsius. {ECO 0000269|PubMed 12732651, ECO 0000269|PubMed 17625941, ECO 0000269|PubMed 19307763}; # BRENDA 3.1.1 2026 # BRENDA 3.1.1.85 2026 # BioGrid 4263494 14 # CATALYTIC ACTIVITY Pimeloyl-[acyl-carrier protein] methyl ester + H(2)O = pimeloyl-[acyl-carrier protein] + methanol. {ECO:0000269|PubMed 11904168}. # DISRUPTION PHENOTYPE Cells display no detectable hydrolysis of the thioester and no trace of DMB-S-MPA. {ECO:0000269|PubMed 17625941}. # ENZYME REGULATION BIOH_ECOLI Strongly inhibited by phenylmethylsulfonyl fluoride (PMSF). # ESTHER ecoli-bioh BioH # EcoGene EG10122 bioH # FUNCTION BIOH_ECOLI Catalyzes the hydrolysis of the methyl ester bond of dimethylbutyryl-S-methyl mercaptopropionate (DMB-S-MMP) to yield dimethylbutyryl mercaptopropionic acid (DMBS-MPA) during the biocatalytic conversion of simvastin acid from monacolin J acid. Can also use acyl carriers such as dimethylbutyryl-S-ethyl mercaptopropionate (DMB-S-EMP) and dimethylbutyryl-S-methyl thioglycolate (DMB-S-MTG) as the thioester substrates. # FUNCTION BIOH_ECOLI The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters. E.coli employs a methylation and demethylation strategy to allow elongation of a temporarily disguised malonate moiety to a pimelate moiety by the fatty acid synthetic enzymes. BioH shows a preference for short chain fatty acid esters (acyl chain length of up to 6 carbons) and short chain p-nitrophenyl esters. Also displays a weak thioesterase activity. Can form a complex with CoA, and may be involved in the condensation of CoA and pimelic acid into pimeloyl-CoA, a precursor in biotin biosynthesis. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0052689 carboxylic ester hydrolase activity; IDA:UniProtKB. # GO_function GO:0090499 pimelyl-[acyl-carrier protein] methyl ester esterase activity; IDA:EcoCyc. # GO_process GO:0009102 biotin biosynthetic process; IDA:UniProtKB. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.1820 -; 1. # HAMAP MF_01260 Carboxylester # IntAct P13001 4 # InterPro IPR000073 AB_hydrolase_1 # InterPro IPR010076 BioH # InterPro IPR029058 AB_hydrolase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00780 Biotin metabolism # MASS SPECTROMETRY Mass=28502.0; Mass_error=5.5; Method=Electrospray; Range=1-256; Evidence={ECO:0000269|PubMed 11904168}; # Organism BIOH_ECOLI Escherichia coli (strain K12) # PATHWAY BIOH_ECOLI Cofactor biosynthesis; biotin biosynthesis. # PATRIC 32122260 VBIEscCol129921_3507 # PDB 1M33 X-ray; 1.70 A; A=1-256 # PIR JQ0081 BVECBH # Pfam PF00561 Abhydrolase_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BIOH_ECOLI Pimeloyl-[acyl-carrier protein] methyl ester esterase # RefSeq NP_417871 NC_000913.3 # RefSeq WP_001060070 NZ_LN832404.1 # SIMILARITY Belongs to the AB hydrolase superfamily. Carboxylesterase BioH family. {ECO 0000305}. # SIMILARITY Contains 1 AB hydrolase-1 (Alpha/Beta hydrolase fold 1) domain. {ECO 0000255}. # SUBCELLULAR LOCATION BIOH_ECOLI Cytoplasm {ECO 0000250}. # SUBUNIT Monomer. {ECO:0000269|PubMed 11904168}. # SUPFAM SSF53474 SSF53474 # TIGRFAMs TIGR01738 bioH # eggNOG COG0596 LUCA # eggNOG ENOG4105D3C Bacteria BLAST swissprot:BIOH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BIOH_ECOLI BioCyc ECOL316407:JW3375-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3375-MONOMER BioCyc EcoCyc:EG10122-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10122-MONOMER BioCyc MetaCyc:EG10122-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10122-MONOMER COG COG0596 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0596 DIP DIP-9223N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9223N DOI 10.1016/S0014-5793(02)02342-6 http://dx.doi.org/10.1016/S0014-5793(02)02342-6 DOI 10.1016/j.ymben.2007.05.006 http://dx.doi.org/10.1016/j.ymben.2007.05.006 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nchembio.420 http://dx.doi.org/10.1038/nchembio.420 DOI 10.1074/jbc.M303867200 http://dx.doi.org/10.1074/jbc.M303867200 DOI 10.1093/nar/17.19.8004 http://dx.doi.org/10.1093/nar/17.19.8004 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.1.85 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.1.85 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X15587 http://www.ebi.ac.uk/ena/data/view/X15587 ENZYME 3.1.1.85 http://enzyme.expasy.org/EC/3.1.1.85 EchoBASE EB0120 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0120 EcoGene EG10122 http://www.ecogene.org/geneInfo.php?eg_id=EG10122 EnsemblBacteria AAC76437 http://www.ensemblgenomes.org/id/AAC76437 EnsemblBacteria AAC76437 http://www.ensemblgenomes.org/id/AAC76437 EnsemblBacteria BAE77879 http://www.ensemblgenomes.org/id/BAE77879 EnsemblBacteria BAE77879 http://www.ensemblgenomes.org/id/BAE77879 EnsemblBacteria BAE77879 http://www.ensemblgenomes.org/id/BAE77879 EnsemblBacteria b3412 http://www.ensemblgenomes.org/id/b3412 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0052689 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052689 GO_function GO:0090499 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090499 GO_process GO:0009102 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009102 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.1820 http://www.cathdb.info/version/latest/superfamily/3.40.50.1820 GeneID 947916 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947916 HAMAP MF_01260 http://hamap.expasy.org/unirule/MF_01260 HOGENOM HOG000028062 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000028062&db=HOGENOM6 InParanoid P13001 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P13001 IntAct P13001 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P13001* IntEnz 3.1.1.85 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.1.85 InterPro IPR000073 http://www.ebi.ac.uk/interpro/entry/IPR000073 InterPro IPR010076 http://www.ebi.ac.uk/interpro/entry/IPR010076 InterPro IPR029058 http://www.ebi.ac.uk/interpro/entry/IPR029058 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3375 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3375 KEGG_Gene eco:b3412 http://www.genome.jp/dbget-bin/www_bget?eco:b3412 KEGG_Orthology KO:K02170 http://www.genome.jp/dbget-bin/www_bget?KO:K02170 KEGG_Pathway ko00780 http://www.genome.jp/kegg-bin/show_pathway?ko00780 KEGG_Reaction rn:R09725 http://www.genome.jp/dbget-bin/www_bget?rn:R09725 MINT MINT-1253056 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1253056 OMA LICELIS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LICELIS PDB 1M33 http://www.ebi.ac.uk/pdbe-srv/view/entry/1M33 PDBsum 1M33 http://www.ebi.ac.uk/pdbsum/1M33 PSORT swissprot:BIOH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BIOH_ECOLI PSORT-B swissprot:BIOH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BIOH_ECOLI PSORT2 swissprot:BIOH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BIOH_ECOLI Pfam PF00561 http://pfam.xfam.org/family/PF00561 Phobius swissprot:BIOH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BIOH_ECOLI PhylomeDB P13001 http://phylomedb.org/?seqid=P13001 ProteinModelPortal P13001 http://www.proteinmodelportal.org/query/uniprot/P13001 PubMed 11904168 http://www.ncbi.nlm.nih.gov/pubmed/11904168 PubMed 12732651 http://www.ncbi.nlm.nih.gov/pubmed/12732651 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17625941 http://www.ncbi.nlm.nih.gov/pubmed/17625941 PubMed 19307763 http://www.ncbi.nlm.nih.gov/pubmed/19307763 PubMed 20693992 http://www.ncbi.nlm.nih.gov/pubmed/20693992 PubMed 2678009 http://www.ncbi.nlm.nih.gov/pubmed/2678009 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417871 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417871 RefSeq WP_001060070 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001060070 SMR P13001 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P13001 STRING 511145.b3412 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3412&targetmode=cogs STRING COG0596 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0596&targetmode=cogs SUPFAM SSF53474 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53474 TIGRFAMs TIGR01738 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01738 UniProtKB BIOH_ECOLI http://www.uniprot.org/uniprot/BIOH_ECOLI UniProtKB-AC P13001 http://www.uniprot.org/uniprot/P13001 charge swissprot:BIOH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BIOH_ECOLI eggNOG COG0596 http://eggnogapi.embl.de/nog_data/html/tree/COG0596 eggNOG ENOG4105D3C http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D3C epestfind swissprot:BIOH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BIOH_ECOLI garnier swissprot:BIOH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BIOH_ECOLI helixturnhelix swissprot:BIOH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BIOH_ECOLI hmoment swissprot:BIOH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BIOH_ECOLI iep swissprot:BIOH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BIOH_ECOLI inforesidue swissprot:BIOH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BIOH_ECOLI octanol swissprot:BIOH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BIOH_ECOLI pepcoil swissprot:BIOH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BIOH_ECOLI pepdigest swissprot:BIOH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BIOH_ECOLI pepinfo swissprot:BIOH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BIOH_ECOLI pepnet swissprot:BIOH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BIOH_ECOLI pepstats swissprot:BIOH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BIOH_ECOLI pepwheel swissprot:BIOH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BIOH_ECOLI pepwindow swissprot:BIOH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BIOH_ECOLI sigcleave swissprot:BIOH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BIOH_ECOLI ## Database ID URL or Descriptions # BioGrid 4261513 18 # EcoGene EG11607 yciI # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # IntAct P0AB55 7 # InterPro IPR005545 YCII # InterPro IPR011008 Dimeric_a/b-barrel # Organism YCII_ECOLI Escherichia coli (strain K12) # PATRIC 32117762 VBIEscCol129921_1301 # PIR T45506 T45506 # Pfam PF03795 YCII # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCII_ECOLI Protein YciI # RefSeq NP_415767 NC_000913.3 # RefSeq WP_000967595 NZ_LN832404.1 # SIMILARITY Belongs to the YciI family. {ECO 0000305}. # SUBUNIT Homodimer. {ECO 0000250}. # SUPFAM SSF54909 SSF54909 # eggNOG COG2350 LUCA # eggNOG ENOG4105K9H Bacteria BLAST swissprot:YCII_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCII_ECOLI BioCyc ECOL316407:JW1243-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1243-MONOMER BioCyc EcoCyc:EG11607-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11607-MONOMER COG COG2350 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2350 DIP DIP-35954N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35954N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.91.9.3510 http://dx.doi.org/10.1073/pnas.91.9.3510 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1111/j.1574-6968.1998.tb13343.x http://dx.doi.org/10.1111/j.1574-6968.1998.tb13343.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L12044 http://www.ebi.ac.uk/ena/data/view/L12044 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U24195 http://www.ebi.ac.uk/ena/data/view/U24195 EMBL U24196 http://www.ebi.ac.uk/ena/data/view/U24196 EMBL U24197 http://www.ebi.ac.uk/ena/data/view/U24197 EMBL U24198 http://www.ebi.ac.uk/ena/data/view/U24198 EMBL U24199 http://www.ebi.ac.uk/ena/data/view/U24199 EMBL U24200 http://www.ebi.ac.uk/ena/data/view/U24200 EMBL U24201 http://www.ebi.ac.uk/ena/data/view/U24201 EMBL U24202 http://www.ebi.ac.uk/ena/data/view/U24202 EMBL U24203 http://www.ebi.ac.uk/ena/data/view/U24203 EMBL U24204 http://www.ebi.ac.uk/ena/data/view/U24204 EMBL U24205 http://www.ebi.ac.uk/ena/data/view/U24205 EMBL U24206 http://www.ebi.ac.uk/ena/data/view/U24206 EchoBASE EB1564 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1564 EcoGene EG11607 http://www.ecogene.org/geneInfo.php?eg_id=EG11607 EnsemblBacteria AAC74333 http://www.ensemblgenomes.org/id/AAC74333 EnsemblBacteria AAC74333 http://www.ensemblgenomes.org/id/AAC74333 EnsemblBacteria BAA14783 http://www.ensemblgenomes.org/id/BAA14783 EnsemblBacteria BAA14783 http://www.ensemblgenomes.org/id/BAA14783 EnsemblBacteria BAA14783 http://www.ensemblgenomes.org/id/BAA14783 EnsemblBacteria b1251 http://www.ensemblgenomes.org/id/b1251 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GeneID 949085 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949085 HOGENOM HOG000118146 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118146&db=HOGENOM6 InParanoid P0AB55 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AB55 IntAct P0AB55 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AB55* InterPro IPR005545 http://www.ebi.ac.uk/interpro/entry/IPR005545 InterPro IPR011008 http://www.ebi.ac.uk/interpro/entry/IPR011008 KEGG_Gene ecj:JW1243 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1243 KEGG_Gene eco:b1251 http://www.genome.jp/dbget-bin/www_bget?eco:b1251 KEGG_Orthology KO:K09780 http://www.genome.jp/dbget-bin/www_bget?KO:K09780 MINT MINT-1309557 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1309557 OMA MWYMISS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MWYMISS PSORT swissprot:YCII_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCII_ECOLI PSORT-B swissprot:YCII_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCII_ECOLI PSORT2 swissprot:YCII_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCII_ECOLI Pfam PF03795 http://pfam.xfam.org/family/PF03795 Phobius swissprot:YCII_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCII_ECOLI PhylomeDB P0AB55 http://phylomedb.org/?seqid=P0AB55 ProteinModelPortal P0AB55 http://www.proteinmodelportal.org/query/uniprot/P0AB55 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8170937 http://www.ncbi.nlm.nih.gov/pubmed/8170937 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9868784 http://www.ncbi.nlm.nih.gov/pubmed/9868784 RefSeq NP_415767 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415767 RefSeq WP_000967595 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000967595 SMR P0AB55 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AB55 STRING 511145.b1251 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1251&targetmode=cogs STRING COG2350 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2350&targetmode=cogs SUPFAM SSF54909 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54909 SWISS-2DPAGE P0AB55 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AB55 UniProtKB YCII_ECOLI http://www.uniprot.org/uniprot/YCII_ECOLI UniProtKB-AC P0AB55 http://www.uniprot.org/uniprot/P0AB55 charge swissprot:YCII_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCII_ECOLI eggNOG COG2350 http://eggnogapi.embl.de/nog_data/html/tree/COG2350 eggNOG ENOG4105K9H http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K9H epestfind swissprot:YCII_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCII_ECOLI garnier swissprot:YCII_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCII_ECOLI helixturnhelix swissprot:YCII_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCII_ECOLI hmoment swissprot:YCII_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCII_ECOLI iep swissprot:YCII_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCII_ECOLI inforesidue swissprot:YCII_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCII_ECOLI octanol swissprot:YCII_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCII_ECOLI pepcoil swissprot:YCII_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCII_ECOLI pepdigest swissprot:YCII_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCII_ECOLI pepinfo swissprot:YCII_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCII_ECOLI pepnet swissprot:YCII_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCII_ECOLI pepstats swissprot:YCII_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCII_ECOLI pepwheel swissprot:YCII_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCII_ECOLI pepwindow swissprot:YCII_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCII_ECOLI sigcleave swissprot:YCII_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCII_ECOLI ## Database ID URL or Descriptions # AltName Topoisomerase IV subunit A {ECO:0000255|HAMAP-Rule MF_00936} # CATALYTIC ACTIVITY PARC_ECOLI ATP-dependent breakage, passage and rejoining of double-stranded DNA. {ECO 0000255|HAMAP-Rule MF_00936, ECO 0000269|PubMed 12269820, ECO 0000269|PubMed 16023670, ECO 0000269|PubMed 21300644}. # DrugBank DB00817 Rosoxacin # ENZYME REGULATION Inhibited by quinolones. {ECO:0000269|PubMed 12269820}. # EcoGene EG10686 parC # FUNCTION PARC_ECOLI Topoisomerase IV is essential for chromosome segregation; it is the principal protein responsible for decatenating newly replicated chromosomes (PubMed 9334322). It relaxes supercoiled DNA (PubMed 12269820, PuMed 16023670, PubMed 21300644). MukB stimulates the relaxation activity of topoisomerase IV and also has a modest effect on decatenation (PubMed 20921377). {ECO 0000269|PubMed 12269820, ECO 0000269|PubMed 16023670, ECO 0000269|PubMed 20921377, ECO 0000269|PubMed 21300644, ECO 0000269|PubMed 9334322}. # GO_component GO:0005694 chromosome; IEA:InterPro. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0009295 nucleoid; IBA:GO_Central. # GO_component GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing); IDA:EcoliWiki. # GO_component GO:0019897 extrinsic component of plasma membrane; IDA:EcoliWiki. # GO_function GO:0003677 DNA binding; IDA:EcoliWiki. # GO_function GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity; IEA:UniProtKB-HAMAP. # GO_function GO:0005524 ATP binding; IEA:InterPro. # GO_process GO:0006265 DNA topological change; IDA:EcoliWiki. # GO_process GO:0006268 DNA unwinding involved in DNA replication; IBA:GO_Central. # GO_process GO:0007059 chromosome segregation; IDA:EcoliWiki. # GO_process GO:0007062 sister chromatid cohesion; IMP:EcoliWiki. # GO_process GO:0030541 plasmid partitioning; IDA:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005694 chromosome # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0007059 chromosome segregation # GOslim_process GO:0008150 biological_process # GOslim_process GO:0051276 chromosome organization # Gene3D 3.30.1360.40 -; 1. # Gene3D 3.90.199.10 -; 2. # HAMAP MF_00936 ParC_type1 # INTERACTION PARC_ECOLI P22523 mukB; NbExp=7; IntAct=EBI-878544, EBI-542943; # IntAct P0AFI2 23 # InterPro IPR002205 Topo_IIA_A/C # InterPro IPR005742 TopoIV_A_Gneg # InterPro IPR006691 GyrA/parC_pinwhl # InterPro IPR013758 Topo_IIA_A/C_ab # InterPro IPR013760 Topo_IIA-like_dom # InterPro IPR024946 Arg_repress_C-like # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03032 DNA replication proteins # KEGG_Brite ko03036 Chromosome # Organism PARC_ECOLI Escherichia coli (strain K12) # PATRIC 32121452 VBIEscCol129921_3113 # PDB 1ZVT X-ray; 1.70 A; A/B=497-752 # PDB 1ZVU X-ray; 3.00 A; A=27-742 # PDB 4MN4 X-ray; 2.30 A; A/B=497-752 # PIR A65089 A65089 # Pfam PF00521 DNA_topoisoIV # Pfam PF03989 DNA_gyraseA_C; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DNA topoisomerase 4 subunit A {ECO:0000255|HAMAP-Rule MF_00936} # RefSeq NP_417491 NC_000913.3 # RefSeq WP_001281881 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA24297.1; Type=Frameshift; Positions=10; Evidence={ECO 0000305}; # SIMILARITY Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. {ECO:0000255|HAMAP-Rule MF_00936}. # SMART SM00434 TOP4c # SUBCELLULAR LOCATION PARC_ECOLI Cell membrane; Peripheral membrane protein. # SUBUNIT PARC_ECOLI Heterotetramer composed of ParC and ParE. Interacts with MukB. {ECO 0000255|HAMAP-Rule MF_00936, ECO 0000269|PubMed 16023670, ECO 0000269|PubMed 20921377, ECO 0000269|PubMed 21300644, ECO 0000269|PubMed 8227000}. # SUPFAM SSF56719 SSF56719 # eggNOG COG0188 LUCA # eggNOG ENOG4105C24 Bacteria BLAST swissprot:PARC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PARC_ECOLI BioCyc ECOL316407:JW2987-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2987-MONOMER BioCyc EcoCyc:EG10686-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10686-MONOMER COG COG0188 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0188 DIP DIP-36030N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36030N DOI 10.1016/0092-8674(90)90172-B http://dx.doi.org/10.1016/0092-8674(90)90172-B DOI 10.1016/j.jmb.2005.06.029 http://dx.doi.org/10.1016/j.jmb.2005.06.029 DOI 10.1021/bi026352v http://dx.doi.org/10.1021/bi026352v DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.1008678107 http://dx.doi.org/10.1073/pnas.1008678107 DOI 10.1093/nar/gkr018 http://dx.doi.org/10.1093/nar/gkr018 DOI 10.1101/gad.11.19.2580 http://dx.doi.org/10.1101/gad.11.19.2580 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB00817 http://www.drugbank.ca/drugs/DB00817 EC_number EC:5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_00936} http://www.genome.jp/dbget-bin/www_bget?EC:5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_00936} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L22025 http://www.ebi.ac.uk/ena/data/view/L22025 EMBL M58408 http://www.ebi.ac.uk/ena/data/view/M58408 EMBL M63491 http://www.ebi.ac.uk/ena/data/view/M63491 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 ENZYME 5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_00936} http://enzyme.expasy.org/EC/5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_00936} EchoBASE EB0680 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0680 EcoGene EG10686 http://www.ecogene.org/geneInfo.php?eg_id=EG10686 EnsemblBacteria AAC76055 http://www.ensemblgenomes.org/id/AAC76055 EnsemblBacteria AAC76055 http://www.ensemblgenomes.org/id/AAC76055 EnsemblBacteria BAE77075 http://www.ensemblgenomes.org/id/BAE77075 EnsemblBacteria BAE77075 http://www.ensemblgenomes.org/id/BAE77075 EnsemblBacteria BAE77075 http://www.ensemblgenomes.org/id/BAE77075 EnsemblBacteria b3019 http://www.ensemblgenomes.org/id/b3019 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005694 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005694 GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0009295 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009295 GO_component GO:0009330 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009330 GO_component GO:0019897 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019897 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003918 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003918 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006265 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006265 GO_process GO:0006268 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006268 GO_process GO:0007059 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007059 GO_process GO:0007062 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007062 GO_process GO:0030541 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030541 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005694 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005694 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0007059 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007059 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0051276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051276 Gene3D 3.30.1360.40 http://www.cathdb.info/version/latest/superfamily/3.30.1360.40 Gene3D 3.90.199.10 http://www.cathdb.info/version/latest/superfamily/3.90.199.10 GeneID 947499 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947499 HAMAP MF_00936 http://hamap.expasy.org/unirule/MF_00936 HOGENOM HOG000076277 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000076277&db=HOGENOM6 InParanoid P0AFI2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFI2 IntAct P0AFI2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFI2* IntEnz 5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_00936} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.99.1.3 {ECO:0000255|HAMAP-Rule:MF_00936} InterPro IPR002205 http://www.ebi.ac.uk/interpro/entry/IPR002205 InterPro IPR005742 http://www.ebi.ac.uk/interpro/entry/IPR005742 InterPro IPR006691 http://www.ebi.ac.uk/interpro/entry/IPR006691 InterPro IPR013758 http://www.ebi.ac.uk/interpro/entry/IPR013758 InterPro IPR013760 http://www.ebi.ac.uk/interpro/entry/IPR013760 InterPro IPR024946 http://www.ebi.ac.uk/interpro/entry/IPR024946 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03032 http://www.genome.jp/dbget-bin/www_bget?ko03032 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene ecj:JW2987 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2987 KEGG_Gene eco:b3019 http://www.genome.jp/dbget-bin/www_bget?eco:b3019 KEGG_Orthology KO:K02621 http://www.genome.jp/dbget-bin/www_bget?KO:K02621 MINT MINT-1227290 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1227290 OMA RFTEDAY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RFTEDAY PDB 1ZVT http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZVT PDB 1ZVU http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZVU PDB 4MN4 http://www.ebi.ac.uk/pdbe-srv/view/entry/4MN4 PDBsum 1ZVT http://www.ebi.ac.uk/pdbsum/1ZVT PDBsum 1ZVU http://www.ebi.ac.uk/pdbsum/1ZVU PDBsum 4MN4 http://www.ebi.ac.uk/pdbsum/4MN4 PSORT swissprot:PARC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PARC_ECOLI PSORT-B swissprot:PARC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PARC_ECOLI PSORT2 swissprot:PARC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PARC_ECOLI Pfam PF00521 http://pfam.xfam.org/family/PF00521 Pfam PF03989 http://pfam.xfam.org/family/PF03989 Phobius swissprot:PARC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PARC_ECOLI PhylomeDB P0AFI2 http://phylomedb.org/?seqid=P0AFI2 ProteinModelPortal P0AFI2 http://www.proteinmodelportal.org/query/uniprot/P0AFI2 PubMed 12269820 http://www.ncbi.nlm.nih.gov/pubmed/12269820 PubMed 1557036 http://www.ncbi.nlm.nih.gov/pubmed/1557036 PubMed 16023670 http://www.ncbi.nlm.nih.gov/pubmed/16023670 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20921377 http://www.ncbi.nlm.nih.gov/pubmed/20921377 PubMed 21300644 http://www.ncbi.nlm.nih.gov/pubmed/21300644 PubMed 2170028 http://www.ncbi.nlm.nih.gov/pubmed/2170028 PubMed 8227000 http://www.ncbi.nlm.nih.gov/pubmed/8227000 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9334322 http://www.ncbi.nlm.nih.gov/pubmed/9334322 RefSeq NP_417491 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417491 RefSeq WP_001281881 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001281881 SMART SM00434 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00434 SMR P0AFI2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFI2 STRING 511145.b3019 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3019&targetmode=cogs STRING COG0188 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0188&targetmode=cogs SUPFAM SSF56719 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56719 UniProtKB PARC_ECOLI http://www.uniprot.org/uniprot/PARC_ECOLI UniProtKB-AC P0AFI2 http://www.uniprot.org/uniprot/P0AFI2 charge swissprot:PARC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PARC_ECOLI eggNOG COG0188 http://eggnogapi.embl.de/nog_data/html/tree/COG0188 eggNOG ENOG4105C24 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C24 epestfind swissprot:PARC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PARC_ECOLI garnier swissprot:PARC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PARC_ECOLI helixturnhelix swissprot:PARC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PARC_ECOLI hmoment swissprot:PARC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PARC_ECOLI iep swissprot:PARC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PARC_ECOLI inforesidue swissprot:PARC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PARC_ECOLI octanol swissprot:PARC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PARC_ECOLI pepcoil swissprot:PARC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PARC_ECOLI pepdigest swissprot:PARC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PARC_ECOLI pepinfo swissprot:PARC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PARC_ECOLI pepnet swissprot:PARC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PARC_ECOLI pepstats swissprot:PARC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PARC_ECOLI pepwheel swissprot:PARC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PARC_ECOLI pepwindow swissprot:PARC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PARC_ECOLI sigcleave swissprot:PARC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PARC_ECOLI ## Database ID URL or Descriptions # BioGrid 4263231 5 # EcoGene EG10779 pspD # FUNCTION PSPD_ECOLI The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions. {ECO 0000269|PubMed 1712397}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_component GO:0005886 plasma membrane; IDA:EcoliWiki. # GO_process GO:0009271 phage shock; IEP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006950 response to stress # GOslim_process GO:0044403 symbiosis, encompassing mutualism through parasitism # INDUCTION By heat, ethanol, osmotic shock and infection by filamentous bacteriophages. {ECO:0000269|PubMed 1712397}. # InterPro IPR014321 Phageshock_PspD # Organism PSPD_ECOLI Escherichia coli (strain K12) # PATRIC 32117886 VBIEscCol129921_1363 # PIR S17124 S17124 # Pfam PF09584 Phageshock_PspD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PSPD_ECOLI Phage shock protein D # RefSeq NP_415823 NC_000913.3 # RefSeq WP_001295585 NZ_LN832404.1 # SIMILARITY Belongs to the PspD family. {ECO 0000305}. # SUBCELLULAR LOCATION PSPD_ECOLI Cytoplasm {ECO 0000269|PubMed 12562786}. Cell inner membrane {ECO 0000269|PubMed 12562786}; Peripheral membrane protein {ECO 0000269|PubMed 12562786}; Cytoplasmic side {ECO 0000269|PubMed 12562786}. # TIGRFAMs TIGR02979 phageshock_pspD # eggNOG ENOG4105NNG Bacteria # eggNOG ENOG4111WU3 LUCA BLAST swissprot:PSPD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PSPD_ECOLI BioCyc ECOL316407:JW1300-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1300-MONOMER BioCyc EcoCyc:EG10779-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10779-MONOMER DOI 10.1016/0022-2836(91)90379-K http://dx.doi.org/10.1016/0022-2836(91)90379-K DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.185.4.1174-1180.2003 http://dx.doi.org/10.1128/JB.185.4.1174-1180.2003 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X57560 http://www.ebi.ac.uk/ena/data/view/X57560 EchoBASE EB0772 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0772 EcoGene EG10779 http://www.ecogene.org/geneInfo.php?eg_id=EG10779 EnsemblBacteria AAC74389 http://www.ensemblgenomes.org/id/AAC74389 EnsemblBacteria AAC74389 http://www.ensemblgenomes.org/id/AAC74389 EnsemblBacteria BAA14876 http://www.ensemblgenomes.org/id/BAA14876 EnsemblBacteria BAA14876 http://www.ensemblgenomes.org/id/BAA14876 EnsemblBacteria BAA14876 http://www.ensemblgenomes.org/id/BAA14876 EnsemblBacteria b1307 http://www.ensemblgenomes.org/id/b1307 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_process GO:0009271 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009271 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0044403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403 GeneID 945635 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945635 HOGENOM HOG000266569 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000266569&db=HOGENOM6 InParanoid P0AFV8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFV8 InterPro IPR014321 http://www.ebi.ac.uk/interpro/entry/IPR014321 KEGG_Gene ecj:JW1300 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1300 KEGG_Gene eco:b1307 http://www.genome.jp/dbget-bin/www_bget?eco:b1307 KEGG_Orthology KO:K03971 http://www.genome.jp/dbget-bin/www_bget?KO:K03971 OMA MNTVASR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MNTVASR PSORT swissprot:PSPD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PSPD_ECOLI PSORT-B swissprot:PSPD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PSPD_ECOLI PSORT2 swissprot:PSPD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PSPD_ECOLI Pfam PF09584 http://pfam.xfam.org/family/PF09584 Phobius swissprot:PSPD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PSPD_ECOLI ProteinModelPortal P0AFV8 http://www.proteinmodelportal.org/query/uniprot/P0AFV8 PubMed 12562786 http://www.ncbi.nlm.nih.gov/pubmed/12562786 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1712397 http://www.ncbi.nlm.nih.gov/pubmed/1712397 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415823 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415823 RefSeq WP_001295585 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295585 SMR P0AFV8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFV8 STRING 511145.b1307 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1307&targetmode=cogs TIGRFAMs TIGR02979 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02979 UniProtKB PSPD_ECOLI http://www.uniprot.org/uniprot/PSPD_ECOLI UniProtKB-AC P0AFV8 http://www.uniprot.org/uniprot/P0AFV8 charge swissprot:PSPD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PSPD_ECOLI eggNOG ENOG4105NNG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105NNG eggNOG ENOG4111WU3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111WU3 epestfind swissprot:PSPD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PSPD_ECOLI garnier swissprot:PSPD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PSPD_ECOLI helixturnhelix swissprot:PSPD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PSPD_ECOLI hmoment swissprot:PSPD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PSPD_ECOLI iep swissprot:PSPD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PSPD_ECOLI inforesidue swissprot:PSPD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PSPD_ECOLI octanol swissprot:PSPD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PSPD_ECOLI pepcoil swissprot:PSPD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PSPD_ECOLI pepdigest swissprot:PSPD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PSPD_ECOLI pepinfo swissprot:PSPD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PSPD_ECOLI pepnet swissprot:PSPD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PSPD_ECOLI pepstats swissprot:PSPD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PSPD_ECOLI pepwheel swissprot:PSPD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PSPD_ECOLI pepwindow swissprot:PSPD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PSPD_ECOLI sigcleave swissprot:PSPD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PSPD_ECOLI ## Database ID URL or Descriptions # AltName QUEA_ECOLI Queuosine biosynthesis protein QueA # BIOPHYSICOCHEMICAL PROPERTIES QUEA_ECOLI Kinetic parameters KM=98 uM for S-adenosylmethionine {ECO 0000269|PubMed 12731872}; KM=1.9 uM for 7-(aminomethyl)-7-deazaguanosine {ECO 0000269|PubMed 12731872}; # BioGrid 4262056 10 # CATALYTIC ACTIVITY S-adenosyl-L-methionine + 7-aminomethyl-7- carbaguanosine(34) in tRNA = L-methionine + adenine + epoxyqueuosine(34) in tRNA. {ECO:0000269|PubMed 7849103}. # ENZYME REGULATION QUEA_ECOLI Inhibited by S-adenosylhomocysteine, adenosylornithine and products. # EcoGene EG10812 queA # FUNCTION QUEA_ECOLI Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function QUEA_ECOLI GO 0051075 S-adenosylmethionine tRNA ribosyltransferase-isomerase activity; IDA EcoCyc. # GO_process GO:0002099 tRNA wobble guanine modification; IMP:EcoCyc. # GO_process GO:0008616 queuosine biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # HAMAP MF_00113 QueA # IntAct P0A7F9 5 # InterPro IPR003699 QueA # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # MISCELLANEOUS This reaction follows a completely ordered sequential bi-ter kinetic mechanism, with binding of preQ1-tRNATyr followed by AdoMet to form the ternary complex. Products are then released in the following order adenine, methionine, and oQ- tRNATyr. # Organism QUEA_ECOLI Escherichia coli (strain K12) # PATHWAY QUEA_ECOLI tRNA modification; tRNA-queuosine biosynthesis. # PATRIC 32115959 VBIEscCol129921_0421 # PIR B38530 B38530 # Pfam PF02547 Queuosine_synth # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName S-adenosylmethionine tRNA ribosyltransferase-isomerase # RefSeq NP_414939 NC_000913.3 # RefSeq WP_001266503 NZ_LN832404.1 # SIMILARITY Belongs to the QueA family. {ECO 0000305}. # SUBCELLULAR LOCATION QUEA_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT QUEA_ECOLI Monomer. # SUPFAM SSF111337 SSF111337 # TIGRFAMs TIGR00113 queA # eggNOG COG0809 LUCA # eggNOG ENOG4105E2N Bacteria BLAST swissprot:QUEA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:QUEA_ECOLI BioCyc ECOL316407:JW0395-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0395-MONOMER BioCyc EcoCyc:EG10812-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10812-MONOMER BioCyc MetaCyc:EG10812-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10812-MONOMER COG COG0809 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0809 DIP DIP-47972N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47972N DOI 10.1016/0300-9084(94)90113-9 http://dx.doi.org/10.1016/0300-9084(94)90113-9 DOI 10.1021/bi00081a028 http://dx.doi.org/10.1021/bi00081a028 DOI 10.1021/bi034197u http://dx.doi.org/10.1021/bi034197u DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.4.99.17 http://www.genome.jp/dbget-bin/www_bget?EC:2.4.99.17 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M37702 http://www.ebi.ac.uk/ena/data/view/M37702 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 ENZYME 2.4.99.17 http://enzyme.expasy.org/EC/2.4.99.17 EchoBASE EB0805 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0805 EcoGene EG10812 http://www.ecogene.org/geneInfo.php?eg_id=EG10812 EnsemblBacteria AAC73508 http://www.ensemblgenomes.org/id/AAC73508 EnsemblBacteria AAC73508 http://www.ensemblgenomes.org/id/AAC73508 EnsemblBacteria BAE76185 http://www.ensemblgenomes.org/id/BAE76185 EnsemblBacteria BAE76185 http://www.ensemblgenomes.org/id/BAE76185 EnsemblBacteria BAE76185 http://www.ensemblgenomes.org/id/BAE76185 EnsemblBacteria b0405 http://www.ensemblgenomes.org/id/b0405 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0051075 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051075 GO_process GO:0002099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002099 GO_process GO:0008616 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008616 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 944905 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944905 HAMAP MF_00113 http://hamap.expasy.org/unirule/MF_00113 HOGENOM HOG000004401 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000004401&db=HOGENOM6 InParanoid P0A7F9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7F9 IntAct P0A7F9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7F9* IntEnz 2.4.99.17 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.99.17 InterPro IPR003699 http://www.ebi.ac.uk/interpro/entry/IPR003699 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW0395 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0395 KEGG_Gene eco:b0405 http://www.genome.jp/dbget-bin/www_bget?eco:b0405 KEGG_Orthology KO:K07568 http://www.genome.jp/dbget-bin/www_bget?KO:K07568 OMA YGDAMFL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YGDAMFL PSORT swissprot:QUEA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:QUEA_ECOLI PSORT-B swissprot:QUEA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:QUEA_ECOLI PSORT2 swissprot:QUEA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:QUEA_ECOLI Pfam PF02547 http://pfam.xfam.org/family/PF02547 Phobius swissprot:QUEA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:QUEA_ECOLI PhylomeDB P0A7F9 http://phylomedb.org/?seqid=P0A7F9 ProteinModelPortal P0A7F9 http://www.proteinmodelportal.org/query/uniprot/P0A7F9 PubMed 12731872 http://www.ncbi.nlm.nih.gov/pubmed/12731872 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1706703 http://www.ncbi.nlm.nih.gov/pubmed/1706703 PubMed 7849103 http://www.ncbi.nlm.nih.gov/pubmed/7849103 PubMed 8347586 http://www.ncbi.nlm.nih.gov/pubmed/8347586 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414939 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414939 RefSeq WP_001266503 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001266503 SMR P0A7F9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7F9 STRING 511145.b0405 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0405&targetmode=cogs STRING COG0809 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0809&targetmode=cogs SUPFAM SSF111337 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF111337 TIGRFAMs TIGR00113 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00113 UniProtKB QUEA_ECOLI http://www.uniprot.org/uniprot/QUEA_ECOLI UniProtKB-AC P0A7F9 http://www.uniprot.org/uniprot/P0A7F9 charge swissprot:QUEA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:QUEA_ECOLI eggNOG COG0809 http://eggnogapi.embl.de/nog_data/html/tree/COG0809 eggNOG ENOG4105E2N http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E2N epestfind swissprot:QUEA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:QUEA_ECOLI garnier swissprot:QUEA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:QUEA_ECOLI helixturnhelix swissprot:QUEA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:QUEA_ECOLI hmoment swissprot:QUEA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:QUEA_ECOLI iep swissprot:QUEA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:QUEA_ECOLI inforesidue swissprot:QUEA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:QUEA_ECOLI octanol swissprot:QUEA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:QUEA_ECOLI pepcoil swissprot:QUEA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:QUEA_ECOLI pepdigest swissprot:QUEA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:QUEA_ECOLI pepinfo swissprot:QUEA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:QUEA_ECOLI pepnet swissprot:QUEA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:QUEA_ECOLI pepstats swissprot:QUEA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:QUEA_ECOLI pepwheel swissprot:QUEA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:QUEA_ECOLI pepwindow swissprot:QUEA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:QUEA_ECOLI sigcleave swissprot:QUEA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:QUEA_ECOLI ## Database ID URL or Descriptions # FUNCTION INSE7_ECOLI Involved in the transposition of the insertion sequence IS3. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 1.10.10.60 -; 1. # InterPro IPR002514 Transposase_8 # InterPro IPR009057 Homeodomain-like # Organism INSE7_ECOLI Escherichia coli (strain K12) # Pfam PF01527 HTH_Tnp_1 # RecName INSE7_ECOLI Transposase InsE for insertion sequence IS3fB # RefSeq NP_061380 NC_002483.1 # RefSeq NP_061395 NC_002483.1 # RefSeq WP_000169527 NZ_LN832404.1 # SIMILARITY Belongs to the transposase 8 family. {ECO 0000305}. # SUPFAM SSF46689 SSF46689 # eggNOG COG2963 LUCA # eggNOG ENOG41090WB Bacteria BLAST swissprot:INSE7_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSE7_ECOLI EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 GeneID 1263530 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263530 GeneID 1263552 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263552 InterPro IPR002514 http://www.ebi.ac.uk/interpro/entry/IPR002514 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 PSORT swissprot:INSE7_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSE7_ECOLI PSORT-B swissprot:INSE7_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSE7_ECOLI PSORT2 swissprot:INSE7_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSE7_ECOLI Pfam PF01527 http://pfam.xfam.org/family/PF01527 Phobius swissprot:INSE7_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSE7_ECOLI ProteinModelPortal P0CF72 http://www.proteinmodelportal.org/query/uniprot/P0CF72 RefSeq NP_061380 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061380 RefSeq NP_061395 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061395 RefSeq WP_000169527 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000169527 STRING 511145.b2088 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2088&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 UniProtKB INSE7_ECOLI http://www.uniprot.org/uniprot/INSE7_ECOLI UniProtKB-AC P0CF72 http://www.uniprot.org/uniprot/P0CF72 charge swissprot:INSE7_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSE7_ECOLI eggNOG COG2963 http://eggnogapi.embl.de/nog_data/html/tree/COG2963 eggNOG ENOG41090WB http://eggnogapi.embl.de/nog_data/html/tree/ENOG41090WB epestfind swissprot:INSE7_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSE7_ECOLI garnier swissprot:INSE7_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSE7_ECOLI helixturnhelix swissprot:INSE7_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSE7_ECOLI hmoment swissprot:INSE7_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSE7_ECOLI iep swissprot:INSE7_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSE7_ECOLI inforesidue swissprot:INSE7_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSE7_ECOLI octanol swissprot:INSE7_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSE7_ECOLI pepcoil swissprot:INSE7_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSE7_ECOLI pepdigest swissprot:INSE7_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSE7_ECOLI pepinfo swissprot:INSE7_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSE7_ECOLI pepnet swissprot:INSE7_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSE7_ECOLI pepstats swissprot:INSE7_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSE7_ECOLI pepwheel swissprot:INSE7_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSE7_ECOLI pepwindow swissprot:INSE7_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSE7_ECOLI sigcleave swissprot:INSE7_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSE7_ECOLI ## Database ID URL or Descriptions # BioGrid 4260934 29 # EcoGene EG11793 ygdD # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR006696 DUF423 # Organism YGDD_ECOLI Escherichia coli (strain K12) # PATRIC 32121030 VBIEscCol129921_2907 # PIR I41066 I41066 # Pfam PF04241 DUF423 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGDD_ECOLI UPF0382 inner membrane protein YgdD # RefSeq NP_417287 NC_000913.3 # RefSeq WP_000203905 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0382 family. {ECO 0000305}. # SUBCELLULAR LOCATION YGDD_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG COG2363 LUCA # eggNOG ENOG4105M08 Bacteria BLAST swissprot:YGDD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGDD_ECOLI BioCyc ECOL316407:JW2778-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2778-MONOMER BioCyc EcoCyc:EG11793-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11793-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1099/13500872-141-2-419 http://dx.doi.org/10.1099/13500872-141-2-419 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U01030 http://www.ebi.ac.uk/ena/data/view/U01030 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 EMBL X73413 http://www.ebi.ac.uk/ena/data/view/X73413 EchoBASE EB1741 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1741 EcoGene EG11793 http://www.ecogene.org/geneInfo.php?eg_id=EG11793 EnsemblBacteria AAC75849 http://www.ensemblgenomes.org/id/AAC75849 EnsemblBacteria AAC75849 http://www.ensemblgenomes.org/id/AAC75849 EnsemblBacteria BAE76879 http://www.ensemblgenomes.org/id/BAE76879 EnsemblBacteria BAE76879 http://www.ensemblgenomes.org/id/BAE76879 EnsemblBacteria BAE76879 http://www.ensemblgenomes.org/id/BAE76879 EnsemblBacteria b2807 http://www.ensemblgenomes.org/id/b2807 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 947279 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947279 HOGENOM HOG000252654 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000252654&db=HOGENOM6 InParanoid P0ADR2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADR2 InterPro IPR006696 http://www.ebi.ac.uk/interpro/entry/IPR006696 KEGG_Gene ecj:JW2778 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2778 KEGG_Gene eco:b2807 http://www.genome.jp/dbget-bin/www_bget?eco:b2807 OMA ARYQMYH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ARYQMYH PSORT swissprot:YGDD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGDD_ECOLI PSORT-B swissprot:YGDD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGDD_ECOLI PSORT2 swissprot:YGDD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGDD_ECOLI Pfam PF04241 http://pfam.xfam.org/family/PF04241 Phobius swissprot:YGDD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGDD_ECOLI PhylomeDB P0ADR2 http://phylomedb.org/?seqid=P0ADR2 ProteinModelPortal P0ADR2 http://www.proteinmodelportal.org/query/uniprot/P0ADR2 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7704273 http://www.ncbi.nlm.nih.gov/pubmed/7704273 PubMed 8188587 http://www.ncbi.nlm.nih.gov/pubmed/8188587 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417287 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417287 RefSeq WP_000203905 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000203905 STRING 511145.b2807 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2807&targetmode=cogs UniProtKB YGDD_ECOLI http://www.uniprot.org/uniprot/YGDD_ECOLI UniProtKB-AC P0ADR2 http://www.uniprot.org/uniprot/P0ADR2 charge swissprot:YGDD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGDD_ECOLI eggNOG COG2363 http://eggnogapi.embl.de/nog_data/html/tree/COG2363 eggNOG ENOG4105M08 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105M08 epestfind swissprot:YGDD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGDD_ECOLI garnier swissprot:YGDD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGDD_ECOLI helixturnhelix swissprot:YGDD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGDD_ECOLI hmoment swissprot:YGDD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGDD_ECOLI iep swissprot:YGDD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGDD_ECOLI inforesidue swissprot:YGDD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGDD_ECOLI octanol swissprot:YGDD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGDD_ECOLI pepcoil swissprot:YGDD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGDD_ECOLI pepdigest swissprot:YGDD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGDD_ECOLI pepinfo swissprot:YGDD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGDD_ECOLI pepnet swissprot:YGDD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGDD_ECOLI pepstats swissprot:YGDD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGDD_ECOLI pepwheel swissprot:YGDD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGDD_ECOLI pepwindow swissprot:YGDD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGDD_ECOLI sigcleave swissprot:YGDD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGDD_ECOLI ## Database ID URL or Descriptions # BioGrid 4260398 4 # EcoGene EG13378 yeeJ # GO_process GO:0043708 cell adhesion involved in biofilm formation; IMP:EcoCyc. # GOslim_process GO:0007155 cell adhesion # Gene3D 2.60.40.920 -; 16. # Gene3D 3.10.100.10 -; 1. # InterPro IPR003344 Big_1_dom # InterPro IPR003535 Intimin/invasin_bac # InterPro IPR008964 Invasin/intimin_cell_adhesion # InterPro IPR015217 Invasin_dom_3 # InterPro IPR016186 C-type_lectin-like/link # InterPro IPR022409 PKD/Chitinase_dom # InterPro IPR024519 IAT_beta # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko05100 Bacterial invasion of epithelial cells # Organism YEEJ_ECOLI Escherichia coli (strain K12) # PATRIC 32119287 VBIEscCol129921_2056 # PIR D64962 D64962 # PRINTS PR01369 INTIMIN # PROSITE PS51127 BIG1; 13 # PROSITE PS51782 LYSM # Pfam PF02369 Big_1; 13 # Pfam PF09134 Invasin_D3 # Pfam PF11924 IAT_beta # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEEJ_ECOLI Uncharacterized protein YeeJ # RefSeq NP_416485 NC_000913.3 # SIMILARITY Belongs to the intimin/invasin family. {ECO 0000305}. # SIMILARITY Contains 1 LysM domain. {ECO:0000255|PROSITE- ProRule PRU01118}. # SIMILARITY Contains 13 Big-1 (bacterial Ig-like domain 1) domains. {ECO 0000305}. # SMART SM00089 PKD; 4 # SMART SM00634 BID_1; 13 # SUPFAM SSF49373 SSF49373; 16 # eggNOG ENOG4105TNG Bacteria # eggNOG ENOG410XQE6 LUCA BLAST swissprot:YEEJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEEJ_ECOLI BioCyc ECOL316407:JW5833-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5833-MONOMER BioCyc EcoCyc:G7064-MONOMER http://biocyc.org/getid?id=EcoCyc:G7064-MONOMER DIP DIP-28072N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-28072N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3160 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3160 EcoGene EG13378 http://www.ecogene.org/geneInfo.php?eg_id=EG13378 EnsemblBacteria AAC75042 http://www.ensemblgenomes.org/id/AAC75042 EnsemblBacteria AAC75042 http://www.ensemblgenomes.org/id/AAC75042 EnsemblBacteria BAA15800 http://www.ensemblgenomes.org/id/BAA15800 EnsemblBacteria BAA15800 http://www.ensemblgenomes.org/id/BAA15800 EnsemblBacteria BAA15800 http://www.ensemblgenomes.org/id/BAA15800 EnsemblBacteria b1978 http://www.ensemblgenomes.org/id/b1978 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0043708 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043708 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 Gene3D 2.60.40.920 http://www.cathdb.info/version/latest/superfamily/2.60.40.920 Gene3D 3.10.100.10 http://www.cathdb.info/version/latest/superfamily/3.10.100.10 GeneID 946498 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946498 HOGENOM HOG000009505 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009505&db=HOGENOM6 IntAct P76347 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76347* InterPro IPR003344 http://www.ebi.ac.uk/interpro/entry/IPR003344 InterPro IPR003535 http://www.ebi.ac.uk/interpro/entry/IPR003535 InterPro IPR008964 http://www.ebi.ac.uk/interpro/entry/IPR008964 InterPro IPR015217 http://www.ebi.ac.uk/interpro/entry/IPR015217 InterPro IPR016186 http://www.ebi.ac.uk/interpro/entry/IPR016186 InterPro IPR022409 http://www.ebi.ac.uk/interpro/entry/IPR022409 InterPro IPR024519 http://www.ebi.ac.uk/interpro/entry/IPR024519 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW5833 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5833 KEGG_Gene eco:b1978 http://www.genome.jp/dbget-bin/www_bget?eco:b1978 KEGG_Orthology KO:K13735 http://www.genome.jp/dbget-bin/www_bget?KO:K13735 KEGG_Pathway ko05100 http://www.genome.jp/kegg-bin/show_pathway?ko05100 OMA IVNIAPD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IVNIAPD PRINTS PR01369 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01369 PROSITE PS51127 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51127 PROSITE PS51782 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51782 PSORT swissprot:YEEJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEEJ_ECOLI PSORT-B swissprot:YEEJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEEJ_ECOLI PSORT2 swissprot:YEEJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEEJ_ECOLI Pfam PF02369 http://pfam.xfam.org/family/PF02369 Pfam PF09134 http://pfam.xfam.org/family/PF09134 Pfam PF11924 http://pfam.xfam.org/family/PF11924 Phobius swissprot:YEEJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEEJ_ECOLI PhylomeDB P76347 http://phylomedb.org/?seqid=P76347 ProteinModelPortal P76347 http://www.proteinmodelportal.org/query/uniprot/P76347 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416485 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416485 SMART SM00089 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00089 SMART SM00634 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00634 SMR P76347 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76347 STRING 511145.b1978 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1978&targetmode=cogs SUPFAM SSF49373 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49373 UniProtKB YEEJ_ECOLI http://www.uniprot.org/uniprot/YEEJ_ECOLI UniProtKB-AC P76347 http://www.uniprot.org/uniprot/P76347 charge swissprot:YEEJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEEJ_ECOLI eggNOG ENOG4105TNG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105TNG eggNOG ENOG410XQE6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQE6 epestfind swissprot:YEEJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEEJ_ECOLI garnier swissprot:YEEJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEEJ_ECOLI helixturnhelix swissprot:YEEJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEEJ_ECOLI hmoment swissprot:YEEJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEEJ_ECOLI iep swissprot:YEEJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEEJ_ECOLI inforesidue swissprot:YEEJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEEJ_ECOLI octanol swissprot:YEEJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEEJ_ECOLI pepcoil swissprot:YEEJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEEJ_ECOLI pepdigest swissprot:YEEJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEEJ_ECOLI pepinfo swissprot:YEEJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEEJ_ECOLI pepnet swissprot:YEEJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEEJ_ECOLI pepstats swissprot:YEEJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEEJ_ECOLI pepwheel swissprot:YEEJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEEJ_ECOLI pepwindow swissprot:YEEJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEEJ_ECOLI sigcleave swissprot:YEEJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEEJ_ECOLI ## Database ID URL or Descriptions # AltName SELU_ECOLI Selenophosphate-dependent tRNA 2-selenouridine synthase # BIOPHYSICOCHEMICAL PROPERTIES Absorption Abs(max)=258 nm; # BioGrid 4259870 6 # CATALYTIC ACTIVITY SELU_ECOLI 5-methylaminomethyl-2-thiouridine + selenophosphate = 5-methylaminomethyl-2-selenouridine + phosphate. # EcoGene EG11768 selU # FUNCTION SELU_ECOLI Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA. {ECO 0000269|PubMed 14594807}. # GO_function GO:0043828 tRNA 2-selenouridine synthase activity; IDA:EcoCyc. # GO_process GO:0002098 tRNA wobble uridine modification; IMP:EcoCyc. # GO_process GO:0070329 tRNA seleno-modification; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006399 tRNA metabolic process # Gene3D 3.40.250.10 -; 1. # HAMAP MF_01622 tRNA_sel_U_synth # IntAct P33667 2 # InterPro IPR001763 Rhodanese-like_dom # InterPro IPR017582 tRNA_2-selenouridine_synthase # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # Organism SELU_ECOLI Escherichia coli (strain K12) # PATRIC 32116165 VBIEscCol129921_0524 # PIR F64781 F64781 # PROSITE PS50206 RHODANESE_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SELU_ECOLI tRNA 2-selenouridine synthase # RefSeq NP_415036 NC_000913.3 # RefSeq WP_001157938 NZ_LN832404.1 # SIMILARITY Belongs to the 2-selenouridine synthase family. {ECO 0000305}. # SIMILARITY Contains 1 rhodanese domain. {ECO 0000305}. # SMART SM00450 RHOD # SUBUNIT Monomer. {ECO:0000269|PubMed 14594807}. # SUPFAM SSF52821 SSF52821; 2 # TIGRFAMs TIGR03167 tRNA_sel_U_synt # eggNOG COG2603 LUCA # eggNOG ENOG4105CR7 Bacteria BLAST swissprot:SELU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SELU_ECOLI BioCyc ECOL316407:JW0491-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0491-MONOMER BioCyc EcoCyc:EG11768-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11768-MONOMER BioCyc MetaCyc:EG11768-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11768-MONOMER COG COG2603 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2603 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M310442200 http://dx.doi.org/10.1074/jbc.M310442200 DOI 10.1093/nar/19.25.7177 http://dx.doi.org/10.1093/nar/19.25.7177 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.9.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.9.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL X60999 http://www.ebi.ac.uk/ena/data/view/X60999 ENZYME 2.9.1.- http://enzyme.expasy.org/EC/2.9.1.- EchoBASE EB1718 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1718 EcoGene EG11768 http://www.ecogene.org/geneInfo.php?eg_id=EG11768 EnsemblBacteria AAC73605 http://www.ensemblgenomes.org/id/AAC73605 EnsemblBacteria AAC73605 http://www.ensemblgenomes.org/id/AAC73605 EnsemblBacteria BAE76281 http://www.ensemblgenomes.org/id/BAE76281 EnsemblBacteria BAE76281 http://www.ensemblgenomes.org/id/BAE76281 EnsemblBacteria BAE76281 http://www.ensemblgenomes.org/id/BAE76281 EnsemblBacteria b0503 http://www.ensemblgenomes.org/id/b0503 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0043828 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043828 GO_process GO:0002098 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002098 GO_process GO:0070329 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070329 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 Gene3D 3.40.250.10 http://www.cathdb.info/version/latest/superfamily/3.40.250.10 GeneID 947063 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947063 HAMAP MF_01622 http://hamap.expasy.org/unirule/MF_01622 HOGENOM HOG000260000 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260000&db=HOGENOM6 InParanoid P33667 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33667 IntAct P33667 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33667* IntEnz 2.9.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.9.1 InterPro IPR001763 http://www.ebi.ac.uk/interpro/entry/IPR001763 InterPro IPR017582 http://www.ebi.ac.uk/interpro/entry/IPR017582 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW0491 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0491 KEGG_Gene eco:b0503 http://www.genome.jp/dbget-bin/www_bget?eco:b0503 KEGG_Orthology KO:K06917 http://www.genome.jp/dbget-bin/www_bget?KO:K06917 OMA LHRGWIE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LHRGWIE PROSITE PS50206 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50206 PSORT swissprot:SELU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SELU_ECOLI PSORT-B swissprot:SELU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SELU_ECOLI PSORT2 swissprot:SELU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SELU_ECOLI Phobius swissprot:SELU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SELU_ECOLI PhylomeDB P33667 http://phylomedb.org/?seqid=P33667 ProteinModelPortal P33667 http://www.proteinmodelportal.org/query/uniprot/P33667 PubMed 14594807 http://www.ncbi.nlm.nih.gov/pubmed/14594807 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1766878 http://www.ncbi.nlm.nih.gov/pubmed/1766878 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415036 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415036 RefSeq WP_001157938 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001157938 SMART SM00450 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00450 SMR P33667 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33667 STRING 511145.b0503 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0503&targetmode=cogs STRING COG2603 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2603&targetmode=cogs SUPFAM SSF52821 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52821 TIGRFAMs TIGR03167 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03167 UniProtKB SELU_ECOLI http://www.uniprot.org/uniprot/SELU_ECOLI UniProtKB-AC P33667 http://www.uniprot.org/uniprot/P33667 charge swissprot:SELU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SELU_ECOLI eggNOG COG2603 http://eggnogapi.embl.de/nog_data/html/tree/COG2603 eggNOG ENOG4105CR7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CR7 epestfind swissprot:SELU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SELU_ECOLI garnier swissprot:SELU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SELU_ECOLI helixturnhelix swissprot:SELU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SELU_ECOLI hmoment swissprot:SELU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SELU_ECOLI iep swissprot:SELU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SELU_ECOLI inforesidue swissprot:SELU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SELU_ECOLI octanol swissprot:SELU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SELU_ECOLI pepcoil swissprot:SELU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SELU_ECOLI pepdigest swissprot:SELU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SELU_ECOLI pepinfo swissprot:SELU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SELU_ECOLI pepnet swissprot:SELU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SELU_ECOLI pepstats swissprot:SELU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SELU_ECOLI pepwheel swissprot:SELU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SELU_ECOLI pepwindow swissprot:SELU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SELU_ECOLI sigcleave swissprot:SELU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SELU_ECOLI ## Database ID URL or Descriptions # BioGrid 4261196 13 # CAUTION Was originally thought to be a poly(A) polymerase II. {ECO:0000305|PubMed 8876178}. # DOMAIN YIHG_ECOLI The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. {ECO 0000250}. # EcoGene EG11833 yihG # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0016746 transferase activity, transferring acyl groups; IEA:UniProtKB-KW. # GO_process GO:0008152 metabolic process; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0008150 biological_process # INDUCTION In stationary phase. {ECO:0000269|PubMed 8876178}. # InterPro IPR002123 Plipid/glycerol_acylTrfase # Organism YIHG_ECOLI Escherichia coli (strain K12) # PATRIC 32123221 VBIEscCol129921_3971 # PIR S40808 S40808 # Pfam PF01553 Acyltransferase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIHG_ECOLI Probable acyltransferase YihG # RefSeq NP_418299 NC_000913.3 # SIMILARITY Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. {ECO 0000305}. # SMART SM00563 PlsC # SUBCELLULAR LOCATION YIHG_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG COG0204 LUCA # eggNOG ENOG4106HNH Bacteria BLAST swissprot:YIHG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIHG_ECOLI BioCyc ECOL316407:JW3834-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3834-MONOMER BioCyc EcoCyc:EG11833-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11833-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1999.01674.x http://dx.doi.org/10.1046/j.1365-2958.1999.01674.x DOI 10.1073/pnas.93.21.11580 http://dx.doi.org/10.1073/pnas.93.21.11580 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.-.- http://www.genome.jp/dbget-bin/www_bget?EC:2.3.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.3.-.- http://enzyme.expasy.org/EC/2.3.-.- EchoBASE EB1780 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1780 EcoGene EG11833 http://www.ecogene.org/geneInfo.php?eg_id=EG11833 EnsemblBacteria AAC76860 http://www.ensemblgenomes.org/id/AAC76860 EnsemblBacteria AAC76860 http://www.ensemblgenomes.org/id/AAC76860 EnsemblBacteria BAE77446 http://www.ensemblgenomes.org/id/BAE77446 EnsemblBacteria BAE77446 http://www.ensemblgenomes.org/id/BAE77446 EnsemblBacteria BAE77446 http://www.ensemblgenomes.org/id/BAE77446 EnsemblBacteria b3862 http://www.ensemblgenomes.org/id/b3862 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GO_process GO:0008152 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008152 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 948350 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948350 HOGENOM HOG000284917 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000284917&db=HOGENOM6 InParanoid P32129 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32129 IntEnz 2.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3 InterPro IPR002123 http://www.ebi.ac.uk/interpro/entry/IPR002123 KEGG_Gene ecj:JW3834 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3834 KEGG_Gene eco:b3862 http://www.genome.jp/dbget-bin/www_bget?eco:b3862 OMA HHSWADI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HHSWADI PSORT swissprot:YIHG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIHG_ECOLI PSORT-B swissprot:YIHG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIHG_ECOLI PSORT2 swissprot:YIHG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIHG_ECOLI Pfam PF01553 http://pfam.xfam.org/family/PF01553 Phobius swissprot:YIHG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIHG_ECOLI PhylomeDB P32129 http://phylomedb.org/?seqid=P32129 ProteinModelPortal P32129 http://www.proteinmodelportal.org/query/uniprot/P32129 PubMed 10594834 http://www.ncbi.nlm.nih.gov/pubmed/10594834 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 8876178 http://www.ncbi.nlm.nih.gov/pubmed/8876178 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418299 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418299 SMART SM00563 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00563 STRING 511145.b3862 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3862&targetmode=cogs UniProtKB YIHG_ECOLI http://www.uniprot.org/uniprot/YIHG_ECOLI UniProtKB-AC P32129 http://www.uniprot.org/uniprot/P32129 charge swissprot:YIHG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIHG_ECOLI eggNOG COG0204 http://eggnogapi.embl.de/nog_data/html/tree/COG0204 eggNOG ENOG4106HNH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106HNH epestfind swissprot:YIHG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIHG_ECOLI garnier swissprot:YIHG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIHG_ECOLI helixturnhelix swissprot:YIHG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIHG_ECOLI hmoment swissprot:YIHG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIHG_ECOLI iep swissprot:YIHG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIHG_ECOLI inforesidue swissprot:YIHG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIHG_ECOLI octanol swissprot:YIHG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIHG_ECOLI pepcoil swissprot:YIHG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIHG_ECOLI pepdigest swissprot:YIHG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIHG_ECOLI pepinfo swissprot:YIHG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIHG_ECOLI pepnet swissprot:YIHG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIHG_ECOLI pepstats swissprot:YIHG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIHG_ECOLI pepwheel swissprot:YIHG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIHG_ECOLI pepwindow swissprot:YIHG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIHG_ECOLI sigcleave swissprot:YIHG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIHG_ECOLI ## Database ID URL or Descriptions # FUNCTION PIFA_ECOLI Responsible for the exclusion of phage T7 by plasmid F. Growth of bacteriophage T7 is inhibited in cells of E.coli that carries the plasmid F. {ECO 0000269|PubMed 5283385}. # Gene3D 3.40.50.300 -; 2. # InterPro IPR011646 KAP_P-loop # InterPro IPR027417 P-loop_NTPase # Organism PIFA_ECOLI Escherichia coli (strain K12) # Pfam PF07693 KAP_NTPase # RecName PIFA_ECOLI Phage T7 exclusion protein # RefSeq NP_061419 NC_002483.1 # RefSeq WP_000698737 NZ_CP014273.1 # SIMILARITY Contains 1 KAP NTPase domain. {ECO 0000305}. # SUPFAM SSF52540 SSF52540; 2 BLAST swissprot:PIFA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PIFA_ECOLI EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL U89941 http://www.ebi.ac.uk/ena/data/view/U89941 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 1263512 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263512 InterPro IPR011646 http://www.ebi.ac.uk/interpro/entry/IPR011646 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 OMA NPWWFSG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NPWWFSG PSORT swissprot:PIFA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PIFA_ECOLI PSORT-B swissprot:PIFA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PIFA_ECOLI PSORT2 swissprot:PIFA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PIFA_ECOLI Pfam PF07693 http://pfam.xfam.org/family/PF07693 Phobius swissprot:PIFA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PIFA_ECOLI ProteinModelPortal P96329 http://www.proteinmodelportal.org/query/uniprot/P96329 PubMed 5283385 http://www.ncbi.nlm.nih.gov/pubmed/5283385 RefSeq NP_061419 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061419 RefSeq WP_000698737 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000698737 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB PIFA_ECOLI http://www.uniprot.org/uniprot/PIFA_ECOLI UniProtKB-AC P96329 http://www.uniprot.org/uniprot/P96329 charge swissprot:PIFA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PIFA_ECOLI epestfind swissprot:PIFA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PIFA_ECOLI garnier swissprot:PIFA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PIFA_ECOLI helixturnhelix swissprot:PIFA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PIFA_ECOLI hmoment swissprot:PIFA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PIFA_ECOLI iep swissprot:PIFA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PIFA_ECOLI inforesidue swissprot:PIFA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PIFA_ECOLI octanol swissprot:PIFA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PIFA_ECOLI pepcoil swissprot:PIFA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PIFA_ECOLI pepdigest swissprot:PIFA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PIFA_ECOLI pepinfo swissprot:PIFA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PIFA_ECOLI pepnet swissprot:PIFA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PIFA_ECOLI pepstats swissprot:PIFA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PIFA_ECOLI pepwheel swissprot:PIFA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PIFA_ECOLI pepwindow swissprot:PIFA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PIFA_ECOLI sigcleave swissprot:PIFA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PIFA_ECOLI ## Database ID URL or Descriptions # AltName YNFG_ECOLI DMSO reductase iron-sulfur subunit YnfG # BioGrid 4263480 4 # COFACTOR YNFG_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000250}; Note=Binds 4 [4Fe-4S] clusters. {ECO 0000250}; # EcoGene EG13845 ynfG # FUNCTION YNFG_ECOLI Electron transfer subunit of the terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0016491 oxidoreductase activity; IBA:GO_Central. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # InterPro IPR014297 DMSO_DmsB # InterPro IPR017896 4Fe4S_Fe-S-bd # InterPro IPR017900 4Fe4S_Fe_S_CS # KEGG_Brite ko02000 Transporters # Organism YNFG_ECOLI Escherichia coli (strain K12) # PATRIC 32118480 VBIEscCol129921_1660 # PIR G64914 G64914 # PROSITE PS00198 4FE4S_FER_1 # PROSITE PS51379 4FE4S_FER_2; 3 # Pfam PF12800 Fer4_4 # Pfam PF13247 Fer4_11 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNFG_ECOLI Probable anaerobic dimethyl sulfoxide reductase chain YnfG # RefSeq NP_416106 NC_000913.3 # RefSeq WP_000213028 NZ_LN832404.1 # SIMILARITY Contains 3 4Fe-4S ferredoxin-type domains. {ECO:0000255|PROSITE-ProRule PRU00711}. # SUBUNIT The complex consists of three subunits: YnfF, the reductase; YnfG, an electron transfer protein, and YnfH, a membrane anchor protein. {ECO 0000305}. # TCDB 5.A.3.3 the prokaryotic molybdopterin-containing oxidoreductase (pmo) family # TIGRFAMs TIGR02951 DMSO_dmsB # eggNOG COG0437 LUCA # eggNOG ENOG4105QAX Bacteria BLAST swissprot:YNFG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNFG_ECOLI BioCyc ECOL316407:JW1581-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1581-MONOMER BioCyc EcoCyc:G6847-MONOMER http://biocyc.org/getid?id=EcoCyc:G6847-MONOMER BioCyc MetaCyc:G6847-MONOMER http://biocyc.org/getid?id=MetaCyc:G6847-MONOMER COG COG0437 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0437 DIP DIP-48224N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48224N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3606 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3606 EcoGene EG13845 http://www.ecogene.org/geneInfo.php?eg_id=EG13845 EnsemblBacteria AAC74661 http://www.ensemblgenomes.org/id/AAC74661 EnsemblBacteria AAC74661 http://www.ensemblgenomes.org/id/AAC74661 EnsemblBacteria BAA15313 http://www.ensemblgenomes.org/id/BAA15313 EnsemblBacteria BAA15313 http://www.ensemblgenomes.org/id/BAA15313 EnsemblBacteria BAA15313 http://www.ensemblgenomes.org/id/BAA15313 EnsemblBacteria b1589 http://www.ensemblgenomes.org/id/b1589 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GeneID 945638 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945638 HOGENOM HOG000163387 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000163387&db=HOGENOM6 InParanoid P0AAJ1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAJ1 InterPro IPR014297 http://www.ebi.ac.uk/interpro/entry/IPR014297 InterPro IPR017896 http://www.ebi.ac.uk/interpro/entry/IPR017896 InterPro IPR017900 http://www.ebi.ac.uk/interpro/entry/IPR017900 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1581 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1581 KEGG_Gene eco:b1589 http://www.genome.jp/dbget-bin/www_bget?eco:b1589 KEGG_Orthology KO:K07311 http://www.genome.jp/dbget-bin/www_bget?KO:K07311 OMA PGRARIF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PGRARIF PROSITE PS00198 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00198 PROSITE PS51379 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51379 PSORT swissprot:YNFG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNFG_ECOLI PSORT-B swissprot:YNFG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNFG_ECOLI PSORT2 swissprot:YNFG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNFG_ECOLI Pfam PF12800 http://pfam.xfam.org/family/PF12800 Pfam PF13247 http://pfam.xfam.org/family/PF13247 Phobius swissprot:YNFG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNFG_ECOLI PhylomeDB P0AAJ1 http://phylomedb.org/?seqid=P0AAJ1 ProteinModelPortal P0AAJ1 http://www.proteinmodelportal.org/query/uniprot/P0AAJ1 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416106 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416106 RefSeq WP_000213028 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000213028 SMR P0AAJ1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAJ1 STRING 511145.b1589 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1589&targetmode=cogs STRING COG0437 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0437&targetmode=cogs TCDB 5.A.3.3 http://www.tcdb.org/search/result.php?tc=5.A.3.3 TIGRFAMs TIGR02951 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02951 UniProtKB YNFG_ECOLI http://www.uniprot.org/uniprot/YNFG_ECOLI UniProtKB-AC P0AAJ1 http://www.uniprot.org/uniprot/P0AAJ1 charge swissprot:YNFG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNFG_ECOLI eggNOG COG0437 http://eggnogapi.embl.de/nog_data/html/tree/COG0437 eggNOG ENOG4105QAX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105QAX epestfind swissprot:YNFG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNFG_ECOLI garnier swissprot:YNFG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNFG_ECOLI helixturnhelix swissprot:YNFG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNFG_ECOLI hmoment swissprot:YNFG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNFG_ECOLI iep swissprot:YNFG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNFG_ECOLI inforesidue swissprot:YNFG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNFG_ECOLI octanol swissprot:YNFG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNFG_ECOLI pepcoil swissprot:YNFG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNFG_ECOLI pepdigest swissprot:YNFG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNFG_ECOLI pepinfo swissprot:YNFG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNFG_ECOLI pepnet swissprot:YNFG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNFG_ECOLI pepstats swissprot:YNFG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNFG_ECOLI pepwheel swissprot:YNFG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNFG_ECOLI pepwindow swissprot:YNFG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNFG_ECOLI sigcleave swissprot:YNFG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNFG_ECOLI ## Database ID URL or Descriptions # BioGrid 4262571 10 # EcoGene EG11684 yicH # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # InterPro IPR007844 AsmA # Organism YICH_ECOLI Escherichia coli (strain K12) # PATRIC 32122797 VBIEscCol129921_3775 # PIR A65167 A65167 # Pfam PF05170 AsmA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YICH_ECOLI Uncharacterized protein YicH # RefSeq NP_418112 NC_000913.3 # RefSeq WP_001300954 NZ_LN832404.1 # eggNOG ENOG4105JV1 Bacteria # eggNOG ENOG410XTE1 LUCA BLAST swissprot:YICH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YICH_ECOLI BioCyc ECOL316407:JW3630-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3630-MONOMER BioCyc EcoCyc:EG11684-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11684-MONOMER DIP DIP-12432N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12432N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1635 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1635 EcoGene EG11684 http://www.ecogene.org/geneInfo.php?eg_id=EG11684 EnsemblBacteria AAC76679 http://www.ensemblgenomes.org/id/AAC76679 EnsemblBacteria AAC76679 http://www.ensemblgenomes.org/id/AAC76679 EnsemblBacteria BAE77638 http://www.ensemblgenomes.org/id/BAE77638 EnsemblBacteria BAE77638 http://www.ensemblgenomes.org/id/BAE77638 EnsemblBacteria BAE77638 http://www.ensemblgenomes.org/id/BAE77638 EnsemblBacteria b3655 http://www.ensemblgenomes.org/id/b3655 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GeneID 948171 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948171 HOGENOM HOG000126237 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126237&db=HOGENOM6 InParanoid P31433 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31433 InterPro IPR007844 http://www.ebi.ac.uk/interpro/entry/IPR007844 KEGG_Gene ecj:JW3630 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3630 KEGG_Gene eco:b3655 http://www.genome.jp/dbget-bin/www_bget?eco:b3655 OMA QWGIWSG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QWGIWSG PSORT swissprot:YICH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YICH_ECOLI PSORT-B swissprot:YICH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YICH_ECOLI PSORT2 swissprot:YICH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YICH_ECOLI Pfam PF05170 http://pfam.xfam.org/family/PF05170 Phobius swissprot:YICH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YICH_ECOLI ProteinModelPortal P31433 http://www.proteinmodelportal.org/query/uniprot/P31433 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418112 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418112 RefSeq WP_001300954 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300954 STRING 511145.b3655 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3655&targetmode=cogs UniProtKB YICH_ECOLI http://www.uniprot.org/uniprot/YICH_ECOLI UniProtKB-AC P31433 http://www.uniprot.org/uniprot/P31433 charge swissprot:YICH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YICH_ECOLI eggNOG ENOG4105JV1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105JV1 eggNOG ENOG410XTE1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XTE1 epestfind swissprot:YICH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YICH_ECOLI garnier swissprot:YICH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YICH_ECOLI helixturnhelix swissprot:YICH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YICH_ECOLI hmoment swissprot:YICH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YICH_ECOLI iep swissprot:YICH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YICH_ECOLI inforesidue swissprot:YICH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YICH_ECOLI octanol swissprot:YICH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YICH_ECOLI pepcoil swissprot:YICH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YICH_ECOLI pepdigest swissprot:YICH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YICH_ECOLI pepinfo swissprot:YICH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YICH_ECOLI pepnet swissprot:YICH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YICH_ECOLI pepstats swissprot:YICH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YICH_ECOLI pepwheel swissprot:YICH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YICH_ECOLI pepwindow swissprot:YICH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YICH_ECOLI sigcleave swissprot:YICH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YICH_ECOLI ## Database ID URL or Descriptions # BioGrid 4260349 8 # CATALYTIC ACTIVITY CMOB_ECOLI 5-hydroxyuridine(34) in tRNA + carboxy-S- adenosyl-L-methionine = 5-carboxymethoxyuridine(34) in tRNA + S- adenosyl-L-homocysteine. {ECO 0000255|HAMAP-Rule MF_01590, ECO 0000269|PubMed 23676670, ECO 0000269|PubMed 25855808}. # EcoGene EG14034 cmoB # FUNCTION CMOB_ECOLI Catalyzes carboxymethyl transfer from carboxy-S- adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs. Can also catalyze the SAM-dependent methylation of ho5U, with much lower efficiency. {ECO 0000269|PubMed 23676670, ECO 0000269|PubMed 25855808}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0008757 S-adenosylmethionine-dependent methyltransferase activity; IBA:GO_Central. # GO_function GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0002098 tRNA wobble uridine modification; IDA:EcoCyc. # GO_process GO:0032259 methylation; IBA:GO_Central. # GO_process GO:0051289 protein homotetramerization; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008168 methyltransferase activity # GOslim_function GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.150 -; 1. # HAMAP MF_01590 tRNA_carboxymethyltr_CmoB # IntAct P76291 7 # InterPro IPR010017 CmoB # InterPro IPR027555 mo5U34_MeTrfas-like # InterPro IPR029063 SAM-dependent_MTases # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # Organism CMOB_ECOLI Escherichia coli (strain K12) # PATRIC 32119065 VBIEscCol129921_1950 # PDB 4QNU X-ray; 2.60 A; A/B/C/D/E/F/G/H=1-323 # PDB 4QNV X-ray; 2.64 A; A/B=1-323 # PDB 4QNX X-ray; 2.62 A; A/B=1-323 # PIR G64949 G64949 # Pfam PF08003 Methyltransf_9 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName tRNA U34 carboxymethyltransferase {ECO:0000255|HAMAP-Rule MF_01590, ECO:0000305} # RefSeq NP_416385 NC_000913.3 # RefSeq WP_000564725 NZ_LN832404.1 # SIMILARITY Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family. {ECO:0000255|HAMAP- Rule MF_01590, ECO:0000305}. # SUBUNIT CMOB_ECOLI Homotetramer. {ECO 0000255|HAMAP-Rule MF_01590, ECO 0000269|PubMed 25855808}. # SUPFAM SSF53335 SSF53335 # TIGRFAMs TIGR00452 TIGR00452 # eggNOG COG0500 LUCA # eggNOG ENOG4105PFA Bacteria BLAST swissprot:CMOB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CMOB_ECOLI BioCyc ECOL316407:JW1860-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1860-MONOMER BioCyc EcoCyc:G7021-MONOMER http://biocyc.org/getid?id=EcoCyc:G7021-MONOMER BioCyc MetaCyc:G7021-MONOMER http://biocyc.org/getid?id=MetaCyc:G7021-MONOMER COG COG0500 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0500 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature12180 http://dx.doi.org/10.1038/nature12180 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/nar/gkv206 http://dx.doi.org/10.1093/nar/gkv206 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.5.1.- {ECO:0000255|HAMAP-Rule:MF_01590, ECO:0000269|PubMed:23676670, ECO:0000269|PubMed:25855808} http://www.genome.jp/dbget-bin/www_bget?EC:2.5.1.- {ECO:0000255|HAMAP-Rule:MF_01590, ECO:0000269|PubMed:23676670, ECO:0000269|PubMed:25855808} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.5.1.- {ECO:0000255|HAMAP-Rule:MF_01590, ECO:0000269|PubMed:23676670, ECO:0000269|PubMed:25855808} http://enzyme.expasy.org/EC/2.5.1.- {ECO:0000255|HAMAP-Rule:MF_01590, ECO:0000269|PubMed:23676670, ECO:0000269|PubMed:25855808} EchoBASE EB3788 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3788 EcoGene EG14034 http://www.ecogene.org/geneInfo.php?eg_id=EG14034 EnsemblBacteria AAC74941 http://www.ensemblgenomes.org/id/AAC74941 EnsemblBacteria AAC74941 http://www.ensemblgenomes.org/id/AAC74941 EnsemblBacteria BAA15681 http://www.ensemblgenomes.org/id/BAA15681 EnsemblBacteria BAA15681 http://www.ensemblgenomes.org/id/BAA15681 EnsemblBacteria BAA15681 http://www.ensemblgenomes.org/id/BAA15681 EnsemblBacteria b1871 http://www.ensemblgenomes.org/id/b1871 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0008757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008757 GO_function GO:0016765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016765 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0002098 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002098 GO_process GO:0032259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032259 GO_process GO:0051289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051289 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_function GO:0016765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016765 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 GeneID 946387 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946387 HAMAP MF_01590 http://hamap.expasy.org/unirule/MF_01590 HOGENOM HOG000218456 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218456&db=HOGENOM6 InParanoid P76291 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76291 IntAct P76291 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76291* IntEnz 2.5.1.- {ECO:0000255|HAMAP-Rule:MF_01590, ECO:0000269|PubMed:23676670, ECO:0000269|PubMed:25855808} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.5.1.- {ECO:0000255|HAMAP-Rule:MF_01590, ECO:0000269|PubMed:23676670, ECO:0000269|PubMed:25855808} InterPro IPR010017 http://www.ebi.ac.uk/interpro/entry/IPR010017 InterPro IPR027555 http://www.ebi.ac.uk/interpro/entry/IPR027555 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW1860 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1860 KEGG_Gene eco:b1871 http://www.genome.jp/dbget-bin/www_bget?eco:b1871 KEGG_Orthology KO:K15257 http://www.genome.jp/dbget-bin/www_bget?KO:K15257 OMA CEWRSDF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CEWRSDF PDB 4QNU http://www.ebi.ac.uk/pdbe-srv/view/entry/4QNU PDB 4QNV http://www.ebi.ac.uk/pdbe-srv/view/entry/4QNV PDB 4QNX http://www.ebi.ac.uk/pdbe-srv/view/entry/4QNX PDBsum 4QNU http://www.ebi.ac.uk/pdbsum/4QNU PDBsum 4QNV http://www.ebi.ac.uk/pdbsum/4QNV PDBsum 4QNX http://www.ebi.ac.uk/pdbsum/4QNX PSORT swissprot:CMOB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CMOB_ECOLI PSORT-B swissprot:CMOB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CMOB_ECOLI PSORT2 swissprot:CMOB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CMOB_ECOLI Pfam PF08003 http://pfam.xfam.org/family/PF08003 Phobius swissprot:CMOB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CMOB_ECOLI PhylomeDB P76291 http://phylomedb.org/?seqid=P76291 ProteinModelPortal P76291 http://www.proteinmodelportal.org/query/uniprot/P76291 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 23676670 http://www.ncbi.nlm.nih.gov/pubmed/23676670 PubMed 25855808 http://www.ncbi.nlm.nih.gov/pubmed/25855808 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416385 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416385 RefSeq WP_000564725 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000564725 SMR P76291 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76291 STRING 511145.b1871 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1871&targetmode=cogs STRING COG0500 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0500&targetmode=cogs SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 TIGRFAMs TIGR00452 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00452 UniProtKB CMOB_ECOLI http://www.uniprot.org/uniprot/CMOB_ECOLI UniProtKB-AC P76291 http://www.uniprot.org/uniprot/P76291 charge swissprot:CMOB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CMOB_ECOLI eggNOG COG0500 http://eggnogapi.embl.de/nog_data/html/tree/COG0500 eggNOG ENOG4105PFA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105PFA epestfind swissprot:CMOB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CMOB_ECOLI garnier swissprot:CMOB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CMOB_ECOLI helixturnhelix swissprot:CMOB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CMOB_ECOLI hmoment swissprot:CMOB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CMOB_ECOLI iep swissprot:CMOB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CMOB_ECOLI inforesidue swissprot:CMOB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CMOB_ECOLI octanol swissprot:CMOB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CMOB_ECOLI pepcoil swissprot:CMOB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CMOB_ECOLI pepdigest swissprot:CMOB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CMOB_ECOLI pepinfo swissprot:CMOB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CMOB_ECOLI pepnet swissprot:CMOB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CMOB_ECOLI pepstats swissprot:CMOB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CMOB_ECOLI pepwheel swissprot:CMOB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CMOB_ECOLI pepwindow swissprot:CMOB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CMOB_ECOLI sigcleave swissprot:CMOB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CMOB_ECOLI ## Database ID URL or Descriptions # AltName YQEF_ECOLI Acetoacetyl-CoA thiolase # BioGrid 4263512 11 # CATALYTIC ACTIVITY 2 acetyl-CoA = CoA + acetoacetyl-CoA. {ECO:0000255|PROSITE-ProRule PRU10020}. # EcoGene EG13097 yqeF # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003985 acetyl-CoA C-acetyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0003988 acetyl-CoA C-acyltransferase activity; IMP:EcoCyc. # GO_process GO:0006635 fatty acid beta-oxidation; IBA:GO_Central. # GO_process GO:0071271 1-butanol biosynthetic process; IMP:CACAO. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.47.10 -; 4. # InterPro IPR002155 Thiolase # InterPro IPR016039 Thiolase-like # InterPro IPR020610 Thiolase_AS # InterPro IPR020613 Thiolase_CS # InterPro IPR020615 Thiolase_acyl_enz_int_AS # InterPro IPR020616 Thiolase_N # InterPro IPR020617 Thiolase_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00071 Fatty acid metabolism # KEGG_Pathway ko00072 Synthesis and degradation of ketone bodies # KEGG_Pathway ko00280 Valine, leucine and isoleucine degradation # KEGG_Pathway ko00310 Lysine degradation # KEGG_Pathway ko00362 Benzoate degradation # KEGG_Pathway ko00380 Tryptophan metabolism # KEGG_Pathway ko00620 Pyruvate metabolism # KEGG_Pathway ko00630 Glyoxylate and dicarboxylate metabolism # KEGG_Pathway ko00640 Propanoate metabolism # KEGG_Pathway ko00650 Butanoate metabolism # KEGG_Pathway ko00720 Carbon fixation pathways in prokaryotes # KEGG_Pathway ko00900 Terpenoid backbone biosynthesis # KEGG_Pathway ko02020 Two-component system # Organism YQEF_ECOLI Escherichia coli (strain K12) # PATRIC 32121106 VBIEscCol129921_2942 # PIR E65067 E65067 # PIRSF PIRSF000429 Ac-CoA_Ac_transf # PROSITE PS00098 THIOLASE_1 # PROSITE PS00099 THIOLASE_3 # PROSITE PS00737 THIOLASE_2 # Pfam PF00108 Thiolase_N # Pfam PF02803 Thiolase_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQEF_ECOLI Probable acetyl-CoA acetyltransferase # RefSeq NP_417321 NC_000913.3 # RefSeq WP_000656030 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40491.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the thiolase family. {ECO 0000305}. # SUBCELLULAR LOCATION YQEF_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF53901 SSF53901; 2 # TIGRFAMs TIGR01930 AcCoA-C-Actrans # eggNOG COG0183 LUCA # eggNOG ENOG4105CHU Bacteria BLAST swissprot:YQEF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQEF_ECOLI BioCyc ECOL316407:JW5453-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5453-MONOMER BioCyc EcoCyc:G7464-MONOMER http://biocyc.org/getid?id=EcoCyc:G7464-MONOMER COG COG0183 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0183 DIP DIP-12853N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12853N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.9 http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.9 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 ENZYME 2.3.1.9 http://enzyme.expasy.org/EC/2.3.1.9 EchoBASE EB2900 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2900 EcoGene EG13097 http://www.ecogene.org/geneInfo.php?eg_id=EG13097 EnsemblBacteria AAC75883 http://www.ensemblgenomes.org/id/AAC75883 EnsemblBacteria AAC75883 http://www.ensemblgenomes.org/id/AAC75883 EnsemblBacteria BAE76913 http://www.ensemblgenomes.org/id/BAE76913 EnsemblBacteria BAE76913 http://www.ensemblgenomes.org/id/BAE76913 EnsemblBacteria BAE76913 http://www.ensemblgenomes.org/id/BAE76913 EnsemblBacteria b2844 http://www.ensemblgenomes.org/id/b2844 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003985 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003985 GO_function GO:0003988 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003988 GO_process GO:0006635 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006635 GO_process GO:0071271 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071271 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.47.10 http://www.cathdb.info/version/latest/superfamily/3.40.47.10 GeneID 947324 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947324 HOGENOM HOG000012238 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000012238&db=HOGENOM6 InParanoid Q46939 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46939 IntEnz 2.3.1.9 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.9 InterPro IPR002155 http://www.ebi.ac.uk/interpro/entry/IPR002155 InterPro IPR016039 http://www.ebi.ac.uk/interpro/entry/IPR016039 InterPro IPR020610 http://www.ebi.ac.uk/interpro/entry/IPR020610 InterPro IPR020613 http://www.ebi.ac.uk/interpro/entry/IPR020613 InterPro IPR020615 http://www.ebi.ac.uk/interpro/entry/IPR020615 InterPro IPR020616 http://www.ebi.ac.uk/interpro/entry/IPR020616 InterPro IPR020617 http://www.ebi.ac.uk/interpro/entry/IPR020617 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5453 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5453 KEGG_Gene eco:b2844 http://www.genome.jp/dbget-bin/www_bget?eco:b2844 KEGG_Orthology KO:K00626 http://www.genome.jp/dbget-bin/www_bget?KO:K00626 KEGG_Pathway ko00071 http://www.genome.jp/kegg-bin/show_pathway?ko00071 KEGG_Pathway ko00072 http://www.genome.jp/kegg-bin/show_pathway?ko00072 KEGG_Pathway ko00280 http://www.genome.jp/kegg-bin/show_pathway?ko00280 KEGG_Pathway ko00310 http://www.genome.jp/kegg-bin/show_pathway?ko00310 KEGG_Pathway ko00362 http://www.genome.jp/kegg-bin/show_pathway?ko00362 KEGG_Pathway ko00380 http://www.genome.jp/kegg-bin/show_pathway?ko00380 KEGG_Pathway ko00620 http://www.genome.jp/kegg-bin/show_pathway?ko00620 KEGG_Pathway ko00630 http://www.genome.jp/kegg-bin/show_pathway?ko00630 KEGG_Pathway ko00640 http://www.genome.jp/kegg-bin/show_pathway?ko00640 KEGG_Pathway ko00650 http://www.genome.jp/kegg-bin/show_pathway?ko00650 KEGG_Pathway ko00720 http://www.genome.jp/kegg-bin/show_pathway?ko00720 KEGG_Pathway ko00900 http://www.genome.jp/kegg-bin/show_pathway?ko00900 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 KEGG_Reaction rn:R00238 http://www.genome.jp/dbget-bin/www_bget?rn:R00238 KEGG_Reaction rn:R01177 http://www.genome.jp/dbget-bin/www_bget?rn:R01177 OMA ESTEKHN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ESTEKHN PROSITE PS00098 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00098 PROSITE PS00099 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00099 PROSITE PS00737 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00737 PSORT swissprot:YQEF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQEF_ECOLI PSORT-B swissprot:YQEF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQEF_ECOLI PSORT2 swissprot:YQEF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQEF_ECOLI Pfam PF00108 http://pfam.xfam.org/family/PF00108 Pfam PF02803 http://pfam.xfam.org/family/PF02803 Phobius swissprot:YQEF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQEF_ECOLI PhylomeDB Q46939 http://phylomedb.org/?seqid=Q46939 ProteinModelPortal Q46939 http://www.proteinmodelportal.org/query/uniprot/Q46939 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417321 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417321 RefSeq WP_000656030 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000656030 SMR Q46939 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46939 STRING 511145.b2844 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2844&targetmode=cogs STRING COG0183 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0183&targetmode=cogs SUPFAM SSF53901 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53901 TIGRFAMs TIGR01930 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01930 UniProtKB YQEF_ECOLI http://www.uniprot.org/uniprot/YQEF_ECOLI UniProtKB-AC Q46939 http://www.uniprot.org/uniprot/Q46939 charge swissprot:YQEF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQEF_ECOLI eggNOG COG0183 http://eggnogapi.embl.de/nog_data/html/tree/COG0183 eggNOG ENOG4105CHU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CHU epestfind swissprot:YQEF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQEF_ECOLI garnier swissprot:YQEF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQEF_ECOLI helixturnhelix swissprot:YQEF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQEF_ECOLI hmoment swissprot:YQEF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQEF_ECOLI iep swissprot:YQEF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQEF_ECOLI inforesidue swissprot:YQEF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQEF_ECOLI octanol swissprot:YQEF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQEF_ECOLI pepcoil swissprot:YQEF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQEF_ECOLI pepdigest swissprot:YQEF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQEF_ECOLI pepinfo swissprot:YQEF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQEF_ECOLI pepnet swissprot:YQEF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQEF_ECOLI pepstats swissprot:YQEF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQEF_ECOLI pepwheel swissprot:YQEF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQEF_ECOLI pepwindow swissprot:YQEF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQEF_ECOLI sigcleave swissprot:YQEF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQEF_ECOLI ## Database ID URL or Descriptions # BioGrid 4260148 10 # EcoGene EG13921 ycjX # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GOslim_function GO:0043167 ion binding # IntAct P76046 3 # InterPro IPR007413 DUF463_YcjX # Organism YCJX_ECOLI Escherichia coli (strain K12) # PATRIC 32117916 VBIEscCol129921_1378 # PIR D64881 D64881 # PIRSF PIRSF019381 YcjX # Pfam PF04317 DUF463 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCJX_ECOLI Uncharacterized protein YcjX # RefSeq NP_415837 NC_000913.3 # RefSeq WP_000825775 NZ_LN832404.1 # SIMILARITY To H.influenzae HI_1637. {ECO 0000305}. # eggNOG COG3106 LUCA # eggNOG ENOG4105CM6 Bacteria BLAST swissprot:YCJX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCJX_ECOLI BioCyc ECOL316407:JW1314-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1314-MONOMER BioCyc EcoCyc:G6659-MONOMER http://biocyc.org/getid?id=EcoCyc:G6659-MONOMER COG COG3106 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3106 DIP DIP-11615N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11615N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3680 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3680 EcoGene EG13921 http://www.ecogene.org/geneInfo.php?eg_id=EG13921 EnsemblBacteria AAC74403 http://www.ensemblgenomes.org/id/AAC74403 EnsemblBacteria AAC74403 http://www.ensemblgenomes.org/id/AAC74403 EnsemblBacteria BAA14902 http://www.ensemblgenomes.org/id/BAA14902 EnsemblBacteria BAA14902 http://www.ensemblgenomes.org/id/BAA14902 EnsemblBacteria BAA14902 http://www.ensemblgenomes.org/id/BAA14902 EnsemblBacteria b1321 http://www.ensemblgenomes.org/id/b1321 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GeneID 945872 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945872 HOGENOM HOG000276536 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276536&db=HOGENOM6 InParanoid P76046 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76046 IntAct P76046 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76046* InterPro IPR007413 http://www.ebi.ac.uk/interpro/entry/IPR007413 KEGG_Gene ecj:JW1314 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1314 KEGG_Gene eco:b1321 http://www.genome.jp/dbget-bin/www_bget?eco:b1321 KEGG_Orthology KO:K06918 http://www.genome.jp/dbget-bin/www_bget?KO:K06918 OMA FDYPGEW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FDYPGEW PSORT swissprot:YCJX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCJX_ECOLI PSORT-B swissprot:YCJX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCJX_ECOLI PSORT2 swissprot:YCJX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCJX_ECOLI Pfam PF04317 http://pfam.xfam.org/family/PF04317 Phobius swissprot:YCJX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCJX_ECOLI ProteinModelPortal P76046 http://www.proteinmodelportal.org/query/uniprot/P76046 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415837 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415837 RefSeq WP_000825775 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000825775 SMR P76046 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76046 STRING 511145.b1321 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1321&targetmode=cogs STRING COG3106 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3106&targetmode=cogs UniProtKB YCJX_ECOLI http://www.uniprot.org/uniprot/YCJX_ECOLI UniProtKB-AC P76046 http://www.uniprot.org/uniprot/P76046 charge swissprot:YCJX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCJX_ECOLI eggNOG COG3106 http://eggnogapi.embl.de/nog_data/html/tree/COG3106 eggNOG ENOG4105CM6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CM6 epestfind swissprot:YCJX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCJX_ECOLI garnier swissprot:YCJX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCJX_ECOLI helixturnhelix swissprot:YCJX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCJX_ECOLI hmoment swissprot:YCJX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCJX_ECOLI iep swissprot:YCJX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCJX_ECOLI inforesidue swissprot:YCJX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCJX_ECOLI octanol swissprot:YCJX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCJX_ECOLI pepcoil swissprot:YCJX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCJX_ECOLI pepdigest swissprot:YCJX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCJX_ECOLI pepinfo swissprot:YCJX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCJX_ECOLI pepnet swissprot:YCJX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCJX_ECOLI pepstats swissprot:YCJX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCJX_ECOLI pepwheel swissprot:YCJX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCJX_ECOLI pepwindow swissprot:YCJX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCJX_ECOLI sigcleave swissprot:YCJX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCJX_ECOLI ## Database ID URL or Descriptions # BioGrid 4263498 10 # EcoGene EG13688 ybjS # GO_function GO:0003824 catalytic activity; IEA:InterPro. # GO_function GO:0050662 coenzyme binding; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # Gene3D 3.40.50.720 -; 1. # InterPro IPR001509 Epimerase_deHydtase # InterPro IPR016040 NAD(P)-bd_dom # Organism YBJS_ECOLI Escherichia coli (strain K12) # PATRIC 32116943 VBIEscCol129921_0897 # PIR D64825 D64825 # Pfam PF01370 Epimerase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBJS_ECOLI Uncharacterized protein YbjS # RefSeq NP_415389 NC_000913.3 # RefSeq WP_001338420 NZ_LN832404.1 # SIMILARITY Belongs to the NAD(P)-dependent epimerase/dehydratase family. {ECO 0000305}. # SUPFAM SSF51735 SSF51735; 2 # eggNOG COG0451 LUCA # eggNOG ENOG4107VBM Bacteria BLAST swissprot:YBJS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBJS_ECOLI BioCyc ECOL316407:JW5819-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5819-MONOMER BioCyc EcoCyc:G6453-MONOMER http://biocyc.org/getid?id=EcoCyc:G6453-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3452 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3452 EcoGene EG13688 http://www.ecogene.org/geneInfo.php?eg_id=EG13688 EnsemblBacteria AAC73955 http://www.ensemblgenomes.org/id/AAC73955 EnsemblBacteria AAC73955 http://www.ensemblgenomes.org/id/AAC73955 EnsemblBacteria BAA35582 http://www.ensemblgenomes.org/id/BAA35582 EnsemblBacteria BAA35582 http://www.ensemblgenomes.org/id/BAA35582 EnsemblBacteria BAA35582 http://www.ensemblgenomes.org/id/BAA35582 EnsemblBacteria b0868 http://www.ensemblgenomes.org/id/b0868 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003824 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003824 GO_function GO:0050662 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050662 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 945495 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945495 HOGENOM HOG000167989 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000167989&db=HOGENOM6 InParanoid P75821 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75821 InterPro IPR001509 http://www.ebi.ac.uk/interpro/entry/IPR001509 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 KEGG_Gene ecj:JW5819 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5819 KEGG_Gene eco:b0868 http://www.genome.jp/dbget-bin/www_bget?eco:b0868 OMA WGTQEAF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WGTQEAF PSORT swissprot:YBJS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBJS_ECOLI PSORT-B swissprot:YBJS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBJS_ECOLI PSORT2 swissprot:YBJS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBJS_ECOLI Pfam PF01370 http://pfam.xfam.org/family/PF01370 Phobius swissprot:YBJS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBJS_ECOLI PhylomeDB P75821 http://phylomedb.org/?seqid=P75821 ProteinModelPortal P75821 http://www.proteinmodelportal.org/query/uniprot/P75821 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415389 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415389 RefSeq WP_001338420 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001338420 SMR P75821 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75821 STRING 511145.b0868 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0868&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB YBJS_ECOLI http://www.uniprot.org/uniprot/YBJS_ECOLI UniProtKB-AC P75821 http://www.uniprot.org/uniprot/P75821 charge swissprot:YBJS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBJS_ECOLI eggNOG COG0451 http://eggnogapi.embl.de/nog_data/html/tree/COG0451 eggNOG ENOG4107VBM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107VBM epestfind swissprot:YBJS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBJS_ECOLI garnier swissprot:YBJS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBJS_ECOLI helixturnhelix swissprot:YBJS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBJS_ECOLI hmoment swissprot:YBJS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBJS_ECOLI iep swissprot:YBJS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBJS_ECOLI inforesidue swissprot:YBJS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBJS_ECOLI octanol swissprot:YBJS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBJS_ECOLI pepcoil swissprot:YBJS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBJS_ECOLI pepdigest swissprot:YBJS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBJS_ECOLI pepinfo swissprot:YBJS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBJS_ECOLI pepnet swissprot:YBJS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBJS_ECOLI pepstats swissprot:YBJS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBJS_ECOLI pepwheel swissprot:YBJS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBJS_ECOLI pepwindow swissprot:YBJS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBJS_ECOLI sigcleave swissprot:YBJS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBJS_ECOLI ## Database ID URL or Descriptions # AltName THIS_ECOLI Thiamine biosynthesis protein ThiS # BioGrid 4261404 4 # EcoGene EG14363 thiS # FUNCTION THIS_ECOLI Is the sulfur donor in the synthesis of the thiazole phosphate moiety of thiamine phosphate. {ECO 0000269|PubMed 9632726}. # GO_function GO:0000166 nucleotide binding; IEA:UniProtKB-KW. # GO_process GO:0009228 thiamine biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0009229 thiamine diphosphate biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.10.20.30 -; 1. # InterPro IPR003749 ThiS/MoaD # InterPro IPR010035 Thi_S # InterPro IPR012675 Beta-grasp_dom # InterPro IPR016155 Mopterin_synth/thiamin_S_b # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko04122 Sulfur relay system # MASS SPECTROMETRY Mass=7310.74; Method=Electrospray; Range=1-66; Evidence={ECO:0000269|PubMed 10082377}; # MASS SPECTROMETRY Mass=7310.75; Method=Electrospray; Range=1-66; Evidence={ECO:0000269|PubMed 9632726}; # Organism THIS_ECOLI Escherichia coli (strain K12) # PATHWAY THIS_ECOLI Cofactor biosynthesis; thiamine diphosphate biosynthesis. # PATRIC 32123505 VBIEscCol129921_4105 # PDB 1F0Z NMR; -; A=1-66 # PDB 1ZUD X-ray; 1.98 A; 2/4=1-66 # PIR S77700 S77700 # PTM THIS_ECOLI C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) by ThiF, then thiocarboxylated (-COSH) by ThiI. {ECO 0000269|PubMed 9632726}. # Pfam PF02597 ThiS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName THIS_ECOLI Sulfur carrier protein ThiS # RefSeq WP_001166226 NZ_LN832404.1 # RefSeq YP_026279 NC_000913.3 # SIMILARITY Belongs to the sulfur carrier protein ThiS family. {ECO 0000305}. # SUPFAM SSF54285 SSF54285 # TIGRFAMs TIGR01683 thiS # eggNOG COG2104 LUCA # eggNOG ENOG4105WHD Bacteria BLAST swissprot:THIS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:THIS_ECOLI BioCyc ECOL316407:JW3955-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3955-MONOMER BioCyc EcoCyc:THIS-MONOMER http://biocyc.org/getid?id=EcoCyc:THIS-MONOMER BioCyc MetaCyc:THIS-MONOMER http://biocyc.org/getid?id=MetaCyc:THIS-MONOMER COG COG2104 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2104 DOI 10.1002/pro.5560070815 http://dx.doi.org/10.1002/pro.5560070815 DOI 10.1021/bi051502y http://dx.doi.org/10.1021/bi051502y DOI 10.1038/83041 http://dx.doi.org/10.1038/83041 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.141226698 http://dx.doi.org/10.1073/pnas.141226698 DOI 10.1074/jbc.273.26.16555 http://dx.doi.org/10.1074/jbc.273.26.16555 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M88701 http://www.ebi.ac.uk/ena/data/view/M88701 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4108 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4108 EcoGene EG14363 http://www.ecogene.org/geneInfo.php?eg_id=EG14363 EnsemblBacteria AAT48237 http://www.ensemblgenomes.org/id/AAT48237 EnsemblBacteria AAT48237 http://www.ensemblgenomes.org/id/AAT48237 EnsemblBacteria BAE77328 http://www.ensemblgenomes.org/id/BAE77328 EnsemblBacteria BAE77328 http://www.ensemblgenomes.org/id/BAE77328 EnsemblBacteria BAE77328 http://www.ensemblgenomes.org/id/BAE77328 EnsemblBacteria b4407 http://www.ensemblgenomes.org/id/b4407 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000166 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000166 GO_process GO:0009228 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009228 GO_process GO:0009229 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009229 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.10.20.30 http://www.cathdb.info/version/latest/superfamily/3.10.20.30 GeneID 2847702 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2847702 HOGENOM HOG000248060 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000248060&db=HOGENOM6 InParanoid O32583 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=O32583 IntAct O32583 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=O32583* InterPro IPR003749 http://www.ebi.ac.uk/interpro/entry/IPR003749 InterPro IPR010035 http://www.ebi.ac.uk/interpro/entry/IPR010035 InterPro IPR012675 http://www.ebi.ac.uk/interpro/entry/IPR012675 InterPro IPR016155 http://www.ebi.ac.uk/interpro/entry/IPR016155 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW3955 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3955 KEGG_Gene eco:b4407 http://www.genome.jp/dbget-bin/www_bget?eco:b4407 KEGG_Orthology KO:K03154 http://www.genome.jp/dbget-bin/www_bget?KO:K03154 KEGG_Pathway ko04122 http://www.genome.jp/kegg-bin/show_pathway?ko04122 OMA FNDEPLQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FNDEPLQ PDB 1F0Z http://www.ebi.ac.uk/pdbe-srv/view/entry/1F0Z PDB 1ZUD http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZUD PDBsum 1F0Z http://www.ebi.ac.uk/pdbsum/1F0Z PDBsum 1ZUD http://www.ebi.ac.uk/pdbsum/1ZUD PSORT swissprot:THIS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:THIS_ECOLI PSORT-B swissprot:THIS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:THIS_ECOLI PSORT2 swissprot:THIS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:THIS_ECOLI Pfam PF02597 http://pfam.xfam.org/family/PF02597 Phobius swissprot:THIS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:THIS_ECOLI PhylomeDB O32583 http://phylomedb.org/?seqid=O32583 ProteinModelPortal O32583 http://www.proteinmodelportal.org/query/uniprot/O32583 PubMed 10082377 http://www.ncbi.nlm.nih.gov/pubmed/10082377 PubMed 11135670 http://www.ncbi.nlm.nih.gov/pubmed/11135670 PubMed 11438688 http://www.ncbi.nlm.nih.gov/pubmed/11438688 PubMed 16388576 http://www.ncbi.nlm.nih.gov/pubmed/16388576 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 8432721 http://www.ncbi.nlm.nih.gov/pubmed/8432721 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9632726 http://www.ncbi.nlm.nih.gov/pubmed/9632726 RefSeq WP_001166226 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001166226 RefSeq YP_026279 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026279 SMR O32583 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=O32583 STRING 511145.b4407 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4407&targetmode=cogs STRING COG2104 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2104&targetmode=cogs SUPFAM SSF54285 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54285 TIGRFAMs TIGR01683 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01683 UniProtKB THIS_ECOLI http://www.uniprot.org/uniprot/THIS_ECOLI UniProtKB-AC O32583 http://www.uniprot.org/uniprot/O32583 charge swissprot:THIS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:THIS_ECOLI eggNOG COG2104 http://eggnogapi.embl.de/nog_data/html/tree/COG2104 eggNOG ENOG4105WHD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105WHD epestfind swissprot:THIS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:THIS_ECOLI garnier swissprot:THIS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:THIS_ECOLI helixturnhelix swissprot:THIS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:THIS_ECOLI hmoment swissprot:THIS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:THIS_ECOLI iep swissprot:THIS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:THIS_ECOLI inforesidue swissprot:THIS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:THIS_ECOLI octanol swissprot:THIS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:THIS_ECOLI pepcoil swissprot:THIS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:THIS_ECOLI pepdigest swissprot:THIS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:THIS_ECOLI pepinfo swissprot:THIS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:THIS_ECOLI pepnet swissprot:THIS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:THIS_ECOLI pepstats swissprot:THIS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:THIS_ECOLI pepwheel swissprot:THIS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:THIS_ECOLI pepwindow swissprot:THIS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:THIS_ECOLI sigcleave swissprot:THIS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:THIS_ECOLI ## Database ID URL or Descriptions # AltName Fructose-like permease IIC component {ECO:0000305|PubMed 8019415} # AltName Fructose-like phosphotransferase enzyme IIB component {ECO:0000305|PubMed 8019415} # AltName Fructose-like phosphotransferase enzyme IIB component {ECO:0000305|PubMed 8019415} # BioGrid 4259396 16 # CATALYTIC ACTIVITY [Protein]-N(pi)-phospho-L-histidine + D- fructose(Side 1) = [protein]-L-histidine + D-fructose 1- phosphate(Side 2). {ECO:0000250|UniProtKB P20966}. # CDD cd05569 PTS_IIB_fructose # DOMAIN PTFLB_ECOLI The EIIC type-2 domain forms the PTS system translocation channel and contains the specific substrate-binding site. {ECO 0000255|PROSITE-ProRule PRU00427}. # DOMAIN PTFLB_ECOLI The PTS EIIB type-2 domain is phosphorylated by phospho- EIIA on a cysteinyl residue. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the PTS EIIC type-2 domain. {ECO 0000255|PROSITE- ProRule PRU00422}. # EcoGene EG11863 frvB # FUNCTION PTFLB_ECOLI The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FrvAB PTS system is involved in fructose transport. {ECO 0000305|PubMed 8019415}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0016301 kinase activity; IEA:UniProtKB-KW. # GO_function GO:0022877 protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity; IEA:InterPro. # GO_function PTFLB_ECOLI GO 0005351 sugar proton symporter activity; IEA InterPro. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; ISA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR003352 PTS_EIIC # InterPro IPR003353 PTS_IIB_fruc # InterPro IPR003501 PTS_EIIB_2/3 # InterPro IPR006327 PTS_IIC_fruc # InterPro IPR013011 PTS_EIIB_2 # InterPro IPR013014 PTS_EIIC_2 # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00306 PTS system, fructose-specific II-like component # KEGG_Brite ko02000 Transporters # Organism PTFLB_ECOLI Escherichia coli (strain K12) # PATRIC 32123307 VBIEscCol129921_4014 # PROSITE PS51099 PTS_EIIB_TYPE_2 # PROSITE PS51104 PTS_EIIC_TYPE_2 # Pfam PF02302 PTS_IIB # Pfam PF02378 PTS_EIIC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Fructose-like PTS system EIIBC component {ECO:0000305|PubMed 8019415} # RecName Fructose-like PTS system EIIBC component {ECO:0000305|PubMed 8019415} # RecName PTS system fructose-like EIIB component {ECO:0000305|PubMed 8019415} # RecName PTS system fructose-like EIIC component {ECO:0000305|PubMed 8019415} # RefSeq NP_418335 NC_000913.3 # RefSeq WP_000446023 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB03032.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Contains 1 PTS EIIB type-2 domain. {ECO:0000255|PROSITE-ProRule PRU00422}. # SIMILARITY Contains 1 PTS EIIC type-2 domain. {ECO:0000255|PROSITE-ProRule PRU00427}. # SUBCELLULAR LOCATION PTFLB_ECOLI Cell inner membrane {ECO 0000255|PROSITE- ProRule PRU00427, ECO 0000305|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00427}. # SUPFAM SSF52794 SSF52794 # TCDB 4.A.2.1.25 the pts fructose-mannitol (fru) family # TIGRFAMs TIGR00829 FRU # TIGRFAMs TIGR01427 PTS_IIC_fructo # eggNOG COG1299 LUCA # eggNOG COG1445 LUCA # eggNOG ENOG4105DM4 Bacteria BLAST swissprot:PTFLB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTFLB_ECOLI BioCyc ECOL316407:JW5562-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5562-MONOMER BioCyc EcoCyc:FRVB-MONOMER http://biocyc.org/getid?id=EcoCyc:FRVB-MONOMER BioCyc MetaCyc:FRVB-MONOMER http://biocyc.org/getid?id=MetaCyc:FRVB-MONOMER COG COG1299 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1299 DOI 10.1002/pro.5560030309 http://dx.doi.org/10.1002/pro.5560030309 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.202 {ECO:0000250|UniProtKB:P20966} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.202 {ECO:0000250|UniProtKB:P20966} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.202 {ECO:0000250|UniProtKB:P20966} http://enzyme.expasy.org/EC/2.7.1.202 {ECO:0000250|UniProtKB:P20966} EchoBASE EB1809 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1809 EcoGene EG11863 http://www.ecogene.org/geneInfo.php?eg_id=EG11863 EnsemblBacteria AAC76881 http://www.ensemblgenomes.org/id/AAC76881 EnsemblBacteria AAC76881 http://www.ensemblgenomes.org/id/AAC76881 EnsemblBacteria BAE77410 http://www.ensemblgenomes.org/id/BAE77410 EnsemblBacteria BAE77410 http://www.ensemblgenomes.org/id/BAE77410 EnsemblBacteria BAE77410 http://www.ensemblgenomes.org/id/BAE77410 EnsemblBacteria b3899 http://www.ensemblgenomes.org/id/b3899 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005351 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_function GO:0022877 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022877 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948390 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948390 HOGENOM HOG000227677 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000227677&db=HOGENOM6 IntEnz 2.7.1.202 {ECO:0000250|UniProtKB:P20966} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.202 {ECO:0000250|UniProtKB:P20966} InterPro IPR003352 http://www.ebi.ac.uk/interpro/entry/IPR003352 InterPro IPR003353 http://www.ebi.ac.uk/interpro/entry/IPR003353 InterPro IPR003501 http://www.ebi.ac.uk/interpro/entry/IPR003501 InterPro IPR006327 http://www.ebi.ac.uk/interpro/entry/IPR006327 InterPro IPR013011 http://www.ebi.ac.uk/interpro/entry/IPR013011 InterPro IPR013014 http://www.ebi.ac.uk/interpro/entry/IPR013014 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5562 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5562 KEGG_Gene eco:b3899 http://www.genome.jp/dbget-bin/www_bget?eco:b3899 KEGG_Orthology KO:K11203 http://www.genome.jp/dbget-bin/www_bget?KO:K11203 OMA ISTWIRP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ISTWIRP PROSITE PS51099 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51099 PROSITE PS51104 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51104 PSORT swissprot:PTFLB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTFLB_ECOLI PSORT-B swissprot:PTFLB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTFLB_ECOLI PSORT2 swissprot:PTFLB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTFLB_ECOLI Pfam PF02302 http://pfam.xfam.org/family/PF02302 Pfam PF02378 http://pfam.xfam.org/family/PF02378 Phobius swissprot:PTFLB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTFLB_ECOLI PhylomeDB P32154 http://phylomedb.org/?seqid=P32154 ProteinModelPortal P32154 http://www.proteinmodelportal.org/query/uniprot/P32154 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8019415 http://www.ncbi.nlm.nih.gov/pubmed/8019415 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418335 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418335 RefSeq WP_000446023 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000446023 SMR P32154 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32154 STRING 511145.b3899 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3899&targetmode=cogs STRING COG1299 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1299&targetmode=cogs SUPFAM SSF52794 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52794 TCDB 4.A.2.1.25 http://www.tcdb.org/search/result.php?tc=4.A.2.1.25 TIGRFAMs TIGR00829 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00829 TIGRFAMs TIGR01427 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01427 UniProtKB PTFLB_ECOLI http://www.uniprot.org/uniprot/PTFLB_ECOLI UniProtKB-AC P32154 http://www.uniprot.org/uniprot/P32154 charge swissprot:PTFLB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTFLB_ECOLI eggNOG COG1299 http://eggnogapi.embl.de/nog_data/html/tree/COG1299 eggNOG COG1445 http://eggnogapi.embl.de/nog_data/html/tree/COG1445 eggNOG ENOG4105DM4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DM4 epestfind swissprot:PTFLB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTFLB_ECOLI garnier swissprot:PTFLB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTFLB_ECOLI helixturnhelix swissprot:PTFLB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTFLB_ECOLI hmoment swissprot:PTFLB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTFLB_ECOLI iep swissprot:PTFLB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTFLB_ECOLI inforesidue swissprot:PTFLB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTFLB_ECOLI octanol swissprot:PTFLB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTFLB_ECOLI pepcoil swissprot:PTFLB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTFLB_ECOLI pepdigest swissprot:PTFLB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTFLB_ECOLI pepinfo swissprot:PTFLB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTFLB_ECOLI pepnet swissprot:PTFLB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTFLB_ECOLI pepstats swissprot:PTFLB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTFLB_ECOLI pepwheel swissprot:PTFLB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTFLB_ECOLI pepwindow swissprot:PTFLB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTFLB_ECOLI sigcleave swissprot:PTFLB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTFLB_ECOLI ## Database ID URL or Descriptions # BioGrid 4262652 11 # EcoGene EG11903 yijF # InterPro IPR009706 DUF1287 # Organism YIJF_ECOLI Escherichia coli (strain K12) # PATRIC 32123409 VBIEscCol129921_4065 # PIR I78665 I78665 # PIRSF PIRSF011444 DUF1287 # Pfam PF06940 DUF1287 # ProDom PD357862 DUF1287 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIJF_ECOLI Uncharacterized protein YijF # RefSeq NP_418379 NC_000913.3 # RefSeq WP_000647891 NZ_LN832404.1 # eggNOG COG3738 LUCA # eggNOG ENOG4108XC3 Bacteria BLAST swissprot:YIJF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIJF_ECOLI BioCyc ECOL316407:JW3916-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3916-MONOMER BioCyc EcoCyc:EG11903-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11903-MONOMER COG COG3738 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3738 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1848 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1848 EcoGene EG11903 http://www.ecogene.org/geneInfo.php?eg_id=EG11903 EnsemblBacteria AAC76926 http://www.ensemblgenomes.org/id/AAC76926 EnsemblBacteria AAC76926 http://www.ensemblgenomes.org/id/AAC76926 EnsemblBacteria BAE77366 http://www.ensemblgenomes.org/id/BAE77366 EnsemblBacteria BAE77366 http://www.ensemblgenomes.org/id/BAE77366 EnsemblBacteria BAE77366 http://www.ensemblgenomes.org/id/BAE77366 EnsemblBacteria b3944 http://www.ensemblgenomes.org/id/b3944 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 948441 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948441 HOGENOM HOG000010609 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000010609&db=HOGENOM6 InParanoid P32668 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32668 InterPro IPR009706 http://www.ebi.ac.uk/interpro/entry/IPR009706 KEGG_Gene ecj:JW3916 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3916 KEGG_Gene eco:b3944 http://www.genome.jp/dbget-bin/www_bget?eco:b3944 KEGG_Orthology KO:K09974 http://www.genome.jp/dbget-bin/www_bget?KO:K09974 OMA PGNLPHI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PGNLPHI PSORT swissprot:YIJF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIJF_ECOLI PSORT-B swissprot:YIJF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIJF_ECOLI PSORT2 swissprot:YIJF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIJF_ECOLI Pfam PF06940 http://pfam.xfam.org/family/PF06940 Phobius swissprot:YIJF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIJF_ECOLI ProteinModelPortal P32668 http://www.proteinmodelportal.org/query/uniprot/P32668 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418379 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418379 RefSeq WP_000647891 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000647891 STRING 511145.b3944 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3944&targetmode=cogs STRING COG3738 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3738&targetmode=cogs UniProtKB YIJF_ECOLI http://www.uniprot.org/uniprot/YIJF_ECOLI UniProtKB-AC P32668 http://www.uniprot.org/uniprot/P32668 charge swissprot:YIJF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIJF_ECOLI eggNOG COG3738 http://eggnogapi.embl.de/nog_data/html/tree/COG3738 eggNOG ENOG4108XC3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108XC3 epestfind swissprot:YIJF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIJF_ECOLI garnier swissprot:YIJF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIJF_ECOLI helixturnhelix swissprot:YIJF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIJF_ECOLI hmoment swissprot:YIJF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIJF_ECOLI iep swissprot:YIJF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIJF_ECOLI inforesidue swissprot:YIJF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIJF_ECOLI octanol swissprot:YIJF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIJF_ECOLI pepcoil swissprot:YIJF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIJF_ECOLI pepdigest swissprot:YIJF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIJF_ECOLI pepinfo swissprot:YIJF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIJF_ECOLI pepnet swissprot:YIJF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIJF_ECOLI pepstats swissprot:YIJF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIJF_ECOLI pepwheel swissprot:YIJF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIJF_ECOLI pepwindow swissprot:YIJF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIJF_ECOLI sigcleave swissprot:YIJF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIJF_ECOLI ## Database ID URL or Descriptions # BioGrid 4262318 168 # CDD cd00118 LysM # DISRUPTION PHENOTYPE Cells are shorter in a single mutant, while triple envC-nlpD-ygeR disruptions have defects in septation and cell separation and form long filaments (15-fold longer) and further yet by the quadruple disruption mutant (envC-nlpD- mepM(yebA)-ygeR, over 21-fold longer). Quadruple mutants are less sensitive to ampicillin lysis. {ECO:0000269|PubMed 19525345}. # EcoGene EG13048 ygeR # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_process GO:0000920 cell separation after cytokinesis; IGI:EcoliWiki. # GO_process GO:0001896 autolysis; IGI:EcoliWiki. # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0008150 biological_process # GOslim_process GO:0008219 cell death # Gene3D 3.10.350.10 -; 1. # IntAct Q46798 5 # InterPro IPR011055 Dup_hybrid_motif # InterPro IPR016047 Peptidase_M23 # InterPro IPR018392 LysM_dom # Organism YGER_ECOLI Escherichia coli (strain K12) # PATRIC 32121140 VBIEscCol129921_2958 # PIR A65070 A65070 # PROSITE PS51257 PROKAR_LIPOPROTEIN # PROSITE PS51782 LYSM # Pfam PF01476 LysM # Pfam PF01551 Peptidase_M23 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGER_ECOLI Uncharacterized lipoprotein YgeR # RefSeq NP_417341 NC_000913.3 # RefSeq WP_001301085 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA83046.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the peptidase M23B family. {ECO 0000305}. # SIMILARITY Contains 1 LysM domain. {ECO:0000255|PROSITE- ProRule PRU01118}. # SMART SM00257 LysM # SUBCELLULAR LOCATION YGER_ECOLI Cell inner membrane {ECO 0000305}; Lipid- anchor {ECO 0000255|PROSITE-ProRule PRU00303}. Note=Slightly enriched at the septal ring. # SUPFAM SSF51261 SSF51261 # eggNOG COG0739 LUCA # eggNOG ENOG4108K5P Bacteria BLAST swissprot:YGER_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGER_ECOLI BioCyc ECOL316407:JW2833-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2833-MONOMER BioCyc EcoCyc:G7484-MONOMER http://biocyc.org/getid?id=EcoCyc:G7484-MONOMER COG COG0739 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0739 DIP DIP-36034N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36034N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00505-09 http://dx.doi.org/10.1128/JB.00505-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 EchoBASE EB2860 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2860 EcoGene EG13048 http://www.ecogene.org/geneInfo.php?eg_id=EG13048 EnsemblBacteria AAC75903 http://www.ensemblgenomes.org/id/AAC75903 EnsemblBacteria AAC75903 http://www.ensemblgenomes.org/id/AAC75903 EnsemblBacteria BAE76931 http://www.ensemblgenomes.org/id/BAE76931 EnsemblBacteria BAE76931 http://www.ensemblgenomes.org/id/BAE76931 EnsemblBacteria BAE76931 http://www.ensemblgenomes.org/id/BAE76931 EnsemblBacteria b2865 http://www.ensemblgenomes.org/id/b2865 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_process GO:0000920 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000920 GO_process GO:0001896 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001896 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0008219 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008219 Gene3D 3.10.350.10 http://www.cathdb.info/version/latest/superfamily/3.10.350.10 GeneID 947352 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947352 HOGENOM HOG000159026 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000159026&db=HOGENOM6 InParanoid Q46798 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46798 IntAct Q46798 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46798* InterPro IPR011055 http://www.ebi.ac.uk/interpro/entry/IPR011055 InterPro IPR016047 http://www.ebi.ac.uk/interpro/entry/IPR016047 InterPro IPR018392 http://www.ebi.ac.uk/interpro/entry/IPR018392 KEGG_Gene ecj:JW2833 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2833 KEGG_Gene eco:b2865 http://www.genome.jp/dbget-bin/www_bget?eco:b2865 KEGG_Orthology KO:K12943 http://www.genome.jp/dbget-bin/www_bget?KO:K12943 OMA IMIKHGE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IMIKHGE PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PROSITE PS51782 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51782 PSORT swissprot:YGER_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGER_ECOLI PSORT-B swissprot:YGER_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGER_ECOLI PSORT2 swissprot:YGER_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGER_ECOLI Pfam PF01476 http://pfam.xfam.org/family/PF01476 Pfam PF01551 http://pfam.xfam.org/family/PF01551 Phobius swissprot:YGER_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGER_ECOLI PhylomeDB Q46798 http://phylomedb.org/?seqid=Q46798 ProteinModelPortal Q46798 http://www.proteinmodelportal.org/query/uniprot/Q46798 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19525345 http://www.ncbi.nlm.nih.gov/pubmed/19525345 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417341 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417341 RefSeq WP_001301085 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001301085 SMART SM00257 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00257 SMR Q46798 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46798 STRING 511145.b2865 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2865&targetmode=cogs STRING COG0739 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0739&targetmode=cogs SUPFAM SSF51261 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51261 UniProtKB YGER_ECOLI http://www.uniprot.org/uniprot/YGER_ECOLI UniProtKB-AC Q46798 http://www.uniprot.org/uniprot/Q46798 charge swissprot:YGER_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGER_ECOLI eggNOG COG0739 http://eggnogapi.embl.de/nog_data/html/tree/COG0739 eggNOG ENOG4108K5P http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108K5P epestfind swissprot:YGER_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGER_ECOLI garnier swissprot:YGER_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGER_ECOLI helixturnhelix swissprot:YGER_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGER_ECOLI hmoment swissprot:YGER_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGER_ECOLI iep swissprot:YGER_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGER_ECOLI inforesidue swissprot:YGER_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGER_ECOLI octanol swissprot:YGER_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGER_ECOLI pepcoil swissprot:YGER_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGER_ECOLI pepdigest swissprot:YGER_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGER_ECOLI pepinfo swissprot:YGER_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGER_ECOLI pepnet swissprot:YGER_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGER_ECOLI pepstats swissprot:YGER_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGER_ECOLI pepwheel swissprot:YGER_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGER_ECOLI pepwindow swissprot:YGER_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGER_ECOLI sigcleave swissprot:YGER_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGER_ECOLI ## Database ID URL or Descriptions # BioGrid 4259460 15 # EcoGene EG13970 ydiK # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0005215 transporter activity; IBA:GO_Central. # GO_process GO:0055085 transmembrane transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0055085 transmembrane transport # InterPro IPR002549 AI-2E-like # Organism YDIK_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21716 PTHR21716 # PATRIC 32118682 VBIEscCol129921_1759 # PIR H64926 H64926 # Pfam PF01594 AI-2E_transport # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDIK_ECOLI UPF0118 inner membrane protein YdiK # RefSeq NP_416203 NC_000913.3 # RefSeq WP_000248636 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0118 (PerM) family. {ECO 0000305}. # SUBCELLULAR LOCATION YDIK_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG COG0628 LUCA # eggNOG ENOG4105IPI Bacteria BLAST swissprot:YDIK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDIK_ECOLI BioCyc ECOL316407:JW1678-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1678-MONOMER BioCyc EcoCyc:G6914-MONOMER http://biocyc.org/getid?id=EcoCyc:G6914-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3727 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3727 EcoGene EG13970 http://www.ecogene.org/geneInfo.php?eg_id=EG13970 EnsemblBacteria AAC74758 http://www.ensemblgenomes.org/id/AAC74758 EnsemblBacteria AAC74758 http://www.ensemblgenomes.org/id/AAC74758 EnsemblBacteria BAA15450 http://www.ensemblgenomes.org/id/BAA15450 EnsemblBacteria BAA15450 http://www.ensemblgenomes.org/id/BAA15450 EnsemblBacteria BAA15450 http://www.ensemblgenomes.org/id/BAA15450 EnsemblBacteria b1688 http://www.ensemblgenomes.org/id/b1688 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 946183 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946183 HOGENOM HOG000181764 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000181764&db=HOGENOM6 InParanoid P0AFS7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFS7 InterPro IPR002549 http://www.ebi.ac.uk/interpro/entry/IPR002549 KEGG_Gene ecj:JW1678 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1678 KEGG_Gene eco:b1688 http://www.genome.jp/dbget-bin/www_bget?eco:b1688 OMA GFNLADH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GFNLADH PANTHER PTHR21716 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21716 PSORT swissprot:YDIK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDIK_ECOLI PSORT-B swissprot:YDIK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDIK_ECOLI PSORT2 swissprot:YDIK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDIK_ECOLI Pfam PF01594 http://pfam.xfam.org/family/PF01594 Phobius swissprot:YDIK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDIK_ECOLI PhylomeDB P0AFS7 http://phylomedb.org/?seqid=P0AFS7 ProteinModelPortal P0AFS7 http://www.proteinmodelportal.org/query/uniprot/P0AFS7 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416203 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416203 RefSeq WP_000248636 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000248636 STRING 511145.b1688 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1688&targetmode=cogs UniProtKB YDIK_ECOLI http://www.uniprot.org/uniprot/YDIK_ECOLI UniProtKB-AC P0AFS7 http://www.uniprot.org/uniprot/P0AFS7 charge swissprot:YDIK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDIK_ECOLI eggNOG COG0628 http://eggnogapi.embl.de/nog_data/html/tree/COG0628 eggNOG ENOG4105IPI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105IPI epestfind swissprot:YDIK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDIK_ECOLI garnier swissprot:YDIK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDIK_ECOLI helixturnhelix swissprot:YDIK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDIK_ECOLI hmoment swissprot:YDIK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDIK_ECOLI iep swissprot:YDIK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDIK_ECOLI inforesidue swissprot:YDIK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDIK_ECOLI octanol swissprot:YDIK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDIK_ECOLI pepcoil swissprot:YDIK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDIK_ECOLI pepdigest swissprot:YDIK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDIK_ECOLI pepinfo swissprot:YDIK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDIK_ECOLI pepnet swissprot:YDIK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDIK_ECOLI pepstats swissprot:YDIK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDIK_ECOLI pepwheel swissprot:YDIK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDIK_ECOLI pepwindow swissprot:YDIK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDIK_ECOLI sigcleave swissprot:YDIK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDIK_ECOLI ## Database ID URL or Descriptions # AltName GALS_ECOLI Mgl repressor and galactose ultrainduction factor # CDD cd01392 HTH_LacI # EcoGene EG10365 galS # FUNCTION GALS_ECOLI Repressor of the mgl operon. Binds galactose and D- fucose as inducers. GalS binds to an operator DNA sequence within its own coding sequence (corresponding to residues 15 to 20). # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.260.40 -; 1. # INTERACTION GALS_ECOLI P03024 galR; NbExp=5; IntAct=EBI-1117006, EBI-556902; # IntAct P25748 7 # InterPro IPR000843 HTH_LacI # InterPro IPR010982 Lambda_DNA-bd_dom # InterPro IPR028082 Peripla_BP_I # KEGG_Brite ko03000 Transcription factors # Organism GALS_ECOLI Escherichia coli (strain K12) # PATRIC 32119647 VBIEscCol129921_2234 # PIR F64983 F64983 # PRINTS PR00036 HTHLACI # PROSITE PS00356 HTH_LACI_1 # PROSITE PS50932 HTH_LACI_2 # Pfam PF00356 LacI # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GALS_ECOLI HTH-type transcriptional regulator GalS # RefSeq NP_416656 NC_000913.3 # RefSeq WP_000628648 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lacI-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00111}. # SMART SM00354 HTH_LACI # SUBUNIT GALS_ECOLI Homodimer. # SUPFAM SSF47413 SSF47413 # SUPFAM SSF53822 SSF53822 # eggNOG COG1609 LUCA # eggNOG ENOG41060NJ Bacteria BLAST swissprot:GALS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GALS_ECOLI BioCyc ECOL316407:JW2138-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2138-MONOMER BioCyc EcoCyc:PD00261 http://biocyc.org/getid?id=EcoCyc:PD00261 COG COG1609 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1609 DIP DIP-9734N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9734N DOI 10.1016/0022-2836(92)90125-4 http://dx.doi.org/10.1016/0022-2836(92)90125-4 DOI 10.1038/369614a0 http://dx.doi.org/10.1038/369614a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X62529 http://www.ebi.ac.uk/ena/data/view/X62529 EchoBASE EB0360 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0360 EcoGene EG10365 http://www.ecogene.org/geneInfo.php?eg_id=EG10365 EnsemblBacteria AAC75212 http://www.ensemblgenomes.org/id/AAC75212 EnsemblBacteria AAC75212 http://www.ensemblgenomes.org/id/AAC75212 EnsemblBacteria BAE76628 http://www.ensemblgenomes.org/id/BAE76628 EnsemblBacteria BAE76628 http://www.ensemblgenomes.org/id/BAE76628 EnsemblBacteria BAE76628 http://www.ensemblgenomes.org/id/BAE76628 EnsemblBacteria b2151 http://www.ensemblgenomes.org/id/b2151 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.260.40 http://www.cathdb.info/version/latest/superfamily/1.10.260.40 GeneID 949043 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949043 HOGENOM HOG000220179 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220179&db=HOGENOM6 InParanoid P25748 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P25748 IntAct P25748 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P25748* InterPro IPR000843 http://www.ebi.ac.uk/interpro/entry/IPR000843 InterPro IPR010982 http://www.ebi.ac.uk/interpro/entry/IPR010982 InterPro IPR028082 http://www.ebi.ac.uk/interpro/entry/IPR028082 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW2138 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2138 KEGG_Gene eco:b2151 http://www.genome.jp/dbget-bin/www_bget?eco:b2151 KEGG_Orthology KO:K02529 http://www.genome.jp/dbget-bin/www_bget?KO:K02529 OMA IEHAITH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IEHAITH PRINTS PR00036 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00036 PROSITE PS00356 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00356 PROSITE PS50932 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50932 PSORT swissprot:GALS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GALS_ECOLI PSORT-B swissprot:GALS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GALS_ECOLI PSORT2 swissprot:GALS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GALS_ECOLI Pfam PF00356 http://pfam.xfam.org/family/PF00356 Phobius swissprot:GALS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GALS_ECOLI PhylomeDB P25748 http://phylomedb.org/?seqid=P25748 ProteinModelPortal P25748 http://www.proteinmodelportal.org/query/uniprot/P25748 PubMed 1619663 http://www.ncbi.nlm.nih.gov/pubmed/1619663 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8208287 http://www.ncbi.nlm.nih.gov/pubmed/8208287 PubMed 8982002 http://www.ncbi.nlm.nih.gov/pubmed/8982002 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416656 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416656 RefSeq WP_000628648 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000628648 SMART SM00354 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00354 SMR P25748 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P25748 STRING 511145.b2151 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2151&targetmode=cogs STRING COG1609 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1609&targetmode=cogs SUPFAM SSF47413 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47413 SUPFAM SSF53822 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822 UniProtKB GALS_ECOLI http://www.uniprot.org/uniprot/GALS_ECOLI UniProtKB-AC P25748 http://www.uniprot.org/uniprot/P25748 charge swissprot:GALS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GALS_ECOLI eggNOG COG1609 http://eggnogapi.embl.de/nog_data/html/tree/COG1609 eggNOG ENOG41060NJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG41060NJ epestfind swissprot:GALS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GALS_ECOLI garnier swissprot:GALS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GALS_ECOLI helixturnhelix swissprot:GALS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GALS_ECOLI hmoment swissprot:GALS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GALS_ECOLI iep swissprot:GALS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GALS_ECOLI inforesidue swissprot:GALS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GALS_ECOLI octanol swissprot:GALS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GALS_ECOLI pepcoil swissprot:GALS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GALS_ECOLI pepdigest swissprot:GALS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GALS_ECOLI pepinfo swissprot:GALS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GALS_ECOLI pepnet swissprot:GALS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GALS_ECOLI pepstats swissprot:GALS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GALS_ECOLI pepwheel swissprot:GALS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GALS_ECOLI pepwindow swissprot:GALS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GALS_ECOLI sigcleave swissprot:GALS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GALS_ECOLI ## Database ID URL or Descriptions # EcoGene EG12265 bcsG # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR017744 BcsG # MISCELLANEOUS BCSG_ECOLI Cellulose production is abolished in E.coli K12. # Organism BCSG_ECOLI Escherichia coli (strain K12) # PATRIC 32122542 VBIEscCol129921_3649 # PIR S47760 S47760 # Pfam PF11658 CBP_BcsG # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BCSG_ECOLI Protein BcsG homolog # RefSeq NP_417995 NC_000913.3 # RefSeq WP_000191622 NZ_LN832404.1 # SUBCELLULAR LOCATION BCSG_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # TIGRFAMs TIGR03368 cellulose_yhjU # eggNOG ENOG4105D1V Bacteria # eggNOG ENOG410XUV4 LUCA BLAST swissprot:BCSG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BCSG_ECOLI BioCyc ECOL316407:JW3506-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3506-MONOMER BioCyc EcoCyc:EG12265-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12265-MONOMER DIP DIP-12392N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12392N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2174 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2174 EcoGene EG12265 http://www.ecogene.org/geneInfo.php?eg_id=EG12265 EnsemblBacteria AAC76563 http://www.ensemblgenomes.org/id/AAC76563 EnsemblBacteria AAC76563 http://www.ensemblgenomes.org/id/AAC76563 EnsemblBacteria BAE77757 http://www.ensemblgenomes.org/id/BAE77757 EnsemblBacteria BAE77757 http://www.ensemblgenomes.org/id/BAE77757 EnsemblBacteria BAE77757 http://www.ensemblgenomes.org/id/BAE77757 EnsemblBacteria b3538 http://www.ensemblgenomes.org/id/b3538 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 948058 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948058 HOGENOM HOG000259155 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000259155&db=HOGENOM6 IntAct P37659 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37659* InterPro IPR017744 http://www.ebi.ac.uk/interpro/entry/IPR017744 KEGG_Gene ecj:JW3506 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3506 KEGG_Gene eco:b3538 http://www.genome.jp/dbget-bin/www_bget?eco:b3538 MINT MINT-1289882 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1289882 OMA QMSGLRD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QMSGLRD PSORT swissprot:BCSG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BCSG_ECOLI PSORT-B swissprot:BCSG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BCSG_ECOLI PSORT2 swissprot:BCSG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BCSG_ECOLI Pfam PF11658 http://pfam.xfam.org/family/PF11658 Phobius swissprot:BCSG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BCSG_ECOLI ProteinModelPortal P37659 http://www.proteinmodelportal.org/query/uniprot/P37659 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417995 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417995 RefSeq WP_000191622 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000191622 STRING 511145.b3538 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3538&targetmode=cogs TIGRFAMs TIGR03368 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03368 UniProtKB BCSG_ECOLI http://www.uniprot.org/uniprot/BCSG_ECOLI UniProtKB-AC P37659 http://www.uniprot.org/uniprot/P37659 charge swissprot:BCSG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BCSG_ECOLI eggNOG ENOG4105D1V http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D1V eggNOG ENOG410XUV4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XUV4 epestfind swissprot:BCSG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BCSG_ECOLI garnier swissprot:BCSG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BCSG_ECOLI helixturnhelix swissprot:BCSG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BCSG_ECOLI hmoment swissprot:BCSG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BCSG_ECOLI iep swissprot:BCSG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BCSG_ECOLI inforesidue swissprot:BCSG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BCSG_ECOLI octanol swissprot:BCSG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BCSG_ECOLI pepcoil swissprot:BCSG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BCSG_ECOLI pepdigest swissprot:BCSG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BCSG_ECOLI pepinfo swissprot:BCSG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BCSG_ECOLI pepnet swissprot:BCSG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BCSG_ECOLI pepstats swissprot:BCSG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BCSG_ECOLI pepwheel swissprot:BCSG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BCSG_ECOLI pepwindow swissprot:BCSG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BCSG_ECOLI sigcleave swissprot:BCSG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BCSG_ECOLI ## Database ID URL or Descriptions # BioGrid 4260971 12 # EcoGene EG12551 yjhI # GO_function GO:0003677 DNA binding; IBA:GO_Central. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IBA:GO_Central. # GO_process GO:0006351 transcription, DNA-templated; ISS:EcoCyc. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IBA:GO_Central. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # Gene3D 3.30.450.40 -; 1. # IntAct P39360 9 # InterPro IPR005471 Tscrpt_reg_IclR_N # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR014757 Tscrpt_reg_IclR_C # InterPro IPR029016 GAF_dom-like # Organism YJHI_ECOLI Escherichia coli (strain K12) # PATRIC 32124184 VBIEscCol129921_4435 # PIR S56524 S56524 # PROSITE PS51077 HTH_ICLR # PROSITE PS51078 ICLR_ED # Pfam PF01614 IclR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJHI_ECOLI Uncharacterized HTH-type transcriptional regulator YjhI # RefSeq NP_418719 NC_000913.3 # RefSeq WP_000251798 NZ_LN832404.1 # SIMILARITY Contains 1 HTH iclR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00393}. # SIMILARITY Contains 1 iclR-ED (iclR effector binding) domain. {ECO:0000255|PROSITE-ProRule PRU00394}. # SMART SM00346 HTH_ICLR # SUPFAM SSF46785 SSF46785 # SUPFAM SSF55781 SSF55781 # eggNOG ENOG4106P37 Bacteria # eggNOG ENOG410XNU2 LUCA BLAST swissprot:YJHI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJHI_ECOLI BioCyc ECOL316407:JW4261-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4261-MONOMER BioCyc EcoCyc:G7912-MONOMER http://biocyc.org/getid?id=EcoCyc:G7912-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2439 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2439 EcoGene EG12551 http://www.ecogene.org/geneInfo.php?eg_id=EG12551 EnsemblBacteria AAC77255 http://www.ensemblgenomes.org/id/AAC77255 EnsemblBacteria AAC77255 http://www.ensemblgenomes.org/id/AAC77255 EnsemblBacteria BAE78290 http://www.ensemblgenomes.org/id/BAE78290 EnsemblBacteria BAE78290 http://www.ensemblgenomes.org/id/BAE78290 EnsemblBacteria BAE78290 http://www.ensemblgenomes.org/id/BAE78290 EnsemblBacteria b4299 http://www.ensemblgenomes.org/id/b4299 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 3.30.450.40 http://www.cathdb.info/version/latest/superfamily/3.30.450.40 GeneID 949100 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949100 HOGENOM HOG000107041 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000107041&db=HOGENOM6 InParanoid P39360 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39360 IntAct P39360 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39360* InterPro IPR005471 http://www.ebi.ac.uk/interpro/entry/IPR005471 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR014757 http://www.ebi.ac.uk/interpro/entry/IPR014757 InterPro IPR029016 http://www.ebi.ac.uk/interpro/entry/IPR029016 KEGG_Gene ecj:JW4261 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4261 KEGG_Gene eco:b4299 http://www.genome.jp/dbget-bin/www_bget?eco:b4299 OMA MVAPSRD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MVAPSRD PROSITE PS51077 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51077 PROSITE PS51078 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51078 PSORT swissprot:YJHI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJHI_ECOLI PSORT-B swissprot:YJHI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJHI_ECOLI PSORT2 swissprot:YJHI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJHI_ECOLI Pfam PF01614 http://pfam.xfam.org/family/PF01614 Phobius swissprot:YJHI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJHI_ECOLI PhylomeDB P39360 http://phylomedb.org/?seqid=P39360 ProteinModelPortal P39360 http://www.proteinmodelportal.org/query/uniprot/P39360 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418719 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418719 RefSeq WP_000251798 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000251798 SMART SM00346 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00346 SMR P39360 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39360 STRING 511145.b4299 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4299&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SUPFAM SSF55781 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55781 UniProtKB YJHI_ECOLI http://www.uniprot.org/uniprot/YJHI_ECOLI UniProtKB-AC P39360 http://www.uniprot.org/uniprot/P39360 charge swissprot:YJHI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJHI_ECOLI eggNOG ENOG4106P37 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106P37 eggNOG ENOG410XNU2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNU2 epestfind swissprot:YJHI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJHI_ECOLI garnier swissprot:YJHI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJHI_ECOLI helixturnhelix swissprot:YJHI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJHI_ECOLI hmoment swissprot:YJHI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJHI_ECOLI iep swissprot:YJHI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJHI_ECOLI inforesidue swissprot:YJHI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJHI_ECOLI octanol swissprot:YJHI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJHI_ECOLI pepcoil swissprot:YJHI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJHI_ECOLI pepdigest swissprot:YJHI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJHI_ECOLI pepinfo swissprot:YJHI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJHI_ECOLI pepnet swissprot:YJHI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJHI_ECOLI pepstats swissprot:YJHI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJHI_ECOLI pepwheel swissprot:YJHI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJHI_ECOLI pepwindow swissprot:YJHI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJHI_ECOLI sigcleave swissprot:YJHI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJHI_ECOLI ## Database ID URL or Descriptions # AltName RLMG_ECOLI 23S rRNA m2G1835 methyltransferase # AltName RLMG_ECOLI rRNA (guanine-N(2)-)-methyltransferase RlmG # BRENDA 2.1.1.174 2026 # BioGrid 4260876 18 # CATALYTIC ACTIVITY RLMG_ECOLI S-adenosyl-L-methionine + guanine(1835) in 23S rRNA = S-adenosyl-L-homocysteine + N(2)-methylguanine(1835) in 23S rRNA. # EcoGene EG12726 rlmG # FUNCTION RLMG_ECOLI Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA. {ECO 0000269|PubMed 17010380}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003676 nucleic acid binding; IEA:InterPro. # GO_function GO:0052916 23S rRNA (guanine(1835)-N(2))-methyltransferase activity; IDA:EcoCyc. # GO_process GO:0070475 rRNA base methylation; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.50.150 -; 1. # HAMAP MF_01859 23SrRNA_methyltr_G # InterPro IPR002052 DNA_methylase_N6_adenine_CS # InterPro IPR007848 Small_mtfrase_dom # InterPro IPR017237 rRNA_m2G-MeTrfase_RsmD # InterPro IPR029063 SAM-dependent_MTases # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # Organism RLMG_ECOLI Escherichia coli (strain K12) # PATRIC 32121586 VBIEscCol129921_3179 # PDB 4DCM X-ray; 2.30 A; A=9-373 # PIR A65097 A65097 # PIRSF PIRSF037565 RRNA_m2G_Mtase_RsmD_prd # Pfam PF05175 MTS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RLMG_ECOLI Ribosomal RNA large subunit methyltransferase G # RefSeq NP_417555 NC_000913.3 # RefSeq WP_000018695 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA57885.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the methyltransferase superfamily. RlmG family. {ECO 0000305}. # SUBCELLULAR LOCATION RLMG_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF53335 SSF53335 # eggNOG COG2813 LUCA # eggNOG ENOG4105D8J Bacteria BLAST swissprot:RLMG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RLMG_ECOLI BioCyc ECOL316407:JW5513-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5513-MONOMER BioCyc EcoCyc:G7603-MONOMER http://biocyc.org/getid?id=EcoCyc:G7603-MONOMER BioCyc MetaCyc:G7603-MONOMER http://biocyc.org/getid?id=MetaCyc:G7603-MONOMER COG COG2813 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2813 DOI 10.1016/j.jmb.2006.09.008 http://dx.doi.org/10.1016/j.jmb.2006.09.008 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.1.174 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.174 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 2.1.1.174 http://enzyme.expasy.org/EC/2.1.1.174 EchoBASE EB2585 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2585 EcoGene EG12726 http://www.ecogene.org/geneInfo.php?eg_id=EG12726 EnsemblBacteria AAC76119 http://www.ensemblgenomes.org/id/AAC76119 EnsemblBacteria AAC76119 http://www.ensemblgenomes.org/id/AAC76119 EnsemblBacteria BAE77134 http://www.ensemblgenomes.org/id/BAE77134 EnsemblBacteria BAE77134 http://www.ensemblgenomes.org/id/BAE77134 EnsemblBacteria BAE77134 http://www.ensemblgenomes.org/id/BAE77134 EnsemblBacteria b3084 http://www.ensemblgenomes.org/id/b3084 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003676 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003676 GO_function GO:0052916 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052916 GO_process GO:0070475 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070475 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 GeneID 947589 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947589 HAMAP MF_01859 http://hamap.expasy.org/unirule/MF_01859 HOGENOM HOG000246323 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000246323&db=HOGENOM6 InParanoid P42596 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P42596 IntAct P42596 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P42596* IntEnz 2.1.1.174 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.174 InterPro IPR002052 http://www.ebi.ac.uk/interpro/entry/IPR002052 InterPro IPR007848 http://www.ebi.ac.uk/interpro/entry/IPR007848 InterPro IPR017237 http://www.ebi.ac.uk/interpro/entry/IPR017237 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW5513 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5513 KEGG_Gene eco:b3084 http://www.genome.jp/dbget-bin/www_bget?eco:b3084 KEGG_Orthology KO:K11391 http://www.genome.jp/dbget-bin/www_bget?KO:K11391 KEGG_Reaction rn:R07234 http://www.genome.jp/dbget-bin/www_bget?rn:R07234 OMA FHQQQVV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FHQQQVV PDB 4DCM http://www.ebi.ac.uk/pdbe-srv/view/entry/4DCM PDBsum 4DCM http://www.ebi.ac.uk/pdbsum/4DCM PSORT swissprot:RLMG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RLMG_ECOLI PSORT-B swissprot:RLMG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RLMG_ECOLI PSORT2 swissprot:RLMG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RLMG_ECOLI Pfam PF05175 http://pfam.xfam.org/family/PF05175 Phobius swissprot:RLMG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RLMG_ECOLI PhylomeDB P42596 http://phylomedb.org/?seqid=P42596 ProteinModelPortal P42596 http://www.proteinmodelportal.org/query/uniprot/P42596 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17010380 http://www.ncbi.nlm.nih.gov/pubmed/17010380 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417555 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417555 RefSeq WP_000018695 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000018695 SMR P42596 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P42596 STRING 511145.b3084 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3084&targetmode=cogs STRING COG2813 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2813&targetmode=cogs SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 UniProtKB RLMG_ECOLI http://www.uniprot.org/uniprot/RLMG_ECOLI UniProtKB-AC P42596 http://www.uniprot.org/uniprot/P42596 charge swissprot:RLMG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RLMG_ECOLI eggNOG COG2813 http://eggnogapi.embl.de/nog_data/html/tree/COG2813 eggNOG ENOG4105D8J http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D8J epestfind swissprot:RLMG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RLMG_ECOLI garnier swissprot:RLMG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RLMG_ECOLI helixturnhelix swissprot:RLMG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RLMG_ECOLI hmoment swissprot:RLMG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RLMG_ECOLI iep swissprot:RLMG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RLMG_ECOLI inforesidue swissprot:RLMG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RLMG_ECOLI octanol swissprot:RLMG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RLMG_ECOLI pepcoil swissprot:RLMG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RLMG_ECOLI pepdigest swissprot:RLMG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RLMG_ECOLI pepinfo swissprot:RLMG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RLMG_ECOLI pepnet swissprot:RLMG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RLMG_ECOLI pepstats swissprot:RLMG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RLMG_ECOLI pepwheel swissprot:RLMG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RLMG_ECOLI pepwindow swissprot:RLMG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RLMG_ECOLI sigcleave swissprot:RLMG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RLMG_ECOLI ## Database ID URL or Descriptions # BioGrid 4261142 6 # DISRUPTION PHENOTYPE Deletion of yhiD in addition to mgtA and corA leads to Mg(2+) auxotrophy. {ECO:0000269|PubMed 19798051}. # EcoGene EG11400 yhiD # FUNCTION YHID_ECOLI Could be involved in magnesium uptake. {ECO 0000269|PubMed 19798051}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006810 transport; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006810 transport # InterPro IPR003416 MgtC/SapB/SrpB/YhiD_fam # KEGG_Brite ko02000 Transporters # Organism YHID_ECOLI Escherichia coli (strain K12) # PATRIC 32122474 VBIEscCol129921_3615 # PIR S47728 S47728 # PRINTS PR01837 MGTCSAPBPROT # Pfam PF02308 MgtC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHID_ECOLI Putative magnesium transporter YhiD # RefSeq NP_417965 NC_000913.3 # RefSeq WP_001296814 NZ_LN832404.1 # SIMILARITY Belongs to the MgtC/SapB family. {ECO 0000305}. # SUBCELLULAR LOCATION YHID_ECOLI Cell inner membrane {ECO 0000305}; Multi- pass membrane protein {ECO 0000305}. # TCDB 9.B.20.1 the putative mg(2+) transporter-c (mgtc) family # eggNOG COG1285 LUCA # eggNOG ENOG4105KT7 Bacteria BLAST swissprot:YHID_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHID_ECOLI BioCyc ECOL316407:JW5670-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5670-MONOMER BioCyc EcoCyc:EG11400-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11400-MONOMER COG COG1285 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1285 DOI 10.1007/BF00282791 http://dx.doi.org/10.1007/BF00282791 DOI 10.1038/emboj.2009.288 http://dx.doi.org/10.1038/emboj.2009.288 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D11109 http://www.ebi.ac.uk/ena/data/view/D11109 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1372 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1372 EcoGene EG11400 http://www.ecogene.org/geneInfo.php?eg_id=EG11400 EnsemblBacteria AAC76533 http://www.ensemblgenomes.org/id/AAC76533 EnsemblBacteria AAC76533 http://www.ensemblgenomes.org/id/AAC76533 EnsemblBacteria BAE77786 http://www.ensemblgenomes.org/id/BAE77786 EnsemblBacteria BAE77786 http://www.ensemblgenomes.org/id/BAE77786 EnsemblBacteria BAE77786 http://www.ensemblgenomes.org/id/BAE77786 EnsemblBacteria b3508 http://www.ensemblgenomes.org/id/b3508 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948019 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948019 HOGENOM HOG000080250 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000080250&db=HOGENOM6 InParanoid P0AFV2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFV2 InterPro IPR003416 http://www.ebi.ac.uk/interpro/entry/IPR003416 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5670 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5670 KEGG_Gene eco:b3508 http://www.genome.jp/dbget-bin/www_bget?eco:b3508 KEGG_Orthology KO:K07507 http://www.genome.jp/dbget-bin/www_bget?KO:K07507 OMA NIHDINI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NIHDINI PRINTS PR01837 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01837 PSORT swissprot:YHID_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHID_ECOLI PSORT-B swissprot:YHID_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHID_ECOLI PSORT2 swissprot:YHID_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHID_ECOLI Pfam PF02308 http://pfam.xfam.org/family/PF02308 Phobius swissprot:YHID_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHID_ECOLI PhylomeDB P0AFV2 http://phylomedb.org/?seqid=P0AFV2 ProteinModelPortal P0AFV2 http://www.proteinmodelportal.org/query/uniprot/P0AFV2 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19798051 http://www.ncbi.nlm.nih.gov/pubmed/19798051 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 8455549 http://www.ncbi.nlm.nih.gov/pubmed/8455549 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417965 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417965 RefSeq WP_001296814 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001296814 STRING 511145.b3508 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3508&targetmode=cogs STRING COG1285 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1285&targetmode=cogs TCDB 9.B.20.1 http://www.tcdb.org/search/result.php?tc=9.B.20.1 UniProtKB YHID_ECOLI http://www.uniprot.org/uniprot/YHID_ECOLI UniProtKB-AC P0AFV2 http://www.uniprot.org/uniprot/P0AFV2 charge swissprot:YHID_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHID_ECOLI eggNOG COG1285 http://eggnogapi.embl.de/nog_data/html/tree/COG1285 eggNOG ENOG4105KT7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KT7 epestfind swissprot:YHID_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHID_ECOLI garnier swissprot:YHID_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHID_ECOLI helixturnhelix swissprot:YHID_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHID_ECOLI hmoment swissprot:YHID_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHID_ECOLI iep swissprot:YHID_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHID_ECOLI inforesidue swissprot:YHID_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHID_ECOLI octanol swissprot:YHID_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHID_ECOLI pepcoil swissprot:YHID_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHID_ECOLI pepdigest swissprot:YHID_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHID_ECOLI pepinfo swissprot:YHID_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHID_ECOLI pepnet swissprot:YHID_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHID_ECOLI pepstats swissprot:YHID_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHID_ECOLI pepwheel swissprot:YHID_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHID_ECOLI pepwindow swissprot:YHID_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHID_ECOLI sigcleave swissprot:YHID_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHID_ECOLI ## Database ID URL or Descriptions # BioGrid 4262680 9 # EcoGene EG11958 alsC # FUNCTION ALSC_ECOLI Part of the binding-protein-dependent transport system AlsBAC for D-allose; probably responsible for the translocation of the substrate across the membrane. {ECO 0000269|PubMed 9401019}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IBA:GO_Central. # GO_function GO:0015145 monosaccharide transmembrane transporter activity; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # InterPro IPR001851 ABC_transp_permease # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00217 D-Allose transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism ALSC_ECOLI Escherichia coli (strain K12) # PATRIC 32123727 VBIEscCol129921_4212 # PIR E65217 E65217 # Pfam PF02653 BPD_transp_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ALSC_ECOLI D-allose transport system permease protein AlsC # RefSeq NP_418510 NC_000913.3 # RefSeq WP_000507106 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION ALSC_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 3.A.1.2 the atp-binding cassette (abc) superfamily # eggNOG COG1172 LUCA # eggNOG ENOG4105CNN Bacteria BLAST swissprot:ALSC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ALSC_ECOLI BioCyc ECOL316407:JW4047-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4047-MONOMER BioCyc EcoCyc:YJCV-MONOMER http://biocyc.org/getid?id=EcoCyc:YJCV-MONOMER BioCyc MetaCyc:YJCV-MONOMER http://biocyc.org/getid?id=MetaCyc:YJCV-MONOMER COG COG1172 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1172 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB1901 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1901 EcoGene EG11958 http://www.ecogene.org/geneInfo.php?eg_id=EG11958 EnsemblBacteria AAC77047 http://www.ensemblgenomes.org/id/AAC77047 EnsemblBacteria AAC77047 http://www.ensemblgenomes.org/id/AAC77047 EnsemblBacteria BAE78089 http://www.ensemblgenomes.org/id/BAE78089 EnsemblBacteria BAE78089 http://www.ensemblgenomes.org/id/BAE78089 EnsemblBacteria BAE78089 http://www.ensemblgenomes.org/id/BAE78089 EnsemblBacteria b4086 http://www.ensemblgenomes.org/id/b4086 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015145 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GeneID 948594 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948594 HOGENOM HOG000212232 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000212232&db=HOGENOM6 InParanoid P32720 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32720 InterPro IPR001851 http://www.ebi.ac.uk/interpro/entry/IPR001851 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW4047 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4047 KEGG_Gene eco:b4086 http://www.genome.jp/dbget-bin/www_bget?eco:b4086 KEGG_Orthology KO:K10550 http://www.genome.jp/dbget-bin/www_bget?KO:K10550 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA IWIVFET http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IWIVFET PSORT swissprot:ALSC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ALSC_ECOLI PSORT-B swissprot:ALSC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ALSC_ECOLI PSORT2 swissprot:ALSC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ALSC_ECOLI Pfam PF02653 http://pfam.xfam.org/family/PF02653 Phobius swissprot:ALSC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ALSC_ECOLI PhylomeDB P32720 http://phylomedb.org/?seqid=P32720 ProteinModelPortal P32720 http://www.proteinmodelportal.org/query/uniprot/P32720 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9401019 http://www.ncbi.nlm.nih.gov/pubmed/9401019 RefSeq NP_418510 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418510 RefSeq WP_000507106 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000507106 SMR P32720 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32720 STRING 511145.b4086 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4086&targetmode=cogs STRING COG1172 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1172&targetmode=cogs TCDB 3.A.1.2 http://www.tcdb.org/search/result.php?tc=3.A.1.2 UniProtKB ALSC_ECOLI http://www.uniprot.org/uniprot/ALSC_ECOLI UniProtKB-AC P32720 http://www.uniprot.org/uniprot/P32720 charge swissprot:ALSC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ALSC_ECOLI eggNOG COG1172 http://eggnogapi.embl.de/nog_data/html/tree/COG1172 eggNOG ENOG4105CNN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CNN epestfind swissprot:ALSC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ALSC_ECOLI garnier swissprot:ALSC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ALSC_ECOLI helixturnhelix swissprot:ALSC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ALSC_ECOLI hmoment swissprot:ALSC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ALSC_ECOLI iep swissprot:ALSC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ALSC_ECOLI inforesidue swissprot:ALSC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ALSC_ECOLI octanol swissprot:ALSC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ALSC_ECOLI pepcoil swissprot:ALSC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ALSC_ECOLI pepdigest swissprot:ALSC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ALSC_ECOLI pepinfo swissprot:ALSC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ALSC_ECOLI pepnet swissprot:ALSC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ALSC_ECOLI pepstats swissprot:ALSC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ALSC_ECOLI pepwheel swissprot:ALSC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ALSC_ECOLI pepwindow swissprot:ALSC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ALSC_ECOLI sigcleave swissprot:ALSC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ALSC_ECOLI ## Database ID URL or Descriptions # EcoGene EG12263 bcsE # GO_function GO:0035438 cyclic-di-GMP binding; IDA:EcoCyc. # GOslim_function GO:0043167 ion binding # IntAct P37657 3 # InterPro IPR017745 Cellulose_biosynthesis_BcsE # MISCELLANEOUS BCSE_ECOLI Cellulose production is abolished in E.coli K12. # Organism BCSE_ECOLI Escherichia coli (strain K12) # PATRIC 32122538 VBIEscCol129921_3647 # PIR S47758 S47758 # Pfam PF10995 CBP_GIL # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BCSE_ECOLI Protein BcsE homolog # RefSeq NP_417993 NC_000913.3 # TIGRFAMs TIGR03369 cellulose_bcsE # eggNOG ENOG4105U74 Bacteria # eggNOG ENOG410ZIFY LUCA BLAST swissprot:BCSE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BCSE_ECOLI BioCyc ECOL316407:JW3504-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3504-MONOMER BioCyc EcoCyc:EG12263-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12263-MONOMER DIP DIP-12390N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12390N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2172 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2172 EcoGene EG12263 http://www.ecogene.org/geneInfo.php?eg_id=EG12263 EnsemblBacteria AAC76561 http://www.ensemblgenomes.org/id/AAC76561 EnsemblBacteria AAC76561 http://www.ensemblgenomes.org/id/AAC76561 EnsemblBacteria BAE77759 http://www.ensemblgenomes.org/id/BAE77759 EnsemblBacteria BAE77759 http://www.ensemblgenomes.org/id/BAE77759 EnsemblBacteria BAE77759 http://www.ensemblgenomes.org/id/BAE77759 EnsemblBacteria b3536 http://www.ensemblgenomes.org/id/b3536 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0035438 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035438 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GeneID 948050 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948050 HOGENOM HOG000125957 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125957&db=HOGENOM6 IntAct P37657 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37657* InterPro IPR017745 http://www.ebi.ac.uk/interpro/entry/IPR017745 KEGG_Gene ecj:JW3504 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3504 KEGG_Gene eco:b3536 http://www.genome.jp/dbget-bin/www_bget?eco:b3536 OMA GCGANMV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GCGANMV PSORT swissprot:BCSE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BCSE_ECOLI PSORT-B swissprot:BCSE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BCSE_ECOLI PSORT2 swissprot:BCSE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BCSE_ECOLI Pfam PF10995 http://pfam.xfam.org/family/PF10995 Phobius swissprot:BCSE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BCSE_ECOLI ProteinModelPortal P37657 http://www.proteinmodelportal.org/query/uniprot/P37657 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417993 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417993 STRING 511145.b3536 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3536&targetmode=cogs TIGRFAMs TIGR03369 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03369 UniProtKB BCSE_ECOLI http://www.uniprot.org/uniprot/BCSE_ECOLI UniProtKB-AC P37657 http://www.uniprot.org/uniprot/P37657 charge swissprot:BCSE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BCSE_ECOLI eggNOG ENOG4105U74 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105U74 eggNOG ENOG410ZIFY http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZIFY epestfind swissprot:BCSE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BCSE_ECOLI garnier swissprot:BCSE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BCSE_ECOLI helixturnhelix swissprot:BCSE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BCSE_ECOLI hmoment swissprot:BCSE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BCSE_ECOLI iep swissprot:BCSE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BCSE_ECOLI inforesidue swissprot:BCSE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BCSE_ECOLI octanol swissprot:BCSE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BCSE_ECOLI pepcoil swissprot:BCSE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BCSE_ECOLI pepdigest swissprot:BCSE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BCSE_ECOLI pepinfo swissprot:BCSE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BCSE_ECOLI pepnet swissprot:BCSE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BCSE_ECOLI pepstats swissprot:BCSE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BCSE_ECOLI pepwheel swissprot:BCSE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BCSE_ECOLI pepwindow swissprot:BCSE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BCSE_ECOLI sigcleave swissprot:BCSE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BCSE_ECOLI ## Database ID URL or Descriptions # BioGrid 4262754 253 # EcoGene EG10310 fimC # FUNCTION FIMC_ECOLI Required for the biogenesis of type 1 fimbriae. Binds and interact with FimH. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0044183 protein binding involved in protein folding; IDA:EcoCyc. # GO_process GO:0043711 pilus organization; IBA:GO_Central. # GO_process GO:0061077 chaperone-mediated protein folding; IDA:EcoCyc. # GO_process GO:0071555 cell wall organization; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006457 protein folding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 2.60.40.1070 -; 1. # Gene3D 2.60.40.360 -; 1. # INTERACTION FIMC_ECOLI Q83UM2 fimA (xeno); NbExp=2; IntAct=EBI-1028005, EBI-8548126; P08191 fimH; NbExp=6; IntAct=EBI-1028005, EBI-1028015; # IntAct P31697 8 # InterPro IPR001829 Pili_assmbl_chaperone_bac # InterPro IPR008962 PapD-like # InterPro IPR016147 Pili_assmbl_chaperone_N # InterPro IPR016148 Pili_assmbl_chaperone_C # InterPro IPR018046 Pili_assmbl_chaperone_CS # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Brite ko02044 Secretion system # KEGG_Brite ko03110 Chaperones and folding catalysts # Organism FIMC_ECOLI Escherichia coli (strain K12) # PATRIC 32124228 VBIEscCol129921_4457 # PDB 1BF8 NMR; -; A=37-241 # PDB 1KIU X-ray; 3.00 A; A/C/E/G/I/K/M/O=37-241 # PDB 1KLF X-ray; 2.79 A; A/C/E/G/I/K/M/O=37-241 # PDB 1QUN X-ray; 2.80 A; A/C/E/G/I/K/M/O=37-241 # PDB 1ZE3 X-ray; 1.84 A; C=37-241 # PDB 3BWU X-ray; 1.76 A; C=37-241 # PDB 3JWN X-ray; 2.69 A; C/I=37-241 # PDB 3RFZ X-ray; 2.80 A; C/F=37-241 # PDB 3SQB X-ray; 3.20 A; A/C/E/G=37-241 # PDB 4DWH X-ray; 2.50 A; A/C=37-241 # PDB 4J3O X-ray; 3.80 A; C=37-241 # PIR S56541 S56541 # PRINTS PR00969 CHAPERONPILI # PROSITE PS00635 PILI_CHAPERONE # Pfam PF00345 PapD_N # Pfam PF02753 PapD_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FIMC_ECOLI Chaperone protein FimC # RefSeq NP_418736 NC_000913.3 # RefSeq WP_000066547 NZ_LN832404.1 # SIMILARITY Belongs to the periplasmic pilus chaperone family. {ECO 0000305}. # SIMILARITY Contains 1 Ig-like (immunoglobulin-like) domain. {ECO 0000305}. # SUBCELLULAR LOCATION FIMC_ECOLI Periplasm. # SUPFAM SSF49354 SSF49354 # SUPFAM SSF49584 SSF49584 # eggNOG ENOG4108NAE Bacteria # eggNOG ENOG410ZYUF LUCA BLAST swissprot:FIMC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FIMC_ECOLI BioCyc ECOL316407:JW4279-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4279-MONOMER BioCyc EcoCyc:EG10310-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10310-MONOMER COG COG3121 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3121 DIP DIP-9611N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9611N DOI 10.1016/0923-2508(92)90070-5 http://dx.doi.org/10.1016/0923-2508(92)90070-5 DOI 10.1038/2325 http://dx.doi.org/10.1038/2325 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.90.18.8397 http://dx.doi.org/10.1073/pnas.90.18.8397 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1099/00222615-44-6-444 http://dx.doi.org/10.1099/00222615-44-6-444 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L14598 http://www.ebi.ac.uk/ena/data/view/L14598 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X51655 http://www.ebi.ac.uk/ena/data/view/X51655 EMBL Z37500 http://www.ebi.ac.uk/ena/data/view/Z37500 EchoBASE EB0306 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0306 EcoGene EG10310 http://www.ecogene.org/geneInfo.php?eg_id=EG10310 EnsemblBacteria AAC77272 http://www.ensemblgenomes.org/id/AAC77272 EnsemblBacteria AAC77272 http://www.ensemblgenomes.org/id/AAC77272 EnsemblBacteria BAE78309 http://www.ensemblgenomes.org/id/BAE78309 EnsemblBacteria BAE78309 http://www.ensemblgenomes.org/id/BAE78309 EnsemblBacteria BAE78309 http://www.ensemblgenomes.org/id/BAE78309 EnsemblBacteria b4316 http://www.ensemblgenomes.org/id/b4316 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0044183 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044183 GO_process GO:0043711 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043711 GO_process GO:0061077 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061077 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 2.60.40.1070 http://www.cathdb.info/version/latest/superfamily/2.60.40.1070 Gene3D 2.60.40.360 http://www.cathdb.info/version/latest/superfamily/2.60.40.360 GeneID 948843 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948843 HOGENOM HOG000260152 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260152&db=HOGENOM6 InParanoid P31697 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31697 IntAct P31697 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31697* InterPro IPR001829 http://www.ebi.ac.uk/interpro/entry/IPR001829 InterPro IPR008962 http://www.ebi.ac.uk/interpro/entry/IPR008962 InterPro IPR016147 http://www.ebi.ac.uk/interpro/entry/IPR016147 InterPro IPR016148 http://www.ebi.ac.uk/interpro/entry/IPR016148 InterPro IPR018046 http://www.ebi.ac.uk/interpro/entry/IPR018046 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW4279 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4279 KEGG_Gene eco:b4316 http://www.genome.jp/dbget-bin/www_bget?eco:b4316 KEGG_Orthology KO:K07346 http://www.genome.jp/dbget-bin/www_bget?KO:K07346 MINT MINT-2831193 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-2831193 OMA PPLFAMQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PPLFAMQ PDB 1BF8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1BF8 PDB 1KIU http://www.ebi.ac.uk/pdbe-srv/view/entry/1KIU PDB 1KLF http://www.ebi.ac.uk/pdbe-srv/view/entry/1KLF PDB 1QUN http://www.ebi.ac.uk/pdbe-srv/view/entry/1QUN PDB 1ZE3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZE3 PDB 3BWU http://www.ebi.ac.uk/pdbe-srv/view/entry/3BWU PDB 3JWN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JWN PDB 3RFZ http://www.ebi.ac.uk/pdbe-srv/view/entry/3RFZ PDB 3SQB http://www.ebi.ac.uk/pdbe-srv/view/entry/3SQB PDB 4DWH http://www.ebi.ac.uk/pdbe-srv/view/entry/4DWH PDB 4J3O http://www.ebi.ac.uk/pdbe-srv/view/entry/4J3O PDBsum 1BF8 http://www.ebi.ac.uk/pdbsum/1BF8 PDBsum 1KIU http://www.ebi.ac.uk/pdbsum/1KIU PDBsum 1KLF http://www.ebi.ac.uk/pdbsum/1KLF PDBsum 1QUN http://www.ebi.ac.uk/pdbsum/1QUN PDBsum 1ZE3 http://www.ebi.ac.uk/pdbsum/1ZE3 PDBsum 3BWU http://www.ebi.ac.uk/pdbsum/3BWU PDBsum 3JWN http://www.ebi.ac.uk/pdbsum/3JWN PDBsum 3RFZ http://www.ebi.ac.uk/pdbsum/3RFZ PDBsum 3SQB http://www.ebi.ac.uk/pdbsum/3SQB PDBsum 4DWH http://www.ebi.ac.uk/pdbsum/4DWH PDBsum 4J3O http://www.ebi.ac.uk/pdbsum/4J3O PRINTS PR00969 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00969 PROSITE PS00635 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00635 PSORT swissprot:FIMC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FIMC_ECOLI PSORT-B swissprot:FIMC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FIMC_ECOLI PSORT2 swissprot:FIMC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FIMC_ECOLI Pfam PF00345 http://pfam.xfam.org/family/PF00345 Pfam PF02753 http://pfam.xfam.org/family/PF02753 Phobius swissprot:FIMC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FIMC_ECOLI PhylomeDB P31697 http://phylomedb.org/?seqid=P31697 ProteinModelPortal P31697 http://www.proteinmodelportal.org/query/uniprot/P31697 PubMed 1363735 http://www.ncbi.nlm.nih.gov/pubmed/1363735 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8104335 http://www.ncbi.nlm.nih.gov/pubmed/8104335 PubMed 8636962 http://www.ncbi.nlm.nih.gov/pubmed/8636962 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9783748 http://www.ncbi.nlm.nih.gov/pubmed/9783748 RefSeq NP_418736 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418736 RefSeq WP_000066547 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000066547 SMR P31697 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31697 STRING 511145.b4316 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4316&targetmode=cogs STRING COG3121 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3121&targetmode=cogs SUPFAM SSF49354 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49354 SUPFAM SSF49584 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49584 UniProtKB FIMC_ECOLI http://www.uniprot.org/uniprot/FIMC_ECOLI UniProtKB-AC P31697 http://www.uniprot.org/uniprot/P31697 charge swissprot:FIMC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FIMC_ECOLI eggNOG ENOG4108NAE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108NAE eggNOG ENOG410ZYUF http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZYUF epestfind swissprot:FIMC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FIMC_ECOLI garnier swissprot:FIMC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FIMC_ECOLI helixturnhelix swissprot:FIMC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FIMC_ECOLI hmoment swissprot:FIMC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FIMC_ECOLI iep swissprot:FIMC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FIMC_ECOLI inforesidue swissprot:FIMC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FIMC_ECOLI octanol swissprot:FIMC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FIMC_ECOLI pepcoil swissprot:FIMC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FIMC_ECOLI pepdigest swissprot:FIMC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FIMC_ECOLI pepinfo swissprot:FIMC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FIMC_ECOLI pepnet swissprot:FIMC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FIMC_ECOLI pepstats swissprot:FIMC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FIMC_ECOLI pepwheel swissprot:FIMC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FIMC_ECOLI pepwindow swissprot:FIMC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FIMC_ECOLI sigcleave swissprot:FIMC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FIMC_ECOLI ## Database ID URL or Descriptions # BRENDA 5.3.3.18 2026 # BioGrid 4260969 375 # CATALYTIC ACTIVITY PAAG_ECOLI 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA = 2- oxepin-2(3H)-ylideneacetyl-CoA. # DISRUPTION PHENOTYPE Mutants accumulate ring-1,2-dihydroxy-1,2- dihydrophenylacetyl lactone and are unable to use phenylacetate as a carbon source. {ECO:0000269|PubMed 12846838}. # EcoGene EG13741 paaG # FUNCTION PAAG_ECOLI Catalyzes the reversible conversion of the epoxide to 2- oxepin-2(3H)-ylideneacetyl-CoA (oxepin-CoA). {ECO 0000269|PubMed 12846838, ECO 0000269|PubMed 20660314, ECO 0000269|PubMed 9748275}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0016829 lyase activity; IEA:UniProtKB-KW. # GO_function GO:0016853 isomerase activity; IDA:UniProtKB. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0010124 phenylacetate catabolic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.12.10 -; 1. # Gene3D 3.90.226.10 -; 1. # INDUCTION PAAG_ECOLI Activated by cAMP receptor protein (CRP), integration host factor (IHF) and by phenylacetyl-coenzyme A (PA-CoA) that prevents PaaX from binding its target sequences. Inhibited by PaaX. {ECO 0000269|PubMed 10766858, ECO 0000269|PubMed 9748275}. # IntAct P77467 9 # InterPro IPR001753 Crotonase_core_superfam # InterPro IPR011968 PaaB1 # InterPro IPR014748 Crontonase_C # InterPro IPR029045 ClpP/crotonase-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00360 Phenylalanine metabolism # Organism PAAG_ECOLI Escherichia coli (strain K12) # PATHWAY PAAG_ECOLI Aromatic compound metabolism; phenylacetate degradation. # PATRIC 32118074 VBIEscCol129921_1457 # PDB 4FZW X-ray; 2.55 A; C/D=1-262 # PIR E64890 E64890 # Pfam PF00378 ECH_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PAAG_ECOLI 1,2-epoxyphenylacetyl-CoA isomerase # RefSeq NP_415912 NC_000913.3 # RefSeq WP_000969784 NZ_LN832404.1 # SIMILARITY Belongs to the enoyl-CoA hydratase/isomerase family. {ECO 0000305}. # SUPFAM SSF52096 SSF52096 # TIGRFAMs TIGR02280 PaaB1 # eggNOG COG1024 LUCA # eggNOG ENOG4108UKI Bacteria BLAST swissprot:PAAG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PAAG_ECOLI BioCyc ECOL316407:JW1389-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1389-MONOMER BioCyc EcoCyc:G6715-MONOMER http://biocyc.org/getid?id=EcoCyc:G6715-MONOMER COG COG1024 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1432-1033.2003.03683.x http://dx.doi.org/10.1046/j.1432-1033.2003.03683.x DOI 10.1073/pnas.1005399107 http://dx.doi.org/10.1073/pnas.1005399107 DOI 10.1074/jbc.273.40.25974 http://dx.doi.org/10.1074/jbc.273.40.25974 DOI 10.1074/jbc.275.16.12214 http://dx.doi.org/10.1074/jbc.275.16.12214 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.3.3.18 http://www.genome.jp/dbget-bin/www_bget?EC:5.3.3.18 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X97452 http://www.ebi.ac.uk/ena/data/view/X97452 ENZYME 5.3.3.18 http://enzyme.expasy.org/EC/5.3.3.18 EchoBASE EB3504 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3504 EcoGene EG13741 http://www.ecogene.org/geneInfo.php?eg_id=EG13741 EnsemblBacteria AAC74476 http://www.ensemblgenomes.org/id/AAC74476 EnsemblBacteria AAC74476 http://www.ensemblgenomes.org/id/AAC74476 EnsemblBacteria BAA15000 http://www.ensemblgenomes.org/id/BAA15000 EnsemblBacteria BAA15000 http://www.ensemblgenomes.org/id/BAA15000 EnsemblBacteria BAA15000 http://www.ensemblgenomes.org/id/BAA15000 EnsemblBacteria b1394 http://www.ensemblgenomes.org/id/b1394 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GO_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0010124 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010124 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.12.10 http://www.cathdb.info/version/latest/superfamily/1.10.12.10 Gene3D 3.90.226.10 http://www.cathdb.info/version/latest/superfamily/3.90.226.10 GeneID 946263 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946263 HOGENOM HOG000027949 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000027949&db=HOGENOM6 InParanoid P77467 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77467 IntAct P77467 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77467* IntEnz 5.3.3.18 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.3.3.18 InterPro IPR001753 http://www.ebi.ac.uk/interpro/entry/IPR001753 InterPro IPR011968 http://www.ebi.ac.uk/interpro/entry/IPR011968 InterPro IPR014748 http://www.ebi.ac.uk/interpro/entry/IPR014748 InterPro IPR029045 http://www.ebi.ac.uk/interpro/entry/IPR029045 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1389 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1389 KEGG_Gene eco:b1394 http://www.genome.jp/dbget-bin/www_bget?eco:b1394 KEGG_Orthology KO:K15866 http://www.genome.jp/dbget-bin/www_bget?KO:K15866 KEGG_Pathway ko00360 http://www.genome.jp/kegg-bin/show_pathway?ko00360 KEGG_Reaction rn:R09837 http://www.genome.jp/dbget-bin/www_bget?rn:R09837 KEGG_Reaction rn:R09839 http://www.genome.jp/dbget-bin/www_bget?rn:R09839 OMA NTAMHLE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NTAMHLE PDB 4FZW http://www.ebi.ac.uk/pdbe-srv/view/entry/4FZW PDBsum 4FZW http://www.ebi.ac.uk/pdbsum/4FZW PSORT swissprot:PAAG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PAAG_ECOLI PSORT-B swissprot:PAAG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PAAG_ECOLI PSORT2 swissprot:PAAG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PAAG_ECOLI Pfam PF00378 http://pfam.xfam.org/family/PF00378 Phobius swissprot:PAAG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PAAG_ECOLI PhylomeDB P77467 http://phylomedb.org/?seqid=P77467 ProteinModelPortal P77467 http://www.proteinmodelportal.org/query/uniprot/P77467 PubMed 10766858 http://www.ncbi.nlm.nih.gov/pubmed/10766858 PubMed 12846838 http://www.ncbi.nlm.nih.gov/pubmed/12846838 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20660314 http://www.ncbi.nlm.nih.gov/pubmed/20660314 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9748275 http://www.ncbi.nlm.nih.gov/pubmed/9748275 RefSeq NP_415912 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415912 RefSeq WP_000969784 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000969784 SMR P77467 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77467 STRING 511145.b1394 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1394&targetmode=cogs STRING COG1024 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1024&targetmode=cogs SUPFAM SSF52096 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52096 TIGRFAMs TIGR02280 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02280 UniProtKB PAAG_ECOLI http://www.uniprot.org/uniprot/PAAG_ECOLI UniProtKB-AC P77467 http://www.uniprot.org/uniprot/P77467 charge swissprot:PAAG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PAAG_ECOLI eggNOG COG1024 http://eggnogapi.embl.de/nog_data/html/tree/COG1024 eggNOG ENOG4108UKI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UKI epestfind swissprot:PAAG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PAAG_ECOLI garnier swissprot:PAAG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PAAG_ECOLI helixturnhelix swissprot:PAAG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PAAG_ECOLI hmoment swissprot:PAAG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PAAG_ECOLI iep swissprot:PAAG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PAAG_ECOLI inforesidue swissprot:PAAG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PAAG_ECOLI octanol swissprot:PAAG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PAAG_ECOLI pepcoil swissprot:PAAG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PAAG_ECOLI pepdigest swissprot:PAAG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PAAG_ECOLI pepinfo swissprot:PAAG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PAAG_ECOLI pepnet swissprot:PAAG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PAAG_ECOLI pepstats swissprot:PAAG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PAAG_ECOLI pepwheel swissprot:PAAG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PAAG_ECOLI pepwindow swissprot:PAAG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PAAG_ECOLI sigcleave swissprot:PAAG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PAAG_ECOLI ## Database ID URL or Descriptions # AltName RIR3_ECOLI R1E protein # AltName RIR3_ECOLI Ribonucleotide reductase 2 # BRENDA 1.17.4 2026 # BioGrid 4259221 220 # CATALYTIC ACTIVITY RIR3_ECOLI 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H(2)O = ribonucleoside diphosphate + thioredoxin. # ENZYME REGULATION Under complex allosteric control mediated by deoxynucleoside triphosphates and ATP binding. The type of nucleotide bound at the specificity site determines substrate preference. It seems probable that ATP makes the enzyme reduce CDP and UDP, dGTP favors ADP reduction and dTTP favors GDP reduction (By similarity). {ECO 0000250}. # EcoGene EG20257 nrdE # FUNCTION RIR3_ECOLI Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1E contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide. # GO_component GO:0005737 cytoplasm; ISA:EcoliWiki. # GO_component GO:0005971 ribonucleoside-diphosphate reductase complex; IGI:EcoliWiki. # GO_function GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IEA:UniProtKB-EC. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0006260 DNA replication; IEA:UniProtKB-UniPathway. # GO_process GO:0009263 deoxyribonucleotide biosynthetic process; IGI:EcoliWiki. # GO_process GO:0015949 nucleobase-containing small molecule interconversion; IGI:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # INDUCTION Induced 2-fold by hydroxyurea. {ECO:0000269|PubMed 20005847}. # IntAct P39452 9 # InterPro IPR000788 RNR_lg_C # InterPro IPR008926 RNR_R1-su_N # InterPro IPR013346 NrdE_NrdA # InterPro IPR013509 RNR_lsu_N # InterPro IPR013554 RNR_N # InterPro IPR026459 RNR_1b_NrdE # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00240 Pyrimidine metabolism # Organism RIR3_ECOLI Escherichia coli (strain K12) # PATHWAY RIR3_ECOLI Genetic information processing; DNA replication. # PATRIC 32120740 VBIEscCol129921_2767 # PIR D65047 D65047 # PRINTS PR01183 RIBORDTASEM1 # PROSITE PS00089 RIBORED_LARGE # Pfam PF00317 Ribonuc_red_lgN # Pfam PF02867 Ribonuc_red_lgC # Pfam PF08343 RNR_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RIR3_ECOLI Ribonucleoside-diphosphate reductase 2 subunit alpha # RefSeq NP_417161 NC_000913.3 # RefSeq WP_000246534 NZ_LN832404.1 # SIMILARITY Belongs to the ribonucleoside diphosphate reductase large chain family. {ECO 0000305}. # SUBUNIT Tetramer of two alpha and two beta subunits. {ECO 0000250}. # SUPFAM SSF48168 SSF48168 # TIGRFAMs TIGR02506 NrdE_NrdA # TIGRFAMs TIGR04170 RNR_1b_NrdE # eggNOG COG0209 LUCA # eggNOG ENOG4105BZH Bacteria BLAST swissprot:RIR3_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RIR3_ECOLI BioCyc ECOL316407:JW2650-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2650-MONOMER BioCyc EcoCyc:NRDE-MONOMER http://biocyc.org/getid?id=EcoCyc:NRDE-MONOMER BioCyc MetaCyc:NRDE-MONOMER http://biocyc.org/getid?id=MetaCyc:NRDE-MONOMER COG COG0209 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0209 DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1996.424950.x http://dx.doi.org/10.1046/j.1365-2958.1996.424950.x DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.17.4.1 http://www.genome.jp/dbget-bin/www_bget?EC:1.17.4.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M31530 http://www.ebi.ac.uk/ena/data/view/M31530 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X79787 http://www.ebi.ac.uk/ena/data/view/X79787 ENZYME 1.17.4.1 http://enzyme.expasy.org/EC/1.17.4.1 EchoBASE EB4158 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4158 EcoGene EG20257 http://www.ecogene.org/geneInfo.php?eg_id=EG20257 EnsemblBacteria AAC75722 http://www.ensemblgenomes.org/id/AAC75722 EnsemblBacteria AAC75722 http://www.ensemblgenomes.org/id/AAC75722 EnsemblBacteria BAA16539 http://www.ensemblgenomes.org/id/BAA16539 EnsemblBacteria BAA16539 http://www.ensemblgenomes.org/id/BAA16539 EnsemblBacteria BAA16539 http://www.ensemblgenomes.org/id/BAA16539 EnsemblBacteria b2675 http://www.ensemblgenomes.org/id/b2675 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005971 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005971 GO_function GO:0004748 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004748 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260 GO_process GO:0009263 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009263 GO_process GO:0015949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015949 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 947155 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947155 HOGENOM HOG000246165 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000246165&db=HOGENOM6 InParanoid P39452 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39452 IntAct P39452 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39452* IntEnz 1.17.4.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.17.4.1 InterPro IPR000788 http://www.ebi.ac.uk/interpro/entry/IPR000788 InterPro IPR008926 http://www.ebi.ac.uk/interpro/entry/IPR008926 InterPro IPR013346 http://www.ebi.ac.uk/interpro/entry/IPR013346 InterPro IPR013509 http://www.ebi.ac.uk/interpro/entry/IPR013509 InterPro IPR013554 http://www.ebi.ac.uk/interpro/entry/IPR013554 InterPro IPR026459 http://www.ebi.ac.uk/interpro/entry/IPR026459 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW2650 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2650 KEGG_Gene eco:b2675 http://www.genome.jp/dbget-bin/www_bget?eco:b2675 KEGG_Orthology KO:K00525 http://www.genome.jp/dbget-bin/www_bget?KO:K00525 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Reaction rn:R02017 http://www.genome.jp/dbget-bin/www_bget?rn:R02017 KEGG_Reaction rn:R02018 http://www.genome.jp/dbget-bin/www_bget?rn:R02018 KEGG_Reaction rn:R02019 http://www.genome.jp/dbget-bin/www_bget?rn:R02019 KEGG_Reaction rn:R02024 http://www.genome.jp/dbget-bin/www_bget?rn:R02024 OMA TLFMTDK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TLFMTDK PRINTS PR01183 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01183 PROSITE PS00089 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00089 PSORT swissprot:RIR3_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RIR3_ECOLI PSORT-B swissprot:RIR3_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RIR3_ECOLI PSORT2 swissprot:RIR3_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RIR3_ECOLI Pfam PF00317 http://pfam.xfam.org/family/PF00317 Pfam PF02867 http://pfam.xfam.org/family/PF02867 Pfam PF08343 http://pfam.xfam.org/family/PF08343 Phobius swissprot:RIR3_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RIR3_ECOLI PhylomeDB P39452 http://phylomedb.org/?seqid=P39452 ProteinModelPortal P39452 http://www.proteinmodelportal.org/query/uniprot/P39452 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 2158980 http://www.ncbi.nlm.nih.gov/pubmed/2158980 PubMed 8820648 http://www.ncbi.nlm.nih.gov/pubmed/8820648 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417161 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417161 RefSeq WP_000246534 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000246534 SMR P39452 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39452 STRING 511145.b2675 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2675&targetmode=cogs STRING COG0209 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0209&targetmode=cogs SUPFAM SSF48168 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48168 TIGRFAMs TIGR02506 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02506 TIGRFAMs TIGR04170 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR04170 UniProtKB RIR3_ECOLI http://www.uniprot.org/uniprot/RIR3_ECOLI UniProtKB-AC P39452 http://www.uniprot.org/uniprot/P39452 charge swissprot:RIR3_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RIR3_ECOLI eggNOG COG0209 http://eggnogapi.embl.de/nog_data/html/tree/COG0209 eggNOG ENOG4105BZH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZH epestfind swissprot:RIR3_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RIR3_ECOLI garnier swissprot:RIR3_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RIR3_ECOLI helixturnhelix swissprot:RIR3_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RIR3_ECOLI hmoment swissprot:RIR3_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RIR3_ECOLI iep swissprot:RIR3_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RIR3_ECOLI inforesidue swissprot:RIR3_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RIR3_ECOLI octanol swissprot:RIR3_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RIR3_ECOLI pepcoil swissprot:RIR3_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RIR3_ECOLI pepdigest swissprot:RIR3_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RIR3_ECOLI pepinfo swissprot:RIR3_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RIR3_ECOLI pepnet swissprot:RIR3_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RIR3_ECOLI pepstats swissprot:RIR3_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RIR3_ECOLI pepwheel swissprot:RIR3_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RIR3_ECOLI pepwindow swissprot:RIR3_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RIR3_ECOLI sigcleave swissprot:RIR3_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RIR3_ECOLI ## Database ID URL or Descriptions # BioGrid 4260916 6 # EcoGene EG13834 ydfV # Organism YDFV_ECOLI Escherichia coli (strain K12) # PIR H64911 H64911 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDFV_ECOLI Uncharacterized protein YdfV # RefSeq NP_416083 NC_000913.3 BLAST swissprot:YDFV_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDFV_ECOLI BioCyc ECOL316407:JW1557-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1557-MONOMER BioCyc EcoCyc:G6832-MONOMER http://biocyc.org/getid?id=EcoCyc:G6832-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3595 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3595 EcoGene EG13834 http://www.ecogene.org/geneInfo.php?eg_id=EG13834 EnsemblBacteria AAC74638 http://www.ensemblgenomes.org/id/AAC74638 EnsemblBacteria AAC74638 http://www.ensemblgenomes.org/id/AAC74638 EnsemblBacteria BAE76471 http://www.ensemblgenomes.org/id/BAE76471 EnsemblBacteria BAE76471 http://www.ensemblgenomes.org/id/BAE76471 EnsemblBacteria BAE76471 http://www.ensemblgenomes.org/id/BAE76471 EnsemblBacteria b1565 http://www.ensemblgenomes.org/id/b1565 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 948801 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948801 HOGENOM HOG000054891 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000054891&db=HOGENOM6 IntAct P76163 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76163* KEGG_Gene ecj:JW1557 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1557 KEGG_Gene eco:b1565 http://www.genome.jp/dbget-bin/www_bget?eco:b1565 OMA CAGQLFF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CAGQLFF PSORT swissprot:YDFV_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDFV_ECOLI PSORT-B swissprot:YDFV_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDFV_ECOLI PSORT2 swissprot:YDFV_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDFV_ECOLI Phobius swissprot:YDFV_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDFV_ECOLI ProteinModelPortal P76163 http://www.proteinmodelportal.org/query/uniprot/P76163 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416083 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416083 SMR P76163 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76163 STRING 511145.b1565 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1565&targetmode=cogs UniProtKB YDFV_ECOLI http://www.uniprot.org/uniprot/YDFV_ECOLI UniProtKB-AC P76163 http://www.uniprot.org/uniprot/P76163 charge swissprot:YDFV_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDFV_ECOLI epestfind swissprot:YDFV_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDFV_ECOLI garnier swissprot:YDFV_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDFV_ECOLI helixturnhelix swissprot:YDFV_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDFV_ECOLI hmoment swissprot:YDFV_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDFV_ECOLI iep swissprot:YDFV_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDFV_ECOLI inforesidue swissprot:YDFV_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDFV_ECOLI octanol swissprot:YDFV_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDFV_ECOLI pepcoil swissprot:YDFV_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDFV_ECOLI pepdigest swissprot:YDFV_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDFV_ECOLI pepinfo swissprot:YDFV_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDFV_ECOLI pepnet swissprot:YDFV_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDFV_ECOLI pepstats swissprot:YDFV_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDFV_ECOLI pepwheel swissprot:YDFV_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDFV_ECOLI pepwindow swissprot:YDFV_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDFV_ECOLI sigcleave swissprot:YDFV_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDFV_ECOLI ## Database ID URL or Descriptions # BioGrid 4260886 3 # EcoGene EG14100 yfbP # Gene3D 1.25.40.10 -; 1. # InterPro IPR011990 TPR-like_helical_dom # Organism YFBP_ECOLI Escherichia coli (strain K12) # PATRIC 32119917 VBIEscCol129921_2368 # PIR A64999 A64999 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFBP_ECOLI Uncharacterized protein YfbP # RefSeq NP_416778 NC_000913.3 # RefSeq WP_000767280 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAE76683.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SUPFAM SSF48452 SSF48452 # eggNOG ENOG4106HDC Bacteria # eggNOG ENOG410Y787 LUCA BLAST swissprot:YFBP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFBP_ECOLI BioCyc ECOL316407:JW2270-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2270-MONOMER BioCyc EcoCyc:G7182-MONOMER http://biocyc.org/getid?id=EcoCyc:G7182-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3853 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3853 EcoGene EG14100 http://www.ecogene.org/geneInfo.php?eg_id=EG14100 EnsemblBacteria AAC75335 http://www.ensemblgenomes.org/id/AAC75335 EnsemblBacteria AAC75335 http://www.ensemblgenomes.org/id/AAC75335 EnsemblBacteria BAE76683 http://www.ensemblgenomes.org/id/BAE76683 EnsemblBacteria BAE76683 http://www.ensemblgenomes.org/id/BAE76683 EnsemblBacteria BAE76683 http://www.ensemblgenomes.org/id/BAE76683 EnsemblBacteria b2275 http://www.ensemblgenomes.org/id/b2275 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 1.25.40.10 http://www.cathdb.info/version/latest/superfamily/1.25.40.10 GeneID 946754 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946754 HOGENOM HOG000009756 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009756&db=HOGENOM6 IntAct P76486 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76486* InterPro IPR011990 http://www.ebi.ac.uk/interpro/entry/IPR011990 KEGG_Gene ecj:JW2270 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2270 KEGG_Gene eco:b2275 http://www.genome.jp/dbget-bin/www_bget?eco:b2275 OMA YANAGEY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YANAGEY PSORT swissprot:YFBP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFBP_ECOLI PSORT-B swissprot:YFBP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFBP_ECOLI PSORT2 swissprot:YFBP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFBP_ECOLI Phobius swissprot:YFBP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFBP_ECOLI ProteinModelPortal P76486 http://www.proteinmodelportal.org/query/uniprot/P76486 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416778 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416778 RefSeq WP_000767280 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000767280 SMR P76486 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76486 STRING 511145.b2275 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2275&targetmode=cogs SUPFAM SSF48452 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48452 UniProtKB YFBP_ECOLI http://www.uniprot.org/uniprot/YFBP_ECOLI UniProtKB-AC P76486 http://www.uniprot.org/uniprot/P76486 charge swissprot:YFBP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFBP_ECOLI eggNOG ENOG4106HDC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106HDC eggNOG ENOG410Y787 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y787 epestfind swissprot:YFBP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFBP_ECOLI garnier swissprot:YFBP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFBP_ECOLI helixturnhelix swissprot:YFBP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFBP_ECOLI hmoment swissprot:YFBP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFBP_ECOLI iep swissprot:YFBP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFBP_ECOLI inforesidue swissprot:YFBP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFBP_ECOLI octanol swissprot:YFBP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFBP_ECOLI pepcoil swissprot:YFBP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFBP_ECOLI pepdigest swissprot:YFBP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFBP_ECOLI pepinfo swissprot:YFBP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFBP_ECOLI pepnet swissprot:YFBP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFBP_ECOLI pepstats swissprot:YFBP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFBP_ECOLI pepwheel swissprot:YFBP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFBP_ECOLI pepwindow swissprot:YFBP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFBP_ECOLI sigcleave swissprot:YFBP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFBP_ECOLI ## Database ID URL or Descriptions # BioGrid 4260535 19 # EcoGene EG14129 yfcZ # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # IntAct P0AD33 7 # InterPro IPR005272 CHP00743 # Organism YFCZ_ECOLI Escherichia coli (strain K12) # PATRIC 32120059 VBIEscCol129921_2439 # PIR E65007 E65007 # Pfam PF04175 DUF406 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFCZ_ECOLI UPF0381 protein YfcZ # RefSeq NP_416845 NC_000913.3 # RefSeq WP_001296261 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0381 family. {ECO 0000305}. # TIGRFAMs TIGR00743 TIGR00743 # eggNOG COG3691 LUCA # eggNOG ENOG4105KZW Bacteria BLAST swissprot:YFCZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFCZ_ECOLI BioCyc ECOL316407:JW2340-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2340-MONOMER BioCyc EcoCyc:G7214-MONOMER http://biocyc.org/getid?id=EcoCyc:G7214-MONOMER DIP DIP-47925N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47925N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3881 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3881 EcoGene EG14129 http://www.ecogene.org/geneInfo.php?eg_id=EG14129 EnsemblBacteria AAC75403 http://www.ensemblgenomes.org/id/AAC75403 EnsemblBacteria AAC75403 http://www.ensemblgenomes.org/id/AAC75403 EnsemblBacteria BAA16198 http://www.ensemblgenomes.org/id/BAA16198 EnsemblBacteria BAA16198 http://www.ensemblgenomes.org/id/BAA16198 EnsemblBacteria BAA16198 http://www.ensemblgenomes.org/id/BAA16198 EnsemblBacteria b2343 http://www.ensemblgenomes.org/id/b2343 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GeneID 948817 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948817 HOGENOM HOG000270330 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000270330&db=HOGENOM6 IntAct P0AD33 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AD33* InterPro IPR005272 http://www.ebi.ac.uk/interpro/entry/IPR005272 KEGG_Gene ecj:JW2340 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2340 KEGG_Gene eco:b2343 http://www.genome.jp/dbget-bin/www_bget?eco:b2343 OMA DPCEIKS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DPCEIKS PSORT swissprot:YFCZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFCZ_ECOLI PSORT-B swissprot:YFCZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFCZ_ECOLI PSORT2 swissprot:YFCZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFCZ_ECOLI Pfam PF04175 http://pfam.xfam.org/family/PF04175 Phobius swissprot:YFCZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFCZ_ECOLI ProteinModelPortal P0AD33 http://www.proteinmodelportal.org/query/uniprot/P0AD33 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416845 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416845 RefSeq WP_001296261 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001296261 SMR P0AD33 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AD33 STRING 511145.b2343 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2343&targetmode=cogs TIGRFAMs TIGR00743 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00743 UniProtKB YFCZ_ECOLI http://www.uniprot.org/uniprot/YFCZ_ECOLI UniProtKB-AC P0AD33 http://www.uniprot.org/uniprot/P0AD33 charge swissprot:YFCZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFCZ_ECOLI eggNOG COG3691 http://eggnogapi.embl.de/nog_data/html/tree/COG3691 eggNOG ENOG4105KZW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KZW epestfind swissprot:YFCZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFCZ_ECOLI garnier swissprot:YFCZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFCZ_ECOLI helixturnhelix swissprot:YFCZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFCZ_ECOLI hmoment swissprot:YFCZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFCZ_ECOLI iep swissprot:YFCZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFCZ_ECOLI inforesidue swissprot:YFCZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFCZ_ECOLI octanol swissprot:YFCZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFCZ_ECOLI pepcoil swissprot:YFCZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFCZ_ECOLI pepdigest swissprot:YFCZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFCZ_ECOLI pepinfo swissprot:YFCZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFCZ_ECOLI pepnet swissprot:YFCZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFCZ_ECOLI pepstats swissprot:YFCZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFCZ_ECOLI pepwheel swissprot:YFCZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFCZ_ECOLI pepwindow swissprot:YFCZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFCZ_ECOLI sigcleave swissprot:YFCZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFCZ_ECOLI ## Database ID URL or Descriptions # BRENDA 2.7.13 2026 # BioGrid 4259925 7 # CATALYTIC ACTIVITY KDPD_ECOLI ATP + protein L-histidine = ADP + protein N- phospho-L-histidine. # EcoGene EG10516 kdpD # FUNCTION KDPD_ECOLI Member of the two-component regulatory system KdpD/KdpE involved in the regulation of the kdp operon. KdpD may function as a membrane-associated protein kinase that phosphorylates KdpE in response to environmental signals. {ECO 0000269|PubMed 1532388}. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_component GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane; IDA:EcoCyc. # GO_function GO:0000155 phosphorelay sensor kinase activity; IDA:EcoCyc. # GO_function GO:0004072 aspartate kinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0007234 osmosensory signaling via phosphorelay pathway; IDA:EcoCyc. # GO_process GO:0009593 detection of chemical stimulus; IDA:EcoCyc. # GO_process GO:0046777 protein autophosphorylation; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005622 intracellular # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # Gene3D 1.10.287.130 -; 1. # Gene3D 3.30.565.10 -; 1. # Gene3D 3.40.50.300 -; 1. # Gene3D 3.40.50.620 -; 1. # INTERACTION KDPD_ECOLI P21866 kdpE; NbExp=5; IntAct=EBI-1123100, EBI-6403634; P69829 ptsN; NbExp=4; IntAct=EBI-1123100, EBI-547017; # IntAct P21865 5 # InterPro IPR003018 GAF # InterPro IPR003594 HATPase_C # InterPro IPR003661 HisK_dim/P # InterPro IPR003852 Sig_transdc_His_kinase_KdpD_N # InterPro IPR004358 Sig_transdc_His_kin-like_C # InterPro IPR005467 His_kinase_dom # InterPro IPR014729 Rossmann-like_a/b/a_fold # InterPro IPR025201 KdpD_TM # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01001 Protein kinases # KEGG_Brite ko02022 M00454 KdpD-KdpE (potassium transport) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # Organism KDPD_ECOLI Escherichia coli (strain K12) # PATRIC 32116585 VBIEscCol129921_0725 # PDB 2KSF NMR; -; A=397-502 # PDB 4QPR X-ray; 1.55 A; A=515-646 # PDB 4Y2F X-ray; 1.40 A; A=515-646 # PIR B42372 B42372 # PRINTS PR00344 BCTRLSENSOR # PROSITE PS50109 HIS_KIN # Pfam PF00512 HisKA # Pfam PF02518 HATPase_c # Pfam PF02702 KdpD # Pfam PF13492 GAF_3 # Pfam PF13493 DUF4118 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName KDPD_ECOLI Sensor protein KdpD # RefSeq NP_415223 NC_000913.3 # RefSeq WP_001310640 NZ_LN832404.1 # SIMILARITY Contains 1 histidine kinase domain. {ECO:0000255|PROSITE-ProRule PRU00107}. # SIMILARITY In the central section; belongs to the universal stress protein A family. {ECO 0000305}. # SMART SM00387 HATPase_c # SMART SM00388 HisKA # SUBCELLULAR LOCATION KDPD_ECOLI Cell inner membrane {ECO 0000269|PubMed 1532388}; Multi-pass membrane protein {ECO 0000269|PubMed 1532388}. # SUPFAM SSF47384 SSF47384 # SUPFAM SSF55874 SSF55874 # eggNOG COG2205 LUCA # eggNOG ENOG4105C08 Bacteria BLAST swissprot:KDPD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:KDPD_ECOLI BioCyc ECOL316407:JW0683-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0683-MONOMER BioCyc EcoCyc:KDPD-MONOMER http://biocyc.org/getid?id=EcoCyc:KDPD-MONOMER COG COG2205 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2205 DIP DIP-10062N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10062N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.270.47.28282 http://dx.doi.org/10.1074/jbc.270.47.28282 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.13.3 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.13.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M36066 http://www.ebi.ac.uk/ena/data/view/M36066 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.13.3 http://enzyme.expasy.org/EC/2.7.13.3 EchoBASE EB0511 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0511 EcoGene EG10516 http://www.ecogene.org/geneInfo.php?eg_id=EG10516 EnsemblBacteria AAC73789 http://www.ensemblgenomes.org/id/AAC73789 EnsemblBacteria AAC73789 http://www.ensemblgenomes.org/id/AAC73789 EnsemblBacteria BAA35352 http://www.ensemblgenomes.org/id/BAA35352 EnsemblBacteria BAA35352 http://www.ensemblgenomes.org/id/BAA35352 EnsemblBacteria BAA35352 http://www.ensemblgenomes.org/id/BAA35352 EnsemblBacteria b0695 http://www.ensemblgenomes.org/id/b0695 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0031235 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031235 GO_function GO:0000155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000155 GO_function GO:0004072 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004072 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0007234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007234 GO_process GO:0009593 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009593 GO_process GO:0046777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046777 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.10.287.130 http://www.cathdb.info/version/latest/superfamily/1.10.287.130 Gene3D 3.30.565.10 http://www.cathdb.info/version/latest/superfamily/3.30.565.10 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 GeneID 946744 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946744 HOGENOM HOG000082933 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000082933&db=HOGENOM6 InParanoid P21865 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P21865 IntAct P21865 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P21865* IntEnz 2.7.13.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.13.3 InterPro IPR003018 http://www.ebi.ac.uk/interpro/entry/IPR003018 InterPro IPR003594 http://www.ebi.ac.uk/interpro/entry/IPR003594 InterPro IPR003661 http://www.ebi.ac.uk/interpro/entry/IPR003661 InterPro IPR003852 http://www.ebi.ac.uk/interpro/entry/IPR003852 InterPro IPR004358 http://www.ebi.ac.uk/interpro/entry/IPR004358 InterPro IPR005467 http://www.ebi.ac.uk/interpro/entry/IPR005467 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 InterPro IPR025201 http://www.ebi.ac.uk/interpro/entry/IPR025201 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01001 http://www.genome.jp/dbget-bin/www_bget?ko01001 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW0683 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0683 KEGG_Gene eco:b0695 http://www.genome.jp/dbget-bin/www_bget?eco:b0695 KEGG_Orthology KO:K07646 http://www.genome.jp/dbget-bin/www_bget?KO:K07646 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA LWATAFQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LWATAFQ PDB 2KSF http://www.ebi.ac.uk/pdbe-srv/view/entry/2KSF PDB 4QPR http://www.ebi.ac.uk/pdbe-srv/view/entry/4QPR PDB 4Y2F http://www.ebi.ac.uk/pdbe-srv/view/entry/4Y2F PDBsum 2KSF http://www.ebi.ac.uk/pdbsum/2KSF PDBsum 4QPR http://www.ebi.ac.uk/pdbsum/4QPR PDBsum 4Y2F http://www.ebi.ac.uk/pdbsum/4Y2F PRINTS PR00344 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00344 PROSITE PS50109 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50109 PSORT swissprot:KDPD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:KDPD_ECOLI PSORT-B swissprot:KDPD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:KDPD_ECOLI PSORT2 swissprot:KDPD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:KDPD_ECOLI Pfam PF00512 http://pfam.xfam.org/family/PF00512 Pfam PF02518 http://pfam.xfam.org/family/PF02518 Pfam PF02702 http://pfam.xfam.org/family/PF02702 Pfam PF13492 http://pfam.xfam.org/family/PF13492 Pfam PF13493 http://pfam.xfam.org/family/PF13493 Phobius swissprot:KDPD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:KDPD_ECOLI PhylomeDB P21865 http://phylomedb.org/?seqid=P21865 ProteinModelPortal P21865 http://www.proteinmodelportal.org/query/uniprot/P21865 PubMed 1532388 http://www.ncbi.nlm.nih.gov/pubmed/1532388 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7499326 http://www.ncbi.nlm.nih.gov/pubmed/7499326 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415223 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415223 RefSeq WP_001310640 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001310640 SMART SM00387 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00387 SMART SM00388 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00388 SMR P21865 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P21865 STRING 511145.b0695 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0695&targetmode=cogs STRING COG2205 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2205&targetmode=cogs SUPFAM SSF47384 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47384 SUPFAM SSF55874 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55874 UniProtKB KDPD_ECOLI http://www.uniprot.org/uniprot/KDPD_ECOLI UniProtKB-AC P21865 http://www.uniprot.org/uniprot/P21865 charge swissprot:KDPD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:KDPD_ECOLI eggNOG COG2205 http://eggnogapi.embl.de/nog_data/html/tree/COG2205 eggNOG ENOG4105C08 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C08 epestfind swissprot:KDPD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:KDPD_ECOLI garnier swissprot:KDPD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:KDPD_ECOLI helixturnhelix swissprot:KDPD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:KDPD_ECOLI hmoment swissprot:KDPD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:KDPD_ECOLI iep swissprot:KDPD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:KDPD_ECOLI inforesidue swissprot:KDPD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:KDPD_ECOLI octanol swissprot:KDPD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:KDPD_ECOLI pepcoil swissprot:KDPD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:KDPD_ECOLI pepdigest swissprot:KDPD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:KDPD_ECOLI pepinfo swissprot:KDPD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:KDPD_ECOLI pepnet swissprot:KDPD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:KDPD_ECOLI pepstats swissprot:KDPD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:KDPD_ECOLI pepwheel swissprot:KDPD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:KDPD_ECOLI pepwindow swissprot:KDPD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:KDPD_ECOLI sigcleave swissprot:KDPD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:KDPD_ECOLI ## Database ID URL or Descriptions # BioGrid 4259322 5 # CAUTION Despite its homology to the anaerobic sulfatase- maturating enzymes, it is not involved in Cys-type sulfatase maturation in vivo. {ECO 0000305}. # COFACTOR ASLB_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000250}; Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. {ECO 0000250}; # COFACTOR ASLB_ECOLI Name=iron-sulfur cluster; Xref=ChEBI CHEBI 30408; Evidence={ECO 0000305}; Note=May bind at least one other iron-sulfur cluster. {ECO 0000305}; # EcoGene EG10090 aslB # GO_function GO:0016491 oxidoreductase activity; IEA:InterPro. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0051604 protein maturation; ISS:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0051604 protein maturation # Gene3D 3.20.20.70 -; 1. # InterPro IPR007197 rSAM # InterPro IPR013785 Aldolase_TIM # InterPro IPR023867 Sulphatase_maturase_rSAM # InterPro IPR023885 4Fe4S-binding_SPASM_dom # Organism ASLB_ECOLI Escherichia coli (strain K12) # PATRIC 32123097 VBIEscCol129921_3914 # PIR A65184 A65184 # Pfam PF04055 Radical_SAM # Pfam PF13186 SPASM # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ASLB_ECOLI Anaerobic sulfatase-maturating enzyme homolog AslB # RefSeq WP_000941517 NZ_LN832404.1 # RefSeq YP_026259 NC_000913.3 # SIMILARITY Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family. {ECO 0000305}. # TIGRFAMs TIGR03942 sulfatase_rSAM # TIGRFAMs TIGR04085 rSAM_more_4Fe4S # eggNOG COG0641 LUCA # eggNOG ENOG4105C4X Bacteria BLAST swissprot:ASLB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ASLB_ECOLI BioCyc ECOL316407:JW5594-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5594-MONOMER BioCyc EcoCyc:EG10090-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10090-MONOMER COG COG0641 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0641 DOI 10.1016/j.febslet.2007.01.076 http://dx.doi.org/10.1016/j.febslet.2007.01.076 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/29.5.1097 http://dx.doi.org/10.1093/nar/29.5.1097 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL M90498 http://www.ebi.ac.uk/ena/data/view/M90498 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0088 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0088 EcoGene EG10090 http://www.ecogene.org/geneInfo.php?eg_id=EG10090 EnsemblBacteria AAT48217 http://www.ensemblgenomes.org/id/AAT48217 EnsemblBacteria AAT48217 http://www.ensemblgenomes.org/id/AAT48217 EnsemblBacteria BAE77501 http://www.ensemblgenomes.org/id/BAE77501 EnsemblBacteria BAE77501 http://www.ensemblgenomes.org/id/BAE77501 EnsemblBacteria BAE77501 http://www.ensemblgenomes.org/id/BAE77501 EnsemblBacteria b3800 http://www.ensemblgenomes.org/id/b3800 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 949013 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949013 HOGENOM HOG000000300 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000000300&db=HOGENOM6 InParanoid P25550 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P25550 InterPro IPR007197 http://www.ebi.ac.uk/interpro/entry/IPR007197 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR023867 http://www.ebi.ac.uk/interpro/entry/IPR023867 InterPro IPR023885 http://www.ebi.ac.uk/interpro/entry/IPR023885 KEGG_Gene ecj:JW5594 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5594 KEGG_Gene eco:b3800 http://www.genome.jp/dbget-bin/www_bget?eco:b3800 KEGG_Orthology KO:K06871 http://www.genome.jp/dbget-bin/www_bget?KO:K06871 OMA EHNGDLY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EHNGDLY PSORT swissprot:ASLB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ASLB_ECOLI PSORT-B swissprot:ASLB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ASLB_ECOLI PSORT2 swissprot:ASLB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ASLB_ECOLI Pfam PF04055 http://pfam.xfam.org/family/PF04055 Pfam PF13186 http://pfam.xfam.org/family/PF13186 Phobius swissprot:ASLB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ASLB_ECOLI PhylomeDB P25550 http://phylomedb.org/?seqid=P25550 ProteinModelPortal P25550 http://www.proteinmodelportal.org/query/uniprot/P25550 PubMed 11222759 http://www.ncbi.nlm.nih.gov/pubmed/11222759 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17303125 http://www.ncbi.nlm.nih.gov/pubmed/17303125 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000941517 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000941517 RefSeq YP_026259 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026259 SMR P25550 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P25550 STRING 511145.b3800 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3800&targetmode=cogs STRING COG0641 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0641&targetmode=cogs TIGRFAMs TIGR03942 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03942 TIGRFAMs TIGR04085 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR04085 UniProtKB ASLB_ECOLI http://www.uniprot.org/uniprot/ASLB_ECOLI UniProtKB-AC P25550 http://www.uniprot.org/uniprot/P25550 charge swissprot:ASLB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ASLB_ECOLI eggNOG COG0641 http://eggnogapi.embl.de/nog_data/html/tree/COG0641 eggNOG ENOG4105C4X http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C4X epestfind swissprot:ASLB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ASLB_ECOLI garnier swissprot:ASLB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ASLB_ECOLI helixturnhelix swissprot:ASLB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ASLB_ECOLI hmoment swissprot:ASLB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ASLB_ECOLI iep swissprot:ASLB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ASLB_ECOLI inforesidue swissprot:ASLB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ASLB_ECOLI octanol swissprot:ASLB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ASLB_ECOLI pepcoil swissprot:ASLB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ASLB_ECOLI pepdigest swissprot:ASLB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ASLB_ECOLI pepinfo swissprot:ASLB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ASLB_ECOLI pepnet swissprot:ASLB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ASLB_ECOLI pepstats swissprot:ASLB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ASLB_ECOLI pepwheel swissprot:ASLB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ASLB_ECOLI pepwindow swissprot:ASLB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ASLB_ECOLI sigcleave swissprot:ASLB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ASLB_ECOLI ## Database ID URL or Descriptions # BioGrid 4262695 235 # COFACTOR Name=FAD; Xref=ChEBI:CHEBI 57692; # DOMAIN AIDB_ECOLI The N-terminal region contains FAD-dependent dehydrogenase activity and the C-terminal region contains DNA-binding activity. {ECO 0000269|PubMed 20889740}. # EcoGene EG11811 aidB # FUNCTION AIDB_ECOLI Part of the adaptive DNA-repair response to alkylating agents. Could prevent alkylation damage by protecting DNA and destroying alkylating agents that have yet to reach their DNA target. Binds to double-stranded DNA with a preference for a DNA region that includes its own promoter. Shows weak isovaleryl-CoA dehydrogenase activity in vitro. {ECO 0000269|PubMed 16352838, ECO 0000269|PubMed 18829440, ECO 0000269|PubMed 7961409}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0000062 fatty-acyl-CoA binding; IBA:GO_Central. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0008470 isovaleryl-CoA dehydrogenase activity; IDA:EcoCyc. # GO_function GO:0009055 electron carrier activity; IBA:GO_Central. # GO_function GO:0043565 sequence-specific DNA binding; IDA:EcoCyc. # GO_function GO:0050660 flavin adenine dinucleotide binding; IBA:GO_Central. # GO_function GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor; IBA:GO_Central. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoCyc. # GO_process GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase; IBA:GO_Central. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0055088 lipid homeostasis; IBA:GO_Central. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0042592 homeostatic process # GOslim_process GO:0044281 small molecule metabolic process # INDUCTION AIDB_ECOLI Regulated by Ada in response to alkylating agents. Also induced by anaerobiosis or by acetate at pH 6.5, via RpoS. Represses its own synthesis during normal cell growth. {ECO 0000269|PubMed 20889740, ECO 0000269|PubMed 7961409}. # IntAct P33224 32 # InterPro IPR006089 Acyl-CoA_DH_CS # InterPro IPR006091 Acyl-CoA_Oxase/DH_cen-dom # InterPro IPR009075 AcylCo_DH/oxidase_C # InterPro IPR009100 AcylCoA_DH/oxidase_NM_dom # Organism AIDB_ECOLI Escherichia coli (strain K12) # PATRIC 32123949 VBIEscCol129921_4319 # PDB 3DJL X-ray; 1.70 A; A=1-541 # PDB 3U33 X-ray; 2.80 A; A/B/C/D/E/F/G/H/I/J/K/L=1-541 # PIR I41124 I41124 # PROSITE PS00072 ACYL_COA_DH_1 # PROSITE PS00073 ACYL_COA_DH_2 # Pfam PF00441 Acyl-CoA_dh_1 # Pfam PF02770 Acyl-CoA_dh_M # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AIDB_ECOLI Putative acyl-CoA dehydrogenase AidB # RefSeq NP_418608 NC_000913.3 # RefSeq WP_001350567 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97083.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAC18889.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the acyl-CoA dehydrogenase family. {ECO 0000305}. # SUBCELLULAR LOCATION AIDB_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT AIDB_ECOLI Homotetramer. Dimer of dimers. {ECO 0000269|PubMed 16352838, ECO 0000269|PubMed 18829440}. # SUPFAM SSF47203 SSF47203 # SUPFAM SSF56645 SSF56645 # eggNOG COG1960 LUCA # eggNOG ENOG4105CSU Bacteria BLAST swissprot:AIDB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AIDB_ECOLI BioCyc ECOL316407:JW5867-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5867-MONOMER BioCyc EcoCyc:EG11811-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11811-MONOMER BioCyc MetaCyc:EG11811-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11811-MONOMER COG COG1960 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1960 DIP DIP-9078N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9078N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0806521105 http://dx.doi.org/10.1073/pnas.0806521105 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00858-10 http://dx.doi.org/10.1128/JB.00858-10 DOI 10.1128/JB.188.1.223-230.2006 http://dx.doi.org/10.1128/JB.188.1.223-230.2006 EC_number EC:1.3.99.- http://www.genome.jp/dbget-bin/www_bget?EC:1.3.99.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L20915 http://www.ebi.ac.uk/ena/data/view/L20915 EMBL L20915 http://www.ebi.ac.uk/ena/data/view/L20915 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 1.3.99.- http://enzyme.expasy.org/EC/1.3.99.- EchoBASE EB1759 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1759 EcoGene EG11811 http://www.ecogene.org/geneInfo.php?eg_id=EG11811 EnsemblBacteria AAC77144 http://www.ensemblgenomes.org/id/AAC77144 EnsemblBacteria AAC77144 http://www.ensemblgenomes.org/id/AAC77144 EnsemblBacteria BAE78188 http://www.ensemblgenomes.org/id/BAE78188 EnsemblBacteria BAE78188 http://www.ensemblgenomes.org/id/BAE78188 EnsemblBacteria BAE78188 http://www.ensemblgenomes.org/id/BAE78188 EnsemblBacteria b4187 http://www.ensemblgenomes.org/id/b4187 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000062 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000062 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0008470 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008470 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_function GO:0052890 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052890 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0033539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033539 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GO_process GO:0055088 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055088 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 948710 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948710 HOGENOM HOG000253935 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000253935&db=HOGENOM6 InParanoid P33224 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33224 IntAct P33224 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33224* IntEnz 1.3.99 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.3.99 InterPro IPR006089 http://www.ebi.ac.uk/interpro/entry/IPR006089 InterPro IPR006091 http://www.ebi.ac.uk/interpro/entry/IPR006091 InterPro IPR009075 http://www.ebi.ac.uk/interpro/entry/IPR009075 InterPro IPR009100 http://www.ebi.ac.uk/interpro/entry/IPR009100 KEGG_Gene ecj:JW5867 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5867 KEGG_Gene eco:b4187 http://www.genome.jp/dbget-bin/www_bget?eco:b4187 KEGG_Orthology KO:K09456 http://www.genome.jp/dbget-bin/www_bget?KO:K09456 MINT MINT-1221527 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1221527 OMA TLCPITM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TLCPITM PDB 3DJL http://www.ebi.ac.uk/pdbe-srv/view/entry/3DJL PDB 3U33 http://www.ebi.ac.uk/pdbe-srv/view/entry/3U33 PDBsum 3DJL http://www.ebi.ac.uk/pdbsum/3DJL PDBsum 3U33 http://www.ebi.ac.uk/pdbsum/3U33 PROSITE PS00072 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00072 PROSITE PS00073 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00073 PSORT swissprot:AIDB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AIDB_ECOLI PSORT-B swissprot:AIDB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AIDB_ECOLI PSORT2 swissprot:AIDB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AIDB_ECOLI Pfam PF00441 http://pfam.xfam.org/family/PF00441 Pfam PF02770 http://pfam.xfam.org/family/PF02770 Phobius swissprot:AIDB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AIDB_ECOLI PhylomeDB P33224 http://phylomedb.org/?seqid=P33224 ProteinModelPortal P33224 http://www.proteinmodelportal.org/query/uniprot/P33224 PubMed 16352838 http://www.ncbi.nlm.nih.gov/pubmed/16352838 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18829440 http://www.ncbi.nlm.nih.gov/pubmed/18829440 PubMed 20889740 http://www.ncbi.nlm.nih.gov/pubmed/20889740 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 7961409 http://www.ncbi.nlm.nih.gov/pubmed/7961409 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418608 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418608 RefSeq WP_001350567 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001350567 SMR P33224 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33224 STRING 511145.b4187 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4187&targetmode=cogs STRING COG1960 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1960&targetmode=cogs SUPFAM SSF47203 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47203 SUPFAM SSF56645 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56645 UniProtKB AIDB_ECOLI http://www.uniprot.org/uniprot/AIDB_ECOLI UniProtKB-AC P33224 http://www.uniprot.org/uniprot/P33224 charge swissprot:AIDB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AIDB_ECOLI eggNOG COG1960 http://eggnogapi.embl.de/nog_data/html/tree/COG1960 eggNOG ENOG4105CSU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CSU epestfind swissprot:AIDB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AIDB_ECOLI garnier swissprot:AIDB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AIDB_ECOLI helixturnhelix swissprot:AIDB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AIDB_ECOLI hmoment swissprot:AIDB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AIDB_ECOLI iep swissprot:AIDB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AIDB_ECOLI inforesidue swissprot:AIDB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AIDB_ECOLI octanol swissprot:AIDB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AIDB_ECOLI pepcoil swissprot:AIDB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AIDB_ECOLI pepdigest swissprot:AIDB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AIDB_ECOLI pepinfo swissprot:AIDB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AIDB_ECOLI pepnet swissprot:AIDB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AIDB_ECOLI pepstats swissprot:AIDB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AIDB_ECOLI pepwheel swissprot:AIDB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AIDB_ECOLI pepwindow swissprot:AIDB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AIDB_ECOLI sigcleave swissprot:AIDB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AIDB_ECOLI ## Database ID URL or Descriptions # AltName UVRC_ECOLI Excinuclease ABC subunit C # BioGrid 4260379 105 # EcoGene EG11063 uvrC # FUNCTION UVRC_ECOLI The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. {ECO 0000269|PubMed 10671556, ECO 0000269|PubMed 1387639}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_component GO:0009380 excinuclease repair complex; IDA:UniProtKB. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0009381 excinuclease ABC activity; IEA:UniProtKB-HAMAP. # GO_process GO:0006289 nucleotide-excision repair; IEA:UniProtKB-HAMAP. # GO_process GO:0006974 cellular response to DNA damage stimulus; IBA:GO_Central. # GO_process GO:0009432 SOS response; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004518 nuclease activity # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # Gene3D 3.40.1440.10 -; 1. # Gene3D 4.10.860.10 -; 1. # HAMAP MF_00203 UvrC # IntAct P0A8G0 45 # InterPro IPR000305 GIY-YIG_SF # InterPro IPR001162 UvrC_homol_region # InterPro IPR001943 UVR_dom # InterPro IPR003583 Hlx-hairpin-Hlx_DNA-bd_motif # InterPro IPR004791 UvrC # InterPro IPR010994 RuvA_2-like # InterPro IPR027299 GIY-YIG_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko03420 Nucleotide excision repair # Organism UVRC_ECOLI Escherichia coli (strain K12) # PATRIC 32119159 VBIEscCol129921_1994 # PDB 1KFT NMR; -; A=554-610 # PIR F64954 BVECUC # PROSITE PS50151 UVR # PROSITE PS50164 GIY_YIG # PROSITE PS50165 UVRC # Pfam PF01541 GIY-YIG # Pfam PF02151 UVR # Pfam PF08459 UvrC_HhH_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UVRC_ECOLI UvrABC system protein C # RefSeq NP_416423 NC_000913.3 # RefSeq WP_001283421 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA27329.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the UvrC family. {ECO 0000305}. # SIMILARITY Contains 1 GIY-YIG domain. {ECO 0000305}. # SIMILARITY Contains 1 UVR domain. {ECO 0000305}. # SMART SM00278 HhH1; 2 # SMART SM00465 GIYc # SUBCELLULAR LOCATION UVRC_ECOLI Cytoplasm. # SUBUNIT UVRC_ECOLI Interacts with UvrB in an incision complex. # SUPFAM SSF46600 SSF46600 # SUPFAM SSF47781 SSF47781 # SUPFAM SSF82771 SSF82771 # TIGRFAMs TIGR00194 uvrC # eggNOG COG0322 LUCA # eggNOG ENOG4105CII Bacteria BLAST swissprot:UVRC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UVRC_ECOLI BioCyc ECOL316407:JW1898-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1898-MONOMER BioCyc EcoCyc:EG11063-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11063-MONOMER BioCyc MetaCyc:EG11063-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11063-MONOMER COG COG0322 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0322 DIP DIP-47875N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47875N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.275.7.5120 http://dx.doi.org/10.1074/jbc.275.7.5120 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/nar/12.11.4593 http://dx.doi.org/10.1093/nar/12.11.4593 DOI 10.1093/nar/14.5.2301 http://dx.doi.org/10.1093/nar/14.5.2301 DOI 10.1093/nar/15.10.4273 http://dx.doi.org/10.1093/nar/15.10.4273 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M12299 http://www.ebi.ac.uk/ena/data/view/M12299 EMBL M24615 http://www.ebi.ac.uk/ena/data/view/M24615 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X03691 http://www.ebi.ac.uk/ena/data/view/X03691 EMBL X05398 http://www.ebi.ac.uk/ena/data/view/X05398 EchoBASE EB1056 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1056 EcoGene EG11063 http://www.ecogene.org/geneInfo.php?eg_id=EG11063 EnsemblBacteria AAC74980 http://www.ensemblgenomes.org/id/AAC74980 EnsemblBacteria AAC74980 http://www.ensemblgenomes.org/id/AAC74980 EnsemblBacteria BAA15733 http://www.ensemblgenomes.org/id/BAA15733 EnsemblBacteria BAA15733 http://www.ensemblgenomes.org/id/BAA15733 EnsemblBacteria BAA15733 http://www.ensemblgenomes.org/id/BAA15733 EnsemblBacteria b1913 http://www.ensemblgenomes.org/id/b1913 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0009380 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009380 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0009381 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009381 GO_process GO:0006289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006289 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0009432 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009432 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.40.1440.10 http://www.cathdb.info/version/latest/superfamily/3.40.1440.10 Gene3D 4.10.860.10 http://www.cathdb.info/version/latest/superfamily/4.10.860.10 GeneID 947203 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947203 HAMAP MF_00203 http://hamap.expasy.org/unirule/MF_00203 HOGENOM HOG000279961 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000279961&db=HOGENOM6 InParanoid P0A8G0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8G0 IntAct P0A8G0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8G0* InterPro IPR000305 http://www.ebi.ac.uk/interpro/entry/IPR000305 InterPro IPR001162 http://www.ebi.ac.uk/interpro/entry/IPR001162 InterPro IPR001943 http://www.ebi.ac.uk/interpro/entry/IPR001943 InterPro IPR003583 http://www.ebi.ac.uk/interpro/entry/IPR003583 InterPro IPR004791 http://www.ebi.ac.uk/interpro/entry/IPR004791 InterPro IPR010994 http://www.ebi.ac.uk/interpro/entry/IPR010994 InterPro IPR027299 http://www.ebi.ac.uk/interpro/entry/IPR027299 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW1898 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1898 KEGG_Gene eco:b1913 http://www.genome.jp/dbget-bin/www_bget?eco:b1913 KEGG_Orthology KO:K03703 http://www.genome.jp/dbget-bin/www_bget?KO:K03703 KEGG_Pathway ko03420 http://www.genome.jp/kegg-bin/show_pathway?ko03420 MINT MINT-1221235 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1221235 OMA RCPGVCQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RCPGVCQ PDB 1KFT http://www.ebi.ac.uk/pdbe-srv/view/entry/1KFT PDBsum 1KFT http://www.ebi.ac.uk/pdbsum/1KFT PROSITE PS50151 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50151 PROSITE PS50164 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50164 PROSITE PS50165 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50165 PSORT swissprot:UVRC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UVRC_ECOLI PSORT-B swissprot:UVRC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UVRC_ECOLI PSORT2 swissprot:UVRC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UVRC_ECOLI Pfam PF01541 http://pfam.xfam.org/family/PF01541 Pfam PF02151 http://pfam.xfam.org/family/PF02151 Pfam PF08459 http://pfam.xfam.org/family/PF08459 Phobius swissprot:UVRC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UVRC_ECOLI PhylomeDB P0A8G0 http://phylomedb.org/?seqid=P0A8G0 ProteinModelPortal P0A8G0 http://www.proteinmodelportal.org/query/uniprot/P0A8G0 PubMed 10671556 http://www.ncbi.nlm.nih.gov/pubmed/10671556 PubMed 1387639 http://www.ncbi.nlm.nih.gov/pubmed/1387639 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3003065 http://www.ncbi.nlm.nih.gov/pubmed/3003065 PubMed 3295776 http://www.ncbi.nlm.nih.gov/pubmed/3295776 PubMed 3515318 http://www.ncbi.nlm.nih.gov/pubmed/3515318 PubMed 6330676 http://www.ncbi.nlm.nih.gov/pubmed/6330676 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_416423 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416423 RefSeq WP_001283421 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001283421 SMART SM00278 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00278 SMART SM00465 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00465 SMR P0A8G0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8G0 STRING 511145.b1913 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1913&targetmode=cogs STRING COG0322 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0322&targetmode=cogs SUPFAM SSF46600 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46600 SUPFAM SSF47781 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47781 SUPFAM SSF82771 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF82771 TIGRFAMs TIGR00194 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00194 UniProtKB UVRC_ECOLI http://www.uniprot.org/uniprot/UVRC_ECOLI UniProtKB-AC P0A8G0 http://www.uniprot.org/uniprot/P0A8G0 charge swissprot:UVRC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UVRC_ECOLI eggNOG COG0322 http://eggnogapi.embl.de/nog_data/html/tree/COG0322 eggNOG ENOG4105CII http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CII epestfind swissprot:UVRC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UVRC_ECOLI garnier swissprot:UVRC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UVRC_ECOLI helixturnhelix swissprot:UVRC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UVRC_ECOLI hmoment swissprot:UVRC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UVRC_ECOLI iep swissprot:UVRC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UVRC_ECOLI inforesidue swissprot:UVRC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UVRC_ECOLI octanol swissprot:UVRC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UVRC_ECOLI pepcoil swissprot:UVRC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UVRC_ECOLI pepdigest swissprot:UVRC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UVRC_ECOLI pepinfo swissprot:UVRC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UVRC_ECOLI pepnet swissprot:UVRC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UVRC_ECOLI pepstats swissprot:UVRC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UVRC_ECOLI pepwheel swissprot:UVRC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UVRC_ECOLI pepwindow swissprot:UVRC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UVRC_ECOLI sigcleave swissprot:UVRC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UVRC_ECOLI ## Database ID URL or Descriptions # BioGrid 4262360 55 # EcoGene EG12984 yggX # FUNCTION FETP_ECOLI Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes. Necessary to maintain high levels of aconitase under oxidative stress. {ECO 0000269|PubMed 14594836, ECO 0000269|PubMed 15883188}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0005506 iron ion binding; IEA:UniProtKB-HAMAP. # GO_process GO:0034599 cellular response to oxidative stress; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # HAMAP MF_00686 Fe_traffic_YggX # INDUCTION By oxidative stress and SoxS. {ECO:0000269|PubMed 14594836}. # IntAct P0A8P3 3 # InterPro IPR007457 Fe_traffick_prot_YggX # Organism FETP_ECOLI Escherichia coli (strain K12) # PATRIC 32121338 VBIEscCol129921_3057 # PDB 1YHD NMR; -; A=2-91 # PIR A65082 A65082 # PIRSF PIRSF029827 Fe_traffic_YggX # Pfam PF04362 Iron_traffic # ProDom PD029191 Fe_traffick_prot_YggX # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FETP_ECOLI Probable Fe(2+)-trafficking protein # RefSeq NP_417437 NC_000913.3 # RefSeq WP_000091700 NZ_LN832404.1 # SIMILARITY Belongs to the Fe(2+)-trafficking protein family. {ECO 0000305}. # SUBUNIT Monomer. {ECO 0000305}. # SUPFAM SSF111148 SSF111148 # eggNOG COG2924 LUCA # eggNOG ENOG4105KMG Bacteria BLAST swissprot:FETP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FETP_ECOLI BioCyc ECOL316407:JW2929-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2929-MONOMER BioCyc EcoCyc:G7532-MONOMER http://biocyc.org/getid?id=EcoCyc:G7532-MONOMER DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1110/ps.051358105 http://dx.doi.org/10.1110/ps.051358105 DOI 10.1111/j.1574-6968.1998.tb13343.x http://dx.doi.org/10.1111/j.1574-6968.1998.tb13343.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.185.22.6624-6632.2003 http://dx.doi.org/10.1128/JB.185.22.6624-6632.2003 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2809 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2809 EcoGene EG12984 http://www.ecogene.org/geneInfo.php?eg_id=EG12984 EnsemblBacteria AAC75999 http://www.ensemblgenomes.org/id/AAC75999 EnsemblBacteria AAC75999 http://www.ensemblgenomes.org/id/AAC75999 EnsemblBacteria BAE77025 http://www.ensemblgenomes.org/id/BAE77025 EnsemblBacteria BAE77025 http://www.ensemblgenomes.org/id/BAE77025 EnsemblBacteria BAE77025 http://www.ensemblgenomes.org/id/BAE77025 EnsemblBacteria b2962 http://www.ensemblgenomes.org/id/b2962 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_process GO:0034599 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034599 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 947461 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947461 HAMAP MF_00686 http://hamap.expasy.org/unirule/MF_00686 HOGENOM HOG000137239 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000137239&db=HOGENOM6 InParanoid P0A8P3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8P3 IntAct P0A8P3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8P3* InterPro IPR007457 http://www.ebi.ac.uk/interpro/entry/IPR007457 KEGG_Gene ecj:JW2929 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2929 KEGG_Gene eco:b2962 http://www.genome.jp/dbget-bin/www_bget?eco:b2962 MINT MINT-1253097 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1253097 OMA SKQTMLI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SKQTMLI PDB 1YHD http://www.ebi.ac.uk/pdbe-srv/view/entry/1YHD PDBsum 1YHD http://www.ebi.ac.uk/pdbsum/1YHD PSORT swissprot:FETP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FETP_ECOLI PSORT-B swissprot:FETP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FETP_ECOLI PSORT2 swissprot:FETP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FETP_ECOLI Pfam PF04362 http://pfam.xfam.org/family/PF04362 Phobius swissprot:FETP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FETP_ECOLI PhylomeDB P0A8P3 http://phylomedb.org/?seqid=P0A8P3 ProteinModelPortal P0A8P3 http://www.proteinmodelportal.org/query/uniprot/P0A8P3 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 14594836 http://www.ncbi.nlm.nih.gov/pubmed/14594836 PubMed 15883188 http://www.ncbi.nlm.nih.gov/pubmed/15883188 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9868784 http://www.ncbi.nlm.nih.gov/pubmed/9868784 RefSeq NP_417437 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417437 RefSeq WP_000091700 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000091700 SMR P0A8P3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8P3 STRING 511145.b2962 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2962&targetmode=cogs SUPFAM SSF111148 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF111148 SWISS-2DPAGE P0A8P3 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A8P3 UniProtKB FETP_ECOLI http://www.uniprot.org/uniprot/FETP_ECOLI UniProtKB-AC P0A8P3 http://www.uniprot.org/uniprot/P0A8P3 charge swissprot:FETP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FETP_ECOLI eggNOG COG2924 http://eggnogapi.embl.de/nog_data/html/tree/COG2924 eggNOG ENOG4105KMG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KMG epestfind swissprot:FETP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FETP_ECOLI garnier swissprot:FETP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FETP_ECOLI helixturnhelix swissprot:FETP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FETP_ECOLI hmoment swissprot:FETP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FETP_ECOLI iep swissprot:FETP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FETP_ECOLI inforesidue swissprot:FETP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FETP_ECOLI octanol swissprot:FETP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FETP_ECOLI pepcoil swissprot:FETP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FETP_ECOLI pepdigest swissprot:FETP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FETP_ECOLI pepinfo swissprot:FETP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FETP_ECOLI pepnet swissprot:FETP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FETP_ECOLI pepstats swissprot:FETP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FETP_ECOLI pepwheel swissprot:FETP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FETP_ECOLI pepwindow swissprot:FETP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FETP_ECOLI sigcleave swissprot:FETP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FETP_ECOLI ## Database ID URL or Descriptions # AltName C561_ECOLI Cytochrome b-561 # BIOPHYSICOCHEMICAL PROPERTIES Redox potential E(0) is +20 mV.; # BioGrid 4262882 9 # COFACTOR Name=heme b; Xref=ChEBI:CHEBI 60344; Note=Binds 2 heme B (iron-protoporphyrin IX) groups per molecule.; # EcoGene EG10172 cybB # FUNCTION C561_ECOLI B-type di-heme cytochrome with a major alpha-absorption peak at 561 nm and a minor peak at 555 nm. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0009055 electron carrier activity; IEA:InterPro. # GO_function GO:0020037 heme binding; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0022904 respiratory electron transport chain; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # InterPro IPR011577 Cyt_b561_bac/Ni-Hgenase # InterPro IPR016174 Di-haem_cyt_TM # Organism C561_ECOLI Escherichia coli (strain K12) # PATRIC 32118124 VBIEscCol129921_1482 # Pfam PF01292 Ni_hydr_CYTB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName C561_ECOLI Cytochrome b561 # RefSeq NP_415935 NC_000913.3 # RefSeq WP_000428998 NZ_LN832404.1 # SIMILARITY Belongs to the cytochrome b561 family. {ECO 0000305}. # SUBCELLULAR LOCATION C561_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT C561_ECOLI Monomer. # SUPFAM SSF81342 SSF81342 # eggNOG COG3038 LUCA # eggNOG ENOG4105CPW Bacteria BLAST swissprot:C561_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:C561_ECOLI BioCyc ECOL316407:JW5224-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5224-MONOMER BioCyc EcoCyc:CYTOCHROME-B561-MONOMER http://biocyc.org/getid?id=EcoCyc:CYTOCHROME-B561-MONOMER BioCyc MetaCyc:CYTOCHROME-B561-MONOMER http://biocyc.org/getid?id=MetaCyc:CYTOCHROME-B561-MONOMER COG COG3038 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3038 DOI 10.1007/BF00322437 http://dx.doi.org/10.1007/BF00322437 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X07569 http://www.ebi.ac.uk/ena/data/view/X07569 EchoBASE EB0169 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0169 EcoGene EG10172 http://www.ecogene.org/geneInfo.php?eg_id=EG10172 EnsemblBacteria AAC74500 http://www.ensemblgenomes.org/id/AAC74500 EnsemblBacteria AAC74500 http://www.ensemblgenomes.org/id/AAC74500 EnsemblBacteria BAA15039 http://www.ensemblgenomes.org/id/BAA15039 EnsemblBacteria BAA15039 http://www.ensemblgenomes.org/id/BAA15039 EnsemblBacteria BAA15039 http://www.ensemblgenomes.org/id/BAA15039 EnsemblBacteria b1418 http://www.ensemblgenomes.org/id/b1418 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0020037 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0020037 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0022904 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022904 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GeneID 947241 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947241 HOGENOM HOG000110384 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000110384&db=HOGENOM6 InParanoid P0ABE5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABE5 InterPro IPR011577 http://www.ebi.ac.uk/interpro/entry/IPR011577 InterPro IPR016174 http://www.ebi.ac.uk/interpro/entry/IPR016174 KEGG_Gene ecj:JW5224 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5224 KEGG_Gene eco:b1418 http://www.genome.jp/dbget-bin/www_bget?eco:b1418 KEGG_Orthology KO:K12262 http://www.genome.jp/dbget-bin/www_bget?KO:K12262 OMA FHHYMLG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FHHYMLG PSORT swissprot:C561_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:C561_ECOLI PSORT-B swissprot:C561_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:C561_ECOLI PSORT2 swissprot:C561_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:C561_ECOLI Pfam PF01292 http://pfam.xfam.org/family/PF01292 Phobius swissprot:C561_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:C561_ECOLI PhylomeDB P0ABE5 http://phylomedb.org/?seqid=P0ABE5 ProteinModelPortal P0ABE5 http://www.proteinmodelportal.org/query/uniprot/P0ABE5 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2836696 http://www.ncbi.nlm.nih.gov/pubmed/2836696 PubMed 3510204 http://www.ncbi.nlm.nih.gov/pubmed/3510204 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415935 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415935 RefSeq WP_000428998 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000428998 STRING 511145.b1418 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1418&targetmode=cogs STRING COG3038 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3038&targetmode=cogs SUPFAM SSF81342 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81342 UniProtKB C561_ECOLI http://www.uniprot.org/uniprot/C561_ECOLI UniProtKB-AC P0ABE5 http://www.uniprot.org/uniprot/P0ABE5 charge swissprot:C561_ECOLI http://rest.g-language.org/emboss/charge/swissprot:C561_ECOLI eggNOG COG3038 http://eggnogapi.embl.de/nog_data/html/tree/COG3038 eggNOG ENOG4105CPW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CPW epestfind swissprot:C561_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:C561_ECOLI garnier swissprot:C561_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:C561_ECOLI helixturnhelix swissprot:C561_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:C561_ECOLI hmoment swissprot:C561_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:C561_ECOLI iep swissprot:C561_ECOLI http://rest.g-language.org/emboss/iep/swissprot:C561_ECOLI inforesidue swissprot:C561_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:C561_ECOLI octanol swissprot:C561_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:C561_ECOLI pepcoil swissprot:C561_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:C561_ECOLI pepdigest swissprot:C561_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:C561_ECOLI pepinfo swissprot:C561_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:C561_ECOLI pepnet swissprot:C561_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:C561_ECOLI pepstats swissprot:C561_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:C561_ECOLI pepwheel swissprot:C561_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:C561_ECOLI pepwindow swissprot:C561_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:C561_ECOLI sigcleave swissprot:C561_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:C561_ECOLI ## Database ID URL or Descriptions # BioGrid 4263286 13 # EcoGene EG10974 srlR # GO_component GO:0005622 intracellular; IEA:InterPro. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_component GO:0005622 intracellular # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # INDUCTION SRLR_ECOLI By glucitol. # IntAct P15082 26 # InterPro IPR001034 DeoR_HTH # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR014036 DeoR_C # InterPro IPR018356 Tscrpt_reg_HTH_DeoR_CS # KEGG_Brite ko03000 Transcription factors # Organism SRLR_ECOLI Escherichia coli (strain K12) # PATRIC 32120812 VBIEscCol129921_2798 # PIR S01832 S01832 # PROSITE PS00894 HTH_DEOR_1 # PROSITE PS51000 HTH_DEOR_2 # Pfam PF00455 DeoRC # Pfam PF08220 HTH_DeoR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SRLR_ECOLI Glucitol operon repressor # RefSeq NP_417187 NC_000913.3 # RefSeq WP_000804550 NZ_LN832404.1 # SIMILARITY Contains 1 HTH deoR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00349}. # SMART SM00420 HTH_DEOR # SUPFAM SSF46785 SSF46785 # eggNOG COG1349 LUCA # eggNOG ENOG410804X Bacteria BLAST swissprot:SRLR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SRLR_ECOLI BioCyc ECOL316407:JW2676-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2676-MONOMER BioCyc EcoCyc:PD00283 http://biocyc.org/getid?id=EcoCyc:PD00283 COG COG1349 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1349 DIP DIP-10919N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10919N DOI 10.1016/0022-2836(88)90193-3 http://dx.doi.org/10.1016/0022-2836(88)90193-3 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J02708 http://www.ebi.ac.uk/ena/data/view/J02708 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EMBL X13463 http://www.ebi.ac.uk/ena/data/view/X13463 EchoBASE EB0967 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0967 EcoGene EG10974 http://www.ecogene.org/geneInfo.php?eg_id=EG10974 EnsemblBacteria AAC75749 http://www.ensemblgenomes.org/id/AAC75749 EnsemblBacteria AAC75749 http://www.ensemblgenomes.org/id/AAC75749 EnsemblBacteria BAA16568 http://www.ensemblgenomes.org/id/BAA16568 EnsemblBacteria BAA16568 http://www.ensemblgenomes.org/id/BAA16568 EnsemblBacteria BAA16568 http://www.ensemblgenomes.org/id/BAA16568 EnsemblBacteria b2707 http://www.ensemblgenomes.org/id/b2707 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 948942 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948942 HOGENOM HOG000224684 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000224684&db=HOGENOM6 InParanoid P15082 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P15082 IntAct P15082 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P15082* InterPro IPR001034 http://www.ebi.ac.uk/interpro/entry/IPR001034 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR014036 http://www.ebi.ac.uk/interpro/entry/IPR014036 InterPro IPR018356 http://www.ebi.ac.uk/interpro/entry/IPR018356 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW2676 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2676 KEGG_Gene eco:b2707 http://www.genome.jp/dbget-bin/www_bget?eco:b2707 KEGG_Orthology KO:K02468 http://www.genome.jp/dbget-bin/www_bget?KO:K02468 MINT MINT-1226226 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1226226 OMA RVDIAFI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RVDIAFI PROSITE PS00894 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00894 PROSITE PS51000 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51000 PSORT swissprot:SRLR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SRLR_ECOLI PSORT-B swissprot:SRLR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SRLR_ECOLI PSORT2 swissprot:SRLR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SRLR_ECOLI Pfam PF00455 http://pfam.xfam.org/family/PF00455 Pfam PF08220 http://pfam.xfam.org/family/PF08220 Phobius swissprot:SRLR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SRLR_ECOLI PhylomeDB P15082 http://phylomedb.org/?seqid=P15082 ProteinModelPortal P15082 http://www.proteinmodelportal.org/query/uniprot/P15082 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3062173 http://www.ncbi.nlm.nih.gov/pubmed/3062173 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417187 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417187 RefSeq WP_000804550 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000804550 SMART SM00420 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00420 STRING 511145.b2707 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2707&targetmode=cogs STRING COG1349 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1349&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB SRLR_ECOLI http://www.uniprot.org/uniprot/SRLR_ECOLI UniProtKB-AC P15082 http://www.uniprot.org/uniprot/P15082 charge swissprot:SRLR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SRLR_ECOLI eggNOG COG1349 http://eggnogapi.embl.de/nog_data/html/tree/COG1349 eggNOG ENOG410804X http://eggnogapi.embl.de/nog_data/html/tree/ENOG410804X epestfind swissprot:SRLR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SRLR_ECOLI garnier swissprot:SRLR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SRLR_ECOLI helixturnhelix swissprot:SRLR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SRLR_ECOLI hmoment swissprot:SRLR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SRLR_ECOLI iep swissprot:SRLR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SRLR_ECOLI inforesidue swissprot:SRLR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SRLR_ECOLI octanol swissprot:SRLR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SRLR_ECOLI pepcoil swissprot:SRLR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SRLR_ECOLI pepdigest swissprot:SRLR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SRLR_ECOLI pepinfo swissprot:SRLR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SRLR_ECOLI pepnet swissprot:SRLR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SRLR_ECOLI pepstats swissprot:SRLR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SRLR_ECOLI pepwheel swissprot:SRLR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SRLR_ECOLI pepwindow swissprot:SRLR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SRLR_ECOLI sigcleave swissprot:SRLR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SRLR_ECOLI ## Database ID URL or Descriptions # BioGrid 4259955 2 # COFACTOR Name=L-ascorbate; Xref=ChEBI:CHEBI 38290; Evidence={ECO:0000250}; # COFACTOR YBIX_ECOLI Name=Fe(2+); Xref=ChEBI CHEBI 29033; Evidence={ECO 0000250}; Note=Binds 1 Fe(2+) ion per subunit. {ECO 0000250}; # EcoGene EG13316 ybiX # GO_function GO:0005506 iron ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; IEA:UniProtKB-HAMAP. # GO_function GO:0031418 L-ascorbic acid binding; IEA:UniProtKB-KW. # GO_process GO:0006879 cellular iron ion homeostasis; IEP:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0042592 homeostatic process # HAMAP MF_00657 Hydroxyl_YbiX # InterPro IPR005123 Oxoglu/Fe-dep_dioxygenase # InterPro IPR006620 Pro_4_hyd_alph # InterPro IPR023550 PKHD_hydroxylase # KEGG_Brite ko01000 Enzymes # Organism YBIX_ECOLI Escherichia coli (strain K12) # PATRIC 32116811 VBIEscCol129921_0831 # PIR D64817 D64817 # PROSITE PS51471 FE2OG_OXY # Pfam PF13640 2OG-FeII_Oxy_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBIX_ECOLI PKHD-type hydroxylase YbiX # RefSeq NP_415325 NC_000913.3 # RefSeq WP_000990177 NZ_LN832404.1 # SIMILARITY Contains 1 Fe2OG dioxygenase domain. {ECO 0000305}. # SMART SM00702 P4Hc # eggNOG COG3128 LUCA # eggNOG ENOG4107E2E Bacteria BLAST swissprot:YBIX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBIX_ECOLI BioCyc ECOL316407:JW5105-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5105-MONOMER BioCyc EcoCyc:G6413-MONOMER http://biocyc.org/getid?id=EcoCyc:G6413-MONOMER COG COG3128 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3128 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.14.11.- http://www.genome.jp/dbget-bin/www_bget?EC:1.14.11.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.14.11.- http://enzyme.expasy.org/EC/1.14.11.- EchoBASE EB3100 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3100 EcoGene EG13316 http://www.ecogene.org/geneInfo.php?eg_id=EG13316 EnsemblBacteria AAC73891 http://www.ensemblgenomes.org/id/AAC73891 EnsemblBacteria AAC73891 http://www.ensemblgenomes.org/id/AAC73891 EnsemblBacteria BAA35470 http://www.ensemblgenomes.org/id/BAA35470 EnsemblBacteria BAA35470 http://www.ensemblgenomes.org/id/BAA35470 EnsemblBacteria BAA35470 http://www.ensemblgenomes.org/id/BAA35470 EnsemblBacteria b0804 http://www.ensemblgenomes.org/id/b0804 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0016706 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016706 GO_function GO:0031418 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031418 GO_process GO:0006879 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006879 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GeneID 947502 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947502 HAMAP MF_00657 http://hamap.expasy.org/unirule/MF_00657 HOGENOM HOG000236239 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000236239&db=HOGENOM6 InParanoid P75779 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75779 IntEnz 1.14.11 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.14.11 InterPro IPR005123 http://www.ebi.ac.uk/interpro/entry/IPR005123 InterPro IPR006620 http://www.ebi.ac.uk/interpro/entry/IPR006620 InterPro IPR023550 http://www.ebi.ac.uk/interpro/entry/IPR023550 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5105 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5105 KEGG_Gene eco:b0804 http://www.genome.jp/dbget-bin/www_bget?eco:b0804 KEGG_Orthology KO:K07336 http://www.genome.jp/dbget-bin/www_bget?KO:K07336 OMA DMVLYPG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DMVLYPG PROSITE PS51471 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51471 PSORT swissprot:YBIX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBIX_ECOLI PSORT-B swissprot:YBIX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBIX_ECOLI PSORT2 swissprot:YBIX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBIX_ECOLI Pfam PF13640 http://pfam.xfam.org/family/PF13640 Phobius swissprot:YBIX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBIX_ECOLI PhylomeDB P75779 http://phylomedb.org/?seqid=P75779 ProteinModelPortal P75779 http://www.proteinmodelportal.org/query/uniprot/P75779 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415325 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415325 RefSeq WP_000990177 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000990177 SMART SM00702 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00702 SMR P75779 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75779 STRING 511145.b0804 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0804&targetmode=cogs STRING COG3128 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3128&targetmode=cogs UniProtKB YBIX_ECOLI http://www.uniprot.org/uniprot/YBIX_ECOLI UniProtKB-AC P75779 http://www.uniprot.org/uniprot/P75779 charge swissprot:YBIX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBIX_ECOLI eggNOG COG3128 http://eggnogapi.embl.de/nog_data/html/tree/COG3128 eggNOG ENOG4107E2E http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107E2E epestfind swissprot:YBIX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBIX_ECOLI garnier swissprot:YBIX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBIX_ECOLI helixturnhelix swissprot:YBIX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBIX_ECOLI hmoment swissprot:YBIX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBIX_ECOLI iep swissprot:YBIX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBIX_ECOLI inforesidue swissprot:YBIX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBIX_ECOLI octanol swissprot:YBIX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBIX_ECOLI pepcoil swissprot:YBIX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBIX_ECOLI pepdigest swissprot:YBIX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBIX_ECOLI pepinfo swissprot:YBIX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBIX_ECOLI pepnet swissprot:YBIX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBIX_ECOLI pepstats swissprot:YBIX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBIX_ECOLI pepwheel swissprot:YBIX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBIX_ECOLI pepwindow swissprot:YBIX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBIX_ECOLI sigcleave swissprot:YBIX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBIX_ECOLI ## Database ID URL or Descriptions # BioGrid 4260997 8 # EcoGene EG12903 yheS # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016887 ATPase activity; IEA:InterPro. # GO_process GO:0006810 transport; IEA:UniProtKB-KW. # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # Gene3D 3.40.50.300 -; 2. # INTERACTION YHES_ECOLI P0CE47 tufA; NbExp=2; IntAct=EBI-561198, EBI-301077; # IntAct P63389 11 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # InterPro IPR032781 ABC_tran_Xtn # KEGG_Brite ko03012 Translation factors # Organism YHES_ECOLI Escherichia coli (strain K12) # PATRIC 32122138 VBIEscCol129921_3446 # PIR C65129 C65129 # PROSITE PS00211 ABC_TRANSPORTER_1; 2 # PROSITE PS50893 ABC_TRANSPORTER_2; 2 # Pfam PF00005 ABC_tran; 2 # Pfam PF12848 ABC_tran_Xtn # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHES_ECOLI Uncharacterized ABC transporter ATP-binding protein YheS # RefSeq NP_417811 NC_000913.3 # RefSeq WP_000634798 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily. {ECO 0000305}. # SIMILARITY Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA; 2 # SUPFAM SSF52540 SSF52540; 3 # eggNOG COG0488 LUCA # eggNOG ENOG4105C5H Bacteria BLAST swissprot:YHES_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHES_ECOLI BioCyc ECOL316407:JW3315-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3315-MONOMER BioCyc EcoCyc:YHES-MONOMER http://biocyc.org/getid?id=EcoCyc:YHES-MONOMER COG COG0488 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0488 DIP DIP-48200N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48200N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2740 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2740 EcoGene EG12903 http://www.ecogene.org/geneInfo.php?eg_id=EG12903 EnsemblBacteria AAC76377 http://www.ensemblgenomes.org/id/AAC76377 EnsemblBacteria AAC76377 http://www.ensemblgenomes.org/id/AAC76377 EnsemblBacteria BAE77938 http://www.ensemblgenomes.org/id/BAE77938 EnsemblBacteria BAE77938 http://www.ensemblgenomes.org/id/BAE77938 EnsemblBacteria BAE77938 http://www.ensemblgenomes.org/id/BAE77938 EnsemblBacteria b3352 http://www.ensemblgenomes.org/id/b3352 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947856 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947856 HOGENOM HOG000271640 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000271640&db=HOGENOM6 InParanoid P63389 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P63389 IntAct P63389 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P63389* InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR032781 http://www.ebi.ac.uk/interpro/entry/IPR032781 KEGG_Brite ko03012 http://www.genome.jp/dbget-bin/www_bget?ko03012 KEGG_Gene ecj:JW3315 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3315 KEGG_Gene eco:b3352 http://www.genome.jp/dbget-bin/www_bget?eco:b3352 KEGG_Orthology KO:K06158 http://www.genome.jp/dbget-bin/www_bget?KO:K06158 MINT MINT-1274432 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1274432 OMA FYLVHDK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FYLVHDK PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:YHES_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHES_ECOLI PSORT-B swissprot:YHES_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHES_ECOLI PSORT2 swissprot:YHES_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHES_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Pfam PF12848 http://pfam.xfam.org/family/PF12848 Phobius swissprot:YHES_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHES_ECOLI PhylomeDB P63389 http://phylomedb.org/?seqid=P63389 ProteinModelPortal P63389 http://www.proteinmodelportal.org/query/uniprot/P63389 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417811 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417811 RefSeq WP_000634798 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000634798 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P63389 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P63389 STRING 511145.b3352 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3352&targetmode=cogs STRING COG0488 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0488&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB YHES_ECOLI http://www.uniprot.org/uniprot/YHES_ECOLI UniProtKB-AC P63389 http://www.uniprot.org/uniprot/P63389 charge swissprot:YHES_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHES_ECOLI eggNOG COG0488 http://eggnogapi.embl.de/nog_data/html/tree/COG0488 eggNOG ENOG4105C5H http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C5H epestfind swissprot:YHES_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHES_ECOLI garnier swissprot:YHES_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHES_ECOLI helixturnhelix swissprot:YHES_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHES_ECOLI hmoment swissprot:YHES_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHES_ECOLI iep swissprot:YHES_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHES_ECOLI inforesidue swissprot:YHES_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHES_ECOLI octanol swissprot:YHES_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHES_ECOLI pepcoil swissprot:YHES_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHES_ECOLI pepdigest swissprot:YHES_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHES_ECOLI pepinfo swissprot:YHES_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHES_ECOLI pepnet swissprot:YHES_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHES_ECOLI pepstats swissprot:YHES_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHES_ECOLI pepwheel swissprot:YHES_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHES_ECOLI pepwindow swissprot:YHES_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHES_ECOLI sigcleave swissprot:YHES_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHES_ECOLI ## Database ID URL or Descriptions # AltName LIPA_ECOLI Lip-syn # AltName LIPA_ECOLI Lipoate synthase # AltName LIPA_ECOLI Lipoic acid synthase # AltName LIPA_ECOLI Sulfur insertion protein LipA # BioGrid 4260638 29 # CATALYTIC ACTIVITY Protein N(6)-(octanoyl)lysine + 2 sulfur- (sulfur carrier) + 2 S-adenosyl-L-methionine + 2 reduced [2Fe-2S] ferredoxin = protein N(6)-(lipoyl)lysine + 2 (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine + 2 oxidized [2Fe-2S] ferredoxin. {ECO:0000269|PubMed 15157071}. # COFACTOR LIPA_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000269|PubMed 15362861}; Note=Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L- methionine. {ECO 0000269|PubMed 15362861}; # ENZYME REGULATION LIPA_ECOLI Inhibited by the AdoMet analog S-adenosyl homocysteine. # EcoGene EG11306 lipA # FUNCTION LIPA_ECOLI Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. Free octanoate is not a substrate for LipA. {ECO 0000269|PubMed 11106496, ECO 0000269|PubMed 14700636, ECO 0000269|PubMed 15157071}. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003826 alpha-ketoacid dehydrogenase activity; IMP:CACAO. # GO_function GO:0016992 lipoate synthase activity; IDA:EcoliWiki. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IDA:EcoliWiki. # GO_process GO:0009107 lipoate biosynthetic process; IMP:EcoliWiki. # GO_process GO:0009249 protein lipoylation; IDA:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.20.20.70 -; 1. # HAMAP MF_00206 Lipoyl_synth # IntAct P60716 13 # InterPro IPR003698 Lipoyl_synth # InterPro IPR006638 Elp3/MiaB/NifB # InterPro IPR007197 rSAM # InterPro IPR013785 Aldolase_TIM # InterPro IPR031691 LIAS_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00785 Lipoic acid metabolism # MISCELLANEOUS LIPA_ECOLI The source of sulfurs is the LipA protein itself, most likely one 4Fe-4S cluster. # Organism LIPA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10949 PTHR10949 # PATHWAY Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier- protein]: step 2/2. {ECO 0000269|PubMed:15112987}. # PATRIC 32116437 VBIEscCol129921_0658 # PIR B64797 B64797 # PIRSF PIRSF005963 Lipoyl_synth # Pfam PF04055 Radical_SAM # Pfam PF16881 LIAS_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LIPA_ECOLI Lipoyl synthase # RefSeq NP_415161 NC_000913.3 # RefSeq WP_000042632 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA24072.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the radical SAM superfamily. Lipoyl synthase family. {ECO 0000305}. # SMART SM00729 Elp3 # SUBCELLULAR LOCATION LIPA_ECOLI Cytoplasm. # SUBUNIT LIPA_ECOLI Monomer or homodimer. # TIGRFAMs TIGR00510 lipA # UniPathway UPA00538 UER00593 # eggNOG COG0320 LUCA # eggNOG ENOG4105C0G Bacteria BLAST swissprot:LIPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LIPA_ECOLI BioCyc ECOL316407:JW0623-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0623-MONOMER BioCyc EcoCyc:EG11306-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11306-MONOMER BioCyc MetaCyc:EG11306-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11306-MONOMER COG COG0320 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0320 DIP DIP-48008N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48008N DOI 10.1016/j.chembiol.2003.11.016 http://dx.doi.org/10.1016/j.chembiol.2003.11.016 DOI 10.1016/j.chembiol.2004.01.002 http://dx.doi.org/10.1016/j.chembiol.2004.01.002 DOI 10.1021/bi002060n http://dx.doi.org/10.1021/bi002060n DOI 10.1021/bi0488505 http://dx.doi.org/10.1021/bi0488505 DOI 10.1021/bi049528x http://dx.doi.org/10.1021/bi049528x DOI 10.1021/ja042428u http://dx.doi.org/10.1021/ja042428u DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.8.1.8 {ECO:0000269|PubMed:15157071} http://www.genome.jp/dbget-bin/www_bget?EC:2.8.1.8 {ECO:0000269|PubMed:15157071} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L07636 http://www.ebi.ac.uk/ena/data/view/L07636 EMBL M82805 http://www.ebi.ac.uk/ena/data/view/M82805 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 ENZYME 2.8.1.8 {ECO:0000269|PubMed:15157071} http://enzyme.expasy.org/EC/2.8.1.8 {ECO:0000269|PubMed:15157071} EchoBASE EB1283 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1283 EcoGene EG11306 http://www.ecogene.org/geneInfo.php?eg_id=EG11306 EnsemblBacteria AAC73729 http://www.ensemblgenomes.org/id/AAC73729 EnsemblBacteria AAC73729 http://www.ensemblgenomes.org/id/AAC73729 EnsemblBacteria BAA35271 http://www.ensemblgenomes.org/id/BAA35271 EnsemblBacteria BAA35271 http://www.ensemblgenomes.org/id/BAA35271 EnsemblBacteria BAA35271 http://www.ensemblgenomes.org/id/BAA35271 EnsemblBacteria b0628 http://www.ensemblgenomes.org/id/b0628 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003826 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003826 GO_function GO:0016992 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016992 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0009107 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009107 GO_process GO:0009249 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009249 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 945227 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945227 HAMAP MF_00206 http://hamap.expasy.org/unirule/MF_00206 HOGENOM HOG000235997 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000235997&db=HOGENOM6 InParanoid P60716 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P60716 IntAct P60716 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P60716* IntEnz 2.8.1.8 {ECO:0000269|PubMed:15157071} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.8.1.8 {ECO:0000269|PubMed:15157071} InterPro IPR003698 http://www.ebi.ac.uk/interpro/entry/IPR003698 InterPro IPR006638 http://www.ebi.ac.uk/interpro/entry/IPR006638 InterPro IPR007197 http://www.ebi.ac.uk/interpro/entry/IPR007197 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR031691 http://www.ebi.ac.uk/interpro/entry/IPR031691 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0623 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0623 KEGG_Gene eco:b0628 http://www.genome.jp/dbget-bin/www_bget?eco:b0628 KEGG_Orthology KO:K03644 http://www.genome.jp/dbget-bin/www_bget?KO:K03644 KEGG_Pathway ko00785 http://www.genome.jp/kegg-bin/show_pathway?ko00785 KEGG_Reaction rn:R07767 http://www.genome.jp/dbget-bin/www_bget?rn:R07767 KEGG_Reaction rn:R07768 http://www.genome.jp/dbget-bin/www_bget?rn:R07768 MINT MINT-1310776 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1310776 OMA NVCTRSC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NVCTRSC PANTHER PTHR10949 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10949 PSORT swissprot:LIPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LIPA_ECOLI PSORT-B swissprot:LIPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LIPA_ECOLI PSORT2 swissprot:LIPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LIPA_ECOLI Pfam PF04055 http://pfam.xfam.org/family/PF04055 Pfam PF16881 http://pfam.xfam.org/family/PF16881 Phobius swissprot:LIPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LIPA_ECOLI PhylomeDB P60716 http://phylomedb.org/?seqid=P60716 ProteinModelPortal P60716 http://www.proteinmodelportal.org/query/uniprot/P60716 PubMed 11106496 http://www.ncbi.nlm.nih.gov/pubmed/11106496 PubMed 14700636 http://www.ncbi.nlm.nih.gov/pubmed/14700636 PubMed 15112987 http://www.ncbi.nlm.nih.gov/pubmed/15112987 PubMed 15157071 http://www.ncbi.nlm.nih.gov/pubmed/15157071 PubMed 15362861 http://www.ncbi.nlm.nih.gov/pubmed/15362861 PubMed 15740115 http://www.ncbi.nlm.nih.gov/pubmed/15740115 PubMed 1577793 http://www.ncbi.nlm.nih.gov/pubmed/1577793 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8444795 http://www.ncbi.nlm.nih.gov/pubmed/8444795 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415161 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415161 RefSeq WP_000042632 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000042632 SMART SM00729 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00729 SMR P60716 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P60716 STRING 511145.b0628 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0628&targetmode=cogs STRING COG0320 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0320&targetmode=cogs TIGRFAMs TIGR00510 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00510 UniProtKB LIPA_ECOLI http://www.uniprot.org/uniprot/LIPA_ECOLI UniProtKB-AC P60716 http://www.uniprot.org/uniprot/P60716 charge swissprot:LIPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LIPA_ECOLI eggNOG COG0320 http://eggnogapi.embl.de/nog_data/html/tree/COG0320 eggNOG ENOG4105C0G http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C0G epestfind swissprot:LIPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LIPA_ECOLI garnier swissprot:LIPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LIPA_ECOLI helixturnhelix swissprot:LIPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LIPA_ECOLI hmoment swissprot:LIPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LIPA_ECOLI iep swissprot:LIPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LIPA_ECOLI inforesidue swissprot:LIPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LIPA_ECOLI octanol swissprot:LIPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LIPA_ECOLI pepcoil swissprot:LIPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LIPA_ECOLI pepdigest swissprot:LIPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LIPA_ECOLI pepinfo swissprot:LIPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LIPA_ECOLI pepnet swissprot:LIPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LIPA_ECOLI pepstats swissprot:LIPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LIPA_ECOLI pepwheel swissprot:LIPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LIPA_ECOLI pepwindow swissprot:LIPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LIPA_ECOLI sigcleave swissprot:LIPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LIPA_ECOLI ## Database ID URL or Descriptions # AltName GLF_ECOLI UDP-GALP mutase # AltName GLF_ECOLI Uridine 5-diphosphate galactopyranose mutase # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=194 uM for UDP-GalF {ECO 0000269|PubMed:11448178}; Note=Kcat is 1.5 (sec-1) for UDP-GalF.; # BRENDA 5.4.99 2026 # BioGrid 4260648 99 # CATALYTIC ACTIVITY UDP-alpha-D-galactopyranose = UDP-alpha-D- galactofuranose. {ECO:0000269|PubMed 8576037}. # COFACTOR GLF_ECOLI Name=FAD; Xref=ChEBI CHEBI 57692; Evidence={ECO 0000269|PubMed 8576037}; Note=Binds 1 FAD per subunit. {ECO 0000269|PubMed 8576037}; # DrugBank DB03147 Flavin adenine dinucleotide # EcoGene EG11981 glf # FUNCTION GLF_ECOLI Catalyzes the interconversion through a 2-keto intermediate of uridine diphosphogalactopyranose (UDP-GalP) into uridine diphosphogalactofuranose (UDP-GalF). {ECO 0000250, ECO 0000269|PubMed 11448178, ECO 0000269|PubMed 8576037}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008767 UDP-galactopyranose mutase activity; IDA:EcoCyc. # GO_function GO:0050660 flavin adenine dinucleotide binding; IDA:EcoCyc. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.720 -; 3. # IntAct P37747 4 # InterPro IPR004379 UDP-GALP_mutase # InterPro IPR015899 UDP-GalPyranose_mutase_C # InterPro IPR016040 NAD(P)-bd_dom # KEGG_Brite ko01000 Enzymes # MASS SPECTROMETRY Mass=42960; Mass_error=8; Method=Electrospray; Range=1-367; Evidence={ECO:0000269|PubMed 8576037}; # Organism GLF_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21197 PTHR21197 # PATHWAY GLF_ECOLI Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. # PATRIC 32119405 VBIEscCol129921_2112 # PDB 1I8T X-ray; 2.40 A; A/B=1-367 # PIR I69653 I69653 # Pfam PF03275 GLF # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLF_ECOLI UDP-galactopyranose mutase # RefSeq NP_416540 NC_000913.3 # RefSeq WP_000272486 NZ_LN832404.1 # SIMILARITY Belongs to the UDP-galactopyranose/dTDP-fucopyranose mutase family. {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 11573090}. # TIGRFAMs TIGR00031 UDP-GALP_mutase # eggNOG COG0562 LUCA # eggNOG ENOG4105D5D Bacteria BLAST swissprot:GLF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLF_ECOLI BioCyc ECOL316407:JW2021-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2021-MONOMER BioCyc EcoCyc:GALPMUT-MONOMER http://biocyc.org/getid?id=EcoCyc:GALPMUT-MONOMER BioCyc MetaCyc:GALPMUT-MONOMER http://biocyc.org/getid?id=MetaCyc:GALPMUT-MONOMER COG COG0562 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0562 DIP DIP-6863N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-6863N DOI 10.1021/ja010473l http://dx.doi.org/10.1021/ja010473l DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb1001-858 http://dx.doi.org/10.1038/nsb1001-858 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB03147 http://www.drugbank.ca/drugs/DB03147 EC_number EC:5.4.99.9 http://www.genome.jp/dbget-bin/www_bget?EC:5.4.99.9 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U03041 http://www.ebi.ac.uk/ena/data/view/U03041 EMBL U09876 http://www.ebi.ac.uk/ena/data/view/U09876 ENZYME 5.4.99.9 http://enzyme.expasy.org/EC/5.4.99.9 EchoBASE EB1924 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1924 EcoGene EG11981 http://www.ecogene.org/geneInfo.php?eg_id=EG11981 EnsemblBacteria AAC75097 http://www.ensemblgenomes.org/id/AAC75097 EnsemblBacteria AAC75097 http://www.ensemblgenomes.org/id/AAC75097 EnsemblBacteria BAA15878 http://www.ensemblgenomes.org/id/BAA15878 EnsemblBacteria BAA15878 http://www.ensemblgenomes.org/id/BAA15878 EnsemblBacteria BAA15878 http://www.ensemblgenomes.org/id/BAA15878 EnsemblBacteria b2036 http://www.ensemblgenomes.org/id/b2036 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008767 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008767 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 945235 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945235 HOGENOM HOG000247596 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000247596&db=HOGENOM6 InParanoid P37747 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37747 IntAct P37747 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37747* IntEnz 5.4.99.9 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.4.99.9 InterPro IPR004379 http://www.ebi.ac.uk/interpro/entry/IPR004379 InterPro IPR015899 http://www.ebi.ac.uk/interpro/entry/IPR015899 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2021 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2021 KEGG_Gene eco:b2036 http://www.genome.jp/dbget-bin/www_bget?eco:b2036 KEGG_Orthology KO:K01854 http://www.genome.jp/dbget-bin/www_bget?KO:K01854 MINT MINT-1308638 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1308638 OMA GKQWQTD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GKQWQTD PANTHER PTHR21197 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21197 PDB 1I8T http://www.ebi.ac.uk/pdbe-srv/view/entry/1I8T PDBsum 1I8T http://www.ebi.ac.uk/pdbsum/1I8T PSORT swissprot:GLF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLF_ECOLI PSORT-B swissprot:GLF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLF_ECOLI PSORT2 swissprot:GLF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLF_ECOLI Pfam PF03275 http://pfam.xfam.org/family/PF03275 Phobius swissprot:GLF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLF_ECOLI PhylomeDB P37747 http://phylomedb.org/?seqid=P37747 ProteinModelPortal P37747 http://www.proteinmodelportal.org/query/uniprot/P37747 PubMed 11448178 http://www.ncbi.nlm.nih.gov/pubmed/11448178 PubMed 11573090 http://www.ncbi.nlm.nih.gov/pubmed/11573090 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7517390 http://www.ncbi.nlm.nih.gov/pubmed/7517390 PubMed 7517391 http://www.ncbi.nlm.nih.gov/pubmed/7517391 PubMed 8576037 http://www.ncbi.nlm.nih.gov/pubmed/8576037 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416540 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416540 RefSeq WP_000272486 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000272486 SMR P37747 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37747 STRING 511145.b2036 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2036&targetmode=cogs STRING COG0562 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0562&targetmode=cogs TIGRFAMs TIGR00031 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00031 UniProtKB GLF_ECOLI http://www.uniprot.org/uniprot/GLF_ECOLI UniProtKB-AC P37747 http://www.uniprot.org/uniprot/P37747 charge swissprot:GLF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLF_ECOLI eggNOG COG0562 http://eggnogapi.embl.de/nog_data/html/tree/COG0562 eggNOG ENOG4105D5D http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D5D epestfind swissprot:GLF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLF_ECOLI garnier swissprot:GLF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLF_ECOLI helixturnhelix swissprot:GLF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLF_ECOLI hmoment swissprot:GLF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLF_ECOLI iep swissprot:GLF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLF_ECOLI inforesidue swissprot:GLF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLF_ECOLI octanol swissprot:GLF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLF_ECOLI pepcoil swissprot:GLF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLF_ECOLI pepdigest swissprot:GLF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLF_ECOLI pepinfo swissprot:GLF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLF_ECOLI pepnet swissprot:GLF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLF_ECOLI pepstats swissprot:GLF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLF_ECOLI pepwheel swissprot:GLF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLF_ECOLI pepwindow swissprot:GLF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLF_ECOLI sigcleave swissprot:GLF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLF_ECOLI ## Database ID URL or Descriptions # BioGrid 4260431 8 # EcoGene EG12418 gatZ # FUNCTION GATZ_ECOLI Component of the tagatose-1,6-bisphosphate aldolase GatYZ that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of GatY. When expressed alone, GatZ does not show any aldolase activity. Is involved in the catabolism of galactitol. {ECO 0000269|PubMed 11976750, ECO 0000269|PubMed 8955298}. # GO_function GO:0003824 catalytic activity; IEA:InterPro. # GO_process GO:0019404 galactitol catabolic process; IEA:UniProtKB-HAMAP. # GO_process GO:2001059 D-tagatose 6-phosphate catabolic process; IEA:UniProtKB-UniPathway. # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.70 -; 1. # HAMAP MF_01296 Tagatose_aldol_GatZ # INDUCTION Constitutively expressed. {ECO:0000269|PubMed 8955298}. # IntAct P0C8J8 17 # InterPro IPR012062 TagBP_ald_GatZ/KbaZ # InterPro IPR013785 Aldolase_TIM # InterPro IPR023436 TagBP_ald_GatZ # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko00052 Galactose metabolism # Organism GATZ_ECOLI Escherichia coli (strain K12) # PATHWAY Carbohydrate metabolism; D-tagatose 6-phosphate degradation; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate step 2/2. # PATRIC 32119523 VBIEscCol129921_2172 # PIR F64976 F64976 # PIR S55902 S55902 # PIRSF PIRSF009264 TagBP_ald_AgaZ # Pfam PF08013 Tagatose_6_P_K # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GATZ_ECOLI D-tagatose-1,6-bisphosphate aldolase subunit GatZ # RefSeq NP_416598 NC_000913.3 # RefSeq WP_000853883 NZ_LN832404.1 # SIMILARITY Belongs to the GatZ/KbaZ family. GatZ subfamily. {ECO 0000305}. # SUBUNIT GATZ_ECOLI Forms a complex with GatY. # TIGRFAMs TIGR02810 agaZ_gatZ # UniPathway UPA00704 UER00716 # eggNOG COG4573 LUCA # eggNOG ENOG4105C6Q Bacteria BLAST swissprot:GATZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GATZ_ECOLI BioCyc EcoCyc:G7128-MONOMER http://biocyc.org/getid?id=EcoCyc:G7128-MONOMER BioCyc MetaCyc:G7128-MONOMER http://biocyc.org/getid?id=MetaCyc:G7128-MONOMER COG COG4573 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4573 DIP DIP-48243N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48243N DOI 10.1007/s00203-002-0406-6 http://dx.doi.org/10.1007/s00203-002-0406-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1266/ggs.82.291 http://dx.doi.org/10.1266/ggs.82.291 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2317 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2317 EcoGene EG12418 http://www.ecogene.org/geneInfo.php?eg_id=EG12418 EnsemblBacteria AAC75156 http://www.ensemblgenomes.org/id/AAC75156 EnsemblBacteria AAC75156 http://www.ensemblgenomes.org/id/AAC75156 EnsemblBacteria BAA15965 http://www.ensemblgenomes.org/id/BAA15965 EnsemblBacteria BAA15965 http://www.ensemblgenomes.org/id/BAA15965 EnsemblBacteria BAA15965 http://www.ensemblgenomes.org/id/BAA15965 EnsemblBacteria b2095 http://www.ensemblgenomes.org/id/b2095 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003824 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003824 GO_process GO:0019404 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019404 GO_process GO:2001059 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2001059 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 946641 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946641 HAMAP MF_01296 http://hamap.expasy.org/unirule/MF_01296 HOGENOM HOG000263918 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000263918&db=HOGENOM6 InParanoid P0C8J8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0C8J8 IntAct P0C8J8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0C8J8* InterPro IPR012062 http://www.ebi.ac.uk/interpro/entry/IPR012062 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR023436 http://www.ebi.ac.uk/interpro/entry/IPR023436 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW2082 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2082 KEGG_Gene eco:b2095 http://www.genome.jp/dbget-bin/www_bget?eco:b2095 KEGG_Orthology KO:K16371 http://www.genome.jp/dbget-bin/www_bget?KO:K16371 KEGG_Pathway ko00052 http://www.genome.jp/kegg-bin/show_pathway?ko00052 KEGG_Reaction rn:R01069 http://www.genome.jp/dbget-bin/www_bget?rn:R01069 OMA EQIGICS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EQIGICS PSORT swissprot:GATZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GATZ_ECOLI PSORT-B swissprot:GATZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GATZ_ECOLI PSORT2 swissprot:GATZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GATZ_ECOLI Pfam PF08013 http://pfam.xfam.org/family/PF08013 Phobius swissprot:GATZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GATZ_ECOLI PhylomeDB P0C8J8 http://phylomedb.org/?seqid=P0C8J8 ProteinModelPortal P0C8J8 http://www.proteinmodelportal.org/query/uniprot/P0C8J8 PubMed 11976750 http://www.ncbi.nlm.nih.gov/pubmed/11976750 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17895580 http://www.ncbi.nlm.nih.gov/pubmed/17895580 PubMed 8955298 http://www.ncbi.nlm.nih.gov/pubmed/8955298 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416598 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416598 RefSeq WP_000853883 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000853883 SMR P0C8J8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0C8J8 STRING 511145.b2095 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2095&targetmode=cogs STRING COG4573 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4573&targetmode=cogs TIGRFAMs TIGR02810 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02810 UniProtKB GATZ_ECOLI http://www.uniprot.org/uniprot/GATZ_ECOLI UniProtKB-AC P0C8J8 http://www.uniprot.org/uniprot/P0C8J8 charge swissprot:GATZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GATZ_ECOLI eggNOG COG4573 http://eggnogapi.embl.de/nog_data/html/tree/COG4573 eggNOG ENOG4105C6Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C6Q epestfind swissprot:GATZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GATZ_ECOLI garnier swissprot:GATZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GATZ_ECOLI helixturnhelix swissprot:GATZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GATZ_ECOLI hmoment swissprot:GATZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GATZ_ECOLI iep swissprot:GATZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GATZ_ECOLI inforesidue swissprot:GATZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GATZ_ECOLI octanol swissprot:GATZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GATZ_ECOLI pepcoil swissprot:GATZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GATZ_ECOLI pepdigest swissprot:GATZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GATZ_ECOLI pepinfo swissprot:GATZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GATZ_ECOLI pepnet swissprot:GATZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GATZ_ECOLI pepstats swissprot:GATZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GATZ_ECOLI pepwheel swissprot:GATZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GATZ_ECOLI pepwindow swissprot:GATZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GATZ_ECOLI sigcleave swissprot:GATZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GATZ_ECOLI ## Database ID URL or Descriptions # BioGrid 4261872 25 # EcoGene EG12518 ytfR # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0015407 monosaccharide-transporting ATPase activity; IDA:EcoCyc. # GO_process GO:0015757 galactose transport; IDA:EcoCyc. # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # Gene3D 3.40.50.300 -; 2. # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00221 Putative simple sugar transport system # KEGG_Brite ko02000 Transporters # Organism YTFR_ECOLI Escherichia coli (strain K12) # PATRIC 32124031 VBIEscCol129921_4360 # PIR S56454 S56454 # PIR S56455 S56455 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2; 2 # Pfam PF00005 ABC_tran; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YTFR_ECOLI Uncharacterized ABC transporter ATP-binding protein YtfR # RefSeq WP_000205805 NZ_LN832404.1 # RefSeq YP_026286 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA97126.1; Type=Frameshift; Positions=369; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ABC transporter superfamily. {ECO 0000305}. # SIMILARITY Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA; 2 # SUPFAM SSF52540 SSF52540; 2 # TCDB 3.A.1.2.25 the atp-binding cassette (abc) superfamily # eggNOG COG1129 LUCA # eggNOG ENOG4105C2J Bacteria BLAST swissprot:YTFR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YTFR_ECOLI BioCyc ECOL316407:JW5752-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5752-MONOMER BioCyc EcoCyc:YTFR-MONOMER http://biocyc.org/getid?id=EcoCyc:YTFR-MONOMER BioCyc MetaCyc:YTFR-MONOMER http://biocyc.org/getid?id=MetaCyc:YTFR-MONOMER COG COG1129 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1129 COG COG3845 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3845 DIP DIP-48183N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48183N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2410 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2410 EcoGene EG12518 http://www.ecogene.org/geneInfo.php?eg_id=EG12518 EnsemblBacteria AAT48244 http://www.ensemblgenomes.org/id/AAT48244 EnsemblBacteria AAT48244 http://www.ensemblgenomes.org/id/AAT48244 EnsemblBacteria BAE78229 http://www.ensemblgenomes.org/id/BAE78229 EnsemblBacteria BAE78229 http://www.ensemblgenomes.org/id/BAE78229 EnsemblBacteria BAE78229 http://www.ensemblgenomes.org/id/BAE78229 EnsemblBacteria b4485 http://www.ensemblgenomes.org/id/b4485 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0015407 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015407 GO_process GO:0015757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015757 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 2847725 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2847725 InParanoid Q6BEX0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q6BEX0 InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5752 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5752 KEGG_Gene eco:b4485 http://www.genome.jp/dbget-bin/www_bget?eco:b4485 KEGG_Orthology KO:K02056 http://www.genome.jp/dbget-bin/www_bget?KO:K02056 OMA ESNALQR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ESNALQR PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:YTFR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YTFR_ECOLI PSORT-B swissprot:YTFR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YTFR_ECOLI PSORT2 swissprot:YTFR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YTFR_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Phobius swissprot:YTFR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YTFR_ECOLI PhylomeDB Q6BEX0 http://phylomedb.org/?seqid=Q6BEX0 ProteinModelPortal Q6BEX0 http://www.proteinmodelportal.org/query/uniprot/Q6BEX0 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000205805 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000205805 RefSeq YP_026286 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026286 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 STRING 511145.b4485 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4485&targetmode=cogs STRING COG1129 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1129&targetmode=cogs STRING COG3845 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3845&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.2.25 http://www.tcdb.org/search/result.php?tc=3.A.1.2.25 UniProtKB YTFR_ECOLI http://www.uniprot.org/uniprot/YTFR_ECOLI UniProtKB-AC Q6BEX0 http://www.uniprot.org/uniprot/Q6BEX0 charge swissprot:YTFR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YTFR_ECOLI eggNOG COG1129 http://eggnogapi.embl.de/nog_data/html/tree/COG1129 eggNOG ENOG4105C2J http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C2J epestfind swissprot:YTFR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YTFR_ECOLI garnier swissprot:YTFR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YTFR_ECOLI helixturnhelix swissprot:YTFR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YTFR_ECOLI hmoment swissprot:YTFR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YTFR_ECOLI iep swissprot:YTFR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YTFR_ECOLI inforesidue swissprot:YTFR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YTFR_ECOLI octanol swissprot:YTFR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YTFR_ECOLI pepcoil swissprot:YTFR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YTFR_ECOLI pepdigest swissprot:YTFR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YTFR_ECOLI pepinfo swissprot:YTFR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YTFR_ECOLI pepnet swissprot:YTFR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YTFR_ECOLI pepstats swissprot:YTFR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YTFR_ECOLI pepwheel swissprot:YTFR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YTFR_ECOLI pepwindow swissprot:YTFR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YTFR_ECOLI sigcleave swissprot:YTFR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YTFR_ECOLI ## Database ID URL or Descriptions # AltName GSPD_ECOLI Putative general secretion pathway protein D # BioGrid 4261297 268 # EcoGene EG12890 gspD # FUNCTION GSPD_ECOLI Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. {ECO 0000305}. # GO_component GO:0009279 cell outer membrane; IEA:UniProtKB-SubCell. # GO_component GO:0015627 type II protein secretion system complex; IEA:InterPro. # GO_function GO:0008565 protein transporter activity; IEA:InterPro. # GO_process GO:0015628 protein secretion by the type II secretion system; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043234 protein complex # GOslim_function GO:0008565 protein transporter activity # GOslim_process GO:0055085 transmembrane transport # INDUCTION Silenced by the DNA-binding protein H-NS under standard growth conditions. {ECO:0000269|PubMed 11118204}. # InterPro IPR001775 GspD/PilQ # InterPro IPR004845 T2SS_GspD_CS # InterPro IPR004846 T2SS/T3SS # InterPro IPR005644 NolW-like # InterPro IPR013356 T2SS_GspD # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02044 M00331 Type II general secretion system # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko03070 Bacterial secretion system # MISCELLANEOUS GSPD_ECOLI Part of a cryptic operon that encodes proteins involved in type II secretion machinery in other organisms, but is not expressed in strain K12. # Organism GSPD_ECOLI Escherichia coli (strain K12) # PATRIC 32122082 VBIEscCol129921_3418 # PIR H65125 H65125 # PRINTS PR00811 BCTERIALGSPD # PROSITE PS00875 T2SP_D # Pfam PF00263 Secretin # Pfam PF03958 Secretin_N; 3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GSPD_ECOLI Putative type II secretion system protein D # RefSeq NP_417784 NC_000913.3 # RefSeq WP_001326512 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA58122.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the GSP D family. {ECO 0000305}. # SUBCELLULAR LOCATION GSPD_ECOLI Cell outer membrane {ECO 0000305}. # TIGRFAMs TIGR02517 type_II_gspD # eggNOG COG1450 LUCA # eggNOG ENOG4105GVR Bacteria BLAST swissprot:GSPD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GSPD_ECOLI BioCyc ECOL316407:JW5707-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5707-MONOMER BioCyc EcoCyc:G7703-MONOMER http://biocyc.org/getid?id=EcoCyc:G7703-MONOMER BioCyc MetaCyc:G7703-MONOMER http://biocyc.org/getid?id=MetaCyc:G7703-MONOMER COG COG1450 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1450 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/emboj/19.24.6697 http://dx.doi.org/10.1093/emboj/19.24.6697 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2727 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2727 EcoGene EG12890 http://www.ecogene.org/geneInfo.php?eg_id=EG12890 EnsemblBacteria AAC76350 http://www.ensemblgenomes.org/id/AAC76350 EnsemblBacteria AAC76350 http://www.ensemblgenomes.org/id/AAC76350 EnsemblBacteria BAE77966 http://www.ensemblgenomes.org/id/BAE77966 EnsemblBacteria BAE77966 http://www.ensemblgenomes.org/id/BAE77966 EnsemblBacteria BAE77966 http://www.ensemblgenomes.org/id/BAE77966 EnsemblBacteria b3325 http://www.ensemblgenomes.org/id/b3325 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0015627 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015627 GO_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GO_process GO:0015628 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015628 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 947822 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947822 HOGENOM HOG000253751 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000253751&db=HOGENOM6 InParanoid P45758 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45758 InterPro IPR001775 http://www.ebi.ac.uk/interpro/entry/IPR001775 InterPro IPR004845 http://www.ebi.ac.uk/interpro/entry/IPR004845 InterPro IPR004846 http://www.ebi.ac.uk/interpro/entry/IPR004846 InterPro IPR005644 http://www.ebi.ac.uk/interpro/entry/IPR005644 InterPro IPR013356 http://www.ebi.ac.uk/interpro/entry/IPR013356 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW5707 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5707 KEGG_Gene eco:b3325 http://www.genome.jp/dbget-bin/www_bget?eco:b3325 KEGG_Orthology KO:K02453 http://www.genome.jp/dbget-bin/www_bget?KO:K02453 KEGG_Pathway ko03070 http://www.genome.jp/kegg-bin/show_pathway?ko03070 OMA QQAVQGN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QQAVQGN PRINTS PR00811 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00811 PROSITE PS00875 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00875 PSORT swissprot:GSPD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GSPD_ECOLI PSORT-B swissprot:GSPD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GSPD_ECOLI PSORT2 swissprot:GSPD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GSPD_ECOLI Pfam PF00263 http://pfam.xfam.org/family/PF00263 Pfam PF03958 http://pfam.xfam.org/family/PF03958 Phobius swissprot:GSPD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GSPD_ECOLI PhylomeDB P45758 http://phylomedb.org/?seqid=P45758 ProteinModelPortal P45758 http://www.proteinmodelportal.org/query/uniprot/P45758 PubMed 11118204 http://www.ncbi.nlm.nih.gov/pubmed/11118204 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8655552 http://www.ncbi.nlm.nih.gov/pubmed/8655552 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417784 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417784 RefSeq WP_001326512 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001326512 SMR P45758 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45758 STRING 511145.b3325 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3325&targetmode=cogs STRING COG1450 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1450&targetmode=cogs TIGRFAMs TIGR02517 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02517 UniProtKB GSPD_ECOLI http://www.uniprot.org/uniprot/GSPD_ECOLI UniProtKB-AC P45758 http://www.uniprot.org/uniprot/P45758 charge swissprot:GSPD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GSPD_ECOLI eggNOG COG1450 http://eggnogapi.embl.de/nog_data/html/tree/COG1450 eggNOG ENOG4105GVR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105GVR epestfind swissprot:GSPD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GSPD_ECOLI garnier swissprot:GSPD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GSPD_ECOLI helixturnhelix swissprot:GSPD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GSPD_ECOLI hmoment swissprot:GSPD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GSPD_ECOLI iep swissprot:GSPD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GSPD_ECOLI inforesidue swissprot:GSPD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GSPD_ECOLI octanol swissprot:GSPD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GSPD_ECOLI pepcoil swissprot:GSPD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GSPD_ECOLI pepdigest swissprot:GSPD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GSPD_ECOLI pepinfo swissprot:GSPD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GSPD_ECOLI pepnet swissprot:GSPD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GSPD_ECOLI pepstats swissprot:GSPD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GSPD_ECOLI pepwheel swissprot:GSPD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GSPD_ECOLI pepwindow swissprot:GSPD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GSPD_ECOLI sigcleave swissprot:GSPD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GSPD_ECOLI ## Database ID URL or Descriptions # AltName DEOB_ECOLI Phosphodeoxyribomutase # BRENDA 5.4.2 2026 # BioGrid 4263160 8 # CATALYTIC ACTIVITY DEOB_ECOLI 2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy- alpha-D-ribose 5-phosphate. # CATALYTIC ACTIVITY DEOB_ECOLI Alpha-D-ribose 1-phosphate = D-ribose 5- phosphate. # COFACTOR DEOB_ECOLI Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000305}; Note=Binds 1 or 2 manganese ions. {ECO 0000305}; # EcoGene EG10220 deoB # FUNCTION DEOB_ECOLI Phosphotransfer between the C1 and C5 carbon atoms of pentose. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IEA:InterPro. # GO_function GO:0008973 phosphopentomutase activity; IDA:EcoCyc. # GO_function GO:0030145 manganese ion binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0009264 deoxyribonucleotide catabolic process; IEA:UniProtKB-HAMAP. # GO_process GO:0043094 cellular metabolic compound salvage; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.30.70.1250 -; 1. # Gene3D 3.40.720.10 -; 2. # HAMAP MF_00740 Phosphopentomut # IntAct P0A6K6 6 # InterPro IPR006124 Metalloenzyme # InterPro IPR010045 DeoB # InterPro IPR017849 Alkaline_Pase-like_a/b/a # InterPro IPR017850 Alkaline_phosphatase_core # InterPro IPR024052 Phosphopentomutase_DeoB_cap # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00030 Pentose phosphate pathway # KEGG_Pathway ko00230 Purine metabolism # Organism DEOB_ECOLI Escherichia coli (strain K12) # PATHWAY Metabolic intermediate biosynthesis; 5-phospho-alpha-D- ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1- diphosphate from D-ribose 5-phosphate (route II) step 1/3. # PATRIC 32124382 VBIEscCol129921_4531 # PIR S56607 S56607 # PIRSF PIRSF001491 Ppentomutase # Pfam PF01676 Metalloenzyme # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DEOB_ECOLI Phosphopentomutase # RefSeq NP_418800 NC_000913.3 # RefSeq WP_000816471 NZ_LN832404.1 # SIMILARITY Belongs to the phosphopentomutase family. {ECO 0000305}. # SUBCELLULAR LOCATION DEOB_ECOLI Cytoplasm. # SUPFAM SSF143856 SSF143856 # SUPFAM SSF53649 SSF53649; 2 # TIGRFAMs TIGR01696 deoB # UniPathway UPA00087 UER00173 # eggNOG COG1015 LUCA # eggNOG ENOG4105CZG Bacteria BLAST swissprot:DEOB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DEOB_ECOLI BioCyc ECOL316407:JW4346-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4346-MONOMER BioCyc EcoCyc:PPENTOMUT-MONOMER http://biocyc.org/getid?id=EcoCyc:PPENTOMUT-MONOMER BioCyc MetaCyc:PPENTOMUT-MONOMER http://biocyc.org/getid?id=MetaCyc:PPENTOMUT-MONOMER COG COG1015 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1015 DIP DIP-48057N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48057N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/nar/12.13.5211 http://dx.doi.org/10.1093/nar/12.13.5211 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.4.2.7 http://www.genome.jp/dbget-bin/www_bget?EC:5.4.2.7 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X00742 http://www.ebi.ac.uk/ena/data/view/X00742 ENZYME 5.4.2.7 http://enzyme.expasy.org/EC/5.4.2.7 EchoBASE EB0216 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0216 EcoGene EG10220 http://www.ecogene.org/geneInfo.php?eg_id=EG10220 EnsemblBacteria AAC77336 http://www.ensemblgenomes.org/id/AAC77336 EnsemblBacteria AAC77336 http://www.ensemblgenomes.org/id/AAC77336 EnsemblBacteria BAE78372 http://www.ensemblgenomes.org/id/BAE78372 EnsemblBacteria BAE78372 http://www.ensemblgenomes.org/id/BAE78372 EnsemblBacteria BAE78372 http://www.ensemblgenomes.org/id/BAE78372 EnsemblBacteria b4383 http://www.ensemblgenomes.org/id/b4383 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0008973 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008973 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_process GO:0006015 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006015 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0009264 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009264 GO_process GO:0043094 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043094 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.30.70.1250 http://www.cathdb.info/version/latest/superfamily/3.30.70.1250 Gene3D 3.40.720.10 http://www.cathdb.info/version/latest/superfamily/3.40.720.10 GeneID 948910 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948910 HAMAP MF_00740 http://hamap.expasy.org/unirule/MF_00740 HOGENOM HOG000008159 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000008159&db=HOGENOM6 InParanoid P0A6K6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6K6 IntAct P0A6K6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6K6* IntEnz 5.4.2.7 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.4.2.7 InterPro IPR006124 http://www.ebi.ac.uk/interpro/entry/IPR006124 InterPro IPR010045 http://www.ebi.ac.uk/interpro/entry/IPR010045 InterPro IPR017849 http://www.ebi.ac.uk/interpro/entry/IPR017849 InterPro IPR017850 http://www.ebi.ac.uk/interpro/entry/IPR017850 InterPro IPR024052 http://www.ebi.ac.uk/interpro/entry/IPR024052 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4346 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4346 KEGG_Gene eco:b4383 http://www.genome.jp/dbget-bin/www_bget?eco:b4383 KEGG_Orthology KO:K01839 http://www.genome.jp/dbget-bin/www_bget?KO:K01839 KEGG_Pathway ko00030 http://www.genome.jp/kegg-bin/show_pathway?ko00030 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Reaction rn:R01057 http://www.genome.jp/dbget-bin/www_bget?rn:R01057 KEGG_Reaction rn:R02749 http://www.genome.jp/dbget-bin/www_bget?rn:R02749 OMA YLGNCHA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YLGNCHA PSORT swissprot:DEOB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DEOB_ECOLI PSORT-B swissprot:DEOB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DEOB_ECOLI PSORT2 swissprot:DEOB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DEOB_ECOLI Pfam PF01676 http://pfam.xfam.org/family/PF01676 Phobius swissprot:DEOB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DEOB_ECOLI PhylomeDB P0A6K6 http://phylomedb.org/?seqid=P0A6K6 ProteinModelPortal P0A6K6 http://www.proteinmodelportal.org/query/uniprot/P0A6K6 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 6087276 http://www.ncbi.nlm.nih.gov/pubmed/6087276 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418800 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418800 RefSeq WP_000816471 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000816471 SMR P0A6K6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6K6 STRING 511145.b4383 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4383&targetmode=cogs STRING COG1015 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1015&targetmode=cogs SUPFAM SSF143856 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF143856 SUPFAM SSF53649 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53649 TIGRFAMs TIGR01696 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01696 UniProtKB DEOB_ECOLI http://www.uniprot.org/uniprot/DEOB_ECOLI UniProtKB-AC P0A6K6 http://www.uniprot.org/uniprot/P0A6K6 charge swissprot:DEOB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DEOB_ECOLI eggNOG COG1015 http://eggnogapi.embl.de/nog_data/html/tree/COG1015 eggNOG ENOG4105CZG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CZG epestfind swissprot:DEOB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DEOB_ECOLI garnier swissprot:DEOB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DEOB_ECOLI helixturnhelix swissprot:DEOB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DEOB_ECOLI hmoment swissprot:DEOB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DEOB_ECOLI iep swissprot:DEOB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DEOB_ECOLI inforesidue swissprot:DEOB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DEOB_ECOLI octanol swissprot:DEOB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DEOB_ECOLI pepcoil swissprot:DEOB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DEOB_ECOLI pepdigest swissprot:DEOB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DEOB_ECOLI pepinfo swissprot:DEOB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DEOB_ECOLI pepnet swissprot:DEOB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DEOB_ECOLI pepstats swissprot:DEOB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DEOB_ECOLI pepwheel swissprot:DEOB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DEOB_ECOLI pepwindow swissprot:DEOB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DEOB_ECOLI sigcleave swissprot:DEOB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DEOB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260144 11 # BioGrid 4260145 9 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG13919 ycjV # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IEA:InterPro. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances; IEA:InterPro. # GO_function GO:0016887 ATPase activity; IEA:InterPro. # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.300 -; 1. # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR008995 Mo/tungstate-bd_C_term_dom # InterPro IPR013611 Transp-assoc_OB_typ2 # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # Organism YCJV_ECOLI Escherichia coli (strain K12) # PATRIC 48661931 VBIEscCol107702_1329 # PIR A64881 A64881 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # Pfam PF00005 ABC_tran # Pfam PF08402 TOBE_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCJV_ECOLI Putative uncharacterized ABC transporter ATP-binding protein YcjV # SEQUENCE CAUTION YCJV_ECOLI Sequence=AAC34719.1; Type=Frameshift; Positions=321; Evidence={ECO 0000305}; Sequence=BAA14893.1; Type=Frameshift; Positions=321; Evidence={ECO 0000305}; Sequence=BAE76400.1; Type=Frameshift; Positions=321; Evidence={ECO 0000305}; Sequence=U00096; Type=Frameshift; Positions=321; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ABC transporter superfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA # SUPFAM SSF50331 SSF50331 # SUPFAM SSF52540 SSF52540 # TCDB 3.A.1.1.46 the atp-binding cassette (abc) superfamily # eggNOG COG3839 LUCA # eggNOG ENOG4108IJ9 Bacteria BLAST swissprot:YCJV_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCJV_ECOLI BioCyc ECOL316407:JW1311-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1311-MONOMER BioCyc ECOL316407:JW5203-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5203-MONOMER BioCyc EcoCyc:MONOMER0-2667 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2667 BioCyc EcoCyc:YCJV-MONOMER http://biocyc.org/getid?id=EcoCyc:YCJV-MONOMER DIP DIP-11613N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11613N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U49400 http://www.ebi.ac.uk/ena/data/view/U49400 EchoBASE EB3678 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3678 EcoGene EG13919 http://www.ecogene.org/geneInfo.php?eg_id=EG13919 EnsemblBacteria BAA14893 http://www.ensemblgenomes.org/id/BAA14893 EnsemblBacteria BAA14893 http://www.ensemblgenomes.org/id/BAA14893 EnsemblBacteria BAA14893 http://www.ensemblgenomes.org/id/BAA14893 EnsemblBacteria BAE76400 http://www.ensemblgenomes.org/id/BAE76400 EnsemblBacteria BAE76400 http://www.ensemblgenomes.org/id/BAE76400 EnsemblBacteria BAE76400 http://www.ensemblgenomes.org/id/BAE76400 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016820 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016820 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 InParanoid P77481 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77481 InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR008995 http://www.ebi.ac.uk/interpro/entry/IPR008995 InterPro IPR013611 http://www.ebi.ac.uk/interpro/entry/IPR013611 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Gene ecj:JW1311 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1311 KEGG_Gene ecj:JW5203 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5203 OMA ATHYSVE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ATHYSVE PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:YCJV_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCJV_ECOLI PSORT-B swissprot:YCJV_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCJV_ECOLI PSORT2 swissprot:YCJV_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCJV_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Pfam PF08402 http://pfam.xfam.org/family/PF08402 Phobius swissprot:YCJV_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCJV_ECOLI PhylomeDB P77481 http://phylomedb.org/?seqid=P77481 ProteinModelPortal P77481 http://www.proteinmodelportal.org/query/uniprot/P77481 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9721282 http://www.ncbi.nlm.nih.gov/pubmed/9721282 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P77481 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77481 STRING 316407.1742155 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.1742155&targetmode=cogs SUPFAM SSF50331 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50331 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.1.46 http://www.tcdb.org/search/result.php?tc=3.A.1.1.46 UniProtKB YCJV_ECOLI http://www.uniprot.org/uniprot/YCJV_ECOLI UniProtKB-AC P77481 http://www.uniprot.org/uniprot/P77481 charge swissprot:YCJV_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCJV_ECOLI eggNOG COG3839 http://eggnogapi.embl.de/nog_data/html/tree/COG3839 eggNOG ENOG4108IJ9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108IJ9 epestfind swissprot:YCJV_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCJV_ECOLI garnier swissprot:YCJV_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCJV_ECOLI helixturnhelix swissprot:YCJV_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCJV_ECOLI hmoment swissprot:YCJV_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCJV_ECOLI iep swissprot:YCJV_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCJV_ECOLI inforesidue swissprot:YCJV_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCJV_ECOLI octanol swissprot:YCJV_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCJV_ECOLI pepcoil swissprot:YCJV_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCJV_ECOLI pepdigest swissprot:YCJV_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCJV_ECOLI pepinfo swissprot:YCJV_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCJV_ECOLI pepnet swissprot:YCJV_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCJV_ECOLI pepstats swissprot:YCJV_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCJV_ECOLI pepwheel swissprot:YCJV_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCJV_ECOLI pepwindow swissprot:YCJV_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCJV_ECOLI sigcleave swissprot:YCJV_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCJV_ECOLI ## Database ID URL or Descriptions # AltName PEPQ_ECOLI Imidodipeptidase # AltName PEPQ_ECOLI Proline dipeptidase # BIOPHYSICOCHEMICAL PROPERTIES PEPQ_ECOLI Kinetic parameters KM=1.9 mM for Ala-Pro {ECO 0000269|PubMed 15313226}; KM=0.10 mM for Arg-Pro {ECO 0000269|PubMed 15313226}; KM=1.4 mM for Gly-Pro {ECO 0000269|PubMed 15313226}; KM=0.15 mM for His-Pro {ECO 0000269|PubMed 15313226}; KM=0.10 mM for Ile-Pro {ECO 0000269|PubMed 15313226}; KM=1.0 mM for Leu-Pro {ECO 0000269|PubMed 15313226}; KM=0.27 mM for Lys-Pro {ECO 0000269|PubMed 15313226}; KM=0.13 mM for Met-Pro {ECO 0000269|PubMed 15313226}; KM=0.43 mM for Phe-Pro {ECO 0000269|PubMed 15313226}; KM=0.31 mM for Pro-Pro {ECO 0000269|PubMed 15313226}; KM=0.46 mM for Ser-Pro {ECO 0000269|PubMed 15313226}; KM=0.16 mM for Tyr-Pro {ECO 0000269|PubMed 15313226}; KM=0.40 mM for Val-Pro {ECO 0000269|PubMed 15313226}; KM=38 mM for diisopropylfluorophosphate {ECO 0000269|PubMed 15313226}; Note=Among the dipeptides described above, the highest catalytic efficiency is observed with dipeptides containing charge residues.; # BIOTECHNOLOGY PEPQ_ECOLI Can be utilized for the kinetic resolution of racemic phosphate esters. # BioGrid 4261838 11 # CATALYTIC ACTIVITY PEPQ_ECOLI Hydrolysis of Xaa-|-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-|-Pro. # COFACTOR PEPQ_ECOLI Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000250}; Note=Binds 2 manganese ions per subunit. {ECO 0000250}; # EcoGene EG10698 pepQ # FUNCTION PEPQ_ECOLI Splits dipeptides with a prolyl residue in the C- terminal position and a polar or nonpolar amino acid at the N- terminal position. With much lower efficiency, also catalyzes the stereoselective hydrolysis of a wide variety of organophosphate triesters and organophosphonate diesters. Is able to hydrolyze the organophosphorus insecticide paraoxon and the p-nitrophenyl analogs of the nerve agents GB (sarin), GD (soman), GF, Vx and rVX. {ECO 0000269|PubMed 15313226}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0016795 phosphoric triester hydrolase activity; IEA:InterPro. # GO_function GO:0016805 dipeptidase activity; IDA:EcoCyc. # GO_function GO:0030145 manganese ion binding; IDA:EcoCyc. # GO_function GO:0070573 metallodipeptidase activity; IDA:EcoCyc. # GO_function GO:0102009 proline dipeptidase activity; IEA:UniProtKB-EC. # GO_process GO:0043171 peptide catabolic process; IGI:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.90.230.10 -; 1. # HAMAP MF_01279 X_Pro_dipeptid # IntAct P21165 4 # InterPro IPR000994 Pept_M24 # InterPro IPR001131 Peptidase_M24B_aminopep-P_CS # InterPro IPR022846 X_Pro_dipept # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # MISCELLANEOUS PEPQ_ECOLI Has a stereoselective preference for isomers with R-configuration at the phosphorous center of organophosphonate diesters and with S-configuration in organophosphate triesters. # Organism PEPQ_ECOLI Escherichia coli (strain K12) # PATRIC 32123191 VBIEscCol129921_3961 # PDB 4QR8 X-ray; 2.00 A; A/B=1-443 # PIR H65189 H65189 # PROSITE PS00491 PROLINE_PEPTIDASE # Pfam PF00557 Peptidase_M24 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PEPQ_ECOLI Xaa-Pro dipeptidase # RefSeq NP_418289 NC_000913.3 # RefSeq WP_000444561 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA38501.1; Type=Frameshift; Positions=430; Note=The resulting sequence is much longer and includes the sequence of yigZ.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the peptidase M24B family. Bacterial-type prolidase subfamily. {ECO 0000305}. # SUPFAM SSF55920 SSF55920 # eggNOG COG0006 LUCA # eggNOG ENOG4105D9Y Bacteria BLAST swissprot:PEPQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PEPQ_ECOLI BioCyc ECOL316407:JW3823-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3823-MONOMER BioCyc EcoCyc:EG10698-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10698-MONOMER BioCyc MetaCyc:EG10698-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10698-MONOMER COG COG0006 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0006 DIP DIP-10460N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10460N DOI 10.1016/j.abb.2004.06.022 http://dx.doi.org/10.1016/j.abb.2004.06.022 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/18.21.6439 http://dx.doi.org/10.1093/nar/18.21.6439 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.13.9 http://www.genome.jp/dbget-bin/www_bget?EC:3.4.13.9 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X52837 http://www.ebi.ac.uk/ena/data/view/X52837 EMBL X54687 http://www.ebi.ac.uk/ena/data/view/X54687 ENZYME 3.4.13.9 http://enzyme.expasy.org/EC/3.4.13.9 EchoBASE EB0692 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0692 EcoGene EG10698 http://www.ecogene.org/geneInfo.php?eg_id=EG10698 EnsemblBacteria AAC76850 http://www.ensemblgenomes.org/id/AAC76850 EnsemblBacteria AAC76850 http://www.ensemblgenomes.org/id/AAC76850 EnsemblBacteria BAE77456 http://www.ensemblgenomes.org/id/BAE77456 EnsemblBacteria BAE77456 http://www.ensemblgenomes.org/id/BAE77456 EnsemblBacteria BAE77456 http://www.ensemblgenomes.org/id/BAE77456 EnsemblBacteria b3847 http://www.ensemblgenomes.org/id/b3847 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0016795 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016795 GO_function GO:0016805 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016805 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_function GO:0070573 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070573 GO_function GO:0102009 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0102009 GO_process GO:0043171 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043171 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.90.230.10 http://www.cathdb.info/version/latest/superfamily/3.90.230.10 GeneID 948335 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948335 HAMAP MF_01279 http://hamap.expasy.org/unirule/MF_01279 HOGENOM HOG000290531 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000290531&db=HOGENOM6 InParanoid P21165 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P21165 IntAct P21165 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P21165* IntEnz 3.4.13.9 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.13.9 InterPro IPR000994 http://www.ebi.ac.uk/interpro/entry/IPR000994 InterPro IPR001131 http://www.ebi.ac.uk/interpro/entry/IPR001131 InterPro IPR022846 http://www.ebi.ac.uk/interpro/entry/IPR022846 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW3823 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3823 KEGG_Gene eco:b3847 http://www.genome.jp/dbget-bin/www_bget?eco:b3847 KEGG_Orthology KO:K01271 http://www.genome.jp/dbget-bin/www_bget?KO:K01271 MINT MINT-1302254 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1302254 OMA MQDDTGT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MQDDTGT PDB 4QR8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4QR8 PDBsum 4QR8 http://www.ebi.ac.uk/pdbsum/4QR8 PROSITE PS00491 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00491 PSORT swissprot:PEPQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PEPQ_ECOLI PSORT-B swissprot:PEPQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PEPQ_ECOLI PSORT2 swissprot:PEPQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PEPQ_ECOLI Pfam PF00557 http://pfam.xfam.org/family/PF00557 Phobius swissprot:PEPQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PEPQ_ECOLI PhylomeDB P21165 http://phylomedb.org/?seqid=P21165 ProteinModelPortal P21165 http://www.proteinmodelportal.org/query/uniprot/P21165 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 15313226 http://www.ncbi.nlm.nih.gov/pubmed/15313226 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2243799 http://www.ncbi.nlm.nih.gov/pubmed/2243799 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418289 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418289 RefSeq WP_000444561 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000444561 SMR P21165 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P21165 STRING 511145.b3847 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3847&targetmode=cogs STRING COG0006 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0006&targetmode=cogs SUPFAM SSF55920 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55920 SWISS-2DPAGE P21165 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P21165 UniProtKB PEPQ_ECOLI http://www.uniprot.org/uniprot/PEPQ_ECOLI UniProtKB-AC P21165 http://www.uniprot.org/uniprot/P21165 charge swissprot:PEPQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PEPQ_ECOLI eggNOG COG0006 http://eggnogapi.embl.de/nog_data/html/tree/COG0006 eggNOG ENOG4105D9Y http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D9Y epestfind swissprot:PEPQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PEPQ_ECOLI garnier swissprot:PEPQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PEPQ_ECOLI helixturnhelix swissprot:PEPQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PEPQ_ECOLI hmoment swissprot:PEPQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PEPQ_ECOLI iep swissprot:PEPQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PEPQ_ECOLI inforesidue swissprot:PEPQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PEPQ_ECOLI octanol swissprot:PEPQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PEPQ_ECOLI pepcoil swissprot:PEPQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PEPQ_ECOLI pepdigest swissprot:PEPQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PEPQ_ECOLI pepinfo swissprot:PEPQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PEPQ_ECOLI pepnet swissprot:PEPQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PEPQ_ECOLI pepstats swissprot:PEPQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PEPQ_ECOLI pepwheel swissprot:PEPQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PEPQ_ECOLI pepwindow swissprot:PEPQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PEPQ_ECOLI sigcleave swissprot:PEPQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PEPQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4261214 181 # EcoGene EG14088 yfaZ # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # Gene3D 2.40.160.10 -; 1. # InterPro IPR009998 YfaZ # InterPro IPR011250 OMP/PagP_b-brl # InterPro IPR023614 Porin_dom # Organism YFAZ_ECOLI Escherichia coli (strain K12) # PATRIC 32119863 VBIEscCol129921_2341 # PIR H64995 H64995 # Pfam PF07437 YfaZ # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFAZ_ECOLI Uncharacterized protein YfaZ # RefSeq NP_416753 NC_000913.3 # RefSeq WP_001300392 NZ_LN832404.1 # SUPFAM SSF56925 SSF56925 # eggNOG ENOG4108UII Bacteria # eggNOG ENOG4111KP3 LUCA BLAST swissprot:YFAZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFAZ_ECOLI BioCyc ECOL316407:JW5371-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5371-MONOMER BioCyc EcoCyc:G7163-MONOMER http://biocyc.org/getid?id=EcoCyc:G7163-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3841 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3841 EcoGene EG14088 http://www.ecogene.org/geneInfo.php?eg_id=EG14088 EnsemblBacteria AAC75310 http://www.ensemblgenomes.org/id/AAC75310 EnsemblBacteria AAC75310 http://www.ensemblgenomes.org/id/AAC75310 EnsemblBacteria BAE76672 http://www.ensemblgenomes.org/id/BAE76672 EnsemblBacteria BAE76672 http://www.ensemblgenomes.org/id/BAE76672 EnsemblBacteria BAE76672 http://www.ensemblgenomes.org/id/BAE76672 EnsemblBacteria b2250 http://www.ensemblgenomes.org/id/b2250 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 Gene3D 2.40.160.10 http://www.cathdb.info/version/latest/superfamily/2.40.160.10 GeneID 946739 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946739 HOGENOM HOG000122411 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122411&db=HOGENOM6 InterPro IPR009998 http://www.ebi.ac.uk/interpro/entry/IPR009998 InterPro IPR011250 http://www.ebi.ac.uk/interpro/entry/IPR011250 InterPro IPR023614 http://www.ebi.ac.uk/interpro/entry/IPR023614 KEGG_Gene ecj:JW5371 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5371 KEGG_Gene eco:b2250 http://www.genome.jp/dbget-bin/www_bget?eco:b2250 OMA YINMASG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YINMASG PSORT swissprot:YFAZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFAZ_ECOLI PSORT-B swissprot:YFAZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFAZ_ECOLI PSORT2 swissprot:YFAZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFAZ_ECOLI Pfam PF07437 http://pfam.xfam.org/family/PF07437 Phobius swissprot:YFAZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFAZ_ECOLI ProteinModelPortal P76471 http://www.proteinmodelportal.org/query/uniprot/P76471 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416753 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416753 RefSeq WP_001300392 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300392 STRING 511145.b2250 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2250&targetmode=cogs SUPFAM SSF56925 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56925 UniProtKB YFAZ_ECOLI http://www.uniprot.org/uniprot/YFAZ_ECOLI UniProtKB-AC P76471 http://www.uniprot.org/uniprot/P76471 charge swissprot:YFAZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFAZ_ECOLI eggNOG ENOG4108UII http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UII eggNOG ENOG4111KP3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111KP3 epestfind swissprot:YFAZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFAZ_ECOLI garnier swissprot:YFAZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFAZ_ECOLI helixturnhelix swissprot:YFAZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFAZ_ECOLI hmoment swissprot:YFAZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFAZ_ECOLI iep swissprot:YFAZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFAZ_ECOLI inforesidue swissprot:YFAZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFAZ_ECOLI octanol swissprot:YFAZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFAZ_ECOLI pepcoil swissprot:YFAZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFAZ_ECOLI pepdigest swissprot:YFAZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFAZ_ECOLI pepinfo swissprot:YFAZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFAZ_ECOLI pepnet swissprot:YFAZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFAZ_ECOLI pepstats swissprot:YFAZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFAZ_ECOLI pepwheel swissprot:YFAZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFAZ_ECOLI pepwindow swissprot:YFAZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFAZ_ECOLI sigcleave swissprot:YFAZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFAZ_ECOLI ## Database ID URL or Descriptions # BioGrid 4261199 429 # CATALYTIC ACTIVITY (R,R)-tartrate = oxaloacetate + H(2)O. {ECO:0000269|PubMed 8371115}. # EcoGene EG11169 ttdB # GO_function GO:0008730 L(+)-tartrate dehydratase activity; IEA:UniProtKB-EC. # GO_process GO:0009408 response to heat; IMP:EcoCyc. # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0006950 response to stress # Gene3D 3.20.130.10 -; 1. # INDUCTION Induced by tartrate, via TtdR. {ECO:0000269|PubMed 16804186}. # IntAct P0AC35 2 # InterPro IPR004647 Fe-S_hydro-lyase_TtdB-typ_cat # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00630 Glyoxylate and dicarboxylate metabolism # Organism TTDB_ECOLI Escherichia coli (strain K12) # PATRIC 32121538 VBIEscCol129921_3156 # PIR D65094 QQECRZ # Pfam PF05683 Fumerase_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TTDB_ECOLI L(+)-tartrate dehydratase subunit beta # RefSeq NP_417534 NC_000913.3 # RefSeq WP_000722957 NZ_CP014272.1 # SIMILARITY Belongs to the class-I fumarase family. {ECO 0000305}. # SUBUNIT Heterotetramer of two alpha and two beta subunits. {ECO:0000305|PubMed 8371115}. # SUPFAM SSF117457 SSF117457 # TIGRFAMs TIGR00723 ttdB_fumA_fumB # eggNOG COG1838 LUCA # eggNOG ENOG4107GFK Bacteria BLAST swissprot:TTDB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TTDB_ECOLI BioCyc ECOL316407:JW3034-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3034-MONOMER BioCyc EcoCyc:TTDB-MONOMER http://biocyc.org/getid?id=EcoCyc:TTDB-MONOMER BioCyc MetaCyc:TTDB-MONOMER http://biocyc.org/getid?id=MetaCyc:TTDB-MONOMER COG COG1838 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1838 DOI 10.1016/0378-1119(87)90303-9 http://dx.doi.org/10.1016/0378-1119(87)90303-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1099/00221287-139-7-1523 http://dx.doi.org/10.1099/00221287-139-7-1523 DOI 10.1099/mic.0.28753-0 http://dx.doi.org/10.1099/mic.0.28753-0 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.1.32 http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.32 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L14781 http://www.ebi.ac.uk/ena/data/view/L14781 EMBL M16194 http://www.ebi.ac.uk/ena/data/view/M16194 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28379 http://www.ebi.ac.uk/ena/data/view/U28379 ENZYME 4.2.1.32 http://enzyme.expasy.org/EC/4.2.1.32 EchoBASE EB1157 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1157 EcoGene EG11169 http://www.ecogene.org/geneInfo.php?eg_id=EG11169 EnsemblBacteria AAC76098 http://www.ensemblgenomes.org/id/AAC76098 EnsemblBacteria AAC76098 http://www.ensemblgenomes.org/id/AAC76098 EnsemblBacteria BAE77113 http://www.ensemblgenomes.org/id/BAE77113 EnsemblBacteria BAE77113 http://www.ensemblgenomes.org/id/BAE77113 EnsemblBacteria BAE77113 http://www.ensemblgenomes.org/id/BAE77113 EnsemblBacteria b3062 http://www.ensemblgenomes.org/id/b3062 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008730 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008730 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.20.130.10 http://www.cathdb.info/version/latest/superfamily/3.20.130.10 GeneID 947568 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947568 HOGENOM HOG000225718 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000225718&db=HOGENOM6 InParanoid P0AC35 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AC35 IntAct P0AC35 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AC35* IntEnz 4.2.1.32 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.32 InterPro IPR004647 http://www.ebi.ac.uk/interpro/entry/IPR004647 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3034 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3034 KEGG_Gene eco:b3062 http://www.genome.jp/dbget-bin/www_bget?eco:b3062 KEGG_Orthology KO:K03780 http://www.genome.jp/dbget-bin/www_bget?KO:K03780 KEGG_Pathway ko00630 http://www.genome.jp/kegg-bin/show_pathway?ko00630 KEGG_Reaction rn:R00339 http://www.genome.jp/dbget-bin/www_bget?rn:R00339 OMA IYHAGPI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IYHAGPI PSORT swissprot:TTDB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TTDB_ECOLI PSORT-B swissprot:TTDB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TTDB_ECOLI PSORT2 swissprot:TTDB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TTDB_ECOLI Pfam PF05683 http://pfam.xfam.org/family/PF05683 Phobius swissprot:TTDB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TTDB_ECOLI PhylomeDB P0AC35 http://phylomedb.org/?seqid=P0AC35 ProteinModelPortal P0AC35 http://www.proteinmodelportal.org/query/uniprot/P0AC35 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16804186 http://www.ncbi.nlm.nih.gov/pubmed/16804186 PubMed 3297921 http://www.ncbi.nlm.nih.gov/pubmed/3297921 PubMed 8371115 http://www.ncbi.nlm.nih.gov/pubmed/8371115 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417534 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417534 RefSeq WP_000722957 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000722957 SMR P0AC35 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AC35 STRING 511145.b3062 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3062&targetmode=cogs STRING COG1838 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1838&targetmode=cogs SUPFAM SSF117457 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF117457 TIGRFAMs TIGR00723 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00723 UniProtKB TTDB_ECOLI http://www.uniprot.org/uniprot/TTDB_ECOLI UniProtKB-AC P0AC35 http://www.uniprot.org/uniprot/P0AC35 charge swissprot:TTDB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TTDB_ECOLI eggNOG COG1838 http://eggnogapi.embl.de/nog_data/html/tree/COG1838 eggNOG ENOG4107GFK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107GFK epestfind swissprot:TTDB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TTDB_ECOLI garnier swissprot:TTDB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TTDB_ECOLI helixturnhelix swissprot:TTDB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TTDB_ECOLI hmoment swissprot:TTDB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TTDB_ECOLI iep swissprot:TTDB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TTDB_ECOLI inforesidue swissprot:TTDB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TTDB_ECOLI octanol swissprot:TTDB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TTDB_ECOLI pepcoil swissprot:TTDB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TTDB_ECOLI pepdigest swissprot:TTDB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TTDB_ECOLI pepinfo swissprot:TTDB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TTDB_ECOLI pepnet swissprot:TTDB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TTDB_ECOLI pepstats swissprot:TTDB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TTDB_ECOLI pepwheel swissprot:TTDB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TTDB_ECOLI pepwindow swissprot:TTDB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TTDB_ECOLI sigcleave swissprot:TTDB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TTDB_ECOLI ## Database ID URL or Descriptions # BRENDA 1.5.1 2026 # BioGrid 4262199 282 # CATALYTIC ACTIVITY DYR_ECOLI 5,6,7,8-tetrahydrofolate + NADP(+) = 7,8- dihydrofolate + NADPH. {ECO 0000255|PROSITE-ProRule PRU00660, ECO 0000269|PubMed 16510443}. # CDD cd00209 DHFR # DrugBank DB03904 Urea # EcoGene EG10326 folA # FUNCTION DYR_ECOLI Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004146 dihydrofolate reductase activity; IDA:EcoCyc. # GO_function GO:0050661 NADP binding; IEA:InterPro. # GO_process GO:0006545 glycine biosynthetic process; IEA:InterPro. # GO_process GO:0006730 one-carbon metabolic process; IEA:UniProtKB-KW. # GO_process GO:0009165 nucleotide biosynthetic process; IEA:InterPro. # GO_process GO:0031427 response to methotrexate; IEA:UniProtKB-KW. # GO_process GO:0042493 response to drug; IDA:EcoliWiki. # GO_process GO:0046654 tetrahydrofolate biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.430.10 -; 1. # INTERACTION DYR_ECOLI P77609 flxA; NbExp=4; IntAct=EBI-550404, EBI-553024; # IntAct P0ABQ4 16 # InterPro IPR001796 DHFR_dom # InterPro IPR012259 DHFR # InterPro IPR017925 DHFR_CS # InterPro IPR024072 DHFR-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00670 One carbon pool by folate # KEGG_Pathway ko00790 Folate biosynthesis # MISCELLANEOUS DYR_ECOLI Strain B [MB1428] is methotrexate-resistant. # MISCELLANEOUS DYR_ECOLI Strain B [RT500] is resistant to 500 micrograms per milliliter of trimethoprim. # MISCELLANEOUS DYR_ECOLI The strain K12 sequence is shown. # Organism DYR_ECOLI Escherichia coli (strain K12) # PATHWAY Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate step 1/1. # PATRIC 32115195 VBIEscCol129921_0049 # PDB 1DDR X-ray; 2.45 A; A/B=1-159 # PDB 1DDS X-ray; 2.20 A; A/B=1-159 # PDB 1DHI X-ray; 1.90 A; A/B=1-159 # PDB 1DHJ X-ray; 1.80 A; A/B=1-159 # PDB 1DRA X-ray; 1.90 A; A/B=1-159 # PDB 1DRB X-ray; 1.96 A; A/B=1-159 # PDB 1DRE X-ray; 2.60 A; A=1-159 # PDB 1DRH X-ray; 2.30 A; A=1-159 # PDB 1DYH X-ray; 1.90 A; A/B=1-159 # PDB 1DYI X-ray; 1.90 A; A/B=1-159 # PDB 1DYJ X-ray; 1.85 A; A/B=1-159 # PDB 1JOL X-ray; 1.96 A; A/B=1-159 # PDB 1JOM X-ray; 1.90 A; A=1-159 # PDB 1RA1 X-ray; 1.90 A; A=1-159 # PDB 1RA2 X-ray; 1.60 A; A=1-159 # PDB 1RA3 X-ray; 1.80 A; A=1-159 # PDB 1RA8 X-ray; 1.80 A; A=1-159 # PDB 1RA9 X-ray; 1.55 A; A=1-159 # PDB 1RB2 X-ray; 2.10 A; A/B=1-159 # PDB 1RB3 X-ray; 2.30 A; A/B=1-159 # PDB 1RC4 X-ray; 1.90 A; A=1-159 # PDB 1RD7 X-ray; 2.60 A; A/B=1-159 # PDB 1RE7 X-ray; 2.60 A; A/B=1-159 # PDB 1RF7 X-ray; 1.80 A; A=1-159 # PDB 1RG7 X-ray; 2.00 A; A=1-159 # PDB 1RH3 X-ray; 2.40 A; A=1-159 # PDB 1RX1 X-ray; 2.00 A; A=1-159 # PDB 1RX2 X-ray; 1.80 A; A=1-159 # PDB 1RX3 X-ray; 2.20 A; A=1-159 # PDB 1RX4 X-ray; 2.20 A; A=1-159 # PDB 1RX5 X-ray; 2.30 A; A=1-159 # PDB 1RX6 X-ray; 2.00 A; A=1-159 # PDB 1RX7 X-ray; 2.30 A; A=1-159 # PDB 1RX8 X-ray; 2.80 A; A=1-159 # PDB 1RX9 X-ray; 1.90 A; A=1-159 # PDB 1TDR X-ray; 2.50 A; A/B=1-159 # PDB 2ANO X-ray; 2.68 A; A=1-159 # PDB 2ANQ X-ray; 2.13 A; A=1-159 # PDB 2D0K X-ray; 1.90 A; A/B=2-159 # PDB 2DRC X-ray; 1.90 A; A/B=1-159 # PDB 2INQ Neutron; 2.20 A; A/B=1-159 # PDB 3DAU X-ray; 1.50 A; A=1-159 # PDB 3DRC X-ray; 1.90 A; A/B=1-159 # PDB 3K74 X-ray; 1.95 A; A=1-159 # PDB 3KFY X-ray; 2.08 A; A=1-159 # PDB 3OCH X-ray; 1.79 A; A/B=1-159 # PDB 3QL3 X-ray; 1.80 A; A=1-159 # PDB 3QYL X-ray; 1.79 A; A=1-159 # PDB 3QYO X-ray; 2.09 A; A=1-159 # PDB 3R33 X-ray; 2.09 A; A=1-159 # PDB 4DFR X-ray; 1.70 A; A/B=1-159 # PDB 4EIG X-ray; 2.50 A; A=1-159 # PDB 4EIZ X-ray; 2.20 A; A/B=1-159 # PDB 4EJ1 X-ray; 1.75 A; A/B=1-159 # PDB 4FHB X-ray; 2.80 A; A=1-159 # PDB 4GH8 X-ray; 1.85 A; A/B=1-158 # PDB 4I13 X-ray; 1.60 A; A=1-159 # PDB 4I1N X-ray; 1.89 A; A=1-159 # PDB 4KJJ X-ray; 1.15 A; A=1-159 # PDB 4KJK X-ray; 1.35 A; A=1-159 # PDB 4KJL X-ray; 1.38 A; A=1-159 # PDB 4NX6 X-ray; 1.35 A; A=1-159 # PDB 4NX7 X-ray; 1.15 A; A=1-159 # PDB 4PDJ Other; 1.60 A; A=1-159 # PDB 4X5F X-ray; 1.70 A; A/B=1-159 # PDB 4X5G X-ray; 1.90 A; A/B=1-159 # PDB 4X5H X-ray; 1.90 A; A=1-159 # PDB 4X5I X-ray; 1.80 A; A=1-159 # PDB 4X5J X-ray; 1.85 A; A=1-159 # PDB 5CC9 X-ray; 1.20 A; A=1-159 # PDB 5CCC X-ray; 1.50 A; A=1-159 # PDB 5DFR X-ray; 2.30 A; A=1-159 # PDB 5E8Q X-ray; 1.80 A; A/B=1-159 # PDB 5EAJ X-ray; 1.70 A; A/B=1-159 # PDB 6DFR X-ray; 2.40 A; A=1-159 # PDB 7DFR X-ray; 2.50 A; A=1-159 # PIR A93704 RDECD # PIRSF PIRSF000194 DHFR # PRINTS PR00070 DHFR # PROSITE PS00075 DHFR_1 # PROSITE PS51330 DHFR_2 # Pfam PF00186 DHFR_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DYR_ECOLI Dihydrofolate reductase # RefSeq NP_414590 NC_000913.3 # RefSeq WP_000624375 NZ_LN832404.1 # SIMILARITY Belongs to the dihydrofolate reductase family. {ECO 0000305}. # SIMILARITY Contains 1 DHFR (dihydrofolate reductase) domain. {ECO:0000255|PROSITE-ProRule PRU00660}. # SUPFAM SSF53597 SSF53597 # UniPathway UPA00077 UER00158 # eggNOG COG0262 LUCA # eggNOG ENOG4108YYV Bacteria BLAST swissprot:DYR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DYR_ECOLI BioCyc ECOL316407:JW0047-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0047-MONOMER BioCyc EcoCyc:DIHYDROFOLATEREDUCT-MONOMER http://biocyc.org/getid?id=EcoCyc:DIHYDROFOLATEREDUCT-MONOMER BioCyc MetaCyc:DIHYDROFOLATEREDUCT-MONOMER http://biocyc.org/getid?id=MetaCyc:DIHYDROFOLATEREDUCT-MONOMER COG COG0262 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0262 DIP DIP-35824N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35824N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/j.jsb.2009.01.001 http://dx.doi.org/10.1016/j.jsb.2009.01.001 DOI 10.1021/bi00008a039 http://dx.doi.org/10.1021/bi00008a039 DOI 10.1021/bi00222a028 http://dx.doi.org/10.1021/bi00222a028 DOI 10.1021/bi00465a018 http://dx.doi.org/10.1021/bi00465a018 DOI 10.1021/bi00600a030 http://dx.doi.org/10.1021/bi00600a030 DOI 10.1021/bi960028g http://dx.doi.org/10.1021/bi960028g DOI 10.1021/bi962337c http://dx.doi.org/10.1021/bi962337c DOI 10.1021/jm060570v http://dx.doi.org/10.1021/jm060570v DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0604977103 http://dx.doi.org/10.1073/pnas.0604977103 DOI 10.1074/jbc.M508823200 http://dx.doi.org/10.1074/jbc.M508823200 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1093/nar/8.10.2255 http://dx.doi.org/10.1093/nar/8.10.2255 DOI 10.1111/j.1432-1033.1977.tb11284.x http://dx.doi.org/10.1111/j.1432-1033.1977.tb11284.x DOI 10.1111/j.1432-1033.1987.tb10664.x http://dx.doi.org/10.1111/j.1432-1033.1987.tb10664.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DisProt DP00301 http://www.disprot.org/protein.php?id=DP00301 DrugBank DB03904 http://www.drugbank.ca/drugs/DB03904 EC_number EC:1.5.1.3 http://www.genome.jp/dbget-bin/www_bget?EC:1.5.1.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01609 http://www.ebi.ac.uk/ena/data/view/J01609 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X05108 http://www.ebi.ac.uk/ena/data/view/X05108 ENZYME 1.5.1.3 http://enzyme.expasy.org/EC/1.5.1.3 EchoBASE EB0322 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0322 EcoGene EG10326 http://www.ecogene.org/geneInfo.php?eg_id=EG10326 EnsemblBacteria AAC73159 http://www.ensemblgenomes.org/id/AAC73159 EnsemblBacteria AAC73159 http://www.ensemblgenomes.org/id/AAC73159 EnsemblBacteria BAB96616 http://www.ensemblgenomes.org/id/BAB96616 EnsemblBacteria BAB96616 http://www.ensemblgenomes.org/id/BAB96616 EnsemblBacteria BAB96616 http://www.ensemblgenomes.org/id/BAB96616 EnsemblBacteria b0048 http://www.ensemblgenomes.org/id/b0048 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004146 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004146 GO_function GO:0050661 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050661 GO_process GO:0006545 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006545 GO_process GO:0006730 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006730 GO_process GO:0009165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009165 GO_process GO:0031427 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031427 GO_process GO:0042493 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493 GO_process GO:0046654 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046654 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.430.10 http://www.cathdb.info/version/latest/superfamily/3.40.430.10 GeneID 944790 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944790 HOGENOM HOG000040233 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000040233&db=HOGENOM6 InParanoid P0ABQ4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABQ4 IntAct P0ABQ4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABQ4* IntEnz 1.5.1.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.5.1.3 InterPro IPR001796 http://www.ebi.ac.uk/interpro/entry/IPR001796 InterPro IPR012259 http://www.ebi.ac.uk/interpro/entry/IPR012259 InterPro IPR017925 http://www.ebi.ac.uk/interpro/entry/IPR017925 InterPro IPR024072 http://www.ebi.ac.uk/interpro/entry/IPR024072 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0047 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0047 KEGG_Gene eco:b0048 http://www.genome.jp/dbget-bin/www_bget?eco:b0048 KEGG_Orthology KO:K00287 http://www.genome.jp/dbget-bin/www_bget?KO:K00287 KEGG_Pathway ko00670 http://www.genome.jp/kegg-bin/show_pathway?ko00670 KEGG_Pathway ko00790 http://www.genome.jp/kegg-bin/show_pathway?ko00790 KEGG_Reaction rn:R00936 http://www.genome.jp/dbget-bin/www_bget?rn:R00936 KEGG_Reaction rn:R00937 http://www.genome.jp/dbget-bin/www_bget?rn:R00937 KEGG_Reaction rn:R00939 http://www.genome.jp/dbget-bin/www_bget?rn:R00939 KEGG_Reaction rn:R00940 http://www.genome.jp/dbget-bin/www_bget?rn:R00940 KEGG_Reaction rn:R02235 http://www.genome.jp/dbget-bin/www_bget?rn:R02235 KEGG_Reaction rn:R02236 http://www.genome.jp/dbget-bin/www_bget?rn:R02236 MINT MINT-1239602 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1239602 OMA MCITHVE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MCITHVE PDB 1DDR http://www.ebi.ac.uk/pdbe-srv/view/entry/1DDR PDB 1DDS http://www.ebi.ac.uk/pdbe-srv/view/entry/1DDS PDB 1DHI http://www.ebi.ac.uk/pdbe-srv/view/entry/1DHI PDB 1DHJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1DHJ PDB 1DRA http://www.ebi.ac.uk/pdbe-srv/view/entry/1DRA PDB 1DRB http://www.ebi.ac.uk/pdbe-srv/view/entry/1DRB PDB 1DRE http://www.ebi.ac.uk/pdbe-srv/view/entry/1DRE PDB 1DRH http://www.ebi.ac.uk/pdbe-srv/view/entry/1DRH PDB 1DYH http://www.ebi.ac.uk/pdbe-srv/view/entry/1DYH PDB 1DYI http://www.ebi.ac.uk/pdbe-srv/view/entry/1DYI PDB 1DYJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1DYJ PDB 1JOL http://www.ebi.ac.uk/pdbe-srv/view/entry/1JOL PDB 1JOM http://www.ebi.ac.uk/pdbe-srv/view/entry/1JOM PDB 1RA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1RA1 PDB 1RA2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1RA2 PDB 1RA3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1RA3 PDB 1RA8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1RA8 PDB 1RA9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1RA9 PDB 1RB2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1RB2 PDB 1RB3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1RB3 PDB 1RC4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1RC4 PDB 1RD7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1RD7 PDB 1RE7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1RE7 PDB 1RF7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1RF7 PDB 1RG7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1RG7 PDB 1RH3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1RH3 PDB 1RX1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1RX1 PDB 1RX2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1RX2 PDB 1RX3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1RX3 PDB 1RX4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1RX4 PDB 1RX5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1RX5 PDB 1RX6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1RX6 PDB 1RX7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1RX7 PDB 1RX8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1RX8 PDB 1RX9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1RX9 PDB 1TDR http://www.ebi.ac.uk/pdbe-srv/view/entry/1TDR PDB 2ANO http://www.ebi.ac.uk/pdbe-srv/view/entry/2ANO PDB 2ANQ http://www.ebi.ac.uk/pdbe-srv/view/entry/2ANQ PDB 2D0K http://www.ebi.ac.uk/pdbe-srv/view/entry/2D0K PDB 2DRC http://www.ebi.ac.uk/pdbe-srv/view/entry/2DRC PDB 2INQ http://www.ebi.ac.uk/pdbe-srv/view/entry/2INQ PDB 3DAU http://www.ebi.ac.uk/pdbe-srv/view/entry/3DAU PDB 3DRC http://www.ebi.ac.uk/pdbe-srv/view/entry/3DRC PDB 3K74 http://www.ebi.ac.uk/pdbe-srv/view/entry/3K74 PDB 3KFY http://www.ebi.ac.uk/pdbe-srv/view/entry/3KFY PDB 3OCH http://www.ebi.ac.uk/pdbe-srv/view/entry/3OCH PDB 3QL3 http://www.ebi.ac.uk/pdbe-srv/view/entry/3QL3 PDB 3QYL http://www.ebi.ac.uk/pdbe-srv/view/entry/3QYL PDB 3QYO http://www.ebi.ac.uk/pdbe-srv/view/entry/3QYO PDB 3R33 http://www.ebi.ac.uk/pdbe-srv/view/entry/3R33 PDB 4DFR http://www.ebi.ac.uk/pdbe-srv/view/entry/4DFR PDB 4EIG http://www.ebi.ac.uk/pdbe-srv/view/entry/4EIG PDB 4EIZ http://www.ebi.ac.uk/pdbe-srv/view/entry/4EIZ PDB 4EJ1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4EJ1 PDB 4FHB http://www.ebi.ac.uk/pdbe-srv/view/entry/4FHB PDB 4GH8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4GH8 PDB 4I13 http://www.ebi.ac.uk/pdbe-srv/view/entry/4I13 PDB 4I1N http://www.ebi.ac.uk/pdbe-srv/view/entry/4I1N PDB 4KJJ http://www.ebi.ac.uk/pdbe-srv/view/entry/4KJJ PDB 4KJK http://www.ebi.ac.uk/pdbe-srv/view/entry/4KJK PDB 4KJL http://www.ebi.ac.uk/pdbe-srv/view/entry/4KJL PDB 4NX6 http://www.ebi.ac.uk/pdbe-srv/view/entry/4NX6 PDB 4NX7 http://www.ebi.ac.uk/pdbe-srv/view/entry/4NX7 PDB 4PDJ http://www.ebi.ac.uk/pdbe-srv/view/entry/4PDJ PDB 4X5F http://www.ebi.ac.uk/pdbe-srv/view/entry/4X5F PDB 4X5G http://www.ebi.ac.uk/pdbe-srv/view/entry/4X5G PDB 4X5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4X5H PDB 4X5I http://www.ebi.ac.uk/pdbe-srv/view/entry/4X5I PDB 4X5J http://www.ebi.ac.uk/pdbe-srv/view/entry/4X5J PDB 5CC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5CC9 PDB 5CCC http://www.ebi.ac.uk/pdbe-srv/view/entry/5CCC PDB 5DFR http://www.ebi.ac.uk/pdbe-srv/view/entry/5DFR PDB 5E8Q http://www.ebi.ac.uk/pdbe-srv/view/entry/5E8Q PDB 5EAJ http://www.ebi.ac.uk/pdbe-srv/view/entry/5EAJ PDB 6DFR http://www.ebi.ac.uk/pdbe-srv/view/entry/6DFR PDB 7DFR http://www.ebi.ac.uk/pdbe-srv/view/entry/7DFR PDBsum 1DDR http://www.ebi.ac.uk/pdbsum/1DDR PDBsum 1DDS http://www.ebi.ac.uk/pdbsum/1DDS PDBsum 1DHI http://www.ebi.ac.uk/pdbsum/1DHI PDBsum 1DHJ http://www.ebi.ac.uk/pdbsum/1DHJ PDBsum 1DRA http://www.ebi.ac.uk/pdbsum/1DRA PDBsum 1DRB http://www.ebi.ac.uk/pdbsum/1DRB PDBsum 1DRE http://www.ebi.ac.uk/pdbsum/1DRE PDBsum 1DRH http://www.ebi.ac.uk/pdbsum/1DRH PDBsum 1DYH http://www.ebi.ac.uk/pdbsum/1DYH PDBsum 1DYI http://www.ebi.ac.uk/pdbsum/1DYI PDBsum 1DYJ http://www.ebi.ac.uk/pdbsum/1DYJ PDBsum 1JOL http://www.ebi.ac.uk/pdbsum/1JOL PDBsum 1JOM http://www.ebi.ac.uk/pdbsum/1JOM PDBsum 1RA1 http://www.ebi.ac.uk/pdbsum/1RA1 PDBsum 1RA2 http://www.ebi.ac.uk/pdbsum/1RA2 PDBsum 1RA3 http://www.ebi.ac.uk/pdbsum/1RA3 PDBsum 1RA8 http://www.ebi.ac.uk/pdbsum/1RA8 PDBsum 1RA9 http://www.ebi.ac.uk/pdbsum/1RA9 PDBsum 1RB2 http://www.ebi.ac.uk/pdbsum/1RB2 PDBsum 1RB3 http://www.ebi.ac.uk/pdbsum/1RB3 PDBsum 1RC4 http://www.ebi.ac.uk/pdbsum/1RC4 PDBsum 1RD7 http://www.ebi.ac.uk/pdbsum/1RD7 PDBsum 1RE7 http://www.ebi.ac.uk/pdbsum/1RE7 PDBsum 1RF7 http://www.ebi.ac.uk/pdbsum/1RF7 PDBsum 1RG7 http://www.ebi.ac.uk/pdbsum/1RG7 PDBsum 1RH3 http://www.ebi.ac.uk/pdbsum/1RH3 PDBsum 1RX1 http://www.ebi.ac.uk/pdbsum/1RX1 PDBsum 1RX2 http://www.ebi.ac.uk/pdbsum/1RX2 PDBsum 1RX3 http://www.ebi.ac.uk/pdbsum/1RX3 PDBsum 1RX4 http://www.ebi.ac.uk/pdbsum/1RX4 PDBsum 1RX5 http://www.ebi.ac.uk/pdbsum/1RX5 PDBsum 1RX6 http://www.ebi.ac.uk/pdbsum/1RX6 PDBsum 1RX7 http://www.ebi.ac.uk/pdbsum/1RX7 PDBsum 1RX8 http://www.ebi.ac.uk/pdbsum/1RX8 PDBsum 1RX9 http://www.ebi.ac.uk/pdbsum/1RX9 PDBsum 1TDR http://www.ebi.ac.uk/pdbsum/1TDR PDBsum 2ANO http://www.ebi.ac.uk/pdbsum/2ANO PDBsum 2ANQ http://www.ebi.ac.uk/pdbsum/2ANQ PDBsum 2D0K http://www.ebi.ac.uk/pdbsum/2D0K PDBsum 2DRC http://www.ebi.ac.uk/pdbsum/2DRC PDBsum 2INQ http://www.ebi.ac.uk/pdbsum/2INQ PDBsum 3DAU http://www.ebi.ac.uk/pdbsum/3DAU PDBsum 3DRC http://www.ebi.ac.uk/pdbsum/3DRC PDBsum 3K74 http://www.ebi.ac.uk/pdbsum/3K74 PDBsum 3KFY http://www.ebi.ac.uk/pdbsum/3KFY PDBsum 3OCH http://www.ebi.ac.uk/pdbsum/3OCH PDBsum 3QL3 http://www.ebi.ac.uk/pdbsum/3QL3 PDBsum 3QYL http://www.ebi.ac.uk/pdbsum/3QYL PDBsum 3QYO http://www.ebi.ac.uk/pdbsum/3QYO PDBsum 3R33 http://www.ebi.ac.uk/pdbsum/3R33 PDBsum 4DFR http://www.ebi.ac.uk/pdbsum/4DFR PDBsum 4EIG http://www.ebi.ac.uk/pdbsum/4EIG PDBsum 4EIZ http://www.ebi.ac.uk/pdbsum/4EIZ PDBsum 4EJ1 http://www.ebi.ac.uk/pdbsum/4EJ1 PDBsum 4FHB http://www.ebi.ac.uk/pdbsum/4FHB PDBsum 4GH8 http://www.ebi.ac.uk/pdbsum/4GH8 PDBsum 4I13 http://www.ebi.ac.uk/pdbsum/4I13 PDBsum 4I1N http://www.ebi.ac.uk/pdbsum/4I1N PDBsum 4KJJ http://www.ebi.ac.uk/pdbsum/4KJJ PDBsum 4KJK http://www.ebi.ac.uk/pdbsum/4KJK PDBsum 4KJL http://www.ebi.ac.uk/pdbsum/4KJL PDBsum 4NX6 http://www.ebi.ac.uk/pdbsum/4NX6 PDBsum 4NX7 http://www.ebi.ac.uk/pdbsum/4NX7 PDBsum 4PDJ http://www.ebi.ac.uk/pdbsum/4PDJ PDBsum 4X5F http://www.ebi.ac.uk/pdbsum/4X5F PDBsum 4X5G http://www.ebi.ac.uk/pdbsum/4X5G PDBsum 4X5H http://www.ebi.ac.uk/pdbsum/4X5H PDBsum 4X5I http://www.ebi.ac.uk/pdbsum/4X5I PDBsum 4X5J http://www.ebi.ac.uk/pdbsum/4X5J PDBsum 5CC9 http://www.ebi.ac.uk/pdbsum/5CC9 PDBsum 5CCC http://www.ebi.ac.uk/pdbsum/5CCC PDBsum 5DFR http://www.ebi.ac.uk/pdbsum/5DFR PDBsum 5E8Q http://www.ebi.ac.uk/pdbsum/5E8Q PDBsum 5EAJ http://www.ebi.ac.uk/pdbsum/5EAJ PDBsum 6DFR http://www.ebi.ac.uk/pdbsum/6DFR PDBsum 7DFR http://www.ebi.ac.uk/pdbsum/7DFR PRINTS PR00070 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00070 PROSITE PS00075 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00075 PROSITE PS51330 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51330 PSORT swissprot:DYR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DYR_ECOLI PSORT-B swissprot:DYR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DYR_ECOLI PSORT2 swissprot:DYR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DYR_ECOLI Pfam PF00186 http://pfam.xfam.org/family/PF00186 Phobius swissprot:DYR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DYR_ECOLI PhylomeDB P0ABQ4 http://phylomedb.org/?seqid=P0ABQ4 ProteinModelPortal P0ABQ4 http://www.proteinmodelportal.org/query/uniprot/P0ABQ4 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16510443 http://www.ncbi.nlm.nih.gov/pubmed/16510443 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17125251 http://www.ncbi.nlm.nih.gov/pubmed/17125251 PubMed 17130456 http://www.ncbi.nlm.nih.gov/pubmed/17130456 PubMed 19374017 http://www.ncbi.nlm.nih.gov/pubmed/19374017 PubMed 1998681 http://www.ncbi.nlm.nih.gov/pubmed/1998681 PubMed 2185835 http://www.ncbi.nlm.nih.gov/pubmed/2185835 PubMed 320005 http://www.ncbi.nlm.nih.gov/pubmed/320005 PubMed 350268 http://www.ncbi.nlm.nih.gov/pubmed/350268 PubMed 3549289 http://www.ncbi.nlm.nih.gov/pubmed/3549289 PubMed 6159575 http://www.ncbi.nlm.nih.gov/pubmed/6159575 PubMed 6815179 http://www.ncbi.nlm.nih.gov/pubmed/6815179 PubMed 7007370 http://www.ncbi.nlm.nih.gov/pubmed/7007370 PubMed 7873554 http://www.ncbi.nlm.nih.gov/pubmed/7873554 PubMed 8679526 http://www.ncbi.nlm.nih.gov/pubmed/8679526 PubMed 9012674 http://www.ncbi.nlm.nih.gov/pubmed/9012674 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_414590 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414590 RefSeq WP_000624375 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000624375 SMR P0ABQ4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABQ4 STRING 511145.b0048 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0048&targetmode=cogs STRING COG0262 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0262&targetmode=cogs SUPFAM SSF53597 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53597 SWISS-2DPAGE P0ABQ4 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0ABQ4 UniProtKB DYR_ECOLI http://www.uniprot.org/uniprot/DYR_ECOLI UniProtKB-AC P0ABQ4 http://www.uniprot.org/uniprot/P0ABQ4 charge swissprot:DYR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DYR_ECOLI eggNOG COG0262 http://eggnogapi.embl.de/nog_data/html/tree/COG0262 eggNOG ENOG4108YYV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108YYV epestfind swissprot:DYR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DYR_ECOLI garnier swissprot:DYR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DYR_ECOLI helixturnhelix swissprot:DYR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DYR_ECOLI hmoment swissprot:DYR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DYR_ECOLI iep swissprot:DYR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DYR_ECOLI inforesidue swissprot:DYR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DYR_ECOLI octanol swissprot:DYR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DYR_ECOLI pepcoil swissprot:DYR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DYR_ECOLI pepdigest swissprot:DYR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DYR_ECOLI pepinfo swissprot:DYR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DYR_ECOLI pepnet swissprot:DYR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DYR_ECOLI pepstats swissprot:DYR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DYR_ECOLI pepwheel swissprot:DYR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DYR_ECOLI pepwindow swissprot:DYR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DYR_ECOLI sigcleave swissprot:DYR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DYR_ECOLI ## Database ID URL or Descriptions # BioGrid 4262650 13 # CDD cd01392 HTH_LacI # EcoGene EG10200 cytR # FUNCTION CYTR_ECOLI This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000976 transcription regulatory region sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.260.40 -; 1. # INTERACTION CYTR_ECOLI P69797 manX; NbExp=2; IntAct=EBI-1125696, EBI-554089; # IntAct P0ACN7 6 # InterPro IPR000843 HTH_LacI # InterPro IPR010982 Lambda_DNA-bd_dom # InterPro IPR028082 Peripla_BP_I # KEGG_Brite ko03000 Transcription factors # Organism CYTR_ECOLI Escherichia coli (strain K12) # PATRIC 32123383 VBIEscCol129921_4052 # PDB 2LCV NMR; -; A=1-67 # PIR A24963 RPECCT # PROSITE PS00356 HTH_LACI_1 # PROSITE PS50932 HTH_LACI_2 # Pfam PF00356 LacI # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CYTR_ECOLI HTH-type transcriptional repressor CytR # RefSeq NP_418369 NC_000913.3 # RefSeq WP_000644904 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lacI-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00111}. # SMART SM00354 HTH_LACI # SUPFAM SSF47413 SSF47413 # SUPFAM SSF53822 SSF53822 # eggNOG COG1609 LUCA # eggNOG ENOG4105ETE Bacteria BLAST swissprot:CYTR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CYTR_ECOLI BioCyc ECOL316407:JW3905-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3905-MONOMER BioCyc EcoCyc:PD04028 http://biocyc.org/getid?id=EcoCyc:PD04028 COG COG1609 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1609 DIP DIP-9390N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9390N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.87.12.4620 http://dx.doi.org/10.1073/pnas.87.12.4620 DOI 10.1093/nar/14.5.2215 http://dx.doi.org/10.1093/nar/14.5.2215 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL M33293 http://www.ebi.ac.uk/ena/data/view/M33293 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X03683 http://www.ebi.ac.uk/ena/data/view/X03683 EchoBASE EB0196 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0196 EcoGene EG10200 http://www.ecogene.org/geneInfo.php?eg_id=EG10200 EnsemblBacteria AAC76916 http://www.ensemblgenomes.org/id/AAC76916 EnsemblBacteria AAC76916 http://www.ensemblgenomes.org/id/AAC76916 EnsemblBacteria BAE77376 http://www.ensemblgenomes.org/id/BAE77376 EnsemblBacteria BAE77376 http://www.ensemblgenomes.org/id/BAE77376 EnsemblBacteria BAE77376 http://www.ensemblgenomes.org/id/BAE77376 EnsemblBacteria b3934 http://www.ensemblgenomes.org/id/b3934 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000976 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000976 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.260.40 http://www.cathdb.info/version/latest/superfamily/1.10.260.40 GeneID 948427 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948427 HOGENOM HOG000220180 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220180&db=HOGENOM6 InParanoid P0ACN7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACN7 IntAct P0ACN7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACN7* InterPro IPR000843 http://www.ebi.ac.uk/interpro/entry/IPR000843 InterPro IPR010982 http://www.ebi.ac.uk/interpro/entry/IPR010982 InterPro IPR028082 http://www.ebi.ac.uk/interpro/entry/IPR028082 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW3905 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3905 KEGG_Gene eco:b3934 http://www.genome.jp/dbget-bin/www_bget?eco:b3934 KEGG_Orthology KO:K05499 http://www.genome.jp/dbget-bin/www_bget?KO:K05499 OMA PRYDIGR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PRYDIGR PDB 2LCV http://www.ebi.ac.uk/pdbe-srv/view/entry/2LCV PDBsum 2LCV http://www.ebi.ac.uk/pdbsum/2LCV PROSITE PS00356 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00356 PROSITE PS50932 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50932 PSORT swissprot:CYTR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CYTR_ECOLI PSORT-B swissprot:CYTR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CYTR_ECOLI PSORT2 swissprot:CYTR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CYTR_ECOLI Pfam PF00356 http://pfam.xfam.org/family/PF00356 Phobius swissprot:CYTR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CYTR_ECOLI PhylomeDB P0ACN7 http://phylomedb.org/?seqid=P0ACN7 ProteinModelPortal P0ACN7 http://www.proteinmodelportal.org/query/uniprot/P0ACN7 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2162050 http://www.ncbi.nlm.nih.gov/pubmed/2162050 PubMed 3515317 http://www.ncbi.nlm.nih.gov/pubmed/3515317 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418369 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418369 RefSeq WP_000644904 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000644904 SMART SM00354 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00354 SMR P0ACN7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACN7 STRING 511145.b3934 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3934&targetmode=cogs STRING COG1609 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1609&targetmode=cogs SUPFAM SSF47413 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47413 SUPFAM SSF53822 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822 UniProtKB CYTR_ECOLI http://www.uniprot.org/uniprot/CYTR_ECOLI UniProtKB-AC P0ACN7 http://www.uniprot.org/uniprot/P0ACN7 charge swissprot:CYTR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CYTR_ECOLI eggNOG COG1609 http://eggnogapi.embl.de/nog_data/html/tree/COG1609 eggNOG ENOG4105ETE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ETE epestfind swissprot:CYTR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CYTR_ECOLI garnier swissprot:CYTR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CYTR_ECOLI helixturnhelix swissprot:CYTR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CYTR_ECOLI hmoment swissprot:CYTR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CYTR_ECOLI iep swissprot:CYTR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CYTR_ECOLI inforesidue swissprot:CYTR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CYTR_ECOLI octanol swissprot:CYTR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CYTR_ECOLI pepcoil swissprot:CYTR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CYTR_ECOLI pepdigest swissprot:CYTR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CYTR_ECOLI pepinfo swissprot:CYTR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CYTR_ECOLI pepnet swissprot:CYTR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CYTR_ECOLI pepstats swissprot:CYTR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CYTR_ECOLI pepwheel swissprot:CYTR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CYTR_ECOLI pepwindow swissprot:CYTR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CYTR_ECOLI sigcleave swissprot:CYTR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CYTR_ECOLI ## Database ID URL or Descriptions # BioGrid 4261125 10 # EcoGene EG13081 ygdI # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GOslim_component GO:0005886 plasma membrane # IntAct P65292 2 # InterPro IPR010305 DUF903 # InterPro IPR010920 LSM_dom # Organism YGDI_ECOLI Escherichia coli (strain K12) # PATRIC 32121034 VBIEscCol129921_2909 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF06004 DUF903 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGDI_ECOLI Uncharacterized lipoprotein YgdI # RefSeq NP_417289 NC_000913.3 # RefSeq WP_000750398 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40459.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY To E.coli YgdR. {ECO 0000305}. # SUBCELLULAR LOCATION YGDI_ECOLI Cell membrane {ECO 0000255|PROSITE- ProRule PRU00303}; Lipid-anchor {ECO 0000255|PROSITE- ProRule PRU00303}. # SUPFAM SSF50182 SSF50182 # eggNOG ENOG4105M5B Bacteria # eggNOG ENOG4111UW1 LUCA BLAST swissprot:YGDI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGDI_ECOLI BioCyc ECOL316407:JW5448-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5448-MONOMER BioCyc EcoCyc:G7453-MONOMER http://biocyc.org/getid?id=EcoCyc:G7453-MONOMER DIP DIP-48041N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48041N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 EchoBASE EB2890 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2890 EcoGene EG13081 http://www.ecogene.org/geneInfo.php?eg_id=EG13081 EnsemblBacteria AAC75851 http://www.ensemblgenomes.org/id/AAC75851 EnsemblBacteria AAC75851 http://www.ensemblgenomes.org/id/AAC75851 EnsemblBacteria BAE76881 http://www.ensemblgenomes.org/id/BAE76881 EnsemblBacteria BAE76881 http://www.ensemblgenomes.org/id/BAE76881 EnsemblBacteria BAE76881 http://www.ensemblgenomes.org/id/BAE76881 EnsemblBacteria b2809 http://www.ensemblgenomes.org/id/b2809 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 947276 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947276 HOGENOM HOG000282509 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000282509&db=HOGENOM6 IntAct P65292 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P65292* InterPro IPR010305 http://www.ebi.ac.uk/interpro/entry/IPR010305 InterPro IPR010920 http://www.ebi.ac.uk/interpro/entry/IPR010920 KEGG_Gene ecj:JW5448 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5448 KEGG_Gene eco:b2809 http://www.genome.jp/dbget-bin/www_bget?eco:b2809 OMA GNQQQIN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GNQQQIN PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YGDI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGDI_ECOLI PSORT-B swissprot:YGDI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGDI_ECOLI PSORT2 swissprot:YGDI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGDI_ECOLI Pfam PF06004 http://pfam.xfam.org/family/PF06004 Phobius swissprot:YGDI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGDI_ECOLI ProteinModelPortal P65292 http://www.proteinmodelportal.org/query/uniprot/P65292 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417289 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417289 RefSeq WP_000750398 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000750398 SMR P65292 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P65292 STRING 511145.b2809 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2809&targetmode=cogs SUPFAM SSF50182 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50182 UniProtKB YGDI_ECOLI http://www.uniprot.org/uniprot/YGDI_ECOLI UniProtKB-AC P65292 http://www.uniprot.org/uniprot/P65292 charge swissprot:YGDI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGDI_ECOLI eggNOG ENOG4105M5B http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105M5B eggNOG ENOG4111UW1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111UW1 epestfind swissprot:YGDI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGDI_ECOLI garnier swissprot:YGDI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGDI_ECOLI helixturnhelix swissprot:YGDI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGDI_ECOLI hmoment swissprot:YGDI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGDI_ECOLI iep swissprot:YGDI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGDI_ECOLI inforesidue swissprot:YGDI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGDI_ECOLI octanol swissprot:YGDI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGDI_ECOLI pepcoil swissprot:YGDI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGDI_ECOLI pepdigest swissprot:YGDI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGDI_ECOLI pepinfo swissprot:YGDI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGDI_ECOLI pepnet swissprot:YGDI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGDI_ECOLI pepstats swissprot:YGDI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGDI_ECOLI pepwheel swissprot:YGDI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGDI_ECOLI pepwindow swissprot:YGDI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGDI_ECOLI sigcleave swissprot:YGDI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGDI_ECOLI ## Database ID URL or Descriptions # BioGrid 4262643 11 # EcoGene EG11870 yiiM # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003824 catalytic activity; IEA:InterPro. # GO_function GO:0030151 molybdenum ion binding; IEA:InterPro. # GO_function GO:0030170 pyridoxal phosphate binding; IEA:InterPro. # GO_process GO:0009636 response to toxic substance; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # Gene3D 2.40.33.20 -; 1. # IntAct P32157 3 # InterPro IPR005163 3-alpha_domain # InterPro IPR005302 MoCF_Sase_C # InterPro IPR011037 Pyrv_Knase-like_insert_dom # InterPro IPR015808 MoCF_Sase_C-like # Organism YIIM_ECOLI Escherichia coli (strain K12) # PATRIC 32123333 VBIEscCol129921_4027 # PDB 1O65 X-ray; 2.33 A; A/B/C=1-224 # PDB 1O67 X-ray; 2.54 A; A/B/C=1-224 # PIR S40854 S40854 # PROSITE PS51340 MOSC # Pfam PF03473 MOSC # Pfam PF03475 3-alpha # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIIM_ECOLI Protein YiiM # RefSeq NP_418346 NC_000913.3 # RefSeq WP_001270260 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB03043.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Contains 1 MOSC domain. {ECO:0000255|PROSITE- ProRule PRU00670}. # SUBUNIT Monomer. {ECO:0000269|PubMed 16021622}. # SUPFAM SSF50800 SSF50800 # eggNOG COG2258 LUCA # eggNOG ENOG4108RPX Bacteria BLAST swissprot:YIIM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIIM_ECOLI BioCyc ECOL316407:JW5559-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5559-MONOMER BioCyc EcoCyc:EG11870-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11870-MONOMER DIP DIP-12512N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12512N DOI 10.1002/prot.20541 http://dx.doi.org/10.1002/prot.20541 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1816 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1816 EcoGene EG11870 http://www.ecogene.org/geneInfo.php?eg_id=EG11870 EnsemblBacteria AAC76892 http://www.ensemblgenomes.org/id/AAC76892 EnsemblBacteria AAC76892 http://www.ensemblgenomes.org/id/AAC76892 EnsemblBacteria BAE77399 http://www.ensemblgenomes.org/id/BAE77399 EnsemblBacteria BAE77399 http://www.ensemblgenomes.org/id/BAE77399 EnsemblBacteria BAE77399 http://www.ensemblgenomes.org/id/BAE77399 EnsemblBacteria b3910 http://www.ensemblgenomes.org/id/b3910 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003824 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003824 GO_function GO:0030151 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030151 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_process GO:0009636 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009636 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 2.40.33.20 http://www.cathdb.info/version/latest/superfamily/2.40.33.20 GeneID 948406 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948406 HOGENOM HOG000051122 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000051122&db=HOGENOM6 InParanoid P32157 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32157 IntAct P32157 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32157* InterPro IPR005163 http://www.ebi.ac.uk/interpro/entry/IPR005163 InterPro IPR005302 http://www.ebi.ac.uk/interpro/entry/IPR005302 InterPro IPR011037 http://www.ebi.ac.uk/interpro/entry/IPR011037 InterPro IPR015808 http://www.ebi.ac.uk/interpro/entry/IPR015808 KEGG_Gene ecj:JW5559 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5559 KEGG_Gene eco:b3910 http://www.genome.jp/dbget-bin/www_bget?eco:b3910 OMA HMPFDDE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HMPFDDE PDB 1O65 http://www.ebi.ac.uk/pdbe-srv/view/entry/1O65 PDB 1O67 http://www.ebi.ac.uk/pdbe-srv/view/entry/1O67 PDBsum 1O65 http://www.ebi.ac.uk/pdbsum/1O65 PDBsum 1O67 http://www.ebi.ac.uk/pdbsum/1O67 PROSITE PS51340 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51340 PSORT swissprot:YIIM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIIM_ECOLI PSORT-B swissprot:YIIM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIIM_ECOLI PSORT2 swissprot:YIIM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIIM_ECOLI Pfam PF03473 http://pfam.xfam.org/family/PF03473 Pfam PF03475 http://pfam.xfam.org/family/PF03475 Phobius swissprot:YIIM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIIM_ECOLI PhylomeDB P32157 http://phylomedb.org/?seqid=P32157 ProteinModelPortal P32157 http://www.proteinmodelportal.org/query/uniprot/P32157 PubMed 16021622 http://www.ncbi.nlm.nih.gov/pubmed/16021622 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418346 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418346 RefSeq WP_001270260 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001270260 SMR P32157 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32157 STRING 511145.b3910 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3910&targetmode=cogs SUPFAM SSF50800 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50800 UniProtKB YIIM_ECOLI http://www.uniprot.org/uniprot/YIIM_ECOLI UniProtKB-AC P32157 http://www.uniprot.org/uniprot/P32157 charge swissprot:YIIM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIIM_ECOLI eggNOG COG2258 http://eggnogapi.embl.de/nog_data/html/tree/COG2258 eggNOG ENOG4108RPX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108RPX epestfind swissprot:YIIM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIIM_ECOLI garnier swissprot:YIIM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIIM_ECOLI helixturnhelix swissprot:YIIM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIIM_ECOLI hmoment swissprot:YIIM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIIM_ECOLI iep swissprot:YIIM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIIM_ECOLI inforesidue swissprot:YIIM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIIM_ECOLI octanol swissprot:YIIM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIIM_ECOLI pepcoil swissprot:YIIM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIIM_ECOLI pepdigest swissprot:YIIM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIIM_ECOLI pepinfo swissprot:YIIM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIIM_ECOLI pepnet swissprot:YIIM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIIM_ECOLI pepstats swissprot:YIIM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIIM_ECOLI pepwheel swissprot:YIIM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIIM_ECOLI pepwindow swissprot:YIIM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIIM_ECOLI sigcleave swissprot:YIIM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIIM_ECOLI ## Database ID URL or Descriptions # AltName CYSC_ECOLI APS kinase # AltName CYSC_ECOLI ATP adenosine-5'-phosphosulfate 3'-phosphotransferase # AltName CYSC_ECOLI Adenosine-5'-phosphosulfate kinase # BioGrid 4263423 16 # CATALYTIC ACTIVITY CYSC_ECOLI ATP + adenylyl sulfate = ADP + 3'- phosphoadenylyl sulfate. # CDD cd02027 APSK # EcoGene EG10185 cysC # FUNCTION CYSC_ECOLI Catalyzes the synthesis of activated sulfate. # GO_function GO:0004020 adenylylsulfate kinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0000103 sulfate assimilation; IEA:UniProtKB-HAMAP. # GO_process GO:0016310 phosphorylation; IMP:EcoCyc. # GO_process GO:0070814 hydrogen sulfide biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.300 -; 1. # HAMAP MF_00065 Adenylyl_sulf_kinase # IntAct P0A6J1 11 # InterPro IPR002891 APS_kinase # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00920 Sulfur metabolism # Organism CYSC_ECOLI Escherichia coli (strain K12) # PATHWAY Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate step 2/3. # PATRIC 32120906 VBIEscCol129921_2845 # PIR B65056 B65056 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CYSC_ECOLI Adenylyl-sulfate kinase # RefSeq NP_417230 NC_000913.3 # RefSeq WP_001173673 NZ_LN832404.1 # SIMILARITY Belongs to the APS kinase family. {ECO 0000305}. # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR00455 apsK # UniPathway UPA00140 UER00205 # eggNOG COG0529 LUCA # eggNOG ENOG4107UCJ Bacteria BLAST swissprot:CYSC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CYSC_ECOLI BioCyc ECOL316407:JW2720-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2720-MONOMER BioCyc EcoCyc:ADENYLYLSULFKIN-MONOMER http://biocyc.org/getid?id=EcoCyc:ADENYLYLSULFKIN-MONOMER BioCyc MetaCyc:ADENYLYLSULFKIN-MONOMER http://biocyc.org/getid?id=MetaCyc:ADENYLYLSULFKIN-MONOMER COG COG0529 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0529 DOI 10.1021/bi00162a003 http://dx.doi.org/10.1021/bi00162a003 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.25 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.25 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M74586 http://www.ebi.ac.uk/ena/data/view/M74586 EMBL M86936 http://www.ebi.ac.uk/ena/data/view/M86936 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 ENZYME 2.7.1.25 http://enzyme.expasy.org/EC/2.7.1.25 EchoBASE EB0182 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0182 EcoGene EG10185 http://www.ecogene.org/geneInfo.php?eg_id=EG10185 EnsemblBacteria AAC75792 http://www.ensemblgenomes.org/id/AAC75792 EnsemblBacteria AAC75792 http://www.ensemblgenomes.org/id/AAC75792 EnsemblBacteria BAE76827 http://www.ensemblgenomes.org/id/BAE76827 EnsemblBacteria BAE76827 http://www.ensemblgenomes.org/id/BAE76827 EnsemblBacteria BAE76827 http://www.ensemblgenomes.org/id/BAE76827 EnsemblBacteria b2750 http://www.ensemblgenomes.org/id/b2750 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004020 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0000103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000103 GO_process GO:0016310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016310 GO_process GO:0070814 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070814 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947221 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947221 HAMAP MF_00065 http://hamap.expasy.org/unirule/MF_00065 HOGENOM HOG000228204 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000228204&db=HOGENOM6 InParanoid P0A6J1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6J1 IntAct P0A6J1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6J1* IntEnz 2.7.1.25 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.25 InterPro IPR002891 http://www.ebi.ac.uk/interpro/entry/IPR002891 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2720 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2720 KEGG_Gene eco:b2750 http://www.genome.jp/dbget-bin/www_bget?eco:b2750 KEGG_Orthology KO:K00860 http://www.genome.jp/dbget-bin/www_bget?KO:K00860 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00920 http://www.genome.jp/kegg-bin/show_pathway?ko00920 KEGG_Reaction rn:R00509 http://www.genome.jp/dbget-bin/www_bget?rn:R00509 KEGG_Reaction rn:R04928 http://www.genome.jp/dbget-bin/www_bget?rn:R04928 OMA NIKWHNL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NIKWHNL PSORT swissprot:CYSC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CYSC_ECOLI PSORT-B swissprot:CYSC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CYSC_ECOLI PSORT2 swissprot:CYSC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CYSC_ECOLI Phobius swissprot:CYSC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CYSC_ECOLI PhylomeDB P0A6J1 http://phylomedb.org/?seqid=P0A6J1 ProteinModelPortal P0A6J1 http://www.proteinmodelportal.org/query/uniprot/P0A6J1 PubMed 1316900 http://www.ncbi.nlm.nih.gov/pubmed/1316900 PubMed 1332767 http://www.ncbi.nlm.nih.gov/pubmed/1332767 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2828368 http://www.ncbi.nlm.nih.gov/pubmed/2828368 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417230 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417230 RefSeq WP_001173673 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001173673 SMR P0A6J1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6J1 STRING 511145.b2750 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2750&targetmode=cogs STRING COG0529 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0529&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR00455 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00455 UniProtKB CYSC_ECOLI http://www.uniprot.org/uniprot/CYSC_ECOLI UniProtKB-AC P0A6J1 http://www.uniprot.org/uniprot/P0A6J1 charge swissprot:CYSC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CYSC_ECOLI eggNOG COG0529 http://eggnogapi.embl.de/nog_data/html/tree/COG0529 eggNOG ENOG4107UCJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107UCJ epestfind swissprot:CYSC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CYSC_ECOLI garnier swissprot:CYSC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CYSC_ECOLI helixturnhelix swissprot:CYSC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CYSC_ECOLI hmoment swissprot:CYSC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CYSC_ECOLI iep swissprot:CYSC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CYSC_ECOLI inforesidue swissprot:CYSC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CYSC_ECOLI octanol swissprot:CYSC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CYSC_ECOLI pepcoil swissprot:CYSC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CYSC_ECOLI pepdigest swissprot:CYSC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CYSC_ECOLI pepinfo swissprot:CYSC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CYSC_ECOLI pepnet swissprot:CYSC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CYSC_ECOLI pepstats swissprot:CYSC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CYSC_ECOLI pepwheel swissprot:CYSC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CYSC_ECOLI pepwindow swissprot:CYSC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CYSC_ECOLI sigcleave swissprot:CYSC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CYSC_ECOLI ## Database ID URL or Descriptions # BioGrid 4259562 208 # DISRUPTION PHENOTYPE Deletion increases biofilm formation after 8 hours and decreases biofilm formation after 24 hours. {ECO:0000269|PubMed 19060153}. # EcoGene EG12530 tabA # FUNCTION TABA_ECOLI Influences biofilm formation. Represses fimbria genes in 8 hours biofilms. May act in response to the combined activity of several toxin-antitoxin (TA) systems. {ECO 0000269|PubMed 19060153}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_process GO:0044010 single-species biofilm formation; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_process GO:0008150 biological_process # Gene3D 2.60.120.370 -; 1. # INDUCTION Induced by simultaneous deletion of five TA systems (MazF/MazE, RelE/RelB, ChpB, YoeB/YefM, and YafQ/DinJ). {ECO:0000269|PubMed 19060153}. # InterPro IPR004375 YhcH/YjgK/YiaL # Organism TABA_ECOLI Escherichia coli (strain K12) # PATRIC 32124075 VBIEscCol129921_4382 # PIR S56477 S56477 # Pfam PF04074 DUF386 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TABA_ECOLI Toxin-antitoxin biofilm protein TabA # RefSeq NP_418673 NC_000913.3 # RefSeq WP_000583469 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97148.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the TabA/YhcH/YiaL family. {ECO 0000305}. # TIGRFAMs TIGR00022 TIGR00022 # eggNOG COG2731 LUCA # eggNOG ENOG4105XEP Bacteria BLAST swissprot:TABA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TABA_ECOLI BioCyc ECOL316407:JW5756-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5756-MONOMER BioCyc EcoCyc:G7883-MONOMER http://biocyc.org/getid?id=EcoCyc:G7883-MONOMER DIP DIP-48214N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48214N DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01465-08 http://dx.doi.org/10.1128/JB.01465-08 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2420 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2420 EcoGene EG12530 http://www.ecogene.org/geneInfo.php?eg_id=EG12530 EnsemblBacteria AAC77209 http://www.ensemblgenomes.org/id/AAC77209 EnsemblBacteria AAC77209 http://www.ensemblgenomes.org/id/AAC77209 EnsemblBacteria BAE78249 http://www.ensemblgenomes.org/id/BAE78249 EnsemblBacteria BAE78249 http://www.ensemblgenomes.org/id/BAE78249 EnsemblBacteria BAE78249 http://www.ensemblgenomes.org/id/BAE78249 EnsemblBacteria b4252 http://www.ensemblgenomes.org/id/b4252 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_process GO:0044010 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044010 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 2.60.120.370 http://www.cathdb.info/version/latest/superfamily/2.60.120.370 GeneID 948777 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948777 HOGENOM HOG000282947 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000282947&db=HOGENOM6 InParanoid P0AF96 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AF96 InterPro IPR004375 http://www.ebi.ac.uk/interpro/entry/IPR004375 KEGG_Gene ecj:JW5756 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5756 KEGG_Gene eco:b4252 http://www.genome.jp/dbget-bin/www_bget?eco:b4252 OMA EYVKQHI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EYVKQHI PSORT swissprot:TABA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TABA_ECOLI PSORT-B swissprot:TABA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TABA_ECOLI PSORT2 swissprot:TABA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TABA_ECOLI Pfam PF04074 http://pfam.xfam.org/family/PF04074 Phobius swissprot:TABA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TABA_ECOLI PhylomeDB P0AF96 http://phylomedb.org/?seqid=P0AF96 ProteinModelPortal P0AF96 http://www.proteinmodelportal.org/query/uniprot/P0AF96 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 19060153 http://www.ncbi.nlm.nih.gov/pubmed/19060153 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418673 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418673 RefSeq WP_000583469 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000583469 SMR P0AF96 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AF96 STRING 511145.b4252 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4252&targetmode=cogs TIGRFAMs TIGR00022 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00022 UniProtKB TABA_ECOLI http://www.uniprot.org/uniprot/TABA_ECOLI UniProtKB-AC P0AF96 http://www.uniprot.org/uniprot/P0AF96 charge swissprot:TABA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TABA_ECOLI eggNOG COG2731 http://eggnogapi.embl.de/nog_data/html/tree/COG2731 eggNOG ENOG4105XEP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105XEP epestfind swissprot:TABA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TABA_ECOLI garnier swissprot:TABA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TABA_ECOLI helixturnhelix swissprot:TABA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TABA_ECOLI hmoment swissprot:TABA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TABA_ECOLI iep swissprot:TABA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TABA_ECOLI inforesidue swissprot:TABA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TABA_ECOLI octanol swissprot:TABA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TABA_ECOLI pepcoil swissprot:TABA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TABA_ECOLI pepdigest swissprot:TABA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TABA_ECOLI pepinfo swissprot:TABA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TABA_ECOLI pepnet swissprot:TABA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TABA_ECOLI pepstats swissprot:TABA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TABA_ECOLI pepwheel swissprot:TABA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TABA_ECOLI pepwindow swissprot:TABA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TABA_ECOLI sigcleave swissprot:TABA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TABA_ECOLI ## Database ID URL or Descriptions # AltName PTFC2_ECOLI PTS system fructose-like EIIC component 2 # BioGrid 4262060 5 # DOMAIN PTFC2_ECOLI The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site. # EcoGene EG11908 frwC # FUNCTION PTFC2_ECOLI The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. {ECO 0000250}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; ISM:EcoCyc. # GO_function GO:0008982 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:InterPro. # GO_function PTFC2_ECOLI GO 0005351 sugar proton symporter activity; IEA InterPro. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR006327 PTS_IIC_fruc # InterPro IPR013014 PTS_EIIC_2 # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00306 PTS system, fructose-specific II-like component # KEGG_Brite ko02000 Transporters # Organism PTFC2_ECOLI Escherichia coli (strain K12) # PATRIC 32123419 VBIEscCol129921_4070 # PIR H65201 H65201 # PROSITE PS51104 PTS_EIIC_TYPE_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PTFC2_ECOLI Fructose-like permease IIC component 2 # RefSeq NP_418384 NC_000913.3 # RefSeq WP_001004446 NZ_LN832404.1 # SIMILARITY Contains 1 PTS EIIC type-2 domain. {ECO:0000255|PROSITE-ProRule PRU00427}. # SUBCELLULAR LOCATION PTFC2_ECOLI Cell inner membrane {ECO 0000255|PROSITE- ProRule PRU00427, ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00427, ECO 0000269|PubMed 15919996}. # TCDB 4.A.2.1.10 the pts fructose-mannitol (fru) family # TIGRFAMs TIGR01427 PTS_IIC_fructo # eggNOG COG1299 LUCA # eggNOG ENOG4105DM4 Bacteria BLAST swissprot:PTFC2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTFC2_ECOLI BioCyc ECOL316407:JW3921-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3921-MONOMER BioCyc EcoCyc:FRWC-MONOMER http://biocyc.org/getid?id=EcoCyc:FRWC-MONOMER BioCyc MetaCyc:FRWC-MONOMER http://biocyc.org/getid?id=MetaCyc:FRWC-MONOMER COG COG1299 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1299 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1099/13500872-141-4-961 http://dx.doi.org/10.1099/13500872-141-4-961 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1852 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1852 EcoGene EG11908 http://www.ecogene.org/geneInfo.php?eg_id=EG11908 EnsemblBacteria AAC76931 http://www.ensemblgenomes.org/id/AAC76931 EnsemblBacteria AAC76931 http://www.ensemblgenomes.org/id/AAC76931 EnsemblBacteria BAE77362 http://www.ensemblgenomes.org/id/BAE77362 EnsemblBacteria BAE77362 http://www.ensemblgenomes.org/id/BAE77362 EnsemblBacteria BAE77362 http://www.ensemblgenomes.org/id/BAE77362 EnsemblBacteria b3949 http://www.ensemblgenomes.org/id/b3949 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0005351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005351 GO_function GO:0008982 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008982 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948448 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948448 HOGENOM HOG000227677 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000227677&db=HOGENOM6 InterPro IPR006327 http://www.ebi.ac.uk/interpro/entry/IPR006327 InterPro IPR013014 http://www.ebi.ac.uk/interpro/entry/IPR013014 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3921 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3921 KEGG_Gene eco:b3949 http://www.genome.jp/dbget-bin/www_bget?eco:b3949 KEGG_Orthology KO:K11203 http://www.genome.jp/dbget-bin/www_bget?KO:K11203 OMA IQNRITD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IQNRITD PROSITE PS51104 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51104 PSORT swissprot:PTFC2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTFC2_ECOLI PSORT-B swissprot:PTFC2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTFC2_ECOLI PSORT2 swissprot:PTFC2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTFC2_ECOLI Phobius swissprot:PTFC2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTFC2_ECOLI PhylomeDB P32672 http://phylomedb.org/?seqid=P32672 ProteinModelPortal P32672 http://www.proteinmodelportal.org/query/uniprot/P32672 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7773398 http://www.ncbi.nlm.nih.gov/pubmed/7773398 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418384 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418384 RefSeq WP_001004446 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001004446 STRING 511145.b3949 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3949&targetmode=cogs STRING COG1299 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1299&targetmode=cogs TCDB 4.A.2.1.10 http://www.tcdb.org/search/result.php?tc=4.A.2.1.10 TIGRFAMs TIGR01427 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01427 UniProtKB PTFC2_ECOLI http://www.uniprot.org/uniprot/PTFC2_ECOLI UniProtKB-AC P32672 http://www.uniprot.org/uniprot/P32672 charge swissprot:PTFC2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTFC2_ECOLI eggNOG COG1299 http://eggnogapi.embl.de/nog_data/html/tree/COG1299 eggNOG ENOG4105DM4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DM4 epestfind swissprot:PTFC2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTFC2_ECOLI garnier swissprot:PTFC2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTFC2_ECOLI helixturnhelix swissprot:PTFC2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTFC2_ECOLI hmoment swissprot:PTFC2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTFC2_ECOLI iep swissprot:PTFC2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTFC2_ECOLI inforesidue swissprot:PTFC2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTFC2_ECOLI octanol swissprot:PTFC2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTFC2_ECOLI pepcoil swissprot:PTFC2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTFC2_ECOLI pepdigest swissprot:PTFC2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTFC2_ECOLI pepinfo swissprot:PTFC2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTFC2_ECOLI pepnet swissprot:PTFC2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTFC2_ECOLI pepstats swissprot:PTFC2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTFC2_ECOLI pepwheel swissprot:PTFC2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTFC2_ECOLI pepwindow swissprot:PTFC2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTFC2_ECOLI sigcleave swissprot:PTFC2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTFC2_ECOLI ## Database ID URL or Descriptions # AltName EBGR_ECOLI Ebg operon repressor # BioGrid 4260843 14 # CDD cd01392 HTH_LacI # EcoGene EG10254 ebgR # FUNCTION EBGR_ECOLI Repressor for beta galactosidase alpha and beta subunits (ebgA and ebgC). Binds lactose as an inducer. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IMP:EcoCyc. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.260.40 -; 1. # InterPro IPR000843 HTH_LacI # InterPro IPR010982 Lambda_DNA-bd_dom # InterPro IPR028082 Peripla_BP_I # KEGG_Brite ko03000 Transcription factors # Organism EBGR_ECOLI Escherichia coli (strain K12) # PATRIC 32121566 VBIEscCol129921_3169 # PIR A25752 RPECEG # PRINTS PR00036 HTHLACI # PROSITE PS00356 HTH_LACI_1 # PROSITE PS50932 HTH_LACI_2 # Pfam PF00356 LacI # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EBGR_ECOLI HTH-type transcriptional regulator EbgR # RefSeq NP_417546 NC_000913.3 # RefSeq WP_000212475 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lacI-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00111}. # SMART SM00354 HTH_LACI # SUPFAM SSF47413 SSF47413 # SUPFAM SSF53822 SSF53822 # eggNOG COG1609 LUCA # eggNOG ENOG4105CQ4 Bacteria BLAST swissprot:EBGR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EBGR_ECOLI BioCyc ECOL316407:JW3046-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3046-MONOMER BioCyc EcoCyc:PD03254 http://biocyc.org/getid?id=EcoCyc:PD03254 COG COG1609 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1609 DIP DIP-9488N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9488N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M64441 http://www.ebi.ac.uk/ena/data/view/M64441 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X52031 http://www.ebi.ac.uk/ena/data/view/X52031 EchoBASE EB0250 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0250 EcoGene EG10254 http://www.ecogene.org/geneInfo.php?eg_id=EG10254 EnsemblBacteria AAC76110 http://www.ensemblgenomes.org/id/AAC76110 EnsemblBacteria AAC76110 http://www.ensemblgenomes.org/id/AAC76110 EnsemblBacteria BAE77125 http://www.ensemblgenomes.org/id/BAE77125 EnsemblBacteria BAE77125 http://www.ensemblgenomes.org/id/BAE77125 EnsemblBacteria BAE77125 http://www.ensemblgenomes.org/id/BAE77125 EnsemblBacteria b3075 http://www.ensemblgenomes.org/id/b3075 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.260.40 http://www.cathdb.info/version/latest/superfamily/1.10.260.40 GeneID 947586 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947586 HOGENOM HOG000220180 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220180&db=HOGENOM6 InParanoid P06846 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P06846 IntAct P06846 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P06846* InterPro IPR000843 http://www.ebi.ac.uk/interpro/entry/IPR000843 InterPro IPR010982 http://www.ebi.ac.uk/interpro/entry/IPR010982 InterPro IPR028082 http://www.ebi.ac.uk/interpro/entry/IPR028082 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW3046 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3046 KEGG_Gene eco:b3075 http://www.genome.jp/dbget-bin/www_bget?eco:b3075 KEGG_Orthology KO:K12113 http://www.genome.jp/dbget-bin/www_bget?KO:K12113 OMA KAFFIAN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KAFFIAN PRINTS PR00036 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00036 PROSITE PS00356 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00356 PROSITE PS50932 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50932 PSORT swissprot:EBGR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EBGR_ECOLI PSORT-B swissprot:EBGR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EBGR_ECOLI PSORT2 swissprot:EBGR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EBGR_ECOLI Pfam PF00356 http://pfam.xfam.org/family/PF00356 Phobius swissprot:EBGR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EBGR_ECOLI PhylomeDB P06846 http://phylomedb.org/?seqid=P06846 ProteinModelPortal P06846 http://www.proteinmodelportal.org/query/uniprot/P06846 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2515108 http://www.ncbi.nlm.nih.gov/pubmed/2515108 PubMed 3939708 http://www.ncbi.nlm.nih.gov/pubmed/3939708 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417546 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417546 RefSeq WP_000212475 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000212475 SMART SM00354 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00354 SMR P06846 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P06846 STRING 511145.b3075 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3075&targetmode=cogs STRING COG1609 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1609&targetmode=cogs SUPFAM SSF47413 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47413 SUPFAM SSF53822 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822 UniProtKB EBGR_ECOLI http://www.uniprot.org/uniprot/EBGR_ECOLI UniProtKB-AC P06846 http://www.uniprot.org/uniprot/P06846 charge swissprot:EBGR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EBGR_ECOLI eggNOG COG1609 http://eggnogapi.embl.de/nog_data/html/tree/COG1609 eggNOG ENOG4105CQ4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CQ4 epestfind swissprot:EBGR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EBGR_ECOLI garnier swissprot:EBGR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EBGR_ECOLI helixturnhelix swissprot:EBGR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EBGR_ECOLI hmoment swissprot:EBGR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EBGR_ECOLI iep swissprot:EBGR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EBGR_ECOLI inforesidue swissprot:EBGR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EBGR_ECOLI octanol swissprot:EBGR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EBGR_ECOLI pepcoil swissprot:EBGR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EBGR_ECOLI pepdigest swissprot:EBGR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EBGR_ECOLI pepinfo swissprot:EBGR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EBGR_ECOLI pepnet swissprot:EBGR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EBGR_ECOLI pepstats swissprot:EBGR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EBGR_ECOLI pepwheel swissprot:EBGR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EBGR_ECOLI pepwindow swissprot:EBGR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EBGR_ECOLI sigcleave swissprot:EBGR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EBGR_ECOLI ## Database ID URL or Descriptions # BRENDA 4.7.1 2026 # BioGrid 4263382 8 # CATALYTIC ACTIVITY Alpha-D-ribose 1-methylphosphonate 5-phosphate = alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + methane. {ECO:0000269|PubMed 22089136}. # COFACTOR PHNJ_ECOLI Name=S-adenosyl-L-methionine; Xref=ChEBI CHEBI 59789; Evidence={ECO 0000269|PubMed 22089136}; # COFACTOR PHNJ_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000269|PubMed 22089136}; Note=Binds 1 [4Fe-4S] cluster per subunit. {ECO 0000269|PubMed 22089136}; # EcoGene EG10719 phnJ # FUNCTION PHNJ_ECOLI Catalyzes the breakage of the C-P bond in alpha-D-ribose 1-methylphosphonate 5-phosphate (PRPn) forming alpha-D-ribose 1,2- cyclic phosphate 5-phosphate (PRcP). {ECO 0000269|PubMed 22089136}. # GO_function GO:0016829 lyase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IDA:EcoCyc. # GO_function GO:0098848 alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase activity; IDA:EcoCyc. # GO_process GO:0019700 organic phosphonate catabolic process; IMP:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # IntAct P16688 4 # InterPro IPR010306 PhnJ # MISCELLANEOUS PHNJ_ECOLI The sequence shown is that of strain K12. # Organism PHNJ_ECOLI Escherichia coli (strain K12) # PATRIC 32123755 VBIEscCol129921_4226 # PDB 4XB6 X-ray; 1.70 A; D/H=1-281 # PIR A65219 A65219 # PIRSF PIRSF011468 PhnJ # Pfam PF06007 PhnJ # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PHNJ_ECOLI Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P lyase # RefSeq NP_418522 NC_000913.3 # RefSeq WP_000002303 NZ_LN832404.1 # SIMILARITY Belongs to the PhnJ family. {ECO 0000305}. # SUBUNIT Forms a complex with PhnG, PhnH, PhnI and PhnK with the suggested composition PhnG(4)H(2)I(2)J(2)K. {ECO:0000269|PubMed 21705661}. # eggNOG COG3627 LUCA # eggNOG ENOG4105FT8 Bacteria BLAST swissprot:PHNJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PHNJ_ECOLI BioCyc ECOL316407:JW4059-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4059-MONOMER BioCyc EcoCyc:EG10719-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10719-MONOMER BioCyc MetaCyc:EG10719-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10719-MONOMER COG COG3627 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3627 DIP DIP-10489N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10489N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature10622 http://dx.doi.org/10.1038/nature10622 DOI 10.1073/pnas.1104922108 http://dx.doi.org/10.1073/pnas.1104922108 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.7.1.1 http://www.genome.jp/dbget-bin/www_bget?EC:4.7.1.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D90227 http://www.ebi.ac.uk/ena/data/view/D90227 EMBL J05260 http://www.ebi.ac.uk/ena/data/view/J05260 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 4.7.1.1 http://enzyme.expasy.org/EC/4.7.1.1 EchoBASE EB0713 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0713 EcoGene EG10719 http://www.ecogene.org/geneInfo.php?eg_id=EG10719 EnsemblBacteria AAC77059 http://www.ensemblgenomes.org/id/AAC77059 EnsemblBacteria AAC77059 http://www.ensemblgenomes.org/id/AAC77059 EnsemblBacteria BAE78101 http://www.ensemblgenomes.org/id/BAE78101 EnsemblBacteria BAE78101 http://www.ensemblgenomes.org/id/BAE78101 EnsemblBacteria BAE78101 http://www.ensemblgenomes.org/id/BAE78101 EnsemblBacteria b4098 http://www.ensemblgenomes.org/id/b4098 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_function GO:0098848 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098848 GO_process GO:0019700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019700 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GeneID 948606 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948606 HOGENOM HOG000147107 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000147107&db=HOGENOM6 InParanoid P16688 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P16688 IntAct P16688 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P16688* IntEnz 4.7.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.7.1.1 InterPro IPR010306 http://www.ebi.ac.uk/interpro/entry/IPR010306 KEGG_Gene ecj:JW4059 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4059 KEGG_Gene eco:b4098 http://www.genome.jp/dbget-bin/www_bget?eco:b4098 KEGG_Orthology KO:K06163 http://www.genome.jp/dbget-bin/www_bget?KO:K06163 KEGG_Reaction rn:R10204 http://www.genome.jp/dbget-bin/www_bget?rn:R10204 OMA SVIQTRH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SVIQTRH PDB 4XB6 http://www.ebi.ac.uk/pdbe-srv/view/entry/4XB6 PDBsum 4XB6 http://www.ebi.ac.uk/pdbsum/4XB6 PSORT swissprot:PHNJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PHNJ_ECOLI PSORT-B swissprot:PHNJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PHNJ_ECOLI PSORT2 swissprot:PHNJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PHNJ_ECOLI Pfam PF06007 http://pfam.xfam.org/family/PF06007 Phobius swissprot:PHNJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PHNJ_ECOLI PhylomeDB P16688 http://phylomedb.org/?seqid=P16688 ProteinModelPortal P16688 http://www.proteinmodelportal.org/query/uniprot/P16688 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1840580 http://www.ncbi.nlm.nih.gov/pubmed/1840580 PubMed 2155230 http://www.ncbi.nlm.nih.gov/pubmed/2155230 PubMed 21705661 http://www.ncbi.nlm.nih.gov/pubmed/21705661 PubMed 22089136 http://www.ncbi.nlm.nih.gov/pubmed/22089136 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418522 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418522 RefSeq WP_000002303 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000002303 SMR P16688 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P16688 STRING 511145.b4098 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4098&targetmode=cogs STRING COG3627 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3627&targetmode=cogs UniProtKB PHNJ_ECOLI http://www.uniprot.org/uniprot/PHNJ_ECOLI UniProtKB-AC P16688 http://www.uniprot.org/uniprot/P16688 charge swissprot:PHNJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PHNJ_ECOLI eggNOG COG3627 http://eggnogapi.embl.de/nog_data/html/tree/COG3627 eggNOG ENOG4105FT8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FT8 epestfind swissprot:PHNJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PHNJ_ECOLI garnier swissprot:PHNJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PHNJ_ECOLI helixturnhelix swissprot:PHNJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PHNJ_ECOLI hmoment swissprot:PHNJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PHNJ_ECOLI iep swissprot:PHNJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PHNJ_ECOLI inforesidue swissprot:PHNJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PHNJ_ECOLI octanol swissprot:PHNJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PHNJ_ECOLI pepcoil swissprot:PHNJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PHNJ_ECOLI pepdigest swissprot:PHNJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PHNJ_ECOLI pepinfo swissprot:PHNJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PHNJ_ECOLI pepnet swissprot:PHNJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PHNJ_ECOLI pepstats swissprot:PHNJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PHNJ_ECOLI pepwheel swissprot:PHNJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PHNJ_ECOLI pepwindow swissprot:PHNJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PHNJ_ECOLI sigcleave swissprot:PHNJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PHNJ_ECOLI ## Database ID URL or Descriptions # AltName PYRF_ECOLI OMP decarboxylase # CATALYTIC ACTIVITY PYRF_ECOLI Orotidine 5'-phosphate = UMP + CO(2). # EcoGene EG10809 pyrF # FUNCTION PYRF_ECOLI Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP). # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004590 orotidine-5'-phosphate decarboxylase activity; IDA:EcoCyc. # GO_function GO:0016831 carboxy-lyase activity; IDA:EcoliWiki. # GO_process GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process; IMP:EcoCyc. # GO_process GO:0015949 nucleobase-containing small molecule interconversion; IDA:EcoliWiki. # GO_process GO:0044205 'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.70 -; 1. # HAMAP MF_01200_B OMPdecase_type1_B # INTERACTION PYRF_ECOLI P0A7I7 ribA; NbExp=2; IntAct=EBI-1123202, EBI-1123314; # IntAct P08244 4 # InterPro IPR001754 OMPdeCOase_dom # InterPro IPR011060 RibuloseP-bd_barrel # InterPro IPR013785 Aldolase_TIM # InterPro IPR014732 OMPdecase # InterPro IPR018089 OMPdecase_AS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00240 Pyrimidine metabolism # Organism PYRF_ECOLI Escherichia coli (strain K12) # PATHWAY Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate step 2/2. # PATRIC 32117826 VBIEscCol129921_1333 # PDB 1EIX X-ray; 2.50 A; A/B/C/D=1-245 # PDB 1JJK X-ray; 3.00 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P=1-245 # PDB 1L2U X-ray; 2.50 A; A/B=1-245 # PIR A28440 DCECOP # PROSITE PS00156 OMPDECASE # Pfam PF00215 OMPdecase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PYRF_ECOLI Orotidine 5'-phosphate decarboxylase # RefSeq NP_415797 NC_000913.3 # RefSeq WP_000176270 NZ_LN832404.1 # SIMILARITY Belongs to the OMP decarboxylase family. Type 1 subfamily. {ECO 0000305}. # SMART SM00934 OMPdecase # SUBUNIT PYRF_ECOLI Homodimer. {ECO 0000269|PubMed 10757968, ECO 0000269|PubMed 11526316, ECO 0000269|PubMed 12054799}. # SUPFAM SSF51366 SSF51366 # TIGRFAMs TIGR01740 pyrF # UniPathway UPA00070 UER00120 # eggNOG COG0284 LUCA # eggNOG ENOG4106EG9 Bacteria BLAST swissprot:PYRF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PYRF_ECOLI BioCyc ECOL316407:JW1273-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1273-MONOMER BioCyc EcoCyc:OROTPDECARB-MONOMER http://biocyc.org/getid?id=EcoCyc:OROTPDECARB-MONOMER BioCyc MetaCyc:OROTPDECARB-MONOMER http://biocyc.org/getid?id=MetaCyc:OROTPDECARB-MONOMER COG COG0284 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0284 DOI 10.1016/0092-8674(88)90033-5 http://dx.doi.org/10.1016/0092-8674(88)90033-5 DOI 10.1016/S0022-2836(02)00200-0 http://dx.doi.org/10.1016/S0022-2836(02)00200-0 DOI 10.1021/bi992952r http://dx.doi.org/10.1021/bi992952r DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1107/S0907444901010393 http://dx.doi.org/10.1107/S0907444901010393 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.1.1.23 http://www.genome.jp/dbget-bin/www_bget?EC:4.1.1.23 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J02768 http://www.ebi.ac.uk/ena/data/view/J02768 EMBL M23250 http://www.ebi.ac.uk/ena/data/view/M23250 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 4.1.1.23 http://enzyme.expasy.org/EC/4.1.1.23 EchoBASE EB0802 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0802 EcoGene EG10809 http://www.ecogene.org/geneInfo.php?eg_id=EG10809 EnsemblBacteria AAC74363 http://www.ensemblgenomes.org/id/AAC74363 EnsemblBacteria AAC74363 http://www.ensemblgenomes.org/id/AAC74363 EnsemblBacteria BAA14835 http://www.ensemblgenomes.org/id/BAA14835 EnsemblBacteria BAA14835 http://www.ensemblgenomes.org/id/BAA14835 EnsemblBacteria BAA14835 http://www.ensemblgenomes.org/id/BAA14835 EnsemblBacteria b1281 http://www.ensemblgenomes.org/id/b1281 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004590 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004590 GO_function GO:0016831 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016831 GO_process GO:0006207 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006207 GO_process GO:0015949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015949 GO_process GO:0044205 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044205 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 947121 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947121 HAMAP MF_01200_B http://hamap.expasy.org/unirule/MF_01200_B HOGENOM HOG000226071 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000226071&db=HOGENOM6 InParanoid P08244 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P08244 IntAct P08244 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P08244* IntEnz 4.1.1.23 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.1.23 InterPro IPR001754 http://www.ebi.ac.uk/interpro/entry/IPR001754 InterPro IPR011060 http://www.ebi.ac.uk/interpro/entry/IPR011060 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR014732 http://www.ebi.ac.uk/interpro/entry/IPR014732 InterPro IPR018089 http://www.ebi.ac.uk/interpro/entry/IPR018089 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1273 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1273 KEGG_Gene eco:b1281 http://www.genome.jp/dbget-bin/www_bget?eco:b1281 KEGG_Orthology KO:K01591 http://www.genome.jp/dbget-bin/www_bget?KO:K01591 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Reaction rn:R00965 http://www.genome.jp/dbget-bin/www_bget?rn:R00965 OMA NFKIFLD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NFKIFLD PDB 1EIX http://www.ebi.ac.uk/pdbe-srv/view/entry/1EIX PDB 1JJK http://www.ebi.ac.uk/pdbe-srv/view/entry/1JJK PDB 1L2U http://www.ebi.ac.uk/pdbe-srv/view/entry/1L2U PDBsum 1EIX http://www.ebi.ac.uk/pdbsum/1EIX PDBsum 1JJK http://www.ebi.ac.uk/pdbsum/1JJK PDBsum 1L2U http://www.ebi.ac.uk/pdbsum/1L2U PROSITE PS00156 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00156 PSORT swissprot:PYRF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PYRF_ECOLI PSORT-B swissprot:PYRF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PYRF_ECOLI PSORT2 swissprot:PYRF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PYRF_ECOLI Pfam PF00215 http://pfam.xfam.org/family/PF00215 Phobius swissprot:PYRF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PYRF_ECOLI PhylomeDB P08244 http://phylomedb.org/?seqid=P08244 ProteinModelPortal P08244 http://www.proteinmodelportal.org/query/uniprot/P08244 PubMed 10757968 http://www.ncbi.nlm.nih.gov/pubmed/10757968 PubMed 11526316 http://www.ncbi.nlm.nih.gov/pubmed/11526316 PubMed 12054799 http://www.ncbi.nlm.nih.gov/pubmed/12054799 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2956254 http://www.ncbi.nlm.nih.gov/pubmed/2956254 PubMed 3052852 http://www.ncbi.nlm.nih.gov/pubmed/3052852 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415797 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415797 RefSeq WP_000176270 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000176270 SMART SM00934 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00934 SMR P08244 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P08244 STRING 511145.b1281 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1281&targetmode=cogs STRING COG0284 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0284&targetmode=cogs SUPFAM SSF51366 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51366 SWISS-2DPAGE P08244 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P08244 TIGRFAMs TIGR01740 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01740 UniProtKB PYRF_ECOLI http://www.uniprot.org/uniprot/PYRF_ECOLI UniProtKB-AC P08244 http://www.uniprot.org/uniprot/P08244 charge swissprot:PYRF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PYRF_ECOLI eggNOG COG0284 http://eggnogapi.embl.de/nog_data/html/tree/COG0284 eggNOG ENOG4106EG9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106EG9 epestfind swissprot:PYRF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PYRF_ECOLI garnier swissprot:PYRF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PYRF_ECOLI helixturnhelix swissprot:PYRF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PYRF_ECOLI hmoment swissprot:PYRF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PYRF_ECOLI iep swissprot:PYRF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PYRF_ECOLI inforesidue swissprot:PYRF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PYRF_ECOLI octanol swissprot:PYRF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PYRF_ECOLI pepcoil swissprot:PYRF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PYRF_ECOLI pepdigest swissprot:PYRF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PYRF_ECOLI pepinfo swissprot:PYRF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PYRF_ECOLI pepnet swissprot:PYRF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PYRF_ECOLI pepstats swissprot:PYRF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PYRF_ECOLI pepwheel swissprot:PYRF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PYRF_ECOLI pepwindow swissprot:PYRF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PYRF_ECOLI sigcleave swissprot:PYRF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PYRF_ECOLI ## Database ID URL or Descriptions # BRENDA 1.8.1 2026 # BioGrid 4262283 213 # CATALYTIC ACTIVITY CYSJ_ECOLI H(2)S + 3 NADP(+) + 3 H(2)O = sulfite + 3 NADPH. {ECO 0000255|HAMAP-Rule MF_01541, ECO 0000269|PubMed 10860732}. # COFACTOR CYSJ_ECOLI Name=FAD; Xref=ChEBI CHEBI 57692; Evidence={ECO 0000255|HAMAP-Rule MF_01541, ECO 0000269|PubMed 10860732}; Note=Binds 1 FAD per subunit. {ECO 0000255|HAMAP-Rule MF_01541, ECO 0000269|PubMed 10860732}; # COFACTOR CYSJ_ECOLI Name=FMN; Xref=ChEBI CHEBI 58210; Evidence={ECO 0000255|HAMAP-Rule MF_01541, ECO 0000269|PubMed 10860732}; Note=Binds 1 FMN per subunit. {ECO 0000255|HAMAP-Rule MF_01541, ECO 0000269|PubMed 10860732}; # DrugBank DB03147 Flavin adenine dinucleotide # EcoGene EG10191 cysJ # FUNCTION CYSJ_ECOLI Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. {ECO 0000255|HAMAP-Rule MF_01541}. # GO_component GO:0009337 sulfite reductase complex (NADPH); IDA:EcoCyc. # GO_function GO:0004783 sulfite reductase (NADPH) activity; IEA:UniProtKB-HAMAP. # GO_function GO:0010181 FMN binding; IDA:EcoCyc. # GO_function GO:0042602 riboflavin reductase (NADPH) activity; IDA:EcoCyc. # GO_function GO:0050660 flavin adenine dinucleotide binding; IDA:EcoCyc. # GO_process GO:0000103 sulfate assimilation; IEA:UniProtKB-HAMAP. # GO_process GO:0008652 cellular amino acid biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0019344 cysteine biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0070814 hydrogen sulfide biosynthetic process; IEA:UniProtKB-HAMAP. # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 1.20.990.10 -; 1. # Gene3D 3.40.50.360 -; 1. # HAMAP MF_01541 CysJ # INTERACTION CYSJ_ECOLI P75863 ycbX; NbExp=4; IntAct=EBI-544440, EBI-544422; # IntAct P38038 3 # InterPro IPR001094 Flavdoxin-like # InterPro IPR001433 OxRdtase_FAD/NAD-bd # InterPro IPR001709 Flavoprot_Pyr_Nucl_cyt_Rdtase # InterPro IPR003097 FAD-binding_1 # InterPro IPR008254 Flavodoxin/NO_synth # InterPro IPR010199 CysJ # InterPro IPR017927 Fd_Rdtase_FAD-bd # InterPro IPR017938 Riboflavin_synthase-like_b-brl # InterPro IPR023173 NADPH_Cyt_P450_Rdtase_dom3 # InterPro IPR029039 Flavoprotein-like_dom # InterPro IPR029758 CysJ_Proteobact # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00920 Sulfur metabolism # Organism CYSJ_ECOLI Escherichia coli (strain K12) # PATHWAY Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1. {ECO 0000255|HAMAP-Rule:MF_01541}. # PATRIC 32120940 VBIEscCol129921_2862 # PDB 1DDG X-ray; 2.01 A; A/B=226-599 # PDB 1DDI X-ray; 2.51 A; A=226-599 # PDB 1YKG NMR; -; A=53-219 # PIR H65057 H65057 # PIRSF PIRSF000207 SiR-FP_CysJ # PRINTS PR00369 FLAVODOXIN # PRINTS PR00371 FPNCR # PROSITE PS50902 FLAVODOXIN_LIKE # PROSITE PS51384 FAD_FR # Pfam PF00175 NAD_binding_1 # Pfam PF00258 Flavodoxin_1 # Pfam PF00667 FAD_binding_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Sulfite reductase [NADPH] flavoprotein alpha-component {ECO:0000255|HAMAP-Rule MF_01541} # RefSeq NP_417244 NC_000913.3 # RefSeq WP_000211913 NZ_LN832404.1 # SIMILARITY Belongs to the NADPH-dependent sulphite reductase flavoprotein subunit CysJ family. {ECO:0000255|HAMAP- Rule MF_01541}. # SIMILARITY Contains 1 FAD-binding FR-type domain. {ECO:0000255|HAMAP-Rule MF_01541}. # SIMILARITY Contains 1 flavodoxin-like domain. {ECO:0000255|HAMAP- Rule MF_01541}. # SIMILARITY In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. {ECO:0000255|HAMAP-Rule MF_01541}. # SIMILARITY In the N-terminal section; belongs to the flavodoxin family. {ECO:0000255|HAMAP-Rule MF_01541}. # SUBUNIT CYSJ_ECOLI Alpha(8)-beta(8). The alpha component is a flavoprotein, the beta component is a hemoprotein. {ECO 0000255|HAMAP- Rule MF_01541, ECO 0000269|PubMed 10984484, ECO 0000269|PubMed 15966732}. # SUPFAM SSF52218 SSF52218 # SUPFAM SSF63380 SSF63380 # TIGRFAMs TIGR01931 cysJ # UniPathway UPA00140 UER00207 # eggNOG COG0369 LUCA # eggNOG ENOG4107EER Bacteria BLAST swissprot:CYSJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CYSJ_ECOLI BioCyc ECOL316407:JW2734-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2734-MONOMER BioCyc EcoCyc:ALPHACOMP-MONOMER http://biocyc.org/getid?id=EcoCyc:ALPHACOMP-MONOMER BioCyc MetaCyc:ALPHACOMP-MONOMER http://biocyc.org/getid?id=MetaCyc:ALPHACOMP-MONOMER COG COG0369 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0369 DIP DIP-9381N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9381N DOI 10.1006/bbrc.1998.8671 http://dx.doi.org/10.1006/bbrc.1998.8671 DOI 10.1006/jmbi.2000.3748 http://dx.doi.org/10.1006/jmbi.2000.3748 DOI 10.1016/0014-5793(95)01081-O http://dx.doi.org/10.1016/0014-5793(95)01081-O DOI 10.1021/bi016008i http://dx.doi.org/10.1021/bi016008i DOI 10.1021/bi050437p http://dx.doi.org/10.1021/bi050437p DOI 10.1021/bi9623744 http://dx.doi.org/10.1021/bi9623744 DOI 10.1021/bi9728699 http://dx.doi.org/10.1021/bi9728699 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj3420465 http://dx.doi.org/10.1042/bj3420465 DOI 10.1074/jbc.270.35.20550 http://dx.doi.org/10.1074/jbc.270.35.20550 DOI 10.1074/jbc.M005619200 http://dx.doi.org/10.1074/jbc.M005619200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DisProt DP00190 http://www.disprot.org/protein.php?id=DP00190 DrugBank DB03147 http://www.drugbank.ca/drugs/DB03147 EC_number EC:1.8.1.2 {ECO:0000255|HAMAP-Rule:MF_01541, ECO:0000269|PubMed:10860732} http://www.genome.jp/dbget-bin/www_bget?EC:1.8.1.2 {ECO:0000255|HAMAP-Rule:MF_01541, ECO:0000269|PubMed:10860732} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M23008 http://www.ebi.ac.uk/ena/data/view/M23008 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 ENZYME 1.8.1.2 {ECO:0000255|HAMAP-Rule:MF_01541, ECO:0000269|PubMed:10860732} http://enzyme.expasy.org/EC/1.8.1.2 {ECO:0000255|HAMAP-Rule:MF_01541, ECO:0000269|PubMed:10860732} EchoBASE EB0188 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0188 EcoGene EG10191 http://www.ecogene.org/geneInfo.php?eg_id=EG10191 EnsemblBacteria AAC75806 http://www.ensemblgenomes.org/id/AAC75806 EnsemblBacteria AAC75806 http://www.ensemblgenomes.org/id/AAC75806 EnsemblBacteria BAE76841 http://www.ensemblgenomes.org/id/BAE76841 EnsemblBacteria BAE76841 http://www.ensemblgenomes.org/id/BAE76841 EnsemblBacteria BAE76841 http://www.ensemblgenomes.org/id/BAE76841 EnsemblBacteria b2764 http://www.ensemblgenomes.org/id/b2764 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009337 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009337 GO_function GO:0004783 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004783 GO_function GO:0010181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010181 GO_function GO:0042602 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042602 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_process GO:0000103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000103 GO_process GO:0008652 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008652 GO_process GO:0019344 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019344 GO_process GO:0070814 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070814 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 1.20.990.10 http://www.cathdb.info/version/latest/superfamily/1.20.990.10 Gene3D 3.40.50.360 http://www.cathdb.info/version/latest/superfamily/3.40.50.360 GeneID 947239 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947239 HAMAP MF_01541 http://hamap.expasy.org/unirule/MF_01541 HOGENOM HOG000282025 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000282025&db=HOGENOM6 InParanoid P38038 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P38038 IntAct P38038 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P38038* IntEnz 1.8.1.2 {ECO:0000255|HAMAP-Rule:MF_01541, ECO:0000269|PubMed:10860732} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.8.1.2 {ECO:0000255|HAMAP-Rule:MF_01541, ECO:0000269|PubMed:10860732} InterPro IPR001094 http://www.ebi.ac.uk/interpro/entry/IPR001094 InterPro IPR001433 http://www.ebi.ac.uk/interpro/entry/IPR001433 InterPro IPR001709 http://www.ebi.ac.uk/interpro/entry/IPR001709 InterPro IPR003097 http://www.ebi.ac.uk/interpro/entry/IPR003097 InterPro IPR008254 http://www.ebi.ac.uk/interpro/entry/IPR008254 InterPro IPR010199 http://www.ebi.ac.uk/interpro/entry/IPR010199 InterPro IPR017927 http://www.ebi.ac.uk/interpro/entry/IPR017927 InterPro IPR017938 http://www.ebi.ac.uk/interpro/entry/IPR017938 InterPro IPR023173 http://www.ebi.ac.uk/interpro/entry/IPR023173 InterPro IPR029039 http://www.ebi.ac.uk/interpro/entry/IPR029039 InterPro IPR029758 http://www.ebi.ac.uk/interpro/entry/IPR029758 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2734 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2734 KEGG_Gene eco:b2764 http://www.genome.jp/dbget-bin/www_bget?eco:b2764 KEGG_Orthology KO:K00380 http://www.genome.jp/dbget-bin/www_bget?KO:K00380 KEGG_Pathway ko00920 http://www.genome.jp/kegg-bin/show_pathway?ko00920 KEGG_Reaction rn:R00858 http://www.genome.jp/dbget-bin/www_bget?rn:R00858 MINT MINT-1239442 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1239442 OMA VWYENDP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VWYENDP PDB 1DDG http://www.ebi.ac.uk/pdbe-srv/view/entry/1DDG PDB 1DDI http://www.ebi.ac.uk/pdbe-srv/view/entry/1DDI PDB 1YKG http://www.ebi.ac.uk/pdbe-srv/view/entry/1YKG PDBsum 1DDG http://www.ebi.ac.uk/pdbsum/1DDG PDBsum 1DDI http://www.ebi.ac.uk/pdbsum/1DDI PDBsum 1YKG http://www.ebi.ac.uk/pdbsum/1YKG PRINTS PR00369 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00369 PRINTS PR00371 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00371 PROSITE PS50902 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50902 PROSITE PS51384 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51384 PSORT swissprot:CYSJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CYSJ_ECOLI PSORT-B swissprot:CYSJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CYSJ_ECOLI PSORT2 swissprot:CYSJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CYSJ_ECOLI Pfam PF00175 http://pfam.xfam.org/family/PF00175 Pfam PF00258 http://pfam.xfam.org/family/PF00258 Pfam PF00667 http://pfam.xfam.org/family/PF00667 Phobius swissprot:CYSJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CYSJ_ECOLI PhylomeDB P38038 http://phylomedb.org/?seqid=P38038 ProteinModelPortal P38038 http://www.proteinmodelportal.org/query/uniprot/P38038 PubMed 10455035 http://www.ncbi.nlm.nih.gov/pubmed/10455035 PubMed 10860732 http://www.ncbi.nlm.nih.gov/pubmed/10860732 PubMed 10984484 http://www.ncbi.nlm.nih.gov/pubmed/10984484 PubMed 11888295 http://www.ncbi.nlm.nih.gov/pubmed/11888295 PubMed 15966732 http://www.ncbi.nlm.nih.gov/pubmed/15966732 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2550423 http://www.ncbi.nlm.nih.gov/pubmed/2550423 PubMed 2670946 http://www.ncbi.nlm.nih.gov/pubmed/2670946 PubMed 7589518 http://www.ncbi.nlm.nih.gov/pubmed/7589518 PubMed 7657631 http://www.ncbi.nlm.nih.gov/pubmed/7657631 PubMed 9153434 http://www.ncbi.nlm.nih.gov/pubmed/9153434 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9558350 http://www.ncbi.nlm.nih.gov/pubmed/9558350 PubMed 9618257 http://www.ncbi.nlm.nih.gov/pubmed/9618257 RefSeq NP_417244 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417244 RefSeq WP_000211913 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000211913 SMR P38038 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P38038 STRING 511145.b2764 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2764&targetmode=cogs STRING COG0369 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0369&targetmode=cogs SUPFAM SSF52218 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52218 SUPFAM SSF63380 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63380 TIGRFAMs TIGR01931 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01931 UniProtKB CYSJ_ECOLI http://www.uniprot.org/uniprot/CYSJ_ECOLI UniProtKB-AC P38038 http://www.uniprot.org/uniprot/P38038 charge swissprot:CYSJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CYSJ_ECOLI eggNOG COG0369 http://eggnogapi.embl.de/nog_data/html/tree/COG0369 eggNOG ENOG4107EER http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107EER epestfind swissprot:CYSJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CYSJ_ECOLI garnier swissprot:CYSJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CYSJ_ECOLI helixturnhelix swissprot:CYSJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CYSJ_ECOLI hmoment swissprot:CYSJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CYSJ_ECOLI iep swissprot:CYSJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CYSJ_ECOLI inforesidue swissprot:CYSJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CYSJ_ECOLI octanol swissprot:CYSJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CYSJ_ECOLI pepcoil swissprot:CYSJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CYSJ_ECOLI pepdigest swissprot:CYSJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CYSJ_ECOLI pepinfo swissprot:CYSJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CYSJ_ECOLI pepnet swissprot:CYSJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CYSJ_ECOLI pepstats swissprot:CYSJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CYSJ_ECOLI pepwheel swissprot:CYSJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CYSJ_ECOLI pepwindow swissprot:CYSJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CYSJ_ECOLI sigcleave swissprot:CYSJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CYSJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4261036 9 # EcoGene EG13175 ftnB # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0005506 iron ion binding; IBA:GO_Central. # GO_function GO:0008199 ferric iron binding; IEA:InterPro. # GO_process GO:0006826 iron ion transport; IEA:InterPro. # GO_process GO:0006880 intracellular sequestering of iron ion; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # Gene3D 1.20.1260.10 -; 1. # IntAct P0A9A2 8 # InterPro IPR001519 Ferritin # InterPro IPR008331 Ferritin_DPS_dom # InterPro IPR009040 Ferritin-like_diiron # InterPro IPR009078 Ferritin-like_SF # InterPro IPR012347 Ferritin-rel # Organism FTNB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11431 PTHR11431 # PATRIC 32119129 VBIEscCol129921_1982 # PIR F64953 F64953 # PROSITE PS50905 FERRITIN_LIKE # Pfam PF00210 Ferritin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FTNB_ECOLI Bacterial non-heme ferritin-like protein # RefSeq NP_416415 NC_000913.3 # RefSeq WP_000179469 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA81671.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ferritin family. Prokaryotic subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ferritin-like diiron domain. {ECO:0000255|PROSITE-ProRule PRU00085}. # SUBCELLULAR LOCATION FTNB_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF47240 SSF47240 # eggNOG COG1528 LUCA # eggNOG ENOG4108UEC Bacteria BLAST swissprot:FTNB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FTNB_ECOLI BioCyc ECOL316407:JW1890-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1890-MONOMER BioCyc EcoCyc:G7033-MONOMER http://biocyc.org/getid?id=EcoCyc:G7033-MONOMER COG COG1528 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1528 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U39484 http://www.ebi.ac.uk/ena/data/view/U39484 EchoBASE EB2967 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2967 EcoGene EG13175 http://www.ecogene.org/geneInfo.php?eg_id=EG13175 EnsemblBacteria AAC74972 http://www.ensemblgenomes.org/id/AAC74972 EnsemblBacteria AAC74972 http://www.ensemblgenomes.org/id/AAC74972 EnsemblBacteria BAA15726 http://www.ensemblgenomes.org/id/BAA15726 EnsemblBacteria BAA15726 http://www.ensemblgenomes.org/id/BAA15726 EnsemblBacteria BAA15726 http://www.ensemblgenomes.org/id/BAA15726 EnsemblBacteria b1902 http://www.ensemblgenomes.org/id/b1902 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0008199 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008199 GO_process GO:0006826 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006826 GO_process GO:0006880 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006880 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.20.1260.10 http://www.cathdb.info/version/latest/superfamily/1.20.1260.10 GeneID 946407 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946407 HOGENOM HOG000223382 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000223382&db=HOGENOM6 InParanoid P0A9A2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9A2 IntAct P0A9A2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9A2* InterPro IPR001519 http://www.ebi.ac.uk/interpro/entry/IPR001519 InterPro IPR008331 http://www.ebi.ac.uk/interpro/entry/IPR008331 InterPro IPR009040 http://www.ebi.ac.uk/interpro/entry/IPR009040 InterPro IPR009078 http://www.ebi.ac.uk/interpro/entry/IPR009078 InterPro IPR012347 http://www.ebi.ac.uk/interpro/entry/IPR012347 KEGG_Gene ecj:JW1890 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1890 KEGG_Gene eco:b1902 http://www.genome.jp/dbget-bin/www_bget?eco:b1902 KEGG_Orthology KO:K02255 http://www.genome.jp/dbget-bin/www_bget?KO:K02255 OMA QSNVTHM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QSNVTHM PANTHER PTHR11431 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11431 PROSITE PS50905 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50905 PSORT swissprot:FTNB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FTNB_ECOLI PSORT-B swissprot:FTNB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FTNB_ECOLI PSORT2 swissprot:FTNB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FTNB_ECOLI Pfam PF00210 http://pfam.xfam.org/family/PF00210 Phobius swissprot:FTNB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FTNB_ECOLI PhylomeDB P0A9A2 http://phylomedb.org/?seqid=P0A9A2 ProteinModelPortal P0A9A2 http://www.proteinmodelportal.org/query/uniprot/P0A9A2 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416415 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416415 RefSeq WP_000179469 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000179469 SMR P0A9A2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9A2 STRING 511145.b1902 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1902&targetmode=cogs STRING COG1528 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1528&targetmode=cogs SUPFAM SSF47240 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47240 UniProtKB FTNB_ECOLI http://www.uniprot.org/uniprot/FTNB_ECOLI UniProtKB-AC P0A9A2 http://www.uniprot.org/uniprot/P0A9A2 charge swissprot:FTNB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FTNB_ECOLI eggNOG COG1528 http://eggnogapi.embl.de/nog_data/html/tree/COG1528 eggNOG ENOG4108UEC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UEC epestfind swissprot:FTNB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FTNB_ECOLI garnier swissprot:FTNB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FTNB_ECOLI helixturnhelix swissprot:FTNB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FTNB_ECOLI hmoment swissprot:FTNB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FTNB_ECOLI iep swissprot:FTNB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FTNB_ECOLI inforesidue swissprot:FTNB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FTNB_ECOLI octanol swissprot:FTNB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FTNB_ECOLI pepcoil swissprot:FTNB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FTNB_ECOLI pepdigest swissprot:FTNB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FTNB_ECOLI pepinfo swissprot:FTNB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FTNB_ECOLI pepnet swissprot:FTNB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FTNB_ECOLI pepstats swissprot:FTNB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FTNB_ECOLI pepwheel swissprot:FTNB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FTNB_ECOLI pepwindow swissprot:FTNB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FTNB_ECOLI sigcleave swissprot:FTNB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FTNB_ECOLI ## Database ID URL or Descriptions # BioGrid 4262602 21 # CDD cd07377 WHTH_GntR # EcoGene EG11733 yieP # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # Gene3D 1.20.120.530 -; 1. # InterPro IPR000524 Tscrpt_reg_HTH_GntR # InterPro IPR008920 TF_FadR/GntR_C # InterPro IPR011711 GntR_C # InterPro IPR011991 WHTH_DNA-bd_dom # Organism YIEP_ECOLI Escherichia coli (strain K12) # PATRIC 32123009 VBIEscCol129921_3880 # PRINTS PR00035 HTHGNTR # PROSITE PS50949 HTH_GNTR # Pfam PF00392 GntR # Pfam PF07729 FCD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIEP_ECOLI Uncharacterized HTH-type transcriptional regulator YieP # RefSeq WP_001131164 NZ_LN832404.1 # RefSeq YP_026245 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA62108.1; Type=Frameshift; Positions=21; Evidence={ECO 0000305}; # SIMILARITY Contains 1 HTH gntR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00307}. # SMART SM00345 HTH_GNTR # SMART SM00895 FCD # SUPFAM SSF46785 SSF46785 # SUPFAM SSF48008 SSF48008 # eggNOG COG2186 LUCA # eggNOG ENOG4107EJG Bacteria BLAST swissprot:YIEP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIEP_ECOLI BioCyc ECOL316407:JW5608-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5608-MONOMER BioCyc EcoCyc:EG11733-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11733-MONOMER DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1684 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1684 EcoGene EG11733 http://www.ecogene.org/geneInfo.php?eg_id=EG11733 EnsemblBacteria AAT48205 http://www.ensemblgenomes.org/id/AAT48205 EnsemblBacteria AAT48205 http://www.ensemblgenomes.org/id/AAT48205 EnsemblBacteria BAE77533 http://www.ensemblgenomes.org/id/BAE77533 EnsemblBacteria BAE77533 http://www.ensemblgenomes.org/id/BAE77533 EnsemblBacteria BAE77533 http://www.ensemblgenomes.org/id/BAE77533 EnsemblBacteria b3755 http://www.ensemblgenomes.org/id/b3755 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 1.20.120.530 http://www.cathdb.info/version/latest/superfamily/1.20.120.530 GeneID 948263 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948263 HOGENOM HOG000273996 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000273996&db=HOGENOM6 InterPro IPR000524 http://www.ebi.ac.uk/interpro/entry/IPR000524 InterPro IPR008920 http://www.ebi.ac.uk/interpro/entry/IPR008920 InterPro IPR011711 http://www.ebi.ac.uk/interpro/entry/IPR011711 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW5608 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5608 KEGG_Gene eco:b3755 http://www.genome.jp/dbget-bin/www_bget?eco:b3755 OMA MTRENFD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MTRENFD PRINTS PR00035 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00035 PROSITE PS50949 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50949 PSORT swissprot:YIEP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIEP_ECOLI PSORT-B swissprot:YIEP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIEP_ECOLI PSORT2 swissprot:YIEP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIEP_ECOLI Pfam PF00392 http://pfam.xfam.org/family/PF00392 Pfam PF07729 http://pfam.xfam.org/family/PF07729 Phobius swissprot:YIEP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIEP_ECOLI PhylomeDB P31475 http://phylomedb.org/?seqid=P31475 ProteinModelPortal P31475 http://www.proteinmodelportal.org/query/uniprot/P31475 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001131164 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001131164 RefSeq YP_026245 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026245 SMART SM00345 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00345 SMART SM00895 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00895 SMR P31475 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31475 STRING 511145.b3755 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3755&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SUPFAM SSF48008 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48008 UniProtKB YIEP_ECOLI http://www.uniprot.org/uniprot/YIEP_ECOLI UniProtKB-AC P31475 http://www.uniprot.org/uniprot/P31475 charge swissprot:YIEP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIEP_ECOLI eggNOG COG2186 http://eggnogapi.embl.de/nog_data/html/tree/COG2186 eggNOG ENOG4107EJG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107EJG epestfind swissprot:YIEP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIEP_ECOLI garnier swissprot:YIEP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIEP_ECOLI helixturnhelix swissprot:YIEP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIEP_ECOLI hmoment swissprot:YIEP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIEP_ECOLI iep swissprot:YIEP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIEP_ECOLI inforesidue swissprot:YIEP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIEP_ECOLI octanol swissprot:YIEP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIEP_ECOLI pepcoil swissprot:YIEP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIEP_ECOLI pepdigest swissprot:YIEP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIEP_ECOLI pepinfo swissprot:YIEP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIEP_ECOLI pepnet swissprot:YIEP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIEP_ECOLI pepstats swissprot:YIEP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIEP_ECOLI pepwheel swissprot:YIEP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIEP_ECOLI pepwindow swissprot:YIEP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIEP_ECOLI sigcleave swissprot:YIEP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIEP_ECOLI ## Database ID URL or Descriptions # BioGrid 4262440 13 # EcoGene EG12824 aaeX # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # HAMAP MF_01546 AaeX # INDUCTION AAEX_ECOLI Positively coregulated with aaeA and aaeB by AaeR. {ECO 0000255|HAMAP-Rule MF_01546, ECO 0000269|PubMed 15489430}. # InterPro IPR012451 DUF1656 # Organism AAEX_ECOLI Escherichia coli (strain K12) # PATRIC 32121910 VBIEscCol129921_3339 # PIR D65116 D65116 # Pfam PF07869 DUF1656 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Protein AaeX {ECO:0000255|HAMAP-Rule MF_01546} # RefSeq NP_417709 NC_000913.3 # RefSeq WP_000051841 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA58044.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the AaeX family. {ECO:0000255|HAMAP- Rule MF_01546}. # SUBCELLULAR LOCATION AAEX_ECOLI Cell membrane {ECO 0000255|HAMAP- Rule MF_01546}; Multi-pass membrane protein {ECO 0000255|HAMAP- Rule MF_01546}. BLAST swissprot:AAEX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AAEX_ECOLI BioCyc ECOL316407:JW5541-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5541-MONOMER BioCyc EcoCyc:G7687-MONOMER http://biocyc.org/getid?id=EcoCyc:G7687-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.186.21.7196-7204.2004 http://dx.doi.org/10.1128/JB.186.21.7196-7204.2004 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2675 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2675 EcoGene EG12824 http://www.ecogene.org/geneInfo.php?eg_id=EG12824 EnsemblBacteria AAC76274 http://www.ensemblgenomes.org/id/AAC76274 EnsemblBacteria AAC76274 http://www.ensemblgenomes.org/id/AAC76274 EnsemblBacteria BAE77285 http://www.ensemblgenomes.org/id/BAE77285 EnsemblBacteria BAE77285 http://www.ensemblgenomes.org/id/BAE77285 EnsemblBacteria BAE77285 http://www.ensemblgenomes.org/id/BAE77285 EnsemblBacteria b3242 http://www.ensemblgenomes.org/id/b3242 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 947751 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947751 HAMAP MF_01546 http://hamap.expasy.org/unirule/MF_01546 HOGENOM HOG000259373 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000259373&db=HOGENOM6 InterPro IPR012451 http://www.ebi.ac.uk/interpro/entry/IPR012451 KEGG_Gene ecj:JW5541 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5541 KEGG_Gene eco:b3242 http://www.genome.jp/dbget-bin/www_bget?eco:b3242 OMA IYDLVWH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IYDLVWH PSORT swissprot:AAEX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AAEX_ECOLI PSORT-B swissprot:AAEX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AAEX_ECOLI PSORT2 swissprot:AAEX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AAEX_ECOLI Pfam PF07869 http://pfam.xfam.org/family/PF07869 Phobius swissprot:AAEX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AAEX_ECOLI ProteinModelPortal P46478 http://www.proteinmodelportal.org/query/uniprot/P46478 PubMed 15489430 http://www.ncbi.nlm.nih.gov/pubmed/15489430 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417709 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417709 RefSeq WP_000051841 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000051841 SMR P46478 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P46478 STRING 511145.b3242 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3242&targetmode=cogs UniProtKB AAEX_ECOLI http://www.uniprot.org/uniprot/AAEX_ECOLI UniProtKB-AC P46478 http://www.uniprot.org/uniprot/P46478 charge swissprot:AAEX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AAEX_ECOLI epestfind swissprot:AAEX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AAEX_ECOLI garnier swissprot:AAEX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AAEX_ECOLI helixturnhelix swissprot:AAEX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AAEX_ECOLI hmoment swissprot:AAEX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AAEX_ECOLI iep swissprot:AAEX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AAEX_ECOLI inforesidue swissprot:AAEX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AAEX_ECOLI octanol swissprot:AAEX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AAEX_ECOLI pepcoil swissprot:AAEX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AAEX_ECOLI pepdigest swissprot:AAEX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AAEX_ECOLI pepinfo swissprot:AAEX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AAEX_ECOLI pepnet swissprot:AAEX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AAEX_ECOLI pepstats swissprot:AAEX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AAEX_ECOLI pepwheel swissprot:AAEX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AAEX_ECOLI pepwindow swissprot:AAEX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AAEX_ECOLI sigcleave swissprot:AAEX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AAEX_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: Note=kcat is 127 sec(-1). {ECO 0000269|PubMed:25225400}; # BioGrid 4261350 7 # CATALYTIC ACTIVITY LSRF_ECOLI Glycerone phosphate + acetyl-CoA = 3-hydroxy- 5-phosphonooxypentane-2,4-dione + coenzyme A. {ECO 0000255|HAMAP- Rule MF_02052, ECO 0000269|PubMed 25225400}. # EcoGene EG13810 lsrF # FUNCTION LSRF_ECOLI Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the transfer of an acetyl moiety from 3-hydroxy-5-phosphonooxypentane-2,4-dione to CoA to form glycerone phosphate and acetyl-CoA. {ECO 0000255|HAMAP-Rule MF_02052, ECO 0000269|PubMed 25225400}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups; IDA:EcoCyc. # GO_function GO:0016829 lyase activity; IEA:InterPro. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_function GO:0016829 lyase activity # Gene3D 3.20.20.70 -; 1. # HAMAP MF_02052 LsrF # INDUCTION LSRF_ECOLI In the absence of AI-2, repressed by LsrR. Induced by AI-2, via release of the LsrR repressor. In the absence of glucose, induced by cAMP-CRP by direct binding to the upstream region of the lsr promoter. {ECO 0000269|PubMed 15601708, ECO 0000269|PubMed 15743955}. # IntAct P76143 5 # InterPro IPR002915 DeoC/FbaB/lacD_aldolase # InterPro IPR013785 Aldolase_TIM # InterPro IPR033673 LsrF # KEGG_Brite ko01000 Enzymes # Organism LSRF_ECOLI Escherichia coli (strain K12) # PATRIC 32118330 VBIEscCol129921_1585 # PDB 3GKF X-ray; 2.90 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T=1-291 # PDB 3GLC X-ray; 2.50 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T=1-291 # PDB 3GND X-ray; 2.90 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T=1-291 # PDB 4P2V X-ray; 2.51 A; A/B/C/D/E/F/G/H/I/K=1-291 # PIR H64905 H64905 # PIRSF PIRSF038992 Aldolase_Ia # Pfam PF01791 DeoC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase {ECO:0000255|HAMAP-Rule MF_02052} # RefSeq NP_416034 NC_000913.3 # RefSeq WP_000774165 NZ_LN832404.1 # SIMILARITY Belongs to the DeoC/FbaB aldolase family. {ECO:0000255|HAMAP-Rule MF_02052, ECO:0000305}. # SMART SM01133 DeoC # SUBCELLULAR LOCATION LSRF_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_02052}. # SUBUNIT LSRF_ECOLI Homodecamer. {ECO 0000255|HAMAP-Rule MF_02052, ECO 0000269|PubMed 19714241}. # eggNOG COG1830 LUCA # eggNOG ENOG41061GT Bacteria BLAST swissprot:LSRF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LSRF_ECOLI BioCyc ECOL316407:JW1510-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1510-MONOMER BioCyc EcoCyc:G6804-MONOMER http://biocyc.org/getid?id=EcoCyc:G6804-MONOMER BioCyc MetaCyc:G6804-MONOMER http://biocyc.org/getid?id=MetaCyc:G6804-MONOMER COG COG1830 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1830 DIP DIP-12754N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12754N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.1408691111 http://dx.doi.org/10.1073/pnas.1408691111 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.187.1.238-248.2005 http://dx.doi.org/10.1128/JB.187.1.238-248.2005 DOI 10.1128/JB.187.6.2066-2076.2005 http://dx.doi.org/10.1128/JB.187.6.2066-2076.2005 DOI 10.1371/journal.pone.0006820 http://dx.doi.org/10.1371/journal.pone.0006820 EC_number EC:2.3.1.245 {ECO:0000255|HAMAP-Rule:MF_02052, ECO:0000269|PubMed:25225400} http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.245 {ECO:0000255|HAMAP-Rule:MF_02052, ECO:0000269|PubMed:25225400} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.3.1.245 {ECO:0000255|HAMAP-Rule:MF_02052, ECO:0000269|PubMed:25225400} http://enzyme.expasy.org/EC/2.3.1.245 {ECO:0000255|HAMAP-Rule:MF_02052, ECO:0000269|PubMed:25225400} EchoBASE EB3571 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3571 EcoGene EG13810 http://www.ecogene.org/geneInfo.php?eg_id=EG13810 EnsemblBacteria AAC74590 http://www.ensemblgenomes.org/id/AAC74590 EnsemblBacteria AAC74590 http://www.ensemblgenomes.org/id/AAC74590 EnsemblBacteria BAE76457 http://www.ensemblgenomes.org/id/BAE76457 EnsemblBacteria BAE76457 http://www.ensemblgenomes.org/id/BAE76457 EnsemblBacteria BAE76457 http://www.ensemblgenomes.org/id/BAE76457 EnsemblBacteria b1517 http://www.ensemblgenomes.org/id/b1517 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0016747 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016747 GO_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 946071 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946071 HAMAP MF_02052 http://hamap.expasy.org/unirule/MF_02052 HOGENOM HOG000224792 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000224792&db=HOGENOM6 InParanoid P76143 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76143 IntAct P76143 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76143* IntEnz 2.3.1.245 {ECO:0000255|HAMAP-Rule:MF_02052, ECO:0000269|PubMed:25225400} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.245 {ECO:0000255|HAMAP-Rule:MF_02052, ECO:0000269|PubMed:25225400} InterPro IPR002915 http://www.ebi.ac.uk/interpro/entry/IPR002915 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR033673 http://www.ebi.ac.uk/interpro/entry/IPR033673 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1510 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1510 KEGG_Gene eco:b1517 http://www.genome.jp/dbget-bin/www_bget?eco:b1517 KEGG_Orthology KO:K08321 http://www.genome.jp/dbget-bin/www_bget?KO:K08321 OMA IVRHGHR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IVRHGHR PDB 3GKF http://www.ebi.ac.uk/pdbe-srv/view/entry/3GKF PDB 3GLC http://www.ebi.ac.uk/pdbe-srv/view/entry/3GLC PDB 3GND http://www.ebi.ac.uk/pdbe-srv/view/entry/3GND PDB 4P2V http://www.ebi.ac.uk/pdbe-srv/view/entry/4P2V PDBsum 3GKF http://www.ebi.ac.uk/pdbsum/3GKF PDBsum 3GLC http://www.ebi.ac.uk/pdbsum/3GLC PDBsum 3GND http://www.ebi.ac.uk/pdbsum/3GND PDBsum 4P2V http://www.ebi.ac.uk/pdbsum/4P2V PSORT swissprot:LSRF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LSRF_ECOLI PSORT-B swissprot:LSRF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LSRF_ECOLI PSORT2 swissprot:LSRF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LSRF_ECOLI Pfam PF01791 http://pfam.xfam.org/family/PF01791 Phobius swissprot:LSRF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LSRF_ECOLI PhylomeDB P76143 http://phylomedb.org/?seqid=P76143 ProteinModelPortal P76143 http://www.proteinmodelportal.org/query/uniprot/P76143 PubMed 15601708 http://www.ncbi.nlm.nih.gov/pubmed/15601708 PubMed 15743955 http://www.ncbi.nlm.nih.gov/pubmed/15743955 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19714241 http://www.ncbi.nlm.nih.gov/pubmed/19714241 PubMed 25225400 http://www.ncbi.nlm.nih.gov/pubmed/25225400 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416034 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416034 RefSeq WP_000774165 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000774165 SMART SM01133 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01133 SMR P76143 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76143 STRING 511145.b1517 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1517&targetmode=cogs STRING COG1830 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1830&targetmode=cogs UniProtKB LSRF_ECOLI http://www.uniprot.org/uniprot/LSRF_ECOLI UniProtKB-AC P76143 http://www.uniprot.org/uniprot/P76143 charge swissprot:LSRF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LSRF_ECOLI eggNOG COG1830 http://eggnogapi.embl.de/nog_data/html/tree/COG1830 eggNOG ENOG41061GT http://eggnogapi.embl.de/nog_data/html/tree/ENOG41061GT epestfind swissprot:LSRF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LSRF_ECOLI garnier swissprot:LSRF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LSRF_ECOLI helixturnhelix swissprot:LSRF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LSRF_ECOLI hmoment swissprot:LSRF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LSRF_ECOLI iep swissprot:LSRF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LSRF_ECOLI inforesidue swissprot:LSRF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LSRF_ECOLI octanol swissprot:LSRF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LSRF_ECOLI pepcoil swissprot:LSRF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LSRF_ECOLI pepdigest swissprot:LSRF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LSRF_ECOLI pepinfo swissprot:LSRF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LSRF_ECOLI pepnet swissprot:LSRF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LSRF_ECOLI pepstats swissprot:LSRF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LSRF_ECOLI pepwheel swissprot:LSRF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LSRF_ECOLI pepwindow swissprot:LSRF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LSRF_ECOLI sigcleave swissprot:LSRF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LSRF_ECOLI ## Database ID URL or Descriptions # BioGrid 4261087 7 # CATALYTIC ACTIVITY NIRB_ECOLI Ammonia + 3 NAD(+) + 2 H(2)O = nitrite + 3 NADH. # COFACTOR Name=FAD; Xref=ChEBI:CHEBI 57692; # COFACTOR Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI 49883; Note=Binds 1 [4Fe-4S] cluster per subunit.; # COFACTOR Name=siroheme; Xref=ChEBI:CHEBI 60052; Note=Binds 1 siroheme per subunit.; # EcoGene EG10653 nirB # GO_component GO:0009344 nitrite reductase complex [NAD(P)H]; IDA:EcoCyc. # GO_function GO:0008942 nitrite reductase [NAD(P)H] activity; IDA:EcoCyc. # GO_function GO:0020037 heme binding; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0050660 flavin adenine dinucleotide binding; IDA:EcoCyc. # GO_function GO:0050661 NADP binding; IDA:EcoCyc. # GO_function GO:0051536 iron-sulfur cluster binding; IDA:EcoCyc. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0009061 anaerobic respiration; IEP:EcoCyc. # GO_process GO:0042128 nitrate assimilation; IEA:UniProtKB-UniPathway. # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0071941 nitrogen cycle metabolic process # Gene3D 3.50.50.60 -; 2. # InterPro IPR005117 NiRdtase/SiRdtase_haem-b_fer # InterPro IPR006066 NO2/SO3_Rdtase_FeS/sirohaem_BS # InterPro IPR006067 NO2/SO3_Rdtase_4Fe4S_dom # InterPro IPR007419 BFD-like_2Fe2S-bd_dom # InterPro IPR012744 Nitri_red_NirB # InterPro IPR017121 Nitrite_Rdtase_lsu # InterPro IPR023753 FAD/NAD-binding_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00910 Nitrogen metabolism # Organism NIRB_ECOLI Escherichia coli (strain K12) # PATHWAY NIRB_ECOLI Nitrogen metabolism; nitrate reduction (assimilation). # PATRIC 32122164 VBIEscCol129921_3459 # PIR H65130 H65130 # PIRSF PIRSF037149 NirB # PRINTS PR00397 SIROHAEM # PROSITE PS00365 NIR_SIR # Pfam PF01077 NIR_SIR # Pfam PF03460 NIR_SIR_ferr # Pfam PF04324 Fer2_BFD # Pfam PF07992 Pyr_redox_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NIRB_ECOLI Nitrite reductase (NADH) large subunit # RefSeq NP_417824 NC_000913.3 # RefSeq WP_000049208 NZ_LN832404.1 # SIMILARITY Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. {ECO 0000305}. # SUBUNIT NIRB_ECOLI Homodimer which associates with NirD. # SUPFAM SSF51905 SSF51905; 2 # SUPFAM SSF55124 SSF55124 # TIGRFAMs TIGR02374 nitri_red_nirB # eggNOG COG1251 LUCA # eggNOG ENOG4107QZF Bacteria BLAST swissprot:NIRB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NIRB_ECOLI BioCyc ECOL316407:JW3328-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3328-MONOMER BioCyc EcoCyc:NIRB-MONOMER http://biocyc.org/getid?id=EcoCyc:NIRB-MONOMER BioCyc MetaCyc:NIRB-MONOMER http://biocyc.org/getid?id=MetaCyc:NIRB-MONOMER COG COG1251 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1251 DOI 10.1016/0022-2836(87)90404-9 http://dx.doi.org/10.1016/0022-2836(87)90404-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/17.10.3865 http://dx.doi.org/10.1093/nar/17.10.3865 DOI 10.1111/j.1432-1033.1990.tb19125.x http://dx.doi.org/10.1111/j.1432-1033.1990.tb19125.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.7.1.15 http://www.genome.jp/dbget-bin/www_bget?EC:1.7.1.15 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X14202 http://www.ebi.ac.uk/ena/data/view/X14202 ENZYME 1.7.1.15 http://enzyme.expasy.org/EC/1.7.1.15 EchoBASE EB0647 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0647 EcoGene EG10653 http://www.ecogene.org/geneInfo.php?eg_id=EG10653 EnsemblBacteria AAC76390 http://www.ensemblgenomes.org/id/AAC76390 EnsemblBacteria AAC76390 http://www.ensemblgenomes.org/id/AAC76390 EnsemblBacteria BAE77925 http://www.ensemblgenomes.org/id/BAE77925 EnsemblBacteria BAE77925 http://www.ensemblgenomes.org/id/BAE77925 EnsemblBacteria BAE77925 http://www.ensemblgenomes.org/id/BAE77925 EnsemblBacteria b3365 http://www.ensemblgenomes.org/id/b3365 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009344 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009344 GO_function GO:0008942 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008942 GO_function GO:0020037 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0020037 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_function GO:0050661 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050661 GO_function GO:0051536 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051536 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0009061 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009061 GO_process GO:0042128 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042128 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0071941 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071941 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 GeneID 947868 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947868 HOGENOM HOG000196164 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000196164&db=HOGENOM6 InParanoid P08201 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P08201 IntAct P08201 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P08201* IntEnz 1.7.1.15 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.7.1.15 InterPro IPR005117 http://www.ebi.ac.uk/interpro/entry/IPR005117 InterPro IPR006066 http://www.ebi.ac.uk/interpro/entry/IPR006066 InterPro IPR006067 http://www.ebi.ac.uk/interpro/entry/IPR006067 InterPro IPR007419 http://www.ebi.ac.uk/interpro/entry/IPR007419 InterPro IPR012744 http://www.ebi.ac.uk/interpro/entry/IPR012744 InterPro IPR017121 http://www.ebi.ac.uk/interpro/entry/IPR017121 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3328 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3328 KEGG_Gene eco:b3365 http://www.genome.jp/dbget-bin/www_bget?eco:b3365 KEGG_Orthology KO:K00362 http://www.genome.jp/dbget-bin/www_bget?KO:K00362 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Reaction rn:R00787 http://www.genome.jp/dbget-bin/www_bget?rn:R00787 KEGG_Reaction rn:R00789 http://www.genome.jp/dbget-bin/www_bget?rn:R00789 OMA YREQARY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YREQARY PRINTS PR00397 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00397 PROSITE PS00365 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00365 PSORT swissprot:NIRB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NIRB_ECOLI PSORT-B swissprot:NIRB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NIRB_ECOLI PSORT2 swissprot:NIRB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NIRB_ECOLI Pfam PF01077 http://pfam.xfam.org/family/PF01077 Pfam PF03460 http://pfam.xfam.org/family/PF03460 Pfam PF04324 http://pfam.xfam.org/family/PF04324 Pfam PF07992 http://pfam.xfam.org/family/PF07992 Phobius swissprot:NIRB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NIRB_ECOLI PhylomeDB P08201 http://phylomedb.org/?seqid=P08201 ProteinModelPortal P08201 http://www.proteinmodelportal.org/query/uniprot/P08201 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2200672 http://www.ncbi.nlm.nih.gov/pubmed/2200672 PubMed 2445993 http://www.ncbi.nlm.nih.gov/pubmed/2445993 PubMed 2543955 http://www.ncbi.nlm.nih.gov/pubmed/2543955 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417824 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417824 RefSeq WP_000049208 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000049208 SMR P08201 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P08201 STRING 511145.b3365 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3365&targetmode=cogs STRING COG1251 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1251&targetmode=cogs SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 SUPFAM SSF55124 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55124 TIGRFAMs TIGR02374 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02374 UniProtKB NIRB_ECOLI http://www.uniprot.org/uniprot/NIRB_ECOLI UniProtKB-AC P08201 http://www.uniprot.org/uniprot/P08201 charge swissprot:NIRB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NIRB_ECOLI eggNOG COG1251 http://eggnogapi.embl.de/nog_data/html/tree/COG1251 eggNOG ENOG4107QZF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QZF epestfind swissprot:NIRB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NIRB_ECOLI garnier swissprot:NIRB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NIRB_ECOLI helixturnhelix swissprot:NIRB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NIRB_ECOLI hmoment swissprot:NIRB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NIRB_ECOLI iep swissprot:NIRB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NIRB_ECOLI inforesidue swissprot:NIRB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NIRB_ECOLI octanol swissprot:NIRB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NIRB_ECOLI pepcoil swissprot:NIRB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NIRB_ECOLI pepdigest swissprot:NIRB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NIRB_ECOLI pepinfo swissprot:NIRB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NIRB_ECOLI pepnet swissprot:NIRB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NIRB_ECOLI pepstats swissprot:NIRB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NIRB_ECOLI pepwheel swissprot:NIRB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NIRB_ECOLI pepwindow swissprot:NIRB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NIRB_ECOLI sigcleave swissprot:NIRB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NIRB_ECOLI ## Database ID URL or Descriptions # BioGrid 4259123 11 # EcoGene EG13925 ydgD # GO_function GO:0004252 serine-type endopeptidase activity; IEA:InterPro. # GOslim_function GO:0008233 peptidase activity # InterPro IPR001254 Trypsin_dom # InterPro IPR008256 Peptidase_S1B # InterPro IPR009003 Peptidase_S1_PA # InterPro IPR018114 TRYPSIN_HIS # InterPro IPR033116 TRYPSIN_SER # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # Organism YDGD_ECOLI Escherichia coli (strain K12) # PATRIC 32118498 VBIEscCol129921_1669 # PIR H64915 H64915 # PRINTS PR00839 V8PROTEASE # PROSITE PS00134 TRYPSIN_HIS # PROSITE PS00135 TRYPSIN_SER # Pfam PF00089 Trypsin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDGD_ECOLI Uncharacterized serine protease YdgD # RefSeq NP_416115 NC_000913.3 # RefSeq WP_001260865 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase S1B family. {ECO 0000305}. # SUPFAM SSF50494 SSF50494; 2 # eggNOG COG3591 LUCA # eggNOG ENOG4105CVW Bacteria BLAST swissprot:YDGD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDGD_ECOLI BioCyc ECOL316407:JW1590-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1590-MONOMER BioCyc EcoCyc:G6856-MONOMER http://biocyc.org/getid?id=EcoCyc:G6856-MONOMER COG COG3591 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3591 DIP DIP-11712N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11712N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.21.- http://www.genome.jp/dbget-bin/www_bget?EC:3.4.21.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.4.21.- http://enzyme.expasy.org/EC/3.4.21.- EchoBASE EB3684 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3684 EcoGene EG13925 http://www.ecogene.org/geneInfo.php?eg_id=EG13925 EnsemblBacteria AAC74670 http://www.ensemblgenomes.org/id/AAC74670 EnsemblBacteria AAC74670 http://www.ensemblgenomes.org/id/AAC74670 EnsemblBacteria BAE76480 http://www.ensemblgenomes.org/id/BAE76480 EnsemblBacteria BAE76480 http://www.ensemblgenomes.org/id/BAE76480 EnsemblBacteria BAE76480 http://www.ensemblgenomes.org/id/BAE76480 EnsemblBacteria b1598 http://www.ensemblgenomes.org/id/b1598 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004252 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GeneID 946436 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946436 HOGENOM HOG000120841 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120841&db=HOGENOM6 InParanoid P76176 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76176 IntEnz 3.4.21 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.21 InterPro IPR001254 http://www.ebi.ac.uk/interpro/entry/IPR001254 InterPro IPR008256 http://www.ebi.ac.uk/interpro/entry/IPR008256 InterPro IPR009003 http://www.ebi.ac.uk/interpro/entry/IPR009003 InterPro IPR018114 http://www.ebi.ac.uk/interpro/entry/IPR018114 InterPro IPR033116 http://www.ebi.ac.uk/interpro/entry/IPR033116 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW1590 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1590 KEGG_Gene eco:b1598 http://www.genome.jp/dbget-bin/www_bget?eco:b1598 KEGG_Orthology KO:K04775 http://www.genome.jp/dbget-bin/www_bget?KO:K04775 OMA WQAIGQL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WQAIGQL PRINTS PR00839 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00839 PROSITE PS00134 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00134 PROSITE PS00135 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00135 PSORT swissprot:YDGD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDGD_ECOLI PSORT-B swissprot:YDGD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDGD_ECOLI PSORT2 swissprot:YDGD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDGD_ECOLI Pfam PF00089 http://pfam.xfam.org/family/PF00089 Phobius swissprot:YDGD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDGD_ECOLI ProteinModelPortal P76176 http://www.proteinmodelportal.org/query/uniprot/P76176 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416115 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416115 RefSeq WP_001260865 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001260865 STRING 511145.b1598 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1598&targetmode=cogs STRING COG3591 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3591&targetmode=cogs SUPFAM SSF50494 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50494 UniProtKB YDGD_ECOLI http://www.uniprot.org/uniprot/YDGD_ECOLI UniProtKB-AC P76176 http://www.uniprot.org/uniprot/P76176 charge swissprot:YDGD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDGD_ECOLI eggNOG COG3591 http://eggnogapi.embl.de/nog_data/html/tree/COG3591 eggNOG ENOG4105CVW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CVW epestfind swissprot:YDGD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDGD_ECOLI garnier swissprot:YDGD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDGD_ECOLI helixturnhelix swissprot:YDGD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDGD_ECOLI hmoment swissprot:YDGD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDGD_ECOLI iep swissprot:YDGD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDGD_ECOLI inforesidue swissprot:YDGD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDGD_ECOLI octanol swissprot:YDGD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDGD_ECOLI pepcoil swissprot:YDGD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDGD_ECOLI pepdigest swissprot:YDGD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDGD_ECOLI pepinfo swissprot:YDGD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDGD_ECOLI pepnet swissprot:YDGD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDGD_ECOLI pepstats swissprot:YDGD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDGD_ECOLI pepwheel swissprot:YDGD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDGD_ECOLI pepwindow swissprot:YDGD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDGD_ECOLI sigcleave swissprot:YDGD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDGD_ECOLI ## Database ID URL or Descriptions # AltName FABG_ECOLI 3-ketoacyl-acyl carrier protein reductase # AltName FABG_ECOLI Beta-Ketoacyl-acyl carrier protein reductase # AltName FABG_ECOLI Beta-ketoacyl-ACP reductase # BIOPHYSICOCHEMICAL PROPERTIES pH dependence: Optimum pH is between 6.0 and 7.0. {ECO 0000269|PubMed:4381013}; # BRENDA 1.1.1.100 2026 # BioGrid 4260080 228 # CATALYTIC ACTIVITY (3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl-carrier-protein] + NADPH. {ECO:0000269|PubMed 8631920}. # ENZYME REGULATION Inhibited by cinnamic acid derivatives. {ECO:0000269|PubMed 18977209}. # EcoGene EG11318 fabG # FUNCTION FABG_ECOLI Catalyzes the NADPH-dependent reduction of beta- ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. {ECO 0000269|PubMed 14996818, ECO 0000269|PubMed 8631920}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; IMP:UniProtKB. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0050661 NADP binding; IDA:UniProtKB. # GO_function GO:0051287 NAD binding; IEA:InterPro. # GO_function GO:0102132 3-oxo-pimeloyl-[acp] methyl ester reductase activity; IEA:UniProtKB-EC. # GO_process GO:0006633 fatty acid biosynthetic process; IMP:EcoCyc. # GO_process GO:0008610 lipid biosynthetic process; IMP:EcoCyc. # GO_process GO:0009102 biotin biosynthetic process; IMP:EcoCyc. # GO_process GO:0030497 fatty acid elongation; IMP:UniProtKB. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.720 -; 1. # IntAct P0AEK2 6 # InterPro IPR002347 SDR_fam # InterPro IPR011284 3oxo_ACP_reduc # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR020904 Sc_DH/Rdtase_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01004 Lipid biosynthesis proteins # KEGG_Pathway ko00061 Fatty acid biosynthesis # KEGG_Pathway ko00780 Biotin metabolism # KEGG_Pathway ko01040 Biosynthesis of unsaturated fatty acids # MISCELLANEOUS FABG_ECOLI Calcium ions stabilize the structure, and may inhibit FabG activity by obstructing access to the active site. # Organism FABG_ECOLI Escherichia coli (strain K12) # PANTHER PTHR24322 PTHR24322; 2 # PATHWAY FABG_ECOLI Lipid metabolism; fatty acid biosynthesis. # PATRIC 32117427 VBIEscCol129921_1136 # PDB 1I01 X-ray; 2.60 A; A/B/C/D/E/F/G/H=1-244 # PDB 1Q7B X-ray; 2.05 A; A/B/C/D=1-244 # PDB 1Q7C X-ray; 2.50 A; A/B=1-244 # PIR B64853 B42147 # PRINTS PR00080 SDRFAMILY # PRINTS PR00081 GDHRDH # PROSITE PS00061 ADH_SHORT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FABG_ECOLI 3-oxoacyl-[acyl-carrier-protein] reductase FabG # RefSeq NP_415611 NC_000913.3 # RefSeq WP_001008535 NZ_LN832404.1 # SIMILARITY Belongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO 0000305}. # SUBUNIT FABG_ECOLI Homotetramer. {ECO 0000269|PubMed 11669613, ECO 0000269|PubMed 15016358}. # SUPFAM SSF51735 SSF51735 # TIGRFAMs TIGR01830 3oxo_ACP_reduc # eggNOG ENOG4105CHR Bacteria # eggNOG ENOG410XNW1 LUCA BLAST swissprot:FABG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FABG_ECOLI BioCyc ECOL316407:JW1079-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1079-MONOMER BioCyc EcoCyc:3-OXOACYL-ACP-REDUCT-MONOMER http://biocyc.org/getid?id=EcoCyc:3-OXOACYL-ACP-REDUCT-MONOMER BioCyc MetaCyc:3-OXOACYL-ACP-REDUCT-MONOMER http://biocyc.org/getid?id=MetaCyc:3-OXOACYL-ACP-REDUCT-MONOMER COG COG1028 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1028 DIP DIP-31869N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31869N DOI 10.1016/j.cbi.2008.09.030 http://dx.doi.org/10.1016/j.cbi.2008.09.030 DOI 10.1016/j.str.2004.02.008 http://dx.doi.org/10.1016/j.str.2004.02.008 DOI 10.1021/bi010737g http://dx.doi.org/10.1021/bi010737g DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.271.18.10996 http://dx.doi.org/10.1074/jbc.271.18.10996 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.186.6.1869-1878.2004 http://dx.doi.org/10.1128/JB.186.6.1869-1878.2004 EC_number EC:1.1.1.100 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.100 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M84991 http://www.ebi.ac.uk/ena/data/view/M84991 EMBL M87040 http://www.ebi.ac.uk/ena/data/view/M87040 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.1.1.100 http://enzyme.expasy.org/EC/1.1.1.100 EchoBASE EB1294 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1294 EcoGene EG11318 http://www.ecogene.org/geneInfo.php?eg_id=EG11318 EnsemblBacteria AAC74177 http://www.ensemblgenomes.org/id/AAC74177 EnsemblBacteria AAC74177 http://www.ensemblgenomes.org/id/AAC74177 EnsemblBacteria BAA35901 http://www.ensemblgenomes.org/id/BAA35901 EnsemblBacteria BAA35901 http://www.ensemblgenomes.org/id/BAA35901 EnsemblBacteria BAA35901 http://www.ensemblgenomes.org/id/BAA35901 EnsemblBacteria b1093 http://www.ensemblgenomes.org/id/b1093 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004316 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004316 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0050661 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050661 GO_function GO:0051287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051287 GO_function GO:0102132 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0102132 GO_process GO:0006633 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006633 GO_process GO:0008610 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008610 GO_process GO:0009102 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009102 GO_process GO:0030497 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030497 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 945645 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945645 InParanoid P0AEK2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEK2 IntAct P0AEK2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEK2* IntEnz 1.1.1.100 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.100 InterPro IPR002347 http://www.ebi.ac.uk/interpro/entry/IPR002347 InterPro IPR011284 http://www.ebi.ac.uk/interpro/entry/IPR011284 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR020904 http://www.ebi.ac.uk/interpro/entry/IPR020904 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01004 http://www.genome.jp/dbget-bin/www_bget?ko01004 KEGG_Gene ecj:JW1079 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1079 KEGG_Gene eco:b1093 http://www.genome.jp/dbget-bin/www_bget?eco:b1093 KEGG_Orthology KO:K00059 http://www.genome.jp/dbget-bin/www_bget?KO:K00059 KEGG_Pathway ko00061 http://www.genome.jp/kegg-bin/show_pathway?ko00061 KEGG_Pathway ko00780 http://www.genome.jp/kegg-bin/show_pathway?ko00780 KEGG_Pathway ko01040 http://www.genome.jp/kegg-bin/show_pathway?ko01040 KEGG_Reaction rn:R04533 http://www.genome.jp/dbget-bin/www_bget?rn:R04533 KEGG_Reaction rn:R04534 http://www.genome.jp/dbget-bin/www_bget?rn:R04534 KEGG_Reaction rn:R04536 http://www.genome.jp/dbget-bin/www_bget?rn:R04536 KEGG_Reaction rn:R04543 http://www.genome.jp/dbget-bin/www_bget?rn:R04543 KEGG_Reaction rn:R04566 http://www.genome.jp/dbget-bin/www_bget?rn:R04566 KEGG_Reaction rn:R04953 http://www.genome.jp/dbget-bin/www_bget?rn:R04953 KEGG_Reaction rn:R04964 http://www.genome.jp/dbget-bin/www_bget?rn:R04964 KEGG_Reaction rn:R07759 http://www.genome.jp/dbget-bin/www_bget?rn:R07759 KEGG_Reaction rn:R07763 http://www.genome.jp/dbget-bin/www_bget?rn:R07763 KEGG_Reaction rn:R10116 http://www.genome.jp/dbget-bin/www_bget?rn:R10116 KEGG_Reaction rn:R10120 http://www.genome.jp/dbget-bin/www_bget?rn:R10120 MINT MINT-1232516 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1232516 OMA MKDEDWN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MKDEDWN PANTHER PTHR24322 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24322 PDB 1I01 http://www.ebi.ac.uk/pdbe-srv/view/entry/1I01 PDB 1Q7B http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q7B PDB 1Q7C http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q7C PDBsum 1I01 http://www.ebi.ac.uk/pdbsum/1I01 PDBsum 1Q7B http://www.ebi.ac.uk/pdbsum/1Q7B PDBsum 1Q7C http://www.ebi.ac.uk/pdbsum/1Q7C PRINTS PR00080 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00080 PRINTS PR00081 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00081 PROSITE PS00061 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00061 PSORT swissprot:FABG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FABG_ECOLI PSORT-B swissprot:FABG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FABG_ECOLI PSORT2 swissprot:FABG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FABG_ECOLI Phobius swissprot:FABG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FABG_ECOLI PhylomeDB P0AEK2 http://phylomedb.org/?seqid=P0AEK2 ProteinModelPortal P0AEK2 http://www.proteinmodelportal.org/query/uniprot/P0AEK2 PubMed 11669613 http://www.ncbi.nlm.nih.gov/pubmed/11669613 PubMed 1314802 http://www.ncbi.nlm.nih.gov/pubmed/1314802 PubMed 14996818 http://www.ncbi.nlm.nih.gov/pubmed/14996818 PubMed 15016358 http://www.ncbi.nlm.nih.gov/pubmed/15016358 PubMed 1556094 http://www.ncbi.nlm.nih.gov/pubmed/1556094 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18977209 http://www.ncbi.nlm.nih.gov/pubmed/18977209 PubMed 4381013 http://www.ncbi.nlm.nih.gov/pubmed/4381013 PubMed 8631920 http://www.ncbi.nlm.nih.gov/pubmed/8631920 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415611 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415611 RefSeq WP_001008535 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001008535 SMR P0AEK2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEK2 STRING 511145.b1093 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1093&targetmode=cogs STRING COG1028 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1028&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 TIGRFAMs TIGR01830 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01830 UniProtKB FABG_ECOLI http://www.uniprot.org/uniprot/FABG_ECOLI UniProtKB-AC P0AEK2 http://www.uniprot.org/uniprot/P0AEK2 charge swissprot:FABG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FABG_ECOLI eggNOG ENOG4105CHR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CHR eggNOG ENOG410XNW1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNW1 epestfind swissprot:FABG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FABG_ECOLI garnier swissprot:FABG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FABG_ECOLI helixturnhelix swissprot:FABG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FABG_ECOLI hmoment swissprot:FABG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FABG_ECOLI iep swissprot:FABG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FABG_ECOLI inforesidue swissprot:FABG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FABG_ECOLI octanol swissprot:FABG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FABG_ECOLI pepcoil swissprot:FABG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FABG_ECOLI pepdigest swissprot:FABG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FABG_ECOLI pepinfo swissprot:FABG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FABG_ECOLI pepnet swissprot:FABG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FABG_ECOLI pepstats swissprot:FABG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FABG_ECOLI pepwheel swissprot:FABG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FABG_ECOLI pepwindow swissprot:FABG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FABG_ECOLI sigcleave swissprot:FABG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FABG_ECOLI ## Database ID URL or Descriptions # AltName RHAS_ECOLI L-rhamnose operon regulatory protein RhaS # BioGrid 4260998 4 # EcoGene EG10843 rhaS # FUNCTION RHAS_ECOLI Activates expression of the rhaBAD and rhaT operons. {ECO 0000269|PubMed 8230210, ECO 0000269|PubMed 8757746}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0000987 core promoter proximal region sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0003677 DNA binding; IMP:EcoCyc. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IMP:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IMP:EcoCyc. # GO_process GO:0019299 rhamnose metabolic process; IEA:UniProtKB-HAMAP. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.10.60 -; 2. # Gene3D 2.60.120.10 -; 1. # HAMAP MF_01534 HTH_type_RhaS # INDUCTION Induced by RhaR in response to L-rhamnose. Binding of the cAMP receptor protein (CRP) is required for full expression. {ECO:0000269|PubMed 8230210}. # IntAct P09377 24 # InterPro IPR003313 AraC-bd # InterPro IPR009057 Homeodomain-like # InterPro IPR014710 RmlC-like_jellyroll # InterPro IPR018060 HTH_AraC # InterPro IPR018062 HTH_AraC-typ_CS # InterPro IPR020449 Tscrpt_reg_HTH_AraC-type # InterPro IPR023609 Tscrpt_reg_HTH_RhaS # KEGG_Brite ko03000 Transcription factors # Organism RHAS_ECOLI Escherichia coli (strain K12) # PATRIC 32123321 VBIEscCol129921_4021 # PIR S40849 S40849 # PRINTS PR00032 HTHARAC # PROSITE PS00041 HTH_ARAC_FAMILY_1 # PROSITE PS01124 HTH_ARAC_FAMILY_2 # Pfam PF02311 AraC_binding # Pfam PF12833 HTH_18 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RHAS_ECOLI HTH-type transcriptional activator RhaS # RefSeq NP_418341 NC_000913.3 # RefSeq WP_000217137 NZ_LN832404.1 # SIMILARITY Contains 2 HTH araC/xylS-type DNA-binding domains. {ECO 0000305}. # SMART SM00342 HTH_ARAC # SUBCELLULAR LOCATION RHAS_ECOLI Cytoplasm. # SUBUNIT Binds DNA as a dimer. {ECO 0000305}. # SUPFAM SSF46689 SSF46689; 2 # SUPFAM SSF51215 SSF51215 # eggNOG ENOG4107S4Z Bacteria # eggNOG ENOG410XT8S LUCA BLAST swissprot:RHAS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RHAS_ECOLI BioCyc ECOL316407:JW3876-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3876-MONOMER BioCyc EcoCyc:PD00221 http://biocyc.org/getid?id=EcoCyc:PD00221 COG COG2207 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2207 DIP DIP-10694N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10694N DOI 10.1006/jmbi.1993.1565 http://dx.doi.org/10.1006/jmbi.1993.1565 DOI 10.1016/0022-2836(87)90405-0 http://dx.doi.org/10.1016/0022-2836(87)90405-0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.17.4959-4969.2000 http://dx.doi.org/10.1128/JB.182.17.4959-4969.2000 DOI 10.1128/JB.182.23.6774-6782.2000 http://dx.doi.org/10.1128/JB.182.23.6774-6782.2000 DOI 10.1128/JB.186.18.6277-6285.2004 http://dx.doi.org/10.1128/JB.186.18.6277-6285.2004 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X06058 http://www.ebi.ac.uk/ena/data/view/X06058 EchoBASE EB0836 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0836 EcoGene EG10843 http://www.ecogene.org/geneInfo.php?eg_id=EG10843 EnsemblBacteria AAC76887 http://www.ensemblgenomes.org/id/AAC76887 EnsemblBacteria AAC76887 http://www.ensemblgenomes.org/id/AAC76887 EnsemblBacteria BAE77404 http://www.ensemblgenomes.org/id/BAE77404 EnsemblBacteria BAE77404 http://www.ensemblgenomes.org/id/BAE77404 EnsemblBacteria BAE77404 http://www.ensemblgenomes.org/id/BAE77404 EnsemblBacteria b3905 http://www.ensemblgenomes.org/id/b3905 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000987 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000987 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0019299 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019299 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 Gene3D 2.60.120.10 http://www.cathdb.info/version/latest/superfamily/2.60.120.10 GeneID 948397 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948397 HAMAP MF_01534 http://hamap.expasy.org/unirule/MF_01534 HOGENOM HOG000290513 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000290513&db=HOGENOM6 InParanoid P09377 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P09377 IntAct P09377 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P09377* InterPro IPR003313 http://www.ebi.ac.uk/interpro/entry/IPR003313 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR014710 http://www.ebi.ac.uk/interpro/entry/IPR014710 InterPro IPR018060 http://www.ebi.ac.uk/interpro/entry/IPR018060 InterPro IPR018062 http://www.ebi.ac.uk/interpro/entry/IPR018062 InterPro IPR020449 http://www.ebi.ac.uk/interpro/entry/IPR020449 InterPro IPR023609 http://www.ebi.ac.uk/interpro/entry/IPR023609 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW3876 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3876 KEGG_Gene eco:b3905 http://www.genome.jp/dbget-bin/www_bget?eco:b3905 KEGG_Orthology KO:K02855 http://www.genome.jp/dbget-bin/www_bget?KO:K02855 MINT MINT-1305270 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1305270 OMA YAIAIEP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YAIAIEP PRINTS PR00032 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00032 PROSITE PS00041 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00041 PROSITE PS01124 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01124 PSORT swissprot:RHAS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RHAS_ECOLI PSORT-B swissprot:RHAS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RHAS_ECOLI PSORT2 swissprot:RHAS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RHAS_ECOLI Pfam PF02311 http://pfam.xfam.org/family/PF02311 Pfam PF12833 http://pfam.xfam.org/family/PF12833 Phobius swissprot:RHAS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RHAS_ECOLI PhylomeDB P09377 http://phylomedb.org/?seqid=P09377 ProteinModelPortal P09377 http://www.proteinmodelportal.org/query/uniprot/P09377 PubMed 10464186 http://www.ncbi.nlm.nih.gov/pubmed/10464186 PubMed 10940041 http://www.ncbi.nlm.nih.gov/pubmed/10940041 PubMed 11073923 http://www.ncbi.nlm.nih.gov/pubmed/11073923 PubMed 15342598 http://www.ncbi.nlm.nih.gov/pubmed/15342598 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3316663 http://www.ncbi.nlm.nih.gov/pubmed/3316663 PubMed 8230210 http://www.ncbi.nlm.nih.gov/pubmed/8230210 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 8757746 http://www.ncbi.nlm.nih.gov/pubmed/8757746 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418341 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418341 RefSeq WP_000217137 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000217137 SMART SM00342 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00342 SMR P09377 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P09377 STRING 511145.b3905 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3905&targetmode=cogs STRING COG2207 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2207&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF51215 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51215 UniProtKB RHAS_ECOLI http://www.uniprot.org/uniprot/RHAS_ECOLI UniProtKB-AC P09377 http://www.uniprot.org/uniprot/P09377 charge swissprot:RHAS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RHAS_ECOLI eggNOG ENOG4107S4Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107S4Z eggNOG ENOG410XT8S http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XT8S epestfind swissprot:RHAS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RHAS_ECOLI garnier swissprot:RHAS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RHAS_ECOLI helixturnhelix swissprot:RHAS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RHAS_ECOLI hmoment swissprot:RHAS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RHAS_ECOLI iep swissprot:RHAS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RHAS_ECOLI inforesidue swissprot:RHAS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RHAS_ECOLI octanol swissprot:RHAS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RHAS_ECOLI pepcoil swissprot:RHAS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RHAS_ECOLI pepdigest swissprot:RHAS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RHAS_ECOLI pepinfo swissprot:RHAS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RHAS_ECOLI pepnet swissprot:RHAS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RHAS_ECOLI pepstats swissprot:RHAS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RHAS_ECOLI pepwheel swissprot:RHAS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RHAS_ECOLI pepwindow swissprot:RHAS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RHAS_ECOLI sigcleave swissprot:RHAS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RHAS_ECOLI ## Database ID URL or Descriptions # BioGrid 4262575 4 # EcoGene EG11712 yidQ # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_process GO:0006950 response to stress # InterPro IPR010780 DUF1375 # Organism YIDQ_ECOLI Escherichia coli (strain K12) # PATRIC 32122871 VBIEscCol129921_3811 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF07119 DUF1375 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIDQ_ECOLI Uncharacterized protein YidQ # RefSeq NP_418143 NC_000913.3 # RefSeq WP_000620888 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA62040.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY To E.coli YceK. {ECO 0000305}. # eggNOG COG5645 LUCA # eggNOG ENOG4105R2A Bacteria BLAST swissprot:YIDQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIDQ_ECOLI BioCyc ECOL316407:JW5633-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5633-MONOMER BioCyc EcoCyc:EG11712-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11712-MONOMER DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1663 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1663 EcoGene EG11712 http://www.ecogene.org/geneInfo.php?eg_id=EG11712 EnsemblBacteria AAC76711 http://www.ensemblgenomes.org/id/AAC76711 EnsemblBacteria AAC76711 http://www.ensemblgenomes.org/id/AAC76711 EnsemblBacteria BAE77606 http://www.ensemblgenomes.org/id/BAE77606 EnsemblBacteria BAE77606 http://www.ensemblgenomes.org/id/BAE77606 EnsemblBacteria BAE77606 http://www.ensemblgenomes.org/id/BAE77606 EnsemblBacteria b3688 http://www.ensemblgenomes.org/id/b3688 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 948199 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948199 HOGENOM HOG000126348 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126348&db=HOGENOM6 InterPro IPR010780 http://www.ebi.ac.uk/interpro/entry/IPR010780 KEGG_Gene ecj:JW5633 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5633 KEGG_Gene eco:b3688 http://www.genome.jp/dbget-bin/www_bget?eco:b3688 OMA ADAQETN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ADAQETN PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YIDQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIDQ_ECOLI PSORT-B swissprot:YIDQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIDQ_ECOLI PSORT2 swissprot:YIDQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIDQ_ECOLI Pfam PF07119 http://pfam.xfam.org/family/PF07119 Phobius swissprot:YIDQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIDQ_ECOLI ProteinModelPortal P0ADM4 http://www.proteinmodelportal.org/query/uniprot/P0ADM4 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418143 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418143 RefSeq WP_000620888 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000620888 STRING 511145.b3688 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3688&targetmode=cogs UniProtKB YIDQ_ECOLI http://www.uniprot.org/uniprot/YIDQ_ECOLI UniProtKB-AC P0ADM4 http://www.uniprot.org/uniprot/P0ADM4 charge swissprot:YIDQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIDQ_ECOLI eggNOG COG5645 http://eggnogapi.embl.de/nog_data/html/tree/COG5645 eggNOG ENOG4105R2A http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105R2A epestfind swissprot:YIDQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIDQ_ECOLI garnier swissprot:YIDQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIDQ_ECOLI helixturnhelix swissprot:YIDQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIDQ_ECOLI hmoment swissprot:YIDQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIDQ_ECOLI iep swissprot:YIDQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIDQ_ECOLI inforesidue swissprot:YIDQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIDQ_ECOLI octanol swissprot:YIDQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIDQ_ECOLI pepcoil swissprot:YIDQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIDQ_ECOLI pepdigest swissprot:YIDQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIDQ_ECOLI pepinfo swissprot:YIDQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIDQ_ECOLI pepnet swissprot:YIDQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIDQ_ECOLI pepstats swissprot:YIDQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIDQ_ECOLI pepwheel swissprot:YIDQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIDQ_ECOLI pepwindow swissprot:YIDQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIDQ_ECOLI sigcleave swissprot:YIDQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIDQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4263546 10 # DISRUPTION PHENOTYPE Grows poorly in the absence of zinc. {ECO:0000269|PubMed 19377097}. # EcoGene EG14326 ykgM # GO_component GO:0005840 ribosome; IEA:UniProtKB-KW. # GO_function GO:0003735 structural constituent of ribosome; IEA:InterPro. # GO_process GO:0006412 translation; IEA:UniProtKB-HAMAP. # GO_process GO:0034224 cellular response to zinc ion starvation; IMP:EcoCyc. # GOslim_component GO:0005840 ribosome # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_process GO:0006412 translation # GOslim_process GO:0006950 response to stress # HAMAP MF_00502 Ribosomal_L31_2 # INDUCTION RL31B_ECOLI Maximally induced 30 minutes under zinc-limiting conditions, still induced in stationary phase; repressed by the zinc uptake regulation protein Zur. Probably part of the rpmE2- rpmJ2 operon. {ECO 0000269|PubMed 19377097, ECO 0000269|PubMed 19734316, ECO 0000269|PubMed 22196016}. # IntAct P0A7N1 2 # InterPro IPR002150 Ribosomal_L31 # InterPro IPR027493 Ribosomal_L31_B # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # Organism RL31B_ECOLI Escherichia coli (strain K12) # PATRIC 32115717 VBIEscCol129921_0301 # PIR H64755 H64755 # PRINTS PR01249 RIBOSOMALL31 # PROSITE PS01143 RIBOSOMAL_L31 # Pfam PF01197 Ribosomal_L31 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RL31B_ECOLI 50S ribosomal protein L31 type B # RefSeq NP_414830 NC_000913.3 # RefSeq WP_000803998 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18024.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ribosomal protein L31P family. Type B subfamily. {ECO 0000305}. # SUBUNIT Part of the 50S ribosomal subunit. {ECO 0000250}. # TIGRFAMs TIGR00105 L31 # eggNOG COG0254 LUCA # eggNOG ENOG4105NRA Bacteria BLAST swissprot:RL31B_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RL31B_ECOLI BioCyc ECOL316407:JW5035-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5035-MONOMER BioCyc EcoCyc:G6167-MONOMER http://biocyc.org/getid?id=EcoCyc:G6167-MONOMER COG COG0254 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0254 DOI 10.1016/j.jinorgbio.2011.11.022 http://dx.doi.org/10.1016/j.jinorgbio.2011.11.022 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.1733691100 http://dx.doi.org/10.1073/pnas.1733691100 DOI 10.1074/jbc.M109.001503 http://dx.doi.org/10.1074/jbc.M109.001503 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00872-09 http://dx.doi.org/10.1128/JB.00872-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB4072 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4072 EcoGene EG14326 http://www.ecogene.org/geneInfo.php?eg_id=EG14326 EnsemblBacteria AAC73399 http://www.ensemblgenomes.org/id/AAC73399 EnsemblBacteria AAC73399 http://www.ensemblgenomes.org/id/AAC73399 EnsemblBacteria BAE76081 http://www.ensemblgenomes.org/id/BAE76081 EnsemblBacteria BAE76081 http://www.ensemblgenomes.org/id/BAE76081 EnsemblBacteria BAE76081 http://www.ensemblgenomes.org/id/BAE76081 EnsemblBacteria b0296 http://www.ensemblgenomes.org/id/b0296 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005840 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005840 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GO_process GO:0034224 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034224 GOslim_component GO:0005840 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005840 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 944960 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944960 HAMAP MF_00502 http://hamap.expasy.org/unirule/MF_00502 HOGENOM HOG000284894 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000284894&db=HOGENOM6 InParanoid P0A7N1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7N1 IntAct P0A7N1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7N1* InterPro IPR002150 http://www.ebi.ac.uk/interpro/entry/IPR002150 InterPro IPR027493 http://www.ebi.ac.uk/interpro/entry/IPR027493 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW5035 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5035 KEGG_Gene eco:b0296 http://www.genome.jp/dbget-bin/www_bget?eco:b0296 KEGG_Orthology KO:K02909 http://www.genome.jp/dbget-bin/www_bget?KO:K02909 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 OMA FKDMSND http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FKDMSND PRINTS PR01249 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01249 PROSITE PS01143 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01143 PSORT swissprot:RL31B_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RL31B_ECOLI PSORT-B swissprot:RL31B_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RL31B_ECOLI PSORT2 swissprot:RL31B_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RL31B_ECOLI Pfam PF01197 http://pfam.xfam.org/family/PF01197 Phobius swissprot:RL31B_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RL31B_ECOLI PhylomeDB P0A7N1 http://phylomedb.org/?seqid=P0A7N1 ProteinModelPortal P0A7N1 http://www.proteinmodelportal.org/query/uniprot/P0A7N1 PubMed 12904577 http://www.ncbi.nlm.nih.gov/pubmed/12904577 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19377097 http://www.ncbi.nlm.nih.gov/pubmed/19377097 PubMed 19734316 http://www.ncbi.nlm.nih.gov/pubmed/19734316 PubMed 22196016 http://www.ncbi.nlm.nih.gov/pubmed/22196016 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414830 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414830 RefSeq WP_000803998 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000803998 STRING 511145.b0296 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0296&targetmode=cogs STRING COG0254 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0254&targetmode=cogs SWISS-2DPAGE P0A7N1 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A7N1 TIGRFAMs TIGR00105 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00105 UniProtKB RL31B_ECOLI http://www.uniprot.org/uniprot/RL31B_ECOLI UniProtKB-AC P0A7N1 http://www.uniprot.org/uniprot/P0A7N1 charge swissprot:RL31B_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RL31B_ECOLI eggNOG COG0254 http://eggnogapi.embl.de/nog_data/html/tree/COG0254 eggNOG ENOG4105NRA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105NRA epestfind swissprot:RL31B_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RL31B_ECOLI garnier swissprot:RL31B_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RL31B_ECOLI helixturnhelix swissprot:RL31B_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RL31B_ECOLI hmoment swissprot:RL31B_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RL31B_ECOLI iep swissprot:RL31B_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RL31B_ECOLI inforesidue swissprot:RL31B_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RL31B_ECOLI octanol swissprot:RL31B_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RL31B_ECOLI pepcoil swissprot:RL31B_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RL31B_ECOLI pepdigest swissprot:RL31B_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RL31B_ECOLI pepinfo swissprot:RL31B_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RL31B_ECOLI pepnet swissprot:RL31B_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RL31B_ECOLI pepstats swissprot:RL31B_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RL31B_ECOLI pepwheel swissprot:RL31B_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RL31B_ECOLI pepwindow swissprot:RL31B_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RL31B_ECOLI sigcleave swissprot:RL31B_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RL31B_ECOLI ## Database ID URL or Descriptions # AltName PAAE_ECOLI 1,2-phenylacetyl-CoA epoxidase, reductase subunit # AltName PAAE_ECOLI 1,2-phenylacetyl-CoA monooxygenase, subunit E # BioGrid 4260178 205 # CDD cd00207 fer2 # COFACTOR PAAE_ECOLI Name=FAD; Xref=ChEBI CHEBI 57692; Evidence={ECO 0000269|PubMed 21247899}; # COFACTOR PAAE_ECOLI Name=[2Fe-2S] cluster; Xref=ChEBI CHEBI 49601; Evidence={ECO 0000269|PubMed 21247899}; Note=Binds 1 [2Fe-2S] cluster. {ECO 0000269|PubMed 21247899}; # EcoGene EG13739 paaE # FUNCTION PAAE_ECOLI Component of 1,2-phenylacetyl-CoA epoxidase multicomponent enzyme system which catalyzes the reduction of phenylacetyl-CoA (PA-CoA) to form 1,2-epoxyphenylacetyl-CoA. The subunit E is a reductase with a preference for NADPH and FAD, capable of reducing cytochrome c. {ECO 0000269|PubMed 16997993, ECO 0000269|PubMed 20660314, ECO 0000269|PubMed 21247899, ECO 0000269|PubMed 9748275}. # GO_function GO:0009055 electron carrier activity; IEA:InterPro. # GO_function GO:0016491 oxidoreductase activity; IBA:GO_Central. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0050660 flavin adenine dinucleotide binding; IDA:EcoCyc. # GO_function GO:0051537 2 iron, 2 sulfur cluster binding; IDA:EcoCyc. # GO_function GO:0071949 FAD binding; IBA:GO_Central. # GO_process GO:0010124 phenylacetate catabolic process; IMP:UniProtKB. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.10.20.30 -; 1. # INDUCTION PAAE_ECOLI Activated by cAMP receptor protein (CRP), integration host factor (IHF) and by phenylacetyl-coenzyme A (PA-CoA) that prevents PaaX from binding its target sequences. Inhibited by PaaX. {ECO 0000269|PubMed 10766858, ECO 0000269|PubMed 9748275}. # InterPro IPR001041 2Fe-2S_ferredoxin-type # InterPro IPR001221 Phe_hydroxylase # InterPro IPR001433 OxRdtase_FAD/NAD-bd # InterPro IPR001709 Flavoprot_Pyr_Nucl_cyt_Rdtase # InterPro IPR006058 2Fe2S_fd_BS # InterPro IPR008333 OxRdtase_FAD-bd_dom # InterPro IPR011884 PA_CoA_Oase5 # InterPro IPR012675 Beta-grasp_dom # InterPro IPR017927 Fd_Rdtase_FAD-bd # InterPro IPR017938 Riboflavin_synthase-like_b-brl # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko00360 Phenylalanine metabolism # Organism PAAE_ECOLI Escherichia coli (strain K12) # PATHWAY PAAE_ECOLI Aromatic compound metabolism; phenylacetate degradation. # PATRIC 32118070 VBIEscCol129921_1455 # PIR C64890 C64890 # PRINTS PR00371 FPNCR # PRINTS PR00410 PHEHYDRXLASE # PROSITE PS00197 2FE2S_FER_1 # PROSITE PS51085 2FE2S_FER_2 # PROSITE PS51384 FAD_FR # Pfam PF00111 Fer2 # Pfam PF00175 NAD_binding_1 # Pfam PF00970 FAD_binding_6 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PAAE_ECOLI 1,2-phenylacetyl-CoA epoxidase, subunit E # RefSeq NP_415910 NC_000913.3 # RefSeq WP_000206388 NZ_LN832404.1 # SIMILARITY Contains 1 2Fe-2S ferredoxin-type domain. {ECO:0000255|PROSITE-ProRule PRU00465}. # SIMILARITY Contains 1 FAD-binding FR-type domain. {ECO:0000255|PROSITE-ProRule PRU00716}. # SIMILARITY In the N-terminal section; belongs to the FAD-binding oxidoreductase type 6 family. {ECO 0000305}. # SUPFAM SSF54292 SSF54292 # SUPFAM SSF63380 SSF63380 # TIGRFAMs TIGR02160 PA_CoA_Oxy5 # eggNOG COG1018 LUCA # eggNOG ENOG4105CJJ Bacteria BLAST swissprot:PAAE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PAAE_ECOLI BioCyc ECOL316407:JW1387-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1387-MONOMER BioCyc EcoCyc:G6713-MONOMER http://biocyc.org/getid?id=EcoCyc:G6713-MONOMER BioCyc MetaCyc:G6713-MONOMER http://biocyc.org/getid?id=MetaCyc:G6713-MONOMER COG COG1018 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1018 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.1005399107 http://dx.doi.org/10.1073/pnas.1005399107 DOI 10.1074/jbc.273.40.25974 http://dx.doi.org/10.1074/jbc.273.40.25974 DOI 10.1074/jbc.275.16.12214 http://dx.doi.org/10.1074/jbc.275.16.12214 DOI 10.1074/jbc.M110.194423 http://dx.doi.org/10.1074/jbc.M110.194423 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AEM.01550-06 http://dx.doi.org/10.1128/AEM.01550-06 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X97452 http://www.ebi.ac.uk/ena/data/view/X97452 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- EchoBASE EB3502 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3502 EcoGene EG13739 http://www.ecogene.org/geneInfo.php?eg_id=EG13739 EnsemblBacteria AAC74474 http://www.ensemblgenomes.org/id/AAC74474 EnsemblBacteria AAC74474 http://www.ensemblgenomes.org/id/AAC74474 EnsemblBacteria BAA14998 http://www.ensemblgenomes.org/id/BAA14998 EnsemblBacteria BAA14998 http://www.ensemblgenomes.org/id/BAA14998 EnsemblBacteria BAA14998 http://www.ensemblgenomes.org/id/BAA14998 EnsemblBacteria b1392 http://www.ensemblgenomes.org/id/b1392 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_function GO:0051537 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051537 GO_function GO:0071949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071949 GO_process GO:0010124 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010124 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.10.20.30 http://www.cathdb.info/version/latest/superfamily/3.10.20.30 GeneID 945962 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945962 HOGENOM HOG000141049 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000141049&db=HOGENOM6 InParanoid P76081 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76081 IntAct P76081 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76081* IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR001041 http://www.ebi.ac.uk/interpro/entry/IPR001041 InterPro IPR001221 http://www.ebi.ac.uk/interpro/entry/IPR001221 InterPro IPR001433 http://www.ebi.ac.uk/interpro/entry/IPR001433 InterPro IPR001709 http://www.ebi.ac.uk/interpro/entry/IPR001709 InterPro IPR006058 http://www.ebi.ac.uk/interpro/entry/IPR006058 InterPro IPR008333 http://www.ebi.ac.uk/interpro/entry/IPR008333 InterPro IPR011884 http://www.ebi.ac.uk/interpro/entry/IPR011884 InterPro IPR012675 http://www.ebi.ac.uk/interpro/entry/IPR012675 InterPro IPR017927 http://www.ebi.ac.uk/interpro/entry/IPR017927 InterPro IPR017938 http://www.ebi.ac.uk/interpro/entry/IPR017938 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW1387 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1387 KEGG_Gene eco:b1392 http://www.genome.jp/dbget-bin/www_bget?eco:b1392 KEGG_Orthology KO:K02613 http://www.genome.jp/dbget-bin/www_bget?KO:K02613 KEGG_Pathway ko00360 http://www.genome.jp/kegg-bin/show_pathway?ko00360 KEGG_Reaction rn:R09838 http://www.genome.jp/dbget-bin/www_bget?rn:R09838 OMA YSLEPWE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YSLEPWE PRINTS PR00371 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00371 PRINTS PR00410 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00410 PROSITE PS00197 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00197 PROSITE PS51085 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51085 PROSITE PS51384 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51384 PSORT swissprot:PAAE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PAAE_ECOLI PSORT-B swissprot:PAAE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PAAE_ECOLI PSORT2 swissprot:PAAE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PAAE_ECOLI Pfam PF00111 http://pfam.xfam.org/family/PF00111 Pfam PF00175 http://pfam.xfam.org/family/PF00175 Pfam PF00970 http://pfam.xfam.org/family/PF00970 Phobius swissprot:PAAE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PAAE_ECOLI PhylomeDB P76081 http://phylomedb.org/?seqid=P76081 ProteinModelPortal P76081 http://www.proteinmodelportal.org/query/uniprot/P76081 PubMed 10766858 http://www.ncbi.nlm.nih.gov/pubmed/10766858 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16997993 http://www.ncbi.nlm.nih.gov/pubmed/16997993 PubMed 20660314 http://www.ncbi.nlm.nih.gov/pubmed/20660314 PubMed 21247899 http://www.ncbi.nlm.nih.gov/pubmed/21247899 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9748275 http://www.ncbi.nlm.nih.gov/pubmed/9748275 RefSeq NP_415910 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415910 RefSeq WP_000206388 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000206388 SMR P76081 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76081 STRING 511145.b1392 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1392&targetmode=cogs STRING COG1018 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1018&targetmode=cogs SUPFAM SSF54292 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54292 SUPFAM SSF63380 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63380 TIGRFAMs TIGR02160 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02160 UniProtKB PAAE_ECOLI http://www.uniprot.org/uniprot/PAAE_ECOLI UniProtKB-AC P76081 http://www.uniprot.org/uniprot/P76081 charge swissprot:PAAE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PAAE_ECOLI eggNOG COG1018 http://eggnogapi.embl.de/nog_data/html/tree/COG1018 eggNOG ENOG4105CJJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CJJ epestfind swissprot:PAAE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PAAE_ECOLI garnier swissprot:PAAE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PAAE_ECOLI helixturnhelix swissprot:PAAE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PAAE_ECOLI hmoment swissprot:PAAE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PAAE_ECOLI iep swissprot:PAAE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PAAE_ECOLI inforesidue swissprot:PAAE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PAAE_ECOLI octanol swissprot:PAAE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PAAE_ECOLI pepcoil swissprot:PAAE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PAAE_ECOLI pepdigest swissprot:PAAE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PAAE_ECOLI pepinfo swissprot:PAAE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PAAE_ECOLI pepnet swissprot:PAAE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PAAE_ECOLI pepstats swissprot:PAAE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PAAE_ECOLI pepwheel swissprot:PAAE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PAAE_ECOLI pepwindow swissprot:PAAE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PAAE_ECOLI sigcleave swissprot:PAAE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PAAE_ECOLI ## Database ID URL or Descriptions # AltName THIO2_ECOLI Protein-disulfide reductase # BioGrid 4263420 8 # CATALYTIC ACTIVITY THIO2_ECOLI Protein dithiol + NAD(P)(+) = protein disulfide + NAD(P)H. # EcoGene EG11887 trxC # FUNCTION THIO2_ECOLI Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin. # GO_component GO:0005737 cytoplasm; IMP:EcoCyc. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_function GO:0015035 protein disulfide oxidoreductase activity; IMP:EcoCyc. # GO_function GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor; IBA:GO_Central. # GO_function GO:0047134 protein-disulfide reductase activity; IMP:CACAO. # GO_process GO:0000103 sulfate assimilation; IBA:GO_Central. # GO_process GO:0006457 protein folding; IBA:GO_Central. # GO_process GO:0006662 glycerol ether metabolic process; IEA:InterPro. # GO_process GO:0034599 cellular response to oxidative stress; IBA:GO_Central. # GO_process GO:0045454 cell redox homeostasis; IBA:GO_Central. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006457 protein folding # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0042592 homeostatic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.30.10 -; 1. # IntAct P0AGG4 25 # InterPro IPR005746 Thioredoxin # InterPro IPR012336 Thioredoxin-like_fold # InterPro IPR013766 Thioredoxin_domain # InterPro IPR017937 Thioredoxin_CS # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03110 Chaperones and folding catalysts # Organism THIO2_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10438 PTHR10438 # PATRIC 32120565 VBIEscCol129921_2685 # PIR E65036 E65036 # PROSITE PS00194 THIOREDOXIN_1 # PROSITE PS51352 THIOREDOXIN_2 # Pfam PF00085 Thioredoxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName THIO2_ECOLI Thioredoxin-2 # RefSeq NP_417077 NC_000913.3 # RefSeq WP_001098726 NZ_LN832404.1 # SIMILARITY Belongs to the thioredoxin family. {ECO 0000305}. # SIMILARITY Contains 1 thioredoxin domain. {ECO:0000255|PROSITE- ProRule PRU00691}. # SUBCELLULAR LOCATION THIO2_ECOLI Cytoplasm. # SUPFAM SSF52833 SSF52833 # TIGRFAMs TIGR01068 thioredoxin # eggNOG COG0526 LUCA # eggNOG ENOG4105K63 Bacteria BLAST swissprot:THIO2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:THIO2_ECOLI BioCyc ECOL316407:JW2566-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2566-MONOMER BioCyc EcoCyc:RED-THIOREDOXIN2-MONOMER http://biocyc.org/getid?id=EcoCyc:RED-THIOREDOXIN2-MONOMER BioCyc MetaCyc:RED-THIOREDOXIN2-MONOMER http://biocyc.org/getid?id=MetaCyc:RED-THIOREDOXIN2-MONOMER COG COG0526 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0526 DIP DIP-48115N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48115N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.272.49.30841 http://dx.doi.org/10.1074/jbc.272.49.30841 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.8.1.8 http://www.genome.jp/dbget-bin/www_bget?EC:1.8.1.8 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D13169 http://www.ebi.ac.uk/ena/data/view/D13169 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U85942 http://www.ebi.ac.uk/ena/data/view/U85942 ENZYME 1.8.1.8 http://enzyme.expasy.org/EC/1.8.1.8 EchoBASE EB1833 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1833 EcoGene EG11887 http://www.ecogene.org/geneInfo.php?eg_id=EG11887 EnsemblBacteria AAC75635 http://www.ensemblgenomes.org/id/AAC75635 EnsemblBacteria AAC75635 http://www.ensemblgenomes.org/id/AAC75635 EnsemblBacteria BAA16469 http://www.ensemblgenomes.org/id/BAA16469 EnsemblBacteria BAA16469 http://www.ensemblgenomes.org/id/BAA16469 EnsemblBacteria BAA16469 http://www.ensemblgenomes.org/id/BAA16469 EnsemblBacteria b2582 http://www.ensemblgenomes.org/id/b2582 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0015035 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015035 GO_function GO:0016671 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016671 GO_function GO:0047134 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047134 GO_process GO:0000103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000103 GO_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GO_process GO:0006662 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006662 GO_process GO:0034599 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034599 GO_process GO:0045454 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045454 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.30.10 http://www.cathdb.info/version/latest/superfamily/3.40.30.10 GeneID 947062 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947062 HOGENOM HOG000292979 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000292979&db=HOGENOM6 InParanoid P0AGG4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGG4 IntAct P0AGG4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AGG4* IntEnz 1.8.1.8 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.8.1.8 InterPro IPR005746 http://www.ebi.ac.uk/interpro/entry/IPR005746 InterPro IPR012336 http://www.ebi.ac.uk/interpro/entry/IPR012336 InterPro IPR013766 http://www.ebi.ac.uk/interpro/entry/IPR013766 InterPro IPR017937 http://www.ebi.ac.uk/interpro/entry/IPR017937 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW2566 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2566 KEGG_Gene eco:b2582 http://www.genome.jp/dbget-bin/www_bget?eco:b2582 KEGG_Orthology KO:K03672 http://www.genome.jp/dbget-bin/www_bget?KO:K03672 MINT MINT-1227521 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1227521 OMA QRVDMIN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QRVDMIN PANTHER PTHR10438 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10438 PROSITE PS00194 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00194 PROSITE PS51352 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51352 PSORT swissprot:THIO2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:THIO2_ECOLI PSORT-B swissprot:THIO2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:THIO2_ECOLI PSORT2 swissprot:THIO2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:THIO2_ECOLI Pfam PF00085 http://pfam.xfam.org/family/PF00085 Phobius swissprot:THIO2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:THIO2_ECOLI PhylomeDB P0AGG4 http://phylomedb.org/?seqid=P0AGG4 ProteinModelPortal P0AGG4 http://www.proteinmodelportal.org/query/uniprot/P0AGG4 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9388228 http://www.ncbi.nlm.nih.gov/pubmed/9388228 RefSeq NP_417077 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417077 RefSeq WP_001098726 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001098726 SMR P0AGG4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AGG4 STRING 511145.b2582 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2582&targetmode=cogs STRING COG0526 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0526&targetmode=cogs SUPFAM SSF52833 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52833 TIGRFAMs TIGR01068 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01068 UniProtKB THIO2_ECOLI http://www.uniprot.org/uniprot/THIO2_ECOLI UniProtKB-AC P0AGG4 http://www.uniprot.org/uniprot/P0AGG4 charge swissprot:THIO2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:THIO2_ECOLI eggNOG COG0526 http://eggnogapi.embl.de/nog_data/html/tree/COG0526 eggNOG ENOG4105K63 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K63 epestfind swissprot:THIO2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:THIO2_ECOLI garnier swissprot:THIO2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:THIO2_ECOLI helixturnhelix swissprot:THIO2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:THIO2_ECOLI hmoment swissprot:THIO2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:THIO2_ECOLI iep swissprot:THIO2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:THIO2_ECOLI inforesidue swissprot:THIO2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:THIO2_ECOLI octanol swissprot:THIO2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:THIO2_ECOLI pepcoil swissprot:THIO2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:THIO2_ECOLI pepdigest swissprot:THIO2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:THIO2_ECOLI pepinfo swissprot:THIO2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:THIO2_ECOLI pepnet swissprot:THIO2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:THIO2_ECOLI pepstats swissprot:THIO2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:THIO2_ECOLI pepwheel swissprot:THIO2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:THIO2_ECOLI pepwindow swissprot:THIO2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:THIO2_ECOLI sigcleave swissprot:THIO2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:THIO2_ECOLI ## Database ID URL or Descriptions # BioGrid 4261428 8 # EcoGene EG10483 hypA # FUNCTION HYPA_ECOLI Not required for the formation of hydrogenases 1 and 2. Plays probably a regulatory role. # GO_component GO:0031234 extrinsic component of cytoplasmic side of plasma membrane; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_function GO:0016151 nickel cation binding; IDA:EcoCyc. # GO_process GO:0006464 cellular protein modification process; IEA:UniProtKB-HAMAP. # GO_process GO:0051604 protein maturation; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0051604 protein maturation # HAMAP MF_00213 HypA # INTERACTION HYPA_ECOLI P16431 hycE; NbExp=14; IntAct=EBI-6290024, EBI-552702; # IntAct P0A700 9 # InterPro IPR000688 Hydgase_Ni_incorp_HypA/HybF # InterPro IPR020538 Hydgase_Ni_incorp_HypA/HybF_CS # Organism HYPA_ECOLI Escherichia coli (strain K12) # PATRIC 32120852 VBIEscCol129921_2818 # PIR S15197 S15197 # PIRSF PIRSF004761 Hydrgn_mat_HypA # PROSITE PS01249 HYPA # Pfam PF01155 HypA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HYPA_ECOLI Protein HypA # RefSeq NP_417206 NC_000913.3 # RefSeq WP_001299100 NZ_LN832404.1 # SIMILARITY Belongs to the HypA/HybF family. {ECO 0000305}. # TIGRFAMs TIGR00100 hypA # eggNOG COG0375 LUCA # eggNOG ENOG410816D Bacteria BLAST swissprot:HYPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HYPA_ECOLI BioCyc ECOL316407:JW2696-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2696-MONOMER BioCyc EcoCyc:EG10483-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10483-MONOMER BioCyc MetaCyc:EG10483-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10483-MONOMER COG COG0375 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0375 DIP DIP-48022N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48022N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1991.tb01833.x http://dx.doi.org/10.1111/j.1365-2958.1991.tb01833.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EMBL X54543 http://www.ebi.ac.uk/ena/data/view/X54543 EchoBASE EB0478 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0478 EcoGene EG10483 http://www.ecogene.org/geneInfo.php?eg_id=EG10483 EnsemblBacteria AAC75768 http://www.ensemblgenomes.org/id/AAC75768 EnsemblBacteria AAC75768 http://www.ensemblgenomes.org/id/AAC75768 EnsemblBacteria BAE76803 http://www.ensemblgenomes.org/id/BAE76803 EnsemblBacteria BAE76803 http://www.ensemblgenomes.org/id/BAE76803 EnsemblBacteria BAE76803 http://www.ensemblgenomes.org/id/BAE76803 EnsemblBacteria b2726 http://www.ensemblgenomes.org/id/b2726 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0031234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031234 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0016151 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016151 GO_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GO_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 GeneID 947195 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947195 HAMAP MF_00213 http://hamap.expasy.org/unirule/MF_00213 HOGENOM HOG000291317 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000291317&db=HOGENOM6 InParanoid P0A700 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A700 IntAct P0A700 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A700* InterPro IPR000688 http://www.ebi.ac.uk/interpro/entry/IPR000688 InterPro IPR020538 http://www.ebi.ac.uk/interpro/entry/IPR020538 KEGG_Gene ecj:JW2696 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2696 KEGG_Gene eco:b2726 http://www.genome.jp/dbget-bin/www_bget?eco:b2726 KEGG_Orthology KO:K04651 http://www.genome.jp/dbget-bin/www_bget?KO:K04651 OMA EEQQAEC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EEQQAEC PROSITE PS01249 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01249 PSORT swissprot:HYPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HYPA_ECOLI PSORT-B swissprot:HYPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HYPA_ECOLI PSORT2 swissprot:HYPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HYPA_ECOLI Pfam PF01155 http://pfam.xfam.org/family/PF01155 Phobius swissprot:HYPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HYPA_ECOLI PhylomeDB P0A700 http://phylomedb.org/?seqid=P0A700 ProteinModelPortal P0A700 http://www.proteinmodelportal.org/query/uniprot/P0A700 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1849603 http://www.ncbi.nlm.nih.gov/pubmed/1849603 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417206 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417206 RefSeq WP_001299100 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001299100 SMR P0A700 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A700 STRING 511145.b2726 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2726&targetmode=cogs STRING COG0375 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0375&targetmode=cogs TIGRFAMs TIGR00100 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00100 UniProtKB HYPA_ECOLI http://www.uniprot.org/uniprot/HYPA_ECOLI UniProtKB-AC P0A700 http://www.uniprot.org/uniprot/P0A700 charge swissprot:HYPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HYPA_ECOLI eggNOG COG0375 http://eggnogapi.embl.de/nog_data/html/tree/COG0375 eggNOG ENOG410816D http://eggnogapi.embl.de/nog_data/html/tree/ENOG410816D epestfind swissprot:HYPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HYPA_ECOLI garnier swissprot:HYPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HYPA_ECOLI helixturnhelix swissprot:HYPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HYPA_ECOLI hmoment swissprot:HYPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HYPA_ECOLI iep swissprot:HYPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HYPA_ECOLI inforesidue swissprot:HYPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HYPA_ECOLI octanol swissprot:HYPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HYPA_ECOLI pepcoil swissprot:HYPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HYPA_ECOLI pepdigest swissprot:HYPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HYPA_ECOLI pepinfo swissprot:HYPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HYPA_ECOLI pepnet swissprot:HYPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HYPA_ECOLI pepstats swissprot:HYPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HYPA_ECOLI pepwheel swissprot:HYPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HYPA_ECOLI pepwindow swissprot:HYPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HYPA_ECOLI sigcleave swissprot:HYPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HYPA_ECOLI ## Database ID URL or Descriptions # BioGrid 4263285 12 # EcoGene EG13361 ydaS # GO_function GO:0003677 DNA binding; IEA:InterPro. # GOslim_function GO:0003677 DNA binding # Gene3D 1.10.260.40 -; 1. # IntAct P76063 2 # InterPro IPR010982 Lambda_DNA-bd_dom # InterPro IPR031856 YdaS_antitoxin # Organism YDAS_ECOLI Escherichia coli (strain K12) # PIR H64885 H64885 # Pfam PF15943 YdaS_antitoxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDAS_ECOLI Uncharacterized protein YdaS # RefSeq NP_415875 NC_000913.3 # RefSeq WP_000712069 NZ_CP014272.1 # SUPFAM SSF47413 SSF47413 # eggNOG COG4197 LUCA # eggNOG ENOG4105W7J Bacteria BLAST swissprot:YDAS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDAS_ECOLI BioCyc ECOL316407:JW1352-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1352-MONOMER BioCyc EcoCyc:G6681-MONOMER http://biocyc.org/getid?id=EcoCyc:G6681-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3144 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3144 EcoGene EG13361 http://www.ecogene.org/geneInfo.php?eg_id=EG13361 EnsemblBacteria AAC74439 http://www.ensemblgenomes.org/id/AAC74439 EnsemblBacteria AAC74439 http://www.ensemblgenomes.org/id/AAC74439 EnsemblBacteria BAE76412 http://www.ensemblgenomes.org/id/BAE76412 EnsemblBacteria BAE76412 http://www.ensemblgenomes.org/id/BAE76412 EnsemblBacteria BAE76412 http://www.ensemblgenomes.org/id/BAE76412 EnsemblBacteria b1357 http://www.ensemblgenomes.org/id/b1357 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 Gene3D 1.10.260.40 http://www.cathdb.info/version/latest/superfamily/1.10.260.40 GeneID 945923 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945923 HOGENOM HOG000219513 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219513&db=HOGENOM6 IntAct P76063 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76063* InterPro IPR010982 http://www.ebi.ac.uk/interpro/entry/IPR010982 InterPro IPR031856 http://www.ebi.ac.uk/interpro/entry/IPR031856 KEGG_Gene ecj:JW1352 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1352 KEGG_Gene eco:b1357 http://www.genome.jp/dbget-bin/www_bget?eco:b1357 OMA RIDASAC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RIDASAC PSORT swissprot:YDAS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDAS_ECOLI PSORT-B swissprot:YDAS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDAS_ECOLI PSORT2 swissprot:YDAS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDAS_ECOLI Pfam PF15943 http://pfam.xfam.org/family/PF15943 Phobius swissprot:YDAS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDAS_ECOLI ProteinModelPortal P76063 http://www.proteinmodelportal.org/query/uniprot/P76063 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415875 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415875 RefSeq WP_000712069 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000712069 SMR P76063 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76063 STRING 511145.b1357 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1357&targetmode=cogs SUPFAM SSF47413 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47413 UniProtKB YDAS_ECOLI http://www.uniprot.org/uniprot/YDAS_ECOLI UniProtKB-AC P76063 http://www.uniprot.org/uniprot/P76063 charge swissprot:YDAS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDAS_ECOLI eggNOG COG4197 http://eggnogapi.embl.de/nog_data/html/tree/COG4197 eggNOG ENOG4105W7J http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105W7J epestfind swissprot:YDAS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDAS_ECOLI garnier swissprot:YDAS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDAS_ECOLI helixturnhelix swissprot:YDAS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDAS_ECOLI hmoment swissprot:YDAS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDAS_ECOLI iep swissprot:YDAS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDAS_ECOLI inforesidue swissprot:YDAS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDAS_ECOLI octanol swissprot:YDAS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDAS_ECOLI pepcoil swissprot:YDAS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDAS_ECOLI pepdigest swissprot:YDAS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDAS_ECOLI pepinfo swissprot:YDAS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDAS_ECOLI pepnet swissprot:YDAS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDAS_ECOLI pepstats swissprot:YDAS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDAS_ECOLI pepwheel swissprot:YDAS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDAS_ECOLI pepwindow swissprot:YDAS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDAS_ECOLI sigcleave swissprot:YDAS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDAS_ECOLI ## Database ID URL or Descriptions # BioGrid 4262573 204 # EcoGene EG11350 rfaS # GO_process GO:0009244 lipopolysaccharide core region biosynthetic process; IMP:EcoCyc. # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # IntAct P27126 3 # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01003 Glycosyltransferases # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # Organism RFAS_ECOLI Escherichia coli (strain K12) # PATHWAY RFAS_ECOLI Bacterial outer membrane biogenesis; LPS core biosynthesis. # PATRIC 32122745 VBIEscCol129921_3749 # PIR A42982 A42982 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RFAS_ECOLI Lipopolysaccharide core biosynthesis protein RfaS # RefSeq NP_418086 NC_000913.3 # RefSeq WP_000158225 NZ_LN832404.1 # eggNOG ENOG410650X Bacteria # eggNOG ENOG4112C48 LUCA BLAST swissprot:RFAS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RFAS_ECOLI BioCyc ECOL316407:JW3604-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3604-MONOMER BioCyc EcoCyc:EG11350-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11350-MONOMER COG CAZy: http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=CAZy: COG GT8 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=GT8 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M80599 http://www.ebi.ac.uk/ena/data/view/M80599 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1325 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1325 EcoGene EG11350 http://www.ecogene.org/geneInfo.php?eg_id=EG11350 EnsemblBacteria AAC76653 http://www.ensemblgenomes.org/id/AAC76653 EnsemblBacteria AAC76653 http://www.ensemblgenomes.org/id/AAC76653 EnsemblBacteria BAE77663 http://www.ensemblgenomes.org/id/BAE77663 EnsemblBacteria BAE77663 http://www.ensemblgenomes.org/id/BAE77663 EnsemblBacteria BAE77663 http://www.ensemblgenomes.org/id/BAE77663 EnsemblBacteria b3629 http://www.ensemblgenomes.org/id/b3629 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0009244 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009244 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 948151 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948151 HOGENOM HOG000054847 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000054847&db=HOGENOM6 IntAct P27126 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P27126* KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01003 http://www.genome.jp/dbget-bin/www_bget?ko01003 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Gene ecj:JW3604 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3604 KEGG_Gene eco:b3629 http://www.genome.jp/dbget-bin/www_bget?eco:b3629 KEGG_Orthology KO:K12986 http://www.genome.jp/dbget-bin/www_bget?KO:K12986 OMA WNSEYER http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WNSEYER PSORT swissprot:RFAS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RFAS_ECOLI PSORT-B swissprot:RFAS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RFAS_ECOLI PSORT2 swissprot:RFAS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RFAS_ECOLI Phobius swissprot:RFAS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RFAS_ECOLI ProteinModelPortal P27126 http://www.proteinmodelportal.org/query/uniprot/P27126 PubMed 1624461 http://www.ncbi.nlm.nih.gov/pubmed/1624461 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418086 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418086 RefSeq WP_000158225 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000158225 STRING 511145.b3629 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3629&targetmode=cogs STRING CAZy: http://string-db.org/newstring_cgi/show_network_section.pl?identifier=CAZy:&targetmode=cogs STRING GT8 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=GT8&targetmode=cogs UniProtKB RFAS_ECOLI http://www.uniprot.org/uniprot/RFAS_ECOLI UniProtKB-AC P27126 http://www.uniprot.org/uniprot/P27126 charge swissprot:RFAS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RFAS_ECOLI eggNOG ENOG410650X http://eggnogapi.embl.de/nog_data/html/tree/ENOG410650X eggNOG ENOG4112C48 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4112C48 epestfind swissprot:RFAS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RFAS_ECOLI garnier swissprot:RFAS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RFAS_ECOLI helixturnhelix swissprot:RFAS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RFAS_ECOLI hmoment swissprot:RFAS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RFAS_ECOLI iep swissprot:RFAS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RFAS_ECOLI inforesidue swissprot:RFAS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RFAS_ECOLI octanol swissprot:RFAS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RFAS_ECOLI pepcoil swissprot:RFAS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RFAS_ECOLI pepdigest swissprot:RFAS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RFAS_ECOLI pepinfo swissprot:RFAS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RFAS_ECOLI pepnet swissprot:RFAS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RFAS_ECOLI pepstats swissprot:RFAS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RFAS_ECOLI pepwheel swissprot:RFAS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RFAS_ECOLI pepwindow swissprot:RFAS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RFAS_ECOLI sigcleave swissprot:RFAS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RFAS_ECOLI ## Database ID URL or Descriptions # BioGrid 4261540 197 # EcoGene EG10828 recF # FUNCTION RECF_ECOLI The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003697 single-stranded DNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_process GO:0000731 DNA synthesis involved in DNA repair; IMP:EcoliWiki. # GO_process GO:0006260 DNA replication; IEA:UniProtKB-HAMAP. # GO_process GO:0006302 double-strand break repair; IBA:GO_Central. # GO_process GO:0009411 response to UV; IMP:EcoliWiki. # GO_process GO:0009432 SOS response; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.300 -; 2. # HAMAP MF_00365 RecF # INTERACTION RECF_ECOLI P0A6F5 groL; NbExp=3; IntAct=EBI-556839, EBI-543750; # IntAct P0A7H0 13 # InterPro IPR001238 DNA-binding_RecF # InterPro IPR003395 RecF/RecN/SMC_N # InterPro IPR018078 DNA-binding_RecF_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko03440 Homologous recombination # Organism RECF_ECOLI Escherichia coli (strain K12) # PANTHER PTHR32182:SF0 PTHR32182:SF0 # PATRIC 32122897 VBIEscCol129921_3824 # PIR A03547 RQECF # PROSITE PS00617 RECF_1 # PROSITE PS00618 RECF_2 # Pfam PF02463 SMC_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RECF_ECOLI DNA replication and repair protein RecF # RefSeq NP_418155 NC_000913.3 # RefSeq WP_000060112 NZ_LN832404.1 # SIMILARITY Belongs to the RecF family. {ECO 0000305}. # SUBCELLULAR LOCATION RECF_ECOLI Cytoplasm {ECO 0000250}. # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR00611 recf # eggNOG COG1195 LUCA # eggNOG ENOG4105C3X Bacteria BLAST swissprot:RECF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RECF_ECOLI BioCyc ECOL316407:JW3677-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3677-MONOMER BioCyc EcoCyc:EG10828-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10828-MONOMER BioCyc MetaCyc:EG10828-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10828-MONOMER COG COG1195 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1195 DIP DIP-36037N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36037N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.81.15.4622 http://dx.doi.org/10.1073/pnas.81.15.4622 DOI 10.1093/nar/12.16.6389 http://dx.doi.org/10.1093/nar/12.16.6389 DOI 10.1093/nar/20.4.839 http://dx.doi.org/10.1093/nar/20.4.839 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K02179 http://www.ebi.ac.uk/ena/data/view/K02179 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X04341 http://www.ebi.ac.uk/ena/data/view/X04341 EchoBASE EB0821 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0821 EcoGene EG10828 http://www.ecogene.org/geneInfo.php?eg_id=EG10828 EnsemblBacteria AAC76723 http://www.ensemblgenomes.org/id/AAC76723 EnsemblBacteria AAC76723 http://www.ensemblgenomes.org/id/AAC76723 EnsemblBacteria BAE77594 http://www.ensemblgenomes.org/id/BAE77594 EnsemblBacteria BAE77594 http://www.ensemblgenomes.org/id/BAE77594 EnsemblBacteria BAE77594 http://www.ensemblgenomes.org/id/BAE77594 EnsemblBacteria b3700 http://www.ensemblgenomes.org/id/b3700 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003697 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003697 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0000731 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000731 GO_process GO:0006260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260 GO_process GO:0006302 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006302 GO_process GO:0009411 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009411 GO_process GO:0009432 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009432 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948209 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948209 HAMAP MF_00365 http://hamap.expasy.org/unirule/MF_00365 HOGENOM HOG000269560 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000269560&db=HOGENOM6 InParanoid P0A7H0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7H0 IntAct P0A7H0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7H0* InterPro IPR001238 http://www.ebi.ac.uk/interpro/entry/IPR001238 InterPro IPR003395 http://www.ebi.ac.uk/interpro/entry/IPR003395 InterPro IPR018078 http://www.ebi.ac.uk/interpro/entry/IPR018078 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW3677 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3677 KEGG_Gene eco:b3700 http://www.genome.jp/dbget-bin/www_bget?eco:b3700 KEGG_Orthology KO:K03629 http://www.genome.jp/dbget-bin/www_bget?KO:K03629 KEGG_Pathway ko03440 http://www.genome.jp/kegg-bin/show_pathway?ko03440 MINT MINT-1291712 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1291712 OMA KVQTFIT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KVQTFIT PANTHER PTHR32182:SF0 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32182:SF0 PROSITE PS00617 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00617 PROSITE PS00618 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00618 PSORT swissprot:RECF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RECF_ECOLI PSORT-B swissprot:RECF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RECF_ECOLI PSORT2 swissprot:RECF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RECF_ECOLI Pfam PF02463 http://pfam.xfam.org/family/PF02463 Phobius swissprot:RECF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RECF_ECOLI PhylomeDB P0A7H0 http://phylomedb.org/?seqid=P0A7H0 ProteinModelPortal P0A7H0 http://www.proteinmodelportal.org/query/uniprot/P0A7H0 PubMed 1542576 http://www.ncbi.nlm.nih.gov/pubmed/1542576 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2228960 http://www.ncbi.nlm.nih.gov/pubmed/2228960 PubMed 6089112 http://www.ncbi.nlm.nih.gov/pubmed/6089112 PubMed 6379647 http://www.ncbi.nlm.nih.gov/pubmed/6379647 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418155 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418155 RefSeq WP_000060112 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000060112 SMR P0A7H0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7H0 STRING 511145.b3700 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3700&targetmode=cogs STRING COG1195 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1195&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR00611 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00611 UniProtKB RECF_ECOLI http://www.uniprot.org/uniprot/RECF_ECOLI UniProtKB-AC P0A7H0 http://www.uniprot.org/uniprot/P0A7H0 charge swissprot:RECF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RECF_ECOLI eggNOG COG1195 http://eggnogapi.embl.de/nog_data/html/tree/COG1195 eggNOG ENOG4105C3X http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C3X epestfind swissprot:RECF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RECF_ECOLI garnier swissprot:RECF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RECF_ECOLI helixturnhelix swissprot:RECF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RECF_ECOLI hmoment swissprot:RECF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RECF_ECOLI iep swissprot:RECF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RECF_ECOLI inforesidue swissprot:RECF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RECF_ECOLI octanol swissprot:RECF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RECF_ECOLI pepcoil swissprot:RECF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RECF_ECOLI pepdigest swissprot:RECF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RECF_ECOLI pepinfo swissprot:RECF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RECF_ECOLI pepnet swissprot:RECF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RECF_ECOLI pepstats swissprot:RECF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RECF_ECOLI pepwheel swissprot:RECF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RECF_ECOLI pepwindow swissprot:RECF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RECF_ECOLI sigcleave swissprot:RECF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RECF_ECOLI ## Database ID URL or Descriptions # BioGrid 4262785 113 # CATALYTIC ACTIVITY HOLD_ECOLI Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). # EcoGene EG11414 holD # FUNCTION HOLD_ECOLI DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown. # GO_function GO:0003887 DNA-directed DNA polymerase activity; IEA:UniProtKB-KW. # GO_function GO:0008408 3'-5' exonuclease activity; IEA:InterPro. # GO_process GO:0006260 DNA replication; IEA:UniProtKB-KW. # GOslim_function GO:0004518 nuclease activity # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.10220 -; 1. # INTERACTION HOLD_ECOLI P06710 dnaX; NbExp=18; IntAct=EBI-549176, EBI-549140; P06710-2 dnaX; NbExp=2; IntAct=EBI-549176, EBI-2604194; P28905 holC; NbExp=22; IntAct=EBI-549176, EBI-549169; # IntAct P28632 22 # InterPro IPR004615 DNA_pol_III_psi # InterPro IPR018382 DNA_pol_III_psi_subgr # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03032 DNA replication proteins # KEGG_Brite ko03032 M00260 DNA polymerase III complex, bacteria # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Brite ko03400 M00260 DNA polymerase III complex, bacteria # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00240 Pyrimidine metabolism # KEGG_Pathway ko03030 DNA replication # KEGG_Pathway ko03430 Mismatch repair # KEGG_Pathway ko03440 Homologous recombination # Organism HOLD_ECOLI Escherichia coli (strain K12) # PATRIC 32124354 VBIEscCol129921_4517 # PDB 1EM8 X-ray; 2.10 A; B/D=26-137 # PDB 3GLI X-ray; 3.50 A; O/P=2-28 # PDB 3SXU X-ray; 1.85 A; B=2-137 # PIR A48647 A48647 # PIRSF PIRSF029225 DNA_pol_III_psi # Pfam PF03603 DNA_III_psi # ProDom PD032475 DNA_pol_III_psi # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HOLD_ECOLI DNA polymerase III subunit psi # RefSeq NP_418789 NC_000913.3 # RefSeq WP_000204012 NZ_LN832404.1 # SUBUNIT The DNA polymerase holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential subassemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core (subunits alpha,epsilon and theta) contains the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork. This complex contains delta, delta', psi and chi, and copies of either or both of two different DnaX proteins, gamma and tau. The composition of the holoenzyme is, therefore (alpha,epsilon,theta)[2]-(gamma/tau)[3]-delta,delta', psi,chi- beta[4]. # SUPFAM SSF102220 SSF102220 # TIGRFAMs TIGR00664 DNA_III_psi # eggNOG COG3050 LUCA # eggNOG ENOG4108WPU Bacteria BLAST swissprot:HOLD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HOLD_ECOLI BioCyc ECOL316407:JW4334-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4334-MONOMER BioCyc EcoCyc:EG11414-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11414-MONOMER BioCyc MetaCyc:EG11414-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11414-MONOMER COG COG3050 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3050 DIP DIP-9934N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9934N DOI 10.1002/bies.950140206 http://dx.doi.org/10.1002/bies.950140206 DOI 10.1007/BF00331153 http://dx.doi.org/10.1007/BF00331153 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1432-1033.2003.03944.x http://dx.doi.org/10.1046/j.1432-1033.2003.03944.x DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.7.7 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.7 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L04575 http://www.ebi.ac.uk/ena/data/view/L04575 EMBL L05387 http://www.ebi.ac.uk/ena/data/view/L05387 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X06117 http://www.ebi.ac.uk/ena/data/view/X06117 ENZYME 2.7.7.7 http://enzyme.expasy.org/EC/2.7.7.7 EchoBASE EB1386 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1386 EcoGene EG11414 http://www.ecogene.org/geneInfo.php?eg_id=EG11414 EnsemblBacteria AAC77325 http://www.ensemblgenomes.org/id/AAC77325 EnsemblBacteria AAC77325 http://www.ensemblgenomes.org/id/AAC77325 EnsemblBacteria BAE78360 http://www.ensemblgenomes.org/id/BAE78360 EnsemblBacteria BAE78360 http://www.ensemblgenomes.org/id/BAE78360 EnsemblBacteria BAE78360 http://www.ensemblgenomes.org/id/BAE78360 EnsemblBacteria b4372 http://www.ensemblgenomes.org/id/b4372 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003887 GO_function GO:0008408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008408 GO_process GO:0006260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.10220 http://www.cathdb.info/version/latest/superfamily/3.40.50.10220 GeneID 948890 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948890 HOGENOM HOG000218328 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218328&db=HOGENOM6 IntAct P28632 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P28632* IntEnz 2.7.7.7 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.7 InterPro IPR004615 http://www.ebi.ac.uk/interpro/entry/IPR004615 InterPro IPR018382 http://www.ebi.ac.uk/interpro/entry/IPR018382 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03032 http://www.genome.jp/dbget-bin/www_bget?ko03032 KEGG_Brite ko03032 http://www.genome.jp/dbget-bin/www_bget?ko03032 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW4334 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4334 KEGG_Gene eco:b4372 http://www.genome.jp/dbget-bin/www_bget?eco:b4372 KEGG_Orthology KO:K02344 http://www.genome.jp/dbget-bin/www_bget?KO:K02344 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Pathway ko03030 http://www.genome.jp/kegg-bin/show_pathway?ko03030 KEGG_Pathway ko03430 http://www.genome.jp/kegg-bin/show_pathway?ko03430 KEGG_Pathway ko03440 http://www.genome.jp/kegg-bin/show_pathway?ko03440 KEGG_Reaction rn:R00375 http://www.genome.jp/dbget-bin/www_bget?rn:R00375 KEGG_Reaction rn:R00376 http://www.genome.jp/dbget-bin/www_bget?rn:R00376 KEGG_Reaction rn:R00377 http://www.genome.jp/dbget-bin/www_bget?rn:R00377 KEGG_Reaction rn:R00378 http://www.genome.jp/dbget-bin/www_bget?rn:R00378 MINT MINT-1224283 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1224283 OMA QICAHEH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QICAHEH PDB 1EM8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1EM8 PDB 3GLI http://www.ebi.ac.uk/pdbe-srv/view/entry/3GLI PDB 3SXU http://www.ebi.ac.uk/pdbe-srv/view/entry/3SXU PDBsum 1EM8 http://www.ebi.ac.uk/pdbsum/1EM8 PDBsum 3GLI http://www.ebi.ac.uk/pdbsum/3GLI PDBsum 3SXU http://www.ebi.ac.uk/pdbsum/3SXU PSORT swissprot:HOLD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HOLD_ECOLI PSORT-B swissprot:HOLD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HOLD_ECOLI PSORT2 swissprot:HOLD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HOLD_ECOLI Pfam PF03603 http://pfam.xfam.org/family/PF03603 Phobius swissprot:HOLD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HOLD_ECOLI ProteinModelPortal P28632 http://www.proteinmodelportal.org/query/uniprot/P28632 PubMed 14717711 http://www.ncbi.nlm.nih.gov/pubmed/14717711 PubMed 1575709 http://www.ncbi.nlm.nih.gov/pubmed/1575709 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2828880 http://www.ncbi.nlm.nih.gov/pubmed/2828880 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8366044 http://www.ncbi.nlm.nih.gov/pubmed/8366044 PubMed 8389364 http://www.ncbi.nlm.nih.gov/pubmed/8389364 PubMed 8505305 http://www.ncbi.nlm.nih.gov/pubmed/8505305 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418789 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418789 RefSeq WP_000204012 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000204012 SMR P28632 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P28632 STRING 511145.b4372 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4372&targetmode=cogs STRING COG3050 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3050&targetmode=cogs SUPFAM SSF102220 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF102220 TIGRFAMs TIGR00664 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00664 UniProtKB HOLD_ECOLI http://www.uniprot.org/uniprot/HOLD_ECOLI UniProtKB-AC P28632 http://www.uniprot.org/uniprot/P28632 charge swissprot:HOLD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HOLD_ECOLI eggNOG COG3050 http://eggnogapi.embl.de/nog_data/html/tree/COG3050 eggNOG ENOG4108WPU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108WPU epestfind swissprot:HOLD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HOLD_ECOLI garnier swissprot:HOLD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HOLD_ECOLI helixturnhelix swissprot:HOLD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HOLD_ECOLI hmoment swissprot:HOLD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HOLD_ECOLI iep swissprot:HOLD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HOLD_ECOLI inforesidue swissprot:HOLD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HOLD_ECOLI octanol swissprot:HOLD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HOLD_ECOLI pepcoil swissprot:HOLD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HOLD_ECOLI pepdigest swissprot:HOLD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HOLD_ECOLI pepinfo swissprot:HOLD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HOLD_ECOLI pepnet swissprot:HOLD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HOLD_ECOLI pepstats swissprot:HOLD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HOLD_ECOLI pepwheel swissprot:HOLD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HOLD_ECOLI pepwindow swissprot:HOLD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HOLD_ECOLI sigcleave swissprot:HOLD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HOLD_ECOLI ## Database ID URL or Descriptions # AltName GTRB_ECOLI Bactoprenol glucosyl transferase homolog from prophage CPS-53 # BioGrid 4260542 166 # CAZy GT2 Glycosyltransferase Family 2 # EcoGene EG14132 yfdH # FUNCTION GTRB_ECOLI Involved in O antigen modification. Catalyzes the transfer of the glucose residue from UDP-glucose to a lipid carrier (By similarity). {ECO 0000250}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0016740 transferase activity; IBA:GO_Central. # GO_function GO:0016757 transferase activity, transferring glycosyl groups; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # Gene3D 3.90.550.10 -; 1. # InterPro IPR001173 Glyco_trans_2-like # InterPro IPR029044 Nucleotide-diphossugar_trans # Organism GTRB_ECOLI Escherichia coli (strain K12) # PATRIC 32120075 VBIEscCol129921_2446 # PIR D65008 D65008 # Pfam PF00535 Glycos_transf_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Prophage bactoprenol glucosyl transferase homolog {ECO 0000305} # RefSeq NP_416852 NC_000913.3 # RefSeq WP_000703651 NZ_LN832404.1 # SIMILARITY Belongs to the glycosyltransferase 2 family. GtrB subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION GTRB_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF53448 SSF53448 # eggNOG COG0463 LUCA # eggNOG ENOG4105CKK Bacteria BLAST swissprot:GTRB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GTRB_ECOLI BioCyc ECOL316407:JW2347-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2347-MONOMER BioCyc EcoCyc:G7220-MONOMER http://biocyc.org/getid?id=EcoCyc:G7220-MONOMER DIP DIP-11997N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11997N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.4.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.4.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.4.1.- http://enzyme.expasy.org/EC/2.4.1.- EchoBASE EB3884 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3884 EcoGene EG14132 http://www.ecogene.org/geneInfo.php?eg_id=EG14132 EnsemblBacteria AAC75410 http://www.ensemblgenomes.org/id/AAC75410 EnsemblBacteria AAC75410 http://www.ensemblgenomes.org/id/AAC75410 EnsemblBacteria BAA16210 http://www.ensemblgenomes.org/id/BAA16210 EnsemblBacteria BAA16210 http://www.ensemblgenomes.org/id/BAA16210 EnsemblBacteria BAA16210 http://www.ensemblgenomes.org/id/BAA16210 EnsemblBacteria b2351 http://www.ensemblgenomes.org/id/b2351 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0016740 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016740 GO_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 Gene3D 3.90.550.10 http://www.cathdb.info/version/latest/superfamily/3.90.550.10 GeneID 949098 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949098 HOGENOM HOG000283247 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000283247&db=HOGENOM6 InParanoid P77293 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77293 IntAct P77293 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77293* IntEnz 2.4.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.1 InterPro IPR001173 http://www.ebi.ac.uk/interpro/entry/IPR001173 InterPro IPR029044 http://www.ebi.ac.uk/interpro/entry/IPR029044 KEGG_Gene ecj:JW2347 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2347 KEGG_Gene eco:b2351 http://www.genome.jp/dbget-bin/www_bget?eco:b2351 OMA KLWNFAI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KLWNFAI PSORT swissprot:GTRB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GTRB_ECOLI PSORT-B swissprot:GTRB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GTRB_ECOLI PSORT2 swissprot:GTRB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GTRB_ECOLI Pfam PF00535 http://pfam.xfam.org/family/PF00535 Phobius swissprot:GTRB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GTRB_ECOLI PhylomeDB P77293 http://phylomedb.org/?seqid=P77293 ProteinModelPortal P77293 http://www.proteinmodelportal.org/query/uniprot/P77293 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416852 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416852 RefSeq WP_000703651 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000703651 SMR P77293 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77293 STRING 511145.b2351 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2351&targetmode=cogs SUPFAM SSF53448 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53448 UniProtKB GTRB_ECOLI http://www.uniprot.org/uniprot/GTRB_ECOLI UniProtKB-AC P77293 http://www.uniprot.org/uniprot/P77293 charge swissprot:GTRB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GTRB_ECOLI eggNOG COG0463 http://eggnogapi.embl.de/nog_data/html/tree/COG0463 eggNOG ENOG4105CKK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CKK epestfind swissprot:GTRB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GTRB_ECOLI garnier swissprot:GTRB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GTRB_ECOLI helixturnhelix swissprot:GTRB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GTRB_ECOLI hmoment swissprot:GTRB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GTRB_ECOLI iep swissprot:GTRB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GTRB_ECOLI inforesidue swissprot:GTRB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GTRB_ECOLI octanol swissprot:GTRB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GTRB_ECOLI pepcoil swissprot:GTRB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GTRB_ECOLI pepdigest swissprot:GTRB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GTRB_ECOLI pepinfo swissprot:GTRB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GTRB_ECOLI pepnet swissprot:GTRB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GTRB_ECOLI pepstats swissprot:GTRB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GTRB_ECOLI pepwheel swissprot:GTRB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GTRB_ECOLI pepwindow swissprot:GTRB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GTRB_ECOLI sigcleave swissprot:GTRB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GTRB_ECOLI ## Database ID URL or Descriptions # BioGrid 4261136 8 # EcoGene EG12201 ygaC # IntAct P0AD53 4 # InterPro IPR018994 DUF2002 # Organism YGAC_ECOLI Escherichia coli (strain K12) # PATRIC 32120732 VBIEscCol129921_2763 # PIR H65046 H65046 # Pfam PF09400 DUF2002 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGAC_ECOLI Uncharacterized protein YgaC # RefSeq NP_417157 NC_000913.3 # RefSeq WP_000281320 NZ_LN832404.1 # eggNOG ENOG4108WMJ Bacteria # eggNOG ENOG4111KTT LUCA BLAST swissprot:YGAC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGAC_ECOLI BioCyc ECOL316407:JW2646-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2646-MONOMER BioCyc EcoCyc:EG12201-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12201-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U07823 http://www.ebi.ac.uk/ena/data/view/U07823 EchoBASE EB2117 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2117 EcoGene EG12201 http://www.ecogene.org/geneInfo.php?eg_id=EG12201 EnsemblBacteria AAC75718 http://www.ensemblgenomes.org/id/AAC75718 EnsemblBacteria AAC75718 http://www.ensemblgenomes.org/id/AAC75718 EnsemblBacteria BAA16536 http://www.ensemblgenomes.org/id/BAA16536 EnsemblBacteria BAA16536 http://www.ensemblgenomes.org/id/BAA16536 EnsemblBacteria BAA16536 http://www.ensemblgenomes.org/id/BAA16536 EnsemblBacteria b2671 http://www.ensemblgenomes.org/id/b2671 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947156 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947156 HOGENOM HOG000124003 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000124003&db=HOGENOM6 IntAct P0AD53 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AD53* InterPro IPR018994 http://www.ebi.ac.uk/interpro/entry/IPR018994 KEGG_Gene ecj:JW2646 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2646 KEGG_Gene eco:b2671 http://www.genome.jp/dbget-bin/www_bget?eco:b2671 OMA PKTYGYR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PKTYGYR PSORT swissprot:YGAC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGAC_ECOLI PSORT-B swissprot:YGAC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGAC_ECOLI PSORT2 swissprot:YGAC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGAC_ECOLI Pfam PF09400 http://pfam.xfam.org/family/PF09400 Phobius swissprot:YGAC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGAC_ECOLI ProteinModelPortal P0AD53 http://www.proteinmodelportal.org/query/uniprot/P0AD53 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7961433 http://www.ncbi.nlm.nih.gov/pubmed/7961433 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417157 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417157 RefSeq WP_000281320 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000281320 SMR P0AD53 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AD53 STRING 511145.b2671 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2671&targetmode=cogs UniProtKB YGAC_ECOLI http://www.uniprot.org/uniprot/YGAC_ECOLI UniProtKB-AC P0AD53 http://www.uniprot.org/uniprot/P0AD53 charge swissprot:YGAC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGAC_ECOLI eggNOG ENOG4108WMJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108WMJ eggNOG ENOG4111KTT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111KTT epestfind swissprot:YGAC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGAC_ECOLI garnier swissprot:YGAC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGAC_ECOLI helixturnhelix swissprot:YGAC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGAC_ECOLI hmoment swissprot:YGAC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGAC_ECOLI iep swissprot:YGAC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGAC_ECOLI inforesidue swissprot:YGAC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGAC_ECOLI octanol swissprot:YGAC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGAC_ECOLI pepcoil swissprot:YGAC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGAC_ECOLI pepdigest swissprot:YGAC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGAC_ECOLI pepinfo swissprot:YGAC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGAC_ECOLI pepnet swissprot:YGAC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGAC_ECOLI pepstats swissprot:YGAC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGAC_ECOLI pepwheel swissprot:YGAC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGAC_ECOLI pepwindow swissprot:YGAC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGAC_ECOLI sigcleave swissprot:YGAC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGAC_ECOLI ## Database ID URL or Descriptions # BioGrid 4259661 3 # EcoGene EG12745 yqjF # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR032808 DoxX # Organism YQJF_ECOLI Escherichia coli (strain K12) # PATRIC 32121622 VBIEscCol129921_3197 # Pfam PF07681 DoxX # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQJF_ECOLI Inner membrane protein YqjF # RefSeq NP_417572 NC_000913.3 # RefSeq WP_000732240 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA57905.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the DoxX family. {ECO 0000305}. # SUBCELLULAR LOCATION YQJF_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG COG2259 LUCA # eggNOG ENOG4108VBZ Bacteria BLAST swissprot:YQJF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQJF_ECOLI BioCyc ECOL316407:JW5850-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5850-MONOMER BioCyc EcoCyc:G7615-MONOMER http://biocyc.org/getid?id=EcoCyc:G7615-MONOMER COG COG2259 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2259 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2601 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2601 EcoGene EG12745 http://www.ecogene.org/geneInfo.php?eg_id=EG12745 EnsemblBacteria AAC76136 http://www.ensemblgenomes.org/id/AAC76136 EnsemblBacteria AAC76136 http://www.ensemblgenomes.org/id/AAC76136 EnsemblBacteria BAE77151 http://www.ensemblgenomes.org/id/BAE77151 EnsemblBacteria BAE77151 http://www.ensemblgenomes.org/id/BAE77151 EnsemblBacteria BAE77151 http://www.ensemblgenomes.org/id/BAE77151 EnsemblBacteria b3101 http://www.ensemblgenomes.org/id/b3101 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 947608 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947608 HOGENOM HOG000198398 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000198398&db=HOGENOM6 InParanoid P42619 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P42619 InterPro IPR032808 http://www.ebi.ac.uk/interpro/entry/IPR032808 KEGG_Gene ecj:JW5850 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5850 KEGG_Gene eco:b3101 http://www.genome.jp/dbget-bin/www_bget?eco:b3101 KEGG_Orthology KO:K15977 http://www.genome.jp/dbget-bin/www_bget?KO:K15977 OMA RILLSFM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RILLSFM PSORT swissprot:YQJF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQJF_ECOLI PSORT-B swissprot:YQJF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQJF_ECOLI PSORT2 swissprot:YQJF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQJF_ECOLI Pfam PF07681 http://pfam.xfam.org/family/PF07681 Phobius swissprot:YQJF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQJF_ECOLI ProteinModelPortal P42619 http://www.proteinmodelportal.org/query/uniprot/P42619 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417572 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417572 RefSeq WP_000732240 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000732240 STRING 511145.b3101 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3101&targetmode=cogs STRING COG2259 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2259&targetmode=cogs UniProtKB YQJF_ECOLI http://www.uniprot.org/uniprot/YQJF_ECOLI UniProtKB-AC P42619 http://www.uniprot.org/uniprot/P42619 charge swissprot:YQJF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQJF_ECOLI eggNOG COG2259 http://eggnogapi.embl.de/nog_data/html/tree/COG2259 eggNOG ENOG4108VBZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108VBZ epestfind swissprot:YQJF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQJF_ECOLI garnier swissprot:YQJF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQJF_ECOLI helixturnhelix swissprot:YQJF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQJF_ECOLI hmoment swissprot:YQJF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQJF_ECOLI iep swissprot:YQJF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQJF_ECOLI inforesidue swissprot:YQJF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQJF_ECOLI octanol swissprot:YQJF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQJF_ECOLI pepcoil swissprot:YQJF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQJF_ECOLI pepdigest swissprot:YQJF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQJF_ECOLI pepinfo swissprot:YQJF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQJF_ECOLI pepnet swissprot:YQJF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQJF_ECOLI pepstats swissprot:YQJF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQJF_ECOLI pepwheel swissprot:YQJF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQJF_ECOLI pepwindow swissprot:YQJF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQJF_ECOLI sigcleave swissprot:YQJF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQJF_ECOLI ## Database ID URL or Descriptions # BioGrid 4262121 63 # CATALYTIC ACTIVITY DPO3E_ECOLI Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). # CDD cd06131 DNA_pol_III_epsilon_Ecoli_like # COFACTOR DPO3E_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Note=Binds 2 divalent metal cations. Magnesium or manganese.; # EcoGene EG10243 dnaQ # FUNCTION DPO3E_ECOLI DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease. # GO_component GO:0044776 DNA polymerase III, core complex; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_function GO:0003887 DNA-directed DNA polymerase activity; IEA:UniProtKB-KW. # GO_function GO:0004527 exonuclease activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0045004 DNA replication proofreading; IMP:EcoCyc. # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004518 nuclease activity # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # Gene3D 3.30.420.10 -; 1. # INTERACTION DPO3E_ECOLI P10443 dnaE; NbExp=20; IntAct=EBI-549131, EBI-549111; P0A988 dnaN; NbExp=6; IntAct=EBI-549131, EBI-542385; P06710 dnaX; NbExp=4; IntAct=EBI-549131, EBI-549140; P0ABS8 holE; NbExp=11; IntAct=EBI-549131, EBI-549182; # IntAct P03007 28 # InterPro IPR006054 DnaQ # InterPro IPR006309 DnaQ_proteo # InterPro IPR012337 RNaseH-like_dom # InterPro IPR013520 Exonuclease_RNaseT/DNA_pol3 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03032 DNA replication proteins # KEGG_Brite ko03032 M00260 DNA polymerase III complex, bacteria # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Brite ko03400 M00260 DNA polymerase III complex, bacteria # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00240 Pyrimidine metabolism # KEGG_Pathway ko03030 DNA replication # KEGG_Pathway ko03430 Mismatch repair # KEGG_Pathway ko03440 Homologous recombination # Organism DPO3E_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30231:SF0 PTHR30231:SF0 # PATRIC 32115543 VBIEscCol129921_0217 # PDB 1J53 X-ray; 1.80 A; A=1-186 # PDB 1J54 X-ray; 1.70 A; A=1-186 # PDB 1MGZ Model; -; A=1-186 # PDB 2GUI X-ray; 1.60 A; A=2-186 # PDB 2IDO X-ray; 2.10 A; A/C=1-186 # PDB 2XY8 NMR; -; A=1-186 # PDB 4GX8 X-ray; 1.70 A; A/B/C/D=209-243 # PDB 4GX9 X-ray; 2.15 A; A/B/C/D=200-243 # PDB 5FKU EM; 8.34 A; D=1-243 # PDB 5FKV EM; 8.00 A; D=1-243 # PDB 5FKW EM; 7.30 A; D=1-243 # PIR A64746 IQECQ # Pfam PF00929 RNase_T # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DPO3E_ECOLI DNA polymerase III subunit epsilon # RefSeq NP_414751 NC_000913.3 # SEQUENCE CAUTION Sequence=AAB08637.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SMART SM00479 EXOIII # SUBUNIT DPO3E_ECOLI The DNA polymerase holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential subassemblies the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core (subunits alpha,epsilon and theta) contains the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork. This complex contains delta, delta', psi and chi, and copies of either or both of two different DnaX proteins, gamma and tau. The composition of the holoenzyme is, therefore (alpha,epsilon,theta)[2]-(gamma/tau)[3]-delta,delta', psi,chi- beta[4]. {ECO 0000269|PubMed 11937058}. # SUPFAM SSF53098 SSF53098 # TIGRFAMs TIGR00573 dnaq # TIGRFAMs TIGR01406 dnaQ_proteo # eggNOG COG0847 LUCA # eggNOG ENOG4107RZZ Bacteria BLAST swissprot:DPO3E_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DPO3E_ECOLI BioCyc ECOL316407:JW0205-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0205-MONOMER BioCyc EcoCyc:EG10243-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10243-MONOMER BioCyc MetaCyc:EG10243-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10243-MONOMER COG COG0847 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0847 DIP DIP-9462N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9462N DOI 10.1002/bies.950140206 http://dx.doi.org/10.1002/bies.950140206 DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1007/BF02428026 http://dx.doi.org/10.1007/BF02428026 DOI 10.1016/0022-2836(86)90080-X http://dx.doi.org/10.1016/0022-2836(86)90080-X DOI 10.1016/S0969-2126(02)00738-4 http://dx.doi.org/10.1016/S0969-2126(02)00738-4 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.80.23.7137 http://dx.doi.org/10.1073/pnas.80.23.7137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.7.7 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.7 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K00985 http://www.ebi.ac.uk/ena/data/view/K00985 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EMBL X04027 http://www.ebi.ac.uk/ena/data/view/X04027 ENZYME 2.7.7.7 http://enzyme.expasy.org/EC/2.7.7.7 EchoBASE EB0239 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0239 EcoGene EG10243 http://www.ecogene.org/geneInfo.php?eg_id=EG10243 EnsemblBacteria AAC73320 http://www.ensemblgenomes.org/id/AAC73320 EnsemblBacteria AAC73320 http://www.ensemblgenomes.org/id/AAC73320 EnsemblBacteria BAA77886 http://www.ensemblgenomes.org/id/BAA77886 EnsemblBacteria BAA77886 http://www.ensemblgenomes.org/id/BAA77886 EnsemblBacteria BAA77886 http://www.ensemblgenomes.org/id/BAA77886 EnsemblBacteria b0215 http://www.ensemblgenomes.org/id/b0215 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0044776 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044776 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003887 GO_function GO:0004527 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004527 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0045004 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045004 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.30.420.10 http://www.cathdb.info/version/latest/superfamily/3.30.420.10 GeneID 946441 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946441 HOGENOM HOG000258616 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000258616&db=HOGENOM6 InParanoid P03007 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P03007 IntAct P03007 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P03007* IntEnz 2.7.7.7 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.7 InterPro IPR006054 http://www.ebi.ac.uk/interpro/entry/IPR006054 InterPro IPR006309 http://www.ebi.ac.uk/interpro/entry/IPR006309 InterPro IPR012337 http://www.ebi.ac.uk/interpro/entry/IPR012337 InterPro IPR013520 http://www.ebi.ac.uk/interpro/entry/IPR013520 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03032 http://www.genome.jp/dbget-bin/www_bget?ko03032 KEGG_Brite ko03032 http://www.genome.jp/dbget-bin/www_bget?ko03032 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW0205 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0205 KEGG_Gene eco:b0215 http://www.genome.jp/dbget-bin/www_bget?eco:b0215 KEGG_Orthology KO:K02342 http://www.genome.jp/dbget-bin/www_bget?KO:K02342 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Pathway ko03030 http://www.genome.jp/kegg-bin/show_pathway?ko03030 KEGG_Pathway ko03430 http://www.genome.jp/kegg-bin/show_pathway?ko03430 KEGG_Pathway ko03440 http://www.genome.jp/kegg-bin/show_pathway?ko03440 KEGG_Reaction rn:R00375 http://www.genome.jp/dbget-bin/www_bget?rn:R00375 KEGG_Reaction rn:R00376 http://www.genome.jp/dbget-bin/www_bget?rn:R00376 KEGG_Reaction rn:R00377 http://www.genome.jp/dbget-bin/www_bget?rn:R00377 KEGG_Reaction rn:R00378 http://www.genome.jp/dbget-bin/www_bget?rn:R00378 MINT MINT-1222832 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1222832 OMA FHVYLNP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FHVYLNP PANTHER PTHR30231:SF0 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30231:SF0 PDB 1J53 http://www.ebi.ac.uk/pdbe-srv/view/entry/1J53 PDB 1J54 http://www.ebi.ac.uk/pdbe-srv/view/entry/1J54 PDB 1MGZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1MGZ PDB 2GUI http://www.ebi.ac.uk/pdbe-srv/view/entry/2GUI PDB 2IDO http://www.ebi.ac.uk/pdbe-srv/view/entry/2IDO PDB 2XY8 http://www.ebi.ac.uk/pdbe-srv/view/entry/2XY8 PDB 4GX8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4GX8 PDB 4GX9 http://www.ebi.ac.uk/pdbe-srv/view/entry/4GX9 PDB 5FKU http://www.ebi.ac.uk/pdbe-srv/view/entry/5FKU PDB 5FKV http://www.ebi.ac.uk/pdbe-srv/view/entry/5FKV PDB 5FKW http://www.ebi.ac.uk/pdbe-srv/view/entry/5FKW PDBsum 1J53 http://www.ebi.ac.uk/pdbsum/1J53 PDBsum 1J54 http://www.ebi.ac.uk/pdbsum/1J54 PDBsum 1MGZ http://www.ebi.ac.uk/pdbsum/1MGZ PDBsum 2GUI http://www.ebi.ac.uk/pdbsum/2GUI PDBsum 2IDO http://www.ebi.ac.uk/pdbsum/2IDO PDBsum 2XY8 http://www.ebi.ac.uk/pdbsum/2XY8 PDBsum 4GX8 http://www.ebi.ac.uk/pdbsum/4GX8 PDBsum 4GX9 http://www.ebi.ac.uk/pdbsum/4GX9 PDBsum 5FKU http://www.ebi.ac.uk/pdbsum/5FKU PDBsum 5FKV http://www.ebi.ac.uk/pdbsum/5FKV PDBsum 5FKW http://www.ebi.ac.uk/pdbsum/5FKW PSORT swissprot:DPO3E_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DPO3E_ECOLI PSORT-B swissprot:DPO3E_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DPO3E_ECOLI PSORT2 swissprot:DPO3E_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DPO3E_ECOLI Pfam PF00929 http://pfam.xfam.org/family/PF00929 Phobius swissprot:DPO3E_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DPO3E_ECOLI PhylomeDB P03007 http://phylomedb.org/?seqid=P03007 ProteinModelPortal P03007 http://www.proteinmodelportal.org/query/uniprot/P03007 PubMed 11937058 http://www.ncbi.nlm.nih.gov/pubmed/11937058 PubMed 1575709 http://www.ncbi.nlm.nih.gov/pubmed/1575709 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3023634 http://www.ncbi.nlm.nih.gov/pubmed/3023634 PubMed 3540531 http://www.ncbi.nlm.nih.gov/pubmed/3540531 PubMed 6316347 http://www.ncbi.nlm.nih.gov/pubmed/6316347 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_414751 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414751 SMART SM00479 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00479 SMR P03007 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P03007 STRING 511145.b0215 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0215&targetmode=cogs STRING COG0847 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0847&targetmode=cogs SUPFAM SSF53098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098 SWISS-2DPAGE P03007 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P03007 TIGRFAMs TIGR00573 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00573 TIGRFAMs TIGR01406 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01406 UniProtKB DPO3E_ECOLI http://www.uniprot.org/uniprot/DPO3E_ECOLI UniProtKB-AC P03007 http://www.uniprot.org/uniprot/P03007 charge swissprot:DPO3E_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DPO3E_ECOLI eggNOG COG0847 http://eggnogapi.embl.de/nog_data/html/tree/COG0847 eggNOG ENOG4107RZZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107RZZ epestfind swissprot:DPO3E_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DPO3E_ECOLI garnier swissprot:DPO3E_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DPO3E_ECOLI helixturnhelix swissprot:DPO3E_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DPO3E_ECOLI hmoment swissprot:DPO3E_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DPO3E_ECOLI iep swissprot:DPO3E_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DPO3E_ECOLI inforesidue swissprot:DPO3E_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DPO3E_ECOLI octanol swissprot:DPO3E_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DPO3E_ECOLI pepcoil swissprot:DPO3E_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DPO3E_ECOLI pepdigest swissprot:DPO3E_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DPO3E_ECOLI pepinfo swissprot:DPO3E_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DPO3E_ECOLI pepnet swissprot:DPO3E_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DPO3E_ECOLI pepstats swissprot:DPO3E_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DPO3E_ECOLI pepwheel swissprot:DPO3E_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DPO3E_ECOLI pepwindow swissprot:DPO3E_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DPO3E_ECOLI sigcleave swissprot:DPO3E_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DPO3E_ECOLI ## Database ID URL or Descriptions # BioGrid 4259448 8 # EcoGene EG11913 yijO # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0000987 core promoter proximal region sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IBA:GO_Central. # GO_process GO:0006351 transcription, DNA-templated; ISS:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.60 -; 2. # Gene3D 2.60.120.10 -; 1. # IntAct P32677 4 # InterPro IPR009057 Homeodomain-like # InterPro IPR014710 RmlC-like_jellyroll # InterPro IPR018060 HTH_AraC # InterPro IPR018062 HTH_AraC-typ_CS # InterPro IPR020449 Tscrpt_reg_HTH_AraC-type # Organism YIJO_ECOLI Escherichia coli (strain K12) # PATRIC 32123429 VBIEscCol129921_4075 # PIR E65202 E65202 # PRINTS PR00032 HTHARAC # PROSITE PS00041 HTH_ARAC_FAMILY_1 # PROSITE PS01124 HTH_ARAC_FAMILY_2 # Pfam PF12833 HTH_18 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIJO_ECOLI Uncharacterized HTH-type transcriptional regulator YijO # RefSeq NP_418389 NC_000913.3 # RefSeq WP_000274636 NZ_LN832404.1 # SIMILARITY Contains 1 HTH araC/xylS-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00593}. # SMART SM00342 HTH_ARAC # SUPFAM SSF46689 SSF46689 # eggNOG ENOG4106R3P Bacteria # eggNOG ENOG410YHRH LUCA BLAST swissprot:YIJO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIJO_ECOLI BioCyc ECOL316407:JW3926-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3926-MONOMER BioCyc EcoCyc:EG11913-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11913-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1857 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1857 EcoGene EG11913 http://www.ecogene.org/geneInfo.php?eg_id=EG11913 EnsemblBacteria AAC76936 http://www.ensemblgenomes.org/id/AAC76936 EnsemblBacteria AAC76936 http://www.ensemblgenomes.org/id/AAC76936 EnsemblBacteria BAE77357 http://www.ensemblgenomes.org/id/BAE77357 EnsemblBacteria BAE77357 http://www.ensemblgenomes.org/id/BAE77357 EnsemblBacteria BAE77357 http://www.ensemblgenomes.org/id/BAE77357 EnsemblBacteria b3954 http://www.ensemblgenomes.org/id/b3954 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000987 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000987 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 Gene3D 2.60.120.10 http://www.cathdb.info/version/latest/superfamily/2.60.120.10 GeneID 948451 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948451 HOGENOM HOG000274763 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000274763&db=HOGENOM6 InParanoid P32677 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32677 IntAct P32677 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32677* InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR014710 http://www.ebi.ac.uk/interpro/entry/IPR014710 InterPro IPR018060 http://www.ebi.ac.uk/interpro/entry/IPR018060 InterPro IPR018062 http://www.ebi.ac.uk/interpro/entry/IPR018062 InterPro IPR020449 http://www.ebi.ac.uk/interpro/entry/IPR020449 KEGG_Gene ecj:JW3926 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3926 KEGG_Gene eco:b3954 http://www.genome.jp/dbget-bin/www_bget?eco:b3954 OMA AVGFNEY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AVGFNEY PRINTS PR00032 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00032 PROSITE PS00041 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00041 PROSITE PS01124 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01124 PSORT swissprot:YIJO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIJO_ECOLI PSORT-B swissprot:YIJO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIJO_ECOLI PSORT2 swissprot:YIJO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIJO_ECOLI Pfam PF12833 http://pfam.xfam.org/family/PF12833 Phobius swissprot:YIJO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIJO_ECOLI PhylomeDB P32677 http://phylomedb.org/?seqid=P32677 ProteinModelPortal P32677 http://www.proteinmodelportal.org/query/uniprot/P32677 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418389 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418389 RefSeq WP_000274636 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000274636 SMART SM00342 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00342 SMR P32677 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32677 STRING 511145.b3954 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3954&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 UniProtKB YIJO_ECOLI http://www.uniprot.org/uniprot/YIJO_ECOLI UniProtKB-AC P32677 http://www.uniprot.org/uniprot/P32677 charge swissprot:YIJO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIJO_ECOLI eggNOG ENOG4106R3P http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106R3P eggNOG ENOG410YHRH http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YHRH epestfind swissprot:YIJO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIJO_ECOLI garnier swissprot:YIJO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIJO_ECOLI helixturnhelix swissprot:YIJO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIJO_ECOLI hmoment swissprot:YIJO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIJO_ECOLI iep swissprot:YIJO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIJO_ECOLI inforesidue swissprot:YIJO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIJO_ECOLI octanol swissprot:YIJO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIJO_ECOLI pepcoil swissprot:YIJO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIJO_ECOLI pepdigest swissprot:YIJO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIJO_ECOLI pepinfo swissprot:YIJO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIJO_ECOLI pepnet swissprot:YIJO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIJO_ECOLI pepstats swissprot:YIJO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIJO_ECOLI pepwheel swissprot:YIJO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIJO_ECOLI pepwindow swissprot:YIJO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIJO_ECOLI sigcleave swissprot:YIJO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIJO_ECOLI ## Database ID URL or Descriptions # BioGrid 4262748 186 # EcoGene EG10311 fimD # FUNCTION FIMD_ECOLI Involved in the export and assembly of FimA fimbrial subunits across the outer membrane. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015473 fimbrial usher porin activity; IDA:EcoCyc. # GO_process GO:0009297 pilus assembly; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0022607 cellular component assembly # IntAct P30130 7 # InterPro IPR000015 Fimb_usher # InterPro IPR018030 Fimbrial_membr_usher_CS # InterPro IPR025885 PapC_N # InterPro IPR025949 PapC-like_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02000 Transporters # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko05133 Pertussis # Organism FIMD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30451 PTHR30451 # PATRIC 32124230 VBIEscCol129921_4458 # PDB 1ZDV NMR; -; A=70-184 # PDB 1ZDX NMR; -; A=70-170 # PDB 1ZE3 X-ray; 1.84 A; D=46-170 # PDB 3BWU X-ray; 1.76 A; D=46-170 # PDB 3OHN X-ray; 3.01 A; A/B=169-708 # PDB 3RFZ X-ray; 2.80 A; B/E=46-878 # PDB 4J3O X-ray; 3.80 A; D=46-878 # PIR S56542 S56542 # PROSITE PS01151 FIMBRIAL_USHER # Pfam PF00577 Usher # Pfam PF13953 PapC_C # Pfam PF13954 PapC_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FIMD_ECOLI Outer membrane usher protein FimD # RefSeq NP_418737 NC_000913.3 # RefSeq WP_000121005 NZ_LN832404.1 # SIMILARITY Belongs to the fimbrial export usher family. {ECO 0000305}. # SUBCELLULAR LOCATION FIMD_ECOLI Cell outer membrane {ECO 0000250}; Multi- pass membrane protein {ECO 0000250}. # TCDB 1.B.11.3 the outer membrane fimbrial usher porin (fup) family # eggNOG COG3188 LUCA # eggNOG ENOG4105CW0 Bacteria BLAST swissprot:FIMD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FIMD_ECOLI BioCyc ECOL316407:JW5780-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5780-MONOMER BioCyc EcoCyc:EG10311-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10311-MONOMER COG COG3188 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3188 DIP DIP-9612N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9612N DOI 10.1007/BF00260505 http://dx.doi.org/10.1007/BF00260505 DOI 10.1016/S0022-2836(03)00591-6 http://dx.doi.org/10.1016/S0022-2836(03)00591-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X51655 http://www.ebi.ac.uk/ena/data/view/X51655 EchoBASE EB0307 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0307 EcoGene EG10311 http://www.ecogene.org/geneInfo.php?eg_id=EG10311 EnsemblBacteria AAC77273 http://www.ensemblgenomes.org/id/AAC77273 EnsemblBacteria AAC77273 http://www.ensemblgenomes.org/id/AAC77273 EnsemblBacteria BAE78310 http://www.ensemblgenomes.org/id/BAE78310 EnsemblBacteria BAE78310 http://www.ensemblgenomes.org/id/BAE78310 EnsemblBacteria BAE78310 http://www.ensemblgenomes.org/id/BAE78310 EnsemblBacteria b4317 http://www.ensemblgenomes.org/id/b4317 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015473 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015473 GO_process GO:0009297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009297 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GeneID 948844 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948844 HOGENOM HOG000111414 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000111414&db=HOGENOM6 InParanoid P30130 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30130 IntAct P30130 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P30130* InterPro IPR000015 http://www.ebi.ac.uk/interpro/entry/IPR000015 InterPro IPR018030 http://www.ebi.ac.uk/interpro/entry/IPR018030 InterPro IPR025885 http://www.ebi.ac.uk/interpro/entry/IPR025885 InterPro IPR025949 http://www.ebi.ac.uk/interpro/entry/IPR025949 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW5780 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5780 KEGG_Gene eco:b4317 http://www.genome.jp/dbget-bin/www_bget?eco:b4317 KEGG_Orthology KO:K07347 http://www.genome.jp/dbget-bin/www_bget?KO:K07347 KEGG_Pathway ko05133 http://www.genome.jp/kegg-bin/show_pathway?ko05133 MINT MINT-1292016 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1292016 OMA VPQAFMG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VPQAFMG PANTHER PTHR30451 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30451 PDB 1ZDV http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZDV PDB 1ZDX http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZDX PDB 1ZE3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZE3 PDB 3BWU http://www.ebi.ac.uk/pdbe-srv/view/entry/3BWU PDB 3OHN http://www.ebi.ac.uk/pdbe-srv/view/entry/3OHN PDB 3RFZ http://www.ebi.ac.uk/pdbe-srv/view/entry/3RFZ PDB 4J3O http://www.ebi.ac.uk/pdbe-srv/view/entry/4J3O PDBsum 1ZDV http://www.ebi.ac.uk/pdbsum/1ZDV PDBsum 1ZDX http://www.ebi.ac.uk/pdbsum/1ZDX PDBsum 1ZE3 http://www.ebi.ac.uk/pdbsum/1ZE3 PDBsum 3BWU http://www.ebi.ac.uk/pdbsum/3BWU PDBsum 3OHN http://www.ebi.ac.uk/pdbsum/3OHN PDBsum 3RFZ http://www.ebi.ac.uk/pdbsum/3RFZ PDBsum 4J3O http://www.ebi.ac.uk/pdbsum/4J3O PROSITE PS01151 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01151 PSORT swissprot:FIMD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FIMD_ECOLI PSORT-B swissprot:FIMD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FIMD_ECOLI PSORT2 swissprot:FIMD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FIMD_ECOLI Pfam PF00577 http://pfam.xfam.org/family/PF00577 Pfam PF13953 http://pfam.xfam.org/family/PF13953 Pfam PF13954 http://pfam.xfam.org/family/PF13954 Phobius swissprot:FIMD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FIMD_ECOLI PhylomeDB P30130 http://phylomedb.org/?seqid=P30130 ProteinModelPortal P30130 http://www.proteinmodelportal.org/query/uniprot/P30130 PubMed 12842468 http://www.ncbi.nlm.nih.gov/pubmed/12842468 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1970114 http://www.ncbi.nlm.nih.gov/pubmed/1970114 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418737 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418737 RefSeq WP_000121005 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000121005 SMR P30130 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P30130 STRING 511145.b4317 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4317&targetmode=cogs STRING COG3188 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3188&targetmode=cogs TCDB 1.B.11.3 http://www.tcdb.org/search/result.php?tc=1.B.11.3 UniProtKB FIMD_ECOLI http://www.uniprot.org/uniprot/FIMD_ECOLI UniProtKB-AC P30130 http://www.uniprot.org/uniprot/P30130 charge swissprot:FIMD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FIMD_ECOLI eggNOG COG3188 http://eggnogapi.embl.de/nog_data/html/tree/COG3188 eggNOG ENOG4105CW0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CW0 epestfind swissprot:FIMD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FIMD_ECOLI garnier swissprot:FIMD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FIMD_ECOLI helixturnhelix swissprot:FIMD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FIMD_ECOLI hmoment swissprot:FIMD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FIMD_ECOLI iep swissprot:FIMD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FIMD_ECOLI inforesidue swissprot:FIMD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FIMD_ECOLI octanol swissprot:FIMD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FIMD_ECOLI pepcoil swissprot:FIMD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FIMD_ECOLI pepdigest swissprot:FIMD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FIMD_ECOLI pepinfo swissprot:FIMD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FIMD_ECOLI pepnet swissprot:FIMD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FIMD_ECOLI pepstats swissprot:FIMD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FIMD_ECOLI pepwheel swissprot:FIMD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FIMD_ECOLI pepwindow swissprot:FIMD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FIMD_ECOLI sigcleave swissprot:FIMD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FIMD_ECOLI ## Database ID URL or Descriptions # BioGrid 4259358 11 # EcoGene EG12621 csgB # FUNCTION CSGB_ECOLI Curlin is the structural subunit of the curli fimbriae. Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_component GO:0009289 pilus; IDA:EcoCyc. # GO_process GO:0007155 cell adhesion; IMP:EcoCyc. # GO_process GO:0044010 single-species biofilm formation; IMP:EcoCyc. # GO_process GO:1990000 amyloid fibril formation; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0007155 cell adhesion # GOslim_process GO:0008150 biological_process # GOslim_process GO:0030198 extracellular matrix organization # INDUCTION Under control of the CsgD transcription factor, part of the csgBAC/ymdA operon. {ECO:0000269|PubMed 17010156}. # InterPro IPR009742 Curlin_rpt # KEGG_Brite ko02044 Secretion system # Organism CSGB_ECOLI Escherichia coli (strain K12) # PATRIC 32117319 VBIEscCol129921_1082 # PIR S70787 S70787 # Pfam PF07012 Curlin_rpt; 3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CSGB_ECOLI Minor curlin subunit # RefSeq NP_415559 NC_000913.3 # RefSeq WP_000791650 NZ_LN832404.1 # SIMILARITY Belongs to the CsgA/CsgB family. {ECO 0000305}. # SUBCELLULAR LOCATION CSGB_ECOLI Fimbrium. Note=Part of the curli surface structure. # eggNOG ENOG4108U0V Bacteria # eggNOG ENOG4111G8B LUCA BLAST swissprot:CSGB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CSGB_ECOLI BioCyc ECOL316407:JW1024-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1024-MONOMER BioCyc EcoCyc:G6547-MONOMER http://biocyc.org/getid?id=EcoCyc:G6547-MONOMER DIP DIP-46504N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-46504N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1994.tb00493.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb00493.x DOI 10.1111/j.1365-2958.1995.mmi_18040661.x http://dx.doi.org/10.1111/j.1365-2958.1995.mmi_18040661.x DOI 10.1111/j.1365-2958.2006.05440.x http://dx.doi.org/10.1111/j.1365-2958.2006.05440.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X90754 http://www.ebi.ac.uk/ena/data/view/X90754 EchoBASE EB2505 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2505 EcoGene EG12621 http://www.ecogene.org/geneInfo.php?eg_id=EG12621 EnsemblBacteria AAC74125 http://www.ensemblgenomes.org/id/AAC74125 EnsemblBacteria AAC74125 http://www.ensemblgenomes.org/id/AAC74125 EnsemblBacteria BAA35831 http://www.ensemblgenomes.org/id/BAA35831 EnsemblBacteria BAA35831 http://www.ensemblgenomes.org/id/BAA35831 EnsemblBacteria BAA35831 http://www.ensemblgenomes.org/id/BAA35831 EnsemblBacteria b1041 http://www.ensemblgenomes.org/id/b1041 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0009289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009289 GO_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GO_process GO:0044010 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044010 GO_process GO:1990000 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990000 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0030198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030198 GeneID 947391 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947391 HOGENOM HOG000118940 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118940&db=HOGENOM6 InParanoid P0ABK7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABK7 InterPro IPR009742 http://www.ebi.ac.uk/interpro/entry/IPR009742 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW1024 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1024 KEGG_Gene eco:b1041 http://www.genome.jp/dbget-bin/www_bget?eco:b1041 KEGG_Orthology KO:K04335 http://www.genome.jp/dbget-bin/www_bget?KO:K04335 OMA INIVQGR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=INIVQGR PSORT swissprot:CSGB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CSGB_ECOLI PSORT-B swissprot:CSGB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CSGB_ECOLI PSORT2 swissprot:CSGB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CSGB_ECOLI Pfam PF07012 http://pfam.xfam.org/family/PF07012 Phobius swissprot:CSGB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CSGB_ECOLI PhylomeDB P0ABK7 http://phylomedb.org/?seqid=P0ABK7 ProteinModelPortal P0ABK7 http://www.proteinmodelportal.org/query/uniprot/P0ABK7 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17010156 http://www.ncbi.nlm.nih.gov/pubmed/17010156 PubMed 7854117 http://www.ncbi.nlm.nih.gov/pubmed/7854117 PubMed 8817489 http://www.ncbi.nlm.nih.gov/pubmed/8817489 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415559 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415559 RefSeq WP_000791650 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000791650 STRING 511145.b1041 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1041&targetmode=cogs UniProtKB CSGB_ECOLI http://www.uniprot.org/uniprot/CSGB_ECOLI UniProtKB-AC P0ABK7 http://www.uniprot.org/uniprot/P0ABK7 charge swissprot:CSGB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CSGB_ECOLI eggNOG ENOG4108U0V http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108U0V eggNOG ENOG4111G8B http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111G8B epestfind swissprot:CSGB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CSGB_ECOLI garnier swissprot:CSGB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CSGB_ECOLI helixturnhelix swissprot:CSGB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CSGB_ECOLI hmoment swissprot:CSGB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CSGB_ECOLI iep swissprot:CSGB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CSGB_ECOLI inforesidue swissprot:CSGB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CSGB_ECOLI octanol swissprot:CSGB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CSGB_ECOLI pepcoil swissprot:CSGB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CSGB_ECOLI pepdigest swissprot:CSGB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CSGB_ECOLI pepinfo swissprot:CSGB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CSGB_ECOLI pepnet swissprot:CSGB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CSGB_ECOLI pepstats swissprot:CSGB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CSGB_ECOLI pepwheel swissprot:CSGB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CSGB_ECOLI pepwindow swissprot:CSGB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CSGB_ECOLI sigcleave swissprot:CSGB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CSGB_ECOLI ## Database ID URL or Descriptions # AltName PHYDA_ECOLI Hydantoin-utilizing enzyme HyuA # BIOPHYSICOCHEMICAL PROPERTIES PHYDA_ECOLI Kinetic parameters KM=7.8 mM for phenylhydantoin {ECO 0000269|PubMed 11092864}; KM=32.8 mM for hydroxyphenylhydantoin {ECO 0000269|PubMed 11092864}; KM=138 mM for hydantoin {ECO 0000269|PubMed 11092864}; Vmax=12.6 umol/min/mg enzyme with hydroxyphenylhydantoin as substrate {ECO 0000269|PubMed 11092864}; Vmax=3.3 umol/min/mg enzyme with phenylhydantoin as substrate {ECO 0000269|PubMed 11092864}; Vmax=0.15 umol/min/mg enzyme with hydantoin as substrate {ECO 0000269|PubMed 11092864}; Note=Hydantoin derivatives with an aliphatic or no side chain at their 5'-position results in a much lower level of activity than those with aromatic side chains at the 5'-position.; pH dependence Optimum pH is 8-8.5. {ECO 0000269|PubMed 11092864}; Temperature dependence Optimum temperature is 45-50 degrees Celsius. {ECO 0000269|PubMed 11092864}; # BioGrid 4261249 7 # CDD cd01314 D-HYD # COFACTOR PHYDA_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 11092864, ECO 0000305}; Name=Ni(2+); Xref=ChEBI CHEBI 49786; Evidence={ECO 0000269|PubMed 11092864, ECO 0000305}; Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000269|PubMed 11092864, ECO 0000305}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 11092864, ECO 0000305}; Note=Binds 2 divalent metal cations per subunit. Can use zinc, nickel, cobalt or manganese. {ECO 0000269|PubMed 11092864, ECO 0000305}; # EcoGene EG13056 hyuA # FUNCTION PHYDA_ECOLI Catalyzes the stereospecific hydrolysis of the cyclic amide bond of D-hydantoin derivatives with an aromatic side chains at the 5'-position. Has no activity on dihydropyrimidines. The physiological function is unknown. {ECO 0000269|PubMed 11092864}. # GO_component GO:0005737 cytoplasm; IEA:InterPro. # GO_function GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides; IDA:EcoliWiki. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006208 pyrimidine nucleobase catabolic process; IEA:InterPro. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 2.30.40.10 -; 2. # HAMAP MF_01644 D_hydantoinase # IntAct Q46806 2 # InterPro IPR006680 Amidohydro-rel # InterPro IPR011059 Metal-dep_hydrolase_composite # InterPro IPR011778 Hydantoinase/dihydroPyrase # InterPro IPR023766 D_phenylhydantoinase # InterPro IPR032466 Metal_Hydrolase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00240 Pyrimidine metabolism # KEGG_Pathway ko00410 beta-Alanine metabolism # KEGG_Pathway ko00770 Pantothenate and CoA biosynthesis # KEGG_Pathway ko00983 Drug metabolism - other enzymes # Organism PHYDA_ECOLI Escherichia coli (strain K12) # PATRIC 32121156 VBIEscCol129921_2966 # PIR A65071 A65071 # PTM PHYDA_ECOLI Carbamylation allows a single lysine to coordinate two divalent metal cations. {ECO 0000250}. # Pfam PF01979 Amidohydro_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PHYDA_ECOLI D-phenylhydantoinase # RefSeq NP_417349 NC_000913.3 # RefSeq WP_001264442 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA83054.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily. {ECO 0000305}. # SUBUNIT Homotetramer. {ECO:0000269|PubMed 11092864}. # SUPFAM SSF51338 SSF51338; 2 # SUPFAM SSF51556 SSF51556 # TIGRFAMs TIGR02033 D-hydantoinase # eggNOG COG0044 LUCA # eggNOG ENOG4105CD3 Bacteria BLAST swissprot:PHYDA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PHYDA_ECOLI BioCyc ECOL316407:JW2841-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2841-MONOMER BioCyc EcoCyc:G7492-MONOMER http://biocyc.org/getid?id=EcoCyc:G7492-MONOMER BioCyc MetaCyc:G7492-MONOMER http://biocyc.org/getid?id=MetaCyc:G7492-MONOMER COG COG0044 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0044 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.24.7021-7028.2000 http://dx.doi.org/10.1128/JB.182.24.7021-7028.2000 EC_number EC:3.5.2.- http://www.genome.jp/dbget-bin/www_bget?EC:3.5.2.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 ENZYME 3.5.2.- http://enzyme.expasy.org/EC/3.5.2.- EchoBASE EB2868 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2868 EcoGene EG13056 http://www.ecogene.org/geneInfo.php?eg_id=EG13056 EnsemblBacteria AAC75911 http://www.ensemblgenomes.org/id/AAC75911 EnsemblBacteria AAC75911 http://www.ensemblgenomes.org/id/AAC75911 EnsemblBacteria BAE76939 http://www.ensemblgenomes.org/id/BAE76939 EnsemblBacteria BAE76939 http://www.ensemblgenomes.org/id/BAE76939 EnsemblBacteria BAE76939 http://www.ensemblgenomes.org/id/BAE76939 EnsemblBacteria b2873 http://www.ensemblgenomes.org/id/b2873 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0016812 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016812 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006208 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006208 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 2.30.40.10 http://www.cathdb.info/version/latest/superfamily/2.30.40.10 GeneID 947359 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947359 HAMAP MF_01644 http://hamap.expasy.org/unirule/MF_01644 HOGENOM HOG000219145 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219145&db=HOGENOM6 InParanoid Q46806 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46806 IntAct Q46806 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46806* IntEnz 3.5.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.2 InterPro IPR006680 http://www.ebi.ac.uk/interpro/entry/IPR006680 InterPro IPR011059 http://www.ebi.ac.uk/interpro/entry/IPR011059 InterPro IPR011778 http://www.ebi.ac.uk/interpro/entry/IPR011778 InterPro IPR023766 http://www.ebi.ac.uk/interpro/entry/IPR023766 InterPro IPR032466 http://www.ebi.ac.uk/interpro/entry/IPR032466 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2841 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2841 KEGG_Gene eco:b2873 http://www.genome.jp/dbget-bin/www_bget?eco:b2873 KEGG_Orthology KO:K01464 http://www.genome.jp/dbget-bin/www_bget?KO:K01464 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Pathway ko00410 http://www.genome.jp/kegg-bin/show_pathway?ko00410 KEGG_Pathway ko00770 http://www.genome.jp/kegg-bin/show_pathway?ko00770 KEGG_Pathway ko00983 http://www.genome.jp/kegg-bin/show_pathway?ko00983 KEGG_Reaction rn:R02269 http://www.genome.jp/dbget-bin/www_bget?rn:R02269 KEGG_Reaction rn:R03055 http://www.genome.jp/dbget-bin/www_bget?rn:R03055 KEGG_Reaction rn:R08227 http://www.genome.jp/dbget-bin/www_bget?rn:R08227 OMA GFHLMIS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GFHLMIS PSORT swissprot:PHYDA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PHYDA_ECOLI PSORT-B swissprot:PHYDA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PHYDA_ECOLI PSORT2 swissprot:PHYDA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PHYDA_ECOLI Pfam PF01979 http://pfam.xfam.org/family/PF01979 Phobius swissprot:PHYDA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PHYDA_ECOLI PhylomeDB Q46806 http://phylomedb.org/?seqid=Q46806 ProteinModelPortal Q46806 http://www.proteinmodelportal.org/query/uniprot/Q46806 PubMed 11092864 http://www.ncbi.nlm.nih.gov/pubmed/11092864 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417349 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417349 RefSeq WP_001264442 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001264442 SMR Q46806 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46806 STRING 511145.b2873 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2873&targetmode=cogs STRING COG0044 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0044&targetmode=cogs SUPFAM SSF51338 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51338 SUPFAM SSF51556 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51556 TIGRFAMs TIGR02033 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02033 UniProtKB PHYDA_ECOLI http://www.uniprot.org/uniprot/PHYDA_ECOLI UniProtKB-AC Q46806 http://www.uniprot.org/uniprot/Q46806 charge swissprot:PHYDA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PHYDA_ECOLI eggNOG COG0044 http://eggnogapi.embl.de/nog_data/html/tree/COG0044 eggNOG ENOG4105CD3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CD3 epestfind swissprot:PHYDA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PHYDA_ECOLI garnier swissprot:PHYDA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PHYDA_ECOLI helixturnhelix swissprot:PHYDA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PHYDA_ECOLI hmoment swissprot:PHYDA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PHYDA_ECOLI iep swissprot:PHYDA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PHYDA_ECOLI inforesidue swissprot:PHYDA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PHYDA_ECOLI octanol swissprot:PHYDA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PHYDA_ECOLI pepcoil swissprot:PHYDA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PHYDA_ECOLI pepdigest swissprot:PHYDA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PHYDA_ECOLI pepinfo swissprot:PHYDA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PHYDA_ECOLI pepnet swissprot:PHYDA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PHYDA_ECOLI pepstats swissprot:PHYDA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PHYDA_ECOLI pepwheel swissprot:PHYDA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PHYDA_ECOLI pepwindow swissprot:PHYDA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PHYDA_ECOLI sigcleave swissprot:PHYDA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PHYDA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262644 12 # CATALYTIC ACTIVITY ATP + protein L-histidine = ADP + protein N- phospho-L-histidine. {ECO:0000269|PubMed 9401031}. # CDD cd06225 HAMP # COFACTOR CPXA_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 9401031}; Note=Phosphotransfer to CpxR is stimulated by Mg(2+) and/or Mn(2+). {ECO 0000269|PubMed 9401031}; # DISRUPTION PHENOTYPE CPXA_ECOLI Loss of the Cpx envelope stress response (PubMed 10972835). Decreased resistance to the antibiotic amnikacin (PubMed 2185221). Single cpxA and double cpxR-cpxA mutant decrease transcription of degP (PubMed 7883164). Decreased transcription of cpxP (PubMed 9473036). Hypersensitive to alkaline pH (greater than pH 8.8) (PubMed 9473036). Decreased numbers of stationary phase cells bind to hydrophobic surfaces (PubMed 11830644). Greatly increased resistance to hydroxyurea, probably due to decreased recognition of mis-folded proteins which eventually leads to decreased OH radical formation (PubMed 20005847). {ECO 0000269|PubMed 10972835, ECO 0000269|PubMed 11830644, ECO 0000269|PubMed 20005847, ECO 0000269|PubMed 2185221, ECO 0000269|PubMed 7883164, ECO 0000269|PubMed 9473036}. # DOMAIN CPXA_ECOLI The periplasmic segment (residues 30-163) defines the sensory domain (PubMed 9401031). Conformational changes in the cytoplasmic HAMP domain modulate the mobility of the central alpha-helices (which bend at Ser-238 and Pro-253) that allows formation of 1 kinase-active state. {ECO 0000269|PubMed 24492262, ECO 0000269|PubMed 9401031}. # ENZYME REGULATION CPXA_ECOLI The two-component system is activated by envelope stress such as overexpression of some (misfolded) periplasmic proteins (PubMed 7883164, PubMed 9351822). Activated by spheroplasting (which removes the periplasm) in an autoregulatory cpxA-cpxR-dependent fashion (PubMed 10972835). Cpx two-component system is induced at pH 8.0; in a degP deletion mutant induction is halved (PubMed 9473036, PubMed 16166523). The kinase activity is inhibited by periplasmic accessory protein CpxP; proteolysis of CpxP relieves inhibition (PubMed 16166523, PubMed 17259177, PubMed 25207645). Autokinase activity reconstituted in liposomes is 50% inhibited by periplasmic accessory protein CpxP, but CpxP has no effect on phosphatase activity; autokinase stimulated by KCl, NH(4)Cl, RbCl, pH 7.5 and 8.0, inhibited by sensor kinase inhibitors tetrachlorosalicylanilid and ethodin (PubMed 17259177). {ECO 0000269|PubMed 10972835, ECO 0000269|PubMed 16166523, ECO 0000269|PubMed 17259177, ECO 0000269|PubMed 25207645, ECO 0000269|PubMed 7883164, ECO 0000269|PubMed 9351822, ECO 0000269|PubMed 9473036}. # EcoGene EG10163 cpxA # FUNCTION CPXA_ECOLI Histidine kinase member of the two-component regulatory system CpxA/CpxR which responds to envelope stress response by activating expression of downstream genes including cpxP, degP, dsbA and ppiA (PubMed 7883164, PubMed 9401031, PubMed 9473036). Activates CpxR by phosphorylation; has autokinase, phosphotransferase and (in the presence of Mg(2+) and/or ATP or ADP) phosphatase activity (PubMed 9401031, PubMed 17259177, PubMed 24492262). The kinase activity is inhibited by periplasmic accessory protein CpxP; proteolysis of CpxP relieves inhibition (PubMed 16166523, PubMed 17259177, PubMed 25207645). Involved in several diverse cellular processes, including the functioning of acetohydroxyacid synthetase I, the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid (PubMed 8432716), and the synthesis, translocation, or stability of cell envelope proteins (PubMed 7883164). Activates transcription of periplasmic protease degP, probably by phosphorylating the cognate response protein CpxR; overexpression of an outer membrane lipoprotein NlpE also leads to transcription of degP via CpxRA (PubMed 7883164). Required for efficient binding of stationary phase cells to hydrophobic surfaces, part of the process of biofilm formation (PubMed 11830644). {ECO 0000269|PubMed 16166523, ECO 0000269|PubMed 17259177, ECO 0000269|PubMed 24492262, ECO 0000269|PubMed 25207645, ECO 0000269|PubMed 7883164, ECO 0000269|PubMed 8432716, ECO 0000269|PubMed 9401031, ECO 0000269|PubMed 9473036, ECO 0000305|PubMed 11830644}. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IDA:EcoCyc. # GO_function GO:0000155 phosphorelay sensor kinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0000160 phosphorelay signal transduction system; IDA:EcoCyc. # GO_process GO:0043708 cell adhesion involved in biofilm formation; IMP:CACAO. # GO_process GO:0046777 protein autophosphorylation; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005622 intracellular # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0007155 cell adhesion # GOslim_process GO:0007165 signal transduction # Gene3D 1.10.287.130 -; 1. # Gene3D 3.30.565.10 -; 1. # INTERACTION CPXA_ECOLI P76086 paaX; NbExp=3; IntAct=EBI-9141330, EBI-544692; # IntAct P0AE82 2 # InterPro IPR003594 HATPase_C # InterPro IPR003660 HAMP_dom # InterPro IPR003661 HisK_dim/P # InterPro IPR004358 Sig_transdc_His_kin-like_C # InterPro IPR005467 His_kinase_dom # InterPro IPR032404 CpxA_peri # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01001 Protein kinases # KEGG_Brite ko02022 M00447 CpxA-CpxR (envelope stress response) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # Organism CPXA_ECOLI Escherichia coli (strain K12) # PATRIC 32123335 VBIEscCol129921_4028 # PDB 4BIU X-ray; 3.65 A; A/B/C/D/E/F=188-457 # PDB 4BIV X-ray; 3.40 A; A/B=188-457 # PDB 4BIW X-ray; 2.85 A; A/B=188-457 # PDB 4BIX X-ray; 2.00 A; A/B=188-457 # PDB 4BIY X-ray; 3.30 A; A/B/C/D=188-457 # PDB 4BIZ X-ray; 2.65 A; A/B/C/D/E/F=188-457 # PDB 4CB0 X-ray; 3.30 A; A/B=188-457 # PIR S40855 S40855 # PRINTS PR00344 BCTRLSENSOR # PROSITE PS50109 HIS_KIN # PROSITE PS50885 HAMP # PTM CPXA_ECOLI Autophosphorylated (PubMed 9401031, PubMed 24492262). Maximal phosphorylation of the dimeric isolated cytoplasmic domain (residues 188-457) is about 70%, suggesting the protein may be hemiphosphorylated in vivo; probably occurs via a trans- autophosphorylation mechanism, i.e. one subunit phopshorylates the other (PubMed 24492262). {ECO 0000269|PubMed 24492262, ECO 0000269|PubMed 9401031}. # Pfam PF00512 HisKA # Pfam PF00672 HAMP # Pfam PF02518 HATPase_c # Pfam PF16527 CpxA_peri # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CPXA_ECOLI Sensor histidine kinase CpxA # RefSeq NP_418347 NC_000913.3 # RefSeq WP_000580417 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA72540.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Contains 1 HAMP domain. {ECO:0000255|PROSITE- ProRule PRU00102}. # SIMILARITY Contains 1 histidine kinase domain. {ECO:0000255|PROSITE-ProRule PRU00107}. # SMART SM00304 HAMP # SMART SM00387 HATPase_c # SMART SM00388 HisKA # SUBCELLULAR LOCATION CPXA_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 25207645, ECO 0000269|PubMed 3058985}; Multi-pass membrane protein {ECO 0000305|PubMed 15919996, ECO 0000305|PubMed 3058985}. # SUBUNIT CPXA_ECOLI The isolated cytoplasmic domain (residues 188-457) crystallizes as a homodimer, and forms dimers of dimers in solution which may be catalytically important (PubMed 24492262). Interacts with periplasmic accessory protein CpxP (PubMed 16166523, PubMed 21317318, PubMed 21239493, PubMed 25207645); interaction with CpxP is not seen in vivo when cells are grown in 0.3 M NaCl, or if the misfolded P pili protein PapE is overexpressed (PubMed 25207645). Interacts with cognate response regulator CpxR (PubMed 25207645). {ECO 0000269|PubMed 24492262, ECO 0000269|PubMed 25207645, ECO 0000305|PubMed 16166523}. # SUPFAM SSF47384 SSF47384 # SUPFAM SSF55874 SSF55874 # eggNOG ENOG4105E0F Bacteria # eggNOG ENOG410XTWD LUCA BLAST swissprot:CPXA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CPXA_ECOLI BioCyc ECOL316407:JW3882-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3882-MONOMER BioCyc EcoCyc:CPXA-MONOMER http://biocyc.org/getid?id=EcoCyc:CPXA-MONOMER COG COG0642 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0642 DIP DIP-48358N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48358N DOI 10.1016/0022-2836(88)90013-7 http://dx.doi.org/10.1016/0022-2836(88)90013-7 DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2000.02074.x http://dx.doi.org/10.1046/j.1365-2958.2000.02074.x DOI 10.1073/pnas.042521699 http://dx.doi.org/10.1073/pnas.042521699 DOI 10.1074/jbc.M110.194092 http://dx.doi.org/10.1074/jbc.M110.194092 DOI 10.1074/jbc.M605785200 http://dx.doi.org/10.1074/jbc.M605785200 DOI 10.1093/emboj/16.21.6394 http://dx.doi.org/10.1093/emboj/16.21.6394 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1101/gad.9.4.387 http://dx.doi.org/10.1101/gad.9.4.387 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01296-10 http://dx.doi.org/10.1128/JB.01296-10 DOI 10.1128/JB.187.19.6622-6630.2005 http://dx.doi.org/10.1128/JB.187.19.6622-6630.2005 DOI 10.1371/journal.pbio.1001776 http://dx.doi.org/10.1371/journal.pbio.1001776 DOI 10.1371/journal.pone.0107383 http://dx.doi.org/10.1371/journal.pone.0107383 EC_number EC:2.7.13.3 {ECO:0000269|PubMed:9401031} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.13.3 {ECO:0000269|PubMed:9401031} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL M13493 http://www.ebi.ac.uk/ena/data/view/M13493 EMBL M36795 http://www.ebi.ac.uk/ena/data/view/M36795 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X13307 http://www.ebi.ac.uk/ena/data/view/X13307 ENZYME 2.7.13.3 {ECO:0000269|PubMed:9401031} http://enzyme.expasy.org/EC/2.7.13.3 {ECO:0000269|PubMed:9401031} EchoBASE EB0161 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0161 EcoGene EG10163 http://www.ecogene.org/geneInfo.php?eg_id=EG10163 EnsemblBacteria AAC76893 http://www.ensemblgenomes.org/id/AAC76893 EnsemblBacteria AAC76893 http://www.ensemblgenomes.org/id/AAC76893 EnsemblBacteria BAE77398 http://www.ensemblgenomes.org/id/BAE77398 EnsemblBacteria BAE77398 http://www.ensemblgenomes.org/id/BAE77398 EnsemblBacteria BAE77398 http://www.ensemblgenomes.org/id/BAE77398 EnsemblBacteria b3911 http://www.ensemblgenomes.org/id/b3911 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0000155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000155 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0043708 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043708 GO_process GO:0046777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046777 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 Gene3D 1.10.287.130 http://www.cathdb.info/version/latest/superfamily/1.10.287.130 Gene3D 3.30.565.10 http://www.cathdb.info/version/latest/superfamily/3.30.565.10 GeneID 948405 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948405 HOGENOM HOG000269851 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000269851&db=HOGENOM6 InParanoid P0AE82 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AE82 IntAct P0AE82 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AE82* IntEnz 2.7.13.3 {ECO:0000269|PubMed:9401031} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.13.3 {ECO:0000269|PubMed:9401031} InterPro IPR003594 http://www.ebi.ac.uk/interpro/entry/IPR003594 InterPro IPR003660 http://www.ebi.ac.uk/interpro/entry/IPR003660 InterPro IPR003661 http://www.ebi.ac.uk/interpro/entry/IPR003661 InterPro IPR004358 http://www.ebi.ac.uk/interpro/entry/IPR004358 InterPro IPR005467 http://www.ebi.ac.uk/interpro/entry/IPR005467 InterPro IPR032404 http://www.ebi.ac.uk/interpro/entry/IPR032404 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01001 http://www.genome.jp/dbget-bin/www_bget?ko01001 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW3882 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3882 KEGG_Gene eco:b3911 http://www.genome.jp/dbget-bin/www_bget?eco:b3911 KEGG_Orthology KO:K07640 http://www.genome.jp/dbget-bin/www_bget?KO:K07640 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA IPVEKAC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IPVEKAC PDB 4BIU http://www.ebi.ac.uk/pdbe-srv/view/entry/4BIU PDB 4BIV http://www.ebi.ac.uk/pdbe-srv/view/entry/4BIV PDB 4BIW http://www.ebi.ac.uk/pdbe-srv/view/entry/4BIW PDB 4BIX http://www.ebi.ac.uk/pdbe-srv/view/entry/4BIX PDB 4BIY http://www.ebi.ac.uk/pdbe-srv/view/entry/4BIY PDB 4BIZ http://www.ebi.ac.uk/pdbe-srv/view/entry/4BIZ PDB 4CB0 http://www.ebi.ac.uk/pdbe-srv/view/entry/4CB0 PDBsum 4BIU http://www.ebi.ac.uk/pdbsum/4BIU PDBsum 4BIV http://www.ebi.ac.uk/pdbsum/4BIV PDBsum 4BIW http://www.ebi.ac.uk/pdbsum/4BIW PDBsum 4BIX http://www.ebi.ac.uk/pdbsum/4BIX PDBsum 4BIY http://www.ebi.ac.uk/pdbsum/4BIY PDBsum 4BIZ http://www.ebi.ac.uk/pdbsum/4BIZ PDBsum 4CB0 http://www.ebi.ac.uk/pdbsum/4CB0 PRINTS PR00344 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00344 PROSITE PS50109 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50109 PROSITE PS50885 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50885 PSORT swissprot:CPXA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CPXA_ECOLI PSORT-B swissprot:CPXA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CPXA_ECOLI PSORT2 swissprot:CPXA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CPXA_ECOLI Pfam PF00512 http://pfam.xfam.org/family/PF00512 Pfam PF00672 http://pfam.xfam.org/family/PF00672 Pfam PF02518 http://pfam.xfam.org/family/PF02518 Pfam PF16527 http://pfam.xfam.org/family/PF16527 Phobius swissprot:CPXA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CPXA_ECOLI PhylomeDB P0AE82 http://phylomedb.org/?seqid=P0AE82 ProteinModelPortal P0AE82 http://www.proteinmodelportal.org/query/uniprot/P0AE82 PubMed 10972835 http://www.ncbi.nlm.nih.gov/pubmed/10972835 PubMed 11830644 http://www.ncbi.nlm.nih.gov/pubmed/11830644 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16166523 http://www.ncbi.nlm.nih.gov/pubmed/16166523 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17259177 http://www.ncbi.nlm.nih.gov/pubmed/17259177 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 21239493 http://www.ncbi.nlm.nih.gov/pubmed/21239493 PubMed 21317318 http://www.ncbi.nlm.nih.gov/pubmed/21317318 PubMed 2185221 http://www.ncbi.nlm.nih.gov/pubmed/2185221 PubMed 24492262 http://www.ncbi.nlm.nih.gov/pubmed/24492262 PubMed 25207645 http://www.ncbi.nlm.nih.gov/pubmed/25207645 PubMed 3007473 http://www.ncbi.nlm.nih.gov/pubmed/3007473 PubMed 3058985 http://www.ncbi.nlm.nih.gov/pubmed/3058985 PubMed 7883164 http://www.ncbi.nlm.nih.gov/pubmed/7883164 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 8432716 http://www.ncbi.nlm.nih.gov/pubmed/8432716 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9351822 http://www.ncbi.nlm.nih.gov/pubmed/9351822 PubMed 9401031 http://www.ncbi.nlm.nih.gov/pubmed/9401031 PubMed 9473036 http://www.ncbi.nlm.nih.gov/pubmed/9473036 RefSeq NP_418347 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418347 RefSeq WP_000580417 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000580417 SMART SM00304 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00304 SMART SM00387 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00387 SMART SM00388 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00388 SMR P0AE82 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AE82 STRING 511145.b3911 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3911&targetmode=cogs STRING COG0642 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0642&targetmode=cogs SUPFAM SSF47384 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47384 SUPFAM SSF55874 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55874 UniProtKB CPXA_ECOLI http://www.uniprot.org/uniprot/CPXA_ECOLI UniProtKB-AC P0AE82 http://www.uniprot.org/uniprot/P0AE82 charge swissprot:CPXA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CPXA_ECOLI eggNOG ENOG4105E0F http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E0F eggNOG ENOG410XTWD http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XTWD epestfind swissprot:CPXA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CPXA_ECOLI garnier swissprot:CPXA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CPXA_ECOLI helixturnhelix swissprot:CPXA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CPXA_ECOLI hmoment swissprot:CPXA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CPXA_ECOLI iep swissprot:CPXA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CPXA_ECOLI inforesidue swissprot:CPXA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CPXA_ECOLI octanol swissprot:CPXA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CPXA_ECOLI pepcoil swissprot:CPXA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CPXA_ECOLI pepdigest swissprot:CPXA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CPXA_ECOLI pepinfo swissprot:CPXA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CPXA_ECOLI pepnet swissprot:CPXA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CPXA_ECOLI pepstats swissprot:CPXA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CPXA_ECOLI pepwheel swissprot:CPXA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CPXA_ECOLI pepwindow swissprot:CPXA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CPXA_ECOLI sigcleave swissprot:CPXA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CPXA_ECOLI ## Database ID URL or Descriptions # AltName Molybdenum cofactor biosynthesis protein A {ECO:0000255|HAMAP-Rule MF_01225} # BioGrid 4259951 5 # CATALYTIC ACTIVITY GTP + S-adenosyl-L-methionine + reduced electron acceptor = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'- triphosphate + 5'-deoxyadenosine + L-methionine + oxidized electron acceptor. {ECO:0000255|HAMAP-Rule MF_01225}. # COFACTOR MOAA_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000255|HAMAP-Rule MF_01225}; Note=Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L- methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate. {ECO 0000255|HAMAP-Rule MF_01225}; # EcoGene EG11595 moaA # FUNCTION MOAA_ECOLI Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. {ECO 0000255|HAMAP- Rule MF_01225}. # FUNCTION MOAA_ECOLI Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z). # GO_component GO:0019008 molybdopterin synthase complex; IEA:InterPro. # GO_function GO:0005525 GTP binding; IEA:UniProtKB-KW. # GO_function GO:0016829 lyase activity; IEA:UniProtKB-KW. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0006777 Mo-molybdopterin cofactor biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0009408 response to heat; IMP:EcoCyc. # GO_process GO:0032324 molybdopterin cofactor biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.20.20.70 -; 1. # HAMAP MF_01225_B MoaA_B # INDUCTION MOAA_ECOLI By anaerobiosis, repressed by the molybdenum cofactor. # IntAct P30745 13 # InterPro IPR000385 MoaA_NifB_PqqE_Fe-S-bd_CS # InterPro IPR006638 Elp3/MiaB/NifB # InterPro IPR007197 rSAM # InterPro IPR010505 Mob_synth_C # InterPro IPR013483 MoaA # InterPro IPR013785 Aldolase_TIM # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko00790 Folate biosynthesis # KEGG_Pathway ko04122 Sulfur relay system # Organism MOAA_ECOLI Escherichia coli (strain K12) # PATHWAY Cofactor biosynthesis; molybdopterin biosynthesis. {ECO:0000255|HAMAP-Rule MF_01225}. # PATRIC 32116763 VBIEscCol129921_0807 # PIR S31879 S31879 # PROSITE PS01305 MOAA_NIFB_PQQE # Pfam PF04055 Radical_SAM # Pfam PF06463 Mob_synth_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GTP 3',8-cyclase {ECO:0000255|HAMAP-Rule MF_01225} # RefSeq NP_415302 NC_000913.3 # RefSeq WP_001350494 NZ_LN832404.1 # SIMILARITY Belongs to the radical SAM superfamily. MoaA family. {ECO:0000255|HAMAP-Rule MF_01225}. # SMART SM00729 Elp3 # SUBUNIT Monomer and homodimer. {ECO:0000255|HAMAP-Rule MF_01225}. # TIGRFAMs TIGR02666 moaA # eggNOG COG2896 LUCA # eggNOG ENOG4105CM1 Bacteria BLAST swissprot:MOAA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MOAA_ECOLI BioCyc ECOL316407:JW0764-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0764-MONOMER BioCyc EcoCyc:EG11595-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11595-MONOMER BioCyc MetaCyc:EG11595-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11595-MONOMER COG COG2896 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2896 DIP DIP-10228N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10228N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1993.tb01652.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb01652.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.1.99.22 {ECO:0000255|HAMAP-Rule:MF_01225} http://www.genome.jp/dbget-bin/www_bget?EC:4.1.99.22 {ECO:0000255|HAMAP-Rule:MF_01225} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X70420 http://www.ebi.ac.uk/ena/data/view/X70420 ENZYME 4.1.99.22 {ECO:0000255|HAMAP-Rule:MF_01225} http://enzyme.expasy.org/EC/4.1.99.22 {ECO:0000255|HAMAP-Rule:MF_01225} EchoBASE EB1552 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1552 EcoGene EG11595 http://www.ecogene.org/geneInfo.php?eg_id=EG11595 EnsemblBacteria AAC73868 http://www.ensemblgenomes.org/id/AAC73868 EnsemblBacteria AAC73868 http://www.ensemblgenomes.org/id/AAC73868 EnsemblBacteria BAA35439 http://www.ensemblgenomes.org/id/BAA35439 EnsemblBacteria BAA35439 http://www.ensemblgenomes.org/id/BAA35439 EnsemblBacteria BAA35439 http://www.ensemblgenomes.org/id/BAA35439 EnsemblBacteria b0781 http://www.ensemblgenomes.org/id/b0781 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0019008 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019008 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0006777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006777 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GO_process GO:0032324 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032324 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 945392 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945392 HAMAP MF_01225_B http://hamap.expasy.org/unirule/MF_01225_B HOGENOM HOG000228682 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000228682&db=HOGENOM6 InParanoid P30745 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30745 IntAct P30745 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P30745* IntEnz 4.1.99.22 {ECO:0000255|HAMAP-Rule:MF_01225} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.99.22 {ECO:0000255|HAMAP-Rule:MF_01225} InterPro IPR000385 http://www.ebi.ac.uk/interpro/entry/IPR000385 InterPro IPR006638 http://www.ebi.ac.uk/interpro/entry/IPR006638 InterPro IPR007197 http://www.ebi.ac.uk/interpro/entry/IPR007197 InterPro IPR010505 http://www.ebi.ac.uk/interpro/entry/IPR010505 InterPro IPR013483 http://www.ebi.ac.uk/interpro/entry/IPR013483 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW0764 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0764 KEGG_Gene eco:b0781 http://www.genome.jp/dbget-bin/www_bget?eco:b0781 KEGG_Orthology KO:K03639 http://www.genome.jp/dbget-bin/www_bget?KO:K03639 KEGG_Pathway ko00790 http://www.genome.jp/kegg-bin/show_pathway?ko00790 KEGG_Pathway ko04122 http://www.genome.jp/kegg-bin/show_pathway?ko04122 KEGG_Reaction rn:R09394 http://www.genome.jp/dbget-bin/www_bget?rn:R09394 MINT MINT-1229909 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1229909 OMA GWIHQIR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GWIHQIR PROSITE PS01305 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01305 PSORT swissprot:MOAA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MOAA_ECOLI PSORT-B swissprot:MOAA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MOAA_ECOLI PSORT2 swissprot:MOAA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MOAA_ECOLI Pfam PF04055 http://pfam.xfam.org/family/PF04055 Pfam PF06463 http://pfam.xfam.org/family/PF06463 Phobius swissprot:MOAA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MOAA_ECOLI PhylomeDB P30745 http://phylomedb.org/?seqid=P30745 ProteinModelPortal P30745 http://www.proteinmodelportal.org/query/uniprot/P30745 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8361352 http://www.ncbi.nlm.nih.gov/pubmed/8361352 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415302 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415302 RefSeq WP_001350494 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001350494 SMART SM00729 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00729 SMR P30745 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P30745 STRING 511145.b0781 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0781&targetmode=cogs STRING COG2896 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2896&targetmode=cogs TIGRFAMs TIGR02666 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02666 UniProtKB MOAA_ECOLI http://www.uniprot.org/uniprot/MOAA_ECOLI UniProtKB-AC P30745 http://www.uniprot.org/uniprot/P30745 charge swissprot:MOAA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MOAA_ECOLI eggNOG COG2896 http://eggnogapi.embl.de/nog_data/html/tree/COG2896 eggNOG ENOG4105CM1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CM1 epestfind swissprot:MOAA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MOAA_ECOLI garnier swissprot:MOAA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MOAA_ECOLI helixturnhelix swissprot:MOAA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MOAA_ECOLI hmoment swissprot:MOAA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MOAA_ECOLI iep swissprot:MOAA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MOAA_ECOLI inforesidue swissprot:MOAA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MOAA_ECOLI octanol swissprot:MOAA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MOAA_ECOLI pepcoil swissprot:MOAA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MOAA_ECOLI pepdigest swissprot:MOAA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MOAA_ECOLI pepinfo swissprot:MOAA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MOAA_ECOLI pepnet swissprot:MOAA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MOAA_ECOLI pepstats swissprot:MOAA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MOAA_ECOLI pepwheel swissprot:MOAA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MOAA_ECOLI pepwindow swissprot:MOAA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MOAA_ECOLI sigcleave swissprot:MOAA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MOAA_ECOLI ## Database ID URL or Descriptions # AltName PTIBC_ECOLI EIIBC-Asc # AltName PTIBC_ECOLI PTS system arbutin-, cellobiose-, and salicin-specific EIIB component # AltName PTIBC_ECOLI PTS system arbutin-, cellobiose-, and salicin-specific EIIB component # AltName PTIBC_ECOLI PTS system arbutin-, cellobiose-, and salicin-specific EIIC component # BioGrid 4261308 9 # CATALYTIC ACTIVITY Protein EIIB N(pi)-phospho-L- histidine/cysteine + sugar = protein EIIB + sugar phosphate. {ECO:0000255|PROSITE-ProRule PRU00421}. # CDD cd00212 PTS_IIB_glc # DOMAIN PTIBC_ECOLI The EIIB domain is phosphorylated by phospho-EIIA on a cysteinyl or histidyl residue, depending on the transported sugar. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the EIIC domain. # DOMAIN PTIBC_ECOLI The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site. # EcoGene EG10086 ascF # FUNCTION PTIBC_ECOLI The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in arbutin, cellobiose, and salicin transport. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0008982 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:InterPro. # GO_function GO:0016301 kinase activity; IEA:UniProtKB-KW. # GO_function GO:0090563 protein-phosphocysteine-sugar phosphotransferase activity; IBA:GO_Central. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IBA:GO_Central. # GO_process GO:0034219 carbohydrate transmembrane transport; IBA:GO_Central. # GO_process GO:0043610 regulation of carbohydrate utilization; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # GOslim_process GO:0055085 transmembrane transport # Gene3D 3.30.1360.60 -; 1. # InterPro IPR001996 PTS_IIB_1 # InterPro IPR003352 PTS_EIIC # InterPro IPR004719 PTS_maltose/Glc_sub_IIC # InterPro IPR013013 PTS_EIIC_1 # InterPro IPR018113 PTrfase_EIIB_Cys # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00272 PTS system, arbutin-, cellobiose-, and salicin-specific II component # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko00010 Glycolysis / Gluconeogenesis # KEGG_Pathway ko02060 Phosphotransferase system (PTS) # Organism PTIBC_ECOLI Escherichia coli (strain K12) # PATRIC 32120830 VBIEscCol129921_2807 # PIR G65051 G65051 # PROSITE PS01035 PTS_EIIB_TYPE_1_CYS # PROSITE PS51098 PTS_EIIB_TYPE_1 # PROSITE PS51103 PTS_EIIC_TYPE_1 # Pfam PF00367 PTS_EIIB # Pfam PF02378 PTS_EIIC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PTIBC_ECOLI Arbutin, cellobiose, and salicin permease IIC component # RecName PTIBC_ECOLI Arbutin-, cellobiose-, and salicin-specific phosphotransferase enzyme IIB component # RecName PTIBC_ECOLI PTS system arbutin-, cellobiose-, and salicin-specific EIIBC component # RefSeq WP_001107828 NZ_LN832404.1 # RefSeq YP_026182 NC_000913.3 # SIMILARITY Contains 1 PTS EIIB type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00421}. # SIMILARITY Contains 1 PTS EIIC type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00426}. # SUBCELLULAR LOCATION PTIBC_ECOLI Cell inner membrane {ECO 0000255|PROSITE- ProRule PRU00426, ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00426, ECO 0000269|PubMed 15919996}. # SUPFAM SSF55604 SSF55604 # TCDB 4.A.1.2 the pts glucose-glucoside (glc) family # TIGRFAMs TIGR00852 pts-Glc # eggNOG COG1263 LUCA # eggNOG COG1264 LUCA # eggNOG ENOG4105C5Y Bacteria BLAST swissprot:PTIBC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTIBC_ECOLI BioCyc ECOL316407:JW5435-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5435-MONOMER BioCyc EcoCyc:ASCF-MONOMER http://biocyc.org/getid?id=EcoCyc:ASCF-MONOMER BioCyc MetaCyc:ASCF-MONOMER http://biocyc.org/getid?id=MetaCyc:ASCF-MONOMER COG COG1263 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1263 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M73326 http://www.ebi.ac.uk/ena/data/view/M73326 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 ENZYME 2.7.1.- http://enzyme.expasy.org/EC/2.7.1.- EchoBASE EB0084 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0084 EcoGene EG10086 http://www.ecogene.org/geneInfo.php?eg_id=EG10086 EnsemblBacteria AAT48150 http://www.ensemblgenomes.org/id/AAT48150 EnsemblBacteria AAT48150 http://www.ensemblgenomes.org/id/AAT48150 EnsemblBacteria BAE76792 http://www.ensemblgenomes.org/id/BAE76792 EnsemblBacteria BAE76792 http://www.ensemblgenomes.org/id/BAE76792 EnsemblBacteria BAE76792 http://www.ensemblgenomes.org/id/BAE76792 EnsemblBacteria b2715 http://www.ensemblgenomes.org/id/b2715 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008982 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008982 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_function GO:0090563 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090563 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GO_process GO:0034219 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034219 GO_process GO:0043610 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043610 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 3.30.1360.60 http://www.cathdb.info/version/latest/superfamily/3.30.1360.60 GeneID 947154 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947154 HOGENOM HOG000102023 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000102023&db=HOGENOM6 IntEnz 2.7.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1 InterPro IPR001996 http://www.ebi.ac.uk/interpro/entry/IPR001996 InterPro IPR003352 http://www.ebi.ac.uk/interpro/entry/IPR003352 InterPro IPR004719 http://www.ebi.ac.uk/interpro/entry/IPR004719 InterPro IPR013013 http://www.ebi.ac.uk/interpro/entry/IPR013013 InterPro IPR018113 http://www.ebi.ac.uk/interpro/entry/IPR018113 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5435 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5435 KEGG_Gene eco:b2715 http://www.genome.jp/dbget-bin/www_bget?eco:b2715 KEGG_Orthology KO:K02753 http://www.genome.jp/dbget-bin/www_bget?KO:K02753 KEGG_Pathway ko00010 http://www.genome.jp/kegg-bin/show_pathway?ko00010 KEGG_Pathway ko02060 http://www.genome.jp/kegg-bin/show_pathway?ko02060 KEGG_Reaction rn:R04394 http://www.genome.jp/dbget-bin/www_bget?rn:R04394 KEGG_Reaction rn:R05132 http://www.genome.jp/dbget-bin/www_bget?rn:R05132 OMA ILTVIGD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ILTVIGD PROSITE PS01035 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01035 PROSITE PS51098 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51098 PROSITE PS51103 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51103 PSORT swissprot:PTIBC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTIBC_ECOLI PSORT-B swissprot:PTIBC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTIBC_ECOLI PSORT2 swissprot:PTIBC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTIBC_ECOLI Pfam PF00367 http://pfam.xfam.org/family/PF00367 Pfam PF02378 http://pfam.xfam.org/family/PF02378 Phobius swissprot:PTIBC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTIBC_ECOLI PhylomeDB P24241 http://phylomedb.org/?seqid=P24241 ProteinModelPortal P24241 http://www.proteinmodelportal.org/query/uniprot/P24241 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 1630307 http://www.ncbi.nlm.nih.gov/pubmed/1630307 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001107828 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001107828 RefSeq YP_026182 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026182 SMR P24241 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P24241 STRING 511145.b2715 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2715&targetmode=cogs STRING COG1263 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1263&targetmode=cogs SUPFAM SSF55604 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55604 TCDB 4.A.1.2 http://www.tcdb.org/search/result.php?tc=4.A.1.2 TIGRFAMs TIGR00852 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00852 UniProtKB PTIBC_ECOLI http://www.uniprot.org/uniprot/PTIBC_ECOLI UniProtKB-AC P24241 http://www.uniprot.org/uniprot/P24241 charge swissprot:PTIBC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTIBC_ECOLI eggNOG COG1263 http://eggnogapi.embl.de/nog_data/html/tree/COG1263 eggNOG COG1264 http://eggnogapi.embl.de/nog_data/html/tree/COG1264 eggNOG ENOG4105C5Y http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C5Y epestfind swissprot:PTIBC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTIBC_ECOLI garnier swissprot:PTIBC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTIBC_ECOLI helixturnhelix swissprot:PTIBC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTIBC_ECOLI hmoment swissprot:PTIBC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTIBC_ECOLI iep swissprot:PTIBC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTIBC_ECOLI inforesidue swissprot:PTIBC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTIBC_ECOLI octanol swissprot:PTIBC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTIBC_ECOLI pepcoil swissprot:PTIBC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTIBC_ECOLI pepdigest swissprot:PTIBC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTIBC_ECOLI pepinfo swissprot:PTIBC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTIBC_ECOLI pepnet swissprot:PTIBC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTIBC_ECOLI pepstats swissprot:PTIBC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTIBC_ECOLI pepwheel swissprot:PTIBC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTIBC_ECOLI pepwindow swissprot:PTIBC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTIBC_ECOLI sigcleave swissprot:PTIBC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTIBC_ECOLI ## Database ID URL or Descriptions # BioGrid 4263055 355 # DISRUPTION PHENOTYPE Disruption of tatA affects the correct localization of multiple enzymes whose precursors bear twin arginine transfer peptides. Export is completely blocked when both tatA and tatE are inactivated. {ECO:0000269|PubMed 9649434}. # EcoGene EG11478 tatA # FUNCTION TATA_ECOLI Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. {ECO 0000255|HAMAP-Rule MF_00236, ECO 0000269|PubMed 11922668, ECO 0000269|PubMed 9649434}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IDA:EcoliWiki. # GO_component GO:0033281 TAT protein transport complex; IDA:EcoCyc. # GO_function GO:0008565 protein transporter activity; IGI:EcoliWiki. # GO_function GO:0009977 proton motive force dependent protein transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0009306 protein secretion; IEA:InterPro. # GO_process GO:0043953 protein transport by the Tat complex; IDA:EcoCyc. # GO_process GO:0065002 intracellular protein transmembrane transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008565 protein transporter activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # HAMAP MF_00236 TatA_E # INDUCTION Constitutively expressed. TatA is the most highly expressed of the tat genes. {ECO:0000269|PubMed 11160116}. # IntAct P69428 2 # InterPro IPR003369 TatA/B/E # InterPro IPR006312 TatA/E # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02044 M00336 Twin-arginine translocation (Tat) system # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko03060 Protein export # KEGG_Pathway ko03070 Bacterial secretion system # MISCELLANEOUS TATA_ECOLI Absence of TatA from the TatBC complex leads to the instability of the complex and the specific breakdown of TatB. # MISCELLANEOUS TATA_ECOLI TatA forms a transmembrane channel with a lid structure on the cytoplasmic side. The number of TatA protomers can vary so that the channel can adopt different diameters to accommodate substrates of various sizes. This enables TatA to pack tightly around substrate and prevents ion leakage during transport. # Organism TATA_ECOLI Escherichia coli (strain K12) # PATRIC 32123173 VBIEscCol129921_3952 # PDB 2LZR NMR; -; A=1-49 # PDB 2LZS NMR; -; A/B/C/D/E/F/G/H/I=1-49 # PDB 2MN6 NMR; -; A/B=1-89 # PDB 2MN7 NMR; -; A=1-89 # PIR E65188 E65188 # PIR S30727 S30727 # Pfam PF02416 MttA_Hcf106 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Sec-independent protein translocase protein TatA {ECO:0000255|HAMAP-Rule MF_00236} # RefSeq NP_418280 NC_000913.3 # RefSeq WP_001295260 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA67633.1; Type=Frameshift; Positions=11, 82, 88; Evidence={ECO:0000305}; Sequence=AAC19240.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the TatA/E family. {ECO:0000255|HAMAP- Rule MF_00236}. # SUBCELLULAR LOCATION TATA_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_00236, ECO 0000269|PubMed 11591389, ECO 0000269|PubMed 15225613, ECO 0000269|PubMed 20169075}; Single- pass membrane protein {ECO 0000255|HAMAP-Rule MF_00236, ECO 0000269|PubMed 11591389, ECO 0000269|PubMed 15225613, ECO 0000269|PubMed 20169075}; Cytoplasmic side {ECO 0000269|PubMed 11591389, ECO 0000269|PubMed 15225613, ECO 0000269|PubMed 20169075}. Note=Abundant all over the membrane, but is more concentrated at the cell poles. # SUBUNIT TATA_ECOLI The Tat system comprises two distinct complexes a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon. A complex containing only TatA and TatB has also been identified. It could be either an assembly intermediate or a disassembly intermediate generated during translocation activity. Each of TatA, TatB and TatC are able to interact in pairs without the third partner; TatA also forms homooligomers. {ECO 0000255|HAMAP-Rule MF_00236, ECO 0000269|PubMed 15225613, ECO 0000269|PubMed 15571732, ECO 0000269|PubMed 15663945, ECO 0000269|PubMed 17686475, ECO 0000269|PubMed 20169075}. # TCDB 2.A.64.1 the twin arginine targeting (tat) family # TIGRFAMs TIGR01411 tatAE # eggNOG COG1826 LUCA # eggNOG ENOG4105WKS Bacteria BLAST swissprot:TATA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TATA_ECOLI BioCyc ECOL316407:JW3813-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3813-MONOMER BioCyc EcoCyc:TATA http://biocyc.org/getid?id=EcoCyc:TATA BioCyc MetaCyc:TATA http://biocyc.org/getid?id=MetaCyc:TATA COG COG1826 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1826 DIP DIP-10958N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10958N DOI 10.1006/jmbi.2002.5431 http://dx.doi.org/10.1006/jmbi.2002.5431 DOI 10.1016/S0014-5793(01)02904-0 http://dx.doi.org/10.1016/S0014-5793(01)02904-0 DOI 10.1016/S0092-8674(00)81149-6 http://dx.doi.org/10.1016/S0092-8674(00)81149-6 DOI 10.1016/j.febslet.2004.05.054 http://dx.doi.org/10.1016/j.febslet.2004.05.054 DOI 10.1016/j.febslet.2007.07.044 http://dx.doi.org/10.1016/j.febslet.2007.07.044 DOI 10.1016/j.jmb.2004.10.043 http://dx.doi.org/10.1016/j.jmb.2004.10.043 DOI 10.1016/j.jmb.2004.11.047 http://dx.doi.org/10.1016/j.jmb.2004.11.047 DOI 10.1021/bi026142i http://dx.doi.org/10.1021/bi026142i DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2000.01719.x http://dx.doi.org/10.1046/j.1365-2958.2000.01719.x DOI 10.1046/j.1432-1327.2001.02263.x http://dx.doi.org/10.1046/j.1432-1327.2001.02263.x DOI 10.1073/pnas.0503558102 http://dx.doi.org/10.1073/pnas.0503558102 DOI 10.1074/jbc.M100682200 http://dx.doi.org/10.1074/jbc.M100682200 DOI 10.1093/emboj/17.13.3640 http://dx.doi.org/10.1093/emboj/17.13.3640 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.183.5.1801-1804.2001 http://dx.doi.org/10.1128/JB.183.5.1801-1804.2001 DOI 10.1371/journal.pone.0009225 http://dx.doi.org/10.1371/journal.pone.0009225 EMBL AF067848 http://www.ebi.ac.uk/ena/data/view/AF067848 EMBL AJ005830 http://www.ebi.ac.uk/ena/data/view/AJ005830 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG11478 http://www.ecogene.org/geneInfo.php?eg_id=EG11478 EnsemblBacteria AAC76839 http://www.ensemblgenomes.org/id/AAC76839 EnsemblBacteria AAC76839 http://www.ensemblgenomes.org/id/AAC76839 EnsemblBacteria BAE77465 http://www.ensemblgenomes.org/id/BAE77465 EnsemblBacteria BAE77465 http://www.ensemblgenomes.org/id/BAE77465 EnsemblBacteria BAE77465 http://www.ensemblgenomes.org/id/BAE77465 EnsemblBacteria b3836 http://www.ensemblgenomes.org/id/b3836 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0033281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033281 GO_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GO_function GO:0009977 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009977 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0009306 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009306 GO_process GO:0043953 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043953 GO_process GO:0065002 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0065002 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 948321 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948321 HAMAP MF_00236 http://hamap.expasy.org/unirule/MF_00236 HOGENOM HOG000245363 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000245363&db=HOGENOM6 InParanoid P69428 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P69428 IntAct P69428 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69428* InterPro IPR003369 http://www.ebi.ac.uk/interpro/entry/IPR003369 InterPro IPR006312 http://www.ebi.ac.uk/interpro/entry/IPR006312 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW3813 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3813 KEGG_Gene eco:b3836 http://www.genome.jp/dbget-bin/www_bget?eco:b3836 KEGG_Orthology KO:K03116 http://www.genome.jp/dbget-bin/www_bget?KO:K03116 KEGG_Pathway ko03060 http://www.genome.jp/kegg-bin/show_pathway?ko03060 KEGG_Pathway ko03070 http://www.genome.jp/kegg-bin/show_pathway?ko03070 MINT MINT-8083033 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8083033 OMA KEDAKRH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KEDAKRH PDB 2LZR http://www.ebi.ac.uk/pdbe-srv/view/entry/2LZR PDB 2LZS http://www.ebi.ac.uk/pdbe-srv/view/entry/2LZS PDB 2MN6 http://www.ebi.ac.uk/pdbe-srv/view/entry/2MN6 PDB 2MN7 http://www.ebi.ac.uk/pdbe-srv/view/entry/2MN7 PDBsum 2LZR http://www.ebi.ac.uk/pdbsum/2LZR PDBsum 2LZS http://www.ebi.ac.uk/pdbsum/2LZS PDBsum 2MN6 http://www.ebi.ac.uk/pdbsum/2MN6 PDBsum 2MN7 http://www.ebi.ac.uk/pdbsum/2MN7 PSORT swissprot:TATA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TATA_ECOLI PSORT-B swissprot:TATA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TATA_ECOLI PSORT2 swissprot:TATA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TATA_ECOLI Pfam PF02416 http://pfam.xfam.org/family/PF02416 Phobius swissprot:TATA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TATA_ECOLI PhylomeDB P69428 http://phylomedb.org/?seqid=P69428 ProteinModelPortal P69428 http://www.proteinmodelportal.org/query/uniprot/P69428 PubMed 10652088 http://www.ncbi.nlm.nih.gov/pubmed/10652088 PubMed 11160116 http://www.ncbi.nlm.nih.gov/pubmed/11160116 PubMed 11279240 http://www.ncbi.nlm.nih.gov/pubmed/11279240 PubMed 11422364 http://www.ncbi.nlm.nih.gov/pubmed/11422364 PubMed 11591389 http://www.ncbi.nlm.nih.gov/pubmed/11591389 PubMed 11922668 http://www.ncbi.nlm.nih.gov/pubmed/11922668 PubMed 12427031 http://www.ncbi.nlm.nih.gov/pubmed/12427031 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 15225613 http://www.ncbi.nlm.nih.gov/pubmed/15225613 PubMed 15571732 http://www.ncbi.nlm.nih.gov/pubmed/15571732 PubMed 15663945 http://www.ncbi.nlm.nih.gov/pubmed/15663945 PubMed 16027357 http://www.ncbi.nlm.nih.gov/pubmed/16027357 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17686475 http://www.ncbi.nlm.nih.gov/pubmed/17686475 PubMed 20169075 http://www.ncbi.nlm.nih.gov/pubmed/20169075 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9546395 http://www.ncbi.nlm.nih.gov/pubmed/9546395 PubMed 9649434 http://www.ncbi.nlm.nih.gov/pubmed/9649434 RefSeq NP_418280 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418280 RefSeq WP_001295260 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295260 SMR P69428 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69428 STRING 511145.b3836 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3836&targetmode=cogs STRING COG1826 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1826&targetmode=cogs TCDB 2.A.64.1 http://www.tcdb.org/search/result.php?tc=2.A.64.1 TIGRFAMs TIGR01411 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01411 UniProtKB TATA_ECOLI http://www.uniprot.org/uniprot/TATA_ECOLI UniProtKB-AC P69428 http://www.uniprot.org/uniprot/P69428 charge swissprot:TATA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TATA_ECOLI eggNOG COG1826 http://eggnogapi.embl.de/nog_data/html/tree/COG1826 eggNOG ENOG4105WKS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105WKS epestfind swissprot:TATA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TATA_ECOLI garnier swissprot:TATA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TATA_ECOLI helixturnhelix swissprot:TATA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TATA_ECOLI hmoment swissprot:TATA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TATA_ECOLI iep swissprot:TATA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TATA_ECOLI inforesidue swissprot:TATA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TATA_ECOLI octanol swissprot:TATA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TATA_ECOLI pepcoil swissprot:TATA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TATA_ECOLI pepdigest swissprot:TATA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TATA_ECOLI pepinfo swissprot:TATA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TATA_ECOLI pepnet swissprot:TATA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TATA_ECOLI pepstats swissprot:TATA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TATA_ECOLI pepwheel swissprot:TATA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TATA_ECOLI pepwindow swissprot:TATA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TATA_ECOLI sigcleave swissprot:TATA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TATA_ECOLI ## Database ID URL or Descriptions # AltName NARU_ECOLI Nitrite extrusion protein 2 # AltName NARU_ECOLI Nitrite facilitator 2 # BioGrid 4260180 13 # EcoGene EG12153 narU # FUNCTION NARU_ECOLI Catalyzes nitrate uptake, nitrite uptake and nitrite export across the cytoplasmic membrane. May function as a nitrate/H(+) and nitrite/H(+) channel. Could confer a selective advantage during severe nutrient starvation or slow growth. {ECO 0000269|PubMed 11967075, ECO 0000269|PubMed 15667293, ECO 0000269|PubMed 16804183, ECO 0000269|PubMed 18691156}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; ISM:EcoCyc. # GO_function GO:0015112 nitrate transmembrane transporter activity; IEA:InterPro. # GO_function GO:0015113 nitrite transmembrane transporter activity; IEA:InterPro. # GO_process GO:0042128 nitrate assimilation; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0071941 nitrogen cycle metabolic process # INDUCTION Expressed preferentially during the stationary phase in the absence of nitrate. {ECO:0000269|PubMed 16804183}. # InterPro IPR004737 NO3_transporter # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # KEGG_Brite ko02000 Transporters # Organism NARU_ECOLI Escherichia coli (strain K12) # PATRIC 32118230 VBIEscCol129921_1535 # PDB 4IU8 X-ray; 3.11 A; A/B=1-462 # PDB 4IU9 X-ray; 3.00 A; A/B=1-462 # PIR H64899 S11431 # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NARU_ECOLI Nitrate/nitrite transporter NarU # RefSeq NP_415986 NC_000913.3 # RefSeq WP_001207901 NZ_LN832404.1 # SIMILARITY Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family. {ECO 0000305}. # SUBCELLULAR LOCATION NARU_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 18691156}; Multi- pass membrane protein {ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 18691156}. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.8.10 the major facilitator superfamily (mfs) # TIGRFAMs TIGR00886 2A0108 # eggNOG COG2223 LUCA # eggNOG ENOG4107QND Bacteria BLAST swissprot:NARU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NARU_ECOLI BioCyc ECOL316407:JW1464-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1464-MONOMER BioCyc EcoCyc:NARU-MONOMER http://biocyc.org/getid?id=EcoCyc:NARU-MONOMER BioCyc MetaCyc:NARU-MONOMER http://biocyc.org/getid?id=MetaCyc:NARU-MONOMER COG COG2223 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2223 DOI 10.1007/BF00871632 http://dx.doi.org/10.1007/BF00871632 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/BJ20080746 http://dx.doi.org/10.1042/BJ20080746 DOI 10.1042/BST0330159 http://dx.doi.org/10.1042/BST0330159 DOI 10.1046/j.1365-2958.2002.02858.x http://dx.doi.org/10.1046/j.1365-2958.2002.02858.x DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1099/mic.0.28688-0 http://dx.doi.org/10.1099/mic.0.28688-0 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X17110 http://www.ebi.ac.uk/ena/data/view/X17110 EMBL X94992 http://www.ebi.ac.uk/ena/data/view/X94992 EchoBASE EB2073 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2073 EcoGene EG12153 http://www.ecogene.org/geneInfo.php?eg_id=EG12153 EnsemblBacteria AAD13433 http://www.ensemblgenomes.org/id/AAD13433 EnsemblBacteria AAD13433 http://www.ensemblgenomes.org/id/AAD13433 EnsemblBacteria BAA15118 http://www.ensemblgenomes.org/id/BAA15118 EnsemblBacteria BAA15118 http://www.ensemblgenomes.org/id/BAA15118 EnsemblBacteria BAA15118 http://www.ensemblgenomes.org/id/BAA15118 EnsemblBacteria b1469 http://www.ensemblgenomes.org/id/b1469 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015112 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015112 GO_function GO:0015113 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015113 GO_process GO:0042128 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042128 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0071941 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071941 GeneID 945799 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945799 HOGENOM HOG000241722 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000241722&db=HOGENOM6 InParanoid P37758 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37758 InterPro IPR004737 http://www.ebi.ac.uk/interpro/entry/IPR004737 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1464 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1464 KEGG_Gene eco:b1469 http://www.genome.jp/dbget-bin/www_bget?eco:b1469 KEGG_Orthology KO:K02575 http://www.genome.jp/dbget-bin/www_bget?KO:K02575 OMA CIWMVFS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CIWMVFS PDB 4IU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4IU8 PDB 4IU9 http://www.ebi.ac.uk/pdbe-srv/view/entry/4IU9 PDBsum 4IU8 http://www.ebi.ac.uk/pdbsum/4IU8 PDBsum 4IU9 http://www.ebi.ac.uk/pdbsum/4IU9 PSORT swissprot:NARU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NARU_ECOLI PSORT-B swissprot:NARU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NARU_ECOLI PSORT2 swissprot:NARU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NARU_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:NARU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NARU_ECOLI PhylomeDB P37758 http://phylomedb.org/?seqid=P37758 ProteinModelPortal P37758 http://www.proteinmodelportal.org/query/uniprot/P37758 PubMed 11967075 http://www.ncbi.nlm.nih.gov/pubmed/11967075 PubMed 15667293 http://www.ncbi.nlm.nih.gov/pubmed/15667293 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16804183 http://www.ncbi.nlm.nih.gov/pubmed/16804183 PubMed 18691156 http://www.ncbi.nlm.nih.gov/pubmed/18691156 PubMed 2233673 http://www.ncbi.nlm.nih.gov/pubmed/2233673 PubMed 7747940 http://www.ncbi.nlm.nih.gov/pubmed/7747940 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415986 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415986 RefSeq WP_001207901 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001207901 SMR P37758 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37758 STRING 511145.b1469 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1469&targetmode=cogs STRING COG2223 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2223&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.8.10 http://www.tcdb.org/search/result.php?tc=2.A.1.8.10 TIGRFAMs TIGR00886 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00886 UniProtKB NARU_ECOLI http://www.uniprot.org/uniprot/NARU_ECOLI UniProtKB-AC P37758 http://www.uniprot.org/uniprot/P37758 charge swissprot:NARU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NARU_ECOLI eggNOG COG2223 http://eggnogapi.embl.de/nog_data/html/tree/COG2223 eggNOG ENOG4107QND http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QND epestfind swissprot:NARU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NARU_ECOLI garnier swissprot:NARU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NARU_ECOLI helixturnhelix swissprot:NARU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NARU_ECOLI hmoment swissprot:NARU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NARU_ECOLI iep swissprot:NARU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NARU_ECOLI inforesidue swissprot:NARU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NARU_ECOLI octanol swissprot:NARU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NARU_ECOLI pepcoil swissprot:NARU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NARU_ECOLI pepdigest swissprot:NARU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NARU_ECOLI pepinfo swissprot:NARU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NARU_ECOLI pepnet swissprot:NARU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NARU_ECOLI pepstats swissprot:NARU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NARU_ECOLI pepwheel swissprot:NARU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NARU_ECOLI pepwindow swissprot:NARU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NARU_ECOLI sigcleave swissprot:NARU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NARU_ECOLI ## Database ID URL or Descriptions # BioGrid 4261697 6 # EcoGene EG13819 yneK # IntAct P76150 2 # Organism YNEK_ECOLI Escherichia coli (strain K12) # PATRIC 32118352 VBIEscCol129921_1596 # PIR B64907 B64907 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNEK_ECOLI Uncharacterized protein YneK # RefSeq NP_416044 NC_000913.3 # RefSeq WP_000258599 NZ_LN832404.1 BLAST swissprot:YNEK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNEK_ECOLI BioCyc ECOL316407:JW1520-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1520-MONOMER BioCyc EcoCyc:G6813-MONOMER http://biocyc.org/getid?id=EcoCyc:G6813-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3580 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3580 EcoGene EG13819 http://www.ecogene.org/geneInfo.php?eg_id=EG13819 EnsemblBacteria AAC74600 http://www.ensemblgenomes.org/id/AAC74600 EnsemblBacteria AAC74600 http://www.ensemblgenomes.org/id/AAC74600 EnsemblBacteria BAE76462 http://www.ensemblgenomes.org/id/BAE76462 EnsemblBacteria BAE76462 http://www.ensemblgenomes.org/id/BAE76462 EnsemblBacteria BAE76462 http://www.ensemblgenomes.org/id/BAE76462 EnsemblBacteria b1527 http://www.ensemblgenomes.org/id/b1527 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946080 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946080 HOGENOM HOG000009729 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009729&db=HOGENOM6 IntAct P76150 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76150* KEGG_Gene ecj:JW1520 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1520 KEGG_Gene eco:b1527 http://www.genome.jp/dbget-bin/www_bget?eco:b1527 OMA HIEPLHP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HIEPLHP PSORT swissprot:YNEK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNEK_ECOLI PSORT-B swissprot:YNEK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNEK_ECOLI PSORT2 swissprot:YNEK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNEK_ECOLI Phobius swissprot:YNEK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNEK_ECOLI ProteinModelPortal P76150 http://www.proteinmodelportal.org/query/uniprot/P76150 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416044 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416044 RefSeq WP_000258599 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000258599 STRING 511145.b1527 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1527&targetmode=cogs UniProtKB YNEK_ECOLI http://www.uniprot.org/uniprot/YNEK_ECOLI UniProtKB-AC P76150 http://www.uniprot.org/uniprot/P76150 charge swissprot:YNEK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNEK_ECOLI epestfind swissprot:YNEK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNEK_ECOLI garnier swissprot:YNEK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNEK_ECOLI helixturnhelix swissprot:YNEK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNEK_ECOLI hmoment swissprot:YNEK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNEK_ECOLI iep swissprot:YNEK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNEK_ECOLI inforesidue swissprot:YNEK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNEK_ECOLI octanol swissprot:YNEK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNEK_ECOLI pepcoil swissprot:YNEK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNEK_ECOLI pepdigest swissprot:YNEK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNEK_ECOLI pepinfo swissprot:YNEK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNEK_ECOLI pepnet swissprot:YNEK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNEK_ECOLI pepstats swissprot:YNEK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNEK_ECOLI pepwheel swissprot:YNEK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNEK_ECOLI pepwindow swissprot:YNEK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNEK_ECOLI sigcleave swissprot:YNEK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNEK_ECOLI ## Database ID URL or Descriptions # BioGrid 4259530 9 # DOMAIN RCSF_ECOLI Contains an N-terminal proline-rich region (PRR), which probably plays an important role in the regulation of function of RcsF and activation of the Rcs signaling system. {ECO 0000269|PubMed 23813676}. # EcoGene EG11502 rcsF # FUNCTION RCSF_ECOLI Essential component of the Rcs signaling system, which controls transcription of numerous genes. Plays a role in signal transduction from the cell surface to the histidine kinase RcsC. May detect outer membrane defects. The system controls expression of genes involved in colanic acid capsule synthesis, biofilm formation and cell division. {ECO 0000255|HAMAP-Rule MF_00976, ECO 0000269|PubMed 13129944, ECO 0000269|PubMed 14651646, ECO 0000269|PubMed 16166540, ECO 0000269|PubMed 16740933}. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_component GO:0031240 external side of cell outer membrane; IDA:EcoCyc. # GO_component GO:0031241 periplasmic side of cell outer membrane; IDA:EcoCyc. # GO_component GO:0036406 anchored component of periplasmic side of cell outer membrane; IEA:UniProtKB-HAMAP. # GO_process GO:0009242 colanic acid biosynthetic process; IMP:EcoCyc. # GO_process GO:0035556 intracellular signal transduction; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005622 intracellular # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0009058 biosynthetic process # HAMAP MF_00976 RcsF # INTERACTION RCSF_ECOLI P0A940 bamA; NbExp=3; IntAct=EBI-1114706, EBI-907371; P0A910 ompA; NbExp=3; IntAct=EBI-1114706, EBI-371347; # IntAct P69411 10 # InterPro IPR030852 RcsF # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko02020 Two-component system # MISCELLANEOUS The formation of the non-consecutive disulfides depends on the periplasmic disulfide isomerase DsbC. The disulfide bond between Cys-109 and Cys-124 is particularly important for the assembly of an active RcsF (PubMed:21454485). {ECO 0000305|PubMed:21454485}. # Organism RCSF_ECOLI Escherichia coli (strain K12) # PATRIC 32115505 VBIEscCol129921_0204 # PDB 2L8Y NMR; -; A=31-134 # PDB 2Y1B X-ray; 2.00 A; A=17-134 # PIR D64744 D64744 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF16358 RcsF # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Outer membrane lipoprotein RcsF {ECO:0000255|HAMAP-Rule MF_00976} # RefSeq NP_414738 NC_000913.3 # RefSeq WP_001202329 NZ_LN832404.1 # SIMILARITY Belongs to the RcsF family. {ECO:0000255|HAMAP- Rule MF_00976}. # SUBCELLULAR LOCATION RCSF_ECOLI Cell outer membrane {ECO 0000255|HAMAP- Rule MF_00976, ECO 0000269|PubMed 16740933, ECO 0000269|PubMed 23813676}; Lipid-anchor {ECO 0000255|HAMAP- Rule MF_00976, ECO 0000269|PubMed 16740933, ECO 0000269|PubMed 23813676}; Periplasmic side {ECO 0000255|HAMAP- Rule MF_00976, ECO 0000269|PubMed 16740933, ECO 0000269|PubMed 23813676}. # SUBUNIT Interacts with DsbC. {ECO:0000269|PubMed 21454485}. # eggNOG ENOG4108R8X Bacteria # eggNOG ENOG4111FP8 LUCA BLAST swissprot:RCSF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RCSF_ECOLI BioCyc ECOL316407:JW0192-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0192-MONOMER BioCyc EcoCyc:RCSF-MONOMER http://biocyc.org/getid?id=EcoCyc:RCSF-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2003.03815.x http://dx.doi.org/10.1046/j.1365-2958.2003.03815.x DOI 10.1074/jbc.M111.224865 http://dx.doi.org/10.1074/jbc.M111.224865 DOI 10.1074/jbc.M111.230185 http://dx.doi.org/10.1074/jbc.M111.230185 DOI 10.1099/mic.0.069328-0 http://dx.doi.org/10.1099/mic.0.069328-0 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00004-06 http://dx.doi.org/10.1128/JB.00004-06 DOI 10.1128/JB.185.19.5735-5746.2003 http://dx.doi.org/10.1128/JB.185.19.5735-5746.2003 DOI 10.1128/JB.187.19.6770-6778.2005 http://dx.doi.org/10.1128/JB.187.19.6770-6778.2005 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D15061 http://www.ebi.ac.uk/ena/data/view/D15061 EMBL L04474 http://www.ebi.ac.uk/ena/data/view/L04474 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EchoBASE EB1465 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1465 EcoGene EG11502 http://www.ecogene.org/geneInfo.php?eg_id=EG11502 EnsemblBacteria AAC73307 http://www.ensemblgenomes.org/id/AAC73307 EnsemblBacteria AAC73307 http://www.ensemblgenomes.org/id/AAC73307 EnsemblBacteria BAA77873 http://www.ensemblgenomes.org/id/BAA77873 EnsemblBacteria BAA77873 http://www.ensemblgenomes.org/id/BAA77873 EnsemblBacteria BAA77873 http://www.ensemblgenomes.org/id/BAA77873 EnsemblBacteria b0196 http://www.ensemblgenomes.org/id/b0196 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0031240 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031240 GO_component GO:0031241 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031241 GO_component GO:0036406 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036406 GO_process GO:0009242 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009242 GO_process GO:0035556 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035556 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 949113 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949113 HAMAP MF_00976 http://hamap.expasy.org/unirule/MF_00976 HOGENOM HOG000280809 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000280809&db=HOGENOM6 InParanoid P69411 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P69411 IntAct P69411 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69411* InterPro IPR030852 http://www.ebi.ac.uk/interpro/entry/IPR030852 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW0192 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0192 KEGG_Gene eco:b0196 http://www.genome.jp/dbget-bin/www_bget?eco:b0196 KEGG_Orthology KO:K06080 http://www.genome.jp/dbget-bin/www_bget?KO:K06080 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA FRDMGEV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FRDMGEV PDB 2L8Y http://www.ebi.ac.uk/pdbe-srv/view/entry/2L8Y PDB 2Y1B http://www.ebi.ac.uk/pdbe-srv/view/entry/2Y1B PDBsum 2L8Y http://www.ebi.ac.uk/pdbsum/2L8Y PDBsum 2Y1B http://www.ebi.ac.uk/pdbsum/2Y1B PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:RCSF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RCSF_ECOLI PSORT-B swissprot:RCSF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RCSF_ECOLI PSORT2 swissprot:RCSF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RCSF_ECOLI Pfam PF16358 http://pfam.xfam.org/family/PF16358 Phobius swissprot:RCSF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RCSF_ECOLI ProteinModelPortal P69411 http://www.proteinmodelportal.org/query/uniprot/P69411 PubMed 13129944 http://www.ncbi.nlm.nih.gov/pubmed/13129944 PubMed 1459951 http://www.ncbi.nlm.nih.gov/pubmed/1459951 PubMed 14651646 http://www.ncbi.nlm.nih.gov/pubmed/14651646 PubMed 16166540 http://www.ncbi.nlm.nih.gov/pubmed/16166540 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16740933 http://www.ncbi.nlm.nih.gov/pubmed/16740933 PubMed 21454485 http://www.ncbi.nlm.nih.gov/pubmed/21454485 PubMed 21471196 http://www.ncbi.nlm.nih.gov/pubmed/21471196 PubMed 23813676 http://www.ncbi.nlm.nih.gov/pubmed/23813676 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414738 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414738 RefSeq WP_001202329 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001202329 SMR P69411 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69411 STRING 511145.b0196 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0196&targetmode=cogs UniProtKB RCSF_ECOLI http://www.uniprot.org/uniprot/RCSF_ECOLI UniProtKB-AC P69411 http://www.uniprot.org/uniprot/P69411 charge swissprot:RCSF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RCSF_ECOLI eggNOG ENOG4108R8X http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108R8X eggNOG ENOG4111FP8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111FP8 epestfind swissprot:RCSF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RCSF_ECOLI garnier swissprot:RCSF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RCSF_ECOLI helixturnhelix swissprot:RCSF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RCSF_ECOLI hmoment swissprot:RCSF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RCSF_ECOLI iep swissprot:RCSF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RCSF_ECOLI inforesidue swissprot:RCSF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RCSF_ECOLI octanol swissprot:RCSF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RCSF_ECOLI pepcoil swissprot:RCSF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RCSF_ECOLI pepdigest swissprot:RCSF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RCSF_ECOLI pepinfo swissprot:RCSF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RCSF_ECOLI pepnet swissprot:RCSF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RCSF_ECOLI pepstats swissprot:RCSF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RCSF_ECOLI pepwheel swissprot:RCSF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RCSF_ECOLI pepwindow swissprot:RCSF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RCSF_ECOLI sigcleave swissprot:RCSF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RCSF_ECOLI ## Database ID URL or Descriptions # BioGrid 4261026 136 # CDD cd00555 Maf # EcoGene EG11438 yceF # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0047429 nucleoside-triphosphate diphosphatase activity; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # Gene3D 3.90.950.10 -; 1. # HAMAP MF_00528 Maf # InterPro IPR003697 Maf # InterPro IPR029001 ITPase-like_fam # Organism YCEF_ECOLI Escherichia coli (strain K12) # PATRIC 32117415 VBIEscCol129921_1130 # PDB 4JHC X-ray; 1.85 A; A/B=1-194 # PIR D64852 D64852 # PIRSF PIRSF006305 Maf # Pfam PF02545 Maf # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCEF_ECOLI Maf-like protein YceF # RefSeq NP_415605 NC_000913.3 # RefSeq WP_001125202 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA23829.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the maf family. {ECO 0000305}. # SUBCELLULAR LOCATION YCEF_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF52972 SSF52972 # TIGRFAMs TIGR00172 maf # eggNOG COG0424 LUCA # eggNOG ENOG4108UHJ Bacteria BLAST swissprot:YCEF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCEF_ECOLI BioCyc ECOL316407:JW5155-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5155-MONOMER BioCyc EcoCyc:EG11438-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11438-MONOMER BioCyc MetaCyc:EG11438-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11438-MONOMER DIP DIP-48156N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48156N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M96791 http://www.ebi.ac.uk/ena/data/view/M96791 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1408 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1408 EcoGene EG11438 http://www.ecogene.org/geneInfo.php?eg_id=EG11438 EnsemblBacteria AAC74171 http://www.ensemblgenomes.org/id/AAC74171 EnsemblBacteria AAC74171 http://www.ensemblgenomes.org/id/AAC74171 EnsemblBacteria BAA35895 http://www.ensemblgenomes.org/id/BAA35895 EnsemblBacteria BAA35895 http://www.ensemblgenomes.org/id/BAA35895 EnsemblBacteria BAA35895 http://www.ensemblgenomes.org/id/BAA35895 EnsemblBacteria b1087 http://www.ensemblgenomes.org/id/b1087 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0047429 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047429 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 Gene3D 3.90.950.10 http://www.cathdb.info/version/latest/superfamily/3.90.950.10 GeneID 945631 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945631 HAMAP MF_00528 http://hamap.expasy.org/unirule/MF_00528 HOGENOM HOG000241744 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000241744&db=HOGENOM6 InParanoid P0A729 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A729 InterPro IPR003697 http://www.ebi.ac.uk/interpro/entry/IPR003697 InterPro IPR029001 http://www.ebi.ac.uk/interpro/entry/IPR029001 KEGG_Gene ecj:JW5155 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5155 KEGG_Gene eco:b1087 http://www.genome.jp/dbget-bin/www_bget?eco:b1087 OMA CAGSFKA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CAGSFKA PDB 4JHC http://www.ebi.ac.uk/pdbe-srv/view/entry/4JHC PDBsum 4JHC http://www.ebi.ac.uk/pdbsum/4JHC PSORT swissprot:YCEF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCEF_ECOLI PSORT-B swissprot:YCEF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCEF_ECOLI PSORT2 swissprot:YCEF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCEF_ECOLI Pfam PF02545 http://pfam.xfam.org/family/PF02545 Phobius swissprot:YCEF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCEF_ECOLI PhylomeDB P0A729 http://phylomedb.org/?seqid=P0A729 ProteinModelPortal P0A729 http://www.proteinmodelportal.org/query/uniprot/P0A729 PubMed 1447160 http://www.ncbi.nlm.nih.gov/pubmed/1447160 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415605 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415605 RefSeq WP_001125202 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001125202 SMR P0A729 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A729 STRING 511145.b1087 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1087&targetmode=cogs SUPFAM SSF52972 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52972 TIGRFAMs TIGR00172 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00172 UniProtKB YCEF_ECOLI http://www.uniprot.org/uniprot/YCEF_ECOLI UniProtKB-AC P0A729 http://www.uniprot.org/uniprot/P0A729 charge swissprot:YCEF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCEF_ECOLI eggNOG COG0424 http://eggnogapi.embl.de/nog_data/html/tree/COG0424 eggNOG ENOG4108UHJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UHJ epestfind swissprot:YCEF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCEF_ECOLI garnier swissprot:YCEF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCEF_ECOLI helixturnhelix swissprot:YCEF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCEF_ECOLI hmoment swissprot:YCEF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCEF_ECOLI iep swissprot:YCEF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCEF_ECOLI inforesidue swissprot:YCEF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCEF_ECOLI octanol swissprot:YCEF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCEF_ECOLI pepcoil swissprot:YCEF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCEF_ECOLI pepdigest swissprot:YCEF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCEF_ECOLI pepinfo swissprot:YCEF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCEF_ECOLI pepnet swissprot:YCEF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCEF_ECOLI pepstats swissprot:YCEF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCEF_ECOLI pepwheel swissprot:YCEF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCEF_ECOLI pepwindow swissprot:YCEF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCEF_ECOLI sigcleave swissprot:YCEF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCEF_ECOLI ## Database ID URL or Descriptions # AltName SUBI_ECOLI Sulfate starvation-induced protein 2 # BioGrid 4261220 7 # CDD cd01005 PBP2_CysP # EcoGene EG10929 sbp # FUNCTION SUBI_ECOLI This protein specifically binds sulfate and is involved in its transmembrane transport. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0008271 secondary active sulfate transmembrane transporter activity; IEA:InterPro. # GO_function GO:0015419 ATPase-coupled sulfate transmembrane transporter activity; IEA:InterPro. # GO_function GO:0043199 sulfate binding; IDA:EcoCyc. # GO_process GO:0006790 sulfur compound metabolic process; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006790 sulfur compound metabolic process # INDUCTION SUBI_ECOLI Repressed by sulfate or cysteine. # IntAct P0AG78 11 # InterPro IPR000957 Sulphate/thiosulphate-bd_CS # InterPro IPR005669 Thiosulph/SO4-bd # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00185 Sulfate transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism SUBI_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30368 PTHR30368 # PATRIC 32123347 VBIEscCol129921_4034 # PIR S40860 BYEC # PROSITE PS00401 PROK_SULFATE_BIND_1 # PROSITE PS00757 PROK_SULFATE_BIND_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SUBI_ECOLI Sulfate-binding protein # RefSeq NP_418352 NC_000913.3 # RefSeq WP_001045689 NZ_LN832404.1 # SIMILARITY Belongs to the prokaryotic sulfate-binding protein family. {ECO 0000305}. # SUBCELLULAR LOCATION SUBI_ECOLI Periplasm. # TCDB 3.A.1.6 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR00971 3a0106s03 # eggNOG COG1613 LUCA # eggNOG ENOG4105DE7 Bacteria BLAST swissprot:SUBI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SUBI_ECOLI BioCyc ECOL316407:JW3888-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3888-MONOMER BioCyc EcoCyc:SBP-MONOMER http://biocyc.org/getid?id=EcoCyc:SBP-MONOMER BioCyc MetaCyc:SBP-MONOMER http://biocyc.org/getid?id=MetaCyc:SBP-MONOMER COG COG1613 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1613 DIP DIP-35843N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35843N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1111/j.1432-1033.1985.tb08934.x http://dx.doi.org/10.1111/j.1432-1033.1985.tb08934.x DOI 10.1111/j.1432-1033.1996.0773u.x http://dx.doi.org/10.1111/j.1432-1033.1996.0773u.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X02519 http://www.ebi.ac.uk/ena/data/view/X02519 EchoBASE EB0922 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0922 EcoGene EG10929 http://www.ecogene.org/geneInfo.php?eg_id=EG10929 EnsemblBacteria AAC76899 http://www.ensemblgenomes.org/id/AAC76899 EnsemblBacteria AAC76899 http://www.ensemblgenomes.org/id/AAC76899 EnsemblBacteria BAE77393 http://www.ensemblgenomes.org/id/BAE77393 EnsemblBacteria BAE77393 http://www.ensemblgenomes.org/id/BAE77393 EnsemblBacteria BAE77393 http://www.ensemblgenomes.org/id/BAE77393 EnsemblBacteria b3917 http://www.ensemblgenomes.org/id/b3917 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0008271 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008271 GO_function GO:0015419 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015419 GO_function GO:0043199 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043199 GO_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GeneID 948411 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948411 HOGENOM HOG000260057 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260057&db=HOGENOM6 InParanoid P0AG78 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AG78 IntAct P0AG78 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AG78* InterPro IPR000957 http://www.ebi.ac.uk/interpro/entry/IPR000957 InterPro IPR005669 http://www.ebi.ac.uk/interpro/entry/IPR005669 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3888 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3888 KEGG_Gene eco:b3917 http://www.genome.jp/dbget-bin/www_bget?eco:b3917 KEGG_Orthology KO:K02048 http://www.genome.jp/dbget-bin/www_bget?KO:K02048 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA TIDKDFG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TIDKDFG PANTHER PTHR30368 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30368 PROSITE PS00401 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00401 PROSITE PS00757 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00757 PSORT swissprot:SUBI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SUBI_ECOLI PSORT-B swissprot:SUBI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SUBI_ECOLI PSORT2 swissprot:SUBI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SUBI_ECOLI Phobius swissprot:SUBI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SUBI_ECOLI PhylomeDB P0AG78 http://phylomedb.org/?seqid=P0AG78 ProteinModelPortal P0AG78 http://www.proteinmodelportal.org/query/uniprot/P0AG78 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2002055 http://www.ncbi.nlm.nih.gov/pubmed/2002055 PubMed 3158524 http://www.ncbi.nlm.nih.gov/pubmed/3158524 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 8774726 http://www.ncbi.nlm.nih.gov/pubmed/8774726 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_418352 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418352 RefSeq WP_001045689 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001045689 SMR P0AG78 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AG78 STRING 511145.b3917 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3917&targetmode=cogs STRING COG1613 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1613&targetmode=cogs SWISS-2DPAGE P0AG78 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AG78 TCDB 3.A.1.6 http://www.tcdb.org/search/result.php?tc=3.A.1.6 TIGRFAMs TIGR00971 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00971 UniProtKB SUBI_ECOLI http://www.uniprot.org/uniprot/SUBI_ECOLI UniProtKB-AC P0AG78 http://www.uniprot.org/uniprot/P0AG78 charge swissprot:SUBI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SUBI_ECOLI eggNOG COG1613 http://eggnogapi.embl.de/nog_data/html/tree/COG1613 eggNOG ENOG4105DE7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DE7 epestfind swissprot:SUBI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SUBI_ECOLI garnier swissprot:SUBI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SUBI_ECOLI helixturnhelix swissprot:SUBI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SUBI_ECOLI hmoment swissprot:SUBI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SUBI_ECOLI iep swissprot:SUBI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SUBI_ECOLI inforesidue swissprot:SUBI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SUBI_ECOLI octanol swissprot:SUBI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SUBI_ECOLI pepcoil swissprot:SUBI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SUBI_ECOLI pepdigest swissprot:SUBI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SUBI_ECOLI pepinfo swissprot:SUBI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SUBI_ECOLI pepnet swissprot:SUBI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SUBI_ECOLI pepstats swissprot:SUBI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SUBI_ECOLI pepwheel swissprot:SUBI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SUBI_ECOLI pepwindow swissprot:SUBI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SUBI_ECOLI sigcleave swissprot:SUBI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SUBI_ECOLI ## Database ID URL or Descriptions # BioGrid 4261206 122 # EcoGene EG14158 ybfP # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GOslim_component GO:0005886 plasma membrane # Organism YBFP_ECOLI Escherichia coli (strain K12) # PATRIC 32116573 VBIEscCol129921_0719 # PIR H64803 H64803 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBFP_ECOLI Uncharacterized lipoprotein YbfP # RefSeq NP_415215 NC_000913.3 # RefSeq WP_000856353 NZ_LN832404.1 # SUBCELLULAR LOCATION YBFP_ECOLI Cell membrane {ECO 0000305}; Lipid-anchor {ECO 0000305}. BLAST swissprot:YBFP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBFP_ECOLI BioCyc ECOL316407:JW0676-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0676-MONOMER BioCyc EcoCyc:G6374-MONOMER http://biocyc.org/getid?id=EcoCyc:G6374-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3910 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3910 EcoGene EG14158 http://www.ecogene.org/geneInfo.php?eg_id=EG14158 EnsemblBacteria AAC73783 http://www.ensemblgenomes.org/id/AAC73783 EnsemblBacteria AAC73783 http://www.ensemblgenomes.org/id/AAC73783 EnsemblBacteria BAE76358 http://www.ensemblgenomes.org/id/BAE76358 EnsemblBacteria BAE76358 http://www.ensemblgenomes.org/id/BAE76358 EnsemblBacteria BAE76358 http://www.ensemblgenomes.org/id/BAE76358 EnsemblBacteria b0689 http://www.ensemblgenomes.org/id/b0689 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 945274 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945274 HOGENOM HOG000009717 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009717&db=HOGENOM6 KEGG_Gene ecj:JW0676 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0676 KEGG_Gene eco:b0689 http://www.genome.jp/dbget-bin/www_bget?eco:b0689 OMA NIAPSRC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NIAPSRC PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YBFP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBFP_ECOLI PSORT-B swissprot:YBFP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBFP_ECOLI PSORT2 swissprot:YBFP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBFP_ECOLI Phobius swissprot:YBFP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBFP_ECOLI ProteinModelPortal P75737 http://www.proteinmodelportal.org/query/uniprot/P75737 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415215 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415215 RefSeq WP_000856353 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000856353 STRING 511145.b0689 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0689&targetmode=cogs UniProtKB YBFP_ECOLI http://www.uniprot.org/uniprot/YBFP_ECOLI UniProtKB-AC P75737 http://www.uniprot.org/uniprot/P75737 charge swissprot:YBFP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBFP_ECOLI epestfind swissprot:YBFP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBFP_ECOLI garnier swissprot:YBFP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBFP_ECOLI helixturnhelix swissprot:YBFP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBFP_ECOLI hmoment swissprot:YBFP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBFP_ECOLI iep swissprot:YBFP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBFP_ECOLI inforesidue swissprot:YBFP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBFP_ECOLI octanol swissprot:YBFP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBFP_ECOLI pepcoil swissprot:YBFP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBFP_ECOLI pepdigest swissprot:YBFP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBFP_ECOLI pepinfo swissprot:YBFP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBFP_ECOLI pepnet swissprot:YBFP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBFP_ECOLI pepstats swissprot:YBFP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBFP_ECOLI pepwheel swissprot:YBFP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBFP_ECOLI pepwindow swissprot:YBFP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBFP_ECOLI sigcleave swissprot:YBFP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBFP_ECOLI ## Database ID URL or Descriptions # BioGrid 4259124 494 # EcoGene EG13926 mdtI # FUNCTION MDTI_ECOLI Catalyzes the excretion of spermidine. Can also confer resistance to deoxycholate and SDS. {ECO 0000269|PubMed 11566977, ECO 0000269|PubMed 18039771}. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoliWiki. # GO_function GO:0015606 spermidine transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:1903711 spermidine transmembrane transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0055085 transmembrane transport # HAMAP MF_01597 MdtI # INDUCTION Induced by spermidine. {ECO:0000269|PubMed 18039771}. # InterPro IPR000390 Small_multidrug_res # InterPro IPR023737 Spermidine_export_MdtI # KEGG_Brite ko02000 Transporters # Organism MDTI_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30561:SF6 PTHR30561:SF6 # PATRIC 32118500 VBIEscCol129921_1670 # PIR A64916 A64916 # Pfam PF00893 Multi_Drug_Res # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MDTI_ECOLI Spermidine export protein MdtI # RefSeq NP_416116 NC_000913.3 # RefSeq WP_000046661 NZ_LN832404.1 # SIMILARITY Belongs to the small multidrug resistance (SMR) protein family. MdtI subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION MDTI_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT Forms a complex with MdtJ. {ECO:0000305|PubMed 18039771}. # TCDB 2.A.7.1 the drug/metabolite transporter (dmt) superfamily # eggNOG COG2076 LUCA # eggNOG ENOG4108ZBZ Bacteria BLAST swissprot:MDTI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MDTI_ECOLI BioCyc ECOL316407:JW1591-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1591-MONOMER BioCyc EcoCyc:B1599-MONOMER http://biocyc.org/getid?id=EcoCyc:B1599-MONOMER BioCyc MetaCyc:B1599-MONOMER http://biocyc.org/getid?id=MetaCyc:B1599-MONOMER COG COG2076 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2076 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.052018199 http://dx.doi.org/10.1073/pnas.052018199 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01505-07 http://dx.doi.org/10.1128/JB.01505-07 DOI 10.1128/JB.183.20.5803-5812.2001 http://dx.doi.org/10.1128/JB.183.20.5803-5812.2001 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3685 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3685 EcoGene EG13926 http://www.ecogene.org/geneInfo.php?eg_id=EG13926 EnsemblBacteria AAC74671 http://www.ensemblgenomes.org/id/AAC74671 EnsemblBacteria AAC74671 http://www.ensemblgenomes.org/id/AAC74671 EnsemblBacteria BAA15333 http://www.ensemblgenomes.org/id/BAA15333 EnsemblBacteria BAA15333 http://www.ensemblgenomes.org/id/BAA15333 EnsemblBacteria BAA15333 http://www.ensemblgenomes.org/id/BAA15333 EnsemblBacteria b1599 http://www.ensemblgenomes.org/id/b1599 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015606 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015606 GO_process GO:1903711 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903711 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 947333 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947333 HAMAP MF_01597 http://hamap.expasy.org/unirule/MF_01597 HOGENOM HOG000268006 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000268006&db=HOGENOM6 InParanoid P69210 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P69210 IntAct P69210 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69210* InterPro IPR000390 http://www.ebi.ac.uk/interpro/entry/IPR000390 InterPro IPR023737 http://www.ebi.ac.uk/interpro/entry/IPR023737 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1591 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1591 KEGG_Gene eco:b1599 http://www.genome.jp/dbget-bin/www_bget?eco:b1599 KEGG_Orthology KO:K11742 http://www.genome.jp/dbget-bin/www_bget?KO:K11742 OMA FRRKFYG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FRRKFYG PANTHER PTHR30561:SF6 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30561:SF6 PSORT swissprot:MDTI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MDTI_ECOLI PSORT-B swissprot:MDTI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MDTI_ECOLI PSORT2 swissprot:MDTI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MDTI_ECOLI Pfam PF00893 http://pfam.xfam.org/family/PF00893 Phobius swissprot:MDTI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MDTI_ECOLI PhylomeDB P69210 http://phylomedb.org/?seqid=P69210 ProteinModelPortal P69210 http://www.proteinmodelportal.org/query/uniprot/P69210 PubMed 11566977 http://www.ncbi.nlm.nih.gov/pubmed/11566977 PubMed 11867724 http://www.ncbi.nlm.nih.gov/pubmed/11867724 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18039771 http://www.ncbi.nlm.nih.gov/pubmed/18039771 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416116 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416116 RefSeq WP_000046661 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000046661 SMR P69210 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69210 STRING 511145.b1599 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1599&targetmode=cogs STRING COG2076 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2076&targetmode=cogs TCDB 2.A.7.1 http://www.tcdb.org/search/result.php?tc=2.A.7.1 UniProtKB MDTI_ECOLI http://www.uniprot.org/uniprot/MDTI_ECOLI UniProtKB-AC P69210 http://www.uniprot.org/uniprot/P69210 charge swissprot:MDTI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MDTI_ECOLI eggNOG COG2076 http://eggnogapi.embl.de/nog_data/html/tree/COG2076 eggNOG ENOG4108ZBZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZBZ epestfind swissprot:MDTI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MDTI_ECOLI garnier swissprot:MDTI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MDTI_ECOLI helixturnhelix swissprot:MDTI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MDTI_ECOLI hmoment swissprot:MDTI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MDTI_ECOLI iep swissprot:MDTI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MDTI_ECOLI inforesidue swissprot:MDTI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MDTI_ECOLI octanol swissprot:MDTI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MDTI_ECOLI pepcoil swissprot:MDTI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MDTI_ECOLI pepdigest swissprot:MDTI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MDTI_ECOLI pepinfo swissprot:MDTI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MDTI_ECOLI pepnet swissprot:MDTI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MDTI_ECOLI pepstats swissprot:MDTI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MDTI_ECOLI pepwheel swissprot:MDTI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MDTI_ECOLI pepwindow swissprot:MDTI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MDTI_ECOLI sigcleave swissprot:MDTI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MDTI_ECOLI ## Database ID URL or Descriptions # BioGrid 4260636 134 # EcoGene EG12032 psuT # FUNCTION PSUT_ECOLI Could be involved in pseudouridine transport. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0005337 nucleoside transmembrane transporter activity; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # IntAct P33024 2 # InterPro IPR002668 CNT_N_dom # InterPro IPR008276 C_nuclsd_transpt # InterPro IPR011657 CNT_C_dom # InterPro IPR018270 C_nuclsd_transpt_met_bac # KEGG_Brite ko02000 Transporters # Organism PSUT_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10590 PTHR10590 # PATRIC 32119677 VBIEscCol129921_2249 # PIR C64985 C64985 # Pfam PF01773 Nucleos_tra2_N # Pfam PF07662 Nucleos_tra2_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PSUT_ECOLI Putative pseudouridine transporter # RefSeq NP_416669 NC_000913.3 # RefSeq WP_000353878 NZ_LN832404.1 # SIMILARITY Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family. {ECO 0000305}. # SUBCELLULAR LOCATION PSUT_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.41.2 the concentrative nucleoside transporter (cnt) family # TIGRFAMs TIGR00804 nupC # eggNOG COG1972 LUCA # eggNOG ENOG4105D9N Bacteria BLAST swissprot:PSUT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PSUT_ECOLI BioCyc ECOL316407:JW2151-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2151-MONOMER BioCyc EcoCyc:YEIM-MONOMER http://biocyc.org/getid?id=EcoCyc:YEIM-MONOMER COG COG1972 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1972 DIP DIP-11925N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11925N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1967 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1967 EcoGene EG12032 http://www.ecogene.org/geneInfo.php?eg_id=EG12032 EnsemblBacteria AAC75225 http://www.ensemblgenomes.org/id/AAC75225 EnsemblBacteria AAC75225 http://www.ensemblgenomes.org/id/AAC75225 EnsemblBacteria BAE76641 http://www.ensemblgenomes.org/id/BAE76641 EnsemblBacteria BAE76641 http://www.ensemblgenomes.org/id/BAE76641 EnsemblBacteria BAE76641 http://www.ensemblgenomes.org/id/BAE76641 EnsemblBacteria b2164 http://www.ensemblgenomes.org/id/b2164 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0005337 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005337 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GeneID 946671 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946671 HOGENOM HOG000267656 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267656&db=HOGENOM6 InParanoid P33024 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33024 IntAct P33024 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33024* InterPro IPR002668 http://www.ebi.ac.uk/interpro/entry/IPR002668 InterPro IPR008276 http://www.ebi.ac.uk/interpro/entry/IPR008276 InterPro IPR011657 http://www.ebi.ac.uk/interpro/entry/IPR011657 InterPro IPR018270 http://www.ebi.ac.uk/interpro/entry/IPR018270 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2151 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2151 KEGG_Gene eco:b2164 http://www.genome.jp/dbget-bin/www_bget?eco:b2164 KEGG_Orthology KO:K16324 http://www.genome.jp/dbget-bin/www_bget?KO:K16324 MINT MINT-1248538 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1248538 OMA FCKTHAS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FCKTHAS PANTHER PTHR10590 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10590 PSORT swissprot:PSUT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PSUT_ECOLI PSORT-B swissprot:PSUT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PSUT_ECOLI PSORT2 swissprot:PSUT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PSUT_ECOLI Pfam PF01773 http://pfam.xfam.org/family/PF01773 Pfam PF07662 http://pfam.xfam.org/family/PF07662 Phobius swissprot:PSUT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PSUT_ECOLI PhylomeDB P33024 http://phylomedb.org/?seqid=P33024 ProteinModelPortal P33024 http://www.proteinmodelportal.org/query/uniprot/P33024 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416669 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416669 RefSeq WP_000353878 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000353878 SMR P33024 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33024 STRING 511145.b2164 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2164&targetmode=cogs STRING COG1972 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1972&targetmode=cogs TCDB 2.A.41.2 http://www.tcdb.org/search/result.php?tc=2.A.41.2 TIGRFAMs TIGR00804 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00804 UniProtKB PSUT_ECOLI http://www.uniprot.org/uniprot/PSUT_ECOLI UniProtKB-AC P33024 http://www.uniprot.org/uniprot/P33024 charge swissprot:PSUT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PSUT_ECOLI eggNOG COG1972 http://eggnogapi.embl.de/nog_data/html/tree/COG1972 eggNOG ENOG4105D9N http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D9N epestfind swissprot:PSUT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PSUT_ECOLI garnier swissprot:PSUT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PSUT_ECOLI helixturnhelix swissprot:PSUT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PSUT_ECOLI hmoment swissprot:PSUT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PSUT_ECOLI iep swissprot:PSUT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PSUT_ECOLI inforesidue swissprot:PSUT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PSUT_ECOLI octanol swissprot:PSUT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PSUT_ECOLI pepcoil swissprot:PSUT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PSUT_ECOLI pepdigest swissprot:PSUT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PSUT_ECOLI pepinfo swissprot:PSUT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PSUT_ECOLI pepnet swissprot:PSUT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PSUT_ECOLI pepstats swissprot:PSUT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PSUT_ECOLI pepwheel swissprot:PSUT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PSUT_ECOLI pepwindow swissprot:PSUT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PSUT_ECOLI sigcleave swissprot:PSUT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PSUT_ECOLI ## Database ID URL or Descriptions # BioGrid 4259664 7 # CDD cd09971 SdiA-regulated # EcoGene EG12572 yjiK # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # Gene3D 2.120.10.30 -; 1. # InterPro IPR009722 SdiA-regulated # InterPro IPR011042 6-blade_b-propeller_TolB-like # Organism YJIK_ECOLI Escherichia coli (strain K12) # PATRIC 32124270 VBIEscCol129921_4478 # PIR S56558 S56558 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF06977 SdiA-regulated # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJIK_ECOLI Uncharacterized protein YjiK # RefSeq NP_418753 NC_000913.3 # RefSeq WP_001350572 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97229.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAE78326.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the YjiK family. {ECO 0000305}. # SUBCELLULAR LOCATION YJIK_ECOLI Cell membrane {ECO 0000255|PROSITE- ProRule PRU00303}; Single-pass membrane protein {ECO 0000305}. # eggNOG COG3204 LUCA # eggNOG ENOG4108ZK4 Bacteria BLAST swissprot:YJIK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJIK_ECOLI BioCyc ECOL316407:JW5869-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5869-MONOMER BioCyc EcoCyc:G7930-MONOMER http://biocyc.org/getid?id=EcoCyc:G7930-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2460 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2460 EcoGene EG12572 http://www.ecogene.org/geneInfo.php?eg_id=EG12572 EnsemblBacteria AAC77289 http://www.ensemblgenomes.org/id/AAC77289 EnsemblBacteria AAC77289 http://www.ensemblgenomes.org/id/AAC77289 EnsemblBacteria BAE78326 http://www.ensemblgenomes.org/id/BAE78326 EnsemblBacteria BAE78326 http://www.ensemblgenomes.org/id/BAE78326 EnsemblBacteria BAE78326 http://www.ensemblgenomes.org/id/BAE78326 EnsemblBacteria b4333 http://www.ensemblgenomes.org/id/b4333 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 Gene3D 2.120.10.30 http://www.cathdb.info/version/latest/superfamily/2.120.10.30 GeneID 948957 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948957 HOGENOM HOG000247221 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000247221&db=HOGENOM6 InParanoid P39382 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39382 InterPro IPR009722 http://www.ebi.ac.uk/interpro/entry/IPR009722 InterPro IPR011042 http://www.ebi.ac.uk/interpro/entry/IPR011042 KEGG_Gene ecj:JW5869 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5869 KEGG_Gene eco:b4333 http://www.genome.jp/dbget-bin/www_bget?eco:b4333 OMA AKERDPM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AKERDPM PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YJIK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJIK_ECOLI PSORT-B swissprot:YJIK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJIK_ECOLI PSORT2 swissprot:YJIK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJIK_ECOLI Pfam PF06977 http://pfam.xfam.org/family/PF06977 Phobius swissprot:YJIK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJIK_ECOLI PhylomeDB P39382 http://phylomedb.org/?seqid=P39382 ProteinModelPortal P39382 http://www.proteinmodelportal.org/query/uniprot/P39382 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418753 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418753 RefSeq WP_001350572 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001350572 SMR P39382 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39382 STRING 511145.b4333 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4333&targetmode=cogs UniProtKB YJIK_ECOLI http://www.uniprot.org/uniprot/YJIK_ECOLI UniProtKB-AC P39382 http://www.uniprot.org/uniprot/P39382 charge swissprot:YJIK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJIK_ECOLI eggNOG COG3204 http://eggnogapi.embl.de/nog_data/html/tree/COG3204 eggNOG ENOG4108ZK4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZK4 epestfind swissprot:YJIK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJIK_ECOLI garnier swissprot:YJIK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJIK_ECOLI helixturnhelix swissprot:YJIK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJIK_ECOLI hmoment swissprot:YJIK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJIK_ECOLI iep swissprot:YJIK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJIK_ECOLI inforesidue swissprot:YJIK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJIK_ECOLI octanol swissprot:YJIK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJIK_ECOLI pepcoil swissprot:YJIK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJIK_ECOLI pepdigest swissprot:YJIK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJIK_ECOLI pepinfo swissprot:YJIK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJIK_ECOLI pepnet swissprot:YJIK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJIK_ECOLI pepstats swissprot:YJIK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJIK_ECOLI pepwheel swissprot:YJIK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJIK_ECOLI pepwindow swissprot:YJIK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJIK_ECOLI sigcleave swissprot:YJIK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJIK_ECOLI ## Database ID URL or Descriptions # FUNCTION TRAN_ECOLI Essential for F plasmid conjugative transfer. May interact with the recipient cell surface to stabilize mating pairs initiated by F-pili. May interact with TraG. # GO_component GO:0009279 cell outer membrane; IEA:UniProtKB-SubCell. # GO_process GO:0000746 conjugation; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0008150 biological_process # InterPro IPR014121 TraN_Ftype # Organism TRAN_ECOLI Escherichia coli (strain K12) # PIR S23991 S23991 # Pfam PF06986 TraN # RecName TRAN_ECOLI Protein TraN # RefSeq NP_061468 NC_002483.1 # RefSeq WP_000821835 NZ_CP014273.1 # SUBCELLULAR LOCATION TRAN_ECOLI Cell outer membrane {ECO 0000269|PubMed 1593622}. # TIGRFAMs TIGR02750 TraN_Ftype BLAST swissprot:TRAN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRAN_ECOLI DOI 10.1016/0022-2836(92)90923-8 http://dx.doi.org/10.1016/0022-2836(92)90923-8 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL M60427 http://www.ebi.ac.uk/ena/data/view/M60427 EMBL U01159 http://www.ebi.ac.uk/ena/data/view/U01159 EMBL X61575 http://www.ebi.ac.uk/ena/data/view/X61575 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_process GO:0000746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000746 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 1263575 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263575 InterPro IPR014121 http://www.ebi.ac.uk/interpro/entry/IPR014121 OMA CERDLQV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CERDLQV PSORT swissprot:TRAN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRAN_ECOLI PSORT-B swissprot:TRAN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRAN_ECOLI PSORT2 swissprot:TRAN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRAN_ECOLI Pfam PF06986 http://pfam.xfam.org/family/PF06986 Phobius swissprot:TRAN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRAN_ECOLI ProteinModelPortal P24082 http://www.proteinmodelportal.org/query/uniprot/P24082 PubMed 1593622 http://www.ncbi.nlm.nih.gov/pubmed/1593622 PubMed 2050638 http://www.ncbi.nlm.nih.gov/pubmed/2050638 PubMed 7915817 http://www.ncbi.nlm.nih.gov/pubmed/7915817 RefSeq NP_061468 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061468 RefSeq WP_000821835 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000821835 TIGRFAMs TIGR02750 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02750 UniProtKB TRAN_ECOLI http://www.uniprot.org/uniprot/TRAN_ECOLI UniProtKB-AC P24082 http://www.uniprot.org/uniprot/P24082 charge swissprot:TRAN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRAN_ECOLI epestfind swissprot:TRAN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRAN_ECOLI garnier swissprot:TRAN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRAN_ECOLI helixturnhelix swissprot:TRAN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRAN_ECOLI hmoment swissprot:TRAN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRAN_ECOLI iep swissprot:TRAN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRAN_ECOLI inforesidue swissprot:TRAN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRAN_ECOLI octanol swissprot:TRAN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRAN_ECOLI pepcoil swissprot:TRAN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRAN_ECOLI pepdigest swissprot:TRAN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRAN_ECOLI pepinfo swissprot:TRAN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRAN_ECOLI pepnet swissprot:TRAN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRAN_ECOLI pepstats swissprot:TRAN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRAN_ECOLI pepwheel swissprot:TRAN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRAN_ECOLI pepwindow swissprot:TRAN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRAN_ECOLI sigcleave swissprot:TRAN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRAN_ECOLI ## Database ID URL or Descriptions # AltName PLSC_ECOLI Lysophosphatidic acid acyltransferase # AltName PLSC_ECOLI Phosphatidic acid synthase # BioGrid 4261779 227 # CATALYTIC ACTIVITY PLSC_ECOLI Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate. # CATALYTIC ACTIVITY PLSC_ECOLI Acyl-[acyl-carrier-protein] + 1-acyl-sn- glycerol 3-phosphate = [acyl-carrier-protein] + 1,2-diacyl-sn- glycerol 3-phosphate. # DOMAIN PLSC_ECOLI The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. {ECO 0000250}. # EcoGene EG11377 plsC # FUNCTION PLSC_ECOLI Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the 2 position. This enzyme can utilize either acyl-CoA or acyl-ACP as the fatty acyl donor. {ECO 0000269|PubMed 2211622}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_function GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity; IMP:EcoCyc. # GO_function GO:0004147 dihydrolipoamide branched chain acyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0008951 palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016406 carnitine O-acyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016412 serine O-acyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016413 O-acetyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016414 O-octanoyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016416 O-palmitoyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016418 S-acetyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016419 S-malonyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016454 C-palmitoyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016749 N-succinyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016750 O-succinyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016751 S-succinyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0016753 O-sinapoyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0018030 peptidyl-lysine N6-myristoyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0018031 peptidyl-lysine N6-palmitoyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0018711 benzoyl acetate-CoA thiolase activity; IEA:UniProtKB-EC. # GO_function GO:0018712 3-hydroxybutyryl-CoA thiolase activity; IEA:UniProtKB-EC. # GO_function GO:0018713 3-ketopimelyl-CoA thiolase activity; IEA:UniProtKB-EC. # GO_function GO:0019186 acyl-CoA N-acyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0019705 protein-cysteine S-myristoyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0032216 glucosaminyl-phosphotidylinositol O-acyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0034737 ergosterol O-acyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0034738 lanosterol O-acyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0034848 naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity; IEA:UniProtKB-EC. # GO_function GO:0034851 2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity; IEA:UniProtKB-EC. # GO_function GO:0034915 2-methylhexanoyl-CoA C-acetyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0034919 butyryl-CoA 2-C-propionyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0034945 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0043741 L-2-aminoadipate N-acetyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0043806 keto acid formate lyase activity; IEA:UniProtKB-EC. # GO_function GO:0043849 Ras palmitoyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0046941 azetidine-2-carboxylic acid acetyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0052858 peptidyl-lysine acetyltransferase activity; IEA:UniProtKB-EC. # GO_function PLSC_ECOLI GO 0090595 acetyl-CoA L-lysine N6-acetyltransferase; IEA UniProtKB-EC. # GO_process GO:0016024 CDP-diacylglycerol biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0046474 glycerophospholipid biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # InterPro IPR002123 Plipid/glycerol_acylTrfase # InterPro IPR004552 AGP_acyltrans # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01004 Lipid biosynthesis proteins # KEGG_Pathway ko00561 Glycerolipid metabolism # KEGG_Pathway ko00564 Glycerophospholipid metabolism # Organism PLSC_ECOLI Escherichia coli (strain K12) # PATHWAY Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate step 2/3. # PATRIC 32121450 VBIEscCol129921_3112 # PIR S20460 S20460 # Pfam PF01553 Acyltransferase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PLSC_ECOLI 1-acyl-sn-glycerol-3-phosphate acyltransferase # RefSeq NP_417490 NC_000913.3 # RefSeq WP_000965722 NZ_LN832404.1 # SIMILARITY Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. {ECO 0000305}. # SMART SM00563 PlsC # SUBCELLULAR LOCATION PLSC_ECOLI Cell inner membrane {ECO 0000269|PubMed 1557036}; Peripheral membrane protein {ECO 0000269|PubMed 1557036}. # TIGRFAMs TIGR00530 AGP_acyltrn # UniPathway UPA00557 UER00613 # eggNOG COG0204 LUCA # eggNOG ENOG4107S7E Bacteria BLAST swissprot:PLSC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PLSC_ECOLI BioCyc ECOL316407:JW2986-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2986-MONOMER BioCyc EcoCyc:1-ACYLGLYCEROL-3-P-ACYLTRANSFER-MONOMER http://biocyc.org/getid?id=EcoCyc:1-ACYLGLYCEROL-3-P-ACYLTRANSFER-MONOMER BioCyc MetaCyc:1-ACYLGLYCEROL-3-P-ACYLTRANSFER-MONOMER http://biocyc.org/getid?id=MetaCyc:1-ACYLGLYCEROL-3-P-ACYLTRANSFER-MONOMER COG COG0204 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0204 DIP DIP-10516N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10516N DOI 10.1016/j.molcel.2006.06.030 http://dx.doi.org/10.1016/j.molcel.2006.06.030 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.51 http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.51 EC_number EC:2.3.1.n4 http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.n4 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M63491 http://www.ebi.ac.uk/ena/data/view/M63491 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 ENZYME 2.3.1.51 http://enzyme.expasy.org/EC/2.3.1.51 ENZYME 2.3.1.n4 http://enzyme.expasy.org/EC/2.3.1.n4 EchoBASE EB1351 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1351 EcoGene EG11377 http://www.ecogene.org/geneInfo.php?eg_id=EG11377 EnsemblBacteria AAC76054 http://www.ensemblgenomes.org/id/AAC76054 EnsemblBacteria AAC76054 http://www.ensemblgenomes.org/id/AAC76054 EnsemblBacteria BAE77074 http://www.ensemblgenomes.org/id/BAE77074 EnsemblBacteria BAE77074 http://www.ensemblgenomes.org/id/BAE77074 EnsemblBacteria BAE77074 http://www.ensemblgenomes.org/id/BAE77074 EnsemblBacteria b3018 http://www.ensemblgenomes.org/id/b3018 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0003841 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003841 GO_function GO:0004147 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004147 GO_function GO:0008951 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008951 GO_function GO:0016406 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016406 GO_function GO:0016412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016412 GO_function GO:0016413 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016413 GO_function GO:0016414 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016414 GO_function GO:0016416 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016416 GO_function GO:0016418 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016418 GO_function GO:0016419 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016419 GO_function GO:0016454 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016454 GO_function GO:0016749 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016749 GO_function GO:0016750 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016750 GO_function GO:0016751 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016751 GO_function GO:0016753 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016753 GO_function GO:0018030 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018030 GO_function GO:0018031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018031 GO_function GO:0018711 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018711 GO_function GO:0018712 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018712 GO_function GO:0018713 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018713 GO_function GO:0019186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019186 GO_function GO:0019705 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019705 GO_function GO:0032216 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032216 GO_function GO:0034737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034737 GO_function GO:0034738 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034738 GO_function GO:0034848 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034848 GO_function GO:0034851 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034851 GO_function GO:0034915 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034915 GO_function GO:0034919 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034919 GO_function GO:0034945 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034945 GO_function GO:0043741 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043741 GO_function GO:0043806 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043806 GO_function GO:0043849 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043849 GO_function GO:0046941 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046941 GO_function GO:0052858 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052858 GO_function GO:0090595 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090595 GO_process GO:0016024 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016024 GO_process GO:0046474 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046474 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 947496 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947496 HOGENOM HOG000026378 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000026378&db=HOGENOM6 InParanoid P26647 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P26647 IntAct P26647 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P26647* IntEnz 2.3.1.51 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.51 IntEnz 2.3.1.n4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.n4 InterPro IPR002123 http://www.ebi.ac.uk/interpro/entry/IPR002123 InterPro IPR004552 http://www.ebi.ac.uk/interpro/entry/IPR004552 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01004 http://www.genome.jp/dbget-bin/www_bget?ko01004 KEGG_Gene ecj:JW2986 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2986 KEGG_Gene eco:b3018 http://www.genome.jp/dbget-bin/www_bget?eco:b3018 KEGG_Orthology KO:K00655 http://www.genome.jp/dbget-bin/www_bget?KO:K00655 KEGG_Pathway ko00561 http://www.genome.jp/kegg-bin/show_pathway?ko00561 KEGG_Pathway ko00564 http://www.genome.jp/kegg-bin/show_pathway?ko00564 KEGG_Reaction rn:R02241 http://www.genome.jp/dbget-bin/www_bget?rn:R02241 KEGG_Reaction rn:R09381 http://www.genome.jp/dbget-bin/www_bget?rn:R09381 OMA MSIISWF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MSIISWF PSORT swissprot:PLSC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PLSC_ECOLI PSORT-B swissprot:PLSC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PLSC_ECOLI PSORT2 swissprot:PLSC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PLSC_ECOLI Pfam PF01553 http://pfam.xfam.org/family/PF01553 Phobius swissprot:PLSC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PLSC_ECOLI PhylomeDB P26647 http://phylomedb.org/?seqid=P26647 ProteinModelPortal P26647 http://www.proteinmodelportal.org/query/uniprot/P26647 PubMed 1557036 http://www.ncbi.nlm.nih.gov/pubmed/1557036 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16949372 http://www.ncbi.nlm.nih.gov/pubmed/16949372 PubMed 2211622 http://www.ncbi.nlm.nih.gov/pubmed/2211622 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417490 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417490 RefSeq WP_000965722 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000965722 SMART SM00563 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00563 SMR P26647 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P26647 STRING 511145.b3018 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3018&targetmode=cogs STRING COG0204 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0204&targetmode=cogs TIGRFAMs TIGR00530 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00530 UniProtKB PLSC_ECOLI http://www.uniprot.org/uniprot/PLSC_ECOLI UniProtKB-AC P26647 http://www.uniprot.org/uniprot/P26647 charge swissprot:PLSC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PLSC_ECOLI eggNOG COG0204 http://eggnogapi.embl.de/nog_data/html/tree/COG0204 eggNOG ENOG4107S7E http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107S7E epestfind swissprot:PLSC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PLSC_ECOLI garnier swissprot:PLSC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PLSC_ECOLI helixturnhelix swissprot:PLSC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PLSC_ECOLI hmoment swissprot:PLSC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PLSC_ECOLI iep swissprot:PLSC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PLSC_ECOLI inforesidue swissprot:PLSC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PLSC_ECOLI octanol swissprot:PLSC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PLSC_ECOLI pepcoil swissprot:PLSC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PLSC_ECOLI pepdigest swissprot:PLSC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PLSC_ECOLI pepinfo swissprot:PLSC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PLSC_ECOLI pepnet swissprot:PLSC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PLSC_ECOLI pepstats swissprot:PLSC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PLSC_ECOLI pepwheel swissprot:PLSC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PLSC_ECOLI pepwindow swissprot:PLSC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PLSC_ECOLI sigcleave swissprot:PLSC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PLSC_ECOLI ## Database ID URL or Descriptions # BioGrid 4260213 9 # COFACTOR YDEP_ECOLI Name=Mo-bis(molybdopterin guanine dinucleotide); Xref=ChEBI CHEBI 60539; Evidence={ECO 0000250}; Note=Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit. {ECO 0000250}; # COFACTOR YDEP_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000305}; Note=Binds 1 [4Fe-4S] cluster. {ECO 0000305}; # EcoGene EG13798 ydeP # FUNCTION YDEP_ECOLI Probably involved in acid resistance. {ECO 0000269|PubMed 12399493, ECO 0000269|PubMed 12694615}. # GO_function GO:0008863 formate dehydrogenase (NAD+) activity; IEA:InterPro. # GO_function GO:0030151 molybdenum ion binding; IEA:InterPro. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0010447 response to acidic pH; IMP:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # INDUCTION YDEP_ECOLI By EvgA. {ECO 0000269|PubMed 12399493, ECO 0000269|PubMed 12694615}. # IntAct P77561 11 # InterPro IPR006656 Mopterin_OxRdtase # InterPro IPR006657 MoPterin_dinucl-bd_dom # InterPro IPR009010 Asp_de-COase-like_dom # InterPro IPR010046 Mopterin_OxRdtse_a_bac # Organism YDEP_ECOLI Escherichia coli (strain K12) # PATRIC 32118296 VBIEscCol129921_1568 # PIR H64903 H64903 # PIRSF PIRSF000144 CbbBc # Pfam PF00384 Molybdopterin # Pfam PF01568 Molydop_binding # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDEP_ECOLI Protein YdeP # RefSeq NP_416018 NC_000913.3 # RefSeq WP_000726691 NZ_LN832404.1 # SIMILARITY Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. {ECO 0000305}. # SUPFAM SSF50692 SSF50692 # TIGRFAMs TIGR01701 Fdhalpha-like # eggNOG COG0243 LUCA # eggNOG ENOG4107QKC Bacteria BLAST swissprot:YDEP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDEP_ECOLI BioCyc ECOL316407:JW1495-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1495-MONOMER BioCyc EcoCyc:G6791-MONOMER http://biocyc.org/getid?id=EcoCyc:G6791-MONOMER DIP DIP-28057N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-28057N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2003.03477.x http://dx.doi.org/10.1046/j.1365-2958.2003.03477.x DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.22.6225-6234.2002 http://dx.doi.org/10.1128/JB.184.22.6225-6234.2002 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3559 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3559 EcoGene EG13798 http://www.ecogene.org/geneInfo.php?eg_id=EG13798 EnsemblBacteria AAC74574 http://www.ensemblgenomes.org/id/AAC74574 EnsemblBacteria AAC74574 http://www.ensemblgenomes.org/id/AAC74574 EnsemblBacteria BAA15174 http://www.ensemblgenomes.org/id/BAA15174 EnsemblBacteria BAA15174 http://www.ensemblgenomes.org/id/BAA15174 EnsemblBacteria BAA15174 http://www.ensemblgenomes.org/id/BAA15174 EnsemblBacteria b1501 http://www.ensemblgenomes.org/id/b1501 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008863 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008863 GO_function GO:0030151 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030151 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0010447 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010447 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 946055 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946055 HOGENOM HOG000200066 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000200066&db=HOGENOM6 InParanoid P77561 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77561 IntAct P77561 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77561* InterPro IPR006656 http://www.ebi.ac.uk/interpro/entry/IPR006656 InterPro IPR006657 http://www.ebi.ac.uk/interpro/entry/IPR006657 InterPro IPR009010 http://www.ebi.ac.uk/interpro/entry/IPR009010 InterPro IPR010046 http://www.ebi.ac.uk/interpro/entry/IPR010046 KEGG_Gene ecj:JW1495 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1495 KEGG_Gene eco:b1501 http://www.genome.jp/dbget-bin/www_bget?eco:b1501 OMA NRSHLLI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NRSHLLI PSORT swissprot:YDEP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDEP_ECOLI PSORT-B swissprot:YDEP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDEP_ECOLI PSORT2 swissprot:YDEP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDEP_ECOLI Pfam PF00384 http://pfam.xfam.org/family/PF00384 Pfam PF01568 http://pfam.xfam.org/family/PF01568 Phobius swissprot:YDEP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDEP_ECOLI PhylomeDB P77561 http://phylomedb.org/?seqid=P77561 ProteinModelPortal P77561 http://www.proteinmodelportal.org/query/uniprot/P77561 PubMed 12399493 http://www.ncbi.nlm.nih.gov/pubmed/12399493 PubMed 12694615 http://www.ncbi.nlm.nih.gov/pubmed/12694615 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416018 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416018 RefSeq WP_000726691 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000726691 STRING 511145.b1501 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1501&targetmode=cogs SUPFAM SSF50692 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50692 TIGRFAMs TIGR01701 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01701 UniProtKB YDEP_ECOLI http://www.uniprot.org/uniprot/YDEP_ECOLI UniProtKB-AC P77561 http://www.uniprot.org/uniprot/P77561 charge swissprot:YDEP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDEP_ECOLI eggNOG COG0243 http://eggnogapi.embl.de/nog_data/html/tree/COG0243 eggNOG ENOG4107QKC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QKC epestfind swissprot:YDEP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDEP_ECOLI garnier swissprot:YDEP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDEP_ECOLI helixturnhelix swissprot:YDEP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDEP_ECOLI hmoment swissprot:YDEP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDEP_ECOLI iep swissprot:YDEP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDEP_ECOLI inforesidue swissprot:YDEP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDEP_ECOLI octanol swissprot:YDEP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDEP_ECOLI pepcoil swissprot:YDEP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDEP_ECOLI pepdigest swissprot:YDEP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDEP_ECOLI pepinfo swissprot:YDEP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDEP_ECOLI pepnet swissprot:YDEP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDEP_ECOLI pepstats swissprot:YDEP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDEP_ECOLI pepwheel swissprot:YDEP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDEP_ECOLI pepwindow swissprot:YDEP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDEP_ECOLI sigcleave swissprot:YDEP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDEP_ECOLI ## Database ID URL or Descriptions # AltName FOLC_ECOLI Folylpoly-gamma-glutamate synthetase # AltName FOLC_ECOLI Tetrahydrofolylpolyglutamate synthase # BRENDA 6.3.2.17 2026 # BioGrid 4261362 387 # CATALYTIC ACTIVITY FOLC_ECOLI ATP + 7,8-dihydropteroate + L-glutamate = ADP + phosphate + 7,8-dihydropteroylglutamate. # CATALYTIC ACTIVITY FOLC_ECOLI ATP + tetrahydropteroyl-(gamma-Glu)(n) + L- glutamate = ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1). # DrugBank DB01015 Sulfamethoxazole # EcoGene EG10327 folC # FUNCTION FOLC_ECOLI Conversion of folates to polyglutamate derivatives. # GO_component GO:0005737 cytoplasm; IDA:EcoCyc. # GO_function GO:0004326 tetrahydrofolylpolyglutamate synthase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0008841 dihydrofolate synthase activity; IDA:EcoCyc. # GO_process GO:0006730 one-carbon metabolic process; IEA:UniProtKB-KW. # GO_process GO:0046654 tetrahydrofolate biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0046656 folic acid biosynthetic process; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.1190.10 -; 1. # Gene3D 3.90.190.20 -; 1. # IntAct P08192 9 # InterPro IPR001645 Folylpolyglutamate_synth # InterPro IPR004101 Mur_ligase_C # InterPro IPR013221 Mur_ligase_cen # InterPro IPR018109 Folylpolyglutamate_synth_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00790 Folate biosynthesis # Organism FOLC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11136 PTHR11136 # PATHWAY Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8- dihydropteridine diphosphate and 4-aminobenzoate step 2/2. # PATRIC 32120001 VBIEscCol129921_2410 # PDB 1W78 X-ray; 1.82 A; A=1-422 # PDB 1W7K X-ray; 2.10 A; A=1-422 # PIR A65004 SYECFG # PIRSF PIRSF001563 Folylpolyglu_synth # PROSITE PS01011 FOLYLPOLYGLU_SYNT_1 # PROSITE PS01012 FOLYLPOLYGLU_SYNT_2 # Pfam PF02875 Mur_ligase_C # Pfam PF08245 Mur_ligase_M # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FOLC_ECOLI Bifunctional protein FolC # RecName FOLC_ECOLI Bifunctional protein FolC # RecName FOLC_ECOLI Dihydrofolate synthase # RecName FOLC_ECOLI Folylpolyglutamate synthase # RefSeq NP_416818 NC_000913.3 # RefSeq WP_000584546 NZ_LN832404.1 # SIMILARITY Belongs to the folylpolyglutamate synthase family. {ECO 0000305}. # SUBUNIT FOLC_ECOLI Monomer. # SUPFAM SSF53244 SSF53244 # SUPFAM SSF53623 SSF53623 # TIGRFAMs TIGR01499 folC # UniPathway UPA00077 UER00157 # eggNOG COG0285 LUCA # eggNOG ENOG4105DPM Bacteria BLAST swissprot:FOLC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FOLC_ECOLI BioCyc ECOL316407:JW2312-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2312-MONOMER BioCyc EcoCyc:FOLC-MONOMER http://biocyc.org/getid?id=EcoCyc:FOLC-MONOMER BioCyc MetaCyc:FOLC-MONOMER http://biocyc.org/getid?id=MetaCyc:FOLC-MONOMER COG COG0285 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0285 DIP DIP-9674N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9674N DOI 10.1016/0003-9861(91)90254-G http://dx.doi.org/10.1016/0003-9861(91)90254-G DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB01015 http://www.drugbank.ca/drugs/DB01015 EC_number EC:6.3.2.12 http://www.genome.jp/dbget-bin/www_bget?EC:6.3.2.12 EC_number EC:6.3.2.17 http://www.genome.jp/dbget-bin/www_bget?EC:6.3.2.17 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J02808 http://www.ebi.ac.uk/ena/data/view/J02808 EMBL M32445 http://www.ebi.ac.uk/ena/data/view/M32445 EMBL M68934 http://www.ebi.ac.uk/ena/data/view/M68934 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 6.3.2.12 http://enzyme.expasy.org/EC/6.3.2.12 ENZYME 6.3.2.17 http://enzyme.expasy.org/EC/6.3.2.17 EchoBASE EB0323 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0323 EcoGene EG10327 http://www.ecogene.org/geneInfo.php?eg_id=EG10327 EnsemblBacteria AAC75375 http://www.ensemblgenomes.org/id/AAC75375 EnsemblBacteria AAC75375 http://www.ensemblgenomes.org/id/AAC75375 EnsemblBacteria BAA16164 http://www.ensemblgenomes.org/id/BAA16164 EnsemblBacteria BAA16164 http://www.ensemblgenomes.org/id/BAA16164 EnsemblBacteria BAA16164 http://www.ensemblgenomes.org/id/BAA16164 EnsemblBacteria b2315 http://www.ensemblgenomes.org/id/b2315 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004326 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004326 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008841 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008841 GO_process GO:0006730 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006730 GO_process GO:0046654 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046654 GO_process GO:0046656 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046656 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.1190.10 http://www.cathdb.info/version/latest/superfamily/3.40.1190.10 Gene3D 3.90.190.20 http://www.cathdb.info/version/latest/superfamily/3.90.190.20 GeneID 945451 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945451 HOGENOM HOG000019982 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000019982&db=HOGENOM6 InParanoid P08192 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P08192 IntAct P08192 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P08192* IntEnz 6.3.2.12 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.2.12 IntEnz 6.3.2.17 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.2.17 InterPro IPR001645 http://www.ebi.ac.uk/interpro/entry/IPR001645 InterPro IPR004101 http://www.ebi.ac.uk/interpro/entry/IPR004101 InterPro IPR013221 http://www.ebi.ac.uk/interpro/entry/IPR013221 InterPro IPR018109 http://www.ebi.ac.uk/interpro/entry/IPR018109 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2312 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2312 KEGG_Gene eco:b2315 http://www.genome.jp/dbget-bin/www_bget?eco:b2315 KEGG_Orthology KO:K11754 http://www.genome.jp/dbget-bin/www_bget?KO:K11754 KEGG_Pathway ko00790 http://www.genome.jp/kegg-bin/show_pathway?ko00790 KEGG_Reaction rn:R00942 http://www.genome.jp/dbget-bin/www_bget?rn:R00942 KEGG_Reaction rn:R02237 http://www.genome.jp/dbget-bin/www_bget?rn:R02237 MINT MINT-1301447 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1301447 OMA FHALENI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FHALENI PANTHER PTHR11136 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11136 PDB 1W78 http://www.ebi.ac.uk/pdbe-srv/view/entry/1W78 PDB 1W7K http://www.ebi.ac.uk/pdbe-srv/view/entry/1W7K PDBsum 1W78 http://www.ebi.ac.uk/pdbsum/1W78 PDBsum 1W7K http://www.ebi.ac.uk/pdbsum/1W7K PROSITE PS01011 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01011 PROSITE PS01012 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01012 PSORT swissprot:FOLC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FOLC_ECOLI PSORT-B swissprot:FOLC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FOLC_ECOLI PSORT2 swissprot:FOLC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FOLC_ECOLI Pfam PF02875 http://pfam.xfam.org/family/PF02875 Pfam PF08245 http://pfam.xfam.org/family/PF08245 Phobius swissprot:FOLC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FOLC_ECOLI PhylomeDB P08192 http://phylomedb.org/?seqid=P08192 ProteinModelPortal P08192 http://www.proteinmodelportal.org/query/uniprot/P08192 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1989505 http://www.ncbi.nlm.nih.gov/pubmed/1989505 PubMed 3040734 http://www.ncbi.nlm.nih.gov/pubmed/3040734 PubMed 3040739 http://www.ncbi.nlm.nih.gov/pubmed/3040739 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416818 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416818 RefSeq WP_000584546 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000584546 SMR P08192 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P08192 STRING 511145.b2315 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2315&targetmode=cogs STRING COG0285 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0285&targetmode=cogs SUPFAM SSF53244 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53244 SUPFAM SSF53623 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53623 TIGRFAMs TIGR01499 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01499 UniProtKB FOLC_ECOLI http://www.uniprot.org/uniprot/FOLC_ECOLI UniProtKB-AC P08192 http://www.uniprot.org/uniprot/P08192 charge swissprot:FOLC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FOLC_ECOLI eggNOG COG0285 http://eggnogapi.embl.de/nog_data/html/tree/COG0285 eggNOG ENOG4105DPM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DPM epestfind swissprot:FOLC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FOLC_ECOLI garnier swissprot:FOLC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FOLC_ECOLI helixturnhelix swissprot:FOLC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FOLC_ECOLI hmoment swissprot:FOLC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FOLC_ECOLI iep swissprot:FOLC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FOLC_ECOLI inforesidue swissprot:FOLC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FOLC_ECOLI octanol swissprot:FOLC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FOLC_ECOLI pepcoil swissprot:FOLC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FOLC_ECOLI pepdigest swissprot:FOLC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FOLC_ECOLI pepinfo swissprot:FOLC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FOLC_ECOLI pepnet swissprot:FOLC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FOLC_ECOLI pepstats swissprot:FOLC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FOLC_ECOLI pepwheel swissprot:FOLC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FOLC_ECOLI pepwindow swissprot:FOLC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FOLC_ECOLI sigcleave swissprot:FOLC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FOLC_ECOLI ## Database ID URL or Descriptions # BioGrid 4260787 5 # COFACTOR PQQL_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000250}; Note=Binds 1 zinc ion per subunit. {ECO 0000250}; # EcoGene EG11744 pqqL # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004222 metalloendopeptidase activity; IBA:GO_Central. # GO_function GO:0008270 zinc ion binding; IBA:GO_Central. # GO_process GO:0016485 protein processing; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0051604 protein maturation # Gene3D 3.30.830.10 -; 4. # IntAct P31828 7 # InterPro IPR001431 Pept_M16_Zn_BS # InterPro IPR007863 Peptidase_M16_C # InterPro IPR011237 Pept_M16_dom # InterPro IPR011249 Metalloenz_LuxS/M16 # InterPro IPR011765 Pept_M16_N # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # Organism PQQL_ECOLI Escherichia coli (strain K12) # PATRIC 32118282 VBIEscCol129921_1561 # PIR A64903 A64903 # PROSITE PS00143 INSULINASE # Pfam PF00675 Peptidase_M16 # Pfam PF05193 Peptidase_M16_C; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PQQL_ECOLI Probable zinc protease PqqL # RefSeq NP_416011 NC_000913.3 # SEQUENCE CAUTION Sequence=CAA50735.1; Type=Frameshift; Positions=651; Note=Produces two separate ORFs.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the peptidase M16 family. {ECO 0000305}. # SUPFAM SSF63411 SSF63411; 4 # eggNOG COG0612 LUCA # eggNOG ENOG4107RAN Bacteria BLAST swissprot:PQQL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PQQL_ECOLI BioCyc ECOL316407:JW1489-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1489-MONOMER BioCyc EcoCyc:EG11744-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11744-MONOMER COG COG0612 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0612 DIP DIP-10556N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10556N DOI 10.1016/S0300-9084(97)84334-9 http://dx.doi.org/10.1016/S0300-9084(97)84334-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.24.- http://www.genome.jp/dbget-bin/www_bget?EC:3.4.24.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X71917 http://www.ebi.ac.uk/ena/data/view/X71917 EMBL X71917 http://www.ebi.ac.uk/ena/data/view/X71917 ENZYME 3.4.24.- http://enzyme.expasy.org/EC/3.4.24.- EchoBASE EB1695 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1695 EcoGene EG11744 http://www.ecogene.org/geneInfo.php?eg_id=EG11744 EnsemblBacteria AAC74567 http://www.ensemblgenomes.org/id/AAC74567 EnsemblBacteria AAC74567 http://www.ensemblgenomes.org/id/AAC74567 EnsemblBacteria BAA15164 http://www.ensemblgenomes.org/id/BAA15164 EnsemblBacteria BAA15164 http://www.ensemblgenomes.org/id/BAA15164 EnsemblBacteria BAA15164 http://www.ensemblgenomes.org/id/BAA15164 EnsemblBacteria b1494 http://www.ensemblgenomes.org/id/b1494 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004222 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004222 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_process GO:0016485 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016485 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 Gene3D 3.30.830.10 http://www.cathdb.info/version/latest/superfamily/3.30.830.10 GeneID 946059 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946059 HOGENOM HOG000120686 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120686&db=HOGENOM6 InParanoid P31828 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31828 IntAct P31828 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31828* IntEnz 3.4.24 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.24 InterPro IPR001431 http://www.ebi.ac.uk/interpro/entry/IPR001431 InterPro IPR007863 http://www.ebi.ac.uk/interpro/entry/IPR007863 InterPro IPR011237 http://www.ebi.ac.uk/interpro/entry/IPR011237 InterPro IPR011249 http://www.ebi.ac.uk/interpro/entry/IPR011249 InterPro IPR011765 http://www.ebi.ac.uk/interpro/entry/IPR011765 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW1489 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1489 KEGG_Gene eco:b1494 http://www.genome.jp/dbget-bin/www_bget?eco:b1494 KEGG_Orthology KO:K07263 http://www.genome.jp/dbget-bin/www_bget?KO:K07263 OMA FYQTWYQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FYQTWYQ PROSITE PS00143 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00143 PSORT swissprot:PQQL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PQQL_ECOLI PSORT-B swissprot:PQQL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PQQL_ECOLI PSORT2 swissprot:PQQL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PQQL_ECOLI Pfam PF00675 http://pfam.xfam.org/family/PF00675 Pfam PF05193 http://pfam.xfam.org/family/PF05193 Phobius swissprot:PQQL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PQQL_ECOLI PhylomeDB P31828 http://phylomedb.org/?seqid=P31828 ProteinModelPortal P31828 http://www.proteinmodelportal.org/query/uniprot/P31828 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9116051 http://www.ncbi.nlm.nih.gov/pubmed/9116051 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416011 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416011 SMR P31828 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31828 STRING 511145.b1494 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1494&targetmode=cogs STRING COG0612 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0612&targetmode=cogs SUPFAM SSF63411 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63411 UniProtKB PQQL_ECOLI http://www.uniprot.org/uniprot/PQQL_ECOLI UniProtKB-AC P31828 http://www.uniprot.org/uniprot/P31828 charge swissprot:PQQL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PQQL_ECOLI eggNOG COG0612 http://eggnogapi.embl.de/nog_data/html/tree/COG0612 eggNOG ENOG4107RAN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107RAN epestfind swissprot:PQQL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PQQL_ECOLI garnier swissprot:PQQL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PQQL_ECOLI helixturnhelix swissprot:PQQL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PQQL_ECOLI hmoment swissprot:PQQL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PQQL_ECOLI iep swissprot:PQQL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PQQL_ECOLI inforesidue swissprot:PQQL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PQQL_ECOLI octanol swissprot:PQQL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PQQL_ECOLI pepcoil swissprot:PQQL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PQQL_ECOLI pepdigest swissprot:PQQL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PQQL_ECOLI pepinfo swissprot:PQQL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PQQL_ECOLI pepnet swissprot:PQQL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PQQL_ECOLI pepstats swissprot:PQQL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PQQL_ECOLI pepwheel swissprot:PQQL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PQQL_ECOLI pepwindow swissprot:PQQL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PQQL_ECOLI sigcleave swissprot:PQQL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PQQL_ECOLI ## Database ID URL or Descriptions # BioGrid 4260939 10 # DISRUPTION PHENOTYPE Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain. {ECO:0000269|PubMed 20345943}. # EcoGene EG14118 yfcO # FUNCTION YFCO_ECOLI Part of the yfcOPQRSUV fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes. {ECO 0000269|PubMed 20345943}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # INDUCTION Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression. {ECO:0000269|PubMed 20345943}. # InterPro IPR021407 DUF2544 # MISCELLANEOUS The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed. {ECO:0000305|PubMed 20345943}. # Organism YFCO_ECOLI Escherichia coli (strain K12) # PATRIC 32120037 VBIEscCol129921_2428 # PIR B65006 B65006 # Pfam PF11245 DUF2544 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFCO_ECOLI Uncharacterized protein YfcO # RefSeq NP_416835 NC_000913.3 # RefSeq WP_000698745 NZ_LN832404.1 # SIMILARITY To S.typhimurium YadU. {ECO 0000305}. BLAST swissprot:YFCO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFCO_ECOLI BioCyc ECOL316407:JW2329-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2329-MONOMER BioCyc EcoCyc:G7203-MONOMER http://biocyc.org/getid?id=EcoCyc:G7203-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1462-2920.2010.02202.x http://dx.doi.org/10.1111/j.1462-2920.2010.02202.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3871 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3871 EcoGene EG14118 http://www.ecogene.org/geneInfo.php?eg_id=EG14118 EnsemblBacteria AAC75392 http://www.ensemblgenomes.org/id/AAC75392 EnsemblBacteria AAC75392 http://www.ensemblgenomes.org/id/AAC75392 EnsemblBacteria BAE76689 http://www.ensemblgenomes.org/id/BAE76689 EnsemblBacteria BAE76689 http://www.ensemblgenomes.org/id/BAE76689 EnsemblBacteria BAE76689 http://www.ensemblgenomes.org/id/BAE76689 EnsemblBacteria b2332 http://www.ensemblgenomes.org/id/b2332 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GeneID 946620 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946620 HOGENOM HOG000122502 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122502&db=HOGENOM6 InterPro IPR021407 http://www.ebi.ac.uk/interpro/entry/IPR021407 KEGG_Gene ecj:JW2329 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2329 KEGG_Gene eco:b2332 http://www.genome.jp/dbget-bin/www_bget?eco:b2332 OMA MMKIIRT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MMKIIRT PSORT swissprot:YFCO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFCO_ECOLI PSORT-B swissprot:YFCO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFCO_ECOLI PSORT2 swissprot:YFCO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFCO_ECOLI Pfam PF11245 http://pfam.xfam.org/family/PF11245 Phobius swissprot:YFCO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFCO_ECOLI ProteinModelPortal P76498 http://www.proteinmodelportal.org/query/uniprot/P76498 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20345943 http://www.ncbi.nlm.nih.gov/pubmed/20345943 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416835 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416835 RefSeq WP_000698745 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000698745 STRING 511145.b2332 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2332&targetmode=cogs UniProtKB YFCO_ECOLI http://www.uniprot.org/uniprot/YFCO_ECOLI UniProtKB-AC P76498 http://www.uniprot.org/uniprot/P76498 charge swissprot:YFCO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFCO_ECOLI epestfind swissprot:YFCO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFCO_ECOLI garnier swissprot:YFCO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFCO_ECOLI helixturnhelix swissprot:YFCO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFCO_ECOLI hmoment swissprot:YFCO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFCO_ECOLI iep swissprot:YFCO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFCO_ECOLI inforesidue swissprot:YFCO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFCO_ECOLI octanol swissprot:YFCO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFCO_ECOLI pepcoil swissprot:YFCO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFCO_ECOLI pepdigest swissprot:YFCO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFCO_ECOLI pepinfo swissprot:YFCO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFCO_ECOLI pepnet swissprot:YFCO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFCO_ECOLI pepstats swissprot:YFCO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFCO_ECOLI pepwheel swissprot:YFCO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFCO_ECOLI pepwindow swissprot:YFCO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFCO_ECOLI sigcleave swissprot:YFCO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFCO_ECOLI ## Database ID URL or Descriptions # BioGrid 4259262 13 # EcoGene EG12752 yhaM # HAMAP MF_01845 UPF0597 # InterPro IPR005130 Ser_deHydtase-like_asu # InterPro IPR021144 UPF0597 # Organism YHAM_ECOLI Escherichia coli (strain K12) # PATRIC 32121636 VBIEscCol129921_3204 # PIRSF PIRSF006054 UCP006054 # Pfam PF03313 SDH_alpha # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UPF0597 protein YhaM {ECO:0000255|HAMAP-Rule MF_01845} # RefSeq WP_000460499 NZ_LN832404.1 # RefSeq YP_026202 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA57912.1; Type=Frameshift; Positions=185; Evidence={ECO:0000305}; Sequence=AAA57913.1; Type=Frameshift; Positions=185; Evidence={ECO 0000305}; # SIMILARITY Belongs to the UPF0597 family. {ECO:0000255|HAMAP- Rule MF_01845}. # eggNOG COG3681 LUCA # eggNOG ENOG4105CEM Bacteria BLAST swissprot:YHAM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHAM_ECOLI BioCyc ECOL316407:JW5518-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5518-MONOMER BioCyc EcoCyc:G7622-MONOMER http://biocyc.org/getid?id=EcoCyc:G7622-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2608 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2608 EcoGene EG12752 http://www.ecogene.org/geneInfo.php?eg_id=EG12752 EnsemblBacteria AAT48167 http://www.ensemblgenomes.org/id/AAT48167 EnsemblBacteria AAT48167 http://www.ensemblgenomes.org/id/AAT48167 EnsemblBacteria BAE77158 http://www.ensemblgenomes.org/id/BAE77158 EnsemblBacteria BAE77158 http://www.ensemblgenomes.org/id/BAE77158 EnsemblBacteria BAE77158 http://www.ensemblgenomes.org/id/BAE77158 EnsemblBacteria b4470 http://www.ensemblgenomes.org/id/b4470 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 2847723 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2847723 HAMAP MF_01845 http://hamap.expasy.org/unirule/MF_01845 HOGENOM HOG000237280 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000237280&db=HOGENOM6 InParanoid P42626 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P42626 InterPro IPR005130 http://www.ebi.ac.uk/interpro/entry/IPR005130 InterPro IPR021144 http://www.ebi.ac.uk/interpro/entry/IPR021144 KEGG_Gene ecj:JW5518 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5518 KEGG_Gene eco:b4470 http://www.genome.jp/dbget-bin/www_bget?eco:b4470 OMA YIKQSLG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YIKQSLG PSORT swissprot:YHAM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHAM_ECOLI PSORT-B swissprot:YHAM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHAM_ECOLI PSORT2 swissprot:YHAM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHAM_ECOLI Pfam PF03313 http://pfam.xfam.org/family/PF03313 Phobius swissprot:YHAM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHAM_ECOLI PhylomeDB P42626 http://phylomedb.org/?seqid=P42626 ProteinModelPortal P42626 http://www.proteinmodelportal.org/query/uniprot/P42626 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000460499 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000460499 RefSeq YP_026202 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026202 STRING 511145.b4470 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4470&targetmode=cogs UniProtKB YHAM_ECOLI http://www.uniprot.org/uniprot/YHAM_ECOLI UniProtKB-AC P42626 http://www.uniprot.org/uniprot/P42626 charge swissprot:YHAM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHAM_ECOLI eggNOG COG3681 http://eggnogapi.embl.de/nog_data/html/tree/COG3681 eggNOG ENOG4105CEM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CEM epestfind swissprot:YHAM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHAM_ECOLI garnier swissprot:YHAM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHAM_ECOLI helixturnhelix swissprot:YHAM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHAM_ECOLI hmoment swissprot:YHAM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHAM_ECOLI iep swissprot:YHAM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHAM_ECOLI inforesidue swissprot:YHAM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHAM_ECOLI octanol swissprot:YHAM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHAM_ECOLI pepcoil swissprot:YHAM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHAM_ECOLI pepdigest swissprot:YHAM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHAM_ECOLI pepinfo swissprot:YHAM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHAM_ECOLI pepnet swissprot:YHAM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHAM_ECOLI pepstats swissprot:YHAM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHAM_ECOLI pepwheel swissprot:YHAM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHAM_ECOLI pepwindow swissprot:YHAM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHAM_ECOLI sigcleave swissprot:YHAM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHAM_ECOLI ## Database ID URL or Descriptions # BioGrid 4261990 155 # EcoGene EG12779 yraN # GO_function GO:0003676 nucleic acid binding; IEA:InterPro. # GO_function GO:0004518 nuclease activity; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0004518 nuclease activity # Gene3D 3.40.1350.10 -; 1. # HAMAP MF_00048 UPF0102 # IntAct P45465 21 # InterPro IPR003509 UPF0102 # InterPro IPR011335 Restrct_endonuc-II-like # InterPro IPR011856 tRNA_endonuc-like_dom # Organism YRAN_ECOLI Escherichia coli (strain K12) # PATRIC 32121714 VBIEscCol129921_3243 # PIR H65104 H65104 # Pfam PF02021 UPF0102 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YRAN_ECOLI UPF0102 protein YraN # RefSeq NP_417617 NC_000913.3 # RefSeq WP_000246830 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0102 family. {ECO 0000305}. # SUPFAM SSF52980 SSF52980 # TIGRFAMs TIGR00252 TIGR00252 # eggNOG COG0792 LUCA # eggNOG ENOG41082RQ Bacteria BLAST swissprot:YRAN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YRAN_ECOLI BioCyc ECOL316407:JW3117-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3117-MONOMER BioCyc EcoCyc:G7643-MONOMER http://biocyc.org/getid?id=EcoCyc:G7643-MONOMER COG COG0792 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0792 DIP DIP-12898N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12898N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2632 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2632 EcoGene EG12779 http://www.ecogene.org/geneInfo.php?eg_id=EG12779 EnsemblBacteria AAC76182 http://www.ensemblgenomes.org/id/AAC76182 EnsemblBacteria AAC76182 http://www.ensemblgenomes.org/id/AAC76182 EnsemblBacteria BAE77194 http://www.ensemblgenomes.org/id/BAE77194 EnsemblBacteria BAE77194 http://www.ensemblgenomes.org/id/BAE77194 EnsemblBacteria BAE77194 http://www.ensemblgenomes.org/id/BAE77194 EnsemblBacteria b3148 http://www.ensemblgenomes.org/id/b3148 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003676 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003676 GO_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 Gene3D 3.40.1350.10 http://www.cathdb.info/version/latest/superfamily/3.40.1350.10 GeneID 947662 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947662 HAMAP MF_00048 http://hamap.expasy.org/unirule/MF_00048 HOGENOM HOG000016278 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000016278&db=HOGENOM6 InParanoid P45465 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45465 IntAct P45465 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45465* InterPro IPR003509 http://www.ebi.ac.uk/interpro/entry/IPR003509 InterPro IPR011335 http://www.ebi.ac.uk/interpro/entry/IPR011335 InterPro IPR011856 http://www.ebi.ac.uk/interpro/entry/IPR011856 KEGG_Gene ecj:JW3117 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3117 KEGG_Gene eco:b3148 http://www.genome.jp/dbget-bin/www_bget?eco:b3148 KEGG_Orthology KO:K07460 http://www.genome.jp/dbget-bin/www_bget?KO:K07460 MINT MINT-1244192 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1244192 OMA WRCKGGE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WRCKGGE PSORT swissprot:YRAN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YRAN_ECOLI PSORT-B swissprot:YRAN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YRAN_ECOLI PSORT2 swissprot:YRAN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YRAN_ECOLI Pfam PF02021 http://pfam.xfam.org/family/PF02021 Phobius swissprot:YRAN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YRAN_ECOLI PhylomeDB P45465 http://phylomedb.org/?seqid=P45465 ProteinModelPortal P45465 http://www.proteinmodelportal.org/query/uniprot/P45465 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417617 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417617 RefSeq WP_000246830 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000246830 SMR P45465 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45465 STRING 511145.b3148 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3148&targetmode=cogs STRING COG0792 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0792&targetmode=cogs SUPFAM SSF52980 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52980 TIGRFAMs TIGR00252 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00252 UniProtKB YRAN_ECOLI http://www.uniprot.org/uniprot/YRAN_ECOLI UniProtKB-AC P45465 http://www.uniprot.org/uniprot/P45465 charge swissprot:YRAN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YRAN_ECOLI eggNOG COG0792 http://eggnogapi.embl.de/nog_data/html/tree/COG0792 eggNOG ENOG41082RQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG41082RQ epestfind swissprot:YRAN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YRAN_ECOLI garnier swissprot:YRAN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YRAN_ECOLI helixturnhelix swissprot:YRAN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YRAN_ECOLI hmoment swissprot:YRAN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YRAN_ECOLI iep swissprot:YRAN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YRAN_ECOLI inforesidue swissprot:YRAN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YRAN_ECOLI octanol swissprot:YRAN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YRAN_ECOLI pepcoil swissprot:YRAN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YRAN_ECOLI pepdigest swissprot:YRAN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YRAN_ECOLI pepinfo swissprot:YRAN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YRAN_ECOLI pepnet swissprot:YRAN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YRAN_ECOLI pepstats swissprot:YRAN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YRAN_ECOLI pepwheel swissprot:YRAN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YRAN_ECOLI pepwindow swissprot:YRAN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YRAN_ECOLI sigcleave swissprot:YRAN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YRAN_ECOLI ## Database ID URL or Descriptions # AltName HYCE_ECOLI Hydrogenase-3 component E # BioGrid 4261447 7 # COFACTOR HYCE_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000305}; Note=Binds 1 [4Fe-4S] cluster. {ECO 0000305}; # COFACTOR Name=Ni(2+); Xref=ChEBI:CHEBI 49786; Evidence={ECO:0000305}; # EcoGene EG10478 hycE # GO_function GO:0008137 NADH dehydrogenase (ubiquinone) activity; IEA:InterPro. # GO_function GO:0016151 nickel cation binding; IDA:EcoCyc. # GO_function GO:0048038 quinone binding; IEA:InterPro. # GO_function GO:0051287 NAD binding; IEA:InterPro. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # Gene3D 1.10.645.10 -; 1. # INTERACTION HYCE_ECOLI P0A700 hypA; NbExp=14; IntAct=EBI-552702, EBI-6290024; P0A9K9 slyD; NbExp=7; IntAct=EBI-552702, EBI-369251; # IntAct P16431 18 # InterPro IPR001135 NADH_Q_OxRdtase_suD # InterPro IPR001268 NADH_UbQ_OxRdtase_30kDa_su # InterPro IPR001501 Ni-dep_hyd_lsu # InterPro IPR014029 NADH_UbQ_OxRdtase_49kDa_CS # InterPro IPR029014 NiFe_Hase-like # Organism HYCE_ECOLI Escherichia coli (strain K12) # PATRIC 32120842 VBIEscCol129921_2813 # PIR S08623 S08623 # PROSITE PS00535 COMPLEX1_49K # Pfam PF00329 Complex1_30kDa # Pfam PF00346 Complex1_49kDa; 2 # Pfam PF00374 NiFeSe_Hases # ProDom PD001581 NADH_UbQ_OxRdtase_30kDa_su # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HYCE_ECOLI Formate hydrogenlyase subunit 5 # RefSeq NP_417201 NC_000913.3 # RefSeq WP_001288122 NZ_LN832404.1 # SIMILARITY Belongs to the complex I 49 kDa subunit family. {ECO 0000305}. # SUBUNIT HYCE_ECOLI FHL comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (isoenzyme 3). In this non- energy conserving pathway molecular hydrogen and carbodioxide from formate are released. # SUPFAM SSF56762 SSF56762 # TCDB 3.D.1.9 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family # eggNOG COG3261 LUCA # eggNOG COG3262 LUCA # eggNOG ENOG4105CQV Bacteria BLAST swissprot:HYCE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HYCE_ECOLI BioCyc ECOL316407:JW2691-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2691-MONOMER BioCyc EcoCyc:HYCELARGE-MONOMER http://biocyc.org/getid?id=EcoCyc:HYCELARGE-MONOMER BioCyc MetaCyc:HYCELARGE-MONOMER http://biocyc.org/getid?id=MetaCyc:HYCELARGE-MONOMER COG COG3261 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3261 COG COG3262 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3262 DIP DIP-9975N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9975N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1990.tb00590.x http://dx.doi.org/10.1111/j.1365-2958.1990.tb00590.x DOI 10.1111/j.1432-1033.1994.tb18634.x http://dx.doi.org/10.1111/j.1432-1033.1994.tb18634.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EMBL X17506 http://www.ebi.ac.uk/ena/data/view/X17506 EchoBASE EB0473 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0473 EcoGene EG10478 http://www.ecogene.org/geneInfo.php?eg_id=EG10478 EnsemblBacteria AAC75763 http://www.ensemblgenomes.org/id/AAC75763 EnsemblBacteria AAC75763 http://www.ensemblgenomes.org/id/AAC75763 EnsemblBacteria BAE76798 http://www.ensemblgenomes.org/id/BAE76798 EnsemblBacteria BAE76798 http://www.ensemblgenomes.org/id/BAE76798 EnsemblBacteria BAE76798 http://www.ensemblgenomes.org/id/BAE76798 EnsemblBacteria b2721 http://www.ensemblgenomes.org/id/b2721 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008137 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008137 GO_function GO:0016151 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016151 GO_function GO:0048038 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048038 GO_function GO:0051287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051287 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 1.10.645.10 http://www.cathdb.info/version/latest/superfamily/1.10.645.10 GeneID 947396 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947396 HOGENOM HOG000228262 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000228262&db=HOGENOM6 InParanoid P16431 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P16431 IntAct P16431 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P16431* InterPro IPR001135 http://www.ebi.ac.uk/interpro/entry/IPR001135 InterPro IPR001268 http://www.ebi.ac.uk/interpro/entry/IPR001268 InterPro IPR001501 http://www.ebi.ac.uk/interpro/entry/IPR001501 InterPro IPR014029 http://www.ebi.ac.uk/interpro/entry/IPR014029 InterPro IPR029014 http://www.ebi.ac.uk/interpro/entry/IPR029014 KEGG_Gene ecj:JW2691 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2691 KEGG_Gene eco:b2721 http://www.genome.jp/dbget-bin/www_bget?eco:b2721 KEGG_Orthology KO:K15830 http://www.genome.jp/dbget-bin/www_bget?KO:K15830 MINT MINT-1223046 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1223046 OMA GEWRNEA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GEWRNEA PROSITE PS00535 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00535 PSORT swissprot:HYCE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HYCE_ECOLI PSORT-B swissprot:HYCE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HYCE_ECOLI PSORT2 swissprot:HYCE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HYCE_ECOLI Pfam PF00329 http://pfam.xfam.org/family/PF00329 Pfam PF00346 http://pfam.xfam.org/family/PF00346 Pfam PF00374 http://pfam.xfam.org/family/PF00374 Phobius swissprot:HYCE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HYCE_ECOLI PhylomeDB P16431 http://phylomedb.org/?seqid=P16431 ProteinModelPortal P16431 http://www.proteinmodelportal.org/query/uniprot/P16431 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2187144 http://www.ncbi.nlm.nih.gov/pubmed/2187144 PubMed 8125094 http://www.ncbi.nlm.nih.gov/pubmed/8125094 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417201 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417201 RefSeq WP_001288122 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001288122 SMR P16431 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P16431 STRING 511145.b2721 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2721&targetmode=cogs STRING COG3261 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3261&targetmode=cogs STRING COG3262 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3262&targetmode=cogs SUPFAM SSF56762 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56762 TCDB 3.D.1.9 http://www.tcdb.org/search/result.php?tc=3.D.1.9 UniProtKB HYCE_ECOLI http://www.uniprot.org/uniprot/HYCE_ECOLI UniProtKB-AC P16431 http://www.uniprot.org/uniprot/P16431 charge swissprot:HYCE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HYCE_ECOLI eggNOG COG3261 http://eggnogapi.embl.de/nog_data/html/tree/COG3261 eggNOG COG3262 http://eggnogapi.embl.de/nog_data/html/tree/COG3262 eggNOG ENOG4105CQV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CQV epestfind swissprot:HYCE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HYCE_ECOLI garnier swissprot:HYCE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HYCE_ECOLI helixturnhelix swissprot:HYCE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HYCE_ECOLI hmoment swissprot:HYCE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HYCE_ECOLI iep swissprot:HYCE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HYCE_ECOLI inforesidue swissprot:HYCE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HYCE_ECOLI octanol swissprot:HYCE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HYCE_ECOLI pepcoil swissprot:HYCE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HYCE_ECOLI pepdigest swissprot:HYCE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HYCE_ECOLI pepinfo swissprot:HYCE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HYCE_ECOLI pepnet swissprot:HYCE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HYCE_ECOLI pepstats swissprot:HYCE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HYCE_ECOLI pepwheel swissprot:HYCE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HYCE_ECOLI pepwindow swissprot:HYCE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HYCE_ECOLI sigcleave swissprot:HYCE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HYCE_ECOLI ## Database ID URL or Descriptions # AltName Formyl-FH(4) hydrolase {ECO:0000255|HAMAP-Rule MF_01927} # BioGrid 4261924 11 # CATALYTIC ACTIVITY PURU_ECOLI 10-formyltetrahydrofolate + H(2)O = formate + tetrahydrofolate. {ECO 0000255|HAMAP-Rule MF_01927, ECO 0000269|PubMed 7868604}. # ENZYME REGULATION Activated by methionine, inhibited by glycine. {ECO:0000269|PubMed 7868604}. # EcoGene EG11819 purU # FUNCTION PURU_ECOLI Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). Provides the major source of formate for the PurT-dependent synthesis of 5'- phosphoribosyl-N-formylglycinamide (FGAR) during aerobic growth. Has a role in regulating the one-carbon pool. {ECO 0000255|HAMAP- Rule MF_01927, ECO 0000269|PubMed 7868604}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008864 formyltetrahydrofolate deformylase activity; IDA:EcoCyc. # GO_function GO:0016597 amino acid binding; IEA:InterPro. # GO_function GO:0016742 hydroxymethyl-, formyl- and related transferase activity; IEA:InterPro. # GO_process GO:0006164 purine nucleotide biosynthetic process; IMP:CACAO. # GO_process GO:0006189 'de novo' IMP biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0006730 one-carbon metabolic process; TAS:EcoCyc. # GO_process GO:0009152 purine ribonucleotide biosynthetic process; IDA:EcoCyc. # GO_process GO:0009257 10-formyltetrahydrofolate biosynthetic process; TAS:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.170 -; 1. # HAMAP MF_01927 PurU # IntAct P37051 3 # InterPro IPR002376 Formyl_transf_N # InterPro IPR002912 ACT_dom # InterPro IPR004810 PurU # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00630 Glyoxylate and dicarboxylate metabolism # KEGG_Pathway ko00670 One carbon pool by folate # Organism PURU_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10520:SF7 PTHR10520:SF7 # PATHWAY PURU_ECOLI Purine metabolism; IMP biosynthesis via de novo pathway; formate from 10-formyl-5,6,7,8-tetrahydrofolate step 1/1. {ECO 0000255|HAMAP-Rule MF_01927, ECO 0000269|PubMed 7868604}. # PATRIC 32117720 VBIEscCol129921_1280 # PIR C36871 C36871 # PRINTS PR01575 FFH4HYDRLASE # PROSITE PS51671 ACT # Pfam PF00551 Formyl_trans_N # Pfam PF01842 ACT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Formyltetrahydrofolate deformylase {ECO:0000255|HAMAP-Rule MF_01927} # RefSeq NP_415748 NC_000913.3 # RefSeq WP_000555857 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA16860.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the PurU family. {ECO:0000255|HAMAP- Rule MF_01927}. # SIMILARITY Contains 1 ACT domain. {ECO:0000255|HAMAP- Rule MF_01927}. # SUBUNIT Homohexamer. {ECO:0000269|PubMed 7868604}. # SUPFAM SSF53328 SSF53328 # TIGRFAMs TIGR00655 PurU # UniPathway UPA00074 UER00170 # eggNOG COG0788 LUCA # eggNOG ENOG4105CIY Bacteria BLAST swissprot:PURU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PURU_ECOLI BioCyc ECOL316407:JW1220-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1220-MONOMER BioCyc EcoCyc:FORMYLTHFDEFORMYL-MONOMER http://biocyc.org/getid?id=EcoCyc:FORMYLTHFDEFORMYL-MONOMER BioCyc MetaCyc:FORMYLTHFDEFORMYL-MONOMER http://biocyc.org/getid?id=MetaCyc:FORMYLTHFDEFORMYL-MONOMER COG COG0788 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0788 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.5.1.10 {ECO:0000255|HAMAP-Rule:MF_01927} http://www.genome.jp/dbget-bin/www_bget?EC:3.5.1.10 {ECO:0000255|HAMAP-Rule:MF_01927} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L20251 http://www.ebi.ac.uk/ena/data/view/L20251 EMBL M64675 http://www.ebi.ac.uk/ena/data/view/M64675 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.5.1.10 {ECO:0000255|HAMAP-Rule:MF_01927} http://enzyme.expasy.org/EC/3.5.1.10 {ECO:0000255|HAMAP-Rule:MF_01927} EchoBASE EB1766 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1766 EcoGene EG11819 http://www.ecogene.org/geneInfo.php?eg_id=EG11819 EnsemblBacteria AAC74314 http://www.ensemblgenomes.org/id/AAC74314 EnsemblBacteria AAC74314 http://www.ensemblgenomes.org/id/AAC74314 EnsemblBacteria BAA36100 http://www.ensemblgenomes.org/id/BAA36100 EnsemblBacteria BAA36100 http://www.ensemblgenomes.org/id/BAA36100 EnsemblBacteria BAA36100 http://www.ensemblgenomes.org/id/BAA36100 EnsemblBacteria b1232 http://www.ensemblgenomes.org/id/b1232 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008864 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008864 GO_function GO:0016597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016597 GO_function GO:0016742 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016742 GO_process GO:0006164 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006164 GO_process GO:0006189 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006189 GO_process GO:0006730 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006730 GO_process GO:0009152 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009152 GO_process GO:0009257 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009257 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.170 http://www.cathdb.info/version/latest/superfamily/3.40.50.170 GeneID 945827 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945827 HAMAP MF_01927 http://hamap.expasy.org/unirule/MF_01927 HOGENOM HOG000033576 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000033576&db=HOGENOM6 InParanoid P37051 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37051 IntAct P37051 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37051* IntEnz 3.5.1.10 {ECO:0000255|HAMAP-Rule:MF_01927} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.1.10 {ECO:0000255|HAMAP-Rule:MF_01927} InterPro IPR002376 http://www.ebi.ac.uk/interpro/entry/IPR002376 InterPro IPR002912 http://www.ebi.ac.uk/interpro/entry/IPR002912 InterPro IPR004810 http://www.ebi.ac.uk/interpro/entry/IPR004810 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1220 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1220 KEGG_Gene eco:b1232 http://www.genome.jp/dbget-bin/www_bget?eco:b1232 KEGG_Orthology KO:K01433 http://www.genome.jp/dbget-bin/www_bget?KO:K01433 KEGG_Pathway ko00630 http://www.genome.jp/kegg-bin/show_pathway?ko00630 KEGG_Pathway ko00670 http://www.genome.jp/kegg-bin/show_pathway?ko00670 KEGG_Reaction rn:R00944 http://www.genome.jp/dbget-bin/www_bget?rn:R00944 OMA ILRTICP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ILRTICP PANTHER PTHR10520:SF7 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10520:SF7 PRINTS PR01575 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01575 PROSITE PS51671 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51671 PSORT swissprot:PURU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PURU_ECOLI PSORT-B swissprot:PURU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PURU_ECOLI PSORT2 swissprot:PURU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PURU_ECOLI Pfam PF00551 http://pfam.xfam.org/family/PF00551 Pfam PF01842 http://pfam.xfam.org/family/PF01842 Phobius swissprot:PURU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PURU_ECOLI PhylomeDB P37051 http://phylomedb.org/?seqid=P37051 ProteinModelPortal P37051 http://www.proteinmodelportal.org/query/uniprot/P37051 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7868604 http://www.ncbi.nlm.nih.gov/pubmed/7868604 PubMed 8226647 http://www.ncbi.nlm.nih.gov/pubmed/8226647 PubMed 8282700 http://www.ncbi.nlm.nih.gov/pubmed/8282700 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415748 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415748 RefSeq WP_000555857 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000555857 SMR P37051 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37051 STRING 511145.b1232 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1232&targetmode=cogs STRING COG0788 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0788&targetmode=cogs SUPFAM SSF53328 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53328 TIGRFAMs TIGR00655 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00655 UniProtKB PURU_ECOLI http://www.uniprot.org/uniprot/PURU_ECOLI UniProtKB-AC P37051 http://www.uniprot.org/uniprot/P37051 charge swissprot:PURU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PURU_ECOLI eggNOG COG0788 http://eggnogapi.embl.de/nog_data/html/tree/COG0788 eggNOG ENOG4105CIY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CIY epestfind swissprot:PURU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PURU_ECOLI garnier swissprot:PURU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PURU_ECOLI helixturnhelix swissprot:PURU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PURU_ECOLI hmoment swissprot:PURU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PURU_ECOLI iep swissprot:PURU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PURU_ECOLI inforesidue swissprot:PURU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PURU_ECOLI octanol swissprot:PURU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PURU_ECOLI pepcoil swissprot:PURU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PURU_ECOLI pepdigest swissprot:PURU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PURU_ECOLI pepinfo swissprot:PURU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PURU_ECOLI pepnet swissprot:PURU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PURU_ECOLI pepstats swissprot:PURU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PURU_ECOLI pepwheel swissprot:PURU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PURU_ECOLI pepwindow swissprot:PURU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PURU_ECOLI sigcleave swissprot:PURU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PURU_ECOLI ## Database ID URL or Descriptions # AltName EUTR_ECOLI Ethanolamine operon regulatory protein # EcoGene EG12190 eutR # FUNCTION EUTR_ECOLI Activates the transcription of the eut operon. Also positively regulates its own transcription. Probably binds ethanolamine and vitamin B12 as effectors (By similarity). {ECO 0000250}. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_function GO:0019172 glyoxalase III activity; IBA:GO_Central. # GO_function GO:0043565 sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; ISS:EcoCyc. # GO_process GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione; IBA:GO_Central. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.10.60 -; 1. # IntAct P36547 3 # InterPro IPR009057 Homeodomain-like # InterPro IPR018060 HTH_AraC # InterPro IPR018062 HTH_AraC-typ_CS # KEGG_Brite ko03000 Transcription factors # Organism EUTR_ECOLI Escherichia coli (strain K12) # PATRIC 32120259 VBIEscCol129921_2532 # PIR D65018 D65018 # PROSITE PS00041 HTH_ARAC_FAMILY_1 # PROSITE PS01124 HTH_ARAC_FAMILY_2 # Pfam PF12833 HTH_18 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EUTR_ECOLI HTH-type transcriptional regulator eutR # RefSeq NP_416932 NC_000913.3 # RefSeq WP_000753690 NZ_LN832404.1 # SIMILARITY Contains 1 HTH araC/xylS-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00593}. # SMART SM00342 HTH_ARAC # SUPFAM SSF46689 SSF46689 # eggNOG ENOG4108K3Z Bacteria # eggNOG ENOG410ZX7Q LUCA BLAST swissprot:EUTR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EUTR_ECOLI BioCyc ECOL316407:JW2430-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2430-MONOMER BioCyc EcoCyc:EG12190-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12190-MONOMER COG COG2207 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2207 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X75413 http://www.ebi.ac.uk/ena/data/view/X75413 EchoBASE EB2107 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2107 EcoGene EG12190 http://www.ecogene.org/geneInfo.php?eg_id=EG12190 EnsemblBacteria AAC75490 http://www.ensemblgenomes.org/id/AAC75490 EnsemblBacteria AAC75490 http://www.ensemblgenomes.org/id/AAC75490 EnsemblBacteria BAA16320 http://www.ensemblgenomes.org/id/BAA16320 EnsemblBacteria BAA16320 http://www.ensemblgenomes.org/id/BAA16320 EnsemblBacteria BAA16320 http://www.ensemblgenomes.org/id/BAA16320 EnsemblBacteria b2437 http://www.ensemblgenomes.org/id/b2437 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0019172 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019172 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0019243 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019243 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 GeneID 946911 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946911 HOGENOM HOG000117033 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117033&db=HOGENOM6 IntAct P36547 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P36547* InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR018060 http://www.ebi.ac.uk/interpro/entry/IPR018060 InterPro IPR018062 http://www.ebi.ac.uk/interpro/entry/IPR018062 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW2430 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2430 KEGG_Gene eco:b2437 http://www.genome.jp/dbget-bin/www_bget?eco:b2437 KEGG_Orthology KO:K04033 http://www.genome.jp/dbget-bin/www_bget?KO:K04033 OMA FLHHPER http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FLHHPER PROSITE PS00041 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00041 PROSITE PS01124 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01124 PSORT swissprot:EUTR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EUTR_ECOLI PSORT-B swissprot:EUTR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EUTR_ECOLI PSORT2 swissprot:EUTR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EUTR_ECOLI Pfam PF12833 http://pfam.xfam.org/family/PF12833 Phobius swissprot:EUTR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EUTR_ECOLI PhylomeDB P36547 http://phylomedb.org/?seqid=P36547 ProteinModelPortal P36547 http://www.proteinmodelportal.org/query/uniprot/P36547 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8300522 http://www.ncbi.nlm.nih.gov/pubmed/8300522 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416932 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416932 RefSeq WP_000753690 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000753690 SMART SM00342 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00342 SMR P36547 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P36547 STRING 511145.b2437 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2437&targetmode=cogs STRING COG2207 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2207&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 UniProtKB EUTR_ECOLI http://www.uniprot.org/uniprot/EUTR_ECOLI UniProtKB-AC P36547 http://www.uniprot.org/uniprot/P36547 charge swissprot:EUTR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EUTR_ECOLI eggNOG ENOG4108K3Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108K3Z eggNOG ENOG410ZX7Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZX7Q epestfind swissprot:EUTR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EUTR_ECOLI garnier swissprot:EUTR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EUTR_ECOLI helixturnhelix swissprot:EUTR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EUTR_ECOLI hmoment swissprot:EUTR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EUTR_ECOLI iep swissprot:EUTR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EUTR_ECOLI inforesidue swissprot:EUTR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EUTR_ECOLI octanol swissprot:EUTR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EUTR_ECOLI pepcoil swissprot:EUTR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EUTR_ECOLI pepdigest swissprot:EUTR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EUTR_ECOLI pepinfo swissprot:EUTR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EUTR_ECOLI pepnet swissprot:EUTR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EUTR_ECOLI pepstats swissprot:EUTR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EUTR_ECOLI pepwheel swissprot:EUTR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EUTR_ECOLI pepwindow swissprot:EUTR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EUTR_ECOLI sigcleave swissprot:EUTR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EUTR_ECOLI ## Database ID URL or Descriptions # BioGrid 4261472 10 # CDD cd06174 MFS # EcoGene EG11689 yicM # FUNCTION NEPI_ECOLI Involved in the efflux of purine ribonucleosides, such as guanosine, adenosine and especially inosine. Involved in the resistance to 6-mercaptopurine. {ECO 0000269|PubMed 16040204}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015211 purine nucleoside transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0015860 purine nucleoside transmembrane transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0055085 transmembrane transport # HAMAP MF_01189 MFS_NepI # INDUCTION In stationary phase. {ECO:0000269|PubMed 16040204}. # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # InterPro IPR023680 MFS_NepI # KEGG_Brite ko02000 Transporters # Organism NEPI_ECOLI Escherichia coli (strain K12) # PATRIC 32122817 VBIEscCol129921_3784 # PIR G65167 G65167 # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NEPI_ECOLI Purine ribonucleoside efflux pump NepI # RefSeq NP_418118 NC_000913.3 # RefSeq WP_001288549 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA62014.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAW51767.1; Type=Frameshift; Positions=367; Evidence={ECO 0000305}; Sequence=BAE77631.1; Type=Erroneous initiation; Evidence={ECO:0000305}; # SIMILARITY Belongs to the major facilitator superfamily. DHA1 family. NepI (TC 2.A.1.2.26) subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION NEPI_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.2.26 the major facilitator superfamily (mfs) # eggNOG COG2814 LUCA # eggNOG ENOG4107RTG Bacteria BLAST swissprot:NEPI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NEPI_ECOLI BioCyc ECOL316407:JW5938-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5938-MONOMER BioCyc EcoCyc:YICM-MONOMER http://biocyc.org/getid?id=EcoCyc:YICM-MONOMER BioCyc MetaCyc:YICM-MONOMER http://biocyc.org/getid?id=MetaCyc:YICM-MONOMER COG COG2814 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2814 DIP DIP-48180N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48180N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1016/j.femsle.2005.06.051 http://dx.doi.org/10.1016/j.femsle.2005.06.051 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.188.3.977-987.2006 http://dx.doi.org/10.1128/JB.188.3.977-987.2006 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL AY857617 http://www.ebi.ac.uk/ena/data/view/AY857617 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1640 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1640 EcoGene EG11689 http://www.ecogene.org/geneInfo.php?eg_id=EG11689 EnsemblBacteria AAC76685 http://www.ensemblgenomes.org/id/AAC76685 EnsemblBacteria AAC76685 http://www.ensemblgenomes.org/id/AAC76685 EnsemblBacteria BAE77631 http://www.ensemblgenomes.org/id/BAE77631 EnsemblBacteria BAE77631 http://www.ensemblgenomes.org/id/BAE77631 EnsemblBacteria BAE77631 http://www.ensemblgenomes.org/id/BAE77631 EnsemblBacteria b3662 http://www.ensemblgenomes.org/id/b3662 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015211 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015211 GO_process GO:0015860 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015860 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 948213 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948213 HAMAP MF_01189 http://hamap.expasy.org/unirule/MF_01189 HOGENOM HOG000136928 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000136928&db=HOGENOM6 InParanoid P0ADL1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADL1 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 InterPro IPR023680 http://www.ebi.ac.uk/interpro/entry/IPR023680 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5938 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5938 KEGG_Gene eco:b3662 http://www.genome.jp/dbget-bin/www_bget?eco:b3662 KEGG_Orthology KO:K03445 http://www.genome.jp/dbget-bin/www_bget?KO:K03445 OMA WTMATAT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WTMATAT PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:NEPI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NEPI_ECOLI PSORT-B swissprot:NEPI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NEPI_ECOLI PSORT2 swissprot:NEPI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NEPI_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:NEPI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NEPI_ECOLI PhylomeDB P0ADL1 http://phylomedb.org/?seqid=P0ADL1 ProteinModelPortal P0ADL1 http://www.proteinmodelportal.org/query/uniprot/P0ADL1 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16040204 http://www.ncbi.nlm.nih.gov/pubmed/16040204 PubMed 16428402 http://www.ncbi.nlm.nih.gov/pubmed/16428402 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418118 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418118 RefSeq WP_001288549 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001288549 STRING 511145.b3662 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3662&targetmode=cogs STRING COG2814 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2814&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.2.26 http://www.tcdb.org/search/result.php?tc=2.A.1.2.26 UniProtKB NEPI_ECOLI http://www.uniprot.org/uniprot/NEPI_ECOLI UniProtKB-AC P0ADL1 http://www.uniprot.org/uniprot/P0ADL1 charge swissprot:NEPI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NEPI_ECOLI eggNOG COG2814 http://eggnogapi.embl.de/nog_data/html/tree/COG2814 eggNOG ENOG4107RTG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107RTG epestfind swissprot:NEPI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NEPI_ECOLI garnier swissprot:NEPI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NEPI_ECOLI helixturnhelix swissprot:NEPI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NEPI_ECOLI hmoment swissprot:NEPI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NEPI_ECOLI iep swissprot:NEPI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NEPI_ECOLI inforesidue swissprot:NEPI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NEPI_ECOLI octanol swissprot:NEPI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NEPI_ECOLI pepcoil swissprot:NEPI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NEPI_ECOLI pepdigest swissprot:NEPI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NEPI_ECOLI pepinfo swissprot:NEPI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NEPI_ECOLI pepnet swissprot:NEPI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NEPI_ECOLI pepstats swissprot:NEPI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NEPI_ECOLI pepwheel swissprot:NEPI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NEPI_ECOLI pepwindow swissprot:NEPI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NEPI_ECOLI sigcleave swissprot:NEPI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NEPI_ECOLI ## Database ID URL or Descriptions # BioGrid 4259572 15 # CATALYTIC ACTIVITY Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. {ECO:0000255|HAMAP- Rule MF_01208}. # CDD cd06223 PRTases_typeI # COFACTOR PYRE_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_01208}; # ENZYME REGULATION Inhibited by sulfate and phosphate ions. {ECO:0000269|PubMed 8620002}. # EcoGene EG10808 pyrE # FUNCTION PYRE_ECOLI Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). {ECO 0000255|HAMAP- Rule MF_01208, ECO 0000269|PubMed 8620002}. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0004588 orotate phosphoribosyltransferase activity; IDA:EcoCyc. # GO_process GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process; IMP:EcoCyc. # GO_process GO:0006221 pyrimidine nucleotide biosynthetic process; IMP:EcoliWiki. # GO_process GO:0044205 'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.2020 -; 1. # HAMAP MF_01208 PyrE # InterPro IPR000836 PRibTrfase_dom # InterPro IPR004467 Or_phspho_trans_dom # InterPro IPR023031 OPRT # InterPro IPR029057 PRTase-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00240 Pyrimidine metabolism # Organism PYRE_ECOLI Escherichia coli (strain K12) # PATHWAY Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. {ECO 0000255|HAMAP- Rule:MF_01208}. # PATRIC 32122771 VBIEscCol129921_3762 # PDB 1ORO X-ray; 2.40 A; A/B=1-213 # PIR D65165 XJEC # PROSITE PS00103 PUR_PYR_PR_TRANSFER # Pfam PF00156 Pribosyltran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Orotate phosphoribosyltransferase {ECO:0000255|HAMAP-Rule MF_01208} # RefSeq NP_418099 NC_000913.3 # RefSeq WP_000806177 NZ_LN832404.1 # SIMILARITY Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily. {ECO:0000255|HAMAP-Rule MF_01208}. # SUBUNIT PYRE_ECOLI Homodimer. {ECO 0000269|PubMed 6349999, ECO 0000269|PubMed 8620002}. # SUPFAM SSF53271 SSF53271 # TIGRFAMs TIGR00336 pyrE # UniPathway UPA00070 UER00119 # eggNOG COG0461 LUCA # eggNOG ENOG4107QP2 Bacteria BLAST swissprot:PYRE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PYRE_ECOLI BioCyc ECOL316407:JW3617-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3617-MONOMER BioCyc EcoCyc:OROPRIBTRANS-MONOMER http://biocyc.org/getid?id=EcoCyc:OROPRIBTRANS-MONOMER BioCyc MetaCyc:OROPRIBTRANS-MONOMER http://biocyc.org/getid?id=MetaCyc:OROPRIBTRANS-MONOMER COG COG0461 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0461 DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1021/bi952226y http://dx.doi.org/10.1021/bi952226y DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1432-1033.1983.tb07641.x http://dx.doi.org/10.1111/j.1432-1033.1983.tb07641.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.4.2.10 {ECO:0000255|HAMAP-Rule:MF_01208} http://www.genome.jp/dbget-bin/www_bget?EC:2.4.2.10 {ECO:0000255|HAMAP-Rule:MF_01208} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V01578 http://www.ebi.ac.uk/ena/data/view/V01578 EMBL X00781 http://www.ebi.ac.uk/ena/data/view/X00781 ENZYME 2.4.2.10 {ECO:0000255|HAMAP-Rule:MF_01208} http://enzyme.expasy.org/EC/2.4.2.10 {ECO:0000255|HAMAP-Rule:MF_01208} EchoBASE EB0801 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0801 EcoGene EG10808 http://www.ecogene.org/geneInfo.php?eg_id=EG10808 EnsemblBacteria AAC76666 http://www.ensemblgenomes.org/id/AAC76666 EnsemblBacteria AAC76666 http://www.ensemblgenomes.org/id/AAC76666 EnsemblBacteria BAE77650 http://www.ensemblgenomes.org/id/BAE77650 EnsemblBacteria BAE77650 http://www.ensemblgenomes.org/id/BAE77650 EnsemblBacteria BAE77650 http://www.ensemblgenomes.org/id/BAE77650 EnsemblBacteria b3642 http://www.ensemblgenomes.org/id/b3642 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0004588 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004588 GO_process GO:0006207 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006207 GO_process GO:0006221 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006221 GO_process GO:0044205 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044205 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.2020 http://www.cathdb.info/version/latest/superfamily/3.40.50.2020 GeneID 948157 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948157 HAMAP MF_01208 http://hamap.expasy.org/unirule/MF_01208 HOGENOM HOG000037974 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000037974&db=HOGENOM6 InParanoid P0A7E3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7E3 IntAct P0A7E3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7E3* IntEnz 2.4.2.10 {ECO:0000255|HAMAP-Rule:MF_01208} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.2.10 {ECO:0000255|HAMAP-Rule:MF_01208} InterPro IPR000836 http://www.ebi.ac.uk/interpro/entry/IPR000836 InterPro IPR004467 http://www.ebi.ac.uk/interpro/entry/IPR004467 InterPro IPR023031 http://www.ebi.ac.uk/interpro/entry/IPR023031 InterPro IPR029057 http://www.ebi.ac.uk/interpro/entry/IPR029057 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3617 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3617 KEGG_Gene eco:b3642 http://www.genome.jp/dbget-bin/www_bget?eco:b3642 KEGG_Orthology KO:K00762 http://www.genome.jp/dbget-bin/www_bget?KO:K00762 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Reaction rn:R01870 http://www.genome.jp/dbget-bin/www_bget?rn:R01870 OMA MKAYQRQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MKAYQRQ PDB 1ORO http://www.ebi.ac.uk/pdbe-srv/view/entry/1ORO PDBsum 1ORO http://www.ebi.ac.uk/pdbsum/1ORO PROSITE PS00103 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00103 PSORT swissprot:PYRE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PYRE_ECOLI PSORT-B swissprot:PYRE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PYRE_ECOLI PSORT2 swissprot:PYRE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PYRE_ECOLI Pfam PF00156 http://pfam.xfam.org/family/PF00156 Phobius swissprot:PYRE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PYRE_ECOLI PhylomeDB P0A7E3 http://phylomedb.org/?seqid=P0A7E3 ProteinModelPortal P0A7E3 http://www.proteinmodelportal.org/query/uniprot/P0A7E3 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6207018 http://www.ncbi.nlm.nih.gov/pubmed/6207018 PubMed 6349999 http://www.ncbi.nlm.nih.gov/pubmed/6349999 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 8620002 http://www.ncbi.nlm.nih.gov/pubmed/8620002 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_418099 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418099 RefSeq WP_000806177 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000806177 SMR P0A7E3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7E3 STRING 511145.b3642 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3642&targetmode=cogs STRING COG0461 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0461&targetmode=cogs SUPFAM SSF53271 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53271 TIGRFAMs TIGR00336 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00336 UniProtKB PYRE_ECOLI http://www.uniprot.org/uniprot/PYRE_ECOLI UniProtKB-AC P0A7E3 http://www.uniprot.org/uniprot/P0A7E3 charge swissprot:PYRE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PYRE_ECOLI eggNOG COG0461 http://eggnogapi.embl.de/nog_data/html/tree/COG0461 eggNOG ENOG4107QP2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QP2 epestfind swissprot:PYRE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PYRE_ECOLI garnier swissprot:PYRE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PYRE_ECOLI helixturnhelix swissprot:PYRE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PYRE_ECOLI hmoment swissprot:PYRE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PYRE_ECOLI iep swissprot:PYRE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PYRE_ECOLI inforesidue swissprot:PYRE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PYRE_ECOLI octanol swissprot:PYRE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PYRE_ECOLI pepcoil swissprot:PYRE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PYRE_ECOLI pepdigest swissprot:PYRE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PYRE_ECOLI pepinfo swissprot:PYRE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PYRE_ECOLI pepnet swissprot:PYRE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PYRE_ECOLI pepstats swissprot:PYRE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PYRE_ECOLI pepwheel swissprot:PYRE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PYRE_ECOLI pepwindow swissprot:PYRE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PYRE_ECOLI sigcleave swissprot:PYRE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PYRE_ECOLI ## Database ID URL or Descriptions # BioGrid 4259931 185 # EcoGene EG13306 ybgJ # Gene3D 2.40.100.10 -; 1. # Gene3D 3.30.1360.40 -; 1. # IntAct P0AAV4 4 # InterPro IPR003833 CT_C_D # InterPro IPR010016 KipI_fam # InterPro IPR024946 Arg_repress_C-like # InterPro IPR029000 Cyclophilin-like_dom # Organism YBGJ_ECOLI Escherichia coli (strain K12) # PATRIC 32116617 VBIEscCol129921_0741 # PDB 5DUD X-ray; 2.80 A; B/D=1-218 # PIR F64806 F64806 # Pfam PF02682 CT_C_D # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBGJ_ECOLI Uncharacterized protein YbgJ # RefSeq NP_415239 NC_000913.3 # RefSeq WP_001188343 NZ_LN832404.1 # SIMILARITY To B.subtilis YcsJ and yeast urea amidolyase (DUR1,2). {ECO 0000305}. # SIMILARITY To H.influenzae HI_1731. {ECO 0000305}. # SMART SM00796 AHS1 # SUPFAM SSF50891 SSF50891 # TIGRFAMs TIGR00370 TIGR00370 # eggNOG COG2049 LUCA # eggNOG ENOG4105P4J Bacteria BLAST swissprot:YBGJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBGJ_ECOLI BioCyc ECOL316407:JW0701-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0701-MONOMER BioCyc EcoCyc:G6380-MONOMER http://biocyc.org/getid?id=EcoCyc:G6380-MONOMER DIP DIP-48145N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48145N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3090 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3090 EcoGene EG13306 http://www.ecogene.org/geneInfo.php?eg_id=EG13306 EnsemblBacteria AAC73805 http://www.ensemblgenomes.org/id/AAC73805 EnsemblBacteria AAC73805 http://www.ensemblgenomes.org/id/AAC73805 EnsemblBacteria BAA35375 http://www.ensemblgenomes.org/id/BAA35375 EnsemblBacteria BAA35375 http://www.ensemblgenomes.org/id/BAA35375 EnsemblBacteria BAA35375 http://www.ensemblgenomes.org/id/BAA35375 EnsemblBacteria b0711 http://www.ensemblgenomes.org/id/b0711 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 2.40.100.10 http://www.cathdb.info/version/latest/superfamily/2.40.100.10 Gene3D 3.30.1360.40 http://www.cathdb.info/version/latest/superfamily/3.30.1360.40 GeneID 945311 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945311 HOGENOM HOG000265714 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000265714&db=HOGENOM6 InParanoid P0AAV4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAV4 IntAct P0AAV4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAV4* InterPro IPR003833 http://www.ebi.ac.uk/interpro/entry/IPR003833 InterPro IPR010016 http://www.ebi.ac.uk/interpro/entry/IPR010016 InterPro IPR024946 http://www.ebi.ac.uk/interpro/entry/IPR024946 InterPro IPR029000 http://www.ebi.ac.uk/interpro/entry/IPR029000 KEGG_Gene ecj:JW0701 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0701 KEGG_Gene eco:b0711 http://www.genome.jp/dbget-bin/www_bget?eco:b0711 MINT MINT-1316053 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1316053 OMA QPGFAYM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QPGFAYM PDB 5DUD http://www.ebi.ac.uk/pdbe-srv/view/entry/5DUD PDBsum 5DUD http://www.ebi.ac.uk/pdbsum/5DUD PSORT swissprot:YBGJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBGJ_ECOLI PSORT-B swissprot:YBGJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBGJ_ECOLI PSORT2 swissprot:YBGJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBGJ_ECOLI Pfam PF02682 http://pfam.xfam.org/family/PF02682 Phobius swissprot:YBGJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBGJ_ECOLI PhylomeDB P0AAV4 http://phylomedb.org/?seqid=P0AAV4 ProteinModelPortal P0AAV4 http://www.proteinmodelportal.org/query/uniprot/P0AAV4 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415239 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415239 RefSeq WP_001188343 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001188343 SMART SM00796 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00796 SMR P0AAV4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAV4 STRING 511145.b0711 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0711&targetmode=cogs SUPFAM SSF50891 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50891 TIGRFAMs TIGR00370 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00370 UniProtKB YBGJ_ECOLI http://www.uniprot.org/uniprot/YBGJ_ECOLI UniProtKB-AC P0AAV4 http://www.uniprot.org/uniprot/P0AAV4 charge swissprot:YBGJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBGJ_ECOLI eggNOG COG2049 http://eggnogapi.embl.de/nog_data/html/tree/COG2049 eggNOG ENOG4105P4J http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105P4J epestfind swissprot:YBGJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBGJ_ECOLI garnier swissprot:YBGJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBGJ_ECOLI helixturnhelix swissprot:YBGJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBGJ_ECOLI hmoment swissprot:YBGJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBGJ_ECOLI iep swissprot:YBGJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBGJ_ECOLI inforesidue swissprot:YBGJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBGJ_ECOLI octanol swissprot:YBGJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBGJ_ECOLI pepcoil swissprot:YBGJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBGJ_ECOLI pepdigest swissprot:YBGJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBGJ_ECOLI pepinfo swissprot:YBGJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBGJ_ECOLI pepnet swissprot:YBGJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBGJ_ECOLI pepstats swissprot:YBGJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBGJ_ECOLI pepwheel swissprot:YBGJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBGJ_ECOLI pepwindow swissprot:YBGJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBGJ_ECOLI sigcleave swissprot:YBGJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBGJ_ECOLI ## Database ID URL or Descriptions # AltName NAC_ECOLI Nitrogen assimilation control protein # BioGrid 4260407 8 # EcoGene EG14265 nac # FUNCTION NAC_ECOLI Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation. Negative regulator of its own expression (By similarity). {ECO 0000250}. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0042128 nitrate assimilation; IEA:UniProtKB-KW. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0071941 nitrogen cycle metabolic process # Gene3D 1.10.10.10 -; 1. # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR005119 LysR_subst-bd # InterPro IPR011991 WHTH_DNA-bd_dom # Organism NAC_ECOLI Escherichia coli (strain K12) # PATRIC 32119307 VBIEscCol129921_2064 # PIR D64963 D64963 # PRINTS PR00039 HTHLYSR # PROSITE PS50931 HTH_LYSR # Pfam PF00126 HTH_1 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NAC_ECOLI Nitrogen assimilation regulatory protein nac # RefSeq NP_416493 NC_000913.3 # RefSeq WP_001011462 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lysR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00253}. # SUPFAM SSF46785 SSF46785 # eggNOG ENOG4106P55 Bacteria # eggNOG ENOG410YGJ0 LUCA BLAST swissprot:NAC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NAC_ECOLI BioCyc ECOL316407:JW1967-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1967-MONOMER BioCyc EcoCyc:G7072-MONOMER http://biocyc.org/getid?id=EcoCyc:G7072-MONOMER DOI 10.1016/0378-1119(95)00606-8 http://dx.doi.org/10.1016/0378-1119(95)00606-8 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L31639 http://www.ebi.ac.uk/ena/data/view/L31639 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U56736 http://www.ebi.ac.uk/ena/data/view/U56736 EchoBASE EB4013 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4013 EcoGene EG14265 http://www.ecogene.org/geneInfo.php?eg_id=EG14265 EnsemblBacteria AAC75050 http://www.ensemblgenomes.org/id/AAC75050 EnsemblBacteria AAC75050 http://www.ensemblgenomes.org/id/AAC75050 EnsemblBacteria BAA15806 http://www.ensemblgenomes.org/id/BAA15806 EnsemblBacteria BAA15806 http://www.ensemblgenomes.org/id/BAA15806 EnsemblBacteria BAA15806 http://www.ensemblgenomes.org/id/BAA15806 EnsemblBacteria b1988 http://www.ensemblgenomes.org/id/b1988 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0042128 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042128 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0071941 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071941 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 946501 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946501 HOGENOM HOG000233514 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000233514&db=HOGENOM6 InParanoid Q47005 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q47005 IntAct Q47005 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q47005* InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW1967 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1967 KEGG_Gene eco:b1988 http://www.genome.jp/dbget-bin/www_bget?eco:b1988 OMA YRHAQII http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YRHAQII PRINTS PR00039 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00039 PROSITE PS50931 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50931 PSORT swissprot:NAC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NAC_ECOLI PSORT-B swissprot:NAC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NAC_ECOLI PSORT2 swissprot:NAC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NAC_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:NAC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NAC_ECOLI PhylomeDB Q47005 http://phylomedb.org/?seqid=Q47005 ProteinModelPortal Q47005 http://www.proteinmodelportal.org/query/uniprot/Q47005 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8529872 http://www.ncbi.nlm.nih.gov/pubmed/8529872 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9495755 http://www.ncbi.nlm.nih.gov/pubmed/9495755 RefSeq NP_416493 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416493 RefSeq WP_001011462 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001011462 SMR Q47005 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q47005 STRING 511145.b1988 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1988&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB NAC_ECOLI http://www.uniprot.org/uniprot/NAC_ECOLI UniProtKB-AC Q47005 http://www.uniprot.org/uniprot/Q47005 charge swissprot:NAC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NAC_ECOLI eggNOG ENOG4106P55 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106P55 eggNOG ENOG410YGJ0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YGJ0 epestfind swissprot:NAC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NAC_ECOLI garnier swissprot:NAC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NAC_ECOLI helixturnhelix swissprot:NAC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NAC_ECOLI hmoment swissprot:NAC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NAC_ECOLI iep swissprot:NAC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NAC_ECOLI inforesidue swissprot:NAC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NAC_ECOLI octanol swissprot:NAC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NAC_ECOLI pepcoil swissprot:NAC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NAC_ECOLI pepdigest swissprot:NAC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NAC_ECOLI pepinfo swissprot:NAC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NAC_ECOLI pepnet swissprot:NAC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NAC_ECOLI pepstats swissprot:NAC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NAC_ECOLI pepwheel swissprot:NAC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NAC_ECOLI pepwindow swissprot:NAC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NAC_ECOLI sigcleave swissprot:NAC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NAC_ECOLI ## Database ID URL or Descriptions # AltName GABT_ECOLI (S)-3-amino-2-methylpropionate transaminase # AltName GABT_ECOLI GABA aminotransferase # AltName GABT_ECOLI Gamma-amino-N-butyrate transaminase # AltName GABT_ECOLI L-AIBAT # AltName Glutamate succinic semialdehyde transaminase # BRENDA 2.6.1.19 2026 # BioGrid 4259210 8 # CATALYTIC ACTIVITY GABT_ECOLI (S)-3-amino-2-methylpropanoate + 2- oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate. # CATALYTIC ACTIVITY GABT_ECOLI 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate. # CDD cd00610 OAT_like # COFACTOR GABT_ECOLI Name=pyridoxal 5'-phosphate; Xref=ChEBI CHEBI 597326; Evidence={ECO 0000269|PubMed 15723541}; # DISRUPTION PHENOTYPE GABT_ECOLI Cells show only 68% of the wild-type activity and are not able to utilize GABA as a nitrogen source. {ECO 0000269|PubMed 12446648, ECO 0000269|PubMed 20639325}. # EcoGene EG10361 gabT # FUNCTION GABT_ECOLI Catalyzes the transfer of the amino group from gamma- aminobutyrate (GABA) to alpha-ketoglutarate (KG) to yield succinic semialdehyde (SSA). {ECO 0000269|PubMed 20639325}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GABT_ECOLI GO 0003992 N2-acetyl-L-ornithine 2-oxoglutarate 5-aminotransferase activity; IDA EcoCyc. # GO_function GO:0003867 4-aminobutyrate transaminase activity; IDA:EcoCyc. # GO_function GO:0030170 pyridoxal phosphate binding; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IBA:GO_Central. # GO_function GO:0047298 (S)-3-amino-2-methylpropionate transaminase activity; IEA:UniProtKB-EC. # GO_process GO:0009450 gamma-aminobutyric acid catabolic process; IMP:EcoCyc. # GO_process GO:0042450 arginine biosynthetic process via ornithine; IGI:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.640.10 -; 1. # Gene3D 3.90.1150.10 -; 1. # INDUCTION Induced by RpoS in response to multiple stress conditions, including shifts to acidic pH or high osmolarity as well as starvation or stationary phase. Catabolite repression by glucose (repression relieved by GABA). {ECO:0000269|PubMed 14731280}. # IntAct P22256 12 # InterPro IPR004632 4NH2But_aminotransferase_bac # InterPro IPR005814 Aminotrans_3 # InterPro IPR015421 PyrdxlP-dep_Trfase_major_sub1 # InterPro IPR015422 PyrdxlP-dep_Trfase_major_sub2 # InterPro IPR015424 PyrdxlP-dep_Trfase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01007 Amino acid related enzymes # KEGG_Pathway ko00250 Alanine, aspartate and glutamate metabolism # KEGG_Pathway ko00280 Valine, leucine and isoleucine degradation # KEGG_Pathway ko00410 beta-Alanine metabolism # KEGG_Pathway ko00640 Propanoate metabolism # KEGG_Pathway ko00650 Butanoate metabolism # Organism GABT_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11986 PTHR11986 # PATHWAY GABT_ECOLI Amino-acid degradation; 4-aminobutanoate degradation. # PATRIC 32120714 VBIEscCol129921_2754 # PDB 1SF2 X-ray; 2.40 A; A/B/C/D=1-426 # PDB 1SFF X-ray; 1.90 A; A/B/C/D=1-426 # PDB 1SZK X-ray; 2.52 A; A/B/C/D=1-426 # PDB 1SZS X-ray; 2.10 A; A/B/C/D=1-426 # PDB 1SZU X-ray; 2.52 A; A/B/C/D=1-426 # PIR A37846 A37846 # PROSITE PS00600 AA_TRANSFER_CLASS_3 # Pfam PF00202 Aminotran_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GABT_ECOLI 4-aminobutyrate aminotransferase GabT # RefSeq NP_417148 NC_000913.3 # RefSeq WP_001087611 NZ_LN832404.1 # SIMILARITY Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. {ECO 0000305}. # SUBUNIT GABT_ECOLI Homotetramer. {ECO 0000269|PubMed 15323550, ECO 0000269|PubMed 15723541}. # SUPFAM SSF53383 SSF53383 # TIGRFAMs TIGR00700 GABAtrnsam # eggNOG COG0160 LUCA # eggNOG ENOG4108JPW Bacteria BLAST swissprot:GABT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GABT_ECOLI BioCyc ECOL316407:JW2637-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2637-MONOMER BioCyc EcoCyc:GABATRANSAM-MONOMER http://biocyc.org/getid?id=EcoCyc:GABATRANSAM-MONOMER BioCyc MetaCyc:GABATRANSAM-MONOMER http://biocyc.org/getid?id=MetaCyc:GABATRANSAM-MONOMER COG COG0160 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0160 DIP DIP-9725N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9725N DOI 10.1021/bi048657a http://dx.doi.org/10.1021/bi048657a DOI 10.1021/bi049218e http://dx.doi.org/10.1021/bi049218e DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2003.03867.x http://dx.doi.org/10.1046/j.1365-2958.2003.03867.x DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00308-10 http://dx.doi.org/10.1128/JB.00308-10 DOI 10.1128/JB.184.24.6976-6986.2002 http://dx.doi.org/10.1128/JB.184.24.6976-6986.2002 EC_number EC:2.6.1.19 http://www.genome.jp/dbget-bin/www_bget?EC:2.6.1.19 EC_number EC:2.6.1.22 http://www.genome.jp/dbget-bin/www_bget?EC:2.6.1.22 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M88334 http://www.ebi.ac.uk/ena/data/view/M88334 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.6.1.19 http://enzyme.expasy.org/EC/2.6.1.19 ENZYME 2.6.1.22 http://enzyme.expasy.org/EC/2.6.1.22 EchoBASE EB0356 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0356 EcoGene EG10361 http://www.ecogene.org/geneInfo.php?eg_id=EG10361 EnsemblBacteria AAC75709 http://www.ensemblgenomes.org/id/AAC75709 EnsemblBacteria AAC75709 http://www.ensemblgenomes.org/id/AAC75709 EnsemblBacteria BAA16525 http://www.ensemblgenomes.org/id/BAA16525 EnsemblBacteria BAA16525 http://www.ensemblgenomes.org/id/BAA16525 EnsemblBacteria BAA16525 http://www.ensemblgenomes.org/id/BAA16525 EnsemblBacteria b2662 http://www.ensemblgenomes.org/id/b2662 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003867 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003867 GO_function GO:0003992 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003992 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0047298 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047298 GO_process GO:0009450 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009450 GO_process GO:0042450 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042450 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.640.10 http://www.cathdb.info/version/latest/superfamily/3.40.640.10 Gene3D 3.90.1150.10 http://www.cathdb.info/version/latest/superfamily/3.90.1150.10 GeneID 948067 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948067 HOGENOM HOG000020206 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000020206&db=HOGENOM6 InParanoid P22256 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P22256 IntAct P22256 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P22256* IntEnz 2.6.1.19 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.6.1.19 IntEnz 2.6.1.22 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.6.1.22 InterPro IPR004632 http://www.ebi.ac.uk/interpro/entry/IPR004632 InterPro IPR005814 http://www.ebi.ac.uk/interpro/entry/IPR005814 InterPro IPR015421 http://www.ebi.ac.uk/interpro/entry/IPR015421 InterPro IPR015422 http://www.ebi.ac.uk/interpro/entry/IPR015422 InterPro IPR015424 http://www.ebi.ac.uk/interpro/entry/IPR015424 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Gene ecj:JW2637 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2637 KEGG_Gene eco:b2662 http://www.genome.jp/dbget-bin/www_bget?eco:b2662 KEGG_Orthology KO:K07250 http://www.genome.jp/dbget-bin/www_bget?KO:K07250 KEGG_Pathway ko00250 http://www.genome.jp/kegg-bin/show_pathway?ko00250 KEGG_Pathway ko00280 http://www.genome.jp/kegg-bin/show_pathway?ko00280 KEGG_Pathway ko00410 http://www.genome.jp/kegg-bin/show_pathway?ko00410 KEGG_Pathway ko00640 http://www.genome.jp/kegg-bin/show_pathway?ko00640 KEGG_Pathway ko00650 http://www.genome.jp/kegg-bin/show_pathway?ko00650 KEGG_Reaction rn:R00908 http://www.genome.jp/dbget-bin/www_bget?rn:R00908 KEGG_Reaction rn:R01648 http://www.genome.jp/dbget-bin/www_bget?rn:R01648 KEGG_Reaction rn:R04188 http://www.genome.jp/dbget-bin/www_bget?rn:R04188 MINT MINT-1274800 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1274800 OMA DIFEEEH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DIFEEEH PANTHER PTHR11986 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11986 PDB 1SF2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1SF2 PDB 1SFF http://www.ebi.ac.uk/pdbe-srv/view/entry/1SFF PDB 1SZK http://www.ebi.ac.uk/pdbe-srv/view/entry/1SZK PDB 1SZS http://www.ebi.ac.uk/pdbe-srv/view/entry/1SZS PDB 1SZU http://www.ebi.ac.uk/pdbe-srv/view/entry/1SZU PDBsum 1SF2 http://www.ebi.ac.uk/pdbsum/1SF2 PDBsum 1SFF http://www.ebi.ac.uk/pdbsum/1SFF PDBsum 1SZK http://www.ebi.ac.uk/pdbsum/1SZK PDBsum 1SZS http://www.ebi.ac.uk/pdbsum/1SZS PDBsum 1SZU http://www.ebi.ac.uk/pdbsum/1SZU PROSITE PS00600 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00600 PSORT swissprot:GABT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GABT_ECOLI PSORT-B swissprot:GABT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GABT_ECOLI PSORT2 swissprot:GABT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GABT_ECOLI Pfam PF00202 http://pfam.xfam.org/family/PF00202 Phobius swissprot:GABT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GABT_ECOLI PhylomeDB P22256 http://phylomedb.org/?seqid=P22256 ProteinModelPortal P22256 http://www.proteinmodelportal.org/query/uniprot/P22256 PubMed 12446648 http://www.ncbi.nlm.nih.gov/pubmed/12446648 PubMed 14731280 http://www.ncbi.nlm.nih.gov/pubmed/14731280 PubMed 15323550 http://www.ncbi.nlm.nih.gov/pubmed/15323550 PubMed 15723541 http://www.ncbi.nlm.nih.gov/pubmed/15723541 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20639325 http://www.ncbi.nlm.nih.gov/pubmed/20639325 PubMed 2178550 http://www.ncbi.nlm.nih.gov/pubmed/2178550 PubMed 2254272 http://www.ncbi.nlm.nih.gov/pubmed/2254272 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417148 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417148 RefSeq WP_001087611 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001087611 SMR P22256 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P22256 STRING 511145.b2662 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2662&targetmode=cogs STRING COG0160 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0160&targetmode=cogs SUPFAM SSF53383 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53383 TIGRFAMs TIGR00700 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00700 UniProtKB GABT_ECOLI http://www.uniprot.org/uniprot/GABT_ECOLI UniProtKB-AC P22256 http://www.uniprot.org/uniprot/P22256 charge swissprot:GABT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GABT_ECOLI eggNOG COG0160 http://eggnogapi.embl.de/nog_data/html/tree/COG0160 eggNOG ENOG4108JPW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108JPW epestfind swissprot:GABT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GABT_ECOLI garnier swissprot:GABT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GABT_ECOLI helixturnhelix swissprot:GABT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GABT_ECOLI hmoment swissprot:GABT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GABT_ECOLI iep swissprot:GABT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GABT_ECOLI inforesidue swissprot:GABT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GABT_ECOLI octanol swissprot:GABT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GABT_ECOLI pepcoil swissprot:GABT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GABT_ECOLI pepdigest swissprot:GABT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GABT_ECOLI pepinfo swissprot:GABT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GABT_ECOLI pepnet swissprot:GABT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GABT_ECOLI pepstats swissprot:GABT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GABT_ECOLI pepwheel swissprot:GABT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GABT_ECOLI pepwindow swissprot:GABT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GABT_ECOLI sigcleave swissprot:GABT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GABT_ECOLI ## Database ID URL or Descriptions # BioGrid 4263278 7 # CDD cd06174 MFS # EcoGene EG11715 dgoT # FUNCTION DGOT_ECOLI Intake of galactonate into the cell. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IBA:GO_Central. # GO_function GO:0022857 transmembrane transporter activity; IBA:GO_Central. # GO_process GO:0006820 anion transport; IBA:GO_Central. # GO_process GO:0055085 transmembrane transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # InterPro IPR004744 Dgal_transporter # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # KEGG_Brite ko02000 Transporters # Organism DGOT_ECOLI Escherichia coli (strain K12) # PATRIC 32122877 VBIEscCol129921_3814 # PIR D65171 D65171 # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DGOT_ECOLI D-galactonate transporter # RefSeq NP_418146 NC_000913.3 # RefSeq WP_000354284 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA62043.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the major facilitator superfamily. Phthalate permease family. {ECO 0000305}. # SUBCELLULAR LOCATION DGOT_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.14 the major facilitator superfamily (mfs) # TIGRFAMs TIGR00893 2A0114 # eggNOG ENOG4105DJB Bacteria # eggNOG ENOG410XPWC LUCA BLAST swissprot:DGOT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DGOT_ECOLI BioCyc ECOL316407:JW5859-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5859-MONOMER BioCyc EcoCyc:YIDT-MONOMER http://biocyc.org/getid?id=EcoCyc:YIDT-MONOMER COG COG0477 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0477 DIP DIP-9436N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9436N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1666 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1666 EcoGene EG11715 http://www.ecogene.org/geneInfo.php?eg_id=EG11715 EnsemblBacteria AAC76714 http://www.ensemblgenomes.org/id/AAC76714 EnsemblBacteria AAC76714 http://www.ensemblgenomes.org/id/AAC76714 EnsemblBacteria BAE77603 http://www.ensemblgenomes.org/id/BAE77603 EnsemblBacteria BAE77603 http://www.ensemblgenomes.org/id/BAE77603 EnsemblBacteria BAE77603 http://www.ensemblgenomes.org/id/BAE77603 EnsemblBacteria b3691 http://www.ensemblgenomes.org/id/b3691 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GO_process GO:0006820 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006820 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 948196 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948196 HOGENOM HOG000113642 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000113642&db=HOGENOM6 InParanoid P0AA76 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AA76 InterPro IPR004744 http://www.ebi.ac.uk/interpro/entry/IPR004744 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5859 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5859 KEGG_Gene eco:b3691 http://www.genome.jp/dbget-bin/www_bget?eco:b3691 KEGG_Orthology KO:K08194 http://www.genome.jp/dbget-bin/www_bget?KO:K08194 OMA IWIMALM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IWIMALM PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:DGOT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DGOT_ECOLI PSORT-B swissprot:DGOT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DGOT_ECOLI PSORT2 swissprot:DGOT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DGOT_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:DGOT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DGOT_ECOLI PhylomeDB P0AA76 http://phylomedb.org/?seqid=P0AA76 ProteinModelPortal P0AA76 http://www.proteinmodelportal.org/query/uniprot/P0AA76 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418146 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418146 RefSeq WP_000354284 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000354284 STRING 511145.b3691 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3691&targetmode=cogs STRING COG0477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0477&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.14 http://www.tcdb.org/search/result.php?tc=2.A.1.14 TIGRFAMs TIGR00893 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00893 UniProtKB DGOT_ECOLI http://www.uniprot.org/uniprot/DGOT_ECOLI UniProtKB-AC P0AA76 http://www.uniprot.org/uniprot/P0AA76 charge swissprot:DGOT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DGOT_ECOLI eggNOG ENOG4105DJB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DJB eggNOG ENOG410XPWC http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPWC epestfind swissprot:DGOT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DGOT_ECOLI garnier swissprot:DGOT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DGOT_ECOLI helixturnhelix swissprot:DGOT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DGOT_ECOLI hmoment swissprot:DGOT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DGOT_ECOLI iep swissprot:DGOT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DGOT_ECOLI inforesidue swissprot:DGOT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DGOT_ECOLI octanol swissprot:DGOT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DGOT_ECOLI pepcoil swissprot:DGOT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DGOT_ECOLI pepdigest swissprot:DGOT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DGOT_ECOLI pepinfo swissprot:DGOT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DGOT_ECOLI pepnet swissprot:DGOT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DGOT_ECOLI pepstats swissprot:DGOT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DGOT_ECOLI pepwheel swissprot:DGOT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DGOT_ECOLI pepwindow swissprot:DGOT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DGOT_ECOLI sigcleave swissprot:DGOT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DGOT_ECOLI ## Database ID URL or Descriptions # BioGrid 4262636 7 # CDD cd06174 MFS # DISRUPTION PHENOTYPE Mutant fails to grow on sulfoquinovose as a sole carbon source. {ECO:0000269|PubMed 24463506}. # EcoGene EG11841 yihO # FUNCTION YIHO_ECOLI Could be involved in sulfoquinovose import. {ECO 0000269|PubMed 24463506}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:1901682 sulfur compound transmembrane transporter activity; IMP:EcoCyc. # GO_function YIHO_ECOLI GO 0015294 solute cation symporter activity; ISS EcoCyc. # GO_process GO:0006814 sodium ion transport; IEA:InterPro. # GO_process GO:0072348 sulfur compound transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR001927 Na/Gal_symport # InterPro IPR018043 Na/Gal_symport_CS # InterPro IPR020846 MFS_dom # Organism YIHO_ECOLI Escherichia coli (strain K12) # PATRIC 32123255 VBIEscCol129921_3988 # PROSITE PS00872 NA_GALACTOSIDE_SYMP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIHO_ECOLI Putative sulfoquinovose importer # RefSeq WP_001295267 NZ_LN832404.1 # RefSeq YP_026275 NC_000913.3 # SEQUENCE CAUTION Sequence=AAB03009.1; Type=Frameshift; Positions=463; Evidence={ECO 0000305}; # SIMILARITY Belongs to the sodium:galactoside symporter (TC 2.A.2) family. {ECO 0000305}. # SUBCELLULAR LOCATION YIHO_ECOLI Cell inner membrane {ECO 0000305}; Multi- pass membrane protein {ECO 0000305}. # SUPFAM SSF103473 SSF103473 # TIGRFAMs TIGR00792 gph # eggNOG COG2211 LUCA # eggNOG ENOG4105CT4 Bacteria BLAST swissprot:YIHO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIHO_ECOLI BioCyc ECOL316407:JW5852-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5852-MONOMER BioCyc EcoCyc:YIHO-MONOMER http://biocyc.org/getid?id=EcoCyc:YIHO-MONOMER COG COG2211 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2211 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature12947 http://dx.doi.org/10.1038/nature12947 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1787 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1787 EcoGene EG11841 http://www.ecogene.org/geneInfo.php?eg_id=EG11841 EnsemblBacteria AAT48233 http://www.ensemblgenomes.org/id/AAT48233 EnsemblBacteria AAT48233 http://www.ensemblgenomes.org/id/AAT48233 EnsemblBacteria BAE77433 http://www.ensemblgenomes.org/id/BAE77433 EnsemblBacteria BAE77433 http://www.ensemblgenomes.org/id/BAE77433 EnsemblBacteria BAE77433 http://www.ensemblgenomes.org/id/BAE77433 EnsemblBacteria b3876 http://www.ensemblgenomes.org/id/b3876 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015294 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015294 GO_function GO:1901682 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901682 GO_process GO:0006814 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814 GO_process GO:0072348 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072348 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948377 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948377 HOGENOM HOG000222020 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000222020&db=HOGENOM6 InParanoid P32136 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32136 InterPro IPR001927 http://www.ebi.ac.uk/interpro/entry/IPR001927 InterPro IPR018043 http://www.ebi.ac.uk/interpro/entry/IPR018043 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Gene ecj:JW5852 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5852 KEGG_Gene eco:b3876 http://www.genome.jp/dbget-bin/www_bget?eco:b3876 KEGG_Orthology KO:K03292 http://www.genome.jp/dbget-bin/www_bget?KO:K03292 OMA SIGYNGI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SIGYNGI PROSITE PS00872 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00872 PSORT swissprot:YIHO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIHO_ECOLI PSORT-B swissprot:YIHO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIHO_ECOLI PSORT2 swissprot:YIHO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIHO_ECOLI Phobius swissprot:YIHO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIHO_ECOLI PhylomeDB P32136 http://phylomedb.org/?seqid=P32136 ProteinModelPortal P32136 http://www.proteinmodelportal.org/query/uniprot/P32136 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 24463506 http://www.ncbi.nlm.nih.gov/pubmed/24463506 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001295267 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295267 RefSeq YP_026275 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026275 STRING 511145.b3876 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3876&targetmode=cogs STRING COG2211 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2211&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TIGRFAMs TIGR00792 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00792 UniProtKB YIHO_ECOLI http://www.uniprot.org/uniprot/YIHO_ECOLI UniProtKB-AC P32136 http://www.uniprot.org/uniprot/P32136 charge swissprot:YIHO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIHO_ECOLI eggNOG COG2211 http://eggnogapi.embl.de/nog_data/html/tree/COG2211 eggNOG ENOG4105CT4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CT4 epestfind swissprot:YIHO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIHO_ECOLI garnier swissprot:YIHO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIHO_ECOLI helixturnhelix swissprot:YIHO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIHO_ECOLI hmoment swissprot:YIHO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIHO_ECOLI iep swissprot:YIHO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIHO_ECOLI inforesidue swissprot:YIHO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIHO_ECOLI octanol swissprot:YIHO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIHO_ECOLI pepcoil swissprot:YIHO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIHO_ECOLI pepdigest swissprot:YIHO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIHO_ECOLI pepinfo swissprot:YIHO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIHO_ECOLI pepnet swissprot:YIHO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIHO_ECOLI pepstats swissprot:YIHO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIHO_ECOLI pepwheel swissprot:YIHO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIHO_ECOLI pepwindow swissprot:YIHO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIHO_ECOLI sigcleave swissprot:YIHO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIHO_ECOLI ## Database ID URL or Descriptions # AltName DEOD_ECOLI Inosine phosphorylase # BRENDA 2.4.2 2026 # BioGrid 4263006 3 # CATALYTIC ACTIVITY Purine deoxynucleoside + phosphate = purine + 2'-deoxy-alpha-D-ribose 1-phosphate. {ECO:0000305|PubMed 11786017}. # CATALYTIC ACTIVITY Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate. {ECO:0000305|PubMed 11786017}. # EcoGene EG10222 deoD # FUNCTION DEOD_ECOLI Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules. {ECO 0000269|PubMed 11786017}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0004731 purine-nucleoside phosphorylase activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IPI:IntAct. # GO_process GO:0006152 purine nucleoside catabolic process; IMP:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0019686 purine nucleoside interconversion; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_process GO:0006950 response to stress # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.1580 -; 1. # HAMAP MF_01627 Pur_nucleosid_phosp # INTERACTION DEOD_ECOLI Self; NbExp=7; IntAct=EBI-907568, EBI-907568; # IntAct P0ABP8 2 # InterPro IPR000845 Nucleoside_phosphorylase_d # InterPro IPR004402 DeoD-type # InterPro IPR018016 Nucleoside_phosphorylase_CS # InterPro IPR018017 Nucleoside_phosphorylase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00240 Pyrimidine metabolism # KEGG_Pathway ko00760 Nicotinate and nicotinamide metabolism # Organism DEOD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21234 PTHR21234 # PATRIC 32124384 VBIEscCol129921_4532 # PDB 1A69 X-ray; 2.10 A; A/B/C=2-239 # PDB 1ECP X-ray; 2.00 A; A/B/C/D/E/F=2-239 # PDB 1K9S X-ray; 2.00 A; A/B/C/D/E/F=2-238 # PDB 1OTX X-ray; 2.70 A; A/B/C=2-239 # PDB 1OTY X-ray; 2.50 A; A/B/C=2-239 # PDB 1OU4 X-ray; 2.50 A; A/B/C=2-239 # PDB 1OUM X-ray; 2.40 A; A/B/C=2-239 # PDB 1OV6 X-ray; 2.40 A; A/B/C=2-239 # PDB 1OVG X-ray; 2.20 A; A/B/C=2-239 # PDB 3ONV X-ray; 1.89 A; A/B/C=2-238 # PDB 3OOE X-ray; 2.00 A; A/B/C/D/E/F=2-238 # PDB 3OOH X-ray; 2.90 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R=2-238 # PDB 3OPV X-ray; 2.40 A; A/B/C/D/E/F/G/H/I/J/K/L=2-238 # PDB 3UT6 X-ray; 1.90 A; A/B/C=2-238 # PDB 4TS3 X-ray; 2.30 A; A/B/C/D/E/F=2-238 # PDB 4TS9 X-ray; 1.77 A; A/B/C=2-238 # PDB 4TTA X-ray; 2.00 A; A/B/C/D/E/F=2-238 # PDB 4TTI X-ray; 1.89 A; A/B/C/D/E/F=2-238 # PDB 4TTJ X-ray; 1.87 A; A/B/D=2-238 # PIR A41143 A27854 # PROSITE PS01232 PNP_UDP_1 # Pfam PF01048 PNP_UDP_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DEOD_ECOLI Purine nucleoside phosphorylase DeoD-type # RefSeq NP_418801 NC_000913.3 # RefSeq WP_000224877 NZ_LN832404.1 # SIMILARITY Belongs to the PNP/UDP phosphorylase family. {ECO 0000305}. # SUBUNIT DEOD_ECOLI Homohexamer. {ECO 0000269|PubMed 11786017, ECO 0000269|PubMed 9653038}. # SUPFAM SSF53167 SSF53167 # TIGRFAMs TIGR00107 deoD # eggNOG COG0813 LUCA # eggNOG ENOG4105D3A Bacteria BLAST swissprot:DEOD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DEOD_ECOLI BioCyc ECOL316407:JW4347-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4347-MONOMER BioCyc EcoCyc:DEOD-MONOMER http://biocyc.org/getid?id=EcoCyc:DEOD-MONOMER BioCyc MetaCyc:DEOD-MONOMER http://biocyc.org/getid?id=MetaCyc:DEOD-MONOMER COG COG0813 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0813 DIP DIP-36195N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36195N DOI 10.1006/jmbi.1998.1799 http://dx.doi.org/10.1006/jmbi.1998.1799 DOI 10.1006/jmbi.2001.5211 http://dx.doi.org/10.1006/jmbi.2001.5211 DOI 10.1016/S0969-2126(97)00287-6 http://dx.doi.org/10.1016/S0969-2126(97)00287-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.88.16.7185 http://dx.doi.org/10.1073/pnas.88.16.7185 DOI 10.1073/pnas.90.11.5011 http://dx.doi.org/10.1073/pnas.90.11.5011 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/nar/15.13.5125 http://dx.doi.org/10.1093/nar/15.13.5125 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.4.2.1 {ECO:0000305|PubMed:11786017} http://www.genome.jp/dbget-bin/www_bget?EC:2.4.2.1 {ECO:0000305|PubMed:11786017} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M60917 http://www.ebi.ac.uk/ena/data/view/M60917 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X05629 http://www.ebi.ac.uk/ena/data/view/X05629 ENZYME 2.4.2.1 {ECO:0000305|PubMed:11786017} http://enzyme.expasy.org/EC/2.4.2.1 {ECO:0000305|PubMed:11786017} EchoBASE EB0218 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0218 EcoGene EG10222 http://www.ecogene.org/geneInfo.php?eg_id=EG10222 EnsemblBacteria AAC77337 http://www.ensemblgenomes.org/id/AAC77337 EnsemblBacteria AAC77337 http://www.ensemblgenomes.org/id/AAC77337 EnsemblBacteria BAE78373 http://www.ensemblgenomes.org/id/BAE78373 EnsemblBacteria BAE78373 http://www.ensemblgenomes.org/id/BAE78373 EnsemblBacteria BAE78373 http://www.ensemblgenomes.org/id/BAE78373 EnsemblBacteria b4384 http://www.ensemblgenomes.org/id/b4384 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0004731 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004731 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0006152 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006152 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0019686 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019686 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.1580 http://www.cathdb.info/version/latest/superfamily/3.40.50.1580 GeneID 945654 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945654 HAMAP MF_01627 http://hamap.expasy.org/unirule/MF_01627 HOGENOM HOG000274896 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000274896&db=HOGENOM6 InParanoid P0ABP8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABP8 IntAct P0ABP8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABP8* IntEnz 2.4.2.1 {ECO:0000305|PubMed:11786017} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.2.1 {ECO:0000305|PubMed:11786017} InterPro IPR000845 http://www.ebi.ac.uk/interpro/entry/IPR000845 InterPro IPR004402 http://www.ebi.ac.uk/interpro/entry/IPR004402 InterPro IPR018016 http://www.ebi.ac.uk/interpro/entry/IPR018016 InterPro IPR018017 http://www.ebi.ac.uk/interpro/entry/IPR018017 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4347 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4347 KEGG_Gene eco:b4384 http://www.genome.jp/dbget-bin/www_bget?eco:b4384 KEGG_Orthology KO:K03784 http://www.genome.jp/dbget-bin/www_bget?KO:K03784 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Pathway ko00760 http://www.genome.jp/kegg-bin/show_pathway?ko00760 KEGG_Reaction rn:R01561 http://www.genome.jp/dbget-bin/www_bget?rn:R01561 KEGG_Reaction rn:R01863 http://www.genome.jp/dbget-bin/www_bget?rn:R01863 KEGG_Reaction rn:R01969 http://www.genome.jp/dbget-bin/www_bget?rn:R01969 KEGG_Reaction rn:R02147 http://www.genome.jp/dbget-bin/www_bget?rn:R02147 KEGG_Reaction rn:R02294 http://www.genome.jp/dbget-bin/www_bget?rn:R02294 KEGG_Reaction rn:R02295 http://www.genome.jp/dbget-bin/www_bget?rn:R02295 KEGG_Reaction rn:R02297 http://www.genome.jp/dbget-bin/www_bget?rn:R02297 KEGG_Reaction rn:R02484 http://www.genome.jp/dbget-bin/www_bget?rn:R02484 KEGG_Reaction rn:R02557 http://www.genome.jp/dbget-bin/www_bget?rn:R02557 KEGG_Reaction rn:R02748 http://www.genome.jp/dbget-bin/www_bget?rn:R02748 KEGG_Reaction rn:R08368 http://www.genome.jp/dbget-bin/www_bget?rn:R08368 MINT MINT-8328110 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8328110 OMA KDHDFSA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KDHDFSA PANTHER PTHR21234 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21234 PDB 1A69 http://www.ebi.ac.uk/pdbe-srv/view/entry/1A69 PDB 1ECP http://www.ebi.ac.uk/pdbe-srv/view/entry/1ECP PDB 1K9S http://www.ebi.ac.uk/pdbe-srv/view/entry/1K9S PDB 1OTX http://www.ebi.ac.uk/pdbe-srv/view/entry/1OTX PDB 1OTY http://www.ebi.ac.uk/pdbe-srv/view/entry/1OTY PDB 1OU4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1OU4 PDB 1OUM http://www.ebi.ac.uk/pdbe-srv/view/entry/1OUM PDB 1OV6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1OV6 PDB 1OVG http://www.ebi.ac.uk/pdbe-srv/view/entry/1OVG PDB 3ONV http://www.ebi.ac.uk/pdbe-srv/view/entry/3ONV PDB 3OOE http://www.ebi.ac.uk/pdbe-srv/view/entry/3OOE PDB 3OOH http://www.ebi.ac.uk/pdbe-srv/view/entry/3OOH PDB 3OPV http://www.ebi.ac.uk/pdbe-srv/view/entry/3OPV PDB 3UT6 http://www.ebi.ac.uk/pdbe-srv/view/entry/3UT6 PDB 4TS3 http://www.ebi.ac.uk/pdbe-srv/view/entry/4TS3 PDB 4TS9 http://www.ebi.ac.uk/pdbe-srv/view/entry/4TS9 PDB 4TTA http://www.ebi.ac.uk/pdbe-srv/view/entry/4TTA PDB 4TTI http://www.ebi.ac.uk/pdbe-srv/view/entry/4TTI PDB 4TTJ http://www.ebi.ac.uk/pdbe-srv/view/entry/4TTJ PDBsum 1A69 http://www.ebi.ac.uk/pdbsum/1A69 PDBsum 1ECP http://www.ebi.ac.uk/pdbsum/1ECP PDBsum 1K9S http://www.ebi.ac.uk/pdbsum/1K9S PDBsum 1OTX http://www.ebi.ac.uk/pdbsum/1OTX PDBsum 1OTY http://www.ebi.ac.uk/pdbsum/1OTY PDBsum 1OU4 http://www.ebi.ac.uk/pdbsum/1OU4 PDBsum 1OUM http://www.ebi.ac.uk/pdbsum/1OUM PDBsum 1OV6 http://www.ebi.ac.uk/pdbsum/1OV6 PDBsum 1OVG http://www.ebi.ac.uk/pdbsum/1OVG PDBsum 3ONV http://www.ebi.ac.uk/pdbsum/3ONV PDBsum 3OOE http://www.ebi.ac.uk/pdbsum/3OOE PDBsum 3OOH http://www.ebi.ac.uk/pdbsum/3OOH PDBsum 3OPV http://www.ebi.ac.uk/pdbsum/3OPV PDBsum 3UT6 http://www.ebi.ac.uk/pdbsum/3UT6 PDBsum 4TS3 http://www.ebi.ac.uk/pdbsum/4TS3 PDBsum 4TS9 http://www.ebi.ac.uk/pdbsum/4TS9 PDBsum 4TTA http://www.ebi.ac.uk/pdbsum/4TTA PDBsum 4TTI http://www.ebi.ac.uk/pdbsum/4TTI PDBsum 4TTJ http://www.ebi.ac.uk/pdbsum/4TTJ PROSITE PS01232 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01232 PSORT swissprot:DEOD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DEOD_ECOLI PSORT-B swissprot:DEOD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DEOD_ECOLI PSORT2 swissprot:DEOD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DEOD_ECOLI Pfam PF01048 http://pfam.xfam.org/family/PF01048 Phobius swissprot:DEOD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DEOD_ECOLI PhylomeDB P0ABP8 http://phylomedb.org/?seqid=P0ABP8 ProteinModelPortal P0ABP8 http://www.proteinmodelportal.org/query/uniprot/P0ABP8 PubMed 11786017 http://www.ncbi.nlm.nih.gov/pubmed/11786017 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1714590 http://www.ncbi.nlm.nih.gov/pubmed/1714590 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 3299264 http://www.ncbi.nlm.nih.gov/pubmed/3299264 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8506346 http://www.ncbi.nlm.nih.gov/pubmed/8506346 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9351810 http://www.ncbi.nlm.nih.gov/pubmed/9351810 PubMed 9653038 http://www.ncbi.nlm.nih.gov/pubmed/9653038 RefSeq NP_418801 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418801 RefSeq WP_000224877 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000224877 SMR P0ABP8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABP8 STRING 511145.b4384 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4384&targetmode=cogs STRING COG0813 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0813&targetmode=cogs SUPFAM SSF53167 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53167 SWISS-2DPAGE P0ABP8 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0ABP8 TIGRFAMs TIGR00107 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00107 UniProtKB DEOD_ECOLI http://www.uniprot.org/uniprot/DEOD_ECOLI UniProtKB-AC P0ABP8 http://www.uniprot.org/uniprot/P0ABP8 charge swissprot:DEOD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DEOD_ECOLI eggNOG COG0813 http://eggnogapi.embl.de/nog_data/html/tree/COG0813 eggNOG ENOG4105D3A http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D3A epestfind swissprot:DEOD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DEOD_ECOLI garnier swissprot:DEOD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DEOD_ECOLI helixturnhelix swissprot:DEOD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DEOD_ECOLI hmoment swissprot:DEOD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DEOD_ECOLI iep swissprot:DEOD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DEOD_ECOLI inforesidue swissprot:DEOD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DEOD_ECOLI octanol swissprot:DEOD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DEOD_ECOLI pepcoil swissprot:DEOD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DEOD_ECOLI pepdigest swissprot:DEOD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DEOD_ECOLI pepinfo swissprot:DEOD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DEOD_ECOLI pepnet swissprot:DEOD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DEOD_ECOLI pepstats swissprot:DEOD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DEOD_ECOLI pepwheel swissprot:DEOD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DEOD_ECOLI pepwindow swissprot:DEOD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DEOD_ECOLI sigcleave swissprot:DEOD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DEOD_ECOLI ## Database ID URL or Descriptions # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG12577 yjiP # GO_process GO:0044010 single-species biofilm formation; IMP:EcoCyc. # GOslim_process GO:0008150 biological_process # InterPro IPR006842 Transposase_31 # InterPro IPR010106 CHP01784 # Organism YJIP_ECOLI Escherichia coli (strain K12) # PATRIC 48668278 VBIEscCol107702_4389 # PIR S56563 S56563 # PIR S56564 S56564 # Pfam PF04754 Transposase_31 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJIP_ECOLI Putative uncharacterized protein YjiP # RefSeq WP_000181202 NZ_CP010444.1 # SEQUENCE CAUTION YJIP_ECOLI Sequence=AAA97234.1; Type=Erroneous termination; Positions=104; Note=Translated as Gln.; Evidence={ECO 0000305}; Sequence=AAA97235.1; Type=Erroneous termination; Positions=104; Note=Translated as Gln.; Evidence={ECO 0000305}; Sequence=BAE78331.1; Type=Erroneous termination; Positions=104; Note=Translated as Gln.; Evidence={ECO 0000305}; Sequence=U00096; Type=Erroneous termination; Positions=104; Note=Translated as Gln.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the YadD/YfaD/YhgA/YjiP family. {ECO 0000305}. # TIGRFAMs TIGR01784 T_den_put_tspse # eggNOG COG5464 LUCA BLAST swissprot:YJIP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJIP_ECOLI BioCyc ECOL316407:JW4302-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4302-MONOMER BioCyc EcoCyc:G7934-MONOMER http://biocyc.org/getid?id=EcoCyc:G7934-MONOMER BioCyc EcoCyc:G7935-MONOMER http://biocyc.org/getid?id=EcoCyc:G7935-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2465 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2465 EcoGene EG12577 http://www.ecogene.org/geneInfo.php?eg_id=EG12577 EnsemblBacteria BAE78331 http://www.ensemblgenomes.org/id/BAE78331 EnsemblBacteria BAE78331 http://www.ensemblgenomes.org/id/BAE78331 EnsemblBacteria BAE78331 http://www.ensemblgenomes.org/id/BAE78331 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0044010 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044010 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 HOGENOM HOG000116866 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000116866&db=HOGENOM6 InParanoid P39387 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39387 IntAct P39387 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39387* InterPro IPR006842 http://www.ebi.ac.uk/interpro/entry/IPR006842 InterPro IPR010106 http://www.ebi.ac.uk/interpro/entry/IPR010106 KEGG_Gene ecj:JW4302 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4302 OMA TRRMPHH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TRRMPHH PSORT swissprot:YJIP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJIP_ECOLI PSORT-B swissprot:YJIP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJIP_ECOLI PSORT2 swissprot:YJIP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJIP_ECOLI Pfam PF04754 http://pfam.xfam.org/family/PF04754 Phobius swissprot:YJIP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJIP_ECOLI PhylomeDB P39387 http://phylomedb.org/?seqid=P39387 ProteinModelPortal P39387 http://www.proteinmodelportal.org/query/uniprot/P39387 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000181202 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000181202 STRING 316407.85677081 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85677081&targetmode=cogs TIGRFAMs TIGR01784 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01784 UniProtKB YJIP_ECOLI http://www.uniprot.org/uniprot/YJIP_ECOLI UniProtKB-AC P39387 http://www.uniprot.org/uniprot/P39387 charge swissprot:YJIP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJIP_ECOLI eggNOG COG5464 http://eggnogapi.embl.de/nog_data/html/tree/COG5464 epestfind swissprot:YJIP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJIP_ECOLI garnier swissprot:YJIP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJIP_ECOLI helixturnhelix swissprot:YJIP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJIP_ECOLI hmoment swissprot:YJIP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJIP_ECOLI iep swissprot:YJIP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJIP_ECOLI inforesidue swissprot:YJIP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJIP_ECOLI octanol swissprot:YJIP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJIP_ECOLI pepcoil swissprot:YJIP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJIP_ECOLI pepdigest swissprot:YJIP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJIP_ECOLI pepinfo swissprot:YJIP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJIP_ECOLI pepnet swissprot:YJIP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJIP_ECOLI pepstats swissprot:YJIP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJIP_ECOLI pepwheel swissprot:YJIP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJIP_ECOLI pepwindow swissprot:YJIP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJIP_ECOLI sigcleave swissprot:YJIP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJIP_ECOLI ## Database ID URL or Descriptions # AltName RPPH_ECOLI (Di)nucleoside polyphosphate hydrolase # AltName RPPH_ECOLI Ap5A pyrophosphatase # BIOPHYSICOCHEMICAL PROPERTIES pH dependence Optimum pH is 8.5-9.0.; # BRENDA 3.6.1.61 2026 # BioGrid 4263204 41 # COFACTOR RPPH_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 11479323}; Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 11479323}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 11479323}; Note=Magnesium or zinc. Manganese can be used to a lesser extent. {ECO 0000269|PubMed 11479323}; # EcoGene EG13091 nudH # FUNCTION RPPH_ECOLI Master regulator of 5'-dependent mRNA decay. Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage. Preferentially hydrolyzes diadenosine penta-phosphate with ATP as one of the reaction products. Also able to hydrolyze diadenosine hexa- and tetra-phosphate. Has no activity on diadenosine tri-phosphate, ADP-ribose, NADH and UDP- glucose. In the meningitis causing strain E.coli K1, has been shown to play a role in HBMEC (human brain microvascular endothelial cells) invasion in vitro. {ECO 0000269|PubMed 10760174, ECO 0000269|PubMed 18202662}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IDA:EcoliWiki. # GO_function GO:0034353 RNA pyrophosphohydrolase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006402 mRNA catabolic process; IMP:EcoCyc. # GO_process GO:0050779 RNA destabilization; IMP:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # Gene3D 3.90.79.10 -; 1. # HAMAP MF_00298 Nudix_RppH # IntAct P0A776 55 # InterPro IPR000086 NUDIX_hydrolase_dom # InterPro IPR015797 NUDIX_hydrolase_dom-like # InterPro IPR020084 NUDIX_hydrolase_CS # InterPro IPR020476 Nudix_hydrolase # InterPro IPR022927 RppH # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko03018 RNA degradation # Organism RPPH_ECOLI Escherichia coli (strain K12) # PATRIC 32121078 VBIEscCol129921_2928 # PDB 2KDV NMR; -; A=1-164 # PDB 2KDW NMR; -; A=1-164 # PDB 4S2V X-ray; 1.70 A; A=1-156 # PDB 4S2W X-ray; 1.99 A; A=1-158 # PDB 4S2X X-ray; 1.50 A; A=1-158 # PDB 4S2Y X-ray; 1.60 A; A=1-158 # PIR G65065 G65065 # PRINTS PR00502 NUDIXFAMILY # PROSITE PS00893 NUDIX_BOX # PROSITE PS51462 NUDIX # Pfam PF00293 NUDIX # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RPPH_ECOLI RNA pyrophosphohydrolase # RefSeq NP_417307 NC_000913.3 # RefSeq WP_000564489 NZ_LN832404.1 # SIMILARITY Belongs to the Nudix hydrolase family. RppH subfamily. {ECO 0000305}. # SIMILARITY Contains 1 nudix hydrolase domain. {ECO 0000305}. # SUBUNIT Monomer. {ECO:0000269|PubMed 11479323}. # SUPFAM SSF55811 SSF55811 # eggNOG COG0494 LUCA # eggNOG ENOG4105EJF Bacteria BLAST swissprot:RPPH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RPPH_ECOLI BioCyc ECOL316407:JW2798-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2798-MONOMER BioCyc EcoCyc:G7459-MONOMER http://biocyc.org/getid?id=EcoCyc:G7459-MONOMER BioCyc MetaCyc:G7459-MONOMER http://biocyc.org/getid?id=MetaCyc:G7459-MONOMER COG COG0494 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0494 DIP DIP-47855N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47855N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature06475 http://dx.doi.org/10.1038/nature06475 DOI 10.1046/j.1365-2958.2000.01840.x http://dx.doi.org/10.1046/j.1365-2958.2000.01840.x DOI 10.1074/jbc.M107032200 http://dx.doi.org/10.1074/jbc.M107032200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.1.- http://www.genome.jp/dbget-bin/www_bget?EC:3.6.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 ENZYME 3.6.1.- http://enzyme.expasy.org/EC/3.6.1.- EchoBASE EB2896 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2896 EcoGene EG13091 http://www.ecogene.org/geneInfo.php?eg_id=EG13091 EnsemblBacteria AAC75869 http://www.ensemblgenomes.org/id/AAC75869 EnsemblBacteria AAC75869 http://www.ensemblgenomes.org/id/AAC75869 EnsemblBacteria BAE76899 http://www.ensemblgenomes.org/id/BAE76899 EnsemblBacteria BAE76899 http://www.ensemblgenomes.org/id/BAE76899 EnsemblBacteria BAE76899 http://www.ensemblgenomes.org/id/BAE76899 EnsemblBacteria b2830 http://www.ensemblgenomes.org/id/b2830 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0016818 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016818 GO_function GO:0034353 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034353 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006402 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006402 GO_process GO:0050779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050779 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 Gene3D 3.90.79.10 http://www.cathdb.info/version/latest/superfamily/3.90.79.10 GeneID 947300 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947300 HAMAP MF_00298 http://hamap.expasy.org/unirule/MF_00298 HOGENOM HOG000066723 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000066723&db=HOGENOM6 InParanoid P0A776 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A776 IntAct P0A776 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A776* IntEnz 3.6.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.1 InterPro IPR000086 http://www.ebi.ac.uk/interpro/entry/IPR000086 InterPro IPR015797 http://www.ebi.ac.uk/interpro/entry/IPR015797 InterPro IPR020084 http://www.ebi.ac.uk/interpro/entry/IPR020084 InterPro IPR020476 http://www.ebi.ac.uk/interpro/entry/IPR020476 InterPro IPR022927 http://www.ebi.ac.uk/interpro/entry/IPR022927 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2798 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2798 KEGG_Gene eco:b2830 http://www.genome.jp/dbget-bin/www_bget?eco:b2830 KEGG_Orthology KO:K08311 http://www.genome.jp/dbget-bin/www_bget?KO:K08311 KEGG_Pathway ko03018 http://www.genome.jp/kegg-bin/show_pathway?ko03018 OMA QNAWQFP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QNAWQFP PDB 2KDV http://www.ebi.ac.uk/pdbe-srv/view/entry/2KDV PDB 2KDW http://www.ebi.ac.uk/pdbe-srv/view/entry/2KDW PDB 4S2V http://www.ebi.ac.uk/pdbe-srv/view/entry/4S2V PDB 4S2W http://www.ebi.ac.uk/pdbe-srv/view/entry/4S2W PDB 4S2X http://www.ebi.ac.uk/pdbe-srv/view/entry/4S2X PDB 4S2Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4S2Y PDBsum 2KDV http://www.ebi.ac.uk/pdbsum/2KDV PDBsum 2KDW http://www.ebi.ac.uk/pdbsum/2KDW PDBsum 4S2V http://www.ebi.ac.uk/pdbsum/4S2V PDBsum 4S2W http://www.ebi.ac.uk/pdbsum/4S2W PDBsum 4S2X http://www.ebi.ac.uk/pdbsum/4S2X PDBsum 4S2Y http://www.ebi.ac.uk/pdbsum/4S2Y PRINTS PR00502 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00502 PROSITE PS00893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00893 PROSITE PS51462 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51462 PSORT swissprot:RPPH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RPPH_ECOLI PSORT-B swissprot:RPPH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RPPH_ECOLI PSORT2 swissprot:RPPH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RPPH_ECOLI Pfam PF00293 http://pfam.xfam.org/family/PF00293 Phobius swissprot:RPPH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RPPH_ECOLI PhylomeDB P0A776 http://phylomedb.org/?seqid=P0A776 ProteinModelPortal P0A776 http://www.proteinmodelportal.org/query/uniprot/P0A776 PubMed 10760174 http://www.ncbi.nlm.nih.gov/pubmed/10760174 PubMed 11479323 http://www.ncbi.nlm.nih.gov/pubmed/11479323 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18202662 http://www.ncbi.nlm.nih.gov/pubmed/18202662 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417307 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417307 RefSeq WP_000564489 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000564489 SMR P0A776 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A776 STRING 511145.b2830 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2830&targetmode=cogs STRING COG0494 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0494&targetmode=cogs SUPFAM SSF55811 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55811 UniProtKB RPPH_ECOLI http://www.uniprot.org/uniprot/RPPH_ECOLI UniProtKB-AC P0A776 http://www.uniprot.org/uniprot/P0A776 charge swissprot:RPPH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RPPH_ECOLI eggNOG COG0494 http://eggnogapi.embl.de/nog_data/html/tree/COG0494 eggNOG ENOG4105EJF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EJF epestfind swissprot:RPPH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RPPH_ECOLI garnier swissprot:RPPH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RPPH_ECOLI helixturnhelix swissprot:RPPH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RPPH_ECOLI hmoment swissprot:RPPH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RPPH_ECOLI iep swissprot:RPPH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RPPH_ECOLI inforesidue swissprot:RPPH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RPPH_ECOLI octanol swissprot:RPPH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RPPH_ECOLI pepcoil swissprot:RPPH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RPPH_ECOLI pepdigest swissprot:RPPH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RPPH_ECOLI pepinfo swissprot:RPPH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RPPH_ECOLI pepnet swissprot:RPPH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RPPH_ECOLI pepstats swissprot:RPPH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RPPH_ECOLI pepwheel swissprot:RPPH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RPPH_ECOLI pepwindow swissprot:RPPH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RPPH_ECOLI sigcleave swissprot:RPPH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RPPH_ECOLI ## Database ID URL or Descriptions # Organism YUBK_ECOLI Escherichia coli (strain K12) # RecName YUBK_ECOLI Uncharacterized serine-rich protein YubK # RefSeq NP_061438 NC_002483.1 # RefSeq WP_010892538 NC_002483.1 BLAST swissprot:YUBK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YUBK_ECOLI EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1263590 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263590 OMA CYCSSSF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CYCSSSF PSORT swissprot:YUBK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YUBK_ECOLI PSORT-B swissprot:YUBK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YUBK_ECOLI PSORT2 swissprot:YUBK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YUBK_ECOLI Phobius swissprot:YUBK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YUBK_ECOLI ProteinModelPortal Q9JMR4 http://www.proteinmodelportal.org/query/uniprot/Q9JMR4 RefSeq NP_061438 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061438 RefSeq WP_010892538 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_010892538 UniProtKB YUBK_ECOLI http://www.uniprot.org/uniprot/YUBK_ECOLI UniProtKB-AC Q9JMR4 http://www.uniprot.org/uniprot/Q9JMR4 charge swissprot:YUBK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YUBK_ECOLI epestfind swissprot:YUBK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YUBK_ECOLI garnier swissprot:YUBK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YUBK_ECOLI helixturnhelix swissprot:YUBK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YUBK_ECOLI hmoment swissprot:YUBK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YUBK_ECOLI iep swissprot:YUBK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YUBK_ECOLI inforesidue swissprot:YUBK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YUBK_ECOLI octanol swissprot:YUBK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YUBK_ECOLI pepcoil swissprot:YUBK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YUBK_ECOLI pepdigest swissprot:YUBK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YUBK_ECOLI pepinfo swissprot:YUBK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YUBK_ECOLI pepnet swissprot:YUBK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YUBK_ECOLI pepstats swissprot:YUBK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YUBK_ECOLI pepwheel swissprot:YUBK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YUBK_ECOLI pepwindow swissprot:YUBK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YUBK_ECOLI sigcleave swissprot:YUBK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YUBK_ECOLI ## Database ID URL or Descriptions # EcoGene EG14431 dinQ # GO_component GO:0016020 membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0006950 response to stress # INDUCTION DINQ_ECOLI By DNA-damaging conditions. Repressed by LexA. # Organism DINQ_ECOLI Escherichia coli (strain K12) # PATRIC 32122452 VBIEscCol129921_3603 # Proteomes UP000000625 Chromosome # RecName DINQ_ECOLI Uncharacterized protein DinQ # RefSeq YP_001165328 NC_000913.3 # SIMILARITY Belongs to the DinQ family. {ECO 0000305}. # SUBCELLULAR LOCATION DINQ_ECOLI Membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. BLAST swissprot:DINQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DINQ_ECOLI BioCyc EcoCyc:MONOMER0-1941 http://biocyc.org/getid?id=EcoCyc:MONOMER0-1941 DOI 10.1046/j.1365-2958.2000.01826.x http://dx.doi.org/10.1046/j.1365-2958.2000.01826.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14431 http://www.ecogene.org/geneInfo.php?eg_id=EG14431 EnsemblBacteria ABP93453 http://www.ensemblgenomes.org/id/ABP93453 EnsemblBacteria ABP93453 http://www.ensemblgenomes.org/id/ABP93453 EnsemblBacteria b4613 http://www.ensemblgenomes.org/id/b4613 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 5061522 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5061522 HOGENOM HOG000009624 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009624&db=HOGENOM6 KEGG_Gene eco:b4613 http://www.genome.jp/dbget-bin/www_bget?eco:b4613 PSORT swissprot:DINQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DINQ_ECOLI PSORT-B swissprot:DINQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DINQ_ECOLI PSORT2 swissprot:DINQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DINQ_ECOLI Phobius swissprot:DINQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DINQ_ECOLI PubMed 10760155 http://www.ncbi.nlm.nih.gov/pubmed/10760155 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq YP_001165328 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001165328 STRING 511145.b4613 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4613&targetmode=cogs UniProtKB DINQ_ECOLI http://www.uniprot.org/uniprot/DINQ_ECOLI UniProtKB-AC A5A624 http://www.uniprot.org/uniprot/A5A624 charge swissprot:DINQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DINQ_ECOLI epestfind swissprot:DINQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DINQ_ECOLI garnier swissprot:DINQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DINQ_ECOLI helixturnhelix swissprot:DINQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DINQ_ECOLI hmoment swissprot:DINQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DINQ_ECOLI iep swissprot:DINQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DINQ_ECOLI inforesidue swissprot:DINQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DINQ_ECOLI octanol swissprot:DINQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DINQ_ECOLI pepcoil swissprot:DINQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DINQ_ECOLI pepdigest swissprot:DINQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DINQ_ECOLI pepinfo swissprot:DINQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DINQ_ECOLI pepnet swissprot:DINQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DINQ_ECOLI pepstats swissprot:DINQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DINQ_ECOLI pepwheel swissprot:DINQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DINQ_ECOLI pepwindow swissprot:DINQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DINQ_ECOLI sigcleave swissprot:DINQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DINQ_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES NUDC_ECOLI Kinetic parameters KM=0.11 mM for NADH {ECO 0000269|PubMed 7829480}; KM=5.1 mM for NAD(+) {ECO 0000269|PubMed 7829480}; KM=0.29 mM for deamino-NADH {ECO 0000269|PubMed 7829480}; KM=2.6 mM for deamino-NAD(+) {ECO 0000269|PubMed 7829480}; KM=0.67 mM for AppA {ECO 0000269|PubMed 7829480}; KM=1.8 mM for ADP-ribose {ECO 0000269|PubMed 7829480}; Vmax=7.6 umol/min/mg enzyme with NADH as substrate {ECO 0000269|PubMed 7829480}; Vmax=2.9 umol/min/mg enzyme with NAD(+) as substrate {ECO 0000269|PubMed 7829480}; Vmax=8.9 umol/min/mg enzyme with deamino-NADH as substrate {ECO 0000269|PubMed 7829480}; Vmax=3.2 umol/min/mg enzyme with deamino-NAD(+) as substrate {ECO 0000269|PubMed 7829480}; Vmax=4.7 umol/min/mg enzyme with AppA as substrate {ECO 0000269|PubMed 7829480}; Vmax=4.8 umol/min/mg enzyme with ADP-ribose as substrate {ECO 0000269|PubMed 7829480}; pH dependence Optimum pH is 8.5. {ECO 0000269|PubMed 7829480}; # BioGrid 4263215 134 # CATALYTIC ACTIVITY NAD(H) + H(2)O = AMP + NMN(H). {ECO:0000269|PubMed 7829480}. # COFACTOR NUDC_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 7829480}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 7829480}; Note=Divalent metal cations. Mg(2+) or Mn(2+). {ECO 0000269|PubMed 7829480}; # COFACTOR NUDC_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|Ref.7}; Note=Binds 1 zinc ion per subunit. {ECO 0000269|Ref.7}; # EcoGene EG11702 nudC # FUNCTION NUDC_ECOLI Catalyzes the hydrolysis of a broad range of dinucleotide pyrophosphates, but uniquely prefers the reduced form of NADH. {ECO 0000269|PubMed 7829480}. # GO_function GO:0000210 NAD+ diphosphatase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008270 zinc ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0030145 manganese ion binding; IDA:EcoCyc. # GO_function GO:0035529 NADH pyrophosphatase activity; IDA:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # Gene3D 3.90.79.10 -; 1. # HAMAP MF_00297 Nudix_NudC # InterPro IPR000086 NUDIX_hydrolase_dom # InterPro IPR015376 Znr_NADH_PPase # InterPro IPR015797 NUDIX_hydrolase_dom-like # InterPro IPR020084 NUDIX_hydrolase_CS # InterPro IPR022925 NADH_pyroPase_NudC # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00760 Nicotinate and nicotinamide metabolism # KEGG_Pathway ko04146 Peroxisome # Organism NUDC_ECOLI Escherichia coli (strain K12) # PATRIC 32123515 VBIEscCol129921_4110 # PDB 1VK6 X-ray; 2.20 A; A=1-257 # PDB 2GB5 X-ray; 2.30 A; A/B=1-257 # PDB 5ISY X-ray; 2.35 A; A/C=1-257 # PIR G65206 G65206 # PROSITE PS00893 NUDIX_BOX # PROSITE PS51462 NUDIX # Pfam PF00293 NUDIX # Pfam PF09297 zf-NADH-PPase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NADH pyrophosphatase {ECO:0000303|PubMed 7829480} # RefSeq WP_000373940 NZ_LN832404.1 # RefSeq YP_026280 NC_000913.3 # SEQUENCE CAUTION Sequence=D12624; Type=Frameshift; Positions=116; Evidence={ECO 0000305}; # SIMILARITY Belongs to the Nudix hydrolase family. NudC subfamily. {ECO 0000305}. # SIMILARITY Contains 1 nudix hydrolase domain. {ECO:0000255|PROSITE-ProRule PRU00794}. # SUBUNIT Homodimer. {ECO:0000305|PubMed 7829480, ECO:0000305|Ref.7}. # SUPFAM SSF55811 SSF55811; 2 # eggNOG COG2816 LUCA # eggNOG ENOG4105E09 Bacteria BLAST swissprot:NUDC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NUDC_ECOLI BioCyc ECOL316407:JW5548-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5548-MONOMER BioCyc EcoCyc:EG11702-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11702-MONOMER BioCyc MetaCyc:EG11702-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11702-MONOMER COG COG2816 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2816 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.270.4.1529 http://dx.doi.org/10.1074/jbc.270.4.1529 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.1.22 {ECO:0000269|PubMed:7829480} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.1.22 {ECO:0000269|PubMed:7829480} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D12624 http://www.ebi.ac.uk/ena/data/view/D12624 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.6.1.22 {ECO:0000269|PubMed:7829480} http://enzyme.expasy.org/EC/3.6.1.22 {ECO:0000269|PubMed:7829480} EchoBASE EB1653 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1653 EcoGene EG11702 http://www.ecogene.org/geneInfo.php?eg_id=EG11702 EnsemblBacteria AAT48238 http://www.ensemblgenomes.org/id/AAT48238 EnsemblBacteria AAT48238 http://www.ensemblgenomes.org/id/AAT48238 EnsemblBacteria BAE77323 http://www.ensemblgenomes.org/id/BAE77323 EnsemblBacteria BAE77323 http://www.ensemblgenomes.org/id/BAE77323 EnsemblBacteria BAE77323 http://www.ensemblgenomes.org/id/BAE77323 EnsemblBacteria b3996 http://www.ensemblgenomes.org/id/b3996 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000210 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000210 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_function GO:0035529 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035529 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.90.79.10 http://www.cathdb.info/version/latest/superfamily/3.90.79.10 GeneID 948498 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948498 HAMAP MF_00297 http://hamap.expasy.org/unirule/MF_00297 HOGENOM HOG000247937 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000247937&db=HOGENOM6 InParanoid P32664 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32664 IntAct P32664 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32664* IntEnz 3.6.1.22 {ECO:0000269|PubMed:7829480} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.1.22 {ECO:0000269|PubMed:7829480} InterPro IPR000086 http://www.ebi.ac.uk/interpro/entry/IPR000086 InterPro IPR015376 http://www.ebi.ac.uk/interpro/entry/IPR015376 InterPro IPR015797 http://www.ebi.ac.uk/interpro/entry/IPR015797 InterPro IPR020084 http://www.ebi.ac.uk/interpro/entry/IPR020084 InterPro IPR022925 http://www.ebi.ac.uk/interpro/entry/IPR022925 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5548 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5548 KEGG_Gene eco:b3996 http://www.genome.jp/dbget-bin/www_bget?eco:b3996 KEGG_Orthology KO:K03426 http://www.genome.jp/dbget-bin/www_bget?KO:K03426 KEGG_Pathway ko00760 http://www.genome.jp/kegg-bin/show_pathway?ko00760 KEGG_Pathway ko04146 http://www.genome.jp/kegg-bin/show_pathway?ko04146 KEGG_Reaction rn:R00103 http://www.genome.jp/dbget-bin/www_bget?rn:R00103 KEGG_Reaction rn:R03004 http://www.genome.jp/dbget-bin/www_bget?rn:R03004 OMA FERFDEW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FERFDEW PDB 1VK6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1VK6 PDB 2GB5 http://www.ebi.ac.uk/pdbe-srv/view/entry/2GB5 PDB 5ISY http://www.ebi.ac.uk/pdbe-srv/view/entry/5ISY PDBsum 1VK6 http://www.ebi.ac.uk/pdbsum/1VK6 PDBsum 2GB5 http://www.ebi.ac.uk/pdbsum/2GB5 PDBsum 5ISY http://www.ebi.ac.uk/pdbsum/5ISY PROSITE PS00893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00893 PROSITE PS51462 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51462 PSORT swissprot:NUDC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NUDC_ECOLI PSORT-B swissprot:NUDC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NUDC_ECOLI PSORT2 swissprot:NUDC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NUDC_ECOLI Pfam PF00293 http://pfam.xfam.org/family/PF00293 Pfam PF09297 http://pfam.xfam.org/family/PF09297 Phobius swissprot:NUDC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NUDC_ECOLI PhylomeDB P32664 http://phylomedb.org/?seqid=P32664 ProteinModelPortal P32664 http://www.proteinmodelportal.org/query/uniprot/P32664 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7829480 http://www.ncbi.nlm.nih.gov/pubmed/7829480 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000373940 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000373940 RefSeq YP_026280 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026280 SMR P32664 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32664 STRING 511145.b3996 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3996&targetmode=cogs STRING COG2816 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2816&targetmode=cogs SUPFAM SSF55811 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55811 UniProtKB NUDC_ECOLI http://www.uniprot.org/uniprot/NUDC_ECOLI UniProtKB-AC P32664 http://www.uniprot.org/uniprot/P32664 charge swissprot:NUDC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NUDC_ECOLI eggNOG COG2816 http://eggnogapi.embl.de/nog_data/html/tree/COG2816 eggNOG ENOG4105E09 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E09 epestfind swissprot:NUDC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NUDC_ECOLI garnier swissprot:NUDC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NUDC_ECOLI helixturnhelix swissprot:NUDC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NUDC_ECOLI hmoment swissprot:NUDC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NUDC_ECOLI iep swissprot:NUDC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NUDC_ECOLI inforesidue swissprot:NUDC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NUDC_ECOLI octanol swissprot:NUDC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NUDC_ECOLI pepcoil swissprot:NUDC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NUDC_ECOLI pepdigest swissprot:NUDC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NUDC_ECOLI pepinfo swissprot:NUDC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NUDC_ECOLI pepnet swissprot:NUDC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NUDC_ECOLI pepstats swissprot:NUDC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NUDC_ECOLI pepwheel swissprot:NUDC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NUDC_ECOLI pepwindow swissprot:NUDC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NUDC_ECOLI sigcleave swissprot:NUDC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NUDC_ECOLI ## Database ID URL or Descriptions # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # Organism YUAP_ECOLI Escherichia coli (strain K12) # RecName YUAP_ECOLI Uncharacterized membrane protein YuaP # RefSeq NP_061406 NC_002483.1 # RefSeq WP_010892529 NC_002483.1 # SUBCELLULAR LOCATION YUAP_ECOLI Membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. BLAST swissprot:YUAP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YUAP_ECOLI EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GeneID 1263528 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263528 PSORT swissprot:YUAP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YUAP_ECOLI PSORT-B swissprot:YUAP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YUAP_ECOLI PSORT2 swissprot:YUAP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YUAP_ECOLI Phobius swissprot:YUAP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YUAP_ECOLI ProteinModelPortal Q9JMS4 http://www.proteinmodelportal.org/query/uniprot/Q9JMS4 RefSeq NP_061406 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061406 RefSeq WP_010892529 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_010892529 UniProtKB YUAP_ECOLI http://www.uniprot.org/uniprot/YUAP_ECOLI UniProtKB-AC Q9JMS4 http://www.uniprot.org/uniprot/Q9JMS4 charge swissprot:YUAP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YUAP_ECOLI epestfind swissprot:YUAP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YUAP_ECOLI garnier swissprot:YUAP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YUAP_ECOLI helixturnhelix swissprot:YUAP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YUAP_ECOLI hmoment swissprot:YUAP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YUAP_ECOLI iep swissprot:YUAP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YUAP_ECOLI inforesidue swissprot:YUAP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YUAP_ECOLI octanol swissprot:YUAP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YUAP_ECOLI pepcoil swissprot:YUAP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YUAP_ECOLI pepdigest swissprot:YUAP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YUAP_ECOLI pepinfo swissprot:YUAP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YUAP_ECOLI pepnet swissprot:YUAP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YUAP_ECOLI pepstats swissprot:YUAP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YUAP_ECOLI pepwheel swissprot:YUAP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YUAP_ECOLI pepwindow swissprot:YUAP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YUAP_ECOLI sigcleave swissprot:YUAP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YUAP_ECOLI ## Database ID URL or Descriptions # BioGrid 4260318 116 # EcoGene EG14000 ydjX # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR015414 TMEM64/TMEM41 # InterPro IPR032816 SNARE_assoc # Organism YDJX_ECOLI Escherichia coli (strain K12) # PANTHER PTHR12677 PTHR12677 # PATRIC 32118811 VBIEscCol129921_1823 # PIR F64934 F64934 # Pfam PF09335 SNARE_assoc # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDJX_ECOLI TVP38/TMEM64 family membrane protein YdjX # RefSeq NP_416264 NC_000913.3 # RefSeq WP_001300395 NZ_LN832404.1 # SIMILARITY Belongs to the TVP38/TMEM64 family. {ECO 0000305}. # SUBCELLULAR LOCATION YDJX_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # TCDB 9.B.27.1 the deda or ydjx-z (deda) family # eggNOG COG0398 LUCA # eggNOG ENOG4108RSN Bacteria BLAST swissprot:YDJX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDJX_ECOLI BioCyc ECOL316407:JW1739-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1739-MONOMER BioCyc EcoCyc:G6945-MONOMER http://biocyc.org/getid?id=EcoCyc:G6945-MONOMER DIP DIP-11779N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11779N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3756 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3756 EcoGene EG14000 http://www.ecogene.org/geneInfo.php?eg_id=EG14000 EnsemblBacteria AAC74820 http://www.ensemblgenomes.org/id/AAC74820 EnsemblBacteria AAC74820 http://www.ensemblgenomes.org/id/AAC74820 EnsemblBacteria BAA15541 http://www.ensemblgenomes.org/id/BAA15541 EnsemblBacteria BAA15541 http://www.ensemblgenomes.org/id/BAA15541 EnsemblBacteria BAA15541 http://www.ensemblgenomes.org/id/BAA15541 EnsemblBacteria b1750 http://www.ensemblgenomes.org/id/b1750 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 946250 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946250 HOGENOM HOG000121087 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000121087&db=HOGENOM6 InParanoid P76219 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76219 IntAct P76219 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76219* InterPro IPR015414 http://www.ebi.ac.uk/interpro/entry/IPR015414 InterPro IPR032816 http://www.ebi.ac.uk/interpro/entry/IPR032816 KEGG_Gene ecj:JW1739 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1739 KEGG_Gene eco:b1750 http://www.genome.jp/dbget-bin/www_bget?eco:b1750 OMA ISHFGVW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ISHFGVW PANTHER PTHR12677 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12677 PSORT swissprot:YDJX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDJX_ECOLI PSORT-B swissprot:YDJX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDJX_ECOLI PSORT2 swissprot:YDJX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDJX_ECOLI Pfam PF09335 http://pfam.xfam.org/family/PF09335 Phobius swissprot:YDJX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDJX_ECOLI PhylomeDB P76219 http://phylomedb.org/?seqid=P76219 ProteinModelPortal P76219 http://www.proteinmodelportal.org/query/uniprot/P76219 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416264 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416264 RefSeq WP_001300395 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300395 STRING 511145.b1750 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1750&targetmode=cogs TCDB 9.B.27.1 http://www.tcdb.org/search/result.php?tc=9.B.27.1 UniProtKB YDJX_ECOLI http://www.uniprot.org/uniprot/YDJX_ECOLI UniProtKB-AC P76219 http://www.uniprot.org/uniprot/P76219 charge swissprot:YDJX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDJX_ECOLI eggNOG COG0398 http://eggnogapi.embl.de/nog_data/html/tree/COG0398 eggNOG ENOG4108RSN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108RSN epestfind swissprot:YDJX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDJX_ECOLI garnier swissprot:YDJX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDJX_ECOLI helixturnhelix swissprot:YDJX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDJX_ECOLI hmoment swissprot:YDJX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDJX_ECOLI iep swissprot:YDJX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDJX_ECOLI inforesidue swissprot:YDJX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDJX_ECOLI octanol swissprot:YDJX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDJX_ECOLI pepcoil swissprot:YDJX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDJX_ECOLI pepdigest swissprot:YDJX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDJX_ECOLI pepinfo swissprot:YDJX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDJX_ECOLI pepnet swissprot:YDJX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDJX_ECOLI pepstats swissprot:YDJX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDJX_ECOLI pepwheel swissprot:YDJX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDJX_ECOLI pepwindow swissprot:YDJX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDJX_ECOLI sigcleave swissprot:YDJX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDJX_ECOLI ## Database ID URL or Descriptions # AltName GFCE_ECOLI Group 4 capsule protein E homolog # BioGrid 4261408 162 # CAUTION In E.coli K12 / MG1655 and K12 / W3110 this operon is silenced by an IS1D insertion in the promoter region. {ECO 0000305}. # EcoGene EG13728 gfcE # FUNCTION GFCE_ECOLI May be involved in polysaccharide transport. # GO_component GO:0009279 cell outer membrane; IEA:UniProtKB-SubCell. # GO_component GO:0046930 pore complex; IEA:UniProtKB-KW. # GO_function GO:0015159 polysaccharide transmembrane transporter activity; IEA:InterPro. # GO_function GO:0015288 porin activity; IEA:UniProtKB-KW. # GO_process GO:0006811 ion transport; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043234 protein complex # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR003715 Poly_export # InterPro IPR019554 Soluble_ligand-bd # KEGG_Brite ko02000 Transporters # Organism GFCE_ECOLI Escherichia coli (strain K12) # PATRIC 32117189 VBIEscCol129921_1018 # PIR E64839 E64839 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF02563 Poly_export # Pfam PF10531 SLBB; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GFCE_ECOLI Putative polysaccharide export protein GfcE # RefSeq NP_415503 NC_000913.3 # RefSeq WP_001295357 NZ_LN832404.1 # SIMILARITY Belongs to the BexD/CtrA/VexA family. {ECO 0000305}. # SUBCELLULAR LOCATION GFCE_ECOLI Cell outer membrane {ECO 0000250}; Multi- pass membrane protein {ECO 0000250}. # TCDB 1.B.18.3 the outer membrane auxiliary (oma) protein family # eggNOG COG1596 LUCA # eggNOG ENOG4105DAY Bacteria BLAST swissprot:GFCE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GFCE_ECOLI BioCyc ECOL316407:JW0966-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0966-MONOMER BioCyc EcoCyc:G6504-MONOMER http://biocyc.org/getid?id=EcoCyc:G6504-MONOMER COG COG1596 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1596 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3492 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3492 EcoGene EG13728 http://www.ecogene.org/geneInfo.php?eg_id=EG13728 EnsemblBacteria AAC74068 http://www.ensemblgenomes.org/id/AAC74068 EnsemblBacteria AAC74068 http://www.ensemblgenomes.org/id/AAC74068 EnsemblBacteria BAA35748 http://www.ensemblgenomes.org/id/BAA35748 EnsemblBacteria BAA35748 http://www.ensemblgenomes.org/id/BAA35748 EnsemblBacteria BAA35748 http://www.ensemblgenomes.org/id/BAA35748 EnsemblBacteria b0983 http://www.ensemblgenomes.org/id/b0983 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0046930 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046930 GO_function GO:0015159 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015159 GO_function GO:0015288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015288 GO_process GO:0006811 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 945586 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945586 HOGENOM HOG000153886 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000153886&db=HOGENOM6 InParanoid P0A932 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A932 InterPro IPR003715 http://www.ebi.ac.uk/interpro/entry/IPR003715 InterPro IPR019554 http://www.ebi.ac.uk/interpro/entry/IPR019554 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0966 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0966 KEGG_Gene eco:b0983 http://www.genome.jp/dbget-bin/www_bget?eco:b0983 KEGG_Orthology KO:K01991 http://www.genome.jp/dbget-bin/www_bget?KO:K01991 OMA VPRNDSQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VPRNDSQ PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:GFCE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GFCE_ECOLI PSORT-B swissprot:GFCE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GFCE_ECOLI PSORT2 swissprot:GFCE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GFCE_ECOLI Pfam PF02563 http://pfam.xfam.org/family/PF02563 Pfam PF10531 http://pfam.xfam.org/family/PF10531 Phobius swissprot:GFCE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GFCE_ECOLI PhylomeDB P0A932 http://phylomedb.org/?seqid=P0A932 ProteinModelPortal P0A932 http://www.proteinmodelportal.org/query/uniprot/P0A932 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415503 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415503 RefSeq WP_001295357 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295357 SMR P0A932 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A932 STRING 511145.b0983 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0983&targetmode=cogs STRING COG1596 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1596&targetmode=cogs TCDB 1.B.18.3 http://www.tcdb.org/search/result.php?tc=1.B.18.3 UniProtKB GFCE_ECOLI http://www.uniprot.org/uniprot/GFCE_ECOLI UniProtKB-AC P0A932 http://www.uniprot.org/uniprot/P0A932 charge swissprot:GFCE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GFCE_ECOLI eggNOG COG1596 http://eggnogapi.embl.de/nog_data/html/tree/COG1596 eggNOG ENOG4105DAY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DAY epestfind swissprot:GFCE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GFCE_ECOLI garnier swissprot:GFCE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GFCE_ECOLI helixturnhelix swissprot:GFCE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GFCE_ECOLI hmoment swissprot:GFCE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GFCE_ECOLI iep swissprot:GFCE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GFCE_ECOLI inforesidue swissprot:GFCE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GFCE_ECOLI octanol swissprot:GFCE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GFCE_ECOLI pepcoil swissprot:GFCE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GFCE_ECOLI pepdigest swissprot:GFCE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GFCE_ECOLI pepinfo swissprot:GFCE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GFCE_ECOLI pepnet swissprot:GFCE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GFCE_ECOLI pepstats swissprot:GFCE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GFCE_ECOLI pepwheel swissprot:GFCE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GFCE_ECOLI pepwindow swissprot:GFCE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GFCE_ECOLI sigcleave swissprot:GFCE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GFCE_ECOLI ## Database ID URL or Descriptions # AltName GLO2_ECOLI Glyoxalase II # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters KM=184 uM for S-D-lactoyl-glutathione; Vmax=122 umol/min/mg enzyme; # BRENDA 3.1.2 2026 # BioGrid 4262005 16 # CATALYTIC ACTIVITY GLO2_ECOLI S-(2-hydroxyacyl)glutathione + H(2)O = glutathione + a 2-hydroxy carboxylate. # COFACTOR GLO2_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 17196158}; Note=Binds 2 Zn(2+) ions per subunit. {ECO 0000269|PubMed 17196158}; # EcoGene EG13330 gloB # FUNCTION GLO2_ECOLI Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid. # GO_function GO:0004416 hydroxyacylglutathione hydrolase activity; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_process GO:0009408 response to heat; IMP:EcoCyc. # GO_process GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione; IDA:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.60.15.10 -; 1. # HAMAP MF_01374 Glyoxalase_2 # InterPro IPR001279 Metallo-B-lactamas # InterPro IPR017782 Hydroxyacylglutathione_Hdrlase # InterPro IPR032282 HAGH_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00620 Pyruvate metabolism # MASS SPECTROMETRY Mass=28432; Method=Electrospray; Range=1-251; Evidence={ECO:0000269|PubMed 17196158}; # MISCELLANEOUS GLO2_ECOLI Mn(2+) and Co(2+) can substitute for zinc in reconstitution experiments. # Organism GLO2_ECOLI Escherichia coli (strain K12) # PATHWAY Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal step 2/2. # PATRIC 32115537 VBIEscCol129921_0214 # PIR F64745 F64745 # PIRSF PIRSF005457 Glx # Pfam PF00753 Lactamase_B # Pfam PF16123 HAGH_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLO2_ECOLI Hydroxyacylglutathione hydrolase # RefSeq NP_414748 NC_000913.3 # RefSeq WP_001052715 NZ_LN832404.1 # SIMILARITY Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. {ECO 0000305}. # SMART SM00849 Lactamase_B # SUBUNIT Monomer. {ECO:0000269|PubMed 17196158}. # SUPFAM SSF56281 SSF56281 # TIGRFAMs TIGR03413 GSH_gloB # UniPathway UPA00619 UER00676 # eggNOG COG0491 LUCA # eggNOG ENOG4108RW0 Bacteria BLAST swissprot:GLO2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLO2_ECOLI BioCyc ECOL316407:JW0202-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0202-MONOMER BioCyc EcoCyc:GLYOXII-MONOMER http://biocyc.org/getid?id=EcoCyc:GLYOXII-MONOMER BioCyc MetaCyc:GLYOXII-MONOMER http://biocyc.org/getid?id=MetaCyc:GLYOXII-MONOMER COG COG0491 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0491 DIP DIP-48248N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48248N DOI 10.1016/j.abb.2006.11.024 http://dx.doi.org/10.1016/j.abb.2006.11.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.2.6 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.2.6 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 ENZYME 3.1.2.6 http://enzyme.expasy.org/EC/3.1.2.6 EchoBASE EB3114 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3114 EcoGene EG13330 http://www.ecogene.org/geneInfo.php?eg_id=EG13330 EnsemblBacteria AAC73317 http://www.ensemblgenomes.org/id/AAC73317 EnsemblBacteria AAC73317 http://www.ensemblgenomes.org/id/AAC73317 EnsemblBacteria BAA77883 http://www.ensemblgenomes.org/id/BAA77883 EnsemblBacteria BAA77883 http://www.ensemblgenomes.org/id/BAA77883 EnsemblBacteria BAA77883 http://www.ensemblgenomes.org/id/BAA77883 EnsemblBacteria b0212 http://www.ensemblgenomes.org/id/b0212 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004416 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004416 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GO_process GO:0019243 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019243 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.60.15.10 http://www.cathdb.info/version/latest/superfamily/3.60.15.10 GeneID 944902 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944902 HAMAP MF_01374 http://hamap.expasy.org/unirule/MF_01374 HOGENOM HOG000058041 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000058041&db=HOGENOM6 InParanoid P0AC84 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AC84 IntAct P0AC84 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AC84* IntEnz 3.1.2.6 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.2.6 InterPro IPR001279 http://www.ebi.ac.uk/interpro/entry/IPR001279 InterPro IPR017782 http://www.ebi.ac.uk/interpro/entry/IPR017782 InterPro IPR032282 http://www.ebi.ac.uk/interpro/entry/IPR032282 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0202 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0202 KEGG_Gene eco:b0212 http://www.genome.jp/dbget-bin/www_bget?eco:b0212 KEGG_Orthology KO:K01069 http://www.genome.jp/dbget-bin/www_bget?KO:K01069 KEGG_Pathway ko00620 http://www.genome.jp/kegg-bin/show_pathway?ko00620 KEGG_Reaction rn:R01736 http://www.genome.jp/dbget-bin/www_bget?rn:R01736 MINT MINT-1295781 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1295781 OMA DNYIFLL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DNYIFLL PSORT swissprot:GLO2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLO2_ECOLI PSORT-B swissprot:GLO2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLO2_ECOLI PSORT2 swissprot:GLO2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLO2_ECOLI Pfam PF00753 http://pfam.xfam.org/family/PF00753 Pfam PF16123 http://pfam.xfam.org/family/PF16123 Phobius swissprot:GLO2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLO2_ECOLI PhylomeDB P0AC84 http://phylomedb.org/?seqid=P0AC84 ProteinModelPortal P0AC84 http://www.proteinmodelportal.org/query/uniprot/P0AC84 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17196158 http://www.ncbi.nlm.nih.gov/pubmed/17196158 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414748 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414748 RefSeq WP_001052715 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001052715 SMART SM00849 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00849 SMR P0AC84 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AC84 STRING 511145.b0212 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0212&targetmode=cogs STRING COG0491 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0491&targetmode=cogs SUPFAM SSF56281 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56281 TIGRFAMs TIGR03413 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03413 UniProtKB GLO2_ECOLI http://www.uniprot.org/uniprot/GLO2_ECOLI UniProtKB-AC P0AC84 http://www.uniprot.org/uniprot/P0AC84 charge swissprot:GLO2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLO2_ECOLI eggNOG COG0491 http://eggnogapi.embl.de/nog_data/html/tree/COG0491 eggNOG ENOG4108RW0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108RW0 epestfind swissprot:GLO2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLO2_ECOLI garnier swissprot:GLO2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLO2_ECOLI helixturnhelix swissprot:GLO2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLO2_ECOLI hmoment swissprot:GLO2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLO2_ECOLI iep swissprot:GLO2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLO2_ECOLI inforesidue swissprot:GLO2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLO2_ECOLI octanol swissprot:GLO2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLO2_ECOLI pepcoil swissprot:GLO2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLO2_ECOLI pepdigest swissprot:GLO2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLO2_ECOLI pepinfo swissprot:GLO2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLO2_ECOLI pepnet swissprot:GLO2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLO2_ECOLI pepstats swissprot:GLO2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLO2_ECOLI pepwheel swissprot:GLO2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLO2_ECOLI pepwindow swissprot:GLO2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLO2_ECOLI sigcleave swissprot:GLO2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLO2_ECOLI ## Database ID URL or Descriptions # BioGrid 4259637 11 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG12501 ytfA # GO_function GO:0003677 DNA binding; IEA:InterPro. # GOslim_function GO:0003677 DNA binding # Gene3D 1.10.357.10 -; 1. # InterPro IPR011075 Tet_transcr_reg_TetR-rel_C # InterPro IPR015893 Tet_transcr_reg_TetR-like_C # Organism YTFA_ECOLI Escherichia coli (strain K12) # PATRIC 48667980 VBIEscCol107702_4243 # PIR S56430 S56430 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YTFA_ECOLI Putative uncharacterized protein YtfA # SUPFAM SSF48498 SSF48498 # eggNOG ENOG4111WFN LUCA BLAST swissprot:YTFA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YTFA_ECOLI BioCyc ECOL316407:JW4163-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4163-MONOMER BioCyc EcoCyc:G7863-MONOMER http://biocyc.org/getid?id=EcoCyc:G7863-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2394 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2394 EcoGene EG12501 http://www.ecogene.org/geneInfo.php?eg_id=EG12501 EnsemblBacteria BAE78206 http://www.ensemblgenomes.org/id/BAE78206 EnsemblBacteria BAE78206 http://www.ensemblgenomes.org/id/BAE78206 EnsemblBacteria BAE78206 http://www.ensemblgenomes.org/id/BAE78206 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 Gene3D 1.10.357.10 http://www.cathdb.info/version/latest/superfamily/1.10.357.10 HOGENOM HOG000161261 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000161261&db=HOGENOM6 InterPro IPR011075 http://www.ebi.ac.uk/interpro/entry/IPR011075 InterPro IPR015893 http://www.ebi.ac.uk/interpro/entry/IPR015893 KEGG_Gene ecj:JW4163 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4163 OMA YHISMIS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YHISMIS PSORT swissprot:YTFA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YTFA_ECOLI PSORT-B swissprot:YTFA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YTFA_ECOLI PSORT2 swissprot:YTFA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YTFA_ECOLI Phobius swissprot:YTFA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YTFA_ECOLI PhylomeDB P39309 http://phylomedb.org/?seqid=P39309 ProteinModelPortal P39309 http://www.proteinmodelportal.org/query/uniprot/P39309 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 STRING 316407.85676956 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85676956&targetmode=cogs SUPFAM SSF48498 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48498 UniProtKB YTFA_ECOLI http://www.uniprot.org/uniprot/YTFA_ECOLI UniProtKB-AC P39309 http://www.uniprot.org/uniprot/P39309 charge swissprot:YTFA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YTFA_ECOLI eggNOG ENOG4111WFN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111WFN epestfind swissprot:YTFA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YTFA_ECOLI garnier swissprot:YTFA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YTFA_ECOLI helixturnhelix swissprot:YTFA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YTFA_ECOLI hmoment swissprot:YTFA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YTFA_ECOLI iep swissprot:YTFA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YTFA_ECOLI inforesidue swissprot:YTFA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YTFA_ECOLI octanol swissprot:YTFA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YTFA_ECOLI pepcoil swissprot:YTFA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YTFA_ECOLI pepdigest swissprot:YTFA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YTFA_ECOLI pepinfo swissprot:YTFA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YTFA_ECOLI pepnet swissprot:YTFA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YTFA_ECOLI pepstats swissprot:YTFA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YTFA_ECOLI pepwheel swissprot:YTFA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YTFA_ECOLI pepwindow swissprot:YTFA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YTFA_ECOLI sigcleave swissprot:YTFA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YTFA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261528 9 # EcoGene EG13585 ykgH # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # Organism YKGH_ECOLI Escherichia coli (strain K12) # PATRIC 32115749 VBIEscCol129921_0317 # PIR F64757 F64757 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YKGH_ECOLI Uncharacterized protein YkgH # RefSeq NP_414844 NC_000913.3 # RefSeq WP_001209100 NZ_LN832404.1 # SUBCELLULAR LOCATION YKGH_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. BLAST swissprot:YKGH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YKGH_ECOLI BioCyc ECOL316407:JW0302-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0302-MONOMER BioCyc EcoCyc:G6180-MONOMER http://biocyc.org/getid?id=EcoCyc:G6180-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB3355 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3355 EcoGene EG13585 http://www.ecogene.org/geneInfo.php?eg_id=EG13585 EnsemblBacteria AAC73413 http://www.ensemblgenomes.org/id/AAC73413 EnsemblBacteria AAC73413 http://www.ensemblgenomes.org/id/AAC73413 EnsemblBacteria BAE76093 http://www.ensemblgenomes.org/id/BAE76093 EnsemblBacteria BAE76093 http://www.ensemblgenomes.org/id/BAE76093 EnsemblBacteria BAE76093 http://www.ensemblgenomes.org/id/BAE76093 EnsemblBacteria b0310 http://www.ensemblgenomes.org/id/b0310 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 947513 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947513 HOGENOM HOG000117279 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117279&db=HOGENOM6 KEGG_Gene ecj:JW0302 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0302 KEGG_Gene eco:b0310 http://www.genome.jp/dbget-bin/www_bget?eco:b0310 OMA RVHASII http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RVHASII PSORT swissprot:YKGH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YKGH_ECOLI PSORT-B swissprot:YKGH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YKGH_ECOLI PSORT2 swissprot:YKGH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YKGH_ECOLI Phobius swissprot:YKGH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YKGH_ECOLI ProteinModelPortal P77180 http://www.proteinmodelportal.org/query/uniprot/P77180 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414844 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414844 RefSeq WP_001209100 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001209100 STRING 511145.b0310 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0310&targetmode=cogs UniProtKB YKGH_ECOLI http://www.uniprot.org/uniprot/YKGH_ECOLI UniProtKB-AC P77180 http://www.uniprot.org/uniprot/P77180 charge swissprot:YKGH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YKGH_ECOLI epestfind swissprot:YKGH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YKGH_ECOLI garnier swissprot:YKGH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YKGH_ECOLI helixturnhelix swissprot:YKGH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YKGH_ECOLI hmoment swissprot:YKGH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YKGH_ECOLI iep swissprot:YKGH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YKGH_ECOLI inforesidue swissprot:YKGH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YKGH_ECOLI octanol swissprot:YKGH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YKGH_ECOLI pepcoil swissprot:YKGH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YKGH_ECOLI pepdigest swissprot:YKGH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YKGH_ECOLI pepinfo swissprot:YKGH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YKGH_ECOLI pepnet swissprot:YKGH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YKGH_ECOLI pepstats swissprot:YKGH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YKGH_ECOLI pepwheel swissprot:YKGH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YKGH_ECOLI pepwindow swissprot:YKGH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YKGH_ECOLI sigcleave swissprot:YKGH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YKGH_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=0.48 mM for L-rhamnulose 1-phosphate (at 37 degrees Celsius) {ECO 0000269|PubMed:12962479}; # BRENDA 4.1.2.19 2026 # CATALYTIC ACTIVITY L-rhamnulose 1-phosphate = glycerone phosphate + (S)-lactaldehyde. {ECO:0000269|PubMed 12962479}. # COFACTOR RHAD_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 11976494, ECO 0000269|PubMed 12962479}; Note=Binds 1 zinc ion per subunit. {ECO 0000269|PubMed 11976494, ECO 0000269|PubMed 12962479}; # EcoGene EG11866 rhaD # FUNCTION RHAD_ECOLI Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (PubMed 12962479). Also catalyzes the dephosphorylation of phospho-serine in vitro (PubMed 25848029). {ECO 0000269|PubMed 12962479, ECO 0000269|PubMed 25848029}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0008994 rhamnulose-1-phosphate aldolase activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0019301 rhamnose catabolic process; IMP:EcoCyc. # GO_process GO:0019323 pentose catabolic process; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.225.10 -; 1. # HAMAP MF_00770 RhaD # INDUCTION RHAD_ECOLI Induced by L-rhamnose via the RhaR-RhaS regulatory cascade. Binding of the cAMP receptor protein (CRP) is required for full expression. {ECO 0000269|PubMed 10852886, ECO 0000269|PubMed 8230210}. # IntAct P32169 7 # InterPro IPR001303 Aldolase_II/adducin_N # InterPro IPR013447 Rhamnulose-1-P_Aldolase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00040 Pentose and glucuronate interconversions # KEGG_Pathway ko00051 Fructose and mannose metabolism # Organism RHAD_ECOLI Escherichia coli (strain K12) # PATHWAY Carbohydrate degradation; L-rhamnose degradation; glycerone phosphate from L-rhamnose step 3/3. # PATRIC 32123313 VBIEscCol129921_4017 # PDB 1GT7 X-ray; 2.70 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T=1-274 # PDB 1OJR X-ray; 1.35 A; A=1-274 # PDB 2UYU X-ray; 1.96 A; A/E=1-274 # PDB 2UYV X-ray; 2.20 A; A/B/C/D=1-274 # PDB 2V29 X-ray; 2.03 A; A/B=1-274 # PDB 2V2A X-ray; 1.75 A; A=1-274 # PDB 2V2B X-ray; 1.50 A; A=1-274 # PDB 2V9E X-ray; 1.58 A; A/B=1-272 # PDB 2V9F X-ray; 2.10 A; A=1-272 # PDB 2V9G X-ray; 2.70 A; A/B/C/D=1-274 # PDB 2V9I X-ray; 1.80 A; A/B=1-273 # PDB 2V9L X-ray; 1.23 A; A=1-274 # PDB 2V9M X-ray; 1.30 A; A/B=1-274 # PDB 2V9N X-ray; 1.40 A; A/B/C/D=1-274 # PDB 2V9O X-ray; 1.95 A; A/E=1-274 # PIR C48649 C48649 # Pfam PF00596 Aldolase_II # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RHAD_ECOLI Rhamnulose-1-phosphate aldolase # RefSeq NP_418338 NC_000913.3 # RefSeq WP_001179745 NZ_LN832404.1 # SIMILARITY Belongs to the aldolase class II family. RhaD subfamily. {ECO 0000305}. # SMART SM01007 Aldolase_II # SUBCELLULAR LOCATION RHAD_ECOLI Cytoplasm. # SUBUNIT Homotetramer. {ECO:0000269|PubMed 11976494}. # SUPFAM SSF53639 SSF53639 # TIGRFAMs TIGR02624 rhamnu_1P_ald # UniPathway UPA00541 UER00603 # eggNOG COG0235 LUCA # eggNOG ENOG4105C9J Bacteria BLAST swissprot:RHAD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RHAD_ECOLI BioCyc ECOL316407:JW3873-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3873-MONOMER BioCyc EcoCyc:RHAMNULPALDOL-MONOMER http://biocyc.org/getid?id=EcoCyc:RHAMNULPALDOL-MONOMER BioCyc MetaCyc:RHAMNULPALDOL-MONOMER http://biocyc.org/getid?id=MetaCyc:RHAMNULPALDOL-MONOMER COG COG0235 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0235 DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/jmbi.1993.1565 http://dx.doi.org/10.1006/jmbi.1993.1565 DOI 10.1021/bi0349266 http://dx.doi.org/10.1021/bi0349266 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.1423570112 http://dx.doi.org/10.1073/pnas.1423570112 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1107/S0907444902004614 http://dx.doi.org/10.1107/S0907444902004614 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.12.3529-3535.2000 http://dx.doi.org/10.1128/JB.182.12.3529-3535.2000 EC_number EC:4.1.2.19 {ECO:0000269|PubMed:12962479} http://www.genome.jp/dbget-bin/www_bget?EC:4.1.2.19 {ECO:0000269|PubMed:12962479} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X60472 http://www.ebi.ac.uk/ena/data/view/X60472 ENZYME 4.1.2.19 {ECO:0000269|PubMed:12962479} http://enzyme.expasy.org/EC/4.1.2.19 {ECO:0000269|PubMed:12962479} EchoBASE EB1812 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1812 EcoGene EG11866 http://www.ecogene.org/geneInfo.php?eg_id=EG11866 EnsemblBacteria AAC76884 http://www.ensemblgenomes.org/id/AAC76884 EnsemblBacteria AAC76884 http://www.ensemblgenomes.org/id/AAC76884 EnsemblBacteria BAE77407 http://www.ensemblgenomes.org/id/BAE77407 EnsemblBacteria BAE77407 http://www.ensemblgenomes.org/id/BAE77407 EnsemblBacteria BAE77407 http://www.ensemblgenomes.org/id/BAE77407 EnsemblBacteria b3902 http://www.ensemblgenomes.org/id/b3902 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008994 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008994 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0019301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019301 GO_process GO:0019323 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019323 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.225.10 http://www.cathdb.info/version/latest/superfamily/3.40.225.10 GeneID 948401 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948401 HAMAP MF_00770 http://hamap.expasy.org/unirule/MF_00770 HOGENOM HOG000279628 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000279628&db=HOGENOM6 InParanoid P32169 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32169 IntAct P32169 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32169* IntEnz 4.1.2.19 {ECO:0000269|PubMed:12962479} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.2.19 {ECO:0000269|PubMed:12962479} InterPro IPR001303 http://www.ebi.ac.uk/interpro/entry/IPR001303 InterPro IPR013447 http://www.ebi.ac.uk/interpro/entry/IPR013447 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3873 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3873 KEGG_Gene eco:b3902 http://www.genome.jp/dbget-bin/www_bget?eco:b3902 KEGG_Orthology KO:K01629 http://www.genome.jp/dbget-bin/www_bget?KO:K01629 KEGG_Pathway ko00040 http://www.genome.jp/kegg-bin/show_pathway?ko00040 KEGG_Pathway ko00051 http://www.genome.jp/kegg-bin/show_pathway?ko00051 KEGG_Reaction rn:R01785 http://www.genome.jp/dbget-bin/www_bget?rn:R01785 KEGG_Reaction rn:R02263 http://www.genome.jp/dbget-bin/www_bget?rn:R02263 OMA SHFMSHI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SHFMSHI PDB 1GT7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1GT7 PDB 1OJR http://www.ebi.ac.uk/pdbe-srv/view/entry/1OJR PDB 2UYU http://www.ebi.ac.uk/pdbe-srv/view/entry/2UYU PDB 2UYV http://www.ebi.ac.uk/pdbe-srv/view/entry/2UYV PDB 2V29 http://www.ebi.ac.uk/pdbe-srv/view/entry/2V29 PDB 2V2A http://www.ebi.ac.uk/pdbe-srv/view/entry/2V2A PDB 2V2B http://www.ebi.ac.uk/pdbe-srv/view/entry/2V2B PDB 2V9E http://www.ebi.ac.uk/pdbe-srv/view/entry/2V9E PDB 2V9F http://www.ebi.ac.uk/pdbe-srv/view/entry/2V9F PDB 2V9G http://www.ebi.ac.uk/pdbe-srv/view/entry/2V9G PDB 2V9I http://www.ebi.ac.uk/pdbe-srv/view/entry/2V9I PDB 2V9L http://www.ebi.ac.uk/pdbe-srv/view/entry/2V9L PDB 2V9M http://www.ebi.ac.uk/pdbe-srv/view/entry/2V9M PDB 2V9N http://www.ebi.ac.uk/pdbe-srv/view/entry/2V9N PDB 2V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/2V9O PDBsum 1GT7 http://www.ebi.ac.uk/pdbsum/1GT7 PDBsum 1OJR http://www.ebi.ac.uk/pdbsum/1OJR PDBsum 2UYU http://www.ebi.ac.uk/pdbsum/2UYU PDBsum 2UYV http://www.ebi.ac.uk/pdbsum/2UYV PDBsum 2V29 http://www.ebi.ac.uk/pdbsum/2V29 PDBsum 2V2A http://www.ebi.ac.uk/pdbsum/2V2A PDBsum 2V2B http://www.ebi.ac.uk/pdbsum/2V2B PDBsum 2V9E http://www.ebi.ac.uk/pdbsum/2V9E PDBsum 2V9F http://www.ebi.ac.uk/pdbsum/2V9F PDBsum 2V9G http://www.ebi.ac.uk/pdbsum/2V9G PDBsum 2V9I http://www.ebi.ac.uk/pdbsum/2V9I PDBsum 2V9L http://www.ebi.ac.uk/pdbsum/2V9L PDBsum 2V9M http://www.ebi.ac.uk/pdbsum/2V9M PDBsum 2V9N http://www.ebi.ac.uk/pdbsum/2V9N PDBsum 2V9O http://www.ebi.ac.uk/pdbsum/2V9O PSORT swissprot:RHAD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RHAD_ECOLI PSORT-B swissprot:RHAD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RHAD_ECOLI PSORT2 swissprot:RHAD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RHAD_ECOLI Pfam PF00596 http://pfam.xfam.org/family/PF00596 Phobius swissprot:RHAD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RHAD_ECOLI PhylomeDB P32169 http://phylomedb.org/?seqid=P32169 ProteinModelPortal P32169 http://www.proteinmodelportal.org/query/uniprot/P32169 PubMed 10852886 http://www.ncbi.nlm.nih.gov/pubmed/10852886 PubMed 11976494 http://www.ncbi.nlm.nih.gov/pubmed/11976494 PubMed 12962479 http://www.ncbi.nlm.nih.gov/pubmed/12962479 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 25848029 http://www.ncbi.nlm.nih.gov/pubmed/25848029 PubMed 8230210 http://www.ncbi.nlm.nih.gov/pubmed/8230210 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 8396120 http://www.ncbi.nlm.nih.gov/pubmed/8396120 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_418338 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418338 RefSeq WP_001179745 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001179745 SMART SM01007 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01007 SMR P32169 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32169 STRING 511145.b3902 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3902&targetmode=cogs STRING COG0235 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0235&targetmode=cogs SUPFAM SSF53639 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53639 TIGRFAMs TIGR02624 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02624 UniProtKB RHAD_ECOLI http://www.uniprot.org/uniprot/RHAD_ECOLI UniProtKB-AC P32169 http://www.uniprot.org/uniprot/P32169 charge swissprot:RHAD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RHAD_ECOLI eggNOG COG0235 http://eggnogapi.embl.de/nog_data/html/tree/COG0235 eggNOG ENOG4105C9J http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C9J epestfind swissprot:RHAD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RHAD_ECOLI garnier swissprot:RHAD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RHAD_ECOLI helixturnhelix swissprot:RHAD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RHAD_ECOLI hmoment swissprot:RHAD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RHAD_ECOLI iep swissprot:RHAD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RHAD_ECOLI inforesidue swissprot:RHAD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RHAD_ECOLI octanol swissprot:RHAD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RHAD_ECOLI pepcoil swissprot:RHAD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RHAD_ECOLI pepdigest swissprot:RHAD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RHAD_ECOLI pepinfo swissprot:RHAD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RHAD_ECOLI pepnet swissprot:RHAD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RHAD_ECOLI pepstats swissprot:RHAD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RHAD_ECOLI pepwheel swissprot:RHAD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RHAD_ECOLI pepwindow swissprot:RHAD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RHAD_ECOLI sigcleave swissprot:RHAD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RHAD_ECOLI ## Database ID URL or Descriptions # BioGrid 4259372 9 # EcoGene EG14319 ysaA # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0016491 oxidoreductase activity; IBA:GO_Central. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # IntAct P56256 2 # InterPro IPR017896 4Fe4S_Fe-S-bd # InterPro IPR017900 4Fe4S_Fe_S_CS # Organism YSAA_ECOLI Escherichia coli (strain K12) # PATRIC 32122622 VBIEscCol129921_3688 # PIR G65156 G65156 # PROSITE PS00198 4FE4S_FER_1 # PROSITE PS51379 4FE4S_FER_2; 4 # Pfam PF13247 Fer4_11 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YSAA_ECOLI Putative electron transport protein YsaA # RefSeq NP_418030 NC_000913.3 # RefSeq WP_001300918 NZ_LN832404.1 # SIMILARITY Contains 4 4Fe-4S ferredoxin-type domains. {ECO:0000255|PROSITE-ProRule PRU00711}. # eggNOG COG1142 LUCA # eggNOG ENOG4108XIB Bacteria BLAST swissprot:YSAA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YSAA_ECOLI BioCyc ECOL316407:JW3545-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3545-MONOMER BioCyc EcoCyc:EG12277-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12277-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4065 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4065 EcoGene EG14319 http://www.ecogene.org/geneInfo.php?eg_id=EG14319 EnsemblBacteria AAC76597 http://www.ensemblgenomes.org/id/AAC76597 EnsemblBacteria AAC76597 http://www.ensemblgenomes.org/id/AAC76597 EnsemblBacteria BAE77720 http://www.ensemblgenomes.org/id/BAE77720 EnsemblBacteria BAE77720 http://www.ensemblgenomes.org/id/BAE77720 EnsemblBacteria BAE77720 http://www.ensemblgenomes.org/id/BAE77720 EnsemblBacteria b3573 http://www.ensemblgenomes.org/id/b3573 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GeneID 948085 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948085 HOGENOM HOG000163385 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000163385&db=HOGENOM6 InParanoid P56256 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P56256 IntAct P56256 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P56256* InterPro IPR017896 http://www.ebi.ac.uk/interpro/entry/IPR017896 InterPro IPR017900 http://www.ebi.ac.uk/interpro/entry/IPR017900 KEGG_Gene ecj:JW3545 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3545 KEGG_Gene eco:b3573 http://www.genome.jp/dbget-bin/www_bget?eco:b3573 OMA NIPWQCR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NIPWQCR PROSITE PS00198 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00198 PROSITE PS51379 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51379 PSORT swissprot:YSAA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YSAA_ECOLI PSORT-B swissprot:YSAA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YSAA_ECOLI PSORT2 swissprot:YSAA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YSAA_ECOLI Pfam PF13247 http://pfam.xfam.org/family/PF13247 Phobius swissprot:YSAA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YSAA_ECOLI PhylomeDB P56256 http://phylomedb.org/?seqid=P56256 ProteinModelPortal P56256 http://www.proteinmodelportal.org/query/uniprot/P56256 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418030 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418030 RefSeq WP_001300918 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300918 SMR P56256 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P56256 STRING 511145.b3573 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3573&targetmode=cogs UniProtKB YSAA_ECOLI http://www.uniprot.org/uniprot/YSAA_ECOLI UniProtKB-AC P56256 http://www.uniprot.org/uniprot/P56256 charge swissprot:YSAA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YSAA_ECOLI eggNOG COG1142 http://eggnogapi.embl.de/nog_data/html/tree/COG1142 eggNOG ENOG4108XIB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108XIB epestfind swissprot:YSAA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YSAA_ECOLI garnier swissprot:YSAA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YSAA_ECOLI helixturnhelix swissprot:YSAA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YSAA_ECOLI hmoment swissprot:YSAA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YSAA_ECOLI iep swissprot:YSAA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YSAA_ECOLI inforesidue swissprot:YSAA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YSAA_ECOLI octanol swissprot:YSAA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YSAA_ECOLI pepcoil swissprot:YSAA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YSAA_ECOLI pepdigest swissprot:YSAA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YSAA_ECOLI pepinfo swissprot:YSAA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YSAA_ECOLI pepnet swissprot:YSAA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YSAA_ECOLI pepstats swissprot:YSAA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YSAA_ECOLI pepwheel swissprot:YSAA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YSAA_ECOLI pepwindow swissprot:YSAA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YSAA_ECOLI sigcleave swissprot:YSAA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YSAA_ECOLI ## Database ID URL or Descriptions # AltName ARCA_ECOLI Dye resistance protein # BioGrid 4259386 13 # CDD cd00383 trans_reg_C # EcoGene EG10061 arcA # FUNCTION ARCA_ECOLI Member of the two-component regulatory system ArcB/ArcA. Represses a wide variety of aerobic enzymes under anaerobic conditions. Controls the resistance of E.coli to dyes; required for expression of the alkaline phosphatase and sex factor F genes; It also may be involved in the osmoregulation of envelope proteins. When activated by ArcB, it negatively regulates the expression of genes of aerobic function. Activates the transcription of the plfB operon by binding to its promoter. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000156 phosphorelay response regulator activity; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0000160 phosphorelay signal transduction system; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004871 signal transducer activity # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # INTERACTION ARCA_ECOLI Self; NbExp=2; IntAct=EBI-1119939, EBI-1119939; P52002 mexB (xeno); NbExp=2; IntAct=EBI-1119939, EBI-6400435; # IntAct P0A9Q1 7 # InterPro IPR001789 Sig_transdc_resp-reg_receiver # InterPro IPR001867 OmpR/PhoB-type_DNA-bd # InterPro IPR011006 CheY-like_superfamily # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR016032 Sig_transdc_resp-reg_C-effctor # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02022 M00456 ArcB-ArcA (anoxic redox control) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # Organism ARCA_ECOLI Escherichia coli (strain K12) # PATRIC 32124420 VBIEscCol129921_4550 # PDB 1XHE X-ray; 2.50 A; A/B=1-123 # PDB 1XHF X-ray; 2.15 A; A/B=1-123 # PIR A03561 JYECR # PROSITE PS50110 RESPONSE_REGULATORY # PROSITE PS51755 OMPR_PHOB # PTM ARCA_ECOLI Phosphorylated by ArcB. # Pfam PF00072 Response_reg # Pfam PF00486 Trans_reg_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ARCA_ECOLI Aerobic respiration control protein ArcA # RefSeq NP_418818 NC_000913.3 # RefSeq WP_001194358 NZ_LN832404.1 # SIMILARITY Contains 1 OmpR/PhoB-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU01091}. # SIMILARITY Contains 1 response regulatory domain. {ECO:0000255|PROSITE-ProRule PRU00169}. # SMART SM00448 REC # SMART SM00862 Trans_reg_C # SUBCELLULAR LOCATION ARCA_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF46894 SSF46894 # SUPFAM SSF52172 SSF52172 # eggNOG COG0745 LUCA # eggNOG ENOG41065U4 Bacteria BLAST swissprot:ARCA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARCA_ECOLI BioCyc ECOL316407:JW4364-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4364-MONOMER BioCyc EcoCyc:ARCA-MONOMER http://biocyc.org/getid?id=EcoCyc:ARCA-MONOMER COG COG0745 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0745 DIP DIP-36035N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36035N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1111/j.1365-2958.1995.tb02422.x http://dx.doi.org/10.1111/j.1365-2958.1995.tb02422.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L34010 http://www.ebi.ac.uk/ena/data/view/L34010 EMBL M10044 http://www.ebi.ac.uk/ena/data/view/M10044 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB0059 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0059 EcoGene EG10061 http://www.ecogene.org/geneInfo.php?eg_id=EG10061 EnsemblBacteria AAC77354 http://www.ensemblgenomes.org/id/AAC77354 EnsemblBacteria AAC77354 http://www.ensemblgenomes.org/id/AAC77354 EnsemblBacteria BAE78390 http://www.ensemblgenomes.org/id/BAE78390 EnsemblBacteria BAE78390 http://www.ensemblgenomes.org/id/BAE78390 EnsemblBacteria BAE78390 http://www.ensemblgenomes.org/id/BAE78390 EnsemblBacteria b4401 http://www.ensemblgenomes.org/id/b4401 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000156 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000156 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 948874 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948874 HOGENOM HOG000034819 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000034819&db=HOGENOM6 InParanoid P0A9Q1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9Q1 IntAct P0A9Q1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9Q1* InterPro IPR001789 http://www.ebi.ac.uk/interpro/entry/IPR001789 InterPro IPR001867 http://www.ebi.ac.uk/interpro/entry/IPR001867 InterPro IPR011006 http://www.ebi.ac.uk/interpro/entry/IPR011006 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR016032 http://www.ebi.ac.uk/interpro/entry/IPR016032 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW4364 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4364 KEGG_Gene eco:b4401 http://www.genome.jp/dbget-bin/www_bget?eco:b4401 KEGG_Orthology KO:K07773 http://www.genome.jp/dbget-bin/www_bget?KO:K07773 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA FLECEGF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FLECEGF PDB 1XHE http://www.ebi.ac.uk/pdbe-srv/view/entry/1XHE PDB 1XHF http://www.ebi.ac.uk/pdbe-srv/view/entry/1XHF PDBsum 1XHE http://www.ebi.ac.uk/pdbsum/1XHE PDBsum 1XHF http://www.ebi.ac.uk/pdbsum/1XHF PROSITE PS50110 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50110 PROSITE PS51755 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51755 PSORT swissprot:ARCA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARCA_ECOLI PSORT-B swissprot:ARCA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARCA_ECOLI PSORT2 swissprot:ARCA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARCA_ECOLI Pfam PF00072 http://pfam.xfam.org/family/PF00072 Pfam PF00486 http://pfam.xfam.org/family/PF00486 Phobius swissprot:ARCA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARCA_ECOLI PhylomeDB P0A9Q1 http://phylomedb.org/?seqid=P0A9Q1 ProteinModelPortal P0A9Q1 http://www.proteinmodelportal.org/query/uniprot/P0A9Q1 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2984198 http://www.ncbi.nlm.nih.gov/pubmed/2984198 PubMed 7565118 http://www.ncbi.nlm.nih.gov/pubmed/7565118 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_418818 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418818 RefSeq WP_001194358 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001194358 SMART SM00448 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00448 SMART SM00862 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00862 SMR P0A9Q1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9Q1 STRING 511145.b4401 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4401&targetmode=cogs STRING COG0745 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0745&targetmode=cogs SUPFAM SSF46894 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46894 SUPFAM SSF52172 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52172 SWISS-2DPAGE P0A9Q1 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A9Q1 UniProtKB ARCA_ECOLI http://www.uniprot.org/uniprot/ARCA_ECOLI UniProtKB-AC P0A9Q1 http://www.uniprot.org/uniprot/P0A9Q1 charge swissprot:ARCA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARCA_ECOLI eggNOG COG0745 http://eggnogapi.embl.de/nog_data/html/tree/COG0745 eggNOG ENOG41065U4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41065U4 epestfind swissprot:ARCA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARCA_ECOLI garnier swissprot:ARCA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARCA_ECOLI helixturnhelix swissprot:ARCA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARCA_ECOLI hmoment swissprot:ARCA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARCA_ECOLI iep swissprot:ARCA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARCA_ECOLI inforesidue swissprot:ARCA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARCA_ECOLI octanol swissprot:ARCA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARCA_ECOLI pepcoil swissprot:ARCA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARCA_ECOLI pepdigest swissprot:ARCA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARCA_ECOLI pepinfo swissprot:ARCA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARCA_ECOLI pepnet swissprot:ARCA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARCA_ECOLI pepstats swissprot:ARCA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARCA_ECOLI pepwheel swissprot:ARCA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARCA_ECOLI pepwindow swissprot:ARCA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARCA_ECOLI sigcleave swissprot:ARCA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARCA_ECOLI ## Database ID URL or Descriptions # AltName BSMA_ECOLI Biofilm stress and motility protein # BioGrid 4263355 8 # DISRUPTION PHENOTYPE Mutant exhibits reduced microcolony formation and greatly enhanced flagellar motility. Biofilms from the mutant strain are less able to resist acid and peroxide stresses. {ECO:0000269|PubMed 19833773}. # EcoGene EG12489 bsmA # FUNCTION BSMA_ECOLI Involved in protection of biofilms against oxidative stress. {ECO 0000269|PubMed 19833773}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0042542 response to hydrogen peroxide; IMP:EcoCyc. # GO_process GO:0044010 single-species biofilm formation; IEP:EcoCyc. # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # Gene3D 3.30.1660.10 -; 1. # INDUCTION Up-regulated in biofilms. {ECO:0000269|PubMed 19833773}. # InterPro IPR010854 DUF1471 # InterPro IPR025543 Dodecin-like # Organism BSMA_ECOLI Escherichia coli (strain K12) # PATRIC 32123953 VBIEscCol129921_4321 # PIR S56414 S56414 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF07338 DUF1471 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BSMA_ECOLI Lipoprotein BsmA # RefSeq NP_418610 NC_000913.3 # RefSeq WP_000254633 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97085.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the BhsA/McbA family. {ECO 0000305}. # SUBCELLULAR LOCATION BSMA_ECOLI Cell membrane {ECO 0000255|PROSITE- ProRule PRU00303}; Lipid-anchor {ECO 0000255|PROSITE- ProRule PRU00303}. # SUPFAM SSF159871 SSF159871 # eggNOG ENOG4105WSB Bacteria # eggNOG ENOG41123U1 LUCA BLAST swissprot:BSMA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BSMA_ECOLI BioCyc ECOL316407:JW5743-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5743-MONOMER BioCyc EcoCyc:G7852-MONOMER http://biocyc.org/getid?id=EcoCyc:G7852-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1099/mic.0.031468-0 http://dx.doi.org/10.1099/mic.0.031468-0 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2382 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2382 EcoGene EG12489 http://www.ecogene.org/geneInfo.php?eg_id=EG12489 EnsemblBacteria AAC77146 http://www.ensemblgenomes.org/id/AAC77146 EnsemblBacteria AAC77146 http://www.ensemblgenomes.org/id/AAC77146 EnsemblBacteria BAE78190 http://www.ensemblgenomes.org/id/BAE78190 EnsemblBacteria BAE78190 http://www.ensemblgenomes.org/id/BAE78190 EnsemblBacteria BAE78190 http://www.ensemblgenomes.org/id/BAE78190 EnsemblBacteria b4189 http://www.ensemblgenomes.org/id/b4189 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0042542 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042542 GO_process GO:0044010 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044010 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.30.1660.10 http://www.cathdb.info/version/latest/superfamily/3.30.1660.10 GeneID 948708 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948708 HOGENOM HOG000127364 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000127364&db=HOGENOM6 InterPro IPR010854 http://www.ebi.ac.uk/interpro/entry/IPR010854 InterPro IPR025543 http://www.ebi.ac.uk/interpro/entry/IPR025543 KEGG_Gene ecj:JW5743 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5743 KEGG_Gene eco:b4189 http://www.genome.jp/dbget-bin/www_bget?eco:b4189 OMA PGQWYSQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PGQWYSQ PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:BSMA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BSMA_ECOLI PSORT-B swissprot:BSMA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BSMA_ECOLI PSORT2 swissprot:BSMA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BSMA_ECOLI Pfam PF07338 http://pfam.xfam.org/family/PF07338 Phobius swissprot:BSMA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BSMA_ECOLI ProteinModelPortal P39297 http://www.proteinmodelportal.org/query/uniprot/P39297 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19833773 http://www.ncbi.nlm.nih.gov/pubmed/19833773 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418610 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418610 RefSeq WP_000254633 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000254633 STRING 511145.b4189 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4189&targetmode=cogs SUPFAM SSF159871 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF159871 UniProtKB BSMA_ECOLI http://www.uniprot.org/uniprot/BSMA_ECOLI UniProtKB-AC P39297 http://www.uniprot.org/uniprot/P39297 charge swissprot:BSMA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BSMA_ECOLI eggNOG ENOG4105WSB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105WSB eggNOG ENOG41123U1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41123U1 epestfind swissprot:BSMA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BSMA_ECOLI garnier swissprot:BSMA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BSMA_ECOLI helixturnhelix swissprot:BSMA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BSMA_ECOLI hmoment swissprot:BSMA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BSMA_ECOLI iep swissprot:BSMA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BSMA_ECOLI inforesidue swissprot:BSMA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BSMA_ECOLI octanol swissprot:BSMA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BSMA_ECOLI pepcoil swissprot:BSMA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BSMA_ECOLI pepdigest swissprot:BSMA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BSMA_ECOLI pepinfo swissprot:BSMA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BSMA_ECOLI pepnet swissprot:BSMA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BSMA_ECOLI pepstats swissprot:BSMA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BSMA_ECOLI pepwheel swissprot:BSMA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BSMA_ECOLI pepwindow swissprot:BSMA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BSMA_ECOLI sigcleave swissprot:BSMA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BSMA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260855 262 # CATALYTIC ACTIVITY BCSA_ECOLI UDP-glucose + (1,4-beta-D-glucosyl)(n) = UDP + (1,4-beta-D-glucosyl)(n+1). # CAZy GT2 Glycosyltransferase Family 2 # COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI 18420; Evidence={ECO:0000250}; # DOMAIN BCSA_ECOLI There are two conserved domains in the globular part of the protein the N-terminal domain (domain A) contains the conserved DXD motif and is possibly involved in catalysis and substrate binding. The C-terminal domain (domain B) contains the QXXRW motif and is present only in processive glycosyl transferases. It could be involved in the processivity function of the enzyme, possibly required for holding the growing glycan chain in the active site. # ENZYME REGULATION BCSA_ECOLI Activated by bis-(3'-5') cyclic diguanylic acid (c-di-GMP). # EcoGene EG12260 bcsA # FUNCTION BCSA_ECOLI Catalytic subunit of cellulose synthase. It polymerizes uridine 5'-diphosphate glucose to cellulose, which is produced as an extracellular component for mechanical and chemical protection at the onset of the stationary phase, when the cells exhibit multicellular behavior (rdar morphotype). Coexpression of cellulose and thin aggregative fimbriae leads to a hydrophobic network with tightly packed cells embedded in a highly inert matrix. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0016758 transferase activity, transferring hexosyl groups; IBA:GO_Central. # GO_function GO:0016760 cellulose synthase (UDP-forming) activity; IEA:UniProtKB-EC. # GO_function GO:0035438 cyclic-di-GMP binding; IEA:InterPro. # GO_process GO:0006011 UDP-glucose metabolic process; IEA:InterPro. # GO_process GO:0090540 bacterial cellulose biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.90.550.10 -; 1. # IntAct P37653 3 # InterPro IPR001173 Glyco_trans_2-like # InterPro IPR003919 Cell_synth_A # InterPro IPR005150 Cellulose_synth # InterPro IPR009875 PilZ_domain # InterPro IPR029044 Nucleotide-diphossugar_trans # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01003 Glycosyltransferases # KEGG_Pathway ko00500 Starch and sucrose metabolism # MISCELLANEOUS BCSA_ECOLI The genes bscA, bcsB, bcsZ and bcsC are constitutively transcribed but cellulose synthesis occurs only when AdrA, a putative transmembrane protein regulated by AgfD, is expressed. Cellulose production is abolished in E.coli K12. # Organism BCSA_ECOLI Escherichia coli (strain K12) # PATHWAY BCSA_ECOLI Glycan metabolism; bacterial cellulose biosynthesis. # PATRIC 32122532 VBIEscCol129921_3644 # PIR H65151 H65151 # PIR S47754 S47754 # PIR S47755 S47755 # PRINTS PR01439 CELLSNTHASEA # Pfam PF00535 Glycos_transf_2 # Pfam PF03552 Cellulose_synt # Pfam PF07238 PilZ # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BCSA_ECOLI Cellulose synthase catalytic subunit [UDP-forming] # RefSeq NP_417990 NC_000913.3 # RefSeq WP_000025892 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18511.1; Type=Frameshift; Positions=128; Evidence={ECO 0000305}; # SIMILARITY Belongs to the glycosyltransferase 2 family. {ECO 0000305}. # SIMILARITY Contains 1 PilZ domain. {ECO 0000305}. # SUBCELLULAR LOCATION BCSA_ECOLI Cell inner membrane {ECO 0000305}; Multi- pass membrane protein {ECO 0000305}. # SUPFAM SSF53448 SSF53448 # TCDB 4.D.3.1 the glycan glucosyl transferase (opgh) family # TIGRFAMs TIGR03030 CelA # eggNOG COG1215 LUCA # eggNOG ENOG4107QZ7 Bacteria BLAST swissprot:BCSA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BCSA_ECOLI BioCyc ECOL316407:JW5665-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5665-MONOMER BioCyc EcoCyc:EG12260-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12260-MONOMER BioCyc MetaCyc:EG12260-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12260-MONOMER COG COG1215 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1215 DIP DIP-12387N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12387N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2001.02337.x http://dx.doi.org/10.1046/j.1365-2958.2001.02337.x DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.4.1.12 http://www.genome.jp/dbget-bin/www_bget?EC:2.4.1.12 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.4.1.12 http://enzyme.expasy.org/EC/2.4.1.12 EchoBASE EB2169 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2169 EcoGene EG12260 http://www.ecogene.org/geneInfo.php?eg_id=EG12260 EnsemblBacteria AAC76558 http://www.ensemblgenomes.org/id/AAC76558 EnsemblBacteria AAC76558 http://www.ensemblgenomes.org/id/AAC76558 EnsemblBacteria BAE77761 http://www.ensemblgenomes.org/id/BAE77761 EnsemblBacteria BAE77761 http://www.ensemblgenomes.org/id/BAE77761 EnsemblBacteria BAE77761 http://www.ensemblgenomes.org/id/BAE77761 EnsemblBacteria b3533 http://www.ensemblgenomes.org/id/b3533 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0016758 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016758 GO_function GO:0016760 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016760 GO_function GO:0035438 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035438 GO_process GO:0006011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006011 GO_process GO:0090540 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090540 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.90.550.10 http://www.cathdb.info/version/latest/superfamily/3.90.550.10 GeneID 948053 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948053 HOGENOM HOG000259144 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000259144&db=HOGENOM6 InParanoid P37653 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37653 IntAct P37653 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37653* IntEnz 2.4.1.12 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.1.12 InterPro IPR001173 http://www.ebi.ac.uk/interpro/entry/IPR001173 InterPro IPR003919 http://www.ebi.ac.uk/interpro/entry/IPR003919 InterPro IPR005150 http://www.ebi.ac.uk/interpro/entry/IPR005150 InterPro IPR009875 http://www.ebi.ac.uk/interpro/entry/IPR009875 InterPro IPR029044 http://www.ebi.ac.uk/interpro/entry/IPR029044 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01003 http://www.genome.jp/dbget-bin/www_bget?ko01003 KEGG_Gene ecj:JW5665 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5665 KEGG_Gene eco:b3533 http://www.genome.jp/dbget-bin/www_bget?eco:b3533 KEGG_Orthology KO:K00694 http://www.genome.jp/dbget-bin/www_bget?KO:K00694 KEGG_Pathway ko00500 http://www.genome.jp/kegg-bin/show_pathway?ko00500 KEGG_Reaction rn:R02889 http://www.genome.jp/dbget-bin/www_bget?rn:R02889 OMA QLTMGWF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QLTMGWF PRINTS PR01439 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01439 PSORT swissprot:BCSA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BCSA_ECOLI PSORT-B swissprot:BCSA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BCSA_ECOLI PSORT2 swissprot:BCSA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BCSA_ECOLI Pfam PF00535 http://pfam.xfam.org/family/PF00535 Pfam PF03552 http://pfam.xfam.org/family/PF03552 Pfam PF07238 http://pfam.xfam.org/family/PF07238 Phobius swissprot:BCSA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BCSA_ECOLI PhylomeDB P37653 http://phylomedb.org/?seqid=P37653 ProteinModelPortal P37653 http://www.proteinmodelportal.org/query/uniprot/P37653 PubMed 11260463 http://www.ncbi.nlm.nih.gov/pubmed/11260463 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417990 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417990 RefSeq WP_000025892 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000025892 SMR P37653 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37653 STRING 511145.b3533 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3533&targetmode=cogs STRING COG1215 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1215&targetmode=cogs SUPFAM SSF53448 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53448 TCDB 4.D.3.1 http://www.tcdb.org/search/result.php?tc=4.D.3.1 TIGRFAMs TIGR03030 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03030 UniProtKB BCSA_ECOLI http://www.uniprot.org/uniprot/BCSA_ECOLI UniProtKB-AC P37653 http://www.uniprot.org/uniprot/P37653 charge swissprot:BCSA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BCSA_ECOLI eggNOG COG1215 http://eggnogapi.embl.de/nog_data/html/tree/COG1215 eggNOG ENOG4107QZ7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QZ7 epestfind swissprot:BCSA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BCSA_ECOLI garnier swissprot:BCSA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BCSA_ECOLI helixturnhelix swissprot:BCSA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BCSA_ECOLI hmoment swissprot:BCSA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BCSA_ECOLI iep swissprot:BCSA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BCSA_ECOLI inforesidue swissprot:BCSA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BCSA_ECOLI octanol swissprot:BCSA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BCSA_ECOLI pepcoil swissprot:BCSA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BCSA_ECOLI pepdigest swissprot:BCSA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BCSA_ECOLI pepinfo swissprot:BCSA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BCSA_ECOLI pepnet swissprot:BCSA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BCSA_ECOLI pepstats swissprot:BCSA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BCSA_ECOLI pepwheel swissprot:BCSA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BCSA_ECOLI pepwindow swissprot:BCSA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BCSA_ECOLI sigcleave swissprot:BCSA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BCSA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259198 13 # EcoGene EG14212 hyfD # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; ISS:EcoliWiki. # GO_function GO:0016491 oxidoreductase activity; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016491 oxidoreductase activity # InterPro IPR001516 Proton_antipo_N # InterPro IPR001750 ND/Mrp_mem # KEGG_Brite ko01000 Enzymes # Organism HYFD_ECOLI Escherichia coli (strain K12) # PATRIC 32120355 VBIEscCol129921_2580 # PIR C65024 C65024 # Pfam PF00361 Proton_antipo_M # Pfam PF00662 Proton_antipo_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HYFD_ECOLI Hydrogenase-4 component D # RefSeq NP_416979 NC_000913.3 # RefSeq WP_000429104 NZ_LN832404.1 # SIMILARITY Belongs to the complex I subunit 5 family. {ECO 0000305}. # SUBCELLULAR LOCATION HYFD_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # TCDB 3.D.1.9 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family # eggNOG COG1009 LUCA # eggNOG ENOG4105D65 Bacteria BLAST swissprot:HYFD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HYFD_ECOLI BioCyc ECOL316407:JW2469-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2469-MONOMER BioCyc EcoCyc:MONOMER0-141 http://biocyc.org/getid?id=EcoCyc:MONOMER0-141 COG COG1009 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1009 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M63654 http://www.ebi.ac.uk/ena/data/view/M63654 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- EchoBASE EB3964 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3964 EcoGene EG14212 http://www.ecogene.org/geneInfo.php?eg_id=EG14212 EnsemblBacteria AAC75537 http://www.ensemblgenomes.org/id/AAC75537 EnsemblBacteria AAC75537 http://www.ensemblgenomes.org/id/AAC75537 EnsemblBacteria BAA16372 http://www.ensemblgenomes.org/id/BAA16372 EnsemblBacteria BAA16372 http://www.ensemblgenomes.org/id/BAA16372 EnsemblBacteria BAA16372 http://www.ensemblgenomes.org/id/BAA16372 EnsemblBacteria b2484 http://www.ensemblgenomes.org/id/b2484 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GeneID 947290 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947290 HOGENOM HOG000219587 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219587&db=HOGENOM6 InParanoid P77416 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77416 IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR001516 http://www.ebi.ac.uk/interpro/entry/IPR001516 InterPro IPR001750 http://www.ebi.ac.uk/interpro/entry/IPR001750 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2469 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2469 KEGG_Gene eco:b2484 http://www.genome.jp/dbget-bin/www_bget?eco:b2484 KEGG_Orthology KO:K12139 http://www.genome.jp/dbget-bin/www_bget?KO:K12139 OMA SLSVEYW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SLSVEYW PSORT swissprot:HYFD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HYFD_ECOLI PSORT-B swissprot:HYFD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HYFD_ECOLI PSORT2 swissprot:HYFD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HYFD_ECOLI Pfam PF00361 http://pfam.xfam.org/family/PF00361 Pfam PF00662 http://pfam.xfam.org/family/PF00662 Phobius swissprot:HYFD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HYFD_ECOLI PhylomeDB P77416 http://phylomedb.org/?seqid=P77416 ProteinModelPortal P77416 http://www.proteinmodelportal.org/query/uniprot/P77416 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416979 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416979 RefSeq WP_000429104 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000429104 STRING 511145.b2484 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2484&targetmode=cogs STRING COG1009 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1009&targetmode=cogs TCDB 3.D.1.9 http://www.tcdb.org/search/result.php?tc=3.D.1.9 UniProtKB HYFD_ECOLI http://www.uniprot.org/uniprot/HYFD_ECOLI UniProtKB-AC P77416 http://www.uniprot.org/uniprot/P77416 charge swissprot:HYFD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HYFD_ECOLI eggNOG COG1009 http://eggnogapi.embl.de/nog_data/html/tree/COG1009 eggNOG ENOG4105D65 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D65 epestfind swissprot:HYFD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HYFD_ECOLI garnier swissprot:HYFD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HYFD_ECOLI helixturnhelix swissprot:HYFD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HYFD_ECOLI hmoment swissprot:HYFD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HYFD_ECOLI iep swissprot:HYFD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HYFD_ECOLI inforesidue swissprot:HYFD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HYFD_ECOLI octanol swissprot:HYFD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HYFD_ECOLI pepcoil swissprot:HYFD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HYFD_ECOLI pepdigest swissprot:HYFD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HYFD_ECOLI pepinfo swissprot:HYFD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HYFD_ECOLI pepnet swissprot:HYFD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HYFD_ECOLI pepstats swissprot:HYFD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HYFD_ECOLI pepwheel swissprot:HYFD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HYFD_ECOLI pepwindow swissprot:HYFD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HYFD_ECOLI sigcleave swissprot:HYFD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HYFD_ECOLI ## Database ID URL or Descriptions # BioGrid 4263269 117 # EcoGene EG12405 ychO # GO_component GO:0009279 cell outer membrane; IBA:GO_Central. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_process GO:0009405 pathogenesis; IBA:GO_Central. # GO_process GO:0030260 entry into host cell; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0008150 biological_process # IntAct P39165 7 # InterPro IPR024519 IAT_beta # Organism YCHO_ECOLI Escherichia coli (strain K12) # PATRIC 32117698 VBIEscCol129921_1271 # PIR A64869 A64869 # Pfam PF11924 IAT_beta # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCHO_ECOLI Uncharacterized protein YchO # RefSeq NP_415738 NC_000913.3 # RefSeq WP_000086217 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=X69189; Type=Frameshift; Positions=445; Evidence={ECO 0000305}; # SIMILARITY Belongs to the intimin/invasin family. {ECO 0000305}. # SUBCELLULAR LOCATION YCHO_ECOLI Periplasm {ECO 0000305}. # TCDB 1.B.54.1 the intimin/invasin (int/inv) or autotransporter-3 (at-3) family # eggNOG ENOG4105ID0 Bacteria # eggNOG ENOG410XSN7 LUCA BLAST swissprot:YCHO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCHO_ECOLI BioCyc ECOL316407:JW1211-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1211-MONOMER BioCyc EcoCyc:EG12405-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12405-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/17.8.2947 http://dx.doi.org/10.1093/nar/17.8.2947 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L28709 http://www.ebi.ac.uk/ena/data/view/L28709 EMBL M24910 http://www.ebi.ac.uk/ena/data/view/M24910 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X13360 http://www.ebi.ac.uk/ena/data/view/X13360 EMBL X69189 http://www.ebi.ac.uk/ena/data/view/X69189 EchoBASE EB2305 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2305 EcoGene EG12405 http://www.ecogene.org/geneInfo.php?eg_id=EG12405 EnsemblBacteria AAC74304 http://www.ensemblgenomes.org/id/AAC74304 EnsemblBacteria AAC74304 http://www.ensemblgenomes.org/id/AAC74304 EnsemblBacteria BAA36088 http://www.ensemblgenomes.org/id/BAA36088 EnsemblBacteria BAA36088 http://www.ensemblgenomes.org/id/BAA36088 EnsemblBacteria BAA36088 http://www.ensemblgenomes.org/id/BAA36088 EnsemblBacteria b1220 http://www.ensemblgenomes.org/id/b1220 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_process GO:0009405 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009405 GO_process GO:0030260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030260 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 945801 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945801 HOGENOM HOG000119789 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000119789&db=HOGENOM6 InParanoid P39165 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39165 IntAct P39165 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39165* InterPro IPR024519 http://www.ebi.ac.uk/interpro/entry/IPR024519 KEGG_Gene ecj:JW1211 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1211 KEGG_Gene eco:b1220 http://www.genome.jp/dbget-bin/www_bget?eco:b1220 OMA RFSANYY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RFSANYY PSORT swissprot:YCHO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCHO_ECOLI PSORT-B swissprot:YCHO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCHO_ECOLI PSORT2 swissprot:YCHO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCHO_ECOLI Pfam PF11924 http://pfam.xfam.org/family/PF11924 Phobius swissprot:YCHO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCHO_ECOLI ProteinModelPortal P39165 http://www.proteinmodelportal.org/query/uniprot/P39165 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2649492 http://www.ncbi.nlm.nih.gov/pubmed/2649492 PubMed 2657652 http://www.ncbi.nlm.nih.gov/pubmed/2657652 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415738 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415738 RefSeq WP_000086217 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000086217 SMR P39165 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39165 STRING 511145.b1220 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1220&targetmode=cogs TCDB 1.B.54.1 http://www.tcdb.org/search/result.php?tc=1.B.54.1 UniProtKB YCHO_ECOLI http://www.uniprot.org/uniprot/YCHO_ECOLI UniProtKB-AC P39165 http://www.uniprot.org/uniprot/P39165 charge swissprot:YCHO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCHO_ECOLI eggNOG ENOG4105ID0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ID0 eggNOG ENOG410XSN7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XSN7 epestfind swissprot:YCHO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCHO_ECOLI garnier swissprot:YCHO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCHO_ECOLI helixturnhelix swissprot:YCHO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCHO_ECOLI hmoment swissprot:YCHO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCHO_ECOLI iep swissprot:YCHO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCHO_ECOLI inforesidue swissprot:YCHO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCHO_ECOLI octanol swissprot:YCHO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCHO_ECOLI pepcoil swissprot:YCHO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCHO_ECOLI pepdigest swissprot:YCHO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCHO_ECOLI pepinfo swissprot:YCHO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCHO_ECOLI pepnet swissprot:YCHO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCHO_ECOLI pepstats swissprot:YCHO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCHO_ECOLI pepwheel swissprot:YCHO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCHO_ECOLI pepwindow swissprot:YCHO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCHO_ECOLI sigcleave swissprot:YCHO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCHO_ECOLI ## Database ID URL or Descriptions # BioGrid 4261852 10 # COFACTOR Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI 49883; Note=Binds 1 [4Fe-4S] cluster per subunit.; # DOMAIN FNR_ECOLI The amino acid residues contacting the FNR target site on the DNA (5'-TTGATNNNNATCAA-3') are located in the putative DNA- recognition helix (alphaF), which contains the FNR motif (EXXSR). Three surface-exposed loops forming activating region 1 (AR1) in the downstream subunit of the dimer contact the C-terminal domain of the alpha subunit (alphaCTD) of RNA polymerase for activation of class I promoters (the 161-121 loop is the major AR1 activating determinant). At class II promoters, the AR1 of the upstream subunit contacts alphaCTD, promoting open complex formation; activating region 3 (AR3) of the downstream subunit contacts region 4 of the sigma70 subunit of RNA polymerase, to effect direct activation. At promoters repressed by FNR, tandem FNR dimers might interact with each other at AR1 to restrict access to a promoter or jam the promoter by their dual interaction with RNA polymerase alphaCTD. # EcoGene EG10325 fnr # FUNCTION FNR_ECOLI Global transcription factor that controls the expression of over 100 target genes in response to anoxia. It facilitates the adaptation to anaerobic growth conditions by regulating the expression of gene products that are involved in anaerobic energy metabolism. When the terminal electron acceptor, O(2), is no longer available, it represses the synthesis of enzymes involved in aerobic respiration and increases the synthesis of enzymes required for anaerobic respiration. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051536 iron-sulfur cluster binding; IDA:EcoCyc. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEP:EcoCyc. # GO_process GO:0009061 anaerobic respiration; IEP:EcoCyc. # GO_process GO:0071731 response to nitric oxide; IEP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # Gene3D 2.60.120.10 -; 1. # IntAct P0A9E5 8 # InterPro IPR000595 cNMP-bd_dom # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR012318 HTH_CRP # InterPro IPR014710 RmlC-like_jellyroll # InterPro IPR018335 Tscrpt_reg_HTH_Crp-type_CS # InterPro IPR018490 cNMP-bd-like # KEGG_Brite ko03000 Transcription factors # MASS SPECTROMETRY Mass=26823; Mass_error=6; Method=Electrospray; Range=10-250; Evidence={ECO:0000269|PubMed 8497198}; # MISCELLANEOUS FNR_ECOLI FNR senses the oxygen concentration directly via the disassembly and reassembly of the [4Fe-4S] clusters. Anaerobic, de novo acquisition of the iron-sulfur cluster converts monomeric, inactive apo-FNR into a dimeric form containing two [4Fe-4S] clusters. This, in turn, enhances the affinity of FNR for specific DNA targets and mediates transcription regulation by establishing direct FNR-RNA polymerase contacts. With the increase in intracellular oxygen concentration, the [4Fe-4S] cluster is oxidized, producing a [2Fe-2S] cluster, which decays to apo-FNR. Apo-FNR [4SH] can be reversibly oxidized to a disulfide form [2SH,S-S], suggesting that FNR may be able to sense oxidative stress as well as normoxia. This interconversion may be mediated by agents such as glutathione or thioredoxin. # Organism FNR_ECOLI Escherichia coli (strain K12) # PATRIC 32117944 VBIEscCol129921_1392 # PIR A64883 RGECF # PRINTS PR00034 HTHCRP # PROSITE PS00042 HTH_CRP_1 # PROSITE PS50042 CNMP_BINDING_3 # PROSITE PS51063 HTH_CRP_2 # Pfam PF00027 cNMP_binding # Pfam PF13545 HTH_Crp_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FNR_ECOLI Fumarate and nitrate reduction regulatory protein # RefSeq NP_415850 NC_000913.3 # RefSeq WP_000611911 NZ_LN832404.1 # SIMILARITY Contains 1 HTH crp-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00387}. # SIMILARITY Contains 1 cyclic nucleotide-binding domain. {ECO:0000255|PROSITE-ProRule PRU00060}. # SMART SM00100 cNMP # SMART SM00419 HTH_CRP # SUBCELLULAR LOCATION FNR_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT FNR_ECOLI Homodimer. # SUPFAM SSF46785 SSF46785 # SUPFAM SSF51206 SSF51206 # eggNOG COG0664 LUCA # eggNOG ENOG4105DS0 Bacteria BLAST swissprot:FNR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FNR_ECOLI BioCyc ECOL316407:JW1328-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1328-MONOMER BioCyc EcoCyc:PD00197 http://biocyc.org/getid?id=EcoCyc:PD00197 COG COG0664 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0664 DIP DIP-9669N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9669N DOI 10.1016/0014-5793(90)81248-M http://dx.doi.org/10.1016/0014-5793(90)81248-M DOI 10.1016/S0065-2911(01)44010-0 http://dx.doi.org/10.1016/S0065-2911(01)44010-0 DOI 10.1016/S0168-6445(05)80007-5 http://dx.doi.org/10.1016/S0168-6445(05)80007-5 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2000.02172.x http://dx.doi.org/10.1046/j.1365-2958.2000.02172.x DOI 10.1073/pnas.94.12.6087 http://dx.doi.org/10.1073/pnas.94.12.6087 DOI 10.1074/jbc.M106569200 http://dx.doi.org/10.1074/jbc.M106569200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/10.19.6119 http://dx.doi.org/10.1093/nar/10.19.6119 DOI 10.1093/nar/19.24.6705 http://dx.doi.org/10.1093/nar/19.24.6705 DOI 10.1093/nar/25.20.4028 http://dx.doi.org/10.1093/nar/25.20.4028 DOI 10.1101/gad.7.10.1993 http://dx.doi.org/10.1101/gad.7.10.1993 DOI 10.1111/j.1365-2958.1990.tb02011.x http://dx.doi.org/10.1111/j.1365-2958.1990.tb02011.x DOI 10.1111/j.1365-2958.1993.tb01203.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb01203.x DOI 10.1111/j.1365-2958.2001.02326.x http://dx.doi.org/10.1111/j.1365-2958.2001.02326.x DOI 10.1111/j.1574-6976.1998.tb00375.x http://dx.doi.org/10.1111/j.1574-6976.1998.tb00375.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01608 http://www.ebi.ac.uk/ena/data/view/J01608 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0321 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0321 EcoGene EG10325 http://www.ecogene.org/geneInfo.php?eg_id=EG10325 EnsemblBacteria AAC74416 http://www.ensemblgenomes.org/id/AAC74416 EnsemblBacteria AAC74416 http://www.ensemblgenomes.org/id/AAC74416 EnsemblBacteria BAA14927 http://www.ensemblgenomes.org/id/BAA14927 EnsemblBacteria BAA14927 http://www.ensemblgenomes.org/id/BAA14927 EnsemblBacteria BAA14927 http://www.ensemblgenomes.org/id/BAA14927 EnsemblBacteria b1334 http://www.ensemblgenomes.org/id/b1334 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051536 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051536 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0009061 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009061 GO_process GO:0071731 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071731 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 2.60.120.10 http://www.cathdb.info/version/latest/superfamily/2.60.120.10 GeneID 945908 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945908 HOGENOM HOG000186461 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000186461&db=HOGENOM6 InParanoid P0A9E5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9E5 IntAct P0A9E5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9E5* InterPro IPR000595 http://www.ebi.ac.uk/interpro/entry/IPR000595 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR012318 http://www.ebi.ac.uk/interpro/entry/IPR012318 InterPro IPR014710 http://www.ebi.ac.uk/interpro/entry/IPR014710 InterPro IPR018335 http://www.ebi.ac.uk/interpro/entry/IPR018335 InterPro IPR018490 http://www.ebi.ac.uk/interpro/entry/IPR018490 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW1328 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1328 KEGG_Gene eco:b1334 http://www.genome.jp/dbget-bin/www_bget?eco:b1334 KEGG_Orthology KO:K01420 http://www.genome.jp/dbget-bin/www_bget?KO:K01420 MINT MINT-1237977 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1237977 OMA HVHKIMS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HVHKIMS PRINTS PR00034 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00034 PROSITE PS00042 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00042 PROSITE PS50042 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50042 PROSITE PS51063 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51063 PSORT swissprot:FNR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FNR_ECOLI PSORT-B swissprot:FNR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FNR_ECOLI PSORT2 swissprot:FNR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FNR_ECOLI Pfam PF00027 http://pfam.xfam.org/family/PF00027 Pfam PF13545 http://pfam.xfam.org/family/PF13545 Phobius swissprot:FNR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FNR_ECOLI PhylomeDB P0A9E5 http://phylomedb.org/?seqid=P0A9E5 ProteinModelPortal P0A9E5 http://www.proteinmodelportal.org/query/uniprot/P0A9E5 PubMed 11115116 http://www.ncbi.nlm.nih.gov/pubmed/11115116 PubMed 11251837 http://www.ncbi.nlm.nih.gov/pubmed/11251837 PubMed 11407111 http://www.ncbi.nlm.nih.gov/pubmed/11407111 PubMed 11581261 http://www.ncbi.nlm.nih.gov/pubmed/11581261 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1762901 http://www.ncbi.nlm.nih.gov/pubmed/1762901 PubMed 1898918 http://www.ncbi.nlm.nih.gov/pubmed/1898918 PubMed 2181237 http://www.ncbi.nlm.nih.gov/pubmed/2181237 PubMed 2226775 http://www.ncbi.nlm.nih.gov/pubmed/2226775 PubMed 2248796 http://www.ncbi.nlm.nih.gov/pubmed/2248796 PubMed 6292868 http://www.ncbi.nlm.nih.gov/pubmed/6292868 PubMed 8406003 http://www.ncbi.nlm.nih.gov/pubmed/8406003 PubMed 8497198 http://www.ncbi.nlm.nih.gov/pubmed/8497198 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9177174 http://www.ncbi.nlm.nih.gov/pubmed/9177174 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9321653 http://www.ncbi.nlm.nih.gov/pubmed/9321653 PubMed 9990723 http://www.ncbi.nlm.nih.gov/pubmed/9990723 RefSeq NP_415850 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415850 RefSeq WP_000611911 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000611911 SMART SM00100 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00100 SMART SM00419 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00419 SMR P0A9E5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9E5 STRING 511145.b1334 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1334&targetmode=cogs STRING COG0664 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0664&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SUPFAM SSF51206 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51206 UniProtKB FNR_ECOLI http://www.uniprot.org/uniprot/FNR_ECOLI UniProtKB-AC P0A9E5 http://www.uniprot.org/uniprot/P0A9E5 charge swissprot:FNR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FNR_ECOLI eggNOG COG0664 http://eggnogapi.embl.de/nog_data/html/tree/COG0664 eggNOG ENOG4105DS0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DS0 epestfind swissprot:FNR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FNR_ECOLI garnier swissprot:FNR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FNR_ECOLI helixturnhelix swissprot:FNR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FNR_ECOLI hmoment swissprot:FNR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FNR_ECOLI iep swissprot:FNR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FNR_ECOLI inforesidue swissprot:FNR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FNR_ECOLI octanol swissprot:FNR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FNR_ECOLI pepcoil swissprot:FNR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FNR_ECOLI pepdigest swissprot:FNR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FNR_ECOLI pepinfo swissprot:FNR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FNR_ECOLI pepnet swissprot:FNR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FNR_ECOLI pepstats swissprot:FNR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FNR_ECOLI pepwheel swissprot:FNR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FNR_ECOLI pepwindow swissprot:FNR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FNR_ECOLI sigcleave swissprot:FNR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FNR_ECOLI ## Database ID URL or Descriptions # AltName CREA_ECOLI Catabolite regulation protein A # BioGrid 4259351 8 # DISRUPTION PHENOTYPE No crucial effects on activation of cre regulon gene expression during aerobic growth on glucose or pyruvate minimal medium or during anaerobic growth on glucose minimal medium. {ECO:0000269|PubMed 18375564}. # EcoGene EG11217 creA # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # InterPro IPR010292 Uncharacterised_CreA # Organism CREA_ECOLI Escherichia coli (strain K12) # PATRIC 32124412 VBIEscCol129921_4546 # PIR A25038 QQECF1 # PIRSF PIRSF003174 CreA # Pfam PF05981 CreA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CREA_ECOLI Protein CreA # RefSeq NP_418814 NC_000913.3 # RefSeq WP_000875487 NZ_LN832404.1 # eggNOG COG3045 LUCA # eggNOG ENOG4108RH0 Bacteria BLAST swissprot:CREA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CREA_ECOLI BioCyc ECOL316407:JW4360-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4360-MONOMER BioCyc EcoCyc:EG11217-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11217-MONOMER COG COG3045 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3045 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00108-08 http://dx.doi.org/10.1128/JB.00108-08 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M13608 http://www.ebi.ac.uk/ena/data/view/M13608 EMBL M97495 http://www.ebi.ac.uk/ena/data/view/M97495 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB1200 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1200 EcoGene EG11217 http://www.ecogene.org/geneInfo.php?eg_id=EG11217 EnsemblBacteria AAC77350 http://www.ensemblgenomes.org/id/AAC77350 EnsemblBacteria AAC77350 http://www.ensemblgenomes.org/id/AAC77350 EnsemblBacteria BAE78386 http://www.ensemblgenomes.org/id/BAE78386 EnsemblBacteria BAE78386 http://www.ensemblgenomes.org/id/BAE78386 EnsemblBacteria BAE78386 http://www.ensemblgenomes.org/id/BAE78386 EnsemblBacteria b4397 http://www.ensemblgenomes.org/id/b4397 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GeneID 948920 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948920 HOGENOM HOG000257967 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000257967&db=HOGENOM6 InParanoid P0AE91 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AE91 IntAct P0AE91 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AE91* InterPro IPR010292 http://www.ebi.ac.uk/interpro/entry/IPR010292 KEGG_Gene ecj:JW4360 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4360 KEGG_Gene eco:b4397 http://www.genome.jp/dbget-bin/www_bget?eco:b4397 KEGG_Orthology KO:K05805 http://www.genome.jp/dbget-bin/www_bget?KO:K05805 OMA SPQNSVT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SPQNSVT PSORT swissprot:CREA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CREA_ECOLI PSORT-B swissprot:CREA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CREA_ECOLI PSORT2 swissprot:CREA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CREA_ECOLI Pfam PF05981 http://pfam.xfam.org/family/PF05981 Phobius swissprot:CREA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CREA_ECOLI PhylomeDB P0AE91 http://phylomedb.org/?seqid=P0AE91 ProteinModelPortal P0AE91 http://www.proteinmodelportal.org/query/uniprot/P0AE91 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18375564 http://www.ncbi.nlm.nih.gov/pubmed/18375564 PubMed 3531171 http://www.ncbi.nlm.nih.gov/pubmed/3531171 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8449900 http://www.ncbi.nlm.nih.gov/pubmed/8449900 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418814 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418814 RefSeq WP_000875487 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000875487 STRING 511145.b4397 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4397&targetmode=cogs STRING COG3045 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3045&targetmode=cogs UniProtKB CREA_ECOLI http://www.uniprot.org/uniprot/CREA_ECOLI UniProtKB-AC P0AE91 http://www.uniprot.org/uniprot/P0AE91 charge swissprot:CREA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CREA_ECOLI eggNOG COG3045 http://eggnogapi.embl.de/nog_data/html/tree/COG3045 eggNOG ENOG4108RH0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108RH0 epestfind swissprot:CREA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CREA_ECOLI garnier swissprot:CREA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CREA_ECOLI helixturnhelix swissprot:CREA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CREA_ECOLI hmoment swissprot:CREA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CREA_ECOLI iep swissprot:CREA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CREA_ECOLI inforesidue swissprot:CREA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CREA_ECOLI octanol swissprot:CREA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CREA_ECOLI pepcoil swissprot:CREA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CREA_ECOLI pepdigest swissprot:CREA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CREA_ECOLI pepinfo swissprot:CREA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CREA_ECOLI pepnet swissprot:CREA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CREA_ECOLI pepstats swissprot:CREA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CREA_ECOLI pepwheel swissprot:CREA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CREA_ECOLI pepwindow swissprot:CREA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CREA_ECOLI sigcleave swissprot:CREA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CREA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259348 46 # CDD cd00947 TBP_aldolase_IIB # EcoGene EG13485 ydjI # GO_function GO:0008270 zinc ion binding; IEA:InterPro. # GO_function GO:0016832 aldehyde-lyase activity; IEA:InterPro. # GO_process GO:0005975 carbohydrate metabolic process; IEA:InterPro. # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # Gene3D 3.20.20.70 -; 1. # IntAct P77704 7 # InterPro IPR000771 FBA_II # InterPro IPR013785 Aldolase_TIM # Organism YDJI_ECOLI Escherichia coli (strain K12) # PATRIC 32118857 VBIEscCol129921_1846 # PIR E64937 E64937 # PIRSF PIRSF001359 F_bP_aldolase_II # Pfam PF01116 F_bP_aldolase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDJI_ECOLI Uncharacterized protein YdjI # RefSeq NP_416287 NC_000913.3 # RefSeq WP_000878893 NZ_LN832404.1 # TIGRFAMs TIGR00167 cbbA # eggNOG COG0191 LUCA # eggNOG ENOG4105D2N Bacteria BLAST swissprot:YDJI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDJI_ECOLI BioCyc ECOL316407:JW1762-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1762-MONOMER BioCyc EcoCyc:G6960-MONOMER http://biocyc.org/getid?id=EcoCyc:G6960-MONOMER DIP DIP-28071N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-28071N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3258 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3258 EcoGene EG13485 http://www.ecogene.org/geneInfo.php?eg_id=EG13485 EnsemblBacteria AAC74843 http://www.ensemblgenomes.org/id/AAC74843 EnsemblBacteria AAC74843 http://www.ensemblgenomes.org/id/AAC74843 EnsemblBacteria BAA15564 http://www.ensemblgenomes.org/id/BAA15564 EnsemblBacteria BAA15564 http://www.ensemblgenomes.org/id/BAA15564 EnsemblBacteria BAA15564 http://www.ensemblgenomes.org/id/BAA15564 EnsemblBacteria b1773 http://www.ensemblgenomes.org/id/b1773 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0016832 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016832 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 946291 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946291 HOGENOM HOG000227793 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000227793&db=HOGENOM6 InParanoid P77704 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77704 IntAct P77704 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77704* InterPro IPR000771 http://www.ebi.ac.uk/interpro/entry/IPR000771 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 KEGG_Gene ecj:JW1762 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1762 KEGG_Gene eco:b1773 http://www.genome.jp/dbget-bin/www_bget?eco:b1773 OMA EWLAIIR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EWLAIIR PSORT swissprot:YDJI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDJI_ECOLI PSORT-B swissprot:YDJI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDJI_ECOLI PSORT2 swissprot:YDJI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDJI_ECOLI Pfam PF01116 http://pfam.xfam.org/family/PF01116 Phobius swissprot:YDJI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDJI_ECOLI PhylomeDB P77704 http://phylomedb.org/?seqid=P77704 ProteinModelPortal P77704 http://www.proteinmodelportal.org/query/uniprot/P77704 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416287 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416287 RefSeq WP_000878893 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000878893 SMR P77704 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77704 STRING 511145.b1773 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1773&targetmode=cogs TIGRFAMs TIGR00167 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00167 UniProtKB YDJI_ECOLI http://www.uniprot.org/uniprot/YDJI_ECOLI UniProtKB-AC P77704 http://www.uniprot.org/uniprot/P77704 charge swissprot:YDJI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDJI_ECOLI eggNOG COG0191 http://eggnogapi.embl.de/nog_data/html/tree/COG0191 eggNOG ENOG4105D2N http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D2N epestfind swissprot:YDJI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDJI_ECOLI garnier swissprot:YDJI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDJI_ECOLI helixturnhelix swissprot:YDJI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDJI_ECOLI hmoment swissprot:YDJI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDJI_ECOLI iep swissprot:YDJI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDJI_ECOLI inforesidue swissprot:YDJI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDJI_ECOLI octanol swissprot:YDJI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDJI_ECOLI pepcoil swissprot:YDJI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDJI_ECOLI pepdigest swissprot:YDJI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDJI_ECOLI pepinfo swissprot:YDJI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDJI_ECOLI pepnet swissprot:YDJI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDJI_ECOLI pepstats swissprot:YDJI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDJI_ECOLI pepwheel swissprot:YDJI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDJI_ECOLI pepwindow swissprot:YDJI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDJI_ECOLI sigcleave swissprot:YDJI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDJI_ECOLI ## Database ID URL or Descriptions # AltName RACR_ECOLI Rac prophage repressor # EcoGene EG13360 racR # FUNCTION RACR_ECOLI Repressor protein for rac prophage. {ECO 0000269|Ref.3}. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.260.40 -; 1. # IntAct P76062 12 # InterPro IPR010982 Lambda_DNA-bd_dom # Organism RACR_ECOLI Escherichia coli (strain K12) # PATRIC 32117992 VBIEscCol129921_1416 # PIR G64885 G64885 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Prophage repressor RacR {ECO 0000305} # RefSeq NP_415874 NC_000913.3 # RefSeq WP_000948459 NZ_CP014272.1 # eggNOG ENOG410649Z Bacteria # eggNOG ENOG41126JH LUCA BLAST swissprot:RACR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RACR_ECOLI BioCyc ECOL316407:JW1351-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1351-MONOMER BioCyc EcoCyc:G6680-MONOMER http://biocyc.org/getid?id=EcoCyc:G6680-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3143 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3143 EcoGene EG13360 http://www.ecogene.org/geneInfo.php?eg_id=EG13360 EnsemblBacteria AAC74438 http://www.ensemblgenomes.org/id/AAC74438 EnsemblBacteria AAC74438 http://www.ensemblgenomes.org/id/AAC74438 EnsemblBacteria BAE76411 http://www.ensemblgenomes.org/id/BAE76411 EnsemblBacteria BAE76411 http://www.ensemblgenomes.org/id/BAE76411 EnsemblBacteria BAE76411 http://www.ensemblgenomes.org/id/BAE76411 EnsemblBacteria b1356 http://www.ensemblgenomes.org/id/b1356 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.260.40 http://www.cathdb.info/version/latest/superfamily/1.10.260.40 GeneID 945899 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945899 HOGENOM HOG000054871 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000054871&db=HOGENOM6 IntAct P76062 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76062* InterPro IPR010982 http://www.ebi.ac.uk/interpro/entry/IPR010982 KEGG_Gene ecj:JW1351 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1351 KEGG_Gene eco:b1356 http://www.genome.jp/dbget-bin/www_bget?eco:b1356 OMA YMSASAE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YMSASAE PSORT swissprot:RACR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RACR_ECOLI PSORT-B swissprot:RACR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RACR_ECOLI PSORT2 swissprot:RACR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RACR_ECOLI Phobius swissprot:RACR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RACR_ECOLI ProteinModelPortal P76062 http://www.proteinmodelportal.org/query/uniprot/P76062 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415874 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415874 RefSeq WP_000948459 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000948459 SMR P76062 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76062 STRING 511145.b1356 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1356&targetmode=cogs UniProtKB RACR_ECOLI http://www.uniprot.org/uniprot/RACR_ECOLI UniProtKB-AC P76062 http://www.uniprot.org/uniprot/P76062 charge swissprot:RACR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RACR_ECOLI eggNOG ENOG410649Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG410649Z eggNOG ENOG41126JH http://eggnogapi.embl.de/nog_data/html/tree/ENOG41126JH epestfind swissprot:RACR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RACR_ECOLI garnier swissprot:RACR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RACR_ECOLI helixturnhelix swissprot:RACR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RACR_ECOLI hmoment swissprot:RACR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RACR_ECOLI iep swissprot:RACR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RACR_ECOLI inforesidue swissprot:RACR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RACR_ECOLI octanol swissprot:RACR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RACR_ECOLI pepcoil swissprot:RACR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RACR_ECOLI pepdigest swissprot:RACR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RACR_ECOLI pepinfo swissprot:RACR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RACR_ECOLI pepnet swissprot:RACR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RACR_ECOLI pepstats swissprot:RACR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RACR_ECOLI pepwheel swissprot:RACR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RACR_ECOLI pepwindow swissprot:RACR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RACR_ECOLI sigcleave swissprot:RACR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RACR_ECOLI ## Database ID URL or Descriptions # BioGrid 4262344 9 # COFACTOR UBII_ECOLI Name=FAD; Xref=ChEBI CHEBI 57692; Evidence={ECO 0000305|PubMed 23709220}; # DISRUPTION PHENOTYPE Cells lacking this gene have a low level of coenzyme Q8 in aerobic conditions, and accumulate a compound derived from the Q biosynthetic pathway which was identified as 3- octaprenyl-4-hydroxyphenol. When grown anaerobically, they have a content of Q8 comparable with that in wild-type cells and do not accumulate 3-octaprenyl-4-hydroxyphenol. The levels of the isoprenoid naphthoquinones, demethylmenaquinone and menaquinone (MK8) are not affected in the deletion mutant under aerobic conditions. {ECO:0000269|PubMed 23709220}. # EcoGene EG11333 visC # FUNCTION UBII_ECOLI FAD-dependent monooxygenase required for the aerobic hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy- phenol, the first hydroxylation step in coenzyme Q (ubiquinone) biosynthesis. {ECO 0000269|PubMed 23709220}. # GO_function GO:0004497 monooxygenase activity; IBA:GO_Central. # GO_function GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; IEA:InterPro. # GO_function GO:0019168 2-octaprenylphenol hydroxylase activity; IMP:EcoCyc. # GO_function GO:0071949 FAD binding; IEA:InterPro. # GO_process GO:0006744 ubiquinone biosynthetic process; IMP:EcoCyc. # GO_process GO:0044550 secondary metabolite biosynthetic process; IBA:GO_Central. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0019748 secondary metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.50.50.60 -; 2. # IntAct P25535 3 # InterPro IPR002938 FAD-bd # InterPro IPR010971 UbiH/COQ6 # InterPro IPR018168 Ubi_Hdrlase_CS # InterPro IPR023753 FAD/NAD-binding_dom # MISCELLANEOUS Partially complements the C5-hydroxylation defect of S.cerevisiae cells lacking COQ6. {ECO:0000305|PubMed 23709220}. # Organism UBII_ECOLI Escherichia coli (strain K12) # PATHWAY Cofactor biosynthesis; ubiquinone biosynthesis. {ECO:0000269|PubMed 23709220}. # PATRIC 32121226 VBIEscCol129921_3001 # PDB 4K22 X-ray; 2.00 A; A/B=1-365 # PIR B65075 B65075 # PROSITE PS01304 UBIH # Pfam PF01494 FAD_binding_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UBII_ECOLI 2-octaprenylphenol hydroxylase # RefSeq NP_417382 NC_000913.3 # RefSeq WP_001192229 NZ_LN832404.1 # SIMILARITY Belongs to the UbiH/COQ6 family. {ECO 0000305}. # SUBUNIT Homotetramer. {ECO:0000305|PubMed 23709220}. # SUPFAM SSF51905 SSF51905; 2 # TIGRFAMs TIGR01988 Ubi-OHases # eggNOG COG0654 LUCA # eggNOG ENOG4105EAK Bacteria BLAST swissprot:UBII_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UBII_ECOLI BioCyc ECOL316407:JW2874-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2874-MONOMER BioCyc EcoCyc:EG11333-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11333-MONOMER BioCyc MetaCyc:EG11333-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11333-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M113.480368 http://dx.doi.org/10.1074/jbc.M113.480368 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.14.13.- http://www.genome.jp/dbget-bin/www_bget?EC:1.14.13.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D90281 http://www.ebi.ac.uk/ena/data/view/D90281 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 ENZYME 1.14.13.- http://enzyme.expasy.org/EC/1.14.13.- EchoBASE EB1309 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1309 EcoGene EG11333 http://www.ecogene.org/geneInfo.php?eg_id=EG11333 EnsemblBacteria AAC75944 http://www.ensemblgenomes.org/id/AAC75944 EnsemblBacteria AAC75944 http://www.ensemblgenomes.org/id/AAC75944 EnsemblBacteria BAE76971 http://www.ensemblgenomes.org/id/BAE76971 EnsemblBacteria BAE76971 http://www.ensemblgenomes.org/id/BAE76971 EnsemblBacteria BAE76971 http://www.ensemblgenomes.org/id/BAE76971 EnsemblBacteria b2906 http://www.ensemblgenomes.org/id/b2906 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004497 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004497 GO_function GO:0016709 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016709 GO_function GO:0019168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019168 GO_function GO:0071949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071949 GO_process GO:0006744 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006744 GO_process GO:0044550 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044550 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0019748 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019748 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 GeneID 947389 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947389 HOGENOM HOG000255771 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000255771&db=HOGENOM6 InParanoid P25535 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P25535 IntAct P25535 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P25535* IntEnz 1.14.13 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.14.13 InterPro IPR002938 http://www.ebi.ac.uk/interpro/entry/IPR002938 InterPro IPR010971 http://www.ebi.ac.uk/interpro/entry/IPR010971 InterPro IPR018168 http://www.ebi.ac.uk/interpro/entry/IPR018168 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 KEGG_Gene ecj:JW2874 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2874 KEGG_Gene eco:b2906 http://www.genome.jp/dbget-bin/www_bget?eco:b2906 OMA DMRLGLC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DMRLGLC PDB 4K22 http://www.ebi.ac.uk/pdbe-srv/view/entry/4K22 PDBsum 4K22 http://www.ebi.ac.uk/pdbsum/4K22 PROSITE PS01304 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01304 PSORT swissprot:UBII_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UBII_ECOLI PSORT-B swissprot:UBII_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UBII_ECOLI PSORT2 swissprot:UBII_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UBII_ECOLI Pfam PF01494 http://pfam.xfam.org/family/PF01494 Phobius swissprot:UBII_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UBII_ECOLI PhylomeDB P25535 http://phylomedb.org/?seqid=P25535 ProteinModelPortal P25535 http://www.proteinmodelportal.org/query/uniprot/P25535 PubMed 1339425 http://www.ncbi.nlm.nih.gov/pubmed/1339425 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 23709220 http://www.ncbi.nlm.nih.gov/pubmed/23709220 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417382 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417382 RefSeq WP_001192229 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001192229 SMR P25535 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P25535 STRING 511145.b2906 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2906&targetmode=cogs SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 TIGRFAMs TIGR01988 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01988 UniProtKB UBII_ECOLI http://www.uniprot.org/uniprot/UBII_ECOLI UniProtKB-AC P25535 http://www.uniprot.org/uniprot/P25535 charge swissprot:UBII_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UBII_ECOLI eggNOG COG0654 http://eggnogapi.embl.de/nog_data/html/tree/COG0654 eggNOG ENOG4105EAK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EAK epestfind swissprot:UBII_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UBII_ECOLI garnier swissprot:UBII_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UBII_ECOLI helixturnhelix swissprot:UBII_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UBII_ECOLI hmoment swissprot:UBII_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UBII_ECOLI iep swissprot:UBII_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UBII_ECOLI inforesidue swissprot:UBII_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UBII_ECOLI octanol swissprot:UBII_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UBII_ECOLI pepcoil swissprot:UBII_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UBII_ECOLI pepdigest swissprot:UBII_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UBII_ECOLI pepinfo swissprot:UBII_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UBII_ECOLI pepnet swissprot:UBII_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UBII_ECOLI pepstats swissprot:UBII_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UBII_ECOLI pepwheel swissprot:UBII_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UBII_ECOLI pepwindow swissprot:UBII_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UBII_ECOLI sigcleave swissprot:UBII_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UBII_ECOLI ## Database ID URL or Descriptions # BioGrid 4262743 3 # COFACTOR SGCX_ECOLI Name=a divalent metal cation; Xref=ChEBI CHEBI 60240; Evidence={ECO 0000250}; Note=Binds 2 divalent metal cations per subunit. {ECO 0000250}; # EcoGene EG12557 sgcX # GO_function GO:0004177 aminopeptidase activity; IEA:UniProtKB-KW. # GO_function GO:0008237 metallopeptidase activity; IEA:UniProtKB-KW. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0043167 ion binding # Gene3D 2.40.30.40 -; 1. # InterPro IPR008007 Peptidase_M42 # InterPro IPR023367 Peptidase_M42_dom2 # Organism SGCX_ECOLI Escherichia coli (strain K12) # PATRIC 32124198 VBIEscCol129921_4442 # PIR C65244 C65244 # PIRSF PIRSF001123 PepA_GA # Pfam PF05343 Peptidase_M42 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SGCX_ECOLI Putative aminopeptidase SgcX # RefSeq NP_418725 NC_000913.3 # RefSeq WP_000010829 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97201.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the peptidase M42 family. {ECO 0000305}. # eggNOG COG1363 LUCA # eggNOG ENOG4105CN9 Bacteria BLAST swissprot:SGCX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SGCX_ECOLI BioCyc ECOL316407:JW5776-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5776-MONOMER BioCyc EcoCyc:SGCB-MONOMER http://biocyc.org/getid?id=EcoCyc:SGCB-MONOMER DIP DIP-10881N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10881N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.11.- http://www.genome.jp/dbget-bin/www_bget?EC:3.4.11.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 3.4.11.- http://enzyme.expasy.org/EC/3.4.11.- EchoBASE EB2445 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2445 EcoGene EG12557 http://www.ecogene.org/geneInfo.php?eg_id=EG12557 EnsemblBacteria AAC77261 http://www.ensemblgenomes.org/id/AAC77261 EnsemblBacteria AAC77261 http://www.ensemblgenomes.org/id/AAC77261 EnsemblBacteria BAE78297 http://www.ensemblgenomes.org/id/BAE78297 EnsemblBacteria BAE78297 http://www.ensemblgenomes.org/id/BAE78297 EnsemblBacteria BAE78297 http://www.ensemblgenomes.org/id/BAE78297 EnsemblBacteria b4305 http://www.ensemblgenomes.org/id/b4305 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004177 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004177 GO_function GO:0008237 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008237 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 2.40.30.40 http://www.cathdb.info/version/latest/superfamily/2.40.30.40 GeneID 948840 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948840 HOGENOM HOG000291972 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000291972&db=HOGENOM6 InParanoid P39366 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39366 IntEnz 3.4.11 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.11 InterPro IPR008007 http://www.ebi.ac.uk/interpro/entry/IPR008007 InterPro IPR023367 http://www.ebi.ac.uk/interpro/entry/IPR023367 KEGG_Gene ecj:JW5776 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5776 KEGG_Gene eco:b4305 http://www.genome.jp/dbget-bin/www_bget?eco:b4305 OMA ICHPTIV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ICHPTIV PSORT swissprot:SGCX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SGCX_ECOLI PSORT-B swissprot:SGCX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SGCX_ECOLI PSORT2 swissprot:SGCX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SGCX_ECOLI Pfam PF05343 http://pfam.xfam.org/family/PF05343 Phobius swissprot:SGCX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SGCX_ECOLI PhylomeDB P39366 http://phylomedb.org/?seqid=P39366 ProteinModelPortal P39366 http://www.proteinmodelportal.org/query/uniprot/P39366 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418725 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418725 RefSeq WP_000010829 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000010829 SMR P39366 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39366 STRING 511145.b4305 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4305&targetmode=cogs UniProtKB SGCX_ECOLI http://www.uniprot.org/uniprot/SGCX_ECOLI UniProtKB-AC P39366 http://www.uniprot.org/uniprot/P39366 charge swissprot:SGCX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SGCX_ECOLI eggNOG COG1363 http://eggnogapi.embl.de/nog_data/html/tree/COG1363 eggNOG ENOG4105CN9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CN9 epestfind swissprot:SGCX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SGCX_ECOLI garnier swissprot:SGCX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SGCX_ECOLI helixturnhelix swissprot:SGCX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SGCX_ECOLI hmoment swissprot:SGCX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SGCX_ECOLI iep swissprot:SGCX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SGCX_ECOLI inforesidue swissprot:SGCX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SGCX_ECOLI octanol swissprot:SGCX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SGCX_ECOLI pepcoil swissprot:SGCX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SGCX_ECOLI pepdigest swissprot:SGCX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SGCX_ECOLI pepinfo swissprot:SGCX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SGCX_ECOLI pepnet swissprot:SGCX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SGCX_ECOLI pepstats swissprot:SGCX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SGCX_ECOLI pepwheel swissprot:SGCX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SGCX_ECOLI pepwindow swissprot:SGCX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SGCX_ECOLI sigcleave swissprot:SGCX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SGCX_ECOLI ## Database ID URL or Descriptions # AltName Phosphoriboisomerase A {ECO:0000255|HAMAP-Rule MF_00170} # BIOPHYSICOCHEMICAL PROPERTIES RPIA_ECOLI Kinetic parameters KM=3.1 mM for ribose-5-phosphate {ECO 0000269|PubMed 12517338}; KM=4.4 mM for D-ribose 5-phosphate (at 37 degrees Celsius) {ECO 0000269|PubMed 1104357}; Note=Kcat is 2100 sec(-1) for ribose-5-phosphate.; Temperature dependence After incubation at 45 degrees Celsius for 30 minutes RpiA retains 90% of its original activities. {ECO 0000269|PubMed 1104357, ECO 0000269|PubMed 12517338}; # BRENDA 5.3.1 2026 # BioGrid 4259674 21 # CATALYTIC ACTIVITY RPIA_ECOLI D-ribose 5-phosphate = D-ribulose 5-phosphate. {ECO 0000255|HAMAP-Rule MF_00170, ECO 0000269|PubMed 1104357, ECO 0000269|PubMed 12517338}. # CDD cd01398 RPI_A # ENZYME REGULATION Inhibited by arabinose-5-phosphate, D- erythrose-4-phosphate and D-erythronic acid. {ECO:0000269|PubMed 12517338}. # EcoGene EG11443 rpiA # FUNCTION RPIA_ECOLI Involved in the first step of the non-oxidative branch of the pentose phosphate pathway. It catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. Can also act on D-ribose-5-diphosphate and D-ribose-5-triphosphate as substrate. {ECO 0000269|PubMed 1104357, ECO 0000269|PubMed 12517338, ECO 0000269|PubMed 4909663}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0004751 ribose-5-phosphate isomerase activity; IDA:EcoCyc. # GO_process GO:0006014 D-ribose metabolic process; IMP:EcoCyc. # GO_process GO:0009052 pentose-phosphate shunt, non-oxidative branch; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0044281 small molecule metabolic process # HAMAP MF_00170 Rib_5P_isom_A # INDUCTION RPIA_ECOLI Constitutively expressed. {ECO 0000269|PubMed 1104357, ECO 0000269|PubMed 11945603, ECO 0000269|PubMed 12517338}. # InterPro IPR004788 Ribose5P_isomerase_typA # InterPro IPR020672 Ribose5P_isomerase_typA_subgr # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00030 Pentose phosphate pathway # KEGG_Pathway ko00710 Carbon fixation in photosynthetic organisms # Organism RPIA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11934 PTHR11934 # PATHWAY Carbohydrate degradation; pentose phosphate pathway; D- ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1. {ECO 0000255|HAMAP-Rule:MF_00170}. # PATRIC 32121242 VBIEscCol129921_3009 # PDB 1KS2 X-ray; 1.50 A; A/B=1-219 # PDB 1LKZ X-ray; 2.50 A; A/B=1-219 # PDB 1O8B X-ray; 1.25 A; A/B=1-219 # PIR A65076 A65076 # Pfam PF06026 Rib_5-P_isom_A # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Ribose-5-phosphate isomerase A {ECO:0000255|HAMAP-Rule MF_00170} # RefSeq NP_417389 NC_000913.3 # RefSeq WP_000189743 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA47309.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ribose 5-phosphate isomerase family. {ECO:0000255|HAMAP-Rule MF_00170}. # SUBUNIT RPIA_ECOLI Homodimer. {ECO 0000255|HAMAP-Rule MF_00170, ECO 0000269|PubMed 12517338}. # TIGRFAMs TIGR00021 rpiA # UniPathway UPA00115 UER00412 # eggNOG COG0120 LUCA # eggNOG ENOG4105E66 Bacteria BLAST swissprot:RPIA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RPIA_ECOLI BioCyc ECOL316407:JW5475-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5475-MONOMER BioCyc EcoCyc:RIB5PISOMA-MONOMER http://biocyc.org/getid?id=EcoCyc:RIB5PISOMA-MONOMER BioCyc MetaCyc:RIB5PISOMA-MONOMER http://biocyc.org/getid?id=MetaCyc:RIB5PISOMA-MONOMER COG COG0120 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0120 DIP DIP-10739N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10739N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1002/prot.10203 http://dx.doi.org/10.1002/prot.10203 DOI 10.1006/jmbi.1998.1726 http://dx.doi.org/10.1006/jmbi.1998.1726 DOI 10.1016/0014-5793(71)80202-8 http://dx.doi.org/10.1016/0014-5793(71)80202-8 DOI 10.1016/S0969-2126(02)00933-4 http://dx.doi.org/10.1016/S0969-2126(02)00933-4 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1432-1033.1975.tb02166.x http://dx.doi.org/10.1111/j.1432-1033.1975.tb02166.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.3.1.6 {ECO:0000255|HAMAP-Rule:MF_00170} http://www.genome.jp/dbget-bin/www_bget?EC:5.3.1.6 {ECO:0000255|HAMAP-Rule:MF_00170} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M64630 http://www.ebi.ac.uk/ena/data/view/M64630 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EMBL X66836 http://www.ebi.ac.uk/ena/data/view/X66836 EMBL X73026 http://www.ebi.ac.uk/ena/data/view/X73026 ENZYME 5.3.1.6 {ECO:0000255|HAMAP-Rule:MF_00170} http://enzyme.expasy.org/EC/5.3.1.6 {ECO:0000255|HAMAP-Rule:MF_00170} EchoBASE EB1413 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1413 EcoGene EG11443 http://www.ecogene.org/geneInfo.php?eg_id=EG11443 EnsemblBacteria AAC75951 http://www.ensemblgenomes.org/id/AAC75951 EnsemblBacteria AAC75951 http://www.ensemblgenomes.org/id/AAC75951 EnsemblBacteria BAE76978 http://www.ensemblgenomes.org/id/BAE76978 EnsemblBacteria BAE76978 http://www.ensemblgenomes.org/id/BAE76978 EnsemblBacteria BAE76978 http://www.ensemblgenomes.org/id/BAE76978 EnsemblBacteria b2914 http://www.ensemblgenomes.org/id/b2914 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004751 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004751 GO_process GO:0006014 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006014 GO_process GO:0009052 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009052 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 947407 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947407 HAMAP MF_00170 http://hamap.expasy.org/unirule/MF_00170 HOGENOM HOG000276368 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276368&db=HOGENOM6 InParanoid P0A7Z0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7Z0 IntEnz 5.3.1.6 {ECO:0000255|HAMAP-Rule:MF_00170} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.3.1.6 {ECO:0000255|HAMAP-Rule:MF_00170} InterPro IPR004788 http://www.ebi.ac.uk/interpro/entry/IPR004788 InterPro IPR020672 http://www.ebi.ac.uk/interpro/entry/IPR020672 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5475 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5475 KEGG_Gene eco:b2914 http://www.genome.jp/dbget-bin/www_bget?eco:b2914 KEGG_Orthology KO:K01807 http://www.genome.jp/dbget-bin/www_bget?KO:K01807 KEGG_Pathway ko00030 http://www.genome.jp/kegg-bin/show_pathway?ko00030 KEGG_Pathway ko00710 http://www.genome.jp/kegg-bin/show_pathway?ko00710 KEGG_Reaction rn:R01056 http://www.genome.jp/dbget-bin/www_bget?rn:R01056 OMA GACHVQE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GACHVQE PANTHER PTHR11934 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11934 PDB 1KS2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1KS2 PDB 1LKZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1LKZ PDB 1O8B http://www.ebi.ac.uk/pdbe-srv/view/entry/1O8B PDBsum 1KS2 http://www.ebi.ac.uk/pdbsum/1KS2 PDBsum 1LKZ http://www.ebi.ac.uk/pdbsum/1LKZ PDBsum 1O8B http://www.ebi.ac.uk/pdbsum/1O8B PSORT swissprot:RPIA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RPIA_ECOLI PSORT-B swissprot:RPIA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RPIA_ECOLI PSORT2 swissprot:RPIA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RPIA_ECOLI Pfam PF06026 http://pfam.xfam.org/family/PF06026 Phobius swissprot:RPIA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RPIA_ECOLI PhylomeDB P0A7Z0 http://phylomedb.org/?seqid=P0A7Z0 ProteinModelPortal P0A7Z0 http://www.proteinmodelportal.org/query/uniprot/P0A7Z0 PubMed 1104357 http://www.ncbi.nlm.nih.gov/pubmed/1104357 PubMed 11945603 http://www.ncbi.nlm.nih.gov/pubmed/11945603 PubMed 12211039 http://www.ncbi.nlm.nih.gov/pubmed/12211039 PubMed 12517338 http://www.ncbi.nlm.nih.gov/pubmed/12517338 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1917830 http://www.ncbi.nlm.nih.gov/pubmed/1917830 PubMed 4909663 http://www.ncbi.nlm.nih.gov/pubmed/4909663 PubMed 8366047 http://www.ncbi.nlm.nih.gov/pubmed/8366047 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 RefSeq NP_417389 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417389 RefSeq WP_000189743 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000189743 SMR P0A7Z0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7Z0 STRING 511145.b2914 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2914&targetmode=cogs STRING COG0120 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0120&targetmode=cogs SWISS-2DPAGE P0A7Z0 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A7Z0 TIGRFAMs TIGR00021 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00021 UniProtKB RPIA_ECOLI http://www.uniprot.org/uniprot/RPIA_ECOLI UniProtKB-AC P0A7Z0 http://www.uniprot.org/uniprot/P0A7Z0 charge swissprot:RPIA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RPIA_ECOLI eggNOG COG0120 http://eggnogapi.embl.de/nog_data/html/tree/COG0120 eggNOG ENOG4105E66 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E66 epestfind swissprot:RPIA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RPIA_ECOLI garnier swissprot:RPIA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RPIA_ECOLI helixturnhelix swissprot:RPIA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RPIA_ECOLI hmoment swissprot:RPIA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RPIA_ECOLI iep swissprot:RPIA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RPIA_ECOLI inforesidue swissprot:RPIA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RPIA_ECOLI octanol swissprot:RPIA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RPIA_ECOLI pepcoil swissprot:RPIA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RPIA_ECOLI pepdigest swissprot:RPIA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RPIA_ECOLI pepinfo swissprot:RPIA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RPIA_ECOLI pepnet swissprot:RPIA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RPIA_ECOLI pepstats swissprot:RPIA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RPIA_ECOLI pepwheel swissprot:RPIA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RPIA_ECOLI pepwindow swissprot:RPIA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RPIA_ECOLI sigcleave swissprot:RPIA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RPIA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259638 396 # EcoGene EG12502 ytfB # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # IntAct P39310 2 # InterPro IPR007340 Opacity-associatedA # InterPro IPR013731 OapA_N # Organism YTFB_ECOLI Escherichia coli (strain K12) # PATRIC 32123987 VBIEscCol129921_4338 # PIR S56431 S56431 # Pfam PF04225 OapA # Pfam PF08525 OapA_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YTFB_ECOLI Uncharacterized protein YtfB # RefSeq NP_418627 NC_000913.3 # RefSeq WP_001119478 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97102.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SUBCELLULAR LOCATION YTFB_ECOLI Membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. # eggNOG COG3061 LUCA # eggNOG ENOG4105FHY Bacteria BLAST swissprot:YTFB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YTFB_ECOLI BioCyc ECOL316407:JW5745-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5745-MONOMER BioCyc EcoCyc:G7864-MONOMER http://biocyc.org/getid?id=EcoCyc:G7864-MONOMER COG COG3061 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3061 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2395 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2395 EcoGene EG12502 http://www.ecogene.org/geneInfo.php?eg_id=EG12502 EnsemblBacteria AAC77163 http://www.ensemblgenomes.org/id/AAC77163 EnsemblBacteria AAC77163 http://www.ensemblgenomes.org/id/AAC77163 EnsemblBacteria BAE78207 http://www.ensemblgenomes.org/id/BAE78207 EnsemblBacteria BAE78207 http://www.ensemblgenomes.org/id/BAE78207 EnsemblBacteria BAE78207 http://www.ensemblgenomes.org/id/BAE78207 EnsemblBacteria b4206 http://www.ensemblgenomes.org/id/b4206 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GeneID 948727 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948727 HOGENOM HOG000127418 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000127418&db=HOGENOM6 IntAct P39310 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39310* InterPro IPR007340 http://www.ebi.ac.uk/interpro/entry/IPR007340 InterPro IPR013731 http://www.ebi.ac.uk/interpro/entry/IPR013731 KEGG_Gene ecj:JW5745 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5745 KEGG_Gene eco:b4206 http://www.genome.jp/dbget-bin/www_bget?eco:b4206 KEGG_Orthology KO:K07269 http://www.genome.jp/dbget-bin/www_bget?KO:K07269 OMA DHNLPPT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DHNLPPT PSORT swissprot:YTFB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YTFB_ECOLI PSORT-B swissprot:YTFB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YTFB_ECOLI PSORT2 swissprot:YTFB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YTFB_ECOLI Pfam PF04225 http://pfam.xfam.org/family/PF04225 Pfam PF08525 http://pfam.xfam.org/family/PF08525 Phobius swissprot:YTFB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YTFB_ECOLI ProteinModelPortal P39310 http://www.proteinmodelportal.org/query/uniprot/P39310 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418627 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418627 RefSeq WP_001119478 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001119478 STRING 511145.b4206 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4206&targetmode=cogs STRING COG3061 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3061&targetmode=cogs UniProtKB YTFB_ECOLI http://www.uniprot.org/uniprot/YTFB_ECOLI UniProtKB-AC P39310 http://www.uniprot.org/uniprot/P39310 charge swissprot:YTFB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YTFB_ECOLI eggNOG COG3061 http://eggnogapi.embl.de/nog_data/html/tree/COG3061 eggNOG ENOG4105FHY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FHY epestfind swissprot:YTFB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YTFB_ECOLI garnier swissprot:YTFB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YTFB_ECOLI helixturnhelix swissprot:YTFB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YTFB_ECOLI hmoment swissprot:YTFB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YTFB_ECOLI iep swissprot:YTFB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YTFB_ECOLI inforesidue swissprot:YTFB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YTFB_ECOLI octanol swissprot:YTFB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YTFB_ECOLI pepcoil swissprot:YTFB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YTFB_ECOLI pepdigest swissprot:YTFB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YTFB_ECOLI pepinfo swissprot:YTFB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YTFB_ECOLI pepnet swissprot:YTFB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YTFB_ECOLI pepstats swissprot:YTFB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YTFB_ECOLI pepwheel swissprot:YTFB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YTFB_ECOLI pepwindow swissprot:YTFB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YTFB_ECOLI sigcleave swissprot:YTFB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YTFB_ECOLI ## Database ID URL or Descriptions # AltName PAT_ECOLI Putrescine--2-oxoglutaric acid transaminase # BIOPHYSICOCHEMICAL PROPERTIES PAT_ECOLI Kinetic parameters KM=9.2 mM for putrescine {ECO 0000269|PubMed 12617754}; KM=19.0 mM for 2-oxoglutarate {ECO 0000269|PubMed 12617754}; Note=The kinetic constants are determined for the recombinant His(6)-tagged protein and seem to be 3-4 times lower for the native enzyme.; pH dependence Optimum pH is 9.0. Active at alkaline pH. {ECO 0000269|PubMed 12617754}; Temperature dependence Optimum temperature is 60 degrees Celsius. Highly active from 20 to 80 degrees Celsius. {ECO 0000269|PubMed 12617754}; # BRENDA 2.6.1.82 2026 # BioGrid 4262398 13 # CATALYTIC ACTIVITY PAT_ECOLI Putrescine + 2-oxoglutarate = L-glutamate + 1- pyrroline + H(2)O. # CDD cd00610 OAT_like # COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI 597326; Evidence={ECO:0000305}; # EcoGene EG12718 patA # FUNCTION PAT_ECOLI Catalyzes the aminotransferase reaction from putrescine to 2-oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. Is also able to transaminate cadaverine and, in lower extent, spermidine, but not ornithine. Alpha-ketobutyrate and pyruvate can also act as amino acceptors, although much less efficiently. {ECO 0000269|PubMed 12617754}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0030170 pyridoxal phosphate binding; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IBA:GO_Central. # GO_function PAT_ECOLI GO 0033094 butane-1,4-diamine 2-oxoglutarate aminotransferase activity; IDA EcoCyc. # GO_process GO:0009447 putrescine catabolic process; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.640.10 -; 1. # Gene3D 3.90.1150.10 -; 1. # HAMAP MF_01276 Putres_aminotrans_3 # INDUCTION Up-regulated under nitrogen starvation conditions. Expression is sigma-54-dependent. {ECO:0000269|PubMed 12617754}. # InterPro IPR005814 Aminotrans_3 # InterPro IPR015421 PyrdxlP-dep_Trfase_major_sub1 # InterPro IPR015422 PyrdxlP-dep_Trfase_major_sub2 # InterPro IPR015424 PyrdxlP-dep_Trfase # InterPro IPR017747 Putrescine_aminotransferase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01007 Amino acid related enzymes # KEGG_Pathway ko00330 Arginine and proline metabolism # Organism PAT_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11986 PTHR11986 # PATHWAY Amine and polyamine degradation; putrescine degradation; 4-aminobutanal from putrescine (transaminase route) step 1/1. # PATRIC 32121562 VBIEscCol129921_3167 # PDB 4UOX X-ray; 2.08 A; A/B/C/D=1-459 # PDB 4UOY X-ray; 2.30 A; A/B/C/D=1-459 # PIR F65095 F65095 # PROSITE PS00600 AA_TRANSFER_CLASS_3 # Pfam PF00202 Aminotran_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PAT_ECOLI Putrescine aminotransferase # RefSeq NP_417544 NC_000913.3 # RefSeq WP_001301395 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA57874.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAA89152.1; Type=Erroneous initiation; Evidence={ECO 0000305}; Sequence=BAE77123.1; Type=Erroneous initiation; Evidence={ECO:0000305}; # SIMILARITY Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. Putrescine aminotransferase subfamily. {ECO 0000305}. # SUPFAM SSF53383 SSF53383 # TIGRFAMs TIGR03372 putres_am_tran # UniPathway UPA00188 UER00290 # eggNOG COG4992 LUCA # eggNOG ENOG4105C8Y Bacteria BLAST swissprot:PAT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PAT_ECOLI BioCyc ECOL316407:JW5510-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5510-MONOMER BioCyc EcoCyc:G7596-MONOMER http://biocyc.org/getid?id=EcoCyc:G7596-MONOMER BioCyc MetaCyc:G7596-MONOMER http://biocyc.org/getid?id=MetaCyc:G7596-MONOMER COG COG4992 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4992 DIP DIP-12233N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12233N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1186/1471-2180-3-2 http://dx.doi.org/10.1186/1471-2180-3-2 EC_number EC:2.6.1.82 http://www.genome.jp/dbget-bin/www_bget?EC:2.6.1.82 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL U28379 http://www.ebi.ac.uk/ena/data/view/U28379 ENZYME 2.6.1.82 http://enzyme.expasy.org/EC/2.6.1.82 EchoBASE EB2577 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2577 EcoGene EG12718 http://www.ecogene.org/geneInfo.php?eg_id=EG12718 EnsemblBacteria AAC76108 http://www.ensemblgenomes.org/id/AAC76108 EnsemblBacteria AAC76108 http://www.ensemblgenomes.org/id/AAC76108 EnsemblBacteria BAE77123 http://www.ensemblgenomes.org/id/BAE77123 EnsemblBacteria BAE77123 http://www.ensemblgenomes.org/id/BAE77123 EnsemblBacteria BAE77123 http://www.ensemblgenomes.org/id/BAE77123 EnsemblBacteria b3073 http://www.ensemblgenomes.org/id/b3073 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_function GO:0033094 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033094 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0009447 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009447 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.640.10 http://www.cathdb.info/version/latest/superfamily/3.40.640.10 Gene3D 3.90.1150.10 http://www.cathdb.info/version/latest/superfamily/3.90.1150.10 GeneID 947120 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947120 HAMAP MF_01276 http://hamap.expasy.org/unirule/MF_01276 HOGENOM HOG000020206 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000020206&db=HOGENOM6 InParanoid P42588 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P42588 IntAct P42588 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P42588* IntEnz 2.6.1.82 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.6.1.82 InterPro IPR005814 http://www.ebi.ac.uk/interpro/entry/IPR005814 InterPro IPR015421 http://www.ebi.ac.uk/interpro/entry/IPR015421 InterPro IPR015422 http://www.ebi.ac.uk/interpro/entry/IPR015422 InterPro IPR015424 http://www.ebi.ac.uk/interpro/entry/IPR015424 InterPro IPR017747 http://www.ebi.ac.uk/interpro/entry/IPR017747 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Gene ecj:JW5510 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5510 KEGG_Gene eco:b3073 http://www.genome.jp/dbget-bin/www_bget?eco:b3073 KEGG_Orthology KO:K09251 http://www.genome.jp/dbget-bin/www_bget?KO:K09251 KEGG_Pathway ko00330 http://www.genome.jp/kegg-bin/show_pathway?ko00330 KEGG_Reaction rn:R01155 http://www.genome.jp/dbget-bin/www_bget?rn:R01155 MINT MINT-7290863 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-7290863 OMA THDHTIR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=THDHTIR PANTHER PTHR11986 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11986 PDB 4UOX http://www.ebi.ac.uk/pdbe-srv/view/entry/4UOX PDB 4UOY http://www.ebi.ac.uk/pdbe-srv/view/entry/4UOY PDBsum 4UOX http://www.ebi.ac.uk/pdbsum/4UOX PDBsum 4UOY http://www.ebi.ac.uk/pdbsum/4UOY PROSITE PS00600 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00600 PSORT swissprot:PAT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PAT_ECOLI PSORT-B swissprot:PAT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PAT_ECOLI PSORT2 swissprot:PAT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PAT_ECOLI Pfam PF00202 http://pfam.xfam.org/family/PF00202 Phobius swissprot:PAT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PAT_ECOLI PhylomeDB P42588 http://phylomedb.org/?seqid=P42588 ProteinModelPortal P42588 http://www.proteinmodelportal.org/query/uniprot/P42588 PubMed 12617754 http://www.ncbi.nlm.nih.gov/pubmed/12617754 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417544 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417544 RefSeq WP_001301395 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001301395 SMR P42588 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P42588 STRING 511145.b3073 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3073&targetmode=cogs STRING COG4992 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4992&targetmode=cogs SUPFAM SSF53383 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53383 TIGRFAMs TIGR03372 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03372 UniProtKB PAT_ECOLI http://www.uniprot.org/uniprot/PAT_ECOLI UniProtKB-AC P42588 http://www.uniprot.org/uniprot/P42588 charge swissprot:PAT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PAT_ECOLI eggNOG COG4992 http://eggnogapi.embl.de/nog_data/html/tree/COG4992 eggNOG ENOG4105C8Y http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C8Y epestfind swissprot:PAT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PAT_ECOLI garnier swissprot:PAT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PAT_ECOLI helixturnhelix swissprot:PAT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PAT_ECOLI hmoment swissprot:PAT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PAT_ECOLI iep swissprot:PAT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PAT_ECOLI inforesidue swissprot:PAT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PAT_ECOLI octanol swissprot:PAT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PAT_ECOLI pepcoil swissprot:PAT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PAT_ECOLI pepdigest swissprot:PAT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PAT_ECOLI pepinfo swissprot:PAT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PAT_ECOLI pepnet swissprot:PAT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PAT_ECOLI pepstats swissprot:PAT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PAT_ECOLI pepwheel swissprot:PAT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PAT_ECOLI pepwindow swissprot:PAT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PAT_ECOLI sigcleave swissprot:PAT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PAT_ECOLI ## Database ID URL or Descriptions # EcoGene EG12910 frlC # FUNCTION FRLC_ECOLI Not clear, may be involved in an isomerization step. # GO_function GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0046348 amino sugar catabolic process; IDA:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0009056 catabolic process # Gene3D 3.20.20.150 -; 1. # InterPro IPR013022 Xyl_isomerase-like_TIM-brl # Organism FRLC_ECOLI Escherichia coli (strain K12) # PATHWAY FRLC_ECOLI Carbohydrate metabolism; fructoselysine degradation. # PATRIC 32122178 VBIEscCol129921_3466 # PIR H65131 H65131 # Pfam PF01261 AP_endonuc_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FRLC_ECOLI Protein FrlC # RefSeq WP_000847837 NZ_LN832404.1 # RefSeq YP_026213 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA58169.1; Type=Frameshift; Positions=112; Evidence={ECO:0000305}; Sequence=AAA58170.1; Type=Frameshift; Positions=112; Evidence={ECO 0000305}; # SUPFAM SSF51658 SSF51658 # eggNOG COG1082 LUCA # eggNOG ENOG4107Y0V Bacteria BLAST swissprot:FRLC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FRLC_ECOLI BioCyc ECOL316407:JW5699-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5699-MONOMER BioCyc EcoCyc:G7724-MONOMER http://biocyc.org/getid?id=EcoCyc:G7724-MONOMER BioCyc MetaCyc:G7724-MONOMER http://biocyc.org/getid?id=MetaCyc:G7724-MONOMER COG COG1082 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1082 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M200863200 http://dx.doi.org/10.1074/jbc.M200863200 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2747 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2747 EcoGene EG12910 http://www.ecogene.org/geneInfo.php?eg_id=EG12910 EnsemblBacteria AAT48177 http://www.ensemblgenomes.org/id/AAT48177 EnsemblBacteria AAT48177 http://www.ensemblgenomes.org/id/AAT48177 EnsemblBacteria BAE77918 http://www.ensemblgenomes.org/id/BAE77918 EnsemblBacteria BAE77918 http://www.ensemblgenomes.org/id/BAE77918 EnsemblBacteria BAE77918 http://www.ensemblgenomes.org/id/BAE77918 EnsemblBacteria b4474 http://www.ensemblgenomes.org/id/b4474 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016857 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0046348 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046348 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 3.20.20.150 http://www.cathdb.info/version/latest/superfamily/3.20.20.150 GeneID 2847758 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2847758 HOGENOM HOG000005027 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000005027&db=HOGENOM6 InParanoid P45541 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45541 IntAct P45541 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45541* InterPro IPR013022 http://www.ebi.ac.uk/interpro/entry/IPR013022 KEGG_Gene ecj:JW5699 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5699 KEGG_Gene eco:b4474 http://www.genome.jp/dbget-bin/www_bget?eco:b4474 KEGG_Orthology KO:K10709 http://www.genome.jp/dbget-bin/www_bget?KO:K10709 OMA TRHIHIE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TRHIHIE PSORT swissprot:FRLC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FRLC_ECOLI PSORT-B swissprot:FRLC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FRLC_ECOLI PSORT2 swissprot:FRLC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FRLC_ECOLI Pfam PF01261 http://pfam.xfam.org/family/PF01261 Phobius swissprot:FRLC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FRLC_ECOLI PhylomeDB P45541 http://phylomedb.org/?seqid=P45541 ProteinModelPortal P45541 http://www.proteinmodelportal.org/query/uniprot/P45541 PubMed 12147680 http://www.ncbi.nlm.nih.gov/pubmed/12147680 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000847837 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000847837 RefSeq YP_026213 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026213 SMR P45541 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45541 STRING 511145.b4474 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4474&targetmode=cogs STRING COG1082 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1082&targetmode=cogs SUPFAM SSF51658 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51658 UniProtKB FRLC_ECOLI http://www.uniprot.org/uniprot/FRLC_ECOLI UniProtKB-AC P45541 http://www.uniprot.org/uniprot/P45541 charge swissprot:FRLC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FRLC_ECOLI eggNOG COG1082 http://eggnogapi.embl.de/nog_data/html/tree/COG1082 eggNOG ENOG4107Y0V http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107Y0V epestfind swissprot:FRLC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FRLC_ECOLI garnier swissprot:FRLC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FRLC_ECOLI helixturnhelix swissprot:FRLC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FRLC_ECOLI hmoment swissprot:FRLC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FRLC_ECOLI iep swissprot:FRLC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FRLC_ECOLI inforesidue swissprot:FRLC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FRLC_ECOLI octanol swissprot:FRLC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FRLC_ECOLI pepcoil swissprot:FRLC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FRLC_ECOLI pepdigest swissprot:FRLC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FRLC_ECOLI pepinfo swissprot:FRLC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FRLC_ECOLI pepnet swissprot:FRLC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FRLC_ECOLI pepstats swissprot:FRLC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FRLC_ECOLI pepwheel swissprot:FRLC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FRLC_ECOLI pepwindow swissprot:FRLC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FRLC_ECOLI sigcleave swissprot:FRLC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FRLC_ECOLI ## Database ID URL or Descriptions # AltName URK_ECOLI Cytidine monophosphokinase # AltName URK_ECOLI Uridine monophosphokinase # BioGrid 4259683 7 # CATALYTIC ACTIVITY URK_ECOLI ATP + cytidine = ADP + CMP. # CATALYTIC ACTIVITY URK_ECOLI ATP + uridine = ADP + UMP. # EcoGene EG11701 udk # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004849 uridine kinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0043771 cytidine kinase activity; IDA:EcoCyc. # GO_process GO:0006206 pyrimidine nucleobase metabolic process; IBA:GO_Central. # GO_process GO:0043097 pyrimidine nucleoside salvage; IBA:GO_Central. # GO_process GO:0044206 UMP salvage; IEA:UniProtKB-UniPathway. # GO_process GO:0044211 CTP salvage; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.300 -; 1. # HAMAP MF_00551 Uridine_kinase # IntAct P0A8F4 12 # InterPro IPR000764 Uridine_kinase-like # InterPro IPR006083 PRK/URK # InterPro IPR026008 Uridine_kinase_ # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00240 Pyrimidine metabolism # KEGG_Pathway ko00983 Drug metabolism - other enzymes # Organism URK_ECOLI Escherichia coli (strain K12) # PATHWAY Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine step 1/3. # PATHWAY Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine step 1/1. # PATRIC 32119465 VBIEscCol129921_2143 # PIR A64973 A64973 # PRINTS PR00988 URIDINKINASE # Pfam PF00485 PRK # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName URK_ECOLI Uridine kinase # RefSeq NP_416570 NC_000913.3 # RefSeq WP_001295424 NZ_LN832404.1 # SIMILARITY Belongs to the uridine kinase family. {ECO 0000305}. # SUBCELLULAR LOCATION URK_ECOLI Cytoplasm. # SUBUNIT URK_ECOLI Homotetramer. # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR00235 udk # UniPathway UPA00574 UER00637 # UniPathway UPA00579 UER00640 # eggNOG COG0572 LUCA # eggNOG ENOG4105DBI Bacteria BLAST swissprot:URK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:URK_ECOLI BioCyc ECOL316407:JW2051-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2051-MONOMER BioCyc EcoCyc:UDK-MONOMER http://biocyc.org/getid?id=EcoCyc:UDK-MONOMER BioCyc MetaCyc:UDK-MONOMER http://biocyc.org/getid?id=MetaCyc:UDK-MONOMER COG COG0572 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0572 DIP DIP-36012N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36012N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.48 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.48 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X71492 http://www.ebi.ac.uk/ena/data/view/X71492 ENZYME 2.7.1.48 http://enzyme.expasy.org/EC/2.7.1.48 EchoBASE EB1652 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1652 EcoGene EG11701 http://www.ecogene.org/geneInfo.php?eg_id=EG11701 EnsemblBacteria AAC75127 http://www.ensemblgenomes.org/id/AAC75127 EnsemblBacteria AAC75127 http://www.ensemblgenomes.org/id/AAC75127 EnsemblBacteria BAA15919 http://www.ensemblgenomes.org/id/BAA15919 EnsemblBacteria BAA15919 http://www.ensemblgenomes.org/id/BAA15919 EnsemblBacteria BAA15919 http://www.ensemblgenomes.org/id/BAA15919 EnsemblBacteria b2066 http://www.ensemblgenomes.org/id/b2066 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004849 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004849 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0043771 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043771 GO_process GO:0006206 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006206 GO_process GO:0043097 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043097 GO_process GO:0044206 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044206 GO_process GO:0044211 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044211 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 946597 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946597 HAMAP MF_00551 http://hamap.expasy.org/unirule/MF_00551 HOGENOM HOG000262756 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000262756&db=HOGENOM6 InParanoid P0A8F4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8F4 IntAct P0A8F4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8F4* IntEnz 2.7.1.48 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.48 InterPro IPR000764 http://www.ebi.ac.uk/interpro/entry/IPR000764 InterPro IPR006083 http://www.ebi.ac.uk/interpro/entry/IPR006083 InterPro IPR026008 http://www.ebi.ac.uk/interpro/entry/IPR026008 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2051 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2051 KEGG_Gene eco:b2066 http://www.genome.jp/dbget-bin/www_bget?eco:b2066 KEGG_Orthology KO:K00876 http://www.genome.jp/dbget-bin/www_bget?KO:K00876 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Pathway ko00983 http://www.genome.jp/kegg-bin/show_pathway?ko00983 KEGG_Reaction rn:R00513 http://www.genome.jp/dbget-bin/www_bget?rn:R00513 KEGG_Reaction rn:R00516 http://www.genome.jp/dbget-bin/www_bget?rn:R00516 KEGG_Reaction rn:R00517 http://www.genome.jp/dbget-bin/www_bget?rn:R00517 KEGG_Reaction rn:R00962 http://www.genome.jp/dbget-bin/www_bget?rn:R00962 KEGG_Reaction rn:R00964 http://www.genome.jp/dbget-bin/www_bget?rn:R00964 KEGG_Reaction rn:R00967 http://www.genome.jp/dbget-bin/www_bget?rn:R00967 KEGG_Reaction rn:R00968 http://www.genome.jp/dbget-bin/www_bget?rn:R00968 KEGG_Reaction rn:R00970 http://www.genome.jp/dbget-bin/www_bget?rn:R00970 KEGG_Reaction rn:R01548 http://www.genome.jp/dbget-bin/www_bget?rn:R01548 KEGG_Reaction rn:R01549 http://www.genome.jp/dbget-bin/www_bget?rn:R01549 KEGG_Reaction rn:R01880 http://www.genome.jp/dbget-bin/www_bget?rn:R01880 KEGG_Reaction rn:R02091 http://www.genome.jp/dbget-bin/www_bget?rn:R02091 KEGG_Reaction rn:R02096 http://www.genome.jp/dbget-bin/www_bget?rn:R02096 KEGG_Reaction rn:R02097 http://www.genome.jp/dbget-bin/www_bget?rn:R02097 KEGG_Reaction rn:R02327 http://www.genome.jp/dbget-bin/www_bget?rn:R02327 KEGG_Reaction rn:R02332 http://www.genome.jp/dbget-bin/www_bget?rn:R02332 KEGG_Reaction rn:R02371 http://www.genome.jp/dbget-bin/www_bget?rn:R02371 KEGG_Reaction rn:R02372 http://www.genome.jp/dbget-bin/www_bget?rn:R02372 KEGG_Reaction rn:R08232 http://www.genome.jp/dbget-bin/www_bget?rn:R08232 OMA EHTRTTE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EHTRTTE PRINTS PR00988 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00988 PSORT swissprot:URK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:URK_ECOLI PSORT-B swissprot:URK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:URK_ECOLI PSORT2 swissprot:URK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:URK_ECOLI Pfam PF00485 http://pfam.xfam.org/family/PF00485 Phobius swissprot:URK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:URK_ECOLI PhylomeDB P0A8F4 http://phylomedb.org/?seqid=P0A8F4 ProteinModelPortal P0A8F4 http://www.proteinmodelportal.org/query/uniprot/P0A8F4 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8366067 http://www.ncbi.nlm.nih.gov/pubmed/8366067 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416570 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416570 RefSeq WP_001295424 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295424 SMR P0A8F4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8F4 STRING 511145.b2066 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2066&targetmode=cogs STRING COG0572 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0572&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR00235 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00235 UniProtKB URK_ECOLI http://www.uniprot.org/uniprot/URK_ECOLI UniProtKB-AC P0A8F4 http://www.uniprot.org/uniprot/P0A8F4 charge swissprot:URK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:URK_ECOLI eggNOG COG0572 http://eggnogapi.embl.de/nog_data/html/tree/COG0572 eggNOG ENOG4105DBI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DBI epestfind swissprot:URK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:URK_ECOLI garnier swissprot:URK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:URK_ECOLI helixturnhelix swissprot:URK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:URK_ECOLI hmoment swissprot:URK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:URK_ECOLI iep swissprot:URK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:URK_ECOLI inforesidue swissprot:URK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:URK_ECOLI octanol swissprot:URK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:URK_ECOLI pepcoil swissprot:URK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:URK_ECOLI pepdigest swissprot:URK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:URK_ECOLI pepinfo swissprot:URK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:URK_ECOLI pepnet swissprot:URK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:URK_ECOLI pepstats swissprot:URK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:URK_ECOLI pepwheel swissprot:URK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:URK_ECOLI pepwindow swissprot:URK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:URK_ECOLI sigcleave swissprot:URK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:URK_ECOLI ## Database ID URL or Descriptions # BioGrid 4263179 213 # CDD cd06174 MFS # EcoGene EG11439 emrB # FUNCTION EMRB_ECOLI Part of the tripartite efflux system EmrAB-TolC, which confers resistance to antibiotics such as CCCP, FCCP, 2,4- dinitrophenol and nalidixic acid. {ECO 0000269|PubMed 12482849, ECO 0000269|PubMed 1409590}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0009636 response to toxic substance; IMP:EcoCyc. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GO_process GO:0055085 transmembrane transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0008150 biological_process # GOslim_process GO:0055085 transmembrane transport # InterPro IPR004638 Drug-R_transpt_efflux_EmrB # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # KEGG_Brite ko02000 Transporters # Organism EMRB_ECOLI Escherichia coli (strain K12) # PATRIC 32120766 VBIEscCol129921_2780 # PIR G65048 G65048 # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EMRB_ECOLI Multidrug export protein EmrB # RefSeq NP_417171 NC_000913.3 # RefSeq WP_001295176 NZ_LN832404.1 # SIMILARITY Belongs to the major facilitator superfamily. EmrB family. {ECO 0000305}. # SUBCELLULAR LOCATION EMRB_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # SUBUNIT EMRB_ECOLI Part of the tripartite efflux system EmrAB-TolC, which is composed of an inner membrane transporter, EmrB, a periplasmic membrane fusion protein, EmrA, and an outer membrane component, TolC. The complex forms a large protein conduit and can translocate molecules across both the inner and outer membranes. Interacts with EmrA. EmrAB complex forms a dimer in vitro. {ECO 0000269|PubMed 12482849, ECO 0000269|PubMed 19171121}. # SUPFAM SSF103473 SSF103473; 3 # TCDB 2.A.1.3 the major facilitator superfamily (mfs) # TIGRFAMs TIGR00711 efflux_EmrB # eggNOG ENOG4105C0R Bacteria # eggNOG ENOG410XNN3 LUCA BLAST swissprot:EMRB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EMRB_ECOLI BioCyc ECOL316407:JW2661-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2661-MONOMER BioCyc EcoCyc:EMRB-MONOMER http://biocyc.org/getid?id=EcoCyc:EMRB-MONOMER COG COG0477 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0477 DOI 10.1016/j.bbrc.2009.01.081 http://dx.doi.org/10.1016/j.bbrc.2009.01.081 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.89.19.8938 http://dx.doi.org/10.1073/pnas.89.19.8938 DOI 10.1074/jbc.M209457200 http://dx.doi.org/10.1074/jbc.M209457200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M86657 http://www.ebi.ac.uk/ena/data/view/M86657 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1409 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1409 EcoGene EG11439 http://www.ecogene.org/geneInfo.php?eg_id=EG11439 EnsemblBacteria AAC75733 http://www.ensemblgenomes.org/id/AAC75733 EnsemblBacteria AAC75733 http://www.ensemblgenomes.org/id/AAC75733 EnsemblBacteria BAA16548 http://www.ensemblgenomes.org/id/BAA16548 EnsemblBacteria BAA16548 http://www.ensemblgenomes.org/id/BAA16548 EnsemblBacteria BAA16548 http://www.ensemblgenomes.org/id/BAA16548 EnsemblBacteria b2686 http://www.ensemblgenomes.org/id/b2686 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0009636 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009636 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 947167 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947167 HOGENOM HOG000112190 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000112190&db=HOGENOM6 InParanoid P0AEJ0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEJ0 InterPro IPR004638 http://www.ebi.ac.uk/interpro/entry/IPR004638 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2661 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2661 KEGG_Gene eco:b2686 http://www.genome.jp/dbget-bin/www_bget?eco:b2686 KEGG_Orthology KO:K03446 http://www.genome.jp/dbget-bin/www_bget?KO:K03446 OMA VSNSLNM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VSNSLNM PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:EMRB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EMRB_ECOLI PSORT-B swissprot:EMRB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EMRB_ECOLI PSORT2 swissprot:EMRB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EMRB_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:EMRB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EMRB_ECOLI PhylomeDB P0AEJ0 http://phylomedb.org/?seqid=P0AEJ0 ProteinModelPortal P0AEJ0 http://www.proteinmodelportal.org/query/uniprot/P0AEJ0 PubMed 12482849 http://www.ncbi.nlm.nih.gov/pubmed/12482849 PubMed 1409590 http://www.ncbi.nlm.nih.gov/pubmed/1409590 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19171121 http://www.ncbi.nlm.nih.gov/pubmed/19171121 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417171 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417171 RefSeq WP_001295176 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295176 STRING 511145.b2686 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2686&targetmode=cogs STRING COG0477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0477&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.3 http://www.tcdb.org/search/result.php?tc=2.A.1.3 TIGRFAMs TIGR00711 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00711 UniProtKB EMRB_ECOLI http://www.uniprot.org/uniprot/EMRB_ECOLI UniProtKB-AC P0AEJ0 http://www.uniprot.org/uniprot/P0AEJ0 charge swissprot:EMRB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EMRB_ECOLI eggNOG ENOG4105C0R http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C0R eggNOG ENOG410XNN3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNN3 epestfind swissprot:EMRB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EMRB_ECOLI garnier swissprot:EMRB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EMRB_ECOLI helixturnhelix swissprot:EMRB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EMRB_ECOLI hmoment swissprot:EMRB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EMRB_ECOLI iep swissprot:EMRB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EMRB_ECOLI inforesidue swissprot:EMRB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EMRB_ECOLI octanol swissprot:EMRB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EMRB_ECOLI pepcoil swissprot:EMRB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EMRB_ECOLI pepdigest swissprot:EMRB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EMRB_ECOLI pepinfo swissprot:EMRB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EMRB_ECOLI pepnet swissprot:EMRB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EMRB_ECOLI pepstats swissprot:EMRB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EMRB_ECOLI pepwheel swissprot:EMRB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EMRB_ECOLI pepwindow swissprot:EMRB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EMRB_ECOLI sigcleave swissprot:EMRB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EMRB_ECOLI ## Database ID URL or Descriptions # CDD cd14804 Tra_M # DISRUPTION PHENOTYPE Loss of conjugative DNA transfer. {ECO:0000269|PubMed 8736534}. # FUNCTION TRAM1_ECOLI Conjugative DNA transfer (CDT) is the unidirectional transfer of ssDNA plasmid from a donor to a recipient cell. It is the central mechanism by which antibiotic resistance and virulence factors are propagated in bacterial populations. Part of the relaxosome, which facilitates a site- and strand-specific cut in the origin of transfer by TraI, at the nic site. Cooperatively binds 3 regions in the F plasmid oriT locus; 2 are required for autoregulation while the other is required for plasmid transfer. Bends oriT DNA less than 50 degrees. Plasmid specificity is conferred by the TraD-TraM pair. {ECO 0000269|PubMed 11875064, ECO 0000269|PubMed 1479887, ECO 0000269|PubMed 17238924, ECO 0000269|PubMed 8736534}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0000746 conjugation; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # INDUCTION Regulates its own expression from two promoters, requires TraY as well as expression of the tra operon for maximal transcription. TraM is in a monocistonic operon. {ECO:0000269|PubMed 8736534}. # InterPro IPR007925 TRelaxosome_TraM # InterPro IPR010992 IHF-like_DNA-bd_dom # Organism TRAM1_ECOLI Escherichia coli (strain K12) # PDB 2G7O X-ray; 1.40 A; A=58-127 # PDB 2G9E X-ray; 1.80 A; A=58-127 # PDB 3D8A X-ray; 2.55 A; A/B/C/D/E/F/G/H=58-127 # PDB 4QPO X-ray; 2.00 A; A/B/C/D=2-54 # PDB 4QPQ X-ray; 3.11 A; A/B/C/D/E/F/G/H=2-54 # PIR A29331 JCECMF # Pfam PF05261 Tra_M # ProDom PD008204 T4SS_TraM # RecName TRAM1_ECOLI Relaxosome protein TraM # RefSeq NP_061450 NC_002483.1 # RefSeq WP_001151527 NZ_CP014273.1 # SIMILARITY Belongs to the relaxosome TraM family. {ECO 0000305}. # SUBCELLULAR LOCATION TRAM1_ECOLI Cytoplasm {ECO 0000269|PubMed 1479887}. # SUBUNIT TRAM1_ECOLI Homotetramer. 2 homotetramers cooperatively bind to DNA although they do not contact each other; cooperativity is achieved by DNA kinking and unwinding (Probable). Part of the relaxosome, a complex composed of plasmid encoded TraI, TraM, TraY and host- encoded IHF which binds to the F plasmid origin of transfer (oriT) in a site- and sequence-specific manner. Interacts with TraD. Also interacts with TraY. {ECO 0000269|PubMed 15995191, ECO 0000269|PubMed 16710295, ECO 0000269|PubMed 17238924, ECO 0000269|PubMed 18717787, ECO 0000269|PubMed 21565799, ECO 0000269|PubMed 9324263, ECO 0000305}. # SUPFAM SSF47729 SSF47729 BLAST swissprot:TRAM1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRAM1_ECOLI DIP DIP-27653N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-27653N DOI 10.1007/BF00330058 http://dx.doi.org/10.1007/BF00330058 DOI 10.1038/sj.emboj.7601151 http://dx.doi.org/10.1038/sj.emboj.7601151 DOI 10.1046/j.1365-2958.1996.5361059.x http://dx.doi.org/10.1046/j.1365-2958.1996.5361059.x DOI 10.1074/jbc.M111682200 http://dx.doi.org/10.1074/jbc.M111682200 DOI 10.1093/nar/gkr296 http://dx.doi.org/10.1093/nar/gkr296 DOI 10.1111/j.1365-2958.1992.tb01754.x http://dx.doi.org/10.1111/j.1365-2958.1992.tb01754.x DOI 10.1111/j.1365-2958.2006.05576.x http://dx.doi.org/10.1111/j.1365-2958.2006.05576.x DOI 10.1111/j.1365-2958.2008.06391.x http://dx.doi.org/10.1111/j.1365-2958.2008.06391.x DOI 10.1128/JB.187.14.4767-4773.2005 http://dx.doi.org/10.1128/JB.187.14.4767-4773.2005 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL K01147 http://www.ebi.ac.uk/ena/data/view/K01147 EMBL U01159 http://www.ebi.ac.uk/ena/data/view/U01159 EMBL X00545 http://www.ebi.ac.uk/ena/data/view/X00545 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0000746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000746 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 1263565 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263565 InterPro IPR007925 http://www.ebi.ac.uk/interpro/entry/IPR007925 InterPro IPR010992 http://www.ebi.ac.uk/interpro/entry/IPR010992 OMA SVEMERF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SVEMERF PDB 2G7O http://www.ebi.ac.uk/pdbe-srv/view/entry/2G7O PDB 2G9E http://www.ebi.ac.uk/pdbe-srv/view/entry/2G9E PDB 3D8A http://www.ebi.ac.uk/pdbe-srv/view/entry/3D8A PDB 4QPO http://www.ebi.ac.uk/pdbe-srv/view/entry/4QPO PDB 4QPQ http://www.ebi.ac.uk/pdbe-srv/view/entry/4QPQ PDBsum 2G7O http://www.ebi.ac.uk/pdbsum/2G7O PDBsum 2G9E http://www.ebi.ac.uk/pdbsum/2G9E PDBsum 3D8A http://www.ebi.ac.uk/pdbsum/3D8A PDBsum 4QPO http://www.ebi.ac.uk/pdbsum/4QPO PDBsum 4QPQ http://www.ebi.ac.uk/pdbsum/4QPQ PSORT swissprot:TRAM1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRAM1_ECOLI PSORT-B swissprot:TRAM1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRAM1_ECOLI PSORT2 swissprot:TRAM1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRAM1_ECOLI Pfam PF05261 http://pfam.xfam.org/family/PF05261 Phobius swissprot:TRAM1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRAM1_ECOLI ProteinModelPortal P10026 http://www.proteinmodelportal.org/query/uniprot/P10026 PubMed 11875064 http://www.ncbi.nlm.nih.gov/pubmed/11875064 PubMed 1479887 http://www.ncbi.nlm.nih.gov/pubmed/1479887 PubMed 15995191 http://www.ncbi.nlm.nih.gov/pubmed/15995191 PubMed 16710295 http://www.ncbi.nlm.nih.gov/pubmed/16710295 PubMed 17238924 http://www.ncbi.nlm.nih.gov/pubmed/17238924 PubMed 18717787 http://www.ncbi.nlm.nih.gov/pubmed/18717787 PubMed 21565799 http://www.ncbi.nlm.nih.gov/pubmed/21565799 PubMed 6298579 http://www.ncbi.nlm.nih.gov/pubmed/6298579 PubMed 7915817 http://www.ncbi.nlm.nih.gov/pubmed/7915817 PubMed 8736534 http://www.ncbi.nlm.nih.gov/pubmed/8736534 PubMed 9324263 http://www.ncbi.nlm.nih.gov/pubmed/9324263 RefSeq NP_061450 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061450 RefSeq WP_001151527 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001151527 SMR P10026 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P10026 SUPFAM SSF47729 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47729 UniProtKB TRAM1_ECOLI http://www.uniprot.org/uniprot/TRAM1_ECOLI UniProtKB-AC P10026 http://www.uniprot.org/uniprot/P10026 charge swissprot:TRAM1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRAM1_ECOLI epestfind swissprot:TRAM1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRAM1_ECOLI garnier swissprot:TRAM1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRAM1_ECOLI helixturnhelix swissprot:TRAM1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRAM1_ECOLI hmoment swissprot:TRAM1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRAM1_ECOLI iep swissprot:TRAM1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRAM1_ECOLI inforesidue swissprot:TRAM1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRAM1_ECOLI octanol swissprot:TRAM1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRAM1_ECOLI pepcoil swissprot:TRAM1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRAM1_ECOLI pepdigest swissprot:TRAM1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRAM1_ECOLI pepinfo swissprot:TRAM1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRAM1_ECOLI pepnet swissprot:TRAM1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRAM1_ECOLI pepstats swissprot:TRAM1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRAM1_ECOLI pepwheel swissprot:TRAM1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRAM1_ECOLI pepwindow swissprot:TRAM1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRAM1_ECOLI sigcleave swissprot:TRAM1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRAM1_ECOLI ## Database ID URL or Descriptions # BioGrid 4260358 17 # EcoGene EG14027 yebY # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # InterPro IPR019648 DUF2511 # Organism YEBY_ECOLI Escherichia coli (strain K12) # PATRIC 32118999 VBIEscCol129921_1917 # PIR G64945 G64945 # Pfam PF10709 DUF2511 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEBY_ECOLI Uncharacterized protein YebY # RefSeq NP_416353 NC_000913.3 # eggNOG ENOG4105NKT Bacteria # eggNOG ENOG4111P5F LUCA BLAST swissprot:YEBY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEBY_ECOLI BioCyc ECOL316407:JW1828-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1828-MONOMER BioCyc EcoCyc:G7012-MONOMER http://biocyc.org/getid?id=EcoCyc:G7012-MONOMER DIP DIP-48174N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48174N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3781 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3781 EcoGene EG14027 http://www.ecogene.org/geneInfo.php?eg_id=EG14027 EnsemblBacteria AAC74909 http://www.ensemblgenomes.org/id/AAC74909 EnsemblBacteria AAC74909 http://www.ensemblgenomes.org/id/AAC74909 EnsemblBacteria BAE76543 http://www.ensemblgenomes.org/id/BAE76543 EnsemblBacteria BAE76543 http://www.ensemblgenomes.org/id/BAE76543 EnsemblBacteria BAE76543 http://www.ensemblgenomes.org/id/BAE76543 EnsemblBacteria b1839 http://www.ensemblgenomes.org/id/b1839 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GeneID 947014 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947014 HOGENOM HOG000121207 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000121207&db=HOGENOM6 InterPro IPR019648 http://www.ebi.ac.uk/interpro/entry/IPR019648 KEGG_Gene ecj:JW1828 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1828 KEGG_Gene eco:b1839 http://www.genome.jp/dbget-bin/www_bget?eco:b1839 OMA STLMQYP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=STLMQYP PSORT swissprot:YEBY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEBY_ECOLI PSORT-B swissprot:YEBY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEBY_ECOLI PSORT2 swissprot:YEBY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEBY_ECOLI Pfam PF10709 http://pfam.xfam.org/family/PF10709 Phobius swissprot:YEBY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEBY_ECOLI ProteinModelPortal P64506 http://www.proteinmodelportal.org/query/uniprot/P64506 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416353 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416353 SMR P64506 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P64506 STRING 511145.b1839 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1839&targetmode=cogs UniProtKB YEBY_ECOLI http://www.uniprot.org/uniprot/YEBY_ECOLI UniProtKB-AC P64506 http://www.uniprot.org/uniprot/P64506 charge swissprot:YEBY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEBY_ECOLI eggNOG ENOG4105NKT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105NKT eggNOG ENOG4111P5F http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111P5F epestfind swissprot:YEBY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEBY_ECOLI garnier swissprot:YEBY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEBY_ECOLI helixturnhelix swissprot:YEBY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEBY_ECOLI hmoment swissprot:YEBY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEBY_ECOLI iep swissprot:YEBY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEBY_ECOLI inforesidue swissprot:YEBY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEBY_ECOLI octanol swissprot:YEBY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEBY_ECOLI pepcoil swissprot:YEBY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEBY_ECOLI pepdigest swissprot:YEBY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEBY_ECOLI pepinfo swissprot:YEBY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEBY_ECOLI pepnet swissprot:YEBY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEBY_ECOLI pepstats swissprot:YEBY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEBY_ECOLI pepwheel swissprot:YEBY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEBY_ECOLI pepwindow swissprot:YEBY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEBY_ECOLI sigcleave swissprot:YEBY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEBY_ECOLI ## Database ID URL or Descriptions # AltName SERB_ECOLI O-phosphoserine phosphohydrolase # BIOPHYSICOCHEMICAL PROPERTIES SERB_ECOLI Kinetic parameters KM=0.097 mM for P-Ser (with magnesium ions as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; KM=0.07 mM for imido-diphosphate (with magnesium ions as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; KM=6.2 mM for acetyl-phosphate (with magnesium ions as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; pH dependence Optimum pH is between 6 and 7.5. {ECO 0000269|PubMed 16990279}; # BioGrid 4262789 113 # CATALYTIC ACTIVITY SERB_ECOLI O-phospho-L(or D)-serine + H(2)O = L(or D)- serine + phosphate. # COFACTOR SERB_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 16990279}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 16990279}; Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000269|PubMed 16990279}; Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 16990279}; Note=Binds 1 Mg(2+) ion per subunit. Can also use other divalent metal cations as Mn(2+), Co(2+) and Zn(2+). {ECO 0000269|PubMed 16990279}; # EcoGene EG10945 serB # FUNCTION SERB_ECOLI Catalyzes the dephosphorylation of phosphoserine (P- Ser). Also catalyzes the hydrolysis of phosphothreonine (P-Thr). {ECO 0000269|PubMed 16990279}. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_function GO:0000287 magnesium ion binding; IDA:EcoliWiki. # GO_function GO:0004647 phosphoserine phosphatase activity; IDA:EcoliWiki. # GO_function GO:0016791 phosphatase activity; IDA:EcoliWiki. # GO_process GO:0006564 L-serine biosynthetic process; IDA:EcoliWiki. # GO_process GO:0008652 cellular amino acid biosynthetic process; IDA:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 1.10.150.210 -; 1. # Gene3D 3.40.50.1000 -; 1. # IntAct P0AGB0 3 # InterPro IPR006383 HAD-SF_hydro_IB_PSP-like # InterPro IPR023190 Pser_Pase_dom_2 # InterPro IPR023214 HAD-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00260 Glycine, serine and threonine metabolism # KEGG_Pathway ko00680 Methane metabolism # Organism SERB_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate step 3/3. # PATRIC 32124392 VBIEscCol129921_4536 # PIR A24271 PAECS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SERB_ECOLI Phosphoserine phosphatase # RefSeq NP_418805 NC_000913.3 # RefSeq WP_001132955 NZ_LN832404.1 # SIMILARITY Belongs to the HAD-like hydrolase superfamily. SerB family. {ECO 0000305}. # SUPFAM SSF56784 SSF56784 # TIGRFAMs TIGR01488 HAD-SF-IB # UniPathway UPA00135 UER00198 # eggNOG COG0560 LUCA # eggNOG ENOG4105EAC Bacteria BLAST swissprot:SERB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SERB_ECOLI BioCyc ECOL316407:JW4351-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4351-MONOMER BioCyc EcoCyc:PSERPHOSPHA-MONOMER http://biocyc.org/getid?id=EcoCyc:PSERPHOSPHA-MONOMER BioCyc MetaCyc:PSERPHOSPHA-MONOMER http://biocyc.org/getid?id=MetaCyc:PSERPHOSPHA-MONOMER COG COG0560 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0560 DIP DIP-48100N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48100N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M605449200 http://dx.doi.org/10.1074/jbc.M605449200 DOI 10.1093/nar/13.19.7025 http://dx.doi.org/10.1093/nar/13.19.7025 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.3.3 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X03046 http://www.ebi.ac.uk/ena/data/view/X03046 ENZYME 3.1.3.3 http://enzyme.expasy.org/EC/3.1.3.3 EchoBASE EB0938 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0938 EcoGene EG10945 http://www.ecogene.org/geneInfo.php?eg_id=EG10945 EnsemblBacteria AAC77341 http://www.ensemblgenomes.org/id/AAC77341 EnsemblBacteria AAC77341 http://www.ensemblgenomes.org/id/AAC77341 EnsemblBacteria BAE78377 http://www.ensemblgenomes.org/id/BAE78377 EnsemblBacteria BAE78377 http://www.ensemblgenomes.org/id/BAE78377 EnsemblBacteria BAE78377 http://www.ensemblgenomes.org/id/BAE78377 EnsemblBacteria b4388 http://www.ensemblgenomes.org/id/b4388 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0004647 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004647 GO_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GO_process GO:0006564 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006564 GO_process GO:0008652 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008652 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 1.10.150.210 http://www.cathdb.info/version/latest/superfamily/1.10.150.210 Gene3D 3.40.50.1000 http://www.cathdb.info/version/latest/superfamily/3.40.50.1000 GeneID 948913 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948913 HOGENOM HOG000231115 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231115&db=HOGENOM6 InParanoid P0AGB0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGB0 IntAct P0AGB0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AGB0* IntEnz 3.1.3.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.3 InterPro IPR006383 http://www.ebi.ac.uk/interpro/entry/IPR006383 InterPro IPR023190 http://www.ebi.ac.uk/interpro/entry/IPR023190 InterPro IPR023214 http://www.ebi.ac.uk/interpro/entry/IPR023214 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4351 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4351 KEGG_Gene eco:b4388 http://www.genome.jp/dbget-bin/www_bget?eco:b4388 KEGG_Orthology KO:K01079 http://www.genome.jp/dbget-bin/www_bget?KO:K01079 KEGG_Pathway ko00260 http://www.genome.jp/kegg-bin/show_pathway?ko00260 KEGG_Pathway ko00680 http://www.genome.jp/kegg-bin/show_pathway?ko00680 KEGG_Reaction rn:R00582 http://www.genome.jp/dbget-bin/www_bget?rn:R00582 OMA AQYKANT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AQYKANT PSORT swissprot:SERB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SERB_ECOLI PSORT-B swissprot:SERB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SERB_ECOLI PSORT2 swissprot:SERB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SERB_ECOLI Phobius swissprot:SERB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SERB_ECOLI PhylomeDB P0AGB0 http://phylomedb.org/?seqid=P0AGB0 ProteinModelPortal P0AGB0 http://www.proteinmodelportal.org/query/uniprot/P0AGB0 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16990279 http://www.ncbi.nlm.nih.gov/pubmed/16990279 PubMed 2997734 http://www.ncbi.nlm.nih.gov/pubmed/2997734 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418805 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418805 RefSeq WP_001132955 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001132955 SMR P0AGB0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AGB0 STRING 511145.b4388 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4388&targetmode=cogs STRING COG0560 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0560&targetmode=cogs SUPFAM SSF56784 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784 TIGRFAMs TIGR01488 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01488 UniProtKB SERB_ECOLI http://www.uniprot.org/uniprot/SERB_ECOLI UniProtKB-AC P0AGB0 http://www.uniprot.org/uniprot/P0AGB0 charge swissprot:SERB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SERB_ECOLI eggNOG COG0560 http://eggnogapi.embl.de/nog_data/html/tree/COG0560 eggNOG ENOG4105EAC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EAC epestfind swissprot:SERB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SERB_ECOLI garnier swissprot:SERB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SERB_ECOLI helixturnhelix swissprot:SERB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SERB_ECOLI hmoment swissprot:SERB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SERB_ECOLI iep swissprot:SERB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SERB_ECOLI inforesidue swissprot:SERB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SERB_ECOLI octanol swissprot:SERB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SERB_ECOLI pepcoil swissprot:SERB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SERB_ECOLI pepdigest swissprot:SERB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SERB_ECOLI pepinfo swissprot:SERB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SERB_ECOLI pepnet swissprot:SERB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SERB_ECOLI pepstats swissprot:SERB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SERB_ECOLI pepwheel swissprot:SERB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SERB_ECOLI pepwindow swissprot:SERB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SERB_ECOLI sigcleave swissprot:SERB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SERB_ECOLI ## Database ID URL or Descriptions # AltName GSTA_ECOLI GST B1-1 # BIOPHYSICOCHEMICAL PROPERTIES GSTA_ECOLI Kinetic parameters KM=0.041 mM for glutathione {ECO 0000269|PubMed 18778244, ECO 0000269|PubMed 2185038, ECO 0000269|PubMed 7798255}; KM=0.3 mM for glutathione {ECO 0000269|PubMed 18778244, ECO 0000269|PubMed 2185038, ECO 0000269|PubMed 7798255}; KM=0.99 mM for 1-chloro-2,4-dinitrobenzene {ECO 0000269|PubMed 18778244, ECO 0000269|PubMed 2185038, ECO 0000269|PubMed 7798255}; KM=1.9 mM for 1-chloro-2,4-dinitrobenzene {ECO 0000269|PubMed 18778244, ECO 0000269|PubMed 2185038, ECO 0000269|PubMed 7798255}; Note=kcat is 9 sec(-1) for the GSH transferase reaction with CDNB as substrate. {ECO 0000269|PubMed 18778244}; pH dependence Optimum pH is 7.5. {ECO 0000269|PubMed 2185038, ECO 0000269|PubMed 7798255}; Temperature dependence Optimum temperature is 35 degrees Celsius. {ECO 0000269|PubMed 2185038, ECO 0000269|PubMed 7798255}; # BRENDA 2.5.1.18 2026 # BioGrid 4260258 21 # CATALYTIC ACTIVITY GSTA_ECOLI RX + glutathione = HX + R-S-glutathione. {ECO 0000269|PubMed 18778244, ECO 0000269|PubMed 2185038, ECO 0000269|PubMed 7798255}. # DISRUPTION PHENOTYPE Deletion of the gstA gene decreases the resistance of the bacteria to hydrogen peroxide. {ECO:0000269|PubMed 17018556}. # EcoGene EG12613 gstA # FUNCTION GSTA_ECOLI Catalyzes the conjugation of reduced glutathione (GSH) to a wide number of exogenous and endogenous hydrophobic electrophiles. Shows activity toward 1-chloro-2,4-dinitrobenzene (CDNB) and ethacrynic acid. Also possesses thiol disulfide oxidoreductase activity, using GSH to reduce bis-(2-hydroxyethyl) disulfide (HEDS). Has a low level of glutathione-dependent peroxidase activity toward cumene hydroperoxide. Is important for defense against oxidative stress, probably via its peroxidase activity. {ECO 0000269|PubMed 17018556, ECO 0000269|PubMed 18778244, ECO 0000269|PubMed 2185038, ECO 0000269|PubMed 7798255}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0004364 glutathione transferase activity; IDA:EcoCyc. # GO_process GO:0006749 glutathione metabolic process; IBA:GO_Central. # GO_process GO:0042542 response to hydrogen peroxide; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.20.1050.10 -; 1. # Gene3D 3.40.30.10 -; 1. # InterPro IPR004045 Glutathione_S-Trfase_N # InterPro IPR004046 GST_C # InterPro IPR010987 Glutathione-S-Trfase_C-like # InterPro IPR012336 Thioredoxin-like_fold # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00480 Glutathione metabolism # KEGG_Pathway ko00980 Metabolism of xenobiotics by cytochrome P450 # KEGG_Pathway ko00982 Drug metabolism - cytochrome P450 # KEGG_Pathway ko05204 Chemical carcinogenesis # Organism GSTA_ECOLI Escherichia coli (strain K12) # PATRIC 32118572 VBIEscCol129921_1706 # PDB 1A0F X-ray; 2.10 A; A/B=1-201 # PDB 1N2A X-ray; 1.90 A; A/B=1-201 # PIR A55495 A55495 # PROSITE PS50404 GST_NTER # PROSITE PS50405 GST_CTER # Pfam PF00043 GST_C # Pfam PF13409 GST_N_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GSTA_ECOLI Glutathione S-transferase GstA # RefSeq NP_416152 NC_000913.3 # RefSeq WP_000765749 NZ_LN832404.1 # SIMILARITY Belongs to the GST superfamily. Beta family. {ECO 0000305}. # SIMILARITY Contains 1 GST C-terminal domain. {ECO 0000305}. # SIMILARITY Contains 1 GST N-terminal domain. {ECO 0000305}. # SUBCELLULAR LOCATION GSTA_ECOLI Cytoplasm. # SUBUNIT GSTA_ECOLI Homodimer. {ECO 0000269|PubMed 14635120, ECO 0000269|PubMed 2185038, ECO 0000269|PubMed 7798255, ECO 0000269|PubMed 9680481}. # SUPFAM SSF47616 SSF47616 # SUPFAM SSF52833 SSF52833 # eggNOG COG0625 LUCA # eggNOG ENOG4108K3A Bacteria BLAST swissprot:GSTA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GSTA_ECOLI BioCyc ECOL316407:JW1627-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1627-MONOMER BioCyc EcoCyc:GST-MONOMER http://biocyc.org/getid?id=EcoCyc:GST-MONOMER BioCyc MetaCyc:GST-MONOMER http://biocyc.org/getid?id=MetaCyc:GST-MONOMER COG COG0625 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0625 DIP DIP-9851N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9851N DOI 10.1002/prot.10452 http://dx.doi.org/10.1002/prot.10452 DOI 10.1006/jmbi.1998.1927 http://dx.doi.org/10.1006/jmbi.1998.1927 DOI 10.1016/0014-5793(90)80709-R http://dx.doi.org/10.1016/0014-5793(90)80709-R DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/BJ20071702 http://dx.doi.org/10.1042/BJ20071702 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/jb/mvj199 http://dx.doi.org/10.1093/jb/mvj199 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.5.1.18 {ECO:0000269|PubMed:7798255} http://www.genome.jp/dbget-bin/www_bget?EC:2.5.1.18 {ECO:0000269|PubMed:7798255} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D38497 http://www.ebi.ac.uk/ena/data/view/D38497 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.5.1.18 {ECO:0000269|PubMed:7798255} http://enzyme.expasy.org/EC/2.5.1.18 {ECO:0000269|PubMed:7798255} EchoBASE EB2497 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2497 EcoGene EG12613 http://www.ecogene.org/geneInfo.php?eg_id=EG12613 EnsemblBacteria AAC74707 http://www.ensemblgenomes.org/id/AAC74707 EnsemblBacteria AAC74707 http://www.ensemblgenomes.org/id/AAC74707 EnsemblBacteria BAA15396 http://www.ensemblgenomes.org/id/BAA15396 EnsemblBacteria BAA15396 http://www.ensemblgenomes.org/id/BAA15396 EnsemblBacteria BAA15396 http://www.ensemblgenomes.org/id/BAA15396 EnsemblBacteria b1635 http://www.ensemblgenomes.org/id/b1635 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004364 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004364 GO_process GO:0006749 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006749 GO_process GO:0042542 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042542 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016765 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.20.1050.10 http://www.cathdb.info/version/latest/superfamily/1.20.1050.10 Gene3D 3.40.30.10 http://www.cathdb.info/version/latest/superfamily/3.40.30.10 GeneID 945758 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945758 HOGENOM HOG000125748 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125748&db=HOGENOM6 InParanoid P0A9D2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9D2 IntAct P0A9D2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9D2* IntEnz 2.5.1.18 {ECO:0000269|PubMed:7798255} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.5.1.18 {ECO:0000269|PubMed:7798255} InterPro IPR004045 http://www.ebi.ac.uk/interpro/entry/IPR004045 InterPro IPR004046 http://www.ebi.ac.uk/interpro/entry/IPR004046 InterPro IPR010987 http://www.ebi.ac.uk/interpro/entry/IPR010987 InterPro IPR012336 http://www.ebi.ac.uk/interpro/entry/IPR012336 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1627 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1627 KEGG_Gene eco:b1635 http://www.genome.jp/dbget-bin/www_bget?eco:b1635 KEGG_Orthology KO:K00799 http://www.genome.jp/dbget-bin/www_bget?KO:K00799 KEGG_Pathway ko00480 http://www.genome.jp/kegg-bin/show_pathway?ko00480 KEGG_Pathway ko00980 http://www.genome.jp/kegg-bin/show_pathway?ko00980 KEGG_Pathway ko00982 http://www.genome.jp/kegg-bin/show_pathway?ko00982 KEGG_Pathway ko05204 http://www.genome.jp/kegg-bin/show_pathway?ko05204 KEGG_Reaction rn:R03522 http://www.genome.jp/dbget-bin/www_bget?rn:R03522 KEGG_Reaction rn:R07002 http://www.genome.jp/dbget-bin/www_bget?rn:R07002 KEGG_Reaction rn:R07003 http://www.genome.jp/dbget-bin/www_bget?rn:R07003 KEGG_Reaction rn:R07004 http://www.genome.jp/dbget-bin/www_bget?rn:R07004 KEGG_Reaction rn:R07023 http://www.genome.jp/dbget-bin/www_bget?rn:R07023 KEGG_Reaction rn:R07024 http://www.genome.jp/dbget-bin/www_bget?rn:R07024 KEGG_Reaction rn:R07025 http://www.genome.jp/dbget-bin/www_bget?rn:R07025 KEGG_Reaction rn:R07026 http://www.genome.jp/dbget-bin/www_bget?rn:R07026 KEGG_Reaction rn:R07069 http://www.genome.jp/dbget-bin/www_bget?rn:R07069 KEGG_Reaction rn:R07070 http://www.genome.jp/dbget-bin/www_bget?rn:R07070 KEGG_Reaction rn:R07083 http://www.genome.jp/dbget-bin/www_bget?rn:R07083 KEGG_Reaction rn:R07084 http://www.genome.jp/dbget-bin/www_bget?rn:R07084 KEGG_Reaction rn:R07091 http://www.genome.jp/dbget-bin/www_bget?rn:R07091 KEGG_Reaction rn:R07092 http://www.genome.jp/dbget-bin/www_bget?rn:R07092 KEGG_Reaction rn:R07093 http://www.genome.jp/dbget-bin/www_bget?rn:R07093 KEGG_Reaction rn:R07094 http://www.genome.jp/dbget-bin/www_bget?rn:R07094 KEGG_Reaction rn:R07100 http://www.genome.jp/dbget-bin/www_bget?rn:R07100 KEGG_Reaction rn:R07113 http://www.genome.jp/dbget-bin/www_bget?rn:R07113 KEGG_Reaction rn:R07116 http://www.genome.jp/dbget-bin/www_bget?rn:R07116 KEGG_Reaction rn:R08280 http://www.genome.jp/dbget-bin/www_bget?rn:R08280 KEGG_Reaction rn:R09409 http://www.genome.jp/dbget-bin/www_bget?rn:R09409 OMA SHKLQDG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SHKLQDG PDB 1A0F http://www.ebi.ac.uk/pdbe-srv/view/entry/1A0F PDB 1N2A http://www.ebi.ac.uk/pdbe-srv/view/entry/1N2A PDBsum 1A0F http://www.ebi.ac.uk/pdbsum/1A0F PDBsum 1N2A http://www.ebi.ac.uk/pdbsum/1N2A PROSITE PS50404 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50404 PROSITE PS50405 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50405 PSORT swissprot:GSTA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GSTA_ECOLI PSORT-B swissprot:GSTA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GSTA_ECOLI PSORT2 swissprot:GSTA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GSTA_ECOLI Pfam PF00043 http://pfam.xfam.org/family/PF00043 Pfam PF13409 http://pfam.xfam.org/family/PF13409 Phobius swissprot:GSTA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GSTA_ECOLI PhylomeDB P0A9D2 http://phylomedb.org/?seqid=P0A9D2 ProteinModelPortal P0A9D2 http://www.proteinmodelportal.org/query/uniprot/P0A9D2 PubMed 14635120 http://www.ncbi.nlm.nih.gov/pubmed/14635120 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17018556 http://www.ncbi.nlm.nih.gov/pubmed/17018556 PubMed 18778244 http://www.ncbi.nlm.nih.gov/pubmed/18778244 PubMed 2185038 http://www.ncbi.nlm.nih.gov/pubmed/2185038 PubMed 7798255 http://www.ncbi.nlm.nih.gov/pubmed/7798255 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9680481 http://www.ncbi.nlm.nih.gov/pubmed/9680481 RefSeq NP_416152 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416152 RefSeq WP_000765749 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000765749 SMR P0A9D2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9D2 STRING 511145.b1635 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1635&targetmode=cogs STRING COG0625 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0625&targetmode=cogs SUPFAM SSF47616 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47616 SUPFAM SSF52833 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52833 SWISS-2DPAGE P0A9D2 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A9D2 UniProtKB GSTA_ECOLI http://www.uniprot.org/uniprot/GSTA_ECOLI UniProtKB-AC P0A9D2 http://www.uniprot.org/uniprot/P0A9D2 charge swissprot:GSTA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GSTA_ECOLI eggNOG COG0625 http://eggnogapi.embl.de/nog_data/html/tree/COG0625 eggNOG ENOG4108K3A http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108K3A epestfind swissprot:GSTA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GSTA_ECOLI garnier swissprot:GSTA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GSTA_ECOLI helixturnhelix swissprot:GSTA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GSTA_ECOLI hmoment swissprot:GSTA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GSTA_ECOLI iep swissprot:GSTA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GSTA_ECOLI inforesidue swissprot:GSTA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GSTA_ECOLI octanol swissprot:GSTA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GSTA_ECOLI pepcoil swissprot:GSTA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GSTA_ECOLI pepdigest swissprot:GSTA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GSTA_ECOLI pepinfo swissprot:GSTA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GSTA_ECOLI pepnet swissprot:GSTA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GSTA_ECOLI pepstats swissprot:GSTA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GSTA_ECOLI pepwheel swissprot:GSTA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GSTA_ECOLI pepwindow swissprot:GSTA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GSTA_ECOLI sigcleave swissprot:GSTA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GSTA_ECOLI ## Database ID URL or Descriptions # AltName AMTB_ECOLI Ammonia transporter # BioGrid 4259856 9 # EcoGene EG11821 amtB # FUNCTION AMTB_ECOLI Involved in the uptake of ammonia. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_function GO:0008519 ammonium transmembrane transporter activity; IDA:UniProtKB. # GO_function GO:0015292 uniporter activity; IMP:EcoCyc. # GO_process GO:0015670 carbon dioxide transport; IDA:UniProtKB. # GO_process GO:0015695 organic cation transport; IBA:GO_Central. # GO_process GO:0015696 ammonium transport; IDA:UniProtKB. # GO_process GO:0019740 nitrogen utilization; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # Gene3D 1.10.3430.10 -; 1. # IntAct P69681 3 # InterPro IPR001905 Ammonium_transpt # InterPro IPR018047 Ammonium_transpt_CS # InterPro IPR024041 NH4_transpt_AmtB-like_dom # InterPro IPR029020 Ammonium/urea_transptr # KEGG_Brite ko02000 Transporters # Organism AMTB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11730 PTHR11730 # PATRIC 32116057 VBIEscCol129921_0470 # PDB 1U77 X-ray; 2.00 A; A=23-407 # PDB 1U7C X-ray; 1.85 A; A=23-407 # PDB 1U7G X-ray; 1.40 A; A=23-407 # PDB 1XQE X-ray; 2.10 A; A=23-428 # PDB 1XQF X-ray; 1.80 A; A=23-428 # PDB 2NMR X-ray; 2.10 A; A=23-428 # PDB 2NOP X-ray; 2.00 A; A=23-428 # PDB 2NOW X-ray; 2.20 A; A=23-428 # PDB 2NPC X-ray; 2.10 A; A=23-428 # PDB 2NPD X-ray; 2.10 A; A=23-428 # PDB 2NPE X-ray; 2.10 A; A=23-428 # PDB 2NPG X-ray; 2.00 A; A=23-428 # PDB 2NPJ X-ray; 2.00 A; A=23-428 # PDB 2NPK X-ray; 2.00 A; A=23-428 # PDB 2NS1 X-ray; 1.96 A; A=23-428 # PDB 2NUU X-ray; 2.50 A; A/B/C/D/E/F=25-428 # PDB 3C1G X-ray; 2.30 A; A=23-428 # PDB 3C1H X-ray; 2.20 A; A=23-428 # PDB 3C1I X-ray; 2.30 A; A=23-428 # PDB 3C1J X-ray; 2.00 A; A=23-428 # PIR A90692 A90692 # PIR C64775 C64775 # PIR E85542 E85542 # PROSITE PS01219 AMMONIUM_TRANSP # Pfam PF00909 Ammonium_transp # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AMTB_ECOLI Ammonia channel # RefSeq NP_414985 NC_000913.3 # RefSeq WP_000685029 NZ_LN832404.1 # SIMILARITY Belongs to the ammonia transporter channel (TC 1.A.11.2) family. {ECO 0000305}. # SUBCELLULAR LOCATION AMTB_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT Homotrimer. May interact with GlnK. {ECO:0000269|PubMed 12023896}. # SUPFAM SSF111352 SSF111352 # TCDB 1.A.11.1 the ammonium transporter channel (amt) family # TIGRFAMs TIGR00836 amt # eggNOG ENOG4105BZU Bacteria # eggNOG ENOG410XNMH LUCA BLAST swissprot:AMTB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AMTB_ECOLI BioCyc ECOL316407:JW0441-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0441-MONOMER BioCyc EcoCyc:AMTB-MONOMER http://biocyc.org/getid?id=EcoCyc:AMTB-MONOMER BioCyc MetaCyc:AMTB-MONOMER http://biocyc.org/getid?id=MetaCyc:AMTB-MONOMER COG COG0004 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0004 DIP DIP-29874N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-29874N DOI 10.1016/S0168-9525(99)01887-9 http://dx.doi.org/10.1016/S0168-9525(99)01887-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/BJ20011761 http://dx.doi.org/10.1042/BJ20011761 DOI 10.1046/j.1365-2958.1996.6281349.x http://dx.doi.org/10.1046/j.1365-2958.1996.6281349.x DOI 10.1046/j.1365-2958.2000.01994.x http://dx.doi.org/10.1046/j.1365-2958.2000.01994.x DOI 10.1073/pnas.0406475101 http://dx.doi.org/10.1073/pnas.0406475101 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1126/science.1101952 http://dx.doi.org/10.1126/science.1101952 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M63308 http://www.ebi.ac.uk/ena/data/view/M63308 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U40429 http://www.ebi.ac.uk/ena/data/view/U40429 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EchoBASE EB1768 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1768 EcoGene EG11821 http://www.ecogene.org/geneInfo.php?eg_id=EG11821 EnsemblBacteria AAC73554 http://www.ensemblgenomes.org/id/AAC73554 EnsemblBacteria AAC73554 http://www.ensemblgenomes.org/id/AAC73554 EnsemblBacteria BAE76231 http://www.ensemblgenomes.org/id/BAE76231 EnsemblBacteria BAE76231 http://www.ensemblgenomes.org/id/BAE76231 EnsemblBacteria BAE76231 http://www.ensemblgenomes.org/id/BAE76231 EnsemblBacteria b0451 http://www.ensemblgenomes.org/id/b0451 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0008519 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008519 GO_function GO:0015292 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015292 GO_process GO:0015670 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015670 GO_process GO:0015695 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015695 GO_process GO:0015696 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015696 GO_process GO:0019740 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019740 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.10.3430.10 http://www.cathdb.info/version/latest/superfamily/1.10.3430.10 GeneID 945084 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945084 HOGENOM HOG000017736 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000017736&db=HOGENOM6 InParanoid P69681 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P69681 IntAct P69681 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69681* InterPro IPR001905 http://www.ebi.ac.uk/interpro/entry/IPR001905 InterPro IPR018047 http://www.ebi.ac.uk/interpro/entry/IPR018047 InterPro IPR024041 http://www.ebi.ac.uk/interpro/entry/IPR024041 InterPro IPR029020 http://www.ebi.ac.uk/interpro/entry/IPR029020 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0441 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0441 KEGG_Gene eco:b0451 http://www.genome.jp/dbget-bin/www_bget?eco:b0451 KEGG_Orthology KO:K03320 http://www.genome.jp/dbget-bin/www_bget?KO:K03320 OMA CVLWVVY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CVLWVVY PANTHER PTHR11730 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11730 PDB 1U77 http://www.ebi.ac.uk/pdbe-srv/view/entry/1U77 PDB 1U7C http://www.ebi.ac.uk/pdbe-srv/view/entry/1U7C PDB 1U7G http://www.ebi.ac.uk/pdbe-srv/view/entry/1U7G PDB 1XQE http://www.ebi.ac.uk/pdbe-srv/view/entry/1XQE PDB 1XQF http://www.ebi.ac.uk/pdbe-srv/view/entry/1XQF PDB 2NMR http://www.ebi.ac.uk/pdbe-srv/view/entry/2NMR PDB 2NOP http://www.ebi.ac.uk/pdbe-srv/view/entry/2NOP PDB 2NOW http://www.ebi.ac.uk/pdbe-srv/view/entry/2NOW PDB 2NPC http://www.ebi.ac.uk/pdbe-srv/view/entry/2NPC PDB 2NPD http://www.ebi.ac.uk/pdbe-srv/view/entry/2NPD PDB 2NPE http://www.ebi.ac.uk/pdbe-srv/view/entry/2NPE PDB 2NPG http://www.ebi.ac.uk/pdbe-srv/view/entry/2NPG PDB 2NPJ http://www.ebi.ac.uk/pdbe-srv/view/entry/2NPJ PDB 2NPK http://www.ebi.ac.uk/pdbe-srv/view/entry/2NPK PDB 2NS1 http://www.ebi.ac.uk/pdbe-srv/view/entry/2NS1 PDB 2NUU http://www.ebi.ac.uk/pdbe-srv/view/entry/2NUU PDB 3C1G http://www.ebi.ac.uk/pdbe-srv/view/entry/3C1G PDB 3C1H http://www.ebi.ac.uk/pdbe-srv/view/entry/3C1H PDB 3C1I http://www.ebi.ac.uk/pdbe-srv/view/entry/3C1I PDB 3C1J http://www.ebi.ac.uk/pdbe-srv/view/entry/3C1J PDBsum 1U77 http://www.ebi.ac.uk/pdbsum/1U77 PDBsum 1U7C http://www.ebi.ac.uk/pdbsum/1U7C PDBsum 1U7G http://www.ebi.ac.uk/pdbsum/1U7G PDBsum 1XQE http://www.ebi.ac.uk/pdbsum/1XQE PDBsum 1XQF http://www.ebi.ac.uk/pdbsum/1XQF PDBsum 2NMR http://www.ebi.ac.uk/pdbsum/2NMR PDBsum 2NOP http://www.ebi.ac.uk/pdbsum/2NOP PDBsum 2NOW http://www.ebi.ac.uk/pdbsum/2NOW PDBsum 2NPC http://www.ebi.ac.uk/pdbsum/2NPC PDBsum 2NPD http://www.ebi.ac.uk/pdbsum/2NPD PDBsum 2NPE http://www.ebi.ac.uk/pdbsum/2NPE PDBsum 2NPG http://www.ebi.ac.uk/pdbsum/2NPG PDBsum 2NPJ http://www.ebi.ac.uk/pdbsum/2NPJ PDBsum 2NPK http://www.ebi.ac.uk/pdbsum/2NPK PDBsum 2NS1 http://www.ebi.ac.uk/pdbsum/2NS1 PDBsum 2NUU http://www.ebi.ac.uk/pdbsum/2NUU PDBsum 3C1G http://www.ebi.ac.uk/pdbsum/3C1G PDBsum 3C1H http://www.ebi.ac.uk/pdbsum/3C1H PDBsum 3C1I http://www.ebi.ac.uk/pdbsum/3C1I PDBsum 3C1J http://www.ebi.ac.uk/pdbsum/3C1J PROSITE PS01219 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01219 PSORT swissprot:AMTB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AMTB_ECOLI PSORT-B swissprot:AMTB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AMTB_ECOLI PSORT2 swissprot:AMTB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AMTB_ECOLI Pfam PF00909 http://pfam.xfam.org/family/PF00909 Phobius swissprot:AMTB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AMTB_ECOLI PhylomeDB P69681 http://phylomedb.org/?seqid=P69681 ProteinModelPortal P69681 http://www.proteinmodelportal.org/query/uniprot/P69681 PubMed 10637624 http://www.ncbi.nlm.nih.gov/pubmed/10637624 PubMed 10931328 http://www.ncbi.nlm.nih.gov/pubmed/10931328 PubMed 12023896 http://www.ncbi.nlm.nih.gov/pubmed/12023896 PubMed 15361618 http://www.ncbi.nlm.nih.gov/pubmed/15361618 PubMed 15563598 http://www.ncbi.nlm.nih.gov/pubmed/15563598 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 1645722 http://www.ncbi.nlm.nih.gov/pubmed/1645722 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 8843440 http://www.ncbi.nlm.nih.gov/pubmed/8843440 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414985 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414985 RefSeq WP_000685029 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000685029 SMR P69681 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69681 STRING 511145.b0451 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0451&targetmode=cogs STRING COG0004 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0004&targetmode=cogs SUPFAM SSF111352 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF111352 TCDB 1.A.11.1 http://www.tcdb.org/search/result.php?tc=1.A.11.1 TIGRFAMs TIGR00836 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00836 UniProtKB AMTB_ECOLI http://www.uniprot.org/uniprot/AMTB_ECOLI UniProtKB-AC P69681 http://www.uniprot.org/uniprot/P69681 charge swissprot:AMTB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AMTB_ECOLI eggNOG ENOG4105BZU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZU eggNOG ENOG410XNMH http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNMH epestfind swissprot:AMTB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AMTB_ECOLI garnier swissprot:AMTB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AMTB_ECOLI helixturnhelix swissprot:AMTB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AMTB_ECOLI hmoment swissprot:AMTB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AMTB_ECOLI iep swissprot:AMTB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AMTB_ECOLI inforesidue swissprot:AMTB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AMTB_ECOLI octanol swissprot:AMTB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AMTB_ECOLI pepcoil swissprot:AMTB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AMTB_ECOLI pepdigest swissprot:AMTB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AMTB_ECOLI pepinfo swissprot:AMTB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AMTB_ECOLI pepnet swissprot:AMTB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AMTB_ECOLI pepstats swissprot:AMTB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AMTB_ECOLI pepwheel swissprot:AMTB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AMTB_ECOLI pepwindow swissprot:AMTB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AMTB_ECOLI sigcleave swissprot:AMTB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AMTB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260838 195 # EcoGene EG13927 mdtJ # FUNCTION MDTJ_ECOLI Catalyzes the excretion of spermidine. Can also confer resistance to deoxycholate and SDS. {ECO 0000269|PubMed 11566977, ECO 0000269|PubMed 18039771}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; ISM:EcoCyc. # GO_function GO:0015606 spermidine transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:1903711 spermidine transmembrane transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0055085 transmembrane transport # HAMAP MF_01598 MdtJ # INDUCTION Induced by spermidine. {ECO:0000269|PubMed 18039771}. # InterPro IPR000390 Small_multidrug_res # InterPro IPR023740 Spermidine_export_MdtJ # KEGG_Brite ko02000 Transporters # Organism MDTJ_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30561:SF2 PTHR30561:SF2 # PATRIC 32118502 VBIEscCol129921_1671 # PIR B64916 B64916 # Pfam PF00893 Multi_Drug_Res # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MDTJ_ECOLI Spermidine export protein MdtJ # RefSeq NP_416117 NC_000913.3 # RefSeq WP_000276149 NZ_LN832404.1 # SIMILARITY Belongs to the small multidrug resistance (SMR) protein family. MdtJ subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION MDTJ_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT Forms a complex with MdtI. {ECO:0000305|PubMed 18039771}. # eggNOG COG2076 LUCA # eggNOG ENOG41090TI Bacteria BLAST swissprot:MDTJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MDTJ_ECOLI BioCyc ECOL316407:JW1592-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1592-MONOMER BioCyc EcoCyc:B1600-MONOMER http://biocyc.org/getid?id=EcoCyc:B1600-MONOMER BioCyc MetaCyc:B1600-MONOMER http://biocyc.org/getid?id=MetaCyc:B1600-MONOMER COG COG2076 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2076 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01505-07 http://dx.doi.org/10.1128/JB.01505-07 DOI 10.1128/JB.183.20.5803-5812.2001 http://dx.doi.org/10.1128/JB.183.20.5803-5812.2001 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3686 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3686 EcoGene EG13927 http://www.ecogene.org/geneInfo.php?eg_id=EG13927 EnsemblBacteria AAC74672 http://www.ensemblgenomes.org/id/AAC74672 EnsemblBacteria AAC74672 http://www.ensemblgenomes.org/id/AAC74672 EnsemblBacteria BAA15334 http://www.ensemblgenomes.org/id/BAA15334 EnsemblBacteria BAA15334 http://www.ensemblgenomes.org/id/BAA15334 EnsemblBacteria BAA15334 http://www.ensemblgenomes.org/id/BAA15334 EnsemblBacteria b1600 http://www.ensemblgenomes.org/id/b1600 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015606 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015606 GO_process GO:1903711 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1903711 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 946139 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946139 HAMAP MF_01598 http://hamap.expasy.org/unirule/MF_01598 HOGENOM HOG000268006 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000268006&db=HOGENOM6 InParanoid P69212 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P69212 InterPro IPR000390 http://www.ebi.ac.uk/interpro/entry/IPR000390 InterPro IPR023740 http://www.ebi.ac.uk/interpro/entry/IPR023740 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1592 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1592 KEGG_Gene eco:b1600 http://www.genome.jp/dbget-bin/www_bget?eco:b1600 KEGG_Orthology KO:K11743 http://www.genome.jp/dbget-bin/www_bget?KO:K11743 OMA YALWEGV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YALWEGV PANTHER PTHR30561:SF2 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30561:SF2 PSORT swissprot:MDTJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MDTJ_ECOLI PSORT-B swissprot:MDTJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MDTJ_ECOLI PSORT2 swissprot:MDTJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MDTJ_ECOLI Pfam PF00893 http://pfam.xfam.org/family/PF00893 Phobius swissprot:MDTJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MDTJ_ECOLI PhylomeDB P69212 http://phylomedb.org/?seqid=P69212 ProteinModelPortal P69212 http://www.proteinmodelportal.org/query/uniprot/P69212 PubMed 11566977 http://www.ncbi.nlm.nih.gov/pubmed/11566977 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18039771 http://www.ncbi.nlm.nih.gov/pubmed/18039771 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416117 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416117 RefSeq WP_000276149 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000276149 STRING 511145.b1600 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1600&targetmode=cogs STRING COG2076 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2076&targetmode=cogs UniProtKB MDTJ_ECOLI http://www.uniprot.org/uniprot/MDTJ_ECOLI UniProtKB-AC P69212 http://www.uniprot.org/uniprot/P69212 charge swissprot:MDTJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MDTJ_ECOLI eggNOG COG2076 http://eggnogapi.embl.de/nog_data/html/tree/COG2076 eggNOG ENOG41090TI http://eggnogapi.embl.de/nog_data/html/tree/ENOG41090TI epestfind swissprot:MDTJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MDTJ_ECOLI garnier swissprot:MDTJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MDTJ_ECOLI helixturnhelix swissprot:MDTJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MDTJ_ECOLI hmoment swissprot:MDTJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MDTJ_ECOLI iep swissprot:MDTJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MDTJ_ECOLI inforesidue swissprot:MDTJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MDTJ_ECOLI octanol swissprot:MDTJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MDTJ_ECOLI pepcoil swissprot:MDTJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MDTJ_ECOLI pepdigest swissprot:MDTJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MDTJ_ECOLI pepinfo swissprot:MDTJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MDTJ_ECOLI pepnet swissprot:MDTJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MDTJ_ECOLI pepstats swissprot:MDTJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MDTJ_ECOLI pepwheel swissprot:MDTJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MDTJ_ECOLI pepwindow swissprot:MDTJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MDTJ_ECOLI sigcleave swissprot:MDTJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MDTJ_ECOLI ## Database ID URL or Descriptions # EcoGene EG12217 yhhQ # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR003744 DUF165 # Organism YHHQ_ECOLI Escherichia coli (strain K12) # PATRIC 32122386 VBIEscCol129921_3570 # PIR S47690 S47690 # Pfam PF02592 Vut_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHHQ_ECOLI Inner membrane protein YhhQ # RefSeq NP_417928 NC_000913.3 # RefSeq WP_001100469 NZ_LN832404.1 # SIMILARITY To H.influenzae HI_0862. {ECO 0000305}. # SUBCELLULAR LOCATION YHHQ_ECOLI Cell inner membrane; Multi-pass membrane protein. # TIGRFAMs TIGR00697 TIGR00697 # eggNOG COG1738 LUCA # eggNOG ENOG4105EX9 Bacteria BLAST swissprot:YHHQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHHQ_ECOLI BioCyc ECOL316407:JW3436-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3436-MONOMER BioCyc EcoCyc:EG12217-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12217-MONOMER COG COG1738 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1738 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2131 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2131 EcoGene EG12217 http://www.ecogene.org/geneInfo.php?eg_id=EG12217 EnsemblBacteria AAC76496 http://www.ensemblgenomes.org/id/AAC76496 EnsemblBacteria AAC76496 http://www.ensemblgenomes.org/id/AAC76496 EnsemblBacteria BAE77822 http://www.ensemblgenomes.org/id/BAE77822 EnsemblBacteria BAE77822 http://www.ensemblgenomes.org/id/BAE77822 EnsemblBacteria BAE77822 http://www.ensemblgenomes.org/id/BAE77822 EnsemblBacteria b3471 http://www.ensemblgenomes.org/id/b3471 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 947984 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947984 HOGENOM HOG000284591 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000284591&db=HOGENOM6 InParanoid P37619 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37619 InterPro IPR003744 http://www.ebi.ac.uk/interpro/entry/IPR003744 KEGG_Gene ecj:JW3436 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3436 KEGG_Gene eco:b3471 http://www.genome.jp/dbget-bin/www_bget?eco:b3471 KEGG_Orthology KO:K09125 http://www.genome.jp/dbget-bin/www_bget?KO:K09125 OMA RSTDAFM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RSTDAFM PSORT swissprot:YHHQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHHQ_ECOLI PSORT-B swissprot:YHHQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHHQ_ECOLI PSORT2 swissprot:YHHQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHHQ_ECOLI Pfam PF02592 http://pfam.xfam.org/family/PF02592 Phobius swissprot:YHHQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHHQ_ECOLI PhylomeDB P37619 http://phylomedb.org/?seqid=P37619 ProteinModelPortal P37619 http://www.proteinmodelportal.org/query/uniprot/P37619 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417928 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417928 RefSeq WP_001100469 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001100469 STRING 511145.b3471 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3471&targetmode=cogs STRING COG1738 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1738&targetmode=cogs TIGRFAMs TIGR00697 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00697 UniProtKB YHHQ_ECOLI http://www.uniprot.org/uniprot/YHHQ_ECOLI UniProtKB-AC P37619 http://www.uniprot.org/uniprot/P37619 charge swissprot:YHHQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHHQ_ECOLI eggNOG COG1738 http://eggnogapi.embl.de/nog_data/html/tree/COG1738 eggNOG ENOG4105EX9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EX9 epestfind swissprot:YHHQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHHQ_ECOLI garnier swissprot:YHHQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHHQ_ECOLI helixturnhelix swissprot:YHHQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHHQ_ECOLI hmoment swissprot:YHHQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHHQ_ECOLI iep swissprot:YHHQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHHQ_ECOLI inforesidue swissprot:YHHQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHHQ_ECOLI octanol swissprot:YHHQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHHQ_ECOLI pepcoil swissprot:YHHQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHHQ_ECOLI pepdigest swissprot:YHHQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHHQ_ECOLI pepinfo swissprot:YHHQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHHQ_ECOLI pepnet swissprot:YHHQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHHQ_ECOLI pepstats swissprot:YHHQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHHQ_ECOLI pepwheel swissprot:YHHQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHHQ_ECOLI pepwindow swissprot:YHHQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHHQ_ECOLI sigcleave swissprot:YHHQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHHQ_ECOLI ## Database ID URL or Descriptions # AltName ARNF_ECOLI Undecaprenyl phosphate-aminoarabinose flippase subunit ArnF # BioGrid 4260501 651 # DISRUPTION PHENOTYPE Cells lacking this gene are polymyxin sensitive. Lipid A is no longer modified with L-Ara4N even though the level of the lipid-linked donor of the L-Ara4N moiety, alpha- L-Ara4N-phosphoundecaprenol, is not reduced. However, the alpha-L- Ara4N-phosphoundecaprenol is less concentrated on the periplasmic surface of the inner membrane when compared to wild type. {ECO:0000269|PubMed 17928292}. # EcoGene EG14094 arnF # FUNCTION ARNF_ECOLI Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane. {ECO 0000269|PubMed 17928292}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IEA:UniProtKB-HAMAP. # GO_function GO:0022891 substrate-specific transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0006810 transport; IMP:EcoCyc. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0009245 lipid A biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0010041 response to iron(III) ion; IGI:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # HAMAP MF_00538 Flippase_ArnF # INDUCTION Induced by BasR. {ECO:0000269|PubMed 15569938}. # InterPro IPR022832 Flippase_ArnF # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # Organism ARNF_ECOLI Escherichia coli (strain K12) # PATHWAY ARNF_ECOLI Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. # PATRIC 32119883 VBIEscCol129921_2351 # PIR H64996 H64996 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ARNF_ECOLI Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF # RefSeq NP_416761 NC_000913.3 # RefSeq WP_000523880 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB04894.1; Type=Frameshift; Positions=128; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ArnF family. {ECO 0000305}. # SUBCELLULAR LOCATION ARNF_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT Heterodimer of ArnE and ArnF. {ECO:0000305|PubMed 17928292}. # TCDB 2.A.7.22 the drug/metabolite transporter (dmt) superfamily # eggNOG COG0697 LUCA # eggNOG ENOG4105U65 Bacteria BLAST swissprot:ARNF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARNF_ECOLI BioCyc ECOL316407:JW5373-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5373-MONOMER BioCyc EcoCyc:G7171-MONOMER http://biocyc.org/getid?id=EcoCyc:G7171-MONOMER BioCyc MetaCyc:G7171-MONOMER http://biocyc.org/getid?id=MetaCyc:G7171-MONOMER COG COG0697 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0697 DIP DIP-48225N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48225N DOI 10.1016/0378-1119(95)00721-0 http://dx.doi.org/10.1016/0378-1119(95)00721-0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0406038101 http://dx.doi.org/10.1073/pnas.0406038101 DOI 10.1074/jbc.M706172200 http://dx.doi.org/10.1074/jbc.M706172200 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L35031 http://www.ebi.ac.uk/ena/data/view/L35031 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3847 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3847 EcoGene EG14094 http://www.ecogene.org/geneInfo.php?eg_id=EG14094 EnsemblBacteria AAC75318 http://www.ensemblgenomes.org/id/AAC75318 EnsemblBacteria AAC75318 http://www.ensemblgenomes.org/id/AAC75318 EnsemblBacteria BAE76676 http://www.ensemblgenomes.org/id/BAE76676 EnsemblBacteria BAE76676 http://www.ensemblgenomes.org/id/BAE76676 EnsemblBacteria BAE76676 http://www.ensemblgenomes.org/id/BAE76676 EnsemblBacteria b2258 http://www.ensemblgenomes.org/id/b2258 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0022891 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022891 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GO_process GO:0009245 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009245 GO_process GO:0010041 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010041 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 945344 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945344 HAMAP MF_00538 http://hamap.expasy.org/unirule/MF_00538 HOGENOM HOG000261165 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261165&db=HOGENOM6 InParanoid P76474 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76474 InterPro IPR022832 http://www.ebi.ac.uk/interpro/entry/IPR022832 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Gene ecj:JW5373 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5373 KEGG_Gene eco:b2258 http://www.genome.jp/dbget-bin/www_bget?eco:b2258 KEGG_Orthology KO:K12963 http://www.genome.jp/dbget-bin/www_bget?KO:K12963 OMA VWLISRP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VWLISRP PSORT swissprot:ARNF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARNF_ECOLI PSORT-B swissprot:ARNF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARNF_ECOLI PSORT2 swissprot:ARNF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARNF_ECOLI Phobius swissprot:ARNF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARNF_ECOLI ProteinModelPortal P76474 http://www.proteinmodelportal.org/query/uniprot/P76474 PubMed 15569938 http://www.ncbi.nlm.nih.gov/pubmed/15569938 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17928292 http://www.ncbi.nlm.nih.gov/pubmed/17928292 PubMed 8626063 http://www.ncbi.nlm.nih.gov/pubmed/8626063 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416761 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416761 RefSeq WP_000523880 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000523880 SMR P76474 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76474 STRING 511145.b2258 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2258&targetmode=cogs STRING COG0697 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0697&targetmode=cogs TCDB 2.A.7.22 http://www.tcdb.org/search/result.php?tc=2.A.7.22 UniProtKB ARNF_ECOLI http://www.uniprot.org/uniprot/ARNF_ECOLI UniProtKB-AC P76474 http://www.uniprot.org/uniprot/P76474 charge swissprot:ARNF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARNF_ECOLI eggNOG COG0697 http://eggnogapi.embl.de/nog_data/html/tree/COG0697 eggNOG ENOG4105U65 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105U65 epestfind swissprot:ARNF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARNF_ECOLI garnier swissprot:ARNF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARNF_ECOLI helixturnhelix swissprot:ARNF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARNF_ECOLI hmoment swissprot:ARNF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARNF_ECOLI iep swissprot:ARNF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARNF_ECOLI inforesidue swissprot:ARNF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARNF_ECOLI octanol swissprot:ARNF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARNF_ECOLI pepcoil swissprot:ARNF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARNF_ECOLI pepdigest swissprot:ARNF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARNF_ECOLI pepinfo swissprot:ARNF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARNF_ECOLI pepnet swissprot:ARNF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARNF_ECOLI pepstats swissprot:ARNF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARNF_ECOLI pepwheel swissprot:ARNF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARNF_ECOLI pepwindow swissprot:ARNF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARNF_ECOLI sigcleave swissprot:ARNF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARNF_ECOLI ## Database ID URL or Descriptions # BioGrid 4261908 8 # EcoGene EG11775 ybfE # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:InterPro. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # INTERACTION YBFE_ECOLI Q46864 mqsA; NbExp=2; IntAct=EBI-9138393, EBI-1120353; # IntAct P0AAU7 3 # InterPro IPR002145 CopG # InterPro IPR010985 Ribbon_hlx_hlx # Organism YBFE_ECOLI Escherichia coli (strain K12) # PATRIC 32116563 VBIEscCol129921_0714 # PIR D64803 D64803 # Pfam PF01402 RHH_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBFE_ECOLI Uncharacterized protein YbfE # RefSeq NP_415211 NC_000913.3 # RefSeq WP_001300829 NZ_LN832404.1 # SUPFAM SSF47598 SSF47598 # eggNOG ENOG4105NNH Bacteria # eggNOG ENOG4111U4K LUCA BLAST swissprot:YBFE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBFE_ECOLI BioCyc ECOL316407:JW5816-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5816-MONOMER BioCyc EcoCyc:EG11775-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11775-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1724 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1724 EcoGene EG11775 http://www.ecogene.org/geneInfo.php?eg_id=EG11775 EnsemblBacteria AAC73779 http://www.ensemblgenomes.org/id/AAC73779 EnsemblBacteria AAC73779 http://www.ensemblgenomes.org/id/AAC73779 EnsemblBacteria BAA35334 http://www.ensemblgenomes.org/id/BAA35334 EnsemblBacteria BAA35334 http://www.ensemblgenomes.org/id/BAA35334 EnsemblBacteria BAA35334 http://www.ensemblgenomes.org/id/BAA35334 EnsemblBacteria b0685 http://www.ensemblgenomes.org/id/b0685 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 945291 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945291 HOGENOM HOG000275204 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275204&db=HOGENOM6 InParanoid P0AAU7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAU7 IntAct P0AAU7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAU7* InterPro IPR002145 http://www.ebi.ac.uk/interpro/entry/IPR002145 InterPro IPR010985 http://www.ebi.ac.uk/interpro/entry/IPR010985 KEGG_Gene ecj:JW5816 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5816 KEGG_Gene eco:b0685 http://www.genome.jp/dbget-bin/www_bget?eco:b0685 OMA NQIQRDR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NQIQRDR PSORT swissprot:YBFE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBFE_ECOLI PSORT-B swissprot:YBFE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBFE_ECOLI PSORT2 swissprot:YBFE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBFE_ECOLI Pfam PF01402 http://pfam.xfam.org/family/PF01402 Phobius swissprot:YBFE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBFE_ECOLI ProteinModelPortal P0AAU7 http://www.proteinmodelportal.org/query/uniprot/P0AAU7 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415211 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415211 RefSeq WP_001300829 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300829 STRING 511145.b0685 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0685&targetmode=cogs SUPFAM SSF47598 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47598 UniProtKB YBFE_ECOLI http://www.uniprot.org/uniprot/YBFE_ECOLI UniProtKB-AC P0AAU7 http://www.uniprot.org/uniprot/P0AAU7 charge swissprot:YBFE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBFE_ECOLI eggNOG ENOG4105NNH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105NNH eggNOG ENOG4111U4K http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111U4K epestfind swissprot:YBFE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBFE_ECOLI garnier swissprot:YBFE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBFE_ECOLI helixturnhelix swissprot:YBFE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBFE_ECOLI hmoment swissprot:YBFE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBFE_ECOLI iep swissprot:YBFE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBFE_ECOLI inforesidue swissprot:YBFE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBFE_ECOLI octanol swissprot:YBFE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBFE_ECOLI pepcoil swissprot:YBFE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBFE_ECOLI pepdigest swissprot:YBFE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBFE_ECOLI pepinfo swissprot:YBFE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBFE_ECOLI pepnet swissprot:YBFE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBFE_ECOLI pepstats swissprot:YBFE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBFE_ECOLI pepwheel swissprot:YBFE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBFE_ECOLI pepwindow swissprot:YBFE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBFE_ECOLI sigcleave swissprot:YBFE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBFE_ECOLI ## Database ID URL or Descriptions # AltName RIMM_ECOLI 21K # BioGrid 4263071 13 # DISRUPTION PHENOTYPE Disruption causes incomplete processing of 17S rRNA, accumulation of 30S and 50S subunits and decreased translational efficiency. Deletion is partially suppressed by mutations in rpsM, the gene for ribosomal protein S13, by a mutation in rpsS, the gene for S19 and also by overexpression of RbfA. Suppressors due to in-frame fusions with rpsP, the upstream gene for ribosomal protein S16 have been isolated. Suppression is probably due to increased expression of RimM; the fusion proteins are found in translationally active 70S ribosomes. {ECO:0000269|PubMed 9226267}. # DOMAIN RIMM_ECOLI The PRC barrel domain binds ribosomal protein S19. # EcoGene EG11153 rimM # FUNCTION RIMM_ECOLI An accessory protein needed during the final step in assembly of the 30S ribosomal subunit, probably for assembly of the head region (also called the 3' domain). It may act while Era is associated and after RimM in 30S subunit assembly. Interacts with S19. Essential for efficient processing of 16S rRNA; a deletion mutant accumulates 17S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes. {ECO 0000269|PubMed 20188109, ECO 0000269|PubMed 9226267, ECO 0000269|PubMed 9422595}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005840 ribosome; IEA:InterPro. # GO_function GO:0043022 ribosome binding; IEA:InterPro. # GO_process GO:0000028 ribosomal small subunit assembly; IMP:EcoCyc. # GO_process GO:0030490 maturation of SSU-rRNA; IMP:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005840 ribosome # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0022618 ribonucleoprotein complex assembly # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 2.40.30.60 -; 1. # HAMAP MF_00014 Ribosome_mat_RimM # INDUCTION RIMM_ECOLI Translation of the mRNA is repressed by a stem-loop in the first 150 nucleotides of the transcript. Part of the rpsP- rimM-trmD-rplS operon. # IntAct P0A7X6 7 # InterPro IPR002676 RimM # InterPro IPR009000 Transl_B-barrel # InterPro IPR011033 PRC_barrel-like # InterPro IPR011961 16S_RimM # InterPro IPR027275 PRC-brl_dom # KEGG_Brite ko03009 Ribosome biogenesis # Organism RIMM_ECOLI Escherichia coli (strain K12) # PATRIC 32120615 VBIEscCol129921_2706 # PIR C65039 C65039 # Pfam PF01782 RimM # Pfam PF05239 PRC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RIMM_ECOLI Ribosome maturation factor RimM # RefSeq NP_417099 NC_000913.3 # RefSeq WP_000043335 NZ_CP014272.1 # SIMILARITY Belongs to the RimM family. {ECO 0000305}. # SIMILARITY Contains 1 PRC barrel domain. {ECO 0000305}. # SUBCELLULAR LOCATION RIMM_ECOLI Cytoplasm {ECO 0000269|PubMed 11514519}. # SUBUNIT RIMM_ECOLI Binds ribosomal protein S19. # SUPFAM SSF50346 SSF50346 # SUPFAM SSF50447 SSF50447 # TIGRFAMs TIGR02273 16S_RimM # eggNOG COG0806 LUCA # eggNOG ENOG4108ZR6 Bacteria BLAST swissprot:RIMM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RIMM_ECOLI BioCyc ECOL316407:JW5413-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5413-MONOMER BioCyc EcoCyc:EG11153-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11153-MONOMER COG COG0806 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0806 DOI 10.1016/0022-2836(92)90462-S http://dx.doi.org/10.1016/0022-2836(92)90462-S DOI 10.1016/j.jmb.2010.02.036 http://dx.doi.org/10.1016/j.jmb.2010.02.036 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.183.18.5352-5357.2001 http://dx.doi.org/10.1128/JB.183.18.5352-5357.2001 DOI 10.1261/rna.7720204 http://dx.doi.org/10.1261/rna.7720204 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X01818 http://www.ebi.ac.uk/ena/data/view/X01818 EchoBASE EB1142 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1142 EcoGene EG11153 http://www.ecogene.org/geneInfo.php?eg_id=EG11153 EnsemblBacteria AAC75657 http://www.ensemblgenomes.org/id/AAC75657 EnsemblBacteria AAC75657 http://www.ensemblgenomes.org/id/AAC75657 EnsemblBacteria BAA16493 http://www.ensemblgenomes.org/id/BAA16493 EnsemblBacteria BAA16493 http://www.ensemblgenomes.org/id/BAA16493 EnsemblBacteria BAA16493 http://www.ensemblgenomes.org/id/BAA16493 EnsemblBacteria b2608 http://www.ensemblgenomes.org/id/b2608 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005840 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005840 GO_function GO:0043022 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043022 GO_process GO:0000028 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000028 GO_process GO:0030490 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030490 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005840 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005840 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0022618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022618 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 2.40.30.60 http://www.cathdb.info/version/latest/superfamily/2.40.30.60 GeneID 947101 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947101 HAMAP MF_00014 http://hamap.expasy.org/unirule/MF_00014 HOGENOM HOG000220989 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220989&db=HOGENOM6 InParanoid P0A7X6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7X6 IntAct P0A7X6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7X6* InterPro IPR002676 http://www.ebi.ac.uk/interpro/entry/IPR002676 InterPro IPR009000 http://www.ebi.ac.uk/interpro/entry/IPR009000 InterPro IPR011033 http://www.ebi.ac.uk/interpro/entry/IPR011033 InterPro IPR011961 http://www.ebi.ac.uk/interpro/entry/IPR011961 InterPro IPR027275 http://www.ebi.ac.uk/interpro/entry/IPR027275 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW5413 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5413 KEGG_Gene eco:b2608 http://www.genome.jp/dbget-bin/www_bget?eco:b2608 KEGG_Orthology KO:K02860 http://www.genome.jp/dbget-bin/www_bget?KO:K02860 OMA QPWFIQR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QPWFIQR PSORT swissprot:RIMM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RIMM_ECOLI PSORT-B swissprot:RIMM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RIMM_ECOLI PSORT2 swissprot:RIMM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RIMM_ECOLI Pfam PF01782 http://pfam.xfam.org/family/PF01782 Pfam PF05239 http://pfam.xfam.org/family/PF05239 Phobius swissprot:RIMM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RIMM_ECOLI PhylomeDB P0A7X6 http://phylomedb.org/?seqid=P0A7X6 ProteinModelPortal P0A7X6 http://www.proteinmodelportal.org/query/uniprot/P0A7X6 PubMed 11514519 http://www.ncbi.nlm.nih.gov/pubmed/11514519 PubMed 15496525 http://www.ncbi.nlm.nih.gov/pubmed/15496525 PubMed 1569581 http://www.ncbi.nlm.nih.gov/pubmed/1569581 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20188109 http://www.ncbi.nlm.nih.gov/pubmed/20188109 PubMed 6357787 http://www.ncbi.nlm.nih.gov/pubmed/6357787 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9226267 http://www.ncbi.nlm.nih.gov/pubmed/9226267 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9422595 http://www.ncbi.nlm.nih.gov/pubmed/9422595 RefSeq NP_417099 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417099 RefSeq WP_000043335 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000043335 SMR P0A7X6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7X6 STRING 511145.b2608 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2608&targetmode=cogs STRING COG0806 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0806&targetmode=cogs SUPFAM SSF50346 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50346 SUPFAM SSF50447 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50447 SWISS-2DPAGE P0A7X6 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A7X6 TIGRFAMs TIGR02273 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02273 UniProtKB RIMM_ECOLI http://www.uniprot.org/uniprot/RIMM_ECOLI UniProtKB-AC P0A7X6 http://www.uniprot.org/uniprot/P0A7X6 charge swissprot:RIMM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RIMM_ECOLI eggNOG COG0806 http://eggnogapi.embl.de/nog_data/html/tree/COG0806 eggNOG ENOG4108ZR6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZR6 epestfind swissprot:RIMM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RIMM_ECOLI garnier swissprot:RIMM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RIMM_ECOLI helixturnhelix swissprot:RIMM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RIMM_ECOLI hmoment swissprot:RIMM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RIMM_ECOLI iep swissprot:RIMM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RIMM_ECOLI inforesidue swissprot:RIMM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RIMM_ECOLI octanol swissprot:RIMM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RIMM_ECOLI pepcoil swissprot:RIMM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RIMM_ECOLI pepdigest swissprot:RIMM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RIMM_ECOLI pepinfo swissprot:RIMM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RIMM_ECOLI pepnet swissprot:RIMM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RIMM_ECOLI pepstats swissprot:RIMM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RIMM_ECOLI pepwheel swissprot:RIMM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RIMM_ECOLI pepwindow swissprot:RIMM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RIMM_ECOLI sigcleave swissprot:RIMM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RIMM_ECOLI ## Database ID URL or Descriptions # Organism YUBC_ECOLI Escherichia coli (strain K12) # RecName YUBC_ECOLI Uncharacterized protein YubC # RefSeq NP_061430 NC_002483.1 # RefSeq WP_010892536 NZ_CP014273.1 BLAST swissprot:YUBC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YUBC_ECOLI DOI 10.1006/plas.1999.1390 http://dx.doi.org/10.1006/plas.1999.1390 EMBL AF106329 http://www.ebi.ac.uk/ena/data/view/AF106329 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1263490 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263490 OMA CPASGWA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CPASGWA PSORT swissprot:YUBC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YUBC_ECOLI PSORT-B swissprot:YUBC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YUBC_ECOLI PSORT2 swissprot:YUBC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YUBC_ECOLI Phobius swissprot:YUBC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YUBC_ECOLI ProteinModelPortal Q9S4X3 http://www.proteinmodelportal.org/query/uniprot/Q9S4X3 PubMed 10366527 http://www.ncbi.nlm.nih.gov/pubmed/10366527 RefSeq NP_061430 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061430 RefSeq WP_010892536 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_010892536 SMR Q9S4X3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9S4X3 UniProtKB YUBC_ECOLI http://www.uniprot.org/uniprot/YUBC_ECOLI UniProtKB-AC Q9S4X3 http://www.uniprot.org/uniprot/Q9S4X3 charge swissprot:YUBC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YUBC_ECOLI epestfind swissprot:YUBC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YUBC_ECOLI garnier swissprot:YUBC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YUBC_ECOLI helixturnhelix swissprot:YUBC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YUBC_ECOLI hmoment swissprot:YUBC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YUBC_ECOLI iep swissprot:YUBC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YUBC_ECOLI inforesidue swissprot:YUBC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YUBC_ECOLI octanol swissprot:YUBC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YUBC_ECOLI pepcoil swissprot:YUBC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YUBC_ECOLI pepdigest swissprot:YUBC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YUBC_ECOLI pepinfo swissprot:YUBC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YUBC_ECOLI pepnet swissprot:YUBC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YUBC_ECOLI pepstats swissprot:YUBC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YUBC_ECOLI pepwheel swissprot:YUBC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YUBC_ECOLI pepwindow swissprot:YUBC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YUBC_ECOLI sigcleave swissprot:YUBC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YUBC_ECOLI ## Database ID URL or Descriptions # BioGrid 4262881 7 # EcoGene EG12674 uspF # GO_function GO:0005524 ATP binding; IDA:EcoliWiki. # GO_process GO:0006979 response to oxidative stress; IMP:EcoCyc. # GO_process GO:0007155 cell adhesion; IMP:EcoCyc. # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0007155 cell adhesion # Gene3D 3.40.50.620 -; 1. # IntAct P37903 19 # InterPro IPR006015 Universal_stress_UspA # InterPro IPR006016 UspA # InterPro IPR014729 Rossmann-like_a/b/a_fold # Organism USPF_ECOLI Escherichia coli (strain K12) # PATRIC 32118036 VBIEscCol129921_1438 # PIR C64888 C64888 # PRINTS PR01438 UNVRSLSTRESS # Pfam PF00582 Usp # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName USPF_ECOLI Universal stress protein F # RefSeq NP_415894 NC_000913.3 # RefSeq WP_001300461 NZ_LN832404.1 # SIMILARITY Belongs to the universal stress protein A family. {ECO 0000305}. # SUBUNIT Homodimer. {ECO 0000305}. # eggNOG COG0589 LUCA # eggNOG ENOG4108RW8 Bacteria BLAST swissprot:USPF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:USPF_ECOLI BioCyc ECOL316407:JW1370-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1370-MONOMER BioCyc EcoCyc:G6699-MONOMER http://biocyc.org/getid?id=EcoCyc:G6699-MONOMER COG COG0589 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0589 DIP DIP-12739N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12739N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2002.02720.x http://dx.doi.org/10.1046/j.1365-2958.2002.02720.x DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1110/ps.0217502 http://dx.doi.org/10.1110/ps.0217502 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2539 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2539 EcoGene EG12674 http://www.ecogene.org/geneInfo.php?eg_id=EG12674 EnsemblBacteria AAC74458 http://www.ensemblgenomes.org/id/AAC74458 EnsemblBacteria AAC74458 http://www.ensemblgenomes.org/id/AAC74458 EnsemblBacteria BAA14980 http://www.ensemblgenomes.org/id/BAA14980 EnsemblBacteria BAA14980 http://www.ensemblgenomes.org/id/BAA14980 EnsemblBacteria BAA14980 http://www.ensemblgenomes.org/id/BAA14980 EnsemblBacteria b1376 http://www.ensemblgenomes.org/id/b1376 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979 GO_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 GeneID 945948 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945948 HOGENOM HOG000238897 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000238897&db=HOGENOM6 InParanoid P37903 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37903 IntAct P37903 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37903* InterPro IPR006015 http://www.ebi.ac.uk/interpro/entry/IPR006015 InterPro IPR006016 http://www.ebi.ac.uk/interpro/entry/IPR006016 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 KEGG_Gene ecj:JW1370 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1370 KEGG_Gene eco:b1376 http://www.genome.jp/dbget-bin/www_bget?eco:b1376 KEGG_Orthology KO:K14061 http://www.genome.jp/dbget-bin/www_bget?KO:K14061 OMA KNWRTEK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KNWRTEK PRINTS PR01438 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01438 PSORT swissprot:USPF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:USPF_ECOLI PSORT-B swissprot:USPF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:USPF_ECOLI PSORT2 swissprot:USPF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:USPF_ECOLI Pfam PF00582 http://pfam.xfam.org/family/PF00582 Phobius swissprot:USPF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:USPF_ECOLI PhylomeDB P37903 http://phylomedb.org/?seqid=P37903 ProteinModelPortal P37903 http://www.proteinmodelportal.org/query/uniprot/P37903 PubMed 11849540 http://www.ncbi.nlm.nih.gov/pubmed/11849540 PubMed 12381839 http://www.ncbi.nlm.nih.gov/pubmed/12381839 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_415894 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415894 RefSeq WP_001300461 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300461 SMR P37903 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37903 STRING 511145.b1376 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1376&targetmode=cogs STRING COG0589 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0589&targetmode=cogs SWISS-2DPAGE P37903 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P37903 UniProtKB USPF_ECOLI http://www.uniprot.org/uniprot/USPF_ECOLI UniProtKB-AC P37903 http://www.uniprot.org/uniprot/P37903 charge swissprot:USPF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:USPF_ECOLI eggNOG COG0589 http://eggnogapi.embl.de/nog_data/html/tree/COG0589 eggNOG ENOG4108RW8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108RW8 epestfind swissprot:USPF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:USPF_ECOLI garnier swissprot:USPF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:USPF_ECOLI helixturnhelix swissprot:USPF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:USPF_ECOLI hmoment swissprot:USPF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:USPF_ECOLI iep swissprot:USPF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:USPF_ECOLI inforesidue swissprot:USPF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:USPF_ECOLI octanol swissprot:USPF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:USPF_ECOLI pepcoil swissprot:USPF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:USPF_ECOLI pepdigest swissprot:USPF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:USPF_ECOLI pepinfo swissprot:USPF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:USPF_ECOLI pepnet swissprot:USPF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:USPF_ECOLI pepstats swissprot:USPF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:USPF_ECOLI pepwheel swissprot:USPF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:USPF_ECOLI pepwindow swissprot:USPF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:USPF_ECOLI sigcleave swissprot:USPF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:USPF_ECOLI ## Database ID URL or Descriptions # BioGrid 4262826 7 # EcoGene EG10223 deoR # FUNCTION DEOR_ECOLI This protein is one of the repressors that regulate the expression of deoCABD genes, which encode nucleotide and deoxy ribonucleotide catabolizing enzymes. It also negatively regulates the expression of nupG (a transport protein) and tsx (a pore- forming protein). The inducer is deoxyribose-5-phosphate. # GO_component GO:0005622 intracellular; IEA:InterPro. # GO_function GO:0000986 bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding; IDA:EcoCyc. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:2000143 negative regulation of DNA-templated transcription, initiation; IMP:EcoCyc. # GOslim_component GO:0005622 intracellular # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # IntAct P0ACK5 4 # InterPro IPR001034 DeoR_HTH # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR014036 DeoR_C # InterPro IPR018356 Tscrpt_reg_HTH_DeoR_CS # KEGG_Brite ko03000 Transcription factors # Organism DEOR_ECOLI Escherichia coli (strain K12) # PATRIC 32116883 VBIEscCol129921_0867 # PIR A24076 RPECDO # PROSITE PS00894 HTH_DEOR_1 # PROSITE PS51000 HTH_DEOR_2 # Pfam PF00455 DeoRC # Pfam PF08220 HTH_DeoR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DEOR_ECOLI Deoxyribose operon repressor # RefSeq NP_415361 NC_000913.3 # RefSeq WP_000450121 NZ_LN832404.1 # SIMILARITY Contains 1 HTH deoR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00349}. # SMART SM00420 HTH_DEOR # SUBUNIT Homooctamer. {ECO:0000305|PubMed 2653814}. # eggNOG COG1349 LUCA # eggNOG ENOG4107FB0 Bacteria BLAST swissprot:DEOR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DEOR_ECOLI BioCyc ECOL316407:JW0824-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0824-MONOMER BioCyc EcoCyc:PD01196 http://biocyc.org/getid?id=EcoCyc:PD01196 COG COG1349 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1349 DIP DIP-9430N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9430N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/13.16.5927 http://dx.doi.org/10.1093/nar/13.16.5927 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X02837 http://www.ebi.ac.uk/ena/data/view/X02837 EchoBASE EB0219 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0219 EcoGene EG10223 http://www.ecogene.org/geneInfo.php?eg_id=EG10223 EnsemblBacteria AAC73927 http://www.ensemblgenomes.org/id/AAC73927 EnsemblBacteria AAC73927 http://www.ensemblgenomes.org/id/AAC73927 EnsemblBacteria BAA35543 http://www.ensemblgenomes.org/id/BAA35543 EnsemblBacteria BAA35543 http://www.ensemblgenomes.org/id/BAA35543 EnsemblBacteria BAA35543 http://www.ensemblgenomes.org/id/BAA35543 EnsemblBacteria b0840 http://www.ensemblgenomes.org/id/b0840 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_function GO:0000986 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000986 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:2000143 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000143 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 945453 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945453 HOGENOM HOG000267839 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267839&db=HOGENOM6 IntAct P0ACK5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACK5* InterPro IPR001034 http://www.ebi.ac.uk/interpro/entry/IPR001034 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR014036 http://www.ebi.ac.uk/interpro/entry/IPR014036 InterPro IPR018356 http://www.ebi.ac.uk/interpro/entry/IPR018356 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW0824 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0824 KEGG_Gene eco:b0840 http://www.genome.jp/dbget-bin/www_bget?eco:b0840 KEGG_Orthology KO:K11534 http://www.genome.jp/dbget-bin/www_bget?KO:K11534 OMA ELEMKHR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ELEMKHR PROSITE PS00894 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00894 PROSITE PS51000 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51000 PSORT swissprot:DEOR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DEOR_ECOLI PSORT-B swissprot:DEOR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DEOR_ECOLI PSORT2 swissprot:DEOR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DEOR_ECOLI Pfam PF00455 http://pfam.xfam.org/family/PF00455 Pfam PF08220 http://pfam.xfam.org/family/PF08220 Phobius swissprot:DEOR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DEOR_ECOLI PhylomeDB P0ACK5 http://phylomedb.org/?seqid=P0ACK5 ProteinModelPortal P0ACK5 http://www.proteinmodelportal.org/query/uniprot/P0ACK5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2653814 http://www.ncbi.nlm.nih.gov/pubmed/2653814 PubMed 2994018 http://www.ncbi.nlm.nih.gov/pubmed/2994018 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415361 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415361 RefSeq WP_000450121 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000450121 SMART SM00420 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00420 STRING 511145.b0840 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0840&targetmode=cogs STRING COG1349 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1349&targetmode=cogs UniProtKB DEOR_ECOLI http://www.uniprot.org/uniprot/DEOR_ECOLI UniProtKB-AC P0ACK5 http://www.uniprot.org/uniprot/P0ACK5 charge swissprot:DEOR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DEOR_ECOLI eggNOG COG1349 http://eggnogapi.embl.de/nog_data/html/tree/COG1349 eggNOG ENOG4107FB0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107FB0 epestfind swissprot:DEOR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DEOR_ECOLI garnier swissprot:DEOR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DEOR_ECOLI helixturnhelix swissprot:DEOR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DEOR_ECOLI hmoment swissprot:DEOR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DEOR_ECOLI iep swissprot:DEOR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DEOR_ECOLI inforesidue swissprot:DEOR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DEOR_ECOLI octanol swissprot:DEOR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DEOR_ECOLI pepcoil swissprot:DEOR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DEOR_ECOLI pepdigest swissprot:DEOR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DEOR_ECOLI pepinfo swissprot:DEOR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DEOR_ECOLI pepnet swissprot:DEOR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DEOR_ECOLI pepstats swissprot:DEOR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DEOR_ECOLI pepwheel swissprot:DEOR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DEOR_ECOLI pepwindow swissprot:DEOR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DEOR_ECOLI sigcleave swissprot:DEOR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DEOR_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES TRPE_ECOLI Kinetic parameters KM=1.2 uM for chorismate (at pH 7.5) {ECO 0000269|PubMed 4567790, ECO 0000269|PubMed 4886289, ECO 0000269|PubMed 5333199}; KM=15 mM for ammonia (at 37 degrees Celsius and at pH 7.6) {ECO 0000269|PubMed 4567790, ECO 0000269|PubMed 4886289, ECO 0000269|PubMed 5333199}; pH dependence Optimum pH is between 7.2 and 7.8. {ECO 0000269|PubMed 4567790, ECO 0000269|PubMed 4886289, ECO 0000269|PubMed 5333199}; # BioGrid 4260124 12 # CATALYTIC ACTIVITY Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate. {ECO:0000269|PubMed 4886289}. # COFACTOR TRPE_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250|UniProtKB P00897}; Note=Binds 1 Mg(2+) ion per subunit. {ECO 0000250|UniProtKB P00897}; # ENZYME REGULATION TRPE_ECOLI Cooperatively feedback inhibited by tryptophan. {ECO 0000269|PubMed 4567790, ECO 0000269|PubMed 4886289, ECO 0000269|PubMed 5333199}. # EcoGene EG11028 trpE # FUNCTION TRPE_ECOLI Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. {ECO 0000269|PubMed 4567790, ECO 0000269|PubMed 4886289, ECO 0000269|PubMed 5333199}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005950 anthranilate synthase complex; IBA:GO_Central. # GO_function GO:0004049 anthranilate synthase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0000162 tryptophan biosynthetic process; IDA:EcoCyc. # GO_process GO:0008652 cellular amino acid biosynthetic process; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.60.120.10 -; 1. # IntAct P00895 25 # InterPro IPR005257 Anth_synth_I_TrpE # InterPro IPR005801 ADC_synthase # InterPro IPR006805 Anth_synth_I_N # InterPro IPR015890 Chorismate_C # InterPro IPR019999 Anth_synth_I-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis # Organism TRPE_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-tryptophan biosynthesis; L- tryptophan from chorismate step 1/5. # PATRIC 32117788 VBIEscCol129921_1314 # PIR C64874 NNEC1 # PIRSF PIRSF001373 TrpE # PRINTS PR00095 ANTSNTHASEI # Pfam PF00425 Chorismate_bind # Pfam PF04715 Anth_synt_I_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TRPE_ECOLI Anthranilate synthase component 1 # RefSeq NP_415780 NC_000913.3 # RefSeq WP_001194582 NZ_LN832404.1 # SIMILARITY Belongs to the anthranilate synthase component I family. {ECO 0000305}. # SUBUNIT Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large lpha subunit (TrpE). {ECO 0000250}. # SUPFAM SSF56322 SSF56322 # TIGRFAMs TIGR00565 trpE_proteo # UniPathway UPA00035 UER00040 # eggNOG COG0147 LUCA # eggNOG ENOG4105CRQ Bacteria BLAST swissprot:TRPE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRPE_ECOLI BioCyc ECOL316407:JW1256-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1256-MONOMER BioCyc EcoCyc:ANTHRANSYNCOMPI-MONOMER http://biocyc.org/getid?id=EcoCyc:ANTHRANSYNCOMPI-MONOMER BioCyc MetaCyc:ANTHRANSYNCOMPI-MONOMER http://biocyc.org/getid?id=MetaCyc:ANTHRANSYNCOMPI-MONOMER COG COG0147 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0147 DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0022-2836(81)90365-X http://dx.doi.org/10.1016/0022-2836(81)90365-X DOI 10.1016/S0022-2836(78)80005-9 http://dx.doi.org/10.1016/S0022-2836(78)80005-9 DOI 10.1021/bi00705a028 http://dx.doi.org/10.1021/bi00705a028 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/9.24.6647 http://dx.doi.org/10.1093/nar/9.24.6647 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.1.3.27 http://www.genome.jp/dbget-bin/www_bget?EC:4.1.3.27 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01714 http://www.ebi.ac.uk/ena/data/view/J01714 EMBL M24959 http://www.ebi.ac.uk/ena/data/view/M24959 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00368 http://www.ebi.ac.uk/ena/data/view/V00368 EMBL V00372 http://www.ebi.ac.uk/ena/data/view/V00372 ENZYME 4.1.3.27 http://enzyme.expasy.org/EC/4.1.3.27 EchoBASE EB1021 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1021 EcoGene EG11028 http://www.ecogene.org/geneInfo.php?eg_id=EG11028 EnsemblBacteria AAC74346 http://www.ensemblgenomes.org/id/AAC74346 EnsemblBacteria AAC74346 http://www.ensemblgenomes.org/id/AAC74346 EnsemblBacteria BAA14799 http://www.ensemblgenomes.org/id/BAA14799 EnsemblBacteria BAA14799 http://www.ensemblgenomes.org/id/BAA14799 EnsemblBacteria BAA14799 http://www.ensemblgenomes.org/id/BAA14799 EnsemblBacteria b1264 http://www.ensemblgenomes.org/id/b1264 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005950 GO_function GO:0004049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004049 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0000162 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000162 GO_process GO:0008652 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008652 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.60.120.10 http://www.cathdb.info/version/latest/superfamily/3.60.120.10 GeneID 945846 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945846 HOGENOM HOG000025144 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000025144&db=HOGENOM6 InParanoid P00895 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00895 IntAct P00895 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00895* IntEnz 4.1.3.27 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.3.27 InterPro IPR005257 http://www.ebi.ac.uk/interpro/entry/IPR005257 InterPro IPR005801 http://www.ebi.ac.uk/interpro/entry/IPR005801 InterPro IPR006805 http://www.ebi.ac.uk/interpro/entry/IPR006805 InterPro IPR015890 http://www.ebi.ac.uk/interpro/entry/IPR015890 InterPro IPR019999 http://www.ebi.ac.uk/interpro/entry/IPR019999 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1256 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1256 KEGG_Gene eco:b1264 http://www.genome.jp/dbget-bin/www_bget?eco:b1264 KEGG_Orthology KO:K01657 http://www.genome.jp/dbget-bin/www_bget?KO:K01657 KEGG_Pathway ko00400 http://www.genome.jp/kegg-bin/show_pathway?ko00400 KEGG_Reaction rn:R00985 http://www.genome.jp/dbget-bin/www_bget?rn:R00985 KEGG_Reaction rn:R00986 http://www.genome.jp/dbget-bin/www_bget?rn:R00986 OMA MQDQDFT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MQDQDFT PRINTS PR00095 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00095 PSORT swissprot:TRPE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRPE_ECOLI PSORT-B swissprot:TRPE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRPE_ECOLI PSORT2 swissprot:TRPE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRPE_ECOLI Pfam PF00425 http://pfam.xfam.org/family/PF00425 Pfam PF04715 http://pfam.xfam.org/family/PF04715 Phobius swissprot:TRPE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRPE_ECOLI PhylomeDB P00895 http://phylomedb.org/?seqid=P00895 ProteinModelPortal P00895 http://www.proteinmodelportal.org/query/uniprot/P00895 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 351195 http://www.ncbi.nlm.nih.gov/pubmed/351195 PubMed 4567790 http://www.ncbi.nlm.nih.gov/pubmed/4567790 PubMed 4598537 http://www.ncbi.nlm.nih.gov/pubmed/4598537 PubMed 4886289 http://www.ncbi.nlm.nih.gov/pubmed/4886289 PubMed 5333199 http://www.ncbi.nlm.nih.gov/pubmed/5333199 PubMed 7021857 http://www.ncbi.nlm.nih.gov/pubmed/7021857 PubMed 7038627 http://www.ncbi.nlm.nih.gov/pubmed/7038627 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_415780 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415780 RefSeq WP_001194582 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001194582 SMR P00895 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00895 STRING 511145.b1264 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1264&targetmode=cogs STRING COG0147 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0147&targetmode=cogs SUPFAM SSF56322 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56322 TIGRFAMs TIGR00565 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00565 UniProtKB TRPE_ECOLI http://www.uniprot.org/uniprot/TRPE_ECOLI UniProtKB-AC P00895 http://www.uniprot.org/uniprot/P00895 charge swissprot:TRPE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRPE_ECOLI eggNOG COG0147 http://eggnogapi.embl.de/nog_data/html/tree/COG0147 eggNOG ENOG4105CRQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CRQ epestfind swissprot:TRPE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRPE_ECOLI garnier swissprot:TRPE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRPE_ECOLI helixturnhelix swissprot:TRPE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRPE_ECOLI hmoment swissprot:TRPE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRPE_ECOLI iep swissprot:TRPE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRPE_ECOLI inforesidue swissprot:TRPE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRPE_ECOLI octanol swissprot:TRPE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRPE_ECOLI pepcoil swissprot:TRPE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRPE_ECOLI pepdigest swissprot:TRPE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRPE_ECOLI pepinfo swissprot:TRPE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRPE_ECOLI pepnet swissprot:TRPE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRPE_ECOLI pepstats swissprot:TRPE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRPE_ECOLI pepwheel swissprot:TRPE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRPE_ECOLI pepwindow swissprot:TRPE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRPE_ECOLI sigcleave swissprot:TRPE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRPE_ECOLI ## Database ID URL or Descriptions # AltName D-Galf alpha-D-Glc beta-1,6-galactofuranosyltransferase # AltName WBBI_ECOLI GalF transferase # BioGrid 4261355 260 # EcoGene EG11983 yefG # FUNCTION WBBI_ECOLI Involved in the transfer of galactofuranose (Galf) onto an alpha-D-gluco-configured acceptor substrate to form a beta-1,6- linkage. It uses n-octyl alpha-D-glucopyranoside as an acceptor substrate for the addition of galactofuranose from the donor substrate UDP-galactofuranose. It is not able to use beta-D- glucopyranoside isomers. {ECO 0000269|PubMed 17047874}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0008921 lipopolysaccharide-1,6-galactosyltransferase activity; IDA:EcoCyc. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # IntAct P37749 2 # InterPro IPR016503 UDP-Galfuran_transf # Organism WBBI_ECOLI Escherichia coli (strain K12) # PATHWAY WBBI_ECOLI Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. # PATRIC 32119401 VBIEscCol129921_2110 # PIR I69645 I69645 # PIRSF PIRSF007023 UDP-Galf_transf # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName WBBI_ECOLI Beta-1,6-galactofuranosyltransferase WbbI # RefSeq NP_416538 NC_000913.3 # RefSeq WP_001407542 NZ_LN832404.1 # SUBCELLULAR LOCATION WBBI_ECOLI Cytoplasm {ECO 0000305}. # eggNOG ENOG4105GH9 Bacteria # eggNOG ENOG4111KQ1 LUCA BLAST swissprot:WBBI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:WBBI_ECOLI BioCyc ECOL316407:JW2019-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2019-MONOMER BioCyc EcoCyc:EG11983-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11983-MONOMER BioCyc MetaCyc:EG11983-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11983-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1039/b609455d http://dx.doi.org/10.1039/b609455d DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.4.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.4.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U03041 http://www.ebi.ac.uk/ena/data/view/U03041 EMBL U09876 http://www.ebi.ac.uk/ena/data/view/U09876 ENZYME 2.4.1.- http://enzyme.expasy.org/EC/2.4.1.- EchoBASE EB1926 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1926 EcoGene EG11983 http://www.ecogene.org/geneInfo.php?eg_id=EG11983 EnsemblBacteria AAC75095 http://www.ensemblgenomes.org/id/AAC75095 EnsemblBacteria AAC75095 http://www.ensemblgenomes.org/id/AAC75095 EnsemblBacteria BAA15876 http://www.ensemblgenomes.org/id/BAA15876 EnsemblBacteria BAA15876 http://www.ensemblgenomes.org/id/BAA15876 EnsemblBacteria BAA15876 http://www.ensemblgenomes.org/id/BAA15876 EnsemblBacteria b2034 http://www.ensemblgenomes.org/id/b2034 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0008921 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008921 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 947041 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947041 IntAct P37749 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37749* IntEnz 2.4.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.1 InterPro IPR016503 http://www.ebi.ac.uk/interpro/entry/IPR016503 KEGG_Gene ecj:JW2019 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2019 KEGG_Gene eco:b2034 http://www.genome.jp/dbget-bin/www_bget?eco:b2034 OMA THTIEPW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=THTIEPW PSORT swissprot:WBBI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:WBBI_ECOLI PSORT-B swissprot:WBBI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:WBBI_ECOLI PSORT2 swissprot:WBBI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:WBBI_ECOLI Phobius swissprot:WBBI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:WBBI_ECOLI ProteinModelPortal P37749 http://www.proteinmodelportal.org/query/uniprot/P37749 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17047874 http://www.ncbi.nlm.nih.gov/pubmed/17047874 PubMed 7517390 http://www.ncbi.nlm.nih.gov/pubmed/7517390 PubMed 7517391 http://www.ncbi.nlm.nih.gov/pubmed/7517391 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416538 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416538 RefSeq WP_001407542 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001407542 STRING 511145.b2034 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2034&targetmode=cogs UniProtKB WBBI_ECOLI http://www.uniprot.org/uniprot/WBBI_ECOLI UniProtKB-AC P37749 http://www.uniprot.org/uniprot/P37749 charge swissprot:WBBI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:WBBI_ECOLI eggNOG ENOG4105GH9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105GH9 eggNOG ENOG4111KQ1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111KQ1 epestfind swissprot:WBBI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:WBBI_ECOLI garnier swissprot:WBBI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:WBBI_ECOLI helixturnhelix swissprot:WBBI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:WBBI_ECOLI hmoment swissprot:WBBI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:WBBI_ECOLI iep swissprot:WBBI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:WBBI_ECOLI inforesidue swissprot:WBBI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:WBBI_ECOLI octanol swissprot:WBBI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:WBBI_ECOLI pepcoil swissprot:WBBI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:WBBI_ECOLI pepdigest swissprot:WBBI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:WBBI_ECOLI pepinfo swissprot:WBBI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:WBBI_ECOLI pepnet swissprot:WBBI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:WBBI_ECOLI pepstats swissprot:WBBI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:WBBI_ECOLI pepwheel swissprot:WBBI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:WBBI_ECOLI pepwindow swissprot:WBBI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:WBBI_ECOLI sigcleave swissprot:WBBI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:WBBI_ECOLI ## Database ID URL or Descriptions # BioGrid 4262384 174 # EcoGene EG14229 yqiH # FUNCTION YQIH_ECOLI Could be required for the biogenesis of a putative fimbria. {ECO 0000250}. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IEA:InterPro. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0043711 pilus organization; IEA:InterPro. # GO_process GO:0061077 chaperone-mediated protein folding; IEA:InterPro. # GO_process GO:0071555 cell wall organization; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0006457 protein folding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 2.60.40.1070 -; 1. # Gene3D 2.60.40.360 -; 1. # InterPro IPR001829 Pili_assmbl_chaperone_bac # InterPro IPR008962 PapD-like # InterPro IPR016147 Pili_assmbl_chaperone_N # InterPro IPR016148 Pili_assmbl_chaperone_C # InterPro IPR018046 Pili_assmbl_chaperone_CS # Organism YQIH_ECOLI Escherichia coli (strain K12) # PATRIC 32121506 VBIEscCol129921_3140 # PIR E65092 E65092 # PRINTS PR00969 CHAPERONPILI # PROSITE PS00635 PILI_CHAPERONE # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF00345 PapD_N # Pfam PF02753 PapD_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQIH_ECOLI Uncharacterized fimbrial chaperone YqiH # RefSeq NP_417519 NC_000913.3 # RefSeq WP_001269824 NZ_LN832404.1 # SIMILARITY Belongs to the periplasmic pilus chaperone family. {ECO 0000305}. # SIMILARITY Contains 1 Ig-like (immunoglobulin-like) domain. {ECO 0000305}. # SUBCELLULAR LOCATION YQIH_ECOLI Periplasm {ECO 0000250}. # SUPFAM SSF49354 SSF49354 # SUPFAM SSF49584 SSF49584 # eggNOG ENOG4108TTM Bacteria # eggNOG ENOG4111FN8 LUCA BLAST swissprot:YQIH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQIH_ECOLI BioCyc ECOL316407:JW5508-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5508-MONOMER BioCyc EcoCyc:G7586-MONOMER http://biocyc.org/getid?id=EcoCyc:G7586-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3980 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3980 EcoGene EG14229 http://www.ecogene.org/geneInfo.php?eg_id=EG14229 EnsemblBacteria AAC76083 http://www.ensemblgenomes.org/id/AAC76083 EnsemblBacteria AAC76083 http://www.ensemblgenomes.org/id/AAC76083 EnsemblBacteria BAA16576 http://www.ensemblgenomes.org/id/BAA16576 EnsemblBacteria BAA16576 http://www.ensemblgenomes.org/id/BAA16576 EnsemblBacteria BAA16576 http://www.ensemblgenomes.org/id/BAA16576 EnsemblBacteria b3047 http://www.ensemblgenomes.org/id/b3047 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0043711 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043711 GO_process GO:0061077 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061077 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 2.60.40.1070 http://www.cathdb.info/version/latest/superfamily/2.60.40.1070 Gene3D 2.60.40.360 http://www.cathdb.info/version/latest/superfamily/2.60.40.360 GeneID 947531 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947531 HOGENOM HOG000260153 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260153&db=HOGENOM6 InterPro IPR001829 http://www.ebi.ac.uk/interpro/entry/IPR001829 InterPro IPR008962 http://www.ebi.ac.uk/interpro/entry/IPR008962 InterPro IPR016147 http://www.ebi.ac.uk/interpro/entry/IPR016147 InterPro IPR016148 http://www.ebi.ac.uk/interpro/entry/IPR016148 InterPro IPR018046 http://www.ebi.ac.uk/interpro/entry/IPR018046 KEGG_Gene ecj:JW5508 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5508 KEGG_Gene eco:b3047 http://www.genome.jp/dbget-bin/www_bget?eco:b3047 OMA FSHADTQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FSHADTQ PRINTS PR00969 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00969 PROSITE PS00635 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00635 PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YQIH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQIH_ECOLI PSORT-B swissprot:YQIH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQIH_ECOLI PSORT2 swissprot:YQIH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQIH_ECOLI Pfam PF00345 http://pfam.xfam.org/family/PF00345 Pfam PF02753 http://pfam.xfam.org/family/PF02753 Phobius swissprot:YQIH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQIH_ECOLI PhylomeDB P77616 http://phylomedb.org/?seqid=P77616 ProteinModelPortal P77616 http://www.proteinmodelportal.org/query/uniprot/P77616 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417519 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417519 RefSeq WP_001269824 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001269824 SMR P77616 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77616 STRING 511145.b3047 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3047&targetmode=cogs SUPFAM SSF49354 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49354 SUPFAM SSF49584 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49584 UniProtKB YQIH_ECOLI http://www.uniprot.org/uniprot/YQIH_ECOLI UniProtKB-AC P77616 http://www.uniprot.org/uniprot/P77616 charge swissprot:YQIH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQIH_ECOLI eggNOG ENOG4108TTM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108TTM eggNOG ENOG4111FN8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111FN8 epestfind swissprot:YQIH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQIH_ECOLI garnier swissprot:YQIH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQIH_ECOLI helixturnhelix swissprot:YQIH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQIH_ECOLI hmoment swissprot:YQIH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQIH_ECOLI iep swissprot:YQIH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQIH_ECOLI inforesidue swissprot:YQIH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQIH_ECOLI octanol swissprot:YQIH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQIH_ECOLI pepcoil swissprot:YQIH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQIH_ECOLI pepdigest swissprot:YQIH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQIH_ECOLI pepinfo swissprot:YQIH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQIH_ECOLI pepnet swissprot:YQIH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQIH_ECOLI pepstats swissprot:YQIH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQIH_ECOLI pepwheel swissprot:YQIH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQIH_ECOLI pepwindow swissprot:YQIH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQIH_ECOLI sigcleave swissprot:YQIH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQIH_ECOLI ## Database ID URL or Descriptions # AltName BRNQ_ECOLI LIV-II # BioGrid 4259819 6 # EcoGene EG12168 brnQ # FUNCTION BRNQ_ECOLI Component of the LIV-II transport system for branched- chain amino acids. This LIV-II transport system may be H(+)- coupled. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005304 L-valine transmembrane transporter activity; IMP:EcoCyc. # GO_function GO:0015188 L-isoleucine transmembrane transporter activity; IMP:EcoCyc. # GO_function GO:0015190 L-leucine transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0015803 branched-chain amino acid transport; IMP:EcoliWiki. # GO_process GO:0015818 isoleucine transport; IMP:EcoliWiki. # GO_process GO:0015820 leucine transport; IMP:EcoliWiki. # GO_process GO:0015829 valine transport; IMP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # INTERACTION BRNQ_ECOLI P08312 pheS; NbExp=3; IntAct=EBI-555687, EBI-555676; # InterPro IPR004685 Brnchd-chn_aa_trnsp_Livcs # Organism BRNQ_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30588 PTHR30588 # PATRIC 32115951 VBIEscCol129921_0417 # PIR A64769 A64769 # Pfam PF05525 Branch_AA_trans # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BRNQ_ECOLI Branched-chain amino acid transport system 2 carrier protein # RefSeq NP_414935 NC_000913.3 # RefSeq WP_000149639 NZ_LN832404.1 # SIMILARITY Belongs to the branched chain amino acid transporter family. {ECO 0000305}. # SUBCELLULAR LOCATION BRNQ_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.26.1.10:the branched chain amino acid cation symporter (livcs) family # TIGRFAMs TIGR00796 livcs # eggNOG COG1114 LUCA # eggNOG ENOG4105CWM Bacteria BLAST swissprot:BRNQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BRNQ_ECOLI BioCyc ECOL316407:JW0391-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0391-MONOMER BioCyc EcoCyc:BRNQ-MONOMER http://biocyc.org/getid?id=EcoCyc:BRNQ-MONOMER BioCyc MetaCyc:BRNQ-MONOMER http://biocyc.org/getid?id=MetaCyc:BRNQ-MONOMER COG COG1114 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1114 DIP DIP-48078N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48078N DOI 10.1016/0022-2836(86)90275-5 http://dx.doi.org/10.1016/0022-2836(86)90275-5 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL X04704 http://www.ebi.ac.uk/ena/data/view/X04704 EchoBASE EB2087 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2087 EcoGene EG12168 http://www.ecogene.org/geneInfo.php?eg_id=EG12168 EnsemblBacteria AAC73504 http://www.ensemblgenomes.org/id/AAC73504 EnsemblBacteria AAC73504 http://www.ensemblgenomes.org/id/AAC73504 EnsemblBacteria BAE76181 http://www.ensemblgenomes.org/id/BAE76181 EnsemblBacteria BAE76181 http://www.ensemblgenomes.org/id/BAE76181 EnsemblBacteria BAE76181 http://www.ensemblgenomes.org/id/BAE76181 EnsemblBacteria b0401 http://www.ensemblgenomes.org/id/b0401 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005304 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005304 GO_function GO:0015188 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015188 GO_function GO:0015190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015190 GO_process GO:0015803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015803 GO_process GO:0015818 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015818 GO_process GO:0015820 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015820 GO_process GO:0015829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015829 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 945042 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945042 HOGENOM HOG000270688 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000270688&db=HOGENOM6 InParanoid P0AD99 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AD99 IntAct P0AD99 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AD99* InterPro IPR004685 http://www.ebi.ac.uk/interpro/entry/IPR004685 KEGG_Gene ecj:JW0391 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0391 KEGG_Gene eco:b0401 http://www.genome.jp/dbget-bin/www_bget?eco:b0401 KEGG_Orthology KO:K03311 http://www.genome.jp/dbget-bin/www_bget?KO:K03311 MINT MINT-1238115 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1238115 OMA YSLIYFA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YSLIYFA PANTHER PTHR30588 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30588 PSORT swissprot:BRNQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BRNQ_ECOLI PSORT-B swissprot:BRNQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BRNQ_ECOLI PSORT2 swissprot:BRNQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BRNQ_ECOLI Pfam PF05525 http://pfam.xfam.org/family/PF05525 Phobius swissprot:BRNQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BRNQ_ECOLI PhylomeDB P0AD99 http://phylomedb.org/?seqid=P0AD99 ProteinModelPortal P0AD99 http://www.proteinmodelportal.org/query/uniprot/P0AD99 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3550103 http://www.ncbi.nlm.nih.gov/pubmed/3550103 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414935 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414935 RefSeq WP_000149639 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000149639 STRING 511145.b0401 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0401&targetmode=cogs STRING COG1114 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1114&targetmode=cogs TCDB 2.A.26.1.10 http://www.tcdb.org/search/result.php?tc=2.A.26.1.10 TIGRFAMs TIGR00796 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00796 UniProtKB BRNQ_ECOLI http://www.uniprot.org/uniprot/BRNQ_ECOLI UniProtKB-AC P0AD99 http://www.uniprot.org/uniprot/P0AD99 charge swissprot:BRNQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BRNQ_ECOLI eggNOG COG1114 http://eggnogapi.embl.de/nog_data/html/tree/COG1114 eggNOG ENOG4105CWM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CWM epestfind swissprot:BRNQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BRNQ_ECOLI garnier swissprot:BRNQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BRNQ_ECOLI helixturnhelix swissprot:BRNQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BRNQ_ECOLI hmoment swissprot:BRNQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BRNQ_ECOLI iep swissprot:BRNQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BRNQ_ECOLI inforesidue swissprot:BRNQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BRNQ_ECOLI octanol swissprot:BRNQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BRNQ_ECOLI pepcoil swissprot:BRNQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BRNQ_ECOLI pepdigest swissprot:BRNQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BRNQ_ECOLI pepinfo swissprot:BRNQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BRNQ_ECOLI pepnet swissprot:BRNQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BRNQ_ECOLI pepstats swissprot:BRNQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BRNQ_ECOLI pepwheel swissprot:BRNQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BRNQ_ECOLI pepwindow swissprot:BRNQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BRNQ_ECOLI sigcleave swissprot:BRNQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BRNQ_ECOLI ## Database ID URL or Descriptions # CDD cd08071 MPN_DUF2466 # EcoGene EG13211 yfjY # IntAct P52140 6 # InterPro IPR001405 RadC # InterPro IPR020891 UPF0758_CS # InterPro IPR025657 RadC_JAB # Organism YFJY_ECOLI Escherichia coli (strain K12) # PATRIC 32120681 VBIEscCol129921_2739 # PIR T08655 T08655 # PROSITE PS01302 UPF0758 # Pfam PF04002 RadC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFJY_ECOLI UPF0758 protein YfjY # RefSeq NP_417131 NC_000913.3 # RefSeq WP_001407480 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0758 family. {ECO 0000305}. # TIGRFAMs TIGR00608 radc # eggNOG COG2003 LUCA # eggNOG ENOG4108XS9 Bacteria BLAST swissprot:YFJY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFJY_ECOLI BioCyc ECOL316407:JW2625-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2625-MONOMER BioCyc EcoCyc:G7379-MONOMER http://biocyc.org/getid?id=EcoCyc:G7379-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36840 http://www.ebi.ac.uk/ena/data/view/U36840 EchoBASE EB3003 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3003 EcoGene EG13211 http://www.ecogene.org/geneInfo.php?eg_id=EG13211 EnsemblBacteria AAC75692 http://www.ensemblgenomes.org/id/AAC75692 EnsemblBacteria AAC75692 http://www.ensemblgenomes.org/id/AAC75692 EnsemblBacteria BAA16512 http://www.ensemblgenomes.org/id/BAA16512 EnsemblBacteria BAA16512 http://www.ensemblgenomes.org/id/BAA16512 EnsemblBacteria BAA16512 http://www.ensemblgenomes.org/id/BAA16512 EnsemblBacteria b2644 http://www.ensemblgenomes.org/id/b2644 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947125 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947125 HOGENOM HOG000273376 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000273376&db=HOGENOM6 InParanoid P52140 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P52140 IntAct P52140 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P52140* InterPro IPR001405 http://www.ebi.ac.uk/interpro/entry/IPR001405 InterPro IPR020891 http://www.ebi.ac.uk/interpro/entry/IPR020891 InterPro IPR025657 http://www.ebi.ac.uk/interpro/entry/IPR025657 KEGG_Gene ecj:JW2625 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2625 KEGG_Gene eco:b2644 http://www.genome.jp/dbget-bin/www_bget?eco:b2644 OMA ILDEKVM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ILDEKVM PROSITE PS01302 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01302 PSORT swissprot:YFJY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFJY_ECOLI PSORT-B swissprot:YFJY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFJY_ECOLI PSORT2 swissprot:YFJY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFJY_ECOLI Pfam PF04002 http://pfam.xfam.org/family/PF04002 Phobius swissprot:YFJY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFJY_ECOLI PhylomeDB P52140 http://phylomedb.org/?seqid=P52140 ProteinModelPortal P52140 http://www.proteinmodelportal.org/query/uniprot/P52140 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417131 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417131 RefSeq WP_001407480 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001407480 SMR P52140 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P52140 STRING 511145.b2644 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2644&targetmode=cogs TIGRFAMs TIGR00608 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00608 UniProtKB YFJY_ECOLI http://www.uniprot.org/uniprot/YFJY_ECOLI UniProtKB-AC P52140 http://www.uniprot.org/uniprot/P52140 charge swissprot:YFJY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFJY_ECOLI eggNOG COG2003 http://eggnogapi.embl.de/nog_data/html/tree/COG2003 eggNOG ENOG4108XS9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108XS9 epestfind swissprot:YFJY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFJY_ECOLI garnier swissprot:YFJY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFJY_ECOLI helixturnhelix swissprot:YFJY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFJY_ECOLI hmoment swissprot:YFJY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFJY_ECOLI iep swissprot:YFJY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFJY_ECOLI inforesidue swissprot:YFJY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFJY_ECOLI octanol swissprot:YFJY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFJY_ECOLI pepcoil swissprot:YFJY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFJY_ECOLI pepdigest swissprot:YFJY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFJY_ECOLI pepinfo swissprot:YFJY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFJY_ECOLI pepnet swissprot:YFJY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFJY_ECOLI pepstats swissprot:YFJY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFJY_ECOLI pepwheel swissprot:YFJY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFJY_ECOLI pepwindow swissprot:YFJY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFJY_ECOLI sigcleave swissprot:YFJY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFJY_ECOLI ## Database ID URL or Descriptions # BioGrid 4260774 363 # DISRUPTION PHENOTYPE Inactivation results in a filamented cellular morphology, but not in a temperature-sensitive phenotype. {ECO:0000269|PubMed 10048040}. # EcoGene EG10340 ftsE # FUNCTION FTSE_ECOLI Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring. {ECO 0000269|PubMed 14729705}. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0019898 extrinsic component of membrane; IDA:EcoliWiki. # GO_component GO:0031234 extrinsic component of cytoplasmic side of plasma membrane; IDA:EcoCyc. # GO_component GO:0032153 cell division site; IDA:EcoliWiki. # GO_function GO:0005524 ATP binding; IDA:EcoliWiki. # GO_function GO:0016887 ATPase activity; IEA:InterPro. # GO_process GO:0007049 cell cycle; IEA:UniProtKB-KW. # GO_process GO:0046677 response to antibiotic; IMP:EcoliWiki. # GO_process GO:0051301 cell division; IMP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0007049 cell cycle # GOslim_process GO:0008150 biological_process # GOslim_process GO:0051301 cell division # Gene3D 3.40.50.300 -; 1. # INTERACTION FTSE_ECOLI P0A9A6 ftsZ; NbExp=2; IntAct=EBI-550637, EBI-370963; # IntAct P0A9R7 27 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR005286 Cell_div_FtsE_ATP-bd # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00256 Cell division transport system # KEGG_Brite ko02000 Transporters # KEGG_Brite ko02044 Secretion system # KEGG_Brite ko03036 Chromosome # KEGG_Pathway ko02010 ABC transporters # Organism FTSE_ECOLI Escherichia coli (strain K12) # PATRIC 32122370 VBIEscCol129921_3562 # PIR S03131 CEECFE # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # Pfam PF00005 ABC_tran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Cell division ATP-binding protein FtsE {ECO 0000305} # RefSeq NP_417920 NC_000913.3 # RefSeq WP_000617723 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA # SUBCELLULAR LOCATION FTSE_ECOLI Cell inner membrane {ECO 0000269|PubMed 10048040, ECO 0000269|PubMed 3323846}; Peripheral membrane protein {ECO 0000269|PubMed 10048040}; Cytoplasmic side {ECO 0000305}. Note=Associated with the membrane through an interaction with FtsX (PubMed 10048040). Localizes to the septal ring at the later stages of cell growth and remains there until division is complete (PubMed 14729705). This localization is dependent on localization of FtsZ, FtsA and ZipA, but not on the downstream division proteins FtsK, FtsQ or FtsI (PubMed 14729705). {ECO 0000269|PubMed 10048040, ECO 0000269|PubMed 14729705}. # SUBUNIT FTSE_ECOLI Homodimer (PubMed 10048040). Forms a membrane-associated complex with FtsX (PubMed 10048040). Interacts with FtsZ, independently of FtsX, FtsA or ZipA (PubMed 17307852). {ECO 0000269|PubMed 10048040, ECO 0000269|PubMed 17307852}. # SUPFAM SSF52540 SSF52540 # TCDB 3.A.1.140 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR02673 FtsE # eggNOG COG2884 LUCA # eggNOG ENOG4105CAK Bacteria BLAST swissprot:FTSE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FTSE_ECOLI BioCyc ECOL316407:JW3428-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3428-MONOMER BioCyc EcoCyc:FTSE-MONOMER http://biocyc.org/getid?id=EcoCyc:FTSE-MONOMER COG COG2884 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2884 DIP DIP-47843N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47843N DOI 10.1007/BF00327204 http://dx.doi.org/10.1007/BF00327204 DOI 10.1007/BF02428043 http://dx.doi.org/10.1007/BF02428043 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1999.01245.x http://dx.doi.org/10.1046/j.1365-2958.1999.01245.x DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01581-06 http://dx.doi.org/10.1128/JB.01581-06 DOI 10.1128/JB.186.3.785-793.2004 http://dx.doi.org/10.1128/JB.186.3.785-793.2004 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X04398 http://www.ebi.ac.uk/ena/data/view/X04398 EchoBASE EB0336 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0336 EcoGene EG10340 http://www.ecogene.org/geneInfo.php?eg_id=EG10340 EnsemblBacteria AAC76488 http://www.ensemblgenomes.org/id/AAC76488 EnsemblBacteria AAC76488 http://www.ensemblgenomes.org/id/AAC76488 EnsemblBacteria BAE77830 http://www.ensemblgenomes.org/id/BAE77830 EnsemblBacteria BAE77830 http://www.ensemblgenomes.org/id/BAE77830 EnsemblBacteria BAE77830 http://www.ensemblgenomes.org/id/BAE77830 EnsemblBacteria b3463 http://www.ensemblgenomes.org/id/b3463 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0019898 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019898 GO_component GO:0031234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031234 GO_component GO:0032153 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032153 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947968 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947968 InParanoid P0A9R7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9R7 IntAct P0A9R7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9R7* InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR005286 http://www.ebi.ac.uk/interpro/entry/IPR005286 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene ecj:JW3428 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3428 KEGG_Gene eco:b3463 http://www.genome.jp/dbget-bin/www_bget?eco:b3463 KEGG_Orthology KO:K09812 http://www.genome.jp/dbget-bin/www_bget?KO:K09812 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 MINT MINT-1233007 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1233007 OMA YTHKEIR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YTHKEIR PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:FTSE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FTSE_ECOLI PSORT-B swissprot:FTSE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FTSE_ECOLI PSORT2 swissprot:FTSE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FTSE_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Phobius swissprot:FTSE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FTSE_ECOLI PhylomeDB P0A9R7 http://phylomedb.org/?seqid=P0A9R7 ProteinModelPortal P0A9R7 http://www.proteinmodelportal.org/query/uniprot/P0A9R7 PubMed 10048040 http://www.ncbi.nlm.nih.gov/pubmed/10048040 PubMed 14729705 http://www.ncbi.nlm.nih.gov/pubmed/14729705 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17307852 http://www.ncbi.nlm.nih.gov/pubmed/17307852 PubMed 3025556 http://www.ncbi.nlm.nih.gov/pubmed/3025556 PubMed 3323846 http://www.ncbi.nlm.nih.gov/pubmed/3323846 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417920 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417920 RefSeq WP_000617723 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000617723 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P0A9R7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9R7 STRING 511145.b3463 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3463&targetmode=cogs STRING COG2884 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2884&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.140 http://www.tcdb.org/search/result.php?tc=3.A.1.140 TIGRFAMs TIGR02673 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02673 UniProtKB FTSE_ECOLI http://www.uniprot.org/uniprot/FTSE_ECOLI UniProtKB-AC P0A9R7 http://www.uniprot.org/uniprot/P0A9R7 charge swissprot:FTSE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FTSE_ECOLI eggNOG COG2884 http://eggnogapi.embl.de/nog_data/html/tree/COG2884 eggNOG ENOG4105CAK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CAK epestfind swissprot:FTSE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FTSE_ECOLI garnier swissprot:FTSE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FTSE_ECOLI helixturnhelix swissprot:FTSE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FTSE_ECOLI hmoment swissprot:FTSE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FTSE_ECOLI iep swissprot:FTSE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FTSE_ECOLI inforesidue swissprot:FTSE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FTSE_ECOLI octanol swissprot:FTSE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FTSE_ECOLI pepcoil swissprot:FTSE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FTSE_ECOLI pepdigest swissprot:FTSE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FTSE_ECOLI pepinfo swissprot:FTSE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FTSE_ECOLI pepnet swissprot:FTSE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FTSE_ECOLI pepstats swissprot:FTSE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FTSE_ECOLI pepwheel swissprot:FTSE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FTSE_ECOLI pepwindow swissprot:FTSE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FTSE_ECOLI sigcleave swissprot:FTSE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FTSE_ECOLI ## Database ID URL or Descriptions # BioGrid 4260620 11 # EcoGene EG12442 yfjD # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0016614 oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro. # GO_function GO:0050660 flavin adenine dinucleotide binding; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # Gene3D 3.30.465.10 -; 1. # IntAct P37908 2 # InterPro IPR000644 CBS_dom # InterPro IPR002550 DUF21 # InterPro IPR005170 Transptr-assoc_dom # InterPro IPR016166 FAD-bd_2 # InterPro IPR016169 CO_DH_flavot_FAD-bd_sub2 # Organism YFJD_ECOLI Escherichia coli (strain K12) # PATRIC 32120623 VBIEscCol129921_2710 # PROSITE PS51371 CBS # Pfam PF00571 CBS # Pfam PF01595 DUF21 # Pfam PF03471 CorC_HlyC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFJD_ECOLI UPF0053 inner membrane protein YfjD # RefSeq YP_026171 NC_000913.3 # SEQUENCE CAUTION Sequence=BAA16497.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=X07863; Type=Frameshift; Positions=326, 331, 348; Evidence={ECO 0000305}; # SIMILARITY Belongs to the UPF0053 family. {ECO 0000305}. # SIMILARITY Contains 1 DUF21 domain. {ECO 0000305}. # SIMILARITY Contains 2 CBS domains. {ECO:0000255|PROSITE- ProRule PRU00703}. # SMART SM01091 CorC_HlyC # SUBCELLULAR LOCATION YFJD_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF56176 SSF56176 # TCDB 9.A.40.2 the hlyc/corc (hcc) family # eggNOG COG4536 LUCA # eggNOG ENOG4108JU6 Bacteria BLAST swissprot:YFJD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFJD_ECOLI BioCyc ECOL316407:JW5415-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5415-MONOMER BioCyc EcoCyc:G7356-MONOMER http://biocyc.org/getid?id=EcoCyc:G7356-MONOMER DIP DIP-12070N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12070N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/nar/16.15.7545 http://dx.doi.org/10.1093/nar/16.15.7545 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X07863 http://www.ebi.ac.uk/ena/data/view/X07863 EchoBASE EB2336 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2336 EcoGene EG12442 http://www.ecogene.org/geneInfo.php?eg_id=EG12442 EnsemblBacteria AAT48144 http://www.ensemblgenomes.org/id/AAT48144 EnsemblBacteria AAT48144 http://www.ensemblgenomes.org/id/AAT48144 EnsemblBacteria BAA16497 http://www.ensemblgenomes.org/id/BAA16497 EnsemblBacteria BAA16497 http://www.ensemblgenomes.org/id/BAA16497 EnsemblBacteria BAA16497 http://www.ensemblgenomes.org/id/BAA16497 EnsemblBacteria b4461 http://www.ensemblgenomes.org/id/b4461 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0016614 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016614 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.30.465.10 http://www.cathdb.info/version/latest/superfamily/3.30.465.10 GeneID 2847739 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2847739 HOGENOM HOG000062298 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000062298&db=HOGENOM6 InParanoid P37908 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37908 IntAct P37908 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37908* InterPro IPR000644 http://www.ebi.ac.uk/interpro/entry/IPR000644 InterPro IPR002550 http://www.ebi.ac.uk/interpro/entry/IPR002550 InterPro IPR005170 http://www.ebi.ac.uk/interpro/entry/IPR005170 InterPro IPR016166 http://www.ebi.ac.uk/interpro/entry/IPR016166 InterPro IPR016169 http://www.ebi.ac.uk/interpro/entry/IPR016169 KEGG_Gene ecj:JW5415 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5415 KEGG_Gene eco:b4461 http://www.genome.jp/dbget-bin/www_bget?eco:b4461 MINT MINT-1274766 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1274766 OMA PYTRMPL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PYTRMPL PROSITE PS51371 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51371 PSORT swissprot:YFJD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFJD_ECOLI PSORT-B swissprot:YFJD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFJD_ECOLI PSORT2 swissprot:YFJD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFJD_ECOLI Pfam PF00571 http://pfam.xfam.org/family/PF00571 Pfam PF01595 http://pfam.xfam.org/family/PF01595 Pfam PF03471 http://pfam.xfam.org/family/PF03471 Phobius swissprot:YFJD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFJD_ECOLI PhylomeDB P37908 http://phylomedb.org/?seqid=P37908 ProteinModelPortal P37908 http://www.proteinmodelportal.org/query/uniprot/P37908 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3045760 http://www.ncbi.nlm.nih.gov/pubmed/3045760 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq YP_026171 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026171 SMART SM01091 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01091 SMR P37908 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37908 STRING 511145.b4461 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4461&targetmode=cogs SUPFAM SSF56176 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56176 TCDB 9.A.40.2 http://www.tcdb.org/search/result.php?tc=9.A.40.2 UniProtKB YFJD_ECOLI http://www.uniprot.org/uniprot/YFJD_ECOLI UniProtKB-AC P37908 http://www.uniprot.org/uniprot/P37908 charge swissprot:YFJD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFJD_ECOLI eggNOG COG4536 http://eggnogapi.embl.de/nog_data/html/tree/COG4536 eggNOG ENOG4108JU6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108JU6 epestfind swissprot:YFJD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFJD_ECOLI garnier swissprot:YFJD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFJD_ECOLI helixturnhelix swissprot:YFJD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFJD_ECOLI hmoment swissprot:YFJD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFJD_ECOLI iep swissprot:YFJD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFJD_ECOLI inforesidue swissprot:YFJD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFJD_ECOLI octanol swissprot:YFJD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFJD_ECOLI pepcoil swissprot:YFJD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFJD_ECOLI pepdigest swissprot:YFJD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFJD_ECOLI pepinfo swissprot:YFJD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFJD_ECOLI pepnet swissprot:YFJD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFJD_ECOLI pepstats swissprot:YFJD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFJD_ECOLI pepwheel swissprot:YFJD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFJD_ECOLI pepwindow swissprot:YFJD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFJD_ECOLI sigcleave swissprot:YFJD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFJD_ECOLI ## Database ID URL or Descriptions # BioGrid 4259433 59 # COFACTOR ISCR_ECOLI Name=[2Fe-2S] cluster; Xref=ChEBI CHEBI 49601; Evidence={ECO 0000269|PubMed 11742080, ECO 0000269|PubMed 16677314}; Note=Binds 1 [2Fe-2S] cluster; whether or not the Fe-S cluster is necessary for transcriptional regulation depends on the type of IscR-binding sequence. {ECO 0000269|PubMed 11742080, ECO 0000269|PubMed 16677314}; # EcoGene EG13397 iscR # FUNCTION ISCR_ECOLI Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. Transcriptional repressor of the iscRSUA operon, which is involved in the assembly of Fe-S clusters into Fe-S proteins. In its apoform, under conditions of oxidative stress or iron deprivation, it activates the suf operon, which is a second operon involved in the assembly of Fe-S clusters. Represses its own transcription as well as that of toxin rnlA. {ECO 0000269|PubMed 11742080, ECO 0000269|PubMed 16824106, ECO 0000269|PubMed 20421606}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003690 double-stranded DNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IDA:EcoCyc. # GO_function GO:0005506 iron ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0051537 2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-HAMAP. # GO_process GO:0006355 regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # HAMAP MF_01176 HTH_type_IscR # INDUCTION By oxidative stress conditions and iron starvation. {ECO:0000269|PubMed 16677314}. # IntAct P0AGK8 3 # InterPro IPR000944 Tscrpt_reg_Rrf2-type # InterPro IPR010242 TF_HTH_IscR # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR030489 TR_Rrf2-type_CS # KEGG_Brite ko03000 Transcription factors # Organism ISCR_ECOLI Escherichia coli (strain K12) # PATRIC 32120459 VBIEscCol129921_2632 # PDB 4HF0 X-ray; 1.90 A; A/B=1-133 # PDB 4HF1 X-ray; 2.22 A; A/B=1-162 # PDB 4HF2 X-ray; 2.99 A; A/B=1-162 # PIR B65030 B65030 # PROSITE PS01332 HTH_RRF2_1 # PROSITE PS51197 HTH_RRF2_2 # Pfam PF02082 Rrf2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ISCR_ECOLI HTH-type transcriptional regulator IscR # RefSeq NP_417026 NC_000913.3 # RefSeq WP_001241357 NZ_LN832404.1 # SIMILARITY Contains 1 HTH rrf2-type DNA-binding domain. {ECO 0000305}. # SUPFAM SSF46785 SSF46785 # TIGRFAMs TIGR00738 rrf2_super # TIGRFAMs TIGR02010 IscR # eggNOG COG1959 LUCA # eggNOG ENOG4108ZF1 Bacteria BLAST swissprot:ISCR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ISCR_ECOLI BioCyc ECOL316407:JW2515-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2515-MONOMER BioCyc EcoCyc:G7326-MONOMER http://biocyc.org/getid?id=EcoCyc:G7326-MONOMER COG COG1959 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1959 DIP DIP-47974N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47974N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.251550898 http://dx.doi.org/10.1073/pnas.251550898 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1365-2958.2006.05160.x http://dx.doi.org/10.1111/j.1365-2958.2006.05160.x DOI 10.1111/j.1365-2958.2006.05220.x http://dx.doi.org/10.1111/j.1365-2958.2006.05220.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1534/genetics.110.114462 http://dx.doi.org/10.1534/genetics.110.114462 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3178 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3178 EcoGene EG13397 http://www.ecogene.org/geneInfo.php?eg_id=EG13397 EnsemblBacteria AAC75584 http://www.ensemblgenomes.org/id/AAC75584 EnsemblBacteria AAC75584 http://www.ensemblgenomes.org/id/AAC75584 EnsemblBacteria BAA16425 http://www.ensemblgenomes.org/id/BAA16425 EnsemblBacteria BAA16425 http://www.ensemblgenomes.org/id/BAA16425 EnsemblBacteria BAA16425 http://www.ensemblgenomes.org/id/BAA16425 EnsemblBacteria b2531 http://www.ensemblgenomes.org/id/b2531 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003690 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003690 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0051537 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051537 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 945279 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945279 HAMAP MF_01176 http://hamap.expasy.org/unirule/MF_01176 HOGENOM HOG000249812 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000249812&db=HOGENOM6 InParanoid P0AGK8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGK8 IntAct P0AGK8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AGK8* InterPro IPR000944 http://www.ebi.ac.uk/interpro/entry/IPR000944 InterPro IPR010242 http://www.ebi.ac.uk/interpro/entry/IPR010242 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR030489 http://www.ebi.ac.uk/interpro/entry/IPR030489 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW2515 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2515 KEGG_Gene eco:b2531 http://www.genome.jp/dbget-bin/www_bget?eco:b2531 KEGG_Orthology KO:K13643 http://www.genome.jp/dbget-bin/www_bget?KO:K13643 OMA MTHDLWS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MTHDLWS PDB 4HF0 http://www.ebi.ac.uk/pdbe-srv/view/entry/4HF0 PDB 4HF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4HF1 PDB 4HF2 http://www.ebi.ac.uk/pdbe-srv/view/entry/4HF2 PDBsum 4HF0 http://www.ebi.ac.uk/pdbsum/4HF0 PDBsum 4HF1 http://www.ebi.ac.uk/pdbsum/4HF1 PDBsum 4HF2 http://www.ebi.ac.uk/pdbsum/4HF2 PROSITE PS01332 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01332 PROSITE PS51197 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51197 PSORT swissprot:ISCR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ISCR_ECOLI PSORT-B swissprot:ISCR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ISCR_ECOLI PSORT2 swissprot:ISCR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ISCR_ECOLI Pfam PF02082 http://pfam.xfam.org/family/PF02082 Phobius swissprot:ISCR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ISCR_ECOLI PhylomeDB P0AGK8 http://phylomedb.org/?seqid=P0AGK8 ProteinModelPortal P0AGK8 http://www.proteinmodelportal.org/query/uniprot/P0AGK8 PubMed 11742080 http://www.ncbi.nlm.nih.gov/pubmed/11742080 PubMed 16677314 http://www.ncbi.nlm.nih.gov/pubmed/16677314 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16824106 http://www.ncbi.nlm.nih.gov/pubmed/16824106 PubMed 20421606 http://www.ncbi.nlm.nih.gov/pubmed/20421606 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417026 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417026 RefSeq WP_001241357 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001241357 SMR P0AGK8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AGK8 STRING 511145.b2531 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2531&targetmode=cogs STRING COG1959 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1959&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 TIGRFAMs TIGR00738 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00738 TIGRFAMs TIGR02010 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02010 UniProtKB ISCR_ECOLI http://www.uniprot.org/uniprot/ISCR_ECOLI UniProtKB-AC P0AGK8 http://www.uniprot.org/uniprot/P0AGK8 charge swissprot:ISCR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ISCR_ECOLI eggNOG COG1959 http://eggnogapi.embl.de/nog_data/html/tree/COG1959 eggNOG ENOG4108ZF1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZF1 epestfind swissprot:ISCR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ISCR_ECOLI garnier swissprot:ISCR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ISCR_ECOLI helixturnhelix swissprot:ISCR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ISCR_ECOLI hmoment swissprot:ISCR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ISCR_ECOLI iep swissprot:ISCR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ISCR_ECOLI inforesidue swissprot:ISCR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ISCR_ECOLI octanol swissprot:ISCR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ISCR_ECOLI pepcoil swissprot:ISCR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ISCR_ECOLI pepdigest swissprot:ISCR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ISCR_ECOLI pepinfo swissprot:ISCR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ISCR_ECOLI pepnet swissprot:ISCR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ISCR_ECOLI pepstats swissprot:ISCR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ISCR_ECOLI pepwheel swissprot:ISCR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ISCR_ECOLI pepwindow swissprot:ISCR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ISCR_ECOLI sigcleave swissprot:ISCR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ISCR_ECOLI ## Database ID URL or Descriptions # AltName GNTK_ECOLI Gluconate kinase 2 # CATALYTIC ACTIVITY GNTK_ECOLI ATP + D-gluconate = ADP + 6-phospho-D- gluconate. # CDD cd02021 GntK # EcoGene EG12629 gntK # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0046316 gluconokinase activity; IDA:EcoCyc. # GO_process GO:0046177 D-gluconate catabolic process; IEA:UniProtKB-UniPathway. # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.300 -; 1. # IntAct P46859 2 # InterPro IPR006001 Therm_gnt_kin # InterPro IPR027417 P-loop_NTPase # InterPro IPR031322 Shikimate/glucono_kinase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00030 Pentose phosphate pathway # Organism GNTK_ECOLI Escherichia coli (strain K12) # PATHWAY GNTK_ECOLI Carbohydrate acid metabolism; D-gluconate degradation. # PATRIC 32122312 VBIEscCol129921_3533 # PDB 1KNQ X-ray; 2.00 A; A/B=1-175 # PDB 1KO1 X-ray; 2.09 A; A/B=1-175 # PDB 1KO4 X-ray; 2.50 A; A/B=1-175 # PDB 1KO5 X-ray; 2.28 A; A/B=1-175 # PDB 1KO8 X-ray; 2.40 A; A/B=1-175 # PDB 1KOF X-ray; 2.80 A; A/B=1-175 # Pfam PF01202 SKI # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GNTK_ECOLI Thermoresistant gluconokinase # RefSeq NP_417894 NC_000913.3 # RefSeq WP_000108330 NZ_LN832404.1 # SIMILARITY Belongs to the gluconokinase GntK/GntV family. {ECO 0000305}. # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR01313 therm_gnt_kin # eggNOG COG3265 LUCA # eggNOG ENOG4108Z67 Bacteria BLAST swissprot:GNTK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GNTK_ECOLI BioCyc ECOL316407:JW3400-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3400-MONOMER BioCyc EcoCyc:GLUCONOKINII-MONOMER http://biocyc.org/getid?id=EcoCyc:GLUCONOKINII-MONOMER BioCyc MetaCyc:GLUCONOKINII-MONOMER http://biocyc.org/getid?id=MetaCyc:GLUCONOKINII-MONOMER COG COG3265 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3265 DIP DIP-9820N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9820N DOI 10.1006/jmbi.1996.0913 http://dx.doi.org/10.1006/jmbi.1996.0913 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1107/S090744490100871X http://dx.doi.org/10.1107/S090744490100871X DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.12 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.12 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D84362 http://www.ebi.ac.uk/ena/data/view/D84362 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 2.7.1.12 http://enzyme.expasy.org/EC/2.7.1.12 EchoBASE EB2513 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2513 EcoGene EG12629 http://www.ecogene.org/geneInfo.php?eg_id=EG12629 EnsemblBacteria AAC76462 http://www.ensemblgenomes.org/id/AAC76462 EnsemblBacteria AAC76462 http://www.ensemblgenomes.org/id/AAC76462 EnsemblBacteria BAE77856 http://www.ensemblgenomes.org/id/BAE77856 EnsemblBacteria BAE77856 http://www.ensemblgenomes.org/id/BAE77856 EnsemblBacteria BAE77856 http://www.ensemblgenomes.org/id/BAE77856 EnsemblBacteria b3437 http://www.ensemblgenomes.org/id/b3437 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0046316 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046316 GO_process GO:0046177 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046177 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947937 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947937 HOGENOM HOG000032567 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000032567&db=HOGENOM6 InParanoid P46859 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P46859 IntAct P46859 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P46859* IntEnz 2.7.1.12 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.12 InterPro IPR006001 http://www.ebi.ac.uk/interpro/entry/IPR006001 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR031322 http://www.ebi.ac.uk/interpro/entry/IPR031322 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3400 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3400 KEGG_Gene eco:b3437 http://www.genome.jp/dbget-bin/www_bget?eco:b3437 KEGG_Orthology KO:K00851 http://www.genome.jp/dbget-bin/www_bget?KO:K00851 KEGG_Pathway ko00030 http://www.genome.jp/kegg-bin/show_pathway?ko00030 KEGG_Reaction rn:R01737 http://www.genome.jp/dbget-bin/www_bget?rn:R01737 OMA VPYAEGD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VPYAEGD PDB 1KNQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1KNQ PDB 1KO1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1KO1 PDB 1KO4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1KO4 PDB 1KO5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1KO5 PDB 1KO8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1KO8 PDB 1KOF http://www.ebi.ac.uk/pdbe-srv/view/entry/1KOF PDBsum 1KNQ http://www.ebi.ac.uk/pdbsum/1KNQ PDBsum 1KO1 http://www.ebi.ac.uk/pdbsum/1KO1 PDBsum 1KO4 http://www.ebi.ac.uk/pdbsum/1KO4 PDBsum 1KO5 http://www.ebi.ac.uk/pdbsum/1KO5 PDBsum 1KO8 http://www.ebi.ac.uk/pdbsum/1KO8 PDBsum 1KOF http://www.ebi.ac.uk/pdbsum/1KOF PSORT swissprot:GNTK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GNTK_ECOLI PSORT-B swissprot:GNTK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GNTK_ECOLI PSORT2 swissprot:GNTK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GNTK_ECOLI Pfam PF01202 http://pfam.xfam.org/family/PF01202 Phobius swissprot:GNTK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GNTK_ECOLI PhylomeDB P46859 http://phylomedb.org/?seqid=P46859 ProteinModelPortal P46859 http://www.proteinmodelportal.org/query/uniprot/P46859 PubMed 11468405 http://www.ncbi.nlm.nih.gov/pubmed/11468405 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8655507 http://www.ncbi.nlm.nih.gov/pubmed/8655507 PubMed 9135111 http://www.ncbi.nlm.nih.gov/pubmed/9135111 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417894 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417894 RefSeq WP_000108330 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000108330 SMR P46859 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P46859 STRING 511145.b3437 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3437&targetmode=cogs STRING COG3265 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3265&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR01313 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01313 UniProtKB GNTK_ECOLI http://www.uniprot.org/uniprot/GNTK_ECOLI UniProtKB-AC P46859 http://www.uniprot.org/uniprot/P46859 charge swissprot:GNTK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GNTK_ECOLI eggNOG COG3265 http://eggnogapi.embl.de/nog_data/html/tree/COG3265 eggNOG ENOG4108Z67 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Z67 epestfind swissprot:GNTK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GNTK_ECOLI garnier swissprot:GNTK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GNTK_ECOLI helixturnhelix swissprot:GNTK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GNTK_ECOLI hmoment swissprot:GNTK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GNTK_ECOLI iep swissprot:GNTK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GNTK_ECOLI inforesidue swissprot:GNTK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GNTK_ECOLI octanol swissprot:GNTK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GNTK_ECOLI pepcoil swissprot:GNTK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GNTK_ECOLI pepdigest swissprot:GNTK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GNTK_ECOLI pepinfo swissprot:GNTK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GNTK_ECOLI pepnet swissprot:GNTK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GNTK_ECOLI pepstats swissprot:GNTK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GNTK_ECOLI pepwheel swissprot:GNTK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GNTK_ECOLI pepwindow swissprot:GNTK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GNTK_ECOLI sigcleave swissprot:GNTK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GNTK_ECOLI ## Database ID URL or Descriptions # BioGrid 4260920 8 # EcoGene EG14188 eutD # GO_function GO:0008959 phosphate acetyltransferase activity; IDA:EcoCyc. # GO_process GO:0009408 response to heat; IMP:EcoCyc. # GO_process GO:0046336 ethanolamine catabolic process; IEA:UniProtKB-UniPathway. # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # IntAct P77218 8 # InterPro IPR002505 PTA_PTB # InterPro IPR004614 P_AcTrfase # InterPro IPR012147 P_Ac_Bu_trans # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko00620 Pyruvate metabolism # Organism EUTD_ECOLI Escherichia coli (strain K12) # PATHWAY EUTD_ECOLI Amine and polyamine degradation; ethanolamine degradation. # PATRIC 32120299 VBIEscCol129921_2552 # PDB 1VMI X-ray; 2.32 A; A=2-338 # PIR A65021 A65021 # PIRSF PIRSF000428 P_Ac_trans # Pfam PF01515 PTA_PTB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EUTD_ECOLI Ethanolamine utilization protein EutD # RefSeq NP_416953 NC_000913.3 # RefSeq WP_000582977 NZ_LN832404.1 # SIMILARITY Belongs to the phosphate acetyltransferase and butyryltransferase family. {ECO 0000305}. # TIGRFAMs TIGR00651 pta # eggNOG COG0280 LUCA # eggNOG ENOG4107WUY Bacteria BLAST swissprot:EUTD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EUTD_ECOLI BioCyc ECOL316407:JW2442-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2442-MONOMER BioCyc EcoCyc:G7288-MONOMER http://biocyc.org/getid?id=EcoCyc:G7288-MONOMER BioCyc MetaCyc:G7288-MONOMER http://biocyc.org/getid?id=MetaCyc:G7288-MONOMER COG COG0280 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0280 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3940 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3940 EcoGene EG14188 http://www.ecogene.org/geneInfo.php?eg_id=EG14188 EnsemblBacteria AAC75511 http://www.ensemblgenomes.org/id/AAC75511 EnsemblBacteria AAC75511 http://www.ensemblgenomes.org/id/AAC75511 EnsemblBacteria BAA16336 http://www.ensemblgenomes.org/id/BAA16336 EnsemblBacteria BAA16336 http://www.ensemblgenomes.org/id/BAA16336 EnsemblBacteria BAA16336 http://www.ensemblgenomes.org/id/BAA16336 EnsemblBacteria b2458 http://www.ensemblgenomes.org/id/b2458 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008959 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008959 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GO_process GO:0046336 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046336 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 946940 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946940 HOGENOM HOG000053796 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000053796&db=HOGENOM6 InParanoid P77218 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77218 IntAct P77218 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77218* InterPro IPR002505 http://www.ebi.ac.uk/interpro/entry/IPR002505 InterPro IPR004614 http://www.ebi.ac.uk/interpro/entry/IPR004614 InterPro IPR012147 http://www.ebi.ac.uk/interpro/entry/IPR012147 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW2442 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2442 KEGG_Gene eco:b2458 http://www.genome.jp/dbget-bin/www_bget?eco:b2458 KEGG_Orthology KO:K04020 http://www.genome.jp/dbget-bin/www_bget?KO:K04020 KEGG_Pathway ko00620 http://www.genome.jp/kegg-bin/show_pathway?ko00620 KEGG_Reaction rn:R00230 http://www.genome.jp/dbget-bin/www_bget?rn:R00230 OMA VVPNCEY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VVPNCEY PDB 1VMI http://www.ebi.ac.uk/pdbe-srv/view/entry/1VMI PDBsum 1VMI http://www.ebi.ac.uk/pdbsum/1VMI PSORT swissprot:EUTD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EUTD_ECOLI PSORT-B swissprot:EUTD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EUTD_ECOLI PSORT2 swissprot:EUTD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EUTD_ECOLI Pfam PF01515 http://pfam.xfam.org/family/PF01515 Phobius swissprot:EUTD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EUTD_ECOLI PhylomeDB P77218 http://phylomedb.org/?seqid=P77218 ProteinModelPortal P77218 http://www.proteinmodelportal.org/query/uniprot/P77218 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416953 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416953 RefSeq WP_000582977 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000582977 SMR P77218 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77218 STRING 511145.b2458 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2458&targetmode=cogs STRING COG0280 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0280&targetmode=cogs TIGRFAMs TIGR00651 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00651 UniProtKB EUTD_ECOLI http://www.uniprot.org/uniprot/EUTD_ECOLI UniProtKB-AC P77218 http://www.uniprot.org/uniprot/P77218 charge swissprot:EUTD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EUTD_ECOLI eggNOG COG0280 http://eggnogapi.embl.de/nog_data/html/tree/COG0280 eggNOG ENOG4107WUY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107WUY epestfind swissprot:EUTD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EUTD_ECOLI garnier swissprot:EUTD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EUTD_ECOLI helixturnhelix swissprot:EUTD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EUTD_ECOLI hmoment swissprot:EUTD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EUTD_ECOLI iep swissprot:EUTD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EUTD_ECOLI inforesidue swissprot:EUTD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EUTD_ECOLI octanol swissprot:EUTD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EUTD_ECOLI pepcoil swissprot:EUTD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EUTD_ECOLI pepdigest swissprot:EUTD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EUTD_ECOLI pepinfo swissprot:EUTD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EUTD_ECOLI pepnet swissprot:EUTD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EUTD_ECOLI pepstats swissprot:EUTD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EUTD_ECOLI pepwheel swissprot:EUTD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EUTD_ECOLI pepwindow swissprot:EUTD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EUTD_ECOLI sigcleave swissprot:EUTD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EUTD_ECOLI ## Database ID URL or Descriptions # BioGrid 4262349 21 # EcoGene EG13165 yqgC # IntAct P64570 4 # InterPro IPR020102 Uncharacterised_YqgC # Organism YQGC_ECOLI Escherichia coli (strain K12) # PIR C65079 C65079 # ProDom PD056256 Uncharacterised_YqgC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQGC_ECOLI Uncharacterized protein YqgC # RefSeq NP_417415 NC_000913.3 # RefSeq WP_001303650 NZ_LN832404.1 BLAST swissprot:YQGC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQGC_ECOLI BioCyc ECOL316407:JW2907-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2907-MONOMER BioCyc EcoCyc:G7522-MONOMER http://biocyc.org/getid?id=EcoCyc:G7522-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2957 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2957 EcoGene EG13165 http://www.ecogene.org/geneInfo.php?eg_id=EG13165 EnsemblBacteria AAC75977 http://www.ensemblgenomes.org/id/AAC75977 EnsemblBacteria AAC75977 http://www.ensemblgenomes.org/id/AAC75977 EnsemblBacteria BAE77003 http://www.ensemblgenomes.org/id/BAE77003 EnsemblBacteria BAE77003 http://www.ensemblgenomes.org/id/BAE77003 EnsemblBacteria BAE77003 http://www.ensemblgenomes.org/id/BAE77003 EnsemblBacteria b2940 http://www.ensemblgenomes.org/id/b2940 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945052 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945052 HOGENOM HOG000054892 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000054892&db=HOGENOM6 IntAct P64570 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P64570* InterPro IPR020102 http://www.ebi.ac.uk/interpro/entry/IPR020102 KEGG_Gene ecj:JW2907 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2907 KEGG_Gene eco:b2940 http://www.genome.jp/dbget-bin/www_bget?eco:b2940 OMA RIFTRSV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RIFTRSV PSORT swissprot:YQGC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQGC_ECOLI PSORT-B swissprot:YQGC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQGC_ECOLI PSORT2 swissprot:YQGC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQGC_ECOLI Phobius swissprot:YQGC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQGC_ECOLI ProteinModelPortal P64570 http://www.proteinmodelportal.org/query/uniprot/P64570 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417415 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417415 RefSeq WP_001303650 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001303650 STRING 511145.b2940 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2940&targetmode=cogs UniProtKB YQGC_ECOLI http://www.uniprot.org/uniprot/YQGC_ECOLI UniProtKB-AC P64570 http://www.uniprot.org/uniprot/P64570 charge swissprot:YQGC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQGC_ECOLI epestfind swissprot:YQGC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQGC_ECOLI garnier swissprot:YQGC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQGC_ECOLI helixturnhelix swissprot:YQGC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQGC_ECOLI hmoment swissprot:YQGC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQGC_ECOLI iep swissprot:YQGC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQGC_ECOLI inforesidue swissprot:YQGC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQGC_ECOLI octanol swissprot:YQGC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQGC_ECOLI pepcoil swissprot:YQGC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQGC_ECOLI pepdigest swissprot:YQGC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQGC_ECOLI pepinfo swissprot:YQGC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQGC_ECOLI pepnet swissprot:YQGC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQGC_ECOLI pepstats swissprot:YQGC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQGC_ECOLI pepwheel swissprot:YQGC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQGC_ECOLI pepwindow swissprot:YQGC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQGC_ECOLI sigcleave swissprot:YQGC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQGC_ECOLI ## Database ID URL or Descriptions # AltName FSAB_ECOLI Fructose-6-phosphate aldolase B # BIOPHYSICOCHEMICAL PROPERTIES FSAB_ECOLI Kinetic parameters KM=27 mM for dihydroxyacetone {ECO 0000269|Ref.6}; KM=15 mM for hydroxyacetone {ECO 0000269|Ref.6}; KM=0.28 mM for glycolaldehyde (as donor substrate in the self- aldol addition of glycolaldehyde) {ECO 0000269|Ref.6}; KM=65 mM for glycolaldehyde (as acceptor substrate in the self- aldol addition of glycolaldehyde) {ECO 0000269|Ref.6}; KM=0.65 mM for D,L-glyceraldehyde 3-phosphate {ECO 0000269|Ref.6}; KM=6.70 mM for D-fructose 6-phosphate {ECO 0000269|Ref.6}; KM=210 mM for D-fructose {ECO 0000269|Ref.6}; KM=271 mM for D-sorbose {ECO 0000269|Ref.6}; Note=Catalytic efficiency is 28-fold higher using glyceraldehyde 3-phosphate as acceptor substrate and hydroxyacetone as donor substrate than with dihydroxyacetone as the donor.; pH dependence Optimum pH is 8.5 for the retroaldol activity on F6P. {ECO 0000269|Ref.6}; Temperature dependence Is not thermally stable at temperatures higher than 60 degrees Celsius. Is less thermostable than the isozyme FsaA. {ECO 0000269|Ref.6}; # BioGrid 4263139 10 # CATALYTIC ACTIVITY D-fructose 6-phosphate = glycerone + D- glyceraldehyde 3-phosphate. {ECO:0000269|PubMed 11120740, ECO:0000269|Ref.6}. # CDD cd00956 Transaldolase_FSA # EcoGene EG11905 fsaB # FUNCTION FSAB_ECOLI Catalyzes the reversible formation of fructose 6- phosphate from dihydroxyacetone and D-glyceraldehyde 3-phosphate via an aldolization reaction. Can utilize hydroxyacetone as an alternative donor substrate. Is also able to catalyze the direct self-aldol addition of glycolaldehyde. Is less catalytically efficient than the isozyme FsaA. Does not display transaldolase activity. {ECO 0000269|PubMed 11120740, ECO 0000269|Ref.6}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0097023 fructose 6-phosphate aldolase activity; IDA:EcoCyc. # GO_process GO:0006000 fructose metabolic process; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.70 -; 1. # HAMAP MF_00496 F6P_aldolase # IntAct P32669 5 # InterPro IPR001585 TAL/FSA # InterPro IPR004731 Transaldolase_3B/F6P_aldolase # InterPro IPR013785 Aldolase_TIM # InterPro IPR018225 Transaldolase_AS # InterPro IPR023001 F6P_aldolase # InterPro IPR033919 TSA/FSA_arc/bac # KEGG_Brite ko01000 Enzymes # Organism FSAB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10683 PTHR10683 # PATRIC 32123415 VBIEscCol129921_4068 # PIR E65201 E65201 # PROSITE PS00958 TRANSALDOLASE_2 # PROSITE PS01054 TRANSALDOLASE_1 # Pfam PF00923 TAL_FSA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FSAB_ECOLI Fructose-6-phosphate aldolase 2 # RefSeq NP_418381 NC_000913.3 # RefSeq WP_000424840 NZ_LN832404.1 # SIMILARITY Belongs to the transaldolase family. Type 3A subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION FSAB_ECOLI Cytoplasm {ECO 0000250}. # SUBUNIT Homodecamer. {ECO 0000269|Ref.6}. # TIGRFAMs TIGR00875 fsa_talC_mipB # eggNOG COG0176 LUCA # eggNOG ENOG4107T9Z Bacteria BLAST swissprot:FSAB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FSAB_ECOLI BioCyc ECOL316407:JW3918-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3918-MONOMER BioCyc EcoCyc:EG11905-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11905-MONOMER BioCyc MetaCyc:EG11905-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11905-MONOMER COG COG0176 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0176 DOI 10.1016/j.molcatb.2012.02.010 http://dx.doi.org/10.1016/j.molcatb.2012.02.010 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M008061200 http://dx.doi.org/10.1074/jbc.M008061200 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1099/13500872-141-4-961 http://dx.doi.org/10.1099/13500872-141-4-961 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.1.2.- http://www.genome.jp/dbget-bin/www_bget?EC:4.1.2.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 4.1.2.- http://enzyme.expasy.org/EC/4.1.2.- EchoBASE EB1850 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1850 EcoGene EG11905 http://www.ecogene.org/geneInfo.php?eg_id=EG11905 EnsemblBacteria AAC76928 http://www.ensemblgenomes.org/id/AAC76928 EnsemblBacteria AAC76928 http://www.ensemblgenomes.org/id/AAC76928 EnsemblBacteria BAE77364 http://www.ensemblgenomes.org/id/BAE77364 EnsemblBacteria BAE77364 http://www.ensemblgenomes.org/id/BAE77364 EnsemblBacteria BAE77364 http://www.ensemblgenomes.org/id/BAE77364 EnsemblBacteria b3946 http://www.ensemblgenomes.org/id/b3946 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0097023 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097023 GO_process GO:0006000 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006000 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 948439 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948439 HAMAP MF_00496 http://hamap.expasy.org/unirule/MF_00496 HOGENOM HOG000226075 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000226075&db=HOGENOM6 InParanoid P32669 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32669 IntAct P32669 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32669* IntEnz 4.1.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.2 InterPro IPR001585 http://www.ebi.ac.uk/interpro/entry/IPR001585 InterPro IPR004731 http://www.ebi.ac.uk/interpro/entry/IPR004731 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR018225 http://www.ebi.ac.uk/interpro/entry/IPR018225 InterPro IPR023001 http://www.ebi.ac.uk/interpro/entry/IPR023001 InterPro IPR033919 http://www.ebi.ac.uk/interpro/entry/IPR033919 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3918 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3918 KEGG_Gene eco:b3946 http://www.genome.jp/dbget-bin/www_bget?eco:b3946 KEGG_Orthology KO:K08314 http://www.genome.jp/dbget-bin/www_bget?KO:K08314 OMA QMLGTPA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QMLGTPA PANTHER PTHR10683 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10683 PROSITE PS00958 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00958 PROSITE PS01054 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01054 PSORT swissprot:FSAB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FSAB_ECOLI PSORT-B swissprot:FSAB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FSAB_ECOLI PSORT2 swissprot:FSAB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FSAB_ECOLI Pfam PF00923 http://pfam.xfam.org/family/PF00923 Phobius swissprot:FSAB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FSAB_ECOLI PhylomeDB P32669 http://phylomedb.org/?seqid=P32669 ProteinModelPortal P32669 http://www.proteinmodelportal.org/query/uniprot/P32669 PubMed 11120740 http://www.ncbi.nlm.nih.gov/pubmed/11120740 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7773398 http://www.ncbi.nlm.nih.gov/pubmed/7773398 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418381 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418381 RefSeq WP_000424840 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000424840 SMR P32669 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32669 STRING 511145.b3946 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3946&targetmode=cogs STRING COG0176 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0176&targetmode=cogs TIGRFAMs TIGR00875 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00875 UniProtKB FSAB_ECOLI http://www.uniprot.org/uniprot/FSAB_ECOLI UniProtKB-AC P32669 http://www.uniprot.org/uniprot/P32669 charge swissprot:FSAB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FSAB_ECOLI eggNOG COG0176 http://eggnogapi.embl.de/nog_data/html/tree/COG0176 eggNOG ENOG4107T9Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107T9Z epestfind swissprot:FSAB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FSAB_ECOLI garnier swissprot:FSAB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FSAB_ECOLI helixturnhelix swissprot:FSAB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FSAB_ECOLI hmoment swissprot:FSAB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FSAB_ECOLI iep swissprot:FSAB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FSAB_ECOLI inforesidue swissprot:FSAB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FSAB_ECOLI octanol swissprot:FSAB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FSAB_ECOLI pepcoil swissprot:FSAB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FSAB_ECOLI pepdigest swissprot:FSAB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FSAB_ECOLI pepinfo swissprot:FSAB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FSAB_ECOLI pepnet swissprot:FSAB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FSAB_ECOLI pepstats swissprot:FSAB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FSAB_ECOLI pepwheel swissprot:FSAB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FSAB_ECOLI pepwindow swissprot:FSAB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FSAB_ECOLI sigcleave swissprot:FSAB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FSAB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260493 174 # CDD cd00207 fer2 # COFACTOR YFAE_ECOLI Name=[2Fe-2S] cluster; Xref=ChEBI CHEBI 49601; Evidence={ECO 0000305}; Note=Binds 1 [2Fe-2S] cluster. {ECO 0000305}; # EcoGene EG12360 yfaE # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_function GO:0009055 electron carrier activity; IDA:EcoliWiki. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051537 2 iron, 2 sulfur cluster binding; IDA:EcoCyc. # GO_process GO:0006124 ferredoxin metabolic process; IDA:EcoliWiki. # GO_process GO:0055114 oxidation-reduction process; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # Gene3D 3.10.20.30 -; 1. # InterPro IPR001041 2Fe-2S_ferredoxin-type # InterPro IPR006058 2Fe2S_fd_BS # InterPro IPR012675 Beta-grasp_dom # Organism YFAE_ECOLI Escherichia coli (strain K12) # PATRIC 32119831 VBIEscCol129921_2325 # PIR B64994 B64994 # PROSITE PS00197 2FE2S_FER_1 # PROSITE PS51085 2FE2S_FER_2 # Pfam PF00111 Fer2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFAE_ECOLI Uncharacterized ferredoxin-like protein YfaE # RefSeq NP_416739 NC_000913.3 # RefSeq WP_000135040 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=K02672; Type=Frameshift; Positions=28; Evidence={ECO 0000305}; # SIMILARITY Contains 1 2Fe-2S ferredoxin-type domain. {ECO:0000255|PROSITE-ProRule PRU00465}. # SUPFAM SSF54292 SSF54292 # eggNOG COG0633 LUCA # eggNOG ENOG4105XPH Bacteria BLAST swissprot:YFAE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFAE_ECOLI BioCyc ECOL316407:JW2230-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2230-MONOMER BioCyc EcoCyc:EG12360-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12360-MONOMER COG COG0633 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0633 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.81.14.4294 http://dx.doi.org/10.1073/pnas.81.14.4294 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K02672 http://www.ebi.ac.uk/ena/data/view/K02672 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2263 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2263 EcoGene EG12360 http://www.ecogene.org/geneInfo.php?eg_id=EG12360 EnsemblBacteria AAC75296 http://www.ensemblgenomes.org/id/AAC75296 EnsemblBacteria AAC75296 http://www.ensemblgenomes.org/id/AAC75296 EnsemblBacteria BAA16055 http://www.ensemblgenomes.org/id/BAA16055 EnsemblBacteria BAA16055 http://www.ensemblgenomes.org/id/BAA16055 EnsemblBacteria BAA16055 http://www.ensemblgenomes.org/id/BAA16055 EnsemblBacteria b2236 http://www.ensemblgenomes.org/id/b2236 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051537 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051537 GO_process GO:0006124 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006124 GO_process GO:0055114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.10.20.30 http://www.cathdb.info/version/latest/superfamily/3.10.20.30 GeneID 946729 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946729 HOGENOM HOG000217153 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000217153&db=HOGENOM6 InParanoid P0ABW3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABW3 InterPro IPR001041 http://www.ebi.ac.uk/interpro/entry/IPR001041 InterPro IPR006058 http://www.ebi.ac.uk/interpro/entry/IPR006058 InterPro IPR012675 http://www.ebi.ac.uk/interpro/entry/IPR012675 KEGG_Gene ecj:JW2230 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2230 KEGG_Gene eco:b2236 http://www.genome.jp/dbget-bin/www_bget?eco:b2236 KEGG_Orthology KO:K11107 http://www.genome.jp/dbget-bin/www_bget?KO:K11107 OMA YCGSCRC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YCGSCRC PROSITE PS00197 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00197 PROSITE PS51085 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51085 PSORT swissprot:YFAE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFAE_ECOLI PSORT-B swissprot:YFAE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFAE_ECOLI PSORT2 swissprot:YFAE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFAE_ECOLI Pfam PF00111 http://pfam.xfam.org/family/PF00111 Phobius swissprot:YFAE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFAE_ECOLI ProteinModelPortal P0ABW3 http://www.proteinmodelportal.org/query/uniprot/P0ABW3 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6087316 http://www.ncbi.nlm.nih.gov/pubmed/6087316 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416739 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416739 RefSeq WP_000135040 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000135040 SMR P0ABW3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABW3 STRING 511145.b2236 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2236&targetmode=cogs STRING COG0633 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0633&targetmode=cogs SUPFAM SSF54292 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54292 UniProtKB YFAE_ECOLI http://www.uniprot.org/uniprot/YFAE_ECOLI UniProtKB-AC P0ABW3 http://www.uniprot.org/uniprot/P0ABW3 charge swissprot:YFAE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFAE_ECOLI eggNOG COG0633 http://eggnogapi.embl.de/nog_data/html/tree/COG0633 eggNOG ENOG4105XPH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105XPH epestfind swissprot:YFAE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFAE_ECOLI garnier swissprot:YFAE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFAE_ECOLI helixturnhelix swissprot:YFAE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFAE_ECOLI hmoment swissprot:YFAE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFAE_ECOLI iep swissprot:YFAE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFAE_ECOLI inforesidue swissprot:YFAE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFAE_ECOLI octanol swissprot:YFAE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFAE_ECOLI pepcoil swissprot:YFAE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFAE_ECOLI pepdigest swissprot:YFAE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFAE_ECOLI pepinfo swissprot:YFAE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFAE_ECOLI pepnet swissprot:YFAE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFAE_ECOLI pepstats swissprot:YFAE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFAE_ECOLI pepwheel swissprot:YFAE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFAE_ECOLI pepwindow swissprot:YFAE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFAE_ECOLI sigcleave swissprot:YFAE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFAE_ECOLI ## Database ID URL or Descriptions # AltName SDHL_ECOLI L-serine deaminase 1 # BRENDA 4.3.1.17 2026 # BioGrid 4260949 2 # CATALYTIC ACTIVITY SDHL_ECOLI L-serine = pyruvate + NH(3). # COFACTOR SDHL_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000305}; Note=Binds 1 [4Fe-4S] cluster. {ECO 0000305}; # EcoGene EG10930 sdaA # FUNCTION SDHL_ECOLI Deaminates also threonine, particularly when it is present in high concentration. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003941 L-serine ammonia-lyase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0006094 gluconeogenesis; IEA:UniProtKB-UniPathway. # GO_process GO:0006565 L-serine catabolic process; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.30.1330.90 -; 1. # INDUCTION SDHL_ECOLI It is made aerobically and anaerobically, in minimal medium. # IntAct P16095 3 # InterPro IPR004644 Fe-S_L-Ser_mono # InterPro IPR005130 Ser_deHydtase-like_asu # InterPro IPR005131 Ser_deHydtase_bsu # InterPro IPR029009 ASB_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00260 Glycine, serine and threonine metabolism # KEGG_Pathway ko00270 Cysteine and methionine metabolism # Organism SDHL_ECOLI Escherichia coli (strain K12) # PATHWAY SDHL_ECOLI Carbohydrate biosynthesis; gluconeogenesis. # PATRIC 32118947 VBIEscCol129921_1891 # PIR F64942 DWECL # PTM SDHL_ECOLI Activated by post-translational modification by a system involving at least three gene products. Activation is mimicked in vitro by iron and dithiothreitol. There is considerable evidence for a free-radical activation mechanism. # Pfam PF03313 SDH_alpha # Pfam PF03315 SDH_beta # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SDHL_ECOLI L-serine dehydratase 1 # RefSeq NP_416328 NC_000913.3 # RefSeq WP_000624298 NZ_LN832404.1 # SIMILARITY Belongs to the iron-sulfur dependent L-serine dehydratase family. {ECO 0000305}. # SUPFAM SSF143548 SSF143548 # TIGRFAMs TIGR00720 sda_mono # eggNOG COG1760 LUCA # eggNOG ENOG4105EJQ Bacteria BLAST swissprot:SDHL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SDHL_ECOLI BioCyc ECOL316407:JW1803-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1803-MONOMER BioCyc EcoCyc:LSERINEDEAM1-MONOMER http://biocyc.org/getid?id=EcoCyc:LSERINEDEAM1-MONOMER BioCyc MetaCyc:LSERINEDEAM1-MONOMER http://biocyc.org/getid?id=MetaCyc:LSERINEDEAM1-MONOMER COG COG1760 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1760 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1111/j.1432-1033.1993.tb17578.x http://dx.doi.org/10.1111/j.1432-1033.1993.tb17578.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.3.1.17 http://www.genome.jp/dbget-bin/www_bget?EC:4.3.1.17 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M28695 http://www.ebi.ac.uk/ena/data/view/M28695 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 4.3.1.17 http://enzyme.expasy.org/EC/4.3.1.17 EchoBASE EB0923 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0923 EcoGene EG10930 http://www.ecogene.org/geneInfo.php?eg_id=EG10930 EnsemblBacteria AAC74884 http://www.ensemblgenomes.org/id/AAC74884 EnsemblBacteria AAC74884 http://www.ensemblgenomes.org/id/AAC74884 EnsemblBacteria BAA15621 http://www.ensemblgenomes.org/id/BAA15621 EnsemblBacteria BAA15621 http://www.ensemblgenomes.org/id/BAA15621 EnsemblBacteria BAA15621 http://www.ensemblgenomes.org/id/BAA15621 EnsemblBacteria b1814 http://www.ensemblgenomes.org/id/b1814 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003941 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003941 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0006094 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006094 GO_process GO:0006565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006565 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.30.1330.90 http://www.cathdb.info/version/latest/superfamily/3.30.1330.90 GeneID 946331 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946331 HOGENOM HOG000036732 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000036732&db=HOGENOM6 InParanoid P16095 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P16095 IntAct P16095 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P16095* IntEnz 4.3.1.17 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.3.1.17 InterPro IPR004644 http://www.ebi.ac.uk/interpro/entry/IPR004644 InterPro IPR005130 http://www.ebi.ac.uk/interpro/entry/IPR005130 InterPro IPR005131 http://www.ebi.ac.uk/interpro/entry/IPR005131 InterPro IPR029009 http://www.ebi.ac.uk/interpro/entry/IPR029009 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1803 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1803 KEGG_Gene eco:b1814 http://www.genome.jp/dbget-bin/www_bget?eco:b1814 KEGG_Orthology KO:K01752 http://www.genome.jp/dbget-bin/www_bget?KO:K01752 KEGG_Pathway ko00260 http://www.genome.jp/kegg-bin/show_pathway?ko00260 KEGG_Pathway ko00270 http://www.genome.jp/kegg-bin/show_pathway?ko00270 KEGG_Reaction rn:R00220 http://www.genome.jp/dbget-bin/www_bget?rn:R00220 KEGG_Reaction rn:R00590 http://www.genome.jp/dbget-bin/www_bget?rn:R00590 OMA HLCQATT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HLCQATT PSORT swissprot:SDHL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SDHL_ECOLI PSORT-B swissprot:SDHL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SDHL_ECOLI PSORT2 swissprot:SDHL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SDHL_ECOLI Pfam PF03313 http://pfam.xfam.org/family/PF03313 Pfam PF03315 http://pfam.xfam.org/family/PF03315 Phobius swissprot:SDHL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SDHL_ECOLI PhylomeDB P16095 http://phylomedb.org/?seqid=P16095 ProteinModelPortal P16095 http://www.proteinmodelportal.org/query/uniprot/P16095 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2504697 http://www.ncbi.nlm.nih.gov/pubmed/2504697 PubMed 8436113 http://www.ncbi.nlm.nih.gov/pubmed/8436113 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416328 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416328 RefSeq WP_000624298 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000624298 SMR P16095 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P16095 STRING 511145.b1814 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1814&targetmode=cogs STRING COG1760 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1760&targetmode=cogs SUPFAM SSF143548 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF143548 TIGRFAMs TIGR00720 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00720 UniProtKB SDHL_ECOLI http://www.uniprot.org/uniprot/SDHL_ECOLI UniProtKB-AC P16095 http://www.uniprot.org/uniprot/P16095 charge swissprot:SDHL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SDHL_ECOLI eggNOG COG1760 http://eggnogapi.embl.de/nog_data/html/tree/COG1760 eggNOG ENOG4105EJQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EJQ epestfind swissprot:SDHL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SDHL_ECOLI garnier swissprot:SDHL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SDHL_ECOLI helixturnhelix swissprot:SDHL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SDHL_ECOLI hmoment swissprot:SDHL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SDHL_ECOLI iep swissprot:SDHL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SDHL_ECOLI inforesidue swissprot:SDHL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SDHL_ECOLI octanol swissprot:SDHL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SDHL_ECOLI pepcoil swissprot:SDHL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SDHL_ECOLI pepdigest swissprot:SDHL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SDHL_ECOLI pepinfo swissprot:SDHL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SDHL_ECOLI pepnet swissprot:SDHL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SDHL_ECOLI pepstats swissprot:SDHL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SDHL_ECOLI pepwheel swissprot:SDHL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SDHL_ECOLI pepwindow swissprot:SDHL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SDHL_ECOLI sigcleave swissprot:SDHL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SDHL_ECOLI ## Database ID URL or Descriptions # BioGrid 4262470 17 # EcoGene EG12899 yheO # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # InterPro IPR013559 YheO # Organism YHEO_ECOLI Escherichia coli (strain K12) # PATRIC 32122124 VBIEscCol129921_3439 # Pfam PF08348 PAS_6 # ProDom PD037769 YheO # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHEO_ECOLI Uncharacterized protein YheO # RefSeq NP_417805 NC_000913.3 # RefSeq WP_000091466 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA58143.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY To H.influenzae HI_0575. {ECO 0000305}. # eggNOG COG2964 LUCA # eggNOG ENOG4105WWK Bacteria BLAST swissprot:YHEO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHEO_ECOLI BioCyc ECOL316407:JW5703-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5703-MONOMER BioCyc EcoCyc:G7715-MONOMER http://biocyc.org/getid?id=EcoCyc:G7715-MONOMER DIP DIP-12311N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12311N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2736 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2736 EcoGene EG12899 http://www.ecogene.org/geneInfo.php?eg_id=EG12899 EnsemblBacteria AAC76371 http://www.ensemblgenomes.org/id/AAC76371 EnsemblBacteria AAC76371 http://www.ensemblgenomes.org/id/AAC76371 EnsemblBacteria BAE77945 http://www.ensemblgenomes.org/id/BAE77945 EnsemblBacteria BAE77945 http://www.ensemblgenomes.org/id/BAE77945 EnsemblBacteria BAE77945 http://www.ensemblgenomes.org/id/BAE77945 EnsemblBacteria b3346 http://www.ensemblgenomes.org/id/b3346 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GeneID 947851 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947851 HOGENOM HOG000192034 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000192034&db=HOGENOM6 InParanoid P64624 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P64624 InterPro IPR013559 http://www.ebi.ac.uk/interpro/entry/IPR013559 KEGG_Gene ecj:JW5703 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5703 KEGG_Gene eco:b3346 http://www.genome.jp/dbget-bin/www_bget?eco:b3346 OMA IRNREHR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IRNREHR PSORT swissprot:YHEO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHEO_ECOLI PSORT-B swissprot:YHEO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHEO_ECOLI PSORT2 swissprot:YHEO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHEO_ECOLI Pfam PF08348 http://pfam.xfam.org/family/PF08348 Phobius swissprot:YHEO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHEO_ECOLI PhylomeDB P64624 http://phylomedb.org/?seqid=P64624 ProteinModelPortal P64624 http://www.proteinmodelportal.org/query/uniprot/P64624 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417805 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417805 RefSeq WP_000091466 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000091466 SMR P64624 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P64624 STRING 511145.b3346 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3346&targetmode=cogs UniProtKB YHEO_ECOLI http://www.uniprot.org/uniprot/YHEO_ECOLI UniProtKB-AC P64624 http://www.uniprot.org/uniprot/P64624 charge swissprot:YHEO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHEO_ECOLI eggNOG COG2964 http://eggnogapi.embl.de/nog_data/html/tree/COG2964 eggNOG ENOG4105WWK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105WWK epestfind swissprot:YHEO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHEO_ECOLI garnier swissprot:YHEO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHEO_ECOLI helixturnhelix swissprot:YHEO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHEO_ECOLI hmoment swissprot:YHEO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHEO_ECOLI iep swissprot:YHEO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHEO_ECOLI inforesidue swissprot:YHEO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHEO_ECOLI octanol swissprot:YHEO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHEO_ECOLI pepcoil swissprot:YHEO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHEO_ECOLI pepdigest swissprot:YHEO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHEO_ECOLI pepinfo swissprot:YHEO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHEO_ECOLI pepnet swissprot:YHEO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHEO_ECOLI pepstats swissprot:YHEO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHEO_ECOLI pepwheel swissprot:YHEO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHEO_ECOLI pepwindow swissprot:YHEO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHEO_ECOLI sigcleave swissprot:YHEO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHEO_ECOLI ## Database ID URL or Descriptions # BioGrid 4261388 63 # COFACTOR YBEY_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000255|HAMAP-Rule MF_00009}; Note=Binds 1 zinc ion. {ECO 0000255|HAMAP-Rule MF_00009}; # DISRUPTION PHENOTYPE YBEY_ECOLI Mutants show defects in 16S rRNA maturation, ribosome activity, translational fidelity, and ribosome assembly. They have severe growth defect at high temperatures, essentially no thermotolerance at lethal temperatures. They also show a decrease in polysomes and a large increase in both free 50S and free 30S ribosomal subunits relative to 70S ribosomes. {ECO 0000269|PubMed 19181801, ECO 0000269|PubMed 20639334, ECO 0000269|PubMed 20807199, ECO 0000269|PubMed 23273979}. # ENZYME REGULATION Inhibited by EDTA. {ECO:0000269|PubMed 23273979}. # EcoGene EG13655 ybeY # FUNCTION YBEY_ECOLI Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. Acts together with the RNase R to eliminate defective 70S ribosomes, but not properly matured 70S ribosomes or individual subunits, by a process mediated specifically by the 30S ribosomal subunit. Involved in the processing of 16S, 23S and 5S rRNAs, with a particularly strong effect on maturation at both the 5'-and 3'-ends of 16S rRNA as well as maturation of the 5'-end of 23S and 5S rRNAs. {ECO 0000255|HAMAP-Rule MF_00009, ECO 0000269|PubMed 16511207, ECO 0000269|PubMed 20639334, ECO 0000269|PubMed 20807199, ECO 0000269|PubMed 23273979}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0004222 metalloendopeptidase activity; IEA:InterPro. # GO_function GO:0008270 zinc ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0016151 nickel cation binding; IDA:EcoCyc. # GO_function GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters; IDA:EcoCyc. # GO_process GO:0000478 endonucleolytic cleavage involved in rRNA processing; IMP:EcoCyc. # GO_process GO:0006364 rRNA processing; IMP:UniProtKB. # GO_process GO:0006412 translation; IMP:EcoCyc. # GO_process GO:0009408 response to heat; IMP:EcoCyc. # GO_process GO:0030490 maturation of SSU-rRNA; IMP:EcoCyc. # GO_process GO:0031564 transcription antitermination; IMP:EcoCyc. # GO_process GO:0042254 ribosome biogenesis; IMP:UniProtKB. # GO_process GO:0042274 ribosomal small subunit biogenesis; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0004518 nuclease activity # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006412 translation # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0042254 ribosome biogenesis # Gene3D 3.40.390.30 -; 1. # HAMAP MF_00009 Endoribonucl_YbeY # INDUCTION By heat shock. {ECO:0000269|PubMed 16818608}. # IntAct P0A898 14 # InterPro IPR002036 YbeY # InterPro IPR020549 YbeY_CS # InterPro IPR023091 MetalPrtase_cat_dom_prd # KEGG_Brite ko03009 Ribosome biogenesis # Organism YBEY_ECOLI Escherichia coli (strain K12) # PATRIC 32116507 VBIEscCol129921_0693 # PDB 1XM5 X-ray; 2.70 A; A/B/C/D=1-155 # PIR A64801 A64801 # PROSITE PS01306 UPF0054 # Pfam PF02130 UPF0054 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Endoribonuclease YbeY {ECO:0000255|HAMAP-Rule MF_00009} # RefSeq NP_415192 NC_000913.3 # RefSeq WP_000084469 NZ_LN832404.1 # SIMILARITY Belongs to the endoribonuclease YbeY family. {ECO:0000255|HAMAP-Rule MF_00009}. # SUBCELLULAR LOCATION YBEY_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00009, ECO 0000269|PubMed 20639334}. # TIGRFAMs TIGR00043 TIGR00043 # eggNOG COG0319 LUCA # eggNOG ENOG4105KGE Bacteria BLAST swissprot:YBEY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBEY_ECOLI BioCyc ECOL316407:JW0656-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0656-MONOMER BioCyc EcoCyc:G6362-MONOMER http://biocyc.org/getid?id=EcoCyc:G6362-MONOMER COG COG0319 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0319 DIP DIP-48144N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48144N DOI 10.1016/j.molcel.2012.11.025 http://dx.doi.org/10.1016/j.molcel.2012.11.025 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1101/gad.1428206 http://dx.doi.org/10.1101/gad.1428206 DOI 10.1107/S1744309105031131 http://dx.doi.org/10.1107/S1744309105031131 DOI 10.1111/j.1365-2958.2010.07351.x http://dx.doi.org/10.1111/j.1365-2958.2010.07351.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00448-10 http://dx.doi.org/10.1128/JB.00448-10 DOI 10.1128/JB.01663-08 http://dx.doi.org/10.1128/JB.01663-08 EC_number EC:3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00009} http://www.genome.jp/dbget-bin/www_bget?EC:3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00009} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 ENZYME 3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00009} http://enzyme.expasy.org/EC/3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00009} EchoBASE EB3419 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3419 EcoGene EG13655 http://www.ecogene.org/geneInfo.php?eg_id=EG13655 EnsemblBacteria AAC73760 http://www.ensemblgenomes.org/id/AAC73760 EnsemblBacteria AAC73760 http://www.ensemblgenomes.org/id/AAC73760 EnsemblBacteria BAA35314 http://www.ensemblgenomes.org/id/BAA35314 EnsemblBacteria BAA35314 http://www.ensemblgenomes.org/id/BAA35314 EnsemblBacteria BAA35314 http://www.ensemblgenomes.org/id/BAA35314 EnsemblBacteria b0659 http://www.ensemblgenomes.org/id/b0659 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004222 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004222 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0016151 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016151 GO_function GO:0016892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016892 GO_process GO:0000478 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000478 GO_process GO:0006364 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006364 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GO_process GO:0030490 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030490 GO_process GO:0031564 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031564 GO_process GO:0042254 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042254 GO_process GO:0042274 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042274 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0042254 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042254 Gene3D 3.40.390.30 http://www.cathdb.info/version/latest/superfamily/3.40.390.30 GeneID 946430 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946430 HAMAP MF_00009 http://hamap.expasy.org/unirule/MF_00009 HOGENOM HOG000132870 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000132870&db=HOGENOM6 InParanoid P0A898 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A898 IntAct P0A898 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A898* IntEnz 3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00009} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_00009} InterPro IPR002036 http://www.ebi.ac.uk/interpro/entry/IPR002036 InterPro IPR020549 http://www.ebi.ac.uk/interpro/entry/IPR020549 InterPro IPR023091 http://www.ebi.ac.uk/interpro/entry/IPR023091 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW0656 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0656 KEGG_Gene eco:b0659 http://www.genome.jp/dbget-bin/www_bget?eco:b0659 KEGG_Orthology KO:K07042 http://www.genome.jp/dbget-bin/www_bget?KO:K07042 MINT MINT-1241301 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1241301 OMA EESHHLN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EESHHLN PDB 1XM5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1XM5 PDBsum 1XM5 http://www.ebi.ac.uk/pdbsum/1XM5 PROSITE PS01306 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01306 PSORT swissprot:YBEY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBEY_ECOLI PSORT-B swissprot:YBEY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBEY_ECOLI PSORT2 swissprot:YBEY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBEY_ECOLI Pfam PF02130 http://pfam.xfam.org/family/PF02130 Phobius swissprot:YBEY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBEY_ECOLI PhylomeDB P0A898 http://phylomedb.org/?seqid=P0A898 ProteinModelPortal P0A898 http://www.proteinmodelportal.org/query/uniprot/P0A898 PubMed 16511207 http://www.ncbi.nlm.nih.gov/pubmed/16511207 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16818608 http://www.ncbi.nlm.nih.gov/pubmed/16818608 PubMed 19181801 http://www.ncbi.nlm.nih.gov/pubmed/19181801 PubMed 20639334 http://www.ncbi.nlm.nih.gov/pubmed/20639334 PubMed 20807199 http://www.ncbi.nlm.nih.gov/pubmed/20807199 PubMed 23273979 http://www.ncbi.nlm.nih.gov/pubmed/23273979 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415192 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415192 RefSeq WP_000084469 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000084469 SMR P0A898 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A898 STRING 511145.b0659 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0659&targetmode=cogs STRING COG0319 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0319&targetmode=cogs TIGRFAMs TIGR00043 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00043 UniProtKB YBEY_ECOLI http://www.uniprot.org/uniprot/YBEY_ECOLI UniProtKB-AC P0A898 http://www.uniprot.org/uniprot/P0A898 charge swissprot:YBEY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBEY_ECOLI eggNOG COG0319 http://eggnogapi.embl.de/nog_data/html/tree/COG0319 eggNOG ENOG4105KGE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KGE epestfind swissprot:YBEY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBEY_ECOLI garnier swissprot:YBEY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBEY_ECOLI helixturnhelix swissprot:YBEY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBEY_ECOLI hmoment swissprot:YBEY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBEY_ECOLI iep swissprot:YBEY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBEY_ECOLI inforesidue swissprot:YBEY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBEY_ECOLI octanol swissprot:YBEY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBEY_ECOLI pepcoil swissprot:YBEY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBEY_ECOLI pepdigest swissprot:YBEY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBEY_ECOLI pepinfo swissprot:YBEY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBEY_ECOLI pepnet swissprot:YBEY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBEY_ECOLI pepstats swissprot:YBEY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBEY_ECOLI pepwheel swissprot:YBEY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBEY_ECOLI pepwindow swissprot:YBEY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBEY_ECOLI sigcleave swissprot:YBEY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBEY_ECOLI ## Database ID URL or Descriptions # AltName ULAD_ECOLI 3-dehydro-L-gulonate-6-phosphate decarboxylase # AltName ULAD_ECOLI KGPDC # AltName ULAD_ECOLI L-ascorbate utilization protein D # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=0.67 mM for 3-keto-L-gulonate-6-P {ECO 0000269|PubMed:15157077}; # BRENDA 4.1.1.85 2026 # BioGrid 4262000 10 # CATALYTIC ACTIVITY ULAD_ECOLI 3-dehydro-L-gulonate 6-phosphate = L-xylulose 5-phosphate + CO(2). # COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI 18420; Note=Binds 1 Mg(2+) ion per subunit.; # EcoGene EG12496 ulaD # FUNCTION ULAD_ECOLI Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P. Is involved in the anaerobic L-ascorbate utilization. {ECO 0000269|PubMed 11741871}. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0004590 orotidine-5'-phosphate decarboxylase activity; IEA:InterPro. # GO_function GO:0033982 3-dehydro-L-gulonate-6-phosphate decarboxylase activity; IDA:EcoCyc. # GO_process GO:0005975 carbohydrate metabolic process; IEA:UniProtKB-KW. # GO_process GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro. # GO_process GO:0019854 L-ascorbic acid catabolic process; IEP:EcoCyc. # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.70 -; 1. # HAMAP MF_01267 UlaD # INDUCTION ULAD_ECOLI Induced by L-ascorbate. Repressed by UlaR. {ECO 0000269|PubMed 12374842, ECO 0000269|PubMed 14996803}. # InterPro IPR001754 OMPdeCOase_dom # InterPro IPR011060 RibuloseP-bd_barrel # InterPro IPR013785 Aldolase_TIM # InterPro IPR023942 3-keto-L-gulonate6Pdecase_UlaD # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00053 Ascorbate and aldarate metabolism # MISCELLANEOUS ULAD_ECOLI The reaction mechanism proceeds via the formation of a Mg(2+) ion-stabilized 1,2-cis-enediolate intermediate. Water molecules competitively shuttle protons from the side chains of His-136 and Arg-139 to alternate faces of this intermediate. The active site is located at the interface of the component polypeptides. # Organism ULAD_ECOLI Escherichia coli (strain K12) # PATHWAY Cofactor degradation; L-ascorbate degradation; D-xylulose 5-phosphate from L-ascorbate step 2/4. # PATRIC 32123967 VBIEscCol129921_4328 # PDB 1KV8 X-ray; 1.62 A; A/B=1-216 # PDB 1KW1 X-ray; 2.20 A; A/B=1-216 # PDB 1Q6L X-ray; 1.80 A; A/B=1-216 # PDB 1Q6O X-ray; 1.20 A; A/B=1-216 # PDB 1Q6Q X-ray; 1.70 A; A/B=1-216 # PDB 1Q6R X-ray; 1.76 A; A/B=1-216 # PDB 1SO3 X-ray; 1.90 A; A/B=1-216 # PDB 1SO4 X-ray; 1.70 A; A/B=1-216 # PDB 1SO5 X-ray; 1.80 A; A/B=1-216 # PDB 1SO6 X-ray; 1.90 A; A/B=1-216 # PDB 1XBV X-ray; 1.66 A; A/B=1-216 # PDB 1XBX X-ray; 1.81 A; A/B=1-216 # PDB 1XBY X-ray; 1.58 A; A/B=1-216 # PDB 1XBZ X-ray; 1.80 A; A/B=1-216 # PIR S56421 S56421 # Pfam PF00215 OMPdecase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ULAD_ECOLI 3-keto-L-gulonate-6-phosphate decarboxylase UlaD # RefSeq NP_418617 NC_000913.3 # RefSeq WP_000056749 NZ_LN832404.1 # SIMILARITY Belongs to the HPS/KGPDC family. KGPDC subfamily. {ECO 0000305}. # SMART SM00934 OMPdecase # SUBUNIT ULAD_ECOLI Homodimer. {ECO 0000269|PubMed 11900527, ECO 0000269|PubMed 15157078, ECO 0000269|PubMed 15697207}. # SUPFAM SSF51366 SSF51366 # UniPathway UPA00263 UER00378 # eggNOG COG0269 LUCA # eggNOG ENOG4105H6Q Bacteria BLAST swissprot:ULAD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ULAD_ECOLI BioCyc ECOL316407:JW4154-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4154-MONOMER BioCyc EcoCyc:G7858-MONOMER http://biocyc.org/getid?id=EcoCyc:G7858-MONOMER BioCyc MetaCyc:G7858-MONOMER http://biocyc.org/getid?id=MetaCyc:G7858-MONOMER COG COG0269 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0269 DIP DIP-10869N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10869N DOI 10.1021/bi012174e http://dx.doi.org/10.1021/bi012174e DOI 10.1021/bi0348819 http://dx.doi.org/10.1021/bi0348819 DOI 10.1021/bi0478143 http://dx.doi.org/10.1021/bi0478143 DOI 10.1021/bi047815v http://dx.doi.org/10.1021/bi047815v DOI 10.1021/bi0497392 http://dx.doi.org/10.1021/bi0497392 DOI 10.1021/bi049741t http://dx.doi.org/10.1021/bi049741t DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1099/00221287-143-8-2519 http://dx.doi.org/10.1099/00221287-143-8-2519 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.1.302-306.2002 http://dx.doi.org/10.1128/JB.184.1.302-306.2002 DOI 10.1128/JB.184.21.6065-6068.2002 http://dx.doi.org/10.1128/JB.184.21.6065-6068.2002 DOI 10.1128/JB.186.6.1720-1728.2004 http://dx.doi.org/10.1128/JB.186.6.1720-1728.2004 EC_number EC:4.1.1.85 http://www.genome.jp/dbget-bin/www_bget?EC:4.1.1.85 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 4.1.1.85 http://enzyme.expasy.org/EC/4.1.1.85 EchoBASE EB2389 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2389 EcoGene EG12496 http://www.ecogene.org/geneInfo.php?eg_id=EG12496 EnsemblBacteria AAC77153 http://www.ensemblgenomes.org/id/AAC77153 EnsemblBacteria AAC77153 http://www.ensemblgenomes.org/id/AAC77153 EnsemblBacteria BAE78197 http://www.ensemblgenomes.org/id/BAE78197 EnsemblBacteria BAE78197 http://www.ensemblgenomes.org/id/BAE78197 EnsemblBacteria BAE78197 http://www.ensemblgenomes.org/id/BAE78197 EnsemblBacteria b4196 http://www.ensemblgenomes.org/id/b4196 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0004590 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004590 GO_function GO:0033982 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033982 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GO_process GO:0006207 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006207 GO_process GO:0019854 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019854 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 948714 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948714 HAMAP MF_01267 http://hamap.expasy.org/unirule/MF_01267 HOGENOM HOG000226068 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000226068&db=HOGENOM6 InParanoid P39304 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39304 IntAct P39304 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39304* IntEnz 4.1.1.85 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.1.85 InterPro IPR001754 http://www.ebi.ac.uk/interpro/entry/IPR001754 InterPro IPR011060 http://www.ebi.ac.uk/interpro/entry/IPR011060 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR023942 http://www.ebi.ac.uk/interpro/entry/IPR023942 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4154 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4154 KEGG_Gene eco:b4196 http://www.genome.jp/dbget-bin/www_bget?eco:b4196 KEGG_Orthology KO:K03078 http://www.genome.jp/dbget-bin/www_bget?KO:K03078 KEGG_Pathway ko00053 http://www.genome.jp/kegg-bin/show_pathway?ko00053 KEGG_Reaction rn:R07125 http://www.genome.jp/dbget-bin/www_bget?rn:R07125 OMA TIPTMKA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TIPTMKA PDB 1KV8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1KV8 PDB 1KW1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1KW1 PDB 1Q6L http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q6L PDB 1Q6O http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q6O PDB 1Q6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q6Q PDB 1Q6R http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q6R PDB 1SO3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1SO3 PDB 1SO4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1SO4 PDB 1SO5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1SO5 PDB 1SO6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1SO6 PDB 1XBV http://www.ebi.ac.uk/pdbe-srv/view/entry/1XBV PDB 1XBX http://www.ebi.ac.uk/pdbe-srv/view/entry/1XBX PDB 1XBY http://www.ebi.ac.uk/pdbe-srv/view/entry/1XBY PDB 1XBZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1XBZ PDBsum 1KV8 http://www.ebi.ac.uk/pdbsum/1KV8 PDBsum 1KW1 http://www.ebi.ac.uk/pdbsum/1KW1 PDBsum 1Q6L http://www.ebi.ac.uk/pdbsum/1Q6L PDBsum 1Q6O http://www.ebi.ac.uk/pdbsum/1Q6O PDBsum 1Q6Q http://www.ebi.ac.uk/pdbsum/1Q6Q PDBsum 1Q6R http://www.ebi.ac.uk/pdbsum/1Q6R PDBsum 1SO3 http://www.ebi.ac.uk/pdbsum/1SO3 PDBsum 1SO4 http://www.ebi.ac.uk/pdbsum/1SO4 PDBsum 1SO5 http://www.ebi.ac.uk/pdbsum/1SO5 PDBsum 1SO6 http://www.ebi.ac.uk/pdbsum/1SO6 PDBsum 1XBV http://www.ebi.ac.uk/pdbsum/1XBV PDBsum 1XBX http://www.ebi.ac.uk/pdbsum/1XBX PDBsum 1XBY http://www.ebi.ac.uk/pdbsum/1XBY PDBsum 1XBZ http://www.ebi.ac.uk/pdbsum/1XBZ PSORT swissprot:ULAD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ULAD_ECOLI PSORT-B swissprot:ULAD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ULAD_ECOLI PSORT2 swissprot:ULAD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ULAD_ECOLI Pfam PF00215 http://pfam.xfam.org/family/PF00215 Phobius swissprot:ULAD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ULAD_ECOLI PhylomeDB P39304 http://phylomedb.org/?seqid=P39304 ProteinModelPortal P39304 http://www.proteinmodelportal.org/query/uniprot/P39304 PubMed 11741871 http://www.ncbi.nlm.nih.gov/pubmed/11741871 PubMed 11900527 http://www.ncbi.nlm.nih.gov/pubmed/11900527 PubMed 12374842 http://www.ncbi.nlm.nih.gov/pubmed/12374842 PubMed 14567674 http://www.ncbi.nlm.nih.gov/pubmed/14567674 PubMed 14996803 http://www.ncbi.nlm.nih.gov/pubmed/14996803 PubMed 15157077 http://www.ncbi.nlm.nih.gov/pubmed/15157077 PubMed 15157078 http://www.ncbi.nlm.nih.gov/pubmed/15157078 PubMed 15697206 http://www.ncbi.nlm.nih.gov/pubmed/15697206 PubMed 15697207 http://www.ncbi.nlm.nih.gov/pubmed/15697207 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9274005 http://www.ncbi.nlm.nih.gov/pubmed/9274005 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418617 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418617 RefSeq WP_000056749 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000056749 SMART SM00934 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00934 SMR P39304 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39304 STRING 511145.b4196 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4196&targetmode=cogs STRING COG0269 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0269&targetmode=cogs SUPFAM SSF51366 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51366 SWISS-2DPAGE P39304 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P39304 UniProtKB ULAD_ECOLI http://www.uniprot.org/uniprot/ULAD_ECOLI UniProtKB-AC P39304 http://www.uniprot.org/uniprot/P39304 charge swissprot:ULAD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ULAD_ECOLI eggNOG COG0269 http://eggnogapi.embl.de/nog_data/html/tree/COG0269 eggNOG ENOG4105H6Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105H6Q epestfind swissprot:ULAD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ULAD_ECOLI garnier swissprot:ULAD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ULAD_ECOLI helixturnhelix swissprot:ULAD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ULAD_ECOLI hmoment swissprot:ULAD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ULAD_ECOLI iep swissprot:ULAD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ULAD_ECOLI inforesidue swissprot:ULAD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ULAD_ECOLI octanol swissprot:ULAD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ULAD_ECOLI pepcoil swissprot:ULAD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ULAD_ECOLI pepdigest swissprot:ULAD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ULAD_ECOLI pepinfo swissprot:ULAD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ULAD_ECOLI pepnet swissprot:ULAD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ULAD_ECOLI pepstats swissprot:ULAD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ULAD_ECOLI pepwheel swissprot:ULAD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ULAD_ECOLI pepwindow swissprot:ULAD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ULAD_ECOLI sigcleave swissprot:ULAD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ULAD_ECOLI ## Database ID URL or Descriptions # BioGrid 4261783 6 # EcoGene EG11925 yjbG # GO_process GO:0045226 extracellular polysaccharide biosynthetic process; IMP:EcoCyc. # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # InterPro IPR010425 DUF1017 # Organism YJBG_ECOLI Escherichia coli (strain K12) # PATRIC 32123585 VBIEscCol129921_4141 # PIR C65210 C65210 # Pfam PF06251 Caps_synth_GfcC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJBG_ECOLI Uncharacterized protein YjbG # RefSeq NP_418452 NC_000913.3 # RefSeq WP_000595558 NZ_LN832404.1 # SIMILARITY To E.coli YmcB. {ECO 0000305}. # eggNOG ENOG4108Q9C Bacteria # eggNOG ENOG4111E8R LUCA BLAST swissprot:YJBG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJBG_ECOLI BioCyc ECOL316407:JW3988-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3988-MONOMER BioCyc EcoCyc:EG11925-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11925-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1869 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1869 EcoGene EG11925 http://www.ecogene.org/geneInfo.php?eg_id=EG11925 EnsemblBacteria AAC76998 http://www.ensemblgenomes.org/id/AAC76998 EnsemblBacteria AAC76998 http://www.ensemblgenomes.org/id/AAC76998 EnsemblBacteria BAE78030 http://www.ensemblgenomes.org/id/BAE78030 EnsemblBacteria BAE78030 http://www.ensemblgenomes.org/id/BAE78030 EnsemblBacteria BAE78030 http://www.ensemblgenomes.org/id/BAE78030 EnsemblBacteria b4028 http://www.ensemblgenomes.org/id/b4028 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0045226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045226 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 948526 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948526 HOGENOM HOG000126863 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126863&db=HOGENOM6 InterPro IPR010425 http://www.ebi.ac.uk/interpro/entry/IPR010425 KEGG_Gene ecj:JW3988 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3988 KEGG_Gene eco:b4028 http://www.genome.jp/dbget-bin/www_bget?eco:b4028 OMA RQPIAYW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RQPIAYW PSORT swissprot:YJBG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJBG_ECOLI PSORT-B swissprot:YJBG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJBG_ECOLI PSORT2 swissprot:YJBG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJBG_ECOLI Pfam PF06251 http://pfam.xfam.org/family/PF06251 Phobius swissprot:YJBG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJBG_ECOLI ProteinModelPortal P32688 http://www.proteinmodelportal.org/query/uniprot/P32688 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418452 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418452 RefSeq WP_000595558 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000595558 SMR P32688 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32688 STRING 511145.b4028 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4028&targetmode=cogs UniProtKB YJBG_ECOLI http://www.uniprot.org/uniprot/YJBG_ECOLI UniProtKB-AC P32688 http://www.uniprot.org/uniprot/P32688 charge swissprot:YJBG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJBG_ECOLI eggNOG ENOG4108Q9C http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Q9C eggNOG ENOG4111E8R http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111E8R epestfind swissprot:YJBG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJBG_ECOLI garnier swissprot:YJBG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJBG_ECOLI helixturnhelix swissprot:YJBG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJBG_ECOLI hmoment swissprot:YJBG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJBG_ECOLI iep swissprot:YJBG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJBG_ECOLI inforesidue swissprot:YJBG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJBG_ECOLI octanol swissprot:YJBG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJBG_ECOLI pepcoil swissprot:YJBG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJBG_ECOLI pepdigest swissprot:YJBG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJBG_ECOLI pepinfo swissprot:YJBG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJBG_ECOLI pepnet swissprot:YJBG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJBG_ECOLI pepstats swissprot:YJBG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJBG_ECOLI pepwheel swissprot:YJBG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJBG_ECOLI pepwindow swissprot:YJBG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJBG_ECOLI sigcleave swissprot:YJBG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJBG_ECOLI ## Database ID URL or Descriptions # BioGrid 4263045 12 # CDD cd06660 Aldo_ket_red # EcoGene EG13420 ydhF # FUNCTION YDHF_ECOLI May function as oxidoreductase. {ECO 0000305}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0016491 oxidoreductase activity; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # Gene3D 3.20.20.100 -; 1. # InterPro IPR001395 Aldo/ket_red/Kv-b # InterPro IPR020471 Aldo/keto_reductase # InterPro IPR023210 NADP_OxRdtase_dom # Organism YDHF_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11732 PTHR11732 # PATRIC 32118596 VBIEscCol129921_1718 # PDB 1OG6 X-ray; 2.80 A; A/B/C=2-298 # PDB 1UR3 X-ray; 2.57 A; M=2-298 # PIR A64922 A64922 # PRINTS PR00069 ALDKETRDTASE # Pfam PF00248 Aldo_ket_red # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDHF_ECOLI Oxidoreductase YdhF # RefSeq WP_000250656 NZ_LN832404.1 # RefSeq YP_025305 NC_000913.3 # SIMILARITY Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily. {ECO 0000305}. # SUPFAM SSF51430 SSF51430 # TCDB 8.A.5.1 the voltage-gated k(+) channel -subunit (kv) family # eggNOG COG4989 LUCA # eggNOG ENOG4107RGM Bacteria BLAST swissprot:YDHF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDHF_ECOLI BioCyc ECOL316407:JW1639-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1639-MONOMER BioCyc EcoCyc:G6887-MONOMER http://biocyc.org/getid?id=EcoCyc:G6887-MONOMER DOI 10.1023/A:1026177202925 http://dx.doi.org/10.1023/A:1026177202925 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- EchoBASE EB3196 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3196 EcoGene EG13420 http://www.ecogene.org/geneInfo.php?eg_id=EG13420 EnsemblBacteria AAT48134 http://www.ensemblgenomes.org/id/AAT48134 EnsemblBacteria AAT48134 http://www.ensemblgenomes.org/id/AAT48134 EnsemblBacteria BAE76490 http://www.ensemblgenomes.org/id/BAE76490 EnsemblBacteria BAE76490 http://www.ensemblgenomes.org/id/BAE76490 EnsemblBacteria BAE76490 http://www.ensemblgenomes.org/id/BAE76490 EnsemblBacteria b1647 http://www.ensemblgenomes.org/id/b1647 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 Gene3D 3.20.20.100 http://www.cathdb.info/version/latest/superfamily/3.20.20.100 GeneID 946960 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946960 HOGENOM HOG000250282 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000250282&db=HOGENOM6 InParanoid P76187 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76187 IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR001395 http://www.ebi.ac.uk/interpro/entry/IPR001395 InterPro IPR020471 http://www.ebi.ac.uk/interpro/entry/IPR020471 InterPro IPR023210 http://www.ebi.ac.uk/interpro/entry/IPR023210 KEGG_Gene ecj:JW1639 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1639 KEGG_Gene eco:b1647 http://www.genome.jp/dbget-bin/www_bget?eco:b1647 OMA AGTMTWG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AGTMTWG PANTHER PTHR11732 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11732 PDB 1OG6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1OG6 PDB 1UR3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1UR3 PDBsum 1OG6 http://www.ebi.ac.uk/pdbsum/1OG6 PDBsum 1UR3 http://www.ebi.ac.uk/pdbsum/1UR3 PRINTS PR00069 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00069 PSORT swissprot:YDHF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDHF_ECOLI PSORT-B swissprot:YDHF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDHF_ECOLI PSORT2 swissprot:YDHF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDHF_ECOLI Pfam PF00248 http://pfam.xfam.org/family/PF00248 Phobius swissprot:YDHF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDHF_ECOLI PhylomeDB P76187 http://phylomedb.org/?seqid=P76187 ProteinModelPortal P76187 http://www.proteinmodelportal.org/query/uniprot/P76187 PubMed 14649299 http://www.ncbi.nlm.nih.gov/pubmed/14649299 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000250656 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000250656 RefSeq YP_025305 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_025305 SMR P76187 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76187 STRING 511145.b1647 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1647&targetmode=cogs SUPFAM SSF51430 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51430 TCDB 8.A.5.1 http://www.tcdb.org/search/result.php?tc=8.A.5.1 UniProtKB YDHF_ECOLI http://www.uniprot.org/uniprot/YDHF_ECOLI UniProtKB-AC P76187 http://www.uniprot.org/uniprot/P76187 charge swissprot:YDHF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDHF_ECOLI eggNOG COG4989 http://eggnogapi.embl.de/nog_data/html/tree/COG4989 eggNOG ENOG4107RGM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107RGM epestfind swissprot:YDHF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDHF_ECOLI garnier swissprot:YDHF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDHF_ECOLI helixturnhelix swissprot:YDHF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDHF_ECOLI hmoment swissprot:YDHF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDHF_ECOLI iep swissprot:YDHF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDHF_ECOLI inforesidue swissprot:YDHF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDHF_ECOLI octanol swissprot:YDHF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDHF_ECOLI pepcoil swissprot:YDHF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDHF_ECOLI pepdigest swissprot:YDHF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDHF_ECOLI pepinfo swissprot:YDHF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDHF_ECOLI pepnet swissprot:YDHF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDHF_ECOLI pepstats swissprot:YDHF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDHF_ECOLI pepwheel swissprot:YDHF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDHF_ECOLI pepwindow swissprot:YDHF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDHF_ECOLI sigcleave swissprot:YDHF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDHF_ECOLI ## Database ID URL or Descriptions # BioGrid 4259791 5 # EcoGene EG13564 ecpB # FUNCTION ECPB_ECOLI Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition (By similarity). {ECO 0000250}. # INDUCTION Negatively regulated by H-NS. Positively regulated by IHF and EcpR (By similarity). {ECO 0000250}. # INTERACTION ECPB_ECOLI P62620 ispG; NbExp=2; IntAct=EBI-1113651, EBI-550338; # IntAct P77188 53 # InterPro IPR008962 PapD-like # MISCELLANEOUS Not expressed under classical laboratory conditions, but is functional when constitutively expressed (PubMed:11466275 and PubMed 20522494). # Organism ECPB_ECOLI Escherichia coli (strain K12) # PATRIC 32115707 VBIEscCol129921_0296 # PDB 5DFK X-ray; 2.40 A; A=21-222 # PIR D64755 D64755 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ECPB_ECOLI Probable fimbrial chaperone EcpB # RefSeq NP_414826 NC_000913.3 # RefSeq WP_000716398 NZ_LN832404.1 # SIMILARITY Belongs to the EcpB/EcpE family. {ECO 0000305}. # SUPFAM SSF49354 SSF49354 # eggNOG ENOG4108NN8 Bacteria # eggNOG ENOG41119MM LUCA BLAST swissprot:ECPB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ECPB_ECOLI BioCyc ECOL316407:JW0286-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0286-MONOMER BioCyc EcoCyc:G6163-MONOMER http://biocyc.org/getid?id=EcoCyc:G6163-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1099/mic.0.039610-0 http://dx.doi.org/10.1099/mic.0.039610-0 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.183.16.4727-4736.2001 http://dx.doi.org/10.1128/JB.183.16.4727-4736.2001 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB3334 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3334 EcoGene EG13564 http://www.ecogene.org/geneInfo.php?eg_id=EG13564 EnsemblBacteria AAC73395 http://www.ensemblgenomes.org/id/AAC73395 EnsemblBacteria AAC73395 http://www.ensemblgenomes.org/id/AAC73395 EnsemblBacteria BAE76076 http://www.ensemblgenomes.org/id/BAE76076 EnsemblBacteria BAE76076 http://www.ensemblgenomes.org/id/BAE76076 EnsemblBacteria BAE76076 http://www.ensemblgenomes.org/id/BAE76076 EnsemblBacteria b0292 http://www.ensemblgenomes.org/id/b0292 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 948806 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948806 HOGENOM HOG000269492 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000269492&db=HOGENOM6 IntAct P77188 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77188* InterPro IPR008962 http://www.ebi.ac.uk/interpro/entry/IPR008962 KEGG_Gene ecj:JW0286 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0286 KEGG_Gene eco:b0292 http://www.genome.jp/dbget-bin/www_bget?eco:b0292 OMA KVIPMDK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KVIPMDK PDB 5DFK http://www.ebi.ac.uk/pdbe-srv/view/entry/5DFK PDBsum 5DFK http://www.ebi.ac.uk/pdbsum/5DFK PSORT swissprot:ECPB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ECPB_ECOLI PSORT-B swissprot:ECPB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ECPB_ECOLI PSORT2 swissprot:ECPB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ECPB_ECOLI Phobius swissprot:ECPB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ECPB_ECOLI ProteinModelPortal P77188 http://www.proteinmodelportal.org/query/uniprot/P77188 PubMed 11466275 http://www.ncbi.nlm.nih.gov/pubmed/11466275 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20522494 http://www.ncbi.nlm.nih.gov/pubmed/20522494 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414826 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414826 RefSeq WP_000716398 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000716398 SMR P77188 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77188 STRING 511145.b0292 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0292&targetmode=cogs SUPFAM SSF49354 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49354 UniProtKB ECPB_ECOLI http://www.uniprot.org/uniprot/ECPB_ECOLI UniProtKB-AC P77188 http://www.uniprot.org/uniprot/P77188 charge swissprot:ECPB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ECPB_ECOLI eggNOG ENOG4108NN8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108NN8 eggNOG ENOG41119MM http://eggnogapi.embl.de/nog_data/html/tree/ENOG41119MM epestfind swissprot:ECPB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ECPB_ECOLI garnier swissprot:ECPB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ECPB_ECOLI helixturnhelix swissprot:ECPB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ECPB_ECOLI hmoment swissprot:ECPB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ECPB_ECOLI iep swissprot:ECPB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ECPB_ECOLI inforesidue swissprot:ECPB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ECPB_ECOLI octanol swissprot:ECPB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ECPB_ECOLI pepcoil swissprot:ECPB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ECPB_ECOLI pepdigest swissprot:ECPB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ECPB_ECOLI pepinfo swissprot:ECPB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ECPB_ECOLI pepnet swissprot:ECPB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ECPB_ECOLI pepstats swissprot:ECPB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ECPB_ECOLI pepwheel swissprot:ECPB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ECPB_ECOLI pepwindow swissprot:ECPB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ECPB_ECOLI sigcleave swissprot:ECPB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ECPB_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES YIDA_ECOLI Kinetic parameters KM=0.019 mM for Ery4P (in the presence of magnesium ion as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; KM=0.033 mM for Imido-di-P (in the presence of magnesium ion as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; KM=0.21 mM for Glu1P (in the presence of magnesium ion as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; KM=0.39 mM for Fru1P (in the presence of magnesium ion as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; KM=0.44 mM for Fru6P (in the presence of magnesium ion as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; KM=0.45 mM for Ribu5P (in the presence of magnesium ion as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; KM=0.54 mM for Man1P (in the presence of magnesium ion as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; KM=0.81 mM for Glu6P (in the presence of magnesium ion as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; KM=3.8 mM for Acetyl-P (in the presence of magnesium ion as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; pH dependence Optimum pH is between 6 and 7.5. {ECO 0000269|PubMed 16990279}; # BioGrid 4262577 7 # CATALYTIC ACTIVITY Sugar phosphate + H(2)O = sugar + phosphate. {ECO:0000269|PubMed 16990279}. # COFACTOR YIDA_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 16990279}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 16990279}; Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000269|PubMed 16990279}; Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 16990279}; Note=Magnesium. Can also use other divalent metal cations as manganese, cobalt or zinc. {ECO 0000269|PubMed 16990279}; # EcoGene EG11195 yidA # FUNCTION YIDA_ECOLI Catalyzes the dephosphorylation of different sugar phosphates including erythrose-4-phosphate (Ery4P), ribose-5- phosphate (Ribu5P), fructose-1-phosphate (Fru1P), fructose-6- phosphate (Fru6P), glucose-6-P (Glu6P), and also imidodiphosphate (Imido-di-P) and acetyl phosphate (Acetyl-P). Selectively hydrolyzes alpha-D-glucose-1-phosphate (Glu1P) and has no activity with the beta form. {ECO 0000269|PubMed 15808744, ECO 0000269|PubMed 16990279}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IDA:EcoliWiki. # GO_function GO:0016791 phosphatase activity; IDA:EcoliWiki. # GO_function GO:0050308 sugar-phosphatase activity; IDA:EcoliWiki. # GO_process GO:0044283 small molecule biosynthetic process; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.1000 -; 2. # IntAct P0A8Y5 10 # InterPro IPR000150 Hypothet_cof # InterPro IPR006379 HAD-SF_hydro_IIB # InterPro IPR023214 HAD-like_dom # Organism YIDA_ECOLI Escherichia coli (strain K12) # PATRIC 32122889 VBIEscCol129921_3820 # PDB 1RKQ X-ray; 1.40 A; A/B=2-270 # PIR B65172 QQECGB # PROSITE PS01228 COF_1 # PROSITE PS01229 COF_2 # Pfam PF08282 Hydrolase_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIDA_ECOLI Sugar phosphatase YidA # RefSeq NP_418152 NC_000913.3 # RefSeq WP_000985549 NZ_LN832404.1 # SIMILARITY Belongs to the HAD-like hydrolase superfamily. Cof family. {ECO 0000305}. # SUBUNIT Homodimer. {ECO 0000269|Ref.7}. # SUPFAM SSF56784 SSF56784 # TIGRFAMs TIGR00099 Cof-subfamily # TIGRFAMs TIGR01484 HAD-SF-IIB # eggNOG COG0561 LUCA # eggNOG ENOG410667J Bacteria BLAST swissprot:YIDA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIDA_ECOLI BioCyc ECOL316407:JW3674-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3674-MONOMER BioCyc EcoCyc:EG11195-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11195-MONOMER BioCyc MetaCyc:EG11195-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11195-MONOMER COG COG0561 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0561 DIP DIP-36033N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36033N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1016/j.fmrre.2004.12.006 http://dx.doi.org/10.1016/j.fmrre.2004.12.006 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M605449200 http://dx.doi.org/10.1074/jbc.M605449200 DOI 10.1093/nar/15.2.771 http://dx.doi.org/10.1093/nar/15.2.771 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.3.23 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.23 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X04341 http://www.ebi.ac.uk/ena/data/view/X04341 ENZYME 3.1.3.23 http://enzyme.expasy.org/EC/3.1.3.23 EchoBASE EB1181 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1181 EcoGene EG11195 http://www.ecogene.org/geneInfo.php?eg_id=EG11195 EnsemblBacteria AAC76720 http://www.ensemblgenomes.org/id/AAC76720 EnsemblBacteria AAC76720 http://www.ensemblgenomes.org/id/AAC76720 EnsemblBacteria BAE77597 http://www.ensemblgenomes.org/id/BAE77597 EnsemblBacteria BAE77597 http://www.ensemblgenomes.org/id/BAE77597 EnsemblBacteria BAE77597 http://www.ensemblgenomes.org/id/BAE77597 EnsemblBacteria b3697 http://www.ensemblgenomes.org/id/b3697 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GO_function GO:0050308 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050308 GO_process GO:0044283 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044283 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.1000 http://www.cathdb.info/version/latest/superfamily/3.40.50.1000 GeneID 948204 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948204 HOGENOM HOG000184780 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000184780&db=HOGENOM6 InParanoid P0A8Y5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8Y5 IntAct P0A8Y5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8Y5* IntEnz 3.1.3.23 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.23 InterPro IPR000150 http://www.ebi.ac.uk/interpro/entry/IPR000150 InterPro IPR006379 http://www.ebi.ac.uk/interpro/entry/IPR006379 InterPro IPR023214 http://www.ebi.ac.uk/interpro/entry/IPR023214 KEGG_Gene ecj:JW3674 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3674 KEGG_Gene eco:b3697 http://www.genome.jp/dbget-bin/www_bget?eco:b3697 KEGG_Orthology KO:K07024 http://www.genome.jp/dbget-bin/www_bget?KO:K07024 MINT MINT-1238706 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1238706 OMA LFYNGSM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LFYNGSM PDB 1RKQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1RKQ PDBsum 1RKQ http://www.ebi.ac.uk/pdbsum/1RKQ PROSITE PS01228 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01228 PROSITE PS01229 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01229 PSORT swissprot:YIDA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIDA_ECOLI PSORT-B swissprot:YIDA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIDA_ECOLI PSORT2 swissprot:YIDA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIDA_ECOLI Pfam PF08282 http://pfam.xfam.org/family/PF08282 Phobius swissprot:YIDA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIDA_ECOLI PhylomeDB P0A8Y5 http://phylomedb.org/?seqid=P0A8Y5 ProteinModelPortal P0A8Y5 http://www.proteinmodelportal.org/query/uniprot/P0A8Y5 PubMed 15808744 http://www.ncbi.nlm.nih.gov/pubmed/15808744 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16990279 http://www.ncbi.nlm.nih.gov/pubmed/16990279 PubMed 3029692 http://www.ncbi.nlm.nih.gov/pubmed/3029692 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418152 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418152 RefSeq WP_000985549 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000985549 SMR P0A8Y5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8Y5 STRING 511145.b3697 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3697&targetmode=cogs STRING COG0561 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0561&targetmode=cogs SUPFAM SSF56784 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784 TIGRFAMs TIGR00099 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00099 TIGRFAMs TIGR01484 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01484 UniProtKB YIDA_ECOLI http://www.uniprot.org/uniprot/YIDA_ECOLI UniProtKB-AC P0A8Y5 http://www.uniprot.org/uniprot/P0A8Y5 charge swissprot:YIDA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIDA_ECOLI eggNOG COG0561 http://eggnogapi.embl.de/nog_data/html/tree/COG0561 eggNOG ENOG410667J http://eggnogapi.embl.de/nog_data/html/tree/ENOG410667J epestfind swissprot:YIDA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIDA_ECOLI garnier swissprot:YIDA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIDA_ECOLI helixturnhelix swissprot:YIDA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIDA_ECOLI hmoment swissprot:YIDA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIDA_ECOLI iep swissprot:YIDA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIDA_ECOLI inforesidue swissprot:YIDA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIDA_ECOLI octanol swissprot:YIDA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIDA_ECOLI pepcoil swissprot:YIDA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIDA_ECOLI pepdigest swissprot:YIDA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIDA_ECOLI pepinfo swissprot:YIDA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIDA_ECOLI pepnet swissprot:YIDA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIDA_ECOLI pepstats swissprot:YIDA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIDA_ECOLI pepwheel swissprot:YIDA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIDA_ECOLI pepwindow swissprot:YIDA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIDA_ECOLI sigcleave swissprot:YIDA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIDA_ECOLI ## Database ID URL or Descriptions # BioGrid 4263023 15 # ESTHER ecoli-YNBC Monoglyceridelipase_lysophospholip # EcoGene EG13750 ynbC # GO_component GO:0016020 membrane; IBA:GO_Central. # GO_function GO:0016298 lipase activity; IBA:GO_Central. # GO_process GO:0006629 lipid metabolic process; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006629 lipid metabolic process # Gene3D 3.40.50.150 -; 1. # Gene3D 3.40.50.1820 -; 1. # INTERACTION YNBC_ECOLI P13458 sbcC; NbExp=2; IntAct=EBI-544837, EBI-546919; # IntAct P76092 20 # InterPro IPR022742 Hydrolase_4 # InterPro IPR022744 MeTrfase_dom_put # InterPro IPR029058 AB_hydrolase # InterPro IPR029063 SAM-dependent_MTases # Organism YNBC_ECOLI Escherichia coli (strain K12) # PATRIC 32118106 VBIEscCol129921_1473 # PIR E64892 E64892 # Pfam PF12146 Hydrolase_4 # Pfam PF12147 Methyltransf_20 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNBC_ECOLI Uncharacterized protein YnbC # RefSeq NP_415928 NC_000913.3 # RefSeq WP_000431845 NZ_LN832404.1 # SUPFAM SSF53335 SSF53335 # SUPFAM SSF53474 SSF53474; 2 # eggNOG COG2267 LUCA # eggNOG ENOG4105E8V Bacteria BLAST swissprot:YNBC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNBC_ECOLI BioCyc ECOL316407:JW1407-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1407-MONOMER BioCyc EcoCyc:G6729-MONOMER http://biocyc.org/getid?id=EcoCyc:G6729-MONOMER DIP DIP-12744N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12744N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D85081 http://www.ebi.ac.uk/ena/data/view/D85081 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3513 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3513 EcoGene EG13750 http://www.ecogene.org/geneInfo.php?eg_id=EG13750 EnsemblBacteria AAC74492 http://www.ensemblgenomes.org/id/AAC74492 EnsemblBacteria AAC74492 http://www.ensemblgenomes.org/id/AAC74492 EnsemblBacteria BAE76431 http://www.ensemblgenomes.org/id/BAE76431 EnsemblBacteria BAE76431 http://www.ensemblgenomes.org/id/BAE76431 EnsemblBacteria BAE76431 http://www.ensemblgenomes.org/id/BAE76431 EnsemblBacteria b1410 http://www.ensemblgenomes.org/id/b1410 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0016298 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016298 GO_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 Gene3D 3.40.50.1820 http://www.cathdb.info/version/latest/superfamily/3.40.50.1820 GeneID 945970 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945970 HOGENOM HOG000259033 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000259033&db=HOGENOM6 InParanoid P76092 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76092 IntAct P76092 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76092* InterPro IPR022742 http://www.ebi.ac.uk/interpro/entry/IPR022742 InterPro IPR022744 http://www.ebi.ac.uk/interpro/entry/IPR022744 InterPro IPR029058 http://www.ebi.ac.uk/interpro/entry/IPR029058 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 KEGG_Gene ecj:JW1407 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1407 KEGG_Gene eco:b1410 http://www.genome.jp/dbget-bin/www_bget?eco:b1410 OMA TWAHDYA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TWAHDYA PSORT swissprot:YNBC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNBC_ECOLI PSORT-B swissprot:YNBC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNBC_ECOLI PSORT2 swissprot:YNBC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNBC_ECOLI Pfam PF12146 http://pfam.xfam.org/family/PF12146 Pfam PF12147 http://pfam.xfam.org/family/PF12147 Phobius swissprot:YNBC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNBC_ECOLI PhylomeDB P76092 http://phylomedb.org/?seqid=P76092 ProteinModelPortal P76092 http://www.proteinmodelportal.org/query/uniprot/P76092 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415928 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415928 RefSeq WP_000431845 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000431845 SMR P76092 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76092 STRING 511145.b1410 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1410&targetmode=cogs SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 SUPFAM SSF53474 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53474 UniProtKB YNBC_ECOLI http://www.uniprot.org/uniprot/YNBC_ECOLI UniProtKB-AC P76092 http://www.uniprot.org/uniprot/P76092 charge swissprot:YNBC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNBC_ECOLI eggNOG COG2267 http://eggnogapi.embl.de/nog_data/html/tree/COG2267 eggNOG ENOG4105E8V http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E8V epestfind swissprot:YNBC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNBC_ECOLI garnier swissprot:YNBC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNBC_ECOLI helixturnhelix swissprot:YNBC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNBC_ECOLI hmoment swissprot:YNBC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNBC_ECOLI iep swissprot:YNBC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNBC_ECOLI inforesidue swissprot:YNBC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNBC_ECOLI octanol swissprot:YNBC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNBC_ECOLI pepcoil swissprot:YNBC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNBC_ECOLI pepdigest swissprot:YNBC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNBC_ECOLI pepinfo swissprot:YNBC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNBC_ECOLI pepnet swissprot:YNBC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNBC_ECOLI pepstats swissprot:YNBC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNBC_ECOLI pepwheel swissprot:YNBC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNBC_ECOLI pepwindow swissprot:YNBC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNBC_ECOLI sigcleave swissprot:YNBC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNBC_ECOLI ## Database ID URL or Descriptions # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # GO_component GO:0019867 outer membrane; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # Gene3D 2.160.20.20 -; 1. # Gene3D 2.40.128.130 -; 1. # IntAct P77286 8 # InterPro IPR004899 Pertactin_central # InterPro IPR005546 Autotransporte_beta # InterPro IPR006315 OM_autotransptr_brl # InterPro IPR011050 Pectin_lyase_fold/virulence # InterPro IPR012332 P22_tailspike_C-like # Organism YDEU_ECOLI Escherichia coli (strain K12) # PIR H64904 H64904 # PROSITE PS51208 AUTOTRANSPORTER # Pfam PF03212 Pertactin # Pfam PF03797 Autotransporter # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDEU_ECOLI Uncharacterized protein YdeU # RefSeq WP_001083595 NZ_LN832404.1 # SIMILARITY Contains 1 autotransporter (TC 1.B.12) domain. {ECO:0000255|PROSITE-ProRule PRU00556}. # SMART SM00869 Autotransporter # SUPFAM SSF103515 SSF103515 # SUPFAM SSF51126 SSF51126 # TIGRFAMs TIGR01414 autotrans_barl # eggNOG COG3468 LUCA BLAST swissprot:YDEU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDEU_ECOLI BioCyc EcoCyc:G6797-MONOMER http://biocyc.org/getid?id=EcoCyc:G6797-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3564 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3564 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0019867 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019867 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 Gene3D 2.160.20.20 http://www.cathdb.info/version/latest/superfamily/2.160.20.20 Gene3D 2.40.128.130 http://www.cathdb.info/version/latest/superfamily/2.40.128.130 InParanoid P77286 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77286 IntAct P77286 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77286* InterPro IPR004899 http://www.ebi.ac.uk/interpro/entry/IPR004899 InterPro IPR005546 http://www.ebi.ac.uk/interpro/entry/IPR005546 InterPro IPR006315 http://www.ebi.ac.uk/interpro/entry/IPR006315 InterPro IPR011050 http://www.ebi.ac.uk/interpro/entry/IPR011050 InterPro IPR012332 http://www.ebi.ac.uk/interpro/entry/IPR012332 OMA WQANISI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WQANISI PROSITE PS51208 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51208 PSORT swissprot:YDEU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDEU_ECOLI PSORT-B swissprot:YDEU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDEU_ECOLI PSORT2 swissprot:YDEU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDEU_ECOLI Pfam PF03212 http://pfam.xfam.org/family/PF03212 Pfam PF03797 http://pfam.xfam.org/family/PF03797 Phobius swissprot:YDEU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDEU_ECOLI ProteinModelPortal P77286 http://www.proteinmodelportal.org/query/uniprot/P77286 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001083595 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001083595 SMART SM00869 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00869 SMR P77286 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77286 STRING 316385.ECDH10B_1640 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316385.ECDH10B_1640&targetmode=cogs SUPFAM SSF103515 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103515 SUPFAM SSF51126 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51126 TIGRFAMs TIGR01414 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01414 UniProtKB YDEU_ECOLI http://www.uniprot.org/uniprot/YDEU_ECOLI UniProtKB-AC P77286 http://www.uniprot.org/uniprot/P77286 charge swissprot:YDEU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDEU_ECOLI eggNOG COG3468 http://eggnogapi.embl.de/nog_data/html/tree/COG3468 epestfind swissprot:YDEU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDEU_ECOLI garnier swissprot:YDEU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDEU_ECOLI helixturnhelix swissprot:YDEU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDEU_ECOLI hmoment swissprot:YDEU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDEU_ECOLI iep swissprot:YDEU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDEU_ECOLI inforesidue swissprot:YDEU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDEU_ECOLI octanol swissprot:YDEU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDEU_ECOLI pepcoil swissprot:YDEU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDEU_ECOLI pepdigest swissprot:YDEU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDEU_ECOLI pepinfo swissprot:YDEU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDEU_ECOLI pepnet swissprot:YDEU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDEU_ECOLI pepstats swissprot:YDEU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDEU_ECOLI pepwheel swissprot:YDEU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDEU_ECOLI pepwindow swissprot:YDEU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDEU_ECOLI sigcleave swissprot:YDEU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDEU_ECOLI ## Database ID URL or Descriptions # AltName FOLB_ECOLI 7,8-dihydroneopterin 2'-epimerase # AltName FOLB_ECOLI 7,8-dihydroneopterin aldolase # AltName FOLB_ECOLI 7,8-dihydroneopterin epimerase # AltName FOLB_ECOLI Dihydroneopterin epimerase # BIOPHYSICOCHEMICAL PROPERTIES FOLB_ECOLI Kinetic parameters KM=64 uM for 7,8-dihydroneopterin in aldolase reaction {ECO 0000269|PubMed 9651328}; KM=45 uM for 7,8-dihydroneopterin in epimerase reaction {ECO 0000269|PubMed 9651328}; KM=36 uM for 7,8-dihydromonapterin in aldolase reaction {ECO 0000269|PubMed 9651328}; KM=57 uM for 7,8-dihydromonapterin in epimerase reaction {ECO 0000269|PubMed 9651328}; Vmax=127 umol/h/mg enzyme toward 7,8-dihydroneopterin in aldolase reaction {ECO 0000269|PubMed 9651328}; Vmax=20.3 umol/h/mg enzyme toward 7,8-dihydroneopterin in epimerase reaction {ECO 0000269|PubMed 9651328}; Vmax=158 umol/h/mg enzyme toward 7,8-dihydromonapterin in aldolase reaction {ECO 0000269|PubMed 9651328}; Vmax=15.6 umol/h/mg enzyme toward 7,8-dihydromonapterin in epimerase reaction {ECO 0000269|PubMed 9651328}; # CATALYTIC ACTIVITY 7,8-dihydroneopterin = 6-hydroxymethyl-7,8- dihydropterin + glycolaldehyde. {ECO:0000269|PubMed 9651328}. # CATALYTIC ACTIVITY 7,8-dihydroneopterin = 7,8-dihydromonapterin. {ECO:0000269|PubMed 9651328}. # CDD cd00534 DHNA_DHNTPE # EcoGene EG11673 folB # FUNCTION FOLB_ECOLI Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6-hydroxymethyldihydropterin, but it can also catalyze the epimerization of carbon 2' of dihydroneopterin to dihydromonapterin at appreciable velocity. {ECO 0000269|PubMed 9651328}. # GO_function GO:0004150 dihydroneopterin aldolase activity; IDA:EcoCyc. # GO_function GO:0016853 isomerase activity; IEA:UniProtKB-KW. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0102083 7,8-dihydromonapterin aldolase activity; IEA:UniProtKB-EC. # GO_process GO:0046654 tetrahydrofolate biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0046656 folic acid biosynthetic process; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # IntAct P0AC16 2 # InterPro IPR006156 Dihydroneopterin_aldolase # InterPro IPR006157 FolB_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00790 Folate biosynthesis # Organism FOLB_ECOLI Escherichia coli (strain K12) # PATHWAY Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2- amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate step 3/4. # PATRIC 32121528 VBIEscCol129921_3151 # PDB 2O90 X-ray; 1.07 A; A=1-122 # PIR H65093 H65093 # Pfam PF02152 FolB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Dihydroneopterin aldolase {ECO:0000303|PubMed 9651328} # RefSeq NP_417530 NC_000913.3 # RefSeq WP_001295541 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA89138.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the DHNA family. {ECO 0000305}. # SMART SM00905 FolB # SUBUNIT Homooctamer. {ECO:0000269|PubMed 9651328}. # TIGRFAMs TIGR00525 folB # TIGRFAMs TIGR00526 folB_dom # UniPathway UPA00077 UER00154 # eggNOG COG1539 LUCA # eggNOG ENOG4107ZVW Bacteria BLAST swissprot:FOLB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FOLB_ECOLI BioCyc ECOL316407:JW3030-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3030-MONOMER BioCyc EcoCyc:H2NEOPTERINALDOL-MONOMER http://biocyc.org/getid?id=EcoCyc:H2NEOPTERINALDOL-MONOMER BioCyc MetaCyc:H2NEOPTERINALDOL-MONOMER http://biocyc.org/getid?id=MetaCyc:H2NEOPTERINALDOL-MONOMER COG COG1539 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1539 DIP DIP-36044N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36044N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.273.28.17418 http://dx.doi.org/10.1074/jbc.273.28.17418 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1186/2045-3701-4-52 http://dx.doi.org/10.1186/2045-3701-4-52 EC_number EC:4.1.2.25 {ECO:0000269|PubMed:9651328} http://www.genome.jp/dbget-bin/www_bget?EC:4.1.2.25 {ECO:0000269|PubMed:9651328} EC_number EC:5.1.99.8 {ECO:0000269|PubMed:9651328} http://www.genome.jp/dbget-bin/www_bget?EC:5.1.99.8 {ECO:0000269|PubMed:9651328} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L12966 http://www.ebi.ac.uk/ena/data/view/L12966 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28379 http://www.ebi.ac.uk/ena/data/view/U28379 ENZYME 4.1.2.25 {ECO:0000269|PubMed:9651328} http://enzyme.expasy.org/EC/4.1.2.25 {ECO:0000269|PubMed:9651328} ENZYME 5.1.99.8 {ECO:0000269|PubMed:9651328} http://enzyme.expasy.org/EC/5.1.99.8 {ECO:0000269|PubMed:9651328} EchoBASE EB1624 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1624 EcoGene EG11673 http://www.ecogene.org/geneInfo.php?eg_id=EG11673 EnsemblBacteria AAC76094 http://www.ensemblgenomes.org/id/AAC76094 EnsemblBacteria AAC76094 http://www.ensemblgenomes.org/id/AAC76094 EnsemblBacteria BAE77109 http://www.ensemblgenomes.org/id/BAE77109 EnsemblBacteria BAE77109 http://www.ensemblgenomes.org/id/BAE77109 EnsemblBacteria BAE77109 http://www.ensemblgenomes.org/id/BAE77109 EnsemblBacteria b3058 http://www.ensemblgenomes.org/id/b3058 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004150 GO_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0102083 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0102083 GO_process GO:0046654 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046654 GO_process GO:0046656 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046656 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GeneID 947544 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947544 HOGENOM HOG000217627 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000217627&db=HOGENOM6 InParanoid P0AC16 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AC16 IntAct P0AC16 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AC16* IntEnz 4.1.2.25 {ECO:0000269|PubMed:9651328} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.2.25 {ECO:0000269|PubMed:9651328} IntEnz 5.1.99.8 {ECO:0000269|PubMed:9651328} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.1.99.8 {ECO:0000269|PubMed:9651328} InterPro IPR006156 http://www.ebi.ac.uk/interpro/entry/IPR006156 InterPro IPR006157 http://www.ebi.ac.uk/interpro/entry/IPR006157 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3030 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3030 KEGG_Gene eco:b3058 http://www.genome.jp/dbget-bin/www_bget?eco:b3058 KEGG_Orthology KO:K01633 http://www.genome.jp/dbget-bin/www_bget?KO:K01633 KEGG_Pathway ko00790 http://www.genome.jp/kegg-bin/show_pathway?ko00790 KEGG_Reaction rn:R03504 http://www.genome.jp/dbget-bin/www_bget?rn:R03504 OMA WEQTIKQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WEQTIKQ PDB 2O90 http://www.ebi.ac.uk/pdbe-srv/view/entry/2O90 PDBsum 2O90 http://www.ebi.ac.uk/pdbsum/2O90 PSORT swissprot:FOLB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FOLB_ECOLI PSORT-B swissprot:FOLB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FOLB_ECOLI PSORT2 swissprot:FOLB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FOLB_ECOLI Pfam PF02152 http://pfam.xfam.org/family/PF02152 Phobius swissprot:FOLB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FOLB_ECOLI PhylomeDB P0AC16 http://phylomedb.org/?seqid=P0AC16 ProteinModelPortal P0AC16 http://www.proteinmodelportal.org/query/uniprot/P0AC16 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 25264482 http://www.ncbi.nlm.nih.gov/pubmed/25264482 PubMed 8389741 http://www.ncbi.nlm.nih.gov/pubmed/8389741 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9651328 http://www.ncbi.nlm.nih.gov/pubmed/9651328 RefSeq NP_417530 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417530 RefSeq WP_001295541 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295541 SMART SM00905 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00905 SMR P0AC16 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AC16 STRING 511145.b3058 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3058&targetmode=cogs STRING COG1539 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1539&targetmode=cogs TIGRFAMs TIGR00525 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00525 TIGRFAMs TIGR00526 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00526 UniProtKB FOLB_ECOLI http://www.uniprot.org/uniprot/FOLB_ECOLI UniProtKB-AC P0AC16 http://www.uniprot.org/uniprot/P0AC16 charge swissprot:FOLB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FOLB_ECOLI eggNOG COG1539 http://eggnogapi.embl.de/nog_data/html/tree/COG1539 eggNOG ENOG4107ZVW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107ZVW epestfind swissprot:FOLB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FOLB_ECOLI garnier swissprot:FOLB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FOLB_ECOLI helixturnhelix swissprot:FOLB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FOLB_ECOLI hmoment swissprot:FOLB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FOLB_ECOLI iep swissprot:FOLB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FOLB_ECOLI inforesidue swissprot:FOLB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FOLB_ECOLI octanol swissprot:FOLB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FOLB_ECOLI pepcoil swissprot:FOLB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FOLB_ECOLI pepdigest swissprot:FOLB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FOLB_ECOLI pepinfo swissprot:FOLB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FOLB_ECOLI pepnet swissprot:FOLB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FOLB_ECOLI pepstats swissprot:FOLB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FOLB_ECOLI pepwheel swissprot:FOLB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FOLB_ECOLI pepwindow swissprot:FOLB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FOLB_ECOLI sigcleave swissprot:FOLB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FOLB_ECOLI ## Database ID URL or Descriptions # AltName Ferric hydroxamate uptake protein D {ECO 0000305} # AltName Ferrichrome-binding periplasmic protein {ECO 0000305} # AltName Iron(III)-hydroxamate-binding protein FhuD {ECO 0000305} # BioGrid 4263041 340 # EcoGene EG10305 fhuD # FUNCTION FHUD_ECOLI Part of the ABC transporter complex FhuCDB involved in iron(3+)-hydroxamate import. Binds the iron(3+)-hydroxamate complex and transfers it to the membrane-bound permease. Required for the transport of all iron(3+)-hydroxamate siderophores such as ferrichrome, gallichrome, desferrioxamine, coprogen, aerobactin, shizokinen, rhodotorulic acid and the antibiotic albomycin. {ECO 0000269|PubMed 10742172, ECO 0000269|PubMed 11805094, ECO 0000269|PubMed 2254301, ECO 0000269|PubMed 8522527}. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_process GO:0006811 ion transport; IEA:UniProtKB-KW. # GO_process GO:0055072 iron ion homeostasis; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0006810 transport # GOslim_process GO:0042592 homeostatic process # INDUCTION Induced 1.3-fold by hydroxyurea. {ECO:0000269|PubMed 20005847}. # IntAct P07822 2 # InterPro IPR002491 ABC_transptr_periplasmic_BD # InterPro IPR008091 Ferrichrome-bd # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00240 Iron complex transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism FHUD_ECOLI Escherichia coli (strain K12) # PATRIC 32115413 VBIEscCol129921_0158 # PDB 1EFD X-ray; 1.90 A; N=31-296 # PDB 1ESZ X-ray; 2.00 A; A=31-296 # PDB 1K2V X-ray; 1.97 A; N=31-296 # PDB 1K7S X-ray; 2.60 A; N=33-296 # PIR H64738 QRECFD # PRINTS PR01715 FERRIBNDNGPP # PROSITE PS50983 FE_B12_PBP # PTM FHUD_ECOLI Exported by the Tat system. The position of the signal peptide cleavage has been experimentally proven. Can also be exported by the Sec system. {ECO 0000269|PubMed 17218314}. # Pfam PF01497 Peripla_BP_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Iron(3+)-hydroxamate-binding protein FhuD {ECO 0000305} # RefSeq NP_414694 NC_000913.3 # RefSeq WP_001310529 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial solute-binding protein 8 family. {ECO 0000305}. # SIMILARITY Contains 1 Fe/B12 periplasmic-binding domain. {ECO:0000255|PROSITE-ProRule PRU00344}. # SUBCELLULAR LOCATION FHUD_ECOLI Periplasm {ECO 0000269|PubMed 17218314}. # SUBUNIT FHUD_ECOLI The complex is composed of two ATP-binding proteins (FhuC), two transmembrane proteins (FhuB) and a solute-binding protein (FhuD) (Probable). FhuD interacts with FhuB (PubMed 8522527, PubMed 9426146). {ECO 0000269|PubMed 8522527, ECO 0000269|PubMed 9426146, ECO 0000305}. # TCDB 3.A.1.14 the atp-binding cassette (abc) superfamily # eggNOG COG0614 LUCA # eggNOG ENOG4105J76 Bacteria BLAST swissprot:FHUD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FHUD_ECOLI BioCyc ECOL316407:JW0148-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0148-MONOMER BioCyc EcoCyc:FHUD-MONOMER http://biocyc.org/getid?id=EcoCyc:FHUD-MONOMER BioCyc MetaCyc:FHUD-MONOMER http://biocyc.org/getid?id=MetaCyc:FHUD-MONOMER COG COG0614 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0614 DOI 10.1007/BF00329835 http://dx.doi.org/10.1007/BF00329835 DOI 10.1007/BF02456611 http://dx.doi.org/10.1007/BF02456611 DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/74048 http://dx.doi.org/10.1038/74048 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1997.6592008.x http://dx.doi.org/10.1046/j.1365-2958.1997.6592008.x DOI 10.1074/jbc.M109385200 http://dx.doi.org/10.1074/jbc.M109385200 DOI 10.1074/jbc.M610507200 http://dx.doi.org/10.1074/jbc.M610507200 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M12486 http://www.ebi.ac.uk/ena/data/view/M12486 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EMBL X05810 http://www.ebi.ac.uk/ena/data/view/X05810 EchoBASE EB0301 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0301 EcoGene EG10305 http://www.ecogene.org/geneInfo.php?eg_id=EG10305 EnsemblBacteria AAC73263 http://www.ensemblgenomes.org/id/AAC73263 EnsemblBacteria AAC73263 http://www.ensemblgenomes.org/id/AAC73263 EnsemblBacteria BAB96728 http://www.ensemblgenomes.org/id/BAB96728 EnsemblBacteria BAB96728 http://www.ensemblgenomes.org/id/BAB96728 EnsemblBacteria BAB96728 http://www.ensemblgenomes.org/id/BAB96728 EnsemblBacteria b0152 http://www.ensemblgenomes.org/id/b0152 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_process GO:0006811 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811 GO_process GO:0055072 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055072 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GeneID 947510 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947510 HOGENOM HOG000285075 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000285075&db=HOGENOM6 InParanoid P07822 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P07822 IntAct P07822 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P07822* InterPro IPR002491 http://www.ebi.ac.uk/interpro/entry/IPR002491 InterPro IPR008091 http://www.ebi.ac.uk/interpro/entry/IPR008091 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0148 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0148 KEGG_Gene eco:b0152 http://www.genome.jp/dbget-bin/www_bget?eco:b0152 KEGG_Orthology KO:K02016 http://www.genome.jp/dbget-bin/www_bget?KO:K02016 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA VLCFDHG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VLCFDHG PDB 1EFD http://www.ebi.ac.uk/pdbe-srv/view/entry/1EFD PDB 1ESZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1ESZ PDB 1K2V http://www.ebi.ac.uk/pdbe-srv/view/entry/1K2V PDB 1K7S http://www.ebi.ac.uk/pdbe-srv/view/entry/1K7S PDBsum 1EFD http://www.ebi.ac.uk/pdbsum/1EFD PDBsum 1ESZ http://www.ebi.ac.uk/pdbsum/1ESZ PDBsum 1K2V http://www.ebi.ac.uk/pdbsum/1K2V PDBsum 1K7S http://www.ebi.ac.uk/pdbsum/1K7S PRINTS PR01715 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01715 PROSITE PS50983 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50983 PSORT swissprot:FHUD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FHUD_ECOLI PSORT-B swissprot:FHUD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FHUD_ECOLI PSORT2 swissprot:FHUD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FHUD_ECOLI Pfam PF01497 http://pfam.xfam.org/family/PF01497 Phobius swissprot:FHUD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FHUD_ECOLI PhylomeDB P07822 http://phylomedb.org/?seqid=P07822 ProteinModelPortal P07822 http://www.proteinmodelportal.org/query/uniprot/P07822 PubMed 10742172 http://www.ncbi.nlm.nih.gov/pubmed/10742172 PubMed 11805094 http://www.ncbi.nlm.nih.gov/pubmed/11805094 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17218314 http://www.ncbi.nlm.nih.gov/pubmed/17218314 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 2254301 http://www.ncbi.nlm.nih.gov/pubmed/2254301 PubMed 2823072 http://www.ncbi.nlm.nih.gov/pubmed/2823072 PubMed 3301821 http://www.ncbi.nlm.nih.gov/pubmed/3301821 PubMed 7651325 http://www.ncbi.nlm.nih.gov/pubmed/7651325 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 8522527 http://www.ncbi.nlm.nih.gov/pubmed/8522527 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9426146 http://www.ncbi.nlm.nih.gov/pubmed/9426146 RefSeq NP_414694 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414694 RefSeq WP_001310529 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001310529 SMR P07822 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P07822 STRING 511145.b0152 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0152&targetmode=cogs STRING COG0614 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0614&targetmode=cogs TCDB 3.A.1.14 http://www.tcdb.org/search/result.php?tc=3.A.1.14 UniProtKB FHUD_ECOLI http://www.uniprot.org/uniprot/FHUD_ECOLI UniProtKB-AC P07822 http://www.uniprot.org/uniprot/P07822 charge swissprot:FHUD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FHUD_ECOLI eggNOG COG0614 http://eggnogapi.embl.de/nog_data/html/tree/COG0614 eggNOG ENOG4105J76 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105J76 epestfind swissprot:FHUD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FHUD_ECOLI garnier swissprot:FHUD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FHUD_ECOLI helixturnhelix swissprot:FHUD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FHUD_ECOLI hmoment swissprot:FHUD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FHUD_ECOLI iep swissprot:FHUD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FHUD_ECOLI inforesidue swissprot:FHUD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FHUD_ECOLI octanol swissprot:FHUD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FHUD_ECOLI pepcoil swissprot:FHUD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FHUD_ECOLI pepdigest swissprot:FHUD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FHUD_ECOLI pepinfo swissprot:FHUD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FHUD_ECOLI pepnet swissprot:FHUD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FHUD_ECOLI pepstats swissprot:FHUD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FHUD_ECOLI pepwheel swissprot:FHUD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FHUD_ECOLI pepwindow swissprot:FHUD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FHUD_ECOLI sigcleave swissprot:FHUD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FHUD_ECOLI ## Database ID URL or Descriptions # AltName tRNA (uracil(54)-C(5))-methyltransferase {ECO:0000255|HAMAP-Rule MF_01011} # AltName tRNA(m5U54)-methyltransferase {ECO:0000255|HAMAP-Rule MF_01011} # AltName tmRNA (uracil(341)-C(5))-methyltransferase {ECO:0000255|HAMAP-Rule MF_01011} # BRENDA 2.1.1.35 2026 # CATALYTIC ACTIVITY TRMA_ECOLI S-adenosyl-L-methionine + uracil(341) in tmRNA = S-adenosyl-L-homocysteine + 5-methyluracil(341) in tmRNA. {ECO 0000255|HAMAP-Rule MF_01011, ECO 0000269|PubMed 23603891}. # CATALYTIC ACTIVITY TRMA_ECOLI S-adenosyl-L-methionine + uracil(54) in tRNA = S-adenosyl-L-homocysteine + 5-methyluracil(54) in tRNA. {ECO 0000255|HAMAP-Rule MF_01011, ECO 0000269|PubMed 23603891}. # DISRUPTION PHENOTYPE Cells lacking this gene exhibit a lack of m5U modification in tmRNA. {ECO:0000269|PubMed 23603891}. # EcoGene EG11022 trmA # FUNCTION TRMA_ECOLI Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA). {ECO 0000255|HAMAP-Rule MF_01011, ECO 0000269|PubMed 23603891, ECO 0000269|PubMed 2999071, ECO 0000269|PubMed 6247318}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000049 tRNA binding; IDA:EcoCyc. # GO_function GO:0019843 rRNA binding; IDA:EcoCyc. # GO_function GO:0030697 S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity; IDA:EcoCyc. # GO_process GO:0030488 tRNA methylation; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0008168 methyltransferase activity # GOslim_function GO:0019843 rRNA binding # GOslim_process GO:0006399 tRNA metabolic process # Gene3D 3.40.50.150 -; 1. # HAMAP MF_01011 RNA_methyltr_TrmA # INDUCTION TRMA_ECOLI Growth rate-dependent regulation of transcription. Is a novel example of a mRNA regulated through a mechanism similar to that of a stable RNA (rRNA). # IntAct P23003 5 # InterPro IPR010280 U5_MeTrfase_fam # InterPro IPR011869 TrmA_MeTrfase # InterPro IPR029063 SAM-dependent_MTases # InterPro IPR030390 MeTrfase_TrmA_AS # InterPro IPR030391 MeTrfase_TrmA_CS # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # Organism TRMA_ECOLI Escherichia coli (strain K12) # PATRIC 32123451 VBIEscCol129921_4086 # PDB 3BT7 X-ray; 2.43 A; A/B=1-366 # PIR A37321 A37321 # PROSITE PS01230 TRMA_1 # PROSITE PS01231 TRMA_2 # PROSITE PS51687 SAM_MT_RNA_M5U # Pfam PF05958 tRNA_U5-meth_tr # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName tRNA/tmRNA (uracil-C(5))-methyltransferase {ECO:0000255|HAMAP-Rule MF_01011} # RefSeq NP_418400 NC_000913.3 # RefSeq WP_000187022 NZ_LN832404.1 # SIMILARITY Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily. {ECO:0000255|HAMAP-Rule MF_01011}. # SUPFAM SSF53335 SSF53335 # TIGRFAMs TIGR02143 trmA_only # eggNOG COG2265 LUCA # eggNOG ENOG4107R9T Bacteria BLAST swissprot:TRMA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRMA_ECOLI BioCyc ECOL316407:JW3937-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3937-MONOMER BioCyc EcoCyc:EG11022-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11022-MONOMER BioCyc MetaCyc:EG11022-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11022-MONOMER COG COG2265 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2265 DIP DIP-11031N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11031N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0802247105 http://dx.doi.org/10.1073/pnas.0802247105 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.4161/rna.24327 http://dx.doi.org/10.4161/rna.24327 EC_number EC:2.1.1.- {ECO:0000255|HAMAP-Rule:MF_01011} http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.- {ECO:0000255|HAMAP-Rule:MF_01011} EC_number EC:2.1.1.35 {ECO:0000255|HAMAP-Rule:MF_01011} http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.35 {ECO:0000255|HAMAP-Rule:MF_01011} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M57568 http://www.ebi.ac.uk/ena/data/view/M57568 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X66026 http://www.ebi.ac.uk/ena/data/view/X66026 ENZYME 2.1.1.- {ECO:0000255|HAMAP-Rule:MF_01011} http://enzyme.expasy.org/EC/2.1.1.- {ECO:0000255|HAMAP-Rule:MF_01011} ENZYME 2.1.1.35 {ECO:0000255|HAMAP-Rule:MF_01011} http://enzyme.expasy.org/EC/2.1.1.35 {ECO:0000255|HAMAP-Rule:MF_01011} EchoBASE EB1015 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1015 EcoGene EG11022 http://www.ecogene.org/geneInfo.php?eg_id=EG11022 EnsemblBacteria AAC76947 http://www.ensemblgenomes.org/id/AAC76947 EnsemblBacteria AAC76947 http://www.ensemblgenomes.org/id/AAC76947 EnsemblBacteria BAE77346 http://www.ensemblgenomes.org/id/BAE77346 EnsemblBacteria BAE77346 http://www.ensemblgenomes.org/id/BAE77346 EnsemblBacteria BAE77346 http://www.ensemblgenomes.org/id/BAE77346 EnsemblBacteria b3965 http://www.ensemblgenomes.org/id/b3965 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000049 GO_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GO_function GO:0030697 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030697 GO_process GO:0030488 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030488 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 GeneID 947143 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947143 HAMAP MF_01011 http://hamap.expasy.org/unirule/MF_01011 HOGENOM HOG000218626 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218626&db=HOGENOM6 InParanoid P23003 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23003 IntAct P23003 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P23003* IntEnz 2.1.1.- {ECO:0000255|HAMAP-Rule:MF_01011} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.- {ECO:0000255|HAMAP-Rule:MF_01011} IntEnz 2.1.1.35 {ECO:0000255|HAMAP-Rule:MF_01011} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.35 {ECO:0000255|HAMAP-Rule:MF_01011} InterPro IPR010280 http://www.ebi.ac.uk/interpro/entry/IPR010280 InterPro IPR011869 http://www.ebi.ac.uk/interpro/entry/IPR011869 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 InterPro IPR030390 http://www.ebi.ac.uk/interpro/entry/IPR030390 InterPro IPR030391 http://www.ebi.ac.uk/interpro/entry/IPR030391 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW3937 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3937 KEGG_Gene eco:b3965 http://www.genome.jp/dbget-bin/www_bget?eco:b3965 KEGG_Orthology KO:K00557 http://www.genome.jp/dbget-bin/www_bget?KO:K00557 MINT MINT-1223595 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1223595 OMA ESAQYNI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ESAQYNI PDB 3BT7 http://www.ebi.ac.uk/pdbe-srv/view/entry/3BT7 PDBsum 3BT7 http://www.ebi.ac.uk/pdbsum/3BT7 PROSITE PS01230 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01230 PROSITE PS01231 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01231 PROSITE PS51687 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51687 PSORT swissprot:TRMA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRMA_ECOLI PSORT-B swissprot:TRMA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRMA_ECOLI PSORT2 swissprot:TRMA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRMA_ECOLI Pfam PF05958 http://pfam.xfam.org/family/PF05958 Phobius swissprot:TRMA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRMA_ECOLI PhylomeDB P23003 http://phylomedb.org/?seqid=P23003 ProteinModelPortal P23003 http://www.proteinmodelportal.org/query/uniprot/P23003 PubMed 1447162 http://www.ncbi.nlm.nih.gov/pubmed/1447162 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18451029 http://www.ncbi.nlm.nih.gov/pubmed/18451029 PubMed 1999392 http://www.ncbi.nlm.nih.gov/pubmed/1999392 PubMed 23603891 http://www.ncbi.nlm.nih.gov/pubmed/23603891 PubMed 2999071 http://www.ncbi.nlm.nih.gov/pubmed/2999071 PubMed 6247318 http://www.ncbi.nlm.nih.gov/pubmed/6247318 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_418400 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418400 RefSeq WP_000187022 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000187022 SMR P23003 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P23003 STRING 511145.b3965 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3965&targetmode=cogs STRING COG2265 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2265&targetmode=cogs SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 TIGRFAMs TIGR02143 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02143 UniProtKB TRMA_ECOLI http://www.uniprot.org/uniprot/TRMA_ECOLI UniProtKB-AC P23003 http://www.uniprot.org/uniprot/P23003 charge swissprot:TRMA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRMA_ECOLI eggNOG COG2265 http://eggnogapi.embl.de/nog_data/html/tree/COG2265 eggNOG ENOG4107R9T http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107R9T epestfind swissprot:TRMA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRMA_ECOLI garnier swissprot:TRMA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRMA_ECOLI helixturnhelix swissprot:TRMA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRMA_ECOLI hmoment swissprot:TRMA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRMA_ECOLI iep swissprot:TRMA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRMA_ECOLI inforesidue swissprot:TRMA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRMA_ECOLI octanol swissprot:TRMA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRMA_ECOLI pepcoil swissprot:TRMA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRMA_ECOLI pepdigest swissprot:TRMA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRMA_ECOLI pepinfo swissprot:TRMA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRMA_ECOLI pepnet swissprot:TRMA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRMA_ECOLI pepstats swissprot:TRMA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRMA_ECOLI pepwheel swissprot:TRMA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRMA_ECOLI pepwindow swissprot:TRMA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRMA_ECOLI sigcleave swissprot:TRMA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRMA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261510 9 # EcoGene EG13053 ygeW # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0004070 aspartate carbamoyltransferase activity; IEA:InterPro. # GO_function GO:0016597 amino acid binding; IEA:InterPro. # GO_process GO:0000050 urea cycle; IBA:GO_Central. # GO_process GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro. # GO_process GO:0006520 cellular amino acid metabolic process; IEA:InterPro. # GO_process GO:0044238 primary metabolic process; IBA:GO_Central. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0071941 nitrogen cycle metabolic process # Gene3D 3.40.50.1370 -; 2. # InterPro IPR002082 Asp_carbamoyltransf # InterPro IPR006130 Asp/Orn_carbamoylTrfase # InterPro IPR006131 Asp_carbamoyltransf_Asp/Orn-bd # InterPro IPR006132 Asp/Orn_carbamoyltranf_P-bd # InterPro IPR017702 Carbamoyltransferase_YgeW # Organism YGEW_ECOLI Escherichia coli (strain K12) # PATRIC 32121150 VBIEscCol129921_2963 # PDB 3Q98 X-ray; 2.00 A; A=1-396 # PIR F65070 F65070 # PRINTS PR00100 AOTCASE # PRINTS PR00101 ATCASE # Pfam PF00185 OTCace # Pfam PF02729 OTCace_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGEW_ECOLI Uncharacterized protein YgeW # RefSeq YP_026185 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA83051.1; Type=Frameshift; Positions=18, 373; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ATCase/OTCase family. {ECO 0000305}. # SUPFAM SSF53671 SSF53671 # TIGRFAMs TIGR03316 ygeW # eggNOG COG0078 LUCA # eggNOG ENOG4105IW6 Bacteria BLAST swissprot:YGEW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGEW_ECOLI BioCyc ECOL316407:JW5463-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5463-MONOMER BioCyc EcoCyc:G7489-MONOMER http://biocyc.org/getid?id=EcoCyc:G7489-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 EchoBASE EB2865 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2865 EcoGene EG13053 http://www.ecogene.org/geneInfo.php?eg_id=EG13053 EnsemblBacteria AAT48152 http://www.ensemblgenomes.org/id/AAT48152 EnsemblBacteria AAT48152 http://www.ensemblgenomes.org/id/AAT48152 EnsemblBacteria BAE76936 http://www.ensemblgenomes.org/id/BAE76936 EnsemblBacteria BAE76936 http://www.ensemblgenomes.org/id/BAE76936 EnsemblBacteria BAE76936 http://www.ensemblgenomes.org/id/BAE76936 EnsemblBacteria b2870 http://www.ensemblgenomes.org/id/b2870 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004070 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004070 GO_function GO:0016597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016597 GO_process GO:0000050 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000050 GO_process GO:0006207 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006207 GO_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GO_process GO:0044238 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044238 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0071941 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071941 Gene3D 3.40.50.1370 http://www.cathdb.info/version/latest/superfamily/3.40.50.1370 GeneID 945826 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945826 HOGENOM HOG000022686 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000022686&db=HOGENOM6 InParanoid Q46803 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46803 InterPro IPR002082 http://www.ebi.ac.uk/interpro/entry/IPR002082 InterPro IPR006130 http://www.ebi.ac.uk/interpro/entry/IPR006130 InterPro IPR006131 http://www.ebi.ac.uk/interpro/entry/IPR006131 InterPro IPR006132 http://www.ebi.ac.uk/interpro/entry/IPR006132 InterPro IPR017702 http://www.ebi.ac.uk/interpro/entry/IPR017702 KEGG_Gene ecj:JW5463 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5463 KEGG_Gene eco:b2870 http://www.genome.jp/dbget-bin/www_bget?eco:b2870 OMA WAPFAAM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WAPFAAM PDB 3Q98 http://www.ebi.ac.uk/pdbe-srv/view/entry/3Q98 PDBsum 3Q98 http://www.ebi.ac.uk/pdbsum/3Q98 PRINTS PR00100 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00100 PRINTS PR00101 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00101 PSORT swissprot:YGEW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGEW_ECOLI PSORT-B swissprot:YGEW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGEW_ECOLI PSORT2 swissprot:YGEW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGEW_ECOLI Pfam PF00185 http://pfam.xfam.org/family/PF00185 Pfam PF02729 http://pfam.xfam.org/family/PF02729 Phobius swissprot:YGEW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGEW_ECOLI PhylomeDB Q46803 http://phylomedb.org/?seqid=Q46803 ProteinModelPortal Q46803 http://www.proteinmodelportal.org/query/uniprot/Q46803 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq YP_026185 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026185 SMR Q46803 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46803 STRING 511145.b2870 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2870&targetmode=cogs SUPFAM SSF53671 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53671 TIGRFAMs TIGR03316 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03316 UniProtKB YGEW_ECOLI http://www.uniprot.org/uniprot/YGEW_ECOLI UniProtKB-AC Q46803 http://www.uniprot.org/uniprot/Q46803 charge swissprot:YGEW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGEW_ECOLI eggNOG COG0078 http://eggnogapi.embl.de/nog_data/html/tree/COG0078 eggNOG ENOG4105IW6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105IW6 epestfind swissprot:YGEW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGEW_ECOLI garnier swissprot:YGEW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGEW_ECOLI helixturnhelix swissprot:YGEW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGEW_ECOLI hmoment swissprot:YGEW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGEW_ECOLI iep swissprot:YGEW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGEW_ECOLI inforesidue swissprot:YGEW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGEW_ECOLI octanol swissprot:YGEW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGEW_ECOLI pepcoil swissprot:YGEW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGEW_ECOLI pepdigest swissprot:YGEW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGEW_ECOLI pepinfo swissprot:YGEW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGEW_ECOLI pepnet swissprot:YGEW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGEW_ECOLI pepstats swissprot:YGEW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGEW_ECOLI pepwheel swissprot:YGEW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGEW_ECOLI pepwindow swissprot:YGEW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGEW_ECOLI sigcleave swissprot:YGEW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGEW_ECOLI ## Database ID URL or Descriptions # AltName Sigma S {ECO:0000255|HAMAP-Rule MF_00959} # AltName Sigma-38 {ECO:0000255|HAMAP-Rule MF_00959} # BioGrid 4262274 303 # DISRUPTION PHENOTYPE Stationary phase cells lose resistance to killing by endoribonuclease MazF. {ECO:0000269|PubMed 19251848}. # DOMAIN RPOS_ECOLI The sigma-70 factor domain-2 mediates sequence-specific interaction with the -10 element in promoter DNA, and plays an important role in melting the double-stranded DNA and the formation of the transcription bubble. The sigma-70 factor domain- 2 mediates interaction with the RNA polymerase subunits RpoB and RpoC (By similarity). {ECO 0000250}. # DOMAIN RPOS_ECOLI The sigma-70 factor domain-4 contains a helix-turn-helix (H-T-H) motif that mediates interaction with the -35 element in promoter DNA. The domain also mediates interaction with the RNA polymerase subunit RpoA (By similarity). {ECO 0000250}. # EcoGene EG10510 rpoS # FUNCTION RPOS_ECOLI Protects stationary phase cells from killing induced by endoribonuclease MazF. {ECO 0000269|PubMed 19251848}. # FUNCTION RPOS_ECOLI Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. Controls, positively or negatively, the expression of several hundred genes, which are mainly involved in metabolism, transport, regulation and stress management. {ECO 0000255|HAMAP- Rule MF_00959, ECO 0000269|PubMed 15558318, ECO 0000269|PubMed 15716429, ECO 0000269|PubMed 16511888, ECO 0000269|PubMed 21398637, ECO 0000269|PubMed 8475100}. # GO_component GO:0005737 cytoplasm; IDA:EcoCyc. # GO_function GO:0001000 bacterial-type RNA polymerase core enzyme binding; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_function GO:0016987 sigma factor activity; IDA:EcoCyc. # GO_process GO:0001123 transcription initiation from bacterial-type RNA polymerase promoter; IDA:EcoCyc. # GO_process GO:0006950 response to stress; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0000988 transcription factor activity, protein binding # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0019899 enzyme binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 2. # HAMAP MF_00959 Sigma70_RpoS # INDUCTION RPOS_ECOLI Subject to complex regulation at multiple levels (transcription, translation, regulation of activity and degradation). Transcription is induced during entry into stationary phase and in response to different stresses. Transcription is repressed by antitoxin MqsA (PubMed 21516113). mRNA stability is regulated by small RNA regulators and various proteins such as Hfq, CsdA, CspC and CspE. Finally, the cellular level of RpoS is regulated by proteolysis via RssB and the ClpXP protease. {ECO 0000269|PubMed 10339606, ECO 0000269|PubMed 10672187, ECO 0000269|PubMed 21516113, ECO 0000269|PubMed 21639793, ECO 0000269|PubMed 8475100, ECO 0000269|PubMed 8637901}. # IntAct P13445 9 # InterPro IPR000943 RNA_pol_sigma70 # InterPro IPR007624 RNA_pol_sigma70_r3 # InterPro IPR007627 RNA_pol_sigma70_r2 # InterPro IPR007630 RNA_pol_sigma70_r4 # InterPro IPR009042 RNA_pol_sigma70_r1_2 # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR012761 RNA_pol_sigma_RpoS # InterPro IPR013324 RNA_pol_sigma_r3_r4 # InterPro IPR013325 RNA_pol_sigma_r2 # InterPro IPR014284 RNA_pol_sigma-70_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko03021 Transcription machinery # KEGG_Pathway ko05111 Vibrio cholerae pathogenic cycle # Organism RPOS_ECOLI Escherichia coli (strain K12) # PATRIC 32120886 VBIEscCol129921_2835 # PDB 5IPL X-ray; 3.60 A; F=1-328 # PDB 5IPM X-ray; 4.20 A; F=1-328 # PDB 5IPN X-ray; 4.61 A; F=1-328 # PIR A65055 RNECKF # PRINTS PR00046 SIGMA70FCT # PROSITE PS00715 SIGMA70_1 # PROSITE PS00716 SIGMA70_2 # Pfam PF00140 Sigma70_r1_2 # Pfam PF04539 Sigma70_r3 # Pfam PF04542 Sigma70_r2 # Pfam PF04545 Sigma70_r4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RNA polymerase sigma factor RpoS {ECO:0000255|HAMAP-Rule MF_00959} # RefSeq NP_417221 NC_000913.3 # RefSeq WP_000081588 NZ_CP014272.1 # SEQUENCE CAUTION Sequence=BAE76818.1; Type=Erroneous termination; Positions=33; Note=Translated as Gln.; Evidence={ECO:0000305}; Sequence=CAA34435.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=CAA78692.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; # SIMILARITY Belongs to the sigma-70 factor family. RpoS subfamily. {ECO:0000255|HAMAP-Rule MF_00959}. # SUBCELLULAR LOCATION RPOS_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00959}. # SUBUNIT RPOS_ECOLI Interacts with the RNA polymerase core enzyme and RssB. {ECO 0000255|HAMAP-Rule MF_00959, ECO 0000269|PubMed 10339606, ECO 0000269|PubMed 10672187}. # SUPFAM SSF88659 SSF88659; 2 # SUPFAM SSF88946 SSF88946 # TIGRFAMs TIGR02394 rpoS_proteo # TIGRFAMs TIGR02937 sigma70-ECF # eggNOG COG0568 LUCA # eggNOG ENOG4105DG1 Bacteria BLAST swissprot:RPOS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RPOS_ECOLI BioCyc ECOL316407:JW5437-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5437-MONOMER BioCyc EcoCyc:RPOS-MONOMER http://biocyc.org/getid?id=EcoCyc:RPOS-MONOMER BioCyc MetaCyc:RPOS-MONOMER http://biocyc.org/getid?id=MetaCyc:RPOS-MONOMER COG COG0568 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0568 DIP DIP-10777N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10777N DOI 10.1002/bit.20858 http://dx.doi.org/10.1002/bit.20858 DOI 10.1007/BF00284200 http://dx.doi.org/10.1007/BF00284200 DOI 10.1007/s00438-004-1089-2 http://dx.doi.org/10.1007/s00438-004-1089-2 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nchembio.560 http://dx.doi.org/10.1038/nchembio.560 DOI 10.1046/j.1365-2958.2000.01736.x http://dx.doi.org/10.1046/j.1365-2958.2000.01736.x DOI 10.1073/pnas.90.8.3511 http://dx.doi.org/10.1073/pnas.90.8.3511 DOI 10.1073/pnas.93.6.2488 http://dx.doi.org/10.1073/pnas.93.6.2488 DOI 10.1073/pnas.96.11.6439 http://dx.doi.org/10.1073/pnas.96.11.6439 DOI 10.1093/nar/17.23.9979 http://dx.doi.org/10.1093/nar/17.23.9979 DOI 10.1093/nar/20.20.5479 http://dx.doi.org/10.1093/nar/20.20.5479 DOI 10.1093/nar/gkr129 http://dx.doi.org/10.1093/nar/gkr129 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00011-09 http://dx.doi.org/10.1128/JB.00011-09 DOI 10.1128/JB.187.5.1591-1603.2005 http://dx.doi.org/10.1128/JB.187.5.1591-1603.2005 DOI 10.1146/annurev-micro-090110-102946 http://dx.doi.org/10.1146/annurev-micro-090110-102946 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D13548 http://www.ebi.ac.uk/ena/data/view/D13548 EMBL D17549 http://www.ebi.ac.uk/ena/data/view/D17549 EMBL L07869 http://www.ebi.ac.uk/ena/data/view/L07869 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EMBL X16400 http://www.ebi.ac.uk/ena/data/view/X16400 EMBL Z14969 http://www.ebi.ac.uk/ena/data/view/Z14969 EchoBASE EB0505 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0505 EcoGene EG10510 http://www.ecogene.org/geneInfo.php?eg_id=EG10510 EnsemblBacteria AAC75783 http://www.ensemblgenomes.org/id/AAC75783 EnsemblBacteria AAC75783 http://www.ensemblgenomes.org/id/AAC75783 EnsemblBacteria BAE76818 http://www.ensemblgenomes.org/id/BAE76818 EnsemblBacteria BAE76818 http://www.ensemblgenomes.org/id/BAE76818 EnsemblBacteria BAE76818 http://www.ensemblgenomes.org/id/BAE76818 EnsemblBacteria b2741 http://www.ensemblgenomes.org/id/b2741 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0001000 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001000 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0016987 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016987 GO_process GO:0001123 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001123 GO_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0000988 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000988 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0019899 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 947210 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947210 HAMAP MF_00959 http://hamap.expasy.org/unirule/MF_00959 HOGENOM HOG000270273 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000270273&db=HOGENOM6 InParanoid P13445 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P13445 IntAct P13445 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P13445* InterPro IPR000943 http://www.ebi.ac.uk/interpro/entry/IPR000943 InterPro IPR007624 http://www.ebi.ac.uk/interpro/entry/IPR007624 InterPro IPR007627 http://www.ebi.ac.uk/interpro/entry/IPR007627 InterPro IPR007630 http://www.ebi.ac.uk/interpro/entry/IPR007630 InterPro IPR009042 http://www.ebi.ac.uk/interpro/entry/IPR009042 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR012761 http://www.ebi.ac.uk/interpro/entry/IPR012761 InterPro IPR013324 http://www.ebi.ac.uk/interpro/entry/IPR013324 InterPro IPR013325 http://www.ebi.ac.uk/interpro/entry/IPR013325 InterPro IPR014284 http://www.ebi.ac.uk/interpro/entry/IPR014284 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko03021 http://www.genome.jp/dbget-bin/www_bget?ko03021 KEGG_Gene ecj:JW5437 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5437 KEGG_Gene eco:b2741 http://www.genome.jp/dbget-bin/www_bget?eco:b2741 KEGG_Orthology KO:K03087 http://www.genome.jp/dbget-bin/www_bget?KO:K03087 KEGG_Pathway ko05111 http://www.genome.jp/kegg-bin/show_pathway?ko05111 MINT MINT-1228474 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1228474 OMA KYIDYTR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KYIDYTR PDB 5IPL http://www.ebi.ac.uk/pdbe-srv/view/entry/5IPL PDB 5IPM http://www.ebi.ac.uk/pdbe-srv/view/entry/5IPM PDB 5IPN http://www.ebi.ac.uk/pdbe-srv/view/entry/5IPN PDBsum 5IPL http://www.ebi.ac.uk/pdbsum/5IPL PDBsum 5IPM http://www.ebi.ac.uk/pdbsum/5IPM PDBsum 5IPN http://www.ebi.ac.uk/pdbsum/5IPN PRINTS PR00046 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00046 PROSITE PS00715 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00715 PROSITE PS00716 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00716 PSORT swissprot:RPOS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RPOS_ECOLI PSORT-B swissprot:RPOS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RPOS_ECOLI PSORT2 swissprot:RPOS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RPOS_ECOLI Pfam PF00140 http://pfam.xfam.org/family/PF00140 Pfam PF04539 http://pfam.xfam.org/family/PF04539 Pfam PF04542 http://pfam.xfam.org/family/PF04542 Pfam PF04545 http://pfam.xfam.org/family/PF04545 Phobius swissprot:RPOS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RPOS_ECOLI PhylomeDB P13445 http://phylomedb.org/?seqid=P13445 ProteinModelPortal P13445 http://www.proteinmodelportal.org/query/uniprot/P13445 PubMed 10339606 http://www.ncbi.nlm.nih.gov/pubmed/10339606 PubMed 10672187 http://www.ncbi.nlm.nih.gov/pubmed/10672187 PubMed 1437569 http://www.ncbi.nlm.nih.gov/pubmed/1437569 PubMed 15558318 http://www.ncbi.nlm.nih.gov/pubmed/15558318 PubMed 15716429 http://www.ncbi.nlm.nih.gov/pubmed/15716429 PubMed 16511888 http://www.ncbi.nlm.nih.gov/pubmed/16511888 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19251848 http://www.ncbi.nlm.nih.gov/pubmed/19251848 PubMed 21398637 http://www.ncbi.nlm.nih.gov/pubmed/21398637 PubMed 21516113 http://www.ncbi.nlm.nih.gov/pubmed/21516113 PubMed 21639793 http://www.ncbi.nlm.nih.gov/pubmed/21639793 PubMed 2690013 http://www.ncbi.nlm.nih.gov/pubmed/2690013 PubMed 8132457 http://www.ncbi.nlm.nih.gov/pubmed/8132457 PubMed 8208244 http://www.ncbi.nlm.nih.gov/pubmed/8208244 PubMed 8475100 http://www.ncbi.nlm.nih.gov/pubmed/8475100 PubMed 8637901 http://www.ncbi.nlm.nih.gov/pubmed/8637901 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417221 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417221 RefSeq WP_000081588 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000081588 SMR P13445 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P13445 STRING 511145.b2741 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2741&targetmode=cogs STRING COG0568 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0568&targetmode=cogs SUPFAM SSF88659 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF88659 SUPFAM SSF88946 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF88946 TIGRFAMs TIGR02394 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02394 TIGRFAMs TIGR02937 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02937 UniProtKB RPOS_ECOLI http://www.uniprot.org/uniprot/RPOS_ECOLI UniProtKB-AC P13445 http://www.uniprot.org/uniprot/P13445 charge swissprot:RPOS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RPOS_ECOLI eggNOG COG0568 http://eggnogapi.embl.de/nog_data/html/tree/COG0568 eggNOG ENOG4105DG1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DG1 epestfind swissprot:RPOS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RPOS_ECOLI garnier swissprot:RPOS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RPOS_ECOLI helixturnhelix swissprot:RPOS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RPOS_ECOLI hmoment swissprot:RPOS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RPOS_ECOLI iep swissprot:RPOS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RPOS_ECOLI inforesidue swissprot:RPOS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RPOS_ECOLI octanol swissprot:RPOS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RPOS_ECOLI pepcoil swissprot:RPOS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RPOS_ECOLI pepdigest swissprot:RPOS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RPOS_ECOLI pepinfo swissprot:RPOS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RPOS_ECOLI pepnet swissprot:RPOS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RPOS_ECOLI pepstats swissprot:RPOS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RPOS_ECOLI pepwheel swissprot:RPOS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RPOS_ECOLI pepwindow swissprot:RPOS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RPOS_ECOLI sigcleave swissprot:RPOS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RPOS_ECOLI ## Database ID URL or Descriptions # AltName AROC_ECOLI 5-enolpyruvylshikimate-3-phosphate phospholyase {ECO 0000255|HAMAP-Rule MF_00300, ECO 0000303|PubMed 2969724} # BIOPHYSICOCHEMICAL PROPERTIES AROC_ECOLI Kinetic parameters KM=1.3 uM for EPSP {ECO 0000269|PubMed 7978236}; Vmax=25 umol/min/mg enzyme {ECO 0000269|PubMed 7978236}; Note=kcat is 16.5 sec(-1) for phospholyase activity with EPSP as substrate. kcat is 27 sec(-1) for phospholyase activity with EPSP as substrate. {ECO 0000269|PubMed 7848266, ECO 0000269|PubMed 7978236}; pH dependence Optimum pH is between 7.5 and 8. {ECO 0000269|PubMed 7978236}; # BioGrid 4263044 26 # CATALYTIC ACTIVITY AROC_ECOLI 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. {ECO 0000255|HAMAP-Rule MF_00300, ECO 0000269|PubMed 10956653, ECO 0000269|PubMed 11034781, ECO 0000269|PubMed 7848266, ECO 0000269|PubMed 7978236, ECO 0000269|PubMed 8703965}. # CDD cd07304 Chorismate_synthase # COFACTOR AROC_ECOLI Name=FMNH2; Xref=ChEBI CHEBI 57618; Evidence={ECO 0000255|HAMAP-Rule MF_00300, ECO 0000269|PubMed 10956653, ECO 0000269|PubMed 11034781, ECO 0000269|PubMed 2969724, ECO 0000269|PubMed 7978236, ECO 0000269|PubMed 8824216, ECO 0000269|PubMed 9761730}; Note=Reduced FMN (FMNH(2)). It can also use FAD, however FMN is the preferred cofactor. {ECO 0000255|HAMAP-Rule MF_00300, ECO 0000269|PubMed 10956653, ECO 0000269|PubMed 11034781, ECO 0000269|PubMed 2969724, ECO 0000269|PubMed 7978236, ECO 0000269|PubMed 8824216, ECO 0000269|PubMed 9761730}; # ENZYME REGULATION AROC_ECOLI Competitively inhibited by 6R-6-fluoro-EPSP. {ECO 0000269|PubMed 10956653, ECO 0000269|PubMed 7848266}. # EcoGene EG10075 aroC # FUNCTION AROC_ECOLI Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. It uses NADPH to reduce FMN. {ECO 0000255|HAMAP-Rule MF_00300, ECO 0000269|PubMed 10956653, ECO 0000269|PubMed 11034781, ECO 0000269|PubMed 2969724, ECO 0000269|PubMed 7848266, ECO 0000269|PubMed 7978236, ECO 0000269|PubMed 8703965}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004107 chorismate synthase activity; IDA:EcoCyc. # GO_function GO:0010181 FMN binding; IDA:UniProtKB. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0008652 cellular amino acid biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0009073 aromatic amino acid family biosynthetic process; IBA:GO_Central. # GO_process GO:0009423 chorismate biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.60.150.10 -; 1. # HAMAP MF_00300 Chorismate_synth # IntAct P12008 5 # InterPro IPR000453 Chorismate_synth # InterPro IPR020541 Chorismate_synthase_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis # Organism AROC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21085 PTHR21085 # PATHWAY Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. {ECO 0000255|HAMAP-Rule:MF_00300}. # PATRIC 32120031 VBIEscCol129921_2425 # PIR G65005 SYECKR # PIRSF PIRSF001456 Chorismate_synth # PROSITE PS00787 CHORISMATE_SYNTHASE_1 # PROSITE PS00788 CHORISMATE_SYNTHASE_2 # PROSITE PS00789 CHORISMATE_SYNTHASE_3 # Pfam PF01264 Chorismate_synt # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AROC_ECOLI Chorismate synthase {ECO 0000255|HAMAP-Rule MF_00300, ECO 0000303|PubMed 2969724} # RefSeq NP_416832 NC_000913.3 # RefSeq WP_001333535 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA23488.1; Type=Frameshift; Positions=335; Evidence={ECO 0000305}; # SIMILARITY Belongs to the chorismate synthase family. {ECO:0000255|HAMAP-Rule MF_00300, ECO:0000305}. # SUBUNIT AROC_ECOLI Homotetramer. {ECO 0000255|HAMAP-Rule MF_00300, ECO 0000269|PubMed 2969724, ECO 0000269|PubMed 9761730}. # SUPFAM SSF103263 SSF103263 # TIGRFAMs TIGR00033 aroC # UniPathway UPA00053 UER00090 # eggNOG COG0082 LUCA # eggNOG ENOG4105D10 Bacteria BLAST swissprot:AROC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AROC_ECOLI BioCyc ECOL316407:JW2326-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2326-MONOMER BioCyc EcoCyc:AROC-MONOMER http://biocyc.org/getid?id=EcoCyc:AROC-MONOMER BioCyc MetaCyc:AROC-MONOMER http://biocyc.org/getid?id=MetaCyc:AROC-MONOMER COG COG0082 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0082 DOI 10.1006/abio.1994.1309 http://dx.doi.org/10.1006/abio.1994.1309 DOI 10.1006/bioo.2000.1174 http://dx.doi.org/10.1006/bioo.2000.1174 DOI 10.1021/bi952958q http://dx.doi.org/10.1021/bi952958q DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2510313 http://dx.doi.org/10.1042/bj2510313 DOI 10.1042/bj3050707 http://dx.doi.org/10.1042/bj3050707 DOI 10.1042/bj3350319 http://dx.doi.org/10.1042/bj3350319 DOI 10.1074/jbc.271.42.25850 http://dx.doi.org/10.1074/jbc.271.42.25850 DOI 10.1074/jbc.M005796200 http://dx.doi.org/10.1074/jbc.M005796200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1099/00221287-136-2-353 http://dx.doi.org/10.1099/00221287-136-2-353 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.3.5 {ECO:0000255|HAMAP-Rule:MF_00300, ECO:0000269|PubMed:10956653, ECO:0000269|PubMed:11034781, ECO:0000269|PubMed:7848266, ECO:0000269|PubMed:7978236, ECO:0000269|PubMed:8703965} http://www.genome.jp/dbget-bin/www_bget?EC:4.2.3.5 {ECO:0000255|HAMAP-Rule:MF_00300, ECO:0000269|PubMed:10956653, ECO:0000269|PubMed:11034781, ECO:0000269|PubMed:7848266, ECO:0000269|PubMed:7978236, ECO:0000269|PubMed:8703965} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M27714 http://www.ebi.ac.uk/ena/data/view/M27714 EMBL M33021 http://www.ebi.ac.uk/ena/data/view/M33021 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL Y00720 http://www.ebi.ac.uk/ena/data/view/Y00720 ENZYME 4.2.3.5 {ECO:0000255|HAMAP-Rule:MF_00300, ECO:0000269|PubMed:10956653, ECO:0000269|PubMed:11034781, ECO:0000269|PubMed:7848266, ECO:0000269|PubMed:7978236, ECO:0000269|PubMed:8703965} http://enzyme.expasy.org/EC/4.2.3.5 {ECO:0000255|HAMAP-Rule:MF_00300, ECO:0000269|PubMed:10956653, ECO:0000269|PubMed:11034781, ECO:0000269|PubMed:7848266, ECO:0000269|PubMed:7978236, ECO:0000269|PubMed:8703965} EchoBASE EB0073 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0073 EcoGene EG10075 http://www.ecogene.org/geneInfo.php?eg_id=EG10075 EnsemblBacteria AAC75389 http://www.ensemblgenomes.org/id/AAC75389 EnsemblBacteria AAC75389 http://www.ensemblgenomes.org/id/AAC75389 EnsemblBacteria BAA16185 http://www.ensemblgenomes.org/id/BAA16185 EnsemblBacteria BAA16185 http://www.ensemblgenomes.org/id/BAA16185 EnsemblBacteria BAA16185 http://www.ensemblgenomes.org/id/BAA16185 EnsemblBacteria b2329 http://www.ensemblgenomes.org/id/b2329 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004107 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004107 GO_function GO:0010181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010181 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0008652 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008652 GO_process GO:0009073 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009073 GO_process GO:0009423 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009423 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.60.150.10 http://www.cathdb.info/version/latest/superfamily/3.60.150.10 GeneID 946814 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946814 HAMAP MF_00300 http://hamap.expasy.org/unirule/MF_00300 HOGENOM HOG000060335 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000060335&db=HOGENOM6 InParanoid P12008 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P12008 IntAct P12008 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P12008* IntEnz 4.2.3.5 {ECO:0000255|HAMAP-Rule:MF_00300, ECO:0000269|PubMed:10956653, ECO:0000269|PubMed:11034781, ECO:0000269|PubMed:7848266, ECO:0000269|PubMed:7978236, ECO:0000269|PubMed:8703965} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.3.5 {ECO:0000255|HAMAP-Rule:MF_00300, ECO:0000269|PubMed:10956653, ECO:0000269|PubMed:11034781, ECO:0000269|PubMed:7848266, ECO:0000269|PubMed:7978236, ECO:0000269|PubMed:8703965} InterPro IPR000453 http://www.ebi.ac.uk/interpro/entry/IPR000453 InterPro IPR020541 http://www.ebi.ac.uk/interpro/entry/IPR020541 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2326 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2326 KEGG_Gene eco:b2329 http://www.genome.jp/dbget-bin/www_bget?eco:b2329 KEGG_Orthology KO:K01736 http://www.genome.jp/dbget-bin/www_bget?KO:K01736 KEGG_Pathway ko00400 http://www.genome.jp/kegg-bin/show_pathway?ko00400 KEGG_Reaction rn:R01714 http://www.genome.jp/dbget-bin/www_bget?rn:R01714 OMA MLSINAV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MLSINAV PANTHER PTHR21085 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21085 PROSITE PS00787 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00787 PROSITE PS00788 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00788 PROSITE PS00789 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00789 PSORT swissprot:AROC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AROC_ECOLI PSORT-B swissprot:AROC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AROC_ECOLI PSORT2 swissprot:AROC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AROC_ECOLI Pfam PF01264 http://pfam.xfam.org/family/PF01264 Phobius swissprot:AROC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AROC_ECOLI PhylomeDB P12008 http://phylomedb.org/?seqid=P12008 ProteinModelPortal P12008 http://www.proteinmodelportal.org/query/uniprot/P12008 PubMed 10956653 http://www.ncbi.nlm.nih.gov/pubmed/10956653 PubMed 11034781 http://www.ncbi.nlm.nih.gov/pubmed/11034781 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2182772 http://www.ncbi.nlm.nih.gov/pubmed/2182772 PubMed 2969724 http://www.ncbi.nlm.nih.gov/pubmed/2969724 PubMed 7848266 http://www.ncbi.nlm.nih.gov/pubmed/7848266 PubMed 7978236 http://www.ncbi.nlm.nih.gov/pubmed/7978236 PubMed 8703965 http://www.ncbi.nlm.nih.gov/pubmed/8703965 PubMed 8824216 http://www.ncbi.nlm.nih.gov/pubmed/8824216 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9761730 http://www.ncbi.nlm.nih.gov/pubmed/9761730 RefSeq NP_416832 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416832 RefSeq WP_001333535 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001333535 SMR P12008 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P12008 STRING 511145.b2329 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2329&targetmode=cogs STRING COG0082 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0082&targetmode=cogs SUPFAM SSF103263 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103263 TIGRFAMs TIGR00033 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00033 UniProtKB AROC_ECOLI http://www.uniprot.org/uniprot/AROC_ECOLI UniProtKB-AC P12008 http://www.uniprot.org/uniprot/P12008 charge swissprot:AROC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AROC_ECOLI eggNOG COG0082 http://eggnogapi.embl.de/nog_data/html/tree/COG0082 eggNOG ENOG4105D10 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D10 epestfind swissprot:AROC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AROC_ECOLI garnier swissprot:AROC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AROC_ECOLI helixturnhelix swissprot:AROC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AROC_ECOLI hmoment swissprot:AROC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AROC_ECOLI iep swissprot:AROC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AROC_ECOLI inforesidue swissprot:AROC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AROC_ECOLI octanol swissprot:AROC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AROC_ECOLI pepcoil swissprot:AROC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AROC_ECOLI pepdigest swissprot:AROC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AROC_ECOLI pepinfo swissprot:AROC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AROC_ECOLI pepnet swissprot:AROC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AROC_ECOLI pepstats swissprot:AROC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AROC_ECOLI pepwheel swissprot:AROC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AROC_ECOLI pepwindow swissprot:AROC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AROC_ECOLI sigcleave swissprot:AROC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AROC_ECOLI ## Database ID URL or Descriptions # BioGrid 4261323 8 # EcoGene EG12235 arsR # FUNCTION ARSR_ECOLI Transcriptional repressor for the arsEFG operon. ArsE is a trans-acting regulatory protein which controls its own expression. The repressive effect of ArsE is alleviated by oxyions of +III oxidation state of arsenic, antimony, and bismuth, as well as arsenate (As(V)) (By similarity). {ECO 0000250}. # GO_component GO:0005622 intracellular; IEA:InterPro. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; EXP:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0046685 response to arsenic-containing substance; IDA:EcoCyc. # GOslim_component GO:0005622 intracellular # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # IntAct P37309 3 # InterPro IPR001845 HTH_ArsR_DNA-bd_dom # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR018334 ArsR_HTH # KEGG_Brite ko03000 Transcription factors # Organism ARSR_ECOLI Escherichia coli (strain K12) # PATRIC 32122456 VBIEscCol129921_3605 # PIR A56269 A56269 # PRINTS PR00778 HTHARSR # PROSITE PS00846 HTH_ARSR_1 # PROSITE PS50987 HTH_ARSR_2 # Pfam PF01022 HTH_5 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ARSR_ECOLI Arsenical resistance operon repressor # RefSeq NP_417958 NC_000913.3 # RefSeq WP_000008957 NZ_LN832404.1 # SIMILARITY Contains 1 HTH arsR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00340}. # SMART SM00418 HTH_ARSR # SUBUNIT Binds DNA as a homodimer. {ECO 0000250}. # SUPFAM SSF46785 SSF46785 # eggNOG COG0640 LUCA # eggNOG ENOG4105KBH Bacteria BLAST swissprot:ARSR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARSR_ECOLI BioCyc ECOL316407:JW3468-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3468-MONOMER BioCyc EcoCyc:EG12235-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12235-MONOMER BioCyc MetaCyc:EG12235-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12235-MONOMER COG COG0640 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0640 DIP DIP-9163N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9163N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X80057 http://www.ebi.ac.uk/ena/data/view/X80057 EchoBASE EB2147 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2147 EcoGene EG12235 http://www.ecogene.org/geneInfo.php?eg_id=EG12235 EnsemblBacteria AAC76526 http://www.ensemblgenomes.org/id/AAC76526 EnsemblBacteria AAC76526 http://www.ensemblgenomes.org/id/AAC76526 EnsemblBacteria BAE77793 http://www.ensemblgenomes.org/id/BAE77793 EnsemblBacteria BAE77793 http://www.ensemblgenomes.org/id/BAE77793 EnsemblBacteria BAE77793 http://www.ensemblgenomes.org/id/BAE77793 EnsemblBacteria b3501 http://www.ensemblgenomes.org/id/b3501 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0046685 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046685 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 948013 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948013 HOGENOM HOG000144506 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000144506&db=HOGENOM6 InParanoid P37309 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37309 IntAct P37309 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37309* InterPro IPR001845 http://www.ebi.ac.uk/interpro/entry/IPR001845 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR018334 http://www.ebi.ac.uk/interpro/entry/IPR018334 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW3468 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3468 KEGG_Gene eco:b3501 http://www.genome.jp/dbget-bin/www_bget?eco:b3501 KEGG_Orthology KO:K03892 http://www.genome.jp/dbget-bin/www_bget?KO:K03892 MINT MINT-1525524 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1525524 OMA WVYYELS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WVYYELS PRINTS PR00778 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00778 PROSITE PS00846 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00846 PROSITE PS50987 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50987 PSORT swissprot:ARSR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARSR_ECOLI PSORT-B swissprot:ARSR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARSR_ECOLI PSORT2 swissprot:ARSR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARSR_ECOLI Pfam PF01022 http://pfam.xfam.org/family/PF01022 Phobius swissprot:ARSR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARSR_ECOLI PhylomeDB P37309 http://phylomedb.org/?seqid=P37309 ProteinModelPortal P37309 http://www.proteinmodelportal.org/query/uniprot/P37309 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7721697 http://www.ncbi.nlm.nih.gov/pubmed/7721697 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417958 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417958 RefSeq WP_000008957 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000008957 SMART SM00418 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00418 SMR P37309 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37309 STRING 511145.b3501 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3501&targetmode=cogs STRING COG0640 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0640&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB ARSR_ECOLI http://www.uniprot.org/uniprot/ARSR_ECOLI UniProtKB-AC P37309 http://www.uniprot.org/uniprot/P37309 charge swissprot:ARSR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARSR_ECOLI eggNOG COG0640 http://eggnogapi.embl.de/nog_data/html/tree/COG0640 eggNOG ENOG4105KBH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KBH epestfind swissprot:ARSR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARSR_ECOLI garnier swissprot:ARSR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARSR_ECOLI helixturnhelix swissprot:ARSR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARSR_ECOLI hmoment swissprot:ARSR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARSR_ECOLI iep swissprot:ARSR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARSR_ECOLI inforesidue swissprot:ARSR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARSR_ECOLI octanol swissprot:ARSR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARSR_ECOLI pepcoil swissprot:ARSR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARSR_ECOLI pepdigest swissprot:ARSR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARSR_ECOLI pepinfo swissprot:ARSR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARSR_ECOLI pepnet swissprot:ARSR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARSR_ECOLI pepstats swissprot:ARSR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARSR_ECOLI pepwheel swissprot:ARSR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARSR_ECOLI pepwindow swissprot:ARSR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARSR_ECOLI sigcleave swissprot:ARSR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARSR_ECOLI ## Database ID URL or Descriptions # AltName ARNA_ECOLI ArnADH # AltName ARNA_ECOLI ArnAFT # AltName ARNA_ECOLI Polymyxin resistance protein PmrI # AltName ARNA_ECOLI Polymyxin resistance protein PmrI # AltName ARNA_ECOLI UDP-GlcUA decarboxylase # AltName ARNA_ECOLI UDP-L-Ara4N formyltransferase # AltName ARNA_ECOLI UDP-L-Ara4N formyltransferase # AltName ARNA_ECOLI UDP-glucuronic acid dehydrogenase # BIOPHYSICOCHEMICAL PROPERTIES ARNA_ECOLI Kinetic parameters KM=0.76 mM for NAD {ECO 0000269|PubMed 15491143}; KM=0.086 mM for UDP-GlcUA {ECO 0000269|PubMed 15491143}; # BRENDA 1.1.1.305 2026 # BRENDA 2.1.2.13 2026 # BioGrid 4260497 240 # CATALYTIC ACTIVITY ARNA_ECOLI 10-formyltetrahydrofolate + UDP-4-amino-4- deoxy-beta-L-arabinose = 5,6,7,8-tetrahydrofolate + UDP-4-deoxy-4- formamido-beta-L-arabinose. # CATALYTIC ACTIVITY ARNA_ECOLI UDP-alpha-D-glucuronate + NAD(+) = UDP-beta-L- threo-pentapyranos-4-ulose + CO(2) + NADH. # EcoGene EG14091 arnA # FUNCTION ARNA_ECOLI Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. {ECO 0000269|PubMed 11706007, ECO 0000269|PubMed 15695810}. # GO_function GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IDA:EcoCyc. # GO_function GO:0016742 hydroxymethyl-, formyl- and related transferase activity; IDA:EcoCyc. # GO_function GO:0048040 UDP-glucuronate decarboxylase activity; IDA:UniProtKB. # GO_function GO:0070403 NAD+ binding; IDA:UniProtKB. # GO_function GO:0099618 UDP-glucuronic acid dehydrogenase activity; IEA:UniProtKB-EC. # GO_function GO:0099619 UDP-4-amino-4-deoxy-L-arabinose formyltransferase activity; IEA:UniProtKB-EC. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0009245 lipid A biosynthetic process; IDA:EcoCyc. # GO_process GO:0033320 UDP-D-xylose biosynthetic process; IDA:UniProtKB. # GO_process GO:0046677 response to antibiotic; IDA:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.10.25.10 -; 1. # Gene3D 3.40.50.170 -; 1. # Gene3D 3.40.50.720 -; 1. # HAMAP MF_01166 ArnA # INDUCTION Induced by BasR. {ECO:0000269|PubMed 15569938}. # IntAct P77398 14 # InterPro IPR001509 Epimerase_deHydtase # InterPro IPR002376 Formyl_transf_N # InterPro IPR005793 Formyl_trans_C # InterPro IPR011034 Formyl_transferase_C-like # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR021168 Bifun_polymyxin_resist_ArnA # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # KEGG_Pathway ko00520 Amino sugar and nucleotide sugar metabolism # Organism ARNA_ECOLI Escherichia coli (strain K12) # PATHWAY Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. {ECO:0000269|PubMed 17928292}. # PATHWAY Nucleotide-sugar biosynthesis; UDP-4-deoxy-4-formamido- beta-L-arabinose biosynthesis; UDP-4-deoxy-4-formamido-beta-L- arabinose from UDP-alpha-D-glucuronate: step 1/3. {ECO 0000269|PubMed:17928292}. # PATHWAY Nucleotide-sugar biosynthesis; UDP-4-deoxy-4-formamido- beta-L-arabinose biosynthesis; UDP-4-deoxy-4-formamido-beta-L- arabinose from UDP-alpha-D-glucuronate: step 3/3. {ECO 0000269|PubMed:17928292}. # PATRIC 32119875 VBIEscCol129921_2347 # PDB 1U9J X-ray; 2.40 A; A=306-660 # PDB 1YRW X-ray; 1.70 A; A=1-300 # PDB 1Z73 X-ray; 2.50 A; A=306-660 # PDB 1Z74 X-ray; 2.70 A; A=306-660 # PDB 1Z75 X-ray; 2.40 A; A=306-660 # PDB 1Z7B X-ray; 2.31 A; A=306-660 # PDB 1Z7E X-ray; 3.00 A; A/B/C/D/E/F=1-660 # PDB 2BLL X-ray; 2.30 A; A=317-660 # PDB 2BLN X-ray; 1.20 A; A/B=1-305 # PDB 4WKG X-ray; 2.70 A; A/B/C/D/E/F=1-660 # PIR E64996 E64996 # PIRSF PIRSF036506 Bifun_polymyxin_resist_ArnA # Pfam PF00551 Formyl_trans_N # Pfam PF01370 Epimerase # Pfam PF02911 Formyl_trans_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ARNA_ECOLI Bifunctional polymyxin resistance protein ArnA # RecName ARNA_ECOLI UDP-4-amino-4-deoxy-L-arabinose formyltransferase # RecName ARNA_ECOLI UDP-glucuronic acid oxidase, UDP-4-keto-hexauronic acid decarboxylating # RefSeq NP_416758 NC_000913.3 # RefSeq WP_000860273 NZ_LN832404.1 # SIMILARITY In the C-terminal section; belongs to the NAD(P)- dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily. {ECO 0000305}. # SIMILARITY In the N-terminal section; belongs to the Fmt family. UDP-L-Ara4N formyltransferase subfamily. {ECO 0000305}. # SUBUNIT ARNA_ECOLI Homohexamer, formed by a dimer of trimers. {ECO 0000269|PubMed 15809294, ECO 0000269|PubMed 15939024}. # SUPFAM SSF50486 SSF50486 # SUPFAM SSF51735 SSF51735 # SUPFAM SSF53328 SSF53328 # UniPathway UPA00032 UER00492 # UniPathway UPA00032 UER00494 # eggNOG COG0223 LUCA # eggNOG COG0451 LUCA # eggNOG ENOG4105C3I Bacteria BLAST swissprot:ARNA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARNA_ECOLI BioCyc ECOL316407:JW2249-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2249-MONOMER BioCyc EcoCyc:G7168-MONOMER http://biocyc.org/getid?id=EcoCyc:G7168-MONOMER BioCyc MetaCyc:G7168-MONOMER http://biocyc.org/getid?id=MetaCyc:G7168-MONOMER DIP DIP-11961N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11961N DOI 10.1016/j.str.2005.03.018 http://dx.doi.org/10.1016/j.str.2005.03.018 DOI 10.1021/bi047384g http://dx.doi.org/10.1021/bi047384g DOI 10.1021/bi048551f http://dx.doi.org/10.1021/bi048551f DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0406038101 http://dx.doi.org/10.1073/pnas.0406038101 DOI 10.1074/jbc.M109377200 http://dx.doi.org/10.1074/jbc.M109377200 DOI 10.1074/jbc.M414265200 http://dx.doi.org/10.1074/jbc.M414265200 DOI 10.1074/jbc.M501534200 http://dx.doi.org/10.1074/jbc.M501534200 DOI 10.1074/jbc.M706172200 http://dx.doi.org/10.1074/jbc.M706172200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.305 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.305 EC_number EC:2.1.2.13 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.2.13 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL AY057445 http://www.ebi.ac.uk/ena/data/view/AY057445 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.1.1.305 http://enzyme.expasy.org/EC/1.1.1.305 ENZYME 2.1.2.13 http://enzyme.expasy.org/EC/2.1.2.13 EchoBASE EB3844 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3844 EcoGene EG14091 http://www.ecogene.org/geneInfo.php?eg_id=EG14091 EnsemblBacteria AAC75315 http://www.ensemblgenomes.org/id/AAC75315 EnsemblBacteria AAC75315 http://www.ensemblgenomes.org/id/AAC75315 EnsemblBacteria BAA16078 http://www.ensemblgenomes.org/id/BAA16078 EnsemblBacteria BAA16078 http://www.ensemblgenomes.org/id/BAA16078 EnsemblBacteria BAA16078 http://www.ensemblgenomes.org/id/BAA16078 EnsemblBacteria b2255 http://www.ensemblgenomes.org/id/b2255 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016616 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016616 GO_function GO:0016742 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016742 GO_function GO:0048040 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048040 GO_function GO:0070403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070403 GO_function GO:0099618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0099618 GO_function GO:0099619 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0099619 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GO_process GO:0009245 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009245 GO_process GO:0033320 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033320 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.10.25.10 http://www.cathdb.info/version/latest/superfamily/3.10.25.10 Gene3D 3.40.50.170 http://www.cathdb.info/version/latest/superfamily/3.40.50.170 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 947683 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947683 HAMAP MF_01166 http://hamap.expasy.org/unirule/MF_01166 HOGENOM HOG000247761 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000247761&db=HOGENOM6 InParanoid P77398 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77398 IntAct P77398 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77398* IntEnz 1.1.1.305 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.305 IntEnz 2.1.2.13 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.2.13 InterPro IPR001509 http://www.ebi.ac.uk/interpro/entry/IPR001509 InterPro IPR002376 http://www.ebi.ac.uk/interpro/entry/IPR002376 InterPro IPR005793 http://www.ebi.ac.uk/interpro/entry/IPR005793 InterPro IPR011034 http://www.ebi.ac.uk/interpro/entry/IPR011034 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR021168 http://www.ebi.ac.uk/interpro/entry/IPR021168 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Gene ecj:JW2249 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2249 KEGG_Gene eco:b2255 http://www.genome.jp/dbget-bin/www_bget?eco:b2255 KEGG_Orthology KO:K10011 http://www.genome.jp/dbget-bin/www_bget?KO:K10011 KEGG_Pathway ko00520 http://www.genome.jp/kegg-bin/show_pathway?ko00520 KEGG_Reaction rn:R07658 http://www.genome.jp/dbget-bin/www_bget?rn:R07658 KEGG_Reaction rn:R07660 http://www.genome.jp/dbget-bin/www_bget?rn:R07660 MINT MINT-1257581 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1257581 OMA VRYCVKY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VRYCVKY PDB 1U9J http://www.ebi.ac.uk/pdbe-srv/view/entry/1U9J PDB 1YRW http://www.ebi.ac.uk/pdbe-srv/view/entry/1YRW PDB 1Z73 http://www.ebi.ac.uk/pdbe-srv/view/entry/1Z73 PDB 1Z74 http://www.ebi.ac.uk/pdbe-srv/view/entry/1Z74 PDB 1Z75 http://www.ebi.ac.uk/pdbe-srv/view/entry/1Z75 PDB 1Z7B http://www.ebi.ac.uk/pdbe-srv/view/entry/1Z7B PDB 1Z7E http://www.ebi.ac.uk/pdbe-srv/view/entry/1Z7E PDB 2BLL http://www.ebi.ac.uk/pdbe-srv/view/entry/2BLL PDB 2BLN http://www.ebi.ac.uk/pdbe-srv/view/entry/2BLN PDB 4WKG http://www.ebi.ac.uk/pdbe-srv/view/entry/4WKG PDBsum 1U9J http://www.ebi.ac.uk/pdbsum/1U9J PDBsum 1YRW http://www.ebi.ac.uk/pdbsum/1YRW PDBsum 1Z73 http://www.ebi.ac.uk/pdbsum/1Z73 PDBsum 1Z74 http://www.ebi.ac.uk/pdbsum/1Z74 PDBsum 1Z75 http://www.ebi.ac.uk/pdbsum/1Z75 PDBsum 1Z7B http://www.ebi.ac.uk/pdbsum/1Z7B PDBsum 1Z7E http://www.ebi.ac.uk/pdbsum/1Z7E PDBsum 2BLL http://www.ebi.ac.uk/pdbsum/2BLL PDBsum 2BLN http://www.ebi.ac.uk/pdbsum/2BLN PDBsum 4WKG http://www.ebi.ac.uk/pdbsum/4WKG PSORT swissprot:ARNA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARNA_ECOLI PSORT-B swissprot:ARNA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARNA_ECOLI PSORT2 swissprot:ARNA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARNA_ECOLI Pfam PF00551 http://pfam.xfam.org/family/PF00551 Pfam PF01370 http://pfam.xfam.org/family/PF01370 Pfam PF02911 http://pfam.xfam.org/family/PF02911 Phobius swissprot:ARNA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARNA_ECOLI PhylomeDB P77398 http://phylomedb.org/?seqid=P77398 ProteinModelPortal P77398 http://www.proteinmodelportal.org/query/uniprot/P77398 PubMed 11706007 http://www.ncbi.nlm.nih.gov/pubmed/11706007 PubMed 15491143 http://www.ncbi.nlm.nih.gov/pubmed/15491143 PubMed 15569938 http://www.ncbi.nlm.nih.gov/pubmed/15569938 PubMed 15695810 http://www.ncbi.nlm.nih.gov/pubmed/15695810 PubMed 15807526 http://www.ncbi.nlm.nih.gov/pubmed/15807526 PubMed 15809294 http://www.ncbi.nlm.nih.gov/pubmed/15809294 PubMed 15939024 http://www.ncbi.nlm.nih.gov/pubmed/15939024 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17928292 http://www.ncbi.nlm.nih.gov/pubmed/17928292 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416758 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416758 RefSeq WP_000860273 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000860273 SMR P77398 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77398 STRING 511145.b2255 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2255&targetmode=cogs SUPFAM SSF50486 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50486 SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 SUPFAM SSF53328 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53328 UniProtKB ARNA_ECOLI http://www.uniprot.org/uniprot/ARNA_ECOLI UniProtKB-AC P77398 http://www.uniprot.org/uniprot/P77398 charge swissprot:ARNA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARNA_ECOLI eggNOG COG0223 http://eggnogapi.embl.de/nog_data/html/tree/COG0223 eggNOG COG0451 http://eggnogapi.embl.de/nog_data/html/tree/COG0451 eggNOG ENOG4105C3I http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C3I epestfind swissprot:ARNA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARNA_ECOLI garnier swissprot:ARNA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARNA_ECOLI helixturnhelix swissprot:ARNA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARNA_ECOLI hmoment swissprot:ARNA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARNA_ECOLI iep swissprot:ARNA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARNA_ECOLI inforesidue swissprot:ARNA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARNA_ECOLI octanol swissprot:ARNA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARNA_ECOLI pepcoil swissprot:ARNA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARNA_ECOLI pepdigest swissprot:ARNA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARNA_ECOLI pepinfo swissprot:ARNA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARNA_ECOLI pepnet swissprot:ARNA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARNA_ECOLI pepstats swissprot:ARNA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARNA_ECOLI pepwheel swissprot:ARNA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARNA_ECOLI pepwindow swissprot:ARNA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARNA_ECOLI sigcleave swissprot:ARNA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARNA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260371 17 # EcoGene EG14036 yecR # InterPro IPR025731 YecR-like # Organism YECR_ECOLI Escherichia coli (strain K12) # PATRIC 32119135 VBIEscCol129921_1985 # PIR H64953 H64953 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF13992 YecR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YECR_ECOLI Uncharacterized protein YecR # RefSeq NP_416417 NC_000913.3 # RefSeq WP_001237869 NZ_LN832404.1 # eggNOG ENOG4105P23 Bacteria # eggNOG ENOG41121GA LUCA BLAST swissprot:YECR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YECR_ECOLI BioCyc ECOL316407:JW1892-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1892-MONOMER BioCyc EcoCyc:G7035-MONOMER http://biocyc.org/getid?id=EcoCyc:G7035-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3790 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3790 EcoGene EG14036 http://www.ecogene.org/geneInfo.php?eg_id=EG14036 EnsemblBacteria AAC74974 http://www.ensemblgenomes.org/id/AAC74974 EnsemblBacteria AAC74974 http://www.ensemblgenomes.org/id/AAC74974 EnsemblBacteria BAE76550 http://www.ensemblgenomes.org/id/BAE76550 EnsemblBacteria BAE76550 http://www.ensemblgenomes.org/id/BAE76550 EnsemblBacteria BAE76550 http://www.ensemblgenomes.org/id/BAE76550 EnsemblBacteria b1904 http://www.ensemblgenomes.org/id/b1904 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946386 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946386 HOGENOM HOG000121263 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000121263&db=HOGENOM6 InterPro IPR025731 http://www.ebi.ac.uk/interpro/entry/IPR025731 KEGG_Gene ecj:JW1892 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1892 KEGG_Gene eco:b1904 http://www.genome.jp/dbget-bin/www_bget?eco:b1904 OMA QAMLQNA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QAMLQNA PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YECR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YECR_ECOLI PSORT-B swissprot:YECR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YECR_ECOLI PSORT2 swissprot:YECR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YECR_ECOLI Pfam PF13992 http://pfam.xfam.org/family/PF13992 Phobius swissprot:YECR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YECR_ECOLI ProteinModelPortal P76308 http://www.proteinmodelportal.org/query/uniprot/P76308 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416417 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416417 RefSeq WP_001237869 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001237869 STRING 511145.b1904 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1904&targetmode=cogs UniProtKB YECR_ECOLI http://www.uniprot.org/uniprot/YECR_ECOLI UniProtKB-AC P76308 http://www.uniprot.org/uniprot/P76308 charge swissprot:YECR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YECR_ECOLI eggNOG ENOG4105P23 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105P23 eggNOG ENOG41121GA http://eggnogapi.embl.de/nog_data/html/tree/ENOG41121GA epestfind swissprot:YECR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YECR_ECOLI garnier swissprot:YECR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YECR_ECOLI helixturnhelix swissprot:YECR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YECR_ECOLI hmoment swissprot:YECR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YECR_ECOLI iep swissprot:YECR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YECR_ECOLI inforesidue swissprot:YECR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YECR_ECOLI octanol swissprot:YECR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YECR_ECOLI pepcoil swissprot:YECR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YECR_ECOLI pepdigest swissprot:YECR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YECR_ECOLI pepinfo swissprot:YECR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YECR_ECOLI pepnet swissprot:YECR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YECR_ECOLI pepstats swissprot:YECR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YECR_ECOLI pepwheel swissprot:YECR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YECR_ECOLI pepwindow swissprot:YECR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YECR_ECOLI sigcleave swissprot:YECR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YECR_ECOLI ## Database ID URL or Descriptions # BioGrid 4262282 13 # EcoGene EG12707 ygbE # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR022721 DUF3561 # Organism YGBE_ECOLI Escherichia coli (strain K12) # PATRIC 32120904 VBIEscCol129921_2844 # PIR A65056 A65056 # Pfam PF12084 DUF3561 # ProDom PD070788 PD070788 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGBE_ECOLI Inner membrane protein YgbE # RefSeq NP_417229 NC_000913.3 # RefSeq WP_001246104 NZ_LN832404.1 # SUBCELLULAR LOCATION YGBE_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG ENOG4105N0Z Bacteria # eggNOG ENOG4111VSF LUCA BLAST swissprot:YGBE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGBE_ECOLI BioCyc ECOL316407:JW2719-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2719-MONOMER BioCyc EcoCyc:EG12707-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12707-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M74586 http://www.ebi.ac.uk/ena/data/view/M74586 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EchoBASE EB2569 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2569 EcoGene EG12707 http://www.ecogene.org/geneInfo.php?eg_id=EG12707 EnsemblBacteria AAC75791 http://www.ensemblgenomes.org/id/AAC75791 EnsemblBacteria AAC75791 http://www.ensemblgenomes.org/id/AAC75791 EnsemblBacteria BAE76826 http://www.ensemblgenomes.org/id/BAE76826 EnsemblBacteria BAE76826 http://www.ensemblgenomes.org/id/BAE76826 EnsemblBacteria BAE76826 http://www.ensemblgenomes.org/id/BAE76826 EnsemblBacteria b2749 http://www.ensemblgenomes.org/id/b2749 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 947268 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947268 HOGENOM HOG000124080 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000124080&db=HOGENOM6 InterPro IPR022721 http://www.ebi.ac.uk/interpro/entry/IPR022721 KEGG_Gene ecj:JW2719 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2719 KEGG_Gene eco:b2749 http://www.genome.jp/dbget-bin/www_bget?eco:b2749 OMA AVEEPTW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AVEEPTW PSORT swissprot:YGBE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGBE_ECOLI PSORT-B swissprot:YGBE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGBE_ECOLI PSORT2 swissprot:YGBE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGBE_ECOLI Pfam PF12084 http://pfam.xfam.org/family/PF12084 Phobius swissprot:YGBE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGBE_ECOLI ProteinModelPortal P46141 http://www.proteinmodelportal.org/query/uniprot/P46141 PubMed 1316900 http://www.ncbi.nlm.nih.gov/pubmed/1316900 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417229 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417229 RefSeq WP_001246104 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001246104 STRING 511145.b2749 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2749&targetmode=cogs UniProtKB YGBE_ECOLI http://www.uniprot.org/uniprot/YGBE_ECOLI UniProtKB-AC P46141 http://www.uniprot.org/uniprot/P46141 charge swissprot:YGBE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGBE_ECOLI eggNOG ENOG4105N0Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105N0Z eggNOG ENOG4111VSF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111VSF epestfind swissprot:YGBE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGBE_ECOLI garnier swissprot:YGBE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGBE_ECOLI helixturnhelix swissprot:YGBE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGBE_ECOLI hmoment swissprot:YGBE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGBE_ECOLI iep swissprot:YGBE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGBE_ECOLI inforesidue swissprot:YGBE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGBE_ECOLI octanol swissprot:YGBE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGBE_ECOLI pepcoil swissprot:YGBE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGBE_ECOLI pepdigest swissprot:YGBE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGBE_ECOLI pepinfo swissprot:YGBE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGBE_ECOLI pepnet swissprot:YGBE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGBE_ECOLI pepstats swissprot:YGBE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGBE_ECOLI pepwheel swissprot:YGBE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGBE_ECOLI pepwindow swissprot:YGBE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGBE_ECOLI sigcleave swissprot:YGBE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGBE_ECOLI ## Database ID URL or Descriptions # BioGrid 4261734 9 # EcoGene EG14018 kdgR # FUNCTION KDGR_ECOLI Transcriptional regulator of the kdgK gene for the kdg kinase and the kdgT gene for the kdg permease. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IBA:GO_Central. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # Gene3D 3.30.450.40 -; 1. # INTERACTION KDGR_ECOLI P64503 yebV; NbExp=3; IntAct=EBI-1123676, EBI-9126792; # IntAct P76268 4 # InterPro IPR005471 Tscrpt_reg_IclR_N # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR014757 Tscrpt_reg_IclR_C # InterPro IPR029016 GAF_dom-like # Organism KDGR_ECOLI Escherichia coli (strain K12) # PATRIC 32118975 VBIEscCol129921_1905 # PDB 1YSP X-ray; 1.80 A; A=88-263 # PIR C64944 C64944 # PROSITE PS51077 HTH_ICLR # PROSITE PS51078 ICLR_ED # Pfam PF01614 IclR # Pfam PF09339 HTH_IclR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName KDGR_ECOLI Transcriptional regulator KdgR # RefSeq NP_416341 NC_000913.3 # RefSeq WP_001262203 NZ_LN832404.1 # SIMILARITY Contains 1 HTH iclR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00393}. # SIMILARITY Contains 1 iclR-ED (iclR effector binding) domain. {ECO:0000255|PROSITE-ProRule PRU00394}. # SMART SM00346 HTH_ICLR # SUPFAM SSF46785 SSF46785 # SUPFAM SSF55781 SSF55781 # eggNOG COG1414 LUCA # eggNOG ENOG4105J4Q Bacteria BLAST swissprot:KDGR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:KDGR_ECOLI BioCyc ECOL316407:JW1816-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1816-MONOMER BioCyc EcoCyc:G7003-MONOMER http://biocyc.org/getid?id=EcoCyc:G7003-MONOMER DIP DIP-10057N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10057N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3772 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3772 EcoGene EG14018 http://www.ecogene.org/geneInfo.php?eg_id=EG14018 EnsemblBacteria AAC74897 http://www.ensemblgenomes.org/id/AAC74897 EnsemblBacteria AAC74897 http://www.ensemblgenomes.org/id/AAC74897 EnsemblBacteria BAA15635 http://www.ensemblgenomes.org/id/BAA15635 EnsemblBacteria BAA15635 http://www.ensemblgenomes.org/id/BAA15635 EnsemblBacteria BAA15635 http://www.ensemblgenomes.org/id/BAA15635 EnsemblBacteria b1827 http://www.ensemblgenomes.org/id/b1827 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 3.30.450.40 http://www.cathdb.info/version/latest/superfamily/3.30.450.40 GeneID 946129 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946129 HOGENOM HOG000107041 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000107041&db=HOGENOM6 InParanoid P76268 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76268 IntAct P76268 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76268* InterPro IPR005471 http://www.ebi.ac.uk/interpro/entry/IPR005471 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR014757 http://www.ebi.ac.uk/interpro/entry/IPR014757 InterPro IPR029016 http://www.ebi.ac.uk/interpro/entry/IPR029016 KEGG_Gene ecj:JW1816 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1816 KEGG_Gene eco:b1827 http://www.genome.jp/dbget-bin/www_bget?eco:b1827 OMA WRDREEV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WRDREEV PDB 1YSP http://www.ebi.ac.uk/pdbe-srv/view/entry/1YSP PDBsum 1YSP http://www.ebi.ac.uk/pdbsum/1YSP PROSITE PS51077 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51077 PROSITE PS51078 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51078 PSORT swissprot:KDGR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:KDGR_ECOLI PSORT-B swissprot:KDGR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:KDGR_ECOLI PSORT2 swissprot:KDGR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:KDGR_ECOLI Pfam PF01614 http://pfam.xfam.org/family/PF01614 Pfam PF09339 http://pfam.xfam.org/family/PF09339 Phobius swissprot:KDGR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:KDGR_ECOLI PhylomeDB P76268 http://phylomedb.org/?seqid=P76268 ProteinModelPortal P76268 http://www.proteinmodelportal.org/query/uniprot/P76268 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416341 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416341 RefSeq WP_001262203 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001262203 SMART SM00346 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00346 SMR P76268 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76268 STRING 511145.b1827 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1827&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SUPFAM SSF55781 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55781 UniProtKB KDGR_ECOLI http://www.uniprot.org/uniprot/KDGR_ECOLI UniProtKB-AC P76268 http://www.uniprot.org/uniprot/P76268 charge swissprot:KDGR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:KDGR_ECOLI eggNOG COG1414 http://eggnogapi.embl.de/nog_data/html/tree/COG1414 eggNOG ENOG4105J4Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105J4Q epestfind swissprot:KDGR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:KDGR_ECOLI garnier swissprot:KDGR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:KDGR_ECOLI helixturnhelix swissprot:KDGR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:KDGR_ECOLI hmoment swissprot:KDGR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:KDGR_ECOLI iep swissprot:KDGR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:KDGR_ECOLI inforesidue swissprot:KDGR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:KDGR_ECOLI octanol swissprot:KDGR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:KDGR_ECOLI pepcoil swissprot:KDGR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:KDGR_ECOLI pepdigest swissprot:KDGR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:KDGR_ECOLI pepinfo swissprot:KDGR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:KDGR_ECOLI pepnet swissprot:KDGR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:KDGR_ECOLI pepstats swissprot:KDGR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:KDGR_ECOLI pepwheel swissprot:KDGR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:KDGR_ECOLI pepwindow swissprot:KDGR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:KDGR_ECOLI sigcleave swissprot:KDGR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:KDGR_ECOLI ## Database ID URL or Descriptions # BioGrid 4261051 8 # CATALYTIC ACTIVITY MPGP_ECOLI 2-O-(alpha-D-mannosyl)-3-phosphoglycerate + H(2)O = 2-O-(alpha-D-mannosyl)-D-glycerate + phosphate. {ECO 0000255|HAMAP-Rule MF_00617, ECO 0000269|PubMed 25848029}. # COFACTOR MPGP_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_00617, ECO 0000269|PubMed 25848029}; # EcoGene EG14039 yedP # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0016791 phosphatase activity; IBA:GO_Central. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0050531 mannosyl-3-phosphoglycerate phosphatase activity; IEA:UniProtKB-HAMAP. # GO_process GO:0044283 small molecule biosynthetic process; IBA:GO_Central. # GO_process GO:0051479 mannosylglycerate biosynthetic process; IEA:InterPro. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.1000 -; 2. # HAMAP MF_00617 MPGP_rel # IntAct P76329 3 # InterPro IPR006379 HAD-SF_hydro_IIB # InterPro IPR006381 HAD-SF-IIB-MPGP # InterPro IPR012815 MPG_Pase # InterPro IPR023214 HAD-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00051 Fructose and mannose metabolism # Organism MPGP_ECOLI Escherichia coli (strain K12) # PATRIC 32119237 VBIEscCol129921_2033 # PDB 1XVI X-ray; 2.26 A; A/B=1-271 # PIR G64959 G64959 # Pfam PF08282 Hydrolase_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MPGP_ECOLI Mannosyl-3-phosphoglycerate phosphatase {ECO 0000255|HAMAP-Rule MF_00617, ECO 0000303|PubMed 25848029} # RefSeq NP_416464 NC_000913.3 # RefSeq WP_000491520 NZ_LN832404.1 # SIMILARITY Belongs to the HAD-like hydrolase superfamily. MPGP family. {ECO:0000255|HAMAP-Rule MF_00617}. # SUBCELLULAR LOCATION MPGP_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00617}. # SUPFAM SSF56784 SSF56784 # TIGRFAMs TIGR01484 HAD-SF-IIB # TIGRFAMs TIGR01486 HAD-SF-IIB-MPGP # eggNOG COG3769 LUCA # eggNOG ENOG4108ZFX Bacteria BLAST swissprot:MPGP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MPGP_ECOLI BioCyc ECOL316407:JW1938-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1938-MONOMER BioCyc EcoCyc:G7048-MONOMER http://biocyc.org/getid?id=EcoCyc:G7048-MONOMER COG COG3769 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3769 DIP DIP-11848N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11848N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.1423570112 http://dx.doi.org/10.1073/pnas.1423570112 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.3.70 {ECO:0000255|HAMAP-Rule:MF_00617, ECO:0000269|PubMed:25848029} http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.70 {ECO:0000255|HAMAP-Rule:MF_00617, ECO:0000269|PubMed:25848029} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.3.70 {ECO:0000255|HAMAP-Rule:MF_00617, ECO:0000269|PubMed:25848029} http://enzyme.expasy.org/EC/3.1.3.70 {ECO:0000255|HAMAP-Rule:MF_00617, ECO:0000269|PubMed:25848029} EchoBASE EB3793 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3793 EcoGene EG14039 http://www.ecogene.org/geneInfo.php?eg_id=EG14039 EnsemblBacteria AAC75021 http://www.ensemblgenomes.org/id/AAC75021 EnsemblBacteria AAC75021 http://www.ensemblgenomes.org/id/AAC75021 EnsemblBacteria BAE76555 http://www.ensemblgenomes.org/id/BAE76555 EnsemblBacteria BAE76555 http://www.ensemblgenomes.org/id/BAE76555 EnsemblBacteria BAE76555 http://www.ensemblgenomes.org/id/BAE76555 EnsemblBacteria b1955 http://www.ensemblgenomes.org/id/b1955 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0050531 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050531 GO_process GO:0044283 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044283 GO_process GO:0051479 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051479 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.1000 http://www.cathdb.info/version/latest/superfamily/3.40.50.1000 GeneID 946472 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946472 HAMAP MF_00617 http://hamap.expasy.org/unirule/MF_00617 HOGENOM HOG000224319 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000224319&db=HOGENOM6 IntAct P76329 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76329* IntEnz 3.1.3.70 {ECO:0000255|HAMAP-Rule:MF_00617, ECO:0000269|PubMed:25848029} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.70 {ECO:0000255|HAMAP-Rule:MF_00617, ECO:0000269|PubMed:25848029} InterPro IPR006379 http://www.ebi.ac.uk/interpro/entry/IPR006379 InterPro IPR006381 http://www.ebi.ac.uk/interpro/entry/IPR006381 InterPro IPR012815 http://www.ebi.ac.uk/interpro/entry/IPR012815 InterPro IPR023214 http://www.ebi.ac.uk/interpro/entry/IPR023214 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1938 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1938 KEGG_Gene eco:b1955 http://www.genome.jp/dbget-bin/www_bget?eco:b1955 KEGG_Orthology KO:K07026 http://www.genome.jp/dbget-bin/www_bget?KO:K07026 KEGG_Pathway ko00051 http://www.genome.jp/kegg-bin/show_pathway?ko00051 KEGG_Reaction rn:R05790 http://www.genome.jp/dbget-bin/www_bget?rn:R05790 OMA DHHTYSF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DHHTYSF PDB 1XVI http://www.ebi.ac.uk/pdbe-srv/view/entry/1XVI PDBsum 1XVI http://www.ebi.ac.uk/pdbsum/1XVI PSORT swissprot:MPGP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MPGP_ECOLI PSORT-B swissprot:MPGP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MPGP_ECOLI PSORT2 swissprot:MPGP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MPGP_ECOLI Pfam PF08282 http://pfam.xfam.org/family/PF08282 Phobius swissprot:MPGP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MPGP_ECOLI ProteinModelPortal P76329 http://www.proteinmodelportal.org/query/uniprot/P76329 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 25848029 http://www.ncbi.nlm.nih.gov/pubmed/25848029 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416464 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416464 RefSeq WP_000491520 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000491520 SMR P76329 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76329 STRING 511145.b1955 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1955&targetmode=cogs STRING COG3769 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3769&targetmode=cogs SUPFAM SSF56784 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784 TIGRFAMs TIGR01484 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01484 TIGRFAMs TIGR01486 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01486 UniProtKB MPGP_ECOLI http://www.uniprot.org/uniprot/MPGP_ECOLI UniProtKB-AC P76329 http://www.uniprot.org/uniprot/P76329 charge swissprot:MPGP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MPGP_ECOLI eggNOG COG3769 http://eggnogapi.embl.de/nog_data/html/tree/COG3769 eggNOG ENOG4108ZFX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZFX epestfind swissprot:MPGP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MPGP_ECOLI garnier swissprot:MPGP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MPGP_ECOLI helixturnhelix swissprot:MPGP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MPGP_ECOLI hmoment swissprot:MPGP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MPGP_ECOLI iep swissprot:MPGP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MPGP_ECOLI inforesidue swissprot:MPGP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MPGP_ECOLI octanol swissprot:MPGP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MPGP_ECOLI pepcoil swissprot:MPGP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MPGP_ECOLI pepdigest swissprot:MPGP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MPGP_ECOLI pepinfo swissprot:MPGP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MPGP_ECOLI pepnet swissprot:MPGP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MPGP_ECOLI pepstats swissprot:MPGP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MPGP_ECOLI pepwheel swissprot:MPGP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MPGP_ECOLI pepwindow swissprot:MPGP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MPGP_ECOLI sigcleave swissprot:MPGP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MPGP_ECOLI ## Database ID URL or Descriptions # AltName EIIA-Chb {ECO:0000303|PubMed 2092358} # AltName EIII-Chb {ECO:0000303|PubMed 2179047} # AltName IIIcel {ECO:0000303|PubMed 2179047} # AltName N,N'-diacetylchitobiose-specific phosphotransferase enzyme IIA component {ECO:0000303|PubMed 2092358} # BioGrid 4259134 10 # CATALYTIC ACTIVITY PTQA_ECOLI [Protein]-N(pi)-phospho-L-histidine + N,N'- diacetylchitobiose(Side 1) = [protein]-L-histidine + N,N'- diacetylchitobiose 6'-phosphate(Side 2). {ECO 0000269|PubMed 10913117, ECO 0000269|PubMed 10913118}. # CAUTION Was originally (PubMed:2179047) characterized as part of a cryptic cel operon for a cellobiose degradation system. The Cel+ phenotype is due to mutations making expression chitobiose- independent and altering the substrate specificity. {ECO 0000305|PubMed:2179047}. # CDD cd00215 PTS_IIA_lac # COFACTOR PTQA_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 10913118, ECO 0000305|PubMed 15654077}; Note=Can also use copper and nickel with lower efficiency. {ECO 0000269|PubMed 10913118}; # DOMAIN PTQA_ECOLI The PTS EIIA type-3 domain is phosphorylated by phospho- HPr on a histidyl residue. Then, it transfers the phosphoryl group to the PTS EIIB type-3 domain. {ECO 0000255|PROSITE- ProRule PRU00418}. # EcoGene EG10142 chbA # FUNCTION PTQA_ECOLI The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ChbABC PTS system is involved in the transport of the chitin disaccharide N,N'-diacetylchitobiose (GlcNAc2) (PubMed 10913118, PubMed 10913117). Also able to use N,N',N''-triacetyl chitotriose (GlcNAc3) (PubMed 10913117). {ECO 0000269|PubMed 10913117, ECO 0000269|PubMed 10913118, ECO 0000305|PubMed 2092358}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0090566 protein-phosphocysteine-N,N'-diacetylchitobiose phosphotransferase system transporter activity; IDA:EcoCyc. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IDA:EcoCyc. # GO_process GO:0051260 protein homooligomerization; IDA:EcoCyc. # GO_process GO:1902815 N,N'-diacetylchitobiose import; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0006810 transport # Gene3D 1.20.58.80 -; 1. # INDUCTION By GlcNAc2, GlcNAc3 and beta-N,N'-diacetylchitobiose (Me-TCB). {ECO:0000269|PubMed 10913117}. # IntAct P69791 11 # InterPro IPR003188 PTS_IIA_lac/cel # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00275 PTS system, cellobiose-specific II component # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02060 Phosphotransferase system (PTS) # Organism PTQA_ECOLI Escherichia coli (strain K12) # PATRIC 32118781 VBIEscCol129921_1808 # PDB 1WCR NMR; -; A/B/C=14-116 # PDB 2LRK NMR; -; A/B/C=14-116 # PDB 2LRL NMR; -; A/B/C=14-116 # PDB 2WWV NMR; -; A/B/C=14-116 # PDB 2WY2 NMR; -; A/B/C=14-116 # PIR H64932 H64932 # PIRSF PIRSF000699 PTS_IILac_III # PROSITE PS51095 PTS_EIIA_TYPE_3 # Pfam PF02255 PTS_IIA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PTS system N,N'-diacetylchitobiose-specific EIIA component {ECO:0000303|PubMed 2092358} # RefSeq NP_416250 NC_000913.3 # RefSeq WP_000968919 NZ_LN832404.1 # SIMILARITY Contains 1 PTS EIIA type-3 domain. {ECO:0000255|PROSITE-ProRule PRU00418}. # SUBCELLULAR LOCATION PTQA_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT PTQA_ECOLI Forms a complex with ChbB (EIIB) (PubMed 10913119, PubMed 10913122, PubMed 19959833). ChbA is a homotrimer (PubMed 10913122, PubMed 15654077, PubMed 19959833, PubMed 22593574). The interface of the homotrimer is stabilized by metal cations such as magnesium, copper or nickel (PubMed 15654077). {ECO 0000269|PubMed 10913119, ECO 0000269|PubMed 10913122, ECO 0000269|PubMed 15654077, ECO 0000269|PubMed 19959833, ECO 0000269|PubMed 22593574, ECO 0000305|PubMed 10913118}. # SUPFAM SSF46973 SSF46973 # TCDB 4.A.3.2 the pts lactose-n,n'-diacetylchitobiose-Beta-glucoside (lac) family # TIGRFAMs TIGR00823 EIIA-LAC # eggNOG COG1447 LUCA # eggNOG ENOG4105VCP Bacteria BLAST swissprot:PTQA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTQA_ECOLI BioCyc ECOL316407:JW1725-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1725-MONOMER BioCyc EcoCyc:CELC-MONOMER http://biocyc.org/getid?id=EcoCyc:CELC-MONOMER BioCyc MetaCyc:CELC-MONOMER http://biocyc.org/getid?id=MetaCyc:CELC-MONOMER COG COG1447 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1447 DIP DIP-9265N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9265N DOI 10.1016/0923-2508(90)90079-6 http://dx.doi.org/10.1016/0923-2508(90)90079-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.94.26.14367 http://dx.doi.org/10.1073/pnas.94.26.14367 DOI 10.1074/jbc.M001043200 http://dx.doi.org/10.1074/jbc.M001043200 DOI 10.1074/jbc.M001044200 http://dx.doi.org/10.1074/jbc.M001044200 DOI 10.1074/jbc.M001045200 http://dx.doi.org/10.1074/jbc.M001045200 DOI 10.1074/jbc.M001717200 http://dx.doi.org/10.1074/jbc.M001717200 DOI 10.1074/jbc.M109.080937 http://dx.doi.org/10.1074/jbc.M109.080937 DOI 10.1074/jbc.M112.371492 http://dx.doi.org/10.1074/jbc.M112.371492 DOI 10.1074/jbc.M414300200 http://dx.doi.org/10.1074/jbc.M414300200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.196 {ECO:0000269|PubMed:10913117, ECO:0000269|PubMed:10913118} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.196 {ECO:0000269|PubMed:10913117, ECO:0000269|PubMed:10913118} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M93570 http://www.ebi.ac.uk/ena/data/view/M93570 EMBL M93571 http://www.ebi.ac.uk/ena/data/view/M93571 EMBL M93572 http://www.ebi.ac.uk/ena/data/view/M93572 EMBL M93573 http://www.ebi.ac.uk/ena/data/view/M93573 EMBL M93574 http://www.ebi.ac.uk/ena/data/view/M93574 EMBL M93575 http://www.ebi.ac.uk/ena/data/view/M93575 EMBL M93576 http://www.ebi.ac.uk/ena/data/view/M93576 EMBL M93577 http://www.ebi.ac.uk/ena/data/view/M93577 EMBL M93591 http://www.ebi.ac.uk/ena/data/view/M93591 EMBL M93592 http://www.ebi.ac.uk/ena/data/view/M93592 EMBL M93593 http://www.ebi.ac.uk/ena/data/view/M93593 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X52890 http://www.ebi.ac.uk/ena/data/view/X52890 ENZYME 2.7.1.196 {ECO:0000269|PubMed:10913117, ECO:0000269|PubMed:10913118} http://enzyme.expasy.org/EC/2.7.1.196 {ECO:0000269|PubMed:10913117, ECO:0000269|PubMed:10913118} EchoBASE EB0140 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0140 EcoGene EG10142 http://www.ecogene.org/geneInfo.php?eg_id=EG10142 EnsemblBacteria AAC74806 http://www.ensemblgenomes.org/id/AAC74806 EnsemblBacteria AAC74806 http://www.ensemblgenomes.org/id/AAC74806 EnsemblBacteria BAA15517 http://www.ensemblgenomes.org/id/BAA15517 EnsemblBacteria BAA15517 http://www.ensemblgenomes.org/id/BAA15517 EnsemblBacteria BAA15517 http://www.ensemblgenomes.org/id/BAA15517 EnsemblBacteria b1736 http://www.ensemblgenomes.org/id/b1736 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0090566 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090566 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GO_process GO:0051260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260 GO_process GO:1902815 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902815 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 1.20.58.80 http://www.cathdb.info/version/latest/superfamily/1.20.58.80 GeneID 946244 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946244 HOGENOM HOG000224338 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000224338&db=HOGENOM6 InParanoid P69791 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P69791 IntAct P69791 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69791* IntEnz 2.7.1.196 {ECO:0000269|PubMed:10913117, ECO:0000269|PubMed:10913118} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.196 {ECO:0000269|PubMed:10913117, ECO:0000269|PubMed:10913118} InterPro IPR003188 http://www.ebi.ac.uk/interpro/entry/IPR003188 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1725 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1725 KEGG_Gene eco:b1736 http://www.genome.jp/dbget-bin/www_bget?eco:b1736 KEGG_Orthology KO:K02759 http://www.genome.jp/dbget-bin/www_bget?KO:K02759 KEGG_Pathway ko02060 http://www.genome.jp/kegg-bin/show_pathway?ko02060 OMA MEQSRMA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MEQSRMA PDB 1WCR http://www.ebi.ac.uk/pdbe-srv/view/entry/1WCR PDB 2LRK http://www.ebi.ac.uk/pdbe-srv/view/entry/2LRK PDB 2LRL http://www.ebi.ac.uk/pdbe-srv/view/entry/2LRL PDB 2WWV http://www.ebi.ac.uk/pdbe-srv/view/entry/2WWV PDB 2WY2 http://www.ebi.ac.uk/pdbe-srv/view/entry/2WY2 PDBsum 1WCR http://www.ebi.ac.uk/pdbsum/1WCR PDBsum 2LRK http://www.ebi.ac.uk/pdbsum/2LRK PDBsum 2LRL http://www.ebi.ac.uk/pdbsum/2LRL PDBsum 2WWV http://www.ebi.ac.uk/pdbsum/2WWV PDBsum 2WY2 http://www.ebi.ac.uk/pdbsum/2WY2 PROSITE PS51095 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51095 PSORT swissprot:PTQA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTQA_ECOLI PSORT-B swissprot:PTQA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTQA_ECOLI PSORT2 swissprot:PTQA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTQA_ECOLI Pfam PF02255 http://pfam.xfam.org/family/PF02255 Phobius swissprot:PTQA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTQA_ECOLI PhylomeDB P69791 http://phylomedb.org/?seqid=P69791 ProteinModelPortal P69791 http://www.proteinmodelportal.org/query/uniprot/P69791 PubMed 10913117 http://www.ncbi.nlm.nih.gov/pubmed/10913117 PubMed 10913118 http://www.ncbi.nlm.nih.gov/pubmed/10913118 PubMed 10913119 http://www.ncbi.nlm.nih.gov/pubmed/10913119 PubMed 10913122 http://www.ncbi.nlm.nih.gov/pubmed/10913122 PubMed 15654077 http://www.ncbi.nlm.nih.gov/pubmed/15654077 PubMed 1630305 http://www.ncbi.nlm.nih.gov/pubmed/1630305 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19959833 http://www.ncbi.nlm.nih.gov/pubmed/19959833 PubMed 2092358 http://www.ncbi.nlm.nih.gov/pubmed/2092358 PubMed 2179047 http://www.ncbi.nlm.nih.gov/pubmed/2179047 PubMed 22593574 http://www.ncbi.nlm.nih.gov/pubmed/22593574 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9405618 http://www.ncbi.nlm.nih.gov/pubmed/9405618 RefSeq NP_416250 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416250 RefSeq WP_000968919 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000968919 SMR P69791 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69791 STRING 511145.b1736 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1736&targetmode=cogs STRING COG1447 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1447&targetmode=cogs SUPFAM SSF46973 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46973 TCDB 4.A.3.2 http://www.tcdb.org/search/result.php?tc=4.A.3.2 TIGRFAMs TIGR00823 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00823 UniProtKB PTQA_ECOLI http://www.uniprot.org/uniprot/PTQA_ECOLI UniProtKB-AC P69791 http://www.uniprot.org/uniprot/P69791 charge swissprot:PTQA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTQA_ECOLI eggNOG COG1447 http://eggnogapi.embl.de/nog_data/html/tree/COG1447 eggNOG ENOG4105VCP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VCP epestfind swissprot:PTQA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTQA_ECOLI garnier swissprot:PTQA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTQA_ECOLI helixturnhelix swissprot:PTQA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTQA_ECOLI hmoment swissprot:PTQA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTQA_ECOLI iep swissprot:PTQA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTQA_ECOLI inforesidue swissprot:PTQA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTQA_ECOLI octanol swissprot:PTQA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTQA_ECOLI pepcoil swissprot:PTQA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTQA_ECOLI pepdigest swissprot:PTQA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTQA_ECOLI pepinfo swissprot:PTQA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTQA_ECOLI pepnet swissprot:PTQA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTQA_ECOLI pepstats swissprot:PTQA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTQA_ECOLI pepwheel swissprot:PTQA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTQA_ECOLI pepwindow swissprot:PTQA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTQA_ECOLI sigcleave swissprot:PTQA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTQA_ECOLI ## Database ID URL or Descriptions # AltName MOAE_ECOLI MPT synthase subunit 2 # AltName MOAE_ECOLI Molybdenum cofactor biosynthesis protein E # AltName MOAE_ECOLI Molybdopterin-converting factor large subunit # AltName MOAE_ECOLI Molybdopterin-converting factor subunit 2 # BRENDA 2.8.1.12 2026 # BioGrid 4262180 10 # CATALYTIC ACTIVITY Cyclic pyranopterin phosphate + 2 [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH(2)- C(O)SH + H(2)O = molybdopterin + 2 [molybdopterin-synthase sulfur- carrier protein]. {ECO:0000269|PubMed 12571226}. # CDD cd00756 MoaE # EcoGene EG11598 moaE # FUNCTION MOAE_ECOLI Converts molybdopterin precursor Z to molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by MoaD. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0030366 molybdopterin synthase activity; IBA:GO_Central. # GO_process GO:0006777 Mo-molybdopterin cofactor biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0032324 molybdopterin cofactor biosynthetic process; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.90.1170.40 -; 1. # INDUCTION MOAE_ECOLI By anaerobiosis, repressed by the molybdenum cofactor. # INTERACTION MOAE_ECOLI P30748 moaD; NbExp=7; IntAct=EBI-554376, EBI-554366; # IntAct P30749 21 # InterPro IPR003448 Mopterin_biosynth_MoaE # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00790 Folate biosynthesis # KEGG_Pathway ko04122 Sulfur relay system # MASS SPECTROMETRY Mass=16849.7; Mass_error=0.7; Method=Electrospray; Range=2-150; Evidence={ECO:0000269|PubMed 8514782}; # MASS SPECTROMETRY Mass=16851; Method=API; Range=2-150; Evidence={ECO:0000269|PubMed 11135669}; # MISCELLANEOUS MOAE_ECOLI The cross-link is not seen in all structures of the MoaE-MoaD complex. # Organism MOAE_ECOLI Escherichia coli (strain K12) # PANTHER PTHR23404:SF2 PTHR23404:SF2 # PATHWAY MOAE_ECOLI Cofactor biosynthesis; molybdopterin biosynthesis. # PATRIC 32116771 VBIEscCol129921_0811 # PDB 1FM0 X-ray; 1.45 A; E=1-150 # PDB 1FMA X-ray; 1.58 A; E=1-150 # PDB 1NVI X-ray; 1.90 A; E=1-150 # PDB 1NVJ X-ray; 2.15 A; A/B/C/D/E/F=1-140 # PDB 3BII X-ray; 2.50 A; E=2-150 # PIR S35002 S31883 # Pfam PF02391 MoaE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MOAE_ECOLI Molybdopterin synthase catalytic subunit # RefSeq NP_415306 NC_000913.3 # RefSeq WP_000852296 NZ_LN832404.1 # SIMILARITY Belongs to the MoaE family. {ECO 0000305}. # SUBUNIT MOAE_ECOLI Heterotetramer of 2 MoaD subunits and 2 MoaE subunits. Also stable as homodimer. The enzyme changes between these two forms during catalysis. {ECO 0000269|PubMed 11135669, ECO 0000269|PubMed 12571227}. # SUPFAM SSF54690 SSF54690 # eggNOG COG0314 LUCA # eggNOG ENOG4108ZAF Bacteria BLAST swissprot:MOAE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MOAE_ECOLI BioCyc ECOL316407:JW0768-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0768-MONOMER BioCyc EcoCyc:EG11598-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11598-MONOMER BioCyc MetaCyc:EG11598-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11598-MONOMER COG COG0314 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0314 DIP DIP-10232N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10232N DOI 10.1038/83034 http://dx.doi.org/10.1038/83034 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M300449200 http://dx.doi.org/10.1074/jbc.M300449200 DOI 10.1074/jbc.M300453200 http://dx.doi.org/10.1074/jbc.M300453200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1993.tb01652.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb01652.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.8.1.12 http://www.genome.jp/dbget-bin/www_bget?EC:2.8.1.12 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X70420 http://www.ebi.ac.uk/ena/data/view/X70420 ENZYME 2.8.1.12 http://enzyme.expasy.org/EC/2.8.1.12 EchoBASE EB1555 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1555 EcoGene EG11598 http://www.ecogene.org/geneInfo.php?eg_id=EG11598 EnsemblBacteria AAC73872 http://www.ensemblgenomes.org/id/AAC73872 EnsemblBacteria AAC73872 http://www.ensemblgenomes.org/id/AAC73872 EnsemblBacteria BAA35443 http://www.ensemblgenomes.org/id/BAA35443 EnsemblBacteria BAA35443 http://www.ensemblgenomes.org/id/BAA35443 EnsemblBacteria BAA35443 http://www.ensemblgenomes.org/id/BAA35443 EnsemblBacteria b0785 http://www.ensemblgenomes.org/id/b0785 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0030366 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030366 GO_process GO:0006777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006777 GO_process GO:0032324 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032324 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.90.1170.40 http://www.cathdb.info/version/latest/superfamily/3.90.1170.40 GeneID 945399 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945399 HOGENOM HOG000280876 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000280876&db=HOGENOM6 InParanoid P30749 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30749 IntAct P30749 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P30749* IntEnz 2.8.1.12 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.8.1.12 InterPro IPR003448 http://www.ebi.ac.uk/interpro/entry/IPR003448 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0768 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0768 KEGG_Gene eco:b0785 http://www.genome.jp/dbget-bin/www_bget?eco:b0785 KEGG_Orthology KO:K03635 http://www.genome.jp/dbget-bin/www_bget?KO:K03635 KEGG_Pathway ko00790 http://www.genome.jp/kegg-bin/show_pathway?ko00790 KEGG_Pathway ko04122 http://www.genome.jp/kegg-bin/show_pathway?ko04122 KEGG_Reaction rn:R09395 http://www.genome.jp/dbget-bin/www_bget?rn:R09395 MINT MINT-155543 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-155543 OMA RERWPLN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RERWPLN PANTHER PTHR23404:SF2 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23404:SF2 PDB 1FM0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1FM0 PDB 1FMA http://www.ebi.ac.uk/pdbe-srv/view/entry/1FMA PDB 1NVI http://www.ebi.ac.uk/pdbe-srv/view/entry/1NVI PDB 1NVJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1NVJ PDB 3BII http://www.ebi.ac.uk/pdbe-srv/view/entry/3BII PDBsum 1FM0 http://www.ebi.ac.uk/pdbsum/1FM0 PDBsum 1FMA http://www.ebi.ac.uk/pdbsum/1FMA PDBsum 1NVI http://www.ebi.ac.uk/pdbsum/1NVI PDBsum 1NVJ http://www.ebi.ac.uk/pdbsum/1NVJ PDBsum 3BII http://www.ebi.ac.uk/pdbsum/3BII PSORT swissprot:MOAE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MOAE_ECOLI PSORT-B swissprot:MOAE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MOAE_ECOLI PSORT2 swissprot:MOAE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MOAE_ECOLI Pfam PF02391 http://pfam.xfam.org/family/PF02391 Phobius swissprot:MOAE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MOAE_ECOLI PhylomeDB P30749 http://phylomedb.org/?seqid=P30749 ProteinModelPortal P30749 http://www.proteinmodelportal.org/query/uniprot/P30749 PubMed 11135669 http://www.ncbi.nlm.nih.gov/pubmed/11135669 PubMed 12571226 http://www.ncbi.nlm.nih.gov/pubmed/12571226 PubMed 12571227 http://www.ncbi.nlm.nih.gov/pubmed/12571227 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8361352 http://www.ncbi.nlm.nih.gov/pubmed/8361352 PubMed 8514782 http://www.ncbi.nlm.nih.gov/pubmed/8514782 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415306 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415306 RefSeq WP_000852296 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000852296 SMR P30749 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P30749 STRING 511145.b0785 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0785&targetmode=cogs STRING COG0314 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0314&targetmode=cogs SUPFAM SSF54690 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54690 UniProtKB MOAE_ECOLI http://www.uniprot.org/uniprot/MOAE_ECOLI UniProtKB-AC P30749 http://www.uniprot.org/uniprot/P30749 charge swissprot:MOAE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MOAE_ECOLI eggNOG COG0314 http://eggnogapi.embl.de/nog_data/html/tree/COG0314 eggNOG ENOG4108ZAF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZAF epestfind swissprot:MOAE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MOAE_ECOLI garnier swissprot:MOAE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MOAE_ECOLI helixturnhelix swissprot:MOAE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MOAE_ECOLI hmoment swissprot:MOAE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MOAE_ECOLI iep swissprot:MOAE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MOAE_ECOLI inforesidue swissprot:MOAE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MOAE_ECOLI octanol swissprot:MOAE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MOAE_ECOLI pepcoil swissprot:MOAE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MOAE_ECOLI pepdigest swissprot:MOAE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MOAE_ECOLI pepinfo swissprot:MOAE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MOAE_ECOLI pepnet swissprot:MOAE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MOAE_ECOLI pepstats swissprot:MOAE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MOAE_ECOLI pepwheel swissprot:MOAE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MOAE_ECOLI pepwindow swissprot:MOAE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MOAE_ECOLI sigcleave swissprot:MOAE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MOAE_ECOLI ## Database ID URL or Descriptions # BioGrid 4262788 13 # DISRUPTION PHENOTYPE No visible phenotype. {ECO:0000269|PubMed 2684780}. # EcoGene EG10951 smp # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # IntAct P0AGC7 6 # InterPro IPR019305 Uncharacterised_Smp # Organism SMP_ECOLI Escherichia coli (strain K12) # PATRIC 32124390 VBIEscCol129921_4535 # PIR A26227 A26227 # PTM SMP_ECOLI The signal sequence may not be cleaved. # Pfam PF10144 SMP_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SMP_ECOLI Protein Smp # RefSeq NP_418804 NC_000913.3 # RefSeq WP_000124615 NZ_LN832404.1 # SIMILARITY Belongs to the Smp family. {ECO 0000305}. # SUBCELLULAR LOCATION SMP_ECOLI Cell membrane {ECO 0000269|PubMed 2684780}; Single-pass membrane protein {ECO 0000269|PubMed 2684780}. # eggNOG COG3726 LUCA # eggNOG ENOG41062Z9 Bacteria BLAST swissprot:SMP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SMP_ECOLI BioCyc ECOL316407:JW4350-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4350-MONOMER BioCyc EcoCyc:EG10951-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10951-MONOMER COG COG3726 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3726 DIP DIP-35920N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35920N DOI 10.1016/0378-1119(89)90047-4 http://dx.doi.org/10.1016/0378-1119(89)90047-4 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L27665 http://www.ebi.ac.uk/ena/data/view/L27665 EMBL M30784 http://www.ebi.ac.uk/ena/data/view/M30784 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X03046 http://www.ebi.ac.uk/ena/data/view/X03046 EchoBASE EB0944 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0944 EcoGene EG10951 http://www.ecogene.org/geneInfo.php?eg_id=EG10951 EnsemblBacteria AAC77340 http://www.ensemblgenomes.org/id/AAC77340 EnsemblBacteria AAC77340 http://www.ensemblgenomes.org/id/AAC77340 EnsemblBacteria BAE78376 http://www.ensemblgenomes.org/id/BAE78376 EnsemblBacteria BAE78376 http://www.ensemblgenomes.org/id/BAE78376 EnsemblBacteria BAE78376 http://www.ensemblgenomes.org/id/BAE78376 EnsemblBacteria b4387 http://www.ensemblgenomes.org/id/b4387 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 946089 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946089 HOGENOM HOG000127853 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000127853&db=HOGENOM6 IntAct P0AGC7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AGC7* InterPro IPR019305 http://www.ebi.ac.uk/interpro/entry/IPR019305 KEGG_Gene ecj:JW4350 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4350 KEGG_Gene eco:b4387 http://www.genome.jp/dbget-bin/www_bget?eco:b4387 KEGG_Orthology KO:K07186 http://www.genome.jp/dbget-bin/www_bget?KO:K07186 OMA RQVDNTT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RQVDNTT PSORT swissprot:SMP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SMP_ECOLI PSORT-B swissprot:SMP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SMP_ECOLI PSORT2 swissprot:SMP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SMP_ECOLI Pfam PF10144 http://pfam.xfam.org/family/PF10144 Phobius swissprot:SMP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SMP_ECOLI ProteinModelPortal P0AGC7 http://www.proteinmodelportal.org/query/uniprot/P0AGC7 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2684780 http://www.ncbi.nlm.nih.gov/pubmed/2684780 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8206909 http://www.ncbi.nlm.nih.gov/pubmed/8206909 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418804 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418804 RefSeq WP_000124615 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000124615 SMR P0AGC7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AGC7 STRING 511145.b4387 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4387&targetmode=cogs STRING COG3726 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3726&targetmode=cogs UniProtKB SMP_ECOLI http://www.uniprot.org/uniprot/SMP_ECOLI UniProtKB-AC P0AGC7 http://www.uniprot.org/uniprot/P0AGC7 charge swissprot:SMP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SMP_ECOLI eggNOG COG3726 http://eggnogapi.embl.de/nog_data/html/tree/COG3726 eggNOG ENOG41062Z9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41062Z9 epestfind swissprot:SMP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SMP_ECOLI garnier swissprot:SMP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SMP_ECOLI helixturnhelix swissprot:SMP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SMP_ECOLI hmoment swissprot:SMP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SMP_ECOLI iep swissprot:SMP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SMP_ECOLI inforesidue swissprot:SMP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SMP_ECOLI octanol swissprot:SMP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SMP_ECOLI pepcoil swissprot:SMP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SMP_ECOLI pepdigest swissprot:SMP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SMP_ECOLI pepinfo swissprot:SMP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SMP_ECOLI pepnet swissprot:SMP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SMP_ECOLI pepstats swissprot:SMP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SMP_ECOLI pepwheel swissprot:SMP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SMP_ECOLI pepwindow swissprot:SMP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SMP_ECOLI sigcleave swissprot:SMP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SMP_ECOLI ## Database ID URL or Descriptions # EcoGene EG10884 rplX # FUNCTION RL24_ECOLI One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. {ECO 0000269|PubMed 16292303, ECO 0000269|PubMed 357435}. # FUNCTION RL24_ECOLI One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. It is not thought to be involved in the functions of the mature 50S subunit in vitro. {ECO 0000269|PubMed 3298242, ECO 0000269|PubMed 357435, ECO 0000269|PubMed 6760192}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0022625 cytosolic large ribosomal subunit; IDA:EcoCyc. # GO_function GO:0003735 structural constituent of ribosome; IEA:InterPro. # GO_function GO:0019843 rRNA binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006412 translation; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_function GO:0019843 rRNA binding # GOslim_process GO:0006412 translation # Gene3D 2.30.30.30 -; 1. # HAMAP MF_01326_B Ribosomal_L24_B # IntAct P60624 51 # InterPro IPR003256 Ribosomal_L24 # InterPro IPR005824 KOW # InterPro IPR005825 Ribosomal_L24/26_CS # InterPro IPR008991 Translation_prot_SH3-like # InterPro IPR014722 Rib_L2_dom2 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 M00179 Ribosome, archaea # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=11186.5; Method=MALDI; Range=2-104; Evidence={ECO:0000269|PubMed 10094780}; # Organism RL24_ECOLI Escherichia coli (strain K12) # PATRIC 32122050 VBIEscCol129921_3402 # PDB 1ML5 EM; 14.00 A; u=2-104 # PDB 2J28 EM; 8.00 A; U=2-103 # PDB 2RDO EM; 9.10 A; U=2-104 # PDB 2VRH EM; 19.00 A; C=2-104 # PDB 3BBX EM; 10.00 A; U=2-104 # PDB 3J45 EM; 9.50 A; U=2-104 # PDB 3J46 EM; 10.10 A; U=2-104 # PDB 3J5L EM; 6.60 A; U=2-103 # PDB 3J7Z EM; 3.90 A; U=1-104 # PDB 3J8G EM; 5.00 A; U=1-104 # PDB 3J9Y EM; 3.90 A; U=1-104 # PDB 3J9Z EM; 3.60 A; LS=2-104 # PDB 3JA1 EM; 3.60 A; LW=2-104 # PDB 3JBU EM; 3.64 A; u=1-104 # PDB 3JBV EM; 3.32 A; u=1-104 # PDB 3JCD EM; 3.70 A; U=1-104 # PDB 3JCE EM; 3.20 A; U=1-104 # PDB 3JCJ EM; 3.70 A; T=1-104 # PDB 3JCN EM; 4.60 A; U=1-104 # PDB 4CSU EM; 5.50 A; U=2-104 # PDB 4U1U X-ray; 2.95 A; BU/DU=2-103 # PDB 4U1V X-ray; 3.00 A; BU/DU=2-103 # PDB 4U20 X-ray; 2.90 A; BU/DU=2-103 # PDB 4U24 X-ray; 2.90 A; BU/DU=2-103 # PDB 4U25 X-ray; 2.90 A; BU/DU=2-103 # PDB 4U26 X-ray; 2.80 A; BU/DU=2-103 # PDB 4U27 X-ray; 2.80 A; BU/DU=2-103 # PDB 4UY8 EM; 3.80 A; U=2-103 # PDB 4V47 EM; 12.30 A; AS=2-104 # PDB 4V48 EM; 11.50 A; AS=2-104 # PDB 4V4H X-ray; 3.46 A; BU/DU=1-104 # PDB 4V4Q X-ray; 3.46 A; BU/DU=2-104 # PDB 4V4V EM; 15.00 A; BS=4-102 # PDB 4V4W EM; 15.00 A; BS=4-102 # PDB 4V50 X-ray; 3.22 A; BU/DU=2-104 # PDB 4V52 X-ray; 3.21 A; BU/DU=2-104 # PDB 4V53 X-ray; 3.54 A; BU/DU=2-104 # PDB 4V54 X-ray; 3.30 A; BU/DU=2-104 # PDB 4V55 X-ray; 4.00 A; BU/DU=2-104 # PDB 4V56 X-ray; 3.93 A; BU/DU=2-104 # PDB 4V57 X-ray; 3.50 A; BU/DU=2-104 # PDB 4V5B X-ray; 3.74 A; AU/CU=2-104 # PDB 4V5H EM; 5.80 A; BU=2-103 # PDB 4V5Y X-ray; 4.45 A; BU/DU=2-104 # PDB 4V64 X-ray; 3.50 A; BU/DU=2-104 # PDB 4V65 EM; 9.00 A; BO=1-103 # PDB 4V66 EM; 9.00 A; BO=1-103 # PDB 4V69 EM; 6.70 A; BU=2-103 # PDB 4V6C X-ray; 3.19 A; BU/DU=1-104 # PDB 4V6D X-ray; 3.81 A; BU/DU=1-104 # PDB 4V6E X-ray; 3.71 A; BU/DU=1-104 # PDB 4V6K EM; 8.25 A; AV=1-104 # PDB 4V6L EM; 13.20 A; BV=1-104 # PDB 4V6M EM; 7.10 A; BU=2-104 # PDB 4V6N EM; 12.10 A; AW=2-104 # PDB 4V6O EM; 14.70 A; BW=2-104 # PDB 4V6P EM; 13.50 A; BW=2-104 # PDB 4V6Q EM; 11.50 A; BW=2-104 # PDB 4V6R EM; 11.50 A; BW=2-104 # PDB 4V6S EM; 13.10 A; AW=2-104 # PDB 4V6T EM; 8.30 A; BU=2-103 # PDB 4V6V EM; 9.80 A; BY=2-104 # PDB 4V6Y EM; 12.00 A; BU=1-103 # PDB 4V6Z EM; 12.00 A; BU=1-103 # PDB 4V70 EM; 17.00 A; BU=1-103 # PDB 4V71 EM; 20.00 A; BU=1-103 # PDB 4V72 EM; 13.00 A; BU=1-103 # PDB 4V73 EM; 15.00 A; BU=1-103 # PDB 4V74 EM; 17.00 A; BU=1-103 # PDB 4V75 EM; 12.00 A; BU=1-103 # PDB 4V76 EM; 17.00 A; BU=1-103 # PDB 4V77 EM; 17.00 A; BU=1-103 # PDB 4V78 EM; 20.00 A; BU=1-103 # PDB 4V79 EM; 15.00 A; BU=1-103 # PDB 4V7A EM; 9.00 A; BU=1-103 # PDB 4V7B EM; 6.80 A; BU=1-104 # PDB 4V7C EM; 7.60 A; BW=2-104 # PDB 4V7D EM; 7.60 A; AX=2-104 # PDB 4V7I EM; 9.60 A; AU=1-104 # PDB 4V7S X-ray; 3.25 A; BU/DU=2-103 # PDB 4V7T X-ray; 3.19 A; BU/DU=2-103 # PDB 4V7U X-ray; 3.10 A; BU/DU=2-103 # PDB 4V7V X-ray; 3.29 A; BU/DU=2-103 # PDB 4V85 X-ray; 3.20 A; Y=1-104 # PDB 4V89 X-ray; 3.70 A; BY=1-104 # PDB 4V9C X-ray; 3.30 A; BU/DU=1-104 # PDB 4V9D X-ray; 3.00 A; CU/DU=2-103 # PDB 4V9O X-ray; 2.90 A; AU/CU/EU/GU=1-104 # PDB 4V9P X-ray; 2.90 A; AU/CU/EU/GU=1-104 # PDB 4WF1 X-ray; 3.09 A; BU/DU=2-103 # PDB 4WOI X-ray; 3.00 A; BU/CU=1-104 # PDB 4WWW X-ray; 3.10 A; RU/YU=2-103 # PDB 4YBB X-ray; 2.10 A; CV/DV=2-103 # PDB 5ADY EM; 4.50 A; U=1-104 # PDB 5AFI EM; 2.90 A; U=1-104 # PDB 5AKA EM; 5.70 A; U=2-104 # PDB 5GAD EM; 3.70 A; V=1-104 # PDB 5GAE EM; 3.33 A; V=1-104 # PDB 5GAF EM; 4.30 A; V=2-103 # PDB 5GAG EM; 3.80 A; V=1-104 # PDB 5GAH EM; 3.80 A; V=1-104 # PDB 5IQR EM; 3.00 A; U=1-104 # PDB 5IT8 X-ray; 3.12 A; CV/DV=2-103 # PDB 5J5B X-ray; 2.80 A; CV/DV=2-103 # PDB 5J7L X-ray; 3.00 A; CV/DV=2-103 # PDB 5J88 X-ray; 3.32 A; CV/DV=2-104 # PDB 5J8A X-ray; 3.10 A; CV/DV=2-104 # PDB 5J91 X-ray; 2.96 A; CV/DV=2-104 # PDB 5JC9 X-ray; 3.03 A; CV/DV=2-103 # PDB 5JTE EM; 3.60 A; BU=1-104 # PDB 5JU8 EM; 3.60 A; BU=1-104 # PDB 5KCR EM; 3.60 A; 1Y=1-104 # PDB 5KCS EM; 3.90 A; 1Y=1-104 # PDB 5KPS EM; 3.90 A; U=1-104 # PDB 5KPV EM; 4.10 A; T=1-104 # PDB 5KPW EM; 3.90 A; T=1-104 # PDB 5KPX EM; 3.90 A; T=1-104 # PDB 5L3P EM; 3.70 A; Y=1-104 # PIR H65123 R5EC24 # PROSITE PS01108 RIBOSOMAL_L24 # Pfam PF00467 KOW # Pfam PF17136 ribosomal_L24 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RL24_ECOLI 50S ribosomal protein L24 # RefSeq NP_417768 NC_000913.3 # RefSeq WP_000729185 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein L24P family. {ECO 0000305}. # SMART SM00739 KOW # SUBUNIT Part of the 50S ribosomal subunit. Might contact the SecYEG translocation complex when it is docked with the ribosome. {ECO:0000269|PubMed 16292303}. # SUPFAM SSF50104 SSF50104 # TIGRFAMs TIGR01079 rplX_bact # eggNOG COG0198 LUCA # eggNOG ENOG4105KAR Bacteria BLAST swissprot:RL24_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RL24_ECOLI BioCyc ECOL316407:JW3271-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3271-MONOMER BioCyc EcoCyc:EG10884-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10884-MONOMER BioCyc MetaCyc:EG10884-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10884-MONOMER COG COG0198 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0198 DIP DIP-47846N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47846N DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1016/0014-5793(79)81182-5 http://dx.doi.org/10.1016/0014-5793(79)81182-5 DOI 10.1016/S0092-8674(03)00427-6 http://dx.doi.org/10.1016/S0092-8674(03)00427-6 DOI 10.1016/j.celrep.2014.09.011 http://dx.doi.org/10.1016/j.celrep.2014.09.011 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature04133 http://dx.doi.org/10.1038/nature04133 DOI 10.1073/pnas.79.23.7238 http://dx.doi.org/10.1073/pnas.79.23.7238 DOI 10.1093/nar/11.9.2599 http://dx.doi.org/10.1093/nar/11.9.2599 DOI 10.1093/nar/9.7.1757 http://dx.doi.org/10.1093/nar/9.7.1757 DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pbio.1001866 http://dx.doi.org/10.1371/journal.pbio.1001866 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M10195 http://www.ebi.ac.uk/ena/data/view/M10195 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X01563 http://www.ebi.ac.uk/ena/data/view/X01563 EchoBASE EB0877 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0877 EcoGene EG10884 http://www.ecogene.org/geneInfo.php?eg_id=EG10884 EnsemblBacteria AAC76334 http://www.ensemblgenomes.org/id/AAC76334 EnsemblBacteria AAC76334 http://www.ensemblgenomes.org/id/AAC76334 EnsemblBacteria BAE77982 http://www.ensemblgenomes.org/id/BAE77982 EnsemblBacteria BAE77982 http://www.ensemblgenomes.org/id/BAE77982 EnsemblBacteria BAE77982 http://www.ensemblgenomes.org/id/BAE77982 EnsemblBacteria b3309 http://www.ensemblgenomes.org/id/b3309 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0022625 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022625 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 Gene3D 2.30.30.30 http://www.cathdb.info/version/latest/superfamily/2.30.30.30 GeneID 5548951 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5548951 GeneID 947810 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947810 HAMAP MF_01326_B http://hamap.expasy.org/unirule/MF_01326_B HOGENOM HOG000039892 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000039892&db=HOGENOM6 InParanoid P60624 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P60624 IntAct P60624 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P60624* InterPro IPR003256 http://www.ebi.ac.uk/interpro/entry/IPR003256 InterPro IPR005824 http://www.ebi.ac.uk/interpro/entry/IPR005824 InterPro IPR005825 http://www.ebi.ac.uk/interpro/entry/IPR005825 InterPro IPR008991 http://www.ebi.ac.uk/interpro/entry/IPR008991 InterPro IPR014722 http://www.ebi.ac.uk/interpro/entry/IPR014722 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW3271 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3271 KEGG_Gene eco:b3309 http://www.genome.jp/dbget-bin/www_bget?eco:b3309 KEGG_Orthology KO:K02895 http://www.genome.jp/dbget-bin/www_bget?KO:K02895 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 MINT MINT-1294921 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1294921 OMA NVAIFNQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NVAIFNQ PDB 1ML5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ML5 PDB 2J28 http://www.ebi.ac.uk/pdbe-srv/view/entry/2J28 PDB 2RDO http://www.ebi.ac.uk/pdbe-srv/view/entry/2RDO PDB 2VRH http://www.ebi.ac.uk/pdbe-srv/view/entry/2VRH PDB 3BBX http://www.ebi.ac.uk/pdbe-srv/view/entry/3BBX PDB 3J45 http://www.ebi.ac.uk/pdbe-srv/view/entry/3J45 PDB 3J46 http://www.ebi.ac.uk/pdbe-srv/view/entry/3J46 PDB 3J5L http://www.ebi.ac.uk/pdbe-srv/view/entry/3J5L PDB 3J7Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J7Z PDB 3J8G http://www.ebi.ac.uk/pdbe-srv/view/entry/3J8G PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 4CSU http://www.ebi.ac.uk/pdbe-srv/view/entry/4CSU PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4UY8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4UY8 PDB 4V47 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V47 PDB 4V48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V48 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5ADY http://www.ebi.ac.uk/pdbe-srv/view/entry/5ADY PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5AKA http://www.ebi.ac.uk/pdbe-srv/view/entry/5AKA PDB 5GAD http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAD PDB 5GAE http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAE PDB 5GAF http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAF PDB 5GAG http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAG PDB 5GAH http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAH PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 1ML5 http://www.ebi.ac.uk/pdbsum/1ML5 PDBsum 2J28 http://www.ebi.ac.uk/pdbsum/2J28 PDBsum 2RDO http://www.ebi.ac.uk/pdbsum/2RDO PDBsum 2VRH http://www.ebi.ac.uk/pdbsum/2VRH PDBsum 3BBX http://www.ebi.ac.uk/pdbsum/3BBX PDBsum 3J45 http://www.ebi.ac.uk/pdbsum/3J45 PDBsum 3J46 http://www.ebi.ac.uk/pdbsum/3J46 PDBsum 3J5L http://www.ebi.ac.uk/pdbsum/3J5L PDBsum 3J7Z http://www.ebi.ac.uk/pdbsum/3J7Z PDBsum 3J8G http://www.ebi.ac.uk/pdbsum/3J8G PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 4CSU http://www.ebi.ac.uk/pdbsum/4CSU PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4UY8 http://www.ebi.ac.uk/pdbsum/4UY8 PDBsum 4V47 http://www.ebi.ac.uk/pdbsum/4V47 PDBsum 4V48 http://www.ebi.ac.uk/pdbsum/4V48 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5ADY http://www.ebi.ac.uk/pdbsum/5ADY PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5AKA http://www.ebi.ac.uk/pdbsum/5AKA PDBsum 5GAD http://www.ebi.ac.uk/pdbsum/5GAD PDBsum 5GAE http://www.ebi.ac.uk/pdbsum/5GAE PDBsum 5GAF http://www.ebi.ac.uk/pdbsum/5GAF PDBsum 5GAG http://www.ebi.ac.uk/pdbsum/5GAG PDBsum 5GAH http://www.ebi.ac.uk/pdbsum/5GAH PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PROSITE PS01108 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01108 PSORT swissprot:RL24_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RL24_ECOLI PSORT-B swissprot:RL24_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RL24_ECOLI PSORT2 swissprot:RL24_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RL24_ECOLI Pfam PF00467 http://pfam.xfam.org/family/PF00467 Pfam PF17136 http://pfam.xfam.org/family/PF17136 Phobius swissprot:RL24_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RL24_ECOLI PhylomeDB P60624 http://phylomedb.org/?seqid=P60624 ProteinModelPortal P60624 http://www.proteinmodelportal.org/query/uniprot/P60624 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 12809609 http://www.ncbi.nlm.nih.gov/pubmed/12809609 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16292303 http://www.ncbi.nlm.nih.gov/pubmed/16292303 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 24844575 http://www.ncbi.nlm.nih.gov/pubmed/24844575 PubMed 25310980 http://www.ncbi.nlm.nih.gov/pubmed/25310980 PubMed 3298242 http://www.ncbi.nlm.nih.gov/pubmed/3298242 PubMed 357435 http://www.ncbi.nlm.nih.gov/pubmed/357435 PubMed 391595 http://www.ncbi.nlm.nih.gov/pubmed/391595 PubMed 6222285 http://www.ncbi.nlm.nih.gov/pubmed/6222285 PubMed 6262737 http://www.ncbi.nlm.nih.gov/pubmed/6262737 PubMed 6760192 http://www.ncbi.nlm.nih.gov/pubmed/6760192 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417768 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417768 RefSeq WP_000729185 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000729185 SMART SM00739 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00739 SMR P60624 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P60624 STRING 511145.b3309 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3309&targetmode=cogs STRING COG0198 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0198&targetmode=cogs SUPFAM SSF50104 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50104 TIGRFAMs TIGR01079 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01079 UniProtKB RL24_ECOLI http://www.uniprot.org/uniprot/RL24_ECOLI UniProtKB-AC P60624 http://www.uniprot.org/uniprot/P60624 charge swissprot:RL24_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RL24_ECOLI eggNOG COG0198 http://eggnogapi.embl.de/nog_data/html/tree/COG0198 eggNOG ENOG4105KAR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KAR epestfind swissprot:RL24_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RL24_ECOLI garnier swissprot:RL24_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RL24_ECOLI helixturnhelix swissprot:RL24_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RL24_ECOLI hmoment swissprot:RL24_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RL24_ECOLI iep swissprot:RL24_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RL24_ECOLI inforesidue swissprot:RL24_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RL24_ECOLI octanol swissprot:RL24_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RL24_ECOLI pepcoil swissprot:RL24_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RL24_ECOLI pepdigest swissprot:RL24_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RL24_ECOLI pepinfo swissprot:RL24_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RL24_ECOLI pepnet swissprot:RL24_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RL24_ECOLI pepstats swissprot:RL24_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RL24_ECOLI pepwheel swissprot:RL24_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RL24_ECOLI pepwindow swissprot:RL24_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RL24_ECOLI sigcleave swissprot:RL24_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RL24_ECOLI ## Database ID URL or Descriptions # AltName GSPI_ECOLI Putative general secretion pathway protein I # BioGrid 4259596 248 # EcoGene EG12892 gspI # FUNCTION GSPI_ECOLI Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. {ECO 0000305}. # GO_component GO:0015627 type II protein secretion system complex; IEA:InterPro. # GO_function GO:0008565 protein transporter activity; IEA:InterPro. # GO_process GO:0015628 protein secretion by the type II secretion system; IEA:InterPro. # GOslim_component GO:0043234 protein complex # GOslim_function GO:0008565 protein transporter activity # GOslim_process GO:0055085 transmembrane transport # INDUCTION Silenced by the DNA-binding protein H-NS under standard growth conditions. {ECO:0000269|PubMed 11118204}. # InterPro IPR003413 T2SS_protein-I_dom # InterPro IPR010052 T2SS_protein-I # InterPro IPR012902 N_methyl_site # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02044 M00331 Type II general secretion system # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko03070 Bacterial secretion system # MISCELLANEOUS GSPI_ECOLI Part of a cryptic operon that encodes proteins involved in type II secretion machinery in other organisms, but is not expressed in strain K12. # Organism GSPI_ECOLI Escherichia coli (strain K12) # PATRIC 32122092 VBIEscCol129921_3423 # PIR E65126 E65126 # PROSITE PS00409 PROKAR_NTER_METHYL # Pfam PF02501 T2SSI # Pfam PF07963 N_methyl # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GSPI_ECOLI Putative type II secretion system protein I # RefSeq NP_417789 NC_000913.3 # RefSeq WP_001041743 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA58127.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the GSP I family. {ECO 0000305}. # TIGRFAMs TIGR01707 gspI # TIGRFAMs TIGR02532 IV_pilin_GFxxxE # eggNOG COG2165 LUCA BLAST swissprot:GSPI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GSPI_ECOLI BioCyc ECOL316407:JW5706-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5706-MONOMER BioCyc EcoCyc:G7708-MONOMER http://biocyc.org/getid?id=EcoCyc:G7708-MONOMER BioCyc MetaCyc:G7708-MONOMER http://biocyc.org/getid?id=MetaCyc:G7708-MONOMER COG COG2165 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2165 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/emboj/19.24.6697 http://dx.doi.org/10.1093/emboj/19.24.6697 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2729 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2729 EcoGene EG12892 http://www.ecogene.org/geneInfo.php?eg_id=EG12892 EnsemblBacteria AAC76355 http://www.ensemblgenomes.org/id/AAC76355 EnsemblBacteria AAC76355 http://www.ensemblgenomes.org/id/AAC76355 EnsemblBacteria BAE77961 http://www.ensemblgenomes.org/id/BAE77961 EnsemblBacteria BAE77961 http://www.ensemblgenomes.org/id/BAE77961 EnsemblBacteria BAE77961 http://www.ensemblgenomes.org/id/BAE77961 EnsemblBacteria b3330 http://www.ensemblgenomes.org/id/b3330 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0015627 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015627 GO_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GO_process GO:0015628 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015628 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0008565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008565 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 947833 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947833 HOGENOM HOG000125364 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125364&db=HOGENOM6 InParanoid P45760 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45760 InterPro IPR003413 http://www.ebi.ac.uk/interpro/entry/IPR003413 InterPro IPR010052 http://www.ebi.ac.uk/interpro/entry/IPR010052 InterPro IPR012902 http://www.ebi.ac.uk/interpro/entry/IPR012902 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW5706 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5706 KEGG_Gene eco:b3330 http://www.genome.jp/dbget-bin/www_bget?eco:b3330 KEGG_Orthology KO:K02458 http://www.genome.jp/dbget-bin/www_bget?KO:K02458 KEGG_Pathway ko03070 http://www.genome.jp/kegg-bin/show_pathway?ko03070 PROSITE PS00409 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00409 PSORT swissprot:GSPI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GSPI_ECOLI PSORT-B swissprot:GSPI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GSPI_ECOLI PSORT2 swissprot:GSPI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GSPI_ECOLI Pfam PF02501 http://pfam.xfam.org/family/PF02501 Pfam PF07963 http://pfam.xfam.org/family/PF07963 Phobius swissprot:GSPI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GSPI_ECOLI PhylomeDB P45760 http://phylomedb.org/?seqid=P45760 ProteinModelPortal P45760 http://www.proteinmodelportal.org/query/uniprot/P45760 PubMed 11118204 http://www.ncbi.nlm.nih.gov/pubmed/11118204 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8655552 http://www.ncbi.nlm.nih.gov/pubmed/8655552 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417789 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417789 RefSeq WP_001041743 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001041743 STRING 511145.b3330 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3330&targetmode=cogs STRING COG2165 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2165&targetmode=cogs TIGRFAMs TIGR01707 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01707 TIGRFAMs TIGR02532 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02532 UniProtKB GSPI_ECOLI http://www.uniprot.org/uniprot/GSPI_ECOLI UniProtKB-AC P45760 http://www.uniprot.org/uniprot/P45760 charge swissprot:GSPI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GSPI_ECOLI eggNOG COG2165 http://eggnogapi.embl.de/nog_data/html/tree/COG2165 epestfind swissprot:GSPI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GSPI_ECOLI garnier swissprot:GSPI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GSPI_ECOLI helixturnhelix swissprot:GSPI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GSPI_ECOLI hmoment swissprot:GSPI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GSPI_ECOLI iep swissprot:GSPI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GSPI_ECOLI inforesidue swissprot:GSPI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GSPI_ECOLI octanol swissprot:GSPI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GSPI_ECOLI pepcoil swissprot:GSPI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GSPI_ECOLI pepdigest swissprot:GSPI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GSPI_ECOLI pepinfo swissprot:GSPI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GSPI_ECOLI pepnet swissprot:GSPI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GSPI_ECOLI pepstats swissprot:GSPI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GSPI_ECOLI pepwheel swissprot:GSPI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GSPI_ECOLI pepwindow swissprot:GSPI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GSPI_ECOLI sigcleave swissprot:GSPI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GSPI_ECOLI ## Database ID URL or Descriptions # BioGrid 4263031 16 # CAUTION Was originally called ecpD, but ecp is now used for the ecpABCDE operon involved in E.coli common pilus (ECP) synthesis. {ECO:0000305|PubMed 8102362}. # DISRUPTION PHENOTYPE Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain. {ECO:0000269|PubMed 20345943}. # EcoGene EG11973 yadV # FUNCTION YADV_ECOLI Part of the yadCKLM-htrE-yadVN fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. {ECO 0000269|PubMed 20345943}. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IEA:InterPro. # GO_process GO:0043711 pilus organization; IEA:InterPro. # GO_process GO:0061077 chaperone-mediated protein folding; IEA:InterPro. # GO_process GO:0071555 cell wall organization; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0006457 protein folding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 2.60.40.1070 -; 1. # Gene3D 2.60.40.360 -; 1. # INDUCTION YADV_ECOLI Repressed by H-NS. Induced by heat shock. {ECO 0000269|PubMed 20345943, ECO 0000269|PubMed 8102362}. # InterPro IPR001829 Pili_assmbl_chaperone_bac # InterPro IPR008962 PapD-like # InterPro IPR016147 Pili_assmbl_chaperone_N # InterPro IPR016148 Pili_assmbl_chaperone_C # InterPro IPR018046 Pili_assmbl_chaperone_CS # MISCELLANEOUS The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed. {ECO:0000305|PubMed 20345943}. # Organism YADV_ECOLI Escherichia coli (strain K12) # PATRIC 32115387 VBIEscCol129921_0145 # PIR S45209 S45209 # PRINTS PR00969 CHAPERONPILI # PROSITE PS00635 PILI_CHAPERONE # Pfam PF00345 PapD_N # Pfam PF02753 PapD_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YADV_ECOLI Probable fimbrial chaperone YadV # RefSeq NP_414682 NC_000913.3 # RefSeq WP_000465928 NZ_LN832404.1 # SIMILARITY Belongs to the periplasmic pilus chaperone family. {ECO 0000305}. # SIMILARITY Contains 1 Ig-like (immunoglobulin-like) domain. {ECO 0000305}. # SUBCELLULAR LOCATION YADV_ECOLI Periplasm {ECO 0000250}. # SUPFAM SSF49354 SSF49354 # SUPFAM SSF49584 SSF49584 # eggNOG ENOG4108VEV Bacteria # eggNOG ENOG4111JH1 LUCA BLAST swissprot:YADV_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YADV_ECOLI BioCyc ECOL316407:JW0136-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0136-MONOMER BioCyc EcoCyc:EG11973-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11973-MONOMER COG COG3121 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3121 DIP DIP-9492N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9492N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1111/j.1462-2920.2010.02202.x http://dx.doi.org/10.1111/j.1462-2920.2010.02202.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L00680 http://www.ebi.ac.uk/ena/data/view/L00680 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1916 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1916 EcoGene EG11973 http://www.ecogene.org/geneInfo.php?eg_id=EG11973 EnsemblBacteria AAC73251 http://www.ensemblgenomes.org/id/AAC73251 EnsemblBacteria AAC73251 http://www.ensemblgenomes.org/id/AAC73251 EnsemblBacteria BAB96716 http://www.ensemblgenomes.org/id/BAB96716 EnsemblBacteria BAB96716 http://www.ensemblgenomes.org/id/BAB96716 EnsemblBacteria BAB96716 http://www.ensemblgenomes.org/id/BAB96716 EnsemblBacteria b0140 http://www.ensemblgenomes.org/id/b0140 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_process GO:0043711 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043711 GO_process GO:0061077 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061077 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 2.60.40.1070 http://www.cathdb.info/version/latest/superfamily/2.60.40.1070 Gene3D 2.60.40.360 http://www.cathdb.info/version/latest/superfamily/2.60.40.360 GeneID 944859 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944859 HOGENOM HOG000260152 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260152&db=HOGENOM6 InParanoid P33128 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33128 IntAct P33128 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33128* InterPro IPR001829 http://www.ebi.ac.uk/interpro/entry/IPR001829 InterPro IPR008962 http://www.ebi.ac.uk/interpro/entry/IPR008962 InterPro IPR016147 http://www.ebi.ac.uk/interpro/entry/IPR016147 InterPro IPR016148 http://www.ebi.ac.uk/interpro/entry/IPR016148 InterPro IPR018046 http://www.ebi.ac.uk/interpro/entry/IPR018046 KEGG_Gene ecj:JW0136 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0136 KEGG_Gene eco:b0140 http://www.genome.jp/dbget-bin/www_bget?eco:b0140 KEGG_Orthology KO:K15540 http://www.genome.jp/dbget-bin/www_bget?KO:K15540 MINT MINT-1302192 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1302192 OMA DQKSVSV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DQKSVSV PRINTS PR00969 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00969 PROSITE PS00635 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00635 PSORT swissprot:YADV_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YADV_ECOLI PSORT-B swissprot:YADV_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YADV_ECOLI PSORT2 swissprot:YADV_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YADV_ECOLI Pfam PF00345 http://pfam.xfam.org/family/PF00345 Pfam PF02753 http://pfam.xfam.org/family/PF02753 Phobius swissprot:YADV_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YADV_ECOLI PhylomeDB P33128 http://phylomedb.org/?seqid=P33128 ProteinModelPortal P33128 http://www.proteinmodelportal.org/query/uniprot/P33128 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20345943 http://www.ncbi.nlm.nih.gov/pubmed/20345943 PubMed 8102362 http://www.ncbi.nlm.nih.gov/pubmed/8102362 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414682 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414682 RefSeq WP_000465928 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000465928 SMR P33128 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33128 STRING 511145.b0140 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0140&targetmode=cogs STRING COG3121 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3121&targetmode=cogs SUPFAM SSF49354 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49354 SUPFAM SSF49584 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49584 UniProtKB YADV_ECOLI http://www.uniprot.org/uniprot/YADV_ECOLI UniProtKB-AC P33128 http://www.uniprot.org/uniprot/P33128 charge swissprot:YADV_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YADV_ECOLI eggNOG ENOG4108VEV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108VEV eggNOG ENOG4111JH1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111JH1 epestfind swissprot:YADV_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YADV_ECOLI garnier swissprot:YADV_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YADV_ECOLI helixturnhelix swissprot:YADV_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YADV_ECOLI hmoment swissprot:YADV_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YADV_ECOLI iep swissprot:YADV_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YADV_ECOLI inforesidue swissprot:YADV_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YADV_ECOLI octanol swissprot:YADV_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YADV_ECOLI pepcoil swissprot:YADV_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YADV_ECOLI pepdigest swissprot:YADV_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YADV_ECOLI pepinfo swissprot:YADV_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YADV_ECOLI pepnet swissprot:YADV_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YADV_ECOLI pepstats swissprot:YADV_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YADV_ECOLI pepwheel swissprot:YADV_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YADV_ECOLI pepwindow swissprot:YADV_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YADV_ECOLI sigcleave swissprot:YADV_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YADV_ECOLI ## Database ID URL or Descriptions # AltName NINE_ECOLI Protein NinE homolog from lambdoid prophage DLP12 # BioGrid 4259877 141 # EcoGene EG14286 ninE # IntAct Q47270 3 # MISCELLANEOUS NINE_ECOLI Encoded by the cryptic lambdoid prophage DLP12. # Organism NINE_ECOLI Escherichia coli (strain K12) # PIR S66588 S66588 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Prophage NinE homolog {ECO 0000305} # RefSeq NP_415080 NC_000913.3 # RefSeq WP_000224915 NZ_LN832404.1 # SIMILARITY Belongs to the ninE family. {ECO 0000305}. # eggNOG ENOG410757E Bacteria # eggNOG ENOG410ZDTG LUCA BLAST swissprot:NINE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NINE_ECOLI BioCyc ECOL316407:JW0536-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0536-MONOMER BioCyc EcoCyc:G6304-MONOMER http://biocyc.org/getid?id=EcoCyc:G6304-MONOMER DOI 10.1006/jmbi.1996.0185 http://dx.doi.org/10.1006/jmbi.1996.0185 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X92587 http://www.ebi.ac.uk/ena/data/view/X92587 EchoBASE EB4034 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4034 EcoGene EG14286 http://www.ecogene.org/geneInfo.php?eg_id=EG14286 EnsemblBacteria AAC73649 http://www.ensemblgenomes.org/id/AAC73649 EnsemblBacteria AAC73649 http://www.ensemblgenomes.org/id/AAC73649 EnsemblBacteria BAE76323 http://www.ensemblgenomes.org/id/BAE76323 EnsemblBacteria BAE76323 http://www.ensemblgenomes.org/id/BAE76323 EnsemblBacteria BAE76323 http://www.ensemblgenomes.org/id/BAE76323 EnsemblBacteria b0548 http://www.ensemblgenomes.org/id/b0548 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945151 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945151 HOGENOM HOG000054897 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000054897&db=HOGENOM6 IntAct Q47270 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q47270* KEGG_Gene ecj:JW0536 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0536 KEGG_Gene eco:b0548 http://www.genome.jp/dbget-bin/www_bget?eco:b0548 OMA VDQKWLR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VDQKWLR PSORT swissprot:NINE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NINE_ECOLI PSORT-B swissprot:NINE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NINE_ECOLI PSORT2 swissprot:NINE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NINE_ECOLI Phobius swissprot:NINE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NINE_ECOLI ProteinModelPortal Q47270 http://www.proteinmodelportal.org/query/uniprot/Q47270 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8648624 http://www.ncbi.nlm.nih.gov/pubmed/8648624 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415080 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415080 RefSeq WP_000224915 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000224915 STRING 511145.b0548 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0548&targetmode=cogs UniProtKB NINE_ECOLI http://www.uniprot.org/uniprot/NINE_ECOLI UniProtKB-AC Q47270 http://www.uniprot.org/uniprot/Q47270 charge swissprot:NINE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NINE_ECOLI eggNOG ENOG410757E http://eggnogapi.embl.de/nog_data/html/tree/ENOG410757E eggNOG ENOG410ZDTG http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZDTG epestfind swissprot:NINE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NINE_ECOLI garnier swissprot:NINE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NINE_ECOLI helixturnhelix swissprot:NINE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NINE_ECOLI hmoment swissprot:NINE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NINE_ECOLI iep swissprot:NINE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NINE_ECOLI inforesidue swissprot:NINE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NINE_ECOLI octanol swissprot:NINE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NINE_ECOLI pepcoil swissprot:NINE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NINE_ECOLI pepdigest swissprot:NINE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NINE_ECOLI pepinfo swissprot:NINE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NINE_ECOLI pepnet swissprot:NINE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NINE_ECOLI pepstats swissprot:NINE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NINE_ECOLI pepwheel swissprot:NINE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NINE_ECOLI pepwindow swissprot:NINE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NINE_ECOLI sigcleave swissprot:NINE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NINE_ECOLI ## Database ID URL or Descriptions # AltName ILVM_ECOLI ALS-II # AltName ILVM_ECOLI Acetohydroxy-acid synthase II small subunit # BioGrid 4263292 7 # CATALYTIC ACTIVITY ILVM_ECOLI 2 pyruvate = 2-acetolactate + CO(2). # COFACTOR ILVM_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250}; Note=Binds 1 Mg(2+) ion per subunit. {ECO 0000250}; # COFACTOR ILVM_ECOLI Name=thiamine diphosphate; Xref=ChEBI CHEBI 58937; Evidence={ECO 0000250}; Note=Binds 1 thiamine pyrophosphate per subunit. {ECO 0000250}; # EcoGene EG10501 ilvM # GO_function GO:0003984 acetolactate synthase activity; IDA:EcoCyc. # GO_function GO:0016597 amino acid binding; IEA:InterPro. # GO_process GO:0008652 cellular amino acid biosynthetic process; IDA:EcoCyc. # GO_process GO:0009097 isoleucine biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0009099 valine biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # IntAct P0ADG1 3 # InterPro IPR002912 ACT_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00290 Valine, leucine and isoleucine biosynthesis # KEGG_Pathway ko00650 Butanoate metabolism # KEGG_Pathway ko00660 C5-Branched dibasic acid metabolism # KEGG_Pathway ko00770 Pantothenate and CoA biosynthesis # MISCELLANEOUS E.coli contains genes for 3 AHAS isozymes ilvBN, ilvGM and ilvIH. # Organism ILVM_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-isoleucine biosynthesis; L- isoleucine from 2-oxobutanoate step 1/4. # PATHWAY Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate step 1/4. # PATRIC 32123033 VBIEscCol129921_3886 # PROSITE PS51671 ACT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ILVM_ECOLI Acetolactate synthase isozyme 2 small subunit # RefSeq NP_418217 NC_000913.3 # RefSeq WP_000983255 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB59051.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA26261.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Contains 1 ACT domain. {ECO:0000255|PROSITE- ProRule PRU01007}. # SUBUNIT ILVM_ECOLI Tetramer of two large and two small chains. # UniPathway UPA00047 UER00055 # UniPathway UPA00049 UER00059 # eggNOG COG3978 LUCA # eggNOG ENOG4105P3Y Bacteria BLAST swissprot:ILVM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ILVM_ECOLI BioCyc ECOL316407:JW3742-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3742-MONOMER BioCyc EcoCyc:SMALLILVM-MONOMER http://biocyc.org/getid?id=EcoCyc:SMALLILVM-MONOMER BioCyc MetaCyc:SMALLILVM-MONOMER http://biocyc.org/getid?id=MetaCyc:SMALLILVM-MONOMER COG COG3978 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3978 DOI 10.1016/0022-2836(92)90460-2 http://dx.doi.org/10.1016/0022-2836(92)90460-2 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/15.5.2137 http://dx.doi.org/10.1093/nar/15.5.2137 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.2.1.6 http://www.genome.jp/dbget-bin/www_bget?EC:2.2.1.6 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M10313 http://www.ebi.ac.uk/ena/data/view/M10313 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X02413 http://www.ebi.ac.uk/ena/data/view/X02413 EMBL X04890 http://www.ebi.ac.uk/ena/data/view/X04890 ENZYME 2.2.1.6 http://enzyme.expasy.org/EC/2.2.1.6 EchoBASE EB0496 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0496 EcoGene EG10501 http://www.ecogene.org/geneInfo.php?eg_id=EG10501 EnsemblBacteria AAC77489 http://www.ensemblgenomes.org/id/AAC77489 EnsemblBacteria AAC77489 http://www.ensemblgenomes.org/id/AAC77489 EnsemblBacteria BAE77528 http://www.ensemblgenomes.org/id/BAE77528 EnsemblBacteria BAE77528 http://www.ensemblgenomes.org/id/BAE77528 EnsemblBacteria BAE77528 http://www.ensemblgenomes.org/id/BAE77528 EnsemblBacteria b3769 http://www.ensemblgenomes.org/id/b3769 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003984 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003984 GO_function GO:0016597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016597 GO_process GO:0008652 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008652 GO_process GO:0009097 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009097 GO_process GO:0009099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009099 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 948279 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948279 HOGENOM HOG000286146 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000286146&db=HOGENOM6 IntAct P0ADG1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADG1* IntEnz 2.2.1.6 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.2.1.6 InterPro IPR002912 http://www.ebi.ac.uk/interpro/entry/IPR002912 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3742 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3742 KEGG_Gene eco:b3769 http://www.genome.jp/dbget-bin/www_bget?eco:b3769 KEGG_Orthology KO:K11258 http://www.genome.jp/dbget-bin/www_bget?KO:K11258 KEGG_Pathway ko00290 http://www.genome.jp/kegg-bin/show_pathway?ko00290 KEGG_Pathway ko00650 http://www.genome.jp/kegg-bin/show_pathway?ko00650 KEGG_Pathway ko00660 http://www.genome.jp/kegg-bin/show_pathway?ko00660 KEGG_Pathway ko00770 http://www.genome.jp/kegg-bin/show_pathway?ko00770 KEGG_Reaction rn:R00014 http://www.genome.jp/dbget-bin/www_bget?rn:R00014 KEGG_Reaction rn:R04672 http://www.genome.jp/dbget-bin/www_bget?rn:R04672 KEGG_Reaction rn:R04673 http://www.genome.jp/dbget-bin/www_bget?rn:R04673 KEGG_Reaction rn:R08648 http://www.genome.jp/dbget-bin/www_bget?rn:R08648 OMA TRHRGFQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TRHRGFQ PROSITE PS51671 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51671 PSORT swissprot:ILVM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ILVM_ECOLI PSORT-B swissprot:ILVM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ILVM_ECOLI PSORT2 swissprot:ILVM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ILVM_ECOLI Phobius swissprot:ILVM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ILVM_ECOLI ProteinModelPortal P0ADG1 http://www.proteinmodelportal.org/query/uniprot/P0ADG1 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 1569580 http://www.ncbi.nlm.nih.gov/pubmed/1569580 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3550695 http://www.ncbi.nlm.nih.gov/pubmed/3550695 PubMed 3897211 http://www.ncbi.nlm.nih.gov/pubmed/3897211 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418217 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418217 RefSeq WP_000983255 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000983255 STRING 511145.b3769 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3769&targetmode=cogs STRING COG3978 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3978&targetmode=cogs UniProtKB ILVM_ECOLI http://www.uniprot.org/uniprot/ILVM_ECOLI UniProtKB-AC P0ADG1 http://www.uniprot.org/uniprot/P0ADG1 charge swissprot:ILVM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ILVM_ECOLI eggNOG COG3978 http://eggnogapi.embl.de/nog_data/html/tree/COG3978 eggNOG ENOG4105P3Y http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105P3Y epestfind swissprot:ILVM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ILVM_ECOLI garnier swissprot:ILVM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ILVM_ECOLI helixturnhelix swissprot:ILVM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ILVM_ECOLI hmoment swissprot:ILVM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ILVM_ECOLI iep swissprot:ILVM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ILVM_ECOLI inforesidue swissprot:ILVM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ILVM_ECOLI octanol swissprot:ILVM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ILVM_ECOLI pepcoil swissprot:ILVM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ILVM_ECOLI pepdigest swissprot:ILVM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ILVM_ECOLI pepinfo swissprot:ILVM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ILVM_ECOLI pepnet swissprot:ILVM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ILVM_ECOLI pepstats swissprot:ILVM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ILVM_ECOLI pepwheel swissprot:ILVM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ILVM_ECOLI pepwindow swissprot:ILVM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ILVM_ECOLI sigcleave swissprot:ILVM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ILVM_ECOLI ## Database ID URL or Descriptions # AltName NUDI_ECOLI dCTP diphosphatase # AltName NUDI_ECOLI dTTP diphosphatase # AltName NUDI_ECOLI dUTP diphosphatase # AltName Nucleotide diphosphatase NudI {ECO:0000255|HAMAP-Rule MF_01846} # AltName Pyrimidine deoxynucleoside triphosphate diphosphatase {ECO 0000305} # BIOPHYSICOCHEMICAL PROPERTIES NUDI_ECOLI Kinetic parameters KM=2.2 mM for dUTP {ECO 0000269|PubMed 16766526}; KM=1.3 mM for dTTP {ECO 0000269|PubMed 16766526}; Vmax=81 umol/min/mg enzyme with dUTP as substrate {ECO 0000269|PubMed 16766526}; Vmax=56 umol/min/mg enzyme with dTTP as substrate {ECO 0000269|PubMed 16766526}; Note=kcat is 21 sec(-1) with dUTP as substrate, and 15 sec(-1) with dTTP as substrate. {ECO 0000269|PubMed 16766526}; pH dependence Optimum pH is about 8.5. {ECO 0000269|PubMed 16766526}; # BioGrid 4261215 13 # CATALYTIC ACTIVITY A nucleoside triphosphate + H(2)O = a nucleotide + diphosphate. {ECO:0000269|PubMed 16766526}. # CATALYTIC ACTIVITY dCTP + H(2)O = dCMP + diphosphate. {ECO:0000269|PubMed 16766526}. # CATALYTIC ACTIVITY dTTP + H(2)O = dTMP + diphosphate. {ECO:0000269|PubMed 16766526}. # CATALYTIC ACTIVITY dUTP + H(2)O = dUMP + diphosphate. {ECO:0000269|PubMed 16766526}. # COFACTOR NUDI_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 16766526}; # EcoGene EG13275 nudI # FUNCTION NUDI_ECOLI Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP). {ECO 0000269|PubMed 16766526}. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0004170 dUTP diphosphatase activity; IDA:EcoCyc. # GO_function GO:0035529 NADH pyrophosphatase activity; IEA:UniProtKB-EC. # GO_function GO:0047840 dCTP diphosphatase activity; IDA:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # Gene3D 3.90.79.10 -; 1. # HAMAP MF_01846 Nudix_NudI # IntAct P52006 7 # InterPro IPR000086 NUDIX_hydrolase_dom # InterPro IPR015797 NUDIX_hydrolase_dom-like # InterPro IPR020084 NUDIX_hydrolase_CS # InterPro IPR020476 Nudix_hydrolase # InterPro IPR023781 Nucleoside_triphosphatase_NudI # KEGG_Brite ko01000 Enzymes # Organism NUDI_ECOLI Escherichia coli (strain K12) # PATRIC 32119867 VBIEscCol129921_2343 # PIR A64996 A64996 # PRINTS PR00502 NUDIXFAMILY # PROSITE PS00893 NUDIX_BOX # PROSITE PS51462 NUDIX # Pfam PF00293 NUDIX # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Nucleoside triphosphatase NudI {ECO:0000303|PubMed 16766526} # RefSeq NP_416754 NC_000913.3 # RefSeq WP_001300564 NZ_LN832404.1 # SIMILARITY Belongs to the Nudix hydrolase family. NudI subfamily. {ECO 0000305}. # SIMILARITY Contains 1 nudix hydrolase domain. {ECO 0000305}. # SUBUNIT Monomer. {ECO:0000269|PubMed 16766526}. # SUPFAM SSF55811 SSF55811 # eggNOG COG0494 LUCA # eggNOG ENOG4108RJ7 Bacteria BLAST swissprot:NUDI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NUDI_ECOLI BioCyc ECOL316407:JW2245-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2245-MONOMER BioCyc EcoCyc:G7164-MONOMER http://biocyc.org/getid?id=EcoCyc:G7164-MONOMER BioCyc MetaCyc:G7164-MONOMER http://biocyc.org/getid?id=MetaCyc:G7164-MONOMER COG COG0494 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0494 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M603407200 http://dx.doi.org/10.1074/jbc.M603407200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1107/S1744309107040316 http://dx.doi.org/10.1107/S1744309107040316 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.1.- {ECO:0000269|PubMed:16766526} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.1.- {ECO:0000269|PubMed:16766526} EC_number EC:3.6.1.12 {ECO:0000269|PubMed:16766526} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.1.12 {ECO:0000269|PubMed:16766526} EC_number EC:3.6.1.23 {ECO:0000269|PubMed:16766526} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.1.23 {ECO:0000269|PubMed:16766526} EC_number EC:3.6.1.9 {ECO:0000269|PubMed:16766526} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.1.9 {ECO:0000269|PubMed:16766526} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X83874 http://www.ebi.ac.uk/ena/data/view/X83874 ENZYME 3.6.1.- {ECO:0000269|PubMed:16766526} http://enzyme.expasy.org/EC/3.6.1.- {ECO:0000269|PubMed:16766526} ENZYME 3.6.1.12 {ECO:0000269|PubMed:16766526} http://enzyme.expasy.org/EC/3.6.1.12 {ECO:0000269|PubMed:16766526} ENZYME 3.6.1.23 {ECO:0000269|PubMed:16766526} http://enzyme.expasy.org/EC/3.6.1.23 {ECO:0000269|PubMed:16766526} ENZYME 3.6.1.9 {ECO:0000269|PubMed:16766526} http://enzyme.expasy.org/EC/3.6.1.9 {ECO:0000269|PubMed:16766526} EchoBASE EB3060 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3060 EcoGene EG13275 http://www.ecogene.org/geneInfo.php?eg_id=EG13275 EnsemblBacteria AAC75311 http://www.ensemblgenomes.org/id/AAC75311 EnsemblBacteria AAC75311 http://www.ensemblgenomes.org/id/AAC75311 EnsemblBacteria BAA16074 http://www.ensemblgenomes.org/id/BAA16074 EnsemblBacteria BAA16074 http://www.ensemblgenomes.org/id/BAA16074 EnsemblBacteria BAA16074 http://www.ensemblgenomes.org/id/BAA16074 EnsemblBacteria b2251 http://www.ensemblgenomes.org/id/b2251 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0004170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004170 GO_function GO:0035529 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035529 GO_function GO:0047840 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047840 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.90.79.10 http://www.cathdb.info/version/latest/superfamily/3.90.79.10 GeneID 946740 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946740 HAMAP MF_01846 http://hamap.expasy.org/unirule/MF_01846 HOGENOM HOG000059287 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000059287&db=HOGENOM6 InParanoid P52006 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P52006 IntAct P52006 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P52006* IntEnz 3.6.1.- {ECO:0000269|PubMed:16766526} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.1.- {ECO:0000269|PubMed:16766526} IntEnz 3.6.1.12 {ECO:0000269|PubMed:16766526} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.1.12 {ECO:0000269|PubMed:16766526} IntEnz 3.6.1.23 {ECO:0000269|PubMed:16766526} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.1.23 {ECO:0000269|PubMed:16766526} IntEnz 3.6.1.9 {ECO:0000269|PubMed:16766526} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.1.9 {ECO:0000269|PubMed:16766526} InterPro IPR000086 http://www.ebi.ac.uk/interpro/entry/IPR000086 InterPro IPR015797 http://www.ebi.ac.uk/interpro/entry/IPR015797 InterPro IPR020084 http://www.ebi.ac.uk/interpro/entry/IPR020084 InterPro IPR020476 http://www.ebi.ac.uk/interpro/entry/IPR020476 InterPro IPR023781 http://www.ebi.ac.uk/interpro/entry/IPR023781 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2245 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2245 KEGG_Gene eco:b2251 http://www.genome.jp/dbget-bin/www_bget?eco:b2251 KEGG_Orthology KO:K12944 http://www.genome.jp/dbget-bin/www_bget?KO:K12944 MINT MINT-1262923 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1262923 OMA NEEFDDY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NEEFDDY PRINTS PR00502 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00502 PROSITE PS00893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00893 PROSITE PS51462 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51462 PSORT swissprot:NUDI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NUDI_ECOLI PSORT-B swissprot:NUDI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NUDI_ECOLI PSORT2 swissprot:NUDI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NUDI_ECOLI Pfam PF00293 http://pfam.xfam.org/family/PF00293 Phobius swissprot:NUDI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NUDI_ECOLI ProteinModelPortal P52006 http://www.proteinmodelportal.org/query/uniprot/P52006 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16766526 http://www.ncbi.nlm.nih.gov/pubmed/16766526 PubMed 17768363 http://www.ncbi.nlm.nih.gov/pubmed/17768363 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416754 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416754 RefSeq WP_001300564 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300564 SMR P52006 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P52006 STRING 511145.b2251 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2251&targetmode=cogs STRING COG0494 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0494&targetmode=cogs SUPFAM SSF55811 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55811 UniProtKB NUDI_ECOLI http://www.uniprot.org/uniprot/NUDI_ECOLI UniProtKB-AC P52006 http://www.uniprot.org/uniprot/P52006 charge swissprot:NUDI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NUDI_ECOLI eggNOG COG0494 http://eggnogapi.embl.de/nog_data/html/tree/COG0494 eggNOG ENOG4108RJ7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108RJ7 epestfind swissprot:NUDI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NUDI_ECOLI garnier swissprot:NUDI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NUDI_ECOLI helixturnhelix swissprot:NUDI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NUDI_ECOLI hmoment swissprot:NUDI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NUDI_ECOLI iep swissprot:NUDI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NUDI_ECOLI inforesidue swissprot:NUDI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NUDI_ECOLI octanol swissprot:NUDI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NUDI_ECOLI pepcoil swissprot:NUDI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NUDI_ECOLI pepdigest swissprot:NUDI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NUDI_ECOLI pepinfo swissprot:NUDI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NUDI_ECOLI pepnet swissprot:NUDI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NUDI_ECOLI pepstats swissprot:NUDI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NUDI_ECOLI pepwheel swissprot:NUDI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NUDI_ECOLI pepwindow swissprot:NUDI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NUDI_ECOLI sigcleave swissprot:NUDI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NUDI_ECOLI ## Database ID URL or Descriptions # AltName Kdo(2)-lauroyl-lipid IV(A) myristoyltransferase {ECO:0000255|HAMAP-Rule MF_01944} # BRENDA 2.3.1.B31 2026 # BioGrid 4260351 224 # CATALYTIC ACTIVITY A tetradecanoyl-[acyl-carrier protein] + Kdo(2)-(palmitoleoyl)-lipid IVA = Kdo(2)-lipid A, cold adapted + a holo-[acyl-carrier protein]. {ECO:0000305|PubMed 10092655}. # CATALYTIC ACTIVITY LPXM_ECOLI A tetradecanoyl-[acyl-carrier protein] + (Kdo)(2)-(dodecanoyl)-lipid IV(A) = Kdo(2)-lipid A + a holo-[acyl- carrier protein]. {ECO 0000255|HAMAP-Rule MF_01944, ECO 0000269|PubMed 9099672}. # CAUTION Was originally thought to be the membrane-bound lytic murein transglycosylase (MLT). {ECO:0000305|PubMed 1356966}. # CDD cd07984 LPLAT_LABLAT-like # DISRUPTION PHENOTYPE Makes pentaacylated lipid A rather than the usual hexaacylated lipid A. {ECO:0000269|PubMed 16467300}. # EcoGene EG10614 lpxM # FUNCTION LPXM_ECOLI Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)-lipid A. Can probably also catalyze the transfer of myristate to Kdo(2)-(palmitoleoyl)-lipid IV(A) to form the cold- adapted Kdo(2)-lipid A. In vitro, can acylate Kdo(2)-lipid IV(A), but acylation of (KDO)2-(lauroyl)-lipid IV(A) is about 100 times faster. In vitro, can use lauroyl-ACP but displays a slight kinetic preference for myristoyl-ACP. {ECO 0000269|PubMed 9099672, ECO 0000305|PubMed 10092655}. # GO_component GO:0005887 integral component of plasma membrane; IEA:UniProtKB-HAMAP. # GO_component GO:0009276 Gram-negative-bacterium-type cell wall; IEA:InterPro. # GO_function GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups; IDA:EcoCyc. # GO_function GO:0019107 myristoyltransferase activity; IEA:UniProtKB-HAMAP. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0036104 Kdo2-lipid A biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005618 cell wall # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # HAMAP MF_01944 Lipid_A_LpxM # IntAct P24205 21 # InterPro IPR004960 LipA_acyltrans # InterPro IPR011921 Lipid_A_MsbB # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # KEGG_Pathway ko00540 Lipopolysaccharide biosynthesis # Organism LPXM_ECOLI Escherichia coli (strain K12) # PATHWAY LPXM_ECOLI Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. {ECO 0000255|HAMAP-Rule MF_01944, ECO 0000269|PubMed 9099672, ECO 0000305|PubMed 10092655}. # PATHWAY LPXM_ECOLI Glycolipid biosynthesis; KDO(2)-lipid A biosynthesis; KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A) step 4/4. {ECO 0000255|HAMAP-Rule MF_01944, ECO 0000269|PubMed 9099672, ECO 0000305|PubMed 10092655}. # PATRIC 32119033 VBIEscCol129921_1934 # PIR A42608 A42608 # PIRSF PIRSF026649 MsbB # Pfam PF03279 Lip_A_acyltrans # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Lipid A biosynthesis myristoyltransferase {ECO:0000255|HAMAP-Rule MF_01944, ECO:0000305} # RefSeq NP_416369 NC_000913.3 # RefSeq WP_000448381 NZ_LN832404.1 # SIMILARITY Belongs to the LpxL/LpxM/LpxP family. LpxM subfamily. {ECO:0000255|HAMAP-Rule MF_01944, ECO:0000305}. # SUBCELLULAR LOCATION LPXM_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01944, ECO 0000269|PubMed 9099672}; Single-pass membrane protein {ECO 0000255|HAMAP-Rule MF_01944}. # TIGRFAMs TIGR02208 lipid_A_msbB # UniPathway UPA00360 UER00486 # eggNOG COG1560 LUCA # eggNOG ENOG4105NWR Bacteria BLAST swissprot:LPXM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LPXM_ECOLI BioCyc ECOL316407:JW1844-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1844-MONOMER BioCyc EcoCyc:MYRISTOYLACYLTRAN-MONOMER http://biocyc.org/getid?id=EcoCyc:MYRISTOYLACYLTRAN-MONOMER BioCyc MetaCyc:MYRISTOYLACYLTRAN-MONOMER http://biocyc.org/getid?id=MetaCyc:MYRISTOYLACYLTRAN-MONOMER COG COG1560 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1560 DIP DIP-10262N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10262N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.272.16.10353 http://dx.doi.org/10.1074/jbc.272.16.10353 DOI 10.1074/jbc.274.14.9677 http://dx.doi.org/10.1074/jbc.274.14.9677 DOI 10.1074/jbc.M600435200 http://dx.doi.org/10.1074/jbc.M600435200 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.243 {ECO:0000255|HAMAP-Rule:MF_01944, ECO:0000269|PubMed:9099672, ECO:0000305|PubMed:10092655} http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.243 {ECO:0000255|HAMAP-Rule:MF_01944, ECO:0000269|PubMed:9099672, ECO:0000305|PubMed:10092655} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M77039 http://www.ebi.ac.uk/ena/data/view/M77039 EMBL M87660 http://www.ebi.ac.uk/ena/data/view/M87660 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.3.1.243 {ECO:0000255|HAMAP-Rule:MF_01944, ECO:0000269|PubMed:9099672, ECO:0000305|PubMed:10092655} http://enzyme.expasy.org/EC/2.3.1.243 {ECO:0000255|HAMAP-Rule:MF_01944, ECO:0000269|PubMed:9099672, ECO:0000305|PubMed:10092655} EchoBASE EB0609 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0609 EcoGene EG10614 http://www.ecogene.org/geneInfo.php?eg_id=EG10614 EnsemblBacteria AAC74925 http://www.ensemblgenomes.org/id/AAC74925 EnsemblBacteria AAC74925 http://www.ensemblgenomes.org/id/AAC74925 EnsemblBacteria BAA15663 http://www.ensemblgenomes.org/id/BAA15663 EnsemblBacteria BAA15663 http://www.ensemblgenomes.org/id/BAA15663 EnsemblBacteria BAA15663 http://www.ensemblgenomes.org/id/BAA15663 EnsemblBacteria b1855 http://www.ensemblgenomes.org/id/b1855 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0009276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009276 GO_function GO:0016747 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016747 GO_function GO:0019107 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019107 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GO_process GO:0036104 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036104 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005618 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 945143 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945143 HAMAP MF_01944 http://hamap.expasy.org/unirule/MF_01944 HOGENOM HOG000265962 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000265962&db=HOGENOM6 InParanoid P24205 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P24205 IntAct P24205 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P24205* IntEnz 2.3.1.243 {ECO:0000255|HAMAP-Rule:MF_01944, ECO:0000269|PubMed:9099672, ECO:0000305|PubMed:10092655} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.243 {ECO:0000255|HAMAP-Rule:MF_01944, ECO:0000269|PubMed:9099672, ECO:0000305|PubMed:10092655} InterPro IPR004960 http://www.ebi.ac.uk/interpro/entry/IPR004960 InterPro IPR011921 http://www.ebi.ac.uk/interpro/entry/IPR011921 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Gene ecj:JW1844 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1844 KEGG_Gene eco:b1855 http://www.genome.jp/dbget-bin/www_bget?eco:b1855 KEGG_Orthology KO:K02560 http://www.genome.jp/dbget-bin/www_bget?KO:K02560 KEGG_Pathway ko00540 http://www.genome.jp/kegg-bin/show_pathway?ko00540 KEGG_Reaction rn:R05075 http://www.genome.jp/dbget-bin/www_bget?rn:R05075 MINT MINT-1309336 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1309336 OMA QYVWILQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QYVWILQ PSORT swissprot:LPXM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LPXM_ECOLI PSORT-B swissprot:LPXM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LPXM_ECOLI PSORT2 swissprot:LPXM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LPXM_ECOLI Pfam PF03279 http://pfam.xfam.org/family/PF03279 Phobius swissprot:LPXM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LPXM_ECOLI PhylomeDB P24205 http://phylomedb.org/?seqid=P24205 ProteinModelPortal P24205 http://www.proteinmodelportal.org/query/uniprot/P24205 PubMed 10092655 http://www.ncbi.nlm.nih.gov/pubmed/10092655 PubMed 1356966 http://www.ncbi.nlm.nih.gov/pubmed/1356966 PubMed 16467300 http://www.ncbi.nlm.nih.gov/pubmed/16467300 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1732206 http://www.ncbi.nlm.nih.gov/pubmed/1732206 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9099672 http://www.ncbi.nlm.nih.gov/pubmed/9099672 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416369 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416369 RefSeq WP_000448381 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000448381 SMR P24205 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P24205 STRING 511145.b1855 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1855&targetmode=cogs STRING COG1560 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1560&targetmode=cogs TIGRFAMs TIGR02208 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02208 UniProtKB LPXM_ECOLI http://www.uniprot.org/uniprot/LPXM_ECOLI UniProtKB-AC P24205 http://www.uniprot.org/uniprot/P24205 charge swissprot:LPXM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LPXM_ECOLI eggNOG COG1560 http://eggnogapi.embl.de/nog_data/html/tree/COG1560 eggNOG ENOG4105NWR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105NWR epestfind swissprot:LPXM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LPXM_ECOLI garnier swissprot:LPXM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LPXM_ECOLI helixturnhelix swissprot:LPXM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LPXM_ECOLI hmoment swissprot:LPXM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LPXM_ECOLI iep swissprot:LPXM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LPXM_ECOLI inforesidue swissprot:LPXM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LPXM_ECOLI octanol swissprot:LPXM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LPXM_ECOLI pepcoil swissprot:LPXM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LPXM_ECOLI pepdigest swissprot:LPXM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LPXM_ECOLI pepinfo swissprot:LPXM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LPXM_ECOLI pepnet swissprot:LPXM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LPXM_ECOLI pepstats swissprot:LPXM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LPXM_ECOLI pepwheel swissprot:LPXM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LPXM_ECOLI pepwindow swissprot:LPXM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LPXM_ECOLI sigcleave swissprot:LPXM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LPXM_ECOLI ## Database ID URL or Descriptions # BioGrid 4260712 218 # EcoGene EG14302 hokE # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0006950 response to stress # InterPro IPR000021 Hok/gef_toxin # InterPro IPR018084 Hok/gef_toxin_CS # Organism HOKE_ECOLI Escherichia coli (strain K12) # PATRIC 32116332 VBIEscCol129921_0606 # PRINTS PR00281 HOKGEFTOXIC # PROSITE PS00556 HOK_GEF # Pfam PF01848 HOK_GEF # ProDom PD005979 Hok/gef_toxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HOKE_ECOLI Protein HokE # RefSeq WP_000956455 NZ_LN832404.1 # RefSeq YP_025295 NC_000913.3 # SEQUENCE CAUTION Sequence=AAB40780.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the hok/gef family. {ECO 0000305}. # SUBCELLULAR LOCATION HOKE_ECOLI Membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. # eggNOG ENOG4107635 Bacteria # eggNOG ENOG410Z5SJ LUCA BLAST swissprot:HOKE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HOKE_ECOLI BioCyc ECOL316407:JW5084-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5084-MONOMER BioCyc EcoCyc:MONOMER0-1581 http://biocyc.org/getid?id=EcoCyc:MONOMER0-1581 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1999.01431.x http://dx.doi.org/10.1046/j.1365-2958.1999.01431.x DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB4049 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4049 EcoGene EG14302 http://www.ecogene.org/geneInfo.php?eg_id=EG14302 EnsemblBacteria AAT48125 http://www.ensemblgenomes.org/id/AAT48125 EnsemblBacteria AAT48125 http://www.ensemblgenomes.org/id/AAT48125 EnsemblBacteria BAA35222 http://www.ensemblgenomes.org/id/BAA35222 EnsemblBacteria BAA35222 http://www.ensemblgenomes.org/id/BAA35222 EnsemblBacteria BAA35222 http://www.ensemblgenomes.org/id/BAA35222 EnsemblBacteria b4415 http://www.ensemblgenomes.org/id/b4415 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 2847715 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2847715 HOGENOM HOG000041219 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000041219&db=HOGENOM6 InterPro IPR000021 http://www.ebi.ac.uk/interpro/entry/IPR000021 InterPro IPR018084 http://www.ebi.ac.uk/interpro/entry/IPR018084 KEGG_Gene ecj:JW5084 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5084 KEGG_Gene eco:b4415 http://www.genome.jp/dbget-bin/www_bget?eco:b4415 OMA TKERSME http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TKERSME PRINTS PR00281 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00281 PROSITE PS00556 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00556 PSORT swissprot:HOKE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HOKE_ECOLI PSORT-B swissprot:HOKE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HOKE_ECOLI PSORT2 swissprot:HOKE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HOKE_ECOLI Pfam PF01848 http://pfam.xfam.org/family/PF01848 Phobius swissprot:HOKE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HOKE_ECOLI ProteinModelPortal P77091 http://www.proteinmodelportal.org/query/uniprot/P77091 PubMed 10361310 http://www.ncbi.nlm.nih.gov/pubmed/10361310 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000956455 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000956455 RefSeq YP_025295 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_025295 STRING 511145.b4415 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4415&targetmode=cogs UniProtKB HOKE_ECOLI http://www.uniprot.org/uniprot/HOKE_ECOLI UniProtKB-AC P77091 http://www.uniprot.org/uniprot/P77091 charge swissprot:HOKE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HOKE_ECOLI eggNOG ENOG4107635 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107635 eggNOG ENOG410Z5SJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Z5SJ epestfind swissprot:HOKE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HOKE_ECOLI garnier swissprot:HOKE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HOKE_ECOLI helixturnhelix swissprot:HOKE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HOKE_ECOLI hmoment swissprot:HOKE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HOKE_ECOLI iep swissprot:HOKE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HOKE_ECOLI inforesidue swissprot:HOKE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HOKE_ECOLI octanol swissprot:HOKE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HOKE_ECOLI pepcoil swissprot:HOKE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HOKE_ECOLI pepdigest swissprot:HOKE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HOKE_ECOLI pepinfo swissprot:HOKE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HOKE_ECOLI pepnet swissprot:HOKE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HOKE_ECOLI pepstats swissprot:HOKE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HOKE_ECOLI pepwheel swissprot:HOKE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HOKE_ECOLI pepwindow swissprot:HOKE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HOKE_ECOLI sigcleave swissprot:HOKE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HOKE_ECOLI ## Database ID URL or Descriptions # BioGrid 4261901 5 # DOMAIN YFIP_ECOLI Contains 1 DXTW motif. # EcoGene EG14223 yfiP # IntAct Q47319 2 # InterPro IPR005636 DTW # Organism YFIP_ECOLI Escherichia coli (strain K12) # PATRIC 32120567 VBIEscCol129921_2686 # PIR F65036 F65036 # Pfam PF03942 DTW # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFIP_ECOLI DTW domain-containing protein YfiP # RefSeq NP_417078 NC_000913.3 # RefSeq WP_001300438 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA10924.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the DTW family. {ECO 0000305}. # SMART SM01144 DTW # eggNOG COG3148 LUCA # eggNOG ENOG4106IUH Bacteria BLAST swissprot:YFIP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFIP_ECOLI BioCyc ECOL316407:JW5409-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5409-MONOMER BioCyc EcoCyc:G7349-MONOMER http://biocyc.org/getid?id=EcoCyc:G7349-MONOMER COG COG3148 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3148 DIP DIP-12067N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12067N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D64044 http://www.ebi.ac.uk/ena/data/view/D64044 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3975 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3975 EcoGene EG14223 http://www.ecogene.org/geneInfo.php?eg_id=EG14223 EnsemblBacteria AAC75636 http://www.ensemblgenomes.org/id/AAC75636 EnsemblBacteria AAC75636 http://www.ensemblgenomes.org/id/AAC75636 EnsemblBacteria BAE76753 http://www.ensemblgenomes.org/id/BAE76753 EnsemblBacteria BAE76753 http://www.ensemblgenomes.org/id/BAE76753 EnsemblBacteria BAE76753 http://www.ensemblgenomes.org/id/BAE76753 EnsemblBacteria b2583 http://www.ensemblgenomes.org/id/b2583 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947057 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947057 HOGENOM HOG000278320 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278320&db=HOGENOM6 InParanoid Q47319 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q47319 IntAct Q47319 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q47319* InterPro IPR005636 http://www.ebi.ac.uk/interpro/entry/IPR005636 KEGG_Gene ecj:JW5409 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5409 KEGG_Gene eco:b2583 http://www.genome.jp/dbget-bin/www_bget?eco:b2583 KEGG_Orthology KO:K05812 http://www.genome.jp/dbget-bin/www_bget?KO:K05812 MINT MINT-1246472 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1246472 OMA PSNTGWL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PSNTGWL PSORT swissprot:YFIP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFIP_ECOLI PSORT-B swissprot:YFIP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFIP_ECOLI PSORT2 swissprot:YFIP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFIP_ECOLI Pfam PF03942 http://pfam.xfam.org/family/PF03942 Phobius swissprot:YFIP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFIP_ECOLI PhylomeDB Q47319 http://phylomedb.org/?seqid=Q47319 ProteinModelPortal Q47319 http://www.proteinmodelportal.org/query/uniprot/Q47319 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417078 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417078 RefSeq WP_001300438 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300438 SMART SM01144 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01144 SMR Q47319 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q47319 STRING 511145.b2583 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2583&targetmode=cogs STRING COG3148 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3148&targetmode=cogs UniProtKB YFIP_ECOLI http://www.uniprot.org/uniprot/YFIP_ECOLI UniProtKB-AC Q47319 http://www.uniprot.org/uniprot/Q47319 charge swissprot:YFIP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFIP_ECOLI eggNOG COG3148 http://eggnogapi.embl.de/nog_data/html/tree/COG3148 eggNOG ENOG4106IUH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106IUH epestfind swissprot:YFIP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFIP_ECOLI garnier swissprot:YFIP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFIP_ECOLI helixturnhelix swissprot:YFIP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFIP_ECOLI hmoment swissprot:YFIP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFIP_ECOLI iep swissprot:YFIP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFIP_ECOLI inforesidue swissprot:YFIP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFIP_ECOLI octanol swissprot:YFIP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFIP_ECOLI pepcoil swissprot:YFIP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFIP_ECOLI pepdigest swissprot:YFIP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFIP_ECOLI pepinfo swissprot:YFIP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFIP_ECOLI pepnet swissprot:YFIP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFIP_ECOLI pepstats swissprot:YFIP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFIP_ECOLI pepwheel swissprot:YFIP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFIP_ECOLI pepwindow swissprot:YFIP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFIP_ECOLI sigcleave swissprot:YFIP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFIP_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES YQJG_ECOLI Kinetic parameters KM=840 uM for glutathione {ECO 0000269|PubMed 22686328, ECO 0000269|PubMed 22955277}; KM=70 uM for GS-methyl-p-hydroquinone {ECO 0000269|PubMed 22686328, ECO 0000269|PubMed 22955277}; KM=390 uM for GS-p-hydroquinone {ECO 0000269|PubMed 22686328, ECO 0000269|PubMed 22955277}; KM=35 uM for GS-hydroxy-p-hydroquinone {ECO 0000269|PubMed 22686328, ECO 0000269|PubMed 22955277}; KM=4 uM for GS-menadiol {ECO 0000269|PubMed 22686328, ECO 0000269|PubMed 22955277}; KM=341 uM for GS-p-hydroquinone {ECO 0000269|PubMed 22686328, ECO 0000269|PubMed 22955277}; Vmax=10.8 umol/min/mg enzyme for the reduction of glutathionyl- para-hydroquinone {ECO 0000269|PubMed 22686328, ECO 0000269|PubMed 22955277}; Note=kcat is 15, 14, 7.2 and 4.9 sec(-1) for the reduction of GS-MHQ, GS-HQ, GS-HHQ and GS-menadiol, respectively. {ECO 0000269|PubMed 22686328}; # BioGrid 4260937 20 # CATALYTIC ACTIVITY YQJG_ECOLI A glutathionyl-hydroquinone + glutathione = a hydroquinone + glutathione disulfide. {ECO 0000269|PubMed 20388120, ECO 0000269|PubMed 22686328, ECO 0000269|PubMed 22955277}. # EcoGene EG12746 yqjG # FUNCTION YQJG_ECOLI Catalyzes glutathione (GSH)-dependent reduction of glutathionyl-hydroquinones (GS-HQs) to the corresponding hydroquinones. Can use a variety of GS-HQs as substrates, such as GS-p-hydroquinone (GS-HQ), GS-hydroxy-p-hydroquinone (GS-HHQ), GS- methyl-p-hydroquinone (GS-MHQ), GS-menadiol, and GS-trichloro-p- hydroquinone (GS-TriCH). Also displays GSH-dependent disulfide- bond reduction activity toward HED (2-hydroxyethyl disulfide), and is able to catalyze DMA (dimethylarsinate) reduction. Exhibits no GSH transferase activity with 1-chloro-2,4-dinitrobenzene (CDNB). {ECO 0000269|PubMed 20388120, ECO 0000269|PubMed 22686328, ECO 0000269|PubMed 22955277}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0004364 glutathione transferase activity; IBA:GO_Central. # GO_function GO:0016491 oxidoreductase activity; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups # Gene3D 1.20.1050.10 -; 1. # Gene3D 3.40.30.10 -; 1. # IntAct P42620 13 # InterPro IPR004045 Glutathione_S-Trfase_N # InterPro IPR010987 Glutathione-S-Trfase_C-like # InterPro IPR012336 Thioredoxin-like_fold # InterPro IPR016639 GST # MISCELLANEOUS YQJG_ECOLI The reaction mechanism of reduction of GS-HQs is believed to involve a redox-active Cys that attacks the sulfhydryl of GS-hydroquinone, forming protein-glutathione mixed disulfide bond and releasing the hydroquinone. A GSH comes in to regenerate the protein and release GS-SG to complete the reaction. # Organism YQJG_ECOLI Escherichia coli (strain K12) # PANTHER PTHR32419 PTHR32419 # PATRIC 32121624 VBIEscCol129921_3198 # PDB 3R3E X-ray; 2.20 A; A/B=1-328 # PDB 4G0I X-ray; 2.05 A; A/B=1-328 # PDB 4G0K X-ray; 2.56 A; A/B=1-328 # PDB 4G0L X-ray; 2.62 A; A/B=1-328 # PIR C65099 C65099 # PIRSF PIRSF015753 GST # PROSITE PS50405 GST_CTER # Pfam PF13409 GST_N_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQJG_ECOLI Glutathionyl-hydroquinone reductase YqjG # RefSeq NP_417573 NC_000913.3 # RefSeq WP_000531213 NZ_LN832404.1 # SIMILARITY Belongs to the GST superfamily. Xi-class GSH transferase family. {ECO 0000305}. # SIMILARITY Contains 1 GST C-terminal domain. {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 22955277, ECO:0000269|Ref.5}. # SUPFAM SSF47616 SSF47616 # SUPFAM SSF52833 SSF52833; 2 # eggNOG COG0435 LUCA # eggNOG ENOG4105CHF Bacteria BLAST swissprot:YQJG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQJG_ECOLI BioCyc ECOL316407:JW3073-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3073-MONOMER BioCyc EcoCyc:G7616-MONOMER http://biocyc.org/getid?id=EcoCyc:G7616-MONOMER BioCyc MetaCyc:G7616-MONOMER http://biocyc.org/getid?id=MetaCyc:G7616-MONOMER COG COG0435 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0435 DIP DIP-12888N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12888N DOI 10.1021/bi300477z http://dx.doi.org/10.1021/bi300477z DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/BJ20091863 http://dx.doi.org/10.1042/BJ20091863 DOI 10.1074/jbc.M112.395541 http://dx.doi.org/10.1074/jbc.M112.395541 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.8.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.8.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 1.8.-.- http://enzyme.expasy.org/EC/1.8.-.- EchoBASE EB2602 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2602 EcoGene EG12746 http://www.ecogene.org/geneInfo.php?eg_id=EG12746 EnsemblBacteria AAC76137 http://www.ensemblgenomes.org/id/AAC76137 EnsemblBacteria AAC76137 http://www.ensemblgenomes.org/id/AAC76137 EnsemblBacteria BAE77152 http://www.ensemblgenomes.org/id/BAE77152 EnsemblBacteria BAE77152 http://www.ensemblgenomes.org/id/BAE77152 EnsemblBacteria BAE77152 http://www.ensemblgenomes.org/id/BAE77152 EnsemblBacteria b3102 http://www.ensemblgenomes.org/id/b3102 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004364 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004364 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016765 Gene3D 1.20.1050.10 http://www.cathdb.info/version/latest/superfamily/1.20.1050.10 Gene3D 3.40.30.10 http://www.cathdb.info/version/latest/superfamily/3.40.30.10 GeneID 947615 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947615 HOGENOM HOG000245143 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000245143&db=HOGENOM6 InParanoid P42620 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P42620 IntAct P42620 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P42620* IntEnz 1.8 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.8 InterPro IPR004045 http://www.ebi.ac.uk/interpro/entry/IPR004045 InterPro IPR010987 http://www.ebi.ac.uk/interpro/entry/IPR010987 InterPro IPR012336 http://www.ebi.ac.uk/interpro/entry/IPR012336 InterPro IPR016639 http://www.ebi.ac.uk/interpro/entry/IPR016639 KEGG_Gene ecj:JW3073 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3073 KEGG_Gene eco:b3102 http://www.genome.jp/dbget-bin/www_bget?eco:b3102 KEGG_Orthology KO:K07393 http://www.genome.jp/dbget-bin/www_bget?KO:K07393 OMA SQFRNWV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SQFRNWV PANTHER PTHR32419 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32419 PDB 3R3E http://www.ebi.ac.uk/pdbe-srv/view/entry/3R3E PDB 4G0I http://www.ebi.ac.uk/pdbe-srv/view/entry/4G0I PDB 4G0K http://www.ebi.ac.uk/pdbe-srv/view/entry/4G0K PDB 4G0L http://www.ebi.ac.uk/pdbe-srv/view/entry/4G0L PDBsum 3R3E http://www.ebi.ac.uk/pdbsum/3R3E PDBsum 4G0I http://www.ebi.ac.uk/pdbsum/4G0I PDBsum 4G0K http://www.ebi.ac.uk/pdbsum/4G0K PDBsum 4G0L http://www.ebi.ac.uk/pdbsum/4G0L PROSITE PS50405 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50405 PSORT swissprot:YQJG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQJG_ECOLI PSORT-B swissprot:YQJG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQJG_ECOLI PSORT2 swissprot:YQJG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQJG_ECOLI Pfam PF13409 http://pfam.xfam.org/family/PF13409 Phobius swissprot:YQJG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQJG_ECOLI PhylomeDB P42620 http://phylomedb.org/?seqid=P42620 ProteinModelPortal P42620 http://www.proteinmodelportal.org/query/uniprot/P42620 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20388120 http://www.ncbi.nlm.nih.gov/pubmed/20388120 PubMed 22686328 http://www.ncbi.nlm.nih.gov/pubmed/22686328 PubMed 22955277 http://www.ncbi.nlm.nih.gov/pubmed/22955277 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417573 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417573 RefSeq WP_000531213 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000531213 SMR P42620 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P42620 STRING 511145.b3102 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3102&targetmode=cogs STRING COG0435 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0435&targetmode=cogs SUPFAM SSF47616 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47616 SUPFAM SSF52833 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52833 UniProtKB YQJG_ECOLI http://www.uniprot.org/uniprot/YQJG_ECOLI UniProtKB-AC P42620 http://www.uniprot.org/uniprot/P42620 charge swissprot:YQJG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQJG_ECOLI eggNOG COG0435 http://eggnogapi.embl.de/nog_data/html/tree/COG0435 eggNOG ENOG4105CHF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CHF epestfind swissprot:YQJG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQJG_ECOLI garnier swissprot:YQJG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQJG_ECOLI helixturnhelix swissprot:YQJG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQJG_ECOLI hmoment swissprot:YQJG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQJG_ECOLI iep swissprot:YQJG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQJG_ECOLI inforesidue swissprot:YQJG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQJG_ECOLI octanol swissprot:YQJG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQJG_ECOLI pepcoil swissprot:YQJG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQJG_ECOLI pepdigest swissprot:YQJG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQJG_ECOLI pepinfo swissprot:YQJG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQJG_ECOLI pepnet swissprot:YQJG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQJG_ECOLI pepstats swissprot:YQJG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQJG_ECOLI pepwheel swissprot:YQJG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQJG_ECOLI pepwindow swissprot:YQJG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQJG_ECOLI sigcleave swissprot:YQJG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQJG_ECOLI ## Database ID URL or Descriptions # AltName N6-L-threonylcarbamoyladenine synthase {ECO:0000255|HAMAP-Rule MF_01445} # AltName t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD {ECO:0000255|HAMAP-Rule MF_01445} # AltName tRNA threonylcarbamoyladenosine biosynthesis protein TsaD {ECO:0000255|HAMAP-Rule MF_01445} # BRENDA 2.6.99 2026 # BioGrid 4261402 64 # CATALYTIC ACTIVITY TSAD_ECOLI L-threonylcarbamoyladenylate + adenine(37) in tRNA = AMP + N(6)-L-threonylcarbamoyladenine(37) in tRNA. {ECO 0000255|HAMAP-Rule MF_01445, ECO 0000269|PubMed 22378793}. # CAUTION TSAD_ECOLI Was proposed to be a ligase for bicarbonate and threonine (PubMed 21285948) in the first step, TsaD would catalyze transfer of a gamma-phosphate group from ATP to bicarbonate, yielding carboxyphosphate and ADP; carboxyphosphate would then react with the threonine amine, producing N-carbamoylthreonine and phosphate. However, the protein ortholog in B.subtilis was shown to be involved in another step of t(6)A37 biosynthesis, i.e. the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB (PubMed 23072323). The protein ortholog in yeast (QRI7) was also shown to catalyze this step, and does not require the presence of additional proteins (PubMed 23620299). {ECO 0000305|PubMed 21285948}. # CAUTION The well-known t(6)A modification appears to be a hydrolyzed artifact of natural cyclic t(6)A (ct(6)A) that occurs during the preparation and handling of tRNA in E.coli and many other species (PubMed:23242255). In these species, the t(6)A modification is processed further by dehydration into ct(6)A, a reaction catalyzed by TcdA. {ECO 0000305}. # COFACTOR TSAD_ECOLI Name=Fe(2+); Xref=ChEBI CHEBI 29033; Evidence={ECO 0000255|HAMAP-Rule MF_01445}; Note=Binds 1 Fe(2+) ion per subunit. {ECO 0000255|HAMAP- Rule MF_01445}; # DISRUPTION PHENOTYPE TSAD_ECOLI Appears essential for growth, since no null mutants can be obtained. Conditional depletion of this gene prevents t(6)A37 modification, and leads to pleiotropic phenotypes including increased or reduced cell size, unusual distribution of DNA around the cell periphery, nucleoid loss, and membrane/cell envelope defects. These phenotypes could be indirect effects of severe translation defects. The TsaD depletion phenotype is suppressed by overexpressing the response regulator RstA. {ECO 0000269|PubMed 19376873, ECO 0000269|PubMed 19578062, ECO 0000269|PubMed 21183954, ECO 0000269|PubMed 9743119}. # EcoGene EG11171 tsaD # FUNCTION TSAD_ECOLI Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction. May also be involved in the metabolism of glycated proteins, but does not show sialoglycoprotease activity against glycophorin A. {ECO 0000269|PubMed 20824107, ECO 0000269|PubMed 21183954, ECO 0000269|PubMed 22378793}. # GO_component GO:0000408 EKC/KEOPS complex; IBA:GO_Central. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0001948 glycoprotein binding; IDA:EcoCyc. # GO_function GO:0004222 metalloendopeptidase activity; IEA:InterPro. # GO_function GO:0005506 iron ion binding; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0061711 N(6)-L-threonylcarbamoyladenine synthase; IEA:UniProtKB-EC. # GO_process GO:0002949 tRNA threonylcarbamoyladenosine modification; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # HAMAP MF_01445 TsaD # INTERACTION TSAD_ECOLI P76256 tsaB; NbExp=6; IntAct=EBI-561994, EBI-560669; # IntAct P05852 14 # InterPro IPR000905 Gcp-like_dom # InterPro IPR017860 Peptidase_M22_CS # InterPro IPR017861 KAE1/TsaD # InterPro IPR022450 TsaD # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # KEGG_Brite ko03016 Transfer RNA biogenesis # MISCELLANEOUS TsaBCDE are necessary and sufficient for tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification in vitro in E.coli. {ECO:0000305|PubMed 22378793}. # Organism TSAD_ECOLI Escherichia coli (strain K12) # PATRIC 32121542 VBIEscCol129921_3158 # PDB 4WQ4 X-ray; 2.33 A; A/B=1-337 # PDB 4WQ5 X-ray; 2.33 A; A/B=1-337 # PDB 4YDU X-ray; 2.33 A; A/B=1-337 # PIR F65094 QQECR6 # PRINTS PR00789 OSIALOPTASE # PROSITE PS01016 GLYCOPROTEASE # PTM TSAD_ECOLI Can be proteolytically processed in vitro by TsaB. {ECO 0000269|PubMed 19376873}. # Pfam PF00814 Peptidase_M22 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName tRNA N6-adenosine threonylcarbamoyltransferase {ECO:0000255|HAMAP-Rule MF_01445} # RefSeq NP_417536 NC_000913.3 # RefSeq WP_001264352 NZ_LN832404.1 # SIMILARITY Belongs to the KAE1 / TsaD family. {ECO:0000255|HAMAP- Rule MF_01445}. # SUBCELLULAR LOCATION TSAD_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_01445, ECO 0000269|PubMed 19376873}. # SUBUNIT TSAD_ECOLI Homodimer. Interacts with TsaB; may form a heterodimer with TsaB. Also interacts with TsaC. {ECO 0000269|PubMed 19376873, ECO 0000269|PubMed 20701780, ECO 0000269|PubMed 21285948, ECO 0000269|PubMed 22378793}. # TIGRFAMs TIGR00329 gcp_kae1 # TIGRFAMs TIGR03723 T6A_TsaD_YgjD # eggNOG COG0533 LUCA # eggNOG ENOG4105CPM Bacteria BLAST swissprot:TSAD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TSAD_ECOLI BioCyc ECOL316407:JW3036-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3036-MONOMER BioCyc EcoCyc:EG11171-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11171-MONOMER BioCyc MetaCyc:EG11171-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11171-MONOMER COG COG0533 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0533 DIP DIP-9749N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9749N DOI 10.1016/0378-1119(87)90303-9 http://dx.doi.org/10.1016/0378-1119(87)90303-9 DOI 10.1038/emboj.2010.343 http://dx.doi.org/10.1038/emboj.2010.343 DOI 10.1038/emboj.2010.363 http://dx.doi.org/10.1038/emboj.2010.363 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nbt0998-851 http://dx.doi.org/10.1038/nbt0998-851 DOI 10.1074/jbc.M112.344028 http://dx.doi.org/10.1074/jbc.M112.344028 DOI 10.1093/nar/gkp557 http://dx.doi.org/10.1093/nar/gkp557 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00136-09 http://dx.doi.org/10.1128/JB.00136-09 DOI 10.1128/mBio.00195-10 http://dx.doi.org/10.1128/mBio.00195-10 DOI 10.1186/1471-2164-11-470 http://dx.doi.org/10.1186/1471-2164-11-470 EC_number EC:2.3.1.234 {ECO:0000255|HAMAP-Rule:MF_01445, ECO:0000269|PubMed:22378793} http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.234 {ECO:0000255|HAMAP-Rule:MF_01445, ECO:0000269|PubMed:22378793} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M16194 http://www.ebi.ac.uk/ena/data/view/M16194 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28379 http://www.ebi.ac.uk/ena/data/view/U28379 ENZYME 2.3.1.234 {ECO:0000255|HAMAP-Rule:MF_01445, ECO:0000269|PubMed:22378793} http://enzyme.expasy.org/EC/2.3.1.234 {ECO:0000255|HAMAP-Rule:MF_01445, ECO:0000269|PubMed:22378793} EchoBASE EB1158 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1158 EcoGene EG11171 http://www.ecogene.org/geneInfo.php?eg_id=EG11171 EnsemblBacteria AAC76100 http://www.ensemblgenomes.org/id/AAC76100 EnsemblBacteria AAC76100 http://www.ensemblgenomes.org/id/AAC76100 EnsemblBacteria BAE77115 http://www.ensemblgenomes.org/id/BAE77115 EnsemblBacteria BAE77115 http://www.ensemblgenomes.org/id/BAE77115 EnsemblBacteria BAE77115 http://www.ensemblgenomes.org/id/BAE77115 EnsemblBacteria b3064 http://www.ensemblgenomes.org/id/b3064 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0000408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000408 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0001948 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001948 GO_function GO:0004222 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004222 GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0061711 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061711 GO_process GO:0002949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002949 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GeneID 947578 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947578 HAMAP MF_01445 http://hamap.expasy.org/unirule/MF_01445 HOGENOM HOG000109568 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000109568&db=HOGENOM6 InParanoid P05852 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P05852 IntAct P05852 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P05852* IntEnz 2.3.1.234 {ECO:0000255|HAMAP-Rule:MF_01445, ECO:0000269|PubMed:22378793} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.234 {ECO:0000255|HAMAP-Rule:MF_01445, ECO:0000269|PubMed:22378793} InterPro IPR000905 http://www.ebi.ac.uk/interpro/entry/IPR000905 InterPro IPR017860 http://www.ebi.ac.uk/interpro/entry/IPR017860 InterPro IPR017861 http://www.ebi.ac.uk/interpro/entry/IPR017861 InterPro IPR022450 http://www.ebi.ac.uk/interpro/entry/IPR022450 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW3036 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3036 KEGG_Gene eco:b3064 http://www.genome.jp/dbget-bin/www_bget?eco:b3064 KEGG_Orthology KO:K01409 http://www.genome.jp/dbget-bin/www_bget?KO:K01409 OMA RDHVKRM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RDHVKRM PDB 4WQ4 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WQ4 PDB 4WQ5 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WQ5 PDB 4YDU http://www.ebi.ac.uk/pdbe-srv/view/entry/4YDU PDBsum 4WQ4 http://www.ebi.ac.uk/pdbsum/4WQ4 PDBsum 4WQ5 http://www.ebi.ac.uk/pdbsum/4WQ5 PDBsum 4YDU http://www.ebi.ac.uk/pdbsum/4YDU PRINTS PR00789 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00789 PROSITE PS01016 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01016 PSORT swissprot:TSAD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TSAD_ECOLI PSORT-B swissprot:TSAD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TSAD_ECOLI PSORT2 swissprot:TSAD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TSAD_ECOLI Pfam PF00814 http://pfam.xfam.org/family/PF00814 Phobius swissprot:TSAD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TSAD_ECOLI PhylomeDB P05852 http://phylomedb.org/?seqid=P05852 ProteinModelPortal P05852 http://www.proteinmodelportal.org/query/uniprot/P05852 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19376873 http://www.ncbi.nlm.nih.gov/pubmed/19376873 PubMed 19578062 http://www.ncbi.nlm.nih.gov/pubmed/19578062 PubMed 20701780 http://www.ncbi.nlm.nih.gov/pubmed/20701780 PubMed 20824107 http://www.ncbi.nlm.nih.gov/pubmed/20824107 PubMed 21183954 http://www.ncbi.nlm.nih.gov/pubmed/21183954 PubMed 21285948 http://www.ncbi.nlm.nih.gov/pubmed/21285948 PubMed 22378793 http://www.ncbi.nlm.nih.gov/pubmed/22378793 PubMed 3297921 http://www.ncbi.nlm.nih.gov/pubmed/3297921 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9743119 http://www.ncbi.nlm.nih.gov/pubmed/9743119 RefSeq NP_417536 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417536 RefSeq WP_001264352 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001264352 SMR P05852 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P05852 STRING 511145.b3064 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3064&targetmode=cogs STRING COG0533 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0533&targetmode=cogs TIGRFAMs TIGR00329 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00329 TIGRFAMs TIGR03723 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03723 UniProtKB TSAD_ECOLI http://www.uniprot.org/uniprot/TSAD_ECOLI UniProtKB-AC P05852 http://www.uniprot.org/uniprot/P05852 charge swissprot:TSAD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TSAD_ECOLI eggNOG COG0533 http://eggnogapi.embl.de/nog_data/html/tree/COG0533 eggNOG ENOG4105CPM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CPM epestfind swissprot:TSAD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TSAD_ECOLI garnier swissprot:TSAD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TSAD_ECOLI helixturnhelix swissprot:TSAD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TSAD_ECOLI hmoment swissprot:TSAD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TSAD_ECOLI iep swissprot:TSAD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TSAD_ECOLI inforesidue swissprot:TSAD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TSAD_ECOLI octanol swissprot:TSAD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TSAD_ECOLI pepcoil swissprot:TSAD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TSAD_ECOLI pepdigest swissprot:TSAD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TSAD_ECOLI pepinfo swissprot:TSAD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TSAD_ECOLI pepnet swissprot:TSAD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TSAD_ECOLI pepstats swissprot:TSAD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TSAD_ECOLI pepwheel swissprot:TSAD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TSAD_ECOLI pepwindow swissprot:TSAD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TSAD_ECOLI sigcleave swissprot:TSAD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TSAD_ECOLI ## Database ID URL or Descriptions # BioGrid 4262392 5 # EcoGene EG12657 ygiN # FUNCTION YGIN_ECOLI Can oxidize menadiol to menadione. {ECO 0000269|PubMed 15613473}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0016491 oxidoreductase activity; IDA:EcoCyc. # GO_process GO:0010447 response to acidic pH; IEP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0008150 biological_process # IntAct P0ADU2 2 # InterPro IPR007138 ABM_dom # InterPro IPR011008 Dimeric_a/b-barrel # Organism YGIN_ECOLI Escherichia coli (strain K12) # PATRIC 32121468 VBIEscCol129921_3121 # PDB 1R6Y X-ray; 2.20 A; A=1-104 # PDB 1TUV X-ray; 1.70 A; A=1-104 # PIR C65090 C65090 # PROSITE PS51725 ABM # Pfam PF03992 ABM # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGIN_ECOLI Probable quinol monooxygenase YgiN # RefSeq NP_417501 NC_000913.3 # RefSeq WP_000958598 NZ_LN832404.1 # SIMILARITY Contains 1 ABM domain. {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 15613473}. # SUPFAM SSF54909 SSF54909 # eggNOG COG1359 LUCA # eggNOG ENOG4105VRH Bacteria BLAST swissprot:YGIN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGIN_ECOLI BioCyc ECOL316407:JW2997-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2997-MONOMER BioCyc EcoCyc:EG12657-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12657-MONOMER BioCyc MetaCyc:EG12657-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12657-MONOMER DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1998.1726 http://dx.doi.org/10.1006/jmbi.1998.1726 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.92.19.8950 http://dx.doi.org/10.1073/pnas.92.19.8950 DOI 10.1074/jbc.M412637200 http://dx.doi.org/10.1074/jbc.M412637200 DOI 10.1111/j.1574-6968.1998.tb13343.x http://dx.doi.org/10.1111/j.1574-6968.1998.tb13343.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18656 http://www.ebi.ac.uk/ena/data/view/U18656 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- EchoBASE EB2525 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2525 EcoGene EG12657 http://www.ecogene.org/geneInfo.php?eg_id=EG12657 EnsemblBacteria AAC76065 http://www.ensemblgenomes.org/id/AAC76065 EnsemblBacteria AAC76065 http://www.ensemblgenomes.org/id/AAC76065 EnsemblBacteria BAE77085 http://www.ensemblgenomes.org/id/BAE77085 EnsemblBacteria BAE77085 http://www.ensemblgenomes.org/id/BAE77085 EnsemblBacteria BAE77085 http://www.ensemblgenomes.org/id/BAE77085 EnsemblBacteria b3029 http://www.ensemblgenomes.org/id/b3029 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_process GO:0010447 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010447 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 947506 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947506 HOGENOM HOG000145619 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000145619&db=HOGENOM6 InParanoid P0ADU2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADU2 IntAct P0ADU2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADU2* IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR007138 http://www.ebi.ac.uk/interpro/entry/IPR007138 InterPro IPR011008 http://www.ebi.ac.uk/interpro/entry/IPR011008 KEGG_Gene ecj:JW2997 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2997 KEGG_Gene eco:b3029 http://www.genome.jp/dbget-bin/www_bget?eco:b3029 OMA VLQEEGC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VLQEEGC PDB 1R6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/1R6Y PDB 1TUV http://www.ebi.ac.uk/pdbe-srv/view/entry/1TUV PDBsum 1R6Y http://www.ebi.ac.uk/pdbsum/1R6Y PDBsum 1TUV http://www.ebi.ac.uk/pdbsum/1TUV PROSITE PS51725 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51725 PSORT swissprot:YGIN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGIN_ECOLI PSORT-B swissprot:YGIN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGIN_ECOLI PSORT2 swissprot:YGIN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGIN_ECOLI Pfam PF03992 http://pfam.xfam.org/family/PF03992 Phobius swissprot:YGIN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGIN_ECOLI ProteinModelPortal P0ADU2 http://www.proteinmodelportal.org/query/uniprot/P0ADU2 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 15613473 http://www.ncbi.nlm.nih.gov/pubmed/15613473 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7568050 http://www.ncbi.nlm.nih.gov/pubmed/7568050 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 PubMed 9868784 http://www.ncbi.nlm.nih.gov/pubmed/9868784 RefSeq NP_417501 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417501 RefSeq WP_000958598 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000958598 SMR P0ADU2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADU2 STRING 511145.b3029 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3029&targetmode=cogs SUPFAM SSF54909 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54909 SWISS-2DPAGE P0ADU2 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0ADU2 UniProtKB YGIN_ECOLI http://www.uniprot.org/uniprot/YGIN_ECOLI UniProtKB-AC P0ADU2 http://www.uniprot.org/uniprot/P0ADU2 charge swissprot:YGIN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGIN_ECOLI eggNOG COG1359 http://eggnogapi.embl.de/nog_data/html/tree/COG1359 eggNOG ENOG4105VRH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VRH epestfind swissprot:YGIN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGIN_ECOLI garnier swissprot:YGIN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGIN_ECOLI helixturnhelix swissprot:YGIN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGIN_ECOLI hmoment swissprot:YGIN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGIN_ECOLI iep swissprot:YGIN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGIN_ECOLI inforesidue swissprot:YGIN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGIN_ECOLI octanol swissprot:YGIN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGIN_ECOLI pepcoil swissprot:YGIN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGIN_ECOLI pepdigest swissprot:YGIN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGIN_ECOLI pepinfo swissprot:YGIN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGIN_ECOLI pepnet swissprot:YGIN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGIN_ECOLI pepstats swissprot:YGIN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGIN_ECOLI pepwheel swissprot:YGIN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGIN_ECOLI pepwindow swissprot:YGIN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGIN_ECOLI sigcleave swissprot:YGIN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGIN_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES YEIR_ECOLI Kinetic parameters KM=220 uM for GTP (in the absence of metal ions) {ECO 0000269|PubMed 22511334}; KM=177 uM for GTP (in the presence of Ni(2+)) {ECO 0000269|PubMed 22511334}; KM=49 uM for GTP (in the presence of Zn(2+)) {ECO 0000269|PubMed 22511334}; Note=kcat is 0.19 min(-1). kcat is 0.33 min(-1) in the presence of Ni(2+). kcat is 0.32 min(-1) in the presence of Zn(2+). {ECO 0000269|PubMed 22511334}; # BioGrid 4260468 311 # DISRUPTION PHENOTYPE Deletion of the gene increases the sensitivity of E.coli to the metal chelator EDTA and sensitivity to cadmium. {ECO:0000269|PubMed 22511334}. # ENZYME REGULATION GTPase activity is enhanced by Zn(2+) binding. {ECO:0000269|PubMed 22511334}. # EcoGene EG12104 yeiR # FUNCTION YEIR_ECOLI Involved in metal homeostasis. Has GTPase activity. Binds several Zn(2+) ions in vitro. {ECO 0000269|PubMed 22511334}. # GO_function GO:0003924 GTPase activity; IDA:EcoCyc. # GO_function GO:0005525 GTP binding; IEA:UniProtKB-KW. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GOslim_function GO:0003924 GTPase activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.300 -; 1. # IntAct P33030 14 # InterPro IPR003495 CobW/HypB/UreG_dom # InterPro IPR011629 Cbl_biosynth_CobW-like_C # InterPro IPR027417 P-loop_NTPase # Organism YEIR_ECOLI Escherichia coli (strain K12) # PATRIC 32119701 VBIEscCol129921_2261 # PIR D64986 D64986 # Pfam PF02492 cobW # Pfam PF07683 CobW_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Zinc-binding GTPase YeiR {ECO 0000305} # RefSeq NP_416678 NC_000913.3 # RefSeq WP_000198828 NZ_LN832404.1 # SIMILARITY Belongs to the SIMIBI class G3E GTPase family. CobW subfamily. {ECO 0000305}. # SIMILARITY Contains 1 cobW C-terminal domain. {ECO 0000255}. # SMART SM00833 CobW_C # SUBUNIT Oligomerizes in the presence of Zn(2+). {ECO:0000269|PubMed 22511334}. # SUPFAM SSF52540 SSF52540 # eggNOG COG0523 LUCA # eggNOG ENOG4105CKI Bacteria BLAST swissprot:YEIR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEIR_ECOLI BioCyc ECOL316407:JW2161-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2161-MONOMER BioCyc EcoCyc:EG12104-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12104-MONOMER BioCyc MetaCyc:EG12104-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12104-MONOMER DIP DIP-11929N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11929N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1039/c2mt20012k http://dx.doi.org/10.1039/c2mt20012k DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.6.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.6.-.- http://enzyme.expasy.org/EC/3.6.-.- EchoBASE EB2028 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2028 EcoGene EG12104 http://www.ecogene.org/geneInfo.php?eg_id=EG12104 EnsemblBacteria AAC75234 http://www.ensemblgenomes.org/id/AAC75234 EnsemblBacteria AAC75234 http://www.ensemblgenomes.org/id/AAC75234 EnsemblBacteria BAA15982 http://www.ensemblgenomes.org/id/BAA15982 EnsemblBacteria BAA15982 http://www.ensemblgenomes.org/id/BAA15982 EnsemblBacteria BAA15982 http://www.ensemblgenomes.org/id/BAA15982 EnsemblBacteria b2173 http://www.ensemblgenomes.org/id/b2173 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GOslim_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 946701 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946701 HOGENOM HOG000294929 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000294929&db=HOGENOM6 InParanoid P33030 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33030 IntAct P33030 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33030* IntEnz 3.6 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6 InterPro IPR003495 http://www.ebi.ac.uk/interpro/entry/IPR003495 InterPro IPR011629 http://www.ebi.ac.uk/interpro/entry/IPR011629 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Gene ecj:JW2161 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2161 KEGG_Gene eco:b2173 http://www.genome.jp/dbget-bin/www_bget?eco:b2173 MINT MINT-1231253 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1231253 OMA CICCTAN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CICCTAN PSORT swissprot:YEIR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEIR_ECOLI PSORT-B swissprot:YEIR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEIR_ECOLI PSORT2 swissprot:YEIR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEIR_ECOLI Pfam PF02492 http://pfam.xfam.org/family/PF02492 Pfam PF07683 http://pfam.xfam.org/family/PF07683 Phobius swissprot:YEIR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEIR_ECOLI PhylomeDB P33030 http://phylomedb.org/?seqid=P33030 ProteinModelPortal P33030 http://www.proteinmodelportal.org/query/uniprot/P33030 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22511334 http://www.ncbi.nlm.nih.gov/pubmed/22511334 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416678 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416678 RefSeq WP_000198828 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000198828 SMART SM00833 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00833 STRING 511145.b2173 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2173&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB YEIR_ECOLI http://www.uniprot.org/uniprot/YEIR_ECOLI UniProtKB-AC P33030 http://www.uniprot.org/uniprot/P33030 charge swissprot:YEIR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEIR_ECOLI eggNOG COG0523 http://eggnogapi.embl.de/nog_data/html/tree/COG0523 eggNOG ENOG4105CKI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CKI epestfind swissprot:YEIR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEIR_ECOLI garnier swissprot:YEIR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEIR_ECOLI helixturnhelix swissprot:YEIR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEIR_ECOLI hmoment swissprot:YEIR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEIR_ECOLI iep swissprot:YEIR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEIR_ECOLI inforesidue swissprot:YEIR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEIR_ECOLI octanol swissprot:YEIR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEIR_ECOLI pepcoil swissprot:YEIR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEIR_ECOLI pepdigest swissprot:YEIR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEIR_ECOLI pepinfo swissprot:YEIR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEIR_ECOLI pepnet swissprot:YEIR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEIR_ECOLI pepstats swissprot:YEIR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEIR_ECOLI pepwheel swissprot:YEIR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEIR_ECOLI pepwindow swissprot:YEIR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEIR_ECOLI sigcleave swissprot:YEIR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEIR_ECOLI ## Database ID URL or Descriptions # CDD cd00353 Ribosomal_S15p_S13e # EcoGene EG10914 rpsO # FUNCTION RS15_ECOLI In the E.coli 70S ribosome it has been modeled (PubMed 12809609) to contact the 23S rRNA of the 50S subunit forming part of bridge B4. In the two 3.5 A resolved ribosome structures (PubMed 16272117) there are minor differences between side-chain conformations. {ECO 0000269|PubMed 12244297, ECO 0000269|PubMed 12809609, ECO 0000269|PubMed 16272117}. # FUNCTION RS15_ECOLI One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA (PubMed 12809609, PubMed 16272117). Binds to its own mRNA, stabilizing it 5-UTR and preventing its translation (PubMed 24339747). {ECO 0000269|PubMed 12809609, ECO 0000269|PubMed 16272117, ECO 0000269|PubMed 24339747}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0022627 cytosolic small ribosomal subunit; IDA:EcoliWiki. # GO_function GO:0003735 structural constituent of ribosome; IBA:GO_Central. # GO_function GO:0019843 rRNA binding; IDA:EcoliWiki. # GO_process GO:0006378 mRNA polyadenylation; IDA:EcoliWiki. # GO_process GO:0006412 translation; IBA:GO_Central. # GO_process GO:0006417 regulation of translation; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_function GO:0019843 rRNA binding # GOslim_process GO:0006397 mRNA processing # GOslim_process GO:0006412 translation # GOslim_process GO:0008150 biological_process # Gene3D 1.10.287.10 -; 1. # HAMAP MF_01343_B Ribosomal_S15_B # IntAct P0ADZ4 30 # InterPro IPR000589 Ribosomal_S15 # InterPro IPR005290 Ribosomal_S15_bac-type # InterPro IPR009068 S15_NS1_RNA-bd # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 M00179 Ribosome, archaea # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=10137.6; Method=MALDI; Range=2-89; Evidence={ECO:0000269|PubMed 10094780}; # Organism RS15_ECOLI Escherichia coli (strain K12) # PATRIC 32121748 VBIEscCol129921_3260 # PDB 1EG0 EM; 11.50 A; F=1-89 # PDB 2VAZ EM; 10.00 A; F=2-89 # PDB 2YKR EM; 9.80 A; O=2-89 # PDB 3J9Y EM; 3.90 A; o=1-89 # PDB 3J9Z EM; 3.60 A; SO=2-89 # PDB 3JA1 EM; 3.60 A; SO=2-89 # PDB 3JBU EM; 3.64 A; O=1-89 # PDB 3JBV EM; 3.32 A; O=1-89 # PDB 3JCD EM; 3.70 A; o=1-89 # PDB 3JCE EM; 3.20 A; o=1-89 # PDB 3JCJ EM; 3.70 A; u=1-89 # PDB 3JCN EM; 4.60 A; p=1-89 # PDB 4A2I EM; 16.50 A; O=2-89 # PDB 4ADV EM; 13.50 A; O=1-89 # PDB 4U1U X-ray; 2.95 A; AO/CO=2-89 # PDB 4U1V X-ray; 3.00 A; AO/CO=2-89 # PDB 4U20 X-ray; 2.90 A; AO/CO=2-89 # PDB 4U24 X-ray; 2.90 A; AO/CO=2-89 # PDB 4U25 X-ray; 2.90 A; AO/CO=2-89 # PDB 4U26 X-ray; 2.80 A; AO/CO=2-89 # PDB 4U27 X-ray; 2.80 A; AO/CO=2-89 # PDB 4V47 EM; 12.30 A; BO=2-89 # PDB 4V48 EM; 11.50 A; BO=2-89 # PDB 4V4H X-ray; 3.46 A; AO/CO=1-89 # PDB 4V4Q X-ray; 3.46 A; AO/CO=1-89 # PDB 4V4V EM; 15.00 A; AO=3-88 # PDB 4V4W EM; 15.00 A; AO=3-88 # PDB 4V50 X-ray; 3.22 A; AO/CO=2-89 # PDB 4V52 X-ray; 3.21 A; AO/CO=1-89 # PDB 4V53 X-ray; 3.54 A; AO/CO=1-89 # PDB 4V54 X-ray; 3.30 A; AO/CO=1-89 # PDB 4V55 X-ray; 4.00 A; AO/CO=1-89 # PDB 4V56 X-ray; 3.93 A; AO/CO=1-89 # PDB 4V57 X-ray; 3.50 A; AO/CO=1-89 # PDB 4V5B X-ray; 3.74 A; BO/DO=1-89 # PDB 4V5H EM; 5.80 A; AO=2-89 # PDB 4V5Y X-ray; 4.45 A; AO/CO=1-89 # PDB 4V64 X-ray; 3.50 A; AO/CO=1-89 # PDB 4V65 EM; 9.00 A; AH=1-89 # PDB 4V66 EM; 9.00 A; AH=1-89 # PDB 4V69 EM; 6.70 A; AO=2-89 # PDB 4V6C X-ray; 3.19 A; AO/CO=1-89 # PDB 4V6D X-ray; 3.81 A; AO/CO=1-89 # PDB 4V6E X-ray; 3.71 A; AO/CO=1-89 # PDB 4V6K EM; 8.25 A; BS=1-89 # PDB 4V6L EM; 13.20 A; AS=1-89 # PDB 4V6M EM; -; O=2-89 # PDB 4V6N EM; 12.10 A; BR=2-89 # PDB 4V6O EM; 14.70 A; AR=2-89 # PDB 4V6P EM; 13.50 A; AR=2-89 # PDB 4V6Q EM; 11.50 A; AR=2-89 # PDB 4V6R EM; 11.50 A; AR=2-89 # PDB 4V6S EM; 13.10 A; BQ=2-89 # PDB 4V6T EM; 8.30 A; AO=2-89 # PDB 4V6V EM; 9.80 A; AO=2-89 # PDB 4V6Y EM; 12.00 A; AO=1-89 # PDB 4V6Z EM; 12.00 A; AO=1-89 # PDB 4V70 EM; 17.00 A; AO=1-89 # PDB 4V71 EM; 20.00 A; AO=1-89 # PDB 4V72 EM; 13.00 A; AO=1-89 # PDB 4V73 EM; 15.00 A; AO=1-89 # PDB 4V74 EM; 17.00 A; AO=1-89 # PDB 4V75 EM; 12.00 A; AO=1-89 # PDB 4V76 EM; 17.00 A; AO=1-89 # PDB 4V77 EM; 17.00 A; AO=1-89 # PDB 4V78 EM; 20.00 A; AO=1-89 # PDB 4V79 EM; 15.00 A; AO=1-89 # PDB 4V7A EM; 9.00 A; AO=1-89 # PDB 4V7B EM; 6.80 A; AO=1-89 # PDB 4V7C EM; 7.60 A; AO=2-89 # PDB 4V7D EM; 7.60 A; BO=2-89 # PDB 4V7I EM; 9.60 A; BO=1-89 # PDB 4V7S X-ray; 3.25 A; AO/CO=2-89 # PDB 4V7T X-ray; 3.19 A; AO/CO=2-89 # PDB 4V7U X-ray; 3.10 A; AO/CO=2-89 # PDB 4V7V X-ray; 3.29 A; AO/CO=2-89 # PDB 4V85 X-ray; 3.20 A; O=1-89 # PDB 4V89 X-ray; 3.70 A; AO=1-89 # PDB 4V9C X-ray; 3.30 A; AO/CO=1-89 # PDB 4V9D X-ray; 3.00 A; AO/BO=2-89 # PDB 4V9O X-ray; 2.90 A; BO/DO/FO/HO=1-89 # PDB 4V9P X-ray; 2.90 A; BO/DO/FO/HO=1-89 # PDB 4WF1 X-ray; 3.09 A; AO/CO=2-89 # PDB 4WWW X-ray; 3.10 A; QO/XO=2-89 # PDB 4YBB X-ray; 2.10 A; AO/BO=2-89 # PDB 5AFI EM; 2.90 A; o=1-89 # PDB 5IQR EM; 3.00 A; t=1-89 # PDB 5IT8 X-ray; 3.12 A; AO/BO=2-89 # PDB 5J5B X-ray; 2.80 A; AO/BO=2-89 # PDB 5J7L X-ray; 3.00 A; AO/BO=2-89 # PDB 5J88 X-ray; 3.32 A; AO/BO=2-89 # PDB 5J8A X-ray; 3.10 A; AO/BO=2-89 # PDB 5J91 X-ray; 2.96 A; AO/BO=2-89 # PDB 5JC9 X-ray; 3.03 A; AO/BO=2-89 # PDB 5JTE EM; 3.60 A; AO=1-89 # PDB 5JU8 EM; 3.60 A; AO=1-89 # PDB 5KCR EM; 3.60 A; 1o=1-89 # PDB 5KCS EM; 3.90 A; 1o=1-89 # PDB 5KPS EM; 3.90 A; 20=1-89 # PDB 5KPV EM; 4.10 A; 19=1-89 # PDB 5KPW EM; 3.90 A; 19=1-89 # PDB 5KPX EM; 3.90 A; 19=1-89 # PDB 5L3P EM; 3.70 A; o=1-89 # PIR B26118 R3EC15 # PROSITE PS00362 RIBOSOMAL_S15 # Pfam PF00312 Ribosomal_S15 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 30S ribosomal protein S15 {ECO:0000255|HAMAP-Rule MF_01343} # RefSeq NP_417634 NC_000913.3 # RefSeq WP_000059466 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein S15P family. {ECO:0000255|HAMAP-Rule MF_01343}. # SMART SM01387 Ribosomal_S15 # SUBUNIT RS15_ECOLI Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA. {ECO 0000269|PubMed 12244297, ECO 0000269|PubMed 12809609, ECO 0000269|PubMed 16272117}. # SUPFAM SSF47060 SSF47060 # TIGRFAMs TIGR00952 S15_bact # eggNOG COG0184 LUCA # eggNOG ENOG4105K77 Bacteria BLAST swissprot:RS15_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RS15_ECOLI BioCyc ECOL316407:JW3134-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3134-MONOMER BioCyc EcoCyc:EG10914-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10914-MONOMER BioCyc MetaCyc:EG10914-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10914-MONOMER COG COG0184 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0184 DIP DIP-47909N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47909N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1007/BF00330967 http://dx.doi.org/10.1007/BF00330967 DOI 10.1016/0014-5793(76)80316-X http://dx.doi.org/10.1016/0014-5793(76)80316-X DOI 10.1016/0378-1119(85)90019-8 http://dx.doi.org/10.1016/0378-1119(85)90019-8 DOI 10.1016/S0092-8674(03)00427-6 http://dx.doi.org/10.1016/S0092-8674(03)00427-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb841 http://dx.doi.org/10.1038/nsb841 DOI 10.1093/nar/12.15.6091 http://dx.doi.org/10.1093/nar/12.15.6091 DOI 10.1093/nar/16.22.10803 http://dx.doi.org/10.1093/nar/16.22.10803 DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pbio.1001731 http://dx.doi.org/10.1371/journal.pbio.1001731 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J02638 http://www.ebi.ac.uk/ena/data/view/J02638 EMBL M14425 http://www.ebi.ac.uk/ena/data/view/M14425 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X00761 http://www.ebi.ac.uk/ena/data/view/X00761 EMBL X01073 http://www.ebi.ac.uk/ena/data/view/X01073 EMBL X13775 http://www.ebi.ac.uk/ena/data/view/X13775 EchoBASE EB0907 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0907 EcoGene EG10914 http://www.ecogene.org/geneInfo.php?eg_id=EG10914 EnsemblBacteria AAC76199 http://www.ensemblgenomes.org/id/AAC76199 EnsemblBacteria AAC76199 http://www.ensemblgenomes.org/id/AAC76199 EnsemblBacteria BAE77211 http://www.ensemblgenomes.org/id/BAE77211 EnsemblBacteria BAE77211 http://www.ensemblgenomes.org/id/BAE77211 EnsemblBacteria BAE77211 http://www.ensemblgenomes.org/id/BAE77211 EnsemblBacteria b3165 http://www.ensemblgenomes.org/id/b3165 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0022627 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022627 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GO_process GO:0006378 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006378 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GO_process GO:0006417 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006417 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_process GO:0006397 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006397 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.10.287.10 http://www.cathdb.info/version/latest/superfamily/1.10.287.10 GeneID 947686 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947686 HAMAP MF_01343_B http://hamap.expasy.org/unirule/MF_01343_B HOGENOM HOG000040097 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000040097&db=HOGENOM6 InParanoid P0ADZ4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADZ4 IntAct P0ADZ4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADZ4* InterPro IPR000589 http://www.ebi.ac.uk/interpro/entry/IPR000589 InterPro IPR005290 http://www.ebi.ac.uk/interpro/entry/IPR005290 InterPro IPR009068 http://www.ebi.ac.uk/interpro/entry/IPR009068 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW3134 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3134 KEGG_Gene eco:b3165 http://www.genome.jp/dbget-bin/www_bget?eco:b3165 KEGG_Orthology KO:K02956 http://www.genome.jp/dbget-bin/www_bget?KO:K02956 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 MINT MINT-1299353 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1299353 OMA TEHFKSH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TEHFKSH PDB 1EG0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1EG0 PDB 2VAZ http://www.ebi.ac.uk/pdbe-srv/view/entry/2VAZ PDB 2YKR http://www.ebi.ac.uk/pdbe-srv/view/entry/2YKR PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 4A2I http://www.ebi.ac.uk/pdbe-srv/view/entry/4A2I PDB 4ADV http://www.ebi.ac.uk/pdbe-srv/view/entry/4ADV PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4V47 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V47 PDB 4V48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V48 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 1EG0 http://www.ebi.ac.uk/pdbsum/1EG0 PDBsum 2VAZ http://www.ebi.ac.uk/pdbsum/2VAZ PDBsum 2YKR http://www.ebi.ac.uk/pdbsum/2YKR PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 4A2I http://www.ebi.ac.uk/pdbsum/4A2I PDBsum 4ADV http://www.ebi.ac.uk/pdbsum/4ADV PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4V47 http://www.ebi.ac.uk/pdbsum/4V47 PDBsum 4V48 http://www.ebi.ac.uk/pdbsum/4V48 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PROSITE PS00362 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00362 PSORT swissprot:RS15_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RS15_ECOLI PSORT-B swissprot:RS15_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RS15_ECOLI PSORT2 swissprot:RS15_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RS15_ECOLI Pfam PF00312 http://pfam.xfam.org/family/PF00312 Phobius swissprot:RS15_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RS15_ECOLI PhylomeDB P0ADZ4 http://phylomedb.org/?seqid=P0ADZ4 ProteinModelPortal P0ADZ4 http://www.proteinmodelportal.org/query/uniprot/P0ADZ4 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 12244297 http://www.ncbi.nlm.nih.gov/pubmed/12244297 PubMed 12809609 http://www.ncbi.nlm.nih.gov/pubmed/12809609 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2432069 http://www.ncbi.nlm.nih.gov/pubmed/2432069 PubMed 24339747 http://www.ncbi.nlm.nih.gov/pubmed/24339747 PubMed 2849753 http://www.ncbi.nlm.nih.gov/pubmed/2849753 PubMed 3005122 http://www.ncbi.nlm.nih.gov/pubmed/3005122 PubMed 6382163 http://www.ncbi.nlm.nih.gov/pubmed/6382163 PubMed 6394953 http://www.ncbi.nlm.nih.gov/pubmed/6394953 PubMed 776686 http://www.ncbi.nlm.nih.gov/pubmed/776686 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417634 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417634 RefSeq WP_000059466 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000059466 SMART SM01387 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01387 SMR P0ADZ4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADZ4 STRING 511145.b3165 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3165&targetmode=cogs STRING COG0184 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0184&targetmode=cogs SUPFAM SSF47060 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47060 TIGRFAMs TIGR00952 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00952 UniProtKB RS15_ECOLI http://www.uniprot.org/uniprot/RS15_ECOLI UniProtKB-AC P0ADZ4 http://www.uniprot.org/uniprot/P0ADZ4 charge swissprot:RS15_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RS15_ECOLI eggNOG COG0184 http://eggnogapi.embl.de/nog_data/html/tree/COG0184 eggNOG ENOG4105K77 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K77 epestfind swissprot:RS15_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RS15_ECOLI garnier swissprot:RS15_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RS15_ECOLI helixturnhelix swissprot:RS15_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RS15_ECOLI hmoment swissprot:RS15_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RS15_ECOLI iep swissprot:RS15_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RS15_ECOLI inforesidue swissprot:RS15_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RS15_ECOLI octanol swissprot:RS15_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RS15_ECOLI pepcoil swissprot:RS15_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RS15_ECOLI pepdigest swissprot:RS15_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RS15_ECOLI pepinfo swissprot:RS15_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RS15_ECOLI pepnet swissprot:RS15_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RS15_ECOLI pepstats swissprot:RS15_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RS15_ECOLI pepwheel swissprot:RS15_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RS15_ECOLI pepwindow swissprot:RS15_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RS15_ECOLI sigcleave swissprot:RS15_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RS15_ECOLI ## Database ID URL or Descriptions # BioGrid 4262874 304 # DISRUPTION PHENOTYPE Not required for induction of, or recovery from, contact-dependent growth inhibition (CDI). {ECO:0000269|PubMed 19124575}. # DOMAIN PSPA_ECOLI All four putative helical domains of PspA are critical for the formation of the 36-mer. In contrast, not all four helical domains are required for the formation of the inhibitory PspA-PspF complex. {ECO 0000269|PubMed 19804784}. # EcoGene EG10776 pspA # FUNCTION PSPA_ECOLI The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions. PspA negatively regulates expression of the pspABCDE promoter and of pspG through negative regulation of the psp-specific transcriptional activator PspF. Is also required for membrane integrity, efficient translocation and maintenance of the proton motive force. {ECO 0000269|PubMed 10629175, ECO 0000269|PubMed 15485810, ECO 0000269|PubMed 1712397, ECO 0000269|PubMed 19804784, ECO 0000269|PubMed 8598199}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0031234 extrinsic component of cytoplasmic side of plasma membrane; IDA:EcoCyc. # GO_component GO:0060187 cell pole; IDA:EcoCyc. # GO_function GO:0005543 phospholipid binding; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0009271 phage shock; IEP:EcoliWiki. # GO_process GO:0009408 response to heat; IEP:EcoliWiki. # GO_process GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008289 lipid binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0044403 symbiosis, encompassing mutualism through parasitism # INDUCTION PSPA_ECOLI By heat, ethanol, osmotic shock and infection by filamentous bacteriophages (PubMed 1712397). Induced during contact-dependent growth inhibition (CDI), but not during recovery from CDI (PubMed 19124575). {ECO 0000269|PubMed 1712397, ECO 0000269|PubMed 19124575}. # IntAct P0AFM6 4 # InterPro IPR007157 PspA_IM30 # InterPro IPR014319 Phageshock_PspA # Organism PSPA_ECOLI Escherichia coli (strain K12) # PATRIC 32117880 VBIEscCol129921_1360 # PDB 4WHE X-ray; 1.80 A; A=1-144 # PIR C64879 C64879 # Pfam PF04012 PspA_IM30 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PSPA_ECOLI Phage shock protein A # RefSeq NP_415820 NC_000913.3 # RefSeq WP_000511025 NZ_LN832404.1 # SIMILARITY Belongs to the PspA/IM30 family. {ECO 0000305}. # SUBCELLULAR LOCATION PSPA_ECOLI Cytoplasm {ECO 0000269|PubMed 19555453}. Cell inner membrane {ECO 0000269|PubMed 19555453}; Peripheral membrane protein {ECO 0000269|PubMed 19555453}; Cytoplasmic side {ECO 0000269|PubMed 19555453}. Note=Localizes at both cell poles and along the length of the cell. # SUBUNIT PSPA_ECOLI Exists in at least two different oligomeric assemblies. Regulatory function involves the formation of a complex with PspF, which is composed of around 6 PspF subunits and 6 PspA subunits. Maintenance of membrane integrity involves the formation of a 36- mer ring complex. Interacts with PspB and PspC. {ECO 0000269|PubMed 12562786, ECO 0000269|PubMed 14688274, ECO 0000269|PubMed 19804784}. # TIGRFAMs TIGR02977 phageshock_pspA # eggNOG COG1842 LUCA # eggNOG ENOG41087YS Bacteria BLAST swissprot:PSPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PSPA_ECOLI BioCyc ECOL316407:JW1297-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1297-MONOMER BioCyc EcoCyc:EG10776-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10776-MONOMER COG COG1842 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1842 DIP DIP-10587N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10587N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0022-2836(91)90379-K http://dx.doi.org/10.1016/0022-2836(91)90379-K DOI 10.1016/j.jmb.2009.09.055 http://dx.doi.org/10.1016/j.jmb.2009.09.055 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M307889200 http://dx.doi.org/10.1074/jbc.M307889200 DOI 10.1074/jbc.M408994200 http://dx.doi.org/10.1074/jbc.M408994200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1099/00221287-144-2-353 http://dx.doi.org/10.1099/00221287-144-2-353 DOI 10.1099/13500872-140-8-1937 http://dx.doi.org/10.1099/13500872-140-8-1937 DOI 10.1111/j.1365-2958.2009.06776.x http://dx.doi.org/10.1111/j.1365-2958.2009.06776.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01437-08 http://dx.doi.org/10.1128/JB.01437-08 DOI 10.1128/JB.182.2.311-319.2000 http://dx.doi.org/10.1128/JB.182.2.311-319.2000 DOI 10.1128/JB.185.4.1174-1180.2003 http://dx.doi.org/10.1128/JB.185.4.1174-1180.2003 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X57560 http://www.ebi.ac.uk/ena/data/view/X57560 EchoBASE EB0769 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0769 EcoGene EG10776 http://www.ecogene.org/geneInfo.php?eg_id=EG10776 EnsemblBacteria AAC74386 http://www.ensemblgenomes.org/id/AAC74386 EnsemblBacteria AAC74386 http://www.ensemblgenomes.org/id/AAC74386 EnsemblBacteria BAA14873 http://www.ensemblgenomes.org/id/BAA14873 EnsemblBacteria BAA14873 http://www.ensemblgenomes.org/id/BAA14873 EnsemblBacteria BAA14873 http://www.ensemblgenomes.org/id/BAA14873 EnsemblBacteria b1304 http://www.ensemblgenomes.org/id/b1304 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0031234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031234 GO_component GO:0060187 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060187 GO_function GO:0005543 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005543 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0009271 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009271 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GO_process GO:0043433 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043433 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0044403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403 GeneID 945887 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945887 HOGENOM HOG000227267 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000227267&db=HOGENOM6 InParanoid P0AFM6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFM6 IntAct P0AFM6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFM6* InterPro IPR007157 http://www.ebi.ac.uk/interpro/entry/IPR007157 InterPro IPR014319 http://www.ebi.ac.uk/interpro/entry/IPR014319 KEGG_Gene ecj:JW1297 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1297 KEGG_Gene eco:b1304 http://www.genome.jp/dbget-bin/www_bget?eco:b1304 KEGG_Orthology KO:K03969 http://www.genome.jp/dbget-bin/www_bget?KO:K03969 OMA QKTIIMR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QKTIIMR PDB 4WHE http://www.ebi.ac.uk/pdbe-srv/view/entry/4WHE PDBsum 4WHE http://www.ebi.ac.uk/pdbsum/4WHE PSORT swissprot:PSPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PSPA_ECOLI PSORT-B swissprot:PSPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PSPA_ECOLI PSORT2 swissprot:PSPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PSPA_ECOLI Pfam PF04012 http://pfam.xfam.org/family/PF04012 Phobius swissprot:PSPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PSPA_ECOLI PhylomeDB P0AFM6 http://phylomedb.org/?seqid=P0AFM6 ProteinModelPortal P0AFM6 http://www.proteinmodelportal.org/query/uniprot/P0AFM6 PubMed 10629175 http://www.ncbi.nlm.nih.gov/pubmed/10629175 PubMed 12562786 http://www.ncbi.nlm.nih.gov/pubmed/12562786 PubMed 14688274 http://www.ncbi.nlm.nih.gov/pubmed/14688274 PubMed 15485810 http://www.ncbi.nlm.nih.gov/pubmed/15485810 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1712397 http://www.ncbi.nlm.nih.gov/pubmed/1712397 PubMed 19124575 http://www.ncbi.nlm.nih.gov/pubmed/19124575 PubMed 19555453 http://www.ncbi.nlm.nih.gov/pubmed/19555453 PubMed 19804784 http://www.ncbi.nlm.nih.gov/pubmed/19804784 PubMed 7921245 http://www.ncbi.nlm.nih.gov/pubmed/7921245 PubMed 8598199 http://www.ncbi.nlm.nih.gov/pubmed/8598199 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9493373 http://www.ncbi.nlm.nih.gov/pubmed/9493373 RefSeq NP_415820 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415820 RefSeq WP_000511025 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000511025 SMR P0AFM6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFM6 STRING 511145.b1304 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1304&targetmode=cogs STRING COG1842 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1842&targetmode=cogs TIGRFAMs TIGR02977 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02977 UniProtKB PSPA_ECOLI http://www.uniprot.org/uniprot/PSPA_ECOLI UniProtKB-AC P0AFM6 http://www.uniprot.org/uniprot/P0AFM6 charge swissprot:PSPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PSPA_ECOLI eggNOG COG1842 http://eggnogapi.embl.de/nog_data/html/tree/COG1842 eggNOG ENOG41087YS http://eggnogapi.embl.de/nog_data/html/tree/ENOG41087YS epestfind swissprot:PSPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PSPA_ECOLI garnier swissprot:PSPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PSPA_ECOLI helixturnhelix swissprot:PSPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PSPA_ECOLI hmoment swissprot:PSPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PSPA_ECOLI iep swissprot:PSPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PSPA_ECOLI inforesidue swissprot:PSPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PSPA_ECOLI octanol swissprot:PSPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PSPA_ECOLI pepcoil swissprot:PSPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PSPA_ECOLI pepdigest swissprot:PSPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PSPA_ECOLI pepinfo swissprot:PSPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PSPA_ECOLI pepnet swissprot:PSPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PSPA_ECOLI pepstats swissprot:PSPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PSPA_ECOLI pepwheel swissprot:PSPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PSPA_ECOLI pepwindow swissprot:PSPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PSPA_ECOLI sigcleave swissprot:PSPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PSPA_ECOLI ## Database ID URL or Descriptions # AltName TSAE_ECOLI t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=169 uM for ATP {ECO 0000269|PubMed:19376873}; Note=kcat is 0.0026 sec(-1) for ATP hydrolysis.; # BioGrid 4262705 136 # CAUTION The well-known t(6)A modification appears to be a hydrolyzed artifact of natural cyclic t(6)A (ct(6)A) that occurs during the preparation and handling of tRNA in E.coli and many other species (PubMed:23242255). In these species, the t(6)A modification is processed further by dehydration into ct(6)A, a reaction catalyzed by TcdA. {ECO 0000305}. # DISRUPTION PHENOTYPE Appears essential for growth, since no null mutants can be obtained. Conditional depletion of this gene leads to very elongated cells, 1.5 to 1.75 times wider than wild-type, displaying an unusual distribution of the DNA, which appears to be located around the periphery of the cell rather than throughout the cytoplasm. The TsaE depletion phenotype is suppressed by overexpressing the response regulator RstA. {ECO:0000269|PubMed 19376873}. # EcoGene EG11757 tsaE # FUNCTION TSAE_ECOLI Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD. Displays ATPase activity in vitro. {ECO 0000269|PubMed 22378793}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016887 ATPase activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0043531 ADP binding; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0002949 tRNA threonylcarbamoyladenosine modification; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # Gene3D 3.40.50.300 -; 1. # IntAct P0AF67 23 # InterPro IPR003442 T6A_TsaE # InterPro IPR027417 P-loop_NTPase # MISCELLANEOUS TsaBCDE are necessary and sufficient for tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification in vitro in E.coli. {ECO:0000305|PubMed 22378793}. # Organism TSAE_ECOLI Escherichia coli (strain K12) # PATRIC 32123909 VBIEscCol129921_4299 # PIR S56393 S56393 # Pfam PF02367 TsaE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TSAE_ECOLI tRNA threonylcarbamoyladenosine biosynthesis protein TsaE # RefSeq NP_418589 NC_000913.3 # RefSeq WP_000981977 NZ_LN832404.1 # SIMILARITY Belongs to the TsaE family. {ECO 0000305}. # SUBCELLULAR LOCATION TSAE_ECOLI Cytoplasm {ECO 0000269|PubMed 19376873}. # SUBUNIT TSAE_ECOLI Homodimer. Interacts with TsaB. {ECO 0000269|PubMed 19376873, ECO 0000269|PubMed 22378793}. # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR00150 T6A_YjeE # eggNOG COG0802 LUCA # eggNOG ENOG4105K8N Bacteria BLAST swissprot:TSAE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TSAE_ECOLI BioCyc ECOL316407:JW4126-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4126-MONOMER BioCyc EcoCyc:EG11757-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11757-MONOMER BioCyc MetaCyc:EG11757-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11757-MONOMER COG COG0802 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0802 DIP DIP-47867N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47867N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M112.344028 http://dx.doi.org/10.1074/jbc.M112.344028 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1111/j.1365-2958.1994.tb00300.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb00300.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00136-09 http://dx.doi.org/10.1128/JB.00136-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19346 http://www.ebi.ac.uk/ena/data/view/L19346 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB1707 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1707 EcoGene EG11757 http://www.ecogene.org/geneInfo.php?eg_id=EG11757 EnsemblBacteria AAC77125 http://www.ensemblgenomes.org/id/AAC77125 EnsemblBacteria AAC77125 http://www.ensemblgenomes.org/id/AAC77125 EnsemblBacteria BAE78169 http://www.ensemblgenomes.org/id/BAE78169 EnsemblBacteria BAE78169 http://www.ensemblgenomes.org/id/BAE78169 EnsemblBacteria BAE78169 http://www.ensemblgenomes.org/id/BAE78169 EnsemblBacteria b4168 http://www.ensemblgenomes.org/id/b4168 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0043531 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043531 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0002949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002949 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948684 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948684 HOGENOM HOG000052238 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000052238&db=HOGENOM6 InParanoid P0AF67 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AF67 IntAct P0AF67 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AF67* InterPro IPR003442 http://www.ebi.ac.uk/interpro/entry/IPR003442 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Gene ecj:JW4126 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4126 KEGG_Gene eco:b4168 http://www.genome.jp/dbget-bin/www_bget?eco:b4168 KEGG_Orthology KO:K06925 http://www.genome.jp/dbget-bin/www_bget?KO:K06925 MINT MINT-1256268 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1256268 OMA LDIDIRY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LDIDIRY PSORT swissprot:TSAE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TSAE_ECOLI PSORT-B swissprot:TSAE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TSAE_ECOLI PSORT2 swissprot:TSAE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TSAE_ECOLI Pfam PF02367 http://pfam.xfam.org/family/PF02367 Phobius swissprot:TSAE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TSAE_ECOLI PhylomeDB P0AF67 http://phylomedb.org/?seqid=P0AF67 ProteinModelPortal P0AF67 http://www.proteinmodelportal.org/query/uniprot/P0AF67 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19376873 http://www.ncbi.nlm.nih.gov/pubmed/19376873 PubMed 22378793 http://www.ncbi.nlm.nih.gov/pubmed/22378793 PubMed 7511774 http://www.ncbi.nlm.nih.gov/pubmed/7511774 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418589 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418589 RefSeq WP_000981977 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000981977 SMR P0AF67 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AF67 STRING 511145.b4168 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4168&targetmode=cogs STRING COG0802 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0802&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR00150 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00150 UniProtKB TSAE_ECOLI http://www.uniprot.org/uniprot/TSAE_ECOLI UniProtKB-AC P0AF67 http://www.uniprot.org/uniprot/P0AF67 charge swissprot:TSAE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TSAE_ECOLI eggNOG COG0802 http://eggnogapi.embl.de/nog_data/html/tree/COG0802 eggNOG ENOG4105K8N http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K8N epestfind swissprot:TSAE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TSAE_ECOLI garnier swissprot:TSAE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TSAE_ECOLI helixturnhelix swissprot:TSAE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TSAE_ECOLI hmoment swissprot:TSAE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TSAE_ECOLI iep swissprot:TSAE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TSAE_ECOLI inforesidue swissprot:TSAE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TSAE_ECOLI octanol swissprot:TSAE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TSAE_ECOLI pepcoil swissprot:TSAE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TSAE_ECOLI pepdigest swissprot:TSAE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TSAE_ECOLI pepinfo swissprot:TSAE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TSAE_ECOLI pepnet swissprot:TSAE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TSAE_ECOLI pepstats swissprot:TSAE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TSAE_ECOLI pepwheel swissprot:TSAE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TSAE_ECOLI pepwindow swissprot:TSAE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TSAE_ECOLI sigcleave swissprot:TSAE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TSAE_ECOLI ## Database ID URL or Descriptions # BioGrid 4259560 12 # DISRUPTION PHENOTYPE Mutant shows decreased biofilm dispersal. Deletion increases the cyclic-di GMP concentration in the cell. {ECO:0000269|PubMed 21059164}. # EcoGene EG12528 bdcA # FUNCTION BDCA_ECOLI Increases biofilm dispersal. Acts by binding directly to the signaling molecule cyclic-di-GMP, which decreases the intracellular concentration of cyclic-di-GMP and leads to biofilm dispersal. Also controls other biofilm-related phenotypes such as cell motility, cell size, cell aggregation and production of extracellular DNA and extracellular polysaccharides (EPS). Does not act as a phosphodiesterase. {ECO 0000269|PubMed 21059164}. # GO_function GO:0016491 oxidoreductase activity; IEA:InterPro. # GO_function GO:0035438 cyclic-di-GMP binding; IDA:EcoCyc. # GO_function GO:0070402 NADPH binding; IDA:EcoCyc. # GO_process GO:0044010 single-species biofilm formation; IMP:EcoCyc. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.720 -; 1. # INDUCTION Expression is time dependent in biofilms and is controlled by BdcR. {ECO:0000269|PubMed 21059164}. # InterPro IPR002347 SDR_fam # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR020904 Sc_DH/Rdtase_CS # Organism BDCA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR24322 PTHR24322; 2 # PATRIC 32124071 VBIEscCol129921_4380 # PIR D65237 D65237 # PRINTS PR00080 SDRFAMILY # PRINTS PR00081 GDHRDH # PROSITE PS00061 ADH_SHORT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BDCA_ECOLI Cyclic-di-GMP-binding biofilm dispersal mediator protein # RefSeq NP_418670 NC_000913.3 # RefSeq WP_000500727 NZ_CP014272.1 # SIMILARITY Belongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO 0000305}. # SUPFAM SSF51735 SSF51735 # eggNOG COG1028 LUCA # eggNOG ENOG4105F6U Bacteria BLAST swissprot:BDCA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BDCA_ECOLI BioCyc ECOL316407:JW4207-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4207-MONOMER BioCyc EcoCyc:G7880-MONOMER http://biocyc.org/getid?id=EcoCyc:G7880-MONOMER DIP DIP-12604N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12604N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1111/j.1462-2920.2010.02368.x http://dx.doi.org/10.1111/j.1462-2920.2010.02368.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2418 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2418 EcoGene EG12528 http://www.ecogene.org/geneInfo.php?eg_id=EG12528 EnsemblBacteria AAC77206 http://www.ensemblgenomes.org/id/AAC77206 EnsemblBacteria AAC77206 http://www.ensemblgenomes.org/id/AAC77206 EnsemblBacteria BAE78247 http://www.ensemblgenomes.org/id/BAE78247 EnsemblBacteria BAE78247 http://www.ensemblgenomes.org/id/BAE78247 EnsemblBacteria BAE78247 http://www.ensemblgenomes.org/id/BAE78247 EnsemblBacteria b4249 http://www.ensemblgenomes.org/id/b4249 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0035438 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035438 GO_function GO:0070402 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070402 GO_process GO:0044010 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044010 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 948765 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948765 InParanoid P39333 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39333 IntAct P39333 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39333* InterPro IPR002347 http://www.ebi.ac.uk/interpro/entry/IPR002347 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR020904 http://www.ebi.ac.uk/interpro/entry/IPR020904 KEGG_Gene ecj:JW4207 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4207 KEGG_Gene eco:b4249 http://www.genome.jp/dbget-bin/www_bget?eco:b4249 OMA TWYCALE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TWYCALE PANTHER PTHR24322 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24322 PRINTS PR00080 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00080 PRINTS PR00081 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00081 PROSITE PS00061 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00061 PSORT swissprot:BDCA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BDCA_ECOLI PSORT-B swissprot:BDCA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BDCA_ECOLI PSORT2 swissprot:BDCA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BDCA_ECOLI Phobius swissprot:BDCA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BDCA_ECOLI PhylomeDB P39333 http://phylomedb.org/?seqid=P39333 ProteinModelPortal P39333 http://www.proteinmodelportal.org/query/uniprot/P39333 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21059164 http://www.ncbi.nlm.nih.gov/pubmed/21059164 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418670 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418670 RefSeq WP_000500727 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000500727 SMR P39333 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39333 STRING 511145.b4249 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4249&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB BDCA_ECOLI http://www.uniprot.org/uniprot/BDCA_ECOLI UniProtKB-AC P39333 http://www.uniprot.org/uniprot/P39333 charge swissprot:BDCA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BDCA_ECOLI eggNOG COG1028 http://eggnogapi.embl.de/nog_data/html/tree/COG1028 eggNOG ENOG4105F6U http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F6U epestfind swissprot:BDCA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BDCA_ECOLI garnier swissprot:BDCA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BDCA_ECOLI helixturnhelix swissprot:BDCA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BDCA_ECOLI hmoment swissprot:BDCA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BDCA_ECOLI iep swissprot:BDCA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BDCA_ECOLI inforesidue swissprot:BDCA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BDCA_ECOLI octanol swissprot:BDCA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BDCA_ECOLI pepcoil swissprot:BDCA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BDCA_ECOLI pepdigest swissprot:BDCA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BDCA_ECOLI pepinfo swissprot:BDCA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BDCA_ECOLI pepnet swissprot:BDCA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BDCA_ECOLI pepstats swissprot:BDCA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BDCA_ECOLI pepwheel swissprot:BDCA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BDCA_ECOLI pepwindow swissprot:BDCA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BDCA_ECOLI sigcleave swissprot:BDCA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BDCA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259695 204 # EcoGene EG12200 yegD # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GOslim_function GO:0043167 ion binding # IntAct P36928 6 # InterPro IPR013126 Hsp_70_fam # InterPro IPR018181 Heat_shock_70_CS # KEGG_Brite ko02000 Transporters # KEGG_Brite ko03110 Chaperones and folding catalysts # Organism YEGD_ECOLI Escherichia coli (strain K12) # PATRIC 32119471 VBIEscCol129921_2146 # PIR D64973 D64973 # PROSITE PS00329 HSP70_2 # Pfam PF00012 HSP70; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEGD_ECOLI Uncharacterized chaperone protein YegD # RefSeq NP_416573 NC_000913.3 # RefSeq WP_000469708 NZ_LN832404.1 # SIMILARITY Belongs to the heat shock protein 70 family. {ECO 0000305}. # eggNOG COG0443 LUCA # eggNOG ENOG4105R8A Bacteria BLAST swissprot:YEGD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEGD_ECOLI BioCyc ECOL316407:JW2054-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2054-MONOMER BioCyc EcoCyc:EG12200-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12200-MONOMER COG COG0443 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0443 DOI 10.1016/0968-0004(94)90067-1 http://dx.doi.org/10.1016/0968-0004(94)90067-1 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K02498 http://www.ebi.ac.uk/ena/data/view/K02498 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2116 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2116 EcoGene EG12200 http://www.ecogene.org/geneInfo.php?eg_id=EG12200 EnsemblBacteria AAC75130 http://www.ensemblgenomes.org/id/AAC75130 EnsemblBacteria AAC75130 http://www.ensemblgenomes.org/id/AAC75130 EnsemblBacteria BAA15927 http://www.ensemblgenomes.org/id/BAA15927 EnsemblBacteria BAA15927 http://www.ensemblgenomes.org/id/BAA15927 EnsemblBacteria BAA15927 http://www.ensemblgenomes.org/id/BAA15927 EnsemblBacteria b2069 http://www.ensemblgenomes.org/id/b2069 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GeneID 947234 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947234 HOGENOM HOG000255689 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000255689&db=HOGENOM6 InParanoid P36928 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P36928 IntAct P36928 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P36928* InterPro IPR013126 http://www.ebi.ac.uk/interpro/entry/IPR013126 InterPro IPR018181 http://www.ebi.ac.uk/interpro/entry/IPR018181 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW2054 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2054 KEGG_Gene eco:b2069 http://www.genome.jp/dbget-bin/www_bget?eco:b2069 KEGG_Orthology KO:K04046 http://www.genome.jp/dbget-bin/www_bget?KO:K04046 OMA HEYLEGY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HEYLEGY PROSITE PS00329 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00329 PSORT swissprot:YEGD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEGD_ECOLI PSORT-B swissprot:YEGD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEGD_ECOLI PSORT2 swissprot:YEGD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEGD_ECOLI Pfam PF00012 http://pfam.xfam.org/family/PF00012 Phobius swissprot:YEGD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEGD_ECOLI PhylomeDB P36928 http://phylomedb.org/?seqid=P36928 ProteinModelPortal P36928 http://www.proteinmodelportal.org/query/uniprot/P36928 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6094528 http://www.ncbi.nlm.nih.gov/pubmed/6094528 PubMed 7940673 http://www.ncbi.nlm.nih.gov/pubmed/7940673 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416573 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416573 RefSeq WP_000469708 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000469708 STRING 511145.b2069 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2069&targetmode=cogs STRING COG0443 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0443&targetmode=cogs UniProtKB YEGD_ECOLI http://www.uniprot.org/uniprot/YEGD_ECOLI UniProtKB-AC P36928 http://www.uniprot.org/uniprot/P36928 charge swissprot:YEGD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEGD_ECOLI eggNOG COG0443 http://eggnogapi.embl.de/nog_data/html/tree/COG0443 eggNOG ENOG4105R8A http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105R8A epestfind swissprot:YEGD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEGD_ECOLI garnier swissprot:YEGD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEGD_ECOLI helixturnhelix swissprot:YEGD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEGD_ECOLI hmoment swissprot:YEGD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEGD_ECOLI iep swissprot:YEGD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEGD_ECOLI inforesidue swissprot:YEGD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEGD_ECOLI octanol swissprot:YEGD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEGD_ECOLI pepcoil swissprot:YEGD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEGD_ECOLI pepdigest swissprot:YEGD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEGD_ECOLI pepinfo swissprot:YEGD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEGD_ECOLI pepnet swissprot:YEGD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEGD_ECOLI pepstats swissprot:YEGD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEGD_ECOLI pepwheel swissprot:YEGD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEGD_ECOLI pepwindow swissprot:YEGD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEGD_ECOLI sigcleave swissprot:YEGD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEGD_ECOLI ## Database ID URL or Descriptions # AltName HFQ_ECOLI HF-1 # AltName HFQ_ECOLI Host factor-I protein # BioGrid 4261250 247 # CDD cd01716 Hfq # DISRUPTION PHENOTYPE HFQ_ECOLI Deletion of hfq seems to lead to a significant translational fidelity problem. Deletion increases persister cell formation (PubMed 19909729). Deletion abolishes the antitoxin activity of sRNA antitoxin RalA, preventing it from neutralizing toxin RalR (PubMed 24748661). {ECO 0000269|PubMed 19909729, ECO 0000269|PubMed 24748661}. # EcoGene EG10438 hfq # FUNCTION HFQ_ECOLI RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Involved in the regulation of stress responses mediated by the sigma factors RpoS, sigma-E and sigma-32 (PubMed 17158661). Binds with high specificity to tRNAs (PubMed 18230766). Binds sRNA antitoxin RalA (PubMed 24748661). In vitro, stimulates synthesis of long tails by poly(A) polymerase I (PubMed 10677490). Required for RNA phage Qbeta replication (PubMed 805130). Seems to play a role in persister cell formation; upon overexpression decreases persister cell formation while deletion increases persister formation (PubMed 19909729). {ECO 0000269|PubMed 10677490, ECO 0000269|PubMed 17158661, ECO 0000269|PubMed 18230766, ECO 0000269|PubMed 19909729, ECO 0000269|PubMed 24748661, ECO 0000269|PubMed 805130}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003681 bent DNA binding; IDA:EcoliWiki. # GO_function GO:0003723 RNA binding; IDA:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:InterPro. # GO_process GO:0040033 negative regulation of translation, ncRNA-mediated; IEP:EcoliWiki. # GO_process GO:0045975 positive regulation of translation, ncRNA-mediated; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0003723 RNA binding # GOslim_process GO:0008150 biological_process # HAMAP MF_00436 Hfq # INTERACTION HFQ_ECOLI P0AG30 rho; NbExp=4; IntAct=EBI-547637, EBI-545468; # IntAct P0A6X3 77 # InterPro IPR005001 Hfq # InterPro IPR010920 LSM_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko03036 Chromosome # KEGG_Pathway ko03018 RNA degradation # Organism HFQ_ECOLI Escherichia coli (strain K12) # PANTHER PTHR34772:SF1 PTHR34772:SF1 # PATRIC 32123917 VBIEscCol129921_4303 # PDB 1HK9 X-ray; 2.15 A; A/B/C/D/E/F=1-72 # PDB 1M7C Model; -; A/B/C/D/E/F=9-76 # PDB 1OOU Model; -; A/B/C/D/E/F=6-64 # PDB 1OOV Model; -; A/B/C/D/E/F=6-64 # PDB 2Y90 X-ray; 2.25 A; A=1-102 # PDB 2YHT X-ray; 2.90 A; A/B/C/D/E/F/G/H/I/J/K/L=1-72 # PDB 3GIB X-ray; 2.40 A; A/B/C=2-69 # PDB 3QHS X-ray; 2.85 A; A/B/C/D/E/F/G/H/I/J/K/L=1-102 # PDB 3QO3 X-ray; 2.15 A; A/B/C/D/E/F=1-65 # PDB 3RER X-ray; 1.70 A; A/B/C/D/E/F=1-65 # PDB 3RES X-ray; 2.00 A; A/B/C/D/E/F/G/H/I/J/K/L=1-65 # PDB 3VU3 X-ray; 2.85 A; C/D/E/F/G/H=1-102 # PDB 4JRI X-ray; 1.83 A; A/B/C/D=2-69 # PDB 4JRK X-ray; 1.89 A; A/B/C=2-69 # PDB 4JUV X-ray; 2.19 A; A/B/C/D/E/F=2-69 # PDB 4RCB X-ray; 1.63 A; A=5-71 # PDB 4RCC X-ray; 1.98 A; A=5-71 # PDB 4V2S X-ray; 3.48 A; A/B/C/D/E/F=1-102 # PIR S26832 S56397 # Pfam PF17209 Hfq # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RNA-binding protein Hfq {ECO:0000255|HAMAP-Rule MF_00436} # RefSeq NP_418593 NC_000913.3 # RefSeq WP_001051883 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA24175.1; Type=Frameshift; Positions=72; Evidence={ECO 0000305}; # SIMILARITY Belongs to the Hfq family. {ECO:0000255|HAMAP- Rule MF_00436}. # SUBUNIT HFQ_ECOLI Homohexamer (PubMed 12853626). Interacts with H-NS (PubMed 11222598). {ECO 0000255|HAMAP-Rule MF_00436, ECO 0000269|PubMed 12853626, ECO 0000269|PubMed 2020545}. # SUPFAM SSF50182 SSF50182 # TIGRFAMs TIGR02383 Hfq # eggNOG COG1923 LUCA # eggNOG ENOG4105KW8 Bacteria BLAST swissprot:HFQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HFQ_ECOLI BioCyc ECOL316407:JW4130-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4130-MONOMER BioCyc EcoCyc:EG10438-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10438-MONOMER COG COG1923 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1923 DIP DIP-36047N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36047N DOI 10.1006/bbrc.1997.7013 http://dx.doi.org/10.1006/bbrc.1997.7013 DOI 10.1016/j.bbrc.2009.11.033 http://dx.doi.org/10.1016/j.bbrc.2009.11.033 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.040549897 http://dx.doi.org/10.1073/pnas.040549897 DOI 10.1073/pnas.90.22.10866 http://dx.doi.org/10.1073/pnas.90.22.10866 DOI 10.1093/nar/19.5.1063 http://dx.doi.org/10.1093/nar/19.5.1063 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1093/nar/gkg480 http://dx.doi.org/10.1093/nar/gkg480 DOI 10.1093/nar/gku279 http://dx.doi.org/10.1093/nar/gku279 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01243-06 http://dx.doi.org/10.1128/JB.01243-06 DOI 10.1128/JB.183.6.1997-2005.2001 http://dx.doi.org/10.1128/JB.183.6.1997-2005.2001 DOI 10.1261/rna.531408 http://dx.doi.org/10.1261/rna.531408 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D00743 http://www.ebi.ac.uk/ena/data/view/D00743 EMBL M63655 http://www.ebi.ac.uk/ena/data/view/M63655 EMBL U00005 http://www.ebi.ac.uk/ena/data/view/U00005 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB0433 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0433 EcoGene EG10438 http://www.ecogene.org/geneInfo.php?eg_id=EG10438 EnsemblBacteria AAC77129 http://www.ensemblgenomes.org/id/AAC77129 EnsemblBacteria AAC77129 http://www.ensemblgenomes.org/id/AAC77129 EnsemblBacteria BAE78173 http://www.ensemblgenomes.org/id/BAE78173 EnsemblBacteria BAE78173 http://www.ensemblgenomes.org/id/BAE78173 EnsemblBacteria BAE78173 http://www.ensemblgenomes.org/id/BAE78173 EnsemblBacteria b4172 http://www.ensemblgenomes.org/id/b4172 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003681 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003681 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0040033 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040033 GO_process GO:0045975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045975 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 948689 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948689 HAMAP MF_00436 http://hamap.expasy.org/unirule/MF_00436 HOGENOM HOG000004931 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000004931&db=HOGENOM6 InParanoid P0A6X3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6X3 IntAct P0A6X3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6X3* InterPro IPR005001 http://www.ebi.ac.uk/interpro/entry/IPR005001 InterPro IPR010920 http://www.ebi.ac.uk/interpro/entry/IPR010920 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene ecj:JW4130 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4130 KEGG_Gene eco:b4172 http://www.genome.jp/dbget-bin/www_bget?eco:b4172 KEGG_Orthology KO:K03666 http://www.genome.jp/dbget-bin/www_bget?KO:K03666 KEGG_Pathway ko03018 http://www.genome.jp/kegg-bin/show_pathway?ko03018 MINT MINT-8200668 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8200668 OMA RDGHAQL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RDGHAQL PANTHER PTHR34772:SF1 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34772:SF1 PDB 1HK9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1HK9 PDB 1M7C http://www.ebi.ac.uk/pdbe-srv/view/entry/1M7C PDB 1OOU http://www.ebi.ac.uk/pdbe-srv/view/entry/1OOU PDB 1OOV http://www.ebi.ac.uk/pdbe-srv/view/entry/1OOV PDB 2Y90 http://www.ebi.ac.uk/pdbe-srv/view/entry/2Y90 PDB 2YHT http://www.ebi.ac.uk/pdbe-srv/view/entry/2YHT PDB 3GIB http://www.ebi.ac.uk/pdbe-srv/view/entry/3GIB PDB 3QHS http://www.ebi.ac.uk/pdbe-srv/view/entry/3QHS PDB 3QO3 http://www.ebi.ac.uk/pdbe-srv/view/entry/3QO3 PDB 3RER http://www.ebi.ac.uk/pdbe-srv/view/entry/3RER PDB 3RES http://www.ebi.ac.uk/pdbe-srv/view/entry/3RES PDB 3VU3 http://www.ebi.ac.uk/pdbe-srv/view/entry/3VU3 PDB 4JRI http://www.ebi.ac.uk/pdbe-srv/view/entry/4JRI PDB 4JRK http://www.ebi.ac.uk/pdbe-srv/view/entry/4JRK PDB 4JUV http://www.ebi.ac.uk/pdbe-srv/view/entry/4JUV PDB 4RCB http://www.ebi.ac.uk/pdbe-srv/view/entry/4RCB PDB 4RCC http://www.ebi.ac.uk/pdbe-srv/view/entry/4RCC PDB 4V2S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V2S PDBsum 1HK9 http://www.ebi.ac.uk/pdbsum/1HK9 PDBsum 1M7C http://www.ebi.ac.uk/pdbsum/1M7C PDBsum 1OOU http://www.ebi.ac.uk/pdbsum/1OOU PDBsum 1OOV http://www.ebi.ac.uk/pdbsum/1OOV PDBsum 2Y90 http://www.ebi.ac.uk/pdbsum/2Y90 PDBsum 2YHT http://www.ebi.ac.uk/pdbsum/2YHT PDBsum 3GIB http://www.ebi.ac.uk/pdbsum/3GIB PDBsum 3QHS http://www.ebi.ac.uk/pdbsum/3QHS PDBsum 3QO3 http://www.ebi.ac.uk/pdbsum/3QO3 PDBsum 3RER http://www.ebi.ac.uk/pdbsum/3RER PDBsum 3RES http://www.ebi.ac.uk/pdbsum/3RES PDBsum 3VU3 http://www.ebi.ac.uk/pdbsum/3VU3 PDBsum 4JRI http://www.ebi.ac.uk/pdbsum/4JRI PDBsum 4JRK http://www.ebi.ac.uk/pdbsum/4JRK PDBsum 4JUV http://www.ebi.ac.uk/pdbsum/4JUV PDBsum 4RCB http://www.ebi.ac.uk/pdbsum/4RCB PDBsum 4RCC http://www.ebi.ac.uk/pdbsum/4RCC PDBsum 4V2S http://www.ebi.ac.uk/pdbsum/4V2S PSORT swissprot:HFQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HFQ_ECOLI PSORT-B swissprot:HFQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HFQ_ECOLI PSORT2 swissprot:HFQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HFQ_ECOLI Pfam PF17209 http://pfam.xfam.org/family/PF17209 Phobius swissprot:HFQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HFQ_ECOLI PhylomeDB P0A6X3 http://phylomedb.org/?seqid=P0A6X3 ProteinModelPortal P0A6X3 http://www.proteinmodelportal.org/query/uniprot/P0A6X3 PubMed 10677490 http://www.ncbi.nlm.nih.gov/pubmed/10677490 PubMed 11222598 http://www.ncbi.nlm.nih.gov/pubmed/11222598 PubMed 12853626 http://www.ncbi.nlm.nih.gov/pubmed/12853626 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17158661 http://www.ncbi.nlm.nih.gov/pubmed/17158661 PubMed 18230766 http://www.ncbi.nlm.nih.gov/pubmed/18230766 PubMed 19909729 http://www.ncbi.nlm.nih.gov/pubmed/19909729 PubMed 1999389 http://www.ncbi.nlm.nih.gov/pubmed/1999389 PubMed 2020545 http://www.ncbi.nlm.nih.gov/pubmed/2020545 PubMed 24748661 http://www.ncbi.nlm.nih.gov/pubmed/24748661 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 805130 http://www.ncbi.nlm.nih.gov/pubmed/805130 PubMed 8248183 http://www.ncbi.nlm.nih.gov/pubmed/8248183 PubMed 9245691 http://www.ncbi.nlm.nih.gov/pubmed/9245691 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418593 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418593 RefSeq WP_001051883 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001051883 SMR P0A6X3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6X3 STRING 511145.b4172 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4172&targetmode=cogs STRING COG1923 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1923&targetmode=cogs SUPFAM SSF50182 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50182 TIGRFAMs TIGR02383 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02383 UniProtKB HFQ_ECOLI http://www.uniprot.org/uniprot/HFQ_ECOLI UniProtKB-AC P0A6X3 http://www.uniprot.org/uniprot/P0A6X3 charge swissprot:HFQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HFQ_ECOLI eggNOG COG1923 http://eggnogapi.embl.de/nog_data/html/tree/COG1923 eggNOG ENOG4105KW8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KW8 epestfind swissprot:HFQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HFQ_ECOLI garnier swissprot:HFQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HFQ_ECOLI helixturnhelix swissprot:HFQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HFQ_ECOLI hmoment swissprot:HFQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HFQ_ECOLI iep swissprot:HFQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HFQ_ECOLI inforesidue swissprot:HFQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HFQ_ECOLI octanol swissprot:HFQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HFQ_ECOLI pepcoil swissprot:HFQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HFQ_ECOLI pepdigest swissprot:HFQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HFQ_ECOLI pepinfo swissprot:HFQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HFQ_ECOLI pepnet swissprot:HFQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HFQ_ECOLI pepstats swissprot:HFQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HFQ_ECOLI pepwheel swissprot:HFQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HFQ_ECOLI pepwindow swissprot:HFQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HFQ_ECOLI sigcleave swissprot:HFQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HFQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4259286 274 # CAZy GT51 Glycosyltransferase Family 51 # EcoGene EG12808 mtgA # FUNCTION MTGA_ECOLI Cell wall formation. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0009274 peptidoglycan-based cell wall; IEA:InterPro. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0008955 peptidoglycan glycosyltransferase activity; IDA:EcoCyc. # GO_function GO:0016763 transferase activity, transferring pentosyl groups; IEA:UniProtKB-HAMAP. # GO_process GO:0008360 regulation of cell shape; IEA:UniProtKB-KW. # GO_process GO:0009252 peptidoglycan biosynthetic process; IDA:EcoCyc. # GO_process GO:0043164 Gram-negative-bacterium-type cell wall biogenesis; IDA:EcoCyc. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005618 cell wall # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0071554 cell wall organization or biogenesis # HAMAP MF_00766 Mono_pep_trsgly # INTERACTION MTGA_ECOLI P0AD68 ftsI; NbExp=3; IntAct=EBI-558469, EBI-548564; # IntAct P46022 5 # InterPro IPR001264 Glyco_trans_51 # InterPro IPR011812 Mono_pep_trsgly # InterPro IPR023346 Lysozyme-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01003 Glycosyltransferases # KEGG_Pathway ko00550 Peptidoglycan biosynthesis # Organism MTGA_ECOLI Escherichia coli (strain K12) # PATHWAY MTGA_ECOLI Cell wall biogenesis; peptidoglycan biosynthesis. # PATRIC 32121836 VBIEscCol129921_3302 # PIR B65112 B65112 # Pfam PF00912 Transgly # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MTGA_ECOLI Monofunctional biosynthetic peptidoglycan transglycosylase # RefSeq NP_417675 NC_000913.3 # RefSeq WP_000047091 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=D13188; Type=Frameshift; Positions=38; Evidence={ECO 0000305}; # SIMILARITY Belongs to the glycosyltransferase 51 family. {ECO 0000305}. # SUBCELLULAR LOCATION MTGA_ECOLI Cell membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. # SUPFAM SSF53955 SSF53955 # TIGRFAMs TIGR02070 mono_pep_trsgly # eggNOG COG0744 LUCA # eggNOG ENOG4108VKV Bacteria BLAST swissprot:MTGA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MTGA_ECOLI BioCyc ECOL316407:JW3175-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3175-MONOMER BioCyc EcoCyc:G7668-MONOMER http://biocyc.org/getid?id=EcoCyc:G7668-MONOMER BioCyc MetaCyc:G7668-MONOMER http://biocyc.org/getid?id=MetaCyc:G7668-MONOMER COG COG0744 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0744 DIP DIP-10266N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10266N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.4.2.- http://www.genome.jp/dbget-bin/www_bget?EC:2.4.2.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D13188 http://www.ebi.ac.uk/ena/data/view/D13188 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 2.4.2.- http://enzyme.expasy.org/EC/2.4.2.- EchoBASE EB2659 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2659 EcoGene EG12808 http://www.ecogene.org/geneInfo.php?eg_id=EG12808 EnsemblBacteria AAC76240 http://www.ensemblgenomes.org/id/AAC76240 EnsemblBacteria AAC76240 http://www.ensemblgenomes.org/id/AAC76240 EnsemblBacteria BAE77252 http://www.ensemblgenomes.org/id/BAE77252 EnsemblBacteria BAE77252 http://www.ensemblgenomes.org/id/BAE77252 EnsemblBacteria BAE77252 http://www.ensemblgenomes.org/id/BAE77252 EnsemblBacteria b3208 http://www.ensemblgenomes.org/id/b3208 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0009274 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009274 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008955 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008955 GO_function GO:0016763 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016763 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0009252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009252 GO_process GO:0043164 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043164 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005618 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 GeneID 947728 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947728 HAMAP MF_00766 http://hamap.expasy.org/unirule/MF_00766 HOGENOM HOG000288117 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000288117&db=HOGENOM6 InParanoid P46022 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P46022 IntAct P46022 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P46022* IntEnz 2.4.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.2 InterPro IPR001264 http://www.ebi.ac.uk/interpro/entry/IPR001264 InterPro IPR011812 http://www.ebi.ac.uk/interpro/entry/IPR011812 InterPro IPR023346 http://www.ebi.ac.uk/interpro/entry/IPR023346 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01003 http://www.genome.jp/dbget-bin/www_bget?ko01003 KEGG_Gene ecj:JW3175 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3175 KEGG_Gene eco:b3208 http://www.genome.jp/dbget-bin/www_bget?eco:b3208 KEGG_Orthology KO:K03814 http://www.genome.jp/dbget-bin/www_bget?KO:K03814 KEGG_Pathway ko00550 http://www.genome.jp/kegg-bin/show_pathway?ko00550 MINT MINT-1226871 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1226871 OMA QISAWLS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QISAWLS PSORT swissprot:MTGA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MTGA_ECOLI PSORT-B swissprot:MTGA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MTGA_ECOLI PSORT2 swissprot:MTGA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MTGA_ECOLI Pfam PF00912 http://pfam.xfam.org/family/PF00912 Phobius swissprot:MTGA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MTGA_ECOLI PhylomeDB P46022 http://phylomedb.org/?seqid=P46022 ProteinModelPortal P46022 http://www.proteinmodelportal.org/query/uniprot/P46022 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417675 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417675 RefSeq WP_000047091 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000047091 SMR P46022 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P46022 STRING 511145.b3208 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3208&targetmode=cogs STRING COG0744 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0744&targetmode=cogs SUPFAM SSF53955 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53955 TIGRFAMs TIGR02070 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02070 UniProtKB MTGA_ECOLI http://www.uniprot.org/uniprot/MTGA_ECOLI UniProtKB-AC P46022 http://www.uniprot.org/uniprot/P46022 charge swissprot:MTGA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MTGA_ECOLI eggNOG COG0744 http://eggnogapi.embl.de/nog_data/html/tree/COG0744 eggNOG ENOG4108VKV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108VKV epestfind swissprot:MTGA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MTGA_ECOLI garnier swissprot:MTGA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MTGA_ECOLI helixturnhelix swissprot:MTGA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MTGA_ECOLI hmoment swissprot:MTGA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MTGA_ECOLI iep swissprot:MTGA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MTGA_ECOLI inforesidue swissprot:MTGA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MTGA_ECOLI octanol swissprot:MTGA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MTGA_ECOLI pepcoil swissprot:MTGA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MTGA_ECOLI pepdigest swissprot:MTGA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MTGA_ECOLI pepinfo swissprot:MTGA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MTGA_ECOLI pepnet swissprot:MTGA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MTGA_ECOLI pepstats swissprot:MTGA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MTGA_ECOLI pepwheel swissprot:MTGA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MTGA_ECOLI pepwindow swissprot:MTGA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MTGA_ECOLI sigcleave swissprot:MTGA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MTGA_ECOLI ## Database ID URL or Descriptions # AltName KILR_ECOLI FtsZ inhibitor protein KilR # BioGrid 4260165 127 # EcoGene EG12155 kilR # FUNCTION KILR_ECOLI Causes inhibition of cell division. At high levels of expression, can also abolish the rod shape of the cells. Division inhibition by KilR can be relieved by overexpression of the cell division protein FtsZ. {ECO 0000269|PubMed 8752325}. # GO_process GO:0007049 cell cycle; IEA:UniProtKB-KW. # GO_process GO:0046677 response to antibiotic; IMP:EcoCyc. # GO_process GO:0051301 cell division; IEA:UniProtKB-KW. # GO_process GO:0051782 negative regulation of cell division; IMP:EcoliWiki. # GOslim_process GO:0007049 cell cycle # GOslim_process GO:0008150 biological_process # GOslim_process GO:0051301 cell division # IntAct P38393 12 # MISCELLANEOUS KILR_ECOLI This protein is encoded on Rac prophage. # Organism KILR_ECOLI Escherichia coli (strain K12) # PATRIC 32117984 VBIEscCol129921_1412 # PIR C64885 C64885 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName KILR_ECOLI Killing protein KilR # RefSeq NP_415869 NC_000913.3 # RefSeq WP_000560225 NZ_CP014272.1 # SEQUENCE CAUTION Sequence=AAA32250.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; BLAST swissprot:KILR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:KILR_ECOLI BioCyc ECOL316407:JW1347-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1347-MONOMER BioCyc EcoCyc:EG12155-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12155-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M96749 http://www.ebi.ac.uk/ena/data/view/M96749 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL Z23096 http://www.ebi.ac.uk/ena/data/view/Z23096 EchoBASE EB2075 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2075 EcoGene EG12155 http://www.ecogene.org/geneInfo.php?eg_id=EG12155 EnsemblBacteria AAC74434 http://www.ensemblgenomes.org/id/AAC74434 EnsemblBacteria AAC74434 http://www.ensemblgenomes.org/id/AAC74434 EnsemblBacteria BAA14955 http://www.ensemblgenomes.org/id/BAA14955 EnsemblBacteria BAA14955 http://www.ensemblgenomes.org/id/BAA14955 EnsemblBacteria BAA14955 http://www.ensemblgenomes.org/id/BAA14955 EnsemblBacteria b1352 http://www.ensemblgenomes.org/id/b1352 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GO_process GO:0051782 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051782 GOslim_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GeneID 945921 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945921 HOGENOM HOG000009381 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009381&db=HOGENOM6 IntAct P38393 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P38393* KEGG_Gene ecj:JW1347 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1347 KEGG_Gene eco:b1352 http://www.genome.jp/dbget-bin/www_bget?eco:b1352 OMA MEIIMIA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MEIIMIA PSORT swissprot:KILR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:KILR_ECOLI PSORT-B swissprot:KILR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:KILR_ECOLI PSORT2 swissprot:KILR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:KILR_ECOLI Phobius swissprot:KILR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:KILR_ECOLI ProteinModelPortal P38393 http://www.proteinmodelportal.org/query/uniprot/P38393 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7508908 http://www.ncbi.nlm.nih.gov/pubmed/7508908 PubMed 8752325 http://www.ncbi.nlm.nih.gov/pubmed/8752325 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415869 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415869 RefSeq WP_000560225 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000560225 STRING 511145.b1352 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1352&targetmode=cogs UniProtKB KILR_ECOLI http://www.uniprot.org/uniprot/KILR_ECOLI UniProtKB-AC P38393 http://www.uniprot.org/uniprot/P38393 charge swissprot:KILR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:KILR_ECOLI epestfind swissprot:KILR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:KILR_ECOLI garnier swissprot:KILR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:KILR_ECOLI helixturnhelix swissprot:KILR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:KILR_ECOLI hmoment swissprot:KILR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:KILR_ECOLI iep swissprot:KILR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:KILR_ECOLI inforesidue swissprot:KILR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:KILR_ECOLI octanol swissprot:KILR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:KILR_ECOLI pepcoil swissprot:KILR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:KILR_ECOLI pepdigest swissprot:KILR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:KILR_ECOLI pepinfo swissprot:KILR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:KILR_ECOLI pepnet swissprot:KILR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:KILR_ECOLI pepstats swissprot:KILR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:KILR_ECOLI pepwheel swissprot:KILR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:KILR_ECOLI pepwindow swissprot:KILR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:KILR_ECOLI sigcleave swissprot:KILR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:KILR_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES NAGA_ECOLI Kinetic parameters KM=0.3 mM for N-acetyl-glucosamine 6-phosphate (at 30 degrees Celsius and pH 7.5) {ECO 0000269|PubMed 17567047, ECO 0000269|PubMed 4861885, ECO 0000269|PubMed 9143339}; KM=0.8 mM for N-acetyl-glucosamine 6-phosphate (at 37 degrees Celsius and pH 8.0) {ECO 0000269|PubMed 17567047, ECO 0000269|PubMed 4861885, ECO 0000269|PubMed 9143339}; KM=20 mM for glucosamine 6-phosphate (at 30 degrees Celsius and pH 7.5) {ECO 0000269|PubMed 17567047, ECO 0000269|PubMed 4861885, ECO 0000269|PubMed 9143339}; KM=20 mM for acetate (at 30 degrees Celsius and pH 7.5) {ECO 0000269|PubMed 17567047, ECO 0000269|PubMed 4861885, ECO 0000269|PubMed 9143339}; KM=0.08 mM for N-acetyl-D-glucosamine-6-phosphate (at 30 degrees Celsius and pH 7.5 using Zn-reconstituted form of the enzyme) {ECO 0000269|PubMed 17567047, ECO 0000269|PubMed 4861885, ECO 0000269|PubMed 9143339}; KM=1.24 mM for N-acetyl-D-galactosamine-6-phosphate (at 30 degrees Celsius and pH 7.5 using Zn-reconstituted form of the enzyme) {ECO 0000269|PubMed 17567047, ECO 0000269|PubMed 4861885, ECO 0000269|PubMed 9143339}; Note=kcat is 102 sec(-1) for the deacetylation of N-acetyl-D- glucosamine-6-phosphate by the Zn-enzyme. The Cd-NagA catalyzes the hydrolysis of N-thioacetyl-D-glucosamine-6-phosphate substrate about an order of magnitude better than does the Zn- substituted enzyme. The N-trifluoroacetyl substituted substrate is hydrolyzed 26 times faster than the natural substrate, but the N-formyl substrate is hydrolyzed more slowly by a factor of 5. {ECO 0000269|PubMed 17567047, ECO 0000269|PubMed 4861885, ECO 0000269|PubMed 9143339}; pH dependence Optimum pH is 8.5. {ECO 0000269|PubMed 17567047, ECO 0000269|PubMed 4861885, ECO 0000269|PubMed 9143339}; # BRENDA 3.5.1.25 2026 # BioGrid 4261208 12 # CATALYTIC ACTIVITY NAGA_ECOLI N-acetyl-D-glucosamine 6-phosphate + H(2)O = D-glucosamine 6-phosphate + acetate. {ECO 0000269|PubMed 16630633, ECO 0000269|PubMed 17567047, ECO 0000269|PubMed 17567048, ECO 0000269|PubMed 4861885, ECO 0000269|PubMed 9143339}. # CDD cd00854 NagA # COFACTOR NAGA_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 16630633, ECO 0000269|PubMed 17567047, ECO 0000269|PubMed 17567048}; Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000269|PubMed 16630633, ECO 0000269|PubMed 17567047, ECO 0000269|PubMed 17567048}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 16630633, ECO 0000269|PubMed 17567047, ECO 0000269|PubMed 17567048}; Name=Cd(2+); Xref=ChEBI CHEBI 48775; Evidence={ECO 0000269|PubMed 16630633, ECO 0000269|PubMed 17567047, ECO 0000269|PubMed 17567048}; Name=Fe(2+); Xref=ChEBI CHEBI 29033; Evidence={ECO 0000269|PubMed 16630633, ECO 0000269|PubMed 17567047, ECO 0000269|PubMed 17567048}; Name=Ni(2+); Xref=ChEBI CHEBI 49786; Evidence={ECO 0000269|PubMed 16630633, ECO 0000269|PubMed 17567047, ECO 0000269|PubMed 17567048}; Note=Binds 1 divalent metal cation per subunit. The highest efficient metals are Zn(2+) and Co(2+), followed by Mn(2+), Cd(2+), Fe(2+) and Ni(2+). {ECO 0000269|PubMed 16630633, ECO 0000269|PubMed 17567047, ECO 0000269|PubMed 17567048}; # DISRUPTION PHENOTYPE Synthesizes high levels of glucosamine-6- phosphate deaminase and over half of the amount of glucosamine-6- phosphate synthase compared to wild-type. {ECO:0000269|PubMed 8349539}. # ENZYME REGULATION NAGA_ECOLI Inhibited by high substrate concentration and by products glucosamine 6-phosphate and acetate. Completely inactivated by the treatment with 5,5'-dithio-bis(2-nitrobenzoate) or 2,2'-dithio-pyridine (2-DPDS). Inhibited by 1,10-phenanthroline and EDTA. {ECO 0000269|PubMed 16630633, ECO 0000269|PubMed 17567047, ECO 0000269|PubMed 4861885, ECO 0000269|PubMed 9143339}. # EcoGene EG10632 nagA # FUNCTION NAGA_ECOLI Involved in the first step in the biosynthesis of amino- sugar-nucleotides. Catalyzes the hydrolysis of the N-acetyl group of N-acetylglucosamine-6-phosphate (GlcNAc-6-P) to yield glucosamine 6-phosphate and acetate. In vitro, can also hydrolyze substrate analogs such as N-thioacetyl-D-glucosamine-6-phosphate, N-trifluoroacetyl-D-glucosamine-6-phosphate, N-acetyl-D- glucosamine-6-sulfate, N-acetyl-D-galactosamine-6-phosphate, and N-formyl-D-glucosamine-6-phosphate. {ECO 0000269|PubMed 16630633, ECO 0000269|PubMed 17567047, ECO 0000269|PubMed 17567048, ECO 0000269|PubMed 2190615, ECO 0000269|PubMed 4861885, ECO 0000269|PubMed 9143339}. # GO_function GO:0008270 zinc ion binding; IDA:UniProtKB. # GO_function GO:0008448 N-acetylglucosamine-6-phosphate deacetylase activity; IDA:UniProtKB. # GO_process GO:0005975 carbohydrate metabolic process; IEA:UniProtKB-KW. # GO_process GO:0006046 N-acetylglucosamine catabolic process; IDA:UniProtKB. # GO_process GO:0019262 N-acetylneuraminate catabolic process; IMP:EcoCyc. # GO_process GO:0051289 protein homotetramerization; IDA:UniProtKB. # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 2.30.40.10 -; 2. # INDUCTION By N-acetylglucosamine. Induced by low extracellular levels of magnesium via the PhoQ/PhoP two-component regulatory system. {ECO:0000269|PubMed 12813061}. # IntAct P0AF18 5 # InterPro IPR003764 GlcNAc_6-P_deAcase # InterPro IPR006680 Amidohydro-rel # InterPro IPR011059 Metal-dep_hydrolase_composite # InterPro IPR032466 Metal_Hydrolase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00520 Amino sugar and nucleotide sugar metabolism # Organism NAGA_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 4/5. {ECO 0000305|PubMed:2190615}. # PATRIC 32116539 VBIEscCol129921_0702 # PDB 1YMY X-ray; 2.60 A; A/B=1-382 # PDB 1YRR X-ray; 2.00 A; A/B=1-382 # PDB 2P50 X-ray; 2.20 A; A/B/C/D=1-382 # PDB 2P53 X-ray; 2.10 A; A/B=1-382 # PIR A37018 A37018 # PIRSF PIRSF038994 NagA # Pfam PF01979 Amidohydro_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName N-acetylglucosamine-6-phosphate deacetylase {ECO:0000303|PubMed 2190615} # RefSeq NP_415203 NC_000913.3 # RefSeq WP_000271153 NZ_LN832404.1 # SIMILARITY Belongs to the NagA family. {ECO 0000305}. # SUBUNIT NAGA_ECOLI Homotetramer. {ECO 0000269|PubMed 16630633, ECO 0000269|PubMed 17567047, ECO 0000269|PubMed 17567048, ECO 0000269|PubMed 9143339}. # SUPFAM SSF51338 SSF51338 # SUPFAM SSF51556 SSF51556 # TIGRFAMs TIGR00221 nagA # UniPathway UPA00629 UER00683 # eggNOG COG1820 LUCA # eggNOG ENOG4105CE4 Bacteria BLAST swissprot:NAGA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NAGA_ECOLI BioCyc ECOL316407:JW0663-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0663-MONOMER BioCyc EcoCyc:NAG6PDEACET-MONOMER http://biocyc.org/getid?id=EcoCyc:NAG6PDEACET-MONOMER BioCyc MetaCyc:NAG6PDEACET-MONOMER http://biocyc.org/getid?id=MetaCyc:NAG6PDEACET-MONOMER COG COG1820 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1820 DIP DIP-10297N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10297N DOI 10.1006/abbi.1997.9780 http://dx.doi.org/10.1006/abbi.1997.9780 DOI 10.1016/j.jmb.2006.03.024 http://dx.doi.org/10.1016/j.jmb.2006.03.024 DOI 10.1021/bi700543x http://dx.doi.org/10.1021/bi700543x DOI 10.1021/bi700544c http://dx.doi.org/10.1021/bi700544c DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj1050121 http://dx.doi.org/10.1042/bj1050121 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1107/S0907444900003668 http://dx.doi.org/10.1107/S0907444900003668 DOI 10.1111/j.1365-2958.1989.tb00197.x http://dx.doi.org/10.1111/j.1365-2958.1989.tb00197.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.185.13.3696-3702.2003 http://dx.doi.org/10.1128/JB.185.13.3696-3702.2003 EC_number EC:3.5.1.25 {ECO:0000269|PubMed:16630633, ECO:0000269|PubMed:17567047, ECO:0000269|PubMed:17567048, ECO:0000269|PubMed:4861885, ECO:0000269|PubMed:9143339} http://www.genome.jp/dbget-bin/www_bget?EC:3.5.1.25 {ECO:0000269|PubMed:16630633, ECO:0000269|PubMed:17567047, ECO:0000269|PubMed:17567048, ECO:0000269|PubMed:4861885, ECO:0000269|PubMed:9143339} EMBL AF052007 http://www.ebi.ac.uk/ena/data/view/AF052007 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X14135 http://www.ebi.ac.uk/ena/data/view/X14135 ENZYME 3.5.1.25 {ECO:0000269|PubMed:16630633, ECO:0000269|PubMed:17567047, ECO:0000269|PubMed:17567048, ECO:0000269|PubMed:4861885, ECO:0000269|PubMed:9143339} http://enzyme.expasy.org/EC/3.5.1.25 {ECO:0000269|PubMed:16630633, ECO:0000269|PubMed:17567047, ECO:0000269|PubMed:17567048, ECO:0000269|PubMed:4861885, ECO:0000269|PubMed:9143339} EchoBASE EB0626 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0626 EcoGene EG10632 http://www.ecogene.org/geneInfo.php?eg_id=EG10632 EnsemblBacteria AAC73771 http://www.ensemblgenomes.org/id/AAC73771 EnsemblBacteria AAC73771 http://www.ensemblgenomes.org/id/AAC73771 EnsemblBacteria BAA35320 http://www.ensemblgenomes.org/id/BAA35320 EnsemblBacteria BAA35320 http://www.ensemblgenomes.org/id/BAA35320 EnsemblBacteria BAA35320 http://www.ensemblgenomes.org/id/BAA35320 EnsemblBacteria b0677 http://www.ensemblgenomes.org/id/b0677 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0008448 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008448 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GO_process GO:0006046 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006046 GO_process GO:0019262 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019262 GO_process GO:0051289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051289 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 2.30.40.10 http://www.cathdb.info/version/latest/superfamily/2.30.40.10 GeneID 945289 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945289 HOGENOM HOG000275008 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275008&db=HOGENOM6 InParanoid P0AF18 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AF18 IntAct P0AF18 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AF18* IntEnz 3.5.1.25 {ECO:0000269|PubMed:16630633, ECO:0000269|PubMed:17567047, ECO:0000269|PubMed:17567048, ECO:0000269|PubMed:4861885, ECO:0000269|PubMed:9143339} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.1.25 {ECO:0000269|PubMed:16630633, ECO:0000269|PubMed:17567047, ECO:0000269|PubMed:17567048, ECO:0000269|PubMed:4861885, ECO:0000269|PubMed:9143339} InterPro IPR003764 http://www.ebi.ac.uk/interpro/entry/IPR003764 InterPro IPR006680 http://www.ebi.ac.uk/interpro/entry/IPR006680 InterPro IPR011059 http://www.ebi.ac.uk/interpro/entry/IPR011059 InterPro IPR032466 http://www.ebi.ac.uk/interpro/entry/IPR032466 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0663 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0663 KEGG_Gene eco:b0677 http://www.genome.jp/dbget-bin/www_bget?eco:b0677 KEGG_Orthology KO:K01443 http://www.genome.jp/dbget-bin/www_bget?KO:K01443 KEGG_Pathway ko00520 http://www.genome.jp/kegg-bin/show_pathway?ko00520 KEGG_Reaction rn:R02059 http://www.genome.jp/dbget-bin/www_bget?rn:R02059 OMA PAGANMD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PAGANMD PDB 1YMY http://www.ebi.ac.uk/pdbe-srv/view/entry/1YMY PDB 1YRR http://www.ebi.ac.uk/pdbe-srv/view/entry/1YRR PDB 2P50 http://www.ebi.ac.uk/pdbe-srv/view/entry/2P50 PDB 2P53 http://www.ebi.ac.uk/pdbe-srv/view/entry/2P53 PDBsum 1YMY http://www.ebi.ac.uk/pdbsum/1YMY PDBsum 1YRR http://www.ebi.ac.uk/pdbsum/1YRR PDBsum 2P50 http://www.ebi.ac.uk/pdbsum/2P50 PDBsum 2P53 http://www.ebi.ac.uk/pdbsum/2P53 PSORT swissprot:NAGA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NAGA_ECOLI PSORT-B swissprot:NAGA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NAGA_ECOLI PSORT2 swissprot:NAGA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NAGA_ECOLI Pfam PF01979 http://pfam.xfam.org/family/PF01979 Phobius swissprot:NAGA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NAGA_ECOLI PhylomeDB P0AF18 http://phylomedb.org/?seqid=P0AF18 ProteinModelPortal P0AF18 http://www.proteinmodelportal.org/query/uniprot/P0AF18 PubMed 10771446 http://www.ncbi.nlm.nih.gov/pubmed/10771446 PubMed 12813061 http://www.ncbi.nlm.nih.gov/pubmed/12813061 PubMed 16630633 http://www.ncbi.nlm.nih.gov/pubmed/16630633 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17567047 http://www.ncbi.nlm.nih.gov/pubmed/17567047 PubMed 17567048 http://www.ncbi.nlm.nih.gov/pubmed/17567048 PubMed 2190615 http://www.ncbi.nlm.nih.gov/pubmed/2190615 PubMed 2668691 http://www.ncbi.nlm.nih.gov/pubmed/2668691 PubMed 4861885 http://www.ncbi.nlm.nih.gov/pubmed/4861885 PubMed 8349539 http://www.ncbi.nlm.nih.gov/pubmed/8349539 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9143339 http://www.ncbi.nlm.nih.gov/pubmed/9143339 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415203 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415203 RefSeq WP_000271153 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000271153 SMR P0AF18 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AF18 STRING 511145.b0677 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0677&targetmode=cogs STRING COG1820 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1820&targetmode=cogs SUPFAM SSF51338 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51338 SUPFAM SSF51556 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51556 TIGRFAMs TIGR00221 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00221 UniProtKB NAGA_ECOLI http://www.uniprot.org/uniprot/NAGA_ECOLI UniProtKB-AC P0AF18 http://www.uniprot.org/uniprot/P0AF18 charge swissprot:NAGA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NAGA_ECOLI eggNOG COG1820 http://eggnogapi.embl.de/nog_data/html/tree/COG1820 eggNOG ENOG4105CE4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CE4 epestfind swissprot:NAGA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NAGA_ECOLI garnier swissprot:NAGA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NAGA_ECOLI helixturnhelix swissprot:NAGA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NAGA_ECOLI hmoment swissprot:NAGA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NAGA_ECOLI iep swissprot:NAGA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NAGA_ECOLI inforesidue swissprot:NAGA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NAGA_ECOLI octanol swissprot:NAGA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NAGA_ECOLI pepcoil swissprot:NAGA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NAGA_ECOLI pepdigest swissprot:NAGA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NAGA_ECOLI pepinfo swissprot:NAGA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NAGA_ECOLI pepnet swissprot:NAGA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NAGA_ECOLI pepstats swissprot:NAGA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NAGA_ECOLI pepwheel swissprot:NAGA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NAGA_ECOLI pepwindow swissprot:NAGA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NAGA_ECOLI sigcleave swissprot:NAGA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NAGA_ECOLI ## Database ID URL or Descriptions # AltName Aminopeptidase B {ECO:0000255|HAMAP-Rule MF_00504} # BioGrid 4261583 5 # CATALYTIC ACTIVITY Release of an N-terminal amino acid, Xaa, from a peptide or arylamide. Xaa is preferably Glu or Asp but may be other amino acids, including Leu, Met, His, Cys and Gln. {ECO:0000255|HAMAP-Rule MF_00504}. # CDD cd00433 Peptidase_M17 # COFACTOR PEPB_ECOLI Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000255|HAMAP-Rule MF_00504}; Note=Binds 2 manganese ions per subunit. {ECO 0000255|HAMAP- Rule MF_00504}; # DISRUPTION PHENOTYPE A quadruple peptidase disruption (pepA, pepB, pepD and pepN) does not grow in M9 minimal medium, grows better when supplemented with casamino acids (PubMed:20067529). {ECO 0000269|PubMed:20067529}. # EcoGene EG12310 pepB # FUNCTION PEPB_ECOLI Probably plays an important role in intracellular peptide degradation (PubMed 20067529). {ECO 0000255|HAMAP- Rule MF_00504, ECO 0000305|PubMed 20067529}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0004177 aminopeptidase activity; IDA:EcoCyc. # GO_function GO:0008235 metalloexopeptidase activity; IEA:InterPro. # GO_function GO:0030145 manganese ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0006508 proteolysis; IDA:EcoCyc. # GO_process GO:0043171 peptide catabolic process; IGI:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # HAMAP MF_00504 Aminopeptidase_M17 # IntAct P37095 16 # InterPro IPR000819 Peptidase_M17_C # InterPro IPR008330 Pept_M17_PepB # InterPro IPR011356 Leucine_aapep/pepB # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # KEGG_Pathway ko00480 Glutathione metabolism # Organism PEPB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11963 PTHR11963 # PATRIC 32120441 VBIEscCol129921_2623 # PIR B65029 B65029 # PIRSF PIRSF036388 Ctsl_amnpptdse_B # PRINTS PR00481 LAMNOPPTDASE # PROSITE PS00631 CYTOSOL_AP # Pfam PF00883 Peptidase_M17 # Pfam PF12404 DUF3663 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Peptidase B {ECO:0000255|HAMAP-Rule MF_00504} # RefSeq NP_417018 NC_000913.3 # RefSeq WP_000133592 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase M17 family. {ECO:0000255|HAMAP-Rule MF_00504}. # SUBCELLULAR LOCATION PEPB_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00504}. # SUBUNIT Homohexamer. {ECO:0000255|HAMAP-Rule MF_00504}. # eggNOG COG0260 LUCA # eggNOG ENOG4105BZ6 Bacteria BLAST swissprot:PEPB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PEPB_ECOLI BioCyc ECOL316407:JW2507-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2507-MONOMER BioCyc EcoCyc:EG12310-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12310-MONOMER BioCyc MetaCyc:EG12310-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12310-MONOMER COG COG0260 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0260 DIP DIP-10455N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10455N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1111/j.1574-6968.2009.01879.x http://dx.doi.org/10.1111/j.1574-6968.2009.01879.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.11.23 {ECO:0000255|HAMAP-Rule:MF_00504} http://www.genome.jp/dbget-bin/www_bget?EC:3.4.11.23 {ECO:0000255|HAMAP-Rule:MF_00504} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D84499 http://www.ebi.ac.uk/ena/data/view/D84499 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U01827 http://www.ebi.ac.uk/ena/data/view/U01827 ENZYME 3.4.11.23 {ECO:0000255|HAMAP-Rule:MF_00504} http://enzyme.expasy.org/EC/3.4.11.23 {ECO:0000255|HAMAP-Rule:MF_00504} EchoBASE EB2216 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2216 EcoGene EG12310 http://www.ecogene.org/geneInfo.php?eg_id=EG12310 EnsemblBacteria AAC75576 http://www.ensemblgenomes.org/id/AAC75576 EnsemblBacteria AAC75576 http://www.ensemblgenomes.org/id/AAC75576 EnsemblBacteria BAA16413 http://www.ensemblgenomes.org/id/BAA16413 EnsemblBacteria BAA16413 http://www.ensemblgenomes.org/id/BAA16413 EnsemblBacteria BAA16413 http://www.ensemblgenomes.org/id/BAA16413 EnsemblBacteria b2523 http://www.ensemblgenomes.org/id/b2523 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004177 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004177 GO_function GO:0008235 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008235 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0006508 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006508 GO_process GO:0043171 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043171 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 948766 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948766 HAMAP MF_00504 http://hamap.expasy.org/unirule/MF_00504 HOGENOM HOG000243130 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000243130&db=HOGENOM6 InParanoid P37095 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37095 IntAct P37095 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37095* IntEnz 3.4.11.23 {ECO:0000255|HAMAP-Rule:MF_00504} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.11.23 {ECO:0000255|HAMAP-Rule:MF_00504} InterPro IPR000819 http://www.ebi.ac.uk/interpro/entry/IPR000819 InterPro IPR008330 http://www.ebi.ac.uk/interpro/entry/IPR008330 InterPro IPR011356 http://www.ebi.ac.uk/interpro/entry/IPR011356 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW2507 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2507 KEGG_Gene eco:b2523 http://www.genome.jp/dbget-bin/www_bget?eco:b2523 KEGG_Orthology KO:K07751 http://www.genome.jp/dbget-bin/www_bget?KO:K07751 KEGG_Pathway ko00480 http://www.genome.jp/kegg-bin/show_pathway?ko00480 KEGG_Reaction rn:R00899 http://www.genome.jp/dbget-bin/www_bget?rn:R00899 KEGG_Reaction rn:R04951 http://www.genome.jp/dbget-bin/www_bget?rn:R04951 MINT MINT-1236207 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1236207 OMA LARIECG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LARIECG PANTHER PTHR11963 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11963 PRINTS PR00481 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00481 PROSITE PS00631 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00631 PSORT swissprot:PEPB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PEPB_ECOLI PSORT-B swissprot:PEPB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PEPB_ECOLI PSORT2 swissprot:PEPB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PEPB_ECOLI Pfam PF00883 http://pfam.xfam.org/family/PF00883 Pfam PF12404 http://pfam.xfam.org/family/PF12404 Phobius swissprot:PEPB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PEPB_ECOLI PhylomeDB P37095 http://phylomedb.org/?seqid=P37095 ProteinModelPortal P37095 http://www.proteinmodelportal.org/query/uniprot/P37095 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20067529 http://www.ncbi.nlm.nih.gov/pubmed/20067529 PubMed 8300516 http://www.ncbi.nlm.nih.gov/pubmed/8300516 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417018 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417018 RefSeq WP_000133592 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000133592 SMR P37095 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37095 STRING 511145.b2523 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2523&targetmode=cogs STRING COG0260 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0260&targetmode=cogs UniProtKB PEPB_ECOLI http://www.uniprot.org/uniprot/PEPB_ECOLI UniProtKB-AC P37095 http://www.uniprot.org/uniprot/P37095 charge swissprot:PEPB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PEPB_ECOLI eggNOG COG0260 http://eggnogapi.embl.de/nog_data/html/tree/COG0260 eggNOG ENOG4105BZ6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZ6 epestfind swissprot:PEPB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PEPB_ECOLI garnier swissprot:PEPB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PEPB_ECOLI helixturnhelix swissprot:PEPB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PEPB_ECOLI hmoment swissprot:PEPB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PEPB_ECOLI iep swissprot:PEPB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PEPB_ECOLI inforesidue swissprot:PEPB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PEPB_ECOLI octanol swissprot:PEPB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PEPB_ECOLI pepcoil swissprot:PEPB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PEPB_ECOLI pepdigest swissprot:PEPB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PEPB_ECOLI pepinfo swissprot:PEPB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PEPB_ECOLI pepnet swissprot:PEPB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PEPB_ECOLI pepstats swissprot:PEPB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PEPB_ECOLI pepwheel swissprot:PEPB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PEPB_ECOLI pepwindow swissprot:PEPB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PEPB_ECOLI sigcleave swissprot:PEPB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PEPB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260240 238 # CDD cd04458 CSP_CDS # EcoGene EG13877 cspI # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0009409 response to cold; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # IntAct P0A986 17 # InterPro IPR002059 CSP_DNA-bd # InterPro IPR011129 Cold_shock_prot # InterPro IPR012156 Cold_shock_CspA # InterPro IPR012340 NA-bd_OB-fold # InterPro IPR019844 Cold-shock_CS # KEGG_Brite ko03000 Transcription factors # Organism CSPI_ECOLI Escherichia coli (strain K12) # PATRIC 32118406 VBIEscCol129921_1623 # PIR C64910 C64910 # PIRSF PIRSF002599 Cold_shock_A # PRINTS PR00050 COLDSHOCK # PROSITE PS00352 COLD_SHOCK # Pfam PF00313 CSD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CSPI_ECOLI Cold shock-like protein CspI # RefSeq NP_416070 NC_000913.3 # RefSeq WP_000066495 NZ_LN832404.1 # SIMILARITY Contains 1 CSD (cold-shock) domain. {ECO 0000305}. # SMART SM00357 CSP # SUBCELLULAR LOCATION CSPI_ECOLI Cytoplasm {ECO 0000250}. # SUPFAM SSF50249 SSF50249 # eggNOG COG1278 LUCA # eggNOG ENOG4105VEQ Bacteria BLAST swissprot:CSPI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CSPI_ECOLI BioCyc ECOL316407:JW1544-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1544-MONOMER BioCyc EcoCyc:G6825-MONOMER http://biocyc.org/getid?id=EcoCyc:G6825-MONOMER COG COG1278 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1278 DIP DIP-48195N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48195N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3636 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3636 EcoGene EG13877 http://www.ecogene.org/geneInfo.php?eg_id=EG13877 EnsemblBacteria AAC74625 http://www.ensemblgenomes.org/id/AAC74625 EnsemblBacteria AAC74625 http://www.ensemblgenomes.org/id/AAC74625 EnsemblBacteria BAA15254 http://www.ensemblgenomes.org/id/BAA15254 EnsemblBacteria BAA15254 http://www.ensemblgenomes.org/id/BAA15254 EnsemblBacteria BAA15254 http://www.ensemblgenomes.org/id/BAA15254 EnsemblBacteria b1552 http://www.ensemblgenomes.org/id/b1552 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0009409 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009409 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 946099 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946099 HOGENOM HOG000070674 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000070674&db=HOGENOM6 InParanoid P0A986 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A986 IntAct P0A986 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A986* InterPro IPR002059 http://www.ebi.ac.uk/interpro/entry/IPR002059 InterPro IPR011129 http://www.ebi.ac.uk/interpro/entry/IPR011129 InterPro IPR012156 http://www.ebi.ac.uk/interpro/entry/IPR012156 InterPro IPR012340 http://www.ebi.ac.uk/interpro/entry/IPR012340 InterPro IPR019844 http://www.ebi.ac.uk/interpro/entry/IPR019844 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW1544 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1544 KEGG_Gene eco:b1552 http://www.genome.jp/dbget-bin/www_bget?eco:b1552 KEGG_Orthology KO:K03704 http://www.genome.jp/dbget-bin/www_bget?KO:K03704 MINT MINT-1309031 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1309031 OMA EVKNGPK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EVKNGPK PRINTS PR00050 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00050 PROSITE PS00352 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00352 PSORT swissprot:CSPI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CSPI_ECOLI PSORT-B swissprot:CSPI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CSPI_ECOLI PSORT2 swissprot:CSPI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CSPI_ECOLI Pfam PF00313 http://pfam.xfam.org/family/PF00313 Phobius swissprot:CSPI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CSPI_ECOLI PhylomeDB P0A986 http://phylomedb.org/?seqid=P0A986 ProteinModelPortal P0A986 http://www.proteinmodelportal.org/query/uniprot/P0A986 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416070 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416070 RefSeq WP_000066495 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000066495 SMART SM00357 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00357 SMR P0A986 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A986 STRING 511145.b1552 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1552&targetmode=cogs STRING COG1278 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1278&targetmode=cogs SUPFAM SSF50249 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50249 UniProtKB CSPI_ECOLI http://www.uniprot.org/uniprot/CSPI_ECOLI UniProtKB-AC P0A986 http://www.uniprot.org/uniprot/P0A986 charge swissprot:CSPI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CSPI_ECOLI eggNOG COG1278 http://eggnogapi.embl.de/nog_data/html/tree/COG1278 eggNOG ENOG4105VEQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VEQ epestfind swissprot:CSPI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CSPI_ECOLI garnier swissprot:CSPI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CSPI_ECOLI helixturnhelix swissprot:CSPI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CSPI_ECOLI hmoment swissprot:CSPI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CSPI_ECOLI iep swissprot:CSPI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CSPI_ECOLI inforesidue swissprot:CSPI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CSPI_ECOLI octanol swissprot:CSPI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CSPI_ECOLI pepcoil swissprot:CSPI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CSPI_ECOLI pepdigest swissprot:CSPI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CSPI_ECOLI pepinfo swissprot:CSPI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CSPI_ECOLI pepnet swissprot:CSPI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CSPI_ECOLI pepstats swissprot:CSPI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CSPI_ECOLI pepwheel swissprot:CSPI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CSPI_ECOLI pepwindow swissprot:CSPI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CSPI_ECOLI sigcleave swissprot:CSPI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CSPI_ECOLI ## Database ID URL or Descriptions # AltName ATP synthase F(0) sector subunit b {ECO:0000255|HAMAP-Rule MF_01398} # AltName ATPase subunit I {ECO:0000255|HAMAP-Rule MF_01398} # AltName F-type ATPase subunit b {ECO:0000255|HAMAP-Rule MF_01398} # EcoGene EG10103 atpF # FUNCTION ATPF_ECOLI Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). {ECO 0000255|HAMAP- Rule MF_01398}. # FUNCTION ATPF_ECOLI F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. {ECO 0000255|HAMAP-Rule MF_01398}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_component GO:0031225 anchored component of membrane; IDA:EcoliWiki. # GO_component GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o); IMP:EcoliWiki. # GO_function GO:0046933 proton-transporting ATP synthase activity, rotational mechanism; IMP:EcoCyc. # GO_function GO:0046961 proton-transporting ATPase activity, rotational mechanism; IMP:EcoCyc. # GO_process GO:0015986 ATP synthesis coupled proton transport; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0055085 transmembrane transport # Gene3D 1.20.5.620 -; 1. # HAMAP MF_01398 ATP_synth_b_bprime # IntAct P0ABA0 2 # InterPro IPR002146 ATP_synth_b/b'su_bac/chlpt # InterPro IPR005864 ATP_synth_F0_bsu_bac # InterPro IPR028987 ATP_synth_B-like_membr # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko00194 Photosynthesis proteins # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00190 Oxidative phosphorylation # KEGG_Pathway ko00195 Photosynthesis # Organism ATPF_ECOLI Escherichia coli (strain K12) # PATRIC 32122969 VBIEscCol129921_3860 # PDB 1B9U NMR; -; A=1-34 # PDB 1L2P X-ray; 1.55 A; A=62-122 # PDB 2KHK NMR; -; A=30-82 # PIR D93732 LWECB # Pfam PF00430 ATP-synt_B # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ATP synthase subunit b {ECO:0000255|HAMAP-Rule MF_01398} # RefSeq NP_418192 NC_000913.3 # RefSeq WP_001052219 NZ_LN832404.1 # SIMILARITY Belongs to the ATPase B chain family. {ECO:0000255|HAMAP-Rule MF_01398}. # SUBCELLULAR LOCATION ATPF_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01398}; Single-pass membrane protein {ECO 0000255|HAMAP- Rule MF_01398}. # SUBUNIT ATPF_ECOLI F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains. {ECO 0000255|HAMAP-Rule MF_01398}. # SUPFAM SSF81573 SSF81573 # TCDB 3.A.2.1 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily # TIGRFAMs TIGR01144 ATP_synt_b # eggNOG COG0711 LUCA # eggNOG ENOG4107Z6K Bacteria BLAST swissprot:ATPF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ATPF_ECOLI BioCyc ECOL316407:JW3714-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3714-MONOMER BioCyc EcoCyc:ATPF-MONOMER http://biocyc.org/getid?id=EcoCyc:ATPF-MONOMER BioCyc MetaCyc:ATPF-MONOMER http://biocyc.org/getid?id=MetaCyc:ATPF-MONOMER COG COG0711 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0711 DIP DIP-35994N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35994N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1007/BF00271191 http://dx.doi.org/10.1007/BF00271191 DOI 10.1016/0006-291X(81)90495-2 http://dx.doi.org/10.1016/0006-291X(81)90495-2 DOI 10.1016/0006-291X(81)91504-7 http://dx.doi.org/10.1016/0006-291X(81)91504-7 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2240799 http://dx.doi.org/10.1042/bj2240799 DOI 10.1074/jbc.274.22.15598 http://dx.doi.org/10.1074/jbc.274.22.15598 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1093/nar/9.16.3919 http://dx.doi.org/10.1093/nar/9.16.3919 DOI 10.1111/j.1749-6632.1982.tb25731.x http://dx.doi.org/10.1111/j.1749-6632.1982.tb25731.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01594 http://www.ebi.ac.uk/ena/data/view/J01594 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M10422 http://www.ebi.ac.uk/ena/data/view/M10422 EMBL M12212 http://www.ebi.ac.uk/ena/data/view/M12212 EMBL M25464 http://www.ebi.ac.uk/ena/data/view/M25464 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00264 http://www.ebi.ac.uk/ena/data/view/V00264 EMBL V00266 http://www.ebi.ac.uk/ena/data/view/V00266 EMBL V00310 http://www.ebi.ac.uk/ena/data/view/V00310 EMBL X01631 http://www.ebi.ac.uk/ena/data/view/X01631 EchoBASE EB0101 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0101 EcoGene EG10103 http://www.ecogene.org/geneInfo.php?eg_id=EG10103 EnsemblBacteria AAC76759 http://www.ensemblgenomes.org/id/AAC76759 EnsemblBacteria AAC76759 http://www.ensemblgenomes.org/id/AAC76759 EnsemblBacteria BAE77552 http://www.ensemblgenomes.org/id/BAE77552 EnsemblBacteria BAE77552 http://www.ensemblgenomes.org/id/BAE77552 EnsemblBacteria BAE77552 http://www.ensemblgenomes.org/id/BAE77552 EnsemblBacteria b3736 http://www.ensemblgenomes.org/id/b3736 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0031225 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031225 GO_component GO:0045263 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045263 GO_function GO:0046933 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046933 GO_function GO:0046961 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046961 GO_process GO:0015986 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015986 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 1.20.5.620 http://www.cathdb.info/version/latest/superfamily/1.20.5.620 GeneID 948247 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948247 HAMAP MF_01398 http://hamap.expasy.org/unirule/MF_01398 HOGENOM HOG000015378 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000015378&db=HOGENOM6 InParanoid P0ABA0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABA0 IntAct P0ABA0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABA0* InterPro IPR002146 http://www.ebi.ac.uk/interpro/entry/IPR002146 InterPro IPR005864 http://www.ebi.ac.uk/interpro/entry/IPR005864 InterPro IPR028987 http://www.ebi.ac.uk/interpro/entry/IPR028987 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko00194 http://www.genome.jp/dbget-bin/www_bget?ko00194 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3714 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3714 KEGG_Gene eco:b3736 http://www.genome.jp/dbget-bin/www_bget?eco:b3736 KEGG_Orthology KO:K02109 http://www.genome.jp/dbget-bin/www_bget?KO:K02109 KEGG_Pathway ko00190 http://www.genome.jp/kegg-bin/show_pathway?ko00190 KEGG_Pathway ko00195 http://www.genome.jp/kegg-bin/show_pathway?ko00195 OMA SMIQDLS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SMIQDLS PDB 1B9U http://www.ebi.ac.uk/pdbe-srv/view/entry/1B9U PDB 1L2P http://www.ebi.ac.uk/pdbe-srv/view/entry/1L2P PDB 2KHK http://www.ebi.ac.uk/pdbe-srv/view/entry/2KHK PDBsum 1B9U http://www.ebi.ac.uk/pdbsum/1B9U PDBsum 1L2P http://www.ebi.ac.uk/pdbsum/1L2P PDBsum 2KHK http://www.ebi.ac.uk/pdbsum/2KHK PSORT swissprot:ATPF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ATPF_ECOLI PSORT-B swissprot:ATPF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ATPF_ECOLI PSORT2 swissprot:ATPF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ATPF_ECOLI Pfam PF00430 http://pfam.xfam.org/family/PF00430 Phobius swissprot:ATPF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ATPF_ECOLI PhylomeDB P0ABA0 http://phylomedb.org/?seqid=P0ABA0 ProteinModelPortal P0ABA0 http://www.proteinmodelportal.org/query/uniprot/P0ABA0 PubMed 10336456 http://www.ncbi.nlm.nih.gov/pubmed/10336456 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1682301 http://www.ncbi.nlm.nih.gov/pubmed/1682301 PubMed 2861200 http://www.ncbi.nlm.nih.gov/pubmed/2861200 PubMed 6272190 http://www.ncbi.nlm.nih.gov/pubmed/6272190 PubMed 6277311 http://www.ncbi.nlm.nih.gov/pubmed/6277311 PubMed 6278247 http://www.ncbi.nlm.nih.gov/pubmed/6278247 PubMed 6301339 http://www.ncbi.nlm.nih.gov/pubmed/6301339 PubMed 6395859 http://www.ncbi.nlm.nih.gov/pubmed/6395859 PubMed 6458296 http://www.ncbi.nlm.nih.gov/pubmed/6458296 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418192 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418192 RefSeq WP_001052219 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001052219 SMR P0ABA0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABA0 STRING 511145.b3736 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3736&targetmode=cogs STRING COG0711 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0711&targetmode=cogs SUPFAM SSF81573 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81573 SWISS-2DPAGE P0ABA0 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0ABA0 TCDB 3.A.2.1 http://www.tcdb.org/search/result.php?tc=3.A.2.1 TIGRFAMs TIGR01144 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01144 UniProtKB ATPF_ECOLI http://www.uniprot.org/uniprot/ATPF_ECOLI UniProtKB-AC P0ABA0 http://www.uniprot.org/uniprot/P0ABA0 charge swissprot:ATPF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ATPF_ECOLI eggNOG COG0711 http://eggnogapi.embl.de/nog_data/html/tree/COG0711 eggNOG ENOG4107Z6K http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107Z6K epestfind swissprot:ATPF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ATPF_ECOLI garnier swissprot:ATPF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ATPF_ECOLI helixturnhelix swissprot:ATPF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ATPF_ECOLI hmoment swissprot:ATPF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ATPF_ECOLI iep swissprot:ATPF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ATPF_ECOLI inforesidue swissprot:ATPF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ATPF_ECOLI octanol swissprot:ATPF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ATPF_ECOLI pepcoil swissprot:ATPF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ATPF_ECOLI pepdigest swissprot:ATPF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ATPF_ECOLI pepinfo swissprot:ATPF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ATPF_ECOLI pepnet swissprot:ATPF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ATPF_ECOLI pepstats swissprot:ATPF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ATPF_ECOLI pepwheel swissprot:ATPF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ATPF_ECOLI pepwindow swissprot:ATPF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ATPF_ECOLI sigcleave swissprot:ATPF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ATPF_ECOLI ## Database ID URL or Descriptions # DrugBank DB00254 Doxycycline # DrugBank DB00256 Lymecycline # DrugBank DB00453 Clomocycline # DrugBank DB00595 Oxytetracycline # DrugBank DB00618 Demeclocycline # DrugBank DB01017 Minocycline # EcoGene EG10903 rpsD # FUNCTION RS4_ECOLI Also functions as a rho-dependent antiterminator of rRNA transcription, increasing the synthesis of rRNA under conditions of excess protein, allowing a more rapid return to homeostasis. Binds directly to RNA polymerase. # FUNCTION RS4_ECOLI One of two assembly initiator proteins for the 30S subunit, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. # FUNCTION RS4_ECOLI Plays a role in mRNA unwinding by the ribosome, possibly by forming part of a processivity clamp. # FUNCTION RS4_ECOLI Protein S4 is also a translational repressor protein, it controls the translation of the alpha-operon (which codes for S13, S11, S4, RNA polymerase alpha subunit, and L17) by binding to its mRNA. # FUNCTION RS4_ECOLI With S5 and S12 plays an important role in translational accuracy; many suppressors of streptomycin-dependent mutants of protein S12 are found in this protein, some but not all of which decrease translational accuracy (ram, ribosomal ambiguity mutations). # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0022627 cytosolic small ribosomal subunit; IDA:EcoCyc. # GO_function GO:0000900 translation repressor activity, nucleic acid binding; IMP:EcoCyc. # GO_function GO:0003735 structural constituent of ribosome; IBA:GO_Central. # GO_function GO:0019843 rRNA binding; IDA:EcoliWiki. # GO_function GO:0048027 mRNA 5'-UTR binding; IDA:EcoCyc. # GO_process GO:0006353 DNA-templated transcription, termination; IEA:UniProtKB-KW. # GO_process GO:0031564 transcription antitermination; IDA:EcoCyc. # GO_process GO:0045903 positive regulation of translational fidelity; IBA:GO_Central. # GO_process GO:0045947 negative regulation of translational initiation; IDA:EcoCyc. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GO_process GO:1990145 maintenance of translational fidelity; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003729 mRNA binding # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_function GO:0019843 rRNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.1050.10 -; 1. # Gene3D 3.10.290.10 -; 1. # HAMAP MF_01306_B Ribosomal_S4_B # IntAct P0A7V8 214 # InterPro IPR001912 Ribosomal_S4/S9_N # InterPro IPR002942 S4_RNA-bd # InterPro IPR005709 Ribosomal_S4_bac-type # InterPro IPR018079 Ribosomal_S4_CS # InterPro IPR022801 Ribosomal_S4/S9 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 M00179 Ribosome, archaea # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=23339.5; Method=MALDI; Range=2-206; Evidence={ECO:0000269|PubMed 10094780}; # Organism RS4_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11831 PTHR11831 # PATRIC 32122024 VBIEscCol129921_3389 # PDB 1EG0 EM; 11.50 A; A=43-200 # PDB 1M5G Model; -; D=2-206 # PDB 2YKR EM; 9.80 A; D=2-206 # PDB 3J9Y EM; 3.90 A; d=1-206 # PDB 3J9Z EM; 3.60 A; SD=2-206 # PDB 3JA1 EM; 3.60 A; SD=2-206 # PDB 3JBU EM; 3.64 A; D=1-206 # PDB 3JBV EM; 3.32 A; D=1-206 # PDB 3JCD EM; 3.70 A; d=1-206 # PDB 3JCE EM; 3.20 A; d=1-206 # PDB 3JCJ EM; 3.70 A; l=1-206 # PDB 3JCN EM; 4.60 A; g=1-206 # PDB 4A2I EM; 16.50 A; D=2-206 # PDB 4ADV EM; 13.50 A; D=2-206 # PDB 4U1U X-ray; 2.95 A; AD/CD=2-206 # PDB 4U1V X-ray; 3.00 A; AD/CD=2-206 # PDB 4U20 X-ray; 2.90 A; AD/CD=2-206 # PDB 4U24 X-ray; 2.90 A; AD/CD=2-206 # PDB 4U25 X-ray; 2.90 A; AD/CD=2-206 # PDB 4U26 X-ray; 2.80 A; AD/CD=2-206 # PDB 4U27 X-ray; 2.80 A; AD/CD=2-206 # PDB 4V47 EM; 12.30 A; BD=2-206 # PDB 4V48 EM; 11.50 A; BD=2-206 # PDB 4V4H X-ray; 3.46 A; AD/CD=1-206 # PDB 4V4Q X-ray; 3.46 A; AD/CD=2-206 # PDB 4V4V EM; 15.00 A; AD=3-206 # PDB 4V4W EM; 15.00 A; AD=3-206 # PDB 4V50 X-ray; 3.22 A; AD/CD=2-206 # PDB 4V52 X-ray; 3.21 A; AD/CD=2-206 # PDB 4V53 X-ray; 3.54 A; AD/CD=2-206 # PDB 4V54 X-ray; 3.30 A; AD/CD=2-206 # PDB 4V55 X-ray; 4.00 A; AD/CD=2-206 # PDB 4V56 X-ray; 3.93 A; AD/CD=2-206 # PDB 4V57 X-ray; 3.50 A; AD/CD=2-206 # PDB 4V5B X-ray; 3.74 A; BD/DD=2-206 # PDB 4V5H EM; 5.80 A; AD=2-206 # PDB 4V5Y X-ray; 4.45 A; AD/CD=2-206 # PDB 4V64 X-ray; 3.50 A; AD/CD=2-206 # PDB 4V65 EM; 9.00 A; AR=1-206 # PDB 4V66 EM; 9.00 A; AR=1-206 # PDB 4V69 EM; 6.70 A; AD=2-206 # PDB 4V6C X-ray; 3.19 A; AD/CD=1-206 # PDB 4V6D X-ray; 3.81 A; AD/CD=1-206 # PDB 4V6E X-ray; 3.71 A; AD/CD=1-206 # PDB 4V6K EM; 8.25 A; BH=1-206 # PDB 4V6L EM; 13.20 A; AH=1-206 # PDB 4V6M EM; 7.10 A; AD=2-206 # PDB 4V6N EM; 12.10 A; BG=2-206 # PDB 4V6O EM; 14.70 A; AG=2-206 # PDB 4V6P EM; 13.50 A; AG=2-206 # PDB 4V6Q EM; 11.50 A; AG=2-206 # PDB 4V6R EM; 11.50 A; AG=2-206 # PDB 4V6S EM; 13.10 A; BF=2-206 # PDB 4V6T EM; 8.30 A; AD=2-206 # PDB 4V6V EM; 9.80 A; AD=2-206 # PDB 4V6Y EM; 12.00 A; AD=1-206 # PDB 4V6Z EM; 12.00 A; AD=1-206 # PDB 4V70 EM; 17.00 A; AD=1-206 # PDB 4V71 EM; 20.00 A; AD=1-206 # PDB 4V72 EM; 13.00 A; AD=1-206 # PDB 4V73 EM; 15.00 A; AD=1-206 # PDB 4V74 EM; 17.00 A; AD=1-206 # PDB 4V75 EM; 12.00 A; AD=1-206 # PDB 4V76 EM; 17.00 A; AD=1-206 # PDB 4V77 EM; 17.00 A; AD=1-206 # PDB 4V78 EM; 20.00 A; AD=1-206 # PDB 4V79 EM; 15.00 A; AD=1-206 # PDB 4V7A EM; 9.00 A; AD=1-206 # PDB 4V7B EM; 6.80 A; AD=1-206 # PDB 4V7C EM; 7.60 A; AD=2-206 # PDB 4V7D EM; 7.60 A; BD=2-206 # PDB 4V7I EM; 9.60 A; BD=1-206 # PDB 4V7S X-ray; 3.25 A; AD/CD=2-206 # PDB 4V7T X-ray; 3.19 A; AD/CD=2-206 # PDB 4V7U X-ray; 3.10 A; AD/CD=2-206 # PDB 4V7V X-ray; 3.29 A; AD/CD=2-206 # PDB 4V85 X-ray; 3.20 A; AD=1-206 # PDB 4V89 X-ray; 3.70 A; AD=1-206 # PDB 4V9C X-ray; 3.30 A; AD/CD=1-206 # PDB 4V9D X-ray; 3.00 A; AD/BD=2-206 # PDB 4V9O X-ray; 2.90 A; BD/DD/FD/HD=1-206 # PDB 4V9P X-ray; 2.90 A; BD/DD/FD/HD=1-206 # PDB 4WF1 X-ray; 3.09 A; AD/CD=2-206 # PDB 4WOI X-ray; 3.00 A; AD/DD=1-206 # PDB 4WWW X-ray; 3.10 A; QD/XD=2-206 # PDB 4YBB X-ray; 2.10 A; AD/BD=2-206 # PDB 5AFI EM; 2.90 A; d=1-206 # PDB 5IQR EM; 3.00 A; i=1-206 # PDB 5IT8 X-ray; 3.12 A; AD/BD=2-206 # PDB 5J5B X-ray; 2.80 A; AD/BD=2-206 # PDB 5J7L X-ray; 3.00 A; AD/BD=2-206 # PDB 5J88 X-ray; 3.32 A; AD/BD=2-206 # PDB 5J8A X-ray; 3.10 A; AD/BD=2-206 # PDB 5J91 X-ray; 2.96 A; AD/BD=2-206 # PDB 5JC9 X-ray; 3.03 A; AD/BD=2-206 # PDB 5JTE EM; 3.60 A; AD=1-206 # PDB 5JU8 EM; 3.60 A; AD=1-206 # PDB 5KCR EM; 3.60 A; 1d=1-206 # PDB 5KCS EM; 3.90 A; 1d=1-206 # PDB 5KPS EM; 3.90 A; 9=1-206 # PDB 5KPV EM; 4.10 A; 8=1-206 # PDB 5KPW EM; 3.90 A; 8=1-206 # PDB 5KPX EM; 3.90 A; 8=1-206 # PDB 5L3P EM; 3.70 A; d=1-206 # PIR C23807 R3EC4 # PROSITE PS00632 RIBOSOMAL_S4 # PROSITE PS50889 S4 # Pfam PF00163 Ribosomal_S4 # Pfam PF01479 S4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RS4_ECOLI 30S ribosomal protein S4 # RefSeq NP_417755 NC_000913.3 # RefSeq WP_000135224 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein S4P family. {ECO 0000305}. # SIMILARITY Contains 1 S4 RNA-binding domain. {ECO 0000305}. # SMART SM00363 S4 # SMART SM01390 Ribosomal_S4 # SUBUNIT RS4_ECOLI Part of the 30S ribosomal subunit. Contacts protein S5. With proteins S3 and S5 encircles the mRNA as it enters the ribosome, which may play a role in mRNA helicase processivity. Some nascent polypeptide chains are able to cross-link to this protein in situ. # TIGRFAMs TIGR01017 rpsD_bact # eggNOG COG0522 LUCA # eggNOG ENOG4105G6W Bacteria BLAST swissprot:RS4_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RS4_ECOLI BioCyc ECOL316407:JW3258-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3258-MONOMER BioCyc EcoCyc:EG10903-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10903-MONOMER BioCyc MetaCyc:EG10903-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10903-MONOMER COG COG0522 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0522 DIP DIP-35794N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35794N DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1016/0014-5793(73)80383-7 http://dx.doi.org/10.1016/0014-5793(73)80383-7 DOI 10.1016/0022-2836(87)90694-2 http://dx.doi.org/10.1016/0022-2836(87)90694-2 DOI 10.1016/0022-2836(89)90509-3 http://dx.doi.org/10.1016/0022-2836(89)90509-3 DOI 10.1016/S0092-8674(03)00427-6 http://dx.doi.org/10.1016/S0092-8674(03)00427-6 DOI 10.1016/S0300-9084(00)01160-3 http://dx.doi.org/10.1016/S0300-9084(00)01160-3 DOI 10.1016/j.cell.2004.11.042 http://dx.doi.org/10.1016/j.cell.2004.11.042 DOI 10.1021/bi00418a057 http://dx.doi.org/10.1021/bi00418a057 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb841 http://dx.doi.org/10.1038/nsb841 DOI 10.1046/j.1432-1327.1998.2550409.x http://dx.doi.org/10.1046/j.1432-1327.1998.2550409.x DOI 10.1074/jbc.270.39.22939 http://dx.doi.org/10.1074/jbc.270.39.22939 DOI 10.1093/emboj/20.14.3811 http://dx.doi.org/10.1093/emboj/20.14.3811 DOI 10.1093/nar/13.11.3891 http://dx.doi.org/10.1093/nar/13.11.3891 DOI 10.1111/j.1432-1033.1975.tb02253.x http://dx.doi.org/10.1111/j.1432-1033.1975.tb02253.x DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB00254 http://www.drugbank.ca/drugs/DB00254 DrugBank DB00256 http://www.drugbank.ca/drugs/DB00256 DrugBank DB00453 http://www.drugbank.ca/drugs/DB00453 DrugBank DB00595 http://www.drugbank.ca/drugs/DB00595 DrugBank DB00618 http://www.drugbank.ca/drugs/DB00618 DrugBank DB01017 http://www.drugbank.ca/drugs/DB01017 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01685 http://www.ebi.ac.uk/ena/data/view/J01685 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL V00353 http://www.ebi.ac.uk/ena/data/view/V00353 EMBL X02543 http://www.ebi.ac.uk/ena/data/view/X02543 EchoBASE EB0896 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0896 EcoGene EG10903 http://www.ecogene.org/geneInfo.php?eg_id=EG10903 EnsemblBacteria AAC76321 http://www.ensemblgenomes.org/id/AAC76321 EnsemblBacteria AAC76321 http://www.ensemblgenomes.org/id/AAC76321 EnsemblBacteria BAE77995 http://www.ensemblgenomes.org/id/BAE77995 EnsemblBacteria BAE77995 http://www.ensemblgenomes.org/id/BAE77995 EnsemblBacteria BAE77995 http://www.ensemblgenomes.org/id/BAE77995 EnsemblBacteria b3296 http://www.ensemblgenomes.org/id/b3296 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0022627 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022627 GO_function GO:0000900 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000900 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GO_function GO:0048027 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048027 GO_process GO:0006353 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006353 GO_process GO:0031564 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031564 GO_process GO:0045903 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045903 GO_process GO:0045947 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045947 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GO_process GO:1990145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1990145 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003729 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003729 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.1050.10 http://www.cathdb.info/version/latest/superfamily/1.10.1050.10 Gene3D 3.10.290.10 http://www.cathdb.info/version/latest/superfamily/3.10.290.10 GeneID 947793 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947793 HAMAP MF_01306_B http://hamap.expasy.org/unirule/MF_01306_B HOGENOM HOG000221003 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000221003&db=HOGENOM6 InParanoid P0A7V8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7V8 IntAct P0A7V8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7V8* InterPro IPR001912 http://www.ebi.ac.uk/interpro/entry/IPR001912 InterPro IPR002942 http://www.ebi.ac.uk/interpro/entry/IPR002942 InterPro IPR005709 http://www.ebi.ac.uk/interpro/entry/IPR005709 InterPro IPR018079 http://www.ebi.ac.uk/interpro/entry/IPR018079 InterPro IPR022801 http://www.ebi.ac.uk/interpro/entry/IPR022801 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW3258 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3258 KEGG_Gene eco:b3296 http://www.genome.jp/dbget-bin/www_bget?eco:b3296 KEGG_Orthology KO:K02986 http://www.genome.jp/dbget-bin/www_bget?KO:K02986 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 MINT MINT-6478162 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-6478162 OMA RTSDYGN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RTSDYGN PANTHER PTHR11831 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11831 PDB 1EG0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1EG0 PDB 1M5G http://www.ebi.ac.uk/pdbe-srv/view/entry/1M5G PDB 2YKR http://www.ebi.ac.uk/pdbe-srv/view/entry/2YKR PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 4A2I http://www.ebi.ac.uk/pdbe-srv/view/entry/4A2I PDB 4ADV http://www.ebi.ac.uk/pdbe-srv/view/entry/4ADV PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4V47 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V47 PDB 4V48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V48 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 1EG0 http://www.ebi.ac.uk/pdbsum/1EG0 PDBsum 1M5G http://www.ebi.ac.uk/pdbsum/1M5G PDBsum 2YKR http://www.ebi.ac.uk/pdbsum/2YKR PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 4A2I http://www.ebi.ac.uk/pdbsum/4A2I PDBsum 4ADV http://www.ebi.ac.uk/pdbsum/4ADV PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4V47 http://www.ebi.ac.uk/pdbsum/4V47 PDBsum 4V48 http://www.ebi.ac.uk/pdbsum/4V48 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PROSITE PS00632 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00632 PROSITE PS50889 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50889 PSORT swissprot:RS4_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RS4_ECOLI PSORT-B swissprot:RS4_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RS4_ECOLI PSORT2 swissprot:RS4_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RS4_ECOLI Pfam PF00163 http://pfam.xfam.org/family/PF00163 Pfam PF01479 http://pfam.xfam.org/family/PF01479 Phobius swissprot:RS4_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RS4_ECOLI PhylomeDB P0A7V8 http://phylomedb.org/?seqid=P0A7V8 ProteinModelPortal P0A7V8 http://www.proteinmodelportal.org/query/uniprot/P0A7V8 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 1100394 http://www.ncbi.nlm.nih.gov/pubmed/1100394 PubMed 11018284 http://www.ncbi.nlm.nih.gov/pubmed/11018284 PubMed 11447122 http://www.ncbi.nlm.nih.gov/pubmed/11447122 PubMed 12244297 http://www.ncbi.nlm.nih.gov/pubmed/12244297 PubMed 12809609 http://www.ncbi.nlm.nih.gov/pubmed/12809609 PubMed 15652481 http://www.ncbi.nlm.nih.gov/pubmed/15652481 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2461734 http://www.ncbi.nlm.nih.gov/pubmed/2461734 PubMed 2477554 http://www.ncbi.nlm.nih.gov/pubmed/2477554 PubMed 2989779 http://www.ncbi.nlm.nih.gov/pubmed/2989779 PubMed 3309351 http://www.ncbi.nlm.nih.gov/pubmed/3309351 PubMed 387752 http://www.ncbi.nlm.nih.gov/pubmed/387752 PubMed 4587210 http://www.ncbi.nlm.nih.gov/pubmed/4587210 PubMed 7556101 http://www.ncbi.nlm.nih.gov/pubmed/7556101 PubMed 7559430 http://www.ncbi.nlm.nih.gov/pubmed/7559430 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9716382 http://www.ncbi.nlm.nih.gov/pubmed/9716382 RefSeq NP_417755 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417755 RefSeq WP_000135224 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000135224 SMART SM00363 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00363 SMART SM01390 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01390 SMR P0A7V8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7V8 STRING 511145.b3296 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3296&targetmode=cogs STRING COG0522 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0522&targetmode=cogs TIGRFAMs TIGR01017 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01017 UniProtKB RS4_ECOLI http://www.uniprot.org/uniprot/RS4_ECOLI UniProtKB-AC P0A7V8 http://www.uniprot.org/uniprot/P0A7V8 charge swissprot:RS4_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RS4_ECOLI eggNOG COG0522 http://eggnogapi.embl.de/nog_data/html/tree/COG0522 eggNOG ENOG4105G6W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105G6W epestfind swissprot:RS4_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RS4_ECOLI garnier swissprot:RS4_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RS4_ECOLI helixturnhelix swissprot:RS4_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RS4_ECOLI hmoment swissprot:RS4_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RS4_ECOLI iep swissprot:RS4_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RS4_ECOLI inforesidue swissprot:RS4_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RS4_ECOLI octanol swissprot:RS4_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RS4_ECOLI pepcoil swissprot:RS4_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RS4_ECOLI pepdigest swissprot:RS4_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RS4_ECOLI pepinfo swissprot:RS4_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RS4_ECOLI pepnet swissprot:RS4_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RS4_ECOLI pepstats swissprot:RS4_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RS4_ECOLI pepwheel swissprot:RS4_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RS4_ECOLI pepwindow swissprot:RS4_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RS4_ECOLI sigcleave swissprot:RS4_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RS4_ECOLI ## Database ID URL or Descriptions # BioGrid 4261927 247 # EcoGene EG12120 rssA # GO_function GO:0004622 lysophospholipase activity; IEA:InterPro. # GO_function GO:0016787 hydrolase activity; IBA:GO_Central. # GO_process GO:0046470 phosphatidylcholine metabolic process; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006629 lipid metabolic process # InterPro IPR001423 LysoPLipase_patatin_CS # InterPro IPR002641 Patatin/PLipase_A2-rel # InterPro IPR016035 Acyl_Trfase/lysoPLipase # Organism RSSA_ECOLI Escherichia coli (strain K12) # PATRIC 32117724 VBIEscCol129921_1282 # PIR B36871 B36871 # PROSITE PS01237 UPF0028 # PROSITE PS51635 PNPLA # Pfam PF01734 Patatin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RSSA_ECOLI NTE family protein RssA # RefSeq NP_415750 NC_000913.3 # RefSeq WP_001295622 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA36102.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the NTE family. {ECO 0000305}. # SIMILARITY Contains 1 PNPLA (patatin-like phospholipase) domain. {ECO:0000255|PROSITE-ProRule PRU01161}. # SUPFAM SSF52151 SSF52151 # eggNOG COG1752 LUCA # eggNOG ENOG4105D78 Bacteria BLAST swissprot:RSSA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RSSA_ECOLI BioCyc ECOL316407:JW1222-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1222-MONOMER BioCyc EcoCyc:EG12120-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12120-MONOMER COG COG1752 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1752 DIP DIP-35948N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35948N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M64675 http://www.ebi.ac.uk/ena/data/view/M64675 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2041 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2041 EcoGene EG12120 http://www.ecogene.org/geneInfo.php?eg_id=EG12120 EnsemblBacteria AAC74316 http://www.ensemblgenomes.org/id/AAC74316 EnsemblBacteria AAC74316 http://www.ensemblgenomes.org/id/AAC74316 EnsemblBacteria BAA36102 http://www.ensemblgenomes.org/id/BAA36102 EnsemblBacteria BAA36102 http://www.ensemblgenomes.org/id/BAA36102 EnsemblBacteria BAA36102 http://www.ensemblgenomes.org/id/BAA36102 EnsemblBacteria b1234 http://www.ensemblgenomes.org/id/b1234 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004622 GO_function GO:0016787 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016787 GO_process GO:0046470 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046470 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GeneID 945725 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945725 HOGENOM HOG000261886 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261886&db=HOGENOM6 InParanoid P0AFR0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFR0 IntAct P0AFR0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFR0* InterPro IPR001423 http://www.ebi.ac.uk/interpro/entry/IPR001423 InterPro IPR002641 http://www.ebi.ac.uk/interpro/entry/IPR002641 InterPro IPR016035 http://www.ebi.ac.uk/interpro/entry/IPR016035 KEGG_Gene ecj:JW1222 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1222 KEGG_Gene eco:b1234 http://www.genome.jp/dbget-bin/www_bget?eco:b1234 KEGG_Orthology KO:K07001 http://www.genome.jp/dbget-bin/www_bget?KO:K07001 PROSITE PS01237 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01237 PROSITE PS51635 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51635 PSORT swissprot:RSSA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RSSA_ECOLI PSORT-B swissprot:RSSA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RSSA_ECOLI PSORT2 swissprot:RSSA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RSSA_ECOLI Pfam PF01734 http://pfam.xfam.org/family/PF01734 Phobius swissprot:RSSA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RSSA_ECOLI PhylomeDB P0AFR0 http://phylomedb.org/?seqid=P0AFR0 ProteinModelPortal P0AFR0 http://www.proteinmodelportal.org/query/uniprot/P0AFR0 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8282700 http://www.ncbi.nlm.nih.gov/pubmed/8282700 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415750 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415750 RefSeq WP_001295622 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295622 SMR P0AFR0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFR0 STRING 511145.b1234 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1234&targetmode=cogs STRING COG1752 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1752&targetmode=cogs SUPFAM SSF52151 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52151 UniProtKB RSSA_ECOLI http://www.uniprot.org/uniprot/RSSA_ECOLI UniProtKB-AC P0AFR0 http://www.uniprot.org/uniprot/P0AFR0 charge swissprot:RSSA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RSSA_ECOLI eggNOG COG1752 http://eggnogapi.embl.de/nog_data/html/tree/COG1752 eggNOG ENOG4105D78 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D78 epestfind swissprot:RSSA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RSSA_ECOLI garnier swissprot:RSSA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RSSA_ECOLI helixturnhelix swissprot:RSSA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RSSA_ECOLI hmoment swissprot:RSSA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RSSA_ECOLI iep swissprot:RSSA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RSSA_ECOLI inforesidue swissprot:RSSA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RSSA_ECOLI octanol swissprot:RSSA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RSSA_ECOLI pepcoil swissprot:RSSA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RSSA_ECOLI pepdigest swissprot:RSSA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RSSA_ECOLI pepinfo swissprot:RSSA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RSSA_ECOLI pepnet swissprot:RSSA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RSSA_ECOLI pepstats swissprot:RSSA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RSSA_ECOLI pepwheel swissprot:RSSA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RSSA_ECOLI pepwindow swissprot:RSSA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RSSA_ECOLI sigcleave swissprot:RSSA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RSSA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261733 3 # EcoGene EG14424 yobH # InterPro IPR025611 YobH # Organism YOBH_ECOLI Escherichia coli (strain K12) # PATRIC 32118973 VBIEscCol129921_1904 # Pfam PF13996 YobH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YOBH_ECOLI Uncharacterized protein YobH # RefSeq WP_001211011 NZ_LN832404.1 # RefSeq YP_588456 NC_000913.3 # eggNOG ENOG4105TIK Bacteria # eggNOG ENOG41124K1 LUCA BLAST swissprot:YOBH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YOBH_ECOLI BioCyc ECOL316407:JW5298-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5298-MONOMER BioCyc EcoCyc:MONOMER0-2676 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2676 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14424 http://www.ecogene.org/geneInfo.php?eg_id=EG14424 EnsemblBacteria ABD18672 http://www.ensemblgenomes.org/id/ABD18672 EnsemblBacteria ABD18672 http://www.ensemblgenomes.org/id/ABD18672 EnsemblBacteria BAE76540 http://www.ensemblgenomes.org/id/BAE76540 EnsemblBacteria BAE76540 http://www.ensemblgenomes.org/id/BAE76540 EnsemblBacteria BAE76540 http://www.ensemblgenomes.org/id/BAE76540 EnsemblBacteria b4536 http://www.ensemblgenomes.org/id/b4536 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1450271 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1450271 HOGENOM HOG000219304 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219304&db=HOGENOM6 InterPro IPR025611 http://www.ebi.ac.uk/interpro/entry/IPR025611 KEGG_Gene ecj:JW5298 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5298 KEGG_Gene eco:b4536 http://www.genome.jp/dbget-bin/www_bget?eco:b4536 OMA TAQYVHS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TAQYVHS PSORT swissprot:YOBH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YOBH_ECOLI PSORT-B swissprot:YOBH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YOBH_ECOLI PSORT2 swissprot:YOBH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YOBH_ECOLI Pfam PF13996 http://pfam.xfam.org/family/PF13996 Phobius swissprot:YOBH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YOBH_ECOLI ProteinModelPortal Q2MB16 http://www.proteinmodelportal.org/query/uniprot/Q2MB16 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001211011 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001211011 RefSeq YP_588456 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_588456 STRING 511145.b4536 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4536&targetmode=cogs UniProtKB YOBH_ECOLI http://www.uniprot.org/uniprot/YOBH_ECOLI UniProtKB-AC Q2MB16 http://www.uniprot.org/uniprot/Q2MB16 charge swissprot:YOBH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YOBH_ECOLI eggNOG ENOG4105TIK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105TIK eggNOG ENOG41124K1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41124K1 epestfind swissprot:YOBH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YOBH_ECOLI garnier swissprot:YOBH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YOBH_ECOLI helixturnhelix swissprot:YOBH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YOBH_ECOLI hmoment swissprot:YOBH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YOBH_ECOLI iep swissprot:YOBH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YOBH_ECOLI inforesidue swissprot:YOBH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YOBH_ECOLI octanol swissprot:YOBH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YOBH_ECOLI pepcoil swissprot:YOBH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YOBH_ECOLI pepdigest swissprot:YOBH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YOBH_ECOLI pepinfo swissprot:YOBH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YOBH_ECOLI pepnet swissprot:YOBH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YOBH_ECOLI pepstats swissprot:YOBH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YOBH_ECOLI pepwheel swissprot:YOBH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YOBH_ECOLI pepwindow swissprot:YOBH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YOBH_ECOLI sigcleave swissprot:YOBH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YOBH_ECOLI ## Database ID URL or Descriptions # AltName FABI_ECOLI NADH-dependent enoyl-ACP reductase # BIOPHYSICOCHEMICAL PROPERTIES FABI_ECOLI Kinetic parameters KM=3.3 uM for trans-2-dodecenoyl-ACP (DD-ACP)(at 25 degrees Celsius and pH 8) {ECO 0000269|PubMed 17012233, ECO 0000269|PubMed 8119879}; KM=22 uM for crotonyl-ACP (at 30 degrees Celsius and pH 7.5) {ECO 0000269|PubMed 17012233, ECO 0000269|PubMed 8119879}; KM=24 uM for trans-2-dodecenoyl-CoA (DD-CoA)(at 25 degrees Celsius and pH 8) {ECO 0000269|PubMed 17012233, ECO 0000269|PubMed 8119879}; KM=2700 uM for crotonyl-CoA (at 30 degrees Celsius and pH 7.5) {ECO 0000269|PubMed 17012233, ECO 0000269|PubMed 8119879}; # BRENDA 1.3.1 2026 # BioGrid 4260135 284 # CATALYTIC ACTIVITY An acyl-[acyl-carrier protein] + NAD(+) = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH. {ECO:0000269|PubMed 8119879}. # DrugBank DB08604 Triclosan # ENZYME REGULATION FABI_ECOLI Inhibited by diazaborines, triclosan (5-chloro- 2-2,4-dichlorophenoxyphenol), 1,4-disubstituted imidazoles, 1,4- benzodiazepine derivatives, naphthyridinone derivatives, luteolin and curcumin. {ECO 0000269|PubMed 10398587, ECO 0000269|PubMed 10493822, ECO 0000269|PubMed 11514139, ECO 0000269|PubMed 12109908, ECO 0000269|PubMed 12699381, ECO 0000269|PubMed 19959361, ECO 0000269|PubMed 8119879, ECO 0000269|PubMed 8953047, ECO 0000269|PubMed 9707111}. # EcoGene EG11528 fabI # FUNCTION FABI_ECOLI Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism and in the biotin biosynthesis. {ECO 0000269|PubMed 20693992, ECO 0000269|PubMed 7592873, ECO 0000269|PubMed 8119879}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0004318 enoyl-[acyl-carrier-protein] reductase (NADH) activity; IDA:UniProtKB. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0008610 lipid biosynthetic process; IDA:EcoCyc. # GO_process GO:0009102 biotin biosynthetic process; IMP:UniProtKB. # GO_process GO:0030497 fatty acid elongation; IDA:UniProtKB. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GO_process GO:0051289 protein homotetramerization; IDA:UniProtKB. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.720 -; 1. # IntAct P0AEK4 12 # InterPro IPR002347 SDR_fam # InterPro IPR014358 Enoyl-ACP_Rdtase_NADH # InterPro IPR016040 NAD(P)-bd_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01004 Lipid biosynthesis proteins # KEGG_Pathway ko00061 Fatty acid biosynthesis # KEGG_Pathway ko00780 Biotin metabolism # MISCELLANEOUS FABI_ECOLI The antibiotic diazaborine interferes with the activity by binding to the protein and NAD. # Organism FABI_ECOLI Escherichia coli (strain K12) # PANTHER PTHR24322 PTHR24322; 2 # PANTHER PTHR24322:SF317 PTHR24322:SF317; 2 # PATHWAY FABI_ECOLI Cofactor biosynthesis; biotin biosynthesis. # PATHWAY FABI_ECOLI Lipid metabolism; fatty acid biosynthesis. # PATRIC 32117844 VBIEscCol129921_1342 # PDB 1C14 X-ray; 2.00 A; A/B=1-262 # PDB 1D8A X-ray; 2.20 A; A/B=2-262 # PDB 1DFG X-ray; 2.50 A; A/B=2-262 # PDB 1DFH X-ray; 2.20 A; A/B=2-262 # PDB 1DFI X-ray; 2.09 A; A/B/C/D=2-262 # PDB 1I2Z X-ray; 2.80 A; A/B=1-262 # PDB 1I30 X-ray; 2.40 A; A/B=1-262 # PDB 1LX6 X-ray; 2.40 A; A/B=1-262 # PDB 1LXC X-ray; 2.40 A; A/B=1-262 # PDB 1MFP X-ray; 2.33 A; A/B=1-262 # PDB 1QG6 X-ray; 1.90 A; A/B/C/D=2-262 # PDB 1QSG X-ray; 1.75 A; A/B/C/D/E/F/G/H=1-262 # PDB 2FHS X-ray; 2.70 A; A/B=1-262 # PDB 3PJD X-ray; 2.50 A; A/B=1-262 # PDB 3PJE X-ray; 2.50 A; A/B=1-262 # PDB 3PJF X-ray; 1.90 A; A/B=1-262 # PDB 4JQC X-ray; 2.80 A; A/B=1-262 # PDB 4JX8 X-ray; 3.20 A; A/B=1-262 # PDB 5CFZ X-ray; 1.97 A; A/B=1-262 # PDB 5CG1 X-ray; 2.07 A; A/B=1-262 # PDB 5CG2 X-ray; 2.11 A; A/B=1-262 # PIR S48029 S48029 # PIRSF PIRSF000094 Enoyl-ACP_rdct # PRINTS PR00081 GDHRDH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FABI_ECOLI Enoyl-[acyl-carrier-protein] reductase [NADH] FabI # RefSeq NP_415804 NC_000913.3 # RefSeq WP_000506490 NZ_LN832404.1 # SIMILARITY Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily. {ECO 0000305}. # SUBUNIT FABI_ECOLI Homotetramer. {ECO 0000269|PubMed 10201369, ECO 0000269|PubMed 10398587, ECO 0000269|PubMed 10493822, ECO 0000269|PubMed 10595560, ECO 0000269|PubMed 11514139, ECO 0000269|PubMed 12109908, ECO 0000269|PubMed 12699381, ECO 0000269|PubMed 8953047}. # SUPFAM SSF51735 SSF51735 # eggNOG COG0623 LUCA # eggNOG ENOG4105CSJ Bacteria BLAST swissprot:FABI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FABI_ECOLI BioCyc ECOL316407:JW1281-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1281-MONOMER BioCyc EcoCyc:ENOYL-ACP-REDUCT-NADH-MONOMER http://biocyc.org/getid?id=EcoCyc:ENOYL-ACP-REDUCT-NADH-MONOMER BioCyc MetaCyc:ENOYL-ACP-REDUCT-NADH-MONOMER http://biocyc.org/getid?id=MetaCyc:ENOYL-ACP-REDUCT-NADH-MONOMER COG COG0623 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0623 DIP DIP-31867N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31867N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1999.2907 http://dx.doi.org/10.1006/jmbi.1999.2907 DOI 10.1007/BF00028873 http://dx.doi.org/10.1007/BF00028873 DOI 10.1016/S0960-894X(01)00404-8 http://dx.doi.org/10.1016/S0960-894X(01)00404-8 DOI 10.1016/j.bmcl.2009.11.042 http://dx.doi.org/10.1016/j.bmcl.2009.11.042 DOI 10.1021/bi9907779 http://dx.doi.org/10.1021/bi9907779 DOI 10.1021/jm020050+ http://dx.doi.org/10.1021/jm020050+ DOI 10.1021/jm0204035 http://dx.doi.org/10.1021/jm0204035 DOI 10.1038/18803 http://dx.doi.org/10.1038/18803 DOI 10.1038/28970 http://dx.doi.org/10.1038/28970 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nchembio.420 http://dx.doi.org/10.1038/nchembio.420 DOI 10.1074/jbc.270.44.26538 http://dx.doi.org/10.1074/jbc.270.44.26538 DOI 10.1074/jbc.M608758200 http://dx.doi.org/10.1074/jbc.M608758200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1099/00221287-138-10-2093 http://dx.doi.org/10.1099/00221287-138-10-2093 DOI 10.1110/ps.8.11.2529 http://dx.doi.org/10.1110/ps.8.11.2529 DOI 10.1126/science.274.5295.2107 http://dx.doi.org/10.1126/science.274.5295.2107 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB08604 http://www.drugbank.ca/drugs/DB08604 EC_number EC:1.3.1.9 http://www.genome.jp/dbget-bin/www_bget?EC:1.3.1.9 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M97219 http://www.ebi.ac.uk/ena/data/view/M97219 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X78733 http://www.ebi.ac.uk/ena/data/view/X78733 ENZYME 1.3.1.9 http://enzyme.expasy.org/EC/1.3.1.9 EchoBASE EB1490 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1490 EcoGene EG11528 http://www.ecogene.org/geneInfo.php?eg_id=EG11528 EnsemblBacteria AAC74370 http://www.ensemblgenomes.org/id/AAC74370 EnsemblBacteria AAC74370 http://www.ensemblgenomes.org/id/AAC74370 EnsemblBacteria BAA14841 http://www.ensemblgenomes.org/id/BAA14841 EnsemblBacteria BAA14841 http://www.ensemblgenomes.org/id/BAA14841 EnsemblBacteria BAA14841 http://www.ensemblgenomes.org/id/BAA14841 EnsemblBacteria b1288 http://www.ensemblgenomes.org/id/b1288 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0004318 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004318 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0008610 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008610 GO_process GO:0009102 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009102 GO_process GO:0030497 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030497 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GO_process GO:0051289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051289 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 945870 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945870 InParanoid P0AEK4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEK4 IntAct P0AEK4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEK4* IntEnz 1.3.1.9 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.3.1.9 InterPro IPR002347 http://www.ebi.ac.uk/interpro/entry/IPR002347 InterPro IPR014358 http://www.ebi.ac.uk/interpro/entry/IPR014358 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01004 http://www.genome.jp/dbget-bin/www_bget?ko01004 KEGG_Gene ecj:JW1281 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1281 KEGG_Gene eco:b1288 http://www.genome.jp/dbget-bin/www_bget?eco:b1288 KEGG_Orthology KO:K00208 http://www.genome.jp/dbget-bin/www_bget?KO:K00208 KEGG_Pathway ko00061 http://www.genome.jp/kegg-bin/show_pathway?ko00061 KEGG_Pathway ko00780 http://www.genome.jp/kegg-bin/show_pathway?ko00780 KEGG_Reaction rn:R04429 http://www.genome.jp/dbget-bin/www_bget?rn:R04429 KEGG_Reaction rn:R04724 http://www.genome.jp/dbget-bin/www_bget?rn:R04724 KEGG_Reaction rn:R04955 http://www.genome.jp/dbget-bin/www_bget?rn:R04955 KEGG_Reaction rn:R04958 http://www.genome.jp/dbget-bin/www_bget?rn:R04958 KEGG_Reaction rn:R04961 http://www.genome.jp/dbget-bin/www_bget?rn:R04961 KEGG_Reaction rn:R04966 http://www.genome.jp/dbget-bin/www_bget?rn:R04966 KEGG_Reaction rn:R04969 http://www.genome.jp/dbget-bin/www_bget?rn:R04969 KEGG_Reaction rn:R07765 http://www.genome.jp/dbget-bin/www_bget?rn:R07765 KEGG_Reaction rn:R10118 http://www.genome.jp/dbget-bin/www_bget?rn:R10118 KEGG_Reaction rn:R10122 http://www.genome.jp/dbget-bin/www_bget?rn:R10122 MINT MINT-1251203 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1251203 OMA SACKREG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SACKREG PANTHER PTHR24322 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24322 PANTHER PTHR24322:SF317 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24322:SF317 PDB 1C14 http://www.ebi.ac.uk/pdbe-srv/view/entry/1C14 PDB 1D8A http://www.ebi.ac.uk/pdbe-srv/view/entry/1D8A PDB 1DFG http://www.ebi.ac.uk/pdbe-srv/view/entry/1DFG PDB 1DFH http://www.ebi.ac.uk/pdbe-srv/view/entry/1DFH PDB 1DFI http://www.ebi.ac.uk/pdbe-srv/view/entry/1DFI PDB 1I2Z http://www.ebi.ac.uk/pdbe-srv/view/entry/1I2Z PDB 1I30 http://www.ebi.ac.uk/pdbe-srv/view/entry/1I30 PDB 1LX6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1LX6 PDB 1LXC http://www.ebi.ac.uk/pdbe-srv/view/entry/1LXC PDB 1MFP http://www.ebi.ac.uk/pdbe-srv/view/entry/1MFP PDB 1QG6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1QG6 PDB 1QSG http://www.ebi.ac.uk/pdbe-srv/view/entry/1QSG PDB 2FHS http://www.ebi.ac.uk/pdbe-srv/view/entry/2FHS PDB 3PJD http://www.ebi.ac.uk/pdbe-srv/view/entry/3PJD PDB 3PJE http://www.ebi.ac.uk/pdbe-srv/view/entry/3PJE PDB 3PJF http://www.ebi.ac.uk/pdbe-srv/view/entry/3PJF PDB 4JQC http://www.ebi.ac.uk/pdbe-srv/view/entry/4JQC PDB 4JX8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4JX8 PDB 5CFZ http://www.ebi.ac.uk/pdbe-srv/view/entry/5CFZ PDB 5CG1 http://www.ebi.ac.uk/pdbe-srv/view/entry/5CG1 PDB 5CG2 http://www.ebi.ac.uk/pdbe-srv/view/entry/5CG2 PDBsum 1C14 http://www.ebi.ac.uk/pdbsum/1C14 PDBsum 1D8A http://www.ebi.ac.uk/pdbsum/1D8A PDBsum 1DFG http://www.ebi.ac.uk/pdbsum/1DFG PDBsum 1DFH http://www.ebi.ac.uk/pdbsum/1DFH PDBsum 1DFI http://www.ebi.ac.uk/pdbsum/1DFI PDBsum 1I2Z http://www.ebi.ac.uk/pdbsum/1I2Z PDBsum 1I30 http://www.ebi.ac.uk/pdbsum/1I30 PDBsum 1LX6 http://www.ebi.ac.uk/pdbsum/1LX6 PDBsum 1LXC http://www.ebi.ac.uk/pdbsum/1LXC PDBsum 1MFP http://www.ebi.ac.uk/pdbsum/1MFP PDBsum 1QG6 http://www.ebi.ac.uk/pdbsum/1QG6 PDBsum 1QSG http://www.ebi.ac.uk/pdbsum/1QSG PDBsum 2FHS http://www.ebi.ac.uk/pdbsum/2FHS PDBsum 3PJD http://www.ebi.ac.uk/pdbsum/3PJD PDBsum 3PJE http://www.ebi.ac.uk/pdbsum/3PJE PDBsum 3PJF http://www.ebi.ac.uk/pdbsum/3PJF PDBsum 4JQC http://www.ebi.ac.uk/pdbsum/4JQC PDBsum 4JX8 http://www.ebi.ac.uk/pdbsum/4JX8 PDBsum 5CFZ http://www.ebi.ac.uk/pdbsum/5CFZ PDBsum 5CG1 http://www.ebi.ac.uk/pdbsum/5CG1 PDBsum 5CG2 http://www.ebi.ac.uk/pdbsum/5CG2 PRINTS PR00081 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00081 PSORT swissprot:FABI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FABI_ECOLI PSORT-B swissprot:FABI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FABI_ECOLI PSORT2 swissprot:FABI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FABI_ECOLI Phobius swissprot:FABI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FABI_ECOLI PhylomeDB P0AEK4 http://phylomedb.org/?seqid=P0AEK4 ProteinModelPortal P0AEK4 http://www.proteinmodelportal.org/query/uniprot/P0AEK4 PubMed 10201369 http://www.ncbi.nlm.nih.gov/pubmed/10201369 PubMed 10398587 http://www.ncbi.nlm.nih.gov/pubmed/10398587 PubMed 10493822 http://www.ncbi.nlm.nih.gov/pubmed/10493822 PubMed 10595560 http://www.ncbi.nlm.nih.gov/pubmed/10595560 PubMed 11514139 http://www.ncbi.nlm.nih.gov/pubmed/11514139 PubMed 12109908 http://www.ncbi.nlm.nih.gov/pubmed/12109908 PubMed 12699381 http://www.ncbi.nlm.nih.gov/pubmed/12699381 PubMed 1364817 http://www.ncbi.nlm.nih.gov/pubmed/1364817 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17012233 http://www.ncbi.nlm.nih.gov/pubmed/17012233 PubMed 19959361 http://www.ncbi.nlm.nih.gov/pubmed/19959361 PubMed 20693992 http://www.ncbi.nlm.nih.gov/pubmed/20693992 PubMed 7592873 http://www.ncbi.nlm.nih.gov/pubmed/7592873 PubMed 8075395 http://www.ncbi.nlm.nih.gov/pubmed/8075395 PubMed 8119879 http://www.ncbi.nlm.nih.gov/pubmed/8119879 PubMed 8953047 http://www.ncbi.nlm.nih.gov/pubmed/8953047 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9707111 http://www.ncbi.nlm.nih.gov/pubmed/9707111 RefSeq NP_415804 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415804 RefSeq WP_000506490 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000506490 SMR P0AEK4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEK4 STRING 511145.b1288 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1288&targetmode=cogs STRING COG0623 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0623&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 SWISS-2DPAGE P0AEK4 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AEK4 UniProtKB FABI_ECOLI http://www.uniprot.org/uniprot/FABI_ECOLI UniProtKB-AC P0AEK4 http://www.uniprot.org/uniprot/P0AEK4 charge swissprot:FABI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FABI_ECOLI eggNOG COG0623 http://eggnogapi.embl.de/nog_data/html/tree/COG0623 eggNOG ENOG4105CSJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CSJ epestfind swissprot:FABI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FABI_ECOLI garnier swissprot:FABI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FABI_ECOLI helixturnhelix swissprot:FABI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FABI_ECOLI hmoment swissprot:FABI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FABI_ECOLI iep swissprot:FABI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FABI_ECOLI inforesidue swissprot:FABI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FABI_ECOLI octanol swissprot:FABI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FABI_ECOLI pepcoil swissprot:FABI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FABI_ECOLI pepdigest swissprot:FABI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FABI_ECOLI pepinfo swissprot:FABI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FABI_ECOLI pepnet swissprot:FABI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FABI_ECOLI pepstats swissprot:FABI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FABI_ECOLI pepwheel swissprot:FABI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FABI_ECOLI pepwindow swissprot:FABI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FABI_ECOLI sigcleave swissprot:FABI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FABI_ECOLI ## Database ID URL or Descriptions # BioGrid 4260284 173 # CDD cd13835 IHF_A # EcoGene EG10440 ihfA # FUNCTION IHFA_ECOLI Has an essential role in conjugative DNA transfer (CDT), the unidirectional transfer of ssDNA plasmid from a donor to a recipient cell. It is the central mechanism by which antibiotic resistance and virulence factors are propagated in bacterial populations. Part of the relaxosome, which facilitates a site- and strand-specific cut in the origin of transfer by TraI, at the nic site. Relaxosome formation requires binding of IHF and TraY to the oriT region, which then faciliates binding of TraI. # FUNCTION IHFA_ECOLI One of the 2 subunits of integration host factor (IHF), a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Binds to hundreds of transcriptionally inactive, AT-rich DNA sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome (PubMed 16963779). {ECO 0000269|PubMed 16963779}. # FUNCTION IHFA_ECOLI Plays a crucial role in the lysogenic life cycle of bacteriophage lambda, as it is required not only in the recombination reaction, which inserts lambda DNA into the E.coli chromosome, but also for the synthesis of int and cI repressor, two phage proteins necessary for DNA insertion and repression, respectively. The synthesis of int and cI proteins is regulated indirectly by IHF via translational control of the lambda cII protein. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0009295 nucleoid; IEA:UniProtKB-SubCell. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-HAMAP. # GO_process GO:0000746 conjugation; IEA:UniProtKB-KW. # GO_process GO:0006310 DNA recombination; IEA:UniProtKB-HAMAP. # GO_process GO:0006351 transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0006417 regulation of translation; IEA:UniProtKB-HAMAP. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 4.10.520.10 -; 1. # HAMAP MF_00380 IHF_alpha # IntAct P0A6X7 21 # InterPro IPR000119 Hist_DNA-bd # InterPro IPR005684 IHF_alpha # InterPro IPR010992 IHF-like_DNA-bd_dom # InterPro IPR020816 Histone-like_DNA-bd_CS # KEGG_Brite ko03032 DNA replication proteins # KEGG_Brite ko03036 Chromosome # KEGG_Brite ko03400 DNA repair and recombination proteins # Organism IHFA_ECOLI Escherichia coli (strain K12) # PATRIC 32118730 VBIEscCol129921_1783 # PDB 1IHF X-ray; 2.20 A; A=1-99 # PDB 1OUZ X-ray; 2.41 A; A=1-99 # PDB 1OWF X-ray; 1.95 A; A=1-99 # PDB 1OWG X-ray; 2.10 A; A=1-99 # PDB 2HT0 X-ray; 2.00 A; A=1-99 # PDB 2IIE X-ray; 2.41 A; A=3-94 # PDB 2IIF X-ray; 2.72 A; A=3-94 # PIR C23099 IQECAA # PRINTS PR01727 DNABINDINGHU # PROSITE PS00045 HISTONE_LIKE # Pfam PF00216 Bac_DNA_binding # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName IHFA_ECOLI Integration host factor subunit alpha # RefSeq NP_416227 NC_000913.3 # RefSeq WP_001229265 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial histone-like protein family. {ECO 0000305}. # SMART SM00411 BHL # SUBCELLULAR LOCATION IHFA_ECOLI Cytoplasm, nucleoid {ECO 0000269|PubMed 21903814}. Note=Scattered throughout the nucleoid (PubMed 21903814). {ECO 0000269|PubMed 21903814}. # SUBUNIT IHFA_ECOLI Heterodimer of an alpha and a beta chain. Part of the relaxosome, a complex composed of plasmid-encoded TraI, TraM, TraY and host-encoded IHF bound to the F plasmid origin of transfer (oriT). {ECO 0000269|PubMed 17238924, ECO 0000269|PubMed 7499340}. # SUPFAM SSF47729 SSF47729 # TIGRFAMs TIGR00987 himA # eggNOG COG0776 LUCA BLAST swissprot:IHFA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:IHFA_ECOLI BioCyc ECOL316407:JW1702-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1702-MONOMER BioCyc EcoCyc:PD00347 http://biocyc.org/getid?id=EcoCyc:PD00347 COG COG0776 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0776 DIP DIP-36031N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36031N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/S0092-8674(00)81824-3 http://dx.doi.org/10.1016/S0092-8674(00)81824-3 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.270.47.28374 http://dx.doi.org/10.1074/jbc.270.47.28374 DOI 10.1074/jbc.270.47.28381 http://dx.doi.org/10.1074/jbc.270.47.28381 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/gkl542 http://dx.doi.org/10.1093/nar/gkl542 DOI 10.1111/j.1365-2958.2006.05576.x http://dx.doi.org/10.1111/j.1365-2958.2006.05576.x DOI 10.1111/j.1574-6968.1998.tb13343.x http://dx.doi.org/10.1111/j.1574-6968.1998.tb13343.x DOI 10.1126/science.1204697 http://dx.doi.org/10.1126/science.1204697 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K02844 http://www.ebi.ac.uk/ena/data/view/K02844 EMBL M14031 http://www.ebi.ac.uk/ena/data/view/M14031 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00291 http://www.ebi.ac.uk/ena/data/view/V00291 EchoBASE EB0435 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0435 EcoGene EG10440 http://www.ecogene.org/geneInfo.php?eg_id=EG10440 EnsemblBacteria AAC74782 http://www.ensemblgenomes.org/id/AAC74782 EnsemblBacteria AAC74782 http://www.ensemblgenomes.org/id/AAC74782 EnsemblBacteria BAA15480 http://www.ensemblgenomes.org/id/BAA15480 EnsemblBacteria BAA15480 http://www.ensemblgenomes.org/id/BAA15480 EnsemblBacteria BAA15480 http://www.ensemblgenomes.org/id/BAA15480 EnsemblBacteria b1712 http://www.ensemblgenomes.org/id/b1712 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0009295 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009295 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0000746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000746 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006417 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006417 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 4.10.520.10 http://www.cathdb.info/version/latest/superfamily/4.10.520.10 GeneID 945472 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945472 HAMAP MF_00380 http://hamap.expasy.org/unirule/MF_00380 HOGENOM HOG000043829 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000043829&db=HOGENOM6 InParanoid P0A6X7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6X7 IntAct P0A6X7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6X7* InterPro IPR000119 http://www.ebi.ac.uk/interpro/entry/IPR000119 InterPro IPR005684 http://www.ebi.ac.uk/interpro/entry/IPR005684 InterPro IPR010992 http://www.ebi.ac.uk/interpro/entry/IPR010992 InterPro IPR020816 http://www.ebi.ac.uk/interpro/entry/IPR020816 KEGG_Brite ko03032 http://www.genome.jp/dbget-bin/www_bget?ko03032 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW1702 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1702 KEGG_Gene eco:b1712 http://www.genome.jp/dbget-bin/www_bget?eco:b1712 KEGG_Orthology KO:K04764 http://www.genome.jp/dbget-bin/www_bget?KO:K04764 OMA FDLRDKK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FDLRDKK PDB 1IHF http://www.ebi.ac.uk/pdbe-srv/view/entry/1IHF PDB 1OUZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1OUZ PDB 1OWF http://www.ebi.ac.uk/pdbe-srv/view/entry/1OWF PDB 1OWG http://www.ebi.ac.uk/pdbe-srv/view/entry/1OWG PDB 2HT0 http://www.ebi.ac.uk/pdbe-srv/view/entry/2HT0 PDB 2IIE http://www.ebi.ac.uk/pdbe-srv/view/entry/2IIE PDB 2IIF http://www.ebi.ac.uk/pdbe-srv/view/entry/2IIF PDBsum 1IHF http://www.ebi.ac.uk/pdbsum/1IHF PDBsum 1OUZ http://www.ebi.ac.uk/pdbsum/1OUZ PDBsum 1OWF http://www.ebi.ac.uk/pdbsum/1OWF PDBsum 1OWG http://www.ebi.ac.uk/pdbsum/1OWG PDBsum 2HT0 http://www.ebi.ac.uk/pdbsum/2HT0 PDBsum 2IIE http://www.ebi.ac.uk/pdbsum/2IIE PDBsum 2IIF http://www.ebi.ac.uk/pdbsum/2IIF PRINTS PR01727 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01727 PROSITE PS00045 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00045 PSORT swissprot:IHFA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:IHFA_ECOLI PSORT-B swissprot:IHFA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:IHFA_ECOLI PSORT2 swissprot:IHFA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:IHFA_ECOLI Pfam PF00216 http://pfam.xfam.org/family/PF00216 Phobius swissprot:IHFA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:IHFA_ECOLI PhylomeDB P0A6X7 http://phylomedb.org/?seqid=P0A6X7 ProteinModelPortal P0A6X7 http://www.proteinmodelportal.org/query/uniprot/P0A6X7 PubMed 1531459 http://www.ncbi.nlm.nih.gov/pubmed/1531459 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16963779 http://www.ncbi.nlm.nih.gov/pubmed/16963779 PubMed 17238924 http://www.ncbi.nlm.nih.gov/pubmed/17238924 PubMed 21903814 http://www.ncbi.nlm.nih.gov/pubmed/21903814 PubMed 2991205 http://www.ncbi.nlm.nih.gov/pubmed/2991205 PubMed 3528129 http://www.ncbi.nlm.nih.gov/pubmed/3528129 PubMed 6397321 http://www.ncbi.nlm.nih.gov/pubmed/6397321 PubMed 7499339 http://www.ncbi.nlm.nih.gov/pubmed/7499339 PubMed 7499340 http://www.ncbi.nlm.nih.gov/pubmed/7499340 PubMed 8980235 http://www.ncbi.nlm.nih.gov/pubmed/8980235 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9868784 http://www.ncbi.nlm.nih.gov/pubmed/9868784 RefSeq NP_416227 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416227 RefSeq WP_001229265 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001229265 SMART SM00411 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00411 SMR P0A6X7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6X7 STRING 511145.b1712 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1712&targetmode=cogs STRING COG0776 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0776&targetmode=cogs SUPFAM SSF47729 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47729 TIGRFAMs TIGR00987 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00987 UniProtKB IHFA_ECOLI http://www.uniprot.org/uniprot/IHFA_ECOLI UniProtKB-AC P0A6X7 http://www.uniprot.org/uniprot/P0A6X7 charge swissprot:IHFA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:IHFA_ECOLI eggNOG COG0776 http://eggnogapi.embl.de/nog_data/html/tree/COG0776 epestfind swissprot:IHFA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:IHFA_ECOLI garnier swissprot:IHFA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:IHFA_ECOLI helixturnhelix swissprot:IHFA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:IHFA_ECOLI hmoment swissprot:IHFA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:IHFA_ECOLI iep swissprot:IHFA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:IHFA_ECOLI inforesidue swissprot:IHFA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:IHFA_ECOLI octanol swissprot:IHFA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:IHFA_ECOLI pepcoil swissprot:IHFA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:IHFA_ECOLI pepdigest swissprot:IHFA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:IHFA_ECOLI pepinfo swissprot:IHFA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:IHFA_ECOLI pepnet swissprot:IHFA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:IHFA_ECOLI pepstats swissprot:IHFA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:IHFA_ECOLI pepwheel swissprot:IHFA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:IHFA_ECOLI pepwindow swissprot:IHFA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:IHFA_ECOLI sigcleave swissprot:IHFA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:IHFA_ECOLI ## Database ID URL or Descriptions # AltName 2-phospho-D-glycerate hydro-lyase {ECO:0000255|HAMAP-Rule MF_00318} # AltName 2-phosphoglycerate dehydratase {ECO:0000255|HAMAP-Rule MF_00318} # BIOPHYSICOCHEMICAL PROPERTIES pH dependence: Optimum pH is 8.1. {ECO 0000269|PubMed:4942326}; # BRENDA 4.2.1.11 2026 # BioGrid 4262297 313 # CATALYTIC ACTIVITY ENO_ECOLI 2-phospho-D-glycerate = phosphoenolpyruvate + H(2)O. {ECO 0000255|HAMAP-Rule MF_00318, ECO 0000269|PubMed 4942326}. # CDD cd03313 enolase # COFACTOR ENO_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_00318, ECO 0000269|PubMed 11676541, ECO 0000269|PubMed 4942326}; Note=Mg(2+) is required for catalysis and for stabilizing the dimer. {ECO 0000255|HAMAP-Rule MF_00318, ECO 0000269|PubMed 11676541, ECO 0000269|PubMed 4942326}; # ENZYME REGULATION ENO_ECOLI The covalent binding to the substrate at Lys- 342 causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein. Inhibited by fluoride ion. {ECO 0000269|PubMed 15003462, ECO 0000269|PubMed 4942326}. # EcoGene EG10258 eno # FUNCTION ENO_ECOLI Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. It is also a component of the RNA degradosome, a multi-enzyme complex involved in RNA processing and messenger RNA degradation. Its interaction with RNase E is important for the turnover of mRNA, in particular on transcripts encoding enzymes of energy-generating metabolic routes. Its presence in the degradosome is required for the response to excess phosphosugar. May play a regulatory role in the degradation of specific RNAs, such as ptsG mRNA, therefore linking cellular metabolic status with post-translational gene regulation. {ECO 0000255|HAMAP-Rule MF_00318, ECO 0000269|PubMed 14981237, ECO 0000269|PubMed 15522087, ECO 0000269|PubMed 4942326}. # GO_component GO:0000015 phosphopyruvate hydratase complex; IEA:InterPro. # GO_component GO:0005576 extracellular region; IEA:UniProtKB-SubCell. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0005856 cytoskeleton; IPI:EcoCyc. # GO_component GO:0009986 cell surface; IEA:UniProtKB-SubCell. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0000287 magnesium ion binding; IDA:EcoliWiki. # GO_function GO:0004634 phosphopyruvate hydratase activity; IDA:EcoCyc. # GO_process GO:0006096 glycolytic process; IMP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005576 extracellular region # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005856 cytoskeleton # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.20.20.120 -; 1. # Gene3D 3.30.390.10 -; 1. # HAMAP MF_00318 Enolase # INTERACTION ENO_ECOLI Self; NbExp=2; IntAct=EBI-368855, EBI-368855; P21513 rne; NbExp=15; IntAct=EBI-368855, EBI-549958; # IntAct P0A6P9 31 # InterPro IPR000941 Enolase # InterPro IPR020809 Enolase_CS # InterPro IPR020810 Enolase_C # InterPro IPR020811 Enolase_N # InterPro IPR029017 Enolase_N-like # InterPro IPR029065 Enolase_C-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00010 Glycolysis / Gluconeogenesis # KEGG_Pathway ko00680 Methane metabolism # KEGG_Pathway ko03018 RNA degradation # KEGG_Pathway ko04066 HIF-1 signaling pathway # Organism ENO_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11902 PTHR11902 # PATHWAY Carbohydrate degradation; glycolysis; pyruvate from D- glyceraldehyde 3-phosphate: step 4/5. {ECO 0000255|HAMAP- Rule:MF_00318}. # PATRIC 32120974 VBIEscCol129921_2879 # PDB 1E9I X-ray; 2.48 A; A/B/C/D=2-432 # PDB 2FYM X-ray; 1.60 A; A/C/D/F=2-432 # PDB 3H8A X-ray; 1.90 A; A/B/C/D=1-432 # PIR G65059 NOEC # PIRSF PIRSF001400 Enolase # PRINTS PR00148 ENOLASE # PROSITE PS00164 ENOLASE # PTM ENO_ECOLI Phosphorylated on serine residue(s). {ECO 0000269|PubMed 2513001}. # Pfam PF00113 Enolase_C # Pfam PF03952 Enolase_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Enolase {ECO:0000255|HAMAP-Rule MF_00318} # RefSeq NP_417259 NC_000913.3 # RefSeq WP_000036723 NZ_LN832404.1 # SIMILARITY Belongs to the enolase family. {ECO:0000255|HAMAP- Rule MF_00318}. # SMART SM01192 Enolase_C # SMART SM01193 Enolase_N # SUBCELLULAR LOCATION ENO_ECOLI Cytoplasm, cytoskeleton. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. As part of the bacterial cytoskeleton in the cytoplasm, is organized as extended coiled structures that wind around the cell, from one cell pole to the other. When covalently bound to the substrate at Lys-342, the inactive enolase is secreted, and remains attached to the cell surface. # SUBUNIT ENO_ECOLI Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation. Interacts with the C-terminal region of the endoribonuclease RNase E. Homodimer. {ECO 0000255|HAMAP-Rule MF_00318, ECO 0000269|PubMed 11676541, ECO 0000269|PubMed 16516921, ECO 0000269|PubMed 18337249, ECO 0000269|PubMed 20823555, ECO 0000269|PubMed 4942326, ECO 0000269|PubMed 8610017, ECO 0000269|PubMed 9732274}. # SUPFAM SSF51604 SSF51604 # SUPFAM SSF54826 SSF54826 # TIGRFAMs TIGR01060 eno # UniPathway UPA00109 UER00187 # eggNOG COG0148 LUCA # eggNOG ENOG4105C70 Bacteria BLAST swissprot:ENO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ENO_ECOLI BioCyc ECOL316407:JW2750-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2750-MONOMER BioCyc EcoCyc:ENOLASE-MONOMER http://biocyc.org/getid?id=EcoCyc:ENOLASE-MONOMER BioCyc MetaCyc:ENOLASE-MONOMER http://biocyc.org/getid?id=MetaCyc:ENOLASE-MONOMER COG COG0148 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0148 DIP DIP-31847N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31847N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1998.1726 http://dx.doi.org/10.1006/jmbi.1998.1726 DOI 10.1006/jmbi.2001.5065 http://dx.doi.org/10.1006/jmbi.2001.5065 DOI 10.1016/0300-9084(89)90116-8 http://dx.doi.org/10.1016/0300-9084(89)90116-8 DOI 10.1016/j.jmb.2003.12.082 http://dx.doi.org/10.1016/j.jmb.2003.12.082 DOI 10.1016/j.jmb.2006.02.012 http://dx.doi.org/10.1016/j.jmb.2006.02.012 DOI 10.1038/381169a0 http://dx.doi.org/10.1038/381169a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0308747101 http://dx.doi.org/10.1073/pnas.0308747101 DOI 10.1073/pnas.0610491104 http://dx.doi.org/10.1073/pnas.0610491104 DOI 10.1074/jbc.M709118200 http://dx.doi.org/10.1074/jbc.M709118200 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1101/gad.12.17.2770 http://dx.doi.org/10.1101/gad.12.17.2770 DOI 10.1107/S0907444910030015 http://dx.doi.org/10.1107/S0907444910030015 DOI 10.1111/j.1365-2958.2004.04329.x http://dx.doi.org/10.1111/j.1365-2958.2004.04329.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.1.11 {ECO:0000255|HAMAP-Rule:MF_00318} http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.11 {ECO:0000255|HAMAP-Rule:MF_00318} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M12843 http://www.ebi.ac.uk/ena/data/view/M12843 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29580 http://www.ebi.ac.uk/ena/data/view/U29580 EMBL X82400 http://www.ebi.ac.uk/ena/data/view/X82400 ENZYME 4.2.1.11 {ECO:0000255|HAMAP-Rule:MF_00318} http://enzyme.expasy.org/EC/4.2.1.11 {ECO:0000255|HAMAP-Rule:MF_00318} EchoBASE EB0254 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0254 EcoGene EG10258 http://www.ecogene.org/geneInfo.php?eg_id=EG10258 EnsemblBacteria AAC75821 http://www.ensemblgenomes.org/id/AAC75821 EnsemblBacteria AAC75821 http://www.ensemblgenomes.org/id/AAC75821 EnsemblBacteria BAE76853 http://www.ensemblgenomes.org/id/BAE76853 EnsemblBacteria BAE76853 http://www.ensemblgenomes.org/id/BAE76853 EnsemblBacteria BAE76853 http://www.ensemblgenomes.org/id/BAE76853 EnsemblBacteria b2779 http://www.ensemblgenomes.org/id/b2779 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0000015 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000015 GO_component GO:0005576 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005856 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005856 GO_component GO:0009986 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009986 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0004634 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004634 GO_process GO:0006096 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006096 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005576 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005856 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005856 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.20.20.120 http://www.cathdb.info/version/latest/superfamily/3.20.20.120 Gene3D 3.30.390.10 http://www.cathdb.info/version/latest/superfamily/3.30.390.10 GeneID 945032 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945032 HAMAP MF_00318 http://hamap.expasy.org/unirule/MF_00318 HOGENOM HOG000072173 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000072173&db=HOGENOM6 InParanoid P0A6P9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6P9 IntAct P0A6P9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6P9* IntEnz 4.2.1.11 {ECO:0000255|HAMAP-Rule:MF_00318} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.11 {ECO:0000255|HAMAP-Rule:MF_00318} InterPro IPR000941 http://www.ebi.ac.uk/interpro/entry/IPR000941 InterPro IPR020809 http://www.ebi.ac.uk/interpro/entry/IPR020809 InterPro IPR020810 http://www.ebi.ac.uk/interpro/entry/IPR020810 InterPro IPR020811 http://www.ebi.ac.uk/interpro/entry/IPR020811 InterPro IPR029017 http://www.ebi.ac.uk/interpro/entry/IPR029017 InterPro IPR029065 http://www.ebi.ac.uk/interpro/entry/IPR029065 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2750 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2750 KEGG_Gene eco:b2779 http://www.genome.jp/dbget-bin/www_bget?eco:b2779 KEGG_Orthology KO:K01689 http://www.genome.jp/dbget-bin/www_bget?KO:K01689 KEGG_Pathway ko00010 http://www.genome.jp/kegg-bin/show_pathway?ko00010 KEGG_Pathway ko00680 http://www.genome.jp/kegg-bin/show_pathway?ko00680 KEGG_Pathway ko03018 http://www.genome.jp/kegg-bin/show_pathway?ko03018 KEGG_Pathway ko04066 http://www.genome.jp/kegg-bin/show_pathway?ko04066 KEGG_Reaction rn:R00658 http://www.genome.jp/dbget-bin/www_bget?rn:R00658 MINT MINT-1230935 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1230935 OMA EFMIIPV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EFMIIPV PANTHER PTHR11902 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11902 PDB 1E9I http://www.ebi.ac.uk/pdbe-srv/view/entry/1E9I PDB 2FYM http://www.ebi.ac.uk/pdbe-srv/view/entry/2FYM PDB 3H8A http://www.ebi.ac.uk/pdbe-srv/view/entry/3H8A PDBsum 1E9I http://www.ebi.ac.uk/pdbsum/1E9I PDBsum 2FYM http://www.ebi.ac.uk/pdbsum/2FYM PDBsum 3H8A http://www.ebi.ac.uk/pdbsum/3H8A PRINTS PR00148 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00148 PROSITE PS00164 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00164 PSORT swissprot:ENO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ENO_ECOLI PSORT-B swissprot:ENO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ENO_ECOLI PSORT2 swissprot:ENO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ENO_ECOLI Pfam PF00113 http://pfam.xfam.org/family/PF00113 Pfam PF03952 http://pfam.xfam.org/family/PF03952 Phobius swissprot:ENO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ENO_ECOLI PhylomeDB P0A6P9 http://phylomedb.org/?seqid=P0A6P9 ProteinModelPortal P0A6P9 http://www.proteinmodelportal.org/query/uniprot/P0A6P9 PubMed 11676541 http://www.ncbi.nlm.nih.gov/pubmed/11676541 PubMed 14981237 http://www.ncbi.nlm.nih.gov/pubmed/14981237 PubMed 15003462 http://www.ncbi.nlm.nih.gov/pubmed/15003462 PubMed 15522087 http://www.ncbi.nlm.nih.gov/pubmed/15522087 PubMed 16516921 http://www.ncbi.nlm.nih.gov/pubmed/16516921 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17242352 http://www.ncbi.nlm.nih.gov/pubmed/17242352 PubMed 18337249 http://www.ncbi.nlm.nih.gov/pubmed/18337249 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 20823555 http://www.ncbi.nlm.nih.gov/pubmed/20823555 PubMed 2513001 http://www.ncbi.nlm.nih.gov/pubmed/2513001 PubMed 3514618 http://www.ncbi.nlm.nih.gov/pubmed/3514618 PubMed 4942326 http://www.ncbi.nlm.nih.gov/pubmed/4942326 PubMed 8610017 http://www.ncbi.nlm.nih.gov/pubmed/8610017 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 PubMed 9732274 http://www.ncbi.nlm.nih.gov/pubmed/9732274 RefSeq NP_417259 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417259 RefSeq WP_000036723 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000036723 SMART SM01192 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01192 SMART SM01193 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01193 SMR P0A6P9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6P9 STRING 511145.b2779 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2779&targetmode=cogs STRING COG0148 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0148&targetmode=cogs SUPFAM SSF51604 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51604 SUPFAM SSF54826 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54826 SWISS-2DPAGE P0A6P9 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A6P9 TIGRFAMs TIGR01060 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01060 UniProtKB ENO_ECOLI http://www.uniprot.org/uniprot/ENO_ECOLI UniProtKB-AC P0A6P9 http://www.uniprot.org/uniprot/P0A6P9 charge swissprot:ENO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ENO_ECOLI eggNOG COG0148 http://eggnogapi.embl.de/nog_data/html/tree/COG0148 eggNOG ENOG4105C70 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C70 epestfind swissprot:ENO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ENO_ECOLI garnier swissprot:ENO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ENO_ECOLI helixturnhelix swissprot:ENO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ENO_ECOLI hmoment swissprot:ENO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ENO_ECOLI iep swissprot:ENO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ENO_ECOLI inforesidue swissprot:ENO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ENO_ECOLI octanol swissprot:ENO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ENO_ECOLI pepcoil swissprot:ENO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ENO_ECOLI pepdigest swissprot:ENO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ENO_ECOLI pepinfo swissprot:ENO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ENO_ECOLI pepnet swissprot:ENO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ENO_ECOLI pepstats swissprot:ENO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ENO_ECOLI pepwheel swissprot:ENO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ENO_ECOLI pepwindow swissprot:ENO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ENO_ECOLI sigcleave swissprot:ENO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ENO_ECOLI ## Database ID URL or Descriptions # BioGrid 4261349 9 # EcoGene EG13809 lsrB # FUNCTION LSRB_ECOLI Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases (Probable). {ECO 0000305|PubMed 15601708}. # GO_component GO:0005886 plasma membrane; IBA:GO_Central. # GO_component GO:0016021 integral component of membrane; IBA:GO_Central. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IEA:InterPro. # GO_function GO:0015145 monosaccharide transmembrane transporter activity; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0022857 transmembrane transporter activity # INDUCTION LSRB_ECOLI In the absence of AI-2, repressed by LsrR. Induced by AI-2, via release of the LsrR repressor. In the absence of glucose, induced by cAMP-CRP by direct binding to the upstream region of the lsr promoter. {ECO 0000269|PubMed 15601708, ECO 0000269|PubMed 15743955}. # InterPro IPR025997 SBP_2_dom # InterPro IPR028082 Peripla_BP_I # InterPro IPR030159 LsrB/RhaS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00219 AI-2 transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism LSRB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR32196:SF1 PTHR32196:SF1 # PATRIC 32118328 VBIEscCol129921_1584 # PIR G64905 G64905 # Pfam PF13407 Peripla_BP_4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LSRB_ECOLI Autoinducer 2-binding protein LsrB # RefSeq NP_416033 NC_000913.3 # RefSeq WP_000172465 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial solute-binding protein 2 family. {ECO 0000305}. # SUBCELLULAR LOCATION LSRB_ECOLI Periplasm {ECO 0000305}. # SUBUNIT The complex is composed of two ATP-binding proteins (LsrA), two transmembrane proteins (LsrC and LsrD) and a solute- binding protein (LsrB). {ECO 0000305}. # SUPFAM SSF53822 SSF53822 # TCDB 3.A.1.2 the atp-binding cassette (abc) superfamily # eggNOG ENOG4105D4B Bacteria # eggNOG ENOG410XPHQ LUCA BLAST swissprot:LSRB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LSRB_ECOLI BioCyc ECOL316407:JW1509-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1509-MONOMER BioCyc EcoCyc:YNEA-MONOMER http://biocyc.org/getid?id=EcoCyc:YNEA-MONOMER BioCyc MetaCyc:YNEA-MONOMER http://biocyc.org/getid?id=MetaCyc:YNEA-MONOMER COG COG1879 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1879 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.187.1.238-248.2005 http://dx.doi.org/10.1128/JB.187.1.238-248.2005 DOI 10.1128/JB.187.6.2066-2076.2005 http://dx.doi.org/10.1128/JB.187.6.2066-2076.2005 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3570 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3570 EcoGene EG13809 http://www.ecogene.org/geneInfo.php?eg_id=EG13809 EnsemblBacteria AAC74589 http://www.ensemblgenomes.org/id/AAC74589 EnsemblBacteria AAC74589 http://www.ensemblgenomes.org/id/AAC74589 EnsemblBacteria BAE76456 http://www.ensemblgenomes.org/id/BAE76456 EnsemblBacteria BAE76456 http://www.ensemblgenomes.org/id/BAE76456 EnsemblBacteria BAE76456 http://www.ensemblgenomes.org/id/BAE76456 EnsemblBacteria b1516 http://www.ensemblgenomes.org/id/b1516 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0015145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015145 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GeneID 945418 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945418 HOGENOM HOG000092666 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000092666&db=HOGENOM6 InParanoid P76142 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76142 IntAct P76142 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76142* InterPro IPR025997 http://www.ebi.ac.uk/interpro/entry/IPR025997 InterPro IPR028082 http://www.ebi.ac.uk/interpro/entry/IPR028082 InterPro IPR030159 http://www.ebi.ac.uk/interpro/entry/IPR030159 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1509 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1509 KEGG_Gene eco:b1516 http://www.genome.jp/dbget-bin/www_bget?eco:b1516 KEGG_Orthology KO:K10555 http://www.genome.jp/dbget-bin/www_bget?KO:K10555 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA KKKYPNW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KKKYPNW PANTHER PTHR32196:SF1 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR32196:SF1 PSORT swissprot:LSRB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LSRB_ECOLI PSORT-B swissprot:LSRB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LSRB_ECOLI PSORT2 swissprot:LSRB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LSRB_ECOLI Pfam PF13407 http://pfam.xfam.org/family/PF13407 Phobius swissprot:LSRB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LSRB_ECOLI PhylomeDB P76142 http://phylomedb.org/?seqid=P76142 ProteinModelPortal P76142 http://www.proteinmodelportal.org/query/uniprot/P76142 PubMed 15601708 http://www.ncbi.nlm.nih.gov/pubmed/15601708 PubMed 15743955 http://www.ncbi.nlm.nih.gov/pubmed/15743955 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416033 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416033 RefSeq WP_000172465 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000172465 SMR P76142 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76142 STRING 511145.b1516 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1516&targetmode=cogs STRING COG1879 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1879&targetmode=cogs SUPFAM SSF53822 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53822 TCDB 3.A.1.2 http://www.tcdb.org/search/result.php?tc=3.A.1.2 UniProtKB LSRB_ECOLI http://www.uniprot.org/uniprot/LSRB_ECOLI UniProtKB-AC P76142 http://www.uniprot.org/uniprot/P76142 charge swissprot:LSRB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LSRB_ECOLI eggNOG ENOG4105D4B http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D4B eggNOG ENOG410XPHQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XPHQ epestfind swissprot:LSRB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LSRB_ECOLI garnier swissprot:LSRB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LSRB_ECOLI helixturnhelix swissprot:LSRB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LSRB_ECOLI hmoment swissprot:LSRB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LSRB_ECOLI iep swissprot:LSRB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LSRB_ECOLI inforesidue swissprot:LSRB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LSRB_ECOLI octanol swissprot:LSRB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LSRB_ECOLI pepcoil swissprot:LSRB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LSRB_ECOLI pepdigest swissprot:LSRB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LSRB_ECOLI pepinfo swissprot:LSRB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LSRB_ECOLI pepnet swissprot:LSRB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LSRB_ECOLI pepstats swissprot:LSRB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LSRB_ECOLI pepwheel swissprot:LSRB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LSRB_ECOLI pepwindow swissprot:LSRB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LSRB_ECOLI sigcleave swissprot:LSRB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LSRB_ECOLI ## Database ID URL or Descriptions # AltName Polynucleotide phosphorylase {ECO:0000255|HAMAP-Rule MF_01595} # BRENDA 2.7.7 2026 # BioGrid 4262431 8 # CATALYTIC ACTIVITY PNP_ECOLI RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate. {ECO 0000255|HAMAP-Rule MF_01595, ECO 0000269|PubMed 12162954, ECO 0000269|PubMed 18812438, ECO 0000269|PubMed 4866865}. # COFACTOR PNP_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_01595, ECO 0000269|PubMed 19327365}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000255|HAMAP-Rule MF_01595, ECO 0000269|PubMed 19327365}; Note=Magnesium. Can also use manganese. {ECO 0000255|HAMAP- Rule MF_01595, ECO 0000269|PubMed 19327365}; # DOMAIN PNP_ECOLI The S1 motif domain is important for trimerization and RNA-binding. {ECO 0000269|PubMed 18812438}. # EcoGene EG10743 pnp # FUNCTION PNP_ECOLI Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. Also involved, along with RNase II, in tRNA processing. {ECO 0000255|HAMAP-Rule MF_01595, ECO 0000269|PubMed 12162954, ECO 0000269|PubMed 18812438, ECO 0000269|PubMed 19327365, ECO 0000269|PubMed 4866865, ECO 0000269|PubMed 7509797}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0000175 3'-5'-exoribonuclease activity; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0003723 RNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0004654 polyribonucleotide nucleotidyltransferase activity; IDA:EcoCyc. # GO_function GO:0035438 cyclic-di-GMP binding; IDA:EcoCyc. # GO_process GO:0006396 RNA processing; IEA:InterPro. # GO_process GO:0006402 mRNA catabolic process; IEA:UniProtKB-HAMAP. # GO_process GO:0009408 response to heat; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0004518 nuclease activity # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # Gene3D 1.10.10.400 -; 1. # Gene3D 3.30.1370.10 -; 1. # Gene3D 3.30.230.70 -; 2. # HAMAP MF_01595 PNPase # INDUCTION PNP_ECOLI Expression is negatively autoregulated at the translational level via an RNase III-dependent mechanism. At low temperature, the destabilizing effect of PNPase on its own mRNA is less efficient, leading to a decrease in repression and an increase in the expression level. {ECO 0000269|PubMed 11395447, ECO 0000269|PubMed 1628624}. # INTERACTION PNP_ECOLI Self; NbExp=2; IntAct=EBI-548080, EBI-548080; P0A8J8 rhlB; NbExp=6; IntAct=EBI-548080, EBI-555806; P21513 rne; NbExp=11; IntAct=EBI-548080, EBI-549958; # IntAct P05055 45 # InterPro IPR001247 ExoRNase_PH_dom1 # InterPro IPR003029 S1_domain # InterPro IPR004087 KH_dom # InterPro IPR004088 KH_dom_type_1 # InterPro IPR012162 PNPase # InterPro IPR012340 NA-bd_OB-fold # InterPro IPR015847 ExoRNase_PH_dom2 # InterPro IPR015848 PNPase_PH_RNA-bd_bac/org-type # InterPro IPR020568 Ribosomal_S5_D2-typ_fold # InterPro IPR022967 S1_dom # InterPro IPR027408 PNPase/RNase_PH_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00240 Pyrimidine metabolism # KEGG_Pathway ko03018 RNA degradation # Organism PNP_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11252 PTHR11252 # PATRIC 32121746 VBIEscCol129921_3259 # PDB 1SRO NMR; -; A=617-692 # PDB 3CDI X-ray; 2.60 A; A=2-711 # PDB 3CDJ X-ray; 2.80 A; A=2-547 # PDB 3GCM X-ray; 2.50 A; A/B/C=1-549 # PDB 3GLL X-ray; 2.70 A; A=1-549 # PDB 3GME X-ray; 2.40 A; A=1-549 # PDB 3H1C X-ray; 3.57 A; A/B/C/G/I/K/M/O/R/T/V/X=1-549 # PIR H65106 H65106 # PIRSF PIRSF005499 PNPase # PROSITE PS50084 KH_TYPE_1 # PROSITE PS50126 S1 # Pfam PF00013 KH_1 # Pfam PF00575 S1 # Pfam PF01138 RNase_PH; 2 # Pfam PF03725 RNase_PH_C; 2 # Pfam PF03726 PNPase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Polyribonucleotide nucleotidyltransferase {ECO:0000255|HAMAP-Rule MF_01595} # RefSeq NP_417633 NC_000913.3 # RefSeq WP_001295554 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA57967.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAE77210.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the polyribonucleotide nucleotidyltransferase family. {ECO:0000255|HAMAP-Rule MF_01595}. # SIMILARITY Contains 1 KH domain. {ECO:0000255|HAMAP- Rule MF_01595}. # SIMILARITY Contains 1 S1 motif domain. {ECO:0000255|HAMAP- Rule MF_01595}. # SMART SM00316 S1 # SMART SM00322 KH # SUBCELLULAR LOCATION PNP_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_01595, ECO 0000269|PubMed 16079137}. Note=Has also been isolated in association with the inner membrane. # SUBUNIT PNP_ECOLI Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation. Interacts with RNase E (rne). Homotrimer. The homotrimer forms a ring-like structure with a central channel, where RNA molecules can bind. RNA molecules bind between neighboring subunits. {ECO 0000255|HAMAP-Rule MF_01595, ECO 0000269|PubMed 1089072, ECO 0000269|PubMed 15554978, ECO 0000269|PubMed 18337249, ECO 0000269|PubMed 18812438, ECO 0000269|PubMed 19327365, ECO 0000269|PubMed 9732274}. # SUPFAM SSF46915 SSF46915 # SUPFAM SSF50249 SSF50249 # SUPFAM SSF54211 SSF54211; 2 # SUPFAM SSF54791 SSF54791 # SUPFAM SSF55666 SSF55666; 2 # TIGRFAMs TIGR03591 polynuc_phos # eggNOG COG1185 LUCA # eggNOG ENOG4105C62 Bacteria BLAST swissprot:PNP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PNP_ECOLI BioCyc ECOL316407:JW5851-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5851-MONOMER BioCyc EcoCyc:EG10743-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10743-MONOMER BioCyc MetaCyc:EG10743-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10743-MONOMER COG COG1185 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1185 DIP DIP-10522N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10522N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1016/0014-5793(75)81045-3 http://dx.doi.org/10.1016/0014-5793(75)81045-3 DOI 10.1016/0378-1119(85)90019-8 http://dx.doi.org/10.1016/0378-1119(85)90019-8 DOI 10.1016/S0022-2836(02)00645-9 http://dx.doi.org/10.1016/S0022-2836(02)00645-9 DOI 10.1016/S0092-8674(00)81844-9 http://dx.doi.org/10.1016/S0092-8674(00)81844-9 DOI 10.1016/j.jmb.2009.03.051 http://dx.doi.org/10.1016/j.jmb.2009.03.051 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1074/jbc.M709118200 http://dx.doi.org/10.1074/jbc.M709118200 DOI 10.1093/nar/12.15.6091 http://dx.doi.org/10.1093/nar/12.15.6091 DOI 10.1101/gad.12.17.2770 http://dx.doi.org/10.1101/gad.12.17.2770 DOI 10.1111/j.1365-2958.2004.04360.x http://dx.doi.org/10.1111/j.1365-2958.2004.04360.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.183.13.3848-3854.2001 http://dx.doi.org/10.1128/JB.183.13.3848-3854.2001 DOI 10.1261/rna.1244308 http://dx.doi.org/10.1261/rna.1244308 EC_number EC:2.7.7.8 {ECO:0000255|HAMAP-Rule:MF_01595, ECO:0000269|PubMed:12162954, ECO:0000269|PubMed:18812438, ECO:0000269|PubMed:4866865} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.8 {ECO:0000255|HAMAP-Rule:MF_01595, ECO:0000269|PubMed:12162954, ECO:0000269|PubMed:18812438, ECO:0000269|PubMed:4866865} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J02638 http://www.ebi.ac.uk/ena/data/view/J02638 EMBL M14425 http://www.ebi.ac.uk/ena/data/view/M14425 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X00761 http://www.ebi.ac.uk/ena/data/view/X00761 ENZYME 2.7.7.8 {ECO:0000255|HAMAP-Rule:MF_01595, ECO:0000269|PubMed:12162954, ECO:0000269|PubMed:18812438, ECO:0000269|PubMed:4866865} http://enzyme.expasy.org/EC/2.7.7.8 {ECO:0000255|HAMAP-Rule:MF_01595, ECO:0000269|PubMed:12162954, ECO:0000269|PubMed:18812438, ECO:0000269|PubMed:4866865} EchoBASE EB0736 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0736 EcoGene EG10743 http://www.ecogene.org/geneInfo.php?eg_id=EG10743 EnsemblBacteria AAC76198 http://www.ensemblgenomes.org/id/AAC76198 EnsemblBacteria AAC76198 http://www.ensemblgenomes.org/id/AAC76198 EnsemblBacteria BAE77210 http://www.ensemblgenomes.org/id/BAE77210 EnsemblBacteria BAE77210 http://www.ensemblgenomes.org/id/BAE77210 EnsemblBacteria BAE77210 http://www.ensemblgenomes.org/id/BAE77210 EnsemblBacteria b3164 http://www.ensemblgenomes.org/id/b3164 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0000175 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000175 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0004654 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004654 GO_function GO:0035438 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035438 GO_process GO:0006396 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006396 GO_process GO:0006402 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006402 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 Gene3D 1.10.10.400 http://www.cathdb.info/version/latest/superfamily/1.10.10.400 Gene3D 3.30.1370.10 http://www.cathdb.info/version/latest/superfamily/3.30.1370.10 Gene3D 3.30.230.70 http://www.cathdb.info/version/latest/superfamily/3.30.230.70 GeneID 947672 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947672 HAMAP MF_01595 http://hamap.expasy.org/unirule/MF_01595 HOGENOM HOG000218327 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218327&db=HOGENOM6 InParanoid P05055 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P05055 IntAct P05055 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P05055* IntEnz 2.7.7.8 {ECO:0000255|HAMAP-Rule:MF_01595, ECO:0000269|PubMed:12162954, ECO:0000269|PubMed:18812438, ECO:0000269|PubMed:4866865} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.8 {ECO:0000255|HAMAP-Rule:MF_01595, ECO:0000269|PubMed:12162954, ECO:0000269|PubMed:18812438, ECO:0000269|PubMed:4866865} InterPro IPR001247 http://www.ebi.ac.uk/interpro/entry/IPR001247 InterPro IPR003029 http://www.ebi.ac.uk/interpro/entry/IPR003029 InterPro IPR004087 http://www.ebi.ac.uk/interpro/entry/IPR004087 InterPro IPR004088 http://www.ebi.ac.uk/interpro/entry/IPR004088 InterPro IPR012162 http://www.ebi.ac.uk/interpro/entry/IPR012162 InterPro IPR012340 http://www.ebi.ac.uk/interpro/entry/IPR012340 InterPro IPR015847 http://www.ebi.ac.uk/interpro/entry/IPR015847 InterPro IPR015848 http://www.ebi.ac.uk/interpro/entry/IPR015848 InterPro IPR020568 http://www.ebi.ac.uk/interpro/entry/IPR020568 InterPro IPR022967 http://www.ebi.ac.uk/interpro/entry/IPR022967 InterPro IPR027408 http://www.ebi.ac.uk/interpro/entry/IPR027408 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW5851 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5851 KEGG_Gene eco:b3164 http://www.genome.jp/dbget-bin/www_bget?eco:b3164 KEGG_Orthology KO:K00962 http://www.genome.jp/dbget-bin/www_bget?KO:K00962 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Pathway ko03018 http://www.genome.jp/kegg-bin/show_pathway?ko03018 KEGG_Reaction rn:R00437 http://www.genome.jp/dbget-bin/www_bget?rn:R00437 KEGG_Reaction rn:R00438 http://www.genome.jp/dbget-bin/www_bget?rn:R00438 KEGG_Reaction rn:R00439 http://www.genome.jp/dbget-bin/www_bget?rn:R00439 KEGG_Reaction rn:R00440 http://www.genome.jp/dbget-bin/www_bget?rn:R00440 MINT MINT-244786 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-244786 OMA RFMFHYN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RFMFHYN PANTHER PTHR11252 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11252 PDB 1SRO http://www.ebi.ac.uk/pdbe-srv/view/entry/1SRO PDB 3CDI http://www.ebi.ac.uk/pdbe-srv/view/entry/3CDI PDB 3CDJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3CDJ PDB 3GCM http://www.ebi.ac.uk/pdbe-srv/view/entry/3GCM PDB 3GLL http://www.ebi.ac.uk/pdbe-srv/view/entry/3GLL PDB 3GME http://www.ebi.ac.uk/pdbe-srv/view/entry/3GME PDB 3H1C http://www.ebi.ac.uk/pdbe-srv/view/entry/3H1C PDBsum 1SRO http://www.ebi.ac.uk/pdbsum/1SRO PDBsum 3CDI http://www.ebi.ac.uk/pdbsum/3CDI PDBsum 3CDJ http://www.ebi.ac.uk/pdbsum/3CDJ PDBsum 3GCM http://www.ebi.ac.uk/pdbsum/3GCM PDBsum 3GLL http://www.ebi.ac.uk/pdbsum/3GLL PDBsum 3GME http://www.ebi.ac.uk/pdbsum/3GME PDBsum 3H1C http://www.ebi.ac.uk/pdbsum/3H1C PROSITE PS50084 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50084 PROSITE PS50126 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50126 PSORT swissprot:PNP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PNP_ECOLI PSORT-B swissprot:PNP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PNP_ECOLI PSORT2 swissprot:PNP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PNP_ECOLI Pfam PF00013 http://pfam.xfam.org/family/PF00013 Pfam PF00575 http://pfam.xfam.org/family/PF00575 Pfam PF01138 http://pfam.xfam.org/family/PF01138 Pfam PF03725 http://pfam.xfam.org/family/PF03725 Pfam PF03726 http://pfam.xfam.org/family/PF03726 Phobius swissprot:PNP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PNP_ECOLI PhylomeDB P05055 http://phylomedb.org/?seqid=P05055 ProteinModelPortal P05055 http://www.proteinmodelportal.org/query/uniprot/P05055 PubMed 1089072 http://www.ncbi.nlm.nih.gov/pubmed/1089072 PubMed 11395447 http://www.ncbi.nlm.nih.gov/pubmed/11395447 PubMed 12162954 http://www.ncbi.nlm.nih.gov/pubmed/12162954 PubMed 15554978 http://www.ncbi.nlm.nih.gov/pubmed/15554978 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 1628624 http://www.ncbi.nlm.nih.gov/pubmed/1628624 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18337249 http://www.ncbi.nlm.nih.gov/pubmed/18337249 PubMed 18812438 http://www.ncbi.nlm.nih.gov/pubmed/18812438 PubMed 19327365 http://www.ncbi.nlm.nih.gov/pubmed/19327365 PubMed 2432069 http://www.ncbi.nlm.nih.gov/pubmed/2432069 PubMed 3005122 http://www.ncbi.nlm.nih.gov/pubmed/3005122 PubMed 4866865 http://www.ncbi.nlm.nih.gov/pubmed/4866865 PubMed 6382163 http://www.ncbi.nlm.nih.gov/pubmed/6382163 PubMed 7509797 http://www.ncbi.nlm.nih.gov/pubmed/7509797 PubMed 9008164 http://www.ncbi.nlm.nih.gov/pubmed/9008164 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9732274 http://www.ncbi.nlm.nih.gov/pubmed/9732274 RefSeq NP_417633 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417633 RefSeq WP_001295554 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295554 SMART SM00316 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00316 SMART SM00322 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00322 SMR P05055 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P05055 STRING 511145.b3164 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3164&targetmode=cogs STRING COG1185 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1185&targetmode=cogs SUPFAM SSF46915 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46915 SUPFAM SSF50249 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50249 SUPFAM SSF54211 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54211 SUPFAM SSF54791 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54791 SUPFAM SSF55666 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55666 SWISS-2DPAGE P05055 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P05055 TIGRFAMs TIGR03591 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03591 UniProtKB PNP_ECOLI http://www.uniprot.org/uniprot/PNP_ECOLI UniProtKB-AC P05055 http://www.uniprot.org/uniprot/P05055 charge swissprot:PNP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PNP_ECOLI eggNOG COG1185 http://eggnogapi.embl.de/nog_data/html/tree/COG1185 eggNOG ENOG4105C62 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C62 epestfind swissprot:PNP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PNP_ECOLI garnier swissprot:PNP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PNP_ECOLI helixturnhelix swissprot:PNP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PNP_ECOLI hmoment swissprot:PNP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PNP_ECOLI iep swissprot:PNP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PNP_ECOLI inforesidue swissprot:PNP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PNP_ECOLI octanol swissprot:PNP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PNP_ECOLI pepcoil swissprot:PNP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PNP_ECOLI pepdigest swissprot:PNP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PNP_ECOLI pepinfo swissprot:PNP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PNP_ECOLI pepnet swissprot:PNP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PNP_ECOLI pepstats swissprot:PNP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PNP_ECOLI pepwheel swissprot:PNP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PNP_ECOLI pepwindow swissprot:PNP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PNP_ECOLI sigcleave swissprot:PNP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PNP_ECOLI ## Database ID URL or Descriptions # BioGrid 4262718 170 # EcoGene EG12504 cycA # FUNCTION CYCA_ECOLI Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0001761 beta-alanine transmembrane transporter activity; IMP:EcoCyc. # GO_function GO:0015180 L-alanine transmembrane transporter activity; IMP:EcoCyc. # GO_function GO:0015187 glycine transmembrane transporter activity; IMP:EcoCyc. # GO_function GO:0015297 antiporter activity; IBA:GO_Central. # GO_function GO:0042895 antibiotic transporter activity; IMP:EcoCyc. # GO_function GO:0042944 D-alanine transmembrane transporter activity; IMP:EcoCyc. # GO_function GO:0042945 D-serine transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0001762 beta-alanine transport; IMP:EcoCyc. # GO_process GO:0015808 L-alanine transport; IMP:EcoCyc. # GO_process GO:0015816 glycine transport; IMP:EcoCyc. # GO_process GO:0042891 antibiotic transport; IMP:EcoCyc. # GO_process GO:0042941 D-alanine transport; IMP:EcoCyc. # GO_process GO:0042942 D-serine transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR002293 AA/rel_permease1 # InterPro IPR004840 Amoino_acid_permease_CS # InterPro IPR004841 AA-permease/SLC12A_dom # KEGG_Brite ko02000 Transporters # Organism CYCA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11785 PTHR11785 # PATRIC 32123991 VBIEscCol129921_4340 # PIR S56433 S56433 # PIRSF PIRSF006060 AA_transporter # PROSITE PS00218 AMINO_ACID_PERMEASE_1 # Pfam PF00324 AA_permease # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CYCA_ECOLI D-serine/D-alanine/glycine transporter # RefSeq NP_418629 NC_000913.3 # RefSeq WP_000228346 NZ_LN832404.1 # SIMILARITY Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family. {ECO 0000305}. # SUBCELLULAR LOCATION CYCA_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.3.1 the amino acid-polyamine-organocation (apc) family # eggNOG COG1113 LUCA # eggNOG ENOG4105C85 Bacteria BLAST swissprot:CYCA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CYCA_ECOLI BioCyc ECOL316407:JW4166-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4166-MONOMER BioCyc EcoCyc:CYCA-MONOMER http://biocyc.org/getid?id=EcoCyc:CYCA-MONOMER BioCyc MetaCyc:CYCA-MONOMER http://biocyc.org/getid?id=MetaCyc:CYCA-MONOMER COG COG1113 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1113 DIP DIP-9359N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9359N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2397 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2397 EcoGene EG12504 http://www.ecogene.org/geneInfo.php?eg_id=EG12504 EnsemblBacteria AAC77165 http://www.ensemblgenomes.org/id/AAC77165 EnsemblBacteria AAC77165 http://www.ensemblgenomes.org/id/AAC77165 EnsemblBacteria BAE78209 http://www.ensemblgenomes.org/id/BAE78209 EnsemblBacteria BAE78209 http://www.ensemblgenomes.org/id/BAE78209 EnsemblBacteria BAE78209 http://www.ensemblgenomes.org/id/BAE78209 EnsemblBacteria b4208 http://www.ensemblgenomes.org/id/b4208 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0001761 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001761 GO_function GO:0015180 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015180 GO_function GO:0015187 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015187 GO_function GO:0015297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015297 GO_function GO:0042895 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042895 GO_function GO:0042944 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042944 GO_function GO:0042945 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042945 GO_process GO:0001762 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001762 GO_process GO:0015808 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015808 GO_process GO:0015816 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015816 GO_process GO:0042891 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042891 GO_process GO:0042941 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042941 GO_process GO:0042942 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042942 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948725 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948725 HOGENOM HOG000261849 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261849&db=HOGENOM6 InParanoid P0AAE0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAE0 IntAct P0AAE0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAE0* InterPro IPR002293 http://www.ebi.ac.uk/interpro/entry/IPR002293 InterPro IPR004840 http://www.ebi.ac.uk/interpro/entry/IPR004840 InterPro IPR004841 http://www.ebi.ac.uk/interpro/entry/IPR004841 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW4166 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4166 KEGG_Gene eco:b4208 http://www.genome.jp/dbget-bin/www_bget?eco:b4208 KEGG_Orthology KO:K11737 http://www.genome.jp/dbget-bin/www_bget?KO:K11737 MINT MINT-1286142 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1286142 OMA LCWIITG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LCWIITG PANTHER PTHR11785 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11785 PROSITE PS00218 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00218 PSORT swissprot:CYCA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CYCA_ECOLI PSORT-B swissprot:CYCA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CYCA_ECOLI PSORT2 swissprot:CYCA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CYCA_ECOLI Pfam PF00324 http://pfam.xfam.org/family/PF00324 Phobius swissprot:CYCA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CYCA_ECOLI PhylomeDB P0AAE0 http://phylomedb.org/?seqid=P0AAE0 ProteinModelPortal P0AAE0 http://www.proteinmodelportal.org/query/uniprot/P0AAE0 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418629 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418629 RefSeq WP_000228346 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000228346 STRING 511145.b4208 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4208&targetmode=cogs STRING COG1113 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1113&targetmode=cogs TCDB 2.A.3.1 http://www.tcdb.org/search/result.php?tc=2.A.3.1 UniProtKB CYCA_ECOLI http://www.uniprot.org/uniprot/CYCA_ECOLI UniProtKB-AC P0AAE0 http://www.uniprot.org/uniprot/P0AAE0 charge swissprot:CYCA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CYCA_ECOLI eggNOG COG1113 http://eggnogapi.embl.de/nog_data/html/tree/COG1113 eggNOG ENOG4105C85 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C85 epestfind swissprot:CYCA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CYCA_ECOLI garnier swissprot:CYCA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CYCA_ECOLI helixturnhelix swissprot:CYCA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CYCA_ECOLI hmoment swissprot:CYCA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CYCA_ECOLI iep swissprot:CYCA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CYCA_ECOLI inforesidue swissprot:CYCA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CYCA_ECOLI octanol swissprot:CYCA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CYCA_ECOLI pepcoil swissprot:CYCA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CYCA_ECOLI pepdigest swissprot:CYCA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CYCA_ECOLI pepinfo swissprot:CYCA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CYCA_ECOLI pepnet swissprot:CYCA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CYCA_ECOLI pepstats swissprot:CYCA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CYCA_ECOLI pepwheel swissprot:CYCA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CYCA_ECOLI pepwindow swissprot:CYCA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CYCA_ECOLI sigcleave swissprot:CYCA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CYCA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262548 5 # CAUTION Was originally proposed to be a subunit from an L- xylulose uptake system, but PubMed:16385129 shows that it does not bind L- or D-xylulose. {ECO 0000305|PubMed:14668138}. # EcoGene EG12281 yiaM # FUNCTION YIAM_ECOLI Part of the tripartite ATP-independent periplasmic (TRAP) transport system YiaMNO involved in the uptake of 2,3- diketo-L-gulonate. {ECO 0000269|PubMed 16385129}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015144 carbohydrate transmembrane transporter activity; IDA:EcoCyc. # GO_process GO:0034219 carbohydrate transmembrane transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0055085 transmembrane transport # InterPro IPR007387 DctQ_transporter # Organism YIAM_ECOLI Escherichia coli (strain K12) # PATRIC 32122630 VBIEscCol129921_3692 # PIR S47798 S47798 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF04290 DctQ # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIAM_ECOLI 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM # RefSeq NP_418034 NC_000913.3 # RefSeq WP_000721664 NZ_LN832404.1 # SIMILARITY Belongs to the TRAP transporter small permease family. {ECO 0000305}. # SUBCELLULAR LOCATION YIAM_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT YIAM_ECOLI The complex comprises the extracytoplasmic solute receptor protein YiaO, and the two transmembrane proteins YiaM and YiaN. # TCDB 2.A.56.1 the tripartite atp-independent periplasmic transporter (trap-t) family # eggNOG COG3090 LUCA # eggNOG ENOG4105XDZ Bacteria BLAST swissprot:YIAM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIAM_ECOLI BioCyc ECOL316407:JW3549-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3549-MONOMER BioCyc EcoCyc:MONOMER0-422 http://biocyc.org/getid?id=EcoCyc:MONOMER0-422 BioCyc MetaCyc:MONOMER0-422 http://biocyc.org/getid?id=MetaCyc:MONOMER0-422 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1080/09687680310001607369 http://dx.doi.org/10.1080/09687680310001607369 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1099/mic.0.27851-0 http://dx.doi.org/10.1099/mic.0.27851-0 DOI 10.1099/mic.0.28334-0 http://dx.doi.org/10.1099/mic.0.28334-0 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2189 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2189 EcoGene EG12281 http://www.ecogene.org/geneInfo.php?eg_id=EG12281 EnsemblBacteria AAC76601 http://www.ensemblgenomes.org/id/AAC76601 EnsemblBacteria AAC76601 http://www.ensemblgenomes.org/id/AAC76601 EnsemblBacteria BAE77716 http://www.ensemblgenomes.org/id/BAE77716 EnsemblBacteria BAE77716 http://www.ensemblgenomes.org/id/BAE77716 EnsemblBacteria BAE77716 http://www.ensemblgenomes.org/id/BAE77716 EnsemblBacteria b3577 http://www.ensemblgenomes.org/id/b3577 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015144 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015144 GO_process GO:0034219 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034219 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 948093 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948093 HOGENOM HOG000224991 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000224991&db=HOGENOM6 InParanoid P37674 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37674 InterPro IPR007387 http://www.ebi.ac.uk/interpro/entry/IPR007387 KEGG_Gene ecj:JW3549 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3549 KEGG_Gene eco:b3577 http://www.genome.jp/dbget-bin/www_bget?eco:b3577 OMA MLFCCYL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MLFCCYL PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YIAM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIAM_ECOLI PSORT-B swissprot:YIAM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIAM_ECOLI PSORT2 swissprot:YIAM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIAM_ECOLI Pfam PF04290 http://pfam.xfam.org/family/PF04290 Phobius swissprot:YIAM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIAM_ECOLI PhylomeDB P37674 http://phylomedb.org/?seqid=P37674 ProteinModelPortal P37674 http://www.proteinmodelportal.org/query/uniprot/P37674 PubMed 14668138 http://www.ncbi.nlm.nih.gov/pubmed/14668138 PubMed 15870475 http://www.ncbi.nlm.nih.gov/pubmed/15870475 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16385129 http://www.ncbi.nlm.nih.gov/pubmed/16385129 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418034 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418034 RefSeq WP_000721664 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000721664 STRING 511145.b3577 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3577&targetmode=cogs TCDB 2.A.56.1 http://www.tcdb.org/search/result.php?tc=2.A.56.1 UniProtKB YIAM_ECOLI http://www.uniprot.org/uniprot/YIAM_ECOLI UniProtKB-AC P37674 http://www.uniprot.org/uniprot/P37674 charge swissprot:YIAM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIAM_ECOLI eggNOG COG3090 http://eggnogapi.embl.de/nog_data/html/tree/COG3090 eggNOG ENOG4105XDZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105XDZ epestfind swissprot:YIAM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIAM_ECOLI garnier swissprot:YIAM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIAM_ECOLI helixturnhelix swissprot:YIAM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIAM_ECOLI hmoment swissprot:YIAM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIAM_ECOLI iep swissprot:YIAM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIAM_ECOLI inforesidue swissprot:YIAM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIAM_ECOLI octanol swissprot:YIAM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIAM_ECOLI pepcoil swissprot:YIAM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIAM_ECOLI pepdigest swissprot:YIAM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIAM_ECOLI pepinfo swissprot:YIAM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIAM_ECOLI pepnet swissprot:YIAM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIAM_ECOLI pepstats swissprot:YIAM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIAM_ECOLI pepwheel swissprot:YIAM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIAM_ECOLI pepwindow swissprot:YIAM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIAM_ECOLI sigcleave swissprot:YIAM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIAM_ECOLI ## Database ID URL or Descriptions # AltName LEP_ECOLI Leader peptidase I # BRENDA 3.4.21.89 2026 # BioGrid 4259467 97 # CATALYTIC ACTIVITY LEP_ECOLI Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins. # EcoGene EG10530 lepB # GO_component GO:0005886 plasma membrane; IDA:EcoliWiki. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IDA:EcoliWiki. # GO_function GO:0004175 endopeptidase activity; IDA:EcoCyc. # GO_function GO:0004252 serine-type endopeptidase activity; IMP:EcoCyc. # GO_function GO:0008233 peptidase activity; IDA:EcoliWiki. # GO_function GO:0015643 toxic substance binding; IMP:EcoliWiki. # GO_process GO:0006465 signal peptide processing; IDA:EcoCyc. # GO_process GO:0006508 proteolysis; IDA:EcoliWiki. # GO_process GO:0016485 protein processing; IMP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008233 peptidase activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0051604 protein maturation # Gene3D 2.10.109.10 -; 2. # Gene3D 2.170.230.10 -; 1. # InterPro IPR000223 Pept_S26A_signal_pept_1 # InterPro IPR015927 Peptidase_S24_S26A/B/C # InterPro IPR019533 Peptidase_S26 # InterPro IPR019756 Pept_S26A_signal_pept_1_Ser-AS # InterPro IPR019757 Pept_S26A_signal_pept_1_Lys-AS # InterPro IPR019758 Pept_S26A_signal_pept_1_CS # InterPro IPR019759 Peptidase_S24_S26 # InterPro IPR019766 Peptidase_S26A_all-beta_subdom # InterPro IPR028360 Peptidase_S24/S26_b-rbn # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # KEGG_Pathway ko03060 Protein export # Organism LEP_ECOLI Escherichia coli (strain K12) # PANTHER PTHR12383 PTHR12383; 2 # PATRIC 32120535 VBIEscCol129921_2670 # PDB 1B12 X-ray; 1.95 A; A/B/C/D=77-324 # PDB 1KN9 X-ray; 2.40 A; A/B/C/D=77-324 # PDB 1T7D X-ray; 2.47 A; A/B=76-324 # PDB 3IIQ X-ray; 2.00 A; A/B=77-324 # PDB 3S04 X-ray; 2.44 A; A/B=76-324 # PIR G65034 ZPECS # PRINTS PR00727 LEADERPTASE # PROSITE PS00501 SPASE_I_1 # PROSITE PS00760 SPASE_I_2 # PROSITE PS00761 SPASE_I_3 # Pfam PF00717 Peptidase_S24 # Pfam PF10502 Peptidase_S26 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LEP_ECOLI Signal peptidase I # RefSeq NP_417063 NC_000913.3 # RefSeq WP_000002541 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase S26 family. {ECO 0000305}. # SUBCELLULAR LOCATION LEP_ECOLI Cell inner membrane {ECO 0000269|PubMed 21778229}; Multi-pass membrane protein {ECO 0000269|PubMed 21778229}. # SUPFAM SSF51306 SSF51306 # TIGRFAMs TIGR02227 sigpep_I_bact # eggNOG COG0681 LUCA # eggNOG ENOG4105C3F Bacteria BLAST swissprot:LEP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LEP_ECOLI BioCyc ECOL316407:JW2552-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2552-MONOMER BioCyc EcoCyc:EG10530-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10530-MONOMER BioCyc MetaCyc:EG10530-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10530-MONOMER COG COG0681 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0681 DOI 10.1038/24196 http://dx.doi.org/10.1038/24196 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2820539 http://dx.doi.org/10.1042/bj2820539 DOI 10.1074/jbc.M111.245696 http://dx.doi.org/10.1074/jbc.M111.245696 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.21.89 http://www.genome.jp/dbget-bin/www_bget?EC:3.4.21.89 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D64044 http://www.ebi.ac.uk/ena/data/view/D64044 EMBL K00426 http://www.ebi.ac.uk/ena/data/view/K00426 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.4.21.89 http://enzyme.expasy.org/EC/3.4.21.89 EchoBASE EB0525 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0525 EcoGene EG10530 http://www.ecogene.org/geneInfo.php?eg_id=EG10530 EnsemblBacteria AAC75621 http://www.ensemblgenomes.org/id/AAC75621 EnsemblBacteria AAC75621 http://www.ensemblgenomes.org/id/AAC75621 EnsemblBacteria BAE76744 http://www.ensemblgenomes.org/id/BAE76744 EnsemblBacteria BAE76744 http://www.ensemblgenomes.org/id/BAE76744 EnsemblBacteria BAE76744 http://www.ensemblgenomes.org/id/BAE76744 EnsemblBacteria b2568 http://www.ensemblgenomes.org/id/b2568 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0004175 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004175 GO_function GO:0004252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004252 GO_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GO_function GO:0015643 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015643 GO_process GO:0006465 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006465 GO_process GO:0006508 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006508 GO_process GO:0016485 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016485 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 Gene3D 2.10.109.10 http://www.cathdb.info/version/latest/superfamily/2.10.109.10 Gene3D 2.170.230.10 http://www.cathdb.info/version/latest/superfamily/2.170.230.10 GeneID 947040 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947040 HOGENOM HOG000003674 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000003674&db=HOGENOM6 InParanoid P00803 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00803 IntEnz 3.4.21.89 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.21.89 InterPro IPR000223 http://www.ebi.ac.uk/interpro/entry/IPR000223 InterPro IPR015927 http://www.ebi.ac.uk/interpro/entry/IPR015927 InterPro IPR019533 http://www.ebi.ac.uk/interpro/entry/IPR019533 InterPro IPR019756 http://www.ebi.ac.uk/interpro/entry/IPR019756 InterPro IPR019757 http://www.ebi.ac.uk/interpro/entry/IPR019757 InterPro IPR019758 http://www.ebi.ac.uk/interpro/entry/IPR019758 InterPro IPR019759 http://www.ebi.ac.uk/interpro/entry/IPR019759 InterPro IPR019766 http://www.ebi.ac.uk/interpro/entry/IPR019766 InterPro IPR028360 http://www.ebi.ac.uk/interpro/entry/IPR028360 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW2552 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2552 KEGG_Gene eco:b2568 http://www.genome.jp/dbget-bin/www_bget?eco:b2568 KEGG_Orthology KO:K03100 http://www.genome.jp/dbget-bin/www_bget?KO:K03100 KEGG_Pathway ko03060 http://www.genome.jp/kegg-bin/show_pathway?ko03060 OMA FKWAPAR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FKWAPAR PANTHER PTHR12383 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12383 PDB 1B12 http://www.ebi.ac.uk/pdbe-srv/view/entry/1B12 PDB 1KN9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1KN9 PDB 1T7D http://www.ebi.ac.uk/pdbe-srv/view/entry/1T7D PDB 3IIQ http://www.ebi.ac.uk/pdbe-srv/view/entry/3IIQ PDB 3S04 http://www.ebi.ac.uk/pdbe-srv/view/entry/3S04 PDBsum 1B12 http://www.ebi.ac.uk/pdbsum/1B12 PDBsum 1KN9 http://www.ebi.ac.uk/pdbsum/1KN9 PDBsum 1T7D http://www.ebi.ac.uk/pdbsum/1T7D PDBsum 3IIQ http://www.ebi.ac.uk/pdbsum/3IIQ PDBsum 3S04 http://www.ebi.ac.uk/pdbsum/3S04 PRINTS PR00727 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00727 PROSITE PS00501 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00501 PROSITE PS00760 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00760 PROSITE PS00761 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00761 PSORT swissprot:LEP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LEP_ECOLI PSORT-B swissprot:LEP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LEP_ECOLI PSORT2 swissprot:LEP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LEP_ECOLI Pfam PF00717 http://pfam.xfam.org/family/PF00717 Pfam PF10502 http://pfam.xfam.org/family/PF10502 Phobius swissprot:LEP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LEP_ECOLI PhylomeDB P00803 http://phylomedb.org/?seqid=P00803 ProteinModelPortal P00803 http://www.proteinmodelportal.org/query/uniprot/P00803 PubMed 1546969 http://www.ncbi.nlm.nih.gov/pubmed/1546969 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 1618816 http://www.ncbi.nlm.nih.gov/pubmed/1618816 PubMed 16453726 http://www.ncbi.nlm.nih.gov/pubmed/16453726 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21778229 http://www.ncbi.nlm.nih.gov/pubmed/21778229 PubMed 2202591 http://www.ncbi.nlm.nih.gov/pubmed/2202591 PubMed 2551889 http://www.ncbi.nlm.nih.gov/pubmed/2551889 PubMed 6311837 http://www.ncbi.nlm.nih.gov/pubmed/6311837 PubMed 8394311 http://www.ncbi.nlm.nih.gov/pubmed/8394311 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9823901 http://www.ncbi.nlm.nih.gov/pubmed/9823901 RefSeq NP_417063 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417063 RefSeq WP_000002541 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000002541 SMR P00803 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00803 STRING 511145.b2568 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2568&targetmode=cogs STRING COG0681 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0681&targetmode=cogs SUPFAM SSF51306 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51306 TIGRFAMs TIGR02227 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02227 UniProtKB LEP_ECOLI http://www.uniprot.org/uniprot/LEP_ECOLI UniProtKB-AC P00803 http://www.uniprot.org/uniprot/P00803 charge swissprot:LEP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LEP_ECOLI eggNOG COG0681 http://eggnogapi.embl.de/nog_data/html/tree/COG0681 eggNOG ENOG4105C3F http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C3F epestfind swissprot:LEP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LEP_ECOLI garnier swissprot:LEP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LEP_ECOLI helixturnhelix swissprot:LEP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LEP_ECOLI hmoment swissprot:LEP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LEP_ECOLI iep swissprot:LEP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LEP_ECOLI inforesidue swissprot:LEP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LEP_ECOLI octanol swissprot:LEP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LEP_ECOLI pepcoil swissprot:LEP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LEP_ECOLI pepdigest swissprot:LEP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LEP_ECOLI pepinfo swissprot:LEP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LEP_ECOLI pepnet swissprot:LEP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LEP_ECOLI pepstats swissprot:LEP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LEP_ECOLI pepwheel swissprot:LEP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LEP_ECOLI pepwindow swissprot:LEP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LEP_ECOLI sigcleave swissprot:LEP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LEP_ECOLI ## Database ID URL or Descriptions # BioGrid 4260679 231 # EcoGene EG11592 ybeD # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # Gene3D 3.30.70.1460 -; 1. # HAMAP MF_00659 UPF0250 # INTERACTION YBED_ECOLI P0CE47 tufA; NbExp=2; IntAct=EBI-370708, EBI-301077; # IntAct P0A8J4 9 # InterPro IPR007454 UPF0250 # InterPro IPR027471 YbeD-like # Organism YBED_ECOLI Escherichia coli (strain K12) # PATRIC 32116443 VBIEscCol129921_0661 # PDB 1RWU NMR; -; A=1-87 # PIR E64797 E64797 # Pfam PF04359 DUF493 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBED_ECOLI UPF0250 protein YbeD # RefSeq NP_415164 NC_000913.3 # RefSeq WP_000850550 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0250 family. {ECO 0000305}. # SUPFAM SSF117991 SSF117991 # eggNOG COG2921 LUCA # eggNOG ENOG4108Z43 Bacteria BLAST swissprot:YBED_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBED_ECOLI BioCyc ECOL316407:JW0626-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0626-MONOMER BioCyc EcoCyc:EG11592-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11592-MONOMER COG COG2921 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2921 DIP DIP-31839N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31839N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.186.23.8083-8088.2004 http://dx.doi.org/10.1128/JB.186.23.8083-8088.2004 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L07636 http://www.ebi.ac.uk/ena/data/view/L07636 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB1550 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1550 EcoGene EG11592 http://www.ecogene.org/geneInfo.php?eg_id=EG11592 EnsemblBacteria AAC73732 http://www.ensemblgenomes.org/id/AAC73732 EnsemblBacteria AAC73732 http://www.ensemblgenomes.org/id/AAC73732 EnsemblBacteria BAA35274 http://www.ensemblgenomes.org/id/BAA35274 EnsemblBacteria BAA35274 http://www.ensemblgenomes.org/id/BAA35274 EnsemblBacteria BAA35274 http://www.ensemblgenomes.org/id/BAA35274 EnsemblBacteria b0631 http://www.ensemblgenomes.org/id/b0631 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 Gene3D 3.30.70.1460 http://www.cathdb.info/version/latest/superfamily/3.30.70.1460 GeneID 945220 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945220 HAMAP MF_00659 http://hamap.expasy.org/unirule/MF_00659 HOGENOM HOG000265101 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000265101&db=HOGENOM6 InParanoid P0A8J4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8J4 IntAct P0A8J4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8J4* InterPro IPR007454 http://www.ebi.ac.uk/interpro/entry/IPR007454 InterPro IPR027471 http://www.ebi.ac.uk/interpro/entry/IPR027471 KEGG_Gene ecj:JW0626 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0626 KEGG_Gene eco:b0631 http://www.genome.jp/dbget-bin/www_bget?eco:b0631 KEGG_Orthology KO:K09158 http://www.genome.jp/dbget-bin/www_bget?KO:K09158 MINT MINT-1273776 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1273776 OMA DYSPQVK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DYSPQVK PDB 1RWU http://www.ebi.ac.uk/pdbe-srv/view/entry/1RWU PDBsum 1RWU http://www.ebi.ac.uk/pdbsum/1RWU PSORT swissprot:YBED_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBED_ECOLI PSORT-B swissprot:YBED_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBED_ECOLI PSORT2 swissprot:YBED_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBED_ECOLI Pfam PF04359 http://pfam.xfam.org/family/PF04359 Phobius swissprot:YBED_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBED_ECOLI PhylomeDB P0A8J4 http://phylomedb.org/?seqid=P0A8J4 ProteinModelPortal P0A8J4 http://www.proteinmodelportal.org/query/uniprot/P0A8J4 PubMed 15547281 http://www.ncbi.nlm.nih.gov/pubmed/15547281 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8444795 http://www.ncbi.nlm.nih.gov/pubmed/8444795 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415164 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415164 RefSeq WP_000850550 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000850550 SMR P0A8J4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8J4 STRING 511145.b0631 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0631&targetmode=cogs STRING COG2921 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2921&targetmode=cogs SUPFAM SSF117991 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF117991 UniProtKB YBED_ECOLI http://www.uniprot.org/uniprot/YBED_ECOLI UniProtKB-AC P0A8J4 http://www.uniprot.org/uniprot/P0A8J4 charge swissprot:YBED_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBED_ECOLI eggNOG COG2921 http://eggnogapi.embl.de/nog_data/html/tree/COG2921 eggNOG ENOG4108Z43 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Z43 epestfind swissprot:YBED_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBED_ECOLI garnier swissprot:YBED_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBED_ECOLI helixturnhelix swissprot:YBED_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBED_ECOLI hmoment swissprot:YBED_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBED_ECOLI iep swissprot:YBED_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBED_ECOLI inforesidue swissprot:YBED_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBED_ECOLI octanol swissprot:YBED_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBED_ECOLI pepcoil swissprot:YBED_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBED_ECOLI pepdigest swissprot:YBED_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBED_ECOLI pepinfo swissprot:YBED_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBED_ECOLI pepnet swissprot:YBED_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBED_ECOLI pepstats swissprot:YBED_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBED_ECOLI pepwheel swissprot:YBED_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBED_ECOLI pepwindow swissprot:YBED_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBED_ECOLI sigcleave swissprot:YBED_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBED_ECOLI ## Database ID URL or Descriptions # AltName RNG_ECOLI Cytoplasmic axial filament protein # BRENDA 3.1.26 2165 # BioGrid 4262071 182 # COFACTOR RNG_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250}; Note=Binds 1 Mg(2+) ion per subunit. {ECO 0000250}; # EcoGene EG11299 rng # FUNCTION RNG_ECOLI Involved in the processing of the 5'-end of 16S rRNA. Could be involved in chromosome segregation and cell division. It may be one of the components of the cytoplasmic axial filaments bundles or merely regulate the formation of this structure. {ECO 0000269|PubMed 10362534}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_component GO:0005856 cytoskeleton; IEA:UniProtKB-SubCell. # GO_function GO:0003723 RNA binding; IEA:InterPro. # GO_function GO:0004519 endonuclease activity; IEA:UniProtKB-KW. # GO_function GO:0008996 ribonuclease G activity; IDA:EcoliWiki. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006364 rRNA processing; IMP:EcoliWiki. # GO_process GO:0007049 cell cycle; IEA:UniProtKB-KW. # GO_process GO:0051301 cell division; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005856 cytoskeleton # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0004518 nuclease activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0007049 cell cycle # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0051301 cell division # IntAct P0A9J0 20 # InterPro IPR003029 S1_domain # InterPro IPR004659 RNase_E/G # InterPro IPR012340 NA-bd_OB-fold # InterPro IPR019307 RNA-bd_AU-1/RNase_E/G # InterPro IPR022967 S1_dom # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # Organism RNG_ECOLI Escherichia coli (strain K12) # PATRIC 32121920 VBIEscCol129921_3344 # PIR A65117 A65117 # PROSITE PS50126 S1 # Pfam PF00575 S1 # Pfam PF10150 RNase_E_G # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RNG_ECOLI Ribonuclease G # RefSeq NP_417713 NC_000913.3 # RefSeq WP_000123197 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA58050.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the RNase E/G family. RNase G subfamily. {ECO 0000305}. # SIMILARITY Contains 1 S1 motif domain. {ECO:0000255|PROSITE- ProRule PRU00180}. # SMART SM00316 S1 # SUBCELLULAR LOCATION RNG_ECOLI Cytoplasm, cytoskeleton. # SUPFAM SSF50249 SSF50249 # TIGRFAMs TIGR00757 RNaseEG # eggNOG COG1530 LUCA # eggNOG ENOG4105C03 Bacteria BLAST swissprot:RNG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RNG_ECOLI BioCyc ECOL316407:JW3216-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3216-MONOMER BioCyc EcoCyc:EG11299-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11299-MONOMER BioCyc MetaCyc:EG11299-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11299-MONOMER COG COG1530 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1530 DIP DIP-48098N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48098N DOI 10.1006/bbrc.1999.0806 http://dx.doi.org/10.1006/bbrc.1999.0806 DOI 10.1016/0378-1119(91)90578-Y http://dx.doi.org/10.1016/0378-1119(91)90578-Y DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.26.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.26.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X57166 http://www.ebi.ac.uk/ena/data/view/X57166 ENZYME 3.1.26.- http://enzyme.expasy.org/EC/3.1.26.- EchoBASE EB1276 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1276 EcoGene EG11299 http://www.ecogene.org/geneInfo.php?eg_id=EG11299 EnsemblBacteria AAC76279 http://www.ensemblgenomes.org/id/AAC76279 EnsemblBacteria AAC76279 http://www.ensemblgenomes.org/id/AAC76279 EnsemblBacteria BAE77289 http://www.ensemblgenomes.org/id/BAE77289 EnsemblBacteria BAE77289 http://www.ensemblgenomes.org/id/BAE77289 EnsemblBacteria BAE77289 http://www.ensemblgenomes.org/id/BAE77289 EnsemblBacteria b3247 http://www.ensemblgenomes.org/id/b3247 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005856 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005856 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0004519 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004519 GO_function GO:0008996 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008996 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006364 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006364 GO_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005856 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005856 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GeneID 947744 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947744 HOGENOM HOG000258025 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000258025&db=HOGENOM6 InParanoid P0A9J0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9J0 IntAct P0A9J0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9J0* IntEnz 3.1.26 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.26 InterPro IPR003029 http://www.ebi.ac.uk/interpro/entry/IPR003029 InterPro IPR004659 http://www.ebi.ac.uk/interpro/entry/IPR004659 InterPro IPR012340 http://www.ebi.ac.uk/interpro/entry/IPR012340 InterPro IPR019307 http://www.ebi.ac.uk/interpro/entry/IPR019307 InterPro IPR022967 http://www.ebi.ac.uk/interpro/entry/IPR022967 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW3216 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3216 KEGG_Gene eco:b3247 http://www.genome.jp/dbget-bin/www_bget?eco:b3247 KEGG_Orthology KO:K08301 http://www.genome.jp/dbget-bin/www_bget?KO:K08301 MINT MINT-1221298 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1221298 OMA HQRQVLR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HQRQVLR PROSITE PS50126 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50126 PSORT swissprot:RNG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RNG_ECOLI PSORT-B swissprot:RNG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RNG_ECOLI PSORT2 swissprot:RNG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RNG_ECOLI Pfam PF00575 http://pfam.xfam.org/family/PF00575 Pfam PF10150 http://pfam.xfam.org/family/PF10150 Phobius swissprot:RNG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RNG_ECOLI PhylomeDB P0A9J0 http://phylomedb.org/?seqid=P0A9J0 ProteinModelPortal P0A9J0 http://www.proteinmodelportal.org/query/uniprot/P0A9J0 PubMed 10362534 http://www.ncbi.nlm.nih.gov/pubmed/10362534 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1937035 http://www.ncbi.nlm.nih.gov/pubmed/1937035 PubMed 8300545 http://www.ncbi.nlm.nih.gov/pubmed/8300545 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417713 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417713 RefSeq WP_000123197 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000123197 SMART SM00316 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00316 SMR P0A9J0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9J0 STRING 511145.b3247 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3247&targetmode=cogs STRING COG1530 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1530&targetmode=cogs SUPFAM SSF50249 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50249 TIGRFAMs TIGR00757 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00757 UniProtKB RNG_ECOLI http://www.uniprot.org/uniprot/RNG_ECOLI UniProtKB-AC P0A9J0 http://www.uniprot.org/uniprot/P0A9J0 charge swissprot:RNG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RNG_ECOLI eggNOG COG1530 http://eggnogapi.embl.de/nog_data/html/tree/COG1530 eggNOG ENOG4105C03 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C03 epestfind swissprot:RNG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RNG_ECOLI garnier swissprot:RNG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RNG_ECOLI helixturnhelix swissprot:RNG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RNG_ECOLI hmoment swissprot:RNG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RNG_ECOLI iep swissprot:RNG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RNG_ECOLI inforesidue swissprot:RNG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RNG_ECOLI octanol swissprot:RNG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RNG_ECOLI pepcoil swissprot:RNG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RNG_ECOLI pepdigest swissprot:RNG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RNG_ECOLI pepinfo swissprot:RNG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RNG_ECOLI pepnet swissprot:RNG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RNG_ECOLI pepstats swissprot:RNG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RNG_ECOLI pepwheel swissprot:RNG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RNG_ECOLI pepwindow swissprot:RNG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RNG_ECOLI sigcleave swissprot:RNG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RNG_ECOLI ## Database ID URL or Descriptions # AltName AQPZ_ECOLI Bacterial nodulin-like intrinsic protein # BioGrid 4260000 107 # CDD cd00333 MIP # DOMAIN AQPZ_ECOLI Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). # EcoGene EG13270 aqpZ # FUNCTION AQPZ_ECOLI Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity. {ECO 0000269|PubMed 10400575, ECO 0000269|PubMed 10518952, ECO 0000269|PubMed 11493683}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IDA:EcoliWiki. # GO_function GO:0015250 water channel activity; IDA:EcoCyc. # GO_function GO:0015254 glycerol channel activity; IBA:GO_Central. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0006833 water transport; IMP:CACAO. # GO_process GO:0006970 response to osmotic stress; IMP:EcoCyc. # GO_process GO:0009992 cellular water homeostasis; IMP:EcoCyc. # GO_process GO:0034220 ion transmembrane transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0006950 response to stress # GOslim_process GO:0042592 homeostatic process # GOslim_process GO:0055085 transmembrane transport # Gene3D 1.20.1080.10 -; 1. # HAMAP MF_01146 Aquaporin_Z # INDUCTION AQPZ_ECOLI By extracellular hypoosmotic conditions, especially during the mid-logarithmic phase of growth. # InterPro IPR000425 MIP # InterPro IPR022357 MIP_CS # InterPro IPR023271 Aquaporin-like # InterPro IPR023743 Aquaporin_Z # KEGG_Brite ko04040 Ion channels # MISCELLANEOUS It is a remarkably rigid tetramer that does not dissociate even when solubilized in SDS. {ECO:0000305|PubMed 10518952}. # Organism AQPZ_ECOLI Escherichia coli (strain K12) # PANTHER PTHR19139 PTHR19139 # PATRIC 32116957 VBIEscCol129921_0904 # PDB 1RC2 X-ray; 2.50 A; A/B=1-231 # PDB 2ABM X-ray; 3.20 A; A/B/C/D/E/F/G/H=1-231 # PDB 2O9D X-ray; 2.30 A; A/B=1-231 # PDB 2O9E X-ray; 2.20 A; A=1-231 # PDB 2O9F X-ray; 2.55 A; A/B=1-231 # PDB 2O9G X-ray; 1.90 A; A=1-231 # PDB 3NK5 X-ray; 2.40 A; A/B=1-231 # PDB 3NKA X-ray; 2.50 A; A/B=1-231 # PDB 3NKC X-ray; 3.10 A; A/B=1-231 # PIR C64826 C64826 # PRINTS PR00783 MINTRINSICP # PROSITE PS00221 MIP # Pfam PF00230 MIP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AQPZ_ECOLI Aquaporin Z # RefSeq NP_415396 NC_000913.3 # RefSeq WP_001298299 NZ_LN832404.1 # SIMILARITY Belongs to the MIP/aquaporin (TC 1.A.8) family. {ECO 0000305}. # SUBCELLULAR LOCATION AQPZ_ECOLI Cell inner membrane {ECO 0000269|PubMed 10487750, ECO 0000269|PubMed 10518952}; Multi- pass membrane protein {ECO 0000269|PubMed 10487750, ECO 0000269|PubMed 10518952}. # SUBUNIT AQPZ_ECOLI Homotetramer. {ECO 0000269|PubMed 10487750, ECO 0000269|PubMed 10518952, ECO 0000269|PubMed 10518953}. # SUPFAM SSF81338 SSF81338 # TCDB 1.A.8.3 the major intrinsic protein (mip) family # TIGRFAMs TIGR00861 MIP # eggNOG COG0580 LUCA # eggNOG ENOG4105D8C Bacteria BLAST swissprot:AQPZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AQPZ_ECOLI BioCyc ECOL316407:JW0859-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0859-MONOMER BioCyc EcoCyc:AQPZ-MONOMER http://biocyc.org/getid?id=EcoCyc:AQPZ-MONOMER BioCyc MetaCyc:AQPZ-MONOMER http://biocyc.org/getid?id=MetaCyc:AQPZ-MONOMER COG COG0580 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0580 DIP DIP-35499N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35499N DOI 10.1006/jmbi.1999.3031 http://dx.doi.org/10.1006/jmbi.1999.3031 DOI 10.1006/jmbi.1999.3032 http://dx.doi.org/10.1006/jmbi.1999.3032 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2000.02016.x http://dx.doi.org/10.1046/j.1365-2958.2000.02016.x DOI 10.1073/pnas.161299398 http://dx.doi.org/10.1073/pnas.161299398 DOI 10.1074/jbc.270.49.29063 http://dx.doi.org/10.1074/jbc.270.49.29063 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/emboj/18.18.4981 http://dx.doi.org/10.1093/emboj/18.18.4981 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pbio.0000072 http://dx.doi.org/10.1371/journal.pbio.0000072 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D49469 http://www.ebi.ac.uk/ena/data/view/D49469 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U38664 http://www.ebi.ac.uk/ena/data/view/U38664 EchoBASE EB1283 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1283 EcoGene EG13270 http://www.ecogene.org/geneInfo.php?eg_id=EG13270 EnsemblBacteria AAC73962 http://www.ensemblgenomes.org/id/AAC73962 EnsemblBacteria AAC73962 http://www.ensemblgenomes.org/id/AAC73962 EnsemblBacteria BAA35589 http://www.ensemblgenomes.org/id/BAA35589 EnsemblBacteria BAA35589 http://www.ensemblgenomes.org/id/BAA35589 EnsemblBacteria BAA35589 http://www.ensemblgenomes.org/id/BAA35589 EnsemblBacteria b0875 http://www.ensemblgenomes.org/id/b0875 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015250 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015250 GO_function GO:0015254 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015254 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0006833 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006833 GO_process GO:0006970 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006970 GO_process GO:0009992 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009992 GO_process GO:0034220 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 1.20.1080.10 http://www.cathdb.info/version/latest/superfamily/1.20.1080.10 GeneID 945497 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945497 HAMAP MF_01146 http://hamap.expasy.org/unirule/MF_01146 HOGENOM HOG000288286 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000288286&db=HOGENOM6 InParanoid P60844 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P60844 InterPro IPR000425 http://www.ebi.ac.uk/interpro/entry/IPR000425 InterPro IPR022357 http://www.ebi.ac.uk/interpro/entry/IPR022357 InterPro IPR023271 http://www.ebi.ac.uk/interpro/entry/IPR023271 InterPro IPR023743 http://www.ebi.ac.uk/interpro/entry/IPR023743 KEGG_Brite ko04040 http://www.genome.jp/dbget-bin/www_bget?ko04040 KEGG_Gene ecj:JW0859 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0859 KEGG_Gene eco:b0875 http://www.genome.jp/dbget-bin/www_bget?eco:b0875 KEGG_Orthology KO:K06188 http://www.genome.jp/dbget-bin/www_bget?KO:K06188 OMA MPIIGGI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MPIIGGI PANTHER PTHR19139 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19139 PDB 1RC2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1RC2 PDB 2ABM http://www.ebi.ac.uk/pdbe-srv/view/entry/2ABM PDB 2O9D http://www.ebi.ac.uk/pdbe-srv/view/entry/2O9D PDB 2O9E http://www.ebi.ac.uk/pdbe-srv/view/entry/2O9E PDB 2O9F http://www.ebi.ac.uk/pdbe-srv/view/entry/2O9F PDB 2O9G http://www.ebi.ac.uk/pdbe-srv/view/entry/2O9G PDB 3NK5 http://www.ebi.ac.uk/pdbe-srv/view/entry/3NK5 PDB 3NKA http://www.ebi.ac.uk/pdbe-srv/view/entry/3NKA PDB 3NKC http://www.ebi.ac.uk/pdbe-srv/view/entry/3NKC PDBsum 1RC2 http://www.ebi.ac.uk/pdbsum/1RC2 PDBsum 2ABM http://www.ebi.ac.uk/pdbsum/2ABM PDBsum 2O9D http://www.ebi.ac.uk/pdbsum/2O9D PDBsum 2O9E http://www.ebi.ac.uk/pdbsum/2O9E PDBsum 2O9F http://www.ebi.ac.uk/pdbsum/2O9F PDBsum 2O9G http://www.ebi.ac.uk/pdbsum/2O9G PDBsum 3NK5 http://www.ebi.ac.uk/pdbsum/3NK5 PDBsum 3NKA http://www.ebi.ac.uk/pdbsum/3NKA PDBsum 3NKC http://www.ebi.ac.uk/pdbsum/3NKC PRINTS PR00783 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00783 PROSITE PS00221 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00221 PSORT swissprot:AQPZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AQPZ_ECOLI PSORT-B swissprot:AQPZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AQPZ_ECOLI PSORT2 swissprot:AQPZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AQPZ_ECOLI Pfam PF00230 http://pfam.xfam.org/family/PF00230 Phobius swissprot:AQPZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AQPZ_ECOLI PhylomeDB P60844 http://phylomedb.org/?seqid=P60844 ProteinModelPortal P60844 http://www.proteinmodelportal.org/query/uniprot/P60844 PubMed 10400575 http://www.ncbi.nlm.nih.gov/pubmed/10400575 PubMed 10487750 http://www.ncbi.nlm.nih.gov/pubmed/10487750 PubMed 10518952 http://www.ncbi.nlm.nih.gov/pubmed/10518952 PubMed 10518953 http://www.ncbi.nlm.nih.gov/pubmed/10518953 PubMed 10931322 http://www.ncbi.nlm.nih.gov/pubmed/10931322 PubMed 11493683 http://www.ncbi.nlm.nih.gov/pubmed/11493683 PubMed 14691544 http://www.ncbi.nlm.nih.gov/pubmed/14691544 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7493926 http://www.ncbi.nlm.nih.gov/pubmed/7493926 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9137831 http://www.ncbi.nlm.nih.gov/pubmed/9137831 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415396 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415396 RefSeq WP_001298299 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001298299 SMR P60844 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P60844 STRING 511145.b0875 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0875&targetmode=cogs STRING COG0580 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0580&targetmode=cogs SUPFAM SSF81338 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81338 TCDB 1.A.8.3 http://www.tcdb.org/search/result.php?tc=1.A.8.3 TIGRFAMs TIGR00861 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00861 UniProtKB AQPZ_ECOLI http://www.uniprot.org/uniprot/AQPZ_ECOLI UniProtKB-AC P60844 http://www.uniprot.org/uniprot/P60844 charge swissprot:AQPZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AQPZ_ECOLI eggNOG COG0580 http://eggnogapi.embl.de/nog_data/html/tree/COG0580 eggNOG ENOG4105D8C http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D8C epestfind swissprot:AQPZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AQPZ_ECOLI garnier swissprot:AQPZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AQPZ_ECOLI helixturnhelix swissprot:AQPZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AQPZ_ECOLI hmoment swissprot:AQPZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AQPZ_ECOLI iep swissprot:AQPZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AQPZ_ECOLI inforesidue swissprot:AQPZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AQPZ_ECOLI octanol swissprot:AQPZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AQPZ_ECOLI pepcoil swissprot:AQPZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AQPZ_ECOLI pepdigest swissprot:AQPZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AQPZ_ECOLI pepinfo swissprot:AQPZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AQPZ_ECOLI pepnet swissprot:AQPZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AQPZ_ECOLI pepstats swissprot:AQPZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AQPZ_ECOLI pepwheel swissprot:AQPZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AQPZ_ECOLI pepwindow swissprot:AQPZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AQPZ_ECOLI sigcleave swissprot:AQPZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AQPZ_ECOLI ## Database ID URL or Descriptions # AltName YCGR_ECOLI Cyclic di-GMP binding protein YcgR # BioGrid 4260858 131 # DISRUPTION PHENOTYPE YCGR_ECOLI No visible motility phenotype. Disruption of this gene suppresses the reduced motility of a yhjH disruption, thus the double disruption is motile. {ECO 0000269|PubMed 16920715, ECO 0000269|PubMed 20303158}. # DOMAIN YCGR_ECOLI The N-terminal domain is involved in FliG binding, the C- terminal domain is involved in FliM binding. {ECO 0000269|PubMed 16249258}. # DOMAIN YCGR_ECOLI The PilZ domain is able to bind c-di-GMP, but with a lower affinity (dissociation constant of 1.45 uM) compared to the whole protein (dissociation constant of 0.84 uM). {ECO 0000269|PubMed 16249258}. # EcoGene EG13899 ycgR # FUNCTION YCGR_ECOLI Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. When bound to c-di-GMP it binds to elements of the flagellar motor (MotA (PubMed 20303158) and/or FliG and FliM (PubMed 20346719), binding to FliM also occurs in the absence of c-di-GMP), causing the motor to slow down. Thus, increasing levels of c-di-GMP lead to decreased motility. Probably binds 1 c-di-GMP dimer per subunit. {ECO 0000269|PubMed 11031114, ECO 0000269|PubMed 16920715, ECO 0000269|PubMed 20303158, ECO 0000269|PubMed 20346719}. # GO_component GO:0009425 bacterial-type flagellum basal body; IEA:UniProtKB-SubCell. # GO_function GO:0010181 FMN binding; IEA:InterPro. # GO_function GO:0016491 oxidoreductase activity; IEA:InterPro. # GO_function GO:0035438 cyclic-di-GMP binding; IDA:UniProtKB. # GO_process GO:0071945 regulation of bacterial-type flagellum-dependent cell motility by regulation of motor speed; IGI:UniProtKB. # GO_process GO:0071973 bacterial-type flagellum-dependent cell motility; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0048870 cell motility # Gene3D 2.30.110.10 -; 1. # HAMAP MF_01457 YcgR # INTERACTION YCGR_ECOLI P0ABZ1 fliG; NbExp=3; IntAct=EBI-554507, EBI-1126524; P06974 fliM; NbExp=3; IntAct=EBI-554507, EBI-560439; # IntAct P76010 7 # InterPro IPR009875 PilZ_domain # InterPro IPR009926 T3SS_YcgR_N # InterPro IPR012349 Split_barrel_FMN-bd # InterPro IPR023787 T3SS_YcgR # Organism YCGR_ECOLI Escherichia coli (strain K12) # PATRIC 32117636 VBIEscCol129921_1240 # PIR G64865 G64865 # Pfam PF07238 PilZ # Pfam PF07317 YcgR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCGR_ECOLI Flagellar brake protein YcgR # RefSeq NP_415712 NC_000913.3 # RefSeq WP_000020169 NZ_LN832404.1 # SIMILARITY Belongs to the YcgR family. {ECO 0000305}. # SIMILARITY Contains 1 PilZ domain. {ECO 0000305}. # SUBCELLULAR LOCATION YCGR_ECOLI Bacterial flagellum basal body {ECO 0000269|PubMed 20303158}. # SUBUNIT YCGR_ECOLI Monomer (Probable). Interacts with MotA in the flagellar basal bodies (PubMed 20303158). In another study (PubMed 20346719) it was not seen to interact with MotA, but instead with FliM and FliG, also in the flagellar basal body. {ECO 0000269|PubMed 16920715, ECO 0000269|PubMed 20303158, ECO 0000269|PubMed 20346719, ECO 0000305}. # eggNOG COG5581 LUCA # eggNOG ENOG4108T7K Bacteria BLAST swissprot:YCGR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCGR_ECOLI BioCyc ECOL316407:JW1183-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1183-MONOMER BioCyc EcoCyc:G6623-MONOMER http://biocyc.org/getid?id=EcoCyc:G6623-MONOMER DIP DIP-11561N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11561N DOI 10.1006/jmbi.2000.4147 http://dx.doi.org/10.1006/jmbi.2000.4147 DOI 10.1016/j.cell.2010.01.018 http://dx.doi.org/10.1016/j.cell.2010.01.018 DOI 10.1016/j.molcel.2010.03.001 http://dx.doi.org/10.1016/j.molcel.2010.03.001 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.C600179200 http://dx.doi.org/10.1074/jbc.C600179200 DOI 10.1093/bioinformatics/bti739 http://dx.doi.org/10.1093/bioinformatics/bti739 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3658 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3658 EcoGene EG13899 http://www.ecogene.org/geneInfo.php?eg_id=EG13899 EnsemblBacteria AAC74278 http://www.ensemblgenomes.org/id/AAC74278 EnsemblBacteria AAC74278 http://www.ensemblgenomes.org/id/AAC74278 EnsemblBacteria BAA36052 http://www.ensemblgenomes.org/id/BAA36052 EnsemblBacteria BAA36052 http://www.ensemblgenomes.org/id/BAA36052 EnsemblBacteria BAA36052 http://www.ensemblgenomes.org/id/BAA36052 EnsemblBacteria b1194 http://www.ensemblgenomes.org/id/b1194 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009425 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009425 GO_function GO:0010181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010181 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0035438 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035438 GO_process GO:0071945 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071945 GO_process GO:0071973 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071973 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 Gene3D 2.30.110.10 http://www.cathdb.info/version/latest/superfamily/2.30.110.10 GeneID 947609 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947609 HAMAP MF_01457 http://hamap.expasy.org/unirule/MF_01457 HOGENOM HOG000265609 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000265609&db=HOGENOM6 IntAct P76010 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76010* InterPro IPR009875 http://www.ebi.ac.uk/interpro/entry/IPR009875 InterPro IPR009926 http://www.ebi.ac.uk/interpro/entry/IPR009926 InterPro IPR012349 http://www.ebi.ac.uk/interpro/entry/IPR012349 InterPro IPR023787 http://www.ebi.ac.uk/interpro/entry/IPR023787 KEGG_Gene ecj:JW1183 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1183 KEGG_Gene eco:b1194 http://www.genome.jp/dbget-bin/www_bget?eco:b1194 OMA VMIVHAR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VMIVHAR PSORT swissprot:YCGR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCGR_ECOLI PSORT-B swissprot:YCGR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCGR_ECOLI PSORT2 swissprot:YCGR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCGR_ECOLI Pfam PF07238 http://pfam.xfam.org/family/PF07238 Pfam PF07317 http://pfam.xfam.org/family/PF07317 Phobius swissprot:YCGR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCGR_ECOLI ProteinModelPortal P76010 http://www.proteinmodelportal.org/query/uniprot/P76010 PubMed 11031114 http://www.ncbi.nlm.nih.gov/pubmed/11031114 PubMed 16249258 http://www.ncbi.nlm.nih.gov/pubmed/16249258 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16920715 http://www.ncbi.nlm.nih.gov/pubmed/16920715 PubMed 20303158 http://www.ncbi.nlm.nih.gov/pubmed/20303158 PubMed 20346719 http://www.ncbi.nlm.nih.gov/pubmed/20346719 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415712 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415712 RefSeq WP_000020169 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000020169 SMR P76010 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76010 STRING 511145.b1194 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1194&targetmode=cogs UniProtKB YCGR_ECOLI http://www.uniprot.org/uniprot/YCGR_ECOLI UniProtKB-AC P76010 http://www.uniprot.org/uniprot/P76010 charge swissprot:YCGR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCGR_ECOLI eggNOG COG5581 http://eggnogapi.embl.de/nog_data/html/tree/COG5581 eggNOG ENOG4108T7K http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108T7K epestfind swissprot:YCGR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCGR_ECOLI garnier swissprot:YCGR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCGR_ECOLI helixturnhelix swissprot:YCGR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCGR_ECOLI hmoment swissprot:YCGR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCGR_ECOLI iep swissprot:YCGR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCGR_ECOLI inforesidue swissprot:YCGR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCGR_ECOLI octanol swissprot:YCGR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCGR_ECOLI pepcoil swissprot:YCGR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCGR_ECOLI pepdigest swissprot:YCGR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCGR_ECOLI pepinfo swissprot:YCGR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCGR_ECOLI pepnet swissprot:YCGR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCGR_ECOLI pepstats swissprot:YCGR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCGR_ECOLI pepwheel swissprot:YCGR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCGR_ECOLI pepwindow swissprot:YCGR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCGR_ECOLI sigcleave swissprot:YCGR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCGR_ECOLI ## Database ID URL or Descriptions # BioGrid 4262098 10 # EcoGene EG13689 ybjT # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GOslim_component GO:0005886 plasma membrane # Gene3D 3.40.50.720 -; 1. # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR021295 DUF2867 # Organism YBJT_ECOLI Escherichia coli (strain K12) # PATRIC 32116945 VBIEscCol129921_0898 # PIR E64825 E64825 # Pfam PF11066 DUF2867 # Pfam PF13460 NAD_binding_10 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBJT_ECOLI Uncharacterized protein YbjT # RefSeq NP_415390 NC_000913.3 # RefSeq WP_001136554 NZ_LN832404.1 # SUPFAM SSF51735 SSF51735 # eggNOG COG0702 LUCA # eggNOG ENOG4105CGD Bacteria BLAST swissprot:YBJT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBJT_ECOLI BioCyc ECOL316407:JW5116-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5116-MONOMER BioCyc EcoCyc:G6454-MONOMER http://biocyc.org/getid?id=EcoCyc:G6454-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3453 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3453 EcoGene EG13689 http://www.ecogene.org/geneInfo.php?eg_id=EG13689 EnsemblBacteria AAC73956 http://www.ensemblgenomes.org/id/AAC73956 EnsemblBacteria AAC73956 http://www.ensemblgenomes.org/id/AAC73956 EnsemblBacteria BAA35583 http://www.ensemblgenomes.org/id/BAA35583 EnsemblBacteria BAA35583 http://www.ensemblgenomes.org/id/BAA35583 EnsemblBacteria BAA35583 http://www.ensemblgenomes.org/id/BAA35583 EnsemblBacteria b0869 http://www.ensemblgenomes.org/id/b0869 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 945496 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945496 HOGENOM HOG000241598 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000241598&db=HOGENOM6 InParanoid P75822 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75822 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR021295 http://www.ebi.ac.uk/interpro/entry/IPR021295 KEGG_Gene ecj:JW5116 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5116 KEGG_Gene eco:b0869 http://www.genome.jp/dbget-bin/www_bget?eco:b0869 OMA YWLYFVT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YWLYFVT PSORT swissprot:YBJT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBJT_ECOLI PSORT-B swissprot:YBJT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBJT_ECOLI PSORT2 swissprot:YBJT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBJT_ECOLI Pfam PF11066 http://pfam.xfam.org/family/PF11066 Pfam PF13460 http://pfam.xfam.org/family/PF13460 Phobius swissprot:YBJT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBJT_ECOLI PhylomeDB P75822 http://phylomedb.org/?seqid=P75822 ProteinModelPortal P75822 http://www.proteinmodelportal.org/query/uniprot/P75822 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415390 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415390 RefSeq WP_001136554 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001136554 STRING 511145.b0869 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0869&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB YBJT_ECOLI http://www.uniprot.org/uniprot/YBJT_ECOLI UniProtKB-AC P75822 http://www.uniprot.org/uniprot/P75822 charge swissprot:YBJT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBJT_ECOLI eggNOG COG0702 http://eggnogapi.embl.de/nog_data/html/tree/COG0702 eggNOG ENOG4105CGD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CGD epestfind swissprot:YBJT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBJT_ECOLI garnier swissprot:YBJT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBJT_ECOLI helixturnhelix swissprot:YBJT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBJT_ECOLI hmoment swissprot:YBJT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBJT_ECOLI iep swissprot:YBJT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBJT_ECOLI inforesidue swissprot:YBJT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBJT_ECOLI octanol swissprot:YBJT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBJT_ECOLI pepcoil swissprot:YBJT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBJT_ECOLI pepdigest swissprot:YBJT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBJT_ECOLI pepinfo swissprot:YBJT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBJT_ECOLI pepnet swissprot:YBJT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBJT_ECOLI pepstats swissprot:YBJT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBJT_ECOLI pepwheel swissprot:YBJT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBJT_ECOLI pepwindow swissprot:YBJT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBJT_ECOLI sigcleave swissprot:YBJT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBJT_ECOLI ## Database ID URL or Descriptions # AltName GADC_ECOLI Extreme acid sensitivity protein # BioGrid 4260789 7 # EcoGene EG12456 gadC # FUNCTION GADC_ECOLI Involved in glutamate-dependent acid resistance. Imports glutamate inside the cell while simultaneously exporting to the periplasm the GABA produced by GadA and GadB. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0015179 L-amino acid transmembrane transporter activity; IBA:GO_Central. # GO_function GO:0015297 antiporter activity; ISS:EcoCyc. # GO_process GO:0051454 intracellular pH elevation; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0042592 homeostatic process # INDUCTION GADC_ECOLI By acidic conditions. Expression is regulated by a complex system involving RpoS, cAMP, CRP, EvgAS, H-NS, GadE, GadW and GadX. The level of involvement for each regulator varies depending upon the growth phase and the medium. {ECO 0000269|PubMed 10383761, ECO 0000269|PubMed 11976288, ECO 0000269|PubMed 12399493, ECO 0000269|PubMed 12694615, ECO 0000269|PubMed 12867478, ECO 0000269|PubMed 12940989}. # InterPro IPR002293 AA/rel_permease1 # InterPro IPR004759 Glu_antiport # MISCELLANEOUS GADC_ECOLI The glutamate analog L-trans-pyrrolidine-2,4- dicarboxylic acid (L-PDC) blocks the uptake of glutamate by selective inhibition. # Organism GADC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11785 PTHR11785 # PATRIC 32118278 VBIEscCol129921_1559 # PDB 4DJI X-ray; 3.19 A; A/B=1-511 # PDB 4DJK X-ray; 3.10 A; A/B=1-511 # PIR G64902 G64902 # PIRSF PIRSF006060 AA_transporter # Pfam PF13520 AA_permease_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GADC_ECOLI Probable glutamate/gamma-aminobutyrate antiporter # RefSeq NP_416009 NC_000913.3 # RefSeq WP_000246019 NZ_LN832404.1 # SIMILARITY Belongs to the amino acid-polyamine-organocation (APC) superfamily. Glutamate:GABA antiporter (GGA) (TC 2.A.3.7) family. {ECO 0000305}. # SUBCELLULAR LOCATION GADC_ECOLI Cell inner membrane; Multi-pass membrane protein. # TIGRFAMs TIGR00910 2A0307_GadC # eggNOG COG0531 LUCA # eggNOG ENOG4105E5D Bacteria BLAST swissprot:GADC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GADC_ECOLI BioCyc ECOL316407:JW1487-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1487-MONOMER BioCyc EcoCyc:XASA-MONOMER http://biocyc.org/getid?id=EcoCyc:XASA-MONOMER BioCyc MetaCyc:XASA-MONOMER http://biocyc.org/getid?id=MetaCyc:XASA-MONOMER DIP DIP-48121N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48121N DOI 10.1016/S0378-1097(03)00427-0 http://dx.doi.org/10.1016/S0378-1097(03)00427-0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1999.01430.x http://dx.doi.org/10.1046/j.1365-2958.1999.01430.x DOI 10.1046/j.1365-2958.2003.03477.x http://dx.doi.org/10.1046/j.1365-2958.2003.03477.x DOI 10.1046/j.1365-2958.2003.03633.x http://dx.doi.org/10.1046/j.1365-2958.2003.03633.x DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.10.2603-2613.2002 http://dx.doi.org/10.1128/JB.184.10.2603-2613.2002 DOI 10.1128/JB.184.22.6225-6234.2002 http://dx.doi.org/10.1128/JB.184.22.6225-6234.2002 DOI 10.1128/JB.185.15.4644-4647.2003 http://dx.doi.org/10.1128/JB.185.15.4644-4647.2003 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U13204 http://www.ebi.ac.uk/ena/data/view/U13204 EchoBASE EB2350 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2350 EcoGene EG12456 http://www.ecogene.org/geneInfo.php?eg_id=EG12456 EnsemblBacteria AAC74565 http://www.ensemblgenomes.org/id/AAC74565 EnsemblBacteria AAC74565 http://www.ensemblgenomes.org/id/AAC74565 EnsemblBacteria BAA15156 http://www.ensemblgenomes.org/id/BAA15156 EnsemblBacteria BAA15156 http://www.ensemblgenomes.org/id/BAA15156 EnsemblBacteria BAA15156 http://www.ensemblgenomes.org/id/BAA15156 EnsemblBacteria b1492 http://www.ensemblgenomes.org/id/b1492 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015179 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015179 GO_function GO:0015297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015297 GO_process GO:0051454 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051454 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GeneID 946057 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946057 HOGENOM HOG000058004 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000058004&db=HOGENOM6 InParanoid P63235 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P63235 InterPro IPR002293 http://www.ebi.ac.uk/interpro/entry/IPR002293 InterPro IPR004759 http://www.ebi.ac.uk/interpro/entry/IPR004759 KEGG_Gene ecj:JW1487 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1487 KEGG_Gene eco:b1492 http://www.genome.jp/dbget-bin/www_bget?eco:b1492 OMA VYKINPE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VYKINPE PANTHER PTHR11785 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11785 PDB 4DJI http://www.ebi.ac.uk/pdbe-srv/view/entry/4DJI PDB 4DJK http://www.ebi.ac.uk/pdbe-srv/view/entry/4DJK PDBsum 4DJI http://www.ebi.ac.uk/pdbsum/4DJI PDBsum 4DJK http://www.ebi.ac.uk/pdbsum/4DJK PSORT swissprot:GADC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GADC_ECOLI PSORT-B swissprot:GADC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GADC_ECOLI PSORT2 swissprot:GADC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GADC_ECOLI Pfam PF13520 http://pfam.xfam.org/family/PF13520 Phobius swissprot:GADC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GADC_ECOLI PhylomeDB P63235 http://phylomedb.org/?seqid=P63235 ProteinModelPortal P63235 http://www.proteinmodelportal.org/query/uniprot/P63235 PubMed 10383761 http://www.ncbi.nlm.nih.gov/pubmed/10383761 PubMed 11976288 http://www.ncbi.nlm.nih.gov/pubmed/11976288 PubMed 12399493 http://www.ncbi.nlm.nih.gov/pubmed/12399493 PubMed 12694615 http://www.ncbi.nlm.nih.gov/pubmed/12694615 PubMed 12855178 http://www.ncbi.nlm.nih.gov/pubmed/12855178 PubMed 12867478 http://www.ncbi.nlm.nih.gov/pubmed/12867478 PubMed 12940989 http://www.ncbi.nlm.nih.gov/pubmed/12940989 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8682809 http://www.ncbi.nlm.nih.gov/pubmed/8682809 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416009 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416009 RefSeq WP_000246019 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000246019 SMR P63235 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P63235 STRING 511145.b1492 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1492&targetmode=cogs TIGRFAMs TIGR00910 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00910 UniProtKB GADC_ECOLI http://www.uniprot.org/uniprot/GADC_ECOLI UniProtKB-AC P63235 http://www.uniprot.org/uniprot/P63235 charge swissprot:GADC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GADC_ECOLI eggNOG COG0531 http://eggnogapi.embl.de/nog_data/html/tree/COG0531 eggNOG ENOG4105E5D http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E5D epestfind swissprot:GADC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GADC_ECOLI garnier swissprot:GADC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GADC_ECOLI helixturnhelix swissprot:GADC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GADC_ECOLI hmoment swissprot:GADC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GADC_ECOLI iep swissprot:GADC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GADC_ECOLI inforesidue swissprot:GADC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GADC_ECOLI octanol swissprot:GADC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GADC_ECOLI pepcoil swissprot:GADC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GADC_ECOLI pepdigest swissprot:GADC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GADC_ECOLI pepinfo swissprot:GADC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GADC_ECOLI pepnet swissprot:GADC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GADC_ECOLI pepstats swissprot:GADC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GADC_ECOLI pepwheel swissprot:GADC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GADC_ECOLI pepwindow swissprot:GADC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GADC_ECOLI sigcleave swissprot:GADC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GADC_ECOLI ## Database ID URL or Descriptions # BioGrid 4260415 13 # EcoGene EG11894 yeeD # Gene3D 3.30.110.40 -; 1. # INTERACTION YEED_ECOLI P63284 clpB; NbExp=3; IntAct=EBI-9130839, EBI-546182; # IntAct P33014 20 # InterPro IPR001455 TusA-like # Organism YEED_ECOLI Escherichia coli (strain K12) # PATRIC 32119359 VBIEscCol129921_2089 # PIR C64966 C64966 # PROSITE PS01148 UPF0033 # Pfam PF01206 TusA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEED_ECOLI UPF0033 protein YeeD # RefSeq NP_416516 NC_000913.3 # RefSeq WP_000234896 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0033 family. {ECO 0000305}. # SUPFAM SSF64307 SSF64307 # eggNOG COG0425 LUCA BLAST swissprot:YEED_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEED_ECOLI BioCyc ECOL316407:JW1994-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1994-MONOMER BioCyc EcoCyc:EG11894-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11894-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00009 http://www.ebi.ac.uk/ena/data/view/U00009 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1840 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1840 EcoGene EG11894 http://www.ecogene.org/geneInfo.php?eg_id=EG11894 EnsemblBacteria AAC75073 http://www.ensemblgenomes.org/id/AAC75073 EnsemblBacteria AAC75073 http://www.ensemblgenomes.org/id/AAC75073 EnsemblBacteria BAA15840 http://www.ensemblgenomes.org/id/BAA15840 EnsemblBacteria BAA15840 http://www.ensemblgenomes.org/id/BAA15840 EnsemblBacteria BAA15840 http://www.ensemblgenomes.org/id/BAA15840 EnsemblBacteria b2012 http://www.ensemblgenomes.org/id/b2012 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.30.110.40 http://www.cathdb.info/version/latest/superfamily/3.30.110.40 GeneID 946539 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946539 HOGENOM HOG000259289 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000259289&db=HOGENOM6 IntAct P33014 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33014* InterPro IPR001455 http://www.ebi.ac.uk/interpro/entry/IPR001455 KEGG_Gene ecj:JW1994 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1994 KEGG_Gene eco:b2012 http://www.genome.jp/dbget-bin/www_bget?eco:b2012 OMA CTQATDS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CTQATDS PROSITE PS01148 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01148 PSORT swissprot:YEED_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEED_ECOLI PSORT-B swissprot:YEED_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEED_ECOLI PSORT2 swissprot:YEED_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEED_ECOLI Pfam PF01206 http://pfam.xfam.org/family/PF01206 Phobius swissprot:YEED_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEED_ECOLI PhylomeDB P33014 http://phylomedb.org/?seqid=P33014 ProteinModelPortal P33014 http://www.proteinmodelportal.org/query/uniprot/P33014 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416516 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416516 RefSeq WP_000234896 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000234896 SMR P33014 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33014 STRING 511145.b2012 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2012&targetmode=cogs SUPFAM SSF64307 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF64307 UniProtKB YEED_ECOLI http://www.uniprot.org/uniprot/YEED_ECOLI UniProtKB-AC P33014 http://www.uniprot.org/uniprot/P33014 charge swissprot:YEED_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEED_ECOLI eggNOG COG0425 http://eggnogapi.embl.de/nog_data/html/tree/COG0425 epestfind swissprot:YEED_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEED_ECOLI garnier swissprot:YEED_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEED_ECOLI helixturnhelix swissprot:YEED_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEED_ECOLI hmoment swissprot:YEED_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEED_ECOLI iep swissprot:YEED_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEED_ECOLI inforesidue swissprot:YEED_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEED_ECOLI octanol swissprot:YEED_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEED_ECOLI pepcoil swissprot:YEED_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEED_ECOLI pepdigest swissprot:YEED_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEED_ECOLI pepinfo swissprot:YEED_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEED_ECOLI pepnet swissprot:YEED_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEED_ECOLI pepstats swissprot:YEED_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEED_ECOLI pepwheel swissprot:YEED_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEED_ECOLI pepwindow swissprot:YEED_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEED_ECOLI sigcleave swissprot:YEED_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEED_ECOLI ## Database ID URL or Descriptions # AltName BGLX_ECOLI Beta-D-glucoside glucohydrolase # AltName BGLX_ECOLI Cellobiase # AltName BGLX_ECOLI Gentiobiase # BioGrid 4260451 5 # CATALYTIC ACTIVITY BGLX_ECOLI Hydrolysis of terminal, non-reducing beta-D- glucosyl residues with release of beta-D-glucose. # CAZy GH3 Glycoside Hydrolase Family 3 # EcoGene EG12013 bglX # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_component GO:0042597 periplasmic space; IDA:EcoliWiki. # GO_function GO:0008422 beta-glucosidase activity; IDA:EcoliWiki. # GO_function GO:0015926 glucosidase activity; IDA:EcoliWiki. # GO_function GO:0102483 scopolin beta-glucosidase activity; IEA:UniProtKB-EC. # GO_process GO:0009251 glucan catabolic process; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # Gene3D 3.20.20.300 -; 1. # Gene3D 3.40.50.1700 -; 1. # IntAct P33363 16 # InterPro IPR001764 Glyco_hydro_3_N # InterPro IPR002772 Glyco_hydro_3_C # InterPro IPR017853 Glycoside_hydrolase_SF # InterPro IPR019800 Glyco_hydro_3_AS # InterPro IPR026891 Fn3-like # InterPro IPR026892 Glyco_hydro_3 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00460 Cyanoamino acid metabolism # KEGG_Pathway ko00500 Starch and sucrose metabolism # KEGG_Pathway ko00940 Phenylpropanoid biosynthesis # Organism BGLX_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30620 PTHR30620; 2 # PATRIC 32119603 VBIEscCol129921_2212 # PIR C64981 C64981 # PRINTS PR00133 GLHYDRLASE3 # PROSITE PS00775 GLYCOSYL_HYDROL_F3 # Pfam PF00933 Glyco_hydro_3 # Pfam PF01915 Glyco_hydro_3_C # Pfam PF14310 Fn3-like # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BGLX_ECOLI Periplasmic beta-glucosidase # RefSeq NP_416636 NC_000913.3 # RefSeq WP_000871504 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA60495.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the glycosyl hydrolase 3 family. {ECO 0000305}. # SMART SM01217 Fn3_like # SUBCELLULAR LOCATION BGLX_ECOLI Periplasm. # SUPFAM SSF51445 SSF51445 # SUPFAM SSF52279 SSF52279; 2 # eggNOG COG1472 LUCA # eggNOG ENOG4107QK4 Bacteria BLAST swissprot:BGLX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BGLX_ECOLI BioCyc ECOL316407:JW2120-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2120-MONOMER BioCyc EcoCyc:EG12013-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12013-MONOMER BioCyc MetaCyc:EG12013-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12013-MONOMER COG COG1472 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1472 DIP DIP-9218N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9218N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.2.1.21 http://www.genome.jp/dbget-bin/www_bget?EC:3.2.1.21 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U15049 http://www.ebi.ac.uk/ena/data/view/U15049 ENZYME 3.2.1.21 http://enzyme.expasy.org/EC/3.2.1.21 EchoBASE EB1951 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1951 EcoGene EG12013 http://www.ecogene.org/geneInfo.php?eg_id=EG12013 EnsemblBacteria AAC75193 http://www.ensemblgenomes.org/id/AAC75193 EnsemblBacteria AAC75193 http://www.ensemblgenomes.org/id/AAC75193 EnsemblBacteria BAE76609 http://www.ensemblgenomes.org/id/BAE76609 EnsemblBacteria BAE76609 http://www.ensemblgenomes.org/id/BAE76609 EnsemblBacteria BAE76609 http://www.ensemblgenomes.org/id/BAE76609 EnsemblBacteria b2132 http://www.ensemblgenomes.org/id/b2132 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0008422 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008422 GO_function GO:0015926 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015926 GO_function GO:0102483 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0102483 GO_process GO:0009251 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009251 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 3.20.20.300 http://www.cathdb.info/version/latest/superfamily/3.20.20.300 Gene3D 3.40.50.1700 http://www.cathdb.info/version/latest/superfamily/3.40.50.1700 GeneID 946682 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946682 HOGENOM HOG000031217 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000031217&db=HOGENOM6 InParanoid P33363 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33363 IntAct P33363 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33363* IntEnz 3.2.1.21 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.2.1.21 InterPro IPR001764 http://www.ebi.ac.uk/interpro/entry/IPR001764 InterPro IPR002772 http://www.ebi.ac.uk/interpro/entry/IPR002772 InterPro IPR017853 http://www.ebi.ac.uk/interpro/entry/IPR017853 InterPro IPR019800 http://www.ebi.ac.uk/interpro/entry/IPR019800 InterPro IPR026891 http://www.ebi.ac.uk/interpro/entry/IPR026891 InterPro IPR026892 http://www.ebi.ac.uk/interpro/entry/IPR026892 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2120 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2120 KEGG_Gene eco:b2132 http://www.genome.jp/dbget-bin/www_bget?eco:b2132 KEGG_Orthology KO:K05349 http://www.genome.jp/dbget-bin/www_bget?KO:K05349 KEGG_Pathway ko00460 http://www.genome.jp/kegg-bin/show_pathway?ko00460 KEGG_Pathway ko00500 http://www.genome.jp/kegg-bin/show_pathway?ko00500 KEGG_Pathway ko00940 http://www.genome.jp/kegg-bin/show_pathway?ko00940 KEGG_Reaction rn:R00026 http://www.genome.jp/dbget-bin/www_bget?rn:R00026 KEGG_Reaction rn:R02558 http://www.genome.jp/dbget-bin/www_bget?rn:R02558 KEGG_Reaction rn:R02887 http://www.genome.jp/dbget-bin/www_bget?rn:R02887 KEGG_Reaction rn:R02985 http://www.genome.jp/dbget-bin/www_bget?rn:R02985 KEGG_Reaction rn:R03527 http://www.genome.jp/dbget-bin/www_bget?rn:R03527 KEGG_Reaction rn:R04949 http://www.genome.jp/dbget-bin/www_bget?rn:R04949 KEGG_Reaction rn:R04998 http://www.genome.jp/dbget-bin/www_bget?rn:R04998 KEGG_Reaction rn:R10035 http://www.genome.jp/dbget-bin/www_bget?rn:R10035 KEGG_Reaction rn:R10039 http://www.genome.jp/dbget-bin/www_bget?rn:R10039 KEGG_Reaction rn:R10040 http://www.genome.jp/dbget-bin/www_bget?rn:R10040 OMA IKHGVAS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IKHGVAS PANTHER PTHR30620 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30620 PRINTS PR00133 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00133 PROSITE PS00775 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00775 PSORT swissprot:BGLX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BGLX_ECOLI PSORT-B swissprot:BGLX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BGLX_ECOLI PSORT2 swissprot:BGLX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BGLX_ECOLI Pfam PF00933 http://pfam.xfam.org/family/PF00933 Pfam PF01915 http://pfam.xfam.org/family/PF01915 Pfam PF14310 http://pfam.xfam.org/family/PF14310 Phobius swissprot:BGLX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BGLX_ECOLI PhylomeDB P33363 http://phylomedb.org/?seqid=P33363 ProteinModelPortal P33363 http://www.proteinmodelportal.org/query/uniprot/P33363 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416636 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416636 RefSeq WP_000871504 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000871504 SMART SM01217 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01217 SMR P33363 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33363 STRING 511145.b2132 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2132&targetmode=cogs STRING COG1472 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1472&targetmode=cogs SUPFAM SSF51445 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51445 SUPFAM SSF52279 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52279 UniProtKB BGLX_ECOLI http://www.uniprot.org/uniprot/BGLX_ECOLI UniProtKB-AC P33363 http://www.uniprot.org/uniprot/P33363 charge swissprot:BGLX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BGLX_ECOLI eggNOG COG1472 http://eggnogapi.embl.de/nog_data/html/tree/COG1472 eggNOG ENOG4107QK4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QK4 epestfind swissprot:BGLX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BGLX_ECOLI garnier swissprot:BGLX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BGLX_ECOLI helixturnhelix swissprot:BGLX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BGLX_ECOLI hmoment swissprot:BGLX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BGLX_ECOLI iep swissprot:BGLX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BGLX_ECOLI inforesidue swissprot:BGLX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BGLX_ECOLI octanol swissprot:BGLX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BGLX_ECOLI pepcoil swissprot:BGLX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BGLX_ECOLI pepdigest swissprot:BGLX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BGLX_ECOLI pepinfo swissprot:BGLX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BGLX_ECOLI pepnet swissprot:BGLX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BGLX_ECOLI pepstats swissprot:BGLX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BGLX_ECOLI pepwheel swissprot:BGLX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BGLX_ECOLI pepwindow swissprot:BGLX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BGLX_ECOLI sigcleave swissprot:BGLX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BGLX_ECOLI ## Database ID URL or Descriptions # BioGrid 4262252 14 # EcoGene EG13212 yfjZ # FUNCTION YFJZ_ECOLI Might be an antitoxin component of a toxin-antitoxin (TA) module. A putative antitoxin that may inactivate probable toxin YpjF (Potential). {ECO 0000305}. # InterPro IPR009320 YagB_YeeU_YfjZ # Organism YFJZ_ECOLI Escherichia coli (strain K12) # PATRIC 32120685 VBIEscCol129921_2741 # PDB 2EA9 X-ray; 2.10 A; A=1-105 # PDB 2JN7 NMR; -; A=1-105 # PIR T08656 T08656 # Pfam PF06154 CbeA_antitoxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFJZ_ECOLI Putative antitoxin YfjZ # RefSeq NP_417132 NC_000913.3 # RefSeq WP_000072690 NZ_LN832404.1 # SIMILARITY Belongs to the CbeA/YafW/YfjZ antitoxin family. {ECO 0000305}. # eggNOG ENOG4105MAW Bacteria # eggNOG ENOG4111V4B LUCA BLAST swissprot:YFJZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFJZ_ECOLI BioCyc ECOL316407:JW2626-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2626-MONOMER BioCyc EcoCyc:G7380-MONOMER http://biocyc.org/getid?id=EcoCyc:G7380-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36840 http://www.ebi.ac.uk/ena/data/view/U36840 EchoBASE EB3004 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3004 EcoGene EG13212 http://www.ecogene.org/geneInfo.php?eg_id=EG13212 EnsemblBacteria AAC75693 http://www.ensemblgenomes.org/id/AAC75693 EnsemblBacteria AAC75693 http://www.ensemblgenomes.org/id/AAC75693 EnsemblBacteria BAA16513 http://www.ensemblgenomes.org/id/BAA16513 EnsemblBacteria BAA16513 http://www.ensemblgenomes.org/id/BAA16513 EnsemblBacteria BAA16513 http://www.ensemblgenomes.org/id/BAA16513 EnsemblBacteria b2645 http://www.ensemblgenomes.org/id/b2645 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947123 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947123 HOGENOM HOG000290944 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000290944&db=HOGENOM6 IntAct P52141 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P52141* InterPro IPR009320 http://www.ebi.ac.uk/interpro/entry/IPR009320 KEGG_Gene ecj:JW2626 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2626 KEGG_Gene eco:b2645 http://www.genome.jp/dbget-bin/www_bget?eco:b2645 OMA HDGFTCE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HDGFTCE PDB 2EA9 http://www.ebi.ac.uk/pdbe-srv/view/entry/2EA9 PDB 2JN7 http://www.ebi.ac.uk/pdbe-srv/view/entry/2JN7 PDBsum 2EA9 http://www.ebi.ac.uk/pdbsum/2EA9 PDBsum 2JN7 http://www.ebi.ac.uk/pdbsum/2JN7 PSORT swissprot:YFJZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFJZ_ECOLI PSORT-B swissprot:YFJZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFJZ_ECOLI PSORT2 swissprot:YFJZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFJZ_ECOLI Pfam PF06154 http://pfam.xfam.org/family/PF06154 Phobius swissprot:YFJZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFJZ_ECOLI PhylomeDB P52141 http://phylomedb.org/?seqid=P52141 ProteinModelPortal P52141 http://www.proteinmodelportal.org/query/uniprot/P52141 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417132 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417132 RefSeq WP_000072690 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000072690 SMR P52141 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P52141 STRING 511145.b2645 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2645&targetmode=cogs UniProtKB YFJZ_ECOLI http://www.uniprot.org/uniprot/YFJZ_ECOLI UniProtKB-AC P52141 http://www.uniprot.org/uniprot/P52141 charge swissprot:YFJZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFJZ_ECOLI eggNOG ENOG4105MAW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105MAW eggNOG ENOG4111V4B http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111V4B epestfind swissprot:YFJZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFJZ_ECOLI garnier swissprot:YFJZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFJZ_ECOLI helixturnhelix swissprot:YFJZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFJZ_ECOLI hmoment swissprot:YFJZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFJZ_ECOLI iep swissprot:YFJZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFJZ_ECOLI inforesidue swissprot:YFJZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFJZ_ECOLI octanol swissprot:YFJZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFJZ_ECOLI pepcoil swissprot:YFJZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFJZ_ECOLI pepdigest swissprot:YFJZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFJZ_ECOLI pepinfo swissprot:YFJZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFJZ_ECOLI pepnet swissprot:YFJZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFJZ_ECOLI pepstats swissprot:YFJZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFJZ_ECOLI pepwheel swissprot:YFJZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFJZ_ECOLI pepwindow swissprot:YFJZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFJZ_ECOLI sigcleave swissprot:YFJZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFJZ_ECOLI ## Database ID URL or Descriptions # Gene3D 1.10.3530.10 -; 1. # InterPro IPR009694 DUF1281 # InterPro IPR023136 Api92-like_domain # Organism YUBA_ECOLI Escherichia coli (strain K12) # Pfam PF06924 DUF1281 # RecName YUBA_ECOLI Uncharacterized protein YubA # RefSeq NP_061428 NC_002483.1 # RefSeq WP_001443029 NC_002483.1 BLAST swissprot:YUBA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YUBA_ECOLI DOI 10.1006/plas.1999.1390 http://dx.doi.org/10.1006/plas.1999.1390 EMBL AF106329 http://www.ebi.ac.uk/ena/data/view/AF106329 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 1.10.3530.10 http://www.cathdb.info/version/latest/superfamily/1.10.3530.10 GeneID 1263495 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263495 InterPro IPR009694 http://www.ebi.ac.uk/interpro/entry/IPR009694 InterPro IPR023136 http://www.ebi.ac.uk/interpro/entry/IPR023136 OMA RRWVRCT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RRWVRCT PSORT swissprot:YUBA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YUBA_ECOLI PSORT-B swissprot:YUBA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YUBA_ECOLI PSORT2 swissprot:YUBA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YUBA_ECOLI Pfam PF06924 http://pfam.xfam.org/family/PF06924 Phobius swissprot:YUBA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YUBA_ECOLI ProteinModelPortal Q9S4X5 http://www.proteinmodelportal.org/query/uniprot/Q9S4X5 PubMed 10366527 http://www.ncbi.nlm.nih.gov/pubmed/10366527 RefSeq NP_061428 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061428 RefSeq WP_001443029 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001443029 SMR Q9S4X5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9S4X5 UniProtKB YUBA_ECOLI http://www.uniprot.org/uniprot/YUBA_ECOLI UniProtKB-AC Q9S4X5 http://www.uniprot.org/uniprot/Q9S4X5 charge swissprot:YUBA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YUBA_ECOLI epestfind swissprot:YUBA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YUBA_ECOLI garnier swissprot:YUBA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YUBA_ECOLI helixturnhelix swissprot:YUBA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YUBA_ECOLI hmoment swissprot:YUBA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YUBA_ECOLI iep swissprot:YUBA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YUBA_ECOLI inforesidue swissprot:YUBA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YUBA_ECOLI octanol swissprot:YUBA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YUBA_ECOLI pepcoil swissprot:YUBA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YUBA_ECOLI pepdigest swissprot:YUBA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YUBA_ECOLI pepinfo swissprot:YUBA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YUBA_ECOLI pepnet swissprot:YUBA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YUBA_ECOLI pepstats swissprot:YUBA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YUBA_ECOLI pepwheel swissprot:YUBA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YUBA_ECOLI pepwindow swissprot:YUBA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YUBA_ECOLI sigcleave swissprot:YUBA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YUBA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261381 5 # EcoGene EG12171 yjjI # IntAct P37342 3 # InterPro IPR016905 Glycyl_radical_HI0521_prd # Organism YJJI_ECOLI Escherichia coli (strain K12) # PATRIC 32124374 VBIEscCol129921_4527 # PIR S56604 S56604 # PIRSF PIRSF028991 Glycl_rad_HI0521_prd # Pfam PF11230 DUF3029 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJJI_ECOLI Uncharacterized protein YjjI # RefSeq NP_418797 NC_000913.3 # RefSeq WP_001143253 NZ_LN832404.1 # SIMILARITY To H.influenzae HI_0521. {ECO 0000305}. # TIGRFAMs TIGR04040 glycyl_YjjI # eggNOG ENOG4105G0K Bacteria # eggNOG ENOG410XNMQ LUCA BLAST swissprot:YJJI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJJI_ECOLI BioCyc ECOL316407:JW4343-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4343-MONOMER BioCyc EcoCyc:EG12171-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12171-MONOMER DIP DIP-12653N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12653N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X03224 http://www.ebi.ac.uk/ena/data/view/X03224 EMBL X04151 http://www.ebi.ac.uk/ena/data/view/X04151 EchoBASE EB2089 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2089 EcoGene EG12171 http://www.ecogene.org/geneInfo.php?eg_id=EG12171 EnsemblBacteria AAC77333 http://www.ensemblgenomes.org/id/AAC77333 EnsemblBacteria AAC77333 http://www.ensemblgenomes.org/id/AAC77333 EnsemblBacteria BAE78369 http://www.ensemblgenomes.org/id/BAE78369 EnsemblBacteria BAE78369 http://www.ensemblgenomes.org/id/BAE78369 EnsemblBacteria BAE78369 http://www.ensemblgenomes.org/id/BAE78369 EnsemblBacteria b4380 http://www.ensemblgenomes.org/id/b4380 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 948904 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948904 HOGENOM HOG000271695 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000271695&db=HOGENOM6 IntAct P37342 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37342* InterPro IPR016905 http://www.ebi.ac.uk/interpro/entry/IPR016905 KEGG_Gene ecj:JW4343 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4343 KEGG_Gene eco:b4380 http://www.genome.jp/dbget-bin/www_bget?eco:b4380 MINT MINT-1246818 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1246818 OMA TIIYHHV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TIIYHHV PSORT swissprot:YJJI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJJI_ECOLI PSORT-B swissprot:YJJI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJJI_ECOLI PSORT2 swissprot:YJJI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJJI_ECOLI Pfam PF11230 http://pfam.xfam.org/family/PF11230 Phobius swissprot:YJJI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJJI_ECOLI ProteinModelPortal P37342 http://www.proteinmodelportal.org/query/uniprot/P37342 PubMed 16453417 http://www.ncbi.nlm.nih.gov/pubmed/16453417 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3019678 http://www.ncbi.nlm.nih.gov/pubmed/3019678 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418797 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418797 RefSeq WP_001143253 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001143253 STRING 511145.b4380 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4380&targetmode=cogs TIGRFAMs TIGR04040 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR04040 UniProtKB YJJI_ECOLI http://www.uniprot.org/uniprot/YJJI_ECOLI UniProtKB-AC P37342 http://www.uniprot.org/uniprot/P37342 charge swissprot:YJJI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJJI_ECOLI eggNOG ENOG4105G0K http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105G0K eggNOG ENOG410XNMQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNMQ epestfind swissprot:YJJI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJJI_ECOLI garnier swissprot:YJJI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJJI_ECOLI helixturnhelix swissprot:YJJI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJJI_ECOLI hmoment swissprot:YJJI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJJI_ECOLI iep swissprot:YJJI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJJI_ECOLI inforesidue swissprot:YJJI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJJI_ECOLI octanol swissprot:YJJI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJJI_ECOLI pepcoil swissprot:YJJI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJJI_ECOLI pepdigest swissprot:YJJI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJJI_ECOLI pepinfo swissprot:YJJI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJJI_ECOLI pepnet swissprot:YJJI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJJI_ECOLI pepstats swissprot:YJJI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJJI_ECOLI pepwheel swissprot:YJJI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJJI_ECOLI pepwindow swissprot:YJJI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJJI_ECOLI sigcleave swissprot:YJJI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJJI_ECOLI ## Database ID URL or Descriptions # BioGrid 4259728 225 # EcoGene EG11571 yabI # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0010212 response to ionizing radiation; IMP:EcoCyc. # GO_process GO:0043093 FtsZ-dependent cytokinesis; IGI:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0008150 biological_process # InterPro IPR032816 SNARE_assoc # InterPro IPR032818 DedA # Organism YABI_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30353 PTHR30353 # PATRIC 32115231 VBIEscCol129921_0067 # PIR A64728 A64728 # Pfam PF09335 SNARE_assoc # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YABI_ECOLI Inner membrane protein YabI # RefSeq NP_414607 NC_000913.3 # RefSeq WP_001148390 NZ_LN832404.1 # SIMILARITY Belongs to the DedA family. {ECO 0000305}. # SUBCELLULAR LOCATION YABI_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG COG0586 LUCA # eggNOG ENOG4108KF1 Bacteria BLAST swissprot:YABI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YABI_ECOLI BioCyc ECOL316407:JW5005-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5005-MONOMER BioCyc EcoCyc:EG11571-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11571-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1531 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1531 EcoGene EG11571 http://www.ecogene.org/geneInfo.php?eg_id=EG11571 EnsemblBacteria AAC73176 http://www.ensemblgenomes.org/id/AAC73176 EnsemblBacteria AAC73176 http://www.ensemblgenomes.org/id/AAC73176 EnsemblBacteria BAB96634 http://www.ensemblgenomes.org/id/BAB96634 EnsemblBacteria BAB96634 http://www.ensemblgenomes.org/id/BAB96634 EnsemblBacteria BAB96634 http://www.ensemblgenomes.org/id/BAB96634 EnsemblBacteria b0065 http://www.ensemblgenomes.org/id/b0065 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0010212 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010212 GO_process GO:0043093 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043093 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 944783 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944783 HOGENOM HOG000116766 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000116766&db=HOGENOM6 InParanoid P30149 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30149 InterPro IPR032816 http://www.ebi.ac.uk/interpro/entry/IPR032816 InterPro IPR032818 http://www.ebi.ac.uk/interpro/entry/IPR032818 KEGG_Gene ecj:JW5005 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5005 KEGG_Gene eco:b0065 http://www.genome.jp/dbget-bin/www_bget?eco:b0065 OMA LPPYKFA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LPPYKFA PANTHER PTHR30353 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30353 PSORT swissprot:YABI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YABI_ECOLI PSORT-B swissprot:YABI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YABI_ECOLI PSORT2 swissprot:YABI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YABI_ECOLI Pfam PF09335 http://pfam.xfam.org/family/PF09335 Phobius swissprot:YABI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YABI_ECOLI PhylomeDB P30149 http://phylomedb.org/?seqid=P30149 ProteinModelPortal P30149 http://www.proteinmodelportal.org/query/uniprot/P30149 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414607 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414607 RefSeq WP_001148390 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001148390 STRING 511145.b0065 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0065&targetmode=cogs UniProtKB YABI_ECOLI http://www.uniprot.org/uniprot/YABI_ECOLI UniProtKB-AC P30149 http://www.uniprot.org/uniprot/P30149 charge swissprot:YABI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YABI_ECOLI eggNOG COG0586 http://eggnogapi.embl.de/nog_data/html/tree/COG0586 eggNOG ENOG4108KF1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108KF1 epestfind swissprot:YABI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YABI_ECOLI garnier swissprot:YABI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YABI_ECOLI helixturnhelix swissprot:YABI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YABI_ECOLI hmoment swissprot:YABI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YABI_ECOLI iep swissprot:YABI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YABI_ECOLI inforesidue swissprot:YABI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YABI_ECOLI octanol swissprot:YABI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YABI_ECOLI pepcoil swissprot:YABI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YABI_ECOLI pepdigest swissprot:YABI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YABI_ECOLI pepinfo swissprot:YABI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YABI_ECOLI pepnet swissprot:YABI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YABI_ECOLI pepstats swissprot:YABI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YABI_ECOLI pepwheel swissprot:YABI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YABI_ECOLI pepwindow swissprot:YABI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YABI_ECOLI sigcleave swissprot:YABI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YABI_ECOLI ## Database ID URL or Descriptions # BioGrid 4263253 11 # COFACTOR EFEB_ECOLI Name=heme b; Xref=ChEBI CHEBI 60344; Evidence={ECO 0000269|PubMed 16551627}; Note=Binds 1 heme b (iron(II)-protoporphyrin IX) group non- covalently per subunit. {ECO 0000269|PubMed 16551627}; # EcoGene EG11735 efeB # FUNCTION EFEB_ECOLI Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact. Also displays peroxidase activity on guaiacol in vitro. {ECO 0000269|PubMed 16551627, ECO 0000269|PubMed 19564607}. # GO_component GO:0042597 periplasmic space; IDA:EcoliWiki. # GO_function GO:0004601 peroxidase activity; IDA:EcoliWiki. # GO_function GO:0016675 oxidoreductase activity, acting on a heme group of donors; IDA:EcoCyc. # GO_function GO:0020037 heme binding; IDA:EcoliWiki. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0015684 ferrous iron transport; IEA:InterPro. # GO_process GO:0033212 iron assimilation; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # GOslim_process GO:0006950 response to stress # GOslim_process GO:0042592 homeostatic process # INDUCTION EFEB_ECOLI Repressed by Fur in the presence of iron. Repressed at high pH by the two-component regulatory system CpxA/CpxR. {ECO 0000269|PubMed 12746439, ECO 0000269|PubMed 17627767}. # IntAct P31545 8 # InterPro IPR006311 TAT_signal # InterPro IPR006313 EfeB # InterPro IPR006314 Dyp_peroxidase # InterPro IPR011008 Dimeric_a/b-barrel # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 Transporters # MASS SPECTROMETRY Mass=43814; Method=Electrospray; Range=36-423; Evidence={ECO:0000269|PubMed 16551627}; # Organism EFEB_ECOLI Escherichia coli (strain K12) # PATRIC 32117271 VBIEscCol129921_1059 # PDB 2Y4D X-ray; 2.00 A; A/B=36-423 # PDB 2Y4E X-ray; 2.30 A; A/B=36-423 # PDB 2Y4F X-ray; 2.70 A; A/B=36-423 # PIR A64844 A64844 # PROSITE PS51318 TAT # PROSITE PS51404 DYP_PEROXIDASE # PTM EFEB_ECOLI Exported by the Tat system. The position of the signal peptide cleavage has been experimentally proven. Can also be exported by the Sec system. # PeroxiBase 5870 EcoDyPrx01_K12 # Pfam PF04261 Dyp_perox # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EFEB_ECOLI Deferrochelatase/peroxidase EfeB # RefSeq NP_415538 NC_000913.3 # RefSeq WP_001199471 NZ_LN832404.1 # SIMILARITY Belongs to the DyP-type peroxidase family. EfeB subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION EFEB_ECOLI Periplasm {ECO 0000269|PubMed 16551627}. # SUBUNIT EFEB_ECOLI Homodimer. Part of a ferrous iron transporter composed of EfeU, EfeO and EfeB. However, this EfeUOB tripartite iron transporter is defective in E.coli strain K12 due to a frameshift mutation in EfeU. {ECO 0000269|PubMed 16551627, ECO 0000269|PubMed 17627767, ECO 0000269|Ref.11}. # SUPFAM SSF54909 SSF54909 # TCDB 2.A.108.2 the iron/lead transporter (ilt) family # TIGRFAMs TIGR01412 tat_substr_1 # TIGRFAMs TIGR01413 Dyp_perox_fam # eggNOG COG2837 LUCA # eggNOG ENOG4105DBE Bacteria BLAST swissprot:EFEB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EFEB_ECOLI BioCyc ECOL316407:JW1004-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1004-MONOMER BioCyc EcoCyc:EG11735-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11735-MONOMER BioCyc MetaCyc:EG11735-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11735-MONOMER COG COG2837 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2837 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0903842106 http://dx.doi.org/10.1073/pnas.0903842106 DOI 10.1074/jbc.M303381200 http://dx.doi.org/10.1074/jbc.M303381200 DOI 10.1074/jbc.M511891200 http://dx.doi.org/10.1074/jbc.M511891200 DOI 10.1074/jbc.M610507200 http://dx.doi.org/10.1074/jbc.M610507200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1107/S174430910604509X http://dx.doi.org/10.1107/S174430910604509X DOI 10.1111/j.1365-2958.2007.05802.x http://dx.doi.org/10.1111/j.1365-2958.2007.05802.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.11.1.- http://www.genome.jp/dbget-bin/www_bget?EC:1.11.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D10391 http://www.ebi.ac.uk/ena/data/view/D10391 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.11.1.- http://enzyme.expasy.org/EC/1.11.1.- EchoBASE EB1686 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1686 EcoGene EG11735 http://www.ecogene.org/geneInfo.php?eg_id=EG11735 EnsemblBacteria AAC74104 http://www.ensemblgenomes.org/id/AAC74104 EnsemblBacteria AAC74104 http://www.ensemblgenomes.org/id/AAC74104 EnsemblBacteria BAA35800 http://www.ensemblgenomes.org/id/BAA35800 EnsemblBacteria BAA35800 http://www.ensemblgenomes.org/id/BAA35800 EnsemblBacteria BAA35800 http://www.ensemblgenomes.org/id/BAA35800 EnsemblBacteria b1019 http://www.ensemblgenomes.org/id/b1019 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0004601 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004601 GO_function GO:0016675 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016675 GO_function GO:0020037 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0020037 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0015684 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015684 GO_process GO:0033212 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033212 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GeneID 946500 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946500 HOGENOM HOG000236941 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000236941&db=HOGENOM6 InParanoid P31545 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31545 IntAct P31545 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31545* IntEnz 1.11.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.11.1 InterPro IPR006311 http://www.ebi.ac.uk/interpro/entry/IPR006311 InterPro IPR006313 http://www.ebi.ac.uk/interpro/entry/IPR006313 InterPro IPR006314 http://www.ebi.ac.uk/interpro/entry/IPR006314 InterPro IPR011008 http://www.ebi.ac.uk/interpro/entry/IPR011008 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1004 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1004 KEGG_Gene eco:b1019 http://www.genome.jp/dbget-bin/www_bget?eco:b1019 KEGG_Orthology KO:K16301 http://www.genome.jp/dbget-bin/www_bget?KO:K16301 OMA VERWDRT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VERWDRT PDB 2Y4D http://www.ebi.ac.uk/pdbe-srv/view/entry/2Y4D PDB 2Y4E http://www.ebi.ac.uk/pdbe-srv/view/entry/2Y4E PDB 2Y4F http://www.ebi.ac.uk/pdbe-srv/view/entry/2Y4F PDBsum 2Y4D http://www.ebi.ac.uk/pdbsum/2Y4D PDBsum 2Y4E http://www.ebi.ac.uk/pdbsum/2Y4E PDBsum 2Y4F http://www.ebi.ac.uk/pdbsum/2Y4F PROSITE PS51318 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51318 PROSITE PS51404 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51404 PSORT swissprot:EFEB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EFEB_ECOLI PSORT-B swissprot:EFEB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EFEB_ECOLI PSORT2 swissprot:EFEB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EFEB_ECOLI PeroxiBase 5870 http://peroxibase.toulouse.inra.fr/listing.php?action=view&id=5870 Pfam PF04261 http://pfam.xfam.org/family/PF04261 Phobius swissprot:EFEB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EFEB_ECOLI PhylomeDB P31545 http://phylomedb.org/?seqid=P31545 ProteinModelPortal P31545 http://www.proteinmodelportal.org/query/uniprot/P31545 PubMed 12746439 http://www.ncbi.nlm.nih.gov/pubmed/12746439 PubMed 16551627 http://www.ncbi.nlm.nih.gov/pubmed/16551627 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17183171 http://www.ncbi.nlm.nih.gov/pubmed/17183171 PubMed 17218314 http://www.ncbi.nlm.nih.gov/pubmed/17218314 PubMed 17627767 http://www.ncbi.nlm.nih.gov/pubmed/17627767 PubMed 19564607 http://www.ncbi.nlm.nih.gov/pubmed/19564607 PubMed 8444794 http://www.ncbi.nlm.nih.gov/pubmed/8444794 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415538 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415538 RefSeq WP_001199471 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001199471 SMR P31545 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31545 STRING 511145.b1019 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1019&targetmode=cogs STRING COG2837 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2837&targetmode=cogs SUPFAM SSF54909 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54909 TCDB 2.A.108.2 http://www.tcdb.org/search/result.php?tc=2.A.108.2 TIGRFAMs TIGR01412 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01412 TIGRFAMs TIGR01413 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01413 UniProtKB EFEB_ECOLI http://www.uniprot.org/uniprot/EFEB_ECOLI UniProtKB-AC P31545 http://www.uniprot.org/uniprot/P31545 charge swissprot:EFEB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EFEB_ECOLI eggNOG COG2837 http://eggnogapi.embl.de/nog_data/html/tree/COG2837 eggNOG ENOG4105DBE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DBE epestfind swissprot:EFEB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EFEB_ECOLI garnier swissprot:EFEB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EFEB_ECOLI helixturnhelix swissprot:EFEB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EFEB_ECOLI hmoment swissprot:EFEB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EFEB_ECOLI iep swissprot:EFEB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EFEB_ECOLI inforesidue swissprot:EFEB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EFEB_ECOLI octanol swissprot:EFEB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EFEB_ECOLI pepcoil swissprot:EFEB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EFEB_ECOLI pepdigest swissprot:EFEB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EFEB_ECOLI pepinfo swissprot:EFEB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EFEB_ECOLI pepnet swissprot:EFEB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EFEB_ECOLI pepstats swissprot:EFEB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EFEB_ECOLI pepwheel swissprot:EFEB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EFEB_ECOLI pepwindow swissprot:EFEB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EFEB_ECOLI sigcleave swissprot:EFEB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EFEB_ECOLI ## Database ID URL or Descriptions # DISRUPTION PHENOTYPE During aerobic growth, mutant is impaired for ubiquinone biosynthesis and for growth in rich medium, but it does not present any defect under anaerobic conditions. {ECO:0000269|PubMed 24142253}. # EcoGene EG11474 ubiJ # FUNCTION UBIJ_ECOLI Involved in ubiquinone (coenzyme Q) biosynthesis under aerobic conditions. {ECO 0000269|PubMed 24142253}. # GO_process GO:0032150 ubiquinone biosynthetic process from chorismate; IMP:EcoCyc. # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # InterPro IPR003033 SCP2_sterol-bd_dom # Organism UBIJ_ECOLI Escherichia coli (strain K12) # PATHWAY Cofactor biosynthesis; ubiquinone biosynthesis. {ECO:0000269|PubMed 24142253}. # PATRIC 32123169 VBIEscCol129921_3950 # PIR C65188 C65188 # Pfam PF02036 SCP2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Ubiquinone biosynthesis protein UbiJ {ECO 0000305} # RefSeq NP_418278 NC_000913.3 # RefSeq WP_001295259 NZ_LN832404.1 # SIMILARITY Belongs to the UbiJ family. {ECO 0000305}. # SUPFAM SSF55718 SSF55718 # eggNOG COG3165 LUCA # eggNOG ENOG4105JC1 Bacteria BLAST swissprot:UBIJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UBIJ_ECOLI BioCyc ECOL316407:JW3811-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3811-MONOMER BioCyc EcoCyc:EG11474-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11474-MONOMER COG COG3165 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3165 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01065-13 http://dx.doi.org/10.1128/JB.01065-13 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1442 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1442 EcoGene EG11474 http://www.ecogene.org/geneInfo.php?eg_id=EG11474 EnsemblBacteria AAC76837 http://www.ensemblgenomes.org/id/AAC76837 EnsemblBacteria AAC76837 http://www.ensemblgenomes.org/id/AAC76837 EnsemblBacteria BAE77467 http://www.ensemblgenomes.org/id/BAE77467 EnsemblBacteria BAE77467 http://www.ensemblgenomes.org/id/BAE77467 EnsemblBacteria BAE77467 http://www.ensemblgenomes.org/id/BAE77467 EnsemblBacteria b3834 http://www.ensemblgenomes.org/id/b3834 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0032150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GeneID 948915 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948915 HOGENOM HOG000269583 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000269583&db=HOGENOM6 IntAct P0ADP7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADP7* InterPro IPR003033 http://www.ebi.ac.uk/interpro/entry/IPR003033 KEGG_Gene ecj:JW3811 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3811 KEGG_Gene eco:b3834 http://www.genome.jp/dbget-bin/www_bget?eco:b3834 KEGG_Orthology KO:K03690 http://www.genome.jp/dbget-bin/www_bget?KO:K03690 OMA APYIGDI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=APYIGDI PSORT swissprot:UBIJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UBIJ_ECOLI PSORT-B swissprot:UBIJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UBIJ_ECOLI PSORT2 swissprot:UBIJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UBIJ_ECOLI Pfam PF02036 http://pfam.xfam.org/family/PF02036 Phobius swissprot:UBIJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UBIJ_ECOLI ProteinModelPortal P0ADP7 http://www.proteinmodelportal.org/query/uniprot/P0ADP7 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 24142253 http://www.ncbi.nlm.nih.gov/pubmed/24142253 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418278 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418278 RefSeq WP_001295259 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295259 STRING 511145.b3834 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3834&targetmode=cogs STRING COG3165 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3165&targetmode=cogs SUPFAM SSF55718 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55718 UniProtKB UBIJ_ECOLI http://www.uniprot.org/uniprot/UBIJ_ECOLI UniProtKB-AC P0ADP7 http://www.uniprot.org/uniprot/P0ADP7 charge swissprot:UBIJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UBIJ_ECOLI eggNOG COG3165 http://eggnogapi.embl.de/nog_data/html/tree/COG3165 eggNOG ENOG4105JC1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105JC1 epestfind swissprot:UBIJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UBIJ_ECOLI garnier swissprot:UBIJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UBIJ_ECOLI helixturnhelix swissprot:UBIJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UBIJ_ECOLI hmoment swissprot:UBIJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UBIJ_ECOLI iep swissprot:UBIJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UBIJ_ECOLI inforesidue swissprot:UBIJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UBIJ_ECOLI octanol swissprot:UBIJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UBIJ_ECOLI pepcoil swissprot:UBIJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UBIJ_ECOLI pepdigest swissprot:UBIJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UBIJ_ECOLI pepinfo swissprot:UBIJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UBIJ_ECOLI pepnet swissprot:UBIJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UBIJ_ECOLI pepstats swissprot:UBIJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UBIJ_ECOLI pepwheel swissprot:UBIJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UBIJ_ECOLI pepwindow swissprot:UBIJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UBIJ_ECOLI sigcleave swissprot:UBIJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UBIJ_ECOLI ## Database ID URL or Descriptions # AltName LEUD_ECOLI Alpha-IPM isomerase # AltName LEUD_ECOLI Isopropylmalate isomerase # BioGrid 4262049 4 # CATALYTIC ACTIVITY LEUD_ECOLI (2R,3S)-3-isopropylmalate = (2S)-2- isopropylmalate. # CDD cd01577 IPMI_Swivel # EcoGene EG11575 leuD # FUNCTION LEUD_ECOLI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0009316 3-isopropylmalate dehydratase complex; IMP:EcoliWiki. # GO_function GO:0003861 3-isopropylmalate dehydratase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0016866 intramolecular transferase activity; IDA:EcoCyc. # GO_process GO:0009082 branched-chain amino acid biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0009098 leucine biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.20.19.10 -; 1. # HAMAP MF_01031 LeuD_type1 # INTERACTION LEUD_ECOLI P0A6A6 leuC; NbExp=4; IntAct=EBI-1113528, EBI-1113576; # IntAct P30126 6 # InterPro IPR000573 AconitaseA/IPMdHydase_ssu_swvl # InterPro IPR004431 3-IsopropMal_deHydase_ssu # InterPro IPR015928 Aconitase/3IPM_dehydase_swvl # InterPro IPR015937 Acoase/IPM_deHydtase # InterPro IPR033940 IPMI_Swivel # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00290 Valine, leucine and isoleucine biosynthesis # KEGG_Pathway ko00660 C5-Branched dibasic acid metabolism # Organism LEUD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11670 PTHR11670 # PATHWAY Amino-acid biosynthesis; L-leucine biosynthesis; L- leucine from 3-methyl-2-oxobutanoate step 2/4. # PATRIC 32115245 VBIEscCol129921_0074 # PIR S40585 S40585 # Pfam PF00694 Aconitase_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LEUD_ECOLI 3-isopropylmalate dehydratase small subunit # RefSeq NP_414613 NC_000913.3 # RefSeq WP_000818228 NZ_LN832404.1 # SIMILARITY Belongs to the LeuD family. LeuD type 1 subfamily. {ECO 0000305}. # SUBUNIT Heterodimer of LeuC and LeuD. {ECO 0000250}. # SUPFAM SSF52016 SSF52016 # TIGRFAMs TIGR00171 leuD # UniPathway UPA00048 UER00071 # eggNOG COG0066 LUCA # eggNOG ENOG4105MQS Bacteria BLAST swissprot:LEUD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LEUD_ECOLI BioCyc ECOL316407:JW0070-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0070-MONOMER BioCyc EcoCyc:LEUD-MONOMER http://biocyc.org/getid?id=EcoCyc:LEUD-MONOMER BioCyc MetaCyc:LEUD-MONOMER http://biocyc.org/getid?id=MetaCyc:LEUD-MONOMER COG COG0066 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0066 DIP DIP-10092N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10092N DOI 10.1006/jmbi.1998.1726 http://dx.doi.org/10.1006/jmbi.1998.1726 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.1.33 http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.33 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 4.2.1.33 http://enzyme.expasy.org/EC/4.2.1.33 EchoBASE EB1535 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1535 EcoGene EG11575 http://www.ecogene.org/geneInfo.php?eg_id=EG11575 EnsemblBacteria AAC73182 http://www.ensemblgenomes.org/id/AAC73182 EnsemblBacteria AAC73182 http://www.ensemblgenomes.org/id/AAC73182 EnsemblBacteria BAB96640 http://www.ensemblgenomes.org/id/BAB96640 EnsemblBacteria BAB96640 http://www.ensemblgenomes.org/id/BAB96640 EnsemblBacteria BAB96640 http://www.ensemblgenomes.org/id/BAB96640 EnsemblBacteria b0071 http://www.ensemblgenomes.org/id/b0071 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0009316 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009316 GO_function GO:0003861 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003861 GO_function GO:0016866 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016866 GO_process GO:0009082 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009082 GO_process GO:0009098 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009098 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.20.19.10 http://www.cathdb.info/version/latest/superfamily/3.20.19.10 GeneID 945642 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945642 HAMAP MF_01031 http://hamap.expasy.org/unirule/MF_01031 HOGENOM HOG000222939 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000222939&db=HOGENOM6 InParanoid P30126 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30126 IntAct P30126 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P30126* IntEnz 4.2.1.33 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.33 InterPro IPR000573 http://www.ebi.ac.uk/interpro/entry/IPR000573 InterPro IPR004431 http://www.ebi.ac.uk/interpro/entry/IPR004431 InterPro IPR015928 http://www.ebi.ac.uk/interpro/entry/IPR015928 InterPro IPR015937 http://www.ebi.ac.uk/interpro/entry/IPR015937 InterPro IPR033940 http://www.ebi.ac.uk/interpro/entry/IPR033940 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0070 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0070 KEGG_Gene eco:b0071 http://www.genome.jp/dbget-bin/www_bget?eco:b0071 KEGG_Orthology KO:K01704 http://www.genome.jp/dbget-bin/www_bget?KO:K01704 KEGG_Pathway ko00290 http://www.genome.jp/kegg-bin/show_pathway?ko00290 KEGG_Pathway ko00660 http://www.genome.jp/kegg-bin/show_pathway?ko00660 KEGG_Reaction rn:R03896 http://www.genome.jp/dbget-bin/www_bget?rn:R03896 KEGG_Reaction rn:R03898 http://www.genome.jp/dbget-bin/www_bget?rn:R03898 KEGG_Reaction rn:R03968 http://www.genome.jp/dbget-bin/www_bget?rn:R03968 KEGG_Reaction rn:R04001 http://www.genome.jp/dbget-bin/www_bget?rn:R04001 KEGG_Reaction rn:R10170 http://www.genome.jp/dbget-bin/www_bget?rn:R10170 OMA AFTTHTG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AFTTHTG PANTHER PTHR11670 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11670 PSORT swissprot:LEUD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LEUD_ECOLI PSORT-B swissprot:LEUD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LEUD_ECOLI PSORT2 swissprot:LEUD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LEUD_ECOLI Pfam PF00694 http://pfam.xfam.org/family/PF00694 Phobius swissprot:LEUD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LEUD_ECOLI PhylomeDB P30126 http://phylomedb.org/?seqid=P30126 ProteinModelPortal P30126 http://www.proteinmodelportal.org/query/uniprot/P30126 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 RefSeq NP_414613 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414613 RefSeq WP_000818228 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000818228 SMR P30126 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P30126 STRING 511145.b0071 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0071&targetmode=cogs STRING COG0066 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0066&targetmode=cogs SUPFAM SSF52016 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52016 SWISS-2DPAGE P30126 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P30126 TIGRFAMs TIGR00171 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00171 UniProtKB LEUD_ECOLI http://www.uniprot.org/uniprot/LEUD_ECOLI UniProtKB-AC P30126 http://www.uniprot.org/uniprot/P30126 charge swissprot:LEUD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LEUD_ECOLI eggNOG COG0066 http://eggnogapi.embl.de/nog_data/html/tree/COG0066 eggNOG ENOG4105MQS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105MQS epestfind swissprot:LEUD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LEUD_ECOLI garnier swissprot:LEUD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LEUD_ECOLI helixturnhelix swissprot:LEUD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LEUD_ECOLI hmoment swissprot:LEUD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LEUD_ECOLI iep swissprot:LEUD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LEUD_ECOLI inforesidue swissprot:LEUD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LEUD_ECOLI octanol swissprot:LEUD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LEUD_ECOLI pepcoil swissprot:LEUD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LEUD_ECOLI pepdigest swissprot:LEUD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LEUD_ECOLI pepinfo swissprot:LEUD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LEUD_ECOLI pepnet swissprot:LEUD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LEUD_ECOLI pepstats swissprot:LEUD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LEUD_ECOLI pepwheel swissprot:LEUD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LEUD_ECOLI pepwindow swissprot:LEUD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LEUD_ECOLI sigcleave swissprot:LEUD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LEUD_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES HEM6_ECOLI Kinetic parameters KM=2.6 uM for coproporphyrinogen-III (at pH 6 at 37 degrees Celsius) {ECO 0000269|PubMed 12975365, ECO 0000269|PubMed 13129604}; KM=3.1 uM for coproporphyrinogen-III (at pH 7) {ECO 0000269|PubMed 12975365, ECO 0000269|PubMed 13129604}; Vmax=1.3 umol/min/mg enzyme (at pH 6 at 37 degrees Celsius) {ECO 0000269|PubMed 12975365, ECO 0000269|PubMed 13129604}; Note=Kcat is 0.17 min(-1) for decarboxylation of coproporphyrinogen-III (at pH 6 and at 37 degrees Celsius). {ECO 0000269|PubMed 12975365}; pH dependence Optimum pH is between 6 and 7. {ECO 0000269|PubMed 12975365, ECO 0000269|PubMed 13129604}; # BRENDA 1.3.3 2026 # BioGrid 4260574 13 # CATALYTIC ACTIVITY HEM6_ECOLI Coproporphyrinogen-III + O(2) + 2 H(+) = protoporphyrinogen-IX + 2 CO(2) + 2 H(2)O. {ECO 0000255|HAMAP- Rule MF_00333, ECO 0000269|PubMed 12975365, ECO 0000269|PubMed 13129604}. # COFACTOR HEM6_ECOLI Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000255|HAMAP-Rule MF_00333, ECO 0000269|PubMed 12975365}; # ENZYME REGULATION HEM6_ECOLI Inhibited by protoporphyrinogen-IX, by metal chelator (EGTA) and by low concentrations of heavy metal ions. {ECO 0000269|PubMed 12975365, ECO 0000269|PubMed 13129604}. # EcoGene EG12189 hemF # FUNCTION HEM6_ECOLI Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX. {ECO 0000255|HAMAP-Rule MF_00333, ECO 0000269|PubMed 12975365, ECO 0000269|PubMed 13129604}. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_function GO:0004109 coproporphyrinogen oxidase activity; IDA:EcoCyc. # GO_function GO:0030145 manganese ion binding; IDA:EcoCyc. # GO_function GO:0042803 protein homodimerization activity; ISS:UniProtKB. # GO_function GO:0046906 tetrapyrrole binding; IMP:EcoliWiki. # GO_process GO:0006782 protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0006783 heme biosynthetic process; IMP:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.1500.10 -; 1. # HAMAP MF_00333 Coprogen_oxidas # IntAct P36553 3 # InterPro IPR001260 Coprogen_oxidase_aer # InterPro IPR018375 Coprogen_oxidase_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00860 Porphyrin and chlorophyll metabolism # MASS SPECTROMETRY Mass=35390; Method=Electrospray; Range=1-299; Evidence={ECO:0000269|PubMed 13129604}; # Organism HEM6_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10755 PTHR10755 # PATHWAY Porphyrin-containing compound metabolism; protoporphyrin- IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1. {ECO 0000255|HAMAP-Rule:MF_00333}. # PATRIC 32120257 VBIEscCol129921_2531 # PIR B36964 B36964 # PIRSF PIRSF000166 Coproporphyri_ox # PRINTS PR00073 COPRGNOXDASE # PROSITE PS01021 COPROGEN_OXIDASE # Pfam PF01218 Coprogen_oxidas # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Oxygen-dependent coproporphyrinogen-III oxidase {ECO:0000255|HAMAP-Rule MF_00333} # RefSeq NP_416931 NC_000913.3 # RefSeq WP_000801365 NZ_LN832404.1 # SIMILARITY Belongs to the aerobic coproporphyrinogen-III oxidase family. {ECO:0000255|HAMAP-Rule MF_00333}. # SUBCELLULAR LOCATION HEM6_ECOLI Cytoplasm. # SUBUNIT HEM6_ECOLI Homodimer. {ECO 0000255|HAMAP-Rule MF_00333, ECO 0000269|PubMed 12975365, ECO 0000269|PubMed 13129604}. # SUPFAM SSF102886 SSF102886 # UniPathway UPA00251 UER00322 # eggNOG COG0408 LUCA # eggNOG ENOG4105DBS Bacteria BLAST swissprot:HEM6_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HEM6_ECOLI BioCyc ECOL316407:JW2429-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2429-MONOMER BioCyc EcoCyc:COPROGENOXI-MONOMER http://biocyc.org/getid?id=EcoCyc:COPROGENOXI-MONOMER BioCyc MetaCyc:COPROGENOXI-MONOMER http://biocyc.org/getid?id=MetaCyc:COPROGENOXI-MONOMER COG COG0408 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0408 DOI 10.1016/S0378-1097(03)00531-7 http://dx.doi.org/10.1016/S0378-1097(03)00531-7 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M308553200 http://dx.doi.org/10.1074/jbc.M308553200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.3.3.3 {ECO:0000255|HAMAP-Rule:MF_00333} http://www.genome.jp/dbget-bin/www_bget?EC:1.3.3.3 {ECO:0000255|HAMAP-Rule:MF_00333} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X75413 http://www.ebi.ac.uk/ena/data/view/X75413 ENZYME 1.3.3.3 {ECO:0000255|HAMAP-Rule:MF_00333} http://enzyme.expasy.org/EC/1.3.3.3 {ECO:0000255|HAMAP-Rule:MF_00333} EchoBASE EB2106 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2106 EcoGene EG12189 http://www.ecogene.org/geneInfo.php?eg_id=EG12189 EnsemblBacteria AAC75489 http://www.ensemblgenomes.org/id/AAC75489 EnsemblBacteria AAC75489 http://www.ensemblgenomes.org/id/AAC75489 EnsemblBacteria BAA16319 http://www.ensemblgenomes.org/id/BAA16319 EnsemblBacteria BAA16319 http://www.ensemblgenomes.org/id/BAA16319 EnsemblBacteria BAA16319 http://www.ensemblgenomes.org/id/BAA16319 EnsemblBacteria b2436 http://www.ensemblgenomes.org/id/b2436 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004109 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004109 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_function GO:0042803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803 GO_function GO:0046906 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046906 GO_process GO:0006782 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006782 GO_process GO:0006783 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006783 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.1500.10 http://www.cathdb.info/version/latest/superfamily/3.40.1500.10 GeneID 946908 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946908 HAMAP MF_00333 http://hamap.expasy.org/unirule/MF_00333 HOGENOM HOG000262768 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000262768&db=HOGENOM6 InParanoid P36553 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P36553 IntAct P36553 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P36553* IntEnz 1.3.3.3 {ECO:0000255|HAMAP-Rule:MF_00333} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.3.3.3 {ECO:0000255|HAMAP-Rule:MF_00333} InterPro IPR001260 http://www.ebi.ac.uk/interpro/entry/IPR001260 InterPro IPR018375 http://www.ebi.ac.uk/interpro/entry/IPR018375 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2429 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2429 KEGG_Gene eco:b2436 http://www.genome.jp/dbget-bin/www_bget?eco:b2436 KEGG_Orthology KO:K00228 http://www.genome.jp/dbget-bin/www_bget?KO:K00228 KEGG_Pathway ko00860 http://www.genome.jp/kegg-bin/show_pathway?ko00860 KEGG_Reaction rn:R03220 http://www.genome.jp/dbget-bin/www_bget?rn:R03220 OMA IDLTPHY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IDLTPHY PANTHER PTHR10755 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10755 PRINTS PR00073 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00073 PROSITE PS01021 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01021 PSORT swissprot:HEM6_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HEM6_ECOLI PSORT-B swissprot:HEM6_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HEM6_ECOLI PSORT2 swissprot:HEM6_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HEM6_ECOLI Pfam PF01218 http://pfam.xfam.org/family/PF01218 Phobius swissprot:HEM6_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HEM6_ECOLI PhylomeDB P36553 http://phylomedb.org/?seqid=P36553 ProteinModelPortal P36553 http://www.proteinmodelportal.org/query/uniprot/P36553 PubMed 12975365 http://www.ncbi.nlm.nih.gov/pubmed/12975365 PubMed 13129604 http://www.ncbi.nlm.nih.gov/pubmed/13129604 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8300522 http://www.ncbi.nlm.nih.gov/pubmed/8300522 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416931 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416931 RefSeq WP_000801365 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000801365 SMR P36553 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P36553 STRING 511145.b2436 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2436&targetmode=cogs STRING COG0408 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0408&targetmode=cogs SUPFAM SSF102886 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF102886 UniProtKB HEM6_ECOLI http://www.uniprot.org/uniprot/HEM6_ECOLI UniProtKB-AC P36553 http://www.uniprot.org/uniprot/P36553 charge swissprot:HEM6_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HEM6_ECOLI eggNOG COG0408 http://eggnogapi.embl.de/nog_data/html/tree/COG0408 eggNOG ENOG4105DBS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DBS epestfind swissprot:HEM6_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HEM6_ECOLI garnier swissprot:HEM6_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HEM6_ECOLI helixturnhelix swissprot:HEM6_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HEM6_ECOLI hmoment swissprot:HEM6_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HEM6_ECOLI iep swissprot:HEM6_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HEM6_ECOLI inforesidue swissprot:HEM6_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HEM6_ECOLI octanol swissprot:HEM6_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HEM6_ECOLI pepcoil swissprot:HEM6_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HEM6_ECOLI pepdigest swissprot:HEM6_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HEM6_ECOLI pepinfo swissprot:HEM6_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HEM6_ECOLI pepnet swissprot:HEM6_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HEM6_ECOLI pepstats swissprot:HEM6_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HEM6_ECOLI pepwheel swissprot:HEM6_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HEM6_ECOLI pepwindow swissprot:HEM6_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HEM6_ECOLI sigcleave swissprot:HEM6_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HEM6_ECOLI ## Database ID URL or Descriptions # BioGrid 4259271 12 # EcoGene EG12785 yhbP # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0010181 FMN binding; IEA:InterPro. # GO_function GO:0016491 oxidoreductase activity; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # Gene3D 2.30.110.10 -; 1. # HAMAP MF_00764 UPF0306 # IntAct P67762 6 # InterPro IPR011194 UPF0306 # InterPro IPR012349 Split_barrel_FMN-bd # Organism YHBP_ECOLI Escherichia coli (strain K12) # PATRIC 32121726 VBIEscCol129921_3249 # PIR F65105 F65105 # PIRSF PIRSF009554 UCP009554 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHBP_ECOLI UPF0306 protein YhbP # RefSeq NP_417623 NC_000913.3 # RefSeq WP_000449030 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0306 family. {ECO 0000305}. # SUPFAM SSF50475 SSF50475 # eggNOG COG3787 LUCA # eggNOG ENOG4108ZPB Bacteria BLAST swissprot:YHBP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHBP_ECOLI BioCyc ECOL316407:JW3123-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3123-MONOMER BioCyc EcoCyc:G7648-MONOMER http://biocyc.org/getid?id=EcoCyc:G7648-MONOMER COG COG3787 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3787 DIP DIP-48097N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48097N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2638 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2638 EcoGene EG12785 http://www.ecogene.org/geneInfo.php?eg_id=EG12785 EnsemblBacteria AAC76188 http://www.ensemblgenomes.org/id/AAC76188 EnsemblBacteria AAC76188 http://www.ensemblgenomes.org/id/AAC76188 EnsemblBacteria BAE77200 http://www.ensemblgenomes.org/id/BAE77200 EnsemblBacteria BAE77200 http://www.ensemblgenomes.org/id/BAE77200 EnsemblBacteria BAE77200 http://www.ensemblgenomes.org/id/BAE77200 EnsemblBacteria b3154 http://www.ensemblgenomes.org/id/b3154 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0010181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010181 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 2.30.110.10 http://www.cathdb.info/version/latest/superfamily/2.30.110.10 GeneID 947665 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947665 HAMAP MF_00764 http://hamap.expasy.org/unirule/MF_00764 HOGENOM HOG000103682 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000103682&db=HOGENOM6 IntAct P67762 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P67762* InterPro IPR011194 http://www.ebi.ac.uk/interpro/entry/IPR011194 InterPro IPR012349 http://www.ebi.ac.uk/interpro/entry/IPR012349 KEGG_Gene ecj:JW3123 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3123 KEGG_Gene eco:b3154 http://www.genome.jp/dbget-bin/www_bget?eco:b3154 KEGG_Orthology KO:K09979 http://www.genome.jp/dbget-bin/www_bget?KO:K09979 OMA MTDNTLG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MTDNTLG PSORT swissprot:YHBP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHBP_ECOLI PSORT-B swissprot:YHBP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHBP_ECOLI PSORT2 swissprot:YHBP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHBP_ECOLI Phobius swissprot:YHBP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHBP_ECOLI ProteinModelPortal P67762 http://www.proteinmodelportal.org/query/uniprot/P67762 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417623 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417623 RefSeq WP_000449030 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000449030 SMR P67762 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P67762 STRING 511145.b3154 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3154&targetmode=cogs STRING COG3787 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3787&targetmode=cogs SUPFAM SSF50475 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50475 UniProtKB YHBP_ECOLI http://www.uniprot.org/uniprot/YHBP_ECOLI UniProtKB-AC P67762 http://www.uniprot.org/uniprot/P67762 charge swissprot:YHBP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHBP_ECOLI eggNOG COG3787 http://eggnogapi.embl.de/nog_data/html/tree/COG3787 eggNOG ENOG4108ZPB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZPB epestfind swissprot:YHBP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHBP_ECOLI garnier swissprot:YHBP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHBP_ECOLI helixturnhelix swissprot:YHBP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHBP_ECOLI hmoment swissprot:YHBP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHBP_ECOLI iep swissprot:YHBP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHBP_ECOLI inforesidue swissprot:YHBP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHBP_ECOLI octanol swissprot:YHBP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHBP_ECOLI pepcoil swissprot:YHBP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHBP_ECOLI pepdigest swissprot:YHBP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHBP_ECOLI pepinfo swissprot:YHBP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHBP_ECOLI pepnet swissprot:YHBP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHBP_ECOLI pepstats swissprot:YHBP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHBP_ECOLI pepwheel swissprot:YHBP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHBP_ECOLI pepwindow swissprot:YHBP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHBP_ECOLI sigcleave swissprot:YHBP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHBP_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES pH dependence: Optimum pH is 6.5-7.5. {ECO 0000269|PubMed:4598120}; # BioGrid 4261081 64 # CATALYTIC ACTIVITY PSD_ECOLI Phosphatidyl-L-serine = phosphatidylethanolamine + CO(2). {ECO 0000255|HAMAP- Rule MF_00662, ECO 0000269|PubMed 4598120}. # COFACTOR PSD_ECOLI Name=pyruvate; Xref=ChEBI CHEBI 15361; Evidence={ECO 0000255|HAMAP-Rule MF_00662, ECO 0000269|PubMed 3042771}; Note=Binds 1 pyruvoyl group covalently per subunit. {ECO 0000255|HAMAP-Rule MF_00662, ECO 0000269|PubMed 3042771}; # ENZYME REGULATION Inhibited by ionic detergents such as Barlox- 12, an amine oxide, and sodium dodecyl sulfate. {ECO:0000269|PubMed 4598120}. # EcoGene EG10775 psd # FUNCTION PSD_ECOLI Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Only decarboxylates the lipid-linked form of the serine moiety, and not serine alone or derivatives like phosphoserine or glycerophosphoserine. {ECO 0000255|HAMAP-Rule MF_00662, ECO 0000269|PubMed 4598120}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_function GO:0004609 phosphatidylserine decarboxylase activity; IDA:EcoCyc. # GO_process GO:0006646 phosphatidylethanolamine biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0008654 phospholipid biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # HAMAP MF_00662 PS_decarb_PSD_B_type1 # IntAct P0A8K1 2 # InterPro IPR003817 PS_Dcarbxylase # InterPro IPR033177 PSD # InterPro IPR033178 PSD_type1_pro # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00564 Glycerophospholipid metabolism # Organism PSD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10067 PTHR10067 # PATHWAY PSD_ECOLI Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol step 2/2. {ECO 0000255|HAMAP-Rule MF_00662, ECO 0000269|PubMed 4598120}. # PATRIC 32123893 VBIEscCol129921_4294 # PIR A29234 A29234 # PTM PSD_ECOLI Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N- terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain (PubMed 3042771, PubMed 2406271). During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase (By similarity). {ECO 0000250|UniProtKB B3L2V1, ECO 0000255|HAMAP-Rule MF_00662, ECO 0000269|PubMed 2406271, ECO 0000269|PubMed 3042771}. # Pfam PF02666 PS_Dcarbxylase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Phosphatidylserine decarboxylase alpha chain {ECO:0000255|HAMAP-Rule MF_00662} # RecName Phosphatidylserine decarboxylase alpha chain {ECO:0000255|HAMAP-Rule MF_00662} # RecName Phosphatidylserine decarboxylase beta chain {ECO:0000255|HAMAP-Rule MF_00662} # RecName Phosphatidylserine decarboxylase proenzyme {ECO:0000255|HAMAP-Rule MF_00662} # RefSeq NP_418584 NC_000913.3 # RefSeq WP_000934920 NZ_LN832404.1 # SIMILARITY Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily. {ECO:0000255|HAMAP-Rule MF_00662}. # SUBCELLULAR LOCATION PSD_ECOLI Cell membrane {ECO 0000255|HAMAP- Rule MF_00662, ECO 0000269|PubMed 4598120}; Peripheral membrane protein {ECO 0000255|HAMAP-Rule MF_00662, ECO 0000269|PubMed 4598120}. # SUBUNIT PSD_ECOLI Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit. {ECO 0000255|HAMAP- Rule MF_00662, ECO 0000269|PubMed 3042771}. # TIGRFAMs TIGR00163 PS_decarb # UniPathway UPA00558 UER00616 # eggNOG COG0688 LUCA # eggNOG ENOG4105DJ4 Bacteria BLAST swissprot:PSD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PSD_ECOLI BioCyc ECOL316407:JW4121-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4121-MONOMER BioCyc EcoCyc:PSD-MONOMER http://biocyc.org/getid?id=EcoCyc:PSD-MONOMER BioCyc MetaCyc:PSD-MONOMER http://biocyc.org/getid?id=MetaCyc:PSD-MONOMER COG COG0688 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0688 DOI 10.1016/0076-6879(92)09043-3 http://dx.doi.org/10.1016/0076-6879(92)09043-3 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.1.1.65 {ECO:0000255|HAMAP-Rule:MF_00662} http://www.genome.jp/dbget-bin/www_bget?EC:4.1.1.65 {ECO:0000255|HAMAP-Rule:MF_00662} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J03916 http://www.ebi.ac.uk/ena/data/view/J03916 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 4.1.1.65 {ECO:0000255|HAMAP-Rule:MF_00662} http://enzyme.expasy.org/EC/4.1.1.65 {ECO:0000255|HAMAP-Rule:MF_00662} EchoBASE EB0768 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0768 EcoGene EG10775 http://www.ecogene.org/geneInfo.php?eg_id=EG10775 EnsemblBacteria AAC77120 http://www.ensemblgenomes.org/id/AAC77120 EnsemblBacteria AAC77120 http://www.ensemblgenomes.org/id/AAC77120 EnsemblBacteria BAE78164 http://www.ensemblgenomes.org/id/BAE78164 EnsemblBacteria BAE78164 http://www.ensemblgenomes.org/id/BAE78164 EnsemblBacteria BAE78164 http://www.ensemblgenomes.org/id/BAE78164 EnsemblBacteria b4160 http://www.ensemblgenomes.org/id/b4160 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0004609 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004609 GO_process GO:0006646 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006646 GO_process GO:0008654 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008654 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 948673 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948673 HAMAP MF_00662 http://hamap.expasy.org/unirule/MF_00662 HOGENOM HOG000282407 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000282407&db=HOGENOM6 InParanoid P0A8K1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8K1 IntAct P0A8K1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8K1* IntEnz 4.1.1.65 {ECO:0000255|HAMAP-Rule:MF_00662} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.1.65 {ECO:0000255|HAMAP-Rule:MF_00662} InterPro IPR003817 http://www.ebi.ac.uk/interpro/entry/IPR003817 InterPro IPR033177 http://www.ebi.ac.uk/interpro/entry/IPR033177 InterPro IPR033178 http://www.ebi.ac.uk/interpro/entry/IPR033178 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4121 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4121 KEGG_Gene eco:b4160 http://www.genome.jp/dbget-bin/www_bget?eco:b4160 KEGG_Orthology KO:K01613 http://www.genome.jp/dbget-bin/www_bget?KO:K01613 KEGG_Pathway ko00564 http://www.genome.jp/kegg-bin/show_pathway?ko00564 KEGG_Reaction rn:R02055 http://www.genome.jp/dbget-bin/www_bget?rn:R02055 OMA GSMATVW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GSMATVW PANTHER PTHR10067 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10067 PSORT swissprot:PSD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PSD_ECOLI PSORT-B swissprot:PSD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PSD_ECOLI PSORT2 swissprot:PSD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PSD_ECOLI Pfam PF02666 http://pfam.xfam.org/family/PF02666 Phobius swissprot:PSD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PSD_ECOLI PhylomeDB P0A8K1 http://phylomedb.org/?seqid=P0A8K1 ProteinModelPortal P0A8K1 http://www.proteinmodelportal.org/query/uniprot/P0A8K1 PubMed 1495415 http://www.ncbi.nlm.nih.gov/pubmed/1495415 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2406271 http://www.ncbi.nlm.nih.gov/pubmed/2406271 PubMed 3042771 http://www.ncbi.nlm.nih.gov/pubmed/3042771 PubMed 338609 http://www.ncbi.nlm.nih.gov/pubmed/338609 PubMed 4598120 http://www.ncbi.nlm.nih.gov/pubmed/4598120 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418584 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418584 RefSeq WP_000934920 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000934920 STRING 511145.b4160 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4160&targetmode=cogs STRING COG0688 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0688&targetmode=cogs TIGRFAMs TIGR00163 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00163 UniProtKB PSD_ECOLI http://www.uniprot.org/uniprot/PSD_ECOLI UniProtKB-AC P0A8K1 http://www.uniprot.org/uniprot/P0A8K1 charge swissprot:PSD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PSD_ECOLI eggNOG COG0688 http://eggnogapi.embl.de/nog_data/html/tree/COG0688 eggNOG ENOG4105DJ4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DJ4 epestfind swissprot:PSD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PSD_ECOLI garnier swissprot:PSD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PSD_ECOLI helixturnhelix swissprot:PSD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PSD_ECOLI hmoment swissprot:PSD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PSD_ECOLI iep swissprot:PSD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PSD_ECOLI inforesidue swissprot:PSD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PSD_ECOLI octanol swissprot:PSD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PSD_ECOLI pepcoil swissprot:PSD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PSD_ECOLI pepdigest swissprot:PSD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PSD_ECOLI pepinfo swissprot:PSD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PSD_ECOLI pepnet swissprot:PSD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PSD_ECOLI pepstats swissprot:PSD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PSD_ECOLI pepwheel swissprot:PSD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PSD_ECOLI pepwindow swissprot:PSD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PSD_ECOLI sigcleave swissprot:PSD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PSD_ECOLI ## Database ID URL or Descriptions # AltName OXYR_ECOLI Morphology and auto-aggregation control protein # BioGrid 4263457 5 # DrugBank DB03793 Benzoic Acid # ENZYME REGULATION OXYR_ECOLI Activated by oxidation of Cys-199 resulting in the alternative formation of cystine, sulfenic acid, S-nitroso- or glutathione-bound cysteine. # EcoGene EG10681 oxyR # FUNCTION OXYR_ECOLI Hydrogen peroxide sensor. Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS (a regulatory RNA), dps, fur and grxA. OxyR expression is negatively autoregulated by binding to a 43 bp region upstream of its own coding sequence. OxyR is inactivated by reduction of its essential disulfide bond by the product of GrxA, itself positively regulated by OxyR. Has also a positive regulatory effect on the production of surface proteins that control the colony morphology and auto-aggregation ability. {ECO 0000269|PubMed 9497290}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000986 bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding; IDA:EcoCyc. # GO_function GO:0001131 transcription factor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0006979 response to oxidative stress; IDA:EcoCyc. # GO_process GO:0051409 response to nitrosative stress; IDA:EcoCyc. # GO_process GO:2000142 regulation of DNA-templated transcription, initiation; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # IntAct P0ACQ4 2 # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR005119 LysR_subst-bd # InterPro IPR011991 WHTH_DNA-bd_dom # KEGG_Brite ko03000 Transcription factors # MISCELLANEOUS OXYR_ECOLI Oxidized OxyR can be reduced and inactivated by glutaredoxin 1, the product of grxA, whose expression is regulated by OxyR itself. # Organism OXYR_ECOLI Escherichia coli (strain K12) # PATRIC 32123443 VBIEscCol129921_4082 # PDB 1I69 X-ray; 2.70 A; A/B=87-305 # PDB 1I6A X-ray; 2.30 A; A=87-305 # PIR D65203 RGECOX # PRINTS PR00039 HTHLYSR # PROSITE PS50931 HTH_LYSR # PTM OXYR_ECOLI Glutathionylation in response to redox signaling triggers the onset of transcriptional activity with a specific DNA-binding affinity. {ECO 0000269|PubMed 12015987}. # PTM OXYR_ECOLI Oxidized on Cys-199; the Cys-SOH formed in response to oxidative signaling triggers a conformational change and the onset of transcriptional activity with a specific DNA-binding affinity. Cys-199-SOH rapidly reacts with Cys-208-SH to form a disulfide bond. {ECO 0000269|PubMed 12015987}. # PTM OXYR_ECOLI S-nitrosylation in response to nitrosative signaling triggers a conformational change and the onset of transcriptional activity with a specific DNA-binding affinity. {ECO 0000269|PubMed 12015987}. # Pfam PF00126 HTH_1 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName OXYR_ECOLI Hydrogen peroxide-inducible genes activator # RefSeq NP_418396 NC_000913.3 # RefSeq WP_001025939 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lysR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00253}. # SUBUNIT OXYR_ECOLI Homodimer and homotetramer. # SUPFAM SSF46785 SSF46785 # eggNOG ENOG4105C5Q Bacteria # eggNOG ENOG410XNR2 LUCA BLAST swissprot:OXYR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:OXYR_ECOLI BioCyc ECOL316407:JW3933-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3933-MONOMER BioCyc EcoCyc:PD00214 http://biocyc.org/getid?id=EcoCyc:PD00214 COG COG0583 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0583 DIP DIP-10419N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10419N DOI 10.1007/BF00332397 http://dx.doi.org/10.1007/BF00332397 DOI 10.1016/S0092-8674(02)00723-7 http://dx.doi.org/10.1016/S0092-8674(02)00723-7 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.86.10.3484 http://dx.doi.org/10.1073/pnas.86.10.3484 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1099/00221287-136-3-455 http://dx.doi.org/10.1099/00221287-136-3-455 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1126/science.279.5357.1718 http://dx.doi.org/10.1126/science.279.5357.1718 DrugBank DB03793 http://www.drugbank.ca/drugs/DB03793 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J04553 http://www.ebi.ac.uk/ena/data/view/J04553 EMBL M34102 http://www.ebi.ac.uk/ena/data/view/M34102 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X16531 http://www.ebi.ac.uk/ena/data/view/X16531 EMBL X52666 http://www.ebi.ac.uk/ena/data/view/X52666 EchoBASE EB0675 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0675 EcoGene EG10681 http://www.ecogene.org/geneInfo.php?eg_id=EG10681 EnsemblBacteria AAC76943 http://www.ensemblgenomes.org/id/AAC76943 EnsemblBacteria AAC76943 http://www.ensemblgenomes.org/id/AAC76943 EnsemblBacteria BAE77350 http://www.ensemblgenomes.org/id/BAE77350 EnsemblBacteria BAE77350 http://www.ensemblgenomes.org/id/BAE77350 EnsemblBacteria BAE77350 http://www.ensemblgenomes.org/id/BAE77350 EnsemblBacteria b3961 http://www.ensemblgenomes.org/id/b3961 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000986 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000986 GO_function GO:0001131 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001131 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0006979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979 GO_process GO:0051409 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051409 GO_process GO:2000142 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000142 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 948462 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948462 HOGENOM HOG000233514 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000233514&db=HOGENOM6 InParanoid P0ACQ4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACQ4 IntAct P0ACQ4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACQ4* InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW3933 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3933 KEGG_Gene eco:b3961 http://www.genome.jp/dbget-bin/www_bget?eco:b3961 KEGG_Orthology KO:K04761 http://www.genome.jp/dbget-bin/www_bget?KO:K04761 OMA CPEFARF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CPEFARF PDB 1I69 http://www.ebi.ac.uk/pdbe-srv/view/entry/1I69 PDB 1I6A http://www.ebi.ac.uk/pdbe-srv/view/entry/1I6A PDBsum 1I69 http://www.ebi.ac.uk/pdbsum/1I69 PDBsum 1I6A http://www.ebi.ac.uk/pdbsum/1I6A PRINTS PR00039 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00039 PROSITE PS50931 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50931 PSORT swissprot:OXYR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:OXYR_ECOLI PSORT-B swissprot:OXYR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:OXYR_ECOLI PSORT2 swissprot:OXYR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:OXYR_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:OXYR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:OXYR_ECOLI PhylomeDB P0ACQ4 http://phylomedb.org/?seqid=P0ACQ4 ProteinModelPortal P0ACQ4 http://www.proteinmodelportal.org/query/uniprot/P0ACQ4 PubMed 12015987 http://www.ncbi.nlm.nih.gov/pubmed/12015987 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1864839 http://www.ncbi.nlm.nih.gov/pubmed/1864839 PubMed 2167922 http://www.ncbi.nlm.nih.gov/pubmed/2167922 PubMed 2471187 http://www.ncbi.nlm.nih.gov/pubmed/2471187 PubMed 2511419 http://www.ncbi.nlm.nih.gov/pubmed/2511419 PubMed 2551682 http://www.ncbi.nlm.nih.gov/pubmed/2551682 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9497290 http://www.ncbi.nlm.nih.gov/pubmed/9497290 RefSeq NP_418396 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418396 RefSeq WP_001025939 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001025939 SMR P0ACQ4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACQ4 STRING 511145.b3961 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3961&targetmode=cogs STRING COG0583 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0583&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB OXYR_ECOLI http://www.uniprot.org/uniprot/OXYR_ECOLI UniProtKB-AC P0ACQ4 http://www.uniprot.org/uniprot/P0ACQ4 charge swissprot:OXYR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:OXYR_ECOLI eggNOG ENOG4105C5Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C5Q eggNOG ENOG410XNR2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNR2 epestfind swissprot:OXYR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:OXYR_ECOLI garnier swissprot:OXYR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:OXYR_ECOLI helixturnhelix swissprot:OXYR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:OXYR_ECOLI hmoment swissprot:OXYR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:OXYR_ECOLI iep swissprot:OXYR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:OXYR_ECOLI inforesidue swissprot:OXYR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:OXYR_ECOLI octanol swissprot:OXYR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:OXYR_ECOLI pepcoil swissprot:OXYR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:OXYR_ECOLI pepdigest swissprot:OXYR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:OXYR_ECOLI pepinfo swissprot:OXYR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:OXYR_ECOLI pepnet swissprot:OXYR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:OXYR_ECOLI pepstats swissprot:OXYR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:OXYR_ECOLI pepwheel swissprot:OXYR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:OXYR_ECOLI pepwindow swissprot:OXYR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:OXYR_ECOLI sigcleave swissprot:OXYR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:OXYR_ECOLI ## Database ID URL or Descriptions # AltName ATP:glycerol 3-phosphotransferase {ECO 0000255|HAMAP-Rule:MF_00186} # AltName Glycerokinase {ECO:0000255|HAMAP-Rule MF_00186} # BIOPHYSICOCHEMICAL PROPERTIES GLPK_ECOLI Kinetic parameters KM=1.3 uM for glycerol {ECO 0000269|PubMed 2985549, ECO 0000269|PubMed 4575199, ECO 0000269|PubMed 5335908, ECO 0000269|PubMed 9817843}; KM=400 uM for D-glyceraldehyde {ECO 0000269|PubMed 2985549, ECO 0000269|PubMed 4575199, ECO 0000269|PubMed 5335908, ECO 0000269|PubMed 9817843}; KM=500 uM for dihydroxyacetone {ECO 0000269|PubMed 2985549, ECO 0000269|PubMed 4575199, ECO 0000269|PubMed 5335908, ECO 0000269|PubMed 9817843}; KM=3 mM for L-glyceraldehyde {ECO 0000269|PubMed 2985549, ECO 0000269|PubMed 4575199, ECO 0000269|PubMed 5335908, ECO 0000269|PubMed 9817843}; KM=4 mM for ATP {ECO 0000269|PubMed 2985549, ECO 0000269|PubMed 4575199, ECO 0000269|PubMed 5335908, ECO 0000269|PubMed 9817843}; pH dependence Optimum pH is 9.8. {ECO 0000269|PubMed 2985549, ECO 0000269|PubMed 4575199, ECO 0000269|PubMed 5335908, ECO 0000269|PubMed 9817843}; # BRENDA 2.7.1.30 2026 # BioGrid 4263162 380 # CATALYTIC ACTIVITY GLPK_ECOLI ATP + glycerol = ADP + sn-glycerol 3- phosphate. {ECO 0000255|HAMAP-Rule MF_00186, ECO 0000269|PubMed 5335908}. # ENZYME REGULATION GLPK_ECOLI Activity of this regulatory enzyme is affected by several metabolites. The non-competitive allosteric inhibition by fructose 1,6-bisphosphate (FBP) causes alterations in the quaternary structure of the enzyme. FBP inhibition requires that the enzyme exist only in a tetrameric state. Salt such as KCl reduces the affinity of the tetrameric form of the enzyme for FBP. Unphosphorylated phosphocarrier protein EIIA-Glc (III-Glc), an integral component of the bacterial phosphotransferase (PTS) system, also inhibits non-competitively and allostericaly the activity. Unlike FBP, both the dimer and the tetramer appear to be fully sensitive to enzyme EIIA-Glc inhibition. Zn(+2) greatly enhances the inhibitory potency of EIIA-Glc. Both allosteric regulatory agents is strongly pH dependent, with maximal inhibition occurring at pH 6.5. {ECO 0000269|PubMed 215195, ECO 0000269|PubMed 2985549, ECO 0000269|PubMed 31903, ECO 0000269|PubMed 4575199, ECO 0000269|PubMed 5328677, ECO 0000269|PubMed 8430315, ECO 0000269|PubMed 9817843, ECO 0000269|PubMed 9843423}. # EcoGene EG10398 glpK # FUNCTION GLPK_ECOLI Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. It also catalyzes the phosphorylation of dihydroxyacetone, L-glyceraldehyde and D-glyceraldehyde. It uses only ATP. {ECO 0000255|HAMAP-Rule MF_00186, ECO 0000269|PubMed 2826434, ECO 0000269|PubMed 4575199, ECO 0000269|PubMed 5335908}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0004370 glycerol kinase activity; IDA:UniProtKB. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008270 zinc ion binding; IDA:UniProtKB. # GO_function GO:0046872 metal ion binding; IDA:EcoCyc. # GO_process GO:0006071 glycerol metabolic process; IDA:UniProtKB. # GO_process GO:0006072 glycerol-3-phosphate metabolic process; IEA:UniProtKB-HAMAP. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0016310 phosphorylation; IDA:EcoCyc. # GO_process GO:0019563 glycerol catabolic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # HAMAP MF_00186 Glycerol_kin # INDUCTION By L-alpha-glycerol 3-phosphate. {ECO:0000269|PubMed 2826434}. # IntAct P0A6F3 15 # InterPro IPR000577 Carb_kinase_FGGY # InterPro IPR005999 Glycerol_kin # InterPro IPR018483 Carb_kinase_FGGY_CS # InterPro IPR018484 Carb_kinase_FGGY_N # InterPro IPR018485 Carb_kinase_FGGY_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00561 Glycerolipid metabolism # KEGG_Pathway ko03320 PPAR signaling pathway # KEGG_Pathway ko04626 Plant-pathogen interaction # Organism GLPK_ECOLI Escherichia coli (strain K12) # PATHWAY Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. {ECO 0000255|HAMAP-Rule:MF_00186}. # PATRIC 32123365 VBIEscCol129921_4043 # PDB 1BO5 X-ray; 3.20 A; O/Z=2-502 # PDB 1BOT X-ray; 3.05 A; O/Z=2-502 # PDB 1BU6 X-ray; 2.37 A; O/X/Y/Z=2-502 # PDB 1BWF X-ray; 3.00 A; O/Y=2-502 # PDB 1GLA X-ray; 2.60 A; G=2-502 # PDB 1GLB X-ray; 2.60 A; G=2-502 # PDB 1GLC X-ray; 2.65 A; G=2-502 # PDB 1GLD X-ray; 2.93 A; G=2-502 # PDB 1GLE X-ray; 2.94 A; G=2-502 # PDB 1GLF X-ray; 2.62 A; O/X/Y/Z=2-502 # PDB 1GLJ X-ray; 3.00 A; O/Y=2-502 # PDB 1GLL X-ray; 3.00 A; O/Y=2-502 # PDB 3EZW X-ray; 2.00 A; A/B/C/D/E/F/G/H=2-501 # PIR A27339 KIECGL # PIRSF PIRSF000538 GlpK # PROSITE PS00445 FGGY_KINASES_2 # PROSITE PS00933 FGGY_KINASES_1 # Pfam PF00370 FGGY_N # Pfam PF02782 FGGY_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Glycerol kinase {ECO:0000255|HAMAP-Rule MF_00186} # RefSeq NP_418361 NC_000913.3 # RefSeq WP_000136788 NZ_LN832404.1 # SIMILARITY Belongs to the FGGY kinase family. {ECO:0000255|HAMAP- Rule MF_00186}. # SUBUNIT GLPK_ECOLI Homotetramer and homodimer (in equilibrium). Heterodimer with EIIA-Glc (crr). Binds 1 zinc ion per glycerol kinase EIIA-Glc dimer. The zinc ion is important for dimerization. {ECO 0000255|HAMAP-Rule MF_00186, ECO 0000269|PubMed 10090737, ECO 0000269|PubMed 17441732, ECO 0000269|PubMed 215194, ECO 0000269|PubMed 215195, ECO 0000269|PubMed 4934840, ECO 0000269|PubMed 8170944, ECO 0000269|PubMed 8430315, ECO 0000269|PubMed 9817843, ECO 0000269|PubMed 9843423}. # TIGRFAMs TIGR01311 glycerol_kin # UniPathway UPA00618 UER00672 # WEB RESOURCE GLPK_ECOLI Name=Worthington enzyme manual; URL="http //www.worthington-biochem.com/GKEC/"; # eggNOG COG0554 LUCA # eggNOG ENOG4107QVN Bacteria BLAST swissprot:GLPK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLPK_ECOLI BioCyc ECOL316407:JW3897-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3897-MONOMER BioCyc EcoCyc:GLYCEROL-KIN-MONOMER http://biocyc.org/getid?id=EcoCyc:GLYCEROL-KIN-MONOMER BioCyc MetaCyc:GLYCEROL-KIN-MONOMER http://biocyc.org/getid?id=MetaCyc:GLYCEROL-KIN-MONOMER COG COG0554 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0554 DIP DIP-36011N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36011N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/S0969-2126(98)00140-3 http://dx.doi.org/10.1016/S0969-2126(98)00140-3 DOI 10.1021/bi00617a010 http://dx.doi.org/10.1021/bi00617a010 DOI 10.1021/bi00617a011 http://dx.doi.org/10.1021/bi00617a011 DOI 10.1021/bi00617a012 http://dx.doi.org/10.1021/bi00617a012 DOI 10.1021/bi700096p http://dx.doi.org/10.1021/bi700096p DOI 10.1021/bi981616s http://dx.doi.org/10.1021/bi981616s DOI 10.1021/bi982460z http://dx.doi.org/10.1021/bi982460z DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.91.9.3544 http://dx.doi.org/10.1073/pnas.91.9.3544 DOI 10.1074/mcp.M111.012658 http://dx.doi.org/10.1074/mcp.M111.012658 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1111/j.1365-2958.1996.tb02652.x http://dx.doi.org/10.1111/j.1365-2958.1996.tb02652.x DOI 10.1126/science.153.3737.755 http://dx.doi.org/10.1126/science.153.3737.755 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1126/science.8430315 http://dx.doi.org/10.1126/science.8430315 EC_number EC:2.7.1.30 {ECO:0000255|HAMAP-Rule:MF_00186} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.30 {ECO:0000255|HAMAP-Rule:MF_00186} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL M18393 http://www.ebi.ac.uk/ena/data/view/M18393 EMBL M55990 http://www.ebi.ac.uk/ena/data/view/M55990 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U41468 http://www.ebi.ac.uk/ena/data/view/U41468 EMBL X15054 http://www.ebi.ac.uk/ena/data/view/X15054 ENZYME 2.7.1.30 {ECO:0000255|HAMAP-Rule:MF_00186} http://enzyme.expasy.org/EC/2.7.1.30 {ECO:0000255|HAMAP-Rule:MF_00186} EchoBASE EB0393 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0393 EcoGene EG10398 http://www.ecogene.org/geneInfo.php?eg_id=EG10398 EnsemblBacteria AAC76908 http://www.ensemblgenomes.org/id/AAC76908 EnsemblBacteria AAC76908 http://www.ensemblgenomes.org/id/AAC76908 EnsemblBacteria BAE77384 http://www.ensemblgenomes.org/id/BAE77384 EnsemblBacteria BAE77384 http://www.ensemblgenomes.org/id/BAE77384 EnsemblBacteria BAE77384 http://www.ensemblgenomes.org/id/BAE77384 EnsemblBacteria b3926 http://www.ensemblgenomes.org/id/b3926 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004370 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004370 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006071 GO_process GO:0006072 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006072 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0016310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016310 GO_process GO:0019563 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019563 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 948423 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948423 HAMAP MF_00186 http://hamap.expasy.org/unirule/MF_00186 HOGENOM HOG000222134 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000222134&db=HOGENOM6 InParanoid P0A6F3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6F3 IntAct P0A6F3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6F3* IntEnz 2.7.1.30 {ECO:0000255|HAMAP-Rule:MF_00186} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.30 {ECO:0000255|HAMAP-Rule:MF_00186} InterPro IPR000577 http://www.ebi.ac.uk/interpro/entry/IPR000577 InterPro IPR005999 http://www.ebi.ac.uk/interpro/entry/IPR005999 InterPro IPR018483 http://www.ebi.ac.uk/interpro/entry/IPR018483 InterPro IPR018484 http://www.ebi.ac.uk/interpro/entry/IPR018484 InterPro IPR018485 http://www.ebi.ac.uk/interpro/entry/IPR018485 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3897 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3897 KEGG_Gene eco:b3926 http://www.genome.jp/dbget-bin/www_bget?eco:b3926 KEGG_Orthology KO:K00864 http://www.genome.jp/dbget-bin/www_bget?KO:K00864 KEGG_Pathway ko00561 http://www.genome.jp/kegg-bin/show_pathway?ko00561 KEGG_Pathway ko03320 http://www.genome.jp/kegg-bin/show_pathway?ko03320 KEGG_Pathway ko04626 http://www.genome.jp/kegg-bin/show_pathway?ko04626 KEGG_Reaction rn:R00847 http://www.genome.jp/dbget-bin/www_bget?rn:R00847 OMA PMEIFAT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PMEIFAT PDB 1BO5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1BO5 PDB 1BOT http://www.ebi.ac.uk/pdbe-srv/view/entry/1BOT PDB 1BU6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1BU6 PDB 1BWF http://www.ebi.ac.uk/pdbe-srv/view/entry/1BWF PDB 1GLA http://www.ebi.ac.uk/pdbe-srv/view/entry/1GLA PDB 1GLB http://www.ebi.ac.uk/pdbe-srv/view/entry/1GLB PDB 1GLC http://www.ebi.ac.uk/pdbe-srv/view/entry/1GLC PDB 1GLD http://www.ebi.ac.uk/pdbe-srv/view/entry/1GLD PDB 1GLE http://www.ebi.ac.uk/pdbe-srv/view/entry/1GLE PDB 1GLF http://www.ebi.ac.uk/pdbe-srv/view/entry/1GLF PDB 1GLJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1GLJ PDB 1GLL http://www.ebi.ac.uk/pdbe-srv/view/entry/1GLL PDB 3EZW http://www.ebi.ac.uk/pdbe-srv/view/entry/3EZW PDBsum 1BO5 http://www.ebi.ac.uk/pdbsum/1BO5 PDBsum 1BOT http://www.ebi.ac.uk/pdbsum/1BOT PDBsum 1BU6 http://www.ebi.ac.uk/pdbsum/1BU6 PDBsum 1BWF http://www.ebi.ac.uk/pdbsum/1BWF PDBsum 1GLA http://www.ebi.ac.uk/pdbsum/1GLA PDBsum 1GLB http://www.ebi.ac.uk/pdbsum/1GLB PDBsum 1GLC http://www.ebi.ac.uk/pdbsum/1GLC PDBsum 1GLD http://www.ebi.ac.uk/pdbsum/1GLD PDBsum 1GLE http://www.ebi.ac.uk/pdbsum/1GLE PDBsum 1GLF http://www.ebi.ac.uk/pdbsum/1GLF PDBsum 1GLJ http://www.ebi.ac.uk/pdbsum/1GLJ PDBsum 1GLL http://www.ebi.ac.uk/pdbsum/1GLL PDBsum 3EZW http://www.ebi.ac.uk/pdbsum/3EZW PROSITE PS00445 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00445 PROSITE PS00933 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00933 PSORT swissprot:GLPK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLPK_ECOLI PSORT-B swissprot:GLPK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLPK_ECOLI PSORT2 swissprot:GLPK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLPK_ECOLI Pfam PF00370 http://pfam.xfam.org/family/PF00370 Pfam PF02782 http://pfam.xfam.org/family/PF02782 Phobius swissprot:GLPK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLPK_ECOLI PhylomeDB P0A6F3 http://phylomedb.org/?seqid=P0A6F3 ProteinModelPortal P0A6F3 http://www.proteinmodelportal.org/query/uniprot/P0A6F3 PubMed 10090737 http://www.ncbi.nlm.nih.gov/pubmed/10090737 PubMed 1372899 http://www.ncbi.nlm.nih.gov/pubmed/1372899 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17441732 http://www.ncbi.nlm.nih.gov/pubmed/17441732 PubMed 215194 http://www.ncbi.nlm.nih.gov/pubmed/215194 PubMed 215195 http://www.ncbi.nlm.nih.gov/pubmed/215195 PubMed 21908771 http://www.ncbi.nlm.nih.gov/pubmed/21908771 PubMed 2544860 http://www.ncbi.nlm.nih.gov/pubmed/2544860 PubMed 2826434 http://www.ncbi.nlm.nih.gov/pubmed/2826434 PubMed 2985549 http://www.ncbi.nlm.nih.gov/pubmed/2985549 PubMed 31903 http://www.ncbi.nlm.nih.gov/pubmed/31903 PubMed 4575199 http://www.ncbi.nlm.nih.gov/pubmed/4575199 PubMed 4934840 http://www.ncbi.nlm.nih.gov/pubmed/4934840 PubMed 5328677 http://www.ncbi.nlm.nih.gov/pubmed/5328677 PubMed 5335908 http://www.ncbi.nlm.nih.gov/pubmed/5335908 PubMed 8170944 http://www.ncbi.nlm.nih.gov/pubmed/8170944 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 8430315 http://www.ncbi.nlm.nih.gov/pubmed/8430315 PubMed 8631672 http://www.ncbi.nlm.nih.gov/pubmed/8631672 PubMed 8899705 http://www.ncbi.nlm.nih.gov/pubmed/8899705 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9817843 http://www.ncbi.nlm.nih.gov/pubmed/9817843 PubMed 9843423 http://www.ncbi.nlm.nih.gov/pubmed/9843423 RefSeq NP_418361 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418361 RefSeq WP_000136788 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000136788 SMR P0A6F3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6F3 STRING 511145.b3926 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3926&targetmode=cogs STRING COG0554 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0554&targetmode=cogs SWISS-2DPAGE P0A6F3 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A6F3 TIGRFAMs TIGR01311 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01311 UniProtKB GLPK_ECOLI http://www.uniprot.org/uniprot/GLPK_ECOLI UniProtKB-AC P0A6F3 http://www.uniprot.org/uniprot/P0A6F3 charge swissprot:GLPK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLPK_ECOLI eggNOG COG0554 http://eggnogapi.embl.de/nog_data/html/tree/COG0554 eggNOG ENOG4107QVN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QVN epestfind swissprot:GLPK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLPK_ECOLI garnier swissprot:GLPK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLPK_ECOLI helixturnhelix swissprot:GLPK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLPK_ECOLI hmoment swissprot:GLPK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLPK_ECOLI iep swissprot:GLPK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLPK_ECOLI inforesidue swissprot:GLPK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLPK_ECOLI octanol swissprot:GLPK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLPK_ECOLI pepcoil swissprot:GLPK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLPK_ECOLI pepdigest swissprot:GLPK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLPK_ECOLI pepinfo swissprot:GLPK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLPK_ECOLI pepnet swissprot:GLPK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLPK_ECOLI pepstats swissprot:GLPK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLPK_ECOLI pepwheel swissprot:GLPK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLPK_ECOLI pepwindow swissprot:GLPK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLPK_ECOLI sigcleave swissprot:GLPK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLPK_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES COF_ECOLI Kinetic parameters KM=0.68 mM for PLP (with magnesium ions as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; KM=2.5 mM for 2-deoxyglucose-6-P (with magnesium ions as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; pH dependence Optimum pH is between 6 and 7.5. {ECO 0000269|PubMed 16990279}; # BioGrid 4260651 7 # COFACTOR COF_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_01847, ECO 0000269|PubMed 16990279}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000255|HAMAP-Rule MF_01847, ECO 0000269|PubMed 16990279}; Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000255|HAMAP-Rule MF_01847, ECO 0000269|PubMed 16990279}; Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000255|HAMAP-Rule MF_01847, ECO 0000269|PubMed 16990279}; Note=Magnesium. Can also use other divalent metal cations as manganese, cobalt or zinc. {ECO 0000255|HAMAP-Rule MF_01847, ECO 0000269|PubMed 16990279}; # EcoGene EG13216 cof # FUNCTION COF_ECOLI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P). Can also hydrolyze other substrates such as MeO-HMP-PP and 4-amino-2- trifluoromethyl 5-hydroxymethylpyrimidine pyrophosphate (CF3-HMP- PP) to give MeO-HMP-P and 4-amino-2-trifluoromethyl-5- hydroxymethylpyrimidine phosphate. This hydrolysis generates resistance to the antibiotics (bacimethrin, CF3-HMP) by reducing the formation of their toxic forms, 2'-methoxythiamin pyrophosphate (MeO-TPP) and CF3-HMP-PP. Also hydrolyzes pyridoxal- phosphate (PLP) and flavin mononucleotide (FMN), and purines (GMP and IMP) as secondary substrates. {ECO 0000255|HAMAP- Rule MF_01847, ECO 0000269|PubMed 15292217, ECO 0000269|PubMed 16990279}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0000287 magnesium ion binding; IDA:UniProtKB. # GO_function GO:0016791 phosphatase activity; IDA:UniProtKB. # GO_function GO:0017110 nucleoside-diphosphatase activity; IDA:EcoliWiki. # GO_process GO:0009228 thiamine biosynthetic process; IMP:EcoliWiki. # GO_process GO:0017001 antibiotic catabolic process; IDA:UniProtKB. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.1000 -; 2. # HAMAP MF_01847 HMP_PP_phosphat # InterPro IPR000150 Hypothet_cof # InterPro IPR006379 HAD-SF_hydro_IIB # InterPro IPR023214 HAD-like_dom # InterPro IPR023938 HMP-PP_phosphatase # KEGG_Brite ko01000 Enzymes # Organism COF_ECOLI Escherichia coli (strain K12) # PATRIC 32116045 VBIEscCol129921_0464 # PIR F64774 F64774 # PROSITE PS01228 COF_1 # PROSITE PS01229 COF_2 # Pfam PF08282 Hydrolase_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HMP-PP phosphatase {ECO:0000255|HAMAP-Rule MF_01847} # RefSeq NP_414980 NC_000913.3 # RefSeq WP_001336137 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40202.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA91181.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the HAD-like hydrolase superfamily. Cof family. {ECO:0000255|HAMAP-Rule MF_01847}. # SUPFAM SSF56784 SSF56784 # TIGRFAMs TIGR00099 Cof-subfamily # TIGRFAMs TIGR01484 HAD-SF-IIB # eggNOG COG0561 LUCA # eggNOG ENOG4108AZI Bacteria BLAST swissprot:COF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:COF_ECOLI BioCyc ECOL316407:JW0436-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0436-MONOMER BioCyc EcoCyc:G6246-MONOMER http://biocyc.org/getid?id=EcoCyc:G6246-MONOMER BioCyc MetaCyc:G6246-MONOMER http://biocyc.org/getid?id=MetaCyc:G6246-MONOMER COG COG0561 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0561 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M404284200 http://dx.doi.org/10.1074/jbc.M404284200 DOI 10.1074/jbc.M605449200 http://dx.doi.org/10.1074/jbc.M605449200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.1.- {ECO:0000255|HAMAP-Rule:MF_01847} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.1.- {ECO:0000255|HAMAP-Rule:MF_01847} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D82943 http://www.ebi.ac.uk/ena/data/view/D82943 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL Z54355 http://www.ebi.ac.uk/ena/data/view/Z54355 ENZYME 3.6.1.- {ECO:0000255|HAMAP-Rule:MF_01847} http://enzyme.expasy.org/EC/3.6.1.- {ECO:0000255|HAMAP-Rule:MF_01847} EchoBASE EB3007 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3007 EcoGene EG13216 http://www.ecogene.org/geneInfo.php?eg_id=EG13216 EnsemblBacteria AAC73549 http://www.ensemblgenomes.org/id/AAC73549 EnsemblBacteria AAC73549 http://www.ensemblgenomes.org/id/AAC73549 EnsemblBacteria BAE76226 http://www.ensemblgenomes.org/id/BAE76226 EnsemblBacteria BAE76226 http://www.ensemblgenomes.org/id/BAE76226 EnsemblBacteria BAE76226 http://www.ensemblgenomes.org/id/BAE76226 EnsemblBacteria b0446 http://www.ensemblgenomes.org/id/b0446 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GO_function GO:0017110 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017110 GO_process GO:0009228 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009228 GO_process GO:0017001 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017001 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.1000 http://www.cathdb.info/version/latest/superfamily/3.40.50.1000 GeneID 945089 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945089 HAMAP MF_01847 http://hamap.expasy.org/unirule/MF_01847 HOGENOM HOG000184784 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000184784&db=HOGENOM6 InParanoid P46891 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P46891 IntAct P46891 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P46891* IntEnz 3.6.1.- {ECO:0000255|HAMAP-Rule:MF_01847} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.1.- {ECO:0000255|HAMAP-Rule:MF_01847} InterPro IPR000150 http://www.ebi.ac.uk/interpro/entry/IPR000150 InterPro IPR006379 http://www.ebi.ac.uk/interpro/entry/IPR006379 InterPro IPR023214 http://www.ebi.ac.uk/interpro/entry/IPR023214 InterPro IPR023938 http://www.ebi.ac.uk/interpro/entry/IPR023938 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0436 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0436 KEGG_Gene eco:b0446 http://www.genome.jp/dbget-bin/www_bget?eco:b0446 KEGG_Orthology KO:K11938 http://www.genome.jp/dbget-bin/www_bget?KO:K11938 OMA SHIISAN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SHIISAN PROSITE PS01228 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01228 PROSITE PS01229 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01229 PSORT swissprot:COF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:COF_ECOLI PSORT-B swissprot:COF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:COF_ECOLI PSORT2 swissprot:COF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:COF_ECOLI Pfam PF08282 http://pfam.xfam.org/family/PF08282 Phobius swissprot:COF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:COF_ECOLI PhylomeDB P46891 http://phylomedb.org/?seqid=P46891 ProteinModelPortal P46891 http://www.proteinmodelportal.org/query/uniprot/P46891 PubMed 15292217 http://www.ncbi.nlm.nih.gov/pubmed/15292217 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16990279 http://www.ncbi.nlm.nih.gov/pubmed/16990279 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414980 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414980 RefSeq WP_001336137 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001336137 SMR P46891 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P46891 STRING 511145.b0446 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0446&targetmode=cogs STRING COG0561 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0561&targetmode=cogs SUPFAM SSF56784 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784 TIGRFAMs TIGR00099 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00099 TIGRFAMs TIGR01484 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01484 UniProtKB COF_ECOLI http://www.uniprot.org/uniprot/COF_ECOLI UniProtKB-AC P46891 http://www.uniprot.org/uniprot/P46891 charge swissprot:COF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:COF_ECOLI eggNOG COG0561 http://eggnogapi.embl.de/nog_data/html/tree/COG0561 eggNOG ENOG4108AZI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108AZI epestfind swissprot:COF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:COF_ECOLI garnier swissprot:COF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:COF_ECOLI helixturnhelix swissprot:COF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:COF_ECOLI hmoment swissprot:COF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:COF_ECOLI iep swissprot:COF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:COF_ECOLI inforesidue swissprot:COF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:COF_ECOLI octanol swissprot:COF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:COF_ECOLI pepcoil swissprot:COF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:COF_ECOLI pepdigest swissprot:COF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:COF_ECOLI pepinfo swissprot:COF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:COF_ECOLI pepnet swissprot:COF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:COF_ECOLI pepstats swissprot:COF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:COF_ECOLI pepwheel swissprot:COF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:COF_ECOLI pepwindow swissprot:COF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:COF_ECOLI sigcleave swissprot:COF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:COF_ECOLI ## Database ID URL or Descriptions # BioGrid 4260227 9 # EcoGene EG13807 lsrC # FUNCTION LSRC_ECOLI Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane (Probable). {ECO 0000305|PubMed 15601708}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IBA:GO_Central. # GO_function GO:0015145 monosaccharide transmembrane transporter activity; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # INDUCTION LSRC_ECOLI In the absence of AI-2, repressed by LsrR. Induced by AI-2, via release of the LsrR repressor. In the absence of glucose, induced by cAMP-CRP by direct binding to the upstream region of the lsr promoter. {ECO 0000269|PubMed 15601708, ECO 0000269|PubMed 15743955}. # InterPro IPR001851 ABC_transp_permease # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00219 AI-2 transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism LSRC_ECOLI Escherichia coli (strain K12) # PATRIC 32118324 VBIEscCol129921_1582 # PIR E64905 E64905 # Pfam PF02653 BPD_transp_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LSRC_ECOLI Autoinducer 2 import system permease protein LsrC # RefSeq NP_416031 NC_000913.3 # RefSeq WP_000911184 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION LSRC_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT The complex is composed of two ATP-binding proteins (LsrA), two transmembrane proteins (LsrC and LsrD) and a solute- binding protein (LsrB). {ECO 0000305}. # TCDB 3.A.1.2 the atp-binding cassette (abc) superfamily # eggNOG COG1172 LUCA # eggNOG ENOG41071MT Bacteria BLAST swissprot:LSRC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LSRC_ECOLI BioCyc ECOL316407:JW1507-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1507-MONOMER BioCyc EcoCyc:YDEY-MONOMER http://biocyc.org/getid?id=EcoCyc:YDEY-MONOMER BioCyc MetaCyc:YDEY-MONOMER http://biocyc.org/getid?id=MetaCyc:YDEY-MONOMER COG COG1172 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1172 DIP DIP-11689N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11689N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.187.1.238-248.2005 http://dx.doi.org/10.1128/JB.187.1.238-248.2005 DOI 10.1128/JB.187.6.2066-2076.2005 http://dx.doi.org/10.1128/JB.187.6.2066-2076.2005 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3568 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3568 EcoGene EG13807 http://www.ecogene.org/geneInfo.php?eg_id=EG13807 EnsemblBacteria AAC74587 http://www.ensemblgenomes.org/id/AAC74587 EnsemblBacteria AAC74587 http://www.ensemblgenomes.org/id/AAC74587 EnsemblBacteria BAA15201 http://www.ensemblgenomes.org/id/BAA15201 EnsemblBacteria BAA15201 http://www.ensemblgenomes.org/id/BAA15201 EnsemblBacteria BAA15201 http://www.ensemblgenomes.org/id/BAA15201 EnsemblBacteria b1514 http://www.ensemblgenomes.org/id/b1514 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015145 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GeneID 946105 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946105 HOGENOM HOG000212232 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000212232&db=HOGENOM6 InParanoid P77672 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77672 InterPro IPR001851 http://www.ebi.ac.uk/interpro/entry/IPR001851 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1507 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1507 KEGG_Gene eco:b1514 http://www.genome.jp/dbget-bin/www_bget?eco:b1514 KEGG_Orthology KO:K10556 http://www.genome.jp/dbget-bin/www_bget?KO:K10556 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA HQRALKY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HQRALKY PSORT swissprot:LSRC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LSRC_ECOLI PSORT-B swissprot:LSRC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LSRC_ECOLI PSORT2 swissprot:LSRC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LSRC_ECOLI Pfam PF02653 http://pfam.xfam.org/family/PF02653 Phobius swissprot:LSRC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LSRC_ECOLI PhylomeDB P77672 http://phylomedb.org/?seqid=P77672 ProteinModelPortal P77672 http://www.proteinmodelportal.org/query/uniprot/P77672 PubMed 15601708 http://www.ncbi.nlm.nih.gov/pubmed/15601708 PubMed 15743955 http://www.ncbi.nlm.nih.gov/pubmed/15743955 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416031 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416031 RefSeq WP_000911184 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000911184 STRING 511145.b1514 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1514&targetmode=cogs STRING COG1172 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1172&targetmode=cogs TCDB 3.A.1.2 http://www.tcdb.org/search/result.php?tc=3.A.1.2 UniProtKB LSRC_ECOLI http://www.uniprot.org/uniprot/LSRC_ECOLI UniProtKB-AC P77672 http://www.uniprot.org/uniprot/P77672 charge swissprot:LSRC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LSRC_ECOLI eggNOG COG1172 http://eggnogapi.embl.de/nog_data/html/tree/COG1172 eggNOG ENOG41071MT http://eggnogapi.embl.de/nog_data/html/tree/ENOG41071MT epestfind swissprot:LSRC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LSRC_ECOLI garnier swissprot:LSRC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LSRC_ECOLI helixturnhelix swissprot:LSRC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LSRC_ECOLI hmoment swissprot:LSRC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LSRC_ECOLI iep swissprot:LSRC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LSRC_ECOLI inforesidue swissprot:LSRC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LSRC_ECOLI octanol swissprot:LSRC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LSRC_ECOLI pepcoil swissprot:LSRC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LSRC_ECOLI pepdigest swissprot:LSRC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LSRC_ECOLI pepinfo swissprot:LSRC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LSRC_ECOLI pepnet swissprot:LSRC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LSRC_ECOLI pepstats swissprot:LSRC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LSRC_ECOLI pepwheel swissprot:LSRC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LSRC_ECOLI pepwindow swissprot:LSRC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LSRC_ECOLI sigcleave swissprot:LSRC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LSRC_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES ALAA_ECOLI Kinetic parameters KM=0.55 mM for pyruvate (at 37 degrees Celsius and pH 8.5) {ECO 0000269|PubMed 20729367}; KM=4.9 mM for alanine (at 37 degrees Celsius and pH 8.5) {ECO 0000269|PubMed 20729367}; # CATALYTIC ACTIVITY ALAA_ECOLI L-alanine + 2-oxoglutarate = pyruvate + L- glutamate. # COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI 597326; Evidence={ECO:0000250}; # EcoGene EG14101 alaA # FUNCTION ALAA_ECOLI Involved in the biosynthesis of alanine. {ECO 0000269|PubMed 20729367}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function ALAA_ECOLI GO 0004021 L-alanine 2-oxoglutarate aminotransferase activity; IDA UniProtKB. # GO_function GO:0008483 transaminase activity; IMP:EcoliWiki. # GO_function GO:0030170 pyridoxal phosphate binding; IDA:EcoCyc. # GO_process GO:0006523 alanine biosynthetic process; IMP:EcoliWiki. # GO_process GO:0006974 cellular response to DNA damage stimulus; IMP:EcoCyc. # GO_process GO:0019272 L-alanine biosynthetic process from pyruvate; IMP:EcoCyc. # GO_process GO:0030632 D-alanine biosynthetic process; IMP:UniProtKB. # GO_process GO:0046677 response to antibiotic; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.640.10 -; 1. # Gene3D 3.90.1150.10 -; 1. # INDUCTION Modestly repressed by alanine and leucine via Lrp. {ECO:0000269|PubMed 20729367}. # IntAct P0A959 10 # InterPro IPR004839 Aminotransferase_I/II # InterPro IPR015421 PyrdxlP-dep_Trfase_major_sub1 # InterPro IPR015422 PyrdxlP-dep_Trfase_major_sub2 # InterPro IPR015424 PyrdxlP-dep_Trfase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01007 Amino acid related enzymes # KEGG_Pathway ko00250 Alanine, aspartate and glutamate metabolism # KEGG_Pathway ko00290 Valine, leucine and isoleucine biosynthesis # Organism ALAA_ECOLI Escherichia coli (strain K12) # PATRIC 32119949 VBIEscCol129921_2384 # PDB 4CVQ X-ray; 2.11 A; A/B=1-405 # PIR H65000 H65000 # Pfam PF00155 Aminotran_1_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ALAA_ECOLI Glutamate-pyruvate aminotransferase AlaA # RefSeq NP_416793 NC_000913.3 # RefSeq WP_000074527 NZ_LN832404.1 # SIMILARITY Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. {ECO 0000305}. # SUBCELLULAR LOCATION ALAA_ECOLI Cytoplasm {ECO 0000250}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 20729367}. # SUPFAM SSF53383 SSF53383 # eggNOG COG0436 LUCA # eggNOG ENOG4105CHM Bacteria BLAST swissprot:ALAA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ALAA_ECOLI BioCyc ECOL316407:JW2287-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2287-MONOMER BioCyc EcoCyc:G7184-MONOMER http://biocyc.org/getid?id=EcoCyc:G7184-MONOMER BioCyc MetaCyc:G7184-MONOMER http://biocyc.org/getid?id=MetaCyc:G7184-MONOMER COG COG0436 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0436 DIP DIP-11970N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11970N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00738-10 http://dx.doi.org/10.1128/JB.00738-10 EC_number EC:2.6.1.2 http://www.genome.jp/dbget-bin/www_bget?EC:2.6.1.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.6.1.2 http://enzyme.expasy.org/EC/2.6.1.2 EchoBASE EB3854 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3854 EcoGene EG14101 http://www.ecogene.org/geneInfo.php?eg_id=EG14101 EnsemblBacteria AAC75350 http://www.ensemblgenomes.org/id/AAC75350 EnsemblBacteria AAC75350 http://www.ensemblgenomes.org/id/AAC75350 EnsemblBacteria BAA16127 http://www.ensemblgenomes.org/id/BAA16127 EnsemblBacteria BAA16127 http://www.ensemblgenomes.org/id/BAA16127 EnsemblBacteria BAA16127 http://www.ensemblgenomes.org/id/BAA16127 EnsemblBacteria b2290 http://www.ensemblgenomes.org/id/b2290 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004021 GO_function GO:0008483 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008483 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_process GO:0006523 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006523 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0019272 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019272 GO_process GO:0030632 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030632 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.640.10 http://www.cathdb.info/version/latest/superfamily/3.40.640.10 Gene3D 3.90.1150.10 http://www.cathdb.info/version/latest/superfamily/3.90.1150.10 GeneID 946772 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946772 HOGENOM HOG000223042 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000223042&db=HOGENOM6 InParanoid P0A959 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A959 IntAct P0A959 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A959* IntEnz 2.6.1.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.6.1.2 InterPro IPR004839 http://www.ebi.ac.uk/interpro/entry/IPR004839 InterPro IPR015421 http://www.ebi.ac.uk/interpro/entry/IPR015421 InterPro IPR015422 http://www.ebi.ac.uk/interpro/entry/IPR015422 InterPro IPR015424 http://www.ebi.ac.uk/interpro/entry/IPR015424 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Gene ecj:JW2287 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2287 KEGG_Gene eco:b2290 http://www.genome.jp/dbget-bin/www_bget?eco:b2290 KEGG_Orthology KO:K14260 http://www.genome.jp/dbget-bin/www_bget?KO:K14260 KEGG_Pathway ko00250 http://www.genome.jp/kegg-bin/show_pathway?ko00250 KEGG_Pathway ko00290 http://www.genome.jp/kegg-bin/show_pathway?ko00290 KEGG_Reaction rn:R00258 http://www.genome.jp/dbget-bin/www_bget?rn:R00258 KEGG_Reaction rn:R01215 http://www.genome.jp/dbget-bin/www_bget?rn:R01215 OMA NVPGQWA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NVPGQWA PDB 4CVQ http://www.ebi.ac.uk/pdbe-srv/view/entry/4CVQ PDBsum 4CVQ http://www.ebi.ac.uk/pdbsum/4CVQ PSORT swissprot:ALAA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ALAA_ECOLI PSORT-B swissprot:ALAA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ALAA_ECOLI PSORT2 swissprot:ALAA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ALAA_ECOLI Pfam PF00155 http://pfam.xfam.org/family/PF00155 Phobius swissprot:ALAA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ALAA_ECOLI PhylomeDB P0A959 http://phylomedb.org/?seqid=P0A959 ProteinModelPortal P0A959 http://www.proteinmodelportal.org/query/uniprot/P0A959 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20729367 http://www.ncbi.nlm.nih.gov/pubmed/20729367 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416793 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416793 RefSeq WP_000074527 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000074527 SMR P0A959 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A959 STRING 511145.b2290 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2290&targetmode=cogs STRING COG0436 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0436&targetmode=cogs SUPFAM SSF53383 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53383 UniProtKB ALAA_ECOLI http://www.uniprot.org/uniprot/ALAA_ECOLI UniProtKB-AC P0A959 http://www.uniprot.org/uniprot/P0A959 charge swissprot:ALAA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ALAA_ECOLI eggNOG COG0436 http://eggnogapi.embl.de/nog_data/html/tree/COG0436 eggNOG ENOG4105CHM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CHM epestfind swissprot:ALAA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ALAA_ECOLI garnier swissprot:ALAA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ALAA_ECOLI helixturnhelix swissprot:ALAA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ALAA_ECOLI hmoment swissprot:ALAA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ALAA_ECOLI iep swissprot:ALAA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ALAA_ECOLI inforesidue swissprot:ALAA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ALAA_ECOLI octanol swissprot:ALAA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ALAA_ECOLI pepcoil swissprot:ALAA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ALAA_ECOLI pepdigest swissprot:ALAA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ALAA_ECOLI pepinfo swissprot:ALAA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ALAA_ECOLI pepnet swissprot:ALAA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ALAA_ECOLI pepstats swissprot:ALAA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ALAA_ECOLI pepwheel swissprot:ALAA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ALAA_ECOLI pepwindow swissprot:ALAA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ALAA_ECOLI sigcleave swissprot:ALAA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ALAA_ECOLI ## Database ID URL or Descriptions # AltName YHAC_ECOLI ORF B' # AltName YHAC_ECOLI ORFX # BioGrid 4259490 11 # EcoGene EG11174 yhaC # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_process GO:0006950 response to stress # Organism YHAC_ECOLI Escherichia coli (strain K12) # PATRIC 32121658 VBIEscCol129921_3215 # PIR JU0026 Q0ECTR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHAC_ECOLI Uncharacterized protein YhaC # RefSeq NP_417591 NC_000913.3 # RefSeq WP_000484600 NZ_LN832404.1 BLAST swissprot:YHAC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHAC_ECOLI BioCyc ECOL316407:JW3092-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3092-MONOMER BioCyc EcoCyc:EG11174-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11174-MONOMER DOI 10.1007/BF00332418 http://dx.doi.org/10.1007/BF00332418 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.80.17.5359 http://dx.doi.org/10.1073/pnas.80.17.5359 DOI 10.1093/nar/17.10.3994 http://dx.doi.org/10.1093/nar/17.10.3994 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D90212 http://www.ebi.ac.uk/ena/data/view/D90212 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X14430 http://www.ebi.ac.uk/ena/data/view/X14430 EMBL X16445 http://www.ebi.ac.uk/ena/data/view/X16445 EchoBASE EB1161 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1161 EcoGene EG11174 http://www.ecogene.org/geneInfo.php?eg_id=EG11174 EnsemblBacteria AAC76156 http://www.ensemblgenomes.org/id/AAC76156 EnsemblBacteria AAC76156 http://www.ensemblgenomes.org/id/AAC76156 EnsemblBacteria BAE77170 http://www.ensemblgenomes.org/id/BAE77170 EnsemblBacteria BAE77170 http://www.ensemblgenomes.org/id/BAE77170 EnsemblBacteria BAE77170 http://www.ensemblgenomes.org/id/BAE77170 EnsemblBacteria b3121 http://www.ensemblgenomes.org/id/b3121 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 947557 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947557 HOGENOM HOG000009598 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009598&db=HOGENOM6 KEGG_Gene ecj:JW3092 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3092 KEGG_Gene eco:b3121 http://www.genome.jp/dbget-bin/www_bget?eco:b3121 OMA EDYTYNY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EDYTYNY PSORT swissprot:YHAC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHAC_ECOLI PSORT-B swissprot:YHAC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHAC_ECOLI PSORT2 swissprot:YHAC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHAC_ECOLI Phobius swissprot:YHAC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHAC_ECOLI ProteinModelPortal P11864 http://www.proteinmodelportal.org/query/uniprot/P11864 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1705543 http://www.ncbi.nlm.nih.gov/pubmed/1705543 PubMed 2573820 http://www.ncbi.nlm.nih.gov/pubmed/2573820 PubMed 2660107 http://www.ncbi.nlm.nih.gov/pubmed/2660107 PubMed 6351058 http://www.ncbi.nlm.nih.gov/pubmed/6351058 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417591 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417591 RefSeq WP_000484600 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000484600 SMR P11864 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P11864 STRING 511145.b3121 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3121&targetmode=cogs UniProtKB YHAC_ECOLI http://www.uniprot.org/uniprot/YHAC_ECOLI UniProtKB-AC P11864 http://www.uniprot.org/uniprot/P11864 charge swissprot:YHAC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHAC_ECOLI epestfind swissprot:YHAC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHAC_ECOLI garnier swissprot:YHAC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHAC_ECOLI helixturnhelix swissprot:YHAC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHAC_ECOLI hmoment swissprot:YHAC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHAC_ECOLI iep swissprot:YHAC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHAC_ECOLI inforesidue swissprot:YHAC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHAC_ECOLI octanol swissprot:YHAC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHAC_ECOLI pepcoil swissprot:YHAC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHAC_ECOLI pepdigest swissprot:YHAC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHAC_ECOLI pepinfo swissprot:YHAC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHAC_ECOLI pepnet swissprot:YHAC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHAC_ECOLI pepstats swissprot:YHAC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHAC_ECOLI pepwheel swissprot:YHAC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHAC_ECOLI pepwindow swissprot:YHAC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHAC_ECOLI sigcleave swissprot:YHAC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHAC_ECOLI ## Database ID URL or Descriptions # AltName TNR1_ECOLI Transposon Tn1000 resolvase # FUNCTION TNR1_ECOLI This protein catalyzes the site-specific recombination of the transposon and also regulates its frequency of transposition. # GO_function GO:0000150 recombinase activity; IEA:InterPro. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0015074 DNA integration; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # Gene3D 1.10.10.60 -; 1. # Gene3D 3.40.50.1390 -; 1. # InterPro IPR006118 Recombinase_CS # InterPro IPR006119 Resolv_N # InterPro IPR006120 Resolvase_HTH_dom # InterPro IPR009057 Homeodomain-like # Organism TNR1_ECOLI Escherichia coli (strain K12) # PDB 1GDR X-ray; 3.50 A; A=1-140 # PDB 1GDT X-ray; 3.00 A; A/B=1-183 # PDB 1GHT NMR; -; A=1-105 # PDB 1HX7 NMR; -; A=1-105 # PDB 1RES NMR; -; A=141-183 # PDB 1RET NMR; -; A=141-183 # PDB 1ZR2 X-ray; 3.90 A; A/B=1-183 # PDB 1ZR4 X-ray; 3.40 A; A/B/D/E=1-183 # PDB 2GM4 X-ray; 3.50 A; A/B=1-183 # PDB 2GM5 X-ray; 2.10 A; A/B/C/D=2-134 # PDB 2RSL X-ray; 2.30 A; A/B/C=1-140 # PIR A03542 RPECTG # PROSITE PS00397 RECOMBINASES_1 # PROSITE PS00398 RECOMBINASES_2 # PROSITE PS51736 RECOMBINASES_3 # Pfam PF00239 Resolvase # Pfam PF02796 HTH_7 # RecName TNR1_ECOLI Transposon gamma-delta resolvase # RefSeq NP_061388 NC_002483.1 # RefSeq WP_001235704 NZ_CP014273.1 # SIMILARITY Belongs to the site-specific recombinase resolvase family. {ECO 0000305}. # SIMILARITY Contains 1 resolvase/invertase-type recombinase catalytic domain. {ECO:0000255|PROSITE-ProRule PRU01072}. # SMART SM00857 Resolvase # SUPFAM SSF46689 SSF46689 # SUPFAM SSF53041 SSF53041 # eggNOG COG1961 LUCA # eggNOG ENOG4108C33 Bacteria BLAST swissprot:TNR1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TNR1_ECOLI BioCyc ECOL316385:GJ8B-1333-MONOMER http://biocyc.org/getid?id=ECOL316385:GJ8B-1333-MONOMER DIP DIP-61217N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-61217N DOI 10.1002/pro.5560030815 http://dx.doi.org/10.1002/pro.5560030815 DOI 10.1016/0092-8674(84)90501-4 http://dx.doi.org/10.1016/0092-8674(84)90501-4 DOI 10.1016/0092-8674(90)90427-G http://dx.doi.org/10.1016/0092-8674(90)90427-G DOI 10.1016/0092-8674(95)90307-0 http://dx.doi.org/10.1016/0092-8674(95)90307-0 DOI 10.1038/300381a0 http://dx.doi.org/10.1038/300381a0 DOI 10.1266/jjg.69.269 http://dx.doi.org/10.1266/jjg.69.269 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL D16449 http://www.ebi.ac.uk/ena/data/view/D16449 EMBL J01844 http://www.ebi.ac.uk/ena/data/view/J01844 EMBL X60200 http://www.ebi.ac.uk/ena/data/view/X60200 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000150 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0015074 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015074 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 Gene3D 3.40.50.1390 http://www.cathdb.info/version/latest/superfamily/3.40.50.1390 GeneID 1263577 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263577 HOGENOM HOG000275578 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275578&db=HOGENOM6 InterPro IPR006118 http://www.ebi.ac.uk/interpro/entry/IPR006118 InterPro IPR006119 http://www.ebi.ac.uk/interpro/entry/IPR006119 InterPro IPR006120 http://www.ebi.ac.uk/interpro/entry/IPR006120 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 OMA RKQGMTY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RKQGMTY PDB 1GDR http://www.ebi.ac.uk/pdbe-srv/view/entry/1GDR PDB 1GDT http://www.ebi.ac.uk/pdbe-srv/view/entry/1GDT PDB 1GHT http://www.ebi.ac.uk/pdbe-srv/view/entry/1GHT PDB 1HX7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1HX7 PDB 1RES http://www.ebi.ac.uk/pdbe-srv/view/entry/1RES PDB 1RET http://www.ebi.ac.uk/pdbe-srv/view/entry/1RET PDB 1ZR2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZR2 PDB 1ZR4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZR4 PDB 2GM4 http://www.ebi.ac.uk/pdbe-srv/view/entry/2GM4 PDB 2GM5 http://www.ebi.ac.uk/pdbe-srv/view/entry/2GM5 PDB 2RSL http://www.ebi.ac.uk/pdbe-srv/view/entry/2RSL PDBsum 1GDR http://www.ebi.ac.uk/pdbsum/1GDR PDBsum 1GDT http://www.ebi.ac.uk/pdbsum/1GDT PDBsum 1GHT http://www.ebi.ac.uk/pdbsum/1GHT PDBsum 1HX7 http://www.ebi.ac.uk/pdbsum/1HX7 PDBsum 1RES http://www.ebi.ac.uk/pdbsum/1RES PDBsum 1RET http://www.ebi.ac.uk/pdbsum/1RET PDBsum 1ZR2 http://www.ebi.ac.uk/pdbsum/1ZR2 PDBsum 1ZR4 http://www.ebi.ac.uk/pdbsum/1ZR4 PDBsum 2GM4 http://www.ebi.ac.uk/pdbsum/2GM4 PDBsum 2GM5 http://www.ebi.ac.uk/pdbsum/2GM5 PDBsum 2RSL http://www.ebi.ac.uk/pdbsum/2RSL PROSITE PS00397 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00397 PROSITE PS00398 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00398 PROSITE PS51736 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51736 PSORT swissprot:TNR1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TNR1_ECOLI PSORT-B swissprot:TNR1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TNR1_ECOLI PSORT2 swissprot:TNR1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TNR1_ECOLI Pfam PF00239 http://pfam.xfam.org/family/PF00239 Pfam PF02796 http://pfam.xfam.org/family/PF02796 Phobius swissprot:TNR1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TNR1_ECOLI PhylomeDB P03012 http://phylomedb.org/?seqid=P03012 ProteinModelPortal P03012 http://www.proteinmodelportal.org/query/uniprot/P03012 PubMed 2175678 http://www.ncbi.nlm.nih.gov/pubmed/2175678 PubMed 6088082 http://www.ncbi.nlm.nih.gov/pubmed/6088082 PubMed 6099239 http://www.ncbi.nlm.nih.gov/pubmed/6099239 PubMed 6292730 http://www.ncbi.nlm.nih.gov/pubmed/6292730 PubMed 7612932 http://www.ncbi.nlm.nih.gov/pubmed/7612932 PubMed 7628011 http://www.ncbi.nlm.nih.gov/pubmed/7628011 PubMed 7987224 http://www.ncbi.nlm.nih.gov/pubmed/7987224 PubMed 8080658 http://www.ncbi.nlm.nih.gov/pubmed/8080658 RefSeq NP_061388 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061388 RefSeq WP_001235704 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001235704 SMART SM00857 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00857 SMR P03012 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P03012 STRING 316385.ECDH10B_1363 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316385.ECDH10B_1363&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF53041 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53041 UniProtKB TNR1_ECOLI http://www.uniprot.org/uniprot/TNR1_ECOLI UniProtKB-AC P03012 http://www.uniprot.org/uniprot/P03012 charge swissprot:TNR1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TNR1_ECOLI eggNOG COG1961 http://eggnogapi.embl.de/nog_data/html/tree/COG1961 eggNOG ENOG4108C33 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108C33 epestfind swissprot:TNR1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TNR1_ECOLI garnier swissprot:TNR1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TNR1_ECOLI helixturnhelix swissprot:TNR1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TNR1_ECOLI hmoment swissprot:TNR1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TNR1_ECOLI iep swissprot:TNR1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TNR1_ECOLI inforesidue swissprot:TNR1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TNR1_ECOLI octanol swissprot:TNR1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TNR1_ECOLI pepcoil swissprot:TNR1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TNR1_ECOLI pepdigest swissprot:TNR1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TNR1_ECOLI pepinfo swissprot:TNR1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TNR1_ECOLI pepnet swissprot:TNR1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TNR1_ECOLI pepstats swissprot:TNR1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TNR1_ECOLI pepwheel swissprot:TNR1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TNR1_ECOLI pepwindow swissprot:TNR1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TNR1_ECOLI sigcleave swissprot:TNR1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TNR1_ECOLI ## Database ID URL or Descriptions # AltName CHRR_ECOLI NAD(P)H dehydrogenase (quinone) # BIOPHYSICOCHEMICAL PROPERTIES CHRR_ECOLI Kinetic parameters KM=108 uM for uranate (at pH 7 and 37 degrees Celsius. PubMed 17088379) {ECO 0000269|PubMed 14766567, ECO 0000269|PubMed 17088379}; KM=200 uM for chromate (at pH 5 and 35 degrees Celsius. PubMed 14766567) {ECO 0000269|PubMed 14766567, ECO 0000269|PubMed 17088379}; KM=376 uM for chromate (at pH 7 and 37 degrees Celsius. PubMed 17088379) {ECO 0000269|PubMed 14766567, ECO 0000269|PubMed 17088379}; Vmax=5 umol/min/mg enzyme with chromate as substrate (at pH 5 and 35 degrees Celsius. PubMed 14766567) {ECO 0000269|PubMed 14766567, ECO 0000269|PubMed 17088379}; Vmax=213 umol/min/mg enzyme with uranate as substrate (at pH 7 and 37 degrees Celsius. PubMed 17088379) {ECO 0000269|PubMed 14766567, ECO 0000269|PubMed 17088379}; Vmax=295 umol/min/mg enzyme with chromate as substrate (at pH 7 and 37 degrees Celsius. PubMed 17088379) {ECO 0000269|PubMed 14766567, ECO 0000269|PubMed 17088379}; Note=Kcat is 3.7 sec(-1) for reductase activity with chromate (at pH 5 and 35 degrees Celsius. PubMed 14766567). Kcat is 29 sec(-1) for reductase activity with uranate (at pH 7 and 37 degrees Celsius. PubMed 17088379). Kcat is 30 sec(-1) for reductase activity with chromate (at pH 7 and 37 degrees Celsius. PubMed 17088379).; pH dependence Optimum pH is 5. {ECO 0000269|PubMed 14766567, ECO 0000269|PubMed 17088379}; Temperature dependence Optimum temperature is 35 degrees Celsius. {ECO 0000269|PubMed 14766567, ECO 0000269|PubMed 17088379}; # BioGrid 4262171 9 # CATALYTIC ACTIVITY CHRR_ECOLI 2 NAD(P)H + Cr(6+) + O(2) = 2 NAD(P)(+) + Cr(3+) + H(2)O(2). # CATALYTIC ACTIVITY CHRR_ECOLI NAD(P)H + a quinone = NAD(P)(+) + a hydroquinone. # COFACTOR CHRR_ECOLI Name=FMN; Xref=ChEBI CHEBI 58210; Evidence={ECO 0000269|PubMed 14766567}; Note=Binds 1 FMN per subunit. {ECO 0000269|PubMed 14766567}; # DISRUPTION PHENOTYPE Cells lacking this gene show an increased sensitivity to chromate. {ECO:0000269|PubMed 16621832}. # ENZYME REGULATION Inhibited by divalent cations. {ECO:0000269|PubMed 14766567}. # EcoGene EG11723 chrR # FUNCTION CHRR_ECOLI Involved in the protection against chromate toxicity. Catalyzes the transfer of three electrons to Cr(6+) producing Cr(3+) and one electron to molecular oxygen without producing the toxic Cr(5+) species and only producing a minimal amount of reactive oxygen species (ROS). It can also reduce quinones, potassium ferricyanide, 2,6-dichloroindophenol, V(5+), Mo(6+), methylene blue and cytochrome c. The quinone reductase activity may protect against oxidative stress by preventing redox cycling of quinones which would otherwise generate ROS and by maintaining a pool of reduced quinone in the cell that is able to quench ROS directly. It is able to use both NAD or NADP equally well. {ECO 0000269|PubMed 14766567, ECO 0000269|PubMed 16621832, ECO 0000269|PubMed 17088379, ECO 0000269|PubMed 22558308}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003955 NAD(P)H dehydrogenase (quinone) activity; IEA:UniProtKB-EC. # GO_function GO:0010181 FMN binding; IDA:EcoCyc. # GO_function GO:0016491 oxidoreductase activity; IDA:EcoCyc. # GO_function GO:0052873 FMN reductase (NADPH) activity; IBA:GO_Central. # GO_process GO:0006805 xenobiotic metabolic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.360 -; 1. # INDUCTION Induced by both chromate and the stationary phase. {ECO:0000269|PubMed 14766567}. # IntAct P0AGE6 2 # InterPro IPR005025 FMN_Rdtase-like # InterPro IPR029039 Flavoprotein-like_dom # Organism CHRR_ECOLI Escherichia coli (strain K12) # PATRIC 32122921 VBIEscCol129921_3836 # PDB 3SVL X-ray; 2.20 A; A/B=3-188 # PIR B65174 B65174 # Pfam PF03358 FMN_red # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CHRR_ECOLI Chromate reductase # RefSeq NP_418169 NC_000913.3 # RefSeq WP_001291268 NZ_LN832404.1 # SIMILARITY Belongs to the SsuE family. {ECO 0000305}. # SUBUNIT Homotetramer. Dimer of dimers. The tetrameric configuration has a central role in chromate reductase activity. {ECO:0000269|PubMed 22558308}. # SUPFAM SSF52218 SSF52218 # eggNOG COG0431 LUCA # eggNOG ENOG4108YYH Bacteria BLAST swissprot:CHRR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CHRR_ECOLI BioCyc ECOL316407:JW3691-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3691-MONOMER BioCyc EcoCyc:EG11723-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11723-MONOMER BioCyc MetaCyc:EG11723-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11723-MONOMER DIP DIP-36041N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36041N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AEM.01334-06 http://dx.doi.org/10.1128/AEM.01334-06 DOI 10.1128/AEM.70.2.873-882.2004 http://dx.doi.org/10.1128/AEM.70.2.873-882.2004 DOI 10.1128/JB.188.9.3371-3381.2006 http://dx.doi.org/10.1128/JB.188.9.3371-3381.2006 DOI 10.1371/journal.pone.0036017 http://dx.doi.org/10.1371/journal.pone.0036017 EC_number EC:1.6.5.2 http://www.genome.jp/dbget-bin/www_bget?EC:1.6.5.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.6.5.2 http://enzyme.expasy.org/EC/1.6.5.2 EchoBASE EB1674 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1674 EcoGene EG11723 http://www.ecogene.org/geneInfo.php?eg_id=EG11723 EnsemblBacteria AAC76736 http://www.ensemblgenomes.org/id/AAC76736 EnsemblBacteria AAC76736 http://www.ensemblgenomes.org/id/AAC76736 EnsemblBacteria BAE77575 http://www.ensemblgenomes.org/id/BAE77575 EnsemblBacteria BAE77575 http://www.ensemblgenomes.org/id/BAE77575 EnsemblBacteria BAE77575 http://www.ensemblgenomes.org/id/BAE77575 EnsemblBacteria b3713 http://www.ensemblgenomes.org/id/b3713 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003955 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003955 GO_function GO:0010181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010181 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0052873 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052873 GO_process GO:0006805 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006805 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.360 http://www.cathdb.info/version/latest/superfamily/3.40.50.360 GeneID 948225 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948225 HOGENOM HOG000263119 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000263119&db=HOGENOM6 InParanoid P0AGE6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGE6 IntAct P0AGE6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AGE6* IntEnz 1.6.5.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.6.5.2 InterPro IPR005025 http://www.ebi.ac.uk/interpro/entry/IPR005025 InterPro IPR029039 http://www.ebi.ac.uk/interpro/entry/IPR029039 KEGG_Gene ecj:JW3691 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3691 KEGG_Gene eco:b3713 http://www.genome.jp/dbget-bin/www_bget?eco:b3713 OMA NKVDTQT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NKVDTQT PDB 3SVL http://www.ebi.ac.uk/pdbe-srv/view/entry/3SVL PDBsum 3SVL http://www.ebi.ac.uk/pdbsum/3SVL PSORT swissprot:CHRR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CHRR_ECOLI PSORT-B swissprot:CHRR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CHRR_ECOLI PSORT2 swissprot:CHRR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CHRR_ECOLI Pfam PF03358 http://pfam.xfam.org/family/PF03358 Phobius swissprot:CHRR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CHRR_ECOLI PhylomeDB P0AGE6 http://phylomedb.org/?seqid=P0AGE6 ProteinModelPortal P0AGE6 http://www.proteinmodelportal.org/query/uniprot/P0AGE6 PubMed 14766567 http://www.ncbi.nlm.nih.gov/pubmed/14766567 PubMed 16621832 http://www.ncbi.nlm.nih.gov/pubmed/16621832 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17088379 http://www.ncbi.nlm.nih.gov/pubmed/17088379 PubMed 22558308 http://www.ncbi.nlm.nih.gov/pubmed/22558308 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418169 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418169 RefSeq WP_001291268 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001291268 SMR P0AGE6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AGE6 STRING 511145.b3713 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3713&targetmode=cogs SUPFAM SSF52218 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52218 UniProtKB CHRR_ECOLI http://www.uniprot.org/uniprot/CHRR_ECOLI UniProtKB-AC P0AGE6 http://www.uniprot.org/uniprot/P0AGE6 charge swissprot:CHRR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CHRR_ECOLI eggNOG COG0431 http://eggnogapi.embl.de/nog_data/html/tree/COG0431 eggNOG ENOG4108YYH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108YYH epestfind swissprot:CHRR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CHRR_ECOLI garnier swissprot:CHRR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CHRR_ECOLI helixturnhelix swissprot:CHRR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CHRR_ECOLI hmoment swissprot:CHRR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CHRR_ECOLI iep swissprot:CHRR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CHRR_ECOLI inforesidue swissprot:CHRR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CHRR_ECOLI octanol swissprot:CHRR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CHRR_ECOLI pepcoil swissprot:CHRR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CHRR_ECOLI pepdigest swissprot:CHRR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CHRR_ECOLI pepinfo swissprot:CHRR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CHRR_ECOLI pepnet swissprot:CHRR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CHRR_ECOLI pepstats swissprot:CHRR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CHRR_ECOLI pepwheel swissprot:CHRR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CHRR_ECOLI pepwindow swissprot:CHRR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CHRR_ECOLI sigcleave swissprot:CHRR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CHRR_ECOLI ## Database ID URL or Descriptions # AltName PGAM {ECO:0000255|HAMAP-Rule MF_01040} # AltName Phosphoglyceromutase {ECO:0000255|HAMAP-Rule MF_01040} # BioGrid 4261680 6 # CATALYTIC ACTIVITY 2-phospho-D-glycerate = 3-phospho-D-glycerate. {ECO:0000255|HAMAP-Rule MF_01040}. # CDD cd07067 HP_PGM_like # EcoGene EG12164 gpmB # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0004619 phosphoglycerate mutase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0016791 phosphatase activity; IBA:GO_Central. # GO_process GO:0006096 glycolytic process; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.1240 -; 1. # HAMAP MF_01040 PGAM_GpmB # IntAct P0A7A2 5 # InterPro IPR001345 PG/BPGM_mutase_AS # InterPro IPR013078 His_Pase_superF_clade-1 # InterPro IPR023086 Phosphoglycerate_mutase_GpmB # InterPro IPR029033 His_PPase_superfam # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00010 Glycolysis / Gluconeogenesis # KEGG_Pathway ko00260 Glycine, serine and threonine metabolism # KEGG_Pathway ko00680 Methane metabolism # Organism GPMB_ECOLI Escherichia coli (strain K12) # PATHWAY Carbohydrate degradation; glycolysis; pyruvate from D- glyceraldehyde 3-phosphate: step 3/5. {ECO 0000255|HAMAP- Rule:MF_01040}. # PATRIC 32124408 VBIEscCol129921_4544 # PIR S56619 S56619 # PROSITE PS00175 PG_MUTASE # Pfam PF00300 His_Phos_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Probable phosphoglycerate mutase GpmB {ECO:0000255|HAMAP-Rule MF_01040} # RefSeq NP_418812 NC_000913.3 # RefSeq WP_000942344 NZ_LN832404.1 # SIMILARITY Belongs to the phosphoglycerate mutase family. GpmB subfamily. {ECO:0000255|HAMAP-Rule MF_01040}. # SMART SM00855 PGAM # SUPFAM SSF53254 SSF53254 # UniPathway UPA00109 UER00186 # eggNOG COG0406 LUCA # eggNOG ENOG4105CVJ Bacteria BLAST swissprot:GPMB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GPMB_ECOLI BioCyc ECOL316407:JW4358-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4358-MONOMER BioCyc EcoCyc:PGAM2-MONOMER http://biocyc.org/getid?id=EcoCyc:PGAM2-MONOMER COG COG0406 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0406 DIP DIP-9829N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9829N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.4.2.- {ECO:0000255|HAMAP-Rule:MF_01040} http://www.genome.jp/dbget-bin/www_bget?EC:5.4.2.- {ECO:0000255|HAMAP-Rule:MF_01040} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M97495 http://www.ebi.ac.uk/ena/data/view/M97495 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 5.4.2.- {ECO:0000255|HAMAP-Rule:MF_01040} http://enzyme.expasy.org/EC/5.4.2.- {ECO:0000255|HAMAP-Rule:MF_01040} EchoBASE EB2083 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2083 EcoGene EG12164 http://www.ecogene.org/geneInfo.php?eg_id=EG12164 EnsemblBacteria AAC77348 http://www.ensemblgenomes.org/id/AAC77348 EnsemblBacteria AAC77348 http://www.ensemblgenomes.org/id/AAC77348 EnsemblBacteria BAE78384 http://www.ensemblgenomes.org/id/BAE78384 EnsemblBacteria BAE78384 http://www.ensemblgenomes.org/id/BAE78384 EnsemblBacteria BAE78384 http://www.ensemblgenomes.org/id/BAE78384 EnsemblBacteria b4395 http://www.ensemblgenomes.org/id/b4395 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004619 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004619 GO_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GO_process GO:0006096 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006096 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.1240 http://www.cathdb.info/version/latest/superfamily/3.40.50.1240 GeneID 948918 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948918 HAMAP MF_01040 http://hamap.expasy.org/unirule/MF_01040 HOGENOM HOG000221683 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000221683&db=HOGENOM6 InParanoid P0A7A2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7A2 IntAct P0A7A2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7A2* IntEnz 5.4.2.- {ECO:0000255|HAMAP-Rule:MF_01040} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.4.2.- {ECO:0000255|HAMAP-Rule:MF_01040} InterPro IPR001345 http://www.ebi.ac.uk/interpro/entry/IPR001345 InterPro IPR013078 http://www.ebi.ac.uk/interpro/entry/IPR013078 InterPro IPR023086 http://www.ebi.ac.uk/interpro/entry/IPR023086 InterPro IPR029033 http://www.ebi.ac.uk/interpro/entry/IPR029033 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4358 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4358 KEGG_Gene eco:b4395 http://www.genome.jp/dbget-bin/www_bget?eco:b4395 KEGG_Orthology KO:K15634 http://www.genome.jp/dbget-bin/www_bget?KO:K15634 KEGG_Pathway ko00010 http://www.genome.jp/kegg-bin/show_pathway?ko00010 KEGG_Pathway ko00260 http://www.genome.jp/kegg-bin/show_pathway?ko00260 KEGG_Pathway ko00680 http://www.genome.jp/kegg-bin/show_pathway?ko00680 KEGG_Reaction rn:R01518 http://www.genome.jp/dbget-bin/www_bget?rn:R01518 MINT MINT-1235576 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1235576 OMA LGCLIST http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LGCLIST PROSITE PS00175 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00175 PSORT swissprot:GPMB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GPMB_ECOLI PSORT-B swissprot:GPMB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GPMB_ECOLI PSORT2 swissprot:GPMB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GPMB_ECOLI Pfam PF00300 http://pfam.xfam.org/family/PF00300 Phobius swissprot:GPMB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GPMB_ECOLI PhylomeDB P0A7A2 http://phylomedb.org/?seqid=P0A7A2 ProteinModelPortal P0A7A2 http://www.proteinmodelportal.org/query/uniprot/P0A7A2 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8449900 http://www.ncbi.nlm.nih.gov/pubmed/8449900 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418812 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418812 RefSeq WP_000942344 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000942344 SMART SM00855 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00855 SMR P0A7A2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7A2 STRING 511145.b4395 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4395&targetmode=cogs STRING COG0406 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0406&targetmode=cogs SUPFAM SSF53254 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53254 UniProtKB GPMB_ECOLI http://www.uniprot.org/uniprot/GPMB_ECOLI UniProtKB-AC P0A7A2 http://www.uniprot.org/uniprot/P0A7A2 charge swissprot:GPMB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GPMB_ECOLI eggNOG COG0406 http://eggnogapi.embl.de/nog_data/html/tree/COG0406 eggNOG ENOG4105CVJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CVJ epestfind swissprot:GPMB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GPMB_ECOLI garnier swissprot:GPMB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GPMB_ECOLI helixturnhelix swissprot:GPMB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GPMB_ECOLI hmoment swissprot:GPMB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GPMB_ECOLI iep swissprot:GPMB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GPMB_ECOLI inforesidue swissprot:GPMB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GPMB_ECOLI octanol swissprot:GPMB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GPMB_ECOLI pepcoil swissprot:GPMB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GPMB_ECOLI pepdigest swissprot:GPMB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GPMB_ECOLI pepinfo swissprot:GPMB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GPMB_ECOLI pepnet swissprot:GPMB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GPMB_ECOLI pepstats swissprot:GPMB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GPMB_ECOLI pepwheel swissprot:GPMB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GPMB_ECOLI pepwindow swissprot:GPMB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GPMB_ECOLI sigcleave swissprot:GPMB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GPMB_ECOLI ## Database ID URL or Descriptions # BioGrid 4261745 182 # EcoGene EG12586 yjiY # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0009267 cellular response to starvation; IEA:InterPro. # GO_process GO:0031669 cellular response to nutrient levels; IEP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # INDUCTION YJIY_ECOLI Strongly induced at the onset of the stationary-growth phase. Expression is dependent on the YehU/YehT two-component regulatory system, and on cAMP and the cAMP receptor protein (CRP). Repressed by LeuO. Monocistronic operon. {ECO 0000269|PubMed 19429622, ECO 0000269|PubMed 22685278}. # InterPro IPR003706 CstA_N # InterPro IPR025299 CstA_C # Organism YJIY_ECOLI Escherichia coli (strain K12) # PATRIC 32124314 VBIEscCol129921_4500 # PIR S56580 S56580 # Pfam PF02554 CstA # Pfam PF13722 CstA_5TM # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJIY_ECOLI Inner membrane protein YjiY # RefSeq NP_418774 NC_000913.3 # RefSeq WP_001299714 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97251.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the CstA family. {ECO 0000305}. # SUBCELLULAR LOCATION YJIY_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 22685278}; Multi- pass membrane protein {ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 22685278}. # eggNOG COG1966 LUCA # eggNOG ENOG4105D22 Bacteria BLAST swissprot:YJIY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJIY_ECOLI BioCyc ECOL316407:JW5791-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5791-MONOMER BioCyc EcoCyc:G7942-MONOMER http://biocyc.org/getid?id=EcoCyc:G7942-MONOMER DIP DIP-12649N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12649N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00108-09 http://dx.doi.org/10.1128/JB.00108-09 DOI 10.1128/JB.00409-12 http://dx.doi.org/10.1128/JB.00409-12 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2472 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2472 EcoGene EG12586 http://www.ecogene.org/geneInfo.php?eg_id=EG12586 EnsemblBacteria AAC77310 http://www.ensemblgenomes.org/id/AAC77310 EnsemblBacteria AAC77310 http://www.ensemblgenomes.org/id/AAC77310 EnsemblBacteria BAE78344 http://www.ensemblgenomes.org/id/BAE78344 EnsemblBacteria BAE78344 http://www.ensemblgenomes.org/id/BAE78344 EnsemblBacteria BAE78344 http://www.ensemblgenomes.org/id/BAE78344 EnsemblBacteria b4354 http://www.ensemblgenomes.org/id/b4354 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0009267 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009267 GO_process GO:0031669 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031669 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 948914 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948914 HOGENOM HOG000220271 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220271&db=HOGENOM6 InParanoid P39396 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39396 IntAct P39396 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39396* InterPro IPR003706 http://www.ebi.ac.uk/interpro/entry/IPR003706 InterPro IPR025299 http://www.ebi.ac.uk/interpro/entry/IPR025299 KEGG_Gene ecj:JW5791 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5791 KEGG_Gene eco:b4354 http://www.genome.jp/dbget-bin/www_bget?eco:b4354 OMA KRTKYIW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KRTKYIW PSORT swissprot:YJIY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJIY_ECOLI PSORT-B swissprot:YJIY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJIY_ECOLI PSORT2 swissprot:YJIY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJIY_ECOLI Pfam PF02554 http://pfam.xfam.org/family/PF02554 Pfam PF13722 http://pfam.xfam.org/family/PF13722 Phobius swissprot:YJIY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJIY_ECOLI PhylomeDB P39396 http://phylomedb.org/?seqid=P39396 ProteinModelPortal P39396 http://www.proteinmodelportal.org/query/uniprot/P39396 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19429622 http://www.ncbi.nlm.nih.gov/pubmed/19429622 PubMed 22685278 http://www.ncbi.nlm.nih.gov/pubmed/22685278 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418774 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418774 RefSeq WP_001299714 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001299714 STRING 511145.b4354 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4354&targetmode=cogs UniProtKB YJIY_ECOLI http://www.uniprot.org/uniprot/YJIY_ECOLI UniProtKB-AC P39396 http://www.uniprot.org/uniprot/P39396 charge swissprot:YJIY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJIY_ECOLI eggNOG COG1966 http://eggnogapi.embl.de/nog_data/html/tree/COG1966 eggNOG ENOG4105D22 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D22 epestfind swissprot:YJIY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJIY_ECOLI garnier swissprot:YJIY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJIY_ECOLI helixturnhelix swissprot:YJIY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJIY_ECOLI hmoment swissprot:YJIY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJIY_ECOLI iep swissprot:YJIY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJIY_ECOLI inforesidue swissprot:YJIY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJIY_ECOLI octanol swissprot:YJIY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJIY_ECOLI pepcoil swissprot:YJIY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJIY_ECOLI pepdigest swissprot:YJIY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJIY_ECOLI pepinfo swissprot:YJIY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJIY_ECOLI pepnet swissprot:YJIY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJIY_ECOLI pepstats swissprot:YJIY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJIY_ECOLI pepwheel swissprot:YJIY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJIY_ECOLI pepwindow swissprot:YJIY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJIY_ECOLI sigcleave swissprot:YJIY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJIY_ECOLI ## Database ID URL or Descriptions # BioGrid 4262873 9 # EcoGene EG13895 ycgN # HAMAP MF_00676 UPF0260 # InterPro IPR005358 Puta_zinc/iron-chelating_dom # InterPro IPR008228 UCP006173 # Organism YCGN_ECOLI Escherichia coli (strain K12) # PATRIC 32117608 VBIEscCol129921_1226 # PIRSF PIRSF006173 UCP006173 # Pfam PF03692 CxxCxxCC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCGN_ECOLI UPF0260 protein YcgN # RefSeq NP_415699 NC_000913.3 # RefSeq WP_000807626 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA36015.2; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the UPF0260 family. {ECO 0000305}. # eggNOG COG2983 LUCA # eggNOG ENOG4108ZZ3 Bacteria BLAST swissprot:YCGN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCGN_ECOLI BioCyc ECOL316407:JW5180-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5180-MONOMER BioCyc EcoCyc:G6618-MONOMER http://biocyc.org/getid?id=EcoCyc:G6618-MONOMER COG COG2983 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2983 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3654 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3654 EcoGene EG13895 http://www.ecogene.org/geneInfo.php?eg_id=EG13895 EnsemblBacteria AAC74265 http://www.ensemblgenomes.org/id/AAC74265 EnsemblBacteria AAC74265 http://www.ensemblgenomes.org/id/AAC74265 EnsemblBacteria BAA36015 http://www.ensemblgenomes.org/id/BAA36015 EnsemblBacteria BAA36015 http://www.ensemblgenomes.org/id/BAA36015 EnsemblBacteria BAA36015 http://www.ensemblgenomes.org/id/BAA36015 EnsemblBacteria b1181 http://www.ensemblgenomes.org/id/b1181 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945804 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945804 HAMAP MF_00676 http://hamap.expasy.org/unirule/MF_00676 HOGENOM HOG000276681 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276681&db=HOGENOM6 InParanoid P0A8L5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8L5 InterPro IPR005358 http://www.ebi.ac.uk/interpro/entry/IPR005358 InterPro IPR008228 http://www.ebi.ac.uk/interpro/entry/IPR008228 KEGG_Gene ecj:JW5180 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5180 KEGG_Gene eco:b1181 http://www.genome.jp/dbget-bin/www_bget?eco:b1181 KEGG_Orthology KO:K09160 http://www.genome.jp/dbget-bin/www_bget?KO:K09160 OMA TCQCSDY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TCQCSDY PSORT swissprot:YCGN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCGN_ECOLI PSORT-B swissprot:YCGN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCGN_ECOLI PSORT2 swissprot:YCGN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCGN_ECOLI Pfam PF03692 http://pfam.xfam.org/family/PF03692 Phobius swissprot:YCGN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCGN_ECOLI PhylomeDB P0A8L5 http://phylomedb.org/?seqid=P0A8L5 ProteinModelPortal P0A8L5 http://www.proteinmodelportal.org/query/uniprot/P0A8L5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415699 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415699 RefSeq WP_000807626 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000807626 STRING 511145.b1181 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1181&targetmode=cogs STRING COG2983 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2983&targetmode=cogs UniProtKB YCGN_ECOLI http://www.uniprot.org/uniprot/YCGN_ECOLI UniProtKB-AC P0A8L5 http://www.uniprot.org/uniprot/P0A8L5 charge swissprot:YCGN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCGN_ECOLI eggNOG COG2983 http://eggnogapi.embl.de/nog_data/html/tree/COG2983 eggNOG ENOG4108ZZ3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZZ3 epestfind swissprot:YCGN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCGN_ECOLI garnier swissprot:YCGN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCGN_ECOLI helixturnhelix swissprot:YCGN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCGN_ECOLI hmoment swissprot:YCGN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCGN_ECOLI iep swissprot:YCGN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCGN_ECOLI inforesidue swissprot:YCGN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCGN_ECOLI octanol swissprot:YCGN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCGN_ECOLI pepcoil swissprot:YCGN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCGN_ECOLI pepdigest swissprot:YCGN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCGN_ECOLI pepinfo swissprot:YCGN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCGN_ECOLI pepnet swissprot:YCGN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCGN_ECOLI pepstats swissprot:YCGN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCGN_ECOLI pepwheel swissprot:YCGN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCGN_ECOLI pepwindow swissprot:YCGN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCGN_ECOLI sigcleave swissprot:YCGN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCGN_ECOLI ## Database ID URL or Descriptions # BioGrid 4262034 9 # DISRUPTION PHENOTYPE HHA_ECOLI Deletion results in a large increase in the production of extracellular and intracellular hemolysin (PubMed 1956303). At low osmolarity minor changes in overall translation, at 0.4 M NaCl expression of about 25 proteins altered, including decreased OmpA, crr and AhpC (in strain 5K, not a K12 derivative) (PubMed 10322001). At 0.3 M NaCl in strain W3110 up-regulation of 113 genes and down-regulation of 8 genes was observed; a double cnu-hha deletion up-regulated 134 and down- regulated 5 genes, most of which are thought to have been acquired horizontally and are also up-regulated in double hns-stpA deletions (PubMed 23543115). However there are only 12 genes that were commonly up-regulated in the hha and cnu-hha deletions (PubMed 23543115). Represses the production of persister cells (PubMed 19909729). Deletion of hha and tomB (ybaJ), in the presence of a conjugative plasmid (R1drd19), decreases biofilm formation, cell aggregation and increases motility via flagella and motility gene expression (PubMed 16317765). {ECO 0000269|PubMed 10322001, ECO 0000269|PubMed 16317765, ECO 0000269|PubMed 1956303, ECO 0000269|PubMed 19909729, ECO 0000269|PubMed 23543115}. # DOMAIN HHA_ECOLI Histidine-tagging (His-tagging) at the N-terminus does not impair interaction with H-NS, whereas His-tagging at the C- terminus does impair interaction (PubMed 11790731). {ECO 0000269|PubMed 11790731}. # EcoGene EG10439 hha # FUNCTION HHA_ECOLI Down-regulates hemolysin (hly) expression in complex with H-NS (PubMed 1956303, PubMed 10778755, PubMed 11790731, PubMed 21600204). Stimulates transposition events in vivo (PubMed 8145648). Modifies the set of genes regulated by H-NS; Hha and Cnu (YdgT) increase the number of genes DNA bound by H-NS/StpA and may also modulate the oligomerization of the H-NS/StpA-complex (PubMed 23543115). Binds DNA and influences DNA topology in response to environmental stimuli; does not however interact with DNA in the absence of H-NS (PubMed 23543115). Involved in persister cell formation, acting downstream of mRNA interferase (toxin) MqsR (PubMed 19909729). Decreases biofilm formation by repressing the transcription of fimbrial genes fimA and ihfA, and by repressing the transcription of tRNAs corresponding to rare codons, which are abundant in type 1 fimbrial genes (PubMed 18545668). {ECO 0000269|PubMed 10778755, ECO 0000269|PubMed 11790731, ECO 0000269|PubMed 16317765, ECO 0000269|PubMed 18545668, ECO 0000269|PubMed 1956303, ECO 0000269|PubMed 19909729, ECO 0000269|PubMed 21600204, ECO 0000269|PubMed 23543115, ECO 0000269|PubMed 8145648}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0010468 regulation of gene expression; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.20.1280.40 -; 1. # INDUCTION HHA_ECOLI Expression is autoregulated (Probable). Induced during biofilm formation (PubMed 14727089, PubMed 18545668). {ECO 0000269|PubMed 14727089, ECO 0000269|PubMed 18545668, ECO 0000305}. # INTERACTION HHA_ECOLI P0ACF8 hns; NbExp=5; IntAct=EBI-1122578, EBI-544934; # IntAct P0ACE3 2 # InterPro IPR007985 Hemolysn_expr_modulating_HHA # MISCELLANEOUS Hha and TomB may form a toxin-antitoxin (TA) module (PubMed:18545668). {ECO 0000305|PubMed:18545668}. # Organism HHA_ECOLI Escherichia coli (strain K12) # PATRIC 32116073 VBIEscCol129921_0478 # PDB 1JW2 NMR; -; A=1-72 # PDB 2MW2 NMR; -; A=1-72 # PIR C64776 C64776 # Pfam PF05321 HHA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HHA_ECOLI Hemolysin expression-modulating protein Hha # RefSeq NP_414993 NC_000913.3 # RefSeq WP_001291435 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40215.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY HHA_ECOLI Belongs to the Hha/YmoA/Cnu family. {ECO 0000305|PubMed 1484495, ECO 0000305|PubMed 8145648}. # SUBUNIT HHA_ECOLI Forms a heterotrimeric complex with the H-NS dimer in the absence of DNA. {ECO 0000269|PubMed 10778755, ECO 0000269|PubMed 11790731, ECO 0000269|PubMed 16650431, ECO 0000269|PubMed 21600204, ECO 0000269|PubMed 26085102}. # SUPFAM SSF68989 SSF68989 # eggNOG ENOG4105KF5 Bacteria # eggNOG ENOG4111U15 LUCA BLAST swissprot:HHA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HHA_ECOLI BioCyc ECOL316407:JW0449-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0449-MONOMER BioCyc EcoCyc:EG10439-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10439-MONOMER DIP DIP-9897N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9897N DOI 10.1002/bit.20681 http://dx.doi.org/10.1002/bit.20681 DOI 10.1007/s00253-003-1517-y http://dx.doi.org/10.1007/s00253-003-1517-y DOI 10.1007/s004380051178 http://dx.doi.org/10.1007/s004380051178 DOI 10.1016/j.bbrc.2009.11.033 http://dx.doi.org/10.1016/j.bbrc.2009.11.033 DOI 10.1016/j.febslet.2011.05.024 http://dx.doi.org/10.1016/j.febslet.2011.05.024 DOI 10.1016/j.jmb.2006.03.059 http://dx.doi.org/10.1016/j.jmb.2006.03.059 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.042684599 http://dx.doi.org/10.1073/pnas.042684599 DOI 10.1074/jbc.M114.630400 http://dx.doi.org/10.1074/jbc.M114.630400 DOI 10.1093/dnares/dst008 http://dx.doi.org/10.1093/dnares/dst008 DOI 10.1111/j.1365-2958.1991.tb01902.x http://dx.doi.org/10.1111/j.1365-2958.1991.tb01902.x DOI 10.1111/j.1365-2958.1992.tb02214.x http://dx.doi.org/10.1111/j.1365-2958.1992.tb02214.x DOI 10.1111/j.1365-2958.1994.tb00291.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb00291.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.3.629-635.2002 http://dx.doi.org/10.1128/JB.184.3.629-635.2002 DOI 10.1371/journal.pone.0002394 http://dx.doi.org/10.1371/journal.pone.0002394 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL X57977 http://www.ebi.ac.uk/ena/data/view/X57977 EchoBASE EB0434 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0434 EcoGene EG10439 http://www.ecogene.org/geneInfo.php?eg_id=EG10439 EnsemblBacteria AAC73562 http://www.ensemblgenomes.org/id/AAC73562 EnsemblBacteria AAC73562 http://www.ensemblgenomes.org/id/AAC73562 EnsemblBacteria BAE76239 http://www.ensemblgenomes.org/id/BAE76239 EnsemblBacteria BAE76239 http://www.ensemblgenomes.org/id/BAE76239 EnsemblBacteria BAE76239 http://www.ensemblgenomes.org/id/BAE76239 EnsemblBacteria b0460 http://www.ensemblgenomes.org/id/b0460 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0010468 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010468 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.20.1280.40 http://www.cathdb.info/version/latest/superfamily/1.20.1280.40 GeneID 945098 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945098 HOGENOM HOG000219358 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219358&db=HOGENOM6 IntAct P0ACE3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACE3* InterPro IPR007985 http://www.ebi.ac.uk/interpro/entry/IPR007985 KEGG_Gene ecj:JW0449 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0449 KEGG_Gene eco:b0460 http://www.genome.jp/dbget-bin/www_bget?eco:b0460 KEGG_Orthology KO:K05839 http://www.genome.jp/dbget-bin/www_bget?KO:K05839 MINT MINT-8175118 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8175118 OMA RRCQSID http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RRCQSID PDB 1JW2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1JW2 PDB 2MW2 http://www.ebi.ac.uk/pdbe-srv/view/entry/2MW2 PDBsum 1JW2 http://www.ebi.ac.uk/pdbsum/1JW2 PDBsum 2MW2 http://www.ebi.ac.uk/pdbsum/2MW2 PSORT swissprot:HHA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HHA_ECOLI PSORT-B swissprot:HHA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HHA_ECOLI PSORT2 swissprot:HHA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HHA_ECOLI Pfam PF05321 http://pfam.xfam.org/family/PF05321 Phobius swissprot:HHA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HHA_ECOLI ProteinModelPortal P0ACE3 http://www.proteinmodelportal.org/query/uniprot/P0ACE3 PubMed 10322001 http://www.ncbi.nlm.nih.gov/pubmed/10322001 PubMed 10778755 http://www.ncbi.nlm.nih.gov/pubmed/10778755 PubMed 11790731 http://www.ncbi.nlm.nih.gov/pubmed/11790731 PubMed 11854485 http://www.ncbi.nlm.nih.gov/pubmed/11854485 PubMed 14727089 http://www.ncbi.nlm.nih.gov/pubmed/14727089 PubMed 1484495 http://www.ncbi.nlm.nih.gov/pubmed/1484495 PubMed 16317765 http://www.ncbi.nlm.nih.gov/pubmed/16317765 PubMed 16650431 http://www.ncbi.nlm.nih.gov/pubmed/16650431 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18545668 http://www.ncbi.nlm.nih.gov/pubmed/18545668 PubMed 1956303 http://www.ncbi.nlm.nih.gov/pubmed/1956303 PubMed 19909729 http://www.ncbi.nlm.nih.gov/pubmed/19909729 PubMed 21600204 http://www.ncbi.nlm.nih.gov/pubmed/21600204 PubMed 23543115 http://www.ncbi.nlm.nih.gov/pubmed/23543115 PubMed 26085102 http://www.ncbi.nlm.nih.gov/pubmed/26085102 PubMed 8145648 http://www.ncbi.nlm.nih.gov/pubmed/8145648 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414993 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414993 RefSeq WP_001291435 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001291435 SMR P0ACE3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACE3 STRING 511145.b0460 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0460&targetmode=cogs SUPFAM SSF68989 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF68989 UniProtKB HHA_ECOLI http://www.uniprot.org/uniprot/HHA_ECOLI UniProtKB-AC P0ACE3 http://www.uniprot.org/uniprot/P0ACE3 charge swissprot:HHA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HHA_ECOLI eggNOG ENOG4105KF5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KF5 eggNOG ENOG4111U15 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111U15 epestfind swissprot:HHA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HHA_ECOLI garnier swissprot:HHA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HHA_ECOLI helixturnhelix swissprot:HHA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HHA_ECOLI hmoment swissprot:HHA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HHA_ECOLI iep swissprot:HHA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HHA_ECOLI inforesidue swissprot:HHA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HHA_ECOLI octanol swissprot:HHA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HHA_ECOLI pepcoil swissprot:HHA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HHA_ECOLI pepdigest swissprot:HHA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HHA_ECOLI pepinfo swissprot:HHA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HHA_ECOLI pepnet swissprot:HHA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HHA_ECOLI pepstats swissprot:HHA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HHA_ECOLI pepwheel swissprot:HHA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HHA_ECOLI pepwindow swissprot:HHA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HHA_ECOLI sigcleave swissprot:HHA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HHA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259764 6 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG11496 prfH # FUNCTION RFH_ECOLI Could be involved in translational termination. # GO_function GO:0016149 translation release factor activity, codon specific; IBA:GO_Central. # GO_function GO:0043022 ribosome binding; IBA:GO_Central. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008135 translation factor activity, RNA binding # Gene3D 3.30.160.20 -; 1. # InterPro IPR000352 Pep_chain_release_fac_I_II # InterPro IPR014720 dsRBD_dom # InterPro IPR017509 Release_fac_PrfH # Organism RFH_ECOLI Escherichia coli (strain K12) # PATRIC 48659665 VBIEscCol107702_0230 # PIR E64748 E64748 # PROSITE PS00745 RF_PROK_I # Pfam PF00472 RF-1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RFH_ECOLI Putative peptide chain release factor homolog # SEQUENCE CAUTION Sequence=M34034; Type=Frameshift; Positions=32; Evidence={ECO 0000305}; # SIMILARITY Belongs to the prokaryotic/mitochondrial release factor family. {ECO 0000305}. # TIGRFAMs TIGR03072 release_prfH # eggNOG COG1186 LUCA # eggNOG ENOG4108S2Y Bacteria BLAST swissprot:RFH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RFH_ECOLI BioCyc ECOL316407:JW0226-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0226-MONOMER BioCyc EcoCyc:EG11496-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11496-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/20.17.4423 http://dx.doi.org/10.1093/nar/20.17.4423 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M34034 http://www.ebi.ac.uk/ena/data/view/M34034 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EchoBASE EB1459 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1459 EcoGene EG11496 http://www.ecogene.org/geneInfo.php?eg_id=EG11496 EnsemblBacteria BAA77905 http://www.ensemblgenomes.org/id/BAA77905 EnsemblBacteria BAA77905 http://www.ensemblgenomes.org/id/BAA77905 EnsemblBacteria BAA77905 http://www.ensemblgenomes.org/id/BAA77905 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016149 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016149 GO_function GO:0043022 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043022 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008135 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008135 Gene3D 3.30.160.20 http://www.cathdb.info/version/latest/superfamily/3.30.160.20 HOGENOM HOG000117078 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117078&db=HOGENOM6 InParanoid P28369 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P28369 IntAct P28369 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P28369* InterPro IPR000352 http://www.ebi.ac.uk/interpro/entry/IPR000352 InterPro IPR014720 http://www.ebi.ac.uk/interpro/entry/IPR014720 InterPro IPR017509 http://www.ebi.ac.uk/interpro/entry/IPR017509 KEGG_Gene ecj:JW0226 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0226 OMA HARKNWF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HARKNWF PROSITE PS00745 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00745 PSORT swissprot:RFH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RFH_ECOLI PSORT-B swissprot:RFH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RFH_ECOLI PSORT2 swissprot:RFH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RFH_ECOLI Pfam PF00472 http://pfam.xfam.org/family/PF00472 Phobius swissprot:RFH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RFH_ECOLI PhylomeDB P28369 http://phylomedb.org/?seqid=P28369 ProteinModelPortal P28369 http://www.proteinmodelportal.org/query/uniprot/P28369 PubMed 1408743 http://www.ncbi.nlm.nih.gov/pubmed/1408743 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1695895 http://www.ncbi.nlm.nih.gov/pubmed/1695895 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SMR P28369 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P28369 STRING 316407.85674391 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85674391&targetmode=cogs TIGRFAMs TIGR03072 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03072 UniProtKB RFH_ECOLI http://www.uniprot.org/uniprot/RFH_ECOLI UniProtKB-AC P28369 http://www.uniprot.org/uniprot/P28369 charge swissprot:RFH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RFH_ECOLI eggNOG COG1186 http://eggnogapi.embl.de/nog_data/html/tree/COG1186 eggNOG ENOG4108S2Y http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108S2Y epestfind swissprot:RFH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RFH_ECOLI garnier swissprot:RFH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RFH_ECOLI helixturnhelix swissprot:RFH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RFH_ECOLI hmoment swissprot:RFH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RFH_ECOLI iep swissprot:RFH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RFH_ECOLI inforesidue swissprot:RFH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RFH_ECOLI octanol swissprot:RFH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RFH_ECOLI pepcoil swissprot:RFH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RFH_ECOLI pepdigest swissprot:RFH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RFH_ECOLI pepinfo swissprot:RFH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RFH_ECOLI pepnet swissprot:RFH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RFH_ECOLI pepstats swissprot:RFH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RFH_ECOLI pepwheel swissprot:RFH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RFH_ECOLI pepwindow swissprot:RFH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RFH_ECOLI sigcleave swissprot:RFH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RFH_ECOLI ## Database ID URL or Descriptions # AltName Fifty-four homolog {ECO:0000255|HAMAP-Rule MF_00306} # AltName SRP54_ECOLI p48 # BioGrid 4262086 262 # DISRUPTION PHENOTYPE SRP54_ECOLI Essential; deletion experiments lead to loss of inner membrane protein targeting. Also leads to reduced targeting of lipoproteins Lpp and BRP. {ECO 0000269|PubMed 11741850, ECO 0000269|PubMed 15140892}. # DOMAIN SRP54_ECOLI Composed of three domains the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC. {ECO 0000255|HAMAP- Rule MF_00306, ECO 0000269|PubMed 10678824, ECO 0000269|PubMed 12702815}. # ENZYME REGULATION Conformation of the Ffh-FtsY complex and regulation of its GTPase activity are modulated by the 4.5S RNA. Formation of the FfH-FtsY complex leads to a mutual stimulation of both GTPases. {ECO:0000269|PubMed 11735405}. # EcoGene EG10300 ffh # FUNCTION SRP54_ECOLI Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. {ECO 0000255|HAMAP-Rule MF_00306, ECO 0000269|PubMed 11735405, ECO 0000269|PubMed 11741850, ECO 0000269|PubMed 1279430, ECO 0000269|PubMed 1331806, ECO 0000269|PubMed 15140892, ECO 0000269|PubMed 2171778, ECO 0000269|PubMed 9305630}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0030529 intracellular ribonucleoprotein complex; IDA:EcoliWiki. # GO_component GO:0048500 signal recognition particle; IMP:EcoliWiki. # GO_function GO:0003924 GTPase activity; IMP:EcoCyc. # GO_function GO:0005525 GTP binding; IDA:EcoliWiki. # GO_function GO:0008312 7S RNA binding; IEA:InterPro. # GO_process GO:0006612 protein targeting to membrane; IMP:EcoliWiki. # GO_process GO:0006614 SRP-dependent cotranslational protein targeting to membrane; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0003924 GTPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006605 protein targeting # GOslim_process GO:0061024 membrane organization # Gene3D 1.10.260.30 -; 1. # Gene3D 3.40.50.300 -; 1. # HAMAP MF_00306 SRP54 # IntAct P0AGD7 19 # InterPro IPR000897 SRP54_GTPase_dom # InterPro IPR003593 AAA+_ATPase # InterPro IPR004125 Signal_recog_particle_SRP54_M # InterPro IPR004780 SRP_Ffh # InterPro IPR013822 Signal_recog_particl_SRP54_hlx # InterPro IPR022941 SRP54 # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02044 M00335 Sec (secretion) system # KEGG_Brite ko02044 Secretion system # KEGG_Pathway ko03060 Protein export # KEGG_Pathway ko03070 Bacterial secretion system # Organism SRP54_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11564:SF7 PTHR11564:SF7 # PATRIC 32120619 VBIEscCol129921_2708 # PDB 1DUL X-ray; 1.80 A; A=329-430 # PDB 1HQ1 X-ray; 1.52 A; A=328-432 # PDB 2J28 EM; 8.00 A; 9=2-431 # PDB 2PXB X-ray; 2.00 A; A=329-430 # PDB 2PXD X-ray; 2.00 A; A=329-430 # PDB 2PXE X-ray; 2.00 A; A=329-430 # PDB 2PXF X-ray; 2.00 A; A=329-430 # PDB 2PXK X-ray; 2.00 A; A=329-430 # PDB 2PXL X-ray; 2.50 A; A=329-430 # PDB 2PXP X-ray; 2.50 A; A=329-430 # PDB 2PXQ X-ray; 2.50 A; A=329-430 # PDB 2PXT X-ray; 2.50 A; A=329-430 # PDB 2PXU X-ray; 2.50 A; A=329-430 # PDB 2PXV X-ray; 2.00 A; A=329-430 # PDB 2XKV EM; 13.50 A; C=329-430 # PDB 2XXA X-ray; 3.94 A; A/C=1-433 # PDB 3LQX X-ray; 1.93 A; A=329-428 # PDB 4C7O X-ray; 2.60 A; A/C=1-298 # PDB 5AKA EM; 5.70 A; 5=328-436 # PDB 5GAD EM; 3.70 A; i=4-434 # PDB 5GAF EM; 4.30 A; i=1-434 # PDB 5GAG EM; 3.80 A; i=4-434 # PDB 5GAH EM; 3.80 A; i=1-434 # PIR E65039 E65039 # PROSITE PS00300 SRP54 # Pfam PF00448 SRP54 # Pfam PF02881 SRP54_N # Pfam PF02978 SRP_SPB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Signal recognition particle protein {ECO:0000255|HAMAP-Rule MF_00306} # RefSeq NP_417101 NC_000913.3 # RefSeq WP_000460035 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA25957.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the GTP-binding SRP family. SRP54 subfamily. {ECO:0000255|HAMAP-Rule MF_00306}. # SMART SM00382 AAA # SMART SM00962 SRP54 # SMART SM00963 SRP54_N # SUBCELLULAR LOCATION SRP54_ECOLI Cytoplasm. Note=The SRP-RNC complex is targeted to the cytoplasmic membrane. # SUBUNIT SRP54_ECOLI Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule. Metal ions are essential for the formation and stability of the SRP complex. Interacts with the ribosomes, via ribosomal protein L23. Interacts with FtsY. {ECO 0000255|HAMAP-Rule MF_00306, ECO 0000269|PubMed 10678824, ECO 0000269|PubMed 12269812, ECO 0000269|PubMed 12702815, ECO 0000269|PubMed 12756233, ECO 0000269|PubMed 1279430, ECO 0000269|PubMed 1331806, ECO 0000269|PubMed 9305630}. # SUPFAM SSF47446 SSF47446 # SUPFAM SSF52540 SSF52540 # TCDB 3.A.5.1 the general secretory pathway (sec) family # TIGRFAMs TIGR00959 ffh # eggNOG COG0541 LUCA # eggNOG ENOG4105CB9 Bacteria BLAST swissprot:SRP54_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SRP54_ECOLI BioCyc ECOL316407:JW5414-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5414-MONOMER BioCyc EcoCyc:EG10300-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10300-MONOMER COG COG0541 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0541 DIP DIP-31865N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31865N DOI 10.1016/0014-5793(96)01019-8 http://dx.doi.org/10.1016/0014-5793(96)01019-8 DOI 10.1016/0092-8674(90)90454-M http://dx.doi.org/10.1016/0092-8674(90)90454-M DOI 10.1016/j.bbamem.2010.07.025 http://dx.doi.org/10.1016/j.bbamem.2010.07.025 DOI 10.1016/j.str.2007.06.003 http://dx.doi.org/10.1016/j.str.2007.06.003 DOI 10.1021/bi011639y http://dx.doi.org/10.1021/bi011639y DOI 10.1021/bi026163c http://dx.doi.org/10.1021/bi026163c DOI 10.1038/359741a0 http://dx.doi.org/10.1038/359741a0 DOI 10.1038/359744a0 http://dx.doi.org/10.1038/359744a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature05326 http://dx.doi.org/10.1038/nature05326 DOI 10.1038/nsmb.1952 http://dx.doi.org/10.1038/nsmb.1952 DOI 10.1073/pnas.0402231101 http://dx.doi.org/10.1073/pnas.0402231101 DOI 10.1074/jbc.M403229200 http://dx.doi.org/10.1074/jbc.M403229200 DOI 10.1083/jcb.200302130 http://dx.doi.org/10.1083/jcb.200302130 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/emboj/16.16.4880 http://dx.doi.org/10.1093/emboj/16.16.4880 DOI 10.1126/science.1196473 http://dx.doi.org/10.1126/science.1196473 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1126/science.287.5456.1232 http://dx.doi.org/10.1126/science.287.5456.1232 DOI 10.1128/JB.184.1.111-118.2002 http://dx.doi.org/10.1128/JB.184.1.111-118.2002 DOI 10.1261/rna.2196403 http://dx.doi.org/10.1261/rna.2196403 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X01818 http://www.ebi.ac.uk/ena/data/view/X01818 EchoBASE EB0296 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0296 EcoGene EG10300 http://www.ecogene.org/geneInfo.php?eg_id=EG10300 EnsemblBacteria AAC75659 http://www.ensemblgenomes.org/id/AAC75659 EnsemblBacteria AAC75659 http://www.ensemblgenomes.org/id/AAC75659 EnsemblBacteria BAA16495 http://www.ensemblgenomes.org/id/BAA16495 EnsemblBacteria BAA16495 http://www.ensemblgenomes.org/id/BAA16495 EnsemblBacteria BAA16495 http://www.ensemblgenomes.org/id/BAA16495 EnsemblBacteria b2610 http://www.ensemblgenomes.org/id/b2610 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0030529 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030529 GO_component GO:0048500 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048500 GO_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GO_function GO:0005525 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005525 GO_function GO:0008312 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008312 GO_process GO:0006612 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006612 GO_process GO:0006614 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006614 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006605 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006605 GOslim_process GO:0061024 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024 Gene3D 1.10.260.30 http://www.cathdb.info/version/latest/superfamily/1.10.260.30 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947102 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947102 HAMAP MF_00306 http://hamap.expasy.org/unirule/MF_00306 HOGENOM HOG000036164 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000036164&db=HOGENOM6 InParanoid P0AGD7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGD7 IntAct P0AGD7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AGD7* InterPro IPR000897 http://www.ebi.ac.uk/interpro/entry/IPR000897 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR004125 http://www.ebi.ac.uk/interpro/entry/IPR004125 InterPro IPR004780 http://www.ebi.ac.uk/interpro/entry/IPR004780 InterPro IPR013822 http://www.ebi.ac.uk/interpro/entry/IPR013822 InterPro IPR022941 http://www.ebi.ac.uk/interpro/entry/IPR022941 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW5414 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5414 KEGG_Gene eco:b2610 http://www.genome.jp/dbget-bin/www_bget?eco:b2610 KEGG_Orthology KO:K03106 http://www.genome.jp/dbget-bin/www_bget?KO:K03106 KEGG_Pathway ko03060 http://www.genome.jp/kegg-bin/show_pathway?ko03060 KEGG_Pathway ko03070 http://www.genome.jp/kegg-bin/show_pathway?ko03070 MINT MINT-1218614 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1218614 OMA MLPGMGQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MLPGMGQ PANTHER PTHR11564:SF7 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11564:SF7 PDB 1DUL http://www.ebi.ac.uk/pdbe-srv/view/entry/1DUL PDB 1HQ1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1HQ1 PDB 2J28 http://www.ebi.ac.uk/pdbe-srv/view/entry/2J28 PDB 2PXB http://www.ebi.ac.uk/pdbe-srv/view/entry/2PXB PDB 2PXD http://www.ebi.ac.uk/pdbe-srv/view/entry/2PXD PDB 2PXE http://www.ebi.ac.uk/pdbe-srv/view/entry/2PXE PDB 2PXF http://www.ebi.ac.uk/pdbe-srv/view/entry/2PXF PDB 2PXK http://www.ebi.ac.uk/pdbe-srv/view/entry/2PXK PDB 2PXL http://www.ebi.ac.uk/pdbe-srv/view/entry/2PXL PDB 2PXP http://www.ebi.ac.uk/pdbe-srv/view/entry/2PXP PDB 2PXQ http://www.ebi.ac.uk/pdbe-srv/view/entry/2PXQ PDB 2PXT http://www.ebi.ac.uk/pdbe-srv/view/entry/2PXT PDB 2PXU http://www.ebi.ac.uk/pdbe-srv/view/entry/2PXU PDB 2PXV http://www.ebi.ac.uk/pdbe-srv/view/entry/2PXV PDB 2XKV http://www.ebi.ac.uk/pdbe-srv/view/entry/2XKV PDB 2XXA http://www.ebi.ac.uk/pdbe-srv/view/entry/2XXA PDB 3LQX http://www.ebi.ac.uk/pdbe-srv/view/entry/3LQX PDB 4C7O http://www.ebi.ac.uk/pdbe-srv/view/entry/4C7O PDB 5AKA http://www.ebi.ac.uk/pdbe-srv/view/entry/5AKA PDB 5GAD http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAD PDB 5GAF http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAF PDB 5GAG http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAG PDB 5GAH http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAH PDBsum 1DUL http://www.ebi.ac.uk/pdbsum/1DUL PDBsum 1HQ1 http://www.ebi.ac.uk/pdbsum/1HQ1 PDBsum 2J28 http://www.ebi.ac.uk/pdbsum/2J28 PDBsum 2PXB http://www.ebi.ac.uk/pdbsum/2PXB PDBsum 2PXD http://www.ebi.ac.uk/pdbsum/2PXD PDBsum 2PXE http://www.ebi.ac.uk/pdbsum/2PXE PDBsum 2PXF http://www.ebi.ac.uk/pdbsum/2PXF PDBsum 2PXK http://www.ebi.ac.uk/pdbsum/2PXK PDBsum 2PXL http://www.ebi.ac.uk/pdbsum/2PXL PDBsum 2PXP http://www.ebi.ac.uk/pdbsum/2PXP PDBsum 2PXQ http://www.ebi.ac.uk/pdbsum/2PXQ PDBsum 2PXT http://www.ebi.ac.uk/pdbsum/2PXT PDBsum 2PXU http://www.ebi.ac.uk/pdbsum/2PXU PDBsum 2PXV http://www.ebi.ac.uk/pdbsum/2PXV PDBsum 2XKV http://www.ebi.ac.uk/pdbsum/2XKV PDBsum 2XXA http://www.ebi.ac.uk/pdbsum/2XXA PDBsum 3LQX http://www.ebi.ac.uk/pdbsum/3LQX PDBsum 4C7O http://www.ebi.ac.uk/pdbsum/4C7O PDBsum 5AKA http://www.ebi.ac.uk/pdbsum/5AKA PDBsum 5GAD http://www.ebi.ac.uk/pdbsum/5GAD PDBsum 5GAF http://www.ebi.ac.uk/pdbsum/5GAF PDBsum 5GAG http://www.ebi.ac.uk/pdbsum/5GAG PDBsum 5GAH http://www.ebi.ac.uk/pdbsum/5GAH PROSITE PS00300 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00300 PSORT swissprot:SRP54_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SRP54_ECOLI PSORT-B swissprot:SRP54_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SRP54_ECOLI PSORT2 swissprot:SRP54_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SRP54_ECOLI Pfam PF00448 http://pfam.xfam.org/family/PF00448 Pfam PF02881 http://pfam.xfam.org/family/PF02881 Pfam PF02978 http://pfam.xfam.org/family/PF02978 Phobius swissprot:SRP54_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SRP54_ECOLI PhylomeDB P0AGD7 http://phylomedb.org/?seqid=P0AGD7 ProteinModelPortal P0AGD7 http://www.proteinmodelportal.org/query/uniprot/P0AGD7 PubMed 10678824 http://www.ncbi.nlm.nih.gov/pubmed/10678824 PubMed 11735405 http://www.ncbi.nlm.nih.gov/pubmed/11735405 PubMed 11741850 http://www.ncbi.nlm.nih.gov/pubmed/11741850 PubMed 12269812 http://www.ncbi.nlm.nih.gov/pubmed/12269812 PubMed 12702815 http://www.ncbi.nlm.nih.gov/pubmed/12702815 PubMed 12756233 http://www.ncbi.nlm.nih.gov/pubmed/12756233 PubMed 1279430 http://www.ncbi.nlm.nih.gov/pubmed/1279430 PubMed 1331806 http://www.ncbi.nlm.nih.gov/pubmed/1331806 PubMed 15140892 http://www.ncbi.nlm.nih.gov/pubmed/15140892 PubMed 15148364 http://www.ncbi.nlm.nih.gov/pubmed/15148364 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17086193 http://www.ncbi.nlm.nih.gov/pubmed/17086193 PubMed 17637337 http://www.ncbi.nlm.nih.gov/pubmed/17637337 PubMed 20682283 http://www.ncbi.nlm.nih.gov/pubmed/20682283 PubMed 21151118 http://www.ncbi.nlm.nih.gov/pubmed/21151118 PubMed 21330537 http://www.ncbi.nlm.nih.gov/pubmed/21330537 PubMed 2171778 http://www.ncbi.nlm.nih.gov/pubmed/2171778 PubMed 6357787 http://www.ncbi.nlm.nih.gov/pubmed/6357787 PubMed 8898086 http://www.ncbi.nlm.nih.gov/pubmed/8898086 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9305630 http://www.ncbi.nlm.nih.gov/pubmed/9305630 RefSeq NP_417101 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417101 RefSeq WP_000460035 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000460035 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMART SM00962 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00962 SMART SM00963 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00963 SMR P0AGD7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AGD7 STRING 511145.b2610 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2610&targetmode=cogs STRING COG0541 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0541&targetmode=cogs SUPFAM SSF47446 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47446 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.5.1 http://www.tcdb.org/search/result.php?tc=3.A.5.1 TIGRFAMs TIGR00959 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00959 UniProtKB SRP54_ECOLI http://www.uniprot.org/uniprot/SRP54_ECOLI UniProtKB-AC P0AGD7 http://www.uniprot.org/uniprot/P0AGD7 charge swissprot:SRP54_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SRP54_ECOLI eggNOG COG0541 http://eggnogapi.embl.de/nog_data/html/tree/COG0541 eggNOG ENOG4105CB9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CB9 epestfind swissprot:SRP54_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SRP54_ECOLI garnier swissprot:SRP54_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SRP54_ECOLI helixturnhelix swissprot:SRP54_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SRP54_ECOLI hmoment swissprot:SRP54_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SRP54_ECOLI iep swissprot:SRP54_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SRP54_ECOLI inforesidue swissprot:SRP54_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SRP54_ECOLI octanol swissprot:SRP54_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SRP54_ECOLI pepcoil swissprot:SRP54_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SRP54_ECOLI pepdigest swissprot:SRP54_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SRP54_ECOLI pepinfo swissprot:SRP54_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SRP54_ECOLI pepnet swissprot:SRP54_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SRP54_ECOLI pepstats swissprot:SRP54_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SRP54_ECOLI pepwheel swissprot:SRP54_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SRP54_ECOLI pepwindow swissprot:SRP54_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SRP54_ECOLI sigcleave swissprot:SRP54_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SRP54_ECOLI ## Database ID URL or Descriptions # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_function GO:0008170 N-methyltransferase activity; IEA:InterPro. # GO_process GO:0006306 DNA methylation; IEA:InterPro. # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0006259 DNA metabolic process # Gene3D 3.40.50.150 -; 1. # InterPro IPR001091 RM_Methylase # InterPro IPR002052 DNA_methylase_N6_adenine_CS # InterPro IPR002941 DNA_methylase_N4/N6 # InterPro IPR029063 SAM-dependent_MTases # Organism YUBD_ECOLI Escherichia coli (strain K12) # PRINTS PR00508 S21N4MTFRASE # PROSITE PS00092 N6_MTASE # Pfam PF01555 N6_N4_Mtase # REBASE 8255 M.EcoCR63FORFAP # RecName YUBD_ECOLI Putative methylase YubD # RefSeq NP_061431 NC_002483.1 # RefSeq WP_000085939 NZ_CP014273.1 # SIMILARITY Belongs to the N(4)/N(6)-methyltransferase family. {ECO 0000305}. # SUPFAM SSF53335 SSF53335 BLAST swissprot:YUBD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YUBD_ECOLI DOI 10.1006/plas.1999.1390 http://dx.doi.org/10.1006/plas.1999.1390 EC_number EC:2.1.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.- EMBL AF106329 http://www.ebi.ac.uk/ena/data/view/AF106329 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 ENZYME 2.1.1.- http://enzyme.expasy.org/EC/2.1.1.- G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0008170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008170 GO_process GO:0006306 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006306 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 GeneID 1263496 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263496 IntEnz 2.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1 InterPro IPR001091 http://www.ebi.ac.uk/interpro/entry/IPR001091 InterPro IPR002052 http://www.ebi.ac.uk/interpro/entry/IPR002052 InterPro IPR002941 http://www.ebi.ac.uk/interpro/entry/IPR002941 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 OMA VRVMATF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VRVMATF PRINTS PR00508 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00508 PROSITE PS00092 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00092 PSORT swissprot:YUBD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YUBD_ECOLI PSORT-B swissprot:YUBD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YUBD_ECOLI PSORT2 swissprot:YUBD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YUBD_ECOLI Pfam PF01555 http://pfam.xfam.org/family/PF01555 Phobius swissprot:YUBD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YUBD_ECOLI PhylomeDB Q9S4X2 http://phylomedb.org/?seqid=Q9S4X2 ProteinModelPortal Q9S4X2 http://www.proteinmodelportal.org/query/uniprot/Q9S4X2 PubMed 10366527 http://www.ncbi.nlm.nih.gov/pubmed/10366527 REBASE 8255 http://rebase.neb.com/rebase/enz/8255.html RefSeq NP_061431 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061431 RefSeq WP_000085939 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000085939 SMR Q9S4X2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9S4X2 SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 UniProtKB YUBD_ECOLI http://www.uniprot.org/uniprot/YUBD_ECOLI UniProtKB-AC Q9S4X2 http://www.uniprot.org/uniprot/Q9S4X2 charge swissprot:YUBD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YUBD_ECOLI epestfind swissprot:YUBD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YUBD_ECOLI garnier swissprot:YUBD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YUBD_ECOLI helixturnhelix swissprot:YUBD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YUBD_ECOLI hmoment swissprot:YUBD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YUBD_ECOLI iep swissprot:YUBD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YUBD_ECOLI inforesidue swissprot:YUBD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YUBD_ECOLI octanol swissprot:YUBD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YUBD_ECOLI pepcoil swissprot:YUBD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YUBD_ECOLI pepdigest swissprot:YUBD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YUBD_ECOLI pepinfo swissprot:YUBD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YUBD_ECOLI pepnet swissprot:YUBD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YUBD_ECOLI pepstats swissprot:YUBD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YUBD_ECOLI pepwheel swissprot:YUBD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YUBD_ECOLI pepwindow swissprot:YUBD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YUBD_ECOLI sigcleave swissprot:YUBD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YUBD_ECOLI ## Database ID URL or Descriptions # BioGrid 4261570 11 # EcoGene EG10323 fliM # FUNCTION FLIM_ECOLI FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0009425 bacterial-type flagellum basal body; IEA:UniProtKB-SubCell. # GO_function GO:0003774 motor activity; IEA:InterPro. # GO_process GO:0050918 positive chemotaxis; IBA:GO_Central. # GO_process GO:0071973 bacterial-type flagellum-dependent cell motility; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0040011 locomotion # GOslim_process GO:0048870 cell motility # INTERACTION FLIM_ECOLI P0ABZ1 fliG; NbExp=16; IntAct=EBI-560439, EBI-1126524; P15070 fliN; NbExp=7; IntAct=EBI-560439, EBI-2011987; P76010 ycgR; NbExp=3; IntAct=EBI-560439, EBI-554507; # IntAct P06974 18 # InterPro IPR001543 SpoA # InterPro IPR001689 Flag_FliM # InterPro IPR028976 CheC-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Pathway ko02030 Bacterial chemotaxis # KEGG_Pathway ko02040 Flagellar assembly # Organism FLIM_ECOLI Escherichia coli (strain K12) # PATRIC 32119219 VBIEscCol129921_2024 # PDB 1F4V X-ray; 2.22 A; D/E/F=1-16 # PDB 1U8T X-ray; 1.50 A; E/F=1-16 # PDB 2B1J X-ray; 2.40 A; C/D=1-16 # PIR B29842 XMECF2 # PIRSF PIRSF002888 FliM # PRINTS PR00955 FLGMOTORFLIM # Pfam PF01052 FliMN_C # Pfam PF02154 FliM # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FLIM_ECOLI Flagellar motor switch protein FliM # RefSeq NP_416455 NC_000913.3 # RefSeq WP_001350520 NZ_LN832404.1 # SIMILARITY Belongs to the FliM family. {ECO 0000305}. # SUBCELLULAR LOCATION FLIM_ECOLI Cell inner membrane; Peripheral membrane protein. Bacterial flagellum basal body. # SUBUNIT Interacts with flagellar brake protein YcgR. {ECO:0000269|PubMed 20346719}. # SUPFAM SSF101801 SSF101801 # SUPFAM SSF103039 SSF103039 # TIGRFAMs TIGR01397 fliM_switch # eggNOG COG1868 LUCA # eggNOG ENOG4105D24 Bacteria BLAST swissprot:FLIM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLIM_ECOLI BioCyc ECOL316407:JW1929-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1929-MONOMER BioCyc EcoCyc:FLIM-FLAGELLAR-C-RING-SWITCH http://biocyc.org/getid?id=EcoCyc:FLIM-FLAGELLAR-C-RING-SWITCH COG COG1868 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1868 DIP DIP-1100N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-1100N DOI 10.1016/S1937-6448(08)01402-0 http://dx.doi.org/10.1016/S1937-6448(08)01402-0 DOI 10.1016/j.molcel.2010.03.001 http://dx.doi.org/10.1016/j.molcel.2010.03.001 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M12784 http://www.ebi.ac.uk/ena/data/view/M12784 EMBL M26294 http://www.ebi.ac.uk/ena/data/view/M26294 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0319 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0319 EcoGene EG10323 http://www.ecogene.org/geneInfo.php?eg_id=EG10323 EnsemblBacteria AAC75012 http://www.ensemblgenomes.org/id/AAC75012 EnsemblBacteria AAC75012 http://www.ensemblgenomes.org/id/AAC75012 EnsemblBacteria BAA15770 http://www.ensemblgenomes.org/id/BAA15770 EnsemblBacteria BAA15770 http://www.ensemblgenomes.org/id/BAA15770 EnsemblBacteria BAA15770 http://www.ensemblgenomes.org/id/BAA15770 EnsemblBacteria b1945 http://www.ensemblgenomes.org/id/b1945 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0009425 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009425 GO_function GO:0003774 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003774 GO_process GO:0050918 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050918 GO_process GO:0071973 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071973 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0040011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 GeneID 946442 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946442 HOGENOM HOG000253580 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000253580&db=HOGENOM6 InParanoid P06974 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P06974 IntAct P06974 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P06974* InterPro IPR001543 http://www.ebi.ac.uk/interpro/entry/IPR001543 InterPro IPR001689 http://www.ebi.ac.uk/interpro/entry/IPR001689 InterPro IPR028976 http://www.ebi.ac.uk/interpro/entry/IPR028976 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW1929 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1929 KEGG_Gene eco:b1945 http://www.genome.jp/dbget-bin/www_bget?eco:b1945 KEGG_Orthology KO:K02416 http://www.genome.jp/dbget-bin/www_bget?KO:K02416 KEGG_Pathway ko02030 http://www.genome.jp/kegg-bin/show_pathway?ko02030 KEGG_Pathway ko02040 http://www.genome.jp/kegg-bin/show_pathway?ko02040 MINT MINT-1301311 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1301311 OMA NPQFTQI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NPQFTQI PDB 1F4V http://www.ebi.ac.uk/pdbe-srv/view/entry/1F4V PDB 1U8T http://www.ebi.ac.uk/pdbe-srv/view/entry/1U8T PDB 2B1J http://www.ebi.ac.uk/pdbe-srv/view/entry/2B1J PDBsum 1F4V http://www.ebi.ac.uk/pdbsum/1F4V PDBsum 1U8T http://www.ebi.ac.uk/pdbsum/1U8T PDBsum 2B1J http://www.ebi.ac.uk/pdbsum/2B1J PRINTS PR00955 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00955 PSORT swissprot:FLIM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLIM_ECOLI PSORT-B swissprot:FLIM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLIM_ECOLI PSORT2 swissprot:FLIM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLIM_ECOLI Pfam PF01052 http://pfam.xfam.org/family/PF01052 Pfam PF02154 http://pfam.xfam.org/family/PF02154 Phobius swissprot:FLIM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLIM_ECOLI PhylomeDB P06974 http://phylomedb.org/?seqid=P06974 ProteinModelPortal P06974 http://www.proteinmodelportal.org/query/uniprot/P06974 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19081534 http://www.ncbi.nlm.nih.gov/pubmed/19081534 PubMed 20346719 http://www.ncbi.nlm.nih.gov/pubmed/20346719 PubMed 2651416 http://www.ncbi.nlm.nih.gov/pubmed/2651416 PubMed 3519573 http://www.ncbi.nlm.nih.gov/pubmed/3519573 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416455 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416455 RefSeq WP_001350520 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001350520 SMR P06974 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P06974 STRING 511145.b1945 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1945&targetmode=cogs STRING COG1868 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1868&targetmode=cogs SUPFAM SSF101801 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF101801 SUPFAM SSF103039 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103039 TIGRFAMs TIGR01397 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01397 UniProtKB FLIM_ECOLI http://www.uniprot.org/uniprot/FLIM_ECOLI UniProtKB-AC P06974 http://www.uniprot.org/uniprot/P06974 charge swissprot:FLIM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLIM_ECOLI eggNOG COG1868 http://eggnogapi.embl.de/nog_data/html/tree/COG1868 eggNOG ENOG4105D24 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D24 epestfind swissprot:FLIM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLIM_ECOLI garnier swissprot:FLIM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLIM_ECOLI helixturnhelix swissprot:FLIM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLIM_ECOLI hmoment swissprot:FLIM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLIM_ECOLI iep swissprot:FLIM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLIM_ECOLI inforesidue swissprot:FLIM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLIM_ECOLI octanol swissprot:FLIM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLIM_ECOLI pepcoil swissprot:FLIM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLIM_ECOLI pepdigest swissprot:FLIM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLIM_ECOLI pepinfo swissprot:FLIM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLIM_ECOLI pepnet swissprot:FLIM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLIM_ECOLI pepstats swissprot:FLIM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLIM_ECOLI pepwheel swissprot:FLIM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLIM_ECOLI pepwindow swissprot:FLIM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLIM_ECOLI sigcleave swissprot:FLIM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLIM_ECOLI ## Database ID URL or Descriptions # BioGrid 4262400 5 # EcoGene EG10253 ebgC # FUNCTION EBGC_ECOLI Required for full activity of the EbgA enzyme. Exact function not known. # Gene3D 2.60.120.370 -; 1. # IntAct P0AC73 6 # InterPro IPR004375 YhcH/YjgK/YiaL # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko00052 Galactose metabolism # KEGG_Pathway ko00511 Other glycan degradation # Organism EBGC_ECOLI Escherichia coli (strain K12) # PATRIC 32121570 VBIEscCol129921_3171 # PIR B65096 B65096 # Pfam PF04074 DUF386 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EBGC_ECOLI Evolved beta-galactosidase subunit beta # RefSeq NP_417548 NC_000913.3 # RefSeq WP_001219954 NZ_LN832404.1 # SUBUNIT Heterooctamer of 4 alpha and 4 beta subunits. {ECO:0000269|PubMed 1540130}. # eggNOG COG2731 LUCA # eggNOG ENOG4105FK9 Bacteria BLAST swissprot:EBGC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EBGC_ECOLI BioCyc ECOL316407:JW3048-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3048-MONOMER BioCyc EcoCyc:EG10253-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10253-MONOMER COG COG2731 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2731 DIP DIP-2894N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-2894N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2820155 http://dx.doi.org/10.1042/bj2820155 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M64441 http://www.ebi.ac.uk/ena/data/view/M64441 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X52031 http://www.ebi.ac.uk/ena/data/view/X52031 EchoBASE EB0249 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0249 EcoGene EG10253 http://www.ecogene.org/geneInfo.php?eg_id=EG10253 EnsemblBacteria AAC76112 http://www.ensemblgenomes.org/id/AAC76112 EnsemblBacteria AAC76112 http://www.ensemblgenomes.org/id/AAC76112 EnsemblBacteria BAE77127 http://www.ensemblgenomes.org/id/BAE77127 EnsemblBacteria BAE77127 http://www.ensemblgenomes.org/id/BAE77127 EnsemblBacteria BAE77127 http://www.ensemblgenomes.org/id/BAE77127 EnsemblBacteria b3077 http://www.ensemblgenomes.org/id/b3077 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 2.60.120.370 http://www.cathdb.info/version/latest/superfamily/2.60.120.370 GeneID 947581 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947581 HOGENOM HOG000125115 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125115&db=HOGENOM6 IntAct P0AC73 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AC73* InterPro IPR004375 http://www.ebi.ac.uk/interpro/entry/IPR004375 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW3048 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3048 KEGG_Gene eco:b3077 http://www.genome.jp/dbget-bin/www_bget?eco:b3077 KEGG_Orthology KO:K12112 http://www.genome.jp/dbget-bin/www_bget?KO:K12112 KEGG_Pathway ko00052 http://www.genome.jp/kegg-bin/show_pathway?ko00052 KEGG_Pathway ko00511 http://www.genome.jp/kegg-bin/show_pathway?ko00511 KEGG_Reaction rn:R01678 http://www.genome.jp/dbget-bin/www_bget?rn:R01678 OMA KWNRCVE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KWNRCVE PSORT swissprot:EBGC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EBGC_ECOLI PSORT-B swissprot:EBGC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EBGC_ECOLI PSORT2 swissprot:EBGC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EBGC_ECOLI Pfam PF04074 http://pfam.xfam.org/family/PF04074 Phobius swissprot:EBGC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EBGC_ECOLI ProteinModelPortal P0AC73 http://www.proteinmodelportal.org/query/uniprot/P0AC73 PubMed 1540130 http://www.ncbi.nlm.nih.gov/pubmed/1540130 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2515108 http://www.ncbi.nlm.nih.gov/pubmed/2515108 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417548 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417548 RefSeq WP_001219954 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001219954 SMR P0AC73 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AC73 STRING 511145.b3077 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3077&targetmode=cogs STRING COG2731 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2731&targetmode=cogs UniProtKB EBGC_ECOLI http://www.uniprot.org/uniprot/EBGC_ECOLI UniProtKB-AC P0AC73 http://www.uniprot.org/uniprot/P0AC73 charge swissprot:EBGC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EBGC_ECOLI eggNOG COG2731 http://eggnogapi.embl.de/nog_data/html/tree/COG2731 eggNOG ENOG4105FK9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FK9 epestfind swissprot:EBGC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EBGC_ECOLI garnier swissprot:EBGC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EBGC_ECOLI helixturnhelix swissprot:EBGC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EBGC_ECOLI hmoment swissprot:EBGC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EBGC_ECOLI iep swissprot:EBGC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EBGC_ECOLI inforesidue swissprot:EBGC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EBGC_ECOLI octanol swissprot:EBGC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EBGC_ECOLI pepcoil swissprot:EBGC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EBGC_ECOLI pepdigest swissprot:EBGC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EBGC_ECOLI pepinfo swissprot:EBGC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EBGC_ECOLI pepnet swissprot:EBGC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EBGC_ECOLI pepstats swissprot:EBGC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EBGC_ECOLI pepwheel swissprot:EBGC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EBGC_ECOLI pepwindow swissprot:EBGC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EBGC_ECOLI sigcleave swissprot:EBGC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EBGC_ECOLI ## Database ID URL or Descriptions # BioGrid 4262814 11 # EcoGene EG14279 yaiY # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR020513 Uncharacterised_IM_YaiY # Organism YAIY_ECOLI Escherichia coli (strain K12) # PATRIC 32115899 VBIEscCol129921_0391 # PIR C64766 C64766 # Pfam PF10954 DUF2755 # ProDom PD068630 Inner_membrane_protein_YaiY # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAIY_ECOLI Inner membrane protein YaiY # RefSeq NP_414913 NC_000913.3 # RefSeq WP_000763151 NZ_LN832404.1 # SUBCELLULAR LOCATION YAIY_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG ENOG4105FR5 Bacteria # eggNOG ENOG4111PM6 LUCA BLAST swissprot:YAIY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAIY_ECOLI BioCyc ECOL316407:JW0370-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0370-MONOMER BioCyc EcoCyc:G6228-MONOMER http://biocyc.org/getid?id=EcoCyc:G6228-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB4027 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4027 EcoGene EG14279 http://www.ecogene.org/geneInfo.php?eg_id=EG14279 EnsemblBacteria AAC73482 http://www.ensemblgenomes.org/id/AAC73482 EnsemblBacteria AAC73482 http://www.ensemblgenomes.org/id/AAC73482 EnsemblBacteria BAE76160 http://www.ensemblgenomes.org/id/BAE76160 EnsemblBacteria BAE76160 http://www.ensemblgenomes.org/id/BAE76160 EnsemblBacteria BAE76160 http://www.ensemblgenomes.org/id/BAE76160 EnsemblBacteria b0379 http://www.ensemblgenomes.org/id/b0379 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 945223 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945223 HOGENOM HOG000117479 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117479&db=HOGENOM6 InParanoid P0AAP7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAP7 InterPro IPR020513 http://www.ebi.ac.uk/interpro/entry/IPR020513 KEGG_Gene ecj:JW0370 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0370 KEGG_Gene eco:b0379 http://www.genome.jp/dbget-bin/www_bget?eco:b0379 OMA CFWAGSQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CFWAGSQ PSORT swissprot:YAIY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAIY_ECOLI PSORT-B swissprot:YAIY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAIY_ECOLI PSORT2 swissprot:YAIY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAIY_ECOLI Pfam PF10954 http://pfam.xfam.org/family/PF10954 Phobius swissprot:YAIY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAIY_ECOLI ProteinModelPortal P0AAP7 http://www.proteinmodelportal.org/query/uniprot/P0AAP7 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414913 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414913 RefSeq WP_000763151 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000763151 STRING 511145.b0379 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0379&targetmode=cogs UniProtKB YAIY_ECOLI http://www.uniprot.org/uniprot/YAIY_ECOLI UniProtKB-AC P0AAP7 http://www.uniprot.org/uniprot/P0AAP7 charge swissprot:YAIY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAIY_ECOLI eggNOG ENOG4105FR5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FR5 eggNOG ENOG4111PM6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111PM6 epestfind swissprot:YAIY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAIY_ECOLI garnier swissprot:YAIY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAIY_ECOLI helixturnhelix swissprot:YAIY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAIY_ECOLI hmoment swissprot:YAIY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAIY_ECOLI iep swissprot:YAIY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAIY_ECOLI inforesidue swissprot:YAIY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAIY_ECOLI octanol swissprot:YAIY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAIY_ECOLI pepcoil swissprot:YAIY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAIY_ECOLI pepdigest swissprot:YAIY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAIY_ECOLI pepinfo swissprot:YAIY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAIY_ECOLI pepnet swissprot:YAIY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAIY_ECOLI pepstats swissprot:YAIY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAIY_ECOLI pepwheel swissprot:YAIY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAIY_ECOLI pepwindow swissprot:YAIY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAIY_ECOLI sigcleave swissprot:YAIY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAIY_ECOLI ## Database ID URL or Descriptions # BioGrid 4260149 10 # EcoGene EG12870 ycjF # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # HAMAP MF_01085 UPF0283 # IntAct P0A8R7 5 # InterPro IPR006507 UPF0283 # InterPro IPR021147 DUF697 # Organism YCJF_ECOLI Escherichia coli (strain K12) # PATRIC 32117918 VBIEscCol129921_1379 # PIR E64881 E64881 # Pfam PF05128 DUF697 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCJF_ECOLI UPF0283 membrane protein YcjF # RefSeq NP_415838 NC_000913.3 # RefSeq WP_000138728 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0283 family. {ECO 0000305}. # SUBCELLULAR LOCATION YCJF_ECOLI Cell inner membrane; Multi-pass membrane protein. # TIGRFAMs TIGR01620 hyp_HI0043 # eggNOG COG3768 LUCA # eggNOG ENOG4106K28 Bacteria BLAST swissprot:YCJF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCJF_ECOLI BioCyc ECOL316407:JW1315-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1315-MONOMER BioCyc EcoCyc:EG12870-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12870-MONOMER COG COG3768 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3768 DIP DIP-48099N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48099N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M12114 http://www.ebi.ac.uk/ena/data/view/M12114 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2711 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2711 EcoGene EG12870 http://www.ecogene.org/geneInfo.php?eg_id=EG12870 EnsemblBacteria AAC74404 http://www.ensemblgenomes.org/id/AAC74404 EnsemblBacteria AAC74404 http://www.ensemblgenomes.org/id/AAC74404 EnsemblBacteria BAA14903 http://www.ensemblgenomes.org/id/BAA14903 EnsemblBacteria BAA14903 http://www.ensemblgenomes.org/id/BAA14903 EnsemblBacteria BAA14903 http://www.ensemblgenomes.org/id/BAA14903 EnsemblBacteria b1322 http://www.ensemblgenomes.org/id/b1322 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 945878 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945878 HAMAP MF_01085 http://hamap.expasy.org/unirule/MF_01085 HOGENOM HOG000276547 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276547&db=HOGENOM6 InParanoid P0A8R7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8R7 IntAct P0A8R7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8R7* InterPro IPR006507 http://www.ebi.ac.uk/interpro/entry/IPR006507 InterPro IPR021147 http://www.ebi.ac.uk/interpro/entry/IPR021147 KEGG_Gene ecj:JW1315 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1315 KEGG_Gene eco:b1322 http://www.genome.jp/dbget-bin/www_bget?eco:b1322 KEGG_Orthology KO:K08990 http://www.genome.jp/dbget-bin/www_bget?KO:K08990 MINT MINT-1265032 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1265032 OMA WRNIRLV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WRNIRLV PSORT swissprot:YCJF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCJF_ECOLI PSORT-B swissprot:YCJF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCJF_ECOLI PSORT2 swissprot:YCJF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCJF_ECOLI Pfam PF05128 http://pfam.xfam.org/family/PF05128 Phobius swissprot:YCJF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCJF_ECOLI ProteinModelPortal P0A8R7 http://www.proteinmodelportal.org/query/uniprot/P0A8R7 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3001057 http://www.ncbi.nlm.nih.gov/pubmed/3001057 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415838 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415838 RefSeq WP_000138728 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000138728 STRING 511145.b1322 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1322&targetmode=cogs STRING COG3768 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3768&targetmode=cogs TIGRFAMs TIGR01620 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01620 UniProtKB YCJF_ECOLI http://www.uniprot.org/uniprot/YCJF_ECOLI UniProtKB-AC P0A8R7 http://www.uniprot.org/uniprot/P0A8R7 charge swissprot:YCJF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCJF_ECOLI eggNOG COG3768 http://eggnogapi.embl.de/nog_data/html/tree/COG3768 eggNOG ENOG4106K28 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106K28 epestfind swissprot:YCJF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCJF_ECOLI garnier swissprot:YCJF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCJF_ECOLI helixturnhelix swissprot:YCJF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCJF_ECOLI hmoment swissprot:YCJF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCJF_ECOLI iep swissprot:YCJF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCJF_ECOLI inforesidue swissprot:YCJF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCJF_ECOLI octanol swissprot:YCJF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCJF_ECOLI pepcoil swissprot:YCJF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCJF_ECOLI pepdigest swissprot:YCJF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCJF_ECOLI pepinfo swissprot:YCJF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCJF_ECOLI pepnet swissprot:YCJF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCJF_ECOLI pepstats swissprot:YCJF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCJF_ECOLI pepwheel swissprot:YCJF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCJF_ECOLI pepwindow swissprot:YCJF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCJF_ECOLI sigcleave swissprot:YCJF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCJF_ECOLI ## Database ID URL or Descriptions # AltName FECD_ECOLI Iron(III) dicitrate transport system permease protein FecD # BioGrid 4262740 321 # EcoGene EG10289 fecD # FUNCTION FECD_ECOLI Part of the binding-protein-dependent transport system for citrate-dependent Fe(3+). Probably responsible for the translocation of the substrate across the membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005215 transporter activity; IEA:InterPro. # GO_process GO:0006811 ion transport; IEA:UniProtKB-KW. # GO_process GO:0055072 iron ion homeostasis; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006810 transport # GOslim_process GO:0042592 homeostatic process # Gene3D 1.10.3470.10 -; 1. # INDUCTION Induced 1.3-fold by hydroxyurea. {ECO:0000269|PubMed 20005847}. # InterPro IPR000522 ABC_transptr_FecCD # InterPro IPR029022 ABC_BtuC-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00240 Iron complex transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism FECD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30472 PTHR30472 # PATRIC 32124155 VBIEscCol129921_4421 # PIR S56513 QRECD2 # Pfam PF01032 FecCD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FECD_ECOLI Fe(3+) dicitrate transport system permease protein FecD # RefSeq NP_418708 NC_000913.3 # RefSeq WP_000684852 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION FECD_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF81345 SSF81345 # TCDB 3.A.1.14 the atp-binding cassette (abc) superfamily # eggNOG COG0609 LUCA # eggNOG ENOG4108IHU Bacteria BLAST swissprot:FECD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FECD_ECOLI BioCyc ECOL316407:JW4248-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4248-MONOMER BioCyc EcoCyc:FECD-MONOMER http://biocyc.org/getid?id=EcoCyc:FECD-MONOMER BioCyc MetaCyc:FECD-MONOMER http://biocyc.org/getid?id=MetaCyc:FECD-MONOMER COG COG0609 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0609 DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M26397 http://www.ebi.ac.uk/ena/data/view/M26397 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB0285 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0285 EcoGene EG10289 http://www.ecogene.org/geneInfo.php?eg_id=EG10289 EnsemblBacteria AAC77244 http://www.ensemblgenomes.org/id/AAC77244 EnsemblBacteria AAC77244 http://www.ensemblgenomes.org/id/AAC77244 EnsemblBacteria BAE78279 http://www.ensemblgenomes.org/id/BAE78279 EnsemblBacteria BAE78279 http://www.ensemblgenomes.org/id/BAE78279 EnsemblBacteria BAE78279 http://www.ensemblgenomes.org/id/BAE78279 EnsemblBacteria b4288 http://www.ensemblgenomes.org/id/b4288 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_process GO:0006811 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811 GO_process GO:0055072 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055072 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 Gene3D 1.10.3470.10 http://www.cathdb.info/version/latest/superfamily/1.10.3470.10 GeneID 946816 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946816 HOGENOM HOG000045409 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000045409&db=HOGENOM6 InParanoid P15029 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P15029 InterPro IPR000522 http://www.ebi.ac.uk/interpro/entry/IPR000522 InterPro IPR029022 http://www.ebi.ac.uk/interpro/entry/IPR029022 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW4248 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4248 KEGG_Gene eco:b4288 http://www.genome.jp/dbget-bin/www_bget?eco:b4288 KEGG_Orthology KO:K02015 http://www.genome.jp/dbget-bin/www_bget?KO:K02015 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA FYLLMRT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FYLLMRT PANTHER PTHR30472 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30472 PSORT swissprot:FECD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FECD_ECOLI PSORT-B swissprot:FECD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FECD_ECOLI PSORT2 swissprot:FECD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FECD_ECOLI Pfam PF01032 http://pfam.xfam.org/family/PF01032 Phobius swissprot:FECD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FECD_ECOLI PhylomeDB P15029 http://phylomedb.org/?seqid=P15029 ProteinModelPortal P15029 http://www.proteinmodelportal.org/query/uniprot/P15029 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 2651410 http://www.ncbi.nlm.nih.gov/pubmed/2651410 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418708 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418708 RefSeq WP_000684852 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000684852 STRING 511145.b4288 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4288&targetmode=cogs STRING COG0609 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0609&targetmode=cogs SUPFAM SSF81345 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81345 TCDB 3.A.1.14 http://www.tcdb.org/search/result.php?tc=3.A.1.14 UniProtKB FECD_ECOLI http://www.uniprot.org/uniprot/FECD_ECOLI UniProtKB-AC P15029 http://www.uniprot.org/uniprot/P15029 charge swissprot:FECD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FECD_ECOLI eggNOG COG0609 http://eggnogapi.embl.de/nog_data/html/tree/COG0609 eggNOG ENOG4108IHU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108IHU epestfind swissprot:FECD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FECD_ECOLI garnier swissprot:FECD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FECD_ECOLI helixturnhelix swissprot:FECD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FECD_ECOLI hmoment swissprot:FECD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FECD_ECOLI iep swissprot:FECD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FECD_ECOLI inforesidue swissprot:FECD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FECD_ECOLI octanol swissprot:FECD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FECD_ECOLI pepcoil swissprot:FECD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FECD_ECOLI pepdigest swissprot:FECD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FECD_ECOLI pepinfo swissprot:FECD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FECD_ECOLI pepnet swissprot:FECD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FECD_ECOLI pepstats swissprot:FECD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FECD_ECOLI pepwheel swissprot:FECD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FECD_ECOLI pepwindow swissprot:FECD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FECD_ECOLI sigcleave swissprot:FECD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FECD_ECOLI ## Database ID URL or Descriptions # AltName ESSQ_ECOLI Lysis protein S homolog from lambdoid prophage Qin # BioGrid 4262936 9 # EcoGene EG13831 essQ # GO_process GO:0019076 viral release from host cell; IEA:UniProtKB-KW. # GO_process GO:0019835 cytolysis; IEA:UniProtKB-KW. # GOslim_process GO:0008150 biological_process # GOslim_process GO:0040011 locomotion # GOslim_process GO:0044403 symbiosis, encompassing mutualism through parasitism # InterPro IPR007054 Lysis_S # Organism ESSQ_ECOLI Escherichia coli (strain K12) # PATRIC 32118414 VBIEscCol129921_1627 # PIR G64910 G64910 # PIRSF PIRSF030786 Lysis_S # Pfam PF04971 Phage_holin_2_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Prophage lysis protein S homolog EssQ {ECO 0000305} # RefSeq NP_416074 NC_000913.3 # RefSeq WP_000839590 NZ_LN832404.1 # SIMILARITY Belongs to the lambda phage S protein family. {ECO 0000305}. # TCDB 1.E.1.1 the p21 holin s (p21 holin) family # eggNOG ENOG4105QFS Bacteria # eggNOG ENOG4111XDG LUCA BLAST swissprot:ESSQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ESSQ_ECOLI BioCyc ECOL316407:JW5255-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5255-MONOMER BioCyc EcoCyc:G6829-MONOMER http://biocyc.org/getid?id=EcoCyc:G6829-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3592 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3592 EcoGene EG13831 http://www.ecogene.org/geneInfo.php?eg_id=EG13831 EnsemblBacteria AAC74629 http://www.ensemblgenomes.org/id/AAC74629 EnsemblBacteria AAC74629 http://www.ensemblgenomes.org/id/AAC74629 EnsemblBacteria BAA15255 http://www.ensemblgenomes.org/id/BAA15255 EnsemblBacteria BAA15255 http://www.ensemblgenomes.org/id/BAA15255 EnsemblBacteria BAA15255 http://www.ensemblgenomes.org/id/BAA15255 EnsemblBacteria b1556 http://www.ensemblgenomes.org/id/b1556 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0019076 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019076 GO_process GO:0019835 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019835 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0040011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011 GOslim_process GO:0044403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403 GeneID 946093 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946093 HOGENOM HOG000120019 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120019&db=HOGENOM6 InterPro IPR007054 http://www.ebi.ac.uk/interpro/entry/IPR007054 KEGG_Gene ecj:JW5255 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5255 KEGG_Gene eco:b1556 http://www.genome.jp/dbget-bin/www_bget?eco:b1556 OMA MLTYLTN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MLTYLTN PSORT swissprot:ESSQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ESSQ_ECOLI PSORT-B swissprot:ESSQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ESSQ_ECOLI PSORT2 swissprot:ESSQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ESSQ_ECOLI Pfam PF04971 http://pfam.xfam.org/family/PF04971 Phobius swissprot:ESSQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ESSQ_ECOLI ProteinModelPortal P77237 http://www.proteinmodelportal.org/query/uniprot/P77237 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416074 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416074 RefSeq WP_000839590 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000839590 STRING 511145.b1556 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1556&targetmode=cogs TCDB 1.E.1.1 http://www.tcdb.org/search/result.php?tc=1.E.1.1 UniProtKB ESSQ_ECOLI http://www.uniprot.org/uniprot/ESSQ_ECOLI UniProtKB-AC P77237 http://www.uniprot.org/uniprot/P77237 charge swissprot:ESSQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ESSQ_ECOLI eggNOG ENOG4105QFS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105QFS eggNOG ENOG4111XDG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111XDG epestfind swissprot:ESSQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ESSQ_ECOLI garnier swissprot:ESSQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ESSQ_ECOLI helixturnhelix swissprot:ESSQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ESSQ_ECOLI hmoment swissprot:ESSQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ESSQ_ECOLI iep swissprot:ESSQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ESSQ_ECOLI inforesidue swissprot:ESSQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ESSQ_ECOLI octanol swissprot:ESSQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ESSQ_ECOLI pepcoil swissprot:ESSQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ESSQ_ECOLI pepdigest swissprot:ESSQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ESSQ_ECOLI pepinfo swissprot:ESSQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ESSQ_ECOLI pepnet swissprot:ESSQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ESSQ_ECOLI pepstats swissprot:ESSQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ESSQ_ECOLI pepwheel swissprot:ESSQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ESSQ_ECOLI pepwindow swissprot:ESSQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ESSQ_ECOLI sigcleave swissprot:ESSQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ESSQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4261213 19 # CDD cd00885 cinA # EcoGene EG14087 yfaY # FUNCTION CINAL_ECOLI Does not have nicotinamide-nucleotide (NMN) amidohydrolase activity. # Gene3D 3.40.980.10 -; 1. # HAMAP MF_00226_B CinA_B # IntAct P77808 4 # InterPro IPR001453 MoaB/Mog_dom # InterPro IPR008135 Competence-induced_CinA # InterPro IPR008136 CinA_C # Organism CINAL_ECOLI Escherichia coli (strain K12) # PATRIC 32119861 VBIEscCol129921_2340 # PIR G64995 G64995 # PIRSF PIRSF006728 CinA # Pfam PF00994 MoCF_biosynth # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CINAL_ECOLI NMN amidohydrolase-like protein YfaY # RefSeq NP_416752 NC_000913.3 # RefSeq WP_000921621 NZ_LN832404.1 # SIMILARITY Belongs to the CinA family. {ECO:0000255|HAMAP- Rule MF_00226}. # SMART SM00852 MoCF_biosynth # SUPFAM SSF142433 SSF142433 # SUPFAM SSF53218 SSF53218 # TIGRFAMs TIGR00177 molyb_syn # TIGRFAMs TIGR00200 cinA_nterm # eggNOG COG1058 LUCA # eggNOG ENOG4107S37 Bacteria BLAST swissprot:CINAL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CINAL_ECOLI BioCyc ECOL316407:JW2243-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2243-MONOMER BioCyc EcoCyc:G7162-MONOMER http://biocyc.org/getid?id=EcoCyc:G7162-MONOMER COG COG1058 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1058 COG COG1546 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1546 DIP DIP-9281N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9281N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M111.275818 http://dx.doi.org/10.1074/jbc.M111.275818 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3840 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3840 EcoGene EG14087 http://www.ecogene.org/geneInfo.php?eg_id=EG14087 EnsemblBacteria AAC75309 http://www.ensemblgenomes.org/id/AAC75309 EnsemblBacteria AAC75309 http://www.ensemblgenomes.org/id/AAC75309 EnsemblBacteria BAA16073 http://www.ensemblgenomes.org/id/BAA16073 EnsemblBacteria BAA16073 http://www.ensemblgenomes.org/id/BAA16073 EnsemblBacteria BAA16073 http://www.ensemblgenomes.org/id/BAA16073 EnsemblBacteria b2249 http://www.ensemblgenomes.org/id/b2249 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.40.980.10 http://www.cathdb.info/version/latest/superfamily/3.40.980.10 GeneID 945478 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945478 HAMAP MF_00226_B http://hamap.expasy.org/unirule/MF_00226_B HOGENOM HOG000270991 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000270991&db=HOGENOM6 InParanoid P77808 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77808 IntAct P77808 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77808* InterPro IPR001453 http://www.ebi.ac.uk/interpro/entry/IPR001453 InterPro IPR008135 http://www.ebi.ac.uk/interpro/entry/IPR008135 InterPro IPR008136 http://www.ebi.ac.uk/interpro/entry/IPR008136 KEGG_Gene ecj:JW2243 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2243 KEGG_Gene eco:b2249 http://www.genome.jp/dbget-bin/www_bget?eco:b2249 KEGG_Orthology KO:K03742 http://www.genome.jp/dbget-bin/www_bget?KO:K03742 OMA AGLLNWQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AGLLNWQ PSORT swissprot:CINAL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CINAL_ECOLI PSORT-B swissprot:CINAL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CINAL_ECOLI PSORT2 swissprot:CINAL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CINAL_ECOLI Pfam PF00994 http://pfam.xfam.org/family/PF00994 Phobius swissprot:CINAL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CINAL_ECOLI PhylomeDB P77808 http://phylomedb.org/?seqid=P77808 ProteinModelPortal P77808 http://www.proteinmodelportal.org/query/uniprot/P77808 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21953451 http://www.ncbi.nlm.nih.gov/pubmed/21953451 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416752 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416752 RefSeq WP_000921621 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000921621 SMART SM00852 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00852 SMR P77808 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77808 STRING 511145.b2249 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2249&targetmode=cogs STRING COG1058 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1058&targetmode=cogs STRING COG1546 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1546&targetmode=cogs SUPFAM SSF142433 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF142433 SUPFAM SSF53218 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53218 TIGRFAMs TIGR00177 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00177 TIGRFAMs TIGR00200 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00200 UniProtKB CINAL_ECOLI http://www.uniprot.org/uniprot/CINAL_ECOLI UniProtKB-AC P77808 http://www.uniprot.org/uniprot/P77808 charge swissprot:CINAL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CINAL_ECOLI eggNOG COG1058 http://eggnogapi.embl.de/nog_data/html/tree/COG1058 eggNOG ENOG4107S37 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107S37 epestfind swissprot:CINAL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CINAL_ECOLI garnier swissprot:CINAL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CINAL_ECOLI helixturnhelix swissprot:CINAL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CINAL_ECOLI hmoment swissprot:CINAL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CINAL_ECOLI iep swissprot:CINAL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CINAL_ECOLI inforesidue swissprot:CINAL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CINAL_ECOLI octanol swissprot:CINAL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CINAL_ECOLI pepcoil swissprot:CINAL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CINAL_ECOLI pepdigest swissprot:CINAL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CINAL_ECOLI pepinfo swissprot:CINAL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CINAL_ECOLI pepnet swissprot:CINAL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CINAL_ECOLI pepstats swissprot:CINAL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CINAL_ECOLI pepwheel swissprot:CINAL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CINAL_ECOLI pepwindow swissprot:CINAL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CINAL_ECOLI sigcleave swissprot:CINAL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CINAL_ECOLI ## Database ID URL or Descriptions # AltName ATP synthase F(1) sector subunit delta {ECO:0000255|HAMAP-Rule MF_01416} # AltName F-type ATPase subunit delta {ECO:0000255|HAMAP-Rule MF_01416} # EcoGene EG10105 atpH # FUNCTION ATPD_ECOLI F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. # FUNCTION ATPD_ECOLI This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1); IMP:EcoliWiki. # GO_function GO:0046933 proton-transporting ATP synthase activity, rotational mechanism; IMP:EcoCyc. # GO_function GO:0046961 proton-transporting ATPase activity, rotational mechanism; IMP:EcoCyc. # GO_process GO:0015986 ATP synthesis coupled proton transport; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0055085 transmembrane transport # Gene3D 1.10.520.20 -; 1. # HAMAP MF_01416 ATP_synth_delta_bact # IntAct P0ABA4 13 # InterPro IPR000711 ATPase_OSCP/dsu # InterPro IPR020781 ATPase_OSCP/d_CS # InterPro IPR026015 ATP_synth_OSCP/delta_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko00194 Photosynthesis proteins # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00190 Oxidative phosphorylation # KEGG_Pathway ko00195 Photosynthesis # Organism ATPD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11910 PTHR11910 # PATRIC 32122967 VBIEscCol129921_3859 # PDB 1ABV NMR; -; A=2-135 # PDB 2A7U NMR; -; B=2-135 # PIR A93732 PWECD # PRINTS PR00125 ATPASEDELTA # PROSITE PS00389 ATPASE_DELTA # Pfam PF00213 OSCP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ATP synthase subunit delta {ECO:0000255|HAMAP-Rule MF_01416} # RefSeq NP_418191 NC_000913.3 # RefSeq WP_001288587 NZ_LN832404.1 # SIMILARITY Belongs to the ATPase delta chain family. {ECO:0000255|HAMAP-Rule MF_01416}. # SUBCELLULAR LOCATION ATPD_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01416, ECO 0000269|PubMed 16079137}; Peripheral membrane protein {ECO 0000255|HAMAP-Rule MF_01416, ECO 0000269|PubMed 16079137}. # SUBUNIT ATPD_ECOLI F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains. {ECO 0000255|HAMAP-Rule MF_01416, ECO 0000269|PubMed 16079137}. # SUPFAM SSF47928 SSF47928 # TCDB 3.A.2.1 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily # TIGRFAMs TIGR01145 ATP_synt_delta # eggNOG COG0712 LUCA # eggNOG ENOG4107S15 Bacteria BLAST swissprot:ATPD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ATPD_ECOLI BioCyc ECOL316407:JW3713-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3713-MONOMER BioCyc EcoCyc:ATPH-MONOMER http://biocyc.org/getid?id=EcoCyc:ATPH-MONOMER BioCyc MetaCyc:ATPH-MONOMER http://biocyc.org/getid?id=MetaCyc:ATPH-MONOMER COG COG0712 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0712 DIP DIP-47921N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47921N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1007/BF00271191 http://dx.doi.org/10.1007/BF00271191 DOI 10.1016/0006-291X(81)91504-7 http://dx.doi.org/10.1016/0006-291X(81)91504-7 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb0397-198 http://dx.doi.org/10.1038/nsb0397-198 DOI 10.1042/bj2240799 http://dx.doi.org/10.1042/bj2240799 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1093/nar/9.16.3919 http://dx.doi.org/10.1093/nar/9.16.3919 DOI 10.1111/j.1749-6632.1982.tb25731.x http://dx.doi.org/10.1111/j.1749-6632.1982.tb25731.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01594 http://www.ebi.ac.uk/ena/data/view/J01594 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M12212 http://www.ebi.ac.uk/ena/data/view/M12212 EMBL M25464 http://www.ebi.ac.uk/ena/data/view/M25464 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00264 http://www.ebi.ac.uk/ena/data/view/V00264 EMBL V00266 http://www.ebi.ac.uk/ena/data/view/V00266 EMBL X01631 http://www.ebi.ac.uk/ena/data/view/X01631 EchoBASE EB0103 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0103 EcoGene EG10105 http://www.ecogene.org/geneInfo.php?eg_id=EG10105 EnsemblBacteria AAC76758 http://www.ensemblgenomes.org/id/AAC76758 EnsemblBacteria AAC76758 http://www.ensemblgenomes.org/id/AAC76758 EnsemblBacteria BAE77553 http://www.ensemblgenomes.org/id/BAE77553 EnsemblBacteria BAE77553 http://www.ensemblgenomes.org/id/BAE77553 EnsemblBacteria BAE77553 http://www.ensemblgenomes.org/id/BAE77553 EnsemblBacteria b3735 http://www.ensemblgenomes.org/id/b3735 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0045261 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045261 GO_function GO:0046933 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046933 GO_function GO:0046961 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046961 GO_process GO:0015986 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015986 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 1.10.520.20 http://www.cathdb.info/version/latest/superfamily/1.10.520.20 GeneID 948254 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948254 HAMAP MF_01416 http://hamap.expasy.org/unirule/MF_01416 HOGENOM HOG000075824 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000075824&db=HOGENOM6 InParanoid P0ABA4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABA4 IntAct P0ABA4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABA4* InterPro IPR000711 http://www.ebi.ac.uk/interpro/entry/IPR000711 InterPro IPR020781 http://www.ebi.ac.uk/interpro/entry/IPR020781 InterPro IPR026015 http://www.ebi.ac.uk/interpro/entry/IPR026015 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko00194 http://www.genome.jp/dbget-bin/www_bget?ko00194 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3713 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3713 KEGG_Gene eco:b3735 http://www.genome.jp/dbget-bin/www_bget?eco:b3735 KEGG_Orthology KO:K02113 http://www.genome.jp/dbget-bin/www_bget?KO:K02113 KEGG_Pathway ko00190 http://www.genome.jp/kegg-bin/show_pathway?ko00190 KEGG_Pathway ko00195 http://www.genome.jp/kegg-bin/show_pathway?ko00195 OMA CGEQINE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CGEQINE PANTHER PTHR11910 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11910 PDB 1ABV http://www.ebi.ac.uk/pdbe-srv/view/entry/1ABV PDB 2A7U http://www.ebi.ac.uk/pdbe-srv/view/entry/2A7U PDBsum 1ABV http://www.ebi.ac.uk/pdbsum/1ABV PDBsum 2A7U http://www.ebi.ac.uk/pdbsum/2A7U PRINTS PR00125 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00125 PROSITE PS00389 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00389 PSORT swissprot:ATPD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ATPD_ECOLI PSORT-B swissprot:ATPD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ATPD_ECOLI PSORT2 swissprot:ATPD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ATPD_ECOLI Pfam PF00213 http://pfam.xfam.org/family/PF00213 Phobius swissprot:ATPD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ATPD_ECOLI PhylomeDB P0ABA4 http://phylomedb.org/?seqid=P0ABA4 ProteinModelPortal P0ABA4 http://www.proteinmodelportal.org/query/uniprot/P0ABA4 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6272190 http://www.ncbi.nlm.nih.gov/pubmed/6272190 PubMed 6278247 http://www.ncbi.nlm.nih.gov/pubmed/6278247 PubMed 6301339 http://www.ncbi.nlm.nih.gov/pubmed/6301339 PubMed 6395859 http://www.ncbi.nlm.nih.gov/pubmed/6395859 PubMed 6458296 http://www.ncbi.nlm.nih.gov/pubmed/6458296 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9164460 http://www.ncbi.nlm.nih.gov/pubmed/9164460 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418191 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418191 RefSeq WP_001288587 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001288587 SMR P0ABA4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABA4 STRING 511145.b3735 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3735&targetmode=cogs STRING COG0712 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0712&targetmode=cogs SUPFAM SSF47928 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47928 TCDB 3.A.2.1 http://www.tcdb.org/search/result.php?tc=3.A.2.1 TIGRFAMs TIGR01145 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01145 UniProtKB ATPD_ECOLI http://www.uniprot.org/uniprot/ATPD_ECOLI UniProtKB-AC P0ABA4 http://www.uniprot.org/uniprot/P0ABA4 charge swissprot:ATPD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ATPD_ECOLI eggNOG COG0712 http://eggnogapi.embl.de/nog_data/html/tree/COG0712 eggNOG ENOG4107S15 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107S15 epestfind swissprot:ATPD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ATPD_ECOLI garnier swissprot:ATPD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ATPD_ECOLI helixturnhelix swissprot:ATPD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ATPD_ECOLI hmoment swissprot:ATPD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ATPD_ECOLI iep swissprot:ATPD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ATPD_ECOLI inforesidue swissprot:ATPD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ATPD_ECOLI octanol swissprot:ATPD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ATPD_ECOLI pepcoil swissprot:ATPD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ATPD_ECOLI pepdigest swissprot:ATPD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ATPD_ECOLI pepinfo swissprot:ATPD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ATPD_ECOLI pepnet swissprot:ATPD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ATPD_ECOLI pepstats swissprot:ATPD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ATPD_ECOLI pepwheel swissprot:ATPD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ATPD_ECOLI pepwindow swissprot:ATPD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ATPD_ECOLI sigcleave swissprot:ATPD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ATPD_ECOLI ## Database ID URL or Descriptions # BioGrid 4259237 11 # EcoGene EG11323 ygfB # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # HAMAP MF_00346 UPF0149 # IntAct P0A8C4 7 # InterPro IPR011978 UPF0149 # Organism YGFB_ECOLI Escherichia coli (strain K12) # PATRIC 32121232 VBIEscCol129921_3004 # PIR A47020 A47020 # Pfam PF03695 UPF0149 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGFB_ECOLI UPF0149 protein YgfB # RefSeq NP_417385 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA69077.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA14324.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the UPF0149 family. {ECO 0000305}. # SUPFAM SSF101327 SSF101327 # TIGRFAMs TIGR02292 ygfB_yecA # eggNOG COG3079 LUCA # eggNOG ENOG4105E07 Bacteria BLAST swissprot:YGFB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGFB_ECOLI BioCyc ECOL316407:JW5473-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5473-MONOMER BioCyc EcoCyc:EG11323-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11323-MONOMER COG COG3079 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3079 DIP DIP-48191N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48191N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D90281 http://www.ebi.ac.uk/ena/data/view/D90281 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB1299 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1299 EcoGene EG11323 http://www.ecogene.org/geneInfo.php?eg_id=EG11323 EnsemblBacteria AAC75947 http://www.ensemblgenomes.org/id/AAC75947 EnsemblBacteria AAC75947 http://www.ensemblgenomes.org/id/AAC75947 EnsemblBacteria BAE76974 http://www.ensemblgenomes.org/id/BAE76974 EnsemblBacteria BAE76974 http://www.ensemblgenomes.org/id/BAE76974 EnsemblBacteria BAE76974 http://www.ensemblgenomes.org/id/BAE76974 EnsemblBacteria b2909 http://www.ensemblgenomes.org/id/b2909 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GeneID 947400 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947400 HAMAP MF_00346 http://hamap.expasy.org/unirule/MF_00346 HOGENOM HOG000276031 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276031&db=HOGENOM6 InParanoid P0A8C4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8C4 IntAct P0A8C4 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8C4* InterPro IPR011978 http://www.ebi.ac.uk/interpro/entry/IPR011978 KEGG_Gene ecj:JW5473 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5473 KEGG_Gene eco:b2909 http://www.genome.jp/dbget-bin/www_bget?eco:b2909 KEGG_Orthology KO:K09895 http://www.genome.jp/dbget-bin/www_bget?KO:K09895 OMA MRMSIQN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MRMSIQN PSORT swissprot:YGFB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGFB_ECOLI PSORT-B swissprot:YGFB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGFB_ECOLI PSORT2 swissprot:YGFB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGFB_ECOLI Pfam PF03695 http://pfam.xfam.org/family/PF03695 Phobius swissprot:YGFB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGFB_ECOLI ProteinModelPortal P0A8C4 http://www.proteinmodelportal.org/query/uniprot/P0A8C4 PubMed 1339425 http://www.ncbi.nlm.nih.gov/pubmed/1339425 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417385 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417385 SMR P0A8C4 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8C4 STRING 511145.b2909 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2909&targetmode=cogs STRING COG3079 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3079&targetmode=cogs SUPFAM SSF101327 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF101327 TIGRFAMs TIGR02292 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02292 UniProtKB YGFB_ECOLI http://www.uniprot.org/uniprot/YGFB_ECOLI UniProtKB-AC P0A8C4 http://www.uniprot.org/uniprot/P0A8C4 charge swissprot:YGFB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGFB_ECOLI eggNOG COG3079 http://eggnogapi.embl.de/nog_data/html/tree/COG3079 eggNOG ENOG4105E07 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E07 epestfind swissprot:YGFB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGFB_ECOLI garnier swissprot:YGFB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGFB_ECOLI helixturnhelix swissprot:YGFB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGFB_ECOLI hmoment swissprot:YGFB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGFB_ECOLI iep swissprot:YGFB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGFB_ECOLI inforesidue swissprot:YGFB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGFB_ECOLI octanol swissprot:YGFB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGFB_ECOLI pepcoil swissprot:YGFB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGFB_ECOLI pepdigest swissprot:YGFB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGFB_ECOLI pepinfo swissprot:YGFB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGFB_ECOLI pepnet swissprot:YGFB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGFB_ECOLI pepstats swissprot:YGFB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGFB_ECOLI pepwheel swissprot:YGFB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGFB_ECOLI pepwindow swissprot:YGFB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGFB_ECOLI sigcleave swissprot:YGFB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGFB_ECOLI ## Database ID URL or Descriptions # AltName LPTE_ECOLI Rare lipoprotein B # BioGrid 4260757 223 # EcoGene EG10855 lptE # FUNCTION LPTE_ECOLI Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane. {ECO 0000255|HAMAP-Rule MF_01186, ECO 0000269|PubMed 16861298, ECO 0000269|PubMed 18424520, ECO 0000269|PubMed 20203010}. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_function GO:0001530 lipopolysaccharide binding; IDA:EcoCyc. # GO_process GO:0015920 lipopolysaccharide transport; IMP:EcoCyc. # GO_process GO:0043165 Gram-negative-bacterium-type cell outer membrane assembly; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0008289 lipid binding # GOslim_process GO:0006810 transport # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0061024 membrane organization # HAMAP MF_01186 LPS_assembly_LptE # INTERACTION LPTE_ECOLI P31554 lptD; NbExp=3; IntAct=EBI-1119442, EBI-549369; # IntAct P0ADC1 6 # InterPro IPR007485 LPS_assembly_LptE # KEGG_Brite ko02000 Transporters # Organism LPTE_ECOLI Escherichia coli (strain K12) # PATRIC 32116465 VBIEscCol129921_0672 # PDB 4NHR X-ray; 2.34 A; A=20-182 # PDB 4RH8 X-ray; 2.20 A; A/B/C/D=20-186 # PDB 4RHB X-ray; 3.35 A; B/D=19-193 # PIR G64798 LPECRB # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF04390 LptE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LPS-assembly lipoprotein LptE {ECO:0000255|HAMAP-Rule MF_01186} # RefSeq NP_415174 NC_000913.3 # RefSeq WP_001269673 NZ_LN832404.1 # SIMILARITY Belongs to the LptE lipoprotein family. {ECO:0000255|HAMAP-Rule MF_01186}. # SUBCELLULAR LOCATION LPTE_ECOLI Cell outer membrane {ECO 0000255|HAMAP- Rule MF_01186, ECO 0000269|PubMed 20446753, ECO 0000269|PubMed 21257904, ECO 0000269|PubMed 3316191}; Lipid- anchor {ECO 0000255|HAMAP-Rule MF_01186, ECO 0000269|PubMed 20446753, ECO 0000269|PubMed 21257904, ECO 0000269|PubMed 3316191}. Note=A substantial portion is found inside the LptD beta-barrel. # SUBUNIT LPTE_ECOLI Component of the lipopolysaccharide transport and assembly complex. Interacts with LptD. May interact with LptD during its assembly by the beta-barrel assembly machine. Directly contacts LptD at a wide range of positions, encompassing multiple surfaces of LptE. In one specific interaction, LptE contacts a predicted extracellular loop of LptD through the lumen of the beta-barrel. This specific interaction is required for proper folding of LptD and assembly of the complex. {ECO 0000255|HAMAP- Rule MF_01186, ECO 0000269|PubMed 16861298, ECO 0000269|PubMed 20203010, ECO 0000269|PubMed 21257904, ECO 0000269|PubMed 21257909}. # TCDB 1.B.42.1 the outer membrane lipopolysaccharide export porin (lps-ep) family # eggNOG COG2980 LUCA # eggNOG ENOG4108U2H Bacteria BLAST swissprot:LPTE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LPTE_ECOLI BioCyc ECOL316407:JW0636-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0636-MONOMER BioCyc EcoCyc:EG10855-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10855-MONOMER BioCyc MetaCyc:EG10855-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10855-MONOMER COG COG2980 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2980 DIP DIP-35987N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35987N DOI 10.1021/bi100493e http://dx.doi.org/10.1021/bi100493e DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0604744103 http://dx.doi.org/10.1073/pnas.0604744103 DOI 10.1073/pnas.0912872107 http://dx.doi.org/10.1073/pnas.0912872107 DOI 10.1073/pnas.1015617108 http://dx.doi.org/10.1073/pnas.1015617108 DOI 10.1073/pnas.1019089108 http://dx.doi.org/10.1073/pnas.1019089108 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00270-08 http://dx.doi.org/10.1128/JB.00270-08 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M18277 http://www.ebi.ac.uk/ena/data/view/M18277 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB0848 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0848 EcoGene EG10855 http://www.ecogene.org/geneInfo.php?eg_id=EG10855 EnsemblBacteria AAC73742 http://www.ensemblgenomes.org/id/AAC73742 EnsemblBacteria AAC73742 http://www.ensemblgenomes.org/id/AAC73742 EnsemblBacteria BAA35288 http://www.ensemblgenomes.org/id/BAA35288 EnsemblBacteria BAA35288 http://www.ensemblgenomes.org/id/BAA35288 EnsemblBacteria BAA35288 http://www.ensemblgenomes.org/id/BAA35288 EnsemblBacteria b0641 http://www.ensemblgenomes.org/id/b0641 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_function GO:0001530 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001530 GO_process GO:0015920 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015920 GO_process GO:0043165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043165 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0008289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0061024 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024 GeneID 946257 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946257 HAMAP MF_01186 http://hamap.expasy.org/unirule/MF_01186 HOGENOM HOG000256192 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000256192&db=HOGENOM6 IntAct P0ADC1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADC1* InterPro IPR007485 http://www.ebi.ac.uk/interpro/entry/IPR007485 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0636 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0636 KEGG_Gene eco:b0641 http://www.genome.jp/dbget-bin/www_bget?eco:b0641 KEGG_Orthology KO:K03643 http://www.genome.jp/dbget-bin/www_bget?KO:K03643 OMA RKLLTVH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RKLLTVH PDB 4NHR http://www.ebi.ac.uk/pdbe-srv/view/entry/4NHR PDB 4RH8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4RH8 PDB 4RHB http://www.ebi.ac.uk/pdbe-srv/view/entry/4RHB PDBsum 4NHR http://www.ebi.ac.uk/pdbsum/4NHR PDBsum 4RH8 http://www.ebi.ac.uk/pdbsum/4RH8 PDBsum 4RHB http://www.ebi.ac.uk/pdbsum/4RHB PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:LPTE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LPTE_ECOLI PSORT-B swissprot:LPTE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LPTE_ECOLI PSORT2 swissprot:LPTE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LPTE_ECOLI Pfam PF04390 http://pfam.xfam.org/family/PF04390 Phobius swissprot:LPTE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LPTE_ECOLI ProteinModelPortal P0ADC1 http://www.proteinmodelportal.org/query/uniprot/P0ADC1 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16861298 http://www.ncbi.nlm.nih.gov/pubmed/16861298 PubMed 18424520 http://www.ncbi.nlm.nih.gov/pubmed/18424520 PubMed 20203010 http://www.ncbi.nlm.nih.gov/pubmed/20203010 PubMed 20446753 http://www.ncbi.nlm.nih.gov/pubmed/20446753 PubMed 21257904 http://www.ncbi.nlm.nih.gov/pubmed/21257904 PubMed 21257909 http://www.ncbi.nlm.nih.gov/pubmed/21257909 PubMed 3316191 http://www.ncbi.nlm.nih.gov/pubmed/3316191 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415174 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415174 RefSeq WP_001269673 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001269673 SMR P0ADC1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADC1 STRING 511145.b0641 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0641&targetmode=cogs STRING COG2980 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2980&targetmode=cogs TCDB 1.B.42.1 http://www.tcdb.org/search/result.php?tc=1.B.42.1 UniProtKB LPTE_ECOLI http://www.uniprot.org/uniprot/LPTE_ECOLI UniProtKB-AC P0ADC1 http://www.uniprot.org/uniprot/P0ADC1 charge swissprot:LPTE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LPTE_ECOLI eggNOG COG2980 http://eggnogapi.embl.de/nog_data/html/tree/COG2980 eggNOG ENOG4108U2H http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108U2H epestfind swissprot:LPTE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LPTE_ECOLI garnier swissprot:LPTE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LPTE_ECOLI helixturnhelix swissprot:LPTE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LPTE_ECOLI hmoment swissprot:LPTE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LPTE_ECOLI iep swissprot:LPTE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LPTE_ECOLI inforesidue swissprot:LPTE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LPTE_ECOLI octanol swissprot:LPTE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LPTE_ECOLI pepcoil swissprot:LPTE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LPTE_ECOLI pepdigest swissprot:LPTE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LPTE_ECOLI pepinfo swissprot:LPTE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LPTE_ECOLI pepnet swissprot:LPTE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LPTE_ECOLI pepstats swissprot:LPTE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LPTE_ECOLI pepwheel swissprot:LPTE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LPTE_ECOLI pepwindow swissprot:LPTE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LPTE_ECOLI sigcleave swissprot:LPTE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LPTE_ECOLI ## Database ID URL or Descriptions # AltName NAPB_ECOLI Diheme cytochrome c NapB # BRENDA 1.9.6 2165 # BioGrid 4262224 21 # DISRUPTION PHENOTYPE Deletion leads to reduced levels of formate- or glycerol-dependent activity after anaerobic growth in the presence of nitrate. {ECO:0000269|PubMed 10548535}. # EcoGene EG12061 napB # FUNCTION NAPB_ECOLI Electron transfer subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from the membrane- anchored tetraheme c-type NapC protein and transfers these to NapA subunit, thus allowing electron flow between membrane and periplasm. Essential for periplasmic nitrate reduction with nitrate as the terminal electron acceptor. {ECO 0000269|PubMed 10234835, ECO 0000269|PubMed 10548535, ECO 0000269|PubMed 17130127}. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0009061 anaerobic respiration; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # Gene3D 4.10.1020.10 -; 1. # InterPro IPR005591 NapB # InterPro IPR011031 Multihaem_cyt # InterPro IPR027406 NapB_heme-bd # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Pathway ko00910 Nitrogen metabolism # Organism NAPB_ECOLI Escherichia coli (strain K12) # PATRIC 32119765 VBIEscCol129921_2292 # PIRSF PIRSF006105 NapB # PROSITE PS51008 MULTIHEME_CYTC # PTM NAPB_ECOLI Binds 2 heme C groups per subunit. # Pfam PF03892 NapB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NAPB_ECOLI Periplasmic nitrate reductase, electron transfer subunit # RefSeq NP_416707 NC_000913.3 # RefSeq WP_000835174 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA16395.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the NapB family. {ECO 0000305}. # SUBCELLULAR LOCATION NAPB_ECOLI Periplasm {ECO 0000269|PubMed 10234835, ECO 0000269|PubMed 10548535, ECO 0000269|PubMed 17130127}. # SUBUNIT NAPB_ECOLI Component of the periplasmic nitrate reductase NapAB complex composed of NapA and NapB. The interaction between NapA and NapB is weak. {ECO 0000269|PubMed 10234835, ECO 0000269|PubMed 17130127}. # SUPFAM SSF48695 SSF48695 # eggNOG COG3043 LUCA # eggNOG ENOG4108ZMS Bacteria BLAST swissprot:NAPB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NAPB_ECOLI BioCyc ECOL316407:JW5367-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5367-MONOMER BioCyc EcoCyc:NAPB-MONOMER http://biocyc.org/getid?id=EcoCyc:NAPB-MONOMER BioCyc MetaCyc:NAPB-MONOMER http://biocyc.org/getid?id=MetaCyc:NAPB-MONOMER COG COG3043 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3043 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj3440069 http://dx.doi.org/10.1042/bj3440069 DOI 10.1074/jbc.M607353200 http://dx.doi.org/10.1074/jbc.M607353200 DOI 10.1111/j.1574-6968.1994.tb06872.x http://dx.doi.org/10.1111/j.1574-6968.1994.tb06872.x DOI 10.1111/j.1574-6968.1999.tb13564.x http://dx.doi.org/10.1111/j.1574-6968.1999.tb13564.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00008 http://www.ebi.ac.uk/ena/data/view/U00008 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1991 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1991 EcoGene EG12061 http://www.ecogene.org/geneInfo.php?eg_id=EG12061 EnsemblBacteria AAC75263 http://www.ensemblgenomes.org/id/AAC75263 EnsemblBacteria AAC75263 http://www.ensemblgenomes.org/id/AAC75263 EnsemblBacteria BAE76666 http://www.ensemblgenomes.org/id/BAE76666 EnsemblBacteria BAE76666 http://www.ensemblgenomes.org/id/BAE76666 EnsemblBacteria BAE76666 http://www.ensemblgenomes.org/id/BAE76666 EnsemblBacteria b2203 http://www.ensemblgenomes.org/id/b2203 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0009061 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009061 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 Gene3D 4.10.1020.10 http://www.cathdb.info/version/latest/superfamily/4.10.1020.10 GeneID 946698 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946698 HOGENOM HOG000275521 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275521&db=HOGENOM6 InParanoid P0ABL3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABL3 InterPro IPR005591 http://www.ebi.ac.uk/interpro/entry/IPR005591 InterPro IPR011031 http://www.ebi.ac.uk/interpro/entry/IPR011031 InterPro IPR027406 http://www.ebi.ac.uk/interpro/entry/IPR027406 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Gene ecj:JW5367 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5367 KEGG_Gene eco:b2203 http://www.genome.jp/dbget-bin/www_bget?eco:b2203 KEGG_Orthology KO:K02568 http://www.genome.jp/dbget-bin/www_bget?KO:K02568 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Reaction rn:R00798 http://www.genome.jp/dbget-bin/www_bget?rn:R00798 OMA PIVDNTF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PIVDNTF PROSITE PS51008 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51008 PSORT swissprot:NAPB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NAPB_ECOLI PSORT-B swissprot:NAPB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NAPB_ECOLI PSORT2 swissprot:NAPB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NAPB_ECOLI Pfam PF03892 http://pfam.xfam.org/family/PF03892 Phobius swissprot:NAPB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NAPB_ECOLI PhylomeDB P0ABL3 http://phylomedb.org/?seqid=P0ABL3 ProteinModelPortal P0ABL3 http://www.proteinmodelportal.org/query/uniprot/P0ABL3 PubMed 10234835 http://www.ncbi.nlm.nih.gov/pubmed/10234835 PubMed 10548535 http://www.ncbi.nlm.nih.gov/pubmed/10548535 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17130127 http://www.ncbi.nlm.nih.gov/pubmed/17130127 PubMed 8039676 http://www.ncbi.nlm.nih.gov/pubmed/8039676 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416707 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416707 RefSeq WP_000835174 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000835174 STRING 511145.b2203 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2203&targetmode=cogs STRING COG3043 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3043&targetmode=cogs SUPFAM SSF48695 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48695 UniProtKB NAPB_ECOLI http://www.uniprot.org/uniprot/NAPB_ECOLI UniProtKB-AC P0ABL3 http://www.uniprot.org/uniprot/P0ABL3 charge swissprot:NAPB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NAPB_ECOLI eggNOG COG3043 http://eggnogapi.embl.de/nog_data/html/tree/COG3043 eggNOG ENOG4108ZMS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZMS epestfind swissprot:NAPB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NAPB_ECOLI garnier swissprot:NAPB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NAPB_ECOLI helixturnhelix swissprot:NAPB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NAPB_ECOLI hmoment swissprot:NAPB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NAPB_ECOLI iep swissprot:NAPB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NAPB_ECOLI inforesidue swissprot:NAPB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NAPB_ECOLI octanol swissprot:NAPB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NAPB_ECOLI pepcoil swissprot:NAPB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NAPB_ECOLI pepdigest swissprot:NAPB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NAPB_ECOLI pepinfo swissprot:NAPB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NAPB_ECOLI pepnet swissprot:NAPB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NAPB_ECOLI pepstats swissprot:NAPB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NAPB_ECOLI pepwheel swissprot:NAPB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NAPB_ECOLI pepwindow swissprot:NAPB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NAPB_ECOLI sigcleave swissprot:NAPB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NAPB_ECOLI ## Database ID URL or Descriptions # AltName MSCK_ECOLI Potassium efflux system KefA # BioGrid 4259842 245 # EcoGene EG14240 mscK # FUNCTION MSCK_ECOLI Mechanosensitive channel that opens in response to membrane tension and specific ionic conditions. Requires high concentrations of external K(+), NH(4)(+), Rb(+) or Cs(+) to gate. May participate in the regulation of osmotic pressure changes within the cell, although it does not appear to have a major role in osmolarity regulation. Forms an ion channel of 1.0 nanosiemens conductance. The channel can remain active for between 30 seconds and over 3 minutes; it does not desensitize upon extended pressure. Its activity is masked in wild-type cells by the MscS channel. {ECO 0000269|PubMed 10202137, ECO 0000269|PubMed 11985727, ECO 0000269|PubMed 12374733}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006813 potassium ion transport; IEA:UniProtKB-KW. # GO_process GO:0009992 cellular water homeostasis; IMP:EcoCyc. # GO_process GO:0055085 transmembrane transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006810 transport # GOslim_process GO:0042592 homeostatic process # GOslim_process GO:0055085 transmembrane transport # IntAct P77338 3 # InterPro IPR006685 MscS_channel # InterPro IPR006686 MscS_channel_CS # InterPro IPR010920 LSM_dom # InterPro IPR011014 MscS_channel_TM-2 # InterPro IPR011066 MscC_channel_C # InterPro IPR024393 MscS_porin # InterPro IPR025692 MscS_IM_dom1 # KEGG_Brite ko02000 Transporters # Organism MSCK_ECOLI Escherichia coli (strain K12) # PATRIC 32116083 VBIEscCol129921_0483 # PIR H64776 H64776 # PROSITE PS01246 UPF0003 # Pfam PF00924 MS_channel # Pfam PF12794 MscS_TM # Pfam PF12795 MscS_porin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MSCK_ECOLI Mechanosensitive channel MscK # RefSeq NP_414998 NC_000913.3 # RefSeq WP_000177732 NZ_LN832404.1 # SIMILARITY Belongs to the MscS (TC 1.A.23) family. {ECO 0000305}. # SUBCELLULAR LOCATION MSCK_ECOLI Cell inner membrane {ECO 0000269|PubMed 11985727, ECO 0000269|PubMed 15919996}; Multi- pass membrane protein {ECO 0000269|PubMed 11985727, ECO 0000269|PubMed 15919996}. # SUPFAM SSF50182 SSF50182 # SUPFAM SSF82689 SSF82689 # SUPFAM SSF82861 SSF82861 # TCDB 1.A.23.1 the small conductance mechanosensitive ion channel (mscs) family # eggNOG COG3264 LUCA # eggNOG ENOG4105EGS Bacteria BLAST swissprot:MSCK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MSCK_ECOLI BioCyc ECOL316407:JW0454-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0454-MONOMER BioCyc EcoCyc:G6255-MONOMER http://biocyc.org/getid?id=EcoCyc:G6255-MONOMER COG COG3264 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3264 DIP DIP-10070N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10070N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2002.02764.x http://dx.doi.org/10.1046/j.1365-2958.2002.02764.x DOI 10.1093/emboj/18.7.1730 http://dx.doi.org/10.1093/emboj/18.7.1730 DOI 10.1093/emboj/cdf537 http://dx.doi.org/10.1093/emboj/cdf537 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL Y07802 http://www.ebi.ac.uk/ena/data/view/Y07802 EchoBASE EB3991 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3991 EcoGene EG14240 http://www.ecogene.org/geneInfo.php?eg_id=EG14240 EnsemblBacteria AAC73567 http://www.ensemblgenomes.org/id/AAC73567 EnsemblBacteria AAC73567 http://www.ensemblgenomes.org/id/AAC73567 EnsemblBacteria BAE76244 http://www.ensemblgenomes.org/id/BAE76244 EnsemblBacteria BAE76244 http://www.ensemblgenomes.org/id/BAE76244 EnsemblBacteria BAE76244 http://www.ensemblgenomes.org/id/BAE76244 EnsemblBacteria b0465 http://www.ensemblgenomes.org/id/b0465 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006813 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813 GO_process GO:0009992 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009992 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 945132 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945132 HOGENOM HOG000280842 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000280842&db=HOGENOM6 InParanoid P77338 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77338 IntAct P77338 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77338* InterPro IPR006685 http://www.ebi.ac.uk/interpro/entry/IPR006685 InterPro IPR006686 http://www.ebi.ac.uk/interpro/entry/IPR006686 InterPro IPR010920 http://www.ebi.ac.uk/interpro/entry/IPR010920 InterPro IPR011014 http://www.ebi.ac.uk/interpro/entry/IPR011014 InterPro IPR011066 http://www.ebi.ac.uk/interpro/entry/IPR011066 InterPro IPR024393 http://www.ebi.ac.uk/interpro/entry/IPR024393 InterPro IPR025692 http://www.ebi.ac.uk/interpro/entry/IPR025692 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0454 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0454 KEGG_Gene eco:b0465 http://www.genome.jp/dbget-bin/www_bget?eco:b0465 KEGG_Orthology KO:K05802 http://www.genome.jp/dbget-bin/www_bget?KO:K05802 OMA LHTPKAI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LHTPKAI PROSITE PS01246 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01246 PSORT swissprot:MSCK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MSCK_ECOLI PSORT-B swissprot:MSCK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MSCK_ECOLI PSORT2 swissprot:MSCK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MSCK_ECOLI Pfam PF00924 http://pfam.xfam.org/family/PF00924 Pfam PF12794 http://pfam.xfam.org/family/PF12794 Pfam PF12795 http://pfam.xfam.org/family/PF12795 Phobius swissprot:MSCK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MSCK_ECOLI PhylomeDB P77338 http://phylomedb.org/?seqid=P77338 ProteinModelPortal P77338 http://www.proteinmodelportal.org/query/uniprot/P77338 PubMed 10202137 http://www.ncbi.nlm.nih.gov/pubmed/10202137 PubMed 11985727 http://www.ncbi.nlm.nih.gov/pubmed/11985727 PubMed 12374733 http://www.ncbi.nlm.nih.gov/pubmed/12374733 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414998 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414998 RefSeq WP_000177732 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000177732 SMR P77338 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77338 STRING 511145.b0465 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0465&targetmode=cogs STRING COG3264 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3264&targetmode=cogs SUPFAM SSF50182 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50182 SUPFAM SSF82689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF82689 SUPFAM SSF82861 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF82861 TCDB 1.A.23.1 http://www.tcdb.org/search/result.php?tc=1.A.23.1 UniProtKB MSCK_ECOLI http://www.uniprot.org/uniprot/MSCK_ECOLI UniProtKB-AC P77338 http://www.uniprot.org/uniprot/P77338 charge swissprot:MSCK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MSCK_ECOLI eggNOG COG3264 http://eggnogapi.embl.de/nog_data/html/tree/COG3264 eggNOG ENOG4105EGS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EGS epestfind swissprot:MSCK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MSCK_ECOLI garnier swissprot:MSCK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MSCK_ECOLI helixturnhelix swissprot:MSCK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MSCK_ECOLI hmoment swissprot:MSCK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MSCK_ECOLI iep swissprot:MSCK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MSCK_ECOLI inforesidue swissprot:MSCK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MSCK_ECOLI octanol swissprot:MSCK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MSCK_ECOLI pepcoil swissprot:MSCK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MSCK_ECOLI pepdigest swissprot:MSCK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MSCK_ECOLI pepinfo swissprot:MSCK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MSCK_ECOLI pepnet swissprot:MSCK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MSCK_ECOLI pepstats swissprot:MSCK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MSCK_ECOLI pepwheel swissprot:MSCK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MSCK_ECOLI pepwindow swissprot:MSCK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MSCK_ECOLI sigcleave swissprot:MSCK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MSCK_ECOLI ## Database ID URL or Descriptions # GO_function GO:0003677 DNA binding; IEA:InterPro. # GOslim_function GO:0003677 DNA binding # InterPro IPR003115 ParB/Sulfiredoxin_dom # InterPro IPR004437 ParB/RepB/Spo0J # Organism YUBM_ECOLI Escherichia coli (strain K12) # Pfam PF02195 ParBc # RecName YUBM_ECOLI Uncharacterized protein YubM # RefSeq NP_061441 NC_002483.1 # RefSeq WP_000117173 NZ_CP014273.1 # SIMILARITY Belongs to the ParB family. {ECO 0000305}. # SMART SM00470 ParB # SUPFAM SSF110849 SSF110849 # TIGRFAMs TIGR00180 parB_part BLAST swissprot:YUBM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YUBM_ECOLI DOI 10.1006/plas.1999.1390 http://dx.doi.org/10.1006/plas.1999.1390 EMBL AF106329 http://www.ebi.ac.uk/ena/data/view/AF106329 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GeneID 1263594 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263594 IntAct Q9S4W2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q9S4W2* InterPro IPR003115 http://www.ebi.ac.uk/interpro/entry/IPR003115 InterPro IPR004437 http://www.ebi.ac.uk/interpro/entry/IPR004437 OMA SLECEHY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SLECEHY PSORT swissprot:YUBM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YUBM_ECOLI PSORT-B swissprot:YUBM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YUBM_ECOLI PSORT2 swissprot:YUBM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YUBM_ECOLI Pfam PF02195 http://pfam.xfam.org/family/PF02195 Phobius swissprot:YUBM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YUBM_ECOLI PhylomeDB Q9S4W2 http://phylomedb.org/?seqid=Q9S4W2 ProteinModelPortal Q9S4W2 http://www.proteinmodelportal.org/query/uniprot/Q9S4W2 PubMed 10366527 http://www.ncbi.nlm.nih.gov/pubmed/10366527 RefSeq NP_061441 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061441 RefSeq WP_000117173 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000117173 SMART SM00470 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00470 SMR Q9S4W2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9S4W2 SUPFAM SSF110849 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF110849 TIGRFAMs TIGR00180 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00180 UniProtKB YUBM_ECOLI http://www.uniprot.org/uniprot/YUBM_ECOLI UniProtKB-AC Q9S4W2 http://www.uniprot.org/uniprot/Q9S4W2 charge swissprot:YUBM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YUBM_ECOLI epestfind swissprot:YUBM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YUBM_ECOLI garnier swissprot:YUBM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YUBM_ECOLI helixturnhelix swissprot:YUBM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YUBM_ECOLI hmoment swissprot:YUBM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YUBM_ECOLI iep swissprot:YUBM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YUBM_ECOLI inforesidue swissprot:YUBM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YUBM_ECOLI octanol swissprot:YUBM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YUBM_ECOLI pepcoil swissprot:YUBM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YUBM_ECOLI pepdigest swissprot:YUBM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YUBM_ECOLI pepinfo swissprot:YUBM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YUBM_ECOLI pepnet swissprot:YUBM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YUBM_ECOLI pepstats swissprot:YUBM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YUBM_ECOLI pepwheel swissprot:YUBM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YUBM_ECOLI pepwindow swissprot:YUBM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YUBM_ECOLI sigcleave swissprot:YUBM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YUBM_ECOLI ## Database ID URL or Descriptions # AltName ILVI_ECOLI AHAS-III # AltName ILVI_ECOLI ALS-III # AltName ILVI_ECOLI Acetohydroxy-acid synthase III large subunit # BioGrid 4259380 7 # CATALYTIC ACTIVITY ILVI_ECOLI 2 pyruvate = 2-acetolactate + CO(2). # COFACTOR ILVI_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250}; Note=Binds 1 Mg(2+) ion per subunit. {ECO 0000250}; # COFACTOR ILVI_ECOLI Name=thiamine diphosphate; Xref=ChEBI CHEBI 58937; Evidence={ECO 0000250}; Note=Binds 1 thiamine pyrophosphate per subunit. {ECO 0000250}; # ENZYME REGULATION ILVI_ECOLI Sensitive to valine inhibition. # EcoGene EG10500 ilvI # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0003984 acetolactate synthase activity; IDA:EcoCyc. # GO_function GO:0030976 thiamine pyrophosphate binding; IDA:EcoCyc. # GO_function GO:0050660 flavin adenine dinucleotide binding; IEA:InterPro. # GO_process GO:0009097 isoleucine biosynthetic process; IDA:EcoCyc. # GO_process GO:0009099 valine biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.1220 -; 1. # Gene3D 3.40.50.970 -; 2. # IntAct P00893 7 # InterPro IPR000399 TPP-bd_CS # InterPro IPR011766 TPP_enzyme-bd_C # InterPro IPR012000 Thiamin_PyroP_enz_cen_dom # InterPro IPR012001 Thiamin_PyroP_enz_TPP-bd_dom # InterPro IPR012846 Acetolactate_synth_lsu # InterPro IPR029035 DHS-like_NAD/FAD-binding_dom # InterPro IPR029061 THDP-binding # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00290 Valine, leucine and isoleucine biosynthesis # KEGG_Pathway ko00650 Butanoate metabolism # KEGG_Pathway ko00660 C5-Branched dibasic acid metabolism # KEGG_Pathway ko00770 Pantothenate and CoA biosynthesis # MISCELLANEOUS Contains 1 molecule of FAD per monomer. The role of this cofactor is not clear considering that the reaction does not involve redox chemistry (By similarity). {ECO 0000250}. # MISCELLANEOUS E.coli contains genes for 3 AHAS isozymes ilvBN, ilvGM and ilvIH. # Organism ILVI_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-isoleucine biosynthesis; L- isoleucine from 2-oxobutanoate step 1/4. # PATHWAY Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate step 1/4. # PATRIC 32115257 VBIEscCol129921_0080 # PIR E64729 YCEC3I # PROSITE PS00187 TPP_ENZYMES # Pfam PF00205 TPP_enzyme_M # Pfam PF02775 TPP_enzyme_C # Pfam PF02776 TPP_enzyme_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ILVI_ECOLI Acetolactate synthase isozyme 3 large subunit # RefSeq WP_001295534 NZ_LN832404.1 # RefSeq YP_025294 NC_000913.3 # SEQUENCE CAUTION Sequence=CAA25755.1; Type=Frameshift; Positions=523; Evidence={ECO 0000305}; # SIMILARITY Belongs to the TPP enzyme family. {ECO 0000305}. # SUBUNIT ILVI_ECOLI Dimer of large and small chains. # SUPFAM SSF52467 SSF52467 # SUPFAM SSF52518 SSF52518; 2 # TIGRFAMs TIGR00118 acolac_lg # UniPathway UPA00047 UER00055 # UniPathway UPA00049 UER00059 # eggNOG COG0028 LUCA # eggNOG ENOG4105C7K Bacteria BLAST swissprot:ILVI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ILVI_ECOLI BioCyc ECOL316407:JW0076-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0076-MONOMER BioCyc EcoCyc:ACETOLACTSYNIII-ICHAIN-MONOMER http://biocyc.org/getid?id=EcoCyc:ACETOLACTSYNIII-ICHAIN-MONOMER BioCyc MetaCyc:ACETOLACTSYNIII-ICHAIN-MONOMER http://biocyc.org/getid?id=MetaCyc:ACETOLACTSYNIII-ICHAIN-MONOMER COG COG0028 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0028 DIP DIP-6850N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-6850N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/11.15.5299 http://dx.doi.org/10.1093/nar/11.15.5299 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.2.1.6 http://www.genome.jp/dbget-bin/www_bget?EC:2.2.1.6 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M10738 http://www.ebi.ac.uk/ena/data/view/M10738 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X01609 http://www.ebi.ac.uk/ena/data/view/X01609 EMBL X55034 http://www.ebi.ac.uk/ena/data/view/X55034 ENZYME 2.2.1.6 http://enzyme.expasy.org/EC/2.2.1.6 EchoBASE EB0495 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0495 EcoGene EG10500 http://www.ecogene.org/geneInfo.php?eg_id=EG10500 EnsemblBacteria AAC73188 http://www.ensemblgenomes.org/id/AAC73188 EnsemblBacteria AAC73188 http://www.ensemblgenomes.org/id/AAC73188 EnsemblBacteria BAB96646 http://www.ensemblgenomes.org/id/BAB96646 EnsemblBacteria BAB96646 http://www.ensemblgenomes.org/id/BAB96646 EnsemblBacteria BAB96646 http://www.ensemblgenomes.org/id/BAB96646 EnsemblBacteria b0077 http://www.ensemblgenomes.org/id/b0077 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0003984 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003984 GO_function GO:0030976 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030976 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_process GO:0009097 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009097 GO_process GO:0009099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009099 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.1220 http://www.cathdb.info/version/latest/superfamily/3.40.50.1220 Gene3D 3.40.50.970 http://www.cathdb.info/version/latest/superfamily/3.40.50.970 GeneID 948793 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948793 HOGENOM HOG000258448 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000258448&db=HOGENOM6 InParanoid P00893 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00893 IntAct P00893 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00893* IntEnz 2.2.1.6 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.2.1.6 InterPro IPR000399 http://www.ebi.ac.uk/interpro/entry/IPR000399 InterPro IPR011766 http://www.ebi.ac.uk/interpro/entry/IPR011766 InterPro IPR012000 http://www.ebi.ac.uk/interpro/entry/IPR012000 InterPro IPR012001 http://www.ebi.ac.uk/interpro/entry/IPR012001 InterPro IPR012846 http://www.ebi.ac.uk/interpro/entry/IPR012846 InterPro IPR029035 http://www.ebi.ac.uk/interpro/entry/IPR029035 InterPro IPR029061 http://www.ebi.ac.uk/interpro/entry/IPR029061 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0076 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0076 KEGG_Gene eco:b0077 http://www.genome.jp/dbget-bin/www_bget?eco:b0077 KEGG_Orthology KO:K01652 http://www.genome.jp/dbget-bin/www_bget?KO:K01652 KEGG_Pathway ko00290 http://www.genome.jp/kegg-bin/show_pathway?ko00290 KEGG_Pathway ko00650 http://www.genome.jp/kegg-bin/show_pathway?ko00650 KEGG_Pathway ko00660 http://www.genome.jp/kegg-bin/show_pathway?ko00660 KEGG_Pathway ko00770 http://www.genome.jp/kegg-bin/show_pathway?ko00770 KEGG_Reaction rn:R00006 http://www.genome.jp/dbget-bin/www_bget?rn:R00006 KEGG_Reaction rn:R00014 http://www.genome.jp/dbget-bin/www_bget?rn:R00014 KEGG_Reaction rn:R00226 http://www.genome.jp/dbget-bin/www_bget?rn:R00226 KEGG_Reaction rn:R03050 http://www.genome.jp/dbget-bin/www_bget?rn:R03050 KEGG_Reaction rn:R04672 http://www.genome.jp/dbget-bin/www_bget?rn:R04672 KEGG_Reaction rn:R04673 http://www.genome.jp/dbget-bin/www_bget?rn:R04673 OMA MVWPMVP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MVWPMVP PROSITE PS00187 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00187 PSORT swissprot:ILVI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ILVI_ECOLI PSORT-B swissprot:ILVI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ILVI_ECOLI PSORT2 swissprot:ILVI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ILVI_ECOLI Pfam PF00205 http://pfam.xfam.org/family/PF00205 Pfam PF02775 http://pfam.xfam.org/family/PF02775 Pfam PF02776 http://pfam.xfam.org/family/PF02776 Phobius swissprot:ILVI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ILVI_ECOLI PhylomeDB P00893 http://phylomedb.org/?seqid=P00893 ProteinModelPortal P00893 http://www.proteinmodelportal.org/query/uniprot/P00893 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3891724 http://www.ncbi.nlm.nih.gov/pubmed/3891724 PubMed 6308579 http://www.ncbi.nlm.nih.gov/pubmed/6308579 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq WP_001295534 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295534 RefSeq YP_025294 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_025294 SMR P00893 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00893 STRING 511145.b0077 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0077&targetmode=cogs STRING COG0028 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0028&targetmode=cogs SUPFAM SSF52467 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52467 SUPFAM SSF52518 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52518 TIGRFAMs TIGR00118 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00118 UniProtKB ILVI_ECOLI http://www.uniprot.org/uniprot/ILVI_ECOLI UniProtKB-AC P00893 http://www.uniprot.org/uniprot/P00893 charge swissprot:ILVI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ILVI_ECOLI eggNOG COG0028 http://eggnogapi.embl.de/nog_data/html/tree/COG0028 eggNOG ENOG4105C7K http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C7K epestfind swissprot:ILVI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ILVI_ECOLI garnier swissprot:ILVI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ILVI_ECOLI helixturnhelix swissprot:ILVI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ILVI_ECOLI hmoment swissprot:ILVI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ILVI_ECOLI iep swissprot:ILVI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ILVI_ECOLI inforesidue swissprot:ILVI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ILVI_ECOLI octanol swissprot:ILVI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ILVI_ECOLI pepcoil swissprot:ILVI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ILVI_ECOLI pepdigest swissprot:ILVI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ILVI_ECOLI pepinfo swissprot:ILVI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ILVI_ECOLI pepnet swissprot:ILVI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ILVI_ECOLI pepstats swissprot:ILVI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ILVI_ECOLI pepwheel swissprot:ILVI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ILVI_ECOLI pepwindow swissprot:ILVI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ILVI_ECOLI sigcleave swissprot:ILVI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ILVI_ECOLI ## Database ID URL or Descriptions # BioGrid 4259439 31 # DISRUPTION PHENOTYPE Not essential (in strain K12 / BW25113). {ECO:0000269|PubMed 22661687}. # EcoGene EG12743 yqjD # FUNCTION YQJD_ECOLI Upon overexpression inhibits growth. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_component GO:0060187 cell pole; IDA:EcoCyc. # GO_function GO:0043024 ribosomal small subunit binding; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # INDUCTION Maximally expressed after 2 days growth, i.e. during stationary phase (at protein level). Expression is regulated by RpoS. {ECO:0000269|PubMed 22661687}. # InterPro IPR010279 DUF883_ElaB # Organism YQJD_ECOLI Escherichia coli (strain K12) # PATRIC 32121616 VBIEscCol129921_3194 # PIR G65098 G65098 # Pfam PF05957 DUF883 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YQJD_ECOLI Uncharacterized protein YqjD # RefSeq NP_417569 NC_000913.3 # RefSeq WP_000031415 NZ_LN832404.1 # SIMILARITY Belongs to the ElaB/YgaM/YqjD family. {ECO 0000305}. # SUBCELLULAR LOCATION YQJD_ECOLI Cell inner membrane {ECO 0000269|PubMed 22380631, ECO 0000269|PubMed 22661687}; Single-pass membrane protein {ECO 0000269|PubMed 22380631, ECO 0000269|PubMed 22661687}. Note=Predominantly localized to 1 cell pole in stationary phase, with a few smaller foci elsewhere in the cell; polar localization depends on the minCDE operon. # SUBUNIT YQJD_ECOLI Binds to 70S and 100S ribosomes, probably via the 30S subunit. # eggNOG COG4575 LUCA # eggNOG ENOG4105NE1 Bacteria BLAST swissprot:YQJD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YQJD_ECOLI BioCyc ECOL316407:JW3069-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3069-MONOMER BioCyc EcoCyc:G7612-MONOMER http://biocyc.org/getid?id=EcoCyc:G7612-MONOMER DIP DIP-47920N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47920N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2012.08021.x http://dx.doi.org/10.1111/j.1365-2958.2012.08021.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00396-12 http://dx.doi.org/10.1128/JB.00396-12 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2599 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2599 EcoGene EG12743 http://www.ecogene.org/geneInfo.php?eg_id=EG12743 EnsemblBacteria AAC76133 http://www.ensemblgenomes.org/id/AAC76133 EnsemblBacteria AAC76133 http://www.ensemblgenomes.org/id/AAC76133 EnsemblBacteria BAE77148 http://www.ensemblgenomes.org/id/BAE77148 EnsemblBacteria BAE77148 http://www.ensemblgenomes.org/id/BAE77148 EnsemblBacteria BAE77148 http://www.ensemblgenomes.org/id/BAE77148 EnsemblBacteria b3098 http://www.ensemblgenomes.org/id/b3098 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0060187 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060187 GO_function GO:0043024 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043024 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GeneID 947614 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947614 HOGENOM HOG000256775 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000256775&db=HOGENOM6 InParanoid P64581 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P64581 IntAct P64581 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P64581* InterPro IPR010279 http://www.ebi.ac.uk/interpro/entry/IPR010279 KEGG_Gene ecj:JW3069 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3069 KEGG_Gene eco:b3098 http://www.genome.jp/dbget-bin/www_bget?eco:b3098 MINT MINT-1308243 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1308243 OMA NPWKSIG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NPWKSIG PSORT swissprot:YQJD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YQJD_ECOLI PSORT-B swissprot:YQJD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YQJD_ECOLI PSORT2 swissprot:YQJD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YQJD_ECOLI Pfam PF05957 http://pfam.xfam.org/family/PF05957 Phobius swissprot:YQJD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YQJD_ECOLI ProteinModelPortal P64581 http://www.proteinmodelportal.org/query/uniprot/P64581 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22380631 http://www.ncbi.nlm.nih.gov/pubmed/22380631 PubMed 22661687 http://www.ncbi.nlm.nih.gov/pubmed/22661687 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417569 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417569 RefSeq WP_000031415 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000031415 STRING 511145.b3098 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3098&targetmode=cogs UniProtKB YQJD_ECOLI http://www.uniprot.org/uniprot/YQJD_ECOLI UniProtKB-AC P64581 http://www.uniprot.org/uniprot/P64581 charge swissprot:YQJD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YQJD_ECOLI eggNOG COG4575 http://eggnogapi.embl.de/nog_data/html/tree/COG4575 eggNOG ENOG4105NE1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105NE1 epestfind swissprot:YQJD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YQJD_ECOLI garnier swissprot:YQJD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YQJD_ECOLI helixturnhelix swissprot:YQJD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YQJD_ECOLI hmoment swissprot:YQJD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YQJD_ECOLI iep swissprot:YQJD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YQJD_ECOLI inforesidue swissprot:YQJD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YQJD_ECOLI octanol swissprot:YQJD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YQJD_ECOLI pepcoil swissprot:YQJD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YQJD_ECOLI pepdigest swissprot:YQJD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YQJD_ECOLI pepinfo swissprot:YQJD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YQJD_ECOLI pepnet swissprot:YQJD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YQJD_ECOLI pepstats swissprot:YQJD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YQJD_ECOLI pepwheel swissprot:YQJD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YQJD_ECOLI pepwindow swissprot:YQJD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YQJD_ECOLI sigcleave swissprot:YQJD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YQJD_ECOLI ## Database ID URL or Descriptions # BioGrid 4260280 76 # EcoGene EG13963 sufD # FUNCTION SUFD_ECOLI The SufBCD complex acts synergistically with SufE to stimulate the cysteine desulfurase activity of SufS. The SufBCD complex contributes to the assembly or repair of oxygen-labile iron-sulfur clusters under oxidative stress. May facilitate iron uptake from extracellular iron chelators under iron limitation. Required for the stability of the FhuF protein. {ECO 0000269|PubMed 10322040, ECO 0000269|PubMed 12941942}. # GO_process GO:0006979 response to oxidative stress; IMP:EcoCyc. # GO_process GO:0016226 iron-sulfur cluster assembly; IDA:EcoCyc. # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0051186 cofactor metabolic process # INTERACTION SUFD_ECOLI P77522 sufB; NbExp=13; IntAct=EBI-562751, EBI-562758; P77499 sufC; NbExp=8; IntAct=EBI-562751, EBI-561601; # IntAct P77689 8 # InterPro IPR000825 SUF_FeS_clus_asmbl_SufBD # InterPro IPR011542 SUF_FeS_clus_asmbl_SufD # Organism SUFD_ECOLI Escherichia coli (strain K12) # PATRIC 32118668 VBIEscCol129921_1752 # PDB 1VH4 X-ray; 1.75 A; A/B=1-423 # PDB 2ZU0 X-ray; 2.20 A; A/B=1-423 # PDB 5AWF X-ray; 2.96 A; B/F=1-423 # PDB 5AWG X-ray; 4.28 A; B/F=1-423 # PIR A64926 A64926 # Pfam PF01458 UPF0051 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SUFD_ECOLI FeS cluster assembly protein SufD # RefSeq NP_416196 NC_000913.3 # RefSeq WP_000907979 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0051 (ycf24) family. {ECO 0000305}. # SUBUNIT SUFD_ECOLI Part of the SufBCD complex that contains SufB, SufC and SufD. Can form homodimers. {ECO 0000269|PubMed 12941942, ECO 0000269|PubMed 16021622}. # TIGRFAMs TIGR01981 sufD # eggNOG COG0719 LUCA # eggNOG ENOG4105JRK Bacteria BLAST swissprot:SUFD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SUFD_ECOLI BioCyc ECOL316407:JW1671-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1671-MONOMER BioCyc EcoCyc:G6907-MONOMER http://biocyc.org/getid?id=EcoCyc:G6907-MONOMER COG COG0719 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0719 DIP DIP-10940N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10940N DOI 10.1002/prot.20541 http://dx.doi.org/10.1002/prot.20541 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M308004200 http://dx.doi.org/10.1074/jbc.M308004200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3721 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3721 EcoGene EG13963 http://www.ecogene.org/geneInfo.php?eg_id=EG13963 EnsemblBacteria AAC74751 http://www.ensemblgenomes.org/id/AAC74751 EnsemblBacteria AAC74751 http://www.ensemblgenomes.org/id/AAC74751 EnsemblBacteria BAA15456 http://www.ensemblgenomes.org/id/BAA15456 EnsemblBacteria BAA15456 http://www.ensemblgenomes.org/id/BAA15456 EnsemblBacteria BAA15456 http://www.ensemblgenomes.org/id/BAA15456 EnsemblBacteria b1681 http://www.ensemblgenomes.org/id/b1681 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979 GO_process GO:0016226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016226 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GeneID 944878 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944878 HOGENOM HOG000069113 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000069113&db=HOGENOM6 InParanoid P77689 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77689 IntAct P77689 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77689* InterPro IPR000825 http://www.ebi.ac.uk/interpro/entry/IPR000825 InterPro IPR011542 http://www.ebi.ac.uk/interpro/entry/IPR011542 KEGG_Gene ecj:JW1671 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1671 KEGG_Gene eco:b1681 http://www.genome.jp/dbget-bin/www_bget?eco:b1681 KEGG_Orthology KO:K09015 http://www.genome.jp/dbget-bin/www_bget?KO:K09015 MINT MINT-7290848 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-7290848 OMA VLRHHTS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VLRHHTS PDB 1VH4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1VH4 PDB 2ZU0 http://www.ebi.ac.uk/pdbe-srv/view/entry/2ZU0 PDB 5AWF http://www.ebi.ac.uk/pdbe-srv/view/entry/5AWF PDB 5AWG http://www.ebi.ac.uk/pdbe-srv/view/entry/5AWG PDBsum 1VH4 http://www.ebi.ac.uk/pdbsum/1VH4 PDBsum 2ZU0 http://www.ebi.ac.uk/pdbsum/2ZU0 PDBsum 5AWF http://www.ebi.ac.uk/pdbsum/5AWF PDBsum 5AWG http://www.ebi.ac.uk/pdbsum/5AWG PSORT swissprot:SUFD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SUFD_ECOLI PSORT-B swissprot:SUFD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SUFD_ECOLI PSORT2 swissprot:SUFD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SUFD_ECOLI Pfam PF01458 http://pfam.xfam.org/family/PF01458 Phobius swissprot:SUFD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SUFD_ECOLI PhylomeDB P77689 http://phylomedb.org/?seqid=P77689 ProteinModelPortal P77689 http://www.proteinmodelportal.org/query/uniprot/P77689 PubMed 10322040 http://www.ncbi.nlm.nih.gov/pubmed/10322040 PubMed 12941942 http://www.ncbi.nlm.nih.gov/pubmed/12941942 PubMed 16021622 http://www.ncbi.nlm.nih.gov/pubmed/16021622 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416196 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416196 RefSeq WP_000907979 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000907979 SMR P77689 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77689 STRING 511145.b1681 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1681&targetmode=cogs STRING COG0719 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0719&targetmode=cogs TIGRFAMs TIGR01981 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01981 UniProtKB SUFD_ECOLI http://www.uniprot.org/uniprot/SUFD_ECOLI UniProtKB-AC P77689 http://www.uniprot.org/uniprot/P77689 charge swissprot:SUFD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SUFD_ECOLI eggNOG COG0719 http://eggnogapi.embl.de/nog_data/html/tree/COG0719 eggNOG ENOG4105JRK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105JRK epestfind swissprot:SUFD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SUFD_ECOLI garnier swissprot:SUFD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SUFD_ECOLI helixturnhelix swissprot:SUFD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SUFD_ECOLI hmoment swissprot:SUFD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SUFD_ECOLI iep swissprot:SUFD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SUFD_ECOLI inforesidue swissprot:SUFD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SUFD_ECOLI octanol swissprot:SUFD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SUFD_ECOLI pepcoil swissprot:SUFD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SUFD_ECOLI pepdigest swissprot:SUFD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SUFD_ECOLI pepinfo swissprot:SUFD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SUFD_ECOLI pepnet swissprot:SUFD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SUFD_ECOLI pepstats swissprot:SUFD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SUFD_ECOLI pepwheel swissprot:SUFD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SUFD_ECOLI pepwindow swissprot:SUFD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SUFD_ECOLI sigcleave swissprot:SUFD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SUFD_ECOLI ## Database ID URL or Descriptions # BioGrid 4261520 9 # EcoGene EG14079 yfaQ # IntAct P76463 8 # InterPro IPR012338 Beta-lactam/transpept-like # InterPro IPR013693 SpoIID/LytB_N # InterPro IPR018748 DUF2300_secreted # Organism YFAQ_ECOLI Escherichia coli (strain K12) # PATRIC 32119811 VBIEscCol129921_2315 # PIR H64992 H64992 # Pfam PF08486 SpoIID # Pfam PF10062 DUF2300; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFAQ_ECOLI Uncharacterized protein YfaQ # RefSeq NP_416730 NC_000913.3 # RefSeq WP_001104549 NZ_LN832404.1 # SUPFAM SSF56601 SSF56601 # eggNOG COG5445 LUCA # eggNOG ENOG41081SK Bacteria BLAST swissprot:YFAQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFAQ_ECOLI BioCyc ECOL316407:JW2220-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2220-MONOMER BioCyc EcoCyc:G7153-MONOMER http://biocyc.org/getid?id=EcoCyc:G7153-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3832 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3832 EcoGene EG14079 http://www.ecogene.org/geneInfo.php?eg_id=EG14079 EnsemblBacteria AAC75286 http://www.ensemblgenomes.org/id/AAC75286 EnsemblBacteria AAC75286 http://www.ensemblgenomes.org/id/AAC75286 EnsemblBacteria BAE76670 http://www.ensemblgenomes.org/id/BAE76670 EnsemblBacteria BAE76670 http://www.ensemblgenomes.org/id/BAE76670 EnsemblBacteria BAE76670 http://www.ensemblgenomes.org/id/BAE76670 EnsemblBacteria b2226 http://www.ensemblgenomes.org/id/b2226 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946730 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946730 HOGENOM HOG000122334 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122334&db=HOGENOM6 InParanoid P76463 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76463 IntAct P76463 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76463* InterPro IPR012338 http://www.ebi.ac.uk/interpro/entry/IPR012338 InterPro IPR013693 http://www.ebi.ac.uk/interpro/entry/IPR013693 InterPro IPR018748 http://www.ebi.ac.uk/interpro/entry/IPR018748 KEGG_Gene ecj:JW2220 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2220 KEGG_Gene eco:b2226 http://www.genome.jp/dbget-bin/www_bget?eco:b2226 OMA SVWKLFV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SVWKLFV PSORT swissprot:YFAQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFAQ_ECOLI PSORT-B swissprot:YFAQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFAQ_ECOLI PSORT2 swissprot:YFAQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFAQ_ECOLI Pfam PF08486 http://pfam.xfam.org/family/PF08486 Pfam PF10062 http://pfam.xfam.org/family/PF10062 Phobius swissprot:YFAQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFAQ_ECOLI ProteinModelPortal P76463 http://www.proteinmodelportal.org/query/uniprot/P76463 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416730 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416730 RefSeq WP_001104549 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001104549 STRING 511145.b2226 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2226&targetmode=cogs SUPFAM SSF56601 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56601 UniProtKB YFAQ_ECOLI http://www.uniprot.org/uniprot/YFAQ_ECOLI UniProtKB-AC P76463 http://www.uniprot.org/uniprot/P76463 charge swissprot:YFAQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFAQ_ECOLI eggNOG COG5445 http://eggnogapi.embl.de/nog_data/html/tree/COG5445 eggNOG ENOG41081SK http://eggnogapi.embl.de/nog_data/html/tree/ENOG41081SK epestfind swissprot:YFAQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFAQ_ECOLI garnier swissprot:YFAQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFAQ_ECOLI helixturnhelix swissprot:YFAQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFAQ_ECOLI hmoment swissprot:YFAQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFAQ_ECOLI iep swissprot:YFAQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFAQ_ECOLI inforesidue swissprot:YFAQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFAQ_ECOLI octanol swissprot:YFAQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFAQ_ECOLI pepcoil swissprot:YFAQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFAQ_ECOLI pepdigest swissprot:YFAQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFAQ_ECOLI pepinfo swissprot:YFAQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFAQ_ECOLI pepnet swissprot:YFAQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFAQ_ECOLI pepstats swissprot:YFAQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFAQ_ECOLI pepwheel swissprot:YFAQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFAQ_ECOLI pepwindow swissprot:YFAQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFAQ_ECOLI sigcleave swissprot:YFAQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFAQ_ECOLI ## Database ID URL or Descriptions # AltName IAAA_ECOLI Beta-aspartyl-peptidase # AltName IAAA_ECOLI EcAIII # AltName IAAA_ECOLI Isoaspartyl dipeptidase # AltName IAAA_ECOLI Isoaspartyl dipeptidase # BIOPHYSICOCHEMICAL PROPERTIES IAAA_ECOLI Kinetic parameters KM=0.138 mM for beta-L-Asp-L-Leu {ECO 0000269|PubMed 15265041}; KM=3.9 mM for L-Asn {ECO 0000269|PubMed 15265041}; Note=No activity for GlcNAc-Asn, Gly-L-Asn, L-Asp, L-Asn-alpha- amide, L-Gln, aspartylglucosamides alpha- or gamma-aspartyl dipeptides.; # BRENDA 3.4.19 2026 # BRENDA 3.5.1 2026 # BioGrid 4259980 8 # CATALYTIC ACTIVITY IAAA_ECOLI Cleavage of a beta-linked Asp residue from the N-terminus of a polypeptide. # EcoGene EG12407 iaaA # FUNCTION IAAA_ECOLI Degrades proteins damaged by L-isoaspartyl residue formation (also known as beta-Asp residues). Degrades L- isoaspartyl-containing di- and maybe also tripeptides. Also has L- asparaginase activity, although this may not be its principal function. {ECO 0000269|PubMed 11988085}. # FUNCTION IAAA_ECOLI May be involved in glutathione, and possibly other peptide, transport, although these results could also be due to polar effects of disruption. {ECO 0000269|PubMed 11988085}. # GO_function GO:0004067 asparaginase activity; IDA:EcoCyc. # GO_function GO:0008798 beta-aspartyl-peptidase activity; IDA:EcoCyc. # GO_function GO:0016787 hydrolase activity; IDA:EcoliWiki. # GO_process GO:0016540 protein autoprocessing; IMP:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_process GO:0051604 protein maturation # INDUCTION IAAA_ECOLI Repressed by cysteine, an effect that is attributed to CysB. # IntAct P37595 9 # InterPro IPR000246 Peptidase_T2 # InterPro IPR029055 Ntn_hydrolases_N # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # MASS SPECTROMETRY Mass=13852; Method=Electrospray; Range=179-315; Note=Subunit beta.; Evidence={ECO:0000269|PubMed 15265041}; # MASS SPECTROMETRY Mass=17091; Method=Electrospray; Range=2-161; Note=Subunit alpha.; Evidence={ECO:0000269|PubMed 15265041}; # Organism IAAA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10188 PTHR10188 # PATRIC 32116859 VBIEscCol129921_0855 # PDB 1JN9 X-ray; 2.30 A; A/C=2-178, B/D=179-321 # PDB 1K2X X-ray; 1.65 A; A/C=2-178, B/D=179-321 # PDB 1T3M X-ray; 1.65 A; A/C=2-178, B/D=179-321 # PDB 2ZAK X-ray; 2.01 A; A/B=2-321 # PDB 2ZAL X-ray; 1.90 A; A/C=2-161, B/D=179-315 # PDB 3C17 X-ray; 1.95 A; A/B=2-321 # PIR D64820 D64820 # PTM IAAA_ECOLI Autocleaved. Generates the alpha and beta subunits. The N- terminal residue of the beta subunit is thought to be responsible for the nucleophile hydrolase activity. # PTM IAAA_ECOLI Both subunits undergo further processing at their C-termini. The overexpressed alpha subunit seems to consist of residues 2- 161, with an oxidized Met residue and a tightly coordinated Na(+), whereas the overexpressed beta subunit is processed to residue 315 and has 3 oxidized Met residues. Processing of the alpha subunit is inhibited by Zn(2+). # Pfam PF01112 Asparaginase_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName IAAA_ECOLI Isoaspartyl peptidase # RecName IAAA_ECOLI Isoaspartyl peptidase subunit alpha # RecName IAAA_ECOLI Isoaspartyl peptidase subunit alpha # RecName IAAA_ECOLI Isoaspartyl peptidase subunit beta # RefSeq NP_415349 NC_000913.3 # RefSeq WP_000513781 NZ_LN832404.1 # SIMILARITY Belongs to the Ntn-hydrolase family. {ECO 0000305}. # SUBUNIT IAAA_ECOLI Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers. {ECO 0000269|PubMed 11053866, ECO 0000269|PubMed 11988085, ECO 0000269|PubMed 15159592, ECO 0000269|PubMed 15946951}. # SUPFAM SSF56235 SSF56235 # eggNOG COG1446 LUCA # eggNOG ENOG4105D44 Bacteria BLAST swissprot:IAAA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:IAAA_ECOLI BioCyc ECOL316407:JW0812-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0812-MONOMER BioCyc EcoCyc:EG12407-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12407-MONOMER BioCyc MetaCyc:EG12407-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12407-MONOMER COG COG1446 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1446 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M504501200 http://dx.doi.org/10.1074/jbc.M504501200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1107/S0907444900010076 http://dx.doi.org/10.1107/S0907444900010076 DOI 10.1107/S0907444904003403 http://dx.doi.org/10.1107/S0907444904003403 DOI 10.1107/S0907444907068072 http://dx.doi.org/10.1107/S0907444907068072 DOI 10.1111/j.1432-1033.2004.04254.x http://dx.doi.org/10.1111/j.1432-1033.2004.04254.x DOI 10.1111/j.1574-6968.2002.tb11113.x http://dx.doi.org/10.1111/j.1574-6968.2002.tb11113.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.19.5 http://www.genome.jp/dbget-bin/www_bget?EC:3.4.19.5 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M21151 http://www.ebi.ac.uk/ena/data/view/M21151 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.4.19.5 http://enzyme.expasy.org/EC/3.4.19.5 EchoBASE EB2307 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2307 EcoGene EG12407 http://www.ecogene.org/geneInfo.php?eg_id=EG12407 EnsemblBacteria AAC73915 http://www.ensemblgenomes.org/id/AAC73915 EnsemblBacteria AAC73915 http://www.ensemblgenomes.org/id/AAC73915 EnsemblBacteria BAA35516 http://www.ensemblgenomes.org/id/BAA35516 EnsemblBacteria BAA35516 http://www.ensemblgenomes.org/id/BAA35516 EnsemblBacteria BAA35516 http://www.ensemblgenomes.org/id/BAA35516 EnsemblBacteria b0828 http://www.ensemblgenomes.org/id/b0828 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004067 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004067 GO_function GO:0008798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008798 GO_function GO:0016787 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016787 GO_process GO:0016540 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016540 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 GeneID 945456 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945456 HOGENOM HOG000174613 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000174613&db=HOGENOM6 InParanoid P37595 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37595 IntAct P37595 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37595* IntEnz 3.4.19.5 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.19.5 InterPro IPR000246 http://www.ebi.ac.uk/interpro/entry/IPR000246 InterPro IPR029055 http://www.ebi.ac.uk/interpro/entry/IPR029055 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW0812 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0812 KEGG_Gene eco:b0828 http://www.genome.jp/dbget-bin/www_bget?eco:b0828 KEGG_Orthology KO:K13051 http://www.genome.jp/dbget-bin/www_bget?KO:K13051 OMA EVFMRTV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EVFMRTV PANTHER PTHR10188 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10188 PDB 1JN9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1JN9 PDB 1K2X http://www.ebi.ac.uk/pdbe-srv/view/entry/1K2X PDB 1T3M http://www.ebi.ac.uk/pdbe-srv/view/entry/1T3M PDB 2ZAK http://www.ebi.ac.uk/pdbe-srv/view/entry/2ZAK PDB 2ZAL http://www.ebi.ac.uk/pdbe-srv/view/entry/2ZAL PDB 3C17 http://www.ebi.ac.uk/pdbe-srv/view/entry/3C17 PDBsum 1JN9 http://www.ebi.ac.uk/pdbsum/1JN9 PDBsum 1K2X http://www.ebi.ac.uk/pdbsum/1K2X PDBsum 1T3M http://www.ebi.ac.uk/pdbsum/1T3M PDBsum 2ZAK http://www.ebi.ac.uk/pdbsum/2ZAK PDBsum 2ZAL http://www.ebi.ac.uk/pdbsum/2ZAL PDBsum 3C17 http://www.ebi.ac.uk/pdbsum/3C17 PSORT swissprot:IAAA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:IAAA_ECOLI PSORT-B swissprot:IAAA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:IAAA_ECOLI PSORT2 swissprot:IAAA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:IAAA_ECOLI Pfam PF01112 http://pfam.xfam.org/family/PF01112 Phobius swissprot:IAAA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:IAAA_ECOLI PhylomeDB P37595 http://phylomedb.org/?seqid=P37595 ProteinModelPortal P37595 http://www.proteinmodelportal.org/query/uniprot/P37595 PubMed 11053866 http://www.ncbi.nlm.nih.gov/pubmed/11053866 PubMed 11988085 http://www.ncbi.nlm.nih.gov/pubmed/11988085 PubMed 12007658 http://www.ncbi.nlm.nih.gov/pubmed/12007658 PubMed 15159592 http://www.ncbi.nlm.nih.gov/pubmed/15159592 PubMed 15265041 http://www.ncbi.nlm.nih.gov/pubmed/15265041 PubMed 15946951 http://www.ncbi.nlm.nih.gov/pubmed/15946951 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18323626 http://www.ncbi.nlm.nih.gov/pubmed/18323626 PubMed 3045084 http://www.ncbi.nlm.nih.gov/pubmed/3045084 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415349 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415349 RefSeq WP_000513781 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000513781 SMR P37595 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37595 STRING 511145.b0828 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0828&targetmode=cogs STRING COG1446 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1446&targetmode=cogs SUPFAM SSF56235 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56235 UniProtKB IAAA_ECOLI http://www.uniprot.org/uniprot/IAAA_ECOLI UniProtKB-AC P37595 http://www.uniprot.org/uniprot/P37595 charge swissprot:IAAA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:IAAA_ECOLI eggNOG COG1446 http://eggnogapi.embl.de/nog_data/html/tree/COG1446 eggNOG ENOG4105D44 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D44 epestfind swissprot:IAAA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:IAAA_ECOLI garnier swissprot:IAAA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:IAAA_ECOLI helixturnhelix swissprot:IAAA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:IAAA_ECOLI hmoment swissprot:IAAA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:IAAA_ECOLI iep swissprot:IAAA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:IAAA_ECOLI inforesidue swissprot:IAAA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:IAAA_ECOLI octanol swissprot:IAAA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:IAAA_ECOLI pepcoil swissprot:IAAA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:IAAA_ECOLI pepdigest swissprot:IAAA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:IAAA_ECOLI pepinfo swissprot:IAAA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:IAAA_ECOLI pepnet swissprot:IAAA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:IAAA_ECOLI pepstats swissprot:IAAA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:IAAA_ECOLI pepwheel swissprot:IAAA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:IAAA_ECOLI pepwindow swissprot:IAAA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:IAAA_ECOLI sigcleave swissprot:IAAA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:IAAA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261877 11 # EcoGene EG11762 yibF # FUNCTION YIBF_ECOLI Glutathione (GSH) transferase homolog, that might be involved in selenium metabolism. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004364 glutathione transferase activity; IBA:GO_Central. # GO_process GO:0006749 glutathione metabolic process; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.20.1050.10 -; 1. # Gene3D 3.40.30.10 -; 1. # IntAct P0ACA1 2 # InterPro IPR004045 Glutathione_S-Trfase_N # InterPro IPR004046 GST_C # InterPro IPR010987 Glutathione-S-Trfase_C-like # InterPro IPR012336 Thioredoxin-like_fold # Organism YIBF_ECOLI Escherichia coli (strain K12) # PATRIC 32122662 VBIEscCol129921_3708 # PDB 3R2Q X-ray; 1.05 A; A=1-202 # PIR S47813 S47813 # PROSITE PS50404 GST_NTER # PROSITE PS50405 GST_CTER # Pfam PF00043 GST_C # Pfam PF13417 GST_N_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIBF_ECOLI Uncharacterized GST-like protein YibF # RefSeq NP_418049 NC_000913.3 # RefSeq WP_000779792 NZ_LN832404.1 # SIMILARITY Belongs to the GST superfamily. HSP26 family. {ECO 0000305}. # SIMILARITY Contains 1 GST C-terminal domain. {ECO 0000305}. # SIMILARITY Contains 1 GST N-terminal domain. {ECO 0000305}. # SUPFAM SSF47616 SSF47616 # SUPFAM SSF52833 SSF52833 # eggNOG COG0625 LUCA # eggNOG ENOG4108U78 Bacteria BLAST swissprot:YIBF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIBF_ECOLI BioCyc ECOL316407:JW3565-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3565-MONOMER BioCyc EcoCyc:EG11762-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11762-MONOMER DOI 10.1002/prot.10452 http://dx.doi.org/10.1002/prot.10452 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19044 http://www.ebi.ac.uk/ena/data/view/L19044 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U16247 http://www.ebi.ac.uk/ena/data/view/U16247 EchoBASE EB1712 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1712 EcoGene EG11762 http://www.ecogene.org/geneInfo.php?eg_id=EG11762 EnsemblBacteria AAC76616 http://www.ensemblgenomes.org/id/AAC76616 EnsemblBacteria AAC76616 http://www.ensemblgenomes.org/id/AAC76616 EnsemblBacteria BAE77701 http://www.ensemblgenomes.org/id/BAE77701 EnsemblBacteria BAE77701 http://www.ensemblgenomes.org/id/BAE77701 EnsemblBacteria BAE77701 http://www.ensemblgenomes.org/id/BAE77701 EnsemblBacteria b3592 http://www.ensemblgenomes.org/id/b3592 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004364 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004364 GO_process GO:0006749 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006749 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016765 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.20.1050.10 http://www.cathdb.info/version/latest/superfamily/1.20.1050.10 Gene3D 3.40.30.10 http://www.cathdb.info/version/latest/superfamily/3.40.30.10 GeneID 948113 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948113 HOGENOM HOG000125756 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125756&db=HOGENOM6 InParanoid P0ACA1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACA1 IntAct P0ACA1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACA1* InterPro IPR004045 http://www.ebi.ac.uk/interpro/entry/IPR004045 InterPro IPR004046 http://www.ebi.ac.uk/interpro/entry/IPR004046 InterPro IPR010987 http://www.ebi.ac.uk/interpro/entry/IPR010987 InterPro IPR012336 http://www.ebi.ac.uk/interpro/entry/IPR012336 KEGG_Gene ecj:JW3565 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3565 KEGG_Gene eco:b3592 http://www.genome.jp/dbget-bin/www_bget?eco:b3592 OMA ARWRRMT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ARWRRMT PDB 3R2Q http://www.ebi.ac.uk/pdbe-srv/view/entry/3R2Q PDBsum 3R2Q http://www.ebi.ac.uk/pdbsum/3R2Q PROSITE PS50404 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50404 PROSITE PS50405 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50405 PSORT swissprot:YIBF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIBF_ECOLI PSORT-B swissprot:YIBF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIBF_ECOLI PSORT2 swissprot:YIBF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIBF_ECOLI Pfam PF00043 http://pfam.xfam.org/family/PF00043 Pfam PF13417 http://pfam.xfam.org/family/PF13417 Phobius swissprot:YIBF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIBF_ECOLI PhylomeDB P0ACA1 http://phylomedb.org/?seqid=P0ACA1 ProteinModelPortal P0ACA1 http://www.proteinmodelportal.org/query/uniprot/P0ACA1 PubMed 14635120 http://www.ncbi.nlm.nih.gov/pubmed/14635120 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 8387990 http://www.ncbi.nlm.nih.gov/pubmed/8387990 PubMed 8536964 http://www.ncbi.nlm.nih.gov/pubmed/8536964 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418049 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418049 RefSeq WP_000779792 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000779792 SMR P0ACA1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACA1 STRING 511145.b3592 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3592&targetmode=cogs SUPFAM SSF47616 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47616 SUPFAM SSF52833 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52833 UniProtKB YIBF_ECOLI http://www.uniprot.org/uniprot/YIBF_ECOLI UniProtKB-AC P0ACA1 http://www.uniprot.org/uniprot/P0ACA1 charge swissprot:YIBF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIBF_ECOLI eggNOG COG0625 http://eggnogapi.embl.de/nog_data/html/tree/COG0625 eggNOG ENOG4108U78 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108U78 epestfind swissprot:YIBF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIBF_ECOLI garnier swissprot:YIBF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIBF_ECOLI helixturnhelix swissprot:YIBF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIBF_ECOLI hmoment swissprot:YIBF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIBF_ECOLI iep swissprot:YIBF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIBF_ECOLI inforesidue swissprot:YIBF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIBF_ECOLI octanol swissprot:YIBF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIBF_ECOLI pepcoil swissprot:YIBF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIBF_ECOLI pepdigest swissprot:YIBF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIBF_ECOLI pepinfo swissprot:YIBF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIBF_ECOLI pepnet swissprot:YIBF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIBF_ECOLI pepstats swissprot:YIBF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIBF_ECOLI pepwheel swissprot:YIBF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIBF_ECOLI pepwindow swissprot:YIBF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIBF_ECOLI sigcleave swissprot:YIBF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIBF_ECOLI ## Database ID URL or Descriptions # AltName PMRD_ECOLI BasR post-transcriptional activator # AltName PMRD_ECOLI Polymyxin resistance protein PmrD # BioGrid 4260491 9 # CAUTION The PmrD protein from K12 strain (sequence shown) does not interact with phosphorylated BasR protein, and thus does not seem to be involved in polymyxin resistance. {ECO 0000305}. # EcoGene EG12671 pmrD # FUNCTION PMRD_ECOLI Interacts with phosphorylated BasR protein to mediate transcriptional induction of BasR-activated genes to induce polymyxin resistance in some natural isolates. {ECO 0000269|PubMed 15569938}. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GOslim_process GO:0008150 biological_process # INDUCTION By PhoP. {ECO:0000269|PubMed 15569938}. # IntAct P37590 9 # InterPro IPR020146 Sig_transdc_PmrD # Organism PMRD_ECOLI Escherichia coli (strain K12) # PATRIC 32119885 VBIEscCol129921_2352 # PDB 2JSO NMR; -; A=1-88 # PDB 4HN7 X-ray; 2.35 A; A=1-88 # PIR A64997 A64997 # ProDom PD028730 Sig_transdc_PmrD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PMRD_ECOLI Signal transduction protein PmrD # RefSeq NP_416762 NC_000913.3 # RefSeq WP_001295285 NZ_LN832404.1 # SIMILARITY Belongs to the PmrD family. {ECO 0000305}. # eggNOG ENOG4106GZG Bacteria # eggNOG ENOG410Y1Y0 LUCA BLAST swissprot:PMRD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PMRD_ECOLI BioCyc ECOL316407:JW2254-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2254-MONOMER BioCyc EcoCyc:G7172-MONOMER http://biocyc.org/getid?id=EcoCyc:G7172-MONOMER DOI 10.1016/0378-1119(95)00721-0 http://dx.doi.org/10.1016/0378-1119(95)00721-0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0406038101 http://dx.doi.org/10.1073/pnas.0406038101 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL AY725349 http://www.ebi.ac.uk/ena/data/view/AY725349 EMBL AY725350 http://www.ebi.ac.uk/ena/data/view/AY725350 EMBL AY725351 http://www.ebi.ac.uk/ena/data/view/AY725351 EMBL AY725352 http://www.ebi.ac.uk/ena/data/view/AY725352 EMBL AY725353 http://www.ebi.ac.uk/ena/data/view/AY725353 EMBL AY725354 http://www.ebi.ac.uk/ena/data/view/AY725354 EMBL AY725355 http://www.ebi.ac.uk/ena/data/view/AY725355 EMBL AY725356 http://www.ebi.ac.uk/ena/data/view/AY725356 EMBL AY725357 http://www.ebi.ac.uk/ena/data/view/AY725357 EMBL AY725358 http://www.ebi.ac.uk/ena/data/view/AY725358 EMBL AY725359 http://www.ebi.ac.uk/ena/data/view/AY725359 EMBL AY725360 http://www.ebi.ac.uk/ena/data/view/AY725360 EMBL AY725361 http://www.ebi.ac.uk/ena/data/view/AY725361 EMBL AY725362 http://www.ebi.ac.uk/ena/data/view/AY725362 EMBL AY725363 http://www.ebi.ac.uk/ena/data/view/AY725363 EMBL AY725364 http://www.ebi.ac.uk/ena/data/view/AY725364 EMBL AY725365 http://www.ebi.ac.uk/ena/data/view/AY725365 EMBL AY725366 http://www.ebi.ac.uk/ena/data/view/AY725366 EMBL AY725367 http://www.ebi.ac.uk/ena/data/view/AY725367 EMBL AY725368 http://www.ebi.ac.uk/ena/data/view/AY725368 EMBL AY725369 http://www.ebi.ac.uk/ena/data/view/AY725369 EMBL AY725370 http://www.ebi.ac.uk/ena/data/view/AY725370 EMBL AY725371 http://www.ebi.ac.uk/ena/data/view/AY725371 EMBL AY725372 http://www.ebi.ac.uk/ena/data/view/AY725372 EMBL AY725373 http://www.ebi.ac.uk/ena/data/view/AY725373 EMBL AY725374 http://www.ebi.ac.uk/ena/data/view/AY725374 EMBL AY725375 http://www.ebi.ac.uk/ena/data/view/AY725375 EMBL AY725376 http://www.ebi.ac.uk/ena/data/view/AY725376 EMBL AY725377 http://www.ebi.ac.uk/ena/data/view/AY725377 EMBL AY725378 http://www.ebi.ac.uk/ena/data/view/AY725378 EMBL AY725379 http://www.ebi.ac.uk/ena/data/view/AY725379 EMBL AY725380 http://www.ebi.ac.uk/ena/data/view/AY725380 EMBL AY725381 http://www.ebi.ac.uk/ena/data/view/AY725381 EMBL AY725382 http://www.ebi.ac.uk/ena/data/view/AY725382 EMBL AY725383 http://www.ebi.ac.uk/ena/data/view/AY725383 EMBL AY725384 http://www.ebi.ac.uk/ena/data/view/AY725384 EMBL AY725385 http://www.ebi.ac.uk/ena/data/view/AY725385 EMBL AY725386 http://www.ebi.ac.uk/ena/data/view/AY725386 EMBL AY725387 http://www.ebi.ac.uk/ena/data/view/AY725387 EMBL AY725388 http://www.ebi.ac.uk/ena/data/view/AY725388 EMBL AY725389 http://www.ebi.ac.uk/ena/data/view/AY725389 EMBL AY725390 http://www.ebi.ac.uk/ena/data/view/AY725390 EMBL AY725391 http://www.ebi.ac.uk/ena/data/view/AY725391 EMBL AY725392 http://www.ebi.ac.uk/ena/data/view/AY725392 EMBL AY725393 http://www.ebi.ac.uk/ena/data/view/AY725393 EMBL AY725394 http://www.ebi.ac.uk/ena/data/view/AY725394 EMBL AY725395 http://www.ebi.ac.uk/ena/data/view/AY725395 EMBL AY725396 http://www.ebi.ac.uk/ena/data/view/AY725396 EMBL AY725397 http://www.ebi.ac.uk/ena/data/view/AY725397 EMBL AY725398 http://www.ebi.ac.uk/ena/data/view/AY725398 EMBL AY725399 http://www.ebi.ac.uk/ena/data/view/AY725399 EMBL AY725400 http://www.ebi.ac.uk/ena/data/view/AY725400 EMBL AY725401 http://www.ebi.ac.uk/ena/data/view/AY725401 EMBL AY725402 http://www.ebi.ac.uk/ena/data/view/AY725402 EMBL AY725403 http://www.ebi.ac.uk/ena/data/view/AY725403 EMBL AY725404 http://www.ebi.ac.uk/ena/data/view/AY725404 EMBL AY725405 http://www.ebi.ac.uk/ena/data/view/AY725405 EMBL AY725406 http://www.ebi.ac.uk/ena/data/view/AY725406 EMBL AY725407 http://www.ebi.ac.uk/ena/data/view/AY725407 EMBL AY725408 http://www.ebi.ac.uk/ena/data/view/AY725408 EMBL AY725409 http://www.ebi.ac.uk/ena/data/view/AY725409 EMBL AY725410 http://www.ebi.ac.uk/ena/data/view/AY725410 EMBL AY725411 http://www.ebi.ac.uk/ena/data/view/AY725411 EMBL AY725412 http://www.ebi.ac.uk/ena/data/view/AY725412 EMBL AY725413 http://www.ebi.ac.uk/ena/data/view/AY725413 EMBL AY725414 http://www.ebi.ac.uk/ena/data/view/AY725414 EMBL AY725415 http://www.ebi.ac.uk/ena/data/view/AY725415 EMBL AY725416 http://www.ebi.ac.uk/ena/data/view/AY725416 EMBL AY725417 http://www.ebi.ac.uk/ena/data/view/AY725417 EMBL AY725418 http://www.ebi.ac.uk/ena/data/view/AY725418 EMBL AY725419 http://www.ebi.ac.uk/ena/data/view/AY725419 EMBL L35031 http://www.ebi.ac.uk/ena/data/view/L35031 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2537 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2537 EcoGene EG12671 http://www.ecogene.org/geneInfo.php?eg_id=EG12671 EnsemblBacteria AAC75319 http://www.ensemblgenomes.org/id/AAC75319 EnsemblBacteria AAC75319 http://www.ensemblgenomes.org/id/AAC75319 EnsemblBacteria BAA16079 http://www.ensemblgenomes.org/id/BAA16079 EnsemblBacteria BAA16079 http://www.ensemblgenomes.org/id/BAA16079 EnsemblBacteria BAA16079 http://www.ensemblgenomes.org/id/BAA16079 EnsemblBacteria b2259 http://www.ensemblgenomes.org/id/b2259 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 945130 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945130 IntAct P37590 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37590* InterPro IPR020146 http://www.ebi.ac.uk/interpro/entry/IPR020146 KEGG_Gene ecj:JW2254 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2254 KEGG_Gene eco:b2259 http://www.genome.jp/dbget-bin/www_bget?eco:b2259 OMA QDNTMEW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QDNTMEW PDB 2JSO http://www.ebi.ac.uk/pdbe-srv/view/entry/2JSO PDB 4HN7 http://www.ebi.ac.uk/pdbe-srv/view/entry/4HN7 PDBsum 2JSO http://www.ebi.ac.uk/pdbsum/2JSO PDBsum 4HN7 http://www.ebi.ac.uk/pdbsum/4HN7 PSORT swissprot:PMRD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PMRD_ECOLI PSORT-B swissprot:PMRD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PMRD_ECOLI PSORT2 swissprot:PMRD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PMRD_ECOLI Phobius swissprot:PMRD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PMRD_ECOLI ProteinModelPortal P37590 http://www.proteinmodelportal.org/query/uniprot/P37590 PubMed 15569938 http://www.ncbi.nlm.nih.gov/pubmed/15569938 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8626063 http://www.ncbi.nlm.nih.gov/pubmed/8626063 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416762 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416762 RefSeq WP_001295285 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295285 SMR P37590 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37590 STRING 511145.b2259 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2259&targetmode=cogs UniProtKB PMRD_ECOLI http://www.uniprot.org/uniprot/PMRD_ECOLI UniProtKB-AC P37590 http://www.uniprot.org/uniprot/P37590 charge swissprot:PMRD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PMRD_ECOLI eggNOG ENOG4106GZG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106GZG eggNOG ENOG410Y1Y0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y1Y0 epestfind swissprot:PMRD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PMRD_ECOLI garnier swissprot:PMRD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PMRD_ECOLI helixturnhelix swissprot:PMRD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PMRD_ECOLI hmoment swissprot:PMRD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PMRD_ECOLI iep swissprot:PMRD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PMRD_ECOLI inforesidue swissprot:PMRD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PMRD_ECOLI octanol swissprot:PMRD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PMRD_ECOLI pepcoil swissprot:PMRD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PMRD_ECOLI pepdigest swissprot:PMRD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PMRD_ECOLI pepinfo swissprot:PMRD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PMRD_ECOLI pepnet swissprot:PMRD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PMRD_ECOLI pepstats swissprot:PMRD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PMRD_ECOLI pepwheel swissprot:PMRD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PMRD_ECOLI pepwindow swissprot:PMRD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PMRD_ECOLI sigcleave swissprot:PMRD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PMRD_ECOLI ## Database ID URL or Descriptions # AltName HIS5_ECOLI IGP synthase glutamine amidotransferase subunit # AltName HIS5_ECOLI IGP synthase subunit HisH # AltName HIS5_ECOLI ImGP synthase subunit HisH # BIOPHYSICOCHEMICAL PROPERTIES HIS5_ECOLI Kinetic parameters KM=1.5 uM for glutamine {ECO 0000269|PubMed 8494895}; pH dependence Optimum pH is 6-8. {ECO 0000269|PubMed 8494895}; # BRENDA 4.3.1.B2 2026 # BioGrid 4260419 10 # CATALYTIC ACTIVITY 5-[(5-phospho-1-deoxyribulos-1- ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4- carboxamide + L-glutamine = imidazole-glycerol phosphate + 5- aminoimidazol-4-carboxamide ribonucleotide + L-glutamate + H(2)O. {ECO:0000269|PubMed 8494895}. # CDD cd01748 GATase1_IGP_Synthase # EcoGene EG10450 hisH # FUNCTION HIS5_ECOLI IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR. # GO_component GO:0009382 imidazoleglycerol-phosphate synthase complex; IDA:EcoCyc. # GO_function GO:0000107 imidazoleglycerol-phosphate synthase activity; IDA:EcoCyc. # GO_process GO:0000105 histidine biosynthetic process; IDA:EcoCyc. # GO_process GO:0006541 glutamine metabolic process; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.50.880 -; 1. # HAMAP MF_00278 HisH # InterPro IPR010139 Imidazole-glycPsynth_HisH # InterPro IPR017926 GATASE # InterPro IPR029062 Class_I_gatase-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00340 Histidine metabolism # Organism HIS5_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-histidine biosynthesis; L- histidine from 5-phospho-alpha-D-ribose 1-diphosphate step 5/9. # PATRIC 32119381 VBIEscCol129921_2100 # PIR JS0132 XQECHH # PIRSF PIRSF000495 Amidotransf_hisH # PROSITE PS51273 GATASE_TYPE_1 # Pfam PF00117 GATase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HIS5_ECOLI Imidazole glycerol phosphate synthase subunit HisH # RefSeq NP_416527 NC_000913.3 # RefSeq WP_001103560 NZ_LN832404.1 # SIMILARITY Contains 1 glutamine amidotransferase type-1 domain. {ECO 0000305}. # SUBCELLULAR LOCATION HIS5_ECOLI Cytoplasm. # SUBUNIT Heterodimer of HisH and HisF. {ECO:0000269|PubMed 8494895}. # SUPFAM SSF52317 SSF52317 # TIGRFAMs TIGR01855 IMP_synth_hisH # UniPathway UPA00031 UER00010 # eggNOG COG0118 LUCA # eggNOG ENOG4108UJE Bacteria BLAST swissprot:HIS5_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HIS5_ECOLI BioCyc ECOL316407:JW2005-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2005-MONOMER BioCyc EcoCyc:GLUTAMIDOTRANS-MONOMER http://biocyc.org/getid?id=EcoCyc:GLUTAMIDOTRANS-MONOMER BioCyc MetaCyc:GLUTAMIDOTRANS-MONOMER http://biocyc.org/getid?id=MetaCyc:GLUTAMIDOTRANS-MONOMER COG COG0118 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0118 DOI 10.1006/jsbi.2001.4390 http://dx.doi.org/10.1006/jsbi.2001.4390 DOI 10.1016/0022-2836(88)90194-5 http://dx.doi.org/10.1016/0022-2836(88)90194-5 DOI 10.1021/bi00070a029 http://dx.doi.org/10.1021/bi00070a029 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.4.2.- http://www.genome.jp/dbget-bin/www_bget?EC:2.4.2.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X13462 http://www.ebi.ac.uk/ena/data/view/X13462 ENZYME 2.4.2.- http://enzyme.expasy.org/EC/2.4.2.- EchoBASE EB0445 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0445 EcoGene EG10450 http://www.ecogene.org/geneInfo.php?eg_id=EG10450 EnsemblBacteria AAC75084 http://www.ensemblgenomes.org/id/AAC75084 EnsemblBacteria AAC75084 http://www.ensemblgenomes.org/id/AAC75084 EnsemblBacteria BAA15854 http://www.ensemblgenomes.org/id/BAA15854 EnsemblBacteria BAA15854 http://www.ensemblgenomes.org/id/BAA15854 EnsemblBacteria BAA15854 http://www.ensemblgenomes.org/id/BAA15854 EnsemblBacteria b2023 http://www.ensemblgenomes.org/id/b2023 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009382 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009382 GO_function GO:0000107 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000107 GO_process GO:0000105 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000105 GO_process GO:0006541 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006541 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.50.880 http://www.cathdb.info/version/latest/superfamily/3.40.50.880 GeneID 946544 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946544 HAMAP MF_00278 http://hamap.expasy.org/unirule/MF_00278 HOGENOM HOG000025030 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000025030&db=HOGENOM6 InParanoid P60595 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P60595 IntAct P60595 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P60595* IntEnz 2.4.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.2 InterPro IPR010139 http://www.ebi.ac.uk/interpro/entry/IPR010139 InterPro IPR017926 http://www.ebi.ac.uk/interpro/entry/IPR017926 InterPro IPR029062 http://www.ebi.ac.uk/interpro/entry/IPR029062 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2005 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2005 KEGG_Gene eco:b2023 http://www.genome.jp/dbget-bin/www_bget?eco:b2023 KEGG_Orthology KO:K02501 http://www.genome.jp/dbget-bin/www_bget?KO:K02501 KEGG_Pathway ko00340 http://www.genome.jp/kegg-bin/show_pathway?ko00340 KEGG_Reaction rn:R04558 http://www.genome.jp/dbget-bin/www_bget?rn:R04558 OMA GMQMLLT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GMQMLLT PROSITE PS51273 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51273 PSORT swissprot:HIS5_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HIS5_ECOLI PSORT-B swissprot:HIS5_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HIS5_ECOLI PSORT2 swissprot:HIS5_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HIS5_ECOLI Pfam PF00117 http://pfam.xfam.org/family/PF00117 Phobius swissprot:HIS5_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HIS5_ECOLI PhylomeDB P60595 http://phylomedb.org/?seqid=P60595 ProteinModelPortal P60595 http://www.proteinmodelportal.org/query/uniprot/P60595 PubMed 11551184 http://www.ncbi.nlm.nih.gov/pubmed/11551184 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3062174 http://www.ncbi.nlm.nih.gov/pubmed/3062174 PubMed 8494895 http://www.ncbi.nlm.nih.gov/pubmed/8494895 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416527 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416527 RefSeq WP_001103560 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001103560 SMR P60595 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P60595 STRING 511145.b2023 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2023&targetmode=cogs STRING COG0118 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0118&targetmode=cogs SUPFAM SSF52317 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52317 SWISS-2DPAGE P60595 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P60595 TIGRFAMs TIGR01855 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01855 UniProtKB HIS5_ECOLI http://www.uniprot.org/uniprot/HIS5_ECOLI UniProtKB-AC P60595 http://www.uniprot.org/uniprot/P60595 charge swissprot:HIS5_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HIS5_ECOLI eggNOG COG0118 http://eggnogapi.embl.de/nog_data/html/tree/COG0118 eggNOG ENOG4108UJE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UJE epestfind swissprot:HIS5_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HIS5_ECOLI garnier swissprot:HIS5_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HIS5_ECOLI helixturnhelix swissprot:HIS5_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HIS5_ECOLI hmoment swissprot:HIS5_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HIS5_ECOLI iep swissprot:HIS5_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HIS5_ECOLI inforesidue swissprot:HIS5_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HIS5_ECOLI octanol swissprot:HIS5_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HIS5_ECOLI pepcoil swissprot:HIS5_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HIS5_ECOLI pepdigest swissprot:HIS5_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HIS5_ECOLI pepinfo swissprot:HIS5_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HIS5_ECOLI pepnet swissprot:HIS5_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HIS5_ECOLI pepstats swissprot:HIS5_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HIS5_ECOLI pepwheel swissprot:HIS5_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HIS5_ECOLI pepwindow swissprot:HIS5_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HIS5_ECOLI sigcleave swissprot:HIS5_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HIS5_ECOLI ## Database ID URL or Descriptions # AltName LEU1_ECOLI Alpha-IPM synthase # AltName LEU1_ECOLI Alpha-isopropylmalate synthase # BioGrid 4259516 9 # CATALYTIC ACTIVITY LEU1_ECOLI Acetyl-CoA + 3-methyl-2-oxobutanoate + H(2)O = (2S)-2-isopropylmalate + CoA. # EcoGene EG11226 leuA # FUNCTION LEU1_ECOLI Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate). # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003852 2-isopropylmalate synthase activity; IMP:EcoCyc. # GO_function GO:0003985 acetyl-CoA C-acetyltransferase activity; IDA:EcoCyc. # GO_process GO:0009082 branched-chain amino acid biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0009098 leucine biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.20.20.70 -; 1. # HAMAP MF_01025 LeuA_type1 # IntAct P09151 6 # InterPro IPR000891 PYR_CT # InterPro IPR002034 AIPM/Hcit_synth_CS # InterPro IPR005671 LeuA_bact_synth # InterPro IPR013709 2-isopropylmalate_synth_dimer # InterPro IPR013785 Aldolase_TIM # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00290 Valine, leucine and isoleucine biosynthesis # KEGG_Pathway ko00620 Pyruvate metabolism # Organism LEU1_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-leucine biosynthesis; L- leucine from 3-methyl-2-oxobutanoate step 1/4. # PATRIC 32115251 VBIEscCol129921_0077 # PIR B64729 B64729 # PROSITE PS00815 AIPM_HOMOCIT_SYNTH_1 # PROSITE PS00816 AIPM_HOMOCIT_SYNTH_2 # PROSITE PS50991 PYR_CT # Pfam PF00682 HMGL-like # Pfam PF08502 LeuA_dimer # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LEU1_ECOLI 2-isopropylmalate synthase # RefSeq NP_414616 NC_000913.3 # RefSeq WP_000082850 NZ_LN832404.1 # SIMILARITY Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. {ECO 0000305}. # SIMILARITY Contains 1 pyruvate carboxyltransferase domain. {ECO:0000255|PROSITE-ProRule PRU01151}. # SMART SM00917 LeuA_dimer # SUBUNIT LEU1_ECOLI Homotetramer. # SUPFAM SSF110921 SSF110921 # TIGRFAMs TIGR00973 leuA_bact # UniPathway UPA00048 UER00070 # eggNOG COG0119 LUCA # eggNOG ENOG4105CYQ Bacteria BLAST swissprot:LEU1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LEU1_ECOLI BioCyc ECOL316407:JW0073-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0073-MONOMER BioCyc EcoCyc:2-ISOPROPYLMALATESYN-MONOMER http://biocyc.org/getid?id=EcoCyc:2-ISOPROPYLMALATESYN-MONOMER BioCyc MetaCyc:2-ISOPROPYLMALATESYN-MONOMER http://biocyc.org/getid?id=MetaCyc:2-ISOPROPYLMALATESYN-MONOMER COG COG0119 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0119 DIP DIP-6851N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-6851N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1016/0022-2836(81)90348-X http://dx.doi.org/10.1016/0022-2836(81)90348-X DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.3.13 http://www.genome.jp/dbget-bin/www_bget?EC:2.3.3.13 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01642 http://www.ebi.ac.uk/ena/data/view/J01642 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X55034 http://www.ebi.ac.uk/ena/data/view/X55034 ENZYME 2.3.3.13 http://enzyme.expasy.org/EC/2.3.3.13 EchoBASE EB1208 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1208 EcoGene EG11226 http://www.ecogene.org/geneInfo.php?eg_id=EG11226 EnsemblBacteria AAC73185 http://www.ensemblgenomes.org/id/AAC73185 EnsemblBacteria AAC73185 http://www.ensemblgenomes.org/id/AAC73185 EnsemblBacteria BAB96643 http://www.ensemblgenomes.org/id/BAB96643 EnsemblBacteria BAB96643 http://www.ensemblgenomes.org/id/BAB96643 EnsemblBacteria BAB96643 http://www.ensemblgenomes.org/id/BAB96643 EnsemblBacteria b0074 http://www.ensemblgenomes.org/id/b0074 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003852 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003852 GO_function GO:0003985 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003985 GO_process GO:0009082 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009082 GO_process GO:0009098 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009098 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 947465 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947465 HAMAP MF_01025 http://hamap.expasy.org/unirule/MF_01025 HOGENOM HOG000046859 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000046859&db=HOGENOM6 InParanoid P09151 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P09151 IntAct P09151 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P09151* IntEnz 2.3.3.13 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.3.13 InterPro IPR000891 http://www.ebi.ac.uk/interpro/entry/IPR000891 InterPro IPR002034 http://www.ebi.ac.uk/interpro/entry/IPR002034 InterPro IPR005671 http://www.ebi.ac.uk/interpro/entry/IPR005671 InterPro IPR013709 http://www.ebi.ac.uk/interpro/entry/IPR013709 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0073 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0073 KEGG_Gene eco:b0074 http://www.genome.jp/dbget-bin/www_bget?eco:b0074 KEGG_Orthology KO:K01649 http://www.genome.jp/dbget-bin/www_bget?KO:K01649 KEGG_Pathway ko00290 http://www.genome.jp/kegg-bin/show_pathway?ko00290 KEGG_Pathway ko00620 http://www.genome.jp/kegg-bin/show_pathway?ko00620 KEGG_Reaction rn:R01213 http://www.genome.jp/dbget-bin/www_bget?rn:R01213 OMA MAIKTRQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MAIKTRQ PROSITE PS00815 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00815 PROSITE PS00816 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00816 PROSITE PS50991 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50991 PSORT swissprot:LEU1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LEU1_ECOLI PSORT-B swissprot:LEU1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LEU1_ECOLI PSORT2 swissprot:LEU1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LEU1_ECOLI Pfam PF00682 http://pfam.xfam.org/family/PF00682 Pfam PF08502 http://pfam.xfam.org/family/PF08502 Phobius swissprot:LEU1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LEU1_ECOLI PhylomeDB P09151 http://phylomedb.org/?seqid=P09151 ProteinModelPortal P09151 http://www.proteinmodelportal.org/query/uniprot/P09151 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6171647 http://www.ncbi.nlm.nih.gov/pubmed/6171647 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_414616 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414616 RefSeq WP_000082850 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000082850 SMART SM00917 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00917 SMR P09151 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P09151 STRING 511145.b0074 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0074&targetmode=cogs STRING COG0119 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0119&targetmode=cogs SUPFAM SSF110921 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF110921 TIGRFAMs TIGR00973 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00973 UniProtKB LEU1_ECOLI http://www.uniprot.org/uniprot/LEU1_ECOLI UniProtKB-AC P09151 http://www.uniprot.org/uniprot/P09151 charge swissprot:LEU1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LEU1_ECOLI eggNOG COG0119 http://eggnogapi.embl.de/nog_data/html/tree/COG0119 eggNOG ENOG4105CYQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CYQ epestfind swissprot:LEU1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LEU1_ECOLI garnier swissprot:LEU1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LEU1_ECOLI helixturnhelix swissprot:LEU1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LEU1_ECOLI hmoment swissprot:LEU1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LEU1_ECOLI iep swissprot:LEU1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LEU1_ECOLI inforesidue swissprot:LEU1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LEU1_ECOLI octanol swissprot:LEU1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LEU1_ECOLI pepcoil swissprot:LEU1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LEU1_ECOLI pepdigest swissprot:LEU1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LEU1_ECOLI pepinfo swissprot:LEU1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LEU1_ECOLI pepnet swissprot:LEU1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LEU1_ECOLI pepstats swissprot:LEU1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LEU1_ECOLI pepwheel swissprot:LEU1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LEU1_ECOLI pepwindow swissprot:LEU1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LEU1_ECOLI sigcleave swissprot:LEU1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LEU1_ECOLI ## Database ID URL or Descriptions # BRENDA 1.1.1.264 2026 # BioGrid 4259666 722 # CATALYTIC ACTIVITY L-idonate + NAD(P)(+) = 5-dehydrogluconate + NAD(P)H. {ECO:0000269|PubMed 9658018}. # COFACTOR IDND_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000250}; Note=Binds 2 Zn(2+) ions per subunit. {ECO 0000250}; # EcoGene EG12541 idnD # FUNCTION IDND_ECOLI Catalyzes the NADH/NADPH-dependent oxidation of L- idonate to 5-ketogluconate (5KG). {ECO 0000269|PubMed 9658018}. # GO_function GO:0008270 zinc ion binding; IEA:InterPro. # GO_function GO:0050572 L-idonate 5-dehydrogenase activity; IDA:EcoCyc. # GO_process GO:0019521 D-gluconate metabolic process; IEA:UniProtKB-KW. # GO_process GO:0046183 L-idonate catabolic process; IMP:EcoCyc. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.720 -; 1. # Gene3D 3.90.180.10 -; 1. # IntAct P39346 5 # InterPro IPR002085 ADH_SF_Zn-type # InterPro IPR011032 GroES-like # InterPro IPR013149 ADH_C # InterPro IPR013154 ADH_N # InterPro IPR016040 NAD(P)-bd_dom # KEGG_Brite ko01000 Enzymes # Organism IDND_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11695 PTHR11695 # PATHWAY IDND_ECOLI Carbohydrate acid metabolism; L-idonate degradation. # PATRIC 32124107 VBIEscCol129921_4398 # PIR S56493 S56493 # Pfam PF00107 ADH_zinc_N # Pfam PF08240 ADH_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName IDND_ECOLI L-idonate 5-dehydrogenase (NAD(P)(+)) # RefSeq NP_418688 NC_000913.3 # RefSeq WP_001197411 NZ_LN832404.1 # SIMILARITY Belongs to the zinc-containing alcohol dehydrogenase family. {ECO 0000305}. # SUPFAM SSF50129 SSF50129 # SUPFAM SSF51735 SSF51735 # eggNOG COG1063 LUCA # eggNOG ENOG4105CPQ Bacteria BLAST swissprot:IDND_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:IDND_ECOLI BioCyc ECOL316407:JW4224-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4224-MONOMER BioCyc EcoCyc:IDONDEHYD-MONOMER http://biocyc.org/getid?id=EcoCyc:IDONDEHYD-MONOMER BioCyc MetaCyc:IDONDEHYD-MONOMER http://biocyc.org/getid?id=MetaCyc:IDONDEHYD-MONOMER COG COG1063 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1063 DIP DIP-10010N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10010N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.264 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.264 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 1.1.1.264 http://enzyme.expasy.org/EC/1.1.1.264 EchoBASE EB2430 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2430 EcoGene EG12541 http://www.ecogene.org/geneInfo.php?eg_id=EG12541 EnsemblBacteria AAC77224 http://www.ensemblgenomes.org/id/AAC77224 EnsemblBacteria AAC77224 http://www.ensemblgenomes.org/id/AAC77224 EnsemblBacteria BAE78264 http://www.ensemblgenomes.org/id/BAE78264 EnsemblBacteria BAE78264 http://www.ensemblgenomes.org/id/BAE78264 EnsemblBacteria BAE78264 http://www.ensemblgenomes.org/id/BAE78264 EnsemblBacteria b4267 http://www.ensemblgenomes.org/id/b4267 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0050572 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050572 GO_process GO:0019521 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019521 GO_process GO:0046183 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046183 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 Gene3D 3.90.180.10 http://www.cathdb.info/version/latest/superfamily/3.90.180.10 GeneID 944769 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944769 HOGENOM HOG000294670 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000294670&db=HOGENOM6 InParanoid P39346 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39346 IntAct P39346 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39346* IntEnz 1.1.1.264 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.264 InterPro IPR002085 http://www.ebi.ac.uk/interpro/entry/IPR002085 InterPro IPR011032 http://www.ebi.ac.uk/interpro/entry/IPR011032 InterPro IPR013149 http://www.ebi.ac.uk/interpro/entry/IPR013149 InterPro IPR013154 http://www.ebi.ac.uk/interpro/entry/IPR013154 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4224 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4224 KEGG_Gene eco:b4267 http://www.genome.jp/dbget-bin/www_bget?eco:b4267 KEGG_Orthology KO:K00098 http://www.genome.jp/dbget-bin/www_bget?KO:K00098 KEGG_Reaction rn:R05684 http://www.genome.jp/dbget-bin/www_bget?rn:R05684 MINT MINT-1242659 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1242659 OMA AERWQCH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AERWQCH PANTHER PTHR11695 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11695 PSORT swissprot:IDND_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:IDND_ECOLI PSORT-B swissprot:IDND_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:IDND_ECOLI PSORT2 swissprot:IDND_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:IDND_ECOLI Pfam PF00107 http://pfam.xfam.org/family/PF00107 Pfam PF08240 http://pfam.xfam.org/family/PF08240 Phobius swissprot:IDND_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:IDND_ECOLI PhylomeDB P39346 http://phylomedb.org/?seqid=P39346 ProteinModelPortal P39346 http://www.proteinmodelportal.org/query/uniprot/P39346 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9658018 http://www.ncbi.nlm.nih.gov/pubmed/9658018 RefSeq NP_418688 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418688 RefSeq WP_001197411 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001197411 SMR P39346 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39346 STRING 511145.b4267 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4267&targetmode=cogs STRING COG1063 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1063&targetmode=cogs SUPFAM SSF50129 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50129 SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB IDND_ECOLI http://www.uniprot.org/uniprot/IDND_ECOLI UniProtKB-AC P39346 http://www.uniprot.org/uniprot/P39346 charge swissprot:IDND_ECOLI http://rest.g-language.org/emboss/charge/swissprot:IDND_ECOLI eggNOG COG1063 http://eggnogapi.embl.de/nog_data/html/tree/COG1063 eggNOG ENOG4105CPQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CPQ epestfind swissprot:IDND_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:IDND_ECOLI garnier swissprot:IDND_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:IDND_ECOLI helixturnhelix swissprot:IDND_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:IDND_ECOLI hmoment swissprot:IDND_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:IDND_ECOLI iep swissprot:IDND_ECOLI http://rest.g-language.org/emboss/iep/swissprot:IDND_ECOLI inforesidue swissprot:IDND_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:IDND_ECOLI octanol swissprot:IDND_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:IDND_ECOLI pepcoil swissprot:IDND_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:IDND_ECOLI pepdigest swissprot:IDND_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:IDND_ECOLI pepinfo swissprot:IDND_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:IDND_ECOLI pepnet swissprot:IDND_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:IDND_ECOLI pepstats swissprot:IDND_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:IDND_ECOLI pepwheel swissprot:IDND_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:IDND_ECOLI pepwindow swissprot:IDND_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:IDND_ECOLI sigcleave swissprot:IDND_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:IDND_ECOLI ## Database ID URL or Descriptions # AltName SOPA_ECOLI Plasmid partition protein A # FUNCTION SOPA_ECOLI This protein is essential for plasmid partition. It ensures the proper distribution of newly replicated plasmids to daughter cells during cell division. SopA is trans-acting. # GO_process GO:0030541 plasmid partitioning; IEA:UniProtKB-KW. # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.300 -; 1. # InterPro IPR025669 AAA_dom # InterPro IPR027417 P-loop_NTPase # Organism SOPA_ECOLI Escherichia coli (strain K12) # PIR A25783 BVECAF # PIR T00243 T00243 # Pfam PF13614 AAA_31 # RecName SOPA_ECOLI Protein SopA # RefSeq NP_061425 NC_002483.1 # RefSeq WP_000772446 NZ_CP014273.1 # RefSeq YP_001294714 NC_009602.1 # SEQUENCE CAUTION Sequence=AAA24902.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA97916.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ParA family. {ECO 0000305}. # SUPFAM SSF52540 SSF52540 BLAST swissprot:SOPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SOPA_ECOLI DOI 10.1016/0022-2836(86)90459-6 http://dx.doi.org/10.1016/0022-2836(86)90459-6 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL M12987 http://www.ebi.ac.uk/ena/data/view/M12987 EMBL X04619 http://www.ebi.ac.uk/ena/data/view/X04619 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0030541 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030541 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 1263522 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263522 GeneID 5290922 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5290922 InterPro IPR025669 http://www.ebi.ac.uk/interpro/entry/IPR025669 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 OMA ELEVFEF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ELEVFEF PSORT swissprot:SOPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SOPA_ECOLI PSORT-B swissprot:SOPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SOPA_ECOLI PSORT2 swissprot:SOPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SOPA_ECOLI Pfam PF13614 http://pfam.xfam.org/family/PF13614 Phobius swissprot:SOPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SOPA_ECOLI ProteinModelPortal P62556 http://www.proteinmodelportal.org/query/uniprot/P62556 PubMed 3029390 http://www.ncbi.nlm.nih.gov/pubmed/3029390 RefSeq NP_061425 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061425 RefSeq WP_000772446 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000772446 RefSeq YP_001294714 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001294714 SMR P62556 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P62556 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB SOPA_ECOLI http://www.uniprot.org/uniprot/SOPA_ECOLI UniProtKB-AC P62556 http://www.uniprot.org/uniprot/P62556 charge swissprot:SOPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SOPA_ECOLI epestfind swissprot:SOPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SOPA_ECOLI garnier swissprot:SOPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SOPA_ECOLI helixturnhelix swissprot:SOPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SOPA_ECOLI hmoment swissprot:SOPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SOPA_ECOLI iep swissprot:SOPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SOPA_ECOLI inforesidue swissprot:SOPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SOPA_ECOLI octanol swissprot:SOPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SOPA_ECOLI pepcoil swissprot:SOPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SOPA_ECOLI pepdigest swissprot:SOPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SOPA_ECOLI pepinfo swissprot:SOPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SOPA_ECOLI pepnet swissprot:SOPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SOPA_ECOLI pepstats swissprot:SOPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SOPA_ECOLI pepwheel swissprot:SOPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SOPA_ECOLI pepwindow swissprot:SOPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SOPA_ECOLI sigcleave swissprot:SOPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SOPA_ECOLI ## Database ID URL or Descriptions # AltName Fumarase A {ECO:0000303|PubMed 1329945} # AltName Oxaloacetate keto--enol-isomerase {ECO:0000303|PubMed 8422384} # AltName Oxaloacetate tautomerase {ECO:0000305|PubMed 8422384} # BIOPHYSICOCHEMICAL PROPERTIES FUMA_ECOLI Kinetic parameters KM=0.7 mM for (S)-malate {ECO 0000269|PubMed 1329945}; KM=0.7 mM for (S)-malate {ECO 0000269|PubMed 23405168}; KM=0.6 mM for fumarate {ECO 0000269|PubMed 8422384}; KM=0.46 mM for fumarate {ECO 0000269|PubMed 23405168}; KM=0.8 mM for D-tartrate {ECO 0000269|PubMed 23405168}; KM=0.1 mM for enol-oxaloacetate {ECO 0000269|PubMed 8422384}; Vmax=720 umol/min/mg enzyme for (S)-malate dehydration {ECO 0000269|PubMed 23405168}; Vmax=1900 umol/min/mg enzyme for fumarate hydration {ECO 0000269|PubMed 23405168}; Vmax=2.3 umol/min/mg enzyme for D-tartrate dehydration {ECO 0000269|PubMed 23405168}; Note=kcat is 3000 sec(-1) for the hydration of fumarate and 300 sec(-1) for the isomerization of enol-oxaloacetate. {ECO 0000269|PubMed 8422384}; # BioGrid 4263122 8 # CATALYTIC ACTIVITY FUMA_ECOLI (S)-malate = fumarate + H(2)O. {ECO 0000269|PubMed 1329945, ECO 0000269|PubMed 23405168, ECO 0000269|PubMed 8422384}. # CATALYTIC ACTIVITY Keto-oxaloacetate = enol-oxaloacetate. {ECO:0000269|PubMed 8422384}. # COFACTOR FUMA_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000269|PubMed 1329945, ECO 0000269|PubMed 23405168}; Note=Binds 1 [4Fe-4S] cluster per subunit. {ECO 0000269|PubMed 1329945, ECO 0000269|PubMed 23405168}; # ENZYME REGULATION FUMA_ECOLI Is inactivated by oxygen, due to oxidation of the Fe-S cluster to its [3Fe-4S] form. Both the fumarase and the isomerase reactions are competitively inhibited by 3-hydroxy-2- nitropropionate. The isomerase reaction is also inhibited by fumarate and malate. {ECO 0000269|PubMed 1329945, ECO 0000269|PubMed 23405168, ECO 0000269|PubMed 8422384}. # EcoGene EG10356 fumA # FUNCTION FUMA_ECOLI Catalyzes the reversible hydration of fumarate to (S)- malate. Functions as an aerobic enzyme in the direction of malate formation as part of the citric acid cycle. Accounts for about 80% of the fumarase activity when the bacteria grow aerobically. To a lesser extent, also displays D-tartrate dehydratase activity in vitro, but is not able to convert (R)-malate, L-tartrate or meso- tartrate. Can also catalyze the isomerization of enol- to keto- oxaloacetate. {ECO 0000269|PubMed 1329945, ECO 0000269|PubMed 23405168, ECO 0000269|PubMed 3282546, ECO 0000269|PubMed 8422384, ECO 0000269|Ref.7}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0004333 fumarate hydratase activity; IDA:EcoliWiki. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0050163 oxaloacetate tautomerase activity; IDA:EcoCyc. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IDA:EcoCyc. # GO_process GO:0006099 tricarboxylic acid cycle; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.130.10 -; 1. # INDUCTION Is expressed under aerobic conditions. Is repressed by glucose and anaerobiosis. {ECO 0000269|Ref.7}. # INTERACTION FUMA_ECOLI Self; NbExp=2; IntAct=EBI-549075, EBI-549075; # IntAct P0AC33 5 # InterPro IPR004646 Fe-S_hydro-lyase_TtdA-typ_cat # InterPro IPR004647 Fe-S_hydro-lyase_TtdB-typ_cat # InterPro IPR011167 Fe_dep_fumarate_hydratase # InterPro IPR020557 Fumarate_lyase_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00020 Citrate cycle (TCA cycle) # KEGG_Pathway ko00720 Carbon fixation pathways in prokaryotes # Organism FUMA_ECOLI Escherichia coli (strain K12) # PATHWAY FUMA_ECOLI Carbohydrate metabolism; tricarboxylic acid cycle; (S)- malate from fumarate step 1/1. {ECO 0000303|PubMed 1329945, ECO 0000303|PubMed 3282546}. # PATRIC 32118526 VBIEscCol129921_1683 # PIR A03531 UFECAQ # PIRSF PIRSF001394 Fe_dep_fumar_hy # PROSITE PS00163 FUMARATE_LYASES # Pfam PF05681 Fumerase # Pfam PF05683 Fumerase_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Fumarate hydratase class I, aerobic {ECO:0000303|PubMed 3282546} # RefSeq NP_416129 NC_000913.3 # RefSeq WP_000066639 NZ_LN832404.1 # SIMILARITY Belongs to the class-I fumarase family. {ECO 0000305}. # SUBUNIT FUMA_ECOLI Homodimer. {ECO 0000269|PubMed 1329945, ECO 0000269|PubMed 3282546}. # SUPFAM SSF117457 SSF117457 # TIGRFAMs TIGR00722 ttdA_fumA_fumB # TIGRFAMs TIGR00723 ttdB_fumA_fumB # UniPathway UPA00223 UER01007 # eggNOG COG1838 LUCA # eggNOG COG1951 LUCA # eggNOG ENOG4107GFK Bacteria BLAST swissprot:FUMA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FUMA_ECOLI BioCyc ECOL316407:JW1604-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1604-MONOMER BioCyc EcoCyc:FUMA-MONOMER http://biocyc.org/getid?id=EcoCyc:FUMA-MONOMER BioCyc MetaCyc:FUMA-MONOMER http://biocyc.org/getid?id=MetaCyc:FUMA-MONOMER COG COG1838 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1838 COG COG1951 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1951 DIP DIP-36200N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36200N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1021/bi00054a009 http://dx.doi.org/10.1021/bi00054a009 DOI 10.1021/bi00157a022 http://dx.doi.org/10.1021/bi00157a022 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/12.8.3631 http://dx.doi.org/10.1093/nar/12.8.3631 DOI 10.1111/j.1574-6968.1987.tb02545.x http://dx.doi.org/10.1111/j.1574-6968.1987.tb02545.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pone.0055549 http://dx.doi.org/10.1371/journal.pone.0055549 EC_number EC:4.2.1.2 {ECO:0000269|PubMed:1329945, ECO:0000269|PubMed:23405168, ECO:0000269|PubMed:8422384} http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.2 {ECO:0000269|PubMed:1329945, ECO:0000269|PubMed:23405168, ECO:0000269|PubMed:8422384} EC_number EC:5.3.2.2 {ECO:0000269|PubMed:8422384} http://www.genome.jp/dbget-bin/www_bget?EC:5.3.2.2 {ECO:0000269|PubMed:8422384} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X00522 http://www.ebi.ac.uk/ena/data/view/X00522 ENZYME 4.2.1.2 {ECO:0000269|PubMed:1329945, ECO:0000269|PubMed:23405168, ECO:0000269|PubMed:8422384} http://enzyme.expasy.org/EC/4.2.1.2 {ECO:0000269|PubMed:1329945, ECO:0000269|PubMed:23405168, ECO:0000269|PubMed:8422384} ENZYME 5.3.2.2 {ECO:0000269|PubMed:8422384} http://enzyme.expasy.org/EC/5.3.2.2 {ECO:0000269|PubMed:8422384} EchoBASE EB0351 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0351 EcoGene EG10356 http://www.ecogene.org/geneInfo.php?eg_id=EG10356 EnsemblBacteria AAC74684 http://www.ensemblgenomes.org/id/AAC74684 EnsemblBacteria AAC74684 http://www.ensemblgenomes.org/id/AAC74684 EnsemblBacteria BAA15360 http://www.ensemblgenomes.org/id/BAA15360 EnsemblBacteria BAA15360 http://www.ensemblgenomes.org/id/BAA15360 EnsemblBacteria BAA15360 http://www.ensemblgenomes.org/id/BAA15360 EnsemblBacteria b1612 http://www.ensemblgenomes.org/id/b1612 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004333 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004333 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0050163 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050163 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0006099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006099 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.130.10 http://www.cathdb.info/version/latest/superfamily/3.20.130.10 GeneID 946826 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946826 HOGENOM HOG000009338 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009338&db=HOGENOM6 InParanoid P0AC33 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AC33 IntAct P0AC33 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AC33* IntEnz 4.2.1.2 {ECO:0000269|PubMed:1329945, ECO:0000269|PubMed:23405168, ECO:0000269|PubMed:8422384} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.2 {ECO:0000269|PubMed:1329945, ECO:0000269|PubMed:23405168, ECO:0000269|PubMed:8422384} IntEnz 5.3.2.2 {ECO:0000269|PubMed:8422384} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.3.2.2 {ECO:0000269|PubMed:8422384} InterPro IPR004646 http://www.ebi.ac.uk/interpro/entry/IPR004646 InterPro IPR004647 http://www.ebi.ac.uk/interpro/entry/IPR004647 InterPro IPR011167 http://www.ebi.ac.uk/interpro/entry/IPR011167 InterPro IPR020557 http://www.ebi.ac.uk/interpro/entry/IPR020557 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1604 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1604 KEGG_Gene eco:b1612 http://www.genome.jp/dbget-bin/www_bget?eco:b1612 KEGG_Orthology KO:K01676 http://www.genome.jp/dbget-bin/www_bget?KO:K01676 KEGG_Pathway ko00020 http://www.genome.jp/kegg-bin/show_pathway?ko00020 KEGG_Pathway ko00720 http://www.genome.jp/kegg-bin/show_pathway?ko00720 KEGG_Reaction rn:R01082 http://www.genome.jp/dbget-bin/www_bget?rn:R01082 MINT MINT-1310290 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1310290 OMA KNTANNM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KNTANNM PROSITE PS00163 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00163 PSORT swissprot:FUMA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FUMA_ECOLI PSORT-B swissprot:FUMA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FUMA_ECOLI PSORT2 swissprot:FUMA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FUMA_ECOLI Pfam PF05681 http://pfam.xfam.org/family/PF05681 Pfam PF05683 http://pfam.xfam.org/family/PF05683 Phobius swissprot:FUMA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FUMA_ECOLI PhylomeDB P0AC33 http://phylomedb.org/?seqid=P0AC33 ProteinModelPortal P0AC33 http://www.proteinmodelportal.org/query/uniprot/P0AC33 PubMed 1329945 http://www.ncbi.nlm.nih.gov/pubmed/1329945 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1917897 http://www.ncbi.nlm.nih.gov/pubmed/1917897 PubMed 23405168 http://www.ncbi.nlm.nih.gov/pubmed/23405168 PubMed 3282546 http://www.ncbi.nlm.nih.gov/pubmed/3282546 PubMed 6328431 http://www.ncbi.nlm.nih.gov/pubmed/6328431 PubMed 8422384 http://www.ncbi.nlm.nih.gov/pubmed/8422384 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_416129 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416129 RefSeq WP_000066639 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000066639 SMR P0AC33 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AC33 STRING 511145.b1612 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1612&targetmode=cogs STRING COG1838 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1838&targetmode=cogs STRING COG1951 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1951&targetmode=cogs SUPFAM SSF117457 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF117457 TIGRFAMs TIGR00722 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00722 TIGRFAMs TIGR00723 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00723 UniProtKB FUMA_ECOLI http://www.uniprot.org/uniprot/FUMA_ECOLI UniProtKB-AC P0AC33 http://www.uniprot.org/uniprot/P0AC33 charge swissprot:FUMA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FUMA_ECOLI eggNOG COG1838 http://eggnogapi.embl.de/nog_data/html/tree/COG1838 eggNOG COG1951 http://eggnogapi.embl.de/nog_data/html/tree/COG1951 eggNOG ENOG4107GFK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107GFK epestfind swissprot:FUMA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FUMA_ECOLI garnier swissprot:FUMA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FUMA_ECOLI helixturnhelix swissprot:FUMA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FUMA_ECOLI hmoment swissprot:FUMA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FUMA_ECOLI iep swissprot:FUMA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FUMA_ECOLI inforesidue swissprot:FUMA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FUMA_ECOLI octanol swissprot:FUMA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FUMA_ECOLI pepcoil swissprot:FUMA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FUMA_ECOLI pepdigest swissprot:FUMA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FUMA_ECOLI pepinfo swissprot:FUMA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FUMA_ECOLI pepnet swissprot:FUMA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FUMA_ECOLI pepstats swissprot:FUMA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FUMA_ECOLI pepwheel swissprot:FUMA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FUMA_ECOLI pepwindow swissprot:FUMA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FUMA_ECOLI sigcleave swissprot:FUMA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FUMA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262417 12 # CATALYTIC ACTIVITY ATP + propanoate = ADP + propanoyl phosphate. {ECO:0000255|HAMAP-Rule MF_01881}. # COFACTOR TDCD_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_01881}; # EcoGene EG11172 tdcD # FUNCTION TDCD_ECOLI Catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. It can also use acetyl phosphate as phosphate group acceptor. {ECO 0000255|HAMAP-Rule MF_01881, ECO 0000269|PubMed 9484901}. # GO_component GO:0005622 intracellular; IEA:InterPro. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0008776 acetate kinase activity; IDA:EcoCyc. # GO_function GO:0008980 propionate kinase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006567 threonine catabolic process; IDA:EcoCyc. # GO_process GO:0019665 anaerobic amino acid catabolic process; IDA:EcoCyc. # GO_process GO:0070689 L-threonine catabolic process to propionate; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005622 intracellular # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009056 catabolic process # HAMAP MF_00020 Acetate_kinase # HAMAP MF_01881 Propion_kin_subfam1 # IntAct P11868 3 # InterPro IPR000890 Aliphatic_acid_kin_short-chain # InterPro IPR004372 Ac/propionate_kinase # InterPro IPR023865 Aliphatic_acid_kinase_CS # InterPro IPR024917 Propionate_kinase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00640 Propanoate metabolism # Organism TDCD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21060 PTHR21060 # PATHWAY Amino-acid degradation; L-threonine degradation via propanoate pathway; propanoate from L-threonine: step 4/4. {ECO 0000255|HAMAP-Rule:MF_01881}. # PATRIC 32121646 VBIEscCol129921_3209 # PIR H65100 Q3ECTD # PIRSF PIRSF000722 Acetate_prop_kin # PRINTS PR00471 ACETATEKNASE # PROSITE PS01075 ACETATE_KINASE_1 # PROSITE PS01076 ACETATE_KINASE_2 # Pfam PF00871 Acetate_kinase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Propionate kinase {ECO:0000255|HAMAP-Rule MF_01881} # RefSeq NP_417585 NC_000913.3 # RefSeq WP_001295545 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA24663.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAA57919.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=CAA32595.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; # SIMILARITY Belongs to the acetokinase family. TdcD subfamily. {ECO:0000255|HAMAP-Rule MF_01881}. # SUBUNIT Homodimer. {ECO:0000255|HAMAP-Rule MF_01881}. # TIGRFAMs TIGR00016 ackA # UniPathway UPA00052 UER00510 # eggNOG COG0282 LUCA # eggNOG ENOG4105C6H Bacteria BLAST swissprot:TDCD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TDCD_ECOLI BioCyc ECOL316407:JW5806-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5806-MONOMER BioCyc EcoCyc:PROPKIN-MONOMER http://biocyc.org/getid?id=EcoCyc:PROPKIN-MONOMER BioCyc MetaCyc:PROPKIN-MONOMER http://biocyc.org/getid?id=MetaCyc:PROPKIN-MONOMER COG COG0282 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0282 DIP DIP-10971N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10971N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1998.00696.x http://dx.doi.org/10.1046/j.1365-2958.1998.00696.x DOI 10.1093/nar/17.10.3994 http://dx.doi.org/10.1093/nar/17.10.3994 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.2.15 {ECO:0000255|HAMAP-Rule:MF_01881} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.2.15 {ECO:0000255|HAMAP-Rule:MF_01881} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M23638 http://www.ebi.ac.uk/ena/data/view/M23638 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X14430 http://www.ebi.ac.uk/ena/data/view/X14430 ENZYME 2.7.2.15 {ECO:0000255|HAMAP-Rule:MF_01881} http://enzyme.expasy.org/EC/2.7.2.15 {ECO:0000255|HAMAP-Rule:MF_01881} EchoBASE EB1159 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1159 EcoGene EG11172 http://www.ecogene.org/geneInfo.php?eg_id=EG11172 EnsemblBacteria AAC76150 http://www.ensemblgenomes.org/id/AAC76150 EnsemblBacteria AAC76150 http://www.ensemblgenomes.org/id/AAC76150 EnsemblBacteria BAE77164 http://www.ensemblgenomes.org/id/BAE77164 EnsemblBacteria BAE77164 http://www.ensemblgenomes.org/id/BAE77164 EnsemblBacteria BAE77164 http://www.ensemblgenomes.org/id/BAE77164 EnsemblBacteria b3115 http://www.ensemblgenomes.org/id/b3115 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008776 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008776 GO_function GO:0008980 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008980 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006567 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006567 GO_process GO:0019665 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019665 GO_process GO:0070689 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070689 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GeneID 947635 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947635 HAMAP MF_00020 http://hamap.expasy.org/unirule/MF_00020 HAMAP MF_01881 http://hamap.expasy.org/unirule/MF_01881 HOGENOM HOG000288399 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000288399&db=HOGENOM6 InParanoid P11868 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P11868 IntAct P11868 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P11868* IntEnz 2.7.2.15 {ECO:0000255|HAMAP-Rule:MF_01881} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.2.15 {ECO:0000255|HAMAP-Rule:MF_01881} InterPro IPR000890 http://www.ebi.ac.uk/interpro/entry/IPR000890 InterPro IPR004372 http://www.ebi.ac.uk/interpro/entry/IPR004372 InterPro IPR023865 http://www.ebi.ac.uk/interpro/entry/IPR023865 InterPro IPR024917 http://www.ebi.ac.uk/interpro/entry/IPR024917 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5806 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5806 KEGG_Gene eco:b3115 http://www.genome.jp/dbget-bin/www_bget?eco:b3115 KEGG_Orthology KO:K00932 http://www.genome.jp/dbget-bin/www_bget?KO:K00932 KEGG_Pathway ko00640 http://www.genome.jp/kegg-bin/show_pathway?ko00640 KEGG_Reaction rn:R01353 http://www.genome.jp/dbget-bin/www_bget?rn:R01353 MINT MINT-1273849 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1273849 OMA YKFIAGE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YKFIAGE PANTHER PTHR21060 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21060 PRINTS PR00471 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00471 PROSITE PS01075 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01075 PROSITE PS01076 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01076 PSORT swissprot:TDCD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TDCD_ECOLI PSORT-B swissprot:TDCD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TDCD_ECOLI PSORT2 swissprot:TDCD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TDCD_ECOLI Pfam PF00871 http://pfam.xfam.org/family/PF00871 Phobius swissprot:TDCD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TDCD_ECOLI PhylomeDB P11868 http://phylomedb.org/?seqid=P11868 ProteinModelPortal P11868 http://www.proteinmodelportal.org/query/uniprot/P11868 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2660107 http://www.ncbi.nlm.nih.gov/pubmed/2660107 PubMed 3053659 http://www.ncbi.nlm.nih.gov/pubmed/3053659 PubMed 8226682 http://www.ncbi.nlm.nih.gov/pubmed/8226682 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9484901 http://www.ncbi.nlm.nih.gov/pubmed/9484901 RefSeq NP_417585 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417585 RefSeq WP_001295545 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295545 SMR P11868 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P11868 STRING 511145.b3115 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3115&targetmode=cogs STRING COG0282 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0282&targetmode=cogs TIGRFAMs TIGR00016 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00016 UniProtKB TDCD_ECOLI http://www.uniprot.org/uniprot/TDCD_ECOLI UniProtKB-AC P11868 http://www.uniprot.org/uniprot/P11868 charge swissprot:TDCD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TDCD_ECOLI eggNOG COG0282 http://eggnogapi.embl.de/nog_data/html/tree/COG0282 eggNOG ENOG4105C6H http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C6H epestfind swissprot:TDCD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TDCD_ECOLI garnier swissprot:TDCD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TDCD_ECOLI helixturnhelix swissprot:TDCD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TDCD_ECOLI hmoment swissprot:TDCD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TDCD_ECOLI iep swissprot:TDCD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TDCD_ECOLI inforesidue swissprot:TDCD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TDCD_ECOLI octanol swissprot:TDCD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TDCD_ECOLI pepcoil swissprot:TDCD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TDCD_ECOLI pepdigest swissprot:TDCD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TDCD_ECOLI pepinfo swissprot:TDCD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TDCD_ECOLI pepnet swissprot:TDCD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TDCD_ECOLI pepstats swissprot:TDCD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TDCD_ECOLI pepwheel swissprot:TDCD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TDCD_ECOLI pepwindow swissprot:TDCD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TDCD_ECOLI sigcleave swissprot:TDCD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TDCD_ECOLI ## Database ID URL or Descriptions # AltName METH_ECOLI 5-methyltetrahydrofolate--homocysteine methyltransferase # AltName METH_ECOLI Methionine synthase, vitamin-B12-dependent # BRENDA 2.1.1.13 2026 # BioGrid 4263452 15 # CATALYTIC ACTIVITY METH_ECOLI 5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine. # CDD cd02069 methionine_synthase_B12_BD # COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI 29105; Note=Binds 1 zinc ion per subunit.; # COFACTOR Name=methyl(III)cobalamin; Xref=ChEBI:CHEBI 28115; # DOMAIN METH_ECOLI Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L- methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L- methionine and flavodoxin regenerates methylcobalamin. {ECO 0000269|PubMed 9201956}. # EcoGene EG10587 metH # FUNCTION METH_ECOLI Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IMP:EcoCyc. # GO_function GO:0008276 protein methyltransferase activity; IDA:BHF-UCL. # GO_function GO:0008705 methionine synthase activity; IDA:BHF-UCL. # GO_function GO:0008898 S-adenosylmethionine-homocysteine S-methyltransferase activity; IEA:InterPro. # GO_function GO:0031419 cobalamin binding; IDA:BHF-UCL. # GO_process GO:0009086 methionine biosynthetic process; IDA:BHF-UCL. # GO_process GO:0035999 tetrahydrofolate interconversion; IDA:BHF-UCL. # GO_process GO:0050667 homocysteine metabolic process; IDA:BHF-UCL. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008168 methyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 1.10.1240.10 -; 1. # Gene3D 3.10.196.10 -; 1. # Gene3D 3.20.20.20 -; 1. # Gene3D 3.20.20.330 -; 1. # Gene3D 3.40.50.280 -; 1. # IntAct P13009 13 # InterPro IPR000489 Pterin-binding_dom # InterPro IPR003726 HCY_dom # InterPro IPR003759 Cbl-bd_cap # InterPro IPR004223 VitB12-dep_Met_synth_activ_dom # InterPro IPR006158 Cobalamin-bd # InterPro IPR011005 Dihydropteroate_synth-like # InterPro IPR011822 MetH # InterPro IPR033706 Met_synthase_B12-bd # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00270 Cysteine and methionine metabolism # KEGG_Pathway ko00450 Selenocompound metabolism # KEGG_Pathway ko00670 One carbon pool by folate # MISCELLANEOUS METH_ECOLI L-homocysteine is bound via the zinc atom. # Organism METH_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetH route) step 1/1. # PATRIC 32123567 VBIEscCol129921_4132 # PDB 1BMT X-ray; 3.00 A; A/B=651-896 # PDB 1K7Y X-ray; 3.00 A; A=651-1227 # PDB 1K98 X-ray; 3.75 A; A=651-1227 # PDB 1MSK X-ray; 1.80 A; A=897-1227 # PDB 3BUL X-ray; 2.30 A; A=649-1227 # PDB 3IV9 X-ray; 3.25 A; A=649-1227 # PDB 3IVA X-ray; 2.70 A; A=649-1227 # PIR B65209 XYECMH # PIRSF PIRSF000381 MetH # PROSITE PS50970 HCY # PROSITE PS50972 PTERIN_BINDING # PROSITE PS50974 ADOMET_ACTIVATION # PROSITE PS51332 B12_BINDING # PROSITE PS51337 B12_BINDING_NTER # Pfam PF00809 Pterin_bind # Pfam PF02310 B12-binding # Pfam PF02574 S-methyl_trans # Pfam PF02607 B12-binding_2 # Pfam PF02965 Met_synt_B12 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName METH_ECOLI Methionine synthase # RefSeq NP_418443 NC_000913.3 # RefSeq WP_000096011 NZ_LN832404.1 # SIMILARITY Belongs to the vitamin-B12 dependent methionine synthase family. {ECO 0000305}. # SIMILARITY Contains 1 AdoMet activation domain. {ECO:0000255|PROSITE-ProRule PRU00346}. # SIMILARITY Contains 1 B12-binding N-terminal domain. {ECO:0000255|PROSITE-ProRule PRU00667}. # SIMILARITY Contains 1 B12-binding domain. {ECO:0000255|PROSITE- ProRule PRU00666}. # SIMILARITY Contains 1 Hcy-binding domain. {ECO:0000255|PROSITE- ProRule PRU00333}. # SIMILARITY Contains 1 pterin-binding domain. {ECO:0000255|PROSITE-ProRule PRU00334}. # SMART SM01018 B12-binding_2 # SUPFAM SSF47644 SSF47644 # SUPFAM SSF51717 SSF51717 # SUPFAM SSF52242 SSF52242 # SUPFAM SSF56507 SSF56507 # SUPFAM SSF82282 SSF82282 # TIGRFAMs TIGR02082 metH # UniPathway UPA00051 UER00081 # eggNOG COG0646 LUCA # eggNOG COG1410 LUCA # eggNOG ENOG4105C3R Bacteria BLAST swissprot:METH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:METH_ECOLI BioCyc ECOL316407:JW3979-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3979-MONOMER BioCyc EcoCyc:HOMOCYSMETB12-MONOMER http://biocyc.org/getid?id=EcoCyc:HOMOCYSMETB12-MONOMER BioCyc MetaCyc:HOMOCYSMETB12-MONOMER http://biocyc.org/getid?id=MetaCyc:HOMOCYSMETB12-MONOMER COG COG0646 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0646 COG COG1410 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1410 DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0022-2836(92)90940-L http://dx.doi.org/10.1016/0022-2836(92)90940-L DOI 10.1016/0378-1119(90)90490-I http://dx.doi.org/10.1016/0378-1119(90)90490-I DOI 10.1016/S0969-2126(96)00135-9 http://dx.doi.org/10.1016/S0969-2126(96)00135-9 DOI 10.1021/ar0000051 http://dx.doi.org/10.1021/ar0000051 DOI 10.1021/bi00087a004 http://dx.doi.org/10.1021/bi00087a004 DOI 10.1021/bi001711c http://dx.doi.org/10.1021/bi001711c DOI 10.1021/bi952389m http://dx.doi.org/10.1021/bi952389m DOI 10.1021/bi9705164 http://dx.doi.org/10.1021/bi9705164 DOI 10.1021/bi971988l http://dx.doi.org/10.1021/bi971988l DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb738 http://dx.doi.org/10.1038/nsb738 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1126/science.7992050 http://dx.doi.org/10.1126/science.7992050 EC_number EC:2.1.1.13 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.13 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J04975 http://www.ebi.ac.uk/ena/data/view/J04975 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X16584 http://www.ebi.ac.uk/ena/data/view/X16584 ENZYME 2.1.1.13 http://enzyme.expasy.org/EC/2.1.1.13 EchoBASE EB0582 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0582 EcoGene EG10587 http://www.ecogene.org/geneInfo.php?eg_id=EG10587 EnsemblBacteria AAC76989 http://www.ensemblgenomes.org/id/AAC76989 EnsemblBacteria AAC76989 http://www.ensemblgenomes.org/id/AAC76989 EnsemblBacteria BAE78021 http://www.ensemblgenomes.org/id/BAE78021 EnsemblBacteria BAE78021 http://www.ensemblgenomes.org/id/BAE78021 EnsemblBacteria BAE78021 http://www.ensemblgenomes.org/id/BAE78021 EnsemblBacteria b4019 http://www.ensemblgenomes.org/id/b4019 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0008276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008276 GO_function GO:0008705 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008705 GO_function GO:0008898 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008898 GO_function GO:0031419 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031419 GO_process GO:0009086 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009086 GO_process GO:0035999 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035999 GO_process GO:0050667 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050667 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 1.10.1240.10 http://www.cathdb.info/version/latest/superfamily/1.10.1240.10 Gene3D 3.10.196.10 http://www.cathdb.info/version/latest/superfamily/3.10.196.10 Gene3D 3.20.20.20 http://www.cathdb.info/version/latest/superfamily/3.20.20.20 Gene3D 3.20.20.330 http://www.cathdb.info/version/latest/superfamily/3.20.20.330 Gene3D 3.40.50.280 http://www.cathdb.info/version/latest/superfamily/3.40.50.280 GeneID 948522 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948522 HOGENOM HOG000251409 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000251409&db=HOGENOM6 InParanoid P13009 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P13009 IntAct P13009 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P13009* IntEnz 2.1.1.13 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.13 InterPro IPR000489 http://www.ebi.ac.uk/interpro/entry/IPR000489 InterPro IPR003726 http://www.ebi.ac.uk/interpro/entry/IPR003726 InterPro IPR003759 http://www.ebi.ac.uk/interpro/entry/IPR003759 InterPro IPR004223 http://www.ebi.ac.uk/interpro/entry/IPR004223 InterPro IPR006158 http://www.ebi.ac.uk/interpro/entry/IPR006158 InterPro IPR011005 http://www.ebi.ac.uk/interpro/entry/IPR011005 InterPro IPR011822 http://www.ebi.ac.uk/interpro/entry/IPR011822 InterPro IPR033706 http://www.ebi.ac.uk/interpro/entry/IPR033706 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3979 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3979 KEGG_Gene eco:b4019 http://www.genome.jp/dbget-bin/www_bget?eco:b4019 KEGG_Orthology KO:K00548 http://www.genome.jp/dbget-bin/www_bget?KO:K00548 KEGG_Pathway ko00270 http://www.genome.jp/kegg-bin/show_pathway?ko00270 KEGG_Pathway ko00450 http://www.genome.jp/kegg-bin/show_pathway?ko00450 KEGG_Pathway ko00670 http://www.genome.jp/kegg-bin/show_pathway?ko00670 KEGG_Reaction rn:R00946 http://www.genome.jp/dbget-bin/www_bget?rn:R00946 KEGG_Reaction rn:R09365 http://www.genome.jp/dbget-bin/www_bget?rn:R09365 OMA DYNSIMV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DYNSIMV PDB 1BMT http://www.ebi.ac.uk/pdbe-srv/view/entry/1BMT PDB 1K7Y http://www.ebi.ac.uk/pdbe-srv/view/entry/1K7Y PDB 1K98 http://www.ebi.ac.uk/pdbe-srv/view/entry/1K98 PDB 1MSK http://www.ebi.ac.uk/pdbe-srv/view/entry/1MSK PDB 3BUL http://www.ebi.ac.uk/pdbe-srv/view/entry/3BUL PDB 3IV9 http://www.ebi.ac.uk/pdbe-srv/view/entry/3IV9 PDB 3IVA http://www.ebi.ac.uk/pdbe-srv/view/entry/3IVA PDBsum 1BMT http://www.ebi.ac.uk/pdbsum/1BMT PDBsum 1K7Y http://www.ebi.ac.uk/pdbsum/1K7Y PDBsum 1K98 http://www.ebi.ac.uk/pdbsum/1K98 PDBsum 1MSK http://www.ebi.ac.uk/pdbsum/1MSK PDBsum 3BUL http://www.ebi.ac.uk/pdbsum/3BUL PDBsum 3IV9 http://www.ebi.ac.uk/pdbsum/3IV9 PDBsum 3IVA http://www.ebi.ac.uk/pdbsum/3IVA PROSITE PS50970 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50970 PROSITE PS50972 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50972 PROSITE PS50974 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50974 PROSITE PS51332 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51332 PROSITE PS51337 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51337 PSORT swissprot:METH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:METH_ECOLI PSORT-B swissprot:METH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:METH_ECOLI PSORT2 swissprot:METH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:METH_ECOLI Pfam PF00809 http://pfam.xfam.org/family/PF00809 Pfam PF02310 http://pfam.xfam.org/family/PF02310 Pfam PF02574 http://pfam.xfam.org/family/PF02574 Pfam PF02607 http://pfam.xfam.org/family/PF02607 Pfam PF02965 http://pfam.xfam.org/family/PF02965 Phobius swissprot:METH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:METH_ECOLI PhylomeDB P13009 http://phylomedb.org/?seqid=P13009 ProteinModelPortal P13009 http://www.proteinmodelportal.org/query/uniprot/P13009 PubMed 11170420 http://www.ncbi.nlm.nih.gov/pubmed/11170420 PubMed 11513576 http://www.ncbi.nlm.nih.gov/pubmed/11513576 PubMed 11731805 http://www.ncbi.nlm.nih.gov/pubmed/11731805 PubMed 1593636 http://www.ncbi.nlm.nih.gov/pubmed/1593636 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2185137 http://www.ncbi.nlm.nih.gov/pubmed/2185137 PubMed 2668277 http://www.ncbi.nlm.nih.gov/pubmed/2668277 PubMed 7992050 http://www.ncbi.nlm.nih.gov/pubmed/7992050 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 8369296 http://www.ncbi.nlm.nih.gov/pubmed/8369296 PubMed 8652590 http://www.ncbi.nlm.nih.gov/pubmed/8652590 PubMed 8939751 http://www.ncbi.nlm.nih.gov/pubmed/8939751 PubMed 9201956 http://www.ncbi.nlm.nih.gov/pubmed/9201956 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9398304 http://www.ncbi.nlm.nih.gov/pubmed/9398304 RefSeq NP_418443 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418443 RefSeq WP_000096011 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000096011 SMART SM01018 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01018 SMR P13009 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P13009 STRING 511145.b4019 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4019&targetmode=cogs STRING COG0646 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0646&targetmode=cogs STRING COG1410 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1410&targetmode=cogs SUPFAM SSF47644 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47644 SUPFAM SSF51717 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51717 SUPFAM SSF52242 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52242 SUPFAM SSF56507 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56507 SUPFAM SSF82282 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF82282 SWISS-2DPAGE P13009 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P13009 TIGRFAMs TIGR02082 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02082 UniProtKB METH_ECOLI http://www.uniprot.org/uniprot/METH_ECOLI UniProtKB-AC P13009 http://www.uniprot.org/uniprot/P13009 charge swissprot:METH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:METH_ECOLI eggNOG COG0646 http://eggnogapi.embl.de/nog_data/html/tree/COG0646 eggNOG COG1410 http://eggnogapi.embl.de/nog_data/html/tree/COG1410 eggNOG ENOG4105C3R http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C3R epestfind swissprot:METH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:METH_ECOLI garnier swissprot:METH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:METH_ECOLI helixturnhelix swissprot:METH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:METH_ECOLI hmoment swissprot:METH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:METH_ECOLI iep swissprot:METH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:METH_ECOLI inforesidue swissprot:METH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:METH_ECOLI octanol swissprot:METH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:METH_ECOLI pepcoil swissprot:METH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:METH_ECOLI pepdigest swissprot:METH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:METH_ECOLI pepinfo swissprot:METH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:METH_ECOLI pepnet swissprot:METH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:METH_ECOLI pepstats swissprot:METH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:METH_ECOLI pepwheel swissprot:METH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:METH_ECOLI pepwindow swissprot:METH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:METH_ECOLI sigcleave swissprot:METH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:METH_ECOLI ## Database ID URL or Descriptions # BioGrid 4263048 181 # EcoGene EG13945 ydhK # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006810 transport; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006810 transport # IntAct P76186 5 # InterPro IPR006726 PHBA_efflux_AaeB/fusaric-R # Organism YDHK_ECOLI Escherichia coli (strain K12) # PATRIC 32118592 VBIEscCol129921_1716 # PIR G64921 G64921 # Pfam PF04632 FUSC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDHK_ECOLI Uncharacterized transporter YdhK # RefSeq NP_416162 NC_000913.3 # RefSeq WP_000994333 NZ_LN832404.1 # SIMILARITY Belongs to the aromatic acid exporter ArAE (TC 2.A.85) family. {ECO 0000305}. # SUBCELLULAR LOCATION YDHK_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # eggNOG COG1289 LUCA # eggNOG ENOG4105DSW Bacteria BLAST swissprot:YDHK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDHK_ECOLI BioCyc ECOL316407:JW1637-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1637-MONOMER BioCyc EcoCyc:G6885-MONOMER http://biocyc.org/getid?id=EcoCyc:G6885-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3703 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3703 EcoGene EG13945 http://www.ecogene.org/geneInfo.php?eg_id=EG13945 EnsemblBacteria AAC74717 http://www.ensemblgenomes.org/id/AAC74717 EnsemblBacteria AAC74717 http://www.ensemblgenomes.org/id/AAC74717 EnsemblBacteria BAA15405 http://www.ensemblgenomes.org/id/BAA15405 EnsemblBacteria BAA15405 http://www.ensemblgenomes.org/id/BAA15405 EnsemblBacteria BAA15405 http://www.ensemblgenomes.org/id/BAA15405 EnsemblBacteria b1645 http://www.ensemblgenomes.org/id/b1645 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 946528 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946528 HOGENOM HOG000283450 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000283450&db=HOGENOM6 InParanoid P76186 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76186 IntAct P76186 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76186* InterPro IPR006726 http://www.ebi.ac.uk/interpro/entry/IPR006726 KEGG_Gene ecj:JW1637 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1637 KEGG_Gene eco:b1645 http://www.genome.jp/dbget-bin/www_bget?eco:b1645 OMA LCTWACA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LCTWACA PSORT swissprot:YDHK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDHK_ECOLI PSORT-B swissprot:YDHK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDHK_ECOLI PSORT2 swissprot:YDHK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDHK_ECOLI Pfam PF04632 http://pfam.xfam.org/family/PF04632 Phobius swissprot:YDHK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDHK_ECOLI PhylomeDB P76186 http://phylomedb.org/?seqid=P76186 ProteinModelPortal P76186 http://www.proteinmodelportal.org/query/uniprot/P76186 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416162 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416162 RefSeq WP_000994333 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000994333 STRING 511145.b1645 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1645&targetmode=cogs UniProtKB YDHK_ECOLI http://www.uniprot.org/uniprot/YDHK_ECOLI UniProtKB-AC P76186 http://www.uniprot.org/uniprot/P76186 charge swissprot:YDHK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDHK_ECOLI eggNOG COG1289 http://eggnogapi.embl.de/nog_data/html/tree/COG1289 eggNOG ENOG4105DSW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DSW epestfind swissprot:YDHK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDHK_ECOLI garnier swissprot:YDHK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDHK_ECOLI helixturnhelix swissprot:YDHK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDHK_ECOLI hmoment swissprot:YDHK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDHK_ECOLI iep swissprot:YDHK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDHK_ECOLI inforesidue swissprot:YDHK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDHK_ECOLI octanol swissprot:YDHK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDHK_ECOLI pepcoil swissprot:YDHK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDHK_ECOLI pepdigest swissprot:YDHK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDHK_ECOLI pepinfo swissprot:YDHK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDHK_ECOLI pepnet swissprot:YDHK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDHK_ECOLI pepstats swissprot:YDHK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDHK_ECOLI pepwheel swissprot:YDHK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDHK_ECOLI pepwindow swissprot:YDHK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDHK_ECOLI sigcleave swissprot:YDHK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDHK_ECOLI ## Database ID URL or Descriptions # BioGrid 4261084 120 # EcoGene EG12374 yhfG # InterPro IPR022541 DUF2559 # Organism YHFG_ECOLI Escherichia coli (strain K12) # PATRIC 32122158 VBIEscCol129921_3456 # PDB 5JFF X-ray; 2.00 A; B/D=2-55 # PDB 5JFZ X-ray; 2.40 A; B/D/F=2-55 # PIR JV0064 JV0064 # Pfam PF10832 DUF2559 # ProDom PD026929 PD026929 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHFG_ECOLI Uncharacterized protein YhfG # RefSeq NP_417821 NC_000913.3 # RefSeq WP_000736862 NZ_LN832404.1 BLAST swissprot:YHFG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHFG_ECOLI BioCyc ECOL316407:JW3325-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3325-MONOMER BioCyc EcoCyc:EG12374-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12374-MONOMER DIP DIP-48177N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48177N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M28363 http://www.ebi.ac.uk/ena/data/view/M28363 EMBL M32354 http://www.ebi.ac.uk/ena/data/view/M32354 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2277 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2277 EcoGene EG12374 http://www.ecogene.org/geneInfo.php?eg_id=EG12374 EnsemblBacteria AAC76387 http://www.ensemblgenomes.org/id/AAC76387 EnsemblBacteria AAC76387 http://www.ensemblgenomes.org/id/AAC76387 EnsemblBacteria BAE77928 http://www.ensemblgenomes.org/id/BAE77928 EnsemblBacteria BAE77928 http://www.ensemblgenomes.org/id/BAE77928 EnsemblBacteria BAE77928 http://www.ensemblgenomes.org/id/BAE77928 EnsemblBacteria b3362 http://www.ensemblgenomes.org/id/b3362 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947871 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947871 HOGENOM HOG000294579 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000294579&db=HOGENOM6 IntAct P0ADX5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADX5* InterPro IPR022541 http://www.ebi.ac.uk/interpro/entry/IPR022541 KEGG_Gene ecj:JW3325 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3325 KEGG_Gene eco:b3362 http://www.genome.jp/dbget-bin/www_bget?eco:b3362 PDB 5JFF http://www.ebi.ac.uk/pdbe-srv/view/entry/5JFF PDB 5JFZ http://www.ebi.ac.uk/pdbe-srv/view/entry/5JFZ PDBsum 5JFF http://www.ebi.ac.uk/pdbsum/5JFF PDBsum 5JFZ http://www.ebi.ac.uk/pdbsum/5JFZ PSORT swissprot:YHFG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHFG_ECOLI PSORT-B swissprot:YHFG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHFG_ECOLI PSORT2 swissprot:YHFG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHFG_ECOLI Pfam PF10832 http://pfam.xfam.org/family/PF10832 Phobius swissprot:YHFG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHFG_ECOLI ProteinModelPortal P0ADX5 http://www.proteinmodelportal.org/query/uniprot/P0ADX5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2403545 http://www.ncbi.nlm.nih.gov/pubmed/2403545 PubMed 2546924 http://www.ncbi.nlm.nih.gov/pubmed/2546924 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417821 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417821 RefSeq WP_000736862 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000736862 STRING 511145.b3362 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3362&targetmode=cogs UniProtKB YHFG_ECOLI http://www.uniprot.org/uniprot/YHFG_ECOLI UniProtKB-AC P0ADX5 http://www.uniprot.org/uniprot/P0ADX5 charge swissprot:YHFG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHFG_ECOLI epestfind swissprot:YHFG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHFG_ECOLI garnier swissprot:YHFG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHFG_ECOLI helixturnhelix swissprot:YHFG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHFG_ECOLI hmoment swissprot:YHFG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHFG_ECOLI iep swissprot:YHFG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHFG_ECOLI inforesidue swissprot:YHFG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHFG_ECOLI octanol swissprot:YHFG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHFG_ECOLI pepcoil swissprot:YHFG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHFG_ECOLI pepdigest swissprot:YHFG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHFG_ECOLI pepinfo swissprot:YHFG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHFG_ECOLI pepnet swissprot:YHFG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHFG_ECOLI pepstats swissprot:YHFG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHFG_ECOLI pepwheel swissprot:YHFG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHFG_ECOLI pepwindow swissprot:YHFG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHFG_ECOLI sigcleave swissprot:YHFG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHFG_ECOLI ## Database ID URL or Descriptions # AltName FLGG_ECOLI Distal rod protein # BioGrid 4261898 6 # EcoGene EG14271 flgG # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_component GO:0009424 bacterial-type flagellum hook; IBA:GO_Central. # GO_component GO:0009426 bacterial-type flagellum basal body, distal rod; IEA:InterPro. # GO_process GO:0071973 bacterial-type flagellum-dependent cell motility; IMP:EcoCyc. # GO_process GO:0071978 bacterial-type flagellum-dependent swarming motility; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0048870 cell motility # IntAct P0ABX5 8 # InterPro IPR001444 Flag_bb_rod_N # InterPro IPR010930 Flg_bb/hook_C_dom # InterPro IPR012834 FlgG_G_neg # InterPro IPR019776 Flagellar_basal_body_rod_CS # InterPro IPR020013 Flagellar_FlgE/F/G # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Pathway ko02040 Flagellar assembly # Organism FLGG_ECOLI Escherichia coli (strain K12) # PATRIC 32117397 VBIEscCol129921_1121 # PIR C64851 C64851 # PROSITE PS00588 FLAGELLA_BB_ROD # Pfam PF00460 Flg_bb_rod # Pfam PF06429 Flg_bbr_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FLGG_ECOLI Flagellar basal-body rod protein FlgG # RefSeq NP_415596 NC_000913.3 # RefSeq WP_000625837 NZ_LN832404.1 # SIMILARITY Belongs to the flagella basal body rod proteins family. {ECO 0000305}. # SUBCELLULAR LOCATION FLGG_ECOLI Bacterial flagellum basal body. # SUBUNIT FLGG_ECOLI The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each. # TIGRFAMs TIGR02488 flgG_G_neg # TIGRFAMs TIGR03506 FlgEFG_subfam; 2 # eggNOG COG4786 LUCA # eggNOG ENOG4105CGA Bacteria BLAST swissprot:FLGG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLGG_ECOLI BioCyc ECOL316407:JW1065-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1065-MONOMER BioCyc EcoCyc:FLGG-FLAGELLAR-MOTOR-ROD-PROTEIN http://biocyc.org/getid?id=EcoCyc:FLGG-FLAGELLAR-MOTOR-ROD-PROTEIN COG COG1749 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1749 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4019 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4019 EcoGene EG14271 http://www.ecogene.org/geneInfo.php?eg_id=EG14271 EnsemblBacteria AAC74162 http://www.ensemblgenomes.org/id/AAC74162 EnsemblBacteria AAC74162 http://www.ensemblgenomes.org/id/AAC74162 EnsemblBacteria BAA35887 http://www.ensemblgenomes.org/id/BAA35887 EnsemblBacteria BAA35887 http://www.ensemblgenomes.org/id/BAA35887 EnsemblBacteria BAA35887 http://www.ensemblgenomes.org/id/BAA35887 EnsemblBacteria b1078 http://www.ensemblgenomes.org/id/b1078 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0009424 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009424 GO_component GO:0009426 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009426 GO_process GO:0071973 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071973 GO_process GO:0071978 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071978 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 GeneID 945647 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945647 HOGENOM HOG000254240 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000254240&db=HOGENOM6 InParanoid P0ABX5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABX5 IntAct P0ABX5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABX5* InterPro IPR001444 http://www.ebi.ac.uk/interpro/entry/IPR001444 InterPro IPR010930 http://www.ebi.ac.uk/interpro/entry/IPR010930 InterPro IPR012834 http://www.ebi.ac.uk/interpro/entry/IPR012834 InterPro IPR019776 http://www.ebi.ac.uk/interpro/entry/IPR019776 InterPro IPR020013 http://www.ebi.ac.uk/interpro/entry/IPR020013 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW1065 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1065 KEGG_Gene eco:b1078 http://www.genome.jp/dbget-bin/www_bget?eco:b1078 KEGG_Orthology KO:K02392 http://www.genome.jp/dbget-bin/www_bget?KO:K02392 KEGG_Pathway ko02040 http://www.genome.jp/kegg-bin/show_pathway?ko02040 OMA QGNGFFQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QGNGFFQ PROSITE PS00588 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00588 PSORT swissprot:FLGG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLGG_ECOLI PSORT-B swissprot:FLGG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLGG_ECOLI PSORT2 swissprot:FLGG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLGG_ECOLI Pfam PF00460 http://pfam.xfam.org/family/PF00460 Pfam PF06429 http://pfam.xfam.org/family/PF06429 Phobius swissprot:FLGG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLGG_ECOLI PhylomeDB P0ABX5 http://phylomedb.org/?seqid=P0ABX5 ProteinModelPortal P0ABX5 http://www.proteinmodelportal.org/query/uniprot/P0ABX5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415596 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415596 RefSeq WP_000625837 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000625837 SMR P0ABX5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABX5 STRING 511145.b1078 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1078&targetmode=cogs STRING COG1749 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1749&targetmode=cogs TIGRFAMs TIGR02488 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02488 TIGRFAMs TIGR03506 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03506 UniProtKB FLGG_ECOLI http://www.uniprot.org/uniprot/FLGG_ECOLI UniProtKB-AC P0ABX5 http://www.uniprot.org/uniprot/P0ABX5 charge swissprot:FLGG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLGG_ECOLI eggNOG COG4786 http://eggnogapi.embl.de/nog_data/html/tree/COG4786 eggNOG ENOG4105CGA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CGA epestfind swissprot:FLGG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLGG_ECOLI garnier swissprot:FLGG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLGG_ECOLI helixturnhelix swissprot:FLGG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLGG_ECOLI hmoment swissprot:FLGG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLGG_ECOLI iep swissprot:FLGG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLGG_ECOLI inforesidue swissprot:FLGG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLGG_ECOLI octanol swissprot:FLGG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLGG_ECOLI pepcoil swissprot:FLGG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLGG_ECOLI pepdigest swissprot:FLGG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLGG_ECOLI pepinfo swissprot:FLGG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLGG_ECOLI pepnet swissprot:FLGG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLGG_ECOLI pepstats swissprot:FLGG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLGG_ECOLI pepwheel swissprot:FLGG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLGG_ECOLI pepwindow swissprot:FLGG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLGG_ECOLI sigcleave swissprot:FLGG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLGG_ECOLI ## Database ID URL or Descriptions # AltName FUMC_ECOLI Iron-independent fumarase # BIOPHYSICOCHEMICAL PROPERTIES FUMC_ECOLI Kinetic parameters KM=50 uM for L-malate (at pH 7.3 and 30 degrees Celsius) {ECO 0000269|PubMed 1917897}; pH dependence Optimum pH is 8. {ECO 0000269|PubMed 1917897}; # BRENDA 4.2.1 2026 # BioGrid 4263123 8 # CATALYTIC ACTIVITY (S)-malate = fumarate + H(2)O. {ECO:0000269|PubMed 1917897}. # ENZYME REGULATION Inhibited by ATP and S-2,3-dicarboxyaziridine. {ECO:0000269|PubMed 1917897}. # EcoGene EG10358 fumC # FUNCTION FUMC_ECOLI Catalyzes the reversible addition of water to fumarate to give L-malate. {ECO 0000269|PubMed 1917897}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_component GO:0045239 tricarboxylic acid cycle enzyme complex; IEA:InterPro. # GO_function GO:0004333 fumarate hydratase activity; IDA:EcoCyc. # GO_process GO:0006099 tricarboxylic acid cycle; IBA:GO_Central. # GO_process GO:0006106 fumarate metabolic process; IBA:GO_Central. # GO_process GO:0006108 malate metabolic process; IBA:GO_Central. # GO_process GO:0006979 response to oxidative stress; IEP:EcoCyc. # GO_process GO:0051262 protein tetramerization; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0006950 response to stress # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.275.10 -; 1. # HAMAP MF_00743 FumaraseC # INDUCTION Under conditions of iron limitation and oxidative stress. {ECO:0000269|PubMed 7592392}. # IntAct P05042 14 # InterPro IPR000362 Fumarate_lyase_fam # InterPro IPR005677 Fum_hydII # InterPro IPR008948 L-Aspartase-like # InterPro IPR018951 Fumarase_C_C # InterPro IPR020557 Fumarate_lyase_CS # InterPro IPR022761 Fumarate_lyase_N # InterPro IPR024083 Fumarase/histidase_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00020 Citrate cycle (TCA cycle) # KEGG_Pathway ko00720 Carbon fixation pathways in prokaryotes # KEGG_Pathway ko05200 Pathways in cancer # KEGG_Pathway ko05211 Renal cell carcinoma # MISCELLANEOUS There are 2 substrate-binding sites the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors. # Organism FUMC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11444 PTHR11444 # PATHWAY Carbohydrate metabolism; tricarboxylic acid cycle; (S)- malate from fumarate step 1/1. # PATRIC 32118524 VBIEscCol129921_1682 # PDB 1FUO X-ray; 1.98 A; A/B=1-467 # PDB 1FUP X-ray; 2.30 A; A/B=1-467 # PDB 1FUQ X-ray; 2.00 A; A/B=1-467 # PDB 1FUR X-ray; 1.95 A; A/B=1-467 # PDB 1KQ7 X-ray; 2.60 A; A/B=1-467 # PDB 1YFE X-ray; 2.19 A; A=1-467 # PDB 2FUS X-ray; 2.20 A; A/B=1-467 # PIR S07138 UFEC # PRINTS PR00149 FUMRATELYASE # PROSITE PS00163 FUMARATE_LYASES # Pfam PF00206 Lyase_1 # Pfam PF10415 FumaraseC_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FUMC_ECOLI Fumarate hydratase class II # RefSeq NP_416128 NC_000913.3 # RefSeq WP_001099085 NZ_LN832404.1 # SIMILARITY Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION FUMC_ECOLI Cytoplasm. # SUBUNIT FUMC_ECOLI Homotetramer. {ECO 0000269|PubMed 12021453, ECO 0000269|PubMed 1917897, ECO 0000269|PubMed 3282546, ECO 0000269|PubMed 8496960, ECO 0000269|PubMed 8909293, ECO 0000269|PubMed 9098893}. # SUPFAM SSF48557 SSF48557 # TIGRFAMs TIGR00979 fumC_II # UniPathway UPA00223 UER01007 # eggNOG COG0114 LUCA # eggNOG ENOG4105C9Q Bacteria BLAST swissprot:FUMC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FUMC_ECOLI BioCyc ECOL316407:JW1603-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1603-MONOMER BioCyc EcoCyc:FUMC-MONOMER http://biocyc.org/getid?id=EcoCyc:FUMC-MONOMER BioCyc MetaCyc:FUMC-MONOMER http://biocyc.org/getid?id=MetaCyc:FUMC-MONOMER COG COG0114 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0114 DIP DIP-9719N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9719N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/pro.5560060410 http://dx.doi.org/10.1002/pro.5560060410 DOI 10.1006/jmbi.1993.1264 http://dx.doi.org/10.1006/jmbi.1993.1264 DOI 10.1021/bi300430j http://dx.doi.org/10.1021/bi300430j DOI 10.1021/bi9614702 http://dx.doi.org/10.1021/bi9614702 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2370547 http://dx.doi.org/10.1042/bj2370547 DOI 10.1073/pnas.0307524101 http://dx.doi.org/10.1073/pnas.0307524101 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/12.8.3631 http://dx.doi.org/10.1093/nar/12.8.3631 DOI 10.1099/00221287-131-11-2971 http://dx.doi.org/10.1099/00221287-131-11-2971 DOI 10.1107/S0907444905024194 http://dx.doi.org/10.1107/S0907444905024194 DOI 10.1110/ps.0201502 http://dx.doi.org/10.1110/ps.0201502 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.1.2 http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X00522 http://www.ebi.ac.uk/ena/data/view/X00522 EMBL X04065 http://www.ebi.ac.uk/ena/data/view/X04065 ENZYME 4.2.1.2 http://enzyme.expasy.org/EC/4.2.1.2 EchoBASE EB0353 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0353 EcoGene EG10358 http://www.ecogene.org/geneInfo.php?eg_id=EG10358 EnsemblBacteria AAC74683 http://www.ensemblgenomes.org/id/AAC74683 EnsemblBacteria AAC74683 http://www.ensemblgenomes.org/id/AAC74683 EnsemblBacteria BAA15349 http://www.ensemblgenomes.org/id/BAA15349 EnsemblBacteria BAA15349 http://www.ensemblgenomes.org/id/BAA15349 EnsemblBacteria BAA15349 http://www.ensemblgenomes.org/id/BAA15349 EnsemblBacteria b1611 http://www.ensemblgenomes.org/id/b1611 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0045239 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045239 GO_function GO:0004333 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004333 GO_process GO:0006099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006099 GO_process GO:0006106 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006106 GO_process GO:0006108 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006108 GO_process GO:0006979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979 GO_process GO:0051262 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051262 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.275.10 http://www.cathdb.info/version/latest/superfamily/1.10.275.10 GeneID 946147 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946147 HAMAP MF_00743 http://hamap.expasy.org/unirule/MF_00743 HOGENOM HOG000061736 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000061736&db=HOGENOM6 InParanoid P05042 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P05042 IntAct P05042 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P05042* IntEnz 4.2.1.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.2 InterPro IPR000362 http://www.ebi.ac.uk/interpro/entry/IPR000362 InterPro IPR005677 http://www.ebi.ac.uk/interpro/entry/IPR005677 InterPro IPR008948 http://www.ebi.ac.uk/interpro/entry/IPR008948 InterPro IPR018951 http://www.ebi.ac.uk/interpro/entry/IPR018951 InterPro IPR020557 http://www.ebi.ac.uk/interpro/entry/IPR020557 InterPro IPR022761 http://www.ebi.ac.uk/interpro/entry/IPR022761 InterPro IPR024083 http://www.ebi.ac.uk/interpro/entry/IPR024083 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1603 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1603 KEGG_Gene eco:b1611 http://www.genome.jp/dbget-bin/www_bget?eco:b1611 KEGG_Orthology KO:K01679 http://www.genome.jp/dbget-bin/www_bget?KO:K01679 KEGG_Pathway ko00020 http://www.genome.jp/kegg-bin/show_pathway?ko00020 KEGG_Pathway ko00720 http://www.genome.jp/kegg-bin/show_pathway?ko00720 KEGG_Pathway ko05200 http://www.genome.jp/kegg-bin/show_pathway?ko05200 KEGG_Pathway ko05211 http://www.genome.jp/kegg-bin/show_pathway?ko05211 KEGG_Reaction rn:R01082 http://www.genome.jp/dbget-bin/www_bget?rn:R01082 OMA FAYLKKA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FAYLKKA PANTHER PTHR11444 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11444 PDB 1FUO http://www.ebi.ac.uk/pdbe-srv/view/entry/1FUO PDB 1FUP http://www.ebi.ac.uk/pdbe-srv/view/entry/1FUP PDB 1FUQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1FUQ PDB 1FUR http://www.ebi.ac.uk/pdbe-srv/view/entry/1FUR PDB 1KQ7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1KQ7 PDB 1YFE http://www.ebi.ac.uk/pdbe-srv/view/entry/1YFE PDB 2FUS http://www.ebi.ac.uk/pdbe-srv/view/entry/2FUS PDBsum 1FUO http://www.ebi.ac.uk/pdbsum/1FUO PDBsum 1FUP http://www.ebi.ac.uk/pdbsum/1FUP PDBsum 1FUQ http://www.ebi.ac.uk/pdbsum/1FUQ PDBsum 1FUR http://www.ebi.ac.uk/pdbsum/1FUR PDBsum 1KQ7 http://www.ebi.ac.uk/pdbsum/1KQ7 PDBsum 1YFE http://www.ebi.ac.uk/pdbsum/1YFE PDBsum 2FUS http://www.ebi.ac.uk/pdbsum/2FUS PRINTS PR00149 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00149 PROSITE PS00163 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00163 PSORT swissprot:FUMC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FUMC_ECOLI PSORT-B swissprot:FUMC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FUMC_ECOLI PSORT2 swissprot:FUMC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FUMC_ECOLI Pfam PF00206 http://pfam.xfam.org/family/PF00206 Pfam PF10415 http://pfam.xfam.org/family/PF10415 Phobius swissprot:FUMC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FUMC_ECOLI PhylomeDB P05042 http://phylomedb.org/?seqid=P05042 ProteinModelPortal P05042 http://www.proteinmodelportal.org/query/uniprot/P05042 PubMed 12021453 http://www.ncbi.nlm.nih.gov/pubmed/12021453 PubMed 14990798 http://www.ncbi.nlm.nih.gov/pubmed/14990798 PubMed 16204892 http://www.ncbi.nlm.nih.gov/pubmed/16204892 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1917897 http://www.ncbi.nlm.nih.gov/pubmed/1917897 PubMed 22551392 http://www.ncbi.nlm.nih.gov/pubmed/22551392 PubMed 3005475 http://www.ncbi.nlm.nih.gov/pubmed/3005475 PubMed 3282546 http://www.ncbi.nlm.nih.gov/pubmed/3282546 PubMed 3541901 http://www.ncbi.nlm.nih.gov/pubmed/3541901 PubMed 6328431 http://www.ncbi.nlm.nih.gov/pubmed/6328431 PubMed 7592392 http://www.ncbi.nlm.nih.gov/pubmed/7592392 PubMed 8496960 http://www.ncbi.nlm.nih.gov/pubmed/8496960 PubMed 8909293 http://www.ncbi.nlm.nih.gov/pubmed/8909293 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9098893 http://www.ncbi.nlm.nih.gov/pubmed/9098893 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_416128 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416128 RefSeq WP_001099085 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001099085 SMR P05042 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P05042 STRING 511145.b1611 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1611&targetmode=cogs STRING COG0114 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0114&targetmode=cogs SUPFAM SSF48557 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48557 TIGRFAMs TIGR00979 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00979 UniProtKB FUMC_ECOLI http://www.uniprot.org/uniprot/FUMC_ECOLI UniProtKB-AC P05042 http://www.uniprot.org/uniprot/P05042 charge swissprot:FUMC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FUMC_ECOLI eggNOG COG0114 http://eggnogapi.embl.de/nog_data/html/tree/COG0114 eggNOG ENOG4105C9Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C9Q epestfind swissprot:FUMC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FUMC_ECOLI garnier swissprot:FUMC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FUMC_ECOLI helixturnhelix swissprot:FUMC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FUMC_ECOLI hmoment swissprot:FUMC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FUMC_ECOLI iep swissprot:FUMC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FUMC_ECOLI inforesidue swissprot:FUMC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FUMC_ECOLI octanol swissprot:FUMC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FUMC_ECOLI pepcoil swissprot:FUMC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FUMC_ECOLI pepdigest swissprot:FUMC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FUMC_ECOLI pepinfo swissprot:FUMC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FUMC_ECOLI pepnet swissprot:FUMC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FUMC_ECOLI pepstats swissprot:FUMC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FUMC_ECOLI pepwheel swissprot:FUMC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FUMC_ECOLI pepwindow swissprot:FUMC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FUMC_ECOLI sigcleave swissprot:FUMC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FUMC_ECOLI ## Database ID URL or Descriptions # BioGrid 4259834 29 # EcoGene EG10666 nusB # FUNCTION NUSB_ECOLI One of the proteins essential for the formation of the RNA polymerase antitermination complex in the presence of lambda phage N protein. However, it is involved in the transcription termination process at certain sites during normal bacterial growth. Binds to the BoxA RNA motif. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003723 RNA binding; IEA:UniProtKB-KW. # GO_process GO:0006353 DNA-templated transcription, termination; IEA:UniProtKB-HAMAP. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.940.10 -; 1. # HAMAP MF_00073 NusB # INTERACTION NUSB_ECOLI P0A7R5 rpsJ; NbExp=5; IntAct=EBI-555387, EBI-544602; # IntAct P0A780 12 # InterPro IPR006027 NusB_RsmB_TIM44 # InterPro IPR011605 NusB_fam # KEGG_Brite ko03009 Ribosome biogenesis # KEGG_Brite ko03021 Transcription machinery # Organism NUSB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11078 PTHR11078 # PATRIC 32115981 VBIEscCol129921_0432 # PDB 1EY1 NMR; -; A=1-139 # PDB 3D3B X-ray; 1.30 A; A=1-139 # PDB 3D3C X-ray; 2.60 A; A/B/C=1-139 # PDB 3IMQ X-ray; 2.50 A; A/B/C=3-139 # PIR I51822 FJECB # Pfam PF01029 NusB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NUSB_ECOLI N utilization substance protein B # RefSeq NP_414950 NC_000913.3 # RefSeq WP_000801125 NZ_LN832404.1 # SIMILARITY Belongs to the NusB family. {ECO 0000305}. # SUBUNIT NUSB_ECOLI Monomer. # SUPFAM SSF48013 SSF48013 # TIGRFAMs TIGR01951 nusB # eggNOG COG0781 LUCA # eggNOG ENOG4107YIM Bacteria BLAST swissprot:NUSB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NUSB_ECOLI BioCyc ECOL316407:JW0406-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0406-MONOMER BioCyc EcoCyc:EG10666-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10666-MONOMER COG COG0781 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0781 DIP DIP-48254N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48254N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1007/BF00538702 http://dx.doi.org/10.1007/BF00538702 DOI 10.1016/0065-227X(86)90022-5 http://dx.doi.org/10.1016/0065-227X(86)90022-5 DOI 10.1038/75869 http://dx.doi.org/10.1038/75869 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/emboj/17.14.4092 http://dx.doi.org/10.1093/emboj/17.14.4092 DOI 10.1093/nar/12.12.4977 http://dx.doi.org/10.1093/nar/12.12.4977 DOI 10.1093/nar/12.12.4987 http://dx.doi.org/10.1093/nar/12.12.4987 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M26839 http://www.ebi.ac.uk/ena/data/view/M26839 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL X00681 http://www.ebi.ac.uk/ena/data/view/X00681 EMBL X64395 http://www.ebi.ac.uk/ena/data/view/X64395 EchoBASE EB0660 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0660 EcoGene EG10666 http://www.ecogene.org/geneInfo.php?eg_id=EG10666 EnsemblBacteria AAC73519 http://www.ensemblgenomes.org/id/AAC73519 EnsemblBacteria AAC73519 http://www.ensemblgenomes.org/id/AAC73519 EnsemblBacteria BAE76196 http://www.ensemblgenomes.org/id/BAE76196 EnsemblBacteria BAE76196 http://www.ensemblgenomes.org/id/BAE76196 EnsemblBacteria BAE76196 http://www.ensemblgenomes.org/id/BAE76196 EnsemblBacteria b0416 http://www.ensemblgenomes.org/id/b0416 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_process GO:0006353 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006353 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.940.10 http://www.cathdb.info/version/latest/superfamily/1.10.940.10 GeneID 945054 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945054 HAMAP MF_00073 http://hamap.expasy.org/unirule/MF_00073 HOGENOM HOG000281868 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000281868&db=HOGENOM6 InParanoid P0A780 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A780 IntAct P0A780 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A780* InterPro IPR006027 http://www.ebi.ac.uk/interpro/entry/IPR006027 InterPro IPR011605 http://www.ebi.ac.uk/interpro/entry/IPR011605 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Brite ko03021 http://www.genome.jp/dbget-bin/www_bget?ko03021 KEGG_Gene ecj:JW0406 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0406 KEGG_Gene eco:b0416 http://www.genome.jp/dbget-bin/www_bget?eco:b0416 KEGG_Orthology KO:K03625 http://www.genome.jp/dbget-bin/www_bget?KO:K03625 MINT MINT-1220894 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1220894 OMA IPYKVVI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IPYKVVI PANTHER PTHR11078 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11078 PDB 1EY1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1EY1 PDB 3D3B http://www.ebi.ac.uk/pdbe-srv/view/entry/3D3B PDB 3D3C http://www.ebi.ac.uk/pdbe-srv/view/entry/3D3C PDB 3IMQ http://www.ebi.ac.uk/pdbe-srv/view/entry/3IMQ PDBsum 1EY1 http://www.ebi.ac.uk/pdbsum/1EY1 PDBsum 3D3B http://www.ebi.ac.uk/pdbsum/3D3B PDBsum 3D3C http://www.ebi.ac.uk/pdbsum/3D3C PDBsum 3IMQ http://www.ebi.ac.uk/pdbsum/3IMQ PSORT swissprot:NUSB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NUSB_ECOLI PSORT-B swissprot:NUSB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NUSB_ECOLI PSORT2 swissprot:NUSB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NUSB_ECOLI Pfam PF01029 http://pfam.xfam.org/family/PF01029 Phobius swissprot:NUSB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NUSB_ECOLI PhylomeDB P0A780 http://phylomedb.org/?seqid=P0A780 ProteinModelPortal P0A780 http://www.proteinmodelportal.org/query/uniprot/P0A780 PubMed 10881193 http://www.ncbi.nlm.nih.gov/pubmed/10881193 PubMed 1406588 http://www.ncbi.nlm.nih.gov/pubmed/1406588 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3019094 http://www.ncbi.nlm.nih.gov/pubmed/3019094 PubMed 6330693 http://www.ncbi.nlm.nih.gov/pubmed/6330693 PubMed 6330694 http://www.ncbi.nlm.nih.gov/pubmed/6330694 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9670024 http://www.ncbi.nlm.nih.gov/pubmed/9670024 RefSeq NP_414950 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414950 RefSeq WP_000801125 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000801125 SMR P0A780 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A780 STRING 511145.b0416 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0416&targetmode=cogs STRING COG0781 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0781&targetmode=cogs SUPFAM SSF48013 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48013 TIGRFAMs TIGR01951 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01951 UniProtKB NUSB_ECOLI http://www.uniprot.org/uniprot/NUSB_ECOLI UniProtKB-AC P0A780 http://www.uniprot.org/uniprot/P0A780 charge swissprot:NUSB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NUSB_ECOLI eggNOG COG0781 http://eggnogapi.embl.de/nog_data/html/tree/COG0781 eggNOG ENOG4107YIM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107YIM epestfind swissprot:NUSB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NUSB_ECOLI garnier swissprot:NUSB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NUSB_ECOLI helixturnhelix swissprot:NUSB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NUSB_ECOLI hmoment swissprot:NUSB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NUSB_ECOLI iep swissprot:NUSB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NUSB_ECOLI inforesidue swissprot:NUSB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NUSB_ECOLI octanol swissprot:NUSB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NUSB_ECOLI pepcoil swissprot:NUSB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NUSB_ECOLI pepdigest swissprot:NUSB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NUSB_ECOLI pepinfo swissprot:NUSB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NUSB_ECOLI pepnet swissprot:NUSB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NUSB_ECOLI pepstats swissprot:NUSB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NUSB_ECOLI pepwheel swissprot:NUSB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NUSB_ECOLI pepwindow swissprot:NUSB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NUSB_ECOLI sigcleave swissprot:NUSB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NUSB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260915 5 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG13641 ybcY # Gene3D 3.40.50.150 -; 1. # IntAct P77460 8 # InterPro IPR013217 Methyltransf_12 # InterPro IPR016584 MeTrfase_VrtF # InterPro IPR029063 SAM-dependent_MTases # MISCELLANEOUS YBCY_ECOLI Encoded by the cryptic lambdoid prophage DLP12. # Organism YBCY_ECOLI Escherichia coli (strain K12) # PIR H64788 H64788 # PIRSF PIRSF011491 Mtase_YbcY_prd # Pfam PF08242 Methyltransf_12 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBCY_ECOLI Putative uncharacterized protein YbcY # RefSeq WP_000365231 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40758.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SUPFAM SSF53335 SSF53335 # eggNOG COG0500 LUCA # eggNOG ENOG4108WF3 Bacteria BLAST swissprot:YBCY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBCY_ECOLI BioCyc ECOL316407:JW0551-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0551-MONOMER BioCyc EcoCyc:G6316-MONOMER http://biocyc.org/getid?id=EcoCyc:G6316-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB3405 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3405 EcoGene EG13641 http://www.ecogene.org/geneInfo.php?eg_id=EG13641 EnsemblBacteria BAE76337 http://www.ensemblgenomes.org/id/BAE76337 EnsemblBacteria BAE76337 http://www.ensemblgenomes.org/id/BAE76337 EnsemblBacteria BAE76337 http://www.ensemblgenomes.org/id/BAE76337 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 InParanoid P77460 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77460 IntAct P77460 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77460* InterPro IPR013217 http://www.ebi.ac.uk/interpro/entry/IPR013217 InterPro IPR016584 http://www.ebi.ac.uk/interpro/entry/IPR016584 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 KEGG_Gene ecj:JW0551 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0551 OMA NYLLHCL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NYLLHCL PSORT swissprot:YBCY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBCY_ECOLI PSORT-B swissprot:YBCY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBCY_ECOLI PSORT2 swissprot:YBCY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBCY_ECOLI Pfam PF08242 http://pfam.xfam.org/family/PF08242 Phobius swissprot:YBCY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBCY_ECOLI PhylomeDB P77460 http://phylomedb.org/?seqid=P77460 ProteinModelPortal P77460 http://www.proteinmodelportal.org/query/uniprot/P77460 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000365231 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000365231 SMR P77460 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77460 STRING 316407.85674697 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85674697&targetmode=cogs SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 UniProtKB YBCY_ECOLI http://www.uniprot.org/uniprot/YBCY_ECOLI UniProtKB-AC P77460 http://www.uniprot.org/uniprot/P77460 charge swissprot:YBCY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBCY_ECOLI eggNOG COG0500 http://eggnogapi.embl.de/nog_data/html/tree/COG0500 eggNOG ENOG4108WF3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108WF3 epestfind swissprot:YBCY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBCY_ECOLI garnier swissprot:YBCY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBCY_ECOLI helixturnhelix swissprot:YBCY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBCY_ECOLI hmoment swissprot:YBCY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBCY_ECOLI iep swissprot:YBCY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBCY_ECOLI inforesidue swissprot:YBCY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBCY_ECOLI octanol swissprot:YBCY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBCY_ECOLI pepcoil swissprot:YBCY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBCY_ECOLI pepdigest swissprot:YBCY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBCY_ECOLI pepinfo swissprot:YBCY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBCY_ECOLI pepnet swissprot:YBCY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBCY_ECOLI pepstats swissprot:YBCY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBCY_ECOLI pepwheel swissprot:YBCY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBCY_ECOLI pepwindow swissprot:YBCY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBCY_ECOLI sigcleave swissprot:YBCY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBCY_ECOLI ## Database ID URL or Descriptions # BioGrid 4261255 228 # EcoGene EG11650 yafD # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GOslim_component GO:0005737 cytoplasm # Gene3D 3.60.10.10 -; 1. # HAMAP MF_01119 UPF0294 # InterPro IPR005135 Endo/exonuclease/phosphatase # InterPro IPR022958 UPF0294 # Organism YAFD_ECOLI Escherichia coli (strain K12) # PATRIC 32115531 VBIEscCol129921_0211 # PIR C64745 C64745 # Pfam PF03372 Exo_endo_phos # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAFD_ECOLI UPF0294 protein YafD # RefSeq NP_414745 NC_000913.3 # RefSeq WP_001230983 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB08631.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA02172.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the UPF0294 family. {ECO 0000305}. # SUBCELLULAR LOCATION YAFD_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF56219 SSF56219 # eggNOG COG3021 LUCA # eggNOG ENOG4107NA1 Bacteria BLAST swissprot:YAFD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAFD_ECOLI BioCyc ECOL316407:JW5017-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5017-MONOMER BioCyc EcoCyc:EG11650-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11650-MONOMER DIP DIP-47877N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47877N DOI 10.1016/0378-1097(91)90355-E http://dx.doi.org/10.1016/0378-1097(91)90355-E DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D12650 http://www.ebi.ac.uk/ena/data/view/D12650 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EMBL X60739 http://www.ebi.ac.uk/ena/data/view/X60739 EchoBASE EB1603 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1603 EcoGene EG11650 http://www.ecogene.org/geneInfo.php?eg_id=EG11650 EnsemblBacteria AAC73314 http://www.ensemblgenomes.org/id/AAC73314 EnsemblBacteria AAC73314 http://www.ensemblgenomes.org/id/AAC73314 EnsemblBacteria BAA77880 http://www.ensemblgenomes.org/id/BAA77880 EnsemblBacteria BAA77880 http://www.ensemblgenomes.org/id/BAA77880 EnsemblBacteria BAA77880 http://www.ensemblgenomes.org/id/BAA77880 EnsemblBacteria b0209 http://www.ensemblgenomes.org/id/b0209 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 Gene3D 3.60.10.10 http://www.cathdb.info/version/latest/superfamily/3.60.10.10 GeneID 946286 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946286 HAMAP MF_01119 http://hamap.expasy.org/unirule/MF_01119 HOGENOM HOG000275410 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275410&db=HOGENOM6 InParanoid P0A8U2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8U2 InterPro IPR005135 http://www.ebi.ac.uk/interpro/entry/IPR005135 InterPro IPR022958 http://www.ebi.ac.uk/interpro/entry/IPR022958 KEGG_Gene ecj:JW5017 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5017 KEGG_Gene eco:b0209 http://www.genome.jp/dbget-bin/www_bget?eco:b0209 OMA CCPLREK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CCPLREK PSORT swissprot:YAFD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAFD_ECOLI PSORT-B swissprot:YAFD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAFD_ECOLI PSORT2 swissprot:YAFD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAFD_ECOLI Pfam PF03372 http://pfam.xfam.org/family/PF03372 Phobius swissprot:YAFD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAFD_ECOLI PhylomeDB P0A8U2 http://phylomedb.org/?seqid=P0A8U2 ProteinModelPortal P0A8U2 http://www.proteinmodelportal.org/query/uniprot/P0A8U2 PubMed 1663890 http://www.ncbi.nlm.nih.gov/pubmed/1663890 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414745 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414745 RefSeq WP_001230983 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001230983 STRING 511145.b0209 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0209&targetmode=cogs SUPFAM SSF56219 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56219 UniProtKB YAFD_ECOLI http://www.uniprot.org/uniprot/YAFD_ECOLI UniProtKB-AC P0A8U2 http://www.uniprot.org/uniprot/P0A8U2 charge swissprot:YAFD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAFD_ECOLI eggNOG COG3021 http://eggnogapi.embl.de/nog_data/html/tree/COG3021 eggNOG ENOG4107NA1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107NA1 epestfind swissprot:YAFD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAFD_ECOLI garnier swissprot:YAFD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAFD_ECOLI helixturnhelix swissprot:YAFD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAFD_ECOLI hmoment swissprot:YAFD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAFD_ECOLI iep swissprot:YAFD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAFD_ECOLI inforesidue swissprot:YAFD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAFD_ECOLI octanol swissprot:YAFD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAFD_ECOLI pepcoil swissprot:YAFD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAFD_ECOLI pepdigest swissprot:YAFD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAFD_ECOLI pepinfo swissprot:YAFD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAFD_ECOLI pepnet swissprot:YAFD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAFD_ECOLI pepstats swissprot:YAFD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAFD_ECOLI pepwheel swissprot:YAFD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAFD_ECOLI pepwindow swissprot:YAFD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAFD_ECOLI sigcleave swissprot:YAFD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAFD_ECOLI ## Database ID URL or Descriptions # AltName PERR_ECOLI Peroxide resistance protein PerR # BioGrid 4259774 3 # EcoGene EG13340 perR # FUNCTION PERR_ECOLI Apparent regulatory gene involved in peroxide resistance in stationary phase. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0043565 sequence-specific DNA binding; IBA:GO_Central. # GO_process GO:0006351 transcription, DNA-templated; IBA:GO_Central. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # INTERACTION PERR_ECOLI Self; NbExp=3; IntAct=EBI-541993, EBI-541993; # IntAct Q57083 6 # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR005119 LysR_subst-bd # InterPro IPR011991 WHTH_DNA-bd_dom # Organism PERR_ECOLI Escherichia coli (strain K12) # PATRIC 32115627 VBIEscCol129921_0257 # PIR F64750 F64750 # PRINTS PR00039 HTHLYSR # PROSITE PS50931 HTH_LYSR # Pfam PF00126 HTH_1 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PERR_ECOLI HTH-type transcriptional regulator PerR # RefSeq NP_414788 NC_000913.3 # RefSeq WP_000770246 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lysR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00253}. # SUPFAM SSF46785 SSF46785 # eggNOG ENOG4108PZW Bacteria # eggNOG ENOG410Z3XZ LUCA BLAST swissprot:PERR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PERR_ECOLI BioCyc ECOL316407:JW0244-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0244-MONOMER BioCyc EcoCyc:G6129-MONOMER http://biocyc.org/getid?id=EcoCyc:G6129-MONOMER DIP DIP-10463N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10463N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U57080 http://www.ebi.ac.uk/ena/data/view/U57080 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EchoBASE EB3124 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3124 EcoGene EG13340 http://www.ecogene.org/geneInfo.php?eg_id=EG13340 EnsemblBacteria AAC73357 http://www.ensemblgenomes.org/id/AAC73357 EnsemblBacteria AAC73357 http://www.ensemblgenomes.org/id/AAC73357 EnsemblBacteria BAA77924 http://www.ensemblgenomes.org/id/BAA77924 EnsemblBacteria BAA77924 http://www.ensemblgenomes.org/id/BAA77924 EnsemblBacteria BAA77924 http://www.ensemblgenomes.org/id/BAA77924 EnsemblBacteria b0254 http://www.ensemblgenomes.org/id/b0254 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 945417 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945417 HOGENOM HOG000233528 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000233528&db=HOGENOM6 InParanoid Q57083 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q57083 IntAct Q57083 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q57083* InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW0244 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0244 KEGG_Gene eco:b0254 http://www.genome.jp/dbget-bin/www_bget?eco:b0254 MINT MINT-1292741 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1292741 OMA AYCSPAY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AYCSPAY PRINTS PR00039 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00039 PROSITE PS50931 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50931 PSORT swissprot:PERR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PERR_ECOLI PSORT-B swissprot:PERR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PERR_ECOLI PSORT2 swissprot:PERR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PERR_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:PERR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PERR_ECOLI PhylomeDB Q57083 http://phylomedb.org/?seqid=Q57083 ProteinModelPortal Q57083 http://www.proteinmodelportal.org/query/uniprot/Q57083 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414788 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414788 RefSeq WP_000770246 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000770246 SMR Q57083 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q57083 STRING 511145.b0254 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0254&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB PERR_ECOLI http://www.uniprot.org/uniprot/PERR_ECOLI UniProtKB-AC Q57083 http://www.uniprot.org/uniprot/Q57083 charge swissprot:PERR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PERR_ECOLI eggNOG ENOG4108PZW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108PZW eggNOG ENOG410Z3XZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Z3XZ epestfind swissprot:PERR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PERR_ECOLI garnier swissprot:PERR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PERR_ECOLI helixturnhelix swissprot:PERR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PERR_ECOLI hmoment swissprot:PERR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PERR_ECOLI iep swissprot:PERR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PERR_ECOLI inforesidue swissprot:PERR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PERR_ECOLI octanol swissprot:PERR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PERR_ECOLI pepcoil swissprot:PERR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PERR_ECOLI pepdigest swissprot:PERR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PERR_ECOLI pepinfo swissprot:PERR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PERR_ECOLI pepnet swissprot:PERR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PERR_ECOLI pepstats swissprot:PERR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PERR_ECOLI pepwheel swissprot:PERR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PERR_ECOLI pepwindow swissprot:PERR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PERR_ECOLI sigcleave swissprot:PERR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PERR_ECOLI ## Database ID URL or Descriptions # BioGrid 4259965 9 # EcoGene EG11580 ybiB # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0003723 RNA binding; IDA:EcoCyc. # GO_function GO:0016757 transferase activity, transferring glycosyl groups; IEA:UniProtKB-KW. # GO_process GO:0008152 metabolic process; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_process GO:0008150 biological_process # Gene3D 3.40.1030.10 -; 1. # IntAct P30177 10 # InterPro IPR000312 Glycosyl_Trfase_fam3 # InterPro IPR017459 Glycosyl_Trfase_fam3_N_dom # Organism YBIB_ECOLI Escherichia coli (strain K12) # PATRIC 32116803 VBIEscCol129921_0827 # PDB 4MUO X-ray; 1.94 A; A/B=1-320 # PIR H64816 H64816 # Pfam PF02885 Glycos_trans_3N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBIB_ECOLI Uncharacterized protein YbiB # RefSeq NP_415321 NC_000913.3 # RefSeq WP_000386551 NZ_LN832404.1 # SIMILARITY Belongs to the anthranilate phosphoribosyltransferase family. {ECO 0000305}. # SUPFAM SSF47648 SSF47648 # SUPFAM SSF52418 SSF52418 # eggNOG COG0547 LUCA # eggNOG ENOG4108MTB Bacteria BLAST swissprot:YBIB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBIB_ECOLI BioCyc ECOL316407:JW0785-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0785-MONOMER BioCyc EcoCyc:EG11580-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11580-MONOMER DIP DIP-11425N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11425N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1266/ggs.82.291 http://dx.doi.org/10.1266/ggs.82.291 DOI 10.1266/jjg.69.1 http://dx.doi.org/10.1266/jjg.69.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L02123 http://www.ebi.ac.uk/ena/data/view/L02123 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1540 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1540 EcoGene EG11580 http://www.ecogene.org/geneInfo.php?eg_id=EG11580 EnsemblBacteria AAC73887 http://www.ensemblgenomes.org/id/AAC73887 EnsemblBacteria AAC73887 http://www.ensemblgenomes.org/id/AAC73887 EnsemblBacteria BAA35466 http://www.ensemblgenomes.org/id/BAA35466 EnsemblBacteria BAA35466 http://www.ensemblgenomes.org/id/BAA35466 EnsemblBacteria BAA35466 http://www.ensemblgenomes.org/id/BAA35466 EnsemblBacteria b0800 http://www.ensemblgenomes.org/id/b0800 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GO_process GO:0008152 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008152 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.1030.10 http://www.cathdb.info/version/latest/superfamily/3.40.1030.10 GeneID 945424 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945424 HOGENOM HOG000264819 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000264819&db=HOGENOM6 InParanoid P30177 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30177 IntAct P30177 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P30177* InterPro IPR000312 http://www.ebi.ac.uk/interpro/entry/IPR000312 InterPro IPR017459 http://www.ebi.ac.uk/interpro/entry/IPR017459 KEGG_Gene ecj:JW0785 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0785 KEGG_Gene eco:b0800 http://www.genome.jp/dbget-bin/www_bget?eco:b0800 OMA EVTARWI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EVTARWI PDB 4MUO http://www.ebi.ac.uk/pdbe-srv/view/entry/4MUO PDBsum 4MUO http://www.ebi.ac.uk/pdbsum/4MUO PSORT swissprot:YBIB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBIB_ECOLI PSORT-B swissprot:YBIB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBIB_ECOLI PSORT2 swissprot:YBIB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBIB_ECOLI Pfam PF02885 http://pfam.xfam.org/family/PF02885 Phobius swissprot:YBIB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBIB_ECOLI PhylomeDB P30177 http://phylomedb.org/?seqid=P30177 ProteinModelPortal P30177 http://www.proteinmodelportal.org/query/uniprot/P30177 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17895580 http://www.ncbi.nlm.nih.gov/pubmed/17895580 PubMed 8037924 http://www.ncbi.nlm.nih.gov/pubmed/8037924 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415321 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415321 RefSeq WP_000386551 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000386551 SMR P30177 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P30177 STRING 511145.b0800 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0800&targetmode=cogs SUPFAM SSF47648 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47648 SUPFAM SSF52418 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52418 UniProtKB YBIB_ECOLI http://www.uniprot.org/uniprot/YBIB_ECOLI UniProtKB-AC P30177 http://www.uniprot.org/uniprot/P30177 charge swissprot:YBIB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBIB_ECOLI eggNOG COG0547 http://eggnogapi.embl.de/nog_data/html/tree/COG0547 eggNOG ENOG4108MTB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MTB epestfind swissprot:YBIB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBIB_ECOLI garnier swissprot:YBIB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBIB_ECOLI helixturnhelix swissprot:YBIB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBIB_ECOLI hmoment swissprot:YBIB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBIB_ECOLI iep swissprot:YBIB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBIB_ECOLI inforesidue swissprot:YBIB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBIB_ECOLI octanol swissprot:YBIB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBIB_ECOLI pepcoil swissprot:YBIB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBIB_ECOLI pepdigest swissprot:YBIB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBIB_ECOLI pepinfo swissprot:YBIB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBIB_ECOLI pepnet swissprot:YBIB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBIB_ECOLI pepstats swissprot:YBIB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBIB_ECOLI pepwheel swissprot:YBIB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBIB_ECOLI pepwindow swissprot:YBIB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBIB_ECOLI sigcleave swissprot:YBIB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBIB_ECOLI ## Database ID URL or Descriptions # BRENDA 2.3.3.16 2026 # BioGrid 4259941 9 # CATALYTIC ACTIVITY Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA. {ECO:0000255|PROSITE-ProRule PRU10117}. # ENZYME REGULATION CISY_ECOLI Allosterically inhibited by NADH. # EcoGene EG10402 gltA # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0004108 citrate (Si)-synthase activity; IEA:InterPro. # GO_function GO:0042802 identical protein binding; IPI:IntAct. # GO_process GO:0006099 tricarboxylic acid cycle; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.230.10 -; 1. # Gene3D 1.10.580.10 -; 1. # INTERACTION CISY_ECOLI Self; NbExp=5; IntAct=EBI-547808, EBI-547808; P76407 yegS; NbExp=2; IntAct=EBI-547808, EBI-1127478; # IntAct P0ABH7 9 # InterPro IPR002020 Citrate_synthase # InterPro IPR010953 Citrate_synthase_typ-I # InterPro IPR016142 Citrate_synth-like_lrg_a-sub # InterPro IPR016143 Citrate_synth-like_sm_a-sub # InterPro IPR019810 Citrate_synthase_AS # InterPro IPR024176 Citrate_synthase_bac-typ # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00020 Citrate cycle (TCA cycle) # KEGG_Pathway ko00630 Glyoxylate and dicarboxylate metabolism # MISCELLANEOUS CISY_ECOLI Citrate synthase is found in nearly all cells capable of oxidative metabolism. # Organism CISY_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11739 PTHR11739 # PATHWAY Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate step 1/2. # PATRIC 32116635 VBIEscCol129921_0750 # PDB 1NXE X-ray; 2.30 A; A/B=1-427 # PDB 1NXG X-ray; 2.50 A; A/B=1-427 # PDB 1OWB X-ray; 2.20 A; A/B=1-427 # PDB 1OWC X-ray; 2.20 A; A/B=1-427 # PDB 4G6B X-ray; 2.20 A; A/B=2-427 # PDB 4JAD X-ray; 1.90 A; A/B=2-427 # PDB 4JAE X-ray; 2.70 A; A/B=2-427 # PDB 4JAF X-ray; 2.30 A; A/B=2-427 # PDB 4JAG X-ray; 2.10 A; A/B=2-427 # PIR G64807 YKEC # PIRSF PIRSF001369 Citrate_synth # PRINTS PR00143 CITRTSNTHASE # PROSITE PS00480 CITRATE_SYNTHASE # Pfam PF00285 Citrate_synt # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CISY_ECOLI Citrate synthase # RefSeq NP_415248 NC_000913.3 # RefSeq WP_000785834 NZ_LN832404.1 # SIMILARITY Belongs to the citrate synthase family. {ECO 0000305}. # SUBUNIT CISY_ECOLI Homohexamer. # SUPFAM SSF48256 SSF48256 # TIGRFAMs TIGR01798 cit_synth_I # UniPathway UPA00223 UER00717 # eggNOG COG0372 LUCA # eggNOG ENOG4105BZN Bacteria BLAST swissprot:CISY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CISY_ECOLI BioCyc ECOL316407:JW0710-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0710-MONOMER BioCyc EcoCyc:CITSYN-MONOMER http://biocyc.org/getid?id=EcoCyc:CITSYN-MONOMER BioCyc MetaCyc:CITSYN-MONOMER http://biocyc.org/getid?id=MetaCyc:CITSYN-MONOMER COG COG0372 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0372 DIP DIP-36204N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36204N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0014-5793(83)80530-4 http://dx.doi.org/10.1016/0014-5793(83)80530-4 DOI 10.1016/0020-711X(86)90115-1 http://dx.doi.org/10.1016/0020-711X(86)90115-1 DOI 10.1021/bi00308a008 http://dx.doi.org/10.1021/bi00308a008 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2220519 http://dx.doi.org/10.1042/bj2220519 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1099/00221287-132-12-3239 http://dx.doi.org/10.1099/00221287-132-12-3239 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.3.16 http://www.genome.jp/dbget-bin/www_bget?EC:2.3.3.16 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01619 http://www.ebi.ac.uk/ena/data/view/J01619 EMBL M28987 http://www.ebi.ac.uk/ena/data/view/M28987 EMBL M29373 http://www.ebi.ac.uk/ena/data/view/M29373 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V01501 http://www.ebi.ac.uk/ena/data/view/V01501 EMBL X00980 http://www.ebi.ac.uk/ena/data/view/X00980 ENZYME 2.3.3.16 http://enzyme.expasy.org/EC/2.3.3.16 EchoBASE EB0397 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0397 EcoGene EG10402 http://www.ecogene.org/geneInfo.php?eg_id=EG10402 EnsemblBacteria AAC73814 http://www.ensemblgenomes.org/id/AAC73814 EnsemblBacteria AAC73814 http://www.ensemblgenomes.org/id/AAC73814 EnsemblBacteria BAA35384 http://www.ensemblgenomes.org/id/BAA35384 EnsemblBacteria BAA35384 http://www.ensemblgenomes.org/id/BAA35384 EnsemblBacteria BAA35384 http://www.ensemblgenomes.org/id/BAA35384 EnsemblBacteria b0720 http://www.ensemblgenomes.org/id/b0720 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004108 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004108 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0006099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006099 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.230.10 http://www.cathdb.info/version/latest/superfamily/1.10.230.10 Gene3D 1.10.580.10 http://www.cathdb.info/version/latest/superfamily/1.10.580.10 GeneID 945323 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945323 HOGENOM HOG000021224 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000021224&db=HOGENOM6 InParanoid P0ABH7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABH7 IntAct P0ABH7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABH7* IntEnz 2.3.3.16 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.3.16 InterPro IPR002020 http://www.ebi.ac.uk/interpro/entry/IPR002020 InterPro IPR010953 http://www.ebi.ac.uk/interpro/entry/IPR010953 InterPro IPR016142 http://www.ebi.ac.uk/interpro/entry/IPR016142 InterPro IPR016143 http://www.ebi.ac.uk/interpro/entry/IPR016143 InterPro IPR019810 http://www.ebi.ac.uk/interpro/entry/IPR019810 InterPro IPR024176 http://www.ebi.ac.uk/interpro/entry/IPR024176 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0710 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0710 KEGG_Gene eco:b0720 http://www.genome.jp/dbget-bin/www_bget?eco:b0720 KEGG_Orthology KO:K01647 http://www.genome.jp/dbget-bin/www_bget?KO:K01647 KEGG_Pathway ko00020 http://www.genome.jp/kegg-bin/show_pathway?ko00020 KEGG_Pathway ko00630 http://www.genome.jp/kegg-bin/show_pathway?ko00630 KEGG_Reaction rn:R00351 http://www.genome.jp/dbget-bin/www_bget?rn:R00351 MINT MINT-1249502 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1249502 OMA NKEDGVR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NKEDGVR PANTHER PTHR11739 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11739 PDB 1NXE http://www.ebi.ac.uk/pdbe-srv/view/entry/1NXE PDB 1NXG http://www.ebi.ac.uk/pdbe-srv/view/entry/1NXG PDB 1OWB http://www.ebi.ac.uk/pdbe-srv/view/entry/1OWB PDB 1OWC http://www.ebi.ac.uk/pdbe-srv/view/entry/1OWC PDB 4G6B http://www.ebi.ac.uk/pdbe-srv/view/entry/4G6B PDB 4JAD http://www.ebi.ac.uk/pdbe-srv/view/entry/4JAD PDB 4JAE http://www.ebi.ac.uk/pdbe-srv/view/entry/4JAE PDB 4JAF http://www.ebi.ac.uk/pdbe-srv/view/entry/4JAF PDB 4JAG http://www.ebi.ac.uk/pdbe-srv/view/entry/4JAG PDBsum 1NXE http://www.ebi.ac.uk/pdbsum/1NXE PDBsum 1NXG http://www.ebi.ac.uk/pdbsum/1NXG PDBsum 1OWB http://www.ebi.ac.uk/pdbsum/1OWB PDBsum 1OWC http://www.ebi.ac.uk/pdbsum/1OWC PDBsum 4G6B http://www.ebi.ac.uk/pdbsum/4G6B PDBsum 4JAD http://www.ebi.ac.uk/pdbsum/4JAD PDBsum 4JAE http://www.ebi.ac.uk/pdbsum/4JAE PDBsum 4JAF http://www.ebi.ac.uk/pdbsum/4JAF PDBsum 4JAG http://www.ebi.ac.uk/pdbsum/4JAG PRINTS PR00143 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00143 PROSITE PS00480 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00480 PSORT swissprot:CISY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CISY_ECOLI PSORT-B swissprot:CISY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CISY_ECOLI PSORT2 swissprot:CISY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CISY_ECOLI Pfam PF00285 http://pfam.xfam.org/family/PF00285 Phobius swissprot:CISY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CISY_ECOLI PhylomeDB P0ABH7 http://phylomedb.org/?seqid=P0ABH7 ProteinModelPortal P0ABH7 http://www.proteinmodelportal.org/query/uniprot/P0ABH7 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 1939121 http://www.ncbi.nlm.nih.gov/pubmed/1939121 PubMed 3309132 http://www.ncbi.nlm.nih.gov/pubmed/3309132 PubMed 3514304 http://www.ncbi.nlm.nih.gov/pubmed/3514304 PubMed 6343122 http://www.ncbi.nlm.nih.gov/pubmed/6343122 PubMed 6380576 http://www.ncbi.nlm.nih.gov/pubmed/6380576 PubMed 6383359 http://www.ncbi.nlm.nih.gov/pubmed/6383359 PubMed 7730298 http://www.ncbi.nlm.nih.gov/pubmed/7730298 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_415248 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415248 RefSeq WP_000785834 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000785834 SMR P0ABH7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABH7 STRING 511145.b0720 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0720&targetmode=cogs STRING COG0372 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0372&targetmode=cogs SUPFAM SSF48256 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48256 TIGRFAMs TIGR01798 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01798 UniProtKB CISY_ECOLI http://www.uniprot.org/uniprot/CISY_ECOLI UniProtKB-AC P0ABH7 http://www.uniprot.org/uniprot/P0ABH7 charge swissprot:CISY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CISY_ECOLI eggNOG COG0372 http://eggnogapi.embl.de/nog_data/html/tree/COG0372 eggNOG ENOG4105BZN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZN epestfind swissprot:CISY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CISY_ECOLI garnier swissprot:CISY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CISY_ECOLI helixturnhelix swissprot:CISY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CISY_ECOLI hmoment swissprot:CISY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CISY_ECOLI iep swissprot:CISY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CISY_ECOLI inforesidue swissprot:CISY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CISY_ECOLI octanol swissprot:CISY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CISY_ECOLI pepcoil swissprot:CISY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CISY_ECOLI pepdigest swissprot:CISY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CISY_ECOLI pepinfo swissprot:CISY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CISY_ECOLI pepnet swissprot:CISY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CISY_ECOLI pepstats swissprot:CISY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CISY_ECOLI pepwheel swissprot:CISY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CISY_ECOLI pepwindow swissprot:CISY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CISY_ECOLI sigcleave swissprot:CISY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CISY_ECOLI ## Database ID URL or Descriptions # BioGrid 4260906 7 # CDD cd07377 WHTH_GntR # EcoGene EG11962 lldR # FUNCTION LLDR_ECOLI May be a regulatory protein for the LCT genes. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_function GO:0043565 sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0044010 single-species biofilm formation; IMP:EcoCyc. # GO_process GO:0045990 carbon catabolite regulation of transcription; IMP:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # Gene3D 1.20.120.530 -; 1. # INDUCTION LLDR_ECOLI By L-lactate; aerobically. # IntAct P0ACL7 5 # InterPro IPR000524 Tscrpt_reg_HTH_GntR # InterPro IPR008920 TF_FadR/GntR_C # InterPro IPR011711 GntR_C # InterPro IPR011991 WHTH_DNA-bd_dom # KEGG_Brite ko03000 Transcription factors # Organism LLDR_ECOLI Escherichia coli (strain K12) # PATRIC 32122693 VBIEscCol129921_3723 # PIR B49904 B49904 # PRINTS PR00035 HTHGNTR # PROSITE PS50949 HTH_GNTR # Pfam PF00392 GntR # Pfam PF07729 FCD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LLDR_ECOLI Putative L-lactate dehydrogenase operon regulatory protein # RefSeq NP_418061 NC_000913.3 # RefSeq WP_000636500 NZ_LN832404.1 # SIMILARITY Contains 1 HTH gntR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00307}. # SMART SM00345 HTH_GNTR # SMART SM00895 FCD # SUPFAM SSF46785 SSF46785 # SUPFAM SSF48008 SSF48008 # eggNOG COG2186 LUCA # eggNOG ENOG41073TP Bacteria BLAST swissprot:LLDR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LLDR_ECOLI BioCyc ECOL316407:JW3579-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3579-MONOMER BioCyc EcoCyc:EG11962-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11962-MONOMER COG COG2186 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2186 DIP DIP-10110N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10110N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L13970 http://www.ebi.ac.uk/ena/data/view/L13970 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1905 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1905 EcoGene EG11962 http://www.ecogene.org/geneInfo.php?eg_id=EG11962 EnsemblBacteria AAC76628 http://www.ensemblgenomes.org/id/AAC76628 EnsemblBacteria AAC76628 http://www.ensemblgenomes.org/id/AAC76628 EnsemblBacteria BAE77688 http://www.ensemblgenomes.org/id/BAE77688 EnsemblBacteria BAE77688 http://www.ensemblgenomes.org/id/BAE77688 EnsemblBacteria BAE77688 http://www.ensemblgenomes.org/id/BAE77688 EnsemblBacteria b3604 http://www.ensemblgenomes.org/id/b3604 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0044010 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044010 GO_process GO:0045990 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045990 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 1.20.120.530 http://www.cathdb.info/version/latest/superfamily/1.20.120.530 GeneID 948122 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948122 HOGENOM HOG000273991 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000273991&db=HOGENOM6 InParanoid P0ACL7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACL7 IntAct P0ACL7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACL7* InterPro IPR000524 http://www.ebi.ac.uk/interpro/entry/IPR000524 InterPro IPR008920 http://www.ebi.ac.uk/interpro/entry/IPR008920 InterPro IPR011711 http://www.ebi.ac.uk/interpro/entry/IPR011711 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW3579 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3579 KEGG_Gene eco:b3604 http://www.genome.jp/dbget-bin/www_bget?eco:b3604 KEGG_Orthology KO:K14348 http://www.genome.jp/dbget-bin/www_bget?KO:K14348 OMA DVTFHSM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DVTFHSM PRINTS PR00035 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00035 PROSITE PS50949 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50949 PSORT swissprot:LLDR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LLDR_ECOLI PSORT-B swissprot:LLDR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LLDR_ECOLI PSORT2 swissprot:LLDR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LLDR_ECOLI Pfam PF00392 http://pfam.xfam.org/family/PF00392 Pfam PF07729 http://pfam.xfam.org/family/PF07729 Phobius swissprot:LLDR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LLDR_ECOLI PhylomeDB P0ACL7 http://phylomedb.org/?seqid=P0ACL7 ProteinModelPortal P0ACL7 http://www.proteinmodelportal.org/query/uniprot/P0ACL7 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 8407843 http://www.ncbi.nlm.nih.gov/pubmed/8407843 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418061 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418061 RefSeq WP_000636500 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000636500 SMART SM00345 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00345 SMART SM00895 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00895 SMR P0ACL7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACL7 STRING 511145.b3604 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3604&targetmode=cogs STRING COG2186 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2186&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SUPFAM SSF48008 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48008 UniProtKB LLDR_ECOLI http://www.uniprot.org/uniprot/LLDR_ECOLI UniProtKB-AC P0ACL7 http://www.uniprot.org/uniprot/P0ACL7 charge swissprot:LLDR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LLDR_ECOLI eggNOG COG2186 http://eggnogapi.embl.de/nog_data/html/tree/COG2186 eggNOG ENOG41073TP http://eggnogapi.embl.de/nog_data/html/tree/ENOG41073TP epestfind swissprot:LLDR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LLDR_ECOLI garnier swissprot:LLDR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LLDR_ECOLI helixturnhelix swissprot:LLDR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LLDR_ECOLI hmoment swissprot:LLDR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LLDR_ECOLI iep swissprot:LLDR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LLDR_ECOLI inforesidue swissprot:LLDR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LLDR_ECOLI octanol swissprot:LLDR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LLDR_ECOLI pepcoil swissprot:LLDR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LLDR_ECOLI pepdigest swissprot:LLDR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LLDR_ECOLI pepinfo swissprot:LLDR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LLDR_ECOLI pepnet swissprot:LLDR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LLDR_ECOLI pepstats swissprot:LLDR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LLDR_ECOLI pepwheel swissprot:LLDR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LLDR_ECOLI pepwindow swissprot:LLDR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LLDR_ECOLI sigcleave swissprot:LLDR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LLDR_ECOLI ## Database ID URL or Descriptions # BioGrid 4262968 210 # EcoGene EG14103 yfbS # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IBA:GO_Central. # GO_function GO:0005215 transporter activity; IBA:GO_Central. # GO_function GO:0008324 cation transmembrane transporter activity; IEA:InterPro. # GO_process GO:0006813 potassium ion transport; IEA:InterPro. # GO_process GO:0098656 anion transmembrane transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # Gene3D 3.30.70.1450 -; 2. # InterPro IPR004680 Cit_transptr-like_dom # InterPro IPR006037 RCK_C # InterPro IPR031312 Na/sul_symport_CS # Organism YFBS_ECOLI Escherichia coli (strain K12) # PATRIC 32119953 VBIEscCol129921_2386 # PIR B65001 B65001 # PROSITE PS01271 NA_SULFATE # PROSITE PS51202 RCK_C; 2 # Pfam PF02080 TrkA_C; 2 # Pfam PF03600 CitMHS; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFBS_ECOLI Uncharacterized transporter YfbS # RefSeq NP_416795 NC_000913.3 # RefSeq WP_001012899 NZ_LN832404.1 # SIMILARITY Belongs to the CitM (TC 2.A.11) transporter family. {ECO 0000305}. # SIMILARITY Contains 2 RCK C-terminal domains. {ECO:0000255|PROSITE-ProRule PRU00544}. # SUBCELLULAR LOCATION YFBS_ECOLI Cell inner membrane {ECO 0000305}; Multi- pass membrane protein {ECO 0000305}. # SUPFAM SSF116726 SSF116726; 2 # TCDB 2.A.47.4:the divalent anion na(+) symporter (dass) family # eggNOG COG0471 LUCA # eggNOG ENOG4107QWE Bacteria BLAST swissprot:YFBS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFBS_ECOLI BioCyc ECOL316407:JW2289-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2289-MONOMER BioCyc EcoCyc:G7186-MONOMER http://biocyc.org/getid?id=EcoCyc:G7186-MONOMER DIP DIP-48033N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48033N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3856 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3856 EcoGene EG14103 http://www.ecogene.org/geneInfo.php?eg_id=EG14103 EnsemblBacteria AAC75352 http://www.ensemblgenomes.org/id/AAC75352 EnsemblBacteria AAC75352 http://www.ensemblgenomes.org/id/AAC75352 EnsemblBacteria BAA16128 http://www.ensemblgenomes.org/id/BAA16128 EnsemblBacteria BAA16128 http://www.ensemblgenomes.org/id/BAA16128 EnsemblBacteria BAA16128 http://www.ensemblgenomes.org/id/BAA16128 EnsemblBacteria b2292 http://www.ensemblgenomes.org/id/b2292 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_function GO:0008324 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008324 GO_process GO:0006813 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813 GO_process GO:0098656 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098656 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 3.30.70.1450 http://www.cathdb.info/version/latest/superfamily/3.30.70.1450 GeneID 946766 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946766 HOGENOM HOG000281279 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000281279&db=HOGENOM6 InParanoid P0AFU2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFU2 IntAct P0AFU2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFU2* InterPro IPR004680 http://www.ebi.ac.uk/interpro/entry/IPR004680 InterPro IPR006037 http://www.ebi.ac.uk/interpro/entry/IPR006037 InterPro IPR031312 http://www.ebi.ac.uk/interpro/entry/IPR031312 KEGG_Gene ecj:JW2289 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2289 KEGG_Gene eco:b2292 http://www.genome.jp/dbget-bin/www_bget?eco:b2292 MINT MINT-1256616 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1256616 OMA GKIPLKF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GKIPLKF PROSITE PS01271 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01271 PROSITE PS51202 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51202 PSORT swissprot:YFBS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFBS_ECOLI PSORT-B swissprot:YFBS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFBS_ECOLI PSORT2 swissprot:YFBS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFBS_ECOLI Pfam PF02080 http://pfam.xfam.org/family/PF02080 Pfam PF03600 http://pfam.xfam.org/family/PF03600 Phobius swissprot:YFBS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFBS_ECOLI PhylomeDB P0AFU2 http://phylomedb.org/?seqid=P0AFU2 ProteinModelPortal P0AFU2 http://www.proteinmodelportal.org/query/uniprot/P0AFU2 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416795 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416795 RefSeq WP_001012899 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001012899 SMR P0AFU2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFU2 STRING 511145.b2292 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2292&targetmode=cogs SUPFAM SSF116726 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF116726 TCDB 2.A.47.4 http://www.tcdb.org/search/result.php?tc=2.A.47.4 UniProtKB YFBS_ECOLI http://www.uniprot.org/uniprot/YFBS_ECOLI UniProtKB-AC P0AFU2 http://www.uniprot.org/uniprot/P0AFU2 charge swissprot:YFBS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFBS_ECOLI eggNOG COG0471 http://eggnogapi.embl.de/nog_data/html/tree/COG0471 eggNOG ENOG4107QWE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QWE epestfind swissprot:YFBS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFBS_ECOLI garnier swissprot:YFBS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFBS_ECOLI helixturnhelix swissprot:YFBS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFBS_ECOLI hmoment swissprot:YFBS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFBS_ECOLI iep swissprot:YFBS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFBS_ECOLI inforesidue swissprot:YFBS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFBS_ECOLI octanol swissprot:YFBS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFBS_ECOLI pepcoil swissprot:YFBS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFBS_ECOLI pepdigest swissprot:YFBS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFBS_ECOLI pepinfo swissprot:YFBS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFBS_ECOLI pepnet swissprot:YFBS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFBS_ECOLI pepstats swissprot:YFBS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFBS_ECOLI pepwheel swissprot:YFBS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFBS_ECOLI pepwindow swissprot:YFBS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFBS_ECOLI sigcleave swissprot:YFBS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFBS_ECOLI ## Database ID URL or Descriptions # AltName RNI_ECOLI Enterobacter ribonuclease # BRENDA 3.1.27 2026 # BioGrid 4259901 6 # CATALYTIC ACTIVITY RNI_ECOLI Endonucleolytic cleavage to nucleoside 3'- phosphates and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates. # EcoGene EG10856 rna # FUNCTION RNI_ECOLI One of the few RNases that cleaves the phosphodiester bond between any two nucleotide. Shows a preference for cytidylic or guanylic acid. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_function GO:0003723 RNA binding; IEA:InterPro. # GO_function GO:0004519 endonuclease activity; IMP:EcoCyc. # GO_function GO:0008847 Enterobacter ribonuclease activity; IEA:UniProtKB-EC. # GO_function GO:0033897 ribonuclease T2 activity; IEA:InterPro. # GO_process GO:0006401 RNA catabolic process; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0004518 nuclease activity # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # Gene3D 3.90.730.10 -; 1. # InterPro IPR001568 RNase_T2-like # InterPro IPR018188 RNase_T2_His_AS_1 # InterPro IPR033130 RNase_T2_His_AS_2 # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # Organism RNI_ECOLI Escherichia coli (strain K12) # PATRIC 32116402 VBIEscCol129921_0641 # PDB 2EA1 X-ray; 1.80 A; A=24-268 # PDB 2PQX X-ray; 1.42 A; A=24-268 # PDB 2PQY X-ray; 2.30 A; A=24-268 # PDB 2Z70 X-ray; 1.70 A; A=24-268 # PIR JQ0777 JQ0777 # PROSITE PS00530 RNASE_T2_1 # PROSITE PS00531 RNASE_T2_2 # PTM RNI_ECOLI Contains four disulfide bonds. {ECO 0000250}. # Pfam PF00445 Ribonuclease_T2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RNI_ECOLI Ribonuclease I # RefSeq NP_415144 NC_000913.3 # RefSeq WP_000643397 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40811.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the RNase T2 family. {ECO 0000305}. # SUBCELLULAR LOCATION RNI_ECOLI Periplasm. Cytoplasm. Note=RNase I (periplasmic) and RNase I* (cytoplasmic) appear to be isoforms apparently encoded by the same gene. The cytoplasmic form is less active towards natural polymer RNA. # SUBUNIT RNI_ECOLI Monomer. # SUPFAM SSF55895 SSF55895 # eggNOG COG3719 LUCA # eggNOG ENOG4105KTS Bacteria BLAST swissprot:RNI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RNI_ECOLI BioCyc ECOL316407:JW0603-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0603-MONOMER BioCyc EcoCyc:EG10856-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10856-MONOMER BioCyc MetaCyc:EG10856-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10856-MONOMER COG COG3719 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3719 DOI 10.1006/geno.1994.1018 http://dx.doi.org/10.1006/geno.1994.1018 DOI 10.1016/0378-1119(90)90406-H http://dx.doi.org/10.1016/0378-1119(90)90406-H DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.27.6 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.27.6 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M55687 http://www.ebi.ac.uk/ena/data/view/M55687 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 ENZYME 3.1.27.6 http://enzyme.expasy.org/EC/3.1.27.6 EchoBASE EB0849 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0849 EcoGene EG10856 http://www.ecogene.org/geneInfo.php?eg_id=EG10856 EnsemblBacteria AAC73712 http://www.ensemblgenomes.org/id/AAC73712 EnsemblBacteria AAC73712 http://www.ensemblgenomes.org/id/AAC73712 EnsemblBacteria BAA35240 http://www.ensemblgenomes.org/id/BAA35240 EnsemblBacteria BAA35240 http://www.ensemblgenomes.org/id/BAA35240 EnsemblBacteria BAA35240 http://www.ensemblgenomes.org/id/BAA35240 EnsemblBacteria b0611 http://www.ensemblgenomes.org/id/b0611 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0004519 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004519 GO_function GO:0008847 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008847 GO_function GO:0033897 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033897 GO_process GO:0006401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006401 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 Gene3D 3.90.730.10 http://www.cathdb.info/version/latest/superfamily/3.90.730.10 GeneID 949065 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949065 HOGENOM HOG000117890 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117890&db=HOGENOM6 InParanoid P21338 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P21338 IntAct P21338 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P21338* IntEnz 3.1.27.6 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.27.6 InterPro IPR001568 http://www.ebi.ac.uk/interpro/entry/IPR001568 InterPro IPR018188 http://www.ebi.ac.uk/interpro/entry/IPR018188 InterPro IPR033130 http://www.ebi.ac.uk/interpro/entry/IPR033130 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW0603 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0603 KEGG_Gene eco:b0611 http://www.genome.jp/dbget-bin/www_bget?eco:b0611 KEGG_Orthology KO:K01169 http://www.genome.jp/dbget-bin/www_bget?KO:K01169 MINT MINT-1292710 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1292710 OMA TRPIPNM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TRPIPNM PDB 2EA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/2EA1 PDB 2PQX http://www.ebi.ac.uk/pdbe-srv/view/entry/2PQX PDB 2PQY http://www.ebi.ac.uk/pdbe-srv/view/entry/2PQY PDB 2Z70 http://www.ebi.ac.uk/pdbe-srv/view/entry/2Z70 PDBsum 2EA1 http://www.ebi.ac.uk/pdbsum/2EA1 PDBsum 2PQX http://www.ebi.ac.uk/pdbsum/2PQX PDBsum 2PQY http://www.ebi.ac.uk/pdbsum/2PQY PDBsum 2Z70 http://www.ebi.ac.uk/pdbsum/2Z70 PROSITE PS00530 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00530 PROSITE PS00531 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00531 PSORT swissprot:RNI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RNI_ECOLI PSORT-B swissprot:RNI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RNI_ECOLI PSORT2 swissprot:RNI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RNI_ECOLI Pfam PF00445 http://pfam.xfam.org/family/PF00445 Phobius swissprot:RNI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RNI_ECOLI ProteinModelPortal P21338 http://www.proteinmodelportal.org/query/uniprot/P21338 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2253883 http://www.ncbi.nlm.nih.gov/pubmed/2253883 PubMed 8188249 http://www.ncbi.nlm.nih.gov/pubmed/8188249 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415144 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415144 RefSeq WP_000643397 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000643397 SMR P21338 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P21338 STRING 511145.b0611 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0611&targetmode=cogs STRING COG3719 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3719&targetmode=cogs SUPFAM SSF55895 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55895 UniProtKB RNI_ECOLI http://www.uniprot.org/uniprot/RNI_ECOLI UniProtKB-AC P21338 http://www.uniprot.org/uniprot/P21338 charge swissprot:RNI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RNI_ECOLI eggNOG COG3719 http://eggnogapi.embl.de/nog_data/html/tree/COG3719 eggNOG ENOG4105KTS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KTS epestfind swissprot:RNI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RNI_ECOLI garnier swissprot:RNI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RNI_ECOLI helixturnhelix swissprot:RNI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RNI_ECOLI hmoment swissprot:RNI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RNI_ECOLI iep swissprot:RNI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RNI_ECOLI inforesidue swissprot:RNI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RNI_ECOLI octanol swissprot:RNI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RNI_ECOLI pepcoil swissprot:RNI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RNI_ECOLI pepdigest swissprot:RNI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RNI_ECOLI pepinfo swissprot:RNI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RNI_ECOLI pepnet swissprot:RNI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RNI_ECOLI pepstats swissprot:RNI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RNI_ECOLI pepwheel swissprot:RNI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RNI_ECOLI pepwindow swissprot:RNI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RNI_ECOLI sigcleave swissprot:RNI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RNI_ECOLI ## Database ID URL or Descriptions # BioGrid 4259793 6 # CDD cd06170 LuxR_C_like # EcoGene EG14324 ecpR # FUNCTION ECPR_ECOLI Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition. Positively regulates the expression of the ecp operon (By similarity). Also represses expression of the flagellar master operon flhDC, and consequently prevents flagellum biosynthesis and motility. Acts by binding to the regulatory region of the flhDC operon (Probable). {ECO 0000250, ECO 0000269|PubMed 22422754, ECO 0000305}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # INDUCTION Negatively regulated by H-NS. Positively autoregulated. Also positively regulated by IHF (By similarity). {ECO 0000250}. # InterPro IPR000792 Tscrpt_reg_LuxR_C # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR016032 Sig_transdc_resp-reg_C-effctor # MISCELLANEOUS Expressed in strain K12. {ECO:0000305|PubMed 11466275}. # Organism ECPR_ECOLI Escherichia coli (strain K12) # PATRIC 32115711 VBIEscCol129921_0298 # PIR F64755 F64755 # PRINTS PR00038 HTHLUXR # PROSITE PS50043 HTH_LUXR_2 # Pfam PF00196 GerE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ECPR_ECOLI HTH-type transcriptional regulator EcpR # RefSeq NP_414828 NC_000913.3 # SIMILARITY Belongs to the EcpR/MatA family. {ECO 0000305}. # SIMILARITY Contains 1 HTH luxR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00411}. # SMART SM00421 HTH_LUXR # SUBCELLULAR LOCATION ECPR_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF46894 SSF46894 # eggNOG ENOG4106JB4 Bacteria # eggNOG ENOG410Y9ZI LUCA BLAST swissprot:ECPR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ECPR_ECOLI BioCyc ECOL316407:JW5031-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5031-MONOMER BioCyc EcoCyc:G6165-MONOMER http://biocyc.org/getid?id=EcoCyc:G6165-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1099/mic.0.056499-0 http://dx.doi.org/10.1099/mic.0.056499-0 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.183.16.4727-4736.2001 http://dx.doi.org/10.1128/JB.183.16.4727-4736.2001 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB4070 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4070 EcoGene EG14324 http://www.ecogene.org/geneInfo.php?eg_id=EG14324 EnsemblBacteria AAC73397 http://www.ensemblgenomes.org/id/AAC73397 EnsemblBacteria AAC73397 http://www.ensemblgenomes.org/id/AAC73397 EnsemblBacteria BAE76078 http://www.ensemblgenomes.org/id/BAE76078 EnsemblBacteria BAE76078 http://www.ensemblgenomes.org/id/BAE76078 EnsemblBacteria BAE76078 http://www.ensemblgenomes.org/id/BAE76078 EnsemblBacteria b0294 http://www.ensemblgenomes.org/id/b0294 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 944966 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944966 HOGENOM HOG000059412 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000059412&db=HOGENOM6 IntAct P71301 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P71301* InterPro IPR000792 http://www.ebi.ac.uk/interpro/entry/IPR000792 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR016032 http://www.ebi.ac.uk/interpro/entry/IPR016032 KEGG_Gene ecj:JW5031 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5031 KEGG_Gene eco:b0294 http://www.genome.jp/dbget-bin/www_bget?eco:b0294 OMA CIWPAHD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CIWPAHD PRINTS PR00038 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00038 PROSITE PS50043 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50043 PSORT swissprot:ECPR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ECPR_ECOLI PSORT-B swissprot:ECPR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ECPR_ECOLI PSORT2 swissprot:ECPR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ECPR_ECOLI Pfam PF00196 http://pfam.xfam.org/family/PF00196 Phobius swissprot:ECPR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ECPR_ECOLI ProteinModelPortal P71301 http://www.proteinmodelportal.org/query/uniprot/P71301 PubMed 11466275 http://www.ncbi.nlm.nih.gov/pubmed/11466275 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22422754 http://www.ncbi.nlm.nih.gov/pubmed/22422754 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414828 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414828 SMART SM00421 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00421 SMR P71301 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P71301 STRING 511145.b0294 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0294&targetmode=cogs SUPFAM SSF46894 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46894 UniProtKB ECPR_ECOLI http://www.uniprot.org/uniprot/ECPR_ECOLI UniProtKB-AC P71301 http://www.uniprot.org/uniprot/P71301 charge swissprot:ECPR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ECPR_ECOLI eggNOG ENOG4106JB4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106JB4 eggNOG ENOG410Y9ZI http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y9ZI epestfind swissprot:ECPR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ECPR_ECOLI garnier swissprot:ECPR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ECPR_ECOLI helixturnhelix swissprot:ECPR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ECPR_ECOLI hmoment swissprot:ECPR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ECPR_ECOLI iep swissprot:ECPR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ECPR_ECOLI inforesidue swissprot:ECPR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ECPR_ECOLI octanol swissprot:ECPR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ECPR_ECOLI pepcoil swissprot:ECPR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ECPR_ECOLI pepdigest swissprot:ECPR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ECPR_ECOLI pepinfo swissprot:ECPR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ECPR_ECOLI pepnet swissprot:ECPR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ECPR_ECOLI pepstats swissprot:ECPR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ECPR_ECOLI pepwheel swissprot:ECPR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ECPR_ECOLI pepwindow swissprot:ECPR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ECPR_ECOLI sigcleave swissprot:ECPR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ECPR_ECOLI ## Database ID URL or Descriptions # AltName Murein lyase C {ECO:0000255|HAMAP-Rule MF_01616} # BioGrid 4262361 451 # CATALYTIC ACTIVITY Exolytic cleavage of the (1->4)-beta- glycosidic linkage between N-acetylmuramic acid (MurNAc) and N- acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue. {ECO:0000255|HAMAP-Rule MF_01616}. # CAZy GH23 Glycoside Hydrolase Family 23 # EcoGene EG12986 mltC # FUNCTION MLTC_ECOLI Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. {ECO 0000255|HAMAP-Rule MF_01616}. # GO_component GO:0009279 cell outer membrane; IEA:UniProtKB-SubCell. # GO_function GO:0008933 lytic transglycosylase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0016798 hydrolase activity, acting on glycosyl bonds; IEA:InterPro. # GO_function GO:0052762 gellan lyase activity; IEA:UniProtKB-EC. # GO_function GO:0052764 exo-oligoalginate lyase activity; IEA:UniProtKB-EC. # GO_process GO:0000270 peptidoglycan metabolic process; IEA:InterPro. # GO_process GO:0016998 cell wall macromolecule catabolic process; IEA:UniProtKB-HAMAP. # GO_process GO:0034599 cellular response to oxidative stress; IEP:EcoCyc. # GO_process GO:0071236 cellular response to antibiotic; IMP:EcoCyc. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0071554 cell wall organization or biogenesis # HAMAP MF_01616 MltC # INDUCTION By SoxS. {ECO:0000269|PubMed 14594836}. # InterPro IPR000189 Transglyc_AS # InterPro IPR008258 Transglycosylase_SLT_dom_1 # InterPro IPR023346 Lysozyme-like_dom # InterPro IPR023664 Murein_transglycosylaseC # InterPro IPR024570 Murein_transglycosylaseC_N # KEGG_Brite ko01000 Enzymes # Organism MLTC_ECOLI Escherichia coli (strain K12) # PATRIC 32121340 VBIEscCol129921_3058 # PDB 4C5F X-ray; 2.34 A; A/B=20-359 # PDB 4CFO X-ray; 2.90 A; A/B=20-359 # PDB 4CFP X-ray; 2.15 A; A/B=20-359 # PDB 4CHX X-ray; 2.45 A; A/B=20-359 # PIR B65082 B65082 # PROSITE PS00922 TRANSGLYCOSYLASE # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF01464 SLT # Pfam PF11873 DUF3393 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Membrane-bound lytic murein transglycosylase C {ECO:0000255|HAMAP-Rule MF_01616} # RefSeq NP_417438 NC_000913.3 # RefSeq WP_000760323 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA69130.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAA69130.1; Type=Frameshift; Positions=166; Evidence={ECO 0000305}; Sequence=AAA69131.1; Type=Frameshift; Positions=166; Evidence={ECO:0000305}; # SIMILARITY Belongs to the transglycosylase Slt family. {ECO:0000255|HAMAP-Rule MF_01616}. # SUBCELLULAR LOCATION MLTC_ECOLI Cell outer membrane {ECO 0000305}; Lipid- anchor {ECO 0000305}. # SUPFAM SSF53955 SSF53955 # eggNOG COG0741 LUCA # eggNOG ENOG4106S48 Bacteria BLAST swissprot:MLTC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MLTC_ECOLI BioCyc ECOL316407:JW5481-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5481-MONOMER BioCyc EcoCyc:G7533-MONOMER http://biocyc.org/getid?id=EcoCyc:G7533-MONOMER BioCyc MetaCyc:G7533-MONOMER http://biocyc.org/getid?id=MetaCyc:G7533-MONOMER COG COG0741 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0741 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1089/mdr.1996.2.141 http://dx.doi.org/10.1089/mdr.1996.2.141 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.185.22.6624-6632.2003 http://dx.doi.org/10.1128/JB.185.22.6624-6632.2003 EC_number EC:4.2.2.n1 {ECO:0000255|HAMAP-Rule:MF_01616} http://www.genome.jp/dbget-bin/www_bget?EC:4.2.2.n1 {ECO:0000255|HAMAP-Rule:MF_01616} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EMBL U59902 http://www.ebi.ac.uk/ena/data/view/U59902 ENZYME 4.2.2.n1 {ECO:0000255|HAMAP-Rule:MF_01616} http://enzyme.expasy.org/EC/4.2.2.n1 {ECO:0000255|HAMAP-Rule:MF_01616} EchoBASE EB2810 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2810 EcoGene EG12986 http://www.ecogene.org/geneInfo.php?eg_id=EG12986 EnsemblBacteria AAC76000 http://www.ensemblgenomes.org/id/AAC76000 EnsemblBacteria AAC76000 http://www.ensemblgenomes.org/id/AAC76000 EnsemblBacteria BAE77026 http://www.ensemblgenomes.org/id/BAE77026 EnsemblBacteria BAE77026 http://www.ensemblgenomes.org/id/BAE77026 EnsemblBacteria BAE77026 http://www.ensemblgenomes.org/id/BAE77026 EnsemblBacteria b2963 http://www.ensemblgenomes.org/id/b2963 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_function GO:0008933 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008933 GO_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GO_function GO:0052762 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052762 GO_function GO:0052764 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052764 GO_process GO:0000270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000270 GO_process GO:0016998 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016998 GO_process GO:0034599 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034599 GO_process GO:0071236 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071236 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 GeneID 945428 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945428 HAMAP MF_01616 http://hamap.expasy.org/unirule/MF_01616 HOGENOM HOG000283572 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000283572&db=HOGENOM6 IntEnz 4.2.2.n1 {ECO:0000255|HAMAP-Rule:MF_01616} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.2.n1 {ECO:0000255|HAMAP-Rule:MF_01616} InterPro IPR000189 http://www.ebi.ac.uk/interpro/entry/IPR000189 InterPro IPR008258 http://www.ebi.ac.uk/interpro/entry/IPR008258 InterPro IPR023346 http://www.ebi.ac.uk/interpro/entry/IPR023346 InterPro IPR023664 http://www.ebi.ac.uk/interpro/entry/IPR023664 InterPro IPR024570 http://www.ebi.ac.uk/interpro/entry/IPR024570 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5481 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5481 KEGG_Gene eco:b2963 http://www.genome.jp/dbget-bin/www_bget?eco:b2963 KEGG_Orthology KO:K08306 http://www.genome.jp/dbget-bin/www_bget?KO:K08306 OMA AIMQIES http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AIMQIES PDB 4C5F http://www.ebi.ac.uk/pdbe-srv/view/entry/4C5F PDB 4CFO http://www.ebi.ac.uk/pdbe-srv/view/entry/4CFO PDB 4CFP http://www.ebi.ac.uk/pdbe-srv/view/entry/4CFP PDB 4CHX http://www.ebi.ac.uk/pdbe-srv/view/entry/4CHX PDBsum 4C5F http://www.ebi.ac.uk/pdbsum/4C5F PDBsum 4CFO http://www.ebi.ac.uk/pdbsum/4CFO PDBsum 4CFP http://www.ebi.ac.uk/pdbsum/4CFP PDBsum 4CHX http://www.ebi.ac.uk/pdbsum/4CHX PROSITE PS00922 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00922 PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:MLTC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MLTC_ECOLI PSORT-B swissprot:MLTC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MLTC_ECOLI PSORT2 swissprot:MLTC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MLTC_ECOLI Pfam PF01464 http://pfam.xfam.org/family/PF01464 Pfam PF11873 http://pfam.xfam.org/family/PF11873 Phobius swissprot:MLTC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MLTC_ECOLI ProteinModelPortal P0C066 http://www.proteinmodelportal.org/query/uniprot/P0C066 PubMed 14594836 http://www.ncbi.nlm.nih.gov/pubmed/14594836 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9158737 http://www.ncbi.nlm.nih.gov/pubmed/9158737 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417438 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417438 RefSeq WP_000760323 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000760323 SMR P0C066 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0C066 STRING 511145.b2963 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2963&targetmode=cogs STRING COG0741 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0741&targetmode=cogs SUPFAM SSF53955 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53955 UniProtKB MLTC_ECOLI http://www.uniprot.org/uniprot/MLTC_ECOLI UniProtKB-AC P0C066 http://www.uniprot.org/uniprot/P0C066 charge swissprot:MLTC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MLTC_ECOLI eggNOG COG0741 http://eggnogapi.embl.de/nog_data/html/tree/COG0741 eggNOG ENOG4106S48 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106S48 epestfind swissprot:MLTC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MLTC_ECOLI garnier swissprot:MLTC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MLTC_ECOLI helixturnhelix swissprot:MLTC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MLTC_ECOLI hmoment swissprot:MLTC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MLTC_ECOLI iep swissprot:MLTC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MLTC_ECOLI inforesidue swissprot:MLTC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MLTC_ECOLI octanol swissprot:MLTC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MLTC_ECOLI pepcoil swissprot:MLTC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MLTC_ECOLI pepdigest swissprot:MLTC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MLTC_ECOLI pepinfo swissprot:MLTC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MLTC_ECOLI pepnet swissprot:MLTC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MLTC_ECOLI pepstats swissprot:MLTC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MLTC_ECOLI pepwheel swissprot:MLTC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MLTC_ECOLI pepwindow swissprot:MLTC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MLTC_ECOLI sigcleave swissprot:MLTC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MLTC_ECOLI ## Database ID URL or Descriptions # BioGrid 4261234 16 # EcoGene EG11192 yicC # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # IntAct P23839 12 # InterPro IPR005229 CHP00255 # InterPro IPR013527 YicC-like_N # InterPro IPR013551 DUF1732 # MISCELLANEOUS YICC_ECOLI Essential for E.coli under special growth condition. # Organism YICC_ECOLI Escherichia coli (strain K12) # PATRIC 32122775 VBIEscCol129921_3764 # PIR F65165 F65165 # Pfam PF03755 YicC_N # Pfam PF08340 DUF1732 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YICC_ECOLI UPF0701 protein YicC # RefSeq NP_418101 NC_000913.3 # RefSeq WP_000621340 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0701 family. {ECO 0000305}. # TIGRFAMs TIGR00255 TIGR00255 # eggNOG COG1561 LUCA # eggNOG ENOG4105DSJ Bacteria BLAST swissprot:YICC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YICC_ECOLI BioCyc ECOL316407:JW3619-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3619-MONOMER BioCyc EcoCyc:EG11192-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11192-MONOMER DIP DIP-12428N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12428N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1016/0923-2508(91)90042-9 http://dx.doi.org/10.1016/0923-2508(91)90042-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1989.tb00184.x http://dx.doi.org/10.1111/j.1365-2958.1989.tb00184.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X14235 http://www.ebi.ac.uk/ena/data/view/X14235 EchoBASE EB1178 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1178 EcoGene EG11192 http://www.ecogene.org/geneInfo.php?eg_id=EG11192 EnsemblBacteria AAC76668 http://www.ensemblgenomes.org/id/AAC76668 EnsemblBacteria AAC76668 http://www.ensemblgenomes.org/id/AAC76668 EnsemblBacteria BAE77649 http://www.ensemblgenomes.org/id/BAE77649 EnsemblBacteria BAE77649 http://www.ensemblgenomes.org/id/BAE77649 EnsemblBacteria BAE77649 http://www.ensemblgenomes.org/id/BAE77649 EnsemblBacteria b3644 http://www.ensemblgenomes.org/id/b3644 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GeneID 948154 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948154 HOGENOM HOG000037752 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000037752&db=HOGENOM6 InParanoid P23839 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23839 IntAct P23839 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P23839* InterPro IPR005229 http://www.ebi.ac.uk/interpro/entry/IPR005229 InterPro IPR013527 http://www.ebi.ac.uk/interpro/entry/IPR013527 InterPro IPR013551 http://www.ebi.ac.uk/interpro/entry/IPR013551 KEGG_Gene ecj:JW3619 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3619 KEGG_Gene eco:b3644 http://www.genome.jp/dbget-bin/www_bget?eco:b3644 MINT MINT-1230449 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1230449 OMA QEMILLA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QEMILLA PSORT swissprot:YICC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YICC_ECOLI PSORT-B swissprot:YICC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YICC_ECOLI PSORT2 swissprot:YICC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YICC_ECOLI Pfam PF03755 http://pfam.xfam.org/family/PF03755 Pfam PF08340 http://pfam.xfam.org/family/PF08340 Phobius swissprot:YICC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YICC_ECOLI PhylomeDB P23839 http://phylomedb.org/?seqid=P23839 ProteinModelPortal P23839 http://www.proteinmodelportal.org/query/uniprot/P23839 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1925027 http://www.ncbi.nlm.nih.gov/pubmed/1925027 PubMed 2664418 http://www.ncbi.nlm.nih.gov/pubmed/2664418 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_418101 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418101 RefSeq WP_000621340 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000621340 SMR P23839 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P23839 STRING 511145.b3644 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3644&targetmode=cogs TIGRFAMs TIGR00255 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00255 UniProtKB YICC_ECOLI http://www.uniprot.org/uniprot/YICC_ECOLI UniProtKB-AC P23839 http://www.uniprot.org/uniprot/P23839 charge swissprot:YICC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YICC_ECOLI eggNOG COG1561 http://eggnogapi.embl.de/nog_data/html/tree/COG1561 eggNOG ENOG4105DSJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DSJ epestfind swissprot:YICC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YICC_ECOLI garnier swissprot:YICC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YICC_ECOLI helixturnhelix swissprot:YICC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YICC_ECOLI hmoment swissprot:YICC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YICC_ECOLI iep swissprot:YICC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YICC_ECOLI inforesidue swissprot:YICC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YICC_ECOLI octanol swissprot:YICC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YICC_ECOLI pepcoil swissprot:YICC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YICC_ECOLI pepdigest swissprot:YICC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YICC_ECOLI pepinfo swissprot:YICC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YICC_ECOLI pepnet swissprot:YICC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YICC_ECOLI pepstats swissprot:YICC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YICC_ECOLI pepwheel swissprot:YICC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YICC_ECOLI pepwindow swissprot:YICC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YICC_ECOLI sigcleave swissprot:YICC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YICC_ECOLI ## Database ID URL or Descriptions # BioGrid 4261378 5 # EcoGene EG13652 djlC # GO_function GO:0001671 ATPase activator activity; IDA:EcoCyc. # GOslim_function GO:0030234 enzyme regulator activity # IntAct P77359 2 # InterPro IPR001623 DnaJ_domain # Organism DJLC_ECOLI Escherichia coli (strain K12) # PATRIC 32116481 VBIEscCol129921_0680 # PIR G64799 G64799 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DJLC_ECOLI Uncharacterized J domain-containing protein DjlC # RefSeq NP_415182 NC_000913.3 # RefSeq WP_001300403 NZ_LN832404.1 # SIMILARITY Contains 1 J domain. {ECO 0000305}. # SUPFAM SSF46565 SSF46565 # eggNOG ENOG4105QFC Bacteria # eggNOG ENOG4111WD0 LUCA BLAST swissprot:DJLC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DJLC_ECOLI BioCyc ECOL316407:JW0644-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0644-MONOMER BioCyc EcoCyc:G6356-MONOMER http://biocyc.org/getid?id=EcoCyc:G6356-MONOMER BioCyc MetaCyc:G6356-MONOMER http://biocyc.org/getid?id=MetaCyc:G6356-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB3416 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3416 EcoGene EG13652 http://www.ecogene.org/geneInfo.php?eg_id=EG13652 EnsemblBacteria AAC73750 http://www.ensemblgenomes.org/id/AAC73750 EnsemblBacteria AAC73750 http://www.ensemblgenomes.org/id/AAC73750 EnsemblBacteria BAA35296 http://www.ensemblgenomes.org/id/BAA35296 EnsemblBacteria BAA35296 http://www.ensemblgenomes.org/id/BAA35296 EnsemblBacteria BAA35296 http://www.ensemblgenomes.org/id/BAA35296 EnsemblBacteria b0649 http://www.ensemblgenomes.org/id/b0649 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0001671 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001671 GOslim_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 GeneID 945253 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945253 HOGENOM HOG000009369 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009369&db=HOGENOM6 IntAct P77359 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77359* InterPro IPR001623 http://www.ebi.ac.uk/interpro/entry/IPR001623 KEGG_Gene ecj:JW0644 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0644 KEGG_Gene eco:b0649 http://www.genome.jp/dbget-bin/www_bget?eco:b0649 OMA QACPLEA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QACPLEA PSORT swissprot:DJLC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DJLC_ECOLI PSORT-B swissprot:DJLC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DJLC_ECOLI PSORT2 swissprot:DJLC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DJLC_ECOLI Phobius swissprot:DJLC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DJLC_ECOLI ProteinModelPortal P77359 http://www.proteinmodelportal.org/query/uniprot/P77359 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415182 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415182 RefSeq WP_001300403 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300403 SMR P77359 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77359 STRING 511145.b0649 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0649&targetmode=cogs SUPFAM SSF46565 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46565 UniProtKB DJLC_ECOLI http://www.uniprot.org/uniprot/DJLC_ECOLI UniProtKB-AC P77359 http://www.uniprot.org/uniprot/P77359 charge swissprot:DJLC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DJLC_ECOLI eggNOG ENOG4105QFC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105QFC eggNOG ENOG4111WD0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111WD0 epestfind swissprot:DJLC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DJLC_ECOLI garnier swissprot:DJLC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DJLC_ECOLI helixturnhelix swissprot:DJLC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DJLC_ECOLI hmoment swissprot:DJLC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DJLC_ECOLI iep swissprot:DJLC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DJLC_ECOLI inforesidue swissprot:DJLC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DJLC_ECOLI octanol swissprot:DJLC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DJLC_ECOLI pepcoil swissprot:DJLC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DJLC_ECOLI pepdigest swissprot:DJLC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DJLC_ECOLI pepinfo swissprot:DJLC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DJLC_ECOLI pepnet swissprot:DJLC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DJLC_ECOLI pepstats swissprot:DJLC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DJLC_ECOLI pepwheel swissprot:DJLC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DJLC_ECOLI pepwindow swissprot:DJLC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DJLC_ECOLI sigcleave swissprot:DJLC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DJLC_ECOLI ## Database ID URL or Descriptions # AltName EFEU_ECOLI Putative Fe(2+) ion permease EfeU # CAUTION Could be the product of a pseudogene. Strain K12 contains a truncated, inactive permease due to a frameshift in position 34 that produces two separate ORFs. The sequence shown here is a reconstruction originating from EcoGene. {ECO 0000305}. # EcoGene EG13860 efeU # GO_component GO:0005886 plasma membrane; IBA:GO_Central. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_component GO:0033573 high-affinity iron permease complex; IEA:InterPro. # GO_function GO:0015639 ferrous iron uptake transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0006827 high-affinity iron ion transmembrane transport; IBA:GO_Central. # GO_process GO:0015684 ferrous iron transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # InterPro IPR004923 FTR1/Fip1/EfeU # InterPro IPR005217 FTR1-like # Organism EFEU_ECOLI Escherichia coli (strain K12) # PANTHER PTHR31632 PTHR31632 # Pfam PF03239 FTR1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EFEU_ECOLI Putative inactive ferrous iron permease EfeU # SEQUENCE CAUTION Sequence=AP009048; Type=Frameshift; Positions=34; Evidence={ECO:0000305}; Sequence=U00096; Type=Frameshift; Positions=34; Evidence={ECO 0000305}; # SIMILARITY Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family. {ECO 0000305}. # SUBCELLULAR LOCATION EFEU_ECOLI Cell inner membrane {ECO 0000250}; Multi- pass membrane protein {ECO 0000250}. # SUBUNIT Part of a ferrous iron transporter composed of EfeU, EfeO and EfeB. However, this EfeUOB tripartite iron transporter is defective in E.coli strain K12 due to a frameshift mutation in EfeU. {ECO:0000269|PubMed 17627767}. # TCDB 2.A.108.2 the iron/lead transporter (ilt) family # TIGRFAMs TIGR00145 TIGR00145 BLAST swissprot:EFEU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EFEU_ECOLI BioCyc EcoCyc:G6525-MONOMER http://biocyc.org/getid?id=EcoCyc:G6525-MONOMER BioCyc MetaCyc:G6525-MONOMER http://biocyc.org/getid?id=MetaCyc:G6525-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.2007.05802.x http://dx.doi.org/10.1111/j.1365-2958.2007.05802.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3620 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3620 EcoGene EG13860 http://www.ecogene.org/geneInfo.php?eg_id=EG13860 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0033573 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033573 GO_function GO:0015639 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015639 GO_process GO:0006827 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006827 GO_process GO:0015684 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015684 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 HOGENOM HOG000236918 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000236918&db=HOGENOM6 InParanoid P75901 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75901 InterPro IPR004923 http://www.ebi.ac.uk/interpro/entry/IPR004923 InterPro IPR005217 http://www.ebi.ac.uk/interpro/entry/IPR005217 PANTHER PTHR31632 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31632 PSORT swissprot:EFEU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EFEU_ECOLI PSORT-B swissprot:EFEU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EFEU_ECOLI PSORT2 swissprot:EFEU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EFEU_ECOLI Pfam PF03239 http://pfam.xfam.org/family/PF03239 Phobius swissprot:EFEU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EFEU_ECOLI PhylomeDB P75901 http://phylomedb.org/?seqid=P75901 ProteinModelPortal P75901 http://www.proteinmodelportal.org/query/uniprot/P75901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17627767 http://www.ncbi.nlm.nih.gov/pubmed/17627767 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 TCDB 2.A.108.2 http://www.tcdb.org/search/result.php?tc=2.A.108.2 TIGRFAMs TIGR00145 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00145 UniProtKB EFEU_ECOLI http://www.uniprot.org/uniprot/EFEU_ECOLI UniProtKB-AC P75901 http://www.uniprot.org/uniprot/P75901 charge swissprot:EFEU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EFEU_ECOLI epestfind swissprot:EFEU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EFEU_ECOLI garnier swissprot:EFEU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EFEU_ECOLI helixturnhelix swissprot:EFEU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EFEU_ECOLI hmoment swissprot:EFEU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EFEU_ECOLI iep swissprot:EFEU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EFEU_ECOLI inforesidue swissprot:EFEU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EFEU_ECOLI octanol swissprot:EFEU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EFEU_ECOLI pepcoil swissprot:EFEU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EFEU_ECOLI pepdigest swissprot:EFEU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EFEU_ECOLI pepinfo swissprot:EFEU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EFEU_ECOLI pepnet swissprot:EFEU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EFEU_ECOLI pepstats swissprot:EFEU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EFEU_ECOLI pepwheel swissprot:EFEU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EFEU_ECOLI pepwindow swissprot:EFEU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EFEU_ECOLI sigcleave swissprot:EFEU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EFEU_ECOLI ## Database ID URL or Descriptions # AltName FABA_ECOLI 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA # AltName FABA_ECOLI Beta-hydroxydecanoyl thioester dehydrase # AltName FABA_ECOLI Trans-2-decenoyl-[acyl-carrier-protein] isomerase # BRENDA 5.3.3.14 2026 # BioGrid 4263239 209 # CATALYTIC ACTIVITY (3R)-3-hydroxydecanoyl-[acyl-carrier-protein] = trans-dec-2-enoyl-[acyl-carrier-protein] + H(2)O. {ECO:0000269|PubMed 8910376}. # CATALYTIC ACTIVITY A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H(2)O. {ECO:0000269|PubMed 8910376}. # CATALYTIC ACTIVITY Trans-dec-2-enoyl-[acyl-carrier-protein] = cis-dec-3-enoyl-[acyl-carrier-protein]. {ECO:0000269|PubMed 8910376}. # CDD cd01287 FabA # ENZYME REGULATION Irreversibly inactivated by 3-decynoyl-N- acetylcysteamine (DNAC) which binds to the active site and forms an adduct (PubMed:21276098). {ECO 0000305|PubMed:21276098}. # EcoGene EG10273 fabA # FUNCTION FABA_ECOLI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length. Is inactive in the dehydration of long chain unsaturated beta-hydroxyacyl-ACP. {ECO 0000269|PubMed 8910376}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008693 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity; IDA:EcoCyc. # GO_function GO:0034017 trans-2-decenoyl-acyl-carrier-protein isomerase activity; IDA:EcoCyc. # GO_function GO:0047451 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity; IDA:EcoCyc. # GO_process GO:0006633 fatty acid biosynthetic process; IMP:EcoCyc. # GO_process GO:0008610 lipid biosynthetic process; IGI:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.10.129.10 -; 1. # HAMAP MF_00405 FabA # INDUCTION FABA_ECOLI Mainly activated by FadR, but minor repression is also conferred by FabR (PubMed 11859088, PubMed 21276098). {ECO 0000269|PubMed 11859088, ECO 0000269|PubMed 21276098}. # IntAct P0A6Q3 29 # InterPro IPR010083 FabA # InterPro IPR013114 FabA_FabZ # InterPro IPR029069 HotDog_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01004 Lipid biosynthesis proteins # KEGG_Pathway ko00061 Fatty acid biosynthesis # Organism FABA_ECOLI Escherichia coli (strain K12) # PATHWAY FABA_ECOLI Lipid metabolism; fatty acid biosynthesis. # PATRIC 32117127 VBIEscCol129921_0988 # PDB 1MKA X-ray; 2.00 A; A/B=2-172 # PDB 1MKB X-ray; 2.00 A; A/B=2-172 # PDB 4KEH X-ray; 1.90 A; A/B=2-172 # PIR A64836 DWECHD # Pfam PF07977 FabA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FABA_ECOLI 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase # RefSeq NP_415474 NC_000913.3 # RefSeq WP_000227927 NZ_LN832404.1 # SIMILARITY Belongs to the thioester dehydratase family. FabA subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION FABA_ECOLI Cytoplasm. # SUBUNIT FABA_ECOLI Homodimer. # SUPFAM SSF54637 SSF54637 # TIGRFAMs TIGR01749 fabA # eggNOG COG0764 LUCA # eggNOG ENOG4108RKI Bacteria BLAST swissprot:FABA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FABA_ECOLI BioCyc ECOL316407:JW0937-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0937-MONOMER BioCyc EcoCyc:FABA-MONOMER http://biocyc.org/getid?id=EcoCyc:FABA-MONOMER BioCyc MetaCyc:FABA-MONOMER http://biocyc.org/getid?id=MetaCyc:FABA-MONOMER COG COG0764 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0764 DIP DIP-31864N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31864N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0092-8674(92)90435-F http://dx.doi.org/10.1016/0092-8674(92)90435-F DOI 10.1016/S0969-2126(96)00030-5 http://dx.doi.org/10.1016/S0969-2126(96)00030-5 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.271.44.27795 http://dx.doi.org/10.1074/jbc.271.44.27795 DOI 10.1074/jbc.M201399200 http://dx.doi.org/10.1074/jbc.M201399200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.2011.07564.x http://dx.doi.org/10.1111/j.1365-2958.2011.07564.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.1.59 http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.59 EC_number EC:5.3.3.14 http://www.genome.jp/dbget-bin/www_bget?EC:5.3.3.14 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J03186 http://www.ebi.ac.uk/ena/data/view/J03186 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U37057 http://www.ebi.ac.uk/ena/data/view/U37057 EMBL U56977 http://www.ebi.ac.uk/ena/data/view/U56977 ENZYME 4.2.1.59 http://enzyme.expasy.org/EC/4.2.1.59 ENZYME 5.3.3.14 http://enzyme.expasy.org/EC/5.3.3.14 EchoBASE EB0269 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0269 EcoGene EG10273 http://www.ecogene.org/geneInfo.php?eg_id=EG10273 EnsemblBacteria AAC74040 http://www.ensemblgenomes.org/id/AAC74040 EnsemblBacteria AAC74040 http://www.ensemblgenomes.org/id/AAC74040 EnsemblBacteria BAA35712 http://www.ensemblgenomes.org/id/BAA35712 EnsemblBacteria BAA35712 http://www.ensemblgenomes.org/id/BAA35712 EnsemblBacteria BAA35712 http://www.ensemblgenomes.org/id/BAA35712 EnsemblBacteria b0954 http://www.ensemblgenomes.org/id/b0954 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008693 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008693 GO_function GO:0034017 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034017 GO_function GO:0047451 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047451 GO_process GO:0006633 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006633 GO_process GO:0008610 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008610 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.10.129.10 http://www.cathdb.info/version/latest/superfamily/3.10.129.10 GeneID 945568 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945568 HAMAP MF_00405 http://hamap.expasy.org/unirule/MF_00405 HOGENOM HOG000277828 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000277828&db=HOGENOM6 InParanoid P0A6Q3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6Q3 IntAct P0A6Q3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6Q3* IntEnz 4.2.1.59 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.59 IntEnz 5.3.3.14 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.3.3.14 InterPro IPR010083 http://www.ebi.ac.uk/interpro/entry/IPR010083 InterPro IPR013114 http://www.ebi.ac.uk/interpro/entry/IPR013114 InterPro IPR029069 http://www.ebi.ac.uk/interpro/entry/IPR029069 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01004 http://www.genome.jp/dbget-bin/www_bget?ko01004 KEGG_Gene ecj:JW0937 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0937 KEGG_Gene eco:b0954 http://www.genome.jp/dbget-bin/www_bget?eco:b0954 KEGG_Orthology KO:K01716 http://www.genome.jp/dbget-bin/www_bget?KO:K01716 KEGG_Pathway ko00061 http://www.genome.jp/kegg-bin/show_pathway?ko00061 KEGG_Reaction rn:R04428 http://www.genome.jp/dbget-bin/www_bget?rn:R04428 KEGG_Reaction rn:R04535 http://www.genome.jp/dbget-bin/www_bget?rn:R04535 KEGG_Reaction rn:R04537 http://www.genome.jp/dbget-bin/www_bget?rn:R04537 KEGG_Reaction rn:R04544 http://www.genome.jp/dbget-bin/www_bget?rn:R04544 KEGG_Reaction rn:R04568 http://www.genome.jp/dbget-bin/www_bget?rn:R04568 KEGG_Reaction rn:R04954 http://www.genome.jp/dbget-bin/www_bget?rn:R04954 KEGG_Reaction rn:R04965 http://www.genome.jp/dbget-bin/www_bget?rn:R04965 MINT MINT-1218658 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1218658 OMA FFDCHFK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FFDCHFK PDB 1MKA http://www.ebi.ac.uk/pdbe-srv/view/entry/1MKA PDB 1MKB http://www.ebi.ac.uk/pdbe-srv/view/entry/1MKB PDB 4KEH http://www.ebi.ac.uk/pdbe-srv/view/entry/4KEH PDBsum 1MKA http://www.ebi.ac.uk/pdbsum/1MKA PDBsum 1MKB http://www.ebi.ac.uk/pdbsum/1MKB PDBsum 4KEH http://www.ebi.ac.uk/pdbsum/4KEH PSORT swissprot:FABA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FABA_ECOLI PSORT-B swissprot:FABA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FABA_ECOLI PSORT2 swissprot:FABA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FABA_ECOLI Pfam PF07977 http://pfam.xfam.org/family/PF07977 Phobius swissprot:FABA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FABA_ECOLI PhylomeDB P0A6Q3 http://phylomedb.org/?seqid=P0A6Q3 ProteinModelPortal P0A6Q3 http://www.proteinmodelportal.org/query/uniprot/P0A6Q3 PubMed 11859088 http://www.ncbi.nlm.nih.gov/pubmed/11859088 PubMed 1505031 http://www.ncbi.nlm.nih.gov/pubmed/1505031 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21276098 http://www.ncbi.nlm.nih.gov/pubmed/21276098 PubMed 2832401 http://www.ncbi.nlm.nih.gov/pubmed/2832401 PubMed 8805534 http://www.ncbi.nlm.nih.gov/pubmed/8805534 PubMed 8808925 http://www.ncbi.nlm.nih.gov/pubmed/8808925 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 8910376 http://www.ncbi.nlm.nih.gov/pubmed/8910376 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_415474 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415474 RefSeq WP_000227927 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000227927 SMR P0A6Q3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6Q3 STRING 511145.b0954 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0954&targetmode=cogs STRING COG0764 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0764&targetmode=cogs SUPFAM SSF54637 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54637 TIGRFAMs TIGR01749 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01749 UniProtKB FABA_ECOLI http://www.uniprot.org/uniprot/FABA_ECOLI UniProtKB-AC P0A6Q3 http://www.uniprot.org/uniprot/P0A6Q3 charge swissprot:FABA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FABA_ECOLI eggNOG COG0764 http://eggnogapi.embl.de/nog_data/html/tree/COG0764 eggNOG ENOG4108RKI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108RKI epestfind swissprot:FABA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FABA_ECOLI garnier swissprot:FABA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FABA_ECOLI helixturnhelix swissprot:FABA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FABA_ECOLI hmoment swissprot:FABA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FABA_ECOLI iep swissprot:FABA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FABA_ECOLI inforesidue swissprot:FABA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FABA_ECOLI octanol swissprot:FABA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FABA_ECOLI pepcoil swissprot:FABA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FABA_ECOLI pepdigest swissprot:FABA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FABA_ECOLI pepinfo swissprot:FABA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FABA_ECOLI pepnet swissprot:FABA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FABA_ECOLI pepstats swissprot:FABA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FABA_ECOLI pepwheel swissprot:FABA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FABA_ECOLI pepwindow swissprot:FABA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FABA_ECOLI sigcleave swissprot:FABA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FABA_ECOLI ## Database ID URL or Descriptions # AltName METJ_ECOLI Met regulon regulatory protein MetJ # BioGrid 4263206 4 # CDD cd00490 Met_repressor_MetJ # DOMAIN METJ_ECOLI Does not bind DNA by a helix-turn-helix motif. # EcoGene EG10588 metJ # FUNCTION METJ_ECOLI This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis. It is also autoregulated. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0009086 methionine biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.140.10 -; 1. # HAMAP MF_00744 MetJ # InterPro IPR002084 Met_repressor_MetJ # InterPro IPR010985 Ribbon_hlx_hlx # InterPro IPR023453 Met_repressor_MetJ_dom # KEGG_Brite ko03000 Transcription factors # Organism METJ_ECOLI Escherichia coli (strain K12) # PATRIC 32123395 VBIEscCol129921_4058 # PDB 1CMA X-ray; 2.80 A; A/B=2-105 # PDB 1CMB X-ray; 1.80 A; A/B=2-105 # PDB 1CMC X-ray; 1.80 A; A/B=2-105 # PDB 1MJ2 X-ray; 2.40 A; A/B/C/D=2-105 # PDB 1MJK X-ray; 2.15 A; A/B=2-105 # PDB 1MJL X-ray; 2.10 A; A/B=2-105 # PDB 1MJM X-ray; 2.20 A; A/B=2-105 # PDB 1MJO X-ray; 2.10 A; A/B/C/D=2-105 # PDB 1MJP X-ray; 3.40 A; A/B=2-105 # PDB 1MJQ X-ray; 2.40 A; A/B/C/D/G/H/I/J=2-105 # PIR A22660 RGECMJ # Pfam PF01340 MetJ # ProDom PD020365 Met_repressor_MetJ # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName METJ_ECOLI Met repressor # RefSeq NP_418373 NC_000913.3 # RefSeq WP_000852812 NZ_LN832404.1 # SIMILARITY Belongs to the MetJ family. {ECO 0000305}. # SUBCELLULAR LOCATION METJ_ECOLI Cytoplasm. # SUBUNIT METJ_ECOLI Homodimer. # SUPFAM SSF47598 SSF47598 # eggNOG COG3060 LUCA BLAST swissprot:METJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:METJ_ECOLI BioCyc ECOL316407:JW3909-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3909-MONOMER BioCyc EcoCyc:PD04032 http://biocyc.org/getid?id=EcoCyc:PD04032 COG COG3060 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3060 DIP DIP-47929N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47929N DOI 10.1038/341705a0 http://dx.doi.org/10.1038/341705a0 DOI 10.1038/359387a0 http://dx.doi.org/10.1038/359387a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL M12869 http://www.ebi.ac.uk/ena/data/view/M12869 EMBL M38202 http://www.ebi.ac.uk/ena/data/view/M38202 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0583 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0583 EcoGene EG10588 http://www.ecogene.org/geneInfo.php?eg_id=EG10588 EnsemblBacteria AAC76920 http://www.ensemblgenomes.org/id/AAC76920 EnsemblBacteria AAC76920 http://www.ensemblgenomes.org/id/AAC76920 EnsemblBacteria BAE77372 http://www.ensemblgenomes.org/id/BAE77372 EnsemblBacteria BAE77372 http://www.ensemblgenomes.org/id/BAE77372 EnsemblBacteria BAE77372 http://www.ensemblgenomes.org/id/BAE77372 EnsemblBacteria b3938 http://www.ensemblgenomes.org/id/b3938 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0009086 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009086 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.140.10 http://www.cathdb.info/version/latest/superfamily/1.10.140.10 GeneID 948435 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948435 HAMAP MF_00744 http://hamap.expasy.org/unirule/MF_00744 HOGENOM HOG000271582 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000271582&db=HOGENOM6 IntAct P0A8U6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8U6* InterPro IPR002084 http://www.ebi.ac.uk/interpro/entry/IPR002084 InterPro IPR010985 http://www.ebi.ac.uk/interpro/entry/IPR010985 InterPro IPR023453 http://www.ebi.ac.uk/interpro/entry/IPR023453 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW3909 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3909 KEGG_Gene eco:b3938 http://www.genome.jp/dbget-bin/www_bget?eco:b3938 KEGG_Orthology KO:K03764 http://www.genome.jp/dbget-bin/www_bget?KO:K03764 MINT MINT-1265451 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1265451 OMA WNGQYIS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WNGQYIS PDB 1CMA http://www.ebi.ac.uk/pdbe-srv/view/entry/1CMA PDB 1CMB http://www.ebi.ac.uk/pdbe-srv/view/entry/1CMB PDB 1CMC http://www.ebi.ac.uk/pdbe-srv/view/entry/1CMC PDB 1MJ2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1MJ2 PDB 1MJK http://www.ebi.ac.uk/pdbe-srv/view/entry/1MJK PDB 1MJL http://www.ebi.ac.uk/pdbe-srv/view/entry/1MJL PDB 1MJM http://www.ebi.ac.uk/pdbe-srv/view/entry/1MJM PDB 1MJO http://www.ebi.ac.uk/pdbe-srv/view/entry/1MJO PDB 1MJP http://www.ebi.ac.uk/pdbe-srv/view/entry/1MJP PDB 1MJQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1MJQ PDBsum 1CMA http://www.ebi.ac.uk/pdbsum/1CMA PDBsum 1CMB http://www.ebi.ac.uk/pdbsum/1CMB PDBsum 1CMC http://www.ebi.ac.uk/pdbsum/1CMC PDBsum 1MJ2 http://www.ebi.ac.uk/pdbsum/1MJ2 PDBsum 1MJK http://www.ebi.ac.uk/pdbsum/1MJK PDBsum 1MJL http://www.ebi.ac.uk/pdbsum/1MJL PDBsum 1MJM http://www.ebi.ac.uk/pdbsum/1MJM PDBsum 1MJO http://www.ebi.ac.uk/pdbsum/1MJO PDBsum 1MJP http://www.ebi.ac.uk/pdbsum/1MJP PDBsum 1MJQ http://www.ebi.ac.uk/pdbsum/1MJQ PSORT swissprot:METJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:METJ_ECOLI PSORT-B swissprot:METJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:METJ_ECOLI PSORT2 swissprot:METJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:METJ_ECOLI Pfam PF01340 http://pfam.xfam.org/family/PF01340 Phobius swissprot:METJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:METJ_ECOLI ProteinModelPortal P0A8U6 http://www.proteinmodelportal.org/query/uniprot/P0A8U6 PubMed 1406951 http://www.ncbi.nlm.nih.gov/pubmed/1406951 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2141834 http://www.ncbi.nlm.nih.gov/pubmed/2141834 PubMed 2677753 http://www.ncbi.nlm.nih.gov/pubmed/2677753 PubMed 6094549 http://www.ncbi.nlm.nih.gov/pubmed/6094549 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418373 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418373 RefSeq WP_000852812 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000852812 SMR P0A8U6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8U6 STRING 511145.b3938 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3938&targetmode=cogs STRING COG3060 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3060&targetmode=cogs SUPFAM SSF47598 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47598 UniProtKB METJ_ECOLI http://www.uniprot.org/uniprot/METJ_ECOLI UniProtKB-AC P0A8U6 http://www.uniprot.org/uniprot/P0A8U6 charge swissprot:METJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:METJ_ECOLI eggNOG COG3060 http://eggnogapi.embl.de/nog_data/html/tree/COG3060 epestfind swissprot:METJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:METJ_ECOLI garnier swissprot:METJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:METJ_ECOLI helixturnhelix swissprot:METJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:METJ_ECOLI hmoment swissprot:METJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:METJ_ECOLI iep swissprot:METJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:METJ_ECOLI inforesidue swissprot:METJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:METJ_ECOLI octanol swissprot:METJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:METJ_ECOLI pepcoil swissprot:METJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:METJ_ECOLI pepdigest swissprot:METJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:METJ_ECOLI pepinfo swissprot:METJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:METJ_ECOLI pepnet swissprot:METJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:METJ_ECOLI pepstats swissprot:METJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:METJ_ECOLI pepwheel swissprot:METJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:METJ_ECOLI pepwindow swissprot:METJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:METJ_ECOLI sigcleave swissprot:METJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:METJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4261925 14 # EcoGene EG12119 ychJ # Gene3D 3.10.450.50 -; 1. # HAMAP MF_00612 UPF0225 # IntAct P37052 27 # InterPro IPR004027 SEC_C_motif # InterPro IPR023006 UPF0225 # InterPro IPR032710 NTF2-like_dom # Organism YCHJ_ECOLI Escherichia coli (strain K12) # PATRIC 32117722 VBIEscCol129921_1281 # PIR D64870 D64870 # Pfam PF02810 SEC-C; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCHJ_ECOLI UPF0225 protein YchJ # RefSeq NP_415749 NC_000913.3 # RefSeq WP_001307143 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0225 family. {ECO 0000305}. # SUPFAM SSF54427 SSF54427 # eggNOG COG3012 LUCA # eggNOG ENOG4105K5B Bacteria BLAST swissprot:YCHJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCHJ_ECOLI BioCyc ECOL316407:JW1221-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1221-MONOMER BioCyc EcoCyc:EG12119-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12119-MONOMER COG COG3012 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3012 DIP DIP-11572N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11572N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L20251 http://www.ebi.ac.uk/ena/data/view/L20251 EMBL M64675 http://www.ebi.ac.uk/ena/data/view/M64675 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2040 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2040 EcoGene EG12119 http://www.ecogene.org/geneInfo.php?eg_id=EG12119 EnsemblBacteria AAC74315 http://www.ensemblgenomes.org/id/AAC74315 EnsemblBacteria AAC74315 http://www.ensemblgenomes.org/id/AAC74315 EnsemblBacteria BAA36101 http://www.ensemblgenomes.org/id/BAA36101 EnsemblBacteria BAA36101 http://www.ensemblgenomes.org/id/BAA36101 EnsemblBacteria BAA36101 http://www.ensemblgenomes.org/id/BAA36101 EnsemblBacteria b1233 http://www.ensemblgenomes.org/id/b1233 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.10.450.50 http://www.cathdb.info/version/latest/superfamily/3.10.450.50 GeneID 945828 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945828 HAMAP MF_00612 http://hamap.expasy.org/unirule/MF_00612 HOGENOM HOG000252587 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000252587&db=HOGENOM6 InParanoid P37052 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37052 IntAct P37052 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37052* InterPro IPR004027 http://www.ebi.ac.uk/interpro/entry/IPR004027 InterPro IPR023006 http://www.ebi.ac.uk/interpro/entry/IPR023006 InterPro IPR032710 http://www.ebi.ac.uk/interpro/entry/IPR032710 KEGG_Gene ecj:JW1221 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1221 KEGG_Gene eco:b1233 http://www.genome.jp/dbget-bin/www_bget?eco:b1233 KEGG_Orthology KO:K09858 http://www.genome.jp/dbget-bin/www_bget?KO:K09858 MINT MINT-1254950 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1254950 OMA CCGHYHA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CCGHYHA PSORT swissprot:YCHJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCHJ_ECOLI PSORT-B swissprot:YCHJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCHJ_ECOLI PSORT2 swissprot:YCHJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCHJ_ECOLI Pfam PF02810 http://pfam.xfam.org/family/PF02810 Phobius swissprot:YCHJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCHJ_ECOLI PhylomeDB P37052 http://phylomedb.org/?seqid=P37052 ProteinModelPortal P37052 http://www.proteinmodelportal.org/query/uniprot/P37052 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8226647 http://www.ncbi.nlm.nih.gov/pubmed/8226647 PubMed 8282700 http://www.ncbi.nlm.nih.gov/pubmed/8282700 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415749 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415749 RefSeq WP_001307143 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001307143 SMR P37052 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37052 STRING 511145.b1233 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1233&targetmode=cogs STRING COG3012 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3012&targetmode=cogs SUPFAM SSF54427 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54427 UniProtKB YCHJ_ECOLI http://www.uniprot.org/uniprot/YCHJ_ECOLI UniProtKB-AC P37052 http://www.uniprot.org/uniprot/P37052 charge swissprot:YCHJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCHJ_ECOLI eggNOG COG3012 http://eggnogapi.embl.de/nog_data/html/tree/COG3012 eggNOG ENOG4105K5B http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K5B epestfind swissprot:YCHJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCHJ_ECOLI garnier swissprot:YCHJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCHJ_ECOLI helixturnhelix swissprot:YCHJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCHJ_ECOLI hmoment swissprot:YCHJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCHJ_ECOLI iep swissprot:YCHJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCHJ_ECOLI inforesidue swissprot:YCHJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCHJ_ECOLI octanol swissprot:YCHJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCHJ_ECOLI pepcoil swissprot:YCHJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCHJ_ECOLI pepdigest swissprot:YCHJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCHJ_ECOLI pepinfo swissprot:YCHJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCHJ_ECOLI pepnet swissprot:YCHJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCHJ_ECOLI pepstats swissprot:YCHJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCHJ_ECOLI pepwheel swissprot:YCHJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCHJ_ECOLI pepwindow swissprot:YCHJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCHJ_ECOLI sigcleave swissprot:YCHJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCHJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4262864 21 # CDD cd01948 EAL # COFACTOR BLUF_ECOLI Name=FAD; Xref=ChEBI CHEBI 57692; Evidence={ECO 0000269|PubMed 15453820}; Note=Binds 1 FAD per subunit, non-covalently bound to the BLUF domain. {ECO 0000269|PubMed 15453820}; # DISRUPTION PHENOTYPE Reduces expression of ycgZ in the presence but not the absence of BluR. At 16 degrees Celsius, reduces expression of genes (including ycgZ) for several small proteins. While the BluR/F system is induced at low temperatures under blue light irradiation, it is not essential for growth under these conditions. {ECO:0000269|PubMed 19240136}. # DOMAIN BLUF_ECOLI Contains a defective C-terminal cyclic-di-GMP phosphodiesterase EAL domain, which lacks key amino acids required for phosphodiesterase activity. Restoration of consensus amino acids in the degenerate EAL domain does not restore phosphodiesterase activity and reduces ability to antagonize BluR. {ECO 0000269|PubMed 22783906}. # DOMAIN BLUF_ECOLI The joining helix is required for stability of the light- adapted state. {ECO 0000269|PubMed 18792053}. # EcoGene EG13887 bluF # FUNCTION BLUF_ECOLI Binds to and releases the BluR repressor from its bound DNA target in a blue light-dependent (470 nm) fashion. A shift to low temperature also triggers a BluF-mediated relief of repression by BluR, suggesting BluF may serve as a thermometer. Blue light may act to increase the affinity of BluF for BluR, allowing it to be released from its operator. The protein has a reversible photocycle, and undergoes structural changes, probably in the EAL domain, in response to light. {ECO 0000269|PubMed 15453820, ECO 0000269|PubMed 19240136, ECO 0000269|PubMed 20141167, ECO 0000269|PubMed 22783906}. # GO_function GO:0009882 blue light photoreceptor activity; IEA:InterPro. # GO_function GO:0050660 flavin adenine dinucleotide binding; IDA:EcoCyc. # GO_function GO:0070491 repressing transcription factor binding; IPI:EcoCyc. # GO_function GO:0071949 FAD binding; IEA:InterPro. # GO_process GO:0009637 response to blue light; IDA:EcoCyc. # GO_process GO:0018298 protein-chromophore linkage; IEA:UniProtKB-KW. # GO_process GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity; IDA:EcoCyc. # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0008134 transcription factor binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0008150 biological_process # Gene3D 3.20.20.450 -; 1. # INDUCTION BLUF_ECOLI Expression is strongly activated by cold shock (over 30-fold at 16 degrees Celsius compared to 37 degrees) at low temperature in a PNPase-dependent fashion. Repressed by RpoS. {ECO 0000269|PubMed 14527658, ECO 0000269|PubMed 19332833}. # IntAct P75990 13 # InterPro IPR001633 EAL_dom # InterPro IPR001792 Acylphosphatase-like_dom # InterPro IPR007024 BLUF_domain # Organism BLUF_ECOLI Escherichia coli (strain K12) # PATRIC 32117563 VBIEscCol129921_1204 # PIR H64861 H64861 # PROSITE PS50883 EAL # PROSITE PS50925 BLUF # Pfam PF00563 EAL # Pfam PF04940 BLUF # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BLUF_ECOLI Blue light- and temperature-regulated antirepressor BluF # RefSeq NP_415681 NC_000913.3 # RefSeq WP_001299269 NZ_LN832404.1 # SIMILARITY Contains 1 BLUF domain. {ECO:0000255|PROSITE- ProRule PRU00030}. # SIMILARITY Contains 1 EAL domain. {ECO:0000255|PROSITE- ProRule PRU00074}. # SMART SM00052 EAL # SMART SM01034 BLUF # SUBUNIT BLUF_ECOLI Monomer, it undergoes transient dimerization following photoexcitation or upon temperature reduction, with a relaxation time of about 2 minutes. The dimer may be the inactive state. Interacts with the N- and C-terminal domains of BluR. Can also interact with the C-terminal domain of MlrA. {ECO 0000269|PubMed 15453820, ECO 0000269|PubMed 17489591, ECO 0000269|PubMed 19240136, ECO 0000269|PubMed 20141167, ECO 0000269|PubMed 22783906}. # SUPFAM SSF141868 SSF141868 # SUPFAM SSF54975 SSF54975 # eggNOG ENOG4105BZU Bacteria # eggNOG ENOG410XNMH LUCA BLAST swissprot:BLUF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BLUF_ECOLI BioCyc ECOL316407:JW1150-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1150-MONOMER BioCyc EcoCyc:G6603-MONOMER http://biocyc.org/getid?id=EcoCyc:G6603-MONOMER DIP DIP-11553N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11553N DOI 10.1002/cbic.200800280 http://dx.doi.org/10.1002/cbic.200800280 DOI 10.1016/S0923-2508(03)00167-0 http://dx.doi.org/10.1016/S0923-2508(03)00167-0 DOI 10.1021/bi051820x http://dx.doi.org/10.1021/bi051820x DOI 10.1021/bi902121z http://dx.doi.org/10.1021/bi902121z DOI 10.1021/ja065682q http://dx.doi.org/10.1021/ja065682q DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1099/mic.0.024257-0 http://dx.doi.org/10.1099/mic.0.024257-0 DOI 10.1101/gad.499409 http://dx.doi.org/10.1101/gad.499409 DOI 10.1111/j.1365-2958.2012.08147.x http://dx.doi.org/10.1111/j.1365-2958.2012.08147.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1562/0031-8655(2004)080<0542:PAICOA>2.0.CO http://dx.doi.org/10.1562/0031-8655(2004)080<0542:PAICOA>2.0.CO EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3646 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3646 EcoGene EG13887 http://www.ecogene.org/geneInfo.php?eg_id=EG13887 EnsemblBacteria AAC74247 http://www.ensemblgenomes.org/id/AAC74247 EnsemblBacteria AAC74247 http://www.ensemblgenomes.org/id/AAC74247 EnsemblBacteria BAA35998 http://www.ensemblgenomes.org/id/BAA35998 EnsemblBacteria BAA35998 http://www.ensemblgenomes.org/id/BAA35998 EnsemblBacteria BAA35998 http://www.ensemblgenomes.org/id/BAA35998 EnsemblBacteria b1163 http://www.ensemblgenomes.org/id/b1163 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0009882 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009882 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_function GO:0070491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070491 GO_function GO:0071949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071949 GO_process GO:0009637 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009637 GO_process GO:0018298 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018298 GO_process GO:0043433 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043433 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0008134 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008134 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.20.20.450 http://www.cathdb.info/version/latest/superfamily/3.20.20.450 GeneID 947592 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947592 HOGENOM HOG000119657 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000119657&db=HOGENOM6 InParanoid P75990 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75990 IntAct P75990 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75990* InterPro IPR001633 http://www.ebi.ac.uk/interpro/entry/IPR001633 InterPro IPR001792 http://www.ebi.ac.uk/interpro/entry/IPR001792 InterPro IPR007024 http://www.ebi.ac.uk/interpro/entry/IPR007024 KEGG_Gene ecj:JW1150 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1150 KEGG_Gene eco:b1163 http://www.genome.jp/dbget-bin/www_bget?eco:b1163 OMA GISQFQG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GISQFQG PROSITE PS50883 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50883 PROSITE PS50925 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50925 PSORT swissprot:BLUF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BLUF_ECOLI PSORT-B swissprot:BLUF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BLUF_ECOLI PSORT2 swissprot:BLUF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BLUF_ECOLI Pfam PF00563 http://pfam.xfam.org/family/PF00563 Pfam PF04940 http://pfam.xfam.org/family/PF04940 Phobius swissprot:BLUF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BLUF_ECOLI PhylomeDB P75990 http://phylomedb.org/?seqid=P75990 ProteinModelPortal P75990 http://www.proteinmodelportal.org/query/uniprot/P75990 PubMed 14527658 http://www.ncbi.nlm.nih.gov/pubmed/14527658 PubMed 15453820 http://www.ncbi.nlm.nih.gov/pubmed/15453820 PubMed 16533062 http://www.ncbi.nlm.nih.gov/pubmed/16533062 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17489591 http://www.ncbi.nlm.nih.gov/pubmed/17489591 PubMed 18792053 http://www.ncbi.nlm.nih.gov/pubmed/18792053 PubMed 19240136 http://www.ncbi.nlm.nih.gov/pubmed/19240136 PubMed 19332833 http://www.ncbi.nlm.nih.gov/pubmed/19332833 PubMed 20141167 http://www.ncbi.nlm.nih.gov/pubmed/20141167 PubMed 22783906 http://www.ncbi.nlm.nih.gov/pubmed/22783906 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415681 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415681 RefSeq WP_001299269 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001299269 SMART SM00052 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00052 SMART SM01034 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01034 SMR P75990 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75990 STRING 511145.b1163 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1163&targetmode=cogs SUPFAM SSF141868 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF141868 SUPFAM SSF54975 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54975 UniProtKB BLUF_ECOLI http://www.uniprot.org/uniprot/BLUF_ECOLI UniProtKB-AC P75990 http://www.uniprot.org/uniprot/P75990 charge swissprot:BLUF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BLUF_ECOLI eggNOG ENOG4105BZU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZU eggNOG ENOG410XNMH http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNMH epestfind swissprot:BLUF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BLUF_ECOLI garnier swissprot:BLUF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BLUF_ECOLI helixturnhelix swissprot:BLUF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BLUF_ECOLI hmoment swissprot:BLUF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BLUF_ECOLI iep swissprot:BLUF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BLUF_ECOLI inforesidue swissprot:BLUF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BLUF_ECOLI octanol swissprot:BLUF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BLUF_ECOLI pepcoil swissprot:BLUF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BLUF_ECOLI pepdigest swissprot:BLUF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BLUF_ECOLI pepinfo swissprot:BLUF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BLUF_ECOLI pepnet swissprot:BLUF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BLUF_ECOLI pepstats swissprot:BLUF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BLUF_ECOLI pepwheel swissprot:BLUF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BLUF_ECOLI pepwindow swissprot:BLUF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BLUF_ECOLI sigcleave swissprot:BLUF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BLUF_ECOLI ## Database ID URL or Descriptions # AltName Putative quinone oxidoreductase KefG {ECO:0000255|HAMAP-Rule MF_01415} # BioGrid 4263025 11 # CATALYTIC ACTIVITY NAD(P)H + a quinone = NAD(P)(+) + a hydroquinone. {ECO:0000255|HAMAP-Rule MF_01415}. # EcoGene EG12902 kefG # FUNCTION KEFG_ECOLI Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefB. {ECO 0000255|HAMAP-Rule MF_01415, ECO 0000269|PubMed 11053405}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_function GO:0003955 NAD(P)H dehydrogenase (quinone) activity; IEA:UniProtKB-HAMAP. # GO_process GO:0006813 potassium ion transport; IEA:InterPro. # GO_process GO:0032414 positive regulation of ion transmembrane transporter activity; IEA:UniProtKB-HAMAP. # GO_process GO:1901381 positive regulation of potassium ion transmembrane transport; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.360 -; 1. # HAMAP MF_01415 K_H_efflux_KefG # IntAct P0A756 6 # InterPro IPR003680 Flavodoxin_fold # InterPro IPR023947 K_H_efflux_KefG # InterPro IPR029039 Flavoprotein-like_dom # Organism KEFG_ECOLI Escherichia coli (strain K12) # PATRIC 32122136 VBIEscCol129921_3445 # PIR B65129 B65129 # Pfam PF02525 Flavodoxin_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Glutathione-regulated potassium-efflux system ancillary protein KefG {ECO:0000255|HAMAP-Rule MF_01415} # RefSeq NP_417810 NC_000913.3 # SIMILARITY Belongs to the NAD(P)H dehydrogenase (quinone) family. KefG subfamily. {ECO:0000255|HAMAP-Rule MF_01415}. # SUBCELLULAR LOCATION KEFG_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01415}; Peripheral membrane protein {ECO 0000255|HAMAP- Rule MF_01415}; Cytoplasmic side {ECO 0000255|HAMAP- Rule MF_01415}. # SUBUNIT Interacts with KefB. {ECO:0000255|HAMAP-Rule MF_01415}. # SUPFAM SSF52218 SSF52218 # TCDB 2.A.37.1:the monovalent cation proton antiporter-2 (cpa2) family # eggNOG COG2249 LUCA # eggNOG ENOG4108K2R Bacteria BLAST swissprot:KEFG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:KEFG_ECOLI BioCyc ECOL316407:JW3314-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3314-MONOMER BioCyc EcoCyc:G7717-MONOMER http://biocyc.org/getid?id=EcoCyc:G7717-MONOMER COG COG2249 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2249 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.22.6536-6540.2000 http://dx.doi.org/10.1128/JB.182.22.6536-6540.2000 EC_number EC:1.6.5.2 {ECO:0000255|HAMAP-Rule:MF_01415} http://www.genome.jp/dbget-bin/www_bget?EC:1.6.5.2 {ECO:0000255|HAMAP-Rule:MF_01415} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 1.6.5.2 {ECO:0000255|HAMAP-Rule:MF_01415} http://enzyme.expasy.org/EC/1.6.5.2 {ECO:0000255|HAMAP-Rule:MF_01415} EchoBASE EB2739 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2739 EcoGene EG12902 http://www.ecogene.org/geneInfo.php?eg_id=EG12902 EnsemblBacteria AAC76376 http://www.ensemblgenomes.org/id/AAC76376 EnsemblBacteria AAC76376 http://www.ensemblgenomes.org/id/AAC76376 EnsemblBacteria BAE77939 http://www.ensemblgenomes.org/id/BAE77939 EnsemblBacteria BAE77939 http://www.ensemblgenomes.org/id/BAE77939 EnsemblBacteria BAE77939 http://www.ensemblgenomes.org/id/BAE77939 EnsemblBacteria b3351 http://www.ensemblgenomes.org/id/b3351 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0003955 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003955 GO_process GO:0006813 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006813 GO_process GO:0032414 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032414 GO_process GO:1901381 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901381 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.360 http://www.cathdb.info/version/latest/superfamily/3.40.50.360 GeneID 947857 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947857 HAMAP MF_01415 http://hamap.expasy.org/unirule/MF_01415 HOGENOM HOG000149972 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000149972&db=HOGENOM6 InParanoid P0A756 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A756 IntAct P0A756 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A756* IntEnz 1.6.5.2 {ECO:0000255|HAMAP-Rule:MF_01415} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.6.5.2 {ECO:0000255|HAMAP-Rule:MF_01415} InterPro IPR003680 http://www.ebi.ac.uk/interpro/entry/IPR003680 InterPro IPR023947 http://www.ebi.ac.uk/interpro/entry/IPR023947 InterPro IPR029039 http://www.ebi.ac.uk/interpro/entry/IPR029039 KEGG_Gene ecj:JW3314 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3314 KEGG_Gene eco:b3351 http://www.genome.jp/dbget-bin/www_bget?eco:b3351 KEGG_Orthology KO:K11748 http://www.genome.jp/dbget-bin/www_bget?KO:K11748 OMA RYPMSDI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RYPMSDI PSORT swissprot:KEFG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:KEFG_ECOLI PSORT-B swissprot:KEFG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:KEFG_ECOLI PSORT2 swissprot:KEFG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:KEFG_ECOLI Pfam PF02525 http://pfam.xfam.org/family/PF02525 Phobius swissprot:KEFG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:KEFG_ECOLI PhylomeDB P0A756 http://phylomedb.org/?seqid=P0A756 ProteinModelPortal P0A756 http://www.proteinmodelportal.org/query/uniprot/P0A756 PubMed 11053405 http://www.ncbi.nlm.nih.gov/pubmed/11053405 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417810 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417810 SMR P0A756 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A756 STRING 511145.b3351 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3351&targetmode=cogs STRING COG2249 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2249&targetmode=cogs SUPFAM SSF52218 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52218 TCDB 2.A.37.1 http://www.tcdb.org/search/result.php?tc=2.A.37.1 UniProtKB KEFG_ECOLI http://www.uniprot.org/uniprot/KEFG_ECOLI UniProtKB-AC P0A756 http://www.uniprot.org/uniprot/P0A756 charge swissprot:KEFG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:KEFG_ECOLI eggNOG COG2249 http://eggnogapi.embl.de/nog_data/html/tree/COG2249 eggNOG ENOG4108K2R http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108K2R epestfind swissprot:KEFG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:KEFG_ECOLI garnier swissprot:KEFG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:KEFG_ECOLI helixturnhelix swissprot:KEFG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:KEFG_ECOLI hmoment swissprot:KEFG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:KEFG_ECOLI iep swissprot:KEFG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:KEFG_ECOLI inforesidue swissprot:KEFG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:KEFG_ECOLI octanol swissprot:KEFG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:KEFG_ECOLI pepcoil swissprot:KEFG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:KEFG_ECOLI pepdigest swissprot:KEFG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:KEFG_ECOLI pepinfo swissprot:KEFG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:KEFG_ECOLI pepnet swissprot:KEFG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:KEFG_ECOLI pepstats swissprot:KEFG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:KEFG_ECOLI pepwheel swissprot:KEFG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:KEFG_ECOLI pepwindow swissprot:KEFG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:KEFG_ECOLI sigcleave swissprot:KEFG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:KEFG_ECOLI ## Database ID URL or Descriptions # AltName ALLC_ECOLI Allantoate deiminase # BRENDA 3.5.3 2026 # BioGrid 4261167 17 # CDD cd03884 M20_bAS # COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI 29105; Note=Binds 2 Zn(2+) ions per subunit.; # EcoGene EG13623 allC # FUNCTION ALLC_ECOLI Involved in the anaerobic utilization of allantoin. Converts allantoate to (S)-ureidoglycolate and ammonia. {ECO 0000269|PubMed 10601204}. # GO_function GO:0030145 manganese ion binding; IDA:EcoCyc. # GO_function GO:0047652 allantoate deiminase activity; IDA:EcoCyc. # GO_process GO:0006144 purine nucleobase metabolic process; IEA:UniProtKB-KW. # GO_process GO:0009442 allantoin assimilation pathway; IDA:EcoCyc. # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.30.70.360 -; 1. # INDUCTION ALLC_ECOLI By glyoxylate and allantoin under anaerobic conditions. # IntAct P77425 9 # InterPro IPR002933 Peptidase_M20 # InterPro IPR010158 Amidase_Cbmase # InterPro IPR011650 Peptidase_M20_dimer # InterPro IPR017591 Allantoate_amidohydrolase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # KEGG_Pathway ko00230 Purine metabolism # Organism ALLC_ECOLI Escherichia coli (strain K12) # PATHWAY ALLC_ECOLI Nitrogen metabolism; (S)-allantoin degradation. # PATRIC 32116189 VBIEscCol129921_0536 # PDB 1Z2L X-ray; 2.25 A; A/B=2-411 # PDB 2IMO X-ray; 2.80 A; A/B=2-411 # PDB 4PXD X-ray; 2.20 A; A/B=1-411 # PIR C64783 C64783 # PIRSF PIRSF001235 Amidase_carbamoylase # Pfam PF01546 Peptidase_M20 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ALLC_ECOLI Allantoate amidohydrolase # RefSeq NP_415049 NC_000913.3 # RefSeq WP_001310618 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase M20 family. {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 17362992}. # SUPFAM SSF55031 SSF55031 # TIGRFAMs TIGR01879 hydantase # TIGRFAMs TIGR03176 AllC # eggNOG COG0624 LUCA # eggNOG ENOG4105CE7 Bacteria BLAST swissprot:ALLC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ALLC_ECOLI BioCyc ECOL316407:JW0504-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0504-MONOMER BioCyc EcoCyc:G6285-MONOMER http://biocyc.org/getid?id=EcoCyc:G6285-MONOMER BioCyc MetaCyc:G6285-MONOMER http://biocyc.org/getid?id=MetaCyc:G6285-MONOMER COG COG0624 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0624 DIP DIP-9088N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9088N DOI 10.1016/j.jmb.2007.02.028 http://dx.doi.org/10.1016/j.jmb.2007.02.028 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.5.3.- http://www.genome.jp/dbget-bin/www_bget?EC:3.5.3.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL U89279 http://www.ebi.ac.uk/ena/data/view/U89279 ENZYME 3.5.3.- http://enzyme.expasy.org/EC/3.5.3.- EchoBASE EB3388 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3388 EcoGene EG13623 http://www.ecogene.org/geneInfo.php?eg_id=EG13623 EnsemblBacteria AAC73618 http://www.ensemblgenomes.org/id/AAC73618 EnsemblBacteria AAC73618 http://www.ensemblgenomes.org/id/AAC73618 EnsemblBacteria BAE76294 http://www.ensemblgenomes.org/id/BAE76294 EnsemblBacteria BAE76294 http://www.ensemblgenomes.org/id/BAE76294 EnsemblBacteria BAE76294 http://www.ensemblgenomes.org/id/BAE76294 EnsemblBacteria b0516 http://www.ensemblgenomes.org/id/b0516 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_function GO:0047652 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047652 GO_process GO:0006144 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006144 GO_process GO:0009442 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009442 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.30.70.360 http://www.cathdb.info/version/latest/superfamily/3.30.70.360 GeneID 945150 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945150 HOGENOM HOG000241291 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000241291&db=HOGENOM6 InParanoid P77425 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77425 IntAct P77425 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77425* IntEnz 3.5.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.3 InterPro IPR002933 http://www.ebi.ac.uk/interpro/entry/IPR002933 InterPro IPR010158 http://www.ebi.ac.uk/interpro/entry/IPR010158 InterPro IPR011650 http://www.ebi.ac.uk/interpro/entry/IPR011650 InterPro IPR017591 http://www.ebi.ac.uk/interpro/entry/IPR017591 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW0504 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0504 KEGG_Gene eco:b0516 http://www.genome.jp/dbget-bin/www_bget?eco:b0516 KEGG_Orthology KO:K02083 http://www.genome.jp/dbget-bin/www_bget?KO:K02083 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Reaction rn:R02423 http://www.genome.jp/dbget-bin/www_bget?rn:R02423 OMA IVNFGDE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IVNFGDE PDB 1Z2L http://www.ebi.ac.uk/pdbe-srv/view/entry/1Z2L PDB 2IMO http://www.ebi.ac.uk/pdbe-srv/view/entry/2IMO PDB 4PXD http://www.ebi.ac.uk/pdbe-srv/view/entry/4PXD PDBsum 1Z2L http://www.ebi.ac.uk/pdbsum/1Z2L PDBsum 2IMO http://www.ebi.ac.uk/pdbsum/2IMO PDBsum 4PXD http://www.ebi.ac.uk/pdbsum/4PXD PSORT swissprot:ALLC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ALLC_ECOLI PSORT-B swissprot:ALLC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ALLC_ECOLI PSORT2 swissprot:ALLC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ALLC_ECOLI Pfam PF01546 http://pfam.xfam.org/family/PF01546 Phobius swissprot:ALLC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ALLC_ECOLI PhylomeDB P77425 http://phylomedb.org/?seqid=P77425 ProteinModelPortal P77425 http://www.proteinmodelportal.org/query/uniprot/P77425 PubMed 10601204 http://www.ncbi.nlm.nih.gov/pubmed/10601204 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17362992 http://www.ncbi.nlm.nih.gov/pubmed/17362992 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415049 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415049 RefSeq WP_001310618 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001310618 SMR P77425 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77425 STRING 511145.b0516 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0516&targetmode=cogs STRING COG0624 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0624&targetmode=cogs SUPFAM SSF55031 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55031 TIGRFAMs TIGR01879 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01879 TIGRFAMs TIGR03176 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03176 UniProtKB ALLC_ECOLI http://www.uniprot.org/uniprot/ALLC_ECOLI UniProtKB-AC P77425 http://www.uniprot.org/uniprot/P77425 charge swissprot:ALLC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ALLC_ECOLI eggNOG COG0624 http://eggnogapi.embl.de/nog_data/html/tree/COG0624 eggNOG ENOG4105CE7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CE7 epestfind swissprot:ALLC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ALLC_ECOLI garnier swissprot:ALLC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ALLC_ECOLI helixturnhelix swissprot:ALLC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ALLC_ECOLI hmoment swissprot:ALLC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ALLC_ECOLI iep swissprot:ALLC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ALLC_ECOLI inforesidue swissprot:ALLC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ALLC_ECOLI octanol swissprot:ALLC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ALLC_ECOLI pepcoil swissprot:ALLC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ALLC_ECOLI pepdigest swissprot:ALLC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ALLC_ECOLI pepinfo swissprot:ALLC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ALLC_ECOLI pepnet swissprot:ALLC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ALLC_ECOLI pepstats swissprot:ALLC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ALLC_ECOLI pepwheel swissprot:ALLC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ALLC_ECOLI pepwindow swissprot:ALLC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ALLC_ECOLI sigcleave swissprot:ALLC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ALLC_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES DAPF_ECOLI Kinetic parameters KM=0.16 mM for D,L-DAP (at pH 7.8 and at 25 degrees Celsius) {ECO 0000269|PubMed 3042781, ECO 0000269|PubMed 6378903}; KM=0.26 mM for L,L-DAP (at pH 7.8 and at 25 degrees Celsius) {ECO 0000269|PubMed 3042781, ECO 0000269|PubMed 6378903}; KM=0.36 mM for L,L-DAP (at pH 7.8 and at 25 degrees Celsius) {ECO 0000269|PubMed 3042781, ECO 0000269|PubMed 6378903}; # CATALYTIC ACTIVITY DAPF_ECOLI LL-2,6-diaminoheptanedioate = meso- diaminoheptanedioate. {ECO 0000269|PubMed 3042781, ECO 0000269|PubMed 6378903}. # ENZYME REGULATION DAPF_ECOLI Inhibited by 2-(4-amino-4-carboxybutyl)aziri- dine-2-carboxylate (aziDAP) and iodoacetamide. {ECO 0000269|PubMed 2197412, ECO 0000269|PubMed 3042781, ECO 0000269|PubMed 6378903}. # EcoGene EG10209 dapF # FUNCTION DAPF_ECOLI Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan. Only accepts DAP isomers with the L configuration. {ECO 0000269|PubMed 3031013, ECO 0000269|PubMed 3042781, ECO 0000269|PubMed 6378903}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008837 diaminopimelate epimerase activity; IDA:EcoCyc. # GO_process GO:0009089 lysine biosynthetic process via diaminopimelate; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # HAMAP MF_00197 DAP_epimerase # IntAct P0A6K1 2 # InterPro IPR001653 DAP_epimerase_DapF # InterPro IPR018510 DAP_epimerase_AS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00300 Lysine biosynthesis # Organism DAPF_ECOLI Escherichia coli (strain K12) # PANTHER PTHR31689 PTHR31689 # PATHWAY Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate step 1/1. # PATRIC 32123119 VBIEscCol129921_3925 # PDB 4IJZ X-ray; 2.00 A; A/B=1-274 # PDB 4IK0 X-ray; 2.05 A; A/B=1-274 # PIR B65185 S01913 # PROSITE PS01326 DAP_EPIMERASE # Pfam PF01678 DAP_epimerase; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DAPF_ECOLI Diaminopimelate epimerase # RefSeq NP_418254 NC_000913.3 # RefSeq WP_001160654 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA67605.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA31413.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the diaminopimelate epimerase family. {ECO 0000305}. # SUBCELLULAR LOCATION DAPF_ECOLI Cytoplasm. # SUBUNIT Monomer. {ECO:0000269|PubMed 6378903}. # TIGRFAMs TIGR00652 DapF # UniPathway UPA00034 UER00025 # eggNOG COG0253 LUCA # eggNOG ENOG4105E4Z Bacteria BLAST swissprot:DAPF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DAPF_ECOLI BioCyc ECOL316407:JW5592-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5592-MONOMER BioCyc EcoCyc:DIAMINOPIMEPIM-MONOMER http://biocyc.org/getid?id=EcoCyc:DIAMINOPIMEPIM-MONOMER BioCyc MetaCyc:DIAMINOPIMEPIM-MONOMER http://biocyc.org/getid?id=MetaCyc:DIAMINOPIMEPIM-MONOMER COG COG0253 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0253 DIP DIP-47856N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47856N DOI 10.1016/0300-9084(96)82192-4 http://dx.doi.org/10.1016/0300-9084(96)82192-4 DOI 10.1021/jm00170a018 http://dx.doi.org/10.1021/jm00170a018 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/16.21.10367 http://dx.doi.org/10.1093/nar/16.21.10367 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.1.1.7 http://www.genome.jp/dbget-bin/www_bget?EC:5.1.1.7 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M38257 http://www.ebi.ac.uk/ena/data/view/M38257 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X12968 http://www.ebi.ac.uk/ena/data/view/X12968 EMBL X66782 http://www.ebi.ac.uk/ena/data/view/X66782 ENZYME 5.1.1.7 http://enzyme.expasy.org/EC/5.1.1.7 EchoBASE EB0205 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0205 EcoGene EG10209 http://www.ecogene.org/geneInfo.php?eg_id=EG10209 EnsemblBacteria AAC76812 http://www.ensemblgenomes.org/id/AAC76812 EnsemblBacteria AAC76812 http://www.ensemblgenomes.org/id/AAC76812 EnsemblBacteria BAE77491 http://www.ensemblgenomes.org/id/BAE77491 EnsemblBacteria BAE77491 http://www.ensemblgenomes.org/id/BAE77491 EnsemblBacteria BAE77491 http://www.ensemblgenomes.org/id/BAE77491 EnsemblBacteria b3809 http://www.ensemblgenomes.org/id/b3809 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008837 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008837 GO_process GO:0009089 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009089 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 948364 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948364 HAMAP MF_00197 http://hamap.expasy.org/unirule/MF_00197 HOGENOM HOG000220466 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220466&db=HOGENOM6 InParanoid P0A6K1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6K1 IntAct P0A6K1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6K1* IntEnz 5.1.1.7 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.1.1.7 InterPro IPR001653 http://www.ebi.ac.uk/interpro/entry/IPR001653 InterPro IPR018510 http://www.ebi.ac.uk/interpro/entry/IPR018510 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5592 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5592 KEGG_Gene eco:b3809 http://www.genome.jp/dbget-bin/www_bget?eco:b3809 KEGG_Orthology KO:K01778 http://www.genome.jp/dbget-bin/www_bget?KO:K01778 KEGG_Pathway ko00300 http://www.genome.jp/kegg-bin/show_pathway?ko00300 KEGG_Reaction rn:R02735 http://www.genome.jp/dbget-bin/www_bget?rn:R02735 OMA RFTKMQG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RFTKMQG PANTHER PTHR31689 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31689 PDB 4IJZ http://www.ebi.ac.uk/pdbe-srv/view/entry/4IJZ PDB 4IK0 http://www.ebi.ac.uk/pdbe-srv/view/entry/4IK0 PDBsum 4IJZ http://www.ebi.ac.uk/pdbsum/4IJZ PDBsum 4IK0 http://www.ebi.ac.uk/pdbsum/4IK0 PROSITE PS01326 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01326 PSORT swissprot:DAPF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DAPF_ECOLI PSORT-B swissprot:DAPF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DAPF_ECOLI PSORT2 swissprot:DAPF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DAPF_ECOLI Pfam PF01678 http://pfam.xfam.org/family/PF01678 Phobius swissprot:DAPF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DAPF_ECOLI PhylomeDB P0A6K1 http://phylomedb.org/?seqid=P0A6K1 ProteinModelPortal P0A6K1 http://www.proteinmodelportal.org/query/uniprot/P0A6K1 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2197412 http://www.ncbi.nlm.nih.gov/pubmed/2197412 PubMed 2254268 http://www.ncbi.nlm.nih.gov/pubmed/2254268 PubMed 3031013 http://www.ncbi.nlm.nih.gov/pubmed/3031013 PubMed 3042781 http://www.ncbi.nlm.nih.gov/pubmed/3042781 PubMed 3057443 http://www.ncbi.nlm.nih.gov/pubmed/3057443 PubMed 6378903 http://www.ncbi.nlm.nih.gov/pubmed/6378903 PubMed 8874804 http://www.ncbi.nlm.nih.gov/pubmed/8874804 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418254 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418254 RefSeq WP_001160654 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001160654 SMR P0A6K1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6K1 STRING 511145.b3809 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3809&targetmode=cogs STRING COG0253 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0253&targetmode=cogs TIGRFAMs TIGR00652 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00652 UniProtKB DAPF_ECOLI http://www.uniprot.org/uniprot/DAPF_ECOLI UniProtKB-AC P0A6K1 http://www.uniprot.org/uniprot/P0A6K1 charge swissprot:DAPF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DAPF_ECOLI eggNOG COG0253 http://eggnogapi.embl.de/nog_data/html/tree/COG0253 eggNOG ENOG4105E4Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E4Z epestfind swissprot:DAPF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DAPF_ECOLI garnier swissprot:DAPF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DAPF_ECOLI helixturnhelix swissprot:DAPF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DAPF_ECOLI hmoment swissprot:DAPF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DAPF_ECOLI iep swissprot:DAPF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DAPF_ECOLI inforesidue swissprot:DAPF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DAPF_ECOLI octanol swissprot:DAPF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DAPF_ECOLI pepcoil swissprot:DAPF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DAPF_ECOLI pepdigest swissprot:DAPF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DAPF_ECOLI pepinfo swissprot:DAPF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DAPF_ECOLI pepnet swissprot:DAPF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DAPF_ECOLI pepstats swissprot:DAPF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DAPF_ECOLI pepwheel swissprot:DAPF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DAPF_ECOLI pepwindow swissprot:DAPF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DAPF_ECOLI sigcleave swissprot:DAPF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DAPF_ECOLI ## Database ID URL or Descriptions # AltName DNAK_ECOLI HSP70 # AltName DNAK_ECOLI Heat shock 70 kDa protein # AltName DNAK_ECOLI Heat shock protein 70 # BioGrid 4259520 125 # BioGrid 849153 8 # DISRUPTION PHENOTYPE Non-essential; synthetic lethality is seen in a triple tig-dnaK-dnaJ disruption, although this depends on temperature (triple disruptions grow slowly at 20 and 34 degrees Celsius but not at all at 43 degrees) and strain background. {ECO:0000269|PubMed 14726952}. # EcoGene EG10241 dnaK # FUNCTION DNAK_ECOLI Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock. # GO_component GO:0005737 cytoplasm; IDA:UniProtKB. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0005524 ATP binding; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IDA:EcoliWiki. # GO_function GO:0016989 sigma factor antagonist activity; IDA:EcoCyc. # GO_function GO:0043531 ADP binding; IDA:EcoCyc. # GO_function GO:0044183 protein binding involved in protein folding; IDA:EcoCyc. # GO_function GO:0051082 unfolded protein binding; IDA:EcoCyc. # GO_process GO:0006260 DNA replication; IEA:UniProtKB-KW. # GO_process GO:0006461 protein complex assembly; IDA:EcoCyc. # GO_process GO:0009408 response to heat; IDA:EcoCyc. # GO_process GO:0034620 cellular response to unfolded protein; IDA:EcoCyc. # GO_process GO:0043241 protein complex disassembly; IDA:EcoCyc. # GO_process GO:0051085 chaperone mediated protein folding requiring cofactor; IMP:EcoCyc. # GO_process GO:0070389 chaperone cofactor-dependent protein refolding; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0000988 transcription factor activity, protein binding # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_function GO:0051082 unfolded protein binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006457 protein folding # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # Gene3D 1.20.1270.10 -; 1. # Gene3D 2.60.34.10 -; 1. # HAMAP MF_00332 DnaK # INTERACTION DNAK_ECOLI P0AC38 aspA; NbExp=2; IntAct=EBI-542092, EBI-544200; P36659 cbpA; NbExp=4; IntAct=EBI-542092, EBI-546131; P08622 dnaJ; NbExp=5; IntAct=EBI-542092, EBI-545285; P0AAI5 fabF; NbExp=2; IntAct=EBI-542092, EBI-542783; P0AB71 fbaA; NbExp=2; IntAct=EBI-542092, EBI-370916; P0AC81 gloA; NbExp=2; IntAct=EBI-542092, EBI-551143; P0A6Z3 htpG; NbExp=3; IntAct=EBI-542092, EBI-369221; P21513 rne; NbExp=9; IntAct=EBI-542092, EBI-549958; P0AGB3 rpoH; NbExp=5; IntAct=EBI-542092, EBI-555342; P0ACX3 ydhR; NbExp=2; IntAct=EBI-542092, EBI-544817; Q46906 ygcP; NbExp=2; IntAct=EBI-542092, EBI-557727; # IntAct P0A6Y8 369 # InterPro IPR012725 Chaperone_DnaK # InterPro IPR013126 Hsp_70_fam # InterPro IPR018181 Heat_shock_70_CS # InterPro IPR029047 HSP70_peptide-bd # InterPro IPR029048 HSP70_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02000 Transporters # KEGG_Brite ko03110 Chaperones and folding catalysts # KEGG_Pathway ko03018 RNA degradation # KEGG_Pathway ko05152 Tuberculosis # Organism DNAK_ECOLI Escherichia coli (strain K12) # PATRIC 32115121 VBIEscCol129921_0012 # PDB 1BPR NMR; -; A=384-561 # PDB 1DG4 NMR; -; A=393-507 # PDB 1DKG X-ray; 2.80 A; D=1-383 # PDB 1DKX X-ray; 2.00 A; A=389-607 # PDB 1DKY X-ray; 2.80 A; A/B=389-607 # PDB 1DKZ X-ray; 2.00 A; A=389-607 # PDB 1Q5L NMR; -; A=393-507 # PDB 2BPR NMR; -; A=384-561 # PDB 2KHO NMR; -; A=1-605 # PDB 3DPO X-ray; 2.10 A; A/B=389-607 # PDB 3DPP X-ray; 2.50 A; A/B=389-607 # PDB 3DPQ X-ray; 2.60 A; A/B/E/F=389-601 # PDB 3QNJ X-ray; 2.28 A; A/B=389-607 # PDB 4B9Q X-ray; 2.40 A; A/B/C/D=1-605 # PDB 4E81 X-ray; 1.90 A; A/B=389-607 # PDB 4EZN X-ray; 1.80 A; A/B=389-607 # PDB 4EZO X-ray; 1.90 A; A/B=389-607 # PDB 4EZP X-ray; 1.65 A; A/B=389-607 # PDB 4EZQ X-ray; 2.00 A; A=389-607 # PDB 4EZR X-ray; 1.90 A; A=389-607 # PDB 4EZS X-ray; 1.90 A; A=389-607 # PDB 4EZT X-ray; 2.00 A; A=389-607 # PDB 4EZU X-ray; 1.90 A; A=389-607 # PDB 4EZV X-ray; 2.10 A; A/B=389-607 # PDB 4EZW X-ray; 1.80 A; A/B/C/D=389-607 # PDB 4EZX X-ray; 1.70 A; A/B=389-607 # PDB 4EZY X-ray; 1.85 A; A=389-607 # PDB 4EZZ X-ray; 2.05 A; A=389-607 # PDB 4F00 X-ray; 1.95 A; A=389-607 # PDB 4F01 X-ray; 1.40 A; A/B=389-607 # PDB 4HY9 X-ray; 1.55 A; A/B=389-607 # PDB 4HYB X-ray; 1.70 A; A/B=389-607 # PDB 4JN4 X-ray; 2.30 A; A/B=2-610 # PDB 4JNE X-ray; 1.96 A; A/B=2-610 # PDB 4JNF X-ray; 1.62 A; A=389-610 # PDB 4JWC X-ray; 1.80 A; A/B=389-607 # PDB 4JWD X-ray; 1.95 A; A/B=389-607 # PDB 4JWE X-ray; 1.95 A; A/B=389-607 # PDB 4JWI X-ray; 1.90 A; A/B=389-607 # PDB 4R5G X-ray; 3.45 A; A/B=389-607 # PDB 4R5I X-ray; 1.97 A; A=389-607 # PDB 4R5J X-ray; 2.36 A; A/B/C/D=389-607 # PDB 4R5K X-ray; 1.75 A; A/B=389-607 # PDB 4R5L X-ray; 2.97 A; A/B/C/D=389-607 # PIR A03311 IQECDK # PRINTS PR00301 HEATSHOCK70 # PROSITE PS00297 HSP70_1 # PROSITE PS00329 HSP70_2 # PROSITE PS01036 HSP70_3 # PTM DNAK_ECOLI Autophosphorylated; GrpE inhibits the autophosphorylation. {ECO 0000269|PubMed 1835085, ECO 0000269|PubMed 7783627, ECO 0000269|PubMed 8206983}. # Pfam PF00012 HSP70 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DNAK_ECOLI Chaperone protein DnaK # RefSeq NP_414555 NC_000913.3 # RefSeq WP_000516135 NZ_LN832404.1 # SIMILARITY Belongs to the heat shock protein 70 family. {ECO 0000305}. # SUBCELLULAR LOCATION DNAK_ECOLI Cytoplasm {ECO 0000269|PubMed 16079137}. Cell inner membrane {ECO 0000269|PubMed 16079137}; Peripheral membrane protein {ECO 0000269|PubMed 16079137}. # SUPFAM SSF100920 SSF100920 # SUPFAM SSF100934 SSF100934 # TCDB 1.A.33.1 the cation channel-forming heat shock protein-70 (hsp70) family # TIGRFAMs TIGR02350 prok_dnaK # eggNOG COG0443 LUCA # eggNOG ENOG4105CFG Bacteria BLAST swissprot:DNAK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DNAK_ECOLI BioCyc ECOL316407:JW0013-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0013-MONOMER BioCyc EcoCyc:EG10241-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10241-MONOMER BioCyc MetaCyc:EG10241-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10241-MONOMER COG COG0443 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0443 DIP DIP-35751N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35751N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1007/BF00331267 http://dx.doi.org/10.1007/BF00331267 DOI 10.1021/bi9800855 http://dx.doi.org/10.1021/bi9800855 DOI 10.1038/74062 http://dx.doi.org/10.1038/74062 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nchembio.495 http://dx.doi.org/10.1038/nchembio.495 DOI 10.1038/sj.embor.7400067 http://dx.doi.org/10.1038/sj.embor.7400067 DOI 10.1073/pnas.81.3.848 http://dx.doi.org/10.1073/pnas.81.3.848 DOI 10.1073/pnas.88.21.9513 http://dx.doi.org/10.1073/pnas.88.21.9513 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1111/j.1365-2958.1995.tb02270.x http://dx.doi.org/10.1111/j.1365-2958.1995.tb02270.x DOI 10.1111/j.1432-1033.1992.tb17237.x http://dx.doi.org/10.1111/j.1432-1033.1992.tb17237.x DOI 10.1126/science.272.5268.1606 http://dx.doi.org/10.1126/science.272.5268.1606 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D10765 http://www.ebi.ac.uk/ena/data/view/D10765 EMBL K01298 http://www.ebi.ac.uk/ena/data/view/K01298 EMBL M12565 http://www.ebi.ac.uk/ena/data/view/M12565 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0237 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0237 EcoGene EG10241 http://www.ecogene.org/geneInfo.php?eg_id=EG10241 EnsemblBacteria AAC73125 http://www.ensemblgenomes.org/id/AAC73125 EnsemblBacteria AAC73125 http://www.ensemblgenomes.org/id/AAC73125 EnsemblBacteria BAB96589 http://www.ensemblgenomes.org/id/BAB96589 EnsemblBacteria BAB96589 http://www.ensemblgenomes.org/id/BAB96589 EnsemblBacteria BAB96589 http://www.ensemblgenomes.org/id/BAB96589 EnsemblBacteria b0014 http://www.ensemblgenomes.org/id/b0014 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0016989 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016989 GO_function GO:0043531 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043531 GO_function GO:0044183 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044183 GO_function GO:0051082 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051082 GO_process GO:0006260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260 GO_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GO_process GO:0034620 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034620 GO_process GO:0043241 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043241 GO_process GO:0051085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051085 GO_process GO:0070389 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070389 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0000988 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000988 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_function GO:0051082 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051082 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 1.20.1270.10 http://www.cathdb.info/version/latest/superfamily/1.20.1270.10 Gene3D 2.60.34.10 http://www.cathdb.info/version/latest/superfamily/2.60.34.10 GeneID 944750 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944750 HAMAP MF_00332 http://hamap.expasy.org/unirule/MF_00332 HOGENOM HOG000228136 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000228136&db=HOGENOM6 InParanoid P0A6Y8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6Y8 IntAct P0A6Y8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6Y8* InterPro IPR012725 http://www.ebi.ac.uk/interpro/entry/IPR012725 InterPro IPR013126 http://www.ebi.ac.uk/interpro/entry/IPR013126 InterPro IPR018181 http://www.ebi.ac.uk/interpro/entry/IPR018181 InterPro IPR029047 http://www.ebi.ac.uk/interpro/entry/IPR029047 InterPro IPR029048 http://www.ebi.ac.uk/interpro/entry/IPR029048 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW0013 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0013 KEGG_Gene eco:b0014 http://www.genome.jp/dbget-bin/www_bget?eco:b0014 KEGG_Orthology KO:K04043 http://www.genome.jp/dbget-bin/www_bget?KO:K04043 KEGG_Pathway ko03018 http://www.genome.jp/kegg-bin/show_pathway?ko03018 KEGG_Pathway ko05152 http://www.genome.jp/kegg-bin/show_pathway?ko05152 MINT MINT-7259066 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-7259066 OMA EKMAPPQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EKMAPPQ PDB 1BPR http://www.ebi.ac.uk/pdbe-srv/view/entry/1BPR PDB 1DG4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1DG4 PDB 1DKG http://www.ebi.ac.uk/pdbe-srv/view/entry/1DKG PDB 1DKX http://www.ebi.ac.uk/pdbe-srv/view/entry/1DKX PDB 1DKY http://www.ebi.ac.uk/pdbe-srv/view/entry/1DKY PDB 1DKZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1DKZ PDB 1Q5L http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q5L PDB 2BPR http://www.ebi.ac.uk/pdbe-srv/view/entry/2BPR PDB 2KHO http://www.ebi.ac.uk/pdbe-srv/view/entry/2KHO PDB 3DPO http://www.ebi.ac.uk/pdbe-srv/view/entry/3DPO PDB 3DPP http://www.ebi.ac.uk/pdbe-srv/view/entry/3DPP PDB 3DPQ http://www.ebi.ac.uk/pdbe-srv/view/entry/3DPQ PDB 3QNJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3QNJ PDB 4B9Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4B9Q PDB 4E81 http://www.ebi.ac.uk/pdbe-srv/view/entry/4E81 PDB 4EZN http://www.ebi.ac.uk/pdbe-srv/view/entry/4EZN PDB 4EZO http://www.ebi.ac.uk/pdbe-srv/view/entry/4EZO PDB 4EZP http://www.ebi.ac.uk/pdbe-srv/view/entry/4EZP PDB 4EZQ http://www.ebi.ac.uk/pdbe-srv/view/entry/4EZQ PDB 4EZR http://www.ebi.ac.uk/pdbe-srv/view/entry/4EZR PDB 4EZS http://www.ebi.ac.uk/pdbe-srv/view/entry/4EZS PDB 4EZT http://www.ebi.ac.uk/pdbe-srv/view/entry/4EZT PDB 4EZU http://www.ebi.ac.uk/pdbe-srv/view/entry/4EZU PDB 4EZV http://www.ebi.ac.uk/pdbe-srv/view/entry/4EZV PDB 4EZW http://www.ebi.ac.uk/pdbe-srv/view/entry/4EZW PDB 4EZX http://www.ebi.ac.uk/pdbe-srv/view/entry/4EZX PDB 4EZY http://www.ebi.ac.uk/pdbe-srv/view/entry/4EZY PDB 4EZZ http://www.ebi.ac.uk/pdbe-srv/view/entry/4EZZ PDB 4F00 http://www.ebi.ac.uk/pdbe-srv/view/entry/4F00 PDB 4F01 http://www.ebi.ac.uk/pdbe-srv/view/entry/4F01 PDB 4HY9 http://www.ebi.ac.uk/pdbe-srv/view/entry/4HY9 PDB 4HYB http://www.ebi.ac.uk/pdbe-srv/view/entry/4HYB PDB 4JN4 http://www.ebi.ac.uk/pdbe-srv/view/entry/4JN4 PDB 4JNE http://www.ebi.ac.uk/pdbe-srv/view/entry/4JNE PDB 4JNF http://www.ebi.ac.uk/pdbe-srv/view/entry/4JNF PDB 4JWC http://www.ebi.ac.uk/pdbe-srv/view/entry/4JWC PDB 4JWD http://www.ebi.ac.uk/pdbe-srv/view/entry/4JWD PDB 4JWE http://www.ebi.ac.uk/pdbe-srv/view/entry/4JWE PDB 4JWI http://www.ebi.ac.uk/pdbe-srv/view/entry/4JWI PDB 4R5G http://www.ebi.ac.uk/pdbe-srv/view/entry/4R5G PDB 4R5I http://www.ebi.ac.uk/pdbe-srv/view/entry/4R5I PDB 4R5J http://www.ebi.ac.uk/pdbe-srv/view/entry/4R5J PDB 4R5K http://www.ebi.ac.uk/pdbe-srv/view/entry/4R5K PDB 4R5L http://www.ebi.ac.uk/pdbe-srv/view/entry/4R5L PDBsum 1BPR http://www.ebi.ac.uk/pdbsum/1BPR PDBsum 1DG4 http://www.ebi.ac.uk/pdbsum/1DG4 PDBsum 1DKG http://www.ebi.ac.uk/pdbsum/1DKG PDBsum 1DKX http://www.ebi.ac.uk/pdbsum/1DKX PDBsum 1DKY http://www.ebi.ac.uk/pdbsum/1DKY PDBsum 1DKZ http://www.ebi.ac.uk/pdbsum/1DKZ PDBsum 1Q5L http://www.ebi.ac.uk/pdbsum/1Q5L PDBsum 2BPR http://www.ebi.ac.uk/pdbsum/2BPR PDBsum 2KHO http://www.ebi.ac.uk/pdbsum/2KHO PDBsum 3DPO http://www.ebi.ac.uk/pdbsum/3DPO PDBsum 3DPP http://www.ebi.ac.uk/pdbsum/3DPP PDBsum 3DPQ http://www.ebi.ac.uk/pdbsum/3DPQ PDBsum 3QNJ http://www.ebi.ac.uk/pdbsum/3QNJ PDBsum 4B9Q http://www.ebi.ac.uk/pdbsum/4B9Q PDBsum 4E81 http://www.ebi.ac.uk/pdbsum/4E81 PDBsum 4EZN http://www.ebi.ac.uk/pdbsum/4EZN PDBsum 4EZO http://www.ebi.ac.uk/pdbsum/4EZO PDBsum 4EZP http://www.ebi.ac.uk/pdbsum/4EZP PDBsum 4EZQ http://www.ebi.ac.uk/pdbsum/4EZQ PDBsum 4EZR http://www.ebi.ac.uk/pdbsum/4EZR PDBsum 4EZS http://www.ebi.ac.uk/pdbsum/4EZS PDBsum 4EZT http://www.ebi.ac.uk/pdbsum/4EZT PDBsum 4EZU http://www.ebi.ac.uk/pdbsum/4EZU PDBsum 4EZV http://www.ebi.ac.uk/pdbsum/4EZV PDBsum 4EZW http://www.ebi.ac.uk/pdbsum/4EZW PDBsum 4EZX http://www.ebi.ac.uk/pdbsum/4EZX PDBsum 4EZY http://www.ebi.ac.uk/pdbsum/4EZY PDBsum 4EZZ http://www.ebi.ac.uk/pdbsum/4EZZ PDBsum 4F00 http://www.ebi.ac.uk/pdbsum/4F00 PDBsum 4F01 http://www.ebi.ac.uk/pdbsum/4F01 PDBsum 4HY9 http://www.ebi.ac.uk/pdbsum/4HY9 PDBsum 4HYB http://www.ebi.ac.uk/pdbsum/4HYB PDBsum 4JN4 http://www.ebi.ac.uk/pdbsum/4JN4 PDBsum 4JNE http://www.ebi.ac.uk/pdbsum/4JNE PDBsum 4JNF http://www.ebi.ac.uk/pdbsum/4JNF PDBsum 4JWC http://www.ebi.ac.uk/pdbsum/4JWC PDBsum 4JWD http://www.ebi.ac.uk/pdbsum/4JWD PDBsum 4JWE http://www.ebi.ac.uk/pdbsum/4JWE PDBsum 4JWI http://www.ebi.ac.uk/pdbsum/4JWI PDBsum 4R5G http://www.ebi.ac.uk/pdbsum/4R5G PDBsum 4R5I http://www.ebi.ac.uk/pdbsum/4R5I PDBsum 4R5J http://www.ebi.ac.uk/pdbsum/4R5J PDBsum 4R5K http://www.ebi.ac.uk/pdbsum/4R5K PDBsum 4R5L http://www.ebi.ac.uk/pdbsum/4R5L PRINTS PR00301 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00301 PROSITE PS00297 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00297 PROSITE PS00329 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00329 PROSITE PS01036 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01036 PSORT swissprot:DNAK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DNAK_ECOLI PSORT-B swissprot:DNAK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DNAK_ECOLI PSORT2 swissprot:DNAK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DNAK_ECOLI Pfam PF00012 http://pfam.xfam.org/family/PF00012 Phobius swissprot:DNAK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DNAK_ECOLI PhylomeDB P0A6Y8 http://phylomedb.org/?seqid=P0A6Y8 ProteinModelPortal P0A6Y8 http://www.proteinmodelportal.org/query/uniprot/P0A6Y8 PubMed 10742174 http://www.ncbi.nlm.nih.gov/pubmed/10742174 PubMed 1396676 http://www.ncbi.nlm.nih.gov/pubmed/1396676 PubMed 14726952 http://www.ncbi.nlm.nih.gov/pubmed/14726952 PubMed 1592823 http://www.ncbi.nlm.nih.gov/pubmed/1592823 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1835085 http://www.ncbi.nlm.nih.gov/pubmed/1835085 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 21151122 http://www.ncbi.nlm.nih.gov/pubmed/21151122 PubMed 2674651 http://www.ncbi.nlm.nih.gov/pubmed/2674651 PubMed 3003084 http://www.ncbi.nlm.nih.gov/pubmed/3003084 PubMed 3003085 http://www.ncbi.nlm.nih.gov/pubmed/3003085 PubMed 6322174 http://www.ncbi.nlm.nih.gov/pubmed/6322174 PubMed 7783627 http://www.ncbi.nlm.nih.gov/pubmed/7783627 PubMed 8206983 http://www.ncbi.nlm.nih.gov/pubmed/8206983 PubMed 8658133 http://www.ncbi.nlm.nih.gov/pubmed/8658133 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9609686 http://www.ncbi.nlm.nih.gov/pubmed/9609686 RefSeq NP_414555 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414555 RefSeq WP_000516135 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000516135 SMR P0A6Y8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6Y8 STRING 511145.b0014 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0014&targetmode=cogs STRING COG0443 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0443&targetmode=cogs SUPFAM SSF100920 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF100920 SUPFAM SSF100934 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF100934 SWISS-2DPAGE P0A6Y8 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A6Y8 TCDB 1.A.33.1 http://www.tcdb.org/search/result.php?tc=1.A.33.1 TIGRFAMs TIGR02350 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02350 UniProtKB DNAK_ECOLI http://www.uniprot.org/uniprot/DNAK_ECOLI UniProtKB-AC P0A6Y8 http://www.uniprot.org/uniprot/P0A6Y8 charge swissprot:DNAK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DNAK_ECOLI eggNOG COG0443 http://eggnogapi.embl.de/nog_data/html/tree/COG0443 eggNOG ENOG4105CFG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CFG epestfind swissprot:DNAK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DNAK_ECOLI garnier swissprot:DNAK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DNAK_ECOLI helixturnhelix swissprot:DNAK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DNAK_ECOLI hmoment swissprot:DNAK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DNAK_ECOLI iep swissprot:DNAK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DNAK_ECOLI inforesidue swissprot:DNAK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DNAK_ECOLI octanol swissprot:DNAK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DNAK_ECOLI pepcoil swissprot:DNAK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DNAK_ECOLI pepdigest swissprot:DNAK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DNAK_ECOLI pepinfo swissprot:DNAK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DNAK_ECOLI pepnet swissprot:DNAK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DNAK_ECOLI pepstats swissprot:DNAK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DNAK_ECOLI pepwheel swissprot:DNAK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DNAK_ECOLI pepwindow swissprot:DNAK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DNAK_ECOLI sigcleave swissprot:DNAK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DNAK_ECOLI ## Database ID URL or Descriptions # AltName Kdo(2)-lipid IV(A) lauroyltransferase {ECO:0000255|HAMAP-Rule MF_01942} # BIOPHYSICOCHEMICAL PROPERTIES LPXL_ECOLI Kinetic parameters KM=7 uM for lauroyl-ACP {ECO 0000269|PubMed 18656959}; KM=15 uM for Kdo(2)-lipid IV(A) {ECO 0000269|PubMed 18656959}; Vmax=95 umol/min/mg enzyme toward lauroyl-ACP {ECO 0000269|PubMed 18656959}; Vmax=221 umol/min/mg enzyme toward Kdo(2)-lipid IV(A) {ECO 0000269|PubMed 18656959}; # BRENDA 2.3.1.B29 2026 # BioGrid 4262842 69 # CATALYTIC ACTIVITY LPXL_ECOLI A dodecanoyl-[acyl-carrier protein] + alpha- Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IV(A) = (Kdo)(2)-(dodecanoyl)- lipid IV(A) + a holo-[acyl-carrier protein]. {ECO 0000255|HAMAP- Rule MF_01942, ECO 0000269|PubMed 18656959}. # CDD cd07984 LPLAT_LABLAT-like # DISRUPTION PHENOTYPE Inactivation leads to bacterial death at temperatures above 33 degrees Celsius. Phenotype at nonpermissive temperatures includes an arrest of cell division followed by the formation of bulges or filaments. {ECO:0000269|PubMed 1846149}. # EcoGene EG10464 lpxL # FUNCTION LPXL_ECOLI Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (lauroyl)-lipid IV(A). Has 10 fold selectivity for lauroyl-ACP over myristoyl-ACP. In vitro, can also catalyze a slow second acylation reaction leading to the formation of Kdo(2)-(dilauroyl)- lipid IV(A). {ECO 0000269|PubMed 18656959, ECO 0000269|PubMed 2203778, ECO 0000269|PubMed 8662613}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IEA:UniProtKB-HAMAP. # GO_component GO:0016020 membrane; IDA:EcoliWiki. # GO_function GO:0008913 lauroyltransferase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0016740 transferase activity; IDA:EcoCyc. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0009245 lipid A biosynthetic process; IMP:EcoliWiki. # GO_process GO:0036104 Kdo2-lipid A biosynthetic process; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # HAMAP MF_01942 Lipid_A_LpxL_LpxP # INDUCTION Is expressed at all temperatures, but accumulation of htrB transcripts slightly declines with raising temperature. Thus, its expression is not induced by heat shock. {ECO:0000269|PubMed 1840644}. # IntAct P0ACV0 9 # InterPro IPR004960 LipA_acyltrans # InterPro IPR011920 Lipid_A_LpxL_LpxP # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # KEGG_Pathway ko00540 Lipopolysaccharide biosynthesis # Organism LPXL_ECOLI Escherichia coli (strain K12) # PATHWAY LPXL_ECOLI Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. {ECO 0000255|HAMAP-Rule MF_01942, ECO 0000269|PubMed 18656959, ECO 0000269|PubMed 2203778, ECO 0000269|PubMed 8662613}. # PATHWAY LPXL_ECOLI Glycolipid biosynthesis; KDO(2)-lipid A biosynthesis; KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A) step 3/4. {ECO 0000255|HAMAP-Rule MF_01942, ECO 0000269|PubMed 18656959, ECO 0000269|PubMed 2203778, ECO 0000269|PubMed 8662613}. # PATRIC 32117345 VBIEscCol129921_1095 # PIR S16888 S16888 # PIRSF PIRSF026649 MsbB # Pfam PF03279 Lip_A_acyltrans # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LPXL_ECOLI Lipid A biosynthesis lauroyltransferase {ECO 0000255|HAMAP-Rule MF_01942, ECO 0000303|PubMed 18656959} # RefSeq NP_415572 NC_000913.3 # RefSeq WP_000183364 NZ_LN832404.1 # SIMILARITY Belongs to the LpxL/LpxM/LpxP family. {ECO:0000255|HAMAP-Rule MF_01942, ECO:0000305}. # SUBCELLULAR LOCATION LPXL_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01942, ECO 0000269|PubMed 1846149, ECO 0000269|PubMed 18656959, ECO 0000269|PubMed 8662613}; Single- pass membrane protein {ECO 0000255|HAMAP-Rule MF_01942}. # SUBUNIT Monomer. {ECO:0000269|PubMed 18656959}. # TIGRFAMs TIGR02207 lipid_A_htrB # UniPathway UPA00360 UER00485 # eggNOG COG1560 LUCA # eggNOG ENOG4105D1S Bacteria BLAST swissprot:LPXL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LPXL_ECOLI BioCyc ECOL316407:JW1041-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1041-MONOMER BioCyc EcoCyc:LAUROYLACYLTRAN-MONOMER http://biocyc.org/getid?id=EcoCyc:LAUROYLACYLTRAN-MONOMER BioCyc MetaCyc:LAUROYLACYLTRAN-MONOMER http://biocyc.org/getid?id=MetaCyc:LAUROYLACYLTRAN-MONOMER COG COG1560 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1560 DOI 10.1021/bi800873n http://dx.doi.org/10.1021/bi800873n DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.271.20.12095 http://dx.doi.org/10.1074/jbc.271.20.12095 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1991.tb02159.x http://dx.doi.org/10.1111/j.1365-2958.1991.tb02159.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.241 {ECO:0000255|HAMAP-Rule:MF_01942, ECO:0000269|PubMed:18656959} http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.241 {ECO:0000255|HAMAP-Rule:MF_01942, ECO:0000269|PubMed:18656959} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X59939 http://www.ebi.ac.uk/ena/data/view/X59939 EMBL X61000 http://www.ebi.ac.uk/ena/data/view/X61000 ENZYME 2.3.1.241 {ECO:0000255|HAMAP-Rule:MF_01942, ECO:0000269|PubMed:18656959} http://enzyme.expasy.org/EC/2.3.1.241 {ECO:0000255|HAMAP-Rule:MF_01942, ECO:0000269|PubMed:18656959} EchoBASE EB0459 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0459 EcoGene EG10464 http://www.ecogene.org/geneInfo.php?eg_id=EG10464 EnsemblBacteria AAC74138 http://www.ensemblgenomes.org/id/AAC74138 EnsemblBacteria AAC74138 http://www.ensemblgenomes.org/id/AAC74138 EnsemblBacteria BAA35852 http://www.ensemblgenomes.org/id/BAA35852 EnsemblBacteria BAA35852 http://www.ensemblgenomes.org/id/BAA35852 EnsemblBacteria BAA35852 http://www.ensemblgenomes.org/id/BAA35852 EnsemblBacteria b1054 http://www.ensemblgenomes.org/id/b1054 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0008913 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008913 GO_function GO:0016740 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016740 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GO_process GO:0009245 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009245 GO_process GO:0036104 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036104 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 946216 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946216 HAMAP MF_01942 http://hamap.expasy.org/unirule/MF_01942 HOGENOM HOG000265960 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000265960&db=HOGENOM6 InParanoid P0ACV0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACV0 IntAct P0ACV0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACV0* IntEnz 2.3.1.241 {ECO:0000255|HAMAP-Rule:MF_01942, ECO:0000269|PubMed:18656959} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.241 {ECO:0000255|HAMAP-Rule:MF_01942, ECO:0000269|PubMed:18656959} InterPro IPR004960 http://www.ebi.ac.uk/interpro/entry/IPR004960 InterPro IPR011920 http://www.ebi.ac.uk/interpro/entry/IPR011920 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Gene ecj:JW1041 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1041 KEGG_Gene eco:b1054 http://www.genome.jp/dbget-bin/www_bget?eco:b1054 KEGG_Orthology KO:K02517 http://www.genome.jp/dbget-bin/www_bget?KO:K02517 KEGG_Pathway ko00540 http://www.genome.jp/kegg-bin/show_pathway?ko00540 KEGG_Reaction rn:R05146 http://www.genome.jp/dbget-bin/www_bget?rn:R05146 OMA ILCLPYP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ILCLPYP PSORT swissprot:LPXL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LPXL_ECOLI PSORT-B swissprot:LPXL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LPXL_ECOLI PSORT2 swissprot:LPXL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LPXL_ECOLI Pfam PF03279 http://pfam.xfam.org/family/PF03279 Phobius swissprot:LPXL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LPXL_ECOLI PhylomeDB P0ACV0 http://phylomedb.org/?seqid=P0ACV0 ProteinModelPortal P0ACV0 http://www.proteinmodelportal.org/query/uniprot/P0ACV0 PubMed 1537791 http://www.ncbi.nlm.nih.gov/pubmed/1537791 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1840644 http://www.ncbi.nlm.nih.gov/pubmed/1840644 PubMed 1846149 http://www.ncbi.nlm.nih.gov/pubmed/1846149 PubMed 18656959 http://www.ncbi.nlm.nih.gov/pubmed/18656959 PubMed 2203778 http://www.ncbi.nlm.nih.gov/pubmed/2203778 PubMed 8662613 http://www.ncbi.nlm.nih.gov/pubmed/8662613 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415572 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415572 RefSeq WP_000183364 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000183364 SMR P0ACV0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACV0 STRING 511145.b1054 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1054&targetmode=cogs STRING COG1560 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1560&targetmode=cogs TIGRFAMs TIGR02207 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02207 UniProtKB LPXL_ECOLI http://www.uniprot.org/uniprot/LPXL_ECOLI UniProtKB-AC P0ACV0 http://www.uniprot.org/uniprot/P0ACV0 charge swissprot:LPXL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LPXL_ECOLI eggNOG COG1560 http://eggnogapi.embl.de/nog_data/html/tree/COG1560 eggNOG ENOG4105D1S http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D1S epestfind swissprot:LPXL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LPXL_ECOLI garnier swissprot:LPXL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LPXL_ECOLI helixturnhelix swissprot:LPXL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LPXL_ECOLI hmoment swissprot:LPXL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LPXL_ECOLI iep swissprot:LPXL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LPXL_ECOLI inforesidue swissprot:LPXL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LPXL_ECOLI octanol swissprot:LPXL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LPXL_ECOLI pepcoil swissprot:LPXL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LPXL_ECOLI pepdigest swissprot:LPXL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LPXL_ECOLI pepinfo swissprot:LPXL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LPXL_ECOLI pepnet swissprot:LPXL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LPXL_ECOLI pepstats swissprot:LPXL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LPXL_ECOLI pepwheel swissprot:LPXL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LPXL_ECOLI pepwindow swissprot:LPXL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LPXL_ECOLI sigcleave swissprot:LPXL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LPXL_ECOLI ## Database ID URL or Descriptions # AltName Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase {ECO:0000255|HAMAP-Rule MF_00033} # BRENDA 2.4.1.227 2026 # BioGrid 4261859 551 # CATALYTIC ACTIVITY UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala- gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)- diphosphoundecaprenol. {ECO:0000255|HAMAP-Rule MF_00033}. # CAZy GT28 Glycosyltransferase Family 28 # CDD cd03785 GT1_MurG # EcoGene EG10623 murG # FUNCTION MURG_ECOLI Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II). # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_function GO:0050511 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity; IDA:EcoliWiki. # GO_function MURG_ECOLI GO 0051991 UDP-N-acetyl-D-glucosamine N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity; IEA UniProtKB-EC. # GO_process GO:0005975 carbohydrate metabolic process; IEA:InterPro. # GO_process GO:0007049 cell cycle; IEA:UniProtKB-KW. # GO_process GO:0008360 regulation of cell shape; IEA:UniProtKB-KW. # GO_process GO:0009252 peptidoglycan biosynthetic process; IMP:EcoCyc. # GO_process GO:0030259 lipid glycosylation; IEA:UniProtKB-HAMAP. # GO_process GO:0051301 cell division; IEA:UniProtKB-KW. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0007049 cell cycle # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0051301 cell division # GOslim_process GO:0071554 cell wall organization or biogenesis # HAMAP MF_00033 MurG # IntAct P17443 26 # InterPro IPR004276 GlycoTrans_28_N # InterPro IPR006009 GlcNAc_MurG # InterPro IPR007235 Glyco_trans_28_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00550 Peptidoglycan biosynthesis # KEGG_Pathway ko04112 Cell cycle - Caulobacter # Organism MURG_ECOLI Escherichia coli (strain K12) # PATHWAY Cell wall biogenesis; peptidoglycan biosynthesis. {ECO:0000255|HAMAP-Rule MF_00033}. # PATRIC 32115285 VBIEscCol129921_0094 # PDB 1F0K X-ray; 1.90 A; A/B=1-355 # PDB 1NLM X-ray; 2.50 A; A/B=2-355 # PIR JQ0544 BVECMG # Pfam PF03033 Glyco_transf_28 # Pfam PF04101 Glyco_tran_28_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase {ECO:0000255|HAMAP-Rule MF_00033} # RefSeq NP_414632 NC_000913.3 # RefSeq WP_000016560 NZ_LN832404.1 # SIMILARITY Belongs to the glycosyltransferase 28 family. MurG subfamily. {ECO:0000255|HAMAP-Rule MF_00033}. # SUBCELLULAR LOCATION MURG_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_00033, ECO 0000269|PubMed 8449890}; Peripheral membrane protein {ECO 0000255|HAMAP-Rule MF_00033, ECO 0000269|PubMed 8449890}. # TIGRFAMs TIGR01133 murG # eggNOG COG0707 LUCA # eggNOG ENOG4105DVQ Bacteria BLAST swissprot:MURG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MURG_ECOLI BioCyc ECOL316407:JW0088-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0088-MONOMER BioCyc EcoCyc:NACGLCTRANS-MONOMER http://biocyc.org/getid?id=EcoCyc:NACGLCTRANS-MONOMER BioCyc MetaCyc:NACGLCTRANS-MONOMER http://biocyc.org/getid?id=MetaCyc:NACGLCTRANS-MONOMER COG COG0707 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0707 DIP DIP-10282N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10282N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/18.13.4014 http://dx.doi.org/10.1093/nar/18.13.4014 DOI 10.1093/nar/18.9.2810 http://dx.doi.org/10.1093/nar/18.9.2810 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1110/ps.9.6.1045 http://dx.doi.org/10.1110/ps.9.6.1045 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.4.1.227 {ECO:0000255|HAMAP-Rule:MF_00033} http://www.genome.jp/dbget-bin/www_bget?EC:2.4.1.227 {ECO:0000255|HAMAP-Rule:MF_00033} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X52540 http://www.ebi.ac.uk/ena/data/view/X52540 EMBL X52644 http://www.ebi.ac.uk/ena/data/view/X52644 EMBL X55034 http://www.ebi.ac.uk/ena/data/view/X55034 ENZYME 2.4.1.227 {ECO:0000255|HAMAP-Rule:MF_00033} http://enzyme.expasy.org/EC/2.4.1.227 {ECO:0000255|HAMAP-Rule:MF_00033} EchoBASE EB0618 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0618 EcoGene EG10623 http://www.ecogene.org/geneInfo.php?eg_id=EG10623 EnsemblBacteria AAC73201 http://www.ensemblgenomes.org/id/AAC73201 EnsemblBacteria AAC73201 http://www.ensemblgenomes.org/id/AAC73201 EnsemblBacteria BAB96658 http://www.ensemblgenomes.org/id/BAB96658 EnsemblBacteria BAB96658 http://www.ensemblgenomes.org/id/BAB96658 EnsemblBacteria BAB96658 http://www.ensemblgenomes.org/id/BAB96658 EnsemblBacteria b0090 http://www.ensemblgenomes.org/id/b0090 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0050511 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050511 GO_function GO:0051991 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051991 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GO_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0009252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009252 GO_process GO:0030259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030259 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 GeneID 946321 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946321 HAMAP MF_00033 http://hamap.expasy.org/unirule/MF_00033 HOGENOM HOG000218321 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218321&db=HOGENOM6 InParanoid P17443 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P17443 IntAct P17443 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P17443* IntEnz 2.4.1.227 {ECO:0000255|HAMAP-Rule:MF_00033} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.1.227 {ECO:0000255|HAMAP-Rule:MF_00033} InterPro IPR004276 http://www.ebi.ac.uk/interpro/entry/IPR004276 InterPro IPR006009 http://www.ebi.ac.uk/interpro/entry/IPR006009 InterPro IPR007235 http://www.ebi.ac.uk/interpro/entry/IPR007235 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0088 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0088 KEGG_Gene eco:b0090 http://www.genome.jp/dbget-bin/www_bget?eco:b0090 KEGG_Orthology KO:K02563 http://www.genome.jp/dbget-bin/www_bget?KO:K02563 KEGG_Pathway ko00550 http://www.genome.jp/kegg-bin/show_pathway?ko00550 KEGG_Pathway ko04112 http://www.genome.jp/kegg-bin/show_pathway?ko04112 KEGG_Reaction rn:R05032 http://www.genome.jp/dbget-bin/www_bget?rn:R05032 KEGG_Reaction rn:R05662 http://www.genome.jp/dbget-bin/www_bget?rn:R05662 MINT MINT-1233082 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1233082 OMA HQTKNAM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HQTKNAM PDB 1F0K http://www.ebi.ac.uk/pdbe-srv/view/entry/1F0K PDB 1NLM http://www.ebi.ac.uk/pdbe-srv/view/entry/1NLM PDBsum 1F0K http://www.ebi.ac.uk/pdbsum/1F0K PDBsum 1NLM http://www.ebi.ac.uk/pdbsum/1NLM PSORT swissprot:MURG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MURG_ECOLI PSORT-B swissprot:MURG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MURG_ECOLI PSORT2 swissprot:MURG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MURG_ECOLI Pfam PF03033 http://pfam.xfam.org/family/PF03033 Pfam PF04101 http://pfam.xfam.org/family/PF04101 Phobius swissprot:MURG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MURG_ECOLI PhylomeDB P17443 http://phylomedb.org/?seqid=P17443 ProteinModelPortal P17443 http://www.proteinmodelportal.org/query/uniprot/P17443 PubMed 10892798 http://www.ncbi.nlm.nih.gov/pubmed/10892798 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 1649817 http://www.ncbi.nlm.nih.gov/pubmed/1649817 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2187180 http://www.ncbi.nlm.nih.gov/pubmed/2187180 PubMed 2197603 http://www.ncbi.nlm.nih.gov/pubmed/2197603 PubMed 8449890 http://www.ncbi.nlm.nih.gov/pubmed/8449890 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414632 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414632 RefSeq WP_000016560 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000016560 SMR P17443 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P17443 STRING 511145.b0090 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0090&targetmode=cogs STRING COG0707 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0707&targetmode=cogs TIGRFAMs TIGR01133 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01133 UniProtKB MURG_ECOLI http://www.uniprot.org/uniprot/MURG_ECOLI UniProtKB-AC P17443 http://www.uniprot.org/uniprot/P17443 charge swissprot:MURG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MURG_ECOLI eggNOG COG0707 http://eggnogapi.embl.de/nog_data/html/tree/COG0707 eggNOG ENOG4105DVQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DVQ epestfind swissprot:MURG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MURG_ECOLI garnier swissprot:MURG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MURG_ECOLI helixturnhelix swissprot:MURG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MURG_ECOLI hmoment swissprot:MURG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MURG_ECOLI iep swissprot:MURG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MURG_ECOLI inforesidue swissprot:MURG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MURG_ECOLI octanol swissprot:MURG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MURG_ECOLI pepcoil swissprot:MURG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MURG_ECOLI pepdigest swissprot:MURG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MURG_ECOLI pepinfo swissprot:MURG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MURG_ECOLI pepnet swissprot:MURG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MURG_ECOLI pepstats swissprot:MURG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MURG_ECOLI pepwheel swissprot:MURG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MURG_ECOLI pepwindow swissprot:MURG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MURG_ECOLI sigcleave swissprot:MURG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MURG_ECOLI ## Database ID URL or Descriptions # EcoGene EG40008 insH3 # FUNCTION INSH3_ECOLI Involved in the transposition of the insertion sequence IS5. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # InterPro IPR002559 Transposase_11 # InterPro IPR008490 Transposase_InsH_N # Organism INSH3_ECOLI Escherichia coli (strain K12) # Pfam PF01609 DDE_Tnp_1 # Pfam PF05598 DUF772 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSH3_ECOLI Transposase InsH for insertion sequence element IS5D # RefSeq NP_414793 NC_000913.3 # RefSeq NP_415084 NC_000913.3 # RefSeq NP_415189 NC_000913.3 # RefSeq NP_415847 NC_000913.3 # RefSeq NP_416535 NC_000913.3 # RefSeq NP_416696 NC_000913.3 # RefSeq NP_417456 NC_000913.3 # RefSeq NP_417685 NC_000913.3 # RefSeq NP_417962 NC_000913.3 # SIMILARITY Belongs to the transposase 11 family. {ECO 0000305}. # eggNOG COG3039 LUCA # eggNOG ENOG4105F2I Bacteria BLAST swissprot:INSH3_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSH3_ECOLI BioCyc EcoCyc:MONOMER0-4235 http://biocyc.org/getid?id=EcoCyc:MONOMER0-4235 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB4718 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4718 EcoGene EG40008 http://www.ecogene.org/geneInfo.php?eg_id=EG40008 EnsemblBacteria AAC73757 http://www.ensemblgenomes.org/id/AAC73757 EnsemblBacteria AAC73757 http://www.ensemblgenomes.org/id/AAC73757 EnsemblBacteria BAE76356 http://www.ensemblgenomes.org/id/BAE76356 EnsemblBacteria BAE76356 http://www.ensemblgenomes.org/id/BAE76356 EnsemblBacteria BAE76356 http://www.ensemblgenomes.org/id/BAE76356 EnsemblBacteria b0656 http://www.ensemblgenomes.org/id/b0656 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GeneID 944917 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944917 GeneID 944941 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944941 GeneID 945896 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945896 GeneID 946163 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946163 GeneID 946577 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946577 GeneID 947516 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947516 GeneID 947743 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947743 GeneID 948015 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948015 GeneID 949121 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949121 InParanoid P0CE51 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CE51 InterPro IPR002559 http://www.ebi.ac.uk/interpro/entry/IPR002559 InterPro IPR008490 http://www.ebi.ac.uk/interpro/entry/IPR008490 KEGG_Gene ecj:JW0652 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0652 KEGG_Gene eco:b0259 http://www.genome.jp/dbget-bin/www_bget?eco:b0259 KEGG_Gene eco:b0552 http://www.genome.jp/dbget-bin/www_bget?eco:b0552 KEGG_Gene eco:b0656 http://www.genome.jp/dbget-bin/www_bget?eco:b0656 KEGG_Gene eco:b1331 http://www.genome.jp/dbget-bin/www_bget?eco:b1331 KEGG_Gene eco:b2030 http://www.genome.jp/dbget-bin/www_bget?eco:b2030 KEGG_Gene eco:b2192 http://www.genome.jp/dbget-bin/www_bget?eco:b2192 KEGG_Gene eco:b2982 http://www.genome.jp/dbget-bin/www_bget?eco:b2982 KEGG_Gene eco:b3218 http://www.genome.jp/dbget-bin/www_bget?eco:b3218 KEGG_Gene eco:b3505 http://www.genome.jp/dbget-bin/www_bget?eco:b3505 PSORT swissprot:INSH3_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSH3_ECOLI PSORT-B swissprot:INSH3_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSH3_ECOLI PSORT2 swissprot:INSH3_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSH3_ECOLI Pfam PF01609 http://pfam.xfam.org/family/PF01609 Pfam PF05598 http://pfam.xfam.org/family/PF05598 Phobius swissprot:INSH3_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSH3_ECOLI PhylomeDB P0CE51 http://phylomedb.org/?seqid=P0CE51 ProteinModelPortal P0CE51 http://www.proteinmodelportal.org/query/uniprot/P0CE51 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414793 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414793 RefSeq NP_415084 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415084 RefSeq NP_415189 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415189 RefSeq NP_415847 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415847 RefSeq NP_416535 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416535 RefSeq NP_416696 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416696 RefSeq NP_417456 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417456 RefSeq NP_417685 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417685 RefSeq NP_417962 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417962 SMR P0CE51 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0CE51 STRING 511145.b3505 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3505&targetmode=cogs UniProtKB INSH3_ECOLI http://www.uniprot.org/uniprot/INSH3_ECOLI UniProtKB-AC P0CE51 http://www.uniprot.org/uniprot/P0CE51 charge swissprot:INSH3_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSH3_ECOLI eggNOG COG3039 http://eggnogapi.embl.de/nog_data/html/tree/COG3039 eggNOG ENOG4105F2I http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F2I epestfind swissprot:INSH3_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSH3_ECOLI garnier swissprot:INSH3_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSH3_ECOLI helixturnhelix swissprot:INSH3_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSH3_ECOLI hmoment swissprot:INSH3_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSH3_ECOLI iep swissprot:INSH3_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSH3_ECOLI inforesidue swissprot:INSH3_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSH3_ECOLI octanol swissprot:INSH3_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSH3_ECOLI pepcoil swissprot:INSH3_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSH3_ECOLI pepdigest swissprot:INSH3_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSH3_ECOLI pepinfo swissprot:INSH3_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSH3_ECOLI pepnet swissprot:INSH3_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSH3_ECOLI pepstats swissprot:INSH3_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSH3_ECOLI pepwheel swissprot:INSH3_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSH3_ECOLI pepwindow swissprot:INSH3_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSH3_ECOLI sigcleave swissprot:INSH3_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSH3_ECOLI ## Database ID URL or Descriptions # BioGrid 4261713 10 # EcoGene EG12843 ybaN # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR007401 DUF454 # Organism YBAN_ECOLI Escherichia coli (strain K12) # PATRIC 32116091 VBIEscCol129921_0487 # PIR C64777 C64777 # PIRSF PIRSF016789 DUF454 # Pfam PF04304 DUF454 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBAN_ECOLI Inner membrane protein YbaN # RefSeq NP_415001 NC_000913.3 # RefSeq WP_001188905 NZ_LN832404.1 # SUBCELLULAR LOCATION YBAN_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG COG2832 LUCA # eggNOG ENOG4105WD1 Bacteria BLAST swissprot:YBAN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBAN_ECOLI BioCyc ECOL316407:JW0457-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0457-MONOMER BioCyc EcoCyc:EG12843-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12843-MONOMER COG COG2832 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2832 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D13958 http://www.ebi.ac.uk/ena/data/view/D13958 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U38660 http://www.ebi.ac.uk/ena/data/view/U38660 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EchoBASE EB2692 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2692 EcoGene EG12843 http://www.ecogene.org/geneInfo.php?eg_id=EG12843 EnsemblBacteria AAC73570 http://www.ensemblgenomes.org/id/AAC73570 EnsemblBacteria AAC73570 http://www.ensemblgenomes.org/id/AAC73570 EnsemblBacteria BAE76247 http://www.ensemblgenomes.org/id/BAE76247 EnsemblBacteria BAE76247 http://www.ensemblgenomes.org/id/BAE76247 EnsemblBacteria BAE76247 http://www.ensemblgenomes.org/id/BAE76247 EnsemblBacteria b0468 http://www.ensemblgenomes.org/id/b0468 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 945558 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945558 HOGENOM HOG000277594 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000277594&db=HOGENOM6 InParanoid P0AAR5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAR5 InterPro IPR007401 http://www.ebi.ac.uk/interpro/entry/IPR007401 KEGG_Gene ecj:JW0457 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0457 KEGG_Gene eco:b0468 http://www.genome.jp/dbget-bin/www_bget?eco:b0468 KEGG_Orthology KO:K09790 http://www.genome.jp/dbget-bin/www_bget?KO:K09790 OMA GSYLRHW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GSYLRHW PSORT swissprot:YBAN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBAN_ECOLI PSORT-B swissprot:YBAN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBAN_ECOLI PSORT2 swissprot:YBAN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBAN_ECOLI Pfam PF04304 http://pfam.xfam.org/family/PF04304 Phobius swissprot:YBAN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBAN_ECOLI PhylomeDB P0AAR5 http://phylomedb.org/?seqid=P0AAR5 ProteinModelPortal P0AAR5 http://www.proteinmodelportal.org/query/uniprot/P0AAR5 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1856227 http://www.ncbi.nlm.nih.gov/pubmed/1856227 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415001 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415001 RefSeq WP_001188905 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001188905 STRING 511145.b0468 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0468&targetmode=cogs STRING COG2832 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2832&targetmode=cogs UniProtKB YBAN_ECOLI http://www.uniprot.org/uniprot/YBAN_ECOLI UniProtKB-AC P0AAR5 http://www.uniprot.org/uniprot/P0AAR5 charge swissprot:YBAN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBAN_ECOLI eggNOG COG2832 http://eggnogapi.embl.de/nog_data/html/tree/COG2832 eggNOG ENOG4105WD1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105WD1 epestfind swissprot:YBAN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBAN_ECOLI garnier swissprot:YBAN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBAN_ECOLI helixturnhelix swissprot:YBAN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBAN_ECOLI hmoment swissprot:YBAN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBAN_ECOLI iep swissprot:YBAN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBAN_ECOLI inforesidue swissprot:YBAN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBAN_ECOLI octanol swissprot:YBAN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBAN_ECOLI pepcoil swissprot:YBAN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBAN_ECOLI pepdigest swissprot:YBAN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBAN_ECOLI pepinfo swissprot:YBAN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBAN_ECOLI pepnet swissprot:YBAN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBAN_ECOLI pepstats swissprot:YBAN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBAN_ECOLI pepwheel swissprot:YBAN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBAN_ECOLI pepwindow swissprot:YBAN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBAN_ECOLI sigcleave swissprot:YBAN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBAN_ECOLI ## Database ID URL or Descriptions # AltName CYDB_ECOLI Cytochrome bd-I oxidase subunit II # AltName CYDB_ECOLI Cytochrome d ubiquinol oxidase subunit II # BIOPHYSICOCHEMICAL PROPERTIES CYDB_ECOLI Kinetic parameters KM=0.1 mM for ubiquinol-1 {ECO 0000269|PubMed 6307994}; KM=0.28 mM for 2,3,5,6-tetramethyl-p-phenylenediamine {ECO 0000269|PubMed 6307994}; KM=0.68 mM for N,N,N',N'-tetramethyl-p-phenylenediamine {ECO 0000269|PubMed 6307994}; Vmax=383 umol/min/mg enzyme for ubiquinol-1 {ECO 0000269|PubMed 6307994}; Vmax=270 umol/min/mg enzyme for 2,3,5,6-tetramethyl-p- phenylenediamine {ECO 0000269|PubMed 6307994}; Vmax=126 umol/min/mg enzyme for N,N,N',N'-tetramethyl-p- phenylenediamine {ECO 0000269|PubMed 6307994}; Note=pH 7.0, 37 degrees Celsius.; # BRENDA 1.10.3.14 2026 # BioGrid 4263540 347 # CATALYTIC ACTIVITY CYDB_ECOLI 2 ubiquinol + O(2) + 4 H(+)(Side 1) = 2 ubiquinone + 2 H(2)O + 4 H(+)(Side 2). # COFACTOR Name=heme b; Xref=ChEBI:CHEBI 60344; Note=Binds 1 protoheme IX center (heme b595, originally called cytochrome a1) per heterodimer, in conjunction with CydA.; # COFACTOR Name=heme d cis-diol; Xref=ChEBI:CHEBI 62814; Note=Binds 1 iron-chlorin (heme d or cytochrome d) per heterodimer, in conjunction with CydA.; # DISRUPTION PHENOTYPE CYDB_ECOLI Loss of cytochrome b595 and d from enzyme preparations (PubMed 3013298). A double cydA/cydB deletion shows increased sensitivity to reductant (beta-mercapoethanol) (PubMed 23749980). Greatly increased resistance to hydroxyurea, probably due to decreased OH radical formation as an electron transport chain is disrupted (PubMed 20005847). {ECO 0000269|PubMed 19542282, ECO 0000269|PubMed 20005847, ECO 0000269|PubMed 21987791, ECO 0000269|PubMed 23749980, ECO 0000269|PubMed 3013298}. # ENZYME REGULATION 90% inhibited by cyanide and 2-heptyl-4- hydroxyquinoline N-oxide, at 1 mM and 40 uM respectively. {ECO:0000269|PubMed 6307994}. # EcoGene EG10174 cydB # FUNCTION CYDB_ECOLI A terminal oxidase that produces a proton motive force by the vectorial transfer of protons across the inner membrane. It is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at low aeration. Generates a proton motive force using protons and electrons from opposite sides of the membrane to generate H(2)O, transferring 1 proton/electron. {ECO 0000269|PubMed 19542282, ECO 0000269|PubMed 21987791, ECO 0000269|PubMed 6307994}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; ISM:EcoCyc. # GO_component GO:0016020 membrane; IDA:EcoCyc. # GO_component GO:0070069 cytochrome complex; IDA:EcoCyc. # GO_function GO:0009055 electron carrier activity; IDA:EcoCyc. # GO_function GO:0016682 oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor; IDA:EcoCyc. # GO_function GO:0020037 heme binding; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006119 oxidative phosphorylation; IEA:UniProtKB-UniPathway. # GO_process GO:0019646 aerobic electron transport chain; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # INDUCTION Under conditions of low aeration, in stationary phase (at protein level). {ECO:0000269|PubMed 6307994}. # INTERACTION CYDB_ECOLI P0ABJ9 cydA; NbExp=5; IntAct=EBI-1213195, EBI-906928; # IntAct P0ABK2 2 # InterPro IPR003317 Cyt-d_oxidase_su2 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00190 Oxidative phosphorylation # KEGG_Pathway ko02020 Two-component system # Organism CYDB_ECOLI Escherichia coli (strain K12) # PATHWAY CYDB_ECOLI Energy metabolism; oxidative phosphorylation. # PATRIC 32116665 VBIEscCol129921_0765 # PIR B28940 B28940 # PIRSF PIRSF000267 Cyt_oxidse_sub2 # PTM CYDB_ECOLI The N-terminus is blocked. # Pfam PF02322 Cyt_bd_oxida_II # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CYDB_ECOLI Cytochrome bd-I ubiquinol oxidase subunit 2 # RefSeq NP_415262 NC_000913.3 # RefSeq WP_000568275 NZ_LN832404.1 # SIMILARITY Belongs to the cytochrome ubiquinol oxidase subunit 2 family. {ECO 0000305}. # SUBCELLULAR LOCATION CYDB_ECOLI Cell inner membrane {ECO 0000269|PubMed 15013751, ECO 0000269|PubMed 16079137}; Multi- pass membrane protein {ECO 0000269|PubMed 15013751, ECO 0000269|PubMed 16079137}. Note=The displayed topology is based on (PubMed 15013751) not the large scale studies (PubMed 15919996). {ECO 0000269|PubMed 15013751, ECO 0000269|PubMed 15919996}. # SUBUNIT CYDB_ECOLI Heterodimer of subunits I and II. Probably interacts with CydX, and overexpressed AppX. {ECO 0000269|PubMed 16079137, ECO 0000269|PubMed 23749980, ECO 0000269|PubMed 3281937, ECO 0000269|PubMed 6307994}. # TCDB 3.D.4.3 the proton-translocating cytochrome oxidase (cox) superfamily # TIGRFAMs TIGR00203 cydB # eggNOG COG1294 LUCA # eggNOG ENOG4105CFY Bacteria BLAST swissprot:CYDB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CYDB_ECOLI BioCyc ECOL316407:JW0723-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0723-MONOMER BioCyc EcoCyc:CYDB-MONOMER http://biocyc.org/getid?id=EcoCyc:CYDB-MONOMER BioCyc MetaCyc:CYDB-MONOMER http://biocyc.org/getid?id=MetaCyc:CYDB-MONOMER COG COG1294 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1294 DOI 10.1016/S0014-5793(04)00125-5 http://dx.doi.org/10.1016/S0014-5793(04)00125-5 DOI 10.1016/j.bbabio.2011.06.016 http://dx.doi.org/10.1016/j.bbabio.2011.06.016 DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1021/bi00357a002 http://dx.doi.org/10.1021/bi00357a002 DOI 10.1021/bi00357a003 http://dx.doi.org/10.1021/bi00357a003 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.1108217108 http://dx.doi.org/10.1073/pnas.1108217108 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00324-13 http://dx.doi.org/10.1128/JB.00324-13 DOI 10.1128/JB.00562-09 http://dx.doi.org/10.1128/JB.00562-09 EC_number EC:1.10.3.14 http://www.genome.jp/dbget-bin/www_bget?EC:1.10.3.14 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J03939 http://www.ebi.ac.uk/ena/data/view/J03939 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U30934 http://www.ebi.ac.uk/ena/data/view/U30934 ENZYME 1.10.3.14 http://enzyme.expasy.org/EC/1.10.3.14 EchoBASE EB0171 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0171 EcoGene EG10174 http://www.ecogene.org/geneInfo.php?eg_id=EG10174 EnsemblBacteria AAC73828 http://www.ensemblgenomes.org/id/AAC73828 EnsemblBacteria AAC73828 http://www.ensemblgenomes.org/id/AAC73828 EnsemblBacteria BAA35400 http://www.ensemblgenomes.org/id/BAA35400 EnsemblBacteria BAA35400 http://www.ensemblgenomes.org/id/BAA35400 EnsemblBacteria BAA35400 http://www.ensemblgenomes.org/id/BAA35400 EnsemblBacteria b0734 http://www.ensemblgenomes.org/id/b0734 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0070069 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070069 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0016682 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016682 GO_function GO:0020037 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0020037 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006119 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006119 GO_process GO:0019646 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019646 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 945347 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945347 HOGENOM HOG000084824 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000084824&db=HOGENOM6 InParanoid P0ABK2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABK2 IntAct P0ABK2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABK2* IntEnz 1.10.3.14 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.10.3.14 InterPro IPR003317 http://www.ebi.ac.uk/interpro/entry/IPR003317 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0723 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0723 KEGG_Gene eco:b0734 http://www.genome.jp/dbget-bin/www_bget?eco:b0734 KEGG_Orthology KO:K00426 http://www.genome.jp/dbget-bin/www_bget?KO:K00426 KEGG_Pathway ko00190 http://www.genome.jp/kegg-bin/show_pathway?ko00190 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA YFLPQVW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YFLPQVW PSORT swissprot:CYDB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CYDB_ECOLI PSORT-B swissprot:CYDB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CYDB_ECOLI PSORT2 swissprot:CYDB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CYDB_ECOLI Pfam PF02322 http://pfam.xfam.org/family/PF02322 Phobius swissprot:CYDB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CYDB_ECOLI PhylomeDB P0ABK2 http://phylomedb.org/?seqid=P0ABK2 ProteinModelPortal P0ABK2 http://www.proteinmodelportal.org/query/uniprot/P0ABK2 PubMed 15013751 http://www.ncbi.nlm.nih.gov/pubmed/15013751 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19542282 http://www.ncbi.nlm.nih.gov/pubmed/19542282 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 21756872 http://www.ncbi.nlm.nih.gov/pubmed/21756872 PubMed 21987791 http://www.ncbi.nlm.nih.gov/pubmed/21987791 PubMed 23749980 http://www.ncbi.nlm.nih.gov/pubmed/23749980 PubMed 2656671 http://www.ncbi.nlm.nih.gov/pubmed/2656671 PubMed 2843510 http://www.ncbi.nlm.nih.gov/pubmed/2843510 PubMed 3013298 http://www.ncbi.nlm.nih.gov/pubmed/3013298 PubMed 3013299 http://www.ncbi.nlm.nih.gov/pubmed/3013299 PubMed 3138232 http://www.ncbi.nlm.nih.gov/pubmed/3138232 PubMed 3281937 http://www.ncbi.nlm.nih.gov/pubmed/3281937 PubMed 6307994 http://www.ncbi.nlm.nih.gov/pubmed/6307994 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415262 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415262 RefSeq WP_000568275 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000568275 STRING 511145.b0734 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0734&targetmode=cogs STRING COG1294 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1294&targetmode=cogs TCDB 3.D.4.3 http://www.tcdb.org/search/result.php?tc=3.D.4.3 TIGRFAMs TIGR00203 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00203 UniProtKB CYDB_ECOLI http://www.uniprot.org/uniprot/CYDB_ECOLI UniProtKB-AC P0ABK2 http://www.uniprot.org/uniprot/P0ABK2 charge swissprot:CYDB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CYDB_ECOLI eggNOG COG1294 http://eggnogapi.embl.de/nog_data/html/tree/COG1294 eggNOG ENOG4105CFY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CFY epestfind swissprot:CYDB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CYDB_ECOLI garnier swissprot:CYDB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CYDB_ECOLI helixturnhelix swissprot:CYDB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CYDB_ECOLI hmoment swissprot:CYDB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CYDB_ECOLI iep swissprot:CYDB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CYDB_ECOLI inforesidue swissprot:CYDB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CYDB_ECOLI octanol swissprot:CYDB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CYDB_ECOLI pepcoil swissprot:CYDB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CYDB_ECOLI pepdigest swissprot:CYDB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CYDB_ECOLI pepinfo swissprot:CYDB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CYDB_ECOLI pepnet swissprot:CYDB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CYDB_ECOLI pepstats swissprot:CYDB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CYDB_ECOLI pepwheel swissprot:CYDB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CYDB_ECOLI pepwindow swissprot:CYDB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CYDB_ECOLI sigcleave swissprot:CYDB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CYDB_ECOLI ## Database ID URL or Descriptions # AltName PFLE_ECOLI Formate-C-acetyltransferase-activating enzyme 3 # AltName PFLE_ECOLI PFL-activating enzyme 3 # BioGrid 4262835 11 # CATALYTIC ACTIVITY PFLE_ECOLI S-adenosyl-L-methionine + dihydroflavodoxin + [formate C-acetyltransferase]-glycine = 5'-deoxyadenosine + L- methionine + flavodoxin semiquinone + [formate C- acetyltransferase]-glycin-2-yl radical. # COFACTOR PFLE_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000250}; Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. {ECO 0000250}; # EcoGene EG13470 ybiY # FUNCTION PFLE_ECOLI Activation of pyruvate formate-lyase 2 under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. {ECO 0000250}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0043365 [formate-C-acetyltransferase]-activating enzyme activity; IEA:UniProtKB-EC. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # IntAct P75794 5 # InterPro IPR001989 Radical_activat_CS # InterPro IPR007197 rSAM # InterPro IPR012839 Organic_radical_activase # KEGG_Brite ko01000 Enzymes # Organism PFLE_ECOLI Escherichia coli (strain K12) # PATRIC 32116851 VBIEscCol129921_0851 # PIR H64819 H64819 # PIRSF PIRSF000371 PFL_act_enz # PROSITE PS01087 RADICAL_ACTIVATING # Pfam PF04055 Radical_SAM # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PFLE_ECOLI Putative pyruvate formate-lyase 3-activating enzyme # RefSeq NP_415345 NC_000913.3 # RefSeq WP_001295295 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAA35512.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the organic radical-activating enzymes family. {ECO 0000305}. # SUBCELLULAR LOCATION PFLE_ECOLI Cytoplasm {ECO 0000250}. # TIGRFAMs TIGR02494 PFLE_PFLC # eggNOG COG1180 LUCA # eggNOG ENOG4105F1A Bacteria BLAST swissprot:PFLE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PFLE_ECOLI BioCyc ECOL316407:JW0808-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0808-MONOMER BioCyc EcoCyc:G6427-MONOMER http://biocyc.org/getid?id=EcoCyc:G6427-MONOMER COG COG1180 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1180 DIP DIP-11444N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11444N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.97.1.4 http://www.genome.jp/dbget-bin/www_bget?EC:1.97.1.4 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.97.1.4 http://enzyme.expasy.org/EC/1.97.1.4 EchoBASE EB3243 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3243 EcoGene EG13470 http://www.ecogene.org/geneInfo.php?eg_id=EG13470 EnsemblBacteria AAC73911 http://www.ensemblgenomes.org/id/AAC73911 EnsemblBacteria AAC73911 http://www.ensemblgenomes.org/id/AAC73911 EnsemblBacteria BAA35512 http://www.ensemblgenomes.org/id/BAA35512 EnsemblBacteria BAA35512 http://www.ensemblgenomes.org/id/BAA35512 EnsemblBacteria BAA35512 http://www.ensemblgenomes.org/id/BAA35512 EnsemblBacteria b0824 http://www.ensemblgenomes.org/id/b0824 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0043365 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043365 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GeneID 945445 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945445 HOGENOM HOG000011459 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000011459&db=HOGENOM6 InParanoid P75794 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75794 IntAct P75794 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75794* IntEnz 1.97.1.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.97.1.4 InterPro IPR001989 http://www.ebi.ac.uk/interpro/entry/IPR001989 InterPro IPR007197 http://www.ebi.ac.uk/interpro/entry/IPR007197 InterPro IPR012839 http://www.ebi.ac.uk/interpro/entry/IPR012839 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0808 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0808 KEGG_Gene eco:b0824 http://www.genome.jp/dbget-bin/www_bget?eco:b0824 KEGG_Orthology KO:K04069 http://www.genome.jp/dbget-bin/www_bget?KO:K04069 MINT MINT-1313356 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1313356 PROSITE PS01087 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01087 PSORT swissprot:PFLE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PFLE_ECOLI PSORT-B swissprot:PFLE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PFLE_ECOLI PSORT2 swissprot:PFLE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PFLE_ECOLI Pfam PF04055 http://pfam.xfam.org/family/PF04055 Phobius swissprot:PFLE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PFLE_ECOLI PhylomeDB P75794 http://phylomedb.org/?seqid=P75794 ProteinModelPortal P75794 http://www.proteinmodelportal.org/query/uniprot/P75794 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415345 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415345 RefSeq WP_001295295 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295295 SMR P75794 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75794 STRING 511145.b0824 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0824&targetmode=cogs STRING COG1180 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1180&targetmode=cogs TIGRFAMs TIGR02494 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02494 UniProtKB PFLE_ECOLI http://www.uniprot.org/uniprot/PFLE_ECOLI UniProtKB-AC P75794 http://www.uniprot.org/uniprot/P75794 charge swissprot:PFLE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PFLE_ECOLI eggNOG COG1180 http://eggnogapi.embl.de/nog_data/html/tree/COG1180 eggNOG ENOG4105F1A http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F1A epestfind swissprot:PFLE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PFLE_ECOLI garnier swissprot:PFLE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PFLE_ECOLI helixturnhelix swissprot:PFLE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PFLE_ECOLI hmoment swissprot:PFLE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PFLE_ECOLI iep swissprot:PFLE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PFLE_ECOLI inforesidue swissprot:PFLE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PFLE_ECOLI octanol swissprot:PFLE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PFLE_ECOLI pepcoil swissprot:PFLE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PFLE_ECOLI pepdigest swissprot:PFLE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PFLE_ECOLI pepinfo swissprot:PFLE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PFLE_ECOLI pepnet swissprot:PFLE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PFLE_ECOLI pepstats swissprot:PFLE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PFLE_ECOLI pepwheel swissprot:PFLE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PFLE_ECOLI pepwindow swissprot:PFLE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PFLE_ECOLI sigcleave swissprot:PFLE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PFLE_ECOLI ## Database ID URL or Descriptions # BioGrid 4262170 13 # EcoGene EG11722 yieE # GO_function GO:0000287 magnesium ion binding; IEA:InterPro. # GO_function GO:0008897 holo-[acyl-carrier-protein] synthase activity; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # Gene3D 3.90.470.20 -; 1. # IntAct P0ADM8 2 # InterPro IPR008278 4-PPantetheinyl_Trfase_SF # Organism YIEE_ECOLI Escherichia coli (strain K12) # PATRIC 32122919 VBIEscCol129921_3835 # PIR A65174 A65174 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIEE_ECOLI Uncharacterized protein YieE # RefSeq NP_418168 NC_000913.3 # RefSeq WP_001296581 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA62063.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAE77576.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # eggNOG COG2091 LUCA # eggNOG ENOG4105E8Q Bacteria BLAST swissprot:YIEE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIEE_ECOLI BioCyc ECOL316407:JW3690-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3690-MONOMER BioCyc EcoCyc:EG11722-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11722-MONOMER DIP DIP-36040N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36040N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1673 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1673 EcoGene EG11722 http://www.ecogene.org/geneInfo.php?eg_id=EG11722 EnsemblBacteria AAC76735 http://www.ensemblgenomes.org/id/AAC76735 EnsemblBacteria AAC76735 http://www.ensemblgenomes.org/id/AAC76735 EnsemblBacteria BAE77576 http://www.ensemblgenomes.org/id/BAE77576 EnsemblBacteria BAE77576 http://www.ensemblgenomes.org/id/BAE77576 EnsemblBacteria BAE77576 http://www.ensemblgenomes.org/id/BAE77576 EnsemblBacteria b3712 http://www.ensemblgenomes.org/id/b3712 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0008897 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008897 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.90.470.20 http://www.cathdb.info/version/latest/superfamily/3.90.470.20 GeneID 948226 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948226 HOGENOM HOG000126381 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126381&db=HOGENOM6 InParanoid P0ADM8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADM8 IntAct P0ADM8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADM8* InterPro IPR008278 http://www.ebi.ac.uk/interpro/entry/IPR008278 KEGG_Gene ecj:JW3690 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3690 KEGG_Gene eco:b3712 http://www.genome.jp/dbget-bin/www_bget?eco:b3712 PSORT swissprot:YIEE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIEE_ECOLI PSORT-B swissprot:YIEE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIEE_ECOLI PSORT2 swissprot:YIEE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIEE_ECOLI Phobius swissprot:YIEE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIEE_ECOLI ProteinModelPortal P0ADM8 http://www.proteinmodelportal.org/query/uniprot/P0ADM8 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418168 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418168 RefSeq WP_001296581 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001296581 STRING 511145.b3712 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3712&targetmode=cogs UniProtKB YIEE_ECOLI http://www.uniprot.org/uniprot/YIEE_ECOLI UniProtKB-AC P0ADM8 http://www.uniprot.org/uniprot/P0ADM8 charge swissprot:YIEE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIEE_ECOLI eggNOG COG2091 http://eggnogapi.embl.de/nog_data/html/tree/COG2091 eggNOG ENOG4105E8Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E8Q epestfind swissprot:YIEE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIEE_ECOLI garnier swissprot:YIEE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIEE_ECOLI helixturnhelix swissprot:YIEE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIEE_ECOLI hmoment swissprot:YIEE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIEE_ECOLI iep swissprot:YIEE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIEE_ECOLI inforesidue swissprot:YIEE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIEE_ECOLI octanol swissprot:YIEE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIEE_ECOLI pepcoil swissprot:YIEE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIEE_ECOLI pepdigest swissprot:YIEE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIEE_ECOLI pepinfo swissprot:YIEE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIEE_ECOLI pepnet swissprot:YIEE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIEE_ECOLI pepstats swissprot:YIEE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIEE_ECOLI pepwheel swissprot:YIEE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIEE_ECOLI pepwindow swissprot:YIEE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIEE_ECOLI sigcleave swissprot:YIEE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIEE_ECOLI ## Database ID URL or Descriptions # BioGrid 4260405 12 # CATALYTIC ACTIVITY D-erythro-1-(imidazol-4-yl)glycerol 3- phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H(2)O. {ECO:0000255|HAMAP-Rule MF_01022}. # CATALYTIC ACTIVITY L-histidinol phosphate + H(2)O = L-histidinol + phosphate. {ECO:0000255|HAMAP-Rule MF_01022}. # CDD cd07914 IGPD # COFACTOR HIS7_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_01022}; # COFACTOR HIS7_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000255|HAMAP-Rule MF_01022}; # EcoGene EG10445 hisB # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0004401 histidinol-phosphatase activity; IDA:EcoCyc. # GO_function GO:0004424 imidazoleglycerol-phosphate dehydratase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0000105 histidine biosynthetic process; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.50.1000 -; 1. # HAMAP MF_00076 HisB # HAMAP MF_01022 Bifunc_HisB # INTERACTION HIS7_ECOLI Self; NbExp=3; IntAct=EBI-1126930, EBI-1126930; P0ACA7 gstB; NbExp=4; IntAct=EBI-1126930, EBI-1120568; # IntAct P06987 5 # InterPro IPR000807 ImidazoleglycerolP_deHydtase # InterPro IPR005954 HisB_N # InterPro IPR006543 Histidinol-phos # InterPro IPR006549 HAD-SF_hydro_IIIA # InterPro IPR013954 PNK3P # InterPro IPR020565 ImidazoleglycerP_deHydtase_CS # InterPro IPR020566 His_synth_bifunc_HisB # InterPro IPR020568 Ribosomal_S5_D2-typ_fold # InterPro IPR023214 HAD-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00340 Histidine metabolism # Organism HIS7_ECOLI Escherichia coli (strain K12) # PANTHER PTHR23133:SF2 PTHR23133:SF2; 2 # PATHWAY Amino-acid biosynthesis; L-histidine biosynthesis; L- histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9. {ECO 0000255|HAMAP-Rule:MF_01022}. # PATHWAY Amino-acid biosynthesis; L-histidine biosynthesis; L- histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9. {ECO 0000255|HAMAP-Rule:MF_01022}. # PATRIC 32119379 VBIEscCol129921_2099 # PIR E64967 DWECHB # PROSITE PS00954 IGP_DEHYDRATASE_1 # PROSITE PS00955 IGP_DEHYDRATASE_2 # Pfam PF00475 IGPD # Pfam PF08645 PNK3P # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Histidine biosynthesis bifunctional protein HisB {ECO:0000255|HAMAP-Rule MF_01022} # RecName Histidine biosynthesis bifunctional protein HisB {ECO:0000255|HAMAP-Rule MF_01022} # RecName Histidinol-phosphatase {ECO:0000255|HAMAP-Rule MF_01022} # RecName Imidazoleglycerol-phosphate dehydratase {ECO:0000255|HAMAP-Rule MF_01022} # RefSeq NP_416526 NC_000913.3 # RefSeq WP_000080105 NZ_LN832404.1 # SIMILARITY In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. {ECO:0000255|HAMAP-Rule MF_01022}. # SIMILARITY In the N-terminal section; belongs to the histidinol- phosphatase family. {ECO:0000255|HAMAP-Rule MF_01022}. # SUBCELLULAR LOCATION HIS7_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_01022}. # SUPFAM SSF54211 SSF54211; 2 # SUPFAM SSF56784 SSF56784 # TIGRFAMs TIGR01261 hisB_Nterm # TIGRFAMs TIGR01656 Histidinol-ppas # TIGRFAMs TIGR01662 HAD-SF-IIIA # UniPathway UPA00031 UER00011 # UniPathway UPA00031 UER00013 # eggNOG COG0131 LUCA # eggNOG COG0241 LUCA # eggNOG ENOG4105ECC Bacteria BLAST swissprot:HIS7_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HIS7_ECOLI BioCyc ECOL316407:JW2004-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2004-MONOMER BioCyc EcoCyc:IMIDPHOSPHADEHYDHISTIDPHOSPHA-MONOMER http://biocyc.org/getid?id=EcoCyc:IMIDPHOSPHADEHYDHISTIDPHOSPHA-MONOMER BioCyc MetaCyc:IMIDPHOSPHADEHYDHISTIDPHOSPHA-MONOMER http://biocyc.org/getid?id=MetaCyc:IMIDPHOSPHADEHYDHISTIDPHOSPHA-MONOMER COG COG0131 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0131 COG COG0241 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0241 DIP DIP-9901N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9901N DOI 10.1007/BF00330514 http://dx.doi.org/10.1007/BF00330514 DOI 10.1016/0022-2836(88)90194-5 http://dx.doi.org/10.1016/0022-2836(88)90194-5 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.3.15 {ECO:0000255|HAMAP-Rule:MF_01022} http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.15 {ECO:0000255|HAMAP-Rule:MF_01022} EC_number EC:4.2.1.19 {ECO:0000255|HAMAP-Rule:MF_01022} http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.19 {ECO:0000255|HAMAP-Rule:MF_01022} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X03416 http://www.ebi.ac.uk/ena/data/view/X03416 EMBL X13462 http://www.ebi.ac.uk/ena/data/view/X13462 ENZYME 3.1.3.15 {ECO:0000255|HAMAP-Rule:MF_01022} http://enzyme.expasy.org/EC/3.1.3.15 {ECO:0000255|HAMAP-Rule:MF_01022} ENZYME 4.2.1.19 {ECO:0000255|HAMAP-Rule:MF_01022} http://enzyme.expasy.org/EC/4.2.1.19 {ECO:0000255|HAMAP-Rule:MF_01022} EchoBASE EB0440 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0440 EcoGene EG10445 http://www.ecogene.org/geneInfo.php?eg_id=EG10445 EnsemblBacteria AAC75083 http://www.ensemblgenomes.org/id/AAC75083 EnsemblBacteria AAC75083 http://www.ensemblgenomes.org/id/AAC75083 EnsemblBacteria BAA15853 http://www.ensemblgenomes.org/id/BAA15853 EnsemblBacteria BAA15853 http://www.ensemblgenomes.org/id/BAA15853 EnsemblBacteria BAA15853 http://www.ensemblgenomes.org/id/BAA15853 EnsemblBacteria b2022 http://www.ensemblgenomes.org/id/b2022 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004401 GO_function GO:0004424 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004424 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0000105 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000105 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.50.1000 http://www.cathdb.info/version/latest/superfamily/3.40.50.1000 GeneID 946552 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946552 HAMAP MF_00076 http://hamap.expasy.org/unirule/MF_00076 HAMAP MF_01022 http://hamap.expasy.org/unirule/MF_01022 HOGENOM HOG000228065 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000228065&db=HOGENOM6 InParanoid P06987 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P06987 IntAct P06987 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P06987* IntEnz 3.1.3.15 {ECO:0000255|HAMAP-Rule:MF_01022} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.15 {ECO:0000255|HAMAP-Rule:MF_01022} IntEnz 4.2.1.19 {ECO:0000255|HAMAP-Rule:MF_01022} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.19 {ECO:0000255|HAMAP-Rule:MF_01022} InterPro IPR000807 http://www.ebi.ac.uk/interpro/entry/IPR000807 InterPro IPR005954 http://www.ebi.ac.uk/interpro/entry/IPR005954 InterPro IPR006543 http://www.ebi.ac.uk/interpro/entry/IPR006543 InterPro IPR006549 http://www.ebi.ac.uk/interpro/entry/IPR006549 InterPro IPR013954 http://www.ebi.ac.uk/interpro/entry/IPR013954 InterPro IPR020565 http://www.ebi.ac.uk/interpro/entry/IPR020565 InterPro IPR020566 http://www.ebi.ac.uk/interpro/entry/IPR020566 InterPro IPR020568 http://www.ebi.ac.uk/interpro/entry/IPR020568 InterPro IPR023214 http://www.ebi.ac.uk/interpro/entry/IPR023214 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2004 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2004 KEGG_Gene eco:b2022 http://www.genome.jp/dbget-bin/www_bget?eco:b2022 KEGG_Orthology KO:K01089 http://www.genome.jp/dbget-bin/www_bget?KO:K01089 KEGG_Pathway ko00340 http://www.genome.jp/kegg-bin/show_pathway?ko00340 KEGG_Reaction rn:R03013 http://www.genome.jp/dbget-bin/www_bget?rn:R03013 KEGG_Reaction rn:R03457 http://www.genome.jp/dbget-bin/www_bget?rn:R03457 OMA PEDTFWP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PEDTFWP PANTHER PTHR23133:SF2 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23133:SF2 PROSITE PS00954 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00954 PROSITE PS00955 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00955 PSORT swissprot:HIS7_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HIS7_ECOLI PSORT-B swissprot:HIS7_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HIS7_ECOLI PSORT2 swissprot:HIS7_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HIS7_ECOLI Pfam PF00475 http://pfam.xfam.org/family/PF00475 Pfam PF08645 http://pfam.xfam.org/family/PF08645 Phobius swissprot:HIS7_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HIS7_ECOLI PhylomeDB P06987 http://phylomedb.org/?seqid=P06987 ProteinModelPortal P06987 http://www.proteinmodelportal.org/query/uniprot/P06987 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3007936 http://www.ncbi.nlm.nih.gov/pubmed/3007936 PubMed 3062174 http://www.ncbi.nlm.nih.gov/pubmed/3062174 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416526 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416526 RefSeq WP_000080105 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000080105 SMR P06987 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P06987 STRING 511145.b2022 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2022&targetmode=cogs STRING COG0131 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0131&targetmode=cogs STRING COG0241 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0241&targetmode=cogs SUPFAM SSF54211 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54211 SUPFAM SSF56784 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784 SWISS-2DPAGE P06987 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P06987 TIGRFAMs TIGR01261 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01261 TIGRFAMs TIGR01656 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01656 TIGRFAMs TIGR01662 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01662 UniProtKB HIS7_ECOLI http://www.uniprot.org/uniprot/HIS7_ECOLI UniProtKB-AC P06987 http://www.uniprot.org/uniprot/P06987 charge swissprot:HIS7_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HIS7_ECOLI eggNOG COG0131 http://eggnogapi.embl.de/nog_data/html/tree/COG0131 eggNOG COG0241 http://eggnogapi.embl.de/nog_data/html/tree/COG0241 eggNOG ENOG4105ECC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ECC epestfind swissprot:HIS7_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HIS7_ECOLI garnier swissprot:HIS7_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HIS7_ECOLI helixturnhelix swissprot:HIS7_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HIS7_ECOLI hmoment swissprot:HIS7_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HIS7_ECOLI iep swissprot:HIS7_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HIS7_ECOLI inforesidue swissprot:HIS7_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HIS7_ECOLI octanol swissprot:HIS7_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HIS7_ECOLI pepcoil swissprot:HIS7_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HIS7_ECOLI pepdigest swissprot:HIS7_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HIS7_ECOLI pepinfo swissprot:HIS7_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HIS7_ECOLI pepnet swissprot:HIS7_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HIS7_ECOLI pepstats swissprot:HIS7_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HIS7_ECOLI pepwheel swissprot:HIS7_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HIS7_ECOLI pepwindow swissprot:HIS7_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HIS7_ECOLI sigcleave swissprot:HIS7_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HIS7_ECOLI ## Database ID URL or Descriptions # BioGrid 4259130 5 # COFACTOR YNFF_ECOLI Name=Mo-bis(molybdopterin guanine dinucleotide); Xref=ChEBI CHEBI 60539; Evidence={ECO 0000250}; Note=Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit. {ECO 0000250}; # COFACTOR YNFF_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000305}; Note=Binds 1 [4Fe-4S] cluster. {ECO 0000305}; # EcoGene EG13844 ynfF # FUNCTION YNFF_ECOLI Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. {ECO 0000250}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_function GO:0009055 electron carrier activity; IEA:InterPro. # GO_function GO:0009389 dimethyl sulfoxide reductase activity; IEA:InterPro. # GO_function GO:0030151 molybdenum ion binding; IEA:InterPro. # GO_function GO:0033797 selenate reductase activity; IMP:EcoCyc. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # INTERACTION YNFF_ECOLI P69853 dmsD; NbExp=2; IntAct=EBI-6406285, EBI-4406374; # InterPro IPR006311 TAT_signal # InterPro IPR006655 Mopterin_OxRdtase_prok_CS # InterPro IPR006656 Mopterin_OxRdtase # InterPro IPR006657 MoPterin_dinucl-bd_dom # InterPro IPR006963 Mopterin_OxRdtase_4Fe-4S_dom # InterPro IPR009010 Asp_de-COase-like_dom # InterPro IPR011888 Anaer_DMSO_reductase # InterPro IPR027467 MopterinOxRdtase_cofactor_BS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko00450 Selenocompound metabolism # Organism YNFF_ECOLI Escherichia coli (strain K12) # PATRIC 32118478 VBIEscCol129921_1659 # PIR F64914 F64914 # PROSITE PS00551 MOLYBDOPTERIN_PROK_1 # PROSITE PS00932 MOLYBDOPTERIN_PROK_3 # PROSITE PS51318 TAT # PROSITE PS51669 4FE4S_MOW_BIS_MGD # PTM YNFF_ECOLI Exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven. Can also be exported by the Sec system. # Pfam PF00384 Molybdopterin # Pfam PF01568 Molydop_binding # Pfam PF04879 Molybdop_Fe4S4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNFF_ECOLI Probable dimethyl sulfoxide reductase chain YnfF # RefSeq NP_416105 NC_000913.3 # SIMILARITY Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. {ECO 0000305}. # SIMILARITY Contains 1 4Fe-4S Mo/W bis-MGD-type domain. {ECO:0000255|PROSITE-ProRule PRU01004}. # SMART SM00926 Molybdop_Fe4S4 # SUBCELLULAR LOCATION YNFF_ECOLI Cell membrane {ECO 0000250}; Peripheral membrane protein {ECO 0000250}; Cytoplasmic side {ECO 0000250}. # SUBUNIT The complex consists of three subunits: YnfF, the reductase; YnfG, an electron transfer protein, and YnfH, a membrane anchor protein. {ECO 0000305}. # SUPFAM SSF50692 SSF50692 # TCDB 5.A.3.3 the prokaryotic molybdopterin-containing oxidoreductase (pmo) family # TIGRFAMs TIGR02166 dmsA_ynfE # eggNOG COG1104 LUCA # eggNOG ENOG4105C3J Bacteria BLAST swissprot:YNFF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNFF_ECOLI BioCyc ECOL316407:JW5260-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5260-MONOMER BioCyc EcoCyc:G6846-MONOMER http://biocyc.org/getid?id=EcoCyc:G6846-MONOMER BioCyc MetaCyc:G6846-MONOMER http://biocyc.org/getid?id=MetaCyc:G6846-MONOMER COG COG0243 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0243 DIP DIP-12766N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12766N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M610507200 http://dx.doi.org/10.1074/jbc.M610507200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.8.99.- http://www.genome.jp/dbget-bin/www_bget?EC:1.8.99.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.8.99.- http://enzyme.expasy.org/EC/1.8.99.- EchoBASE EB3605 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3605 EcoGene EG13844 http://www.ecogene.org/geneInfo.php?eg_id=EG13844 EnsemblBacteria AAC74660 http://www.ensemblgenomes.org/id/AAC74660 EnsemblBacteria AAC74660 http://www.ensemblgenomes.org/id/AAC74660 EnsemblBacteria BAA15312 http://www.ensemblgenomes.org/id/BAA15312 EnsemblBacteria BAA15312 http://www.ensemblgenomes.org/id/BAA15312 EnsemblBacteria BAA15312 http://www.ensemblgenomes.org/id/BAA15312 EnsemblBacteria b1588 http://www.ensemblgenomes.org/id/b1588 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0009389 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009389 GO_function GO:0030151 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030151 GO_function GO:0033797 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033797 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GeneID 945268 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945268 HOGENOM HOG000284390 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000284390&db=HOGENOM6 InParanoid P77783 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77783 IntAct P77783 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77783* IntEnz 1.8.99 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.8.99 InterPro IPR006311 http://www.ebi.ac.uk/interpro/entry/IPR006311 InterPro IPR006655 http://www.ebi.ac.uk/interpro/entry/IPR006655 InterPro IPR006656 http://www.ebi.ac.uk/interpro/entry/IPR006656 InterPro IPR006657 http://www.ebi.ac.uk/interpro/entry/IPR006657 InterPro IPR006963 http://www.ebi.ac.uk/interpro/entry/IPR006963 InterPro IPR009010 http://www.ebi.ac.uk/interpro/entry/IPR009010 InterPro IPR011888 http://www.ebi.ac.uk/interpro/entry/IPR011888 InterPro IPR027467 http://www.ebi.ac.uk/interpro/entry/IPR027467 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5260 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5260 KEGG_Gene eco:b1588 http://www.genome.jp/dbget-bin/www_bget?eco:b1588 KEGG_Orthology KO:K07310 http://www.genome.jp/dbget-bin/www_bget?KO:K07310 KEGG_Pathway ko00450 http://www.genome.jp/kegg-bin/show_pathway?ko00450 OMA INHTNEV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=INHTNEV PROSITE PS00551 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00551 PROSITE PS00932 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00932 PROSITE PS51318 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51318 PROSITE PS51669 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51669 PSORT swissprot:YNFF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNFF_ECOLI PSORT-B swissprot:YNFF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNFF_ECOLI PSORT2 swissprot:YNFF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNFF_ECOLI Pfam PF00384 http://pfam.xfam.org/family/PF00384 Pfam PF01568 http://pfam.xfam.org/family/PF01568 Pfam PF04879 http://pfam.xfam.org/family/PF04879 Phobius swissprot:YNFF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNFF_ECOLI PhylomeDB P77783 http://phylomedb.org/?seqid=P77783 ProteinModelPortal P77783 http://www.proteinmodelportal.org/query/uniprot/P77783 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17218314 http://www.ncbi.nlm.nih.gov/pubmed/17218314 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416105 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416105 SMART SM00926 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00926 SMR P77783 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77783 STRING 511145.b1588 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1588&targetmode=cogs STRING COG0243 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0243&targetmode=cogs SUPFAM SSF50692 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50692 TCDB 5.A.3.3 http://www.tcdb.org/search/result.php?tc=5.A.3.3 TIGRFAMs TIGR02166 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02166 UniProtKB YNFF_ECOLI http://www.uniprot.org/uniprot/YNFF_ECOLI UniProtKB-AC P77783 http://www.uniprot.org/uniprot/P77783 charge swissprot:YNFF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNFF_ECOLI eggNOG COG1104 http://eggnogapi.embl.de/nog_data/html/tree/COG1104 eggNOG ENOG4105C3J http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C3J epestfind swissprot:YNFF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNFF_ECOLI garnier swissprot:YNFF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNFF_ECOLI helixturnhelix swissprot:YNFF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNFF_ECOLI hmoment swissprot:YNFF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNFF_ECOLI iep swissprot:YNFF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNFF_ECOLI inforesidue swissprot:YNFF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNFF_ECOLI octanol swissprot:YNFF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNFF_ECOLI pepcoil swissprot:YNFF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNFF_ECOLI pepdigest swissprot:YNFF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNFF_ECOLI pepinfo swissprot:YNFF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNFF_ECOLI pepnet swissprot:YNFF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNFF_ECOLI pepstats swissprot:YNFF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNFF_ECOLI pepwheel swissprot:YNFF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNFF_ECOLI pepwindow swissprot:YNFF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNFF_ECOLI sigcleave swissprot:YNFF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNFF_ECOLI ## Database ID URL or Descriptions # BioGrid 4263097 3 # EcoGene EG14283 ykfF # InterPro IPR009253 DUF905 # Organism YKFF_ECOLI Escherichia coli (strain K12) # PATRIC 32115615 VBIEscCol129921_0251 # PDB 2HJJ NMR; -; A=1-79 # PIR A64750 A64750 # Pfam PF06006 DUF905 # ProDom PD028015 DUF905_proteobac # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YKFF_ECOLI UPF0401 protein YkfF # RefSeq NP_414783 NC_000913.3 # RefSeq WP_000194654 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0401 family. {ECO 0000305}. # eggNOG ENOG4106ZN7 Bacteria # eggNOG ENOG410YVYF LUCA BLAST swissprot:YKFF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YKFF_ECOLI BioCyc ECOL316407:JW5023-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5023-MONOMER BioCyc EcoCyc:G6124-MONOMER http://biocyc.org/getid?id=EcoCyc:G6124-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4031 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4031 EcoGene EG14283 http://www.ecogene.org/geneInfo.php?eg_id=EG14283 EnsemblBacteria AAC73352 http://www.ensemblgenomes.org/id/AAC73352 EnsemblBacteria AAC73352 http://www.ensemblgenomes.org/id/AAC73352 EnsemblBacteria BAA77918 http://www.ensemblgenomes.org/id/BAA77918 EnsemblBacteria BAA77918 http://www.ensemblgenomes.org/id/BAA77918 EnsemblBacteria BAA77918 http://www.ensemblgenomes.org/id/BAA77918 EnsemblBacteria b0249 http://www.ensemblgenomes.org/id/b0249 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 948839 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948839 HOGENOM HOG000266874 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000266874&db=HOGENOM6 InterPro IPR009253 http://www.ebi.ac.uk/interpro/entry/IPR009253 KEGG_Gene ecj:JW5023 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5023 KEGG_Gene eco:b0249 http://www.genome.jp/dbget-bin/www_bget?eco:b0249 OMA YINIAIE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YINIAIE PDB 2HJJ http://www.ebi.ac.uk/pdbe-srv/view/entry/2HJJ PDBsum 2HJJ http://www.ebi.ac.uk/pdbsum/2HJJ PSORT swissprot:YKFF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YKFF_ECOLI PSORT-B swissprot:YKFF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YKFF_ECOLI PSORT2 swissprot:YKFF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YKFF_ECOLI Pfam PF06006 http://pfam.xfam.org/family/PF06006 Phobius swissprot:YKFF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YKFF_ECOLI PhylomeDB P75677 http://phylomedb.org/?seqid=P75677 ProteinModelPortal P75677 http://www.proteinmodelportal.org/query/uniprot/P75677 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414783 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414783 RefSeq WP_000194654 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000194654 SMR P75677 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75677 STRING 511145.b0249 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0249&targetmode=cogs UniProtKB YKFF_ECOLI http://www.uniprot.org/uniprot/YKFF_ECOLI UniProtKB-AC P75677 http://www.uniprot.org/uniprot/P75677 charge swissprot:YKFF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YKFF_ECOLI eggNOG ENOG4106ZN7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106ZN7 eggNOG ENOG410YVYF http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YVYF epestfind swissprot:YKFF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YKFF_ECOLI garnier swissprot:YKFF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YKFF_ECOLI helixturnhelix swissprot:YKFF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YKFF_ECOLI hmoment swissprot:YKFF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YKFF_ECOLI iep swissprot:YKFF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YKFF_ECOLI inforesidue swissprot:YKFF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YKFF_ECOLI octanol swissprot:YKFF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YKFF_ECOLI pepcoil swissprot:YKFF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YKFF_ECOLI pepdigest swissprot:YKFF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YKFF_ECOLI pepinfo swissprot:YKFF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YKFF_ECOLI pepnet swissprot:YKFF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YKFF_ECOLI pepstats swissprot:YKFF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YKFF_ECOLI pepwheel swissprot:YKFF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YKFF_ECOLI pepwindow swissprot:YKFF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YKFF_ECOLI sigcleave swissprot:YKFF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YKFF_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES DDPX_ECOLI Kinetic parameters KM=1.4 mM for D-Ala-D-Ala {ECO 0000269|PubMed 9751644}; KM=550 mM for L-Ala-D-Ala {ECO 0000269|PubMed 9751644}; Note=Kcat is 170 sec(-1) with D-Ala-D-Ala. Kcat is 70 sec(-1) with L-Ala-D-Ala.; # BioGrid 4259362 255 # CATALYTIC ACTIVITY DDPX_ECOLI D-Ala-D-Ala + H(2)O = 2 D-Ala. {ECO 0000255|HAMAP-Rule MF_01924, ECO 0000269|PubMed 9751644}. # COFACTOR DDPX_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000305|PubMed 9751644}; Note=Binds 1 zinc ion per subunit. {ECO 0000305|PubMed 9751644}; # EcoGene EG13791 ddpX # FUNCTION DDPX_ECOLI Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide. May have a role in cell-wall turnover. {ECO 0000255|HAMAP-Rule MF_01924, ECO 0000269|PubMed 9751644}. # GO_component GO:0005618 cell wall; IEA:InterPro. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0008270 zinc ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0009046 zinc D-Ala-D-Ala carboxypeptidase activity; IDA:EcoCyc. # GO_function GO:0016805 dipeptidase activity; IEA:UniProtKB-HAMAP. # GO_process GO:0009252 peptidoglycan biosynthetic process; TAS:EcoCyc. # GO_process GO:0042594 response to starvation; TAS:EcoCyc. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005618 cell wall # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 3.30.1380.10 -; 1. # HAMAP MF_01924 A_A_dipeptidase # InterPro IPR000755 A_A_dipeptidase # InterPro IPR009045 Hedgehog_sig/DD-Pept_Zn-bd_dom # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # Organism DDPX_ECOLI Escherichia coli (strain K12) # PATRIC 32118270 VBIEscCol129921_1555 # PIR C64902 C64902 # PIRSF PIRSF026671 AA_dipeptidase # Pfam PF01427 Peptidase_M15 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName D-alanyl-D-alanine dipeptidase {ECO:0000255|HAMAP-Rule MF_01924} # RefSeq NP_416005 NC_000913.3 # RefSeq WP_001285833 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase M15D family. {ECO:0000255|HAMAP-Rule MF_01924}. # SUBCELLULAR LOCATION DDPX_ECOLI Cytoplasm {ECO 0000305|PubMed 9751644}. # SUPFAM SSF55166 SSF55166 # eggNOG COG2173 LUCA # eggNOG ENOG4108UQS Bacteria BLAST swissprot:DDPX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DDPX_ECOLI BioCyc ECOL316407:JW1483-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1483-MONOMER BioCyc EcoCyc:G6782-MONOMER http://biocyc.org/getid?id=EcoCyc:G6782-MONOMER BioCyc MetaCyc:G6782-MONOMER http://biocyc.org/getid?id=MetaCyc:G6782-MONOMER COG COG2173 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2173 DIP DIP-9418N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9418N DOI 10.1016/S1074-5521(98)90005-9 http://dx.doi.org/10.1016/S1074-5521(98)90005-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.13.22 {ECO:0000255|HAMAP-Rule:MF_01924} http://www.genome.jp/dbget-bin/www_bget?EC:3.4.13.22 {ECO:0000255|HAMAP-Rule:MF_01924} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.4.13.22 {ECO:0000255|HAMAP-Rule:MF_01924} http://enzyme.expasy.org/EC/3.4.13.22 {ECO:0000255|HAMAP-Rule:MF_01924} EchoBASE EB3552 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3552 EcoGene EG13791 http://www.ecogene.org/geneInfo.php?eg_id=EG13791 EnsemblBacteria AAC74561 http://www.ensemblgenomes.org/id/AAC74561 EnsemblBacteria AAC74561 http://www.ensemblgenomes.org/id/AAC74561 EnsemblBacteria BAA15143 http://www.ensemblgenomes.org/id/BAA15143 EnsemblBacteria BAA15143 http://www.ensemblgenomes.org/id/BAA15143 EnsemblBacteria BAA15143 http://www.ensemblgenomes.org/id/BAA15143 EnsemblBacteria b1488 http://www.ensemblgenomes.org/id/b1488 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005618 GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0009046 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009046 GO_function GO:0016805 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016805 GO_process GO:0009252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009252 GO_process GO:0042594 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042594 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005618 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 3.30.1380.10 http://www.cathdb.info/version/latest/superfamily/3.30.1380.10 GeneID 945532 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945532 HAMAP MF_01924 http://hamap.expasy.org/unirule/MF_01924 HOGENOM HOG000200848 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000200848&db=HOGENOM6 InParanoid P77790 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77790 IntEnz 3.4.13.22 {ECO:0000255|HAMAP-Rule:MF_01924} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.13.22 {ECO:0000255|HAMAP-Rule:MF_01924} InterPro IPR000755 http://www.ebi.ac.uk/interpro/entry/IPR000755 InterPro IPR009045 http://www.ebi.ac.uk/interpro/entry/IPR009045 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW1483 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1483 KEGG_Gene eco:b1488 http://www.genome.jp/dbget-bin/www_bget?eco:b1488 KEGG_Orthology KO:K08641 http://www.genome.jp/dbget-bin/www_bget?KO:K08641 OMA CYRPVRS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CYRPVRS PSORT swissprot:DDPX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DDPX_ECOLI PSORT-B swissprot:DDPX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DDPX_ECOLI PSORT2 swissprot:DDPX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DDPX_ECOLI Pfam PF01427 http://pfam.xfam.org/family/PF01427 Phobius swissprot:DDPX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DDPX_ECOLI PhylomeDB P77790 http://phylomedb.org/?seqid=P77790 ProteinModelPortal P77790 http://www.proteinmodelportal.org/query/uniprot/P77790 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9751644 http://www.ncbi.nlm.nih.gov/pubmed/9751644 RefSeq NP_416005 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416005 RefSeq WP_001285833 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001285833 SMR P77790 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77790 STRING 511145.b1488 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1488&targetmode=cogs STRING COG2173 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2173&targetmode=cogs SUPFAM SSF55166 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55166 UniProtKB DDPX_ECOLI http://www.uniprot.org/uniprot/DDPX_ECOLI UniProtKB-AC P77790 http://www.uniprot.org/uniprot/P77790 charge swissprot:DDPX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DDPX_ECOLI eggNOG COG2173 http://eggnogapi.embl.de/nog_data/html/tree/COG2173 eggNOG ENOG4108UQS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UQS epestfind swissprot:DDPX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DDPX_ECOLI garnier swissprot:DDPX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DDPX_ECOLI helixturnhelix swissprot:DDPX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DDPX_ECOLI hmoment swissprot:DDPX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DDPX_ECOLI iep swissprot:DDPX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DDPX_ECOLI inforesidue swissprot:DDPX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DDPX_ECOLI octanol swissprot:DDPX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DDPX_ECOLI pepcoil swissprot:DDPX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DDPX_ECOLI pepdigest swissprot:DDPX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DDPX_ECOLI pepinfo swissprot:DDPX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DDPX_ECOLI pepnet swissprot:DDPX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DDPX_ECOLI pepstats swissprot:DDPX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DDPX_ECOLI pepwheel swissprot:DDPX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DDPX_ECOLI pepwindow swissprot:DDPX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DDPX_ECOLI sigcleave swissprot:DDPX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DDPX_ECOLI ## Database ID URL or Descriptions # BioGrid 4263447 6 # EcoGene EG11874 yiiQ # IntAct P32160 5 # InterPro IPR009918 DUF1454 # Organism YIIQ_ECOLI Escherichia coli (strain K12) # PATRIC 32123353 VBIEscCol129921_4037 # PIR S40863 S40863 # Pfam PF07305 DUF1454 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIIQ_ECOLI Uncharacterized protein YiiQ # RefSeq NP_418355 NC_000913.3 # RefSeq WP_000802216 NZ_LN832404.1 # eggNOG ENOG4105EBK Bacteria # eggNOG ENOG410ZPNJ LUCA BLAST swissprot:YIIQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIIQ_ECOLI BioCyc ECOL316407:JW3891-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3891-MONOMER BioCyc EcoCyc:EG11874-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11874-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1820 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1820 EcoGene EG11874 http://www.ecogene.org/geneInfo.php?eg_id=EG11874 EnsemblBacteria AAC76902 http://www.ensemblgenomes.org/id/AAC76902 EnsemblBacteria AAC76902 http://www.ensemblgenomes.org/id/AAC76902 EnsemblBacteria BAE77390 http://www.ensemblgenomes.org/id/BAE77390 EnsemblBacteria BAE77390 http://www.ensemblgenomes.org/id/BAE77390 EnsemblBacteria BAE77390 http://www.ensemblgenomes.org/id/BAE77390 EnsemblBacteria b3920 http://www.ensemblgenomes.org/id/b3920 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 948408 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948408 HOGENOM HOG000126673 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126673&db=HOGENOM6 IntAct P32160 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32160* InterPro IPR009918 http://www.ebi.ac.uk/interpro/entry/IPR009918 KEGG_Gene ecj:JW3891 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3891 KEGG_Gene eco:b3920 http://www.genome.jp/dbget-bin/www_bget?eco:b3920 OMA FMPSLTN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FMPSLTN PSORT swissprot:YIIQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIIQ_ECOLI PSORT-B swissprot:YIIQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIIQ_ECOLI PSORT2 swissprot:YIIQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIIQ_ECOLI Pfam PF07305 http://pfam.xfam.org/family/PF07305 Phobius swissprot:YIIQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIIQ_ECOLI ProteinModelPortal P32160 http://www.proteinmodelportal.org/query/uniprot/P32160 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418355 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418355 RefSeq WP_000802216 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000802216 STRING 511145.b3920 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3920&targetmode=cogs UniProtKB YIIQ_ECOLI http://www.uniprot.org/uniprot/YIIQ_ECOLI UniProtKB-AC P32160 http://www.uniprot.org/uniprot/P32160 charge swissprot:YIIQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIIQ_ECOLI eggNOG ENOG4105EBK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EBK eggNOG ENOG410ZPNJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZPNJ epestfind swissprot:YIIQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIIQ_ECOLI garnier swissprot:YIIQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIIQ_ECOLI helixturnhelix swissprot:YIIQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIIQ_ECOLI hmoment swissprot:YIIQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIIQ_ECOLI iep swissprot:YIIQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIIQ_ECOLI inforesidue swissprot:YIIQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIIQ_ECOLI octanol swissprot:YIIQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIIQ_ECOLI pepcoil swissprot:YIIQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIIQ_ECOLI pepdigest swissprot:YIIQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIIQ_ECOLI pepinfo swissprot:YIIQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIIQ_ECOLI pepnet swissprot:YIIQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIIQ_ECOLI pepstats swissprot:YIIQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIIQ_ECOLI pepwheel swissprot:YIIQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIIQ_ECOLI pepwindow swissprot:YIIQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIIQ_ECOLI sigcleave swissprot:YIIQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIIQ_ECOLI ## Database ID URL or Descriptions # AltName AMY2_ECOLI 1,4-alpha-D-glucan glucanohydrolase # BioGrid 4260380 7 # CATALYTIC ACTIVITY Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha- linked D-glucose units. {ECO:0000269|PubMed 1400215}. # CAZy GH13 Glycoside Hydrolase Family 13 # COFACTOR AMY2_ECOLI Name=Ca(2+); Xref=ChEBI CHEBI 29108; Evidence={ECO 0000250|UniProtKB P06278}; Note=Binds 1 Ca(2+) ion per subunit. {ECO 0000250|UniProtKB P06278}; # EcoGene EG11387 amyA # GO_component GO:0005737 cytoplasm; IDA:EcoCyc. # GO_function GO:0004556 alpha-amylase activity; IDA:EcoCyc. # GO_function GO:0005509 calcium ion binding; IEA:InterPro. # GO_process GO:0005975 carbohydrate metabolic process; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # Gene3D 2.60.40.1180 -; 1. # Gene3D 3.20.20.80 -; 1. # IntAct P26612 4 # InterPro IPR006047 Glyco_hydro_13_cat_dom # InterPro IPR006048 A-amylase/branching_C # InterPro IPR013776 A-amylase_thermo # InterPro IPR013780 Glyco_hydro_b # InterPro IPR013781 Glyco_hydro_catalytic_dom # InterPro IPR015902 Glyco_hydro_13 # InterPro IPR017853 Glycoside_hydrolase_SF # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00500 Starch and sucrose metabolism # KEGG_Pathway ko04973 Carbohydrate digestion and absorption # Organism AMY2_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10357 PTHR10357; 2 # PATRIC 32119189 VBIEscCol129921_2009 # PIR D64956 A45738 # PIRSF PIRSF001021 Alph-amls_thrmst # Pfam PF00128 Alpha-amylase # Pfam PF02806 Alpha-amylase_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AMY2_ECOLI Cytoplasmic alpha-amylase # RefSeq NP_416437 NC_000913.3 # RefSeq WP_001245695 NZ_LN832404.1 # SIMILARITY Belongs to the glycosyl hydrolase 13 family. {ECO 0000305}. # SMART SM00642 Aamy # SUBCELLULAR LOCATION AMY2_ECOLI Cytoplasm {ECO 0000269|PubMed 1400215}. # SUBUNIT Monomer. {ECO 0000250}. # SUPFAM SSF51445 SSF51445 # eggNOG COG0366 LUCA # eggNOG ENOG4105E5K Bacteria BLAST swissprot:AMY2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AMY2_ECOLI BioCyc ECOL316407:JW1912-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1912-MONOMER BioCyc EcoCyc:ALPHA-AMYL-CYTO-MONOMER http://biocyc.org/getid?id=EcoCyc:ALPHA-AMYL-CYTO-MONOMER BioCyc MetaCyc:ALPHA-AMYL-CYTO-MONOMER http://biocyc.org/getid?id=MetaCyc:ALPHA-AMYL-CYTO-MONOMER COG COG0366 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0366 DIP DIP-9108N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9108N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1099/00221287-138-6-1051 http://dx.doi.org/10.1099/00221287-138-6-1051 DOI 10.1099/00221287-139-7-1401 http://dx.doi.org/10.1099/00221287-139-7-1401 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.2.1.1 {ECO:0000269|PubMed:1400215} http://www.genome.jp/dbget-bin/www_bget?EC:3.2.1.1 {ECO:0000269|PubMed:1400215} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L01642 http://www.ebi.ac.uk/ena/data/view/L01642 EMBL L13279 http://www.ebi.ac.uk/ena/data/view/L13279 EMBL M85240 http://www.ebi.ac.uk/ena/data/view/M85240 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.2.1.1 {ECO:0000269|PubMed:1400215} http://enzyme.expasy.org/EC/3.2.1.1 {ECO:0000269|PubMed:1400215} EchoBASE EB1360 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1360 EcoGene EG11387 http://www.ecogene.org/geneInfo.php?eg_id=EG11387 EnsemblBacteria AAC74994 http://www.ensemblgenomes.org/id/AAC74994 EnsemblBacteria AAC74994 http://www.ensemblgenomes.org/id/AAC74994 EnsemblBacteria BAA15755 http://www.ensemblgenomes.org/id/BAA15755 EnsemblBacteria BAA15755 http://www.ensemblgenomes.org/id/BAA15755 EnsemblBacteria BAA15755 http://www.ensemblgenomes.org/id/BAA15755 EnsemblBacteria b1927 http://www.ensemblgenomes.org/id/b1927 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004556 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004556 GO_function GO:0005509 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 Gene3D 2.60.40.1180 http://www.cathdb.info/version/latest/superfamily/2.60.40.1180 Gene3D 3.20.20.80 http://www.cathdb.info/version/latest/superfamily/3.20.20.80 GeneID 946434 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946434 HOGENOM HOG000094847 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000094847&db=HOGENOM6 InParanoid P26612 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P26612 IntAct P26612 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P26612* IntEnz 3.2.1.1 {ECO:0000269|PubMed:1400215} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.2.1.1 {ECO:0000269|PubMed:1400215} InterPro IPR006047 http://www.ebi.ac.uk/interpro/entry/IPR006047 InterPro IPR006048 http://www.ebi.ac.uk/interpro/entry/IPR006048 InterPro IPR013776 http://www.ebi.ac.uk/interpro/entry/IPR013776 InterPro IPR013780 http://www.ebi.ac.uk/interpro/entry/IPR013780 InterPro IPR013781 http://www.ebi.ac.uk/interpro/entry/IPR013781 InterPro IPR015902 http://www.ebi.ac.uk/interpro/entry/IPR015902 InterPro IPR017853 http://www.ebi.ac.uk/interpro/entry/IPR017853 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1912 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1912 KEGG_Gene eco:b1927 http://www.genome.jp/dbget-bin/www_bget?eco:b1927 KEGG_Orthology KO:K01176 http://www.genome.jp/dbget-bin/www_bget?KO:K01176 KEGG_Pathway ko00500 http://www.genome.jp/kegg-bin/show_pathway?ko00500 KEGG_Pathway ko04973 http://www.genome.jp/kegg-bin/show_pathway?ko04973 KEGG_Reaction rn:R02108 http://www.genome.jp/dbget-bin/www_bget?rn:R02108 MINT MINT-1279253 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1279253 OMA FFHWYYP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FFHWYYP PANTHER PTHR10357 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10357 PSORT swissprot:AMY2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AMY2_ECOLI PSORT-B swissprot:AMY2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AMY2_ECOLI PSORT2 swissprot:AMY2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AMY2_ECOLI Pfam PF00128 http://pfam.xfam.org/family/PF00128 Pfam PF02806 http://pfam.xfam.org/family/PF02806 Phobius swissprot:AMY2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AMY2_ECOLI PhylomeDB P26612 http://phylomedb.org/?seqid=P26612 ProteinModelPortal P26612 http://www.proteinmodelportal.org/query/uniprot/P26612 PubMed 1400215 http://www.ncbi.nlm.nih.gov/pubmed/1400215 PubMed 1527488 http://www.ncbi.nlm.nih.gov/pubmed/1527488 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8371104 http://www.ncbi.nlm.nih.gov/pubmed/8371104 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416437 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416437 RefSeq WP_001245695 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001245695 SMART SM00642 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00642 SMR P26612 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P26612 STRING 511145.b1927 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1927&targetmode=cogs STRING COG0366 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0366&targetmode=cogs SUPFAM SSF51445 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51445 UniProtKB AMY2_ECOLI http://www.uniprot.org/uniprot/AMY2_ECOLI UniProtKB-AC P26612 http://www.uniprot.org/uniprot/P26612 charge swissprot:AMY2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AMY2_ECOLI eggNOG COG0366 http://eggnogapi.embl.de/nog_data/html/tree/COG0366 eggNOG ENOG4105E5K http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E5K epestfind swissprot:AMY2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AMY2_ECOLI garnier swissprot:AMY2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AMY2_ECOLI helixturnhelix swissprot:AMY2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AMY2_ECOLI hmoment swissprot:AMY2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AMY2_ECOLI iep swissprot:AMY2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AMY2_ECOLI inforesidue swissprot:AMY2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AMY2_ECOLI octanol swissprot:AMY2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AMY2_ECOLI pepcoil swissprot:AMY2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AMY2_ECOLI pepdigest swissprot:AMY2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AMY2_ECOLI pepinfo swissprot:AMY2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AMY2_ECOLI pepnet swissprot:AMY2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AMY2_ECOLI pepstats swissprot:AMY2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AMY2_ECOLI pepwheel swissprot:AMY2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AMY2_ECOLI pepwindow swissprot:AMY2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AMY2_ECOLI sigcleave swissprot:AMY2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AMY2_ECOLI ## Database ID URL or Descriptions # BioGrid 4260436 27 # DISRUPTION PHENOTYPE Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain. {ECO:0000269|PubMed 20345943}. # EcoGene EG11989 yehC # FUNCTION YEHC_ECOLI Part of the yehABCD fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. {ECO 0000269|PubMed 20345943}. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IEA:InterPro. # GO_process GO:0043711 pilus organization; IEA:InterPro. # GO_process GO:0061077 chaperone-mediated protein folding; IEA:InterPro. # GO_process GO:0071555 cell wall organization; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0006457 protein folding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 2.60.40.1070 -; 1. # Gene3D 2.60.40.360 -; 1. # INDUCTION Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression. {ECO:0000269|PubMed 20345943}. # IntAct P33342 3 # InterPro IPR001829 Pili_assmbl_chaperone_bac # InterPro IPR008962 PapD-like # InterPro IPR016147 Pili_assmbl_chaperone_N # InterPro IPR016148 Pili_assmbl_chaperone_C # InterPro IPR018046 Pili_assmbl_chaperone_CS # MISCELLANEOUS The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed. {ECO:0000305|PubMed 20345943}. # Organism YEHC_ECOLI Escherichia coli (strain K12) # PATRIC 32119553 VBIEscCol129921_2187 # PIR E64978 E64978 # PRINTS PR00969 CHAPERONPILI # PROSITE PS00635 PILI_CHAPERONE # Pfam PF00345 PapD_N # Pfam PF02753 PapD_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEHC_ECOLI Probable fimbrial chaperone YehC # RefSeq NP_416613 NC_000913.3 # SIMILARITY Belongs to the periplasmic pilus chaperone family. {ECO 0000305}. # SIMILARITY Contains 1 Ig-like (immunoglobulin-like) domain. {ECO 0000305}. # SUBCELLULAR LOCATION YEHC_ECOLI Periplasm {ECO 0000250}. # SUPFAM SSF49354 SSF49354 # SUPFAM SSF49584 SSF49584 # eggNOG COG3121 LUCA # eggNOG ENOG4108MQF Bacteria BLAST swissprot:YEHC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEHC_ECOLI BioCyc ECOL316407:JW2097-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2097-MONOMER BioCyc EcoCyc:EG11989-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11989-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1462-2920.2010.02202.x http://dx.doi.org/10.1111/j.1462-2920.2010.02202.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1932 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1932 EcoGene EG11989 http://www.ecogene.org/geneInfo.php?eg_id=EG11989 EnsemblBacteria AAC75171 http://www.ensemblgenomes.org/id/AAC75171 EnsemblBacteria AAC75171 http://www.ensemblgenomes.org/id/AAC75171 EnsemblBacteria BAE76588 http://www.ensemblgenomes.org/id/BAE76588 EnsemblBacteria BAE76588 http://www.ensemblgenomes.org/id/BAE76588 EnsemblBacteria BAE76588 http://www.ensemblgenomes.org/id/BAE76588 EnsemblBacteria b2110 http://www.ensemblgenomes.org/id/b2110 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_process GO:0043711 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043711 GO_process GO:0061077 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061077 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 2.60.40.1070 http://www.cathdb.info/version/latest/superfamily/2.60.40.1070 Gene3D 2.60.40.360 http://www.cathdb.info/version/latest/superfamily/2.60.40.360 GeneID 946621 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946621 HOGENOM HOG000260152 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260152&db=HOGENOM6 IntAct P33342 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33342* InterPro IPR001829 http://www.ebi.ac.uk/interpro/entry/IPR001829 InterPro IPR008962 http://www.ebi.ac.uk/interpro/entry/IPR008962 InterPro IPR016147 http://www.ebi.ac.uk/interpro/entry/IPR016147 InterPro IPR016148 http://www.ebi.ac.uk/interpro/entry/IPR016148 InterPro IPR018046 http://www.ebi.ac.uk/interpro/entry/IPR018046 KEGG_Gene ecj:JW2097 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2097 KEGG_Gene eco:b2110 http://www.genome.jp/dbget-bin/www_bget?eco:b2110 OMA TIMIAPQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TIMIAPQ PRINTS PR00969 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00969 PROSITE PS00635 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00635 PSORT swissprot:YEHC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEHC_ECOLI PSORT-B swissprot:YEHC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEHC_ECOLI PSORT2 swissprot:YEHC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEHC_ECOLI Pfam PF00345 http://pfam.xfam.org/family/PF00345 Pfam PF02753 http://pfam.xfam.org/family/PF02753 Phobius swissprot:YEHC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEHC_ECOLI PhylomeDB P33342 http://phylomedb.org/?seqid=P33342 ProteinModelPortal P33342 http://www.proteinmodelportal.org/query/uniprot/P33342 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20345943 http://www.ncbi.nlm.nih.gov/pubmed/20345943 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416613 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416613 SMR P33342 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33342 STRING 511145.b2110 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2110&targetmode=cogs SUPFAM SSF49354 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49354 SUPFAM SSF49584 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49584 UniProtKB YEHC_ECOLI http://www.uniprot.org/uniprot/YEHC_ECOLI UniProtKB-AC P33342 http://www.uniprot.org/uniprot/P33342 charge swissprot:YEHC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEHC_ECOLI eggNOG COG3121 http://eggnogapi.embl.de/nog_data/html/tree/COG3121 eggNOG ENOG4108MQF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MQF epestfind swissprot:YEHC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEHC_ECOLI garnier swissprot:YEHC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEHC_ECOLI helixturnhelix swissprot:YEHC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEHC_ECOLI hmoment swissprot:YEHC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEHC_ECOLI iep swissprot:YEHC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEHC_ECOLI inforesidue swissprot:YEHC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEHC_ECOLI octanol swissprot:YEHC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEHC_ECOLI pepcoil swissprot:YEHC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEHC_ECOLI pepdigest swissprot:YEHC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEHC_ECOLI pepinfo swissprot:YEHC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEHC_ECOLI pepnet swissprot:YEHC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEHC_ECOLI pepstats swissprot:YEHC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEHC_ECOLI pepwheel swissprot:YEHC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEHC_ECOLI pepwindow swissprot:YEHC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEHC_ECOLI sigcleave swissprot:YEHC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEHC_ECOLI ## Database ID URL or Descriptions # BioGrid 4260743 157 # CDD cd06174 MFS # EcoGene EG13126 ygcS # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IBA:GO_Central. # GO_function GO:0022891 substrate-specific transmembrane transporter activity; IBA:GO_Central. # GO_process GO:0015850 organic hydroxy compound transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR005828 MFS_sugar_transport-like # InterPro IPR005829 Sugar_transporter_CS # InterPro IPR020846 MFS_dom # Organism YGCS_ECOLI Escherichia coli (strain K12) # PATRIC 32120954 VBIEscCol129921_2869 # PIR G65058 G65058 # PROSITE PS00217 SUGAR_TRANSPORT_2 # PROSITE PS50850 MFS # Pfam PF00083 Sugar_tr # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGCS_ECOLI Inner membrane metabolite transport protein YgcS # RefSeq NP_417251 NC_000913.3 # RefSeq WP_001098105 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA69281.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. {ECO 0000305}. # SUBCELLULAR LOCATION YGCS_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.1.95 the major facilitator superfamily (mfs) # eggNOG ENOG4105C54 Bacteria # eggNOG ENOG410XQKC LUCA BLAST swissprot:YGCS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGCS_ECOLI BioCyc ECOL316407:JW5845-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5845-MONOMER BioCyc EcoCyc:B2771-MONOMER http://biocyc.org/getid?id=EcoCyc:B2771-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EchoBASE EB2927 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2927 EcoGene EG13126 http://www.ecogene.org/geneInfo.php?eg_id=EG13126 EnsemblBacteria AAC75813 http://www.ensemblgenomes.org/id/AAC75813 EnsemblBacteria AAC75813 http://www.ensemblgenomes.org/id/AAC75813 EnsemblBacteria BAE76848 http://www.ensemblgenomes.org/id/BAE76848 EnsemblBacteria BAE76848 http://www.ensemblgenomes.org/id/BAE76848 EnsemblBacteria BAE76848 http://www.ensemblgenomes.org/id/BAE76848 EnsemblBacteria b2771 http://www.ensemblgenomes.org/id/b2771 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0022891 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022891 GO_process GO:0015850 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015850 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 947238 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947238 HOGENOM HOG000077075 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000077075&db=HOGENOM6 InParanoid Q46909 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46909 InterPro IPR005828 http://www.ebi.ac.uk/interpro/entry/IPR005828 InterPro IPR005829 http://www.ebi.ac.uk/interpro/entry/IPR005829 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Gene ecj:JW5845 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5845 KEGG_Gene eco:b2771 http://www.genome.jp/dbget-bin/www_bget?eco:b2771 OMA TRNIRMI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TRNIRMI PROSITE PS00217 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00217 PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:YGCS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGCS_ECOLI PSORT-B swissprot:YGCS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGCS_ECOLI PSORT2 swissprot:YGCS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGCS_ECOLI Pfam PF00083 http://pfam.xfam.org/family/PF00083 Phobius swissprot:YGCS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGCS_ECOLI PhylomeDB Q46909 http://phylomedb.org/?seqid=Q46909 ProteinModelPortal Q46909 http://www.proteinmodelportal.org/query/uniprot/Q46909 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417251 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417251 RefSeq WP_001098105 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001098105 STRING 511145.b2771 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2771&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.1.95 http://www.tcdb.org/search/result.php?tc=2.A.1.1.95 UniProtKB YGCS_ECOLI http://www.uniprot.org/uniprot/YGCS_ECOLI UniProtKB-AC Q46909 http://www.uniprot.org/uniprot/Q46909 charge swissprot:YGCS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGCS_ECOLI eggNOG ENOG4105C54 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C54 eggNOG ENOG410XQKC http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XQKC epestfind swissprot:YGCS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGCS_ECOLI garnier swissprot:YGCS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGCS_ECOLI helixturnhelix swissprot:YGCS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGCS_ECOLI hmoment swissprot:YGCS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGCS_ECOLI iep swissprot:YGCS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGCS_ECOLI inforesidue swissprot:YGCS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGCS_ECOLI octanol swissprot:YGCS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGCS_ECOLI pepcoil swissprot:YGCS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGCS_ECOLI pepdigest swissprot:YGCS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGCS_ECOLI pepinfo swissprot:YGCS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGCS_ECOLI pepnet swissprot:YGCS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGCS_ECOLI pepstats swissprot:YGCS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGCS_ECOLI pepwheel swissprot:YGCS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGCS_ECOLI pepwindow swissprot:YGCS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGCS_ECOLI sigcleave swissprot:YGCS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGCS_ECOLI ## Database ID URL or Descriptions # BioGrid 4262125 26 # EcoGene EG14004 ynjB # InterPro IPR027020 YnjB # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00192 Putative thiamine transport system # KEGG_Brite ko02000 Transporters # Organism YNJB_ECOLI Escherichia coli (strain K12) # PATRIC 32118819 VBIEscCol129921_1827 # PIR B64935 B64935 # PIRSF PIRSF029172 UCP029172_ABC_sbc_YnjB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNJB_ECOLI Protein YnjB # RefSeq NP_416268 NC_000913.3 # RefSeq WP_001215339 NZ_LN832404.1 # eggNOG COG4134 LUCA # eggNOG ENOG4105VNH Bacteria BLAST swissprot:YNJB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNJB_ECOLI BioCyc ECOL316407:JW5284-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5284-MONOMER BioCyc EcoCyc:G6949-MONOMER http://biocyc.org/getid?id=EcoCyc:G6949-MONOMER COG COG4134 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4134 DIP DIP-12779N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12779N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1432-1327.2000.01296.x http://dx.doi.org/10.1046/j.1432-1327.2000.01296.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3760 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3760 EcoGene EG14004 http://www.ecogene.org/geneInfo.php?eg_id=EG14004 EnsemblBacteria AAC74824 http://www.ensemblgenomes.org/id/AAC74824 EnsemblBacteria AAC74824 http://www.ensemblgenomes.org/id/AAC74824 EnsemblBacteria BAE76521 http://www.ensemblgenomes.org/id/BAE76521 EnsemblBacteria BAE76521 http://www.ensemblgenomes.org/id/BAE76521 EnsemblBacteria BAE76521 http://www.ensemblgenomes.org/id/BAE76521 EnsemblBacteria b1754 http://www.ensemblgenomes.org/id/b1754 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946271 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946271 HOGENOM HOG000275285 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275285&db=HOGENOM6 InParanoid P76223 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76223 InterPro IPR027020 http://www.ebi.ac.uk/interpro/entry/IPR027020 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5284 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5284 KEGG_Gene eco:b1754 http://www.genome.jp/dbget-bin/www_bget?eco:b1754 KEGG_Orthology KO:K05777 http://www.genome.jp/dbget-bin/www_bget?KO:K05777 OMA PLWAYLD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PLWAYLD PSORT swissprot:YNJB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNJB_ECOLI PSORT-B swissprot:YNJB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNJB_ECOLI PSORT2 swissprot:YNJB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNJB_ECOLI Phobius swissprot:YNJB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNJB_ECOLI ProteinModelPortal P76223 http://www.proteinmodelportal.org/query/uniprot/P76223 PubMed 10806384 http://www.ncbi.nlm.nih.gov/pubmed/10806384 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416268 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416268 RefSeq WP_001215339 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001215339 STRING 511145.b1754 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1754&targetmode=cogs STRING COG4134 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4134&targetmode=cogs UniProtKB YNJB_ECOLI http://www.uniprot.org/uniprot/YNJB_ECOLI UniProtKB-AC P76223 http://www.uniprot.org/uniprot/P76223 charge swissprot:YNJB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNJB_ECOLI eggNOG COG4134 http://eggnogapi.embl.de/nog_data/html/tree/COG4134 eggNOG ENOG4105VNH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VNH epestfind swissprot:YNJB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNJB_ECOLI garnier swissprot:YNJB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNJB_ECOLI helixturnhelix swissprot:YNJB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNJB_ECOLI hmoment swissprot:YNJB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNJB_ECOLI iep swissprot:YNJB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNJB_ECOLI inforesidue swissprot:YNJB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNJB_ECOLI octanol swissprot:YNJB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNJB_ECOLI pepcoil swissprot:YNJB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNJB_ECOLI pepdigest swissprot:YNJB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNJB_ECOLI pepinfo swissprot:YNJB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNJB_ECOLI pepnet swissprot:YNJB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNJB_ECOLI pepstats swissprot:YNJB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNJB_ECOLI pepwheel swissprot:YNJB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNJB_ECOLI pepwindow swissprot:YNJB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNJB_ECOLI sigcleave swissprot:YNJB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNJB_ECOLI ## Database ID URL or Descriptions # AltName SAFA_ECOLI Regulatory protein b1500 # AltName SAFA_ECOLI Sensor associating factor A # EcoGene EG14466 safA # FUNCTION SAFA_ECOLI Connects the signal transduction between the two- component systems EvgS/EvgA and PhoQ/PhoP, by directly interacting with PhoQ and thus activating the PhoQ/PhoP system, in response to acid stress conditions. {ECO 0000269|PubMed 17998538}. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # INDUCTION SAFA_ECOLI By acid stress, via the EvgS/EvgA system. {ECO 0000269|PubMed 12694615, ECO 0000269|PubMed 19352034}. # InterPro IPR031411 SafA # Organism SAFA_ECOLI Escherichia coli (strain K12) # PATRIC 32118294 VBIEscCol129921_1567 # PIR G64903 G64903 # Pfam PF17073 SafA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SAFA_ECOLI Two-component-system connector protein SafA # RefSeq NP_416017 NC_000913.3 # RefSeq WP_000543384 NZ_LN832404.1 # SIMILARITY Belongs to the SafA family. {ECO 0000305}. # SUBCELLULAR LOCATION SAFA_ECOLI Cell inner membrane {ECO 0000269|PubMed 17998538}; Single-pass type II membrane protein {ECO 0000269|PubMed 17998538}. # SUBUNIT Interacts with PhoQ. {ECO:0000269|PubMed 17998538}. BLAST swissprot:SAFA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SAFA_ECOLI BioCyc EcoCyc:MONOMER0-2841 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2841 DIP DIP-46181N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-46181N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2003.03477.x http://dx.doi.org/10.1046/j.1365-2958.2003.03477.x DOI 10.1073/pnas.0705768104 http://dx.doi.org/10.1073/pnas.0705768104 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1271/bbb.80795 http://dx.doi.org/10.1271/bbb.80795 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14466 http://www.ecogene.org/geneInfo.php?eg_id=EG14466 EnsemblBacteria AAC74573 http://www.ensemblgenomes.org/id/AAC74573 EnsemblBacteria AAC74573 http://www.ensemblgenomes.org/id/AAC74573 EnsemblBacteria b1500 http://www.ensemblgenomes.org/id/b1500 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GeneID 946061 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946061 HOGENOM HOG000059395 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000059395&db=HOGENOM6 InterPro IPR031411 http://www.ebi.ac.uk/interpro/entry/IPR031411 KEGG_Gene eco:b1500 http://www.genome.jp/dbget-bin/www_bget?eco:b1500 OMA NYKGIMS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NYKGIMS PSORT swissprot:SAFA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SAFA_ECOLI PSORT-B swissprot:SAFA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SAFA_ECOLI PSORT2 swissprot:SAFA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SAFA_ECOLI Pfam PF17073 http://pfam.xfam.org/family/PF17073 Phobius swissprot:SAFA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SAFA_ECOLI ProteinModelPortal P76136 http://www.proteinmodelportal.org/query/uniprot/P76136 PubMed 12694615 http://www.ncbi.nlm.nih.gov/pubmed/12694615 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17998538 http://www.ncbi.nlm.nih.gov/pubmed/17998538 PubMed 19352034 http://www.ncbi.nlm.nih.gov/pubmed/19352034 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416017 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416017 RefSeq WP_000543384 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000543384 STRING 511145.b1500 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1500&targetmode=cogs UniProtKB SAFA_ECOLI http://www.uniprot.org/uniprot/SAFA_ECOLI UniProtKB-AC P76136 http://www.uniprot.org/uniprot/P76136 charge swissprot:SAFA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SAFA_ECOLI epestfind swissprot:SAFA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SAFA_ECOLI garnier swissprot:SAFA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SAFA_ECOLI helixturnhelix swissprot:SAFA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SAFA_ECOLI hmoment swissprot:SAFA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SAFA_ECOLI iep swissprot:SAFA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SAFA_ECOLI inforesidue swissprot:SAFA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SAFA_ECOLI octanol swissprot:SAFA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SAFA_ECOLI pepcoil swissprot:SAFA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SAFA_ECOLI pepdigest swissprot:SAFA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SAFA_ECOLI pepinfo swissprot:SAFA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SAFA_ECOLI pepnet swissprot:SAFA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SAFA_ECOLI pepstats swissprot:SAFA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SAFA_ECOLI pepwheel swissprot:SAFA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SAFA_ECOLI pepwindow swissprot:SAFA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SAFA_ECOLI sigcleave swissprot:SAFA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SAFA_ECOLI ## Database ID URL or Descriptions # AltName GCST_ECOLI Glycine cleavage system T protein # BioGrid 4262343 12 # CATALYTIC ACTIVITY GCST_ECOLI [Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10- methylenetetrahydrofolate + NH(3). # EcoGene EG11442 gcvT # FUNCTION GCST_ECOLI The glycine cleavage system catalyzes the degradation of glycine. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004047 aminomethyltransferase activity; IDA:EcoCyc. # GO_function GO:0008483 transaminase activity; IEA:UniProtKB-KW. # GO_process GO:0019464 glycine decarboxylation via glycine cleavage system; ISS:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # Gene3D 2.40.30.110 -; 1. # Gene3D 3.30.1360.120 -; 2. # HAMAP MF_00259 GcvT # IntAct P27248 6 # InterPro IPR006222 GCV_T_N # InterPro IPR006223 GCS_T # InterPro IPR013977 GCV_T_C # InterPro IPR022903 GCS_T_bac # InterPro IPR027266 TrmE/GcvT_dom1 # InterPro IPR028896 GCST/DmdA # InterPro IPR029043 GcvT/YgfZ_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00260 Glycine, serine and threonine metabolism # KEGG_Pathway ko00670 One carbon pool by folate # KEGG_Pathway ko00910 Nitrogen metabolism # Organism GCST_ECOLI Escherichia coli (strain K12) # PANTHER PTHR13847:SF5 PTHR13847:SF5 # PATRIC 32121224 VBIEscCol129921_3000 # PDB 1VLO X-ray; 1.70 A; A=2-363 # PDB 3A8I X-ray; 1.99 A; A/B/C/D=1-364 # PDB 3A8J X-ray; 1.98 A; A/B/C/D=1-364 # PDB 3A8K X-ray; 1.95 A; A/B/C/D=1-364 # PIR A56689 A56689 # PIRSF PIRSF006487 GcvT # Pfam PF01571 GCV_T # Pfam PF08669 GCV_T_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GCST_ECOLI Aminomethyltransferase # RefSeq NP_417381 NC_000913.3 # RefSeq WP_000068701 NZ_LN832404.1 # SIMILARITY Belongs to the GcvT family. {ECO 0000305}. # SUBUNIT The glycine cleavage system is composed of four proteins P, T, L and H. # SUPFAM SSF101790 SSF101790 # TIGRFAMs TIGR00528 gcvT # eggNOG COG0404 LUCA # eggNOG ENOG4105D43 Bacteria BLAST swissprot:GCST_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GCST_ECOLI BioCyc ECOL316407:JW2873-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2873-MONOMER BioCyc EcoCyc:GCVT-MONOMER http://biocyc.org/getid?id=EcoCyc:GCVT-MONOMER BioCyc MetaCyc:GCVT-MONOMER http://biocyc.org/getid?id=MetaCyc:GCVT-MONOMER COG COG0404 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0404 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1432-1033.1993.tb18172.x http://dx.doi.org/10.1111/j.1432-1033.1993.tb18172.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.2.10 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.2.10 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M97263 http://www.ebi.ac.uk/ena/data/view/M97263 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EMBL X73958 http://www.ebi.ac.uk/ena/data/view/X73958 ENZYME 2.1.2.10 http://enzyme.expasy.org/EC/2.1.2.10 EchoBASE EB1412 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1412 EcoGene EG11442 http://www.ecogene.org/geneInfo.php?eg_id=EG11442 EnsemblBacteria AAC75943 http://www.ensemblgenomes.org/id/AAC75943 EnsemblBacteria AAC75943 http://www.ensemblgenomes.org/id/AAC75943 EnsemblBacteria BAE76970 http://www.ensemblgenomes.org/id/BAE76970 EnsemblBacteria BAE76970 http://www.ensemblgenomes.org/id/BAE76970 EnsemblBacteria BAE76970 http://www.ensemblgenomes.org/id/BAE76970 EnsemblBacteria b2905 http://www.ensemblgenomes.org/id/b2905 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004047 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004047 GO_function GO:0008483 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008483 GO_process GO:0019464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019464 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 2.40.30.110 http://www.cathdb.info/version/latest/superfamily/2.40.30.110 Gene3D 3.30.1360.120 http://www.cathdb.info/version/latest/superfamily/3.30.1360.120 GeneID 947390 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947390 HAMAP MF_00259 http://hamap.expasy.org/unirule/MF_00259 HOGENOM HOG000239381 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000239381&db=HOGENOM6 InParanoid P27248 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P27248 IntAct P27248 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P27248* IntEnz 2.1.2.10 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.2.10 InterPro IPR006222 http://www.ebi.ac.uk/interpro/entry/IPR006222 InterPro IPR006223 http://www.ebi.ac.uk/interpro/entry/IPR006223 InterPro IPR013977 http://www.ebi.ac.uk/interpro/entry/IPR013977 InterPro IPR022903 http://www.ebi.ac.uk/interpro/entry/IPR022903 InterPro IPR027266 http://www.ebi.ac.uk/interpro/entry/IPR027266 InterPro IPR028896 http://www.ebi.ac.uk/interpro/entry/IPR028896 InterPro IPR029043 http://www.ebi.ac.uk/interpro/entry/IPR029043 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2873 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2873 KEGG_Gene eco:b2905 http://www.genome.jp/dbget-bin/www_bget?eco:b2905 KEGG_Orthology KO:K00605 http://www.genome.jp/dbget-bin/www_bget?KO:K00605 KEGG_Pathway ko00260 http://www.genome.jp/kegg-bin/show_pathway?ko00260 KEGG_Pathway ko00670 http://www.genome.jp/kegg-bin/show_pathway?ko00670 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Reaction rn:R01221 http://www.genome.jp/dbget-bin/www_bget?rn:R01221 KEGG_Reaction rn:R02300 http://www.genome.jp/dbget-bin/www_bget?rn:R02300 KEGG_Reaction rn:R04125 http://www.genome.jp/dbget-bin/www_bget?rn:R04125 OMA LGWLVHL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LGWLVHL PANTHER PTHR13847:SF5 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13847:SF5 PDB 1VLO http://www.ebi.ac.uk/pdbe-srv/view/entry/1VLO PDB 3A8I http://www.ebi.ac.uk/pdbe-srv/view/entry/3A8I PDB 3A8J http://www.ebi.ac.uk/pdbe-srv/view/entry/3A8J PDB 3A8K http://www.ebi.ac.uk/pdbe-srv/view/entry/3A8K PDBsum 1VLO http://www.ebi.ac.uk/pdbsum/1VLO PDBsum 3A8I http://www.ebi.ac.uk/pdbsum/3A8I PDBsum 3A8J http://www.ebi.ac.uk/pdbsum/3A8J PDBsum 3A8K http://www.ebi.ac.uk/pdbsum/3A8K PSORT swissprot:GCST_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GCST_ECOLI PSORT-B swissprot:GCST_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GCST_ECOLI PSORT2 swissprot:GCST_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GCST_ECOLI Pfam PF01571 http://pfam.xfam.org/family/PF01571 Pfam PF08669 http://pfam.xfam.org/family/PF08669 Phobius swissprot:GCST_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GCST_ECOLI PhylomeDB P27248 http://phylomedb.org/?seqid=P27248 ProteinModelPortal P27248 http://www.proteinmodelportal.org/query/uniprot/P27248 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8219277 http://www.ncbi.nlm.nih.gov/pubmed/8219277 PubMed 8375392 http://www.ncbi.nlm.nih.gov/pubmed/8375392 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_417381 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417381 RefSeq WP_000068701 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000068701 SMR P27248 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P27248 STRING 511145.b2905 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2905&targetmode=cogs STRING COG0404 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0404&targetmode=cogs SUPFAM SSF101790 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF101790 TIGRFAMs TIGR00528 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00528 UniProtKB GCST_ECOLI http://www.uniprot.org/uniprot/GCST_ECOLI UniProtKB-AC P27248 http://www.uniprot.org/uniprot/P27248 charge swissprot:GCST_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GCST_ECOLI eggNOG COG0404 http://eggnogapi.embl.de/nog_data/html/tree/COG0404 eggNOG ENOG4105D43 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D43 epestfind swissprot:GCST_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GCST_ECOLI garnier swissprot:GCST_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GCST_ECOLI helixturnhelix swissprot:GCST_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GCST_ECOLI hmoment swissprot:GCST_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GCST_ECOLI iep swissprot:GCST_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GCST_ECOLI inforesidue swissprot:GCST_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GCST_ECOLI octanol swissprot:GCST_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GCST_ECOLI pepcoil swissprot:GCST_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GCST_ECOLI pepdigest swissprot:GCST_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GCST_ECOLI pepinfo swissprot:GCST_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GCST_ECOLI pepnet swissprot:GCST_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GCST_ECOLI pepstats swissprot:GCST_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GCST_ECOLI pepwheel swissprot:GCST_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GCST_ECOLI pepwindow swissprot:GCST_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GCST_ECOLI sigcleave swissprot:GCST_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GCST_ECOLI ## Database ID URL or Descriptions # BioGrid 4261324 17 # CATALYTIC ACTIVITY GSHR_ECOLI 2 glutathione + NADP(+) = glutathione disulfide + NADPH. # COFACTOR Name=FAD; Xref=ChEBI:CHEBI 57692; Note=Binds 1 FAD per subunit.; # DrugBank DB00336 Nitrofural # DrugBank DB03147 Flavin adenine dinucleotide # EcoGene EG10412 gor # FUNCTION GSHR_ECOLI Maintains high levels of reduced glutathione in the cytosol. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0004362 glutathione-disulfide reductase activity; IDA:EcoCyc. # GO_function GO:0050661 NADP binding; IEA:InterPro. # GO_function GO:0071949 FAD binding; IDA:EcoCyc. # GO_process GO:0006749 glutathione metabolic process; IEA:InterPro. # GO_process GO:0045454 cell redox homeostasis; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0042592 homeostatic process # Gene3D 3.30.390.30 -; 1. # Gene3D 3.50.50.60 -; 3. # IntAct P06715 3 # InterPro IPR004099 Pyr_nucl-diS_OxRdtase_dimer # InterPro IPR006322 Glutathione_Rdtase_euk/bac # InterPro IPR012999 Pyr_OxRdtase_I_AS # InterPro IPR016156 FAD/NAD-linked_Rdtase_dimer # InterPro IPR023753 FAD/NAD-binding_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00480 Glutathione metabolism # MISCELLANEOUS GSHR_ECOLI The active site is a redox-active disulfide bond. # Organism GSHR_ECOLI Escherichia coli (strain K12) # PATRIC 32122450 VBIEscCol129921_3602 # PDB 1GER X-ray; 1.86 A; A/B=1-450 # PDB 1GES X-ray; 1.74 A; A/B=1-450 # PDB 1GET X-ray; 2.00 A; A/B=1-450 # PDB 1GEU X-ray; 2.20 A; A/B=1-450 # PIR A24409 RDECU # PROSITE PS00076 PYRIDINE_REDOX_1 # Pfam PF02852 Pyr_redox_dim # Pfam PF07992 Pyr_redox_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GSHR_ECOLI Glutathione reductase # RefSeq NP_417957 NC_000913.3 # RefSeq WP_000160816 NZ_CP014270.1 # SIMILARITY Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. {ECO 0000305}. # SUBCELLULAR LOCATION GSHR_ECOLI Cytoplasm. # SUBUNIT GSHR_ECOLI Homodimer. # SUPFAM SSF51905 SSF51905 # SUPFAM SSF55424 SSF55424 # TIGRFAMs TIGR01421 gluta_reduc_1 # eggNOG COG1249 LUCA # eggNOG ENOG4105DC8 Bacteria BLAST swissprot:GSHR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GSHR_ECOLI BioCyc ECOL316407:JW3467-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3467-MONOMER BioCyc EcoCyc:GLUTATHIONE-REDUCT-NADPH-MONOMER http://biocyc.org/getid?id=EcoCyc:GLUTATHIONE-REDUCT-NADPH-MONOMER BioCyc MetaCyc:GLUTATHIONE-REDUCT-NADPH-MONOMER http://biocyc.org/getid?id=MetaCyc:GLUTATHIONE-REDUCT-NADPH-MONOMER COG COG1249 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1249 DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/pro.5560030509 http://dx.doi.org/10.1002/pro.5560030509 DOI 10.1002/prot.340090303 http://dx.doi.org/10.1002/prot.340090303 DOI 10.1021/bi00357a069 http://dx.doi.org/10.1021/bi00357a069 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB00336 http://www.drugbank.ca/drugs/DB00336 DrugBank DB03147 http://www.drugbank.ca/drugs/DB03147 EC_number EC:1.8.1.7 http://www.genome.jp/dbget-bin/www_bget?EC:1.8.1.7 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M13141 http://www.ebi.ac.uk/ena/data/view/M13141 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.8.1.7 http://enzyme.expasy.org/EC/1.8.1.7 EchoBASE EB0407 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0407 EcoGene EG10412 http://www.ecogene.org/geneInfo.php?eg_id=EG10412 EnsemblBacteria AAC76525 http://www.ensemblgenomes.org/id/AAC76525 EnsemblBacteria AAC76525 http://www.ensemblgenomes.org/id/AAC76525 EnsemblBacteria BAE77794 http://www.ensemblgenomes.org/id/BAE77794 EnsemblBacteria BAE77794 http://www.ensemblgenomes.org/id/BAE77794 EnsemblBacteria BAE77794 http://www.ensemblgenomes.org/id/BAE77794 EnsemblBacteria b3500 http://www.ensemblgenomes.org/id/b3500 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0004362 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004362 GO_function GO:0050661 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050661 GO_function GO:0071949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071949 GO_process GO:0006749 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006749 GO_process GO:0045454 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045454 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 Gene3D 3.30.390.30 http://www.cathdb.info/version/latest/superfamily/3.30.390.30 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 GeneID 948014 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948014 HOGENOM HOG000276712 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276712&db=HOGENOM6 InParanoid P06715 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P06715 IntAct P06715 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P06715* IntEnz 1.8.1.7 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.8.1.7 InterPro IPR004099 http://www.ebi.ac.uk/interpro/entry/IPR004099 InterPro IPR006322 http://www.ebi.ac.uk/interpro/entry/IPR006322 InterPro IPR012999 http://www.ebi.ac.uk/interpro/entry/IPR012999 InterPro IPR016156 http://www.ebi.ac.uk/interpro/entry/IPR016156 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3467 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3467 KEGG_Gene eco:b3500 http://www.genome.jp/dbget-bin/www_bget?eco:b3500 KEGG_Orthology KO:K00383 http://www.genome.jp/dbget-bin/www_bget?KO:K00383 KEGG_Pathway ko00480 http://www.genome.jp/kegg-bin/show_pathway?ko00480 KEGG_Reaction rn:R00094 http://www.genome.jp/dbget-bin/www_bget?rn:R00094 KEGG_Reaction rn:R00115 http://www.genome.jp/dbget-bin/www_bget?rn:R00115 OMA HLYAKDY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HLYAKDY PDB 1GER http://www.ebi.ac.uk/pdbe-srv/view/entry/1GER PDB 1GES http://www.ebi.ac.uk/pdbe-srv/view/entry/1GES PDB 1GET http://www.ebi.ac.uk/pdbe-srv/view/entry/1GET PDB 1GEU http://www.ebi.ac.uk/pdbe-srv/view/entry/1GEU PDBsum 1GER http://www.ebi.ac.uk/pdbsum/1GER PDBsum 1GES http://www.ebi.ac.uk/pdbsum/1GES PDBsum 1GET http://www.ebi.ac.uk/pdbsum/1GET PDBsum 1GEU http://www.ebi.ac.uk/pdbsum/1GEU PROSITE PS00076 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00076 PSORT swissprot:GSHR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GSHR_ECOLI PSORT-B swissprot:GSHR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GSHR_ECOLI PSORT2 swissprot:GSHR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GSHR_ECOLI Pfam PF02852 http://pfam.xfam.org/family/PF02852 Pfam PF07992 http://pfam.xfam.org/family/PF07992 Phobius swissprot:GSHR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GSHR_ECOLI PhylomeDB P06715 http://phylomedb.org/?seqid=P06715 ProteinModelPortal P06715 http://www.proteinmodelportal.org/query/uniprot/P06715 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2006135 http://www.ncbi.nlm.nih.gov/pubmed/2006135 PubMed 3521741 http://www.ncbi.nlm.nih.gov/pubmed/3521741 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 8061609 http://www.ncbi.nlm.nih.gov/pubmed/8061609 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417957 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417957 RefSeq WP_000160816 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000160816 SMR P06715 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P06715 STRING 511145.b3500 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3500&targetmode=cogs STRING COG1249 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1249&targetmode=cogs SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 SUPFAM SSF55424 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55424 SWISS-2DPAGE P06715 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P06715 TIGRFAMs TIGR01421 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01421 UniProtKB GSHR_ECOLI http://www.uniprot.org/uniprot/GSHR_ECOLI UniProtKB-AC P06715 http://www.uniprot.org/uniprot/P06715 charge swissprot:GSHR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GSHR_ECOLI eggNOG COG1249 http://eggnogapi.embl.de/nog_data/html/tree/COG1249 eggNOG ENOG4105DC8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DC8 epestfind swissprot:GSHR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GSHR_ECOLI garnier swissprot:GSHR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GSHR_ECOLI helixturnhelix swissprot:GSHR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GSHR_ECOLI hmoment swissprot:GSHR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GSHR_ECOLI iep swissprot:GSHR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GSHR_ECOLI inforesidue swissprot:GSHR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GSHR_ECOLI octanol swissprot:GSHR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GSHR_ECOLI pepcoil swissprot:GSHR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GSHR_ECOLI pepdigest swissprot:GSHR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GSHR_ECOLI pepinfo swissprot:GSHR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GSHR_ECOLI pepnet swissprot:GSHR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GSHR_ECOLI pepstats swissprot:GSHR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GSHR_ECOLI pepwheel swissprot:GSHR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GSHR_ECOLI pepwindow swissprot:GSHR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GSHR_ECOLI sigcleave swissprot:GSHR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GSHR_ECOLI ## Database ID URL or Descriptions # BioGrid 4261157 4 # CATALYTIC ACTIVITY AGAA_ECOLI N-acetyl-D-galactosamine 6-phosphate + H(2)O = D-galactosamine 6-phosphate + acetate. # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG12766 agaA # GO_function GO:0000034 adenine deaminase activity; IBA:GO_Central. # GO_process GO:0005975 carbohydrate metabolic process; IEA:UniProtKB-KW. # GO_process GO:0006146 adenine catabolic process; IBA:GO_Central. # GO_process GO:0046101 hypoxanthine biosynthetic process; IBA:GO_Central. # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 2.30.40.10 -; 1. # InterPro IPR006680 Amidohydro-rel # InterPro IPR011059 Metal-dep_hydrolase_composite # InterPro IPR032466 Metal_Hydrolase # MISCELLANEOUS AGAA_ECOLI In contrast to E.coli strains C and EC3132, K-12 strains cannot grow on N-acetylgalactosamine and D-galactosamine, because they carry a deletion and thus lack active PTS systems specific for these compounds. Therefore, AgaA in K-12 strains is not involved in the degradation of these compounds. # Organism AGAA_ECOLI Escherichia coli (strain K12) # PATRIC 48665721 VBIEscCol107702_3166 # PIR C65103 C65103 # Pfam PF01979 Amidohydro_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AGAA_ECOLI Putative N-acetylgalactosamine-6-phosphate deacetylase # SEQUENCE CAUTION Sequence=AAA57938.1; Type=Frameshift; Positions=114; Evidence={ECO 0000305}; # SIMILARITY Belongs to the NagA family. {ECO 0000305}. # SUPFAM SSF51556 SSF51556 # eggNOG COG1820 LUCA BLAST swissprot:AGAA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AGAA_ECOLI BioCyc ECOL316407:JW5527-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5527-MONOMER BioCyc EcoCyc:AGAA-MONOMER http://biocyc.org/getid?id=EcoCyc:AGAA-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1099/13500872-142-2-231 http://dx.doi.org/10.1099/13500872-142-2-231 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.5.1.- http://www.genome.jp/dbget-bin/www_bget?EC:3.5.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 3.5.1.- http://enzyme.expasy.org/EC/3.5.1.- EchoBASE EB2619 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2619 EcoGene EG12766 http://www.ecogene.org/geneInfo.php?eg_id=EG12766 EnsemblBacteria BAE77181 http://www.ensemblgenomes.org/id/BAE77181 EnsemblBacteria BAE77181 http://www.ensemblgenomes.org/id/BAE77181 EnsemblBacteria BAE77181 http://www.ensemblgenomes.org/id/BAE77181 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000034 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000034 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GO_process GO:0006146 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006146 GO_process GO:0046101 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046101 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 2.30.40.10 http://www.cathdb.info/version/latest/superfamily/2.30.40.10 HOGENOM HOG000202514 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000202514&db=HOGENOM6 InParanoid P42906 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P42906 IntEnz 3.5.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.1 InterPro IPR006680 http://www.ebi.ac.uk/interpro/entry/IPR006680 InterPro IPR011059 http://www.ebi.ac.uk/interpro/entry/IPR011059 InterPro IPR032466 http://www.ebi.ac.uk/interpro/entry/IPR032466 KEGG_Gene ecj:JW5527 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5527 OMA MCHSTAN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MCHSTAN PSORT swissprot:AGAA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AGAA_ECOLI PSORT-B swissprot:AGAA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AGAA_ECOLI PSORT2 swissprot:AGAA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AGAA_ECOLI Pfam PF01979 http://pfam.xfam.org/family/PF01979 Phobius swissprot:AGAA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AGAA_ECOLI PhylomeDB P42906 http://phylomedb.org/?seqid=P42906 ProteinModelPortal P42906 http://www.proteinmodelportal.org/query/uniprot/P42906 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8932697 http://www.ncbi.nlm.nih.gov/pubmed/8932697 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SMR P42906 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P42906 STRING 316407.85675931 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85675931&targetmode=cogs SUPFAM SSF51556 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51556 UniProtKB AGAA_ECOLI http://www.uniprot.org/uniprot/AGAA_ECOLI UniProtKB-AC P42906 http://www.uniprot.org/uniprot/P42906 charge swissprot:AGAA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AGAA_ECOLI eggNOG COG1820 http://eggnogapi.embl.de/nog_data/html/tree/COG1820 epestfind swissprot:AGAA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AGAA_ECOLI garnier swissprot:AGAA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AGAA_ECOLI helixturnhelix swissprot:AGAA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AGAA_ECOLI hmoment swissprot:AGAA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AGAA_ECOLI iep swissprot:AGAA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AGAA_ECOLI inforesidue swissprot:AGAA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AGAA_ECOLI octanol swissprot:AGAA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AGAA_ECOLI pepcoil swissprot:AGAA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AGAA_ECOLI pepdigest swissprot:AGAA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AGAA_ECOLI pepinfo swissprot:AGAA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AGAA_ECOLI pepnet swissprot:AGAA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AGAA_ECOLI pepstats swissprot:AGAA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AGAA_ECOLI pepwheel swissprot:AGAA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AGAA_ECOLI pepwindow swissprot:AGAA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AGAA_ECOLI sigcleave swissprot:AGAA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AGAA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259670 4 # EcoGene EG13960 ydhZ # IntAct P0ACX5 10 # InterPro IPR024493 DUF2767 # Organism YDHZ_ECOLI Escherichia coli (strain K12) # PATRIC 32118656 VBIEscCol129921_1746 # PIR C64925 C64925 # Pfam PF10965 DUF2767 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDHZ_ECOLI Uncharacterized protein YdhZ # RefSeq NP_416190 NC_000913.3 # RefSeq WP_000528342 NZ_LN832404.1 # eggNOG ENOG4105RFR Bacteria # eggNOG ENOG4111YPS LUCA BLAST swissprot:YDHZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDHZ_ECOLI BioCyc ECOL316407:JW1665-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1665-MONOMER BioCyc EcoCyc:G6903-MONOMER http://biocyc.org/getid?id=EcoCyc:G6903-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U68703 http://www.ebi.ac.uk/ena/data/view/U68703 EchoBASE EB3718 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3718 EcoGene EG13960 http://www.ecogene.org/geneInfo.php?eg_id=EG13960 EnsemblBacteria AAC74745 http://www.ensemblgenomes.org/id/AAC74745 EnsemblBacteria AAC74745 http://www.ensemblgenomes.org/id/AAC74745 EnsemblBacteria BAE76499 http://www.ensemblgenomes.org/id/BAE76499 EnsemblBacteria BAE76499 http://www.ensemblgenomes.org/id/BAE76499 EnsemblBacteria BAE76499 http://www.ensemblgenomes.org/id/BAE76499 EnsemblBacteria b1675 http://www.ensemblgenomes.org/id/b1675 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946180 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946180 HOGENOM HOG000267905 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267905&db=HOGENOM6 IntAct P0ACX5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACX5* InterPro IPR024493 http://www.ebi.ac.uk/interpro/entry/IPR024493 KEGG_Gene ecj:JW1665 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1665 KEGG_Gene eco:b1675 http://www.genome.jp/dbget-bin/www_bget?eco:b1675 OMA ALYQEMC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ALYQEMC PSORT swissprot:YDHZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDHZ_ECOLI PSORT-B swissprot:YDHZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDHZ_ECOLI PSORT2 swissprot:YDHZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDHZ_ECOLI Pfam PF10965 http://pfam.xfam.org/family/PF10965 Phobius swissprot:YDHZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDHZ_ECOLI ProteinModelPortal P0ACX5 http://www.proteinmodelportal.org/query/uniprot/P0ACX5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9023191 http://www.ncbi.nlm.nih.gov/pubmed/9023191 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416190 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416190 RefSeq WP_000528342 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000528342 STRING 511145.b1675 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1675&targetmode=cogs UniProtKB YDHZ_ECOLI http://www.uniprot.org/uniprot/YDHZ_ECOLI UniProtKB-AC P0ACX5 http://www.uniprot.org/uniprot/P0ACX5 charge swissprot:YDHZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDHZ_ECOLI eggNOG ENOG4105RFR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105RFR eggNOG ENOG4111YPS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111YPS epestfind swissprot:YDHZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDHZ_ECOLI garnier swissprot:YDHZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDHZ_ECOLI helixturnhelix swissprot:YDHZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDHZ_ECOLI hmoment swissprot:YDHZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDHZ_ECOLI iep swissprot:YDHZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDHZ_ECOLI inforesidue swissprot:YDHZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDHZ_ECOLI octanol swissprot:YDHZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDHZ_ECOLI pepcoil swissprot:YDHZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDHZ_ECOLI pepdigest swissprot:YDHZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDHZ_ECOLI pepinfo swissprot:YDHZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDHZ_ECOLI pepnet swissprot:YDHZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDHZ_ECOLI pepstats swissprot:YDHZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDHZ_ECOLI pepwheel swissprot:YDHZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDHZ_ECOLI pepwindow swissprot:YDHZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDHZ_ECOLI sigcleave swissprot:YDHZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDHZ_ECOLI ## Database ID URL or Descriptions # BioGrid 4261686 4 # DISRUPTION PHENOTYPE Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain. {ECO:0000269|PubMed 20345943}. # EcoGene EG13884 sfmH # FUNCTION SFMH_ECOLI Part of the sfmACDHF fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes. {ECO 0000269|PubMed 20345943}. # GO_component GO:0009289 pilus; IEA:UniProtKB-SubCell. # GO_function GO:0005537 mannose binding; IEA:UniProtKB-KW. # GO_process GO:0007155 cell adhesion; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0007155 cell adhesion # Gene3D 2.60.40.1090 -; 1. # INDUCTION Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression. {ECO:0000269|PubMed 20345943}. # InterPro IPR000259 Adhesion_dom_fimbrial # InterPro IPR008966 Adhesion_dom # KEGG_Brite ko02035 Bacterial motility proteins # MISCELLANEOUS The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed. {ECO:0000305|PubMed 20345943}. # Organism SFMH_ECOLI Escherichia coli (strain K12) # PATRIC 32116226 VBIEscCol129921_0554 # PIR D64785 D64785 # Pfam PF00419 Fimbrial # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SFMH_ECOLI Uncharacterized fimbrial-like protein SfmH # RefSeq NP_415066 NC_000913.3 # SEQUENCE CAUTION Sequence=AAB40731.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAE76310.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the fimbrial protein family. {ECO 0000305}. # SUBCELLULAR LOCATION SFMH_ECOLI Fimbrium {ECO 0000250}. # SUPFAM SSF49401 SSF49401 # eggNOG ENOG4108M66 Bacteria # eggNOG ENOG410ZUTT LUCA BLAST swissprot:SFMH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SFMH_ECOLI BioCyc ECOL316407:JW5071-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5071-MONOMER BioCyc EcoCyc:G6293-MONOMER http://biocyc.org/getid?id=EcoCyc:G6293-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1462-2920.2010.02202.x http://dx.doi.org/10.1111/j.1462-2920.2010.02202.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB3643 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3643 EcoGene EG13884 http://www.ecogene.org/geneInfo.php?eg_id=EG13884 EnsemblBacteria AAC73635 http://www.ensemblgenomes.org/id/AAC73635 EnsemblBacteria AAC73635 http://www.ensemblgenomes.org/id/AAC73635 EnsemblBacteria BAE76310 http://www.ensemblgenomes.org/id/BAE76310 EnsemblBacteria BAE76310 http://www.ensemblgenomes.org/id/BAE76310 EnsemblBacteria BAE76310 http://www.ensemblgenomes.org/id/BAE76310 EnsemblBacteria b0533 http://www.ensemblgenomes.org/id/b0533 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009289 GO_function GO:0005537 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005537 GO_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 Gene3D 2.60.40.1090 http://www.cathdb.info/version/latest/superfamily/2.60.40.1090 GeneID 945407 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945407 HOGENOM HOG000267835 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267835&db=HOGENOM6 InParanoid P75715 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75715 InterPro IPR000259 http://www.ebi.ac.uk/interpro/entry/IPR000259 InterPro IPR008966 http://www.ebi.ac.uk/interpro/entry/IPR008966 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW5071 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5071 KEGG_Gene eco:b0533 http://www.genome.jp/dbget-bin/www_bget?eco:b0533 KEGG_Orthology KO:K07356 http://www.genome.jp/dbget-bin/www_bget?KO:K07356 OMA QMPFGVQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QMPFGVQ PSORT swissprot:SFMH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SFMH_ECOLI PSORT-B swissprot:SFMH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SFMH_ECOLI PSORT2 swissprot:SFMH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SFMH_ECOLI Pfam PF00419 http://pfam.xfam.org/family/PF00419 Phobius swissprot:SFMH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SFMH_ECOLI PhylomeDB P75715 http://phylomedb.org/?seqid=P75715 ProteinModelPortal P75715 http://www.proteinmodelportal.org/query/uniprot/P75715 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20345943 http://www.ncbi.nlm.nih.gov/pubmed/20345943 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415066 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415066 STRING 511145.b0533 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0533&targetmode=cogs SUPFAM SSF49401 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49401 UniProtKB SFMH_ECOLI http://www.uniprot.org/uniprot/SFMH_ECOLI UniProtKB-AC P75715 http://www.uniprot.org/uniprot/P75715 charge swissprot:SFMH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SFMH_ECOLI eggNOG ENOG4108M66 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108M66 eggNOG ENOG410ZUTT http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZUTT epestfind swissprot:SFMH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SFMH_ECOLI garnier swissprot:SFMH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SFMH_ECOLI helixturnhelix swissprot:SFMH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SFMH_ECOLI hmoment swissprot:SFMH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SFMH_ECOLI iep swissprot:SFMH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SFMH_ECOLI inforesidue swissprot:SFMH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SFMH_ECOLI octanol swissprot:SFMH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SFMH_ECOLI pepcoil swissprot:SFMH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SFMH_ECOLI pepdigest swissprot:SFMH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SFMH_ECOLI pepinfo swissprot:SFMH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SFMH_ECOLI pepnet swissprot:SFMH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SFMH_ECOLI pepstats swissprot:SFMH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SFMH_ECOLI pepwheel swissprot:SFMH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SFMH_ECOLI pepwindow swissprot:SFMH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SFMH_ECOLI sigcleave swissprot:SFMH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SFMH_ECOLI ## Database ID URL or Descriptions # AltName GFCB_ECOLI Group 4 capsule protein B homolog # CAUTION In E.coli K12 / MG1655 and K12 / W3110 this operon is silenced by an IS1D insertion in the promoter region. {ECO 0000305}. # EcoGene EG13731 gfcB # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GOslim_component GO:0005886 plasma membrane # Gene3D 2.40.360.10 -; 1. # InterPro IPR021308 GfcB # InterPro IPR023373 YmcC_dom # Organism GFCB_ECOLI Escherichia coli (strain K12) # PATRIC 32117195 VBIEscCol129921_1021 # PDB 2IN5 X-ray; 2.30 A; A/B=17-214 # PIR H64839 H64839 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF11102 YjbF # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GFCB_ECOLI Uncharacterized lipoprotein GfcB # RefSeq NP_415506 NC_000913.3 # RefSeq WP_001247610 NZ_LN832404.1 # SIMILARITY To E.coli YjbF. {ECO 0000305}. # SUBCELLULAR LOCATION GFCB_ECOLI Cell membrane {ECO 0000255|PROSITE- ProRule PRU00303}; Lipid-anchor {ECO 0000255|PROSITE- ProRule PRU00303}. # SUPFAM SSF159270 SSF159270 # eggNOG ENOG4108Y9B Bacteria # eggNOG ENOG4111IXI LUCA BLAST swissprot:GFCB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GFCB_ECOLI BioCyc ECOL316407:JW0969-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0969-MONOMER BioCyc EcoCyc:G6507-MONOMER http://biocyc.org/getid?id=EcoCyc:G6507-MONOMER DIP DIP-12709N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12709N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3495 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3495 EcoGene EG13731 http://www.ecogene.org/geneInfo.php?eg_id=EG13731 EnsemblBacteria AAC74071 http://www.ensemblgenomes.org/id/AAC74071 EnsemblBacteria AAC74071 http://www.ensemblgenomes.org/id/AAC74071 EnsemblBacteria BAA35751 http://www.ensemblgenomes.org/id/BAA35751 EnsemblBacteria BAA35751 http://www.ensemblgenomes.org/id/BAA35751 EnsemblBacteria BAA35751 http://www.ensemblgenomes.org/id/BAA35751 EnsemblBacteria b0986 http://www.ensemblgenomes.org/id/b0986 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 Gene3D 2.40.360.10 http://www.cathdb.info/version/latest/superfamily/2.40.360.10 GeneID 949118 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949118 HOGENOM HOG000280367 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000280367&db=HOGENOM6 IntAct P75884 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75884* InterPro IPR021308 http://www.ebi.ac.uk/interpro/entry/IPR021308 InterPro IPR023373 http://www.ebi.ac.uk/interpro/entry/IPR023373 KEGG_Gene ecj:JW0969 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0969 KEGG_Gene eco:b0986 http://www.genome.jp/dbget-bin/www_bget?eco:b0986 MINT MINT-1301421 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1301421 OMA PANAGIP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PANAGIP PDB 2IN5 http://www.ebi.ac.uk/pdbe-srv/view/entry/2IN5 PDBsum 2IN5 http://www.ebi.ac.uk/pdbsum/2IN5 PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:GFCB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GFCB_ECOLI PSORT-B swissprot:GFCB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GFCB_ECOLI PSORT2 swissprot:GFCB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GFCB_ECOLI Pfam PF11102 http://pfam.xfam.org/family/PF11102 Phobius swissprot:GFCB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GFCB_ECOLI ProteinModelPortal P75884 http://www.proteinmodelportal.org/query/uniprot/P75884 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415506 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415506 RefSeq WP_001247610 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001247610 SMR P75884 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75884 STRING 511145.b0986 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0986&targetmode=cogs SUPFAM SSF159270 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF159270 UniProtKB GFCB_ECOLI http://www.uniprot.org/uniprot/GFCB_ECOLI UniProtKB-AC P75884 http://www.uniprot.org/uniprot/P75884 charge swissprot:GFCB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GFCB_ECOLI eggNOG ENOG4108Y9B http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Y9B eggNOG ENOG4111IXI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111IXI epestfind swissprot:GFCB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GFCB_ECOLI garnier swissprot:GFCB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GFCB_ECOLI helixturnhelix swissprot:GFCB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GFCB_ECOLI hmoment swissprot:GFCB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GFCB_ECOLI iep swissprot:GFCB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GFCB_ECOLI inforesidue swissprot:GFCB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GFCB_ECOLI octanol swissprot:GFCB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GFCB_ECOLI pepcoil swissprot:GFCB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GFCB_ECOLI pepdigest swissprot:GFCB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GFCB_ECOLI pepinfo swissprot:GFCB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GFCB_ECOLI pepnet swissprot:GFCB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GFCB_ECOLI pepstats swissprot:GFCB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GFCB_ECOLI pepwheel swissprot:GFCB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GFCB_ECOLI pepwindow swissprot:GFCB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GFCB_ECOLI sigcleave swissprot:GFCB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GFCB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260102 14 # CDD cd07377 WHTH_GntR # DISRUPTION PHENOTYPE FADR_ECOLI Decreased transcription of fabA, low to no change in levels of fabB (PubMed 11859088, PubMed 21276098). Up- regulation of genes involved in beta-oxidation (fatty acid degradation, at least fadA, fadB, fadE, fadH, fadI and fadJ) (PubMed 11859088). Increased levels of fatty acids; double fadR- fabR deletions have the same phenotype, suggesting a functional fadR gene is required for fabR function (PubMed 11859088). {ECO 0000269|PubMed 11859088, ECO 0000269|PubMed 21276098}. # DOMAIN FADR_ECOLI The N-terminus binds DNA, the C-terminus (residues 83-239) is responsible for dimerization (PubMed 9388199). The C-terminal domain binds acyl-CoA (PubMed 7836365, PubMed 11296236). {ECO 0000269|PubMed 11296236, ECO 0000269|PubMed 7836365, ECO 0000269|PubMed 9388199}. # ENZYME REGULATION FADR_ECOLI Binding of FadR to DNA is specifically inhibited by long chain acyl-CoA compounds, but not by long chain fatty acids (PubMed 1569108). Long chain acyl-CoA binds directly to the protein preventing it from binding DNA, which derepresses genes for beta-oxidation and prevents activation of genes for unsaturated fatty acid biosynthesis (PubMed 7836365, PubMed 19854834). {ECO 0000269|PubMed 1569108, ECO 0000269|PubMed 19854834}. # EcoGene EG10281 fadR # FUNCTION FADR_ECOLI Multifunctional regulator of fatty acid metabolism (PubMed 1569108, PubMed 8446033, PubMed 9388199, PubMed 11859088, PubMed 19854834, PubMed 21276098). Represses transcription of at least eight genes required for fatty acid transport and beta- oxidation including fadA, fadB, fadD, fadL and fadE (PubMed 9388199). Activates transcription of at least three genes required for unsaturated fatty acid biosynthesis fabA, fabB and iclR, the gene encoding the transcriptional regulator of the aceBAK operon encoding the glyoxylate shunt enzymes (PubMed 9388199). {ECO 0000269|PubMed 11859088, ECO 0000269|PubMed 1569108, ECO 0000269|PubMed 19854834, ECO 0000269|PubMed 21276098, ECO 0000269|PubMed 7836365, ECO 0000269|PubMed 8446033, ECO 0000269|PubMed 9388199}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000062 fatty-acyl-CoA binding; IEA:InterPro. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; ISS:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-HAMAP. # GO_process GO:0019217 regulation of fatty acid metabolic process; IGI:CACAO. # GO_process GO:0019395 fatty acid oxidation; EXP:EcoCyc. # GO_process GO:0045723 positive regulation of fatty acid biosynthetic process; IMP:CACAO. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; ISS:EcoCyc. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; ISS:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.10.10 -; 1. # Gene3D 1.20.120.530 -; 1. # HAMAP MF_00696 HTH_FadR # INDUCTION By growth in the presence of long chain fatty acids (C14-C18) (PubMed:7836365). {ECO 0000269|PubMed:7836365}. # IntAct P0A8V6 2 # InterPro IPR000524 Tscrpt_reg_HTH_GntR # InterPro IPR008920 TF_FadR/GntR_C # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR014178 FA-response_TF_FadR # InterPro IPR028374 FadR_C # KEGG_Brite ko03000 Transcription factors # Organism FADR_ECOLI Escherichia coli (strain K12) # PATRIC 32117620 VBIEscCol129921_1232 # PDB 1E2X X-ray; 2.00 A; A=1-239 # PDB 1H9G X-ray; 2.10 A; A=1-239 # PDB 1H9T X-ray; 3.25 A; A/B=1-239 # PDB 1HW1 X-ray; 1.50 A; A/B=1-239 # PDB 1HW2 X-ray; 3.25 A; A/B=1-239 # PIR H64864 H64864 # PRINTS PR00035 HTHGNTR # PROSITE PS50949 HTH_GNTR # Pfam PF00392 GntR # Pfam PF07840 FadR_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Fatty acid metabolism regulator protein {ECO:0000255|HAMAP-Rule MF_00696} # RefSeq NP_415705 NC_000913.3 # RefSeq WP_000234823 NZ_LN832404.1 # SIMILARITY Contains 1 HTH gntR-type DNA-binding domain. {ECO:0000255|HAMAP-Rule MF_00696}. # SMART SM00345 HTH_GNTR # SUBCELLULAR LOCATION FADR_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00696}. # SUBUNIT FADR_ECOLI Homodimer (PubMed 9388199, PubMed 11013219, PubMed 11296236, PubMed 11279025). Binding of acyl-CoA alters conformation of the dimer, separating the DNA-binding regions and disrupting DNA-binding (PubMed 11296236). {ECO 0000269|PubMed 11013219, ECO 0000269|PubMed 11279025, ECO 0000269|PubMed 11296236, ECO 0000269|PubMed 9388199}. # SUPFAM SSF46785 SSF46785 # SUPFAM SSF48008 SSF48008 # TIGRFAMs TIGR02812 fadR_gamma # eggNOG COG2186 LUCA # eggNOG ENOG4105C05 Bacteria BLAST swissprot:FADR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FADR_ECOLI BioCyc ECOL316407:JW1176-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1176-MONOMER BioCyc EcoCyc:PD01520 http://biocyc.org/getid?id=EcoCyc:PD01520 COG COG2186 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2186 DIP DIP-9564N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9564N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.270.3.1092 http://dx.doi.org/10.1074/jbc.270.3.1092 DOI 10.1074/jbc.272.49.30645 http://dx.doi.org/10.1074/jbc.272.49.30645 DOI 10.1074/jbc.M100195200 http://dx.doi.org/10.1074/jbc.M100195200 DOI 10.1074/jbc.M109.068239 http://dx.doi.org/10.1074/jbc.M109.068239 DOI 10.1074/jbc.M201399200 http://dx.doi.org/10.1074/jbc.M201399200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/emboj/19.19.5167 http://dx.doi.org/10.1093/emboj/19.19.5167 DOI 10.1093/emboj/20.8.2041 http://dx.doi.org/10.1093/emboj/20.8.2041 DOI 10.1093/nar/16.16.7995 http://dx.doi.org/10.1093/nar/16.16.7995 DOI 10.1111/j.1365-2958.1993.tb01122.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb01122.x DOI 10.1111/j.1365-2958.2011.07564.x http://dx.doi.org/10.1111/j.1365-2958.2011.07564.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X08087 http://www.ebi.ac.uk/ena/data/view/X08087 EchoBASE EB0277 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0277 EcoGene EG10281 http://www.ecogene.org/geneInfo.php?eg_id=EG10281 EnsemblBacteria AAC74271 http://www.ensemblgenomes.org/id/AAC74271 EnsemblBacteria AAC74271 http://www.ensemblgenomes.org/id/AAC74271 EnsemblBacteria BAA36042 http://www.ensemblgenomes.org/id/BAA36042 EnsemblBacteria BAA36042 http://www.ensemblgenomes.org/id/BAA36042 EnsemblBacteria BAA36042 http://www.ensemblgenomes.org/id/BAA36042 EnsemblBacteria b1187 http://www.ensemblgenomes.org/id/b1187 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000062 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000062 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0019217 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019217 GO_process GO:0019395 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019395 GO_process GO:0045723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045723 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 1.20.120.530 http://www.cathdb.info/version/latest/superfamily/1.20.120.530 GeneID 948652 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948652 HAMAP MF_00696 http://hamap.expasy.org/unirule/MF_00696 HOGENOM HOG000278467 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278467&db=HOGENOM6 InParanoid P0A8V6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8V6 IntAct P0A8V6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8V6* InterPro IPR000524 http://www.ebi.ac.uk/interpro/entry/IPR000524 InterPro IPR008920 http://www.ebi.ac.uk/interpro/entry/IPR008920 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR014178 http://www.ebi.ac.uk/interpro/entry/IPR014178 InterPro IPR028374 http://www.ebi.ac.uk/interpro/entry/IPR028374 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW1176 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1176 KEGG_Gene eco:b1187 http://www.genome.jp/dbget-bin/www_bget?eco:b1187 KEGG_Orthology KO:K03603 http://www.genome.jp/dbget-bin/www_bget?KO:K03603 MINT MINT-1264978 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1264978 OMA IWETSGL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IWETSGL PDB 1E2X http://www.ebi.ac.uk/pdbe-srv/view/entry/1E2X PDB 1H9G http://www.ebi.ac.uk/pdbe-srv/view/entry/1H9G PDB 1H9T http://www.ebi.ac.uk/pdbe-srv/view/entry/1H9T PDB 1HW1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1HW1 PDB 1HW2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1HW2 PDBsum 1E2X http://www.ebi.ac.uk/pdbsum/1E2X PDBsum 1H9G http://www.ebi.ac.uk/pdbsum/1H9G PDBsum 1H9T http://www.ebi.ac.uk/pdbsum/1H9T PDBsum 1HW1 http://www.ebi.ac.uk/pdbsum/1HW1 PDBsum 1HW2 http://www.ebi.ac.uk/pdbsum/1HW2 PRINTS PR00035 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00035 PROSITE PS50949 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50949 PSORT swissprot:FADR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FADR_ECOLI PSORT-B swissprot:FADR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FADR_ECOLI PSORT2 swissprot:FADR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FADR_ECOLI Pfam PF00392 http://pfam.xfam.org/family/PF00392 Pfam PF07840 http://pfam.xfam.org/family/PF07840 Phobius swissprot:FADR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FADR_ECOLI PhylomeDB P0A8V6 http://phylomedb.org/?seqid=P0A8V6 ProteinModelPortal P0A8V6 http://www.proteinmodelportal.org/query/uniprot/P0A8V6 PubMed 11013219 http://www.ncbi.nlm.nih.gov/pubmed/11013219 PubMed 11279025 http://www.ncbi.nlm.nih.gov/pubmed/11279025 PubMed 11296236 http://www.ncbi.nlm.nih.gov/pubmed/11296236 PubMed 11859088 http://www.ncbi.nlm.nih.gov/pubmed/11859088 PubMed 1569108 http://www.ncbi.nlm.nih.gov/pubmed/1569108 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19854834 http://www.ncbi.nlm.nih.gov/pubmed/19854834 PubMed 21276098 http://www.ncbi.nlm.nih.gov/pubmed/21276098 PubMed 2843809 http://www.ncbi.nlm.nih.gov/pubmed/2843809 PubMed 7836365 http://www.ncbi.nlm.nih.gov/pubmed/7836365 PubMed 8446033 http://www.ncbi.nlm.nih.gov/pubmed/8446033 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9388199 http://www.ncbi.nlm.nih.gov/pubmed/9388199 RefSeq NP_415705 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415705 RefSeq WP_000234823 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000234823 SMART SM00345 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00345 SMR P0A8V6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8V6 STRING 511145.b1187 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1187&targetmode=cogs STRING COG2186 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2186&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SUPFAM SSF48008 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48008 TIGRFAMs TIGR02812 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02812 UniProtKB FADR_ECOLI http://www.uniprot.org/uniprot/FADR_ECOLI UniProtKB-AC P0A8V6 http://www.uniprot.org/uniprot/P0A8V6 charge swissprot:FADR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FADR_ECOLI eggNOG COG2186 http://eggnogapi.embl.de/nog_data/html/tree/COG2186 eggNOG ENOG4105C05 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C05 epestfind swissprot:FADR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FADR_ECOLI garnier swissprot:FADR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FADR_ECOLI helixturnhelix swissprot:FADR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FADR_ECOLI hmoment swissprot:FADR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FADR_ECOLI iep swissprot:FADR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FADR_ECOLI inforesidue swissprot:FADR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FADR_ECOLI octanol swissprot:FADR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FADR_ECOLI pepcoil swissprot:FADR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FADR_ECOLI pepdigest swissprot:FADR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FADR_ECOLI pepinfo swissprot:FADR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FADR_ECOLI pepnet swissprot:FADR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FADR_ECOLI pepstats swissprot:FADR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FADR_ECOLI pepwheel swissprot:FADR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FADR_ECOLI pepwindow swissprot:FADR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FADR_ECOLI sigcleave swissprot:FADR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FADR_ECOLI ## Database ID URL or Descriptions # BioGrid 4260386 5 # CDD cd00383 trans_reg_C # EcoGene EG14045 yedW # FUNCTION YEDW_ECOLI Probable member of a two-component regulatory system YedW/YedV. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0000160 phosphorelay signal transduction system; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; ISS:EcoCyc. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # IntAct P76340 2 # InterPro IPR001789 Sig_transdc_resp-reg_receiver # InterPro IPR001867 OmpR/PhoB-type_DNA-bd # InterPro IPR006291 PcoR # InterPro IPR011006 CheY-like_superfamily # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR016032 Sig_transdc_resp-reg_C-effctor # KEGG_Brite ko02022 Two-component system # Organism YEDW_ECOLI Escherichia coli (strain K12) # PATRIC 32119269 VBIEscCol129921_2049 # PIR E64961 E64961 # PROSITE PS50110 RESPONSE_REGULATORY # PROSITE PS51755 OMPR_PHOB # PTM YEDW_ECOLI Phosphorylated by YedV. {ECO 0000269|PubMed 15522865}. # Pfam PF00072 Response_reg # Pfam PF00486 Trans_reg_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEDW_ECOLI Probable transcriptional regulatory protein YedW # RefSeq NP_416478 NC_000913.3 # RefSeq WP_001395354 NZ_LN832404.1 # SIMILARITY Contains 1 OmpR/PhoB-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU01091}. # SIMILARITY Contains 1 response regulatory domain. {ECO:0000255|PROSITE-ProRule PRU00169}. # SMART SM00448 REC # SMART SM00862 Trans_reg_C # SUBCELLULAR LOCATION YEDW_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF46894 SSF46894 # SUPFAM SSF52172 SSF52172 # TIGRFAMs TIGR01387 cztR_silR_copR # eggNOG COG0745 LUCA # eggNOG ENOG4105CK6 Bacteria BLAST swissprot:YEDW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEDW_ECOLI BioCyc ECOL316407:JW5322-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5322-MONOMER BioCyc EcoCyc:G7057-MONOMER http://biocyc.org/getid?id=EcoCyc:G7057-MONOMER COG COG0745 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0745 DIP DIP-11853N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11853N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M410104200 http://dx.doi.org/10.1074/jbc.M410104200 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3798 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3798 EcoGene EG14045 http://www.ecogene.org/geneInfo.php?eg_id=EG14045 EnsemblBacteria AAC75035 http://www.ensemblgenomes.org/id/AAC75035 EnsemblBacteria AAC75035 http://www.ensemblgenomes.org/id/AAC75035 EnsemblBacteria BAA15796 http://www.ensemblgenomes.org/id/BAA15796 EnsemblBacteria BAA15796 http://www.ensemblgenomes.org/id/BAA15796 EnsemblBacteria BAA15796 http://www.ensemblgenomes.org/id/BAA15796 EnsemblBacteria b1969 http://www.ensemblgenomes.org/id/b1969 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 946486 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946486 HOGENOM HOG000034815 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000034815&db=HOGENOM6 InParanoid P76340 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76340 IntAct P76340 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76340* InterPro IPR001789 http://www.ebi.ac.uk/interpro/entry/IPR001789 InterPro IPR001867 http://www.ebi.ac.uk/interpro/entry/IPR001867 InterPro IPR006291 http://www.ebi.ac.uk/interpro/entry/IPR006291 InterPro IPR011006 http://www.ebi.ac.uk/interpro/entry/IPR011006 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR016032 http://www.ebi.ac.uk/interpro/entry/IPR016032 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW5322 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5322 KEGG_Gene eco:b1969 http://www.genome.jp/dbget-bin/www_bget?eco:b1969 KEGG_Orthology KO:K02483 http://www.genome.jp/dbget-bin/www_bget?KO:K02483 MINT MINT-1223015 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1223015 OMA CDVIQTV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CDVIQTV PROSITE PS50110 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50110 PROSITE PS51755 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51755 PSORT swissprot:YEDW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEDW_ECOLI PSORT-B swissprot:YEDW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEDW_ECOLI PSORT2 swissprot:YEDW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEDW_ECOLI Pfam PF00072 http://pfam.xfam.org/family/PF00072 Pfam PF00486 http://pfam.xfam.org/family/PF00486 Phobius swissprot:YEDW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEDW_ECOLI PhylomeDB P76340 http://phylomedb.org/?seqid=P76340 ProteinModelPortal P76340 http://www.proteinmodelportal.org/query/uniprot/P76340 PubMed 15522865 http://www.ncbi.nlm.nih.gov/pubmed/15522865 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416478 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416478 RefSeq WP_001395354 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001395354 SMART SM00448 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00448 SMART SM00862 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00862 SMR P76340 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76340 STRING 511145.b1969 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1969&targetmode=cogs STRING COG0745 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0745&targetmode=cogs SUPFAM SSF46894 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46894 SUPFAM SSF52172 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52172 TIGRFAMs TIGR01387 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01387 UniProtKB YEDW_ECOLI http://www.uniprot.org/uniprot/YEDW_ECOLI UniProtKB-AC P76340 http://www.uniprot.org/uniprot/P76340 charge swissprot:YEDW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEDW_ECOLI eggNOG COG0745 http://eggnogapi.embl.de/nog_data/html/tree/COG0745 eggNOG ENOG4105CK6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CK6 epestfind swissprot:YEDW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEDW_ECOLI garnier swissprot:YEDW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEDW_ECOLI helixturnhelix swissprot:YEDW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEDW_ECOLI hmoment swissprot:YEDW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEDW_ECOLI iep swissprot:YEDW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEDW_ECOLI inforesidue swissprot:YEDW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEDW_ECOLI octanol swissprot:YEDW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEDW_ECOLI pepcoil swissprot:YEDW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEDW_ECOLI pepdigest swissprot:YEDW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEDW_ECOLI pepinfo swissprot:YEDW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEDW_ECOLI pepnet swissprot:YEDW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEDW_ECOLI pepstats swissprot:YEDW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEDW_ECOLI pepwheel swissprot:YEDW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEDW_ECOLI pepwindow swissprot:YEDW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEDW_ECOLI sigcleave swissprot:YEDW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEDW_ECOLI ## Database ID URL or Descriptions # BioGrid 4263485 7 # CDD cd06170 LuxR_C_like # EcoGene EG11527 narP # FUNCTION NARP_ECOLI This protein activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal transmitted by either the NarX or NarQ proteins. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_function GO:0003677 DNA binding; IMP:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0000160 phosphorelay signal transduction system; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IMP:EcoCyc. # GO_process GO:0042128 nitrate assimilation; IEA:UniProtKB-KW. # GOslim_component GO:0005622 intracellular # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0071941 nitrogen cycle metabolic process # Gene3D 1.10.10.10 -; 1. # IntAct P31802 5 # InterPro IPR000792 Tscrpt_reg_LuxR_C # InterPro IPR001789 Sig_transdc_resp-reg_receiver # InterPro IPR011006 CheY-like_superfamily # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR016032 Sig_transdc_resp-reg_C-effctor # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02022 M00472 NarQ-NarP (nitrate respiration) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # Organism NARP_ECOLI Escherichia coli (strain K12) # PATRIC 32119745 VBIEscCol129921_2282 # PIR A40584 A40584 # PRINTS PR00038 HTHLUXR # PROSITE PS00622 HTH_LUXR_1 # PROSITE PS50043 HTH_LUXR_2 # PROSITE PS50110 RESPONSE_REGULATORY # Pfam PF00072 Response_reg # Pfam PF00196 GerE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NARP_ECOLI Nitrate/nitrite response regulator protein NarP # RefSeq NP_416697 NC_000913.3 # RefSeq WP_001113639 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA16411.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Contains 1 HTH luxR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00411}. # SIMILARITY Contains 1 response regulatory domain. {ECO:0000255|PROSITE-ProRule PRU00169}. # SMART SM00421 HTH_LUXR # SMART SM00448 REC # SUPFAM SSF46894 SSF46894 # SUPFAM SSF52172 SSF52172 # eggNOG COG2197 LUCA # eggNOG ENOG4105WH1 Bacteria BLAST swissprot:NARP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NARP_ECOLI BioCyc ECOL316407:JW2181-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2181-MONOMER BioCyc EcoCyc:NARP-MONOMER http://biocyc.org/getid?id=EcoCyc:NARP-MONOMER COG COG2197 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2197 DIP DIP-10317N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10317N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L11273 http://www.ebi.ac.uk/ena/data/view/L11273 EMBL U00008 http://www.ebi.ac.uk/ena/data/view/U00008 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1489 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1489 EcoGene EG11527 http://www.ecogene.org/geneInfo.php?eg_id=EG11527 EnsemblBacteria AAC75253 http://www.ensemblgenomes.org/id/AAC75253 EnsemblBacteria AAC75253 http://www.ensemblgenomes.org/id/AAC75253 EnsemblBacteria BAE76656 http://www.ensemblgenomes.org/id/BAE76656 EnsemblBacteria BAE76656 http://www.ensemblgenomes.org/id/BAE76656 EnsemblBacteria BAE76656 http://www.ensemblgenomes.org/id/BAE76656 EnsemblBacteria b2193 http://www.ensemblgenomes.org/id/b2193 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0042128 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042128 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0071941 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071941 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 949081 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949081 HOGENOM HOG000034813 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000034813&db=HOGENOM6 InParanoid P31802 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31802 IntAct P31802 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31802* InterPro IPR000792 http://www.ebi.ac.uk/interpro/entry/IPR000792 InterPro IPR001789 http://www.ebi.ac.uk/interpro/entry/IPR001789 InterPro IPR011006 http://www.ebi.ac.uk/interpro/entry/IPR011006 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR016032 http://www.ebi.ac.uk/interpro/entry/IPR016032 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW2181 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2181 KEGG_Gene eco:b2193 http://www.genome.jp/dbget-bin/www_bget?eco:b2193 KEGG_Orthology KO:K07685 http://www.genome.jp/dbget-bin/www_bget?KO:K07685 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA QISPSMA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QISPSMA PRINTS PR00038 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00038 PROSITE PS00622 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00622 PROSITE PS50043 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50043 PROSITE PS50110 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50110 PSORT swissprot:NARP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NARP_ECOLI PSORT-B swissprot:NARP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NARP_ECOLI PSORT2 swissprot:NARP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NARP_ECOLI Pfam PF00072 http://pfam.xfam.org/family/PF00072 Pfam PF00196 http://pfam.xfam.org/family/PF00196 Phobius swissprot:NARP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NARP_ECOLI PhylomeDB P31802 http://phylomedb.org/?seqid=P31802 ProteinModelPortal P31802 http://www.proteinmodelportal.org/query/uniprot/P31802 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8501030 http://www.ncbi.nlm.nih.gov/pubmed/8501030 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416697 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416697 RefSeq WP_001113639 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001113639 SMART SM00421 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00421 SMART SM00448 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00448 SMR P31802 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31802 STRING 511145.b2193 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2193&targetmode=cogs STRING COG2197 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2197&targetmode=cogs SUPFAM SSF46894 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46894 SUPFAM SSF52172 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52172 UniProtKB NARP_ECOLI http://www.uniprot.org/uniprot/NARP_ECOLI UniProtKB-AC P31802 http://www.uniprot.org/uniprot/P31802 charge swissprot:NARP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NARP_ECOLI eggNOG COG2197 http://eggnogapi.embl.de/nog_data/html/tree/COG2197 eggNOG ENOG4105WH1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105WH1 epestfind swissprot:NARP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NARP_ECOLI garnier swissprot:NARP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NARP_ECOLI helixturnhelix swissprot:NARP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NARP_ECOLI hmoment swissprot:NARP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NARP_ECOLI iep swissprot:NARP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NARP_ECOLI inforesidue swissprot:NARP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NARP_ECOLI octanol swissprot:NARP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NARP_ECOLI pepcoil swissprot:NARP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NARP_ECOLI pepdigest swissprot:NARP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NARP_ECOLI pepinfo swissprot:NARP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NARP_ECOLI pepnet swissprot:NARP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NARP_ECOLI pepstats swissprot:NARP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NARP_ECOLI pepwheel swissprot:NARP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NARP_ECOLI pepwindow swissprot:NARP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NARP_ECOLI sigcleave swissprot:NARP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NARP_ECOLI ## Database ID URL or Descriptions # FUNCTION TRAU_ECOLI Appears to be more essential to conjugal DNA transfer than to assembly of pilus filaments. Required for F plasmid conjugative transfer. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_process GO:0000746 conjugation; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0008150 biological_process # InterPro IPR009649 TraU # MISCELLANEOUS TRAU_ECOLI May be part of a periplasmic complex containing other proteins. # Organism TRAU_ECOLI Escherichia coli (strain K12) # PIR B37756 B37756 # Pfam PF06834 TraU # RecName TRAU_ECOLI Protein TraU # RefSeq NP_061466 NC_002483.1 # RefSeq WP_000830185 NZ_CP014273.1 # SUBCELLULAR LOCATION TRAU_ECOLI Periplasm. BLAST swissprot:TRAU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRAU_ECOLI DIP DIP-28102N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-28102N EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL M34695 http://www.ebi.ac.uk/ena/data/view/M34695 EMBL M60427 http://www.ebi.ac.uk/ena/data/view/M60427 EMBL M93106 http://www.ebi.ac.uk/ena/data/view/M93106 EMBL U01159 http://www.ebi.ac.uk/ena/data/view/U01159 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_process GO:0000746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000746 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 1263544 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263544 InterPro IPR009649 http://www.ebi.ac.uk/interpro/entry/IPR009649 OMA DVAYMTE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DVAYMTE PSORT swissprot:TRAU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRAU_ECOLI PSORT-B swissprot:TRAU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRAU_ECOLI PSORT2 swissprot:TRAU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRAU_ECOLI Pfam PF06834 http://pfam.xfam.org/family/PF06834 Phobius swissprot:TRAU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRAU_ECOLI ProteinModelPortal P18471 http://www.proteinmodelportal.org/query/uniprot/P18471 PubMed 1355084 http://www.ncbi.nlm.nih.gov/pubmed/1355084 PubMed 2050638 http://www.ncbi.nlm.nih.gov/pubmed/2050638 PubMed 2198250 http://www.ncbi.nlm.nih.gov/pubmed/2198250 PubMed 7915817 http://www.ncbi.nlm.nih.gov/pubmed/7915817 RefSeq NP_061466 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061466 RefSeq WP_000830185 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000830185 UniProtKB TRAU_ECOLI http://www.uniprot.org/uniprot/TRAU_ECOLI UniProtKB-AC P18471 http://www.uniprot.org/uniprot/P18471 charge swissprot:TRAU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRAU_ECOLI epestfind swissprot:TRAU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRAU_ECOLI garnier swissprot:TRAU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRAU_ECOLI helixturnhelix swissprot:TRAU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRAU_ECOLI hmoment swissprot:TRAU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRAU_ECOLI iep swissprot:TRAU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRAU_ECOLI inforesidue swissprot:TRAU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRAU_ECOLI octanol swissprot:TRAU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRAU_ECOLI pepcoil swissprot:TRAU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRAU_ECOLI pepdigest swissprot:TRAU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRAU_ECOLI pepinfo swissprot:TRAU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRAU_ECOLI pepnet swissprot:TRAU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRAU_ECOLI pepstats swissprot:TRAU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRAU_ECOLI pepwheel swissprot:TRAU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRAU_ECOLI pepwindow swissprot:TRAU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRAU_ECOLI sigcleave swissprot:TRAU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRAU_ECOLI ## Database ID URL or Descriptions # BioGrid 4262153 7 # COFACTOR HYFI_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000305}; Note=Binds 1 [4Fe-4S] cluster. {ECO 0000305}; # EcoGene EG14217 hyfI # GO_function GO:0008137 NADH dehydrogenase (ubiquinone) activity; ISS:EcoliWiki. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0048038 quinone binding; IEA:InterPro. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.700 -; 1. # InterPro IPR006137 NADH_UbQ_OxRdtase-like_20kDa # InterPro IPR006138 NADH_UQ_OxRdtase_20Kd_su # KEGG_Brite ko01000 Enzymes # Organism HYFI_ECOLI Escherichia coli (strain K12) # PATRIC 32120365 VBIEscCol129921_2585 # PIR H65024 H65024 # PROSITE PS01150 COMPLEX1_20K # Pfam PF01058 Oxidored_q6 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HYFI_ECOLI Hydrogenase-4 component I # RefSeq NP_416984 NC_000913.3 # RefSeq WP_000075558 NZ_LN832404.1 # SIMILARITY Belongs to the complex I 20 kDa subunit family. {ECO 0000305}. # TCDB 3.D.1.9 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family # eggNOG COG3260 LUCA # eggNOG ENOG4105C47 Bacteria BLAST swissprot:HYFI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HYFI_ECOLI BioCyc ECOL316407:JW5805-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5805-MONOMER BioCyc EcoCyc:MONOMER0-151 http://biocyc.org/getid?id=EcoCyc:MONOMER0-151 COG COG3260 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3260 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M63654 http://www.ebi.ac.uk/ena/data/view/M63654 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- EchoBASE EB3969 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3969 EcoGene EG14217 http://www.ecogene.org/geneInfo.php?eg_id=EG14217 EnsemblBacteria AAC75542 http://www.ensemblgenomes.org/id/AAC75542 EnsemblBacteria AAC75542 http://www.ensemblgenomes.org/id/AAC75542 EnsemblBacteria BAA16377 http://www.ensemblgenomes.org/id/BAA16377 EnsemblBacteria BAA16377 http://www.ensemblgenomes.org/id/BAA16377 EnsemblBacteria BAA16377 http://www.ensemblgenomes.org/id/BAA16377 EnsemblBacteria b2489 http://www.ensemblgenomes.org/id/b2489 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008137 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008137 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0048038 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048038 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.700 http://www.cathdb.info/version/latest/superfamily/3.40.50.700 GeneID 946966 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946966 HOGENOM HOG000228250 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000228250&db=HOGENOM6 InParanoid P77668 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77668 IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR006137 http://www.ebi.ac.uk/interpro/entry/IPR006137 InterPro IPR006138 http://www.ebi.ac.uk/interpro/entry/IPR006138 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5805 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5805 KEGG_Gene eco:b2489 http://www.genome.jp/dbget-bin/www_bget?eco:b2489 KEGG_Orthology KO:K12144 http://www.genome.jp/dbget-bin/www_bget?KO:K12144 OMA LRIYHAM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LRIYHAM PROSITE PS01150 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01150 PSORT swissprot:HYFI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HYFI_ECOLI PSORT-B swissprot:HYFI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HYFI_ECOLI PSORT2 swissprot:HYFI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HYFI_ECOLI Pfam PF01058 http://pfam.xfam.org/family/PF01058 Phobius swissprot:HYFI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HYFI_ECOLI PhylomeDB P77668 http://phylomedb.org/?seqid=P77668 ProteinModelPortal P77668 http://www.proteinmodelportal.org/query/uniprot/P77668 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416984 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416984 RefSeq WP_000075558 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000075558 SMR P77668 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77668 STRING 511145.b2489 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2489&targetmode=cogs STRING COG3260 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3260&targetmode=cogs TCDB 3.D.1.9 http://www.tcdb.org/search/result.php?tc=3.D.1.9 UniProtKB HYFI_ECOLI http://www.uniprot.org/uniprot/HYFI_ECOLI UniProtKB-AC P77668 http://www.uniprot.org/uniprot/P77668 charge swissprot:HYFI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HYFI_ECOLI eggNOG COG3260 http://eggnogapi.embl.de/nog_data/html/tree/COG3260 eggNOG ENOG4105C47 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C47 epestfind swissprot:HYFI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HYFI_ECOLI garnier swissprot:HYFI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HYFI_ECOLI helixturnhelix swissprot:HYFI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HYFI_ECOLI hmoment swissprot:HYFI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HYFI_ECOLI iep swissprot:HYFI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HYFI_ECOLI inforesidue swissprot:HYFI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HYFI_ECOLI octanol swissprot:HYFI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HYFI_ECOLI pepcoil swissprot:HYFI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HYFI_ECOLI pepdigest swissprot:HYFI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HYFI_ECOLI pepinfo swissprot:HYFI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HYFI_ECOLI pepnet swissprot:HYFI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HYFI_ECOLI pepstats swissprot:HYFI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HYFI_ECOLI pepwheel swissprot:HYFI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HYFI_ECOLI pepwindow swissprot:HYFI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HYFI_ECOLI sigcleave swissprot:HYFI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HYFI_ECOLI ## Database ID URL or Descriptions # AltName BGLR_ECOLI Beta-D-glucuronoside glucuronosohydrolase # BIOPHYSICOCHEMICAL PROPERTIES pH dependence: Optimum pH is 5.0-7.5.; Temperature dependence Resistant to thermal inactivation at 50 degrees Celsius.; # BRENDA 3.2.1.31 2026 # BioGrid 4263483 11 # CATALYTIC ACTIVITY BGLR_ECOLI A beta-D-glucuronoside + H(2)O = D-glucuronate + an alcohol. # CAZy GH2 Glycoside Hydrolase Family 2 # EcoGene EG11055 uidA # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0043231 intracellular membrane-bounded organelle; IBA:GO_Central. # GO_function GO:0004566 beta-glucuronidase activity; IDA:EcoCyc. # GO_process GO:0019391 glucuronoside catabolic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_component GO:0043226 organelle # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 2.60.120.260 -; 1. # Gene3D 2.60.40.320 -; 1. # Gene3D 3.20.20.80 -; 1. # IntAct P05804 2 # InterPro IPR006101 Glyco_hydro_2 # InterPro IPR006102 Glyco_hydro_2_Ig-like # InterPro IPR006103 Glyco_hydro_2_cat # InterPro IPR006104 Glyco_hydro_2_N # InterPro IPR008979 Galactose-bd-like # InterPro IPR013781 Glyco_hydro_catalytic_dom # InterPro IPR013812 Glyco_hydro_2/20_Ig-like # InterPro IPR017853 Glycoside_hydrolase_SF # InterPro IPR023230 Glyco_hydro_2_CS # InterPro IPR023232 Glyco_hydro_2_AS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00040 Pentose and glucuronate interconversions # KEGG_Pathway ko00500 Starch and sucrose metabolism # KEGG_Pathway ko00531 Glycosaminoglycan degradation # KEGG_Pathway ko00860 Porphyrin and chlorophyll metabolism # KEGG_Pathway ko00944 Flavone and flavonol biosynthesis # KEGG_Pathway ko00983 Drug metabolism - other enzymes # KEGG_Pathway ko04142 Lysosome # MISCELLANEOUS BGLR_ECOLI Substrates for this enzyme are generally water- soluble. # Organism BGLR_ECOLI Escherichia coli (strain K12) # PATRIC 32118536 VBIEscCol129921_1688 # PDB 3K46 X-ray; 2.50 A; A/B=1-603 # PDB 3K4A X-ray; 2.90 A; A/B=1-603 # PDB 3K4D X-ray; 2.39 A; A/B=1-603 # PDB 3LPF X-ray; 2.26 A; A/B=1-603 # PDB 3LPG X-ray; 2.42 A; A/B=1-603 # PDB 4JHZ X-ray; 2.83 A; A/B=1-601 # PDB 5CZK X-ray; 2.39 A; A/B=1-603 # PIR C64918 GBECGC # PRINTS PR00132 GLHYDRLASE2 # PROSITE PS00608 GLYCOSYL_HYDROL_F2_2 # PROSITE PS00719 GLYCOSYL_HYDROL_F2_1 # Pfam PF00703 Glyco_hydro_2 # Pfam PF02836 Glyco_hydro_2_C # Pfam PF02837 Glyco_hydro_2_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BGLR_ECOLI Beta-glucuronidase # RefSeq NP_416134 NC_000913.3 # RefSeq WP_000945878 NZ_LN832404.1 # SIMILARITY Belongs to the glycosyl hydrolase 2 family. {ECO 0000305}. # SUBUNIT Homotetramer. {ECO:0000269|PubMed 3105604}. # SUPFAM SSF49303 SSF49303 # SUPFAM SSF49785 SSF49785 # SUPFAM SSF51445 SSF51445 # eggNOG COG3250 LUCA # eggNOG ENOG4105CNT Bacteria BLAST swissprot:BGLR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BGLR_ECOLI BioCyc ECOL316407:JW1609-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1609-MONOMER BioCyc EcoCyc:BETA-GLUCURONID-MONOMER http://biocyc.org/getid?id=EcoCyc:BETA-GLUCURONID-MONOMER BioCyc MetaCyc:BETA-GLUCURONID-MONOMER http://biocyc.org/getid?id=MetaCyc:BETA-GLUCURONID-MONOMER COG COG3250 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3250 DIP DIP-11086N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11086N DOI 10.1007/BF00039422 http://dx.doi.org/10.1007/BF00039422 DOI 10.1016/0300-9084(87)90248-3 http://dx.doi.org/10.1016/0300-9084(87)90248-3 DOI 10.1016/0378-1119(94)90820-6 http://dx.doi.org/10.1016/0378-1119(94)90820-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.83.22.8447 http://dx.doi.org/10.1073/pnas.83.22.8447 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.2.1.31 http://www.genome.jp/dbget-bin/www_bget?EC:3.2.1.31 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M14641 http://www.ebi.ac.uk/ena/data/view/M14641 EMBL S69414 http://www.ebi.ac.uk/ena/data/view/S69414 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.2.1.31 http://enzyme.expasy.org/EC/3.2.1.31 EchoBASE EB1048 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1048 EcoGene EG11055 http://www.ecogene.org/geneInfo.php?eg_id=EG11055 EnsemblBacteria AAC74689 http://www.ensemblgenomes.org/id/AAC74689 EnsemblBacteria AAC74689 http://www.ensemblgenomes.org/id/AAC74689 EnsemblBacteria BAA15368 http://www.ensemblgenomes.org/id/BAA15368 EnsemblBacteria BAA15368 http://www.ensemblgenomes.org/id/BAA15368 EnsemblBacteria BAA15368 http://www.ensemblgenomes.org/id/BAA15368 EnsemblBacteria b1617 http://www.ensemblgenomes.org/id/b1617 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0043231 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043231 GO_function GO:0004566 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004566 GO_process GO:0019391 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019391 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0043226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043226 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 2.60.120.260 http://www.cathdb.info/version/latest/superfamily/2.60.120.260 Gene3D 2.60.40.320 http://www.cathdb.info/version/latest/superfamily/2.60.40.320 Gene3D 3.20.20.80 http://www.cathdb.info/version/latest/superfamily/3.20.20.80 GeneID 946149 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946149 HOGENOM HOG000120896 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120896&db=HOGENOM6 InParanoid P05804 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P05804 IntAct P05804 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P05804* IntEnz 3.2.1.31 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.2.1.31 InterPro IPR006101 http://www.ebi.ac.uk/interpro/entry/IPR006101 InterPro IPR006102 http://www.ebi.ac.uk/interpro/entry/IPR006102 InterPro IPR006103 http://www.ebi.ac.uk/interpro/entry/IPR006103 InterPro IPR006104 http://www.ebi.ac.uk/interpro/entry/IPR006104 InterPro IPR008979 http://www.ebi.ac.uk/interpro/entry/IPR008979 InterPro IPR013781 http://www.ebi.ac.uk/interpro/entry/IPR013781 InterPro IPR013812 http://www.ebi.ac.uk/interpro/entry/IPR013812 InterPro IPR017853 http://www.ebi.ac.uk/interpro/entry/IPR017853 InterPro IPR023230 http://www.ebi.ac.uk/interpro/entry/IPR023230 InterPro IPR023232 http://www.ebi.ac.uk/interpro/entry/IPR023232 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1609 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1609 KEGG_Gene eco:b1617 http://www.genome.jp/dbget-bin/www_bget?eco:b1617 KEGG_Orthology KO:K01195 http://www.genome.jp/dbget-bin/www_bget?KO:K01195 KEGG_Pathway ko00040 http://www.genome.jp/kegg-bin/show_pathway?ko00040 KEGG_Pathway ko00500 http://www.genome.jp/kegg-bin/show_pathway?ko00500 KEGG_Pathway ko00531 http://www.genome.jp/kegg-bin/show_pathway?ko00531 KEGG_Pathway ko00860 http://www.genome.jp/kegg-bin/show_pathway?ko00860 KEGG_Pathway ko00944 http://www.genome.jp/kegg-bin/show_pathway?ko00944 KEGG_Pathway ko00983 http://www.genome.jp/kegg-bin/show_pathway?ko00983 KEGG_Pathway ko04142 http://www.genome.jp/kegg-bin/show_pathway?ko04142 KEGG_Reaction rn:R01478 http://www.genome.jp/dbget-bin/www_bget?rn:R01478 KEGG_Reaction rn:R04979 http://www.genome.jp/dbget-bin/www_bget?rn:R04979 KEGG_Reaction rn:R07818 http://www.genome.jp/dbget-bin/www_bget?rn:R07818 KEGG_Reaction rn:R08127 http://www.genome.jp/dbget-bin/www_bget?rn:R08127 KEGG_Reaction rn:R08260 http://www.genome.jp/dbget-bin/www_bget?rn:R08260 OMA YTTPRTF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YTTPRTF PDB 3K46 http://www.ebi.ac.uk/pdbe-srv/view/entry/3K46 PDB 3K4A http://www.ebi.ac.uk/pdbe-srv/view/entry/3K4A PDB 3K4D http://www.ebi.ac.uk/pdbe-srv/view/entry/3K4D PDB 3LPF http://www.ebi.ac.uk/pdbe-srv/view/entry/3LPF PDB 3LPG http://www.ebi.ac.uk/pdbe-srv/view/entry/3LPG PDB 4JHZ http://www.ebi.ac.uk/pdbe-srv/view/entry/4JHZ PDB 5CZK http://www.ebi.ac.uk/pdbe-srv/view/entry/5CZK PDBsum 3K46 http://www.ebi.ac.uk/pdbsum/3K46 PDBsum 3K4A http://www.ebi.ac.uk/pdbsum/3K4A PDBsum 3K4D http://www.ebi.ac.uk/pdbsum/3K4D PDBsum 3LPF http://www.ebi.ac.uk/pdbsum/3LPF PDBsum 3LPG http://www.ebi.ac.uk/pdbsum/3LPG PDBsum 4JHZ http://www.ebi.ac.uk/pdbsum/4JHZ PDBsum 5CZK http://www.ebi.ac.uk/pdbsum/5CZK PRINTS PR00132 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00132 PROSITE PS00608 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00608 PROSITE PS00719 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00719 PSORT swissprot:BGLR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BGLR_ECOLI PSORT-B swissprot:BGLR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BGLR_ECOLI PSORT2 swissprot:BGLR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BGLR_ECOLI Pfam PF00703 http://pfam.xfam.org/family/PF00703 Pfam PF02836 http://pfam.xfam.org/family/PF02836 Pfam PF02837 http://pfam.xfam.org/family/PF02837 Phobius swissprot:BGLR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BGLR_ECOLI PhylomeDB P05804 http://phylomedb.org/?seqid=P05804 ProteinModelPortal P05804 http://www.proteinmodelportal.org/query/uniprot/P05804 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2103475 http://www.ncbi.nlm.nih.gov/pubmed/2103475 PubMed 3105604 http://www.ncbi.nlm.nih.gov/pubmed/3105604 PubMed 3534890 http://www.ncbi.nlm.nih.gov/pubmed/3534890 PubMed 8125312 http://www.ncbi.nlm.nih.gov/pubmed/8125312 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416134 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416134 RefSeq WP_000945878 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000945878 SMR P05804 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P05804 STRING 511145.b1617 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1617&targetmode=cogs STRING COG3250 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3250&targetmode=cogs SUPFAM SSF49303 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49303 SUPFAM SSF49785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49785 SUPFAM SSF51445 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51445 UniProtKB BGLR_ECOLI http://www.uniprot.org/uniprot/BGLR_ECOLI UniProtKB-AC P05804 http://www.uniprot.org/uniprot/P05804 charge swissprot:BGLR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BGLR_ECOLI eggNOG COG3250 http://eggnogapi.embl.de/nog_data/html/tree/COG3250 eggNOG ENOG4105CNT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CNT epestfind swissprot:BGLR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BGLR_ECOLI garnier swissprot:BGLR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BGLR_ECOLI helixturnhelix swissprot:BGLR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BGLR_ECOLI hmoment swissprot:BGLR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BGLR_ECOLI iep swissprot:BGLR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BGLR_ECOLI inforesidue swissprot:BGLR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BGLR_ECOLI octanol swissprot:BGLR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BGLR_ECOLI pepcoil swissprot:BGLR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BGLR_ECOLI pepdigest swissprot:BGLR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BGLR_ECOLI pepinfo swissprot:BGLR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BGLR_ECOLI pepnet swissprot:BGLR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BGLR_ECOLI pepstats swissprot:BGLR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BGLR_ECOLI pepwheel swissprot:BGLR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BGLR_ECOLI pepwindow swissprot:BGLR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BGLR_ECOLI sigcleave swissprot:BGLR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BGLR_ECOLI ## Database ID URL or Descriptions # AltName MNMG_ECOLI Glucose-inhibited division protein A # BioGrid 4263258 136 # COFACTOR MNMG_ECOLI Name=FAD; Xref=ChEBI CHEBI 57692; Evidence={ECO 0000269|PubMed 17062623}; # EcoGene EG10375 mnmG # FUNCTION MNMG_ECOLI NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. {ECO 0000269|PubMed 11544186, ECO 0000269|PubMed 17062623, ECO 0000269|PubMed 9603884}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0016491 oxidoreductase activity; IEA:InterPro. # GO_function GO:0050660 flavin adenine dinucleotide binding; IDA:EcoCyc. # GO_process GO:0002098 tRNA wobble uridine modification; IDA:EcoCyc. # GO_process GO:0030488 tRNA methylation; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # Gene3D 3.50.50.60 -; 1. # HAMAP MF_00129 MnmG_GidA # INTERACTION MNMG_ECOLI P25522 mnmE; NbExp=4; IntAct=EBI-550977, EBI-550986; # IntAct P0A6U3 12 # InterPro IPR002218 MnmG-rel # InterPro IPR004416 MnmG # InterPro IPR020595 MnmG-rel_CS # InterPro IPR023753 FAD/NAD-binding_dom # InterPro IPR026904 GidA-assoc_3 # KEGG_Brite ko03016 Transfer RNA biogenesis # KEGG_Brite ko03036 Chromosome # Organism MNMG_ECOLI Escherichia coli (strain K12) # PATRIC 32122981 VBIEscCol129921_3866 # PDB 3CES X-ray; 2.41 A; A/B/C/D=1-629 # PDB 3CP2 X-ray; 2.90 A; A=1-629 # PIR F65177 BVECQA # PROSITE PS01280 GIDA_1 # PROSITE PS01281 GIDA_2 # Pfam PF01134 GIDA # Pfam PF13932 GIDA_assoc # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MNMG_ECOLI tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG # RefSeq NP_418197 NC_000913.3 # RefSeq WP_000499788 NZ_LN832404.1 # SIMILARITY Belongs to the MnmG family. {ECO 0000305}. # SUBCELLULAR LOCATION MNMG_ECOLI Cytoplasm {ECO 0000269|PubMed 17062623}. # SUBUNIT Homodimer. Heterotetramer of two MnmE and two MnmG subunits. {ECO:0000269|PubMed 18565343}. # SUPFAM SSF51905 SSF51905; 2 # TIGRFAMs TIGR00136 gidA # eggNOG COG0445 LUCA # eggNOG ENOG4107RE5 Bacteria BLAST swissprot:MNMG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MNMG_ECOLI BioCyc ECOL316407:JW3719-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3719-MONOMER BioCyc EcoCyc:EG10375-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10375-MONOMER BioCyc MetaCyc:EG10375-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10375-MONOMER COG COG0445 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0445 DIP DIP-35786N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35786N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1016/0378-1119(83)90087-2 http://dx.doi.org/10.1016/0378-1119(83)90087-2 DOI 10.1016/j.jmb.2008.04.072 http://dx.doi.org/10.1016/j.jmb.2008.04.072 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2240799 http://dx.doi.org/10.1042/bj2240799 DOI 10.1073/pnas.76.2.575 http://dx.doi.org/10.1073/pnas.76.2.575 DOI 10.1093/nar/gkl752 http://dx.doi.org/10.1093/nar/gkl752 DOI 10.1101/gad.207701 http://dx.doi.org/10.1101/gad.207701 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01657 http://www.ebi.ac.uk/ena/data/view/J01657 EMBL K00826 http://www.ebi.ac.uk/ena/data/view/K00826 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X01631 http://www.ebi.ac.uk/ena/data/view/X01631 EchoBASE EB0370 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0370 EcoGene EG10375 http://www.ecogene.org/geneInfo.php?eg_id=EG10375 EnsemblBacteria AAC76764 http://www.ensemblgenomes.org/id/AAC76764 EnsemblBacteria AAC76764 http://www.ensemblgenomes.org/id/AAC76764 EnsemblBacteria BAE77547 http://www.ensemblgenomes.org/id/BAE77547 EnsemblBacteria BAE77547 http://www.ensemblgenomes.org/id/BAE77547 EnsemblBacteria BAE77547 http://www.ensemblgenomes.org/id/BAE77547 EnsemblBacteria b3741 http://www.ensemblgenomes.org/id/b3741 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_process GO:0002098 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002098 GO_process GO:0030488 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030488 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 GeneID 948248 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948248 HAMAP MF_00129 http://hamap.expasy.org/unirule/MF_00129 HOGENOM HOG000201059 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000201059&db=HOGENOM6 InParanoid P0A6U3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6U3 IntAct P0A6U3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6U3* InterPro IPR002218 http://www.ebi.ac.uk/interpro/entry/IPR002218 InterPro IPR004416 http://www.ebi.ac.uk/interpro/entry/IPR004416 InterPro IPR020595 http://www.ebi.ac.uk/interpro/entry/IPR020595 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 InterPro IPR026904 http://www.ebi.ac.uk/interpro/entry/IPR026904 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene ecj:JW3719 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3719 KEGG_Gene eco:b3741 http://www.genome.jp/dbget-bin/www_bget?eco:b3741 KEGG_Orthology KO:K03495 http://www.genome.jp/dbget-bin/www_bget?KO:K03495 OMA FRPGYAI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FRPGYAI PDB 3CES http://www.ebi.ac.uk/pdbe-srv/view/entry/3CES PDB 3CP2 http://www.ebi.ac.uk/pdbe-srv/view/entry/3CP2 PDBsum 3CES http://www.ebi.ac.uk/pdbsum/3CES PDBsum 3CP2 http://www.ebi.ac.uk/pdbsum/3CP2 PROSITE PS01280 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01280 PROSITE PS01281 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01281 PSORT swissprot:MNMG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MNMG_ECOLI PSORT-B swissprot:MNMG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MNMG_ECOLI PSORT2 swissprot:MNMG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MNMG_ECOLI Pfam PF01134 http://pfam.xfam.org/family/PF01134 Pfam PF13932 http://pfam.xfam.org/family/PF13932 Phobius swissprot:MNMG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MNMG_ECOLI PhylomeDB P0A6U3 http://phylomedb.org/?seqid=P0A6U3 ProteinModelPortal P0A6U3 http://www.proteinmodelportal.org/query/uniprot/P0A6U3 PubMed 11544186 http://www.ncbi.nlm.nih.gov/pubmed/11544186 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17062623 http://www.ncbi.nlm.nih.gov/pubmed/17062623 PubMed 18565343 http://www.ncbi.nlm.nih.gov/pubmed/18565343 PubMed 370832 http://www.ncbi.nlm.nih.gov/pubmed/370832 PubMed 6357950 http://www.ncbi.nlm.nih.gov/pubmed/6357950 PubMed 6395859 http://www.ncbi.nlm.nih.gov/pubmed/6395859 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9603884 http://www.ncbi.nlm.nih.gov/pubmed/9603884 RefSeq NP_418197 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418197 RefSeq WP_000499788 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000499788 SMR P0A6U3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6U3 STRING 511145.b3741 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3741&targetmode=cogs STRING COG0445 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0445&targetmode=cogs SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 TIGRFAMs TIGR00136 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00136 UniProtKB MNMG_ECOLI http://www.uniprot.org/uniprot/MNMG_ECOLI UniProtKB-AC P0A6U3 http://www.uniprot.org/uniprot/P0A6U3 charge swissprot:MNMG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MNMG_ECOLI eggNOG COG0445 http://eggnogapi.embl.de/nog_data/html/tree/COG0445 eggNOG ENOG4107RE5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107RE5 epestfind swissprot:MNMG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MNMG_ECOLI garnier swissprot:MNMG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MNMG_ECOLI helixturnhelix swissprot:MNMG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MNMG_ECOLI hmoment swissprot:MNMG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MNMG_ECOLI iep swissprot:MNMG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MNMG_ECOLI inforesidue swissprot:MNMG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MNMG_ECOLI octanol swissprot:MNMG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MNMG_ECOLI pepcoil swissprot:MNMG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MNMG_ECOLI pepdigest swissprot:MNMG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MNMG_ECOLI pepinfo swissprot:MNMG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MNMG_ECOLI pepnet swissprot:MNMG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MNMG_ECOLI pepstats swissprot:MNMG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MNMG_ECOLI pepwheel swissprot:MNMG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MNMG_ECOLI pepwindow swissprot:MNMG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MNMG_ECOLI sigcleave swissprot:MNMG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MNMG_ECOLI ## Database ID URL or Descriptions # DrugBank DB00254 Doxycycline # DrugBank DB00256 Lymecycline # DrugBank DB00453 Clomocycline # DrugBank DB00560 Tigecycline # DrugBank DB00595 Oxytetracycline # DrugBank DB00618 Demeclocycline # DrugBank DB01017 Minocycline # DrugBank DB01301 Rolitetracycline # EcoGene EG10908 rpsI # FUNCTION RS9_ECOLI The C-terminal tail plays a role in the affinity of the 30S P site for different tRNAs. Mutations that decrease this affinity are suppressed in the 70S ribosome. {ECO 0000269|PubMed 15308780}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0022627 cytosolic small ribosomal subunit; IDA:EcoCyc. # GO_function GO:0000049 tRNA binding; IEA:UniProtKB-KW. # GO_function GO:0003735 structural constituent of ribosome; IBA:GO_Central. # GO_process GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central. # GO_process GO:0006412 translation; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_process GO:0006412 translation # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.30.230.10 -; 1. # HAMAP MF_00532_B Ribosomal_S9_B # IntAct P0A7X3 148 # InterPro IPR000754 Ribosomal_S9 # InterPro IPR014721 Ribosomal_S5_D2-typ_fold_subgr # InterPro IPR020568 Ribosomal_S5_D2-typ_fold # InterPro IPR020574 Ribosomal_S9_CS # InterPro IPR023035 Ribosomal_S9_bac/plastid # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 M00179 Ribosome, archaea # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=14723.3; Method=MALDI; Range=2-130; Evidence={ECO:0000269|PubMed 10094780}; # Organism RS9_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21569 PTHR21569 # PATRIC 32121886 VBIEscCol129921_3327 # PDB 1M5G Model; -; I=4-130 # PDB 2YKR EM; 9.80 A; I=4-130 # PDB 3J9Y EM; 3.90 A; i=1-130 # PDB 3J9Z EM; 3.60 A; SI=2-130 # PDB 3JA1 EM; 3.60 A; SI=2-130 # PDB 3JBU EM; 3.64 A; I=1-130 # PDB 3JBV EM; 3.32 A; I=1-130 # PDB 3JCD EM; 3.70 A; i=1-130 # PDB 3JCE EM; 3.20 A; i=1-130 # PDB 3JCJ EM; 3.70 A; o=1-130 # PDB 3JCN EM; 4.60 A; j=1-130 # PDB 4A2I EM; 16.50 A; I=4-130 # PDB 4ADV EM; 13.50 A; I=2-130 # PDB 4U1U X-ray; 2.95 A; AI/CI=4-130 # PDB 4U1V X-ray; 3.00 A; AI/CI=4-130 # PDB 4U20 X-ray; 2.90 A; AI/CI=4-130 # PDB 4U24 X-ray; 2.90 A; AI/CI=4-130 # PDB 4U25 X-ray; 2.90 A; AI/CI=4-130 # PDB 4U26 X-ray; 2.80 A; AI/CI=4-130 # PDB 4U27 X-ray; 2.80 A; AI/CI=4-130 # PDB 4V47 EM; 12.30 A; BI=2-130 # PDB 4V48 EM; 11.50 A; BI=2-130 # PDB 4V4H X-ray; 3.46 A; AI/CI=1-130 # PDB 4V4Q X-ray; 3.46 A; AI/CI=2-130 # PDB 4V4V EM; 15.00 A; AI=5-130 # PDB 4V4W EM; 15.00 A; AI=5-130 # PDB 4V50 X-ray; 3.22 A; AI/CI=2-130 # PDB 4V52 X-ray; 3.21 A; AI/CI=2-130 # PDB 4V53 X-ray; 3.54 A; AI/CI=2-130 # PDB 4V54 X-ray; 3.30 A; AI/CI=2-130 # PDB 4V55 X-ray; 4.00 A; AI/CI=2-130 # PDB 4V56 X-ray; 3.93 A; AI/CI=2-130 # PDB 4V57 X-ray; 3.50 A; AI/CI=2-130 # PDB 4V5B X-ray; 3.74 A; BI/DI=2-130 # PDB 4V5H EM; 5.80 A; AI=4-130 # PDB 4V5Y X-ray; 4.45 A; AI/CI=2-130 # PDB 4V64 X-ray; 3.50 A; AI/CI=2-130 # PDB 4V65 EM; 9.00 A; AW=1-130 # PDB 4V66 EM; 9.00 A; AW=1-130 # PDB 4V69 EM; 6.70 A; AI=4-130 # PDB 4V6C X-ray; 3.19 A; AI/CI=1-130 # PDB 4V6D X-ray; 3.81 A; AI/CI=1-130 # PDB 4V6E X-ray; 3.71 A; AI/CI=1-130 # PDB 4V6K EM; 8.25 A; BM=1-130 # PDB 4V6L EM; 13.20 A; AM=1-130 # PDB 4V6M EM; 7.10 A; AI=2-130 # PDB 4V6N EM; 12.10 A; BL=2-130 # PDB 4V6O EM; 14.70 A; AL=2-130 # PDB 4V6P EM; 13.50 A; AL=2-130 # PDB 4V6Q EM; 11.50 A; AL=2-130 # PDB 4V6R EM; 11.50 A; AL=2-130 # PDB 4V6S EM; 13.10 A; BK=2-130 # PDB 4V6T EM; 8.30 A; AI=4-130 # PDB 4V6V EM; 9.80 A; AI=2-130 # PDB 4V6Y EM; 12.00 A; AI=4-130 # PDB 4V6Z EM; 12.00 A; AI=4-130 # PDB 4V70 EM; 17.00 A; AI=4-130 # PDB 4V71 EM; 20.00 A; AI=4-130 # PDB 4V72 EM; 13.00 A; AI=4-130 # PDB 4V73 EM; 15.00 A; AI=4-130 # PDB 4V74 EM; 17.00 A; AI=4-130 # PDB 4V75 EM; 12.00 A; AI=4-130 # PDB 4V76 EM; 17.00 A; AI=4-130 # PDB 4V77 EM; 17.00 A; AI=4-130 # PDB 4V78 EM; 20.00 A; AI=4-130 # PDB 4V79 EM; 15.00 A; AI=4-130 # PDB 4V7A EM; 9.00 A; AI=4-130 # PDB 4V7B EM; 6.80 A; AI=1-130 # PDB 4V7C EM; 7.60 A; AI=2-130 # PDB 4V7D EM; 7.60 A; BI=2-130 # PDB 4V7I EM; 9.60 A; BI=1-130 # PDB 4V7S X-ray; 3.25 A; AI/CI=4-130 # PDB 4V7T X-ray; 3.19 A; AI/CI=4-130 # PDB 4V7U X-ray; 3.10 A; AI/CI=4-130 # PDB 4V7V X-ray; 3.29 A; AI/CI=4-130 # PDB 4V85 X-ray; 3.20 A; I=1-130 # PDB 4V89 X-ray; 3.70 A; AI=1-130 # PDB 4V9C X-ray; 3.30 A; AI/CI=1-130 # PDB 4V9D X-ray; 3.00 A; AI/BI=4-130 # PDB 4V9O X-ray; 2.90 A; BI/DI/FI/HI=1-130 # PDB 4V9P X-ray; 2.90 A; BI/DI/FI/HI=1-130 # PDB 4WF1 X-ray; 3.09 A; AI/CI=4-130 # PDB 4WOI X-ray; 3.00 A; AI/DI=1-130 # PDB 4WWW X-ray; 3.10 A; QI/XI=4-130 # PDB 4YBB X-ray; 2.10 A; AI/BI=4-130 # PDB 5AFI EM; 2.90 A; i=1-130 # PDB 5IQR EM; 3.00 A; n=1-130 # PDB 5IT8 X-ray; 3.12 A; AI/BI=4-130 # PDB 5J5B X-ray; 2.80 A; AI/BI=4-130 # PDB 5J7L X-ray; 3.00 A; AI/BI=4-130 # PDB 5J88 X-ray; 3.32 A; AI/BI=4-130 # PDB 5J8A X-ray; 3.10 A; AI/BI=4-130 # PDB 5J91 X-ray; 2.96 A; AI/BI=4-130 # PDB 5JC9 X-ray; 3.03 A; AI/BI=4-130 # PDB 5JTE EM; 3.60 A; AI=1-130 # PDB 5JU8 EM; 3.60 A; AI=1-130 # PDB 5KCR EM; 3.60 A; 1i=1-130 # PDB 5KCS EM; 3.90 A; 1i=1-130 # PDB 5KPS EM; 3.90 A; 14=1-130 # PDB 5KPV EM; 4.10 A; 13=1-130 # PDB 5KPW EM; 3.90 A; 13=1-130 # PDB 5KPX EM; 3.90 A; 13=1-130 # PDB 5L3P EM; 3.70 A; i=1-130 # PIR H65114 R3EC9 # PROSITE PS00360 RIBOSOMAL_S9 # Pfam PF00380 Ribosomal_S9 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RS9_ECOLI 30S ribosomal protein S9 # RefSeq NP_417697 NC_000913.3 # RefSeq WP_000829818 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein S9P family. {ECO 0000305}. # SUBUNIT RS9_ECOLI Part of the 30S ribosomal subunit. Cross-links to the P site tRNA and weakly to the A site tRNA. # SUPFAM SSF54211 SSF54211 # eggNOG COG0103 LUCA BLAST swissprot:RS9_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RS9_ECOLI BioCyc ECOL316407:JW3199-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3199-MONOMER BioCyc EcoCyc:EG10908-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10908-MONOMER BioCyc MetaCyc:EG10908-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10908-MONOMER COG COG0103 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0103 DIP DIP-35799N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35799N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1007/BF00383007 http://dx.doi.org/10.1007/BF00383007 DOI 10.1016/0014-5793(75)80656-9 http://dx.doi.org/10.1016/0014-5793(75)80656-9 DOI 10.1016/S0092-8674(03)00427-6 http://dx.doi.org/10.1016/S0092-8674(03)00427-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb841 http://dx.doi.org/10.1038/nsb841 DOI 10.1073/pnas.0405227101 http://dx.doi.org/10.1073/pnas.0405227101 DOI 10.1073/pnas.70.1.151 http://dx.doi.org/10.1073/pnas.70.1.151 DOI 10.1093/nar/23.22.4635 http://dx.doi.org/10.1093/nar/23.22.4635 DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB00254 http://www.drugbank.ca/drugs/DB00254 DrugBank DB00256 http://www.drugbank.ca/drugs/DB00256 DrugBank DB00453 http://www.drugbank.ca/drugs/DB00453 DrugBank DB00560 http://www.drugbank.ca/drugs/DB00560 DrugBank DB00595 http://www.drugbank.ca/drugs/DB00595 DrugBank DB00618 http://www.drugbank.ca/drugs/DB00618 DrugBank DB01017 http://www.drugbank.ca/drugs/DB01017 DrugBank DB01301 http://www.drugbank.ca/drugs/DB01301 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X02130 http://www.ebi.ac.uk/ena/data/view/X02130 EchoBASE EB0901 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0901 EcoGene EG10908 http://www.ecogene.org/geneInfo.php?eg_id=EG10908 EnsemblBacteria AAC76262 http://www.ensemblgenomes.org/id/AAC76262 EnsemblBacteria AAC76262 http://www.ensemblgenomes.org/id/AAC76262 EnsemblBacteria BAE77273 http://www.ensemblgenomes.org/id/BAE77273 EnsemblBacteria BAE77273 http://www.ensemblgenomes.org/id/BAE77273 EnsemblBacteria BAE77273 http://www.ensemblgenomes.org/id/BAE77273 EnsemblBacteria b3230 http://www.ensemblgenomes.org/id/b3230 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0022627 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022627 GO_function GO:0000049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000049 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_process GO:0000462 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000462 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.30.230.10 http://www.cathdb.info/version/latest/superfamily/3.30.230.10 GeneID 5550578 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5550578 GeneID 949000 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949000 HAMAP MF_00532_B http://hamap.expasy.org/unirule/MF_00532_B HOGENOM HOG000019802 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000019802&db=HOGENOM6 InParanoid P0A7X3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7X3 IntAct P0A7X3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7X3* InterPro IPR000754 http://www.ebi.ac.uk/interpro/entry/IPR000754 InterPro IPR014721 http://www.ebi.ac.uk/interpro/entry/IPR014721 InterPro IPR020568 http://www.ebi.ac.uk/interpro/entry/IPR020568 InterPro IPR020574 http://www.ebi.ac.uk/interpro/entry/IPR020574 InterPro IPR023035 http://www.ebi.ac.uk/interpro/entry/IPR023035 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW3199 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3199 KEGG_Gene eco:b3230 http://www.genome.jp/dbget-bin/www_bget?eco:b3230 KEGG_Orthology KO:K02996 http://www.genome.jp/dbget-bin/www_bget?KO:K02996 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 MINT MINT-1290939 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1290939 OMA IKQGAAR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IKQGAAR PANTHER PTHR21569 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21569 PDB 1M5G http://www.ebi.ac.uk/pdbe-srv/view/entry/1M5G PDB 2YKR http://www.ebi.ac.uk/pdbe-srv/view/entry/2YKR PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 4A2I http://www.ebi.ac.uk/pdbe-srv/view/entry/4A2I PDB 4ADV http://www.ebi.ac.uk/pdbe-srv/view/entry/4ADV PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4V47 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V47 PDB 4V48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V48 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 1M5G http://www.ebi.ac.uk/pdbsum/1M5G PDBsum 2YKR http://www.ebi.ac.uk/pdbsum/2YKR PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 4A2I http://www.ebi.ac.uk/pdbsum/4A2I PDBsum 4ADV http://www.ebi.ac.uk/pdbsum/4ADV PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4V47 http://www.ebi.ac.uk/pdbsum/4V47 PDBsum 4V48 http://www.ebi.ac.uk/pdbsum/4V48 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PROSITE PS00360 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00360 PSORT swissprot:RS9_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RS9_ECOLI PSORT-B swissprot:RS9_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RS9_ECOLI PSORT2 swissprot:RS9_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RS9_ECOLI Pfam PF00380 http://pfam.xfam.org/family/PF00380 Phobius swissprot:RS9_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RS9_ECOLI PhylomeDB P0A7X3 http://phylomedb.org/?seqid=P0A7X3 ProteinModelPortal P0A7X3 http://www.proteinmodelportal.org/query/uniprot/P0A7X3 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 1091515 http://www.ncbi.nlm.nih.gov/pubmed/1091515 PubMed 12244297 http://www.ncbi.nlm.nih.gov/pubmed/12244297 PubMed 12809609 http://www.ncbi.nlm.nih.gov/pubmed/12809609 PubMed 15308780 http://www.ncbi.nlm.nih.gov/pubmed/15308780 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3884974 http://www.ncbi.nlm.nih.gov/pubmed/3884974 PubMed 4346030 http://www.ncbi.nlm.nih.gov/pubmed/4346030 PubMed 7556101 http://www.ncbi.nlm.nih.gov/pubmed/7556101 PubMed 8524654 http://www.ncbi.nlm.nih.gov/pubmed/8524654 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417697 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417697 RefSeq WP_000829818 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000829818 SMR P0A7X3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7X3 STRING 511145.b3230 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3230&targetmode=cogs STRING COG0103 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0103&targetmode=cogs SUPFAM SSF54211 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54211 UniProtKB RS9_ECOLI http://www.uniprot.org/uniprot/RS9_ECOLI UniProtKB-AC P0A7X3 http://www.uniprot.org/uniprot/P0A7X3 charge swissprot:RS9_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RS9_ECOLI eggNOG COG0103 http://eggnogapi.embl.de/nog_data/html/tree/COG0103 epestfind swissprot:RS9_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RS9_ECOLI garnier swissprot:RS9_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RS9_ECOLI helixturnhelix swissprot:RS9_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RS9_ECOLI hmoment swissprot:RS9_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RS9_ECOLI iep swissprot:RS9_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RS9_ECOLI inforesidue swissprot:RS9_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RS9_ECOLI octanol swissprot:RS9_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RS9_ECOLI pepcoil swissprot:RS9_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RS9_ECOLI pepdigest swissprot:RS9_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RS9_ECOLI pepinfo swissprot:RS9_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RS9_ECOLI pepnet swissprot:RS9_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RS9_ECOLI pepstats swissprot:RS9_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RS9_ECOLI pepwheel swissprot:RS9_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RS9_ECOLI pepwindow swissprot:RS9_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RS9_ECOLI sigcleave swissprot:RS9_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RS9_ECOLI ## Database ID URL or Descriptions # BioGrid 4262566 4 # EcoGene EG11683 yicG # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR005115 UPF0126 # Organism YICG_ECOLI Escherichia coli (strain K12) # PATRIC 32122779 VBIEscCol129921_3766 # PIR H65165 H65165 # Pfam PF03458 UPF0126; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YICG_ECOLI UPF0126 inner membrane protein YicG # RefSeq NP_418103 NC_000913.3 # RefSeq WP_000924289 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA61999.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the UPF0126 family. {ECO 0000305}. # SUBCELLULAR LOCATION YICG_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 1.A.62.2 the homotrimeric cation channel (tric) family # eggNOG COG2860 LUCA # eggNOG ENOG4105EN6 Bacteria BLAST swissprot:YICG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YICG_ECOLI BioCyc ECOL316407:JW3621-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3621-MONOMER BioCyc EcoCyc:EG11683-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11683-MONOMER DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1634 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1634 EcoGene EG11683 http://www.ecogene.org/geneInfo.php?eg_id=EG11683 EnsemblBacteria AAC76670 http://www.ensemblgenomes.org/id/AAC76670 EnsemblBacteria AAC76670 http://www.ensemblgenomes.org/id/AAC76670 EnsemblBacteria BAE77647 http://www.ensemblgenomes.org/id/BAE77647 EnsemblBacteria BAE77647 http://www.ensemblgenomes.org/id/BAE77647 EnsemblBacteria BAE77647 http://www.ensemblgenomes.org/id/BAE77647 EnsemblBacteria b3646 http://www.ensemblgenomes.org/id/b3646 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 948165 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948165 HOGENOM HOG000218257 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218257&db=HOGENOM6 InParanoid P0AGM2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGM2 InterPro IPR005115 http://www.ebi.ac.uk/interpro/entry/IPR005115 KEGG_Gene ecj:JW3621 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3621 KEGG_Gene eco:b3646 http://www.genome.jp/dbget-bin/www_bget?eco:b3646 OMA LIAIRYR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LIAIRYR PSORT swissprot:YICG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YICG_ECOLI PSORT-B swissprot:YICG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YICG_ECOLI PSORT2 swissprot:YICG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YICG_ECOLI Pfam PF03458 http://pfam.xfam.org/family/PF03458 Phobius swissprot:YICG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YICG_ECOLI PhylomeDB P0AGM2 http://phylomedb.org/?seqid=P0AGM2 ProteinModelPortal P0AGM2 http://www.proteinmodelportal.org/query/uniprot/P0AGM2 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418103 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418103 RefSeq WP_000924289 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000924289 STRING 511145.b3646 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3646&targetmode=cogs TCDB 1.A.62.2 http://www.tcdb.org/search/result.php?tc=1.A.62.2 UniProtKB YICG_ECOLI http://www.uniprot.org/uniprot/YICG_ECOLI UniProtKB-AC P0AGM2 http://www.uniprot.org/uniprot/P0AGM2 charge swissprot:YICG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YICG_ECOLI eggNOG COG2860 http://eggnogapi.embl.de/nog_data/html/tree/COG2860 eggNOG ENOG4105EN6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EN6 epestfind swissprot:YICG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YICG_ECOLI garnier swissprot:YICG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YICG_ECOLI helixturnhelix swissprot:YICG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YICG_ECOLI hmoment swissprot:YICG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YICG_ECOLI iep swissprot:YICG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YICG_ECOLI inforesidue swissprot:YICG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YICG_ECOLI octanol swissprot:YICG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YICG_ECOLI pepcoil swissprot:YICG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YICG_ECOLI pepdigest swissprot:YICG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YICG_ECOLI pepinfo swissprot:YICG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YICG_ECOLI pepnet swissprot:YICG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YICG_ECOLI pepstats swissprot:YICG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YICG_ECOLI pepwheel swissprot:YICG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YICG_ECOLI pepwindow swissprot:YICG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YICG_ECOLI sigcleave swissprot:YICG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YICG_ECOLI ## Database ID URL or Descriptions # EcoGene EG10291 fecI # FUNCTION FECI_ECOLI Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor regulates the fec genes for iron dicitrate transport (Probable). {ECO 0000305}. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_function GO:0016987 sigma factor activity; IEA:UniProtKB-KW. # GO_process GO:0006352 DNA-templated transcription, initiation; IEA:InterPro. # GO_process GO:0006811 ion transport; IEA:UniProtKB-KW. # GO_process GO:0055072 iron ion homeostasis; IEA:UniProtKB-KW. # GOslim_function GO:0000988 transcription factor activity, protein binding # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006810 transport # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0042592 homeostatic process # Gene3D 1.10.10.10 -; 1. # INDUCTION Induced 2.1-fold by hydroxyurea. {ECO:0000269|PubMed 20005847}. # IntAct P23484 8 # InterPro IPR000838 RNA_pol_sigma70_ECF_CS # InterPro IPR007627 RNA_pol_sigma70_r2 # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR013249 RNA_pol_sigma70_r4_t2 # InterPro IPR013324 RNA_pol_sigma_r3_r4 # InterPro IPR013325 RNA_pol_sigma_r2 # InterPro IPR014284 RNA_pol_sigma-70_dom # KEGG_Brite ko03021 Transcription machinery # Organism FECI_ECOLI Escherichia coli (strain K12) # PATRIC 32124165 VBIEscCol129921_4426 # PIR JV0111 JV0111 # PROSITE PS01063 SIGMA70_ECF # Pfam PF04542 Sigma70_r2 # Pfam PF08281 Sigma70_r4_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FECI_ECOLI Probable RNA polymerase sigma factor FecI # RefSeq NP_418713 NC_000913.3 # RefSeq WP_001283626 NZ_LN832404.1 # SIMILARITY Belongs to the sigma-70 factor family. ECF subfamily. {ECO 0000305}. # SUPFAM SSF88659 SSF88659 # SUPFAM SSF88946 SSF88946 # TIGRFAMs TIGR02937 sigma70-ECF # eggNOG COG1595 LUCA # eggNOG ENOG4108SF5 Bacteria BLAST swissprot:FECI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FECI_ECOLI BioCyc ECOL316407:JW4253-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4253-MONOMER BioCyc EcoCyc:PD00440 http://biocyc.org/getid?id=EcoCyc:PD00440 BioCyc MetaCyc:PD00440 http://biocyc.org/getid?id=MetaCyc:PD00440 COG COG1595 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1595 DIP DIP-9588N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9588N DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.91.16.7573 http://dx.doi.org/10.1073/pnas.91.16.7573 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1111/j.1365-2958.1995.mmi_18010163.x http://dx.doi.org/10.1111/j.1365-2958.1995.mmi_18010163.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M63115 http://www.ebi.ac.uk/ena/data/view/M63115 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB0287 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0287 EcoGene EG10291 http://www.ecogene.org/geneInfo.php?eg_id=EG10291 EnsemblBacteria AAC77249 http://www.ensemblgenomes.org/id/AAC77249 EnsemblBacteria AAC77249 http://www.ensemblgenomes.org/id/AAC77249 EnsemblBacteria BAE78284 http://www.ensemblgenomes.org/id/BAE78284 EnsemblBacteria BAE78284 http://www.ensemblgenomes.org/id/BAE78284 EnsemblBacteria BAE78284 http://www.ensemblgenomes.org/id/BAE78284 EnsemblBacteria b4293 http://www.ensemblgenomes.org/id/b4293 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0016987 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016987 GO_process GO:0006352 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006352 GO_process GO:0006811 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811 GO_process GO:0055072 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055072 GOslim_function GO:0000988 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000988 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 946839 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946839 HOGENOM HOG000094759 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000094759&db=HOGENOM6 InParanoid P23484 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23484 IntAct P23484 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P23484* InterPro IPR000838 http://www.ebi.ac.uk/interpro/entry/IPR000838 InterPro IPR007627 http://www.ebi.ac.uk/interpro/entry/IPR007627 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR013249 http://www.ebi.ac.uk/interpro/entry/IPR013249 InterPro IPR013324 http://www.ebi.ac.uk/interpro/entry/IPR013324 InterPro IPR013325 http://www.ebi.ac.uk/interpro/entry/IPR013325 InterPro IPR014284 http://www.ebi.ac.uk/interpro/entry/IPR014284 KEGG_Brite ko03021 http://www.genome.jp/dbget-bin/www_bget?ko03021 KEGG_Gene ecj:JW4253 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4253 KEGG_Gene eco:b4293 http://www.genome.jp/dbget-bin/www_bget?eco:b4293 KEGG_Orthology KO:K03088 http://www.genome.jp/dbget-bin/www_bget?KO:K03088 MINT MINT-119346 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-119346 OMA DIREPRP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DIREPRP PROSITE PS01063 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01063 PSORT swissprot:FECI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FECI_ECOLI PSORT-B swissprot:FECI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FECI_ECOLI PSORT2 swissprot:FECI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FECI_ECOLI Pfam PF04542 http://pfam.xfam.org/family/PF04542 Pfam PF08281 http://pfam.xfam.org/family/PF08281 Phobius swissprot:FECI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FECI_ECOLI PhylomeDB P23484 http://phylomedb.org/?seqid=P23484 ProteinModelPortal P23484 http://www.proteinmodelportal.org/query/uniprot/P23484 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 2254251 http://www.ncbi.nlm.nih.gov/pubmed/2254251 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8052622 http://www.ncbi.nlm.nih.gov/pubmed/8052622 PubMed 8596456 http://www.ncbi.nlm.nih.gov/pubmed/8596456 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418713 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418713 RefSeq WP_001283626 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001283626 SMR P23484 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P23484 STRING 511145.b4293 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4293&targetmode=cogs STRING COG1595 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1595&targetmode=cogs SUPFAM SSF88659 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF88659 SUPFAM SSF88946 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF88946 TIGRFAMs TIGR02937 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02937 UniProtKB FECI_ECOLI http://www.uniprot.org/uniprot/FECI_ECOLI UniProtKB-AC P23484 http://www.uniprot.org/uniprot/P23484 charge swissprot:FECI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FECI_ECOLI eggNOG COG1595 http://eggnogapi.embl.de/nog_data/html/tree/COG1595 eggNOG ENOG4108SF5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108SF5 epestfind swissprot:FECI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FECI_ECOLI garnier swissprot:FECI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FECI_ECOLI helixturnhelix swissprot:FECI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FECI_ECOLI hmoment swissprot:FECI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FECI_ECOLI iep swissprot:FECI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FECI_ECOLI inforesidue swissprot:FECI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FECI_ECOLI octanol swissprot:FECI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FECI_ECOLI pepcoil swissprot:FECI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FECI_ECOLI pepdigest swissprot:FECI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FECI_ECOLI pepinfo swissprot:FECI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FECI_ECOLI pepnet swissprot:FECI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FECI_ECOLI pepstats swissprot:FECI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FECI_ECOLI pepwheel swissprot:FECI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FECI_ECOLI pepwindow swissprot:FECI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FECI_ECOLI sigcleave swissprot:FECI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FECI_ECOLI ## Database ID URL or Descriptions # BioGrid 4261726 8 # EcoGene EG11186 yiaA # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006950 response to stress # InterPro IPR008024 YiaAB # Organism YIAA_ECOLI Escherichia coli (strain K12) # PATRIC 32122600 VBIEscCol129921_3677 # Pfam PF05360 YiaAB; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIAA_ECOLI Inner membrane protein YiaA # RefSeq NP_418019 NC_000913.3 # RefSeq WP_001296808 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18539.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SUBCELLULAR LOCATION YIAA_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 9.B.44.1 the yiaa-yiab (yiaab) family # eggNOG COG4682 LUCA # eggNOG ENOG4108Z12 Bacteria BLAST swissprot:YIAA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIAA_ECOLI BioCyc ECOL316407:JW3534-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3534-MONOMER BioCyc EcoCyc:EG11186-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11186-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K01996 http://www.ebi.ac.uk/ena/data/view/K01996 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X04691 http://www.ebi.ac.uk/ena/data/view/X04691 EchoBASE EB1172 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1172 EcoGene EG11186 http://www.ecogene.org/geneInfo.php?eg_id=EG11186 EnsemblBacteria AAC76586 http://www.ensemblgenomes.org/id/AAC76586 EnsemblBacteria AAC76586 http://www.ensemblgenomes.org/id/AAC76586 EnsemblBacteria BAE77731 http://www.ensemblgenomes.org/id/BAE77731 EnsemblBacteria BAE77731 http://www.ensemblgenomes.org/id/BAE77731 EnsemblBacteria BAE77731 http://www.ensemblgenomes.org/id/BAE77731 EnsemblBacteria b3562 http://www.ensemblgenomes.org/id/b3562 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 948078 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948078 HOGENOM HOG000256697 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000256697&db=HOGENOM6 InterPro IPR008024 http://www.ebi.ac.uk/interpro/entry/IPR008024 KEGG_Gene ecj:JW3534 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3534 KEGG_Gene eco:b3562 http://www.genome.jp/dbget-bin/www_bget?eco:b3562 OMA QKNVRDS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QKNVRDS PSORT swissprot:YIAA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIAA_ECOLI PSORT-B swissprot:YIAA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIAA_ECOLI PSORT2 swissprot:YIAA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIAA_ECOLI Pfam PF05360 http://pfam.xfam.org/family/PF05360 Phobius swissprot:YIAA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIAA_ECOLI ProteinModelPortal P0ADJ8 http://www.proteinmodelportal.org/query/uniprot/P0ADJ8 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6320721 http://www.ncbi.nlm.nih.gov/pubmed/6320721 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418019 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418019 RefSeq WP_001296808 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001296808 STRING 511145.b3562 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3562&targetmode=cogs TCDB 9.B.44.1 http://www.tcdb.org/search/result.php?tc=9.B.44.1 UniProtKB YIAA_ECOLI http://www.uniprot.org/uniprot/YIAA_ECOLI UniProtKB-AC P0ADJ8 http://www.uniprot.org/uniprot/P0ADJ8 charge swissprot:YIAA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIAA_ECOLI eggNOG COG4682 http://eggnogapi.embl.de/nog_data/html/tree/COG4682 eggNOG ENOG4108Z12 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Z12 epestfind swissprot:YIAA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIAA_ECOLI garnier swissprot:YIAA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIAA_ECOLI helixturnhelix swissprot:YIAA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIAA_ECOLI hmoment swissprot:YIAA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIAA_ECOLI iep swissprot:YIAA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIAA_ECOLI inforesidue swissprot:YIAA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIAA_ECOLI octanol swissprot:YIAA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIAA_ECOLI pepcoil swissprot:YIAA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIAA_ECOLI pepdigest swissprot:YIAA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIAA_ECOLI pepinfo swissprot:YIAA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIAA_ECOLI pepnet swissprot:YIAA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIAA_ECOLI pepstats swissprot:YIAA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIAA_ECOLI pepwheel swissprot:YIAA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIAA_ECOLI pepwindow swissprot:YIAA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIAA_ECOLI sigcleave swissprot:YIAA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIAA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260993 6 # CATALYTIC ACTIVITY DGTP_ECOLI dGTP + H(2)O = deoxyguanosine + triphosphate. {ECO 0000255|HAMAP-Rule MF_00030, ECO 0000269|PubMed 2826481}. # COFACTOR DGTP_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_00030, ECO 0000269|PubMed 2826481}; # EcoGene EG10225 dgt # FUNCTION DGTP_ECOLI dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs. {ECO 0000255|HAMAP-Rule MF_00030, ECO 0000269|PubMed 2826481}. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0003697 single-stranded DNA binding; IDA:EcoCyc. # GO_function GO:0003924 GTPase activity; IDA:EcoliWiki. # GO_function GO:0008832 dGTPase activity; IDA:EcoCyc. # GO_function GO:0030145 manganese ion binding; IDA:EcoliWiki. # GO_function GO:0050897 cobalt ion binding; IDA:EcoliWiki. # GO_process GO:0006203 dGTP catabolic process; IBA:GO_Central. # GO_process GO:0015949 nucleobase-containing small molecule interconversion; IDA:EcoCyc. # GO_process GO:0046039 GTP metabolic process; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0003924 GTPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.3210.10 -; 2. # Gene3D 1.10.3410.10 -; 1. # Gene3D 1.10.3550.10 -; 2. # HAMAP MF_00030 dGTPase_type1 # IntAct P15723 5 # InterPro IPR003607 HD/PDEase_dom # InterPro IPR006261 dGTP_triP_hydro # InterPro IPR006674 HD_domain # InterPro IPR020779 dGTP_triP_hydro_proteobacteria # InterPro IPR023293 dGTP_triP_hydro_central # InterPro IPR027432 dGTP_triphosphohydrolase_C_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # Organism DGTP_ECOLI Escherichia coli (strain K12) # PATRIC 32115429 VBIEscCol129921_0166 # PDB 4X9E X-ray; 3.10 A; A/B/C/D/E/F=1-505 # PDB 4XDS X-ray; 3.35 A; A/B/C/D/E/F=1-505 # PIR A35993 A35993 # Pfam PF01966 HD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Deoxyguanosinetriphosphate triphosphohydrolase {ECO:0000255|HAMAP-Rule MF_00030} # RefSeq NP_414702 NC_000913.3 # RefSeq WP_000057073 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA23716.1; Type=Frameshift; Positions=90, 211; Evidence={ECO 0000305}; # SIMILARITY Belongs to the dGTPase family. Type 1 subfamily. {ECO:0000255|HAMAP-Rule MF_00030}. # SMART SM00471 HDc # SUBUNIT DGTP_ECOLI Homotetramer. {ECO 0000255|HAMAP-Rule MF_00030, ECO 0000269|PubMed 2826481}. # TIGRFAMs TIGR01353 dGTP_triPase # eggNOG COG0232 LUCA # eggNOG ENOG4105C4Q Bacteria BLAST swissprot:DGTP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DGTP_ECOLI BioCyc ECOL316407:JW0156-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0156-MONOMER BioCyc EcoCyc:DGTPTRIPHYDRO-MONOMER http://biocyc.org/getid?id=EcoCyc:DGTPTRIPHYDRO-MONOMER BioCyc MetaCyc:DGTPTRIPHYDRO-MONOMER http://biocyc.org/getid?id=MetaCyc:DGTPTRIPHYDRO-MONOMER COG COG0232 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0232 DIP DIP-9437N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9437N DOI 10.1016/0378-1119(90)90200-B http://dx.doi.org/10.1016/0378-1119(90)90200-B DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.87.7.2740 http://dx.doi.org/10.1073/pnas.87.7.2740 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.5.1 {ECO:0000255|HAMAP-Rule:MF_00030} http://www.genome.jp/dbget-bin/www_bget?EC:3.1.5.1 {ECO:0000255|HAMAP-Rule:MF_00030} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M29955 http://www.ebi.ac.uk/ena/data/view/M29955 EMBL M31772 http://www.ebi.ac.uk/ena/data/view/M31772 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 ENZYME 3.1.5.1 {ECO:0000255|HAMAP-Rule:MF_00030} http://enzyme.expasy.org/EC/3.1.5.1 {ECO:0000255|HAMAP-Rule:MF_00030} EchoBASE EB0221 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0221 EcoGene EG10225 http://www.ecogene.org/geneInfo.php?eg_id=EG10225 EnsemblBacteria AAC73271 http://www.ensemblgenomes.org/id/AAC73271 EnsemblBacteria AAC73271 http://www.ensemblgenomes.org/id/AAC73271 EnsemblBacteria BAB96737 http://www.ensemblgenomes.org/id/BAB96737 EnsemblBacteria BAB96737 http://www.ensemblgenomes.org/id/BAB96737 EnsemblBacteria BAB96737 http://www.ensemblgenomes.org/id/BAB96737 EnsemblBacteria b0160 http://www.ensemblgenomes.org/id/b0160 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0003697 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003697 GO_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GO_function GO:0008832 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008832 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_function GO:0050897 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050897 GO_process GO:0006203 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006203 GO_process GO:0015949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015949 GO_process GO:0046039 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046039 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0003924 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003924 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.3210.10 http://www.cathdb.info/version/latest/superfamily/1.10.3210.10 Gene3D 1.10.3410.10 http://www.cathdb.info/version/latest/superfamily/1.10.3410.10 Gene3D 1.10.3550.10 http://www.cathdb.info/version/latest/superfamily/1.10.3550.10 GeneID 947177 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947177 HAMAP MF_00030 http://hamap.expasy.org/unirule/MF_00030 HOGENOM HOG000082150 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000082150&db=HOGENOM6 InParanoid P15723 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P15723 IntAct P15723 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P15723* IntEnz 3.1.5.1 {ECO:0000255|HAMAP-Rule:MF_00030} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.5.1 {ECO:0000255|HAMAP-Rule:MF_00030} InterPro IPR003607 http://www.ebi.ac.uk/interpro/entry/IPR003607 InterPro IPR006261 http://www.ebi.ac.uk/interpro/entry/IPR006261 InterPro IPR006674 http://www.ebi.ac.uk/interpro/entry/IPR006674 InterPro IPR020779 http://www.ebi.ac.uk/interpro/entry/IPR020779 InterPro IPR023293 http://www.ebi.ac.uk/interpro/entry/IPR023293 InterPro IPR027432 http://www.ebi.ac.uk/interpro/entry/IPR027432 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0156 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0156 KEGG_Gene eco:b0160 http://www.genome.jp/dbget-bin/www_bget?eco:b0160 KEGG_Orthology KO:K01129 http://www.genome.jp/dbget-bin/www_bget?KO:K01129 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Reaction rn:R01856 http://www.genome.jp/dbget-bin/www_bget?rn:R01856 MINT MINT-1223226 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1223226 OMA KTDFVHT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KTDFVHT PDB 4X9E http://www.ebi.ac.uk/pdbe-srv/view/entry/4X9E PDB 4XDS http://www.ebi.ac.uk/pdbe-srv/view/entry/4XDS PDBsum 4X9E http://www.ebi.ac.uk/pdbsum/4X9E PDBsum 4XDS http://www.ebi.ac.uk/pdbsum/4XDS PSORT swissprot:DGTP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DGTP_ECOLI PSORT-B swissprot:DGTP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DGTP_ECOLI PSORT2 swissprot:DGTP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DGTP_ECOLI Pfam PF01966 http://pfam.xfam.org/family/PF01966 Phobius swissprot:DGTP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DGTP_ECOLI PhylomeDB P15723 http://phylomedb.org/?seqid=P15723 ProteinModelPortal P15723 http://www.proteinmodelportal.org/query/uniprot/P15723 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2157212 http://www.ncbi.nlm.nih.gov/pubmed/2157212 PubMed 2165018 http://www.ncbi.nlm.nih.gov/pubmed/2165018 PubMed 2826481 http://www.ncbi.nlm.nih.gov/pubmed/2826481 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414702 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414702 RefSeq WP_000057073 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000057073 SMART SM00471 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00471 SMR P15723 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P15723 STRING 511145.b0160 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0160&targetmode=cogs STRING COG0232 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0232&targetmode=cogs TIGRFAMs TIGR01353 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01353 UniProtKB DGTP_ECOLI http://www.uniprot.org/uniprot/DGTP_ECOLI UniProtKB-AC P15723 http://www.uniprot.org/uniprot/P15723 charge swissprot:DGTP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DGTP_ECOLI eggNOG COG0232 http://eggnogapi.embl.de/nog_data/html/tree/COG0232 eggNOG ENOG4105C4Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C4Q epestfind swissprot:DGTP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DGTP_ECOLI garnier swissprot:DGTP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DGTP_ECOLI helixturnhelix swissprot:DGTP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DGTP_ECOLI hmoment swissprot:DGTP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DGTP_ECOLI iep swissprot:DGTP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DGTP_ECOLI inforesidue swissprot:DGTP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DGTP_ECOLI octanol swissprot:DGTP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DGTP_ECOLI pepcoil swissprot:DGTP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DGTP_ECOLI pepdigest swissprot:DGTP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DGTP_ECOLI pepinfo swissprot:DGTP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DGTP_ECOLI pepnet swissprot:DGTP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DGTP_ECOLI pepstats swissprot:DGTP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DGTP_ECOLI pepwheel swissprot:DGTP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DGTP_ECOLI pepwindow swissprot:DGTP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DGTP_ECOLI sigcleave swissprot:DGTP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DGTP_ECOLI ## Database ID URL or Descriptions # AltName LPXC_ECOLI UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase {ECO 0000255|HAMAP-Rule MF_00388, ECO 0000303|PubMed 8824222} # AltName Protein EnvA {ECO 0000305} # BIOPHYSICOCHEMICAL PROPERTIES LPXC_ECOLI Kinetic parameters KM=2.1 uM for UDP-3-O-myristoyl-N-acetylglucosamine (at 30 degrees Celsius) {ECO 0000269|PubMed 10026271}; KM=0.6 uM for UDP-3-O-myristoyl-N-acetylglucosamine (at 1 degree Celsius) {ECO 0000269|PubMed 10026271}; Note=kcat is 3.3 sec(-1) at 30 degrees Celsius. kcat is 0.09 sec(-1) at 1 degree Celsius. {ECO 0000269|PubMed 10026271}; # BioGrid 4261858 357 # CATALYTIC ACTIVITY LPXC_ECOLI UDP-3-O-((3R)-3-hydroxytetradecanoyl)-N- acetyl-alpha-D-glucosamine + H(2)O = UDP-3-O-((3R)-3- hydroxytetradecanoyl)-alpha-D-glucosamine + acetate. {ECO 0000255|HAMAP-Rule MF_00388, ECO 0000269|PubMed 10026271, ECO 0000269|PubMed 11148046, ECO 0000269|PubMed 15705580, ECO 0000269|PubMed 8530464, ECO 0000269|PubMed 8824222}. # COFACTOR LPXC_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000255|HAMAP-Rule MF_00388, ECO 0000269|PubMed 10026271, ECO 0000269|PubMed 20709752}; Name=Fe(2+); Xref=ChEBI CHEBI 29033; Evidence={ECO 0000269|PubMed 20136146, ECO 0000269|PubMed 20709752}; Note=Can use either Fe(2+) or Zn(2+). The metal cofactor can switch between Fe(2+) and Zn(2+) in response to metal availability. Metal switching may be important for regulating the LpxC activity upon changes in environmental conditions. Has a significantly higher affinity for Zn(2+), but exhibits higher activity with Fe(2+) (PubMed 20136146, PubMed 20709752). Can also use Co(2+), Ni(2+) and, to a lesser extent, Mn(2+) (PubMed 10026271). {ECO 0000269|PubMed 10026271, ECO 0000269|PubMed 20136146, ECO 0000269|PubMed 20709752}; # DOMAIN LPXC_ECOLI The N-terminus is required for deacetylase activity. The C-terminus contains a signal sequence necessary for FtsH-dependent degradation. {ECO 0000269|PubMed 16420369}. # ENZYME REGULATION LPXC_ECOLI Regulation occurs at the protein level, via degradation of LpxC by the FtsH protease (PubMed 10048027, PubMed 16420369, PubMed 21193611, PubMed 23417489). Degradation is growth rate-dependent. LpxC is degraded rapidly during slow growth, probably to avoid toxic overproduction of lipopolysaccharides, but is highly stable under optimal growth conditions (PubMed 23417489). Increased amounts of LpxC are made under conditions that reduce the lipid A content of cells (PubMed 8824222). Inhibited by metal chelators such as EDTA and dipicolinic acid (DPA) and by high concentrations of Zn(2+) (PubMed 10026271). {ECO 0000269|PubMed 10026271, ECO 0000269|PubMed 10048027, ECO 0000269|PubMed 16420369, ECO 0000269|PubMed 21193611, ECO 0000269|PubMed 23417489, ECO 0000269|PubMed 8824222}. # EcoGene EG10265 lpxC # FUNCTION LPXC_ECOLI Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis. {ECO 0000255|HAMAP-Rule MF_00388, ECO 0000269|PubMed 10026271, ECO 0000269|PubMed 8530464, ECO 0000269|PubMed 8824222, ECO 0000269|Ref.7}. # GO_component GO:0005737 cytoplasm; IDA:EcoCyc. # GO_function GO:0005506 iron ion binding; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_function GO:0008759 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity; IDA:EcoCyc. # GO_function GO:0019213 deacetylase activity; IDA:EcoliWiki. # GO_function GO:0103117 UDP-3-O-acyl-N-acetylglucosamine deacetylase activity; IEA:UniProtKB-EC. # GO_process GO:0009245 lipid A biosynthetic process; IMP:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.30.1700.10 -; 1. # Gene3D 3.30.230.20 -; 1. # HAMAP MF_00388 LpxC # IntAct P0A725 5 # InterPro IPR004463 UDP-acyl_GlcNac_deAcase # InterPro IPR011334 UDP-acyl_GlcNac_deAcase_C # InterPro IPR015870 UDP-acyl_N-AcGlcN_deAcase_N # InterPro IPR020568 Ribosomal_S5_D2-typ_fold # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # KEGG_Pathway ko00540 Lipopolysaccharide biosynthesis # MISCELLANEOUS LPXC_ECOLI Due to its important role in lipid A synthesis, LpxC is an attractive target for the development of new antibacterial agents to treat Gram-negative infections. Many potent LpxC inhibitors with a variety of chemical scaffolds and distinct antibiotic profiles have been discovered. {ECO 0000269|PubMed 18289052, ECO 0000269|PubMed 20019290, ECO 0000269|PubMed 24117400}. # Organism LPXC_ECOLI Escherichia coli (strain K12) # PATHWAY LPXC_ECOLI Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine step 2/6. {ECO 0000255|HAMAP- Rule MF_00388, ECO 0000269|PubMed 8530464}. # PATRIC 32115297 VBIEscCol129921_0100 # PDB 4IS9 X-ray; 2.13 A; A/B=1-300 # PDB 4ISA X-ray; 1.80 A; A=1-300 # PDB 4MDT X-ray; 2.59 A; A/B/C/D=1-305 # PDB 4MQY X-ray; 2.00 A; A=1-305 # PIR A28381 BVECEA # PTM LPXC_ECOLI Degraded by FtsH. {ECO 0000269|PubMed 10048027, ECO 0000269|PubMed 16420369, ECO 0000269|PubMed 21193611, ECO 0000269|PubMed 23417489}. # Pfam PF03331 LpxC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LPXC_ECOLI UDP-3-O-acyl-N-acetylglucosamine deacetylase {ECO 0000255|HAMAP-Rule MF_00388, ECO 0000303|PubMed 8530464} # RefSeq NP_414638 NC_000913.3 # RefSeq WP_000595482 NZ_LN832404.1 # SIMILARITY Belongs to the LpxC family. {ECO:0000255|HAMAP- Rule MF_00388}. # SUPFAM SSF54211 SSF54211; 2 # TIGRFAMs TIGR00325 lpxC # UniPathway UPA00359 UER00478 # eggNOG COG0774 LUCA # eggNOG ENOG4105C7C Bacteria BLAST swissprot:LPXC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LPXC_ECOLI BioCyc ECOL316407:JW0094-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0094-MONOMER BioCyc EcoCyc:UDPACYLGLCNACDEACETYL-MONOMER http://biocyc.org/getid?id=EcoCyc:UDPACYLGLCNACDEACETYL-MONOMER BioCyc MetaCyc:UDPACYLGLCNACDEACETYL-MONOMER http://biocyc.org/getid?id=MetaCyc:UDPACYLGLCNACDEACETYL-MONOMER COG COG0774 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0774 DIP DIP-48045N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48045N DOI 10.1016/0378-1119(85)90179-9 http://dx.doi.org/10.1016/0378-1119(85)90179-9 DOI 10.1021/bi001872g http://dx.doi.org/10.1021/bi001872g DOI 10.1021/bi902066t http://dx.doi.org/10.1021/bi902066t DOI 10.1021/bi982339s http://dx.doi.org/10.1021/bi982339s DOI 10.1021/cb400067g http://dx.doi.org/10.1021/cb400067g DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1999.01221.x http://dx.doi.org/10.1046/j.1365-2958.1999.01221.x DOI 10.1074/jbc.270.51.30384 http://dx.doi.org/10.1074/jbc.270.51.30384 DOI 10.1074/jbc.271.42.25898 http://dx.doi.org/10.1074/jbc.271.42.25898 DOI 10.1074/jbc.M110.147173 http://dx.doi.org/10.1074/jbc.M110.147173 DOI 10.1074/jbc.M113.513028 http://dx.doi.org/10.1074/jbc.M113.513028 DOI 10.1074/jbc.M413560200 http://dx.doi.org/10.1074/jbc.M413560200 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1111/j.1365-2958.2005.04994.x http://dx.doi.org/10.1111/j.1365-2958.2005.04994.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01043-10 http://dx.doi.org/10.1128/JB.01043-10 DOI 10.1128/JB.02134-12 http://dx.doi.org/10.1128/JB.02134-12 DOI 10.1177/1087057109355319 http://dx.doi.org/10.1177/1087057109355319 DOI 10.2174/138920108783497668 http://dx.doi.org/10.2174/138920108783497668 EC_number EC:3.5.1.108 {ECO:0000255|HAMAP-Rule:MF_00388, ECO:0000269|PubMed:10026271, ECO:0000269|PubMed:11148046, ECO:0000269|PubMed:15705580, ECO:0000269|PubMed:8530464, ECO:0000269|PubMed:8824222} http://www.genome.jp/dbget-bin/www_bget?EC:3.5.1.108 {ECO:0000255|HAMAP-Rule:MF_00388, ECO:0000269|PubMed:10026271, ECO:0000269|PubMed:11148046, ECO:0000269|PubMed:15705580, ECO:0000269|PubMed:8530464, ECO:0000269|PubMed:8824222} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M19211 http://www.ebi.ac.uk/ena/data/view/M19211 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X55034 http://www.ebi.ac.uk/ena/data/view/X55034 ENZYME 3.5.1.108 {ECO:0000255|HAMAP-Rule:MF_00388, ECO:0000269|PubMed:10026271, ECO:0000269|PubMed:11148046, ECO:0000269|PubMed:15705580, ECO:0000269|PubMed:8530464, ECO:0000269|PubMed:8824222} http://enzyme.expasy.org/EC/3.5.1.108 {ECO:0000255|HAMAP-Rule:MF_00388, ECO:0000269|PubMed:10026271, ECO:0000269|PubMed:11148046, ECO:0000269|PubMed:15705580, ECO:0000269|PubMed:8530464, ECO:0000269|PubMed:8824222} EchoBASE EB0261 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0261 EcoGene EG10265 http://www.ecogene.org/geneInfo.php?eg_id=EG10265 EnsemblBacteria AAC73207 http://www.ensemblgenomes.org/id/AAC73207 EnsemblBacteria AAC73207 http://www.ensemblgenomes.org/id/AAC73207 EnsemblBacteria BAB96664 http://www.ensemblgenomes.org/id/BAB96664 EnsemblBacteria BAB96664 http://www.ensemblgenomes.org/id/BAB96664 EnsemblBacteria BAB96664 http://www.ensemblgenomes.org/id/BAB96664 EnsemblBacteria b0096 http://www.ensemblgenomes.org/id/b0096 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0008759 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008759 GO_function GO:0019213 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019213 GO_function GO:0103117 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0103117 GO_process GO:0009245 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009245 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016810 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.30.1700.10 http://www.cathdb.info/version/latest/superfamily/3.30.1700.10 Gene3D 3.30.230.20 http://www.cathdb.info/version/latest/superfamily/3.30.230.20 GeneID 944816 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944816 HAMAP MF_00388 http://hamap.expasy.org/unirule/MF_00388 HOGENOM HOG000256663 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000256663&db=HOGENOM6 InParanoid P0A725 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A725 IntAct P0A725 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A725* IntEnz 3.5.1.108 {ECO:0000255|HAMAP-Rule:MF_00388, ECO:0000269|PubMed:10026271, ECO:0000269|PubMed:11148046, ECO:0000269|PubMed:15705580, ECO:0000269|PubMed:8530464, ECO:0000269|PubMed:8824222} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.5.1.108 {ECO:0000255|HAMAP-Rule:MF_00388, ECO:0000269|PubMed:10026271, ECO:0000269|PubMed:11148046, ECO:0000269|PubMed:15705580, ECO:0000269|PubMed:8530464, ECO:0000269|PubMed:8824222} InterPro IPR004463 http://www.ebi.ac.uk/interpro/entry/IPR004463 InterPro IPR011334 http://www.ebi.ac.uk/interpro/entry/IPR011334 InterPro IPR015870 http://www.ebi.ac.uk/interpro/entry/IPR015870 InterPro IPR020568 http://www.ebi.ac.uk/interpro/entry/IPR020568 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Gene ecj:JW0094 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0094 KEGG_Gene eco:b0096 http://www.genome.jp/dbget-bin/www_bget?eco:b0096 KEGG_Orthology KO:K02535 http://www.genome.jp/dbget-bin/www_bget?KO:K02535 KEGG_Pathway ko00540 http://www.genome.jp/kegg-bin/show_pathway?ko00540 KEGG_Reaction rn:R04587 http://www.genome.jp/dbget-bin/www_bget?rn:R04587 MINT MINT-1309717 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1309717 OMA NSMLVKA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NSMLVKA PDB 4IS9 http://www.ebi.ac.uk/pdbe-srv/view/entry/4IS9 PDB 4ISA http://www.ebi.ac.uk/pdbe-srv/view/entry/4ISA PDB 4MDT http://www.ebi.ac.uk/pdbe-srv/view/entry/4MDT PDB 4MQY http://www.ebi.ac.uk/pdbe-srv/view/entry/4MQY PDBsum 4IS9 http://www.ebi.ac.uk/pdbsum/4IS9 PDBsum 4ISA http://www.ebi.ac.uk/pdbsum/4ISA PDBsum 4MDT http://www.ebi.ac.uk/pdbsum/4MDT PDBsum 4MQY http://www.ebi.ac.uk/pdbsum/4MQY PSORT swissprot:LPXC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LPXC_ECOLI PSORT-B swissprot:LPXC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LPXC_ECOLI PSORT2 swissprot:LPXC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LPXC_ECOLI Pfam PF03331 http://pfam.xfam.org/family/PF03331 Phobius swissprot:LPXC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LPXC_ECOLI PhylomeDB P0A725 http://phylomedb.org/?seqid=P0A725 ProteinModelPortal P0A725 http://www.proteinmodelportal.org/query/uniprot/P0A725 PubMed 10026271 http://www.ncbi.nlm.nih.gov/pubmed/10026271 PubMed 10048027 http://www.ncbi.nlm.nih.gov/pubmed/10048027 PubMed 11148046 http://www.ncbi.nlm.nih.gov/pubmed/11148046 PubMed 15705580 http://www.ncbi.nlm.nih.gov/pubmed/15705580 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16420369 http://www.ncbi.nlm.nih.gov/pubmed/16420369 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18289052 http://www.ncbi.nlm.nih.gov/pubmed/18289052 PubMed 20019290 http://www.ncbi.nlm.nih.gov/pubmed/20019290 PubMed 20136146 http://www.ncbi.nlm.nih.gov/pubmed/20136146 PubMed 20709752 http://www.ncbi.nlm.nih.gov/pubmed/20709752 PubMed 21193611 http://www.ncbi.nlm.nih.gov/pubmed/21193611 PubMed 23417489 http://www.ncbi.nlm.nih.gov/pubmed/23417489 PubMed 24108127 http://www.ncbi.nlm.nih.gov/pubmed/24108127 PubMed 24117400 http://www.ncbi.nlm.nih.gov/pubmed/24117400 PubMed 2824434 http://www.ncbi.nlm.nih.gov/pubmed/2824434 PubMed 3000876 http://www.ncbi.nlm.nih.gov/pubmed/3000876 PubMed 8530464 http://www.ncbi.nlm.nih.gov/pubmed/8530464 PubMed 8752330 http://www.ncbi.nlm.nih.gov/pubmed/8752330 PubMed 8824222 http://www.ncbi.nlm.nih.gov/pubmed/8824222 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414638 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414638 RefSeq WP_000595482 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000595482 SMR P0A725 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A725 STRING 511145.b0096 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0096&targetmode=cogs STRING COG0774 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0774&targetmode=cogs SUPFAM SSF54211 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54211 TIGRFAMs TIGR00325 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00325 UniProtKB LPXC_ECOLI http://www.uniprot.org/uniprot/LPXC_ECOLI UniProtKB-AC P0A725 http://www.uniprot.org/uniprot/P0A725 charge swissprot:LPXC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LPXC_ECOLI eggNOG COG0774 http://eggnogapi.embl.de/nog_data/html/tree/COG0774 eggNOG ENOG4105C7C http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C7C epestfind swissprot:LPXC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LPXC_ECOLI garnier swissprot:LPXC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LPXC_ECOLI helixturnhelix swissprot:LPXC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LPXC_ECOLI hmoment swissprot:LPXC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LPXC_ECOLI iep swissprot:LPXC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LPXC_ECOLI inforesidue swissprot:LPXC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LPXC_ECOLI octanol swissprot:LPXC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LPXC_ECOLI pepcoil swissprot:LPXC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LPXC_ECOLI pepdigest swissprot:LPXC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LPXC_ECOLI pepinfo swissprot:LPXC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LPXC_ECOLI pepnet swissprot:LPXC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LPXC_ECOLI pepstats swissprot:LPXC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LPXC_ECOLI pepwheel swissprot:LPXC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LPXC_ECOLI pepwindow swissprot:LPXC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LPXC_ECOLI sigcleave swissprot:LPXC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LPXC_ECOLI ## Database ID URL or Descriptions # AltName RHAB_ECOLI ATP L-rhamnulose phosphotransferase {ECO 0000255|HAMAP-Rule MF_01535, ECO 0000303|PubMed 14264882} # AltName RHAB_ECOLI L-rhamnulose 1-kinase {ECO 0000255|HAMAP-Rule MF_01535, ECO 0000303|PubMed 16674975} # AltName RHAB_ECOLI Rhamnulose kinase {ECO 0000255|HAMAP-Rule MF_01535, ECO 0000303|PubMed 8396120} # BIOPHYSICOCHEMICAL PROPERTIES RHAB_ECOLI Kinetic parameters KM=82 uM for L-rhamnulose (at pH 8.5 and 37 degrees Celsius) {ECO 0000269|PubMed 14264882}; KM=110 uM for ATP (at pH 8.5 and 37 degrees Celsius) {ECO 0000269|PubMed 14264882}; KM=270 uM for magnesium ion (at pH 8.5 and 37 degrees Celsius) {ECO 0000269|PubMed 14264882}; KM=3 mM for beta-L-fructose (at pH 8) {ECO 0000269|PubMed 16674975}; pH dependence Optimum pH is 8.5. {ECO 0000269|PubMed 14264882}; # BRENDA 2.7.1 2026 # CATALYTIC ACTIVITY RHAB_ECOLI ATP + L-rhamnulose = ADP + L-rhamnulose 1- phosphate. {ECO 0000255|HAMAP-Rule MF_01535, ECO 0000269|PubMed 14264882, ECO 0000269|PubMed 16674975}. # COFACTOR RHAB_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_01535, ECO 0000269|PubMed 14264882}; Note=It can also use manganese, cobalt, iron, calcium and copper ions. {ECO 0000269|PubMed 14264882}; # DISRUPTION PHENOTYPE Cells lacking this gene are unable to utilize rhamnose as a source of carbon. {ECO:0000269|PubMed 5341476}. # EcoGene EG11868 rhaB # FUNCTION RHAB_ECOLI Involved in the catabolism of L-rhamnose (6-deoxy-L- mannose). It could also play a role in the metabolism of some rare sugars such as L-fructose. Catalyzes the transfer of the gamma- phosphate group from ATP to the 1-hydroxyl group of L-rhamnulose to yield L-rhamnulose 1-phosphate. Uridine triphosphate (UTP), cytidine 5-triphosphate (CTP), guanosine 5-triphosphate (GTP), and thymidine triphosphate (TTP) also can act as phosphoryl donors. It can also phosphorylate L-fuculose and L-xylulose. {ECO 0000255|HAMAP-Rule MF_01535, ECO 0000269|PubMed 14264882, ECO 0000269|PubMed 16674975, ECO 0000269|PubMed 5341476}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0005524 ATP binding; IDA:UniProtKB. # GO_function GO:0008993 rhamnulokinase activity; IDA:UniProtKB. # GO_process GO:0019301 rhamnose catabolic process; IDA:UniProtKB. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # HAMAP MF_01535 Rhamnulokinase # INDUCTION RHAB_ECOLI Induced by L-rhamnose via the RhaR-RhaS regulatory cascade. Binding of the cAMP receptor protein (CRP) is required for full expression. Also induced by L-lyxose. {ECO 0000269|PubMed 10852886, ECO 0000269|PubMed 1650346, ECO 0000269|PubMed 8230210}. # IntAct P32171 2 # InterPro IPR013449 Rhamnulokinase # InterPro IPR018484 Carb_kinase_FGGY_N # InterPro IPR018485 Carb_kinase_FGGY_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00040 Pentose and glucuronate interconversions # KEGG_Pathway ko00051 Fructose and mannose metabolism # Organism RHAB_ECOLI Escherichia coli (strain K12) # PATHWAY Carbohydrate degradation; L-rhamnose degradation; glycerone phosphate from L-rhamnose: step 2/3. {ECO 0000255|HAMAP- Rule:MF_01535}. # PATRIC 32123317 VBIEscCol129921_4019 # PDB 2CGJ X-ray; 2.26 A; A=1-489 # PDB 2CGK X-ray; 2.46 A; A/B=1-489 # PDB 2CGL X-ray; 1.88 A; A=1-489 # PIR S40848 S40848 # Pfam PF00370 FGGY_N # Pfam PF02782 FGGY_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RHAB_ECOLI L-Rhamnulokinase {ECO 0000255|HAMAP-Rule MF_01535, ECO 0000303|PubMed 8396120} # RefSeq NP_418340 NC_000913.3 # RefSeq WP_000144073 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA43001.1; Type=Frameshift; Positions=398; Evidence={ECO 0000305}; # SIMILARITY Belongs to the rhamnulokinase family. {ECO:0000255|HAMAP-Rule MF_01535}. # SUBUNIT RHAB_ECOLI Monomer. {ECO 0000255|HAMAP-Rule MF_01535, ECO 0000269|PubMed 16674975}. # TIGRFAMs TIGR02627 rhamnulo_kin # UniPathway UPA00541 UER00602 # eggNOG COG1070 LUCA # eggNOG ENOG4105DET Bacteria BLAST swissprot:RHAB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RHAB_ECOLI BioCyc ECOL316407:JW3875-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3875-MONOMER BioCyc EcoCyc:RHAMNULOKIN-MONOMER http://biocyc.org/getid?id=EcoCyc:RHAMNULOKIN-MONOMER BioCyc MetaCyc:RHAMNULOKIN-MONOMER http://biocyc.org/getid?id=MetaCyc:RHAMNULOKIN-MONOMER COG COG1070 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1070 DOI 10.1006/jmbi.1993.1565 http://dx.doi.org/10.1006/jmbi.1993.1565 DOI 10.1016/j.jmb.2006.04.013 http://dx.doi.org/10.1016/j.jmb.2006.04.013 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.12.3529-3535.2000 http://dx.doi.org/10.1128/JB.182.12.3529-3535.2000 EC_number EC:2.7.1.5 {ECO:0000255|HAMAP-Rule:MF_01535, ECO:0000269|PubMed:14264882, ECO:0000269|PubMed:16674975} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.5 {ECO:0000255|HAMAP-Rule:MF_01535, ECO:0000269|PubMed:14264882, ECO:0000269|PubMed:16674975} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X60472 http://www.ebi.ac.uk/ena/data/view/X60472 ENZYME 2.7.1.5 {ECO:0000255|HAMAP-Rule:MF_01535, ECO:0000269|PubMed:14264882, ECO:0000269|PubMed:16674975} http://enzyme.expasy.org/EC/2.7.1.5 {ECO:0000255|HAMAP-Rule:MF_01535, ECO:0000269|PubMed:14264882, ECO:0000269|PubMed:16674975} EchoBASE EB1814 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1814 EcoGene EG11868 http://www.ecogene.org/geneInfo.php?eg_id=EG11868 EnsemblBacteria AAC76886 http://www.ensemblgenomes.org/id/AAC76886 EnsemblBacteria AAC76886 http://www.ensemblgenomes.org/id/AAC76886 EnsemblBacteria BAE77405 http://www.ensemblgenomes.org/id/BAE77405 EnsemblBacteria BAE77405 http://www.ensemblgenomes.org/id/BAE77405 EnsemblBacteria BAE77405 http://www.ensemblgenomes.org/id/BAE77405 EnsemblBacteria b3904 http://www.ensemblgenomes.org/id/b3904 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008993 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008993 GO_process GO:0019301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019301 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 948399 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948399 HAMAP MF_01535 http://hamap.expasy.org/unirule/MF_01535 HOGENOM HOG000250110 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000250110&db=HOGENOM6 InParanoid P32171 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32171 IntAct P32171 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32171* IntEnz 2.7.1.5 {ECO:0000255|HAMAP-Rule:MF_01535, ECO:0000269|PubMed:14264882, ECO:0000269|PubMed:16674975} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.5 {ECO:0000255|HAMAP-Rule:MF_01535, ECO:0000269|PubMed:14264882, ECO:0000269|PubMed:16674975} InterPro IPR013449 http://www.ebi.ac.uk/interpro/entry/IPR013449 InterPro IPR018484 http://www.ebi.ac.uk/interpro/entry/IPR018484 InterPro IPR018485 http://www.ebi.ac.uk/interpro/entry/IPR018485 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3875 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3875 KEGG_Gene eco:b3904 http://www.genome.jp/dbget-bin/www_bget?eco:b3904 KEGG_Orthology KO:K00848 http://www.genome.jp/dbget-bin/www_bget?KO:K00848 KEGG_Pathway ko00040 http://www.genome.jp/kegg-bin/show_pathway?ko00040 KEGG_Pathway ko00051 http://www.genome.jp/kegg-bin/show_pathway?ko00051 KEGG_Reaction rn:R01902 http://www.genome.jp/dbget-bin/www_bget?rn:R01902 KEGG_Reaction rn:R03014 http://www.genome.jp/dbget-bin/www_bget?rn:R03014 OMA HETREWT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HETREWT PDB 2CGJ http://www.ebi.ac.uk/pdbe-srv/view/entry/2CGJ PDB 2CGK http://www.ebi.ac.uk/pdbe-srv/view/entry/2CGK PDB 2CGL http://www.ebi.ac.uk/pdbe-srv/view/entry/2CGL PDBsum 2CGJ http://www.ebi.ac.uk/pdbsum/2CGJ PDBsum 2CGK http://www.ebi.ac.uk/pdbsum/2CGK PDBsum 2CGL http://www.ebi.ac.uk/pdbsum/2CGL PSORT swissprot:RHAB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RHAB_ECOLI PSORT-B swissprot:RHAB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RHAB_ECOLI PSORT2 swissprot:RHAB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RHAB_ECOLI Pfam PF00370 http://pfam.xfam.org/family/PF00370 Pfam PF02782 http://pfam.xfam.org/family/PF02782 Phobius swissprot:RHAB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RHAB_ECOLI PhylomeDB P32171 http://phylomedb.org/?seqid=P32171 ProteinModelPortal P32171 http://www.proteinmodelportal.org/query/uniprot/P32171 PubMed 10852886 http://www.ncbi.nlm.nih.gov/pubmed/10852886 PubMed 14264882 http://www.ncbi.nlm.nih.gov/pubmed/14264882 PubMed 1650346 http://www.ncbi.nlm.nih.gov/pubmed/1650346 PubMed 16674975 http://www.ncbi.nlm.nih.gov/pubmed/16674975 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 5341476 http://www.ncbi.nlm.nih.gov/pubmed/5341476 PubMed 8230210 http://www.ncbi.nlm.nih.gov/pubmed/8230210 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 8396120 http://www.ncbi.nlm.nih.gov/pubmed/8396120 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418340 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418340 RefSeq WP_000144073 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000144073 SMR P32171 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32171 STRING 511145.b3904 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3904&targetmode=cogs STRING COG1070 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1070&targetmode=cogs TIGRFAMs TIGR02627 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02627 UniProtKB RHAB_ECOLI http://www.uniprot.org/uniprot/RHAB_ECOLI UniProtKB-AC P32171 http://www.uniprot.org/uniprot/P32171 charge swissprot:RHAB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RHAB_ECOLI eggNOG COG1070 http://eggnogapi.embl.de/nog_data/html/tree/COG1070 eggNOG ENOG4105DET http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DET epestfind swissprot:RHAB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RHAB_ECOLI garnier swissprot:RHAB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RHAB_ECOLI helixturnhelix swissprot:RHAB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RHAB_ECOLI hmoment swissprot:RHAB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RHAB_ECOLI iep swissprot:RHAB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RHAB_ECOLI inforesidue swissprot:RHAB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RHAB_ECOLI octanol swissprot:RHAB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RHAB_ECOLI pepcoil swissprot:RHAB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RHAB_ECOLI pepdigest swissprot:RHAB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RHAB_ECOLI pepinfo swissprot:RHAB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RHAB_ECOLI pepnet swissprot:RHAB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RHAB_ECOLI pepstats swissprot:RHAB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RHAB_ECOLI pepwheel swissprot:RHAB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RHAB_ECOLI pepwindow swissprot:RHAB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RHAB_ECOLI sigcleave swissprot:RHAB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RHAB_ECOLI ## Database ID URL or Descriptions # BioGrid 4261523 4 # EcoGene EG13584 ykgG # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # Gene3D 3.40.50.10420 -; 1. # InterPro IPR003741 LUD_dom # InterPro IPR024185 FTHF_cligase-like # MISCELLANEOUS YKGG_ECOLI The E.coli ykgEFG operon is a clear homolog of the B.subtilis lutABC operon, however it is not able of restoring L- lactate utilization to the B.subtilis mutant for lutABC operon. Thus, ykgEFG operon may contribute to lactate catabolism in E.coli, but under conditions other than those tested, or alternatively, the ykgEFG operon may be responsible for the catabolism of a metabolite other than (but perhaps related to) lactate in E.coli. # Organism YKGG_ECOLI Escherichia coli (strain K12) # PATRIC 32115747 VBIEscCol129921_0316 # PIR D64757 D64757 # Pfam PF02589 LUD_dom # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YKGG_ECOLI Uncharacterized protein YkgG # RefSeq NP_414842 NC_000913.3 # RefSeq WP_000370307 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18035.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the LutC/YkgG family. {ECO 0000305}. # eggNOG COG1556 LUCA # eggNOG ENOG4108ZZK Bacteria BLAST swissprot:YKGG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YKGG_ECOLI BioCyc ECOL316407:JW5042-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5042-MONOMER BioCyc EcoCyc:G6178-MONOMER http://biocyc.org/getid?id=EcoCyc:G6178-MONOMER COG COG1556 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1556 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01464-08 http://dx.doi.org/10.1128/JB.01464-08 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB3354 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3354 EcoGene EG13584 http://www.ecogene.org/geneInfo.php?eg_id=EG13584 EnsemblBacteria AAC73411 http://www.ensemblgenomes.org/id/AAC73411 EnsemblBacteria AAC73411 http://www.ensemblgenomes.org/id/AAC73411 EnsemblBacteria BAE76092 http://www.ensemblgenomes.org/id/BAE76092 EnsemblBacteria BAE76092 http://www.ensemblgenomes.org/id/BAE76092 EnsemblBacteria BAE76092 http://www.ensemblgenomes.org/id/BAE76092 EnsemblBacteria b0308 http://www.ensemblgenomes.org/id/b0308 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 Gene3D 3.40.50.10420 http://www.cathdb.info/version/latest/superfamily/3.40.50.10420 GeneID 945906 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945906 HOGENOM HOG000086052 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000086052&db=HOGENOM6 InParanoid P77433 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77433 InterPro IPR003741 http://www.ebi.ac.uk/interpro/entry/IPR003741 InterPro IPR024185 http://www.ebi.ac.uk/interpro/entry/IPR024185 KEGG_Gene ecj:JW5042 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5042 KEGG_Gene eco:b0308 http://www.genome.jp/dbget-bin/www_bget?eco:b0308 KEGG_Orthology KO:K00782 http://www.genome.jp/dbget-bin/www_bget?KO:K00782 OMA SCVNIIS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SCVNIIS PSORT swissprot:YKGG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YKGG_ECOLI PSORT-B swissprot:YKGG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YKGG_ECOLI PSORT2 swissprot:YKGG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YKGG_ECOLI Pfam PF02589 http://pfam.xfam.org/family/PF02589 Phobius swissprot:YKGG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YKGG_ECOLI PhylomeDB P77433 http://phylomedb.org/?seqid=P77433 ProteinModelPortal P77433 http://www.proteinmodelportal.org/query/uniprot/P77433 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19201793 http://www.ncbi.nlm.nih.gov/pubmed/19201793 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414842 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414842 RefSeq WP_000370307 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000370307 SMR P77433 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77433 STRING 511145.b0308 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0308&targetmode=cogs STRING COG1556 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1556&targetmode=cogs UniProtKB YKGG_ECOLI http://www.uniprot.org/uniprot/YKGG_ECOLI UniProtKB-AC P77433 http://www.uniprot.org/uniprot/P77433 charge swissprot:YKGG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YKGG_ECOLI eggNOG COG1556 http://eggnogapi.embl.de/nog_data/html/tree/COG1556 eggNOG ENOG4108ZZK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZZK epestfind swissprot:YKGG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YKGG_ECOLI garnier swissprot:YKGG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YKGG_ECOLI helixturnhelix swissprot:YKGG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YKGG_ECOLI hmoment swissprot:YKGG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YKGG_ECOLI iep swissprot:YKGG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YKGG_ECOLI inforesidue swissprot:YKGG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YKGG_ECOLI octanol swissprot:YKGG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YKGG_ECOLI pepcoil swissprot:YKGG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YKGG_ECOLI pepdigest swissprot:YKGG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YKGG_ECOLI pepinfo swissprot:YKGG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YKGG_ECOLI pepnet swissprot:YKGG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YKGG_ECOLI pepstats swissprot:YKGG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YKGG_ECOLI pepwheel swissprot:YKGG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YKGG_ECOLI pepwindow swissprot:YKGG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YKGG_ECOLI sigcleave swissprot:YKGG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YKGG_ECOLI ## Database ID URL or Descriptions # BioGrid 4260356 203 # EcoGene EG14021 yebS # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0009408 response to heat; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006950 response to stress # IntAct P0AD03 2 # InterPro IPR005219 CHP00155 # InterPro IPR007498 PqiA # InterPro IPR011031 Multihaem_cyt # Organism YEBS_ECOLI Escherichia coli (strain K12) # PATRIC 32118987 VBIEscCol129921_1911 # PIR A64945 A64945 # PROSITE PS51008 MULTIHEME_CYTC # Pfam PF04403 PqiA; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEBS_ECOLI Inner membrane protein YebS # RefSeq NP_416347 NC_000913.3 # RefSeq WP_001207282 NZ_LN832404.1 # SIMILARITY Belongs to the PqiA family. {ECO 0000305}. # SUBCELLULAR LOCATION YEBS_ECOLI Cell inner membrane; Multi-pass membrane protein. # TIGRFAMs TIGR00155 pqiA_fam # eggNOG COG2995 LUCA # eggNOG ENOG4105H2K Bacteria BLAST swissprot:YEBS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEBS_ECOLI BioCyc ECOL316407:JW1822-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1822-MONOMER BioCyc EcoCyc:G7006-MONOMER http://biocyc.org/getid?id=EcoCyc:G7006-MONOMER COG COG2995 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2995 DIP DIP-48172N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48172N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3775 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3775 EcoGene EG14021 http://www.ecogene.org/geneInfo.php?eg_id=EG14021 EnsemblBacteria AAC74903 http://www.ensemblgenomes.org/id/AAC74903 EnsemblBacteria AAC74903 http://www.ensemblgenomes.org/id/AAC74903 EnsemblBacteria BAA15641 http://www.ensemblgenomes.org/id/BAA15641 EnsemblBacteria BAA15641 http://www.ensemblgenomes.org/id/BAA15641 EnsemblBacteria BAA15641 http://www.ensemblgenomes.org/id/BAA15641 EnsemblBacteria b1833 http://www.ensemblgenomes.org/id/b1833 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 946353 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946353 HOGENOM HOG000283617 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000283617&db=HOGENOM6 IntAct P0AD03 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AD03* InterPro IPR005219 http://www.ebi.ac.uk/interpro/entry/IPR005219 InterPro IPR007498 http://www.ebi.ac.uk/interpro/entry/IPR007498 InterPro IPR011031 http://www.ebi.ac.uk/interpro/entry/IPR011031 KEGG_Gene ecj:JW1822 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1822 KEGG_Gene eco:b1833 http://www.genome.jp/dbget-bin/www_bget?eco:b1833 KEGG_Orthology KO:K03808 http://www.genome.jp/dbget-bin/www_bget?KO:K03808 OMA PISIIYV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PISIIYV PROSITE PS51008 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51008 PSORT swissprot:YEBS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEBS_ECOLI PSORT-B swissprot:YEBS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEBS_ECOLI PSORT2 swissprot:YEBS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEBS_ECOLI Pfam PF04403 http://pfam.xfam.org/family/PF04403 Phobius swissprot:YEBS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEBS_ECOLI PhylomeDB P0AD03 http://phylomedb.org/?seqid=P0AD03 ProteinModelPortal P0AD03 http://www.proteinmodelportal.org/query/uniprot/P0AD03 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416347 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416347 RefSeq WP_001207282 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001207282 STRING 511145.b1833 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1833&targetmode=cogs STRING COG2995 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2995&targetmode=cogs TIGRFAMs TIGR00155 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00155 UniProtKB YEBS_ECOLI http://www.uniprot.org/uniprot/YEBS_ECOLI UniProtKB-AC P0AD03 http://www.uniprot.org/uniprot/P0AD03 charge swissprot:YEBS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEBS_ECOLI eggNOG COG2995 http://eggnogapi.embl.de/nog_data/html/tree/COG2995 eggNOG ENOG4105H2K http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105H2K epestfind swissprot:YEBS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEBS_ECOLI garnier swissprot:YEBS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEBS_ECOLI helixturnhelix swissprot:YEBS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEBS_ECOLI hmoment swissprot:YEBS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEBS_ECOLI iep swissprot:YEBS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEBS_ECOLI inforesidue swissprot:YEBS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEBS_ECOLI octanol swissprot:YEBS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEBS_ECOLI pepcoil swissprot:YEBS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEBS_ECOLI pepdigest swissprot:YEBS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEBS_ECOLI pepinfo swissprot:YEBS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEBS_ECOLI pepnet swissprot:YEBS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEBS_ECOLI pepstats swissprot:YEBS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEBS_ECOLI pepwheel swissprot:YEBS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEBS_ECOLI pepwindow swissprot:YEBS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEBS_ECOLI sigcleave swissprot:YEBS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEBS_ECOLI ## Database ID URL or Descriptions # BioGrid 4259461 11 # EcoGene EG12476 yjeN # IntAct P39283 5 # InterPro IPR020528 Uncharacterised_YjeN # Organism YJEN_ECOLI Escherichia coli (strain K12) # PATRIC 32123887 VBIEscCol129921_4291 # PIR S56385 S56385 # ProDom PD069398 Uncharacterised_YjeN # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJEN_ECOLI Uncharacterized protein YjeN # RefSeq NP_418581 NC_000913.3 # RefSeq WP_000342867 NZ_LN832404.1 # eggNOG ENOG4106V5W Bacteria # eggNOG ENOG410YPDD LUCA BLAST swissprot:YJEN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJEN_ECOLI BioCyc ECOL316407:JW4118-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4118-MONOMER BioCyc EcoCyc:G7838-MONOMER http://biocyc.org/getid?id=EcoCyc:G7838-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2369 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2369 EcoGene EG12476 http://www.ecogene.org/geneInfo.php?eg_id=EG12476 EnsemblBacteria AAC77117 http://www.ensemblgenomes.org/id/AAC77117 EnsemblBacteria AAC77117 http://www.ensemblgenomes.org/id/AAC77117 EnsemblBacteria BAE78161 http://www.ensemblgenomes.org/id/BAE78161 EnsemblBacteria BAE78161 http://www.ensemblgenomes.org/id/BAE78161 EnsemblBacteria BAE78161 http://www.ensemblgenomes.org/id/BAE78161 EnsemblBacteria b4157 http://www.ensemblgenomes.org/id/b4157 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 948678 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948678 HOGENOM HOG000127296 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000127296&db=HOGENOM6 IntAct P39283 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39283* InterPro IPR020528 http://www.ebi.ac.uk/interpro/entry/IPR020528 KEGG_Gene ecj:JW4118 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4118 KEGG_Gene eco:b4157 http://www.genome.jp/dbget-bin/www_bget?eco:b4157 PSORT swissprot:YJEN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJEN_ECOLI PSORT-B swissprot:YJEN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJEN_ECOLI PSORT2 swissprot:YJEN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJEN_ECOLI Phobius swissprot:YJEN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJEN_ECOLI ProteinModelPortal P39283 http://www.proteinmodelportal.org/query/uniprot/P39283 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418581 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418581 RefSeq WP_000342867 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000342867 STRING 511145.b4157 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4157&targetmode=cogs UniProtKB YJEN_ECOLI http://www.uniprot.org/uniprot/YJEN_ECOLI UniProtKB-AC P39283 http://www.uniprot.org/uniprot/P39283 charge swissprot:YJEN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJEN_ECOLI eggNOG ENOG4106V5W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106V5W eggNOG ENOG410YPDD http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YPDD epestfind swissprot:YJEN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJEN_ECOLI garnier swissprot:YJEN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJEN_ECOLI helixturnhelix swissprot:YJEN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJEN_ECOLI hmoment swissprot:YJEN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJEN_ECOLI iep swissprot:YJEN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJEN_ECOLI inforesidue swissprot:YJEN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJEN_ECOLI octanol swissprot:YJEN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJEN_ECOLI pepcoil swissprot:YJEN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJEN_ECOLI pepdigest swissprot:YJEN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJEN_ECOLI pepinfo swissprot:YJEN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJEN_ECOLI pepnet swissprot:YJEN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJEN_ECOLI pepstats swissprot:YJEN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJEN_ECOLI pepwheel swissprot:YJEN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJEN_ECOLI pepwindow swissprot:YJEN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJEN_ECOLI sigcleave swissprot:YJEN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJEN_ECOLI ## Database ID URL or Descriptions # AltName SGCA_ECOLI Putative PTS system EIIA component # BioGrid 4261489 8 # CATALYTIC ACTIVITY Protein EIIA N(pi)-phospho-L-histidine + protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L- histidine/cysteine. {ECO:0000255|PROSITE-ProRule PRU00417}. # DOMAIN SGCA_ECOLI The EIIA domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the EIIB domain. # EcoGene EG12554 sgcA # FUNCTION SGCA_ECOLI The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. {ECO 0000250}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0005215 transporter activity; IEA:InterPro. # GO_function GO:0016301 kinase activity; IEA:UniProtKB-KW. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016301 kinase activity # GOslim_process GO:0006810 transport # Gene3D 3.40.930.10 -; 1. # IntAct P39363 7 # InterPro IPR002178 PTS_EIIA_type-2_dom # InterPro IPR016152 PTrfase/Anion_transptr # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00279 PTS system, galactitol-specific II component # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko00052 Galactose metabolism # KEGG_Pathway ko02060 Phosphotransferase system (PTS) # Organism SGCA_ECOLI Escherichia coli (strain K12) # PATRIC 32124190 VBIEscCol129921_4438 # PIR H65243 H65243 # PROSITE PS00372 PTS_EIIA_TYPE_2_HIS # PROSITE PS51094 PTS_EIIA_TYPE_2 # Pfam PF00359 PTS_EIIA_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SGCA_ECOLI Putative phosphotransferase IIA component SgcA # RefSeq NP_418722 NC_000913.3 # RefSeq WP_000606406 NZ_LN832404.1 # SIMILARITY Contains 1 PTS EIIA type-2 domain. {ECO:0000255|PROSITE-ProRule PRU00417}. # SUBCELLULAR LOCATION SGCA_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF55804 SSF55804 # TCDB 4.A.5.1 the pts galactitol (gat) family # eggNOG ENOG4108XBJ Bacteria # eggNOG ENOG4111P54 LUCA BLAST swissprot:SGCA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SGCA_ECOLI BioCyc ECOL316407:JW4264-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4264-MONOMER BioCyc EcoCyc:SGCA-MONOMER http://biocyc.org/getid?id=EcoCyc:SGCA-MONOMER BioCyc MetaCyc:SGCA-MONOMER http://biocyc.org/getid?id=MetaCyc:SGCA-MONOMER COG COG1762 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1762 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 2.7.1.- http://enzyme.expasy.org/EC/2.7.1.- EchoBASE EB2442 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2442 EcoGene EG12554 http://www.ecogene.org/geneInfo.php?eg_id=EG12554 EnsemblBacteria AAC77258 http://www.ensemblgenomes.org/id/AAC77258 EnsemblBacteria AAC77258 http://www.ensemblgenomes.org/id/AAC77258 EnsemblBacteria BAE78293 http://www.ensemblgenomes.org/id/BAE78293 EnsemblBacteria BAE78293 http://www.ensemblgenomes.org/id/BAE78293 EnsemblBacteria BAE78293 http://www.ensemblgenomes.org/id/BAE78293 EnsemblBacteria b4302 http://www.ensemblgenomes.org/id/b4302 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.40.930.10 http://www.cathdb.info/version/latest/superfamily/3.40.930.10 GeneID 948831 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948831 HOGENOM HOG000227560 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000227560&db=HOGENOM6 IntAct P39363 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39363* IntEnz 2.7.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1 InterPro IPR002178 http://www.ebi.ac.uk/interpro/entry/IPR002178 InterPro IPR016152 http://www.ebi.ac.uk/interpro/entry/IPR016152 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW4264 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4264 KEGG_Gene eco:b4302 http://www.genome.jp/dbget-bin/www_bget?eco:b4302 KEGG_Orthology KO:K02773 http://www.genome.jp/dbget-bin/www_bget?KO:K02773 KEGG_Pathway ko00052 http://www.genome.jp/kegg-bin/show_pathway?ko00052 KEGG_Pathway ko02060 http://www.genome.jp/kegg-bin/show_pathway?ko02060 KEGG_Reaction rn:R05570 http://www.genome.jp/dbget-bin/www_bget?rn:R05570 OMA THIRTIQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=THIRTIQ PROSITE PS00372 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00372 PROSITE PS51094 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51094 PSORT swissprot:SGCA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SGCA_ECOLI PSORT-B swissprot:SGCA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SGCA_ECOLI PSORT2 swissprot:SGCA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SGCA_ECOLI Pfam PF00359 http://pfam.xfam.org/family/PF00359 Phobius swissprot:SGCA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SGCA_ECOLI PhylomeDB P39363 http://phylomedb.org/?seqid=P39363 ProteinModelPortal P39363 http://www.proteinmodelportal.org/query/uniprot/P39363 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418722 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418722 RefSeq WP_000606406 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000606406 SMR P39363 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39363 STRING 511145.b4302 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4302&targetmode=cogs STRING COG1762 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1762&targetmode=cogs SUPFAM SSF55804 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55804 TCDB 4.A.5.1 http://www.tcdb.org/search/result.php?tc=4.A.5.1 UniProtKB SGCA_ECOLI http://www.uniprot.org/uniprot/SGCA_ECOLI UniProtKB-AC P39363 http://www.uniprot.org/uniprot/P39363 charge swissprot:SGCA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SGCA_ECOLI eggNOG ENOG4108XBJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108XBJ eggNOG ENOG4111P54 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111P54 epestfind swissprot:SGCA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SGCA_ECOLI garnier swissprot:SGCA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SGCA_ECOLI helixturnhelix swissprot:SGCA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SGCA_ECOLI hmoment swissprot:SGCA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SGCA_ECOLI iep swissprot:SGCA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SGCA_ECOLI inforesidue swissprot:SGCA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SGCA_ECOLI octanol swissprot:SGCA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SGCA_ECOLI pepcoil swissprot:SGCA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SGCA_ECOLI pepdigest swissprot:SGCA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SGCA_ECOLI pepinfo swissprot:SGCA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SGCA_ECOLI pepnet swissprot:SGCA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SGCA_ECOLI pepstats swissprot:SGCA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SGCA_ECOLI pepwheel swissprot:SGCA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SGCA_ECOLI pepwindow swissprot:SGCA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SGCA_ECOLI sigcleave swissprot:SGCA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SGCA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262706 187 # CAUTION Was originally (PubMed:2973057) thought to be a protease. However, removal of residues 165-200 (a ClpP-protease-like motif) does not alter the lysogenization process, and in vitro studies show no evidence of a protease activity for the isolated HflKC complex. {ECO 0000305|PubMed:2973057}. # CDD cd03405 SPFH_HflC # EcoGene EG10435 hflC # FUNCTION HFLC_ECOLI HflC and HflK help govern the stability of phage lambda cII protein, and thereby control the lysogenization frequency of phage lambda. HflKC inhibits the SecY-degrading activity of FtsH, possibly helping quality control of integral membrane proteins. {ECO 0000269|PubMed 8947034}. # GO_component GO:0071575 integral component of external side of plasma membrane; IDA:EcoCyc. # GO_process GO:0009408 response to heat; IEP:EcoCyc. # GO_process GO:0052547 regulation of peptidase activity; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # IntAct P0ABC3 8 # InterPro IPR001107 Band_7 # InterPro IPR001972 Stomatin_fam # InterPro IPR010200 HflC # KEGG_Brite ko01000 Enzymes # MISCELLANEOUS HFLC_ECOLI Integration of this protein into the membrane depends on SecA, SecY and SecD but not on SecB or FtsY. HflC is unstable in the absence of HflK. # Organism HFLC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10264 PTHR10264; 2 # PATRIC 32123923 VBIEscCol129921_4306 # PIR C43653 C43653 # PIRSF PIRSF005651 HflC # Pfam PF01145 Band_7 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HFLC_ECOLI Modulator of FtsH protease HflC # RefSeq NP_418596 NC_000913.3 # RefSeq WP_001232412 NZ_LN832404.1 # SIMILARITY Belongs to the band 7/mec-2 family. HflC subfamily. {ECO 0000305}. # SMART SM00244 PHB # SUBCELLULAR LOCATION HFLC_ECOLI Cell inner membrane {ECO 0000269|PubMed 8947034}; Single-pass type II membrane protein {ECO 0000269|PubMed 8947034}. # SUBUNIT HFLC_ECOLI HflC and HflK interact to form a complex, originally called HflA, now called HflKC. HflKC interacts with FtsH; complex formation is stimulated by ATP, and with YccA. {ECO 0000269|PubMed 2973057, ECO 0000269|PubMed 8947034, ECO 0000269|PubMed 9636708}. # SUPFAM SSF117892 SSF117892; 2 # TIGRFAMs TIGR01932 hflC # eggNOG COG0330 LUCA # eggNOG ENOG4105EPW Bacteria BLAST swissprot:HFLC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HFLC_ECOLI BioCyc ECOL316407:JW4133-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4133-MONOMER BioCyc EcoCyc:EG10435-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10435-MONOMER BioCyc MetaCyc:EG10435-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10435-MONOMER COG COG0330 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0330 DIP DIP-35995N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35995N DOI 10.1006/jmbi.1998.1781 http://dx.doi.org/10.1006/jmbi.1998.1781 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.85.21.7882 http://dx.doi.org/10.1073/pnas.85.21.7882 DOI 10.1073/pnas.90.22.10866 http://dx.doi.org/10.1073/pnas.90.22.10866 DOI 10.1073/pnas.94.11.5544 http://dx.doi.org/10.1073/pnas.94.11.5544 DOI 10.1074/jbc.273.45.29770 http://dx.doi.org/10.1074/jbc.273.45.29770 DOI 10.1093/jb/mvp071 http://dx.doi.org/10.1093/jb/mvp071 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00005 http://www.ebi.ac.uk/ena/data/view/U00005 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB0430 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0430 EcoGene EG10435 http://www.ecogene.org/geneInfo.php?eg_id=EG10435 EnsemblBacteria AAC77132 http://www.ensemblgenomes.org/id/AAC77132 EnsemblBacteria AAC77132 http://www.ensemblgenomes.org/id/AAC77132 EnsemblBacteria BAE78176 http://www.ensemblgenomes.org/id/BAE78176 EnsemblBacteria BAE78176 http://www.ensemblgenomes.org/id/BAE78176 EnsemblBacteria BAE78176 http://www.ensemblgenomes.org/id/BAE78176 EnsemblBacteria b4175 http://www.ensemblgenomes.org/id/b4175 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0071575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071575 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GO_process GO:0052547 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052547 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 948697 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948697 HOGENOM HOG000260972 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260972&db=HOGENOM6 InParanoid P0ABC3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABC3 IntAct P0ABC3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABC3* InterPro IPR001107 http://www.ebi.ac.uk/interpro/entry/IPR001107 InterPro IPR001972 http://www.ebi.ac.uk/interpro/entry/IPR001972 InterPro IPR010200 http://www.ebi.ac.uk/interpro/entry/IPR010200 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4133 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4133 KEGG_Gene eco:b4175 http://www.genome.jp/dbget-bin/www_bget?eco:b4175 KEGG_Orthology KO:K04087 http://www.genome.jp/dbget-bin/www_bget?KO:K04087 MINT MINT-1256053 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1256053 OMA TRVDYVE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TRVDYVE PANTHER PTHR10264 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10264 PSORT swissprot:HFLC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HFLC_ECOLI PSORT-B swissprot:HFLC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HFLC_ECOLI PSORT2 swissprot:HFLC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HFLC_ECOLI Pfam PF01145 http://pfam.xfam.org/family/PF01145 Phobius swissprot:HFLC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HFLC_ECOLI PhylomeDB P0ABC3 http://phylomedb.org/?seqid=P0ABC3 ProteinModelPortal P0ABC3 http://www.proteinmodelportal.org/query/uniprot/P0ABC3 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19454621 http://www.ncbi.nlm.nih.gov/pubmed/19454621 PubMed 2973057 http://www.ncbi.nlm.nih.gov/pubmed/2973057 PubMed 3040675 http://www.ncbi.nlm.nih.gov/pubmed/3040675 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8248183 http://www.ncbi.nlm.nih.gov/pubmed/8248183 PubMed 8947034 http://www.ncbi.nlm.nih.gov/pubmed/8947034 PubMed 9159109 http://www.ncbi.nlm.nih.gov/pubmed/9159109 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9636708 http://www.ncbi.nlm.nih.gov/pubmed/9636708 PubMed 9792691 http://www.ncbi.nlm.nih.gov/pubmed/9792691 RefSeq NP_418596 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418596 RefSeq WP_001232412 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001232412 SMART SM00244 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00244 SMR P0ABC3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABC3 STRING 511145.b4175 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4175&targetmode=cogs STRING COG0330 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0330&targetmode=cogs SUPFAM SSF117892 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF117892 TIGRFAMs TIGR01932 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01932 UniProtKB HFLC_ECOLI http://www.uniprot.org/uniprot/HFLC_ECOLI UniProtKB-AC P0ABC3 http://www.uniprot.org/uniprot/P0ABC3 charge swissprot:HFLC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HFLC_ECOLI eggNOG COG0330 http://eggnogapi.embl.de/nog_data/html/tree/COG0330 eggNOG ENOG4105EPW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EPW epestfind swissprot:HFLC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HFLC_ECOLI garnier swissprot:HFLC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HFLC_ECOLI helixturnhelix swissprot:HFLC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HFLC_ECOLI hmoment swissprot:HFLC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HFLC_ECOLI iep swissprot:HFLC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HFLC_ECOLI inforesidue swissprot:HFLC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HFLC_ECOLI octanol swissprot:HFLC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HFLC_ECOLI pepcoil swissprot:HFLC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HFLC_ECOLI pepdigest swissprot:HFLC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HFLC_ECOLI pepinfo swissprot:HFLC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HFLC_ECOLI pepnet swissprot:HFLC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HFLC_ECOLI pepstats swissprot:HFLC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HFLC_ECOLI pepwheel swissprot:HFLC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HFLC_ECOLI pepwindow swissprot:HFLC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HFLC_ECOLI sigcleave swissprot:HFLC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HFLC_ECOLI ## Database ID URL or Descriptions # BioGrid 4261405 173 # CATALYTIC ACTIVITY MDLB_ECOLI ATP + H(2)O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out). # CAUTION Was originally proposed to be fused with MdlA. {ECO:0000305|PubMed 7904973}. # EcoGene EG14374 mdlB # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0008559 xenobiotic-transporting ATPase activity; IEA:UniProtKB-EC. # GO_function GO:0034040 lipid-transporting ATPase activity; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.300 -; 1. # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR011527 ABC1_TM_dom # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism MDLB_ECOLI Escherichia coli (strain K12) # PATRIC 32116051 VBIEscCol129921_0467 # PIR A64775 A64775 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # PROSITE PS50929 ABC_TM1F # Pfam PF00005 ABC_tran # Pfam PF00664 ABC_membrane # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MDLB_ECOLI Multidrug resistance-like ATP-binding protein MdlB # RefSeq NP_414983 NC_000913.3 # RefSeq WP_001256201 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40205.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAC36870.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ABC transporter superfamily. Drug exporter-2 (TC 3.A.1.117) family. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA # SUBCELLULAR LOCATION MDLB_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF52540 SSF52540 # SUPFAM SSF90123 SSF90123 # TCDB 3.A.1.106.13 the atp-binding cassette (abc) superfamily # eggNOG COG1132 LUCA # eggNOG ENOG4105BZ1 Bacteria BLAST swissprot:MDLB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MDLB_ECOLI BioCyc ECOL316407:JW5061-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5061-MONOMER BioCyc EcoCyc:MDLB-MONOMER http://biocyc.org/getid?id=EcoCyc:MDLB-MONOMER COG COG1132 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1132 COG COG2274 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2274 COG COG4988 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4988 DOI 10.1016/0378-1119(93)90470-N http://dx.doi.org/10.1016/0378-1119(93)90470-N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.3.44 http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.44 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L08627 http://www.ebi.ac.uk/ena/data/view/L08627 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 ENZYME 3.6.3.44 http://enzyme.expasy.org/EC/3.6.3.44 EchoBASE EB4117 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4117 EcoGene EG14374 http://www.ecogene.org/geneInfo.php?eg_id=EG14374 EnsemblBacteria AAC73552 http://www.ensemblgenomes.org/id/AAC73552 EnsemblBacteria AAC73552 http://www.ensemblgenomes.org/id/AAC73552 EnsemblBacteria BAE76229 http://www.ensemblgenomes.org/id/BAE76229 EnsemblBacteria BAE76229 http://www.ensemblgenomes.org/id/BAE76229 EnsemblBacteria BAE76229 http://www.ensemblgenomes.org/id/BAE76229 EnsemblBacteria b0449 http://www.ensemblgenomes.org/id/b0449 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008559 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008559 GO_function GO:0034040 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034040 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945088 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945088 InParanoid P0AAG5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAG5 IntEnz 3.6.3.44 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.44 InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR011527 http://www.ebi.ac.uk/interpro/entry/IPR011527 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5061 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5061 KEGG_Gene eco:b0449 http://www.genome.jp/dbget-bin/www_bget?eco:b0449 KEGG_Orthology KO:K06148 http://www.genome.jp/dbget-bin/www_bget?KO:K06148 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA IVMIIYQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IVMIIYQ PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PROSITE PS50929 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50929 PSORT swissprot:MDLB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MDLB_ECOLI PSORT-B swissprot:MDLB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MDLB_ECOLI PSORT2 swissprot:MDLB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MDLB_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Pfam PF00664 http://pfam.xfam.org/family/PF00664 Phobius swissprot:MDLB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MDLB_ECOLI PhylomeDB P0AAG5 http://phylomedb.org/?seqid=P0AAG5 ProteinModelPortal P0AAG5 http://www.proteinmodelportal.org/query/uniprot/P0AAG5 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7904973 http://www.ncbi.nlm.nih.gov/pubmed/7904973 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414983 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414983 RefSeq WP_001256201 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001256201 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P0AAG5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAG5 STRING 511145.b0449 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0449&targetmode=cogs STRING COG1132 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1132&targetmode=cogs STRING COG2274 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2274&targetmode=cogs STRING COG4988 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4988&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SUPFAM SSF90123 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90123 TCDB 3.A.1.106.13 http://www.tcdb.org/search/result.php?tc=3.A.1.106.13 UniProtKB MDLB_ECOLI http://www.uniprot.org/uniprot/MDLB_ECOLI UniProtKB-AC P0AAG5 http://www.uniprot.org/uniprot/P0AAG5 charge swissprot:MDLB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MDLB_ECOLI eggNOG COG1132 http://eggnogapi.embl.de/nog_data/html/tree/COG1132 eggNOG ENOG4105BZ1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZ1 epestfind swissprot:MDLB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MDLB_ECOLI garnier swissprot:MDLB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MDLB_ECOLI helixturnhelix swissprot:MDLB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MDLB_ECOLI hmoment swissprot:MDLB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MDLB_ECOLI iep swissprot:MDLB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MDLB_ECOLI inforesidue swissprot:MDLB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MDLB_ECOLI octanol swissprot:MDLB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MDLB_ECOLI pepcoil swissprot:MDLB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MDLB_ECOLI pepdigest swissprot:MDLB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MDLB_ECOLI pepinfo swissprot:MDLB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MDLB_ECOLI pepnet swissprot:MDLB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MDLB_ECOLI pepstats swissprot:MDLB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MDLB_ECOLI pepwheel swissprot:MDLB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MDLB_ECOLI pepwindow swissprot:MDLB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MDLB_ECOLI sigcleave swissprot:MDLB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MDLB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260224 9 # CATALYTIC ACTIVITY ATP + (S)-4,5-dihydroxypentane-2,3-dione = ADP + (S)-4-hydroxy-2,3-pentanedione 5-phosphate. {ECO:0000255|HAMAP- Rule MF_02053}. # CAUTION Was originally thought to originate from human and was called BRAG1 (brain-related apoptosis gene 1) with a proposed role in apoptosis (PubMed:8649811). The DNA sequence of the region sequenced is more than 99% identical to that of this E.coli gene. Furthermore the claim of an 'extensive similarity to the Bcl-2 family of genes' is not correct. {ECO 0000305|PubMed:8649811}. # EcoGene EG13804 lsrK # FUNCTION LSRK_ECOLI Catalyzes the phosphorylation of autoinducer-2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of (S)-4,5-dihydroxypentane-2,3- dione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position. Required for the regulation of the lsr operon and many other genes. {ECO 0000269|PubMed 15601708, ECO 0000269|PubMed 17557827, ECO 0000269|PubMed 20025244}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0016773 phosphotransferase activity, alcohol group as acceptor; IBA:GO_Central. # GO_function GO:0071518 autoinducer-2 kinase activity; IDA:EcoCyc. # GO_process GO:0005975 carbohydrate metabolic process; IEA:InterPro. # GO_process GO:0009372 quorum sensing; IMP:EcoCyc. # GO_process GO:0044010 single-species biofilm formation; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016301 kinase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0042592 homeostatic process # HAMAP MF_02053 LsrK # IntAct P77432 13 # InterPro IPR000577 Carb_kinase_FGGY # InterPro IPR018484 Carb_kinase_FGGY_N # InterPro IPR018485 Carb_kinase_FGGY_C # InterPro IPR033676 AI-2_kinase # KEGG_Brite ko01000 Enzymes # Organism LSRK_ECOLI Escherichia coli (strain K12) # PATRIC 32118318 VBIEscCol129921_1579 # PIR B64905 B64905 # PIRSF PIRSF000538 GlpK # Pfam PF00370 FGGY_N # Pfam PF02782 FGGY_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Autoinducer-2 kinase {ECO:0000255|HAMAP-Rule MF_02053} # RefSeq NP_416028 NC_000913.3 # RefSeq WP_000113108 NZ_LN832404.1 # SIMILARITY Belongs to the FGGY kinase family. {ECO:0000255|HAMAP- Rule MF_02053}. # SUBCELLULAR LOCATION LSRK_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_02053}. # eggNOG COG1070 LUCA # eggNOG ENOG4108EMV Bacteria BLAST swissprot:LSRK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LSRK_ECOLI BioCyc ECOL316407:JW1504-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1504-MONOMER BioCyc EcoCyc:G6798-MONOMER http://biocyc.org/getid?id=EcoCyc:G6798-MONOMER BioCyc MetaCyc:G6798-MONOMER http://biocyc.org/getid?id=MetaCyc:G6798-MONOMER COG COG1070 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1070 DIP DIP-11687N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11687N DOI 10.1021/cb9002738 http://dx.doi.org/10.1021/cb9002738 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00014-07 http://dx.doi.org/10.1128/JB.00014-07 DOI 10.1128/JB.187.1.238-248.2005 http://dx.doi.org/10.1128/JB.187.1.238-248.2005 EC_number EC:2.7.1.189 {ECO:0000255|HAMAP-Rule:MF_02053} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.189 {ECO:0000255|HAMAP-Rule:MF_02053} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL S82185 http://www.ebi.ac.uk/ena/data/view/S82185 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.189 {ECO:0000255|HAMAP-Rule:MF_02053} http://enzyme.expasy.org/EC/2.7.1.189 {ECO:0000255|HAMAP-Rule:MF_02053} EchoBASE EB3565 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3565 EcoGene EG13804 http://www.ecogene.org/geneInfo.php?eg_id=EG13804 EnsemblBacteria AAC74584 http://www.ensemblgenomes.org/id/AAC74584 EnsemblBacteria AAC74584 http://www.ensemblgenomes.org/id/AAC74584 EnsemblBacteria BAA15191 http://www.ensemblgenomes.org/id/BAA15191 EnsemblBacteria BAA15191 http://www.ensemblgenomes.org/id/BAA15191 EnsemblBacteria BAA15191 http://www.ensemblgenomes.org/id/BAA15191 EnsemblBacteria b1511 http://www.ensemblgenomes.org/id/b1511 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0016773 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016773 GO_function GO:0071518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071518 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GO_process GO:0009372 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009372 GO_process GO:0044010 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044010 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GeneID 946069 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946069 HAMAP MF_02053 http://hamap.expasy.org/unirule/MF_02053 HOGENOM HOG000092677 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000092677&db=HOGENOM6 InParanoid P77432 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77432 IntAct P77432 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77432* IntEnz 2.7.1.189 {ECO:0000255|HAMAP-Rule:MF_02053} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.189 {ECO:0000255|HAMAP-Rule:MF_02053} InterPro IPR000577 http://www.ebi.ac.uk/interpro/entry/IPR000577 InterPro IPR018484 http://www.ebi.ac.uk/interpro/entry/IPR018484 InterPro IPR018485 http://www.ebi.ac.uk/interpro/entry/IPR018485 InterPro IPR033676 http://www.ebi.ac.uk/interpro/entry/IPR033676 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1504 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1504 KEGG_Gene eco:b1511 http://www.genome.jp/dbget-bin/www_bget?eco:b1511 KEGG_Orthology KO:K11216 http://www.genome.jp/dbget-bin/www_bget?KO:K11216 MINT MINT-1251018 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1251018 OMA FSDAMHF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FSDAMHF PSORT swissprot:LSRK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LSRK_ECOLI PSORT-B swissprot:LSRK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LSRK_ECOLI PSORT2 swissprot:LSRK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LSRK_ECOLI Pfam PF00370 http://pfam.xfam.org/family/PF00370 Pfam PF02782 http://pfam.xfam.org/family/PF02782 Phobius swissprot:LSRK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LSRK_ECOLI PhylomeDB P77432 http://phylomedb.org/?seqid=P77432 ProteinModelPortal P77432 http://www.proteinmodelportal.org/query/uniprot/P77432 PubMed 15601708 http://www.ncbi.nlm.nih.gov/pubmed/15601708 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17557827 http://www.ncbi.nlm.nih.gov/pubmed/17557827 PubMed 20025244 http://www.ncbi.nlm.nih.gov/pubmed/20025244 PubMed 8649811 http://www.ncbi.nlm.nih.gov/pubmed/8649811 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416028 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416028 RefSeq WP_000113108 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000113108 SMR P77432 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77432 STRING 511145.b1511 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1511&targetmode=cogs STRING COG1070 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1070&targetmode=cogs UniProtKB LSRK_ECOLI http://www.uniprot.org/uniprot/LSRK_ECOLI UniProtKB-AC P77432 http://www.uniprot.org/uniprot/P77432 charge swissprot:LSRK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LSRK_ECOLI eggNOG COG1070 http://eggnogapi.embl.de/nog_data/html/tree/COG1070 eggNOG ENOG4108EMV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108EMV epestfind swissprot:LSRK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LSRK_ECOLI garnier swissprot:LSRK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LSRK_ECOLI helixturnhelix swissprot:LSRK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LSRK_ECOLI hmoment swissprot:LSRK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LSRK_ECOLI iep swissprot:LSRK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LSRK_ECOLI inforesidue swissprot:LSRK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LSRK_ECOLI octanol swissprot:LSRK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LSRK_ECOLI pepcoil swissprot:LSRK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LSRK_ECOLI pepdigest swissprot:LSRK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LSRK_ECOLI pepinfo swissprot:LSRK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LSRK_ECOLI pepnet swissprot:LSRK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LSRK_ECOLI pepstats swissprot:LSRK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LSRK_ECOLI pepwheel swissprot:LSRK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LSRK_ECOLI pepwindow swissprot:LSRK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LSRK_ECOLI sigcleave swissprot:LSRK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LSRK_ECOLI ## Database ID URL or Descriptions # BioGrid 4261909 10 # COFACTOR Name=FMN; Xref=ChEBI:CHEBI 58210; # EcoGene EG10318 fldA # FUNCTION FLAV_ECOLI Low-potential electron donor to a number of redox enzymes (Potential). Involved in the reactivation of inactive cob(II)alamin in methionine synthase. {ECO 0000269|PubMed 9730838, ECO 0000305}. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0009055 electron carrier activity; IEA:InterPro. # GO_function GO:0010181 FMN binding; IEA:InterPro. # GO_process GO:0055114 oxidation-reduction process; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.360 -; 1. # INTERACTION FLAV_ECOLI P33596 recX; NbExp=3; IntAct=EBI-550021, EBI-1129990; P76066 ydaW; NbExp=2; IntAct=EBI-550021, EBI-9142914; # IntAct P61949 29 # InterPro IPR001226 Flavodoxin_CS # InterPro IPR008254 Flavodoxin/NO_synth # InterPro IPR010086 Flavodoxin_lc # InterPro IPR029039 Flavoprotein-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko00910 Nitrogen metabolism # Organism FLAV_ECOLI Escherichia coli (strain K12) # PATRIC 32116561 VBIEscCol129921_0713 # PDB 1AG9 X-ray; 1.80 A; A/B=2-176 # PDB 1AHN X-ray; 2.60 A; A=2-176 # PDB 2MOK NMR; -; A=1-176 # PIR A37319 A37319 # PIRSF PIRSF038996 FldA # PROSITE PS00201 FLAVODOXIN # PROSITE PS50902 FLAVODOXIN_LIKE # Pfam PF00258 Flavodoxin_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FLAV_ECOLI Flavodoxin-1 # RefSeq NP_415210 NC_000913.3 # RefSeq WP_001018618 NZ_LN832404.1 # SIMILARITY Belongs to the flavodoxin family. {ECO 0000305}. # SIMILARITY Contains 1 flavodoxin-like domain. {ECO:0000255|PROSITE-ProRule PRU00088}. # SUPFAM SSF52218 SSF52218 # TIGRFAMs TIGR01752 flav_long # eggNOG COG0716 LUCA # eggNOG ENOG4105MHQ Bacteria BLAST swissprot:FLAV_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLAV_ECOLI BioCyc ECOL316407:JW0671-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0671-MONOMER BioCyc EcoCyc:FLAVODOXIN1-MONOMER http://biocyc.org/getid?id=EcoCyc:FLAVODOXIN1-MONOMER COG COG0716 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0716 DIP DIP-48242N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48242N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/pro.5560061205 http://dx.doi.org/10.1002/pro.5560061205 DOI 10.1021/bi9808565 http://dx.doi.org/10.1021/bi9808565 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1432-1033.1997.00384.x http://dx.doi.org/10.1111/j.1432-1033.1997.00384.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M59426 http://www.ebi.ac.uk/ena/data/view/M59426 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0314 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0314 EcoGene EG10318 http://www.ecogene.org/geneInfo.php?eg_id=EG10318 EnsemblBacteria AAC73778 http://www.ensemblgenomes.org/id/AAC73778 EnsemblBacteria AAC73778 http://www.ensemblgenomes.org/id/AAC73778 EnsemblBacteria BAA35333 http://www.ensemblgenomes.org/id/BAA35333 EnsemblBacteria BAA35333 http://www.ensemblgenomes.org/id/BAA35333 EnsemblBacteria BAA35333 http://www.ensemblgenomes.org/id/BAA35333 EnsemblBacteria b0684 http://www.ensemblgenomes.org/id/b0684 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0010181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010181 GO_process GO:0055114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.360 http://www.cathdb.info/version/latest/superfamily/3.40.50.360 GeneID 945293 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945293 HOGENOM HOG000030543 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000030543&db=HOGENOM6 InParanoid P61949 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P61949 IntAct P61949 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P61949* InterPro IPR001226 http://www.ebi.ac.uk/interpro/entry/IPR001226 InterPro IPR008254 http://www.ebi.ac.uk/interpro/entry/IPR008254 InterPro IPR010086 http://www.ebi.ac.uk/interpro/entry/IPR010086 InterPro IPR029039 http://www.ebi.ac.uk/interpro/entry/IPR029039 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW0671 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0671 KEGG_Gene eco:b0684 http://www.genome.jp/dbget-bin/www_bget?eco:b0684 KEGG_Orthology KO:K03839 http://www.genome.jp/dbget-bin/www_bget?KO:K03839 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Reaction rn:R05186 http://www.genome.jp/dbget-bin/www_bget?rn:R05186 MINT MINT-1239730 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1239730 OMA ASKGMAD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ASKGMAD PDB 1AG9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1AG9 PDB 1AHN http://www.ebi.ac.uk/pdbe-srv/view/entry/1AHN PDB 2MOK http://www.ebi.ac.uk/pdbe-srv/view/entry/2MOK PDBsum 1AG9 http://www.ebi.ac.uk/pdbsum/1AG9 PDBsum 1AHN http://www.ebi.ac.uk/pdbsum/1AHN PDBsum 2MOK http://www.ebi.ac.uk/pdbsum/2MOK PROSITE PS00201 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00201 PROSITE PS50902 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50902 PSORT swissprot:FLAV_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLAV_ECOLI PSORT-B swissprot:FLAV_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLAV_ECOLI PSORT2 swissprot:FLAV_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLAV_ECOLI Pfam PF00258 http://pfam.xfam.org/family/PF00258 Phobius swissprot:FLAV_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLAV_ECOLI PhylomeDB P61949 http://phylomedb.org/?seqid=P61949 ProteinModelPortal P61949 http://www.proteinmodelportal.org/query/uniprot/P61949 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1999390 http://www.ncbi.nlm.nih.gov/pubmed/1999390 PubMed 7961651 http://www.ncbi.nlm.nih.gov/pubmed/7961651 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9119004 http://www.ncbi.nlm.nih.gov/pubmed/9119004 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9416602 http://www.ncbi.nlm.nih.gov/pubmed/9416602 PubMed 9730838 http://www.ncbi.nlm.nih.gov/pubmed/9730838 RefSeq NP_415210 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415210 RefSeq WP_001018618 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001018618 SMR P61949 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P61949 STRING 511145.b0684 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0684&targetmode=cogs STRING COG0716 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0716&targetmode=cogs SUPFAM SSF52218 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52218 TIGRFAMs TIGR01752 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01752 UniProtKB FLAV_ECOLI http://www.uniprot.org/uniprot/FLAV_ECOLI UniProtKB-AC P61949 http://www.uniprot.org/uniprot/P61949 charge swissprot:FLAV_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLAV_ECOLI eggNOG COG0716 http://eggnogapi.embl.de/nog_data/html/tree/COG0716 eggNOG ENOG4105MHQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105MHQ epestfind swissprot:FLAV_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLAV_ECOLI garnier swissprot:FLAV_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLAV_ECOLI helixturnhelix swissprot:FLAV_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLAV_ECOLI hmoment swissprot:FLAV_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLAV_ECOLI iep swissprot:FLAV_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLAV_ECOLI inforesidue swissprot:FLAV_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLAV_ECOLI octanol swissprot:FLAV_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLAV_ECOLI pepcoil swissprot:FLAV_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLAV_ECOLI pepdigest swissprot:FLAV_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLAV_ECOLI pepinfo swissprot:FLAV_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLAV_ECOLI pepnet swissprot:FLAV_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLAV_ECOLI pepstats swissprot:FLAV_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLAV_ECOLI pepwheel swissprot:FLAV_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLAV_ECOLI pepwindow swissprot:FLAV_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLAV_ECOLI sigcleave swissprot:FLAV_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLAV_ECOLI ## Database ID URL or Descriptions # AltName MEPM_ECOLI Murein hydrolase MepM # AltName MEPM_ECOLI ORFU # BioGrid 4260352 359 # CDD cd00118 LysM # COFACTOR MEPM_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 23062283}; Name=Ca(2+); Xref=ChEBI CHEBI 29108; Evidence={ECO 0000269|PubMed 23062283}; Note=Zinc, although calcium also allows some activity. {ECO 0000269|PubMed 23062283}; # DISRUPTION PHENOTYPE MEPM_ECOLI Cells are shorter in a single mutant, while triple envC-nlpD-mepM disruptions have defects in septation and cell separation and form long filaments (15-fold longer) and further yet by the quadruple disruption mutant (envC-nlpD-mepM- ygeR, over 21-fold longer). Quadruple mutants are less sensitive to ampicillin lysis (PubMed 19525345). A triple mepS-mepH-mepM mutant is inviable, whereas a double mepS-mepM will grow on a nutrient-poor medium but not on a rich medium, suggesting the 3 endopeptidases are functionally redundant in vivo. Depletion experiments of the double or triple mutants lead to cell lysis, as well as significantly decreased incorporation of mDAP into peptidogylcan sacculi and increased amounts of the enzyme's substrate (Tetra-Tetra-anhydro muropeptide) (PubMed 23062283). {ECO 0000269|PubMed 19525345, ECO 0000269|PubMed 23062283}. # EcoGene EG10013 mepM # FUNCTION MEPM_ECOLI A murein DD-endopeptidase with specificity for D-Ala- meso-diaminopimelic acid (mDAP) cross-links. Its role is probably to cleave D-Ala-mDAP cross-links to allow insertion of new glycans and thus cell wall expansion. Functionally redundant with MepM and MepH. Partially suppresses an mepS disruption mutant. {ECO 0000269|PubMed 23062283}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0004175 endopeptidase activity; IDA:CACAO. # GO_function GO:0004222 metalloendopeptidase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0000270 peptidoglycan metabolic process; IDA:EcoCyc. # GO_process GO:0000920 cell separation after cytokinesis; IGI:EcoliWiki. # GO_process GO:0001896 autolysis; IGI:EcoliWiki. # GO_process GO:0045227 capsule polysaccharide biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0008219 cell death # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 3.10.350.10 -; 1. # InterPro IPR011055 Dup_hybrid_motif # InterPro IPR013731 OapA_N # InterPro IPR016047 Peptidase_M23 # InterPro IPR018392 LysM_dom # KEGG_Brite ko01000 Enzymes # Organism MEPM_ECOLI Escherichia coli (strain K12) # PATHWAY MEPM_ECOLI Cell wall biogenesis; cell wall polysaccharide biosynthesis. # PATRIC 32119035 VBIEscCol129921_1935 # PROSITE PS51782 LYSM # Pfam PF01476 LysM # Pfam PF01551 Peptidase_M23 # Pfam PF08525 OapA_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MEPM_ECOLI Murein DD-endopeptidase MepM # RefSeq NP_416370 NC_000913.3 # RefSeq WP_001184045 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA81029.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the peptidase M23B family. {ECO 0000305}. # SIMILARITY Contains 1 LysM domain. {ECO:0000255|PROSITE- ProRule PRU01118}. # SMART SM00257 LysM # SUBCELLULAR LOCATION MEPM_ECOLI Cell inner membrane {ECO 0000305}; Single- pass membrane protein {ECO 0000305}. Note=Uniform peripheral location, with partial enrichment at cell poles. # SUPFAM SSF51261 SSF51261 # SUPFAM SSF54106 SSF54106 # eggNOG COG0739 LUCA # eggNOG ENOG4105DR5 Bacteria BLAST swissprot:MEPM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MEPM_ECOLI BioCyc ECOL316407:JW5304-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5304-MONOMER BioCyc EcoCyc:EG10013-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10013-MONOMER BioCyc MetaCyc:EG10013-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10013-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1111/mmi.12058 http://dx.doi.org/10.1111/mmi.12058 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00505-09 http://dx.doi.org/10.1128/JB.00505-09 EC_number EC:3.4.24.- http://www.genome.jp/dbget-bin/www_bget?EC:3.4.24.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M77039 http://www.ebi.ac.uk/ena/data/view/M77039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U38702 http://www.ebi.ac.uk/ena/data/view/U38702 ENZYME 3.4.24.- http://enzyme.expasy.org/EC/3.4.24.- EchoBASE EB0013 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0013 EcoGene EG10013 http://www.ecogene.org/geneInfo.php?eg_id=EG10013 EnsemblBacteria AAC74926 http://www.ensemblgenomes.org/id/AAC74926 EnsemblBacteria AAC74926 http://www.ensemblgenomes.org/id/AAC74926 EnsemblBacteria BAA15664 http://www.ensemblgenomes.org/id/BAA15664 EnsemblBacteria BAA15664 http://www.ensemblgenomes.org/id/BAA15664 EnsemblBacteria BAA15664 http://www.ensemblgenomes.org/id/BAA15664 EnsemblBacteria b1856 http://www.ensemblgenomes.org/id/b1856 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0004175 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004175 GO_function GO:0004222 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004222 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0000270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000270 GO_process GO:0000920 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000920 GO_process GO:0001896 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001896 GO_process GO:0045227 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045227 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0008219 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008219 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 3.10.350.10 http://www.cathdb.info/version/latest/superfamily/3.10.350.10 GeneID 946376 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946376 HOGENOM HOG000281149 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000281149&db=HOGENOM6 InParanoid P0AFS9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFS9 IntEnz 3.4.24 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4.24 InterPro IPR011055 http://www.ebi.ac.uk/interpro/entry/IPR011055 InterPro IPR013731 http://www.ebi.ac.uk/interpro/entry/IPR013731 InterPro IPR016047 http://www.ebi.ac.uk/interpro/entry/IPR016047 InterPro IPR018392 http://www.ebi.ac.uk/interpro/entry/IPR018392 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5304 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5304 KEGG_Gene eco:b1856 http://www.genome.jp/dbget-bin/www_bget?eco:b1856 KEGG_Orthology KO:K01417 http://www.genome.jp/dbget-bin/www_bget?KO:K01417 OMA EYQTVYM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EYQTVYM PROSITE PS51782 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51782 PSORT swissprot:MEPM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MEPM_ECOLI PSORT-B swissprot:MEPM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MEPM_ECOLI PSORT2 swissprot:MEPM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MEPM_ECOLI Pfam PF01476 http://pfam.xfam.org/family/PF01476 Pfam PF01551 http://pfam.xfam.org/family/PF01551 Pfam PF08525 http://pfam.xfam.org/family/PF08525 Phobius swissprot:MEPM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MEPM_ECOLI PhylomeDB P0AFS9 http://phylomedb.org/?seqid=P0AFS9 ProteinModelPortal P0AFS9 http://www.proteinmodelportal.org/query/uniprot/P0AFS9 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1732206 http://www.ncbi.nlm.nih.gov/pubmed/1732206 PubMed 19525345 http://www.ncbi.nlm.nih.gov/pubmed/19525345 PubMed 23062283 http://www.ncbi.nlm.nih.gov/pubmed/23062283 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416370 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416370 RefSeq WP_001184045 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001184045 SMART SM00257 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00257 SMR P0AFS9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFS9 STRING 511145.b1856 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1856&targetmode=cogs SUPFAM SSF51261 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51261 SUPFAM SSF54106 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54106 UniProtKB MEPM_ECOLI http://www.uniprot.org/uniprot/MEPM_ECOLI UniProtKB-AC P0AFS9 http://www.uniprot.org/uniprot/P0AFS9 charge swissprot:MEPM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MEPM_ECOLI eggNOG COG0739 http://eggnogapi.embl.de/nog_data/html/tree/COG0739 eggNOG ENOG4105DR5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DR5 epestfind swissprot:MEPM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MEPM_ECOLI garnier swissprot:MEPM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MEPM_ECOLI helixturnhelix swissprot:MEPM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MEPM_ECOLI hmoment swissprot:MEPM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MEPM_ECOLI iep swissprot:MEPM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MEPM_ECOLI inforesidue swissprot:MEPM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MEPM_ECOLI octanol swissprot:MEPM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MEPM_ECOLI pepcoil swissprot:MEPM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MEPM_ECOLI pepdigest swissprot:MEPM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MEPM_ECOLI pepinfo swissprot:MEPM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MEPM_ECOLI pepnet swissprot:MEPM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MEPM_ECOLI pepstats swissprot:MEPM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MEPM_ECOLI pepwheel swissprot:MEPM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MEPM_ECOLI pepwindow swissprot:MEPM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MEPM_ECOLI sigcleave swissprot:MEPM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MEPM_ECOLI ## Database ID URL or Descriptions # BioGrid 4263462 96 # EcoGene EG13331 yafS # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0008757 S-adenosylmethionine-dependent methyltransferase activity; IBA:GO_Central. # GO_process GO:0032259 methylation; IBA:GO_Central. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.150 -; 1. # IntAct P75672 2 # InterPro IPR013216 Methyltransf_11 # InterPro IPR029063 SAM-dependent_MTases # Organism YAFS_ECOLI Escherichia coli (strain K12) # PATRIC 32115539 VBIEscCol129921_0215 # PIR G64745 G64745 # Pfam PF08241 Methyltransf_11 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAFS_ECOLI Uncharacterized protein YafS # RefSeq NP_414749 NC_000913.3 # RefSeq WP_001326702 NZ_LN832404.1 # SUPFAM SSF53335 SSF53335 # eggNOG COG0500 LUCA # eggNOG ENOG4105D1A Bacteria BLAST swissprot:YAFS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAFS_ECOLI BioCyc ECOL316407:JW0203-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0203-MONOMER BioCyc EcoCyc:G6100-MONOMER http://biocyc.org/getid?id=EcoCyc:G6100-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EchoBASE EB3115 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3115 EcoGene EG13331 http://www.ecogene.org/geneInfo.php?eg_id=EG13331 EnsemblBacteria AAC73318 http://www.ensemblgenomes.org/id/AAC73318 EnsemblBacteria AAC73318 http://www.ensemblgenomes.org/id/AAC73318 EnsemblBacteria BAA77884 http://www.ensemblgenomes.org/id/BAA77884 EnsemblBacteria BAA77884 http://www.ensemblgenomes.org/id/BAA77884 EnsemblBacteria BAA77884 http://www.ensemblgenomes.org/id/BAA77884 EnsemblBacteria b0213 http://www.ensemblgenomes.org/id/b0213 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0008757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008757 GO_process GO:0032259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032259 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 GeneID 944903 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944903 HOGENOM HOG000258628 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000258628&db=HOGENOM6 InParanoid P75672 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75672 IntAct P75672 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75672* InterPro IPR013216 http://www.ebi.ac.uk/interpro/entry/IPR013216 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 KEGG_Gene ecj:JW0203 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0203 KEGG_Gene eco:b0213 http://www.genome.jp/dbget-bin/www_bget?eco:b0213 OMA PYCSRMF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PYCSRMF PSORT swissprot:YAFS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAFS_ECOLI PSORT-B swissprot:YAFS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAFS_ECOLI PSORT2 swissprot:YAFS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAFS_ECOLI Pfam PF08241 http://pfam.xfam.org/family/PF08241 Phobius swissprot:YAFS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAFS_ECOLI ProteinModelPortal P75672 http://www.proteinmodelportal.org/query/uniprot/P75672 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414749 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414749 RefSeq WP_001326702 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001326702 SMR P75672 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75672 STRING 511145.b0213 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0213&targetmode=cogs SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 UniProtKB YAFS_ECOLI http://www.uniprot.org/uniprot/YAFS_ECOLI UniProtKB-AC P75672 http://www.uniprot.org/uniprot/P75672 charge swissprot:YAFS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAFS_ECOLI eggNOG COG0500 http://eggnogapi.embl.de/nog_data/html/tree/COG0500 eggNOG ENOG4105D1A http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D1A epestfind swissprot:YAFS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAFS_ECOLI garnier swissprot:YAFS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAFS_ECOLI helixturnhelix swissprot:YAFS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAFS_ECOLI hmoment swissprot:YAFS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAFS_ECOLI iep swissprot:YAFS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAFS_ECOLI inforesidue swissprot:YAFS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAFS_ECOLI octanol swissprot:YAFS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAFS_ECOLI pepcoil swissprot:YAFS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAFS_ECOLI pepdigest swissprot:YAFS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAFS_ECOLI pepinfo swissprot:YAFS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAFS_ECOLI pepnet swissprot:YAFS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAFS_ECOLI pepstats swissprot:YAFS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAFS_ECOLI pepwheel swissprot:YAFS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAFS_ECOLI pepwindow swissprot:YAFS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAFS_ECOLI sigcleave swissprot:YAFS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAFS_ECOLI ## Database ID URL or Descriptions # AltName Spermidine/spermine N(1)-acetyltransferase {ECO:0000303|PubMed 7052085} # BIOPHYSICOCHEMICAL PROPERTIES ATDA_ECOLI Kinetic parameters KM=2 uM for AcCoA (in the presence of 3 mM spermidine at pH 7.5 and 37 degrees Celsius) {ECO 0000269|PubMed 8077207}; KM=220 uM for spermine (in the presence of 10 uM AcCoA at pH 7.5 and 37 degrees Celsius) {ECO 0000269|PubMed 8077207}; KM=1290 uM for spermidine (in the presence of 10 uM AcCoA at pH 7.5 and 37 degrees Celsius) {ECO 0000269|PubMed 8077207}; Temperature dependence The level of spermidine acetyltransferase activity increases at low temperature to prevent spermidine toxicity. {ECO 0000269|PubMed 10986239}; # BioGrid 4260234 7 # CATALYTIC ACTIVITY ATDA_ECOLI Acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine. {ECO 0000269|PubMed 7052085, ECO 0000269|PubMed 8077207}. # DISRUPTION PHENOTYPE ATDA_ECOLI Cells lacking this gene accumulate spermidine at late stationary phase and show a reduced cell viability due to a decrease in protein biosynthesis (PubMed 7642535). At 37 degrees Celsius, growth of mutant is normal in the presence of 0.5 or 1 mM spermidine. However, following a shift to 7 degrees Celsius, the addition of 0.5 or 1 mM spermidine results in inhibition of cellular growth or cell lysis, respectively. Furthermore, at 7 degrees Celsius, spermidine accumulation resulted in a decrease in total protein synthesis accompanied by an increase in the synthesis of the major cold shock proteins CspA, CspB, and CspG (PubMed 10986239). {ECO 0000269|PubMed 10986239, ECO 0000269|PubMed 7642535}. # ENZYME REGULATION ATDA_ECOLI Heat shock, alkaline shift, ethanol treatment and poor nutrient availability produce increased concentrations of monoacetylated spermidine (PubMed 2061318). Inhibited by alkaline phosphatase, N(1),N(8)-bis(ethyl)spermidine (BESPD) and N(1),N(12)-bis(ethyl)spermidine (BESPM) (PubMed 8077207, PubMed 6297970). {ECO 0000269|PubMed 2061318, ECO 0000269|PubMed 6297970, ECO 0000269|PubMed 8077207}. # EcoGene EG12447 speG # FUNCTION ATDA_ECOLI Involved in the protection against polyamine toxicity by regulating their concentration (PubMed 7642535, PubMed 10986239). Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to the primary amino groups of spermidine to yield N(1)- and N(8)-acetylspermidine (PubMed 8077207, PubMed 7052085, PubMed 6297970). It can also use polyamines such as spermine, but not putrescine (PubMed 7052085). {ECO 0000269|PubMed 10986239, ECO 0000269|PubMed 6297970, ECO 0000269|PubMed 7052085, ECO 0000269|PubMed 7642535, ECO 0000269|PubMed 8077207}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0000287 magnesium ion binding; IDA:UniProtKB. # GO_function GO:0004145 diamine N-acetyltransferase activity; IDA:UniProtKB. # GO_process GO:0006474 N-terminal protein amino acid acetylation; IBA:GO_Central. # GO_process GO:0006598 polyamine catabolic process; IMP:UniProtKB. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.630.30 -; 1. # INDUCTION Constitutively expressed throughout log and plateau phases of growth. {ECO:0000269|PubMed 2061318}. # IntAct P0A951 11 # InterPro IPR000182 GNAT_dom # InterPro IPR016181 Acyl_CoA_acyltransferase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00330 Arginine and proline metabolism # MISCELLANEOUS Acetylation neutralizes the charge of the polyamine, which is then typically excreted from the cell. {ECO:0000269|PubMed 8077207}. # Organism ATDA_ECOLI Escherichia coli (strain K12) # PATRIC 32118470 VBIEscCol129921_1655 # PDB 4R9M X-ray; 2.90 A; A/B/C=1-186 # PIR A55345 A55345 # PROSITE PS51186 GNAT # Pfam PF13302 Acetyltransf_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Spermidine N(1)-acetyltransferase {ECO:0000303|PubMed 7052085} # RefSeq NP_416101 NC_000913.3 # RefSeq WP_001138581 NZ_LN832404.1 # SIMILARITY Belongs to the acetyltransferase family. {ECO 0000305}. # SIMILARITY Contains 1 N-acetyltransferase domain. {ECO:0000255|PROSITE-ProRule PRU00532}. # SUBCELLULAR LOCATION ATDA_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT ATDA_ECOLI Homotetramer. {ECO 0000269|PubMed 23908034, ECO 0000269|PubMed 8077207}. # SUPFAM SSF55729 SSF55729 # eggNOG COG1670 LUCA # eggNOG ENOG4108MK9 Bacteria BLAST swissprot:ATDA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ATDA_ECOLI BioCyc ECOL316407:JW1576-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1576-MONOMER BioCyc EcoCyc:SPERMACTRAN-MONOMER http://biocyc.org/getid?id=EcoCyc:SPERMACTRAN-MONOMER BioCyc MetaCyc:SPERMACTRAN-MONOMER http://biocyc.org/getid?id=MetaCyc:SPERMACTRAN-MONOMER COG COG1670 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1670 DOI 10.1016/0006-291X(82)91233-5 http://dx.doi.org/10.1016/0006-291X(82)91233-5 DOI 10.1016/0014-5793(82)81336-7 http://dx.doi.org/10.1016/0014-5793(82)81336-7 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.270.32.18831 http://dx.doi.org/10.1074/jbc.270.32.18831 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1107/S1744309113017132 http://dx.doi.org/10.1107/S1744309113017132 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.19.5373-5380.2000 http://dx.doi.org/10.1128/JB.182.19.5373-5380.2000 EC_number EC:2.3.1.57 {ECO:0000269|PubMed:7052085, ECO:0000269|PubMed:8077207} http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.57 {ECO:0000269|PubMed:7052085, ECO:0000269|PubMed:8077207} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D25276 http://www.ebi.ac.uk/ena/data/view/D25276 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.3.1.57 {ECO:0000269|PubMed:7052085, ECO:0000269|PubMed:8077207} http://enzyme.expasy.org/EC/2.3.1.57 {ECO:0000269|PubMed:7052085, ECO:0000269|PubMed:8077207} EchoBASE EB2341 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2341 EcoGene EG12447 http://www.ecogene.org/geneInfo.php?eg_id=EG12447 EnsemblBacteria AAC74656 http://www.ensemblgenomes.org/id/AAC74656 EnsemblBacteria AAC74656 http://www.ensemblgenomes.org/id/AAC74656 EnsemblBacteria BAA15286 http://www.ensemblgenomes.org/id/BAA15286 EnsemblBacteria BAA15286 http://www.ensemblgenomes.org/id/BAA15286 EnsemblBacteria BAA15286 http://www.ensemblgenomes.org/id/BAA15286 EnsemblBacteria b1584 http://www.ensemblgenomes.org/id/b1584 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0004145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004145 GO_process GO:0006474 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006474 GO_process GO:0006598 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006598 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.630.30 http://www.cathdb.info/version/latest/superfamily/3.40.630.30 GeneID 946117 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946117 HOGENOM HOG000078522 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000078522&db=HOGENOM6 InParanoid P0A951 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A951 IntAct P0A951 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A951* IntEnz 2.3.1.57 {ECO:0000269|PubMed:7052085, ECO:0000269|PubMed:8077207} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.57 {ECO:0000269|PubMed:7052085, ECO:0000269|PubMed:8077207} InterPro IPR000182 http://www.ebi.ac.uk/interpro/entry/IPR000182 InterPro IPR016181 http://www.ebi.ac.uk/interpro/entry/IPR016181 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1576 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1576 KEGG_Gene eco:b1584 http://www.genome.jp/dbget-bin/www_bget?eco:b1584 KEGG_Orthology KO:K00657 http://www.genome.jp/dbget-bin/www_bget?KO:K00657 KEGG_Pathway ko00330 http://www.genome.jp/kegg-bin/show_pathway?ko00330 KEGG_Reaction rn:R01154 http://www.genome.jp/dbget-bin/www_bget?rn:R01154 OMA IISPEHQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IISPEHQ PDB 4R9M http://www.ebi.ac.uk/pdbe-srv/view/entry/4R9M PDBsum 4R9M http://www.ebi.ac.uk/pdbsum/4R9M PROSITE PS51186 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51186 PSORT swissprot:ATDA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ATDA_ECOLI PSORT-B swissprot:ATDA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ATDA_ECOLI PSORT2 swissprot:ATDA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ATDA_ECOLI Pfam PF13302 http://pfam.xfam.org/family/PF13302 Phobius swissprot:ATDA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ATDA_ECOLI PhylomeDB P0A951 http://phylomedb.org/?seqid=P0A951 ProteinModelPortal P0A951 http://www.proteinmodelportal.org/query/uniprot/P0A951 PubMed 10986239 http://www.ncbi.nlm.nih.gov/pubmed/10986239 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2061318 http://www.ncbi.nlm.nih.gov/pubmed/2061318 PubMed 23908034 http://www.ncbi.nlm.nih.gov/pubmed/23908034 PubMed 6297970 http://www.ncbi.nlm.nih.gov/pubmed/6297970 PubMed 7052085 http://www.ncbi.nlm.nih.gov/pubmed/7052085 PubMed 7642535 http://www.ncbi.nlm.nih.gov/pubmed/7642535 PubMed 8077207 http://www.ncbi.nlm.nih.gov/pubmed/8077207 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416101 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416101 RefSeq WP_001138581 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001138581 SMR P0A951 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A951 STRING 511145.b1584 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1584&targetmode=cogs STRING COG1670 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1670&targetmode=cogs SUPFAM SSF55729 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55729 UniProtKB ATDA_ECOLI http://www.uniprot.org/uniprot/ATDA_ECOLI UniProtKB-AC P0A951 http://www.uniprot.org/uniprot/P0A951 charge swissprot:ATDA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ATDA_ECOLI eggNOG COG1670 http://eggnogapi.embl.de/nog_data/html/tree/COG1670 eggNOG ENOG4108MK9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MK9 epestfind swissprot:ATDA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ATDA_ECOLI garnier swissprot:ATDA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ATDA_ECOLI helixturnhelix swissprot:ATDA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ATDA_ECOLI hmoment swissprot:ATDA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ATDA_ECOLI iep swissprot:ATDA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ATDA_ECOLI inforesidue swissprot:ATDA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ATDA_ECOLI octanol swissprot:ATDA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ATDA_ECOLI pepcoil swissprot:ATDA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ATDA_ECOLI pepdigest swissprot:ATDA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ATDA_ECOLI pepinfo swissprot:ATDA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ATDA_ECOLI pepnet swissprot:ATDA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ATDA_ECOLI pepstats swissprot:ATDA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ATDA_ECOLI pepwheel swissprot:ATDA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ATDA_ECOLI pepwindow swissprot:ATDA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ATDA_ECOLI sigcleave swissprot:ATDA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ATDA_ECOLI ## Database ID URL or Descriptions # AltName RPOZ_ECOLI RNA polymerase omega subunit # AltName RPOZ_ECOLI Transcriptase subunit omega # BioGrid 4259347 290 # CATALYTIC ACTIVITY RPOZ_ECOLI Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). # EcoGene EG10899 rpoZ # FUNCTION RPOZ_ECOLI Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0030880 RNA polymerase complex; IMP:EcoliWiki. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0003899 DNA-directed RNA polymerase activity; IEA:UniProtKB-HAMAP. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-HAMAP. # GO_process GO:0006461 protein complex assembly; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.90.940.10 -; 1. # HAMAP MF_00366 RNApol_bact_RpoZ # IntAct P0A800 26 # InterPro IPR003716 DNA-dir_RNA_pol_omega # InterPro IPR006110 Pol_omega/K/RPB6 # InterPro IPR012293 RNAP_RPB6_omega # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03021 M00183 RNA polymerase, bacteria # KEGG_Brite ko03021 Transcription machinery # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Brite ko03400 M00183 RNA polymerase, bacteria # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00240 Pyrimidine metabolism # KEGG_Pathway ko03020 RNA polymerase # Organism RPOZ_ECOLI Escherichia coli (strain K12) # PATRIC 32122785 VBIEscCol129921_3769 # PDB 3IYD EM; -; E=2-91 # PDB 3LU0 EM; -; E=1-91 # PDB 4JK1 X-ray; 3.90 A; E/J=1-91 # PDB 4JK2 X-ray; 4.20 A; E/J=1-91 # PDB 4KMU X-ray; 3.85 A; E/J=1-91 # PDB 4KN4 X-ray; 3.96 A; E/J=1-91 # PDB 4KN7 X-ray; 3.69 A; E/J=1-91 # PDB 4MEX X-ray; 3.90 A; E/K=1-91 # PDB 4MEY X-ray; 3.95 A; E/K=1-91 # PDB 4XSX X-ray; 3.71 A; E/K=1-91 # PDB 4XSY X-ray; 4.01 A; E/K=1-91 # PDB 4XSZ X-ray; 3.68 A; E/K=1-91 # PDB 4YG2 X-ray; 3.70 A; E/K=1-91 # PDB 4YLN X-ray; 5.50 A; E/K/Q=2-91 # PDB 4YLO X-ray; 6.00 A; E/K/Q=2-91 # PDB 4YLP X-ray; 5.50 A; E/K/Q=2-91 # PDB 4ZH2 X-ray; 4.20 A; E/K=1-91 # PDB 4ZH3 X-ray; 4.08 A; E/K=1-91 # PDB 4ZH4 X-ray; 3.99 A; E/K=1-91 # PDB 5BYH X-ray; 3.76 A; E=1-91 # PDB 5EZK X-ray; 8.50 A; E=1-91 # PDB 5IPL X-ray; 3.60 A; E=2-91 # PDB 5IPM X-ray; 4.20 A; E=2-91 # PDB 5IPN X-ray; 4.61 A; E=2-91 # PIR A29038 RNECO # Pfam PF01192 RNA_pol_Rpb6 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RPOZ_ECOLI DNA-directed RNA polymerase subunit omega # RefSeq NP_418106 NC_000913.3 # RefSeq WP_000135058 NZ_LN832404.1 # SIMILARITY Belongs to the RNA polymerase subunit omega family. {ECO 0000305}. # SMART SM01409 RNA_pol_Rpb6 # SUBUNIT The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. {ECO:0000269|PubMed 19903881}. # SUPFAM SSF63562 SSF63562 # TIGRFAMs TIGR00690 rpoZ # eggNOG COG1758 LUCA # eggNOG ENOG4105VFG Bacteria BLAST swissprot:RPOZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RPOZ_ECOLI BioCyc ECOL316407:JW3624-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3624-MONOMER BioCyc EcoCyc:EG10899-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10899-MONOMER COG COG1758 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1758 DIP DIP-31837N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31837N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1016/0378-1119(86)90349-5 http://dx.doi.org/10.1016/0378-1119(86)90349-5 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0908782106 http://dx.doi.org/10.1073/pnas.0908782106 DOI 10.1111/j.1574-6968.1998.tb13343.x http://dx.doi.org/10.1111/j.1574-6968.1998.tb13343.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.7.6 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.6 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M15266 http://www.ebi.ac.uk/ena/data/view/M15266 EMBL M24503 http://www.ebi.ac.uk/ena/data/view/M24503 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.7.6 http://enzyme.expasy.org/EC/2.7.7.6 EchoBASE EB0892 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0892 EcoGene EG10899 http://www.ecogene.org/geneInfo.php?eg_id=EG10899 EnsemblBacteria AAC76673 http://www.ensemblgenomes.org/id/AAC76673 EnsemblBacteria AAC76673 http://www.ensemblgenomes.org/id/AAC76673 EnsemblBacteria BAE77644 http://www.ensemblgenomes.org/id/BAE77644 EnsemblBacteria BAE77644 http://www.ensemblgenomes.org/id/BAE77644 EnsemblBacteria BAE77644 http://www.ensemblgenomes.org/id/BAE77644 EnsemblBacteria b3649 http://www.ensemblgenomes.org/id/b3649 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0030880 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030880 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003899 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003899 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.90.940.10 http://www.cathdb.info/version/latest/superfamily/3.90.940.10 GeneID 5551502 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5551502 GeneID 948160 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948160 HAMAP MF_00366 http://hamap.expasy.org/unirule/MF_00366 HOGENOM HOG000245721 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000245721&db=HOGENOM6 InParanoid P0A800 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A800 IntAct P0A800 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A800* IntEnz 2.7.7.6 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.6 InterPro IPR003716 http://www.ebi.ac.uk/interpro/entry/IPR003716 InterPro IPR006110 http://www.ebi.ac.uk/interpro/entry/IPR006110 InterPro IPR012293 http://www.ebi.ac.uk/interpro/entry/IPR012293 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03021 http://www.genome.jp/dbget-bin/www_bget?ko03021 KEGG_Brite ko03021 http://www.genome.jp/dbget-bin/www_bget?ko03021 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW3624 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3624 KEGG_Gene eco:b3649 http://www.genome.jp/dbget-bin/www_bget?eco:b3649 KEGG_Orthology KO:K03060 http://www.genome.jp/dbget-bin/www_bget?KO:K03060 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Pathway ko03020 http://www.genome.jp/kegg-bin/show_pathway?ko03020 KEGG_Reaction rn:R00435 http://www.genome.jp/dbget-bin/www_bget?rn:R00435 KEGG_Reaction rn:R00441 http://www.genome.jp/dbget-bin/www_bget?rn:R00441 KEGG_Reaction rn:R00442 http://www.genome.jp/dbget-bin/www_bget?rn:R00442 KEGG_Reaction rn:R00443 http://www.genome.jp/dbget-bin/www_bget?rn:R00443 MINT MINT-1222720 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1222720 OMA LINGQIM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LINGQIM PDB 3IYD http://www.ebi.ac.uk/pdbe-srv/view/entry/3IYD PDB 3LU0 http://www.ebi.ac.uk/pdbe-srv/view/entry/3LU0 PDB 4JK1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4JK1 PDB 4JK2 http://www.ebi.ac.uk/pdbe-srv/view/entry/4JK2 PDB 4KMU http://www.ebi.ac.uk/pdbe-srv/view/entry/4KMU PDB 4KN4 http://www.ebi.ac.uk/pdbe-srv/view/entry/4KN4 PDB 4KN7 http://www.ebi.ac.uk/pdbe-srv/view/entry/4KN7 PDB 4MEX http://www.ebi.ac.uk/pdbe-srv/view/entry/4MEX PDB 4MEY http://www.ebi.ac.uk/pdbe-srv/view/entry/4MEY PDB 4XSX http://www.ebi.ac.uk/pdbe-srv/view/entry/4XSX PDB 4XSY http://www.ebi.ac.uk/pdbe-srv/view/entry/4XSY PDB 4XSZ http://www.ebi.ac.uk/pdbe-srv/view/entry/4XSZ PDB 4YG2 http://www.ebi.ac.uk/pdbe-srv/view/entry/4YG2 PDB 4YLN http://www.ebi.ac.uk/pdbe-srv/view/entry/4YLN PDB 4YLO http://www.ebi.ac.uk/pdbe-srv/view/entry/4YLO PDB 4YLP http://www.ebi.ac.uk/pdbe-srv/view/entry/4YLP PDB 4ZH2 http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZH2 PDB 4ZH3 http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZH3 PDB 4ZH4 http://www.ebi.ac.uk/pdbe-srv/view/entry/4ZH4 PDB 5BYH http://www.ebi.ac.uk/pdbe-srv/view/entry/5BYH PDB 5EZK http://www.ebi.ac.uk/pdbe-srv/view/entry/5EZK PDB 5IPL http://www.ebi.ac.uk/pdbe-srv/view/entry/5IPL PDB 5IPM http://www.ebi.ac.uk/pdbe-srv/view/entry/5IPM PDB 5IPN http://www.ebi.ac.uk/pdbe-srv/view/entry/5IPN PDBsum 3IYD http://www.ebi.ac.uk/pdbsum/3IYD PDBsum 3LU0 http://www.ebi.ac.uk/pdbsum/3LU0 PDBsum 4JK1 http://www.ebi.ac.uk/pdbsum/4JK1 PDBsum 4JK2 http://www.ebi.ac.uk/pdbsum/4JK2 PDBsum 4KMU http://www.ebi.ac.uk/pdbsum/4KMU PDBsum 4KN4 http://www.ebi.ac.uk/pdbsum/4KN4 PDBsum 4KN7 http://www.ebi.ac.uk/pdbsum/4KN7 PDBsum 4MEX http://www.ebi.ac.uk/pdbsum/4MEX PDBsum 4MEY http://www.ebi.ac.uk/pdbsum/4MEY PDBsum 4XSX http://www.ebi.ac.uk/pdbsum/4XSX PDBsum 4XSY http://www.ebi.ac.uk/pdbsum/4XSY PDBsum 4XSZ http://www.ebi.ac.uk/pdbsum/4XSZ PDBsum 4YG2 http://www.ebi.ac.uk/pdbsum/4YG2 PDBsum 4YLN http://www.ebi.ac.uk/pdbsum/4YLN PDBsum 4YLO http://www.ebi.ac.uk/pdbsum/4YLO PDBsum 4YLP http://www.ebi.ac.uk/pdbsum/4YLP PDBsum 4ZH2 http://www.ebi.ac.uk/pdbsum/4ZH2 PDBsum 4ZH3 http://www.ebi.ac.uk/pdbsum/4ZH3 PDBsum 4ZH4 http://www.ebi.ac.uk/pdbsum/4ZH4 PDBsum 5BYH http://www.ebi.ac.uk/pdbsum/5BYH PDBsum 5EZK http://www.ebi.ac.uk/pdbsum/5EZK PDBsum 5IPL http://www.ebi.ac.uk/pdbsum/5IPL PDBsum 5IPM http://www.ebi.ac.uk/pdbsum/5IPM PDBsum 5IPN http://www.ebi.ac.uk/pdbsum/5IPN PSORT swissprot:RPOZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RPOZ_ECOLI PSORT-B swissprot:RPOZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RPOZ_ECOLI PSORT2 swissprot:RPOZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RPOZ_ECOLI Pfam PF01192 http://pfam.xfam.org/family/PF01192 Phobius swissprot:RPOZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RPOZ_ECOLI PhylomeDB P0A800 http://phylomedb.org/?seqid=P0A800 ProteinModelPortal P0A800 http://www.proteinmodelportal.org/query/uniprot/P0A800 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19903881 http://www.ncbi.nlm.nih.gov/pubmed/19903881 PubMed 2549050 http://www.ncbi.nlm.nih.gov/pubmed/2549050 PubMed 3549461 http://www.ncbi.nlm.nih.gov/pubmed/3549461 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9868784 http://www.ncbi.nlm.nih.gov/pubmed/9868784 RefSeq NP_418106 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418106 RefSeq WP_000135058 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000135058 SMART SM01409 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01409 SMR P0A800 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A800 STRING 511145.b3649 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3649&targetmode=cogs STRING COG1758 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1758&targetmode=cogs SUPFAM SSF63562 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63562 TIGRFAMs TIGR00690 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00690 UniProtKB RPOZ_ECOLI http://www.uniprot.org/uniprot/RPOZ_ECOLI UniProtKB-AC P0A800 http://www.uniprot.org/uniprot/P0A800 charge swissprot:RPOZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RPOZ_ECOLI eggNOG COG1758 http://eggnogapi.embl.de/nog_data/html/tree/COG1758 eggNOG ENOG4105VFG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VFG epestfind swissprot:RPOZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RPOZ_ECOLI garnier swissprot:RPOZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RPOZ_ECOLI helixturnhelix swissprot:RPOZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RPOZ_ECOLI hmoment swissprot:RPOZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RPOZ_ECOLI iep swissprot:RPOZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RPOZ_ECOLI inforesidue swissprot:RPOZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RPOZ_ECOLI octanol swissprot:RPOZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RPOZ_ECOLI pepcoil swissprot:RPOZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RPOZ_ECOLI pepdigest swissprot:RPOZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RPOZ_ECOLI pepinfo swissprot:RPOZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RPOZ_ECOLI pepnet swissprot:RPOZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RPOZ_ECOLI pepstats swissprot:RPOZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RPOZ_ECOLI pepwheel swissprot:RPOZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RPOZ_ECOLI pepwindow swissprot:RPOZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RPOZ_ECOLI sigcleave swissprot:RPOZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RPOZ_ECOLI ## Database ID URL or Descriptions # BioGrid 4259436 5 # EcoGene EG10070 argR # FUNCTION ARGR_ECOLI Negatively controls the expression of the four operons of arginine biosynthesis in addition to the carAB operon. Predominantly interacts with A/T residues in ARG boxes. It also binds to a specific site in cer locus. Thus it is essential for cer-mediated site-specific recombination in ColE1. It is necessary for monomerization of the plasmid ColE1. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0034618 arginine binding; IEA:InterPro. # GO_function GO:0044212 transcription regulatory region DNA binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006526 arginine biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0042150 plasmid recombination; IMP:EcoliWiki. # GO_process GO:0051259 protein oligomerization; IEA:InterPro. # GO_process GO:2000143 negative regulation of DNA-templated transcription, initiation; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # Gene3D 3.30.1360.40 -; 1. # HAMAP MF_00173 Arg_repressor # IntAct P0A6D0 5 # InterPro IPR001669 Arg_repress # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR020899 Arg_repress_C # InterPro IPR020900 Arg_repress_DNA-bd # InterPro IPR024946 Arg_repress_C-like # KEGG_Brite ko03000 Transcription factors # Organism ARGR_ECOLI Escherichia coli (strain K12) # PATHWAY ARGR_ECOLI Amino-acid biosynthesis; L-arginine biosynthesis [regulation]. # PATRIC 32121900 VBIEscCol129921_3334 # PDB 1AOY NMR; -; A=1-78 # PDB 1XXA X-ray; 2.20 A; A/B/C/D/E/F=80-156 # PDB 1XXB X-ray; 2.60 A; A/B/C/D/E/F=80-156 # PDB 1XXC X-ray; 2.80 A; A/B/C/D/E/F=80-156 # PIR A33888 A33888 # PRINTS PR01467 ARGREPRESSOR # Pfam PF01316 Arg_repressor # Pfam PF02863 Arg_repressor_C # ProDom PD007402 Arg_repress # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ARGR_ECOLI Arginine repressor # RefSeq NP_417704 NC_000913.3 # RefSeq WP_001257846 NZ_LN832404.1 # SIMILARITY Belongs to the ArgR family. {ECO 0000305}. # SUBCELLULAR LOCATION ARGR_ECOLI Cytoplasm. # SUBUNIT ARGR_ECOLI Homohexamer. # SUPFAM SSF46785 SSF46785 # SUPFAM SSF55252 SSF55252 # TIGRFAMs TIGR01529 argR_whole # eggNOG COG1438 LUCA # eggNOG ENOG410682Y Bacteria BLAST swissprot:ARGR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ARGR_ECOLI BioCyc ECOL316407:JW3206-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3206-MONOMER BioCyc EcoCyc:PD00194 http://biocyc.org/getid?id=EcoCyc:PD00194 COG COG1438 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1438 DIP DIP-47999N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47999N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/jmbi.1995.0607 http://dx.doi.org/10.1006/jmbi.1995.0607 DOI 10.1006/jmbi.1996.0093 http://dx.doi.org/10.1006/jmbi.1996.0093 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb1097-819 http://dx.doi.org/10.1038/nsb1097-819 DOI 10.1073/pnas.84.19.6697 http://dx.doi.org/10.1073/pnas.84.19.6697 DOI 10.1111/j.1365-2958.1994.tb00454.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb00454.x DOI 10.1111/j.1365-2958.1994.tb00455.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb00455.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M17532 http://www.ebi.ac.uk/ena/data/view/M17532 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X13968 http://www.ebi.ac.uk/ena/data/view/X13968 EchoBASE EB0068 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0068 EcoGene EG10070 http://www.ecogene.org/geneInfo.php?eg_id=EG10070 EnsemblBacteria AAC76269 http://www.ensemblgenomes.org/id/AAC76269 EnsemblBacteria AAC76269 http://www.ensemblgenomes.org/id/AAC76269 EnsemblBacteria BAE77280 http://www.ensemblgenomes.org/id/BAE77280 EnsemblBacteria BAE77280 http://www.ensemblgenomes.org/id/BAE77280 EnsemblBacteria BAE77280 http://www.ensemblgenomes.org/id/BAE77280 EnsemblBacteria b3237 http://www.ensemblgenomes.org/id/b3237 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0034618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034618 GO_function GO:0044212 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044212 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006526 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006526 GO_process GO:0042150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042150 GO_process GO:0051259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051259 GO_process GO:2000143 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000143 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 3.30.1360.40 http://www.cathdb.info/version/latest/superfamily/3.30.1360.40 GeneID 947861 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947861 HAMAP MF_00173 http://hamap.expasy.org/unirule/MF_00173 HOGENOM HOG000242730 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000242730&db=HOGENOM6 InParanoid P0A6D0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A6D0 IntAct P0A6D0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A6D0* InterPro IPR001669 http://www.ebi.ac.uk/interpro/entry/IPR001669 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR020899 http://www.ebi.ac.uk/interpro/entry/IPR020899 InterPro IPR020900 http://www.ebi.ac.uk/interpro/entry/IPR020900 InterPro IPR024946 http://www.ebi.ac.uk/interpro/entry/IPR024946 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW3206 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3206 KEGG_Gene eco:b3237 http://www.genome.jp/dbget-bin/www_bget?eco:b3237 KEGG_Orthology KO:K03402 http://www.genome.jp/dbget-bin/www_bget?KO:K03402 MINT MINT-1252219 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1252219 OMA LNQERFG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LNQERFG PDB 1AOY http://www.ebi.ac.uk/pdbe-srv/view/entry/1AOY PDB 1XXA http://www.ebi.ac.uk/pdbe-srv/view/entry/1XXA PDB 1XXB http://www.ebi.ac.uk/pdbe-srv/view/entry/1XXB PDB 1XXC http://www.ebi.ac.uk/pdbe-srv/view/entry/1XXC PDBsum 1AOY http://www.ebi.ac.uk/pdbsum/1AOY PDBsum 1XXA http://www.ebi.ac.uk/pdbsum/1XXA PDBsum 1XXB http://www.ebi.ac.uk/pdbsum/1XXB PDBsum 1XXC http://www.ebi.ac.uk/pdbsum/1XXC PRINTS PR01467 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01467 PSORT swissprot:ARGR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ARGR_ECOLI PSORT-B swissprot:ARGR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ARGR_ECOLI PSORT2 swissprot:ARGR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ARGR_ECOLI Pfam PF01316 http://pfam.xfam.org/family/PF01316 Pfam PF02863 http://pfam.xfam.org/family/PF02863 Phobius swissprot:ARGR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ARGR_ECOLI PhylomeDB P0A6D0 http://phylomedb.org/?seqid=P0A6D0 ProteinModelPortal P0A6D0 http://www.proteinmodelportal.org/query/uniprot/P0A6D0 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3116542 http://www.ncbi.nlm.nih.gov/pubmed/3116542 PubMed 3149585 http://www.ncbi.nlm.nih.gov/pubmed/3149585 PubMed 7490739 http://www.ncbi.nlm.nih.gov/pubmed/7490739 PubMed 7997172 http://www.ncbi.nlm.nih.gov/pubmed/7997172 PubMed 7997173 http://www.ncbi.nlm.nih.gov/pubmed/7997173 PubMed 8594204 http://www.ncbi.nlm.nih.gov/pubmed/8594204 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9334747 http://www.ncbi.nlm.nih.gov/pubmed/9334747 RefSeq NP_417704 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417704 RefSeq WP_001257846 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001257846 SMR P0A6D0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A6D0 STRING 511145.b3237 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3237&targetmode=cogs STRING COG1438 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1438&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SUPFAM SSF55252 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55252 TIGRFAMs TIGR01529 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01529 UniProtKB ARGR_ECOLI http://www.uniprot.org/uniprot/ARGR_ECOLI UniProtKB-AC P0A6D0 http://www.uniprot.org/uniprot/P0A6D0 charge swissprot:ARGR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ARGR_ECOLI eggNOG COG1438 http://eggnogapi.embl.de/nog_data/html/tree/COG1438 eggNOG ENOG410682Y http://eggnogapi.embl.de/nog_data/html/tree/ENOG410682Y epestfind swissprot:ARGR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ARGR_ECOLI garnier swissprot:ARGR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ARGR_ECOLI helixturnhelix swissprot:ARGR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ARGR_ECOLI hmoment swissprot:ARGR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ARGR_ECOLI iep swissprot:ARGR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ARGR_ECOLI inforesidue swissprot:ARGR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ARGR_ECOLI octanol swissprot:ARGR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ARGR_ECOLI pepcoil swissprot:ARGR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ARGR_ECOLI pepdigest swissprot:ARGR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ARGR_ECOLI pepinfo swissprot:ARGR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ARGR_ECOLI pepnet swissprot:ARGR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ARGR_ECOLI pepstats swissprot:ARGR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ARGR_ECOLI pepwheel swissprot:ARGR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ARGR_ECOLI pepwindow swissprot:ARGR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ARGR_ECOLI sigcleave swissprot:ARGR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ARGR_ECOLI ## Database ID URL or Descriptions # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_process GO:0006310 DNA recombination; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0015074 DNA integration; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.443.10 -; 1. # InterPro IPR002104 Integrase_catalytic # InterPro IPR011010 DNA_brk_join_enz # InterPro IPR013762 Integrase-like_cat # InterPro IPR016423 Resolvase_Rsv # Organism INTM_ECOLI Escherichia coli (strain K12) # PIRSF PIRSF004576 Resolvase_Rsv # Pfam PF00589 Phage_integrase # RecName INTM_ECOLI Probable site-specific recombinase # RefSeq NP_061411 NC_002483.1 # RefSeq WP_001066941 NZ_CP014273.1 # SIMILARITY Belongs to the 'phage' integrase family. {ECO 0000305}. # SUPFAM SSF56349 SSF56349 BLAST swissprot:INTM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INTM_ECOLI EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0015074 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015074 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.443.10 http://www.cathdb.info/version/latest/superfamily/1.10.443.10 GeneID 1263535 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263535 InterPro IPR002104 http://www.ebi.ac.uk/interpro/entry/IPR002104 InterPro IPR011010 http://www.ebi.ac.uk/interpro/entry/IPR011010 InterPro IPR013762 http://www.ebi.ac.uk/interpro/entry/IPR013762 InterPro IPR016423 http://www.ebi.ac.uk/interpro/entry/IPR016423 OMA HKDPRSM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HKDPRSM PSORT swissprot:INTM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INTM_ECOLI PSORT-B swissprot:INTM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INTM_ECOLI PSORT2 swissprot:INTM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INTM_ECOLI Pfam PF00589 http://pfam.xfam.org/family/PF00589 Phobius swissprot:INTM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INTM_ECOLI PhylomeDB P56979 http://phylomedb.org/?seqid=P56979 ProteinModelPortal P56979 http://www.proteinmodelportal.org/query/uniprot/P56979 RefSeq NP_061411 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061411 RefSeq WP_001066941 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001066941 SUPFAM SSF56349 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56349 UniProtKB INTM_ECOLI http://www.uniprot.org/uniprot/INTM_ECOLI UniProtKB-AC P56979 http://www.uniprot.org/uniprot/P56979 charge swissprot:INTM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INTM_ECOLI epestfind swissprot:INTM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INTM_ECOLI garnier swissprot:INTM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INTM_ECOLI helixturnhelix swissprot:INTM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INTM_ECOLI hmoment swissprot:INTM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INTM_ECOLI iep swissprot:INTM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INTM_ECOLI inforesidue swissprot:INTM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INTM_ECOLI octanol swissprot:INTM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INTM_ECOLI pepcoil swissprot:INTM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INTM_ECOLI pepdigest swissprot:INTM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INTM_ECOLI pepinfo swissprot:INTM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INTM_ECOLI pepnet swissprot:INTM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INTM_ECOLI pepstats swissprot:INTM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INTM_ECOLI pepwheel swissprot:INTM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INTM_ECOLI pepwindow swissprot:INTM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INTM_ECOLI sigcleave swissprot:INTM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INTM_ECOLI ## Database ID URL or Descriptions # EcoGene EG10920 rpsU # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0022627 cytosolic small ribosomal subunit; IDA:EcoliWiki. # GO_function GO:0003735 structural constituent of ribosome; IEA:InterPro. # GO_process GO:0006412 translation; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_process GO:0006412 translation # HAMAP MF_00358 Ribosomal_S21 # IntAct P68679 23 # InterPro IPR001911 Ribosomal_S21 # InterPro IPR018278 Ribosomal_S21_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=8368.8; Method=MALDI; Range=2-71; Evidence={ECO:0000269|PubMed 10094780}; # Organism RS21_ECOLI Escherichia coli (strain K12) # PATRIC 32121544 VBIEscCol129921_3159 # PDB 2YKR EM; 9.80 A; U=4-54 # PDB 3J9Y EM; 3.90 A; u=1-71 # PDB 3J9Z EM; 3.60 A; SU=2-71 # PDB 3JA1 EM; 3.60 A; SU=2-71 # PDB 3JBU EM; 3.64 A; U=1-71 # PDB 3JBV EM; 3.32 A; U=1-71 # PDB 3JCD EM; 3.70 A; u=1-71 # PDB 3JCE EM; 3.20 A; u=1-71 # PDB 3JCJ EM; 3.70 A; 2=1-71 # PDB 3JCN EM; 4.60 A; w=1-71 # PDB 4A2I EM; 16.50 A; U=4-54 # PDB 4ADV EM; 13.50 A; U=1-71 # PDB 4U1U X-ray; 2.95 A; AU/CU=4-54 # PDB 4U1V X-ray; 3.00 A; AU/CU=4-54 # PDB 4U20 X-ray; 2.90 A; AU/CU=4-54 # PDB 4U24 X-ray; 2.90 A; AU/CU=4-54 # PDB 4U25 X-ray; 2.90 A; AU/CU=4-54 # PDB 4U26 X-ray; 2.80 A; AU/CU=4-54 # PDB 4U27 X-ray; 2.80 A; AU/CU=4-54 # PDB 4V4H X-ray; 3.46 A; AU/CU=1-71 # PDB 4V4Q X-ray; 3.46 A; AU/CU=1-71 # PDB 4V50 X-ray; 3.22 A; AU/CU=2-71 # PDB 4V52 X-ray; 3.21 A; AU/CU=2-71 # PDB 4V53 X-ray; 3.54 A; AU/CU=2-71 # PDB 4V54 X-ray; 3.30 A; AU/CU=2-71 # PDB 4V55 X-ray; 4.00 A; AU/CU=2-71 # PDB 4V56 X-ray; 3.93 A; AU/CU=2-71 # PDB 4V57 X-ray; 3.50 A; AU/CU=2-71 # PDB 4V5B X-ray; 3.74 A; BU/DU=1-71 # PDB 4V5H EM; 5.80 A; AU=4-54 # PDB 4V5Y X-ray; 4.45 A; AU/CU=2-71 # PDB 4V64 X-ray; 3.50 A; AU/CU=1-71 # PDB 4V65 EM; 9.00 A; AQ=1-71 # PDB 4V66 EM; 9.00 A; AQ=1-71 # PDB 4V69 EM; 6.70 A; AU=4-54 # PDB 4V6C X-ray; 3.19 A; AU/CU=1-71 # PDB 4V6D X-ray; 3.81 A; AU/CU=1-71 # PDB 4V6E X-ray; 3.71 A; AU/CU=1-71 # PDB 4V6K EM; 8.25 A; BY=1-71 # PDB 4V6L EM; 13.20 A; AY=1-71 # PDB 4V6M EM; 7.10 A; AU=2-71 # PDB 4V6N EM; 12.10 A; BX=2-71 # PDB 4V6O EM; 14.70 A; AX=2-71 # PDB 4V6P EM; 13.50 A; AX=2-71 # PDB 4V6Q EM; 11.50 A; AX=2-71 # PDB 4V6R EM; 11.50 A; AX=2-71 # PDB 4V6S EM; 13.10 A; BW=2-71 # PDB 4V6T EM; 8.30 A; AU=4-54 # PDB 4V6V EM; 9.80 A; AU=2-71 # PDB 4V6Y EM; 12.00 A; AU=4-54 # PDB 4V6Z EM; 12.00 A; AU=4-54 # PDB 4V70 EM; 17.00 A; AU=4-54 # PDB 4V71 EM; 20.00 A; AU=4-54 # PDB 4V72 EM; 13.00 A; AU=4-54 # PDB 4V73 EM; 15.00 A; AU=4-54 # PDB 4V74 EM; 17.00 A; AU=4-54 # PDB 4V75 EM; 12.00 A; AU=4-54 # PDB 4V76 EM; 17.00 A; AU=4-54 # PDB 4V77 EM; 17.00 A; AU=4-54 # PDB 4V78 EM; 20.00 A; AU=4-54 # PDB 4V79 EM; 15.00 A; AU=4-54 # PDB 4V7A EM; 9.00 A; AU=4-54 # PDB 4V7B EM; 6.80 A; AU=1-71 # PDB 4V7C EM; 7.60 A; AU=2-71 # PDB 4V7D EM; 7.60 A; BU=2-71 # PDB 4V7I EM; 9.60 A; BU=1-71 # PDB 4V7S X-ray; 3.25 A; AU/CU=4-54 # PDB 4V7T X-ray; 3.19 A; AU/CU=4-54 # PDB 4V7U X-ray; 3.10 A; AU/CU=4-54 # PDB 4V7V X-ray; 3.29 A; AU/CU=4-54 # PDB 4V85 X-ray; 3.20 A; U=1-71 # PDB 4V89 X-ray; 3.70 A; AU=1-71 # PDB 4V9C X-ray; 3.30 A; AU/CU=1-71 # PDB 4V9D X-ray; 3.00 A; AU/BU=4-54 # PDB 4V9O X-ray; 2.90 A; BU/DU/FU/HU=1-71 # PDB 4V9P X-ray; 2.90 A; BU/DU/FU/HU=1-71 # PDB 4WF1 X-ray; 3.09 A; AU/CU=4-54 # PDB 4WOI X-ray; 3.00 A; AU/DU=1-71 # PDB 4WWW X-ray; 3.10 A; QU/XU=4-54 # PDB 4YBB X-ray; 2.10 A; AU/BU=2-57 # PDB 5AFI EM; 2.90 A; u=1-71 # PDB 5IQR EM; 3.00 A; z=1-71 # PDB 5J5B X-ray; 2.80 A; AU/BU=2-57 # PDB 5J7L X-ray; 3.00 A; AU/BU=2-57 # PDB 5J88 X-ray; 3.32 A; AU/BU=2-57 # PDB 5J8A X-ray; 3.10 A; AU/BU=2-57 # PDB 5J91 X-ray; 2.96 A; AU/BU=2-57 # PDB 5JC9 X-ray; 3.03 A; AU/BU=2-57 # PDB 5JTE EM; 3.60 A; AU=1-71 # PDB 5JU8 EM; 3.60 A; AU=1-71 # PDB 5KCR EM; 3.60 A; 1u=1-71 # PDB 5KCS EM; 3.90 A; 1u=1-71 # PDB 5KPS EM; 3.90 A; 26=1-71 # PDB 5KPV EM; 4.10 A; 25=1-71 # PDB 5KPW EM; 3.90 A; 25=1-71 # PDB 5KPX EM; 3.90 A; 25=1-71 # PDB 5L3P EM; 3.70 A; u=1-71 # PIR A02749 R3EC21 # PRINTS PR00976 RIBOSOMALS21 # PROSITE PS01181 RIBOSOMAL_S21 # Pfam PF01165 Ribosomal_S21 # ProDom PD005521 Ribosomal_S21 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RS21_ECOLI 30S ribosomal protein S21 # RefSeq NP_417537 NC_000913.3 # RefSeq WP_001144069 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein S21P family. {ECO 0000305}. # TIGRFAMs TIGR00030 S21p # eggNOG COG0828 LUCA BLAST swissprot:RS21_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RS21_ECOLI BioCyc ECOL316407:JW3037-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3037-MONOMER BioCyc EcoCyc:EG10920-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10920-MONOMER BioCyc MetaCyc:EG10920-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10920-MONOMER COG COG0828 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0828 DIP DIP-47839N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47839N DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1007/BF00326054 http://dx.doi.org/10.1007/BF00326054 DOI 10.1016/0092-8674(83)90453-1 http://dx.doi.org/10.1016/0092-8674(83)90453-1 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01687 http://www.ebi.ac.uk/ena/data/view/J01687 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28379 http://www.ebi.ac.uk/ena/data/view/U28379 EMBL V00346 http://www.ebi.ac.uk/ena/data/view/V00346 EchoBASE EB0913 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0913 EcoGene EG10920 http://www.ecogene.org/geneInfo.php?eg_id=EG10920 EnsemblBacteria AAC76101 http://www.ensemblgenomes.org/id/AAC76101 EnsemblBacteria AAC76101 http://www.ensemblgenomes.org/id/AAC76101 EnsemblBacteria BAE77116 http://www.ensemblgenomes.org/id/BAE77116 EnsemblBacteria BAE77116 http://www.ensemblgenomes.org/id/BAE77116 EnsemblBacteria BAE77116 http://www.ensemblgenomes.org/id/BAE77116 EnsemblBacteria b3065 http://www.ensemblgenomes.org/id/b3065 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0022627 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022627 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GeneID 947577 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947577 GeneID 9732014 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9732014 HAMAP MF_00358 http://hamap.expasy.org/unirule/MF_00358 HOGENOM HOG000157460 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000157460&db=HOGENOM6 InParanoid P68679 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P68679 IntAct P68679 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P68679* InterPro IPR001911 http://www.ebi.ac.uk/interpro/entry/IPR001911 InterPro IPR018278 http://www.ebi.ac.uk/interpro/entry/IPR018278 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW3037 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3037 KEGG_Gene eco:b3065 http://www.genome.jp/dbget-bin/www_bget?eco:b3065 KEGG_Orthology KO:K02970 http://www.genome.jp/dbget-bin/www_bget?KO:K02970 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 MINT MINT-1281887 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1281887 OMA RFKRSCA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RFKRSCA PDB 2YKR http://www.ebi.ac.uk/pdbe-srv/view/entry/2YKR PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 4A2I http://www.ebi.ac.uk/pdbe-srv/view/entry/4A2I PDB 4ADV http://www.ebi.ac.uk/pdbe-srv/view/entry/4ADV PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 2YKR http://www.ebi.ac.uk/pdbsum/2YKR PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 4A2I http://www.ebi.ac.uk/pdbsum/4A2I PDBsum 4ADV http://www.ebi.ac.uk/pdbsum/4ADV PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PRINTS PR00976 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00976 PROSITE PS01181 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01181 PSORT swissprot:RS21_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RS21_ECOLI PSORT-B swissprot:RS21_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RS21_ECOLI PSORT2 swissprot:RS21_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RS21_ECOLI Pfam PF01165 http://pfam.xfam.org/family/PF01165 Phobius swissprot:RS21_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RS21_ECOLI PhylomeDB P68679 http://phylomedb.org/?seqid=P68679 ProteinModelPortal P68679 http://www.proteinmodelportal.org/query/uniprot/P68679 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6186393 http://www.ncbi.nlm.nih.gov/pubmed/6186393 PubMed 6222240 http://www.ncbi.nlm.nih.gov/pubmed/6222240 PubMed 7556101 http://www.ncbi.nlm.nih.gov/pubmed/7556101 PubMed 765257 http://www.ncbi.nlm.nih.gov/pubmed/765257 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417537 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417537 RefSeq WP_001144069 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001144069 SMR P68679 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P68679 STRING 511145.b3065 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3065&targetmode=cogs STRING COG0828 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0828&targetmode=cogs TIGRFAMs TIGR00030 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00030 UniProtKB RS21_ECOLI http://www.uniprot.org/uniprot/RS21_ECOLI UniProtKB-AC P68679 http://www.uniprot.org/uniprot/P68679 charge swissprot:RS21_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RS21_ECOLI eggNOG COG0828 http://eggnogapi.embl.de/nog_data/html/tree/COG0828 epestfind swissprot:RS21_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RS21_ECOLI garnier swissprot:RS21_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RS21_ECOLI helixturnhelix swissprot:RS21_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RS21_ECOLI hmoment swissprot:RS21_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RS21_ECOLI iep swissprot:RS21_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RS21_ECOLI inforesidue swissprot:RS21_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RS21_ECOLI octanol swissprot:RS21_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RS21_ECOLI pepcoil swissprot:RS21_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RS21_ECOLI pepdigest swissprot:RS21_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RS21_ECOLI pepinfo swissprot:RS21_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RS21_ECOLI pepnet swissprot:RS21_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RS21_ECOLI pepstats swissprot:RS21_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RS21_ECOLI pepwheel swissprot:RS21_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RS21_ECOLI pepwindow swissprot:RS21_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RS21_ECOLI sigcleave swissprot:RS21_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RS21_ECOLI ## Database ID URL or Descriptions # AltName BIOA_ECOLI 7,8-diamino-pelargonic acid aminotransferase # AltName BIOA_ECOLI 7,8-diaminononanoate synthase # AltName BIOA_ECOLI Diaminopelargonic acid synthase # BIOPHYSICOCHEMICAL PROPERTIES BIOA_ECOLI Kinetic parameters KM=1.2 uM for KAPA {ECO 0000269|PubMed 1092682, ECO 0000269|PubMed 12379100}; KM=150 uM for SAM {ECO 0000269|PubMed 1092682, ECO 0000269|PubMed 12379100}; KM=21 uM for pyridoxamine phosphate (PMP) {ECO 0000269|PubMed 1092682, ECO 0000269|PubMed 12379100}; KM=32 uM for pyridoxal phosphate (PLP) {ECO 0000269|PubMed 1092682, ECO 0000269|PubMed 12379100}; KM=1000 uM for 8-keto-7-aminopelargonic acid {ECO 0000269|PubMed 1092682, ECO 0000269|PubMed 12379100}; Vmax=0.16 umol/min/mg enzyme with KAPA as substrate {ECO 0000269|PubMed 1092682, ECO 0000269|PubMed 12379100}; Vmax=0.027 umol/min/mg enzyme with 8-keto-7-aminopelargonic acid as substrate {ECO 0000269|PubMed 1092682, ECO 0000269|PubMed 12379100}; # BRENDA 2.6.1.62 2026 # BioGrid 4261841 13 # CATALYTIC ACTIVITY BIOA_ECOLI S-adenosyl-L-methionine + 8-amino-7- oxononanoate = S-adenosyl-4-methylthio-2-oxobutanoate + 7,8- diaminononanoate. # CDD cd00610 OAT_like # COFACTOR BIOA_ECOLI Name=pyridoxal 5'-phosphate; Xref=ChEBI CHEBI 597326; Evidence={ECO 0000269|PubMed 1092681}; # ENZYME REGULATION BIOA_ECOLI Inhibited by amiclenomycin. S-adenosyl-L-(2- hydroxy-4-methylthio)butyric acid and adenosine are competitive inhibitors with SAM and uncompetitive inhibitors with KAPA as substrates. S-adenosyl-L-ethionine, adenine and 8-keto-7- aminopelargonic acid are non-competitive inhibitors with both substrates. {ECO 0000269|PubMed 1092682, ECO 0000269|PubMed 12218056, ECO 0000269|PubMed 16042602}. # EcoGene EG10117 bioA # FUNCTION BIOA_ECOLI Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor. {ECO 0000269|PubMed 1092681}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0004015 adenosylmethionine-8-amino-7-oxononanoate transaminase activity; IDA:UniProtKB. # GO_function GO:0030170 pyridoxal phosphate binding; IDA:UniProtKB. # GO_function GO:0042802 identical protein binding; IBA:GO_Central. # GO_process GO:0009102 biotin biosynthetic process; IDA:UniProtKB. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.640.10 -; 1. # Gene3D 3.90.1150.10 -; 2. # HAMAP MF_00834 BioA # INDUCTION Repressed by BirA. {ECO:0000269|PubMed 6456358}. # IntAct P12995 5 # InterPro IPR005814 Aminotrans_3 # InterPro IPR005815 BioA # InterPro IPR015421 PyrdxlP-dep_Trfase_major_sub1 # InterPro IPR015422 PyrdxlP-dep_Trfase_major_sub2 # InterPro IPR015424 PyrdxlP-dep_Trfase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01007 Amino acid related enzymes # KEGG_Pathway ko00780 Biotin metabolism # MISCELLANEOUS BIOA_ECOLI Catalysis proceeds by a classical ping-pong bi-bi reaction mechanism. # Organism BIOA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11986 PTHR11986 # PATHWAY Cofactor biosynthesis; biotin biosynthesis; 7,8- diaminononanoate from 8-amino-7-oxononanoate (SAM route) step 1/1. # PATRIC 32116749 VBIEscCol129921_0800 # PDB 1DTY X-ray; 2.14 A; A/B=1-429 # PDB 1MGV X-ray; 2.10 A; A/B=1-429 # PDB 1MLY X-ray; 1.81 A; A/B=1-429 # PDB 1MLZ X-ray; 2.15 A; A/B=1-429 # PDB 1QJ3 X-ray; 2.70 A; A/B=1-429 # PDB 1QJ5 X-ray; 1.80 A; A/B=1-429 # PDB 1S06 X-ray; 2.20 A; A/B=1-429 # PDB 1S07 X-ray; 2.42 A; A/B=1-429 # PDB 1S08 X-ray; 2.10 A; A/B=1-429 # PDB 1S09 X-ray; 1.83 A; A/B=1-429 # PDB 1S0A X-ray; 1.71 A; A/B=1-429 # PIR F64813 XNECDP # PIRSF PIRSF000521 Transaminase_4ab_Lys_Orn # PROSITE PS00600 AA_TRANSFER_CLASS_3 # Pfam PF00202 Aminotran_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BIOA_ECOLI Adenosylmethionine-8-amino-7-oxononanoate aminotransferase # RefSeq NP_415295 NC_000913.3 # SIMILARITY Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION BIOA_ECOLI Cytoplasm {ECO 0000250}. # SUBUNIT BIOA_ECOLI Homodimer. {ECO 0000269|PubMed 10452893, ECO 0000269|PubMed 1092681, ECO 0000269|PubMed 12218056, ECO 0000269|PubMed 12379100, ECO 0000269|PubMed 14756557}. # SUPFAM SSF53383 SSF53383 # TIGRFAMs TIGR00508 bioA # UniPathway UPA00078 UER00160 # eggNOG COG0161 LUCA # eggNOG ENOG4108JPX Bacteria BLAST swissprot:BIOA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BIOA_ECOLI BioCyc ECOL316407:JW0757-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0757-MONOMER BioCyc EcoCyc:DAPASYN-MONOMER http://biocyc.org/getid?id=EcoCyc:DAPASYN-MONOMER BioCyc MetaCyc:DAPASYN-MONOMER http://biocyc.org/getid?id=MetaCyc:DAPASYN-MONOMER COG COG0161 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0161 DIP DIP-9219N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9219N DOI 10.1006/jmbi.1999.2997 http://dx.doi.org/10.1006/jmbi.1999.2997 DOI 10.1016/0022-2836(81)90043-7 http://dx.doi.org/10.1016/0022-2836(81)90043-7 DOI 10.1021/bi026339a http://dx.doi.org/10.1021/bi026339a DOI 10.1021/bi0358059 http://dx.doi.org/10.1021/bi0358059 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nchembio.420 http://dx.doi.org/10.1038/nchembio.420 DOI 10.1042/BST0330802 http://dx.doi.org/10.1042/BST0330802 DOI 10.1074/jbc.M207239200 http://dx.doi.org/10.1074/jbc.M207239200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.6.1.62 http://www.genome.jp/dbget-bin/www_bget?EC:2.6.1.62 EMBL A11524 http://www.ebi.ac.uk/ena/data/view/A11524 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J04423 http://www.ebi.ac.uk/ena/data/view/J04423 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.6.1.62 http://enzyme.expasy.org/EC/2.6.1.62 EchoBASE EB0115 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0115 EcoGene EG10117 http://www.ecogene.org/geneInfo.php?eg_id=EG10117 EnsemblBacteria AAC73861 http://www.ensemblgenomes.org/id/AAC73861 EnsemblBacteria AAC73861 http://www.ensemblgenomes.org/id/AAC73861 EnsemblBacteria BAE76361 http://www.ensemblgenomes.org/id/BAE76361 EnsemblBacteria BAE76361 http://www.ensemblgenomes.org/id/BAE76361 EnsemblBacteria BAE76361 http://www.ensemblgenomes.org/id/BAE76361 EnsemblBacteria b0774 http://www.ensemblgenomes.org/id/b0774 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004015 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004015 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0009102 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009102 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.640.10 http://www.cathdb.info/version/latest/superfamily/3.40.640.10 Gene3D 3.90.1150.10 http://www.cathdb.info/version/latest/superfamily/3.90.1150.10 GeneID 945376 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945376 HAMAP MF_00834 http://hamap.expasy.org/unirule/MF_00834 HOGENOM HOG000020209 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000020209&db=HOGENOM6 InParanoid P12995 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P12995 IntAct P12995 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P12995* IntEnz 2.6.1.62 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.6.1.62 InterPro IPR005814 http://www.ebi.ac.uk/interpro/entry/IPR005814 InterPro IPR005815 http://www.ebi.ac.uk/interpro/entry/IPR005815 InterPro IPR015421 http://www.ebi.ac.uk/interpro/entry/IPR015421 InterPro IPR015422 http://www.ebi.ac.uk/interpro/entry/IPR015422 InterPro IPR015424 http://www.ebi.ac.uk/interpro/entry/IPR015424 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Gene ecj:JW0757 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0757 KEGG_Gene eco:b0774 http://www.genome.jp/dbget-bin/www_bget?eco:b0774 KEGG_Orthology KO:K00833 http://www.genome.jp/dbget-bin/www_bget?KO:K00833 KEGG_Pathway ko00780 http://www.genome.jp/kegg-bin/show_pathway?ko00780 KEGG_Reaction rn:R03231 http://www.genome.jp/dbget-bin/www_bget?rn:R03231 MINT MINT-1275136 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1275136 OMA ANPRINQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ANPRINQ PANTHER PTHR11986 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11986 PDB 1DTY http://www.ebi.ac.uk/pdbe-srv/view/entry/1DTY PDB 1MGV http://www.ebi.ac.uk/pdbe-srv/view/entry/1MGV PDB 1MLY http://www.ebi.ac.uk/pdbe-srv/view/entry/1MLY PDB 1MLZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1MLZ PDB 1QJ3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1QJ3 PDB 1QJ5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1QJ5 PDB 1S06 http://www.ebi.ac.uk/pdbe-srv/view/entry/1S06 PDB 1S07 http://www.ebi.ac.uk/pdbe-srv/view/entry/1S07 PDB 1S08 http://www.ebi.ac.uk/pdbe-srv/view/entry/1S08 PDB 1S09 http://www.ebi.ac.uk/pdbe-srv/view/entry/1S09 PDB 1S0A http://www.ebi.ac.uk/pdbe-srv/view/entry/1S0A PDBsum 1DTY http://www.ebi.ac.uk/pdbsum/1DTY PDBsum 1MGV http://www.ebi.ac.uk/pdbsum/1MGV PDBsum 1MLY http://www.ebi.ac.uk/pdbsum/1MLY PDBsum 1MLZ http://www.ebi.ac.uk/pdbsum/1MLZ PDBsum 1QJ3 http://www.ebi.ac.uk/pdbsum/1QJ3 PDBsum 1QJ5 http://www.ebi.ac.uk/pdbsum/1QJ5 PDBsum 1S06 http://www.ebi.ac.uk/pdbsum/1S06 PDBsum 1S07 http://www.ebi.ac.uk/pdbsum/1S07 PDBsum 1S08 http://www.ebi.ac.uk/pdbsum/1S08 PDBsum 1S09 http://www.ebi.ac.uk/pdbsum/1S09 PDBsum 1S0A http://www.ebi.ac.uk/pdbsum/1S0A PROSITE PS00600 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00600 PSORT swissprot:BIOA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BIOA_ECOLI PSORT-B swissprot:BIOA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BIOA_ECOLI PSORT2 swissprot:BIOA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BIOA_ECOLI Pfam PF00202 http://pfam.xfam.org/family/PF00202 Phobius swissprot:BIOA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BIOA_ECOLI PhylomeDB P12995 http://phylomedb.org/?seqid=P12995 ProteinModelPortal P12995 http://www.proteinmodelportal.org/query/uniprot/P12995 PubMed 10452893 http://www.ncbi.nlm.nih.gov/pubmed/10452893 PubMed 1092681 http://www.ncbi.nlm.nih.gov/pubmed/1092681 PubMed 1092682 http://www.ncbi.nlm.nih.gov/pubmed/1092682 PubMed 12218056 http://www.ncbi.nlm.nih.gov/pubmed/12218056 PubMed 12379100 http://www.ncbi.nlm.nih.gov/pubmed/12379100 PubMed 14756557 http://www.ncbi.nlm.nih.gov/pubmed/14756557 PubMed 16042602 http://www.ncbi.nlm.nih.gov/pubmed/16042602 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20693992 http://www.ncbi.nlm.nih.gov/pubmed/20693992 PubMed 3058702 http://www.ncbi.nlm.nih.gov/pubmed/3058702 PubMed 6456358 http://www.ncbi.nlm.nih.gov/pubmed/6456358 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415295 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415295 SMR P12995 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P12995 STRING 511145.b0774 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0774&targetmode=cogs STRING COG0161 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0161&targetmode=cogs SUPFAM SSF53383 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53383 TIGRFAMs TIGR00508 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00508 UniProtKB BIOA_ECOLI http://www.uniprot.org/uniprot/BIOA_ECOLI UniProtKB-AC P12995 http://www.uniprot.org/uniprot/P12995 charge swissprot:BIOA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BIOA_ECOLI eggNOG COG0161 http://eggnogapi.embl.de/nog_data/html/tree/COG0161 eggNOG ENOG4108JPX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108JPX epestfind swissprot:BIOA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BIOA_ECOLI garnier swissprot:BIOA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BIOA_ECOLI helixturnhelix swissprot:BIOA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BIOA_ECOLI hmoment swissprot:BIOA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BIOA_ECOLI iep swissprot:BIOA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BIOA_ECOLI inforesidue swissprot:BIOA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BIOA_ECOLI octanol swissprot:BIOA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BIOA_ECOLI pepcoil swissprot:BIOA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BIOA_ECOLI pepdigest swissprot:BIOA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BIOA_ECOLI pepinfo swissprot:BIOA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BIOA_ECOLI pepnet swissprot:BIOA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BIOA_ECOLI pepstats swissprot:BIOA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BIOA_ECOLI pepwheel swissprot:BIOA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BIOA_ECOLI pepwindow swissprot:BIOA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BIOA_ECOLI sigcleave swissprot:BIOA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BIOA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260700 117 # EcoGene EG12195 torD # FUNCTION TORD_ECOLI Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor. {ECO 0000269|PubMed 12766163, ECO 0000269|PubMed 9632735}. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_function GO:0042277 peptide binding; IMP:EcoliWiki. # GO_function GO:0042802 identical protein binding; IPI:IntAct. # GO_function GO:0043546 molybdopterin cofactor binding; IMP:EcoliWiki. # GO_process GO:0006457 protein folding; IEA:UniProtKB-HAMAP. # GO_process GO:0051604 protein maturation; IEP:EcoliWiki. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006457 protein folding # GOslim_process GO:0051604 protein maturation # Gene3D 1.10.3480.10 -; 1. # HAMAP MF_01150 TorD # INTERACTION TORD_ECOLI Self; NbExp=4; IntAct=EBI-6406226, EBI-6406226; P33225 torA; NbExp=24; IntAct=EBI-6406226, EBI-557008; # IntAct P36662 4 # InterPro IPR020945 DMSO/NO3_reduct_chaperone # InterPro IPR023069 Chaperone_TorD # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02020 Two-component system # Organism TORD_ECOLI Escherichia coli (strain K12) # PATRIC 32117221 VBIEscCol129921_1034 # PIR D64841 D64841 # Pfam PF02613 Nitrate_red_del # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TORD_ECOLI Chaperone protein TorD # RefSeq NP_415518 NC_000913.3 # RefSeq WP_000209861 NZ_LN832404.1 # RefSeq WP_000209894 NZ_CP010440.1 # SIMILARITY Belongs to the TorD/DmsD family. TorD subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION TORD_ECOLI Cytoplasm {ECO 0000269|PubMed 9632735}. # SUPFAM SSF89155 SSF89155 # TCDB 5.A.3.4 the prokaryotic molybdopterin-containing oxidoreductase (pmo) family # eggNOG COG3381 LUCA # eggNOG ENOG4108SBI Bacteria BLAST swissprot:TORD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TORD_ECOLI BioCyc ECOL316407:JW0983-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0983-MONOMER BioCyc EcoCyc:EG12195-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12195-MONOMER COG COG3381 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3381 DIP DIP-11015N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11015N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.91.3.1054 http://dx.doi.org/10.1073/pnas.91.3.1054 DOI 10.1074/jbc.273.26.16615 http://dx.doi.org/10.1074/jbc.273.26.16615 DOI 10.1074/jbc.M302730200 http://dx.doi.org/10.1074/jbc.M302730200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1994.tb00393.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb00393.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D16500 http://www.ebi.ac.uk/ena/data/view/D16500 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X73888 http://www.ebi.ac.uk/ena/data/view/X73888 EchoBASE EB2112 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2112 EcoGene EG12195 http://www.ecogene.org/geneInfo.php?eg_id=EG12195 EnsemblBacteria AAC74083 http://www.ensemblgenomes.org/id/AAC74083 EnsemblBacteria AAC74083 http://www.ensemblgenomes.org/id/AAC74083 EnsemblBacteria BAA36140 http://www.ensemblgenomes.org/id/BAA36140 EnsemblBacteria BAA36140 http://www.ensemblgenomes.org/id/BAA36140 EnsemblBacteria BAA36140 http://www.ensemblgenomes.org/id/BAA36140 EnsemblBacteria b0998 http://www.ensemblgenomes.org/id/b0998 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0042277 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042277 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0043546 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043546 GO_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GO_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GOslim_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 Gene3D 1.10.3480.10 http://www.cathdb.info/version/latest/superfamily/1.10.3480.10 GeneID 945625 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945625 HAMAP MF_01150 http://hamap.expasy.org/unirule/MF_01150 HOGENOM HOG000281891 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000281891&db=HOGENOM6 InParanoid P36662 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P36662 IntAct P36662 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P36662* InterPro IPR020945 http://www.ebi.ac.uk/interpro/entry/IPR020945 InterPro IPR023069 http://www.ebi.ac.uk/interpro/entry/IPR023069 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0983 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0983 KEGG_Gene eco:b0998 http://www.genome.jp/dbget-bin/www_bget?eco:b0998 KEGG_Orthology KO:K03533 http://www.genome.jp/dbget-bin/www_bget?KO:K03533 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 MINT MINT-6796213 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-6796213 OMA ILAYVAH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ILAYVAH PSORT swissprot:TORD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TORD_ECOLI PSORT-B swissprot:TORD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TORD_ECOLI PSORT2 swissprot:TORD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TORD_ECOLI Pfam PF02613 http://pfam.xfam.org/family/PF02613 Phobius swissprot:TORD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TORD_ECOLI ProteinModelPortal P36662 http://www.proteinmodelportal.org/query/uniprot/P36662 PubMed 12766163 http://www.ncbi.nlm.nih.gov/pubmed/12766163 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8022286 http://www.ncbi.nlm.nih.gov/pubmed/8022286 PubMed 8302830 http://www.ncbi.nlm.nih.gov/pubmed/8302830 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9632735 http://www.ncbi.nlm.nih.gov/pubmed/9632735 RefSeq NP_415518 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415518 RefSeq WP_000209861 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000209861 RefSeq WP_000209894 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000209894 SMR P36662 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P36662 STRING 511145.b0998 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0998&targetmode=cogs STRING COG3381 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3381&targetmode=cogs SUPFAM SSF89155 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF89155 TCDB 5.A.3.4 http://www.tcdb.org/search/result.php?tc=5.A.3.4 UniProtKB TORD_ECOLI http://www.uniprot.org/uniprot/TORD_ECOLI UniProtKB-AC P36662 http://www.uniprot.org/uniprot/P36662 charge swissprot:TORD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TORD_ECOLI eggNOG COG3381 http://eggnogapi.embl.de/nog_data/html/tree/COG3381 eggNOG ENOG4108SBI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108SBI epestfind swissprot:TORD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TORD_ECOLI garnier swissprot:TORD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TORD_ECOLI helixturnhelix swissprot:TORD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TORD_ECOLI hmoment swissprot:TORD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TORD_ECOLI iep swissprot:TORD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TORD_ECOLI inforesidue swissprot:TORD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TORD_ECOLI octanol swissprot:TORD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TORD_ECOLI pepcoil swissprot:TORD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TORD_ECOLI pepdigest swissprot:TORD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TORD_ECOLI pepinfo swissprot:TORD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TORD_ECOLI pepnet swissprot:TORD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TORD_ECOLI pepstats swissprot:TORD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TORD_ECOLI pepwheel swissprot:TORD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TORD_ECOLI pepwindow swissprot:TORD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TORD_ECOLI sigcleave swissprot:TORD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TORD_ECOLI ## Database ID URL or Descriptions # AltName TNAA_ECOLI L-tryptophan indole-lyase # BRENDA 4.1.99 2026 # BioGrid 4262594 8 # CATALYTIC ACTIVITY TNAA_ECOLI L-tryptophan + H(2)O = indole + pyruvate + NH(3). # COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI 597326; # DISRUPTION PHENOTYPE Not essential, cells do not produce indole. {ECO:0000269|PubMed 22380631}. # EcoGene EG11005 tnaA # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_component GO:0060187 cell pole; IDA:EcoCyc. # GO_function GO:0009034 tryptophanase activity; IDA:EcoCyc. # GO_function GO:0030170 pyridoxal phosphate binding; IDA:EcoCyc. # GO_function GO:0030955 potassium ion binding; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0080146 L-cysteine desulfhydrase activity; IMP:EcoCyc. # GO_process GO:0006520 cellular amino acid metabolic process; IEA:InterPro. # GO_process GO:0006569 tryptophan catabolic process; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.640.10 -; 1. # Gene3D 3.90.1150.10 -; 1. # HAMAP MF_00544 Tryptophanase # INDUCTION Repressed by cold shock. {ECO:0000269|PubMed 14527658}. # INTERACTION TNAA_ECOLI Self; NbExp=2; IntAct=EBI-371316, EBI-371316; # IntAct P0A853 12 # InterPro IPR001597 ArAA_b-elim_lyase/Thr_aldolase # InterPro IPR011166 Beta-eliminating_lyase # InterPro IPR013440 TNase # InterPro IPR015421 PyrdxlP-dep_Trfase_major_sub1 # InterPro IPR015422 PyrdxlP-dep_Trfase_major_sub2 # InterPro IPR015424 PyrdxlP-dep_Trfase # InterPro IPR018176 Tryptophanase_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00380 Tryptophan metabolism # Organism TNAA_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid degradation; L-tryptophan degradation via pyruvate pathway; indole and pyruvate from L-tryptophan step 1/1. # PATRIC 32122911 VBIEscCol129921_3831 # PDB 2C44 X-ray; 2.81 A; A/B/C/D=1-471 # PDB 2OQX X-ray; 1.90 A; A=5-471 # PDB 2V0Y X-ray; 2.00 A; A=5-471 # PDB 2V1P X-ray; 1.90 A; A=5-471 # PDB 4UP2 X-ray; 2.78 A; A/B/C/D=1-471 # PDB 4W1Y X-ray; 3.20 A; A/B=5-471 # PDB 4W4H X-ray; 2.89 A; A/B=5-471 # PDB 5D8G X-ray; 1.89 A; A=5-471 # PIR E65173 WZEC # PIRSF PIRSF001386 Trpase # PROSITE PS00853 BETA_ELIM_LYASE # Pfam PF01212 Beta_elim_lyase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TNAA_ECOLI Tryptophanase # RefSeq NP_418164 NC_000913.3 # RefSeq WP_001295247 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA62059.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the beta-eliminating lyase family. {ECO 0000305}. # SUBCELLULAR LOCATION TNAA_ECOLI Cytoplasm {ECO 0000305|PubMed 22380631}. Note=Almost exclusively localized in foci near 1 cell pole in mid- to-late exponential phase, fewer cells have foci at stationary phase; polar localization depends on the minCDE operon. # SUBUNIT Homotetramer. {ECO:0000269|PubMed 16790938}. # SUPFAM SSF53383 SSF53383 # TIGRFAMs TIGR02617 tnaA_trp_ase # UniPathway UPA00332 UER00452 # eggNOG COG3033 LUCA # eggNOG ENOG4105C0F Bacteria BLAST swissprot:TNAA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TNAA_ECOLI BioCyc ECOL316407:JW3686-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3686-MONOMER BioCyc EcoCyc:TRYPTOPHAN-MONOMER http://biocyc.org/getid?id=EcoCyc:TRYPTOPHAN-MONOMER BioCyc MetaCyc:TRYPTOPHAN-MONOMER http://biocyc.org/getid?id=MetaCyc:TRYPTOPHAN-MONOMER COG COG3033 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3033 DIP DIP-31878N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31878N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1016/0300-9084(89)90087-4 http://dx.doi.org/10.1016/0300-9084(89)90087-4 DOI 10.1016/S0923-2508(03)00167-0 http://dx.doi.org/10.1016/S0923-2508(03)00167-0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1107/S0907444906019895 http://dx.doi.org/10.1107/S0907444906019895 DOI 10.1111/j.1365-2958.2012.08021.x http://dx.doi.org/10.1111/j.1365-2958.2012.08021.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1266/ggs.82.291 http://dx.doi.org/10.1266/ggs.82.291 EC_number EC:4.1.99.1 http://www.genome.jp/dbget-bin/www_bget?EC:4.1.99.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K00032 http://www.ebi.ac.uk/ena/data/view/K00032 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M11990 http://www.ebi.ac.uk/ena/data/view/M11990 EMBL M59914 http://www.ebi.ac.uk/ena/data/view/M59914 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X15974 http://www.ebi.ac.uk/ena/data/view/X15974 ENZYME 4.1.99.1 http://enzyme.expasy.org/EC/4.1.99.1 EchoBASE EB0998 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0998 EcoGene EG11005 http://www.ecogene.org/geneInfo.php?eg_id=EG11005 EnsemblBacteria AAC76731 http://www.ensemblgenomes.org/id/AAC76731 EnsemblBacteria AAC76731 http://www.ensemblgenomes.org/id/AAC76731 EnsemblBacteria BAE77584 http://www.ensemblgenomes.org/id/BAE77584 EnsemblBacteria BAE77584 http://www.ensemblgenomes.org/id/BAE77584 EnsemblBacteria BAE77584 http://www.ensemblgenomes.org/id/BAE77584 EnsemblBacteria b3708 http://www.ensemblgenomes.org/id/b3708 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0060187 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060187 GO_function GO:0009034 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009034 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_function GO:0030955 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030955 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0080146 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0080146 GO_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GO_process GO:0006569 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006569 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.640.10 http://www.cathdb.info/version/latest/superfamily/3.40.640.10 Gene3D 3.90.1150.10 http://www.cathdb.info/version/latest/superfamily/3.90.1150.10 GeneID 948221 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948221 HAMAP MF_00544 http://hamap.expasy.org/unirule/MF_00544 HOGENOM HOG000057883 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000057883&db=HOGENOM6 InParanoid P0A853 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A853 IntAct P0A853 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A853* IntEnz 4.1.99.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.99.1 InterPro IPR001597 http://www.ebi.ac.uk/interpro/entry/IPR001597 InterPro IPR011166 http://www.ebi.ac.uk/interpro/entry/IPR011166 InterPro IPR013440 http://www.ebi.ac.uk/interpro/entry/IPR013440 InterPro IPR015421 http://www.ebi.ac.uk/interpro/entry/IPR015421 InterPro IPR015422 http://www.ebi.ac.uk/interpro/entry/IPR015422 InterPro IPR015424 http://www.ebi.ac.uk/interpro/entry/IPR015424 InterPro IPR018176 http://www.ebi.ac.uk/interpro/entry/IPR018176 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3686 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3686 KEGG_Gene eco:b3708 http://www.genome.jp/dbget-bin/www_bget?eco:b3708 KEGG_Orthology KO:K01667 http://www.genome.jp/dbget-bin/www_bget?KO:K01667 KEGG_Pathway ko00380 http://www.genome.jp/kegg-bin/show_pathway?ko00380 KEGG_Reaction rn:R00673 http://www.genome.jp/dbget-bin/www_bget?rn:R00673 MINT MINT-1267429 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1267429 OMA IDACRFA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IDACRFA PDB 2C44 http://www.ebi.ac.uk/pdbe-srv/view/entry/2C44 PDB 2OQX http://www.ebi.ac.uk/pdbe-srv/view/entry/2OQX PDB 2V0Y http://www.ebi.ac.uk/pdbe-srv/view/entry/2V0Y PDB 2V1P http://www.ebi.ac.uk/pdbe-srv/view/entry/2V1P PDB 4UP2 http://www.ebi.ac.uk/pdbe-srv/view/entry/4UP2 PDB 4W1Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4W1Y PDB 4W4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4W4H PDB 5D8G http://www.ebi.ac.uk/pdbe-srv/view/entry/5D8G PDBsum 2C44 http://www.ebi.ac.uk/pdbsum/2C44 PDBsum 2OQX http://www.ebi.ac.uk/pdbsum/2OQX PDBsum 2V0Y http://www.ebi.ac.uk/pdbsum/2V0Y PDBsum 2V1P http://www.ebi.ac.uk/pdbsum/2V1P PDBsum 4UP2 http://www.ebi.ac.uk/pdbsum/4UP2 PDBsum 4W1Y http://www.ebi.ac.uk/pdbsum/4W1Y PDBsum 4W4H http://www.ebi.ac.uk/pdbsum/4W4H PDBsum 5D8G http://www.ebi.ac.uk/pdbsum/5D8G PROSITE PS00853 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00853 PSORT swissprot:TNAA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TNAA_ECOLI PSORT-B swissprot:TNAA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TNAA_ECOLI PSORT2 swissprot:TNAA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TNAA_ECOLI Pfam PF01212 http://pfam.xfam.org/family/PF01212 Phobius swissprot:TNAA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TNAA_ECOLI PhylomeDB P0A853 http://phylomedb.org/?seqid=P0A853 ProteinModelPortal P0A853 http://www.proteinmodelportal.org/query/uniprot/P0A853 PubMed 14527658 http://www.ncbi.nlm.nih.gov/pubmed/14527658 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16790938 http://www.ncbi.nlm.nih.gov/pubmed/16790938 PubMed 17895580 http://www.ncbi.nlm.nih.gov/pubmed/17895580 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 2022620 http://www.ncbi.nlm.nih.gov/pubmed/2022620 PubMed 22380631 http://www.ncbi.nlm.nih.gov/pubmed/22380631 PubMed 2502187 http://www.ncbi.nlm.nih.gov/pubmed/2502187 PubMed 2659590 http://www.ncbi.nlm.nih.gov/pubmed/2659590 PubMed 3902796 http://www.ncbi.nlm.nih.gov/pubmed/3902796 PubMed 4551944 http://www.ncbi.nlm.nih.gov/pubmed/4551944 PubMed 6268608 http://www.ncbi.nlm.nih.gov/pubmed/6268608 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_418164 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418164 RefSeq WP_001295247 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295247 SMR P0A853 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A853 STRING 511145.b3708 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3708&targetmode=cogs STRING COG3033 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3033&targetmode=cogs SUPFAM SSF53383 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53383 SWISS-2DPAGE P0A853 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A853 TIGRFAMs TIGR02617 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02617 UniProtKB TNAA_ECOLI http://www.uniprot.org/uniprot/TNAA_ECOLI UniProtKB-AC P0A853 http://www.uniprot.org/uniprot/P0A853 charge swissprot:TNAA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TNAA_ECOLI eggNOG COG3033 http://eggnogapi.embl.de/nog_data/html/tree/COG3033 eggNOG ENOG4105C0F http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C0F epestfind swissprot:TNAA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TNAA_ECOLI garnier swissprot:TNAA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TNAA_ECOLI helixturnhelix swissprot:TNAA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TNAA_ECOLI hmoment swissprot:TNAA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TNAA_ECOLI iep swissprot:TNAA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TNAA_ECOLI inforesidue swissprot:TNAA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TNAA_ECOLI octanol swissprot:TNAA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TNAA_ECOLI pepcoil swissprot:TNAA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TNAA_ECOLI pepdigest swissprot:TNAA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TNAA_ECOLI pepinfo swissprot:TNAA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TNAA_ECOLI pepnet swissprot:TNAA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TNAA_ECOLI pepstats swissprot:TNAA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TNAA_ECOLI pepwheel swissprot:TNAA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TNAA_ECOLI pepwindow swissprot:TNAA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TNAA_ECOLI sigcleave swissprot:TNAA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TNAA_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES YBJI_ECOLI Kinetic parameters KM=70 uM for 5-amino-6-(5-phospho-D-ribitylamino)uracil {ECO 0000269|PubMed 24123841}; KM=2.3 mM for FMN (in the presence of magnesium ion as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; KM=2.6 mM for Ery4P (in the presence of magnesium ion as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; Vmax=3 umol/min/mg enzyme with 5-amino-6-(5-phospho-D- ribitylamino)uracil as substrate {ECO 0000269|PubMed 24123841}; pH dependence Optimum pH is 6-7.5. {ECO 0000269|PubMed 16990279}; # BioGrid 4262830 120 # CATALYTIC ACTIVITY 5-amino-6-(5-phospho-D-ribitylamino)uracil + H(2)O = 5-amino-6-(D-ribitylamino)uracil + phosphate. {ECO:0000269|PubMed 24123841}. # COFACTOR YBJI_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 16990279}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 16990279}; Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000269|PubMed 16990279}; Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 16990279}; Note=Magnesium. Can also use other divalent metal cations as manganese, cobalt or zinc. {ECO 0000269|PubMed 16990279}; # DISRUPTION PHENOTYPE Cells lacking this gene can grow in the absence of exogenous riboflavin; this may be due to the presence of the functionally redundant protein YigB. {ECO:0000269|PubMed 24123841}. # EcoGene EG13678 ybjI # FUNCTION YBJI_ECOLI Catalyzes the dephosphorylation of 5-amino-6-(5-phospho- D-ribitylamino)uracil, and thus could be involved in the riboflavin biosynthesis pathway (PubMed 24123841). Is also able to dephosphorylate flavin mononucleotide (FMN), erythrose 4-phosphate and other phosphoric acid esters (PubMed 15808744, PubMed 16990279, PubMed 24123841). {ECO 0000269|PubMed 15808744, ECO 0000269|PubMed 16990279, ECO 0000269|PubMed 24123841}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0000287 magnesium ion binding; IDA:UniProtKB. # GO_function GO:0016791 phosphatase activity; IDA:UniProtKB. # GO_function GO:0043726 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity; IDA:EcoCyc. # GO_process GO:0009231 riboflavin biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.1000 -; 2. # InterPro IPR000150 Hypothet_cof # InterPro IPR006379 HAD-SF_hydro_IIB # InterPro IPR023214 HAD-like_dom # Organism YBJI_ECOLI Escherichia coli (strain K12) # PATHWAY Cofactor biosynthesis; riboflavin biosynthesis; 5-amino- 6-(D-ribitylamino)uracil from GTP: step 4/4. {ECO 0000305|PubMed:24123841}. # PATRIC 32116893 VBIEscCol129921_0872 # PIR D64822 D64822 # PROSITE PS01229 COF_2 # Pfam PF08282 Hydrolase_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase YbjI {ECO:0000303|PubMed 24123841} # RefSeq NP_415365 NC_000913.3 # RefSeq WP_000023565 NZ_LN832404.1 # SIMILARITY Belongs to the HAD-like hydrolase superfamily. Cof family. {ECO 0000305}. # SUPFAM SSF56784 SSF56784 # TIGRFAMs TIGR00099 Cof-subfamily # TIGRFAMs TIGR01484 HAD-SF-IIB # UniPathway UPA00275 UER00403 # eggNOG COG0561 LUCA # eggNOG ENOG4108HCJ Bacteria BLAST swissprot:YBJI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBJI_ECOLI BioCyc ECOL316407:JW5113-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5113-MONOMER BioCyc EcoCyc:G6442-MONOMER http://biocyc.org/getid?id=EcoCyc:G6442-MONOMER BioCyc MetaCyc:G6442-MONOMER http://biocyc.org/getid?id=MetaCyc:G6442-MONOMER COG COG0561 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0561 DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1002/cbic.201300544 http://dx.doi.org/10.1002/cbic.201300544 DOI 10.1016/j.fmrre.2004.12.006 http://dx.doi.org/10.1016/j.fmrre.2004.12.006 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M605449200 http://dx.doi.org/10.1074/jbc.M605449200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.3.- {ECO:0000269|PubMed:24123841} http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.- {ECO:0000269|PubMed:24123841} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.3.- {ECO:0000269|PubMed:24123841} http://enzyme.expasy.org/EC/3.1.3.- {ECO:0000269|PubMed:24123841} EchoBASE EB3442 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3442 EcoGene EG13678 http://www.ecogene.org/geneInfo.php?eg_id=EG13678 EnsemblBacteria AAC73931 http://www.ensemblgenomes.org/id/AAC73931 EnsemblBacteria AAC73931 http://www.ensemblgenomes.org/id/AAC73931 EnsemblBacteria BAA35548 http://www.ensemblgenomes.org/id/BAA35548 EnsemblBacteria BAA35548 http://www.ensemblgenomes.org/id/BAA35548 EnsemblBacteria BAA35548 http://www.ensemblgenomes.org/id/BAA35548 EnsemblBacteria b0844 http://www.ensemblgenomes.org/id/b0844 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GO_function GO:0043726 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043726 GO_process GO:0009231 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009231 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.1000 http://www.cathdb.info/version/latest/superfamily/3.40.50.1000 GeneID 945470 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945470 HOGENOM HOG000184782 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000184782&db=HOGENOM6 InParanoid P75809 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75809 IntEnz 3.1.3.- {ECO:0000269|PubMed:24123841} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.- {ECO:0000269|PubMed:24123841} InterPro IPR000150 http://www.ebi.ac.uk/interpro/entry/IPR000150 InterPro IPR006379 http://www.ebi.ac.uk/interpro/entry/IPR006379 InterPro IPR023214 http://www.ebi.ac.uk/interpro/entry/IPR023214 KEGG_Gene ecj:JW5113 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5113 KEGG_Gene eco:b0844 http://www.genome.jp/dbget-bin/www_bget?eco:b0844 KEGG_Orthology KO:K07024 http://www.genome.jp/dbget-bin/www_bget?KO:K07024 OMA LNDIFFK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LNDIFFK PROSITE PS01229 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01229 PSORT swissprot:YBJI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBJI_ECOLI PSORT-B swissprot:YBJI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBJI_ECOLI PSORT2 swissprot:YBJI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBJI_ECOLI Pfam PF08282 http://pfam.xfam.org/family/PF08282 Phobius swissprot:YBJI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBJI_ECOLI PhylomeDB P75809 http://phylomedb.org/?seqid=P75809 ProteinModelPortal P75809 http://www.proteinmodelportal.org/query/uniprot/P75809 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 15808744 http://www.ncbi.nlm.nih.gov/pubmed/15808744 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16990279 http://www.ncbi.nlm.nih.gov/pubmed/16990279 PubMed 24123841 http://www.ncbi.nlm.nih.gov/pubmed/24123841 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415365 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415365 RefSeq WP_000023565 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000023565 SMR P75809 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75809 STRING 511145.b0844 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0844&targetmode=cogs STRING COG0561 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0561&targetmode=cogs SUPFAM SSF56784 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784 TIGRFAMs TIGR00099 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00099 TIGRFAMs TIGR01484 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01484 UniProtKB YBJI_ECOLI http://www.uniprot.org/uniprot/YBJI_ECOLI UniProtKB-AC P75809 http://www.uniprot.org/uniprot/P75809 charge swissprot:YBJI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBJI_ECOLI eggNOG COG0561 http://eggnogapi.embl.de/nog_data/html/tree/COG0561 eggNOG ENOG4108HCJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108HCJ epestfind swissprot:YBJI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBJI_ECOLI garnier swissprot:YBJI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBJI_ECOLI helixturnhelix swissprot:YBJI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBJI_ECOLI hmoment swissprot:YBJI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBJI_ECOLI iep swissprot:YBJI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBJI_ECOLI inforesidue swissprot:YBJI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBJI_ECOLI octanol swissprot:YBJI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBJI_ECOLI pepcoil swissprot:YBJI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBJI_ECOLI pepdigest swissprot:YBJI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBJI_ECOLI pepinfo swissprot:YBJI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBJI_ECOLI pepnet swissprot:YBJI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBJI_ECOLI pepstats swissprot:YBJI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBJI_ECOLI pepwheel swissprot:YBJI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBJI_ECOLI pepwindow swissprot:YBJI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBJI_ECOLI sigcleave swissprot:YBJI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBJI_ECOLI ## Database ID URL or Descriptions # AltName DNA topoisomerase I {ECO:0000255|HAMAP-Rule MF_00952} # AltName TOP1_ECOLI Omega-protein # AltName TOP1_ECOLI Relaxing enzyme # AltName TOP1_ECOLI Swivelase # AltName TOP1_ECOLI Untwisting enzyme # BRENDA 5.99.1 2026 # BioGrid 4259579 139 # CATALYTIC ACTIVITY TOP1_ECOLI ATP-independent breakage of single-stranded DNA, followed by passage and rejoining. {ECO 0000255|HAMAP- Rule MF_00952, ECO 0000269|PubMed 10681504, ECO 0000269|PubMed 14604525, ECO 0000269|PubMed 21482796, ECO 0000269|PubMed 9497321}. # CDD cd00186 TOP1Ac # COFACTOR TOP1_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 10681504, ECO 0000269|PubMed 21482796}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 10681504, ECO 0000269|PubMed 21482796}; Name=Ca(2+); Xref=ChEBI CHEBI 29108; Evidence={ECO 0000269|PubMed 10681504, ECO 0000269|PubMed 21482796}; Note=Binds two Mg(2+) ions per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+). {ECO 0000269|PubMed 10681504, ECO 0000269|PubMed 21482796}; # EcoGene EG11013 topA # FUNCTION TOP1_ECOLI Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. {ECO 0000255|HAMAP- Rule MF_00952, ECO 0000269|PubMed 10681504, ECO 0000269|PubMed 21482796, ECO 0000269|PubMed 9497321}. # GO_component GO:0005694 chromosome; IEA:InterPro. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003916 DNA topoisomerase activity; IMP:EcoCyc. # GO_function GO:0003917 DNA topoisomerase type I activity; IMP:EcoCyc. # GO_process GO:0006265 DNA topological change; IGI:EcoliWiki. # GOslim_component GO:0005694 chromosome # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0051276 chromosome organization # Gene3D 1.10.460.10 -; 3. # Gene3D 2.70.20.10 -; 2. # Gene3D 3.40.50.140 -; 1. # HAMAP MF_00952 Topoisom_1_prok # IntAct P06612 68 # InterPro IPR000380 Topo_IA # InterPro IPR003601 Topo_IA_2 # InterPro IPR003602 Topo_IA_DNA-bd_dom # InterPro IPR005733 TopoI_bac-type # InterPro IPR006171 Toprim_domain # InterPro IPR013263 TopoI_Znr_bac # InterPro IPR013497 Topo_IA_cen # InterPro IPR013498 Topo_IA_Znf # InterPro IPR013824 Topo_IA_cen_sub1 # InterPro IPR013825 Topo_IA_cen_sub2 # InterPro IPR023405 Topo_IA_core_domain # InterPro IPR023406 Topo_IA_AS # InterPro IPR028612 Topoisom_1_IA # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03032 DNA replication proteins # KEGG_Brite ko03400 DNA repair and recombination proteins # Organism TOP1_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11390 PTHR11390; 2 # PATRIC 32117806 VBIEscCol129921_1323 # PDB 1CY0 X-ray; 2.45 A; A=1-597 # PDB 1CY1 X-ray; 2.30 A; A=1-597 # PDB 1CY2 X-ray; 2.30 A; A=1-597 # PDB 1CY4 X-ray; 2.55 A; A=1-597 # PDB 1CY6 X-ray; 2.50 A; A=1-597 # PDB 1CY7 X-ray; 2.40 A; A=1-597 # PDB 1CY8 X-ray; 2.45 A; A=1-597 # PDB 1CY9 X-ray; 1.80 A; A/B=214-477 # PDB 1CYY X-ray; 2.15 A; A/B=214-477 # PDB 1ECL X-ray; 1.90 A; A=1-597 # PDB 1MW8 X-ray; 1.90 A; X=1-592 # PDB 1MW9 X-ray; 1.67 A; X=1-592 # PDB 1YUA NMR; -; A=745-865 # PDB 3PWT X-ray; 1.90 A; A=1-596 # PDB 3PX7 X-ray; 2.30 A; A=1-595 # PDB 4RUL X-ray; 2.90 A; A=2-865 # PIR E64875 ISECTP # PRINTS PR00417 PRTPISMRASEI # PROSITE PS00396 TOPOISOMERASE_I_PROK # PROSITE PS50880 TOPRIM # Pfam PF01131 Topoisom_bac # Pfam PF01396 zf-C4_Topoisom; 2 # Pfam PF01751 Toprim # Pfam PF08272 Topo_Zn_Ribbon; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DNA topoisomerase 1 {ECO:0000255|HAMAP-Rule MF_00952} # RefSeq NP_415790 NC_000913.3 # RefSeq WP_001297122 NZ_CP014272.1 # SIMILARITY Belongs to the type IA topoisomerase family. {ECO:0000255|HAMAP-Rule MF_00952}. # SIMILARITY Contains 1 Toprim domain. {ECO:0000255|HAMAP- Rule MF_00952}. # SMART SM00436 TOP1Bc # SMART SM00437 TOP1Ac # SMART SM00493 TOPRIM # SUBUNIT TOP1_ECOLI Monomer. {ECO 0000255|HAMAP-Rule MF_00952, ECO 0000269|PubMed 14604525, ECO 0000269|PubMed 21482796}. # SUPFAM SSF56712 SSF56712 # TIGRFAMs TIGR01051 topA_bact # eggNOG COG0550 LUCA # eggNOG COG0551 LUCA # eggNOG ENOG4105C73 Bacteria BLAST swissprot:TOP1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TOP1_ECOLI BioCyc ECOL316407:JW1266-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1266-MONOMER BioCyc EcoCyc:EG11013-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11013-MONOMER BioCyc MetaCyc:EG11013-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11013-MONOMER COG COG0550 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0550 COG COG0551 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0551 COG COG1754 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1754 DIP DIP-11011N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11011N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0022-2836(86)90129-4 http://dx.doi.org/10.1016/0022-2836(86)90129-4 DOI 10.1016/j.str.2003.09.013 http://dx.doi.org/10.1016/j.str.2003.09.013 DOI 10.1021/bi00023a008 http://dx.doi.org/10.1021/bi00023a008 DOI 10.1038/13283 http://dx.doi.org/10.1038/13283 DOI 10.1038/13333 http://dx.doi.org/10.1038/13333 DOI 10.1038/367138a0 http://dx.doi.org/10.1038/367138a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.1100300108 http://dx.doi.org/10.1073/pnas.1100300108 DOI 10.1074/jbc.273.11.6050 http://dx.doi.org/10.1074/jbc.273.11.6050 DOI 10.1074/jbc.275.8.5318 http://dx.doi.org/10.1074/jbc.275.8.5318 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.99.1.2 {ECO:0000255|HAMAP-Rule:MF_00952} http://www.genome.jp/dbget-bin/www_bget?EC:5.99.1.2 {ECO:0000255|HAMAP-Rule:MF_00952} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M15041 http://www.ebi.ac.uk/ena/data/view/M15041 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X04475 http://www.ebi.ac.uk/ena/data/view/X04475 ENZYME 5.99.1.2 {ECO:0000255|HAMAP-Rule:MF_00952} http://enzyme.expasy.org/EC/5.99.1.2 {ECO:0000255|HAMAP-Rule:MF_00952} EchoBASE EB1006 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1006 EcoGene EG11013 http://www.ecogene.org/geneInfo.php?eg_id=EG11013 EnsemblBacteria AAC74356 http://www.ensemblgenomes.org/id/AAC74356 EnsemblBacteria AAC74356 http://www.ensemblgenomes.org/id/AAC74356 EnsemblBacteria BAA14811 http://www.ensemblgenomes.org/id/BAA14811 EnsemblBacteria BAA14811 http://www.ensemblgenomes.org/id/BAA14811 EnsemblBacteria BAA14811 http://www.ensemblgenomes.org/id/BAA14811 EnsemblBacteria b1274 http://www.ensemblgenomes.org/id/b1274 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005694 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005694 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003916 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003916 GO_function GO:0003917 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003917 GO_process GO:0006265 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006265 GOslim_component GO:0005694 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005694 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0051276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051276 Gene3D 1.10.460.10 http://www.cathdb.info/version/latest/superfamily/1.10.460.10 Gene3D 2.70.20.10 http://www.cathdb.info/version/latest/superfamily/2.70.20.10 Gene3D 3.40.50.140 http://www.cathdb.info/version/latest/superfamily/3.40.50.140 GeneID 945862 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945862 HAMAP MF_00952 http://hamap.expasy.org/unirule/MF_00952 HOGENOM HOG000004018 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000004018&db=HOGENOM6 InParanoid P06612 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P06612 IntAct P06612 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P06612* IntEnz 5.99.1.2 {ECO:0000255|HAMAP-Rule:MF_00952} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.99.1.2 {ECO:0000255|HAMAP-Rule:MF_00952} InterPro IPR000380 http://www.ebi.ac.uk/interpro/entry/IPR000380 InterPro IPR003601 http://www.ebi.ac.uk/interpro/entry/IPR003601 InterPro IPR003602 http://www.ebi.ac.uk/interpro/entry/IPR003602 InterPro IPR005733 http://www.ebi.ac.uk/interpro/entry/IPR005733 InterPro IPR006171 http://www.ebi.ac.uk/interpro/entry/IPR006171 InterPro IPR013263 http://www.ebi.ac.uk/interpro/entry/IPR013263 InterPro IPR013497 http://www.ebi.ac.uk/interpro/entry/IPR013497 InterPro IPR013498 http://www.ebi.ac.uk/interpro/entry/IPR013498 InterPro IPR013824 http://www.ebi.ac.uk/interpro/entry/IPR013824 InterPro IPR013825 http://www.ebi.ac.uk/interpro/entry/IPR013825 InterPro IPR023405 http://www.ebi.ac.uk/interpro/entry/IPR023405 InterPro IPR023406 http://www.ebi.ac.uk/interpro/entry/IPR023406 InterPro IPR028612 http://www.ebi.ac.uk/interpro/entry/IPR028612 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03032 http://www.genome.jp/dbget-bin/www_bget?ko03032 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW1266 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1266 KEGG_Gene eco:b1274 http://www.genome.jp/dbget-bin/www_bget?eco:b1274 KEGG_Orthology KO:K03168 http://www.genome.jp/dbget-bin/www_bget?KO:K03168 MINT MINT-1218330 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1218330 OMA VVECDKC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VVECDKC PANTHER PTHR11390 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11390 PDB 1CY0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1CY0 PDB 1CY1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1CY1 PDB 1CY2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1CY2 PDB 1CY4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1CY4 PDB 1CY6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1CY6 PDB 1CY7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1CY7 PDB 1CY8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1CY8 PDB 1CY9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1CY9 PDB 1CYY http://www.ebi.ac.uk/pdbe-srv/view/entry/1CYY PDB 1ECL http://www.ebi.ac.uk/pdbe-srv/view/entry/1ECL PDB 1MW8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1MW8 PDB 1MW9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1MW9 PDB 1YUA http://www.ebi.ac.uk/pdbe-srv/view/entry/1YUA PDB 3PWT http://www.ebi.ac.uk/pdbe-srv/view/entry/3PWT PDB 3PX7 http://www.ebi.ac.uk/pdbe-srv/view/entry/3PX7 PDB 4RUL http://www.ebi.ac.uk/pdbe-srv/view/entry/4RUL PDBsum 1CY0 http://www.ebi.ac.uk/pdbsum/1CY0 PDBsum 1CY1 http://www.ebi.ac.uk/pdbsum/1CY1 PDBsum 1CY2 http://www.ebi.ac.uk/pdbsum/1CY2 PDBsum 1CY4 http://www.ebi.ac.uk/pdbsum/1CY4 PDBsum 1CY6 http://www.ebi.ac.uk/pdbsum/1CY6 PDBsum 1CY7 http://www.ebi.ac.uk/pdbsum/1CY7 PDBsum 1CY8 http://www.ebi.ac.uk/pdbsum/1CY8 PDBsum 1CY9 http://www.ebi.ac.uk/pdbsum/1CY9 PDBsum 1CYY http://www.ebi.ac.uk/pdbsum/1CYY PDBsum 1ECL http://www.ebi.ac.uk/pdbsum/1ECL PDBsum 1MW8 http://www.ebi.ac.uk/pdbsum/1MW8 PDBsum 1MW9 http://www.ebi.ac.uk/pdbsum/1MW9 PDBsum 1YUA http://www.ebi.ac.uk/pdbsum/1YUA PDBsum 3PWT http://www.ebi.ac.uk/pdbsum/3PWT PDBsum 3PX7 http://www.ebi.ac.uk/pdbsum/3PX7 PDBsum 4RUL http://www.ebi.ac.uk/pdbsum/4RUL PRINTS PR00417 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00417 PROSITE PS00396 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00396 PROSITE PS50880 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50880 PSORT swissprot:TOP1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TOP1_ECOLI PSORT-B swissprot:TOP1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TOP1_ECOLI PSORT2 swissprot:TOP1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TOP1_ECOLI Pfam PF01131 http://pfam.xfam.org/family/PF01131 Pfam PF01396 http://pfam.xfam.org/family/PF01396 Pfam PF01751 http://pfam.xfam.org/family/PF01751 Pfam PF08272 http://pfam.xfam.org/family/PF08272 Phobius swissprot:TOP1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TOP1_ECOLI PhylomeDB P06612 http://phylomedb.org/?seqid=P06612 ProteinModelPortal P06612 http://www.proteinmodelportal.org/query/uniprot/P06612 PubMed 10504724 http://www.ncbi.nlm.nih.gov/pubmed/10504724 PubMed 10504732 http://www.ncbi.nlm.nih.gov/pubmed/10504732 PubMed 10681504 http://www.ncbi.nlm.nih.gov/pubmed/10681504 PubMed 14604525 http://www.ncbi.nlm.nih.gov/pubmed/14604525 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21482796 http://www.ncbi.nlm.nih.gov/pubmed/21482796 PubMed 3029379 http://www.ncbi.nlm.nih.gov/pubmed/3029379 PubMed 3032952 http://www.ncbi.nlm.nih.gov/pubmed/3032952 PubMed 7779808 http://www.ncbi.nlm.nih.gov/pubmed/7779808 PubMed 8114910 http://www.ncbi.nlm.nih.gov/pubmed/8114910 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9497321 http://www.ncbi.nlm.nih.gov/pubmed/9497321 RefSeq NP_415790 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415790 RefSeq WP_001297122 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001297122 SMART SM00436 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00436 SMART SM00437 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00437 SMART SM00493 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00493 SMR P06612 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P06612 STRING 511145.b1274 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1274&targetmode=cogs STRING COG0550 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0550&targetmode=cogs STRING COG0551 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0551&targetmode=cogs STRING COG1754 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1754&targetmode=cogs SUPFAM SSF56712 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56712 TIGRFAMs TIGR01051 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01051 UniProtKB TOP1_ECOLI http://www.uniprot.org/uniprot/TOP1_ECOLI UniProtKB-AC P06612 http://www.uniprot.org/uniprot/P06612 charge swissprot:TOP1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TOP1_ECOLI eggNOG COG0550 http://eggnogapi.embl.de/nog_data/html/tree/COG0550 eggNOG COG0551 http://eggnogapi.embl.de/nog_data/html/tree/COG0551 eggNOG ENOG4105C73 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C73 epestfind swissprot:TOP1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TOP1_ECOLI garnier swissprot:TOP1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TOP1_ECOLI helixturnhelix swissprot:TOP1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TOP1_ECOLI hmoment swissprot:TOP1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TOP1_ECOLI iep swissprot:TOP1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TOP1_ECOLI inforesidue swissprot:TOP1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TOP1_ECOLI octanol swissprot:TOP1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TOP1_ECOLI pepcoil swissprot:TOP1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TOP1_ECOLI pepdigest swissprot:TOP1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TOP1_ECOLI pepinfo swissprot:TOP1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TOP1_ECOLI pepnet swissprot:TOP1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TOP1_ECOLI pepstats swissprot:TOP1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TOP1_ECOLI pepwheel swissprot:TOP1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TOP1_ECOLI pepwindow swissprot:TOP1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TOP1_ECOLI sigcleave swissprot:TOP1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TOP1_ECOLI ## Database ID URL or Descriptions # BioGrid 4262645 289 # CDD cd00383 trans_reg_C # DISRUPTION PHENOTYPE CPXR_ECOLI Loss of the Cpx envelope stress response (PubMed 10972835). A double cpxR-cpxA mutant decreases transcription of degP (PubMed 7883164). Cells are less sensitive to killing by nalidixic acid; double cpxR-srkA disruption mutants are as sensitive to killing as single srkA mutants, suggesting the SrkA protein kinase is partially regulated by CpxR. Hypersensitive to alkaline pH (greater than pH 8.8) (PubMed 9473036). Decreased numbers of stationary phase cells bind to hydrophobic surfaces, cellular adhesion has altered dynamic properties; no induction of cpxR when cells bind to hydrophobic surfaces (PubMed 11830644). {ECO 0000269|PubMed 10972835, ECO 0000269|PubMed 11830644, ECO 0000269|PubMed 23416055, ECO 0000269|PubMed 7883164, ECO 0000269|PubMed 9473036}. # ENZYME REGULATION CPXR_ECOLI The two-component system is activated by envelope stress such as overexpression of some (misfolded) periplasmic proteins (PubMed 7883164, PubMed 9351822). Activated by spheroplasting (which removes the periplasm) in an autoregulatory cpxA-cpxR-dependent fashion (PubMed 10972835). Cpx two-component system is activated at pH 8.0; in a degP deletion mutant activation is halved (PubMed 9473036, PubMed 16166523). The CpxA kinase activity is inhibited by periplasmic accessory protein CpxP; proteolysis of CpxP relieves inhibition (PubMed 16166523, PubMed 17259177, PubMed 25207645). {ECO 0000269|PubMed 10972835, ECO 0000269|PubMed 16166523, ECO 0000269|PubMed 7883164, ECO 0000269|PubMed 9351822, ECO 0000269|PubMed 9473036}. # EcoGene EG10020 cpxR # FUNCTION CPXR_ECOLI Response regulator member of the two-component regulatory system CpxA/CpxR which responds to envelope stress response by activating expression of downstream genes including cpxP, degP, dsbA and ppiA (PubMed 7883164, PubMed 9401031). Required for efficient binding of stationary phase cells to hydrophobic surfaces, part of the process of biofilm formation (PubMed 11830644). Induced upon cell surface binding, subsequently induces genes it controls (cpxP, dsbA and spy, degP is only partially induced) (PubMed 11830644). Binds and activates transcription from the degP promoter (PubMed 7883164); binding is enhanced by phosphorylation (PubMed 9401031). This system combats a variety of extracytoplasmic protein-mediated toxicities by increasing the transcription of the periplasmic protease, DegP in concert with sigma factor E (PubMed 7883164), as well as that of CpxP protein. Other downstream effectors may include SrkA (PubMed 23416055). {ECO 0000269|PubMed 11830644, ECO 0000269|PubMed 23416055, ECO 0000269|PubMed 7883164, ECO 0000269|PubMed 9401031}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0000160 phosphorelay signal transduction system; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0007155 cell adhesion; IEA:UniProtKB-KW. # GO_process GO:0010810 regulation of cell-substrate adhesion; IMP:UniProtKB. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IDA:CACAO. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0007155 cell adhesion # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # INDUCTION Induced about 3-fold when stationary phase cells bind to hydrophobic surfaces; requires direct contact with hydrophobic surfaces for up-regulation of Cpx activity (PubMed:11830644). {ECO 0000269|PubMed:11830644}. # INTERACTION CPXR_ECOLI P00861 lysA; NbExp=2; IntAct=EBI-550918, EBI-553837; # IntAct P0AE88 11 # InterPro IPR001789 Sig_transdc_resp-reg_receiver # InterPro IPR001867 OmpR/PhoB-type_DNA-bd # InterPro IPR011006 CheY-like_superfamily # InterPro IPR011991 WHTH_DNA-bd_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02022 M00447 CpxA-CpxR (envelope stress response) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # Organism CPXR_ECOLI Escherichia coli (strain K12) # PATRIC 32123337 VBIEscCol129921_4029 # PDB 4UHJ X-ray; 1.90 A; A/B/C=1-123 # PDB 4UHK X-ray; 2.60 A; A/B/C=1-123 # PDB 4UHS X-ray; 5.00 A; A/B/C=1-123 # PDB 4UHT X-ray; 1.15 A; A/B=131-231 # PIR C65197 C65197 # PROSITE PS50110 RESPONSE_REGULATORY # PROSITE PS51755 OMPR_PHOB # PTM CPXR_ECOLI Phosphorylated by CpxA. {ECO 0000269|PubMed 17259177, ECO 0000269|PubMed 9401031, ECO 0000305|PubMed 7883164}. # Pfam PF00072 Response_reg # Pfam PF00486 Trans_reg_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CPXR_ECOLI Transcriptional regulatory protein CpxR # RefSeq NP_418348 NC_000913.3 # RefSeq WP_001033722 NZ_LN832404.1 # SIMILARITY Contains 1 OmpR/PhoB-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU01091}. # SIMILARITY Contains 1 response regulatory domain. {ECO:0000255|PROSITE-ProRule PRU00169}. # SMART SM00448 REC # SMART SM00862 Trans_reg_C # SUBCELLULAR LOCATION CPXR_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Interacts with cognate sensor kinase CpxA. {ECO:0000269|PubMed 25207645}. # SUPFAM SSF52172 SSF52172 # eggNOG COG0745 LUCA # eggNOG ENOG4105E3W Bacteria BLAST swissprot:CPXR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CPXR_ECOLI BioCyc ECOL316407:JW3883-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3883-MONOMER BioCyc EcoCyc:CPXR-MONOMER http://biocyc.org/getid?id=EcoCyc:CPXR-MONOMER COG COG0745 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0745 DIP DIP-47991N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47991N DOI 10.1016/0022-2836(88)90013-7 http://dx.doi.org/10.1016/0022-2836(88)90013-7 DOI 10.1016/0378-1119(93)90469-J http://dx.doi.org/10.1016/0378-1119(93)90469-J DOI 10.1016/j.celrep.2013.01.026 http://dx.doi.org/10.1016/j.celrep.2013.01.026 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2000.02074.x http://dx.doi.org/10.1046/j.1365-2958.2000.02074.x DOI 10.1073/pnas.042521699 http://dx.doi.org/10.1073/pnas.042521699 DOI 10.1074/jbc.M605785200 http://dx.doi.org/10.1074/jbc.M605785200 DOI 10.1093/emboj/16.21.6394 http://dx.doi.org/10.1093/emboj/16.21.6394 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1101/gad.9.4.387 http://dx.doi.org/10.1101/gad.9.4.387 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.187.19.6622-6630.2005 http://dx.doi.org/10.1128/JB.187.19.6622-6630.2005 DOI 10.1371/journal.pone.0107383 http://dx.doi.org/10.1371/journal.pone.0107383 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L14579 http://www.ebi.ac.uk/ena/data/view/L14579 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL M36795 http://www.ebi.ac.uk/ena/data/view/M36795 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X13307 http://www.ebi.ac.uk/ena/data/view/X13307 EchoBASE EB0019 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0019 EcoGene EG10020 http://www.ecogene.org/geneInfo.php?eg_id=EG10020 EnsemblBacteria AAC76894 http://www.ensemblgenomes.org/id/AAC76894 EnsemblBacteria AAC76894 http://www.ensemblgenomes.org/id/AAC76894 EnsemblBacteria BAE77397 http://www.ensemblgenomes.org/id/BAE77397 EnsemblBacteria BAE77397 http://www.ensemblgenomes.org/id/BAE77397 EnsemblBacteria BAE77397 http://www.ensemblgenomes.org/id/BAE77397 EnsemblBacteria b3912 http://www.ensemblgenomes.org/id/b3912 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GO_process GO:0010810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010810 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 948404 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948404 HOGENOM HOG000034819 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000034819&db=HOGENOM6 InParanoid P0AE88 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AE88 IntAct P0AE88 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AE88* InterPro IPR001789 http://www.ebi.ac.uk/interpro/entry/IPR001789 InterPro IPR001867 http://www.ebi.ac.uk/interpro/entry/IPR001867 InterPro IPR011006 http://www.ebi.ac.uk/interpro/entry/IPR011006 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW3883 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3883 KEGG_Gene eco:b3912 http://www.genome.jp/dbget-bin/www_bget?eco:b3912 KEGG_Orthology KO:K07662 http://www.genome.jp/dbget-bin/www_bget?KO:K07662 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 MINT MINT-1292432 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1292432 OMA SMIGYNV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SMIGYNV PDB 4UHJ http://www.ebi.ac.uk/pdbe-srv/view/entry/4UHJ PDB 4UHK http://www.ebi.ac.uk/pdbe-srv/view/entry/4UHK PDB 4UHS http://www.ebi.ac.uk/pdbe-srv/view/entry/4UHS PDB 4UHT http://www.ebi.ac.uk/pdbe-srv/view/entry/4UHT PDBsum 4UHJ http://www.ebi.ac.uk/pdbsum/4UHJ PDBsum 4UHK http://www.ebi.ac.uk/pdbsum/4UHK PDBsum 4UHS http://www.ebi.ac.uk/pdbsum/4UHS PDBsum 4UHT http://www.ebi.ac.uk/pdbsum/4UHT PROSITE PS50110 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50110 PROSITE PS51755 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51755 PSORT swissprot:CPXR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CPXR_ECOLI PSORT-B swissprot:CPXR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CPXR_ECOLI PSORT2 swissprot:CPXR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CPXR_ECOLI Pfam PF00072 http://pfam.xfam.org/family/PF00072 Pfam PF00486 http://pfam.xfam.org/family/PF00486 Phobius swissprot:CPXR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CPXR_ECOLI PhylomeDB P0AE88 http://phylomedb.org/?seqid=P0AE88 ProteinModelPortal P0AE88 http://www.proteinmodelportal.org/query/uniprot/P0AE88 PubMed 10972835 http://www.ncbi.nlm.nih.gov/pubmed/10972835 PubMed 11830644 http://www.ncbi.nlm.nih.gov/pubmed/11830644 PubMed 16166523 http://www.ncbi.nlm.nih.gov/pubmed/16166523 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17259177 http://www.ncbi.nlm.nih.gov/pubmed/17259177 PubMed 23416055 http://www.ncbi.nlm.nih.gov/pubmed/23416055 PubMed 25207645 http://www.ncbi.nlm.nih.gov/pubmed/25207645 PubMed 3058985 http://www.ncbi.nlm.nih.gov/pubmed/3058985 PubMed 7883164 http://www.ncbi.nlm.nih.gov/pubmed/7883164 PubMed 8294007 http://www.ncbi.nlm.nih.gov/pubmed/8294007 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9351822 http://www.ncbi.nlm.nih.gov/pubmed/9351822 PubMed 9401031 http://www.ncbi.nlm.nih.gov/pubmed/9401031 PubMed 9473036 http://www.ncbi.nlm.nih.gov/pubmed/9473036 RefSeq NP_418348 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418348 RefSeq WP_001033722 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001033722 SMART SM00448 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00448 SMART SM00862 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00862 SMR P0AE88 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AE88 STRING 511145.b3912 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3912&targetmode=cogs STRING COG0745 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0745&targetmode=cogs SUPFAM SSF52172 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52172 UniProtKB CPXR_ECOLI http://www.uniprot.org/uniprot/CPXR_ECOLI UniProtKB-AC P0AE88 http://www.uniprot.org/uniprot/P0AE88 charge swissprot:CPXR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CPXR_ECOLI eggNOG COG0745 http://eggnogapi.embl.de/nog_data/html/tree/COG0745 eggNOG ENOG4105E3W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E3W epestfind swissprot:CPXR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CPXR_ECOLI garnier swissprot:CPXR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CPXR_ECOLI helixturnhelix swissprot:CPXR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CPXR_ECOLI hmoment swissprot:CPXR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CPXR_ECOLI iep swissprot:CPXR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CPXR_ECOLI inforesidue swissprot:CPXR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CPXR_ECOLI octanol swissprot:CPXR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CPXR_ECOLI pepcoil swissprot:CPXR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CPXR_ECOLI pepdigest swissprot:CPXR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CPXR_ECOLI pepinfo swissprot:CPXR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CPXR_ECOLI pepnet swissprot:CPXR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CPXR_ECOLI pepstats swissprot:CPXR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CPXR_ECOLI pepwheel swissprot:CPXR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CPXR_ECOLI pepwindow swissprot:CPXR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CPXR_ECOLI sigcleave swissprot:CPXR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CPXR_ECOLI ## Database ID URL or Descriptions # AltName DEDA_ECOLI Protein DSG-1 # BioGrid 4261363 8 # EcoGene EG10216 dedA # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR032816 SNARE_assoc # InterPro IPR032818 DedA # Organism DEDA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30353 PTHR30353 # PATRIC 32120005 VBIEscCol129921_2412 # PIR B29803 XMECAD # Pfam PF09335 SNARE_assoc # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DEDA_ECOLI Protein DedA # RefSeq NP_416820 NC_000913.3 # RefSeq WP_000364335 NZ_LN832404.1 # SIMILARITY Belongs to the DedA family. {ECO 0000305}. # SUBCELLULAR LOCATION DEDA_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 9.B.27.2 the deda or ydjx-z (deda) family # eggNOG COG0586 LUCA # eggNOG ENOG4105DQR Bacteria BLAST swissprot:DEDA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DEDA_ECOLI BioCyc ECOL316407:JW2314-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2314-MONOMER BioCyc EcoCyc:EG10216-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10216-MONOMER COG COG0586 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0586 DIP DIP-48027N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48027N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M15543 http://www.ebi.ac.uk/ena/data/view/M15543 EMBL M68934 http://www.ebi.ac.uk/ena/data/view/M68934 EMBL S53037 http://www.ebi.ac.uk/ena/data/view/S53037 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X02743 http://www.ebi.ac.uk/ena/data/view/X02743 EchoBASE EB0212 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0212 EcoGene EG10216 http://www.ecogene.org/geneInfo.php?eg_id=EG10216 EnsemblBacteria AAC75377 http://www.ensemblgenomes.org/id/AAC75377 EnsemblBacteria AAC75377 http://www.ensemblgenomes.org/id/AAC75377 EnsemblBacteria BAA16174 http://www.ensemblgenomes.org/id/BAA16174 EnsemblBacteria BAA16174 http://www.ensemblgenomes.org/id/BAA16174 EnsemblBacteria BAA16174 http://www.ensemblgenomes.org/id/BAA16174 EnsemblBacteria b2317 http://www.ensemblgenomes.org/id/b2317 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 946798 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946798 HOGENOM HOG000105368 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000105368&db=HOGENOM6 InParanoid P0ABP6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABP6 IntAct P0ABP6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABP6* InterPro IPR032816 http://www.ebi.ac.uk/interpro/entry/IPR032816 InterPro IPR032818 http://www.ebi.ac.uk/interpro/entry/IPR032818 KEGG_Gene ecj:JW2314 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2314 KEGG_Gene eco:b2317 http://www.genome.jp/dbget-bin/www_bget?eco:b2317 KEGG_Orthology KO:K03975 http://www.genome.jp/dbget-bin/www_bget?KO:K03975 OMA YLDKTHE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YLDKTHE PANTHER PTHR30353 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30353 PSORT swissprot:DEDA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DEDA_ECOLI PSORT-B swissprot:DEDA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DEDA_ECOLI PSORT2 swissprot:DEDA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DEDA_ECOLI Pfam PF09335 http://pfam.xfam.org/family/PF09335 Phobius swissprot:DEDA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DEDA_ECOLI PhylomeDB P0ABP6 http://phylomedb.org/?seqid=P0ABP6 ProteinModelPortal P0ABP6 http://www.proteinmodelportal.org/query/uniprot/P0ABP6 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3029016 http://www.ncbi.nlm.nih.gov/pubmed/3029016 PubMed 3040734 http://www.ncbi.nlm.nih.gov/pubmed/3040734 PubMed 7678242 http://www.ncbi.nlm.nih.gov/pubmed/7678242 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416820 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416820 RefSeq WP_000364335 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000364335 STRING 511145.b2317 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2317&targetmode=cogs STRING COG0586 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0586&targetmode=cogs TCDB 9.B.27.2 http://www.tcdb.org/search/result.php?tc=9.B.27.2 UniProtKB DEDA_ECOLI http://www.uniprot.org/uniprot/DEDA_ECOLI UniProtKB-AC P0ABP6 http://www.uniprot.org/uniprot/P0ABP6 charge swissprot:DEDA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DEDA_ECOLI eggNOG COG0586 http://eggnogapi.embl.de/nog_data/html/tree/COG0586 eggNOG ENOG4105DQR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DQR epestfind swissprot:DEDA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DEDA_ECOLI garnier swissprot:DEDA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DEDA_ECOLI helixturnhelix swissprot:DEDA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DEDA_ECOLI hmoment swissprot:DEDA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DEDA_ECOLI iep swissprot:DEDA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DEDA_ECOLI inforesidue swissprot:DEDA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DEDA_ECOLI octanol swissprot:DEDA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DEDA_ECOLI pepcoil swissprot:DEDA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DEDA_ECOLI pepdigest swissprot:DEDA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DEDA_ECOLI pepinfo swissprot:DEDA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DEDA_ECOLI pepnet swissprot:DEDA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DEDA_ECOLI pepstats swissprot:DEDA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DEDA_ECOLI pepwheel swissprot:DEDA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DEDA_ECOLI pepwindow swissprot:DEDA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DEDA_ECOLI sigcleave swissprot:DEDA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DEDA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260017 10 # CDD cd06261 TM_PBP2 # EcoGene EG13705 ssuC # FUNCTION SSUC_ECOLI Part of a binding-protein-dependent transport system for aliphatic sulfonates. Probably responsible for the translocation of the substrate across the membrane. # GO_component GO:0005886 plasma membrane; IBA:GO_Central. # GO_component GO:0005887 integral component of plasma membrane; ISM:EcoCyc. # GO_process GO:0006790 sulfur compound metabolic process; IGI:EcoliWiki. # GO_process GO:0006810 transport; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0006810 transport # Gene3D 1.10.3720.10 -; 1. # InterPro IPR000515 MetI-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00436 Sulfonate transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism SSUC_ECOLI Escherichia coli (strain K12) # PATRIC 32117087 VBIEscCol129921_0968 # PIR E64833 E64833 # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SSUC_ECOLI Putative aliphatic sulfonates transport permease protein SsuC # RefSeq NP_415454 NC_000913.3 # RefSeq WP_000235203 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION SSUC_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF161098 SSF161098 # TCDB 3.A.1.17.10 the atp-binding cassette (abc) superfamily # eggNOG COG0600 LUCA # eggNOG ENOG4105EFS Bacteria BLAST swissprot:SSUC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SSUC_ECOLI BioCyc ECOL316407:JW5121-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5121-MONOMER BioCyc EcoCyc:YCBM-MONOMER http://biocyc.org/getid?id=EcoCyc:YCBM-MONOMER BioCyc MetaCyc:YCBM-MONOMER http://biocyc.org/getid?id=MetaCyc:YCBM-MONOMER COG COG0600 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0600 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.052018199 http://dx.doi.org/10.1073/pnas.052018199 DOI 10.1074/jbc.274.41.29358 http://dx.doi.org/10.1074/jbc.274.41.29358 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AJ237695 http://www.ebi.ac.uk/ena/data/view/AJ237695 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3469 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3469 EcoGene EG13705 http://www.ecogene.org/geneInfo.php?eg_id=EG13705 EnsemblBacteria AAC74020 http://www.ensemblgenomes.org/id/AAC74020 EnsemblBacteria AAC74020 http://www.ensemblgenomes.org/id/AAC74020 EnsemblBacteria BAA35689 http://www.ensemblgenomes.org/id/BAA35689 EnsemblBacteria BAA35689 http://www.ensemblgenomes.org/id/BAA35689 EnsemblBacteria BAA35689 http://www.ensemblgenomes.org/id/BAA35689 EnsemblBacteria b0934 http://www.ensemblgenomes.org/id/b0934 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 947216 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947216 HOGENOM HOG000134230 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000134230&db=HOGENOM6 InParanoid P75851 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75851 InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5121 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5121 KEGG_Gene eco:b0934 http://www.genome.jp/dbget-bin/www_bget?eco:b0934 KEGG_Orthology KO:K15554 http://www.genome.jp/dbget-bin/www_bget?KO:K15554 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA YHGIRNI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YHGIRNI PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:SSUC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SSUC_ECOLI PSORT-B swissprot:SSUC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SSUC_ECOLI PSORT2 swissprot:SSUC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SSUC_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Phobius swissprot:SSUC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SSUC_ECOLI PhylomeDB P75851 http://phylomedb.org/?seqid=P75851 ProteinModelPortal P75851 http://www.proteinmodelportal.org/query/uniprot/P75851 PubMed 10506196 http://www.ncbi.nlm.nih.gov/pubmed/10506196 PubMed 11867724 http://www.ncbi.nlm.nih.gov/pubmed/11867724 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415454 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415454 RefSeq WP_000235203 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000235203 STRING 511145.b0934 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0934&targetmode=cogs STRING COG0600 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0600&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.17.10 http://www.tcdb.org/search/result.php?tc=3.A.1.17.10 UniProtKB SSUC_ECOLI http://www.uniprot.org/uniprot/SSUC_ECOLI UniProtKB-AC P75851 http://www.uniprot.org/uniprot/P75851 charge swissprot:SSUC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SSUC_ECOLI eggNOG COG0600 http://eggnogapi.embl.de/nog_data/html/tree/COG0600 eggNOG ENOG4105EFS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EFS epestfind swissprot:SSUC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SSUC_ECOLI garnier swissprot:SSUC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SSUC_ECOLI helixturnhelix swissprot:SSUC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SSUC_ECOLI hmoment swissprot:SSUC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SSUC_ECOLI iep swissprot:SSUC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SSUC_ECOLI inforesidue swissprot:SSUC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SSUC_ECOLI octanol swissprot:SSUC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SSUC_ECOLI pepcoil swissprot:SSUC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SSUC_ECOLI pepdigest swissprot:SSUC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SSUC_ECOLI pepinfo swissprot:SSUC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SSUC_ECOLI pepnet swissprot:SSUC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SSUC_ECOLI pepstats swissprot:SSUC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SSUC_ECOLI pepwheel swissprot:SSUC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SSUC_ECOLI pepwindow swissprot:SSUC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SSUC_ECOLI sigcleave swissprot:SSUC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SSUC_ECOLI ## Database ID URL or Descriptions # BioGrid 4260225 8 # EcoGene EG13805 lsrR # FUNCTION LSRR_ECOLI Regulates transcription of many different genes. In the absence of autoinducer 2 (AI-2), represses transcription of the lsrACDBFG operon and its own transcription. In the presence of AI- 2, LsrR is inactivated by binding phospho-AI-2, leading to the transcription of the lsr genes. {ECO 0000269|PubMed 15601708, ECO 0000269|PubMed 15743955, ECO 0000269|PubMed 17557827}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000986 bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding; IDA:EcoCyc. # GO_function GO:0030246 carbohydrate binding; IEA:InterPro. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEP:EcoCyc. # GO_process GO:0009408 response to heat; IMP:EcoCyc. # GO_process GO:2000142 regulation of DNA-templated transcription, initiation; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # INDUCTION LSRR_ECOLI Autoregulated. # IntAct P76141 5 # InterPro IPR007324 Sugar-bd_dom_put # InterPro IPR011991 WHTH_DNA-bd_dom # KEGG_Brite ko03000 Transcription factors # Organism LSRR_ECOLI Escherichia coli (strain K12) # PATRIC 32118320 VBIEscCol129921_1580 # PDB 4GO1 X-ray; 3.00 A; A/B=1-317 # PDB 4L4Y X-ray; 1.90 A; A/B=53-317 # PDB 4L4Z X-ray; 2.30 A; A/B=53-317 # PDB 4L50 X-ray; 2.10 A; A/B=53-317 # PDB 4L51 X-ray; 1.90 A; A/B=53-317 # PDB 4L5I X-ray; 3.21 A; A/B/C/D=1-317 # PDB 4L5J X-ray; 2.60 A; A/B/C/D=1-317 # PIR C64905 C64905 # Pfam PF04198 Sugar-bind # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LSRR_ECOLI Transcriptional regulator LsrR # RefSeq NP_416029 NC_000913.3 # RefSeq WP_000154342 NZ_LN832404.1 # SIMILARITY Belongs to the SorC transcriptional regulatory family. {ECO 0000305}. # SUBCELLULAR LOCATION LSRR_ECOLI Cytoplasm {ECO 0000305}. # eggNOG COG2390 LUCA # eggNOG ENOG4105DKT Bacteria BLAST swissprot:LSRR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LSRR_ECOLI BioCyc ECOL316407:JW1505-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1505-MONOMER BioCyc EcoCyc:G6799-MONOMER http://biocyc.org/getid?id=EcoCyc:G6799-MONOMER COG COG2390 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2390 DIP DIP-11688N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11688N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00014-07 http://dx.doi.org/10.1128/JB.00014-07 DOI 10.1128/JB.187.1.238-248.2005 http://dx.doi.org/10.1128/JB.187.1.238-248.2005 DOI 10.1128/JB.187.6.2066-2076.2005 http://dx.doi.org/10.1128/JB.187.6.2066-2076.2005 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3566 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3566 EcoGene EG13805 http://www.ecogene.org/geneInfo.php?eg_id=EG13805 EnsemblBacteria AAC74585 http://www.ensemblgenomes.org/id/AAC74585 EnsemblBacteria AAC74585 http://www.ensemblgenomes.org/id/AAC74585 EnsemblBacteria BAA15192 http://www.ensemblgenomes.org/id/BAA15192 EnsemblBacteria BAA15192 http://www.ensemblgenomes.org/id/BAA15192 EnsemblBacteria BAA15192 http://www.ensemblgenomes.org/id/BAA15192 EnsemblBacteria b1512 http://www.ensemblgenomes.org/id/b1512 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000986 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000986 GO_function GO:0030246 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030246 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GO_process GO:2000142 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000142 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 946070 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946070 HOGENOM HOG000243107 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000243107&db=HOGENOM6 InParanoid P76141 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76141 IntAct P76141 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76141* InterPro IPR007324 http://www.ebi.ac.uk/interpro/entry/IPR007324 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW1505 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1505 KEGG_Gene eco:b1512 http://www.genome.jp/dbget-bin/www_bget?eco:b1512 KEGG_Orthology KO:K11531 http://www.genome.jp/dbget-bin/www_bget?KO:K11531 OMA HQIMETA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HQIMETA PDB 4GO1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4GO1 PDB 4L4Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4L4Y PDB 4L4Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4L4Z PDB 4L50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4L50 PDB 4L51 http://www.ebi.ac.uk/pdbe-srv/view/entry/4L51 PDB 4L5I http://www.ebi.ac.uk/pdbe-srv/view/entry/4L5I PDB 4L5J http://www.ebi.ac.uk/pdbe-srv/view/entry/4L5J PDBsum 4GO1 http://www.ebi.ac.uk/pdbsum/4GO1 PDBsum 4L4Y http://www.ebi.ac.uk/pdbsum/4L4Y PDBsum 4L4Z http://www.ebi.ac.uk/pdbsum/4L4Z PDBsum 4L50 http://www.ebi.ac.uk/pdbsum/4L50 PDBsum 4L51 http://www.ebi.ac.uk/pdbsum/4L51 PDBsum 4L5I http://www.ebi.ac.uk/pdbsum/4L5I PDBsum 4L5J http://www.ebi.ac.uk/pdbsum/4L5J PSORT swissprot:LSRR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LSRR_ECOLI PSORT-B swissprot:LSRR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LSRR_ECOLI PSORT2 swissprot:LSRR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LSRR_ECOLI Pfam PF04198 http://pfam.xfam.org/family/PF04198 Phobius swissprot:LSRR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LSRR_ECOLI PhylomeDB P76141 http://phylomedb.org/?seqid=P76141 ProteinModelPortal P76141 http://www.proteinmodelportal.org/query/uniprot/P76141 PubMed 15601708 http://www.ncbi.nlm.nih.gov/pubmed/15601708 PubMed 15743955 http://www.ncbi.nlm.nih.gov/pubmed/15743955 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17557827 http://www.ncbi.nlm.nih.gov/pubmed/17557827 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416029 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416029 RefSeq WP_000154342 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000154342 SMR P76141 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76141 STRING 511145.b1512 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1512&targetmode=cogs STRING COG2390 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2390&targetmode=cogs UniProtKB LSRR_ECOLI http://www.uniprot.org/uniprot/LSRR_ECOLI UniProtKB-AC P76141 http://www.uniprot.org/uniprot/P76141 charge swissprot:LSRR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LSRR_ECOLI eggNOG COG2390 http://eggnogapi.embl.de/nog_data/html/tree/COG2390 eggNOG ENOG4105DKT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DKT epestfind swissprot:LSRR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LSRR_ECOLI garnier swissprot:LSRR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LSRR_ECOLI helixturnhelix swissprot:LSRR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LSRR_ECOLI hmoment swissprot:LSRR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LSRR_ECOLI iep swissprot:LSRR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LSRR_ECOLI inforesidue swissprot:LSRR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LSRR_ECOLI octanol swissprot:LSRR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LSRR_ECOLI pepcoil swissprot:LSRR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LSRR_ECOLI pepdigest swissprot:LSRR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LSRR_ECOLI pepinfo swissprot:LSRR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LSRR_ECOLI pepnet swissprot:LSRR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LSRR_ECOLI pepstats swissprot:LSRR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LSRR_ECOLI pepwheel swissprot:LSRR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LSRR_ECOLI pepwindow swissprot:LSRR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LSRR_ECOLI sigcleave swissprot:LSRR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LSRR_ECOLI ## Database ID URL or Descriptions # BioGrid 4262057 14 # EcoGene EG12812 yhcF # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_process GO:0006950 response to stress # IntAct P45422 2 # InterPro IPR010546 DUF1120 # Organism YHCF_ECOLI Escherichia coli (strain K12) # PATRIC 32121862 VBIEscCol129921_3315 # PIR E65113 E65113 # Pfam PF06551 DUF1120 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHCF_ECOLI Uncharacterized protein YhcF # RefSeq NP_417686 NC_000913.3 # RefSeq WP_001067008 NZ_LN832404.1 # SIMILARITY To E.coli GltF. {ECO 0000305}. # eggNOG ENOG4105UMR Bacteria # eggNOG ENOG4111UFK LUCA BLAST swissprot:YHCF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHCF_ECOLI BioCyc ECOL316407:JW3188-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3188-MONOMER BioCyc EcoCyc:G7673-MONOMER http://biocyc.org/getid?id=EcoCyc:G7673-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2663 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2663 EcoGene EG12812 http://www.ecogene.org/geneInfo.php?eg_id=EG12812 EnsemblBacteria AAC76251 http://www.ensemblgenomes.org/id/AAC76251 EnsemblBacteria AAC76251 http://www.ensemblgenomes.org/id/AAC76251 EnsemblBacteria BAE77262 http://www.ensemblgenomes.org/id/BAE77262 EnsemblBacteria BAE77262 http://www.ensemblgenomes.org/id/BAE77262 EnsemblBacteria BAE77262 http://www.ensemblgenomes.org/id/BAE77262 EnsemblBacteria b3219 http://www.ensemblgenomes.org/id/b3219 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 947735 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947735 HOGENOM HOG000260641 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260641&db=HOGENOM6 InParanoid P45422 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45422 IntAct P45422 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45422* InterPro IPR010546 http://www.ebi.ac.uk/interpro/entry/IPR010546 KEGG_Gene ecj:JW3188 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3188 KEGG_Gene eco:b3219 http://www.genome.jp/dbget-bin/www_bget?eco:b3219 OMA TISCDAP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TISCDAP PSORT swissprot:YHCF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHCF_ECOLI PSORT-B swissprot:YHCF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHCF_ECOLI PSORT2 swissprot:YHCF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHCF_ECOLI Pfam PF06551 http://pfam.xfam.org/family/PF06551 Phobius swissprot:YHCF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHCF_ECOLI ProteinModelPortal P45422 http://www.proteinmodelportal.org/query/uniprot/P45422 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417686 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417686 RefSeq WP_001067008 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001067008 STRING 511145.b3219 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3219&targetmode=cogs UniProtKB YHCF_ECOLI http://www.uniprot.org/uniprot/YHCF_ECOLI UniProtKB-AC P45422 http://www.uniprot.org/uniprot/P45422 charge swissprot:YHCF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHCF_ECOLI eggNOG ENOG4105UMR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105UMR eggNOG ENOG4111UFK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111UFK epestfind swissprot:YHCF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHCF_ECOLI garnier swissprot:YHCF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHCF_ECOLI helixturnhelix swissprot:YHCF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHCF_ECOLI hmoment swissprot:YHCF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHCF_ECOLI iep swissprot:YHCF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHCF_ECOLI inforesidue swissprot:YHCF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHCF_ECOLI octanol swissprot:YHCF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHCF_ECOLI pepcoil swissprot:YHCF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHCF_ECOLI pepdigest swissprot:YHCF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHCF_ECOLI pepinfo swissprot:YHCF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHCF_ECOLI pepnet swissprot:YHCF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHCF_ECOLI pepstats swissprot:YHCF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHCF_ECOLI pepwheel swissprot:YHCF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHCF_ECOLI pepwindow swissprot:YHCF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHCF_ECOLI sigcleave swissprot:YHCF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHCF_ECOLI ## Database ID URL or Descriptions # AltName OGRK_ECOLI Prophage P2 OGR protein # BioGrid 4261755 10 # EcoGene EG12425 ogrK # FUNCTION OGRK_ECOLI Cryptic version of the phage P2 OGR protein which acts as an activator of P2 late transcription. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # IntAct P37057 2 # InterPro IPR007684 Znf_Ogr/Delta # Organism OGRK_ECOLI Escherichia coli (strain K12) # PATRIC 32119499 VBIEscCol129921_2160 # PIR A41889 A41889 # Pfam PF04606 Ogr_Delta # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Prophage late control protein OgrK {ECO 0000305} # RefSeq NP_416586 NC_000913.3 # eggNOG ENOG4105ZTC Bacteria # eggNOG ENOG41128D7 LUCA BLAST swissprot:OGRK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:OGRK_ECOLI BioCyc ECOL316407:JW2067-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2067-MONOMER BioCyc EcoCyc:G7119-MONOMER http://biocyc.org/getid?id=EcoCyc:G7119-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M81463 http://www.ebi.ac.uk/ena/data/view/M81463 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2324 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2324 EcoGene EG12425 http://www.ecogene.org/geneInfo.php?eg_id=EG12425 EnsemblBacteria AAC75143 http://www.ensemblgenomes.org/id/AAC75143 EnsemblBacteria AAC75143 http://www.ensemblgenomes.org/id/AAC75143 EnsemblBacteria BAA15937 http://www.ensemblgenomes.org/id/BAA15937 EnsemblBacteria BAA15937 http://www.ensemblgenomes.org/id/BAA15937 EnsemblBacteria BAA15937 http://www.ensemblgenomes.org/id/BAA15937 EnsemblBacteria b2082 http://www.ensemblgenomes.org/id/b2082 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 945404 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945404 HOGENOM HOG000277112 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000277112&db=HOGENOM6 IntAct P37057 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37057* InterPro IPR007684 http://www.ebi.ac.uk/interpro/entry/IPR007684 KEGG_Gene ecj:JW2067 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2067 KEGG_Gene eco:b2082 http://www.genome.jp/dbget-bin/www_bget?eco:b2082 OMA MHCPLCG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MHCPLCG PSORT swissprot:OGRK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:OGRK_ECOLI PSORT-B swissprot:OGRK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:OGRK_ECOLI PSORT2 swissprot:OGRK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:OGRK_ECOLI Pfam PF04606 http://pfam.xfam.org/family/PF04606 Phobius swissprot:OGRK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:OGRK_ECOLI ProteinModelPortal P37057 http://www.proteinmodelportal.org/query/uniprot/P37057 PubMed 1597423 http://www.ncbi.nlm.nih.gov/pubmed/1597423 PubMed 1597424 http://www.ncbi.nlm.nih.gov/pubmed/1597424 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416586 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416586 STRING 511145.b2082 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2082&targetmode=cogs UniProtKB OGRK_ECOLI http://www.uniprot.org/uniprot/OGRK_ECOLI UniProtKB-AC P37057 http://www.uniprot.org/uniprot/P37057 charge swissprot:OGRK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:OGRK_ECOLI eggNOG ENOG4105ZTC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ZTC eggNOG ENOG41128D7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41128D7 epestfind swissprot:OGRK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:OGRK_ECOLI garnier swissprot:OGRK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:OGRK_ECOLI helixturnhelix swissprot:OGRK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:OGRK_ECOLI hmoment swissprot:OGRK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:OGRK_ECOLI iep swissprot:OGRK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:OGRK_ECOLI inforesidue swissprot:OGRK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:OGRK_ECOLI octanol swissprot:OGRK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:OGRK_ECOLI pepcoil swissprot:OGRK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:OGRK_ECOLI pepdigest swissprot:OGRK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:OGRK_ECOLI pepinfo swissprot:OGRK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:OGRK_ECOLI pepnet swissprot:OGRK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:OGRK_ECOLI pepstats swissprot:OGRK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:OGRK_ECOLI pepwheel swissprot:OGRK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:OGRK_ECOLI pepwindow swissprot:OGRK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:OGRK_ECOLI sigcleave swissprot:OGRK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:OGRK_ECOLI ## Database ID URL or Descriptions # BioGrid 4262871 13 # EcoGene EG13891 ycgJ # InterPro IPR008617 Uncharacterised_YcgJ # Organism YCGJ_ECOLI Escherichia coli (strain K12) # PATRIC 32117598 VBIEscCol129921_1221 # PIR F64863 F64863 # Pfam PF05666 Fels1; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCGJ_ECOLI Uncharacterized protein YcgJ # RefSeq NP_415695 NC_000913.3 # RefSeq WP_001056840 NZ_LN832404.1 # eggNOG ENOG4105S66 Bacteria # eggNOG ENOG4111XFY LUCA BLAST swissprot:YCGJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCGJ_ECOLI BioCyc ECOL316407:JW1166-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1166-MONOMER BioCyc EcoCyc:G6614-MONOMER http://biocyc.org/getid?id=EcoCyc:G6614-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3650 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3650 EcoGene EG13891 http://www.ecogene.org/geneInfo.php?eg_id=EG13891 EnsemblBacteria AAC74261 http://www.ensemblgenomes.org/id/AAC74261 EnsemblBacteria AAC74261 http://www.ensemblgenomes.org/id/AAC74261 EnsemblBacteria BAA36011 http://www.ensemblgenomes.org/id/BAA36011 EnsemblBacteria BAA36011 http://www.ensemblgenomes.org/id/BAA36011 EnsemblBacteria BAA36011 http://www.ensemblgenomes.org/id/BAA36011 EnsemblBacteria b1177 http://www.ensemblgenomes.org/id/b1177 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946155 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946155 HOGENOM HOG000119735 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000119735&db=HOGENOM6 InterPro IPR008617 http://www.ebi.ac.uk/interpro/entry/IPR008617 KEGG_Gene ecj:JW1166 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1166 KEGG_Gene eco:b1177 http://www.genome.jp/dbget-bin/www_bget?eco:b1177 OMA NGIFCDV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NGIFCDV PSORT swissprot:YCGJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCGJ_ECOLI PSORT-B swissprot:YCGJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCGJ_ECOLI PSORT2 swissprot:YCGJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCGJ_ECOLI Pfam PF05666 http://pfam.xfam.org/family/PF05666 Phobius swissprot:YCGJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCGJ_ECOLI ProteinModelPortal P76001 http://www.proteinmodelportal.org/query/uniprot/P76001 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415695 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415695 RefSeq WP_001056840 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001056840 STRING 511145.b1177 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1177&targetmode=cogs UniProtKB YCGJ_ECOLI http://www.uniprot.org/uniprot/YCGJ_ECOLI UniProtKB-AC P76001 http://www.uniprot.org/uniprot/P76001 charge swissprot:YCGJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCGJ_ECOLI eggNOG ENOG4105S66 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105S66 eggNOG ENOG4111XFY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111XFY epestfind swissprot:YCGJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCGJ_ECOLI garnier swissprot:YCGJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCGJ_ECOLI helixturnhelix swissprot:YCGJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCGJ_ECOLI hmoment swissprot:YCGJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCGJ_ECOLI iep swissprot:YCGJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCGJ_ECOLI inforesidue swissprot:YCGJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCGJ_ECOLI octanol swissprot:YCGJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCGJ_ECOLI pepcoil swissprot:YCGJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCGJ_ECOLI pepdigest swissprot:YCGJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCGJ_ECOLI pepinfo swissprot:YCGJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCGJ_ECOLI pepnet swissprot:YCGJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCGJ_ECOLI pepstats swissprot:YCGJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCGJ_ECOLI pepwheel swissprot:YCGJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCGJ_ECOLI pepwindow swissprot:YCGJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCGJ_ECOLI sigcleave swissprot:YCGJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCGJ_ECOLI ## Database ID URL or Descriptions # CDD cd07185 OmpA_C-like # DISRUPTION PHENOTYPE No visible phenotype. {ECO:0000269|PubMed 21228468}. # EcoGene EG12271 yiaD # FUNCTION YIAD_ECOLI Suppresses temperature-sensitive mutations in BamB when overexpressed. {ECO 0000269|PubMed 21228468}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0009279 cell outer membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # Gene3D 3.30.1330.60 -; 1. # IntAct P37665 2 # InterPro IPR006664 OMP_bac # InterPro IPR006665 OmpA-like # InterPro IPR006690 OMPA-like_CS # Organism YIAD_ECOLI Escherichia coli (strain K12) # PATRIC 32122576 VBIEscCol129921_3665 # PDB 2K1S NMR; -; A=79-219 # PDB 2N48 NMR; -; A=79-219 # PIR S47773 S47773 # PRINTS PR01021 OMPADOMAIN # PROSITE PS01068 OMPA_1 # PROSITE PS51123 OMPA_2 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF00691 OmpA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIAD_ECOLI Probable lipoprotein YiaD # RefSeq WP_000747625 NZ_LN832404.1 # RefSeq YP_026228 NC_000913.3 # SEQUENCE CAUTION Sequence=M34827; Type=Frameshift; Positions=88; Evidence={ECO 0000305}; # SIMILARITY Belongs to the OmpA family. {ECO 0000305}. # SIMILARITY Contains 1 OmpA-like domain. {ECO:0000255|PROSITE- ProRule PRU00473}. # SUBCELLULAR LOCATION YIAD_ECOLI Cell inner membrane {ECO 0000305}; Multi- pass membrane protein {ECO 0000305}. Cell outer membrane {ECO 0000305}; Lipid-anchor {ECO 0000305}. # SUPFAM SSF103088 SSF103088 # TCDB 9.B.186.1 the putative lipoprotein supressor of a ts bamd mutant, yiad (yiad) family # eggNOG COG2885 LUCA # eggNOG ENOG4108ZG0 Bacteria BLAST swissprot:YIAD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIAD_ECOLI BioCyc ECOL316407:JW5657-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5657-MONOMER BioCyc EcoCyc:EG12271-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12271-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1271/bbb.100612 http://dx.doi.org/10.1271/bbb.100612 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M34827 http://www.ebi.ac.uk/ena/data/view/M34827 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2180 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2180 EcoGene EG12271 http://www.ecogene.org/geneInfo.php?eg_id=EG12271 EnsemblBacteria AAT48190 http://www.ensemblgenomes.org/id/AAT48190 EnsemblBacteria AAT48190 http://www.ensemblgenomes.org/id/AAT48190 EnsemblBacteria BAE77743 http://www.ensemblgenomes.org/id/BAE77743 EnsemblBacteria BAE77743 http://www.ensemblgenomes.org/id/BAE77743 EnsemblBacteria BAE77743 http://www.ensemblgenomes.org/id/BAE77743 EnsemblBacteria b3552 http://www.ensemblgenomes.org/id/b3552 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 Gene3D 3.30.1330.60 http://www.cathdb.info/version/latest/superfamily/3.30.1330.60 GeneID 948075 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948075 HOGENOM HOG000189914 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000189914&db=HOGENOM6 InParanoid P37665 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37665 IntAct P37665 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37665* InterPro IPR006664 http://www.ebi.ac.uk/interpro/entry/IPR006664 InterPro IPR006665 http://www.ebi.ac.uk/interpro/entry/IPR006665 InterPro IPR006690 http://www.ebi.ac.uk/interpro/entry/IPR006690 KEGG_Gene ecj:JW5657 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5657 KEGG_Gene eco:b3552 http://www.genome.jp/dbget-bin/www_bget?eco:b3552 OMA IGNYMDQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IGNYMDQ PDB 2K1S http://www.ebi.ac.uk/pdbe-srv/view/entry/2K1S PDB 2N48 http://www.ebi.ac.uk/pdbe-srv/view/entry/2N48 PDBsum 2K1S http://www.ebi.ac.uk/pdbsum/2K1S PDBsum 2N48 http://www.ebi.ac.uk/pdbsum/2N48 PRINTS PR01021 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01021 PROSITE PS01068 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01068 PROSITE PS51123 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51123 PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:YIAD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIAD_ECOLI PSORT-B swissprot:YIAD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIAD_ECOLI PSORT2 swissprot:YIAD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIAD_ECOLI Pfam PF00691 http://pfam.xfam.org/family/PF00691 Phobius swissprot:YIAD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIAD_ECOLI PhylomeDB P37665 http://phylomedb.org/?seqid=P37665 ProteinModelPortal P37665 http://www.proteinmodelportal.org/query/uniprot/P37665 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21228468 http://www.ncbi.nlm.nih.gov/pubmed/21228468 PubMed 2180922 http://www.ncbi.nlm.nih.gov/pubmed/2180922 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000747625 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000747625 RefSeq YP_026228 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026228 SMR P37665 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37665 STRING 511145.b3552 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3552&targetmode=cogs SUPFAM SSF103088 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103088 TCDB 9.B.186.1 http://www.tcdb.org/search/result.php?tc=9.B.186.1 UniProtKB YIAD_ECOLI http://www.uniprot.org/uniprot/YIAD_ECOLI UniProtKB-AC P37665 http://www.uniprot.org/uniprot/P37665 charge swissprot:YIAD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIAD_ECOLI eggNOG COG2885 http://eggnogapi.embl.de/nog_data/html/tree/COG2885 eggNOG ENOG4108ZG0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZG0 epestfind swissprot:YIAD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIAD_ECOLI garnier swissprot:YIAD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIAD_ECOLI helixturnhelix swissprot:YIAD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIAD_ECOLI hmoment swissprot:YIAD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIAD_ECOLI iep swissprot:YIAD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIAD_ECOLI inforesidue swissprot:YIAD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIAD_ECOLI octanol swissprot:YIAD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIAD_ECOLI pepcoil swissprot:YIAD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIAD_ECOLI pepdigest swissprot:YIAD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIAD_ECOLI pepinfo swissprot:YIAD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIAD_ECOLI pepnet swissprot:YIAD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIAD_ECOLI pepstats swissprot:YIAD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIAD_ECOLI pepwheel swissprot:YIAD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIAD_ECOLI pepwindow swissprot:YIAD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIAD_ECOLI sigcleave swissprot:YIAD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIAD_ECOLI ## Database ID URL or Descriptions # BioGrid 4263425 12 # CDD cd01714 ETF_beta # EcoGene EG13976 ydiQ # FUNCTION YDIQ_ECOLI May play a role in a redox process. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0009055 electron carrier activity; IBA:GO_Central. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0055114 oxidation-reduction process; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.620 -; 1. # InterPro IPR000049 ET-Flavoprotein_bsu_CS # InterPro IPR012255 ETF_b # InterPro IPR014729 Rossmann-like_a/b/a_fold # InterPro IPR014730 ETF_a/b_N # InterPro IPR033948 ETF_beta_N # Organism YDIQ_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21294 PTHR21294 # PATRIC 32118700 VBIEscCol129921_1768 # PIR A64928 A64928 # PIRSF PIRSF000090 Beta-ETF # PROSITE PS01065 ETF_BETA # Pfam PF01012 ETF # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDIQ_ECOLI Putative electron transfer flavoprotein subunit YdiQ # RefSeq NP_416212 NC_000913.3 # RefSeq WP_000692135 NZ_LN832404.1 # SIMILARITY Belongs to the ETF beta-subunit/FixA family. {ECO 0000305}. # SMART SM00893 ETF # SUBUNIT YdiR and YdiQ form a heterodimer. {ECO 0000305}. # eggNOG COG2086 LUCA # eggNOG ENOG4105CV7 Bacteria BLAST swissprot:YDIQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDIQ_ECOLI BioCyc ECOL316407:JW5276-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5276-MONOMER BioCyc EcoCyc:G6920-MONOMER http://biocyc.org/getid?id=EcoCyc:G6920-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3733 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3733 EcoGene EG13976 http://www.ecogene.org/geneInfo.php?eg_id=EG13976 EnsemblBacteria AAC74767 http://www.ensemblgenomes.org/id/AAC74767 EnsemblBacteria AAC74767 http://www.ensemblgenomes.org/id/AAC74767 EnsemblBacteria BAA15466 http://www.ensemblgenomes.org/id/BAA15466 EnsemblBacteria BAA15466 http://www.ensemblgenomes.org/id/BAA15466 EnsemblBacteria BAA15466 http://www.ensemblgenomes.org/id/BAA15466 EnsemblBacteria b1697 http://www.ensemblgenomes.org/id/b1697 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0055114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 GeneID 946482 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946482 HOGENOM HOG000247880 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000247880&db=HOGENOM6 InParanoid P76201 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76201 IntAct P76201 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76201* InterPro IPR000049 http://www.ebi.ac.uk/interpro/entry/IPR000049 InterPro IPR012255 http://www.ebi.ac.uk/interpro/entry/IPR012255 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 InterPro IPR014730 http://www.ebi.ac.uk/interpro/entry/IPR014730 InterPro IPR033948 http://www.ebi.ac.uk/interpro/entry/IPR033948 KEGG_Gene ecj:JW5276 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5276 KEGG_Gene eco:b1697 http://www.genome.jp/dbget-bin/www_bget?eco:b1697 OMA TSDINMP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TSDINMP PANTHER PTHR21294 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21294 PROSITE PS01065 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01065 PSORT swissprot:YDIQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDIQ_ECOLI PSORT-B swissprot:YDIQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDIQ_ECOLI PSORT2 swissprot:YDIQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDIQ_ECOLI Pfam PF01012 http://pfam.xfam.org/family/PF01012 Phobius swissprot:YDIQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDIQ_ECOLI PhylomeDB P76201 http://phylomedb.org/?seqid=P76201 ProteinModelPortal P76201 http://www.proteinmodelportal.org/query/uniprot/P76201 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416212 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416212 RefSeq WP_000692135 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000692135 SMART SM00893 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00893 SMR P76201 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76201 STRING 511145.b1697 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1697&targetmode=cogs UniProtKB YDIQ_ECOLI http://www.uniprot.org/uniprot/YDIQ_ECOLI UniProtKB-AC P76201 http://www.uniprot.org/uniprot/P76201 charge swissprot:YDIQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDIQ_ECOLI eggNOG COG2086 http://eggnogapi.embl.de/nog_data/html/tree/COG2086 eggNOG ENOG4105CV7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CV7 epestfind swissprot:YDIQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDIQ_ECOLI garnier swissprot:YDIQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDIQ_ECOLI helixturnhelix swissprot:YDIQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDIQ_ECOLI hmoment swissprot:YDIQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDIQ_ECOLI iep swissprot:YDIQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDIQ_ECOLI inforesidue swissprot:YDIQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDIQ_ECOLI octanol swissprot:YDIQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDIQ_ECOLI pepcoil swissprot:YDIQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDIQ_ECOLI pepdigest swissprot:YDIQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDIQ_ECOLI pepinfo swissprot:YDIQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDIQ_ECOLI pepnet swissprot:YDIQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDIQ_ECOLI pepstats swissprot:YDIQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDIQ_ECOLI pepwheel swissprot:YDIQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDIQ_ECOLI pepwindow swissprot:YDIQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDIQ_ECOLI sigcleave swissprot:YDIQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDIQ_ECOLI ## Database ID URL or Descriptions # AltName DNAJ_ECOLI HSP40 # AltName DNAJ_ECOLI Heat shock protein J # BioGrid 4259725 176 # CDD cd06257 DnaJ # COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI 29105; Note=Binds 2 Zn(2+) ions per monomer.; # DISRUPTION PHENOTYPE Single dnaJ and double dnaK-dnaJ disruption are non-essential; synthetic lethality is seen in a triple tig- dnaK-dnaJ disruption, although this depends on temperature (triple disruptions grow slowly at 20 and 34 degrees Celsius but not at 43 degrees) and strain background. {ECO:0000269|PubMed 14726952}. # DOMAIN DNAJ_ECOLI The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity. # EcoGene EG10240 dnaJ # FUNCTION DNAJ_ECOLI Interacts with DnaK and GrpE to disassemble a protein complex at the origins of replication of phage lambda and several plasmids. Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. {ECO 0000269|PubMed 15044009, ECO 0000269|PubMed 15302880, ECO 0000269|PubMed 15485812, ECO 0000269|PubMed 1826368}. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:EcoliWiki. # GO_function GO:0003756 protein disulfide isomerase activity; IDA:EcoliWiki. # GO_function GO:0005524 ATP binding; IEA:InterPro. # GO_function GO:0008270 zinc ion binding; IDA:EcoliWiki. # GO_function GO:0015035 protein disulfide oxidoreductase activity; IDA:EcoCyc. # GO_function GO:0016989 sigma factor antagonist activity; IDA:EcoCyc. # GO_function GO:0051082 unfolded protein binding; IDA:EcoliWiki. # GO_process GO:0006260 DNA replication; IMP:EcoliWiki. # GO_process GO:0006457 protein folding; IDA:EcoliWiki. # GO_process GO:0009408 response to heat; IMP:EcoCyc. # GO_process GO:0016032 viral process; IDA:EcoCyc. # GO_process GO:0042026 protein refolding; IDA:EcoliWiki. # GO_process GO:0070389 chaperone cofactor-dependent protein refolding; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0000988 transcription factor activity, protein binding # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_function GO:0051082 unfolded protein binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006457 protein folding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044403 symbiosis, encompassing mutualism through parasitism # Gene3D 1.10.287.110 -; 1. # Gene3D 2.10.230.10 -; 1. # HAMAP MF_01152 DnaJ # INDUCTION DNAJ_ECOLI By heat shock under the control of the HtpR regulatory protein. # INTERACTION DNAJ_ECOLI P0A6Y8 dnaK; NbExp=5; IntAct=EBI-545285, EBI-542092; P06993 malT; NbExp=3; IntAct=EBI-545285, EBI-542934; # IntAct P08622 95 # InterPro IPR001305 HSP_DnaJ_Cys-rich_dom # InterPro IPR001623 DnaJ_domain # InterPro IPR002939 DnaJ_C # InterPro IPR008971 HSP40/DnaJ_pept-bd # InterPro IPR012724 DnaJ # InterPro IPR018253 DnaJ_domain_CS # KEGG_Brite ko03110 Chaperones and folding catalysts # Organism DNAJ_ECOLI Escherichia coli (strain K12) # PATRIC 32115123 VBIEscCol129921_0013 # PDB 1BQ0 NMR; -; A=2-104 # PDB 1BQZ NMR; -; A=2-78 # PDB 1EXK NMR; -; A=131-209 # PDB 1XBL NMR; -; A=2-108 # PIR A92572 HHECDJ # PRINTS PR00625 JDOMAIN # PROSITE PS00636 DNAJ_1 # PROSITE PS50076 DNAJ_2 # PROSITE PS51188 ZF_CR # Pfam PF00226 DnaJ # Pfam PF00684 DnaJ_CXXCXGXG # Pfam PF01556 DnaJ_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DNAJ_ECOLI Chaperone protein DnaJ # RefSeq NP_414556 NC_000913.3 # RefSeq WP_001118476 NZ_LN832404.1 # SIMILARITY Belongs to the DnaJ family. {ECO 0000305}. # SIMILARITY Contains 1 CR-type zinc finger. {ECO 0000305}. # SIMILARITY Contains 1 J domain. {ECO 0000305}. # SMART SM00271 DnaJ # SUBCELLULAR LOCATION DNAJ_ECOLI Cytoplasm. # SUBUNIT DNAJ_ECOLI Homodimer. # SUPFAM SSF46565 SSF46565 # SUPFAM SSF49493 SSF49493; 3 # SUPFAM SSF57938 SSF57938 # TIGRFAMs TIGR02349 DnaJ_bact # eggNOG COG0484 LUCA # eggNOG ENOG4105BZ5 Bacteria BLAST swissprot:DNAJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DNAJ_ECOLI BioCyc ECOL316407:JW0014-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0014-MONOMER BioCyc EcoCyc:EG10240-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10240-MONOMER BioCyc MetaCyc:EG10240-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10240-MONOMER COG COG0484 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0484 DIP DIP-9460N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9460N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/jmbi.1996.0395 http://dx.doi.org/10.1006/jmbi.1996.0395 DOI 10.1006/jmbi.2000.3923 http://dx.doi.org/10.1006/jmbi.2000.3923 DOI 10.1016/S0014-5793(04)00190-5 http://dx.doi.org/10.1016/S0014-5793(04)00190-5 DOI 10.1021/bi0480943 http://dx.doi.org/10.1021/bi0480943 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/sj.embor.7400067 http://dx.doi.org/10.1038/sj.embor.7400067 DOI 10.1073/pnas.88.7.2874 http://dx.doi.org/10.1073/pnas.88.7.2874 DOI 10.1073/pnas.95.26.15223 http://dx.doi.org/10.1073/pnas.95.26.15223 DOI 10.1074/jbc.M307491200 http://dx.doi.org/10.1074/jbc.M307491200 DOI 10.1074/jbc.M308782200 http://dx.doi.org/10.1074/jbc.M308782200 DOI 10.1074/jbc.M402405200 http://dx.doi.org/10.1074/jbc.M402405200 DOI 10.1074/jbc.M407531200 http://dx.doi.org/10.1074/jbc.M407531200 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1110/ps.8.1.203 http://dx.doi.org/10.1110/ps.8.1.203 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M12544 http://www.ebi.ac.uk/ena/data/view/M12544 EMBL M12565 http://www.ebi.ac.uk/ena/data/view/M12565 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0236 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0236 EcoGene EG10240 http://www.ecogene.org/geneInfo.php?eg_id=EG10240 EnsemblBacteria AAC73126 http://www.ensemblgenomes.org/id/AAC73126 EnsemblBacteria AAC73126 http://www.ensemblgenomes.org/id/AAC73126 EnsemblBacteria BAB96590 http://www.ensemblgenomes.org/id/BAB96590 EnsemblBacteria BAB96590 http://www.ensemblgenomes.org/id/BAB96590 EnsemblBacteria BAB96590 http://www.ensemblgenomes.org/id/BAB96590 EnsemblBacteria b0015 http://www.ensemblgenomes.org/id/b0015 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0003756 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003756 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0015035 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015035 GO_function GO:0016989 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016989 GO_function GO:0051082 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051082 GO_process GO:0006260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260 GO_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GO_process GO:0016032 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016032 GO_process GO:0042026 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042026 GO_process GO:0070389 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070389 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0000988 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000988 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_function GO:0051082 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051082 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403 Gene3D 1.10.287.110 http://www.cathdb.info/version/latest/superfamily/1.10.287.110 Gene3D 2.10.230.10 http://www.cathdb.info/version/latest/superfamily/2.10.230.10 GeneID 944753 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944753 HAMAP MF_01152 http://hamap.expasy.org/unirule/MF_01152 HOGENOM HOG000226717 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000226717&db=HOGENOM6 InParanoid P08622 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P08622 IntAct P08622 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P08622* InterPro IPR001305 http://www.ebi.ac.uk/interpro/entry/IPR001305 InterPro IPR001623 http://www.ebi.ac.uk/interpro/entry/IPR001623 InterPro IPR002939 http://www.ebi.ac.uk/interpro/entry/IPR002939 InterPro IPR008971 http://www.ebi.ac.uk/interpro/entry/IPR008971 InterPro IPR012724 http://www.ebi.ac.uk/interpro/entry/IPR012724 InterPro IPR018253 http://www.ebi.ac.uk/interpro/entry/IPR018253 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW0014 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0014 KEGG_Gene eco:b0015 http://www.genome.jp/dbget-bin/www_bget?eco:b0015 KEGG_Orthology KO:K03686 http://www.genome.jp/dbget-bin/www_bget?KO:K03686 MINT MINT-1220303 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1220303 OMA IKDPCNS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IKDPCNS PDB 1BQ0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1BQ0 PDB 1BQZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1BQZ PDB 1EXK http://www.ebi.ac.uk/pdbe-srv/view/entry/1EXK PDB 1XBL http://www.ebi.ac.uk/pdbe-srv/view/entry/1XBL PDBsum 1BQ0 http://www.ebi.ac.uk/pdbsum/1BQ0 PDBsum 1BQZ http://www.ebi.ac.uk/pdbsum/1BQZ PDBsum 1EXK http://www.ebi.ac.uk/pdbsum/1EXK PDBsum 1XBL http://www.ebi.ac.uk/pdbsum/1XBL PRINTS PR00625 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00625 PROSITE PS00636 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00636 PROSITE PS50076 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50076 PROSITE PS51188 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51188 PSORT swissprot:DNAJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DNAJ_ECOLI PSORT-B swissprot:DNAJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DNAJ_ECOLI PSORT2 swissprot:DNAJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DNAJ_ECOLI Pfam PF00226 http://pfam.xfam.org/family/PF00226 Pfam PF00684 http://pfam.xfam.org/family/PF00684 Pfam PF01556 http://pfam.xfam.org/family/PF01556 Phobius swissprot:DNAJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DNAJ_ECOLI PhylomeDB P08622 http://phylomedb.org/?seqid=P08622 ProteinModelPortal P08622 http://www.proteinmodelportal.org/query/uniprot/P08622 PubMed 10210198 http://www.ncbi.nlm.nih.gov/pubmed/10210198 PubMed 10891270 http://www.ncbi.nlm.nih.gov/pubmed/10891270 PubMed 12454054 http://www.ncbi.nlm.nih.gov/pubmed/12454054 PubMed 12941935 http://www.ncbi.nlm.nih.gov/pubmed/12941935 PubMed 14726952 http://www.ncbi.nlm.nih.gov/pubmed/14726952 PubMed 14729677 http://www.ncbi.nlm.nih.gov/pubmed/14729677 PubMed 15044009 http://www.ncbi.nlm.nih.gov/pubmed/15044009 PubMed 15302880 http://www.ncbi.nlm.nih.gov/pubmed/15302880 PubMed 15485812 http://www.ncbi.nlm.nih.gov/pubmed/15485812 PubMed 15683252 http://www.ncbi.nlm.nih.gov/pubmed/15683252 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1826368 http://www.ncbi.nlm.nih.gov/pubmed/1826368 PubMed 3003084 http://www.ncbi.nlm.nih.gov/pubmed/3003084 PubMed 3003085 http://www.ncbi.nlm.nih.gov/pubmed/3003085 PubMed 8106526 http://www.ncbi.nlm.nih.gov/pubmed/8106526 PubMed 8764403 http://www.ncbi.nlm.nih.gov/pubmed/8764403 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9860950 http://www.ncbi.nlm.nih.gov/pubmed/9860950 RefSeq NP_414556 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414556 RefSeq WP_001118476 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001118476 SMART SM00271 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00271 SMR P08622 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P08622 STRING 511145.b0015 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0015&targetmode=cogs STRING COG0484 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0484&targetmode=cogs SUPFAM SSF46565 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46565 SUPFAM SSF49493 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49493 SUPFAM SSF57938 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF57938 TIGRFAMs TIGR02349 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02349 UniProtKB DNAJ_ECOLI http://www.uniprot.org/uniprot/DNAJ_ECOLI UniProtKB-AC P08622 http://www.uniprot.org/uniprot/P08622 charge swissprot:DNAJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DNAJ_ECOLI eggNOG COG0484 http://eggnogapi.embl.de/nog_data/html/tree/COG0484 eggNOG ENOG4105BZ5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZ5 epestfind swissprot:DNAJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DNAJ_ECOLI garnier swissprot:DNAJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DNAJ_ECOLI helixturnhelix swissprot:DNAJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DNAJ_ECOLI hmoment swissprot:DNAJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DNAJ_ECOLI iep swissprot:DNAJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DNAJ_ECOLI inforesidue swissprot:DNAJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DNAJ_ECOLI octanol swissprot:DNAJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DNAJ_ECOLI pepcoil swissprot:DNAJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DNAJ_ECOLI pepdigest swissprot:DNAJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DNAJ_ECOLI pepinfo swissprot:DNAJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DNAJ_ECOLI pepnet swissprot:DNAJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DNAJ_ECOLI pepstats swissprot:DNAJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DNAJ_ECOLI pepwheel swissprot:DNAJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DNAJ_ECOLI pepwindow swissprot:DNAJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DNAJ_ECOLI sigcleave swissprot:DNAJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DNAJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4259570 130 # DISRUPTION PHENOTYPE Mutants show minor defects in the assembly of outer membrane proteins. {ECO:0000269|PubMed 17404237}. # EcoGene EG10952 bamE # FUNCTION BAME_ECOLI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Nonessential member of the complex that stabilizes the interaction between the essential proteins BamA and BamD. May modulate the conformation of BamA, likely through interactions with BamD. {ECO 0000255|HAMAP- Rule MF_00925, ECO 0000269|PubMed 17404237, ECO 0000269|PubMed 20378773, ECO 0000269|PubMed 21207987, ECO 0000269|PubMed 21586578, ECO 0000269|PubMed 21823654, ECO 0000269|PubMed 22178970}. # GO_component GO:0016020 membrane; IDA:EcoliWiki. # GO_component GO:0045203 integral component of cell outer membrane; IGI:EcoliWiki. # GO_function GO:0030674 protein binding, bridging; IPI:EcoCyc. # GO_function GO:0042802 identical protein binding; IPI:IntAct. # GO_process GO:0043165 Gram-negative-bacterium-type cell outer membrane assembly; IDA:EcoCyc. # GO_process GO:0046677 response to antibiotic; IMP:EcoCyc. # GO_process GO:0051205 protein insertion into membrane; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0030674 protein binding, bridging # GOslim_process GO:0008150 biological_process # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0061024 membrane organization # HAMAP MF_00925 OM_assembly_BamE # INTERACTION BAME_ECOLI Self; NbExp=14; IntAct=EBI-6391574, EBI-6391574; # IntAct P0A937 4 # InterPro IPR007450 Lipoprotein_SmpA/OmlA # InterPro IPR026592 BamE # Organism BAME_ECOLI Escherichia coli (strain K12) # PATRIC 32120633 VBIEscCol129921_2715 # PDB 2KM7 NMR; -; A=20-113 # PDB 2KXX NMR; -; A=21-113 # PDB 2YH9 X-ray; 1.80 A; A/B/C=34-113 # PDB 5AYW X-ray; 3.56 A; E=20-113 # PDB 5D0O X-ray; 2.90 A; E=1-113 # PDB 5D0Q X-ray; 3.50 A; E/I=1-113 # PDB 5EKQ X-ray; 3.39 A; E=20-113 # PIR S11646 S11646 # PIR T08630 T08630 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF04355 SmpA_OmlA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Outer membrane protein assembly factor BamE {ECO:0000255|HAMAP-Rule MF_00925} # RefSeq NP_417107 NC_000913.3 # RefSeq WP_001203437 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA36847.1; Type=Miscellaneous discrepancy; Note=Sequence of unknown provenance, it does not match this entry.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the BamE family. {ECO:0000255|HAMAP- Rule MF_00925}. # SUBCELLULAR LOCATION BAME_ECOLI Cell outer membrane {ECO 0000255|HAMAP- Rule MF_00925, ECO 0000269|PubMed 17404237}; Lipid-anchor {ECO 0000255|HAMAP-Rule MF_00925, ECO 0000269|PubMed 17404237}. # SUBUNIT BAME_ECOLI Part of the Bam complex, which is composed of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE. Forms a subcomplex with BamC and BamD. Monomer in the periplasm, but is able to adopt a dimeric conformation in the cytoplasm. {ECO 0000255|HAMAP-Rule MF_00925, ECO 0000269|PubMed 17404237, ECO 0000269|PubMed 20378773, ECO 0000269|PubMed 21139201, ECO 0000269|PubMed 21207987, ECO 0000269|PubMed 21212804, ECO 0000269|PubMed 21586578, ECO 0000269|PubMed 21823654}. # TCDB 1.B.33.1 the outer membrane protein insertion porin (bam complex) (ompip) family # eggNOG COG2913 LUCA # eggNOG ENOG4105YRI Bacteria BLAST swissprot:BAME_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BAME_ECOLI BioCyc ECOL316407:JW2598-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2598-MONOMER BioCyc EcoCyc:EG10952-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10952-MONOMER COG COG2913 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2913 DIP DIP-10895N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10895N DOI 10.1021/bi101659u http://dx.doi.org/10.1021/bi101659u DOI 10.1021/bi2010784 http://dx.doi.org/10.1021/bi2010784 DOI 10.1038/embor.2010.202 http://dx.doi.org/10.1038/embor.2010.202 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0701579104 http://dx.doi.org/10.1073/pnas.0701579104 DOI 10.1074/jbc.M111.238931 http://dx.doi.org/10.1074/jbc.M111.238931 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1107/S1744309110034160 http://dx.doi.org/10.1107/S1744309110034160 DOI 10.1126/science.1188919 http://dx.doi.org/10.1126/science.1188919 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.06426-11 http://dx.doi.org/10.1128/JB.06426-11 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36840 http://www.ebi.ac.uk/ena/data/view/U36840 EMBL X52620 http://www.ebi.ac.uk/ena/data/view/X52620 EchoBASE EB0945 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0945 EcoGene EG10952 http://www.ecogene.org/geneInfo.php?eg_id=EG10952 EnsemblBacteria AAC75666 http://www.ensemblgenomes.org/id/AAC75666 EnsemblBacteria AAC75666 http://www.ensemblgenomes.org/id/AAC75666 EnsemblBacteria BAA16502 http://www.ensemblgenomes.org/id/BAA16502 EnsemblBacteria BAA16502 http://www.ensemblgenomes.org/id/BAA16502 EnsemblBacteria BAA16502 http://www.ensemblgenomes.org/id/BAA16502 EnsemblBacteria b2617 http://www.ensemblgenomes.org/id/b2617 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0045203 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045203 GO_function GO:0030674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030674 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0043165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043165 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GO_process GO:0051205 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051205 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0030674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030674 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0061024 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024 GeneID 945583 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945583 HAMAP MF_00925 http://hamap.expasy.org/unirule/MF_00925 HOGENOM HOG000256181 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000256181&db=HOGENOM6 InParanoid P0A937 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A937 IntAct P0A937 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A937* InterPro IPR007450 http://www.ebi.ac.uk/interpro/entry/IPR007450 InterPro IPR026592 http://www.ebi.ac.uk/interpro/entry/IPR026592 KEGG_Gene ecj:JW2598 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2598 KEGG_Gene eco:b2617 http://www.genome.jp/dbget-bin/www_bget?eco:b2617 KEGG_Orthology KO:K06186 http://www.genome.jp/dbget-bin/www_bget?KO:K06186 MINT MINT-8141263 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8141263 OMA QPGHEKV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QPGHEKV PDB 2KM7 http://www.ebi.ac.uk/pdbe-srv/view/entry/2KM7 PDB 2KXX http://www.ebi.ac.uk/pdbe-srv/view/entry/2KXX PDB 2YH9 http://www.ebi.ac.uk/pdbe-srv/view/entry/2YH9 PDB 5AYW http://www.ebi.ac.uk/pdbe-srv/view/entry/5AYW PDB 5D0O http://www.ebi.ac.uk/pdbe-srv/view/entry/5D0O PDB 5D0Q http://www.ebi.ac.uk/pdbe-srv/view/entry/5D0Q PDB 5EKQ http://www.ebi.ac.uk/pdbe-srv/view/entry/5EKQ PDBsum 2KM7 http://www.ebi.ac.uk/pdbsum/2KM7 PDBsum 2KXX http://www.ebi.ac.uk/pdbsum/2KXX PDBsum 2YH9 http://www.ebi.ac.uk/pdbsum/2YH9 PDBsum 5AYW http://www.ebi.ac.uk/pdbsum/5AYW PDBsum 5D0O http://www.ebi.ac.uk/pdbsum/5D0O PDBsum 5D0Q http://www.ebi.ac.uk/pdbsum/5D0Q PDBsum 5EKQ http://www.ebi.ac.uk/pdbsum/5EKQ PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:BAME_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BAME_ECOLI PSORT-B swissprot:BAME_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BAME_ECOLI PSORT2 swissprot:BAME_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BAME_ECOLI Pfam PF04355 http://pfam.xfam.org/family/PF04355 Phobius swissprot:BAME_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BAME_ECOLI PhylomeDB P0A937 http://phylomedb.org/?seqid=P0A937 ProteinModelPortal P0A937 http://www.proteinmodelportal.org/query/uniprot/P0A937 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17404237 http://www.ncbi.nlm.nih.gov/pubmed/17404237 PubMed 20378773 http://www.ncbi.nlm.nih.gov/pubmed/20378773 PubMed 2045357 http://www.ncbi.nlm.nih.gov/pubmed/2045357 PubMed 21139201 http://www.ncbi.nlm.nih.gov/pubmed/21139201 PubMed 21207987 http://www.ncbi.nlm.nih.gov/pubmed/21207987 PubMed 21212804 http://www.ncbi.nlm.nih.gov/pubmed/21212804 PubMed 21586578 http://www.ncbi.nlm.nih.gov/pubmed/21586578 PubMed 21823654 http://www.ncbi.nlm.nih.gov/pubmed/21823654 PubMed 22178970 http://www.ncbi.nlm.nih.gov/pubmed/22178970 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417107 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417107 RefSeq WP_001203437 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001203437 SMR P0A937 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A937 STRING 511145.b2617 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2617&targetmode=cogs STRING COG2913 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2913&targetmode=cogs TCDB 1.B.33.1 http://www.tcdb.org/search/result.php?tc=1.B.33.1 UniProtKB BAME_ECOLI http://www.uniprot.org/uniprot/BAME_ECOLI UniProtKB-AC P0A937 http://www.uniprot.org/uniprot/P0A937 charge swissprot:BAME_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BAME_ECOLI eggNOG COG2913 http://eggnogapi.embl.de/nog_data/html/tree/COG2913 eggNOG ENOG4105YRI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105YRI epestfind swissprot:BAME_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BAME_ECOLI garnier swissprot:BAME_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BAME_ECOLI helixturnhelix swissprot:BAME_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BAME_ECOLI hmoment swissprot:BAME_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BAME_ECOLI iep swissprot:BAME_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BAME_ECOLI inforesidue swissprot:BAME_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BAME_ECOLI octanol swissprot:BAME_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BAME_ECOLI pepcoil swissprot:BAME_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BAME_ECOLI pepdigest swissprot:BAME_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BAME_ECOLI pepinfo swissprot:BAME_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BAME_ECOLI pepnet swissprot:BAME_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BAME_ECOLI pepstats swissprot:BAME_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BAME_ECOLI pepwheel swissprot:BAME_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BAME_ECOLI pepwindow swissprot:BAME_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BAME_ECOLI sigcleave swissprot:BAME_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BAME_ECOLI ## Database ID URL or Descriptions # BioGrid 4262698 178 # CAUTION SUGE_ECOLI Was originally (PubMed 8096175) thought to suppress a groEL mutation and mimic the effect of groE overexpression. This was later shown (PubMed 11948170) to be probably due to an artifact. {ECO 0000305|PubMed 11948170, ECO 0000305|PubMed 8096175}. # EcoGene EG11616 sugE # FUNCTION SUGE_ECOLI Quaternary ammonium compound efflux pump. Confers resistance to cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations. {ECO 0000269|PubMed 11948170}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0022891 substrate-specific transmembrane transporter activity; IBA:GO_Central. # GO_function GO:0090484 drug transporter activity; IMP:EcoCyc. # GO_process GO:0046618 drug export; IMP:EcoCyc. # GO_process GO:0055085 transmembrane transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # InterPro IPR000390 Small_multidrug_res # KEGG_Brite ko02000 Transporters # MISCELLANEOUS SUGE_ECOLI Unlike the other members of the SMR family, SugE exhibits a narrow specificity for a very specific class of compounds. # Organism SUGE_ECOLI Escherichia coli (strain K12) # PATRIC 32123869 VBIEscCol129921_4282 # PIR S56376 S56376 # Pfam PF00893 Multi_Drug_Res # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SUGE_ECOLI Quaternary ammonium compound-resistance protein SugE # RefSeq NP_418572 NC_000913.3 # RefSeq WP_000118482 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97047.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA49570.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the small multidrug resistance (SMR) protein family. SugE (TC 2.A.7.1.4) subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION SUGE_ECOLI Cell inner membrane {ECO 0000269|PubMed 14728684}; Multi-pass membrane protein {ECO 0000269|PubMed 14728684}. # TCDB 2.A.7.1 the drug/metabolite transporter (dmt) superfamily # eggNOG COG2076 LUCA # eggNOG ENOG4105KPY Bacteria BLAST swissprot:SUGE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SUGE_ECOLI BioCyc ECOL316407:JW5738-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5738-MONOMER BioCyc EcoCyc:SUGE-MONOMER http://biocyc.org/getid?id=EcoCyc:SUGE-MONOMER COG COG2076 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2076 DOI 10.1006/jmbi.1998.1894 http://dx.doi.org/10.1006/jmbi.1998.1894 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1111/j.1432-1033.2003.03959.x http://dx.doi.org/10.1111/j.1432-1033.2003.03959.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.9.2543-2545.2002 http://dx.doi.org/10.1128/JB.184.9.2543-2545.2002 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL U21726 http://www.ebi.ac.uk/ena/data/view/U21726 EMBL X69949 http://www.ebi.ac.uk/ena/data/view/X69949 EMBL X69949 http://www.ebi.ac.uk/ena/data/view/X69949 EchoBASE EB1573 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1573 EcoGene EG11616 http://www.ecogene.org/geneInfo.php?eg_id=EG11616 EnsemblBacteria AAC77108 http://www.ensemblgenomes.org/id/AAC77108 EnsemblBacteria AAC77108 http://www.ensemblgenomes.org/id/AAC77108 EnsemblBacteria BAE78152 http://www.ensemblgenomes.org/id/BAE78152 EnsemblBacteria BAE78152 http://www.ensemblgenomes.org/id/BAE78152 EnsemblBacteria BAE78152 http://www.ensemblgenomes.org/id/BAE78152 EnsemblBacteria b4148 http://www.ensemblgenomes.org/id/b4148 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0022891 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022891 GO_function GO:0090484 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090484 GO_process GO:0046618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046618 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 948671 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948671 HOGENOM HOG000268007 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000268007&db=HOGENOM6 InParanoid P69937 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P69937 InterPro IPR000390 http://www.ebi.ac.uk/interpro/entry/IPR000390 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5738 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5738 KEGG_Gene eco:b4148 http://www.genome.jp/dbget-bin/www_bget?eco:b4148 KEGG_Orthology KO:K11741 http://www.genome.jp/dbget-bin/www_bget?KO:K11741 OMA LEVGWAI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LEVGWAI PSORT swissprot:SUGE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SUGE_ECOLI PSORT-B swissprot:SUGE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SUGE_ECOLI PSORT2 swissprot:SUGE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SUGE_ECOLI Pfam PF00893 http://pfam.xfam.org/family/PF00893 Phobius swissprot:SUGE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SUGE_ECOLI PhylomeDB P69937 http://phylomedb.org/?seqid=P69937 ProteinModelPortal P69937 http://www.proteinmodelportal.org/query/uniprot/P69937 PubMed 11948170 http://www.ncbi.nlm.nih.gov/pubmed/11948170 PubMed 14728684 http://www.ncbi.nlm.nih.gov/pubmed/14728684 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8096175 http://www.ncbi.nlm.nih.gov/pubmed/8096175 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9677290 http://www.ncbi.nlm.nih.gov/pubmed/9677290 RefSeq NP_418572 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418572 RefSeq WP_000118482 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000118482 SMR P69937 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69937 STRING 511145.b4148 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4148&targetmode=cogs STRING COG2076 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2076&targetmode=cogs TCDB 2.A.7.1 http://www.tcdb.org/search/result.php?tc=2.A.7.1 UniProtKB SUGE_ECOLI http://www.uniprot.org/uniprot/SUGE_ECOLI UniProtKB-AC P69937 http://www.uniprot.org/uniprot/P69937 charge swissprot:SUGE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SUGE_ECOLI eggNOG COG2076 http://eggnogapi.embl.de/nog_data/html/tree/COG2076 eggNOG ENOG4105KPY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KPY epestfind swissprot:SUGE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SUGE_ECOLI garnier swissprot:SUGE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SUGE_ECOLI helixturnhelix swissprot:SUGE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SUGE_ECOLI hmoment swissprot:SUGE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SUGE_ECOLI iep swissprot:SUGE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SUGE_ECOLI inforesidue swissprot:SUGE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SUGE_ECOLI octanol swissprot:SUGE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SUGE_ECOLI pepcoil swissprot:SUGE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SUGE_ECOLI pepdigest swissprot:SUGE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SUGE_ECOLI pepinfo swissprot:SUGE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SUGE_ECOLI pepnet swissprot:SUGE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SUGE_ECOLI pepstats swissprot:SUGE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SUGE_ECOLI pepwheel swissprot:SUGE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SUGE_ECOLI pepwindow swissprot:SUGE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SUGE_ECOLI sigcleave swissprot:SUGE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SUGE_ECOLI ## Database ID URL or Descriptions # BioGrid 4260446 7 # EcoGene EG14426 yohO # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # HAMAP MF_01362 UPF0387 # INDUCTION YOHO_ECOLI Constitutively expressed (at protein level). {ECO 0000269|PubMed 19121005, ECO 0000269|PubMed 19734316}. # InterPro IPR020870 UPF0387_membrane # Organism YOHO_ECOLI Escherichia coli (strain K12) # PATRIC 32119593 VBIEscCol129921_2207 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UPF0387 membrane protein YohO {ECO:0000255|HAMAP-Rule MF_01362} # RefSeq WP_001216963 NZ_LN832404.1 # RefSeq YP_588460 NC_000913.3 # SIMILARITY Belongs to the UPF0387 family. {ECO:0000255|HAMAP- Rule MF_01362}. # SUBCELLULAR LOCATION YOHO_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01362}; Single-pass membrane protein {ECO 0000255|HAMAP- Rule MF_01362}. BLAST swissprot:YOHO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YOHO_ECOLI BioCyc ECOL316407:JW5354-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5354-MONOMER BioCyc EcoCyc:MONOMER0-2681 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2681 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2008.06495.x http://dx.doi.org/10.1111/j.1365-2958.2008.06495.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00872-09 http://dx.doi.org/10.1128/JB.00872-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14426 http://www.ecogene.org/geneInfo.php?eg_id=EG14426 EnsemblBacteria ABD18688 http://www.ensemblgenomes.org/id/ABD18688 EnsemblBacteria ABD18688 http://www.ensemblgenomes.org/id/ABD18688 EnsemblBacteria BAE76604 http://www.ensemblgenomes.org/id/BAE76604 EnsemblBacteria BAE76604 http://www.ensemblgenomes.org/id/BAE76604 EnsemblBacteria BAE76604 http://www.ensemblgenomes.org/id/BAE76604 EnsemblBacteria b4542 http://www.ensemblgenomes.org/id/b4542 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 1450279 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1450279 HAMAP MF_01362 http://hamap.expasy.org/unirule/MF_01362 HOGENOM HOG000267977 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267977&db=HOGENOM6 InterPro IPR020870 http://www.ebi.ac.uk/interpro/entry/IPR020870 KEGG_Gene ecj:JW5354 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5354 KEGG_Gene eco:b4542 http://www.genome.jp/dbget-bin/www_bget?eco:b4542 PSORT swissprot:YOHO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YOHO_ECOLI PSORT-B swissprot:YOHO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YOHO_ECOLI PSORT2 swissprot:YOHO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YOHO_ECOLI Phobius swissprot:YOHO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YOHO_ECOLI PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19121005 http://www.ncbi.nlm.nih.gov/pubmed/19121005 PubMed 19734316 http://www.ncbi.nlm.nih.gov/pubmed/19734316 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001216963 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001216963 RefSeq YP_588460 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_588460 STRING 511145.b4542 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4542&targetmode=cogs UniProtKB YOHO_ECOLI http://www.uniprot.org/uniprot/YOHO_ECOLI UniProtKB-AC Q2EES6 http://www.uniprot.org/uniprot/Q2EES6 charge swissprot:YOHO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YOHO_ECOLI epestfind swissprot:YOHO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YOHO_ECOLI garnier swissprot:YOHO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YOHO_ECOLI helixturnhelix swissprot:YOHO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YOHO_ECOLI hmoment swissprot:YOHO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YOHO_ECOLI iep swissprot:YOHO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YOHO_ECOLI inforesidue swissprot:YOHO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YOHO_ECOLI octanol swissprot:YOHO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YOHO_ECOLI pepcoil swissprot:YOHO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YOHO_ECOLI pepdigest swissprot:YOHO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YOHO_ECOLI pepinfo swissprot:YOHO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YOHO_ECOLI pepnet swissprot:YOHO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YOHO_ECOLI pepstats swissprot:YOHO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YOHO_ECOLI pepwheel swissprot:YOHO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YOHO_ECOLI pepwindow swissprot:YOHO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YOHO_ECOLI sigcleave swissprot:YOHO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YOHO_ECOLI ## Database ID URL or Descriptions # BioGrid 4262783 126 # CDD cd06170 LuxR_C_like # EcoGene EG12594 bglJ # FUNCTION BGLJ_ECOLI A crytic transcriptional activator. When its expression is induced it relieves H-NS repression of the bgl operon. Acts independently of transcription factor LeuO. {ECO 0000269|PubMed 8725214}. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # INDUCTION BGLJ_ECOLI Repressed by H-NS, activated by LeuO. Member of the yjjQ-bglJ operon. {ECO 0000269|PubMed 18055596, ECO 0000269|PubMed 19429622}. # INTERACTION BGLJ_ECOLI P0DMC7 rcsB; NbExp=2; IntAct=EBI-551429, EBI-369670; # IntAct P39404 2 # InterPro IPR000792 Tscrpt_reg_LuxR_C # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR016032 Sig_transdc_resp-reg_C-effctor # Organism BGLJ_ECOLI Escherichia coli (strain K12) # PATRIC 32124340 VBIEscCol129921_4513 # PRINTS PR00038 HTHLUXR # PROSITE PS50043 HTH_LUXR_2 # Pfam PF00196 GerE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BGLJ_ECOLI Transcriptional activator protein BglJ # RefSeq NP_418786 NC_000913.3 # RefSeq WP_001301727 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=BAE78356.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Contains 1 HTH luxR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00411}. # SMART SM00421 HTH_LUXR # SUBUNIT BGLJ_ECOLI Forms a complex with RcsB; genetically both BglJ and RcsB are required to relieve bgl operon repression by H-NS and by StpA. # SUPFAM SSF46894 SSF46894 # eggNOG COG2197 LUCA # eggNOG ENOG4108T94 Bacteria BLAST swissprot:BGLJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BGLJ_ECOLI BioCyc ECOL316407:JW5955-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5955-MONOMER BioCyc EcoCyc:G7948-MONOMER http://biocyc.org/getid?id=EcoCyc:G7948-MONOMER DIP DIP-9217N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9217N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00108-09 http://dx.doi.org/10.1128/JB.00108-09 DOI 10.1128/JB.00807-10 http://dx.doi.org/10.1128/JB.00807-10 DOI 10.1128/JB.01447-07 http://dx.doi.org/10.1128/JB.01447-07 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL U35834 http://www.ebi.ac.uk/ena/data/view/U35834 EchoBASE EB2479 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2479 EcoGene EG12594 http://www.ecogene.org/geneInfo.php?eg_id=EG12594 EnsemblBacteria AAC77322 http://www.ensemblgenomes.org/id/AAC77322 EnsemblBacteria AAC77322 http://www.ensemblgenomes.org/id/AAC77322 EnsemblBacteria BAE78356 http://www.ensemblgenomes.org/id/BAE78356 EnsemblBacteria BAE78356 http://www.ensemblgenomes.org/id/BAE78356 EnsemblBacteria BAE78356 http://www.ensemblgenomes.org/id/BAE78356 EnsemblBacteria b4366 http://www.ensemblgenomes.org/id/b4366 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 948889 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948889 HOGENOM HOG000127596 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000127596&db=HOGENOM6 IntAct P39404 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39404* InterPro IPR000792 http://www.ebi.ac.uk/interpro/entry/IPR000792 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR016032 http://www.ebi.ac.uk/interpro/entry/IPR016032 KEGG_Gene ecj:JW5955 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5955 KEGG_Gene eco:b4366 http://www.genome.jp/dbget-bin/www_bget?eco:b4366 MINT MINT-1268192 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1268192 PRINTS PR00038 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00038 PROSITE PS50043 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50043 PSORT swissprot:BGLJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BGLJ_ECOLI PSORT-B swissprot:BGLJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BGLJ_ECOLI PSORT2 swissprot:BGLJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BGLJ_ECOLI Pfam PF00196 http://pfam.xfam.org/family/PF00196 Phobius swissprot:BGLJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BGLJ_ECOLI ProteinModelPortal P39404 http://www.proteinmodelportal.org/query/uniprot/P39404 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18055596 http://www.ncbi.nlm.nih.gov/pubmed/18055596 PubMed 19429622 http://www.ncbi.nlm.nih.gov/pubmed/19429622 PubMed 20952573 http://www.ncbi.nlm.nih.gov/pubmed/20952573 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8725214 http://www.ncbi.nlm.nih.gov/pubmed/8725214 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418786 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418786 RefSeq WP_001301727 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001301727 SMART SM00421 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00421 SMR P39404 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39404 STRING 511145.b4366 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4366&targetmode=cogs SUPFAM SSF46894 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46894 UniProtKB BGLJ_ECOLI http://www.uniprot.org/uniprot/BGLJ_ECOLI UniProtKB-AC P39404 http://www.uniprot.org/uniprot/P39404 charge swissprot:BGLJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BGLJ_ECOLI eggNOG COG2197 http://eggnogapi.embl.de/nog_data/html/tree/COG2197 eggNOG ENOG4108T94 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108T94 epestfind swissprot:BGLJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BGLJ_ECOLI garnier swissprot:BGLJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BGLJ_ECOLI helixturnhelix swissprot:BGLJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BGLJ_ECOLI hmoment swissprot:BGLJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BGLJ_ECOLI iep swissprot:BGLJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BGLJ_ECOLI inforesidue swissprot:BGLJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BGLJ_ECOLI octanol swissprot:BGLJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BGLJ_ECOLI pepcoil swissprot:BGLJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BGLJ_ECOLI pepdigest swissprot:BGLJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BGLJ_ECOLI pepinfo swissprot:BGLJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BGLJ_ECOLI pepnet swissprot:BGLJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BGLJ_ECOLI pepstats swissprot:BGLJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BGLJ_ECOLI pepwheel swissprot:BGLJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BGLJ_ECOLI pepwindow swissprot:BGLJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BGLJ_ECOLI sigcleave swissprot:BGLJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BGLJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4262409 7 # CDD cd06174 MFS # EcoGene EG12738 exuT # FUNCTION EXUT_ECOLI Aldohexuronate transport system. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IBA:GO_Central. # GO_function GO:0015134 hexuronate transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0015736 hexuronate transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # INDUCTION Repressed by H-NS. {ECO:0000269|PubMed 19429622}. # InterPro IPR004744 Dgal_transporter # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # KEGG_Brite ko02000 Transporters # Organism EXUT_ECOLI Escherichia coli (strain K12) # PATRIC 32121604 VBIEscCol129921_3188 # PIR B65098 B65098 # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EXUT_ECOLI Hexuronate transporter # RefSeq NP_417564 NC_000913.3 # RefSeq WP_001226465 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA57897.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA02588.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=BAE77143.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; # SIMILARITY Belongs to the major facilitator superfamily. Phthalate permease family. {ECO 0000305}. # SUBCELLULAR LOCATION EXUT_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.14 the major facilitator superfamily (mfs) # TIGRFAMs TIGR00893 2A0114 # eggNOG ENOG4105DPW Bacteria # eggNOG ENOG410ZVFJ LUCA BLAST swissprot:EXUT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EXUT_ECOLI BioCyc ECOL316407:JW3064-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3064-MONOMER BioCyc EcoCyc:EXUT-MONOMER http://biocyc.org/getid?id=EcoCyc:EXUT-MONOMER BioCyc MetaCyc:EXUT-MONOMER http://biocyc.org/getid?id=MetaCyc:EXUT-MONOMER COG COG0477 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0477 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00108-09 http://dx.doi.org/10.1128/JB.00108-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D13328 http://www.ebi.ac.uk/ena/data/view/D13328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2594 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2594 EcoGene EG12738 http://www.ecogene.org/geneInfo.php?eg_id=EG12738 EnsemblBacteria AAC76128 http://www.ensemblgenomes.org/id/AAC76128 EnsemblBacteria AAC76128 http://www.ensemblgenomes.org/id/AAC76128 EnsemblBacteria BAE77143 http://www.ensemblgenomes.org/id/BAE77143 EnsemblBacteria BAE77143 http://www.ensemblgenomes.org/id/BAE77143 EnsemblBacteria BAE77143 http://www.ensemblgenomes.org/id/BAE77143 EnsemblBacteria b3093 http://www.ensemblgenomes.org/id/b3093 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015134 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015134 GO_process GO:0015736 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015736 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 947601 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947601 HOGENOM HOG000113643 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000113643&db=HOGENOM6 InParanoid P0AA78 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AA78 InterPro IPR004744 http://www.ebi.ac.uk/interpro/entry/IPR004744 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3064 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3064 KEGG_Gene eco:b3093 http://www.genome.jp/dbget-bin/www_bget?eco:b3093 KEGG_Orthology KO:K08191 http://www.genome.jp/dbget-bin/www_bget?KO:K08191 PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:EXUT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EXUT_ECOLI PSORT-B swissprot:EXUT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EXUT_ECOLI PSORT2 swissprot:EXUT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EXUT_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:EXUT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EXUT_ECOLI ProteinModelPortal P0AA78 http://www.proteinmodelportal.org/query/uniprot/P0AA78 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19429622 http://www.ncbi.nlm.nih.gov/pubmed/19429622 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417564 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417564 RefSeq WP_001226465 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001226465 STRING 511145.b3093 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3093&targetmode=cogs STRING COG0477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0477&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.14 http://www.tcdb.org/search/result.php?tc=2.A.1.14 TIGRFAMs TIGR00893 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00893 UniProtKB EXUT_ECOLI http://www.uniprot.org/uniprot/EXUT_ECOLI UniProtKB-AC P0AA78 http://www.uniprot.org/uniprot/P0AA78 charge swissprot:EXUT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EXUT_ECOLI eggNOG ENOG4105DPW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DPW eggNOG ENOG410ZVFJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZVFJ epestfind swissprot:EXUT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EXUT_ECOLI garnier swissprot:EXUT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EXUT_ECOLI helixturnhelix swissprot:EXUT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EXUT_ECOLI hmoment swissprot:EXUT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EXUT_ECOLI iep swissprot:EXUT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EXUT_ECOLI inforesidue swissprot:EXUT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EXUT_ECOLI octanol swissprot:EXUT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EXUT_ECOLI pepcoil swissprot:EXUT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EXUT_ECOLI pepdigest swissprot:EXUT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EXUT_ECOLI pepinfo swissprot:EXUT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EXUT_ECOLI pepnet swissprot:EXUT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EXUT_ECOLI pepstats swissprot:EXUT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EXUT_ECOLI pepwheel swissprot:EXUT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EXUT_ECOLI pepwindow swissprot:EXUT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EXUT_ECOLI sigcleave swissprot:EXUT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EXUT_ECOLI ## Database ID URL or Descriptions # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # CDD cd00342 gram_neg_porins # EcoGene EG14042 yedS # GO_component GO:0009279 cell outer membrane; IEA:UniProtKB-SubCell. # GO_component GO:0046930 pore complex; IEA:UniProtKB-KW. # GO_function GO:0015288 porin activity; IEA:UniProtKB-KW. # GO_process GO:0006811 ion transport; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043234 protein complex # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # Gene3D 2.40.160.10 -; 1. # INTERACTION YEDS_ECOLI P0ACL5 glcC; NbExp=2; IntAct=EBI-1119674, EBI-1115389; # IntAct P76335 5 # InterPro IPR001702 Porin_Gram-ve # InterPro IPR001897 Porin_gammaproteobac # InterPro IPR013793 Porin_Gram-ve_CS # InterPro IPR023614 Porin_dom # InterPro IPR033900 Gram_neg_porin_domain # Organism YEDS_ECOLI Escherichia coli (strain K12) # PRINTS PR00182 ECOLNEIPORIN # PRINTS PR00183 ECOLIPORIN # PROSITE PS00576 GRAM_NEG_PORIN # Pfam PF00267 Porin_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEDS_ECOLI Putative outer membrane protein YedS # SEQUENCE CAUTION YEDS_ECOLI Sequence=AP009048; Type=Erroneous termination; Positions=162; Note=Translated as Leu.; Evidence={ECO 0000305}; Sequence=AP009048; Type=Frameshift; Positions=Several; Evidence={ECO 0000305}; Sequence=U00096; Type=Erroneous termination; Positions=162; Note=Translated as Leu.; Evidence={ECO 0000305}; Sequence=U00096; Type=Frameshift; Positions=Several; Evidence={ECO 0000305}; # SIMILARITY Belongs to the Gram-negative porin family. {ECO 0000305}. # SUBCELLULAR LOCATION YEDS_ECOLI Cell outer membrane {ECO 0000250}; Multi- pass membrane protein {ECO 0000250}. # SUBUNIT Homotrimer. {ECO 0000250}. BLAST swissprot:YEDS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEDS_ECOLI BioCyc EcoCyc:G7052-MONOMER http://biocyc.org/getid?id=EcoCyc:G7052-MONOMER BioCyc EcoCyc:G7053-MONOMER http://biocyc.org/getid?id=EcoCyc:G7053-MONOMER BioCyc EcoCyc:G7054-MONOMER http://biocyc.org/getid?id=EcoCyc:G7054-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3796 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3796 EcoGene EG14042 http://www.ecogene.org/geneInfo.php?eg_id=EG14042 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0046930 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046930 GO_function GO:0015288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015288 GO_process GO:0006811 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 2.40.160.10 http://www.cathdb.info/version/latest/superfamily/2.40.160.10 HOGENOM HOG000272406 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000272406&db=HOGENOM6 InParanoid P76335 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76335 IntAct P76335 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76335* InterPro IPR001702 http://www.ebi.ac.uk/interpro/entry/IPR001702 InterPro IPR001897 http://www.ebi.ac.uk/interpro/entry/IPR001897 InterPro IPR013793 http://www.ebi.ac.uk/interpro/entry/IPR013793 InterPro IPR023614 http://www.ebi.ac.uk/interpro/entry/IPR023614 InterPro IPR033900 http://www.ebi.ac.uk/interpro/entry/IPR033900 PRINTS PR00182 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00182 PRINTS PR00183 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00183 PROSITE PS00576 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00576 PSORT swissprot:YEDS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEDS_ECOLI PSORT-B swissprot:YEDS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEDS_ECOLI PSORT2 swissprot:YEDS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEDS_ECOLI Pfam PF00267 http://pfam.xfam.org/family/PF00267 Phobius swissprot:YEDS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEDS_ECOLI PhylomeDB P76335 http://phylomedb.org/?seqid=P76335 ProteinModelPortal P76335 http://www.proteinmodelportal.org/query/uniprot/P76335 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 UniProtKB YEDS_ECOLI http://www.uniprot.org/uniprot/YEDS_ECOLI UniProtKB-AC P76335 http://www.uniprot.org/uniprot/P76335 charge swissprot:YEDS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEDS_ECOLI epestfind swissprot:YEDS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEDS_ECOLI garnier swissprot:YEDS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEDS_ECOLI helixturnhelix swissprot:YEDS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEDS_ECOLI hmoment swissprot:YEDS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEDS_ECOLI iep swissprot:YEDS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEDS_ECOLI inforesidue swissprot:YEDS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEDS_ECOLI octanol swissprot:YEDS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEDS_ECOLI pepcoil swissprot:YEDS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEDS_ECOLI pepdigest swissprot:YEDS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEDS_ECOLI pepinfo swissprot:YEDS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEDS_ECOLI pepnet swissprot:YEDS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEDS_ECOLI pepstats swissprot:YEDS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEDS_ECOLI pepwheel swissprot:YEDS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEDS_ECOLI pepwindow swissprot:YEDS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEDS_ECOLI sigcleave swissprot:YEDS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEDS_ECOLI ## Database ID URL or Descriptions # BioGrid 4262836 21 # EcoGene EG12306 yccF # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function YCCF_ECOLI GO 0015369 calcium proton antiporter activity; IBA GO_Central. # GO_process GO:0006874 cellular calcium ion homeostasis; IBA:GO_Central. # GO_process GO:0070588 calcium ion transmembrane transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0042592 homeostatic process # GOslim_process GO:0055085 transmembrane transport # InterPro IPR005185 YccF # InterPro IPR031308 UCP028777 # Organism YCCF_ECOLI Escherichia coli (strain K12) # PATRIC 32117141 VBIEscCol129921_0995 # PIR H64836 H64836 # PIRSF PIRSF028777 UCP028777 # Pfam PF03733 YccF; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCCF_ECOLI Inner membrane protein YccF # RefSeq NP_415481 NC_000913.3 # RefSeq WP_001261235 NZ_LN832404.1 # SUBCELLULAR LOCATION YCCF_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 9.B.55.1 the 4 tms duf307/yccf (duf307) family # eggNOG COG3304 LUCA # eggNOG ENOG410901E Bacteria BLAST swissprot:YCCF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCCF_ECOLI BioCyc ECOL316407:JW0944-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0944-MONOMER BioCyc EcoCyc:G6496-MONOMER http://biocyc.org/getid?id=EcoCyc:G6496-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J04726 http://www.ebi.ac.uk/ena/data/view/J04726 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2212 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2212 EcoGene EG12306 http://www.ecogene.org/geneInfo.php?eg_id=EG12306 EnsemblBacteria AAC74047 http://www.ensemblgenomes.org/id/AAC74047 EnsemblBacteria AAC74047 http://www.ensemblgenomes.org/id/AAC74047 EnsemblBacteria BAA35719 http://www.ensemblgenomes.org/id/BAA35719 EnsemblBacteria BAA35719 http://www.ensemblgenomes.org/id/BAA35719 EnsemblBacteria BAA35719 http://www.ensemblgenomes.org/id/BAA35719 EnsemblBacteria b0961 http://www.ensemblgenomes.org/id/b0961 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015369 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015369 GO_process GO:0006874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006874 GO_process GO:0070588 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070588 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 945594 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945594 HOGENOM HOG000251868 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000251868&db=HOGENOM6 InParanoid P0AB12 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AB12 InterPro IPR005185 http://www.ebi.ac.uk/interpro/entry/IPR005185 InterPro IPR031308 http://www.ebi.ac.uk/interpro/entry/IPR031308 KEGG_Gene ecj:JW0944 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0944 KEGG_Gene eco:b0961 http://www.genome.jp/dbget-bin/www_bget?eco:b0961 OMA FGLQCFK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FGLQCFK PSORT swissprot:YCCF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCCF_ECOLI PSORT-B swissprot:YCCF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCCF_ECOLI PSORT2 swissprot:YCCF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCCF_ECOLI Pfam PF03733 http://pfam.xfam.org/family/PF03733 Phobius swissprot:YCCF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCCF_ECOLI PhylomeDB P0AB12 http://phylomedb.org/?seqid=P0AB12 ProteinModelPortal P0AB12 http://www.proteinmodelportal.org/query/uniprot/P0AB12 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2542273 http://www.ncbi.nlm.nih.gov/pubmed/2542273 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415481 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415481 RefSeq WP_001261235 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001261235 STRING 511145.b0961 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0961&targetmode=cogs TCDB 9.B.55.1 http://www.tcdb.org/search/result.php?tc=9.B.55.1 UniProtKB YCCF_ECOLI http://www.uniprot.org/uniprot/YCCF_ECOLI UniProtKB-AC P0AB12 http://www.uniprot.org/uniprot/P0AB12 charge swissprot:YCCF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCCF_ECOLI eggNOG COG3304 http://eggnogapi.embl.de/nog_data/html/tree/COG3304 eggNOG ENOG410901E http://eggnogapi.embl.de/nog_data/html/tree/ENOG410901E epestfind swissprot:YCCF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCCF_ECOLI garnier swissprot:YCCF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCCF_ECOLI helixturnhelix swissprot:YCCF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCCF_ECOLI hmoment swissprot:YCCF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCCF_ECOLI iep swissprot:YCCF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCCF_ECOLI inforesidue swissprot:YCCF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCCF_ECOLI octanol swissprot:YCCF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCCF_ECOLI pepcoil swissprot:YCCF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCCF_ECOLI pepdigest swissprot:YCCF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCCF_ECOLI pepinfo swissprot:YCCF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCCF_ECOLI pepnet swissprot:YCCF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCCF_ECOLI pepstats swissprot:YCCF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCCF_ECOLI pepwheel swissprot:YCCF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCCF_ECOLI pepwindow swissprot:YCCF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCCF_ECOLI sigcleave swissprot:YCCF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCCF_ECOLI ## Database ID URL or Descriptions # AltName PPIC_ECOLI Par10 # AltName PPIC_ECOLI Parvulin # AltName PPIC_ECOLI Rotamase C # BRENDA 5.2.1 2026 # BioGrid 4263314 199 # CATALYTIC ACTIVITY PPIC_ECOLI Peptidylproline (omega=180) = peptidylproline (omega=0). # EcoGene EG12352 ppiC # FUNCTION PPIC_ECOLI PPIases accelerate the folding of proteins. It prefers amino acid residues with hydrophobic side chains like leucine and phenylalanine in the P1 position of the peptides substrates. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003755 peptidyl-prolyl cis-trans isomerase activity; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016853 isomerase activity # IntAct P0A9L5 13 # InterPro IPR000297 PPIase_PpiC # InterPro IPR023058 PPIase_PpiC_CS # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03110 Chaperones and folding catalysts # Organism PPIC_ECOLI Escherichia coli (strain K12) # PATRIC 32123045 VBIEscCol129921_3892 # PDB 1JNS NMR; -; A=2-93 # PDB 1JNT NMR; -; A=2-93 # PIR S48658 S48658 # PROSITE PS01096 PPIC_PPIASE_1 # PROSITE PS50198 PPIC_PPIASE_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PPIC_ECOLI Peptidyl-prolyl cis-trans isomerase C # RefSeq NP_418223 NC_000913.3 # RefSeq WP_001140251 NZ_LN832404.1 # SIMILARITY Belongs to the PpiC/parvulin rotamase family. {ECO 0000305}. # SIMILARITY Contains 1 PpiC domain. {ECO:0000255|PROSITE- ProRule PRU00278}. # SUBCELLULAR LOCATION PPIC_ECOLI Cytoplasm. # eggNOG COG0760 LUCA # eggNOG ENOG4105KQ5 Bacteria BLAST swissprot:PPIC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PPIC_ECOLI BioCyc ECOL316407:JW3748-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3748-MONOMER BioCyc EcoCyc:EG12352-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12352-MONOMER BioCyc MetaCyc:EG12352-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12352-MONOMER COG COG0760 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0760 DIP DIP-48081N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48081N DOI 10.1016/0014-5793(94)00932-5 http://dx.doi.org/10.1016/0014-5793(94)00932-5 DOI 10.1016/0014-5793(94)80608-X http://dx.doi.org/10.1016/0014-5793(94)80608-X DOI 10.1016/S0968-0004(00)88941-0 http://dx.doi.org/10.1016/S0968-0004(00)88941-0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1110/ps.04756704 http://dx.doi.org/10.1110/ps.04756704 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.2.1.8 http://www.genome.jp/dbget-bin/www_bget?EC:5.2.1.8 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL S73874 http://www.ebi.ac.uk/ena/data/view/S73874 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 5.2.1.8 http://enzyme.expasy.org/EC/5.2.1.8 EchoBASE EB2256 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2256 EcoGene EG12352 http://www.ecogene.org/geneInfo.php?eg_id=EG12352 EnsemblBacteria AAC76780 http://www.ensemblgenomes.org/id/AAC76780 EnsemblBacteria AAC76780 http://www.ensemblgenomes.org/id/AAC76780 EnsemblBacteria BAE77522 http://www.ensemblgenomes.org/id/BAE77522 EnsemblBacteria BAE77522 http://www.ensemblgenomes.org/id/BAE77522 EnsemblBacteria BAE77522 http://www.ensemblgenomes.org/id/BAE77522 EnsemblBacteria b3775 http://www.ensemblgenomes.org/id/b3775 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003755 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003755 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GeneID 948285 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948285 HOGENOM HOG000275329 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275329&db=HOGENOM6 InParanoid P0A9L5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9L5 IntAct P0A9L5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9L5* IntEnz 5.2.1.8 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.2.1.8 InterPro IPR000297 http://www.ebi.ac.uk/interpro/entry/IPR000297 InterPro IPR023058 http://www.ebi.ac.uk/interpro/entry/IPR023058 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW3748 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3748 KEGG_Gene eco:b3775 http://www.genome.jp/dbget-bin/www_bget?eco:b3775 KEGG_Orthology KO:K03769 http://www.genome.jp/dbget-bin/www_bget?KO:K03769 MINT MINT-1225694 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1225694 OMA GYHLIEI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GYHLIEI PDB 1JNS http://www.ebi.ac.uk/pdbe-srv/view/entry/1JNS PDB 1JNT http://www.ebi.ac.uk/pdbe-srv/view/entry/1JNT PDBsum 1JNS http://www.ebi.ac.uk/pdbsum/1JNS PDBsum 1JNT http://www.ebi.ac.uk/pdbsum/1JNT PROSITE PS01096 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01096 PROSITE PS50198 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50198 PSORT swissprot:PPIC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PPIC_ECOLI PSORT-B swissprot:PPIC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PPIC_ECOLI PSORT2 swissprot:PPIC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PPIC_ECOLI Phobius swissprot:PPIC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PPIC_ECOLI PhylomeDB P0A9L5 http://phylomedb.org/?seqid=P0A9L5 ProteinModelPortal P0A9L5 http://www.proteinmodelportal.org/query/uniprot/P0A9L5 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 15322281 http://www.ncbi.nlm.nih.gov/pubmed/15322281 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7878732 http://www.ncbi.nlm.nih.gov/pubmed/7878732 PubMed 7925971 http://www.ncbi.nlm.nih.gov/pubmed/7925971 PubMed 8163020 http://www.ncbi.nlm.nih.gov/pubmed/8163020 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418223 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418223 RefSeq WP_001140251 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001140251 SMR P0A9L5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9L5 STRING 511145.b3775 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3775&targetmode=cogs STRING COG0760 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0760&targetmode=cogs UniProtKB PPIC_ECOLI http://www.uniprot.org/uniprot/PPIC_ECOLI UniProtKB-AC P0A9L5 http://www.uniprot.org/uniprot/P0A9L5 charge swissprot:PPIC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PPIC_ECOLI eggNOG COG0760 http://eggnogapi.embl.de/nog_data/html/tree/COG0760 eggNOG ENOG4105KQ5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KQ5 epestfind swissprot:PPIC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PPIC_ECOLI garnier swissprot:PPIC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PPIC_ECOLI helixturnhelix swissprot:PPIC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PPIC_ECOLI hmoment swissprot:PPIC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PPIC_ECOLI iep swissprot:PPIC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PPIC_ECOLI inforesidue swissprot:PPIC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PPIC_ECOLI octanol swissprot:PPIC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PPIC_ECOLI pepcoil swissprot:PPIC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PPIC_ECOLI pepdigest swissprot:PPIC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PPIC_ECOLI pepinfo swissprot:PPIC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PPIC_ECOLI pepnet swissprot:PPIC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PPIC_ECOLI pepstats swissprot:PPIC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PPIC_ECOLI pepwheel swissprot:PPIC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PPIC_ECOLI pepwindow swissprot:PPIC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PPIC_ECOLI sigcleave swissprot:PPIC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PPIC_ECOLI ## Database ID URL or Descriptions # BioGrid 4263088 7 # EcoGene EG10711 yjdM # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # IntAct P0AFJ1 2 # InterPro IPR004624 PhnA # InterPro IPR013987 PhnA_N # InterPro IPR013988 PhnA_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00440 Phosphonate and phosphinate metabolism # Organism PHNA_ECOLI Escherichia coli (strain K12) # PATRIC 32123781 VBIEscCol129921_4239 # PIR B35718 B35718 # Pfam PF03831 PhnA # Pfam PF08274 PhnA_Zn_Ribbon # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PHNA_ECOLI Protein PhnA # RefSeq NP_418532 NC_000913.3 # RefSeq WP_001300891 NZ_LN832404.1 # TIGRFAMs TIGR00686 phnA # eggNOG COG2824 LUCA # eggNOG ENOG4108Z8G Bacteria BLAST swissprot:PHNA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PHNA_ECOLI BioCyc ECOL316407:JW4069-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4069-MONOMER BioCyc EcoCyc:EG10711-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10711-MONOMER COG COG2824 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2824 DIP DIP-48079N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48079N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J05260 http://www.ebi.ac.uk/ena/data/view/J05260 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB0705 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0705 EcoGene EG10711 http://www.ecogene.org/geneInfo.php?eg_id=EG10711 EnsemblBacteria AAC77069 http://www.ensemblgenomes.org/id/AAC77069 EnsemblBacteria AAC77069 http://www.ensemblgenomes.org/id/AAC77069 EnsemblBacteria BAE78110 http://www.ensemblgenomes.org/id/BAE78110 EnsemblBacteria BAE78110 http://www.ensemblgenomes.org/id/BAE78110 EnsemblBacteria BAE78110 http://www.ensemblgenomes.org/id/BAE78110 EnsemblBacteria b4108 http://www.ensemblgenomes.org/id/b4108 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GeneID 948621 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948621 HOGENOM HOG000228486 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000228486&db=HOGENOM6 InParanoid P0AFJ1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFJ1 IntAct P0AFJ1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFJ1* InterPro IPR004624 http://www.ebi.ac.uk/interpro/entry/IPR004624 InterPro IPR013987 http://www.ebi.ac.uk/interpro/entry/IPR013987 InterPro IPR013988 http://www.ebi.ac.uk/interpro/entry/IPR013988 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4069 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4069 KEGG_Gene eco:b4108 http://www.genome.jp/dbget-bin/www_bget?eco:b4108 KEGG_Orthology KO:K06193 http://www.genome.jp/dbget-bin/www_bget?KO:K06193 KEGG_Pathway ko00440 http://www.genome.jp/kegg-bin/show_pathway?ko00440 KEGG_Reaction rn:R00318 http://www.genome.jp/dbget-bin/www_bget?rn:R00318 OMA SCLYEWN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SCLYEWN PSORT swissprot:PHNA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PHNA_ECOLI PSORT-B swissprot:PHNA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PHNA_ECOLI PSORT2 swissprot:PHNA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PHNA_ECOLI Pfam PF03831 http://pfam.xfam.org/family/PF03831 Pfam PF08274 http://pfam.xfam.org/family/PF08274 Phobius swissprot:PHNA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PHNA_ECOLI PhylomeDB P0AFJ1 http://phylomedb.org/?seqid=P0AFJ1 ProteinModelPortal P0AFJ1 http://www.proteinmodelportal.org/query/uniprot/P0AFJ1 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2155230 http://www.ncbi.nlm.nih.gov/pubmed/2155230 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418532 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418532 RefSeq WP_001300891 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300891 SMR P0AFJ1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFJ1 STRING 511145.b4108 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4108&targetmode=cogs STRING COG2824 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2824&targetmode=cogs TIGRFAMs TIGR00686 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00686 UniProtKB PHNA_ECOLI http://www.uniprot.org/uniprot/PHNA_ECOLI UniProtKB-AC P0AFJ1 http://www.uniprot.org/uniprot/P0AFJ1 charge swissprot:PHNA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PHNA_ECOLI eggNOG COG2824 http://eggnogapi.embl.de/nog_data/html/tree/COG2824 eggNOG ENOG4108Z8G http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Z8G epestfind swissprot:PHNA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PHNA_ECOLI garnier swissprot:PHNA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PHNA_ECOLI helixturnhelix swissprot:PHNA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PHNA_ECOLI hmoment swissprot:PHNA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PHNA_ECOLI iep swissprot:PHNA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PHNA_ECOLI inforesidue swissprot:PHNA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PHNA_ECOLI octanol swissprot:PHNA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PHNA_ECOLI pepcoil swissprot:PHNA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PHNA_ECOLI pepdigest swissprot:PHNA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PHNA_ECOLI pepinfo swissprot:PHNA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PHNA_ECOLI pepnet swissprot:PHNA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PHNA_ECOLI pepstats swissprot:PHNA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PHNA_ECOLI pepwheel swissprot:PHNA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PHNA_ECOLI pepwindow swissprot:PHNA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PHNA_ECOLI sigcleave swissprot:PHNA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PHNA_ECOLI ## Database ID URL or Descriptions # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # InterPro IPR007607 DUF583 # Organism YUAD_ECOLI Escherichia coli (strain K12) # Pfam PF04519 Bactofilin # RecName YUAD_ECOLI Uncharacterized membrane protein YuaD # RefSeq NP_061392 NC_002483.1 # RefSeq WP_010892523 NC_002483.1 # SUBCELLULAR LOCATION YUAD_ECOLI Membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. BLAST swissprot:YUAD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YUAD_ECOLI EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GeneID 1263503 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263503 InterPro IPR007607 http://www.ebi.ac.uk/interpro/entry/IPR007607 OMA LEGTCTS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LEGTCTS PSORT swissprot:YUAD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YUAD_ECOLI PSORT-B swissprot:YUAD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YUAD_ECOLI PSORT2 swissprot:YUAD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YUAD_ECOLI Pfam PF04519 http://pfam.xfam.org/family/PF04519 Phobius swissprot:YUAD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YUAD_ECOLI ProteinModelPortal Q9JMT6 http://www.proteinmodelportal.org/query/uniprot/Q9JMT6 RefSeq NP_061392 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061392 RefSeq WP_010892523 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_010892523 SMR Q9JMT6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q9JMT6 UniProtKB YUAD_ECOLI http://www.uniprot.org/uniprot/YUAD_ECOLI UniProtKB-AC Q9JMT6 http://www.uniprot.org/uniprot/Q9JMT6 charge swissprot:YUAD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YUAD_ECOLI epestfind swissprot:YUAD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YUAD_ECOLI garnier swissprot:YUAD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YUAD_ECOLI helixturnhelix swissprot:YUAD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YUAD_ECOLI hmoment swissprot:YUAD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YUAD_ECOLI iep swissprot:YUAD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YUAD_ECOLI inforesidue swissprot:YUAD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YUAD_ECOLI octanol swissprot:YUAD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YUAD_ECOLI pepcoil swissprot:YUAD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YUAD_ECOLI pepdigest swissprot:YUAD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YUAD_ECOLI pepinfo swissprot:YUAD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YUAD_ECOLI pepnet swissprot:YUAD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YUAD_ECOLI pepstats swissprot:YUAD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YUAD_ECOLI pepwheel swissprot:YUAD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YUAD_ECOLI pepwindow swissprot:YUAD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YUAD_ECOLI sigcleave swissprot:YUAD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YUAD_ECOLI ## Database ID URL or Descriptions # BioGrid 4262990 15 # DISRUPTION PHENOTYPE Dispensable for cell growth, cells lacking this gene have a shorter lag phase. {ECO:0000269|PubMed 20434458}. # EcoGene EG11835 yihI # FUNCTION YIHI_ECOLI A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function, negatively regulating cell growth, probably via ribosome assembly. Stimulates the GTPase activity of Der; a construct missing the first 45 residues is even more stimulatory. Does not stimulate 2 other GTPases (ObgE and Era). Overexpression inhibits cell growth; precursor 16S rRNA accumulates, the 23S rRNA is 6-7 bases longer than usual, and 50S ribosomal subunits are improperly assembled, leading to 45S subunits lacking proteins L9, L18 and L25. Overexpression of Der in the same cells suppresses the 50S subunit assembly defect, corroborating that YihI and Der interact. {ECO 0000269|PubMed 20434458}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0005096 GTPase activator activity; IEA:UniProtKB-KW. # GO_process GO:0042254 ribosome biogenesis; IEA:UniProtKB-KW. # GO_process GO:0043547 positive regulation of GTPase activity; IDA:EcoCyc. # GO_process GO:0090071 negative regulation of ribosome biogenesis; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0030234 enzyme regulator activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0042254 ribosome biogenesis # HAMAP MF_01058 GAP_YihI # INDUCTION Highly expressed during the lag phase, not expressed in later phases. {ECO:0000269|PubMed 20434458}. # IntAct P0A8H6 28 # InterPro IPR007336 Der_GTPase_activator # MISCELLANEOUS YIHI_ECOLI This is a highly hydrophilic protein; there is a stretch of highly charged residues in the N-terminus and a stretch of acidic residues in the C-terminus. # Organism YIHI_ECOLI Escherichia coli (strain K12) # PATRIC 32123231 VBIEscCol129921_3976 # PIR S40811 S40811 # Pfam PF04220 YihI # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIHI_ECOLI Der GTPase-activating protein YihI # RefSeq NP_418302 NC_000913.3 # RefSeq WP_001295266 NZ_LN832404.1 # SIMILARITY Belongs to the YihI family. {ECO 0000305}. # SUBUNIT Homodimer. Interacts with Der/EngA via the last 78 residues. Interaction with Der occurs at a 1:1 stoichiometry, suggesting the dimer dissociates to interact with Der. {ECO 0000269|PubMed:20434458}. # eggNOG COG3078 LUCA # eggNOG ENOG4105ZR3 Bacteria BLAST swissprot:YIHI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIHI_ECOLI BioCyc ECOL316407:JW3837-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3837-MONOMER BioCyc EcoCyc:EG11835-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11835-MONOMER COG COG3078 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3078 DIP DIP-47963N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47963N DOI 10.1016/j.jmb.2010.04.040 http://dx.doi.org/10.1016/j.jmb.2010.04.040 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D16509 http://www.ebi.ac.uk/ena/data/view/D16509 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1781 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1781 EcoGene EG11835 http://www.ecogene.org/geneInfo.php?eg_id=EG11835 EnsemblBacteria AAC76863 http://www.ensemblgenomes.org/id/AAC76863 EnsemblBacteria AAC76863 http://www.ensemblgenomes.org/id/AAC76863 EnsemblBacteria BAE77443 http://www.ensemblgenomes.org/id/BAE77443 EnsemblBacteria BAE77443 http://www.ensemblgenomes.org/id/BAE77443 EnsemblBacteria BAE77443 http://www.ensemblgenomes.org/id/BAE77443 EnsemblBacteria b3866 http://www.ensemblgenomes.org/id/b3866 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0005096 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005096 GO_process GO:0042254 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042254 GO_process GO:0043547 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043547 GO_process GO:0090071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090071 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0030234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030234 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0042254 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042254 GeneID 948363 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948363 HAMAP MF_01058 http://hamap.expasy.org/unirule/MF_01058 HOGENOM HOG000002380 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000002380&db=HOGENOM6 IntAct P0A8H6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8H6* InterPro IPR007336 http://www.ebi.ac.uk/interpro/entry/IPR007336 KEGG_Gene ecj:JW3837 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3837 KEGG_Gene eco:b3866 http://www.genome.jp/dbget-bin/www_bget?eco:b3866 KEGG_Orthology KO:K09894 http://www.genome.jp/dbget-bin/www_bget?KO:K09894 MINT MINT-1218965 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1218965 OMA ENNECLN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ENNECLN PSORT swissprot:YIHI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIHI_ECOLI PSORT-B swissprot:YIHI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIHI_ECOLI PSORT2 swissprot:YIHI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIHI_ECOLI Pfam PF04220 http://pfam.xfam.org/family/PF04220 Phobius swissprot:YIHI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIHI_ECOLI ProteinModelPortal P0A8H6 http://www.proteinmodelportal.org/query/uniprot/P0A8H6 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20434458 http://www.ncbi.nlm.nih.gov/pubmed/20434458 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418302 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418302 RefSeq WP_001295266 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295266 STRING 511145.b3866 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3866&targetmode=cogs STRING COG3078 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3078&targetmode=cogs UniProtKB YIHI_ECOLI http://www.uniprot.org/uniprot/YIHI_ECOLI UniProtKB-AC P0A8H6 http://www.uniprot.org/uniprot/P0A8H6 charge swissprot:YIHI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIHI_ECOLI eggNOG COG3078 http://eggnogapi.embl.de/nog_data/html/tree/COG3078 eggNOG ENOG4105ZR3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ZR3 epestfind swissprot:YIHI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIHI_ECOLI garnier swissprot:YIHI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIHI_ECOLI helixturnhelix swissprot:YIHI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIHI_ECOLI hmoment swissprot:YIHI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIHI_ECOLI iep swissprot:YIHI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIHI_ECOLI inforesidue swissprot:YIHI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIHI_ECOLI octanol swissprot:YIHI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIHI_ECOLI pepcoil swissprot:YIHI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIHI_ECOLI pepdigest swissprot:YIHI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIHI_ECOLI pepinfo swissprot:YIHI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIHI_ECOLI pepnet swissprot:YIHI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIHI_ECOLI pepstats swissprot:YIHI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIHI_ECOLI pepwheel swissprot:YIHI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIHI_ECOLI pepwindow swissprot:YIHI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIHI_ECOLI sigcleave swissprot:YIHI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIHI_ECOLI ## Database ID URL or Descriptions # BioGrid 4259374 158 # EcoGene EG10309 fimB # FUNCTION FIMB_ECOLI FimB is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, FimA. FimB switches FimA on. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_process GO:0006310 DNA recombination; IMP:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0015074 DNA integration; IMP:EcoCyc. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.443.10 -; 1. # IntAct P0ADH5 23 # InterPro IPR002104 Integrase_catalytic # InterPro IPR011010 DNA_brk_join_enz # InterPro IPR013762 Integrase-like_cat # Organism FIMB_ECOLI Escherichia coli (strain K12) # PATRIC 32124220 VBIEscCol129921_4453 # PIR S56537 RGECFF # Pfam PF00589 Phage_integrase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FIMB_ECOLI Type 1 fimbriae regulatory protein FimB # RefSeq NP_418732 NC_000913.3 # RefSeq WP_000790583 NZ_LN832404.1 # SIMILARITY Belongs to the 'phage' integrase family. {ECO 0000305}. # SUPFAM SSF56349 SSF56349 # eggNOG ENOG4108W9T Bacteria # eggNOG ENOG410YF4U LUCA BLAST swissprot:FIMB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FIMB_ECOLI BioCyc ECOL316407:JW4275-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4275-MONOMER BioCyc EcoCyc:EG10309-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10309-MONOMER COG COG0582 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0582 DIP DIP-47842N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47842N DOI 10.1007/BF00285286 http://dx.doi.org/10.1007/BF00285286 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L07756 http://www.ebi.ac.uk/ena/data/view/L07756 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X03923 http://www.ebi.ac.uk/ena/data/view/X03923 EchoBASE EB0305 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0305 EcoGene EG10309 http://www.ecogene.org/geneInfo.php?eg_id=EG10309 EnsemblBacteria AAC77268 http://www.ensemblgenomes.org/id/AAC77268 EnsemblBacteria AAC77268 http://www.ensemblgenomes.org/id/AAC77268 EnsemblBacteria BAE78305 http://www.ensemblgenomes.org/id/BAE78305 EnsemblBacteria BAE78305 http://www.ensemblgenomes.org/id/BAE78305 EnsemblBacteria BAE78305 http://www.ensemblgenomes.org/id/BAE78305 EnsemblBacteria b4312 http://www.ensemblgenomes.org/id/b4312 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0015074 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015074 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.443.10 http://www.cathdb.info/version/latest/superfamily/1.10.443.10 GeneID 948832 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948832 HOGENOM HOG000117333 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117333&db=HOGENOM6 InParanoid P0ADH5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADH5 IntAct P0ADH5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADH5* InterPro IPR002104 http://www.ebi.ac.uk/interpro/entry/IPR002104 InterPro IPR011010 http://www.ebi.ac.uk/interpro/entry/IPR011010 InterPro IPR013762 http://www.ebi.ac.uk/interpro/entry/IPR013762 KEGG_Gene ecj:JW4275 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4275 KEGG_Gene eco:b4312 http://www.genome.jp/dbget-bin/www_bget?eco:b4312 KEGG_Orthology KO:K07357 http://www.genome.jp/dbget-bin/www_bget?KO:K07357 MINT MINT-1221137 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1221137 OMA NFLTQNE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NFLTQNE PSORT swissprot:FIMB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FIMB_ECOLI PSORT-B swissprot:FIMB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FIMB_ECOLI PSORT2 swissprot:FIMB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FIMB_ECOLI Pfam PF00589 http://pfam.xfam.org/family/PF00589 Phobius swissprot:FIMB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FIMB_ECOLI PhylomeDB P0ADH5 http://phylomedb.org/?seqid=P0ADH5 ProteinModelPortal P0ADH5 http://www.proteinmodelportal.org/query/uniprot/P0ADH5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2874022 http://www.ncbi.nlm.nih.gov/pubmed/2874022 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 8121417 http://www.ncbi.nlm.nih.gov/pubmed/8121417 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418732 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418732 RefSeq WP_000790583 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000790583 SMR P0ADH5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADH5 STRING 511145.b4312 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4312&targetmode=cogs STRING COG0582 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0582&targetmode=cogs SUPFAM SSF56349 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56349 UniProtKB FIMB_ECOLI http://www.uniprot.org/uniprot/FIMB_ECOLI UniProtKB-AC P0ADH5 http://www.uniprot.org/uniprot/P0ADH5 charge swissprot:FIMB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FIMB_ECOLI eggNOG ENOG4108W9T http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108W9T eggNOG ENOG410YF4U http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YF4U epestfind swissprot:FIMB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FIMB_ECOLI garnier swissprot:FIMB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FIMB_ECOLI helixturnhelix swissprot:FIMB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FIMB_ECOLI hmoment swissprot:FIMB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FIMB_ECOLI iep swissprot:FIMB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FIMB_ECOLI inforesidue swissprot:FIMB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FIMB_ECOLI octanol swissprot:FIMB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FIMB_ECOLI pepcoil swissprot:FIMB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FIMB_ECOLI pepdigest swissprot:FIMB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FIMB_ECOLI pepinfo swissprot:FIMB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FIMB_ECOLI pepnet swissprot:FIMB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FIMB_ECOLI pepstats swissprot:FIMB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FIMB_ECOLI pepwheel swissprot:FIMB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FIMB_ECOLI pepwindow swissprot:FIMB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FIMB_ECOLI sigcleave swissprot:FIMB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FIMB_ECOLI ## Database ID URL or Descriptions # Organism YUAS_ECOLI Escherichia coli (strain K12) # RecName YUAS_ECOLI Uncharacterized protein YuaS # RefSeq NP_061410 NC_002483.1 # RefSeq WP_010892531 NC_002483.1 BLAST swissprot:YUAS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YUAS_ECOLI EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1263502 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263502 PSORT swissprot:YUAS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YUAS_ECOLI PSORT-B swissprot:YUAS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YUAS_ECOLI PSORT2 swissprot:YUAS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YUAS_ECOLI Phobius swissprot:YUAS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YUAS_ECOLI ProteinModelPortal Q9JMS2 http://www.proteinmodelportal.org/query/uniprot/Q9JMS2 RefSeq NP_061410 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061410 RefSeq WP_010892531 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_010892531 UniProtKB YUAS_ECOLI http://www.uniprot.org/uniprot/YUAS_ECOLI UniProtKB-AC Q9JMS2 http://www.uniprot.org/uniprot/Q9JMS2 charge swissprot:YUAS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YUAS_ECOLI epestfind swissprot:YUAS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YUAS_ECOLI garnier swissprot:YUAS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YUAS_ECOLI helixturnhelix swissprot:YUAS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YUAS_ECOLI hmoment swissprot:YUAS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YUAS_ECOLI iep swissprot:YUAS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YUAS_ECOLI inforesidue swissprot:YUAS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YUAS_ECOLI octanol swissprot:YUAS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YUAS_ECOLI pepcoil swissprot:YUAS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YUAS_ECOLI pepdigest swissprot:YUAS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YUAS_ECOLI pepinfo swissprot:YUAS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YUAS_ECOLI pepnet swissprot:YUAS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YUAS_ECOLI pepstats swissprot:YUAS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YUAS_ECOLI pepwheel swissprot:YUAS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YUAS_ECOLI pepwindow swissprot:YUAS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YUAS_ECOLI sigcleave swissprot:YUAS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YUAS_ECOLI ## Database ID URL or Descriptions # AltName NLPC_ECOLI ORF-17 # AltName NLPC_ECOLI Probable lipoprotein NlpC # BioGrid 4260300 301 # EcoGene EG11133 nlpC # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_function GO:0008234 cysteine-type peptidase activity; IEA:UniProtKB-KW. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0008233 peptidase activity # Gene3D 3.90.1720.10 -; 1. # InterPro IPR000064 NLP_P60_dom # KEGG_Brite ko01002 Peptidases # Organism NLPC_ECOLI Escherichia coli (strain K12) # PATRIC 32118722 VBIEscCol129921_1779 # PIR D64929 D64929 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF00877 NLPC_P60 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NLPC_ECOLI Probable endopeptidase NlpC # RefSeq NP_416223 NC_000913.3 # RefSeq WP_001209795 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase C40 family. {ECO 0000305}. # SUBCELLULAR LOCATION NLPC_ECOLI Cell membrane {ECO 0000305}; Lipid-anchor {ECO 0000305}. # eggNOG COG0791 LUCA # eggNOG ENOG4108QBX Bacteria BLAST swissprot:NLPC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NLPC_ECOLI BioCyc ECOL316407:JW1698-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1698-MONOMER BioCyc EcoCyc:EG11133-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11133-MONOMER COG COG0791 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0791 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.4.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M14031 http://www.ebi.ac.uk/ena/data/view/M14031 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.4.-.- http://enzyme.expasy.org/EC/3.4.-.- EchoBASE EB1123 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1123 EcoGene EG11133 http://www.ecogene.org/geneInfo.php?eg_id=EG11133 EnsemblBacteria AAC74778 http://www.ensemblgenomes.org/id/AAC74778 EnsemblBacteria AAC74778 http://www.ensemblgenomes.org/id/AAC74778 EnsemblBacteria BAA15476 http://www.ensemblgenomes.org/id/BAA15476 EnsemblBacteria BAA15476 http://www.ensemblgenomes.org/id/BAA15476 EnsemblBacteria BAA15476 http://www.ensemblgenomes.org/id/BAA15476 EnsemblBacteria b1708 http://www.ensemblgenomes.org/id/b1708 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0008234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008234 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 Gene3D 3.90.1720.10 http://www.cathdb.info/version/latest/superfamily/3.90.1720.10 GeneID 946220 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946220 HOGENOM HOG000229978 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000229978&db=HOGENOM6 InParanoid P23898 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23898 IntEnz 3.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4 InterPro IPR000064 http://www.ebi.ac.uk/interpro/entry/IPR000064 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW1698 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1698 KEGG_Gene eco:b1708 http://www.genome.jp/dbget-bin/www_bget?eco:b1708 KEGG_Orthology KO:K13695 http://www.genome.jp/dbget-bin/www_bget?KO:K13695 OMA DSIMVMV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DSIMVMV PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:NLPC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NLPC_ECOLI PSORT-B swissprot:NLPC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NLPC_ECOLI PSORT2 swissprot:NLPC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NLPC_ECOLI Pfam PF00877 http://pfam.xfam.org/family/PF00877 Phobius swissprot:NLPC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NLPC_ECOLI PhylomeDB P23898 http://phylomedb.org/?seqid=P23898 ProteinModelPortal P23898 http://www.proteinmodelportal.org/query/uniprot/P23898 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416223 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416223 RefSeq WP_001209795 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001209795 SMR P23898 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P23898 STRING 511145.b1708 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1708&targetmode=cogs STRING COG0791 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0791&targetmode=cogs UniProtKB NLPC_ECOLI http://www.uniprot.org/uniprot/NLPC_ECOLI UniProtKB-AC P23898 http://www.uniprot.org/uniprot/P23898 charge swissprot:NLPC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NLPC_ECOLI eggNOG COG0791 http://eggnogapi.embl.de/nog_data/html/tree/COG0791 eggNOG ENOG4108QBX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108QBX epestfind swissprot:NLPC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NLPC_ECOLI garnier swissprot:NLPC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NLPC_ECOLI helixturnhelix swissprot:NLPC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NLPC_ECOLI hmoment swissprot:NLPC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NLPC_ECOLI iep swissprot:NLPC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NLPC_ECOLI inforesidue swissprot:NLPC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NLPC_ECOLI octanol swissprot:NLPC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NLPC_ECOLI pepcoil swissprot:NLPC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NLPC_ECOLI pepdigest swissprot:NLPC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NLPC_ECOLI pepinfo swissprot:NLPC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NLPC_ECOLI pepnet swissprot:NLPC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NLPC_ECOLI pepstats swissprot:NLPC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NLPC_ECOLI pepwheel swissprot:NLPC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NLPC_ECOLI pepwindow swissprot:NLPC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NLPC_ECOLI sigcleave swissprot:NLPC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NLPC_ECOLI ## Database ID URL or Descriptions # AltName INSA4_ECOLI IS1d # EcoGene EG40001 insA4 # FUNCTION INSA4_ECOLI Absolutely required for transposition of IS1. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IEA:InterPro. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 1.10.10.60 -; 1. # InterPro IPR003220 InsA_N_dom # InterPro IPR009057 Homeodomain-like # InterPro IPR024431 InsA_HTH_dom # Organism INSA4_ECOLI Escherichia coli (strain K12) # PIR B93826 IEECB9 # PIR JN0134 JN0134 # Pfam PF03811 Zn_Tnp_IS1 # Pfam PF12759 HTH_Tnp_IS1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSA4_ECOLI Insertion element IS1 4 protein InsA # RefSeq NP_414799 NC_000913.3 # RefSeq NP_414809 NC_000913.3 # RefSeq NP_862965 NC_004998.1 # RefSeq NP_863031 NC_004998.1 # RefSeq NP_957637 NC_005327.1 # RefSeq WP_000179210 NZ_LN832404.1 # RefSeq YP_001096420 NC_009133.1 # RefSeq YP_001096518 NC_009133.1 # RefSeq YP_001816581 NC_010558.1 # RefSeq YP_001816635 NC_010558.1 # RefSeq YP_002527566 NC_011964.1 # RefSeq YP_003108318 NC_013122.1 # RefSeq YP_006953891 NC_019090.1 # RefSeq YP_006954228 NC_019095.1 # RefSeq YP_006990704 NC_019424.1 # RefSeq YP_007447506 NC_020278.2 # RefSeq YP_009071497 NC_025183.1 # RefSeq YP_588445 NC_000913.3 # SIMILARITY Belongs to the IS1 elements InsA family. {ECO 0000305}. # eggNOG COG3677 LUCA BLAST swissprot:INSA4_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSA4_ECOLI BioCyc EcoCyc:MONOMER0-4228 http://biocyc.org/getid?id=EcoCyc:MONOMER0-4228 DIP DIP-16998N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-16998N DOI 10.1016/0378-1119(91)90096-T http://dx.doi.org/10.1016/0378-1119(91)90096-T DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X52536 http://www.ebi.ac.uk/ena/data/view/X52536 EcoGene EG40001 http://www.ecogene.org/geneInfo.php?eg_id=EG40001 EnsemblBacteria ABD18646 http://www.ensemblgenomes.org/id/ABD18646 EnsemblBacteria ABD18646 http://www.ensemblgenomes.org/id/ABD18646 EnsemblBacteria BAA35753 http://www.ensemblgenomes.org/id/BAA35753 EnsemblBacteria BAA35753 http://www.ensemblgenomes.org/id/BAA35753 EnsemblBacteria BAA35753 http://www.ensemblgenomes.org/id/BAA35753 EnsemblBacteria b4516 http://www.ensemblgenomes.org/id/b4516 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 GeneID 13906835 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13906835 GeneID 13906917 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13906917 GeneID 13982288 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13982288 GeneID 1446608 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1446608 GeneID 1446614 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1446614 GeneID 1450250 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1450250 GeneID 14612516 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14612516 GeneID 20493569 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20493569 GeneID 2716512 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2716512 GeneID 4924745 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4924745 GeneID 4924843 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4924843 GeneID 6275933 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6275933 GeneID 6276036 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6276036 GeneID 7324590 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7324590 GeneID 8319248 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8319248 GeneID 944946 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944946 GeneID 944951 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944951 InParanoid P0CF10 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CF10 InterPro IPR003220 http://www.ebi.ac.uk/interpro/entry/IPR003220 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR024431 http://www.ebi.ac.uk/interpro/entry/IPR024431 KEGG_Gene ecj:JW0971 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0971 KEGG_Gene eco:b0265 http://www.genome.jp/dbget-bin/www_bget?eco:b0265 KEGG_Gene eco:b0275 http://www.genome.jp/dbget-bin/www_bget?eco:b0275 KEGG_Gene eco:b4516 http://www.genome.jp/dbget-bin/www_bget?eco:b4516 PSORT swissprot:INSA4_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSA4_ECOLI PSORT-B swissprot:INSA4_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSA4_ECOLI PSORT2 swissprot:INSA4_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSA4_ECOLI Pfam PF03811 http://pfam.xfam.org/family/PF03811 Pfam PF12759 http://pfam.xfam.org/family/PF12759 Phobius swissprot:INSA4_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSA4_ECOLI ProteinModelPortal P0CF10 http://www.proteinmodelportal.org/query/uniprot/P0CF10 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1849492 http://www.ncbi.nlm.nih.gov/pubmed/1849492 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414799 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414799 RefSeq NP_414809 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414809 RefSeq NP_862965 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_862965 RefSeq NP_863031 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_863031 RefSeq NP_957637 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_957637 RefSeq WP_000179210 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000179210 RefSeq YP_001096420 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001096420 RefSeq YP_001096518 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001096518 RefSeq YP_001816581 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001816581 RefSeq YP_001816635 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001816635 RefSeq YP_002527566 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_002527566 RefSeq YP_003108318 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_003108318 RefSeq YP_006953891 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_006953891 RefSeq YP_006954228 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_006954228 RefSeq YP_006990704 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_006990704 RefSeq YP_007447506 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_007447506 RefSeq YP_009071497 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009071497 RefSeq YP_588445 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_588445 STRING 511145.b4516 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4516&targetmode=cogs UniProtKB INSA4_ECOLI http://www.uniprot.org/uniprot/INSA4_ECOLI UniProtKB-AC P0CF10 http://www.uniprot.org/uniprot/P0CF10 charge swissprot:INSA4_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSA4_ECOLI eggNOG COG3677 http://eggnogapi.embl.de/nog_data/html/tree/COG3677 epestfind swissprot:INSA4_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSA4_ECOLI garnier swissprot:INSA4_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSA4_ECOLI helixturnhelix swissprot:INSA4_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSA4_ECOLI hmoment swissprot:INSA4_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSA4_ECOLI iep swissprot:INSA4_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSA4_ECOLI inforesidue swissprot:INSA4_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSA4_ECOLI octanol swissprot:INSA4_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSA4_ECOLI pepcoil swissprot:INSA4_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSA4_ECOLI pepdigest swissprot:INSA4_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSA4_ECOLI pepinfo swissprot:INSA4_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSA4_ECOLI pepnet swissprot:INSA4_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSA4_ECOLI pepstats swissprot:INSA4_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSA4_ECOLI pepwheel swissprot:INSA4_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSA4_ECOLI pepwindow swissprot:INSA4_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSA4_ECOLI sigcleave swissprot:INSA4_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSA4_ECOLI ## Database ID URL or Descriptions # BioGrid 4259627 15 # EcoGene EG11688 yicL # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006810 transport; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006810 transport # InterPro IPR000620 EamA_dom # InterPro IPR004779 CO/AA/NH_transpt # Organism YICL_ECOLI Escherichia coli (strain K12) # PATRIC 32122809 VBIEscCol129921_3780 # PIR E65167 E65167 # Pfam PF00892 EamA; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YICL_ECOLI Uncharacterized inner membrane transporter YicL # RefSeq NP_418116 NC_000913.3 # RefSeq WP_000535961 NZ_LN832404.1 # SIMILARITY Belongs to the EamA transporter family. {ECO 0000305}. # SIMILARITY Contains 2 EamA domains. {ECO 0000305}. # SUBCELLULAR LOCATION YICL_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.7.3.12 the drug/metabolite transporter (dmt) superfamily # TIGRFAMs TIGR00950 2A78 # eggNOG COG0697 LUCA # eggNOG ENOG4108UZ3 Bacteria BLAST swissprot:YICL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YICL_ECOLI BioCyc ECOL316407:JW3634-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3634-MONOMER BioCyc EcoCyc:EG11688-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11688-MONOMER DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1639 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1639 EcoGene EG11688 http://www.ecogene.org/geneInfo.php?eg_id=EG11688 EnsemblBacteria AAC76683 http://www.ensemblgenomes.org/id/AAC76683 EnsemblBacteria AAC76683 http://www.ensemblgenomes.org/id/AAC76683 EnsemblBacteria BAE77634 http://www.ensemblgenomes.org/id/BAE77634 EnsemblBacteria BAE77634 http://www.ensemblgenomes.org/id/BAE77634 EnsemblBacteria BAE77634 http://www.ensemblgenomes.org/id/BAE77634 EnsemblBacteria b3660 http://www.ensemblgenomes.org/id/b3660 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948176 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948176 HOGENOM HOG000083322 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000083322&db=HOGENOM6 InParanoid P31437 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31437 InterPro IPR000620 http://www.ebi.ac.uk/interpro/entry/IPR000620 InterPro IPR004779 http://www.ebi.ac.uk/interpro/entry/IPR004779 KEGG_Gene ecj:JW3634 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3634 KEGG_Gene eco:b3660 http://www.genome.jp/dbget-bin/www_bget?eco:b3660 OMA QYIMEKS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QYIMEKS PSORT swissprot:YICL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YICL_ECOLI PSORT-B swissprot:YICL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YICL_ECOLI PSORT2 swissprot:YICL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YICL_ECOLI Pfam PF00892 http://pfam.xfam.org/family/PF00892 Phobius swissprot:YICL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YICL_ECOLI PhylomeDB P31437 http://phylomedb.org/?seqid=P31437 ProteinModelPortal P31437 http://www.proteinmodelportal.org/query/uniprot/P31437 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418116 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418116 RefSeq WP_000535961 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000535961 STRING 511145.b3660 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3660&targetmode=cogs TCDB 2.A.7.3.12 http://www.tcdb.org/search/result.php?tc=2.A.7.3.12 TIGRFAMs TIGR00950 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00950 UniProtKB YICL_ECOLI http://www.uniprot.org/uniprot/YICL_ECOLI UniProtKB-AC P31437 http://www.uniprot.org/uniprot/P31437 charge swissprot:YICL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YICL_ECOLI eggNOG COG0697 http://eggnogapi.embl.de/nog_data/html/tree/COG0697 eggNOG ENOG4108UZ3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UZ3 epestfind swissprot:YICL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YICL_ECOLI garnier swissprot:YICL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YICL_ECOLI helixturnhelix swissprot:YICL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YICL_ECOLI hmoment swissprot:YICL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YICL_ECOLI iep swissprot:YICL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YICL_ECOLI inforesidue swissprot:YICL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YICL_ECOLI octanol swissprot:YICL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YICL_ECOLI pepcoil swissprot:YICL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YICL_ECOLI pepdigest swissprot:YICL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YICL_ECOLI pepinfo swissprot:YICL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YICL_ECOLI pepnet swissprot:YICL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YICL_ECOLI pepstats swissprot:YICL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YICL_ECOLI pepwheel swissprot:YICL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YICL_ECOLI pepwindow swissprot:YICL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YICL_ECOLI sigcleave swissprot:YICL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YICL_ECOLI ## Database ID URL or Descriptions # BioGrid 4262449 393 # EcoGene EG10610 mreD # FUNCTION MRED_ECOLI Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; ISM:EcoCyc. # GO_process GO:0008360 regulation of cell shape; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0008150 biological_process # InterPro IPR007227 Cell_shape_determining_MreD # InterPro IPR026034 MreD_proteobac # KEGG_Brite ko03036 Chromosome # Organism MRED_ECOLI Escherichia coli (strain K12) # PATRIC 32121924 VBIEscCol129921_3346 # PIR JV0060 JV0060 # PIRSF PIRSF018472 MreD_proteobac # Pfam PF04093 MreD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MRED_ECOLI Rod shape-determining protein MreD # RefSeq NP_417715 NC_000913.3 # RefSeq WP_000179409 NZ_LN832404.1 # SIMILARITY Belongs to the MreD family. {ECO 0000305}. # SUBCELLULAR LOCATION MRED_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 9.B.157.1 the cell shape-determining mrebcd (mrebcd) family # TIGRFAMs TIGR03426 shape_MreD # eggNOG COG2891 LUCA # eggNOG ENOG4105VQ7 Bacteria BLAST swissprot:MRED_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MRED_ECOLI BioCyc ECOL316407:JW3218-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3218-MONOMER BioCyc EcoCyc:EG10610-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10610-MONOMER COG COG2891 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2891 DIP DIP-10257N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10257N DOI 10.1016/0378-1119(91)90578-Y http://dx.doi.org/10.1016/0378-1119(91)90578-Y DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M31792 http://www.ebi.ac.uk/ena/data/view/M31792 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X57166 http://www.ebi.ac.uk/ena/data/view/X57166 EchoBASE EB0605 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0605 EcoGene EG10610 http://www.ecogene.org/geneInfo.php?eg_id=EG10610 EnsemblBacteria AAC76281 http://www.ensemblgenomes.org/id/AAC76281 EnsemblBacteria AAC76281 http://www.ensemblgenomes.org/id/AAC76281 EnsemblBacteria BAE77291 http://www.ensemblgenomes.org/id/BAE77291 EnsemblBacteria BAE77291 http://www.ensemblgenomes.org/id/BAE77291 EnsemblBacteria BAE77291 http://www.ensemblgenomes.org/id/BAE77291 EnsemblBacteria b3249 http://www.ensemblgenomes.org/id/b3249 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 947756 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947756 HOGENOM HOG000266108 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000266108&db=HOGENOM6 InParanoid P0ABH4 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABH4 InterPro IPR007227 http://www.ebi.ac.uk/interpro/entry/IPR007227 InterPro IPR026034 http://www.ebi.ac.uk/interpro/entry/IPR026034 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene ecj:JW3218 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3218 KEGG_Gene eco:b3249 http://www.genome.jp/dbget-bin/www_bget?eco:b3249 KEGG_Orthology KO:K03571 http://www.genome.jp/dbget-bin/www_bget?KO:K03571 OMA RNYSVWQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RNYSVWQ PSORT swissprot:MRED_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MRED_ECOLI PSORT-B swissprot:MRED_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MRED_ECOLI PSORT2 swissprot:MRED_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MRED_ECOLI Pfam PF04093 http://pfam.xfam.org/family/PF04093 Phobius swissprot:MRED_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MRED_ECOLI ProteinModelPortal P0ABH4 http://www.proteinmodelportal.org/query/uniprot/P0ABH4 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1937035 http://www.ncbi.nlm.nih.gov/pubmed/1937035 PubMed 2687239 http://www.ncbi.nlm.nih.gov/pubmed/2687239 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417715 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417715 RefSeq WP_000179409 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000179409 STRING 511145.b3249 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3249&targetmode=cogs STRING COG2891 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2891&targetmode=cogs TCDB 9.B.157.1 http://www.tcdb.org/search/result.php?tc=9.B.157.1 TIGRFAMs TIGR03426 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03426 UniProtKB MRED_ECOLI http://www.uniprot.org/uniprot/MRED_ECOLI UniProtKB-AC P0ABH4 http://www.uniprot.org/uniprot/P0ABH4 charge swissprot:MRED_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MRED_ECOLI eggNOG COG2891 http://eggnogapi.embl.de/nog_data/html/tree/COG2891 eggNOG ENOG4105VQ7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VQ7 epestfind swissprot:MRED_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MRED_ECOLI garnier swissprot:MRED_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MRED_ECOLI helixturnhelix swissprot:MRED_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MRED_ECOLI hmoment swissprot:MRED_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MRED_ECOLI iep swissprot:MRED_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MRED_ECOLI inforesidue swissprot:MRED_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MRED_ECOLI octanol swissprot:MRED_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MRED_ECOLI pepcoil swissprot:MRED_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MRED_ECOLI pepdigest swissprot:MRED_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MRED_ECOLI pepinfo swissprot:MRED_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MRED_ECOLI pepnet swissprot:MRED_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MRED_ECOLI pepstats swissprot:MRED_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MRED_ECOLI pepwheel swissprot:MRED_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MRED_ECOLI pepwindow swissprot:MRED_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MRED_ECOLI sigcleave swissprot:MRED_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MRED_ECOLI ## Database ID URL or Descriptions # BioGrid 4261056 7 # EcoGene EG13280 yedM # InterPro IPR020484 Uncharacterised_YedM # Organism YEDM_ECOLI Escherichia coli (strain K12) # PIR D64957 D64957 # ProDom PD074737 Uncharacterised_YedM # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEDM_ECOLI Uncharacterized protein YedM # eggNOG COG4886 LUCA BLAST swissprot:YEDM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEDM_ECOLI BioCyc ECOL316407:JW1920-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1920-MONOMER BioCyc EcoCyc:G7043-MONOMER http://biocyc.org/getid?id=EcoCyc:G7043-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1099/00221287-139-7-1401 http://dx.doi.org/10.1099/00221287-139-7-1401 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L13279 http://www.ebi.ac.uk/ena/data/view/L13279 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3065 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3065 EcoGene EG13280 http://www.ecogene.org/geneInfo.php?eg_id=EG13280 EnsemblBacteria BAE76553 http://www.ensemblgenomes.org/id/BAE76553 EnsemblBacteria BAE76553 http://www.ensemblgenomes.org/id/BAE76553 EnsemblBacteria BAE76553 http://www.ensemblgenomes.org/id/BAE76553 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv IntAct P76322 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76322* InterPro IPR020484 http://www.ebi.ac.uk/interpro/entry/IPR020484 KEGG_Gene ecj:JW1920 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1920 PSORT swissprot:YEDM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEDM_ECOLI PSORT-B swissprot:YEDM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEDM_ECOLI PSORT2 swissprot:YEDM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEDM_ECOLI Phobius swissprot:YEDM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEDM_ECOLI ProteinModelPortal P76322 http://www.proteinmodelportal.org/query/uniprot/P76322 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8371104 http://www.ncbi.nlm.nih.gov/pubmed/8371104 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SMR P76322 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76322 STRING 316407.85675165 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85675165&targetmode=cogs UniProtKB YEDM_ECOLI http://www.uniprot.org/uniprot/YEDM_ECOLI UniProtKB-AC P76322 http://www.uniprot.org/uniprot/P76322 charge swissprot:YEDM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEDM_ECOLI eggNOG COG4886 http://eggnogapi.embl.de/nog_data/html/tree/COG4886 epestfind swissprot:YEDM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEDM_ECOLI garnier swissprot:YEDM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEDM_ECOLI helixturnhelix swissprot:YEDM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEDM_ECOLI hmoment swissprot:YEDM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEDM_ECOLI iep swissprot:YEDM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEDM_ECOLI inforesidue swissprot:YEDM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEDM_ECOLI octanol swissprot:YEDM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEDM_ECOLI pepcoil swissprot:YEDM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEDM_ECOLI pepdigest swissprot:YEDM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEDM_ECOLI pepinfo swissprot:YEDM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEDM_ECOLI pepnet swissprot:YEDM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEDM_ECOLI pepstats swissprot:YEDM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEDM_ECOLI pepwheel swissprot:YEDM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEDM_ECOLI pepwindow swissprot:YEDM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEDM_ECOLI sigcleave swissprot:YEDM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEDM_ECOLI ## Database ID URL or Descriptions # BRENDA 2.7.8.B11 2026 # BioGrid 4260689 10 # CATALYTIC ACTIVITY CLSC_ECOLI Phosphatidylglycerol + phosphatidylethanolamine = diphosphatidylglycerol + ethanolamine. {ECO 0000255|HAMAP-Rule MF_01918, ECO 0000269|PubMed 22988102}. # DISRUPTION PHENOTYPE Triple deletion of clsA, clsB and clsC results in a complete lack of cardiolipin, regardless of growth phase or growth conditions. {ECO:0000269|PubMed 22988102}. # ENZYME REGULATION Full activity requires coexpression with the neighboring gene ymdB. {ECO:0000269|PubMed 22988102}. # EcoGene EG13875 clsC # FUNCTION CLSC_ECOLI Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) from phosphatidylglycerol (PG) and phosphatidylethanolamine (PE). # GO_component GO:0016020 membrane; IBA:GO_Central. # GO_function GO:0008808 cardiolipin synthase activity; IBA:GO_Central. # GO_function GO:0090483 phosphatidylglycerol-phosphatidylethanolamine phosphatidyltransferase activity; IDA:EcoCyc. # GO_process GO:0032049 cardiolipin biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # HAMAP MF_01918 Cardiolipin_synth_ClsC # InterPro IPR001736 PLipase_D/transphosphatidylase # InterPro IPR025202 PLD-like_dom # InterPro IPR030871 Cardiolipin_synth_ClsC # MISCELLANEOUS All three cardiolipin synthases (ClsA, ClsB and ClsC) contribute to CL synthesis in stationary phase. Only ClsA contributes to synthesis during logarithmic growth phase (PubMed:22988102). {ECO 0000305|PubMed:22988102}. # Organism CLSC_ECOLI Escherichia coli (strain K12) # PATRIC 32117329 VBIEscCol129921_1087 # PIR C64847 C64847 # PROSITE PS50035 PLD; 2 # Pfam PF13091 PLDc_2; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Cardiolipin synthase C {ECO:0000255|HAMAP-Rule MF_01918} # RefSeq NP_415564 NC_000913.3 # RefSeq WP_001299031 NZ_LN832404.1 # SIMILARITY Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsC sub-subfamily. {ECO:0000255|HAMAP- Rule MF_01918}. # SIMILARITY Contains 2 PLD phosphodiesterase domains. {ECO:0000255|HAMAP-Rule MF_01918}. # SMART SM00155 PLDc; 2 # eggNOG COG1502 LUCA # eggNOG ENOG4107RZC Bacteria BLAST swissprot:CLSC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CLSC_ECOLI BioCyc ECOL316407:JW5150-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5150-MONOMER BioCyc EcoCyc:G6551-MONOMER http://biocyc.org/getid?id=EcoCyc:G6551-MONOMER BioCyc MetaCyc:G6551-MONOMER http://biocyc.org/getid?id=MetaCyc:G6551-MONOMER DIP DIP-12712N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12712N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.1212797109 http://dx.doi.org/10.1073/pnas.1212797109 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.8.- {ECO:0000255|HAMAP-Rule:MF_01918} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.8.- {ECO:0000255|HAMAP-Rule:MF_01918} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.8.- {ECO:0000255|HAMAP-Rule:MF_01918} http://enzyme.expasy.org/EC/2.7.8.- {ECO:0000255|HAMAP-Rule:MF_01918} EchoBASE EB3634 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3634 EcoGene EG13875 http://www.ecogene.org/geneInfo.php?eg_id=EG13875 EnsemblBacteria AAC74130 http://www.ensemblgenomes.org/id/AAC74130 EnsemblBacteria AAC74130 http://www.ensemblgenomes.org/id/AAC74130 EnsemblBacteria BAA35836 http://www.ensemblgenomes.org/id/BAA35836 EnsemblBacteria BAA35836 http://www.ensemblgenomes.org/id/BAA35836 EnsemblBacteria BAA35836 http://www.ensemblgenomes.org/id/BAA35836 EnsemblBacteria b1046 http://www.ensemblgenomes.org/id/b1046 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0008808 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008808 GO_function GO:0090483 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090483 GO_process GO:0032049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032049 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 947321 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947321 HAMAP MF_01918 http://hamap.expasy.org/unirule/MF_01918 HOGENOM HOG000157571 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000157571&db=HOGENOM6 InParanoid P75919 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75919 IntAct P75919 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75919* IntEnz 2.7.8.- {ECO:0000255|HAMAP-Rule:MF_01918} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.8.- {ECO:0000255|HAMAP-Rule:MF_01918} InterPro IPR001736 http://www.ebi.ac.uk/interpro/entry/IPR001736 InterPro IPR025202 http://www.ebi.ac.uk/interpro/entry/IPR025202 InterPro IPR030871 http://www.ebi.ac.uk/interpro/entry/IPR030871 KEGG_Gene ecj:JW5150 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5150 KEGG_Gene eco:b1046 http://www.genome.jp/dbget-bin/www_bget?eco:b1046 OMA RNELIWA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RNELIWA PROSITE PS50035 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50035 PSORT swissprot:CLSC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CLSC_ECOLI PSORT-B swissprot:CLSC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CLSC_ECOLI PSORT2 swissprot:CLSC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CLSC_ECOLI Pfam PF13091 http://pfam.xfam.org/family/PF13091 Phobius swissprot:CLSC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CLSC_ECOLI PhylomeDB P75919 http://phylomedb.org/?seqid=P75919 ProteinModelPortal P75919 http://www.proteinmodelportal.org/query/uniprot/P75919 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22988102 http://www.ncbi.nlm.nih.gov/pubmed/22988102 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415564 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415564 RefSeq WP_001299031 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001299031 SMART SM00155 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00155 STRING 511145.b1046 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1046&targetmode=cogs UniProtKB CLSC_ECOLI http://www.uniprot.org/uniprot/CLSC_ECOLI UniProtKB-AC P75919 http://www.uniprot.org/uniprot/P75919 charge swissprot:CLSC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CLSC_ECOLI eggNOG COG1502 http://eggnogapi.embl.de/nog_data/html/tree/COG1502 eggNOG ENOG4107RZC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107RZC epestfind swissprot:CLSC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CLSC_ECOLI garnier swissprot:CLSC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CLSC_ECOLI helixturnhelix swissprot:CLSC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CLSC_ECOLI hmoment swissprot:CLSC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CLSC_ECOLI iep swissprot:CLSC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CLSC_ECOLI inforesidue swissprot:CLSC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CLSC_ECOLI octanol swissprot:CLSC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CLSC_ECOLI pepcoil swissprot:CLSC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CLSC_ECOLI pepdigest swissprot:CLSC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CLSC_ECOLI pepinfo swissprot:CLSC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CLSC_ECOLI pepnet swissprot:CLSC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CLSC_ECOLI pepstats swissprot:CLSC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CLSC_ECOLI pepwheel swissprot:CLSC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CLSC_ECOLI pepwindow swissprot:CLSC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CLSC_ECOLI sigcleave swissprot:CLSC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CLSC_ECOLI ## Database ID URL or Descriptions # BioGrid 4259116 6 # EcoGene EG13808 lsrD # FUNCTION LSRD_ECOLI Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane (Probable). {ECO 0000305|PubMed 15601708}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IBA:GO_Central. # GO_function GO:0015145 monosaccharide transmembrane transporter activity; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # INDUCTION LSRD_ECOLI In the absence of AI-2, repressed by LsrR. Induced by AI-2, via release of the LsrR repressor. In the absence of glucose, induced by cAMP-CRP by direct binding to the upstream region of the lsr promoter. {ECO 0000269|PubMed 15601708, ECO 0000269|PubMed 15743955}. # InterPro IPR001851 ABC_transp_permease # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00219 AI-2 transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism LSRD_ECOLI Escherichia coli (strain K12) # PATRIC 32118326 VBIEscCol129921_1583 # PIR F64905 F64905 # Pfam PF02653 BPD_transp_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LSRD_ECOLI Autoinducer 2 import system permease protein LsrD # RefSeq NP_416032 NC_000913.3 # RefSeq WP_001222721 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION LSRD_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT The complex is composed of two ATP-binding proteins (LsrA), two transmembrane proteins (LsrC and LsrD) and a solute- binding protein (LsrB). {ECO 0000305}. # TCDB 3.A.1.2 the atp-binding cassette (abc) superfamily # eggNOG ENOG4105F5R Bacteria # eggNOG ENOG410XS1A LUCA BLAST swissprot:LSRD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LSRD_ECOLI BioCyc ECOL316407:JW1508-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1508-MONOMER BioCyc EcoCyc:YDEZ-MONOMER http://biocyc.org/getid?id=EcoCyc:YDEZ-MONOMER BioCyc MetaCyc:YDEZ-MONOMER http://biocyc.org/getid?id=MetaCyc:YDEZ-MONOMER COG COG1172 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1172 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.187.1.238-248.2005 http://dx.doi.org/10.1128/JB.187.1.238-248.2005 DOI 10.1128/JB.187.6.2066-2076.2005 http://dx.doi.org/10.1128/JB.187.6.2066-2076.2005 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3569 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3569 EcoGene EG13808 http://www.ecogene.org/geneInfo.php?eg_id=EG13808 EnsemblBacteria AAC74588 http://www.ensemblgenomes.org/id/AAC74588 EnsemblBacteria AAC74588 http://www.ensemblgenomes.org/id/AAC74588 EnsemblBacteria BAA15202 http://www.ensemblgenomes.org/id/BAA15202 EnsemblBacteria BAA15202 http://www.ensemblgenomes.org/id/BAA15202 EnsemblBacteria BAA15202 http://www.ensemblgenomes.org/id/BAA15202 EnsemblBacteria b1515 http://www.ensemblgenomes.org/id/b1515 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015145 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GeneID 946264 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946264 HOGENOM HOG000212232 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000212232&db=HOGENOM6 InParanoid P0AFS1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFS1 InterPro IPR001851 http://www.ebi.ac.uk/interpro/entry/IPR001851 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1508 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1508 KEGG_Gene eco:b1515 http://www.genome.jp/dbget-bin/www_bget?eco:b1515 KEGG_Orthology KO:K10557 http://www.genome.jp/dbget-bin/www_bget?KO:K10557 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA LNPRMLD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LNPRMLD PSORT swissprot:LSRD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LSRD_ECOLI PSORT-B swissprot:LSRD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LSRD_ECOLI PSORT2 swissprot:LSRD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LSRD_ECOLI Pfam PF02653 http://pfam.xfam.org/family/PF02653 Phobius swissprot:LSRD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LSRD_ECOLI PhylomeDB P0AFS1 http://phylomedb.org/?seqid=P0AFS1 ProteinModelPortal P0AFS1 http://www.proteinmodelportal.org/query/uniprot/P0AFS1 PubMed 15601708 http://www.ncbi.nlm.nih.gov/pubmed/15601708 PubMed 15743955 http://www.ncbi.nlm.nih.gov/pubmed/15743955 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416032 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416032 RefSeq WP_001222721 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001222721 STRING 511145.b1515 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1515&targetmode=cogs STRING COG1172 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1172&targetmode=cogs TCDB 3.A.1.2 http://www.tcdb.org/search/result.php?tc=3.A.1.2 UniProtKB LSRD_ECOLI http://www.uniprot.org/uniprot/LSRD_ECOLI UniProtKB-AC P0AFS1 http://www.uniprot.org/uniprot/P0AFS1 charge swissprot:LSRD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LSRD_ECOLI eggNOG ENOG4105F5R http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F5R eggNOG ENOG410XS1A http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XS1A epestfind swissprot:LSRD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LSRD_ECOLI garnier swissprot:LSRD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LSRD_ECOLI helixturnhelix swissprot:LSRD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LSRD_ECOLI hmoment swissprot:LSRD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LSRD_ECOLI iep swissprot:LSRD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LSRD_ECOLI inforesidue swissprot:LSRD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LSRD_ECOLI octanol swissprot:LSRD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LSRD_ECOLI pepcoil swissprot:LSRD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LSRD_ECOLI pepdigest swissprot:LSRD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LSRD_ECOLI pepinfo swissprot:LSRD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LSRD_ECOLI pepnet swissprot:LSRD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LSRD_ECOLI pepstats swissprot:LSRD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LSRD_ECOLI pepwheel swissprot:LSRD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LSRD_ECOLI pepwindow swissprot:LSRD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LSRD_ECOLI sigcleave swissprot:LSRD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LSRD_ECOLI ## Database ID URL or Descriptions # AltName BGLA_ECOLI Phospho-beta-glucosidase A # BioGrid 4263280 18 # CATALYTIC ACTIVITY BGLA_ECOLI 6-phospho-beta-D-glucosyl-(1,4)-D-glucose + H(2)O = D-glucose + D-glucose 6-phosphate. # CAZy GH1 Glycoside Hydrolase Family 1 # EcoGene EG13079 bglA # FUNCTION BGLA_ECOLI Catalyzes the hydrolysis of phosphorylated beta- glucosides into glucose-6-phosphate (G-6-P) and aglycone. It has a high affinity for phosphorylated aromatic beta-glucosides (p- nitrophenyl-beta-glucoside, phenyl beta-glucoside, arbutin), with the exception of phosphorylated salicin, and a low affinity for phosphorylated beta-methyl-glucoside. Apparently, it has only a very limited role in the utilization of external beta-glucosides. {ECO 0000269|PubMed 4576407}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008422 beta-glucosidase activity; IBA:GO_Central. # GO_function GO:0008706 6-phospho-beta-glucosidase activity; IEA:UniProtKB-EC. # GO_function GO:0015926 glucosidase activity; IDA:EcoCyc. # GO_process GO:0005975 carbohydrate metabolic process; IEA:InterPro. # GO_process GO:1901657 glycosyl compound metabolic process; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0008150 biological_process # Gene3D 3.20.20.80 -; 1. # INDUCTION Constituvely expressed. {ECO:0000269|PubMed 4576407}. # IntAct Q46829 5 # InterPro IPR001360 Glyco_hydro_1 # InterPro IPR013781 Glyco_hydro_catalytic_dom # InterPro IPR017853 Glycoside_hydrolase_SF # InterPro IPR018120 Glyco_hydro_1_AS # InterPro IPR033132 Glyco_hydro_1_N_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00010 Glycolysis / Gluconeogenesis # Organism BGLA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10353 PTHR10353 # PATRIC 32121216 VBIEscCol129921_2996 # PDB 2XHY X-ray; 2.30 A; A/B/C/D=1-479 # PIR E65074 E65074 # PRINTS PR00131 GLHYDRLASE1 # PROSITE PS00572 GLYCOSYL_HYDROL_F1_1 # PROSITE PS00653 GLYCOSYL_HYDROL_F1_2 # Pfam PF00232 Glyco_hydro_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BGLA_ECOLI 6-phospho-beta-glucosidase BglA # RefSeq NP_417377 NC_000913.3 # SIMILARITY Belongs to the glycosyl hydrolase 1 family. {ECO 0000305}. # SUBUNIT Homotetramer. {ECO:0000305|PubMed 22393408}. # SUPFAM SSF51445 SSF51445 # eggNOG COG2723 LUCA # eggNOG ENOG4105CS2 Bacteria BLAST swissprot:BGLA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BGLA_ECOLI BioCyc ECOL316407:JW2869-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2869-MONOMER BioCyc EcoCyc:G495-MONOMER http://biocyc.org/getid?id=EcoCyc:G495-MONOMER BioCyc MetaCyc:G495-MONOMER http://biocyc.org/getid?id=MetaCyc:G495-MONOMER COG COG2723 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2723 DIP DIP-9213N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9213N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pone.0032498 http://dx.doi.org/10.1371/journal.pone.0032498 EC_number EC:3.2.1.86 http://www.genome.jp/dbget-bin/www_bget?EC:3.2.1.86 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28375 http://www.ebi.ac.uk/ena/data/view/U28375 ENZYME 3.2.1.86 http://enzyme.expasy.org/EC/3.2.1.86 EchoBASE EB2889 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2889 EcoGene EG13079 http://www.ecogene.org/geneInfo.php?eg_id=EG13079 EnsemblBacteria AAC75939 http://www.ensemblgenomes.org/id/AAC75939 EnsemblBacteria AAC75939 http://www.ensemblgenomes.org/id/AAC75939 EnsemblBacteria BAE76966 http://www.ensemblgenomes.org/id/BAE76966 EnsemblBacteria BAE76966 http://www.ensemblgenomes.org/id/BAE76966 EnsemblBacteria BAE76966 http://www.ensemblgenomes.org/id/BAE76966 EnsemblBacteria b2901 http://www.ensemblgenomes.org/id/b2901 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008422 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008422 GO_function GO:0008706 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008706 GO_function GO:0015926 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015926 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GO_process GO:1901657 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901657 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.20.20.80 http://www.cathdb.info/version/latest/superfamily/3.20.20.80 GeneID 947378 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947378 HOGENOM HOG000088631 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000088631&db=HOGENOM6 InParanoid Q46829 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46829 IntAct Q46829 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46829* IntEnz 3.2.1.86 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.2.1.86 InterPro IPR001360 http://www.ebi.ac.uk/interpro/entry/IPR001360 InterPro IPR013781 http://www.ebi.ac.uk/interpro/entry/IPR013781 InterPro IPR017853 http://www.ebi.ac.uk/interpro/entry/IPR017853 InterPro IPR018120 http://www.ebi.ac.uk/interpro/entry/IPR018120 InterPro IPR033132 http://www.ebi.ac.uk/interpro/entry/IPR033132 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2869 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2869 KEGG_Gene eco:b2901 http://www.genome.jp/dbget-bin/www_bget?eco:b2901 KEGG_Orthology KO:K01223 http://www.genome.jp/dbget-bin/www_bget?KO:K01223 KEGG_Pathway ko00010 http://www.genome.jp/kegg-bin/show_pathway?ko00010 KEGG_Reaction rn:R05134 http://www.genome.jp/dbget-bin/www_bget?rn:R05134 MINT MINT-1322539 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1322539 OMA MRGYYPA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MRGYYPA PANTHER PTHR10353 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10353 PDB 2XHY http://www.ebi.ac.uk/pdbe-srv/view/entry/2XHY PDBsum 2XHY http://www.ebi.ac.uk/pdbsum/2XHY PRINTS PR00131 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00131 PROSITE PS00572 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00572 PROSITE PS00653 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00653 PSORT swissprot:BGLA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BGLA_ECOLI PSORT-B swissprot:BGLA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BGLA_ECOLI PSORT2 swissprot:BGLA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BGLA_ECOLI Pfam PF00232 http://pfam.xfam.org/family/PF00232 Phobius swissprot:BGLA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BGLA_ECOLI PhylomeDB Q46829 http://phylomedb.org/?seqid=Q46829 ProteinModelPortal Q46829 http://www.proteinmodelportal.org/query/uniprot/Q46829 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22393408 http://www.ncbi.nlm.nih.gov/pubmed/22393408 PubMed 4576407 http://www.ncbi.nlm.nih.gov/pubmed/4576407 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417377 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417377 SMR Q46829 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46829 STRING 511145.b2901 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2901&targetmode=cogs STRING COG2723 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2723&targetmode=cogs SUPFAM SSF51445 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51445 UniProtKB BGLA_ECOLI http://www.uniprot.org/uniprot/BGLA_ECOLI UniProtKB-AC Q46829 http://www.uniprot.org/uniprot/Q46829 charge swissprot:BGLA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BGLA_ECOLI eggNOG COG2723 http://eggnogapi.embl.de/nog_data/html/tree/COG2723 eggNOG ENOG4105CS2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CS2 epestfind swissprot:BGLA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BGLA_ECOLI garnier swissprot:BGLA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BGLA_ECOLI helixturnhelix swissprot:BGLA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BGLA_ECOLI hmoment swissprot:BGLA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BGLA_ECOLI iep swissprot:BGLA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BGLA_ECOLI inforesidue swissprot:BGLA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BGLA_ECOLI octanol swissprot:BGLA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BGLA_ECOLI pepcoil swissprot:BGLA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BGLA_ECOLI pepdigest swissprot:BGLA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BGLA_ECOLI pepinfo swissprot:BGLA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BGLA_ECOLI pepnet swissprot:BGLA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BGLA_ECOLI pepstats swissprot:BGLA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BGLA_ECOLI pepwheel swissprot:BGLA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BGLA_ECOLI pepwindow swissprot:BGLA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BGLA_ECOLI sigcleave swissprot:BGLA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BGLA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261748 11 # CATALYTIC ACTIVITY YLAB_ECOLI Cyclic di-3',5'-guanylate + H(2)O = 5'- phosphoguanylyl(3'->5')guanosine. # CDD cd01948 EAL # EcoGene EG14237 ylaB # FUNCTION YLAB_ECOLI May function as a c-di-GMP phosphodiesterase. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria (By similarity). {ECO 0000250}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0071111 cyclic-guanylate-specific phosphodiesterase activity; IEA:UniProtKB-EC. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # Gene3D 3.20.20.450 -; 1. # INDUCTION Expressed during transition into stationary phase, at both 28 and 37 degrees Celsius. Expression is RpoS dependent. {ECO:0000269|PubMed 19332833}. # InterPro IPR001633 EAL_dom # InterPro IPR024744 CSS-motif_dom # Organism YLAB_ECOLI Escherichia coli (strain K12) # PATRIC 32116067 VBIEscCol129921_0475 # PIR H64775 H64775 # PROSITE PS50883 EAL # Pfam PF00563 EAL # Pfam PF12792 CSS-motif # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YLAB_ECOLI Putative cyclic-di-GMP phosphodiesterase YlaB # RefSeq NP_414990 NC_000913.3 # RefSeq WP_001310610 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40212.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Contains 1 EAL domain. {ECO:0000255|PROSITE- ProRule PRU00074}. # SMART SM00052 EAL # SUBCELLULAR LOCATION YLAB_ECOLI Cell inner membrane {ECO 0000305}; Multi- pass membrane protein {ECO 0000305}. # SUPFAM SSF141868 SSF141868 # eggNOG COG4943 LUCA # eggNOG ENOG41066DG Bacteria BLAST swissprot:YLAB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YLAB_ECOLI BioCyc ECOL316407:JW5062-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5062-MONOMER BioCyc EcoCyc:G6252-MONOMER http://biocyc.org/getid?id=EcoCyc:G6252-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1099/mic.0.024257-0 http://dx.doi.org/10.1099/mic.0.024257-0 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.4.52 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.4.52 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 ENZYME 3.1.4.52 http://enzyme.expasy.org/EC/3.1.4.52 EchoBASE EB3988 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3988 EcoGene EG14237 http://www.ecogene.org/geneInfo.php?eg_id=EG14237 EnsemblBacteria AAC73559 http://www.ensemblgenomes.org/id/AAC73559 EnsemblBacteria AAC73559 http://www.ensemblgenomes.org/id/AAC73559 EnsemblBacteria BAE76236 http://www.ensemblgenomes.org/id/BAE76236 EnsemblBacteria BAE76236 http://www.ensemblgenomes.org/id/BAE76236 EnsemblBacteria BAE76236 http://www.ensemblgenomes.org/id/BAE76236 EnsemblBacteria b0457 http://www.ensemblgenomes.org/id/b0457 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0071111 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071111 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 Gene3D 3.20.20.450 http://www.cathdb.info/version/latest/superfamily/3.20.20.450 GeneID 948951 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948951 HOGENOM HOG000117610 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117610&db=HOGENOM6 InParanoid P77473 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77473 IntEnz 3.1.4.52 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.4.52 InterPro IPR001633 http://www.ebi.ac.uk/interpro/entry/IPR001633 InterPro IPR024744 http://www.ebi.ac.uk/interpro/entry/IPR024744 KEGG_Gene ecj:JW5062 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5062 KEGG_Gene eco:b0457 http://www.genome.jp/dbget-bin/www_bget?eco:b0457 OMA SQQHISI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SQQHISI PROSITE PS50883 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50883 PSORT swissprot:YLAB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YLAB_ECOLI PSORT-B swissprot:YLAB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YLAB_ECOLI PSORT2 swissprot:YLAB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YLAB_ECOLI Pfam PF00563 http://pfam.xfam.org/family/PF00563 Pfam PF12792 http://pfam.xfam.org/family/PF12792 Phobius swissprot:YLAB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YLAB_ECOLI PhylomeDB P77473 http://phylomedb.org/?seqid=P77473 ProteinModelPortal P77473 http://www.proteinmodelportal.org/query/uniprot/P77473 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19332833 http://www.ncbi.nlm.nih.gov/pubmed/19332833 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414990 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414990 RefSeq WP_001310610 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001310610 SMART SM00052 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00052 SMR P77473 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77473 STRING 511145.b0457 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0457&targetmode=cogs SUPFAM SSF141868 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF141868 UniProtKB YLAB_ECOLI http://www.uniprot.org/uniprot/YLAB_ECOLI UniProtKB-AC P77473 http://www.uniprot.org/uniprot/P77473 charge swissprot:YLAB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YLAB_ECOLI eggNOG COG4943 http://eggnogapi.embl.de/nog_data/html/tree/COG4943 eggNOG ENOG41066DG http://eggnogapi.embl.de/nog_data/html/tree/ENOG41066DG epestfind swissprot:YLAB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YLAB_ECOLI garnier swissprot:YLAB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YLAB_ECOLI helixturnhelix swissprot:YLAB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YLAB_ECOLI hmoment swissprot:YLAB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YLAB_ECOLI iep swissprot:YLAB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YLAB_ECOLI inforesidue swissprot:YLAB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YLAB_ECOLI octanol swissprot:YLAB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YLAB_ECOLI pepcoil swissprot:YLAB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YLAB_ECOLI pepdigest swissprot:YLAB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YLAB_ECOLI pepinfo swissprot:YLAB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YLAB_ECOLI pepnet swissprot:YLAB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YLAB_ECOLI pepstats swissprot:YLAB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YLAB_ECOLI pepwheel swissprot:YLAB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YLAB_ECOLI pepwindow swissprot:YLAB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YLAB_ECOLI sigcleave swissprot:YLAB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YLAB_ECOLI ## Database ID URL or Descriptions # BRENDA 2.7.13 2026 # BioGrid 4263453 7 # CATALYTIC ACTIVITY ZRAS_ECOLI ATP + protein L-histidine = ADP + protein N- phospho-L-histidine. # CAUTION Was originally thought to be involved in the regulation of the labile hydrogenase activity. {ECO:0000305|PubMed 2666400}. # EcoGene EG10008 zraS # FUNCTION ZRAS_ECOLI Member of the two-component regulatory system ZraS/ZraR. May function as a membrane-associated protein kinase that phosphorylates ZraR in response to high concentrations of zinc or lead in the medium. {ECO 0000269|PubMed 15522865}. # GO_component GO:0005622 intracellular; IEA:GOC. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:EcoliWiki. # GO_function GO:0000155 phosphorelay sensor kinase activity; IMP:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0000160 phosphorelay signal transduction system; IDA:EcoCyc. # GO_process GO:0046777 protein autophosphorylation; IDA:EcoCyc. # GO_process GO:0071284 cellular response to lead ion; IEP:EcoCyc. # GO_process GO:0071294 cellular response to zinc ion; IEP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005622 intracellular # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0004871 signal transducer activity # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # Gene3D 1.10.287.130 -; 1. # Gene3D 3.30.565.10 -; 1. # InterPro IPR003594 HATPase_C # InterPro IPR003661 HisK_dim/P # InterPro IPR004358 Sig_transdc_His_kin-like_C # InterPro IPR005467 His_kinase_dom # InterPro IPR029151 Sensor-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01001 Protein kinases # KEGG_Brite ko02022 M00499 HydH-HydG (metal tolerance) two-component regulatory system # KEGG_Brite ko02022 Two-component system # KEGG_Pathway ko02020 Two-component system # Organism ZRAS_ECOLI Escherichia coli (strain K12) # PATRIC 32123531 VBIEscCol129921_4118 # PIR F65207 F65207 # PRINTS PR00344 BCTRLSENSOR # PROSITE PS50109 HIS_KIN # PTM ZRAS_ECOLI Autophosphorylated. # Pfam PF00512 HisKA # Pfam PF02518 HATPase_c # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ZRAS_ECOLI Sensor protein ZraS # RefSeq NP_418431 NC_000913.3 # RefSeq WP_001211892 NZ_LN832404.1 # SIMILARITY Contains 1 histidine kinase domain. {ECO:0000255|PROSITE-ProRule PRU00107}. # SMART SM00387 HATPase_c # SMART SM00388 HisKA # SUBCELLULAR LOCATION ZRAS_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # SUPFAM SSF103190 SSF103190 # SUPFAM SSF47384 SSF47384 # SUPFAM SSF55874 SSF55874 # eggNOG ENOG4105BZU Bacteria # eggNOG ENOG410XNMH LUCA BLAST swissprot:ZRAS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ZRAS_ECOLI BioCyc ECOL316407:JW3967-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3967-MONOMER BioCyc EcoCyc:HYDH-MONOMER http://biocyc.org/getid?id=EcoCyc:HYDH-MONOMER COG COG0642 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0642 DIP DIP-9981N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9981N DOI 10.1006/jmbi.2000.4451 http://dx.doi.org/10.1006/jmbi.2000.4451 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M410104200 http://dx.doi.org/10.1074/jbc.M410104200 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.13.3 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.13.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M28369 http://www.ebi.ac.uk/ena/data/view/M28369 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.13.3 http://enzyme.expasy.org/EC/2.7.13.3 EchoBASE EB0008 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0008 EcoGene EG10008 http://www.ecogene.org/geneInfo.php?eg_id=EG10008 EnsemblBacteria AAC76977 http://www.ensemblgenomes.org/id/AAC76977 EnsemblBacteria AAC76977 http://www.ensemblgenomes.org/id/AAC76977 EnsemblBacteria BAE77316 http://www.ensemblgenomes.org/id/BAE77316 EnsemblBacteria BAE77316 http://www.ensemblgenomes.org/id/BAE77316 EnsemblBacteria BAE77316 http://www.ensemblgenomes.org/id/BAE77316 EnsemblBacteria b4003 http://www.ensemblgenomes.org/id/b4003 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0000155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000155 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0046777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046777 GO_process GO:0071284 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071284 GO_process GO:0071294 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071294 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0004871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004871 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 1.10.287.130 http://www.cathdb.info/version/latest/superfamily/1.10.287.130 Gene3D 3.30.565.10 http://www.cathdb.info/version/latest/superfamily/3.30.565.10 GeneID 948506 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948506 HOGENOM HOG000126797 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126797&db=HOGENOM6 InParanoid P14377 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P14377 IntAct P14377 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P14377* IntEnz 2.7.13.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.13.3 InterPro IPR003594 http://www.ebi.ac.uk/interpro/entry/IPR003594 InterPro IPR003661 http://www.ebi.ac.uk/interpro/entry/IPR003661 InterPro IPR004358 http://www.ebi.ac.uk/interpro/entry/IPR004358 InterPro IPR005467 http://www.ebi.ac.uk/interpro/entry/IPR005467 InterPro IPR029151 http://www.ebi.ac.uk/interpro/entry/IPR029151 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01001 http://www.genome.jp/dbget-bin/www_bget?ko01001 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Brite ko02022 http://www.genome.jp/dbget-bin/www_bget?ko02022 KEGG_Gene ecj:JW3967 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3967 KEGG_Gene eco:b4003 http://www.genome.jp/dbget-bin/www_bget?eco:b4003 KEGG_Orthology KO:K07709 http://www.genome.jp/dbget-bin/www_bget?KO:K07709 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA QAIFTPY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QAIFTPY PRINTS PR00344 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00344 PROSITE PS50109 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50109 PSORT swissprot:ZRAS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ZRAS_ECOLI PSORT-B swissprot:ZRAS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ZRAS_ECOLI PSORT2 swissprot:ZRAS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ZRAS_ECOLI Pfam PF00512 http://pfam.xfam.org/family/PF00512 Pfam PF02518 http://pfam.xfam.org/family/PF02518 Phobius swissprot:ZRAS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ZRAS_ECOLI ProteinModelPortal P14377 http://www.proteinmodelportal.org/query/uniprot/P14377 PubMed 11243806 http://www.ncbi.nlm.nih.gov/pubmed/11243806 PubMed 15522865 http://www.ncbi.nlm.nih.gov/pubmed/15522865 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2666400 http://www.ncbi.nlm.nih.gov/pubmed/2666400 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418431 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418431 RefSeq WP_001211892 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001211892 SMART SM00387 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00387 SMART SM00388 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00388 SMR P14377 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P14377 STRING 511145.b4003 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4003&targetmode=cogs STRING COG0642 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0642&targetmode=cogs SUPFAM SSF103190 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103190 SUPFAM SSF47384 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47384 SUPFAM SSF55874 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55874 UniProtKB ZRAS_ECOLI http://www.uniprot.org/uniprot/ZRAS_ECOLI UniProtKB-AC P14377 http://www.uniprot.org/uniprot/P14377 charge swissprot:ZRAS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ZRAS_ECOLI eggNOG ENOG4105BZU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZU eggNOG ENOG410XNMH http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNMH epestfind swissprot:ZRAS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ZRAS_ECOLI garnier swissprot:ZRAS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ZRAS_ECOLI helixturnhelix swissprot:ZRAS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ZRAS_ECOLI hmoment swissprot:ZRAS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ZRAS_ECOLI iep swissprot:ZRAS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ZRAS_ECOLI inforesidue swissprot:ZRAS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ZRAS_ECOLI octanol swissprot:ZRAS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ZRAS_ECOLI pepcoil swissprot:ZRAS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ZRAS_ECOLI pepdigest swissprot:ZRAS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ZRAS_ECOLI pepinfo swissprot:ZRAS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ZRAS_ECOLI pepnet swissprot:ZRAS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ZRAS_ECOLI pepstats swissprot:ZRAS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ZRAS_ECOLI pepwheel swissprot:ZRAS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ZRAS_ECOLI pepwindow swissprot:ZRAS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ZRAS_ECOLI sigcleave swissprot:ZRAS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ZRAS_ECOLI ## Database ID URL or Descriptions # BioGrid 4260840 6 # CATALYTIC ACTIVITY YJCC_ECOLI Cyclic di-3',5'-guanylate + H(2)O = 5'- phosphoguanylyl(3'->5')guanosine. # CDD cd01948 EAL # EcoGene EG11938 yjcC # FUNCTION YJCC_ECOLI May function as a c-di-GMP phosphodiesterase. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria. Overexpression reduces biofilm formation. {ECO 0000269|PubMed 19460094}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0071111 cyclic-guanylate-specific phosphodiesterase activity; IEA:UniProtKB-EC. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # Gene3D 3.20.20.450 -; 1. # INDUCTION Expressed during transition into stationary phase, at both 28 and 37 degrees Celsius. Expression is RpoS dependent. {ECO:0000269|PubMed 19332833}. # IntAct P32701 2 # InterPro IPR001633 EAL_dom # InterPro IPR024744 CSS-motif_dom # Organism YJCC_ECOLI Escherichia coli (strain K12) # PATRIC 32123667 VBIEscCol129921_4182 # PIR D65214 D65214 # PROSITE PS50883 EAL # Pfam PF00563 EAL # Pfam PF12792 CSS-motif # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJCC_ECOLI Putative cyclic-di-GMP phosphodiesterase YjcC # RefSeq NP_418485 NC_000913.3 # RefSeq WP_000019548 NZ_LN832404.1 # SIMILARITY Contains 1 EAL domain. {ECO:0000255|PROSITE- ProRule PRU00074}. # SMART SM00052 EAL # SUBCELLULAR LOCATION YJCC_ECOLI Cell inner membrane {ECO 0000305}; Multi- pass membrane protein {ECO 0000305}. # SUPFAM SSF141868 SSF141868 # eggNOG COG4943 LUCA # eggNOG ENOG4108M8H Bacteria BLAST swissprot:YJCC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJCC_ECOLI BioCyc ECOL316407:JW4022-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4022-MONOMER BioCyc EcoCyc:EG11938-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11938-MONOMER DIP DIP-12548N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12548N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1099/mic.0.024257-0 http://dx.doi.org/10.1099/mic.0.024257-0 DOI 10.1111/j.1365-2958.2009.06739.x http://dx.doi.org/10.1111/j.1365-2958.2009.06739.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.4.52 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.4.52 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.4.52 http://enzyme.expasy.org/EC/3.1.4.52 EchoBASE EB1882 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1882 EcoGene EG11938 http://www.ecogene.org/geneInfo.php?eg_id=EG11938 EnsemblBacteria AAC77031 http://www.ensemblgenomes.org/id/AAC77031 EnsemblBacteria AAC77031 http://www.ensemblgenomes.org/id/AAC77031 EnsemblBacteria BAE78063 http://www.ensemblgenomes.org/id/BAE78063 EnsemblBacteria BAE78063 http://www.ensemblgenomes.org/id/BAE78063 EnsemblBacteria BAE78063 http://www.ensemblgenomes.org/id/BAE78063 EnsemblBacteria b4061 http://www.ensemblgenomes.org/id/b4061 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0071111 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071111 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 Gene3D 3.20.20.450 http://www.cathdb.info/version/latest/superfamily/3.20.20.450 GeneID 948568 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948568 HOGENOM HOG000117610 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117610&db=HOGENOM6 InParanoid P32701 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32701 IntAct P32701 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32701* IntEnz 3.1.4.52 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.4.52 InterPro IPR001633 http://www.ebi.ac.uk/interpro/entry/IPR001633 InterPro IPR024744 http://www.ebi.ac.uk/interpro/entry/IPR024744 KEGG_Gene ecj:JW4022 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4022 KEGG_Gene eco:b4061 http://www.genome.jp/dbget-bin/www_bget?eco:b4061 OMA RLIAHFY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RLIAHFY PROSITE PS50883 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50883 PSORT swissprot:YJCC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJCC_ECOLI PSORT-B swissprot:YJCC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJCC_ECOLI PSORT2 swissprot:YJCC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJCC_ECOLI Pfam PF00563 http://pfam.xfam.org/family/PF00563 Pfam PF12792 http://pfam.xfam.org/family/PF12792 Phobius swissprot:YJCC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJCC_ECOLI ProteinModelPortal P32701 http://www.proteinmodelportal.org/query/uniprot/P32701 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19332833 http://www.ncbi.nlm.nih.gov/pubmed/19332833 PubMed 19460094 http://www.ncbi.nlm.nih.gov/pubmed/19460094 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418485 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418485 RefSeq WP_000019548 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000019548 SMART SM00052 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00052 SMR P32701 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32701 STRING 511145.b4061 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4061&targetmode=cogs SUPFAM SSF141868 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF141868 UniProtKB YJCC_ECOLI http://www.uniprot.org/uniprot/YJCC_ECOLI UniProtKB-AC P32701 http://www.uniprot.org/uniprot/P32701 charge swissprot:YJCC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJCC_ECOLI eggNOG COG4943 http://eggnogapi.embl.de/nog_data/html/tree/COG4943 eggNOG ENOG4108M8H http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108M8H epestfind swissprot:YJCC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJCC_ECOLI garnier swissprot:YJCC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJCC_ECOLI helixturnhelix swissprot:YJCC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJCC_ECOLI hmoment swissprot:YJCC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJCC_ECOLI iep swissprot:YJCC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJCC_ECOLI inforesidue swissprot:YJCC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJCC_ECOLI octanol swissprot:YJCC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJCC_ECOLI pepcoil swissprot:YJCC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJCC_ECOLI pepdigest swissprot:YJCC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJCC_ECOLI pepinfo swissprot:YJCC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJCC_ECOLI pepnet swissprot:YJCC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJCC_ECOLI pepstats swissprot:YJCC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJCC_ECOLI pepwheel swissprot:YJCC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJCC_ECOLI pepwindow swissprot:YJCC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJCC_ECOLI sigcleave swissprot:YJCC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJCC_ECOLI ## Database ID URL or Descriptions # AltName LAMB_ECOLI Lambda receptor protein # AltName LAMB_ECOLI Maltose-inducible porin # BioGrid 4262663 252 # CDD cd01346 Maltoporin-like # EcoGene EG10528 lamB # FUNCTION LAMB_ECOLI Involved in the transport of maltose and maltodextrins, indispensable for translocation of dextrins containing more than three glucosyl moieties. A hydrophobic path ("greasy slide") of aromatic residues serves to guide and select the sugars for transport through the channel. Also acts as a receptor for several bacteriophages including lambda. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_component GO:0045203 integral component of cell outer membrane; IDA:EcoCyc. # GO_component GO:0046930 pore complex; IDA:EcoCyc. # GO_function GO:0001618 virus receptor activity; IEA:UniProtKB-KW. # GO_function GO:0015288 porin activity; IDA:CACAO. # GO_function GO:0015481 maltose transporting porin activity; IEA:InterPro. # GO_function GO:0042958 maltodextrin transmembrane transporter activity; IDA:EcoCyc. # GO_process GO:0006811 ion transport; IEA:UniProtKB-KW. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0042956 maltodextrin transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0006950 response to stress # Gene3D 2.40.170.10 -; 1. # HAMAP MF_01301 LamB # INDUCTION LAMB_ECOLI By maltose. # INTERACTION LAMB_ECOLI P10408 secA; NbExp=3; IntAct=EBI-371309, EBI-543213; # IntAct P02943 2 # InterPro IPR003192 Porin_LamB # InterPro IPR023738 Maltoporin # KEGG_Brite ko02000 Transporters # Organism LAMB_ECOLI Escherichia coli (strain K12) # PATRIC 32123605 VBIEscCol129921_4151 # PDB 1AF6 X-ray; 2.40 A; A/B/C=26-446 # PDB 1MAL X-ray; 3.10 A; A/B/C=26-446 # PDB 1MPM X-ray; 2.60 A; A/B/C=26-446 # PDB 1MPN X-ray; 3.20 A; A/B/C=26-446 # PDB 1MPO X-ray; 2.80 A; A/B/C=26-446 # PDB 1MPQ X-ray; 3.00 A; A/B/C=26-446 # PIR A03443 QRECL # Pfam PF02264 LamB # ProDom PD008788 Porin_LamB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LAMB_ECOLI Maltoporin # RefSeq NP_418460 NC_000913.3 # RefSeq WP_000973663 NZ_LN832404.1 # SIMILARITY Belongs to the porin LamB (TC 1.B.3) family. {ECO 0000305}. # SUBCELLULAR LOCATION LAMB_ECOLI Cell outer membrane {ECO 0000269|PubMed 16079137}; Multi-pass membrane protein {ECO 0000269|PubMed 16079137}. # SUBUNIT Homotrimer formed of three 18-stranded antiparallel beta- barrels, containing three independent channels. {ECO:0000269|PubMed 16079137}. # TCDB 1.B.3.1 the sugar porin (sp) family # eggNOG COG4580 LUCA # eggNOG ENOG4108KDD Bacteria BLAST swissprot:LAMB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LAMB_ECOLI BioCyc ECOL316407:JW3996-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3996-MONOMER BioCyc EcoCyc:EG10528-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10528-MONOMER BioCyc MetaCyc:EG10528-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10528-MONOMER COG COG4580 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4580 DIP DIP-10082N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10082N DOI 10.1006/jmbi.1997.1224 http://dx.doi.org/10.1006/jmbi.1997.1224 DOI 10.1016/0092-8674(81)90392-5 http://dx.doi.org/10.1016/0092-8674(81)90392-5 DOI 10.1016/0378-1119(87)90018-7 http://dx.doi.org/10.1016/0378-1119(87)90018-7 DOI 10.1016/S0969-2126(96)00016-0 http://dx.doi.org/10.1016/S0969-2126(96)00016-0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.77.5.2621 http://dx.doi.org/10.1073/pnas.77.5.2621 DOI 10.1074/jbc.M506479200 http://dx.doi.org/10.1074/jbc.M506479200 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1093/protein/14.11.943 http://dx.doi.org/10.1093/protein/14.11.943 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1126/science.7824948 http://dx.doi.org/10.1126/science.7824948 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01648 http://www.ebi.ac.uk/ena/data/view/J01648 EMBL M16643 http://www.ebi.ac.uk/ena/data/view/M16643 EMBL M24997 http://www.ebi.ac.uk/ena/data/view/M24997 EMBL M26131 http://www.ebi.ac.uk/ena/data/view/M26131 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00297 http://www.ebi.ac.uk/ena/data/view/V00297 EMBL V00298 http://www.ebi.ac.uk/ena/data/view/V00298 EchoBASE EB0523 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0523 EcoGene EG10528 http://www.ecogene.org/geneInfo.php?eg_id=EG10528 EnsemblBacteria AAC77006 http://www.ensemblgenomes.org/id/AAC77006 EnsemblBacteria AAC77006 http://www.ensemblgenomes.org/id/AAC77006 EnsemblBacteria BAE78038 http://www.ensemblgenomes.org/id/BAE78038 EnsemblBacteria BAE78038 http://www.ensemblgenomes.org/id/BAE78038 EnsemblBacteria BAE78038 http://www.ensemblgenomes.org/id/BAE78038 EnsemblBacteria b4036 http://www.ensemblgenomes.org/id/b4036 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0045203 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045203 GO_component GO:0046930 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046930 GO_function GO:0001618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001618 GO_function GO:0015288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015288 GO_function GO:0015481 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015481 GO_function GO:0042958 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042958 GO_process GO:0006811 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0042956 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042956 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 2.40.170.10 http://www.cathdb.info/version/latest/superfamily/2.40.170.10 GeneID 948548 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948548 HAMAP MF_01301 http://hamap.expasy.org/unirule/MF_01301 HOGENOM HOG000218083 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218083&db=HOGENOM6 IntAct P02943 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P02943* InterPro IPR003192 http://www.ebi.ac.uk/interpro/entry/IPR003192 InterPro IPR023738 http://www.ebi.ac.uk/interpro/entry/IPR023738 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3996 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3996 KEGG_Gene eco:b4036 http://www.genome.jp/dbget-bin/www_bget?eco:b4036 KEGG_Orthology KO:K02024 http://www.genome.jp/dbget-bin/www_bget?KO:K02024 OMA YNKFVLQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YNKFVLQ PDB 1AF6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1AF6 PDB 1MAL http://www.ebi.ac.uk/pdbe-srv/view/entry/1MAL PDB 1MPM http://www.ebi.ac.uk/pdbe-srv/view/entry/1MPM PDB 1MPN http://www.ebi.ac.uk/pdbe-srv/view/entry/1MPN PDB 1MPO http://www.ebi.ac.uk/pdbe-srv/view/entry/1MPO PDB 1MPQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1MPQ PDBsum 1AF6 http://www.ebi.ac.uk/pdbsum/1AF6 PDBsum 1MAL http://www.ebi.ac.uk/pdbsum/1MAL PDBsum 1MPM http://www.ebi.ac.uk/pdbsum/1MPM PDBsum 1MPN http://www.ebi.ac.uk/pdbsum/1MPN PDBsum 1MPO http://www.ebi.ac.uk/pdbsum/1MPO PDBsum 1MPQ http://www.ebi.ac.uk/pdbsum/1MPQ PSORT swissprot:LAMB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LAMB_ECOLI PSORT-B swissprot:LAMB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LAMB_ECOLI PSORT2 swissprot:LAMB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LAMB_ECOLI Pfam PF02264 http://pfam.xfam.org/family/PF02264 Phobius swissprot:LAMB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LAMB_ECOLI ProteinModelPortal P02943 http://www.proteinmodelportal.org/query/uniprot/P02943 PubMed 11742115 http://www.ncbi.nlm.nih.gov/pubmed/11742115 PubMed 16079137 http://www.ncbi.nlm.nih.gov/pubmed/16079137 PubMed 161974 http://www.ncbi.nlm.nih.gov/pubmed/161974 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1702781 http://www.ncbi.nlm.nih.gov/pubmed/1702781 PubMed 1988451 http://www.ncbi.nlm.nih.gov/pubmed/1988451 PubMed 2832377 http://www.ncbi.nlm.nih.gov/pubmed/2832377 PubMed 3301537 http://www.ncbi.nlm.nih.gov/pubmed/3301537 PubMed 6086106 http://www.ncbi.nlm.nih.gov/pubmed/6086106 PubMed 6446717 http://www.ncbi.nlm.nih.gov/pubmed/6446717 PubMed 7824948 http://www.ncbi.nlm.nih.gov/pubmed/7824948 PubMed 7925308 http://www.ncbi.nlm.nih.gov/pubmed/7925308 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 8805519 http://www.ncbi.nlm.nih.gov/pubmed/8805519 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9299337 http://www.ncbi.nlm.nih.gov/pubmed/9299337 RefSeq NP_418460 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418460 RefSeq WP_000973663 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000973663 SMR P02943 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P02943 STRING 511145.b4036 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4036&targetmode=cogs STRING COG4580 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4580&targetmode=cogs TCDB 1.B.3.1 http://www.tcdb.org/search/result.php?tc=1.B.3.1 UniProtKB LAMB_ECOLI http://www.uniprot.org/uniprot/LAMB_ECOLI UniProtKB-AC P02943 http://www.uniprot.org/uniprot/P02943 charge swissprot:LAMB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LAMB_ECOLI eggNOG COG4580 http://eggnogapi.embl.de/nog_data/html/tree/COG4580 eggNOG ENOG4108KDD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108KDD epestfind swissprot:LAMB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LAMB_ECOLI garnier swissprot:LAMB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LAMB_ECOLI helixturnhelix swissprot:LAMB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LAMB_ECOLI hmoment swissprot:LAMB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LAMB_ECOLI iep swissprot:LAMB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LAMB_ECOLI inforesidue swissprot:LAMB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LAMB_ECOLI octanol swissprot:LAMB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LAMB_ECOLI pepcoil swissprot:LAMB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LAMB_ECOLI pepdigest swissprot:LAMB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LAMB_ECOLI pepinfo swissprot:LAMB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LAMB_ECOLI pepnet swissprot:LAMB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LAMB_ECOLI pepstats swissprot:LAMB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LAMB_ECOLI pepwheel swissprot:LAMB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LAMB_ECOLI pepwindow swissprot:LAMB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LAMB_ECOLI sigcleave swissprot:LAMB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LAMB_ECOLI ## Database ID URL or Descriptions # AltName Acylphosphate phosphohydrolase {ECO:0000255|HAMAP-Rule MF_01450} # BIOPHYSICOCHEMICAL PROPERTIES ACYP_ECOLI Kinetic parameters KM=0.54 mM for benzoylphosphate {ECO 0000269|PubMed 17134700}; pH dependence Optimum pH is 5.2-6.5. {ECO 0000269|PubMed 17134700}; Temperature dependence Thermostable. Retains 85-90 % of its activity after 3 hours of incubation at 90 degrees Celsius. {ECO 0000269|PubMed 17134700}; # BRENDA 3.6.1 2026 # BioGrid 4260041 6 # CATALYTIC ACTIVITY ACYP_ECOLI An acylphosphate + H(2)O = a carboxylate + phosphate. {ECO 0000255|HAMAP-Rule MF_01450, ECO 0000269|PubMed 17134700}. # EcoGene EG13726 yccX # GO_function GO:0003998 acylphosphatase activity; IDA:EcoCyc. # GO_process GO:0009408 response to heat; IMP:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006950 response to stress # HAMAP MF_01450 Acylphosphatase_entero # IntAct P0AB65 4 # InterPro IPR001792 Acylphosphatase-like_dom # InterPro IPR017968 Acylphosphatase_CS # InterPro IPR020456 Acylphosphatase # InterPro IPR028627 Acylphosphatase_bac # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00620 Pyruvate metabolism # KEGG_Pathway ko00627 Aminobenzoate degradation # MISCELLANEOUS ACYP_ECOLI Has a considerably reduced catalytic efficiency compared to other mesophilic acylphosphatases. Shows a considerable resistance against urea denaturation since the full enzymatic activity is maintained in the presence of urea concentrations approaching 6.0 M and that only a slight decreae of 10-15 % was observed with higher urea concentrations. # Organism ACYP_ECOLI Escherichia coli (strain K12) # PATRIC 32117157 VBIEscCol129921_1003 # PDB 2GV1 NMR; -; A=1-92 # PIR G64837 G64837 # PRINTS PR00112 ACYLPHPHTASE # PROSITE PS00150 ACYLPHOSPHATASE_1 # PROSITE PS00151 ACYLPHOSPHATASE_2 # PROSITE PS51160 ACYLPHOSPHATASE_3 # Pfam PF00708 Acylphosphatase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Acylphosphatase {ECO:0000255|HAMAP-Rule MF_01450} # RefSeq NP_415488 NC_000913.3 # RefSeq WP_000048252 NZ_LN832404.1 # SIMILARITY Belongs to the acylphosphatase family. {ECO:0000255|HAMAP-Rule MF_01450}. # SIMILARITY Contains 1 acylphosphatase-like domain. {ECO:0000255|HAMAP-Rule MF_01450}. # SUPFAM SSF54975 SSF54975 # eggNOG COG1254 LUCA # eggNOG ENOG4105VSY Bacteria BLAST swissprot:ACYP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ACYP_ECOLI BioCyc ECOL316407:JW5131-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5131-MONOMER BioCyc EcoCyc:G6502-MONOMER http://biocyc.org/getid?id=EcoCyc:G6502-MONOMER BioCyc MetaCyc:G6502-MONOMER http://biocyc.org/getid?id=MetaCyc:G6502-MONOMER COG COG1254 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1254 DIP DIP-11502N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11502N DOI 10.1007/s10858-006-9073-2 http://dx.doi.org/10.1007/s10858-006-9073-2 DOI 10.1016/j.febslet.2006.11.033 http://dx.doi.org/10.1016/j.febslet.2006.11.033 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.1.7 {ECO:0000255|HAMAP-Rule:MF_01450} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.1.7 {ECO:0000255|HAMAP-Rule:MF_01450} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.6.1.7 {ECO:0000255|HAMAP-Rule:MF_01450} http://enzyme.expasy.org/EC/3.6.1.7 {ECO:0000255|HAMAP-Rule:MF_01450} EchoBASE EB3490 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3490 EcoGene EG13726 http://www.ecogene.org/geneInfo.php?eg_id=EG13726 EnsemblBacteria AAC74054 http://www.ensemblgenomes.org/id/AAC74054 EnsemblBacteria AAC74054 http://www.ensemblgenomes.org/id/AAC74054 EnsemblBacteria BAA35733 http://www.ensemblgenomes.org/id/BAA35733 EnsemblBacteria BAA35733 http://www.ensemblgenomes.org/id/BAA35733 EnsemblBacteria BAA35733 http://www.ensemblgenomes.org/id/BAA35733 EnsemblBacteria b0968 http://www.ensemblgenomes.org/id/b0968 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003998 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003998 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 945304 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945304 HAMAP MF_01450 http://hamap.expasy.org/unirule/MF_01450 HOGENOM HOG000292686 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000292686&db=HOGENOM6 InParanoid P0AB65 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AB65 IntAct P0AB65 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AB65* IntEnz 3.6.1.7 {ECO:0000255|HAMAP-Rule:MF_01450} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.1.7 {ECO:0000255|HAMAP-Rule:MF_01450} InterPro IPR001792 http://www.ebi.ac.uk/interpro/entry/IPR001792 InterPro IPR017968 http://www.ebi.ac.uk/interpro/entry/IPR017968 InterPro IPR020456 http://www.ebi.ac.uk/interpro/entry/IPR020456 InterPro IPR028627 http://www.ebi.ac.uk/interpro/entry/IPR028627 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5131 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5131 KEGG_Gene eco:b0968 http://www.genome.jp/dbget-bin/www_bget?eco:b0968 KEGG_Orthology KO:K01512 http://www.genome.jp/dbget-bin/www_bget?KO:K01512 KEGG_Pathway ko00620 http://www.genome.jp/kegg-bin/show_pathway?ko00620 KEGG_Pathway ko00627 http://www.genome.jp/kegg-bin/show_pathway?ko00627 KEGG_Reaction rn:R00317 http://www.genome.jp/dbget-bin/www_bget?rn:R00317 KEGG_Reaction rn:R01421 http://www.genome.jp/dbget-bin/www_bget?rn:R01421 KEGG_Reaction rn:R01515 http://www.genome.jp/dbget-bin/www_bget?rn:R01515 OMA MIKSCHT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MIKSCHT PDB 2GV1 http://www.ebi.ac.uk/pdbe-srv/view/entry/2GV1 PDBsum 2GV1 http://www.ebi.ac.uk/pdbsum/2GV1 PRINTS PR00112 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00112 PROSITE PS00150 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00150 PROSITE PS00151 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00151 PROSITE PS51160 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51160 PSORT swissprot:ACYP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ACYP_ECOLI PSORT-B swissprot:ACYP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ACYP_ECOLI PSORT2 swissprot:ACYP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ACYP_ECOLI Pfam PF00708 http://pfam.xfam.org/family/PF00708 Phobius swissprot:ACYP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ACYP_ECOLI PhylomeDB P0AB65 http://phylomedb.org/?seqid=P0AB65 ProteinModelPortal P0AB65 http://www.proteinmodelportal.org/query/uniprot/P0AB65 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17021943 http://www.ncbi.nlm.nih.gov/pubmed/17021943 PubMed 17134700 http://www.ncbi.nlm.nih.gov/pubmed/17134700 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415488 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415488 RefSeq WP_000048252 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000048252 SMR P0AB65 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AB65 STRING 511145.b0968 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0968&targetmode=cogs STRING COG1254 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1254&targetmode=cogs SUPFAM SSF54975 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54975 UniProtKB ACYP_ECOLI http://www.uniprot.org/uniprot/ACYP_ECOLI UniProtKB-AC P0AB65 http://www.uniprot.org/uniprot/P0AB65 charge swissprot:ACYP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ACYP_ECOLI eggNOG COG1254 http://eggnogapi.embl.de/nog_data/html/tree/COG1254 eggNOG ENOG4105VSY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VSY epestfind swissprot:ACYP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ACYP_ECOLI garnier swissprot:ACYP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ACYP_ECOLI helixturnhelix swissprot:ACYP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ACYP_ECOLI hmoment swissprot:ACYP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ACYP_ECOLI iep swissprot:ACYP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ACYP_ECOLI inforesidue swissprot:ACYP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ACYP_ECOLI octanol swissprot:ACYP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ACYP_ECOLI pepcoil swissprot:ACYP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ACYP_ECOLI pepdigest swissprot:ACYP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ACYP_ECOLI pepinfo swissprot:ACYP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ACYP_ECOLI pepnet swissprot:ACYP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ACYP_ECOLI pepstats swissprot:ACYP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ACYP_ECOLI pepwheel swissprot:ACYP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ACYP_ECOLI pepwindow swissprot:ACYP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ACYP_ECOLI sigcleave swissprot:ACYP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ACYP_ECOLI ## Database ID URL or Descriptions # AltName INSB2_ECOLI IS1b # EcoGene EG40002 insB2 # FUNCTION INSB2_ECOLI Absolutely required for transposition of IS1. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IMP:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # InterPro IPR005063 Transposase_27 # Organism INSB2_ECOLI Escherichia coli (strain K12) # Pfam PF03400 DDE_Tnp_IS1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSB2_ECOLI Insertion element IS1 2 protein InsB # RefSeq NP_414798 NC_000913.3 # RefSeq NP_414808 NC_000913.3 # RefSeq WP_001119292 NZ_LN832404.1 # SIMILARITY Belongs to the transposase 27 family. {ECO 0000305}. # eggNOG COG1662 LUCA # eggNOG ENOG4108MBK Bacteria BLAST swissprot:INSB2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSB2_ECOLI BioCyc EcoCyc:G6138-MONOMER http://biocyc.org/getid?id=EcoCyc:G6138-MONOMER COG COG1662 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1662 DOI 10.1016/0378-1119(91)90096-T http://dx.doi.org/10.1016/0378-1119(91)90096-T DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L20943 http://www.ebi.ac.uk/ena/data/view/L20943 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EchoBASE EB4705 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4705 EcoGene EG40002 http://www.ecogene.org/geneInfo.php?eg_id=EG40002 EnsemblBacteria AAC73367 http://www.ensemblgenomes.org/id/AAC73367 EnsemblBacteria AAC73367 http://www.ensemblgenomes.org/id/AAC73367 EnsemblBacteria BAE76050 http://www.ensemblgenomes.org/id/BAE76050 EnsemblBacteria BAE76050 http://www.ensemblgenomes.org/id/BAE76050 EnsemblBacteria BAE76050 http://www.ensemblgenomes.org/id/BAE76050 EnsemblBacteria b0264 http://www.ensemblgenomes.org/id/b0264 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GeneID 944950 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944950 GeneID 947698 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947698 HOGENOM HOG000036821 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000036821&db=HOGENOM6 InParanoid P0CF26 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CF26 InterPro IPR005063 http://www.ebi.ac.uk/interpro/entry/IPR005063 KEGG_Gene ecj:JW0256 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0256 KEGG_Gene eco:b0264 http://www.genome.jp/dbget-bin/www_bget?eco:b0264 KEGG_Gene eco:b0274 http://www.genome.jp/dbget-bin/www_bget?eco:b0274 KEGG_Orthology KO:K07480 http://www.genome.jp/dbget-bin/www_bget?KO:K07480 PSORT swissprot:INSB2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSB2_ECOLI PSORT-B swissprot:INSB2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSB2_ECOLI PSORT2 swissprot:INSB2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSB2_ECOLI Pfam PF03400 http://pfam.xfam.org/family/PF03400 Phobius swissprot:INSB2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSB2_ECOLI PhylomeDB P0CF26 http://phylomedb.org/?seqid=P0CF26 ProteinModelPortal P0CF26 http://www.proteinmodelportal.org/query/uniprot/P0CF26 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1849492 http://www.ncbi.nlm.nih.gov/pubmed/1849492 PubMed 8113168 http://www.ncbi.nlm.nih.gov/pubmed/8113168 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414798 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414798 RefSeq NP_414808 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414808 RefSeq WP_001119292 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001119292 STRING 511145.b0274 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0274&targetmode=cogs STRING COG1662 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1662&targetmode=cogs UniProtKB INSB2_ECOLI http://www.uniprot.org/uniprot/INSB2_ECOLI UniProtKB-AC P0CF26 http://www.uniprot.org/uniprot/P0CF26 charge swissprot:INSB2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSB2_ECOLI eggNOG COG1662 http://eggnogapi.embl.de/nog_data/html/tree/COG1662 eggNOG ENOG4108MBK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MBK epestfind swissprot:INSB2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSB2_ECOLI garnier swissprot:INSB2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSB2_ECOLI helixturnhelix swissprot:INSB2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSB2_ECOLI hmoment swissprot:INSB2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSB2_ECOLI iep swissprot:INSB2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSB2_ECOLI inforesidue swissprot:INSB2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSB2_ECOLI octanol swissprot:INSB2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSB2_ECOLI pepcoil swissprot:INSB2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSB2_ECOLI pepdigest swissprot:INSB2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSB2_ECOLI pepinfo swissprot:INSB2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSB2_ECOLI pepnet swissprot:INSB2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSB2_ECOLI pepstats swissprot:INSB2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSB2_ECOLI pepwheel swissprot:INSB2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSB2_ECOLI pepwindow swissprot:INSB2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSB2_ECOLI sigcleave swissprot:INSB2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSB2_ECOLI ## Database ID URL or Descriptions # EcoGene EG10916 rpsQ # FUNCTION RS17_ECOLI One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. Also plays a role in translational accuracy; neamine-resistant ribosomes show reduced neamine-induced misreading in vitro. # GO_component GO:0022627 cytosolic small ribosomal subunit; IDA:EcoliWiki. # GO_function GO:0003735 structural constituent of ribosome; IBA:GO_Central. # GO_function GO:0019843 rRNA binding; IDA:EcoliWiki. # GO_function GO:0070181 small ribosomal subunit rRNA binding; IDA:EcoliWiki. # GO_process GO:0006412 translation; IBA:GO_Central. # GO_process GO:0046677 response to antibiotic; IMP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_function GO:0019843 rRNA binding # GOslim_process GO:0006412 translation # GOslim_process GO:0008150 biological_process # HAMAP MF_01345_B Ribosomal_S17_B # InterPro IPR000266 Ribosomal_S17/S11 # InterPro IPR012340 NA-bd_OB-fold # InterPro IPR019979 Ribosomal_S17_CS # InterPro IPR019984 Ribosomal_S17_bac-type # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 M00179 Ribosome, archaea # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=9573.0; Method=MALDI; Range=2-84; Evidence={ECO:0000269|PubMed 10094780}; # MISCELLANEOUS RS17_ECOLI The strain missing both S17 and L29 grows very slowly and has a rather unstable temperature-sensitive phenotype. # Organism RS17_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10744 PTHR10744 # PATRIC 32122054 VBIEscCol129921_3404 # PDB 1EG0 EM; 11.50 A; G=2-84 # PDB 1M5G Model; -; Q=4-84 # PDB 2YKR EM; 9.80 A; Q=4-83 # PDB 3J9Y EM; 3.90 A; q=1-84 # PDB 3J9Z EM; 3.60 A; SQ=2-84 # PDB 3JA1 EM; 3.60 A; SQ=2-84 # PDB 3JBU EM; 3.64 A; Q=1-84 # PDB 3JBV EM; 3.32 A; Q=1-84 # PDB 3JCD EM; 3.70 A; q=1-84 # PDB 3JCE EM; 3.20 A; q=1-84 # PDB 3JCJ EM; 3.70 A; x=1-84 # PDB 3JCN EM; 4.60 A; r=1-84 # PDB 4A2I EM; 16.50 A; Q=4-83 # PDB 4ADV EM; 13.50 A; Q=2-84 # PDB 4U1U X-ray; 2.95 A; AQ/CQ=4-83 # PDB 4U1V X-ray; 3.00 A; AQ/CQ=4-83 # PDB 4U20 X-ray; 2.90 A; AQ/CQ=4-83 # PDB 4U24 X-ray; 2.90 A; AQ/CQ=4-83 # PDB 4U25 X-ray; 2.90 A; AQ/CQ=4-83 # PDB 4U26 X-ray; 2.80 A; AQ/CQ=4-83 # PDB 4U27 X-ray; 2.80 A; AQ/CQ=4-83 # PDB 4V47 EM; 12.30 A; BQ=2-84 # PDB 4V48 EM; 11.50 A; BQ=2-84 # PDB 4V4H X-ray; 3.46 A; AQ/CQ=1-84 # PDB 4V4Q X-ray; 3.46 A; AQ/CQ=2-84 # PDB 4V4V EM; 15.00 A; AQ=6-84 # PDB 4V4W EM; 15.00 A; AQ=6-84 # PDB 4V50 X-ray; 3.22 A; AQ/CQ=2-84 # PDB 4V52 X-ray; 3.21 A; AQ/CQ=2-84 # PDB 4V53 X-ray; 3.54 A; AQ/CQ=2-84 # PDB 4V54 X-ray; 3.30 A; AQ/CQ=2-84 # PDB 4V55 X-ray; 4.00 A; AQ/CQ=2-84 # PDB 4V56 X-ray; 3.93 A; AQ/CQ=2-84 # PDB 4V57 X-ray; 3.50 A; AQ/CQ=2-84 # PDB 4V5B X-ray; 3.74 A; BQ/DQ=2-84 # PDB 4V5H EM; 5.80 A; AQ=4-83 # PDB 4V5Y X-ray; 4.45 A; AQ/CQ=2-84 # PDB 4V64 X-ray; 3.50 A; AQ/CQ=2-84 # PDB 4V65 EM; 9.00 A; AJ=1-84 # PDB 4V66 EM; 9.00 A; AJ=1-84 # PDB 4V69 EM; 6.70 A; AQ=4-83 # PDB 4V6C X-ray; 3.19 A; AQ/CQ=1-84 # PDB 4V6D X-ray; 3.81 A; AQ/CQ=1-84 # PDB 4V6E X-ray; 3.71 A; AQ/CQ=1-84 # PDB 4V6K EM; 8.25 A; BU=1-84 # PDB 4V6L EM; 13.20 A; AU=1-84 # PDB 4V6M EM; 7.10 A; AQ=2-84 # PDB 4V6N EM; 12.10 A; BT=2-84 # PDB 4V6O EM; 14.70 A; AT=2-84 # PDB 4V6P EM; 13.50 A; AT=2-84 # PDB 4V6Q EM; 11.50 A; AT=2-84 # PDB 4V6R EM; 11.50 A; AT=2-84 # PDB 4V6S EM; 13.10 A; BS=2-84 # PDB 4V6T EM; 8.30 A; AQ=4-83 # PDB 4V6V EM; 9.80 A; AQ=2-84 # PDB 4V6Y EM; 12.00 A; AQ=4-83 # PDB 4V6Z EM; 12.00 A; AQ=4-83 # PDB 4V70 EM; 17.00 A; AQ=4-83 # PDB 4V71 EM; 20.00 A; AQ=4-83 # PDB 4V72 EM; 13.00 A; AQ=4-83 # PDB 4V73 EM; 15.00 A; AQ=4-83 # PDB 4V74 EM; 17.00 A; AQ=4-83 # PDB 4V75 EM; 12.00 A; AQ=4-83 # PDB 4V76 EM; 17.00 A; AQ=4-83 # PDB 4V77 EM; 17.00 A; AQ=4-83 # PDB 4V78 EM; 20.00 A; AQ=4-83 # PDB 4V79 EM; 15.00 A; AQ=4-83 # PDB 4V7A EM; 9.00 A; AQ=4-83 # PDB 4V7B EM; 6.80 A; AQ=1-84 # PDB 4V7C EM; 7.60 A; AQ=2-84 # PDB 4V7D EM; 7.60 A; BQ=2-84 # PDB 4V7I EM; 9.60 A; BQ=1-84 # PDB 4V7S X-ray; 3.25 A; AQ/CQ=4-83 # PDB 4V7T X-ray; 3.19 A; AQ/CQ=4-83 # PDB 4V7U X-ray; 3.10 A; AQ/CQ=4-83 # PDB 4V7V X-ray; 3.29 A; AQ/CQ=4-83 # PDB 4V85 X-ray; 3.20 A; Q=1-84 # PDB 4V89 X-ray; 3.70 A; AQ=1-84 # PDB 4V9C X-ray; 3.30 A; AQ/CQ=1-84 # PDB 4V9D X-ray; 3.00 A; AQ/BQ=4-83 # PDB 4V9O X-ray; 2.90 A; BQ/DQ/FQ/HQ=1-84 # PDB 4V9P X-ray; 2.90 A; BQ/DQ/FQ/HQ=1-84 # PDB 4WF1 X-ray; 3.09 A; AQ/CQ=4-83 # PDB 4WOI X-ray; 3.00 A; AQ/DQ=1-84 # PDB 4WWW X-ray; 3.10 A; QQ/XQ=4-83 # PDB 4YBB X-ray; 2.10 A; AQ/BQ=4-83 # PDB 5AFI EM; 2.90 A; q=1-84 # PDB 5IQR EM; 3.00 A; v=1-84 # PDB 5IT8 X-ray; 3.12 A; AQ/BQ=4-83 # PDB 5J5B X-ray; 2.80 A; AQ/BQ=4-83 # PDB 5J7L X-ray; 3.00 A; AQ/BQ=4-83 # PDB 5J88 X-ray; 3.32 A; AQ/BQ=4-83 # PDB 5J8A X-ray; 3.10 A; AQ/BQ=4-83 # PDB 5J91 X-ray; 2.96 A; AQ/BQ=4-83 # PDB 5JC9 X-ray; 3.03 A; AQ/BQ=4-83 # PDB 5JTE EM; 3.60 A; AQ=1-84 # PDB 5JU8 EM; 3.60 A; AQ=1-84 # PDB 5KCR EM; 3.60 A; 1q=1-84 # PDB 5KCS EM; 3.90 A; 1q=1-84 # PDB 5KPS EM; 3.90 A; 22=1-84 # PDB 5KPV EM; 4.10 A; 21=1-84 # PDB 5KPW EM; 3.90 A; 21=1-84 # PDB 5KPX EM; 3.90 A; 21=1-84 # PDB 5L3P EM; 3.70 A; q=1-84 # PIR A37519 R3EC17 # PRINTS PR00973 RIBOSOMALS17 # PROSITE PS00056 RIBOSOMAL_S17 # Pfam PF00366 Ribosomal_S17 # ProDom PD001295 Ribosomal_S17 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 30S ribosomal protein S17 {ECO:0000255|HAMAP-Rule MF_01345} # RefSeq NP_417770 NC_000913.3 # RefSeq WP_000130100 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein S17P family. {ECO:0000255|HAMAP-Rule MF_01345}. # SUBUNIT RS17_ECOLI Part of the 30S ribosomal subunit. # SUPFAM SSF50249 SSF50249 # TIGRFAMs TIGR03635 uS17_bact # eggNOG COG0186 LUCA BLAST swissprot:RS17_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RS17_ECOLI BioCyc ECOL316407:JW3273-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3273-MONOMER BioCyc EcoCyc:EG10916-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10916-MONOMER BioCyc MetaCyc:EG10916-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10916-MONOMER COG COG0186 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0186 DIP DIP-47952N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47952N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1007/BF00274010 http://dx.doi.org/10.1007/BF00274010 DOI 10.1016/0014-5793(78)80127-6 http://dx.doi.org/10.1016/0014-5793(78)80127-6 DOI 10.1016/0022-2836(76)90124-8 http://dx.doi.org/10.1016/0022-2836(76)90124-8 DOI 10.1016/0092-8674(78)90096-X http://dx.doi.org/10.1016/0092-8674(78)90096-X DOI 10.1016/S0022-2836(75)80185-9 http://dx.doi.org/10.1016/S0022-2836(75)80185-9 DOI 10.1016/S0092-8674(03)00427-6 http://dx.doi.org/10.1016/S0092-8674(03)00427-6 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb841 http://dx.doi.org/10.1038/nsb841 DOI 10.1093/nar/13.12.4521 http://dx.doi.org/10.1093/nar/13.12.4521 DOI 10.1111/j.1432-1033.1985.tb09048.x http://dx.doi.org/10.1111/j.1432-1033.1985.tb09048.x DOI 10.1111/j.1574-6968.1998.tb13343.x http://dx.doi.org/10.1111/j.1574-6968.1998.tb13343.x DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DisProt DP00242 http://www.disprot.org/protein.php?id=DP00242 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL V00357 http://www.ebi.ac.uk/ena/data/view/V00357 EMBL X01563 http://www.ebi.ac.uk/ena/data/view/X01563 EMBL X02613 http://www.ebi.ac.uk/ena/data/view/X02613 EchoBASE EB0909 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0909 EcoGene EG10916 http://www.ecogene.org/geneInfo.php?eg_id=EG10916 EnsemblBacteria AAC76336 http://www.ensemblgenomes.org/id/AAC76336 EnsemblBacteria AAC76336 http://www.ensemblgenomes.org/id/AAC76336 EnsemblBacteria BAE77980 http://www.ensemblgenomes.org/id/BAE77980 EnsemblBacteria BAE77980 http://www.ensemblgenomes.org/id/BAE77980 EnsemblBacteria BAE77980 http://www.ensemblgenomes.org/id/BAE77980 EnsemblBacteria b3311 http://www.ensemblgenomes.org/id/b3311 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0022627 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022627 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GO_function GO:0070181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070181 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 5552384 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5552384 GeneID 947808 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947808 HAMAP MF_01345_B http://hamap.expasy.org/unirule/MF_01345_B HOGENOM HOG000231339 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231339&db=HOGENOM6 InParanoid P0AG63 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AG63 IntAct P0AG63 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AG63* InterPro IPR000266 http://www.ebi.ac.uk/interpro/entry/IPR000266 InterPro IPR012340 http://www.ebi.ac.uk/interpro/entry/IPR012340 InterPro IPR019979 http://www.ebi.ac.uk/interpro/entry/IPR019979 InterPro IPR019984 http://www.ebi.ac.uk/interpro/entry/IPR019984 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW3273 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3273 KEGG_Gene eco:b3311 http://www.genome.jp/dbget-bin/www_bget?eco:b3311 KEGG_Orthology KO:K02961 http://www.genome.jp/dbget-bin/www_bget?KO:K02961 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 OMA LKAHDEQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LKAHDEQ PANTHER PTHR10744 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10744 PDB 1EG0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1EG0 PDB 1M5G http://www.ebi.ac.uk/pdbe-srv/view/entry/1M5G PDB 2YKR http://www.ebi.ac.uk/pdbe-srv/view/entry/2YKR PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 4A2I http://www.ebi.ac.uk/pdbe-srv/view/entry/4A2I PDB 4ADV http://www.ebi.ac.uk/pdbe-srv/view/entry/4ADV PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4V47 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V47 PDB 4V48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V48 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 1EG0 http://www.ebi.ac.uk/pdbsum/1EG0 PDBsum 1M5G http://www.ebi.ac.uk/pdbsum/1M5G PDBsum 2YKR http://www.ebi.ac.uk/pdbsum/2YKR PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 4A2I http://www.ebi.ac.uk/pdbsum/4A2I PDBsum 4ADV http://www.ebi.ac.uk/pdbsum/4ADV PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4V47 http://www.ebi.ac.uk/pdbsum/4V47 PDBsum 4V48 http://www.ebi.ac.uk/pdbsum/4V48 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PRINTS PR00973 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00973 PROSITE PS00056 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00056 PSORT swissprot:RS17_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RS17_ECOLI PSORT-B swissprot:RS17_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RS17_ECOLI PSORT2 swissprot:RS17_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RS17_ECOLI Pfam PF00366 http://pfam.xfam.org/family/PF00366 Phobius swissprot:RS17_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RS17_ECOLI PhylomeDB P0AG63 http://phylomedb.org/?seqid=P0AG63 ProteinModelPortal P0AG63 http://www.proteinmodelportal.org/query/uniprot/P0AG63 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 108517 http://www.ncbi.nlm.nih.gov/pubmed/108517 PubMed 12244297 http://www.ncbi.nlm.nih.gov/pubmed/12244297 PubMed 12809609 http://www.ncbi.nlm.nih.gov/pubmed/12809609 PubMed 151587 http://www.ncbi.nlm.nih.gov/pubmed/151587 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 344065 http://www.ncbi.nlm.nih.gov/pubmed/344065 PubMed 3892488 http://www.ncbi.nlm.nih.gov/pubmed/3892488 PubMed 3926498 http://www.ncbi.nlm.nih.gov/pubmed/3926498 PubMed 4598121 http://www.ncbi.nlm.nih.gov/pubmed/4598121 PubMed 7556101 http://www.ncbi.nlm.nih.gov/pubmed/7556101 PubMed 765484 http://www.ncbi.nlm.nih.gov/pubmed/765484 PubMed 781296 http://www.ncbi.nlm.nih.gov/pubmed/781296 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9868784 http://www.ncbi.nlm.nih.gov/pubmed/9868784 RefSeq NP_417770 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417770 RefSeq WP_000130100 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000130100 SMR P0AG63 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AG63 STRING 511145.b3311 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3311&targetmode=cogs STRING COG0186 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0186&targetmode=cogs SUPFAM SSF50249 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50249 TIGRFAMs TIGR03635 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03635 UniProtKB RS17_ECOLI http://www.uniprot.org/uniprot/RS17_ECOLI UniProtKB-AC P0AG63 http://www.uniprot.org/uniprot/P0AG63 charge swissprot:RS17_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RS17_ECOLI eggNOG COG0186 http://eggnogapi.embl.de/nog_data/html/tree/COG0186 epestfind swissprot:RS17_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RS17_ECOLI garnier swissprot:RS17_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RS17_ECOLI helixturnhelix swissprot:RS17_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RS17_ECOLI hmoment swissprot:RS17_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RS17_ECOLI iep swissprot:RS17_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RS17_ECOLI inforesidue swissprot:RS17_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RS17_ECOLI octanol swissprot:RS17_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RS17_ECOLI pepcoil swissprot:RS17_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RS17_ECOLI pepdigest swissprot:RS17_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RS17_ECOLI pepinfo swissprot:RS17_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RS17_ECOLI pepnet swissprot:RS17_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RS17_ECOLI pepstats swissprot:RS17_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RS17_ECOLI pepwheel swissprot:RS17_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RS17_ECOLI pepwindow swissprot:RS17_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RS17_ECOLI sigcleave swissprot:RS17_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RS17_ECOLI ## Database ID URL or Descriptions # AltName PBPC_ECOLI Peptidoglycan TGase # AltName PBPC_ECOLI Peptidoglycan TGase # BioGrid 4260591 250 # CAZy GT51 Glycosyltransferase Family 51 # DrugBank DB01327 Cefazolin # ENZYME REGULATION PBPC_ECOLI Transglycosylase activity can be inhibited by moenomycin. # EcoGene EG14210 pbpC # FUNCTION PBPC_ECOLI Cell wall formation. The enzyme has a penicillin- insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a transpeptidase C-terminal domain which may not be functional. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0008144 drug binding; IDA:EcoCyc. # GO_function GO:0008658 penicillin binding; IEA:InterPro. # GO_function GO:0008955 peptidoglycan glycosyltransferase activity; IDA:EcoCyc. # GO_process GO:0008360 regulation of cell shape; IEA:UniProtKB-KW. # GO_process GO:0009252 peptidoglycan biosynthetic process; IMP:EcoCyc. # GO_process GO:0051781 positive regulation of cell division; IDA:EcoliWiki. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 3.40.710.10 -; 1. # IntAct P76577 9 # InterPro IPR001264 Glyco_trans_51 # InterPro IPR001460 PCN-bd_Tpept # InterPro IPR009647 PBP_C # InterPro IPR011815 PBP_1c # InterPro IPR012338 Beta-lactam/transpept-like # InterPro IPR023346 Lysozyme-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01003 Glycosyltransferases # KEGG_Pathway ko00550 Peptidoglycan biosynthesis # MISCELLANEOUS PBPC_ECOLI Due to the fact that PBP-1c can neither substitute for PBP-1a or PBP-1b, nor rescue a PBP-1a/PBP-1b double mutant, it is possible that PBP-1c has its own distinct function. Moreover it does not bind to most of the beta-lactams known to bind to other binding proteins, suggesting that the penicillin-binding domain must be different from those present in PBP-1a and PBP-1b. It may function as a transglycosylase only. # Organism PBPC_ECOLI Escherichia coli (strain K12) # PATHWAY PBPC_ECOLI Cell wall biogenesis; peptidoglycan biosynthesis. # PATRIC 32120431 VBIEscCol129921_2618 # PIR F65028 F65028 # Pfam PF00905 Transpeptidase # Pfam PF00912 Transgly # Pfam PF06832 BiPBP_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PBPC_ECOLI Penicillin-binding protein 1C # RecName PBPC_ECOLI Penicillin-insensitive transglycosylase # RecName PBPC_ECOLI Transpeptidase-like module # RefSeq NP_417014 NC_000913.3 # RefSeq WP_001137675 NZ_LN832404.1 # SIMILARITY In the C-terminal section; belongs to the transpeptidase family. {ECO 0000305}. # SIMILARITY In the N-terminal section; belongs to the glycosyltransferase 51 family. {ECO 0000305}. # SUBCELLULAR LOCATION PBPC_ECOLI Cell inner membrane {ECO 0000250}; Single- pass type II membrane protein {ECO 0000250}. # SUPFAM SSF53955 SSF53955 # SUPFAM SSF56601 SSF56601 # TIGRFAMs TIGR02073 PBP_1c # eggNOG COG4953 LUCA # eggNOG ENOG4108JQB Bacteria BLAST swissprot:PBPC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PBPC_ECOLI BioCyc ECOL316407:JW2503-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2503-MONOMER BioCyc EcoCyc:G7322-MONOMER http://biocyc.org/getid?id=EcoCyc:G7322-MONOMER BioCyc MetaCyc:G7322-MONOMER http://biocyc.org/getid?id=MetaCyc:G7322-MONOMER COG CAZy: http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=CAZy: COG COG0744 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0744 COG GT51 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=GT51 DIP DIP-10442N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10442N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.274.45.32031 http://dx.doi.org/10.1074/jbc.274.45.32031 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB01327 http://www.drugbank.ca/drugs/DB01327 EC_number EC:2.4.2.- http://www.genome.jp/dbget-bin/www_bget?EC:2.4.2.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U88571 http://www.ebi.ac.uk/ena/data/view/U88571 ENZYME 2.4.2.- http://enzyme.expasy.org/EC/2.4.2.- EchoBASE EB3962 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3962 EcoGene EG14210 http://www.ecogene.org/geneInfo.php?eg_id=EG14210 EnsemblBacteria AAC75572 http://www.ensemblgenomes.org/id/AAC75572 EnsemblBacteria AAC75572 http://www.ensemblgenomes.org/id/AAC75572 EnsemblBacteria BAA16410 http://www.ensemblgenomes.org/id/BAA16410 EnsemblBacteria BAA16410 http://www.ensemblgenomes.org/id/BAA16410 EnsemblBacteria BAA16410 http://www.ensemblgenomes.org/id/BAA16410 EnsemblBacteria b2519 http://www.ensemblgenomes.org/id/b2519 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008144 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008144 GO_function GO:0008658 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008658 GO_function GO:0008955 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008955 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0009252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009252 GO_process GO:0051781 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051781 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 3.40.710.10 http://www.cathdb.info/version/latest/superfamily/3.40.710.10 GeneID 947152 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947152 HOGENOM HOG000041141 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000041141&db=HOGENOM6 InParanoid P76577 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76577 IntAct P76577 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76577* IntEnz 2.4.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.2 InterPro IPR001264 http://www.ebi.ac.uk/interpro/entry/IPR001264 InterPro IPR001460 http://www.ebi.ac.uk/interpro/entry/IPR001460 InterPro IPR009647 http://www.ebi.ac.uk/interpro/entry/IPR009647 InterPro IPR011815 http://www.ebi.ac.uk/interpro/entry/IPR011815 InterPro IPR012338 http://www.ebi.ac.uk/interpro/entry/IPR012338 InterPro IPR023346 http://www.ebi.ac.uk/interpro/entry/IPR023346 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01003 http://www.genome.jp/dbget-bin/www_bget?ko01003 KEGG_Gene ecj:JW2503 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2503 KEGG_Gene eco:b2519 http://www.genome.jp/dbget-bin/www_bget?eco:b2519 KEGG_Orthology KO:K05367 http://www.genome.jp/dbget-bin/www_bget?KO:K05367 KEGG_Pathway ko00550 http://www.genome.jp/kegg-bin/show_pathway?ko00550 MINT MINT-1308552 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1308552 OMA APENFDM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=APENFDM PSORT swissprot:PBPC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PBPC_ECOLI PSORT-B swissprot:PBPC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PBPC_ECOLI PSORT2 swissprot:PBPC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PBPC_ECOLI Pfam PF00905 http://pfam.xfam.org/family/PF00905 Pfam PF00912 http://pfam.xfam.org/family/PF00912 Pfam PF06832 http://pfam.xfam.org/family/PF06832 Phobius swissprot:PBPC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PBPC_ECOLI PhylomeDB P76577 http://phylomedb.org/?seqid=P76577 ProteinModelPortal P76577 http://www.proteinmodelportal.org/query/uniprot/P76577 PubMed 10542235 http://www.ncbi.nlm.nih.gov/pubmed/10542235 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9841666 http://www.ncbi.nlm.nih.gov/pubmed/9841666 RefSeq NP_417014 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417014 RefSeq WP_001137675 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001137675 SMR P76577 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76577 STRING 511145.b2519 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2519&targetmode=cogs STRING CAZy: http://string-db.org/newstring_cgi/show_network_section.pl?identifier=CAZy:&targetmode=cogs STRING COG0744 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0744&targetmode=cogs STRING GT51 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=GT51&targetmode=cogs SUPFAM SSF53955 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53955 SUPFAM SSF56601 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56601 TIGRFAMs TIGR02073 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02073 UniProtKB PBPC_ECOLI http://www.uniprot.org/uniprot/PBPC_ECOLI UniProtKB-AC P76577 http://www.uniprot.org/uniprot/P76577 charge swissprot:PBPC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PBPC_ECOLI eggNOG COG4953 http://eggnogapi.embl.de/nog_data/html/tree/COG4953 eggNOG ENOG4108JQB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108JQB epestfind swissprot:PBPC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PBPC_ECOLI garnier swissprot:PBPC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PBPC_ECOLI helixturnhelix swissprot:PBPC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PBPC_ECOLI hmoment swissprot:PBPC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PBPC_ECOLI iep swissprot:PBPC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PBPC_ECOLI inforesidue swissprot:PBPC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PBPC_ECOLI octanol swissprot:PBPC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PBPC_ECOLI pepcoil swissprot:PBPC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PBPC_ECOLI pepdigest swissprot:PBPC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PBPC_ECOLI pepinfo swissprot:PBPC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PBPC_ECOLI pepnet swissprot:PBPC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PBPC_ECOLI pepstats swissprot:PBPC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PBPC_ECOLI pepwheel swissprot:PBPC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PBPC_ECOLI pepwindow swissprot:PBPC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PBPC_ECOLI sigcleave swissprot:PBPC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PBPC_ECOLI ## Database ID URL or Descriptions # BioGrid 4260478 11 # EcoGene EG12049 yejM # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0008484 sulfuric ester hydrolase activity; IEA:InterPro. # GO_process GO:0008152 metabolic process; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0008150 biological_process # Gene3D 3.40.720.10 -; 1. # InterPro IPR000917 Sulfatase_N # InterPro IPR012159 YejM # InterPro IPR017849 Alkaline_Pase-like_a/b/a # InterPro IPR017850 Alkaline_phosphatase_core # InterPro IPR024588 YejM_N # Organism YEJM_ECOLI Escherichia coli (strain K12) # PATRIC 32119733 VBIEscCol129921_2277 # PDB 5I5H X-ray; 1.65 A; A=1-586 # PIR C64988 C64988 # PIRSF PIRSF004950 Mmb_sulf_HI0842 # Pfam PF00884 Sulfatase # Pfam PF11893 DUF3413 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEJM_ECOLI Inner membrane protein YejM # RefSeq NP_416693 NC_000913.3 # RefSeq WP_000256203 NZ_LN832404.1 # SIMILARITY To H.influenzae HI_0842. {ECO 0000305}. # SUBCELLULAR LOCATION YEJM_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF53649 SSF53649 # TCDB 2.A.127.1 enterobacterial cardiolipin transporter (clt) family # eggNOG COG3083 LUCA # eggNOG ENOG4105E68 Bacteria BLAST swissprot:YEJM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEJM_ECOLI BioCyc ECOL316407:JW2176-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2176-MONOMER BioCyc EcoCyc:EG12049-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12049-MONOMER COG COG3083 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3083 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00008 http://www.ebi.ac.uk/ena/data/view/U00008 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1981 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1981 EcoGene EG12049 http://www.ecogene.org/geneInfo.php?eg_id=EG12049 EnsemblBacteria AAC75249 http://www.ensemblgenomes.org/id/AAC75249 EnsemblBacteria AAC75249 http://www.ensemblgenomes.org/id/AAC75249 EnsemblBacteria BAE76653 http://www.ensemblgenomes.org/id/BAE76653 EnsemblBacteria BAE76653 http://www.ensemblgenomes.org/id/BAE76653 EnsemblBacteria BAE76653 http://www.ensemblgenomes.org/id/BAE76653 EnsemblBacteria b2188 http://www.ensemblgenomes.org/id/b2188 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008484 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008484 GO_process GO:0008152 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008152 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.720.10 http://www.cathdb.info/version/latest/superfamily/3.40.720.10 GeneID 946685 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946685 HOGENOM HOG000275802 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275802&db=HOGENOM6 InParanoid P0AD27 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AD27 InterPro IPR000917 http://www.ebi.ac.uk/interpro/entry/IPR000917 InterPro IPR012159 http://www.ebi.ac.uk/interpro/entry/IPR012159 InterPro IPR017849 http://www.ebi.ac.uk/interpro/entry/IPR017849 InterPro IPR017850 http://www.ebi.ac.uk/interpro/entry/IPR017850 InterPro IPR024588 http://www.ebi.ac.uk/interpro/entry/IPR024588 KEGG_Gene ecj:JW2176 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2176 KEGG_Gene eco:b2188 http://www.genome.jp/dbget-bin/www_bget?eco:b2188 KEGG_Orthology KO:K07014 http://www.genome.jp/dbget-bin/www_bget?KO:K07014 OMA YAFIIDW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YAFIIDW PDB 5I5H http://www.ebi.ac.uk/pdbe-srv/view/entry/5I5H PDBsum 5I5H http://www.ebi.ac.uk/pdbsum/5I5H PSORT swissprot:YEJM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEJM_ECOLI PSORT-B swissprot:YEJM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEJM_ECOLI PSORT2 swissprot:YEJM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEJM_ECOLI Pfam PF00884 http://pfam.xfam.org/family/PF00884 Pfam PF11893 http://pfam.xfam.org/family/PF11893 Phobius swissprot:YEJM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEJM_ECOLI ProteinModelPortal P0AD27 http://www.proteinmodelportal.org/query/uniprot/P0AD27 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416693 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416693 RefSeq WP_000256203 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000256203 SMR P0AD27 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AD27 STRING 511145.b2188 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2188&targetmode=cogs STRING COG3083 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3083&targetmode=cogs SUPFAM SSF53649 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53649 TCDB 2.A.127.1 http://www.tcdb.org/search/result.php?tc=2.A.127.1 UniProtKB YEJM_ECOLI http://www.uniprot.org/uniprot/YEJM_ECOLI UniProtKB-AC P0AD27 http://www.uniprot.org/uniprot/P0AD27 charge swissprot:YEJM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEJM_ECOLI eggNOG COG3083 http://eggnogapi.embl.de/nog_data/html/tree/COG3083 eggNOG ENOG4105E68 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E68 epestfind swissprot:YEJM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEJM_ECOLI garnier swissprot:YEJM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEJM_ECOLI helixturnhelix swissprot:YEJM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEJM_ECOLI hmoment swissprot:YEJM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEJM_ECOLI iep swissprot:YEJM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEJM_ECOLI inforesidue swissprot:YEJM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEJM_ECOLI octanol swissprot:YEJM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEJM_ECOLI pepcoil swissprot:YEJM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEJM_ECOLI pepdigest swissprot:YEJM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEJM_ECOLI pepinfo swissprot:YEJM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEJM_ECOLI pepnet swissprot:YEJM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEJM_ECOLI pepstats swissprot:YEJM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEJM_ECOLI pepwheel swissprot:YEJM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEJM_ECOLI pepwindow swissprot:YEJM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEJM_ECOLI sigcleave swissprot:YEJM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEJM_ECOLI ## Database ID URL or Descriptions # BioGrid 4260150 9 # EcoGene EG11042 tyrR # FUNCTION TYRR_ECOLI Involved in transcriptional regulation of aromatic amino acid biosynthesis and transport. Modulates the expression of at least 8 unlinked operons. Seven of these operons are regulated in response to changes in the concentration of the three aromatic amino acids (phenylalanine, tyrosine and tryptophan). These amino acids are suggested to act as co-effectors which bind to the TyrR protein to form an active regulatory protein. In most cases TyrR causes negative regulation, but positive effects on the tyrP gene have been observed at high phenylalanine concentrations. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IDA:EcoCyc. # GO_function GO:0016597 amino acid binding; IEA:InterPro. # GO_process GO:0000160 phosphorelay signal transduction system; IEA:UniProtKB-KW. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0019439 aromatic compound catabolic process; IEA:UniProtKB-KW. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0007165 signal transduction # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.60 -; 1. # Gene3D 3.40.50.300 -; 1. # IntAct P07604 4 # InterPro IPR000014 PAS # InterPro IPR002078 Sigma_54_int # InterPro IPR002912 ACT_dom # InterPro IPR003593 AAA+_ATPase # InterPro IPR009057 Homeodomain-like # InterPro IPR025662 Sigma_54_int_dom_ATP-bd_1 # InterPro IPR025943 Sigma_54_int_dom_ATP-bd_2 # InterPro IPR025944 Sigma_54_int_dom_CS # InterPro IPR027417 P-loop_NTPase # InterPro IPR030828 HTH_TypR # KEGG_Brite ko03000 Transcription factors # MISCELLANEOUS TYRR_ECOLI The tyrR gene is autogenously regulated by a mechanism that gives similar rates of expression of tyrR irrespective of concentration of the aromatic amino acids. # Organism TYRR_ECOLI Escherichia coli (strain K12) # PATRIC 32117920 VBIEscCol129921_1380 # PDB 2JHE X-ray; 2.30 A; A/B/C/D=1-190 # PIR A47086 RGECAY # PROSITE PS00675 SIGMA54_INTERACT_1 # PROSITE PS00676 SIGMA54_INTERACT_2 # PROSITE PS00688 SIGMA54_INTERACT_3 # PROSITE PS50045 SIGMA54_INTERACT_4 # PROSITE PS50112 PAS # PROSITE PS51671 ACT # Pfam PF00158 Sigma54_activat # Pfam PF13188 PAS_8 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TYRR_ECOLI Transcriptional regulatory protein TyrR # RefSeq NP_415839 NC_000913.3 # RefSeq WP_001300658 NZ_LN832404.1 # SIMILARITY Contains 1 ACT domain. {ECO:0000255|PROSITE- ProRule PRU01007}. # SIMILARITY Contains 1 PAS (PER-ARNT-SIM) domain. {ECO:0000255|PROSITE-ProRule PRU00140}. # SIMILARITY Contains 1 sigma-54 factor interaction domain. {ECO:0000255|PROSITE-ProRule PRU00193}. # SMART SM00091 PAS # SMART SM00382 AAA # SUBUNIT TYRR_ECOLI Homodimer. In presence of tyrosine (to the lesser extent, phenylalanine or tryptophan) and excess of ATP it undergoes a ligand-induced hexamerization. It is suggested that the hexameric form of TyrR is the active repressing species, interacting with two or three tyrR boxes in the targeted regulatory DNA. {ECO 0000269|PubMed 8176727, ECO 0000269|PubMed 8947567}. # SUPFAM SSF46689 SSF46689 # SUPFAM SSF52540 SSF52540 # SUPFAM SSF55785 SSF55785 # TIGRFAMs TIGR04381 HTH_TypR # eggNOG COG3283 LUCA # eggNOG ENOG4108JU8 Bacteria BLAST swissprot:TYRR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TYRR_ECOLI BioCyc ECOL316407:JW1316-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1316-MONOMER BioCyc EcoCyc:PD00413 http://biocyc.org/getid?id=EcoCyc:PD00413 COG COG3283 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3283 DIP DIP-11062N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11062N DOI 10.1006/jmbi.1994.1294 http://dx.doi.org/10.1006/jmbi.1994.1294 DOI 10.1006/jmbi.1996.0607 http://dx.doi.org/10.1006/jmbi.1996.0607 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1111/j.1365-2958.1991.tb01904.x http://dx.doi.org/10.1111/j.1365-2958.1991.tb01904.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M12114 http://www.ebi.ac.uk/ena/data/view/M12114 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1035 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1035 EcoGene EG11042 http://www.ecogene.org/geneInfo.php?eg_id=EG11042 EnsemblBacteria AAC74405 http://www.ensemblgenomes.org/id/AAC74405 EnsemblBacteria AAC74405 http://www.ensemblgenomes.org/id/AAC74405 EnsemblBacteria BAA14905 http://www.ensemblgenomes.org/id/BAA14905 EnsemblBacteria BAA14905 http://www.ensemblgenomes.org/id/BAA14905 EnsemblBacteria BAA14905 http://www.ensemblgenomes.org/id/BAA14905 EnsemblBacteria b1323 http://www.ensemblgenomes.org/id/b1323 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016597 GO_process GO:0000160 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000160 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0019439 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019439 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0007165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007165 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.60 http://www.cathdb.info/version/latest/superfamily/1.10.10.60 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945879 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945879 HOGENOM HOG000058487 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000058487&db=HOGENOM6 InParanoid P07604 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P07604 IntAct P07604 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P07604* InterPro IPR000014 http://www.ebi.ac.uk/interpro/entry/IPR000014 InterPro IPR002078 http://www.ebi.ac.uk/interpro/entry/IPR002078 InterPro IPR002912 http://www.ebi.ac.uk/interpro/entry/IPR002912 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR009057 http://www.ebi.ac.uk/interpro/entry/IPR009057 InterPro IPR025662 http://www.ebi.ac.uk/interpro/entry/IPR025662 InterPro IPR025943 http://www.ebi.ac.uk/interpro/entry/IPR025943 InterPro IPR025944 http://www.ebi.ac.uk/interpro/entry/IPR025944 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 InterPro IPR030828 http://www.ebi.ac.uk/interpro/entry/IPR030828 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW1316 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1316 KEGG_Gene eco:b1323 http://www.genome.jp/dbget-bin/www_bget?eco:b1323 KEGG_Orthology KO:K03721 http://www.genome.jp/dbget-bin/www_bget?KO:K03721 MINT MINT-1240380 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1240380 OMA LFAHACH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LFAHACH PDB 2JHE http://www.ebi.ac.uk/pdbe-srv/view/entry/2JHE PDBsum 2JHE http://www.ebi.ac.uk/pdbsum/2JHE PROSITE PS00675 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00675 PROSITE PS00676 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00676 PROSITE PS00688 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00688 PROSITE PS50045 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50045 PROSITE PS50112 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50112 PROSITE PS51671 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51671 PSORT swissprot:TYRR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TYRR_ECOLI PSORT-B swissprot:TYRR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TYRR_ECOLI PSORT2 swissprot:TYRR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TYRR_ECOLI Pfam PF00158 http://pfam.xfam.org/family/PF00158 Pfam PF13188 http://pfam.xfam.org/family/PF13188 Phobius swissprot:TYRR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TYRR_ECOLI PhylomeDB P07604 http://phylomedb.org/?seqid=P07604 ProteinModelPortal P07604 http://www.proteinmodelportal.org/query/uniprot/P07604 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1943694 http://www.ncbi.nlm.nih.gov/pubmed/1943694 PubMed 3001057 http://www.ncbi.nlm.nih.gov/pubmed/3001057 PubMed 8106498 http://www.ncbi.nlm.nih.gov/pubmed/8106498 PubMed 8176727 http://www.ncbi.nlm.nih.gov/pubmed/8176727 PubMed 8444880 http://www.ncbi.nlm.nih.gov/pubmed/8444880 PubMed 8449883 http://www.ncbi.nlm.nih.gov/pubmed/8449883 PubMed 8947567 http://www.ncbi.nlm.nih.gov/pubmed/8947567 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415839 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415839 RefSeq WP_001300658 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300658 SMART SM00091 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00091 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P07604 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P07604 STRING 511145.b1323 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1323&targetmode=cogs STRING COG3283 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3283&targetmode=cogs SUPFAM SSF46689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46689 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SUPFAM SSF55785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55785 TIGRFAMs TIGR04381 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR04381 UniProtKB TYRR_ECOLI http://www.uniprot.org/uniprot/TYRR_ECOLI UniProtKB-AC P07604 http://www.uniprot.org/uniprot/P07604 charge swissprot:TYRR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TYRR_ECOLI eggNOG COG3283 http://eggnogapi.embl.de/nog_data/html/tree/COG3283 eggNOG ENOG4108JU8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108JU8 epestfind swissprot:TYRR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TYRR_ECOLI garnier swissprot:TYRR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TYRR_ECOLI helixturnhelix swissprot:TYRR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TYRR_ECOLI hmoment swissprot:TYRR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TYRR_ECOLI iep swissprot:TYRR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TYRR_ECOLI inforesidue swissprot:TYRR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TYRR_ECOLI octanol swissprot:TYRR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TYRR_ECOLI pepcoil swissprot:TYRR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TYRR_ECOLI pepdigest swissprot:TYRR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TYRR_ECOLI pepinfo swissprot:TYRR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TYRR_ECOLI pepnet swissprot:TYRR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TYRR_ECOLI pepstats swissprot:TYRR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TYRR_ECOLI pepwheel swissprot:TYRR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TYRR_ECOLI pepwindow swissprot:TYRR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TYRR_ECOLI sigcleave swissprot:TYRR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TYRR_ECOLI ## Database ID URL or Descriptions # AltName FUCO_ECOLI Propanediol oxidoreductase # BioGrid 4259223 91 # CATALYTIC ACTIVITY FUCO_ECOLI (R)-propane-1,2-diol + NAD(+) = (R)- lactaldehyde + NADH. # CATALYTIC ACTIVITY FUCO_ECOLI (S)-propane-1,2-diol + NAD(+) = (S)- lactaldehyde + NADH. # COFACTOR FUCO_ECOLI Name=Fe cation; Xref=ChEBI CHEBI 24875; Evidence={ECO 0000269|PubMed 15995211}; # ENZYME REGULATION Inhibited by Zn(2+). {ECO:0000269|PubMed 15995211}. # EcoGene EG10351 fucO # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008198 ferrous iron binding; IDA:EcoCyc. # GO_function GO:0008912 lactaldehyde reductase activity; IDA:EcoCyc. # GO_process GO:0019301 rhamnose catabolic process; IEP:EcoCyc. # GO_process GO:0042355 L-fucose catabolic process; IMP:EcoCyc. # GO_process GO:0042846 glycol catabolic process; IDA:EcoCyc. # GO_process GO:0051143 propanediol metabolic process; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # IntAct P0A9S1 5 # InterPro IPR001670 ADH_Fe # InterPro IPR013460 Lactal_redase # InterPro IPR018211 ADH_Fe_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00620 Pyruvate metabolism # KEGG_Pathway ko00630 Glyoxylate and dicarboxylate metabolism # Organism FUCO_ECOLI Escherichia coli (strain K12) # PATHWAY FUCO_ECOLI Carbohydrate degradation; L-fucose degradation. # PATRIC 32121014 VBIEscCol129921_2899 # PDB 1RRM X-ray; 1.60 A; A/B=1-382 # PDB 2BI4 X-ray; 2.85 A; A/B=1-382 # PDB 2BL4 X-ray; 2.85 A; A/B=1-382 # PDB 5BR4 X-ray; 0.91 A; A/B=1-382 # PIR A32883 RDECLA # PROSITE PS00060 ADH_IRON_2 # PROSITE PS00913 ADH_IRON_1 # Pfam PF00465 Fe-ADH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FUCO_ECOLI Lactaldehyde reductase # RefSeq NP_417279 NC_000913.3 # RefSeq WP_000013588 NZ_LN832404.1 # SEQUENCE CAUTION FUCO_ECOLI Sequence=AAA23824.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=AAA23825.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=AAB40449.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=BAE76871.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=CAA33124.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the iron-containing alcohol dehydrogenase family. {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 15995211}. # TIGRFAMs TIGR02638 lactal_redase # eggNOG COG1454 LUCA # eggNOG ENOG4105C0A Bacteria BLAST swissprot:FUCO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FUCO_ECOLI BioCyc ECOL316407:JW2770-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2770-MONOMER BioCyc EcoCyc:LACTALDREDUCT-MONOMER http://biocyc.org/getid?id=EcoCyc:LACTALDREDUCT-MONOMER BioCyc MetaCyc:LACTALDREDUCT-MONOMER http://biocyc.org/getid?id=MetaCyc:LACTALDREDUCT-MONOMER COG COG1454 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1454 DIP DIP-48076N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48076N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/17.12.4883 http://dx.doi.org/10.1093/nar/17.12.4883 DOI 10.1111/j.1432-1033.1993.tb17718.x http://dx.doi.org/10.1111/j.1432-1033.1993.tb17718.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.187.14.4957-4966.2005 http://dx.doi.org/10.1128/JB.187.14.4957-4966.2005 EC_number EC:1.1.1.77 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.77 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L07763 http://www.ebi.ac.uk/ena/data/view/L07763 EMBL M27177 http://www.ebi.ac.uk/ena/data/view/M27177 EMBL M31059 http://www.ebi.ac.uk/ena/data/view/M31059 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 EMBL X15025 http://www.ebi.ac.uk/ena/data/view/X15025 ENZYME 1.1.1.77 http://enzyme.expasy.org/EC/1.1.1.77 EchoBASE EB0347 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0347 EcoGene EG10351 http://www.ecogene.org/geneInfo.php?eg_id=EG10351 EnsemblBacteria AAC75841 http://www.ensemblgenomes.org/id/AAC75841 EnsemblBacteria AAC75841 http://www.ensemblgenomes.org/id/AAC75841 EnsemblBacteria BAE76871 http://www.ensemblgenomes.org/id/BAE76871 EnsemblBacteria BAE76871 http://www.ensemblgenomes.org/id/BAE76871 EnsemblBacteria BAE76871 http://www.ensemblgenomes.org/id/BAE76871 EnsemblBacteria b2799 http://www.ensemblgenomes.org/id/b2799 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008198 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008198 GO_function GO:0008912 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008912 GO_process GO:0019301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019301 GO_process GO:0042355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042355 GO_process GO:0042846 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042846 GO_process GO:0051143 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051143 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 947273 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947273 HOGENOM HOG000243333 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000243333&db=HOGENOM6 InParanoid P0A9S1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9S1 IntAct P0A9S1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9S1* IntEnz 1.1.1.77 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.77 InterPro IPR001670 http://www.ebi.ac.uk/interpro/entry/IPR001670 InterPro IPR013460 http://www.ebi.ac.uk/interpro/entry/IPR013460 InterPro IPR018211 http://www.ebi.ac.uk/interpro/entry/IPR018211 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2770 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2770 KEGG_Gene eco:b2799 http://www.genome.jp/dbget-bin/www_bget?eco:b2799 KEGG_Orthology KO:K00048 http://www.genome.jp/dbget-bin/www_bget?KO:K00048 KEGG_Pathway ko00620 http://www.genome.jp/kegg-bin/show_pathway?ko00620 KEGG_Pathway ko00630 http://www.genome.jp/kegg-bin/show_pathway?ko00630 KEGG_Reaction rn:R01781 http://www.genome.jp/dbget-bin/www_bget?rn:R01781 KEGG_Reaction rn:R02257 http://www.genome.jp/dbget-bin/www_bget?rn:R02257 MINT MINT-1223334 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1223334 OMA DIVGLYQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DIVGLYQ PDB 1RRM http://www.ebi.ac.uk/pdbe-srv/view/entry/1RRM PDB 2BI4 http://www.ebi.ac.uk/pdbe-srv/view/entry/2BI4 PDB 2BL4 http://www.ebi.ac.uk/pdbe-srv/view/entry/2BL4 PDB 5BR4 http://www.ebi.ac.uk/pdbe-srv/view/entry/5BR4 PDBsum 1RRM http://www.ebi.ac.uk/pdbsum/1RRM PDBsum 2BI4 http://www.ebi.ac.uk/pdbsum/2BI4 PDBsum 2BL4 http://www.ebi.ac.uk/pdbsum/2BL4 PDBsum 5BR4 http://www.ebi.ac.uk/pdbsum/5BR4 PROSITE PS00060 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00060 PROSITE PS00913 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00913 PSORT swissprot:FUCO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FUCO_ECOLI PSORT-B swissprot:FUCO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FUCO_ECOLI PSORT2 swissprot:FUCO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FUCO_ECOLI Pfam PF00465 http://pfam.xfam.org/family/PF00465 Phobius swissprot:FUCO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FUCO_ECOLI ProteinModelPortal P0A9S1 http://www.proteinmodelportal.org/query/uniprot/P0A9S1 PubMed 15995211 http://www.ncbi.nlm.nih.gov/pubmed/15995211 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2553671 http://www.ncbi.nlm.nih.gov/pubmed/2553671 PubMed 2661535 http://www.ncbi.nlm.nih.gov/pubmed/2661535 PubMed 2664711 http://www.ncbi.nlm.nih.gov/pubmed/2664711 PubMed 8385012 http://www.ncbi.nlm.nih.gov/pubmed/8385012 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417279 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417279 RefSeq WP_000013588 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000013588 SMR P0A9S1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9S1 STRING 511145.b2799 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2799&targetmode=cogs STRING COG1454 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1454&targetmode=cogs TIGRFAMs TIGR02638 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02638 UniProtKB FUCO_ECOLI http://www.uniprot.org/uniprot/FUCO_ECOLI UniProtKB-AC P0A9S1 http://www.uniprot.org/uniprot/P0A9S1 charge swissprot:FUCO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FUCO_ECOLI eggNOG COG1454 http://eggnogapi.embl.de/nog_data/html/tree/COG1454 eggNOG ENOG4105C0A http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C0A epestfind swissprot:FUCO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FUCO_ECOLI garnier swissprot:FUCO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FUCO_ECOLI helixturnhelix swissprot:FUCO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FUCO_ECOLI hmoment swissprot:FUCO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FUCO_ECOLI iep swissprot:FUCO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FUCO_ECOLI inforesidue swissprot:FUCO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FUCO_ECOLI octanol swissprot:FUCO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FUCO_ECOLI pepcoil swissprot:FUCO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FUCO_ECOLI pepdigest swissprot:FUCO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FUCO_ECOLI pepinfo swissprot:FUCO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FUCO_ECOLI pepnet swissprot:FUCO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FUCO_ECOLI pepstats swissprot:FUCO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FUCO_ECOLI pepwheel swissprot:FUCO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FUCO_ECOLI pepwindow swissprot:FUCO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FUCO_ECOLI sigcleave swissprot:FUCO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FUCO_ECOLI ## Database ID URL or Descriptions # AltName EPMC_ECOLI EF-P post-translational modification enzyme C # BioGrid 4260792 4 # DISRUPTION PHENOTYPE EPMC_ECOLI EF-P proteins in the mutant strain displays a modification of +128 Da, whereas a modification of +144 Da is observed in wild-type strains. Cells lack CadA activity (lysine decarboxylase). {ECO 0000269|PubMed 22706199, ECO 0000269|PubMed 23239623}. # ENZYME REGULATION Hydroxylation activity is abolished by NADP and increased by NADPH. {ECO:0000269|PubMed 22706199}. # EcoGene EG14116 epmC # FUNCTION EPMC_ECOLI Is involved in the final hydroxylation step of the post- translational modification of translation elongation factor P (EF- P) on 'Lys-34'. Acts after beta-lysylation of 'Lys-34' by EpmA and EpmB. EpmC adds an oxygen atom to the C5 position of 'Lys-34' and does not modify the added beta-lysine. {ECO 0000269|PubMed 22706199}. # GO_function GO:0004497 monooxygenase activity; IDA:UniProtKB. # GO_function GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IDA:EcoCyc. # GO_process GO:0043687 post-translational protein modification; IDA:UniProtKB. # GO_process GO:1901260 peptidyl-lysine hydroxylation involved in bacterial-type EF-P lysine modification; IMP:EcoCyc. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006464 cellular protein modification process # IntAct P76938 5 # InterPro IPR007411 EpmC # Organism EPMC_ECOLI Escherichia coli (strain K12) # PATRIC 32120025 VBIEscCol129921_2422 # PIR D65005 D65005 # Pfam PF04315 EpmC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EPMC_ECOLI Elongation factor P hydroxylase # RefSeq NP_416829 NC_000913.3 # RefSeq WP_001089222 NZ_LN832404.1 # SIMILARITY Belongs to the EpmC family. {ECO 0000305}. # eggNOG COG3101 LUCA # eggNOG ENOG4108BPE Bacteria BLAST swissprot:EPMC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EPMC_ECOLI BioCyc ECOL316407:JW5381-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5381-MONOMER BioCyc EcoCyc:G7201-MONOMER http://biocyc.org/getid?id=EcoCyc:G7201-MONOMER BioCyc MetaCyc:G7201-MONOMER http://biocyc.org/getid?id=MetaCyc:G7201-MONOMER COG COG3101 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3101 DIP DIP-11984N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11984N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nchembio.1001 http://dx.doi.org/10.1038/nchembio.1001 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.1228985 http://dx.doi.org/10.1126/science.1228985 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.14.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.14.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.14.-.- http://enzyme.expasy.org/EC/1.14.-.- EchoBASE EB3869 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3869 EcoGene EG14116 http://www.ecogene.org/geneInfo.php?eg_id=EG14116 EnsemblBacteria AAC75386 http://www.ensemblgenomes.org/id/AAC75386 EnsemblBacteria AAC75386 http://www.ensemblgenomes.org/id/AAC75386 EnsemblBacteria BAA16182 http://www.ensemblgenomes.org/id/BAA16182 EnsemblBacteria BAA16182 http://www.ensemblgenomes.org/id/BAA16182 EnsemblBacteria BAA16182 http://www.ensemblgenomes.org/id/BAA16182 EnsemblBacteria b2326 http://www.ensemblgenomes.org/id/b2326 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004497 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004497 GO_function GO:0016709 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016709 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0043687 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043687 GO_process GO:1901260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901260 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GeneID 946807 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946807 HOGENOM HOG000122499 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122499&db=HOGENOM6 IntAct P76938 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76938* IntEnz 1.14 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.14 InterPro IPR007411 http://www.ebi.ac.uk/interpro/entry/IPR007411 KEGG_Gene ecj:JW5381 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5381 KEGG_Gene eco:b2326 http://www.genome.jp/dbget-bin/www_bget?eco:b2326 KEGG_Orthology KO:K09906 http://www.genome.jp/dbget-bin/www_bget?KO:K09906 OMA HAQVMQY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HAQVMQY PSORT swissprot:EPMC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EPMC_ECOLI PSORT-B swissprot:EPMC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EPMC_ECOLI PSORT2 swissprot:EPMC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EPMC_ECOLI Pfam PF04315 http://pfam.xfam.org/family/PF04315 Phobius swissprot:EPMC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EPMC_ECOLI ProteinModelPortal P76938 http://www.proteinmodelportal.org/query/uniprot/P76938 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22706199 http://www.ncbi.nlm.nih.gov/pubmed/22706199 PubMed 23239623 http://www.ncbi.nlm.nih.gov/pubmed/23239623 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416829 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416829 RefSeq WP_001089222 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001089222 SMR P76938 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76938 STRING 511145.b2326 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2326&targetmode=cogs STRING COG3101 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3101&targetmode=cogs UniProtKB EPMC_ECOLI http://www.uniprot.org/uniprot/EPMC_ECOLI UniProtKB-AC P76938 http://www.uniprot.org/uniprot/P76938 charge swissprot:EPMC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EPMC_ECOLI eggNOG COG3101 http://eggnogapi.embl.de/nog_data/html/tree/COG3101 eggNOG ENOG4108BPE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108BPE epestfind swissprot:EPMC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EPMC_ECOLI garnier swissprot:EPMC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EPMC_ECOLI helixturnhelix swissprot:EPMC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EPMC_ECOLI hmoment swissprot:EPMC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EPMC_ECOLI iep swissprot:EPMC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EPMC_ECOLI inforesidue swissprot:EPMC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EPMC_ECOLI octanol swissprot:EPMC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EPMC_ECOLI pepcoil swissprot:EPMC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EPMC_ECOLI pepdigest swissprot:EPMC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EPMC_ECOLI pepinfo swissprot:EPMC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EPMC_ECOLI pepnet swissprot:EPMC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EPMC_ECOLI pepstats swissprot:EPMC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EPMC_ECOLI pepwheel swissprot:EPMC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EPMC_ECOLI pepwindow swissprot:EPMC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EPMC_ECOLI sigcleave swissprot:EPMC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EPMC_ECOLI ## Database ID URL or Descriptions # BioGrid 4263209 14 # CDD cd01005 PBP2_CysP # EcoGene EG10195 cysP # FUNCTION CYSP_ECOLI Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. This protein specifically binds thiosulfate and is involved in its transmembrane transport. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0008271 secondary active sulfate transmembrane transporter activity; IEA:InterPro. # GO_function GO:0015419 ATPase-coupled sulfate transmembrane transporter activity; IEA:InterPro. # GO_function GO:0043168 anion binding; IMP:EcoCyc. # GO_process GO:0006790 sulfur compound metabolic process; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006790 sulfur compound metabolic process # IntAct P16700 4 # InterPro IPR000957 Sulphate/thiosulphate-bd_CS # InterPro IPR005669 Thiosulph/SO4-bd # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00185 Sulfate transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism CYSP_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30368 PTHR30368 # PATRIC 32120235 VBIEscCol129921_2520 # PIR A35403 JGECT # PROSITE PS00401 PROK_SULFATE_BIND_1 # PROSITE PS00757 PROK_SULFATE_BIND_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CYSP_ECOLI Thiosulfate-binding protein # RefSeq NP_416920 NC_000913.3 # RefSeq WP_000290230 NZ_LN832404.1 # SIMILARITY Belongs to the prokaryotic sulfate-binding protein family. {ECO 0000305}. # SUBCELLULAR LOCATION CYSP_ECOLI Periplasm. # SUBUNIT The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute- binding protein (CysP). {ECO 0000305}. # TCDB 3.A.1.6 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR00971 3a0106s03 # eggNOG COG4150 LUCA # eggNOG ENOG4108J2H Bacteria BLAST swissprot:CYSP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CYSP_ECOLI BioCyc ECOL316407:JW2418-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2418-MONOMER BioCyc EcoCyc:CYSP-MONOMER http://biocyc.org/getid?id=EcoCyc:CYSP-MONOMER BioCyc MetaCyc:CYSP-MONOMER http://biocyc.org/getid?id=MetaCyc:CYSP-MONOMER COG COG1613 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1613 DIP DIP-9384N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9384N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M32101 http://www.ebi.ac.uk/ena/data/view/M32101 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0192 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0192 EcoGene EG10195 http://www.ecogene.org/geneInfo.php?eg_id=EG10195 EnsemblBacteria AAC75478 http://www.ensemblgenomes.org/id/AAC75478 EnsemblBacteria AAC75478 http://www.ensemblgenomes.org/id/AAC75478 EnsemblBacteria BAA16299 http://www.ensemblgenomes.org/id/BAA16299 EnsemblBacteria BAA16299 http://www.ensemblgenomes.org/id/BAA16299 EnsemblBacteria BAA16299 http://www.ensemblgenomes.org/id/BAA16299 EnsemblBacteria b2425 http://www.ensemblgenomes.org/id/b2425 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0008271 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008271 GO_function GO:0015419 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015419 GO_function GO:0043168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043168 GO_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GeneID 946883 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946883 HOGENOM HOG000260057 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260057&db=HOGENOM6 InParanoid P16700 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P16700 IntAct P16700 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P16700* InterPro IPR000957 http://www.ebi.ac.uk/interpro/entry/IPR000957 InterPro IPR005669 http://www.ebi.ac.uk/interpro/entry/IPR005669 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2418 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2418 KEGG_Gene eco:b2425 http://www.genome.jp/dbget-bin/www_bget?eco:b2425 KEGG_Orthology KO:K02048 http://www.genome.jp/dbget-bin/www_bget?KO:K02048 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA VDQSHAG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VDQSHAG PANTHER PTHR30368 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30368 PROSITE PS00401 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00401 PROSITE PS00757 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00757 PSORT swissprot:CYSP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CYSP_ECOLI PSORT-B swissprot:CYSP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CYSP_ECOLI PSORT2 swissprot:CYSP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CYSP_ECOLI Phobius swissprot:CYSP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CYSP_ECOLI PhylomeDB P16700 http://phylomedb.org/?seqid=P16700 ProteinModelPortal P16700 http://www.proteinmodelportal.org/query/uniprot/P16700 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2188959 http://www.ncbi.nlm.nih.gov/pubmed/2188959 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_416920 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416920 RefSeq WP_000290230 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000290230 SMR P16700 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P16700 STRING 511145.b2425 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2425&targetmode=cogs STRING COG1613 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1613&targetmode=cogs SWISS-2DPAGE P16700 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P16700 TCDB 3.A.1.6 http://www.tcdb.org/search/result.php?tc=3.A.1.6 TIGRFAMs TIGR00971 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00971 UniProtKB CYSP_ECOLI http://www.uniprot.org/uniprot/CYSP_ECOLI UniProtKB-AC P16700 http://www.uniprot.org/uniprot/P16700 charge swissprot:CYSP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CYSP_ECOLI eggNOG COG4150 http://eggnogapi.embl.de/nog_data/html/tree/COG4150 eggNOG ENOG4108J2H http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108J2H epestfind swissprot:CYSP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CYSP_ECOLI garnier swissprot:CYSP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CYSP_ECOLI helixturnhelix swissprot:CYSP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CYSP_ECOLI hmoment swissprot:CYSP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CYSP_ECOLI iep swissprot:CYSP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CYSP_ECOLI inforesidue swissprot:CYSP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CYSP_ECOLI octanol swissprot:CYSP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CYSP_ECOLI pepcoil swissprot:CYSP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CYSP_ECOLI pepdigest swissprot:CYSP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CYSP_ECOLI pepinfo swissprot:CYSP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CYSP_ECOLI pepnet swissprot:CYSP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CYSP_ECOLI pepstats swissprot:CYSP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CYSP_ECOLI pepwheel swissprot:CYSP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CYSP_ECOLI pepwindow swissprot:CYSP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CYSP_ECOLI sigcleave swissprot:CYSP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CYSP_ECOLI ## Database ID URL or Descriptions # AltName EDD_ECOLI 6-phosphogluconate dehydratase # BioGrid 4261382 5 # CATALYTIC ACTIVITY EDD_ECOLI 6-phospho-D-gluconate = 2-dehydro-3-deoxy-6- phospho-D-gluconate + H(2)O. # EcoGene EG10257 edd # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0004456 phosphogluconate dehydratase activity; IMP:EcoliWiki. # GO_process GO:0009082 branched-chain amino acid biosynthetic process; IBA:GO_Central. # GO_process GO:0009255 Entner-Doudoroff pathway through 6-phosphogluconate; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # INDUCTION EDD_ECOLI By growth on gluconate. # IntAct P0ADF6 8 # InterPro IPR000581 DiOHA_6PGluconate_deHydtase # InterPro IPR004786 6-phosphgluc_deHydtase # InterPro IPR015928 Aconitase/3IPM_dehydase_swvl # InterPro IPR020558 DiOHA_6PGluconate_deHydtase_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00030 Pentose phosphate pathway # Organism EDD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21000 PTHR21000 # PATHWAY EDD_ECOLI Carbohydrate metabolism; Entner-Doudoroff pathway. # PATRIC 32119023 VBIEscCol129921_1929 # PIR A42986 A42986 # PROSITE PS00886 ILVD_EDD_1 # PROSITE PS00887 ILVD_EDD_2 # Pfam PF00920 ILVD_EDD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EDD_ECOLI Phosphogluconate dehydratase # RefSeq NP_416365 NC_000913.3 # RefSeq WP_001069467 NZ_LN832404.1 # SIMILARITY Belongs to the IlvD/Edd family. {ECO 0000305}. # SUPFAM SSF52016 SSF52016 # TIGRFAMs TIGR01196 edd # eggNOG COG0129 LUCA # eggNOG ENOG4105C01 Bacteria BLAST swissprot:EDD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EDD_ECOLI BioCyc ECOL316407:JW1840-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1840-MONOMER BioCyc EcoCyc:PGLUCONDEHYDRAT-MONOMER http://biocyc.org/getid?id=EcoCyc:PGLUCONDEHYDRAT-MONOMER BioCyc MetaCyc:PGLUCONDEHYDRAT-MONOMER http://biocyc.org/getid?id=MetaCyc:PGLUCONDEHYDRAT-MONOMER COG COG0129 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0129 DIP DIP-47906N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47906N DOI 10.1016/0378-1119(93)90362-7 http://dx.doi.org/10.1016/0378-1119(93)90362-7 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.1.12 http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.12 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L20897 http://www.ebi.ac.uk/ena/data/view/L20897 EMBL M87458 http://www.ebi.ac.uk/ena/data/view/M87458 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X63694 http://www.ebi.ac.uk/ena/data/view/X63694 ENZYME 4.2.1.12 http://enzyme.expasy.org/EC/4.2.1.12 EchoBASE EB0253 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0253 EcoGene EG10257 http://www.ecogene.org/geneInfo.php?eg_id=EG10257 EnsemblBacteria AAC74921 http://www.ensemblgenomes.org/id/AAC74921 EnsemblBacteria AAC74921 http://www.ensemblgenomes.org/id/AAC74921 EnsemblBacteria BAA15659 http://www.ensemblgenomes.org/id/BAA15659 EnsemblBacteria BAA15659 http://www.ensemblgenomes.org/id/BAA15659 EnsemblBacteria BAA15659 http://www.ensemblgenomes.org/id/BAA15659 EnsemblBacteria b1851 http://www.ensemblgenomes.org/id/b1851 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004456 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004456 GO_process GO:0009082 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009082 GO_process GO:0009255 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009255 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 946362 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946362 HOGENOM HOG000173157 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000173157&db=HOGENOM6 InParanoid P0ADF6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADF6 IntAct P0ADF6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADF6* IntEnz 4.2.1.12 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.12 InterPro IPR000581 http://www.ebi.ac.uk/interpro/entry/IPR000581 InterPro IPR004786 http://www.ebi.ac.uk/interpro/entry/IPR004786 InterPro IPR015928 http://www.ebi.ac.uk/interpro/entry/IPR015928 InterPro IPR020558 http://www.ebi.ac.uk/interpro/entry/IPR020558 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1840 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1840 KEGG_Gene eco:b1851 http://www.genome.jp/dbget-bin/www_bget?eco:b1851 KEGG_Orthology KO:K01690 http://www.genome.jp/dbget-bin/www_bget?KO:K01690 KEGG_Pathway ko00030 http://www.genome.jp/kegg-bin/show_pathway?ko00030 KEGG_Reaction rn:R02036 http://www.genome.jp/dbget-bin/www_bget?rn:R02036 OMA CQHEVEA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CQHEVEA PANTHER PTHR21000 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21000 PROSITE PS00886 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00886 PROSITE PS00887 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00887 PSORT swissprot:EDD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EDD_ECOLI PSORT-B swissprot:EDD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EDD_ECOLI PSORT2 swissprot:EDD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EDD_ECOLI Pfam PF00920 http://pfam.xfam.org/family/PF00920 Phobius swissprot:EDD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EDD_ECOLI PhylomeDB P0ADF6 http://phylomedb.org/?seqid=P0ADF6 ProteinModelPortal P0ADF6 http://www.proteinmodelportal.org/query/uniprot/P0ADF6 PubMed 1624451 http://www.ncbi.nlm.nih.gov/pubmed/1624451 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8344525 http://www.ncbi.nlm.nih.gov/pubmed/8344525 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416365 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416365 RefSeq WP_001069467 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001069467 SMR P0ADF6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADF6 STRING 511145.b1851 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1851&targetmode=cogs STRING COG0129 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0129&targetmode=cogs SUPFAM SSF52016 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52016 TIGRFAMs TIGR01196 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01196 UniProtKB EDD_ECOLI http://www.uniprot.org/uniprot/EDD_ECOLI UniProtKB-AC P0ADF6 http://www.uniprot.org/uniprot/P0ADF6 charge swissprot:EDD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EDD_ECOLI eggNOG COG0129 http://eggnogapi.embl.de/nog_data/html/tree/COG0129 eggNOG ENOG4105C01 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C01 epestfind swissprot:EDD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EDD_ECOLI garnier swissprot:EDD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EDD_ECOLI helixturnhelix swissprot:EDD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EDD_ECOLI hmoment swissprot:EDD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EDD_ECOLI iep swissprot:EDD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EDD_ECOLI inforesidue swissprot:EDD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EDD_ECOLI octanol swissprot:EDD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EDD_ECOLI pepcoil swissprot:EDD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EDD_ECOLI pepdigest swissprot:EDD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EDD_ECOLI pepinfo swissprot:EDD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EDD_ECOLI pepnet swissprot:EDD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EDD_ECOLI pepstats swissprot:EDD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EDD_ECOLI pepwheel swissprot:EDD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EDD_ECOLI pepwindow swissprot:EDD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EDD_ECOLI sigcleave swissprot:EDD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EDD_ECOLI ## Database ID URL or Descriptions # AltName TRPGD_ECOLI Anthranilate synthase, glutamine amidotransferase component # AltName TRPGD_ECOLI Anthranilate synthase, glutamine amidotransferase component # BIOPHYSICOCHEMICAL PROPERTIES TRPGD_ECOLI Kinetic parameters KM=1.2 uM for chorismate (at pH 7.5) {ECO 0000269|PubMed 2428387, ECO 0000269|PubMed 4567790, ECO 0000269|PubMed 5333199}; KM=5 uM for chorismate (at 25 degrees Celsius and at pH 7.8) {ECO 0000269|PubMed 2428387, ECO 0000269|PubMed 4567790, ECO 0000269|PubMed 5333199}; KM=360 uM for glutamine (at pH 7.5) {ECO 0000269|PubMed 2428387, ECO 0000269|PubMed 4567790, ECO 0000269|PubMed 5333199}; Vmax=0.53 nmol/min/mg enzyme (at 25 degrees Celsius and at pH 7.8) {ECO 0000269|PubMed 2428387, ECO 0000269|PubMed 4567790, ECO 0000269|PubMed 5333199}; # BioGrid 4260123 24 # CATALYTIC ACTIVITY TRPGD_ECOLI Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate. # CATALYTIC ACTIVITY TRPGD_ECOLI N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1- diphosphate. # ENZYME REGULATION TRPGD_ECOLI Cooperatively feedback inhibited by tryptophan. {ECO 0000269|PubMed 2428387, ECO 0000269|PubMed 4567790, ECO 0000269|PubMed 5333199}. # EcoGene EG11027 trpD # FUNCTION TRPGD_ECOLI Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. In addition to synthesizing anthranilate, it also catalyzes the second step of the pathway, the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate. {ECO 0000269|PubMed 2428387, ECO 0000269|PubMed 4567790, ECO 0000269|PubMed 5333199}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_component GO:0005950 anthranilate synthase complex; IBA:GO_Central. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0004048 anthranilate phosphoribosyltransferase activity; IDA:EcoCyc. # GO_function GO:0004049 anthranilate synthase activity; IDA:EcoCyc. # GO_process GO:0000162 tryptophan biosynthetic process; IDA:EcoCyc. # GO_process GO:0002047 phenazine biosynthetic process; IBA:GO_Central. # GO_process GO:0006541 glutamine metabolic process; IEA:UniProtKB-KW. # GO_process GO:0008652 cellular amino acid biosynthetic process; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.1030.10 -; 1. # Gene3D 3.40.50.880 -; 1. # HAMAP MF_00211 TrpD # InterPro IPR000312 Glycosyl_Trfase_fam3 # InterPro IPR005940 Anthranilate_Pribosyl_Tfrase # InterPro IPR006221 TrpG/PapA_dom # InterPro IPR017459 Glycosyl_Trfase_fam3_N_dom # InterPro IPR017926 GATASE # InterPro IPR029062 Class_I_gatase-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis # Organism TRPGD_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-tryptophan biosynthesis; L- tryptophan from chorismate step 1/5. # PATHWAY Amino-acid biosynthesis; L-tryptophan biosynthesis; L- tryptophan from chorismate step 2/5. # PATRIC 32117786 VBIEscCol129921_1313 # PIR B64874 NNEC2 # PROSITE PS51273 GATASE_TYPE_1 # Pfam PF00117 GATase # Pfam PF00591 Glycos_transf_3 # Pfam PF02885 Glycos_trans_3N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TRPGD_ECOLI Anthranilate phosphoribosyltransferase # RecName TRPGD_ECOLI Anthranilate synthase component 2 # RecName TRPGD_ECOLI Bifunctional protein TrpGD # RecName TRPGD_ECOLI Bifunctional protein TrpGD # RefSeq NP_415779 NC_000913.3 # RefSeq WP_000763511 NZ_LN832404.1 # SIMILARITY Contains 1 glutamine amidotransferase type-1 domain. {ECO 0000305}. # SIMILARITY In the C-terminal section; belongs to the anthranilate phosphoribosyltransferase family. {ECO 0000305}. # SUBUNIT Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE). {ECO 0000250}. # SUPFAM SSF47648 SSF47648 # SUPFAM SSF52317 SSF52317 # SUPFAM SSF52418 SSF52418 # TIGRFAMs TIGR00566 trpG_papA # TIGRFAMs TIGR01245 trpD # UniPathway UPA00035 UER00040 # UniPathway UPA00035 UER00041 # eggNOG COG0512 LUCA # eggNOG COG0547 LUCA # eggNOG ENOG4108EFP Bacteria BLAST swissprot:TRPGD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRPGD_ECOLI BioCyc ECOL316407:JW1255-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1255-MONOMER BioCyc EcoCyc:ANTHRANSYNCOMPII-MONOMER http://biocyc.org/getid?id=EcoCyc:ANTHRANSYNCOMPII-MONOMER BioCyc MetaCyc:ANTHRANSYNCOMPII-MONOMER http://biocyc.org/getid?id=MetaCyc:ANTHRANSYNCOMPII-MONOMER COG COG0512 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0512 COG COG0547 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0547 DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0022-2836(82)90326-6 http://dx.doi.org/10.1016/0022-2836(82)90326-6 DOI 10.1038/248048a0 http://dx.doi.org/10.1038/248048a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/9.24.6647 http://dx.doi.org/10.1093/nar/9.24.6647 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.4.2.18 http://www.genome.jp/dbget-bin/www_bget?EC:2.4.2.18 EC_number EC:4.1.3.27 http://www.genome.jp/dbget-bin/www_bget?EC:4.1.3.27 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01714 http://www.ebi.ac.uk/ena/data/view/J01714 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00367 http://www.ebi.ac.uk/ena/data/view/V00367 EMBL V00372 http://www.ebi.ac.uk/ena/data/view/V00372 ENZYME 2.4.2.18 http://enzyme.expasy.org/EC/2.4.2.18 ENZYME 4.1.3.27 http://enzyme.expasy.org/EC/4.1.3.27 EchoBASE EB1020 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1020 EcoGene EG11027 http://www.ecogene.org/geneInfo.php?eg_id=EG11027 EnsemblBacteria AAC74345 http://www.ensemblgenomes.org/id/AAC74345 EnsemblBacteria AAC74345 http://www.ensemblgenomes.org/id/AAC74345 EnsemblBacteria BAA14798 http://www.ensemblgenomes.org/id/BAA14798 EnsemblBacteria BAA14798 http://www.ensemblgenomes.org/id/BAA14798 EnsemblBacteria BAA14798 http://www.ensemblgenomes.org/id/BAA14798 EnsemblBacteria b1263 http://www.ensemblgenomes.org/id/b1263 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005950 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0004048 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004048 GO_function GO:0004049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004049 GO_process GO:0000162 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000162 GO_process GO:0002047 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002047 GO_process GO:0006541 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006541 GO_process GO:0008652 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008652 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.1030.10 http://www.cathdb.info/version/latest/superfamily/3.40.1030.10 Gene3D 3.40.50.880 http://www.cathdb.info/version/latest/superfamily/3.40.50.880 GeneID 945109 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945109 HAMAP MF_00211 http://hamap.expasy.org/unirule/MF_00211 HOGENOM HOG000230451 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000230451&db=HOGENOM6 InParanoid P00904 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00904 IntEnz 2.4.2.18 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.2.18 IntEnz 4.1.3.27 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.3.27 InterPro IPR000312 http://www.ebi.ac.uk/interpro/entry/IPR000312 InterPro IPR005940 http://www.ebi.ac.uk/interpro/entry/IPR005940 InterPro IPR006221 http://www.ebi.ac.uk/interpro/entry/IPR006221 InterPro IPR017459 http://www.ebi.ac.uk/interpro/entry/IPR017459 InterPro IPR017926 http://www.ebi.ac.uk/interpro/entry/IPR017926 InterPro IPR029062 http://www.ebi.ac.uk/interpro/entry/IPR029062 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1255 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1255 KEGG_Gene eco:b1263 http://www.genome.jp/dbget-bin/www_bget?eco:b1263 KEGG_Orthology KO:K13497 http://www.genome.jp/dbget-bin/www_bget?KO:K13497 KEGG_Pathway ko00400 http://www.genome.jp/kegg-bin/show_pathway?ko00400 KEGG_Reaction rn:R00985 http://www.genome.jp/dbget-bin/www_bget?rn:R00985 KEGG_Reaction rn:R00986 http://www.genome.jp/dbget-bin/www_bget?rn:R00986 KEGG_Reaction rn:R01073 http://www.genome.jp/dbget-bin/www_bget?rn:R01073 OMA VIYRNHV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VIYRNHV PROSITE PS51273 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51273 PSORT swissprot:TRPGD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRPGD_ECOLI PSORT-B swissprot:TRPGD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRPGD_ECOLI PSORT2 swissprot:TRPGD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRPGD_ECOLI Pfam PF00117 http://pfam.xfam.org/family/PF00117 Pfam PF00591 http://pfam.xfam.org/family/PF00591 Pfam PF02885 http://pfam.xfam.org/family/PF02885 Phobius swissprot:TRPGD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRPGD_ECOLI PhylomeDB P00904 http://phylomedb.org/?seqid=P00904 ProteinModelPortal P00904 http://www.proteinmodelportal.org/query/uniprot/P00904 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2428387 http://www.ncbi.nlm.nih.gov/pubmed/2428387 PubMed 4567790 http://www.ncbi.nlm.nih.gov/pubmed/4567790 PubMed 4594441 http://www.ncbi.nlm.nih.gov/pubmed/4594441 PubMed 5333199 http://www.ncbi.nlm.nih.gov/pubmed/5333199 PubMed 6283099 http://www.ncbi.nlm.nih.gov/pubmed/6283099 PubMed 7038627 http://www.ncbi.nlm.nih.gov/pubmed/7038627 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_415779 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415779 RefSeq WP_000763511 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000763511 SMR P00904 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00904 STRING 511145.b1263 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1263&targetmode=cogs STRING COG0512 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0512&targetmode=cogs STRING COG0547 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0547&targetmode=cogs SUPFAM SSF47648 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47648 SUPFAM SSF52317 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52317 SUPFAM SSF52418 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52418 SWISS-2DPAGE P00904 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P00904 TIGRFAMs TIGR00566 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00566 TIGRFAMs TIGR01245 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01245 UniProtKB TRPGD_ECOLI http://www.uniprot.org/uniprot/TRPGD_ECOLI UniProtKB-AC P00904 http://www.uniprot.org/uniprot/P00904 charge swissprot:TRPGD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRPGD_ECOLI eggNOG COG0512 http://eggnogapi.embl.de/nog_data/html/tree/COG0512 eggNOG COG0547 http://eggnogapi.embl.de/nog_data/html/tree/COG0547 eggNOG ENOG4108EFP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108EFP epestfind swissprot:TRPGD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRPGD_ECOLI garnier swissprot:TRPGD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRPGD_ECOLI helixturnhelix swissprot:TRPGD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRPGD_ECOLI hmoment swissprot:TRPGD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRPGD_ECOLI iep swissprot:TRPGD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRPGD_ECOLI inforesidue swissprot:TRPGD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRPGD_ECOLI octanol swissprot:TRPGD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRPGD_ECOLI pepcoil swissprot:TRPGD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRPGD_ECOLI pepdigest swissprot:TRPGD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRPGD_ECOLI pepinfo swissprot:TRPGD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRPGD_ECOLI pepnet swissprot:TRPGD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRPGD_ECOLI pepstats swissprot:TRPGD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRPGD_ECOLI pepwheel swissprot:TRPGD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRPGD_ECOLI pepwindow swissprot:TRPGD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRPGD_ECOLI sigcleave swissprot:TRPGD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRPGD_ECOLI ## Database ID URL or Descriptions # BioGrid 4259494 280 # EcoGene EG10677 oppD # FUNCTION OPPD_ECOLI Part of the binding-protein-dependent transport system for oligopeptides. Probably responsible for energy coupling to the transport system. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016887 ATPase activity; IEA:InterPro. # GO_process GO:0015031 protein transport; IEA:UniProtKB-KW. # GO_process GO:0015833 peptide transport; IEA:UniProtKB-KW. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # Gene3D 3.40.50.300 -; 1. # IntAct P76027 3 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR013563 Oligopep_ABC_C # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00439 Oligopeptide transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism OPPD_ECOLI Escherichia coli (strain K12) # PATRIC 32117752 VBIEscCol129921_1296 # PIR A64872 A64872 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # Pfam PF00005 ABC_tran # Pfam PF08352 oligo_HPY # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName OPPD_ECOLI Oligopeptide transport ATP-binding protein OppD # RefSeq WP_000110948 NZ_LN832404.1 # RefSeq YP_025300 NC_000913.3 # SIMILARITY Belongs to the ABC transporter superfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA # SUBCELLULAR LOCATION OPPD_ECOLI Cell inner membrane; Peripheral membrane protein. # SUPFAM SSF52540 SSF52540 # TCDB 3.A.1.5.41 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR01727 oligo_HPY # eggNOG COG0444 LUCA # eggNOG ENOG4105C3U Bacteria BLAST swissprot:OPPD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:OPPD_ECOLI BioCyc ECOL316407:JW1238-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1238-MONOMER BioCyc EcoCyc:OPPD-MONOMER http://biocyc.org/getid?id=EcoCyc:OPPD-MONOMER BioCyc MetaCyc:OPPD-MONOMER http://biocyc.org/getid?id=MetaCyc:OPPD-MONOMER COG COG0444 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0444 DIP DIP-10408N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10408N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0671 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0671 EcoGene EG10677 http://www.ecogene.org/geneInfo.php?eg_id=EG10677 EnsemblBacteria AAT48129 http://www.ensemblgenomes.org/id/AAT48129 EnsemblBacteria AAT48129 http://www.ensemblgenomes.org/id/AAT48129 EnsemblBacteria BAA14778 http://www.ensemblgenomes.org/id/BAA14778 EnsemblBacteria BAA14778 http://www.ensemblgenomes.org/id/BAA14778 EnsemblBacteria BAA14778 http://www.ensemblgenomes.org/id/BAA14778 EnsemblBacteria b1246 http://www.ensemblgenomes.org/id/b1246 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_process GO:0015031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031 GO_process GO:0015833 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015833 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945802 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945802 InParanoid P76027 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76027 IntAct P76027 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76027* InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR013563 http://www.ebi.ac.uk/interpro/entry/IPR013563 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1238 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1238 KEGG_Gene eco:b1246 http://www.genome.jp/dbget-bin/www_bget?eco:b1246 KEGG_Orthology KO:K15583 http://www.genome.jp/dbget-bin/www_bget?KO:K15583 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 MINT MINT-1300671 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1300671 OMA FQPRCQF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FQPRCQF PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:OPPD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:OPPD_ECOLI PSORT-B swissprot:OPPD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:OPPD_ECOLI PSORT2 swissprot:OPPD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:OPPD_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Pfam PF08352 http://pfam.xfam.org/family/PF08352 Phobius swissprot:OPPD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:OPPD_ECOLI PhylomeDB P76027 http://phylomedb.org/?seqid=P76027 ProteinModelPortal P76027 http://www.proteinmodelportal.org/query/uniprot/P76027 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000110948 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000110948 RefSeq YP_025300 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_025300 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P76027 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76027 STRING 511145.b1246 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1246&targetmode=cogs STRING COG0444 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0444&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.5.41 http://www.tcdb.org/search/result.php?tc=3.A.1.5.41 TIGRFAMs TIGR01727 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01727 UniProtKB OPPD_ECOLI http://www.uniprot.org/uniprot/OPPD_ECOLI UniProtKB-AC P76027 http://www.uniprot.org/uniprot/P76027 charge swissprot:OPPD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:OPPD_ECOLI eggNOG COG0444 http://eggnogapi.embl.de/nog_data/html/tree/COG0444 eggNOG ENOG4105C3U http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C3U epestfind swissprot:OPPD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:OPPD_ECOLI garnier swissprot:OPPD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:OPPD_ECOLI helixturnhelix swissprot:OPPD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:OPPD_ECOLI hmoment swissprot:OPPD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:OPPD_ECOLI iep swissprot:OPPD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:OPPD_ECOLI inforesidue swissprot:OPPD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:OPPD_ECOLI octanol swissprot:OPPD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:OPPD_ECOLI pepcoil swissprot:OPPD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:OPPD_ECOLI pepdigest swissprot:OPPD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:OPPD_ECOLI pepinfo swissprot:OPPD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:OPPD_ECOLI pepnet swissprot:OPPD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:OPPD_ECOLI pepstats swissprot:OPPD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:OPPD_ECOLI pepwheel swissprot:OPPD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:OPPD_ECOLI pepwindow swissprot:OPPD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:OPPD_ECOLI sigcleave swissprot:OPPD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:OPPD_ECOLI ## Database ID URL or Descriptions # AltName RIHC_ECOLI Purine/pyrimidine ribonucleoside hydrolase # BioGrid 4261497 10 # ENZYME REGULATION RIHC_ECOLI Subject to catabolite repression. # EcoGene EG11082 rihC # FUNCTION RIHC_ECOLI Hydrolyzes both purine and pyrimidine ribonucleosides with a broad-substrate specificity with decreasing activity in the order uridine, xanthosine, inosine, adenosine, cytidine, guanosine. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0045437 uridine nucleosidase activity; IDA:EcoCyc. # GO_function GO:0047622 adenosine nucleosidase activity; IDA:EcoCyc. # GO_function GO:0047724 inosine nucleosidase activity; IDA:EcoCyc. # GO_function GO:0050263 ribosylpyrimidine nucleosidase activity; IDA:EcoCyc. # GO_process GO:0006144 purine nucleobase metabolic process; IEA:UniProtKB-HAMAP. # GO_process GO:0006152 purine nucleoside catabolic process; IBA:GO_Central. # GO_process GO:0006206 pyrimidine nucleobase metabolic process; IEA:UniProtKB-HAMAP. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0042454 ribonucleoside catabolic process; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_process GO:0006950 response to stress # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.90.245.10 -; 1. # HAMAP MF_01432 Nucleosid_hydro_RihC # IntAct P22564 2 # InterPro IPR001910 Inosine/uridine_hydrolase_dom # InterPro IPR015910 I/U_nuclsd_hydro_CS # InterPro IPR022976 Nucleosid_hydro_RihC_nonspecif # InterPro IPR023186 Inosine/uridine_hydrolase # KEGG_Brite ko01000 Enzymes # MISCELLANEOUS RIHC_ECOLI Strictly specific for ribonucleosides. # Organism RIHC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR12304 PTHR12304 # PATRIC 32115151 VBIEscCol129921_0027 # PIR JE0404 JE0404 # PROSITE PS01247 IUNH # Pfam PF01156 IU_nuc_hydro # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RIHC_ECOLI Non-specific ribonucleoside hydrolase RihC # RefSeq NP_414571 NC_000913.3 # RefSeq WP_001239142 NZ_LN832404.1 # SIMILARITY Belongs to the IUNH family. RihC subfamily. {ECO 0000305}. # SUPFAM SSF53590 SSF53590 # eggNOG COG1957 LUCA # eggNOG ENOG4105DU0 Bacteria BLAST swissprot:RIHC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RIHC_ECOLI BioCyc ECOL316407:JW0028-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0028-MONOMER BioCyc EcoCyc:EG11082-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11082-MONOMER BioCyc MetaCyc:EG11082-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11082-MONOMER COG COG1957 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1957 DIP DIP-11157N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11157N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M008300200 http://dx.doi.org/10.1074/jbc.M008300200 DOI 10.1093/nar/19.1.180 http://dx.doi.org/10.1093/nar/19.1.180 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.2.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.2.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X54945 http://www.ebi.ac.uk/ena/data/view/X54945 ENZYME 3.2.-.- http://enzyme.expasy.org/EC/3.2.-.- EchoBASE EB1074 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1074 EcoGene EG11082 http://www.ecogene.org/geneInfo.php?eg_id=EG11082 EnsemblBacteria AAC73141 http://www.ensemblgenomes.org/id/AAC73141 EnsemblBacteria AAC73141 http://www.ensemblgenomes.org/id/AAC73141 EnsemblBacteria BAB96599 http://www.ensemblgenomes.org/id/BAB96599 EnsemblBacteria BAB96599 http://www.ensemblgenomes.org/id/BAB96599 EnsemblBacteria BAB96599 http://www.ensemblgenomes.org/id/BAB96599 EnsemblBacteria b0030 http://www.ensemblgenomes.org/id/b0030 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0045437 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045437 GO_function GO:0047622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047622 GO_function GO:0047724 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047724 GO_function GO:0050263 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050263 GO_process GO:0006144 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006144 GO_process GO:0006152 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006152 GO_process GO:0006206 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006206 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0042454 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042454 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.90.245.10 http://www.cathdb.info/version/latest/superfamily/3.90.245.10 GeneID 944796 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944796 HAMAP MF_01432 http://hamap.expasy.org/unirule/MF_01432 HOGENOM HOG000218839 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218839&db=HOGENOM6 InParanoid P22564 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P22564 IntAct P22564 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P22564* IntEnz 3.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.2 InterPro IPR001910 http://www.ebi.ac.uk/interpro/entry/IPR001910 InterPro IPR015910 http://www.ebi.ac.uk/interpro/entry/IPR015910 InterPro IPR022976 http://www.ebi.ac.uk/interpro/entry/IPR022976 InterPro IPR023186 http://www.ebi.ac.uk/interpro/entry/IPR023186 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0028 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0028 KEGG_Gene eco:b0030 http://www.genome.jp/dbget-bin/www_bget?eco:b0030 KEGG_Orthology KO:K12700 http://www.genome.jp/dbget-bin/www_bget?KO:K12700 MINT MINT-1268238 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1268238 OMA IKRLVMM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IKRLVMM PANTHER PTHR12304 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12304 PROSITE PS01247 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01247 PSORT swissprot:RIHC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RIHC_ECOLI PSORT-B swissprot:RIHC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RIHC_ECOLI PSORT2 swissprot:RIHC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RIHC_ECOLI Pfam PF01156 http://pfam.xfam.org/family/PF01156 Phobius swissprot:RIHC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RIHC_ECOLI PhylomeDB P22564 http://phylomedb.org/?seqid=P22564 ProteinModelPortal P22564 http://www.proteinmodelportal.org/query/uniprot/P22564 PubMed 11027694 http://www.ncbi.nlm.nih.gov/pubmed/11027694 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2011499 http://www.ncbi.nlm.nih.gov/pubmed/2011499 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414571 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414571 RefSeq WP_001239142 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001239142 SMR P22564 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P22564 STRING 511145.b0030 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0030&targetmode=cogs STRING COG1957 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1957&targetmode=cogs SUPFAM SSF53590 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53590 UniProtKB RIHC_ECOLI http://www.uniprot.org/uniprot/RIHC_ECOLI UniProtKB-AC P22564 http://www.uniprot.org/uniprot/P22564 charge swissprot:RIHC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RIHC_ECOLI eggNOG COG1957 http://eggnogapi.embl.de/nog_data/html/tree/COG1957 eggNOG ENOG4105DU0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DU0 epestfind swissprot:RIHC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RIHC_ECOLI garnier swissprot:RIHC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RIHC_ECOLI helixturnhelix swissprot:RIHC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RIHC_ECOLI hmoment swissprot:RIHC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RIHC_ECOLI iep swissprot:RIHC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RIHC_ECOLI inforesidue swissprot:RIHC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RIHC_ECOLI octanol swissprot:RIHC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RIHC_ECOLI pepcoil swissprot:RIHC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RIHC_ECOLI pepdigest swissprot:RIHC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RIHC_ECOLI pepinfo swissprot:RIHC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RIHC_ECOLI pepnet swissprot:RIHC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RIHC_ECOLI pepstats swissprot:RIHC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RIHC_ECOLI pepwheel swissprot:RIHC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RIHC_ECOLI pepwindow swissprot:RIHC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RIHC_ECOLI sigcleave swissprot:RIHC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RIHC_ECOLI ## Database ID URL or Descriptions # AltName DMLR_ECOLI D-malate degradation protein R # BioGrid 4260334 12 # DISRUPTION PHENOTYPE DMLR_ECOLI Deletion of dmlR inhibits aerobic growth on D-malate and inhibits the induction of dmlA expression by D-malate and L- and meso-tartrate. {ECO 0000269|PubMed 17088549, ECO 0000269|PubMed 20233924}. # EcoGene EG13506 dmlR # FUNCTION DMLR_ECOLI Transcriptional regulator required for the aerobic growth on D-malate as the sole carbon source. Induces the expression of dmlA in response to D-malate or L- or meso-tartrate. Negatively regulates its own expression. {ECO 0000269|PubMed 17088549, ECO 0000269|PubMed 20233924}. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IMP:UniProtKB. # GO_function GO:0043565 sequence-specific DNA binding; IBA:GO_Central. # GO_process GO:0006108 malate metabolic process; IMP:UniProtKB. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IMP:UniProtKB. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IMP:UniProtKB. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.10.10 -; 1. # INDUCTION Expression of dmlR is subject to negative autoregulation under both aerobic and anaerobic growth conditions. Its level of expression is generally lower under anaerobic conditions than that under aerobic conditions. {ECO:0000269|PubMed 20233924}. # IntAct P76250 13 # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR005119 LysR_subst-bd # InterPro IPR011991 WHTH_DNA-bd_dom # KEGG_Brite ko03000 Transcription factors # Organism DMLR_ECOLI Escherichia coli (strain K12) # PATRIC 32118915 VBIEscCol129921_1875 # PIR G64940 G64940 # PROSITE PS50931 HTH_LYSR # Pfam PF00126 HTH_1 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DMLR_ECOLI HTH-type transcriptional regulator DmlR # RefSeq NP_416313 NC_000913.3 # RefSeq WP_001061575 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lysR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00253}. # SUPFAM SSF46785 SSF46785 # eggNOG ENOG4105EJC Bacteria # eggNOG ENOG410XNQA LUCA BLAST swissprot:DMLR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DMLR_ECOLI BioCyc ECOL316407:JW1788-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1788-MONOMER BioCyc EcoCyc:G6985-MONOMER http://biocyc.org/getid?id=EcoCyc:G6985-MONOMER COG COG0583 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0583 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0603364103 http://dx.doi.org/10.1073/pnas.0603364103 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01665-09 http://dx.doi.org/10.1128/JB.01665-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3279 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3279 EcoGene EG13506 http://www.ecogene.org/geneInfo.php?eg_id=EG13506 EnsemblBacteria AAC74869 http://www.ensemblgenomes.org/id/AAC74869 EnsemblBacteria AAC74869 http://www.ensemblgenomes.org/id/AAC74869 EnsemblBacteria BAA15594 http://www.ensemblgenomes.org/id/BAA15594 EnsemblBacteria BAA15594 http://www.ensemblgenomes.org/id/BAA15594 EnsemblBacteria BAA15594 http://www.ensemblgenomes.org/id/BAA15594 EnsemblBacteria b1799 http://www.ensemblgenomes.org/id/b1799 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006108 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006108 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 946316 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946316 HOGENOM HOG000233519 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000233519&db=HOGENOM6 InParanoid P76250 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76250 IntAct P76250 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76250* InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW1788 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1788 KEGG_Gene eco:b1799 http://www.genome.jp/dbget-bin/www_bget?eco:b1799 KEGG_Orthology KO:K16135 http://www.genome.jp/dbget-bin/www_bget?KO:K16135 OMA QLEIRFD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QLEIRFD PROSITE PS50931 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50931 PSORT swissprot:DMLR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DMLR_ECOLI PSORT-B swissprot:DMLR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DMLR_ECOLI PSORT2 swissprot:DMLR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DMLR_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:DMLR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DMLR_ECOLI PhylomeDB P76250 http://phylomedb.org/?seqid=P76250 ProteinModelPortal P76250 http://www.proteinmodelportal.org/query/uniprot/P76250 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17088549 http://www.ncbi.nlm.nih.gov/pubmed/17088549 PubMed 20233924 http://www.ncbi.nlm.nih.gov/pubmed/20233924 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416313 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416313 RefSeq WP_001061575 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001061575 SMR P76250 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76250 STRING 511145.b1799 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1799&targetmode=cogs STRING COG0583 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0583&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB DMLR_ECOLI http://www.uniprot.org/uniprot/DMLR_ECOLI UniProtKB-AC P76250 http://www.uniprot.org/uniprot/P76250 charge swissprot:DMLR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DMLR_ECOLI eggNOG ENOG4105EJC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EJC eggNOG ENOG410XNQA http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNQA epestfind swissprot:DMLR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DMLR_ECOLI garnier swissprot:DMLR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DMLR_ECOLI helixturnhelix swissprot:DMLR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DMLR_ECOLI hmoment swissprot:DMLR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DMLR_ECOLI iep swissprot:DMLR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DMLR_ECOLI inforesidue swissprot:DMLR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DMLR_ECOLI octanol swissprot:DMLR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DMLR_ECOLI pepcoil swissprot:DMLR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DMLR_ECOLI pepdigest swissprot:DMLR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DMLR_ECOLI pepinfo swissprot:DMLR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DMLR_ECOLI pepnet swissprot:DMLR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DMLR_ECOLI pepstats swissprot:DMLR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DMLR_ECOLI pepwheel swissprot:DMLR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DMLR_ECOLI pepwindow swissprot:DMLR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DMLR_ECOLI sigcleave swissprot:DMLR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DMLR_ECOLI ## Database ID URL or Descriptions # AltName YAFL_ECOLI Uncharacterized lipoprotein YafL # BioGrid 4259761 264 # EcoGene EG13149 yafL # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_function GO:0008234 cysteine-type peptidase activity; IEA:UniProtKB-KW. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0008233 peptidase activity # Gene3D 3.90.1720.10 -; 1. # IntAct Q47151 6 # InterPro IPR000064 NLP_P60_dom # Organism YAFL_ECOLI Escherichia coli (strain K12) # PATRIC 32115569 VBIEscCol129921_0229 # PIR D64747 D64747 # Pfam PF00877 NLPC_P60 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAFL_ECOLI Probable endopeptidase YafL # RefSeq NP_414762 NC_000913.3 # RefSeq WP_000056849 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase C40 family. {ECO 0000305}. # SUBCELLULAR LOCATION YAFL_ECOLI Cell membrane {ECO 0000305}; Lipid-anchor {ECO 0000305}. # eggNOG COG0791 LUCA # eggNOG ENOG4108YS0 Bacteria BLAST swissprot:YAFL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAFL_ECOLI BioCyc ECOL316407:JW0217-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0217-MONOMER BioCyc EcoCyc:G6111-MONOMER http://biocyc.org/getid?id=EcoCyc:G6111-MONOMER DOI 10.1016/0165-7992(95)90024-1 http://dx.doi.org/10.1016/0165-7992(95)90024-1 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.4.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D38582 http://www.ebi.ac.uk/ena/data/view/D38582 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 ENZYME 3.4.-.- http://enzyme.expasy.org/EC/3.4.-.- EchoBASE EB2943 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2943 EcoGene EG13149 http://www.ecogene.org/geneInfo.php?eg_id=EG13149 EnsemblBacteria AAC73331 http://www.ensemblgenomes.org/id/AAC73331 EnsemblBacteria AAC73331 http://www.ensemblgenomes.org/id/AAC73331 EnsemblBacteria BAA77897 http://www.ensemblgenomes.org/id/BAA77897 EnsemblBacteria BAA77897 http://www.ensemblgenomes.org/id/BAA77897 EnsemblBacteria BAA77897 http://www.ensemblgenomes.org/id/BAA77897 EnsemblBacteria b0227 http://www.ensemblgenomes.org/id/b0227 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0008234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008234 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 Gene3D 3.90.1720.10 http://www.cathdb.info/version/latest/superfamily/3.90.1720.10 GeneID 944899 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944899 HOGENOM HOG000229978 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000229978&db=HOGENOM6 InParanoid Q47151 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q47151 IntAct Q47151 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q47151* IntEnz 3.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4 InterPro IPR000064 http://www.ebi.ac.uk/interpro/entry/IPR000064 KEGG_Gene ecj:JW0217 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0217 KEGG_Gene eco:b0227 http://www.genome.jp/dbget-bin/www_bget?eco:b0227 OMA RYGPGYT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RYGPGYT PSORT swissprot:YAFL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAFL_ECOLI PSORT-B swissprot:YAFL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAFL_ECOLI PSORT2 swissprot:YAFL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAFL_ECOLI Pfam PF00877 http://pfam.xfam.org/family/PF00877 Phobius swissprot:YAFL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAFL_ECOLI PhylomeDB Q47151 http://phylomedb.org/?seqid=Q47151 ProteinModelPortal Q47151 http://www.proteinmodelportal.org/query/uniprot/Q47151 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7596361 http://www.ncbi.nlm.nih.gov/pubmed/7596361 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414762 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414762 RefSeq WP_000056849 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000056849 SMR Q47151 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q47151 STRING 511145.b0227 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0227&targetmode=cogs UniProtKB YAFL_ECOLI http://www.uniprot.org/uniprot/YAFL_ECOLI UniProtKB-AC Q47151 http://www.uniprot.org/uniprot/Q47151 charge swissprot:YAFL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAFL_ECOLI eggNOG COG0791 http://eggnogapi.embl.de/nog_data/html/tree/COG0791 eggNOG ENOG4108YS0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108YS0 epestfind swissprot:YAFL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAFL_ECOLI garnier swissprot:YAFL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAFL_ECOLI helixturnhelix swissprot:YAFL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAFL_ECOLI hmoment swissprot:YAFL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAFL_ECOLI iep swissprot:YAFL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAFL_ECOLI inforesidue swissprot:YAFL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAFL_ECOLI octanol swissprot:YAFL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAFL_ECOLI pepcoil swissprot:YAFL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAFL_ECOLI pepdigest swissprot:YAFL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAFL_ECOLI pepinfo swissprot:YAFL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAFL_ECOLI pepnet swissprot:YAFL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAFL_ECOLI pepstats swissprot:YAFL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAFL_ECOLI pepwheel swissprot:YAFL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAFL_ECOLI pepwindow swissprot:YAFL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAFL_ECOLI sigcleave swissprot:YAFL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAFL_ECOLI ## Database ID URL or Descriptions # BioGrid 4261873 136 # EcoGene EG12670 dinI # FUNCTION DINI_ECOLI Involved in SOS regulation. Inhibits RecA by preventing RecA to bind ssDNA. Can displace ssDNA from RecA. # GO_function GO:0019899 enzyme binding; IPI:EcoCyc. # GO_process GO:0006281 DNA repair; IEA:UniProtKB-KW. # GO_process GO:0009432 SOS response; IDA:EcoCyc. # GOslim_function GO:0019899 enzyme binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # Gene3D 3.30.910.10 -; 1. # InterPro IPR010391 DNA_damage-inducible_DinI-like # Organism DINI_ECOLI Escherichia coli (strain K12) # PATRIC 32117361 VBIEscCol129921_1103 # PDB 1GHH NMR; -; A=1-81 # PIR B64849 B64849 # Pfam PF06183 DinI # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DINI_ECOLI DNA-damage-inducible protein I # RefSeq NP_415579 NC_000913.3 # RefSeq WP_001217754 NZ_LN832404.1 # SIMILARITY Belongs to the DinI family. {ECO 0000305}. # SUPFAM SSF54857 SSF54857 # eggNOG ENOG4105MEA Bacteria # eggNOG ENOG4111VX8 LUCA BLAST swissprot:DINI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DINI_ECOLI BioCyc ECOL316407:JW1048-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1048-MONOMER BioCyc EcoCyc:G6558-MONOMER http://biocyc.org/getid?id=EcoCyc:G6558-MONOMER DIP DIP-9445N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9445N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1101/gad.862901 http://dx.doi.org/10.1101/gad.862901 DOI 10.1110/ps.9.11.2161 http://dx.doi.org/10.1110/ps.9.11.2161 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D31709 http://www.ebi.ac.uk/ena/data/view/D31709 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2536 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2536 EcoGene EG12670 http://www.ecogene.org/geneInfo.php?eg_id=EG12670 EnsemblBacteria AAC74145 http://www.ensemblgenomes.org/id/AAC74145 EnsemblBacteria AAC74145 http://www.ensemblgenomes.org/id/AAC74145 EnsemblBacteria BAA35858 http://www.ensemblgenomes.org/id/BAA35858 EnsemblBacteria BAA35858 http://www.ensemblgenomes.org/id/BAA35858 EnsemblBacteria BAA35858 http://www.ensemblgenomes.org/id/BAA35858 EnsemblBacteria b1061 http://www.ensemblgenomes.org/id/b1061 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0019899 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899 GO_process GO:0006281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006281 GO_process GO:0009432 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009432 GOslim_function GO:0019899 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.30.910.10 http://www.cathdb.info/version/latest/superfamily/3.30.910.10 GeneID 945022 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945022 HOGENOM HOG000276614 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276614&db=HOGENOM6 InterPro IPR010391 http://www.ebi.ac.uk/interpro/entry/IPR010391 KEGG_Gene ecj:JW1048 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1048 KEGG_Gene eco:b1061 http://www.genome.jp/dbget-bin/www_bget?eco:b1061 KEGG_Orthology KO:K12149 http://www.genome.jp/dbget-bin/www_bget?KO:K12149 OMA TPWCHSS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TPWCHSS PDB 1GHH http://www.ebi.ac.uk/pdbe-srv/view/entry/1GHH PDBsum 1GHH http://www.ebi.ac.uk/pdbsum/1GHH PSORT swissprot:DINI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DINI_ECOLI PSORT-B swissprot:DINI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DINI_ECOLI PSORT2 swissprot:DINI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DINI_ECOLI Pfam PF06183 http://pfam.xfam.org/family/PF06183 Phobius swissprot:DINI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DINI_ECOLI ProteinModelPortal P0ABR1 http://www.proteinmodelportal.org/query/uniprot/P0ABR1 PubMed 11152126 http://www.ncbi.nlm.nih.gov/pubmed/11152126 PubMed 11230150 http://www.ncbi.nlm.nih.gov/pubmed/11230150 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8682790 http://www.ncbi.nlm.nih.gov/pubmed/8682790 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415579 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415579 RefSeq WP_001217754 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001217754 SMR P0ABR1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABR1 STRING 511145.b1061 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1061&targetmode=cogs SUPFAM SSF54857 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54857 UniProtKB DINI_ECOLI http://www.uniprot.org/uniprot/DINI_ECOLI UniProtKB-AC P0ABR1 http://www.uniprot.org/uniprot/P0ABR1 charge swissprot:DINI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DINI_ECOLI eggNOG ENOG4105MEA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105MEA eggNOG ENOG4111VX8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111VX8 epestfind swissprot:DINI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DINI_ECOLI garnier swissprot:DINI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DINI_ECOLI helixturnhelix swissprot:DINI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DINI_ECOLI hmoment swissprot:DINI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DINI_ECOLI iep swissprot:DINI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DINI_ECOLI inforesidue swissprot:DINI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DINI_ECOLI octanol swissprot:DINI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DINI_ECOLI pepcoil swissprot:DINI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DINI_ECOLI pepdigest swissprot:DINI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DINI_ECOLI pepinfo swissprot:DINI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DINI_ECOLI pepnet swissprot:DINI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DINI_ECOLI pepstats swissprot:DINI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DINI_ECOLI pepwheel swissprot:DINI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DINI_ECOLI pepwindow swissprot:DINI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DINI_ECOLI sigcleave swissprot:DINI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DINI_ECOLI ## Database ID URL or Descriptions # AltName PGRR_ECOLI Regulator of PG recycling # BioGrid 4260154 13 # EcoGene EG13923 pgrR # FUNCTION PGRR_ECOLI Regulates the expression of genes involved in peptidoglycan (PG) degradation. Could play a role in switch control between recycling and degradation of PG peptides. Negatively regulates the expression of the ycjY-ymjD-ymjC-mpaA operon by binding to the PgrR-box. In addition, other genes are predicted to be under the control of PgrR, including genes related to membrane formation and function. {ECO 0000269|PubMed 23301696}. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0043565 sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0071978 bacterial-type flagellum-dependent swarming motility; IMP:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0048870 cell motility # Gene3D 1.10.10.10 -; 1. # IntAct P77333 7 # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR005119 LysR_subst-bd # InterPro IPR011991 WHTH_DNA-bd_dom # Organism PGRR_ECOLI Escherichia coli (strain K12) # PATRIC 32117932 VBIEscCol129921_1386 # PIR C64882 C64882 # PRINTS PR00039 HTHLYSR # PROSITE PS50931 HTH_LYSR # Pfam PF00126 HTH_1 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PGRR_ECOLI HTH-type transcriptional regulator PgrR # RefSeq NP_415844 NC_000913.3 # RefSeq WP_000817708 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lysR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00253}. # SUPFAM SSF46785 SSF46785 # eggNOG ENOG4105EQ2 Bacteria # eggNOG ENOG410XRUN LUCA BLAST swissprot:PGRR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PGRR_ECOLI BioCyc ECOL316407:JW1321-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1321-MONOMER BioCyc EcoCyc:G6664-MONOMER http://biocyc.org/getid?id=EcoCyc:G6664-MONOMER DIP DIP-11617N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11617N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1111/gtc.12026 http://dx.doi.org/10.1111/gtc.12026 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3682 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3682 EcoGene EG13923 http://www.ecogene.org/geneInfo.php?eg_id=EG13923 EnsemblBacteria AAC74410 http://www.ensemblgenomes.org/id/AAC74410 EnsemblBacteria AAC74410 http://www.ensemblgenomes.org/id/AAC74410 EnsemblBacteria BAA14921 http://www.ensemblgenomes.org/id/BAA14921 EnsemblBacteria BAA14921 http://www.ensemblgenomes.org/id/BAA14921 EnsemblBacteria BAA14921 http://www.ensemblgenomes.org/id/BAA14921 EnsemblBacteria b1328 http://www.ensemblgenomes.org/id/b1328 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GO_process GO:0071978 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071978 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 945930 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945930 HOGENOM HOG000233519 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000233519&db=HOGENOM6 InParanoid P77333 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77333 IntAct P77333 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77333* InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW1321 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1321 KEGG_Gene eco:b1328 http://www.genome.jp/dbget-bin/www_bget?eco:b1328 OMA SERFDAC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SERFDAC PRINTS PR00039 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00039 PROSITE PS50931 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50931 PSORT swissprot:PGRR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PGRR_ECOLI PSORT-B swissprot:PGRR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PGRR_ECOLI PSORT2 swissprot:PGRR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PGRR_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:PGRR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PGRR_ECOLI PhylomeDB P77333 http://phylomedb.org/?seqid=P77333 ProteinModelPortal P77333 http://www.proteinmodelportal.org/query/uniprot/P77333 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 23301696 http://www.ncbi.nlm.nih.gov/pubmed/23301696 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415844 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415844 RefSeq WP_000817708 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000817708 SMR P77333 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77333 STRING 511145.b1328 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1328&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB PGRR_ECOLI http://www.uniprot.org/uniprot/PGRR_ECOLI UniProtKB-AC P77333 http://www.uniprot.org/uniprot/P77333 charge swissprot:PGRR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PGRR_ECOLI eggNOG ENOG4105EQ2 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EQ2 eggNOG ENOG410XRUN http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XRUN epestfind swissprot:PGRR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PGRR_ECOLI garnier swissprot:PGRR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PGRR_ECOLI helixturnhelix swissprot:PGRR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PGRR_ECOLI hmoment swissprot:PGRR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PGRR_ECOLI iep swissprot:PGRR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PGRR_ECOLI inforesidue swissprot:PGRR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PGRR_ECOLI octanol swissprot:PGRR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PGRR_ECOLI pepcoil swissprot:PGRR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PGRR_ECOLI pepdigest swissprot:PGRR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PGRR_ECOLI pepinfo swissprot:PGRR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PGRR_ECOLI pepnet swissprot:PGRR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PGRR_ECOLI pepstats swissprot:PGRR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PGRR_ECOLI pepwheel swissprot:PGRR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PGRR_ECOLI pepwindow swissprot:PGRR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PGRR_ECOLI sigcleave swissprot:PGRR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PGRR_ECOLI ## Database ID URL or Descriptions # BioGrid 4262450 211 # CATALYTIC ACTIVITY S-adenosyl-L-methionine + adenine in DNA = S- adenosyl-L-homocysteine + N-6-methyladenine in DNA. {ECO:0000269|PubMed 17400740}. # DISRUPTION PHENOTYPE Mutants are viable and show no significant growth deficiency and no alteration of cell morphology. {ECO:0000269|PubMed 17400740}. # EcoGene EG11498 yhdJ # FUNCTION YHDJ_ECOLI Methylates the second adenine of the NsiI recognition sequence (5'-ATGCAT-3'). {ECO 0000269|PubMed 17400740}. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_function GO:0008170 N-methyltransferase activity; IEA:InterPro. # GO_function GO:0009007 site-specific DNA-methyltransferase (adenine-specific) activity; IDA:EcoCyc. # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0008168 methyltransferase activity # Gene3D 3.40.50.150 -; 1. # IntAct P28638 34 # InterPro IPR001091 RM_Methylase # InterPro IPR002052 DNA_methylase_N6_adenine_CS # InterPro IPR002941 DNA_methylase_N4/N6 # InterPro IPR029063 SAM-dependent_MTases # KEGG_Brite ko01000 Enzymes # Organism YHDJ_ECOLI Escherichia coli (strain K12) # PATRIC 32121954 VBIEscCol129921_3361 # PIR H65118 H65118 # PRINTS PR00508 S21N4MTFRASE # PROSITE PS00092 N6_MTASE # Pfam PF01555 N6_N4_Mtase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # REBASE 3885 M.EcoKII # RecName YHDJ_ECOLI DNA adenine methyltransferase YhdJ # RefSeq NP_417728 NC_000913.3 # RefSeq WP_001258895 NZ_CP014272.1 # SEQUENCE CAUTION Sequence=AAA58066.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the N(4)/N(6)-methyltransferase family. {ECO 0000305}. # SUPFAM SSF53335 SSF53335 # eggNOG COG0863 LUCA # eggNOG ENOG4105CEC Bacteria BLAST swissprot:YHDJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHDJ_ECOLI BioCyc ECOL316407:JW5543-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5543-MONOMER BioCyc EcoCyc:EG11498-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11498-MONOMER BioCyc MetaCyc:EG11498-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11498-MONOMER COG COG0863 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0863 DIP DIP-12296N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12296N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.85.10.3484 http://dx.doi.org/10.1073/pnas.85.10.3484 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01854-06 http://dx.doi.org/10.1128/JB.01854-06 EC_number EC:2.1.1.72 {ECO:0000269|PubMed:17400740} http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.72 {ECO:0000269|PubMed:17400740} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J03245 http://www.ebi.ac.uk/ena/data/view/J03245 EMBL M95784 http://www.ebi.ac.uk/ena/data/view/M95784 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 2.1.1.72 {ECO:0000269|PubMed:17400740} http://enzyme.expasy.org/EC/2.1.1.72 {ECO:0000269|PubMed:17400740} EchoBASE EB1461 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1461 EcoGene EG11498 http://www.ecogene.org/geneInfo.php?eg_id=EG11498 EnsemblBacteria AAC76294 http://www.ensemblgenomes.org/id/AAC76294 EnsemblBacteria AAC76294 http://www.ensemblgenomes.org/id/AAC76294 EnsemblBacteria BAE77303 http://www.ensemblgenomes.org/id/BAE77303 EnsemblBacteria BAE77303 http://www.ensemblgenomes.org/id/BAE77303 EnsemblBacteria BAE77303 http://www.ensemblgenomes.org/id/BAE77303 EnsemblBacteria b3262 http://www.ensemblgenomes.org/id/b3262 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0008170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008170 GO_function GO:0009007 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009007 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 GeneID 947695 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947695 HOGENOM HOG000125330 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125330&db=HOGENOM6 InParanoid P28638 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P28638 IntAct P28638 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P28638* IntEnz 2.1.1.72 {ECO:0000269|PubMed:17400740} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.72 {ECO:0000269|PubMed:17400740} InterPro IPR001091 http://www.ebi.ac.uk/interpro/entry/IPR001091 InterPro IPR002052 http://www.ebi.ac.uk/interpro/entry/IPR002052 InterPro IPR002941 http://www.ebi.ac.uk/interpro/entry/IPR002941 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5543 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5543 KEGG_Gene eco:b3262 http://www.genome.jp/dbget-bin/www_bget?eco:b3262 KEGG_Orthology KO:K07319 http://www.genome.jp/dbget-bin/www_bget?KO:K07319 OMA IASAPRM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IASAPRM PRINTS PR00508 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00508 PROSITE PS00092 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00092 PSORT swissprot:YHDJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHDJ_ECOLI PSORT-B swissprot:YHDJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHDJ_ECOLI PSORT2 swissprot:YHDJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHDJ_ECOLI Pfam PF01555 http://pfam.xfam.org/family/PF01555 Phobius swissprot:YHDJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHDJ_ECOLI PhylomeDB P28638 http://phylomedb.org/?seqid=P28638 ProteinModelPortal P28638 http://www.proteinmodelportal.org/query/uniprot/P28638 PubMed 1459953 http://www.ncbi.nlm.nih.gov/pubmed/1459953 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17400740 http://www.ncbi.nlm.nih.gov/pubmed/17400740 PubMed 2835774 http://www.ncbi.nlm.nih.gov/pubmed/2835774 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 REBASE 3885 http://rebase.neb.com/rebase/enz/3885.html RefSeq NP_417728 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417728 RefSeq WP_001258895 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001258895 SMR P28638 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P28638 STRING 511145.b3262 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3262&targetmode=cogs STRING COG0863 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0863&targetmode=cogs SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 UniProtKB YHDJ_ECOLI http://www.uniprot.org/uniprot/YHDJ_ECOLI UniProtKB-AC P28638 http://www.uniprot.org/uniprot/P28638 charge swissprot:YHDJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHDJ_ECOLI eggNOG COG0863 http://eggnogapi.embl.de/nog_data/html/tree/COG0863 eggNOG ENOG4105CEC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CEC epestfind swissprot:YHDJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHDJ_ECOLI garnier swissprot:YHDJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHDJ_ECOLI helixturnhelix swissprot:YHDJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHDJ_ECOLI hmoment swissprot:YHDJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHDJ_ECOLI iep swissprot:YHDJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHDJ_ECOLI inforesidue swissprot:YHDJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHDJ_ECOLI octanol swissprot:YHDJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHDJ_ECOLI pepcoil swissprot:YHDJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHDJ_ECOLI pepdigest swissprot:YHDJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHDJ_ECOLI pepinfo swissprot:YHDJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHDJ_ECOLI pepnet swissprot:YHDJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHDJ_ECOLI pepstats swissprot:YHDJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHDJ_ECOLI pepwheel swissprot:YHDJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHDJ_ECOLI pepwindow swissprot:YHDJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHDJ_ECOLI sigcleave swissprot:YHDJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHDJ_ECOLI ## Database ID URL or Descriptions # InterPro IPR009811 DUF1380 # Organism YUBJ_ECOLI Escherichia coli (strain K12) # Pfam PF07128 DUF1380 # RecName YUBJ_ECOLI Uncharacterized protein YubJ # RefSeq NP_061437 NC_002483.1 # RefSeq WP_000271685 NZ_CP014273.1 # RefSeq YP_001294722 NC_009602.1 BLAST swissprot:YUBJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YUBJ_ECOLI DOI 10.1006/plas.1999.1390 http://dx.doi.org/10.1006/plas.1999.1390 EMBL AF106329 http://www.ebi.ac.uk/ena/data/view/AF106329 EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1263596 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263596 GeneID 5290976 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5290976 InterPro IPR009811 http://www.ebi.ac.uk/interpro/entry/IPR009811 OMA GEKYVFA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GEKYVFA PSORT swissprot:YUBJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YUBJ_ECOLI PSORT-B swissprot:YUBJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YUBJ_ECOLI PSORT2 swissprot:YUBJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YUBJ_ECOLI Pfam PF07128 http://pfam.xfam.org/family/PF07128 Phobius swissprot:YUBJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YUBJ_ECOLI ProteinModelPortal P0C243 http://www.proteinmodelportal.org/query/uniprot/P0C243 PubMed 10366527 http://www.ncbi.nlm.nih.gov/pubmed/10366527 RefSeq NP_061437 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061437 RefSeq WP_000271685 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000271685 RefSeq YP_001294722 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001294722 UniProtKB YUBJ_ECOLI http://www.uniprot.org/uniprot/YUBJ_ECOLI UniProtKB-AC P0C243 http://www.uniprot.org/uniprot/P0C243 charge swissprot:YUBJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YUBJ_ECOLI epestfind swissprot:YUBJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YUBJ_ECOLI garnier swissprot:YUBJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YUBJ_ECOLI helixturnhelix swissprot:YUBJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YUBJ_ECOLI hmoment swissprot:YUBJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YUBJ_ECOLI iep swissprot:YUBJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YUBJ_ECOLI inforesidue swissprot:YUBJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YUBJ_ECOLI octanol swissprot:YUBJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YUBJ_ECOLI pepcoil swissprot:YUBJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YUBJ_ECOLI pepdigest swissprot:YUBJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YUBJ_ECOLI pepinfo swissprot:YUBJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YUBJ_ECOLI pepnet swissprot:YUBJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YUBJ_ECOLI pepstats swissprot:YUBJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YUBJ_ECOLI pepwheel swissprot:YUBJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YUBJ_ECOLI pepwindow swissprot:YUBJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YUBJ_ECOLI sigcleave swissprot:YUBJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YUBJ_ECOLI ## Database ID URL or Descriptions # AltName FKBX_ECOLI Rotamase # BioGrid 4262915 177 # CATALYTIC ACTIVITY FKBX_ECOLI Peptidylproline (omega=180) = peptidylproline (omega=0). # EcoGene EG11080 fkpB # FUNCTION FKBX_ECOLI PPIases accelerate the folding of proteins. Substrate specificity investigated with 'Suc-Ala-Xaa-Pro-Phe-4-nitroanilide' where Xaa is the amino acid tested, was found to be Phe > Leu >> Ile > Lys = Ala > Trp > His >> Gln. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003755 peptidyl-prolyl cis-trans isomerase activity; IDA:EcoCyc. # GO_function GO:0005528 FK506 binding; IBA:GO_Central. # GO_process GO:0061077 chaperone-mediated protein folding; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0006457 protein folding # IntAct P0AEM0 30 # InterPro IPR001179 PPIase_FKBP_dom # InterPro IPR023566 PPIase_FKBP # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03110 Chaperones and folding catalysts # MASS SPECTROMETRY Mass=15946; Method=Electrospray; Range=2-149; Evidence={ECO:0000269|PubMed 9188461}; # Organism FKBX_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10516 PTHR10516; 2 # PATRIC 32115147 VBIEscCol129921_0025 # PDB 2M2A NMR; -; A=1-148 # PDB 4DT4 X-ray; 1.35 A; A=1-149 # PIR JE0402 JE0402 # PROSITE PS50059 FKBP_PPIASE # Pfam PF00254 FKBP_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FKBX_ECOLI FKBP-type 16 kDa peptidyl-prolyl cis-trans isomerase # RefSeq NP_414569 NC_000913.3 # RefSeq WP_000004655 NZ_LN832404.1 # SIMILARITY Belongs to the FKBP-type PPIase family. {ECO 0000305}. # SIMILARITY Contains 1 PPIase FKBP-type domain. {ECO:0000255|PROSITE-ProRule PRU00277}. # eggNOG COG1047 LUCA # eggNOG ENOG41090X3 Bacteria BLAST swissprot:FKBX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FKBX_ECOLI BioCyc ECOL316407:JW0026-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0026-MONOMER BioCyc EcoCyc:EG11080-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11080-MONOMER BioCyc MetaCyc:EG11080-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11080-MONOMER COG COG1047 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1047 DIP DIP-35792N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35792N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.272.25.15697 http://dx.doi.org/10.1074/jbc.272.25.15697 DOI 10.1093/nar/19.1.180 http://dx.doi.org/10.1093/nar/19.1.180 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.2.1.8 http://www.genome.jp/dbget-bin/www_bget?EC:5.2.1.8 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X54945 http://www.ebi.ac.uk/ena/data/view/X54945 ENZYME 5.2.1.8 http://enzyme.expasy.org/EC/5.2.1.8 EchoBASE EB1072 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1072 EcoGene EG11080 http://www.ecogene.org/geneInfo.php?eg_id=EG11080 EnsemblBacteria AAC73139 http://www.ensemblgenomes.org/id/AAC73139 EnsemblBacteria AAC73139 http://www.ensemblgenomes.org/id/AAC73139 EnsemblBacteria BAB96597 http://www.ensemblgenomes.org/id/BAB96597 EnsemblBacteria BAB96597 http://www.ensemblgenomes.org/id/BAB96597 EnsemblBacteria BAB96597 http://www.ensemblgenomes.org/id/BAB96597 EnsemblBacteria b0028 http://www.ensemblgenomes.org/id/b0028 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003755 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003755 GO_function GO:0005528 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005528 GO_process GO:0061077 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061077 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GeneID 944807 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944807 HOGENOM HOG000154890 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000154890&db=HOGENOM6 InParanoid P0AEM0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEM0 IntAct P0AEM0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEM0* IntEnz 5.2.1.8 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.2.1.8 InterPro IPR001179 http://www.ebi.ac.uk/interpro/entry/IPR001179 InterPro IPR023566 http://www.ebi.ac.uk/interpro/entry/IPR023566 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW0026 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0026 KEGG_Gene eco:b0028 http://www.genome.jp/dbget-bin/www_bget?eco:b0028 KEGG_Orthology KO:K03774 http://www.genome.jp/dbget-bin/www_bget?KO:K03774 OMA TLHFALR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TLHFALR PANTHER PTHR10516 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10516 PDB 2M2A http://www.ebi.ac.uk/pdbe-srv/view/entry/2M2A PDB 4DT4 http://www.ebi.ac.uk/pdbe-srv/view/entry/4DT4 PDBsum 2M2A http://www.ebi.ac.uk/pdbsum/2M2A PDBsum 4DT4 http://www.ebi.ac.uk/pdbsum/4DT4 PROSITE PS50059 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50059 PSORT swissprot:FKBX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FKBX_ECOLI PSORT-B swissprot:FKBX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FKBX_ECOLI PSORT2 swissprot:FKBX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FKBX_ECOLI Pfam PF00254 http://pfam.xfam.org/family/PF00254 Phobius swissprot:FKBX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FKBX_ECOLI PhylomeDB P0AEM0 http://phylomedb.org/?seqid=P0AEM0 ProteinModelPortal P0AEM0 http://www.proteinmodelportal.org/query/uniprot/P0AEM0 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2011499 http://www.ncbi.nlm.nih.gov/pubmed/2011499 PubMed 9188461 http://www.ncbi.nlm.nih.gov/pubmed/9188461 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414569 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414569 RefSeq WP_000004655 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000004655 SMR P0AEM0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEM0 STRING 511145.b0028 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0028&targetmode=cogs STRING COG1047 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1047&targetmode=cogs UniProtKB FKBX_ECOLI http://www.uniprot.org/uniprot/FKBX_ECOLI UniProtKB-AC P0AEM0 http://www.uniprot.org/uniprot/P0AEM0 charge swissprot:FKBX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FKBX_ECOLI eggNOG COG1047 http://eggnogapi.embl.de/nog_data/html/tree/COG1047 eggNOG ENOG41090X3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41090X3 epestfind swissprot:FKBX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FKBX_ECOLI garnier swissprot:FKBX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FKBX_ECOLI helixturnhelix swissprot:FKBX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FKBX_ECOLI hmoment swissprot:FKBX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FKBX_ECOLI iep swissprot:FKBX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FKBX_ECOLI inforesidue swissprot:FKBX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FKBX_ECOLI octanol swissprot:FKBX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FKBX_ECOLI pepcoil swissprot:FKBX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FKBX_ECOLI pepdigest swissprot:FKBX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FKBX_ECOLI pepinfo swissprot:FKBX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FKBX_ECOLI pepnet swissprot:FKBX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FKBX_ECOLI pepstats swissprot:FKBX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FKBX_ECOLI pepwheel swissprot:FKBX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FKBX_ECOLI pepwindow swissprot:FKBX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FKBX_ECOLI sigcleave swissprot:FKBX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FKBX_ECOLI ## Database ID URL or Descriptions # BioGrid 4259165 20 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG13390 yeeW # INTERACTION YEEW_ECOLI P28630 holA; NbExp=2; IntAct=EBI-9146863, EBI-549153; # IntAct P64526 5 # Organism YEEW_ECOLI Escherichia coli (strain K12) # PATRIC 48663353 VBIEscCol107702_2024 # PIR E64965 E64965 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEEW_ECOLI Putative uncharacterized protein YeeW # RefSeq WP_000988600 NZ_LN832404.1 BLAST swissprot:YEEW_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEEW_ECOLI BioCyc ECOL316407:JW1988-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1988-MONOMER BioCyc EcoCyc:G7086-MONOMER http://biocyc.org/getid?id=EcoCyc:G7086-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3171 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3171 EcoGene EG13390 http://www.ecogene.org/geneInfo.php?eg_id=EG13390 EnsemblBacteria BAE76566 http://www.ensemblgenomes.org/id/BAE76566 EnsemblBacteria BAE76566 http://www.ensemblgenomes.org/id/BAE76566 EnsemblBacteria BAE76566 http://www.ensemblgenomes.org/id/BAE76566 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv IntAct P64526 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P64526* KEGG_Gene ecj:JW1988 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1988 PSORT swissprot:YEEW_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEEW_ECOLI PSORT-B swissprot:YEEW_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEEW_ECOLI PSORT2 swissprot:YEEW_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEEW_ECOLI Phobius swissprot:YEEW_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEEW_ECOLI ProteinModelPortal P64526 http://www.proteinmodelportal.org/query/uniprot/P64526 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000988600 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000988600 STRING 316407.85675187 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85675187&targetmode=cogs UniProtKB YEEW_ECOLI http://www.uniprot.org/uniprot/YEEW_ECOLI UniProtKB-AC P64526 http://www.uniprot.org/uniprot/P64526 charge swissprot:YEEW_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEEW_ECOLI epestfind swissprot:YEEW_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEEW_ECOLI garnier swissprot:YEEW_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEEW_ECOLI helixturnhelix swissprot:YEEW_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEEW_ECOLI hmoment swissprot:YEEW_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEEW_ECOLI iep swissprot:YEEW_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEEW_ECOLI inforesidue swissprot:YEEW_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEEW_ECOLI octanol swissprot:YEEW_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEEW_ECOLI pepcoil swissprot:YEEW_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEEW_ECOLI pepdigest swissprot:YEEW_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEEW_ECOLI pepinfo swissprot:YEEW_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEEW_ECOLI pepnet swissprot:YEEW_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEEW_ECOLI pepstats swissprot:YEEW_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEEW_ECOLI pepwheel swissprot:YEEW_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEEW_ECOLI pepwindow swissprot:YEEW_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEEW_ECOLI sigcleave swissprot:YEEW_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEEW_ECOLI ## Database ID URL or Descriptions # AltName NUDB_ECOLI Dihydroneopterin triphosphate pyrophosphatase # AltName NUDB_ECOLI dATP pyrophosphohydrolase # BIOPHYSICOCHEMICAL PROPERTIES NUDB_ECOLI Kinetic parameters KM=0.27 mM for dihydroneopterin triphosphate {ECO 0000269|PubMed 17698004, ECO 0000269|PubMed 8798731}; KM=0.79 mM for dATP {ECO 0000269|PubMed 17698004, ECO 0000269|PubMed 8798731}; pH dependence Optimum pH is 8.5-9. {ECO 0000269|PubMed 17698004, ECO 0000269|PubMed 8798731}; # BRENDA 3.6.1.B15 2026 # BioGrid 4260348 315 # CATALYTIC ACTIVITY 7,8-dihydroneopterin 3'-triphosphate + H(2)O = 7,8-dihydroneopterin 3'-phosphate + diphosphate. {ECO:0000269|PubMed 8798731}. # COFACTOR NUDB_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 8798731}; Note=Binds 1 Mg(2+) ion per subunit. {ECO 0000269|PubMed 8798731}; # ENZYME REGULATION Subject to product inhibition by pyrophosphate. {ECO:0000269|PubMed 8798731}. # EcoGene EG11138 nudB # FUNCTION NUDB_ECOLI Catalyzes the hydrolysis of dihydroneopterin triphosphate to dihydroneopterin monophosphate and pyrophosphate. Required for efficient folate biosynthesis. Can also hydrolyze nucleoside triphosphates with a preference for dATP. {ECO 0000269|PubMed 17698004, ECO 0000269|PubMed 8798731}. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0008828 dATP pyrophosphohydrolase activity; IDA:EcoCyc. # GO_function GO:0019177 dihydroneopterin triphosphate pyrophosphohydrolase activity; IDA:EcoCyc. # GO_process GO:0046654 tetrahydrofolate biosynthetic process; IMP:EcoCyc. # GO_process GO:0046656 folic acid biosynthetic process; IMP:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.90.79.10 -; 1. # IntAct P0AFC0 7 # InterPro IPR000086 NUDIX_hydrolase_dom # InterPro IPR003564 DHNTPase # InterPro IPR015797 NUDIX_hydrolase_dom-like # InterPro IPR020084 NUDIX_hydrolase_CS # KEGG_Brite ko01000 Enzymes # Organism NUDB_ECOLI Escherichia coli (strain K12) # PATRIC 32119053 VBIEscCol129921_1944 # PDB 2O1C X-ray; 1.80 A; A/B/C/D=1-150 # PDB 2O5W X-ray; 2.60 A; A/B/C/D=1-150 # PIR B38113 B38113 # PRINTS PR01404 NPPPHYDRLASE # PROSITE PS00893 NUDIX_BOX # PROSITE PS51462 NUDIX # Pfam PF00293 NUDIX # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NUDB_ECOLI Dihydroneopterin triphosphate diphosphatase # RefSeq NP_416379 NC_000913.3 # SIMILARITY Belongs to the Nudix hydrolase family. {ECO 0000305}. # SIMILARITY Contains 1 nudix hydrolase domain. {ECO:0000255|PROSITE-ProRule PRU00794}. # SUPFAM SSF55811 SSF55811 # eggNOG COG0494 LUCA # eggNOG ENOG4108TIT Bacteria BLAST swissprot:NUDB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NUDB_ECOLI BioCyc ECOL316407:JW1854-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1854-MONOMER BioCyc EcoCyc:H2NEOPTERINP3PYROPHOSPHOHYDRO-MONOMER http://biocyc.org/getid?id=EcoCyc:H2NEOPTERINP3PYROPHOSPHOHYDRO-MONOMER BioCyc MetaCyc:H2NEOPTERINP3PYROPHOSPHOHYDRO-MONOMER http://biocyc.org/getid?id=MetaCyc:H2NEOPTERINP3PYROPHOSPHOHYDRO-MONOMER COG COG0494 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0494 DIP DIP-10372N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10372N DOI 10.1016/j.str.2007.06.018 http://dx.doi.org/10.1016/j.str.2007.06.018 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.271.40.24649 http://dx.doi.org/10.1074/jbc.271.40.24649 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.1.67 {ECO:0000269|PubMed:8798731} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.1.67 {ECO:0000269|PubMed:8798731} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D10165 http://www.ebi.ac.uk/ena/data/view/D10165 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X59551 http://www.ebi.ac.uk/ena/data/view/X59551 ENZYME 3.6.1.67 {ECO:0000269|PubMed:8798731} http://enzyme.expasy.org/EC/3.6.1.67 {ECO:0000269|PubMed:8798731} EchoBASE EB1128 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1128 EcoGene EG11138 http://www.ecogene.org/geneInfo.php?eg_id=EG11138 EnsemblBacteria AAC74935 http://www.ensemblgenomes.org/id/AAC74935 EnsemblBacteria AAC74935 http://www.ensemblgenomes.org/id/AAC74935 EnsemblBacteria BAA15676 http://www.ensemblgenomes.org/id/BAA15676 EnsemblBacteria BAA15676 http://www.ensemblgenomes.org/id/BAA15676 EnsemblBacteria BAA15676 http://www.ensemblgenomes.org/id/BAA15676 EnsemblBacteria b1865 http://www.ensemblgenomes.org/id/b1865 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0008828 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008828 GO_function GO:0019177 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019177 GO_process GO:0046654 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046654 GO_process GO:0046656 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046656 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.90.79.10 http://www.cathdb.info/version/latest/superfamily/3.90.79.10 GeneID 946383 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946383 HOGENOM HOG000264405 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000264405&db=HOGENOM6 InParanoid P0AFC0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFC0 IntAct P0AFC0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFC0* IntEnz 3.6.1.67 {ECO:0000269|PubMed:8798731} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.1.67 {ECO:0000269|PubMed:8798731} InterPro IPR000086 http://www.ebi.ac.uk/interpro/entry/IPR000086 InterPro IPR003564 http://www.ebi.ac.uk/interpro/entry/IPR003564 InterPro IPR015797 http://www.ebi.ac.uk/interpro/entry/IPR015797 InterPro IPR020084 http://www.ebi.ac.uk/interpro/entry/IPR020084 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1854 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1854 KEGG_Gene eco:b1865 http://www.genome.jp/dbget-bin/www_bget?eco:b1865 KEGG_Orthology KO:K08310 http://www.genome.jp/dbget-bin/www_bget?KO:K08310 OMA VTRNTEH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VTRNTEH PDB 2O1C http://www.ebi.ac.uk/pdbe-srv/view/entry/2O1C PDB 2O5W http://www.ebi.ac.uk/pdbe-srv/view/entry/2O5W PDBsum 2O1C http://www.ebi.ac.uk/pdbsum/2O1C PDBsum 2O5W http://www.ebi.ac.uk/pdbsum/2O5W PRINTS PR01404 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01404 PROSITE PS00893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00893 PROSITE PS51462 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51462 PSORT swissprot:NUDB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NUDB_ECOLI PSORT-B swissprot:NUDB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NUDB_ECOLI PSORT2 swissprot:NUDB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NUDB_ECOLI Pfam PF00293 http://pfam.xfam.org/family/PF00293 Phobius swissprot:NUDB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NUDB_ECOLI ProteinModelPortal P0AFC0 http://www.proteinmodelportal.org/query/uniprot/P0AFC0 PubMed 1657895 http://www.ncbi.nlm.nih.gov/pubmed/1657895 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17698004 http://www.ncbi.nlm.nih.gov/pubmed/17698004 PubMed 1885548 http://www.ncbi.nlm.nih.gov/pubmed/1885548 PubMed 8163538 http://www.ncbi.nlm.nih.gov/pubmed/8163538 PubMed 8798731 http://www.ncbi.nlm.nih.gov/pubmed/8798731 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416379 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416379 SMR P0AFC0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFC0 STRING 511145.b1865 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1865&targetmode=cogs STRING COG0494 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0494&targetmode=cogs SUPFAM SSF55811 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55811 UniProtKB NUDB_ECOLI http://www.uniprot.org/uniprot/NUDB_ECOLI UniProtKB-AC P0AFC0 http://www.uniprot.org/uniprot/P0AFC0 charge swissprot:NUDB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NUDB_ECOLI eggNOG COG0494 http://eggnogapi.embl.de/nog_data/html/tree/COG0494 eggNOG ENOG4108TIT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108TIT epestfind swissprot:NUDB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NUDB_ECOLI garnier swissprot:NUDB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NUDB_ECOLI helixturnhelix swissprot:NUDB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NUDB_ECOLI hmoment swissprot:NUDB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NUDB_ECOLI iep swissprot:NUDB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NUDB_ECOLI inforesidue swissprot:NUDB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NUDB_ECOLI octanol swissprot:NUDB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NUDB_ECOLI pepcoil swissprot:NUDB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NUDB_ECOLI pepdigest swissprot:NUDB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NUDB_ECOLI pepinfo swissprot:NUDB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NUDB_ECOLI pepnet swissprot:NUDB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NUDB_ECOLI pepstats swissprot:NUDB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NUDB_ECOLI pepwheel swissprot:NUDB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NUDB_ECOLI pepwindow swissprot:NUDB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NUDB_ECOLI sigcleave swissprot:NUDB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NUDB_ECOLI ## Database ID URL or Descriptions # AltName RBFA_ECOLI Protein P15B # BioGrid 4262435 56 # DISRUPTION PHENOTYPE Unable to grow at 25 degrees Celsius; has decreased amounts of 70S ribosomes and increased amounts of 30s and 50S subunits. Both phenotypes are partially suppressed by overexpression of Era and completely suppressed by overexpression of Era-delta 'Ala-40-Gly-49' mutation. {ECO:0000269|PubMed 12753192}. # EcoGene EG11178 rbfA # FUNCTION RBFA_ECOLI Essential for efficient processing of 16S rRNA. Probably part of the 30S subunit prior to or during the final step in the processing of 16S free 30S ribosomal subunits. Could be some accessory protein needed for efficient assembly of the 30S subunit. May interact with the 5'-terminal helix region of 16S rRNA. Has affinity for free ribosomal 30S subunits but not for 70S ribosomes. Overexpression suppresses a cold-sensitive C23U 16S rRNA mutation and rimM deletion mutants. Its function probably overlaps Era. {ECO 0000269|PubMed 16825789, ECO 0000269|PubMed 9422595}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0043024 ribosomal small subunit binding; IDA:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IMP:EcoCyc. # GO_process GO:0009409 response to cold; IMP:EcoCyc. # GO_process GO:0030490 maturation of SSU-rRNA; IMP:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006950 response to stress # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.30.300.20 -; 1. # HAMAP MF_00003 RbfA # IntAct P0A7G2 2 # InterPro IPR000238 Ribosome-bd_facA # InterPro IPR015946 KH_dom-like_a/b # InterPro IPR020053 Ribosome-bd_factorA_CS # InterPro IPR023799 Ribosome-bd_facA_dom # KEGG_Brite ko03009 Ribosome biogenesis # Organism RBFA_ECOLI Escherichia coli (strain K12) # PATRIC 32121752 VBIEscCol129921_3262 # PDB 1KKG NMR; -; A=1-108 # PIR S01915 Q9EC15 # PROSITE PS01319 RBFA # Pfam PF02033 RBFA # ProDom PD007327 Rib_bd_factA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Ribosome-binding factor A {ECO:0000255|HAMAP-Rule MF_00003} # RefSeq NP_417636 NC_000913.3 # RefSeq WP_001040205 NZ_LN832404.1 # SIMILARITY Belongs to the RbfA family. {ECO:0000255|HAMAP- Rule MF_00003}. # SUBCELLULAR LOCATION RBFA_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00003}. # SUPFAM SSF89919 SSF89919 # TIGRFAMs TIGR00082 rbfA # eggNOG COG0858 LUCA # eggNOG ENOG4105KG7 Bacteria BLAST swissprot:RBFA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RBFA_ECOLI BioCyc ECOL316407:JW3136-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3136-MONOMER BioCyc EcoCyc:EG11178-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11178-MONOMER COG COG0858 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0858 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2003.03475.x http://dx.doi.org/10.1046/j.1365-2958.2003.03475.x DOI 10.1093/nar/16.22.10803 http://dx.doi.org/10.1093/nar/16.22.10803 DOI 10.1101/gad.9.5.626 http://dx.doi.org/10.1101/gad.9.5.626 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1159/000092818 http://dx.doi.org/10.1159/000092818 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X13270 http://www.ebi.ac.uk/ena/data/view/X13270 EMBL X13775 http://www.ebi.ac.uk/ena/data/view/X13775 EchoBASE EB1165 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1165 EcoGene EG11178 http://www.ecogene.org/geneInfo.php?eg_id=EG11178 EnsemblBacteria AAC76201 http://www.ensemblgenomes.org/id/AAC76201 EnsemblBacteria AAC76201 http://www.ensemblgenomes.org/id/AAC76201 EnsemblBacteria BAE77213 http://www.ensemblgenomes.org/id/BAE77213 EnsemblBacteria BAE77213 http://www.ensemblgenomes.org/id/BAE77213 EnsemblBacteria BAE77213 http://www.ensemblgenomes.org/id/BAE77213 EnsemblBacteria b3167 http://www.ensemblgenomes.org/id/b3167 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0043024 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043024 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0009409 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009409 GO_process GO:0030490 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030490 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.30.300.20 http://www.cathdb.info/version/latest/superfamily/3.30.300.20 GeneID 947685 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947685 HAMAP MF_00003 http://hamap.expasy.org/unirule/MF_00003 HOGENOM HOG000218325 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218325&db=HOGENOM6 InParanoid P0A7G2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7G2 IntAct P0A7G2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7G2* InterPro IPR000238 http://www.ebi.ac.uk/interpro/entry/IPR000238 InterPro IPR015946 http://www.ebi.ac.uk/interpro/entry/IPR015946 InterPro IPR020053 http://www.ebi.ac.uk/interpro/entry/IPR020053 InterPro IPR023799 http://www.ebi.ac.uk/interpro/entry/IPR023799 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW3136 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3136 KEGG_Gene eco:b3167 http://www.genome.jp/dbget-bin/www_bget?eco:b3167 KEGG_Orthology KO:K02834 http://www.genome.jp/dbget-bin/www_bget?KO:K02834 MINT MINT-1265558 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1265558 OMA VMPEIRF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VMPEIRF PDB 1KKG http://www.ebi.ac.uk/pdbe-srv/view/entry/1KKG PDBsum 1KKG http://www.ebi.ac.uk/pdbsum/1KKG PROSITE PS01319 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01319 PSORT swissprot:RBFA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RBFA_ECOLI PSORT-B swissprot:RBFA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RBFA_ECOLI PSORT2 swissprot:RBFA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RBFA_ECOLI Pfam PF02033 http://pfam.xfam.org/family/PF02033 Phobius swissprot:RBFA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RBFA_ECOLI PhylomeDB P0A7G2 http://phylomedb.org/?seqid=P0A7G2 ProteinModelPortal P0A7G2 http://www.proteinmodelportal.org/query/uniprot/P0A7G2 PubMed 12753192 http://www.ncbi.nlm.nih.gov/pubmed/12753192 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16825789 http://www.ncbi.nlm.nih.gov/pubmed/16825789 PubMed 2849753 http://www.ncbi.nlm.nih.gov/pubmed/2849753 PubMed 7535280 http://www.ncbi.nlm.nih.gov/pubmed/7535280 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9422595 http://www.ncbi.nlm.nih.gov/pubmed/9422595 RefSeq NP_417636 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417636 RefSeq WP_001040205 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001040205 SMR P0A7G2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7G2 STRING 511145.b3167 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3167&targetmode=cogs STRING COG0858 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0858&targetmode=cogs SUPFAM SSF89919 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF89919 SWISS-2DPAGE P0A7G2 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A7G2 TIGRFAMs TIGR00082 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00082 UniProtKB RBFA_ECOLI http://www.uniprot.org/uniprot/RBFA_ECOLI UniProtKB-AC P0A7G2 http://www.uniprot.org/uniprot/P0A7G2 charge swissprot:RBFA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RBFA_ECOLI eggNOG COG0858 http://eggnogapi.embl.de/nog_data/html/tree/COG0858 eggNOG ENOG4105KG7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KG7 epestfind swissprot:RBFA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RBFA_ECOLI garnier swissprot:RBFA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RBFA_ECOLI helixturnhelix swissprot:RBFA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RBFA_ECOLI hmoment swissprot:RBFA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RBFA_ECOLI iep swissprot:RBFA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RBFA_ECOLI inforesidue swissprot:RBFA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RBFA_ECOLI octanol swissprot:RBFA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RBFA_ECOLI pepcoil swissprot:RBFA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RBFA_ECOLI pepdigest swissprot:RBFA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RBFA_ECOLI pepinfo swissprot:RBFA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RBFA_ECOLI pepnet swissprot:RBFA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RBFA_ECOLI pepstats swissprot:RBFA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RBFA_ECOLI pepwheel swissprot:RBFA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RBFA_ECOLI pepwindow swissprot:RBFA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RBFA_ECOLI sigcleave swissprot:RBFA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RBFA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260448 11 # CAUTION YEHX_ECOLI Was originally thought to be part of an osmoprotectant uptake system (PubMed 15251200). However, it was shown later that the complex does not mediate osmotic stress protection (PubMed 26325238). {ECO 0000305|PubMed 15251200, ECO 0000305|PubMed 26325238}. # EcoGene EG12010 yehX # FUNCTION YEHX_ECOLI Part of an ABC transporter complex involved in low- affinity glycine betaine uptake. Probably responsible for energy coupling to the transport system. {ECO 0000269|PubMed 26325238}. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016887 ATPase activity; IEA:InterPro. # GO_process GO:0006865 amino acid transport; IEA:UniProtKB-KW. # GO_process GO:0031460 glycine betaine transport; IDA:EcoCyc. # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # Gene3D 3.40.50.300 -; 1. # INDUCTION Expression is sigma S-dependent. Induced by both osmotic shock and entry into stationary phase. {ECO:0000269|PubMed 15251200}. # IntAct P33360 8 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00209 Osmoprotectant transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism YEHX_ECOLI Escherichia coli (strain K12) # PATRIC 32119597 VBIEscCol129921_2209 # PIR H64980 H64980 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # Pfam PF00005 ABC_tran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Glycine betaine uptake system ATP-binding protein YehX {ECO 0000305} # RefSeq NP_416633 NC_000913.3 # RefSeq WP_000569315 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA # SUBUNIT The complex is composed of two ATP-binding proteins (YehX), two transmembrane proteins (YehW and YehY) and a solute- binding protein (YehZ). {ECO 0000305}. # SUPFAM SSF52540 SSF52540 # TCDB 3.A.1.12.15 the atp-binding cassette (abc) superfamily # eggNOG COG1125 LUCA # eggNOG ENOG4108IJ8 Bacteria BLAST swissprot:YEHX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEHX_ECOLI BioCyc ECOL316407:JW2117-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2117-MONOMER BioCyc EcoCyc:YEHX-MONOMER http://biocyc.org/getid?id=EcoCyc:YEHX-MONOMER BioCyc MetaCyc:YEHX-MONOMER http://biocyc.org/getid?id=MetaCyc:YEHX-MONOMER COG COG1125 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1125 DIP DIP-11912N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11912N DOI 10.1016/j.femsle.2004.05.046 http://dx.doi.org/10.1016/j.femsle.2004.05.046 DOI 10.1021/acs.biochem.5b00274 http://dx.doi.org/10.1021/acs.biochem.5b00274 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.3.- {ECO:0000305} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.- {ECO:0000305} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00007 http://www.ebi.ac.uk/ena/data/view/U00007 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.6.3.- {ECO:0000305} http://enzyme.expasy.org/EC/3.6.3.- {ECO:0000305} EchoBASE EB1948 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1948 EcoGene EG12010 http://www.ecogene.org/geneInfo.php?eg_id=EG12010 EnsemblBacteria AAC75190 http://www.ensemblgenomes.org/id/AAC75190 EnsemblBacteria AAC75190 http://www.ensemblgenomes.org/id/AAC75190 EnsemblBacteria BAE76606 http://www.ensemblgenomes.org/id/BAE76606 EnsemblBacteria BAE76606 http://www.ensemblgenomes.org/id/BAE76606 EnsemblBacteria BAE76606 http://www.ensemblgenomes.org/id/BAE76606 EnsemblBacteria b2129 http://www.ensemblgenomes.org/id/b2129 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_process GO:0006865 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865 GO_process GO:0031460 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031460 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 946659 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946659 InParanoid P33360 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33360 IntAct P33360 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33360* IntEnz 3.6.3.- {ECO:0000305} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.- {ECO:0000305} InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2117 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2117 KEGG_Gene eco:b2129 http://www.genome.jp/dbget-bin/www_bget?eco:b2129 KEGG_Orthology KO:K05847 http://www.genome.jp/dbget-bin/www_bget?KO:K05847 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 MINT MINT-1228275 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1228275 OMA KWPRARI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KWPRARI PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:YEHX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEHX_ECOLI PSORT-B swissprot:YEHX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEHX_ECOLI PSORT2 swissprot:YEHX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEHX_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Phobius swissprot:YEHX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEHX_ECOLI PhylomeDB P33360 http://phylomedb.org/?seqid=P33360 ProteinModelPortal P33360 http://www.proteinmodelportal.org/query/uniprot/P33360 PubMed 15251200 http://www.ncbi.nlm.nih.gov/pubmed/15251200 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 26325238 http://www.ncbi.nlm.nih.gov/pubmed/26325238 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416633 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416633 RefSeq WP_000569315 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000569315 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P33360 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33360 STRING 511145.b2129 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2129&targetmode=cogs STRING COG1125 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1125&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.12.15 http://www.tcdb.org/search/result.php?tc=3.A.1.12.15 UniProtKB YEHX_ECOLI http://www.uniprot.org/uniprot/YEHX_ECOLI UniProtKB-AC P33360 http://www.uniprot.org/uniprot/P33360 charge swissprot:YEHX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEHX_ECOLI eggNOG COG1125 http://eggnogapi.embl.de/nog_data/html/tree/COG1125 eggNOG ENOG4108IJ8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108IJ8 epestfind swissprot:YEHX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEHX_ECOLI garnier swissprot:YEHX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEHX_ECOLI helixturnhelix swissprot:YEHX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEHX_ECOLI hmoment swissprot:YEHX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEHX_ECOLI iep swissprot:YEHX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEHX_ECOLI inforesidue swissprot:YEHX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEHX_ECOLI octanol swissprot:YEHX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEHX_ECOLI pepcoil swissprot:YEHX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEHX_ECOLI pepdigest swissprot:YEHX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEHX_ECOLI pepinfo swissprot:YEHX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEHX_ECOLI pepnet swissprot:YEHX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEHX_ECOLI pepstats swissprot:YEHX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEHX_ECOLI pepwheel swissprot:YEHX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEHX_ECOLI pepwindow swissprot:YEHX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEHX_ECOLI sigcleave swissprot:YEHX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEHX_ECOLI ## Database ID URL or Descriptions # BioGrid 4262899 10 # CATALYTIC ACTIVITY ADHP_ECOLI An alcohol + NAD(+) = an aldehyde or ketone + NADH. # COFACTOR ADHP_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000250}; Note=Binds 2 Zn(2+) ions per subunit. {ECO 0000250}; # EcoGene EG12622 adhP # FUNCTION ADHP_ECOLI Preferred specificity is towards 1-propanol. # GO_function GO:0004022 alcohol dehydrogenase (NAD) activity; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0045471 response to ethanol; IEP:EcoliWiki. # GO_process GO:0046187 acetaldehyde catabolic process; IDA:EcoliWiki. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # Gene3D 3.40.50.720 -; 1. # Gene3D 3.90.180.10 -; 1. # IntAct P39451 5 # InterPro IPR002085 ADH_SF_Zn-type # InterPro IPR002328 ADH_Zn_CS # InterPro IPR011032 GroES-like # InterPro IPR013149 ADH_C # InterPro IPR013154 ADH_N # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR020843 PKS_ER # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00010 Glycolysis / Gluconeogenesis # KEGG_Pathway ko00071 Fatty acid metabolism # KEGG_Pathway ko00350 Tyrosine metabolism # KEGG_Pathway ko00625 Chloroalkane and chloroalkene degradation # KEGG_Pathway ko00626 Naphthalene degradation # KEGG_Pathway ko00830 Retinol metabolism # KEGG_Pathway ko00980 Metabolism of xenobiotics by cytochrome P450 # KEGG_Pathway ko00982 Drug metabolism - cytochrome P450 # Organism ADHP_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11695 PTHR11695 # PATRIC 32118250 VBIEscCol129921_1545 # PDB 4GKV X-ray; 2.01 A; A/B/C/D=1-336 # PIR A64901 A64901 # PROSITE PS00059 ADH_ZINC # Pfam PF00107 ADH_zinc_N # Pfam PF08240 ADH_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ADHP_ECOLI Alcohol dehydrogenase, propanol-preferring # RefSeq NP_415995 NC_000913.3 # RefSeq WP_000642433 NZ_LN832404.1 # SIMILARITY Belongs to the zinc-containing alcohol dehydrogenase family. {ECO 0000305}. # SMART SM00829 PKS_ER # SUPFAM SSF50129 SSF50129 # SUPFAM SSF51735 SSF51735 # eggNOG COG1064 LUCA # eggNOG ENOG4105DQ4 Bacteria BLAST swissprot:ADHP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ADHP_ECOLI BioCyc ECOL316407:JW1474-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1474-MONOMER BioCyc EcoCyc:ADHP-MONOMER http://biocyc.org/getid?id=EcoCyc:ADHP-MONOMER BioCyc MetaCyc:ADHP-MONOMER http://biocyc.org/getid?id=MetaCyc:ADHP-MONOMER COG COG1064 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1064 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.1 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M31532 http://www.ebi.ac.uk/ena/data/view/M31532 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.1.1.1 http://enzyme.expasy.org/EC/1.1.1.1 EchoBASE EB2506 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2506 EcoGene EG12622 http://www.ecogene.org/geneInfo.php?eg_id=EG12622 EnsemblBacteria AAC74551 http://www.ensemblgenomes.org/id/AAC74551 EnsemblBacteria AAC74551 http://www.ensemblgenomes.org/id/AAC74551 EnsemblBacteria BAA15126 http://www.ensemblgenomes.org/id/BAA15126 EnsemblBacteria BAA15126 http://www.ensemblgenomes.org/id/BAA15126 EnsemblBacteria BAA15126 http://www.ensemblgenomes.org/id/BAA15126 EnsemblBacteria b1478 http://www.ensemblgenomes.org/id/b1478 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004022 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004022 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0045471 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045471 GO_process GO:0046187 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046187 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 Gene3D 3.90.180.10 http://www.cathdb.info/version/latest/superfamily/3.90.180.10 GeneID 946036 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946036 HOGENOM HOG000294685 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000294685&db=HOGENOM6 InParanoid P39451 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39451 IntAct P39451 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39451* IntEnz 1.1.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.1 InterPro IPR002085 http://www.ebi.ac.uk/interpro/entry/IPR002085 InterPro IPR002328 http://www.ebi.ac.uk/interpro/entry/IPR002328 InterPro IPR011032 http://www.ebi.ac.uk/interpro/entry/IPR011032 InterPro IPR013149 http://www.ebi.ac.uk/interpro/entry/IPR013149 InterPro IPR013154 http://www.ebi.ac.uk/interpro/entry/IPR013154 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR020843 http://www.ebi.ac.uk/interpro/entry/IPR020843 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1474 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1474 KEGG_Gene eco:b1478 http://www.genome.jp/dbget-bin/www_bget?eco:b1478 KEGG_Orthology KO:K13953 http://www.genome.jp/dbget-bin/www_bget?KO:K13953 KEGG_Pathway ko00010 http://www.genome.jp/kegg-bin/show_pathway?ko00010 KEGG_Pathway ko00071 http://www.genome.jp/kegg-bin/show_pathway?ko00071 KEGG_Pathway ko00350 http://www.genome.jp/kegg-bin/show_pathway?ko00350 KEGG_Pathway ko00625 http://www.genome.jp/kegg-bin/show_pathway?ko00625 KEGG_Pathway ko00626 http://www.genome.jp/kegg-bin/show_pathway?ko00626 KEGG_Pathway ko00830 http://www.genome.jp/kegg-bin/show_pathway?ko00830 KEGG_Pathway ko00980 http://www.genome.jp/kegg-bin/show_pathway?ko00980 KEGG_Pathway ko00982 http://www.genome.jp/kegg-bin/show_pathway?ko00982 KEGG_Reaction rn:R00623 http://www.genome.jp/dbget-bin/www_bget?rn:R00623 KEGG_Reaction rn:R00754 http://www.genome.jp/dbget-bin/www_bget?rn:R00754 KEGG_Reaction rn:R02124 http://www.genome.jp/dbget-bin/www_bget?rn:R02124 KEGG_Reaction rn:R04880 http://www.genome.jp/dbget-bin/www_bget?rn:R04880 KEGG_Reaction rn:R05233 http://www.genome.jp/dbget-bin/www_bget?rn:R05233 KEGG_Reaction rn:R05234 http://www.genome.jp/dbget-bin/www_bget?rn:R05234 KEGG_Reaction rn:R06917 http://www.genome.jp/dbget-bin/www_bget?rn:R06917 KEGG_Reaction rn:R06927 http://www.genome.jp/dbget-bin/www_bget?rn:R06927 KEGG_Reaction rn:R07105 http://www.genome.jp/dbget-bin/www_bget?rn:R07105 KEGG_Reaction rn:R08281 http://www.genome.jp/dbget-bin/www_bget?rn:R08281 KEGG_Reaction rn:R08306 http://www.genome.jp/dbget-bin/www_bget?rn:R08306 KEGG_Reaction rn:R08310 http://www.genome.jp/dbget-bin/www_bget?rn:R08310 OMA ATHCIVS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ATHCIVS PANTHER PTHR11695 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11695 PDB 4GKV http://www.ebi.ac.uk/pdbe-srv/view/entry/4GKV PDBsum 4GKV http://www.ebi.ac.uk/pdbsum/4GKV PROSITE PS00059 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00059 PSORT swissprot:ADHP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ADHP_ECOLI PSORT-B swissprot:ADHP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ADHP_ECOLI PSORT2 swissprot:ADHP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ADHP_ECOLI Pfam PF00107 http://pfam.xfam.org/family/PF00107 Pfam PF08240 http://pfam.xfam.org/family/PF08240 Phobius swissprot:ADHP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ADHP_ECOLI PhylomeDB P39451 http://phylomedb.org/?seqid=P39451 ProteinModelPortal P39451 http://www.proteinmodelportal.org/query/uniprot/P39451 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2158980 http://www.ncbi.nlm.nih.gov/pubmed/2158980 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415995 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415995 RefSeq WP_000642433 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000642433 SMART SM00829 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00829 SMR P39451 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39451 STRING 511145.b1478 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1478&targetmode=cogs STRING COG1064 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1064&targetmode=cogs SUPFAM SSF50129 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50129 SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB ADHP_ECOLI http://www.uniprot.org/uniprot/ADHP_ECOLI UniProtKB-AC P39451 http://www.uniprot.org/uniprot/P39451 charge swissprot:ADHP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ADHP_ECOLI eggNOG COG1064 http://eggnogapi.embl.de/nog_data/html/tree/COG1064 eggNOG ENOG4105DQ4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DQ4 epestfind swissprot:ADHP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ADHP_ECOLI garnier swissprot:ADHP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ADHP_ECOLI helixturnhelix swissprot:ADHP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ADHP_ECOLI hmoment swissprot:ADHP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ADHP_ECOLI iep swissprot:ADHP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ADHP_ECOLI inforesidue swissprot:ADHP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ADHP_ECOLI octanol swissprot:ADHP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ADHP_ECOLI pepcoil swissprot:ADHP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ADHP_ECOLI pepdigest swissprot:ADHP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ADHP_ECOLI pepinfo swissprot:ADHP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ADHP_ECOLI pepnet swissprot:ADHP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ADHP_ECOLI pepstats swissprot:ADHP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ADHP_ECOLI pepwheel swissprot:ADHP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ADHP_ECOLI pepwindow swissprot:ADHP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ADHP_ECOLI sigcleave swissprot:ADHP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ADHP_ECOLI ## Database ID URL or Descriptions # EcoGene EG14432 ykgO # GO_component GO:0005840 ribosome; IEA:UniProtKB-KW. # GO_function GO:0003735 structural constituent of ribosome; IEA:InterPro. # GO_process GO:0006412 translation; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005840 ribosome # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_process GO:0006412 translation # HAMAP MF_00251 Ribosomal_L36 # INDUCTION RL362_ECOLI Expressed during stationary phase in minimal glucose medium (PubMed 19121005), induced by EDTA, strongly repressed on shifting from minimal glucose to minimal glycerol medium (at protein level). Induced under zinc-limiting conditions in stationary phase; repressed by the zinc uptake regulatory protein Zur. {ECO 0000269|PubMed 19121005, ECO 0000269|PubMed 19734316}. # InterPro IPR000473 Ribosomal_L36 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # Organism RL362_ECOLI Escherichia coli (strain K12) # PANTHER PTHR18804 PTHR18804 # PATRIC 32115715 VBIEscCol129921_0300 # PROSITE PS00828 RIBOSOMAL_L36 # Pfam PF00444 Ribosomal_L36 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RL362_ECOLI 50S ribosomal protein L36 2 # RefSeq WP_000866436 NZ_LN832404.1 # RefSeq YP_588437 NC_000913.3 # SIMILARITY Belongs to the ribosomal protein L36P family. {ECO 0000305}. # SUPFAM SSF57840 SSF57840 # TIGRFAMs TIGR01022 rpmJ_bact # eggNOG COG0257 LUCA # eggNOG ENOG4105YK5 Bacteria BLAST swissprot:RL362_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RL362_ECOLI BioCyc ECOL316407:JW5034-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5034-MONOMER BioCyc EcoCyc:MONOMER0-2656 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2656 COG COG0257 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0257 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2008.06495.x http://dx.doi.org/10.1111/j.1365-2958.2008.06495.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00872-09 http://dx.doi.org/10.1128/JB.00872-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14432 http://www.ecogene.org/geneInfo.php?eg_id=EG14432 EnsemblBacteria ABD18636 http://www.ensemblgenomes.org/id/ABD18636 EnsemblBacteria ABD18636 http://www.ensemblgenomes.org/id/ABD18636 EnsemblBacteria BAE76080 http://www.ensemblgenomes.org/id/BAE76080 EnsemblBacteria BAE76080 http://www.ensemblgenomes.org/id/BAE76080 EnsemblBacteria BAE76080 http://www.ensemblgenomes.org/id/BAE76080 EnsemblBacteria b4506 http://www.ensemblgenomes.org/id/b4506 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005840 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005840 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_component GO:0005840 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005840 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GeneID 1450238 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1450238 HAMAP MF_00251 http://hamap.expasy.org/unirule/MF_00251 HOGENOM HOG000111585 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000111585&db=HOGENOM6 InParanoid Q2EEQ2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q2EEQ2 InterPro IPR000473 http://www.ebi.ac.uk/interpro/entry/IPR000473 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW5034 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5034 KEGG_Gene eco:b4506 http://www.genome.jp/dbget-bin/www_bget?eco:b4506 KEGG_Orthology KO:K02919 http://www.genome.jp/dbget-bin/www_bget?KO:K02919 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 PANTHER PTHR18804 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18804 PROSITE PS00828 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00828 PSORT swissprot:RL362_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RL362_ECOLI PSORT-B swissprot:RL362_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RL362_ECOLI PSORT2 swissprot:RL362_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RL362_ECOLI Pfam PF00444 http://pfam.xfam.org/family/PF00444 Phobius swissprot:RL362_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RL362_ECOLI ProteinModelPortal Q2EEQ2 http://www.proteinmodelportal.org/query/uniprot/Q2EEQ2 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19121005 http://www.ncbi.nlm.nih.gov/pubmed/19121005 PubMed 19734316 http://www.ncbi.nlm.nih.gov/pubmed/19734316 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000866436 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000866436 RefSeq YP_588437 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_588437 SMR Q2EEQ2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q2EEQ2 STRING 511145.b4506 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4506&targetmode=cogs STRING COG0257 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0257&targetmode=cogs SUPFAM SSF57840 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF57840 TIGRFAMs TIGR01022 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01022 UniProtKB RL362_ECOLI http://www.uniprot.org/uniprot/RL362_ECOLI UniProtKB-AC Q2EEQ2 http://www.uniprot.org/uniprot/Q2EEQ2 charge swissprot:RL362_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RL362_ECOLI eggNOG COG0257 http://eggnogapi.embl.de/nog_data/html/tree/COG0257 eggNOG ENOG4105YK5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105YK5 epestfind swissprot:RL362_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RL362_ECOLI garnier swissprot:RL362_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RL362_ECOLI helixturnhelix swissprot:RL362_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RL362_ECOLI hmoment swissprot:RL362_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RL362_ECOLI iep swissprot:RL362_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RL362_ECOLI inforesidue swissprot:RL362_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RL362_ECOLI octanol swissprot:RL362_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RL362_ECOLI pepcoil swissprot:RL362_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RL362_ECOLI pepdigest swissprot:RL362_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RL362_ECOLI pepinfo swissprot:RL362_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RL362_ECOLI pepnet swissprot:RL362_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RL362_ECOLI pepstats swissprot:RL362_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RL362_ECOLI pepwheel swissprot:RL362_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RL362_ECOLI pepwindow swissprot:RL362_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RL362_ECOLI sigcleave swissprot:RL362_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RL362_ECOLI ## Database ID URL or Descriptions # EcoGene EG14482 yobI # INDUCTION YOBI_ECOLI In stationary phase, induced at 45 degrees Celsius (at protein level). {ECO 0000269|PubMed 19121005, ECO 0000269|PubMed 19734316}. # Organism YOBI_ECOLI Escherichia coli (strain K12) # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YOBI_ECOLI Uncharacterized protein YobI # RefSeq YP_002791244 NC_000913.3 BLAST swissprot:YOBI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YOBI_ECOLI BioCyc EcoCyc:MONOMER0-2871 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2871 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2008.06495.x http://dx.doi.org/10.1111/j.1365-2958.2008.06495.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00872-09 http://dx.doi.org/10.1128/JB.00872-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14482 http://www.ecogene.org/geneInfo.php?eg_id=EG14482 EnsemblBacteria ACO59996 http://www.ensemblgenomes.org/id/ACO59996 EnsemblBacteria ACO59996 http://www.ensemblgenomes.org/id/ACO59996 EnsemblBacteria b4677 http://www.ensemblgenomes.org/id/b4677 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 7751641 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7751641 KEGG_Gene eco:b4677 http://www.genome.jp/dbget-bin/www_bget?eco:b4677 PSORT swissprot:YOBI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YOBI_ECOLI PSORT-B swissprot:YOBI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YOBI_ECOLI PSORT2 swissprot:YOBI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YOBI_ECOLI Phobius swissprot:YOBI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YOBI_ECOLI PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19121005 http://www.ncbi.nlm.nih.gov/pubmed/19121005 PubMed 19734316 http://www.ncbi.nlm.nih.gov/pubmed/19734316 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq YP_002791244 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_002791244 STRING 511145.b4677 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4677&targetmode=cogs UniProtKB YOBI_ECOLI http://www.uniprot.org/uniprot/YOBI_ECOLI UniProtKB-AC C1P604 http://www.uniprot.org/uniprot/C1P604 charge swissprot:YOBI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YOBI_ECOLI epestfind swissprot:YOBI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YOBI_ECOLI garnier swissprot:YOBI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YOBI_ECOLI helixturnhelix swissprot:YOBI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YOBI_ECOLI hmoment swissprot:YOBI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YOBI_ECOLI iep swissprot:YOBI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YOBI_ECOLI inforesidue swissprot:YOBI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YOBI_ECOLI octanol swissprot:YOBI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YOBI_ECOLI pepcoil swissprot:YOBI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YOBI_ECOLI pepdigest swissprot:YOBI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YOBI_ECOLI pepinfo swissprot:YOBI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YOBI_ECOLI pepnet swissprot:YOBI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YOBI_ECOLI pepstats swissprot:YOBI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YOBI_ECOLI pepwheel swissprot:YOBI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YOBI_ECOLI pepwindow swissprot:YOBI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YOBI_ECOLI sigcleave swissprot:YOBI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YOBI_ECOLI ## Database ID URL or Descriptions # BioGrid 4259732 5 # EcoGene EG10042 ampE # FUNCTION AMPE_ECOLI Putative signaling protein in beta-lactamase regulation. AmpE seems not to act as a direct sensor for beta-lactams. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # INDUCTION AMPE_ECOLI The level of AmpE affects the basal level of beta- lactamase expression in the absence of AmpD and in the presence of the AmpR transcriptional regulator. # IntAct P0AE14 2 # InterPro IPR031347 AmpE # Organism AMPE_ECOLI Escherichia coli (strain K12) # PATRIC 32115323 VBIEscCol129921_0113 # PIR S05570 S05570 # Pfam PF17113 AmpE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AMPE_ECOLI Protein AmpE # RefSeq NP_414653 NC_000913.3 # RefSeq WP_000172005 NZ_LN832404.1 # SUBCELLULAR LOCATION AMPE_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 9.B.125.1 the ampe/cobd (ampe/cobd) family # eggNOG COG3725 LUCA # eggNOG ENOG4106A72 Bacteria BLAST swissprot:AMPE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AMPE_ECOLI BioCyc ECOL316407:JW0107-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0107-MONOMER BioCyc EcoCyc:EG10042-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10042-MONOMER COG COG3725 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3725 DIP DIP-47964N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47964N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1989.tb00259.x http://dx.doi.org/10.1111/j.1365-2958.1989.tb00259.x DOI 10.1111/j.1365-2958.1989.tb00262.x http://dx.doi.org/10.1111/j.1365-2958.1989.tb00262.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X15237 http://www.ebi.ac.uk/ena/data/view/X15237 EchoBASE EB0040 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0040 EcoGene EG10042 http://www.ecogene.org/geneInfo.php?eg_id=EG10042 EnsemblBacteria AAC73222 http://www.ensemblgenomes.org/id/AAC73222 EnsemblBacteria AAC73222 http://www.ensemblgenomes.org/id/AAC73222 EnsemblBacteria BAB96680 http://www.ensemblgenomes.org/id/BAB96680 EnsemblBacteria BAB96680 http://www.ensemblgenomes.org/id/BAB96680 EnsemblBacteria BAB96680 http://www.ensemblgenomes.org/id/BAB96680 EnsemblBacteria b0111 http://www.ensemblgenomes.org/id/b0111 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 946678 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946678 HOGENOM HOG000116788 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000116788&db=HOGENOM6 IntAct P0AE14 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AE14* InterPro IPR031347 http://www.ebi.ac.uk/interpro/entry/IPR031347 KEGG_Gene ecj:JW0107 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0107 KEGG_Gene eco:b0111 http://www.genome.jp/dbget-bin/www_bget?eco:b0111 KEGG_Orthology KO:K03807 http://www.genome.jp/dbget-bin/www_bget?KO:K03807 OMA HFSRALP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HFSRALP PSORT swissprot:AMPE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AMPE_ECOLI PSORT-B swissprot:AMPE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AMPE_ECOLI PSORT2 swissprot:AMPE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AMPE_ECOLI Pfam PF17113 http://pfam.xfam.org/family/PF17113 Phobius swissprot:AMPE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AMPE_ECOLI ProteinModelPortal P0AE14 http://www.proteinmodelportal.org/query/uniprot/P0AE14 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2607970 http://www.ncbi.nlm.nih.gov/pubmed/2607970 PubMed 2691840 http://www.ncbi.nlm.nih.gov/pubmed/2691840 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414653 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414653 RefSeq WP_000172005 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000172005 STRING 511145.b0111 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0111&targetmode=cogs STRING COG3725 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3725&targetmode=cogs TCDB 9.B.125.1 http://www.tcdb.org/search/result.php?tc=9.B.125.1 UniProtKB AMPE_ECOLI http://www.uniprot.org/uniprot/AMPE_ECOLI UniProtKB-AC P0AE14 http://www.uniprot.org/uniprot/P0AE14 charge swissprot:AMPE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AMPE_ECOLI eggNOG COG3725 http://eggnogapi.embl.de/nog_data/html/tree/COG3725 eggNOG ENOG4106A72 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106A72 epestfind swissprot:AMPE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AMPE_ECOLI garnier swissprot:AMPE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AMPE_ECOLI helixturnhelix swissprot:AMPE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AMPE_ECOLI hmoment swissprot:AMPE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AMPE_ECOLI iep swissprot:AMPE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AMPE_ECOLI inforesidue swissprot:AMPE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AMPE_ECOLI octanol swissprot:AMPE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AMPE_ECOLI pepcoil swissprot:AMPE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AMPE_ECOLI pepdigest swissprot:AMPE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AMPE_ECOLI pepinfo swissprot:AMPE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AMPE_ECOLI pepnet swissprot:AMPE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AMPE_ECOLI pepstats swissprot:AMPE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AMPE_ECOLI pepwheel swissprot:AMPE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AMPE_ECOLI pepwindow swissprot:AMPE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AMPE_ECOLI sigcleave swissprot:AMPE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AMPE_ECOLI ## Database ID URL or Descriptions # BRENDA 2.2.1 2026 # BioGrid 4260954 9 # CATALYTIC ACTIVITY TKT1_ECOLI Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate. {ECO 0000269|PubMed 17914867, ECO 0000269|PubMed 7607225}. # COFACTOR TKT1_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 7607225}; Name=Ca(2+); Xref=ChEBI CHEBI 29108; Evidence={ECO 0000269|PubMed 7607225}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 7607225}; Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000269|PubMed 7607225}; Note=Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+). {ECO 0000269|PubMed 7607225}; # COFACTOR TKT1_ECOLI Name=thiamine diphosphate; Xref=ChEBI CHEBI 58937; Evidence={ECO 0000269|PubMed 7607225}; Note=Binds 1 thiamine pyrophosphate per subunit. During the reaction, the substrate forms a covalent intermediate with the cofactor. {ECO 0000269|PubMed 17914867}; # EcoGene EG11427 tktA # FUNCTION TKT1_ECOLI Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. Thus, catalyzes the reversible transfer of a two-carbon ketol group from sedoheptulose-7-phosphate to glyceraldehyde-3-phosphate, producing xylulose-5-phosphate and ribose-5-phosphate. {ECO 0000269|PubMed 17914867, ECO 0000269|PubMed 7607225}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004802 transketolase activity; IDA:EcoCyc. # GO_function GO:0030145 manganese ion binding; IDA:EcoCyc. # GO_function GO:0030976 thiamine pyrophosphate binding; IDA:EcoCyc. # GO_process GO:0009052 pentose-phosphate shunt, non-oxidative branch; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # Gene3D 3.40.50.920 -; 1. # Gene3D 3.40.50.970 -; 2. # InterPro IPR005474 Transketolase_N # InterPro IPR005475 Transketolase-like_Pyr-bd # InterPro IPR005478 Transketolase_bac-like # InterPro IPR009014 Transketo_C/PFOR_II # InterPro IPR020826 Transketolase_BS # InterPro IPR029061 THDP-binding # InterPro IPR033247 Transketolase_fam # InterPro IPR033248 Transketolase_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00030 Pentose phosphate pathway # KEGG_Pathway ko00710 Carbon fixation in photosynthetic organisms # KEGG_Pathway ko01051 Biosynthesis of ansamycins # Organism TKT1_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11624 PTHR11624; 2 # PATRIC 32121282 VBIEscCol129921_3029 # PDB 1QGD X-ray; 1.90 A; A/B=2-663 # PDB 2R5N X-ray; 1.60 A; A/B=1-663 # PDB 2R8O X-ray; 1.47 A; A/B=1-663 # PDB 2R8P X-ray; 1.65 A; A/B=1-663 # PIR F65078 XJECTK # PROSITE PS00801 TRANSKETOLASE_1 # PROSITE PS00802 TRANSKETOLASE_2 # Pfam PF00456 Transketolase_N # Pfam PF02779 Transket_pyr # Pfam PF02780 Transketolase_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TKT1_ECOLI Transketolase 1 # RefSeq WP_000098614 NZ_LN832404.1 # RefSeq YP_026188 NC_000913.3 # SIMILARITY Belongs to the transketolase family. {ECO 0000305}. # SMART SM00861 Transket_pyr # SUBUNIT TKT1_ECOLI Homodimer. {ECO 0000269|PubMed 17914867, ECO 0000269|PubMed 7607225, ECO 0000269|Ref.9}. # SUPFAM SSF52518 SSF52518; 2 # SUPFAM SSF52922 SSF52922 # TIGRFAMs TIGR00232 tktlase_bact # eggNOG COG0021 LUCA # eggNOG ENOG4105CV1 Bacteria BLAST swissprot:TKT1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TKT1_ECOLI BioCyc ECOL316407:JW5478-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5478-MONOMER BioCyc EcoCyc:TRANSKETOI-MONOMER http://biocyc.org/getid?id=EcoCyc:TRANSKETOI-MONOMER BioCyc MetaCyc:TRANSKETOI-MONOMER http://biocyc.org/getid?id=MetaCyc:TRANSKETOI-MONOMER COG COG0021 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0021 DIP DIP-10998N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10998N DOI 10.1016/0167-4781(93)90161-6 http://dx.doi.org/10.1016/0167-4781(93)90161-6 DOI 10.1021/bi700844m http://dx.doi.org/10.1021/bi700844m DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1111/j.1432-1033.1995.0525h.x http://dx.doi.org/10.1111/j.1432-1033.1995.0525h.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.2.1.1 {ECO:0000269|PubMed:17914867, ECO:0000269|PubMed:7607225} http://www.genome.jp/dbget-bin/www_bget?EC:2.2.1.1 {ECO:0000269|PubMed:17914867, ECO:0000269|PubMed:7607225} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M32363 http://www.ebi.ac.uk/ena/data/view/M32363 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EMBL X68025 http://www.ebi.ac.uk/ena/data/view/X68025 ENZYME 2.2.1.1 {ECO:0000269|PubMed:17914867, ECO:0000269|PubMed:7607225} http://enzyme.expasy.org/EC/2.2.1.1 {ECO:0000269|PubMed:17914867, ECO:0000269|PubMed:7607225} EchoBASE EB1397 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1397 EcoGene EG11427 http://www.ecogene.org/geneInfo.php?eg_id=EG11427 EnsemblBacteria AAT48155 http://www.ensemblgenomes.org/id/AAT48155 EnsemblBacteria AAT48155 http://www.ensemblgenomes.org/id/AAT48155 EnsemblBacteria BAE76998 http://www.ensemblgenomes.org/id/BAE76998 EnsemblBacteria BAE76998 http://www.ensemblgenomes.org/id/BAE76998 EnsemblBacteria BAE76998 http://www.ensemblgenomes.org/id/BAE76998 EnsemblBacteria b2935 http://www.ensemblgenomes.org/id/b2935 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004802 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_function GO:0030976 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030976 GO_process GO:0009052 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009052 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.50.920 http://www.cathdb.info/version/latest/superfamily/3.40.50.920 Gene3D 3.40.50.970 http://www.cathdb.info/version/latest/superfamily/3.40.50.970 GeneID 947420 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947420 HOGENOM HOG000225953 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000225953&db=HOGENOM6 InParanoid P27302 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P27302 IntAct P27302 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P27302* IntEnz 2.2.1.1 {ECO:0000269|PubMed:17914867, ECO:0000269|PubMed:7607225} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.2.1.1 {ECO:0000269|PubMed:17914867, ECO:0000269|PubMed:7607225} InterPro IPR005474 http://www.ebi.ac.uk/interpro/entry/IPR005474 InterPro IPR005475 http://www.ebi.ac.uk/interpro/entry/IPR005475 InterPro IPR005478 http://www.ebi.ac.uk/interpro/entry/IPR005478 InterPro IPR009014 http://www.ebi.ac.uk/interpro/entry/IPR009014 InterPro IPR020826 http://www.ebi.ac.uk/interpro/entry/IPR020826 InterPro IPR029061 http://www.ebi.ac.uk/interpro/entry/IPR029061 InterPro IPR033247 http://www.ebi.ac.uk/interpro/entry/IPR033247 InterPro IPR033248 http://www.ebi.ac.uk/interpro/entry/IPR033248 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5478 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5478 KEGG_Gene eco:b2935 http://www.genome.jp/dbget-bin/www_bget?eco:b2935 KEGG_Orthology KO:K00615 http://www.genome.jp/dbget-bin/www_bget?KO:K00615 KEGG_Pathway ko00030 http://www.genome.jp/kegg-bin/show_pathway?ko00030 KEGG_Pathway ko00710 http://www.genome.jp/kegg-bin/show_pathway?ko00710 KEGG_Pathway ko01051 http://www.genome.jp/kegg-bin/show_pathway?ko01051 KEGG_Reaction rn:R01067 http://www.genome.jp/dbget-bin/www_bget?rn:R01067 KEGG_Reaction rn:R01641 http://www.genome.jp/dbget-bin/www_bget?rn:R01641 KEGG_Reaction rn:R01830 http://www.genome.jp/dbget-bin/www_bget?rn:R01830 KEGG_Reaction rn:R06590 http://www.genome.jp/dbget-bin/www_bget?rn:R06590 MINT MINT-1260939 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1260939 OMA WEVLYVE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WEVLYVE PANTHER PTHR11624 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11624 PDB 1QGD http://www.ebi.ac.uk/pdbe-srv/view/entry/1QGD PDB 2R5N http://www.ebi.ac.uk/pdbe-srv/view/entry/2R5N PDB 2R8O http://www.ebi.ac.uk/pdbe-srv/view/entry/2R8O PDB 2R8P http://www.ebi.ac.uk/pdbe-srv/view/entry/2R8P PDBsum 1QGD http://www.ebi.ac.uk/pdbsum/1QGD PDBsum 2R5N http://www.ebi.ac.uk/pdbsum/2R5N PDBsum 2R8O http://www.ebi.ac.uk/pdbsum/2R8O PDBsum 2R8P http://www.ebi.ac.uk/pdbsum/2R8P PROSITE PS00801 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00801 PROSITE PS00802 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00802 PSORT swissprot:TKT1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TKT1_ECOLI PSORT-B swissprot:TKT1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TKT1_ECOLI PSORT2 swissprot:TKT1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TKT1_ECOLI Pfam PF00456 http://pfam.xfam.org/family/PF00456 Pfam PF02779 http://pfam.xfam.org/family/PF02779 Pfam PF02780 http://pfam.xfam.org/family/PF02780 Phobius swissprot:TKT1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TKT1_ECOLI PhylomeDB P27302 http://phylomedb.org/?seqid=P27302 ProteinModelPortal P27302 http://www.proteinmodelportal.org/query/uniprot/P27302 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17914867 http://www.ncbi.nlm.nih.gov/pubmed/17914867 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 2153656 http://www.ncbi.nlm.nih.gov/pubmed/2153656 PubMed 7607225 http://www.ncbi.nlm.nih.gov/pubmed/7607225 PubMed 8241274 http://www.ncbi.nlm.nih.gov/pubmed/8241274 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000098614 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000098614 RefSeq YP_026188 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026188 SMART SM00861 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00861 SMR P27302 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P27302 STRING 511145.b2935 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2935&targetmode=cogs STRING COG0021 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0021&targetmode=cogs SUPFAM SSF52518 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52518 SUPFAM SSF52922 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52922 TIGRFAMs TIGR00232 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00232 UniProtKB TKT1_ECOLI http://www.uniprot.org/uniprot/TKT1_ECOLI UniProtKB-AC P27302 http://www.uniprot.org/uniprot/P27302 charge swissprot:TKT1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TKT1_ECOLI eggNOG COG0021 http://eggnogapi.embl.de/nog_data/html/tree/COG0021 eggNOG ENOG4105CV1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CV1 epestfind swissprot:TKT1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TKT1_ECOLI garnier swissprot:TKT1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TKT1_ECOLI helixturnhelix swissprot:TKT1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TKT1_ECOLI hmoment swissprot:TKT1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TKT1_ECOLI iep swissprot:TKT1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TKT1_ECOLI inforesidue swissprot:TKT1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TKT1_ECOLI octanol swissprot:TKT1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TKT1_ECOLI pepcoil swissprot:TKT1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TKT1_ECOLI pepdigest swissprot:TKT1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TKT1_ECOLI pepinfo swissprot:TKT1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TKT1_ECOLI pepnet swissprot:TKT1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TKT1_ECOLI pepstats swissprot:TKT1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TKT1_ECOLI pepwheel swissprot:TKT1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TKT1_ECOLI pepwindow swissprot:TKT1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TKT1_ECOLI sigcleave swissprot:TKT1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TKT1_ECOLI ## Database ID URL or Descriptions # FUNCTION INSF6_ECOLI Involved in the transposition of the insertion sequence IS3. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006310 DNA recombination; IEA:UniProtKB-KW. # GO_process GO:0015074 DNA integration; IEA:InterPro. # GO_process GO:0032196 transposition; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 3.30.420.10 -; 1. # InterPro IPR001584 Integrase_cat-core # InterPro IPR012337 RNaseH-like_dom # InterPro IPR025948 HTH-like_dom # Organism INSF6_ECOLI Escherichia coli (strain K12) # PROSITE PS50994 INTEGRASE # Pfam PF00665 rve # Pfam PF13276 HTH_21 # RecName INSF6_ECOLI Transposase InsF for insertion sequence IS3fA # RefSeq NP_061381 NC_002483.1 # RefSeq WP_000878218 NZ_LN832404.1 # SIMILARITY Belongs to the transposase IS3/IS150/IS904 family. {ECO 0000305}. # SIMILARITY Contains 1 integrase catalytic domain. {ECO:0000255|PROSITE-ProRule PRU00457}. # SUPFAM SSF53098 SSF53098 # eggNOG COG2801 LUCA BLAST swissprot:INSF6_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSF6_ECOLI EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0015074 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015074 GO_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 3.30.420.10 http://www.cathdb.info/version/latest/superfamily/3.30.420.10 GeneID 1263587 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263587 InterPro IPR001584 http://www.ebi.ac.uk/interpro/entry/IPR001584 InterPro IPR012337 http://www.ebi.ac.uk/interpro/entry/IPR012337 InterPro IPR025948 http://www.ebi.ac.uk/interpro/entry/IPR025948 PROSITE PS50994 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50994 PSORT swissprot:INSF6_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSF6_ECOLI PSORT-B swissprot:INSF6_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSF6_ECOLI PSORT2 swissprot:INSF6_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSF6_ECOLI Pfam PF00665 http://pfam.xfam.org/family/PF00665 Pfam PF13276 http://pfam.xfam.org/family/PF13276 Phobius swissprot:INSF6_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSF6_ECOLI PhylomeDB P0CF84 http://phylomedb.org/?seqid=P0CF84 ProteinModelPortal P0CF84 http://www.proteinmodelportal.org/query/uniprot/P0CF84 RefSeq NP_061381 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061381 RefSeq WP_000878218 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000878218 SMR P0CF84 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0CF84 STRING 511145.b2089 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2089&targetmode=cogs SUPFAM SSF53098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098 UniProtKB INSF6_ECOLI http://www.uniprot.org/uniprot/INSF6_ECOLI UniProtKB-AC P0CF84 http://www.uniprot.org/uniprot/P0CF84 charge swissprot:INSF6_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSF6_ECOLI eggNOG COG2801 http://eggnogapi.embl.de/nog_data/html/tree/COG2801 epestfind swissprot:INSF6_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSF6_ECOLI garnier swissprot:INSF6_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSF6_ECOLI helixturnhelix swissprot:INSF6_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSF6_ECOLI hmoment swissprot:INSF6_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSF6_ECOLI iep swissprot:INSF6_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSF6_ECOLI inforesidue swissprot:INSF6_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSF6_ECOLI octanol swissprot:INSF6_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSF6_ECOLI pepcoil swissprot:INSF6_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSF6_ECOLI pepdigest swissprot:INSF6_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSF6_ECOLI pepinfo swissprot:INSF6_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSF6_ECOLI pepnet swissprot:INSF6_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSF6_ECOLI pepstats swissprot:INSF6_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSF6_ECOLI pepwheel swissprot:INSF6_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSF6_ECOLI pepwindow swissprot:INSF6_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSF6_ECOLI sigcleave swissprot:INSF6_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSF6_ECOLI ## Database ID URL or Descriptions # AltName Ascorbate-specific permease IIC component UlaA {ECO:0000303|PubMed 12644495} # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=18 uM for L-ascorbate {ECO 0000269|PubMed:12644495}; # BioGrid 4262713 6 # DISRUPTION PHENOTYPE Cells lacking this gene are unable to use L- ascorbate. {ECO:0000269|PubMed 12644495}. # DOMAIN ULAA_ECOLI In classical PTS systems, the PTS EIIC type-2 domain forms the translocation channel and contains the specific substrate- binding site. UlaA does not exhibit the topological features of any recognized enzyme IIC. {ECO 0000305}. # EcoGene EG12493 ulaA # FUNCTION ULAA_ECOLI The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport. {ECO 0000269|PubMed 12644495, ECO 0000305|PubMed 11741871}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0090585 protein-phosphocysteine-L-ascorbate-phosphotransferase system transporter activity; IDA:EcoCyc. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IDA:EcoCyc. # GO_process GO:0015882 L-ascorbic acid transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # INDUCTION ULAA_ECOLI Induced by L-ascorbate. Repressed by UlaR. {ECO 0000269|PubMed 12374842, ECO 0000269|PubMed 12644495, ECO 0000269|PubMed 14996803}. # InterPro IPR004703 PTS_sugar-sp_permease # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00283 PTS system, ascorbate-specific II component # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko00053 Ascorbate and aldarate metabolism # KEGG_Pathway ko02060 Phosphotransferase system (PTS) # Organism ULAA_ECOLI Escherichia coli (strain K12) # PATRIC 32123961 VBIEscCol129921_4325 # PDB 4RP8 X-ray; 2.36 A; A/C=1-465 # PDB 4RP9 X-ray; 1.65 A; A=1-465 # PIR D65230 D65230 # Pfam PF03611 EIIC-GAT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Ascorbate-specific PTS system EIIC component {ECO:0000303|PubMed 12644495} # RefSeq NP_418614 NC_000913.3 # RefSeq WP_001350568 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97089.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the UlaA family. {ECO 0000305}. # SUBCELLULAR LOCATION ULAA_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 25686089}. # TCDB 4.A.7.1 the pts l-ascorbate (l-asc) family # eggNOG COG3037 LUCA # eggNOG ENOG4105CZC Bacteria BLAST swissprot:ULAA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ULAA_ECOLI BioCyc ECOL316407:JW5744-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5744-MONOMER BioCyc EcoCyc:SGAT-MONOMER http://biocyc.org/getid?id=EcoCyc:SGAT-MONOMER BioCyc MetaCyc:SGAT-MONOMER http://biocyc.org/getid?id=MetaCyc:SGAT-MONOMER COG COG3037 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3037 DIP DIP-10870N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10870N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsmb.2975 http://dx.doi.org/10.1038/nsmb.2975 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.1.302-306.2002 http://dx.doi.org/10.1128/JB.184.1.302-306.2002 DOI 10.1128/JB.184.21.6065-6068.2002 http://dx.doi.org/10.1128/JB.184.21.6065-6068.2002 DOI 10.1128/JB.185.7.2243-2250.2003 http://dx.doi.org/10.1128/JB.185.7.2243-2250.2003 DOI 10.1128/JB.186.6.1720-1728.2004 http://dx.doi.org/10.1128/JB.186.6.1720-1728.2004 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2386 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2386 EcoGene EG12493 http://www.ecogene.org/geneInfo.php?eg_id=EG12493 EnsemblBacteria AAC77150 http://www.ensemblgenomes.org/id/AAC77150 EnsemblBacteria AAC77150 http://www.ensemblgenomes.org/id/AAC77150 EnsemblBacteria BAE78194 http://www.ensemblgenomes.org/id/BAE78194 EnsemblBacteria BAE78194 http://www.ensemblgenomes.org/id/BAE78194 EnsemblBacteria BAE78194 http://www.ensemblgenomes.org/id/BAE78194 EnsemblBacteria b4193 http://www.ensemblgenomes.org/id/b4193 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0090585 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090585 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GO_process GO:0015882 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015882 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 948717 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948717 HOGENOM HOG000218566 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218566&db=HOGENOM6 InParanoid P39301 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39301 IntAct P39301 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39301* InterPro IPR004703 http://www.ebi.ac.uk/interpro/entry/IPR004703 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5744 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5744 KEGG_Gene eco:b4193 http://www.genome.jp/dbget-bin/www_bget?eco:b4193 KEGG_Orthology KO:K03475 http://www.genome.jp/dbget-bin/www_bget?KO:K03475 KEGG_Pathway ko00053 http://www.genome.jp/kegg-bin/show_pathway?ko00053 KEGG_Pathway ko02060 http://www.genome.jp/kegg-bin/show_pathway?ko02060 KEGG_Reaction rn:R07671 http://www.genome.jp/dbget-bin/www_bget?rn:R07671 MINT MINT-1255643 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1255643 OMA PNSFGDE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PNSFGDE PDB 4RP8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4RP8 PDB 4RP9 http://www.ebi.ac.uk/pdbe-srv/view/entry/4RP9 PDBsum 4RP8 http://www.ebi.ac.uk/pdbsum/4RP8 PDBsum 4RP9 http://www.ebi.ac.uk/pdbsum/4RP9 PSORT swissprot:ULAA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ULAA_ECOLI PSORT-B swissprot:ULAA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ULAA_ECOLI PSORT2 swissprot:ULAA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ULAA_ECOLI Pfam PF03611 http://pfam.xfam.org/family/PF03611 Phobius swissprot:ULAA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ULAA_ECOLI PhylomeDB P39301 http://phylomedb.org/?seqid=P39301 ProteinModelPortal P39301 http://www.proteinmodelportal.org/query/uniprot/P39301 PubMed 11741871 http://www.ncbi.nlm.nih.gov/pubmed/11741871 PubMed 12374842 http://www.ncbi.nlm.nih.gov/pubmed/12374842 PubMed 12644495 http://www.ncbi.nlm.nih.gov/pubmed/12644495 PubMed 14996803 http://www.ncbi.nlm.nih.gov/pubmed/14996803 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 25686089 http://www.ncbi.nlm.nih.gov/pubmed/25686089 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418614 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418614 RefSeq WP_001350568 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001350568 SMR P39301 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39301 STRING 511145.b4193 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4193&targetmode=cogs STRING COG3037 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3037&targetmode=cogs TCDB 4.A.7.1 http://www.tcdb.org/search/result.php?tc=4.A.7.1 UniProtKB ULAA_ECOLI http://www.uniprot.org/uniprot/ULAA_ECOLI UniProtKB-AC P39301 http://www.uniprot.org/uniprot/P39301 charge swissprot:ULAA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ULAA_ECOLI eggNOG COG3037 http://eggnogapi.embl.de/nog_data/html/tree/COG3037 eggNOG ENOG4105CZC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CZC epestfind swissprot:ULAA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ULAA_ECOLI garnier swissprot:ULAA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ULAA_ECOLI helixturnhelix swissprot:ULAA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ULAA_ECOLI hmoment swissprot:ULAA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ULAA_ECOLI iep swissprot:ULAA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ULAA_ECOLI inforesidue swissprot:ULAA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ULAA_ECOLI octanol swissprot:ULAA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ULAA_ECOLI pepcoil swissprot:ULAA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ULAA_ECOLI pepdigest swissprot:ULAA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ULAA_ECOLI pepinfo swissprot:ULAA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ULAA_ECOLI pepnet swissprot:ULAA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ULAA_ECOLI pepstats swissprot:ULAA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ULAA_ECOLI pepwheel swissprot:ULAA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ULAA_ECOLI pepwindow swissprot:ULAA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ULAA_ECOLI sigcleave swissprot:ULAA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ULAA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259623 13 # EcoGene EG12945 yhhY # GO_component GO:0031248 protein acetyltransferase complex; IBA:GO_Central. # GO_function GO:0004596 peptide alpha-N-acetyltransferase activity; IBA:GO_Central. # GO_function GO:0008080 N-acetyltransferase activity; IDA:EcoCyc. # GO_process GO:0017189 N-terminal peptidyl-alanine acetylation; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0006464 cellular protein modification process # Gene3D 3.40.630.30 -; 1. # IntAct P46854 4 # InterPro IPR000182 GNAT_dom # InterPro IPR016181 Acyl_CoA_acyltransferase # KEGG_Brite ko01000 Enzymes # Organism YHHY_ECOLI Escherichia coli (strain K12) # PATRIC 32122322 VBIEscCol129921_3538 # PIR D65140 D65140 # PROSITE PS51186 GNAT # Pfam PF00583 Acetyltransf_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHHY_ECOLI Uncharacterized N-acetyltransferase YhhY # RefSeq NP_417898 NC_000913.3 # RefSeq WP_001295206 NZ_LN832404.1 # SIMILARITY Belongs to the acetyltransferase family. {ECO 0000305}. # SIMILARITY Contains 1 N-acetyltransferase domain. {ECO:0000255|PROSITE-ProRule PRU00532}. # SUPFAM SSF55729 SSF55729 # eggNOG COG0454 LUCA # eggNOG ENOG4105WCN Bacteria BLAST swissprot:YHHY_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHHY_ECOLI BioCyc ECOL316407:JW3405-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3405-MONOMER BioCyc EcoCyc:G7758-MONOMER http://biocyc.org/getid?id=EcoCyc:G7758-MONOMER COG COG0454 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0454 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 2.3.1.- http://enzyme.expasy.org/EC/2.3.1.- EchoBASE EB2779 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2779 EcoGene EG12945 http://www.ecogene.org/geneInfo.php?eg_id=EG12945 EnsemblBacteria AAC76466 http://www.ensemblgenomes.org/id/AAC76466 EnsemblBacteria AAC76466 http://www.ensemblgenomes.org/id/AAC76466 EnsemblBacteria BAE77852 http://www.ensemblgenomes.org/id/BAE77852 EnsemblBacteria BAE77852 http://www.ensemblgenomes.org/id/BAE77852 EnsemblBacteria BAE77852 http://www.ensemblgenomes.org/id/BAE77852 EnsemblBacteria b3441 http://www.ensemblgenomes.org/id/b3441 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0031248 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031248 GO_function GO:0004596 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004596 GO_function GO:0008080 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008080 GO_process GO:0017189 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017189 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 Gene3D 3.40.630.30 http://www.cathdb.info/version/latest/superfamily/3.40.630.30 GeneID 947943 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947943 HOGENOM HOG000078525 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000078525&db=HOGENOM6 InParanoid P46854 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P46854 IntAct P46854 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P46854* IntEnz 2.3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1 InterPro IPR000182 http://www.ebi.ac.uk/interpro/entry/IPR000182 InterPro IPR016181 http://www.ebi.ac.uk/interpro/entry/IPR016181 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3405 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3405 KEGG_Gene eco:b3441 http://www.genome.jp/dbget-bin/www_bget?eco:b3441 KEGG_Orthology KO:K03825 http://www.genome.jp/dbget-bin/www_bget?KO:K03825 OMA FGMGVKD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FGMGVKD PROSITE PS51186 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51186 PSORT swissprot:YHHY_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHHY_ECOLI PSORT-B swissprot:YHHY_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHHY_ECOLI PSORT2 swissprot:YHHY_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHHY_ECOLI Pfam PF00583 http://pfam.xfam.org/family/PF00583 Phobius swissprot:YHHY_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHHY_ECOLI PhylomeDB P46854 http://phylomedb.org/?seqid=P46854 ProteinModelPortal P46854 http://www.proteinmodelportal.org/query/uniprot/P46854 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417898 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417898 RefSeq WP_001295206 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295206 SMR P46854 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P46854 STRING 511145.b3441 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3441&targetmode=cogs STRING COG0454 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0454&targetmode=cogs SUPFAM SSF55729 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55729 UniProtKB YHHY_ECOLI http://www.uniprot.org/uniprot/YHHY_ECOLI UniProtKB-AC P46854 http://www.uniprot.org/uniprot/P46854 charge swissprot:YHHY_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHHY_ECOLI eggNOG COG0454 http://eggnogapi.embl.de/nog_data/html/tree/COG0454 eggNOG ENOG4105WCN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105WCN epestfind swissprot:YHHY_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHHY_ECOLI garnier swissprot:YHHY_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHHY_ECOLI helixturnhelix swissprot:YHHY_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHHY_ECOLI hmoment swissprot:YHHY_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHHY_ECOLI iep swissprot:YHHY_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHHY_ECOLI inforesidue swissprot:YHHY_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHHY_ECOLI octanol swissprot:YHHY_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHHY_ECOLI pepcoil swissprot:YHHY_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHHY_ECOLI pepdigest swissprot:YHHY_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHHY_ECOLI pepinfo swissprot:YHHY_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHHY_ECOLI pepnet swissprot:YHHY_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHHY_ECOLI pepstats swissprot:YHHY_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHHY_ECOLI pepwheel swissprot:YHHY_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHHY_ECOLI pepwindow swissprot:YHHY_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHHY_ECOLI sigcleave swissprot:YHHY_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHHY_ECOLI ## Database ID URL or Descriptions # BioGrid 4262158 8 # EcoGene EG12254 yhjJ # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_function GO:0004222 metalloendopeptidase activity; IBA:GO_Central. # GO_function GO:0008270 zinc ion binding; IBA:GO_Central. # GO_process GO:0016485 protein processing; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0008233 peptidase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0051604 protein maturation # Gene3D 3.30.830.10 -; 1. # IntAct P37648 2 # InterPro IPR007863 Peptidase_M16_C # InterPro IPR011237 Pept_M16_dom # InterPro IPR011249 Metalloenz_LuxS/M16 # InterPro IPR011765 Pept_M16_N # MISCELLANEOUS YHJJ_ECOLI Has lost the active site residues. # Organism YHJJ_ECOLI Escherichia coli (strain K12) # PATRIC 32122518 VBIEscCol129921_3637 # PIR S47748 S47748 # Pfam PF00675 Peptidase_M16 # Pfam PF05193 Peptidase_M16_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHJJ_ECOLI Protein YhjJ # RefSeq NP_417984 NC_000913.3 # RefSeq WP_001163141 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase M16 family. {ECO 0000305}. # SUBCELLULAR LOCATION YHJJ_ECOLI Periplasm {ECO 0000305}. # SUPFAM SSF63411 SSF63411; 2 # eggNOG COG0612 LUCA # eggNOG ENOG4105CS0 Bacteria BLAST swissprot:YHJJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHJJ_ECOLI BioCyc ECOL316407:JW3495-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3495-MONOMER BioCyc EcoCyc:EG12254-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12254-MONOMER DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2164 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2164 EcoGene EG12254 http://www.ecogene.org/geneInfo.php?eg_id=EG12254 EnsemblBacteria AAC76552 http://www.ensemblgenomes.org/id/AAC76552 EnsemblBacteria AAC76552 http://www.ensemblgenomes.org/id/AAC76552 EnsemblBacteria BAE77767 http://www.ensemblgenomes.org/id/BAE77767 EnsemblBacteria BAE77767 http://www.ensemblgenomes.org/id/BAE77767 EnsemblBacteria BAE77767 http://www.ensemblgenomes.org/id/BAE77767 EnsemblBacteria b3527 http://www.ensemblgenomes.org/id/b3527 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0004222 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004222 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_process GO:0016485 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016485 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 Gene3D 3.30.830.10 http://www.cathdb.info/version/latest/superfamily/3.30.830.10 GeneID 948040 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948040 HOGENOM HOG000125913 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125913&db=HOGENOM6 InParanoid P37648 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37648 IntAct P37648 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37648* InterPro IPR007863 http://www.ebi.ac.uk/interpro/entry/IPR007863 InterPro IPR011237 http://www.ebi.ac.uk/interpro/entry/IPR011237 InterPro IPR011249 http://www.ebi.ac.uk/interpro/entry/IPR011249 InterPro IPR011765 http://www.ebi.ac.uk/interpro/entry/IPR011765 KEGG_Gene ecj:JW3495 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3495 KEGG_Gene eco:b3527 http://www.genome.jp/dbget-bin/www_bget?eco:b3527 OMA QCAIHLD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QCAIHLD PSORT swissprot:YHJJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHJJ_ECOLI PSORT-B swissprot:YHJJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHJJ_ECOLI PSORT2 swissprot:YHJJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHJJ_ECOLI Pfam PF00675 http://pfam.xfam.org/family/PF00675 Pfam PF05193 http://pfam.xfam.org/family/PF05193 Phobius swissprot:YHJJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHJJ_ECOLI PhylomeDB P37648 http://phylomedb.org/?seqid=P37648 ProteinModelPortal P37648 http://www.proteinmodelportal.org/query/uniprot/P37648 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_417984 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417984 RefSeq WP_001163141 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001163141 SMR P37648 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37648 STRING 511145.b3527 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3527&targetmode=cogs SUPFAM SSF63411 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63411 UniProtKB YHJJ_ECOLI http://www.uniprot.org/uniprot/YHJJ_ECOLI UniProtKB-AC P37648 http://www.uniprot.org/uniprot/P37648 charge swissprot:YHJJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHJJ_ECOLI eggNOG COG0612 http://eggnogapi.embl.de/nog_data/html/tree/COG0612 eggNOG ENOG4105CS0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CS0 epestfind swissprot:YHJJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHJJ_ECOLI garnier swissprot:YHJJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHJJ_ECOLI helixturnhelix swissprot:YHJJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHJJ_ECOLI hmoment swissprot:YHJJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHJJ_ECOLI iep swissprot:YHJJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHJJ_ECOLI inforesidue swissprot:YHJJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHJJ_ECOLI octanol swissprot:YHJJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHJJ_ECOLI pepcoil swissprot:YHJJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHJJ_ECOLI pepdigest swissprot:YHJJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHJJ_ECOLI pepinfo swissprot:YHJJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHJJ_ECOLI pepnet swissprot:YHJJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHJJ_ECOLI pepstats swissprot:YHJJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHJJ_ECOLI pepwheel swissprot:YHJJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHJJ_ECOLI pepwindow swissprot:YHJJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHJJ_ECOLI sigcleave swissprot:YHJJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHJJ_ECOLI ## Database ID URL or Descriptions # AltName CYSD_ECOLI ATP-sulfurylase small subunit # AltName CYSD_ECOLI Sulfate adenylate transferase # BioGrid 4263040 15 # CATALYTIC ACTIVITY CYSD_ECOLI ATP + sulfate = diphosphate + adenylyl sulfate. # CDD cd01713 PAPS_reductase # ENZYME REGULATION CYSD_ECOLI Stimulated by an intrinsic GTPase (Probably CysN). # EcoGene EG10186 cysD # GO_function GO:0004781 sulfate adenylyltransferase (ATP) activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_process GO:0000103 sulfate assimilation; IEA:UniProtKB-HAMAP. # GO_process GO:0006790 sulfur compound metabolic process; IDA:EcoCyc. # GO_process GO:0006979 response to oxidative stress; IMP:EcoCyc. # GO_process GO:0019419 sulfate reduction; IEA:InterPro. # GO_process GO:0070814 hydrogen sulfide biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.50.620 -; 2. # HAMAP MF_00064 Sulf_adenylyltr_sub2 # IntAct P21156 5 # InterPro IPR002500 PAPS_reduct # InterPro IPR011784 SO4_adenylTrfase_ssu # InterPro IPR014729 Rossmann-like_a/b/a_fold # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00450 Selenocompound metabolism # KEGG_Pathway ko00920 Sulfur metabolism # Organism CYSD_ECOLI Escherichia coli (strain K12) # PATHWAY Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate step 1/3. # PATRIC 32120910 VBIEscCol129921_2847 # PIR D65056 D65056 # PIRSF PIRSF002936 CysDAde_trans # Pfam PF01507 PAPS_reduct # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CYSD_ECOLI Sulfate adenylyltransferase subunit 2 # RefSeq NP_417232 NC_000913.3 # RefSeq WP_000372108 NZ_LN832404.1 # SIMILARITY Belongs to the PAPS reductase family. CysD subfamily. {ECO 0000305}. # SUBUNIT CYSD_ECOLI Heterodimer composed of CysD, the smaller subunit, and CysN. # TIGRFAMs TIGR02039 CysD # UniPathway UPA00140 UER00204 # eggNOG COG0175 LUCA # eggNOG ENOG4105C11 Bacteria BLAST swissprot:CYSD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CYSD_ECOLI BioCyc ECOL316407:JW2722-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2722-MONOMER BioCyc EcoCyc:CYSD-MONOMER http://biocyc.org/getid?id=EcoCyc:CYSD-MONOMER BioCyc MetaCyc:CYSD-MONOMER http://biocyc.org/getid?id=MetaCyc:CYSD-MONOMER COG COG0175 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0175 DIP DIP-360N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-360N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0378-1119(90)90504-K http://dx.doi.org/10.1016/0378-1119(90)90504-K DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.7.4 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.4 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M35098 http://www.ebi.ac.uk/ena/data/view/M35098 EMBL M74586 http://www.ebi.ac.uk/ena/data/view/M74586 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 ENZYME 2.7.7.4 http://enzyme.expasy.org/EC/2.7.7.4 EchoBASE EB0183 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0183 EcoGene EG10186 http://www.ecogene.org/geneInfo.php?eg_id=EG10186 EnsemblBacteria AAC75794 http://www.ensemblgenomes.org/id/AAC75794 EnsemblBacteria AAC75794 http://www.ensemblgenomes.org/id/AAC75794 EnsemblBacteria BAE76829 http://www.ensemblgenomes.org/id/BAE76829 EnsemblBacteria BAE76829 http://www.ensemblgenomes.org/id/BAE76829 EnsemblBacteria BAE76829 http://www.ensemblgenomes.org/id/BAE76829 EnsemblBacteria b2752 http://www.ensemblgenomes.org/id/b2752 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004781 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004781 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0000103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000103 GO_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GO_process GO:0006979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979 GO_process GO:0019419 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019419 GO_process GO:0070814 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070814 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 GeneID 947217 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947217 HAMAP MF_00064 http://hamap.expasy.org/unirule/MF_00064 HOGENOM HOG000263604 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000263604&db=HOGENOM6 InParanoid P21156 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P21156 IntAct P21156 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P21156* IntEnz 2.7.7.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.4 InterPro IPR002500 http://www.ebi.ac.uk/interpro/entry/IPR002500 InterPro IPR011784 http://www.ebi.ac.uk/interpro/entry/IPR011784 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2722 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2722 KEGG_Gene eco:b2752 http://www.genome.jp/dbget-bin/www_bget?eco:b2752 KEGG_Orthology KO:K00957 http://www.genome.jp/dbget-bin/www_bget?KO:K00957 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00450 http://www.genome.jp/kegg-bin/show_pathway?ko00450 KEGG_Pathway ko00920 http://www.genome.jp/kegg-bin/show_pathway?ko00920 KEGG_Reaction rn:R00529 http://www.genome.jp/dbget-bin/www_bget?rn:R00529 KEGG_Reaction rn:R04929 http://www.genome.jp/dbget-bin/www_bget?rn:R04929 OMA QSASMEK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QSASMEK PSORT swissprot:CYSD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CYSD_ECOLI PSORT-B swissprot:CYSD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CYSD_ECOLI PSORT2 swissprot:CYSD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CYSD_ECOLI Pfam PF01507 http://pfam.xfam.org/family/PF01507 Phobius swissprot:CYSD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CYSD_ECOLI PhylomeDB P21156 http://phylomedb.org/?seqid=P21156 ProteinModelPortal P21156 http://www.proteinmodelportal.org/query/uniprot/P21156 PubMed 1316900 http://www.ncbi.nlm.nih.gov/pubmed/1316900 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2185135 http://www.ncbi.nlm.nih.gov/pubmed/2185135 PubMed 2828368 http://www.ncbi.nlm.nih.gov/pubmed/2828368 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417232 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417232 RefSeq WP_000372108 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000372108 SMR P21156 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P21156 STRING 511145.b2752 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2752&targetmode=cogs STRING COG0175 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0175&targetmode=cogs TIGRFAMs TIGR02039 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02039 UniProtKB CYSD_ECOLI http://www.uniprot.org/uniprot/CYSD_ECOLI UniProtKB-AC P21156 http://www.uniprot.org/uniprot/P21156 charge swissprot:CYSD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CYSD_ECOLI eggNOG COG0175 http://eggnogapi.embl.de/nog_data/html/tree/COG0175 eggNOG ENOG4105C11 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C11 epestfind swissprot:CYSD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CYSD_ECOLI garnier swissprot:CYSD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CYSD_ECOLI helixturnhelix swissprot:CYSD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CYSD_ECOLI hmoment swissprot:CYSD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CYSD_ECOLI iep swissprot:CYSD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CYSD_ECOLI inforesidue swissprot:CYSD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CYSD_ECOLI octanol swissprot:CYSD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CYSD_ECOLI pepcoil swissprot:CYSD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CYSD_ECOLI pepdigest swissprot:CYSD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CYSD_ECOLI pepinfo swissprot:CYSD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CYSD_ECOLI pepnet swissprot:CYSD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CYSD_ECOLI pepstats swissprot:CYSD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CYSD_ECOLI pepwheel swissprot:CYSD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CYSD_ECOLI pepwindow swissprot:CYSD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CYSD_ECOLI sigcleave swissprot:CYSD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CYSD_ECOLI ## Database ID URL or Descriptions # EcoGene EG13951 ydhQ # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_process GO:0006950 response to stress # Gene3D 2.160.20.20 -; 1. # IntAct P77552 15 # InterPro IPR004899 Pertactin_central # InterPro IPR011050 Pectin_lyase_fold/virulence # InterPro IPR012332 P22_tailspike_C-like # InterPro IPR030930 AIDA # Organism YDHQ_ECOLI Escherichia coli (strain K12) # PATRIC 32118634 VBIEscCol129921_1737 # PIR B64924 B64924 # Pfam PF03212 Pertactin # Pfam PF16168 AIDA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDHQ_ECOLI Uncharacterized protein YdhQ # RefSeq NP_416181 NC_000913.3 # RefSeq WP_000534271 NZ_LN832404.1 # SUPFAM SSF51126 SSF51126 # TIGRFAMs TIGR04415 O_hepto_targRPT # eggNOG COG3468 LUCA BLAST swissprot:YDHQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDHQ_ECOLI BioCyc ECOL316407:JW1656-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1656-MONOMER BioCyc EcoCyc:G6894-MONOMER http://biocyc.org/getid?id=EcoCyc:G6894-MONOMER DIP DIP-28088N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-28088N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U68703 http://www.ebi.ac.uk/ena/data/view/U68703 EchoBASE EB3709 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3709 EcoGene EG13951 http://www.ecogene.org/geneInfo.php?eg_id=EG13951 EnsemblBacteria AAC74736 http://www.ensemblgenomes.org/id/AAC74736 EnsemblBacteria AAC74736 http://www.ensemblgenomes.org/id/AAC74736 EnsemblBacteria BAA15431 http://www.ensemblgenomes.org/id/BAA15431 EnsemblBacteria BAA15431 http://www.ensemblgenomes.org/id/BAA15431 EnsemblBacteria BAA15431 http://www.ensemblgenomes.org/id/BAA15431 EnsemblBacteria b1664 http://www.ensemblgenomes.org/id/b1664 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 2.160.20.20 http://www.cathdb.info/version/latest/superfamily/2.160.20.20 GeneID 944851 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944851 HOGENOM HOG000120908 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120908&db=HOGENOM6 IntAct P77552 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77552* InterPro IPR004899 http://www.ebi.ac.uk/interpro/entry/IPR004899 InterPro IPR011050 http://www.ebi.ac.uk/interpro/entry/IPR011050 InterPro IPR012332 http://www.ebi.ac.uk/interpro/entry/IPR012332 InterPro IPR030930 http://www.ebi.ac.uk/interpro/entry/IPR030930 KEGG_Gene ecj:JW1656 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1656 KEGG_Gene eco:b1664 http://www.genome.jp/dbget-bin/www_bget?eco:b1664 OMA ACNCEIN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ACNCEIN PSORT swissprot:YDHQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDHQ_ECOLI PSORT-B swissprot:YDHQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDHQ_ECOLI PSORT2 swissprot:YDHQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDHQ_ECOLI Pfam PF03212 http://pfam.xfam.org/family/PF03212 Pfam PF16168 http://pfam.xfam.org/family/PF16168 Phobius swissprot:YDHQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDHQ_ECOLI PhylomeDB P77552 http://phylomedb.org/?seqid=P77552 ProteinModelPortal P77552 http://www.proteinmodelportal.org/query/uniprot/P77552 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9023191 http://www.ncbi.nlm.nih.gov/pubmed/9023191 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416181 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416181 RefSeq WP_000534271 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000534271 SMR P77552 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77552 STRING 511145.b1664 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1664&targetmode=cogs SUPFAM SSF51126 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51126 TIGRFAMs TIGR04415 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR04415 UniProtKB YDHQ_ECOLI http://www.uniprot.org/uniprot/YDHQ_ECOLI UniProtKB-AC P77552 http://www.uniprot.org/uniprot/P77552 charge swissprot:YDHQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDHQ_ECOLI eggNOG COG3468 http://eggnogapi.embl.de/nog_data/html/tree/COG3468 epestfind swissprot:YDHQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDHQ_ECOLI garnier swissprot:YDHQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDHQ_ECOLI helixturnhelix swissprot:YDHQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDHQ_ECOLI hmoment swissprot:YDHQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDHQ_ECOLI iep swissprot:YDHQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDHQ_ECOLI inforesidue swissprot:YDHQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDHQ_ECOLI octanol swissprot:YDHQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDHQ_ECOLI pepcoil swissprot:YDHQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDHQ_ECOLI pepdigest swissprot:YDHQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDHQ_ECOLI pepinfo swissprot:YDHQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDHQ_ECOLI pepnet swissprot:YDHQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDHQ_ECOLI pepstats swissprot:YDHQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDHQ_ECOLI pepwheel swissprot:YDHQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDHQ_ECOLI pepwindow swissprot:YDHQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDHQ_ECOLI sigcleave swissprot:YDHQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDHQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4259451 7 # DISRUPTION PHENOTYPE Not essential, no change in sensitivity to reductant (beta-mercaptoethanol), may not play a role in cytochrome bd-I oxidase. {ECO:0000269|PubMed 23749980}. # EcoGene EG12395 ybgE # IntAct P0AAV0 2 # InterPro IPR011846 Cyd_oper_YbgE # Organism YBGE_ECOLI Escherichia coli (strain K12) # PATRIC 32116669 VBIEscCol129921_0767 # PIR F64809 F64809 # Pfam PF09600 Cyd_oper_YbgE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBGE_ECOLI Uncharacterized protein YbgE # RefSeq NP_415263 NC_000913.3 # RefSeq WP_000034602 NZ_LN832404.1 # TCDB 8.A.79.1 the 3 tms cyd operon protein, cydx (cydx) family # TIGRFAMs TIGR02112 cyd_oper_ybgE # eggNOG COG3790 LUCA # eggNOG ENOG4105KJB Bacteria BLAST swissprot:YBGE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBGE_ECOLI BioCyc ECOL316407:JW0725-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0725-MONOMER BioCyc EcoCyc:EG12395-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12395-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00324-13 http://dx.doi.org/10.1128/JB.00324-13 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J03939 http://www.ebi.ac.uk/ena/data/view/J03939 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U30934 http://www.ebi.ac.uk/ena/data/view/U30934 EchoBASE EB2296 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2296 EcoGene EG12395 http://www.ecogene.org/geneInfo.php?eg_id=EG12395 EnsemblBacteria AAC73829 http://www.ensemblgenomes.org/id/AAC73829 EnsemblBacteria AAC73829 http://www.ensemblgenomes.org/id/AAC73829 EnsemblBacteria BAA35401 http://www.ensemblgenomes.org/id/BAA35401 EnsemblBacteria BAA35401 http://www.ensemblgenomes.org/id/BAA35401 EnsemblBacteria BAA35401 http://www.ensemblgenomes.org/id/BAA35401 EnsemblBacteria b0735 http://www.ensemblgenomes.org/id/b0735 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945326 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945326 HOGENOM HOG000283081 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000283081&db=HOGENOM6 IntAct P0AAV0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAV0* InterPro IPR011846 http://www.ebi.ac.uk/interpro/entry/IPR011846 KEGG_Gene ecj:JW0725 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0725 KEGG_Gene eco:b0735 http://www.genome.jp/dbget-bin/www_bget?eco:b0735 OMA MDKSPLR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MDKSPLR PSORT swissprot:YBGE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBGE_ECOLI PSORT-B swissprot:YBGE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBGE_ECOLI PSORT2 swissprot:YBGE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBGE_ECOLI Pfam PF09600 http://pfam.xfam.org/family/PF09600 Phobius swissprot:YBGE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBGE_ECOLI ProteinModelPortal P0AAV0 http://www.proteinmodelportal.org/query/uniprot/P0AAV0 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 23749980 http://www.ncbi.nlm.nih.gov/pubmed/23749980 PubMed 2843510 http://www.ncbi.nlm.nih.gov/pubmed/2843510 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9068659 http://www.ncbi.nlm.nih.gov/pubmed/9068659 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415263 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415263 RefSeq WP_000034602 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000034602 STRING 511145.b0735 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0735&targetmode=cogs TCDB 8.A.79.1 http://www.tcdb.org/search/result.php?tc=8.A.79.1 TIGRFAMs TIGR02112 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02112 UniProtKB YBGE_ECOLI http://www.uniprot.org/uniprot/YBGE_ECOLI UniProtKB-AC P0AAV0 http://www.uniprot.org/uniprot/P0AAV0 charge swissprot:YBGE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBGE_ECOLI eggNOG COG3790 http://eggnogapi.embl.de/nog_data/html/tree/COG3790 eggNOG ENOG4105KJB http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KJB epestfind swissprot:YBGE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBGE_ECOLI garnier swissprot:YBGE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBGE_ECOLI helixturnhelix swissprot:YBGE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBGE_ECOLI hmoment swissprot:YBGE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBGE_ECOLI iep swissprot:YBGE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBGE_ECOLI inforesidue swissprot:YBGE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBGE_ECOLI octanol swissprot:YBGE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBGE_ECOLI pepcoil swissprot:YBGE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBGE_ECOLI pepdigest swissprot:YBGE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBGE_ECOLI pepinfo swissprot:YBGE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBGE_ECOLI pepnet swissprot:YBGE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBGE_ECOLI pepstats swissprot:YBGE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBGE_ECOLI pepwheel swissprot:YBGE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBGE_ECOLI pepwindow swissprot:YBGE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBGE_ECOLI sigcleave swissprot:YBGE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBGE_ECOLI ## Database ID URL or Descriptions # BioGrid 4259418 6 # EcoGene EG14002 ydjZ # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # InterPro IPR015414 TMEM64/TMEM41 # InterPro IPR032816 SNARE_assoc # Organism YDJZ_ECOLI Escherichia coli (strain K12) # PANTHER PTHR12677 PTHR12677 # PATRIC 32118815 VBIEscCol129921_1825 # PIR H64934 H64934 # Pfam PF09335 SNARE_assoc # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDJZ_ECOLI TVP38/TMEM64 family inner membrane protein YdjZ # RefSeq NP_416266 NC_000913.3 # RefSeq WP_000980098 NZ_LN832404.1 # SIMILARITY Belongs to the TVP38/TMEM64 family. {ECO 0000305}. # SUBCELLULAR LOCATION YDJZ_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 9.B.27.1 the deda or ydjx-z (deda) family # eggNOG COG0398 LUCA # eggNOG ENOG4108N5C Bacteria BLAST swissprot:YDJZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDJZ_ECOLI BioCyc ECOL316407:JW1741-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1741-MONOMER BioCyc EcoCyc:G6947-MONOMER http://biocyc.org/getid?id=EcoCyc:G6947-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3758 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3758 EcoGene EG14002 http://www.ecogene.org/geneInfo.php?eg_id=EG14002 EnsemblBacteria AAC74822 http://www.ensemblgenomes.org/id/AAC74822 EnsemblBacteria AAC74822 http://www.ensemblgenomes.org/id/AAC74822 EnsemblBacteria BAE76519 http://www.ensemblgenomes.org/id/BAE76519 EnsemblBacteria BAE76519 http://www.ensemblgenomes.org/id/BAE76519 EnsemblBacteria BAE76519 http://www.ensemblgenomes.org/id/BAE76519 EnsemblBacteria b1752 http://www.ensemblgenomes.org/id/b1752 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 946269 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946269 HOGENOM HOG000066621 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000066621&db=HOGENOM6 InParanoid P76221 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76221 InterPro IPR015414 http://www.ebi.ac.uk/interpro/entry/IPR015414 InterPro IPR032816 http://www.ebi.ac.uk/interpro/entry/IPR032816 KEGG_Gene ecj:JW1741 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1741 KEGG_Gene eco:b1752 http://www.genome.jp/dbget-bin/www_bget?eco:b1752 OMA KIDAQQP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KIDAQQP PANTHER PTHR12677 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12677 PSORT swissprot:YDJZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDJZ_ECOLI PSORT-B swissprot:YDJZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDJZ_ECOLI PSORT2 swissprot:YDJZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDJZ_ECOLI Pfam PF09335 http://pfam.xfam.org/family/PF09335 Phobius swissprot:YDJZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDJZ_ECOLI PhylomeDB P76221 http://phylomedb.org/?seqid=P76221 ProteinModelPortal P76221 http://www.proteinmodelportal.org/query/uniprot/P76221 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416266 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416266 RefSeq WP_000980098 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000980098 STRING 511145.b1752 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1752&targetmode=cogs TCDB 9.B.27.1 http://www.tcdb.org/search/result.php?tc=9.B.27.1 UniProtKB YDJZ_ECOLI http://www.uniprot.org/uniprot/YDJZ_ECOLI UniProtKB-AC P76221 http://www.uniprot.org/uniprot/P76221 charge swissprot:YDJZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDJZ_ECOLI eggNOG COG0398 http://eggnogapi.embl.de/nog_data/html/tree/COG0398 eggNOG ENOG4108N5C http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108N5C epestfind swissprot:YDJZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDJZ_ECOLI garnier swissprot:YDJZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDJZ_ECOLI helixturnhelix swissprot:YDJZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDJZ_ECOLI hmoment swissprot:YDJZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDJZ_ECOLI iep swissprot:YDJZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDJZ_ECOLI inforesidue swissprot:YDJZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDJZ_ECOLI octanol swissprot:YDJZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDJZ_ECOLI pepcoil swissprot:YDJZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDJZ_ECOLI pepdigest swissprot:YDJZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDJZ_ECOLI pepinfo swissprot:YDJZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDJZ_ECOLI pepnet swissprot:YDJZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDJZ_ECOLI pepstats swissprot:YDJZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDJZ_ECOLI pepwheel swissprot:YDJZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDJZ_ECOLI pepwindow swissprot:YDJZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDJZ_ECOLI sigcleave swissprot:YDJZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDJZ_ECOLI ## Database ID URL or Descriptions # AltName PHOU_ECOLI Negative regulator of Pho regulon # BioGrid 4262141 13 # CAUTION Was originally thought to be involved in phosphate transport. {ECO:0000305|PubMed 1459954}. # DISRUPTION PHENOTYPE PHOU_ECOLI Produces high level of alkaline phosphatase (AP) when grown with excess phosphate (PubMed 1459954). No effect on phosphate uptake, but particular deletion mutants have a severe growth defect, which is largely alleviated by a compensatory mutation in the pstSCAB genes or in the phoRB operon (PubMed 8226621). Accumulates high levels of polyP, approximately 400 nmol of phosphate residues/mg of protein (PubMed 12147514). Higher susceptibility to a diverse range of antibiotics including ampicillin, norfloxacin and gentamicin, and stresses such as starvation, acid pH, heat, peroxide, weak acids and energy inhibitors, especially in stationary phase (PubMed 17420206). Metabolically hyperactive status of the cell showing increased expression of energy production genes, flagella and chemotaxis genes, and a defect in persister formation (PubMed 17420206). Cells transport phosphate via PstSCAB transporter system at approximately 20% higher rate and accumulate higher levels of the transporter and about 50% more phosphate in 12 minutes than wild- type cells in phosphate-replete medium (PubMed 19047379). {ECO 0000269|PubMed 12147514, ECO 0000269|PubMed 1459954, ECO 0000269|PubMed 17420206, ECO 0000269|PubMed 19047379, ECO 0000269|PubMed 8226621}. # EcoGene EG10735 phoU # FUNCTION PHOU_ECOLI Part of the phosphate (Pho) regulon, which plays a key role in phosphate homeostasis. Encoded together with proteins of the phosphate-specific transport (Pst) system in the polycistronic pstSCAB-phoU operon. PhoU is essential for the repression of the Pho regulon at high phosphate conditions. In this role, it may bind, possibly as a chaperone, to PhoR, PhoB or a PhoR-PhoB complex to promote dephosphorylation of phospho-PhoB, or inhibit formation of the PhoR-PhoB transitory complex. Is also part of complex networks important for bacterial virulence, tolerance to antibiotics and stress response. {ECO 0000269|PubMed 17420206, ECO 0000269|PubMed 6310121}. # GO_component GO:0005737 cytoplasm; IDA:UniProtKB. # GO_component GO:0019897 extrinsic component of plasma membrane; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0005315 inorganic phosphate transmembrane transporter activity; IBA:GO_Central. # GO_function GO:0015321 sodium-dependent phosphate transmembrane transporter activity; IBA:GO_Central. # GO_function GO:0030145 manganese ion binding; IDA:EcoCyc. # GO_function GO:0042803 protein homodimerization activity; ISS:UniProtKB. # GO_function PHOU_ECOLI GO 0005436 sodium phosphate symporter activity; IBA GO_Central. # GO_process GO:0001558 regulation of cell growth; IMP:UniProtKB. # GO_process GO:0009267 cellular response to starvation; IMP:UniProtKB. # GO_process GO:0009405 pathogenesis; IMP:UniProtKB. # GO_process GO:0010629 negative regulation of gene expression; IMP:UniProtKB. # GO_process GO:0016036 cellular response to phosphate starvation; IEP:UniProtKB. # GO_process GO:0030643 cellular phosphate ion homeostasis; TAS:UniProtKB. # GO_process GO:0032413 negative regulation of ion transmembrane transporter activity; IMP:UniProtKB. # GO_process GO:0034605 cellular response to heat; IMP:UniProtKB. # GO_process GO:0045936 negative regulation of phosphate metabolic process; IMP:UniProtKB. # GO_process GO:0071236 cellular response to antibiotic; IMP:UniProtKB. # GO_process GO:0071467 cellular response to pH; IMP:UniProtKB. # GO_process GO:2000186 negative regulation of phosphate transmembrane transport; IMP:UniProtKB. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0042592 homeostatic process # INDUCTION PHOU_ECOLI Expressed at higher levels under excess phosphate culture conditions (PubMed 6090402). Induced by phosphate starvation via the PhoR/PhoB two-component regulatory system (PubMed 18031348). {ECO 0000269|PubMed 18031348, ECO 0000269|PubMed 6090402}. # InterPro IPR026022 PhoU_dom # InterPro IPR028366 P_trasport_PhoU # Organism PHOU_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10010:SF14 PTHR10010:SF14 # PATRIC 32122945 VBIEscCol129921_3848 # PHARMACEUTICAL PHOU_ECOLI May be a drug target for designing new drugs that kill persister bacteria for more effective control of bacterial infections. # PIR D23311 BVECPU # PIRSF PIRSF003107 PhoU # Pfam PF01895 PhoU; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PHOU_ECOLI Phosphate-specific transport system accessory protein PhoU # RefSeq NP_418180 NC_000913.3 # RefSeq WP_000377786 NZ_LN832404.1 # SIMILARITY Belongs to the PhoU family. {ECO 0000305}. # SUBCELLULAR LOCATION PHOU_ECOLI Cytoplasm {ECO 0000269|PubMed 3536855}. # SUBUNIT Homodimer. {ECO 0000250}. # TIGRFAMs TIGR02135 phoU_full # eggNOG COG0704 LUCA # eggNOG ENOG4108UTW Bacteria BLAST swissprot:PHOU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PHOU_ECOLI BioCyc ECOL316407:JW3702-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3702-MONOMER BioCyc EcoCyc:EG10735-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10735-MONOMER COG COG0704 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0704 DIP DIP-10503N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10503N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1007/s00438-002-0764-4 http://dx.doi.org/10.1007/s00438-002-0764-4 DOI 10.1016/0022-2836(85)90377-8 http://dx.doi.org/10.1016/0022-2836(85)90377-8 DOI 10.1016/S0022-2836(83)80297-6 http://dx.doi.org/10.1016/S0022-2836(83)80297-6 DOI 10.1016/j.mib.2010.01.014 http://dx.doi.org/10.1016/j.mib.2010.01.014 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1574-6968.2007.00965.x http://dx.doi.org/10.1111/j.1574-6968.2007.00965.x DOI 10.1111/j.1574-6976.2008.00101.x http://dx.doi.org/10.1111/j.1574-6976.2008.00101.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AAC.00052-07 http://dx.doi.org/10.1128/AAC.00052-07 DOI 10.1128/AEM.01046-08 http://dx.doi.org/10.1128/AEM.01046-08 DOI 10.1128/AEM.68.8.4107-4110.2002 http://dx.doi.org/10.1128/AEM.68.8.4107-4110.2002 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K01992 http://www.ebi.ac.uk/ena/data/view/K01992 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M16487 http://www.ebi.ac.uk/ena/data/view/M16487 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X02723 http://www.ebi.ac.uk/ena/data/view/X02723 EchoBASE EB0728 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0728 EcoGene EG10735 http://www.ecogene.org/geneInfo.php?eg_id=EG10735 EnsemblBacteria AAC76747 http://www.ensemblgenomes.org/id/AAC76747 EnsemblBacteria AAC76747 http://www.ensemblgenomes.org/id/AAC76747 EnsemblBacteria BAE77564 http://www.ensemblgenomes.org/id/BAE77564 EnsemblBacteria BAE77564 http://www.ensemblgenomes.org/id/BAE77564 EnsemblBacteria BAE77564 http://www.ensemblgenomes.org/id/BAE77564 EnsemblBacteria b3724 http://www.ensemblgenomes.org/id/b3724 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0019897 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019897 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0005315 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005315 GO_function GO:0005436 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005436 GO_function GO:0015321 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015321 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_function GO:0042803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803 GO_process GO:0001558 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001558 GO_process GO:0009267 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009267 GO_process GO:0009405 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009405 GO_process GO:0010629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010629 GO_process GO:0016036 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016036 GO_process GO:0030643 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030643 GO_process GO:0032413 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032413 GO_process GO:0034605 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034605 GO_process GO:0045936 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045936 GO_process GO:0071236 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071236 GO_process GO:0071467 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071467 GO_process GO:2000186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000186 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GeneID 948233 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948233 HOGENOM HOG000074025 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000074025&db=HOGENOM6 InParanoid P0A9K7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9K7 IntAct P0A9K7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9K7* InterPro IPR026022 http://www.ebi.ac.uk/interpro/entry/IPR026022 InterPro IPR028366 http://www.ebi.ac.uk/interpro/entry/IPR028366 KEGG_Gene ecj:JW3702 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3702 KEGG_Gene eco:b3724 http://www.genome.jp/dbget-bin/www_bget?eco:b3724 KEGG_Orthology KO:K02039 http://www.genome.jp/dbget-bin/www_bget?KO:K02039 OMA ELATYMM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ELATYMM PANTHER PTHR10010:SF14 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10010:SF14 PSORT swissprot:PHOU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PHOU_ECOLI PSORT-B swissprot:PHOU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PHOU_ECOLI PSORT2 swissprot:PHOU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PHOU_ECOLI Pfam PF01895 http://pfam.xfam.org/family/PF01895 Phobius swissprot:PHOU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PHOU_ECOLI PhylomeDB P0A9K7 http://phylomedb.org/?seqid=P0A9K7 ProteinModelPortal P0A9K7 http://www.proteinmodelportal.org/query/uniprot/P0A9K7 PubMed 12147514 http://www.ncbi.nlm.nih.gov/pubmed/12147514 PubMed 12471449 http://www.ncbi.nlm.nih.gov/pubmed/12471449 PubMed 1459954 http://www.ncbi.nlm.nih.gov/pubmed/1459954 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17420206 http://www.ncbi.nlm.nih.gov/pubmed/17420206 PubMed 18031348 http://www.ncbi.nlm.nih.gov/pubmed/18031348 PubMed 18248418 http://www.ncbi.nlm.nih.gov/pubmed/18248418 PubMed 19047379 http://www.ncbi.nlm.nih.gov/pubmed/19047379 PubMed 20171928 http://www.ncbi.nlm.nih.gov/pubmed/20171928 PubMed 2993631 http://www.ncbi.nlm.nih.gov/pubmed/2993631 PubMed 3034860 http://www.ncbi.nlm.nih.gov/pubmed/3034860 PubMed 3536855 http://www.ncbi.nlm.nih.gov/pubmed/3536855 PubMed 3881386 http://www.ncbi.nlm.nih.gov/pubmed/3881386 PubMed 6090402 http://www.ncbi.nlm.nih.gov/pubmed/6090402 PubMed 6310121 http://www.ncbi.nlm.nih.gov/pubmed/6310121 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 8226621 http://www.ncbi.nlm.nih.gov/pubmed/8226621 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418180 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418180 RefSeq WP_000377786 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000377786 SMR P0A9K7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9K7 STRING 511145.b3724 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3724&targetmode=cogs STRING COG0704 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0704&targetmode=cogs TIGRFAMs TIGR02135 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02135 UniProtKB PHOU_ECOLI http://www.uniprot.org/uniprot/PHOU_ECOLI UniProtKB-AC P0A9K7 http://www.uniprot.org/uniprot/P0A9K7 charge swissprot:PHOU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PHOU_ECOLI eggNOG COG0704 http://eggnogapi.embl.de/nog_data/html/tree/COG0704 eggNOG ENOG4108UTW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UTW epestfind swissprot:PHOU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PHOU_ECOLI garnier swissprot:PHOU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PHOU_ECOLI helixturnhelix swissprot:PHOU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PHOU_ECOLI hmoment swissprot:PHOU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PHOU_ECOLI iep swissprot:PHOU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PHOU_ECOLI inforesidue swissprot:PHOU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PHOU_ECOLI octanol swissprot:PHOU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PHOU_ECOLI pepcoil swissprot:PHOU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PHOU_ECOLI pepdigest swissprot:PHOU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PHOU_ECOLI pepinfo swissprot:PHOU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PHOU_ECOLI pepnet swissprot:PHOU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PHOU_ECOLI pepstats swissprot:PHOU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PHOU_ECOLI pepwheel swissprot:PHOU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PHOU_ECOLI pepwindow swissprot:PHOU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PHOU_ECOLI sigcleave swissprot:PHOU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PHOU_ECOLI ## Database ID URL or Descriptions # AltName VES_ECOLI Various environmental stresses-induced protein # DEVELOPMENTAL STAGE Expression peaks 6-12 hours after induction. {ECO:0000269|PubMed 11873911}. # EcoGene EG13994 ves # Gene3D 2.60.120.10 -; 1. # HAMAP MF_01591 Ves # INDUCTION Induced by various environmental stresses, including low temperature, osmotic shock and oxygen. Expression is induced more than 10 fold by reducing temperature from 37 to 25 degrees Celsius. {ECO:0000269|PubMed 11873911}. # IntAct P76214 3 # InterPro IPR010282 Uncharacterised_HutD/Ves # InterPro IPR011051 RmlC_Cupin # InterPro IPR014710 RmlC-like_jellyroll # InterPro IPR023482 Uncharacterised_Ves # Organism VES_ECOLI Escherichia coli (strain K12) # PATRIC 32118793 VBIEscCol129921_1814 # PIR F64933 F64933 # Pfam PF05962 HutD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Protein Ves {ECO:0000255|HAMAP-Rule MF_01591} # RefSeq NP_416256 NC_000913.3 # RefSeq WP_001300480 NZ_LN832404.1 # SIMILARITY Belongs to the Ves family. {ECO:0000255|HAMAP- Rule MF_01591}. # SUPFAM SSF51182 SSF51182 # eggNOG COG3758 LUCA # eggNOG ENOG41090B9 Bacteria BLAST swissprot:VES_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:VES_ECOLI BioCyc ECOL316407:JW1731-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1731-MONOMER BioCyc EcoCyc:G6938-MONOMER http://biocyc.org/getid?id=EcoCyc:G6938-MONOMER COG COG3758 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3758 DIP DIP-11778N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11778N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3750 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3750 EcoGene EG13994 http://www.ecogene.org/geneInfo.php?eg_id=EG13994 EnsemblBacteria AAC74812 http://www.ensemblgenomes.org/id/AAC74812 EnsemblBacteria AAC74812 http://www.ensemblgenomes.org/id/AAC74812 EnsemblBacteria BAA15530 http://www.ensemblgenomes.org/id/BAA15530 EnsemblBacteria BAA15530 http://www.ensemblgenomes.org/id/BAA15530 EnsemblBacteria BAA15530 http://www.ensemblgenomes.org/id/BAA15530 EnsemblBacteria b1742 http://www.ensemblgenomes.org/id/b1742 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 2.60.120.10 http://www.cathdb.info/version/latest/superfamily/2.60.120.10 GeneID 946245 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946245 HAMAP MF_01591 http://hamap.expasy.org/unirule/MF_01591 HOGENOM HOG000251894 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000251894&db=HOGENOM6 InParanoid P76214 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76214 IntAct P76214 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76214* InterPro IPR010282 http://www.ebi.ac.uk/interpro/entry/IPR010282 InterPro IPR011051 http://www.ebi.ac.uk/interpro/entry/IPR011051 InterPro IPR014710 http://www.ebi.ac.uk/interpro/entry/IPR014710 InterPro IPR023482 http://www.ebi.ac.uk/interpro/entry/IPR023482 KEGG_Gene ecj:JW1731 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1731 KEGG_Gene eco:b1742 http://www.genome.jp/dbget-bin/www_bget?eco:b1742 KEGG_Orthology KO:K09975 http://www.genome.jp/dbget-bin/www_bget?KO:K09975 OMA ETREICC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ETREICC PSORT swissprot:VES_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:VES_ECOLI PSORT-B swissprot:VES_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:VES_ECOLI PSORT2 swissprot:VES_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:VES_ECOLI Pfam PF05962 http://pfam.xfam.org/family/PF05962 Phobius swissprot:VES_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:VES_ECOLI ProteinModelPortal P76214 http://www.proteinmodelportal.org/query/uniprot/P76214 PubMed 11873911 http://www.ncbi.nlm.nih.gov/pubmed/11873911 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416256 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416256 RefSeq WP_001300480 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300480 SMR P76214 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76214 STRING 511145.b1742 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1742&targetmode=cogs STRING COG3758 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3758&targetmode=cogs SUPFAM SSF51182 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51182 UniProtKB VES_ECOLI http://www.uniprot.org/uniprot/VES_ECOLI UniProtKB-AC P76214 http://www.uniprot.org/uniprot/P76214 charge swissprot:VES_ECOLI http://rest.g-language.org/emboss/charge/swissprot:VES_ECOLI eggNOG COG3758 http://eggnogapi.embl.de/nog_data/html/tree/COG3758 eggNOG ENOG41090B9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41090B9 epestfind swissprot:VES_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:VES_ECOLI garnier swissprot:VES_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:VES_ECOLI helixturnhelix swissprot:VES_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:VES_ECOLI hmoment swissprot:VES_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:VES_ECOLI iep swissprot:VES_ECOLI http://rest.g-language.org/emboss/iep/swissprot:VES_ECOLI inforesidue swissprot:VES_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:VES_ECOLI octanol swissprot:VES_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:VES_ECOLI pepcoil swissprot:VES_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:VES_ECOLI pepdigest swissprot:VES_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:VES_ECOLI pepinfo swissprot:VES_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:VES_ECOLI pepnet swissprot:VES_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:VES_ECOLI pepstats swissprot:VES_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:VES_ECOLI pepwheel swissprot:VES_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:VES_ECOLI pepwindow swissprot:VES_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:VES_ECOLI sigcleave swissprot:VES_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:VES_ECOLI ## Database ID URL or Descriptions # BioGrid 4259865 299 # DOMAIN RHSD_ECOLI Each rhs appears to consist of a highly conserved 141 kDa amino fragment followed by a highly divergent C-terminus. # EcoGene EG10849 rhsD # FUNCTION RHSD_ECOLI Rhs elements have a nonessential function. They may play an important role in the natural ecology of the cell. # GO_process GO:0010438 cellular response to sulfur starvation; IEP:EcoCyc. # GO_process GO:0097264 self proteolysis; IEA:InterPro. # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # INDUCTION Repressed by H-NS, induced by LeuO. Part of the rhsD- ybbC operon. {ECO:0000269|PubMed 19429622}. # IntAct P16919 18 # InterPro IPR001826 RHS # InterPro IPR006530 YD # InterPro IPR022385 Rhs_assc_core # InterPro IPR025479 DUF4329 # InterPro IPR031325 RHS_repeat # Organism RHSD_ECOLI Escherichia coli (strain K12) # PATRIC 32116153 VBIEscCol129921_0518 # PIR H64780 H64780 # PRINTS PR00394 RHSPROTEIN # Pfam PF03527 RHS # Pfam PF05593 RHS_repeat; 6 # Pfam PF14220 DUF4329 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RHSD_ECOLI Protein RhsD # RefSeq NP_415030 NC_000913.3 # RefSeq WP_000014739 NZ_CP014272.1 # SIMILARITY Belongs to the RHS family. {ECO 0000305}. # TIGRFAMs TIGR01643 YD_repeat_2x; 7 # TIGRFAMs TIGR03696 Rhs_assc_core # eggNOG COG3209 LUCA # eggNOG ENOG4105CNA Bacteria BLAST swissprot:RHSD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RHSD_ECOLI BioCyc ECOL316407:JW0486-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0486-MONOMER BioCyc EcoCyc:EG10849-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10849-MONOMER DIP DIP-10702N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10702N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/19.25.7177 http://dx.doi.org/10.1093/nar/19.25.7177 DOI 10.1111/j.1365-2958.1994.tb01074.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb01074.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00108-09 http://dx.doi.org/10.1128/JB.00108-09 EMBL AF044500 http://www.ebi.ac.uk/ena/data/view/AF044500 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL X60999 http://www.ebi.ac.uk/ena/data/view/X60999 EchoBASE EB0842 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0842 EcoGene EG10849 http://www.ecogene.org/geneInfo.php?eg_id=EG10849 EnsemblBacteria AAC73599 http://www.ensemblgenomes.org/id/AAC73599 EnsemblBacteria AAC73599 http://www.ensemblgenomes.org/id/AAC73599 EnsemblBacteria BAE76276 http://www.ensemblgenomes.org/id/BAE76276 EnsemblBacteria BAE76276 http://www.ensemblgenomes.org/id/BAE76276 EnsemblBacteria BAE76276 http://www.ensemblgenomes.org/id/BAE76276 EnsemblBacteria b0497 http://www.ensemblgenomes.org/id/b0497 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0010438 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010438 GO_process GO:0097264 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097264 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 945116 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945116 HOGENOM HOG000225201 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000225201&db=HOGENOM6 InParanoid P16919 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P16919 IntAct P16919 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P16919* InterPro IPR001826 http://www.ebi.ac.uk/interpro/entry/IPR001826 InterPro IPR006530 http://www.ebi.ac.uk/interpro/entry/IPR006530 InterPro IPR022385 http://www.ebi.ac.uk/interpro/entry/IPR022385 InterPro IPR025479 http://www.ebi.ac.uk/interpro/entry/IPR025479 InterPro IPR031325 http://www.ebi.ac.uk/interpro/entry/IPR031325 KEGG_Gene ecj:JW0486 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0486 KEGG_Gene eco:b0497 http://www.genome.jp/dbget-bin/www_bget?eco:b0497 MINT MINT-1244837 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1244837 OMA AVYYGYD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AVYYGYD PRINTS PR00394 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00394 PSORT swissprot:RHSD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RHSD_ECOLI PSORT-B swissprot:RHSD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RHSD_ECOLI PSORT2 swissprot:RHSD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RHSD_ECOLI Pfam PF03527 http://pfam.xfam.org/family/PF03527 Pfam PF05593 http://pfam.xfam.org/family/PF05593 Pfam PF14220 http://pfam.xfam.org/family/PF14220 Phobius swissprot:RHSD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RHSD_ECOLI PhylomeDB P16919 http://phylomedb.org/?seqid=P16919 ProteinModelPortal P16919 http://www.proteinmodelportal.org/query/uniprot/P16919 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1766878 http://www.ncbi.nlm.nih.gov/pubmed/1766878 PubMed 19429622 http://www.ncbi.nlm.nih.gov/pubmed/19429622 PubMed 2403547 http://www.ncbi.nlm.nih.gov/pubmed/2403547 PubMed 2644231 http://www.ncbi.nlm.nih.gov/pubmed/2644231 PubMed 7934896 http://www.ncbi.nlm.nih.gov/pubmed/7934896 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415030 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415030 RefSeq WP_000014739 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000014739 SMR P16919 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P16919 STRING 511145.b0497 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0497&targetmode=cogs TIGRFAMs TIGR01643 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01643 TIGRFAMs TIGR03696 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03696 UniProtKB RHSD_ECOLI http://www.uniprot.org/uniprot/RHSD_ECOLI UniProtKB-AC P16919 http://www.uniprot.org/uniprot/P16919 charge swissprot:RHSD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RHSD_ECOLI eggNOG COG3209 http://eggnogapi.embl.de/nog_data/html/tree/COG3209 eggNOG ENOG4105CNA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CNA epestfind swissprot:RHSD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RHSD_ECOLI garnier swissprot:RHSD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RHSD_ECOLI helixturnhelix swissprot:RHSD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RHSD_ECOLI hmoment swissprot:RHSD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RHSD_ECOLI iep swissprot:RHSD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RHSD_ECOLI inforesidue swissprot:RHSD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RHSD_ECOLI octanol swissprot:RHSD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RHSD_ECOLI pepcoil swissprot:RHSD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RHSD_ECOLI pepdigest swissprot:RHSD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RHSD_ECOLI pepinfo swissprot:RHSD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RHSD_ECOLI pepnet swissprot:RHSD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RHSD_ECOLI pepstats swissprot:RHSD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RHSD_ECOLI pepwheel swissprot:RHSD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RHSD_ECOLI pepwindow swissprot:RHSD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RHSD_ECOLI sigcleave swissprot:RHSD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RHSD_ECOLI ## Database ID URL or Descriptions # AltName RNR_ECOLI Protein VacB # BIOPHYSICOCHEMICAL PROPERTIES RNR_ECOLI Kinetic parameters Vmax=26900 nmol/min/mg enzyme with Poly(A) as substrate {ECO 0000269|PubMed 11948193}; Vmax=4840 nmol/min/mg enzyme with 23S rRNA as substrate {ECO 0000269|PubMed 11948193}; Vmax=2750 nmol/min/mg enzyme with 16S rRNA as substrate {ECO 0000269|PubMed 11948193}; Vmax=290 nmol/min/mg enzyme with 5S rRNA as substrate {ECO 0000269|PubMed 11948193}; Vmax=350 nmol/min/mg enzyme with tRNA as substrate {ECO 0000269|PubMed 11948193}; pH dependence Optimum pH is 7.5-9.5. {ECO 0000269|PubMed 11948193}; Temperature dependence Optimum temperature is 50 degrees Celsius. {ECO 0000269|PubMed 11948193}; # BioGrid 4261892 10 # CATALYTIC ACTIVITY Exonucleolytic cleavage in the 3'- to 5'- direction to yield nucleoside 5'-phosphates. {ECO:0000269|PubMed 11948193}. # COFACTOR RNR_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 11948193}; # ENZYME REGULATION RNR_ECOLI Stimulated by the presence of a monovalent cation. Highly unstable in exponential growth phase. This instability is due to the binding of SsrA/tmRNA and its associated protein SmpB to the C-terminal region of RNase R. In contrast, RNase R becomes stabilized upon entry into stationary phase. The difference in stability between exponential and stationary phase is due to the acetylation of a single lysine residue. {ECO 0000269|PubMed 11948193, ECO 0000269|PubMed 20688916, ECO 0000269|PubMed 21981926}. # EcoGene EG11259 rnr # FUNCTION RNR_ECOLI 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (rRNAs, tRNAs and SsrA/tmRNA). In stationary phase, involved in the post-transcriptional regulation of ompA mRNA stability. Shortens RNA processively to di- and trinucleotides. In vitro, exhibits helicase activity, which is independent of its RNase activity. Required for the expression of virulence genes in enteroinvasive strains of E.coli. {ECO 0000269|PubMed 11948193, ECO 0000269|PubMed 14622421, ECO 0000269|PubMed 16556233, ECO 0000269|PubMed 20023028}. # GO_component GO:0000178 exosome (RNase complex); IBA:GO_Central. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000175 3'-5'-exoribonuclease activity; IDA:EcoCyc. # GO_function GO:0003723 RNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0004540 ribonuclease activity; IMP:EcoliWiki. # GO_function GO:0008859 exoribonuclease II activity; IEA:UniProtKB-HAMAP. # GO_function GO:0008997 ribonuclease R activity; IDA:EcoCyc. # GO_function GO:0016896 exoribonuclease activity, producing 5'-phosphomonoesters; IDA:EcoliWiki. # GO_function GO:0034458 3'-5' RNA helicase activity; IDA:EcoCyc. # GO_process GO:0006364 rRNA processing; IBA:GO_Central. # GO_process GO:0006402 mRNA catabolic process; IMP:EcoCyc. # GO_process GO:0009405 pathogenesis; IEA:UniProtKB-KW. # GO_process GO:0009409 response to cold; IEP:EcoCyc. # GO_process GO:0034470 ncRNA processing; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0004386 helicase activity # GOslim_function GO:0004518 nuclease activity # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # HAMAP MF_01895 RNase_R # INDUCTION RNR_ECOLI Induced seven- to eightfold by cold shock. Induction is mainly a result of the stabilization of the rnr transcripts. Also induced at stationary phase. {ECO 0000269|PubMed 14527658, ECO 0000269|PubMed 14622421, ECO 0000269|PubMed 16556233}. # IntAct P21499 60 # InterPro IPR003029 S1_domain # InterPro IPR004476 RNase_II/RNase_R # InterPro IPR011129 Cold_shock_prot # InterPro IPR011805 RNase_R # InterPro IPR012340 NA-bd_OB-fold # InterPro IPR013223 RNase_B_OB_dom # InterPro IPR013668 RNase_R_HTH_12 # InterPro IPR022966 RNase_II/R_CS # InterPro IPR022967 S1_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # KEGG_Pathway ko03018 RNA degradation # Organism RNR_ECOLI Escherichia coli (strain K12) # PATRIC 32123931 VBIEscCol129921_4310 # PIR S56404 S56404 # PROSITE PS01175 RIBONUCLEASE_II # PROSITE PS50126 S1 # PTM RNR_ECOLI Acetylated at Lys-544 by Pka during exponential growth phase. Acetylation alters RNase R structure and enhances binding of SsrA/tmRNA and SmpB, leading to instability and degradation of RNase R. Not acetylated and stable in stationary phase cells. {ECO 0000269|PubMed 18723842, ECO 0000269|PubMed 21981926, ECO 0000269|PubMed 22124017}. # Pfam PF00575 S1 # Pfam PF08206 OB_RNB; 2 # Pfam PF08461 HTH_12 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RNR_ECOLI Ribonuclease R # RefSeq NP_418600 NC_000913.3 # RefSeq WP_000076332 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97075.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the RNR ribonuclease family. RNase R subfamily. {ECO 0000305}. # SIMILARITY Contains 1 S1 motif domain. {ECO 0000305}. # SMART SM00316 S1 # SMART SM00357 CSP # SUBCELLULAR LOCATION RNR_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Monomer. {ECO:0000269|PubMed 11948193}. # SUPFAM SSF50249 SSF50249; 4 # TIGRFAMs TIGR00358 3_prime_RNase # TIGRFAMs TIGR02063 RNase_R # eggNOG COG0557 LUCA # eggNOG ENOG4105C40 Bacteria BLAST swissprot:RNR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RNR_ECOLI BioCyc ECOL316407:JW5741-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5741-MONOMER BioCyc EcoCyc:EG11259-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11259-MONOMER BioCyc MetaCyc:EG11259-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11259-MONOMER COG COG0557 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0557 DIP DIP-10733N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10733N DOI 10.1016/S0923-2508(03)00167-0 http://dx.doi.org/10.1016/S0923-2508(03)00167-0 DOI 10.1016/j.molcel.2011.06.037 http://dx.doi.org/10.1016/j.molcel.2011.06.037 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2003.03766.x http://dx.doi.org/10.1046/j.1365-2958.2003.03766.x DOI 10.1074/jbc.273.23.14077 http://dx.doi.org/10.1074/jbc.273.23.14077 DOI 10.1074/jbc.C110.168641 http://dx.doi.org/10.1074/jbc.C110.168641 DOI 10.1074/jbc.M202942200 http://dx.doi.org/10.1074/jbc.M202942200 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1111/j.1365-2958.2006.05092.x http://dx.doi.org/10.1111/j.1365-2958.2006.05092.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.01368-09 http://dx.doi.org/10.1128/JB.01368-09 DOI 10.1261/rna.030213.111 http://dx.doi.org/10.1261/rna.030213.111 EC_number EC:3.1.13.1 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.13.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J04199 http://www.ebi.ac.uk/ena/data/view/J04199 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 3.1.13.1 http://enzyme.expasy.org/EC/3.1.13.1 EchoBASE EB1239 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1239 EcoGene EG11259 http://www.ecogene.org/geneInfo.php?eg_id=EG11259 EnsemblBacteria AAC77136 http://www.ensemblgenomes.org/id/AAC77136 EnsemblBacteria AAC77136 http://www.ensemblgenomes.org/id/AAC77136 EnsemblBacteria BAE78180 http://www.ensemblgenomes.org/id/BAE78180 EnsemblBacteria BAE78180 http://www.ensemblgenomes.org/id/BAE78180 EnsemblBacteria BAE78180 http://www.ensemblgenomes.org/id/BAE78180 EnsemblBacteria b4179 http://www.ensemblgenomes.org/id/b4179 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0000178 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000178 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000175 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000175 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0004540 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004540 GO_function GO:0008859 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008859 GO_function GO:0008997 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008997 GO_function GO:0016896 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016896 GO_function GO:0034458 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034458 GO_process GO:0006364 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006364 GO_process GO:0006402 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006402 GO_process GO:0009405 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009405 GO_process GO:0009409 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009409 GO_process GO:0034470 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034470 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0004386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004386 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 GeneID 948692 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948692 HAMAP MF_01895 http://hamap.expasy.org/unirule/MF_01895 HOGENOM HOG000071120 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000071120&db=HOGENOM6 InParanoid P21499 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P21499 IntAct P21499 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P21499* IntEnz 3.1.13.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.13.1 InterPro IPR003029 http://www.ebi.ac.uk/interpro/entry/IPR003029 InterPro IPR004476 http://www.ebi.ac.uk/interpro/entry/IPR004476 InterPro IPR011129 http://www.ebi.ac.uk/interpro/entry/IPR011129 InterPro IPR011805 http://www.ebi.ac.uk/interpro/entry/IPR011805 InterPro IPR012340 http://www.ebi.ac.uk/interpro/entry/IPR012340 InterPro IPR013223 http://www.ebi.ac.uk/interpro/entry/IPR013223 InterPro IPR013668 http://www.ebi.ac.uk/interpro/entry/IPR013668 InterPro IPR022966 http://www.ebi.ac.uk/interpro/entry/IPR022966 InterPro IPR022967 http://www.ebi.ac.uk/interpro/entry/IPR022967 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW5741 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5741 KEGG_Gene eco:b4179 http://www.genome.jp/dbget-bin/www_bget?eco:b4179 KEGG_Orthology KO:K12573 http://www.genome.jp/dbget-bin/www_bget?KO:K12573 KEGG_Pathway ko03018 http://www.genome.jp/kegg-bin/show_pathway?ko03018 OMA ERMTYTN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ERMTYTN PROSITE PS01175 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01175 PROSITE PS50126 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50126 PSORT swissprot:RNR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RNR_ECOLI PSORT-B swissprot:RNR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RNR_ECOLI PSORT2 swissprot:RNR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RNR_ECOLI Pfam PF00575 http://pfam.xfam.org/family/PF00575 Pfam PF08206 http://pfam.xfam.org/family/PF08206 Pfam PF08461 http://pfam.xfam.org/family/PF08461 Phobius swissprot:RNR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RNR_ECOLI PhylomeDB P21499 http://phylomedb.org/?seqid=P21499 ProteinModelPortal P21499 http://www.proteinmodelportal.org/query/uniprot/P21499 PubMed 11948193 http://www.ncbi.nlm.nih.gov/pubmed/11948193 PubMed 1400189 http://www.ncbi.nlm.nih.gov/pubmed/1400189 PubMed 14527658 http://www.ncbi.nlm.nih.gov/pubmed/14527658 PubMed 14622421 http://www.ncbi.nlm.nih.gov/pubmed/14622421 PubMed 16556233 http://www.ncbi.nlm.nih.gov/pubmed/16556233 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 20023028 http://www.ncbi.nlm.nih.gov/pubmed/20023028 PubMed 20688916 http://www.ncbi.nlm.nih.gov/pubmed/20688916 PubMed 21981926 http://www.ncbi.nlm.nih.gov/pubmed/21981926 PubMed 22124017 http://www.ncbi.nlm.nih.gov/pubmed/22124017 PubMed 3058695 http://www.ncbi.nlm.nih.gov/pubmed/3058695 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9603904 http://www.ncbi.nlm.nih.gov/pubmed/9603904 RefSeq NP_418600 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418600 RefSeq WP_000076332 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000076332 SMART SM00316 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00316 SMART SM00357 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00357 SMR P21499 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P21499 STRING 511145.b4179 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4179&targetmode=cogs STRING COG0557 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0557&targetmode=cogs SUPFAM SSF50249 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50249 TIGRFAMs TIGR00358 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00358 TIGRFAMs TIGR02063 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02063 UniProtKB RNR_ECOLI http://www.uniprot.org/uniprot/RNR_ECOLI UniProtKB-AC P21499 http://www.uniprot.org/uniprot/P21499 charge swissprot:RNR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RNR_ECOLI eggNOG COG0557 http://eggnogapi.embl.de/nog_data/html/tree/COG0557 eggNOG ENOG4105C40 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C40 epestfind swissprot:RNR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RNR_ECOLI garnier swissprot:RNR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RNR_ECOLI helixturnhelix swissprot:RNR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RNR_ECOLI hmoment swissprot:RNR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RNR_ECOLI iep swissprot:RNR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RNR_ECOLI inforesidue swissprot:RNR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RNR_ECOLI octanol swissprot:RNR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RNR_ECOLI pepcoil swissprot:RNR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RNR_ECOLI pepdigest swissprot:RNR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RNR_ECOLI pepinfo swissprot:RNR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RNR_ECOLI pepnet swissprot:RNR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RNR_ECOLI pepstats swissprot:RNR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RNR_ECOLI pepwheel swissprot:RNR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RNR_ECOLI pepwindow swissprot:RNR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RNR_ECOLI sigcleave swissprot:RNR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RNR_ECOLI ## Database ID URL or Descriptions # BioGrid 4261152 226 # CDD cd06261 TM_PBP2 # EcoGene EG10675 oppB # FUNCTION OPPB_ECOLI Part of the binding-protein-dependent transport system for oligopeptides; probably responsible for the translocation of the substrate across the membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0015421 oligopeptide-transporting ATPase activity; IMP:EcoCyc. # GO_function GO:0042937 tripeptide transporter activity; IMP:EcoCyc. # GO_process GO:0015031 protein transport; IEA:UniProtKB-KW. # GO_process GO:0042939 tripeptide transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # Gene3D 1.10.3720.10 -; 1. # InterPro IPR000515 MetI-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00439 Oligopeptide transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism OPPB_ECOLI Escherichia coli (strain K12) # PATRIC 32117748 VBIEscCol129921_1294 # PIR G64871 B36263 # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName OPPB_ECOLI Oligopeptide transport system permease protein OppB # RefSeq NP_415760 NC_000913.3 # RefSeq WP_000911112 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION OPPB_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF161098 SSF161098 # TCDB 3.A.1.5.41 the atp-binding cassette (abc) superfamily # eggNOG COG0601 LUCA # eggNOG ENOG4105CJM Bacteria BLAST swissprot:OPPB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:OPPB_ECOLI BioCyc ECOL316407:JW1236-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1236-MONOMER BioCyc EcoCyc:OPPB-MONOMER http://biocyc.org/getid?id=EcoCyc:OPPB-MONOMER BioCyc MetaCyc:OPPB-MONOMER http://biocyc.org/getid?id=MetaCyc:OPPB-MONOMER COG COG0601 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0601 DIP DIP-48074N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48074N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J05433 http://www.ebi.ac.uk/ena/data/view/J05433 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0669 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0669 EcoGene EG10675 http://www.ecogene.org/geneInfo.php?eg_id=EG10675 EnsemblBacteria AAC74326 http://www.ensemblgenomes.org/id/AAC74326 EnsemblBacteria AAC74326 http://www.ensemblgenomes.org/id/AAC74326 EnsemblBacteria BAA14776 http://www.ensemblgenomes.org/id/BAA14776 EnsemblBacteria BAA14776 http://www.ensemblgenomes.org/id/BAA14776 EnsemblBacteria BAA14776 http://www.ensemblgenomes.org/id/BAA14776 EnsemblBacteria b1244 http://www.ensemblgenomes.org/id/b1244 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015421 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015421 GO_function GO:0042937 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042937 GO_process GO:0015031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031 GO_process GO:0042939 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042939 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 945823 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945823 HOGENOM HOG000170249 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000170249&db=HOGENOM6 InParanoid P0AFH2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFH2 InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1236 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1236 KEGG_Gene eco:b1244 http://www.genome.jp/dbget-bin/www_bget?eco:b1244 KEGG_Orthology KO:K15581 http://www.genome.jp/dbget-bin/www_bget?KO:K15581 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA ANSFIFI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ANSFIFI PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:OPPB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:OPPB_ECOLI PSORT-B swissprot:OPPB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:OPPB_ECOLI PSORT2 swissprot:OPPB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:OPPB_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Phobius swissprot:OPPB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:OPPB_ECOLI PhylomeDB P0AFH2 http://phylomedb.org/?seqid=P0AFH2 ProteinModelPortal P0AFH2 http://www.proteinmodelportal.org/query/uniprot/P0AFH2 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2187863 http://www.ncbi.nlm.nih.gov/pubmed/2187863 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415760 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415760 RefSeq WP_000911112 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000911112 STRING 511145.b1244 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1244&targetmode=cogs STRING COG0601 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0601&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.5.41 http://www.tcdb.org/search/result.php?tc=3.A.1.5.41 UniProtKB OPPB_ECOLI http://www.uniprot.org/uniprot/OPPB_ECOLI UniProtKB-AC P0AFH2 http://www.uniprot.org/uniprot/P0AFH2 charge swissprot:OPPB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:OPPB_ECOLI eggNOG COG0601 http://eggnogapi.embl.de/nog_data/html/tree/COG0601 eggNOG ENOG4105CJM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CJM epestfind swissprot:OPPB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:OPPB_ECOLI garnier swissprot:OPPB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:OPPB_ECOLI helixturnhelix swissprot:OPPB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:OPPB_ECOLI hmoment swissprot:OPPB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:OPPB_ECOLI iep swissprot:OPPB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:OPPB_ECOLI inforesidue swissprot:OPPB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:OPPB_ECOLI octanol swissprot:OPPB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:OPPB_ECOLI pepcoil swissprot:OPPB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:OPPB_ECOLI pepdigest swissprot:OPPB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:OPPB_ECOLI pepinfo swissprot:OPPB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:OPPB_ECOLI pepnet swissprot:OPPB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:OPPB_ECOLI pepstats swissprot:OPPB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:OPPB_ECOLI pepwheel swissprot:OPPB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:OPPB_ECOLI pepwindow swissprot:OPPB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:OPPB_ECOLI sigcleave swissprot:OPPB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:OPPB_ECOLI ## Database ID URL or Descriptions # AltName COBS_ECOLI Cobalamin synthase # AltName COBS_ECOLI Cobalamin-5'-phosphate synthase # BioGrid 4260409 9 # CATALYTIC ACTIVITY COBS_ECOLI Adenosylcobinamide-GDP + alpha-ribazole 5'- phosphate = GMP + adenosylcobalamin 5'-phosphate. # CATALYTIC ACTIVITY COBS_ECOLI Adenosylcobinamide-GDP + alpha-ribazole = GMP + adenosylcobalamin. # COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI 18420; Evidence={ECO:0000250}; # EcoGene EG12150 cobS # FUNCTION COBS_ECOLI Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate (By similarity). {ECO 0000250}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0008818 cobalamin 5'-phosphate synthase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0051073 adenosylcobinamide-GDP ribazoletransferase activity; IEA:UniProtKB-HAMAP. # GO_process GO:0009236 cobalamin biosynthetic process; IMP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # HAMAP MF_00719 CobS # INDUCTION COBS_ECOLI By cobinamide. # IntAct P36561 5 # InterPro IPR003805 CobS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00860 Porphyrin and chlorophyll metabolism # Organism COBS_ECOLI Escherichia coli (strain K12) # PATHWAY Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide step 7/7. # PATRIC 32119315 VBIEscCol129921_2067 # PIR G64963 G64963 # Pfam PF02654 CobS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName COBS_ECOLI Adenosylcobinamide-GDP ribazoletransferase # RefSeq NP_416496 NC_000913.3 # RefSeq WP_001326708 NZ_LN832404.1 # SIMILARITY Belongs to the CobS family. {ECO 0000305}. # SUBCELLULAR LOCATION COBS_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # TIGRFAMs TIGR00317 cobS # UniPathway UPA00148 UER00238 # eggNOG COG0368 LUCA # eggNOG ENOG4108UHF Bacteria BLAST swissprot:COBS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:COBS_ECOLI BioCyc ECOL316407:JW1970-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1970-MONOMER BioCyc EcoCyc:COBS-MONOMER http://biocyc.org/getid?id=EcoCyc:COBS-MONOMER BioCyc MetaCyc:COBS-MONOMER http://biocyc.org/getid?id=MetaCyc:COBS-MONOMER COG COG0368 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0368 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.8.26 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.8.26 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L25054 http://www.ebi.ac.uk/ena/data/view/L25054 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U33333 http://www.ebi.ac.uk/ena/data/view/U33333 ENZYME 2.7.8.26 http://enzyme.expasy.org/EC/2.7.8.26 EchoBASE EB2070 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2070 EcoGene EG12150 http://www.ecogene.org/geneInfo.php?eg_id=EG12150 EnsemblBacteria AAC75053 http://www.ensemblgenomes.org/id/AAC75053 EnsemblBacteria AAC75053 http://www.ensemblgenomes.org/id/AAC75053 EnsemblBacteria BAA15809 http://www.ensemblgenomes.org/id/BAA15809 EnsemblBacteria BAA15809 http://www.ensemblgenomes.org/id/BAA15809 EnsemblBacteria BAA15809 http://www.ensemblgenomes.org/id/BAA15809 EnsemblBacteria b1992 http://www.ensemblgenomes.org/id/b1992 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008818 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008818 GO_function GO:0051073 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051073 GO_process GO:0009236 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009236 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 946520 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946520 HAMAP MF_00719 http://hamap.expasy.org/unirule/MF_00719 HOGENOM HOG000228087 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000228087&db=HOGENOM6 InParanoid P36561 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P36561 IntAct P36561 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P36561* IntEnz 2.7.8.26 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.8.26 InterPro IPR003805 http://www.ebi.ac.uk/interpro/entry/IPR003805 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1970 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1970 KEGG_Gene eco:b1992 http://www.genome.jp/dbget-bin/www_bget?eco:b1992 KEGG_Orthology KO:K02233 http://www.genome.jp/dbget-bin/www_bget?KO:K02233 KEGG_Pathway ko00860 http://www.genome.jp/kegg-bin/show_pathway?ko00860 KEGG_Reaction rn:R05223 http://www.genome.jp/dbget-bin/www_bget?rn:R05223 OMA GAWNWLV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GAWNWLV PSORT swissprot:COBS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:COBS_ECOLI PSORT-B swissprot:COBS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:COBS_ECOLI PSORT2 swissprot:COBS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:COBS_ECOLI Pfam PF02654 http://pfam.xfam.org/family/PF02654 Phobius swissprot:COBS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:COBS_ECOLI PhylomeDB P36561 http://phylomedb.org/?seqid=P36561 ProteinModelPortal P36561 http://www.proteinmodelportal.org/query/uniprot/P36561 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7592411 http://www.ncbi.nlm.nih.gov/pubmed/7592411 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416496 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416496 RefSeq WP_001326708 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001326708 STRING 511145.b1992 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1992&targetmode=cogs STRING COG0368 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0368&targetmode=cogs TIGRFAMs TIGR00317 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00317 UniProtKB COBS_ECOLI http://www.uniprot.org/uniprot/COBS_ECOLI UniProtKB-AC P36561 http://www.uniprot.org/uniprot/P36561 charge swissprot:COBS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:COBS_ECOLI eggNOG COG0368 http://eggnogapi.embl.de/nog_data/html/tree/COG0368 eggNOG ENOG4108UHF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UHF epestfind swissprot:COBS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:COBS_ECOLI garnier swissprot:COBS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:COBS_ECOLI helixturnhelix swissprot:COBS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:COBS_ECOLI hmoment swissprot:COBS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:COBS_ECOLI iep swissprot:COBS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:COBS_ECOLI inforesidue swissprot:COBS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:COBS_ECOLI octanol swissprot:COBS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:COBS_ECOLI pepcoil swissprot:COBS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:COBS_ECOLI pepdigest swissprot:COBS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:COBS_ECOLI pepinfo swissprot:COBS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:COBS_ECOLI pepnet swissprot:COBS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:COBS_ECOLI pepstats swissprot:COBS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:COBS_ECOLI pepwheel swissprot:COBS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:COBS_ECOLI pepwindow swissprot:COBS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:COBS_ECOLI sigcleave swissprot:COBS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:COBS_ECOLI ## Database ID URL or Descriptions # BioGrid 4259668 224 # EcoGene EG12376 yfeH # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GOslim_component GO:0005886 plasma membrane # InterPro IPR016833 Put_Na-Bile_cotransptr # KEGG_Brite ko02001 Solute carrier family # Organism YFEH_ECOLI Escherichia coli (strain K12) # PANTHER PTHR18640 PTHR18640 # PATRIC 32120201 VBIEscCol129921_2503 # PIR A65015 A65015 # PIRSF PIRSF026166 UCP026166 # Pfam PF13593 SBF_like # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFEH_ECOLI Uncharacterized protein YfeH # RefSeq NP_416905 NC_000913.3 # RefSeq WP_000765610 NZ_LN832404.1 # TCDB 2.A.28.3:the bile acid na(+) symporter (bass) family # eggNOG COG0385 LUCA # eggNOG ENOG4105DHU Bacteria BLAST swissprot:YFEH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFEH_ECOLI BioCyc ECOL316407:JW5876-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5876-MONOMER BioCyc EcoCyc:EG12376-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12376-MONOMER COG COG0385 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0385 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M24278 http://www.ebi.ac.uk/ena/data/view/M24278 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2279 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2279 EcoGene EG12376 http://www.ecogene.org/geneInfo.php?eg_id=EG12376 EnsemblBacteria AAC75463 http://www.ensemblgenomes.org/id/AAC75463 EnsemblBacteria AAC75463 http://www.ensemblgenomes.org/id/AAC75463 EnsemblBacteria BAA16281 http://www.ensemblgenomes.org/id/BAA16281 EnsemblBacteria BAA16281 http://www.ensemblgenomes.org/id/BAA16281 EnsemblBacteria BAA16281 http://www.ensemblgenomes.org/id/BAA16281 EnsemblBacteria b2410 http://www.ensemblgenomes.org/id/b2410 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 946874 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946874 HOGENOM HOG000265419 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000265419&db=HOGENOM6 InParanoid P39836 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39836 InterPro IPR016833 http://www.ebi.ac.uk/interpro/entry/IPR016833 KEGG_Brite ko02001 http://www.genome.jp/dbget-bin/www_bget?ko02001 KEGG_Gene ecj:JW5876 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5876 KEGG_Gene eco:b2410 http://www.genome.jp/dbget-bin/www_bget?eco:b2410 KEGG_Orthology KO:K14347 http://www.genome.jp/dbget-bin/www_bget?KO:K14347 OMA NTYMARW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NTYMARW PANTHER PTHR18640 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18640 PSORT swissprot:YFEH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFEH_ECOLI PSORT-B swissprot:YFEH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFEH_ECOLI PSORT2 swissprot:YFEH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFEH_ECOLI Pfam PF13593 http://pfam.xfam.org/family/PF13593 Phobius swissprot:YFEH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFEH_ECOLI PhylomeDB P39836 http://phylomedb.org/?seqid=P39836 ProteinModelPortal P39836 http://www.proteinmodelportal.org/query/uniprot/P39836 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416905 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416905 RefSeq WP_000765610 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000765610 STRING 511145.b2410 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2410&targetmode=cogs STRING COG0385 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0385&targetmode=cogs TCDB 2.A.28.3 http://www.tcdb.org/search/result.php?tc=2.A.28.3 UniProtKB YFEH_ECOLI http://www.uniprot.org/uniprot/YFEH_ECOLI UniProtKB-AC P39836 http://www.uniprot.org/uniprot/P39836 charge swissprot:YFEH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFEH_ECOLI eggNOG COG0385 http://eggnogapi.embl.de/nog_data/html/tree/COG0385 eggNOG ENOG4105DHU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DHU epestfind swissprot:YFEH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFEH_ECOLI garnier swissprot:YFEH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFEH_ECOLI helixturnhelix swissprot:YFEH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFEH_ECOLI hmoment swissprot:YFEH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFEH_ECOLI iep swissprot:YFEH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFEH_ECOLI inforesidue swissprot:YFEH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFEH_ECOLI octanol swissprot:YFEH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFEH_ECOLI pepcoil swissprot:YFEH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFEH_ECOLI pepdigest swissprot:YFEH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFEH_ECOLI pepinfo swissprot:YFEH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFEH_ECOLI pepnet swissprot:YFEH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFEH_ECOLI pepstats swissprot:YFEH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFEH_ECOLI pepwheel swissprot:YFEH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFEH_ECOLI pepwindow swissprot:YFEH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFEH_ECOLI sigcleave swissprot:YFEH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFEH_ECOLI ## Database ID URL or Descriptions # AltName 2-keto-3-deoxy-D-glucarate aldolase {ECO 0000303|Ref.5} # AltName GARL_ECOLI 2-dehydro-3-deoxy-D-glucarate aldolase # AltName GARL_ECOLI 5-dehydro-4-deoxy-D-glucarate aldolase # AltName GARL_ECOLI Alpha-keto-beta-deoxy-D-glucarate aldolase # BIOPHYSICOCHEMICAL PROPERTIES GARL_ECOLI Kinetic parameters KM=65 uM for 5-keto-4-deoxy-D-glucarate {ECO 0000269|PubMed 9772162}; pH dependence Optimum pH is 7.4-8.6. Stable from pH 6 to 7.5. {ECO 0000269|Ref.5}; # BRENDA 4.1.2.20 2026 # BioGrid 4259487 5 # CATALYTIC ACTIVITY 2-dehydro-3-deoxy-D-glucarate = pyruvate + tartronate semialdehyde. {ECO:0000269|PubMed 9772162, ECO:0000269|Ref.5}. # CATALYTIC ACTIVITY 5-dehydro-4-deoxy-D-glucarate = pyruvate + tartronate semialdehyde. {ECO:0000269|PubMed 9772162, ECO:0000269|Ref.5}. # CAUTION Was wrongly named 2-dehydro-3-deoxygalactarate aldolase (DDG aldolase or DDGA) in PubMed:10921867. 2-dehydro-3- deoxygalactarate is the enantiomer of 5-dehydro-4-deoxy-D- glucarate, but is not an isomer obtained in the degradation pathway of D-glucarate/galactarate and the enzyme has not been shown to be active on it. {ECO 0000305}. # COFACTOR GARL_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|Ref.5}; Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000269|Ref.5}; Name=Fe(2+); Xref=ChEBI CHEBI 29033; Evidence={ECO 0000269|Ref.5}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|Ref.5}; Note=Binds 1 Mg(2+) ion per subunit. Can also use, although less efficiently, Co(2+), Fe(2+) and Mn(2+). {ECO 0000269|Ref.5}; # ENZYME REGULATION Inhibited by acetate, chloride and bromide ions, nitrate, fluoride, cyanide, EDTA and pyrophosphate. {ECO 0000269|Ref.5}. # EcoGene EG10016 garL # FUNCTION GARL_ECOLI Catalyzes the reversible retro-aldol cleavage of both 5- keto-4-deoxy-D-glucarate and 2-keto-3-deoxy-D-glucarate to pyruvate and tartronic semialdehyde. {ECO 0000269|PubMed 9772162, ECO 0000269|Ref.5}. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008672 2-dehydro-3-deoxyglucarate aldolase activity; IDA:EcoliWiki. # GO_function GO:0016830 carbon-carbon lyase activity; IDA:EcoliWiki. # GO_process GO:0019394 glucarate catabolic process; IDA:EcoliWiki. # GO_process GO:0042838 D-glucarate catabolic process; IDA:EcoCyc. # GO_process GO:0046392 galactarate catabolic process; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.60 -; 1. # HAMAP MF_01291 KDGluc_aldolase # INDUCTION Induced by D-galactarate, D-glucarate and D-glycerate. {ECO:0000269|PubMed 10762278}. # IntAct P23522 9 # InterPro IPR005000 Aldolase/citrate-lyase_domain # InterPro IPR015813 Pyrv/PenolPyrv_Kinase-like_dom # InterPro IPR017648 GarL # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00053 Ascorbate and aldarate metabolism # MISCELLANEOUS GARL_ECOLI The catalytic mechanism was originally thought to use a phosphate as the catalytic acid, but this was subsequently disputed (PubMed 15996099, PubMed 17881002 and PubMed 18754683). {ECO 0000305|PubMed 10921867}. # Organism GARL_ECOLI Escherichia coli (strain K12) # PATHWAY Carbohydrate acid metabolism; galactarate degradation; D- glycerate from galactarate: step 2/3. {ECO 0000269|PubMed:9772162}. # PATRIC 32121666 VBIEscCol129921_3219 # PDB 1DXE X-ray; 1.80 A; A/B=1-256 # PDB 1DXF X-ray; 2.60 A; A/B=1-256 # PIR B65102 B65102 # Pfam PF03328 HpcH_HpaI # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 5-keto-4-deoxy-D-glucarate aldolase {ECO:0000303|PubMed 9772162} # RefSeq NP_417595 NC_000913.3 # RefSeq WP_001058209 NZ_LN832404.1 # SIMILARITY Belongs to the HpcH/HpaI aldolase family. KDGluc aldolase subfamily. {ECO 0000305}. # SUBUNIT Homohexamer; trimer of dimers. {ECO:0000269|PubMed 10921867}. # SUPFAM SSF51621 SSF51621 # TIGRFAMs TIGR03239 GarL # UniPathway UPA00565 UER00630 # eggNOG COG3836 LUCA # eggNOG ENOG4105CNV Bacteria BLAST swissprot:GARL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GARL_ECOLI BioCyc ECOL316407:JW3095-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3095-MONOMER BioCyc EcoCyc:KDGALDOL-MONOMER http://biocyc.org/getid?id=EcoCyc:KDGALDOL-MONOMER BioCyc MetaCyc:KDGALDOL-MONOMER http://biocyc.org/getid?id=MetaCyc:KDGALDOL-MONOMER COG COG3836 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3836 DIP DIP-9740N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9740N DOI 10.1021/bi981124f http://dx.doi.org/10.1021/bi981124f DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/emboj/19.15.3849 http://dx.doi.org/10.1093/emboj/19.15.3849 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.9.2672-2674.2000 http://dx.doi.org/10.1128/JB.182.9.2672-2674.2000 EC_number EC:4.1.2.20 {ECO:0000269|PubMed:9772162, ECO:0000269|Ref.5} http://www.genome.jp/dbget-bin/www_bget?EC:4.1.2.20 {ECO:0000269|PubMed:9772162, ECO:0000269|Ref.5} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D90212 http://www.ebi.ac.uk/ena/data/view/D90212 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 4.1.2.20 {ECO:0000269|PubMed:9772162, ECO:0000269|Ref.5} http://enzyme.expasy.org/EC/4.1.2.20 {ECO:0000269|PubMed:9772162, ECO:0000269|Ref.5} EchoBASE EB0016 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0016 EcoGene EG10016 http://www.ecogene.org/geneInfo.php?eg_id=EG10016 EnsemblBacteria AAC76160 http://www.ensemblgenomes.org/id/AAC76160 EnsemblBacteria AAC76160 http://www.ensemblgenomes.org/id/AAC76160 EnsemblBacteria BAE77173 http://www.ensemblgenomes.org/id/BAE77173 EnsemblBacteria BAE77173 http://www.ensemblgenomes.org/id/BAE77173 EnsemblBacteria BAE77173 http://www.ensemblgenomes.org/id/BAE77173 EnsemblBacteria b3126 http://www.ensemblgenomes.org/id/b3126 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0008672 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008672 GO_function GO:0016830 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016830 GO_process GO:0019394 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019394 GO_process GO:0042838 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042838 GO_process GO:0046392 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046392 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.60 http://www.cathdb.info/version/latest/superfamily/3.20.20.60 GeneID 947630 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947630 HAMAP MF_01291 http://hamap.expasy.org/unirule/MF_01291 HOGENOM HOG000179750 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000179750&db=HOGENOM6 InParanoid P23522 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23522 IntAct P23522 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P23522* IntEnz 4.1.2.20 {ECO:0000269|PubMed:9772162, ECO:0000269|Ref.5} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.2.20 {ECO:0000269|PubMed:9772162, ECO:0000269|Ref.5} InterPro IPR005000 http://www.ebi.ac.uk/interpro/entry/IPR005000 InterPro IPR015813 http://www.ebi.ac.uk/interpro/entry/IPR015813 InterPro IPR017648 http://www.ebi.ac.uk/interpro/entry/IPR017648 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3095 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3095 KEGG_Gene eco:b3126 http://www.genome.jp/dbget-bin/www_bget?eco:b3126 KEGG_Orthology KO:K01630 http://www.genome.jp/dbget-bin/www_bget?KO:K01630 KEGG_Pathway ko00053 http://www.genome.jp/kegg-bin/show_pathway?ko00053 KEGG_Reaction rn:R02754 http://www.genome.jp/dbget-bin/www_bget?rn:R02754 KEGG_Reaction rn:R03277 http://www.genome.jp/dbget-bin/www_bget?rn:R03277 OMA HAPNDIT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HAPNDIT PDB 1DXE http://www.ebi.ac.uk/pdbe-srv/view/entry/1DXE PDB 1DXF http://www.ebi.ac.uk/pdbe-srv/view/entry/1DXF PDBsum 1DXE http://www.ebi.ac.uk/pdbsum/1DXE PDBsum 1DXF http://www.ebi.ac.uk/pdbsum/1DXF PSORT swissprot:GARL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GARL_ECOLI PSORT-B swissprot:GARL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GARL_ECOLI PSORT2 swissprot:GARL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GARL_ECOLI Pfam PF03328 http://pfam.xfam.org/family/PF03328 Phobius swissprot:GARL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GARL_ECOLI PhylomeDB P23522 http://phylomedb.org/?seqid=P23522 ProteinModelPortal P23522 http://www.proteinmodelportal.org/query/uniprot/P23522 PubMed 10762278 http://www.ncbi.nlm.nih.gov/pubmed/10762278 PubMed 10921867 http://www.ncbi.nlm.nih.gov/pubmed/10921867 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1705543 http://www.ncbi.nlm.nih.gov/pubmed/1705543 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9772162 http://www.ncbi.nlm.nih.gov/pubmed/9772162 RefSeq NP_417595 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417595 RefSeq WP_001058209 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001058209 SMR P23522 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P23522 STRING 511145.b3126 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3126&targetmode=cogs STRING COG3836 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3836&targetmode=cogs SUPFAM SSF51621 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51621 TIGRFAMs TIGR03239 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03239 UniProtKB GARL_ECOLI http://www.uniprot.org/uniprot/GARL_ECOLI UniProtKB-AC P23522 http://www.uniprot.org/uniprot/P23522 charge swissprot:GARL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GARL_ECOLI eggNOG COG3836 http://eggnogapi.embl.de/nog_data/html/tree/COG3836 eggNOG ENOG4105CNV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CNV epestfind swissprot:GARL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GARL_ECOLI garnier swissprot:GARL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GARL_ECOLI helixturnhelix swissprot:GARL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GARL_ECOLI hmoment swissprot:GARL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GARL_ECOLI iep swissprot:GARL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GARL_ECOLI inforesidue swissprot:GARL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GARL_ECOLI octanol swissprot:GARL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GARL_ECOLI pepcoil swissprot:GARL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GARL_ECOLI pepdigest swissprot:GARL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GARL_ECOLI pepinfo swissprot:GARL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GARL_ECOLI pepnet swissprot:GARL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GARL_ECOLI pepstats swissprot:GARL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GARL_ECOLI pepwheel swissprot:GARL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GARL_ECOLI pepwindow swissprot:GARL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GARL_ECOLI sigcleave swissprot:GARL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GARL_ECOLI ## Database ID URL or Descriptions # BioGrid 4262654 6 # EcoGene EG11919 yjbB # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005315 inorganic phosphate transmembrane transporter activity; IMP:EcoCyc. # GO_function GO:0015321 sodium-dependent phosphate transmembrane transporter activity; IBA:GO_Central. # GO_function YJBB_ECOLI GO 0005436 sodium phosphate symporter activity; IBA GO_Central. # GO_process GO:0030643 cellular phosphate ion homeostasis; IBA:GO_Central. # GO_process GO:0035435 phosphate ion transmembrane transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0042592 homeostatic process # GOslim_process GO:0055085 transmembrane transport # InterPro IPR003841 Na/Pi_transpt # InterPro IPR004633 NaPi_cotrn-rel/YqeW-like # KEGG_Brite ko02000 Transporters # Organism YJBB_ECOLI Escherichia coli (strain K12) # PATRIC 32123569 VBIEscCol129921_4133 # PIR C65209 C65209 # Pfam PF02690 Na_Pi_cotrans; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJBB_ECOLI Uncharacterized protein YjbB # RefSeq NP_418444 NC_000913.3 # RefSeq WP_000956830 NZ_LN832404.1 # SIMILARITY To B.subtilis YqeW. {ECO 0000305}. # SUBCELLULAR LOCATION YJBB_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000305}. # TCDB 2.A.58.2:the phosphate na(+) symporter (pnas) family # TIGRFAMs TIGR00704 NaPi_cotrn_rel # TIGRFAMs TIGR01013 2a58 # eggNOG COG1283 LUCA # eggNOG ENOG4105EAM Bacteria BLAST swissprot:YJBB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJBB_ECOLI BioCyc ECOL316407:JW3980-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3980-MONOMER BioCyc EcoCyc:EG11919-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11919-MONOMER BioCyc MetaCyc:EG11919-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11919-MONOMER COG COG1283 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1283 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1863 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1863 EcoGene EG11919 http://www.ecogene.org/geneInfo.php?eg_id=EG11919 EnsemblBacteria AAC76990 http://www.ensemblgenomes.org/id/AAC76990 EnsemblBacteria AAC76990 http://www.ensemblgenomes.org/id/AAC76990 EnsemblBacteria BAE78022 http://www.ensemblgenomes.org/id/BAE78022 EnsemblBacteria BAE78022 http://www.ensemblgenomes.org/id/BAE78022 EnsemblBacteria BAE78022 http://www.ensemblgenomes.org/id/BAE78022 EnsemblBacteria b4020 http://www.ensemblgenomes.org/id/b4020 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005315 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005315 GO_function GO:0005436 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005436 GO_function GO:0015321 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015321 GO_process GO:0030643 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030643 GO_process GO:0035435 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035435 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 948521 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948521 HOGENOM HOG000126841 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126841&db=HOGENOM6 InParanoid P0AF43 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AF43 InterPro IPR003841 http://www.ebi.ac.uk/interpro/entry/IPR003841 InterPro IPR004633 http://www.ebi.ac.uk/interpro/entry/IPR004633 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3980 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3980 KEGG_Gene eco:b4020 http://www.genome.jp/dbget-bin/www_bget?eco:b4020 KEGG_Orthology KO:K03324 http://www.genome.jp/dbget-bin/www_bget?KO:K03324 OMA QIANANT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QIANANT PSORT swissprot:YJBB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJBB_ECOLI PSORT-B swissprot:YJBB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJBB_ECOLI PSORT2 swissprot:YJBB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJBB_ECOLI Pfam PF02690 http://pfam.xfam.org/family/PF02690 Phobius swissprot:YJBB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJBB_ECOLI PhylomeDB P0AF43 http://phylomedb.org/?seqid=P0AF43 ProteinModelPortal P0AF43 http://www.proteinmodelportal.org/query/uniprot/P0AF43 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418444 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418444 RefSeq WP_000956830 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000956830 SMR P0AF43 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AF43 STRING 511145.b4020 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4020&targetmode=cogs STRING COG1283 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1283&targetmode=cogs TCDB 2.A.58.2 http://www.tcdb.org/search/result.php?tc=2.A.58.2 TIGRFAMs TIGR00704 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00704 TIGRFAMs TIGR01013 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01013 UniProtKB YJBB_ECOLI http://www.uniprot.org/uniprot/YJBB_ECOLI UniProtKB-AC P0AF43 http://www.uniprot.org/uniprot/P0AF43 charge swissprot:YJBB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJBB_ECOLI eggNOG COG1283 http://eggnogapi.embl.de/nog_data/html/tree/COG1283 eggNOG ENOG4105EAM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EAM epestfind swissprot:YJBB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJBB_ECOLI garnier swissprot:YJBB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJBB_ECOLI helixturnhelix swissprot:YJBB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJBB_ECOLI hmoment swissprot:YJBB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJBB_ECOLI iep swissprot:YJBB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJBB_ECOLI inforesidue swissprot:YJBB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJBB_ECOLI octanol swissprot:YJBB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJBB_ECOLI pepcoil swissprot:YJBB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJBB_ECOLI pepdigest swissprot:YJBB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJBB_ECOLI pepinfo swissprot:YJBB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJBB_ECOLI pepnet swissprot:YJBB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJBB_ECOLI pepstats swissprot:YJBB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJBB_ECOLI pepwheel swissprot:YJBB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJBB_ECOLI pepwindow swissprot:YJBB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJBB_ECOLI sigcleave swissprot:YJBB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJBB_ECOLI ## Database ID URL or Descriptions # AltName MENI_ECOLI DHNA-CoA thioesterase {ECO 0000255|HAMAP-Rule MF_01936, ECO 0000303|PubMed 23564174} # BIOPHYSICOCHEMICAL PROPERTIES MENI_ECOLI Kinetic parameters KM=2.5 uM for 1,4-dihydroxy-2-naphthoyl-CoA {ECO 0000269|PubMed 23564174}; KM=8 uM for 1,4-dihydroxy-2-naphthoyl-CoA {ECO 0000269|PubMed 24992697}; KM=1.3 uM for oleoyl-CoA {ECO 0000269|PubMed 24992697}; KM=1.5 uM for myristoyl-CoA {ECO 0000269|PubMed 24992697}; KM=1.559 uM for acetyl-CoA {ECO 0000269|PubMed 23564174}; KM=1.9 uM for palmitoyl-CoA {ECO 0000269|PubMed 24992697}; KM=2.2 uM for lauroyl-CoA {ECO 0000269|PubMed 24992697}; KM=8.0 uM for 1-hydroxy-2-naphthoyl-CoA {ECO 0000269|PubMed 23564174}; KM=9 uM for 4-hydroxybenzoyl-CoA {ECO 0000269|PubMed 24992697}; KM=21 uM for hexanoyl-CoA {ECO 0000269|PubMed 24992697}; KM=25 uM for benzoyl-CoA {ECO 0000269|PubMed 24992697}; KM=26.5 uM for 3,5-dihydroxybenzoyl-CoA {ECO 0000269|PubMed 23564174}; KM=26.9 uM for 3,4-dihydroxybenzoyl-CoA {ECO 0000269|PubMed 23564174}; KM=30 uM for coumaroyl-CoA {ECO 0000269|PubMed 24992697}; KM=54 uM for benzoyl-ACP {ECO 0000269|PubMed 24992697}; KM=69.4 uM for beta-methylcrotonyl-CoA {ECO 0000269|PubMed 24992697}; KM=73 uM for salicylyl-CoA {ECO 0000269|PubMed 23564174}; KM=115 uM for beta-methylmalonyl-CoA {ECO 0000269|PubMed 24992697}; KM=120 uM for propionyl-CoA {ECO 0000269|PubMed 24992697}; KM=200 uM for 2,4-dihydroxybenzoyl-EntB {ECO 0000269|PubMed 24992697}; Note=kcat is 6.2 sec(-1) with 1,4-dihydroxy-2-naphthoyl-CoA (PubMed 23564174). kcat is 1.6 sec(-1) with 1,4-dihydroxy-2- naphthoyl-CoA (PubMed 24992697). kcat is 0.12 sec(-1) with oleoyl-CoA. kcat is 0.62 sec(-1) with myristoyl-CoA. kcat is 0.0044 sec(-1) with acetyl-CoA. kcat is 0.58 sec(-1) with palmitoyl-CoA. kcat is 0.74 sec(-1) with lauroyl-CoA. kcat is 14.8 sec(-1) with 1-hydroxy-2-naphthoyl-CoA. kcat is 5.2 sec(-1) with 4-hydroxybenzoyl-CoA. kcat is 0.3 sec(-1) with hexanoyl- CoA. kcat is 17.7 sec(-1) with benzoyl-CoA. kcat is 12.6 sec(-1) with 3,5-dihydroxybenzoyl-CoA. kcat is 23.2 sec(-1) with 3,4- dihydroxybenzoyl-CoA. kcat is 8.4 sec(-1) with coumaroyl-CoA. kcat is 0.083 sec(-1) with benzoyl-ACP. kcat is 0.5 sec(-1) with beta-methylcrotonyl-CoA. kcat is 93.0 sec(-1) with salicylyl- CoA. kcat is 0.67 sec(-1) with beta-methylmalonyl-CoA. kcat is 0.21 sec(-1) with propionyl-CoA. kcat is 0.0036 sec(-1) with 2,4-dihydroxybenzoyl-EntB. {ECO 0000269|PubMed 23564174, ECO 0000269|PubMed 24992697}; # BRENDA 3.1.2 2026 # BioGrid 4259131 5 # CATALYTIC ACTIVITY MENI_ECOLI 1,4-dihydroxy-2-naphthoyl-CoA + H(2)O = 1,4- dihydroxy-2-naphthoate + CoA. {ECO 0000255|HAMAP-Rule MF_01936, ECO 0000269|PubMed 23564174, ECO 0000269|PubMed 24992697}. # DISRUPTION PHENOTYPE Deletion results in a significant decrease in menaquinone production. {ECO:0000269|PubMed 23564174}. # EcoGene EG13968 menI # FUNCTION MENI_ECOLI Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl- CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA). Also shows significant activity toward a wide range of acyl-CoA thioesters, and minimal activity toward benzoyl-holoEntB. {ECO 0000269|PubMed 15808744, ECO 0000269|PubMed 23564174, ECO 0000269|PubMed 24992697}. # GO_function GO:0016289 CoA hydrolase activity; IDA:EcoCyc. # GO_function GO:0016787 hydrolase activity; IDA:EcoCyc. # GO_function GO:0061522 1,4-dihydroxy-2-naphthoyl-CoA thioesterase activity; IDA:EcoCyc. # GO_process GO:0009234 menaquinone biosynthetic process; IMP:CACAO. # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.10.129.10 -; 1. # HAMAP MF_01936 MenI # IntAct P77781 2 # InterPro IPR003736 PAAI_dom # InterPro IPR006683 Thioestr_dom # InterPro IPR029069 HotDog_dom # InterPro IPR030863 MenI # Organism MENI_ECOLI Escherichia coli (strain K12) # PATHWAY MENI_ECOLI Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate step 7/7. {ECO 0000255|HAMAP-Rule MF_01936, ECO 0000269|PubMed 23564174, ECO 0000269|PubMed 24992697}. # PATHWAY MENI_ECOLI Quinol/quinone metabolism; menaquinone biosynthesis. {ECO 0000255|HAMAP-Rule MF_01936, ECO 0000269|PubMed 23564174, ECO 0000269|PubMed 24992697}. # PATRIC 32118678 VBIEscCol129921_1757 # PDB 1SBK X-ray; 2.00 A; A/B/C/D=1-136 # PDB 1VH5 X-ray; 1.34 A; A/B=2-136 # PDB 1VI8 X-ray; 2.20 A; A/B/C/D/E/F/G/H=2-136 # PDB 4K49 X-ray; 1.89 A; A/B/C/D=1-136 # PDB 4K4A X-ray; 1.89 A; A/B/C/D=1-136 # PDB 4K4B X-ray; 1.90 A; A/B/C/D/E/F/G/H=1-136 # PIR F64926 F64926 # Pfam PF03061 4HBT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 1,4-dihydroxy-2-naphthoyl-CoA hydrolase {ECO:0000255|HAMAP-Rule MF_01936, ECO:0000305} # RefSeq NP_416201 NC_000913.3 # RefSeq WP_000637982 NZ_LN832404.1 # SIMILARITY Belongs to the thioesterase PaaI family. {ECO:0000255|HAMAP-Rule MF_01936}. # SUBUNIT MENI_ECOLI Homotetramer. Dimer of dimers. {ECO 0000255|HAMAP- Rule MF_01936, ECO 0000269|PubMed 25010423}. # SUPFAM SSF54637 SSF54637 # TIGRFAMs TIGR00369 unchar_dom_1 # UniPathway UPA01057 UER01033 # eggNOG COG2050 LUCA # eggNOG ENOG4105KA0 Bacteria BLAST swissprot:MENI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MENI_ECOLI BioCyc ECOL316407:JW1676-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1676-MONOMER BioCyc EcoCyc:G6912-MONOMER http://biocyc.org/getid?id=EcoCyc:G6912-MONOMER BioCyc MetaCyc:G6912-MONOMER http://biocyc.org/getid?id=MetaCyc:G6912-MONOMER DIP DIP-11750N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11750N DOI 10.1002/prot.20541 http://dx.doi.org/10.1002/prot.20541 DOI 10.1016/j.fmrre.2004.12.006 http://dx.doi.org/10.1016/j.fmrre.2004.12.006 DOI 10.1021/bi500333m http://dx.doi.org/10.1021/bi500333m DOI 10.1021/bi500334v http://dx.doi.org/10.1021/bi500334v DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00141-13 http://dx.doi.org/10.1128/JB.00141-13 EC_number EC:3.1.2.28 {ECO:0000255|HAMAP-Rule:MF_01936, ECO:0000269|PubMed:23564174, ECO:0000269|PubMed:24992697} http://www.genome.jp/dbget-bin/www_bget?EC:3.1.2.28 {ECO:0000255|HAMAP-Rule:MF_01936, ECO:0000269|PubMed:23564174, ECO:0000269|PubMed:24992697} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.2.28 {ECO:0000255|HAMAP-Rule:MF_01936, ECO:0000269|PubMed:23564174, ECO:0000269|PubMed:24992697} http://enzyme.expasy.org/EC/3.1.2.28 {ECO:0000255|HAMAP-Rule:MF_01936, ECO:0000269|PubMed:23564174, ECO:0000269|PubMed:24992697} EchoBASE EB3725 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3725 EcoGene EG13968 http://www.ecogene.org/geneInfo.php?eg_id=EG13968 EnsemblBacteria AAC74756 http://www.ensemblgenomes.org/id/AAC74756 EnsemblBacteria AAC74756 http://www.ensemblgenomes.org/id/AAC74756 EnsemblBacteria BAA15452 http://www.ensemblgenomes.org/id/BAA15452 EnsemblBacteria BAA15452 http://www.ensemblgenomes.org/id/BAA15452 EnsemblBacteria BAA15452 http://www.ensemblgenomes.org/id/BAA15452 EnsemblBacteria b1686 http://www.ensemblgenomes.org/id/b1686 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016289 GO_function GO:0016787 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016787 GO_function GO:0061522 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061522 GO_process GO:0009234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.10.129.10 http://www.cathdb.info/version/latest/superfamily/3.10.129.10 GeneID 946190 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946190 HAMAP MF_01936 http://hamap.expasy.org/unirule/MF_01936 HOGENOM HOG000066991 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000066991&db=HOGENOM6 InParanoid P77781 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77781 IntAct P77781 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77781* IntEnz 3.1.2.28 {ECO:0000255|HAMAP-Rule:MF_01936, ECO:0000269|PubMed:23564174, ECO:0000269|PubMed:24992697} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.2.28 {ECO:0000255|HAMAP-Rule:MF_01936, ECO:0000269|PubMed:23564174, ECO:0000269|PubMed:24992697} InterPro IPR003736 http://www.ebi.ac.uk/interpro/entry/IPR003736 InterPro IPR006683 http://www.ebi.ac.uk/interpro/entry/IPR006683 InterPro IPR029069 http://www.ebi.ac.uk/interpro/entry/IPR029069 InterPro IPR030863 http://www.ebi.ac.uk/interpro/entry/IPR030863 KEGG_Gene ecj:JW1676 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1676 KEGG_Gene eco:b1686 http://www.genome.jp/dbget-bin/www_bget?eco:b1686 OMA TQVWQID http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TQVWQID PDB 1SBK http://www.ebi.ac.uk/pdbe-srv/view/entry/1SBK PDB 1VH5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1VH5 PDB 1VI8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1VI8 PDB 4K49 http://www.ebi.ac.uk/pdbe-srv/view/entry/4K49 PDB 4K4A http://www.ebi.ac.uk/pdbe-srv/view/entry/4K4A PDB 4K4B http://www.ebi.ac.uk/pdbe-srv/view/entry/4K4B PDBsum 1SBK http://www.ebi.ac.uk/pdbsum/1SBK PDBsum 1VH5 http://www.ebi.ac.uk/pdbsum/1VH5 PDBsum 1VI8 http://www.ebi.ac.uk/pdbsum/1VI8 PDBsum 4K49 http://www.ebi.ac.uk/pdbsum/4K49 PDBsum 4K4A http://www.ebi.ac.uk/pdbsum/4K4A PDBsum 4K4B http://www.ebi.ac.uk/pdbsum/4K4B PSORT swissprot:MENI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MENI_ECOLI PSORT-B swissprot:MENI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MENI_ECOLI PSORT2 swissprot:MENI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MENI_ECOLI Pfam PF03061 http://pfam.xfam.org/family/PF03061 Phobius swissprot:MENI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MENI_ECOLI PhylomeDB P77781 http://phylomedb.org/?seqid=P77781 ProteinModelPortal P77781 http://www.proteinmodelportal.org/query/uniprot/P77781 PubMed 15808744 http://www.ncbi.nlm.nih.gov/pubmed/15808744 PubMed 16021622 http://www.ncbi.nlm.nih.gov/pubmed/16021622 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 23564174 http://www.ncbi.nlm.nih.gov/pubmed/23564174 PubMed 24992697 http://www.ncbi.nlm.nih.gov/pubmed/24992697 PubMed 25010423 http://www.ncbi.nlm.nih.gov/pubmed/25010423 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416201 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416201 RefSeq WP_000637982 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000637982 SMR P77781 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77781 STRING 511145.b1686 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1686&targetmode=cogs SUPFAM SSF54637 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54637 TIGRFAMs TIGR00369 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00369 UniProtKB MENI_ECOLI http://www.uniprot.org/uniprot/MENI_ECOLI UniProtKB-AC P77781 http://www.uniprot.org/uniprot/P77781 charge swissprot:MENI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MENI_ECOLI eggNOG COG2050 http://eggnogapi.embl.de/nog_data/html/tree/COG2050 eggNOG ENOG4105KA0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105KA0 epestfind swissprot:MENI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MENI_ECOLI garnier swissprot:MENI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MENI_ECOLI helixturnhelix swissprot:MENI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MENI_ECOLI hmoment swissprot:MENI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MENI_ECOLI iep swissprot:MENI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MENI_ECOLI inforesidue swissprot:MENI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MENI_ECOLI octanol swissprot:MENI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MENI_ECOLI pepcoil swissprot:MENI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MENI_ECOLI pepdigest swissprot:MENI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MENI_ECOLI pepinfo swissprot:MENI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MENI_ECOLI pepnet swissprot:MENI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MENI_ECOLI pepstats swissprot:MENI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MENI_ECOLI pepwheel swissprot:MENI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MENI_ECOLI pepwindow swissprot:MENI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MENI_ECOLI sigcleave swissprot:MENI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MENI_ECOLI ## Database ID URL or Descriptions # BioGrid 4263305 240 # CATALYTIC ACTIVITY WAAU_ECOLI UDP-N-acetyl-alpha-D-glucosamine + [lipopolysaccharide] = UDP + N-acetyl-alpha-D-glucosaminyl- [lipopolysaccharide]. # CAZy GT9 Glycosyltransferase Family 9 # EcoGene EG11423 waaU # FUNCTION WAAU_ECOLI Adds the terminal N-acetyl-D-glucosamine group on the glucose(II) group of LPS. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_component GO:0016020 membrane; IEA:UniProtKB-SubCell. # GO_function GO:0008713 ADP-heptose-lipopolysaccharide heptosyltransferase activity; IBA:GO_Central. # GO_function GO:0008917 lipopolysaccharide N-acetylglucosaminyltransferase activity; IMP:EcoCyc. # GO_function GO:0016757 transferase activity, transferring glycosyl groups; IMP:EcoCyc. # GO_process GO:0009244 lipopolysaccharide core region biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # IntAct P27242 7 # InterPro IPR002201 Glyco_trans_9 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01003 Glycosyltransferases # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # KEGG_Pathway ko00540 Lipopolysaccharide biosynthesis # Organism WAAU_ECOLI Escherichia coli (strain K12) # PATHWAY WAAU_ECOLI Bacterial outer membrane biogenesis; LPS core biosynthesis. # PATRIC 32122733 VBIEscCol129921_3743 # PIR A65163 A65163 # Pfam PF01075 Glyco_transf_9 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName WAAU_ECOLI Lipopolysaccharide 1,2-N-acetylglucosaminetransferase # RefSeq NP_418080 NC_000913.3 # RefSeq WP_001236433 NZ_LN832404.1 # SUBCELLULAR LOCATION WAAU_ECOLI Membrane; Peripheral membrane protein. # eggNOG COG0859 LUCA # eggNOG ENOG4108XNZ Bacteria BLAST swissprot:WAAU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:WAAU_ECOLI BioCyc ECOL316407:JW3598-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3598-MONOMER BioCyc EcoCyc:EG11423-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11423-MONOMER BioCyc MetaCyc:EG11423-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11423-MONOMER COG COG0859 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0859 DIP DIP-10672N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10672N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.4.1.56 http://www.genome.jp/dbget-bin/www_bget?EC:2.4.1.56 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M95398 http://www.ebi.ac.uk/ena/data/view/M95398 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.4.1.56 http://enzyme.expasy.org/EC/2.4.1.56 EchoBASE EB1393 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1393 EcoGene EG11423 http://www.ecogene.org/geneInfo.php?eg_id=EG11423 EnsemblBacteria AAC76647 http://www.ensemblgenomes.org/id/AAC76647 EnsemblBacteria AAC76647 http://www.ensemblgenomes.org/id/AAC76647 EnsemblBacteria BAE77669 http://www.ensemblgenomes.org/id/BAE77669 EnsemblBacteria BAE77669 http://www.ensemblgenomes.org/id/BAE77669 EnsemblBacteria BAE77669 http://www.ensemblgenomes.org/id/BAE77669 EnsemblBacteria b3623 http://www.ensemblgenomes.org/id/b3623 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0008713 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008713 GO_function GO:0008917 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008917 GO_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GO_process GO:0009244 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009244 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 948147 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948147 HOGENOM HOG000054846 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000054846&db=HOGENOM6 InParanoid P27242 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P27242 IntAct P27242 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P27242* IntEnz 2.4.1.56 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.1.56 InterPro IPR002201 http://www.ebi.ac.uk/interpro/entry/IPR002201 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01003 http://www.genome.jp/dbget-bin/www_bget?ko01003 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Gene ecj:JW3598 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3598 KEGG_Gene eco:b3623 http://www.genome.jp/dbget-bin/www_bget?eco:b3623 KEGG_Orthology KO:K03277 http://www.genome.jp/dbget-bin/www_bget?KO:K03277 KEGG_Pathway ko00540 http://www.genome.jp/kegg-bin/show_pathway?ko00540 MINT MINT-1231283 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1231283 OMA HIASGFN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HIASGFN PSORT swissprot:WAAU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:WAAU_ECOLI PSORT-B swissprot:WAAU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:WAAU_ECOLI PSORT2 swissprot:WAAU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:WAAU_ECOLI Pfam PF01075 http://pfam.xfam.org/family/PF01075 Phobius swissprot:WAAU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:WAAU_ECOLI PhylomeDB P27242 http://phylomedb.org/?seqid=P27242 ProteinModelPortal P27242 http://www.proteinmodelportal.org/query/uniprot/P27242 PubMed 1624462 http://www.ncbi.nlm.nih.gov/pubmed/1624462 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418080 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418080 RefSeq WP_001236433 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001236433 STRING 511145.b3623 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3623&targetmode=cogs STRING COG0859 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0859&targetmode=cogs UniProtKB WAAU_ECOLI http://www.uniprot.org/uniprot/WAAU_ECOLI UniProtKB-AC P27242 http://www.uniprot.org/uniprot/P27242 charge swissprot:WAAU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:WAAU_ECOLI eggNOG COG0859 http://eggnogapi.embl.de/nog_data/html/tree/COG0859 eggNOG ENOG4108XNZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108XNZ epestfind swissprot:WAAU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:WAAU_ECOLI garnier swissprot:WAAU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:WAAU_ECOLI helixturnhelix swissprot:WAAU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:WAAU_ECOLI hmoment swissprot:WAAU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:WAAU_ECOLI iep swissprot:WAAU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:WAAU_ECOLI inforesidue swissprot:WAAU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:WAAU_ECOLI octanol swissprot:WAAU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:WAAU_ECOLI pepcoil swissprot:WAAU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:WAAU_ECOLI pepdigest swissprot:WAAU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:WAAU_ECOLI pepinfo swissprot:WAAU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:WAAU_ECOLI pepnet swissprot:WAAU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:WAAU_ECOLI pepstats swissprot:WAAU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:WAAU_ECOLI pepwheel swissprot:WAAU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:WAAU_ECOLI pepwindow swissprot:WAAU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:WAAU_ECOLI sigcleave swissprot:WAAU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:WAAU_ECOLI ## Database ID URL or Descriptions # BioGrid 4260979 237 # EcoGene EG12929 hslR # FUNCTION HSLR_ECOLI Involved in the recycling of free 50S ribosomal subunits that still carry a nascent chain. Binds RNA more specifically than DNA. Binds with very high affinity to the free 50S ribosomal subunit. Does not bind it when it is part of the 70S ribosome. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0003727 single-stranded RNA binding; IDA:EcoCyc. # GO_function GO:0009982 pseudouridine synthase activity; IBA:GO_Central. # GO_function GO:0043023 ribosomal large subunit binding; IDA:EcoCyc. # GO_process GO:0000455 enzyme-directed rRNA pseudouridine synthesis; IBA:GO_Central. # GO_process GO:0009408 response to heat; IEP:EcoliWiki. # GO_process GO:0034605 cellular response to heat; IEP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0006950 response to stress # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.10.290.10 -; 1. # INDUCTION HSLR_ECOLI By heat shock. # INTERACTION HSLR_ECOLI P06993 malT; NbExp=2; IntAct=EBI-562824, EBI-542934; P0A7V0 rpsB; NbExp=2; IntAct=EBI-562824, EBI-543439; Q79E92 ykgN; NbExp=2; IntAct=EBI-562824, EBI-9131095; # IntAct P0ACG8 37 # InterPro IPR002942 S4_RNA-bd # InterPro IPR025708 HSP15 # KEGG_Brite ko03110 Chaperones and folding catalysts # Organism HSLR_ECOLI Escherichia coli (strain K12) # PATRIC 32122234 VBIEscCol129921_3494 # PDB 1DM9 X-ray; 2.00 A; A/B=1-133 # PDB 3BBU EM; 10.00 A; A=5-108 # PIR C65135 C65135 # PIRSF PIRSF016821 HSP15 # PROSITE PS50889 S4 # Pfam PF01479 S4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HSLR_ECOLI Heat shock protein 15 # RefSeq NP_417859 NC_000913.3 # RefSeq WP_000660483 NZ_LN832404.1 # SIMILARITY Belongs to the HSP15 family. {ECO 0000305}. # SIMILARITY Contains 1 S4 RNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00182}. # SMART SM00363 S4 # SUBUNIT HSLR_ECOLI Monomer. # eggNOG COG1188 LUCA # eggNOG ENOG4105VEJ Bacteria BLAST swissprot:HSLR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HSLR_ECOLI BioCyc ECOL316407:JW3363-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3363-MONOMER BioCyc EcoCyc:G7743-MONOMER http://biocyc.org/getid?id=EcoCyc:G7743-MONOMER COG COG1188 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1188 DIP DIP-48014N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48014N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.274.1.249 http://dx.doi.org/10.1074/jbc.274.1.249 DOI 10.1093/emboj/19.4.741 http://dx.doi.org/10.1093/emboj/19.4.741 DOI 10.1093/emboj/19.4.749 http://dx.doi.org/10.1093/emboj/19.4.749 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2765 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2765 EcoGene EG12929 http://www.ecogene.org/geneInfo.php?eg_id=EG12929 EnsemblBacteria AAC76425 http://www.ensemblgenomes.org/id/AAC76425 EnsemblBacteria AAC76425 http://www.ensemblgenomes.org/id/AAC76425 EnsemblBacteria BAE77891 http://www.ensemblgenomes.org/id/BAE77891 EnsemblBacteria BAE77891 http://www.ensemblgenomes.org/id/BAE77891 EnsemblBacteria BAE77891 http://www.ensemblgenomes.org/id/BAE77891 EnsemblBacteria b3400 http://www.ensemblgenomes.org/id/b3400 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003727 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003727 GO_function GO:0009982 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009982 GO_function GO:0043023 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043023 GO_process GO:0000455 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000455 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GO_process GO:0034605 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034605 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.10.290.10 http://www.cathdb.info/version/latest/superfamily/3.10.290.10 GeneID 947912 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947912 HOGENOM HOG000216822 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000216822&db=HOGENOM6 InParanoid P0ACG8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACG8 IntAct P0ACG8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACG8* InterPro IPR002942 http://www.ebi.ac.uk/interpro/entry/IPR002942 InterPro IPR025708 http://www.ebi.ac.uk/interpro/entry/IPR025708 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW3363 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3363 KEGG_Gene eco:b3400 http://www.genome.jp/dbget-bin/www_bget?eco:b3400 KEGG_Orthology KO:K04762 http://www.genome.jp/dbget-bin/www_bget?KO:K04762 OMA RFYKTRT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RFYKTRT PDB 1DM9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1DM9 PDB 3BBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3BBU PDBsum 1DM9 http://www.ebi.ac.uk/pdbsum/1DM9 PDBsum 3BBU http://www.ebi.ac.uk/pdbsum/3BBU PROSITE PS50889 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50889 PSORT swissprot:HSLR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HSLR_ECOLI PSORT-B swissprot:HSLR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HSLR_ECOLI PSORT2 swissprot:HSLR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HSLR_ECOLI Pfam PF01479 http://pfam.xfam.org/family/PF01479 Phobius swissprot:HSLR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HSLR_ECOLI PhylomeDB P0ACG8 http://phylomedb.org/?seqid=P0ACG8 ProteinModelPortal P0ACG8 http://www.proteinmodelportal.org/query/uniprot/P0ACG8 PubMed 10675343 http://www.ncbi.nlm.nih.gov/pubmed/10675343 PubMed 10675344 http://www.ncbi.nlm.nih.gov/pubmed/10675344 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9867837 http://www.ncbi.nlm.nih.gov/pubmed/9867837 RefSeq NP_417859 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417859 RefSeq WP_000660483 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000660483 SMART SM00363 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00363 SMR P0ACG8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACG8 STRING 511145.b3400 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3400&targetmode=cogs STRING COG1188 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1188&targetmode=cogs UniProtKB HSLR_ECOLI http://www.uniprot.org/uniprot/HSLR_ECOLI UniProtKB-AC P0ACG8 http://www.uniprot.org/uniprot/P0ACG8 charge swissprot:HSLR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HSLR_ECOLI eggNOG COG1188 http://eggnogapi.embl.de/nog_data/html/tree/COG1188 eggNOG ENOG4105VEJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VEJ epestfind swissprot:HSLR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HSLR_ECOLI garnier swissprot:HSLR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HSLR_ECOLI helixturnhelix swissprot:HSLR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HSLR_ECOLI hmoment swissprot:HSLR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HSLR_ECOLI iep swissprot:HSLR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HSLR_ECOLI inforesidue swissprot:HSLR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HSLR_ECOLI octanol swissprot:HSLR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HSLR_ECOLI pepcoil swissprot:HSLR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HSLR_ECOLI pepdigest swissprot:HSLR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HSLR_ECOLI pepinfo swissprot:HSLR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HSLR_ECOLI pepnet swissprot:HSLR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HSLR_ECOLI pepstats swissprot:HSLR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HSLR_ECOLI pepwheel swissprot:HSLR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HSLR_ECOLI pepwindow swissprot:HSLR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HSLR_ECOLI sigcleave swissprot:HSLR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HSLR_ECOLI ## Database ID URL or Descriptions # BioGrid 4259635 31 # EcoGene EG10870 rplI # FUNCTION RL9_ECOLI One of the primary rRNA binding proteins, it binds very close to the 3' end of the 23S rRNA. {ECO 0000269|PubMed 3298242}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0022625 cytosolic large ribosomal subunit; IDA:EcoCyc. # GO_function GO:0003735 structural constituent of ribosome; IEA:InterPro. # GO_function GO:0070180 large ribosomal subunit rRNA binding; IDA:EcoCyc. # GO_process GO:0006412 translation; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_function GO:0019843 rRNA binding # GOslim_process GO:0006412 translation # Gene3D 3.10.430.100 -; 1. # Gene3D 3.40.5.10 -; 1. # HAMAP MF_00503 Ribosomal_L9 # IntAct P0A7R1 59 # InterPro IPR000244 Ribosomal_L9 # InterPro IPR009027 Ribosomal_L9/RNase_H1_N # InterPro IPR020069 Ribosomal_L9_C # InterPro IPR020070 Ribosomal_L9_N # InterPro IPR020594 Ribosomal_L9_bac/chp # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=15769.7; Method=MALDI; Range=1-149; Evidence={ECO:0000269|PubMed 10094780}; # Organism RL9_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21368 PTHR21368 # PATRIC 32123981 VBIEscCol129921_4335 # PDB 2J28 EM; 8.00 A; H=1-149 # PDB 2RDO EM; 9.10 A; H=1-149 # PDB 3BBX EM; 10.00 A; H=1-149 # PDB 3J5L EM; 6.60 A; H=1-56 # PDB 3J7Z EM; 3.90 A; H=1-149 # PDB 3J8G EM; 5.00 A; H=1-149 # PDB 3J9Y EM; 3.90 A; H=1-149 # PDB 3J9Z EM; 3.60 A; L9=1-149 # PDB 3JA1 EM; 3.60 A; LI=1-149 # PDB 3JBU EM; 3.64 A; h=1-149 # PDB 3JBV EM; 3.32 A; h=1-149 # PDB 3JCD EM; 3.70 A; H=1-149 # PDB 3JCE EM; 3.20 A; H=1-149 # PDB 3JCJ EM; 3.70 A; G=1-149 # PDB 3JCN EM; 4.60 A; H=1-149 # PDB 487D EM; 7.50 A; K=24-123 # PDB 4CSU EM; 5.50 A; H=1-149 # PDB 4U1U X-ray; 2.95 A; BH/DH=1-149 # PDB 4U1V X-ray; 3.00 A; BH/DH=1-149 # PDB 4U20 X-ray; 2.90 A; BH/DH=1-149 # PDB 4U24 X-ray; 2.90 A; BH/DH=1-149 # PDB 4U25 X-ray; 2.90 A; BH/DH=1-149 # PDB 4U26 X-ray; 2.80 A; BH/DH=1-149 # PDB 4U27 X-ray; 2.80 A; BH/DH=1-149 # PDB 4UY8 EM; 3.80 A; H=1-50 # PDB 4V47 EM; 12.30 A; AF=1-149 # PDB 4V48 EM; 11.50 A; AF=1-149 # PDB 4V4H X-ray; 3.46 A; BH/DH=1-149 # PDB 4V4Q X-ray; 3.46 A; BH/DH=1-149 # PDB 4V4V EM; 15.00 A; BF=1-149 # PDB 4V4W EM; 15.00 A; BF=1-149 # PDB 4V50 X-ray; 3.22 A; BH/DH=1-149 # PDB 4V52 X-ray; 3.21 A; BH/DH=1-149 # PDB 4V53 X-ray; 3.54 A; BH/DH=1-149 # PDB 4V54 X-ray; 3.30 A; BH/DH=1-149 # PDB 4V55 X-ray; 4.00 A; BH/DH=1-149 # PDB 4V56 X-ray; 3.93 A; BH/DH=1-149 # PDB 4V57 X-ray; 3.50 A; BH/DH=1-149 # PDB 4V5B X-ray; 3.74 A; AH/CH=1-149 # PDB 4V5H EM; 5.80 A; BH=1-149 # PDB 4V5Y X-ray; 4.45 A; BH/DH=1-149 # PDB 4V64 X-ray; 3.50 A; BH/DH=1-149 # PDB 4V65 EM; 9.00 A; B4=1-149 # PDB 4V66 EM; 9.00 A; B4=1-149 # PDB 4V69 EM; 6.70 A; BH=1-149 # PDB 4V6C X-ray; 3.19 A; BH/DH=1-149 # PDB 4V6D X-ray; 3.81 A; BH/DH=1-149 # PDB 4V6E X-ray; 3.71 A; BH/DH=1-149 # PDB 4V6K EM; 8.25 A; AI=1-149 # PDB 4V6L EM; 13.20 A; BI=1-149 # PDB 4V6M EM; 7.10 A; BH=1-149 # PDB 4V6N EM; 12.10 A; AI=1-149 # PDB 4V6O EM; 14.70 A; BI=1-149 # PDB 4V6P EM; 13.50 A; BI=1-149 # PDB 4V6Q EM; 11.50 A; BI=1-149 # PDB 4V6R EM; 11.50 A; BI=1-149 # PDB 4V6S EM; 13.10 A; AI=1-149 # PDB 4V6T EM; 8.30 A; BH=1-149 # PDB 4V6V EM; 9.80 A; BL=1-149 # PDB 4V6Y EM; 12.00 A; BH=1-149 # PDB 4V6Z EM; 12.00 A; BH=1-149 # PDB 4V70 EM; 17.00 A; BH=1-149 # PDB 4V71 EM; 20.00 A; BH=1-149 # PDB 4V72 EM; 13.00 A; BH=1-149 # PDB 4V73 EM; 15.00 A; BH=1-149 # PDB 4V74 EM; 17.00 A; BH=1-149 # PDB 4V75 EM; 12.00 A; BH=1-149 # PDB 4V76 EM; 17.00 A; BH=1-149 # PDB 4V77 EM; 17.00 A; BH=1-149 # PDB 4V78 EM; 20.00 A; BH=1-149 # PDB 4V79 EM; 15.00 A; BH=1-149 # PDB 4V7A EM; 9.00 A; BH=1-149 # PDB 4V7B EM; 6.80 A; BH=1-50 # PDB 4V7C EM; 7.60 A; BI=1-149 # PDB 4V7D EM; 7.60 A; AI=1-149 # PDB 4V7I EM; 9.60 A; AH=1-149 # PDB 4V7S X-ray; 3.25 A; BH/DH=1-149 # PDB 4V7T X-ray; 3.19 A; BH/DH=1-149 # PDB 4V7U X-ray; 3.10 A; BH/DH=1-149 # PDB 4V7V X-ray; 3.29 A; BH/DH=1-149 # PDB 4V9C X-ray; 3.30 A; BH/DH=1-149 # PDB 4V9D X-ray; 3.00 A; CH/DH=1-149 # PDB 4V9O X-ray; 2.90 A; AH/CH/EH/GH=1-50 # PDB 4V9P X-ray; 2.90 A; AH/CH/EH/GH=1-50 # PDB 4WF1 X-ray; 3.09 A; BH/DH=1-149 # PDB 4WOI X-ray; 3.00 A; BH/CH=1-149 # PDB 4WWW X-ray; 3.10 A; RH/YH=1-149 # PDB 4YBB X-ray; 2.10 A; CH/DH=1-149 # PDB 5ADY EM; 4.50 A; H=1-149 # PDB 5AFI EM; 2.90 A; H=1-149 # PDB 5AKA EM; 5.70 A; H=1-149 # PDB 5GAD EM; 3.70 A; H=1-149 # PDB 5GAE EM; 3.33 A; H=1-149 # PDB 5GAF EM; 4.30 A; H=1-149 # PDB 5GAG EM; 3.80 A; H=1-149 # PDB 5GAH EM; 3.80 A; H=1-149 # PDB 5IQR EM; 3.00 A; G=1-149 # PDB 5IT8 X-ray; 3.12 A; CH/DH=1-149 # PDB 5J5B X-ray; 2.80 A; CH/DH=1-149 # PDB 5J7L X-ray; 3.00 A; CH/DH=1-149 # PDB 5J88 X-ray; 3.32 A; CH/DH=1-149 # PDB 5J8A X-ray; 3.10 A; CH/DH=1-149 # PDB 5J91 X-ray; 2.96 A; CH/DH=1-149 # PDB 5JC9 X-ray; 3.03 A; CH/DH=1-149 # PDB 5JTE EM; 3.60 A; BH=1-149 # PDB 5JU8 EM; 3.60 A; BH=1-149 # PDB 5KCR EM; 3.60 A; 1I=1-149 # PDB 5KCS EM; 3.90 A; 1I=1-149 # PDB 5KPS EM; 3.90 A; G=1-149 # PDB 5KPV EM; 4.10 A; F=1-149 # PDB 5KPW EM; 3.90 A; F=1-149 # PDB 5KPX EM; 3.90 A; F=1-149 # PDB 5L3P EM; 3.70 A; I=1-149 # PIR F65231 R5EC9 # PROSITE PS00651 RIBOSOMAL_L9 # Pfam PF01281 Ribosomal_L9_N # Pfam PF03948 Ribosomal_L9_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RL9_ECOLI 50S ribosomal protein L9 # RefSeq NP_418624 NC_000913.3 # RefSeq WP_001196062 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein L9P family. {ECO 0000305}. # SUBUNIT RL9_ECOLI Part of the 50S ribosomal subunit. # SUPFAM SSF55653 SSF55653 # SUPFAM SSF55658 SSF55658 # TIGRFAMs TIGR00158 L9 # eggNOG COG0359 LUCA # eggNOG ENOG4105K9Q Bacteria BLAST swissprot:RL9_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RL9_ECOLI BioCyc ECOL316407:JW4161-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4161-MONOMER BioCyc EcoCyc:EG10870-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10870-MONOMER BioCyc MetaCyc:EG10870-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10870-MONOMER COG COG0359 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0359 DIP DIP-35748N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35748N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1006/jmbi.1998.1726 http://dx.doi.org/10.1006/jmbi.1998.1726 DOI 10.1006/jmbi.2000.3635 http://dx.doi.org/10.1006/jmbi.2000.3635 DOI 10.1007/BF00330199 http://dx.doi.org/10.1007/BF00330199 DOI 10.1016/S0092-8674(03)00427-6 http://dx.doi.org/10.1016/S0092-8674(03)00427-6 DOI 10.1016/j.celrep.2014.09.011 http://dx.doi.org/10.1016/j.celrep.2014.09.011 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nchembio.495 http://dx.doi.org/10.1038/nchembio.495 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pbio.1001866 http://dx.doi.org/10.1371/journal.pbio.1001866 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X04022 http://www.ebi.ac.uk/ena/data/view/X04022 EchoBASE EB0863 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0863 EcoGene EG10870 http://www.ecogene.org/geneInfo.php?eg_id=EG10870 EnsemblBacteria AAC77160 http://www.ensemblgenomes.org/id/AAC77160 EnsemblBacteria AAC77160 http://www.ensemblgenomes.org/id/AAC77160 EnsemblBacteria BAE78204 http://www.ensemblgenomes.org/id/BAE78204 EnsemblBacteria BAE78204 http://www.ensemblgenomes.org/id/BAE78204 EnsemblBacteria BAE78204 http://www.ensemblgenomes.org/id/BAE78204 EnsemblBacteria b4203 http://www.ensemblgenomes.org/id/b4203 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0022625 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022625 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_function GO:0070180 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070180 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 Gene3D 3.10.430.100 http://www.cathdb.info/version/latest/superfamily/3.10.430.100 Gene3D 3.40.5.10 http://www.cathdb.info/version/latest/superfamily/3.40.5.10 GeneID 948720 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948720 HAMAP MF_00503 http://hamap.expasy.org/unirule/MF_00503 HOGENOM HOG000040337 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000040337&db=HOGENOM6 InParanoid P0A7R1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7R1 IntAct P0A7R1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7R1* InterPro IPR000244 http://www.ebi.ac.uk/interpro/entry/IPR000244 InterPro IPR009027 http://www.ebi.ac.uk/interpro/entry/IPR009027 InterPro IPR020069 http://www.ebi.ac.uk/interpro/entry/IPR020069 InterPro IPR020070 http://www.ebi.ac.uk/interpro/entry/IPR020070 InterPro IPR020594 http://www.ebi.ac.uk/interpro/entry/IPR020594 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW4161 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4161 KEGG_Gene eco:b4203 http://www.genome.jp/dbget-bin/www_bget?eco:b4203 KEGG_Orthology KO:K02939 http://www.genome.jp/dbget-bin/www_bget?KO:K02939 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 MINT MINT-1228834 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1228834 OMA AIRWTKG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AIRWTKG PANTHER PTHR21368 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21368 PDB 2J28 http://www.ebi.ac.uk/pdbe-srv/view/entry/2J28 PDB 2RDO http://www.ebi.ac.uk/pdbe-srv/view/entry/2RDO PDB 3BBX http://www.ebi.ac.uk/pdbe-srv/view/entry/3BBX PDB 3J5L http://www.ebi.ac.uk/pdbe-srv/view/entry/3J5L PDB 3J7Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J7Z PDB 3J8G http://www.ebi.ac.uk/pdbe-srv/view/entry/3J8G PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 487D http://www.ebi.ac.uk/pdbe-srv/view/entry/487D PDB 4CSU http://www.ebi.ac.uk/pdbe-srv/view/entry/4CSU PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4UY8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4UY8 PDB 4V47 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V47 PDB 4V48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V48 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5ADY http://www.ebi.ac.uk/pdbe-srv/view/entry/5ADY PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5AKA http://www.ebi.ac.uk/pdbe-srv/view/entry/5AKA PDB 5GAD http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAD PDB 5GAE http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAE PDB 5GAF http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAF PDB 5GAG http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAG PDB 5GAH http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAH PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 2J28 http://www.ebi.ac.uk/pdbsum/2J28 PDBsum 2RDO http://www.ebi.ac.uk/pdbsum/2RDO PDBsum 3BBX http://www.ebi.ac.uk/pdbsum/3BBX PDBsum 3J5L http://www.ebi.ac.uk/pdbsum/3J5L PDBsum 3J7Z http://www.ebi.ac.uk/pdbsum/3J7Z PDBsum 3J8G http://www.ebi.ac.uk/pdbsum/3J8G PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 487D http://www.ebi.ac.uk/pdbsum/487D PDBsum 4CSU http://www.ebi.ac.uk/pdbsum/4CSU PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4UY8 http://www.ebi.ac.uk/pdbsum/4UY8 PDBsum 4V47 http://www.ebi.ac.uk/pdbsum/4V47 PDBsum 4V48 http://www.ebi.ac.uk/pdbsum/4V48 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5ADY http://www.ebi.ac.uk/pdbsum/5ADY PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5AKA http://www.ebi.ac.uk/pdbsum/5AKA PDBsum 5GAD http://www.ebi.ac.uk/pdbsum/5GAD PDBsum 5GAE http://www.ebi.ac.uk/pdbsum/5GAE PDBsum 5GAF http://www.ebi.ac.uk/pdbsum/5GAF PDBsum 5GAG http://www.ebi.ac.uk/pdbsum/5GAG PDBsum 5GAH http://www.ebi.ac.uk/pdbsum/5GAH PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PROSITE PS00651 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00651 PSORT swissprot:RL9_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RL9_ECOLI PSORT-B swissprot:RL9_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RL9_ECOLI PSORT2 swissprot:RL9_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RL9_ECOLI Pfam PF01281 http://pfam.xfam.org/family/PF01281 Pfam PF03948 http://pfam.xfam.org/family/PF03948 Phobius swissprot:RL9_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RL9_ECOLI PhylomeDB P0A7R1 http://phylomedb.org/?seqid=P0A7R1 ProteinModelPortal P0A7R1 http://www.proteinmodelportal.org/query/uniprot/P0A7R1 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 10756104 http://www.ncbi.nlm.nih.gov/pubmed/10756104 PubMed 12809609 http://www.ncbi.nlm.nih.gov/pubmed/12809609 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 21151122 http://www.ncbi.nlm.nih.gov/pubmed/21151122 PubMed 24844575 http://www.ncbi.nlm.nih.gov/pubmed/24844575 PubMed 25310980 http://www.ncbi.nlm.nih.gov/pubmed/25310980 PubMed 3298242 http://www.ncbi.nlm.nih.gov/pubmed/3298242 PubMed 3528756 http://www.ncbi.nlm.nih.gov/pubmed/3528756 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 RefSeq NP_418624 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418624 RefSeq WP_001196062 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001196062 SMR P0A7R1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7R1 STRING 511145.b4203 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4203&targetmode=cogs STRING COG0359 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0359&targetmode=cogs SUPFAM SSF55653 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55653 SUPFAM SSF55658 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55658 SWISS-2DPAGE P0A7R1 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A7R1 TIGRFAMs TIGR00158 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00158 UniProtKB RL9_ECOLI http://www.uniprot.org/uniprot/RL9_ECOLI UniProtKB-AC P0A7R1 http://www.uniprot.org/uniprot/P0A7R1 charge swissprot:RL9_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RL9_ECOLI eggNOG COG0359 http://eggnogapi.embl.de/nog_data/html/tree/COG0359 eggNOG ENOG4105K9Q http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K9Q epestfind swissprot:RL9_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RL9_ECOLI garnier swissprot:RL9_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RL9_ECOLI helixturnhelix swissprot:RL9_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RL9_ECOLI hmoment swissprot:RL9_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RL9_ECOLI iep swissprot:RL9_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RL9_ECOLI inforesidue swissprot:RL9_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RL9_ECOLI octanol swissprot:RL9_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RL9_ECOLI pepcoil swissprot:RL9_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RL9_ECOLI pepdigest swissprot:RL9_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RL9_ECOLI pepinfo swissprot:RL9_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RL9_ECOLI pepnet swissprot:RL9_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RL9_ECOLI pepstats swissprot:RL9_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RL9_ECOLI pepwheel swissprot:RL9_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RL9_ECOLI pepwindow swissprot:RL9_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RL9_ECOLI sigcleave swissprot:RL9_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RL9_ECOLI ## Database ID URL or Descriptions # AltName RAPA_ECOLI ATP-dependent helicase HepA # BioGrid 4262039 359 # DEVELOPMENTAL STAGE During growth phase, peaking during at the early log phase. {ECO:0000269|PubMed 11567013}. # EcoGene EG11083 rapA # FUNCTION RAPA_ECOLI Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity). {ECO 0000250, ECO 0000269|PubMed 11751638}. # GO_function GO:0003676 nucleic acid binding; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0004386 helicase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0016887 ATPase activity; IDA:EcoCyc. # GO_function GO:0070063 RNA polymerase binding; IPI:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004386 helicase activity # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0019899 enzyme binding # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.50.300 -; 2. # HAMAP MF_01821 Helicase_RapA # INTERACTION RAPA_ECOLI P0A8V2 rpoB; NbExp=3; IntAct=EBI-551542, EBI-544996; # IntAct P60240 20 # InterPro IPR000330 SNF2_N # InterPro IPR001650 Helicase_C # InterPro IPR014001 Helicase_ATP-bd # InterPro IPR022737 RapA_C # InterPro IPR023949 Helicase_RapA # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03021 Transcription machinery # Organism RAPA_ECOLI Escherichia coli (strain K12) # PATRIC 32115217 VBIEscCol129921_0060 # PDB 3DMQ X-ray; 3.20 A; A/B=1-968 # PDB 4S20 X-ray; 4.70 A; K/L=1-968 # PIR C64727 C64727 # PROSITE PS51192 HELICASE_ATP_BIND_1 # PROSITE PS51194 HELICASE_CTER # Pfam PF00176 SNF2_N # Pfam PF00271 Helicase_C # Pfam PF12137 RapA_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RAPA_ECOLI RNA polymerase-associated protein RapA # RefSeq NP_414601 NC_000913.3 # RefSeq WP_001117011 NZ_CP011343.2 # SIMILARITY Belongs to the SNF2/RAD54 helicase family. RapA subfamily. {ECO 0000305}. # SIMILARITY Contains 1 helicase ATP-binding domain. {ECO 0000305}. # SIMILARITY Contains 1 helicase C-terminal domain. {ECO 0000305}. # SMART SM00487 DEXDc # SMART SM00490 HELICc # SUBUNIT Interacts with the RNAP. Has a higher affinity for the core RNAP than for the holoenzyme. Its ATPase activity is stimulated by binding to RNAP (By similarity). {ECO 0000250}. # SUPFAM SSF52540 SSF52540; 3 # eggNOG COG0553 LUCA # eggNOG ENOG4105BZK Bacteria BLAST swissprot:RAPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RAPA_ECOLI BioCyc ECOL316407:JW0058-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0058-MONOMER BioCyc EcoCyc:EG11083-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11083-MONOMER COG COG0553 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0553 DIP DIP-35881N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35881N DOI 10.1007/BF00273583 http://dx.doi.org/10.1007/BF00273583 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.273.12.7018 http://dx.doi.org/10.1074/jbc.273.12.7018 DOI 10.1074/jbc.273.24.15157 http://dx.doi.org/10.1074/jbc.273.24.15157 DOI 10.1074/jbc.M000056200 http://dx.doi.org/10.1074/jbc.M000056200 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1093/nar/21.3.751 http://dx.doi.org/10.1093/nar/21.3.751 DOI 10.1101/gad.936701 http://dx.doi.org/10.1101/gad.936701 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.183.20.6126-6134.2001 http://dx.doi.org/10.1128/JB.183.20.6126-6134.2001 EC_number EC:3.6.4.- http://www.genome.jp/dbget-bin/www_bget?EC:3.6.4.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X54847 http://www.ebi.ac.uk/ena/data/view/X54847 ENZYME 3.6.4.- http://enzyme.expasy.org/EC/3.6.4.- EchoBASE EB1075 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1075 EcoGene EG11083 http://www.ecogene.org/geneInfo.php?eg_id=EG11083 EnsemblBacteria AAC73170 http://www.ensemblgenomes.org/id/AAC73170 EnsemblBacteria AAC73170 http://www.ensemblgenomes.org/id/AAC73170 EnsemblBacteria BAB96627 http://www.ensemblgenomes.org/id/BAB96627 EnsemblBacteria BAB96627 http://www.ensemblgenomes.org/id/BAB96627 EnsemblBacteria BAB96627 http://www.ensemblgenomes.org/id/BAB96627 EnsemblBacteria b0059 http://www.ensemblgenomes.org/id/b0059 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003676 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003676 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004386 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_function GO:0070063 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070063 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004386 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0019899 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019899 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948523 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948523 HAMAP MF_01821 http://hamap.expasy.org/unirule/MF_01821 HOGENOM HOG000218482 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218482&db=HOGENOM6 InParanoid P60240 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P60240 IntAct P60240 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P60240* IntEnz 3.6.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.4 InterPro IPR000330 http://www.ebi.ac.uk/interpro/entry/IPR000330 InterPro IPR001650 http://www.ebi.ac.uk/interpro/entry/IPR001650 InterPro IPR014001 http://www.ebi.ac.uk/interpro/entry/IPR014001 InterPro IPR022737 http://www.ebi.ac.uk/interpro/entry/IPR022737 InterPro IPR023949 http://www.ebi.ac.uk/interpro/entry/IPR023949 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03021 http://www.genome.jp/dbget-bin/www_bget?ko03021 KEGG_Gene ecj:JW0058 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0058 KEGG_Gene eco:b0059 http://www.genome.jp/dbget-bin/www_bget?eco:b0059 KEGG_Orthology KO:K03580 http://www.genome.jp/dbget-bin/www_bget?KO:K03580 OMA HHLVLFD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HHLVLFD PDB 3DMQ http://www.ebi.ac.uk/pdbe-srv/view/entry/3DMQ PDB 4S20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4S20 PDBsum 3DMQ http://www.ebi.ac.uk/pdbsum/3DMQ PDBsum 4S20 http://www.ebi.ac.uk/pdbsum/4S20 PROSITE PS51192 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51192 PROSITE PS51194 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51194 PSORT swissprot:RAPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RAPA_ECOLI PSORT-B swissprot:RAPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RAPA_ECOLI PSORT2 swissprot:RAPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RAPA_ECOLI Pfam PF00176 http://pfam.xfam.org/family/PF00176 Pfam PF00271 http://pfam.xfam.org/family/PF00271 Pfam PF12137 http://pfam.xfam.org/family/PF12137 Phobius swissprot:RAPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RAPA_ECOLI PhylomeDB P60240 http://phylomedb.org/?seqid=P60240 ProteinModelPortal P60240 http://www.proteinmodelportal.org/query/uniprot/P60240 PubMed 10801781 http://www.ncbi.nlm.nih.gov/pubmed/10801781 PubMed 11567013 http://www.ncbi.nlm.nih.gov/pubmed/11567013 PubMed 11751638 http://www.ncbi.nlm.nih.gov/pubmed/11751638 PubMed 1577702 http://www.ncbi.nlm.nih.gov/pubmed/1577702 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2034216 http://www.ncbi.nlm.nih.gov/pubmed/2034216 PubMed 8382805 http://www.ncbi.nlm.nih.gov/pubmed/8382805 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9507009 http://www.ncbi.nlm.nih.gov/pubmed/9507009 PubMed 9614128 http://www.ncbi.nlm.nih.gov/pubmed/9614128 RefSeq NP_414601 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414601 RefSeq WP_001117011 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001117011 SMART SM00487 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00487 SMART SM00490 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00490 SMR P60240 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P60240 STRING 511145.b0059 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0059&targetmode=cogs STRING COG0553 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0553&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB RAPA_ECOLI http://www.uniprot.org/uniprot/RAPA_ECOLI UniProtKB-AC P60240 http://www.uniprot.org/uniprot/P60240 charge swissprot:RAPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RAPA_ECOLI eggNOG COG0553 http://eggnogapi.embl.de/nog_data/html/tree/COG0553 eggNOG ENOG4105BZK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZK epestfind swissprot:RAPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RAPA_ECOLI garnier swissprot:RAPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RAPA_ECOLI helixturnhelix swissprot:RAPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RAPA_ECOLI hmoment swissprot:RAPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RAPA_ECOLI iep swissprot:RAPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RAPA_ECOLI inforesidue swissprot:RAPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RAPA_ECOLI octanol swissprot:RAPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RAPA_ECOLI pepcoil swissprot:RAPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RAPA_ECOLI pepdigest swissprot:RAPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RAPA_ECOLI pepinfo swissprot:RAPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RAPA_ECOLI pepnet swissprot:RAPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RAPA_ECOLI pepstats swissprot:RAPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RAPA_ECOLI pepwheel swissprot:RAPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RAPA_ECOLI pepwindow swissprot:RAPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RAPA_ECOLI sigcleave swissprot:RAPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RAPA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259355 153 # EcoGene EG13383 yeeO # FUNCTION YEEO_ECOLI A transporter able to export peptides and flavins. When overexpressed allows cells deleted for multiple peptidases (pepA, pepB, pepD and pepN) to grow in the presence of dipeptides Ala-Gln or Gly-Tyr which otherwise inhibit growth (PubMed 20067529). Cells overexpressing this protein have decreased intracellular levels of Ala-Gln dipeptide, and in a system that produces the Ala-Gln dipeptide, overproduction of this protein increases its export (PubMed 20067529). When overexpressed increases secretion of FMN and FAD but not riboflavin; intracellular concentrations of FMN and riboflavin rise, possibly to compensate for increased secretion (PubMed 25482085). Increased overexpression causes slight cell elongation (PubMed 25482085). {ECO 0000269|PubMed 20067529, ECO 0000269|PubMed 25482085}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015230 FAD transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0015238 drug transmembrane transporter activity; IBA:GO_Central. # GO_function GO:0015297 antiporter activity; IEA:InterPro. # GO_function GO:0044610 FMN transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0071916 dipeptide transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0006855 drug transmembrane transport; IBA:GO_Central. # GO_process GO:0015031 protein transport; IEA:UniProtKB-KW. # GO_process GO:0035350 FAD transmembrane transport; IDA:EcoCyc. # GO_process GO:0035442 dipeptide transmembrane transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # InterPro IPR002528 MATE_fam # Organism YEEO_ECOLI Escherichia coli (strain K12) # PATRIC 32119301 VBIEscCol129921_2062 # PIR B64963 B64963 # Pfam PF01554 MatE; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEEO_ECOLI Probable FMN/FAD exporter YeeO # RefSeq NP_416491 NC_000913.3 # SEQUENCE CAUTION Sequence=AAC75048.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. {ECO 0000305}. # SUBCELLULAR LOCATION YEEO_ECOLI Cell inner membrane {ECO 0000305}; Multi- pass membrane protein {ECO 0000305}. # TCDB 2.A.66.1.23 the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily # TIGRFAMs TIGR00797 matE # eggNOG COG0534 LUCA # eggNOG ENOG4105UQX Bacteria BLAST swissprot:YEEO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEEO_ECOLI BioCyc ECOL316407:JW1965-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1965-MONOMER BioCyc EcoCyc:YEEO-MONOMER http://biocyc.org/getid?id=EcoCyc:YEEO-MONOMER BioCyc MetaCyc:YEEO-MONOMER http://biocyc.org/getid?id=MetaCyc:YEEO-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1111/j.1574-6968.2009.01879.x http://dx.doi.org/10.1111/j.1574-6968.2009.01879.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.4161/21655979.2014.969173 http://dx.doi.org/10.4161/21655979.2014.969173 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3164 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3164 EcoGene EG13383 http://www.ecogene.org/geneInfo.php?eg_id=EG13383 EnsemblBacteria AAC75048 http://www.ensemblgenomes.org/id/AAC75048 EnsemblBacteria AAC75048 http://www.ensemblgenomes.org/id/AAC75048 EnsemblBacteria BAA15804 http://www.ensemblgenomes.org/id/BAA15804 EnsemblBacteria BAA15804 http://www.ensemblgenomes.org/id/BAA15804 EnsemblBacteria BAA15804 http://www.ensemblgenomes.org/id/BAA15804 EnsemblBacteria b1985 http://www.ensemblgenomes.org/id/b1985 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015230 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015230 GO_function GO:0015238 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015238 GO_function GO:0015297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015297 GO_function GO:0044610 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044610 GO_function GO:0071916 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071916 GO_process GO:0006855 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006855 GO_process GO:0015031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031 GO_process GO:0035350 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035350 GO_process GO:0035442 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035442 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 946506 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946506 HOGENOM HOG000056139 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000056139&db=HOGENOM6 InParanoid P76352 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76352 InterPro IPR002528 http://www.ebi.ac.uk/interpro/entry/IPR002528 KEGG_Gene ecj:JW1965 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1965 KEGG_Gene eco:b1985 http://www.genome.jp/dbget-bin/www_bget?eco:b1985 PSORT swissprot:YEEO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEEO_ECOLI PSORT-B swissprot:YEEO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEEO_ECOLI PSORT2 swissprot:YEEO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEEO_ECOLI Pfam PF01554 http://pfam.xfam.org/family/PF01554 Phobius swissprot:YEEO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEEO_ECOLI ProteinModelPortal P76352 http://www.proteinmodelportal.org/query/uniprot/P76352 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20067529 http://www.ncbi.nlm.nih.gov/pubmed/20067529 PubMed 25482085 http://www.ncbi.nlm.nih.gov/pubmed/25482085 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416491 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416491 STRING 511145.b1985 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1985&targetmode=cogs TCDB 2.A.66.1.23 http://www.tcdb.org/search/result.php?tc=2.A.66.1.23 TIGRFAMs TIGR00797 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00797 UniProtKB YEEO_ECOLI http://www.uniprot.org/uniprot/YEEO_ECOLI UniProtKB-AC P76352 http://www.uniprot.org/uniprot/P76352 charge swissprot:YEEO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEEO_ECOLI eggNOG COG0534 http://eggnogapi.embl.de/nog_data/html/tree/COG0534 eggNOG ENOG4105UQX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105UQX epestfind swissprot:YEEO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEEO_ECOLI garnier swissprot:YEEO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEEO_ECOLI helixturnhelix swissprot:YEEO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEEO_ECOLI hmoment swissprot:YEEO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEEO_ECOLI iep swissprot:YEEO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEEO_ECOLI inforesidue swissprot:YEEO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEEO_ECOLI octanol swissprot:YEEO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEEO_ECOLI pepcoil swissprot:YEEO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEEO_ECOLI pepdigest swissprot:YEEO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEEO_ECOLI pepinfo swissprot:YEEO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEEO_ECOLI pepnet swissprot:YEEO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEEO_ECOLI pepstats swissprot:YEEO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEEO_ECOLI pepwheel swissprot:YEEO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEEO_ECOLI pepwindow swissprot:YEEO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEEO_ECOLI sigcleave swissprot:YEEO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEEO_ECOLI ## Database ID URL or Descriptions # AltName EMRE_ECOLI Efflux-multidrug resistance protein EmrE # AltName EMRE_ECOLI Ethidium resistance protein # AltName EMRE_ECOLI Methyl viologen resistance protein C # BIOPHYSICOCHEMICAL PROPERTIES EMRE_ECOLI Kinetic parameters KM=247 uM for methyl viologen {ECO 0000269|PubMed 7896833}; Vmax=1572 nmol/min/mg enzyme with methyl viologen as substrate {ECO 0000269|PubMed 7896833}; pH dependence Optimum pH is 8-8.5. Transport activity occurs from pH 7.5 to 9. {ECO 0000269|PubMed 10681497}; # BioGrid 4259366 101 # CAUTION EM structures show an asymmetric dimer with the monomers in an antiparallel orientation, in contradiction with biochemical data and cross-linking studies, which demonstrated a parallel arrangement. Until now, EmrE with a parallel orientation is the only one to be shown to be fully functional. {ECO 0000305}. # EcoGene EG10629 emrE # FUNCTION EMRE_ECOLI Multidrug transporter that expels positively charged hydrophobic drugs across the inner membrane of E.coli., thereby conferring resistance to a wide range of toxic compounds. The drug efflux is coupled to an influx of protons. Is involved in the resistance of E.coli cells to methyl viologen, ethidium bromide and acriflavine. Is also able to transport tetraphenylphosphonium (TPP(+)) and benzalkonium. {ECO 0000269|PubMed 10681497, ECO 0000269|PubMed 11574548, ECO 0000269|PubMed 15371426, ECO 0000269|PubMed 7896833}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:EcoliWiki. # GO_component GO:0016021 integral component of membrane; IDA:EcoliWiki. # GO_function EMRE_ECOLI GO 0015307 drug proton antiporter activity; IDA EcoCyc. # GO_function GO:0015199 amino-acid betaine transmembrane transporter activity; IMP:EcoCyc. # GO_function GO:0015220 choline transmembrane transporter activity; IMP:EcoCyc. # GO_function GO:0015297 antiporter activity; IDA:EcoliWiki. # GO_function GO:0022857 transmembrane transporter activity; IDA:CACAO. # GO_process GO:0006805 xenobiotic metabolic process; IMP:EcoliWiki. # GO_process GO:0006810 transport; IDA:EcoliWiki. # GO_process GO:0006970 response to osmotic stress; IMP:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0015871 choline transport; IMP:EcoCyc. # GO_process GO:0031460 glycine betaine transport; IMP:EcoCyc. # GO_process GO:0042493 response to drug; IMP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # InterPro IPR000390 Small_multidrug_res # KEGG_Brite ko02000 Transporters # MISCELLANEOUS EMRE_ECOLI Encoded by the cryptic lambdoid prophage DLP12. # Organism EMRE_ECOLI Escherichia coli (strain K12) # PATRIC 32116248 VBIEscCol129921_0564 # PDB 2I68 EM; -; A/B=1-110 # PDB 3B5D X-ray; 3.80 A; A/B=1-110 # PDB 3B61 X-ray; 4.50 A; A/B/C/D/E/F/G/H=1-110 # PDB 3B62 X-ray; 4.40 A; A/B/C/D=1-110 # PIR JN0329 JN0329 # Pfam PF00893 Multi_Drug_Res # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EMRE_ECOLI Multidrug transporter EmrE # RefSeq NP_415075 NC_000913.3 # RefSeq WP_001070439 NZ_LN832404.1 # SIMILARITY Belongs to the small multidrug resistance (SMR) protein family. {ECO 0000305}. # SUBCELLULAR LOCATION EMRE_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT EMRE_ECOLI Homodimer; parallel. May also form dimer of homodimers. Binds substrate at the dimerization interface. {ECO 0000269|PubMed 14755055, ECO 0000269|PubMed 15111102, ECO 0000269|PubMed 15882076, ECO 0000269|PubMed 16373573, ECO 0000269|PubMed 17003034}. # TCDB 2.A.7.1 the drug/metabolite transporter (dmt) superfamily # eggNOG COG2076 LUCA # eggNOG ENOG410814C Bacteria BLAST swissprot:EMRE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EMRE_ECOLI BioCyc ECOL316407:JW0531-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0531-MONOMER BioCyc EcoCyc:EMRE-MONOMER http://biocyc.org/getid?id=EcoCyc:EMRE-MONOMER BioCyc MetaCyc:EMRE-MONOMER http://biocyc.org/getid?id=MetaCyc:EMRE-MONOMER COG COG2076 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2076 DIP DIP-9505N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9505N DOI 10.1016/0378-1097(91)90338-B http://dx.doi.org/10.1016/0378-1097(91)90338-B DOI 10.1016/S0014-5793(04)00228-5 http://dx.doi.org/10.1016/S0014-5793(04)00228-5 DOI 10.1016/S0014-5793(04)00240-6 http://dx.doi.org/10.1016/S0014-5793(04)00240-6 DOI 10.1016/j.jmb.2006.08.072 http://dx.doi.org/10.1016/j.jmb.2006.08.072 DOI 10.1021/bi050356t http://dx.doi.org/10.1021/bi050356t DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1432-1327.1998.2540610.x http://dx.doi.org/10.1046/j.1432-1327.1998.2540610.x DOI 10.1073/pnas.0306533101 http://dx.doi.org/10.1073/pnas.0306533101 DOI 10.1073/pnas.0400137101 http://dx.doi.org/10.1073/pnas.0400137101 DOI 10.1074/jbc.270.12.6856 http://dx.doi.org/10.1074/jbc.270.12.6856 DOI 10.1074/jbc.275.8.5264 http://dx.doi.org/10.1074/jbc.275.8.5264 DOI 10.1074/jbc.M108231200 http://dx.doi.org/10.1074/jbc.M108231200 DOI 10.1074/jbc.M213120200 http://dx.doi.org/10.1074/jbc.M213120200 DOI 10.1074/jbc.M408187200 http://dx.doi.org/10.1074/jbc.M408187200 DOI 10.1074/jbc.M504910200 http://dx.doi.org/10.1074/jbc.M504910200 DOI 10.1074/jbc.M602088200 http://dx.doi.org/10.1074/jbc.M602088200 DOI 10.1074/jbc.M607186200 http://dx.doi.org/10.1074/jbc.M607186200 DOI 10.1093/emboj/cdg611 http://dx.doi.org/10.1093/emboj/cdg611 DOI 10.1093/nar/20.12.3159 http://dx.doi.org/10.1093/nar/20.12.3159 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.1119776 http://dx.doi.org/10.1126/science.1119776 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1126/science.314.5807.1875b http://dx.doi.org/10.1126/science.314.5807.1875b EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M62732 http://www.ebi.ac.uk/ena/data/view/M62732 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EMBL Z11877 http://www.ebi.ac.uk/ena/data/view/Z11877 EchoBASE EB0623 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0623 EcoGene EG10629 http://www.ecogene.org/geneInfo.php?eg_id=EG10629 EnsemblBacteria AAC73644 http://www.ensemblgenomes.org/id/AAC73644 EnsemblBacteria AAC73644 http://www.ensemblgenomes.org/id/AAC73644 EnsemblBacteria BAE76318 http://www.ensemblgenomes.org/id/BAE76318 EnsemblBacteria BAE76318 http://www.ensemblgenomes.org/id/BAE76318 EnsemblBacteria BAE76318 http://www.ensemblgenomes.org/id/BAE76318 EnsemblBacteria b0543 http://www.ensemblgenomes.org/id/b0543 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015199 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015199 GO_function GO:0015220 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015220 GO_function GO:0015297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015297 GO_function GO:0015307 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015307 GO_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GO_process GO:0006805 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006805 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GO_process GO:0006970 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006970 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0015871 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015871 GO_process GO:0031460 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031460 GO_process GO:0042493 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 948442 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948442 HOGENOM HOG000268006 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000268006&db=HOGENOM6 InParanoid P23895 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23895 InterPro IPR000390 http://www.ebi.ac.uk/interpro/entry/IPR000390 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0531 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0531 KEGG_Gene eco:b0543 http://www.genome.jp/dbget-bin/www_bget?eco:b0543 KEGG_Orthology KO:K03297 http://www.genome.jp/dbget-bin/www_bget?KO:K03297 OMA YAIAFWM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YAIAFWM PDB 2I68 http://www.ebi.ac.uk/pdbe-srv/view/entry/2I68 PDB 3B5D http://www.ebi.ac.uk/pdbe-srv/view/entry/3B5D PDB 3B61 http://www.ebi.ac.uk/pdbe-srv/view/entry/3B61 PDB 3B62 http://www.ebi.ac.uk/pdbe-srv/view/entry/3B62 PDBsum 2I68 http://www.ebi.ac.uk/pdbsum/2I68 PDBsum 3B5D http://www.ebi.ac.uk/pdbsum/3B5D PDBsum 3B61 http://www.ebi.ac.uk/pdbsum/3B61 PDBsum 3B62 http://www.ebi.ac.uk/pdbsum/3B62 PSORT swissprot:EMRE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EMRE_ECOLI PSORT-B swissprot:EMRE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EMRE_ECOLI PSORT2 swissprot:EMRE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EMRE_ECOLI Pfam PF00893 http://pfam.xfam.org/family/PF00893 Phobius swissprot:EMRE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EMRE_ECOLI PhylomeDB P23895 http://phylomedb.org/?seqid=P23895 ProteinModelPortal P23895 http://www.proteinmodelportal.org/query/uniprot/P23895 PubMed 10681497 http://www.ncbi.nlm.nih.gov/pubmed/10681497 PubMed 11443233 http://www.ncbi.nlm.nih.gov/pubmed/11443233 PubMed 11574548 http://www.ncbi.nlm.nih.gov/pubmed/11574548 PubMed 12590142 http://www.ncbi.nlm.nih.gov/pubmed/12590142 PubMed 1320256 http://www.ncbi.nlm.nih.gov/pubmed/1320256 PubMed 14633977 http://www.ncbi.nlm.nih.gov/pubmed/14633977 PubMed 14755055 http://www.ncbi.nlm.nih.gov/pubmed/14755055 PubMed 14970332 http://www.ncbi.nlm.nih.gov/pubmed/14970332 PubMed 15044024 http://www.ncbi.nlm.nih.gov/pubmed/15044024 PubMed 15111102 http://www.ncbi.nlm.nih.gov/pubmed/15111102 PubMed 15371426 http://www.ncbi.nlm.nih.gov/pubmed/15371426 PubMed 15882076 http://www.ncbi.nlm.nih.gov/pubmed/15882076 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16049002 http://www.ncbi.nlm.nih.gov/pubmed/16049002 PubMed 16373573 http://www.ncbi.nlm.nih.gov/pubmed/16373573 PubMed 16672221 http://www.ncbi.nlm.nih.gov/pubmed/16672221 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17003034 http://www.ncbi.nlm.nih.gov/pubmed/17003034 PubMed 17005200 http://www.ncbi.nlm.nih.gov/pubmed/17005200 PubMed 17185584 http://www.ncbi.nlm.nih.gov/pubmed/17185584 PubMed 1936950 http://www.ncbi.nlm.nih.gov/pubmed/1936950 PubMed 7896833 http://www.ncbi.nlm.nih.gov/pubmed/7896833 PubMed 9050242 http://www.ncbi.nlm.nih.gov/pubmed/9050242 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9688273 http://www.ncbi.nlm.nih.gov/pubmed/9688273 RefSeq NP_415075 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415075 RefSeq WP_001070439 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001070439 SMR P23895 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P23895 STRING 511145.b0543 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0543&targetmode=cogs STRING COG2076 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2076&targetmode=cogs TCDB 2.A.7.1 http://www.tcdb.org/search/result.php?tc=2.A.7.1 UniProtKB EMRE_ECOLI http://www.uniprot.org/uniprot/EMRE_ECOLI UniProtKB-AC P23895 http://www.uniprot.org/uniprot/P23895 charge swissprot:EMRE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EMRE_ECOLI eggNOG COG2076 http://eggnogapi.embl.de/nog_data/html/tree/COG2076 eggNOG ENOG410814C http://eggnogapi.embl.de/nog_data/html/tree/ENOG410814C epestfind swissprot:EMRE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EMRE_ECOLI garnier swissprot:EMRE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EMRE_ECOLI helixturnhelix swissprot:EMRE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EMRE_ECOLI hmoment swissprot:EMRE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EMRE_ECOLI iep swissprot:EMRE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EMRE_ECOLI inforesidue swissprot:EMRE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EMRE_ECOLI octanol swissprot:EMRE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EMRE_ECOLI pepcoil swissprot:EMRE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EMRE_ECOLI pepdigest swissprot:EMRE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EMRE_ECOLI pepinfo swissprot:EMRE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EMRE_ECOLI pepnet swissprot:EMRE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EMRE_ECOLI pepstats swissprot:EMRE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EMRE_ECOLI pepwheel swissprot:EMRE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EMRE_ECOLI pepwindow swissprot:EMRE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EMRE_ECOLI sigcleave swissprot:EMRE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EMRE_ECOLI ## Database ID URL or Descriptions # BioGrid 4262493 190 # CATALYTIC ACTIVITY ATP + H(2)O + glycerol-3-phosphate(Out) = ADP + phosphate + glycerol-3-phosphate(In). {ECO:0000255|HAMAP- Rule MF_01727}. # ENZYME REGULATION Activated by gluconate, inhibited by fumarate and internal phosphate. Internal phosphate may bind to UgpC and reduce its affinity for UgpA and UgpE. {ECO:0000269|PubMed 363686}. # EcoGene EG11048 ugpC # FUNCTION UGPC_ECOLI Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system (Probable). Can also transport glycerophosphoryl diesters. {ECO 0000255|HAMAP-Rule MF_01727, ECO 0000269|PubMed 2842304, ECO 0000269|PubMed 363686, ECO 0000269|PubMed 7042685, ECO 0000269|PubMed 8282692, ECO 0000269|PubMed 8407831, ECO 0000305}. # GO_component GO:0055052 ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0015430 glycerol-3-phosphate-transporting ATPase activity; IEA:UniProtKB-HAMAP. # GO_process GO:0001407 glycerophosphodiester transport; IDA:EcoCyc. # GO_process GO:0008643 carbohydrate transport; IEA:UniProtKB-KW. # GO_process GO:0015794 glycerol-3-phosphate transport; IDA:EcoCyc. # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # Gene3D 3.40.50.300 -; 1. # INDUCTION UGPC_ECOLI Induced by phosphate starvation, via PhoB. Also induced by carbon starvation, via the cAMP receptor protein (CRP). {ECO 0000269|PubMed 1987150, ECO 0000269|PubMed 2842304, ECO 0000269|PubMed 7042685}. # IntAct P10907 8 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR008995 Mo/tungstate-bd_C_term_dom # InterPro IPR013611 Transp-assoc_OB_typ2 # InterPro IPR017871 ABC_transporter_CS # InterPro IPR017922 UgpC # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00198 Putative sn-glycerol-phosphate transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # MISCELLANEOUS UGPC_ECOLI Functional exchangeability of MalK and UgpC. But UgpC does not complement the regulatory function of MalK. # Organism UGPC_ECOLI Escherichia coli (strain K12) # PATRIC 32122340 VBIEscCol129921_3547 # PIR S47669 QRECUC # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # PROSITE PS51315 UGPC # Pfam PF00005 ABC_tran # Pfam PF08402 TOBE_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName sn-glycerol-3-phosphate import ATP-binding protein UgpC {ECO:0000255|HAMAP-Rule MF_01727} # RefSeq NP_417907 NC_000913.3 # RefSeq WP_000907792 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18425.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ABC transporter superfamily. sn- glycerol-3-phosphate importer (TC 3.A.1.1.3) family. {ECO:0000255|HAMAP-Rule MF_01727}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|HAMAP- Rule MF_01727}. # SMART SM00382 AAA # SUBCELLULAR LOCATION UGPC_ECOLI Cell inner membrane; Peripheral membrane protein. # SUBUNIT The complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute- binding protein (UgpB). {ECO:0000255|HAMAP-Rule MF_01727}. # SUPFAM SSF50331 SSF50331 # SUPFAM SSF52540 SSF52540 # TCDB 3.A.1.1 the atp-binding cassette (abc) superfamily # eggNOG COG3839 LUCA # eggNOG ENOG4108IJ9 Bacteria BLAST swissprot:UGPC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UGPC_ECOLI BioCyc ECOL316407:JW3415-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3415-MONOMER BioCyc EcoCyc:UGPC-MONOMER http://biocyc.org/getid?id=EcoCyc:UGPC-MONOMER BioCyc MetaCyc:UGPC-MONOMER http://biocyc.org/getid?id=MetaCyc:UGPC-MONOMER COG COG3839 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3839 DIP DIP-11079N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11079N DOI 10.1016/S0076-6879(98)92006-7 http://dx.doi.org/10.1016/S0076-6879(98)92006-7 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1111/j.1365-2958.1988.tb00088.x http://dx.doi.org/10.1111/j.1365-2958.1988.tb00088.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.3.20 {ECO:0000255|HAMAP-Rule:MF_01727} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.20 {ECO:0000255|HAMAP-Rule:MF_01727} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X13141 http://www.ebi.ac.uk/ena/data/view/X13141 ENZYME 3.6.3.20 {ECO:0000255|HAMAP-Rule:MF_01727} http://enzyme.expasy.org/EC/3.6.3.20 {ECO:0000255|HAMAP-Rule:MF_01727} EchoBASE EB1041 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1041 EcoGene EG11048 http://www.ecogene.org/geneInfo.php?eg_id=EG11048 EnsemblBacteria AAC76475 http://www.ensemblgenomes.org/id/AAC76475 EnsemblBacteria AAC76475 http://www.ensemblgenomes.org/id/AAC76475 EnsemblBacteria BAE77843 http://www.ensemblgenomes.org/id/BAE77843 EnsemblBacteria BAE77843 http://www.ensemblgenomes.org/id/BAE77843 EnsemblBacteria BAE77843 http://www.ensemblgenomes.org/id/BAE77843 EnsemblBacteria b3450 http://www.ensemblgenomes.org/id/b3450 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0055052 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055052 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0015430 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015430 GO_process GO:0001407 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001407 GO_process GO:0008643 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008643 GO_process GO:0015794 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015794 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947953 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947953 InParanoid P10907 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P10907 IntAct P10907 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P10907* IntEnz 3.6.3.20 {ECO:0000255|HAMAP-Rule:MF_01727} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.20 {ECO:0000255|HAMAP-Rule:MF_01727} InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR008995 http://www.ebi.ac.uk/interpro/entry/IPR008995 InterPro IPR013611 http://www.ebi.ac.uk/interpro/entry/IPR013611 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR017922 http://www.ebi.ac.uk/interpro/entry/IPR017922 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3415 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3415 KEGG_Gene eco:b3450 http://www.genome.jp/dbget-bin/www_bget?eco:b3450 KEGG_Orthology KO:K05816 http://www.genome.jp/dbget-bin/www_bget?KO:K05816 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA MTLPLEV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MTLPLEV PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PROSITE PS51315 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51315 PSORT swissprot:UGPC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UGPC_ECOLI PSORT-B swissprot:UGPC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UGPC_ECOLI PSORT2 swissprot:UGPC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UGPC_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Pfam PF08402 http://pfam.xfam.org/family/PF08402 Phobius swissprot:UGPC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UGPC_ECOLI PhylomeDB P10907 http://phylomedb.org/?seqid=P10907 ProteinModelPortal P10907 http://www.proteinmodelportal.org/query/uniprot/P10907 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1987150 http://www.ncbi.nlm.nih.gov/pubmed/1987150 PubMed 2842304 http://www.ncbi.nlm.nih.gov/pubmed/2842304 PubMed 3062310 http://www.ncbi.nlm.nih.gov/pubmed/3062310 PubMed 363686 http://www.ncbi.nlm.nih.gov/pubmed/363686 PubMed 7042685 http://www.ncbi.nlm.nih.gov/pubmed/7042685 PubMed 7836304 http://www.ncbi.nlm.nih.gov/pubmed/7836304 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 8282692 http://www.ncbi.nlm.nih.gov/pubmed/8282692 PubMed 8407831 http://www.ncbi.nlm.nih.gov/pubmed/8407831 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9711545 http://www.ncbi.nlm.nih.gov/pubmed/9711545 RefSeq NP_417907 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417907 RefSeq WP_000907792 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000907792 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P10907 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P10907 STRING 511145.b3450 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3450&targetmode=cogs STRING COG3839 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3839&targetmode=cogs SUPFAM SSF50331 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50331 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.1 http://www.tcdb.org/search/result.php?tc=3.A.1.1 UniProtKB UGPC_ECOLI http://www.uniprot.org/uniprot/UGPC_ECOLI UniProtKB-AC P10907 http://www.uniprot.org/uniprot/P10907 charge swissprot:UGPC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UGPC_ECOLI eggNOG COG3839 http://eggnogapi.embl.de/nog_data/html/tree/COG3839 eggNOG ENOG4108IJ9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108IJ9 epestfind swissprot:UGPC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UGPC_ECOLI garnier swissprot:UGPC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UGPC_ECOLI helixturnhelix swissprot:UGPC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UGPC_ECOLI hmoment swissprot:UGPC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UGPC_ECOLI iep swissprot:UGPC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UGPC_ECOLI inforesidue swissprot:UGPC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UGPC_ECOLI octanol swissprot:UGPC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UGPC_ECOLI pepcoil swissprot:UGPC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UGPC_ECOLI pepdigest swissprot:UGPC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UGPC_ECOLI pepinfo swissprot:UGPC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UGPC_ECOLI pepnet swissprot:UGPC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UGPC_ECOLI pepstats swissprot:UGPC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UGPC_ECOLI pepwheel swissprot:UGPC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UGPC_ECOLI pepwindow swissprot:UGPC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UGPC_ECOLI sigcleave swissprot:UGPC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UGPC_ECOLI ## Database ID URL or Descriptions # BioGrid 4260538 150 # DISRUPTION PHENOTYPE Mutation confers sensitivity to SDS-EDTA and leads to accumulation of phospholipid in the outer leaflet of the outer membrane. {ECO:0000269|PubMed 19383799}. # EcoGene EG14276 mlaA # FUNCTION MLAA_ECOLI Actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. {ECO 0000269|PubMed 19383799}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0009279 cell outer membrane; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # IntAct P76506 4 # InterPro IPR007428 MlaA # Organism MLAA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30035 PTHR30035 # PATRIC 32120065 VBIEscCol129921_2442 # PIR H65007 H65007 # PRINTS PR01805 VACJLIPOPROT # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF04333 MlaA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MLAA_ECOLI Probable phospholipid-binding lipoprotein MlaA # RefSeq NP_416848 NC_000913.3 # RefSeq WP_000776765 NZ_LN832404.1 # SIMILARITY Belongs to the MlaA family. {ECO 0000305}. # SUBCELLULAR LOCATION MLAA_ECOLI Cell outer membrane {ECO 0000305|PubMed 19383799}; Lipid-anchor {ECO 0000255|PROSITE- ProRule PRU00303, ECO 0000305|PubMed 19383799}. # TCDB 3.A.1.27 the atp-binding cassette (abc) superfamily # eggNOG COG2853 LUCA # eggNOG ENOG410903C Bacteria BLAST swissprot:MLAA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MLAA_ECOLI BioCyc ECOL316407:JW2343-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2343-MONOMER BioCyc EcoCyc:G7216-MONOMER http://biocyc.org/getid?id=EcoCyc:G7216-MONOMER COG COG2853 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2853 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0903229106 http://dx.doi.org/10.1073/pnas.0903229106 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4024 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4024 EcoGene EG14276 http://www.ecogene.org/geneInfo.php?eg_id=EG14276 EnsemblBacteria AAC75406 http://www.ensemblgenomes.org/id/AAC75406 EnsemblBacteria AAC75406 http://www.ensemblgenomes.org/id/AAC75406 EnsemblBacteria BAA16206 http://www.ensemblgenomes.org/id/BAA16206 EnsemblBacteria BAA16206 http://www.ensemblgenomes.org/id/BAA16206 EnsemblBacteria BAA16206 http://www.ensemblgenomes.org/id/BAA16206 EnsemblBacteria b2346 http://www.ensemblgenomes.org/id/b2346 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GeneID 945582 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945582 HOGENOM HOG000220801 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000220801&db=HOGENOM6 InParanoid P76506 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76506 IntAct P76506 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76506* InterPro IPR007428 http://www.ebi.ac.uk/interpro/entry/IPR007428 KEGG_Gene ecj:JW2343 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2343 KEGG_Gene eco:b2346 http://www.genome.jp/dbget-bin/www_bget?eco:b2346 KEGG_Orthology KO:K04754 http://www.genome.jp/dbget-bin/www_bget?KO:K04754 OMA FQRYDFL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FQRYDFL PANTHER PTHR30035 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30035 PRINTS PR01805 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01805 PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:MLAA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MLAA_ECOLI PSORT-B swissprot:MLAA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MLAA_ECOLI PSORT2 swissprot:MLAA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MLAA_ECOLI Pfam PF04333 http://pfam.xfam.org/family/PF04333 Phobius swissprot:MLAA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MLAA_ECOLI PhylomeDB P76506 http://phylomedb.org/?seqid=P76506 ProteinModelPortal P76506 http://www.proteinmodelportal.org/query/uniprot/P76506 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19383799 http://www.ncbi.nlm.nih.gov/pubmed/19383799 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416848 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416848 RefSeq WP_000776765 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000776765 STRING 511145.b2346 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2346&targetmode=cogs STRING COG2853 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2853&targetmode=cogs TCDB 3.A.1.27 http://www.tcdb.org/search/result.php?tc=3.A.1.27 UniProtKB MLAA_ECOLI http://www.uniprot.org/uniprot/MLAA_ECOLI UniProtKB-AC P76506 http://www.uniprot.org/uniprot/P76506 charge swissprot:MLAA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MLAA_ECOLI eggNOG COG2853 http://eggnogapi.embl.de/nog_data/html/tree/COG2853 eggNOG ENOG410903C http://eggnogapi.embl.de/nog_data/html/tree/ENOG410903C epestfind swissprot:MLAA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MLAA_ECOLI garnier swissprot:MLAA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MLAA_ECOLI helixturnhelix swissprot:MLAA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MLAA_ECOLI hmoment swissprot:MLAA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MLAA_ECOLI iep swissprot:MLAA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MLAA_ECOLI inforesidue swissprot:MLAA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MLAA_ECOLI octanol swissprot:MLAA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MLAA_ECOLI pepcoil swissprot:MLAA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MLAA_ECOLI pepdigest swissprot:MLAA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MLAA_ECOLI pepinfo swissprot:MLAA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MLAA_ECOLI pepnet swissprot:MLAA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MLAA_ECOLI pepstats swissprot:MLAA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MLAA_ECOLI pepwheel swissprot:MLAA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MLAA_ECOLI pepwindow swissprot:MLAA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MLAA_ECOLI sigcleave swissprot:MLAA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MLAA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261074 217 # EcoGene EG50001 rplU # FUNCTION RL21_ECOLI This protein binds to 23S rRNA in the presence of protein L20. {ECO 0000269|PubMed 2665813, ECO 0000269|PubMed 6170935}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0022625 cytosolic large ribosomal subunit; IDA:EcoCyc. # GO_function GO:0003735 structural constituent of ribosome; IBA:GO_Central. # GO_function GO:0019843 rRNA binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006412 translation; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_function GO:0019843 rRNA binding # GOslim_process GO:0006412 translation # HAMAP MF_01363 Ribosomal_L21 # IntAct P0AG48 81 # InterPro IPR001787 Ribosomal_L21 # InterPro IPR018258 Ribosomal_L21_CS # InterPro IPR028909 L21p-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=11562.7; Method=MALDI; Range=1-103; Evidence={ECO:0000269|PubMed 10094780}; # Organism RL21_ECOLI Escherichia coli (strain K12) # PATRIC 32121792 VBIEscCol129921_3280 # PDB 2J28 EM; 8.00 A; R=1-103 # PDB 2RDO EM; 9.10 A; R=1-103 # PDB 3BBX EM; 10.00 A; R=1-103 # PDB 3J5L EM; 6.60 A; R=1-103 # PDB 3J7Z EM; 3.90 A; R=1-103 # PDB 3J8G EM; 5.00 A; R=1-103 # PDB 3J9Y EM; 3.90 A; R=1-103 # PDB 3J9Z EM; 3.60 A; LP=1-103 # PDB 3JA1 EM; 3.60 A; LT=1-103 # PDB 3JBU EM; 3.64 A; r=1-103 # PDB 3JBV EM; 3.32 A; r=1-103 # PDB 3JCD EM; 3.70 A; R=1-103 # PDB 3JCE EM; 3.20 A; R=1-103 # PDB 3JCJ EM; 3.70 A; Q=1-103 # PDB 3JCN EM; 4.60 A; R=1-103 # PDB 4CSU EM; 5.50 A; R=1-103 # PDB 4U1U X-ray; 2.95 A; BR/DR=1-103 # PDB 4U1V X-ray; 3.00 A; BR/DR=1-103 # PDB 4U20 X-ray; 2.90 A; BR/DR=1-103 # PDB 4U24 X-ray; 2.90 A; BR/DR=1-103 # PDB 4U25 X-ray; 2.90 A; BR/DR=1-103 # PDB 4U26 X-ray; 2.80 A; BR/DR=1-103 # PDB 4U27 X-ray; 2.80 A; BR/DR=1-103 # PDB 4UY8 EM; 3.80 A; R=1-103 # PDB 4V4H X-ray; 3.46 A; BR/DR=1-103 # PDB 4V4Q X-ray; 3.46 A; BR/DR=1-103 # PDB 4V50 X-ray; 3.22 A; BR/DR=1-103 # PDB 4V52 X-ray; 3.21 A; BR/DR=1-103 # PDB 4V53 X-ray; 3.54 A; BR/DR=1-103 # PDB 4V54 X-ray; 3.30 A; BR/DR=1-103 # PDB 4V55 X-ray; 4.00 A; BR/DR=1-103 # PDB 4V56 X-ray; 3.93 A; BR/DR=1-103 # PDB 4V57 X-ray; 3.50 A; BR/DR=1-103 # PDB 4V5B X-ray; 3.74 A; AR/CR=1-103 # PDB 4V5H EM; 5.80 A; BR=1-103 # PDB 4V5Y X-ray; 4.45 A; BR/DR=1-103 # PDB 4V64 X-ray; 3.50 A; BR/DR=1-103 # PDB 4V65 EM; 9.00 A; BK=1-103 # PDB 4V66 EM; 9.00 A; BK=1-103 # PDB 4V69 EM; 6.70 A; BR=1-103 # PDB 4V6C X-ray; 3.19 A; BR/DR=1-103 # PDB 4V6D X-ray; 3.81 A; BR/DR=1-103 # PDB 4V6E X-ray; 3.71 A; BR/DR=1-103 # PDB 4V6K EM; 8.25 A; AS=1-103 # PDB 4V6L EM; 13.20 A; BS=1-103 # PDB 4V6M EM; 7.10 A; BR=1-103 # PDB 4V6N EM; 12.10 A; AT=1-103 # PDB 4V6O EM; 14.70 A; BT=1-103 # PDB 4V6P EM; 13.50 A; BT=1-103 # PDB 4V6Q EM; 11.50 A; BT=1-103 # PDB 4V6R EM; 11.50 A; BT=1-103 # PDB 4V6S EM; 13.10 A; AT=1-103 # PDB 4V6T EM; 8.30 A; BR=1-103 # PDB 4V6V EM; 9.80 A; BV=1-103 # PDB 4V6Y EM; 12.00 A; BR=1-103 # PDB 4V6Z EM; 12.00 A; BR=1-103 # PDB 4V70 EM; 17.00 A; BR=1-103 # PDB 4V71 EM; 20.00 A; BR=1-103 # PDB 4V72 EM; 13.00 A; BR=1-103 # PDB 4V73 EM; 15.00 A; BR=1-103 # PDB 4V74 EM; 17.00 A; BR=1-103 # PDB 4V75 EM; 12.00 A; BR=1-103 # PDB 4V76 EM; 17.00 A; BR=1-103 # PDB 4V77 EM; 17.00 A; BR=1-103 # PDB 4V78 EM; 20.00 A; BR=1-103 # PDB 4V79 EM; 15.00 A; BR=1-103 # PDB 4V7A EM; 9.00 A; BR=1-103 # PDB 4V7B EM; 6.80 A; BR=1-103 # PDB 4V7C EM; 7.60 A; BT=1-103 # PDB 4V7D EM; 7.60 A; AU=1-103 # PDB 4V7I EM; 9.60 A; AR=1-103 # PDB 4V7S X-ray; 3.25 A; BR/DR=1-103 # PDB 4V7T X-ray; 3.19 A; BR/DR=1-103 # PDB 4V7U X-ray; 3.10 A; BR/DR=1-103 # PDB 4V7V X-ray; 3.29 A; BR/DR=1-103 # PDB 4V85 X-ray; 3.20 A; V=1-103 # PDB 4V89 X-ray; 3.70 A; BV=1-103 # PDB 4V9C X-ray; 3.30 A; BR/DR=1-103 # PDB 4V9D X-ray; 3.00 A; CR/DR=1-103 # PDB 4V9O X-ray; 2.90 A; AR/CR/ER/GR=1-103 # PDB 4V9P X-ray; 2.90 A; AR/CR/ER/GR=1-103 # PDB 4WF1 X-ray; 3.09 A; BR/DR=1-103 # PDB 4WOI X-ray; 3.00 A; BR/CR=1-103 # PDB 4WWW X-ray; 3.10 A; RR/YR=1-103 # PDB 4YBB X-ray; 2.10 A; CS/DS=1-103 # PDB 5ADY EM; 4.50 A; R=1-103 # PDB 5AFI EM; 2.90 A; R=1-103 # PDB 5AKA EM; 5.70 A; R=1-103 # PDB 5GAD EM; 3.70 A; S=1-103 # PDB 5GAE EM; 3.33 A; S=1-103 # PDB 5GAF EM; 4.30 A; S=1-103 # PDB 5GAG EM; 3.80 A; S=1-103 # PDB 5GAH EM; 3.80 A; S=1-103 # PDB 5IQR EM; 3.00 A; R=1-103 # PDB 5IT8 X-ray; 3.12 A; CS/DS=1-103 # PDB 5J5B X-ray; 2.80 A; CS/DS=1-103 # PDB 5J7L X-ray; 3.00 A; CS/DS=1-103 # PDB 5J88 X-ray; 3.32 A; CS/DS=1-103 # PDB 5J8A X-ray; 3.10 A; CS/DS=1-103 # PDB 5J91 X-ray; 2.96 A; CS/DS=1-103 # PDB 5JC9 X-ray; 3.03 A; CS/DS=1-103 # PDB 5JTE EM; 3.60 A; BR=1-103 # PDB 5JU8 EM; 3.60 A; BR=1-103 # PDB 5KCR EM; 3.60 A; 1V=1-103 # PDB 5KCS EM; 3.90 A; 1V=1-103 # PDB 5KPS EM; 3.90 A; R=1-103 # PDB 5KPV EM; 4.10 A; Q=1-103 # PDB 5KPW EM; 3.90 A; Q=1-103 # PDB 5KPX EM; 3.90 A; Q=1-103 # PDB 5L3P EM; 3.70 A; V=1-103 # PIR JS0766 R5EC21 # PROSITE PS01169 RIBOSOMAL_L21 # Pfam PF00829 Ribosomal_L21p # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 50S ribosomal protein L21 {ECO:0000255|HAMAP-Rule MF_01363} # RefSeq NP_417653 NC_000913.3 # RefSeq WP_000271401 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein L21P family. {ECO:0000255|HAMAP-Rule MF_01363}. # SUBUNIT RL21_ECOLI Part of the 50S ribosomal subunit. Contacts protein L20. {ECO 0000269|PubMed 2665813, ECO 0000269|PubMed 6170935}. # SUPFAM SSF141091 SSF141091 # TIGRFAMs TIGR00061 L21 # eggNOG COG0261 LUCA BLAST swissprot:RL21_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RL21_ECOLI BioCyc ECOL316407:JW3153-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3153-MONOMER BioCyc EcoCyc:EG50001-MONOMER http://biocyc.org/getid?id=EcoCyc:EG50001-MONOMER BioCyc MetaCyc:EG50001-MONOMER http://biocyc.org/getid?id=MetaCyc:EG50001-MONOMER COG COG0261 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0261 DIP DIP-47852N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47852N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1016/j.celrep.2014.09.011 http://dx.doi.org/10.1016/j.celrep.2014.09.011 DOI 10.1021/bi00435a071 http://dx.doi.org/10.1021/bi00435a071 DOI 10.1021/bi00588a022 http://dx.doi.org/10.1021/bi00588a022 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/9.17.4285 http://dx.doi.org/10.1093/nar/9.17.4285 DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pbio.1001866 http://dx.doi.org/10.1371/journal.pbio.1001866 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D13267 http://www.ebi.ac.uk/ena/data/view/D13267 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB4295 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4295 EcoGene EG50001 http://www.ecogene.org/geneInfo.php?eg_id=EG50001 EnsemblBacteria AAC76218 http://www.ensemblgenomes.org/id/AAC76218 EnsemblBacteria AAC76218 http://www.ensemblgenomes.org/id/AAC76218 EnsemblBacteria BAE77230 http://www.ensemblgenomes.org/id/BAE77230 EnsemblBacteria BAE77230 http://www.ensemblgenomes.org/id/BAE77230 EnsemblBacteria BAE77230 http://www.ensemblgenomes.org/id/BAE77230 EnsemblBacteria b3186 http://www.ensemblgenomes.org/id/b3186 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0022625 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022625 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GeneID 949057 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949057 HAMAP MF_01363 http://hamap.expasy.org/unirule/MF_01363 HOGENOM HOG000036265 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000036265&db=HOGENOM6 InParanoid P0AG48 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AG48 IntAct P0AG48 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AG48* InterPro IPR001787 http://www.ebi.ac.uk/interpro/entry/IPR001787 InterPro IPR018258 http://www.ebi.ac.uk/interpro/entry/IPR018258 InterPro IPR028909 http://www.ebi.ac.uk/interpro/entry/IPR028909 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW3153 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3153 KEGG_Gene eco:b3186 http://www.genome.jp/dbget-bin/www_bget?eco:b3186 KEGG_Orthology KO:K02888 http://www.genome.jp/dbget-bin/www_bget?KO:K02888 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 MINT MINT-1280768 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1280768 OMA QGHRQPF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QGHRQPF PDB 2J28 http://www.ebi.ac.uk/pdbe-srv/view/entry/2J28 PDB 2RDO http://www.ebi.ac.uk/pdbe-srv/view/entry/2RDO PDB 3BBX http://www.ebi.ac.uk/pdbe-srv/view/entry/3BBX PDB 3J5L http://www.ebi.ac.uk/pdbe-srv/view/entry/3J5L PDB 3J7Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J7Z PDB 3J8G http://www.ebi.ac.uk/pdbe-srv/view/entry/3J8G PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 4CSU http://www.ebi.ac.uk/pdbe-srv/view/entry/4CSU PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4UY8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4UY8 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5ADY http://www.ebi.ac.uk/pdbe-srv/view/entry/5ADY PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5AKA http://www.ebi.ac.uk/pdbe-srv/view/entry/5AKA PDB 5GAD http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAD PDB 5GAE http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAE PDB 5GAF http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAF PDB 5GAG http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAG PDB 5GAH http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAH PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 2J28 http://www.ebi.ac.uk/pdbsum/2J28 PDBsum 2RDO http://www.ebi.ac.uk/pdbsum/2RDO PDBsum 3BBX http://www.ebi.ac.uk/pdbsum/3BBX PDBsum 3J5L http://www.ebi.ac.uk/pdbsum/3J5L PDBsum 3J7Z http://www.ebi.ac.uk/pdbsum/3J7Z PDBsum 3J8G http://www.ebi.ac.uk/pdbsum/3J8G PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 4CSU http://www.ebi.ac.uk/pdbsum/4CSU PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4UY8 http://www.ebi.ac.uk/pdbsum/4UY8 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5ADY http://www.ebi.ac.uk/pdbsum/5ADY PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5AKA http://www.ebi.ac.uk/pdbsum/5AKA PDBsum 5GAD http://www.ebi.ac.uk/pdbsum/5GAD PDBsum 5GAE http://www.ebi.ac.uk/pdbsum/5GAE PDBsum 5GAF http://www.ebi.ac.uk/pdbsum/5GAF PDBsum 5GAG http://www.ebi.ac.uk/pdbsum/5GAG PDBsum 5GAH http://www.ebi.ac.uk/pdbsum/5GAH PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PROSITE PS01169 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01169 PSORT swissprot:RL21_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RL21_ECOLI PSORT-B swissprot:RL21_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RL21_ECOLI PSORT2 swissprot:RL21_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RL21_ECOLI Pfam PF00829 http://pfam.xfam.org/family/PF00829 Phobius swissprot:RL21_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RL21_ECOLI PhylomeDB P0AG48 http://phylomedb.org/?seqid=P0AG48 ProteinModelPortal P0AG48 http://www.proteinmodelportal.org/query/uniprot/P0AG48 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 24844575 http://www.ncbi.nlm.nih.gov/pubmed/24844575 PubMed 25310980 http://www.ncbi.nlm.nih.gov/pubmed/25310980 PubMed 2665813 http://www.ncbi.nlm.nih.gov/pubmed/2665813 PubMed 387076 http://www.ncbi.nlm.nih.gov/pubmed/387076 PubMed 6170935 http://www.ncbi.nlm.nih.gov/pubmed/6170935 PubMed 8312607 http://www.ncbi.nlm.nih.gov/pubmed/8312607 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417653 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417653 RefSeq WP_000271401 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000271401 SMR P0AG48 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AG48 STRING 511145.b3186 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3186&targetmode=cogs STRING COG0261 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0261&targetmode=cogs SUPFAM SSF141091 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF141091 SWISS-2DPAGE P0AG48 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AG48 TIGRFAMs TIGR00061 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00061 UniProtKB RL21_ECOLI http://www.uniprot.org/uniprot/RL21_ECOLI UniProtKB-AC P0AG48 http://www.uniprot.org/uniprot/P0AG48 charge swissprot:RL21_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RL21_ECOLI eggNOG COG0261 http://eggnogapi.embl.de/nog_data/html/tree/COG0261 epestfind swissprot:RL21_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RL21_ECOLI garnier swissprot:RL21_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RL21_ECOLI helixturnhelix swissprot:RL21_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RL21_ECOLI hmoment swissprot:RL21_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RL21_ECOLI iep swissprot:RL21_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RL21_ECOLI inforesidue swissprot:RL21_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RL21_ECOLI octanol swissprot:RL21_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RL21_ECOLI pepcoil swissprot:RL21_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RL21_ECOLI pepdigest swissprot:RL21_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RL21_ECOLI pepinfo swissprot:RL21_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RL21_ECOLI pepnet swissprot:RL21_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RL21_ECOLI pepstats swissprot:RL21_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RL21_ECOLI pepwheel swissprot:RL21_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RL21_ECOLI pepwindow swissprot:RL21_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RL21_ECOLI sigcleave swissprot:RL21_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RL21_ECOLI ## Database ID URL or Descriptions # BioGrid 4260652 426 # DOMAIN FTSK_ECOLI Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains multimerise to produce a hexameric ring, contain the nucleotide binding motif and form the DNA pump. The gamma subdomain is a regulatory subdomain that controls translocation of DNA by recognition of KOPS motifs and interacts with XerD recombinase. {ECO 0000269|PubMed 15522074, ECO 0000269|PubMed 16553881, ECO 0000269|PubMed 19246541, ECO 0000269|PubMed 21091498, ECO 0000269|PubMed 21371996, ECO 0000269|PubMed 9829960}. # EcoGene EG13226 ftsK # FUNCTION FTSK_ECOLI Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif. Stoppage of translocation is accompanied by a reduction in ATPase activity. Also stimulates topoisomerase 4 activity. Required for the targeting of FtsQ, FtsL and FtsI to the septum. {ECO 0000269|PubMed 11703663, ECO 0000269|PubMed 11832210, ECO 0000269|PubMed 15522074, ECO 0000269|PubMed 16553881, ECO 0000269|PubMed 18363794, ECO 0000269|PubMed 19246541, ECO 0000269|PubMed 19854947, ECO 0000269|PubMed 20081205, ECO 0000269|PubMed 21371996, ECO 0000269|PubMed 9723913, ECO 0000269|PubMed 9829960}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:EcoliWiki. # GO_function GO:0003677 DNA binding; IDA:EcoliWiki. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0015616 DNA translocase activity; IDA:EcoCyc. # GO_function GO:0016887 ATPase activity; IDA:CACAO. # GO_function GO:0033676 double-stranded DNA-dependent ATPase activity; IMP:CACAO. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0043565 sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0000920 cell separation after cytokinesis; IMP:EcoliWiki. # GO_process GO:0006970 response to osmotic stress; IMP:EcoliWiki. # GO_process GO:0007049 cell cycle; IEA:UniProtKB-KW. # GO_process GO:0007059 chromosome segregation; IDA:EcoliWiki. # GO_process GO:0009651 response to salt stress; IMP:EcoliWiki. # GO_process GO:0043085 positive regulation of catalytic activity; IDA:EcoCyc. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IMP:EcoliWiki. # GO_process GO:0051301 cell division; IMP:CACAO. # GO_process GO:0071236 cellular response to antibiotic; IMP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0007049 cell cycle # GOslim_process GO:0007059 chromosome segregation # GOslim_process GO:0008150 biological_process # GOslim_process GO:0051301 cell division # Gene3D 3.40.50.300 -; 1. # INDUCTION Induced by DNA-damaging agents. {ECO:0000269|PubMed 9723913}. # INTERACTION FTSK_ECOLI P06136 ftsQ; NbExp=3; IntAct=EBI-550795, EBI-1130157; # IntAct P46889 7 # InterPro IPR002543 FtsK_dom # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR018541 Ftsk_gamma # InterPro IPR025199 FtsK_4TM # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko03036 Chromosome # Organism FTSK_ECOLI Escherichia coli (strain K12) # PATRIC 32116991 VBIEscCol129921_0920 # PDB 2IUS X-ray; 2.70 A; A/B/C/D/E/F=818-1329 # PDB 2J5P NMR; -; A=1261-1329 # PDB 5DCF X-ray; 2.30 A; A=1261-1329 # PIR A64828 A64828 # PROSITE PS50901 FTSK # Pfam PF01580 FtsK_SpoIIIE # Pfam PF09397 Ftsk_gamma # Pfam PF13491 FtsK_4TM # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FTSK_ECOLI DNA translocase FtsK # RefSeq NP_415410 NC_000913.3 # RefSeq WP_000076967 NZ_LN832404.1 # SIMILARITY Belongs to the FtsK/SpoIIIE/SftA family. {ECO 0000305}. # SIMILARITY Contains 1 FtsK domain. {ECO:0000255|PROSITE- ProRule PRU00289}. # SMART SM00843 Ftsk_gamma # SUBCELLULAR LOCATION FTSK_ECOLI Cell inner membrane {ECO 0000269|PubMed 11703663, ECO 0000269|PubMed 11948172, ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 25002583, ECO 0000269|PubMed 9723913}; Multi-pass membrane protein {ECO 0000269|PubMed 11703663, ECO 0000269|PubMed 11948172, ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 25002583, ECO 0000269|PubMed 9723913}. Note=Located at the septum. Colocalizes with FtsZ. ZipA, FtsZ and FtsA, but not FtsI and FtsQ are required to target it to the septum. # SUBUNIT FTSK_ECOLI Homohexamer. Forms a ring that surrounds DNA. Interacts with FtsZ, FtsQ, FtsL and FtsI. {ECO 0000269|PubMed 16553881, ECO 0000269|PubMed 16916635, ECO 0000269|PubMed 17185541, ECO 0000269|PubMed 18759781}. # SUPFAM SSF46785 SSF46785 # SUPFAM SSF52540 SSF52540 # TCDB 3.A.12.1 the septal dna translocator (s-dna-t) family # eggNOG COG1674 LUCA # eggNOG ENOG4105CNU Bacteria BLAST swissprot:FTSK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FTSK_ECOLI BioCyc ECOL316407:JW0873-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0873-MONOMER BioCyc EcoCyc:G6464-MONOMER http://biocyc.org/getid?id=EcoCyc:G6464-MONOMER COG COG1674 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1674 DIP DIP-9703N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9703N DOI 10.1002/cbic.201000347 http://dx.doi.org/10.1002/cbic.201000347 DOI 10.1016/S0014-5793(00)01820-2 http://dx.doi.org/10.1016/S0014-5793(00)01820-2 DOI 10.1016/S0092-8674(02)00624-4 http://dx.doi.org/10.1016/S0092-8674(02)00624-4 DOI 10.1016/j.molcel.2006.06.019 http://dx.doi.org/10.1016/j.molcel.2006.06.019 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsmb1158 http://dx.doi.org/10.1038/nsmb1158 DOI 10.1042/BST0380395 http://dx.doi.org/10.1042/BST0380395 DOI 10.1046/j.1365-2958.1998.00958.x http://dx.doi.org/10.1046/j.1365-2958.1998.00958.x DOI 10.1046/j.1365-2958.2001.02640.x http://dx.doi.org/10.1046/j.1365-2958.2001.02640.x DOI 10.1074/jbc.M114.569624 http://dx.doi.org/10.1074/jbc.M114.569624 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/nar/gkp104 http://dx.doi.org/10.1093/nar/gkp104 DOI 10.1093/nar/gkp1243 http://dx.doi.org/10.1093/nar/gkp1243 DOI 10.1093/nar/gkp843 http://dx.doi.org/10.1093/nar/gkp843 DOI 10.1093/nar/gkr078 http://dx.doi.org/10.1093/nar/gkr078 DOI 10.1099/mic.0.2006/000265-0 http://dx.doi.org/10.1099/mic.0.2006/000265-0 DOI 10.1111/j.1365-2958.2004.04335.x http://dx.doi.org/10.1111/j.1365-2958.2004.04335.x DOI 10.1111/j.1365-2958.2005.05033.x http://dx.doi.org/10.1111/j.1365-2958.2005.05033.x DOI 10.1111/j.1365-2958.2007.05755.x http://dx.doi.org/10.1111/j.1365-2958.2007.05755.x DOI 10.1111/j.1365-2958.2008.06212.x http://dx.doi.org/10.1111/j.1365-2958.2008.06212.x DOI 10.1111/j.1365-2958.2010.07412.x http://dx.doi.org/10.1111/j.1365-2958.2010.07412.x DOI 10.1111/j.1574-6968.2008.01317.x http://dx.doi.org/10.1111/j.1574-6968.2008.01317.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.9.2552-2556.2002 http://dx.doi.org/10.1128/JB.184.9.2552-2556.2002 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL Z49932 http://www.ebi.ac.uk/ena/data/view/Z49932 EchoBASE EB3016 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3016 EcoGene EG13226 http://www.ecogene.org/geneInfo.php?eg_id=EG13226 EnsemblBacteria AAC73976 http://www.ensemblgenomes.org/id/AAC73976 EnsemblBacteria AAC73976 http://www.ensemblgenomes.org/id/AAC73976 EnsemblBacteria BAA35615 http://www.ensemblgenomes.org/id/BAA35615 EnsemblBacteria BAA35615 http://www.ensemblgenomes.org/id/BAA35615 EnsemblBacteria BAA35615 http://www.ensemblgenomes.org/id/BAA35615 EnsemblBacteria b0890 http://www.ensemblgenomes.org/id/b0890 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0015616 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015616 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_function GO:0033676 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033676 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0000920 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000920 GO_process GO:0006970 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006970 GO_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GO_process GO:0007059 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007059 GO_process GO:0009651 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009651 GO_process GO:0043085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043085 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GO_process GO:0071236 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071236 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GOslim_process GO:0007059 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007059 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945102 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945102 HOGENOM HOG000010001 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000010001&db=HOGENOM6 InParanoid P46889 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P46889 IntAct P46889 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P46889* InterPro IPR002543 http://www.ebi.ac.uk/interpro/entry/IPR002543 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR018541 http://www.ebi.ac.uk/interpro/entry/IPR018541 InterPro IPR025199 http://www.ebi.ac.uk/interpro/entry/IPR025199 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene ecj:JW0873 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0873 KEGG_Gene eco:b0890 http://www.genome.jp/dbget-bin/www_bget?eco:b0890 KEGG_Orthology KO:K03466 http://www.genome.jp/dbget-bin/www_bget?KO:K03466 MINT MINT-1261773 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1261773 OMA DPFWKPG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DPFWKPG PDB 2IUS http://www.ebi.ac.uk/pdbe-srv/view/entry/2IUS PDB 2J5P http://www.ebi.ac.uk/pdbe-srv/view/entry/2J5P PDB 5DCF http://www.ebi.ac.uk/pdbe-srv/view/entry/5DCF PDBsum 2IUS http://www.ebi.ac.uk/pdbsum/2IUS PDBsum 2J5P http://www.ebi.ac.uk/pdbsum/2J5P PDBsum 5DCF http://www.ebi.ac.uk/pdbsum/5DCF PROSITE PS50901 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50901 PSORT swissprot:FTSK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FTSK_ECOLI PSORT-B swissprot:FTSK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FTSK_ECOLI PSORT2 swissprot:FTSK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FTSK_ECOLI Pfam PF01580 http://pfam.xfam.org/family/PF01580 Pfam PF09397 http://pfam.xfam.org/family/PF09397 Pfam PF13491 http://pfam.xfam.org/family/PF13491 Phobius swissprot:FTSK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FTSK_ECOLI ProteinModelPortal P46889 http://www.proteinmodelportal.org/query/uniprot/P46889 PubMed 10922461 http://www.ncbi.nlm.nih.gov/pubmed/10922461 PubMed 11703663 http://www.ncbi.nlm.nih.gov/pubmed/11703663 PubMed 11832210 http://www.ncbi.nlm.nih.gov/pubmed/11832210 PubMed 11948172 http://www.ncbi.nlm.nih.gov/pubmed/11948172 PubMed 15522074 http://www.ncbi.nlm.nih.gov/pubmed/15522074 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16553881 http://www.ncbi.nlm.nih.gov/pubmed/16553881 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16916635 http://www.ncbi.nlm.nih.gov/pubmed/16916635 PubMed 17057717 http://www.ncbi.nlm.nih.gov/pubmed/17057717 PubMed 17185541 http://www.ncbi.nlm.nih.gov/pubmed/17185541 PubMed 17511809 http://www.ncbi.nlm.nih.gov/pubmed/17511809 PubMed 18363794 http://www.ncbi.nlm.nih.gov/pubmed/18363794 PubMed 18759781 http://www.ncbi.nlm.nih.gov/pubmed/18759781 PubMed 19246541 http://www.ncbi.nlm.nih.gov/pubmed/19246541 PubMed 19854947 http://www.ncbi.nlm.nih.gov/pubmed/19854947 PubMed 20081205 http://www.ncbi.nlm.nih.gov/pubmed/20081205 PubMed 20298190 http://www.ncbi.nlm.nih.gov/pubmed/20298190 PubMed 20922738 http://www.ncbi.nlm.nih.gov/pubmed/20922738 PubMed 21091498 http://www.ncbi.nlm.nih.gov/pubmed/21091498 PubMed 21371996 http://www.ncbi.nlm.nih.gov/pubmed/21371996 PubMed 25002583 http://www.ncbi.nlm.nih.gov/pubmed/25002583 PubMed 7592387 http://www.ncbi.nlm.nih.gov/pubmed/7592387 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9723913 http://www.ncbi.nlm.nih.gov/pubmed/9723913 PubMed 9829960 http://www.ncbi.nlm.nih.gov/pubmed/9829960 RefSeq NP_415410 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415410 RefSeq WP_000076967 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000076967 SMART SM00843 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00843 SMR P46889 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P46889 STRING 511145.b0890 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0890&targetmode=cogs STRING COG1674 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1674&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.12.1 http://www.tcdb.org/search/result.php?tc=3.A.12.1 UniProtKB FTSK_ECOLI http://www.uniprot.org/uniprot/FTSK_ECOLI UniProtKB-AC P46889 http://www.uniprot.org/uniprot/P46889 charge swissprot:FTSK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FTSK_ECOLI eggNOG COG1674 http://eggnogapi.embl.de/nog_data/html/tree/COG1674 eggNOG ENOG4105CNU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CNU epestfind swissprot:FTSK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FTSK_ECOLI garnier swissprot:FTSK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FTSK_ECOLI helixturnhelix swissprot:FTSK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FTSK_ECOLI hmoment swissprot:FTSK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FTSK_ECOLI iep swissprot:FTSK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FTSK_ECOLI inforesidue swissprot:FTSK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FTSK_ECOLI octanol swissprot:FTSK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FTSK_ECOLI pepcoil swissprot:FTSK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FTSK_ECOLI pepdigest swissprot:FTSK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FTSK_ECOLI pepinfo swissprot:FTSK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FTSK_ECOLI pepnet swissprot:FTSK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FTSK_ECOLI pepstats swissprot:FTSK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FTSK_ECOLI pepwheel swissprot:FTSK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FTSK_ECOLI pepwindow swissprot:FTSK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FTSK_ECOLI sigcleave swissprot:FTSK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FTSK_ECOLI ## Database ID URL or Descriptions # BioGrid 4260533 252 # CATALYTIC ACTIVITY FADJ_ECOLI (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl- CoA + H(2)O. # CATALYTIC ACTIVITY FADJ_ECOLI (S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH. # CATALYTIC ACTIVITY FADJ_ECOLI (S)-3-hydroxybutanoyl-CoA = (R)-3- hydroxybutanoyl-CoA. # EcoGene EG14127 fadJ # FUNCTION FADJ_ECOLI Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities. Strongly involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate and weakly involved in the aerobic degradation of long-chain fatty acids. {ECO 0000269|PubMed 12270828, ECO 0000269|PubMed 12535077}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0004300 enoyl-CoA hydratase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0008692 3-hydroxybutyryl-CoA epimerase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0051287 NAD binding; IEA:InterPro. # GO_process GO:0006635 fatty acid beta-oxidation; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 1.10.1040.10 -; 2. # Gene3D 3.40.50.720 -; 1. # Gene3D 3.90.226.10 -; 1. # HAMAP MF_01617 FadJ # INDUCTION FADJ_ECOLI Unlike the aerobic pathway, the anaerobic pathway is not strongly repressed by FadR regulatory protein. # IntAct P77399 8 # InterPro IPR001753 Crotonase_core_superfam # InterPro IPR006108 3HC_DH_C # InterPro IPR006176 3-OHacyl-CoA_DH_NAD-bd # InterPro IPR006180 3-OHacyl-CoA_DH_CS # InterPro IPR008927 6-PGluconate_DH_C-like # InterPro IPR012802 FadJ # InterPro IPR013328 6PGD_dom_2 # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR029045 ClpP/crotonase-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00071 Fatty acid metabolism # KEGG_Pathway ko00280 Valine, leucine and isoleucine degradation # KEGG_Pathway ko00281 Geraniol degradation # KEGG_Pathway ko00310 Lysine degradation # KEGG_Pathway ko00380 Tryptophan metabolism # KEGG_Pathway ko00410 beta-Alanine metabolism # KEGG_Pathway ko00640 Propanoate metabolism # KEGG_Pathway ko00650 Butanoate metabolism # KEGG_Pathway ko00720 Carbon fixation pathways in prokaryotes # KEGG_Pathway ko00903 Limonene and pinene degradation # KEGG_Pathway ko00930 Caprolactam degradation # KEGG_Pathway ko01040 Biosynthesis of unsaturated fatty acids # Organism FADJ_ECOLI Escherichia coli (strain K12) # PATHWAY FADJ_ECOLI Lipid metabolism; fatty acid beta-oxidation. # PATRIC 32120055 VBIEscCol129921_2437 # PIR C65007 C65007 # PROSITE PS00067 3HCDH # Pfam PF00378 ECH_1 # Pfam PF00725 3HCDH; 2 # Pfam PF02737 3HCDH_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FADJ_ECOLI 3-hydroxyacyl-CoA dehydrogenase # RecName FADJ_ECOLI Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase # RecName FADJ_ECOLI Fatty acid oxidation complex subunit alpha # RecName FADJ_ECOLI Fatty acid oxidation complex subunit alpha # RefSeq NP_416843 NC_000913.3 # RefSeq WP_000426176 NZ_LN832404.1 # SIMILARITY In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. {ECO 0000305}. # SIMILARITY In the central section; belongs to the 3-hydroxyacyl- CoA dehydrogenase family. {ECO 0000305}. # SUBCELLULAR LOCATION FADJ_ECOLI Cytoplasm {ECO 0000250}. # SUBUNIT Heterotetramer of two alpha chains (FadJ) and two beta chains (FadI). {ECO 0000250}. # SUPFAM SSF48179 SSF48179; 2 # SUPFAM SSF51735 SSF51735 # SUPFAM SSF52096 SSF52096 # TIGRFAMs TIGR02440 FadJ # eggNOG COG1024 LUCA # eggNOG COG1250 LUCA # eggNOG ENOG4105DYT Bacteria BLAST swissprot:FADJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FADJ_ECOLI BioCyc ECOL316407:JW2338-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2338-MONOMER BioCyc EcoCyc:G7212-MONOMER http://biocyc.org/getid?id=EcoCyc:G7212-MONOMER BioCyc MetaCyc:G7212-MONOMER http://biocyc.org/getid?id=MetaCyc:G7212-MONOMER COG COG1024 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1024 COG COG1250 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1250 DIP DIP-11990N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11990N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2003.03341.x http://dx.doi.org/10.1046/j.1365-2958.2003.03341.x DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.20.5696-5705.2002 http://dx.doi.org/10.1128/JB.184.20.5696-5705.2002 EC_number EC:1.1.1.35 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.35 EC_number EC:4.2.1.17 http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.17 EC_number EC:5.1.2.3 http://www.genome.jp/dbget-bin/www_bget?EC:5.1.2.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.1.1.35 http://enzyme.expasy.org/EC/1.1.1.35 ENZYME 4.2.1.17 http://enzyme.expasy.org/EC/4.2.1.17 ENZYME 5.1.2.3 http://enzyme.expasy.org/EC/5.1.2.3 EchoBASE EB3879 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3879 EcoGene EG14127 http://www.ecogene.org/geneInfo.php?eg_id=EG14127 EnsemblBacteria AAC75401 http://www.ensemblgenomes.org/id/AAC75401 EnsemblBacteria AAC75401 http://www.ensemblgenomes.org/id/AAC75401 EnsemblBacteria BAA16195 http://www.ensemblgenomes.org/id/BAA16195 EnsemblBacteria BAA16195 http://www.ensemblgenomes.org/id/BAA16195 EnsemblBacteria BAA16195 http://www.ensemblgenomes.org/id/BAA16195 EnsemblBacteria b2341 http://www.ensemblgenomes.org/id/b2341 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003857 GO_function GO:0004300 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004300 GO_function GO:0008692 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008692 GO_function GO:0051287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051287 GO_process GO:0006635 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006635 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 1.10.1040.10 http://www.cathdb.info/version/latest/superfamily/1.10.1040.10 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 Gene3D 3.90.226.10 http://www.cathdb.info/version/latest/superfamily/3.90.226.10 GeneID 949097 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949097 HAMAP MF_01617 http://hamap.expasy.org/unirule/MF_01617 HOGENOM HOG000261346 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000261346&db=HOGENOM6 InParanoid P77399 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77399 IntAct P77399 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77399* IntEnz 1.1.1.35 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.35 IntEnz 4.2.1.17 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.17 IntEnz 5.1.2.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.1.2.3 InterPro IPR001753 http://www.ebi.ac.uk/interpro/entry/IPR001753 InterPro IPR006108 http://www.ebi.ac.uk/interpro/entry/IPR006108 InterPro IPR006176 http://www.ebi.ac.uk/interpro/entry/IPR006176 InterPro IPR006180 http://www.ebi.ac.uk/interpro/entry/IPR006180 InterPro IPR008927 http://www.ebi.ac.uk/interpro/entry/IPR008927 InterPro IPR012802 http://www.ebi.ac.uk/interpro/entry/IPR012802 InterPro IPR013328 http://www.ebi.ac.uk/interpro/entry/IPR013328 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR029045 http://www.ebi.ac.uk/interpro/entry/IPR029045 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2338 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2338 KEGG_Gene eco:b2341 http://www.genome.jp/dbget-bin/www_bget?eco:b2341 KEGG_Orthology KO:K01782 http://www.genome.jp/dbget-bin/www_bget?KO:K01782 KEGG_Pathway ko00071 http://www.genome.jp/kegg-bin/show_pathway?ko00071 KEGG_Pathway ko00280 http://www.genome.jp/kegg-bin/show_pathway?ko00280 KEGG_Pathway ko00281 http://www.genome.jp/kegg-bin/show_pathway?ko00281 KEGG_Pathway ko00310 http://www.genome.jp/kegg-bin/show_pathway?ko00310 KEGG_Pathway ko00380 http://www.genome.jp/kegg-bin/show_pathway?ko00380 KEGG_Pathway ko00410 http://www.genome.jp/kegg-bin/show_pathway?ko00410 KEGG_Pathway ko00640 http://www.genome.jp/kegg-bin/show_pathway?ko00640 KEGG_Pathway ko00650 http://www.genome.jp/kegg-bin/show_pathway?ko00650 KEGG_Pathway ko00720 http://www.genome.jp/kegg-bin/show_pathway?ko00720 KEGG_Pathway ko00903 http://www.genome.jp/kegg-bin/show_pathway?ko00903 KEGG_Pathway ko00930 http://www.genome.jp/kegg-bin/show_pathway?ko00930 KEGG_Pathway ko01040 http://www.genome.jp/kegg-bin/show_pathway?ko01040 KEGG_Reaction rn:R01975 http://www.genome.jp/dbget-bin/www_bget?rn:R01975 KEGG_Reaction rn:R03026 http://www.genome.jp/dbget-bin/www_bget?rn:R03026 KEGG_Reaction rn:R03045 http://www.genome.jp/dbget-bin/www_bget?rn:R03045 KEGG_Reaction rn:R03276 http://www.genome.jp/dbget-bin/www_bget?rn:R03276 KEGG_Reaction rn:R04137 http://www.genome.jp/dbget-bin/www_bget?rn:R04137 KEGG_Reaction rn:R04170 http://www.genome.jp/dbget-bin/www_bget?rn:R04170 KEGG_Reaction rn:R04203 http://www.genome.jp/dbget-bin/www_bget?rn:R04203 KEGG_Reaction rn:R04204 http://www.genome.jp/dbget-bin/www_bget?rn:R04204 KEGG_Reaction rn:R04224 http://www.genome.jp/dbget-bin/www_bget?rn:R04224 KEGG_Reaction rn:R04737 http://www.genome.jp/dbget-bin/www_bget?rn:R04737 KEGG_Reaction rn:R04738 http://www.genome.jp/dbget-bin/www_bget?rn:R04738 KEGG_Reaction rn:R04739 http://www.genome.jp/dbget-bin/www_bget?rn:R04739 KEGG_Reaction rn:R04740 http://www.genome.jp/dbget-bin/www_bget?rn:R04740 KEGG_Reaction rn:R04741 http://www.genome.jp/dbget-bin/www_bget?rn:R04741 KEGG_Reaction rn:R04744 http://www.genome.jp/dbget-bin/www_bget?rn:R04744 KEGG_Reaction rn:R04745 http://www.genome.jp/dbget-bin/www_bget?rn:R04745 KEGG_Reaction rn:R04746 http://www.genome.jp/dbget-bin/www_bget?rn:R04746 KEGG_Reaction rn:R04748 http://www.genome.jp/dbget-bin/www_bget?rn:R04748 KEGG_Reaction rn:R04749 http://www.genome.jp/dbget-bin/www_bget?rn:R04749 KEGG_Reaction rn:R05066 http://www.genome.jp/dbget-bin/www_bget?rn:R05066 KEGG_Reaction rn:R06411 http://www.genome.jp/dbget-bin/www_bget?rn:R06411 KEGG_Reaction rn:R06412 http://www.genome.jp/dbget-bin/www_bget?rn:R06412 KEGG_Reaction rn:R06941 http://www.genome.jp/dbget-bin/www_bget?rn:R06941 KEGG_Reaction rn:R06942 http://www.genome.jp/dbget-bin/www_bget?rn:R06942 KEGG_Reaction rn:R07951 http://www.genome.jp/dbget-bin/www_bget?rn:R07951 KEGG_Reaction rn:R08093 http://www.genome.jp/dbget-bin/www_bget?rn:R08093 KEGG_Reaction rn:R08094 http://www.genome.jp/dbget-bin/www_bget?rn:R08094 OMA MMMLNEA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MMMLNEA PROSITE PS00067 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00067 PSORT swissprot:FADJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FADJ_ECOLI PSORT-B swissprot:FADJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FADJ_ECOLI PSORT2 swissprot:FADJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FADJ_ECOLI Pfam PF00378 http://pfam.xfam.org/family/PF00378 Pfam PF00725 http://pfam.xfam.org/family/PF00725 Pfam PF02737 http://pfam.xfam.org/family/PF02737 Phobius swissprot:FADJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FADJ_ECOLI PhylomeDB P77399 http://phylomedb.org/?seqid=P77399 ProteinModelPortal P77399 http://www.proteinmodelportal.org/query/uniprot/P77399 PubMed 12270828 http://www.ncbi.nlm.nih.gov/pubmed/12270828 PubMed 12535077 http://www.ncbi.nlm.nih.gov/pubmed/12535077 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416843 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416843 RefSeq WP_000426176 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000426176 SMR P77399 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77399 STRING 511145.b2341 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2341&targetmode=cogs STRING COG1024 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1024&targetmode=cogs STRING COG1250 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1250&targetmode=cogs SUPFAM SSF48179 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48179 SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 SUPFAM SSF52096 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52096 TIGRFAMs TIGR02440 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02440 UniProtKB FADJ_ECOLI http://www.uniprot.org/uniprot/FADJ_ECOLI UniProtKB-AC P77399 http://www.uniprot.org/uniprot/P77399 charge swissprot:FADJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FADJ_ECOLI eggNOG COG1024 http://eggnogapi.embl.de/nog_data/html/tree/COG1024 eggNOG COG1250 http://eggnogapi.embl.de/nog_data/html/tree/COG1250 eggNOG ENOG4105DYT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DYT epestfind swissprot:FADJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FADJ_ECOLI garnier swissprot:FADJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FADJ_ECOLI helixturnhelix swissprot:FADJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FADJ_ECOLI hmoment swissprot:FADJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FADJ_ECOLI iep swissprot:FADJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FADJ_ECOLI inforesidue swissprot:FADJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FADJ_ECOLI octanol swissprot:FADJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FADJ_ECOLI pepcoil swissprot:FADJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FADJ_ECOLI pepdigest swissprot:FADJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FADJ_ECOLI pepinfo swissprot:FADJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FADJ_ECOLI pepnet swissprot:FADJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FADJ_ECOLI pepstats swissprot:FADJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FADJ_ECOLI pepwheel swissprot:FADJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FADJ_ECOLI pepwindow swissprot:FADJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FADJ_ECOLI sigcleave swissprot:FADJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FADJ_ECOLI ## Database ID URL or Descriptions # AltName Heme exporter protein A {ECO:0000255|HAMAP-Rule MF_01707} # BioGrid 4261550 10 # CATALYTIC ACTIVITY ATP + H(2)O + heme(In) = ADP + phosphate + heme(Out). {ECO:0000255|HAMAP-Rule MF_01707}. # EcoGene EG12059 ccmA # FUNCTION CCMA_ECOLI Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IEA:InterPro. # GO_component GO:0031234 extrinsic component of cytoplasmic side of plasma membrane; ISM:EcoCyc. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0015439 heme-transporting ATPase activity; IEA:UniProtKB-EC. # GO_function GO:0042623 ATPase activity, coupled; IMP:EcoCyc. # GO_function GO:0103115 protoheme IX ABC transporter activity; IEA:UniProtKB-EC. # GO_process GO:0015886 heme transport; IMP:EcoCyc. # GO_process GO:0017004 cytochrome complex assembly; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0006810 transport # Gene3D 3.40.50.300 -; 1. # IntAct P33931 3 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR005895 ABC_transptr_haem_export_CcmA # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00259 Heme transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism CCMA_ECOLI Escherichia coli (strain K12) # PATRIC 32119761 VBIEscCol129921_2290 # PIR G64989 G64989 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # PROSITE PS51243 CCMA # Pfam PF00005 ABC_tran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Cytochrome c biogenesis ATP-binding export protein CcmA {ECO:0000255|HAMAP-Rule MF_01707} # RefSeq NP_416705 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA16393.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. {ECO:0000255|HAMAP-Rule MF_01707}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|HAMAP- Rule MF_01707}. # SMART SM00382 AAA # SUBCELLULAR LOCATION CCMA_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01707}; Peripheral membrane protein {ECO 0000255|HAMAP- Rule MF_01707}. # SUBUNIT The complex is composed of two ATP-binding proteins (CcmA) and two transmembrane proteins (CcmB). {ECO:0000255|HAMAP- Rule MF_01707}. # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR01189 ccmA # eggNOG COG4133 LUCA # eggNOG ENOG4107EV4 Bacteria BLAST swissprot:CCMA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CCMA_ECOLI BioCyc ECOL316407:JW5366-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5366-MONOMER BioCyc EcoCyc:CCMA-MONOMER http://biocyc.org/getid?id=EcoCyc:CCMA-MONOMER BioCyc MetaCyc:CCMA-MONOMER http://biocyc.org/getid?id=MetaCyc:CCMA-MONOMER COG COG1131 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1131 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.96.11.6462 http://dx.doi.org/10.1073/pnas.96.11.6462 DOI 10.1099/00221287-146-2-527 http://dx.doi.org/10.1099/00221287-146-2-527 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.3.41 {ECO:0000255|HAMAP-Rule:MF_01707} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.41 {ECO:0000255|HAMAP-Rule:MF_01707} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00008 http://www.ebi.ac.uk/ena/data/view/U00008 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.6.3.41 {ECO:0000255|HAMAP-Rule:MF_01707} http://enzyme.expasy.org/EC/3.6.3.41 {ECO:0000255|HAMAP-Rule:MF_01707} EchoBASE EB1989 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1989 EcoGene EG12059 http://www.ecogene.org/geneInfo.php?eg_id=EG12059 EnsemblBacteria AAC75261 http://www.ensemblgenomes.org/id/AAC75261 EnsemblBacteria AAC75261 http://www.ensemblgenomes.org/id/AAC75261 EnsemblBacteria BAE76664 http://www.ensemblgenomes.org/id/BAE76664 EnsemblBacteria BAE76664 http://www.ensemblgenomes.org/id/BAE76664 EnsemblBacteria BAE76664 http://www.ensemblgenomes.org/id/BAE76664 EnsemblBacteria b2201 http://www.ensemblgenomes.org/id/b2201 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_component GO:0031234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031234 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0015439 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015439 GO_function GO:0042623 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042623 GO_function GO:0103115 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0103115 GO_process GO:0015886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015886 GO_process GO:0017004 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017004 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 946714 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946714 InParanoid P33931 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33931 IntAct P33931 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33931* IntEnz 3.6.3.41 {ECO:0000255|HAMAP-Rule:MF_01707} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.41 {ECO:0000255|HAMAP-Rule:MF_01707} InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR005895 http://www.ebi.ac.uk/interpro/entry/IPR005895 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5366 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5366 KEGG_Gene eco:b2201 http://www.genome.jp/dbget-bin/www_bget?eco:b2201 KEGG_Orthology KO:K02193 http://www.genome.jp/dbget-bin/www_bget?KO:K02193 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA RWDSEAI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RWDSEAI PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PROSITE PS51243 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51243 PSORT swissprot:CCMA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CCMA_ECOLI PSORT-B swissprot:CCMA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CCMA_ECOLI PSORT2 swissprot:CCMA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CCMA_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Phobius swissprot:CCMA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CCMA_ECOLI PhylomeDB P33931 http://phylomedb.org/?seqid=P33931 ProteinModelPortal P33931 http://www.proteinmodelportal.org/query/uniprot/P33931 PubMed 10339610 http://www.ncbi.nlm.nih.gov/pubmed/10339610 PubMed 10708391 http://www.ncbi.nlm.nih.gov/pubmed/10708391 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7635817 http://www.ncbi.nlm.nih.gov/pubmed/7635817 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416705 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416705 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 STRING 511145.b2201 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2201&targetmode=cogs STRING COG1131 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1131&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR01189 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01189 UniProtKB CCMA_ECOLI http://www.uniprot.org/uniprot/CCMA_ECOLI UniProtKB-AC P33931 http://www.uniprot.org/uniprot/P33931 charge swissprot:CCMA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CCMA_ECOLI eggNOG COG4133 http://eggnogapi.embl.de/nog_data/html/tree/COG4133 eggNOG ENOG4107EV4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107EV4 epestfind swissprot:CCMA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CCMA_ECOLI garnier swissprot:CCMA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CCMA_ECOLI helixturnhelix swissprot:CCMA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CCMA_ECOLI hmoment swissprot:CCMA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CCMA_ECOLI iep swissprot:CCMA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CCMA_ECOLI inforesidue swissprot:CCMA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CCMA_ECOLI octanol swissprot:CCMA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CCMA_ECOLI pepcoil swissprot:CCMA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CCMA_ECOLI pepdigest swissprot:CCMA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CCMA_ECOLI pepinfo swissprot:CCMA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CCMA_ECOLI pepnet swissprot:CCMA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CCMA_ECOLI pepstats swissprot:CCMA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CCMA_ECOLI pepwheel swissprot:CCMA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CCMA_ECOLI pepwindow swissprot:CCMA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CCMA_ECOLI sigcleave swissprot:CCMA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CCMA_ECOLI ## Database ID URL or Descriptions # AltName Exonuclease V subunit RecB {ECO:0000255|HAMAP-Rule MF_01485} # AltName Helicase/nuclease RecBCD subunit RecB {ECO:0000255|HAMAP-Rule MF_01485} # AltName RECB_ECOLI Exodeoxyribonuclease V 135 kDa polypeptide # AltName RECB_ECOLI Exodeoxyribonuclease V beta chain # BRENDA 3.1.11 2026 # BioGrid 4262307 585 # CATALYTIC ACTIVITY Exonucleolytic cleavage (in the presence of ATP) in either 5'- to 3'- or 3'- to 5'-direction to yield 5'- phosphooligonucleotides. {ECO:0000255|HAMAP-Rule MF_01485}. # COFACTOR RECB_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_01485, ECO 0000269|PubMed 15538360, ECO 0000269|PubMed 16388588, ECO 0000269|PubMed 18668125, ECO 0000305}; Note=Magnesium is required for both helicase and nuclease activity; its relative concentration alters helicase speed and nuclease activity in a complicated fashion. {ECO 0000255|HAMAP- Rule MF_01485, ECO 0000269|PubMed 15538360, ECO 0000269|PubMed 16388588, ECO 0000269|PubMed 18668125, ECO 0000305}; # DISRUPTION PHENOTYPE RECB_ECOLI Decreased degradation of DNA with free ends that is unable to undergo homologous recombination, which can fortuitously lead to more efficient viral infection (PubMed 4562392, PubMed 123277). Cells are deficient in DNA recombination repair and have increased sensitivity to UV light. The cultures have many inviable cells. {ECO 0000269|PubMed 123277, ECO 0000269|PubMed 4562392, ECO 0000269|PubMed 6389498}. # DOMAIN RECB_ECOLI The N-terminal DNA-binding domain (residues 1-929) is a ssDNA-dependent ATPase and has ATP-dependent 3'-5' helicase function; both are stimulated in the presence of RecC, suggesting this domain interacts with RecC. Holoenzyme reconstituted with this RecB N-terminal fragment has no nuclease activity (PubMed 9448271). The C-terminal domain (residues 928-1180) has weak ssDNA endonuclease activity as an isolated fragment (PubMed 9790841) (PubMed 10518611). RecD probably interacts with this domain. The C-terminal domain interacts with RecA, facilitating its loading onto ssDNA. Interaction is decreased by ATP (PubMed 16483938). {ECO 0000269|PubMed 10518611, ECO 0000269|PubMed 16483938, ECO 0000269|PubMed 9448271, ECO 0000269|PubMed 9790841}. # DOMAIN RECB_ECOLI The holoenzyme may undergo conformational shifts upon DNA binding the nuclease domain of RecB may swing away from the DNA exit tunnel in RecC. When Chi DNA binds to the RecC tunnel, the nuclease domain may then swing back to its original position (that seen in crystal structures), allowing it to nick the DNA 3' of the Chi site and then rotate to load RecA. At high Mg(2+) the nuclease domain may swing back more frequently, explaining differences seen in assays performed at high Mg(2+). {ECO 0000269|PubMed 25073102}. # ENZYME REGULATION RECB_ECOLI After reacting with DNA bearing a Chi site the holoenzyme is disassembled and loses exonuclease activity, DNA unwinding and Chi-directed DNA cleavage; RecB remains complexed with ssDNA, which may prevent holoenzyme reassembly (PubMed 10197988). High levels of Mg(2+) (13 mM MgCl(2+)) or incubation with DNase allow holoenyzme reassembly, suggesting it is DNA bound to RecB that prevents reassembly (PubMed 10197988). {ECO 0000269|PubMed 10197988, ECO 0000269|PubMed 1535156}. # EcoGene EG10824 recB # FUNCTION RECB_ECOLI A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a rapid (>1 kb/second) and highly processive (>30 kb) ATP-dependent bidirectional helicase. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator, 5'-GCTGGTGG-3') sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to Chi site, by nicking one strand or switching the strand degraded (depending on the reaction conditions). The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang which facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination (PubMed 4562392, PubMed 4552016, PubMed 123277). In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA. The RecBC complex requires the RecD subunit for nuclease activity, but can translocate along ssDNA in both directions. {ECO 0000269|PubMed 10197988, ECO 0000269|PubMed 10518611, ECO 0000269|PubMed 10766864, ECO 0000269|PubMed 123277, ECO 0000269|PubMed 12815437, ECO 0000269|PubMed 12815438, ECO 0000269|PubMed 1535156, ECO 0000269|PubMed 16041061, ECO 0000269|PubMed 1618858, ECO 0000269|PubMed 16388588, ECO 0000269|PubMed 18079176, ECO 0000269|PubMed 20852646, ECO 0000269|PubMed 23851395, ECO 0000269|PubMed 25073102, ECO 0000269|PubMed 4268693, ECO 0000269|PubMed 4552016, ECO 0000269|PubMed 4562392, ECO 0000269|PubMed 7608206, ECO 0000269|PubMed 9192629, ECO 0000269|PubMed 9230304, ECO 0000269|PubMed 9448271, ECO 0000269|PubMed 9790841}. # GO_component GO:0009338 exodeoxyribonuclease V complex; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0004003 ATP-dependent DNA helicase activity; IDA:EcoCyc. # GO_function GO:0004519 endonuclease activity; IMP:EcoCyc. # GO_function GO:0005524 ATP binding; IDA:EcoliWiki. # GO_function GO:0008854 exodeoxyribonuclease V activity; IMP:EcoCyc. # GO_process GO:0000724 double-strand break repair via homologous recombination; IEA:UniProtKB-HAMAP. # GO_process GO:0006302 double-strand break repair; IDA:EcoCyc. # GO_process GO:0006310 DNA recombination; IMP:EcoCyc. # GO_process GO:0044355 clearance of foreign intracellular DNA; IMP:UniProtKB. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004386 helicase activity # GOslim_function GO:0004518 nuclease activity # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # Gene3D 3.40.50.300 -; 5. # Gene3D 3.90.320.10 -; 1. # HAMAP MF_01485 RecB # IntAct P08394 19 # InterPro IPR000212 DNA_helicase_UvrD/REP # InterPro IPR004586 RecB # InterPro IPR011335 Restrct_endonuc-II-like # InterPro IPR011604 Exonuc_phg/RecB_C # InterPro IPR014016 UvrD-like_ATP-bd # InterPro IPR014017 DNA_helicase_UvrD-like_C # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko03440 Homologous recombination # Organism RECB_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11070 PTHR11070; 4 # PATRIC 32121058 VBIEscCol129921_2918 # PDB 1W36 X-ray; 3.10 A; B/E=1-1180 # PDB 3K70 X-ray; 3.59 A; B/E=1-1180 # PDB 5LD2 EM; 3.83 A; B=1-912, B=938-1180 # PIR A25532 NCECX5 # PROSITE PS51198 UVRD_HELICASE_ATP_BIND # PROSITE PS51217 UVRD_HELICASE_CTER # Pfam PF00580 UvrD-helicase # Pfam PF13361 UvrD_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RecBCD enzyme subunit RecB {ECO:0000255|HAMAP-Rule MF_01485} # RefSeq NP_417297 NC_000913.3 # RefSeq WP_001285993 NZ_LN832404.1 # SIMILARITY Belongs to the helicase family. UvrD subfamily. {ECO:0000255|HAMAP-Rule MF_01485}. # SIMILARITY Contains 1 uvrD-like helicase ATP-binding domain. {ECO:0000255|HAMAP-Rule MF_01485}. # SIMILARITY Contains 1 uvrD-like helicase C-terminal domain. {ECO:0000255|HAMAP-Rule MF_01485}. # SUBUNIT RECB_ECOLI Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding. The C-terminus interacts with RecA (PubMed 16483938). Interacts with YgbT (Cas1) (PubMed 21219465). {ECO 0000269|PubMed 15538360, ECO 0000269|PubMed 1618858, ECO 0000269|PubMed 16483938, ECO 0000269|PubMed 18668125, ECO 0000269|PubMed 21219465, ECO 0000269|PubMed 3526335, ECO 0000269|PubMed 4552016, ECO 0000269|PubMed 9448271}. # SUPFAM SSF52540 SSF52540; 3 # SUPFAM SSF52980 SSF52980 # TIGRFAMs TIGR00609 recB # eggNOG COG1074 LUCA # eggNOG ENOG4107QKA Bacteria BLAST swissprot:RECB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RECB_ECOLI BioCyc ECOL316407:JW2788-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2788-MONOMER BioCyc EcoCyc:EG10824-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10824-MONOMER BioCyc MetaCyc:EG10824-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10824-MONOMER COG COG1074 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1074 DIP DIP-540N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-540N DOI 10.1006/jmbi.1998.2127 http://dx.doi.org/10.1006/jmbi.1998.2127 DOI 10.1016/S0092-8674(00)80315-3 http://dx.doi.org/10.1016/S0092-8674(00)80315-3 DOI 10.1016/j.jmb.2014.07.017 http://dx.doi.org/10.1016/j.jmb.2014.07.017 DOI 10.1016/j.molcel.2006.01.007 http://dx.doi.org/10.1016/j.molcel.2006.01.007 DOI 10.1021/bi051150v http://dx.doi.org/10.1021/bi051150v DOI 10.1038/emboj.2008.144 http://dx.doi.org/10.1038/emboj.2008.144 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature01673 http://dx.doi.org/10.1038/nature01673 DOI 10.1038/nature01674 http://dx.doi.org/10.1038/nature01674 DOI 10.1038/nature02988 http://dx.doi.org/10.1038/nature02988 DOI 10.1038/nature12333 http://dx.doi.org/10.1038/nature12333 DOI 10.1038/nsmb.1901 http://dx.doi.org/10.1038/nsmb.1901 DOI 10.1073/pnas.83.15.5558 http://dx.doi.org/10.1073/pnas.83.15.5558 DOI 10.1073/pnas.89.12.5226 http://dx.doi.org/10.1073/pnas.89.12.5226 DOI 10.1073/pnas.94.13.6706 http://dx.doi.org/10.1073/pnas.94.13.6706 DOI 10.1073/pnas.95.3.981 http://dx.doi.org/10.1073/pnas.95.3.981 DOI 10.1074/jbc.270.27.16360 http://dx.doi.org/10.1074/jbc.270.27.16360 DOI 10.1074/jbc.275.16.12261 http://dx.doi.org/10.1074/jbc.275.16.12261 DOI 10.1074/jbc.M505520200 http://dx.doi.org/10.1074/jbc.M505520200 DOI 10.1093/nar/14.19.7695 http://dx.doi.org/10.1093/nar/14.19.7695 DOI 10.1093/nar/14.21.8573 http://dx.doi.org/10.1093/nar/14.21.8573 DOI 10.1093/nar/14.21.8583 http://dx.doi.org/10.1093/nar/14.21.8583 DOI 10.1093/nar/27.21.4200 http://dx.doi.org/10.1093/nar/27.21.4200 DOI 10.1101/gad.13.7.890 http://dx.doi.org/10.1101/gad.13.7.890 DOI 10.1101/gad.1605807 http://dx.doi.org/10.1101/gad.1605807 DOI 10.1111/j.1365-2958.2010.07465.x http://dx.doi.org/10.1111/j.1365-2958.2010.07465.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/MMBR.00020-08 http://dx.doi.org/10.1128/MMBR.00020-08 DOI 10.1128/MMBR.05026-11 http://dx.doi.org/10.1128/MMBR.05026-11 EC_number EC:3.1.11.5 {ECO:0000255|HAMAP-Rule:MF_01485} http://www.genome.jp/dbget-bin/www_bget?EC:3.1.11.5 {ECO:0000255|HAMAP-Rule:MF_01485} EMBL AF179304 http://www.ebi.ac.uk/ena/data/view/AF179304 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 EMBL X04581 http://www.ebi.ac.uk/ena/data/view/X04581 EMBL X04582 http://www.ebi.ac.uk/ena/data/view/X04582 EMBL X06227 http://www.ebi.ac.uk/ena/data/view/X06227 ENZYME 3.1.11.5 {ECO:0000255|HAMAP-Rule:MF_01485} http://enzyme.expasy.org/EC/3.1.11.5 {ECO:0000255|HAMAP-Rule:MF_01485} EchoBASE EB0817 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0817 EcoGene EG10824 http://www.ecogene.org/geneInfo.php?eg_id=EG10824 EnsemblBacteria AAC75859 http://www.ensemblgenomes.org/id/AAC75859 EnsemblBacteria AAC75859 http://www.ensemblgenomes.org/id/AAC75859 EnsemblBacteria BAE76889 http://www.ensemblgenomes.org/id/BAE76889 EnsemblBacteria BAE76889 http://www.ensemblgenomes.org/id/BAE76889 EnsemblBacteria BAE76889 http://www.ensemblgenomes.org/id/BAE76889 EnsemblBacteria b2820 http://www.ensemblgenomes.org/id/b2820 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009338 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009338 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004003 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004003 GO_function GO:0004519 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004519 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008854 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008854 GO_process GO:0000724 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000724 GO_process GO:0006302 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006302 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0044355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044355 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004386 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 Gene3D 3.90.320.10 http://www.cathdb.info/version/latest/superfamily/3.90.320.10 GeneID 947286 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947286 HAMAP MF_01485 http://hamap.expasy.org/unirule/MF_01485 HOGENOM HOG000258330 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000258330&db=HOGENOM6 InParanoid P08394 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P08394 IntAct P08394 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P08394* IntEnz 3.1.11.5 {ECO:0000255|HAMAP-Rule:MF_01485} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.11.5 {ECO:0000255|HAMAP-Rule:MF_01485} InterPro IPR000212 http://www.ebi.ac.uk/interpro/entry/IPR000212 InterPro IPR004586 http://www.ebi.ac.uk/interpro/entry/IPR004586 InterPro IPR011335 http://www.ebi.ac.uk/interpro/entry/IPR011335 InterPro IPR011604 http://www.ebi.ac.uk/interpro/entry/IPR011604 InterPro IPR014016 http://www.ebi.ac.uk/interpro/entry/IPR014016 InterPro IPR014017 http://www.ebi.ac.uk/interpro/entry/IPR014017 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW2788 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2788 KEGG_Gene eco:b2820 http://www.genome.jp/dbget-bin/www_bget?eco:b2820 KEGG_Orthology KO:K03582 http://www.genome.jp/dbget-bin/www_bget?KO:K03582 KEGG_Pathway ko03440 http://www.genome.jp/kegg-bin/show_pathway?ko03440 MINT MINT-1224378 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1224378 OMA IMIGDPK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IMIGDPK PANTHER PTHR11070 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11070 PDB 1W36 http://www.ebi.ac.uk/pdbe-srv/view/entry/1W36 PDB 3K70 http://www.ebi.ac.uk/pdbe-srv/view/entry/3K70 PDB 5LD2 http://www.ebi.ac.uk/pdbe-srv/view/entry/5LD2 PDBsum 1W36 http://www.ebi.ac.uk/pdbsum/1W36 PDBsum 3K70 http://www.ebi.ac.uk/pdbsum/3K70 PDBsum 5LD2 http://www.ebi.ac.uk/pdbsum/5LD2 PROSITE PS51198 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51198 PROSITE PS51217 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51217 PSORT swissprot:RECB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RECB_ECOLI PSORT-B swissprot:RECB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RECB_ECOLI PSORT2 swissprot:RECB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RECB_ECOLI Pfam PF00580 http://pfam.xfam.org/family/PF00580 Pfam PF13361 http://pfam.xfam.org/family/PF13361 Phobius swissprot:RECB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RECB_ECOLI PhylomeDB P08394 http://phylomedb.org/?seqid=P08394 ProteinModelPortal P08394 http://www.proteinmodelportal.org/query/uniprot/P08394 PubMed 10197988 http://www.ncbi.nlm.nih.gov/pubmed/10197988 PubMed 10518611 http://www.ncbi.nlm.nih.gov/pubmed/10518611 PubMed 10766864 http://www.ncbi.nlm.nih.gov/pubmed/10766864 PubMed 123277 http://www.ncbi.nlm.nih.gov/pubmed/123277 PubMed 12815437 http://www.ncbi.nlm.nih.gov/pubmed/12815437 PubMed 12815438 http://www.ncbi.nlm.nih.gov/pubmed/12815438 PubMed 1535156 http://www.ncbi.nlm.nih.gov/pubmed/1535156 PubMed 15538360 http://www.ncbi.nlm.nih.gov/pubmed/15538360 PubMed 16041061 http://www.ncbi.nlm.nih.gov/pubmed/16041061 PubMed 1618858 http://www.ncbi.nlm.nih.gov/pubmed/1618858 PubMed 16388588 http://www.ncbi.nlm.nih.gov/pubmed/16388588 PubMed 16483938 http://www.ncbi.nlm.nih.gov/pubmed/16483938 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18079176 http://www.ncbi.nlm.nih.gov/pubmed/18079176 PubMed 18668125 http://www.ncbi.nlm.nih.gov/pubmed/18668125 PubMed 19052323 http://www.ncbi.nlm.nih.gov/pubmed/19052323 PubMed 20852646 http://www.ncbi.nlm.nih.gov/pubmed/20852646 PubMed 21219465 http://www.ncbi.nlm.nih.gov/pubmed/21219465 PubMed 22688812 http://www.ncbi.nlm.nih.gov/pubmed/22688812 PubMed 23851395 http://www.ncbi.nlm.nih.gov/pubmed/23851395 PubMed 25073102 http://www.ncbi.nlm.nih.gov/pubmed/25073102 PubMed 3526335 http://www.ncbi.nlm.nih.gov/pubmed/3526335 PubMed 3534791 http://www.ncbi.nlm.nih.gov/pubmed/3534791 PubMed 3537960 http://www.ncbi.nlm.nih.gov/pubmed/3537960 PubMed 3537961 http://www.ncbi.nlm.nih.gov/pubmed/3537961 PubMed 4268693 http://www.ncbi.nlm.nih.gov/pubmed/4268693 PubMed 4552016 http://www.ncbi.nlm.nih.gov/pubmed/4552016 PubMed 4562392 http://www.ncbi.nlm.nih.gov/pubmed/4562392 PubMed 6389498 http://www.ncbi.nlm.nih.gov/pubmed/6389498 PubMed 7608206 http://www.ncbi.nlm.nih.gov/pubmed/7608206 PubMed 9192629 http://www.ncbi.nlm.nih.gov/pubmed/9192629 PubMed 9230304 http://www.ncbi.nlm.nih.gov/pubmed/9230304 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9448271 http://www.ncbi.nlm.nih.gov/pubmed/9448271 PubMed 9790841 http://www.ncbi.nlm.nih.gov/pubmed/9790841 RefSeq NP_417297 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417297 RefSeq WP_001285993 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001285993 SMR P08394 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P08394 STRING 511145.b2820 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2820&targetmode=cogs STRING COG1074 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1074&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SUPFAM SSF52980 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52980 TIGRFAMs TIGR00609 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00609 UniProtKB RECB_ECOLI http://www.uniprot.org/uniprot/RECB_ECOLI UniProtKB-AC P08394 http://www.uniprot.org/uniprot/P08394 charge swissprot:RECB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RECB_ECOLI eggNOG COG1074 http://eggnogapi.embl.de/nog_data/html/tree/COG1074 eggNOG ENOG4107QKA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QKA epestfind swissprot:RECB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RECB_ECOLI garnier swissprot:RECB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RECB_ECOLI helixturnhelix swissprot:RECB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RECB_ECOLI hmoment swissprot:RECB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RECB_ECOLI iep swissprot:RECB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RECB_ECOLI inforesidue swissprot:RECB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RECB_ECOLI octanol swissprot:RECB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RECB_ECOLI pepcoil swissprot:RECB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RECB_ECOLI pepdigest swissprot:RECB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RECB_ECOLI pepinfo swissprot:RECB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RECB_ECOLI pepnet swissprot:RECB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RECB_ECOLI pepstats swissprot:RECB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RECB_ECOLI pepwheel swissprot:RECB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RECB_ECOLI pepwindow swissprot:RECB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RECB_ECOLI sigcleave swissprot:RECB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RECB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260140 9 # EcoGene EG13905 yciT # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; ISS:EcoCyc. # GO_process GO:0006355 regulation of transcription, DNA-templated; IMP:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # IntAct P76034 6 # InterPro IPR001034 DeoR_HTH # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR014036 DeoR_C # InterPro IPR018356 Tscrpt_reg_HTH_DeoR_CS # Organism YCIT_ECOLI Escherichia coli (strain K12) # PATRIC 32117832 VBIEscCol129921_1336 # PIR G64876 G64876 # PRINTS PR00037 HTHLACR # PROSITE PS00894 HTH_DEOR_1 # PROSITE PS51000 HTH_DEOR_2 # Pfam PF00455 DeoRC # Pfam PF08220 HTH_DeoR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCIT_ECOLI Uncharacterized HTH-type transcriptional regulator YciT # RefSeq NP_415800 NC_000913.3 # RefSeq WP_001088620 NZ_LN832404.1 # SIMILARITY Contains 1 HTH deoR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00349}. # SMART SM00420 HTH_DEOR # SUPFAM SSF46785 SSF46785 # eggNOG COG1349 LUCA # eggNOG ENOG4105N2W Bacteria BLAST swissprot:YCIT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCIT_ECOLI BioCyc ECOL316407:JW1276-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1276-MONOMER BioCyc EcoCyc:G6638-MONOMER http://biocyc.org/getid?id=EcoCyc:G6638-MONOMER DIP DIP-11592N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11592N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3664 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3664 EcoGene EG13905 http://www.ecogene.org/geneInfo.php?eg_id=EG13905 EnsemblBacteria AAC74366 http://www.ensemblgenomes.org/id/AAC74366 EnsemblBacteria AAC74366 http://www.ensemblgenomes.org/id/AAC74366 EnsemblBacteria BAA14838 http://www.ensemblgenomes.org/id/BAA14838 EnsemblBacteria BAA14838 http://www.ensemblgenomes.org/id/BAA14838 EnsemblBacteria BAA14838 http://www.ensemblgenomes.org/id/BAA14838 EnsemblBacteria b1284 http://www.ensemblgenomes.org/id/b1284 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 945869 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945869 HOGENOM HOG000224683 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000224683&db=HOGENOM6 InParanoid P76034 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76034 IntAct P76034 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76034* InterPro IPR001034 http://www.ebi.ac.uk/interpro/entry/IPR001034 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR014036 http://www.ebi.ac.uk/interpro/entry/IPR014036 InterPro IPR018356 http://www.ebi.ac.uk/interpro/entry/IPR018356 KEGG_Gene ecj:JW1276 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1276 KEGG_Gene eco:b1284 http://www.genome.jp/dbget-bin/www_bget?eco:b1284 OMA DARMNIN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DARMNIN PRINTS PR00037 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00037 PROSITE PS00894 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00894 PROSITE PS51000 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51000 PSORT swissprot:YCIT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCIT_ECOLI PSORT-B swissprot:YCIT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCIT_ECOLI PSORT2 swissprot:YCIT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCIT_ECOLI Pfam PF00455 http://pfam.xfam.org/family/PF00455 Pfam PF08220 http://pfam.xfam.org/family/PF08220 Phobius swissprot:YCIT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCIT_ECOLI PhylomeDB P76034 http://phylomedb.org/?seqid=P76034 ProteinModelPortal P76034 http://www.proteinmodelportal.org/query/uniprot/P76034 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415800 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415800 RefSeq WP_001088620 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001088620 SMART SM00420 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00420 STRING 511145.b1284 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1284&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB YCIT_ECOLI http://www.uniprot.org/uniprot/YCIT_ECOLI UniProtKB-AC P76034 http://www.uniprot.org/uniprot/P76034 charge swissprot:YCIT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCIT_ECOLI eggNOG COG1349 http://eggnogapi.embl.de/nog_data/html/tree/COG1349 eggNOG ENOG4105N2W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105N2W epestfind swissprot:YCIT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCIT_ECOLI garnier swissprot:YCIT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCIT_ECOLI helixturnhelix swissprot:YCIT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCIT_ECOLI hmoment swissprot:YCIT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCIT_ECOLI iep swissprot:YCIT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCIT_ECOLI inforesidue swissprot:YCIT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCIT_ECOLI octanol swissprot:YCIT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCIT_ECOLI pepcoil swissprot:YCIT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCIT_ECOLI pepdigest swissprot:YCIT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCIT_ECOLI pepinfo swissprot:YCIT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCIT_ECOLI pepnet swissprot:YCIT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCIT_ECOLI pepstats swissprot:YCIT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCIT_ECOLI pepwheel swissprot:YCIT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCIT_ECOLI pepwindow swissprot:YCIT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCIT_ECOLI sigcleave swissprot:YCIT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCIT_ECOLI ## Database ID URL or Descriptions # AltName H(+)/threonine-serine symporter {ECO:0000255|HAMAP-Rule MF_01583} # BioGrid 4262418 8 # EcoGene EG10991 tdcC # FUNCTION TDCC_ECOLI Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system). {ECO 0000255|HAMAP-Rule MF_01583, ECO 0000269|PubMed 9498571}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoliWiki. # GO_component GO:0016021 integral component of membrane; IDA:EcoliWiki. # GO_function GO:0015194 L-serine transmembrane transporter activity; IMP:EcoCyc. # GO_function GO:0015195 L-threonine transmembrane transporter activity; IMP:EcoCyc. # GO_function GO:0015565 threonine efflux transmembrane transporter activity; IEA:InterPro. # GO_function TDCC_ECOLI GO 0015295 solute proton symporter activity; IDA EcoCyc. # GO_process GO:0006865 amino acid transport; IMP:EcoliWiki. # GO_process GO:0015825 L-serine transport; IMP:EcoCyc. # GO_process GO:0015826 threonine transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # HAMAP MF_01583 Thr_Ser_transp_TdcC # InterPro IPR004694 Hydroxy_aa_transpt # InterPro IPR018227 Tryptophan/tyrosine_permease # InterPro IPR023726 Thr/Ser_transpt_TdcC # KEGG_Brite ko02000 Transporters # Organism TDCC_ECOLI Escherichia coli (strain K12) # PATRIC 32121648 VBIEscCol129921_3210 # PIR A65101 BVECTC # Pfam PF03222 Trp_Tyr_perm # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Threonine/serine transporter TdcC {ECO:0000255|HAMAP-Rule MF_01583} # RefSeq NP_417586 NC_000913.3 # RefSeq WP_000107723 NZ_LN832404.1 # SIMILARITY Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily. {ECO:0000255|HAMAP-Rule MF_01583}. # SUBCELLULAR LOCATION TDCC_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01583, ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255|HAMAP-Rule MF_01583, ECO 0000269|PubMed 15919996}. # TCDB 2.A.42.2 the hydroxy/aromatic amino acid permease (haaap) family # TIGRFAMs TIGR00814 stp # eggNOG COG0814 LUCA # eggNOG ENOG4108MST Bacteria BLAST swissprot:TDCC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TDCC_ECOLI BioCyc ECOL316407:JW3087-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3087-MONOMER BioCyc EcoCyc:TDCC-MONOMER http://biocyc.org/getid?id=EcoCyc:TDCC-MONOMER BioCyc MetaCyc:TDCC-MONOMER http://biocyc.org/getid?id=MetaCyc:TDCC-MONOMER COG COG0814 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0814 DIP DIP-48056N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48056N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/17.10.3994 http://dx.doi.org/10.1093/nar/17.10.3994 DOI 10.1093/oxfordjournals.jbchem.a021887 http://dx.doi.org/10.1093/oxfordjournals.jbchem.a021887 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M23638 http://www.ebi.ac.uk/ena/data/view/M23638 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X14430 http://www.ebi.ac.uk/ena/data/view/X14430 EchoBASE EB0984 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0984 EcoGene EG10991 http://www.ecogene.org/geneInfo.php?eg_id=EG10991 EnsemblBacteria AAC76151 http://www.ensemblgenomes.org/id/AAC76151 EnsemblBacteria AAC76151 http://www.ensemblgenomes.org/id/AAC76151 EnsemblBacteria BAE77165 http://www.ensemblgenomes.org/id/BAE77165 EnsemblBacteria BAE77165 http://www.ensemblgenomes.org/id/BAE77165 EnsemblBacteria BAE77165 http://www.ensemblgenomes.org/id/BAE77165 EnsemblBacteria b3116 http://www.ensemblgenomes.org/id/b3116 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015194 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015194 GO_function GO:0015195 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015195 GO_function GO:0015295 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015295 GO_function GO:0015565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015565 GO_process GO:0006865 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865 GO_process GO:0015825 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015825 GO_process GO:0015826 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015826 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 947629 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947629 HAMAP MF_01583 http://hamap.expasy.org/unirule/MF_01583 HOGENOM HOG000270787 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000270787&db=HOGENOM6 IntAct P0AAD8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAD8* InterPro IPR004694 http://www.ebi.ac.uk/interpro/entry/IPR004694 InterPro IPR018227 http://www.ebi.ac.uk/interpro/entry/IPR018227 InterPro IPR023726 http://www.ebi.ac.uk/interpro/entry/IPR023726 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3087 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3087 KEGG_Gene eco:b3116 http://www.genome.jp/dbget-bin/www_bget?eco:b3116 KEGG_Orthology KO:K03838 http://www.genome.jp/dbget-bin/www_bget?KO:K03838 MINT MINT-1252560 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1252560 OMA ANHFSSM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ANHFSSM PSORT swissprot:TDCC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TDCC_ECOLI PSORT-B swissprot:TDCC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TDCC_ECOLI PSORT2 swissprot:TDCC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TDCC_ECOLI Pfam PF03222 http://pfam.xfam.org/family/PF03222 Phobius swissprot:TDCC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TDCC_ECOLI PhylomeDB P0AAD8 http://phylomedb.org/?seqid=P0AAD8 ProteinModelPortal P0AAD8 http://www.proteinmodelportal.org/query/uniprot/P0AAD8 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2660107 http://www.ncbi.nlm.nih.gov/pubmed/2660107 PubMed 3053659 http://www.ncbi.nlm.nih.gov/pubmed/3053659 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9498571 http://www.ncbi.nlm.nih.gov/pubmed/9498571 RefSeq NP_417586 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417586 RefSeq WP_000107723 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000107723 STRING 511145.b3116 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3116&targetmode=cogs STRING COG0814 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0814&targetmode=cogs TCDB 2.A.42.2 http://www.tcdb.org/search/result.php?tc=2.A.42.2 TIGRFAMs TIGR00814 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00814 UniProtKB TDCC_ECOLI http://www.uniprot.org/uniprot/TDCC_ECOLI UniProtKB-AC P0AAD8 http://www.uniprot.org/uniprot/P0AAD8 charge swissprot:TDCC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TDCC_ECOLI eggNOG COG0814 http://eggnogapi.embl.de/nog_data/html/tree/COG0814 eggNOG ENOG4108MST http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108MST epestfind swissprot:TDCC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TDCC_ECOLI garnier swissprot:TDCC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TDCC_ECOLI helixturnhelix swissprot:TDCC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TDCC_ECOLI hmoment swissprot:TDCC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TDCC_ECOLI iep swissprot:TDCC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TDCC_ECOLI inforesidue swissprot:TDCC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TDCC_ECOLI octanol swissprot:TDCC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TDCC_ECOLI pepcoil swissprot:TDCC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TDCC_ECOLI pepdigest swissprot:TDCC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TDCC_ECOLI pepinfo swissprot:TDCC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TDCC_ECOLI pepnet swissprot:TDCC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TDCC_ECOLI pepstats swissprot:TDCC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TDCC_ECOLI pepwheel swissprot:TDCC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TDCC_ECOLI pepwindow swissprot:TDCC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TDCC_ECOLI sigcleave swissprot:TDCC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TDCC_ECOLI ## Database ID URL or Descriptions # AltName PUTA_ECOLI L-glutamate gamma-semialdehyde dehydrogenase # AltName PUTA_ECOLI Proline oxidase # AltName PUTA_ECOLI Proline oxidase # BRENDA 1.2.1.88 2026 # BRENDA 1.5.5 2026 # BioGrid 4262846 6 # CATALYTIC ACTIVITY PUTA_ECOLI L-glutamate 5-semialdehyde + NAD(+) + H(2)O = L-glutamate + NADH. # CATALYTIC ACTIVITY PUTA_ECOLI L-proline + a quinone = (S)-1-pyrroline-5- carboxylate + a quinol. # COFACTOR Name=FAD; Xref=ChEBI:CHEBI 57692; # DrugBank DB03147 Flavin adenine dinucleotide # DrugBank DB04398 Lactic Acid # EcoGene EG10801 putA # FUNCTION PUTA_ECOLI Oxidizes proline to glutamate for use as a carbon and nitrogen source and also function as a transcriptional repressor of the put operon. # GO_component GO:0009898 cytoplasmic side of plasma membrane; IDA:EcoCyc. # GO_function GO:0000986 bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding; IDA:EcoCyc. # GO_function GO:0001141 transcriptional repressor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0003842 1-pyrroline-5-carboxylate dehydrogenase activity; IDA:EcoCyc. # GO_function GO:0004029 aldehyde dehydrogenase (NAD) activity; IBA:GO_Central. # GO_function GO:0004657 proline dehydrogenase activity; IDA:UniProtKB. # GO_function GO:0043565 sequence-specific DNA binding; IDA:UniProtKB. # GO_function GO:0050660 flavin adenine dinucleotide binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006561 proline biosynthetic process; IEA:InterPro. # GO_process GO:0010133 proline catabolic process to glutamate; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.2060.10 -; 1. # Gene3D 1.20.5.550 -; 1. # Gene3D 3.20.20.220 -; 1. # Gene3D 3.40.309.10 -; 1. # Gene3D 3.40.605.10 -; 1. # INDUCTION PUTA_ECOLI By proline, autorepression and catabolite repression, and is potentially nitrogen controlled. # IntAct P09546 23 # InterPro IPR002872 Proline_DH_dom # InterPro IPR005933 Delta1-pyrroline-5-COlate_DH-3 # InterPro IPR010985 Ribbon_hlx_hlx # InterPro IPR015590 Aldehyde_DH_dom # InterPro IPR016160 Ald_DH_CS_CYS # InterPro IPR016161 Ald_DH/histidinol_DH # InterPro IPR016162 Ald_DH_N # InterPro IPR016163 Ald_DH_C # InterPro IPR024082 PRODH_PutA_dom_II # InterPro IPR024089 PRODH_PutA_dom_I/II # InterPro IPR024090 PRODH_PutA_dom_I # InterPro IPR025703 Bifunct_PutA # InterPro IPR029041 FAD-linked_oxidoreductase-like # InterPro IPR029510 Ald_DH_CS_GLU # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00250 Alanine, aspartate and glutamate metabolism # KEGG_Pathway ko00330 Arginine and proline metabolism # Organism PUTA_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid degradation; L-proline degradation into L- glutamate; L-glutamate from L-proline step 1/2. # PATHWAY Amino-acid degradation; L-proline degradation into L- glutamate; L-glutamate from L-proline step 2/2. # PATRIC 32117257 VBIEscCol129921_1052 # PDB 1TIW X-ray; 2.00 A; A=86-669 # PDB 1TJ0 X-ray; 2.10 A; A=86-669 # PDB 1TJ1 X-ray; 2.00 A; A=86-669 # PDB 1TJ2 X-ray; 2.05 A; A=86-669 # PDB 2AY0 X-ray; 2.10 A; A/B/C/D/E/F=1-52 # PDB 2FZM X-ray; 2.30 A; A=86-669 # PDB 2FZN X-ray; 2.00 A; A=86-669 # PDB 2GPE X-ray; 1.90 A; A/B/C/D=1-52 # PDB 2RBF X-ray; 2.25 A; A/B=1-52 # PDB 3E2Q X-ray; 1.75 A; A=86-630 # PDB 3E2R X-ray; 1.85 A; A=86-630 # PDB 3E2S X-ray; 2.00 A; A=86-630 # PDB 3ITG X-ray; 2.15 A; A/B=86-669 # PDB 4JNY X-ray; 1.90 A; A=86-669 # PDB 4JNZ X-ray; 1.85 A; A=86-669 # PDB 4O8A X-ray; 2.00 A; A=1-669 # PIR D64843 D64843 # PIRSF PIRSF000197 Bifunct_PutA # PROSITE PS00070 ALDEHYDE_DEHYDR_CYS # PROSITE PS00687 ALDEHYDE_DEHYDR_GLU # Pfam PF00171 Aldedh # Pfam PF01619 Pro_dh # Pfam PF14850 Pro_dh-DNA_bdg # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PUTA_ECOLI Bifunctional protein PutA # RecName PUTA_ECOLI Bifunctional protein PutA # RecName PUTA_ECOLI Delta-1-pyrroline-5-carboxylate dehydrogenase # RecName PUTA_ECOLI Proline dehydrogenase # RefSeq NP_415534 NC_000913.3 # RefSeq WP_001326840 NZ_LN832404.1 # SIMILARITY In the C-terminal section; belongs to the aldehyde dehydrogenase family. {ECO 0000305}. # SIMILARITY In the N-terminal section; belongs to the proline dehydrogenase family. {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 12514740}. # SUPFAM SSF47598 SSF47598 # SUPFAM SSF51730 SSF51730 # SUPFAM SSF53720 SSF53720 # SUPFAM SSF81935 SSF81935 # TIGRFAMs TIGR01238 D1pyr5carbox3 # UniPathway UPA00261 UER00373 # UniPathway UPA00261 UER00374 # eggNOG COG0506 LUCA # eggNOG COG4230 LUCA # eggNOG ENOG4105C26 Bacteria BLAST swissprot:PUTA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PUTA_ECOLI BioCyc ECOL316407:JW0999-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0999-MONOMER BioCyc EcoCyc:PUTA-MONOMER http://biocyc.org/getid?id=EcoCyc:PUTA-MONOMER BioCyc MetaCyc:PUTA-MONOMER http://biocyc.org/getid?id=MetaCyc:PUTA-MONOMER COG COG0506 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0506 COG COG1012 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1012 COG COG4230 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4230 DIP DIP-10620N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10620N DOI 10.1006/jmbi.1994.1696 http://dx.doi.org/10.1006/jmbi.1994.1696 DOI 10.1007/BF00325707 http://dx.doi.org/10.1007/BF00325707 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsb885 http://dx.doi.org/10.1038/nsb885 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB03147 http://www.drugbank.ca/drugs/DB03147 DrugBank DB04398 http://www.drugbank.ca/drugs/DB04398 EC_number EC:1.2.1.88 http://www.genome.jp/dbget-bin/www_bget?EC:1.2.1.88 EC_number EC:1.5.5.2 http://www.genome.jp/dbget-bin/www_bget?EC:1.5.5.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U05212 http://www.ebi.ac.uk/ena/data/view/U05212 EMBL X05653 http://www.ebi.ac.uk/ena/data/view/X05653 ENZYME 1.2.1.88 http://enzyme.expasy.org/EC/1.2.1.88 ENZYME 1.5.5.2 http://enzyme.expasy.org/EC/1.5.5.2 EchoBASE EB0794 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0794 EcoGene EG10801 http://www.ecogene.org/geneInfo.php?eg_id=EG10801 EnsemblBacteria AAC74099 http://www.ensemblgenomes.org/id/AAC74099 EnsemblBacteria AAC74099 http://www.ensemblgenomes.org/id/AAC74099 EnsemblBacteria BAA35791 http://www.ensemblgenomes.org/id/BAA35791 EnsemblBacteria BAA35791 http://www.ensemblgenomes.org/id/BAA35791 EnsemblBacteria BAA35791 http://www.ensemblgenomes.org/id/BAA35791 EnsemblBacteria b1014 http://www.ensemblgenomes.org/id/b1014 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009898 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009898 GO_function GO:0000986 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000986 GO_function GO:0001141 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001141 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003842 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003842 GO_function GO:0004029 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004029 GO_function GO:0004657 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004657 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006561 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006561 GO_process GO:0010133 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010133 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.2060.10 http://www.cathdb.info/version/latest/superfamily/1.10.2060.10 Gene3D 1.20.5.550 http://www.cathdb.info/version/latest/superfamily/1.20.5.550 Gene3D 3.20.20.220 http://www.cathdb.info/version/latest/superfamily/3.20.20.220 Gene3D 3.40.309.10 http://www.cathdb.info/version/latest/superfamily/3.40.309.10 Gene3D 3.40.605.10 http://www.cathdb.info/version/latest/superfamily/3.40.605.10 GeneID 945600 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945600 HOGENOM HOG000253911 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000253911&db=HOGENOM6 InParanoid P09546 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P09546 IntAct P09546 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P09546* IntEnz 1.2.1.88 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.2.1.88 IntEnz 1.5.5.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.5.5.2 InterPro IPR002872 http://www.ebi.ac.uk/interpro/entry/IPR002872 InterPro IPR005933 http://www.ebi.ac.uk/interpro/entry/IPR005933 InterPro IPR010985 http://www.ebi.ac.uk/interpro/entry/IPR010985 InterPro IPR015590 http://www.ebi.ac.uk/interpro/entry/IPR015590 InterPro IPR016160 http://www.ebi.ac.uk/interpro/entry/IPR016160 InterPro IPR016161 http://www.ebi.ac.uk/interpro/entry/IPR016161 InterPro IPR016162 http://www.ebi.ac.uk/interpro/entry/IPR016162 InterPro IPR016163 http://www.ebi.ac.uk/interpro/entry/IPR016163 InterPro IPR024082 http://www.ebi.ac.uk/interpro/entry/IPR024082 InterPro IPR024089 http://www.ebi.ac.uk/interpro/entry/IPR024089 InterPro IPR024090 http://www.ebi.ac.uk/interpro/entry/IPR024090 InterPro IPR025703 http://www.ebi.ac.uk/interpro/entry/IPR025703 InterPro IPR029041 http://www.ebi.ac.uk/interpro/entry/IPR029041 InterPro IPR029510 http://www.ebi.ac.uk/interpro/entry/IPR029510 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0999 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0999 KEGG_Gene eco:b1014 http://www.genome.jp/dbget-bin/www_bget?eco:b1014 KEGG_Orthology KO:K13821 http://www.genome.jp/dbget-bin/www_bget?KO:K13821 KEGG_Pathway ko00250 http://www.genome.jp/kegg-bin/show_pathway?ko00250 KEGG_Pathway ko00330 http://www.genome.jp/kegg-bin/show_pathway?ko00330 KEGG_Reaction rn:R00245 http://www.genome.jp/dbget-bin/www_bget?rn:R00245 KEGG_Reaction rn:R00707 http://www.genome.jp/dbget-bin/www_bget?rn:R00707 KEGG_Reaction rn:R00708 http://www.genome.jp/dbget-bin/www_bget?rn:R00708 KEGG_Reaction rn:R01253 http://www.genome.jp/dbget-bin/www_bget?rn:R01253 KEGG_Reaction rn:R04444 http://www.genome.jp/dbget-bin/www_bget?rn:R04444 KEGG_Reaction rn:R04445 http://www.genome.jp/dbget-bin/www_bget?rn:R04445 KEGG_Reaction rn:R05051 http://www.genome.jp/dbget-bin/www_bget?rn:R05051 MINT MINT-1267731 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1267731 OMA YSLDTQE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YSLDTQE PDB 1TIW http://www.ebi.ac.uk/pdbe-srv/view/entry/1TIW PDB 1TJ0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1TJ0 PDB 1TJ1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1TJ1 PDB 1TJ2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1TJ2 PDB 2AY0 http://www.ebi.ac.uk/pdbe-srv/view/entry/2AY0 PDB 2FZM http://www.ebi.ac.uk/pdbe-srv/view/entry/2FZM PDB 2FZN http://www.ebi.ac.uk/pdbe-srv/view/entry/2FZN PDB 2GPE http://www.ebi.ac.uk/pdbe-srv/view/entry/2GPE PDB 2RBF http://www.ebi.ac.uk/pdbe-srv/view/entry/2RBF PDB 3E2Q http://www.ebi.ac.uk/pdbe-srv/view/entry/3E2Q PDB 3E2R http://www.ebi.ac.uk/pdbe-srv/view/entry/3E2R PDB 3E2S http://www.ebi.ac.uk/pdbe-srv/view/entry/3E2S PDB 3ITG http://www.ebi.ac.uk/pdbe-srv/view/entry/3ITG PDB 4JNY http://www.ebi.ac.uk/pdbe-srv/view/entry/4JNY PDB 4JNZ http://www.ebi.ac.uk/pdbe-srv/view/entry/4JNZ PDB 4O8A http://www.ebi.ac.uk/pdbe-srv/view/entry/4O8A PDBsum 1TIW http://www.ebi.ac.uk/pdbsum/1TIW PDBsum 1TJ0 http://www.ebi.ac.uk/pdbsum/1TJ0 PDBsum 1TJ1 http://www.ebi.ac.uk/pdbsum/1TJ1 PDBsum 1TJ2 http://www.ebi.ac.uk/pdbsum/1TJ2 PDBsum 2AY0 http://www.ebi.ac.uk/pdbsum/2AY0 PDBsum 2FZM http://www.ebi.ac.uk/pdbsum/2FZM PDBsum 2FZN http://www.ebi.ac.uk/pdbsum/2FZN PDBsum 2GPE http://www.ebi.ac.uk/pdbsum/2GPE PDBsum 2RBF http://www.ebi.ac.uk/pdbsum/2RBF PDBsum 3E2Q http://www.ebi.ac.uk/pdbsum/3E2Q PDBsum 3E2R http://www.ebi.ac.uk/pdbsum/3E2R PDBsum 3E2S http://www.ebi.ac.uk/pdbsum/3E2S PDBsum 3ITG http://www.ebi.ac.uk/pdbsum/3ITG PDBsum 4JNY http://www.ebi.ac.uk/pdbsum/4JNY PDBsum 4JNZ http://www.ebi.ac.uk/pdbsum/4JNZ PDBsum 4O8A http://www.ebi.ac.uk/pdbsum/4O8A PROSITE PS00070 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00070 PROSITE PS00687 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00687 PSORT swissprot:PUTA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PUTA_ECOLI PSORT-B swissprot:PUTA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PUTA_ECOLI PSORT2 swissprot:PUTA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PUTA_ECOLI Pfam PF00171 http://pfam.xfam.org/family/PF00171 Pfam PF01619 http://pfam.xfam.org/family/PF01619 Pfam PF14850 http://pfam.xfam.org/family/PF14850 Phobius swissprot:PUTA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PUTA_ECOLI PhylomeDB P09546 http://phylomedb.org/?seqid=P09546 ProteinModelPortal P09546 http://www.proteinmodelportal.org/query/uniprot/P09546 PubMed 12514740 http://www.ncbi.nlm.nih.gov/pubmed/12514740 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3325781 http://www.ncbi.nlm.nih.gov/pubmed/3325781 PubMed 7966312 http://www.ncbi.nlm.nih.gov/pubmed/7966312 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415534 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415534 RefSeq WP_001326840 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001326840 SMR P09546 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P09546 STRING 511145.b1014 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1014&targetmode=cogs STRING COG0506 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0506&targetmode=cogs STRING COG1012 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1012&targetmode=cogs STRING COG4230 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4230&targetmode=cogs SUPFAM SSF47598 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47598 SUPFAM SSF51730 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51730 SUPFAM SSF53720 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53720 SUPFAM SSF81935 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81935 TIGRFAMs TIGR01238 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01238 UniProtKB PUTA_ECOLI http://www.uniprot.org/uniprot/PUTA_ECOLI UniProtKB-AC P09546 http://www.uniprot.org/uniprot/P09546 charge swissprot:PUTA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PUTA_ECOLI eggNOG COG0506 http://eggnogapi.embl.de/nog_data/html/tree/COG0506 eggNOG COG4230 http://eggnogapi.embl.de/nog_data/html/tree/COG4230 eggNOG ENOG4105C26 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C26 epestfind swissprot:PUTA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PUTA_ECOLI garnier swissprot:PUTA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PUTA_ECOLI helixturnhelix swissprot:PUTA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PUTA_ECOLI hmoment swissprot:PUTA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PUTA_ECOLI iep swissprot:PUTA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PUTA_ECOLI inforesidue swissprot:PUTA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PUTA_ECOLI octanol swissprot:PUTA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PUTA_ECOLI pepcoil swissprot:PUTA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PUTA_ECOLI pepdigest swissprot:PUTA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PUTA_ECOLI pepinfo swissprot:PUTA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PUTA_ECOLI pepnet swissprot:PUTA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PUTA_ECOLI pepstats swissprot:PUTA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PUTA_ECOLI pepwheel swissprot:PUTA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PUTA_ECOLI pepwindow swissprot:PUTA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PUTA_ECOLI sigcleave swissprot:PUTA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PUTA_ECOLI ## Database ID URL or Descriptions # EcoGene EG14450 ymgJ # Organism YMGJ_ECOLI Escherichia coli (strain K12) # Proteomes UP000000625 Chromosome # RecName YMGJ_ECOLI Uncharacterized protein YmgJ # RefSeq YP_001165315 NC_000913.3 BLAST swissprot:YMGJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YMGJ_ECOLI BioCyc EcoCyc:MONOMER0-2819 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2819 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14450 http://www.ecogene.org/geneInfo.php?eg_id=EG14450 EnsemblBacteria ABP93441 http://www.ensemblgenomes.org/id/ABP93441 EnsemblBacteria ABP93441 http://www.ensemblgenomes.org/id/ABP93441 EnsemblBacteria b4594 http://www.ensemblgenomes.org/id/b4594 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 5061516 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5061516 HOGENOM HOG000054850 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000054850&db=HOGENOM6 KEGG_Gene eco:b4594 http://www.genome.jp/dbget-bin/www_bget?eco:b4594 OMA SVRQYYL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SVRQYYL PSORT swissprot:YMGJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YMGJ_ECOLI PSORT-B swissprot:YMGJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YMGJ_ECOLI PSORT2 swissprot:YMGJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YMGJ_ECOLI Phobius swissprot:YMGJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YMGJ_ECOLI ProteinModelPortal A5A612 http://www.proteinmodelportal.org/query/uniprot/A5A612 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq YP_001165315 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001165315 STRING 511145.b4594 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4594&targetmode=cogs UniProtKB YMGJ_ECOLI http://www.uniprot.org/uniprot/YMGJ_ECOLI UniProtKB-AC A5A612 http://www.uniprot.org/uniprot/A5A612 charge swissprot:YMGJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YMGJ_ECOLI epestfind swissprot:YMGJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YMGJ_ECOLI garnier swissprot:YMGJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YMGJ_ECOLI helixturnhelix swissprot:YMGJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YMGJ_ECOLI hmoment swissprot:YMGJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YMGJ_ECOLI iep swissprot:YMGJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YMGJ_ECOLI inforesidue swissprot:YMGJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YMGJ_ECOLI octanol swissprot:YMGJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YMGJ_ECOLI pepcoil swissprot:YMGJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YMGJ_ECOLI pepdigest swissprot:YMGJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YMGJ_ECOLI pepinfo swissprot:YMGJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YMGJ_ECOLI pepnet swissprot:YMGJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YMGJ_ECOLI pepstats swissprot:YMGJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YMGJ_ECOLI pepwheel swissprot:YMGJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YMGJ_ECOLI pepwindow swissprot:YMGJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YMGJ_ECOLI sigcleave swissprot:YMGJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YMGJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4259755 20 # EcoGene EG11621 metN # FUNCTION METN_ECOLI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (Probable). It has also been shown to be involved in formyl-L-methionine transport. {ECO 0000255|HAMAP- Rule MF_01719, ECO 0000269|PubMed 12169620, ECO 0000269|PubMed 12819857, ECO 0000305}. # GO_component GO:0009276 Gram-negative-bacterium-type cell wall; IEA:InterPro. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IEA:UniProtKB-HAMAP. # GO_function GO:0005524 ATP binding; IDA:EcoliWiki. # GO_function GO:0015424 amino acid-transporting ATPase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0016887 ATPase activity; IDA:EcoliWiki. # GO_function GO:0048474 D-methionine transmembrane transporter activity; IDA:EcoliWiki. # GO_process GO:0048473 D-methionine transport; IMP:CACAO. # GOslim_component GO:0005618 cell wall # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # Gene3D 3.40.50.300 -; 1. # INTERACTION METN_ECOLI P16433 hycG; NbExp=5; IntAct=EBI-541886, EBI-541977; P31547 metI; NbExp=2; IntAct=EBI-541886, EBI-8769561; P0A9F1 mntR; NbExp=3; IntAct=EBI-541886, EBI-541895; # IntAct P30750 55 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR012692 ABC_MetN_proteobac # InterPro IPR017871 ABC_transporter_CS # InterPro IPR017908 ABC_transprt_methionine_MetN_C # InterPro IPR018449 NIL_domain # InterPro IPR026253 ABC_MetN # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00238 D-Methionine transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism METN_ECOLI Escherichia coli (strain K12) # PANTHER PTHR24220:SF455 PTHR24220:SF455 # PATRIC 32115511 VBIEscCol129921_0207 # PDB 3DHW X-ray; 3.70 A; C/D/G/H=1-343 # PDB 3DHX X-ray; 2.10 A; A/B=246-343 # PDB 3TUI X-ray; 2.90 A; C/D/G/H=1-343 # PDB 3TUJ X-ray; 4.00 A; C/D=1-343 # PDB 3TUZ X-ray; 3.40 A; C/D/G/H=1-343 # PIR G64744 G64744 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # PROSITE PS51264 METN # Pfam PF00005 ABC_tran # Pfam PF09383 NIL # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Methionine import ATP-binding protein MetN {ECO:0000255|HAMAP-Rule MF_01719} # RefSeq NP_414741 NC_000913.3 # RefSeq WP_000594006 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAC36869.1; Type=Frameshift; Positions=200; Evidence={ECO:0000305}; Sequence=BAA03659.1; Type=Frameshift; Positions=106, 156; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family. {ECO:0000255|HAMAP-Rule MF_01719}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|HAMAP- Rule MF_01719}. # SMART SM00382 AAA # SMART SM00930 NIL # SUBCELLULAR LOCATION METN_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01719}; Peripheral membrane protein {ECO 0000255|HAMAP- Rule MF_01719}. # SUBUNIT The complex is composed of two ATP-binding proteins (MetN), two transmembrane proteins (MetI) and a solute-binding protein (MetQ). {ECO:0000255|HAMAP-Rule MF_01719}. # SUPFAM SSF52540 SSF52540 # TCDB 3.A.1.24 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR02314 ABC_MetN # eggNOG COG1135 LUCA # eggNOG ENOG4108JEI Bacteria BLAST swissprot:METN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:METN_ECOLI BioCyc ECOL316407:JW0195-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0195-MONOMER BioCyc EcoCyc:ABC-MONOMER http://biocyc.org/getid?id=EcoCyc:ABC-MONOMER BioCyc MetaCyc:ABC-MONOMER http://biocyc.org/getid?id=MetaCyc:ABC-MONOMER COG COG1135 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1135 DIP DIP-9027N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9027N DOI 10.1007/s00203-003-0561-4 http://dx.doi.org/10.1007/s00203-003-0561-4 DOI 10.1016/0378-1119(93)90470-N http://dx.doi.org/10.1016/0378-1119(93)90470-N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.17.4930-4932.2002 http://dx.doi.org/10.1128/JB.184.17.4930-4932.2002 EC_number EC:3.6.3.- {ECO:0000255|HAMAP-Rule:MF_01719} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.- {ECO:0000255|HAMAP-Rule:MF_01719} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D15061 http://www.ebi.ac.uk/ena/data/view/D15061 EMBL L08626 http://www.ebi.ac.uk/ena/data/view/L08626 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 ENZYME 3.6.3.- {ECO:0000255|HAMAP-Rule:MF_01719} http://enzyme.expasy.org/EC/3.6.3.- {ECO:0000255|HAMAP-Rule:MF_01719} EchoBASE EB1578 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1578 EcoGene EG11621 http://www.ecogene.org/geneInfo.php?eg_id=EG11621 EnsemblBacteria AAC73310 http://www.ensemblgenomes.org/id/AAC73310 EnsemblBacteria AAC73310 http://www.ensemblgenomes.org/id/AAC73310 EnsemblBacteria BAA77876 http://www.ensemblgenomes.org/id/BAA77876 EnsemblBacteria BAA77876 http://www.ensemblgenomes.org/id/BAA77876 EnsemblBacteria BAA77876 http://www.ensemblgenomes.org/id/BAA77876 EnsemblBacteria b0199 http://www.ensemblgenomes.org/id/b0199 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009276 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0015424 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015424 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_function GO:0048474 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048474 GO_process GO:0048473 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048473 GOslim_component GO:0005618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005618 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 944896 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944896 InParanoid P30750 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P30750 IntAct P30750 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P30750* IntEnz 3.6.3.- {ECO:0000255|HAMAP-Rule:MF_01719} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.- {ECO:0000255|HAMAP-Rule:MF_01719} InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR012692 http://www.ebi.ac.uk/interpro/entry/IPR012692 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR017908 http://www.ebi.ac.uk/interpro/entry/IPR017908 InterPro IPR018449 http://www.ebi.ac.uk/interpro/entry/IPR018449 InterPro IPR026253 http://www.ebi.ac.uk/interpro/entry/IPR026253 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0195 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0195 KEGG_Gene eco:b0199 http://www.genome.jp/dbget-bin/www_bget?eco:b0199 KEGG_Orthology KO:K02071 http://www.genome.jp/dbget-bin/www_bget?KO:K02071 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 MINT MINT-1223626 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1223626 OMA HDAYPAN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HDAYPAN PANTHER PTHR24220:SF455 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24220:SF455 PDB 3DHW http://www.ebi.ac.uk/pdbe-srv/view/entry/3DHW PDB 3DHX http://www.ebi.ac.uk/pdbe-srv/view/entry/3DHX PDB 3TUI http://www.ebi.ac.uk/pdbe-srv/view/entry/3TUI PDB 3TUJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3TUJ PDB 3TUZ http://www.ebi.ac.uk/pdbe-srv/view/entry/3TUZ PDBsum 3DHW http://www.ebi.ac.uk/pdbsum/3DHW PDBsum 3DHX http://www.ebi.ac.uk/pdbsum/3DHX PDBsum 3TUI http://www.ebi.ac.uk/pdbsum/3TUI PDBsum 3TUJ http://www.ebi.ac.uk/pdbsum/3TUJ PDBsum 3TUZ http://www.ebi.ac.uk/pdbsum/3TUZ PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PROSITE PS51264 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51264 PSORT swissprot:METN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:METN_ECOLI PSORT-B swissprot:METN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:METN_ECOLI PSORT2 swissprot:METN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:METN_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Pfam PF09383 http://pfam.xfam.org/family/PF09383 Phobius swissprot:METN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:METN_ECOLI PhylomeDB P30750 http://phylomedb.org/?seqid=P30750 ProteinModelPortal P30750 http://www.proteinmodelportal.org/query/uniprot/P30750 PubMed 12169620 http://www.ncbi.nlm.nih.gov/pubmed/12169620 PubMed 12819857 http://www.ncbi.nlm.nih.gov/pubmed/12819857 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7904973 http://www.ncbi.nlm.nih.gov/pubmed/7904973 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414741 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414741 RefSeq WP_000594006 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000594006 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMART SM00930 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00930 SMR P30750 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P30750 STRING 511145.b0199 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0199&targetmode=cogs STRING COG1135 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1135&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.24 http://www.tcdb.org/search/result.php?tc=3.A.1.24 TIGRFAMs TIGR02314 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02314 UniProtKB METN_ECOLI http://www.uniprot.org/uniprot/METN_ECOLI UniProtKB-AC P30750 http://www.uniprot.org/uniprot/P30750 charge swissprot:METN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:METN_ECOLI eggNOG COG1135 http://eggnogapi.embl.de/nog_data/html/tree/COG1135 eggNOG ENOG4108JEI http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108JEI epestfind swissprot:METN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:METN_ECOLI garnier swissprot:METN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:METN_ECOLI helixturnhelix swissprot:METN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:METN_ECOLI hmoment swissprot:METN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:METN_ECOLI iep swissprot:METN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:METN_ECOLI inforesidue swissprot:METN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:METN_ECOLI octanol swissprot:METN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:METN_ECOLI pepcoil swissprot:METN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:METN_ECOLI pepdigest swissprot:METN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:METN_ECOLI pepinfo swissprot:METN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:METN_ECOLI pepnet swissprot:METN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:METN_ECOLI pepstats swissprot:METN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:METN_ECOLI pepwheel swissprot:METN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:METN_ECOLI pepwindow swissprot:METN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:METN_ECOLI sigcleave swissprot:METN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:METN_ECOLI ## Database ID URL or Descriptions # AltName NCPP_ECOLI Inosine triphosphatase # AltName NCPP_ECOLI Non-standard purine NTP phosphatase # AltName NCPP_ECOLI Nucleoside-triphosphate phosphatase # AltName NCPP_ECOLI Xanthosine triphosphatase # BIOPHYSICOCHEMICAL PROPERTIES NCPP_ECOLI Kinetic parameters KM=0.5 mM for ITP {ECO 0000269|PubMed 16216582}; KM=0.58 mM for GDP {ECO 0000269|PubMed 16216582}; KM=0.91 mM for magnesium ions {ECO 0000269|PubMed 16216582}; KM=1.17 mM for XTP {ECO 0000269|PubMed 16216582}; KM=1.24 mM for GTP {ECO 0000269|PubMed 16216582}; KM=1.39 mM for manganese ions {ECO 0000269|PubMed 16216582}; KM=2.44 mM for zinc ions {ECO 0000269|PubMed 16216582}; KM=4.51 mM for dITP {ECO 0000269|PubMed 16216582}; Vmax=67 umol/min/mg enzyme with GTP as substrate {ECO 0000269|PubMed 16216582}; Vmax=358 umol/min/mg enzyme with GDP as substrate {ECO 0000269|PubMed 16216582}; Vmax=439 umol/min/mg enzyme with ITP as substrate and zinc ions as cofactor (ar 15 degrees Celsius and at pH 6.75) {ECO 0000269|PubMed 16216582}; Vmax=571 umol/min/mg enzyme with ITP as substrate and manganese ions as cofactor (ar 15 degrees Celsius and at pH 6.75) {ECO 0000269|PubMed 16216582}; Vmax=1264 umol/min/mg enzyme with ITP as substrate and magnesium ions as cofactor (ar 15 degrees Celsius and at pH 6.75) {ECO 0000269|PubMed 16216582}; Vmax=1720 umol/min/mg enzyme with ITP as substrate {ECO 0000269|PubMed 16216582}; Vmax=1849 umol/min/mg enzyme with dITP as substrate {ECO 0000269|PubMed 16216582}; Vmax=7876 umol/min/mg enzyme with XTP as substrate {ECO 0000269|PubMed 16216582}; pH dependence Optimum pH is 6.75. {ECO 0000269|PubMed 16216582}; # BioGrid 4262781 5 # CATALYTIC ACTIVITY NCPP_ECOLI A nucleoside triphosphate + H(2)O = a nucleoside diphosphate + monophosphate. # CAUTION PubMed:7841459 sequence was originally thought to originate from S.typhimurium, but seems to come from an unknown E.coli strain. {ECO 0000305}. # COFACTOR NCPP_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 16216582}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 16216582}; Note=Binds 1 divalent cation per subunit. Activity is maximal in the presence of Mg(2+), while Mn(2+) decreases the activity by 20%. {ECO 0000269|PubMed 16216582}; # ENZYME REGULATION NCPP_ECOLI Competitively inhibited by ATP, GTP and TTP. # EcoGene EG12600 yjjX # FUNCTION NCPP_ECOLI Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions. ITP is the best substrate, followed by XTP, GDP or dITP. Also implicated in the resistance against the thiamine metabolism inhibitors bacimethrin and CF3-HMP. {ECO 0000269|PubMed 16216582}. # GO_function GO:0000166 nucleotide binding; IEA:UniProtKB-KW. # GO_function GO:0017111 nucleoside-triphosphatase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006772 thiamine metabolic process; EXP:EcoliWiki. # GO_process GO:0009117 nucleotide metabolic process; IEA:UniProtKB-KW. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.90.950.10 -; 1. # HAMAP MF_00648 Non_canon_purine_NTPase_YjjX # InterPro IPR002786 Non_canon_purine_NTPase # InterPro IPR026533 NTPase/PRRC1 # InterPro IPR029001 ITPase-like_fam # Organism NCPP_ECOLI Escherichia coli (strain K12) # PATRIC 32124406 VBIEscCol129921_4543 # PDB 1U5W X-ray; 2.30 A; A/B/C/D/E/F/G/H=1-170 # PIR S56618 S56618 # Pfam PF01931 NTPase_I-T # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NCPP_ECOLI Non-canonical purine NTP phosphatase # RefSeq NP_418811 NC_000913.3 # RefSeq WP_001338221 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97290.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the YjjX NTPase family. {ECO 0000305}. # SUBUNIT Homodimer. {ECO:0000269|PubMed 16216582}. # SUPFAM SSF52972 SSF52972 # TIGRFAMs TIGR00258 TIGR00258 # eggNOG COG1986 LUCA # eggNOG ENOG4108K16 Bacteria BLAST swissprot:NCPP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NCPP_ECOLI BioCyc ECOL316407:JW5801-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5801-MONOMER BioCyc EcoCyc:EG12600-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12600-MONOMER BioCyc MetaCyc:EG12600-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12600-MONOMER DIP DIP-12663N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12663N DOI 10.1016/j.str.2005.07.007 http://dx.doi.org/10.1016/j.str.2005.07.007 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M404284200 http://dx.doi.org/10.1074/jbc.M404284200 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1093/nar/8.7.1551 http://dx.doi.org/10.1093/nar/8.7.1551 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.1.- http://www.genome.jp/dbget-bin/www_bget?EC:3.6.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01715 http://www.ebi.ac.uk/ena/data/view/J01715 EMBL L13768 http://www.ebi.ac.uk/ena/data/view/L13768 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 3.6.1.- http://enzyme.expasy.org/EC/3.6.1.- EchoBASE EB2485 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2485 EcoGene EG12600 http://www.ecogene.org/geneInfo.php?eg_id=EG12600 EnsemblBacteria AAC77347 http://www.ensemblgenomes.org/id/AAC77347 EnsemblBacteria AAC77347 http://www.ensemblgenomes.org/id/AAC77347 EnsemblBacteria BAE78383 http://www.ensemblgenomes.org/id/BAE78383 EnsemblBacteria BAE78383 http://www.ensemblgenomes.org/id/BAE78383 EnsemblBacteria BAE78383 http://www.ensemblgenomes.org/id/BAE78383 EnsemblBacteria b4394 http://www.ensemblgenomes.org/id/b4394 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000166 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000166 GO_function GO:0017111 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017111 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006772 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006772 GO_process GO:0009117 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009117 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.90.950.10 http://www.cathdb.info/version/latest/superfamily/3.90.950.10 GeneID 948919 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948919 HAMAP MF_00648 http://hamap.expasy.org/unirule/MF_00648 HOGENOM HOG000098033 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000098033&db=HOGENOM6 InParanoid P39411 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39411 IntEnz 3.6.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.1 InterPro IPR002786 http://www.ebi.ac.uk/interpro/entry/IPR002786 InterPro IPR026533 http://www.ebi.ac.uk/interpro/entry/IPR026533 InterPro IPR029001 http://www.ebi.ac.uk/interpro/entry/IPR029001 KEGG_Gene ecj:JW5801 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5801 KEGG_Gene eco:b4394 http://www.genome.jp/dbget-bin/www_bget?eco:b4394 OMA ADQPMTE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ADQPMTE PDB 1U5W http://www.ebi.ac.uk/pdbe-srv/view/entry/1U5W PDBsum 1U5W http://www.ebi.ac.uk/pdbsum/1U5W PSORT swissprot:NCPP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NCPP_ECOLI PSORT-B swissprot:NCPP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NCPP_ECOLI PSORT2 swissprot:NCPP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NCPP_ECOLI Pfam PF01931 http://pfam.xfam.org/family/PF01931 Phobius swissprot:NCPP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NCPP_ECOLI PhylomeDB P39411 http://phylomedb.org/?seqid=P39411 ProteinModelPortal P39411 http://www.proteinmodelportal.org/query/uniprot/P39411 PubMed 15292217 http://www.ncbi.nlm.nih.gov/pubmed/15292217 PubMed 16216582 http://www.ncbi.nlm.nih.gov/pubmed/16216582 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7001368 http://www.ncbi.nlm.nih.gov/pubmed/7001368 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 7841459 http://www.ncbi.nlm.nih.gov/pubmed/7841459 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418811 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418811 RefSeq WP_001338221 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001338221 SMR P39411 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39411 STRING 511145.b4394 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4394&targetmode=cogs SUPFAM SSF52972 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52972 TIGRFAMs TIGR00258 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00258 UniProtKB NCPP_ECOLI http://www.uniprot.org/uniprot/NCPP_ECOLI UniProtKB-AC P39411 http://www.uniprot.org/uniprot/P39411 charge swissprot:NCPP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NCPP_ECOLI eggNOG COG1986 http://eggnogapi.embl.de/nog_data/html/tree/COG1986 eggNOG ENOG4108K16 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108K16 epestfind swissprot:NCPP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NCPP_ECOLI garnier swissprot:NCPP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NCPP_ECOLI helixturnhelix swissprot:NCPP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NCPP_ECOLI hmoment swissprot:NCPP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NCPP_ECOLI iep swissprot:NCPP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NCPP_ECOLI inforesidue swissprot:NCPP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NCPP_ECOLI octanol swissprot:NCPP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NCPP_ECOLI pepcoil swissprot:NCPP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NCPP_ECOLI pepdigest swissprot:NCPP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NCPP_ECOLI pepinfo swissprot:NCPP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NCPP_ECOLI pepnet swissprot:NCPP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NCPP_ECOLI pepstats swissprot:NCPP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NCPP_ECOLI pepwheel swissprot:NCPP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NCPP_ECOLI pepwindow swissprot:NCPP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NCPP_ECOLI sigcleave swissprot:NCPP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NCPP_ECOLI ## Database ID URL or Descriptions # BioGrid 4261579 3 # EcoGene EG12802 yrbG # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoliWiki. # GO_function GO:0005262 calcium channel activity; IBA:GO_Central. # GO_function GO:0005509 calcium ion binding; IBA:GO_Central. # GO_function GO:0030955 potassium ion binding; IBA:GO_Central. # GO_function GO:0031402 sodium ion binding; IBA:GO_Central. # GO_function YRBG_ECOLI GO 0008273 calcium, potassium sodium antiporter activity; IBA GO_Central. # GO_process GO:0006874 cellular calcium ion homeostasis; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0042592 homeostatic process # InterPro IPR004481 K/Na/Ca-exchanger # InterPro IPR004837 NaCa_Exmemb # KEGG_Brite ko02000 Transporters # Organism YRBG_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10846 PTHR10846 # PATRIC 32121812 VBIEscCol129921_3290 # PIR F65110 F65110 # Pfam PF01699 Na_Ca_ex; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YRBG_ECOLI Inner membrane protein YrbG # RefSeq NP_417663 NC_000913.3 # RefSeq WP_000922901 NZ_LN832404.1 # SIMILARITY Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. {ECO 0000305}. # SUBCELLULAR LOCATION YRBG_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.19.5:the ca(2+) cation antiporter (caca) family # TIGRFAMs TIGR00367 TIGR00367 # eggNOG COG0530 LUCA # eggNOG ENOG4105FEU Bacteria BLAST swissprot:YRBG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YRBG_ECOLI BioCyc ECOL316407:JW3163-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3163-MONOMER BioCyc EcoCyc:YRBG-MONOMER http://biocyc.org/getid?id=EcoCyc:YRBG-MONOMER COG COG0530 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0530 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2654 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2654 EcoGene EG12802 http://www.ecogene.org/geneInfo.php?eg_id=EG12802 EnsemblBacteria AAC76228 http://www.ensemblgenomes.org/id/AAC76228 EnsemblBacteria AAC76228 http://www.ensemblgenomes.org/id/AAC76228 EnsemblBacteria BAE77240 http://www.ensemblgenomes.org/id/BAE77240 EnsemblBacteria BAE77240 http://www.ensemblgenomes.org/id/BAE77240 EnsemblBacteria BAE77240 http://www.ensemblgenomes.org/id/BAE77240 EnsemblBacteria b3196 http://www.ensemblgenomes.org/id/b3196 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0005262 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005262 GO_function GO:0005509 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509 GO_function GO:0008273 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008273 GO_function GO:0030955 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030955 GO_function GO:0031402 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031402 GO_process GO:0006874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006874 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GeneID 947730 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947730 HOGENOM HOG000274121 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000274121&db=HOGENOM6 InParanoid P45394 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45394 InterPro IPR004481 http://www.ebi.ac.uk/interpro/entry/IPR004481 InterPro IPR004837 http://www.ebi.ac.uk/interpro/entry/IPR004837 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3163 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3163 KEGG_Gene eco:b3196 http://www.genome.jp/dbget-bin/www_bget?eco:b3196 KEGG_Orthology KO:K07301 http://www.genome.jp/dbget-bin/www_bget?KO:K07301 OMA EQMAELP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EQMAELP PANTHER PTHR10846 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10846 PSORT swissprot:YRBG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YRBG_ECOLI PSORT-B swissprot:YRBG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YRBG_ECOLI PSORT2 swissprot:YRBG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YRBG_ECOLI Pfam PF01699 http://pfam.xfam.org/family/PF01699 Phobius swissprot:YRBG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YRBG_ECOLI PhylomeDB P45394 http://phylomedb.org/?seqid=P45394 ProteinModelPortal P45394 http://www.proteinmodelportal.org/query/uniprot/P45394 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417663 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417663 RefSeq WP_000922901 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000922901 STRING 511145.b3196 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3196&targetmode=cogs STRING COG0530 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0530&targetmode=cogs TCDB 2.A.19.5 http://www.tcdb.org/search/result.php?tc=2.A.19.5 TIGRFAMs TIGR00367 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00367 UniProtKB YRBG_ECOLI http://www.uniprot.org/uniprot/YRBG_ECOLI UniProtKB-AC P45394 http://www.uniprot.org/uniprot/P45394 charge swissprot:YRBG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YRBG_ECOLI eggNOG COG0530 http://eggnogapi.embl.de/nog_data/html/tree/COG0530 eggNOG ENOG4105FEU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FEU epestfind swissprot:YRBG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YRBG_ECOLI garnier swissprot:YRBG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YRBG_ECOLI helixturnhelix swissprot:YRBG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YRBG_ECOLI hmoment swissprot:YRBG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YRBG_ECOLI iep swissprot:YRBG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YRBG_ECOLI inforesidue swissprot:YRBG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YRBG_ECOLI octanol swissprot:YRBG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YRBG_ECOLI pepcoil swissprot:YRBG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YRBG_ECOLI pepdigest swissprot:YRBG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YRBG_ECOLI pepinfo swissprot:YRBG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YRBG_ECOLI pepnet swissprot:YRBG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YRBG_ECOLI pepstats swissprot:YRBG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YRBG_ECOLI pepwheel swissprot:YRBG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YRBG_ECOLI pepwindow swissprot:YRBG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YRBG_ECOLI sigcleave swissprot:YRBG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YRBG_ECOLI ## Database ID URL or Descriptions # AltName HLYE_ECOLI Cytotoxin ClyA # AltName HLYE_ECOLI Hemolysis-inducing protein # AltName HLYE_ECOLI Latent pore-forming 34 kDa hemolysin # AltName HLYE_ECOLI Silent hemolysin SheA # BioGrid 4260100 4 # EcoGene EG13243 hlyE # FUNCTION HLYE_ECOLI Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells. {ECO 0000269|PubMed 14532000}. # GO_component GO:0005576 extracellular region; IMP:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_component GO:0020002 host cell plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0042597 periplasmic space; IMP:EcoCyc. # GO_function GO:0042802 identical protein binding; IPI:IntAct. # GO_process GO:0009405 pathogenesis; IDA:EcoliWiki. # GO_process GO:0044179 hemolysis in other organism; IDA:EcoCyc. # GO_process GO:0044532 modulation of apoptotic process in other organism; IDA:EcoliWiki. # GO_process GO:0051715 cytolysis in other organism; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005576 extracellular region # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0008150 biological_process # INDUCTION HLYE_ECOLI During anaerobic growth. Weakly or not expressed in most strains. It is activated by SlyA, while it is silenced by H- NS. Its expression is also regulated by CRP and FNR. {ECO 0000269|PubMed 10027972, ECO 0000269|PubMed 11053378, ECO 0000269|PubMed 12057949}. # INTERACTION HLYE_ECOLI Self; NbExp=4; IntAct=EBI-8516553, EBI-8516553; # InterPro IPR027018 Hemolysin_E # KEGG_Brite ko02042 Bacterial toxins # MASS SPECTROMETRY Mass=34940; Method=Electrospray; Range=2-303; Evidence={ECO:0000269|PubMed 11006277}; # Organism HLYE_ECOLI Escherichia coli (strain K12) # PATRIC 32117610 VBIEscCol129921_1227 # PDB 1QOY X-ray; 2.00 A; A=1-303 # PDB 2WCD X-ray; 3.29 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=2-303 # PDB 4PHO X-ray; 2.12 A; A/B/C=2-303 # PDB 4PHQ X-ray; 1.94 A; A/B/C/D=6-303 # PIR C64864 C64864 # PTM HLYE_ECOLI In periplasm, it forms a disulfide bond between Cys-87 and Cys-285, which prevents the oligomerization. In outer membrane vesicles, the redox status prevents formation of the disulfide bond, leading to oligomerization and pore formation. # Pfam PF06109 HlyE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HLYE_ECOLI Hemolysin E, chromosomal # RefSeq NP_415700 NC_000913.3 # RefSeq WP_001336523 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB07048.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA67204.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the hemolysin E family. {ECO 0000305}. # SUBCELLULAR LOCATION HLYE_ECOLI Secreted. Periplasm. Host cell membrane {ECO 0000305}; Single-pass membrane protein {ECO 0000305}. Note=Exported from the cell by outer membrane vesicles. Also found in the periplasmic space. # SUBUNIT Monomer and oligomer. In periplasm, it is present as a monomer, while in outer membrane vesicles, it oligomerizes to form a pore structure that is active. The pore is formed by a dodecamer. {ECO:0000269|PubMed 19421192}. # TCDB 1.C.10.1 the pore-forming haemolysin e (hlye) family # eggNOG ENOG4106PXS Bacteria # eggNOG ENOG410YAUV LUCA BLAST swissprot:HLYE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HLYE_ECOLI BioCyc ECOL316407:JW5181-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5181-MONOMER BioCyc EcoCyc:G6619-MONOMER http://biocyc.org/getid?id=EcoCyc:G6619-MONOMER DIP DIP-9915N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9915N DOI 10.1016/S0092-8674(00)81564-0 http://dx.doi.org/10.1016/S0092-8674(00)81564-0 DOI 10.1016/S0092-8674(03)00754-2 http://dx.doi.org/10.1016/S0092-8674(03)00754-2 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature08026 http://dx.doi.org/10.1038/nature08026 DOI 10.1046/j.1365-2958.1997.4391813.x http://dx.doi.org/10.1046/j.1365-2958.1997.4391813.x DOI 10.1046/j.1365-2958.1999.01196.x http://dx.doi.org/10.1046/j.1365-2958.1999.01196.x DOI 10.1046/j.1365-2958.1999.01435.x http://dx.doi.org/10.1046/j.1365-2958.1999.01435.x DOI 10.1074/jbc.M005420200 http://dx.doi.org/10.1074/jbc.M005420200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.22.6347-6357.2000 http://dx.doi.org/10.1128/JB.182.22.6347-6357.2000 DOI 10.1128/JB.184.13.3549-3559.2002 http://dx.doi.org/10.1128/JB.184.13.3549-3559.2002 DOI 10.1128/JB.185.18.5491-5499.2003 http://dx.doi.org/10.1128/JB.185.18.5491-5499.2003 EMBL AF240780 http://www.ebi.ac.uk/ena/data/view/AF240780 EMBL AJ001829 http://www.ebi.ac.uk/ena/data/view/AJ001829 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U13610 http://www.ebi.ac.uk/ena/data/view/U13610 EMBL U22466 http://www.ebi.ac.uk/ena/data/view/U22466 EMBL U57430 http://www.ebi.ac.uk/ena/data/view/U57430 EMBL U73842 http://www.ebi.ac.uk/ena/data/view/U73842 EMBL X98615 http://www.ebi.ac.uk/ena/data/view/X98615 EchoBASE EB3032 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3032 EcoGene EG13243 http://www.ecogene.org/geneInfo.php?eg_id=EG13243 EnsemblBacteria AAC74266 http://www.ensemblgenomes.org/id/AAC74266 EnsemblBacteria AAC74266 http://www.ensemblgenomes.org/id/AAC74266 EnsemblBacteria BAA36016 http://www.ensemblgenomes.org/id/BAA36016 EnsemblBacteria BAA36016 http://www.ensemblgenomes.org/id/BAA36016 EnsemblBacteria BAA36016 http://www.ensemblgenomes.org/id/BAA36016 EnsemblBacteria b1182 http://www.ensemblgenomes.org/id/b1182 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005576 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0020002 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0020002 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0009405 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009405 GO_process GO:0044179 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044179 GO_process GO:0044532 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044532 GO_process GO:0051715 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051715 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005576 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 945745 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945745 HOGENOM HOG000051663 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000051663&db=HOGENOM6 InParanoid P77335 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77335 InterPro IPR027018 http://www.ebi.ac.uk/interpro/entry/IPR027018 KEGG_Brite ko02042 http://www.genome.jp/dbget-bin/www_bget?ko02042 KEGG_Gene ecj:JW5181 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5181 KEGG_Gene eco:b1182 http://www.genome.jp/dbget-bin/www_bget?eco:b1182 KEGG_Orthology KO:K11139 http://www.genome.jp/dbget-bin/www_bget?KO:K11139 MINT MINT-2737936 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-2737936 OMA RCAIREY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RCAIREY PDB 1QOY http://www.ebi.ac.uk/pdbe-srv/view/entry/1QOY PDB 2WCD http://www.ebi.ac.uk/pdbe-srv/view/entry/2WCD PDB 4PHO http://www.ebi.ac.uk/pdbe-srv/view/entry/4PHO PDB 4PHQ http://www.ebi.ac.uk/pdbe-srv/view/entry/4PHQ PDBsum 1QOY http://www.ebi.ac.uk/pdbsum/1QOY PDBsum 2WCD http://www.ebi.ac.uk/pdbsum/2WCD PDBsum 4PHO http://www.ebi.ac.uk/pdbsum/4PHO PDBsum 4PHQ http://www.ebi.ac.uk/pdbsum/4PHQ PSORT swissprot:HLYE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HLYE_ECOLI PSORT-B swissprot:HLYE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HLYE_ECOLI PSORT2 swissprot:HLYE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HLYE_ECOLI Pfam PF06109 http://pfam.xfam.org/family/PF06109 Phobius swissprot:HLYE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HLYE_ECOLI ProteinModelPortal P77335 http://www.proteinmodelportal.org/query/uniprot/P77335 PubMed 10027972 http://www.ncbi.nlm.nih.gov/pubmed/10027972 PubMed 10383763 http://www.ncbi.nlm.nih.gov/pubmed/10383763 PubMed 10660049 http://www.ncbi.nlm.nih.gov/pubmed/10660049 PubMed 11006277 http://www.ncbi.nlm.nih.gov/pubmed/11006277 PubMed 11053378 http://www.ncbi.nlm.nih.gov/pubmed/11053378 PubMed 11902713 http://www.ncbi.nlm.nih.gov/pubmed/11902713 PubMed 12057949 http://www.ncbi.nlm.nih.gov/pubmed/12057949 PubMed 12949101 http://www.ncbi.nlm.nih.gov/pubmed/12949101 PubMed 14532000 http://www.ncbi.nlm.nih.gov/pubmed/14532000 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19421192 http://www.ncbi.nlm.nih.gov/pubmed/19421192 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415700 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415700 RefSeq WP_001336523 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001336523 SMR P77335 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77335 STRING 511145.b1182 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1182&targetmode=cogs TCDB 1.C.10.1 http://www.tcdb.org/search/result.php?tc=1.C.10.1 UniProtKB HLYE_ECOLI http://www.uniprot.org/uniprot/HLYE_ECOLI UniProtKB-AC P77335 http://www.uniprot.org/uniprot/P77335 charge swissprot:HLYE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HLYE_ECOLI eggNOG ENOG4106PXS http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106PXS eggNOG ENOG410YAUV http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YAUV epestfind swissprot:HLYE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HLYE_ECOLI garnier swissprot:HLYE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HLYE_ECOLI helixturnhelix swissprot:HLYE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HLYE_ECOLI hmoment swissprot:HLYE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HLYE_ECOLI iep swissprot:HLYE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HLYE_ECOLI inforesidue swissprot:HLYE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HLYE_ECOLI octanol swissprot:HLYE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HLYE_ECOLI pepcoil swissprot:HLYE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HLYE_ECOLI pepdigest swissprot:HLYE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HLYE_ECOLI pepinfo swissprot:HLYE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HLYE_ECOLI pepnet swissprot:HLYE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HLYE_ECOLI pepstats swissprot:HLYE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HLYE_ECOLI pepwheel swissprot:HLYE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HLYE_ECOLI pepwindow swissprot:HLYE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HLYE_ECOLI sigcleave swissprot:HLYE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HLYE_ECOLI ## Database ID URL or Descriptions # AltName Isochorismate mutase {ECO 0000305} # BIOPHYSICOCHEMICAL PROPERTIES ENTC_ECOLI Kinetic parameters KM=5 uM for isochorismate (at pH 7.8 and 37 degrees Celsius) {ECO 0000269|PubMed 2139795}; KM=7 uM for chorismate {ECO 0000269|PubMed 20079748}; KM=14 uM for chorismate (at pH 7.8 and 37 degrees Celsius) {ECO 0000269|PubMed 2139795}; KM=41 uM for chorismate {ECO 0000269|PubMed 17243787}; Note=Kcat is 290 min(-1) for mutase activity with chorismate. Kcat is 173 min(-1) for mutase activity with chorismate (at pH 7.8 and 37 degrees Celsius). Kcat is 108 min(-1) for mutase activity with isochorismate (at pH 7.8 and 37 degrees Celsius). Kcat is 37 min(-1) for mutase activity with chorismate. {ECO 0000269|PubMed 17243787, ECO 0000269|PubMed 20079748, ECO 0000269|PubMed 2139795}; # BRENDA 5.4.4 2026 # BioGrid 4260986 156 # CATALYTIC ACTIVITY ENTC_ECOLI Chorismate = isochorismate. {ECO 0000269|PubMed 17243787, ECO 0000269|PubMed 20079748, ECO 0000269|PubMed 2139795}. # COFACTOR ENTC_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 20079748}; # DISRUPTION PHENOTYPE ENTC_ECOLI Cells lacking this gene are unable to produce enterobactin and are hypersensitive to the antimicrobial peptide wrwycr. {ECO 0000269|PubMed 22096151, ECO 0000269|PubMed 9795253}. # EcoGene EG10261 entC # FUNCTION ENTC_ECOLI Involved in the biosynthesis of the siderophore enterobactin (macrocyclic trimeric lactone of N-(2,3- dihydroxybenzoyl)-serine). Catalyzes the reversible conversion of chorismate to isochorismate. {ECO 0000269|PubMed 17243787, ECO 0000269|PubMed 20079748, ECO 0000269|PubMed 2139795, ECO 0000269|PubMed 2536681, ECO 0000269|PubMed 8655506, ECO 0000269|PubMed 9795253}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0000287 magnesium ion binding; IDA:UniProtKB. # GO_function GO:0008909 isochorismate synthase activity; IDA:EcoCyc. # GO_process GO:0009239 enterobactin biosynthetic process; IMP:EcoCyc. # GO_process GO:0009697 salicylic acid biosynthetic process; IBA:GO_Central. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0019748 secondary metabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.60.120.10 -; 1. # INDUCTION ENTC_ECOLI Under conditions of iron deficiency and by the fur protein. {ECO 0000269|PubMed 2521621, ECO 0000269|PubMed 8655506}. # IntAct P0AEJ2 9 # InterPro IPR004561 IsoChor_synthase # InterPro IPR005801 ADC_synthase # InterPro IPR015890 Chorismate_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00130 Ubiquinone and other terpenoid-quinone biosynthesis # KEGG_Pathway ko01053 Biosynthesis of siderophore group nonribosomal peptides # Organism ENTC_ECOLI Escherichia coli (strain K12) # PATHWAY Siderophore biosynthesis; enterobactin biosynthesis. {ECO 0000305}. # PATRIC 32116362 VBIEscCol129921_0621 # PDB 3HWO X-ray; 2.30 A; A/B=1-391 # PDB 5JXZ X-ray; 1.88 A; A/B=1-391 # PDB 5JY4 X-ray; 2.11 A; A/B=1-391 # PDB 5JY8 X-ray; 2.94 A; A/B=1-391 # PDB 5JZD X-ray; 2.30 A; A/B=1-391 # PIR JT0497 SYECIK # Pfam PF00425 Chorismate_bind # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Isochorismate synthase EntC {ECO:0000303|PubMed 2536681} # RefSeq NP_415125 NC_000913.3 # RefSeq WP_000381303 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40793.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the isochorismate synthase family. {ECO 0000305}. # SUBUNIT ENTC_ECOLI Monomer. {ECO 0000269|PubMed 20079748, ECO 0000269|PubMed 2139795}. # SUPFAM SSF56322 SSF56322 # TIGRFAMs TIGR00543 isochor_syn # eggNOG COG1169 LUCA # eggNOG ENOG4105E4F Bacteria BLAST swissprot:ENTC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ENTC_ECOLI BioCyc ECOL316407:JW0585-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0585-MONOMER BioCyc EcoCyc:ENTC-MONOMER http://biocyc.org/getid?id=EcoCyc:ENTC-MONOMER BioCyc MetaCyc:ENTC-MONOMER http://biocyc.org/getid?id=MetaCyc:ENTC-MONOMER COG COG1169 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1169 DIP DIP-47970N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47970N DOI 10.1016/0022-2836(90)90229-F http://dx.doi.org/10.1016/0022-2836(90)90229-F DOI 10.1016/0378-1097(90)90120-F http://dx.doi.org/10.1016/0378-1097(90)90120-F DOI 10.1016/S0304-4165(98)00089-0 http://dx.doi.org/10.1016/S0304-4165(98)00089-0 DOI 10.1016/j.jmb.2010.01.019 http://dx.doi.org/10.1016/j.jmb.2010.01.019 DOI 10.1021/bi00458a012 http://dx.doi.org/10.1021/bi00458a012 DOI 10.1021/ja065064+ http://dx.doi.org/10.1021/ja065064+ DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1099/mic.0.054361-0 http://dx.doi.org/10.1099/mic.0.054361-0 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.4.4.2 {ECO:0000269|PubMed:17243787, ECO:0000269|PubMed:20079748, ECO:0000269|PubMed:2139795} http://www.genome.jp/dbget-bin/www_bget?EC:5.4.4.2 {ECO:0000269|PubMed:17243787, ECO:0000269|PubMed:20079748, ECO:0000269|PubMed:2139795} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M24142 http://www.ebi.ac.uk/ena/data/view/M24142 EMBL M36700 http://www.ebi.ac.uk/ena/data/view/M36700 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EMBL X53274 http://www.ebi.ac.uk/ena/data/view/X53274 ENZYME 5.4.4.2 {ECO:0000269|PubMed:17243787, ECO:0000269|PubMed:20079748, ECO:0000269|PubMed:2139795} http://enzyme.expasy.org/EC/5.4.4.2 {ECO:0000269|PubMed:17243787, ECO:0000269|PubMed:20079748, ECO:0000269|PubMed:2139795} EchoBASE EB0257 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0257 EcoGene EG10261 http://www.ecogene.org/geneInfo.php?eg_id=EG10261 EnsemblBacteria AAC73694 http://www.ensemblgenomes.org/id/AAC73694 EnsemblBacteria AAC73694 http://www.ensemblgenomes.org/id/AAC73694 EnsemblBacteria BAE76348 http://www.ensemblgenomes.org/id/BAE76348 EnsemblBacteria BAE76348 http://www.ensemblgenomes.org/id/BAE76348 EnsemblBacteria BAE76348 http://www.ensemblgenomes.org/id/BAE76348 EnsemblBacteria b0593 http://www.ensemblgenomes.org/id/b0593 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0008909 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008909 GO_process GO:0009239 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009239 GO_process GO:0009697 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009697 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0019748 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019748 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.60.120.10 http://www.cathdb.info/version/latest/superfamily/3.60.120.10 GeneID 945511 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945511 HOGENOM HOG000028185 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000028185&db=HOGENOM6 InParanoid P0AEJ2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEJ2 IntAct P0AEJ2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEJ2* IntEnz 5.4.4.2 {ECO:0000269|PubMed:17243787, ECO:0000269|PubMed:20079748, ECO:0000269|PubMed:2139795} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.4.4.2 {ECO:0000269|PubMed:17243787, ECO:0000269|PubMed:20079748, ECO:0000269|PubMed:2139795} InterPro IPR004561 http://www.ebi.ac.uk/interpro/entry/IPR004561 InterPro IPR005801 http://www.ebi.ac.uk/interpro/entry/IPR005801 InterPro IPR015890 http://www.ebi.ac.uk/interpro/entry/IPR015890 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0585 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0585 KEGG_Gene eco:b0593 http://www.genome.jp/dbget-bin/www_bget?eco:b0593 KEGG_Orthology KO:K02361 http://www.genome.jp/dbget-bin/www_bget?KO:K02361 KEGG_Pathway ko00130 http://www.genome.jp/kegg-bin/show_pathway?ko00130 KEGG_Pathway ko01053 http://www.genome.jp/kegg-bin/show_pathway?ko01053 KEGG_Reaction rn:R01717 http://www.genome.jp/dbget-bin/www_bget?rn:R01717 MINT MINT-1300552 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1300552 OMA MWHLSSR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MWHLSSR PDB 3HWO http://www.ebi.ac.uk/pdbe-srv/view/entry/3HWO PDB 5JXZ http://www.ebi.ac.uk/pdbe-srv/view/entry/5JXZ PDB 5JY4 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JY4 PDB 5JY8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JY8 PDB 5JZD http://www.ebi.ac.uk/pdbe-srv/view/entry/5JZD PDBsum 3HWO http://www.ebi.ac.uk/pdbsum/3HWO PDBsum 5JXZ http://www.ebi.ac.uk/pdbsum/5JXZ PDBsum 5JY4 http://www.ebi.ac.uk/pdbsum/5JY4 PDBsum 5JY8 http://www.ebi.ac.uk/pdbsum/5JY8 PDBsum 5JZD http://www.ebi.ac.uk/pdbsum/5JZD PSORT swissprot:ENTC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ENTC_ECOLI PSORT-B swissprot:ENTC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ENTC_ECOLI PSORT2 swissprot:ENTC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ENTC_ECOLI Pfam PF00425 http://pfam.xfam.org/family/PF00425 Phobius swissprot:ENTC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ENTC_ECOLI PhylomeDB P0AEJ2 http://phylomedb.org/?seqid=P0AEJ2 ProteinModelPortal P0AEJ2 http://www.proteinmodelportal.org/query/uniprot/P0AEJ2 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17243787 http://www.ncbi.nlm.nih.gov/pubmed/17243787 PubMed 20079748 http://www.ncbi.nlm.nih.gov/pubmed/20079748 PubMed 2110093 http://www.ncbi.nlm.nih.gov/pubmed/2110093 PubMed 2139473 http://www.ncbi.nlm.nih.gov/pubmed/2139473 PubMed 2139795 http://www.ncbi.nlm.nih.gov/pubmed/2139795 PubMed 22096151 http://www.ncbi.nlm.nih.gov/pubmed/22096151 PubMed 2521621 http://www.ncbi.nlm.nih.gov/pubmed/2521621 PubMed 2536681 http://www.ncbi.nlm.nih.gov/pubmed/2536681 PubMed 8655506 http://www.ncbi.nlm.nih.gov/pubmed/8655506 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9795253 http://www.ncbi.nlm.nih.gov/pubmed/9795253 RefSeq NP_415125 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415125 RefSeq WP_000381303 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000381303 SMR P0AEJ2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEJ2 STRING 511145.b0593 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0593&targetmode=cogs STRING COG1169 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1169&targetmode=cogs SUPFAM SSF56322 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56322 TIGRFAMs TIGR00543 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00543 UniProtKB ENTC_ECOLI http://www.uniprot.org/uniprot/ENTC_ECOLI UniProtKB-AC P0AEJ2 http://www.uniprot.org/uniprot/P0AEJ2 charge swissprot:ENTC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ENTC_ECOLI eggNOG COG1169 http://eggnogapi.embl.de/nog_data/html/tree/COG1169 eggNOG ENOG4105E4F http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E4F epestfind swissprot:ENTC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ENTC_ECOLI garnier swissprot:ENTC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ENTC_ECOLI helixturnhelix swissprot:ENTC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ENTC_ECOLI hmoment swissprot:ENTC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ENTC_ECOLI iep swissprot:ENTC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ENTC_ECOLI inforesidue swissprot:ENTC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ENTC_ECOLI octanol swissprot:ENTC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ENTC_ECOLI pepcoil swissprot:ENTC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ENTC_ECOLI pepdigest swissprot:ENTC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ENTC_ECOLI pepinfo swissprot:ENTC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ENTC_ECOLI pepnet swissprot:ENTC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ENTC_ECOLI pepstats swissprot:ENTC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ENTC_ECOLI pepwheel swissprot:ENTC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ENTC_ECOLI pepwindow swissprot:ENTC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ENTC_ECOLI sigcleave swissprot:ENTC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ENTC_ECOLI ## Database ID URL or Descriptions # BRENDA 3.6.3.33 2026 # BioGrid 4263152 131 # EcoGene EG10127 btuC # FUNCTION BTUC_ECOLI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:EcoliWiki. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IDA:EcoCyc. # GO_function GO:0015235 cobalamin transporter activity; IMP:EcoliWiki. # GO_function GO:0015420 cobalamin-transporting ATPase activity; IDA:EcoCyc. # GO_process GO:0015889 cobalamin transport; IMP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # Gene3D 1.10.3470.10 -; 1. # HAMAP MF_01004 BtuC # INTERACTION BTUC_ECOLI P06611 btuD; NbExp=3; IntAct=EBI-1033427, EBI-1033420; # IntAct P06609 2 # InterPro IPR000522 ABC_transptr_FecCD # InterPro IPR023691 ABC_transptr_BtuC # InterPro IPR029022 ABC_BtuC-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00241 Vitamin B12 transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism BTUC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30472 PTHR30472 # PATRIC 32118728 VBIEscCol129921_1782 # PDB 1L7V X-ray; 3.20 A; A/B=1-326 # PDB 2QI9 X-ray; 2.60 A; A/B=1-326 # PDB 4DBL X-ray; 3.49 A; A/B/F/G=1-326 # PDB 4FI3 X-ray; 3.47 A; A/B=1-326 # PDB 4R9U X-ray; 2.78 A; A/B=1-326 # PIR G64929 QRECBC # Pfam PF01032 FecCD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BTUC_ECOLI Vitamin B12 import system permease protein BtuC # RefSeq NP_416226 NC_000913.3 # RefSeq WP_000956528 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION BTUC_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUBUNIT The complex is composed of two ATP-binding proteins (BtuD), two transmembrane proteins (BtuC) and a solute-binding protein (BtuF). {ECO:0000269|PubMed 12004122}. # SUPFAM SSF81345 SSF81345 # TCDB 3.A.1.13 the atp-binding cassette (abc) superfamily # eggNOG COG4139 LUCA # eggNOG ENOG4108ESU Bacteria BLAST swissprot:BTUC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BTUC_ECOLI BioCyc ECOL316407:JW1701-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1701-MONOMER BioCyc EcoCyc:BTUC-MONOMER http://biocyc.org/getid?id=EcoCyc:BTUC-MONOMER BioCyc MetaCyc:BTUC-MONOMER http://biocyc.org/getid?id=MetaCyc:BTUC-MONOMER COG COG4139 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4139 DIP DIP-9233N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9233N DOI 10.1007/BF02464897 http://dx.doi.org/10.1007/BF02464897 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1071142 http://dx.doi.org/10.1126/science.1071142 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.3.706-717.2002 http://dx.doi.org/10.1128/JB.184.3.706-717.2002 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M14031 http://www.ebi.ac.uk/ena/data/view/M14031 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0125 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0125 EcoGene EG10127 http://www.ecogene.org/geneInfo.php?eg_id=EG10127 EnsemblBacteria AAC74781 http://www.ensemblgenomes.org/id/AAC74781 EnsemblBacteria AAC74781 http://www.ensemblgenomes.org/id/AAC74781 EnsemblBacteria BAA15479 http://www.ensemblgenomes.org/id/BAA15479 EnsemblBacteria BAA15479 http://www.ensemblgenomes.org/id/BAA15479 EnsemblBacteria BAA15479 http://www.ensemblgenomes.org/id/BAA15479 EnsemblBacteria b1711 http://www.ensemblgenomes.org/id/b1711 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0015235 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015235 GO_function GO:0015420 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015420 GO_process GO:0015889 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015889 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 1.10.3470.10 http://www.cathdb.info/version/latest/superfamily/1.10.3470.10 GeneID 945877 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945877 HAMAP MF_01004 http://hamap.expasy.org/unirule/MF_01004 HOGENOM HOG000045407 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000045407&db=HOGENOM6 InParanoid P06609 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P06609 IntAct P06609 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P06609* InterPro IPR000522 http://www.ebi.ac.uk/interpro/entry/IPR000522 InterPro IPR023691 http://www.ebi.ac.uk/interpro/entry/IPR023691 InterPro IPR029022 http://www.ebi.ac.uk/interpro/entry/IPR029022 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1701 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1701 KEGG_Gene eco:b1711 http://www.genome.jp/dbget-bin/www_bget?eco:b1711 KEGG_Orthology KO:K06073 http://www.genome.jp/dbget-bin/www_bget?KO:K06073 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 MINT MINT-6803761 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-6803761 OMA GMQARAL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GMQARAL PANTHER PTHR30472 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30472 PDB 1L7V http://www.ebi.ac.uk/pdbe-srv/view/entry/1L7V PDB 2QI9 http://www.ebi.ac.uk/pdbe-srv/view/entry/2QI9 PDB 4DBL http://www.ebi.ac.uk/pdbe-srv/view/entry/4DBL PDB 4FI3 http://www.ebi.ac.uk/pdbe-srv/view/entry/4FI3 PDB 4R9U http://www.ebi.ac.uk/pdbe-srv/view/entry/4R9U PDBsum 1L7V http://www.ebi.ac.uk/pdbsum/1L7V PDBsum 2QI9 http://www.ebi.ac.uk/pdbsum/2QI9 PDBsum 4DBL http://www.ebi.ac.uk/pdbsum/4DBL PDBsum 4FI3 http://www.ebi.ac.uk/pdbsum/4FI3 PDBsum 4R9U http://www.ebi.ac.uk/pdbsum/4R9U PSORT swissprot:BTUC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BTUC_ECOLI PSORT-B swissprot:BTUC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BTUC_ECOLI PSORT2 swissprot:BTUC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BTUC_ECOLI Pfam PF01032 http://pfam.xfam.org/family/PF01032 Phobius swissprot:BTUC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BTUC_ECOLI PhylomeDB P06609 http://phylomedb.org/?seqid=P06609 ProteinModelPortal P06609 http://www.proteinmodelportal.org/query/uniprot/P06609 PubMed 11790740 http://www.ncbi.nlm.nih.gov/pubmed/11790740 PubMed 12004122 http://www.ncbi.nlm.nih.gov/pubmed/12004122 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2671656 http://www.ncbi.nlm.nih.gov/pubmed/2671656 PubMed 3528129 http://www.ncbi.nlm.nih.gov/pubmed/3528129 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416226 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416226 RefSeq WP_000956528 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000956528 SMR P06609 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P06609 STRING 511145.b1711 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1711&targetmode=cogs STRING COG4139 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4139&targetmode=cogs SUPFAM SSF81345 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81345 TCDB 3.A.1.13 http://www.tcdb.org/search/result.php?tc=3.A.1.13 UniProtKB BTUC_ECOLI http://www.uniprot.org/uniprot/BTUC_ECOLI UniProtKB-AC P06609 http://www.uniprot.org/uniprot/P06609 charge swissprot:BTUC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BTUC_ECOLI eggNOG COG4139 http://eggnogapi.embl.de/nog_data/html/tree/COG4139 eggNOG ENOG4108ESU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ESU epestfind swissprot:BTUC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BTUC_ECOLI garnier swissprot:BTUC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BTUC_ECOLI helixturnhelix swissprot:BTUC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BTUC_ECOLI hmoment swissprot:BTUC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BTUC_ECOLI iep swissprot:BTUC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BTUC_ECOLI inforesidue swissprot:BTUC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BTUC_ECOLI octanol swissprot:BTUC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BTUC_ECOLI pepcoil swissprot:BTUC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BTUC_ECOLI pepdigest swissprot:BTUC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BTUC_ECOLI pepinfo swissprot:BTUC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BTUC_ECOLI pepnet swissprot:BTUC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BTUC_ECOLI pepstats swissprot:BTUC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BTUC_ECOLI pepwheel swissprot:BTUC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BTUC_ECOLI pepwindow swissprot:BTUC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BTUC_ECOLI sigcleave swissprot:BTUC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BTUC_ECOLI ## Database ID URL or Descriptions # AltName Sulfate-transporting ATPase {ECO:0000255|HAMAP-Rule MF_01701} # BioGrid 4260755 15 # CATALYTIC ACTIVITY ATP + H(2)O + sulfate(Out) = ADP + phosphate + sulfate(In). {ECO:0000255|HAMAP-Rule MF_01701}. # CDD cd03296 ABC_CysA_sulfate_importer # EcoGene EG10183 cysA # FUNCTION CYSA_ECOLI Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IEA:UniProtKB-HAMAP. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0015419 ATPase-coupled sulfate transmembrane transporter activity; IEA:UniProtKB-HAMAP. # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.300 -; 1. # IntAct P16676 4 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR005666 Sulph_transpt1 # InterPro IPR008995 Mo/tungstate-bd_C_term_dom # InterPro IPR014769 ABC_CysA_ATP-bd_C # InterPro IPR017871 ABC_transporter_CS # InterPro IPR024765 TOBE-like # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00185 Sulfate transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # MISCELLANEOUS CYSA_ECOLI CysPTWAM system can also transport molybdate. # Organism CYSA_ECOLI Escherichia coli (strain K12) # PATRIC 32120229 VBIEscCol129921_2517 # PIR E65016 QRECSA # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # PROSITE PS51237 CYSA # Pfam PF00005 ABC_tran # Pfam PF12857 TOBE_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Sulfate/thiosulfate import ATP-binding protein CysA {ECO:0000255|HAMAP-Rule MF_01701} # RefSeq NP_416917 NC_000913.3 # RefSeq WP_000021036 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. Sulfate/tungstate importer (TC 3.A.1.6) family. {ECO:0000255|HAMAP-Rule MF_01701}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|HAMAP- Rule MF_01701}. # SMART SM00382 AAA # SUBCELLULAR LOCATION CYSA_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01701}; Peripheral membrane protein {ECO 0000255|HAMAP- Rule MF_01701}. # SUBUNIT The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute- binding protein (CysP). {ECO:0000255|HAMAP-Rule MF_01701}. # SUPFAM SSF50331 SSF50331 # SUPFAM SSF52540 SSF52540 # TCDB 3.A.1.6 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR00968 3a0106s01 # eggNOG COG1118 LUCA # eggNOG ENOG4108IJ6 Bacteria BLAST swissprot:CYSA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CYSA_ECOLI BioCyc ECOL316407:JW2415-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2415-MONOMER BioCyc EcoCyc:CYSA-MONOMER http://biocyc.org/getid?id=EcoCyc:CYSA-MONOMER BioCyc MetaCyc:CYSA-MONOMER http://biocyc.org/getid?id=MetaCyc:CYSA-MONOMER COG COG1118 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1118 DIP DIP-9373N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9373N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.3.25 {ECO:0000255|HAMAP-Rule:MF_01701} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.25 {ECO:0000255|HAMAP-Rule:MF_01701} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M32101 http://www.ebi.ac.uk/ena/data/view/M32101 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.6.3.25 {ECO:0000255|HAMAP-Rule:MF_01701} http://enzyme.expasy.org/EC/3.6.3.25 {ECO:0000255|HAMAP-Rule:MF_01701} EchoBASE EB0180 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0180 EcoGene EG10183 http://www.ecogene.org/geneInfo.php?eg_id=EG10183 EnsemblBacteria AAC75475 http://www.ensemblgenomes.org/id/AAC75475 EnsemblBacteria AAC75475 http://www.ensemblgenomes.org/id/AAC75475 EnsemblBacteria BAA16296 http://www.ensemblgenomes.org/id/BAA16296 EnsemblBacteria BAA16296 http://www.ensemblgenomes.org/id/BAA16296 EnsemblBacteria BAA16296 http://www.ensemblgenomes.org/id/BAA16296 EnsemblBacteria b2422 http://www.ensemblgenomes.org/id/b2422 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0015419 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015419 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 946889 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946889 InParanoid P16676 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P16676 IntAct P16676 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P16676* IntEnz 3.6.3.25 {ECO:0000255|HAMAP-Rule:MF_01701} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.25 {ECO:0000255|HAMAP-Rule:MF_01701} InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR005666 http://www.ebi.ac.uk/interpro/entry/IPR005666 InterPro IPR008995 http://www.ebi.ac.uk/interpro/entry/IPR008995 InterPro IPR014769 http://www.ebi.ac.uk/interpro/entry/IPR014769 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR024765 http://www.ebi.ac.uk/interpro/entry/IPR024765 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2415 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2415 KEGG_Gene eco:b2422 http://www.genome.jp/dbget-bin/www_bget?eco:b2422 KEGG_Orthology KO:K02045 http://www.genome.jp/dbget-bin/www_bget?KO:K02045 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 MINT MINT-1267862 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1267862 OMA HDDMHIT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HDDMHIT PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PROSITE PS51237 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51237 PSORT swissprot:CYSA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CYSA_ECOLI PSORT-B swissprot:CYSA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CYSA_ECOLI PSORT2 swissprot:CYSA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CYSA_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Pfam PF12857 http://pfam.xfam.org/family/PF12857 Phobius swissprot:CYSA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CYSA_ECOLI PhylomeDB P16676 http://phylomedb.org/?seqid=P16676 ProteinModelPortal P16676 http://www.proteinmodelportal.org/query/uniprot/P16676 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2188958 http://www.ncbi.nlm.nih.gov/pubmed/2188958 PubMed 7665461 http://www.ncbi.nlm.nih.gov/pubmed/7665461 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416917 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416917 RefSeq WP_000021036 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000021036 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P16676 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P16676 STRING 511145.b2422 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2422&targetmode=cogs STRING COG1118 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1118&targetmode=cogs SUPFAM SSF50331 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50331 SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.6 http://www.tcdb.org/search/result.php?tc=3.A.1.6 TIGRFAMs TIGR00968 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00968 UniProtKB CYSA_ECOLI http://www.uniprot.org/uniprot/CYSA_ECOLI UniProtKB-AC P16676 http://www.uniprot.org/uniprot/P16676 charge swissprot:CYSA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CYSA_ECOLI eggNOG COG1118 http://eggnogapi.embl.de/nog_data/html/tree/COG1118 eggNOG ENOG4108IJ6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108IJ6 epestfind swissprot:CYSA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CYSA_ECOLI garnier swissprot:CYSA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CYSA_ECOLI helixturnhelix swissprot:CYSA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CYSA_ECOLI hmoment swissprot:CYSA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CYSA_ECOLI iep swissprot:CYSA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CYSA_ECOLI inforesidue swissprot:CYSA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CYSA_ECOLI octanol swissprot:CYSA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CYSA_ECOLI pepcoil swissprot:CYSA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CYSA_ECOLI pepdigest swissprot:CYSA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CYSA_ECOLI pepinfo swissprot:CYSA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CYSA_ECOLI pepnet swissprot:CYSA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CYSA_ECOLI pepstats swissprot:CYSA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CYSA_ECOLI pepwheel swissprot:CYSA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CYSA_ECOLI pepwindow swissprot:CYSA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CYSA_ECOLI sigcleave swissprot:CYSA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CYSA_ECOLI ## Database ID URL or Descriptions # AltName YHHH_ECOLI ORF-B2 # BioGrid 4262511 252 # EcoGene EG11520 yhhH # IntAct P28911 3 # InterPro IPR028921 NTF2_fold_dom # Organism YHHH_ECOLI Escherichia coli (strain K12) # PATRIC 32122410 VBIEscCol129921_3582 # PIR A36902 A36902 # PIR S47702 S47702 # Pfam PF15631 Imm-NTF2-2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHHH_ECOLI Uncharacterized protein YhhH # RefSeq NP_417940 NC_000913.3 # RefSeq WP_001271686 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18458.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; BLAST swissprot:YHHH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHHH_ECOLI BioCyc ECOL316407:JW3449-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3449-MONOMER BioCyc EcoCyc:EG11520-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11520-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L02370 http://www.ebi.ac.uk/ena/data/view/L02370 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U16247 http://www.ebi.ac.uk/ena/data/view/U16247 EchoBASE EB1482 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1482 EcoGene EG11520 http://www.ecogene.org/geneInfo.php?eg_id=EG11520 EnsemblBacteria AAC76508 http://www.ensemblgenomes.org/id/AAC76508 EnsemblBacteria AAC76508 http://www.ensemblgenomes.org/id/AAC76508 EnsemblBacteria BAE77810 http://www.ensemblgenomes.org/id/BAE77810 EnsemblBacteria BAE77810 http://www.ensemblgenomes.org/id/BAE77810 EnsemblBacteria BAE77810 http://www.ensemblgenomes.org/id/BAE77810 EnsemblBacteria b3483 http://www.ensemblgenomes.org/id/b3483 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947993 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947993 HOGENOM HOG000050915 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000050915&db=HOGENOM6 IntAct P28911 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P28911* InterPro IPR028921 http://www.ebi.ac.uk/interpro/entry/IPR028921 KEGG_Gene ecj:JW3449 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3449 KEGG_Gene eco:b3483 http://www.genome.jp/dbget-bin/www_bget?eco:b3483 PSORT swissprot:YHHH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHHH_ECOLI PSORT-B swissprot:YHHH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHHH_ECOLI PSORT2 swissprot:YHHH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHHH_ECOLI Pfam PF15631 http://pfam.xfam.org/family/PF15631 Phobius swissprot:YHHH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHHH_ECOLI ProteinModelPortal P28911 http://www.proteinmodelportal.org/query/uniprot/P28911 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 8387990 http://www.ncbi.nlm.nih.gov/pubmed/8387990 PubMed 8536964 http://www.ncbi.nlm.nih.gov/pubmed/8536964 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417940 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417940 RefSeq WP_001271686 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001271686 SMR P28911 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P28911 STRING 511145.b3483 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3483&targetmode=cogs UniProtKB YHHH_ECOLI http://www.uniprot.org/uniprot/YHHH_ECOLI UniProtKB-AC P28911 http://www.uniprot.org/uniprot/P28911 charge swissprot:YHHH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHHH_ECOLI epestfind swissprot:YHHH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHHH_ECOLI garnier swissprot:YHHH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHHH_ECOLI helixturnhelix swissprot:YHHH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHHH_ECOLI hmoment swissprot:YHHH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHHH_ECOLI iep swissprot:YHHH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHHH_ECOLI inforesidue swissprot:YHHH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHHH_ECOLI octanol swissprot:YHHH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHHH_ECOLI pepcoil swissprot:YHHH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHHH_ECOLI pepdigest swissprot:YHHH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHHH_ECOLI pepinfo swissprot:YHHH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHHH_ECOLI pepnet swissprot:YHHH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHHH_ECOLI pepstats swissprot:YHHH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHHH_ECOLI pepwheel swissprot:YHHH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHHH_ECOLI pepwindow swissprot:YHHH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHHH_ECOLI sigcleave swissprot:YHHH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHHH_ECOLI ## Database ID URL or Descriptions # BioGrid 4259275 73 # EcoGene EG12790 yhbU # GO_function GO:0008233 peptidase activity; IEA:UniProtKB-KW. # GOslim_function GO:0008233 peptidase activity # INTERACTION YHBU_ECOLI P0A6F5 groL; NbExp=3; IntAct=EBI-561157, EBI-543750; # IntAct P45527 11 # InterPro IPR001539 Peptidase_U32 # InterPro IPR022998 ThiaminP_synth_SF # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01002 Peptidases # KEGG_Pathway ko05120 Epithelial cell signaling in Helicobacter pylori infection # Organism YHBU_ECOLI Escherichia coli (strain K12) # PATRIC 32121734 VBIEscCol129921_3253 # PIR B65106 B65106 # PROSITE PS01276 PEPTIDASE_U32 # Pfam PF01136 Peptidase_U32 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHBU_ECOLI Uncharacterized protease YhbU # RefSeq NP_417627 NC_000913.3 # RefSeq WP_001311152 NZ_LN832404.1 # SIMILARITY Belongs to the peptidase U32 family. {ECO 0000305}. # SUPFAM SSF51391 SSF51391 # eggNOG COG0826 LUCA # eggNOG ENOG4105CFP Bacteria BLAST swissprot:YHBU_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHBU_ECOLI BioCyc ECOL316407:JW3127-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3127-MONOMER BioCyc EcoCyc:G7652-MONOMER http://biocyc.org/getid?id=EcoCyc:G7652-MONOMER COG COG0826 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0826 DIP DIP-12268N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12268N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.4.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.4.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 3.4.-.- http://enzyme.expasy.org/EC/3.4.-.- EchoBASE EB2642 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2642 EcoGene EG12790 http://www.ecogene.org/geneInfo.php?eg_id=EG12790 EnsemblBacteria AAC76192 http://www.ensemblgenomes.org/id/AAC76192 EnsemblBacteria AAC76192 http://www.ensemblgenomes.org/id/AAC76192 EnsemblBacteria BAE77204 http://www.ensemblgenomes.org/id/BAE77204 EnsemblBacteria BAE77204 http://www.ensemblgenomes.org/id/BAE77204 EnsemblBacteria BAE77204 http://www.ensemblgenomes.org/id/BAE77204 EnsemblBacteria b3158 http://www.ensemblgenomes.org/id/b3158 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GOslim_function GO:0008233 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008233 GeneID 949115 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949115 HOGENOM HOG000276098 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276098&db=HOGENOM6 InParanoid P45527 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45527 IntAct P45527 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45527* IntEnz 3.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.4 InterPro IPR001539 http://www.ebi.ac.uk/interpro/entry/IPR001539 InterPro IPR022998 http://www.ebi.ac.uk/interpro/entry/IPR022998 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01002 http://www.genome.jp/dbget-bin/www_bget?ko01002 KEGG_Gene ecj:JW3127 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3127 KEGG_Gene eco:b3158 http://www.genome.jp/dbget-bin/www_bget?eco:b3158 KEGG_Orthology KO:K08303 http://www.genome.jp/dbget-bin/www_bget?KO:K08303 KEGG_Pathway ko05120 http://www.genome.jp/kegg-bin/show_pathway?ko05120 MINT MINT-1243533 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1243533 OMA NTIIYDH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NTIIYDH PROSITE PS01276 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01276 PSORT swissprot:YHBU_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHBU_ECOLI PSORT-B swissprot:YHBU_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHBU_ECOLI PSORT2 swissprot:YHBU_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHBU_ECOLI Pfam PF01136 http://pfam.xfam.org/family/PF01136 Phobius swissprot:YHBU_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHBU_ECOLI PhylomeDB P45527 http://phylomedb.org/?seqid=P45527 ProteinModelPortal P45527 http://www.proteinmodelportal.org/query/uniprot/P45527 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417627 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417627 RefSeq WP_001311152 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001311152 SMR P45527 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45527 STRING 511145.b3158 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3158&targetmode=cogs STRING COG0826 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0826&targetmode=cogs SUPFAM SSF51391 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51391 UniProtKB YHBU_ECOLI http://www.uniprot.org/uniprot/YHBU_ECOLI UniProtKB-AC P45527 http://www.uniprot.org/uniprot/P45527 charge swissprot:YHBU_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHBU_ECOLI eggNOG COG0826 http://eggnogapi.embl.de/nog_data/html/tree/COG0826 eggNOG ENOG4105CFP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CFP epestfind swissprot:YHBU_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHBU_ECOLI garnier swissprot:YHBU_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHBU_ECOLI helixturnhelix swissprot:YHBU_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHBU_ECOLI hmoment swissprot:YHBU_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHBU_ECOLI iep swissprot:YHBU_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHBU_ECOLI inforesidue swissprot:YHBU_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHBU_ECOLI octanol swissprot:YHBU_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHBU_ECOLI pepcoil swissprot:YHBU_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHBU_ECOLI pepdigest swissprot:YHBU_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHBU_ECOLI pepinfo swissprot:YHBU_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHBU_ECOLI pepnet swissprot:YHBU_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHBU_ECOLI pepstats swissprot:YHBU_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHBU_ECOLI pepwheel swissprot:YHBU_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHBU_ECOLI pepwindow swissprot:YHBU_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHBU_ECOLI sigcleave swissprot:YHBU_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHBU_ECOLI ## Database ID URL or Descriptions # BioGrid 4260142 189 # EcoGene EG13924 ynaI # FUNCTION YNAI_ECOLI Mechanosensitive channel that protects cells against hypoosmotic stress when highly overexpressed. {ECO 0000269|PubMed 22874652}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006811 ion transport; IEA:UniProtKB-KW. # GO_process GO:0055085 transmembrane transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # IntAct P0AEB5 3 # InterPro IPR006685 MscS_channel # InterPro IPR006686 MscS_channel_CS # InterPro IPR010920 LSM_dom # InterPro IPR011014 MscS_channel_TM-2 # InterPro IPR011066 MscC_channel_C # KEGG_Brite ko02000 Transporters # Organism YNAI_ECOLI Escherichia coli (strain K12) # PATRIC 32117936 VBIEscCol129921_1388 # PIR E64882 E64882 # PROSITE PS01246 UPF0003 # Pfam PF00924 MS_channel # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNAI_ECOLI Low conductance mechanosensitive channel YnaI # RefSeq NP_415846 NC_000913.3 # RefSeq WP_000559900 NZ_LN832404.1 # SIMILARITY Belongs to the MscS (TC 1.A.23) family. {ECO 0000305}. # SUBCELLULAR LOCATION YNAI_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 22874652}; Multi- pass membrane protein {ECO 0000269|PubMed 15919996, ECO 0000269|PubMed 22874652}. # SUBUNIT Homoheptamer. {ECO:0000269|PubMed 22874652}. # SUPFAM SSF50182 SSF50182 # SUPFAM SSF82689 SSF82689 # SUPFAM SSF82861 SSF82861 # TCDB 1.A.23.4 the small conductance mechanosensitive ion channel (mscs) family # eggNOG COG0668 LUCA # eggNOG ENOG4105D64 Bacteria BLAST swissprot:YNAI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNAI_ECOLI BioCyc ECOL316407:JW1323-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1323-MONOMER BioCyc EcoCyc:MONOMER0-82 http://biocyc.org/getid?id=EcoCyc:MONOMER0-82 COG COG0668 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0668 DIP DIP-12740N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12740N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.4161/chan.20998 http://dx.doi.org/10.4161/chan.20998 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3683 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3683 EcoGene EG13924 http://www.ecogene.org/geneInfo.php?eg_id=EG13924 EnsemblBacteria AAC74412 http://www.ensemblgenomes.org/id/AAC74412 EnsemblBacteria AAC74412 http://www.ensemblgenomes.org/id/AAC74412 EnsemblBacteria BAA14923 http://www.ensemblgenomes.org/id/BAA14923 EnsemblBacteria BAA14923 http://www.ensemblgenomes.org/id/BAA14923 EnsemblBacteria BAA14923 http://www.ensemblgenomes.org/id/BAA14923 EnsemblBacteria b1330 http://www.ensemblgenomes.org/id/b1330 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006811 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 945898 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945898 HOGENOM HOG000060775 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000060775&db=HOGENOM6 InParanoid P0AEB5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEB5 IntAct P0AEB5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEB5* InterPro IPR006685 http://www.ebi.ac.uk/interpro/entry/IPR006685 InterPro IPR006686 http://www.ebi.ac.uk/interpro/entry/IPR006686 InterPro IPR010920 http://www.ebi.ac.uk/interpro/entry/IPR010920 InterPro IPR011014 http://www.ebi.ac.uk/interpro/entry/IPR011014 InterPro IPR011066 http://www.ebi.ac.uk/interpro/entry/IPR011066 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1323 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1323 KEGG_Gene eco:b1330 http://www.genome.jp/dbget-bin/www_bget?eco:b1330 KEGG_Orthology KO:K16052 http://www.genome.jp/dbget-bin/www_bget?KO:K16052 OMA SRIQNYR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SRIQNYR PROSITE PS01246 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01246 PSORT swissprot:YNAI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNAI_ECOLI PSORT-B swissprot:YNAI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNAI_ECOLI PSORT2 swissprot:YNAI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNAI_ECOLI Pfam PF00924 http://pfam.xfam.org/family/PF00924 Phobius swissprot:YNAI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNAI_ECOLI PhylomeDB P0AEB5 http://phylomedb.org/?seqid=P0AEB5 ProteinModelPortal P0AEB5 http://www.proteinmodelportal.org/query/uniprot/P0AEB5 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22874652 http://www.ncbi.nlm.nih.gov/pubmed/22874652 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415846 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415846 RefSeq WP_000559900 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000559900 SMR P0AEB5 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEB5 STRING 511145.b1330 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1330&targetmode=cogs STRING COG0668 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0668&targetmode=cogs SUPFAM SSF50182 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50182 SUPFAM SSF82689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF82689 SUPFAM SSF82861 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF82861 TCDB 1.A.23.4 http://www.tcdb.org/search/result.php?tc=1.A.23.4 UniProtKB YNAI_ECOLI http://www.uniprot.org/uniprot/YNAI_ECOLI UniProtKB-AC P0AEB5 http://www.uniprot.org/uniprot/P0AEB5 charge swissprot:YNAI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNAI_ECOLI eggNOG COG0668 http://eggnogapi.embl.de/nog_data/html/tree/COG0668 eggNOG ENOG4105D64 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D64 epestfind swissprot:YNAI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNAI_ECOLI garnier swissprot:YNAI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNAI_ECOLI helixturnhelix swissprot:YNAI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNAI_ECOLI hmoment swissprot:YNAI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNAI_ECOLI iep swissprot:YNAI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNAI_ECOLI inforesidue swissprot:YNAI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNAI_ECOLI octanol swissprot:YNAI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNAI_ECOLI pepcoil swissprot:YNAI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNAI_ECOLI pepdigest swissprot:YNAI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNAI_ECOLI pepinfo swissprot:YNAI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNAI_ECOLI pepnet swissprot:YNAI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNAI_ECOLI pepstats swissprot:YNAI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNAI_ECOLI pepwheel swissprot:YNAI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNAI_ECOLI pepwindow swissprot:YNAI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNAI_ECOLI sigcleave swissprot:YNAI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNAI_ECOLI ## Database ID URL or Descriptions # BioGrid 4260990 160 # EcoGene EG13108 ygbN # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0005215 transporter activity; IBA:GO_Central. # GO_function GO:0015128 gluconate transmembrane transporter activity; IEA:InterPro. # GO_process GO:0055085 transmembrane transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0055085 transmembrane transport # InterPro IPR003474 Glcn_transporter # KEGG_Brite ko02000 Transporters # Organism YGBN_ECOLI Escherichia coli (strain K12) # PATRIC 32120884 VBIEscCol129921_2834 # PIR H65054 H65054 # PIRSF PIRSF002746 Gluconate_transporter # Pfam PF02447 GntP_permease # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGBN_ECOLI Inner membrane permease YgbN # RefSeq NP_417220 NC_000913.3 # RefSeq WP_000104441 NZ_LN832404.1 # SIMILARITY Belongs to the GntP permease family. {ECO 0000305}. # SUBCELLULAR LOCATION YGBN_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.8.1:the gluconate h(+) symporter (gntp) family # TIGRFAMs TIGR00791 gntP # eggNOG COG2610 LUCA # eggNOG ENOG4105C6Z Bacteria BLAST swissprot:YGBN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGBN_ECOLI BioCyc ECOL316407:JW2710-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2710-MONOMER BioCyc EcoCyc:B2740-MONOMER http://biocyc.org/getid?id=EcoCyc:B2740-MONOMER COG COG2610 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2610 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EchoBASE EB2911 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2911 EcoGene EG13108 http://www.ecogene.org/geneInfo.php?eg_id=EG13108 EnsemblBacteria AAC75782 http://www.ensemblgenomes.org/id/AAC75782 EnsemblBacteria AAC75782 http://www.ensemblgenomes.org/id/AAC75782 EnsemblBacteria BAE76817 http://www.ensemblgenomes.org/id/BAE76817 EnsemblBacteria BAE76817 http://www.ensemblgenomes.org/id/BAE76817 EnsemblBacteria BAE76817 http://www.ensemblgenomes.org/id/BAE76817 EnsemblBacteria b2740 http://www.ensemblgenomes.org/id/b2740 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_function GO:0015128 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015128 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 947208 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947208 HOGENOM HOG000237114 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000237114&db=HOGENOM6 InParanoid Q46892 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46892 InterPro IPR003474 http://www.ebi.ac.uk/interpro/entry/IPR003474 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2710 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2710 KEGG_Gene eco:b2740 http://www.genome.jp/dbget-bin/www_bget?eco:b2740 KEGG_Orthology KO:K03299 http://www.genome.jp/dbget-bin/www_bget?KO:K03299 OMA GLRTWTV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GLRTWTV PSORT swissprot:YGBN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGBN_ECOLI PSORT-B swissprot:YGBN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGBN_ECOLI PSORT2 swissprot:YGBN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGBN_ECOLI Pfam PF02447 http://pfam.xfam.org/family/PF02447 Phobius swissprot:YGBN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGBN_ECOLI PhylomeDB Q46892 http://phylomedb.org/?seqid=Q46892 ProteinModelPortal Q46892 http://www.proteinmodelportal.org/query/uniprot/Q46892 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417220 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417220 RefSeq WP_000104441 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000104441 STRING 511145.b2740 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2740&targetmode=cogs STRING COG2610 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2610&targetmode=cogs TCDB 2.A.8.1 http://www.tcdb.org/search/result.php?tc=2.A.8.1 TIGRFAMs TIGR00791 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00791 UniProtKB YGBN_ECOLI http://www.uniprot.org/uniprot/YGBN_ECOLI UniProtKB-AC Q46892 http://www.uniprot.org/uniprot/Q46892 charge swissprot:YGBN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGBN_ECOLI eggNOG COG2610 http://eggnogapi.embl.de/nog_data/html/tree/COG2610 eggNOG ENOG4105C6Z http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C6Z epestfind swissprot:YGBN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGBN_ECOLI garnier swissprot:YGBN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGBN_ECOLI helixturnhelix swissprot:YGBN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGBN_ECOLI hmoment swissprot:YGBN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGBN_ECOLI iep swissprot:YGBN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGBN_ECOLI inforesidue swissprot:YGBN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGBN_ECOLI octanol swissprot:YGBN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGBN_ECOLI pepcoil swissprot:YGBN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGBN_ECOLI pepdigest swissprot:YGBN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGBN_ECOLI pepinfo swissprot:YGBN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGBN_ECOLI pepnet swissprot:YGBN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGBN_ECOLI pepstats swissprot:YGBN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGBN_ECOLI pepwheel swissprot:YGBN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGBN_ECOLI pepwindow swissprot:YGBN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGBN_ECOLI sigcleave swissprot:YGBN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGBN_ECOLI ## Database ID URL or Descriptions # BioGrid 4259888 8 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG14317 tfaX # InterPro IPR003458 Phage_T4_Gp38_tail_assem # MISCELLANEOUS TFAX_ECOLI Encoded by the cryptic lambdoid prophage DLP12. # Organism TFAX_ECOLI Escherichia coli (strain K12) # PATRIC 48660335 VBIEscCol107702_0559 # PIR A64789 A64789 # Pfam PF02413 Caudo_TAP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TFAX_ECOLI Putative uncharacterized protein TfaX # SIMILARITY Belongs to the tfa family. {ECO 0000305}. BLAST swissprot:TFAX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TFAX_ECOLI BioCyc ECOL316407:ECK0555-MONOMER http://biocyc.org/getid?id=ECOL316407:ECK0555-MONOMER BioCyc EcoCyc:G6317-MONOMER http://biocyc.org/getid?id=EcoCyc:G6317-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB4064 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4064 EcoGene EG14317 http://www.ecogene.org/geneInfo.php?eg_id=EG14317 EnsemblBacteria BAE76338 http://www.ensemblgenomes.org/id/BAE76338 EnsemblBacteria BAE76338 http://www.ensemblgenomes.org/id/BAE76338 EnsemblBacteria BAE76338 http://www.ensemblgenomes.org/id/BAE76338 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv InterPro IPR003458 http://www.ebi.ac.uk/interpro/entry/IPR003458 KEGG_Gene ecj:JW0552 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0552 PSORT swissprot:TFAX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TFAX_ECOLI PSORT-B swissprot:TFAX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TFAX_ECOLI PSORT2 swissprot:TFAX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TFAX_ECOLI Pfam PF02413 http://pfam.xfam.org/family/PF02413 Phobius swissprot:TFAX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TFAX_ECOLI ProteinModelPortal P77087 http://www.proteinmodelportal.org/query/uniprot/P77087 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 UniProtKB TFAX_ECOLI http://www.uniprot.org/uniprot/TFAX_ECOLI UniProtKB-AC P77087 http://www.uniprot.org/uniprot/P77087 charge swissprot:TFAX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TFAX_ECOLI epestfind swissprot:TFAX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TFAX_ECOLI garnier swissprot:TFAX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TFAX_ECOLI helixturnhelix swissprot:TFAX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TFAX_ECOLI hmoment swissprot:TFAX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TFAX_ECOLI iep swissprot:TFAX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TFAX_ECOLI inforesidue swissprot:TFAX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TFAX_ECOLI octanol swissprot:TFAX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TFAX_ECOLI pepcoil swissprot:TFAX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TFAX_ECOLI pepdigest swissprot:TFAX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TFAX_ECOLI pepinfo swissprot:TFAX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TFAX_ECOLI pepnet swissprot:TFAX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TFAX_ECOLI pepstats swissprot:TFAX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TFAX_ECOLI pepwheel swissprot:TFAX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TFAX_ECOLI pepwindow swissprot:TFAX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TFAX_ECOLI sigcleave swissprot:TFAX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TFAX_ECOLI ## Database ID URL or Descriptions # AltName PA1_ECOLI Detergent-resistant phospholipase A # AltName PA1_ECOLI Outer membrane phospholipase A # AltName PA1_ECOLI Phosphatidylcholine 1-acylhydrolase # BioGrid 4259303 272 # CATALYTIC ACTIVITY PA1_ECOLI Phosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate. # CATALYTIC ACTIVITY PA1_ECOLI Phosphatidylcholine + H(2)O = 2- acylglycerophosphocholine + a carboxylate. # CDD cd00541 OMPLA # COFACTOR PA1_ECOLI Name=Ca(2+); Xref=ChEBI CHEBI 29108; Evidence={ECO 0000269|PubMed 10537112}; Note=Binds 1 Ca(2+) ion per monomer. In the dimeric form the Ca(2+) is bound by different amino acids with binding of each Ca(2+) shared with ligands coming from each monomer (Arg-167 and Ser-172 from 1 monomer, Ser-126 of the other). The Ca(2+) ion may have a role in catalysis. {ECO 0000269|PubMed 10537112}; # ENZYME REGULATION PA1_ECOLI By membrane damage, for example, by phage- induced lysis or temperature shock. The protein is inactive in the monomeric form and active in the dimeric form; calcium is essential for dimer stability. {ECO 0000269|PubMed 10322034, ECO 0000269|PubMed 9013551}. # EcoGene EG10738 pldA # FUNCTION PA1_ECOLI Has broad substrate specificity including hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities. Strong expression leads to outer membrane breakdown and cell death; is dormant in normal growing cells. Required for efficient secretion of bacteriocins. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_component GO:0031230 intrinsic component of cell outer membrane; IDA:UniProtKB. # GO_component GO:0045203 integral component of cell outer membrane; IDA:EcoCyc. # GO_function GO:0004623 phospholipase A2 activity; TAS:UniProtKB. # GO_function GO:0005509 calcium ion binding; IDA:UniProtKB. # GO_function GO:0008970 phosphatidylcholine 1-acylhydrolase activity; TAS:UniProtKB. # GO_function GO:0042803 protein homodimerization activity; IDA:UniProtKB. # GO_function GO:0052739 phosphatidylserine 1-acylhydrolase activity; IEA:UniProtKB-EC. # GO_function GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity; IEA:UniProtKB-EC. # GO_process GO:0016042 lipid catabolic process; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009056 catabolic process # Gene3D 2.40.230.10 -; 1. # IntAct P0A921 12 # InterPro IPR003187 PLipase_A1 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00564 Glycerophospholipid metabolism # KEGG_Pathway ko00565 Ether lipid metabolism # KEGG_Pathway ko00590 Arachidonic acid metabolism # KEGG_Pathway ko00591 Linoleic acid metabolism # KEGG_Pathway ko00592 alpha-Linolenic acid metabolism # Organism PA1_ECOLI Escherichia coli (strain K12) # PATRIC 32123143 VBIEscCol129921_3937 # PDB 1FW2 X-ray; 2.60 A; A=21-289 # PDB 1FW3 X-ray; 2.80 A; A/B=21-289 # PDB 1ILD X-ray; 2.80 A; A=21-289 # PDB 1ILZ X-ray; 2.50 A; A=21-289 # PDB 1IM0 X-ray; 2.98 A; A=21-289 # PDB 1QD5 X-ray; 2.17 A; A=21-289 # PDB 1QD6 X-ray; 2.10 A; A/B=33-45, C/D=50-289 # PIR A22133 PSECA1 # PRINTS PR01486 PHPHLIPASEA1 # Pfam PF02253 PLA1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PA1_ECOLI Phospholipase A1 # RefSeq NP_418265 NC_000913.3 # RefSeq WP_001259700 NZ_LN832404.1 # SIMILARITY Belongs to the phospholipase A1 family. {ECO 0000305}. # SUBCELLULAR LOCATION PA1_ECOLI Cell outer membrane {ECO 0000269|PubMed 6397463}; Multi-pass membrane protein {ECO 0000269|PubMed 6397463}. Note=One of the very few enzymes located there. # SUBUNIT PA1_ECOLI Homodimer; dimerization is reversible, and the dimeric form is the active one. {ECO 0000269|PubMed 10322034, ECO 0000269|PubMed 10537112, ECO 0000269|PubMed 9013551}. # SUPFAM SSF56931 SSF56931 # eggNOG COG2829 LUCA # eggNOG ENOG4105HDD Bacteria BLAST swissprot:PA1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PA1_ECOLI BioCyc ECOL316407:JW3794-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3794-MONOMER BioCyc EcoCyc:MONOMER0-341 http://biocyc.org/getid?id=EcoCyc:MONOMER0-341 BioCyc MetaCyc:MONOMER0-341 http://biocyc.org/getid?id=MetaCyc:MONOMER0-341 COG COG2829 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2829 DOI 10.1006/jmbi.2001.4675 http://dx.doi.org/10.1006/jmbi.2001.4675 DOI 10.1007/BF00430442 http://dx.doi.org/10.1007/BF00430442 DOI 10.1038/401717a0 http://dx.doi.org/10.1038/401717a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.272.6.3179 http://dx.doi.org/10.1074/jbc.272.6.3179 DOI 10.1110/ps.17701 http://dx.doi.org/10.1110/ps.17701 DOI 10.1111/j.1432-1033.1991.tb16008.x http://dx.doi.org/10.1111/j.1432-1033.1991.tb16008.x DOI 10.1111/j.1432-1033.1995.tb20801.x http://dx.doi.org/10.1111/j.1432-1033.1995.tb20801.x DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.1.32 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.1.32 EC_number EC:3.1.1.4 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.1.4 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M30198 http://www.ebi.ac.uk/ena/data/view/M30198 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X02143 http://www.ebi.ac.uk/ena/data/view/X02143 ENZYME 3.1.1.32 http://enzyme.expasy.org/EC/3.1.1.32 ENZYME 3.1.1.4 http://enzyme.expasy.org/EC/3.1.1.4 EchoBASE EB0731 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0731 EcoGene EG10738 http://www.ecogene.org/geneInfo.php?eg_id=EG10738 EnsemblBacteria AAC76824 http://www.ensemblgenomes.org/id/AAC76824 EnsemblBacteria AAC76824 http://www.ensemblgenomes.org/id/AAC76824 EnsemblBacteria BAE77480 http://www.ensemblgenomes.org/id/BAE77480 EnsemblBacteria BAE77480 http://www.ensemblgenomes.org/id/BAE77480 EnsemblBacteria BAE77480 http://www.ensemblgenomes.org/id/BAE77480 EnsemblBacteria b3821 http://www.ensemblgenomes.org/id/b3821 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_component GO:0031230 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031230 GO_component GO:0045203 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045203 GO_function GO:0004623 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004623 GO_function GO:0005509 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005509 GO_function GO:0008970 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008970 GO_function GO:0042803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803 GO_function GO:0052739 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052739 GO_function GO:0052740 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052740 GO_process GO:0016042 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016042 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 2.40.230.10 http://www.cathdb.info/version/latest/superfamily/2.40.230.10 GeneID 948307 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948307 HOGENOM HOG000288150 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000288150&db=HOGENOM6 InParanoid P0A921 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A921 IntAct P0A921 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A921* IntEnz 3.1.1.32 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.1.32 IntEnz 3.1.1.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.1.4 InterPro IPR003187 http://www.ebi.ac.uk/interpro/entry/IPR003187 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3794 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3794 KEGG_Gene eco:b3821 http://www.genome.jp/dbget-bin/www_bget?eco:b3821 KEGG_Orthology KO:K01058 http://www.genome.jp/dbget-bin/www_bget?KO:K01058 KEGG_Pathway ko00564 http://www.genome.jp/kegg-bin/show_pathway?ko00564 KEGG_Pathway ko00565 http://www.genome.jp/kegg-bin/show_pathway?ko00565 KEGG_Pathway ko00590 http://www.genome.jp/kegg-bin/show_pathway?ko00590 KEGG_Pathway ko00591 http://www.genome.jp/kegg-bin/show_pathway?ko00591 KEGG_Pathway ko00592 http://www.genome.jp/kegg-bin/show_pathway?ko00592 KEGG_Reaction rn:R01315 http://www.genome.jp/dbget-bin/www_bget?rn:R01315 KEGG_Reaction rn:R01316 http://www.genome.jp/dbget-bin/www_bget?rn:R01316 KEGG_Reaction rn:R01317 http://www.genome.jp/dbget-bin/www_bget?rn:R01317 KEGG_Reaction rn:R02053 http://www.genome.jp/dbget-bin/www_bget?rn:R02053 KEGG_Reaction rn:R02054 http://www.genome.jp/dbget-bin/www_bget?rn:R02054 KEGG_Reaction rn:R04034 http://www.genome.jp/dbget-bin/www_bget?rn:R04034 KEGG_Reaction rn:R07064 http://www.genome.jp/dbget-bin/www_bget?rn:R07064 KEGG_Reaction rn:R07379 http://www.genome.jp/dbget-bin/www_bget?rn:R07379 KEGG_Reaction rn:R07387 http://www.genome.jp/dbget-bin/www_bget?rn:R07387 KEGG_Reaction rn:R07859 http://www.genome.jp/dbget-bin/www_bget?rn:R07859 KEGG_Reaction rn:R07860 http://www.genome.jp/dbget-bin/www_bget?rn:R07860 OMA VEFGYNH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VEFGYNH PDB 1FW2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1FW2 PDB 1FW3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1FW3 PDB 1ILD http://www.ebi.ac.uk/pdbe-srv/view/entry/1ILD PDB 1ILZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1ILZ PDB 1IM0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1IM0 PDB 1QD5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1QD5 PDB 1QD6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1QD6 PDBsum 1FW2 http://www.ebi.ac.uk/pdbsum/1FW2 PDBsum 1FW3 http://www.ebi.ac.uk/pdbsum/1FW3 PDBsum 1ILD http://www.ebi.ac.uk/pdbsum/1ILD PDBsum 1ILZ http://www.ebi.ac.uk/pdbsum/1ILZ PDBsum 1IM0 http://www.ebi.ac.uk/pdbsum/1IM0 PDBsum 1QD5 http://www.ebi.ac.uk/pdbsum/1QD5 PDBsum 1QD6 http://www.ebi.ac.uk/pdbsum/1QD6 PRINTS PR01486 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01486 PSORT swissprot:PA1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PA1_ECOLI PSORT-B swissprot:PA1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PA1_ECOLI PSORT2 swissprot:PA1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PA1_ECOLI Pfam PF02253 http://pfam.xfam.org/family/PF02253 Phobius swissprot:PA1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PA1_ECOLI PhylomeDB P0A921 http://phylomedb.org/?seqid=P0A921 ProteinModelPortal P0A921 http://www.proteinmodelportal.org/query/uniprot/P0A921 PubMed 10322034 http://www.ncbi.nlm.nih.gov/pubmed/10322034 PubMed 10537112 http://www.ncbi.nlm.nih.gov/pubmed/10537112 PubMed 11371166 http://www.ncbi.nlm.nih.gov/pubmed/11371166 PubMed 11567087 http://www.ncbi.nlm.nih.gov/pubmed/11567087 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2040286 http://www.ncbi.nlm.nih.gov/pubmed/2040286 PubMed 3027506 http://www.ncbi.nlm.nih.gov/pubmed/3027506 PubMed 6383820 http://www.ncbi.nlm.nih.gov/pubmed/6383820 PubMed 6397463 http://www.ncbi.nlm.nih.gov/pubmed/6397463 PubMed 6397464 http://www.ncbi.nlm.nih.gov/pubmed/6397464 PubMed 7556153 http://www.ncbi.nlm.nih.gov/pubmed/7556153 PubMed 8300539 http://www.ncbi.nlm.nih.gov/pubmed/8300539 PubMed 9013551 http://www.ncbi.nlm.nih.gov/pubmed/9013551 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418265 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418265 RefSeq WP_001259700 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001259700 SMR P0A921 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A921 STRING 511145.b3821 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3821&targetmode=cogs STRING COG2829 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2829&targetmode=cogs SUPFAM SSF56931 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56931 UniProtKB PA1_ECOLI http://www.uniprot.org/uniprot/PA1_ECOLI UniProtKB-AC P0A921 http://www.uniprot.org/uniprot/P0A921 charge swissprot:PA1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PA1_ECOLI eggNOG COG2829 http://eggnogapi.embl.de/nog_data/html/tree/COG2829 eggNOG ENOG4105HDD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105HDD epestfind swissprot:PA1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PA1_ECOLI garnier swissprot:PA1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PA1_ECOLI helixturnhelix swissprot:PA1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PA1_ECOLI hmoment swissprot:PA1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PA1_ECOLI iep swissprot:PA1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PA1_ECOLI inforesidue swissprot:PA1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PA1_ECOLI octanol swissprot:PA1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PA1_ECOLI pepcoil swissprot:PA1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PA1_ECOLI pepdigest swissprot:PA1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PA1_ECOLI pepinfo swissprot:PA1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PA1_ECOLI pepnet swissprot:PA1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PA1_ECOLI pepstats swissprot:PA1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PA1_ECOLI pepwheel swissprot:PA1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PA1_ECOLI pepwindow swissprot:PA1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PA1_ECOLI sigcleave swissprot:PA1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PA1_ECOLI ## Database ID URL or Descriptions # BioGrid 4262867 340 # DISRUPTION PHENOTYPE In a minCDE operon disruption (minC-minD- minE), cells divide not only at midpoint but also at their poles, yielding small minicells and long rods. Loss of polar localization of several polar-localized proteins including GroEL-GroES, TnaA and YqjD. {ECO:0000269|PubMed 22380631}. # EcoGene EG10598 minE # FUNCTION MINE_ECOLI Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell. {ECO 0000269|PubMed 22380631}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IPI:IntAct. # GO_process GO:0000918 barrier septum site selection; IDA:EcoCyc. # GO_process GO:0032955 regulation of barrier septum assembly; IGI:EcoliWiki. # GO_process GO:0051302 regulation of cell division; IGI:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0008150 biological_process # Gene3D 3.30.1070.10 -; 1. # HAMAP MF_00262 MinE # INTERACTION MINE_ECOLI Self; NbExp=4; IntAct=EBI-1118020, EBI-1118020; P0AEZ3 minD; NbExp=4; IntAct=EBI-1118020, EBI-554545; # IntAct P0A734 19 # InterPro IPR005527 MinE # KEGG_Brite ko03036 Chromosome # Organism MINE_ECOLI Escherichia coli (strain K12) # PATRIC 32117592 VBIEscCol129921_1218 # PDB 1EV0 NMR; -; A/B=31-88 # PDB 3R9I X-ray; 2.60 A; E/F/G/H=12-31 # PDB 3R9J X-ray; 4.30 A; C/D=12-88 # PIR C31877 CEECTF # Pfam PF03776 MinE # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MINE_ECOLI Cell division topological specificity factor # RefSeq NP_415692 NC_000913.3 # RefSeq WP_001185665 NZ_LN832404.1 # SIMILARITY Belongs to the MinE family. {ECO 0000305}. # SUPFAM SSF55229 SSF55229 # TIGRFAMs TIGR01215 minE # eggNOG COG0851 LUCA # eggNOG ENOG4105VJP Bacteria BLAST swissprot:MINE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MINE_ECOLI BioCyc ECOL316407:JW1163-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1163-MONOMER BioCyc EcoCyc:EG10598-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10598-MONOMER COG COG0851 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0851 DIP DIP-35912N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35912N DOI 10.1016/0092-8674(89)90586-2 http://dx.doi.org/10.1016/0092-8674(89)90586-2 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.2012.08021.x http://dx.doi.org/10.1111/j.1365-2958.2012.08021.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J03153 http://www.ebi.ac.uk/ena/data/view/J03153 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0593 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0593 EcoGene EG10598 http://www.ecogene.org/geneInfo.php?eg_id=EG10598 EnsemblBacteria AAC74258 http://www.ensemblgenomes.org/id/AAC74258 EnsemblBacteria AAC74258 http://www.ensemblgenomes.org/id/AAC74258 EnsemblBacteria BAA36008 http://www.ensemblgenomes.org/id/BAA36008 EnsemblBacteria BAA36008 http://www.ensemblgenomes.org/id/BAA36008 EnsemblBacteria BAA36008 http://www.ensemblgenomes.org/id/BAA36008 EnsemblBacteria b1174 http://www.ensemblgenomes.org/id/b1174 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0000918 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000918 GO_process GO:0032955 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032955 GO_process GO:0051302 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051302 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.30.1070.10 http://www.cathdb.info/version/latest/superfamily/3.30.1070.10 GeneID 945740 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945740 HAMAP MF_00262 http://hamap.expasy.org/unirule/MF_00262 HOGENOM HOG000218362 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218362&db=HOGENOM6 InParanoid P0A734 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A734 IntAct P0A734 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A734* InterPro IPR005527 http://www.ebi.ac.uk/interpro/entry/IPR005527 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene ecj:JW1163 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1163 KEGG_Gene eco:b1174 http://www.genome.jp/dbget-bin/www_bget?eco:b1174 KEGG_Orthology KO:K03608 http://www.genome.jp/dbget-bin/www_bget?KO:K03608 OMA QIVIAHE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QIVIAHE PDB 1EV0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1EV0 PDB 3R9I http://www.ebi.ac.uk/pdbe-srv/view/entry/3R9I PDB 3R9J http://www.ebi.ac.uk/pdbe-srv/view/entry/3R9J PDBsum 1EV0 http://www.ebi.ac.uk/pdbsum/1EV0 PDBsum 3R9I http://www.ebi.ac.uk/pdbsum/3R9I PDBsum 3R9J http://www.ebi.ac.uk/pdbsum/3R9J PSORT swissprot:MINE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MINE_ECOLI PSORT-B swissprot:MINE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MINE_ECOLI PSORT2 swissprot:MINE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MINE_ECOLI Pfam PF03776 http://pfam.xfam.org/family/PF03776 Phobius swissprot:MINE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MINE_ECOLI PhylomeDB P0A734 http://phylomedb.org/?seqid=P0A734 ProteinModelPortal P0A734 http://www.proteinmodelportal.org/query/uniprot/P0A734 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22380631 http://www.ncbi.nlm.nih.gov/pubmed/22380631 PubMed 2645057 http://www.ncbi.nlm.nih.gov/pubmed/2645057 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415692 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415692 RefSeq WP_001185665 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001185665 SMR P0A734 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A734 STRING 511145.b1174 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1174&targetmode=cogs STRING COG0851 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0851&targetmode=cogs SUPFAM SSF55229 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55229 TIGRFAMs TIGR01215 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01215 UniProtKB MINE_ECOLI http://www.uniprot.org/uniprot/MINE_ECOLI UniProtKB-AC P0A734 http://www.uniprot.org/uniprot/P0A734 charge swissprot:MINE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MINE_ECOLI eggNOG COG0851 http://eggnogapi.embl.de/nog_data/html/tree/COG0851 eggNOG ENOG4105VJP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VJP epestfind swissprot:MINE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MINE_ECOLI garnier swissprot:MINE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MINE_ECOLI helixturnhelix swissprot:MINE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MINE_ECOLI hmoment swissprot:MINE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MINE_ECOLI iep swissprot:MINE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MINE_ECOLI inforesidue swissprot:MINE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MINE_ECOLI octanol swissprot:MINE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MINE_ECOLI pepcoil swissprot:MINE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MINE_ECOLI pepdigest swissprot:MINE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MINE_ECOLI pepinfo swissprot:MINE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MINE_ECOLI pepnet swissprot:MINE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MINE_ECOLI pepstats swissprot:MINE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MINE_ECOLI pepwheel swissprot:MINE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MINE_ECOLI pepwindow swissprot:MINE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MINE_ECOLI sigcleave swissprot:MINE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MINE_ECOLI ## Database ID URL or Descriptions # BioGrid 4261682 11 # EcoGene EG13222 yaeP # HAMAP MF_01064 UPF0253 # InterPro IPR009624 UPF0253 # Organism YAEP_ECOLI Escherichia coli (strain K12) # PATRIC 32115491 VBIEscCol129921_0197 # Pfam PF06786 UPF0253 # ProDom PD054643 UPF0253 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAEP_ECOLI UPF0253 protein YaeP # RefSeq WP_000417058 NZ_LN832404.1 # RefSeq YP_026160 NC_000913.3 # SIMILARITY Belongs to the UPF0253 family. {ECO 0000305}. # eggNOG ENOG4105W1I Bacteria # eggNOG ENOG4112271 LUCA BLAST swissprot:YAEP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAEP_ECOLI BioCyc ECOL316407:JW0185-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0185-MONOMER BioCyc EcoCyc:MONOMER0-741 http://biocyc.org/getid?id=EcoCyc:MONOMER0-741 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1998.00981.x http://dx.doi.org/10.1046/j.1365-2958.1998.00981.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D49445 http://www.ebi.ac.uk/ena/data/view/D49445 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL Z50870 http://www.ebi.ac.uk/ena/data/view/Z50870 EchoBASE EB3013 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3013 EcoGene EG13222 http://www.ecogene.org/geneInfo.php?eg_id=EG13222 EnsemblBacteria AAT48124 http://www.ensemblgenomes.org/id/AAT48124 EnsemblBacteria AAT48124 http://www.ensemblgenomes.org/id/AAT48124 EnsemblBacteria BAA77865 http://www.ensemblgenomes.org/id/BAA77865 EnsemblBacteria BAA77865 http://www.ensemblgenomes.org/id/BAA77865 EnsemblBacteria BAA77865 http://www.ensemblgenomes.org/id/BAA77865 EnsemblBacteria b4406 http://www.ensemblgenomes.org/id/b4406 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1450233 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1450233 HAMAP MF_01064 http://hamap.expasy.org/unirule/MF_01064 HOGENOM HOG000218315 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218315&db=HOGENOM6 IntAct P0A8K5 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8K5* InterPro IPR009624 http://www.ebi.ac.uk/interpro/entry/IPR009624 KEGG_Gene ecj:JW0185 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0185 KEGG_Gene eco:b4406 http://www.genome.jp/dbget-bin/www_bget?eco:b4406 OMA YIPDALG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YIPDALG PSORT swissprot:YAEP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAEP_ECOLI PSORT-B swissprot:YAEP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAEP_ECOLI PSORT2 swissprot:YAEP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAEP_ECOLI Pfam PF06786 http://pfam.xfam.org/family/PF06786 Phobius swissprot:YAEP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAEP_ECOLI ProteinModelPortal P0A8K5 http://www.proteinmodelportal.org/query/uniprot/P0A8K5 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9723924 http://www.ncbi.nlm.nih.gov/pubmed/9723924 RefSeq WP_000417058 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000417058 RefSeq YP_026160 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026160 STRING 511145.b4406 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4406&targetmode=cogs UniProtKB YAEP_ECOLI http://www.uniprot.org/uniprot/YAEP_ECOLI UniProtKB-AC P0A8K5 http://www.uniprot.org/uniprot/P0A8K5 charge swissprot:YAEP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAEP_ECOLI eggNOG ENOG4105W1I http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105W1I eggNOG ENOG4112271 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4112271 epestfind swissprot:YAEP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAEP_ECOLI garnier swissprot:YAEP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAEP_ECOLI helixturnhelix swissprot:YAEP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAEP_ECOLI hmoment swissprot:YAEP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAEP_ECOLI iep swissprot:YAEP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAEP_ECOLI inforesidue swissprot:YAEP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAEP_ECOLI octanol swissprot:YAEP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAEP_ECOLI pepcoil swissprot:YAEP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAEP_ECOLI pepdigest swissprot:YAEP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAEP_ECOLI pepinfo swissprot:YAEP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAEP_ECOLI pepnet swissprot:YAEP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAEP_ECOLI pepstats swissprot:YAEP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAEP_ECOLI pepwheel swissprot:YAEP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAEP_ECOLI pepwindow swissprot:YAEP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAEP_ECOLI sigcleave swissprot:YAEP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAEP_ECOLI ## Database ID URL or Descriptions # BioGrid 4261728 144 # COFACTOR RSXC_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000255|HAMAP-Rule MF_00461}; Note=Binds 2 [4Fe-4S] clusters per subunit. {ECO 0000255|HAMAP- Rule MF_00461}; # EcoGene EG13935 rsxC # FUNCTION RSXC_ECOLI Part of a membrane complex involved in electron transport. Required to maintain the reduced state of SoxR. {ECO 0000255|HAMAP-Rule MF_00461, ECO 0000269|PubMed 12773378}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_function GO:0009055 electron carrier activity; IEA:InterPro. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051287 NAD binding; IBA:GO_Central. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IBA:GO_Central. # GO_process GO:0009060 aerobic respiration; IBA:GO_Central. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # HAMAP MF_00461 RsxC_RnfC # IntAct P77611 4 # InterPro IPR009051 Helical_ferredxn # InterPro IPR010208 Elect_transpt_RnfC/RsxC # InterPro IPR011538 Nuo51_FMN-bd # InterPro IPR017896 4Fe4S_Fe-S-bd # InterPro IPR017900 4Fe4S_Fe_S_CS # InterPro IPR019554 Soluble_ligand-bd # InterPro IPR026902 RnfC_N # Organism RSXC_ECOLI Escherichia coli (strain K12) # PATRIC 32118560 VBIEscCol129921_1700 # PIR G64919 G64919 # PROSITE PS00198 4FE4S_FER_1; 2 # PROSITE PS51379 4FE4S_FER_2; 2 # Pfam PF01512 Complex1_51K # Pfam PF10531 SLBB # Pfam PF12838 Fer4_7 # Pfam PF13375 RnfC_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Electron transport complex subunit RsxC {ECO:0000255|HAMAP-Rule MF_00461} # RefSeq NP_416146 NC_000913.3 # RefSeq WP_000915778 NZ_LN832404.1 # SIMILARITY Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily. {ECO:0000255|HAMAP-Rule MF_00461}. # SIMILARITY Contains 2 4Fe-4S ferredoxin-type domains. {ECO:0000255|HAMAP-Rule MF_00461}. # SUBCELLULAR LOCATION RSXC_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_00461}; Peripheral membrane protein {ECO 0000255|HAMAP- Rule MF_00461}. # SUBUNIT Composed of six subunits; RsxA, RsxB, RsxC, RsxD, RsxE and RsxG. {ECO:0000305|PubMed 12773378}. # SUPFAM SSF46548 SSF46548 # TCDB 3.D.6.1:the putative ion (h(+) or na(+))-translocating nadh ferredoxin oxidoreductase (nfo or rnf) family # TIGRFAMs TIGR01945 rnfC # eggNOG COG4656 LUCA # eggNOG ENOG4107QTR Bacteria BLAST swissprot:RSXC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RSXC_ECOLI BioCyc ECOL316407:JW1621-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1621-MONOMER BioCyc EcoCyc:G6873-MONOMER http://biocyc.org/getid?id=EcoCyc:G6873-MONOMER COG COG1726 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1726 DIP DIP-28084N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-28084N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/emboj/cdg252 http://dx.doi.org/10.1093/emboj/cdg252 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3694 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3694 EcoGene EG13935 http://www.ecogene.org/geneInfo.php?eg_id=EG13935 EnsemblBacteria AAC74701 http://www.ensemblgenomes.org/id/AAC74701 EnsemblBacteria AAC74701 http://www.ensemblgenomes.org/id/AAC74701 EnsemblBacteria BAA15384 http://www.ensemblgenomes.org/id/BAA15384 EnsemblBacteria BAA15384 http://www.ensemblgenomes.org/id/BAA15384 EnsemblBacteria BAA15384 http://www.ensemblgenomes.org/id/BAA15384 EnsemblBacteria b1629 http://www.ensemblgenomes.org/id/b1629 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051287 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0009060 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009060 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GeneID 946137 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946137 HAMAP MF_00461 http://hamap.expasy.org/unirule/MF_00461 HOGENOM HOG000279299 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000279299&db=HOGENOM6 InParanoid P77611 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77611 IntAct P77611 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77611* InterPro IPR009051 http://www.ebi.ac.uk/interpro/entry/IPR009051 InterPro IPR010208 http://www.ebi.ac.uk/interpro/entry/IPR010208 InterPro IPR011538 http://www.ebi.ac.uk/interpro/entry/IPR011538 InterPro IPR017896 http://www.ebi.ac.uk/interpro/entry/IPR017896 InterPro IPR017900 http://www.ebi.ac.uk/interpro/entry/IPR017900 InterPro IPR019554 http://www.ebi.ac.uk/interpro/entry/IPR019554 InterPro IPR026902 http://www.ebi.ac.uk/interpro/entry/IPR026902 KEGG_Gene ecj:JW1621 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1621 KEGG_Gene eco:b1629 http://www.genome.jp/dbget-bin/www_bget?eco:b1629 KEGG_Orthology KO:K03615 http://www.genome.jp/dbget-bin/www_bget?KO:K03615 OMA QNREESQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QNREESQ PROSITE PS00198 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00198 PROSITE PS51379 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51379 PSORT swissprot:RSXC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RSXC_ECOLI PSORT-B swissprot:RSXC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RSXC_ECOLI PSORT2 swissprot:RSXC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RSXC_ECOLI Pfam PF01512 http://pfam.xfam.org/family/PF01512 Pfam PF10531 http://pfam.xfam.org/family/PF10531 Pfam PF12838 http://pfam.xfam.org/family/PF12838 Pfam PF13375 http://pfam.xfam.org/family/PF13375 Phobius swissprot:RSXC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RSXC_ECOLI PhylomeDB P77611 http://phylomedb.org/?seqid=P77611 ProteinModelPortal P77611 http://www.proteinmodelportal.org/query/uniprot/P77611 PubMed 12773378 http://www.ncbi.nlm.nih.gov/pubmed/12773378 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416146 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416146 RefSeq WP_000915778 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000915778 STRING 511145.b1629 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1629&targetmode=cogs STRING COG1726 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1726&targetmode=cogs SUPFAM SSF46548 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46548 TCDB 3.D.6.1 http://www.tcdb.org/search/result.php?tc=3.D.6.1 TIGRFAMs TIGR01945 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01945 UniProtKB RSXC_ECOLI http://www.uniprot.org/uniprot/RSXC_ECOLI UniProtKB-AC P77611 http://www.uniprot.org/uniprot/P77611 charge swissprot:RSXC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RSXC_ECOLI eggNOG COG4656 http://eggnogapi.embl.de/nog_data/html/tree/COG4656 eggNOG ENOG4107QTR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QTR epestfind swissprot:RSXC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RSXC_ECOLI garnier swissprot:RSXC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RSXC_ECOLI helixturnhelix swissprot:RSXC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RSXC_ECOLI hmoment swissprot:RSXC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RSXC_ECOLI iep swissprot:RSXC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RSXC_ECOLI inforesidue swissprot:RSXC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RSXC_ECOLI octanol swissprot:RSXC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RSXC_ECOLI pepcoil swissprot:RSXC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RSXC_ECOLI pepdigest swissprot:RSXC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RSXC_ECOLI pepinfo swissprot:RSXC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RSXC_ECOLI pepnet swissprot:RSXC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RSXC_ECOLI pepstats swissprot:RSXC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RSXC_ECOLI pepwheel swissprot:RSXC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RSXC_ECOLI pepwindow swissprot:RSXC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RSXC_ECOLI sigcleave swissprot:RSXC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RSXC_ECOLI ## Database ID URL or Descriptions # BioGrid 4259595 220 # CAZy GT9 Glycosyltransferase Family 9 # EcoGene EG11341 rfaQ # FUNCTION RFAQ_ECOLI Catalyzes heptose transfer to the lipopolysaccharide core. It transfers a heptose, called heptose(III), to the heptose(II) of the inner core (By similarity). {ECO 0000250}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0008713 ADP-heptose-lipopolysaccharide heptosyltransferase activity; IBA:GO_Central. # GO_function GO:0071967 lipopolysaccharide core heptosyltransferase activity; IDA:EcoCyc. # GO_process GO:0009244 lipopolysaccharide core region biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # IntAct P25742 2 # InterPro IPR002201 Glyco_trans_9 # InterPro IPR011916 LipoPS_heptosylTferase-III # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01003 Glycosyltransferases # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # KEGG_Pathway ko00540 Lipopolysaccharide biosynthesis # Organism RFAQ_ECOLI Escherichia coli (strain K12) # PATHWAY RFAQ_ECOLI Bacterial outer membrane biogenesis; LPS core biosynthesis. # PATRIC 32122751 VBIEscCol129921_3752 # PIR S27560 S27560 # Pfam PF01075 Glyco_transf_9 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RFAQ_ECOLI Lipopolysaccharide core heptosyltransferase RfaQ # RefSeq NP_418089 NC_000913.3 # RefSeq WP_001268851 NZ_LN832404.1 # SIMILARITY Belongs to the glycosyltransferase 9 family. {ECO 0000305}. # TIGRFAMs TIGR02201 heptsyl_trn_III # eggNOG COG0859 LUCA # eggNOG ENOG4105DKP Bacteria BLAST swissprot:RFAQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RFAQ_ECOLI BioCyc ECOL316407:JW3607-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3607-MONOMER BioCyc EcoCyc:EG11341-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11341-MONOMER BioCyc MetaCyc:EG11341-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11341-MONOMER COG COG0859 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0859 DIP DIP-10675N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10675N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:2.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M80599 http://www.ebi.ac.uk/ena/data/view/M80599 EMBL M86305 http://www.ebi.ac.uk/ena/data/view/M86305 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.-.-.- http://enzyme.expasy.org/EC/2.-.-.- EchoBASE EB1317 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1317 EcoGene EG11341 http://www.ecogene.org/geneInfo.php?eg_id=EG11341 EnsemblBacteria AAC76656 http://www.ensemblgenomes.org/id/AAC76656 EnsemblBacteria AAC76656 http://www.ensemblgenomes.org/id/AAC76656 EnsemblBacteria BAE77660 http://www.ensemblgenomes.org/id/BAE77660 EnsemblBacteria BAE77660 http://www.ensemblgenomes.org/id/BAE77660 EnsemblBacteria BAE77660 http://www.ensemblgenomes.org/id/BAE77660 EnsemblBacteria b3632 http://www.ensemblgenomes.org/id/b3632 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008713 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008713 GO_function GO:0071967 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071967 GO_process GO:0009244 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009244 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 948155 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948155 HOGENOM HOG000010798 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000010798&db=HOGENOM6 InParanoid P25742 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P25742 IntAct P25742 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P25742* IntEnz 2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2 InterPro IPR002201 http://www.ebi.ac.uk/interpro/entry/IPR002201 InterPro IPR011916 http://www.ebi.ac.uk/interpro/entry/IPR011916 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01003 http://www.genome.jp/dbget-bin/www_bget?ko01003 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Gene ecj:JW3607 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3607 KEGG_Gene eco:b3632 http://www.genome.jp/dbget-bin/www_bget?eco:b3632 KEGG_Orthology KO:K02849 http://www.genome.jp/dbget-bin/www_bget?KO:K02849 KEGG_Pathway ko00540 http://www.genome.jp/kegg-bin/show_pathway?ko00540 MINT MINT-1275410 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1275410 OMA SMPMHLA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SMPMHLA PSORT swissprot:RFAQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RFAQ_ECOLI PSORT-B swissprot:RFAQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RFAQ_ECOLI PSORT2 swissprot:RFAQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RFAQ_ECOLI Pfam PF01075 http://pfam.xfam.org/family/PF01075 Phobius swissprot:RFAQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RFAQ_ECOLI PhylomeDB P25742 http://phylomedb.org/?seqid=P25742 ProteinModelPortal P25742 http://www.proteinmodelportal.org/query/uniprot/P25742 PubMed 1447141 http://www.ncbi.nlm.nih.gov/pubmed/1447141 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1732225 http://www.ncbi.nlm.nih.gov/pubmed/1732225 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418089 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418089 RefSeq WP_001268851 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001268851 STRING 511145.b3632 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3632&targetmode=cogs STRING COG0859 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0859&targetmode=cogs TIGRFAMs TIGR02201 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02201 UniProtKB RFAQ_ECOLI http://www.uniprot.org/uniprot/RFAQ_ECOLI UniProtKB-AC P25742 http://www.uniprot.org/uniprot/P25742 charge swissprot:RFAQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RFAQ_ECOLI eggNOG COG0859 http://eggnogapi.embl.de/nog_data/html/tree/COG0859 eggNOG ENOG4105DKP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DKP epestfind swissprot:RFAQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RFAQ_ECOLI garnier swissprot:RFAQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RFAQ_ECOLI helixturnhelix swissprot:RFAQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RFAQ_ECOLI hmoment swissprot:RFAQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RFAQ_ECOLI iep swissprot:RFAQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RFAQ_ECOLI inforesidue swissprot:RFAQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RFAQ_ECOLI octanol swissprot:RFAQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RFAQ_ECOLI pepcoil swissprot:RFAQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RFAQ_ECOLI pepdigest swissprot:RFAQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RFAQ_ECOLI pepinfo swissprot:RFAQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RFAQ_ECOLI pepnet swissprot:RFAQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RFAQ_ECOLI pepstats swissprot:RFAQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RFAQ_ECOLI pepwheel swissprot:RFAQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RFAQ_ECOLI pepwindow swissprot:RFAQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RFAQ_ECOLI sigcleave swissprot:RFAQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RFAQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4262946 195 # EcoGene EG11354 emrA # FUNCTION EMRA_ECOLI Part of the tripartite efflux system EmrAB-TolC, which confers resistance to antibiotics such as CCCP, FCCP, 2,4- dinitrophenol and nalidixic acid. EmrA is a drug-binding protein that provides a physical link between EmrB and TolC. {ECO 0000269|PubMed 12482849, ECO 0000269|PubMed 1409590}. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_component GO:0031226 intrinsic component of plasma membrane; IMP:EcoliWiki. # GO_component GO:0031237 intrinsic component of periplasmic side of plasma membrane; IDA:EcoCyc. # GO_function GO:0015238 drug transmembrane transporter activity; IEA:InterPro. # GO_process GO:0046677 response to antibiotic; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0008150 biological_process # IntAct P27303 2 # InterPro IPR005694 Emr # InterPro IPR006143 RND_pump_MFP # InterPro IPR032317 HlyD_D23 # KEGG_Brite ko02000 Transporters # Organism EMRA_ECOLI Escherichia coli (strain K12) # PATRIC 32120764 VBIEscCol129921_2779 # PIR F65048 F65048 # Pfam PF00529 HlyD # Pfam PF16576 HlyD_D23 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName EMRA_ECOLI Multidrug export protein EmrA # RefSeq NP_417170 NC_000913.3 # RefSeq WP_001326681 NZ_LN832404.1 # SIMILARITY Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. {ECO 0000305}. # SUBCELLULAR LOCATION EMRA_ECOLI Cell inner membrane {ECO 0000269|PubMed 12482849, ECO 0000269|PubMed 1409590}; Single- pass membrane protein {ECO 0000269|PubMed 12482849, ECO 0000269|PubMed 1409590}; Periplasmic side {ECO 0000269|PubMed 12482849, ECO 0000269|PubMed 1409590}. # SUBUNIT EMRA_ECOLI Homodimer and homotrimer. Part of the tripartite efflux system EmrAB-TolC, which is composed of an inner membrane transporter, EmrB, a periplasmic membrane fusion protein, EmrA, and an outer membrane component, TolC. The complex forms a large protein conduit and can translocate molecules across both the inner and outer membranes. Interacts with EmrB. EmrAB complex forms a dimer in vitro. {ECO 0000269|PubMed 12482849, ECO 0000269|PubMed 19171121, ECO 0000269|PubMed 19805313}. # TCDB 8.A.1.1 the membrane fusion protein (mfp) family # TIGRFAMs TIGR00998 8a0101 # eggNOG COG1566 LUCA # eggNOG ENOG4105CW7 Bacteria BLAST swissprot:EMRA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EMRA_ECOLI BioCyc ECOL316407:JW2660-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2660-MONOMER BioCyc EcoCyc:EG11354-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11354-MONOMER COG COG1566 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1566 DIP DIP-9502N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9502N DOI 10.1016/0968-0004(94)90204-6 http://dx.doi.org/10.1016/0968-0004(94)90204-6 DOI 10.1016/j.bbrc.2009.01.081 http://dx.doi.org/10.1016/j.bbrc.2009.01.081 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0906601106 http://dx.doi.org/10.1073/pnas.0906601106 DOI 10.1073/pnas.89.19.8938 http://dx.doi.org/10.1073/pnas.89.19.8938 DOI 10.1074/jbc.M209457200 http://dx.doi.org/10.1074/jbc.M209457200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M86657 http://www.ebi.ac.uk/ena/data/view/M86657 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1329 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1329 EcoGene EG11354 http://www.ecogene.org/geneInfo.php?eg_id=EG11354 EnsemblBacteria AAC75732 http://www.ensemblgenomes.org/id/AAC75732 EnsemblBacteria AAC75732 http://www.ensemblgenomes.org/id/AAC75732 EnsemblBacteria BAA16547 http://www.ensemblgenomes.org/id/BAA16547 EnsemblBacteria BAA16547 http://www.ensemblgenomes.org/id/BAA16547 EnsemblBacteria BAA16547 http://www.ensemblgenomes.org/id/BAA16547 EnsemblBacteria b2685 http://www.ensemblgenomes.org/id/b2685 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0031226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031226 GO_component GO:0031237 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031237 GO_function GO:0015238 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015238 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 947166 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947166 HOGENOM HOG000112072 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000112072&db=HOGENOM6 InParanoid P27303 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P27303 IntAct P27303 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P27303* InterPro IPR005694 http://www.ebi.ac.uk/interpro/entry/IPR005694 InterPro IPR006143 http://www.ebi.ac.uk/interpro/entry/IPR006143 InterPro IPR032317 http://www.ebi.ac.uk/interpro/entry/IPR032317 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2660 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2660 KEGG_Gene eco:b2685 http://www.genome.jp/dbget-bin/www_bget?eco:b2685 KEGG_Orthology KO:K03543 http://www.genome.jp/dbget-bin/www_bget?KO:K03543 OMA RQLMINS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RQLMINS PSORT swissprot:EMRA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EMRA_ECOLI PSORT-B swissprot:EMRA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EMRA_ECOLI PSORT2 swissprot:EMRA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EMRA_ECOLI Pfam PF00529 http://pfam.xfam.org/family/PF00529 Pfam PF16576 http://pfam.xfam.org/family/PF16576 Phobius swissprot:EMRA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EMRA_ECOLI PhylomeDB P27303 http://phylomedb.org/?seqid=P27303 ProteinModelPortal P27303 http://www.proteinmodelportal.org/query/uniprot/P27303 PubMed 12482849 http://www.ncbi.nlm.nih.gov/pubmed/12482849 PubMed 1409590 http://www.ncbi.nlm.nih.gov/pubmed/1409590 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19171121 http://www.ncbi.nlm.nih.gov/pubmed/19171121 PubMed 19805313 http://www.ncbi.nlm.nih.gov/pubmed/19805313 PubMed 8203018 http://www.ncbi.nlm.nih.gov/pubmed/8203018 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417170 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417170 RefSeq WP_001326681 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001326681 SMR P27303 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P27303 STRING 511145.b2685 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2685&targetmode=cogs STRING COG1566 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1566&targetmode=cogs TCDB 8.A.1.1 http://www.tcdb.org/search/result.php?tc=8.A.1.1 TIGRFAMs TIGR00998 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00998 UniProtKB EMRA_ECOLI http://www.uniprot.org/uniprot/EMRA_ECOLI UniProtKB-AC P27303 http://www.uniprot.org/uniprot/P27303 charge swissprot:EMRA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EMRA_ECOLI eggNOG COG1566 http://eggnogapi.embl.de/nog_data/html/tree/COG1566 eggNOG ENOG4105CW7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CW7 epestfind swissprot:EMRA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EMRA_ECOLI garnier swissprot:EMRA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EMRA_ECOLI helixturnhelix swissprot:EMRA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EMRA_ECOLI hmoment swissprot:EMRA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EMRA_ECOLI iep swissprot:EMRA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EMRA_ECOLI inforesidue swissprot:EMRA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EMRA_ECOLI octanol swissprot:EMRA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EMRA_ECOLI pepcoil swissprot:EMRA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EMRA_ECOLI pepdigest swissprot:EMRA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EMRA_ECOLI pepinfo swissprot:EMRA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EMRA_ECOLI pepnet swissprot:EMRA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EMRA_ECOLI pepstats swissprot:EMRA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EMRA_ECOLI pepwheel swissprot:EMRA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EMRA_ECOLI pepwindow swissprot:EMRA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EMRA_ECOLI sigcleave swissprot:EMRA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EMRA_ECOLI ## Database ID URL or Descriptions # AltName (2S,3S)-2-methylcitrate dehydratase {ECO:0000305|PubMed 12473114} # AltName Aconitate hydratase {ECO:0000303|PubMed 11782506} # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=0.44 mM for (2S,3S)-2-methylcitrate {ECO 0000269|PubMed:12473114}; # BRENDA 4.2.1.79 2026 # CATALYTIC ACTIVITY PRPD_ECOLI (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3-tricarboxylate + H(2)O. {ECO 0000269|PubMed 11782506, ECO 0000269|PubMed 12473114}. # CATALYTIC ACTIVITY PRPD_ECOLI Citrate = isocitrate. {ECO 0000269|PubMed 11782506, ECO 0000269|PubMed 12473114}. # DISRUPTION PHENOTYPE Cells lacking this gene abolished the residual aconitase activity of an AcnAB-null strain. {ECO:0000269|PubMed 11782506}. # EcoGene EG13603 prpD # FUNCTION PRPD_ECOLI Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the stereospecific dehydration of (2S,3S)-2- methylcitrate (2-MC) to yield the cis isomer of 2-methyl- aconitate. It is also able to catalyze the dehydration of citrate and the hydration of cis-aconitate at a lower rate. Due to its broad substrate specificity, it seems to be responsible for the residual aconitase activity of the acnAB-null mutant. {ECO 0000269|PubMed 11782506, ECO 0000269|PubMed 12473114}. # GO_function GO:0003994 aconitate hydratase activity; IEA:UniProtKB-EC. # GO_function GO:0047547 2-methylcitrate dehydratase activity; IDA:EcoCyc. # GO_function GO:0051537 2 iron, 2 sulfur cluster binding; IDA:UniProtKB. # GO_process GO:0006099 tricarboxylic acid cycle; IEA:UniProtKB-UniPathway. # GO_process GO:0019629 propionate catabolic process, 2-methylcitrate cycle; IEA:InterPro. # GO_process GO:0019679 propionate metabolic process, methylcitrate cycle; IDA:EcoliWiki. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # INDUCTION PRPD_ECOLI By propionate, but not acetate or glucose. Expression of prpBCDE operon is regulated by PrpR, CRP and a variety of sugars such as arabinose, galactose, glucose mannose and xylose. {ECO 0000269|PubMed 12473114, ECO 0000269|PubMed 15805526, ECO 0000269|PubMed 22579471}. # IntAct P77243 4 # InterPro IPR005656 MmgE_PrpD # InterPro IPR012705 2Me_IsoCit_deHydtase_PrpD # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00640 Propanoate metabolism # MISCELLANEOUS PrpD catalyzes an unusual syn elimination, whereas the addition of water by AcnB to cis-2-methylaconitate occurs in the usual anti manner. {ECO:0000269|PubMed 12473114}. # Organism PRPD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR16943 PTHR16943 # PATHWAY Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2. {ECO 0000305|PubMed:12473114}. # PATHWAY Organic acid metabolism; propanoate degradation. {ECO:0000305|PubMed 12473114}. # PATRIC 32115799 VBIEscCol129921_0341 # PDB 1SZQ X-ray; 2.70 A; A/B=1-483 # PIR F64760 F64760 # Pfam PF03972 MmgE_PrpD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName 2-methylcitrate dehydratase {ECO:0000303|PubMed 11782506} # RefSeq NP_414868 NC_000913.3 # RefSeq WP_001275859 NZ_LN832404.1 # SIMILARITY Belongs to the PrpD family. {ECO 0000305}. # SUBUNIT Monomer. {ECO:0000269|PubMed 11782506, ECO:0000269|Ref.8}. # SUPFAM SSF103378 SSF103378 # TIGRFAMs TIGR02330 prpD # UniPathway UPA00223 UER00718 # eggNOG COG2079 LUCA # eggNOG ENOG4105DXD Bacteria BLAST swissprot:PRPD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PRPD_ECOLI BioCyc ECOL316407:JW0325-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0325-MONOMER BioCyc EcoCyc:G6199-MONOMER http://biocyc.org/getid?id=EcoCyc:G6199-MONOMER BioCyc MetaCyc:G6199-MONOMER http://biocyc.org/getid?id=MetaCyc:G6199-MONOMER COG COG2079 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2079 DIP DIP-10580N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10580N DOI 10.1016/j.gene.2012.04.074 http://dx.doi.org/10.1016/j.gene.2012.04.074 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1432-1033.2002.03336.x http://dx.doi.org/10.1046/j.1432-1033.2002.03336.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.187.8.2793-2800.2005 http://dx.doi.org/10.1128/JB.187.8.2793-2800.2005 EC_number EC:4.2.1.3 {ECO:0000269|PubMed:11782506, ECO:0000269|PubMed:12473114} http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.3 {ECO:0000269|PubMed:11782506, ECO:0000269|PubMed:12473114} EC_number EC:4.2.1.79 {ECO:0000269|PubMed:11782506, ECO:0000269|PubMed:12473114} http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.79 {ECO:0000269|PubMed:11782506, ECO:0000269|PubMed:12473114} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 ENZYME 4.2.1.3 {ECO:0000269|PubMed:11782506, ECO:0000269|PubMed:12473114} http://enzyme.expasy.org/EC/4.2.1.3 {ECO:0000269|PubMed:11782506, ECO:0000269|PubMed:12473114} ENZYME 4.2.1.79 {ECO:0000269|PubMed:11782506, ECO:0000269|PubMed:12473114} http://enzyme.expasy.org/EC/4.2.1.79 {ECO:0000269|PubMed:11782506, ECO:0000269|PubMed:12473114} EchoBASE EB3371 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3371 EcoGene EG13603 http://www.ecogene.org/geneInfo.php?eg_id=EG13603 EnsemblBacteria AAC73437 http://www.ensemblgenomes.org/id/AAC73437 EnsemblBacteria AAC73437 http://www.ensemblgenomes.org/id/AAC73437 EnsemblBacteria BAE76116 http://www.ensemblgenomes.org/id/BAE76116 EnsemblBacteria BAE76116 http://www.ensemblgenomes.org/id/BAE76116 EnsemblBacteria BAE76116 http://www.ensemblgenomes.org/id/BAE76116 EnsemblBacteria b0334 http://www.ensemblgenomes.org/id/b0334 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003994 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003994 GO_function GO:0047547 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047547 GO_function GO:0051537 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051537 GO_process GO:0006099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006099 GO_process GO:0019629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019629 GO_process GO:0019679 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019679 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 945931 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945931 HOGENOM HOG000159916 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000159916&db=HOGENOM6 InParanoid P77243 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77243 IntAct P77243 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77243* IntEnz 4.2.1.3 {ECO:0000269|PubMed:11782506, ECO:0000269|PubMed:12473114} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.3 {ECO:0000269|PubMed:11782506, ECO:0000269|PubMed:12473114} IntEnz 4.2.1.79 {ECO:0000269|PubMed:11782506, ECO:0000269|PubMed:12473114} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.79 {ECO:0000269|PubMed:11782506, ECO:0000269|PubMed:12473114} InterPro IPR005656 http://www.ebi.ac.uk/interpro/entry/IPR005656 InterPro IPR012705 http://www.ebi.ac.uk/interpro/entry/IPR012705 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0325 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0325 KEGG_Gene eco:b0334 http://www.genome.jp/dbget-bin/www_bget?eco:b0334 KEGG_Orthology KO:K01720 http://www.genome.jp/dbget-bin/www_bget?KO:K01720 KEGG_Pathway ko00640 http://www.genome.jp/kegg-bin/show_pathway?ko00640 KEGG_Reaction rn:R04424 http://www.genome.jp/dbget-bin/www_bget?rn:R04424 MINT MINT-1309441 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1309441 OMA PECTKHL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PECTKHL PANTHER PTHR16943 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16943 PDB 1SZQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1SZQ PDBsum 1SZQ http://www.ebi.ac.uk/pdbsum/1SZQ PSORT swissprot:PRPD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PRPD_ECOLI PSORT-B swissprot:PRPD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PRPD_ECOLI PSORT2 swissprot:PRPD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PRPD_ECOLI Pfam PF03972 http://pfam.xfam.org/family/PF03972 Phobius swissprot:PRPD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PRPD_ECOLI PhylomeDB P77243 http://phylomedb.org/?seqid=P77243 ProteinModelPortal P77243 http://www.proteinmodelportal.org/query/uniprot/P77243 PubMed 11782506 http://www.ncbi.nlm.nih.gov/pubmed/11782506 PubMed 12473114 http://www.ncbi.nlm.nih.gov/pubmed/12473114 PubMed 15805526 http://www.ncbi.nlm.nih.gov/pubmed/15805526 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22579471 http://www.ncbi.nlm.nih.gov/pubmed/22579471 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414868 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414868 RefSeq WP_001275859 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001275859 SMR P77243 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77243 STRING 511145.b0334 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0334&targetmode=cogs STRING COG2079 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2079&targetmode=cogs SUPFAM SSF103378 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103378 TIGRFAMs TIGR02330 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02330 UniProtKB PRPD_ECOLI http://www.uniprot.org/uniprot/PRPD_ECOLI UniProtKB-AC P77243 http://www.uniprot.org/uniprot/P77243 charge swissprot:PRPD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PRPD_ECOLI eggNOG COG2079 http://eggnogapi.embl.de/nog_data/html/tree/COG2079 eggNOG ENOG4105DXD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DXD epestfind swissprot:PRPD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PRPD_ECOLI garnier swissprot:PRPD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PRPD_ECOLI helixturnhelix swissprot:PRPD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PRPD_ECOLI hmoment swissprot:PRPD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PRPD_ECOLI iep swissprot:PRPD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PRPD_ECOLI inforesidue swissprot:PRPD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PRPD_ECOLI octanol swissprot:PRPD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PRPD_ECOLI pepcoil swissprot:PRPD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PRPD_ECOLI pepdigest swissprot:PRPD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PRPD_ECOLI pepinfo swissprot:PRPD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PRPD_ECOLI pepnet swissprot:PRPD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PRPD_ECOLI pepstats swissprot:PRPD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PRPD_ECOLI pepwheel swissprot:PRPD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PRPD_ECOLI pepwindow swissprot:PRPD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PRPD_ECOLI sigcleave swissprot:PRPD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PRPD_ECOLI ## Database ID URL or Descriptions # BioGrid 4263277 206 # EcoGene EG13362 ydaT # Gene3D 1.10.3600.10 -; 1. # IntAct P76064 3 # InterPro IPR009364 YdaT_toxin # Organism YDAT_ECOLI Escherichia coli (strain K12) # PATRIC 32117994 VBIEscCol129921_1417 # PIR A64886 A64886 # Pfam PF06254 YdaT_toxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDAT_ECOLI Uncharacterized protein YdaT # RefSeq NP_415876 NC_000913.3 # RefSeq WP_000693797 NZ_CP014272.1 BLAST swissprot:YDAT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDAT_ECOLI BioCyc ECOL316407:JW1353-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1353-MONOMER BioCyc EcoCyc:G6682-MONOMER http://biocyc.org/getid?id=EcoCyc:G6682-MONOMER DIP DIP-11627N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11627N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3145 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3145 EcoGene EG13362 http://www.ecogene.org/geneInfo.php?eg_id=EG13362 EnsemblBacteria AAC74440 http://www.ensemblgenomes.org/id/AAC74440 EnsemblBacteria AAC74440 http://www.ensemblgenomes.org/id/AAC74440 EnsemblBacteria BAE76413 http://www.ensemblgenomes.org/id/BAE76413 EnsemblBacteria BAE76413 http://www.ensemblgenomes.org/id/BAE76413 EnsemblBacteria BAE76413 http://www.ensemblgenomes.org/id/BAE76413 EnsemblBacteria b1358 http://www.ensemblgenomes.org/id/b1358 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 1.10.3600.10 http://www.cathdb.info/version/latest/superfamily/1.10.3600.10 GeneID 945924 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945924 HOGENOM HOG000119890 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000119890&db=HOGENOM6 IntAct P76064 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76064* InterPro IPR009364 http://www.ebi.ac.uk/interpro/entry/IPR009364 KEGG_Gene ecj:JW1353 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1353 KEGG_Gene eco:b1358 http://www.genome.jp/dbget-bin/www_bget?eco:b1358 MINT MINT-1289443 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1289443 OMA GETNAQR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GETNAQR PSORT swissprot:YDAT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDAT_ECOLI PSORT-B swissprot:YDAT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDAT_ECOLI PSORT2 swissprot:YDAT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDAT_ECOLI Pfam PF06254 http://pfam.xfam.org/family/PF06254 Phobius swissprot:YDAT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDAT_ECOLI ProteinModelPortal P76064 http://www.proteinmodelportal.org/query/uniprot/P76064 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415876 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415876 RefSeq WP_000693797 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000693797 SMR P76064 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76064 STRING 511145.b1358 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1358&targetmode=cogs UniProtKB YDAT_ECOLI http://www.uniprot.org/uniprot/YDAT_ECOLI UniProtKB-AC P76064 http://www.uniprot.org/uniprot/P76064 charge swissprot:YDAT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDAT_ECOLI epestfind swissprot:YDAT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDAT_ECOLI garnier swissprot:YDAT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDAT_ECOLI helixturnhelix swissprot:YDAT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDAT_ECOLI hmoment swissprot:YDAT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDAT_ECOLI iep swissprot:YDAT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDAT_ECOLI inforesidue swissprot:YDAT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDAT_ECOLI octanol swissprot:YDAT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDAT_ECOLI pepcoil swissprot:YDAT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDAT_ECOLI pepdigest swissprot:YDAT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDAT_ECOLI pepinfo swissprot:YDAT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDAT_ECOLI pepnet swissprot:YDAT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDAT_ECOLI pepstats swissprot:YDAT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDAT_ECOLI pepwheel swissprot:YDAT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDAT_ECOLI pepwindow swissprot:YDAT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDAT_ECOLI sigcleave swissprot:YDAT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDAT_ECOLI ## Database ID URL or Descriptions # BioGrid 4262737 8 # CDD cd10466 FimH_man-bind # EcoGene EG10315 fimH # FUNCTION FIMH_ECOLI Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Adhesin responsible for the binding to D-mannose. It is laterally positioned at intervals in the structure of the type 1 fimbriae. In order to integrate FimH in the fimbriae FimF and FimG are needed. # GO_component GO:0009289 pilus; IMP:EcoCyc. # GO_function GO:0005537 mannose binding; IDA:EcoCyc. # GO_process GO:0007155 cell adhesion; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0007155 cell adhesion # Gene3D 2.60.40.1090 -; 2. # INTERACTION FIMH_ECOLI P31697 fimC; NbExp=6; IntAct=EBI-1028015, EBI-1028005; # IntAct P08191 2 # InterPro IPR000259 Adhesion_dom_fimbrial # InterPro IPR008966 Adhesion_dom # InterPro IPR015243 FimH_man-bd # KEGG_Brite ko02035 Bacterial motility proteins # KEGG_Brite ko02044 Secretion system # Organism FIMH_ECOLI Escherichia coli (strain K12) # PATRIC 32124236 VBIEscCol129921_4461 # PDB 1KIU X-ray; 3.00 A; B/D/F/H/J/L/N/P=22-300 # PDB 1KLF X-ray; 2.79 A; B/D/F/H/J/L/N/P=22-300 # PDB 1QUN X-ray; 2.80 A; B/D/F/H/J/L/N/P=22-300 # PDB 1TR7 X-ray; 2.10 A; A/B=22-179 # PDB 1UWF X-ray; 1.69 A; A=22-179 # PDB 1ZE3 X-ray; 1.84 A; H=179-300 # PDB 2VCO X-ray; 2.10 A; A/B=22-179 # PDB 3RFZ X-ray; 2.80 A; A/D=22-300 # PDB 3ZL1 X-ray; 1.55 A; A/B=22-179 # PDB 3ZL2 X-ray; 1.25 A; A=22-179 # PDB 4ATT X-ray; 1.25 A; A=22-179 # PDB 4AUJ X-ray; 1.53 A; A=22-179 # PDB 4AUU X-ray; 1.60 A; A/B=22-179 # PDB 4AUY X-ray; 2.10 A; A/B=22-179 # PDB 4AV0 X-ray; 2.10 A; A/B=22-179 # PDB 4AV4 X-ray; 1.90 A; A=22-179 # PDB 4AV5 X-ray; 1.40 A; A/B/C/D=22-179 # PDB 4AVH X-ray; 2.10 A; A/B=22-179 # PDB 4AVI X-ray; 2.40 A; A/B=22-179 # PDB 4AVJ X-ray; 2.10 A; A/B=22-179 # PDB 4AVK X-ray; 2.40 A; A/B=22-179 # PDB 4CSS X-ray; 1.07 A; A=22-180 # PDB 4CST X-ray; 1.10 A; A=22-180 # PDB 4J3O X-ray; 3.80 A; H=22-300 # PDB 4LOV X-ray; 1.50 A; A=22-179 # PDB 4X50 X-ray; 2.00 A; A/B=22-180 # PDB 4X5P X-ray; 1.00 A; A=22-180 # PDB 4X5Q X-ray; 1.12 A; A=22-180 # PDB 4X5R X-ray; 1.65 A; A/B/C=22-180 # PDB 4XO8 X-ray; 1.70 A; A/B=22-179 # PDB 4XO9 X-ray; 1.14 A; A=22-300 # PDB 4XOA X-ray; 2.54 A; A/C/E/G=22-300 # PDB 4XOB X-ray; 3.00 A; A/C/E/G=22-300 # PDB 4XOD X-ray; 1.14 A; A=22-300 # PDB 5AB1 X-ray; 1.96 A; A/B=1-300 # PDB 5ABZ X-ray; 2.40 A; A/B=22-179 # PDB 5CGB X-ray; 1.60 A; A/B=22-179 # PDB 5F2F X-ray; 1.67 A; A=22-179 # PIR S56545 S56545 # Pfam PF00419 Fimbrial # Pfam PF09160 FimH_man-bind # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FIMH_ECOLI Protein FimH # RefSeq NP_418740 NC_000913.3 # RefSeq WP_000832247 NZ_LN832404.1 # SIMILARITY Belongs to the fimbrial protein family. {ECO 0000305}. # SUBCELLULAR LOCATION FIMH_ECOLI Fimbrium. # SUPFAM SSF49401 SSF49401; 2 # eggNOG ENOG410643X Bacteria # eggNOG ENOG410Y3E1 LUCA BLAST swissprot:FIMH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FIMH_ECOLI BioCyc ECOL316407:JW4283-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4283-MONOMER BioCyc EcoCyc:EG10315-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10315-MONOMER DIP DIP-9616N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9616N DOI 10.1007/BF00328136 http://dx.doi.org/10.1007/BF00328136 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2002.02915.x http://dx.doi.org/10.1046/j.1365-2958.2002.02915.x DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X05672 http://www.ebi.ac.uk/ena/data/view/X05672 EchoBASE EB0311 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0311 EcoGene EG10315 http://www.ecogene.org/geneInfo.php?eg_id=EG10315 EnsemblBacteria AAC77276 http://www.ensemblgenomes.org/id/AAC77276 EnsemblBacteria AAC77276 http://www.ensemblgenomes.org/id/AAC77276 EnsemblBacteria BAE78313 http://www.ensemblgenomes.org/id/BAE78313 EnsemblBacteria BAE78313 http://www.ensemblgenomes.org/id/BAE78313 EnsemblBacteria BAE78313 http://www.ensemblgenomes.org/id/BAE78313 EnsemblBacteria b4320 http://www.ensemblgenomes.org/id/b4320 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009289 GO_function GO:0005537 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005537 GO_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 Gene3D 2.60.40.1090 http://www.cathdb.info/version/latest/superfamily/2.60.40.1090 GeneID 948847 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948847 HOGENOM HOG000120719 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120719&db=HOGENOM6 IntAct P08191 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P08191* InterPro IPR000259 http://www.ebi.ac.uk/interpro/entry/IPR000259 InterPro IPR008966 http://www.ebi.ac.uk/interpro/entry/IPR008966 InterPro IPR015243 http://www.ebi.ac.uk/interpro/entry/IPR015243 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Brite ko02044 http://www.genome.jp/dbget-bin/www_bget?ko02044 KEGG_Gene ecj:JW4283 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4283 KEGG_Gene eco:b4320 http://www.genome.jp/dbget-bin/www_bget?eco:b4320 KEGG_Orthology KO:K07350 http://www.genome.jp/dbget-bin/www_bget?KO:K07350 OMA DYPGSMA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DYPGSMA PDB 1KIU http://www.ebi.ac.uk/pdbe-srv/view/entry/1KIU PDB 1KLF http://www.ebi.ac.uk/pdbe-srv/view/entry/1KLF PDB 1QUN http://www.ebi.ac.uk/pdbe-srv/view/entry/1QUN PDB 1TR7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1TR7 PDB 1UWF http://www.ebi.ac.uk/pdbe-srv/view/entry/1UWF PDB 1ZE3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZE3 PDB 2VCO http://www.ebi.ac.uk/pdbe-srv/view/entry/2VCO PDB 3RFZ http://www.ebi.ac.uk/pdbe-srv/view/entry/3RFZ PDB 3ZL1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZL1 PDB 3ZL2 http://www.ebi.ac.uk/pdbe-srv/view/entry/3ZL2 PDB 4ATT http://www.ebi.ac.uk/pdbe-srv/view/entry/4ATT PDB 4AUJ http://www.ebi.ac.uk/pdbe-srv/view/entry/4AUJ PDB 4AUU http://www.ebi.ac.uk/pdbe-srv/view/entry/4AUU PDB 4AUY http://www.ebi.ac.uk/pdbe-srv/view/entry/4AUY PDB 4AV0 http://www.ebi.ac.uk/pdbe-srv/view/entry/4AV0 PDB 4AV4 http://www.ebi.ac.uk/pdbe-srv/view/entry/4AV4 PDB 4AV5 http://www.ebi.ac.uk/pdbe-srv/view/entry/4AV5 PDB 4AVH http://www.ebi.ac.uk/pdbe-srv/view/entry/4AVH PDB 4AVI http://www.ebi.ac.uk/pdbe-srv/view/entry/4AVI PDB 4AVJ http://www.ebi.ac.uk/pdbe-srv/view/entry/4AVJ PDB 4AVK http://www.ebi.ac.uk/pdbe-srv/view/entry/4AVK PDB 4CSS http://www.ebi.ac.uk/pdbe-srv/view/entry/4CSS PDB 4CST http://www.ebi.ac.uk/pdbe-srv/view/entry/4CST PDB 4J3O http://www.ebi.ac.uk/pdbe-srv/view/entry/4J3O PDB 4LOV http://www.ebi.ac.uk/pdbe-srv/view/entry/4LOV PDB 4X50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4X50 PDB 4X5P http://www.ebi.ac.uk/pdbe-srv/view/entry/4X5P PDB 4X5Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4X5Q PDB 4X5R http://www.ebi.ac.uk/pdbe-srv/view/entry/4X5R PDB 4XO8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4XO8 PDB 4XO9 http://www.ebi.ac.uk/pdbe-srv/view/entry/4XO9 PDB 4XOA http://www.ebi.ac.uk/pdbe-srv/view/entry/4XOA PDB 4XOB http://www.ebi.ac.uk/pdbe-srv/view/entry/4XOB PDB 4XOD http://www.ebi.ac.uk/pdbe-srv/view/entry/4XOD PDB 5AB1 http://www.ebi.ac.uk/pdbe-srv/view/entry/5AB1 PDB 5ABZ http://www.ebi.ac.uk/pdbe-srv/view/entry/5ABZ PDB 5CGB http://www.ebi.ac.uk/pdbe-srv/view/entry/5CGB PDB 5F2F http://www.ebi.ac.uk/pdbe-srv/view/entry/5F2F PDBsum 1KIU http://www.ebi.ac.uk/pdbsum/1KIU PDBsum 1KLF http://www.ebi.ac.uk/pdbsum/1KLF PDBsum 1QUN http://www.ebi.ac.uk/pdbsum/1QUN PDBsum 1TR7 http://www.ebi.ac.uk/pdbsum/1TR7 PDBsum 1UWF http://www.ebi.ac.uk/pdbsum/1UWF PDBsum 1ZE3 http://www.ebi.ac.uk/pdbsum/1ZE3 PDBsum 2VCO http://www.ebi.ac.uk/pdbsum/2VCO PDBsum 3RFZ http://www.ebi.ac.uk/pdbsum/3RFZ PDBsum 3ZL1 http://www.ebi.ac.uk/pdbsum/3ZL1 PDBsum 3ZL2 http://www.ebi.ac.uk/pdbsum/3ZL2 PDBsum 4ATT http://www.ebi.ac.uk/pdbsum/4ATT PDBsum 4AUJ http://www.ebi.ac.uk/pdbsum/4AUJ PDBsum 4AUU http://www.ebi.ac.uk/pdbsum/4AUU PDBsum 4AUY http://www.ebi.ac.uk/pdbsum/4AUY PDBsum 4AV0 http://www.ebi.ac.uk/pdbsum/4AV0 PDBsum 4AV4 http://www.ebi.ac.uk/pdbsum/4AV4 PDBsum 4AV5 http://www.ebi.ac.uk/pdbsum/4AV5 PDBsum 4AVH http://www.ebi.ac.uk/pdbsum/4AVH PDBsum 4AVI http://www.ebi.ac.uk/pdbsum/4AVI PDBsum 4AVJ http://www.ebi.ac.uk/pdbsum/4AVJ PDBsum 4AVK http://www.ebi.ac.uk/pdbsum/4AVK PDBsum 4CSS http://www.ebi.ac.uk/pdbsum/4CSS PDBsum 4CST http://www.ebi.ac.uk/pdbsum/4CST PDBsum 4J3O http://www.ebi.ac.uk/pdbsum/4J3O PDBsum 4LOV http://www.ebi.ac.uk/pdbsum/4LOV PDBsum 4X50 http://www.ebi.ac.uk/pdbsum/4X50 PDBsum 4X5P http://www.ebi.ac.uk/pdbsum/4X5P PDBsum 4X5Q http://www.ebi.ac.uk/pdbsum/4X5Q PDBsum 4X5R http://www.ebi.ac.uk/pdbsum/4X5R PDBsum 4XO8 http://www.ebi.ac.uk/pdbsum/4XO8 PDBsum 4XO9 http://www.ebi.ac.uk/pdbsum/4XO9 PDBsum 4XOA http://www.ebi.ac.uk/pdbsum/4XOA PDBsum 4XOB http://www.ebi.ac.uk/pdbsum/4XOB PDBsum 4XOD http://www.ebi.ac.uk/pdbsum/4XOD PDBsum 5AB1 http://www.ebi.ac.uk/pdbsum/5AB1 PDBsum 5ABZ http://www.ebi.ac.uk/pdbsum/5ABZ PDBsum 5CGB http://www.ebi.ac.uk/pdbsum/5CGB PDBsum 5F2F http://www.ebi.ac.uk/pdbsum/5F2F PSORT swissprot:FIMH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FIMH_ECOLI PSORT-B swissprot:FIMH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FIMH_ECOLI PSORT2 swissprot:FIMH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FIMH_ECOLI Pfam PF00419 http://pfam.xfam.org/family/PF00419 Pfam PF09160 http://pfam.xfam.org/family/PF09160 Phobius swissprot:FIMH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FIMH_ECOLI ProteinModelPortal P08191 http://www.proteinmodelportal.org/query/uniprot/P08191 PubMed 12010488 http://www.ncbi.nlm.nih.gov/pubmed/12010488 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1971261 http://www.ncbi.nlm.nih.gov/pubmed/1971261 PubMed 2890081 http://www.ncbi.nlm.nih.gov/pubmed/2890081 PubMed 2900235 http://www.ncbi.nlm.nih.gov/pubmed/2900235 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 7905476 http://www.ncbi.nlm.nih.gov/pubmed/7905476 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418740 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418740 RefSeq WP_000832247 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000832247 SMR P08191 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P08191 STRING 511145.b4320 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4320&targetmode=cogs SUPFAM SSF49401 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49401 UniProtKB FIMH_ECOLI http://www.uniprot.org/uniprot/FIMH_ECOLI UniProtKB-AC P08191 http://www.uniprot.org/uniprot/P08191 charge swissprot:FIMH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FIMH_ECOLI eggNOG ENOG410643X http://eggnogapi.embl.de/nog_data/html/tree/ENOG410643X eggNOG ENOG410Y3E1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y3E1 epestfind swissprot:FIMH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FIMH_ECOLI garnier swissprot:FIMH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FIMH_ECOLI helixturnhelix swissprot:FIMH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FIMH_ECOLI hmoment swissprot:FIMH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FIMH_ECOLI iep swissprot:FIMH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FIMH_ECOLI inforesidue swissprot:FIMH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FIMH_ECOLI octanol swissprot:FIMH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FIMH_ECOLI pepcoil swissprot:FIMH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FIMH_ECOLI pepdigest swissprot:FIMH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FIMH_ECOLI pepinfo swissprot:FIMH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FIMH_ECOLI pepnet swissprot:FIMH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FIMH_ECOLI pepstats swissprot:FIMH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FIMH_ECOLI pepwheel swissprot:FIMH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FIMH_ECOLI pepwindow swissprot:FIMH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FIMH_ECOLI sigcleave swissprot:FIMH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FIMH_ECOLI ## Database ID URL or Descriptions # AltName SYR_ECOLI Arginyl-tRNA synthetase # BRENDA 6.1.1.19 2026 # CATALYTIC ACTIVITY SYR_ECOLI ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). # EcoGene EG10071 argS # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004814 arginine-tRNA ligase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006420 arginyl-tRNA aminoacylation; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0006520 cellular amino acid metabolic process # Gene3D 1.10.730.10 -; 1. # Gene3D 3.30.1360.70 -; 1. # Gene3D 3.40.50.620 -; 1. # HAMAP MF_00123 Arg_tRNA_synth # IntAct P11875 10 # InterPro IPR001278 Arg-tRNA-ligase # InterPro IPR001412 aa-tRNA-synth_I_CS # InterPro IPR005148 Arg-tRNA-synth_N # InterPro IPR008909 DALR_anticod-bd # InterPro IPR009080 tRNAsynth_Ia_anticodon-bd # InterPro IPR014729 Rossmann-like_a/b/a_fold # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01007 Amino acid related enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # KEGG_Pathway ko00970 Aminoacyl-tRNA biosynthesis # Organism SYR_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11956 PTHR11956 # PATRIC 32119077 VBIEscCol129921_1956 # PDB 4OBY X-ray; 2.57 A; A=1-577 # PIR JS0267 SYECRT # PRINTS PR01038 TRNASYNTHARG # PROSITE PS00178 AA_TRNA_LIGASE_I # Pfam PF00750 tRNA-synt_1d # Pfam PF03485 Arg_tRNA_synt_N # Pfam PF05746 DALR_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SYR_ECOLI Arginine--tRNA ligase # RefSeq NP_416390 NC_000913.3 # RefSeq WP_001025322 NZ_LN832404.1 # SIMILARITY Belongs to the class-I aminoacyl-tRNA synthetase family. {ECO 0000305}. # SMART SM00836 DALR_1 # SMART SM01016 Arg_tRNA_synt_N # SUBCELLULAR LOCATION SYR_ECOLI Cytoplasm. # SUBUNIT SYR_ECOLI Monomer. # SUPFAM SSF47323 SSF47323 # SUPFAM SSF55190 SSF55190 # TIGRFAMs TIGR00456 argS # eggNOG COG0018 LUCA # eggNOG ENOG4105C75 Bacteria BLAST swissprot:SYR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SYR_ECOLI BioCyc ECOL316407:JW1865-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1865-MONOMER BioCyc EcoCyc:ARGS-MONOMER http://biocyc.org/getid?id=EcoCyc:ARGS-MONOMER BioCyc MetaCyc:ARGS-MONOMER http://biocyc.org/getid?id=MetaCyc:ARGS-MONOMER COG COG0018 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0018 DIP DIP-9147N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9147N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/nar/17.14.5725 http://dx.doi.org/10.1093/nar/17.14.5725 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.1.1.19 http://www.genome.jp/dbget-bin/www_bget?EC:6.1.1.19 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X15320 http://www.ebi.ac.uk/ena/data/view/X15320 ENZYME 6.1.1.19 http://enzyme.expasy.org/EC/6.1.1.19 EchoBASE EB0069 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0069 EcoGene EG10071 http://www.ecogene.org/geneInfo.php?eg_id=EG10071 EnsemblBacteria AAC74946 http://www.ensemblgenomes.org/id/AAC74946 EnsemblBacteria AAC74946 http://www.ensemblgenomes.org/id/AAC74946 EnsemblBacteria BAA15686 http://www.ensemblgenomes.org/id/BAA15686 EnsemblBacteria BAA15686 http://www.ensemblgenomes.org/id/BAA15686 EnsemblBacteria BAA15686 http://www.ensemblgenomes.org/id/BAA15686 EnsemblBacteria b1876 http://www.ensemblgenomes.org/id/b1876 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004814 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004814 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006420 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006420 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 Gene3D 1.10.730.10 http://www.cathdb.info/version/latest/superfamily/1.10.730.10 Gene3D 3.30.1360.70 http://www.cathdb.info/version/latest/superfamily/3.30.1360.70 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 GeneID 946452 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946452 HAMAP MF_00123 http://hamap.expasy.org/unirule/MF_00123 HOGENOM HOG000247212 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000247212&db=HOGENOM6 InParanoid P11875 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P11875 IntAct P11875 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P11875* IntEnz 6.1.1.19 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.1.1.19 InterPro IPR001278 http://www.ebi.ac.uk/interpro/entry/IPR001278 InterPro IPR001412 http://www.ebi.ac.uk/interpro/entry/IPR001412 InterPro IPR005148 http://www.ebi.ac.uk/interpro/entry/IPR005148 InterPro IPR008909 http://www.ebi.ac.uk/interpro/entry/IPR008909 InterPro IPR009080 http://www.ebi.ac.uk/interpro/entry/IPR009080 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW1865 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1865 KEGG_Gene eco:b1876 http://www.genome.jp/dbget-bin/www_bget?eco:b1876 KEGG_Orthology KO:K01887 http://www.genome.jp/dbget-bin/www_bget?KO:K01887 KEGG_Pathway ko00970 http://www.genome.jp/kegg-bin/show_pathway?ko00970 KEGG_Reaction rn:R03646 http://www.genome.jp/dbget-bin/www_bget?rn:R03646 MINT MINT-1241236 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1241236 OMA HVGHIRN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HVGHIRN PANTHER PTHR11956 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11956 PDB 4OBY http://www.ebi.ac.uk/pdbe-srv/view/entry/4OBY PDBsum 4OBY http://www.ebi.ac.uk/pdbsum/4OBY PRINTS PR01038 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01038 PROSITE PS00178 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00178 PSORT swissprot:SYR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SYR_ECOLI PSORT-B swissprot:SYR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SYR_ECOLI PSORT2 swissprot:SYR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SYR_ECOLI Pfam PF00750 http://pfam.xfam.org/family/PF00750 Pfam PF03485 http://pfam.xfam.org/family/PF03485 Pfam PF05746 http://pfam.xfam.org/family/PF05746 Phobius swissprot:SYR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SYR_ECOLI PhylomeDB P11875 http://phylomedb.org/?seqid=P11875 ProteinModelPortal P11875 http://www.proteinmodelportal.org/query/uniprot/P11875 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2668891 http://www.ncbi.nlm.nih.gov/pubmed/2668891 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_416390 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416390 RefSeq WP_001025322 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001025322 SMART SM00836 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00836 SMART SM01016 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01016 SMR P11875 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P11875 STRING 511145.b1876 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1876&targetmode=cogs STRING COG0018 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0018&targetmode=cogs SUPFAM SSF47323 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47323 SUPFAM SSF55190 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55190 SWISS-2DPAGE P11875 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P11875 TIGRFAMs TIGR00456 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00456 UniProtKB SYR_ECOLI http://www.uniprot.org/uniprot/SYR_ECOLI UniProtKB-AC P11875 http://www.uniprot.org/uniprot/P11875 charge swissprot:SYR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SYR_ECOLI eggNOG COG0018 http://eggnogapi.embl.de/nog_data/html/tree/COG0018 eggNOG ENOG4105C75 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C75 epestfind swissprot:SYR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SYR_ECOLI garnier swissprot:SYR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SYR_ECOLI helixturnhelix swissprot:SYR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SYR_ECOLI hmoment swissprot:SYR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SYR_ECOLI iep swissprot:SYR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SYR_ECOLI inforesidue swissprot:SYR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SYR_ECOLI octanol swissprot:SYR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SYR_ECOLI pepcoil swissprot:SYR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SYR_ECOLI pepdigest swissprot:SYR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SYR_ECOLI pepinfo swissprot:SYR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SYR_ECOLI pepnet swissprot:SYR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SYR_ECOLI pepstats swissprot:SYR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SYR_ECOLI pepwheel swissprot:SYR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SYR_ECOLI pepwindow swissprot:SYR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SYR_ECOLI sigcleave swissprot:SYR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SYR_ECOLI ## Database ID URL or Descriptions # BIOTECHNOLOGY Expression leads to increased levels of N-acylated L-amino acids which could be used in a number of applications. {ECO 0000269|Ref.4}. # BioGrid 4260194 12 # CATALYTIC ACTIVITY MNAT_ECOLI Acetyl-CoA + L-methionine = CoA + N-acetyl-L- methionine. # EcoGene EG13770 mnaT # FUNCTION MNAT_ECOLI N-acylates some free L-amino acids and their derivatives using a CoA thioester as cofactor. Using acetyl-CoA as a cofactor, substrate specificity is methionine sulfone > methionine sulfoximine > methionine sulfoxide > methionine. Asparagine, lysine, glutamine, aspartate and glutamate are very poor substrates. Using methionine as a substrate, cofactor preference is propionyl-CoA > acetyl-CoA >> butyryl-CoA. {ECO 0000269|Ref.4}. # GO_component GO:0031248 protein acetyltransferase complex; IBA:GO_Central. # GO_function GO:0004596 peptide alpha-N-acetyltransferase activity; IBA:GO_Central. # GO_process GO:0006474 N-terminal protein amino acid acetylation; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0006464 cellular protein modification process # Gene3D 3.40.630.30 -; 1. # InterPro IPR000182 GNAT_dom # InterPro IPR016181 Acyl_CoA_acyltransferase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00440 Phosphonate and phosphinate metabolism # Organism MNAT_ECOLI Escherichia coli (strain K12) # PATRIC 32118188 VBIEscCol129921_1514 # PIR C64897 C64897 # PROSITE PS51186 GNAT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MNAT_ECOLI L-amino acid N-acyltransferase MnaT # RefSeq NP_415965 NC_000913.3 # RefSeq WP_001310799 NZ_LN832404.1 # SIMILARITY Belongs to the acetyltransferase family. PAT/BAR subfamily. {ECO 0000305}. # SIMILARITY Contains 1 N-acetyltransferase domain. {ECO:0000255|PROSITE-ProRule PRU00532}. # SUPFAM SSF55729 SSF55729 # eggNOG COG1247 LUCA # eggNOG ENOG4108Z7F Bacteria BLAST swissprot:MNAT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MNAT_ECOLI BioCyc ECOL316407:JW5233-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5233-MONOMER BioCyc EcoCyc:G6759-MONOMER http://biocyc.org/getid?id=EcoCyc:G6759-MONOMER BioCyc MetaCyc:G6759-MONOMER http://biocyc.org/getid?id=MetaCyc:G6759-MONOMER COG COG1247 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1247 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.3.1.- http://enzyme.expasy.org/EC/2.3.1.- EchoBASE EB3533 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3533 EcoGene EG13770 http://www.ecogene.org/geneInfo.php?eg_id=EG13770 EnsemblBacteria AAC74530 http://www.ensemblgenomes.org/id/AAC74530 EnsemblBacteria AAC74530 http://www.ensemblgenomes.org/id/AAC74530 EnsemblBacteria BAA15080 http://www.ensemblgenomes.org/id/BAA15080 EnsemblBacteria BAA15080 http://www.ensemblgenomes.org/id/BAA15080 EnsemblBacteria BAA15080 http://www.ensemblgenomes.org/id/BAA15080 EnsemblBacteria b1448 http://www.ensemblgenomes.org/id/b1448 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0031248 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031248 GO_function GO:0004596 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004596 GO_process GO:0006474 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006474 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 Gene3D 3.40.630.30 http://www.cathdb.info/version/latest/superfamily/3.40.630.30 GeneID 946010 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946010 HOGENOM HOG000078516 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000078516&db=HOGENOM6 InParanoid P76112 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76112 IntEnz 2.3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1 InterPro IPR000182 http://www.ebi.ac.uk/interpro/entry/IPR000182 InterPro IPR016181 http://www.ebi.ac.uk/interpro/entry/IPR016181 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5233 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5233 KEGG_Gene eco:b1448 http://www.genome.jp/dbget-bin/www_bget?eco:b1448 KEGG_Orthology KO:K03823 http://www.genome.jp/dbget-bin/www_bget?KO:K03823 KEGG_Pathway ko00440 http://www.genome.jp/kegg-bin/show_pathway?ko00440 KEGG_Reaction rn:R08871 http://www.genome.jp/dbget-bin/www_bget?rn:R08871 KEGG_Reaction rn:R08938 http://www.genome.jp/dbget-bin/www_bget?rn:R08938 OMA VTGQMPQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VTGQMPQ PROSITE PS51186 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51186 PSORT swissprot:MNAT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MNAT_ECOLI PSORT-B swissprot:MNAT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MNAT_ECOLI PSORT2 swissprot:MNAT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MNAT_ECOLI Phobius swissprot:MNAT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MNAT_ECOLI PhylomeDB P76112 http://phylomedb.org/?seqid=P76112 ProteinModelPortal P76112 http://www.proteinmodelportal.org/query/uniprot/P76112 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415965 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415965 RefSeq WP_001310799 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001310799 SMR P76112 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76112 STRING 511145.b1448 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1448&targetmode=cogs STRING COG1247 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1247&targetmode=cogs SUPFAM SSF55729 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55729 UniProtKB MNAT_ECOLI http://www.uniprot.org/uniprot/MNAT_ECOLI UniProtKB-AC P76112 http://www.uniprot.org/uniprot/P76112 charge swissprot:MNAT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MNAT_ECOLI eggNOG COG1247 http://eggnogapi.embl.de/nog_data/html/tree/COG1247 eggNOG ENOG4108Z7F http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108Z7F epestfind swissprot:MNAT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MNAT_ECOLI garnier swissprot:MNAT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MNAT_ECOLI helixturnhelix swissprot:MNAT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MNAT_ECOLI hmoment swissprot:MNAT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MNAT_ECOLI iep swissprot:MNAT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MNAT_ECOLI inforesidue swissprot:MNAT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MNAT_ECOLI octanol swissprot:MNAT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MNAT_ECOLI pepcoil swissprot:MNAT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MNAT_ECOLI pepdigest swissprot:MNAT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MNAT_ECOLI pepinfo swissprot:MNAT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MNAT_ECOLI pepnet swissprot:MNAT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MNAT_ECOLI pepstats swissprot:MNAT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MNAT_ECOLI pepwheel swissprot:MNAT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MNAT_ECOLI pepwindow swissprot:MNAT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MNAT_ECOLI sigcleave swissprot:MNAT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MNAT_ECOLI ## Database ID URL or Descriptions # AltName CYOE_ECOLI Heme B farnesyltransferase # AltName CYOE_ECOLI Heme O synthase # BRENDA 2.5.1.B36 2026 # BioGrid 4259839 2 # CDD cd13957 PT_UbiA_Cox10 # EcoGene EG10182 cyoE # FUNCTION CYOE_ECOLI Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. {ECO 0000269|PubMed 1336371, ECO 0000269|PubMed 8253713}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0008495 protoheme IX farnesyltransferase activity; IDA:EcoliWiki. # GO_process GO:0048034 heme O biosynthetic process; IDA:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0051186 cofactor metabolic process # HAMAP MF_00154 CyoE_CtaB # InterPro IPR000537 UbiA_prenyltransferase # InterPro IPR006369 Protohaem_IX_farnesylTrfase # InterPro IPR030470 UbiA_prenylTrfase_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01006 Prenyltransferases # KEGG_Pathway ko00190 Oxidative phosphorylation # KEGG_Pathway ko00860 Porphyrin and chlorophyll metabolism # MISCELLANEOUS CYOE_ECOLI Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature. # Organism CYOE_ECOLI Escherichia coli (strain K12) # PATHWAY Porphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme step 1/1. # PATRIC 32116007 VBIEscCol129921_0445 # PIR E42226 E42226 # PROSITE PS00943 UBIA # Pfam PF01040 UbiA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CYOE_ECOLI Protoheme IX farnesyltransferase # RefSeq NP_414962 NC_000913.3 # RefSeq WP_000971336 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40184.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION CYOE_ECOLI Cell inner membrane; Multi-pass membrane protein. # TIGRFAMs TIGR01473 cyoE_ctaB # UniPathway UPA00834 UER00712 # eggNOG COG0109 LUCA # eggNOG ENOG4105F1R Bacteria BLAST swissprot:CYOE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CYOE_ECOLI BioCyc ECOL316407:JW0418-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0418-MONOMER BioCyc EcoCyc:HEMEOSYN-MONOMER http://biocyc.org/getid?id=EcoCyc:HEMEOSYN-MONOMER BioCyc MetaCyc:HEMEOSYN-MONOMER http://biocyc.org/getid?id=MetaCyc:HEMEOSYN-MONOMER COG COG0109 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0109 DIP DIP-47946N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47946N DOI 10.1016/0006-291X(92)90243-E http://dx.doi.org/10.1016/0006-291X(92)90243-E DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.5.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.5.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J05492 http://www.ebi.ac.uk/ena/data/view/J05492 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 ENZYME 2.5.1.- http://enzyme.expasy.org/EC/2.5.1.- EchoBASE EB0179 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0179 EcoGene EG10182 http://www.ecogene.org/geneInfo.php?eg_id=EG10182 EnsemblBacteria AAC73531 http://www.ensemblgenomes.org/id/AAC73531 EnsemblBacteria AAC73531 http://www.ensemblgenomes.org/id/AAC73531 EnsemblBacteria BAE76208 http://www.ensemblgenomes.org/id/BAE76208 EnsemblBacteria BAE76208 http://www.ensemblgenomes.org/id/BAE76208 EnsemblBacteria BAE76208 http://www.ensemblgenomes.org/id/BAE76208 EnsemblBacteria b0428 http://www.ensemblgenomes.org/id/b0428 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0008495 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008495 GO_process GO:0048034 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048034 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016765 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 GeneID 945073 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945073 HAMAP MF_00154 http://hamap.expasy.org/unirule/MF_00154 HOGENOM HOG000237290 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000237290&db=HOGENOM6 InParanoid P0AEA5 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEA5 IntEnz 2.5.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.5.1 InterPro IPR000537 http://www.ebi.ac.uk/interpro/entry/IPR000537 InterPro IPR006369 http://www.ebi.ac.uk/interpro/entry/IPR006369 InterPro IPR030470 http://www.ebi.ac.uk/interpro/entry/IPR030470 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01006 http://www.genome.jp/dbget-bin/www_bget?ko01006 KEGG_Gene ecj:JW0418 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0418 KEGG_Gene eco:b0428 http://www.genome.jp/dbget-bin/www_bget?eco:b0428 KEGG_Orthology KO:K02301 http://www.genome.jp/dbget-bin/www_bget?KO:K02301 KEGG_Pathway ko00190 http://www.genome.jp/kegg-bin/show_pathway?ko00190 KEGG_Pathway ko00860 http://www.genome.jp/kegg-bin/show_pathway?ko00860 KEGG_Reaction rn:R07411 http://www.genome.jp/dbget-bin/www_bget?rn:R07411 OMA IWWLGMA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IWWLGMA PROSITE PS00943 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00943 PSORT swissprot:CYOE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CYOE_ECOLI PSORT-B swissprot:CYOE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CYOE_ECOLI PSORT2 swissprot:CYOE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CYOE_ECOLI Pfam PF01040 http://pfam.xfam.org/family/PF01040 Phobius swissprot:CYOE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CYOE_ECOLI PhylomeDB P0AEA5 http://phylomedb.org/?seqid=P0AEA5 ProteinModelPortal P0AEA5 http://www.proteinmodelportal.org/query/uniprot/P0AEA5 PubMed 1336371 http://www.ncbi.nlm.nih.gov/pubmed/1336371 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2162835 http://www.ncbi.nlm.nih.gov/pubmed/2162835 PubMed 2165491 http://www.ncbi.nlm.nih.gov/pubmed/2165491 PubMed 8253713 http://www.ncbi.nlm.nih.gov/pubmed/8253713 PubMed 8262927 http://www.ncbi.nlm.nih.gov/pubmed/8262927 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414962 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414962 RefSeq WP_000971336 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000971336 STRING 511145.b0428 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0428&targetmode=cogs STRING COG0109 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0109&targetmode=cogs TIGRFAMs TIGR01473 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01473 UniProtKB CYOE_ECOLI http://www.uniprot.org/uniprot/CYOE_ECOLI UniProtKB-AC P0AEA5 http://www.uniprot.org/uniprot/P0AEA5 charge swissprot:CYOE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CYOE_ECOLI eggNOG COG0109 http://eggnogapi.embl.de/nog_data/html/tree/COG0109 eggNOG ENOG4105F1R http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F1R epestfind swissprot:CYOE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CYOE_ECOLI garnier swissprot:CYOE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CYOE_ECOLI helixturnhelix swissprot:CYOE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CYOE_ECOLI hmoment swissprot:CYOE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CYOE_ECOLI iep swissprot:CYOE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CYOE_ECOLI inforesidue swissprot:CYOE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CYOE_ECOLI octanol swissprot:CYOE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CYOE_ECOLI pepcoil swissprot:CYOE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CYOE_ECOLI pepdigest swissprot:CYOE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CYOE_ECOLI pepinfo swissprot:CYOE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CYOE_ECOLI pepnet swissprot:CYOE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CYOE_ECOLI pepstats swissprot:CYOE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CYOE_ECOLI pepwheel swissprot:CYOE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CYOE_ECOLI pepwindow swissprot:CYOE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CYOE_ECOLI sigcleave swissprot:CYOE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CYOE_ECOLI ## Database ID URL or Descriptions # AltName IBPA_ECOLI 16 kDa heat shock protein A # BioGrid 4262590 160 # EcoGene EG11534 ibpA # FUNCTION IBPA_ECOLI Associates with aggregated proteins, together with IbpB, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP- independent. {ECO 0000269|PubMed 12055295, ECO 0000269|PubMed 12071954}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IPI:IntAct. # GO_process GO:0009408 response to heat; IMP:EcoCyc. # GO_process GO:0050821 protein stabilization; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # Gene3D 2.60.40.790 -; 1. # HAMAP MF_02000 HSP20_IbpA # INDUCTION IBPA_ECOLI By heat shock. # INTERACTION IBPA_ECOLI Self; NbExp=3; IntAct=EBI-550729, EBI-550729; P0C058 ibpB; NbExp=3; IntAct=EBI-550729, EBI-552784; # IntAct P0C054 45 # InterPro IPR002068 A-crystallin/Hsp20_dom # InterPro IPR008978 HSP20-like_chaperone # InterPro IPR023728 HSP20_IbpA # InterPro IPR031107 HSP20 # KEGG_Brite ko03110 Chaperones and folding catalysts # Organism IBPA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11527 PTHR11527 # PATRIC 32122867 VBIEscCol129921_3809 # PIR A45245 A45245 # PROSITE PS01031 HSP20 # Pfam PF00011 HSP20 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName IBPA_ECOLI Small heat shock protein IbpA # RefSeq NP_418142 NC_000913.3 # RefSeq WP_001243437 NZ_LN832404.1 # SIMILARITY Belongs to the small heat shock protein (HSP20) family. {ECO 0000305}. # SUBCELLULAR LOCATION IBPA_ECOLI Cytoplasm {ECO 0000269|PubMed 14702418}. # SUBUNIT Monomer. Forms homomultimers of about 100-150 subunits at optimal growth temperatures. Conformation changes to monomers at high temperatures or high ionic concentrations. {ECO:0000269|PubMed 12071954}. # SUPFAM SSF49764 SSF49764 # eggNOG COG0071 LUCA # eggNOG ENOG4108ZNX Bacteria BLAST swissprot:IBPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:IBPA_ECOLI BioCyc ECOL316407:JW3664-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3664-MONOMER BioCyc EcoCyc:EG11534-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11534-MONOMER COG COG0071 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0071 DIP DIP-47849N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47849N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2003.03710.x http://dx.doi.org/10.1046/j.1365-2958.2003.03710.x DOI 10.1046/j.1432-1033.2002.02958.x http://dx.doi.org/10.1046/j.1432-1033.2002.02958.x DOI 10.1074/jbc.M412706200 http://dx.doi.org/10.1074/jbc.M412706200 DOI 10.1099/mic.0.26470-0 http://dx.doi.org/10.1099/mic.0.26470-0 DOI 10.1111/j.1574-6968.2000.tb09009.x http://dx.doi.org/10.1111/j.1574-6968.2000.tb09009.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M94104 http://www.ebi.ac.uk/ena/data/view/M94104 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1496 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1496 EcoGene EG11534 http://www.ecogene.org/geneInfo.php?eg_id=EG11534 EnsemblBacteria AAC76710 http://www.ensemblgenomes.org/id/AAC76710 EnsemblBacteria AAC76710 http://www.ensemblgenomes.org/id/AAC76710 EnsemblBacteria BAE77607 http://www.ensemblgenomes.org/id/BAE77607 EnsemblBacteria BAE77607 http://www.ensemblgenomes.org/id/BAE77607 EnsemblBacteria BAE77607 http://www.ensemblgenomes.org/id/BAE77607 EnsemblBacteria b3687 http://www.ensemblgenomes.org/id/b3687 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GO_process GO:0050821 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050821 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 2.60.40.790 http://www.cathdb.info/version/latest/superfamily/2.60.40.790 GeneID 948200 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948200 HAMAP MF_02000 http://hamap.expasy.org/unirule/MF_02000 HOGENOM HOG000251750 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000251750&db=HOGENOM6 InParanoid P0C054 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0C054 IntAct P0C054 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0C054* InterPro IPR002068 http://www.ebi.ac.uk/interpro/entry/IPR002068 InterPro IPR008978 http://www.ebi.ac.uk/interpro/entry/IPR008978 InterPro IPR023728 http://www.ebi.ac.uk/interpro/entry/IPR023728 InterPro IPR031107 http://www.ebi.ac.uk/interpro/entry/IPR031107 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW3664 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3664 KEGG_Gene eco:b3687 http://www.genome.jp/dbget-bin/www_bget?eco:b3687 KEGG_Orthology KO:K04080 http://www.genome.jp/dbget-bin/www_bget?KO:K04080 MINT MINT-1219330 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1219330 OMA TAHDNML http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TAHDNML PANTHER PTHR11527 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11527 PROSITE PS01031 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01031 PSORT swissprot:IBPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:IBPA_ECOLI PSORT-B swissprot:IBPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:IBPA_ECOLI PSORT2 swissprot:IBPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:IBPA_ECOLI Pfam PF00011 http://pfam.xfam.org/family/PF00011 Phobius swissprot:IBPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:IBPA_ECOLI PhylomeDB P0C054 http://phylomedb.org/?seqid=P0C054 ProteinModelPortal P0C054 http://www.proteinmodelportal.org/query/uniprot/P0C054 PubMed 10713416 http://www.ncbi.nlm.nih.gov/pubmed/10713416 PubMed 12055295 http://www.ncbi.nlm.nih.gov/pubmed/12055295 PubMed 12071954 http://www.ncbi.nlm.nih.gov/pubmed/12071954 PubMed 1356969 http://www.ncbi.nlm.nih.gov/pubmed/1356969 PubMed 14617181 http://www.ncbi.nlm.nih.gov/pubmed/14617181 PubMed 14702418 http://www.ncbi.nlm.nih.gov/pubmed/14702418 PubMed 15665332 http://www.ncbi.nlm.nih.gov/pubmed/15665332 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_418142 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418142 RefSeq WP_001243437 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001243437 SMR P0C054 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0C054 STRING 511145.b3687 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3687&targetmode=cogs STRING COG0071 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0071&targetmode=cogs SUPFAM SSF49764 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49764 SWISS-2DPAGE P0C054 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0C054 UniProtKB IBPA_ECOLI http://www.uniprot.org/uniprot/IBPA_ECOLI UniProtKB-AC P0C054 http://www.uniprot.org/uniprot/P0C054 charge swissprot:IBPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:IBPA_ECOLI eggNOG COG0071 http://eggnogapi.embl.de/nog_data/html/tree/COG0071 eggNOG ENOG4108ZNX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ZNX epestfind swissprot:IBPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:IBPA_ECOLI garnier swissprot:IBPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:IBPA_ECOLI helixturnhelix swissprot:IBPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:IBPA_ECOLI hmoment swissprot:IBPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:IBPA_ECOLI iep swissprot:IBPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:IBPA_ECOLI inforesidue swissprot:IBPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:IBPA_ECOLI octanol swissprot:IBPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:IBPA_ECOLI pepcoil swissprot:IBPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:IBPA_ECOLI pepdigest swissprot:IBPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:IBPA_ECOLI pepinfo swissprot:IBPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:IBPA_ECOLI pepnet swissprot:IBPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:IBPA_ECOLI pepstats swissprot:IBPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:IBPA_ECOLI pepwheel swissprot:IBPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:IBPA_ECOLI pepwindow swissprot:IBPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:IBPA_ECOLI sigcleave swissprot:IBPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:IBPA_ECOLI ## Database ID URL or Descriptions # AltName YAFQ_ECOLI Endoribonuclease YafQ # AltName YAFQ_ECOLI Toxin YafQ # BioGrid 4259771 15 # DEVELOPMENTAL STAGE May function as a drug tolerance determinant in biofilm, but not stationary phase planktonic cells. {ECO:0000269|PubMed 19707553}. # DISRUPTION PHENOTYPE YAFQ_ECOLI Cells missing yafQ show increased biofilm sensitivity to the antibiotics cefazolin (a beta-lactam inhibitor) and tobramycin (a protein synthesis inhibitor). There is no difference in antibiotic sensitivity in stationary phase planktonic cells. Cells missing dinJ-yafQ have reduced biofilm formation. {ECO 0000269|PubMed 19307375, ECO 0000269|PubMed 19707553}. # EcoGene EG13154 yafQ # FUNCTION YAFQ_ECOLI Cell death governed by the MazE-MazF and DinJ-YafQ TA modules seems to play a role in biofilm formation. # FUNCTION YAFQ_ECOLI Toxic component of a toxin-antitoxin (TA) module. A sequence-specific mRNA endoribonuclease that inhibits translation elongation and induces bacterial stasis. Cleavage occurs between the second and third residue of the Lys codon followed by a G or A (5'AAA(G/A)3'), is reading-frame dependent and occurs within the 5' end of most mRNAs. Ribosome-binding confers the sequence specificity and reading frame-dependence. When overexpressed in liquid media YafQ partially inhibits protein synthesis, with a reduction in growth rate and colony growth rate. This effect is counteracted by coexpression with DinJ, the YafQ antitoxin. YafQ and DinJ together bind their own promoter, and by analogy to other TA modules probably repress its expression. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003723 RNA binding; IEA:UniProtKB-KW. # GO_function GO:0004521 endoribonuclease activity; IDA:EcoCyc. # GO_function GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters; IDA:EcoCyc. # GO_function GO:0043022 ribosome binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006355 regulation of transcription, DNA-templated; IEA:UniProtKB-KW. # GO_process GO:0006402 mRNA catabolic process; IDA:EcoCyc. # GO_process GO:0006415 translational termination; IDA:EcoCyc. # GO_process GO:0044010 single-species biofilm formation; IMP:EcoCyc. # GO_process GO:0046677 response to antibiotic; IMP:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0004518 nuclease activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # INDUCTION By the DNA damaging agent mitomycin C. {ECO:0000269|PubMed 19210620}. # IntAct Q47149 4 # InterPro IPR004386 Toxin_YafQ-like # InterPro IPR007712 RelE/ParE_toxin # Organism YAFQ_ECOLI Escherichia coli (strain K12) # PATRIC 32115565 VBIEscCol129921_0227 # PDB 4ML2 X-ray; 1.50 A; A=1-92 # PDB 4MMG X-ray; 1.50 A; A/B=1-92 # PDB 4Q2U X-ray; 1.80 A; B/D/F/H/J/L/N/P=2-92 # PIR B64747 B64747 # PIRSF PIRSF006156 YafQ # Pfam PF15738 YafQ_toxin # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAFQ_ECOLI mRNA interferase YafQ # RefSeq NP_414760 NC_000913.3 # RefSeq WP_000615983 NZ_LN832404.1 # SIMILARITY To H.influenzae HI_0711. {ECO 0000305}. # SUBUNIT YAFQ_ECOLI Forms a complex with antitoxin DinJ, possibly a heterotetramer. In this complex the toxin activity is inhibited. Binds the 70S ribosome via the 50S ribosomal subunit. {ECO 0000269|PubMed 17263853, ECO 0000269|PubMed 19210620}. # TIGRFAMs TIGR00053 TIGR00053 # TIGRFAMs TIGR02385 RelE_StbE # eggNOG COG3041 LUCA # eggNOG ENOG4105VXN Bacteria BLAST swissprot:YAFQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAFQ_ECOLI BioCyc ECOL316407:JW0215-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0215-MONOMER BioCyc EcoCyc:G6109-MONOMER http://biocyc.org/getid?id=EcoCyc:G6109-MONOMER BioCyc MetaCyc:G6109-MONOMER http://biocyc.org/getid?id=MetaCyc:G6109-MONOMER DIP DIP-11221N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11221N DOI 10.1016/0165-7992(95)90024-1 http://dx.doi.org/10.1016/0165-7992(95)90024-1 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.2008.06572.x http://dx.doi.org/10.1111/j.1365-2958.2008.06572.x DOI 10.1111/j.1574-6968.2006.00563.x http://dx.doi.org/10.1111/j.1574-6968.2006.00563.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/AAC.00043-09 http://dx.doi.org/10.1128/AAC.00043-09 DOI 10.1371/journal.pone.0006785 http://dx.doi.org/10.1371/journal.pone.0006785 EC_number EC:3.1.-.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D38582 http://www.ebi.ac.uk/ena/data/view/D38582 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.-.- http://enzyme.expasy.org/EC/3.1.-.- EchoBASE EB2948 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2948 EcoGene EG13154 http://www.ecogene.org/geneInfo.php?eg_id=EG13154 EnsemblBacteria AAC73329 http://www.ensemblgenomes.org/id/AAC73329 EnsemblBacteria AAC73329 http://www.ensemblgenomes.org/id/AAC73329 EnsemblBacteria BAA77895 http://www.ensemblgenomes.org/id/BAA77895 EnsemblBacteria BAA77895 http://www.ensemblgenomes.org/id/BAA77895 EnsemblBacteria BAA77895 http://www.ensemblgenomes.org/id/BAA77895 EnsemblBacteria b0225 http://www.ensemblgenomes.org/id/b0225 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0004521 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004521 GO_function GO:0016892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016892 GO_function GO:0043022 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043022 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GO_process GO:0006402 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006402 GO_process GO:0006415 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006415 GO_process GO:0044010 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044010 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 GeneID 944911 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944911 HOGENOM HOG000062216 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000062216&db=HOGENOM6 InParanoid Q47149 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q47149 IntAct Q47149 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q47149* IntEnz 3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1 InterPro IPR004386 http://www.ebi.ac.uk/interpro/entry/IPR004386 InterPro IPR007712 http://www.ebi.ac.uk/interpro/entry/IPR007712 KEGG_Gene ecj:JW0215 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0215 KEGG_Gene eco:b0225 http://www.genome.jp/dbget-bin/www_bget?eco:b0225 MINT MINT-1263057 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1263057 OMA HRECHIQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HRECHIQ PDB 4ML2 http://www.ebi.ac.uk/pdbe-srv/view/entry/4ML2 PDB 4MMG http://www.ebi.ac.uk/pdbe-srv/view/entry/4MMG PDB 4Q2U http://www.ebi.ac.uk/pdbe-srv/view/entry/4Q2U PDBsum 4ML2 http://www.ebi.ac.uk/pdbsum/4ML2 PDBsum 4MMG http://www.ebi.ac.uk/pdbsum/4MMG PDBsum 4Q2U http://www.ebi.ac.uk/pdbsum/4Q2U PSORT swissprot:YAFQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAFQ_ECOLI PSORT-B swissprot:YAFQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAFQ_ECOLI PSORT2 swissprot:YAFQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAFQ_ECOLI Pfam PF15738 http://pfam.xfam.org/family/PF15738 Phobius swissprot:YAFQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAFQ_ECOLI PhylomeDB Q47149 http://phylomedb.org/?seqid=Q47149 ProteinModelPortal Q47149 http://www.proteinmodelportal.org/query/uniprot/Q47149 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17263853 http://www.ncbi.nlm.nih.gov/pubmed/17263853 PubMed 19210620 http://www.ncbi.nlm.nih.gov/pubmed/19210620 PubMed 19307375 http://www.ncbi.nlm.nih.gov/pubmed/19307375 PubMed 19707553 http://www.ncbi.nlm.nih.gov/pubmed/19707553 PubMed 7596361 http://www.ncbi.nlm.nih.gov/pubmed/7596361 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414760 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414760 RefSeq WP_000615983 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000615983 SMR Q47149 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q47149 STRING 511145.b0225 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0225&targetmode=cogs TIGRFAMs TIGR00053 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00053 TIGRFAMs TIGR02385 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02385 UniProtKB YAFQ_ECOLI http://www.uniprot.org/uniprot/YAFQ_ECOLI UniProtKB-AC Q47149 http://www.uniprot.org/uniprot/Q47149 charge swissprot:YAFQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAFQ_ECOLI eggNOG COG3041 http://eggnogapi.embl.de/nog_data/html/tree/COG3041 eggNOG ENOG4105VXN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VXN epestfind swissprot:YAFQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAFQ_ECOLI garnier swissprot:YAFQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAFQ_ECOLI helixturnhelix swissprot:YAFQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAFQ_ECOLI hmoment swissprot:YAFQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAFQ_ECOLI iep swissprot:YAFQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAFQ_ECOLI inforesidue swissprot:YAFQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAFQ_ECOLI octanol swissprot:YAFQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAFQ_ECOLI pepcoil swissprot:YAFQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAFQ_ECOLI pepdigest swissprot:YAFQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAFQ_ECOLI pepinfo swissprot:YAFQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAFQ_ECOLI pepnet swissprot:YAFQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAFQ_ECOLI pepstats swissprot:YAFQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAFQ_ECOLI pepwheel swissprot:YAFQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAFQ_ECOLI pepwindow swissprot:YAFQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAFQ_ECOLI sigcleave swissprot:YAFQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAFQ_ECOLI ## Database ID URL or Descriptions # AltName HIS8_ECOLI Imidazole acetol-phosphate transaminase # BRENDA 2.6.1 2026 # BioGrid 4260404 14 # CATALYTIC ACTIVITY L-histidinol phosphate + 2-oxoglutarate = 3- (imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. {ECO:0000269|PubMed 2999081}. # COFACTOR HIS8_ECOLI Name=pyridoxal 5'-phosphate; Xref=ChEBI CHEBI 597326; Evidence={ECO 0000269|PubMed 11294630, ECO 0000269|PubMed 11518529}; # EcoGene EG10446 hisC # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004400 histidinol-phosphate transaminase activity; IDA:EcoCyc. # GO_function GO:0030170 pyridoxal phosphate binding; IEA:InterPro. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function HIS8_ECOLI GO 0080130 L-phenylalanine 2-oxoglutarate aminotransferase activity; IEA UniProtKB-EC. # GO_process GO:0000105 histidine biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.40.640.10 -; 1. # Gene3D 3.90.1150.10 -; 1. # HAMAP MF_01023 HisC_aminotrans_2 # IntAct P06986 5 # InterPro IPR001917 Aminotrans_II_pyridoxalP_BS # InterPro IPR004839 Aminotransferase_I/II # InterPro IPR005861 HisP_aminotrans # InterPro IPR015421 PyrdxlP-dep_Trfase_major_sub1 # InterPro IPR015422 PyrdxlP-dep_Trfase_major_sub2 # InterPro IPR015424 PyrdxlP-dep_Trfase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01007 Amino acid related enzymes # KEGG_Pathway ko00340 Histidine metabolism # KEGG_Pathway ko00350 Tyrosine metabolism # KEGG_Pathway ko00360 Phenylalanine metabolism # KEGG_Pathway ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis # KEGG_Pathway ko00401 Novobiocin biosynthesis # KEGG_Pathway ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis # Organism HIS8_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid biosynthesis; L-histidine biosynthesis; L- histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. {ECO 0000269|PubMed:2999081}. # PATRIC 32119377 VBIEscCol129921_2098 # PDB 1FG3 X-ray; 2.20 A; A=1-356 # PDB 1FG7 X-ray; 1.50 A; A=1-356 # PDB 1GEW X-ray; 2.00 A; A=1-356 # PDB 1GEX X-ray; 2.20 A; A=1-356 # PDB 1GEY X-ray; 2.30 A; A=1-356 # PDB 1IJI X-ray; 2.20 A; A=1-356 # PIR D64967 XNECHC # PROSITE PS00599 AA_TRANSFER_CLASS_2 # Pfam PF00155 Aminotran_1_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HIS8_ECOLI Histidinol-phosphate aminotransferase # RefSeq NP_416525 NC_000913.3 # RefSeq WP_000108941 NZ_LN832404.1 # SIMILARITY Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. {ECO 0000305}. # SUBUNIT HIS8_ECOLI Homodimer. {ECO 0000269|PubMed 11294630, ECO 0000269|PubMed 11518529}. # SUPFAM SSF53383 SSF53383 # TIGRFAMs TIGR01141 hisC # UniPathway UPA00031 UER00012 # eggNOG COG0079 LUCA # eggNOG ENOG4105CIH Bacteria BLAST swissprot:HIS8_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HIS8_ECOLI BioCyc ECOL316407:JW2003-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2003-MONOMER BioCyc EcoCyc:HISTPHOSTRANS-MONOMER http://biocyc.org/getid?id=EcoCyc:HISTPHOSTRANS-MONOMER BioCyc MetaCyc:HISTPHOSTRANS-MONOMER http://biocyc.org/getid?id=MetaCyc:HISTPHOSTRANS-MONOMER COG COG0079 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0079 DIP DIP-9902N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9902N DOI 10.1006/jmbi.1994.1384 http://dx.doi.org/10.1006/jmbi.1994.1384 DOI 10.1006/jmbi.2001.4882 http://dx.doi.org/10.1006/jmbi.2001.4882 DOI 10.1016/0022-2836(88)90194-5 http://dx.doi.org/10.1016/0022-2836(88)90194-5 DOI 10.1021/bi002769u http://dx.doi.org/10.1021/bi002769u DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.6.1.9 http://www.genome.jp/dbget-bin/www_bget?EC:2.6.1.9 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U02071 http://www.ebi.ac.uk/ena/data/view/U02071 EMBL X03416 http://www.ebi.ac.uk/ena/data/view/X03416 EMBL X13462 http://www.ebi.ac.uk/ena/data/view/X13462 ENZYME 2.6.1.9 http://enzyme.expasy.org/EC/2.6.1.9 EchoBASE EB0441 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0441 EcoGene EG10446 http://www.ecogene.org/geneInfo.php?eg_id=EG10446 EnsemblBacteria AAC75082 http://www.ensemblgenomes.org/id/AAC75082 EnsemblBacteria AAC75082 http://www.ensemblgenomes.org/id/AAC75082 EnsemblBacteria BAA15852 http://www.ensemblgenomes.org/id/BAA15852 EnsemblBacteria BAA15852 http://www.ensemblgenomes.org/id/BAA15852 EnsemblBacteria BAA15852 http://www.ensemblgenomes.org/id/BAA15852 EnsemblBacteria b2021 http://www.ensemblgenomes.org/id/b2021 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004400 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004400 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0080130 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0080130 GO_process GO:0000105 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000105 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.40.640.10 http://www.cathdb.info/version/latest/superfamily/3.40.640.10 Gene3D 3.90.1150.10 http://www.cathdb.info/version/latest/superfamily/3.90.1150.10 GeneID 946551 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946551 HAMAP MF_01023 http://hamap.expasy.org/unirule/MF_01023 HOGENOM HOG000288512 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000288512&db=HOGENOM6 InParanoid P06986 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P06986 IntAct P06986 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P06986* IntEnz 2.6.1.9 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.6.1.9 InterPro IPR001917 http://www.ebi.ac.uk/interpro/entry/IPR001917 InterPro IPR004839 http://www.ebi.ac.uk/interpro/entry/IPR004839 InterPro IPR005861 http://www.ebi.ac.uk/interpro/entry/IPR005861 InterPro IPR015421 http://www.ebi.ac.uk/interpro/entry/IPR015421 InterPro IPR015422 http://www.ebi.ac.uk/interpro/entry/IPR015422 InterPro IPR015424 http://www.ebi.ac.uk/interpro/entry/IPR015424 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Gene ecj:JW2003 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2003 KEGG_Gene eco:b2021 http://www.genome.jp/dbget-bin/www_bget?eco:b2021 KEGG_Orthology KO:K00817 http://www.genome.jp/dbget-bin/www_bget?KO:K00817 KEGG_Pathway ko00340 http://www.genome.jp/kegg-bin/show_pathway?ko00340 KEGG_Pathway ko00350 http://www.genome.jp/kegg-bin/show_pathway?ko00350 KEGG_Pathway ko00360 http://www.genome.jp/kegg-bin/show_pathway?ko00360 KEGG_Pathway ko00400 http://www.genome.jp/kegg-bin/show_pathway?ko00400 KEGG_Pathway ko00401 http://www.genome.jp/kegg-bin/show_pathway?ko00401 KEGG_Pathway ko00960 http://www.genome.jp/kegg-bin/show_pathway?ko00960 KEGG_Reaction rn:R00694 http://www.genome.jp/dbget-bin/www_bget?rn:R00694 KEGG_Reaction rn:R00734 http://www.genome.jp/dbget-bin/www_bget?rn:R00734 KEGG_Reaction rn:R03243 http://www.genome.jp/dbget-bin/www_bget?rn:R03243 MINT MINT-1322565 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1322565 OMA YPSEANY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YPSEANY PDB 1FG3 http://www.ebi.ac.uk/pdbe-srv/view/entry/1FG3 PDB 1FG7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1FG7 PDB 1GEW http://www.ebi.ac.uk/pdbe-srv/view/entry/1GEW PDB 1GEX http://www.ebi.ac.uk/pdbe-srv/view/entry/1GEX PDB 1GEY http://www.ebi.ac.uk/pdbe-srv/view/entry/1GEY PDB 1IJI http://www.ebi.ac.uk/pdbe-srv/view/entry/1IJI PDBsum 1FG3 http://www.ebi.ac.uk/pdbsum/1FG3 PDBsum 1FG7 http://www.ebi.ac.uk/pdbsum/1FG7 PDBsum 1GEW http://www.ebi.ac.uk/pdbsum/1GEW PDBsum 1GEX http://www.ebi.ac.uk/pdbsum/1GEX PDBsum 1GEY http://www.ebi.ac.uk/pdbsum/1GEY PDBsum 1IJI http://www.ebi.ac.uk/pdbsum/1IJI PROSITE PS00599 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00599 PSORT swissprot:HIS8_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HIS8_ECOLI PSORT-B swissprot:HIS8_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HIS8_ECOLI PSORT2 swissprot:HIS8_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HIS8_ECOLI Pfam PF00155 http://pfam.xfam.org/family/PF00155 Phobius swissprot:HIS8_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HIS8_ECOLI PhylomeDB P06986 http://phylomedb.org/?seqid=P06986 ProteinModelPortal P06986 http://www.proteinmodelportal.org/query/uniprot/P06986 PubMed 11294630 http://www.ncbi.nlm.nih.gov/pubmed/11294630 PubMed 11518529 http://www.ncbi.nlm.nih.gov/pubmed/11518529 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2999081 http://www.ncbi.nlm.nih.gov/pubmed/2999081 PubMed 3062174 http://www.ncbi.nlm.nih.gov/pubmed/3062174 PubMed 8201624 http://www.ncbi.nlm.nih.gov/pubmed/8201624 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416525 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416525 RefSeq WP_000108941 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000108941 SMR P06986 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P06986 STRING 511145.b2021 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2021&targetmode=cogs STRING COG0079 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0079&targetmode=cogs SUPFAM SSF53383 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53383 TIGRFAMs TIGR01141 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01141 UniProtKB HIS8_ECOLI http://www.uniprot.org/uniprot/HIS8_ECOLI UniProtKB-AC P06986 http://www.uniprot.org/uniprot/P06986 charge swissprot:HIS8_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HIS8_ECOLI eggNOG COG0079 http://eggnogapi.embl.de/nog_data/html/tree/COG0079 eggNOG ENOG4105CIH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CIH epestfind swissprot:HIS8_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HIS8_ECOLI garnier swissprot:HIS8_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HIS8_ECOLI helixturnhelix swissprot:HIS8_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HIS8_ECOLI hmoment swissprot:HIS8_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HIS8_ECOLI iep swissprot:HIS8_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HIS8_ECOLI inforesidue swissprot:HIS8_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HIS8_ECOLI octanol swissprot:HIS8_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HIS8_ECOLI pepcoil swissprot:HIS8_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HIS8_ECOLI pepdigest swissprot:HIS8_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HIS8_ECOLI pepinfo swissprot:HIS8_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HIS8_ECOLI pepnet swissprot:HIS8_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HIS8_ECOLI pepstats swissprot:HIS8_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HIS8_ECOLI pepwheel swissprot:HIS8_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HIS8_ECOLI pepwindow swissprot:HIS8_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HIS8_ECOLI sigcleave swissprot:HIS8_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HIS8_ECOLI ## Database ID URL or Descriptions # BioGrid 4261893 194 # CATALYTIC ACTIVITY RFAJ_ECOLI UDP-glucose + [lipopolysaccharide] = UDP + D- glucosyl-[lipopolysaccharide]. # CAZy GT8 Glycosyltransferase Family 8 # EcoGene EG11353 rfaJ # FUNCTION RFAJ_ECOLI Adds the glucose(II) group on the galactose(I) group of LPS. {ECO 0000250|UniProtKB P19817}. # GO_function GO:0008918 lipopolysaccharide 3-alpha-galactosyltransferase activity; IEA:InterPro. # GO_function GO:0008919 lipopolysaccharide glucosyltransferase I activity; IDA:EcoCyc. # GO_process GO:0009244 lipopolysaccharide core region biosynthetic process; IMP:EcoCyc. # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.90.550.10 -; 1. # IntAct P27129 6 # InterPro IPR002495 Glyco_trans_8 # InterPro IPR013645 Glyco_transf_8N # InterPro IPR029044 Nucleotide-diphossugar_trans # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01003 Glycosyltransferases # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # KEGG_Pathway ko00540 Lipopolysaccharide biosynthesis # Organism RFAJ_ECOLI Escherichia coli (strain K12) # PATHWAY RFAJ_ECOLI Bacterial outer membrane biogenesis; LPS core biosynthesis. # PATRIC 32122739 VBIEscCol129921_3746 # PIR S47847 S47847 # Pfam PF01501 Glyco_transf_8 # Pfam PF08437 Glyco_transf_8C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RFAJ_ECOLI Lipopolysaccharide 1,2-glucosyltransferase # RefSeq NP_418083 NC_000913.3 # RefSeq WP_000376841 NZ_LN832404.1 # SIMILARITY Belongs to the glycosyltransferase 8 family. {ECO 0000305}. # SUPFAM SSF53448 SSF53448 # eggNOG COG1442 LUCA # eggNOG ENOG4105X1N Bacteria BLAST swissprot:RFAJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RFAJ_ECOLI BioCyc ECOL316407:JW3601-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3601-MONOMER BioCyc EcoCyc:EG11353-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11353-MONOMER BioCyc MetaCyc:EG11353-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11353-MONOMER COG CAZy: http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=CAZy: COG COG1442 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1442 COG GT8 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=GT8 DIP DIP-10671N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10671N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.4.1.58 http://www.genome.jp/dbget-bin/www_bget?EC:2.4.1.58 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M80599 http://www.ebi.ac.uk/ena/data/view/M80599 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.4.1.58 http://enzyme.expasy.org/EC/2.4.1.58 EchoBASE EB1328 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1328 EcoGene EG11353 http://www.ecogene.org/geneInfo.php?eg_id=EG11353 EnsemblBacteria AAC76650 http://www.ensemblgenomes.org/id/AAC76650 EnsemblBacteria AAC76650 http://www.ensemblgenomes.org/id/AAC76650 EnsemblBacteria BAE77666 http://www.ensemblgenomes.org/id/BAE77666 EnsemblBacteria BAE77666 http://www.ensemblgenomes.org/id/BAE77666 EnsemblBacteria BAE77666 http://www.ensemblgenomes.org/id/BAE77666 EnsemblBacteria b3626 http://www.ensemblgenomes.org/id/b3626 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008918 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008918 GO_function GO:0008919 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008919 GO_process GO:0009244 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009244 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.90.550.10 http://www.cathdb.info/version/latest/superfamily/3.90.550.10 GeneID 948142 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948142 HOGENOM HOG000126190 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126190&db=HOGENOM6 InParanoid P27129 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P27129 IntAct P27129 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P27129* IntEnz 2.4.1.58 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.1.58 InterPro IPR002495 http://www.ebi.ac.uk/interpro/entry/IPR002495 InterPro IPR013645 http://www.ebi.ac.uk/interpro/entry/IPR013645 InterPro IPR029044 http://www.ebi.ac.uk/interpro/entry/IPR029044 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01003 http://www.genome.jp/dbget-bin/www_bget?ko01003 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Gene ecj:JW3601 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3601 KEGG_Gene eco:b3626 http://www.genome.jp/dbget-bin/www_bget?eco:b3626 KEGG_Orthology KO:K03276 http://www.genome.jp/dbget-bin/www_bget?KO:K03276 KEGG_Pathway ko00540 http://www.genome.jp/kegg-bin/show_pathway?ko00540 KEGG_Reaction rn:R01994 http://www.genome.jp/dbget-bin/www_bget?rn:R01994 MINT MINT-1248317 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1248317 OMA TVILHFC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TVILHFC PSORT swissprot:RFAJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RFAJ_ECOLI PSORT-B swissprot:RFAJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RFAJ_ECOLI PSORT2 swissprot:RFAJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RFAJ_ECOLI Pfam PF01501 http://pfam.xfam.org/family/PF01501 Pfam PF08437 http://pfam.xfam.org/family/PF08437 Phobius swissprot:RFAJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RFAJ_ECOLI PhylomeDB P27129 http://phylomedb.org/?seqid=P27129 ProteinModelPortal P27129 http://www.proteinmodelportal.org/query/uniprot/P27129 PubMed 1624461 http://www.ncbi.nlm.nih.gov/pubmed/1624461 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418083 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418083 RefSeq WP_000376841 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000376841 STRING 511145.b3626 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3626&targetmode=cogs STRING CAZy: http://string-db.org/newstring_cgi/show_network_section.pl?identifier=CAZy:&targetmode=cogs STRING COG1442 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1442&targetmode=cogs STRING GT8 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=GT8&targetmode=cogs SUPFAM SSF53448 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53448 UniProtKB RFAJ_ECOLI http://www.uniprot.org/uniprot/RFAJ_ECOLI UniProtKB-AC P27129 http://www.uniprot.org/uniprot/P27129 charge swissprot:RFAJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RFAJ_ECOLI eggNOG COG1442 http://eggnogapi.embl.de/nog_data/html/tree/COG1442 eggNOG ENOG4105X1N http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105X1N epestfind swissprot:RFAJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RFAJ_ECOLI garnier swissprot:RFAJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RFAJ_ECOLI helixturnhelix swissprot:RFAJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RFAJ_ECOLI hmoment swissprot:RFAJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RFAJ_ECOLI iep swissprot:RFAJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RFAJ_ECOLI inforesidue swissprot:RFAJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RFAJ_ECOLI octanol swissprot:RFAJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RFAJ_ECOLI pepcoil swissprot:RFAJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RFAJ_ECOLI pepdigest swissprot:RFAJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RFAJ_ECOLI pepinfo swissprot:RFAJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RFAJ_ECOLI pepnet swissprot:RFAJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RFAJ_ECOLI pepstats swissprot:RFAJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RFAJ_ECOLI pepwheel swissprot:RFAJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RFAJ_ECOLI pepwindow swissprot:RFAJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RFAJ_ECOLI sigcleave swissprot:RFAJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RFAJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4262223 10 # EcoGene EG12062 napH # FUNCTION NAPH_ECOLI Involved in electron transfer. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:EcoliWiki. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005506 iron ion binding; IEA:InterPro. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0055114 oxidation-reduction process; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # IntAct P33934 2 # InterPro IPR011886 NapH_MauN # InterPro IPR017896 4Fe4S_Fe-S-bd # InterPro IPR017900 4Fe4S_Fe_S_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko00910 Nitrogen metabolism # Organism NAPH_ECOLI Escherichia coli (strain K12) # PATRIC 32119767 VBIEscCol129921_2293 # PIR B64990 B64990 # PROSITE PS00198 4FE4S_FER_1 # PROSITE PS51379 4FE4S_FER_2; 2 # Pfam PF12801 Fer4_5; 2 # Pfam PF13237 Fer4_10 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NAPH_ECOLI Ferredoxin-type protein NapH # RefSeq NP_416708 NC_000913.3 # RefSeq WP_000013515 NZ_LN832404.1 # SIMILARITY Contains 2 4Fe-4S ferredoxin-type domains. {ECO:0000255|PROSITE-ProRule PRU00711}. # SUBCELLULAR LOCATION NAPH_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # TIGRFAMs TIGR02163 napH_ # eggNOG COG0348 LUCA # eggNOG ENOG4105GXZ Bacteria BLAST swissprot:NAPH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NAPH_ECOLI BioCyc ECOL316407:JW2192-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2192-MONOMER BioCyc EcoCyc:NAPH-MONOMER http://biocyc.org/getid?id=EcoCyc:NAPH-MONOMER BioCyc MetaCyc:NAPH-MONOMER http://biocyc.org/getid?id=MetaCyc:NAPH-MONOMER COG COG0348 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0348 DIP DIP-10310N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10310N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00008 http://www.ebi.ac.uk/ena/data/view/U00008 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1992 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1992 EcoGene EG12062 http://www.ecogene.org/geneInfo.php?eg_id=EG12062 EnsemblBacteria AAC75264 http://www.ensemblgenomes.org/id/AAC75264 EnsemblBacteria AAC75264 http://www.ensemblgenomes.org/id/AAC75264 EnsemblBacteria BAE76667 http://www.ensemblgenomes.org/id/BAE76667 EnsemblBacteria BAE76667 http://www.ensemblgenomes.org/id/BAE76667 EnsemblBacteria BAE76667 http://www.ensemblgenomes.org/id/BAE76667 EnsemblBacteria b2204 http://www.ensemblgenomes.org/id/b2204 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0055114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 945984 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945984 HOGENOM HOG000275510 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275510&db=HOGENOM6 InParanoid P33934 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33934 IntAct P33934 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33934* InterPro IPR011886 http://www.ebi.ac.uk/interpro/entry/IPR011886 InterPro IPR017896 http://www.ebi.ac.uk/interpro/entry/IPR017896 InterPro IPR017900 http://www.ebi.ac.uk/interpro/entry/IPR017900 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW2192 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2192 KEGG_Gene eco:b2204 http://www.genome.jp/dbget-bin/www_bget?eco:b2204 KEGG_Orthology KO:K02574 http://www.genome.jp/dbget-bin/www_bget?KO:K02574 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Reaction rn:R00798 http://www.genome.jp/dbget-bin/www_bget?rn:R00798 MINT MINT-1276100 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1276100 OMA CPVGAFY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CPVGAFY PROSITE PS00198 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00198 PROSITE PS51379 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51379 PSORT swissprot:NAPH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NAPH_ECOLI PSORT-B swissprot:NAPH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NAPH_ECOLI PSORT2 swissprot:NAPH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NAPH_ECOLI Pfam PF12801 http://pfam.xfam.org/family/PF12801 Pfam PF13237 http://pfam.xfam.org/family/PF13237 Phobius swissprot:NAPH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NAPH_ECOLI PhylomeDB P33934 http://phylomedb.org/?seqid=P33934 ProteinModelPortal P33934 http://www.proteinmodelportal.org/query/uniprot/P33934 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416708 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416708 RefSeq WP_000013515 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000013515 STRING 511145.b2204 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2204&targetmode=cogs STRING COG0348 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0348&targetmode=cogs TIGRFAMs TIGR02163 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02163 UniProtKB NAPH_ECOLI http://www.uniprot.org/uniprot/NAPH_ECOLI UniProtKB-AC P33934 http://www.uniprot.org/uniprot/P33934 charge swissprot:NAPH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NAPH_ECOLI eggNOG COG0348 http://eggnogapi.embl.de/nog_data/html/tree/COG0348 eggNOG ENOG4105GXZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105GXZ epestfind swissprot:NAPH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NAPH_ECOLI garnier swissprot:NAPH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NAPH_ECOLI helixturnhelix swissprot:NAPH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NAPH_ECOLI hmoment swissprot:NAPH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NAPH_ECOLI iep swissprot:NAPH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NAPH_ECOLI inforesidue swissprot:NAPH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NAPH_ECOLI octanol swissprot:NAPH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NAPH_ECOLI pepcoil swissprot:NAPH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NAPH_ECOLI pepdigest swissprot:NAPH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NAPH_ECOLI pepinfo swissprot:NAPH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NAPH_ECOLI pepnet swissprot:NAPH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NAPH_ECOLI pepstats swissprot:NAPH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NAPH_ECOLI pepwheel swissprot:NAPH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NAPH_ECOLI pepwindow swissprot:NAPH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NAPH_ECOLI sigcleave swissprot:NAPH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NAPH_ECOLI ## Database ID URL or Descriptions # AltName LYSQ_ECOLI Endolysin # AltName LYSQ_ECOLI Lysis protein # AltName LYSQ_ECOLI Muramidase # AltName LYSQ_ECOLI Probable lysozyme from lambdoid prophage Qin # BioGrid 4259501 5 # CATALYTIC ACTIVITY LYSQ_ECOLI Hydrolysis of (1->4)-beta-linkages between N- acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. # CDD cd00737 endolysin_autolysin # EcoGene EG13829 rrrQ # FUNCTION LYSQ_ECOLI Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity. {ECO 0000250}. # GO_function GO:0003796 lysozyme activity; IEA:UniProtKB-EC. # GO_process GO:0009253 peptidoglycan catabolic process; IEA:InterPro. # GO_process GO:0016998 cell wall macromolecule catabolic process; IEA:InterPro. # GO_process GO:0042742 defense response to bacterium; IEA:UniProtKB-KW. # GO_process GO:0044659 cytolysis by virus of host cell; IEA:InterPro. # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0040011 locomotion # GOslim_process GO:0044403 symbiosis, encompassing mutualism through parasitism # Gene3D 1.10.530.40 -; 1. # IntAct P76159 2 # InterPro IPR002196 Glyco_hydro_24 # InterPro IPR023346 Lysozyme-like_dom # InterPro IPR023347 Lysozyme_dom # InterPro IPR033907 Endolysin_autolysin # KEGG_Brite ko01000 Enzymes # Organism LYSQ_ECOLI Escherichia coli (strain K12) # PATRIC 32118410 VBIEscCol129921_1625 # PIR E64910 E64910 # Pfam PF00959 Phage_lysozyme # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Probable prophage lysozyme {ECO 0000305} # RefSeq NP_416072 NC_000913.3 # RefSeq WP_001092971 NZ_LN832404.1 # SIMILARITY Belongs to the glycosyl hydrolase 24 family. {ECO 0000305}. # SUPFAM SSF53955 SSF53955 # eggNOG COG3772 LUCA BLAST swissprot:LYSQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LYSQ_ECOLI BioCyc ECOL316407:JW1546-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1546-MONOMER BioCyc EcoCyc:G6827-MONOMER http://biocyc.org/getid?id=EcoCyc:G6827-MONOMER COG COG3772 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3772 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.2.1.17 http://www.genome.jp/dbget-bin/www_bget?EC:3.2.1.17 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.2.1.17 http://enzyme.expasy.org/EC/3.2.1.17 EchoBASE EB3590 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3590 EcoGene EG13829 http://www.ecogene.org/geneInfo.php?eg_id=EG13829 EnsemblBacteria AAC74627 http://www.ensemblgenomes.org/id/AAC74627 EnsemblBacteria AAC74627 http://www.ensemblgenomes.org/id/AAC74627 EnsemblBacteria BAE76469 http://www.ensemblgenomes.org/id/BAE76469 EnsemblBacteria BAE76469 http://www.ensemblgenomes.org/id/BAE76469 EnsemblBacteria BAE76469 http://www.ensemblgenomes.org/id/BAE76469 EnsemblBacteria b1554 http://www.ensemblgenomes.org/id/b1554 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003796 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003796 GO_process GO:0009253 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009253 GO_process GO:0016998 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016998 GO_process GO:0042742 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042742 GO_process GO:0044659 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044659 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0040011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011 GOslim_process GO:0044403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403 Gene3D 1.10.530.40 http://www.cathdb.info/version/latest/superfamily/1.10.530.40 GeneID 946100 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946100 HOGENOM HOG000277067 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000277067&db=HOGENOM6 InParanoid P76159 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76159 IntAct P76159 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76159* IntEnz 3.2.1.17 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.2.1.17 InterPro IPR002196 http://www.ebi.ac.uk/interpro/entry/IPR002196 InterPro IPR023346 http://www.ebi.ac.uk/interpro/entry/IPR023346 InterPro IPR023347 http://www.ebi.ac.uk/interpro/entry/IPR023347 InterPro IPR033907 http://www.ebi.ac.uk/interpro/entry/IPR033907 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1546 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1546 KEGG_Gene eco:b1554 http://www.genome.jp/dbget-bin/www_bget?eco:b1554 KEGG_Orthology KO:K01185 http://www.genome.jp/dbget-bin/www_bget?KO:K01185 OMA KDCRIRS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KDCRIRS PSORT swissprot:LYSQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LYSQ_ECOLI PSORT-B swissprot:LYSQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LYSQ_ECOLI PSORT2 swissprot:LYSQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LYSQ_ECOLI Pfam PF00959 http://pfam.xfam.org/family/PF00959 Phobius swissprot:LYSQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LYSQ_ECOLI PhylomeDB P76159 http://phylomedb.org/?seqid=P76159 ProteinModelPortal P76159 http://www.proteinmodelportal.org/query/uniprot/P76159 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416072 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416072 RefSeq WP_001092971 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001092971 SMR P76159 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76159 STRING 511145.b1554 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1554&targetmode=cogs STRING COG3772 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3772&targetmode=cogs SUPFAM SSF53955 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53955 UniProtKB LYSQ_ECOLI http://www.uniprot.org/uniprot/LYSQ_ECOLI UniProtKB-AC P76159 http://www.uniprot.org/uniprot/P76159 charge swissprot:LYSQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LYSQ_ECOLI eggNOG COG3772 http://eggnogapi.embl.de/nog_data/html/tree/COG3772 epestfind swissprot:LYSQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LYSQ_ECOLI garnier swissprot:LYSQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LYSQ_ECOLI helixturnhelix swissprot:LYSQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LYSQ_ECOLI hmoment swissprot:LYSQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LYSQ_ECOLI iep swissprot:LYSQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LYSQ_ECOLI inforesidue swissprot:LYSQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LYSQ_ECOLI octanol swissprot:LYSQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LYSQ_ECOLI pepcoil swissprot:LYSQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LYSQ_ECOLI pepdigest swissprot:LYSQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LYSQ_ECOLI pepinfo swissprot:LYSQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LYSQ_ECOLI pepnet swissprot:LYSQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LYSQ_ECOLI pepstats swissprot:LYSQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LYSQ_ECOLI pepwheel swissprot:LYSQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LYSQ_ECOLI pepwindow swissprot:LYSQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LYSQ_ECOLI sigcleave swissprot:LYSQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LYSQ_ECOLI ## Database ID URL or Descriptions # AltName CSPA_ECOLI 7.4 kDa cold shock protein # AltName CSPA_ECOLI CS7.4 # BioGrid 4262533 8 # CDD cd04458 CSP_CDS # EcoGene EG10166 cspA # FUNCTION CSPA_ECOLI Binds to and stimulates the transcription of the CCAAT- containing, cold-shock-inducible promoters of the H-NS and GyrA proteins. Binds also to the inverted repeat 5'-ATTGG-3'. {ECO 0000269|PubMed 1961761}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0001072 transcription antitermination factor activity, RNA binding; IDA:EcoliWiki. # GO_function GO:0003677 DNA binding; IDA:EcoliWiki. # GO_function GO:0003697 single-stranded DNA binding; IDA:EcoliWiki. # GO_function GO:0003723 RNA binding; IDA:EcoliWiki. # GO_function GO:0003727 single-stranded RNA binding; IDA:EcoliWiki. # GO_process GO:0006351 transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0009409 response to cold; IEP:EcoliWiki. # GO_process GO:0045893 positive regulation of transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0060567 negative regulation of DNA-templated transcription, termination; IDA:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0003723 RNA binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # INDUCTION CSPA_ECOLI In response to low temperature. # IntAct P0A9X9 42 # InterPro IPR002059 CSP_DNA-bd # InterPro IPR011129 Cold_shock_prot # InterPro IPR012156 Cold_shock_CspA # InterPro IPR012340 NA-bd_OB-fold # InterPro IPR019844 Cold-shock_CS # KEGG_Brite ko03000 Transcription factors # Organism CSPA_ECOLI Escherichia coli (strain K12) # PATRIC 32122584 VBIEscCol129921_3669 # PDB 1MJC X-ray; 2.00 A; A=2-70 # PDB 2BH8 X-ray; 1.90 A; A/B=2-36 # PDB 2L15 NMR; -; A=1-70 # PDB 3MEF NMR; -; A=2-70 # PIR JH0201 OCECJ # PIRSF PIRSF002599 Cold_shock_A # PRINTS PR00050 COLDSHOCK # PROSITE PS00352 COLD_SHOCK # Pfam PF00313 CSD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CSPA_ECOLI Cold shock protein CspA # RefSeq NP_418012 NC_000913.3 # RefSeq WP_000014594 NZ_LN832404.1 # SIMILARITY Contains 1 CSD (cold-shock) domain. {ECO 0000305}. # SMART SM00357 CSP # SUBCELLULAR LOCATION CSPA_ECOLI Cytoplasm. # SUPFAM SSF50249 SSF50249 # eggNOG COG1278 LUCA BLAST swissprot:CSPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CSPA_ECOLI BioCyc ECOL316407:JW3525-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3525-MONOMER BioCyc EcoCyc:PD03695 http://biocyc.org/getid?id=EcoCyc:PD03695 COG COG1278 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1278 DIP DIP-31862N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-31862N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1021/bi980269j http://dx.doi.org/10.1021/bi980269j DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/sj.jim.2900463 http://dx.doi.org/10.1038/sj.jim.2900463 DOI 10.1073/pnas.87.1.283 http://dx.doi.org/10.1073/pnas.87.1.283 DOI 10.1073/pnas.88.23.10907 http://dx.doi.org/10.1073/pnas.88.23.10907 DOI 10.1073/pnas.91.11.5114 http://dx.doi.org/10.1073/pnas.91.11.5114 DOI 10.1073/pnas.91.11.5119 http://dx.doi.org/10.1073/pnas.91.11.5119 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M30139 http://www.ebi.ac.uk/ena/data/view/M30139 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U60035 http://www.ebi.ac.uk/ena/data/view/U60035 EchoBASE EB0164 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0164 EcoGene EG10166 http://www.ecogene.org/geneInfo.php?eg_id=EG10166 EnsemblBacteria AAC76580 http://www.ensemblgenomes.org/id/AAC76580 EnsemblBacteria AAC76580 http://www.ensemblgenomes.org/id/AAC76580 EnsemblBacteria BAE77739 http://www.ensemblgenomes.org/id/BAE77739 EnsemblBacteria BAE77739 http://www.ensemblgenomes.org/id/BAE77739 EnsemblBacteria BAE77739 http://www.ensemblgenomes.org/id/BAE77739 EnsemblBacteria b3556 http://www.ensemblgenomes.org/id/b3556 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0001072 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001072 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003697 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003697 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0003727 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003727 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0009409 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009409 GO_process GO:0045893 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045893 GO_process GO:0060567 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060567 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 23335706 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23335706 GeneID 948070 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948070 HOGENOM HOG000070674 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000070674&db=HOGENOM6 InParanoid P0A9X9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9X9 IntAct P0A9X9 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9X9* InterPro IPR002059 http://www.ebi.ac.uk/interpro/entry/IPR002059 InterPro IPR011129 http://www.ebi.ac.uk/interpro/entry/IPR011129 InterPro IPR012156 http://www.ebi.ac.uk/interpro/entry/IPR012156 InterPro IPR012340 http://www.ebi.ac.uk/interpro/entry/IPR012340 InterPro IPR019844 http://www.ebi.ac.uk/interpro/entry/IPR019844 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW3525 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3525 KEGG_Gene eco:b3556 http://www.genome.jp/dbget-bin/www_bget?eco:b3556 KEGG_Orthology KO:K03704 http://www.genome.jp/dbget-bin/www_bget?KO:K03704 MINT MINT-1220153 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1220153 OMA AIQNEGY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AIQNEGY PDB 1MJC http://www.ebi.ac.uk/pdbe-srv/view/entry/1MJC PDB 2BH8 http://www.ebi.ac.uk/pdbe-srv/view/entry/2BH8 PDB 2L15 http://www.ebi.ac.uk/pdbe-srv/view/entry/2L15 PDB 3MEF http://www.ebi.ac.uk/pdbe-srv/view/entry/3MEF PDBsum 1MJC http://www.ebi.ac.uk/pdbsum/1MJC PDBsum 2BH8 http://www.ebi.ac.uk/pdbsum/2BH8 PDBsum 2L15 http://www.ebi.ac.uk/pdbsum/2L15 PDBsum 3MEF http://www.ebi.ac.uk/pdbsum/3MEF PRINTS PR00050 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00050 PROSITE PS00352 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00352 PSORT swissprot:CSPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CSPA_ECOLI PSORT-B swissprot:CSPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CSPA_ECOLI PSORT2 swissprot:CSPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CSPA_ECOLI Pfam PF00313 http://pfam.xfam.org/family/PF00313 Phobius swissprot:CSPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CSPA_ECOLI PhylomeDB P0A9X9 http://phylomedb.org/?seqid=P0A9X9 ProteinModelPortal P0A9X9 http://www.proteinmodelportal.org/query/uniprot/P0A9X9 PubMed 1597410 http://www.ncbi.nlm.nih.gov/pubmed/1597410 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1961761 http://www.ncbi.nlm.nih.gov/pubmed/1961761 PubMed 2404279 http://www.ncbi.nlm.nih.gov/pubmed/2404279 PubMed 7515185 http://www.ncbi.nlm.nih.gov/pubmed/7515185 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 8197194 http://www.ncbi.nlm.nih.gov/pubmed/8197194 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9439003 http://www.ncbi.nlm.nih.gov/pubmed/9439003 PubMed 9692981 http://www.ncbi.nlm.nih.gov/pubmed/9692981 RefSeq NP_418012 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418012 RefSeq WP_000014594 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000014594 SMART SM00357 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00357 SMR P0A9X9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9X9 STRING 511145.b3556 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3556&targetmode=cogs STRING COG1278 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1278&targetmode=cogs SUPFAM SSF50249 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50249 UniProtKB CSPA_ECOLI http://www.uniprot.org/uniprot/CSPA_ECOLI UniProtKB-AC P0A9X9 http://www.uniprot.org/uniprot/P0A9X9 charge swissprot:CSPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CSPA_ECOLI eggNOG COG1278 http://eggnogapi.embl.de/nog_data/html/tree/COG1278 epestfind swissprot:CSPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CSPA_ECOLI garnier swissprot:CSPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CSPA_ECOLI helixturnhelix swissprot:CSPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CSPA_ECOLI hmoment swissprot:CSPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CSPA_ECOLI iep swissprot:CSPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CSPA_ECOLI inforesidue swissprot:CSPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CSPA_ECOLI octanol swissprot:CSPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CSPA_ECOLI pepcoil swissprot:CSPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CSPA_ECOLI pepdigest swissprot:CSPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CSPA_ECOLI pepinfo swissprot:CSPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CSPA_ECOLI pepnet swissprot:CSPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CSPA_ECOLI pepstats swissprot:CSPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CSPA_ECOLI pepwheel swissprot:CSPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CSPA_ECOLI pepwindow swissprot:CSPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CSPA_ECOLI sigcleave swissprot:CSPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CSPA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261094 16 # EcoGene EG12037 yejA # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; ISS:EcoCyc. # GO_function GO:0015197 peptide transporter activity; IBA:GO_Central. # GO_function GO:0043492 ATPase activity, coupled to movement of substances; ISS:EcoCyc. # GO_process GO:0042884 microcin transport; IMP:EcoCyc. # GO_process GO:0055085 transmembrane transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016887 ATPase activity # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # IntAct P33913 2 # InterPro IPR000914 SBP_5_dom # InterPro IPR030678 Peptide/Ni-bd # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00349 Microcin C transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism YEJA_ECOLI Escherichia coli (strain K12) # PATRIC 32119709 VBIEscCol129921_2265 # PIR H64986 H64986 # PIRSF PIRSF002741 MppA # Pfam PF00496 SBP_bac_5 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEJA_ECOLI Uncharacterized protein YejA # RefSeq NP_416682 NC_000913.3 # RefSeq WP_000637046 NZ_LN832404.1 # SIMILARITY To H.influenzae HbpA. {ECO 0000305}. # TCDB 3.A.1.5.21 the atp-binding cassette (abc) superfamily # eggNOG COG4166 LUCA # eggNOG ENOG4105E43 Bacteria BLAST swissprot:YEJA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEJA_ECOLI BioCyc ECOL316407:JW2165-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2165-MONOMER BioCyc EcoCyc:YEJA-MONOMER http://biocyc.org/getid?id=EcoCyc:YEJA-MONOMER COG COG4166 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4166 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00008 http://www.ebi.ac.uk/ena/data/view/U00008 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1972 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1972 EcoGene EG12037 http://www.ecogene.org/geneInfo.php?eg_id=EG12037 EnsemblBacteria AAC75238 http://www.ensemblgenomes.org/id/AAC75238 EnsemblBacteria AAC75238 http://www.ensemblgenomes.org/id/AAC75238 EnsemblBacteria BAA15985 http://www.ensemblgenomes.org/id/BAA15985 EnsemblBacteria BAA15985 http://www.ensemblgenomes.org/id/BAA15985 EnsemblBacteria BAA15985 http://www.ensemblgenomes.org/id/BAA15985 EnsemblBacteria b2177 http://www.ensemblgenomes.org/id/b2177 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0015197 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015197 GO_function GO:0043492 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043492 GO_process GO:0042884 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042884 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 946675 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946675 HOGENOM HOG000260503 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000260503&db=HOGENOM6 InParanoid P33913 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33913 IntAct P33913 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33913* InterPro IPR000914 http://www.ebi.ac.uk/interpro/entry/IPR000914 InterPro IPR030678 http://www.ebi.ac.uk/interpro/entry/IPR030678 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2165 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2165 KEGG_Gene eco:b2177 http://www.genome.jp/dbget-bin/www_bget?eco:b2177 KEGG_Orthology KO:K13893 http://www.genome.jp/dbget-bin/www_bget?KO:K13893 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA PTGMQGF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PTGMQGF PSORT swissprot:YEJA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEJA_ECOLI PSORT-B swissprot:YEJA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEJA_ECOLI PSORT2 swissprot:YEJA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEJA_ECOLI Pfam PF00496 http://pfam.xfam.org/family/PF00496 Phobius swissprot:YEJA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEJA_ECOLI PhylomeDB P33913 http://phylomedb.org/?seqid=P33913 ProteinModelPortal P33913 http://www.proteinmodelportal.org/query/uniprot/P33913 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416682 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416682 RefSeq WP_000637046 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000637046 SMR P33913 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P33913 STRING 511145.b2177 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2177&targetmode=cogs STRING COG4166 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4166&targetmode=cogs TCDB 3.A.1.5.21 http://www.tcdb.org/search/result.php?tc=3.A.1.5.21 UniProtKB YEJA_ECOLI http://www.uniprot.org/uniprot/YEJA_ECOLI UniProtKB-AC P33913 http://www.uniprot.org/uniprot/P33913 charge swissprot:YEJA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEJA_ECOLI eggNOG COG4166 http://eggnogapi.embl.de/nog_data/html/tree/COG4166 eggNOG ENOG4105E43 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E43 epestfind swissprot:YEJA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEJA_ECOLI garnier swissprot:YEJA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEJA_ECOLI helixturnhelix swissprot:YEJA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEJA_ECOLI hmoment swissprot:YEJA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEJA_ECOLI iep swissprot:YEJA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEJA_ECOLI inforesidue swissprot:YEJA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEJA_ECOLI octanol swissprot:YEJA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEJA_ECOLI pepcoil swissprot:YEJA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEJA_ECOLI pepdigest swissprot:YEJA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEJA_ECOLI pepinfo swissprot:YEJA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEJA_ECOLI pepnet swissprot:YEJA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEJA_ECOLI pepstats swissprot:YEJA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEJA_ECOLI pepwheel swissprot:YEJA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEJA_ECOLI pepwindow swissprot:YEJA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEJA_ECOLI sigcleave swissprot:YEJA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEJA_ECOLI ## Database ID URL or Descriptions # AltName Hydroperoxidase I {ECO:0000303|PubMed 374409} # AltName Peroxidase/catalase {ECO:0000255|HAMAP-Rule MF_01961} # BIOPHYSICOCHEMICAL PROPERTIES KATG_ECOLI Kinetic parameters KM=35 mM for H(2)O(2) for the catalase reaction (at pH 5.5-6.0) {ECO 0000269|PubMed 18178143, ECO 0000269|PubMed 374409}; KM=4.2 mM for H(2)O(2) for the catalase reaction (at pH 7.0) {ECO 0000269|PubMed 18178143, ECO 0000269|PubMed 374409}; KM=3.9 mM for H(2)O(2) for the catalase reaction (at pH 7.5) {ECO 0000269|PubMed 18178143, ECO 0000269|PubMed 374409}; KM=60 uM for H(2)O(2) for the peroxidase reaction {ECO 0000269|PubMed 18178143, ECO 0000269|PubMed 374409}; KM=24 uM for ABTS for the peroxidase reaction {ECO 0000269|PubMed 18178143, ECO 0000269|PubMed 374409}; Vmax=3730 umol/min/mg enzyme for H(2)O(2) for the catalase reaction (at pH 5.5-6.0) {ECO 0000269|PubMed 18178143, ECO 0000269|PubMed 374409}; Vmax=2220 umol/min/mg enzyme for H(2)O(2) for the catalase reaction (at pH 7.0) {ECO 0000269|PubMed 18178143, ECO 0000269|PubMed 374409}; Vmax=18 umol/min/mg enzyme for ABTS for the peroxidase reaction {ECO 0000269|PubMed 18178143, ECO 0000269|PubMed 374409}; pH dependence Optimum pH is 4.25 for the peroxidase reaction and 7.5 for the catalase reaction. {ECO 0000269|PubMed 18178143, ECO 0000269|PubMed 374409}; # BioGrid 4263062 10 # CATALYTIC ACTIVITY 2 H(2)O(2) = O(2) + 2 H(2)O. {ECO:0000255|HAMAP-Rule MF_01961}. # CATALYTIC ACTIVITY Donor + H(2)O(2) = oxidized donor + 2 H(2)O. {ECO:0000255|HAMAP-Rule MF_01961}. # COFACTOR KATG_ECOLI Name=heme b; Xref=ChEBI CHEBI 60344; Evidence={ECO 0000269|PubMed 374409}; Note=Binds 2 heme B (iron-protoporphyrin IX) groups per tetramer. {ECO 0000269|PubMed 374409}; # DISRUPTION PHENOTYPE Cells are more sensitive to killing by nalidixic acid, the effect is mitigated by pretreatment with 2,2'- bipyridyl and thiourea, both of which inhibit hydroxyl radical accumulation. {ECO:0000269|PubMed 23416055}. # EcoGene EG10511 katG # FUNCTION KATG_ECOLI Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity. Displays also NADH oxidase, INH lyase and isonicotinoyl-NAD synthase activity. {ECO 0000269|PubMed 18178143, ECO 0000269|PubMed 23416055, ECO 0000269|PubMed 374409}. # GO_component GO:0005576 extracellular region; IBA:GO_Central. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0004096 catalase activity; IDA:EcoCyc. # GO_function GO:0004601 peroxidase activity; IDA:EcoCyc. # GO_function GO:0016491 oxidoreductase activity; IDA:EcoliWiki. # GO_function GO:0020037 heme binding; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006979 response to oxidative stress; IEP:EcoCyc. # GO_process GO:0042744 hydrogen peroxide catabolic process; IMP:EcoCyc. # GO_process GO:0070301 cellular response to hydrogen peroxide; IEP:EcoCyc. # GOslim_component GO:0005576 extracellular region # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009056 catabolic process # HAMAP MF_01961 Catal_peroxid # INDUCTION KATG_ECOLI By hydrogen peroxide. # IntAct P13029 11 # InterPro IPR000763 Catalase_peroxidase # InterPro IPR002016 Haem_peroxidase_pln/fun/bac # InterPro IPR010255 Haem_peroxidase # InterPro IPR019793 Peroxidases_heam-ligand_BS # InterPro IPR019794 Peroxidases_AS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00360 Phenylalanine metabolism # KEGG_Pathway ko00380 Tryptophan metabolism # KEGG_Pathway ko00680 Methane metabolism # KEGG_Pathway ko00940 Phenylpropanoid biosynthesis # Organism KATG_ECOLI Escherichia coli (strain K12) # PATRIC 32123405 VBIEscCol129921_4063 # PDB 1U2J X-ray; 2.30 A; A/B/C/D/E/F/G/H=422-726 # PDB 1U2K X-ray; 2.00 A; A=422-726 # PDB 1U2L X-ray; 2.30 A; A/B=422-726 # PIR A65201 CSECHP # PRINTS PR00458 PEROXIDASE # PRINTS PR00460 BPEROXIDASE # PROSITE PS00435 PEROXIDASE_1 # PROSITE PS00436 PEROXIDASE_2 # PROSITE PS50873 PEROXIDASE_4 # PTM KATG_ECOLI The N-terminus is blocked. # PTM KATG_ECOLI The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme. {ECO 0000255|HAMAP-Rule MF_01961}. # PeroxiBase 2394 EcoCP01_K-12 # Pfam PF00141 peroxidase; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Catalase-peroxidase {ECO:0000255|HAMAP-Rule MF_01961} # RefSeq NP_418377 NC_000913.3 # RefSeq WP_001295695 NZ_LN832404.1 # SIMILARITY Belongs to the peroxidase family. Peroxidase/catalase subfamily. {ECO:0000255|HAMAP-Rule MF_01961}. # SUBUNIT Homotetramer. {ECO:0000269|PubMed 374409}. # SUPFAM SSF48113 SSF48113; 2 # TIGRFAMs TIGR00198 cat_per_HPI # eggNOG COG0376 LUCA # eggNOG ENOG4105C1X Bacteria BLAST swissprot:KATG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:KATG_ECOLI BioCyc ECOL316407:JW3914-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3914-MONOMER BioCyc EcoCyc:HYDROPEROXIDI-MONOMER http://biocyc.org/getid?id=EcoCyc:HYDROPEROXIDI-MONOMER BioCyc MetaCyc:HYDROPEROXIDI-MONOMER http://biocyc.org/getid?id=MetaCyc:HYDROPEROXIDI-MONOMER COG COG0376 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0376 DIP DIP-10053N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10053N DOI 10.1016/j.abb.2007.12.008 http://dx.doi.org/10.1016/j.abb.2007.12.008 DOI 10.1016/j.celrep.2013.01.026 http://dx.doi.org/10.1016/j.celrep.2013.01.026 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M304053200 http://dx.doi.org/10.1074/jbc.M304053200 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1107/S0907444904020621 http://dx.doi.org/10.1107/S0907444904020621 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.11.1.21 {ECO:0000255|HAMAP-Rule:MF_01961} http://www.genome.jp/dbget-bin/www_bget?EC:1.11.1.21 {ECO:0000255|HAMAP-Rule:MF_01961} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL M21516 http://www.ebi.ac.uk/ena/data/view/M21516 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.11.1.21 {ECO:0000255|HAMAP-Rule:MF_01961} http://enzyme.expasy.org/EC/1.11.1.21 {ECO:0000255|HAMAP-Rule:MF_01961} EchoBASE EB0506 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0506 EcoGene EG10511 http://www.ecogene.org/geneInfo.php?eg_id=EG10511 EnsemblBacteria AAC76924 http://www.ensemblgenomes.org/id/AAC76924 EnsemblBacteria AAC76924 http://www.ensemblgenomes.org/id/AAC76924 EnsemblBacteria BAE77368 http://www.ensemblgenomes.org/id/BAE77368 EnsemblBacteria BAE77368 http://www.ensemblgenomes.org/id/BAE77368 EnsemblBacteria BAE77368 http://www.ensemblgenomes.org/id/BAE77368 EnsemblBacteria b3942 http://www.ensemblgenomes.org/id/b3942 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005576 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004096 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004096 GO_function GO:0004601 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004601 GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0020037 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0020037 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979 GO_process GO:0042744 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042744 GO_process GO:0070301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070301 GOslim_component GO:0005576 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005576 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GeneID 948431 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948431 HAMAP MF_01961 http://hamap.expasy.org/unirule/MF_01961 HOGENOM HOG000218110 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000218110&db=HOGENOM6 InParanoid P13029 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P13029 IntAct P13029 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P13029* IntEnz 1.11.1.21 {ECO:0000255|HAMAP-Rule:MF_01961} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.11.1.21 {ECO:0000255|HAMAP-Rule:MF_01961} InterPro IPR000763 http://www.ebi.ac.uk/interpro/entry/IPR000763 InterPro IPR002016 http://www.ebi.ac.uk/interpro/entry/IPR002016 InterPro IPR010255 http://www.ebi.ac.uk/interpro/entry/IPR010255 InterPro IPR019793 http://www.ebi.ac.uk/interpro/entry/IPR019793 InterPro IPR019794 http://www.ebi.ac.uk/interpro/entry/IPR019794 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3914 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3914 KEGG_Gene eco:b3942 http://www.genome.jp/dbget-bin/www_bget?eco:b3942 KEGG_Orthology KO:K03782 http://www.genome.jp/dbget-bin/www_bget?KO:K03782 KEGG_Pathway ko00360 http://www.genome.jp/kegg-bin/show_pathway?ko00360 KEGG_Pathway ko00380 http://www.genome.jp/kegg-bin/show_pathway?ko00380 KEGG_Pathway ko00680 http://www.genome.jp/kegg-bin/show_pathway?ko00680 KEGG_Pathway ko00940 http://www.genome.jp/kegg-bin/show_pathway?ko00940 KEGG_Reaction rn:R00602 http://www.genome.jp/dbget-bin/www_bget?rn:R00602 KEGG_Reaction rn:R00698 http://www.genome.jp/dbget-bin/www_bget?rn:R00698 KEGG_Reaction rn:R02596 http://www.genome.jp/dbget-bin/www_bget?rn:R02596 KEGG_Reaction rn:R02670 http://www.genome.jp/dbget-bin/www_bget?rn:R02670 KEGG_Reaction rn:R03919 http://www.genome.jp/dbget-bin/www_bget?rn:R03919 KEGG_Reaction rn:R04007 http://www.genome.jp/dbget-bin/www_bget?rn:R04007 KEGG_Reaction rn:R07443 http://www.genome.jp/dbget-bin/www_bget?rn:R07443 MINT MINT-1304887 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1304887 OMA IAEVYAC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IAEVYAC PDB 1U2J http://www.ebi.ac.uk/pdbe-srv/view/entry/1U2J PDB 1U2K http://www.ebi.ac.uk/pdbe-srv/view/entry/1U2K PDB 1U2L http://www.ebi.ac.uk/pdbe-srv/view/entry/1U2L PDBsum 1U2J http://www.ebi.ac.uk/pdbsum/1U2J PDBsum 1U2K http://www.ebi.ac.uk/pdbsum/1U2K PDBsum 1U2L http://www.ebi.ac.uk/pdbsum/1U2L PRINTS PR00458 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00458 PRINTS PR00460 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00460 PROSITE PS00435 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00435 PROSITE PS00436 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00436 PROSITE PS50873 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50873 PSORT swissprot:KATG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:KATG_ECOLI PSORT-B swissprot:KATG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:KATG_ECOLI PSORT2 swissprot:KATG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:KATG_ECOLI PeroxiBase 2394 http://peroxibase.toulouse.inra.fr/listing.php?action=view&id=2394 Pfam PF00141 http://pfam.xfam.org/family/PF00141 Phobius swissprot:KATG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:KATG_ECOLI PhylomeDB P13029 http://phylomedb.org/?seqid=P13029 ProteinModelPortal P13029 http://www.proteinmodelportal.org/query/uniprot/P13029 PubMed 12832453 http://www.ncbi.nlm.nih.gov/pubmed/12832453 PubMed 15388929 http://www.ncbi.nlm.nih.gov/pubmed/15388929 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18178143 http://www.ncbi.nlm.nih.gov/pubmed/18178143 PubMed 23416055 http://www.ncbi.nlm.nih.gov/pubmed/23416055 PubMed 3045098 http://www.ncbi.nlm.nih.gov/pubmed/3045098 PubMed 374409 http://www.ncbi.nlm.nih.gov/pubmed/374409 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418377 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418377 RefSeq WP_001295695 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295695 SMR P13029 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P13029 STRING 511145.b3942 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3942&targetmode=cogs STRING COG0376 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0376&targetmode=cogs SUPFAM SSF48113 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48113 SWISS-2DPAGE P13029 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P13029 TIGRFAMs TIGR00198 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00198 UniProtKB KATG_ECOLI http://www.uniprot.org/uniprot/KATG_ECOLI UniProtKB-AC P13029 http://www.uniprot.org/uniprot/P13029 charge swissprot:KATG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:KATG_ECOLI eggNOG COG0376 http://eggnogapi.embl.de/nog_data/html/tree/COG0376 eggNOG ENOG4105C1X http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C1X epestfind swissprot:KATG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:KATG_ECOLI garnier swissprot:KATG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:KATG_ECOLI helixturnhelix swissprot:KATG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:KATG_ECOLI hmoment swissprot:KATG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:KATG_ECOLI iep swissprot:KATG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:KATG_ECOLI inforesidue swissprot:KATG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:KATG_ECOLI octanol swissprot:KATG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:KATG_ECOLI pepcoil swissprot:KATG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:KATG_ECOLI pepdigest swissprot:KATG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:KATG_ECOLI pepinfo swissprot:KATG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:KATG_ECOLI pepnet swissprot:KATG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:KATG_ECOLI pepstats swissprot:KATG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:KATG_ECOLI pepwheel swissprot:KATG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:KATG_ECOLI pepwindow swissprot:KATG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:KATG_ECOLI sigcleave swissprot:KATG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:KATG_ECOLI ## Database ID URL or Descriptions # BioGrid 4260595 11 # EcoGene EG13215 yfhL # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # IntAct P52102 12 # InterPro IPR017896 4Fe4S_Fe-S-bd # InterPro IPR017900 4Fe4S_Fe_S_CS # Organism YFHL_ECOLI Escherichia coli (strain K12) # PATRIC 32120523 VBIEscCol129921_2664 # PDB 2ZVS X-ray; 1.65 A; A/B/C=2-86 # PIR A65034 A65034 # PROSITE PS00198 4FE4S_FER_1 # PROSITE PS51379 4FE4S_FER_2; 2 # Pfam PF00037 Fer4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFHL_ECOLI Uncharacterized ferredoxin-like protein YfhL # RefSeq NP_417057 NC_000913.3 # RefSeq WP_001196283 NZ_LN832404.1 # SIMILARITY Contains 2 4Fe-4S ferredoxin-type domains. {ECO:0000255|PROSITE-ProRule PRU00711}. # eggNOG COG1145 LUCA # eggNOG ENOG4105K5D Bacteria BLAST swissprot:YFHL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFHL_ECOLI BioCyc ECOL316407:JW2546-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2546-MONOMER BioCyc EcoCyc:G7346-MONOMER http://biocyc.org/getid?id=EcoCyc:G7346-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36841 http://www.ebi.ac.uk/ena/data/view/U36841 EchoBASE EB3006 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3006 EcoGene EG13215 http://www.ecogene.org/geneInfo.php?eg_id=EG13215 EnsemblBacteria AAC75615 http://www.ensemblgenomes.org/id/AAC75615 EnsemblBacteria AAC75615 http://www.ensemblgenomes.org/id/AAC75615 EnsemblBacteria BAE76738 http://www.ensemblgenomes.org/id/BAE76738 EnsemblBacteria BAE76738 http://www.ensemblgenomes.org/id/BAE76738 EnsemblBacteria BAE76738 http://www.ensemblgenomes.org/id/BAE76738 EnsemblBacteria b2562 http://www.ensemblgenomes.org/id/b2562 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GeneID 947031 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947031 HOGENOM HOG000044615 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000044615&db=HOGENOM6 InParanoid P52102 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P52102 IntAct P52102 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P52102* InterPro IPR017896 http://www.ebi.ac.uk/interpro/entry/IPR017896 InterPro IPR017900 http://www.ebi.ac.uk/interpro/entry/IPR017900 KEGG_Gene ecj:JW2546 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2546 KEGG_Gene eco:b2562 http://www.genome.jp/dbget-bin/www_bget?eco:b2562 OMA CPVECII http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CPVECII PDB 2ZVS http://www.ebi.ac.uk/pdbe-srv/view/entry/2ZVS PDBsum 2ZVS http://www.ebi.ac.uk/pdbsum/2ZVS PROSITE PS00198 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00198 PROSITE PS51379 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51379 PSORT swissprot:YFHL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFHL_ECOLI PSORT-B swissprot:YFHL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFHL_ECOLI PSORT2 swissprot:YFHL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFHL_ECOLI Pfam PF00037 http://pfam.xfam.org/family/PF00037 Phobius swissprot:YFHL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFHL_ECOLI PhylomeDB P52102 http://phylomedb.org/?seqid=P52102 ProteinModelPortal P52102 http://www.proteinmodelportal.org/query/uniprot/P52102 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417057 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417057 RefSeq WP_001196283 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001196283 SMR P52102 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P52102 STRING 511145.b2562 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2562&targetmode=cogs UniProtKB YFHL_ECOLI http://www.uniprot.org/uniprot/YFHL_ECOLI UniProtKB-AC P52102 http://www.uniprot.org/uniprot/P52102 charge swissprot:YFHL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFHL_ECOLI eggNOG COG1145 http://eggnogapi.embl.de/nog_data/html/tree/COG1145 eggNOG ENOG4105K5D http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K5D epestfind swissprot:YFHL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFHL_ECOLI garnier swissprot:YFHL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFHL_ECOLI helixturnhelix swissprot:YFHL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFHL_ECOLI hmoment swissprot:YFHL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFHL_ECOLI iep swissprot:YFHL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFHL_ECOLI inforesidue swissprot:YFHL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFHL_ECOLI octanol swissprot:YFHL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFHL_ECOLI pepcoil swissprot:YFHL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFHL_ECOLI pepdigest swissprot:YFHL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFHL_ECOLI pepinfo swissprot:YFHL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFHL_ECOLI pepnet swissprot:YFHL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFHL_ECOLI pepstats swissprot:YFHL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFHL_ECOLI pepwheel swissprot:YFHL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFHL_ECOLI pepwindow swissprot:YFHL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFHL_ECOLI sigcleave swissprot:YFHL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFHL_ECOLI ## Database ID URL or Descriptions # BioGrid 4263117 2 # COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI 29105; Note=Binds 1 zinc ion per subunit.; # EcoGene EG10811 pyrI # FUNCTION PYRI_ECOLI Involved in allosteric regulation of aspartate carbamoyltransferase. # GO_component GO:0005737 cytoplasm; IDA:UniProtKB. # GO_component GO:0009347 aspartate carbamoyltransferase complex; IEA:InterPro. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_process GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro. # GO_process GO:0006221 pyrimidine nucleotide biosynthetic process; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 2.30.30.20 -; 1. # Gene3D 3.30.70.140 -; 1. # HAMAP MF_00002 Asp_carb_tr_reg # INTERACTION PYRI_ECOLI P0A786 pyrB; NbExp=14; IntAct=EBI-906630, EBI-906620; # IntAct P0A7F3 2 # InterPro IPR002801 Asp_carbamoylTrfase_reg # InterPro IPR020542 Asp_carbamoyltrfase_reg_C # InterPro IPR020545 Asp_carbamoyltransf_reg_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Pathway ko00240 Pyrimidine metabolism # KEGG_Pathway ko00250 Alanine, aspartate and glutamate metabolism # Organism PYRI_ECOLI Escherichia coli (strain K12) # PATRIC 32124065 VBIEscCol129921_4377 # PDB 1ACM X-ray; 2.80 A; B/D=1-153 # PDB 1AT1 X-ray; 2.80 A; B/D=1-153 # PDB 1D09 X-ray; 2.10 A; B/D=1-153 # PDB 1EZZ X-ray; 2.70 A; B/D=1-153 # PDB 1F1B X-ray; 2.30 A; B/D=1-153 # PDB 1I5O X-ray; 2.80 A; B/D=1-153 # PDB 1NBE X-ray; 2.60 A; B/D=1-153 # PDB 1Q95 X-ray; 2.46 A; G/H/I/J/K/L=1-153 # PDB 1R0B X-ray; 2.90 A; G/H/I/J/K/L=1-153 # PDB 1R0C X-ray; 2.37 A; B/H=1-153 # PDB 1RAA X-ray; 2.50 A; B/D=1-153 # PDB 1RAB X-ray; 2.50 A; B/D=1-153 # PDB 1RAC X-ray; 2.50 A; B/D=1-153 # PDB 1RAD X-ray; 2.50 A; B/D=1-153 # PDB 1RAE X-ray; 2.50 A; B/D=1-153 # PDB 1RAF X-ray; 2.50 A; B/D=1-153 # PDB 1RAG X-ray; 2.50 A; B/D=1-153 # PDB 1RAH X-ray; 2.50 A; B/D=1-153 # PDB 1RAI X-ray; 2.50 A; B/D=1-153 # PDB 1SKU X-ray; 2.60 A; B/D=1-153 # PDB 1TTH X-ray; 2.80 A; B/D=1-153 # PDB 1TU0 X-ray; 2.55 A; B/D=1-153 # PDB 1TUG X-ray; 2.10 A; B/D=1-153 # PDB 1XJW X-ray; 2.71 A; B/D=1-153 # PDB 1ZA1 X-ray; 2.20 A; B/D=1-153 # PDB 1ZA2 X-ray; 2.50 A; B/D=1-153 # PDB 2A0F X-ray; 2.90 A; B/D=1-153 # PDB 2AIR X-ray; 2.00 A; B/H=1-153 # PDB 2AT1 X-ray; 2.80 A; B/D=1-153 # PDB 2ATC X-ray; 3.00 A; B=1-153 # PDB 2FZC X-ray; 2.10 A; B/D=1-153 # PDB 2FZG X-ray; 2.25 A; B/D=1-153 # PDB 2FZK X-ray; 2.50 A; B/D=1-153 # PDB 2H3E X-ray; 2.30 A; B/D=1-153 # PDB 2HSE X-ray; 2.60 A; B/D=1-153 # PDB 2IPO X-ray; 2.60 A; B/D=1-153 # PDB 2QG9 X-ray; 2.70 A; B/D=1-153 # PDB 2QGF X-ray; 2.20 A; B/D=1-153 # PDB 3AT1 X-ray; 2.80 A; B/D=1-153 # PDB 3D7S X-ray; 2.80 A; B/D=1-153 # PDB 3MPU X-ray; 2.86 A; B/D/F=1-153 # PDB 4AT1 X-ray; 2.60 A; B/D=1-153 # PDB 4E2F X-ray; 2.80 A; B/D/F/H/J/L=1-153 # PDB 4F04 X-ray; 2.30 A; B/D=1-153 # PDB 4FYV X-ray; 2.10 A; B/D=1-153 # PDB 4FYW X-ray; 2.10 A; B/D=1-153 # PDB 4FYX X-ray; 2.09 A; B/D=1-153 # PDB 4FYY X-ray; 1.94 A; B/D=1-153 # PDB 4WTO X-ray; 2.03 A; B/D=1-153 # PDB 5AT1 X-ray; 2.60 A; B/D=1-153 # PDB 6AT1 X-ray; 2.60 A; B/D=1-153 # PDB 7AT1 X-ray; 2.80 A; B/D=1-153 # PDB 8AT1 X-ray; 2.80 A; B/D=1-153 # PDB 8ATC X-ray; 2.50 A; B/D=1-153 # PDB 9ATC X-ray; 2.40 A; B=8-153 # PIR A93985 DTECR # Pfam PF01948 PyrI # Pfam PF02748 PyrI_C # ProDom PD006194 Asp_carbamoylTrfase_reg # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PYRI_ECOLI Aspartate carbamoyltransferase regulatory chain # RefSeq NP_418665 NC_000913.3 # RefSeq WP_000148581 NZ_LN832404.1 # SIMILARITY Belongs to the PyrI family. {ECO 0000305}. # SUBUNIT Heterododecamer (2C3:3R2) of six catalytic PyrB chains organized as two trimers (C3), and six regulatory PyrI chains organized as three dimers (R2). {ECO 0000269|PubMed:6377306}. # SUPFAM SSF54893 SSF54893 # SUPFAM SSF57825 SSF57825 # TIGRFAMs TIGR00240 ATCase_reg # eggNOG COG1781 LUCA # eggNOG ENOG4108R9M Bacteria BLAST swissprot:PYRI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PYRI_ECOLI BioCyc ECOL316407:JW4203-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4203-MONOMER BioCyc EcoCyc:ASPCARBREG-MONOMER http://biocyc.org/getid?id=EcoCyc:ASPCARBREG-MONOMER BioCyc MetaCyc:ASPCARBREG-MONOMER http://biocyc.org/getid?id=MetaCyc:ASPCARBREG-MONOMER COG COG1781 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1781 DIP DIP-35088N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35088N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1016/0022-2836(85)90390-0 http://dx.doi.org/10.1016/0022-2836(85)90390-0 DOI 10.1021/bi00485a019 http://dx.doi.org/10.1021/bi00485a019 DOI 10.1021/bi00485a020 http://dx.doi.org/10.1021/bi00485a020 DOI 10.1038/2181116a0 http://dx.doi.org/10.1038/2181116a0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.75.11.5276 http://dx.doi.org/10.1073/pnas.75.11.5276 DOI 10.1073/pnas.81.1.115 http://dx.doi.org/10.1073/pnas.81.1.115 DOI 10.1073/pnas.81.13.4037 http://dx.doi.org/10.1073/pnas.81.13.4037 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K01472 http://www.ebi.ac.uk/ena/data/view/K01472 EMBL M28578 http://www.ebi.ac.uk/ena/data/view/M28578 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB0804 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0804 EcoGene EG10811 http://www.ecogene.org/geneInfo.php?eg_id=EG10811 EnsemblBacteria AAC77201 http://www.ensemblgenomes.org/id/AAC77201 EnsemblBacteria AAC77201 http://www.ensemblgenomes.org/id/AAC77201 EnsemblBacteria BAE78243 http://www.ensemblgenomes.org/id/BAE78243 EnsemblBacteria BAE78243 http://www.ensemblgenomes.org/id/BAE78243 EnsemblBacteria BAE78243 http://www.ensemblgenomes.org/id/BAE78243 EnsemblBacteria b4244 http://www.ensemblgenomes.org/id/b4244 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0009347 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009347 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_process GO:0006207 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006207 GO_process GO:0006221 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006221 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 2.30.30.20 http://www.cathdb.info/version/latest/superfamily/2.30.30.20 Gene3D 3.30.70.140 http://www.cathdb.info/version/latest/superfamily/3.30.70.140 GeneID 948763 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948763 HAMAP MF_00002 http://hamap.expasy.org/unirule/MF_00002 HOGENOM HOG000113530 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000113530&db=HOGENOM6 InParanoid P0A7F3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A7F3 IntAct P0A7F3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A7F3* InterPro IPR002801 http://www.ebi.ac.uk/interpro/entry/IPR002801 InterPro IPR020542 http://www.ebi.ac.uk/interpro/entry/IPR020542 InterPro IPR020545 http://www.ebi.ac.uk/interpro/entry/IPR020545 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Gene ecj:JW4203 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4203 KEGG_Gene eco:b4244 http://www.genome.jp/dbget-bin/www_bget?eco:b4244 KEGG_Orthology KO:K00610 http://www.genome.jp/dbget-bin/www_bget?KO:K00610 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Pathway ko00250 http://www.genome.jp/kegg-bin/show_pathway?ko00250 KEGG_Reaction rn:R01397 http://www.genome.jp/dbget-bin/www_bget?rn:R01397 MINT MINT-1541364 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1541364 OMA MNVPSDR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MNVPSDR PDB 1ACM http://www.ebi.ac.uk/pdbe-srv/view/entry/1ACM PDB 1AT1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1AT1 PDB 1D09 http://www.ebi.ac.uk/pdbe-srv/view/entry/1D09 PDB 1EZZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1EZZ PDB 1F1B http://www.ebi.ac.uk/pdbe-srv/view/entry/1F1B PDB 1I5O http://www.ebi.ac.uk/pdbe-srv/view/entry/1I5O PDB 1NBE http://www.ebi.ac.uk/pdbe-srv/view/entry/1NBE PDB 1Q95 http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q95 PDB 1R0B http://www.ebi.ac.uk/pdbe-srv/view/entry/1R0B PDB 1R0C http://www.ebi.ac.uk/pdbe-srv/view/entry/1R0C PDB 1RAA http://www.ebi.ac.uk/pdbe-srv/view/entry/1RAA PDB 1RAB http://www.ebi.ac.uk/pdbe-srv/view/entry/1RAB PDB 1RAC http://www.ebi.ac.uk/pdbe-srv/view/entry/1RAC PDB 1RAD http://www.ebi.ac.uk/pdbe-srv/view/entry/1RAD PDB 1RAE http://www.ebi.ac.uk/pdbe-srv/view/entry/1RAE PDB 1RAF http://www.ebi.ac.uk/pdbe-srv/view/entry/1RAF PDB 1RAG http://www.ebi.ac.uk/pdbe-srv/view/entry/1RAG PDB 1RAH http://www.ebi.ac.uk/pdbe-srv/view/entry/1RAH PDB 1RAI http://www.ebi.ac.uk/pdbe-srv/view/entry/1RAI PDB 1SKU http://www.ebi.ac.uk/pdbe-srv/view/entry/1SKU PDB 1TTH http://www.ebi.ac.uk/pdbe-srv/view/entry/1TTH PDB 1TU0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1TU0 PDB 1TUG http://www.ebi.ac.uk/pdbe-srv/view/entry/1TUG PDB 1XJW http://www.ebi.ac.uk/pdbe-srv/view/entry/1XJW PDB 1ZA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZA1 PDB 1ZA2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZA2 PDB 2A0F http://www.ebi.ac.uk/pdbe-srv/view/entry/2A0F PDB 2AIR http://www.ebi.ac.uk/pdbe-srv/view/entry/2AIR PDB 2AT1 http://www.ebi.ac.uk/pdbe-srv/view/entry/2AT1 PDB 2ATC http://www.ebi.ac.uk/pdbe-srv/view/entry/2ATC PDB 2FZC http://www.ebi.ac.uk/pdbe-srv/view/entry/2FZC PDB 2FZG http://www.ebi.ac.uk/pdbe-srv/view/entry/2FZG PDB 2FZK http://www.ebi.ac.uk/pdbe-srv/view/entry/2FZK PDB 2H3E http://www.ebi.ac.uk/pdbe-srv/view/entry/2H3E PDB 2HSE http://www.ebi.ac.uk/pdbe-srv/view/entry/2HSE PDB 2IPO http://www.ebi.ac.uk/pdbe-srv/view/entry/2IPO PDB 2QG9 http://www.ebi.ac.uk/pdbe-srv/view/entry/2QG9 PDB 2QGF http://www.ebi.ac.uk/pdbe-srv/view/entry/2QGF PDB 3AT1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3AT1 PDB 3D7S http://www.ebi.ac.uk/pdbe-srv/view/entry/3D7S PDB 3MPU http://www.ebi.ac.uk/pdbe-srv/view/entry/3MPU PDB 4AT1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4AT1 PDB 4E2F http://www.ebi.ac.uk/pdbe-srv/view/entry/4E2F PDB 4F04 http://www.ebi.ac.uk/pdbe-srv/view/entry/4F04 PDB 4FYV http://www.ebi.ac.uk/pdbe-srv/view/entry/4FYV PDB 4FYW http://www.ebi.ac.uk/pdbe-srv/view/entry/4FYW PDB 4FYX http://www.ebi.ac.uk/pdbe-srv/view/entry/4FYX PDB 4FYY http://www.ebi.ac.uk/pdbe-srv/view/entry/4FYY PDB 4WTO http://www.ebi.ac.uk/pdbe-srv/view/entry/4WTO PDB 5AT1 http://www.ebi.ac.uk/pdbe-srv/view/entry/5AT1 PDB 6AT1 http://www.ebi.ac.uk/pdbe-srv/view/entry/6AT1 PDB 7AT1 http://www.ebi.ac.uk/pdbe-srv/view/entry/7AT1 PDB 8AT1 http://www.ebi.ac.uk/pdbe-srv/view/entry/8AT1 PDB 8ATC http://www.ebi.ac.uk/pdbe-srv/view/entry/8ATC PDB 9ATC http://www.ebi.ac.uk/pdbe-srv/view/entry/9ATC PDBsum 1ACM http://www.ebi.ac.uk/pdbsum/1ACM PDBsum 1AT1 http://www.ebi.ac.uk/pdbsum/1AT1 PDBsum 1D09 http://www.ebi.ac.uk/pdbsum/1D09 PDBsum 1EZZ http://www.ebi.ac.uk/pdbsum/1EZZ PDBsum 1F1B http://www.ebi.ac.uk/pdbsum/1F1B PDBsum 1I5O http://www.ebi.ac.uk/pdbsum/1I5O PDBsum 1NBE http://www.ebi.ac.uk/pdbsum/1NBE PDBsum 1Q95 http://www.ebi.ac.uk/pdbsum/1Q95 PDBsum 1R0B http://www.ebi.ac.uk/pdbsum/1R0B PDBsum 1R0C http://www.ebi.ac.uk/pdbsum/1R0C PDBsum 1RAA http://www.ebi.ac.uk/pdbsum/1RAA PDBsum 1RAB http://www.ebi.ac.uk/pdbsum/1RAB PDBsum 1RAC http://www.ebi.ac.uk/pdbsum/1RAC PDBsum 1RAD http://www.ebi.ac.uk/pdbsum/1RAD PDBsum 1RAE http://www.ebi.ac.uk/pdbsum/1RAE PDBsum 1RAF http://www.ebi.ac.uk/pdbsum/1RAF PDBsum 1RAG http://www.ebi.ac.uk/pdbsum/1RAG PDBsum 1RAH http://www.ebi.ac.uk/pdbsum/1RAH PDBsum 1RAI http://www.ebi.ac.uk/pdbsum/1RAI PDBsum 1SKU http://www.ebi.ac.uk/pdbsum/1SKU PDBsum 1TTH http://www.ebi.ac.uk/pdbsum/1TTH PDBsum 1TU0 http://www.ebi.ac.uk/pdbsum/1TU0 PDBsum 1TUG http://www.ebi.ac.uk/pdbsum/1TUG PDBsum 1XJW http://www.ebi.ac.uk/pdbsum/1XJW PDBsum 1ZA1 http://www.ebi.ac.uk/pdbsum/1ZA1 PDBsum 1ZA2 http://www.ebi.ac.uk/pdbsum/1ZA2 PDBsum 2A0F http://www.ebi.ac.uk/pdbsum/2A0F PDBsum 2AIR http://www.ebi.ac.uk/pdbsum/2AIR PDBsum 2AT1 http://www.ebi.ac.uk/pdbsum/2AT1 PDBsum 2ATC http://www.ebi.ac.uk/pdbsum/2ATC PDBsum 2FZC http://www.ebi.ac.uk/pdbsum/2FZC PDBsum 2FZG http://www.ebi.ac.uk/pdbsum/2FZG PDBsum 2FZK http://www.ebi.ac.uk/pdbsum/2FZK PDBsum 2H3E http://www.ebi.ac.uk/pdbsum/2H3E PDBsum 2HSE http://www.ebi.ac.uk/pdbsum/2HSE PDBsum 2IPO http://www.ebi.ac.uk/pdbsum/2IPO PDBsum 2QG9 http://www.ebi.ac.uk/pdbsum/2QG9 PDBsum 2QGF http://www.ebi.ac.uk/pdbsum/2QGF PDBsum 3AT1 http://www.ebi.ac.uk/pdbsum/3AT1 PDBsum 3D7S http://www.ebi.ac.uk/pdbsum/3D7S PDBsum 3MPU http://www.ebi.ac.uk/pdbsum/3MPU PDBsum 4AT1 http://www.ebi.ac.uk/pdbsum/4AT1 PDBsum 4E2F http://www.ebi.ac.uk/pdbsum/4E2F PDBsum 4F04 http://www.ebi.ac.uk/pdbsum/4F04 PDBsum 4FYV http://www.ebi.ac.uk/pdbsum/4FYV PDBsum 4FYW http://www.ebi.ac.uk/pdbsum/4FYW PDBsum 4FYX http://www.ebi.ac.uk/pdbsum/4FYX PDBsum 4FYY http://www.ebi.ac.uk/pdbsum/4FYY PDBsum 4WTO http://www.ebi.ac.uk/pdbsum/4WTO PDBsum 5AT1 http://www.ebi.ac.uk/pdbsum/5AT1 PDBsum 6AT1 http://www.ebi.ac.uk/pdbsum/6AT1 PDBsum 7AT1 http://www.ebi.ac.uk/pdbsum/7AT1 PDBsum 8AT1 http://www.ebi.ac.uk/pdbsum/8AT1 PDBsum 8ATC http://www.ebi.ac.uk/pdbsum/8ATC PDBsum 9ATC http://www.ebi.ac.uk/pdbsum/9ATC PSORT swissprot:PYRI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PYRI_ECOLI PSORT-B swissprot:PYRI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PYRI_ECOLI PSORT2 swissprot:PYRI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PYRI_ECOLI Pfam PF01948 http://pfam.xfam.org/family/PF01948 Pfam PF02748 http://pfam.xfam.org/family/PF02748 Phobius swissprot:PYRI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PYRI_ECOLI PhylomeDB P0A7F3 http://phylomedb.org/?seqid=P0A7F3 ProteinModelPortal P0A7F3 http://www.proteinmodelportal.org/query/uniprot/P0A7F3 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2271528 http://www.ncbi.nlm.nih.gov/pubmed/2271528 PubMed 2271529 http://www.ncbi.nlm.nih.gov/pubmed/2271529 PubMed 364472 http://www.ncbi.nlm.nih.gov/pubmed/364472 PubMed 3912513 http://www.ncbi.nlm.nih.gov/pubmed/3912513 PubMed 4872216 http://www.ncbi.nlm.nih.gov/pubmed/4872216 PubMed 6364131 http://www.ncbi.nlm.nih.gov/pubmed/6364131 PubMed 6377306 http://www.ncbi.nlm.nih.gov/pubmed/6377306 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_418665 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418665 RefSeq WP_000148581 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000148581 SMR P0A7F3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A7F3 STRING 511145.b4244 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4244&targetmode=cogs STRING COG1781 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1781&targetmode=cogs SUPFAM SSF54893 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54893 SUPFAM SSF57825 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF57825 SWISS-2DPAGE P0A7F3 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A7F3 TIGRFAMs TIGR00240 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00240 UniProtKB PYRI_ECOLI http://www.uniprot.org/uniprot/PYRI_ECOLI UniProtKB-AC P0A7F3 http://www.uniprot.org/uniprot/P0A7F3 charge swissprot:PYRI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PYRI_ECOLI eggNOG COG1781 http://eggnogapi.embl.de/nog_data/html/tree/COG1781 eggNOG ENOG4108R9M http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108R9M epestfind swissprot:PYRI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PYRI_ECOLI garnier swissprot:PYRI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PYRI_ECOLI helixturnhelix swissprot:PYRI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PYRI_ECOLI hmoment swissprot:PYRI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PYRI_ECOLI iep swissprot:PYRI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PYRI_ECOLI inforesidue swissprot:PYRI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PYRI_ECOLI octanol swissprot:PYRI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PYRI_ECOLI pepcoil swissprot:PYRI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PYRI_ECOLI pepdigest swissprot:PYRI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PYRI_ECOLI pepinfo swissprot:PYRI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PYRI_ECOLI pepnet swissprot:PYRI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PYRI_ECOLI pepstats swissprot:PYRI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PYRI_ECOLI pepwheel swissprot:PYRI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PYRI_ECOLI pepwindow swissprot:PYRI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PYRI_ECOLI sigcleave swissprot:PYRI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PYRI_ECOLI ## Database ID URL or Descriptions # AltName Rare lipoprotein A {ECO:0000303|PubMed 3316191} # BioGrid 4260680 169 # DISRUPTION PHENOTYPE Deletion does not result in any obvious growth or division defects. {ECO:0000269|PubMed 19684127}. # DOMAIN RLPA_ECOLI The SPOR domain binds septal peptidoglycans and is required to target RlpA to the septal ring. {ECO 0000269|PubMed 19880599}. # EcoGene EG10854 rlpA # FUNCTION RLPA_ECOLI Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. {ECO 0000255|HAMAP- Rule MF_02071}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0009279 cell outer membrane; IDA:EcoCyc. # GO_function GO:0016829 lyase activity; IEA:UniProtKB-KW. # GO_function GO:0042834 peptidoglycan binding; IEA:InterPro. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 3.30.70.1070 -; 1. # HAMAP MF_02071 RlpA # InterPro IPR007730 SPOR_dom # InterPro IPR009009 RlpA-like_DPBB # InterPro IPR012997 RplA # Organism RLPA_ECOLI Escherichia coli (strain K12) # PATRIC 32116449 VBIEscCol129921_0664 # PIR A28387 LPECRA # PROSITE PS51257 PROKAR_LIPOPROTEIN # PROSITE PS51724 SPOR # Pfam PF03330 DPBB_1 # Pfam PF05036 SPOR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Endolytic peptidoglycan transglycosylase RlpA {ECO:0000255|HAMAP-Rule MF_02071} # RefSeq NP_415166 NC_000913.3 # RefSeq WP_001231430 NZ_LN832404.1 # SIMILARITY Belongs to the RlpA family. {ECO:0000255|HAMAP- Rule MF_02071}. # SIMILARITY Contains 1 SPOR domain. {ECO:0000255|HAMAP- Rule MF_02071}. # SUBCELLULAR LOCATION RLPA_ECOLI Cell membrane {ECO 0000255|HAMAP- Rule MF_02071}; Lipid-anchor {ECO 0000255|HAMAP-Rule MF_02071, ECO 0000305|PubMed 3316191}. Note=Localizes at the septal ring. Is also associated with some other structures/complexes along the cell cylinder. {ECO 0000269|PubMed 19684127, ECO 0000269|PubMed 19880599}. # SUPFAM SSF110997 SSF110997 # SUPFAM SSF50685 SSF50685 # TIGRFAMs TIGR00413 rlpA # eggNOG COG0797 LUCA # eggNOG ENOG4105K6T Bacteria BLAST swissprot:RLPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RLPA_ECOLI BioCyc ECOL316407:JW0628-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0628-MONOMER BioCyc EcoCyc:EG10854-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10854-MONOMER COG COG0797 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0797 DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00811-09 http://dx.doi.org/10.1128/JB.00811-09 DOI 10.1128/JB.01244-09 http://dx.doi.org/10.1128/JB.01244-09 EC_number EC:4.2.2.- {ECO:0000255|HAMAP-Rule:MF_02071} http://www.genome.jp/dbget-bin/www_bget?EC:4.2.2.- {ECO:0000255|HAMAP-Rule:MF_02071} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M18276 http://www.ebi.ac.uk/ena/data/view/M18276 EMBL M22857 http://www.ebi.ac.uk/ena/data/view/M22857 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 ENZYME 4.2.2.- {ECO:0000255|HAMAP-Rule:MF_02071} http://enzyme.expasy.org/EC/4.2.2.- {ECO:0000255|HAMAP-Rule:MF_02071} EchoBASE EB0847 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0847 EcoGene EG10854 http://www.ecogene.org/geneInfo.php?eg_id=EG10854 EnsemblBacteria AAC73734 http://www.ensemblgenomes.org/id/AAC73734 EnsemblBacteria AAC73734 http://www.ensemblgenomes.org/id/AAC73734 EnsemblBacteria BAA35276 http://www.ensemblgenomes.org/id/BAA35276 EnsemblBacteria BAA35276 http://www.ensemblgenomes.org/id/BAA35276 EnsemblBacteria BAA35276 http://www.ensemblgenomes.org/id/BAA35276 EnsemblBacteria b0633 http://www.ensemblgenomes.org/id/b0633 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0009279 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009279 GO_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GO_function GO:0042834 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042834 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 3.30.70.1070 http://www.cathdb.info/version/latest/superfamily/3.30.70.1070 GeneID 945241 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945241 HAMAP MF_02071 http://hamap.expasy.org/unirule/MF_02071 HOGENOM HOG000117956 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117956&db=HOGENOM6 InParanoid P10100 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P10100 IntAct P10100 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P10100* IntEnz 4.2.2.- {ECO:0000255|HAMAP-Rule:MF_02071} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.2.- {ECO:0000255|HAMAP-Rule:MF_02071} InterPro IPR007730 http://www.ebi.ac.uk/interpro/entry/IPR007730 InterPro IPR009009 http://www.ebi.ac.uk/interpro/entry/IPR009009 InterPro IPR012997 http://www.ebi.ac.uk/interpro/entry/IPR012997 KEGG_Gene ecj:JW0628 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0628 KEGG_Gene eco:b0633 http://www.genome.jp/dbget-bin/www_bget?eco:b0633 KEGG_Orthology KO:K03642 http://www.genome.jp/dbget-bin/www_bget?KO:K03642 OMA QSFIAVA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QSFIAVA PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PROSITE PS51724 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51724 PSORT swissprot:RLPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RLPA_ECOLI PSORT-B swissprot:RLPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RLPA_ECOLI PSORT2 swissprot:RLPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RLPA_ECOLI Pfam PF03330 http://pfam.xfam.org/family/PF03330 Pfam PF05036 http://pfam.xfam.org/family/PF05036 Phobius swissprot:RLPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RLPA_ECOLI ProteinModelPortal P10100 http://www.proteinmodelportal.org/query/uniprot/P10100 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19684127 http://www.ncbi.nlm.nih.gov/pubmed/19684127 PubMed 19880599 http://www.ncbi.nlm.nih.gov/pubmed/19880599 PubMed 2644207 http://www.ncbi.nlm.nih.gov/pubmed/2644207 PubMed 3316191 http://www.ncbi.nlm.nih.gov/pubmed/3316191 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_415166 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415166 RefSeq WP_001231430 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001231430 SMR P10100 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P10100 STRING 511145.b0633 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0633&targetmode=cogs STRING COG0797 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0797&targetmode=cogs SUPFAM SSF110997 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF110997 SUPFAM SSF50685 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50685 TIGRFAMs TIGR00413 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00413 UniProtKB RLPA_ECOLI http://www.uniprot.org/uniprot/RLPA_ECOLI UniProtKB-AC P10100 http://www.uniprot.org/uniprot/P10100 charge swissprot:RLPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RLPA_ECOLI eggNOG COG0797 http://eggnogapi.embl.de/nog_data/html/tree/COG0797 eggNOG ENOG4105K6T http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K6T epestfind swissprot:RLPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RLPA_ECOLI garnier swissprot:RLPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RLPA_ECOLI helixturnhelix swissprot:RLPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RLPA_ECOLI hmoment swissprot:RLPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RLPA_ECOLI iep swissprot:RLPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RLPA_ECOLI inforesidue swissprot:RLPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RLPA_ECOLI octanol swissprot:RLPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RLPA_ECOLI pepcoil swissprot:RLPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RLPA_ECOLI pepdigest swissprot:RLPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RLPA_ECOLI pepinfo swissprot:RLPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RLPA_ECOLI pepnet swissprot:RLPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RLPA_ECOLI pepstats swissprot:RLPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RLPA_ECOLI pepwheel swissprot:RLPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RLPA_ECOLI pepwindow swissprot:RLPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RLPA_ECOLI sigcleave swissprot:RLPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RLPA_ECOLI ## Database ID URL or Descriptions # BioGrid 4261424 5 # CDD cd02197 HypE # EcoGene EG10487 hypE # GO_process GO:0046892 peptidyl-S-carbamoyl-L-cysteine dehydration; IDA:EcoCyc. # GO_process GO:0051604 protein maturation; IMP:EcoCyc. # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0051604 protein maturation # Gene3D 3.30.1330.10 -; 1. # Gene3D 3.90.650.10 -; 1. # IntAct P24193 10 # InterPro IPR010918 AIR_synth_C_dom # InterPro IPR011854 HypE # InterPro IPR016188 PurM-like_N # Organism HYPE_ECOLI Escherichia coli (strain K12) # PATRIC 32120860 VBIEscCol129921_2822 # PDB 2I6R X-ray; 2.51 A; A/B/C/D=15-336 # PIR S15201 S15201 # PIRSF PIRSF005644 Hdrgns_mtr_HypE # Pfam PF00586 AIRS # Pfam PF02769 AIRS_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HYPE_ECOLI Hydrogenase isoenzymes formation protein HypE # RefSeq NP_417210 NC_000913.3 # RefSeq WP_001059922 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA69240.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAE76807.1; Type=Erroneous initiation; Evidence={ECO 0000305}; Sequence=CAA38416.1; Type=Erroneous initiation; Evidence={ECO:0000305}; # SIMILARITY Belongs to the HypE family. {ECO 0000305}. # SUPFAM SSF56042 SSF56042 # TIGRFAMs TIGR02124 hypE # eggNOG COG0309 LUCA # eggNOG ENOG4105C45 Bacteria BLAST swissprot:HYPE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HYPE_ECOLI BioCyc ECOL316407:JW2700-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2700-MONOMER BioCyc EcoCyc:EG10487-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10487-MONOMER BioCyc MetaCyc:EG10487-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10487-MONOMER COG COG0309 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0309 DIP DIP-9999N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9999N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1365-2958.1991.tb01833.x http://dx.doi.org/10.1111/j.1365-2958.1991.tb01833.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EMBL X54543 http://www.ebi.ac.uk/ena/data/view/X54543 EchoBASE EB0482 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0482 EcoGene EG10487 http://www.ecogene.org/geneInfo.php?eg_id=EG10487 EnsemblBacteria AAC75772 http://www.ensemblgenomes.org/id/AAC75772 EnsemblBacteria AAC75772 http://www.ensemblgenomes.org/id/AAC75772 EnsemblBacteria BAE76807 http://www.ensemblgenomes.org/id/BAE76807 EnsemblBacteria BAE76807 http://www.ensemblgenomes.org/id/BAE76807 EnsemblBacteria BAE76807 http://www.ensemblgenomes.org/id/BAE76807 EnsemblBacteria b2730 http://www.ensemblgenomes.org/id/b2730 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0046892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046892 GO_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0051604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051604 Gene3D 3.30.1330.10 http://www.cathdb.info/version/latest/superfamily/3.30.1330.10 Gene3D 3.90.650.10 http://www.cathdb.info/version/latest/superfamily/3.90.650.10 GeneID 947182 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947182 HOGENOM HOG000278777 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278777&db=HOGENOM6 InParanoid P24193 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P24193 IntAct P24193 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P24193* InterPro IPR010918 http://www.ebi.ac.uk/interpro/entry/IPR010918 InterPro IPR011854 http://www.ebi.ac.uk/interpro/entry/IPR011854 InterPro IPR016188 http://www.ebi.ac.uk/interpro/entry/IPR016188 KEGG_Gene ecj:JW2700 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2700 KEGG_Gene eco:b2730 http://www.genome.jp/dbget-bin/www_bget?eco:b2730 KEGG_Orthology KO:K04655 http://www.genome.jp/dbget-bin/www_bget?KO:K04655 MINT MINT-1239514 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1239514 PDB 2I6R http://www.ebi.ac.uk/pdbe-srv/view/entry/2I6R PDBsum 2I6R http://www.ebi.ac.uk/pdbsum/2I6R PSORT swissprot:HYPE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HYPE_ECOLI PSORT-B swissprot:HYPE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HYPE_ECOLI PSORT2 swissprot:HYPE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HYPE_ECOLI Pfam PF00586 http://pfam.xfam.org/family/PF00586 Pfam PF02769 http://pfam.xfam.org/family/PF02769 Phobius swissprot:HYPE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HYPE_ECOLI PhylomeDB P24193 http://phylomedb.org/?seqid=P24193 ProteinModelPortal P24193 http://www.proteinmodelportal.org/query/uniprot/P24193 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1849603 http://www.ncbi.nlm.nih.gov/pubmed/1849603 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417210 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417210 RefSeq WP_001059922 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001059922 SMR P24193 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P24193 STRING 511145.b2730 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2730&targetmode=cogs STRING COG0309 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0309&targetmode=cogs SUPFAM SSF56042 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56042 TIGRFAMs TIGR02124 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02124 UniProtKB HYPE_ECOLI http://www.uniprot.org/uniprot/HYPE_ECOLI UniProtKB-AC P24193 http://www.uniprot.org/uniprot/P24193 charge swissprot:HYPE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HYPE_ECOLI eggNOG COG0309 http://eggnogapi.embl.de/nog_data/html/tree/COG0309 eggNOG ENOG4105C45 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C45 epestfind swissprot:HYPE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HYPE_ECOLI garnier swissprot:HYPE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HYPE_ECOLI helixturnhelix swissprot:HYPE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HYPE_ECOLI hmoment swissprot:HYPE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HYPE_ECOLI iep swissprot:HYPE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HYPE_ECOLI inforesidue swissprot:HYPE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HYPE_ECOLI octanol swissprot:HYPE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HYPE_ECOLI pepcoil swissprot:HYPE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HYPE_ECOLI pepdigest swissprot:HYPE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HYPE_ECOLI pepinfo swissprot:HYPE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HYPE_ECOLI pepnet swissprot:HYPE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HYPE_ECOLI pepstats swissprot:HYPE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HYPE_ECOLI pepwheel swissprot:HYPE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HYPE_ECOLI pepwindow swissprot:HYPE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HYPE_ECOLI sigcleave swissprot:HYPE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HYPE_ECOLI ## Database ID URL or Descriptions # BioGrid 4260168 19 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG13369 ynaA # IntAct P77658 5 # InterPro IPR009628 Phage_lambda_GpH_tape_meas_N # Organism YNAA_ECOLI Escherichia coli (strain K12) # PATRIC 48662027 VBIEscCol107702_1377 # PIR T09184 T09184 # Pfam PF06791 TMP_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNAA_ECOLI Putative uncharacterized protein YnaA # RefSeq WP_000840614 NZ_CP014272.1 BLAST swissprot:YNAA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNAA_ECOLI BioCyc ECOL316407:JW1361-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1361-MONOMER BioCyc EcoCyc:G6691-MONOMER http://biocyc.org/getid?id=EcoCyc:G6691-MONOMER DIP DIP-12737N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12737N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3151 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3151 EcoGene EG13369 http://www.ecogene.org/geneInfo.php?eg_id=EG13369 EnsemblBacteria BAA14961 http://www.ensemblgenomes.org/id/BAA14961 EnsemblBacteria BAA14961 http://www.ensemblgenomes.org/id/BAA14961 EnsemblBacteria BAA14961 http://www.ensemblgenomes.org/id/BAA14961 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv HOGENOM HOG000202512 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000202512&db=HOGENOM6 IntAct P77658 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77658* InterPro IPR009628 http://www.ebi.ac.uk/interpro/entry/IPR009628 KEGG_Gene ecj:JW1361 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1361 PSORT swissprot:YNAA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNAA_ECOLI PSORT-B swissprot:YNAA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNAA_ECOLI PSORT2 swissprot:YNAA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNAA_ECOLI Pfam PF06791 http://pfam.xfam.org/family/PF06791 Phobius swissprot:YNAA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNAA_ECOLI ProteinModelPortal P77658 http://www.proteinmodelportal.org/query/uniprot/P77658 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000840614 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000840614 SMR P77658 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77658 STRING 316407.1742228 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.1742228&targetmode=cogs UniProtKB YNAA_ECOLI http://www.uniprot.org/uniprot/YNAA_ECOLI UniProtKB-AC P77658 http://www.uniprot.org/uniprot/P77658 charge swissprot:YNAA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNAA_ECOLI epestfind swissprot:YNAA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNAA_ECOLI garnier swissprot:YNAA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNAA_ECOLI helixturnhelix swissprot:YNAA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNAA_ECOLI hmoment swissprot:YNAA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNAA_ECOLI iep swissprot:YNAA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNAA_ECOLI inforesidue swissprot:YNAA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNAA_ECOLI octanol swissprot:YNAA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNAA_ECOLI pepcoil swissprot:YNAA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNAA_ECOLI pepdigest swissprot:YNAA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNAA_ECOLI pepinfo swissprot:YNAA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNAA_ECOLI pepnet swissprot:YNAA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNAA_ECOLI pepstats swissprot:YNAA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNAA_ECOLI pepwheel swissprot:YNAA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNAA_ECOLI pepwindow swissprot:YNAA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNAA_ECOLI sigcleave swissprot:YNAA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNAA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259614 339 # CATALYTIC ACTIVITY GLPA_ECOLI sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol. # COFACTOR Name=FAD; Xref=ChEBI:CHEBI 57692; # COFACTOR Name=FMN; Xref=ChEBI:CHEBI 58210; # EcoGene EG10391 glpA # FUNCTION GLPA_ECOLI Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0009331 glycerol-3-phosphate dehydrogenase complex; IEA:InterPro. # GO_function GLPA_ECOLI GO 0052591 sn-glycerol-3-phosphate ubiquinone-8 oxidoreductase activity; IEA UniProtKB-EC. # GO_function GO:0004368 glycerol-3-phosphate dehydrogenase activity; IDA:EcoCyc. # GO_function GO:0010181 FMN binding; IEA:InterPro. # GO_function GO:0050660 flavin adenine dinucleotide binding; IDA:EcoCyc. # GO_process GO:0009061 anaerobic respiration; IEP:EcoCyc. # GO_process GO:0019563 glycerol catabolic process; IEA:UniProtKB-UniPathway. # GO_process GO:0046168 glycerol-3-phosphate catabolic process; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006091 generation of precursor metabolites and energy # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.50.50.60 -; 1. # IntAct P0A9C0 4 # InterPro IPR000447 G3P_DH_FAD-dep # InterPro IPR006076 FAD-dep_OxRdtase # InterPro IPR007419 BFD-like_2Fe2S-bd_dom # InterPro IPR017752 G3P_DH_GlpA_su # InterPro IPR023753 FAD/NAD-binding_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00564 Glycerophospholipid metabolism # Organism GLPA_ECOLI Escherichia coli (strain K12) # PATHWAY Polyol metabolism; glycerol degradation via glycerol kinase pathway; glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route) step 1/1. # PATRIC 32119841 VBIEscCol129921_2330 # PIR A32006 DEECNA # PRINTS PR01001 FADG3PDH # PROSITE PS00977 FAD_G3PDH_1 # PROSITE PS00978 FAD_G3PDH_2 # Pfam PF01266 DAO # Pfam PF04324 Fer2_BFD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLPA_ECOLI Anaerobic glycerol-3-phosphate dehydrogenase subunit A # RefSeq NP_416744 NC_000913.3 # RefSeq WP_000857257 NZ_LN832404.1 # SIMILARITY Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. {ECO 0000305}. # SUBCELLULAR LOCATION GLPA_ECOLI Cell inner membrane; Peripheral membrane protein. Note=Loosely bound to the cytoplasmic membrane often occurring in vesicles associated with fumarate reductase. # SUBUNIT GLPA_ECOLI Composed of a catalytic GlpA/B dimer and of membrane bound GlpC. # SUPFAM SSF51905 SSF51905 # TIGRFAMs TIGR03377 glycerol3P_GlpA # UniPathway UPA00618 UER00673 # eggNOG COG0578 LUCA # eggNOG ENOG4107R5Y Bacteria BLAST swissprot:GLPA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLPA_ECOLI BioCyc ECOL316407:JW2235-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2235-MONOMER BioCyc EcoCyc:ANGLYC3PDEHYDROGSUBUNITA-MONOMER http://biocyc.org/getid?id=EcoCyc:ANGLYC3PDEHYDROGSUBUNITA-MONOMER BioCyc MetaCyc:ANGLYC3PDEHYDROGSUBUNITA-MONOMER http://biocyc.org/getid?id=MetaCyc:ANGLYC3PDEHYDROGSUBUNITA-MONOMER COG COG0578 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0578 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.5.3 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.5.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M20938 http://www.ebi.ac.uk/ena/data/view/M20938 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.1.5.3 http://enzyme.expasy.org/EC/1.1.5.3 EchoBASE EB0386 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0386 EcoGene EG10391 http://www.ecogene.org/geneInfo.php?eg_id=EG10391 EnsemblBacteria AAC75301 http://www.ensemblgenomes.org/id/AAC75301 EnsemblBacteria AAC75301 http://www.ensemblgenomes.org/id/AAC75301 EnsemblBacteria BAA16060 http://www.ensemblgenomes.org/id/BAA16060 EnsemblBacteria BAA16060 http://www.ensemblgenomes.org/id/BAA16060 EnsemblBacteria BAA16060 http://www.ensemblgenomes.org/id/BAA16060 EnsemblBacteria b2241 http://www.ensemblgenomes.org/id/b2241 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0009331 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009331 GO_function GO:0004368 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004368 GO_function GO:0010181 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010181 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_function GO:0052591 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052591 GO_process GO:0009061 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009061 GO_process GO:0019563 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019563 GO_process GO:0046168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046168 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 GeneID 946713 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946713 HOGENOM HOG000004814 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000004814&db=HOGENOM6 InParanoid P0A9C0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9C0 IntAct P0A9C0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9C0* IntEnz 1.1.5.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.5.3 InterPro IPR000447 http://www.ebi.ac.uk/interpro/entry/IPR000447 InterPro IPR006076 http://www.ebi.ac.uk/interpro/entry/IPR006076 InterPro IPR007419 http://www.ebi.ac.uk/interpro/entry/IPR007419 InterPro IPR017752 http://www.ebi.ac.uk/interpro/entry/IPR017752 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2235 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2235 KEGG_Gene eco:b2241 http://www.genome.jp/dbget-bin/www_bget?eco:b2241 KEGG_Orthology KO:K00111 http://www.genome.jp/dbget-bin/www_bget?KO:K00111 KEGG_Pathway ko00564 http://www.genome.jp/kegg-bin/show_pathway?ko00564 KEGG_Reaction rn:R00848 http://www.genome.jp/dbget-bin/www_bget?rn:R00848 OMA MEGFITI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MEGFITI PRINTS PR01001 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01001 PROSITE PS00977 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00977 PROSITE PS00978 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00978 PSORT swissprot:GLPA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLPA_ECOLI PSORT-B swissprot:GLPA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLPA_ECOLI PSORT2 swissprot:GLPA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLPA_ECOLI Pfam PF01266 http://pfam.xfam.org/family/PF01266 Pfam PF04324 http://pfam.xfam.org/family/PF04324 Phobius swissprot:GLPA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLPA_ECOLI PhylomeDB P0A9C0 http://phylomedb.org/?seqid=P0A9C0 ProteinModelPortal P0A9C0 http://www.proteinmodelportal.org/query/uniprot/P0A9C0 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3286606 http://www.ncbi.nlm.nih.gov/pubmed/3286606 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416744 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416744 RefSeq WP_000857257 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000857257 SMR P0A9C0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9C0 STRING 511145.b2241 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2241&targetmode=cogs STRING COG0578 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0578&targetmode=cogs SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 TIGRFAMs TIGR03377 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03377 UniProtKB GLPA_ECOLI http://www.uniprot.org/uniprot/GLPA_ECOLI UniProtKB-AC P0A9C0 http://www.uniprot.org/uniprot/P0A9C0 charge swissprot:GLPA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLPA_ECOLI eggNOG COG0578 http://eggnogapi.embl.de/nog_data/html/tree/COG0578 eggNOG ENOG4107R5Y http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107R5Y epestfind swissprot:GLPA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLPA_ECOLI garnier swissprot:GLPA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLPA_ECOLI helixturnhelix swissprot:GLPA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLPA_ECOLI hmoment swissprot:GLPA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLPA_ECOLI iep swissprot:GLPA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLPA_ECOLI inforesidue swissprot:GLPA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLPA_ECOLI octanol swissprot:GLPA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLPA_ECOLI pepcoil swissprot:GLPA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLPA_ECOLI pepdigest swissprot:GLPA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLPA_ECOLI pepinfo swissprot:GLPA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLPA_ECOLI pepnet swissprot:GLPA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLPA_ECOLI pepstats swissprot:GLPA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLPA_ECOLI pepwheel swissprot:GLPA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLPA_ECOLI pepwindow swissprot:GLPA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLPA_ECOLI sigcleave swissprot:GLPA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLPA_ECOLI ## Database ID URL or Descriptions # AltName GLPF_ECOLI Aquaglyceroporin # BioGrid 4263410 157 # CDD cd00333 MIP # COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI 18420; Note=Binds 2 magnesium ions per subunit.; # DOMAIN GLPF_ECOLI Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). # EcoGene EG10396 glpF # FUNCTION GLPF_ECOLI Transporter of glycerol across the cytoplasmic membrane, with limited permeability to water and small uncharged compounds such as polyols. # GO_component GO:0005886 plasma membrane; IDA:UniProtKB. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0015168 glycerol transmembrane transporter activity; IDA:UniProtKB. # GO_function GO:0015250 water channel activity; IBA:GO_Central. # GO_function GO:0015254 glycerol channel activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0009992 cellular water homeostasis; IBA:GO_Central. # GO_process GO:0015793 glycerol transport; IDA:UniProtKB. # GO_process GO:0034220 ion transmembrane transport; IBA:GO_Central. # GO_process GO:0071288 cellular response to mercury ion; IDA:UniProtKB. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # GOslim_process GO:0042592 homeostatic process # GOslim_process GO:0055085 transmembrane transport # Gene3D 1.20.1080.10 -; 1. # InterPro IPR000425 MIP # InterPro IPR022357 MIP_CS # InterPro IPR023271 Aquaporin-like # KEGG_Brite ko04040 Ion channels # MISCELLANEOUS GLPF_ECOLI The remarkable property of effective water conductance combined with a strict exclusion of all ions including protons is mediated by two conserved asparagines which force a central water molecule to serve strictly as a hydrogen bond donor to its neighboring water molecules. Assisted by the electrostatic potential generated by two half-membrane spanning loops, this dictates opposite orientations of water molecules in the two halves of the channel, and thus prevents the formation of a "proton wire", while permitting rapid water diffusion. # Organism GLPF_ECOLI Escherichia coli (strain K12) # PANTHER PTHR19139 PTHR19139 # PATRIC 32123367 VBIEscCol129921_4044 # PDB 1FX8 X-ray; 2.20 A; A=1-281 # PDB 1LDA X-ray; 2.80 A; A=1-281 # PDB 1LDF X-ray; 2.10 A; A=1-281 # PDB 1LDI X-ray; 2.70 A; A=1-281 # PIR A42157 XMECGF # PRINTS PR00783 MINTRINSICP # PROSITE PS00221 MIP # Pfam PF00230 MIP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GLPF_ECOLI Glycerol uptake facilitator protein # RefSeq NP_418362 NC_000913.3 # RefSeq WP_000084268 NZ_LN832404.1 # SIMILARITY Belongs to the MIP/aquaporin (TC 1.A.8) family. {ECO 0000305}. # SUBCELLULAR LOCATION GLPF_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # SUBUNIT Homotetramer. {ECO 0000305}. # SUPFAM SSF81338 SSF81338 # TCDB 1.A.8.1 the major intrinsic protein (mip) family # TIGRFAMs TIGR00861 MIP # eggNOG COG0580 LUCA # eggNOG ENOG4105D8C Bacteria BLAST swissprot:GLPF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLPF_ECOLI BioCyc ECOL316407:JW3898-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3898-MONOMER BioCyc EcoCyc:GLPF-MONOMER http://biocyc.org/getid?id=EcoCyc:GLPF-MONOMER BioCyc MetaCyc:GLPF-MONOMER http://biocyc.org/getid?id=MetaCyc:GLPF-MONOMER COG COG0580 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0580 DIP DIP-47976N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47976N DOI 10.1038/81914 http://dx.doi.org/10.1038/81914 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.051628098 http://dx.doi.org/10.1073/pnas.051628098 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1126/science.1067778 http://dx.doi.org/10.1126/science.1067778 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1126/science.290.5491.481 http://dx.doi.org/10.1126/science.290.5491.481 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL M55990 http://www.ebi.ac.uk/ena/data/view/M55990 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U13915 http://www.ebi.ac.uk/ena/data/view/U13915 EMBL X15054 http://www.ebi.ac.uk/ena/data/view/X15054 EchoBASE EB0391 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0391 EcoGene EG10396 http://www.ecogene.org/geneInfo.php?eg_id=EG10396 EnsemblBacteria AAC76909 http://www.ensemblgenomes.org/id/AAC76909 EnsemblBacteria AAC76909 http://www.ensemblgenomes.org/id/AAC76909 EnsemblBacteria BAE77383 http://www.ensemblgenomes.org/id/BAE77383 EnsemblBacteria BAE77383 http://www.ensemblgenomes.org/id/BAE77383 EnsemblBacteria BAE77383 http://www.ensemblgenomes.org/id/BAE77383 EnsemblBacteria b3927 http://www.ensemblgenomes.org/id/b3927 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015168 GO_function GO:0015250 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015250 GO_function GO:0015254 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015254 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0009992 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009992 GO_process GO:0015793 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015793 GO_process GO:0034220 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034220 GO_process GO:0071288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071288 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 1.20.1080.10 http://www.cathdb.info/version/latest/superfamily/1.20.1080.10 GeneID 948422 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948422 HOGENOM HOG000288287 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000288287&db=HOGENOM6 InParanoid P0AER0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AER0 IntAct P0AER0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AER0* InterPro IPR000425 http://www.ebi.ac.uk/interpro/entry/IPR000425 InterPro IPR022357 http://www.ebi.ac.uk/interpro/entry/IPR022357 InterPro IPR023271 http://www.ebi.ac.uk/interpro/entry/IPR023271 KEGG_Brite ko04040 http://www.genome.jp/dbget-bin/www_bget?ko04040 KEGG_Gene ecj:JW3898 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3898 KEGG_Gene eco:b3927 http://www.genome.jp/dbget-bin/www_bget?eco:b3927 KEGG_Orthology KO:K02440 http://www.genome.jp/dbget-bin/www_bget?KO:K02440 MINT MINT-1256193 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1256193 OMA AREIPYF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AREIPYF PANTHER PTHR19139 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19139 PDB 1FX8 http://www.ebi.ac.uk/pdbe-srv/view/entry/1FX8 PDB 1LDA http://www.ebi.ac.uk/pdbe-srv/view/entry/1LDA PDB 1LDF http://www.ebi.ac.uk/pdbe-srv/view/entry/1LDF PDB 1LDI http://www.ebi.ac.uk/pdbe-srv/view/entry/1LDI PDBsum 1FX8 http://www.ebi.ac.uk/pdbsum/1FX8 PDBsum 1LDA http://www.ebi.ac.uk/pdbsum/1LDA PDBsum 1LDF http://www.ebi.ac.uk/pdbsum/1LDF PDBsum 1LDI http://www.ebi.ac.uk/pdbsum/1LDI PRINTS PR00783 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00783 PROSITE PS00221 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00221 PSORT swissprot:GLPF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLPF_ECOLI PSORT-B swissprot:GLPF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLPF_ECOLI PSORT2 swissprot:GLPF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLPF_ECOLI Pfam PF00230 http://pfam.xfam.org/family/PF00230 Phobius swissprot:GLPF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLPF_ECOLI PhylomeDB P0AER0 http://phylomedb.org/?seqid=P0AER0 ProteinModelPortal P0AER0 http://www.proteinmodelportal.org/query/uniprot/P0AER0 PubMed 11039922 http://www.ncbi.nlm.nih.gov/pubmed/11039922 PubMed 11101882 http://www.ncbi.nlm.nih.gov/pubmed/11101882 PubMed 11226336 http://www.ncbi.nlm.nih.gov/pubmed/11226336 PubMed 11964478 http://www.ncbi.nlm.nih.gov/pubmed/11964478 PubMed 1372899 http://www.ncbi.nlm.nih.gov/pubmed/1372899 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2544860 http://www.ncbi.nlm.nih.gov/pubmed/2544860 PubMed 6998951 http://www.ncbi.nlm.nih.gov/pubmed/6998951 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418362 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418362 RefSeq WP_000084268 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000084268 SMR P0AER0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AER0 STRING 511145.b3927 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3927&targetmode=cogs STRING COG0580 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0580&targetmode=cogs SUPFAM SSF81338 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81338 TCDB 1.A.8.1 http://www.tcdb.org/search/result.php?tc=1.A.8.1 TIGRFAMs TIGR00861 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00861 UniProtKB GLPF_ECOLI http://www.uniprot.org/uniprot/GLPF_ECOLI UniProtKB-AC P0AER0 http://www.uniprot.org/uniprot/P0AER0 charge swissprot:GLPF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLPF_ECOLI eggNOG COG0580 http://eggnogapi.embl.de/nog_data/html/tree/COG0580 eggNOG ENOG4105D8C http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D8C epestfind swissprot:GLPF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLPF_ECOLI garnier swissprot:GLPF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLPF_ECOLI helixturnhelix swissprot:GLPF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLPF_ECOLI hmoment swissprot:GLPF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLPF_ECOLI iep swissprot:GLPF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLPF_ECOLI inforesidue swissprot:GLPF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLPF_ECOLI octanol swissprot:GLPF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLPF_ECOLI pepcoil swissprot:GLPF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLPF_ECOLI pepdigest swissprot:GLPF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLPF_ECOLI pepinfo swissprot:GLPF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLPF_ECOLI pepnet swissprot:GLPF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLPF_ECOLI pepstats swissprot:GLPF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLPF_ECOLI pepwheel swissprot:GLPF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLPF_ECOLI pepwindow swissprot:GLPF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLPF_ECOLI sigcleave swissprot:GLPF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLPF_ECOLI ## Database ID URL or Descriptions # BioGrid 4260164 68 # EcoGene EG10813 racC # IntAct P15033 11 # Organism RACC_ECOLI Escherichia coli (strain K12) # PATRIC 32117980 VBIEscCol129921_1410 # PIR JS0119 BVECAC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RACC_ECOLI Protein RacC # RefSeq NP_415867 NC_000913.3 # RefSeq WP_000632297 NZ_CP014272.1 BLAST swissprot:RACC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RACC_ECOLI BioCyc ECOL316407:JW1345-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1345-MONOMER BioCyc EcoCyc:EG10813-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10813-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M24905 http://www.ebi.ac.uk/ena/data/view/M24905 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0806 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0806 EcoGene EG10813 http://www.ecogene.org/geneInfo.php?eg_id=EG10813 EnsemblBacteria AAC74433 http://www.ensemblgenomes.org/id/AAC74433 EnsemblBacteria AAC74433 http://www.ensemblgenomes.org/id/AAC74433 EnsemblBacteria BAA14953 http://www.ensemblgenomes.org/id/BAA14953 EnsemblBacteria BAA14953 http://www.ensemblgenomes.org/id/BAA14953 EnsemblBacteria BAA14953 http://www.ensemblgenomes.org/id/BAA14953 EnsemblBacteria b1351 http://www.ensemblgenomes.org/id/b1351 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945920 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945920 HOGENOM HOG000120176 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000120176&db=HOGENOM6 IntAct P15033 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P15033* KEGG_Gene ecj:JW1345 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1345 KEGG_Gene eco:b1351 http://www.genome.jp/dbget-bin/www_bget?eco:b1351 OMA NMITNYE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NMITNYE PSORT swissprot:RACC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RACC_ECOLI PSORT-B swissprot:RACC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RACC_ECOLI PSORT2 swissprot:RACC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RACC_ECOLI Phobius swissprot:RACC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RACC_ECOLI ProteinModelPortal P15033 http://www.proteinmodelportal.org/query/uniprot/P15033 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2649487 http://www.ncbi.nlm.nih.gov/pubmed/2649487 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415867 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415867 RefSeq WP_000632297 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000632297 SMR P15033 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P15033 STRING 511145.b1351 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1351&targetmode=cogs UniProtKB RACC_ECOLI http://www.uniprot.org/uniprot/RACC_ECOLI UniProtKB-AC P15033 http://www.uniprot.org/uniprot/P15033 charge swissprot:RACC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RACC_ECOLI epestfind swissprot:RACC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RACC_ECOLI garnier swissprot:RACC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RACC_ECOLI helixturnhelix swissprot:RACC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RACC_ECOLI hmoment swissprot:RACC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RACC_ECOLI iep swissprot:RACC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RACC_ECOLI inforesidue swissprot:RACC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RACC_ECOLI octanol swissprot:RACC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RACC_ECOLI pepcoil swissprot:RACC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RACC_ECOLI pepdigest swissprot:RACC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RACC_ECOLI pepinfo swissprot:RACC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RACC_ECOLI pepnet swissprot:RACC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RACC_ECOLI pepstats swissprot:RACC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RACC_ECOLI pepwheel swissprot:RACC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RACC_ECOLI pepwindow swissprot:RACC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RACC_ECOLI sigcleave swissprot:RACC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RACC_ECOLI ## Database ID URL or Descriptions # BioGrid 4262089 122 # EcoGene EG12919 yhfX # Gene3D 3.20.20.10 -; 1. # IntAct P45550 2 # InterPro IPR001608 Ala_racemase_N # InterPro IPR029066 PLP-binding_barrel # Organism YHFX_ECOLI Escherichia coli (strain K12) # PATRIC 32122194 VBIEscCol129921_3474 # PDB 4KBX X-ray; 1.60 A; A=2-387 # PIR H65132 H65132 # Pfam PF01168 Ala_racemase_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHFX_ECOLI Uncharacterized protein YhfX # RefSeq NP_417840 NC_000913.3 # RefSeq WP_000497334 NZ_LN832404.1 # SUPFAM SSF51419 SSF51419 # eggNOG COG3457 LUCA # eggNOG ENOG4108626 Bacteria BLAST swissprot:YHFX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHFX_ECOLI BioCyc ECOL316407:JW3344-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3344-MONOMER BioCyc EcoCyc:G7733-MONOMER http://biocyc.org/getid?id=EcoCyc:G7733-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2755 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2755 EcoGene EG12919 http://www.ecogene.org/geneInfo.php?eg_id=EG12919 EnsemblBacteria AAC76406 http://www.ensemblgenomes.org/id/AAC76406 EnsemblBacteria AAC76406 http://www.ensemblgenomes.org/id/AAC76406 EnsemblBacteria BAE77910 http://www.ensemblgenomes.org/id/BAE77910 EnsemblBacteria BAE77910 http://www.ensemblgenomes.org/id/BAE77910 EnsemblBacteria BAE77910 http://www.ensemblgenomes.org/id/BAE77910 EnsemblBacteria b3381 http://www.ensemblgenomes.org/id/b3381 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.20.20.10 http://www.cathdb.info/version/latest/superfamily/3.20.20.10 GeneID 947889 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947889 HOGENOM HOG000125475 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125475&db=HOGENOM6 IntAct P45550 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45550* InterPro IPR001608 http://www.ebi.ac.uk/interpro/entry/IPR001608 InterPro IPR029066 http://www.ebi.ac.uk/interpro/entry/IPR029066 KEGG_Gene ecj:JW3344 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3344 KEGG_Gene eco:b3381 http://www.genome.jp/dbget-bin/www_bget?eco:b3381 OMA MTKQVGR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MTKQVGR PDB 4KBX http://www.ebi.ac.uk/pdbe-srv/view/entry/4KBX PDBsum 4KBX http://www.ebi.ac.uk/pdbsum/4KBX PSORT swissprot:YHFX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHFX_ECOLI PSORT-B swissprot:YHFX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHFX_ECOLI PSORT2 swissprot:YHFX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHFX_ECOLI Pfam PF01168 http://pfam.xfam.org/family/PF01168 Phobius swissprot:YHFX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHFX_ECOLI ProteinModelPortal P45550 http://www.proteinmodelportal.org/query/uniprot/P45550 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417840 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417840 RefSeq WP_000497334 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000497334 SMR P45550 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45550 STRING 511145.b3381 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3381&targetmode=cogs SUPFAM SSF51419 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51419 UniProtKB YHFX_ECOLI http://www.uniprot.org/uniprot/YHFX_ECOLI UniProtKB-AC P45550 http://www.uniprot.org/uniprot/P45550 charge swissprot:YHFX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHFX_ECOLI eggNOG COG3457 http://eggnogapi.embl.de/nog_data/html/tree/COG3457 eggNOG ENOG4108626 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108626 epestfind swissprot:YHFX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHFX_ECOLI garnier swissprot:YHFX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHFX_ECOLI helixturnhelix swissprot:YHFX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHFX_ECOLI hmoment swissprot:YHFX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHFX_ECOLI iep swissprot:YHFX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHFX_ECOLI inforesidue swissprot:YHFX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHFX_ECOLI octanol swissprot:YHFX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHFX_ECOLI pepcoil swissprot:YHFX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHFX_ECOLI pepdigest swissprot:YHFX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHFX_ECOLI pepinfo swissprot:YHFX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHFX_ECOLI pepnet swissprot:YHFX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHFX_ECOLI pepstats swissprot:YHFX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHFX_ECOLI pepwheel swissprot:YHFX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHFX_ECOLI pepwindow swissprot:YHFX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHFX_ECOLI sigcleave swissprot:YHFX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHFX_ECOLI ## Database ID URL or Descriptions # AltName L-ascorbate utilization protein E {ECO:0000255|HAMAP-Rule MF_01951} # AltName L-xylulose-5-phosphate 3-epimerase {ECO:0000255|HAMAP-Rule MF_01951} # BioGrid 4262715 7 # CATALYTIC ACTIVITY L-ribulose 5-phosphate = L-xylulose 5- phosphate. {ECO:0000255|HAMAP-Rule MF_01951}. # EcoGene EG12497 ulaE # FUNCTION ULAE_ECOLI Catalyzes the isomerization of L-xylulose-5-phosphate to L-ribulose-5-phosphate. Is involved in the anaerobic L-ascorbate utilization. {ECO 0000255|HAMAP-Rule MF_01951, ECO 0000269|PubMed 11741871}. # GO_function GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses; IEA:InterPro. # GO_function GO:0034015 L-ribulose-5-phosphate 3-epimerase activity; IDA:EcoCyc. # GO_process GO:0005975 carbohydrate metabolic process; IEA:InterPro. # GO_process GO:0019852 L-ascorbic acid metabolic process; IEP:EcoCyc. # GO_process GO:0019854 L-ascorbic acid catabolic process; IEA:UniProtKB-UniPathway. # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.150 -; 1. # HAMAP MF_01951 UlaE # INDUCTION ULAE_ECOLI Induced by L-ascorbate. Repressed by UlaR. {ECO 0000255|HAMAP-Rule MF_01951, ECO 0000269|PubMed 12374842, ECO 0000269|PubMed 14996803}. # InterPro IPR004560 L-Ru-5P_3-Epase # InterPro IPR013022 Xyl_isomerase-like_TIM-brl # InterPro IPR023492 L-Ru-5P_3-Epase_Enterobacteria # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00053 Ascorbate and aldarate metabolism # Organism ULAE_ECOLI Escherichia coli (strain K12) # PATHWAY Cofactor degradation; L-ascorbate degradation; D-xylulose 5-phosphate from L-ascorbate: step 3/4. {ECO 0000255|HAMAP- Rule:MF_01951}. # PATRIC 32123969 VBIEscCol129921_4329 # PIR S56422 S56422 # Pfam PF01261 AP_endonuc_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName L-ribulose-5-phosphate 3-epimerase UlaE {ECO:0000255|HAMAP-Rule MF_01951} # RefSeq NP_418618 NC_000913.3 # RefSeq WP_000949502 NZ_LN832404.1 # SIMILARITY Belongs to the L-ribulose-5-phosphate 3-epimerase family. {ECO:0000255|HAMAP-Rule MF_01951}. # SUPFAM SSF51658 SSF51658 # TIGRFAMs TIGR00542 hxl6Piso_put # UniPathway UPA00263 UER00379 # eggNOG COG3623 LUCA # eggNOG ENOG41064BZ Bacteria BLAST swissprot:ULAE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ULAE_ECOLI BioCyc ECOL316407:JW4155-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4155-MONOMER BioCyc EcoCyc:G7859-MONOMER http://biocyc.org/getid?id=EcoCyc:G7859-MONOMER BioCyc MetaCyc:G7859-MONOMER http://biocyc.org/getid?id=MetaCyc:G7859-MONOMER COG COG3623 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3623 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.1.302-306.2002 http://dx.doi.org/10.1128/JB.184.1.302-306.2002 DOI 10.1128/JB.184.21.6065-6068.2002 http://dx.doi.org/10.1128/JB.184.21.6065-6068.2002 DOI 10.1128/JB.186.6.1720-1728.2004 http://dx.doi.org/10.1128/JB.186.6.1720-1728.2004 EC_number EC:5.1.3.22 {ECO:0000255|HAMAP-Rule:MF_01951} http://www.genome.jp/dbget-bin/www_bget?EC:5.1.3.22 {ECO:0000255|HAMAP-Rule:MF_01951} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 ENZYME 5.1.3.22 {ECO:0000255|HAMAP-Rule:MF_01951} http://enzyme.expasy.org/EC/5.1.3.22 {ECO:0000255|HAMAP-Rule:MF_01951} EchoBASE EB2390 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2390 EcoGene EG12497 http://www.ecogene.org/geneInfo.php?eg_id=EG12497 EnsemblBacteria AAC77154 http://www.ensemblgenomes.org/id/AAC77154 EnsemblBacteria AAC77154 http://www.ensemblgenomes.org/id/AAC77154 EnsemblBacteria BAE78198 http://www.ensemblgenomes.org/id/BAE78198 EnsemblBacteria BAE78198 http://www.ensemblgenomes.org/id/BAE78198 EnsemblBacteria BAE78198 http://www.ensemblgenomes.org/id/BAE78198 EnsemblBacteria b4197 http://www.ensemblgenomes.org/id/b4197 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016861 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016861 GO_function GO:0034015 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034015 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GO_process GO:0019852 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019852 GO_process GO:0019854 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019854 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.150 http://www.cathdb.info/version/latest/superfamily/3.20.20.150 GeneID 948712 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948712 HAMAP MF_01951 http://hamap.expasy.org/unirule/MF_01951 HOGENOM HOG000126090 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000126090&db=HOGENOM6 InParanoid P39305 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39305 IntAct P39305 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39305* IntEnz 5.1.3.22 {ECO:0000255|HAMAP-Rule:MF_01951} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.1.3.22 {ECO:0000255|HAMAP-Rule:MF_01951} InterPro IPR004560 http://www.ebi.ac.uk/interpro/entry/IPR004560 InterPro IPR013022 http://www.ebi.ac.uk/interpro/entry/IPR013022 InterPro IPR023492 http://www.ebi.ac.uk/interpro/entry/IPR023492 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4155 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4155 KEGG_Gene eco:b4197 http://www.genome.jp/dbget-bin/www_bget?eco:b4197 KEGG_Orthology KO:K03079 http://www.genome.jp/dbget-bin/www_bget?KO:K03079 KEGG_Pathway ko00053 http://www.genome.jp/kegg-bin/show_pathway?ko00053 KEGG_Reaction rn:R03244 http://www.genome.jp/dbget-bin/www_bget?rn:R03244 OMA QAGMGHI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QAGMGHI PSORT swissprot:ULAE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ULAE_ECOLI PSORT-B swissprot:ULAE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ULAE_ECOLI PSORT2 swissprot:ULAE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ULAE_ECOLI Pfam PF01261 http://pfam.xfam.org/family/PF01261 Phobius swissprot:ULAE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ULAE_ECOLI PhylomeDB P39305 http://phylomedb.org/?seqid=P39305 ProteinModelPortal P39305 http://www.proteinmodelportal.org/query/uniprot/P39305 PubMed 11741871 http://www.ncbi.nlm.nih.gov/pubmed/11741871 PubMed 12374842 http://www.ncbi.nlm.nih.gov/pubmed/12374842 PubMed 14996803 http://www.ncbi.nlm.nih.gov/pubmed/14996803 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418618 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418618 RefSeq WP_000949502 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000949502 SMR P39305 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P39305 STRING 511145.b4197 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4197&targetmode=cogs STRING COG3623 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3623&targetmode=cogs SUPFAM SSF51658 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51658 TIGRFAMs TIGR00542 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00542 UniProtKB ULAE_ECOLI http://www.uniprot.org/uniprot/ULAE_ECOLI UniProtKB-AC P39305 http://www.uniprot.org/uniprot/P39305 charge swissprot:ULAE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ULAE_ECOLI eggNOG COG3623 http://eggnogapi.embl.de/nog_data/html/tree/COG3623 eggNOG ENOG41064BZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG41064BZ epestfind swissprot:ULAE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ULAE_ECOLI garnier swissprot:ULAE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ULAE_ECOLI helixturnhelix swissprot:ULAE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ULAE_ECOLI hmoment swissprot:ULAE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ULAE_ECOLI iep swissprot:ULAE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ULAE_ECOLI inforesidue swissprot:ULAE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ULAE_ECOLI octanol swissprot:ULAE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ULAE_ECOLI pepcoil swissprot:ULAE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ULAE_ECOLI pepdigest swissprot:ULAE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ULAE_ECOLI pepinfo swissprot:ULAE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ULAE_ECOLI pepnet swissprot:ULAE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ULAE_ECOLI pepstats swissprot:ULAE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ULAE_ECOLI pepwheel swissprot:ULAE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ULAE_ECOLI pepwindow swissprot:ULAE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ULAE_ECOLI sigcleave swissprot:ULAE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ULAE_ECOLI ## Database ID URL or Descriptions # AltName RIBF_ECOLI FAD pyrophosphorylase # AltName RIBF_ECOLI FAD synthase # AltName RIBF_ECOLI Flavokinase # AltName RIBF_ECOLI Flavokinase # BioGrid 4261848 3 # CATALYTIC ACTIVITY RIBF_ECOLI ATP + FMN = diphosphate + FAD. # CATALYTIC ACTIVITY RIBF_ECOLI ATP + riboflavin = ADP + FMN. # EcoGene EG11079 ribF # GO_function GO:0003919 FMN adenylyltransferase activity; IGI:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0008531 riboflavin kinase activity; IGI:EcoCyc. # GO_process GO:0006747 FAD biosynthetic process; IEA:UniProtKB-UniPathway. # GO_process GO:0009231 riboflavin biosynthetic process; IEA:InterPro. # GO_process GO:0009398 FMN biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 2.40.30.30 -; 1. # Gene3D 3.40.50.620 -; 1. # IntAct P0AG40 10 # InterPro IPR002606 Riboflavin_kinase_bac # InterPro IPR014729 Rossmann-like_a/b/a_fold # InterPro IPR015864 FAD_synthase # InterPro IPR015865 Riboflavin_kinase_bac/euk # InterPro IPR023465 Riboflavin_kinase_domain # InterPro IPR023468 Riboflavin_kinase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00740 Riboflavin metabolism # Organism RIBF_ECOLI Escherichia coli (strain K12) # PANTHER PTHR22749 PTHR22749 # PATHWAY Cofactor biosynthesis; FAD biosynthesis; FAD from FMN step 1/1. # PATHWAY Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route) step 1/1. # PATRIC 32115141 VBIEscCol129921_0022 # PIR A64723 QQECIL # PIRSF PIRSF004491 FAD_Synth # Pfam PF01687 Flavokinase # Pfam PF06574 FAD_syn # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RIBF_ECOLI FMN adenylyltransferase # RecName RIBF_ECOLI Riboflavin biosynthesis protein RibF # RecName RIBF_ECOLI Riboflavin biosynthesis protein RibF # RecName RIBF_ECOLI Riboflavin kinase # RefSeq NP_414566 NC_000913.3 # RefSeq WP_000767329 NZ_LN832404.1 # SIMILARITY Belongs to the RibF family. {ECO 0000305}. # SMART SM00904 Flavokinase # SUPFAM SSF82114 SSF82114 # TIGRFAMs TIGR00083 ribF # UniPathway UPA00276 UER00406 # UniPathway UPA00277 UER00407 # eggNOG COG0196 LUCA # eggNOG ENOG4105DTN Bacteria BLAST swissprot:RIBF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RIBF_ECOLI BioCyc ECOL316407:JW0023-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0023-MONOMER BioCyc EcoCyc:RIBF-MONOMER http://biocyc.org/getid?id=EcoCyc:RIBF-MONOMER BioCyc MetaCyc:RIBF-MONOMER http://biocyc.org/getid?id=MetaCyc:RIBF-MONOMER COG COG0196 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0196 DIP DIP-35789N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35789N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.26 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.26 EC_number EC:2.7.7.2 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M10428 http://www.ebi.ac.uk/ena/data/view/M10428 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.26 http://enzyme.expasy.org/EC/2.7.1.26 ENZYME 2.7.7.2 http://enzyme.expasy.org/EC/2.7.7.2 EchoBASE EB1071 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1071 EcoGene EG11079 http://www.ecogene.org/geneInfo.php?eg_id=EG11079 EnsemblBacteria AAC73136 http://www.ensemblgenomes.org/id/AAC73136 EnsemblBacteria AAC73136 http://www.ensemblgenomes.org/id/AAC73136 EnsemblBacteria BAB96594 http://www.ensemblgenomes.org/id/BAB96594 EnsemblBacteria BAB96594 http://www.ensemblgenomes.org/id/BAB96594 EnsemblBacteria BAB96594 http://www.ensemblgenomes.org/id/BAB96594 EnsemblBacteria b0025 http://www.ensemblgenomes.org/id/b0025 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003919 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003919 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008531 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008531 GO_process GO:0006747 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006747 GO_process GO:0009231 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009231 GO_process GO:0009398 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009398 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 2.40.30.30 http://www.cathdb.info/version/latest/superfamily/2.40.30.30 Gene3D 3.40.50.620 http://www.cathdb.info/version/latest/superfamily/3.40.50.620 GeneID 949129 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949129 HOGENOM HOG000006845 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006845&db=HOGENOM6 InParanoid P0AG40 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AG40 IntAct P0AG40 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AG40* IntEnz 2.7.1.26 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.26 IntEnz 2.7.7.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.2 InterPro IPR002606 http://www.ebi.ac.uk/interpro/entry/IPR002606 InterPro IPR014729 http://www.ebi.ac.uk/interpro/entry/IPR014729 InterPro IPR015864 http://www.ebi.ac.uk/interpro/entry/IPR015864 InterPro IPR015865 http://www.ebi.ac.uk/interpro/entry/IPR015865 InterPro IPR023465 http://www.ebi.ac.uk/interpro/entry/IPR023465 InterPro IPR023468 http://www.ebi.ac.uk/interpro/entry/IPR023468 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0023 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0023 KEGG_Gene eco:b0025 http://www.genome.jp/dbget-bin/www_bget?eco:b0025 KEGG_Orthology KO:K11753 http://www.genome.jp/dbget-bin/www_bget?KO:K11753 KEGG_Pathway ko00740 http://www.genome.jp/kegg-bin/show_pathway?ko00740 KEGG_Reaction rn:R00161 http://www.genome.jp/dbget-bin/www_bget?rn:R00161 KEGG_Reaction rn:R00549 http://www.genome.jp/dbget-bin/www_bget?rn:R00549 MINT MINT-1256514 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1256514 OMA FPTANMR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FPTANMR PANTHER PTHR22749 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22749 PSORT swissprot:RIBF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RIBF_ECOLI PSORT-B swissprot:RIBF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RIBF_ECOLI PSORT2 swissprot:RIBF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RIBF_ECOLI Pfam PF01687 http://pfam.xfam.org/family/PF01687 Pfam PF06574 http://pfam.xfam.org/family/PF06574 Phobius swissprot:RIBF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RIBF_ECOLI PhylomeDB P0AG40 http://phylomedb.org/?seqid=P0AG40 ProteinModelPortal P0AG40 http://www.proteinmodelportal.org/query/uniprot/P0AG40 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2985604 http://www.ncbi.nlm.nih.gov/pubmed/2985604 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414566 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414566 RefSeq WP_000767329 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000767329 SMART SM00904 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00904 SMR P0AG40 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AG40 STRING 511145.b0025 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0025&targetmode=cogs STRING COG0196 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0196&targetmode=cogs SUPFAM SSF82114 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF82114 TIGRFAMs TIGR00083 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00083 UniProtKB RIBF_ECOLI http://www.uniprot.org/uniprot/RIBF_ECOLI UniProtKB-AC P0AG40 http://www.uniprot.org/uniprot/P0AG40 charge swissprot:RIBF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RIBF_ECOLI eggNOG COG0196 http://eggnogapi.embl.de/nog_data/html/tree/COG0196 eggNOG ENOG4105DTN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DTN epestfind swissprot:RIBF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RIBF_ECOLI garnier swissprot:RIBF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RIBF_ECOLI helixturnhelix swissprot:RIBF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RIBF_ECOLI hmoment swissprot:RIBF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RIBF_ECOLI iep swissprot:RIBF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RIBF_ECOLI inforesidue swissprot:RIBF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RIBF_ECOLI octanol swissprot:RIBF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RIBF_ECOLI pepcoil swissprot:RIBF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RIBF_ECOLI pepdigest swissprot:RIBF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RIBF_ECOLI pepinfo swissprot:RIBF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RIBF_ECOLI pepnet swissprot:RIBF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RIBF_ECOLI pepstats swissprot:RIBF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RIBF_ECOLI pepwheel swissprot:RIBF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RIBF_ECOLI pepwindow swissprot:RIBF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RIBF_ECOLI sigcleave swissprot:RIBF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RIBF_ECOLI ## Database ID URL or Descriptions # AltName EF-P post-translational modification enzyme A {ECO:0000255|HAMAP-Rule MF_00174} # AltName EF-P-lysine lysyltransferase {ECO:0000255|HAMAP-Rule MF_00174} # AltName EPMA_ECOLI GX # BIOPHYSICOCHEMICAL PROPERTIES EPMA_ECOLI Kinetic parameters KM=213 uM for (R)-beta-lysine {ECO 0000269|PubMed 21841797}; KM=8600 uM for L-alpha-lysine {ECO 0000269|PubMed 21841797}; KM=6950 uM for (S)-beta-lysine {ECO 0000269|PubMed 21841797}; KM=206 uM for ATP {ECO 0000269|PubMed 21841797}; Note=kcat is 36 min(-1) for the amino acid activation reaction with (R)-beta-lysine as substrate.; # BioGrid 4260877 6 # CAUTION Was originally suggested to be a tRNA synthase, however its lack of an anticodon-binding domain made this highly unlikely. {ECO:0000305|PubMed 1761227}. # DISRUPTION PHENOTYPE EPMA_ECOLI Cells have a reduced pyruvate oxidase activity and a reduced growth rate. Cells lack CadA activity (lysine decarboxylase). {ECO 0000269|PubMed 20729861, ECO 0000269|PubMed 23239623, ECO 0000269|PubMed 6286595}. # EcoGene EG11211 epmA # FUNCTION EPMA_ECOLI With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P) on 'Lys-34'. Catalyzes the ATP-dependent activation of (R)- beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta-lysyl moiety is then transferred to the epsilon- amino group of EF-P 'Lys-34'. (R)-beta-lysine is 100-fold more efficient as a substrate than either (S)-beta-lysine or L-alpha- lysine. Cannot ligate lysine to any tRNA. {ECO 0000255|HAMAP- Rule MF_00174, ECO 0000269|PubMed 20729861, ECO 0000269|PubMed 21841797, ECO 0000269|PubMed 22128152}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004824 lysine-tRNA ligase activity; IEA:InterPro. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0016880 acid-ammonia (or amide) ligase activity; IEA:UniProtKB-HAMAP. # GO_function GO:0052868 protein-lysine lysyltransferase activity; IDA:EcoCyc. # GO_process GO:0006430 lysyl-tRNA aminoacylation; IEA:InterPro. # GO_process GO:0071915 protein-lysine lysylation; IDA:EcoCyc. # GO_process GO:0072581 protein-N6-(L-lysyl)-L-lysine modification to protein-N6-(beta-lysyl)-L-lysine; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0006464 cellular protein modification process # GOslim_process GO:0006520 cellular amino acid metabolic process # HAMAP MF_00174 EF_P_modif_A # IntAct P0A8N7 3 # InterPro IPR004364 aa-tRNA-synt_II # InterPro IPR004525 EpmA # InterPro IPR006195 aa-tRNA-synth_II # InterPro IPR018149 Lys-tRNA-synth_II_C # InterPro IPR018150 aa-tRNA-synt_II-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01007 Amino acid related enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # KEGG_Pathway ko00970 Aminoacyl-tRNA biosynthesis # Organism EPMA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR22594 PTHR22594 # PANTHER PTHR22594:SF7 PTHR22594:SF7 # PATRIC 32123883 VBIEscCol129921_4289 # PDB 3A5Y X-ray; 1.90 A; A/B/C/D=1-325 # PDB 3A5Z X-ray; 2.50 A; A/C/E/G=1-325 # PIR S56383 S56383 # PRINTS PR00982 TRNASYNTHLYS # PROSITE PS50862 AA_TRNA_LIGASE_II # Pfam PF00152 tRNA-synt_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Elongation factor P--(R)-beta-lysine ligase {ECO:0000255|HAMAP-Rule MF_00174} # RefSeq NP_418579 NC_000913.3 # RefSeq WP_000004771 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA97054.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the class-II aminoacyl-tRNA synthetase family. EpmA subfamily. {ECO:0000255|HAMAP-Rule MF_00174}. # SUBUNIT EPMA_ECOLI Homodimer. {ECO 0000255|HAMAP-Rule MF_00174, ECO 0000269|PubMed 20729861, ECO 0000269|PubMed 20823541}. # TIGRFAMs TIGR00462 genX # eggNOG COG2269 LUCA # eggNOG ENOG4105CAP Bacteria BLAST swissprot:EPMA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:EPMA_ECOLI BioCyc ECOL316407:JW4116-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4116-MONOMER BioCyc EcoCyc:EG11211-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11211-MONOMER BioCyc MetaCyc:EG11211-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11211-MONOMER COG COG2269 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2269 DIP DIP-10535N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10535N DOI 10.1016/0378-1119(91)90503-4 http://dx.doi.org/10.1016/0378-1119(91)90503-4 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nchembio.1001 http://dx.doi.org/10.1038/nchembio.1001 DOI 10.1038/nchembio.632 http://dx.doi.org/10.1038/nchembio.632 DOI 10.1038/nsmb.1889 http://dx.doi.org/10.1038/nsmb.1889 DOI 10.1073/pnas.86.16.6023 http://dx.doi.org/10.1073/pnas.86.16.6023 DOI 10.1074/jbc.M111.309633 http://dx.doi.org/10.1074/jbc.M111.309633 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1107/S1744309110032008 http://dx.doi.org/10.1107/S1744309110032008 DOI 10.1126/science.1228985 http://dx.doi.org/10.1126/science.1228985 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1186/1745-6150-5-3 http://dx.doi.org/10.1186/1745-6150-5-3 EC_number EC:6.3.1.- {ECO:0000255|HAMAP-Rule:MF_00174} http://www.genome.jp/dbget-bin/www_bget?EC:6.3.1.- {ECO:0000255|HAMAP-Rule:MF_00174} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01611 http://www.ebi.ac.uk/ena/data/view/J01611 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL X59988 http://www.ebi.ac.uk/ena/data/view/X59988 ENZYME 6.3.1.- {ECO:0000255|HAMAP-Rule:MF_00174} http://enzyme.expasy.org/EC/6.3.1.- {ECO:0000255|HAMAP-Rule:MF_00174} EchoBASE EB1196 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1196 EcoGene EG11211 http://www.ecogene.org/geneInfo.php?eg_id=EG11211 EnsemblBacteria AAC77115 http://www.ensemblgenomes.org/id/AAC77115 EnsemblBacteria AAC77115 http://www.ensemblgenomes.org/id/AAC77115 EnsemblBacteria BAE78159 http://www.ensemblgenomes.org/id/BAE78159 EnsemblBacteria BAE78159 http://www.ensemblgenomes.org/id/BAE78159 EnsemblBacteria BAE78159 http://www.ensemblgenomes.org/id/BAE78159 EnsemblBacteria b4155 http://www.ensemblgenomes.org/id/b4155 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004824 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004824 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016880 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016880 GO_function GO:0052868 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052868 GO_process GO:0006430 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006430 GO_process GO:0071915 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071915 GO_process GO:0072581 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0072581 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0006464 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006464 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GeneID 948672 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948672 HAMAP MF_00174 http://hamap.expasy.org/unirule/MF_00174 HOGENOM HOG000236579 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000236579&db=HOGENOM6 InParanoid P0A8N7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8N7 IntAct P0A8N7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8N7* IntEnz 6.3.1.- {ECO:0000255|HAMAP-Rule:MF_00174} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.1.- {ECO:0000255|HAMAP-Rule:MF_00174} InterPro IPR004364 http://www.ebi.ac.uk/interpro/entry/IPR004364 InterPro IPR004525 http://www.ebi.ac.uk/interpro/entry/IPR004525 InterPro IPR006195 http://www.ebi.ac.uk/interpro/entry/IPR006195 InterPro IPR018149 http://www.ebi.ac.uk/interpro/entry/IPR018149 InterPro IPR018150 http://www.ebi.ac.uk/interpro/entry/IPR018150 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW4116 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4116 KEGG_Gene eco:b4155 http://www.genome.jp/dbget-bin/www_bget?eco:b4155 KEGG_Orthology KO:K04568 http://www.genome.jp/dbget-bin/www_bget?KO:K04568 KEGG_Pathway ko00970 http://www.genome.jp/kegg-bin/show_pathway?ko00970 KEGG_Reaction rn:R03658 http://www.genome.jp/dbget-bin/www_bget?rn:R03658 OMA EEAGRHH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EEAGRHH PANTHER PTHR22594 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22594 PANTHER PTHR22594:SF7 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22594:SF7 PDB 3A5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3A5Y PDB 3A5Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3A5Z PDBsum 3A5Y http://www.ebi.ac.uk/pdbsum/3A5Y PDBsum 3A5Z http://www.ebi.ac.uk/pdbsum/3A5Z PRINTS PR00982 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00982 PROSITE PS50862 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50862 PSORT swissprot:EPMA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:EPMA_ECOLI PSORT-B swissprot:EPMA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:EPMA_ECOLI PSORT2 swissprot:EPMA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:EPMA_ECOLI Pfam PF00152 http://pfam.xfam.org/family/PF00152 Phobius swissprot:EPMA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:EPMA_ECOLI PhylomeDB P0A8N7 http://phylomedb.org/?seqid=P0A8N7 ProteinModelPortal P0A8N7 http://www.proteinmodelportal.org/query/uniprot/P0A8N7 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1761227 http://www.ncbi.nlm.nih.gov/pubmed/1761227 PubMed 20070887 http://www.ncbi.nlm.nih.gov/pubmed/20070887 PubMed 20729861 http://www.ncbi.nlm.nih.gov/pubmed/20729861 PubMed 20823541 http://www.ncbi.nlm.nih.gov/pubmed/20823541 PubMed 21841797 http://www.ncbi.nlm.nih.gov/pubmed/21841797 PubMed 22128152 http://www.ncbi.nlm.nih.gov/pubmed/22128152 PubMed 22706199 http://www.ncbi.nlm.nih.gov/pubmed/22706199 PubMed 23239623 http://www.ncbi.nlm.nih.gov/pubmed/23239623 PubMed 2668951 http://www.ncbi.nlm.nih.gov/pubmed/2668951 PubMed 6286595 http://www.ncbi.nlm.nih.gov/pubmed/6286595 PubMed 7037404 http://www.ncbi.nlm.nih.gov/pubmed/7037404 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418579 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418579 RefSeq WP_000004771 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000004771 SMR P0A8N7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8N7 STRING 511145.b4155 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4155&targetmode=cogs STRING COG2269 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2269&targetmode=cogs TIGRFAMs TIGR00462 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00462 UniProtKB EPMA_ECOLI http://www.uniprot.org/uniprot/EPMA_ECOLI UniProtKB-AC P0A8N7 http://www.uniprot.org/uniprot/P0A8N7 charge swissprot:EPMA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:EPMA_ECOLI eggNOG COG2269 http://eggnogapi.embl.de/nog_data/html/tree/COG2269 eggNOG ENOG4105CAP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CAP epestfind swissprot:EPMA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:EPMA_ECOLI garnier swissprot:EPMA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:EPMA_ECOLI helixturnhelix swissprot:EPMA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:EPMA_ECOLI hmoment swissprot:EPMA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:EPMA_ECOLI iep swissprot:EPMA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:EPMA_ECOLI inforesidue swissprot:EPMA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:EPMA_ECOLI octanol swissprot:EPMA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:EPMA_ECOLI pepcoil swissprot:EPMA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:EPMA_ECOLI pepdigest swissprot:EPMA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:EPMA_ECOLI pepinfo swissprot:EPMA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:EPMA_ECOLI pepnet swissprot:EPMA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:EPMA_ECOLI pepstats swissprot:EPMA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:EPMA_ECOLI pepwheel swissprot:EPMA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:EPMA_ECOLI pepwindow swissprot:EPMA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:EPMA_ECOLI sigcleave swissprot:EPMA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:EPMA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259606 249 # CATALYTIC ACTIVITY MURI_ECOLI L-glutamate = D-glutamate. {ECO 0000255|HAMAP- Rule MF_00258, ECO 0000269|PubMed 17568739, ECO 0000269|PubMed 8098327}. # ENZYME REGULATION The low basal catalytic activity in increased 1000-fold in the presence of UDP-MurNAc-Ala, the product of the preceding enzyme in the peptidoglycan biosynthesis. {ECO:0000269|PubMed 17568739}. # EcoGene EG11204 murI # FUNCTION MURI_ECOLI Provides the (R)-glutamate required for cell wall biosynthesis. {ECO 0000255|HAMAP-Rule MF_00258, ECO 0000269|PubMed 1355768, ECO 0000269|PubMed 8098327, ECO 0000305|PubMed 17568739}. # GO_function GO:0008881 glutamate racemase activity; IDA:EcoCyc. # GO_process GO:0008360 regulation of cell shape; IEA:UniProtKB-KW. # GO_process GO:0009252 peptidoglycan biosynthetic process; IMP:EcoCyc. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 3.40.50.1860 -; 1. # HAMAP MF_00258 Glu_racemase # IntAct P22634 13 # InterPro IPR001920 Asp/Glu_race # InterPro IPR004391 Glu_race # InterPro IPR015942 Asp/Glu/hydantoin_racemase # InterPro IPR018187 Asp/Glu_racemase_AS_1 # InterPro IPR033134 Asp/Glu_racemase_AS_2 # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00471 D-Glutamine and D-glutamate metabolism # Organism MURI_ECOLI Escherichia coli (strain K12) # PATHWAY MURI_ECOLI Cell wall biogenesis; peptidoglycan biosynthesis. {ECO 0000255|HAMAP-Rule MF_00258, ECO 0000269|PubMed 1355768, ECO 0000269|PubMed 8098327, ECO 0000305|PubMed 17568739}. # PATRIC 32123455 VBIEscCol129921_4088 # PDB 2JFN X-ray; 1.90 A; A=1-285 # PIR I41187 I41187 # PROSITE PS00923 ASP_GLU_RACEMASE_1 # PROSITE PS00924 ASP_GLU_RACEMASE_2 # Pfam PF01177 Asp_Glu_race # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MURI_ECOLI Glutamate racemase {ECO 0000255|HAMAP-Rule MF_00258, ECO 0000303|PubMed 8098327} # RefSeq NP_418402 NC_000913.3 # SEQUENCE CAUTION MURI_ECOLI Sequence=AAA23677.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=AAC43073.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=CAA23637.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; Sequence=CAA23638.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # SIMILARITY Belongs to the aspartate/glutamate racemases family. {ECO:0000255|HAMAP-Rule MF_00258}. # SUBUNIT Monomer. {ECO:0000269|PubMed 17568739}. # SUPFAM SSF53681 SSF53681; 2 # TIGRFAMs TIGR00067 glut_race # eggNOG COG0796 LUCA # eggNOG ENOG4105F03 Bacteria BLAST swissprot:MURI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MURI_ECOLI BioCyc ECOL316407:JW5550-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5550-MONOMER BioCyc EcoCyc:GLUTRACE-MONOMER http://biocyc.org/getid?id=EcoCyc:GLUTRACE-MONOMER BioCyc MetaCyc:GLUTRACE-MONOMER http://biocyc.org/getid?id=MetaCyc:GLUTRACE-MONOMER COG COG0796 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0796 DIP DIP-10283N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10283N DOI 10.1016/0022-2836(81)90508-8 http://dx.doi.org/10.1016/0022-2836(81)90508-8 DOI 10.1016/0167-4781(83)90027-1 http://dx.doi.org/10.1016/0167-4781(83)90027-1 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature05689 http://dx.doi.org/10.1038/nature05689 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.1.1.3 {ECO:0000255|HAMAP-Rule:MF_00258, ECO:0000269|PubMed:17568739, ECO:0000269|PubMed:8098327} http://www.genome.jp/dbget-bin/www_bget?EC:5.1.1.3 {ECO:0000255|HAMAP-Rule:MF_00258, ECO:0000269|PubMed:17568739, ECO:0000269|PubMed:8098327} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L14556 http://www.ebi.ac.uk/ena/data/view/L14556 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00347 http://www.ebi.ac.uk/ena/data/view/V00347 EMBL V00348 http://www.ebi.ac.uk/ena/data/view/V00348 ENZYME 5.1.1.3 {ECO:0000255|HAMAP-Rule:MF_00258, ECO:0000269|PubMed:17568739, ECO:0000269|PubMed:8098327} http://enzyme.expasy.org/EC/5.1.1.3 {ECO:0000255|HAMAP-Rule:MF_00258, ECO:0000269|PubMed:17568739, ECO:0000269|PubMed:8098327} EchoBASE EB1189 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1189 EcoGene EG11204 http://www.ecogene.org/geneInfo.php?eg_id=EG11204 EnsemblBacteria AAC76949 http://www.ensemblgenomes.org/id/AAC76949 EnsemblBacteria AAC76949 http://www.ensemblgenomes.org/id/AAC76949 EnsemblBacteria BAE77344 http://www.ensemblgenomes.org/id/BAE77344 EnsemblBacteria BAE77344 http://www.ensemblgenomes.org/id/BAE77344 EnsemblBacteria BAE77344 http://www.ensemblgenomes.org/id/BAE77344 EnsemblBacteria b3967 http://www.ensemblgenomes.org/id/b3967 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008881 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008881 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0009252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009252 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 3.40.50.1860 http://www.cathdb.info/version/latest/superfamily/3.40.50.1860 GeneID 948467 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948467 HAMAP MF_00258 http://hamap.expasy.org/unirule/MF_00258 HOGENOM HOG000262397 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000262397&db=HOGENOM6 InParanoid P22634 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P22634 IntAct P22634 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P22634* IntEnz 5.1.1.3 {ECO:0000255|HAMAP-Rule:MF_00258, ECO:0000269|PubMed:17568739, ECO:0000269|PubMed:8098327} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.1.1.3 {ECO:0000255|HAMAP-Rule:MF_00258, ECO:0000269|PubMed:17568739, ECO:0000269|PubMed:8098327} InterPro IPR001920 http://www.ebi.ac.uk/interpro/entry/IPR001920 InterPro IPR004391 http://www.ebi.ac.uk/interpro/entry/IPR004391 InterPro IPR015942 http://www.ebi.ac.uk/interpro/entry/IPR015942 InterPro IPR018187 http://www.ebi.ac.uk/interpro/entry/IPR018187 InterPro IPR033134 http://www.ebi.ac.uk/interpro/entry/IPR033134 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5550 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5550 KEGG_Gene eco:b3967 http://www.genome.jp/dbget-bin/www_bget?eco:b3967 KEGG_Orthology KO:K01776 http://www.genome.jp/dbget-bin/www_bget?KO:K01776 KEGG_Pathway ko00471 http://www.genome.jp/kegg-bin/show_pathway?ko00471 KEGG_Reaction rn:R00260 http://www.genome.jp/dbget-bin/www_bget?rn:R00260 MINT MINT-1222611 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1222611 OMA VPYGSKS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VPYGSKS PDB 2JFN http://www.ebi.ac.uk/pdbe-srv/view/entry/2JFN PDBsum 2JFN http://www.ebi.ac.uk/pdbsum/2JFN PROSITE PS00923 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00923 PROSITE PS00924 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00924 PSORT swissprot:MURI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MURI_ECOLI PSORT-B swissprot:MURI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MURI_ECOLI PSORT2 swissprot:MURI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MURI_ECOLI Pfam PF01177 http://pfam.xfam.org/family/PF01177 Phobius swissprot:MURI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MURI_ECOLI PhylomeDB P22634 http://phylomedb.org/?seqid=P22634 ProteinModelPortal P22634 http://www.proteinmodelportal.org/query/uniprot/P22634 PubMed 1355768 http://www.ncbi.nlm.nih.gov/pubmed/1355768 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17568739 http://www.ncbi.nlm.nih.gov/pubmed/17568739 PubMed 6297582 http://www.ncbi.nlm.nih.gov/pubmed/6297582 PubMed 7028991 http://www.ncbi.nlm.nih.gov/pubmed/7028991 PubMed 8093236 http://www.ncbi.nlm.nih.gov/pubmed/8093236 PubMed 8098327 http://www.ncbi.nlm.nih.gov/pubmed/8098327 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418402 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418402 SMR P22634 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P22634 STRING 511145.b3967 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3967&targetmode=cogs STRING COG0796 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0796&targetmode=cogs SUPFAM SSF53681 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53681 TIGRFAMs TIGR00067 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00067 UniProtKB MURI_ECOLI http://www.uniprot.org/uniprot/MURI_ECOLI UniProtKB-AC P22634 http://www.uniprot.org/uniprot/P22634 charge swissprot:MURI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MURI_ECOLI eggNOG COG0796 http://eggnogapi.embl.de/nog_data/html/tree/COG0796 eggNOG ENOG4105F03 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F03 epestfind swissprot:MURI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MURI_ECOLI garnier swissprot:MURI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MURI_ECOLI helixturnhelix swissprot:MURI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MURI_ECOLI hmoment swissprot:MURI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MURI_ECOLI iep swissprot:MURI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MURI_ECOLI inforesidue swissprot:MURI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MURI_ECOLI octanol swissprot:MURI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MURI_ECOLI pepcoil swissprot:MURI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MURI_ECOLI pepdigest swissprot:MURI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MURI_ECOLI pepinfo swissprot:MURI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MURI_ECOLI pepnet swissprot:MURI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MURI_ECOLI pepstats swissprot:MURI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MURI_ECOLI pepwheel swissprot:MURI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MURI_ECOLI pepwindow swissprot:MURI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MURI_ECOLI sigcleave swissprot:MURI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MURI_ECOLI ## Database ID URL or Descriptions # AltName ASTD_ECOLI Succinylglutamic semialdehyde dehydrogenase # BIOPHYSICOCHEMICAL PROPERTIES ASTD_ECOLI Kinetic parameters KM=91 uM for decanal {ECO 0000269|PubMed 15808744}; KM=160 uM for NAD (at pH 8.5) {ECO 0000269|PubMed 15808744}; KM=1.72 mM for succinic semialdehyde (at pH 8.5) {ECO 0000269|PubMed 15808744}; Vmax=5.0 umol/min/mg enzyme with decanal as substrate {ECO 0000269|PubMed 15808744}; Vmax=0.69 umol/min/mg enzyme with succinic semialdehyde as substrate {ECO 0000269|PubMed 15808744}; # BRENDA 1.2.1 2026 # BioGrid 4262236 13 # CATALYTIC ACTIVITY ASTD_ECOLI N-succinyl-L-glutamate 5-semialdehyde + NAD(+) + H(2)O = N-succinyl-L-glutamate + NADH. # CDD cd07095 ALDH_SGSD_AstD # EcoGene EG13997 astD # FUNCTION ASTD_ECOLI Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate. Also shows activity with decanal or succinic semialdehyde as the electron donor and NAD as the electron acceptor. No activity is detected with NADP as the electron acceptor. Therefore, is an aldehyde dehydrogenase with broad substrate specificity. {ECO 0000269|PubMed 15808744}. # GO_function GO:0004029 aldehyde dehydrogenase (NAD) activity; IDA:EcoCyc. # GO_function GO:0043824 succinylglutamate-semialdehyde dehydrogenase activity; IEA:UniProtKB-EC. # GO_process GO:0019544 arginine catabolic process to glutamate; IEA:UniProtKB-HAMAP. # GO_process GO:0019545 arginine catabolic process to succinate; IEA:UniProtKB-UniPathway. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # Gene3D 3.40.309.10 -; 1. # Gene3D 3.40.605.10 -; 1. # HAMAP MF_01174 Aldedh_AstD # INDUCTION ASTD_ECOLI By nitrogen starvation, and arginine. Induced at stationary phase by sigma S. {ECO 0000269|PubMed 12003934, ECO 0000269|PubMed 9696779}. # InterPro IPR015590 Aldehyde_DH_dom # InterPro IPR016160 Ald_DH_CS_CYS # InterPro IPR016161 Ald_DH/histidinol_DH # InterPro IPR016162 Ald_DH_N # InterPro IPR016163 Ald_DH_C # InterPro IPR017649 SuccinylGlu_semiald_DH_AstD # InterPro IPR029510 Ald_DH_CS_GLU # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00330 Arginine and proline metabolism # Organism ASTD_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5. {ECO 0000269|PubMed:9696779}. # PATRIC 32118801 VBIEscCol129921_1818 # PIR B64934 B64934 # PROSITE PS00070 ALDEHYDE_DEHYDR_CYS # PROSITE PS00687 ALDEHYDE_DEHYDR_GLU # Pfam PF00171 Aldedh # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ASTD_ECOLI N-succinylglutamate 5-semialdehyde dehydrogenase # RefSeq NP_416260 NC_000913.3 # RefSeq WP_000177206 NZ_LN832404.1 # SIMILARITY Belongs to the aldehyde dehydrogenase family. AstD subfamily. {ECO 0000305}. # SUPFAM SSF53720 SSF53720 # TIGRFAMs TIGR03240 arg_catab_astD # UniPathway UPA00185 UER00282 # eggNOG COG1012 LUCA # eggNOG ENOG4105C26 Bacteria BLAST swissprot:ASTD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ASTD_ECOLI BioCyc ECOL316407:JW5282-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5282-MONOMER BioCyc EcoCyc:SUCCGLUALDDEHYD-MONOMER http://biocyc.org/getid?id=EcoCyc:SUCCGLUALDDEHYD-MONOMER BioCyc MetaCyc:SUCCGLUALDDEHYD-MONOMER http://biocyc.org/getid?id=MetaCyc:SUCCGLUALDDEHYD-MONOMER COG COG1012 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1012 DIP DIP-9186N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9186N DOI 10.1016/j.fmrre.2004.12.006 http://dx.doi.org/10.1016/j.fmrre.2004.12.006 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.11.2940-2950.2002 http://dx.doi.org/10.1128/JB.184.11.2940-2950.2002 EC_number EC:1.2.1.71 http://www.genome.jp/dbget-bin/www_bget?EC:1.2.1.71 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.2.1.71 http://enzyme.expasy.org/EC/1.2.1.71 EchoBASE EB3753 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3753 EcoGene EG13997 http://www.ecogene.org/geneInfo.php?eg_id=EG13997 EnsemblBacteria AAC74816 http://www.ensemblgenomes.org/id/AAC74816 EnsemblBacteria AAC74816 http://www.ensemblgenomes.org/id/AAC74816 EnsemblBacteria BAA15538 http://www.ensemblgenomes.org/id/BAA15538 EnsemblBacteria BAA15538 http://www.ensemblgenomes.org/id/BAA15538 EnsemblBacteria BAA15538 http://www.ensemblgenomes.org/id/BAA15538 EnsemblBacteria b1746 http://www.ensemblgenomes.org/id/b1746 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004029 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004029 GO_function GO:0043824 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043824 GO_process GO:0019544 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019544 GO_process GO:0019545 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019545 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 3.40.309.10 http://www.cathdb.info/version/latest/superfamily/3.40.309.10 Gene3D 3.40.605.10 http://www.cathdb.info/version/latest/superfamily/3.40.605.10 GeneID 946260 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946260 HAMAP MF_01174 http://hamap.expasy.org/unirule/MF_01174 HOGENOM HOG000271506 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000271506&db=HOGENOM6 InParanoid P76217 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76217 IntAct P76217 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76217* IntEnz 1.2.1.71 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.2.1.71 InterPro IPR015590 http://www.ebi.ac.uk/interpro/entry/IPR015590 InterPro IPR016160 http://www.ebi.ac.uk/interpro/entry/IPR016160 InterPro IPR016161 http://www.ebi.ac.uk/interpro/entry/IPR016161 InterPro IPR016162 http://www.ebi.ac.uk/interpro/entry/IPR016162 InterPro IPR016163 http://www.ebi.ac.uk/interpro/entry/IPR016163 InterPro IPR017649 http://www.ebi.ac.uk/interpro/entry/IPR017649 InterPro IPR029510 http://www.ebi.ac.uk/interpro/entry/IPR029510 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5282 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5282 KEGG_Gene eco:b1746 http://www.genome.jp/dbget-bin/www_bget?eco:b1746 KEGG_Orthology KO:K06447 http://www.genome.jp/dbget-bin/www_bget?KO:K06447 KEGG_Pathway ko00330 http://www.genome.jp/kegg-bin/show_pathway?ko00330 KEGG_Reaction rn:R05049 http://www.genome.jp/dbget-bin/www_bget?rn:R05049 OMA WQGNDAG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WQGNDAG PROSITE PS00070 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00070 PROSITE PS00687 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00687 PSORT swissprot:ASTD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ASTD_ECOLI PSORT-B swissprot:ASTD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ASTD_ECOLI PSORT2 swissprot:ASTD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ASTD_ECOLI Pfam PF00171 http://pfam.xfam.org/family/PF00171 Phobius swissprot:ASTD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ASTD_ECOLI PhylomeDB P76217 http://phylomedb.org/?seqid=P76217 ProteinModelPortal P76217 http://www.proteinmodelportal.org/query/uniprot/P76217 PubMed 12003934 http://www.ncbi.nlm.nih.gov/pubmed/12003934 PubMed 15808744 http://www.ncbi.nlm.nih.gov/pubmed/15808744 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9696779 http://www.ncbi.nlm.nih.gov/pubmed/9696779 RefSeq NP_416260 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416260 RefSeq WP_000177206 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000177206 SMR P76217 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76217 STRING 511145.b1746 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1746&targetmode=cogs STRING COG1012 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1012&targetmode=cogs SUPFAM SSF53720 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53720 TIGRFAMs TIGR03240 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03240 UniProtKB ASTD_ECOLI http://www.uniprot.org/uniprot/ASTD_ECOLI UniProtKB-AC P76217 http://www.uniprot.org/uniprot/P76217 charge swissprot:ASTD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ASTD_ECOLI eggNOG COG1012 http://eggnogapi.embl.de/nog_data/html/tree/COG1012 eggNOG ENOG4105C26 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C26 epestfind swissprot:ASTD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ASTD_ECOLI garnier swissprot:ASTD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ASTD_ECOLI helixturnhelix swissprot:ASTD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ASTD_ECOLI hmoment swissprot:ASTD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ASTD_ECOLI iep swissprot:ASTD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ASTD_ECOLI inforesidue swissprot:ASTD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ASTD_ECOLI octanol swissprot:ASTD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ASTD_ECOLI pepcoil swissprot:ASTD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ASTD_ECOLI pepdigest swissprot:ASTD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ASTD_ECOLI pepinfo swissprot:ASTD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ASTD_ECOLI pepnet swissprot:ASTD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ASTD_ECOLI pepstats swissprot:ASTD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ASTD_ECOLI pepwheel swissprot:ASTD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ASTD_ECOLI pepwindow swissprot:ASTD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ASTD_ECOLI sigcleave swissprot:ASTD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ASTD_ECOLI ## Database ID URL or Descriptions # BioGrid 4260183 9 # EcoGene EG13752 ydcI # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0000986 bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding; IBA:GO_Central. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_function GO:0043565 sequence-specific DNA binding; IDA:EcoCyc. # GO_process GO:0006351 transcription, DNA-templated; ISS:EcoCyc. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # InterPro IPR000847 Tscrpt_reg_HTH_LysR # InterPro IPR005119 LysR_subst-bd # InterPro IPR011991 WHTH_DNA-bd_dom # Organism YDCI_ECOLI Escherichia coli (strain K12) # PATRIC 32118130 VBIEscCol129921_1485 # PIR A64894 A64894 # PRINTS PR00039 HTHLYSR # PROSITE PS50931 HTH_LYSR # Pfam PF00126 HTH_1 # Pfam PF03466 LysR_substrate # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDCI_ECOLI Uncharacterized HTH-type transcriptional regulator YdcI # RefSeq NP_415939 NC_000913.3 # RefSeq WP_000414567 NZ_LN832404.1 # SIMILARITY Contains 1 HTH lysR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00253}. # SUPFAM SSF46785 SSF46785 # eggNOG ENOG4105DDW Bacteria # eggNOG ENOG410YQ2R LUCA BLAST swissprot:YDCI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDCI_ECOLI BioCyc ECOL316407:JW5226-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5226-MONOMER BioCyc EcoCyc:G6737-MONOMER http://biocyc.org/getid?id=EcoCyc:G6737-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3515 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3515 EcoGene EG13752 http://www.ecogene.org/geneInfo.php?eg_id=EG13752 EnsemblBacteria AAC74504 http://www.ensemblgenomes.org/id/AAC74504 EnsemblBacteria AAC74504 http://www.ensemblgenomes.org/id/AAC74504 EnsemblBacteria BAA15045 http://www.ensemblgenomes.org/id/BAA15045 EnsemblBacteria BAA15045 http://www.ensemblgenomes.org/id/BAA15045 EnsemblBacteria BAA15045 http://www.ensemblgenomes.org/id/BAA15045 EnsemblBacteria b1422 http://www.ensemblgenomes.org/id/b1422 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000986 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000986 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 948865 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948865 HOGENOM HOG000233516 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000233516&db=HOGENOM6 InParanoid P77171 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77171 InterPro IPR000847 http://www.ebi.ac.uk/interpro/entry/IPR000847 InterPro IPR005119 http://www.ebi.ac.uk/interpro/entry/IPR005119 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW5226 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5226 KEGG_Gene eco:b1422 http://www.genome.jp/dbget-bin/www_bget?eco:b1422 OMA LCFLEIA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LCFLEIA PRINTS PR00039 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00039 PROSITE PS50931 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50931 PSORT swissprot:YDCI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDCI_ECOLI PSORT-B swissprot:YDCI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDCI_ECOLI PSORT2 swissprot:YDCI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDCI_ECOLI Pfam PF00126 http://pfam.xfam.org/family/PF00126 Pfam PF03466 http://pfam.xfam.org/family/PF03466 Phobius swissprot:YDCI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDCI_ECOLI PhylomeDB P77171 http://phylomedb.org/?seqid=P77171 ProteinModelPortal P77171 http://www.proteinmodelportal.org/query/uniprot/P77171 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415939 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415939 RefSeq WP_000414567 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000414567 SMR P77171 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77171 STRING 511145.b1422 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1422&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB YDCI_ECOLI http://www.uniprot.org/uniprot/YDCI_ECOLI UniProtKB-AC P77171 http://www.uniprot.org/uniprot/P77171 charge swissprot:YDCI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDCI_ECOLI eggNOG ENOG4105DDW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DDW eggNOG ENOG410YQ2R http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YQ2R epestfind swissprot:YDCI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDCI_ECOLI garnier swissprot:YDCI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDCI_ECOLI helixturnhelix swissprot:YDCI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDCI_ECOLI hmoment swissprot:YDCI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDCI_ECOLI iep swissprot:YDCI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDCI_ECOLI inforesidue swissprot:YDCI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDCI_ECOLI octanol swissprot:YDCI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDCI_ECOLI pepcoil swissprot:YDCI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDCI_ECOLI pepdigest swissprot:YDCI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDCI_ECOLI pepinfo swissprot:YDCI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDCI_ECOLI pepnet swissprot:YDCI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDCI_ECOLI pepstats swissprot:YDCI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDCI_ECOLI pepwheel swissprot:YDCI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDCI_ECOLI pepwindow swissprot:YDCI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDCI_ECOLI sigcleave swissprot:YDCI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDCI_ECOLI ## Database ID URL or Descriptions # BioGrid 4263135 10 # EcoGene EG13686 ybjQ # Gene3D 3.30.110.70 -; 1. # HAMAP MF_00338 UPF0145 # InterPro IPR002765 UPF0145 # Organism YBJQ_ECOLI Escherichia coli (strain K12) # PATRIC 32116939 VBIEscCol129921_0895 # PIR B64825 B64825 # Pfam PF01906 YbjQ_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBJQ_ECOLI UPF0145 protein YbjQ # RefSeq NP_415387 NC_000913.3 # RefSeq WP_001160737 NZ_LN832404.1 # SIMILARITY Belongs to the UPF0145 family. {ECO 0000305}. # SUPFAM SSF117782 SSF117782 # eggNOG COG0393 LUCA # eggNOG ENOG4105K8R Bacteria BLAST swissprot:YBJQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBJQ_ECOLI BioCyc ECOL316407:JW0850-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0850-MONOMER BioCyc EcoCyc:G6451-MONOMER http://biocyc.org/getid?id=EcoCyc:G6451-MONOMER DIP DIP-48266N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48266N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3450 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3450 EcoGene EG13686 http://www.ecogene.org/geneInfo.php?eg_id=EG13686 EnsemblBacteria AAC73953 http://www.ensemblgenomes.org/id/AAC73953 EnsemblBacteria AAC73953 http://www.ensemblgenomes.org/id/AAC73953 EnsemblBacteria BAA35580 http://www.ensemblgenomes.org/id/BAA35580 EnsemblBacteria BAA35580 http://www.ensemblgenomes.org/id/BAA35580 EnsemblBacteria BAA35580 http://www.ensemblgenomes.org/id/BAA35580 EnsemblBacteria b0866 http://www.ensemblgenomes.org/id/b0866 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 3.30.110.70 http://www.cathdb.info/version/latest/superfamily/3.30.110.70 GeneID 945493 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945493 HAMAP MF_00338 http://hamap.expasy.org/unirule/MF_00338 HOGENOM HOG000217614 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000217614&db=HOGENOM6 InParanoid P0A8C1 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8C1 IntAct P0A8C1 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8C1* InterPro IPR002765 http://www.ebi.ac.uk/interpro/entry/IPR002765 KEGG_Gene ecj:JW0850 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0850 KEGG_Gene eco:b0866 http://www.genome.jp/dbget-bin/www_bget?eco:b0866 OMA IREYRGI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IREYRGI PSORT swissprot:YBJQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBJQ_ECOLI PSORT-B swissprot:YBJQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBJQ_ECOLI PSORT2 swissprot:YBJQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBJQ_ECOLI Pfam PF01906 http://pfam.xfam.org/family/PF01906 Phobius swissprot:YBJQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBJQ_ECOLI PhylomeDB P0A8C1 http://phylomedb.org/?seqid=P0A8C1 ProteinModelPortal P0A8C1 http://www.proteinmodelportal.org/query/uniprot/P0A8C1 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415387 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415387 RefSeq WP_001160737 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001160737 SMR P0A8C1 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8C1 STRING 511145.b0866 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0866&targetmode=cogs SUPFAM SSF117782 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF117782 UniProtKB YBJQ_ECOLI http://www.uniprot.org/uniprot/YBJQ_ECOLI UniProtKB-AC P0A8C1 http://www.uniprot.org/uniprot/P0A8C1 charge swissprot:YBJQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBJQ_ECOLI eggNOG COG0393 http://eggnogapi.embl.de/nog_data/html/tree/COG0393 eggNOG ENOG4105K8R http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105K8R epestfind swissprot:YBJQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBJQ_ECOLI garnier swissprot:YBJQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBJQ_ECOLI helixturnhelix swissprot:YBJQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBJQ_ECOLI hmoment swissprot:YBJQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBJQ_ECOLI iep swissprot:YBJQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBJQ_ECOLI inforesidue swissprot:YBJQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBJQ_ECOLI octanol swissprot:YBJQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBJQ_ECOLI pepcoil swissprot:YBJQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBJQ_ECOLI pepdigest swissprot:YBJQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBJQ_ECOLI pepinfo swissprot:YBJQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBJQ_ECOLI pepnet swissprot:YBJQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBJQ_ECOLI pepstats swissprot:YBJQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBJQ_ECOLI pepwheel swissprot:YBJQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBJQ_ECOLI pepwindow swissprot:YBJQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBJQ_ECOLI sigcleave swissprot:YBJQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBJQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4259838 195 # CDD cd06174 MFS # EcoGene EG12183 ampG # FUNCTION AMPG_ECOLI Probably acts as a permease in the beta-lactamase induction system and in peptidoglycan recycling. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_process GO:0055085 transmembrane transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0055085 transmembrane transport # InterPro IPR004752 AmpG_permease/AT-1 # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # KEGG_Brite ko02000 Transporters # Organism AMPG_ECOLI Escherichia coli (strain K12) # PATRIC 32116017 VBIEscCol129921_0450 # PIR S37391 S37391 # PROSITE PS50850 MFS # Pfam PF07690 MFS_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AMPG_ECOLI Protein AmpG # RefSeq NP_414967 NC_000913.3 # RefSeq WP_000098429 NZ_LN832404.1 # SIMILARITY Belongs to the major facilitator superfamily. {ECO 0000305}. # SUBCELLULAR LOCATION AMPG_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.25 the major facilitator superfamily (mfs) # TIGRFAMs TIGR00901 2A0125 # eggNOG COG0477 LUCA # eggNOG ENOG4105EYM Bacteria BLAST swissprot:AMPG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AMPG_ECOLI BioCyc ECOL316407:JW0423-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0423-MONOMER BioCyc EcoCyc:AMPG-MONOMER http://biocyc.org/getid?id=EcoCyc:AMPG-MONOMER BioCyc MetaCyc:AMPG-MONOMER http://biocyc.org/getid?id=MetaCyc:AMPG-MONOMER COG COG0477 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0477 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1099/13500872-141-5-1085 http://dx.doi.org/10.1099/13500872-141-5-1085 DOI 10.1111/j.1365-2958.1993.tb01731.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb01731.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL S67816 http://www.ebi.ac.uk/ena/data/view/S67816 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL X82158 http://www.ebi.ac.uk/ena/data/view/X82158 EMBL X82159 http://www.ebi.ac.uk/ena/data/view/X82159 EMBL X82160 http://www.ebi.ac.uk/ena/data/view/X82160 EchoBASE EB2100 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2100 EcoGene EG12183 http://www.ecogene.org/geneInfo.php?eg_id=EG12183 EnsemblBacteria AAC73536 http://www.ensemblgenomes.org/id/AAC73536 EnsemblBacteria AAC73536 http://www.ensemblgenomes.org/id/AAC73536 EnsemblBacteria BAE76213 http://www.ensemblgenomes.org/id/BAE76213 EnsemblBacteria BAE76213 http://www.ensemblgenomes.org/id/BAE76213 EnsemblBacteria BAE76213 http://www.ensemblgenomes.org/id/BAE76213 EnsemblBacteria b0433 http://www.ensemblgenomes.org/id/b0433 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 946438 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946438 HOGENOM HOG000217208 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000217208&db=HOGENOM6 InParanoid P0AE16 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AE16 InterPro IPR004752 http://www.ebi.ac.uk/interpro/entry/IPR004752 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0423 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0423 KEGG_Gene eco:b0433 http://www.genome.jp/dbget-bin/www_bget?eco:b0433 KEGG_Orthology KO:K08218 http://www.genome.jp/dbget-bin/www_bget?KO:K08218 OMA GYFSWIA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GYFSWIA PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:AMPG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AMPG_ECOLI PSORT-B swissprot:AMPG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AMPG_ECOLI PSORT2 swissprot:AMPG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AMPG_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:AMPG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AMPG_ECOLI PhylomeDB P0AE16 http://phylomedb.org/?seqid=P0AE16 ProteinModelPortal P0AE16 http://www.proteinmodelportal.org/query/uniprot/P0AE16 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7773404 http://www.ncbi.nlm.nih.gov/pubmed/7773404 PubMed 8231804 http://www.ncbi.nlm.nih.gov/pubmed/8231804 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414967 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414967 RefSeq WP_000098429 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000098429 STRING 511145.b0433 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0433&targetmode=cogs STRING COG0477 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0477&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.25 http://www.tcdb.org/search/result.php?tc=2.A.1.25 TIGRFAMs TIGR00901 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00901 UniProtKB AMPG_ECOLI http://www.uniprot.org/uniprot/AMPG_ECOLI UniProtKB-AC P0AE16 http://www.uniprot.org/uniprot/P0AE16 charge swissprot:AMPG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AMPG_ECOLI eggNOG COG0477 http://eggnogapi.embl.de/nog_data/html/tree/COG0477 eggNOG ENOG4105EYM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EYM epestfind swissprot:AMPG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AMPG_ECOLI garnier swissprot:AMPG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AMPG_ECOLI helixturnhelix swissprot:AMPG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AMPG_ECOLI hmoment swissprot:AMPG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AMPG_ECOLI iep swissprot:AMPG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AMPG_ECOLI inforesidue swissprot:AMPG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AMPG_ECOLI octanol swissprot:AMPG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AMPG_ECOLI pepcoil swissprot:AMPG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AMPG_ECOLI pepdigest swissprot:AMPG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AMPG_ECOLI pepinfo swissprot:AMPG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AMPG_ECOLI pepnet swissprot:AMPG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AMPG_ECOLI pepstats swissprot:AMPG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AMPG_ECOLI pepwheel swissprot:AMPG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AMPG_ECOLI pepwindow swissprot:AMPG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AMPG_ECOLI sigcleave swissprot:AMPG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AMPG_ECOLI ## Database ID URL or Descriptions # BioGrid 4261183 17 # EcoGene EG13003 yghS # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.300 -; 1. # InterPro IPR027417 P-loop_NTPase # Organism YGHS_ECOLI Escherichia coli (strain K12) # PATRIC 32121386 VBIEscCol129921_3080 # PIR G65084 G65084 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGHS_ECOLI Uncharacterized ATP-binding protein YghS # RefSeq NP_417459 NC_000913.3 # SIMILARITY To E.coli YghR and YghT. {ECO 0000305}. # SUPFAM SSF52540 SSF52540 # eggNOG ENOG4108NDC Bacteria # eggNOG ENOG410Y3HG LUCA BLAST swissprot:YGHS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGHS_ECOLI BioCyc ECOL316407:JW5491-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5491-MONOMER BioCyc EcoCyc:G7551-MONOMER http://biocyc.org/getid?id=EcoCyc:G7551-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EchoBASE EB2825 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2825 EcoGene EG13003 http://www.ecogene.org/geneInfo.php?eg_id=EG13003 EnsemblBacteria AAC76021 http://www.ensemblgenomes.org/id/AAC76021 EnsemblBacteria AAC76021 http://www.ensemblgenomes.org/id/AAC76021 EnsemblBacteria BAE77046 http://www.ensemblgenomes.org/id/BAE77046 EnsemblBacteria BAE77046 http://www.ensemblgenomes.org/id/BAE77046 EnsemblBacteria BAE77046 http://www.ensemblgenomes.org/id/BAE77046 EnsemblBacteria b2985 http://www.ensemblgenomes.org/id/b2985 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 947476 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947476 HOGENOM HOG000124979 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000124979&db=HOGENOM6 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Gene ecj:JW5491 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5491 KEGG_Gene eco:b2985 http://www.genome.jp/dbget-bin/www_bget?eco:b2985 OMA ATMPTEH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ATMPTEH PSORT swissprot:YGHS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGHS_ECOLI PSORT-B swissprot:YGHS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGHS_ECOLI PSORT2 swissprot:YGHS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGHS_ECOLI Phobius swissprot:YGHS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGHS_ECOLI PhylomeDB Q46843 http://phylomedb.org/?seqid=Q46843 ProteinModelPortal Q46843 http://www.proteinmodelportal.org/query/uniprot/Q46843 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417459 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417459 STRING 511145.b2985 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2985&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB YGHS_ECOLI http://www.uniprot.org/uniprot/YGHS_ECOLI UniProtKB-AC Q46843 http://www.uniprot.org/uniprot/Q46843 charge swissprot:YGHS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGHS_ECOLI eggNOG ENOG4108NDC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108NDC eggNOG ENOG410Y3HG http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y3HG epestfind swissprot:YGHS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGHS_ECOLI garnier swissprot:YGHS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGHS_ECOLI helixturnhelix swissprot:YGHS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGHS_ECOLI hmoment swissprot:YGHS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGHS_ECOLI iep swissprot:YGHS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGHS_ECOLI inforesidue swissprot:YGHS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGHS_ECOLI octanol swissprot:YGHS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGHS_ECOLI pepcoil swissprot:YGHS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGHS_ECOLI pepdigest swissprot:YGHS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGHS_ECOLI pepinfo swissprot:YGHS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGHS_ECOLI pepnet swissprot:YGHS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGHS_ECOLI pepstats swissprot:YGHS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGHS_ECOLI pepwheel swissprot:YGHS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGHS_ECOLI pepwindow swissprot:YGHS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGHS_ECOLI sigcleave swissprot:YGHS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGHS_ECOLI ## Database ID URL or Descriptions # AltName PABB_ECOLI 4-amino-4-deoxychorismate synthase component 1 # BIOPHYSICOCHEMICAL PROPERTIES PABB_ECOLI Kinetic parameters KM=4.2 uM for chorismate (with PabA and glutamine as the amino donor at pH 7.5) {ECO 0000269|PubMed 14982443, ECO 0000269|PubMed 16605270, ECO 0000269|PubMed 7592344}; KM=18.6 uM for chorismate (with PabA and ammonia as the amino donor at pH 7.5) {ECO 0000269|PubMed 14982443, ECO 0000269|PubMed 16605270, ECO 0000269|PubMed 7592344}; KM=71 uM for chorismate {ECO 0000269|PubMed 14982443, ECO 0000269|PubMed 16605270, ECO 0000269|PubMed 7592344}; KM=75 uM for chorismate (with PabA) {ECO 0000269|PubMed 14982443, ECO 0000269|PubMed 16605270, ECO 0000269|PubMed 7592344}; KM=379 uM for chorismate (with PabA and ammonia) {ECO 0000269|PubMed 14982443, ECO 0000269|PubMed 16605270, ECO 0000269|PubMed 7592344}; KM=388 uM for chorismate (with ammonia) {ECO 0000269|PubMed 14982443, ECO 0000269|PubMed 16605270, ECO 0000269|PubMed 7592344}; # BRENDA 2.6.1.85 2026 # BioGrid 4260345 170 # CATALYTIC ACTIVITY PABB_ECOLI Chorismate + L-glutamine = 4-amino-4- deoxychorismate + L-glutamate. {ECO 0000269|PubMed 16605270, ECO 0000269|PubMed 2251281}. # COFACTOR PABB_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 2251281}; # DISRUPTION PHENOTYPE Cells lacking this gene do not produce 4- aminobenzoate. {ECO:0000269|PubMed 4914080}. # ENZYME REGULATION PABB_ECOLI Inhibited by 6-diazo-5-oxo-L-norleucine (DON). The inhibition is competitive with glutamine but uncompetitive with chorismate. Also inhibited by 2-fluorochorismate. {ECO 0000269|PubMed 15303852, ECO 0000269|PubMed 7592344}. # EcoGene EG10683 pabB # FUNCTION PABB_ECOLI Part of a heterodimeric complex that catalyzes the two- step biosynthesis of 4-amino-4-deoxychorismate (ADC), a precursor of p-aminobenzoate (PABA) and tetrahydrofolate. In the first step, a glutamine amidotransferase (PabA) generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by aminodeoxychorismate synthase (PabB) to produce ADC. PabB, in the absence of PabA, can catalyze the formation of ADC in the presence of exogenous ammonia. {ECO 0000269|PubMed 16605270, ECO 0000269|PubMed 2251281, ECO 0000269|PubMed 4914080}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0000287 magnesium ion binding; IDA:UniProtKB. # GO_function GO:0016833 oxo-acid-lyase activity; IEA:InterPro. # GO_function GO:0046820 4-amino-4-deoxychorismate synthase activity; IDA:UniProtKB. # GO_process GO:0046654 tetrahydrofolate biosynthetic process; IDA:UniProtKB. # GO_process GO:0046656 folic acid biosynthetic process; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.60.120.10 -; 1. # IntAct P05041 6 # InterPro IPR005801 ADC_synthase # InterPro IPR005802 Para-NH2Bz_synth_comp_1 # InterPro IPR006805 Anth_synth_I_N # InterPro IPR015890 Chorismate_C # InterPro IPR019999 Anth_synth_I-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00790 Folate biosynthesis # MISCELLANEOUS PABB_ECOLI In this enzymatic reaction the C4 hydroxy group of chorismate is replaced by addition of a nucleophile at the C2 position. The nucleophile is the epsilon-amino group of lysine 274 transiently binds to C2 of chorismate (PubMed 16605270). PabB contains a tryptophan (Trp) molecule deeply embedded in a binding pocket. Trp which cannot be dissociated without denaturation of PabB, may play a structural role in the enzyme since it has no effect on the enzymic synthesis of aminodeoxychorismate (PubMed 11841211). {ECO 0000305|PubMed 11841211, ECO 0000305|PubMed 16605270}. # Organism PABB_ECOLI Escherichia coli (strain K12) # PATHWAY Cofactor biosynthesis; tetrahydrofolate biosynthesis; 4- aminobenzoate from chorismate step 1/2. # PATRIC 32118943 VBIEscCol129921_1889 # PDB 1K0E X-ray; 2.00 A; A/B=1-453 # PDB 1K0G X-ray; 2.05 A; A/B=1-453 # PIR A30251 AGEC1 # PRINTS PR00095 ANTSNTHASEI # Pfam PF00425 Chorismate_bind # Pfam PF04715 Anth_synt_I_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PABB_ECOLI Aminodeoxychorismate synthase component 1 # RefSeq NP_416326 NC_000913.3 # SIMILARITY Belongs to the anthranilate synthase component I family. {ECO 0000305}. # SUBUNIT PABB_ECOLI Monomer. Heterodimer consisting of two non-identical subunits a glutamine amidotransferase subunit (PabA) and a aminodeoxychorismate synthase subunit (PabB). {ECO 0000269|PubMed 11841211, ECO 0000269|PubMed 8679677}. # SUPFAM SSF56322 SSF56322 # TIGRFAMs TIGR00553 pabB # UniPathway UPA00077 UER00149 # eggNOG COG0147 LUCA # eggNOG ENOG4105CRQ Bacteria BLAST swissprot:PABB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PABB_ECOLI BioCyc ECOL316407:JW1801-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1801-MONOMER BioCyc EcoCyc:PABASYN-COMPI-MONOMER http://biocyc.org/getid?id=EcoCyc:PABASYN-COMPI-MONOMER BioCyc MetaCyc:PABASYN-COMPI-MONOMER http://biocyc.org/getid?id=MetaCyc:PABASYN-COMPI-MONOMER COG COG0147 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0147 DIP DIP-10434N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10434N DOI 10.1016/0167-4838(96)00029-5 http://dx.doi.org/10.1016/0167-4838(96)00029-5 DOI 10.1021/bi015791b http://dx.doi.org/10.1021/bi015791b DOI 10.1021/bi052216p http://dx.doi.org/10.1021/bi052216p DOI 10.1021/ja0389927 http://dx.doi.org/10.1021/ja0389927 DOI 10.1021/ja048312f http://dx.doi.org/10.1021/ja048312f DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.87.23.9391 http://dx.doi.org/10.1073/pnas.87.23.9391 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.6.1.85 http://www.genome.jp/dbget-bin/www_bget?EC:2.6.1.85 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K02673 http://www.ebi.ac.uk/ena/data/view/K02673 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U07748 http://www.ebi.ac.uk/ena/data/view/U07748 EMBL U07749 http://www.ebi.ac.uk/ena/data/view/U07749 EMBL U07762 http://www.ebi.ac.uk/ena/data/view/U07762 ENZYME 2.6.1.85 http://enzyme.expasy.org/EC/2.6.1.85 EchoBASE EB0677 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0677 EcoGene EG10683 http://www.ecogene.org/geneInfo.php?eg_id=EG10683 EnsemblBacteria AAC74882 http://www.ensemblgenomes.org/id/AAC74882 EnsemblBacteria AAC74882 http://www.ensemblgenomes.org/id/AAC74882 EnsemblBacteria BAA15619 http://www.ensemblgenomes.org/id/BAA15619 EnsemblBacteria BAA15619 http://www.ensemblgenomes.org/id/BAA15619 EnsemblBacteria BAA15619 http://www.ensemblgenomes.org/id/BAA15619 EnsemblBacteria b1812 http://www.ensemblgenomes.org/id/b1812 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0016833 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016833 GO_function GO:0046820 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046820 GO_process GO:0046654 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046654 GO_process GO:0046656 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046656 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.60.120.10 http://www.cathdb.info/version/latest/superfamily/3.60.120.10 GeneID 946337 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946337 HOGENOM HOG000025142 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000025142&db=HOGENOM6 InParanoid P05041 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P05041 IntAct P05041 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P05041* IntEnz 2.6.1.85 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.6.1.85 InterPro IPR005801 http://www.ebi.ac.uk/interpro/entry/IPR005801 InterPro IPR005802 http://www.ebi.ac.uk/interpro/entry/IPR005802 InterPro IPR006805 http://www.ebi.ac.uk/interpro/entry/IPR006805 InterPro IPR015890 http://www.ebi.ac.uk/interpro/entry/IPR015890 InterPro IPR019999 http://www.ebi.ac.uk/interpro/entry/IPR019999 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1801 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1801 KEGG_Gene eco:b1812 http://www.genome.jp/dbget-bin/www_bget?eco:b1812 KEGG_Orthology KO:K01665 http://www.genome.jp/dbget-bin/www_bget?KO:K01665 KEGG_Pathway ko00790 http://www.genome.jp/kegg-bin/show_pathway?ko00790 KEGG_Reaction rn:R01716 http://www.genome.jp/dbget-bin/www_bget?rn:R01716 OMA SHQPWAM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SHQPWAM PDB 1K0E http://www.ebi.ac.uk/pdbe-srv/view/entry/1K0E PDB 1K0G http://www.ebi.ac.uk/pdbe-srv/view/entry/1K0G PDBsum 1K0E http://www.ebi.ac.uk/pdbsum/1K0E PDBsum 1K0G http://www.ebi.ac.uk/pdbsum/1K0G PRINTS PR00095 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00095 PSORT swissprot:PABB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PABB_ECOLI PSORT-B swissprot:PABB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PABB_ECOLI PSORT2 swissprot:PABB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PABB_ECOLI Pfam PF00425 http://pfam.xfam.org/family/PF00425 Pfam PF04715 http://pfam.xfam.org/family/PF04715 Phobius swissprot:PABB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PABB_ECOLI PhylomeDB P05041 http://phylomedb.org/?seqid=P05041 ProteinModelPortal P05041 http://www.proteinmodelportal.org/query/uniprot/P05041 PubMed 11841211 http://www.ncbi.nlm.nih.gov/pubmed/11841211 PubMed 14982443 http://www.ncbi.nlm.nih.gov/pubmed/14982443 PubMed 15303852 http://www.ncbi.nlm.nih.gov/pubmed/15303852 PubMed 16605270 http://www.ncbi.nlm.nih.gov/pubmed/16605270 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2251281 http://www.ncbi.nlm.nih.gov/pubmed/2251281 PubMed 4914080 http://www.ncbi.nlm.nih.gov/pubmed/4914080 PubMed 6330050 http://www.ncbi.nlm.nih.gov/pubmed/6330050 PubMed 7592344 http://www.ncbi.nlm.nih.gov/pubmed/7592344 PubMed 7896119 http://www.ncbi.nlm.nih.gov/pubmed/7896119 PubMed 8679677 http://www.ncbi.nlm.nih.gov/pubmed/8679677 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416326 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416326 SMR P05041 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P05041 STRING 511145.b1812 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1812&targetmode=cogs STRING COG0147 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0147&targetmode=cogs SUPFAM SSF56322 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56322 TIGRFAMs TIGR00553 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00553 UniProtKB PABB_ECOLI http://www.uniprot.org/uniprot/PABB_ECOLI UniProtKB-AC P05041 http://www.uniprot.org/uniprot/P05041 charge swissprot:PABB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PABB_ECOLI eggNOG COG0147 http://eggnogapi.embl.de/nog_data/html/tree/COG0147 eggNOG ENOG4105CRQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CRQ epestfind swissprot:PABB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PABB_ECOLI garnier swissprot:PABB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PABB_ECOLI helixturnhelix swissprot:PABB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PABB_ECOLI hmoment swissprot:PABB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PABB_ECOLI iep swissprot:PABB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PABB_ECOLI inforesidue swissprot:PABB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PABB_ECOLI octanol swissprot:PABB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PABB_ECOLI pepcoil swissprot:PABB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PABB_ECOLI pepdigest swissprot:PABB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PABB_ECOLI pepinfo swissprot:PABB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PABB_ECOLI pepnet swissprot:PABB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PABB_ECOLI pepstats swissprot:PABB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PABB_ECOLI pepwheel swissprot:PABB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PABB_ECOLI pepwindow swissprot:PABB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PABB_ECOLI sigcleave swissprot:PABB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PABB_ECOLI ## Database ID URL or Descriptions # BioGrid 4262949 14 # EcoGene EG12940 ygaH # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_function GO:0005304 L-valine transmembrane transporter activity; IMP:EcoCyc. # GO_function GO:0015562 efflux transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0015829 valine transport; IMP:EcoCyc. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR008407 Brnchd-chn_aa_trnsp_AzlD # Organism YGAH_ECOLI Escherichia coli (strain K12) # PATRIC 32120758 VBIEscCol129921_2776 # PIR D65048 D65048 # Pfam PF05437 AzlD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGAH_ECOLI Uncharacterized protein YgaH # RefSeq NP_417168 NC_000913.3 # RefSeq WP_000119763 NZ_LN832404.1 # TCDB 2.A.78.1 the branched chain amino acid exporter (liv-e) family # eggNOG ENOG4105ZED Bacteria # eggNOG ENOG4111UT4 LUCA BLAST swissprot:YGAH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGAH_ECOLI BioCyc ECOL316407:JW2658-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2658-MONOMER BioCyc EcoCyc:G7406-MONOMER http://biocyc.org/getid?id=EcoCyc:G7406-MONOMER BioCyc MetaCyc:G7406-MONOMER http://biocyc.org/getid?id=MetaCyc:G7406-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U19993 http://www.ebi.ac.uk/ena/data/view/U19993 EchoBASE EB2775 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2775 EcoGene EG12940 http://www.ecogene.org/geneInfo.php?eg_id=EG12940 EnsemblBacteria AAC75730 http://www.ensemblgenomes.org/id/AAC75730 EnsemblBacteria AAC75730 http://www.ensemblgenomes.org/id/AAC75730 EnsemblBacteria BAA16545 http://www.ensemblgenomes.org/id/BAA16545 EnsemblBacteria BAA16545 http://www.ensemblgenomes.org/id/BAA16545 EnsemblBacteria BAA16545 http://www.ensemblgenomes.org/id/BAA16545 EnsemblBacteria b2683 http://www.ensemblgenomes.org/id/b2683 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0005304 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005304 GO_function GO:0015562 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015562 GO_process GO:0015829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 945111 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945111 HOGENOM HOG000124014 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000124014&db=HOGENOM6 InterPro IPR008407 http://www.ebi.ac.uk/interpro/entry/IPR008407 KEGG_Gene ecj:JW2658 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2658 KEGG_Gene eco:b2683 http://www.genome.jp/dbget-bin/www_bget?eco:b2683 OMA LCFYKTR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LCFYKTR PSORT swissprot:YGAH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGAH_ECOLI PSORT-B swissprot:YGAH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGAH_ECOLI PSORT2 swissprot:YGAH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGAH_ECOLI Pfam PF05437 http://pfam.xfam.org/family/PF05437 Phobius swissprot:YGAH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGAH_ECOLI ProteinModelPortal P43667 http://www.proteinmodelportal.org/query/uniprot/P43667 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7730261 http://www.ncbi.nlm.nih.gov/pubmed/7730261 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417168 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417168 RefSeq WP_000119763 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000119763 STRING 511145.b2683 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2683&targetmode=cogs TCDB 2.A.78.1 http://www.tcdb.org/search/result.php?tc=2.A.78.1 UniProtKB YGAH_ECOLI http://www.uniprot.org/uniprot/YGAH_ECOLI UniProtKB-AC P43667 http://www.uniprot.org/uniprot/P43667 charge swissprot:YGAH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGAH_ECOLI eggNOG ENOG4105ZED http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ZED eggNOG ENOG4111UT4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111UT4 epestfind swissprot:YGAH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGAH_ECOLI garnier swissprot:YGAH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGAH_ECOLI helixturnhelix swissprot:YGAH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGAH_ECOLI hmoment swissprot:YGAH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGAH_ECOLI iep swissprot:YGAH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGAH_ECOLI inforesidue swissprot:YGAH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGAH_ECOLI octanol swissprot:YGAH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGAH_ECOLI pepcoil swissprot:YGAH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGAH_ECOLI pepdigest swissprot:YGAH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGAH_ECOLI pepinfo swissprot:YGAH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGAH_ECOLI pepnet swissprot:YGAH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGAH_ECOLI pepstats swissprot:YGAH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGAH_ECOLI pepwheel swissprot:YGAH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGAH_ECOLI pepwindow swissprot:YGAH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGAH_ECOLI sigcleave swissprot:YGAH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGAH_ECOLI ## Database ID URL or Descriptions # AltName LPF2_ECOLI PheST attenuator peptide # EcoGene EG11272 pheM # GO_process GO:0006355 regulation of transcription, DNA-templated; IMP:EcoCyc. # GOslim_process GO:0008150 biological_process # Organism LPF2_ECOLI Escherichia coli (strain K12) # PIR S11551 LFECFS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LPF2_ECOLI Phenylalanyl--tRNA ligase operon leader peptide # RefSeq NP_416230 NC_000913.3 BLAST swissprot:LPF2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LPF2_ECOLI BioCyc ECOL316407:JW1705-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1705-MONOMER BioCyc EcoCyc:EG11272-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11272-MONOMER DOI 10.1016/0022-2836(83)90092-X http://dx.doi.org/10.1016/0022-2836(83)90092-X DOI 10.1016/0022-2836(85)90420-6 http://dx.doi.org/10.1016/0022-2836(85)90420-6 DOI 10.1016/0300-9084(87)90006-X http://dx.doi.org/10.1016/0300-9084(87)90006-X DOI 10.1016/0378-1119(84)90114-8 http://dx.doi.org/10.1016/0378-1119(84)90114-8 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M10423 http://www.ebi.ac.uk/ena/data/view/M10423 EMBL M13251 http://www.ebi.ac.uk/ena/data/view/M13251 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL V00291 http://www.ebi.ac.uk/ena/data/view/V00291 EchoBASE EB1251 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1251 EcoGene EG11272 http://www.ecogene.org/geneInfo.php?eg_id=EG11272 EnsemblBacteria AAC74785 http://www.ensemblgenomes.org/id/AAC74785 EnsemblBacteria AAC74785 http://www.ensemblgenomes.org/id/AAC74785 EnsemblBacteria BAE76506 http://www.ensemblgenomes.org/id/BAE76506 EnsemblBacteria BAE76506 http://www.ensemblgenomes.org/id/BAE76506 EnsemblBacteria BAE76506 http://www.ensemblgenomes.org/id/BAE76506 EnsemblBacteria b1715 http://www.ensemblgenomes.org/id/b1715 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0006355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006355 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 947212 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947212 KEGG_Gene ecj:JW1705 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1705 KEGG_Gene eco:b1715 http://www.genome.jp/dbget-bin/www_bget?eco:b1715 PSORT swissprot:LPF2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LPF2_ECOLI PSORT-B swissprot:LPF2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LPF2_ECOLI PSORT2 swissprot:LPF2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LPF2_ECOLI Phobius swissprot:LPF2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LPF2_ECOLI PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3126825 http://www.ncbi.nlm.nih.gov/pubmed/3126825 PubMed 3158742 http://www.ncbi.nlm.nih.gov/pubmed/3158742 PubMed 6096210 http://www.ncbi.nlm.nih.gov/pubmed/6096210 PubMed 6317865 http://www.ncbi.nlm.nih.gov/pubmed/6317865 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416230 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416230 UniProtKB LPF2_ECOLI http://www.uniprot.org/uniprot/LPF2_ECOLI UniProtKB-AC P0AD74 http://www.uniprot.org/uniprot/P0AD74 charge swissprot:LPF2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LPF2_ECOLI epestfind swissprot:LPF2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LPF2_ECOLI garnier swissprot:LPF2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LPF2_ECOLI helixturnhelix swissprot:LPF2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LPF2_ECOLI hmoment swissprot:LPF2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LPF2_ECOLI iep swissprot:LPF2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LPF2_ECOLI inforesidue swissprot:LPF2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LPF2_ECOLI octanol swissprot:LPF2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LPF2_ECOLI pepcoil swissprot:LPF2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LPF2_ECOLI pepdigest swissprot:LPF2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LPF2_ECOLI pepinfo swissprot:LPF2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LPF2_ECOLI pepnet swissprot:LPF2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LPF2_ECOLI pepstats swissprot:LPF2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LPF2_ECOLI pepwheel swissprot:LPF2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LPF2_ECOLI pepwindow swissprot:LPF2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LPF2_ECOLI sigcleave swissprot:LPF2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LPF2_ECOLI ## Database ID URL or Descriptions # AltName Alpha-keto-beta-hydroxylacyl reductoisomerase {ECO:0000255|HAMAP-Rule MF_00435} # AltName ILVC_ECOLI Acetohydroxy-acid isomeroreductase {ECO 0000255|HAMAP-Rule MF_00435, ECO 0000303|PubMed 2653423} # AltName ILVC_ECOLI Ketol-acid reductoisomerase type 2 {ECO 0000255|HAMAP-Rule MF_00435, ECO 0000303|PubMed 16322583} # AltName ILVC_ECOLI Ketol-acid reductoisomerase type II {ECO 0000255|HAMAP-Rule MF_00435, ECO 0000303|PubMed 16322583} # BIOPHYSICOCHEMICAL PROPERTIES ILVC_ECOLI Kinetic parameters KM=0.04 mM for NADPH {ECO 0000269|PubMed 21515217}; KM=0.042 mM for NADP {ECO 0000269|PubMed 9015391}; KM=0.073 mM for NADPH {ECO 0000269|PubMed 9015391}; KM=0.17 mM for 2-ketopantoate (at pH 8 and 37 degrees Celsius) {ECO 0000269|PubMed 15654896}; KM=0.206 mM for NADH {ECO 0000269|PubMed 9015391}; KM=0.21 mM for 3-hydroxy-2-ketobutyrate (at pH 8 and 37 degrees Celsius) {ECO 0000269|PubMed 15654896}; KM=0.25 mM for 2-acetolactate (at pH 8 and 37 degrees Celsius) {ECO 0000269|PubMed 15654896}; KM=0.27 mM for 3-hydroxy-3-methyl-2-ketobutyrate (at pH 8 and 37 degrees Celsius) {ECO 0000269|PubMed 15654896}; KM=0.42 mM for magnesium (with S2AL and NADPH as substrates) {ECO 0000269|PubMed 2653423}; KM=1.08 mM for NADH {ECO 0000269|PubMed 21515217}; KM=1.54 mM for pyruvate (at pH 8 and 37 degrees Celsius) {ECO 0000269|PubMed 2653423}; KM=2.96 mM for 3-hydroxypyruvate (at pH 8 and 37 degrees Celsius) {ECO 0000269|PubMed 2653423}; KM=3.15 mM for 2-ketovalerate (at pH 8 and 37 degrees Celsius) {ECO 0000269|PubMed 2653423}; KM=4.56 mM for 2-ketobutyrate (at pH 8 and 37 degrees Celsius) {ECO 0000269|PubMed 2653423}; KM=6.91 mM for 2-ketoisovalerate (at pH 8 and 37 degrees Celsius) {ECO 0000269|PubMed 2653423}; Vmax=5.421 umol/min/mg enzyme with 3-hydroxypyruvate as substrate (at pH 8 and 37 degrees Celsius) {ECO 0000269|PubMed 15654896}; Vmax=3.541 umol/min/mg enzyme with 3-hydroxy-3-methyl-2- ketobutyrate as substrate (at pH 8 and 37 degrees Celsius) {ECO 0000269|PubMed 15654896}; Vmax=2.25 umol/min/mg enzyme with 2-acetolactate as substrate (at pH 8 and 37 degrees Celsius) {ECO 0000269|PubMed 15654896}; Vmax=0.599 umol/min/mg enzyme with 3-hydroxy-2-ketobutyrate as substrate (at pH 8 and 37 degrees Celsius) {ECO 0000269|PubMed 15654896}; Vmax=0.196 umol/min/mg enzyme with 2-ketopantoate as substrate (at pH 8 and 37 degrees Celsius) {ECO 0000269|PubMed 15654896}; Vmax=0.184 umol/min/mg enzyme with 2-ketoisovalerate as substrate (at pH 8 and 37 degrees Celsius) {ECO 0000269|PubMed 15654896}; Vmax=0.168 umol/min/mg enzyme with 2-ketobutyrate as substrate (at pH 8 and 37 degrees Celsius) {ECO 0000269|PubMed 15654896}; Vmax=0.05 umol/min/mg enzyme with 2-ketovalerate as substrate (at pH 8 and 37 degrees Celsius) {ECO 0000269|PubMed 15654896}; Vmax=0.021 umol/min/mg enzyme with pyruvate as substrate (at pH 8 and 37 degrees Celsius) {ECO 0000269|PubMed 15654896}; Note=Kcat is 7.2 min(-1) for reductoisomerase activity with NADPH as substrate (PubMed 9015391). Kcat is 3.1 min(-1) for reductoisomerase activity with NADPH as substrate (PubMed 9015391). Kcat is 0.11 min(-1) for reductoisomerase activity with NADH as substrate (PubMed 9015391). Kcat is 5.376 sec(-1) for reductoisomerase activity with 3-hydroxypyruvate as substrate (at pH 8 and 37 degrees Celsius) (PubMed 15654896). Kcat is 3.6 sec(-1) for reductoisomerase activity with NADPH as substrate (PubMed 21515217). Kcat is 3.511 sec(-1) for reductoisomerase activity with 3-hydroxy-3-methyl-2-ketobutyrate as substrate (at pH 8 and 37 degrees Celsius) (PubMed 15654896). Kcat is 2.231 sec(-1) for reductoisomerase activity with 2- acetolactate as substrate (at pH 8 and 37 degrees Celsius) (PubMed 15654896). Kcat is 0.594 sec(-1) for reductoisomerase activity with 3-hydroxy-2-ketobutyrate as substrate (at pH 8 and 37 degrees Celsius) (PubMed 15654896). Kcat is 0.3 sec(-1) for reductoisomerase activity with NADH as substrate (PubMed 21515217). Kcat is 0.194 sec(-1) for reductoisomerase activity with 2-ketopantoate as substrate (at pH 8 and 37 degrees Celsius) (PubMed 15654896). Kcat is 0.182 sec(-1) for reductoisomerase activity with 2-ketoisovalerate as substrate (at pH 8 and 37 degrees Celsius) (PubMed 15654896). Kcat is 0.167 sec(-1) for reductoisomerase activity with 2-ketobutyrate as substrate (at pH 8 and 37 degrees Celsius) (PubMed 15654896). Kcat is 0.05 sec(-1) for reductoisomerase activity with 2- ketovalerate as substrate (at pH 8 and 37 degrees Celsius) (PubMed 15654896). Kcat is 0.021 sec(-1) for reductoisomerase activity with pyruvate as substrate (at pH 8 and 37 degrees Celsius) (PubMed 15654896). {ECO 0000269|PubMed 15654896, ECO 0000269|PubMed 21515217, ECO 0000269|PubMed 9015391}; # BRENDA 1.1.1.86 2026 # BioGrid 4263331 5 # CATALYTIC ACTIVITY (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. {ECO:0000255|HAMAP-Rule MF_00435}. # CATALYTIC ACTIVITY ILVC_ECOLI (2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. {ECO 0000255|HAMAP-Rule MF_00435, ECO 0000269|PubMed 15654896, ECO 0000269|PubMed 21515217, ECO 0000269|PubMed 2653423, ECO 0000269|PubMed 9015391}. # COFACTOR ILVC_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_00435, ECO 0000269|PubMed 15654896, ECO 0000269|PubMed 23036858, ECO 0000269|PubMed 2653423}; Note=Binds 2 magnesium ions per subunit. {ECO 0000255|HAMAP- Rule MF_00435, ECO 0000269|PubMed 23036858, ECO 0000269|PubMed 2653423}; # ENZYME REGULATION Inhibited by N-hydroxy-N-isopropyloxamate (IpOHA). {ECO:0000269|PubMed 2189496}. # EcoGene EG10495 ilvC # FUNCTION ILVC_ECOLI Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. Also able to use 2- ketopantoate, 2-ketoisovalerate, 2-ketovalerate, 2-ketobutyrate, 3-hydroxypyruvate, 3-hydroxy-2-ketobutyrate and pyruvate (PubMed 15654896). {ECO 0000269|PubMed 15654896, ECO 0000269|PubMed 21515217, ECO 0000269|PubMed 2653423, ECO 0000269|PubMed 9015391}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IDA:UniProtKB. # GO_function GO:0004455 ketol-acid reductoisomerase activity; IDA:UniProtKB. # GO_function GO:0050661 NADP binding; IDA:UniProtKB. # GO_process GO:0009097 isoleucine biosynthetic process; IDA:EcoCyc. # GO_process GO:0009099 valine biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 1.10.1040.10 -; 1. # Gene3D 3.40.50.720 -; 1. # HAMAP MF_00435 IlvC # INDUCTION ILVC_ECOLI In the presence of acetohydroxybutyrate and acetolactate and by the activator IlvY. {ECO 0000269|PubMed 3003115, ECO 0000269|PubMed 3062177}. # IntAct P05793 4 # InterPro IPR000506 AcH_isomrdctse_C # InterPro IPR008927 6-PGluconate_DH_C-like # InterPro IPR013023 Ketol-acid_reductoisomrdctse # InterPro IPR013116 IlvN # InterPro IPR013328 6PGD_dom_2 # InterPro IPR016040 NAD(P)-bd_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00290 Valine, leucine and isoleucine biosynthesis # KEGG_Pathway ko00770 Pantothenate and CoA biosynthesis # Organism ILVC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR21371 PTHR21371 # PATHWAY ILVC_ECOLI Amino-acid biosynthesis; L-isoleucine biosynthesis; L- isoleucine from 2-oxobutanoate step 2/4. {ECO 0000255|HAMAP- Rule MF_00435, ECO 0000305|PubMed 2653423}. # PATHWAY ILVC_ECOLI Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate step 2/4. {ECO 0000255|HAMAP-Rule MF_00435, ECO 0000305|PubMed 2653423}. # PATRIC 32123043 VBIEscCol129921_3891 # PDB 1YRL X-ray; 2.60 A; A/B/C/D=1-491 # PDB 3ULK X-ray; 2.30 A; A/B=1-491 # PIR A65181 ISECKR # Pfam PF01450 IlvC; 2 # Pfam PF07991 IlvN # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ILVC_ECOLI Ketol-acid reductoisomerase (NADP(+)) {ECO 0000255|HAMAP-Rule MF_00435, ECO 0000303|PubMed 2653423} # RefSeq NP_418222 NC_000913.3 # RefSeq WP_000024939 NZ_LN832404.1 # SIMILARITY Belongs to the ketol-acid reductoisomerase family. {ECO:0000255|HAMAP-Rule MF_00435}. # SIMILARITY Contains 1 IlvN domain. {ECO:0000255|HAMAP- Rule MF_00435}. # SIMILARITY Contains 2 IlvC domains. {ECO:0000255|HAMAP- Rule MF_00435}. # SUBCELLULAR LOCATION ILVC_ECOLI Cytoplasm {ECO 0000305|PubMed 2653423}. # SUBUNIT ILVC_ECOLI Homotetramer. {ECO 0000269|PubMed 16322583, ECO 0000269|PubMed 23036858}. # SUPFAM SSF48179 SSF48179; 2 # SUPFAM SSF51735 SSF51735 # TIGRFAMs TIGR00465 ilvC # UniPathway UPA00047 UER00056 # UniPathway UPA00049 UER00060 # eggNOG COG0059 LUCA # eggNOG ENOG4105C6M Bacteria BLAST swissprot:ILVC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ILVC_ECOLI BioCyc ECOL316407:JW3747-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3747-MONOMER BioCyc EcoCyc:KETOLREDUCTOISOM-MONOMER http://biocyc.org/getid?id=EcoCyc:KETOLREDUCTOISOM-MONOMER BioCyc MetaCyc:KETOLREDUCTOISOM-MONOMER http://biocyc.org/getid?id=MetaCyc:KETOLREDUCTOISOM-MONOMER COG COG0059 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0059 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/abbi.1996.9802 http://dx.doi.org/10.1006/abbi.1996.9802 DOI 10.1016/0022-2836(88)90199-4 http://dx.doi.org/10.1016/0022-2836(88)90199-4 DOI 10.1016/j.jmb.2012.09.018 http://dx.doi.org/10.1016/j.jmb.2012.09.018 DOI 10.1016/j.ymben.2011.02.004 http://dx.doi.org/10.1016/j.ymben.2011.02.004 DOI 10.1021/bi00428a012 http://dx.doi.org/10.1021/bi00428a012 DOI 10.1021/bi00463a027 http://dx.doi.org/10.1021/bi00463a027 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1110/ps.051791305 http://dx.doi.org/10.1110/ps.051791305 DOI 10.1111/j.1742-4658.2004.04506.x http://dx.doi.org/10.1111/j.1742-4658.2004.04506.x DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.86 {ECO:0000255|HAMAP-Rule:MF_00435, ECO:0000269|PubMed:15654896, ECO:0000269|PubMed:21515217, ECO:0000269|PubMed:2653423, ECO:0000269|PubMed:9015391} http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.86 {ECO:0000255|HAMAP-Rule:MF_00435, ECO:0000269|PubMed:15654896, ECO:0000269|PubMed:21515217, ECO:0000269|PubMed:2653423, ECO:0000269|PubMed:9015391} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M11689 http://www.ebi.ac.uk/ena/data/view/M11689 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.1.1.86 {ECO:0000255|HAMAP-Rule:MF_00435, ECO:0000269|PubMed:15654896, ECO:0000269|PubMed:21515217, ECO:0000269|PubMed:2653423, ECO:0000269|PubMed:9015391} http://enzyme.expasy.org/EC/1.1.1.86 {ECO:0000255|HAMAP-Rule:MF_00435, ECO:0000269|PubMed:15654896, ECO:0000269|PubMed:21515217, ECO:0000269|PubMed:2653423, ECO:0000269|PubMed:9015391} EchoBASE EB0490 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0490 EcoGene EG10495 http://www.ecogene.org/geneInfo.php?eg_id=EG10495 EnsemblBacteria AAC76779 http://www.ensemblgenomes.org/id/AAC76779 EnsemblBacteria AAC76779 http://www.ensemblgenomes.org/id/AAC76779 EnsemblBacteria BAE77523 http://www.ensemblgenomes.org/id/BAE77523 EnsemblBacteria BAE77523 http://www.ensemblgenomes.org/id/BAE77523 EnsemblBacteria BAE77523 http://www.ensemblgenomes.org/id/BAE77523 EnsemblBacteria b3774 http://www.ensemblgenomes.org/id/b3774 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0004455 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004455 GO_function GO:0050661 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050661 GO_process GO:0009097 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009097 GO_process GO:0009099 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009099 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 1.10.1040.10 http://www.cathdb.info/version/latest/superfamily/1.10.1040.10 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 948286 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948286 HAMAP MF_00435 http://hamap.expasy.org/unirule/MF_00435 HOGENOM HOG000286135 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000286135&db=HOGENOM6 InParanoid P05793 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P05793 IntAct P05793 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P05793* IntEnz 1.1.1.86 {ECO:0000255|HAMAP-Rule:MF_00435, ECO:0000269|PubMed:15654896, ECO:0000269|PubMed:21515217, ECO:0000269|PubMed:2653423, ECO:0000269|PubMed:9015391} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.86 {ECO:0000255|HAMAP-Rule:MF_00435, ECO:0000269|PubMed:15654896, ECO:0000269|PubMed:21515217, ECO:0000269|PubMed:2653423, ECO:0000269|PubMed:9015391} InterPro IPR000506 http://www.ebi.ac.uk/interpro/entry/IPR000506 InterPro IPR008927 http://www.ebi.ac.uk/interpro/entry/IPR008927 InterPro IPR013023 http://www.ebi.ac.uk/interpro/entry/IPR013023 InterPro IPR013116 http://www.ebi.ac.uk/interpro/entry/IPR013116 InterPro IPR013328 http://www.ebi.ac.uk/interpro/entry/IPR013328 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3747 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3747 KEGG_Gene eco:b3774 http://www.genome.jp/dbget-bin/www_bget?eco:b3774 KEGG_Orthology KO:K00053 http://www.genome.jp/dbget-bin/www_bget?KO:K00053 KEGG_Pathway ko00290 http://www.genome.jp/kegg-bin/show_pathway?ko00290 KEGG_Pathway ko00770 http://www.genome.jp/kegg-bin/show_pathway?ko00770 KEGG_Reaction rn:R03051 http://www.genome.jp/dbget-bin/www_bget?rn:R03051 KEGG_Reaction rn:R04440 http://www.genome.jp/dbget-bin/www_bget?rn:R04440 KEGG_Reaction rn:R05068 http://www.genome.jp/dbget-bin/www_bget?rn:R05068 KEGG_Reaction rn:R05069 http://www.genome.jp/dbget-bin/www_bget?rn:R05069 KEGG_Reaction rn:R05071 http://www.genome.jp/dbget-bin/www_bget?rn:R05071 OMA KLFEMNR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KLFEMNR PANTHER PTHR21371 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21371 PDB 1YRL http://www.ebi.ac.uk/pdbe-srv/view/entry/1YRL PDB 3ULK http://www.ebi.ac.uk/pdbe-srv/view/entry/3ULK PDBsum 1YRL http://www.ebi.ac.uk/pdbsum/1YRL PDBsum 3ULK http://www.ebi.ac.uk/pdbsum/3ULK PSORT swissprot:ILVC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ILVC_ECOLI PSORT-B swissprot:ILVC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ILVC_ECOLI PSORT2 swissprot:ILVC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ILVC_ECOLI Pfam PF01450 http://pfam.xfam.org/family/PF01450 Pfam PF07991 http://pfam.xfam.org/family/PF07991 Phobius swissprot:ILVC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ILVC_ECOLI PhylomeDB P05793 http://phylomedb.org/?seqid=P05793 ProteinModelPortal P05793 http://www.proteinmodelportal.org/query/uniprot/P05793 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 15654896 http://www.ncbi.nlm.nih.gov/pubmed/15654896 PubMed 16322583 http://www.ncbi.nlm.nih.gov/pubmed/16322583 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 21515217 http://www.ncbi.nlm.nih.gov/pubmed/21515217 PubMed 2189496 http://www.ncbi.nlm.nih.gov/pubmed/2189496 PubMed 23036858 http://www.ncbi.nlm.nih.gov/pubmed/23036858 PubMed 2653423 http://www.ncbi.nlm.nih.gov/pubmed/2653423 PubMed 3003115 http://www.ncbi.nlm.nih.gov/pubmed/3003115 PubMed 3062177 http://www.ncbi.nlm.nih.gov/pubmed/3062177 PubMed 9015391 http://www.ncbi.nlm.nih.gov/pubmed/9015391 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_418222 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418222 RefSeq WP_000024939 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000024939 SMR P05793 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P05793 STRING 511145.b3774 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3774&targetmode=cogs STRING COG0059 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0059&targetmode=cogs SUPFAM SSF48179 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48179 SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 SWISS-2DPAGE P05793 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P05793 TIGRFAMs TIGR00465 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00465 UniProtKB ILVC_ECOLI http://www.uniprot.org/uniprot/ILVC_ECOLI UniProtKB-AC P05793 http://www.uniprot.org/uniprot/P05793 charge swissprot:ILVC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ILVC_ECOLI eggNOG COG0059 http://eggnogapi.embl.de/nog_data/html/tree/COG0059 eggNOG ENOG4105C6M http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C6M epestfind swissprot:ILVC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ILVC_ECOLI garnier swissprot:ILVC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ILVC_ECOLI helixturnhelix swissprot:ILVC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ILVC_ECOLI hmoment swissprot:ILVC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ILVC_ECOLI iep swissprot:ILVC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ILVC_ECOLI inforesidue swissprot:ILVC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ILVC_ECOLI octanol swissprot:ILVC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ILVC_ECOLI pepcoil swissprot:ILVC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ILVC_ECOLI pepdigest swissprot:ILVC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ILVC_ECOLI pepinfo swissprot:ILVC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ILVC_ECOLI pepnet swissprot:ILVC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ILVC_ECOLI pepstats swissprot:ILVC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ILVC_ECOLI pepwheel swissprot:ILVC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ILVC_ECOLI pepwindow swissprot:ILVC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ILVC_ECOLI sigcleave swissprot:ILVC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ILVC_ECOLI ## Database ID URL or Descriptions # AltName Ferric hydroxamate uptake protein C {ECO 0000305} # AltName Ferrichrome transport ATP-binding protein FhuC {ECO 0000305} # AltName Iron(III)-hydroxamate import ATP-binding protein FhuC {ECO 0000305} # BioGrid 4261072 351 # CATALYTIC ACTIVITY ATP + H(2)O + iron chelate(Out) = ADP + phosphate + iron chelate(In). {ECO:0000269|PubMed 1551849}. # EcoGene EG10304 fhuC # FUNCTION FHUC_ECOLI Part of the ABC transporter complex FhuCDB involved in iron(3+)-hydroxamate import. Responsible for energy coupling to the transport system. {ECO 0000269|PubMed 1551849}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0015623 iron-chelate-transporting ATPase activity; IEA:UniProtKB-EC. # GO_process GO:0006811 ion transport; IEA:UniProtKB-KW. # GO_process GO:0055072 iron ion homeostasis; IEA:UniProtKB-KW. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # GOslim_process GO:0042592 homeostatic process # Gene3D 3.40.50.300 -; 1. # INDUCTION Induced 1.6-fold by hydroxyurea. {ECO:0000269|PubMed 20005847}. # IntAct P07821 5 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00240 Iron complex transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism FHUC_ECOLI Escherichia coli (strain K12) # PATRIC 32115411 VBIEscCol129921_0157 # PIR G64738 QRECFH # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # Pfam PF00005 ABC_tran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Iron(3+)-hydroxamate import ATP-binding protein FhuC {ECO 0000305} # RefSeq NP_414693 NC_000913.3 # RefSeq WP_001158931 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. Iron (Fe3+)-hydroxamate importer (TC 3.A.1.14.7) family. {ECO 0000305}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA # SUBCELLULAR LOCATION FHUC_ECOLI Cell inner membrane {ECO 0000269|PubMed 1551849}; Peripheral membrane protein {ECO 0000269|PubMed 1551849}. Note=FhuB mediates the association of FhuC with the cytoplasmic membrane. {ECO 0000269|PubMed 1551849}. # SUBUNIT FHUC_ECOLI The complex is composed of two ATP-binding proteins (FhuC), two transmembrane proteins (FhuB) and a solute-binding protein (FhuD) (Probable). FhuC interacts with FhuB (PubMed 1551849). {ECO 0000269|PubMed 1551849, ECO 0000305}. # SUPFAM SSF52540 SSF52540 # TCDB 3.A.1.14 the atp-binding cassette (abc) superfamily # eggNOG COG1120 LUCA # eggNOG ENOG4105E0A Bacteria BLAST swissprot:FHUC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FHUC_ECOLI BioCyc ECOL316407:JW0147-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0147-MONOMER BioCyc EcoCyc:FHUC-MONOMER http://biocyc.org/getid?id=EcoCyc:FHUC-MONOMER BioCyc MetaCyc:FHUC-MONOMER http://biocyc.org/getid?id=MetaCyc:FHUC-MONOMER COG COG1120 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1120 DOI 10.1007/BF00329835 http://dx.doi.org/10.1007/BF00329835 DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.6.3.34 {ECO:0000269|PubMed:1551849} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.34 {ECO:0000269|PubMed:1551849} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M12486 http://www.ebi.ac.uk/ena/data/view/M12486 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EMBL X05810 http://www.ebi.ac.uk/ena/data/view/X05810 ENZYME 3.6.3.34 {ECO:0000269|PubMed:1551849} http://enzyme.expasy.org/EC/3.6.3.34 {ECO:0000269|PubMed:1551849} EchoBASE EB0300 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0300 EcoGene EG10304 http://www.ecogene.org/geneInfo.php?eg_id=EG10304 EnsemblBacteria AAC73262 http://www.ensemblgenomes.org/id/AAC73262 EnsemblBacteria AAC73262 http://www.ensemblgenomes.org/id/AAC73262 EnsemblBacteria BAB96727 http://www.ensemblgenomes.org/id/BAB96727 EnsemblBacteria BAB96727 http://www.ensemblgenomes.org/id/BAB96727 EnsemblBacteria BAB96727 http://www.ensemblgenomes.org/id/BAB96727 EnsemblBacteria b0151 http://www.ensemblgenomes.org/id/b0151 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0015623 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015623 GO_process GO:0006811 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811 GO_process GO:0055072 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055072 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945250 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945250 InParanoid P07821 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P07821 IntAct P07821 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P07821* IntEnz 3.6.3.34 {ECO:0000269|PubMed:1551849} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.34 {ECO:0000269|PubMed:1551849} InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0147 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0147 KEGG_Gene eco:b0151 http://www.genome.jp/dbget-bin/www_bget?eco:b0151 KEGG_Orthology KO:K02013 http://www.genome.jp/dbget-bin/www_bget?KO:K02013 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA MLGRHQK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MLGRHQK PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:FHUC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FHUC_ECOLI PSORT-B swissprot:FHUC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FHUC_ECOLI PSORT2 swissprot:FHUC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FHUC_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Phobius swissprot:FHUC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FHUC_ECOLI PhylomeDB P07821 http://phylomedb.org/?seqid=P07821 ProteinModelPortal P07821 http://www.proteinmodelportal.org/query/uniprot/P07821 PubMed 1551849 http://www.ncbi.nlm.nih.gov/pubmed/1551849 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 2823072 http://www.ncbi.nlm.nih.gov/pubmed/2823072 PubMed 3301821 http://www.ncbi.nlm.nih.gov/pubmed/3301821 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414693 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414693 RefSeq WP_001158931 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001158931 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P07821 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P07821 STRING 511145.b0151 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0151&targetmode=cogs STRING COG1120 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1120&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.14 http://www.tcdb.org/search/result.php?tc=3.A.1.14 UniProtKB FHUC_ECOLI http://www.uniprot.org/uniprot/FHUC_ECOLI UniProtKB-AC P07821 http://www.uniprot.org/uniprot/P07821 charge swissprot:FHUC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FHUC_ECOLI eggNOG COG1120 http://eggnogapi.embl.de/nog_data/html/tree/COG1120 eggNOG ENOG4105E0A http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E0A epestfind swissprot:FHUC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FHUC_ECOLI garnier swissprot:FHUC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FHUC_ECOLI helixturnhelix swissprot:FHUC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FHUC_ECOLI hmoment swissprot:FHUC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FHUC_ECOLI iep swissprot:FHUC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FHUC_ECOLI inforesidue swissprot:FHUC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FHUC_ECOLI octanol swissprot:FHUC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FHUC_ECOLI pepcoil swissprot:FHUC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FHUC_ECOLI pepdigest swissprot:FHUC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FHUC_ECOLI pepinfo swissprot:FHUC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FHUC_ECOLI pepnet swissprot:FHUC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FHUC_ECOLI pepstats swissprot:FHUC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FHUC_ECOLI pepwheel swissprot:FHUC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FHUC_ECOLI pepwindow swissprot:FHUC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FHUC_ECOLI sigcleave swissprot:FHUC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FHUC_ECOLI ## Database ID URL or Descriptions # AltName BLR_ECOLI Beta-lactam resistance protein # BioGrid 4259631 432 # DISRUPTION PHENOTYPE Inactivation increases the susceptibility of bacteria to a number of antibiotics that inhibit peptidoglycan biosynthesis. Increases the susceptibility to cycloserine, bacitracin, and a wide spectrum of beta-lactam antibiotics. Does not affect susceptibility to fosfomycin, valinomycin, tetracycline, chloramphenicol, gentamicin or quinolones. {ECO:0000269|PubMed 10931331}. # EcoGene EG14389 blr # FUNCTION BLR_ECOLI Component of the cell division machinery, which is probably involved in the stabilization of the divisome under certain stress conditions. {ECO 0000269|PubMed 22885295}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IDA:EcoCyc. # GO_component GO:0032153 cell division site; IDA:EcoCyc. # GO_process GO:0007049 cell cycle; IEA:UniProtKB-KW. # GO_process GO:0036460 cellular response to cell envelope stress; IMP:EcoCyc. # GO_process GO:0046677 response to antibiotic; IMP:EcoCyc. # GO_process GO:0051301 cell division; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006950 response to stress # GOslim_process GO:0007049 cell cycle # GOslim_process GO:0008150 biological_process # GOslim_process GO:0051301 cell division # INTERACTION BLR_ECOLI P0AEN4 ftsL; NbExp=3; IntAct=EBI-6419495, EBI-1119082; P29131 ftsN; NbExp=3; IntAct=EBI-6419495, EBI-1134233; # IntAct P56976 8 # Organism BLR_ECOLI Escherichia coli (strain K12) # PTM BLR_ECOLI The N-terminus is blocked. # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BLR_ECOLI Divisome-associated membrane protein Blr # RefSeq WP_001300888 NZ_LN832404.1 # RefSeq YP_025303 NC_000913.3 # SUBCELLULAR LOCATION BLR_ECOLI Cell inner membrane {ECO 0000269|PubMed 10931331, ECO 0000269|PubMed 22885295}; Single-pass membrane protein {ECO 0000269|PubMed 10931331, ECO 0000269|PubMed 22885295}. Note=Localizes to the division septum. Localization requires FtsQ and FtsN. # SUBUNIT Interacts with FtsL and several other divisomal proteins, including FtsI, FtsK, FtsN, FtsQ, FtsW and YmgF. {ECO:0000269|PubMed 22885295}. # eggNOG ENOG4106C6R Bacteria # eggNOG ENOG410Y1ZA LUCA BLAST swissprot:BLR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BLR_ECOLI BioCyc ECOL316407:JW5963-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5963-MONOMER BioCyc EcoCyc:MONOMER0-1561 http://biocyc.org/getid?id=EcoCyc:MONOMER0-1561 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2000.01998.x http://dx.doi.org/10.1046/j.1365-2958.2000.01998.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00774-12 http://dx.doi.org/10.1128/JB.00774-12 EMBL AF219227 http://www.ebi.ac.uk/ena/data/view/AF219227 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14389 http://www.ecogene.org/geneInfo.php?eg_id=EG14389 EnsemblBacteria AAT48132 http://www.ensemblgenomes.org/id/AAT48132 EnsemblBacteria AAT48132 http://www.ensemblgenomes.org/id/AAT48132 EnsemblBacteria BAE76483 http://www.ensemblgenomes.org/id/BAE76483 EnsemblBacteria BAE76483 http://www.ensemblgenomes.org/id/BAE76483 EnsemblBacteria BAE76483 http://www.ensemblgenomes.org/id/BAE76483 EnsemblBacteria b4409 http://www.ensemblgenomes.org/id/b4409 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0032153 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032153 GO_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GO_process GO:0036460 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0036460 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GO_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0007049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007049 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0051301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051301 GeneID 2847682 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2847682 HOGENOM HOG000294500 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000294500&db=HOGENOM6 IntAct P56976 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P56976* KEGG_Gene ecj:JW5963 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5963 KEGG_Gene eco:b4409 http://www.genome.jp/dbget-bin/www_bget?eco:b4409 PSORT swissprot:BLR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BLR_ECOLI PSORT-B swissprot:BLR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BLR_ECOLI PSORT2 swissprot:BLR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BLR_ECOLI Phobius swissprot:BLR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BLR_ECOLI ProteinModelPortal P56976 http://www.proteinmodelportal.org/query/uniprot/P56976 PubMed 10931331 http://www.ncbi.nlm.nih.gov/pubmed/10931331 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22885295 http://www.ncbi.nlm.nih.gov/pubmed/22885295 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001300888 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300888 RefSeq YP_025303 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_025303 STRING 511145.b4409 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4409&targetmode=cogs UniProtKB BLR_ECOLI http://www.uniprot.org/uniprot/BLR_ECOLI UniProtKB-AC P56976 http://www.uniprot.org/uniprot/P56976 charge swissprot:BLR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BLR_ECOLI eggNOG ENOG4106C6R http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106C6R eggNOG ENOG410Y1ZA http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y1ZA epestfind swissprot:BLR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BLR_ECOLI garnier swissprot:BLR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BLR_ECOLI helixturnhelix swissprot:BLR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BLR_ECOLI hmoment swissprot:BLR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BLR_ECOLI iep swissprot:BLR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BLR_ECOLI inforesidue swissprot:BLR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BLR_ECOLI octanol swissprot:BLR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BLR_ECOLI pepcoil swissprot:BLR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BLR_ECOLI pepdigest swissprot:BLR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BLR_ECOLI pepinfo swissprot:BLR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BLR_ECOLI pepnet swissprot:BLR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BLR_ECOLI pepstats swissprot:BLR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BLR_ECOLI pepwheel swissprot:BLR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BLR_ECOLI pepwindow swissprot:BLR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BLR_ECOLI sigcleave swissprot:BLR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BLR_ECOLI ## Database ID URL or Descriptions # AltName DMA_ECOLI DNA adenine methyltransferase # AltName DMA_ECOLI Deoxyadenosyl-methyltransferase # AltName DMA_ECOLI M.EcoDam # BRENDA 2.1.1.72 2026 # BioGrid 4261860 125 # CATALYTIC ACTIVITY DMA_ECOLI S-adenosyl-L-methionine + adenine in DNA = S- adenosyl-L-homocysteine + N-6-methyladenine in DNA. # EcoGene EG10204 dam # FUNCTION DMA_ECOLI Methylates DNA within the sequence GATC and protects the DNA from cleavage by the restriction endonuclease MboI. Although it shares sequence specificity with a number of type II restriction endonucleases and methylases, it is thought to act in postreplication mismatch repair rather than as a part of a restriction modification system. May also play a role in DNA replication. # GO_function GO:0009007 site-specific DNA-methyltransferase (adenine-specific) activity; IDA:EcoCyc. # GO_function GO:0043565 sequence-specific DNA binding; IDA:EcoCyc. # GO_function GO:1904047 S-adenosyl-L-methionine binding; IDA:EcoCyc. # GO_process GO:0006261 DNA-dependent DNA replication; IMP:EcoliWiki. # GO_process GO:0006298 mismatch repair; IDA:EcoliWiki. # GO_process GO:0032775 DNA methylation on adenine; IMP:EcoCyc. # GO_process GO:1902328 bacterial-type DNA replication initiation; IMP:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # Gene3D 1.10.1020.10 -; 1. # Gene3D 3.40.50.150 -; 2. # IntAct P0AEE8 24 # InterPro IPR002052 DNA_methylase_N6_adenine_CS # InterPro IPR012263 M_m6A_EcoRV # InterPro IPR012327 MeTrfase_D12 # InterPro IPR023095 Ade_MeTrfase_dom_2 # InterPro IPR029063 SAM-dependent_MTases # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03032 DNA replication proteins # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko03430 Mismatch repair # Organism DMA_ECOLI Escherichia coli (strain K12) # PATRIC 32122206 VBIEscCol129921_3480 # PDB 2G1P X-ray; 1.89 A; A/B=1-278 # PDB 2ORE X-ray; 2.99 A; D/E/F=1-278 # PDB 4GBE X-ray; 2.66 A; D/E/F=1-278 # PDB 4GOL X-ray; 2.57 A; D/E/F=1-278 # PDB 4GOM X-ray; 2.45 A; D/E/F=1-278 # PDB 4GON X-ray; 2.72 A; D/E/F=1-278 # PDB 4GOO X-ray; 2.70 A; D/E/F=1-278 # PDB 4RTJ X-ray; 1.99 A; A=1-278 # PDB 4RTK X-ray; 1.96 A; A=1-278 # PDB 4RTL X-ray; 2.19 A; A=1-278 # PDB 4RTM X-ray; 2.50 A; A=1-278 # PDB 4RTN X-ray; 2.59 A; A=1-278 # PDB 4RTO X-ray; 2.69 A; A=1-278 # PDB 4RTP X-ray; 2.39 A; A=1-278 # PDB 4RTQ X-ray; 2.00 A; A=1-278 # PDB 4RTR X-ray; 2.39 A; A=1-278 # PDB 4RTS X-ray; 2.49 A; A=1-278 # PIR A00555 XYECDA # PIRSF PIRSF000398 M_m6A_EcoRV # PRINTS PR00505 D12N6MTFRASE # PROSITE PS00092 N6_MTASE # Pfam PF02086 MethyltransfD12 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # REBASE 2396 M.EcoKDam # RecName DMA_ECOLI DNA adenine methylase # RefSeq NP_417846 NC_000913.3 # RefSeq WP_000742143 NZ_LN832404.1 # SIMILARITY Belongs to the N(4)/N(6)-methyltransferase family. {ECO 0000305}. # SUPFAM SSF53335 SSF53335 # TIGRFAMs TIGR00571 dam # eggNOG COG0338 LUCA # eggNOG ENOG4105DFE Bacteria BLAST swissprot:DMA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DMA_ECOLI BioCyc ECOL316407:JW3350-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3350-MONOMER BioCyc EcoCyc:EG10204-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10204-MONOMER BioCyc MetaCyc:EG10204-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10204-MONOMER COG COG0338 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0338 DIP DIP-47948N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47948N DOI 10.1007/BF00290345 http://dx.doi.org/10.1007/BF00290345 DOI 10.1007/BF00330946 http://dx.doi.org/10.1007/BF00330946 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/11.3.837 http://dx.doi.org/10.1093/nar/11.3.837 DOI 10.1093/nar/21.14.3183 http://dx.doi.org/10.1093/nar/21.14.3183 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.1.72 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.72 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01600 http://www.ebi.ac.uk/ena/data/view/J01600 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL V00272 http://www.ebi.ac.uk/ena/data/view/V00272 EMBL X15162 http://www.ebi.ac.uk/ena/data/view/X15162 EMBL Z19601 http://www.ebi.ac.uk/ena/data/view/Z19601 ENZYME 2.1.1.72 http://enzyme.expasy.org/EC/2.1.1.72 EchoBASE EB0200 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0200 EcoGene EG10204 http://www.ecogene.org/geneInfo.php?eg_id=EG10204 EnsemblBacteria AAC76412 http://www.ensemblgenomes.org/id/AAC76412 EnsemblBacteria AAC76412 http://www.ensemblgenomes.org/id/AAC76412 EnsemblBacteria BAE77904 http://www.ensemblgenomes.org/id/BAE77904 EnsemblBacteria BAE77904 http://www.ensemblgenomes.org/id/BAE77904 EnsemblBacteria BAE77904 http://www.ensemblgenomes.org/id/BAE77904 EnsemblBacteria b3387 http://www.ensemblgenomes.org/id/b3387 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0009007 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009007 GO_function GO:0043565 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043565 GO_function GO:1904047 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1904047 GO_process GO:0006261 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006261 GO_process GO:0006298 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006298 GO_process GO:0032775 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032775 GO_process GO:1902328 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902328 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 1.10.1020.10 http://www.cathdb.info/version/latest/superfamily/1.10.1020.10 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 GeneID 947893 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947893 HOGENOM HOG000281348 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000281348&db=HOGENOM6 InParanoid P0AEE8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AEE8 IntAct P0AEE8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AEE8* IntEnz 2.1.1.72 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.72 InterPro IPR002052 http://www.ebi.ac.uk/interpro/entry/IPR002052 InterPro IPR012263 http://www.ebi.ac.uk/interpro/entry/IPR012263 InterPro IPR012327 http://www.ebi.ac.uk/interpro/entry/IPR012327 InterPro IPR023095 http://www.ebi.ac.uk/interpro/entry/IPR023095 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03032 http://www.genome.jp/dbget-bin/www_bget?ko03032 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW3350 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3350 KEGG_Gene eco:b3387 http://www.genome.jp/dbget-bin/www_bget?eco:b3387 KEGG_Orthology KO:K06223 http://www.genome.jp/dbget-bin/www_bget?KO:K06223 KEGG_Pathway ko03430 http://www.genome.jp/kegg-bin/show_pathway?ko03430 MINT MINT-1230150 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1230150 OMA MNRHGFN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MNRHGFN PDB 2G1P http://www.ebi.ac.uk/pdbe-srv/view/entry/2G1P PDB 2ORE http://www.ebi.ac.uk/pdbe-srv/view/entry/2ORE PDB 4GBE http://www.ebi.ac.uk/pdbe-srv/view/entry/4GBE PDB 4GOL http://www.ebi.ac.uk/pdbe-srv/view/entry/4GOL PDB 4GOM http://www.ebi.ac.uk/pdbe-srv/view/entry/4GOM PDB 4GON http://www.ebi.ac.uk/pdbe-srv/view/entry/4GON PDB 4GOO http://www.ebi.ac.uk/pdbe-srv/view/entry/4GOO PDB 4RTJ http://www.ebi.ac.uk/pdbe-srv/view/entry/4RTJ PDB 4RTK http://www.ebi.ac.uk/pdbe-srv/view/entry/4RTK PDB 4RTL http://www.ebi.ac.uk/pdbe-srv/view/entry/4RTL PDB 4RTM http://www.ebi.ac.uk/pdbe-srv/view/entry/4RTM PDB 4RTN http://www.ebi.ac.uk/pdbe-srv/view/entry/4RTN PDB 4RTO http://www.ebi.ac.uk/pdbe-srv/view/entry/4RTO PDB 4RTP http://www.ebi.ac.uk/pdbe-srv/view/entry/4RTP PDB 4RTQ http://www.ebi.ac.uk/pdbe-srv/view/entry/4RTQ PDB 4RTR http://www.ebi.ac.uk/pdbe-srv/view/entry/4RTR PDB 4RTS http://www.ebi.ac.uk/pdbe-srv/view/entry/4RTS PDBsum 2G1P http://www.ebi.ac.uk/pdbsum/2G1P PDBsum 2ORE http://www.ebi.ac.uk/pdbsum/2ORE PDBsum 4GBE http://www.ebi.ac.uk/pdbsum/4GBE PDBsum 4GOL http://www.ebi.ac.uk/pdbsum/4GOL PDBsum 4GOM http://www.ebi.ac.uk/pdbsum/4GOM PDBsum 4GON http://www.ebi.ac.uk/pdbsum/4GON PDBsum 4GOO http://www.ebi.ac.uk/pdbsum/4GOO PDBsum 4RTJ http://www.ebi.ac.uk/pdbsum/4RTJ PDBsum 4RTK http://www.ebi.ac.uk/pdbsum/4RTK PDBsum 4RTL http://www.ebi.ac.uk/pdbsum/4RTL PDBsum 4RTM http://www.ebi.ac.uk/pdbsum/4RTM PDBsum 4RTN http://www.ebi.ac.uk/pdbsum/4RTN PDBsum 4RTO http://www.ebi.ac.uk/pdbsum/4RTO PDBsum 4RTP http://www.ebi.ac.uk/pdbsum/4RTP PDBsum 4RTQ http://www.ebi.ac.uk/pdbsum/4RTQ PDBsum 4RTR http://www.ebi.ac.uk/pdbsum/4RTR PDBsum 4RTS http://www.ebi.ac.uk/pdbsum/4RTS PRINTS PR00505 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00505 PROSITE PS00092 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00092 PSORT swissprot:DMA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DMA_ECOLI PSORT-B swissprot:DMA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DMA_ECOLI PSORT2 swissprot:DMA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DMA_ECOLI Pfam PF02086 http://pfam.xfam.org/family/PF02086 Phobius swissprot:DMA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DMA_ECOLI PhylomeDB P0AEE8 http://phylomedb.org/?seqid=P0AEE8 ProteinModelPortal P0AEE8 http://www.proteinmodelportal.org/query/uniprot/P0AEE8 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2549371 http://www.ncbi.nlm.nih.gov/pubmed/2549371 PubMed 6300769 http://www.ncbi.nlm.nih.gov/pubmed/6300769 PubMed 7603433 http://www.ncbi.nlm.nih.gov/pubmed/7603433 PubMed 8341592 http://www.ncbi.nlm.nih.gov/pubmed/8341592 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 REBASE 2396 http://rebase.neb.com/rebase/enz/2396.html RefSeq NP_417846 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417846 RefSeq WP_000742143 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000742143 SMR P0AEE8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AEE8 STRING 511145.b3387 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3387&targetmode=cogs STRING COG0338 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0338&targetmode=cogs SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 TIGRFAMs TIGR00571 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00571 UniProtKB DMA_ECOLI http://www.uniprot.org/uniprot/DMA_ECOLI UniProtKB-AC P0AEE8 http://www.uniprot.org/uniprot/P0AEE8 charge swissprot:DMA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DMA_ECOLI eggNOG COG0338 http://eggnogapi.embl.de/nog_data/html/tree/COG0338 eggNOG ENOG4105DFE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DFE epestfind swissprot:DMA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DMA_ECOLI garnier swissprot:DMA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DMA_ECOLI helixturnhelix swissprot:DMA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DMA_ECOLI hmoment swissprot:DMA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DMA_ECOLI iep swissprot:DMA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DMA_ECOLI inforesidue swissprot:DMA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DMA_ECOLI octanol swissprot:DMA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DMA_ECOLI pepcoil swissprot:DMA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DMA_ECOLI pepdigest swissprot:DMA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DMA_ECOLI pepinfo swissprot:DMA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DMA_ECOLI pepnet swissprot:DMA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DMA_ECOLI pepstats swissprot:DMA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DMA_ECOLI pepwheel swissprot:DMA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DMA_ECOLI pepwindow swissprot:DMA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DMA_ECOLI sigcleave swissprot:DMA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DMA_ECOLI ## Database ID URL or Descriptions # BioGrid 4259780 12 # EcoGene EG13550 yagK # IntAct P77657 9 # Organism YAGK_ECOLI Escherichia coli (strain K12) # PATRIC 32115677 VBIEscCol129921_0282 # PIR E64753 E64753 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAGK_ECOLI Uncharacterized protein YagK # RefSeq NP_414811 NC_000913.3 # RefSeq WP_000860996 NZ_LN832404.1 # SIMILARITY To E.coli YfjJ. {ECO 0000305}. # eggNOG ENOG4105JXR Bacteria # eggNOG ENOG4111RRQ LUCA BLAST swissprot:YAGK_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAGK_ECOLI BioCyc ECOL316407:JW0271-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0271-MONOMER BioCyc EcoCyc:G6148-MONOMER http://biocyc.org/getid?id=EcoCyc:G6148-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 EchoBASE EB3320 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3320 EcoGene EG13550 http://www.ecogene.org/geneInfo.php?eg_id=EG13550 EnsemblBacteria AAC73380 http://www.ensemblgenomes.org/id/AAC73380 EnsemblBacteria AAC73380 http://www.ensemblgenomes.org/id/AAC73380 EnsemblBacteria BAE76061 http://www.ensemblgenomes.org/id/BAE76061 EnsemblBacteria BAE76061 http://www.ensemblgenomes.org/id/BAE76061 EnsemblBacteria BAE76061 http://www.ensemblgenomes.org/id/BAE76061 EnsemblBacteria b0277 http://www.ensemblgenomes.org/id/b0277 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 945847 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945847 HOGENOM HOG000290900 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000290900&db=HOGENOM6 IntAct P77657 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77657* KEGG_Gene ecj:JW0271 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0271 KEGG_Gene eco:b0277 http://www.genome.jp/dbget-bin/www_bget?eco:b0277 OMA REFDWFG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=REFDWFG PSORT swissprot:YAGK_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAGK_ECOLI PSORT-B swissprot:YAGK_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAGK_ECOLI PSORT2 swissprot:YAGK_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAGK_ECOLI Phobius swissprot:YAGK_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAGK_ECOLI ProteinModelPortal P77657 http://www.proteinmodelportal.org/query/uniprot/P77657 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414811 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414811 RefSeq WP_000860996 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000860996 STRING 511145.b0277 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0277&targetmode=cogs UniProtKB YAGK_ECOLI http://www.uniprot.org/uniprot/YAGK_ECOLI UniProtKB-AC P77657 http://www.uniprot.org/uniprot/P77657 charge swissprot:YAGK_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAGK_ECOLI eggNOG ENOG4105JXR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105JXR eggNOG ENOG4111RRQ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111RRQ epestfind swissprot:YAGK_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAGK_ECOLI garnier swissprot:YAGK_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAGK_ECOLI helixturnhelix swissprot:YAGK_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAGK_ECOLI hmoment swissprot:YAGK_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAGK_ECOLI iep swissprot:YAGK_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAGK_ECOLI inforesidue swissprot:YAGK_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAGK_ECOLI octanol swissprot:YAGK_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAGK_ECOLI pepcoil swissprot:YAGK_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAGK_ECOLI pepdigest swissprot:YAGK_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAGK_ECOLI pepinfo swissprot:YAGK_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAGK_ECOLI pepnet swissprot:YAGK_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAGK_ECOLI pepstats swissprot:YAGK_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAGK_ECOLI pepwheel swissprot:YAGK_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAGK_ECOLI pepwindow swissprot:YAGK_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAGK_ECOLI sigcleave swissprot:YAGK_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAGK_ECOLI ## Database ID URL or Descriptions # BioGrid 4262189 12 # EcoGene EG11097 yajD # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003676 nucleic acid binding; IEA:InterPro. # GO_function GO:0004519 endonuclease activity; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0004518 nuclease activity # IntAct P0AAQ2 11 # InterPro IPR002711 HNH # InterPro IPR003615 HNH_nuc # Organism YAJD_ECOLI Escherichia coli (strain K12) # PATRIC 32115969 VBIEscCol129921_0426 # PIR B64770 B64770 # Pfam PF01844 HNH # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAJD_ECOLI Uncharacterized protein YajD # RefSeq NP_414944 NC_000913.3 # RefSeq WP_000974813 NZ_LN832404.1 # SIMILARITY Contains 1 HNH domain. {ECO 0000305}. # SMART SM00507 HNHc # eggNOG ENOG4105N1F Bacteria # eggNOG ENOG4111U2E LUCA BLAST swissprot:YAJD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAJD_ECOLI BioCyc ECOL316407:JW0400-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0400-MONOMER BioCyc EcoCyc:EG11097-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11097-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL X56175 http://www.ebi.ac.uk/ena/data/view/X56175 EchoBASE EB1089 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1089 EcoGene EG11097 http://www.ecogene.org/geneInfo.php?eg_id=EG11097 EnsemblBacteria AAC73513 http://www.ensemblgenomes.org/id/AAC73513 EnsemblBacteria AAC73513 http://www.ensemblgenomes.org/id/AAC73513 EnsemblBacteria BAE76190 http://www.ensemblgenomes.org/id/BAE76190 EnsemblBacteria BAE76190 http://www.ensemblgenomes.org/id/BAE76190 EnsemblBacteria BAE76190 http://www.ensemblgenomes.org/id/BAE76190 EnsemblBacteria b0410 http://www.ensemblgenomes.org/id/b0410 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003676 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003676 GO_function GO:0004519 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004519 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GeneID 945051 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945051 HOGENOM HOG000294005 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000294005&db=HOGENOM6 InParanoid P0AAQ2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAQ2 IntAct P0AAQ2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAQ2* InterPro IPR002711 http://www.ebi.ac.uk/interpro/entry/IPR002711 InterPro IPR003615 http://www.ebi.ac.uk/interpro/entry/IPR003615 KEGG_Gene ecj:JW0400 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0400 KEGG_Gene eco:b0410 http://www.genome.jp/dbget-bin/www_bget?eco:b0410 OMA DLKSMLN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DLKSMLN PSORT swissprot:YAJD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAJD_ECOLI PSORT-B swissprot:YAJD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAJD_ECOLI PSORT2 swissprot:YAJD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAJD_ECOLI Pfam PF01844 http://pfam.xfam.org/family/PF01844 Phobius swissprot:YAJD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAJD_ECOLI ProteinModelPortal P0AAQ2 http://www.proteinmodelportal.org/query/uniprot/P0AAQ2 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2170107 http://www.ncbi.nlm.nih.gov/pubmed/2170107 PubMed 2249673 http://www.ncbi.nlm.nih.gov/pubmed/2249673 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414944 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414944 RefSeq WP_000974813 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000974813 SMART SM00507 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00507 STRING 511145.b0410 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0410&targetmode=cogs UniProtKB YAJD_ECOLI http://www.uniprot.org/uniprot/YAJD_ECOLI UniProtKB-AC P0AAQ2 http://www.uniprot.org/uniprot/P0AAQ2 charge swissprot:YAJD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAJD_ECOLI eggNOG ENOG4105N1F http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105N1F eggNOG ENOG4111U2E http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111U2E epestfind swissprot:YAJD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAJD_ECOLI garnier swissprot:YAJD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAJD_ECOLI helixturnhelix swissprot:YAJD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAJD_ECOLI hmoment swissprot:YAJD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAJD_ECOLI iep swissprot:YAJD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAJD_ECOLI inforesidue swissprot:YAJD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAJD_ECOLI octanol swissprot:YAJD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAJD_ECOLI pepcoil swissprot:YAJD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAJD_ECOLI pepdigest swissprot:YAJD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAJD_ECOLI pepinfo swissprot:YAJD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAJD_ECOLI pepnet swissprot:YAJD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAJD_ECOLI pepstats swissprot:YAJD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAJD_ECOLI pepwheel swissprot:YAJD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAJD_ECOLI pepwindow swissprot:YAJD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAJD_ECOLI sigcleave swissprot:YAJD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAJD_ECOLI ## Database ID URL or Descriptions # BioGrid 4261596 11 # EcoGene EG11127 yciG # GO_process GO:0071978 bacterial-type flagellum-dependent swarming motility; IMP:EcoliWiki. # GOslim_process GO:0048870 cell motility # IntAct P21361 6 # InterPro IPR019626 Stress-induced_KGG_rpt # Organism YCIG_ECOLI Escherichia coli (strain K12) # PATRIC 32117778 VBIEscCol129921_1309 # PIR F64873 F64873 # Pfam PF10685 KGG; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCIG_ECOLI Uncharacterized protein YciG # RefSeq NP_415775 NC_000913.3 # RefSeq WP_000807651 NZ_LN832404.1 # SIMILARITY Belongs to the con-10 family. {ECO 0000305}. # eggNOG COG3729 LUCA BLAST swissprot:YCIG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCIG_ECOLI BioCyc ECOL316407:JW1251-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1251-MONOMER BioCyc EcoCyc:EG11127-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11127-MONOMER COG COG3729 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3729 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U23489 http://www.ebi.ac.uk/ena/data/view/U23489 EMBL U23490 http://www.ebi.ac.uk/ena/data/view/U23490 EMBL U23491 http://www.ebi.ac.uk/ena/data/view/U23491 EMBL U23492 http://www.ebi.ac.uk/ena/data/view/U23492 EMBL U23493 http://www.ebi.ac.uk/ena/data/view/U23493 EMBL U23495 http://www.ebi.ac.uk/ena/data/view/U23495 EMBL U23496 http://www.ebi.ac.uk/ena/data/view/U23496 EMBL U23497 http://www.ebi.ac.uk/ena/data/view/U23497 EMBL U25417 http://www.ebi.ac.uk/ena/data/view/U25417 EMBL U25418 http://www.ebi.ac.uk/ena/data/view/U25418 EMBL U25419 http://www.ebi.ac.uk/ena/data/view/U25419 EMBL U25420 http://www.ebi.ac.uk/ena/data/view/U25420 EMBL U25421 http://www.ebi.ac.uk/ena/data/view/U25421 EMBL U25422 http://www.ebi.ac.uk/ena/data/view/U25422 EMBL U25423 http://www.ebi.ac.uk/ena/data/view/U25423 EMBL U25425 http://www.ebi.ac.uk/ena/data/view/U25425 EMBL U25427 http://www.ebi.ac.uk/ena/data/view/U25427 EMBL U25429 http://www.ebi.ac.uk/ena/data/view/U25429 EMBL X13583 http://www.ebi.ac.uk/ena/data/view/X13583 EchoBASE EB1117 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1117 EcoGene EG11127 http://www.ecogene.org/geneInfo.php?eg_id=EG11127 EnsemblBacteria AAC74341 http://www.ensemblgenomes.org/id/AAC74341 EnsemblBacteria AAC74341 http://www.ensemblgenomes.org/id/AAC74341 EnsemblBacteria BAA14791 http://www.ensemblgenomes.org/id/BAA14791 EnsemblBacteria BAA14791 http://www.ensemblgenomes.org/id/BAA14791 EnsemblBacteria BAA14791 http://www.ensemblgenomes.org/id/BAA14791 EnsemblBacteria b1259 http://www.ensemblgenomes.org/id/b1259 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_process GO:0071978 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071978 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 GeneID 947489 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947489 HOGENOM HOG000201826 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000201826&db=HOGENOM6 InParanoid P21361 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P21361 IntAct P21361 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P21361* InterPro IPR019626 http://www.ebi.ac.uk/interpro/entry/IPR019626 KEGG_Gene ecj:JW1251 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1251 KEGG_Gene eco:b1259 http://www.genome.jp/dbget-bin/www_bget?eco:b1259 KEGG_Orthology KO:K06884 http://www.genome.jp/dbget-bin/www_bget?KO:K06884 OMA HINETMQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HINETMQ PSORT swissprot:YCIG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCIG_ECOLI PSORT-B swissprot:YCIG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCIG_ECOLI PSORT2 swissprot:YCIG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCIG_ECOLI Pfam PF10685 http://pfam.xfam.org/family/PF10685 Phobius swissprot:YCIG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCIG_ECOLI PhylomeDB P21361 http://phylomedb.org/?seqid=P21361 ProteinModelPortal P21361 http://www.proteinmodelportal.org/query/uniprot/P21361 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3058546 http://www.ncbi.nlm.nih.gov/pubmed/3058546 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415775 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415775 RefSeq WP_000807651 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000807651 STRING 511145.b1259 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1259&targetmode=cogs STRING COG3729 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3729&targetmode=cogs UniProtKB YCIG_ECOLI http://www.uniprot.org/uniprot/YCIG_ECOLI UniProtKB-AC P21361 http://www.uniprot.org/uniprot/P21361 charge swissprot:YCIG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCIG_ECOLI eggNOG COG3729 http://eggnogapi.embl.de/nog_data/html/tree/COG3729 epestfind swissprot:YCIG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCIG_ECOLI garnier swissprot:YCIG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCIG_ECOLI helixturnhelix swissprot:YCIG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCIG_ECOLI hmoment swissprot:YCIG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCIG_ECOLI iep swissprot:YCIG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCIG_ECOLI inforesidue swissprot:YCIG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCIG_ECOLI octanol swissprot:YCIG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCIG_ECOLI pepcoil swissprot:YCIG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCIG_ECOLI pepdigest swissprot:YCIG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCIG_ECOLI pepinfo swissprot:YCIG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCIG_ECOLI pepnet swissprot:YCIG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCIG_ECOLI pepstats swissprot:YCIG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCIG_ECOLI pepwheel swissprot:YCIG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCIG_ECOLI pepwindow swissprot:YCIG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCIG_ECOLI sigcleave swissprot:YCIG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCIG_ECOLI ## Database ID URL or Descriptions # CAUTION Product of a dubious gene prediction. {ECO 0000305}. # Organism Y309_ECOLI Escherichia coli (strain K12) # PIR E64757 E64757 # Proteomes UP000000625 Chromosome # RecName Y309_ECOLI Putative uncharacterized protein b0309 BLAST swissprot:Y309_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:Y309_ECOLI DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv OMA CKYPGII http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CKYPGII PSORT swissprot:Y309_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:Y309_ECOLI PSORT-B swissprot:Y309_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:Y309_ECOLI PSORT2 swissprot:Y309_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:Y309_ECOLI Phobius swissprot:Y309_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:Y309_ECOLI ProteinModelPortal P75688 http://www.proteinmodelportal.org/query/uniprot/P75688 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 UniProtKB Y309_ECOLI http://www.uniprot.org/uniprot/Y309_ECOLI UniProtKB-AC P75688 http://www.uniprot.org/uniprot/P75688 charge swissprot:Y309_ECOLI http://rest.g-language.org/emboss/charge/swissprot:Y309_ECOLI epestfind swissprot:Y309_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:Y309_ECOLI garnier swissprot:Y309_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:Y309_ECOLI helixturnhelix swissprot:Y309_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:Y309_ECOLI hmoment swissprot:Y309_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:Y309_ECOLI iep swissprot:Y309_ECOLI http://rest.g-language.org/emboss/iep/swissprot:Y309_ECOLI inforesidue swissprot:Y309_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:Y309_ECOLI octanol swissprot:Y309_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:Y309_ECOLI pepcoil swissprot:Y309_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:Y309_ECOLI pepdigest swissprot:Y309_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:Y309_ECOLI pepinfo swissprot:Y309_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:Y309_ECOLI pepnet swissprot:Y309_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:Y309_ECOLI pepstats swissprot:Y309_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:Y309_ECOLI pepwheel swissprot:Y309_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:Y309_ECOLI pepwindow swissprot:Y309_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:Y309_ECOLI sigcleave swissprot:Y309_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:Y309_ECOLI ## Database ID URL or Descriptions # BioGrid 4261498 8 # EcoGene EG13349 yagI # GO_function GO:0003677 DNA binding; IBA:GO_Central. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IBA:GO_Central. # GO_process GO:0006351 transcription, DNA-templated; ISS:EcoCyc. # GO_process GO:0044010 single-species biofilm formation; IMP:EcoCyc. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IBA:GO_Central. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # Gene3D 3.30.450.40 -; 1. # IntAct P77300 5 # InterPro IPR005471 Tscrpt_reg_IclR_N # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR014757 Tscrpt_reg_IclR_C # InterPro IPR029016 GAF_dom-like # Organism YAGI_ECOLI Escherichia coli (strain K12) # PATRIC 32115665 VBIEscCol129921_0276 # PIR H64752 H64752 # PROSITE PS51077 HTH_ICLR # PROSITE PS51078 ICLR_ED # Pfam PF01614 IclR # Pfam PF09339 HTH_IclR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YAGI_ECOLI Uncharacterized HTH-type transcriptional regulator YagI # RefSeq NP_414806 NC_000913.3 # RefSeq WP_001121657 NZ_LN832404.1 # SIMILARITY Contains 1 HTH iclR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00393}. # SIMILARITY Contains 1 iclR-ED (iclR effector binding) domain. {ECO:0000255|PROSITE-ProRule PRU00394}. # SMART SM00346 HTH_ICLR # SUPFAM SSF46785 SSF46785 # SUPFAM SSF55781 SSF55781 # eggNOG COG1414 LUCA # eggNOG ENOG4107HP6 Bacteria BLAST swissprot:YAGI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YAGI_ECOLI BioCyc ECOL316407:JW0265-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0265-MONOMER BioCyc EcoCyc:G6144-MONOMER http://biocyc.org/getid?id=EcoCyc:G6144-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 EchoBASE EB3133 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3133 EcoGene EG13349 http://www.ecogene.org/geneInfo.php?eg_id=EG13349 EnsemblBacteria AAC73375 http://www.ensemblgenomes.org/id/AAC73375 EnsemblBacteria AAC73375 http://www.ensemblgenomes.org/id/AAC73375 EnsemblBacteria BAE76056 http://www.ensemblgenomes.org/id/BAE76056 EnsemblBacteria BAE76056 http://www.ensemblgenomes.org/id/BAE76056 EnsemblBacteria BAE76056 http://www.ensemblgenomes.org/id/BAE76056 EnsemblBacteria b0272 http://www.ensemblgenomes.org/id/b0272 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0044010 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044010 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 3.30.450.40 http://www.cathdb.info/version/latest/superfamily/3.30.450.40 GeneID 945016 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945016 HOGENOM HOG000107041 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000107041&db=HOGENOM6 InParanoid P77300 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77300 IntAct P77300 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77300* InterPro IPR005471 http://www.ebi.ac.uk/interpro/entry/IPR005471 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR014757 http://www.ebi.ac.uk/interpro/entry/IPR014757 InterPro IPR029016 http://www.ebi.ac.uk/interpro/entry/IPR029016 KEGG_Gene ecj:JW0265 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0265 KEGG_Gene eco:b0272 http://www.genome.jp/dbget-bin/www_bget?eco:b0272 OMA LIAEPHL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LIAEPHL PROSITE PS51077 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51077 PROSITE PS51078 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51078 PSORT swissprot:YAGI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YAGI_ECOLI PSORT-B swissprot:YAGI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YAGI_ECOLI PSORT2 swissprot:YAGI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YAGI_ECOLI Pfam PF01614 http://pfam.xfam.org/family/PF01614 Pfam PF09339 http://pfam.xfam.org/family/PF09339 Phobius swissprot:YAGI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YAGI_ECOLI PhylomeDB P77300 http://phylomedb.org/?seqid=P77300 ProteinModelPortal P77300 http://www.proteinmodelportal.org/query/uniprot/P77300 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414806 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414806 RefSeq WP_001121657 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001121657 SMART SM00346 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00346 SMR P77300 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77300 STRING 511145.b0272 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0272&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SUPFAM SSF55781 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55781 UniProtKB YAGI_ECOLI http://www.uniprot.org/uniprot/YAGI_ECOLI UniProtKB-AC P77300 http://www.uniprot.org/uniprot/P77300 charge swissprot:YAGI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YAGI_ECOLI eggNOG COG1414 http://eggnogapi.embl.de/nog_data/html/tree/COG1414 eggNOG ENOG4107HP6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107HP6 epestfind swissprot:YAGI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YAGI_ECOLI garnier swissprot:YAGI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YAGI_ECOLI helixturnhelix swissprot:YAGI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YAGI_ECOLI hmoment swissprot:YAGI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YAGI_ECOLI iep swissprot:YAGI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YAGI_ECOLI inforesidue swissprot:YAGI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YAGI_ECOLI octanol swissprot:YAGI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YAGI_ECOLI pepcoil swissprot:YAGI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YAGI_ECOLI pepdigest swissprot:YAGI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YAGI_ECOLI pepinfo swissprot:YAGI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YAGI_ECOLI pepnet swissprot:YAGI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YAGI_ECOLI pepstats swissprot:YAGI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YAGI_ECOLI pepwheel swissprot:YAGI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YAGI_ECOLI pepwindow swissprot:YAGI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YAGI_ECOLI sigcleave swissprot:YAGI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YAGI_ECOLI ## Database ID URL or Descriptions # AltName MBHL_ECOLI Membrane-bound hydrogenase 1 large subunit # AltName MBHL_ECOLI NiFe hydrogenase # BRENDA 1.12.99 2026 # BioGrid 4260043 8 # CATALYTIC ACTIVITY MBHL_ECOLI H(2) + A = AH(2). # COFACTOR MBHL_ECOLI Name=Ni(2+); Xref=ChEBI CHEBI 49786; Evidence={ECO 0000250}; Note=Binds 1 nickel ion per subunit. {ECO 0000250}; # EcoGene EG10469 hyaB # FUNCTION MBHL_ECOLI This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD1 is believed to have a role in hydrogen cycling during fermentative growth. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_component GO:0044569 [Ni-Fe] hydrogenase complex; IDA:EcoCyc. # GO_function GO:0008901 ferredoxin hydrogenase activity; IEA:InterPro. # GO_function GO:0009055 electron carrier activity; IDA:EcoCyc. # GO_function GO:0016151 nickel cation binding; IDA:EcoCyc. # GO_function GO:0033748 hydrogenase (acceptor) activity; IEA:UniProtKB-EC. # GO_process GO:0006113 fermentation; IEP:EcoCyc. # GO_process GO:0009061 anaerobic respiration; IEP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006091 generation of precursor metabolites and energy # Gene3D 1.10.645.10 -; 1. # INTERACTION MBHL_ECOLI P19930 hyaD; NbExp=3; IntAct=EBI-851493, EBI-552940; # IntAct P0ACD8 8 # InterPro IPR001501 Ni-dep_hyd_lsu # InterPro IPR018194 Ni-dep_hyd_lsu_Ni_BS # InterPro IPR029014 NiFe_Hase-like # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00633 Nitrotoluene degradation # Organism MBHL_ECOLI Escherichia coli (strain K12) # PATRIC 32117167 VBIEscCol129921_1007 # PDB 3UQY X-ray; 1.47 A; L/M=1-582 # PDB 3USC X-ray; 2.00 A; L/M=1-582 # PDB 3USE X-ray; 1.67 A; L/M=1-582 # PDB 4GD3 X-ray; 3.30 A; J/K/L/M=1-582 # PDB 4UE3 X-ray; 1.40 A; L/M=1-582 # PDB 5A4F X-ray; 1.25 A; L/M=1-582 # PDB 5A4I X-ray; 1.23 A; L/M=1-582 # PDB 5A4M X-ray; 1.70 A; L/M=1-582 # PDB 5ADU X-ray; 1.10 A; L/M=1-582 # PIR C64838 HQECL # PROSITE PS00507 NI_HGENASE_L_1 # PROSITE PS00508 NI_HGENASE_L_2 # Pfam PF00374 NiFeSe_Hases # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MBHL_ECOLI Hydrogenase-1 large chain # RefSeq NP_415492 NC_000913.3 # RefSeq WP_000107384 NZ_LN832404.1 # SIMILARITY Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. {ECO 0000305}. # SUBCELLULAR LOCATION MBHL_ECOLI Cell membrane; Peripheral membrane protein. # SUBUNIT MBHL_ECOLI Heterodimer of a large and a small subunit. # SUPFAM SSF56762 SSF56762 # eggNOG COG0374 LUCA # eggNOG ENOG4105DPX Bacteria BLAST swissprot:MBHL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MBHL_ECOLI BioCyc ECOL316407:JW0955-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0955-MONOMER BioCyc EcoCyc:HYAB-MONOMER http://biocyc.org/getid?id=EcoCyc:HYAB-MONOMER BioCyc MetaCyc:HYAB-MONOMER http://biocyc.org/getid?id=MetaCyc:HYAB-MONOMER COG COG0374 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0374 DIP DIP-36180N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36180N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.12.99.6 http://www.genome.jp/dbget-bin/www_bget?EC:1.12.99.6 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M34825 http://www.ebi.ac.uk/ena/data/view/M34825 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.12.99.6 http://enzyme.expasy.org/EC/1.12.99.6 EchoBASE EB0464 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0464 EcoGene EG10469 http://www.ecogene.org/geneInfo.php?eg_id=EG10469 EnsemblBacteria AAC74058 http://www.ensemblgenomes.org/id/AAC74058 EnsemblBacteria AAC74058 http://www.ensemblgenomes.org/id/AAC74058 EnsemblBacteria BAA35738 http://www.ensemblgenomes.org/id/BAA35738 EnsemblBacteria BAA35738 http://www.ensemblgenomes.org/id/BAA35738 EnsemblBacteria BAA35738 http://www.ensemblgenomes.org/id/BAA35738 EnsemblBacteria b0973 http://www.ensemblgenomes.org/id/b0973 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_component GO:0044569 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044569 GO_function GO:0008901 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008901 GO_function GO:0009055 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055 GO_function GO:0016151 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016151 GO_function GO:0033748 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033748 GO_process GO:0006113 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006113 GO_process GO:0009061 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009061 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006091 Gene3D 1.10.645.10 http://www.cathdb.info/version/latest/superfamily/1.10.645.10 GeneID 945580 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945580 HOGENOM HOG000278799 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278799&db=HOGENOM6 InParanoid P0ACD8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ACD8 IntAct P0ACD8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ACD8* IntEnz 1.12.99.6 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.12.99.6 InterPro IPR001501 http://www.ebi.ac.uk/interpro/entry/IPR001501 InterPro IPR018194 http://www.ebi.ac.uk/interpro/entry/IPR018194 InterPro IPR029014 http://www.ebi.ac.uk/interpro/entry/IPR029014 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0955 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0955 KEGG_Gene eco:b0973 http://www.genome.jp/dbget-bin/www_bget?eco:b0973 KEGG_Orthology KO:K06281 http://www.genome.jp/dbget-bin/www_bget?KO:K06281 KEGG_Pathway ko00633 http://www.genome.jp/kegg-bin/show_pathway?ko00633 KEGG_Reaction rn:R08034 http://www.genome.jp/dbget-bin/www_bget?rn:R08034 OMA EEVSHSW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EEVSHSW PDB 3UQY http://www.ebi.ac.uk/pdbe-srv/view/entry/3UQY PDB 3USC http://www.ebi.ac.uk/pdbe-srv/view/entry/3USC PDB 3USE http://www.ebi.ac.uk/pdbe-srv/view/entry/3USE PDB 4GD3 http://www.ebi.ac.uk/pdbe-srv/view/entry/4GD3 PDB 4UE3 http://www.ebi.ac.uk/pdbe-srv/view/entry/4UE3 PDB 5A4F http://www.ebi.ac.uk/pdbe-srv/view/entry/5A4F PDB 5A4I http://www.ebi.ac.uk/pdbe-srv/view/entry/5A4I PDB 5A4M http://www.ebi.ac.uk/pdbe-srv/view/entry/5A4M PDB 5ADU http://www.ebi.ac.uk/pdbe-srv/view/entry/5ADU PDBsum 3UQY http://www.ebi.ac.uk/pdbsum/3UQY PDBsum 3USC http://www.ebi.ac.uk/pdbsum/3USC PDBsum 3USE http://www.ebi.ac.uk/pdbsum/3USE PDBsum 4GD3 http://www.ebi.ac.uk/pdbsum/4GD3 PDBsum 4UE3 http://www.ebi.ac.uk/pdbsum/4UE3 PDBsum 5A4F http://www.ebi.ac.uk/pdbsum/5A4F PDBsum 5A4I http://www.ebi.ac.uk/pdbsum/5A4I PDBsum 5A4M http://www.ebi.ac.uk/pdbsum/5A4M PDBsum 5ADU http://www.ebi.ac.uk/pdbsum/5ADU PROSITE PS00507 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00507 PROSITE PS00508 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00508 PSORT swissprot:MBHL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MBHL_ECOLI PSORT-B swissprot:MBHL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MBHL_ECOLI PSORT2 swissprot:MBHL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MBHL_ECOLI Pfam PF00374 http://pfam.xfam.org/family/PF00374 Phobius swissprot:MBHL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MBHL_ECOLI PhylomeDB P0ACD8 http://phylomedb.org/?seqid=P0ACD8 ProteinModelPortal P0ACD8 http://www.proteinmodelportal.org/query/uniprot/P0ACD8 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2180913 http://www.ncbi.nlm.nih.gov/pubmed/2180913 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415492 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415492 RefSeq WP_000107384 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000107384 SMR P0ACD8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ACD8 STRING 511145.b0973 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0973&targetmode=cogs STRING COG0374 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0374&targetmode=cogs SUPFAM SSF56762 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56762 UniProtKB MBHL_ECOLI http://www.uniprot.org/uniprot/MBHL_ECOLI UniProtKB-AC P0ACD8 http://www.uniprot.org/uniprot/P0ACD8 charge swissprot:MBHL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MBHL_ECOLI eggNOG COG0374 http://eggnogapi.embl.de/nog_data/html/tree/COG0374 eggNOG ENOG4105DPX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DPX epestfind swissprot:MBHL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MBHL_ECOLI garnier swissprot:MBHL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MBHL_ECOLI helixturnhelix swissprot:MBHL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MBHL_ECOLI hmoment swissprot:MBHL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MBHL_ECOLI iep swissprot:MBHL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MBHL_ECOLI inforesidue swissprot:MBHL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MBHL_ECOLI octanol swissprot:MBHL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MBHL_ECOLI pepcoil swissprot:MBHL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MBHL_ECOLI pepdigest swissprot:MBHL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MBHL_ECOLI pepinfo swissprot:MBHL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MBHL_ECOLI pepnet swissprot:MBHL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MBHL_ECOLI pepstats swissprot:MBHL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MBHL_ECOLI pepwheel swissprot:MBHL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MBHL_ECOLI pepwindow swissprot:MBHL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MBHL_ECOLI sigcleave swissprot:MBHL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MBHL_ECOLI ## Database ID URL or Descriptions # BioGrid 4261061 21 # EcoGene EG11891 yeeA # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006810 transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006810 transport # InterPro IPR006726 PHBA_efflux_AaeB/fusaric-R # Organism YEEA_ECOLI Escherichia coli (strain K12) # PATRIC 32119351 VBIEscCol129921_2085 # PIR G64965 G64965 # Pfam PF04632 FUSC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEEA_ECOLI Inner membrane protein YeeA # RefSeq NP_416512 NC_000913.3 # RefSeq WP_001200891 NZ_LN832404.1 # SUBCELLULAR LOCATION YEEA_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.85.7 the aromatic acid exporter (arae) family # eggNOG COG1289 LUCA # eggNOG ENOG4105DR8 Bacteria BLAST swissprot:YEEA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEEA_ECOLI BioCyc ECOL316407:JW1990-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1990-MONOMER BioCyc EcoCyc:EG11891-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11891-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00009 http://www.ebi.ac.uk/ena/data/view/U00009 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1837 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1837 EcoGene EG11891 http://www.ecogene.org/geneInfo.php?eg_id=EG11891 EnsemblBacteria AAC75069 http://www.ensemblgenomes.org/id/AAC75069 EnsemblBacteria AAC75069 http://www.ensemblgenomes.org/id/AAC75069 EnsemblBacteria BAA15829 http://www.ensemblgenomes.org/id/BAA15829 EnsemblBacteria BAA15829 http://www.ensemblgenomes.org/id/BAA15829 EnsemblBacteria BAA15829 http://www.ensemblgenomes.org/id/BAA15829 EnsemblBacteria b2008 http://www.ensemblgenomes.org/id/b2008 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 946545 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946545 HOGENOM HOG000280944 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000280944&db=HOGENOM6 InterPro IPR006726 http://www.ebi.ac.uk/interpro/entry/IPR006726 KEGG_Gene ecj:JW1990 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1990 KEGG_Gene eco:b2008 http://www.genome.jp/dbget-bin/www_bget?eco:b2008 OMA TLGKRPY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TLGKRPY PSORT swissprot:YEEA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEEA_ECOLI PSORT-B swissprot:YEEA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEEA_ECOLI PSORT2 swissprot:YEEA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEEA_ECOLI Pfam PF04632 http://pfam.xfam.org/family/PF04632 Phobius swissprot:YEEA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEEA_ECOLI ProteinModelPortal P33011 http://www.proteinmodelportal.org/query/uniprot/P33011 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416512 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416512 RefSeq WP_001200891 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001200891 STRING 511145.b2008 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2008&targetmode=cogs TCDB 2.A.85.7 http://www.tcdb.org/search/result.php?tc=2.A.85.7 UniProtKB YEEA_ECOLI http://www.uniprot.org/uniprot/YEEA_ECOLI UniProtKB-AC P33011 http://www.uniprot.org/uniprot/P33011 charge swissprot:YEEA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEEA_ECOLI eggNOG COG1289 http://eggnogapi.embl.de/nog_data/html/tree/COG1289 eggNOG ENOG4105DR8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DR8 epestfind swissprot:YEEA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEEA_ECOLI garnier swissprot:YEEA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEEA_ECOLI helixturnhelix swissprot:YEEA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEEA_ECOLI hmoment swissprot:YEEA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEEA_ECOLI iep swissprot:YEEA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEEA_ECOLI inforesidue swissprot:YEEA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEEA_ECOLI octanol swissprot:YEEA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEEA_ECOLI pepcoil swissprot:YEEA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEEA_ECOLI pepdigest swissprot:YEEA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEEA_ECOLI pepinfo swissprot:YEEA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEEA_ECOLI pepnet swissprot:YEEA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEEA_ECOLI pepstats swissprot:YEEA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEEA_ECOLI pepwheel swissprot:YEEA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEEA_ECOLI pepwindow swissprot:YEEA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEEA_ECOLI sigcleave swissprot:YEEA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEEA_ECOLI ## Database ID URL or Descriptions # CAUTION Could be the product of a pseudogene. In strain K12 the phnE gene has an 8-bp insertion, absent from the strain B gene, which causes a frameshift mutation. {ECO 0000305}. # CDD cd06261 TM_PBP2 # EcoGene EG11283 phnE # FUNCTION PHNE_ECOLI Part of the binding-protein-dependent transport system for phosphonates; probably responsible for the translocation of the substrate across the membrane. # GO_component GO:0005887 integral component of plasma membrane; IEA:InterPro. # GO_function GO:0015604 organic phosphonate transmembrane transporter activity; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0022857 transmembrane transporter activity # Gene3D 1.10.3720.10 -; 1. # InterPro IPR000515 MetI-like # InterPro IPR005769 PhnE/PtxC # MISCELLANEOUS PHNE_ECOLI The sequence shown is that of strain B. # Organism PHNE_ECOLI Escherichia coli (strain K12) # PIR F35718 F35718 # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PHNE_ECOLI Putative phosphonates transport system permease protein PhnE # SEQUENCE CAUTION PHNE_ECOLI Sequence=AAA24341.1; Type=Erroneous initiation; Evidence={ECO 0000305}; Sequence=AAA97002.1; Type=Frameshift; Positions=155; Evidence={ECO 0000305}; Sequence=AAA97003.1; Type=Frameshift; Positions=155; Evidence={ECO 0000305}; Sequence=BAA14264.1; Type=Frameshift; Positions=155; Evidence={ECO 0000305}; Sequence=BAA14265.1; Type=Frameshift; Positions=155; Evidence={ECO 0000305}; Sequence=BAE78106.1; Type=Frameshift; Positions=155; Evidence={ECO 0000305}; Sequence=U00096; Type=Frameshift; Positions=155; Evidence={ECO 0000305}; # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION PHNE_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00441, ECO 0000269|PubMed 15919996}. # SUBUNIT The complex is composed of two ATP-binding proteins (PhnC), two transmembrane proteins (PhnE) and a solute-binding protein (PhnD). {ECO 0000305}. # SUPFAM SSF161098 SSF161098 # TCDB 3.A.1.9 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR01097 PhnE BLAST swissprot:PHNE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PHNE_ECOLI BioCyc ECOL316407:JW4065-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4065-MONOMER BioCyc EcoCyc:G7822-MONOMER http://biocyc.org/getid?id=EcoCyc:G7822-MONOMER BioCyc EcoCyc:PHNE-MONOMER http://biocyc.org/getid?id=EcoCyc:PHNE-MONOMER BioCyc MetaCyc:PHNE-MONOMER http://biocyc.org/getid?id=MetaCyc:PHNE-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D90227 http://www.ebi.ac.uk/ena/data/view/D90227 EMBL D90227 http://www.ebi.ac.uk/ena/data/view/D90227 EMBL J05260 http://www.ebi.ac.uk/ena/data/view/J05260 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB1260 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1260 EcoGene EG11283 http://www.ecogene.org/geneInfo.php?eg_id=EG11283 EnsemblBacteria BAE78106 http://www.ensemblgenomes.org/id/BAE78106 EnsemblBacteria BAE78106 http://www.ensemblgenomes.org/id/BAE78106 EnsemblBacteria BAE78106 http://www.ensemblgenomes.org/id/BAE78106 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015604 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015604 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 HOGENOM HOG000095580 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000095580&db=HOGENOM6 InParanoid P16683 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P16683 InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 InterPro IPR005769 http://www.ebi.ac.uk/interpro/entry/IPR005769 OMA MALFIHT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MALFIHT PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:PHNE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PHNE_ECOLI PSORT-B swissprot:PHNE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PHNE_ECOLI PSORT2 swissprot:PHNE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PHNE_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Phobius swissprot:PHNE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PHNE_ECOLI PhylomeDB P16683 http://phylomedb.org/?seqid=P16683 ProteinModelPortal P16683 http://www.proteinmodelportal.org/query/uniprot/P16683 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1840580 http://www.ncbi.nlm.nih.gov/pubmed/1840580 PubMed 2155230 http://www.ncbi.nlm.nih.gov/pubmed/2155230 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SMR P16683 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P16683 SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.9 http://www.tcdb.org/search/result.php?tc=3.A.1.9 TIGRFAMs TIGR01097 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01097 UniProtKB PHNE_ECOLI http://www.uniprot.org/uniprot/PHNE_ECOLI UniProtKB-AC P16683 http://www.uniprot.org/uniprot/P16683 charge swissprot:PHNE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PHNE_ECOLI epestfind swissprot:PHNE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PHNE_ECOLI garnier swissprot:PHNE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PHNE_ECOLI helixturnhelix swissprot:PHNE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PHNE_ECOLI hmoment swissprot:PHNE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PHNE_ECOLI iep swissprot:PHNE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PHNE_ECOLI inforesidue swissprot:PHNE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PHNE_ECOLI octanol swissprot:PHNE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PHNE_ECOLI pepcoil swissprot:PHNE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PHNE_ECOLI pepdigest swissprot:PHNE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PHNE_ECOLI pepinfo swissprot:PHNE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PHNE_ECOLI pepnet swissprot:PHNE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PHNE_ECOLI pepstats swissprot:PHNE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PHNE_ECOLI pepwheel swissprot:PHNE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PHNE_ECOLI pepwindow swissprot:PHNE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PHNE_ECOLI sigcleave swissprot:PHNE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PHNE_ECOLI ## Database ID URL or Descriptions # BioGrid 4262979 9 # CAUTION This protein is probably not frameshifted under normal conditions; however as suggested for V.cholerae acfD in strain Ogawa 395 it might be translated under certain special conditions. {ECO 0000305}. # EcoGene EG12994 yghJ # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GOslim_component GO:0005886 plasma membrane # InterPro IPR025385 DUF4092 # InterPro IPR031161 Peptidase_M60_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko05111 Vibrio cholerae pathogenic cycle # Organism ACFD_ECOLI Escherichia coli (strain K12) # PATRIC 32121362 VBIEscCol129921_3068 # PROSITE PS51257 PROKAR_LIPOPROTEIN # PROSITE PS51723 PEPTIDASE_M60 # Pfam PF13322 DUF4092 # Pfam PF13402 Peptidase_M60 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ACFD_ECOLI Putative lipoprotein AcfD homolog # RefSeq WP_001034469 NZ_LN832404.1 # RefSeq YP_026189 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA69140.1; Type=Frameshift; Positions=672; Evidence={ECO:0000305}; Sequence=AAA69141.1; Type=Frameshift; Positions=672; Evidence={ECO 0000305}; # SIMILARITY Contains 1 peptidase M60 domain. {ECO:0000255|PROSITE- ProRule PRU01060}. # SIMILARITY To V.cholerae AcfD (VC_0845). {ECO 0000305}. # SMART SM01276 M60-like # SUBCELLULAR LOCATION ACFD_ECOLI Cell membrane {ECO 0000255|PROSITE- ProRule PRU00303}; Lipid-anchor {ECO 0000255|PROSITE- ProRule PRU00303}. # eggNOG ENOG4105F88 Bacteria # eggNOG ENOG410XS21 LUCA BLAST swissprot:ACFD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ACFD_ECOLI BioCyc EcoCyc:G7541-MONOMER http://biocyc.org/getid?id=EcoCyc:G7541-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AF426313 http://www.ebi.ac.uk/ena/data/view/AF426313 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 EcoGene EG12994 http://www.ecogene.org/geneInfo.php?eg_id=EG12994 EnsemblBacteria AAT48156 http://www.ensemblgenomes.org/id/AAT48156 EnsemblBacteria AAT48156 http://www.ensemblgenomes.org/id/AAT48156 EnsemblBacteria BAE77034 http://www.ensemblgenomes.org/id/BAE77034 EnsemblBacteria BAE77034 http://www.ensemblgenomes.org/id/BAE77034 EnsemblBacteria BAE77034 http://www.ensemblgenomes.org/id/BAE77034 EnsemblBacteria b4466 http://www.ensemblgenomes.org/id/b4466 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 2847716 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2847716 InterPro IPR025385 http://www.ebi.ac.uk/interpro/entry/IPR025385 InterPro IPR031161 http://www.ebi.ac.uk/interpro/entry/IPR031161 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW5925 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5925 KEGG_Gene eco:b4466 http://www.genome.jp/dbget-bin/www_bget?eco:b4466 KEGG_Orthology KO:K10939 http://www.genome.jp/dbget-bin/www_bget?KO:K10939 KEGG_Pathway ko05111 http://www.genome.jp/kegg-bin/show_pathway?ko05111 OMA VMGNARY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VMGNARY PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PROSITE PS51723 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51723 PSORT swissprot:ACFD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ACFD_ECOLI PSORT-B swissprot:ACFD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ACFD_ECOLI PSORT2 swissprot:ACFD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ACFD_ECOLI Pfam PF13322 http://pfam.xfam.org/family/PF13322 Pfam PF13402 http://pfam.xfam.org/family/PF13402 Phobius swissprot:ACFD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ACFD_ECOLI ProteinModelPortal P0CK95 http://www.proteinmodelportal.org/query/uniprot/P0CK95 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001034469 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001034469 RefSeq YP_026189 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026189 SMART SM01276 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01276 STRING 511145.b4466 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4466&targetmode=cogs UniProtKB ACFD_ECOLI http://www.uniprot.org/uniprot/ACFD_ECOLI UniProtKB-AC P0CK95 http://www.uniprot.org/uniprot/P0CK95 charge swissprot:ACFD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ACFD_ECOLI eggNOG ENOG4105F88 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F88 eggNOG ENOG410XS21 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XS21 epestfind swissprot:ACFD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ACFD_ECOLI garnier swissprot:ACFD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ACFD_ECOLI helixturnhelix swissprot:ACFD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ACFD_ECOLI hmoment swissprot:ACFD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ACFD_ECOLI iep swissprot:ACFD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ACFD_ECOLI inforesidue swissprot:ACFD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ACFD_ECOLI octanol swissprot:ACFD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ACFD_ECOLI pepcoil swissprot:ACFD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ACFD_ECOLI pepdigest swissprot:ACFD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ACFD_ECOLI pepinfo swissprot:ACFD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ACFD_ECOLI pepnet swissprot:ACFD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ACFD_ECOLI pepstats swissprot:ACFD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ACFD_ECOLI pepwheel swissprot:ACFD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ACFD_ECOLI pepwindow swissprot:ACFD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ACFD_ECOLI sigcleave swissprot:ACFD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ACFD_ECOLI ## Database ID URL or Descriptions # AltName GALM_ECOLI Galactose mutarotase # AltName GALM_ECOLI Type-1 mutarotase # BRENDA 5.1.3.B1 2026 # BioGrid 4261710 6 # CATALYTIC ACTIVITY Alpha-D-glucose = beta-D-glucose. {ECO:0000255|PROSITE-ProRule PRU10126}. # EcoGene EG11698 galM # FUNCTION GALM_ECOLI Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose. # GO_component GO:0005737 cytoplasm; IDA:EcoCyc. # GO_function GO:0004034 aldose 1-epimerase activity; IDA:EcoCyc. # GO_function GO:0030246 carbohydrate binding; IEA:InterPro. # GO_process GO:0006006 glucose metabolic process; IBA:GO_Central. # GO_process GO:0033499 galactose catabolic process via UDP-galactose; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 2.70.98.10 -; 1. # IntAct P0A9C3 4 # InterPro IPR008183 Aldose_1/G6P_1-epimerase # InterPro IPR011013 Gal_mutarotase_SF_dom # InterPro IPR013458 Ald_epimerase_bac # InterPro IPR014718 GH-type_carb-bd # InterPro IPR015443 Aldose_1-epimerase # InterPro IPR018052 Ald1_epimerase_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00010 Glycolysis / Gluconeogenesis # Organism GALM_ECOLI Escherichia coli (strain K12) # PATHWAY GALM_ECOLI Carbohydrate metabolism; hexose metabolism. # PATRIC 32116713 VBIEscCol129921_0782 # PIR D64811 D64811 # PIRSF PIRSF005096 GALM # PROSITE PS00545 ALDOSE_1_EPIMERASE # Pfam PF01263 Aldose_epim # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GALM_ECOLI Aldose 1-epimerase # RefSeq NP_415277 NC_000913.3 # RefSeq WP_000931389 NZ_LN832404.1 # SIMILARITY Belongs to the aldose epimerase family. {ECO 0000305}. # SUBCELLULAR LOCATION GALM_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF74650 SSF74650 # TIGRFAMs TIGR02636 galM_Leloir # eggNOG COG2017 LUCA # eggNOG ENOG4105ENN Bacteria BLAST swissprot:GALM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GALM_ECOLI BioCyc ECOL316407:JW0739-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0739-MONOMER BioCyc EcoCyc:ALDOSE1EPIM-MONOMER http://biocyc.org/getid?id=EcoCyc:ALDOSE1EPIM-MONOMER BioCyc MetaCyc:ALDOSE1EPIM-MONOMER http://biocyc.org/getid?id=MetaCyc:ALDOSE1EPIM-MONOMER COG COG2017 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2017 DIP DIP-35901N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35901N DOI 10.1006/jmbi.1994.1728 http://dx.doi.org/10.1006/jmbi.1994.1728 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.1.3.3 http://www.genome.jp/dbget-bin/www_bget?EC:5.1.3.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U13636 http://www.ebi.ac.uk/ena/data/view/U13636 ENZYME 5.1.3.3 http://enzyme.expasy.org/EC/5.1.3.3 EchoBASE EB1649 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1649 EcoGene EG11698 http://www.ecogene.org/geneInfo.php?eg_id=EG11698 EnsemblBacteria AAC73843 http://www.ensemblgenomes.org/id/AAC73843 EnsemblBacteria AAC73843 http://www.ensemblgenomes.org/id/AAC73843 EnsemblBacteria BAA35418 http://www.ensemblgenomes.org/id/BAA35418 EnsemblBacteria BAA35418 http://www.ensemblgenomes.org/id/BAA35418 EnsemblBacteria BAA35418 http://www.ensemblgenomes.org/id/BAA35418 EnsemblBacteria b0756 http://www.ensemblgenomes.org/id/b0756 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0004034 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004034 GO_function GO:0030246 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030246 GO_process GO:0006006 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006006 GO_process GO:0033499 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033499 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 2.70.98.10 http://www.cathdb.info/version/latest/superfamily/2.70.98.10 GeneID 944943 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944943 HOGENOM HOG000072798 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000072798&db=HOGENOM6 InParanoid P0A9C3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A9C3 IntAct P0A9C3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A9C3* IntEnz 5.1.3.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.1.3.3 InterPro IPR008183 http://www.ebi.ac.uk/interpro/entry/IPR008183 InterPro IPR011013 http://www.ebi.ac.uk/interpro/entry/IPR011013 InterPro IPR013458 http://www.ebi.ac.uk/interpro/entry/IPR013458 InterPro IPR014718 http://www.ebi.ac.uk/interpro/entry/IPR014718 InterPro IPR015443 http://www.ebi.ac.uk/interpro/entry/IPR015443 InterPro IPR018052 http://www.ebi.ac.uk/interpro/entry/IPR018052 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0739 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0739 KEGG_Gene eco:b0756 http://www.genome.jp/dbget-bin/www_bget?eco:b0756 KEGG_Orthology KO:K01785 http://www.genome.jp/dbget-bin/www_bget?KO:K01785 KEGG_Pathway ko00010 http://www.genome.jp/kegg-bin/show_pathway?ko00010 KEGG_Reaction rn:R01602 http://www.genome.jp/dbget-bin/www_bget?rn:R01602 MINT MINT-1249454 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1249454 OMA SPNHPDW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SPNHPDW PROSITE PS00545 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00545 PSORT swissprot:GALM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GALM_ECOLI PSORT-B swissprot:GALM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GALM_ECOLI PSORT2 swissprot:GALM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GALM_ECOLI Pfam PF01263 http://pfam.xfam.org/family/PF01263 Phobius swissprot:GALM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GALM_ECOLI PhylomeDB P0A9C3 http://phylomedb.org/?seqid=P0A9C3 ProteinModelPortal P0A9C3 http://www.proteinmodelportal.org/query/uniprot/P0A9C3 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7966338 http://www.ncbi.nlm.nih.gov/pubmed/7966338 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415277 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415277 RefSeq WP_000931389 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000931389 SMR P0A9C3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A9C3 STRING 511145.b0756 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0756&targetmode=cogs STRING COG2017 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2017&targetmode=cogs SUPFAM SSF74650 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF74650 SWISS-2DPAGE P0A9C3 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0A9C3 TIGRFAMs TIGR02636 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02636 UniProtKB GALM_ECOLI http://www.uniprot.org/uniprot/GALM_ECOLI UniProtKB-AC P0A9C3 http://www.uniprot.org/uniprot/P0A9C3 charge swissprot:GALM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GALM_ECOLI eggNOG COG2017 http://eggnogapi.embl.de/nog_data/html/tree/COG2017 eggNOG ENOG4105ENN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ENN epestfind swissprot:GALM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GALM_ECOLI garnier swissprot:GALM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GALM_ECOLI helixturnhelix swissprot:GALM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GALM_ECOLI hmoment swissprot:GALM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GALM_ECOLI iep swissprot:GALM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GALM_ECOLI inforesidue swissprot:GALM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GALM_ECOLI octanol swissprot:GALM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GALM_ECOLI pepcoil swissprot:GALM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GALM_ECOLI pepdigest swissprot:GALM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GALM_ECOLI pepinfo swissprot:GALM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GALM_ECOLI pepnet swissprot:GALM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GALM_ECOLI pepstats swissprot:GALM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GALM_ECOLI pepwheel swissprot:GALM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GALM_ECOLI pepwindow swissprot:GALM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GALM_ECOLI sigcleave swissprot:GALM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GALM_ECOLI ## Database ID URL or Descriptions # BRENDA 2.7.7.75 2026 # BioGrid 4261931 11 # CATALYTIC ACTIVITY MOG_ECOLI ATP + molybdopterin = diphosphate + adenylyl- molybdopterin. # CDD cd00886 MogA_MoaB # EcoGene EG11511 mog # FUNCTION MOG_ECOLI Catalyzes the adenylation of molybdopterin as part of the biosynthesis of the molybdenum-cofactor. {ECO 0000269|PubMed 15632135}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0042802 identical protein binding; IPI:EcoCyc. # GO_function GO:0061598 molybdopterin adenylyltransferase activity; IDA:EcoCyc. # GO_process GO:0006777 Mo-molybdopterin cofactor biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0032324 molybdopterin cofactor biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.980.10 -; 1. # IntAct P0AF03 9 # InterPro IPR001453 MoaB/Mog_dom # InterPro IPR008284 MoCF_biosynth_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko04122 Sulfur relay system # Organism MOG_ECOLI Escherichia coli (strain K12) # PATHWAY MOG_ECOLI Cofactor biosynthesis; molybdopterin biosynthesis. # PATRIC 32115113 VBIEscCol129921_0008 # PDB 1DI6 X-ray; 1.45 A; A=3-195 # PDB 1DI7 X-ray; 1.60 A; A=3-195 # PIR B56688 B56688 # PROSITE PS01078 MOCF_BIOSYNTHESIS_1 # Pfam PF00994 MoCF_biosynth # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MOG_ECOLI Molybdopterin adenylyltransferase # RefSeq NP_414550 NC_000913.3 # RefSeq WP_001295414 NZ_LN832404.1 # SIMILARITY Belongs to the MoaB/Mog family. {ECO 0000305}. # SMART SM00852 MoCF_biosynth # SUBUNIT MOG_ECOLI Homotrimer. Interacts with MoeA and MobB in vivo. {ECO 0000269|PubMed 10636880, ECO 0000269|PubMed 12372836}. # SUPFAM SSF53218 SSF53218 # TIGRFAMs TIGR00177 molyb_syn # eggNOG COG0521 LUCA # eggNOG ENOG4108RIR Bacteria BLAST swissprot:MOG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MOG_ECOLI BioCyc ECOL316407:JW0008-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0008-MONOMER BioCyc EcoCyc:EG11511-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11511-MONOMER BioCyc MetaCyc:EG11511-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11511-MONOMER COG COG0521 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0521 DIP DIP-35784N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35784N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.275.3.1814 http://dx.doi.org/10.1074/jbc.275.3.1814 DOI 10.1074/jbc.M205806200 http://dx.doi.org/10.1074/jbc.M205806200 DOI 10.1074/jbc.M413783200 http://dx.doi.org/10.1074/jbc.M413783200 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.7.75 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.75 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X67700 http://www.ebi.ac.uk/ena/data/view/X67700 ENZYME 2.7.7.75 http://enzyme.expasy.org/EC/2.7.7.75 EchoBASE EB1473 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1473 EcoGene EG11511 http://www.ecogene.org/geneInfo.php?eg_id=EG11511 EnsemblBacteria AAC73120 http://www.ensemblgenomes.org/id/AAC73120 EnsemblBacteria AAC73120 http://www.ensemblgenomes.org/id/AAC73120 EnsemblBacteria BAB96587 http://www.ensemblgenomes.org/id/BAB96587 EnsemblBacteria BAB96587 http://www.ensemblgenomes.org/id/BAB96587 EnsemblBacteria BAB96587 http://www.ensemblgenomes.org/id/BAB96587 EnsemblBacteria b0009 http://www.ensemblgenomes.org/id/b0009 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0061598 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061598 GO_process GO:0006777 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006777 GO_process GO:0032324 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032324 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.980.10 http://www.cathdb.info/version/latest/superfamily/3.40.980.10 GeneID 944760 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944760 HOGENOM HOG000281103 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000281103&db=HOGENOM6 InParanoid P0AF03 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AF03 IntAct P0AF03 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AF03* IntEnz 2.7.7.75 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.75 InterPro IPR001453 http://www.ebi.ac.uk/interpro/entry/IPR001453 InterPro IPR008284 http://www.ebi.ac.uk/interpro/entry/IPR008284 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0008 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0008 KEGG_Gene eco:b0009 http://www.genome.jp/dbget-bin/www_bget?eco:b0009 KEGG_Orthology KO:K03831 http://www.genome.jp/dbget-bin/www_bget?KO:K03831 KEGG_Pathway ko04122 http://www.genome.jp/kegg-bin/show_pathway?ko04122 KEGG_Reaction rn:R09726 http://www.genome.jp/dbget-bin/www_bget?rn:R09726 MINT MINT-1238245 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1238245 OMA YQDEGIP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YQDEGIP PDB 1DI6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1DI6 PDB 1DI7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1DI7 PDBsum 1DI6 http://www.ebi.ac.uk/pdbsum/1DI6 PDBsum 1DI7 http://www.ebi.ac.uk/pdbsum/1DI7 PROSITE PS01078 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01078 PSORT swissprot:MOG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MOG_ECOLI PSORT-B swissprot:MOG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MOG_ECOLI PSORT2 swissprot:MOG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MOG_ECOLI Pfam PF00994 http://pfam.xfam.org/family/PF00994 Phobius swissprot:MOG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MOG_ECOLI PhylomeDB P0AF03 http://phylomedb.org/?seqid=P0AF03 ProteinModelPortal P0AF03 http://www.proteinmodelportal.org/query/uniprot/P0AF03 PubMed 10636880 http://www.ncbi.nlm.nih.gov/pubmed/10636880 PubMed 12372836 http://www.ncbi.nlm.nih.gov/pubmed/12372836 PubMed 15632135 http://www.ncbi.nlm.nih.gov/pubmed/15632135 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8400364 http://www.ncbi.nlm.nih.gov/pubmed/8400364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414550 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414550 RefSeq WP_001295414 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295414 SMART SM00852 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00852 SMR P0AF03 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AF03 STRING 511145.b0009 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0009&targetmode=cogs STRING COG0521 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0521&targetmode=cogs SUPFAM SSF53218 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53218 SWISS-2DPAGE P0AF03 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AF03 TIGRFAMs TIGR00177 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00177 UniProtKB MOG_ECOLI http://www.uniprot.org/uniprot/MOG_ECOLI UniProtKB-AC P0AF03 http://www.uniprot.org/uniprot/P0AF03 charge swissprot:MOG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MOG_ECOLI eggNOG COG0521 http://eggnogapi.embl.de/nog_data/html/tree/COG0521 eggNOG ENOG4108RIR http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108RIR epestfind swissprot:MOG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MOG_ECOLI garnier swissprot:MOG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MOG_ECOLI helixturnhelix swissprot:MOG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MOG_ECOLI hmoment swissprot:MOG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MOG_ECOLI iep swissprot:MOG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MOG_ECOLI inforesidue swissprot:MOG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MOG_ECOLI octanol swissprot:MOG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MOG_ECOLI pepcoil swissprot:MOG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MOG_ECOLI pepdigest swissprot:MOG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MOG_ECOLI pepinfo swissprot:MOG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MOG_ECOLI pepnet swissprot:MOG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MOG_ECOLI pepstats swissprot:MOG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MOG_ECOLI pepwheel swissprot:MOG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MOG_ECOLI pepwindow swissprot:MOG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MOG_ECOLI sigcleave swissprot:MOG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MOG_ECOLI ## Database ID URL or Descriptions # AltName CAN_ECOLI Carbonate dehydratase 2 # BRENDA 4.2.1 2026 # BioGrid 4259733 14 # CATALYTIC ACTIVITY H(2)CO(3) = CO(2) + H(2)O. {ECO:0000269|PubMed 11316870}. # COFACTOR CAN_ECOLI Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 11316870}; Note=Binds 1 zinc ion per subunit. {ECO 0000269|PubMed 11316870}; # EcoGene EG12319 can # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0004089 carbonate dehydratase activity; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_process GO:0015976 carbon utilization; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # Gene3D 3.40.1050.10 -; 1. # IntAct P61517 10 # InterPro IPR001765 Carbonic_anhydrase # InterPro IPR015892 Carbonic_anhydrase_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00910 Nitrogen metabolism # Organism CAN_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11002 PTHR11002 # PATRIC 32115355 VBIEscCol129921_0129 # PDB 1I6O X-ray; 2.20 A; A/B=1-220 # PDB 1I6P X-ray; 2.00 A; A=1-220 # PDB 1T75 X-ray; 2.50 A; A/B/D/E=1-220 # PDB 2ESF X-ray; 2.25 A; A/B=1-220 # PIR F64735 F64735 # PROSITE PS00704 PROK_CO2_ANHYDRASE_1 # PROSITE PS00705 PROK_CO2_ANHYDRASE_2 # Pfam PF00484 Pro_CA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CAN_ECOLI Carbonic anhydrase 2 # RefSeq NP_414668 NC_000913.3 # RefSeq WP_000651599 NZ_LN832404.1 # SIMILARITY Belongs to the beta-class carbonic anhydrase family. {ECO 0000305}. # SMART SM00947 Pro_CA # SUBUNIT Homodimer. {ECO:0000269|PubMed 11316870}. # SUPFAM SSF53056 SSF53056 # eggNOG COG0288 LUCA # eggNOG ENOG41077A9 Bacteria BLAST swissprot:CAN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CAN_ECOLI BioCyc ECOL316407:JW0122-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0122-MONOMER BioCyc EcoCyc:EG12319-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12319-MONOMER BioCyc MetaCyc:EG12319-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12319-MONOMER COG COG0288 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0288 DIP DIP-36168N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36168N DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1110/ps.46301 http://dx.doi.org/10.1110/ps.46301 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.2.1.1 {ECO:0000269|PubMed:11316870} http://www.genome.jp/dbget-bin/www_bget?EC:4.2.1.1 {ECO:0000269|PubMed:11316870} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 4.2.1.1 {ECO:0000269|PubMed:11316870} http://enzyme.expasy.org/EC/4.2.1.1 {ECO:0000269|PubMed:11316870} EchoBASE EB2224 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2224 EcoGene EG12319 http://www.ecogene.org/geneInfo.php?eg_id=EG12319 EnsemblBacteria AAC73237 http://www.ensemblgenomes.org/id/AAC73237 EnsemblBacteria AAC73237 http://www.ensemblgenomes.org/id/AAC73237 EnsemblBacteria BAB96701 http://www.ensemblgenomes.org/id/BAB96701 EnsemblBacteria BAB96701 http://www.ensemblgenomes.org/id/BAB96701 EnsemblBacteria BAB96701 http://www.ensemblgenomes.org/id/BAB96701 EnsemblBacteria b0126 http://www.ensemblgenomes.org/id/b0126 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004089 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004089 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_process GO:0015976 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015976 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.40.1050.10 http://www.cathdb.info/version/latest/superfamily/3.40.1050.10 GeneID 944832 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944832 HOGENOM HOG000125184 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125184&db=HOGENOM6 InParanoid P61517 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P61517 IntAct P61517 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P61517* IntEnz 4.2.1.1 {ECO:0000269|PubMed:11316870} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.2.1.1 {ECO:0000269|PubMed:11316870} InterPro IPR001765 http://www.ebi.ac.uk/interpro/entry/IPR001765 InterPro IPR015892 http://www.ebi.ac.uk/interpro/entry/IPR015892 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0122 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0122 KEGG_Gene eco:b0126 http://www.genome.jp/dbget-bin/www_bget?eco:b0126 KEGG_Orthology KO:K01673 http://www.genome.jp/dbget-bin/www_bget?KO:K01673 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Reaction rn:R00132 http://www.genome.jp/dbget-bin/www_bget?rn:R00132 KEGG_Reaction rn:R10092 http://www.genome.jp/dbget-bin/www_bget?rn:R10092 OMA VQEAWAR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VQEAWAR PANTHER PTHR11002 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11002 PDB 1I6O http://www.ebi.ac.uk/pdbe-srv/view/entry/1I6O PDB 1I6P http://www.ebi.ac.uk/pdbe-srv/view/entry/1I6P PDB 1T75 http://www.ebi.ac.uk/pdbe-srv/view/entry/1T75 PDB 2ESF http://www.ebi.ac.uk/pdbe-srv/view/entry/2ESF PDBsum 1I6O http://www.ebi.ac.uk/pdbsum/1I6O PDBsum 1I6P http://www.ebi.ac.uk/pdbsum/1I6P PDBsum 1T75 http://www.ebi.ac.uk/pdbsum/1T75 PDBsum 2ESF http://www.ebi.ac.uk/pdbsum/2ESF PROSITE PS00704 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00704 PROSITE PS00705 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00705 PSORT swissprot:CAN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CAN_ECOLI PSORT-B swissprot:CAN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CAN_ECOLI PSORT2 swissprot:CAN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CAN_ECOLI Pfam PF00484 http://pfam.xfam.org/family/PF00484 Phobius swissprot:CAN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CAN_ECOLI PhylomeDB P61517 http://phylomedb.org/?seqid=P61517 ProteinModelPortal P61517 http://www.proteinmodelportal.org/query/uniprot/P61517 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 11316870 http://www.ncbi.nlm.nih.gov/pubmed/11316870 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414668 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414668 RefSeq WP_000651599 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000651599 SMART SM00947 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00947 SMR P61517 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P61517 STRING 511145.b0126 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0126&targetmode=cogs STRING COG0288 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0288&targetmode=cogs SUPFAM SSF53056 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53056 UniProtKB CAN_ECOLI http://www.uniprot.org/uniprot/CAN_ECOLI UniProtKB-AC P61517 http://www.uniprot.org/uniprot/P61517 charge swissprot:CAN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CAN_ECOLI eggNOG COG0288 http://eggnogapi.embl.de/nog_data/html/tree/COG0288 eggNOG ENOG41077A9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41077A9 epestfind swissprot:CAN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CAN_ECOLI garnier swissprot:CAN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CAN_ECOLI helixturnhelix swissprot:CAN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CAN_ECOLI hmoment swissprot:CAN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CAN_ECOLI iep swissprot:CAN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CAN_ECOLI inforesidue swissprot:CAN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CAN_ECOLI octanol swissprot:CAN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CAN_ECOLI pepcoil swissprot:CAN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CAN_ECOLI pepdigest swissprot:CAN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CAN_ECOLI pepinfo swissprot:CAN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CAN_ECOLI pepnet swissprot:CAN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CAN_ECOLI pepstats swissprot:CAN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CAN_ECOLI pepwheel swissprot:CAN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CAN_ECOLI pepwindow swissprot:CAN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CAN_ECOLI sigcleave swissprot:CAN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CAN_ECOLI ## Database ID URL or Descriptions # AltName SODM_ECOLI MnSOD # BRENDA 1.15.1 2026 # BioGrid 4262227 62 # CATALYTIC ACTIVITY SODM_ECOLI 2 superoxide + 2 H(+) = O(2) + H(2)O(2). # COFACTOR Name=Mn(2+); Xref=ChEBI:CHEBI 29035; Note=Binds 1 Mn(2+) ion per subunit.; # EcoGene EG10953 sodA # FUNCTION SODM_ECOLI Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0004784 superoxide dismutase activity; IDA:EcoCyc. # GO_function GO:0016209 antioxidant activity; IMP:EcoCyc. # GO_function GO:0030145 manganese ion binding; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IDA:EcoliWiki. # GO_process GO:0006801 superoxide metabolic process; IDA:EcoliWiki. # GO_process GO:0006979 response to oxidative stress; IMP:EcoCyc. # GO_process GO:0009408 response to heat; IMP:EcoCyc. # GO_process GO:0010447 response to acidic pH; IMP:EcoCyc. # GO_process GO:0019430 removal of superoxide radicals; IDA:EcoliWiki. # GO_process GO:0055114 oxidation-reduction process; IDA:EcoliWiki. # GO_process GO:0071291 cellular response to selenium ion; IEP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # IntAct P00448 7 # InterPro IPR001189 Mn/Fe_SOD # InterPro IPR019831 Mn/Fe_SOD_N # InterPro IPR019832 Mn/Fe_SOD_C # InterPro IPR019833 Mn/Fe_SOD_BS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko04146 Peroxisome # KEGG_Pathway ko05016 Huntington's disease # Organism SODM_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11404 PTHR11404 # PATRIC 32123327 VBIEscCol129921_4024 # PDB 1D5N X-ray; 1.55 A; A/B/C/D=2-206 # PDB 1EN4 X-ray; 2.00 A; A/B/C/D=2-206 # PDB 1EN5 X-ray; 2.30 A; A/B/C/D=2-206 # PDB 1EN6 X-ray; 2.00 A; A/B/C/D=2-206 # PDB 1I08 X-ray; 2.20 A; A/B/C/D=2-206 # PDB 1I0H X-ray; 1.35 A; A/B=2-206 # PDB 1IX9 X-ray; 0.90 A; A/B=2-206 # PDB 1IXB X-ray; 0.90 A; A/B=2-206 # PDB 1MMM X-ray; 2.20 A; A/B=2-206 # PDB 1VEW X-ray; 2.10 A; A/B/C/D=2-206 # PDB 1ZLZ X-ray; 1.55 A; A/B=2-206 # PDB 3K9S X-ray; 1.55 A; A/B/C/D=2-206 # PDB 3OT7 X-ray; 1.90 A; A/B/C/D=2-206 # PIR A24141 DSECN # PIRSF PIRSF000349 SODismutase # PRINTS PR01703 MNSODISMTASE # PROSITE PS00088 SOD_MN # Pfam PF00081 Sod_Fe_N # Pfam PF02777 Sod_Fe_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SODM_ECOLI Superoxide dismutase [Mn] # RefSeq NP_418344 NC_000913.3 # RefSeq WP_000122641 NZ_LN832404.1 # SIMILARITY Belongs to the iron/manganese superoxide dismutase family. {ECO 0000305}. # SUBUNIT SODM_ECOLI Homodimer. # SUPFAM SSF46609 SSF46609 # SUPFAM SSF54719 SSF54719 # eggNOG COG0605 LUCA # eggNOG ENOG4105CK4 Bacteria BLAST swissprot:SODM_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SODM_ECOLI BioCyc ECOL316407:JW3879-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3879-MONOMER BioCyc EcoCyc:SUPEROX-DISMUTMN-MONOMER http://biocyc.org/getid?id=EcoCyc:SUPEROX-DISMUTMN-MONOMER BioCyc MetaCyc:SUPEROX-DISMUTMN-MONOMER http://biocyc.org/getid?id=MetaCyc:SUPEROX-DISMUTMN-MONOMER COG COG0605 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0605 DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1999.3506 http://dx.doi.org/10.1006/jmbi.1999.3506 DOI 10.1016/S0014-5793(96)31420-2 http://dx.doi.org/10.1016/S0014-5793(96)31420-2 DOI 10.1021/bi0018943 http://dx.doi.org/10.1021/bi0018943 DOI 10.1021/bi002403h http://dx.doi.org/10.1021/bi002403h DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/14.11.4577 http://dx.doi.org/10.1093/nar/14.11.4577 DOI 10.1093/nar/21.15.3391 http://dx.doi.org/10.1093/nar/21.15.3391 DOI 10.1099/00221287-138-6-1109 http://dx.doi.org/10.1099/00221287-138-6-1109 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.15.1.1 http://www.genome.jp/dbget-bin/www_bget?EC:1.15.1.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L19201 http://www.ebi.ac.uk/ena/data/view/L19201 EMBL M20984 http://www.ebi.ac.uk/ena/data/view/M20984 EMBL M85158 http://www.ebi.ac.uk/ena/data/view/M85158 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X03951 http://www.ebi.ac.uk/ena/data/view/X03951 EMBL X60699 http://www.ebi.ac.uk/ena/data/view/X60699 ENZYME 1.15.1.1 http://enzyme.expasy.org/EC/1.15.1.1 EchoBASE EB0946 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0946 EcoGene EG10953 http://www.ecogene.org/geneInfo.php?eg_id=EG10953 EnsemblBacteria AAC76890 http://www.ensemblgenomes.org/id/AAC76890 EnsemblBacteria AAC76890 http://www.ensemblgenomes.org/id/AAC76890 EnsemblBacteria BAE77401 http://www.ensemblgenomes.org/id/BAE77401 EnsemblBacteria BAE77401 http://www.ensemblgenomes.org/id/BAE77401 EnsemblBacteria BAE77401 http://www.ensemblgenomes.org/id/BAE77401 EnsemblBacteria b3908 http://www.ensemblgenomes.org/id/b3908 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004784 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004784 GO_function GO:0016209 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016209 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006801 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006801 GO_process GO:0006979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979 GO_process GO:0009408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009408 GO_process GO:0010447 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010447 GO_process GO:0019430 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019430 GO_process GO:0055114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114 GO_process GO:0071291 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071291 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 948403 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948403 HOGENOM HOG000013583 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000013583&db=HOGENOM6 InParanoid P00448 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P00448 IntAct P00448 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P00448* IntEnz 1.15.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.15.1.1 InterPro IPR001189 http://www.ebi.ac.uk/interpro/entry/IPR001189 InterPro IPR019831 http://www.ebi.ac.uk/interpro/entry/IPR019831 InterPro IPR019832 http://www.ebi.ac.uk/interpro/entry/IPR019832 InterPro IPR019833 http://www.ebi.ac.uk/interpro/entry/IPR019833 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW3879 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3879 KEGG_Gene eco:b3908 http://www.genome.jp/dbget-bin/www_bget?eco:b3908 KEGG_Orthology KO:K04564 http://www.genome.jp/dbget-bin/www_bget?KO:K04564 KEGG_Pathway ko04146 http://www.genome.jp/kegg-bin/show_pathway?ko04146 KEGG_Pathway ko05016 http://www.genome.jp/kegg-bin/show_pathway?ko05016 OMA TFFWEIM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TFFWEIM PANTHER PTHR11404 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11404 PDB 1D5N http://www.ebi.ac.uk/pdbe-srv/view/entry/1D5N PDB 1EN4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1EN4 PDB 1EN5 http://www.ebi.ac.uk/pdbe-srv/view/entry/1EN5 PDB 1EN6 http://www.ebi.ac.uk/pdbe-srv/view/entry/1EN6 PDB 1I08 http://www.ebi.ac.uk/pdbe-srv/view/entry/1I08 PDB 1I0H http://www.ebi.ac.uk/pdbe-srv/view/entry/1I0H PDB 1IX9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1IX9 PDB 1IXB http://www.ebi.ac.uk/pdbe-srv/view/entry/1IXB PDB 1MMM http://www.ebi.ac.uk/pdbe-srv/view/entry/1MMM PDB 1VEW http://www.ebi.ac.uk/pdbe-srv/view/entry/1VEW PDB 1ZLZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZLZ PDB 3K9S http://www.ebi.ac.uk/pdbe-srv/view/entry/3K9S PDB 3OT7 http://www.ebi.ac.uk/pdbe-srv/view/entry/3OT7 PDBsum 1D5N http://www.ebi.ac.uk/pdbsum/1D5N PDBsum 1EN4 http://www.ebi.ac.uk/pdbsum/1EN4 PDBsum 1EN5 http://www.ebi.ac.uk/pdbsum/1EN5 PDBsum 1EN6 http://www.ebi.ac.uk/pdbsum/1EN6 PDBsum 1I08 http://www.ebi.ac.uk/pdbsum/1I08 PDBsum 1I0H http://www.ebi.ac.uk/pdbsum/1I0H PDBsum 1IX9 http://www.ebi.ac.uk/pdbsum/1IX9 PDBsum 1IXB http://www.ebi.ac.uk/pdbsum/1IXB PDBsum 1MMM http://www.ebi.ac.uk/pdbsum/1MMM PDBsum 1VEW http://www.ebi.ac.uk/pdbsum/1VEW PDBsum 1ZLZ http://www.ebi.ac.uk/pdbsum/1ZLZ PDBsum 3K9S http://www.ebi.ac.uk/pdbsum/3K9S PDBsum 3OT7 http://www.ebi.ac.uk/pdbsum/3OT7 PRINTS PR01703 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR01703 PROSITE PS00088 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00088 PSORT swissprot:SODM_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SODM_ECOLI PSORT-B swissprot:SODM_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SODM_ECOLI PSORT2 swissprot:SODM_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SODM_ECOLI Pfam PF00081 http://pfam.xfam.org/family/PF00081 Pfam PF02777 http://pfam.xfam.org/family/PF02777 Phobius swissprot:SODM_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SODM_ECOLI PhylomeDB P00448 http://phylomedb.org/?seqid=P00448 ProteinModelPortal P00448 http://www.proteinmodelportal.org/query/uniprot/P00448 PubMed 10686094 http://www.ncbi.nlm.nih.gov/pubmed/10686094 PubMed 11141052 http://www.ncbi.nlm.nih.gov/pubmed/11141052 PubMed 11294629 http://www.ncbi.nlm.nih.gov/pubmed/11294629 PubMed 1339463 http://www.ncbi.nlm.nih.gov/pubmed/1339463 PubMed 1551902 http://www.ncbi.nlm.nih.gov/pubmed/1551902 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3131302 http://www.ncbi.nlm.nih.gov/pubmed/3131302 PubMed 3520487 http://www.ncbi.nlm.nih.gov/pubmed/3520487 PubMed 363708 http://www.ncbi.nlm.nih.gov/pubmed/363708 PubMed 8346018 http://www.ncbi.nlm.nih.gov/pubmed/8346018 PubMed 9003797 http://www.ncbi.nlm.nih.gov/pubmed/9003797 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_418344 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418344 RefSeq WP_000122641 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000122641 SMR P00448 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P00448 STRING 511145.b3908 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3908&targetmode=cogs STRING COG0605 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0605&targetmode=cogs SUPFAM SSF46609 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46609 SUPFAM SSF54719 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54719 SWISS-2DPAGE P00448 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P00448 UniProtKB SODM_ECOLI http://www.uniprot.org/uniprot/SODM_ECOLI UniProtKB-AC P00448 http://www.uniprot.org/uniprot/P00448 charge swissprot:SODM_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SODM_ECOLI eggNOG COG0605 http://eggnogapi.embl.de/nog_data/html/tree/COG0605 eggNOG ENOG4105CK4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CK4 epestfind swissprot:SODM_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SODM_ECOLI garnier swissprot:SODM_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SODM_ECOLI helixturnhelix swissprot:SODM_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SODM_ECOLI hmoment swissprot:SODM_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SODM_ECOLI iep swissprot:SODM_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SODM_ECOLI inforesidue swissprot:SODM_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SODM_ECOLI octanol swissprot:SODM_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SODM_ECOLI pepcoil swissprot:SODM_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SODM_ECOLI pepdigest swissprot:SODM_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SODM_ECOLI pepinfo swissprot:SODM_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SODM_ECOLI pepnet swissprot:SODM_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SODM_ECOLI pepstats swissprot:SODM_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SODM_ECOLI pepwheel swissprot:SODM_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SODM_ECOLI pepwindow swissprot:SODM_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SODM_ECOLI sigcleave swissprot:SODM_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SODM_ECOLI ## Database ID URL or Descriptions # BioGrid 4261603 16 # EcoGene EG11523 ybfC # IntAct P28915 3 # Organism YBFC_ECOLI Escherichia coli (strain K12) # PATRIC 32116601 VBIEscCol129921_0733 # PIR G64805 G64805 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBFC_ECOLI Uncharacterized protein YbfC # RefSeq NP_415232 NC_000913.3 # RefSeq WP_000832338 NZ_LN832404.1 # eggNOG ENOG4106R09 Bacteria # eggNOG ENOG410YGXJ LUCA BLAST swissprot:YBFC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBFC_ECOLI BioCyc ECOL316407:JW0693-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0693-MONOMER BioCyc EcoCyc:EG11523-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11523-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L02373 http://www.ebi.ac.uk/ena/data/view/L02373 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1485 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1485 EcoGene EG11523 http://www.ecogene.org/geneInfo.php?eg_id=EG11523 EnsemblBacteria AAC73798 http://www.ensemblgenomes.org/id/AAC73798 EnsemblBacteria AAC73798 http://www.ensemblgenomes.org/id/AAC73798 EnsemblBacteria BAA35362 http://www.ensemblgenomes.org/id/BAA35362 EnsemblBacteria BAA35362 http://www.ensemblgenomes.org/id/BAA35362 EnsemblBacteria BAA35362 http://www.ensemblgenomes.org/id/BAA35362 EnsemblBacteria b0704 http://www.ensemblgenomes.org/id/b0704 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947288 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947288 HOGENOM HOG000009380 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009380&db=HOGENOM6 IntAct P28915 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P28915* KEGG_Gene ecj:JW0693 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0693 KEGG_Gene eco:b0704 http://www.genome.jp/dbget-bin/www_bget?eco:b0704 OMA LIEIQHE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LIEIQHE PSORT swissprot:YBFC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBFC_ECOLI PSORT-B swissprot:YBFC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBFC_ECOLI PSORT2 swissprot:YBFC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBFC_ECOLI Phobius swissprot:YBFC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBFC_ECOLI ProteinModelPortal P28915 http://www.proteinmodelportal.org/query/uniprot/P28915 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8387990 http://www.ncbi.nlm.nih.gov/pubmed/8387990 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415232 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415232 RefSeq WP_000832338 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000832338 SMR P28915 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P28915 STRING 511145.b0704 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0704&targetmode=cogs UniProtKB YBFC_ECOLI http://www.uniprot.org/uniprot/YBFC_ECOLI UniProtKB-AC P28915 http://www.uniprot.org/uniprot/P28915 charge swissprot:YBFC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBFC_ECOLI eggNOG ENOG4106R09 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106R09 eggNOG ENOG410YGXJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG410YGXJ epestfind swissprot:YBFC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBFC_ECOLI garnier swissprot:YBFC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBFC_ECOLI helixturnhelix swissprot:YBFC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBFC_ECOLI hmoment swissprot:YBFC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBFC_ECOLI iep swissprot:YBFC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBFC_ECOLI inforesidue swissprot:YBFC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBFC_ECOLI octanol swissprot:YBFC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBFC_ECOLI pepcoil swissprot:YBFC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBFC_ECOLI pepdigest swissprot:YBFC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBFC_ECOLI pepinfo swissprot:YBFC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBFC_ECOLI pepnet swissprot:YBFC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBFC_ECOLI pepstats swissprot:YBFC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBFC_ECOLI pepwheel swissprot:YBFC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBFC_ECOLI pepwindow swissprot:YBFC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBFC_ECOLI sigcleave swissprot:YBFC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBFC_ECOLI ## Database ID URL or Descriptions # BRENDA 2.6.99 2026 # BioGrid 4260601 8 # CATALYTIC ACTIVITY PDXJ_ECOLI 1-deoxy-D-xylulose 5-phosphate + 3-amino-2- oxopropyl phosphate = pyridoxine 5'-phosphate + phosphate + 2 H(2)O. # CDD cd00003 PNPsynthase # EcoGene EG10693 pdxJ # FUNCTION PDXJ_ECOLI Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. {ECO 0000269|PubMed 10225425}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0033856 pyridoxine 5'-phosphate synthase activity; IDA:EcoCyc. # GO_process GO:0008615 pyridoxine biosynthetic process; IMP:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.20.70 -; 1. # HAMAP MF_00279 PdxJ # IntAct P0A794 5 # InterPro IPR004569 PyrdxlP_synth_PdxJ # InterPro IPR013785 Aldolase_TIM # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00750 Vitamin B6 metabolism # Organism PDXJ_ECOLI Escherichia coli (strain K12) # PATHWAY Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4- phosphate step 5/5. # PATRIC 32120527 VBIEscCol129921_2666 # PDB 1HO1 X-ray; 2.00 A; A/B/C/D=2-243 # PDB 1HO4 X-ray; 2.30 A; A/B/C/D=2-243 # PDB 1IXN X-ray; 2.30 A; A/B/C/D=2-243 # PDB 1IXO X-ray; 2.30 A; A/B/C/D=2-243 # PDB 1IXP X-ray; 2.30 A; A/B/C/D=2-243 # PDB 1IXQ X-ray; 2.30 A; A/B/C/D=2-243 # PDB 1M5W X-ray; 1.96 A; A/B/C/D/E/F/G/H=1-243 # PIR A42293 A42293 # Pfam PF03740 PdxJ # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PDXJ_ECOLI Pyridoxine 5'-phosphate synthase # RefSeq NP_417059 NC_000913.3 # RefSeq WP_001297412 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=D64044; Type=Frameshift; Positions=Several; Evidence={ECO 0000305}; # SIMILARITY Belongs to the PNP synthase family. {ECO 0000305}. # SUBCELLULAR LOCATION PDXJ_ECOLI Cytoplasm. # SUBUNIT PDXJ_ECOLI Homooctamer; tetramer of dimers. {ECO 0000269|PubMed 11286891, ECO 0000269|PubMed 12269807}. # SUPFAM SSF63892 SSF63892 # TIGRFAMs TIGR00559 pdxJ # UniPathway UPA00244 UER00313 # eggNOG COG0854 LUCA # eggNOG ENOG4105CSZ Bacteria BLAST swissprot:PDXJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PDXJ_ECOLI BioCyc ECOL316407:JW2548-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2548-MONOMER BioCyc EcoCyc:PDXJ-MONOMER http://biocyc.org/getid?id=EcoCyc:PDXJ-MONOMER BioCyc MetaCyc:PDXJ-MONOMER http://biocyc.org/getid?id=MetaCyc:PDXJ-MONOMER COG COG0854 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0854 DIP DIP-36215N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36215N DOI 10.1016/S0014-5793(99)00393-2 http://dx.doi.org/10.1016/S0014-5793(99)00393-2 DOI 10.1016/S0022-2836(02)00695-2 http://dx.doi.org/10.1016/S0022-2836(02)00695-2 DOI 10.1016/S0969-2126(01)00584-6 http://dx.doi.org/10.1016/S0969-2126(01)00584-6 DOI 10.1016/S1570-9639(03)00065-7 http://dx.doi.org/10.1016/S1570-9639(03)00065-7 DOI 10.1021/bi026292t http://dx.doi.org/10.1021/bi026292t DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1107/S0907444900007368 http://dx.doi.org/10.1107/S0907444900007368 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.6.99.2 http://www.genome.jp/dbget-bin/www_bget?EC:2.6.99.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D64044 http://www.ebi.ac.uk/ena/data/view/D64044 EMBL M74526 http://www.ebi.ac.uk/ena/data/view/M74526 EMBL M76470 http://www.ebi.ac.uk/ena/data/view/M76470 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36841 http://www.ebi.ac.uk/ena/data/view/U36841 ENZYME 2.6.99.2 http://enzyme.expasy.org/EC/2.6.99.2 EchoBASE EB0687 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0687 EcoGene EG10693 http://www.ecogene.org/geneInfo.php?eg_id=EG10693 EnsemblBacteria AAC75617 http://www.ensemblgenomes.org/id/AAC75617 EnsemblBacteria AAC75617 http://www.ensemblgenomes.org/id/AAC75617 EnsemblBacteria BAE76740 http://www.ensemblgenomes.org/id/BAE76740 EnsemblBacteria BAE76740 http://www.ensemblgenomes.org/id/BAE76740 EnsemblBacteria BAE76740 http://www.ensemblgenomes.org/id/BAE76740 EnsemblBacteria b2564 http://www.ensemblgenomes.org/id/b2564 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0033856 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033856 GO_process GO:0008615 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008615 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 947039 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947039 HAMAP MF_00279 http://hamap.expasy.org/unirule/MF_00279 HOGENOM HOG000258095 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000258095&db=HOGENOM6 InParanoid P0A794 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A794 IntAct P0A794 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A794* IntEnz 2.6.99.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.6.99.2 InterPro IPR004569 http://www.ebi.ac.uk/interpro/entry/IPR004569 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2548 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2548 KEGG_Gene eco:b2564 http://www.genome.jp/dbget-bin/www_bget?eco:b2564 KEGG_Orthology KO:K03474 http://www.genome.jp/dbget-bin/www_bget?KO:K03474 KEGG_Pathway ko00750 http://www.genome.jp/kegg-bin/show_pathway?ko00750 KEGG_Reaction rn:R05838 http://www.genome.jp/dbget-bin/www_bget?rn:R05838 MINT MINT-1227457 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1227457 OMA ERHIRYQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ERHIRYQ PDB 1HO1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1HO1 PDB 1HO4 http://www.ebi.ac.uk/pdbe-srv/view/entry/1HO4 PDB 1IXN http://www.ebi.ac.uk/pdbe-srv/view/entry/1IXN PDB 1IXO http://www.ebi.ac.uk/pdbe-srv/view/entry/1IXO PDB 1IXP http://www.ebi.ac.uk/pdbe-srv/view/entry/1IXP PDB 1IXQ http://www.ebi.ac.uk/pdbe-srv/view/entry/1IXQ PDB 1M5W http://www.ebi.ac.uk/pdbe-srv/view/entry/1M5W PDBsum 1HO1 http://www.ebi.ac.uk/pdbsum/1HO1 PDBsum 1HO4 http://www.ebi.ac.uk/pdbsum/1HO4 PDBsum 1IXN http://www.ebi.ac.uk/pdbsum/1IXN PDBsum 1IXO http://www.ebi.ac.uk/pdbsum/1IXO PDBsum 1IXP http://www.ebi.ac.uk/pdbsum/1IXP PDBsum 1IXQ http://www.ebi.ac.uk/pdbsum/1IXQ PDBsum 1M5W http://www.ebi.ac.uk/pdbsum/1M5W PSORT swissprot:PDXJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PDXJ_ECOLI PSORT-B swissprot:PDXJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PDXJ_ECOLI PSORT2 swissprot:PDXJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PDXJ_ECOLI Pfam PF03740 http://pfam.xfam.org/family/PF03740 Phobius swissprot:PDXJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PDXJ_ECOLI PhylomeDB P0A794 http://phylomedb.org/?seqid=P0A794 ProteinModelPortal P0A794 http://www.proteinmodelportal.org/query/uniprot/P0A794 PubMed 10225425 http://www.ncbi.nlm.nih.gov/pubmed/10225425 PubMed 10944349 http://www.ncbi.nlm.nih.gov/pubmed/10944349 PubMed 11286891 http://www.ncbi.nlm.nih.gov/pubmed/11286891 PubMed 12206776 http://www.ncbi.nlm.nih.gov/pubmed/12206776 PubMed 12269807 http://www.ncbi.nlm.nih.gov/pubmed/12269807 PubMed 12686115 http://www.ncbi.nlm.nih.gov/pubmed/12686115 PubMed 1537799 http://www.ncbi.nlm.nih.gov/pubmed/1537799 PubMed 1537800 http://www.ncbi.nlm.nih.gov/pubmed/1537800 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8636054 http://www.ncbi.nlm.nih.gov/pubmed/8636054 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417059 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417059 RefSeq WP_001297412 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001297412 SMR P0A794 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A794 STRING 511145.b2564 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2564&targetmode=cogs STRING COG0854 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0854&targetmode=cogs SUPFAM SSF63892 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63892 TIGRFAMs TIGR00559 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00559 UniProtKB PDXJ_ECOLI http://www.uniprot.org/uniprot/PDXJ_ECOLI UniProtKB-AC P0A794 http://www.uniprot.org/uniprot/P0A794 charge swissprot:PDXJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PDXJ_ECOLI eggNOG COG0854 http://eggnogapi.embl.de/nog_data/html/tree/COG0854 eggNOG ENOG4105CSZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CSZ epestfind swissprot:PDXJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PDXJ_ECOLI garnier swissprot:PDXJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PDXJ_ECOLI helixturnhelix swissprot:PDXJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PDXJ_ECOLI hmoment swissprot:PDXJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PDXJ_ECOLI iep swissprot:PDXJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PDXJ_ECOLI inforesidue swissprot:PDXJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PDXJ_ECOLI octanol swissprot:PDXJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PDXJ_ECOLI pepcoil swissprot:PDXJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PDXJ_ECOLI pepdigest swissprot:PDXJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PDXJ_ECOLI pepinfo swissprot:PDXJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PDXJ_ECOLI pepnet swissprot:PDXJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PDXJ_ECOLI pepstats swissprot:PDXJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PDXJ_ECOLI pepwheel swissprot:PDXJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PDXJ_ECOLI pepwindow swissprot:PDXJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PDXJ_ECOLI sigcleave swissprot:PDXJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PDXJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4260685 158 # EcoGene EG11886 mdoH # FUNCTION OPGH_ECOLI Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs). # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoliWiki. # GO_function GO:0016757 transferase activity, transferring glycosyl groups; IMP:EcoliWiki. # GO_function GO:0016758 transferase activity, transferring hexosyl groups; IBA:GO_Central. # GO_process GO:0006970 response to osmotic stress; IMP:EcoliWiki. # GO_process GO:0009250 glucan biosynthetic process; IMP:EcoliWiki. # GO_process GO:0051274 beta-glucan biosynthetic process; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016757 transferase activity, transferring glycosyl groups # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # HAMAP MF_01072 MdoH_OpgH # InterPro IPR001173 Glyco_trans_2-like # InterPro IPR023725 Glucans_biosynth_gluTrFase_H # InterPro IPR029044 Nucleotide-diphossugar_trans # KEGG_Brite ko01000 Enzymes # Organism OPGH_ECOLI Escherichia coli (strain K12) # PATHWAY OPGH_ECOLI Glycan metabolism; osmoregulated periplasmic glucan (OPG) biosynthesis. # PATRIC 32117337 VBIEscCol129921_1091 # PIR F64847 F64847 # Pfam PF00535 Glycos_transf_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName OPGH_ECOLI Glucans biosynthesis glucosyltransferase H # RefSeq NP_415567 NC_000913.3 # SIMILARITY Belongs to the glycosyltransferase 2 family. OpgH subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION OPGH_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF53448 SSF53448 # TCDB 4.D.3.1 the glycan glucosyl transferase (opgh) family # eggNOG COG2943 LUCA # eggNOG ENOG4105C3A Bacteria BLAST swissprot:OPGH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:OPGH_ECOLI BioCyc ECOL316407:JW1037-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1037-MONOMER BioCyc EcoCyc:EG11886-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11886-MONOMER COG CAZy: http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=CAZy: COG COG2943 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2943 COG GT2 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=GT2 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.1993.tb01959.x http://dx.doi.org/10.1111/j.1365-2958.1993.tb01959.x DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.4.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.4.1.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X64197 http://www.ebi.ac.uk/ena/data/view/X64197 ENZYME 2.4.1.- http://enzyme.expasy.org/EC/2.4.1.- EchoBASE EB1832 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1832 EcoGene EG11886 http://www.ecogene.org/geneInfo.php?eg_id=EG11886 EnsemblBacteria AAC74133 http://www.ensemblgenomes.org/id/AAC74133 EnsemblBacteria AAC74133 http://www.ensemblgenomes.org/id/AAC74133 EnsemblBacteria BAA35848 http://www.ensemblgenomes.org/id/BAA35848 EnsemblBacteria BAA35848 http://www.ensemblgenomes.org/id/BAA35848 EnsemblBacteria BAA35848 http://www.ensemblgenomes.org/id/BAA35848 EnsemblBacteria b1049 http://www.ensemblgenomes.org/id/b1049 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GO_function GO:0016758 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016758 GO_process GO:0006970 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006970 GO_process GO:0009250 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009250 GO_process GO:0051274 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051274 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 945624 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945624 HAMAP MF_01072 http://hamap.expasy.org/unirule/MF_01072 HOGENOM HOG000118994 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118994&db=HOGENOM6 InParanoid P62517 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P62517 IntAct P62517 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P62517* IntEnz 2.4.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.4.1 InterPro IPR001173 http://www.ebi.ac.uk/interpro/entry/IPR001173 InterPro IPR023725 http://www.ebi.ac.uk/interpro/entry/IPR023725 InterPro IPR029044 http://www.ebi.ac.uk/interpro/entry/IPR029044 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1037 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1037 KEGG_Gene eco:b1049 http://www.genome.jp/dbget-bin/www_bget?eco:b1049 KEGG_Orthology KO:K03669 http://www.genome.jp/dbget-bin/www_bget?KO:K03669 OMA QLYPLWP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QLYPLWP PSORT swissprot:OPGH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:OPGH_ECOLI PSORT-B swissprot:OPGH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:OPGH_ECOLI PSORT2 swissprot:OPGH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:OPGH_ECOLI Pfam PF00535 http://pfam.xfam.org/family/PF00535 Phobius swissprot:OPGH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:OPGH_ECOLI PhylomeDB P62517 http://phylomedb.org/?seqid=P62517 ProteinModelPortal P62517 http://www.proteinmodelportal.org/query/uniprot/P62517 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7934824 http://www.ncbi.nlm.nih.gov/pubmed/7934824 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9352918 http://www.ncbi.nlm.nih.gov/pubmed/9352918 RefSeq NP_415567 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415567 STRING 511145.b1049 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1049&targetmode=cogs STRING CAZy: http://string-db.org/newstring_cgi/show_network_section.pl?identifier=CAZy:&targetmode=cogs STRING COG2943 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2943&targetmode=cogs STRING GT2 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=GT2&targetmode=cogs SUPFAM SSF53448 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53448 TCDB 4.D.3.1 http://www.tcdb.org/search/result.php?tc=4.D.3.1 UniProtKB OPGH_ECOLI http://www.uniprot.org/uniprot/OPGH_ECOLI UniProtKB-AC P62517 http://www.uniprot.org/uniprot/P62517 charge swissprot:OPGH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:OPGH_ECOLI eggNOG COG2943 http://eggnogapi.embl.de/nog_data/html/tree/COG2943 eggNOG ENOG4105C3A http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C3A epestfind swissprot:OPGH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:OPGH_ECOLI garnier swissprot:OPGH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:OPGH_ECOLI helixturnhelix swissprot:OPGH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:OPGH_ECOLI hmoment swissprot:OPGH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:OPGH_ECOLI iep swissprot:OPGH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:OPGH_ECOLI inforesidue swissprot:OPGH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:OPGH_ECOLI octanol swissprot:OPGH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:OPGH_ECOLI pepcoil swissprot:OPGH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:OPGH_ECOLI pepdigest swissprot:OPGH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:OPGH_ECOLI pepinfo swissprot:OPGH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:OPGH_ECOLI pepnet swissprot:OPGH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:OPGH_ECOLI pepstats swissprot:OPGH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:OPGH_ECOLI pepwheel swissprot:OPGH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:OPGH_ECOLI pepwindow swissprot:OPGH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:OPGH_ECOLI sigcleave swissprot:OPGH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:OPGH_ECOLI ## Database ID URL or Descriptions # BioGrid 4259318 3 # CATALYTIC ACTIVITY 2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H(2)O = ribonucleoside triphosphate + thioredoxin. {ECO:0000269|PubMed 12655046}. # CDD cd01675 RNR_III # EcoGene EG11417 nrdD # GO_component GO:0031250 anaerobic ribonucleoside-triphosphate reductase complex; IMP:EcoliWiki. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0008270 zinc ion binding; IDA:EcoCyc. # GO_function GO:0008998 ribonucleoside-triphosphate reductase activity; IDA:EcoCyc. # GO_function GO:0051065 CTP reductase activity; IDA:EcoCyc. # GO_process GO:0006260 DNA replication; IEA:InterPro. # GO_process GO:0015949 nucleobase-containing small molecule interconversion; IMP:EcoliWiki. # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # INDUCTION Probably by NrdD-activating enzyme under anaerobic conditions by generation of an organic free radical. Exposure of activated NrdD to oxygen may result in cleavage at the glycine residue harboring its organic radical with loss of the 31 C- terminal AA. Induced 2-fold by hydroxyurea (PubMed:20005847). {ECO 0000269|PubMed:20005847}. # IntAct P28903 6 # InterPro IPR001150 Gly_radical # InterPro IPR005144 ATP-cone_dom # InterPro IPR012833 NrdD # InterPro IPR019777 Form_AcTrfase_GR_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00240 Pyrimidine metabolism # Organism NRDD_ECOLI Escherichia coli (strain K12) # PATRIC 32124049 VBIEscCol129921_4369 # PIR A47331 A47331 # PROSITE PS00850 GLY_RADICAL_1 # PROSITE PS51149 GLY_RADICAL_2 # PROSITE PS51161 ATP_CONE # Pfam PF03477 ATP-cone # Pfam PF13597 NRDD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NRDD_ECOLI Anaerobic ribonucleoside-triphosphate reductase # RefSeq NP_418659 NC_000913.3 # RefSeq WP_000187778 NZ_LN832404.1 # SIMILARITY Belongs to the anaerobic ribonucleoside-triphosphate reductase family. {ECO 0000305}. # SIMILARITY Contains 1 ATP-cone domain. {ECO:0000255|PROSITE- ProRule PRU00492}. # SIMILARITY Contains 1 glycine radical domain. {ECO:0000255|PROSITE-ProRule PRU00493}. # SUBUNIT NRDD_ECOLI Tetramer consisting of 2 alpha (NrdD) and 2 beta (NrdG) subunits. # TIGRFAMs TIGR02487 NrdD # eggNOG COG1328 LUCA # eggNOG ENOG4105CJD Bacteria BLAST swissprot:NRDD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NRDD_ECOLI BioCyc ECOL316407:JW4197-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4197-MONOMER BioCyc EcoCyc:RIBONUCLEOSIDE-TRIP-REDUCT-MONOMER http://biocyc.org/getid?id=EcoCyc:RIBONUCLEOSIDE-TRIP-REDUCT-MONOMER BioCyc MetaCyc:RIBONUCLEOSIDE-TRIP-REDUCT-MONOMER http://biocyc.org/getid?id=MetaCyc:RIBONUCLEOSIDE-TRIP-REDUCT-MONOMER COG COG1328 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1328 DIP DIP-10358N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10358N DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.0736456100 http://dx.doi.org/10.1073/pnas.0736456100 DOI 10.1073/pnas.90.2.577 http://dx.doi.org/10.1073/pnas.90.2.577 DOI 10.1074/jbc.270.6.2443 http://dx.doi.org/10.1074/jbc.270.6.2443 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.17.4.2 http://www.genome.jp/dbget-bin/www_bget?EC:1.17.4.2 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L06097 http://www.ebi.ac.uk/ena/data/view/L06097 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U06195 http://www.ebi.ac.uk/ena/data/view/U06195 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EMBL Z46865 http://www.ebi.ac.uk/ena/data/view/Z46865 ENZYME 1.17.4.2 http://enzyme.expasy.org/EC/1.17.4.2 EchoBASE EB1388 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1388 EcoGene EG11417 http://www.ecogene.org/geneInfo.php?eg_id=EG11417 EnsemblBacteria AAC77195 http://www.ensemblgenomes.org/id/AAC77195 EnsemblBacteria AAC77195 http://www.ensemblgenomes.org/id/AAC77195 EnsemblBacteria BAE78237 http://www.ensemblgenomes.org/id/BAE78237 EnsemblBacteria BAE78237 http://www.ensemblgenomes.org/id/BAE78237 EnsemblBacteria BAE78237 http://www.ensemblgenomes.org/id/BAE78237 EnsemblBacteria b4238 http://www.ensemblgenomes.org/id/b4238 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0031250 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031250 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0008998 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008998 GO_function GO:0051065 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051065 GO_process GO:0006260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006260 GO_process GO:0015949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015949 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GeneID 948755 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948755 HOGENOM HOG000222474 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000222474&db=HOGENOM6 InParanoid P28903 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P28903 IntAct P28903 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P28903* IntEnz 1.17.4.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.17.4.2 InterPro IPR001150 http://www.ebi.ac.uk/interpro/entry/IPR001150 InterPro IPR005144 http://www.ebi.ac.uk/interpro/entry/IPR005144 InterPro IPR012833 http://www.ebi.ac.uk/interpro/entry/IPR012833 InterPro IPR019777 http://www.ebi.ac.uk/interpro/entry/IPR019777 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4197 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4197 KEGG_Gene eco:b4238 http://www.genome.jp/dbget-bin/www_bget?eco:b4238 KEGG_Orthology KO:K00527 http://www.genome.jp/dbget-bin/www_bget?KO:K00527 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Reaction rn:R02014 http://www.genome.jp/dbget-bin/www_bget?rn:R02014 KEGG_Reaction rn:R02020 http://www.genome.jp/dbget-bin/www_bget?rn:R02020 KEGG_Reaction rn:R02022 http://www.genome.jp/dbget-bin/www_bget?rn:R02022 KEGG_Reaction rn:R02023 http://www.genome.jp/dbget-bin/www_bget?rn:R02023 OMA YSYDRVP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YSYDRVP PROSITE PS00850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00850 PROSITE PS51149 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51149 PROSITE PS51161 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51161 PSORT swissprot:NRDD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NRDD_ECOLI PSORT-B swissprot:NRDD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NRDD_ECOLI PSORT2 swissprot:NRDD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NRDD_ECOLI Pfam PF03477 http://pfam.xfam.org/family/PF03477 Pfam PF13597 http://pfam.xfam.org/family/PF13597 Phobius swissprot:NRDD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NRDD_ECOLI PhylomeDB P28903 http://phylomedb.org/?seqid=P28903 ProteinModelPortal P28903 http://www.proteinmodelportal.org/query/uniprot/P28903 PubMed 12655046 http://www.ncbi.nlm.nih.gov/pubmed/12655046 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 7852304 http://www.ncbi.nlm.nih.gov/pubmed/7852304 PubMed 8083158 http://www.ncbi.nlm.nih.gov/pubmed/8083158 PubMed 8421692 http://www.ncbi.nlm.nih.gov/pubmed/8421692 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418659 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418659 RefSeq WP_000187778 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000187778 SMR P28903 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P28903 STRING 511145.b4238 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4238&targetmode=cogs STRING COG1328 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1328&targetmode=cogs TIGRFAMs TIGR02487 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02487 UniProtKB NRDD_ECOLI http://www.uniprot.org/uniprot/NRDD_ECOLI UniProtKB-AC P28903 http://www.uniprot.org/uniprot/P28903 charge swissprot:NRDD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NRDD_ECOLI eggNOG COG1328 http://eggnogapi.embl.de/nog_data/html/tree/COG1328 eggNOG ENOG4105CJD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CJD epestfind swissprot:NRDD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NRDD_ECOLI garnier swissprot:NRDD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NRDD_ECOLI helixturnhelix swissprot:NRDD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NRDD_ECOLI hmoment swissprot:NRDD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NRDD_ECOLI iep swissprot:NRDD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NRDD_ECOLI inforesidue swissprot:NRDD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NRDD_ECOLI octanol swissprot:NRDD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NRDD_ECOLI pepcoil swissprot:NRDD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NRDD_ECOLI pepdigest swissprot:NRDD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NRDD_ECOLI pepinfo swissprot:NRDD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NRDD_ECOLI pepnet swissprot:NRDD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NRDD_ECOLI pepstats swissprot:NRDD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NRDD_ECOLI pepwheel swissprot:NRDD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NRDD_ECOLI pepwindow swissprot:NRDD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NRDD_ECOLI sigcleave swissprot:NRDD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NRDD_ECOLI ## Database ID URL or Descriptions # AltName 2-octaprenyl-6-hydroxyphenol methylase {ECO:0000255|HAMAP-Rule MF_00472} # AltName 3-demethylubiquinone-8 3-O-methyltransferase {ECO:0000255|HAMAP-Rule MF_00472} # BioGrid 4262129 5 # CATALYTIC ACTIVITY UBIG_ECOLI S-adenosyl-L-methionine + 3- demethylubiquinone-n = S-adenosyl-L-homocysteine + ubiquinone-n. {ECO 0000255|HAMAP-Rule MF_00472, ECO 0000269|PubMed 10419476}. # CATALYTIC ACTIVITY UBIG_ECOLI S-adenosyl-L-methionine + 3-(all-trans- polyprenyl)benzene-1,2-diol = S-adenosyl-L-homocysteine + 2- methoxy-6-(all-trans-polyprenyl)phenol. {ECO 0000255|HAMAP- Rule MF_00472, ECO 0000269|PubMed 10419476}. # EcoGene EG11143 ubiG # FUNCTION UBIG_ECOLI O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway. {ECO 0000255|HAMAP- Rule MF_00472, ECO 0000269|PubMed 10419476}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008425 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity; IEA:InterPro. # GO_function GO:0008689 3-demethylubiquinone-9 3-O-methyltransferase activity; IEA:UniProtKB-EC. # GO_function GO:0008757 S-adenosylmethionine-dependent methyltransferase activity; IBA:GO_Central. # GO_function GO:0043431 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase activity; IDA:EcoCyc. # GO_function GO:0102004 2-octaprenyl-6-hydroxyphenol methylase activity; IEA:UniProtKB-EC. # GO_process GO:0006744 ubiquinone biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.150 -; 1. # HAMAP MF_00472 UbiG # INTERACTION UBIG_ECOLI P61175 rplV; NbExp=2; IntAct=EBI-559367, EBI-542255; # IntAct P17993 19 # InterPro IPR010233 UbiG_MeTrfase # InterPro IPR029063 SAM-dependent_MTases # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00130 Ubiquinone and other terpenoid-quinone biosynthesis # Organism UBIG_ECOLI Escherichia coli (strain K12) # PATHWAY Cofactor biosynthesis; ubiquinone biosynthesis. {ECO:0000255|HAMAP-Rule MF_00472}. # PATRIC 32119823 VBIEscCol129921_2321 # PDB 4KDC X-ray; 2.09 A; A=1-240 # PDB 4KDR X-ray; 2.00 A; A=1-159, A=188-240 # PDB 5DPM X-ray; 2.10 A; A=1-240 # PIR A47682 A47682 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Ubiquinone biosynthesis O-methyltransferase {ECO:0000255|HAMAP-Rule MF_00472} # RefSeq NP_416735 NC_000913.3 # RefSeq WP_000990765 NZ_LN832404.1 # SIMILARITY Belongs to the methyltransferase superfamily. UbiG/COQ3 family. {ECO:0000255|HAMAP-Rule MF_00472}. # SUBUNIT Homodimer. {ECO 0000305}. # SUPFAM SSF53335 SSF53335 # TIGRFAMs TIGR01983 UbiG # eggNOG COG2227 LUCA # eggNOG ENOG4107RFD Bacteria BLAST swissprot:UBIG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UBIG_ECOLI BioCyc ECOL316407:JW2226-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2226-MONOMER BioCyc EcoCyc:DHHB-METHYLTRANSFER-MONOMER http://biocyc.org/getid?id=EcoCyc:DHHB-METHYLTRANSFER-MONOMER BioCyc MetaCyc:DHHB-METHYLTRANSFER-MONOMER http://biocyc.org/getid?id=MetaCyc:DHHB-METHYLTRANSFER-MONOMER COG COG2227 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2227 DIP DIP-11070N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11070N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.274.31.21665 http://dx.doi.org/10.1074/jbc.274.31.21665 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1099/00221287-138-10-2101 http://dx.doi.org/10.1099/00221287-138-10-2101 DOI 10.1111/j.1365-2958.1987.tb01932.x http://dx.doi.org/10.1111/j.1365-2958.1987.tb01932.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.1.222 {ECO:0000255|HAMAP-Rule:MF_00472} http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.222 {ECO:0000255|HAMAP-Rule:MF_00472} EC_number EC:2.1.1.64 {ECO:0000255|HAMAP-Rule:MF_00472} http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.64 {ECO:0000255|HAMAP-Rule:MF_00472} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M87509 http://www.ebi.ac.uk/ena/data/view/M87509 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL Y00544 http://www.ebi.ac.uk/ena/data/view/Y00544 ENZYME 2.1.1.222 {ECO:0000255|HAMAP-Rule:MF_00472} http://enzyme.expasy.org/EC/2.1.1.222 {ECO:0000255|HAMAP-Rule:MF_00472} ENZYME 2.1.1.64 {ECO:0000255|HAMAP-Rule:MF_00472} http://enzyme.expasy.org/EC/2.1.1.64 {ECO:0000255|HAMAP-Rule:MF_00472} EchoBASE EB1133 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1133 EcoGene EG11143 http://www.ecogene.org/geneInfo.php?eg_id=EG11143 EnsemblBacteria AAC75292 http://www.ensemblgenomes.org/id/AAC75292 EnsemblBacteria AAC75292 http://www.ensemblgenomes.org/id/AAC75292 EnsemblBacteria BAA16049 http://www.ensemblgenomes.org/id/BAA16049 EnsemblBacteria BAA16049 http://www.ensemblgenomes.org/id/BAA16049 EnsemblBacteria BAA16049 http://www.ensemblgenomes.org/id/BAA16049 EnsemblBacteria b2232 http://www.ensemblgenomes.org/id/b2232 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008425 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008425 GO_function GO:0008689 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008689 GO_function GO:0008757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008757 GO_function GO:0043431 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043431 GO_function GO:0102004 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0102004 GO_process GO:0006744 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006744 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 GeneID 946607 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946607 HAMAP MF_00472 http://hamap.expasy.org/unirule/MF_00472 HOGENOM HOG000278065 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278065&db=HOGENOM6 InParanoid P17993 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P17993 IntAct P17993 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P17993* IntEnz 2.1.1.222 {ECO:0000255|HAMAP-Rule:MF_00472} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.222 {ECO:0000255|HAMAP-Rule:MF_00472} IntEnz 2.1.1.64 {ECO:0000255|HAMAP-Rule:MF_00472} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.64 {ECO:0000255|HAMAP-Rule:MF_00472} InterPro IPR010233 http://www.ebi.ac.uk/interpro/entry/IPR010233 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2226 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2226 KEGG_Gene eco:b2232 http://www.genome.jp/dbget-bin/www_bget?eco:b2232 KEGG_Orthology KO:K00568 http://www.genome.jp/dbget-bin/www_bget?KO:K00568 KEGG_Pathway ko00130 http://www.genome.jp/kegg-bin/show_pathway?ko00130 KEGG_Reaction rn:R04988 http://www.genome.jp/dbget-bin/www_bget?rn:R04988 KEGG_Reaction rn:R05614 http://www.genome.jp/dbget-bin/www_bget?rn:R05614 KEGG_Reaction rn:R08769 http://www.genome.jp/dbget-bin/www_bget?rn:R08769 KEGG_Reaction rn:R08781 http://www.genome.jp/dbget-bin/www_bget?rn:R08781 MINT MINT-1254635 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1254635 OMA HDWEKFV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HDWEKFV PDB 4KDC http://www.ebi.ac.uk/pdbe-srv/view/entry/4KDC PDB 4KDR http://www.ebi.ac.uk/pdbe-srv/view/entry/4KDR PDB 5DPM http://www.ebi.ac.uk/pdbe-srv/view/entry/5DPM PDBsum 4KDC http://www.ebi.ac.uk/pdbsum/4KDC PDBsum 4KDR http://www.ebi.ac.uk/pdbsum/4KDR PDBsum 5DPM http://www.ebi.ac.uk/pdbsum/5DPM PSORT swissprot:UBIG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UBIG_ECOLI PSORT-B swissprot:UBIG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UBIG_ECOLI PSORT2 swissprot:UBIG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UBIG_ECOLI Phobius swissprot:UBIG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UBIG_ECOLI PhylomeDB P17993 http://phylomedb.org/?seqid=P17993 ProteinModelPortal P17993 http://www.proteinmodelportal.org/query/uniprot/P17993 PubMed 10419476 http://www.ncbi.nlm.nih.gov/pubmed/10419476 PubMed 1479344 http://www.ncbi.nlm.nih.gov/pubmed/1479344 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2834621 http://www.ncbi.nlm.nih.gov/pubmed/2834621 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416735 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416735 RefSeq WP_000990765 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000990765 SMR P17993 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P17993 STRING 511145.b2232 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2232&targetmode=cogs STRING COG2227 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2227&targetmode=cogs SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 TIGRFAMs TIGR01983 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01983 UniProtKB UBIG_ECOLI http://www.uniprot.org/uniprot/UBIG_ECOLI UniProtKB-AC P17993 http://www.uniprot.org/uniprot/P17993 charge swissprot:UBIG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UBIG_ECOLI eggNOG COG2227 http://eggnogapi.embl.de/nog_data/html/tree/COG2227 eggNOG ENOG4107RFD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107RFD epestfind swissprot:UBIG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UBIG_ECOLI garnier swissprot:UBIG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UBIG_ECOLI helixturnhelix swissprot:UBIG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UBIG_ECOLI hmoment swissprot:UBIG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UBIG_ECOLI iep swissprot:UBIG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UBIG_ECOLI inforesidue swissprot:UBIG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UBIG_ECOLI octanol swissprot:UBIG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UBIG_ECOLI pepcoil swissprot:UBIG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UBIG_ECOLI pepdigest swissprot:UBIG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UBIG_ECOLI pepinfo swissprot:UBIG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UBIG_ECOLI pepnet swissprot:UBIG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UBIG_ECOLI pepstats swissprot:UBIG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UBIG_ECOLI pepwheel swissprot:UBIG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UBIG_ECOLI pepwindow swissprot:UBIG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UBIG_ECOLI sigcleave swissprot:UBIG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UBIG_ECOLI ## Database ID URL or Descriptions # EcoGene EG14444 ylcI # InterPro IPR025030 DUF3950 # Organism YLCI_ECOLI Escherichia coli (strain K12) # PATRIC 32116286 VBIEscCol129921_0583 # Pfam PF13132 DUF3950 # Proteomes UP000000625 Chromosome # RecName YLCI_ECOLI Uncharacterized protein YlcI # RefSeq WP_001421937 NZ_LN832404.1 # RefSeq YP_001165309 NC_000913.3 # eggNOG ENOG4106YSC Bacteria # eggNOG ENOG410XYTI LUCA BLAST swissprot:YLCI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YLCI_ECOLI BioCyc EcoCyc:MONOMER0-2814 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2814 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EcoGene EG14444 http://www.ecogene.org/geneInfo.php?eg_id=EG14444 EnsemblBacteria ABP93436 http://www.ensemblgenomes.org/id/ABP93436 EnsemblBacteria ABP93436 http://www.ensemblgenomes.org/id/ABP93436 EnsemblBacteria b4589 http://www.ensemblgenomes.org/id/b4589 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 5061499 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5061499 HOGENOM HOG000009884 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009884&db=HOGENOM6 InterPro IPR025030 http://www.ebi.ac.uk/interpro/entry/IPR025030 KEGG_Gene eco:b4589 http://www.genome.jp/dbget-bin/www_bget?eco:b4589 OMA EACREKA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=EACREKA PSORT swissprot:YLCI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YLCI_ECOLI PSORT-B swissprot:YLCI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YLCI_ECOLI PSORT2 swissprot:YLCI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YLCI_ECOLI Pfam PF13132 http://pfam.xfam.org/family/PF13132 Phobius swissprot:YLCI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YLCI_ECOLI ProteinModelPortal A5A607 http://www.proteinmodelportal.org/query/uniprot/A5A607 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001421937 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001421937 RefSeq YP_001165309 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001165309 STRING 511145.b4589 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4589&targetmode=cogs UniProtKB YLCI_ECOLI http://www.uniprot.org/uniprot/YLCI_ECOLI UniProtKB-AC A5A607 http://www.uniprot.org/uniprot/A5A607 charge swissprot:YLCI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YLCI_ECOLI eggNOG ENOG4106YSC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106YSC eggNOG ENOG410XYTI http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XYTI epestfind swissprot:YLCI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YLCI_ECOLI garnier swissprot:YLCI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YLCI_ECOLI helixturnhelix swissprot:YLCI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YLCI_ECOLI hmoment swissprot:YLCI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YLCI_ECOLI iep swissprot:YLCI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YLCI_ECOLI inforesidue swissprot:YLCI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YLCI_ECOLI octanol swissprot:YLCI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YLCI_ECOLI pepcoil swissprot:YLCI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YLCI_ECOLI pepdigest swissprot:YLCI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YLCI_ECOLI pepinfo swissprot:YLCI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YLCI_ECOLI pepnet swissprot:YLCI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YLCI_ECOLI pepstats swissprot:YLCI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YLCI_ECOLI pepwheel swissprot:YLCI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YLCI_ECOLI pepwindow swissprot:YLCI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YLCI_ECOLI sigcleave swissprot:YLCI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YLCI_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES pH dependence: Optimum pH is 8.5-9.0.; Temperature dependence Optimum temperature is 65-70 degrees Celsius.; # BRENDA 4.1.2.48 2026 # BioGrid 4262099 12 # CATALYTIC ACTIVITY L-allo-threonine = glycine + acetaldehyde. {ECO:0000269|PubMed 9692922}. # CATALYTIC ACTIVITY L-threonine = glycine + acetaldehyde. {ECO:0000269|PubMed 9692922}. # COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI 597326; # EcoGene EG13690 ltaE # FUNCTION LTAE_ECOLI Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde. L-threo-phenylserine and L- erythro-phenylserine are also good substrates. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008732 L-allo-threonine aldolase activity; IDA:EcoCyc. # GO_function GO:0030170 pyridoxal phosphate binding; IDA:EcoCyc. # GO_function GO:0050179 phenylserine aldolase activity; IDA:EcoCyc. # GO_process GO:0006567 threonine catabolic process; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0009056 catabolic process # Gene3D 3.40.640.10 -; 1. # Gene3D 3.90.1150.10 -; 1. # INTERACTION LTAE_ECOLI Self; NbExp=2; IntAct=EBI-1120660, EBI-1120660; # InterPro IPR001597 ArAA_b-elim_lyase/Thr_aldolase # InterPro IPR015421 PyrdxlP-dep_Trfase_major_sub1 # InterPro IPR015422 PyrdxlP-dep_Trfase_major_sub2 # InterPro IPR015424 PyrdxlP-dep_Trfase # InterPro IPR023603 Threonine_aldolase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00260 Glycine, serine and threonine metabolism # Organism LTAE_ECOLI Escherichia coli (strain K12) # PATRIC 32116947 VBIEscCol129921_0899 # PDB 3WLX X-ray; 2.51 A; A/B=1-333 # PIR F64825 F64825 # PIRSF PIRSF017617 Thr_aldolase # Pfam PF01212 Beta_elim_lyase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName LTAE_ECOLI Low specificity L-threonine aldolase # RefSeq NP_415391 NC_000913.3 # RefSeq WP_000566376 NZ_LN832404.1 # SIMILARITY Belongs to the threonine aldolase family. {ECO 0000305}. # SUBUNIT Homotetramer. {ECO 0000305}. # SUPFAM SSF53383 SSF53383 # eggNOG COG2008 LUCA # eggNOG ENOG4105C5W Bacteria BLAST swissprot:LTAE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:LTAE_ECOLI BioCyc ECOL316407:JW0854-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0854-MONOMER BioCyc EcoCyc:LTAA-MONOMER http://biocyc.org/getid?id=EcoCyc:LTAA-MONOMER BioCyc MetaCyc:LTAA-MONOMER http://biocyc.org/getid?id=MetaCyc:LTAA-MONOMER COG COG2008 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2008 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1432-1327.1998.2550220.x http://dx.doi.org/10.1046/j.1432-1327.1998.2550220.x DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:4.1.2.48 http://www.genome.jp/dbget-bin/www_bget?EC:4.1.2.48 EMBL AB005050 http://www.ebi.ac.uk/ena/data/view/AB005050 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 4.1.2.48 http://enzyme.expasy.org/EC/4.1.2.48 EchoBASE EB3454 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3454 EcoGene EG13690 http://www.ecogene.org/geneInfo.php?eg_id=EG13690 EnsemblBacteria AAC73957 http://www.ensemblgenomes.org/id/AAC73957 EnsemblBacteria AAC73957 http://www.ensemblgenomes.org/id/AAC73957 EnsemblBacteria BAA35584 http://www.ensemblgenomes.org/id/BAA35584 EnsemblBacteria BAA35584 http://www.ensemblgenomes.org/id/BAA35584 EnsemblBacteria BAA35584 http://www.ensemblgenomes.org/id/BAA35584 EnsemblBacteria b0870 http://www.ensemblgenomes.org/id/b0870 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008732 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008732 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_function GO:0050179 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050179 GO_process GO:0006567 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006567 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 Gene3D 3.40.640.10 http://www.cathdb.info/version/latest/superfamily/3.40.640.10 Gene3D 3.90.1150.10 http://www.cathdb.info/version/latest/superfamily/3.90.1150.10 GeneID 944955 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944955 HOGENOM HOG000219824 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219824&db=HOGENOM6 InParanoid P75823 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75823 IntAct P75823 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75823* IntEnz 4.1.2.48 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.2.48 InterPro IPR001597 http://www.ebi.ac.uk/interpro/entry/IPR001597 InterPro IPR015421 http://www.ebi.ac.uk/interpro/entry/IPR015421 InterPro IPR015422 http://www.ebi.ac.uk/interpro/entry/IPR015422 InterPro IPR015424 http://www.ebi.ac.uk/interpro/entry/IPR015424 InterPro IPR023603 http://www.ebi.ac.uk/interpro/entry/IPR023603 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0854 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0854 KEGG_Gene eco:b0870 http://www.genome.jp/dbget-bin/www_bget?eco:b0870 KEGG_Orthology KO:K01620 http://www.genome.jp/dbget-bin/www_bget?KO:K01620 KEGG_Pathway ko00260 http://www.genome.jp/kegg-bin/show_pathway?ko00260 KEGG_Reaction rn:R00751 http://www.genome.jp/dbget-bin/www_bget?rn:R00751 KEGG_Reaction rn:R06171 http://www.genome.jp/dbget-bin/www_bget?rn:R06171 OMA TMTNQVA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TMTNQVA PDB 3WLX http://www.ebi.ac.uk/pdbe-srv/view/entry/3WLX PDBsum 3WLX http://www.ebi.ac.uk/pdbsum/3WLX PSORT swissprot:LTAE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:LTAE_ECOLI PSORT-B swissprot:LTAE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:LTAE_ECOLI PSORT2 swissprot:LTAE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:LTAE_ECOLI Pfam PF01212 http://pfam.xfam.org/family/PF01212 Phobius swissprot:LTAE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:LTAE_ECOLI PhylomeDB P75823 http://phylomedb.org/?seqid=P75823 ProteinModelPortal P75823 http://www.proteinmodelportal.org/query/uniprot/P75823 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9692922 http://www.ncbi.nlm.nih.gov/pubmed/9692922 RefSeq NP_415391 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415391 RefSeq WP_000566376 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000566376 SMR P75823 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75823 STRING 511145.b0870 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0870&targetmode=cogs STRING COG2008 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2008&targetmode=cogs SUPFAM SSF53383 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53383 UniProtKB LTAE_ECOLI http://www.uniprot.org/uniprot/LTAE_ECOLI UniProtKB-AC P75823 http://www.uniprot.org/uniprot/P75823 charge swissprot:LTAE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:LTAE_ECOLI eggNOG COG2008 http://eggnogapi.embl.de/nog_data/html/tree/COG2008 eggNOG ENOG4105C5W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C5W epestfind swissprot:LTAE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:LTAE_ECOLI garnier swissprot:LTAE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:LTAE_ECOLI helixturnhelix swissprot:LTAE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:LTAE_ECOLI hmoment swissprot:LTAE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:LTAE_ECOLI iep swissprot:LTAE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:LTAE_ECOLI inforesidue swissprot:LTAE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:LTAE_ECOLI octanol swissprot:LTAE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:LTAE_ECOLI pepcoil swissprot:LTAE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:LTAE_ECOLI pepdigest swissprot:LTAE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:LTAE_ECOLI pepinfo swissprot:LTAE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:LTAE_ECOLI pepnet swissprot:LTAE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:LTAE_ECOLI pepstats swissprot:LTAE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:LTAE_ECOLI pepwheel swissprot:LTAE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:LTAE_ECOLI pepwindow swissprot:LTAE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:LTAE_ECOLI sigcleave swissprot:LTAE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:LTAE_ECOLI ## Database ID URL or Descriptions # AltName MBHT_ECOLI Membrane-bound hydrogenase 2 small subunit # AltName MBHT_ECOLI NiFe hydrogenase # BioGrid 4261299 221 # CATALYTIC ACTIVITY MBHT_ECOLI H(2) + A = AH(2). # COFACTOR MBHT_ECOLI Name=[3Fe-4S] cluster; Xref=ChEBI CHEBI 21137; Evidence={ECO 0000250}; Note=Binds 1 [3Fe-4S] cluster. {ECO 0000250}; # COFACTOR MBHT_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000250}; Note=Binds 2 [4Fe-4S] clusters. {ECO 0000250}; # EcoGene EG13006 hybO # FUNCTION MBHT_ECOLI This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD2 is involved in hydrogen uptake. # GO_component GO:0009375 ferredoxin hydrogenase complex; IEA:InterPro. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_component GO:0031236 extrinsic component of periplasmic side of plasma membrane; IDA:EcoCyc. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_function GO:0008901 ferredoxin hydrogenase activity; IEA:InterPro. # GO_function GO:0033748 hydrogenase (acceptor) activity; IEA:UniProtKB-EC. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051536 iron-sulfur cluster binding; ISM:EcoCyc. # GO_function GO:0051538 3 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.700 -; 1. # Gene3D 4.10.480.10 -; 1. # INTERACTION MBHT_ECOLI P0AAN1 hybE; NbExp=4; IntAct=EBI-552619, EBI-552588; # IntAct P69741 17 # InterPro IPR001821 NiFe_hydrogenase_ssu # InterPro IPR006137 NADH_UbQ_OxRdtase-like_20kDa # InterPro IPR006311 TAT_signal # InterPro IPR019546 TAT_signal_bac_arc # InterPro IPR027394 Cytochrome-c3_hydrogenase_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00633 Nitrotoluene degradation # Organism MBHT_ECOLI Escherichia coli (strain K12) # PANTHER PTHR30013 PTHR30013 # PATRIC 32121410 VBIEscCol129921_3092 # PIR C65086 C65086 # PIRSF PIRSF000310 NiFe_hyd_ssu # PRINTS PR00614 NIHGNASESMLL # PROSITE PS51318 TAT # PTM MBHT_ECOLI Exported by the Tat system. The position of the signal peptide cleavage has been experimentally proven. Can also be exported by the Sec system. # Pfam PF01058 Oxidored_q6 # Pfam PF14720 NiFe_hyd_SSU_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName MBHT_ECOLI Hydrogenase-2 small chain # RefSeq NP_417471 NC_000913.3 # RefSeq WP_000145410 NZ_LN832404.1 # SIMILARITY Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family. {ECO 0000305}. # SUBCELLULAR LOCATION MBHT_ECOLI Cell membrane; Peripheral membrane protein; Periplasmic side. Periplasm. # SUBUNIT MBHT_ECOLI Heterodimer of a large and a small subunit. # TIGRFAMs TIGR00391 hydA # TIGRFAMs TIGR01409 TAT_signal_seq # eggNOG COG1740 LUCA # eggNOG ENOG4105E3S Bacteria BLAST swissprot:MBHT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:MBHT_ECOLI BioCyc ECOL316407:JW2965-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2965-MONOMER BioCyc EcoCyc:MONOMER0-145 http://biocyc.org/getid?id=EcoCyc:MONOMER0-145 BioCyc MetaCyc:MONOMER0-145 http://biocyc.org/getid?id=MetaCyc:MONOMER0-145 COG COG1740 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1740 DIP DIP-36024N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36024N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1432-1327.1998.2550746.x http://dx.doi.org/10.1046/j.1432-1327.1998.2550746.x DOI 10.1074/jbc.M610507200 http://dx.doi.org/10.1074/jbc.M610507200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.12.99.6 http://www.genome.jp/dbget-bin/www_bget?EC:1.12.99.6 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U28377 http://www.ebi.ac.uk/ena/data/view/U28377 ENZYME 1.12.99.6 http://enzyme.expasy.org/EC/1.12.99.6 EchoBASE EB2828 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2828 EcoGene EG13006 http://www.ecogene.org/geneInfo.php?eg_id=EG13006 EnsemblBacteria AAC76033 http://www.ensemblgenomes.org/id/AAC76033 EnsemblBacteria AAC76033 http://www.ensemblgenomes.org/id/AAC76033 EnsemblBacteria BAE77058 http://www.ensemblgenomes.org/id/BAE77058 EnsemblBacteria BAE77058 http://www.ensemblgenomes.org/id/BAE77058 EnsemblBacteria BAE77058 http://www.ensemblgenomes.org/id/BAE77058 EnsemblBacteria b2997 http://www.ensemblgenomes.org/id/b2997 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009375 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009375 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_component GO:0031236 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031236 GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0008901 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008901 GO_function GO:0033748 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033748 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051536 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051536 GO_function GO:0051538 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051538 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.700 http://www.cathdb.info/version/latest/superfamily/3.40.50.700 Gene3D 4.10.480.10 http://www.cathdb.info/version/latest/superfamily/4.10.480.10 GeneID 945902 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945902 HOGENOM HOG000278822 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000278822&db=HOGENOM6 InParanoid P69741 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P69741 IntAct P69741 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69741* IntEnz 1.12.99.6 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.12.99.6 InterPro IPR001821 http://www.ebi.ac.uk/interpro/entry/IPR001821 InterPro IPR006137 http://www.ebi.ac.uk/interpro/entry/IPR006137 InterPro IPR006311 http://www.ebi.ac.uk/interpro/entry/IPR006311 InterPro IPR019546 http://www.ebi.ac.uk/interpro/entry/IPR019546 InterPro IPR027394 http://www.ebi.ac.uk/interpro/entry/IPR027394 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2965 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2965 KEGG_Gene eco:b2997 http://www.genome.jp/dbget-bin/www_bget?eco:b2997 KEGG_Orthology KO:K06282 http://www.genome.jp/dbget-bin/www_bget?KO:K06282 KEGG_Pathway ko00633 http://www.genome.jp/kegg-bin/show_pathway?ko00633 KEGG_Reaction rn:R08034 http://www.genome.jp/dbget-bin/www_bget?rn:R08034 MINT MINT-8046452 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-8046452 OMA RSFNAHN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RSFNAHN PANTHER PTHR30013 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR30013 PRINTS PR00614 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00614 PROSITE PS51318 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51318 PSORT swissprot:MBHT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:MBHT_ECOLI PSORT-B swissprot:MBHT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:MBHT_ECOLI PSORT2 swissprot:MBHT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:MBHT_ECOLI Pfam PF01058 http://pfam.xfam.org/family/PF01058 Pfam PF14720 http://pfam.xfam.org/family/PF14720 Phobius swissprot:MBHT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:MBHT_ECOLI PhylomeDB P69741 http://phylomedb.org/?seqid=P69741 ProteinModelPortal P69741 http://www.proteinmodelportal.org/query/uniprot/P69741 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17218314 http://www.ncbi.nlm.nih.gov/pubmed/17218314 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9738917 http://www.ncbi.nlm.nih.gov/pubmed/9738917 RefSeq NP_417471 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417471 RefSeq WP_000145410 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000145410 SMR P69741 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69741 STRING 511145.b2997 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2997&targetmode=cogs STRING COG1740 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1740&targetmode=cogs TIGRFAMs TIGR00391 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00391 TIGRFAMs TIGR01409 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01409 UniProtKB MBHT_ECOLI http://www.uniprot.org/uniprot/MBHT_ECOLI UniProtKB-AC P69741 http://www.uniprot.org/uniprot/P69741 charge swissprot:MBHT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:MBHT_ECOLI eggNOG COG1740 http://eggnogapi.embl.de/nog_data/html/tree/COG1740 eggNOG ENOG4105E3S http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E3S epestfind swissprot:MBHT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:MBHT_ECOLI garnier swissprot:MBHT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:MBHT_ECOLI helixturnhelix swissprot:MBHT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:MBHT_ECOLI hmoment swissprot:MBHT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:MBHT_ECOLI iep swissprot:MBHT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:MBHT_ECOLI inforesidue swissprot:MBHT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:MBHT_ECOLI octanol swissprot:MBHT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:MBHT_ECOLI pepcoil swissprot:MBHT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:MBHT_ECOLI pepdigest swissprot:MBHT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:MBHT_ECOLI pepinfo swissprot:MBHT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:MBHT_ECOLI pepnet swissprot:MBHT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:MBHT_ECOLI pepstats swissprot:MBHT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:MBHT_ECOLI pepwheel swissprot:MBHT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:MBHT_ECOLI pepwindow swissprot:MBHT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:MBHT_ECOLI sigcleave swissprot:MBHT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:MBHT_ECOLI ## Database ID URL or Descriptions # AltName ACRE_ECOLI Acriflavine resistance protein E # AltName ACRE_ECOLI Protein EnvC # BioGrid 4261953 367 # EcoGene EG10266 acrE # FUNCTION ACRE_ECOLI Part of the tripartite efflux system AcrEF-TolC. Involved in the efflux of indole and organic solvents. {ECO 0000269|PubMed 10518736, ECO 0000269|PubMed 11274125}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0031226 intrinsic component of plasma membrane; IMP:EcoliWiki. # GO_function GO:0015238 drug transmembrane transporter activity; IBA:GO_Central. # GO_process GO:0006855 drug transmembrane transport; IBA:GO_Central. # GO_process GO:0042493 response to drug; ISS:EcoliWiki. # GO_process GO:0046677 response to antibiotic; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0008150 biological_process # GOslim_process GO:0055085 transmembrane transport # INDUCTION Induced by LeuO, part of the acrEF operon. {ECO:0000269|PubMed 19429622}. # InterPro IPR006143 RND_pump_MFP # InterPro IPR032317 HlyD_D23 # KEGG_Brite ko03036 Chromosome # Organism ACRE_ECOLI Escherichia coli (strain K12) # PATRIC 32121960 VBIEscCol129921_3364 # PIR C65119 C65119 # PROSITE PS51257 PROKAR_LIPOPROTEIN # Pfam PF00529 HlyD # Pfam PF16576 HlyD_D23 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName ACRE_ECOLI Multidrug export protein AcrE # RefSeq NP_417731 NC_000913.3 # RefSeq WP_000160334 NZ_LN832404.1 # SIMILARITY Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. {ECO 0000305}. # SUBCELLULAR LOCATION ACRE_ECOLI Cell inner membrane {ECO 0000305|PubMed 11274125}; Lipid-anchor {ECO 0000305|PubMed 11274125}. # SUBUNIT Part of the tripartite efflux system AcrEF-TolC, which is composed of an inner membrane transporter, AcrF, a periplasmic membrane fusion protein, AcrE, and an outer membrane component, TolC. The complex forms a large protein conduit and can translocate molecules across both the inner and outer membranes (Probable). {ECO:0000305|PubMed 11274125}. # TIGRFAMs TIGR01730 RND_mfp # eggNOG ENOG4105C1P Bacteria # eggNOG ENOG410XNVN LUCA BLAST swissprot:ACRE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:ACRE_ECOLI BioCyc ECOL316407:JW3233-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3233-MONOMER BioCyc EcoCyc:EG10266-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10266-MONOMER COG COG0845 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0845 DOI 10.1007/BF00290673 http://dx.doi.org/10.1007/BF00290673 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1111/j.1574-6968.1999.tb08748.x http://dx.doi.org/10.1111/j.1574-6968.1999.tb08748.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00108-09 http://dx.doi.org/10.1128/JB.00108-09 DOI 10.1128/JB.183.8.2646-2653.2001 http://dx.doi.org/10.1128/JB.183.8.2646-2653.2001 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M96848 http://www.ebi.ac.uk/ena/data/view/M96848 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X57948 http://www.ebi.ac.uk/ena/data/view/X57948 EchoBASE EB0262 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0262 EcoGene EG10266 http://www.ecogene.org/geneInfo.php?eg_id=EG10266 EnsemblBacteria AAC76297 http://www.ensemblgenomes.org/id/AAC76297 EnsemblBacteria AAC76297 http://www.ensemblgenomes.org/id/AAC76297 EnsemblBacteria BAE77306 http://www.ensemblgenomes.org/id/BAE77306 EnsemblBacteria BAE77306 http://www.ensemblgenomes.org/id/BAE77306 EnsemblBacteria BAE77306 http://www.ensemblgenomes.org/id/BAE77306 EnsemblBacteria b3265 http://www.ensemblgenomes.org/id/b3265 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0031226 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031226 GO_function GO:0015238 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015238 GO_process GO:0006855 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006855 GO_process GO:0042493 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493 GO_process GO:0046677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046677 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 947706 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947706 HOGENOM HOG000158247 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000158247&db=HOGENOM6 InParanoid P24180 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P24180 InterPro IPR006143 http://www.ebi.ac.uk/interpro/entry/IPR006143 InterPro IPR032317 http://www.ebi.ac.uk/interpro/entry/IPR032317 KEGG_Brite ko03036 http://www.genome.jp/dbget-bin/www_bget?ko03036 KEGG_Gene ecj:JW3233 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3233 KEGG_Gene eco:b3265 http://www.genome.jp/dbget-bin/www_bget?eco:b3265 KEGG_Orthology KO:K03585 http://www.genome.jp/dbget-bin/www_bget?KO:K03585 OMA QRGGDTK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QRGGDTK PROSITE PS51257 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51257 PSORT swissprot:ACRE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:ACRE_ECOLI PSORT-B swissprot:ACRE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:ACRE_ECOLI PSORT2 swissprot:ACRE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:ACRE_ECOLI Pfam PF00529 http://pfam.xfam.org/family/PF00529 Pfam PF16576 http://pfam.xfam.org/family/PF16576 Phobius swissprot:ACRE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:ACRE_ECOLI PhylomeDB P24180 http://phylomedb.org/?seqid=P24180 ProteinModelPortal P24180 http://www.proteinmodelportal.org/query/uniprot/P24180 PubMed 10518736 http://www.ncbi.nlm.nih.gov/pubmed/10518736 PubMed 11274125 http://www.ncbi.nlm.nih.gov/pubmed/11274125 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1720861 http://www.ncbi.nlm.nih.gov/pubmed/1720861 PubMed 19429622 http://www.ncbi.nlm.nih.gov/pubmed/19429622 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417731 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417731 RefSeq WP_000160334 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000160334 SMR P24180 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P24180 STRING 511145.b3265 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3265&targetmode=cogs STRING COG0845 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0845&targetmode=cogs TIGRFAMs TIGR01730 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01730 UniProtKB ACRE_ECOLI http://www.uniprot.org/uniprot/ACRE_ECOLI UniProtKB-AC P24180 http://www.uniprot.org/uniprot/P24180 charge swissprot:ACRE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:ACRE_ECOLI eggNOG ENOG4105C1P http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C1P eggNOG ENOG410XNVN http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNVN epestfind swissprot:ACRE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:ACRE_ECOLI garnier swissprot:ACRE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:ACRE_ECOLI helixturnhelix swissprot:ACRE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:ACRE_ECOLI hmoment swissprot:ACRE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:ACRE_ECOLI iep swissprot:ACRE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:ACRE_ECOLI inforesidue swissprot:ACRE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:ACRE_ECOLI octanol swissprot:ACRE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:ACRE_ECOLI pepcoil swissprot:ACRE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:ACRE_ECOLI pepdigest swissprot:ACRE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:ACRE_ECOLI pepinfo swissprot:ACRE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:ACRE_ECOLI pepnet swissprot:ACRE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:ACRE_ECOLI pepstats swissprot:ACRE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:ACRE_ECOLI pepwheel swissprot:ACRE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:ACRE_ECOLI pepwindow swissprot:ACRE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:ACRE_ECOLI sigcleave swissprot:ACRE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:ACRE_ECOLI ## Database ID URL or Descriptions # BioGrid 4262275 608 # CDD cd09646 Cas7_I-E # DISRUPTION PHENOTYPE CASC_ECOLI Loss of resistance to bacteriophage lambda infection, loss of plasmid silencing. Increased levels of 57 nucleotide crRNA and also 2 and 3 spacer-repeat units. {ECO 0000269|PubMed 18703739, ECO 0000269|PubMed 21255106, ECO 0000269|PubMed 21460843}. # EcoGene EG13117 casC # FUNCTION CASC_ECOLI A component of Cascade, which participates in CRISPR interference, the third stage of CRISPR immunity. Cascade binds both crRNA and in a sequence-specific manner negatively supercoiled dsDNA target. This leads to the formation of an R-loop in which the crRNA binds the target DNA, displacing the noncomplementary strand. Cas3 is recruited to Cascade, nicks target DNA and then unwinds and cleaves the target, leading to DNA degradation and invader neutralization. CasCDE alone is also able to form R-loops. # FUNCTION CASC_ECOLI CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). # GO_component GO:0043234 protein complex; IDA:EcoCyc. # GO_function GO:0003723 RNA binding; IDA:EcoCyc. # GO_function GO:0071667 DNA/RNA hybrid binding; IDA:EcoCyc. # GO_process GO:0051607 defense response to virus; IMP:EcoCyc. # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003723 RNA binding # GOslim_process GO:0002376 immune system process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0044403 symbiosis, encompassing mutualism through parasitism # INDUCTION CASC_ECOLI Repressed by H-NS, activated by LeuO. Activated by the BaeSR two-component regulatory system, possibly due to envelope stress. Part of the casABCDE-ygbT-ygbF operon. {ECO 0000269|PubMed 19429622, ECO 0000269|PubMed 20132443, ECO 0000269|PubMed 21255106}. # InterPro IPR010148 CRISPR-assoc_prot_CT1975 # MASS SPECTROMETRY Mass=39896.3; Mass_error=1.3; Method=Unknown; Range=2-363; Evidence={ECO:0000269|PubMed 21460843}; # Organism CASC_ECOLI Escherichia coli (strain K12) # PATRIC 32120926 VBIEscCol129921_2855 # PDB 4QYZ X-ray; 3.03 A; D/E/F/G/H/I=1-363 # PDB 4TVX X-ray; 3.24 A; B/C/D/E/F/G/N/O/P/Q/R/S=1-363 # PDB 4U7U X-ray; 3.00 A; E/F/G/H/I/J/Q/R/S/T/U/V=1-363 # PDB 5CD4 X-ray; 3.20 A; B/C/D/E/F/G/N/O/P/Q/R/S=1-363 # PDB 5H9E X-ray; 3.21 A; D/E/F/G/H/I=1-363 # PDB 5H9F X-ray; 2.45 A; D/E/F/G/H/I=1-363 # PIR B65057 B65057 # Pfam PF09344 Cas_CT1975 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CASC_ECOLI CRISPR system Cascade subunit CasC # RefSeq NP_417238 NC_000913.3 # RefSeq WP_000064450 NZ_LN832404.1 # SUBUNIT CASC_ECOLI Part of the Cascade ribonucleoprotein complex, with stoichiometry CasA(1),CasB(2),CasC(6),CasD(1),CasE(1)-crRNA(1). The 6 CasC subunits make a helical stack forming a groove in which the crRNA lies. Interacts directly with all of the Cas subunits. Stable subcomplexes of CasBCDE-crRNA and CasCDE-crRNA also form, both of which are able to bind target dsDNA, and at least CasCDE is able to form R-loops. CasCDE and CasCE complexes have endonuclease activity. Interacts with YgbT (Cas1). Binding of target ssRNA or dsDNA causes a conformational change in the Cascade complex. {ECO 0000269|PubMed 18703739, ECO 0000269|PubMed 21219465, ECO 0000269|PubMed 21255106, ECO 0000269|PubMed 21460843, ECO 0000269|PubMed 21699496, ECO 0000269|PubMed 21938068, ECO 0000269|PubMed 22521689}. # TIGRFAMs TIGR01869 casC_Cse4 # eggNOG ENOG41060M0 Bacteria # eggNOG ENOG410Y6PV LUCA BLAST swissprot:CASC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CASC_ECOLI BioCyc ECOL316407:JW2728-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2728-MONOMER BioCyc EcoCyc:G7428-MONOMER http://biocyc.org/getid?id=EcoCyc:G7428-MONOMER BioCyc MetaCyc:G7428-MONOMER http://biocyc.org/getid?id=MetaCyc:G7428-MONOMER DIP DIP-12126N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12126N DOI 10.1016/j.molcel.2012.03.018 http://dx.doi.org/10.1016/j.molcel.2012.03.018 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nature10402 http://dx.doi.org/10.1038/nature10402 DOI 10.1038/nsmb.2019 http://dx.doi.org/10.1038/nsmb.2019 DOI 10.1042/BJ20110901 http://dx.doi.org/10.1042/BJ20110901 DOI 10.1111/j.1365-2958.2010.07073.x http://dx.doi.org/10.1111/j.1365-2958.2010.07073.x DOI 10.1111/j.1365-2958.2010.07465.x http://dx.doi.org/10.1111/j.1365-2958.2010.07465.x DOI 10.1111/j.1365-2958.2010.07482.x http://dx.doi.org/10.1111/j.1365-2958.2010.07482.x DOI 10.1126/science.1159689 http://dx.doi.org/10.1126/science.1159689 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.00108-09 http://dx.doi.org/10.1128/JB.00108-09 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29579 http://www.ebi.ac.uk/ena/data/view/U29579 EchoBASE EB2918 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2918 EcoGene EG13117 http://www.ecogene.org/geneInfo.php?eg_id=EG13117 EnsemblBacteria AAC75800 http://www.ensemblgenomes.org/id/AAC75800 EnsemblBacteria AAC75800 http://www.ensemblgenomes.org/id/AAC75800 EnsemblBacteria BAE76835 http://www.ensemblgenomes.org/id/BAE76835 EnsemblBacteria BAE76835 http://www.ensemblgenomes.org/id/BAE76835 EnsemblBacteria BAE76835 http://www.ensemblgenomes.org/id/BAE76835 EnsemblBacteria b2758 http://www.ensemblgenomes.org/id/b2758 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0071667 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071667 GO_process GO:0051607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051607 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_process GO:0002376 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002376 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0044403 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044403 GeneID 947224 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947224 HOGENOM HOG000015828 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000015828&db=HOGENOM6 InParanoid Q46899 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q46899 IntAct Q46899 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q46899* InterPro IPR010148 http://www.ebi.ac.uk/interpro/entry/IPR010148 KEGG_Gene ecj:JW2728 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2728 KEGG_Gene eco:b2758 http://www.genome.jp/dbget-bin/www_bget?eco:b2758 OMA PTGKQNT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PTGKQNT PDB 4QYZ http://www.ebi.ac.uk/pdbe-srv/view/entry/4QYZ PDB 4TVX http://www.ebi.ac.uk/pdbe-srv/view/entry/4TVX PDB 4U7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U7U PDB 5CD4 http://www.ebi.ac.uk/pdbe-srv/view/entry/5CD4 PDB 5H9E http://www.ebi.ac.uk/pdbe-srv/view/entry/5H9E PDB 5H9F http://www.ebi.ac.uk/pdbe-srv/view/entry/5H9F PDBsum 4QYZ http://www.ebi.ac.uk/pdbsum/4QYZ PDBsum 4TVX http://www.ebi.ac.uk/pdbsum/4TVX PDBsum 4U7U http://www.ebi.ac.uk/pdbsum/4U7U PDBsum 5CD4 http://www.ebi.ac.uk/pdbsum/5CD4 PDBsum 5H9E http://www.ebi.ac.uk/pdbsum/5H9E PDBsum 5H9F http://www.ebi.ac.uk/pdbsum/5H9F PSORT swissprot:CASC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CASC_ECOLI PSORT-B swissprot:CASC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CASC_ECOLI PSORT2 swissprot:CASC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CASC_ECOLI Pfam PF09344 http://pfam.xfam.org/family/PF09344 Phobius swissprot:CASC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CASC_ECOLI ProteinModelPortal Q46899 http://www.proteinmodelportal.org/query/uniprot/Q46899 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18703739 http://www.ncbi.nlm.nih.gov/pubmed/18703739 PubMed 19429622 http://www.ncbi.nlm.nih.gov/pubmed/19429622 PubMed 20132443 http://www.ncbi.nlm.nih.gov/pubmed/20132443 PubMed 21219465 http://www.ncbi.nlm.nih.gov/pubmed/21219465 PubMed 21255106 http://www.ncbi.nlm.nih.gov/pubmed/21255106 PubMed 21460843 http://www.ncbi.nlm.nih.gov/pubmed/21460843 PubMed 21699496 http://www.ncbi.nlm.nih.gov/pubmed/21699496 PubMed 21938068 http://www.ncbi.nlm.nih.gov/pubmed/21938068 PubMed 22521689 http://www.ncbi.nlm.nih.gov/pubmed/22521689 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417238 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417238 RefSeq WP_000064450 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000064450 SMR Q46899 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q46899 STRING 511145.b2758 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2758&targetmode=cogs TIGRFAMs TIGR01869 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01869 UniProtKB CASC_ECOLI http://www.uniprot.org/uniprot/CASC_ECOLI UniProtKB-AC Q46899 http://www.uniprot.org/uniprot/Q46899 charge swissprot:CASC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CASC_ECOLI eggNOG ENOG41060M0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41060M0 eggNOG ENOG410Y6PV http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y6PV epestfind swissprot:CASC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CASC_ECOLI garnier swissprot:CASC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CASC_ECOLI helixturnhelix swissprot:CASC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CASC_ECOLI hmoment swissprot:CASC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CASC_ECOLI iep swissprot:CASC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CASC_ECOLI inforesidue swissprot:CASC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CASC_ECOLI octanol swissprot:CASC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CASC_ECOLI pepcoil swissprot:CASC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CASC_ECOLI pepdigest swissprot:CASC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CASC_ECOLI pepinfo swissprot:CASC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CASC_ECOLI pepnet swissprot:CASC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CASC_ECOLI pepstats swissprot:CASC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CASC_ECOLI pepwheel swissprot:CASC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CASC_ECOLI pepwindow swissprot:CASC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CASC_ECOLI sigcleave swissprot:CASC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CASC_ECOLI ## Database ID URL or Descriptions # BioGrid 4260977 18 # EcoGene EG12552 sgcR # FUNCTION SGCR_ECOLI Putative transcriptional regulator for the sgcREAQCX region. # GO_component GO:0005622 intracellular; IEA:InterPro. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; ISS:EcoCyc. # GOslim_component GO:0005622 intracellular # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # InterPro IPR001034 DeoR_HTH # InterPro IPR014036 DeoR_C # InterPro IPR018356 Tscrpt_reg_HTH_DeoR_CS # Organism SGCR_ECOLI Escherichia coli (strain K12) # PATRIC 32124186 VBIEscCol129921_4436 # PIR S56525 S56525 # PROSITE PS00894 HTH_DEOR_1 # PROSITE PS51000 HTH_DEOR_2 # Pfam PF00455 DeoRC # Pfam PF08220 HTH_DeoR # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SGCR_ECOLI Putative sgc region transcriptional regulator # RefSeq NP_418720 NC_000913.3 # RefSeq WP_000082780 NZ_LN832404.1 # SIMILARITY Contains 1 HTH deoR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00349}. # SMART SM00420 HTH_DEOR # eggNOG COG1349 LUCA # eggNOG ENOG4108PQ7 Bacteria BLAST swissprot:SGCR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SGCR_ECOLI BioCyc ECOL316407:JW4262-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4262-MONOMER BioCyc EcoCyc:G7913-MONOMER http://biocyc.org/getid?id=EcoCyc:G7913-MONOMER DIP DIP-10880N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10880N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2440 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2440 EcoGene EG12552 http://www.ecogene.org/geneInfo.php?eg_id=EG12552 EnsemblBacteria AAC77256 http://www.ensemblgenomes.org/id/AAC77256 EnsemblBacteria AAC77256 http://www.ensemblgenomes.org/id/AAC77256 EnsemblBacteria BAE78291 http://www.ensemblgenomes.org/id/BAE78291 EnsemblBacteria BAE78291 http://www.ensemblgenomes.org/id/BAE78291 EnsemblBacteria BAE78291 http://www.ensemblgenomes.org/id/BAE78291 EnsemblBacteria b4300 http://www.ensemblgenomes.org/id/b4300 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GeneID 946830 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946830 HOGENOM HOG000028629 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000028629&db=HOGENOM6 IntAct P39361 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P39361* InterPro IPR001034 http://www.ebi.ac.uk/interpro/entry/IPR001034 InterPro IPR014036 http://www.ebi.ac.uk/interpro/entry/IPR014036 InterPro IPR018356 http://www.ebi.ac.uk/interpro/entry/IPR018356 KEGG_Gene ecj:JW4262 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4262 KEGG_Gene eco:b4300 http://www.genome.jp/dbget-bin/www_bget?eco:b4300 OMA CRLIMPD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CRLIMPD PROSITE PS00894 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00894 PROSITE PS51000 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51000 PSORT swissprot:SGCR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SGCR_ECOLI PSORT-B swissprot:SGCR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SGCR_ECOLI PSORT2 swissprot:SGCR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SGCR_ECOLI Pfam PF00455 http://pfam.xfam.org/family/PF00455 Pfam PF08220 http://pfam.xfam.org/family/PF08220 Phobius swissprot:SGCR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SGCR_ECOLI PhylomeDB P39361 http://phylomedb.org/?seqid=P39361 ProteinModelPortal P39361 http://www.proteinmodelportal.org/query/uniprot/P39361 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418720 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418720 RefSeq WP_000082780 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000082780 SMART SM00420 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00420 STRING 511145.b4300 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4300&targetmode=cogs UniProtKB SGCR_ECOLI http://www.uniprot.org/uniprot/SGCR_ECOLI UniProtKB-AC P39361 http://www.uniprot.org/uniprot/P39361 charge swissprot:SGCR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SGCR_ECOLI eggNOG COG1349 http://eggnogapi.embl.de/nog_data/html/tree/COG1349 eggNOG ENOG4108PQ7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108PQ7 epestfind swissprot:SGCR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SGCR_ECOLI garnier swissprot:SGCR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SGCR_ECOLI helixturnhelix swissprot:SGCR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SGCR_ECOLI hmoment swissprot:SGCR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SGCR_ECOLI iep swissprot:SGCR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SGCR_ECOLI inforesidue swissprot:SGCR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SGCR_ECOLI octanol swissprot:SGCR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SGCR_ECOLI pepcoil swissprot:SGCR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SGCR_ECOLI pepdigest swissprot:SGCR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SGCR_ECOLI pepinfo swissprot:SGCR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SGCR_ECOLI pepnet swissprot:SGCR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SGCR_ECOLI pepstats swissprot:SGCR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SGCR_ECOLI pepwheel swissprot:SGCR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SGCR_ECOLI pepwindow swissprot:SGCR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SGCR_ECOLI sigcleave swissprot:SGCR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SGCR_ECOLI ## Database ID URL or Descriptions # AltName DNA topoisomerase III {ECO:0000255|HAMAP-Rule MF_00953} # BRENDA 5.99.1 2026 # BioGrid 4259137 56 # CATALYTIC ACTIVITY TOP3_ECOLI ATP-independent breakage of single-stranded DNA, followed by passage and rejoining. {ECO 0000255|HAMAP- Rule MF_00953, ECO 0000269|PubMed 6326814}. # CDD cd00186 TOP1Ac # COFACTOR TOP3_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_00953, ECO 0000269|PubMed 6326814}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000255|HAMAP-Rule MF_00953, ECO 0000269|PubMed 6326814}; Name=Ca(2+); Xref=ChEBI CHEBI 29108; Evidence={ECO 0000255|HAMAP-Rule MF_00953, ECO 0000269|PubMed 6326814}; Note=Binds two Mg(2+) ions per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+). {ECO 0000255|HAMAP-Rule MF_00953, ECO 0000269|PubMed 6326814}; # EcoGene EG11014 topB # FUNCTION TOP3_ECOLI Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. TOP3 is a potent decatenase. {ECO 0000255|HAMAP-Rule MF_00953, ECO 0000269|PubMed 2553698, ECO 0000269|PubMed 6326814}. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003917 DNA topoisomerase type I activity; IDA:EcoliWiki. # GO_process GO:0006265 DNA topological change; IBA:GO_Central. # GO_process GO:0006310 DNA recombination; IMP:EcoliWiki. # GO_process GO:0051304 chromosome separation; IMP:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0051276 chromosome organization # Gene3D 1.10.460.10 -; 2. # Gene3D 2.70.20.10 -; 2. # Gene3D 3.40.50.140 -; 1. # HAMAP MF_00953 Topoisom_3_prok # IntAct P14294 39 # InterPro IPR000380 Topo_IA # InterPro IPR003601 Topo_IA_2 # InterPro IPR003602 Topo_IA_DNA-bd_dom # InterPro IPR005738 TopoIII # InterPro IPR006171 Toprim_domain # InterPro IPR013497 Topo_IA_cen # InterPro IPR013824 Topo_IA_cen_sub1 # InterPro IPR013825 Topo_IA_cen_sub2 # InterPro IPR023405 Topo_IA_core_domain # InterPro IPR023406 Topo_IA_AS # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03032 DNA replication proteins # Organism TOP3_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11390 PTHR11390; 2 # PATRIC 32118837 VBIEscCol129921_1836 # PDB 1D6M X-ray; 3.00 A; A=1-653 # PDB 1I7D X-ray; 2.05 A; A=1-653 # PDB 2O19 X-ray; 2.45 A; A/B=1-653 # PDB 2O54 X-ray; 2.50 A; A/B=1-653 # PDB 2O59 X-ray; 2.50 A; A/B=1-653 # PDB 2O5C X-ray; 2.35 A; A/B=1-653 # PDB 2O5E X-ray; 2.50 A; A/B=1-653 # PIR JV0049 JV0049 # PRINTS PR00417 PRTPISMRASEI # PROSITE PS00396 TOPOISOMERASE_I_PROK # PROSITE PS50880 TOPRIM # Pfam PF01131 Topoisom_bac # Pfam PF01751 Toprim # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DNA topoisomerase 3 {ECO:0000255|HAMAP-Rule MF_00953} # RefSeq NP_416277 NC_000913.3 # RefSeq WP_001235800 NZ_LN832404.1 # SIMILARITY Belongs to the type IA topoisomerase family. {ECO:0000255|HAMAP-Rule MF_00953}. # SIMILARITY Contains 1 Toprim domain. {ECO:0000255|HAMAP- Rule MF_00953}. # SMART SM00436 TOP1Bc # SMART SM00437 TOP1Ac # SMART SM00493 TOPRIM # SUPFAM SSF56712 SSF56712 # TIGRFAMs TIGR01056 topB # eggNOG COG0550 LUCA # eggNOG ENOG4105C73 Bacteria BLAST swissprot:TOP3_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TOP3_ECOLI BioCyc ECOL316407:JW1752-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1752-MONOMER BioCyc EcoCyc:EG11014-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11014-MONOMER BioCyc MetaCyc:EG11014-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11014-MONOMER COG COG0550 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0550 DIP DIP-11012N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11012N DOI 10.1016/S0969-2126(00)80027-1 http://dx.doi.org/10.1016/S0969-2126(00)80027-1 DOI 10.1016/j.jmb.2007.01.065 http://dx.doi.org/10.1016/j.jmb.2007.01.065 DOI 10.1021/bi00304a002 http://dx.doi.org/10.1021/bi00304a002 DOI 10.1038/35082615 http://dx.doi.org/10.1038/35082615 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.99.1.2 {ECO:0000255|HAMAP-Rule:MF_00953} http://www.genome.jp/dbget-bin/www_bget?EC:5.99.1.2 {ECO:0000255|HAMAP-Rule:MF_00953} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J05076 http://www.ebi.ac.uk/ena/data/view/J05076 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 5.99.1.2 {ECO:0000255|HAMAP-Rule:MF_00953} http://enzyme.expasy.org/EC/5.99.1.2 {ECO:0000255|HAMAP-Rule:MF_00953} EchoBASE EB1007 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1007 EcoGene EG11014 http://www.ecogene.org/geneInfo.php?eg_id=EG11014 EnsemblBacteria AAC74833 http://www.ensemblgenomes.org/id/AAC74833 EnsemblBacteria AAC74833 http://www.ensemblgenomes.org/id/AAC74833 EnsemblBacteria BAA15551 http://www.ensemblgenomes.org/id/BAA15551 EnsemblBacteria BAA15551 http://www.ensemblgenomes.org/id/BAA15551 EnsemblBacteria BAA15551 http://www.ensemblgenomes.org/id/BAA15551 EnsemblBacteria b1763 http://www.ensemblgenomes.org/id/b1763 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003917 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003917 GO_process GO:0006265 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006265 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0051304 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051304 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0051276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051276 Gene3D 1.10.460.10 http://www.cathdb.info/version/latest/superfamily/1.10.460.10 Gene3D 2.70.20.10 http://www.cathdb.info/version/latest/superfamily/2.70.20.10 Gene3D 3.40.50.140 http://www.cathdb.info/version/latest/superfamily/3.40.50.140 GeneID 946141 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946141 HAMAP MF_00953 http://hamap.expasy.org/unirule/MF_00953 HOGENOM HOG000086848 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000086848&db=HOGENOM6 InParanoid P14294 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P14294 IntAct P14294 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P14294* IntEnz 5.99.1.2 {ECO:0000255|HAMAP-Rule:MF_00953} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.99.1.2 {ECO:0000255|HAMAP-Rule:MF_00953} InterPro IPR000380 http://www.ebi.ac.uk/interpro/entry/IPR000380 InterPro IPR003601 http://www.ebi.ac.uk/interpro/entry/IPR003601 InterPro IPR003602 http://www.ebi.ac.uk/interpro/entry/IPR003602 InterPro IPR005738 http://www.ebi.ac.uk/interpro/entry/IPR005738 InterPro IPR006171 http://www.ebi.ac.uk/interpro/entry/IPR006171 InterPro IPR013497 http://www.ebi.ac.uk/interpro/entry/IPR013497 InterPro IPR013824 http://www.ebi.ac.uk/interpro/entry/IPR013824 InterPro IPR013825 http://www.ebi.ac.uk/interpro/entry/IPR013825 InterPro IPR023405 http://www.ebi.ac.uk/interpro/entry/IPR023405 InterPro IPR023406 http://www.ebi.ac.uk/interpro/entry/IPR023406 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03032 http://www.genome.jp/dbget-bin/www_bget?ko03032 KEGG_Gene ecj:JW1752 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1752 KEGG_Gene eco:b1763 http://www.genome.jp/dbget-bin/www_bget?eco:b1763 KEGG_Orthology KO:K03169 http://www.genome.jp/dbget-bin/www_bget?KO:K03169 MINT MINT-1224249 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1224249 OMA RRFRGIV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RRFRGIV PANTHER PTHR11390 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11390 PDB 1D6M http://www.ebi.ac.uk/pdbe-srv/view/entry/1D6M PDB 1I7D http://www.ebi.ac.uk/pdbe-srv/view/entry/1I7D PDB 2O19 http://www.ebi.ac.uk/pdbe-srv/view/entry/2O19 PDB 2O54 http://www.ebi.ac.uk/pdbe-srv/view/entry/2O54 PDB 2O59 http://www.ebi.ac.uk/pdbe-srv/view/entry/2O59 PDB 2O5C http://www.ebi.ac.uk/pdbe-srv/view/entry/2O5C PDB 2O5E http://www.ebi.ac.uk/pdbe-srv/view/entry/2O5E PDBsum 1D6M http://www.ebi.ac.uk/pdbsum/1D6M PDBsum 1I7D http://www.ebi.ac.uk/pdbsum/1I7D PDBsum 2O19 http://www.ebi.ac.uk/pdbsum/2O19 PDBsum 2O54 http://www.ebi.ac.uk/pdbsum/2O54 PDBsum 2O59 http://www.ebi.ac.uk/pdbsum/2O59 PDBsum 2O5C http://www.ebi.ac.uk/pdbsum/2O5C PDBsum 2O5E http://www.ebi.ac.uk/pdbsum/2O5E PRINTS PR00417 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00417 PROSITE PS00396 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00396 PROSITE PS50880 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50880 PSORT swissprot:TOP3_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TOP3_ECOLI PSORT-B swissprot:TOP3_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TOP3_ECOLI PSORT2 swissprot:TOP3_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TOP3_ECOLI Pfam PF01131 http://pfam.xfam.org/family/PF01131 Pfam PF01751 http://pfam.xfam.org/family/PF01751 Phobius swissprot:TOP3_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TOP3_ECOLI PhylomeDB P14294 http://phylomedb.org/?seqid=P14294 ProteinModelPortal P14294 http://www.proteinmodelportal.org/query/uniprot/P14294 PubMed 10574789 http://www.ncbi.nlm.nih.gov/pubmed/10574789 PubMed 11429611 http://www.ncbi.nlm.nih.gov/pubmed/11429611 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17331537 http://www.ncbi.nlm.nih.gov/pubmed/17331537 PubMed 2553698 http://www.ncbi.nlm.nih.gov/pubmed/2553698 PubMed 6326814 http://www.ncbi.nlm.nih.gov/pubmed/6326814 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416277 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416277 RefSeq WP_001235800 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001235800 SMART SM00436 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00436 SMART SM00437 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00437 SMART SM00493 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00493 SMR P14294 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P14294 STRING 511145.b1763 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1763&targetmode=cogs STRING COG0550 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0550&targetmode=cogs SUPFAM SSF56712 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56712 TIGRFAMs TIGR01056 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01056 UniProtKB TOP3_ECOLI http://www.uniprot.org/uniprot/TOP3_ECOLI UniProtKB-AC P14294 http://www.uniprot.org/uniprot/P14294 charge swissprot:TOP3_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TOP3_ECOLI eggNOG COG0550 http://eggnogapi.embl.de/nog_data/html/tree/COG0550 eggNOG ENOG4105C73 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C73 epestfind swissprot:TOP3_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TOP3_ECOLI garnier swissprot:TOP3_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TOP3_ECOLI helixturnhelix swissprot:TOP3_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TOP3_ECOLI hmoment swissprot:TOP3_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TOP3_ECOLI iep swissprot:TOP3_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TOP3_ECOLI inforesidue swissprot:TOP3_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TOP3_ECOLI octanol swissprot:TOP3_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TOP3_ECOLI pepcoil swissprot:TOP3_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TOP3_ECOLI pepdigest swissprot:TOP3_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TOP3_ECOLI pepinfo swissprot:TOP3_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TOP3_ECOLI pepnet swissprot:TOP3_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TOP3_ECOLI pepstats swissprot:TOP3_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TOP3_ECOLI pepwheel swissprot:TOP3_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TOP3_ECOLI pepwindow swissprot:TOP3_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TOP3_ECOLI sigcleave swissprot:TOP3_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TOP3_ECOLI ## Database ID URL or Descriptions # AltName YFIL_ECOLI URF2 # BioGrid 4260650 204 # EcoGene EG12446 yfiL # InterPro IPR021242 DUF2799 # Organism YFIL_ECOLI Escherichia coli (strain K12) # PATRIC 32120603 VBIEscCol129921_2700 # PIR E65038 QQEC89 # Pfam PF10973 DUF2799 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFIL_ECOLI Uncharacterized protein YfiL # RefSeq NP_417093 NC_000913.3 # RefSeq WP_000976004 NZ_LN832404.1 # eggNOG ENOG4105QP9 Bacteria # eggNOG ENOG4111Z38 LUCA BLAST swissprot:YFIL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFIL_ECOLI BioCyc ECOL316407:JW5412-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5412-MONOMER BioCyc EcoCyc:EG12446-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12446-MONOMER DOI 10.1016/0022-2836(84)90269-9 http://dx.doi.org/10.1016/0022-2836(84)90269-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M10431 http://www.ebi.ac.uk/ena/data/view/M10431 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2340 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2340 EcoGene EG12446 http://www.ecogene.org/geneInfo.php?eg_id=EG12446 EnsemblBacteria AAC75651 http://www.ensemblgenomes.org/id/AAC75651 EnsemblBacteria AAC75651 http://www.ensemblgenomes.org/id/AAC75651 EnsemblBacteria BAA16488 http://www.ensemblgenomes.org/id/BAA16488 EnsemblBacteria BAA16488 http://www.ensemblgenomes.org/id/BAA16488 EnsemblBacteria BAA16488 http://www.ensemblgenomes.org/id/BAA16488 EnsemblBacteria b2602 http://www.ensemblgenomes.org/id/b2602 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947106 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947106 HOGENOM HOG000123547 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000123547&db=HOGENOM6 InterPro IPR021242 http://www.ebi.ac.uk/interpro/entry/IPR021242 KEGG_Gene ecj:JW5412 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5412 KEGG_Gene eco:b2602 http://www.genome.jp/dbget-bin/www_bget?eco:b2602 OMA KEDAMNG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KEDAMNG PSORT swissprot:YFIL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFIL_ECOLI PSORT-B swissprot:YFIL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFIL_ECOLI PSORT2 swissprot:YFIL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFIL_ECOLI Pfam PF10973 http://pfam.xfam.org/family/PF10973 Phobius swissprot:YFIL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFIL_ECOLI ProteinModelPortal P11289 http://www.proteinmodelportal.org/query/uniprot/P11289 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 6396419 http://www.ncbi.nlm.nih.gov/pubmed/6396419 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417093 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417093 RefSeq WP_000976004 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000976004 STRING 511145.b2602 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2602&targetmode=cogs UniProtKB YFIL_ECOLI http://www.uniprot.org/uniprot/YFIL_ECOLI UniProtKB-AC P11289 http://www.uniprot.org/uniprot/P11289 charge swissprot:YFIL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFIL_ECOLI eggNOG ENOG4105QP9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105QP9 eggNOG ENOG4111Z38 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111Z38 epestfind swissprot:YFIL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFIL_ECOLI garnier swissprot:YFIL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFIL_ECOLI helixturnhelix swissprot:YFIL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFIL_ECOLI hmoment swissprot:YFIL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFIL_ECOLI iep swissprot:YFIL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFIL_ECOLI inforesidue swissprot:YFIL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFIL_ECOLI octanol swissprot:YFIL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFIL_ECOLI pepcoil swissprot:YFIL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFIL_ECOLI pepdigest swissprot:YFIL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFIL_ECOLI pepinfo swissprot:YFIL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFIL_ECOLI pepnet swissprot:YFIL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFIL_ECOLI pepstats swissprot:YFIL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFIL_ECOLI pepwheel swissprot:YFIL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFIL_ECOLI pepwindow swissprot:YFIL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFIL_ECOLI sigcleave swissprot:YFIL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFIL_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES pH dependence: Optimum pH is 7.5 for the truncated enzyme. {ECO 0000269|PubMed:20522491}; # BioGrid 4260585 23 # CATALYTIC ACTIVITY YFGF_ECOLI Cyclic di-3',5'-guanylate + H(2)O = 5'- phosphoguanylyl(3'->5')guanosine. # CDD cd01948 EAL # COFACTOR YFGF_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 20522491}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 20522491}; Note=Mg(2+), and possibly also Mn(2+). {ECO 0000269|PubMed 20522491}; # DISRUPTION PHENOTYPE Increased biofilm formation but a decreased tendency to sediment and aggregate. Cells are more sensitive to peroxide. {ECO:0000269|PubMed 20522491}. # ENZYME REGULATION Inhibited by pGpG. {ECO:0000269|PubMed 20522491}. # EcoGene EG14202 yfgF # FUNCTION YFGF_ECOLI Truncated proteins consisting of the GGDEF/EAL domains (residues 319-747) or of the EAL domain alone (481-747) have c-di- GMP phosphodiesterase activity. They do not have diguanylate cyclase activity. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria. {ECO 0000269|PubMed 20522491}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IDA:EcoCyc. # GO_function GO:0000166 nucleotide binding; IEA:UniProtKB-KW. # GO_function GO:0071111 cyclic-guanylate-specific phosphodiesterase activity; IDA:EcoCyc. # GO_process GO:0070301 cellular response to hydrogen peroxide; IMP:EcoCyc. # GO_process GO:0071454 cellular response to anoxia; IMP:EcoCyc. # GO_process GO:1900190 regulation of single-species biofilm formation; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # Gene3D 3.20.20.450 -; 1. # INDUCTION Induced by FNR. Expression is highest under anaerobic conditions at 28 degrees Celsius in stationary phase. {ECO:0000269|PubMed 20522491}. # InterPro IPR000160 GGDEF_dom # InterPro IPR001633 EAL_dom # InterPro IPR007895 MASE1 # Organism YFGF_ECOLI Escherichia coli (strain K12) # PATRIC 32120395 VBIEscCol129921_2600 # PIR F65026 F65026 # PROSITE PS50883 EAL # Pfam PF00563 EAL # Pfam PF05231 MASE1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFGF_ECOLI Cyclic di-GMP phosphodiesterase YfgF # RefSeq NP_416998 NC_000913.3 # RefSeq WP_000772731 NZ_LN832404.1 # SIMILARITY Contains 1 EAL domain. {ECO:0000255|PROSITE- ProRule PRU00074}. # SMART SM00052 EAL # SMART SM00267 GGDEF # SUBCELLULAR LOCATION YFGF_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF141868 SSF141868 # eggNOG ENOG4105BZU Bacteria # eggNOG ENOG410XNMH LUCA BLAST swissprot:YFGF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFGF_ECOLI BioCyc ECOL316407:JW2488-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2488-MONOMER BioCyc EcoCyc:G7314-MONOMER http://biocyc.org/getid?id=EcoCyc:G7314-MONOMER BioCyc MetaCyc:G7314-MONOMER http://biocyc.org/getid?id=MetaCyc:G7314-MONOMER DIP DIP-12038N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12038N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1099/mic.0.037887-0 http://dx.doi.org/10.1099/mic.0.037887-0 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.4.52 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.4.52 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.4.52 http://enzyme.expasy.org/EC/3.1.4.52 EchoBASE EB3954 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3954 EcoGene EG14202 http://www.ecogene.org/geneInfo.php?eg_id=EG14202 EnsemblBacteria AAC75556 http://www.ensemblgenomes.org/id/AAC75556 EnsemblBacteria AAC75556 http://www.ensemblgenomes.org/id/AAC75556 EnsemblBacteria BAA16393 http://www.ensemblgenomes.org/id/BAA16393 EnsemblBacteria BAA16393 http://www.ensemblgenomes.org/id/BAA16393 EnsemblBacteria BAA16393 http://www.ensemblgenomes.org/id/BAA16393 EnsemblBacteria b2503 http://www.ensemblgenomes.org/id/b2503 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0000166 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000166 GO_function GO:0071111 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071111 GO_process GO:0070301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070301 GO_process GO:0071454 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071454 GO_process GO:1900190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1900190 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 Gene3D 3.20.20.450 http://www.cathdb.info/version/latest/superfamily/3.20.20.450 GeneID 946968 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946968 HOGENOM HOG000123041 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000123041&db=HOGENOM6 InParanoid P77172 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77172 IntAct P77172 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77172* IntEnz 3.1.4.52 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.4.52 InterPro IPR000160 http://www.ebi.ac.uk/interpro/entry/IPR000160 InterPro IPR001633 http://www.ebi.ac.uk/interpro/entry/IPR001633 InterPro IPR007895 http://www.ebi.ac.uk/interpro/entry/IPR007895 KEGG_Gene ecj:JW2488 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2488 KEGG_Gene eco:b2503 http://www.genome.jp/dbget-bin/www_bget?eco:b2503 OMA FRLIWNG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FRLIWNG PROSITE PS50883 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50883 PSORT swissprot:YFGF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFGF_ECOLI PSORT-B swissprot:YFGF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFGF_ECOLI PSORT2 swissprot:YFGF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFGF_ECOLI Pfam PF00563 http://pfam.xfam.org/family/PF00563 Pfam PF05231 http://pfam.xfam.org/family/PF05231 Phobius swissprot:YFGF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFGF_ECOLI PhylomeDB P77172 http://phylomedb.org/?seqid=P77172 ProteinModelPortal P77172 http://www.proteinmodelportal.org/query/uniprot/P77172 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20522491 http://www.ncbi.nlm.nih.gov/pubmed/20522491 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416998 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416998 RefSeq WP_000772731 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000772731 SMART SM00052 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00052 SMART SM00267 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00267 SMR P77172 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77172 STRING 511145.b2503 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2503&targetmode=cogs SUPFAM SSF141868 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF141868 UniProtKB YFGF_ECOLI http://www.uniprot.org/uniprot/YFGF_ECOLI UniProtKB-AC P77172 http://www.uniprot.org/uniprot/P77172 charge swissprot:YFGF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFGF_ECOLI eggNOG ENOG4105BZU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZU eggNOG ENOG410XNMH http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNMH epestfind swissprot:YFGF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFGF_ECOLI garnier swissprot:YFGF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFGF_ECOLI helixturnhelix swissprot:YFGF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFGF_ECOLI hmoment swissprot:YFGF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFGF_ECOLI iep swissprot:YFGF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFGF_ECOLI inforesidue swissprot:YFGF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFGF_ECOLI octanol swissprot:YFGF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFGF_ECOLI pepcoil swissprot:YFGF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFGF_ECOLI pepdigest swissprot:YFGF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFGF_ECOLI pepinfo swissprot:YFGF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFGF_ECOLI pepnet swissprot:YFGF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFGF_ECOLI pepstats swissprot:YFGF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFGF_ECOLI pepwheel swissprot:YFGF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFGF_ECOLI pepwindow swissprot:YFGF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFGF_ECOLI sigcleave swissprot:YFGF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFGF_ECOLI ## Database ID URL or Descriptions # BioGrid 4260629 12 # CAUTION PubMed:1849680 sequence is supposed to originate from Cercopithecus aethiops, but this is clearly a case of bacterial contamination from E.coli. {ECO 0000305}. # EcoGene EG13206 yfjT # Organism YFJT_ECOLI Escherichia coli (strain K12) # PATRIC 32120665 VBIEscCol129921_2731 # PIR T08648 T08648 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFJT_ECOLI Uncharacterized protein YfjT # RefSeq NP_417125 NC_000913.3 # RefSeq WP_000702495 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA35359.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY To E.coli YkfB. {ECO 0000305}. # eggNOG ENOG4106J9S Bacteria # eggNOG ENOG410Y9JJ LUCA BLAST swissprot:YFJT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFJT_ECOLI BioCyc ECOL316407:JW2618-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2618-MONOMER BioCyc EcoCyc:G7372-MONOMER http://biocyc.org/getid?id=EcoCyc:G7372-MONOMER DOI 10.1016/0042-6822(91)90895-I http://dx.doi.org/10.1016/0042-6822(91)90895-I DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M59434 http://www.ebi.ac.uk/ena/data/view/M59434 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36840 http://www.ebi.ac.uk/ena/data/view/U36840 EchoBASE EB2998 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2998 EcoGene EG13206 http://www.ecogene.org/geneInfo.php?eg_id=EG13206 EnsemblBacteria AAC75685 http://www.ensemblgenomes.org/id/AAC75685 EnsemblBacteria AAC75685 http://www.ensemblgenomes.org/id/AAC75685 EnsemblBacteria BAE76772 http://www.ensemblgenomes.org/id/BAE76772 EnsemblBacteria BAE76772 http://www.ensemblgenomes.org/id/BAE76772 EnsemblBacteria BAE76772 http://www.ensemblgenomes.org/id/BAE76772 EnsemblBacteria b2637 http://www.ensemblgenomes.org/id/b2637 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947616 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947616 HOGENOM HOG000001687 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000001687&db=HOGENOM6 KEGG_Gene ecj:JW2618 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2618 KEGG_Gene eco:b2637 http://www.genome.jp/dbget-bin/www_bget?eco:b2637 OMA TAQAIPN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TAQAIPN PSORT swissprot:YFJT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFJT_ECOLI PSORT-B swissprot:YFJT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFJT_ECOLI PSORT2 swissprot:YFJT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFJT_ECOLI Phobius swissprot:YFJT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFJT_ECOLI ProteinModelPortal P52135 http://www.proteinmodelportal.org/query/uniprot/P52135 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1849680 http://www.ncbi.nlm.nih.gov/pubmed/1849680 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417125 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417125 RefSeq WP_000702495 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000702495 STRING 511145.b2637 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2637&targetmode=cogs UniProtKB YFJT_ECOLI http://www.uniprot.org/uniprot/YFJT_ECOLI UniProtKB-AC P52135 http://www.uniprot.org/uniprot/P52135 charge swissprot:YFJT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFJT_ECOLI eggNOG ENOG4106J9S http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106J9S eggNOG ENOG410Y9JJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Y9JJ epestfind swissprot:YFJT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFJT_ECOLI garnier swissprot:YFJT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFJT_ECOLI helixturnhelix swissprot:YFJT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFJT_ECOLI hmoment swissprot:YFJT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFJT_ECOLI iep swissprot:YFJT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFJT_ECOLI inforesidue swissprot:YFJT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFJT_ECOLI octanol swissprot:YFJT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFJT_ECOLI pepcoil swissprot:YFJT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFJT_ECOLI pepdigest swissprot:YFJT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFJT_ECOLI pepinfo swissprot:YFJT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFJT_ECOLI pepnet swissprot:YFJT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFJT_ECOLI pepstats swissprot:YFJT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFJT_ECOLI pepwheel swissprot:YFJT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFJT_ECOLI pepwindow swissprot:YFJT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFJT_ECOLI sigcleave swissprot:YFJT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFJT_ECOLI ## Database ID URL or Descriptions # BioGrid 4259986 11 # CATALYTIC ACTIVITY YLIE_ECOLI Cyclic di-3',5'-guanylate + H(2)O = 5'- phosphoguanylyl(3'->5')guanosine. # CDD cd01948 EAL # DISRUPTION PHENOTYPE Cells lacking this gene have a weak reduction in swarm size. {ECO:0000269|PubMed 20303158}. # EcoGene EG13476 yliE # FUNCTION YLIE_ECOLI Overexpression reduces biofilm formation. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria. {ECO 0000269|PubMed 19460094}. # GO_function GO:0071111 cyclic-guanylate-specific phosphodiesterase activity; IEA:UniProtKB-EC. # GOslim_function GO:0003674 molecular_function # Gene3D 3.20.20.450 -; 1. # InterPro IPR001633 EAL_dom # InterPro IPR033418 CHASE9 # Organism YLIE_ECOLI Escherichia coli (strain K12) # PATRIC 32116869 VBIEscCol129921_0860 # PIR A64821 A64821 # PROSITE PS50883 EAL # Pfam PF00563 EAL # Pfam PF17153 CHASE9 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YLIE_ECOLI Putative cyclic di-GMP phosphodiesterase YliE # RefSeq NP_415354 NC_000913.3 # RefSeq WP_001360263 NZ_LN832404.1 # SIMILARITY Contains 1 EAL domain. {ECO:0000255|PROSITE- ProRule PRU00074}. # SMART SM00052 EAL # SUPFAM SSF141868 SSF141868 # eggNOG ENOG4105BZU Bacteria # eggNOG ENOG410XNMH LUCA BLAST swissprot:YLIE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YLIE_ECOLI BioCyc ECOL316407:JW0817-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0817-MONOMER BioCyc EcoCyc:G6433-MONOMER http://biocyc.org/getid?id=EcoCyc:G6433-MONOMER DOI 10.1016/j.cell.2010.01.018 http://dx.doi.org/10.1016/j.cell.2010.01.018 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.2009.06739.x http://dx.doi.org/10.1111/j.1365-2958.2009.06739.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.4.52 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.4.52 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.4.52 http://enzyme.expasy.org/EC/3.1.4.52 EchoBASE EB3249 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3249 EcoGene EG13476 http://www.ecogene.org/geneInfo.php?eg_id=EG13476 EnsemblBacteria AAC73920 http://www.ensemblgenomes.org/id/AAC73920 EnsemblBacteria AAC73920 http://www.ensemblgenomes.org/id/AAC73920 EnsemblBacteria BAA35528 http://www.ensemblgenomes.org/id/BAA35528 EnsemblBacteria BAA35528 http://www.ensemblgenomes.org/id/BAA35528 EnsemblBacteria BAA35528 http://www.ensemblgenomes.org/id/BAA35528 EnsemblBacteria b0833 http://www.ensemblgenomes.org/id/b0833 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0071111 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071111 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 Gene3D 3.20.20.450 http://www.cathdb.info/version/latest/superfamily/3.20.20.450 GeneID 945462 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945462 HOGENOM HOG000118172 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118172&db=HOGENOM6 IntEnz 3.1.4.52 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.4.52 InterPro IPR001633 http://www.ebi.ac.uk/interpro/entry/IPR001633 InterPro IPR033418 http://www.ebi.ac.uk/interpro/entry/IPR033418 KEGG_Gene ecj:JW0817 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0817 KEGG_Gene eco:b0833 http://www.genome.jp/dbget-bin/www_bget?eco:b0833 OMA GFLLHIN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GFLLHIN PROSITE PS50883 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50883 PSORT swissprot:YLIE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YLIE_ECOLI PSORT-B swissprot:YLIE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YLIE_ECOLI PSORT2 swissprot:YLIE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YLIE_ECOLI Pfam PF00563 http://pfam.xfam.org/family/PF00563 Pfam PF17153 http://pfam.xfam.org/family/PF17153 Phobius swissprot:YLIE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YLIE_ECOLI PhylomeDB P75800 http://phylomedb.org/?seqid=P75800 ProteinModelPortal P75800 http://www.proteinmodelportal.org/query/uniprot/P75800 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19460094 http://www.ncbi.nlm.nih.gov/pubmed/19460094 PubMed 20303158 http://www.ncbi.nlm.nih.gov/pubmed/20303158 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415354 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415354 RefSeq WP_001360263 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001360263 SMART SM00052 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00052 SMR P75800 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75800 STRING 511145.b0833 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0833&targetmode=cogs SUPFAM SSF141868 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF141868 UniProtKB YLIE_ECOLI http://www.uniprot.org/uniprot/YLIE_ECOLI UniProtKB-AC P75800 http://www.uniprot.org/uniprot/P75800 charge swissprot:YLIE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YLIE_ECOLI eggNOG ENOG4105BZU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105BZU eggNOG ENOG410XNMH http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNMH epestfind swissprot:YLIE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YLIE_ECOLI garnier swissprot:YLIE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YLIE_ECOLI helixturnhelix swissprot:YLIE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YLIE_ECOLI hmoment swissprot:YLIE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YLIE_ECOLI iep swissprot:YLIE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YLIE_ECOLI inforesidue swissprot:YLIE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YLIE_ECOLI octanol swissprot:YLIE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YLIE_ECOLI pepcoil swissprot:YLIE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YLIE_ECOLI pepdigest swissprot:YLIE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YLIE_ECOLI pepinfo swissprot:YLIE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YLIE_ECOLI pepnet swissprot:YLIE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YLIE_ECOLI pepstats swissprot:YLIE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YLIE_ECOLI pepwheel swissprot:YLIE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YLIE_ECOLI pepwindow swissprot:YLIE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YLIE_ECOLI sigcleave swissprot:YLIE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YLIE_ECOLI ## Database ID URL or Descriptions # AltName Fructose-like phosphotransferase enzyme IIB component 1 {ECO:0000250|UniProtKB P20966} # BioGrid 4260782 10 # CATALYTIC ACTIVITY [Protein]-N(pi)-phospho-L-histidine + D- fructose(Side 1) = [protein]-L-histidine + D-fructose 1- phosphate(Side 2). {ECO:0000250|UniProtKB P20966}. # CDD cd05569 PTS_IIB_fructose # DOMAIN PTFB1_ECOLI The PTS EIIB type-2 domain is phosphorylated by phospho- EIIA on a cysteinyl residue. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the PTS EIIC type-2 domain. {ECO 0000255|PROSITE- ProRule PRU00422}. # EcoGene EG14155 fryB # FUNCTION PTFB1_ECOLI The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FryABC PTS system is involved in fructose transport. {ECO 0000250|UniProtKB P20966}. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0016301 kinase activity; IEA:UniProtKB-KW. # GO_function GO:0022877 protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity; IEA:InterPro. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # InterPro IPR003353 PTS_IIB_fruc # InterPro IPR003501 PTS_EIIB_2/3 # InterPro IPR013011 PTS_EIIB_2 # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00306 PTS system, fructose-specific II-like component # KEGG_Brite ko02000 Transporters # Organism PTFB1_ECOLI Escherichia coli (strain K12) # PATRIC 32120153 VBIEscCol129921_2485 # PDB 2KYR NMR; -; A=1-108 # PIR H65012 H65012 # PROSITE PS51099 PTS_EIIB_TYPE_2 # Pfam PF02302 PTS_IIB # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PTS system fructose-like EIIB component 1 {ECO:0000250|UniProtKB P20966} # RefSeq NP_416888 NC_000913.3 # RefSeq WP_000038456 NZ_LN832404.1 # SIMILARITY Contains 1 PTS EIIB type-2 domain. {ECO:0000255|PROSITE-ProRule PRU00422}. # SUBCELLULAR LOCATION PTFB1_ECOLI Cytoplasm {ECO 0000305}. # SUPFAM SSF52794 SSF52794 # TCDB 4.A.2.1.11 the pts fructose-mannitol (fru) family # TIGRFAMs TIGR00829 FRU # eggNOG COG1445 LUCA # eggNOG ENOG4105R6B Bacteria BLAST swissprot:PTFB1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTFB1_ECOLI BioCyc ECOL316407:JW5389-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5389-MONOMER BioCyc EcoCyc:G7250-MONOMER http://biocyc.org/getid?id=EcoCyc:G7250-MONOMER COG COG1445 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1445 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.1.202 {ECO:0000250|UniProtKB:P20966} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.1.202 {ECO:0000250|UniProtKB:P20966} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.1.202 {ECO:0000250|UniProtKB:P20966} http://enzyme.expasy.org/EC/2.7.1.202 {ECO:0000250|UniProtKB:P20966} EchoBASE EB3907 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3907 EcoGene EG14155 http://www.ecogene.org/geneInfo.php?eg_id=EG14155 EnsemblBacteria AAC75446 http://www.ensemblgenomes.org/id/AAC75446 EnsemblBacteria AAC75446 http://www.ensemblgenomes.org/id/AAC75446 EnsemblBacteria BAA16257 http://www.ensemblgenomes.org/id/BAA16257 EnsemblBacteria BAA16257 http://www.ensemblgenomes.org/id/BAA16257 EnsemblBacteria BAA16257 http://www.ensemblgenomes.org/id/BAA16257 EnsemblBacteria b2387 http://www.ensemblgenomes.org/id/b2387 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_function GO:0022877 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022877 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 949087 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949087 HOGENOM HOG000231313 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000231313&db=HOGENOM6 IntEnz 2.7.1.202 {ECO:0000250|UniProtKB:P20966} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.1.202 {ECO:0000250|UniProtKB:P20966} InterPro IPR003353 http://www.ebi.ac.uk/interpro/entry/IPR003353 InterPro IPR003501 http://www.ebi.ac.uk/interpro/entry/IPR003501 InterPro IPR013011 http://www.ebi.ac.uk/interpro/entry/IPR013011 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5389 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5389 KEGG_Gene eco:b2387 http://www.genome.jp/dbget-bin/www_bget?eco:b2387 KEGG_Orthology KO:K11202 http://www.genome.jp/dbget-bin/www_bget?KO:K11202 OMA DNERFAT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DNERFAT PDB 2KYR http://www.ebi.ac.uk/pdbe-srv/view/entry/2KYR PDBsum 2KYR http://www.ebi.ac.uk/pdbsum/2KYR PROSITE PS51099 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51099 PSORT swissprot:PTFB1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTFB1_ECOLI PSORT-B swissprot:PTFB1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTFB1_ECOLI PSORT2 swissprot:PTFB1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTFB1_ECOLI Pfam PF02302 http://pfam.xfam.org/family/PF02302 Phobius swissprot:PTFB1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTFB1_ECOLI PhylomeDB P69808 http://phylomedb.org/?seqid=P69808 ProteinModelPortal P69808 http://www.proteinmodelportal.org/query/uniprot/P69808 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416888 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416888 RefSeq WP_000038456 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000038456 SMR P69808 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69808 STRING 511145.b2387 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2387&targetmode=cogs STRING COG1445 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1445&targetmode=cogs SUPFAM SSF52794 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52794 TCDB 4.A.2.1.11 http://www.tcdb.org/search/result.php?tc=4.A.2.1.11 TIGRFAMs TIGR00829 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00829 UniProtKB PTFB1_ECOLI http://www.uniprot.org/uniprot/PTFB1_ECOLI UniProtKB-AC P69808 http://www.uniprot.org/uniprot/P69808 charge swissprot:PTFB1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTFB1_ECOLI eggNOG COG1445 http://eggnogapi.embl.de/nog_data/html/tree/COG1445 eggNOG ENOG4105R6B http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105R6B epestfind swissprot:PTFB1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTFB1_ECOLI garnier swissprot:PTFB1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTFB1_ECOLI helixturnhelix swissprot:PTFB1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTFB1_ECOLI hmoment swissprot:PTFB1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTFB1_ECOLI iep swissprot:PTFB1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTFB1_ECOLI inforesidue swissprot:PTFB1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTFB1_ECOLI octanol swissprot:PTFB1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTFB1_ECOLI pepcoil swissprot:PTFB1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTFB1_ECOLI pepdigest swissprot:PTFB1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTFB1_ECOLI pepinfo swissprot:PTFB1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTFB1_ECOLI pepnet swissprot:PTFB1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTFB1_ECOLI pepstats swissprot:PTFB1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTFB1_ECOLI pepwheel swissprot:PTFB1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTFB1_ECOLI pepwindow swissprot:PTFB1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTFB1_ECOLI sigcleave swissprot:PTFB1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTFB1_ECOLI ## Database ID URL or Descriptions # AltName RSMH_ECOLI 16S rRNA m(4)C1402 methyltransferase # AltName RSMH_ECOLI rRNA (cytosine-N(4)-)-methyltransferase RsmH # BRENDA 2.1.1.199 2026 # BioGrid 4261639 12 # CATALYTIC ACTIVITY S-adenosyl-L-methionine + cytosine(1402) in 16S rRNA = S-adenosyl-L-homocysteine + N(4)-methylcytosine(1402) in 16S rRNA. {ECO:0000269|PubMed 19965768}. # EcoGene EG11085 rsmH # FUNCTION RSMH_ECOLI Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. In vitro, active on the assembled 30S subunit, but not naked 16S rRNA or 70S ribosomes. {ECO 0000269|PubMed 10572301, ECO 0000269|PubMed 19965768}. # GO_component GO:0005737 cytoplasm; IDA:EcoCyc. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0071424 rRNA (cytosine-N4-)-methyltransferase activity; IDA:EcoCyc. # GO_process GO:0070475 rRNA base methylation; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.150.170 -; 1. # Gene3D 3.40.50.150 -; 2. # HAMAP MF_01007 16SrRNA_methyltr_H # IntAct P60390 6 # InterPro IPR002903 RsmH # InterPro IPR023397 SAM-dep_MeTrfase_MraW_recog # InterPro IPR029063 SAM-dependent_MTases # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # Organism RSMH_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11265 PTHR11265 # PATRIC 32115269 VBIEscCol129921_0086 # PDB 3TKA X-ray; 2.25 A; A=1-313 # PIR JH0092 QQECFT # PIRSF PIRSF004486 MraW # Pfam PF01795 Methyltransf_5 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RSMH_ECOLI Ribosomal RNA small subunit methyltransferase H # RefSeq NP_414624 NC_000913.3 # RefSeq WP_000970479 NZ_LN832404.1 # SIMILARITY Belongs to the methyltransferase superfamily. RsmH family. {ECO 0000305}. # SUBCELLULAR LOCATION RSMH_ECOLI Cytoplasm {ECO 0000269|PubMed 10572301}. # SUPFAM SSF53335 SSF53335; 2 # SUPFAM SSF81799 SSF81799 # TIGRFAMs TIGR00006 TIGR00006 # eggNOG COG0275 LUCA # eggNOG ENOG4105CGJ Bacteria BLAST swissprot:RSMH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RSMH_ECOLI BioCyc ECOL316407:JW0080-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0080-MONOMER BioCyc EcoCyc:EG11085-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11085-MONOMER BioCyc MetaCyc:EG11085-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11085-MONOMER COG COG0275 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0275 DIP DIP-35840N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35840N DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1007/BF00330881 http://dx.doi.org/10.1007/BF00330881 DOI 10.1016/S0300-9084(99)00208-4 http://dx.doi.org/10.1016/S0300-9084(99)00208-4 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/18.9.2813 http://dx.doi.org/10.1093/nar/18.9.2813 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1093/nar/gkp1073 http://dx.doi.org/10.1093/nar/gkp1073 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.1.199 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.199 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K00137 http://www.ebi.ac.uk/ena/data/view/K00137 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X52063 http://www.ebi.ac.uk/ena/data/view/X52063 EMBL X55034 http://www.ebi.ac.uk/ena/data/view/X55034 ENZYME 2.1.1.199 http://enzyme.expasy.org/EC/2.1.1.199 EchoBASE EB1077 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1077 EcoGene EG11085 http://www.ecogene.org/geneInfo.php?eg_id=EG11085 EnsemblBacteria AAC73193 http://www.ensemblgenomes.org/id/AAC73193 EnsemblBacteria AAC73193 http://www.ensemblgenomes.org/id/AAC73193 EnsemblBacteria BAB96650 http://www.ensemblgenomes.org/id/BAB96650 EnsemblBacteria BAB96650 http://www.ensemblgenomes.org/id/BAB96650 EnsemblBacteria BAB96650 http://www.ensemblgenomes.org/id/BAB96650 EnsemblBacteria b0082 http://www.ensemblgenomes.org/id/b0082 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0071424 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071424 GO_process GO:0070475 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070475 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.150.170 http://www.cathdb.info/version/latest/superfamily/1.10.150.170 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 GeneID 944806 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944806 HAMAP MF_01007 http://hamap.expasy.org/unirule/MF_01007 HOGENOM HOG000049778 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000049778&db=HOGENOM6 InParanoid P60390 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P60390 IntAct P60390 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P60390* IntEnz 2.1.1.199 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.199 InterPro IPR002903 http://www.ebi.ac.uk/interpro/entry/IPR002903 InterPro IPR023397 http://www.ebi.ac.uk/interpro/entry/IPR023397 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW0080 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0080 KEGG_Gene eco:b0082 http://www.genome.jp/dbget-bin/www_bget?eco:b0082 KEGG_Orthology KO:K03438 http://www.genome.jp/dbget-bin/www_bget?KO:K03438 OMA ADGCYLD http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ADGCYLD PANTHER PTHR11265 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11265 PDB 3TKA http://www.ebi.ac.uk/pdbe-srv/view/entry/3TKA PDBsum 3TKA http://www.ebi.ac.uk/pdbsum/3TKA PSORT swissprot:RSMH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RSMH_ECOLI PSORT-B swissprot:RSMH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RSMH_ECOLI PSORT2 swissprot:RSMH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RSMH_ECOLI Pfam PF01795 http://pfam.xfam.org/family/PF01795 Phobius swissprot:RSMH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RSMH_ECOLI PhylomeDB P60390 http://phylomedb.org/?seqid=P60390 ProteinModelPortal P60390 http://www.proteinmodelportal.org/query/uniprot/P60390 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 10572301 http://www.ncbi.nlm.nih.gov/pubmed/10572301 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19965768 http://www.ncbi.nlm.nih.gov/pubmed/19965768 PubMed 2187182 http://www.ncbi.nlm.nih.gov/pubmed/2187182 PubMed 6350821 http://www.ncbi.nlm.nih.gov/pubmed/6350821 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414624 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414624 RefSeq WP_000970479 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000970479 SMR P60390 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P60390 STRING 511145.b0082 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0082&targetmode=cogs STRING COG0275 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0275&targetmode=cogs SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 SUPFAM SSF81799 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF81799 TIGRFAMs TIGR00006 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00006 UniProtKB RSMH_ECOLI http://www.uniprot.org/uniprot/RSMH_ECOLI UniProtKB-AC P60390 http://www.uniprot.org/uniprot/P60390 charge swissprot:RSMH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RSMH_ECOLI eggNOG COG0275 http://eggnogapi.embl.de/nog_data/html/tree/COG0275 eggNOG ENOG4105CGJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CGJ epestfind swissprot:RSMH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RSMH_ECOLI garnier swissprot:RSMH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RSMH_ECOLI helixturnhelix swissprot:RSMH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RSMH_ECOLI hmoment swissprot:RSMH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RSMH_ECOLI iep swissprot:RSMH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RSMH_ECOLI inforesidue swissprot:RSMH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RSMH_ECOLI octanol swissprot:RSMH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RSMH_ECOLI pepcoil swissprot:RSMH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RSMH_ECOLI pepdigest swissprot:RSMH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RSMH_ECOLI pepinfo swissprot:RSMH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RSMH_ECOLI pepnet swissprot:RSMH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RSMH_ECOLI pepstats swissprot:RSMH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RSMH_ECOLI pepwheel swissprot:RSMH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RSMH_ECOLI pepwindow swissprot:RSMH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RSMH_ECOLI sigcleave swissprot:RSMH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RSMH_ECOLI ## Database ID URL or Descriptions # BioGrid 4260806 10 # CDD cd07377 WHTH_GntR # EcoGene EG11711 yidP # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:InterPro. # GO_process GO:0006351 transcription, DNA-templated; ISS:EcoCyc. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # Gene3D 3.40.1410.10 -; 1. # InterPro IPR000524 Tscrpt_reg_HTH_GntR # InterPro IPR011663 UTRA # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR028978 Chorismate_lyase_/UTRA_dom # KEGG_Brite ko03000 Transcription factors # Organism YIDP_ECOLI Escherichia coli (strain K12) # PATRIC 32122861 VBIEscCol129921_3806 # PIR E65170 E65170 # PRINTS PR00035 HTHGNTR # PROSITE PS50949 HTH_GNTR # Pfam PF00392 GntR # Pfam PF07702 UTRA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIDP_ECOLI Uncharacterized HTH-type transcriptional regulator YidP # RefSeq NP_418139 NC_000913.3 # RefSeq WP_001300779 NZ_LN832404.1 # SIMILARITY Contains 1 HTH gntR-type DNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00307}. # SMART SM00345 HTH_GNTR # SMART SM00866 UTRA # SUPFAM SSF46785 SSF46785 # SUPFAM SSF64288 SSF64288 # eggNOG COG2188 LUCA # eggNOG ENOG4105FDP Bacteria BLAST swissprot:YIDP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIDP_ECOLI BioCyc ECOL316407:JW3661-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3661-MONOMER BioCyc EcoCyc:EG11711-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11711-MONOMER COG COG2188 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2188 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1662 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1662 EcoGene EG11711 http://www.ecogene.org/geneInfo.php?eg_id=EG11711 EnsemblBacteria AAC76707 http://www.ensemblgenomes.org/id/AAC76707 EnsemblBacteria AAC76707 http://www.ensemblgenomes.org/id/AAC76707 EnsemblBacteria BAE77610 http://www.ensemblgenomes.org/id/BAE77610 EnsemblBacteria BAE77610 http://www.ensemblgenomes.org/id/BAE77610 EnsemblBacteria BAE77610 http://www.ensemblgenomes.org/id/BAE77610 EnsemblBacteria b3684 http://www.ensemblgenomes.org/id/b3684 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 3.40.1410.10 http://www.cathdb.info/version/latest/superfamily/3.40.1410.10 GeneID 948194 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948194 HOGENOM HOG000228717 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000228717&db=HOGENOM6 InParanoid P31453 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31453 IntAct P31453 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31453* InterPro IPR000524 http://www.ebi.ac.uk/interpro/entry/IPR000524 InterPro IPR011663 http://www.ebi.ac.uk/interpro/entry/IPR011663 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR028978 http://www.ebi.ac.uk/interpro/entry/IPR028978 KEGG_Brite ko03000 http://www.genome.jp/dbget-bin/www_bget?ko03000 KEGG_Gene ecj:JW3661 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3661 KEGG_Gene eco:b3684 http://www.genome.jp/dbget-bin/www_bget?eco:b3684 KEGG_Orthology KO:K03482 http://www.genome.jp/dbget-bin/www_bget?KO:K03482 OMA PMAIESS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PMAIESS PRINTS PR00035 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00035 PROSITE PS50949 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50949 PSORT swissprot:YIDP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIDP_ECOLI PSORT-B swissprot:YIDP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIDP_ECOLI PSORT2 swissprot:YIDP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIDP_ECOLI Pfam PF00392 http://pfam.xfam.org/family/PF00392 Pfam PF07702 http://pfam.xfam.org/family/PF07702 Phobius swissprot:YIDP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIDP_ECOLI PhylomeDB P31453 http://phylomedb.org/?seqid=P31453 ProteinModelPortal P31453 http://www.proteinmodelportal.org/query/uniprot/P31453 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418139 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418139 RefSeq WP_001300779 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300779 SMART SM00345 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00345 SMART SM00866 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00866 SMR P31453 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31453 STRING 511145.b3684 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3684&targetmode=cogs STRING COG2188 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2188&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SUPFAM SSF64288 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF64288 UniProtKB YIDP_ECOLI http://www.uniprot.org/uniprot/YIDP_ECOLI UniProtKB-AC P31453 http://www.uniprot.org/uniprot/P31453 charge swissprot:YIDP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIDP_ECOLI eggNOG COG2188 http://eggnogapi.embl.de/nog_data/html/tree/COG2188 eggNOG ENOG4105FDP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FDP epestfind swissprot:YIDP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIDP_ECOLI garnier swissprot:YIDP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIDP_ECOLI helixturnhelix swissprot:YIDP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIDP_ECOLI hmoment swissprot:YIDP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIDP_ECOLI iep swissprot:YIDP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIDP_ECOLI inforesidue swissprot:YIDP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIDP_ECOLI octanol swissprot:YIDP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIDP_ECOLI pepcoil swissprot:YIDP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIDP_ECOLI pepdigest swissprot:YIDP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIDP_ECOLI pepinfo swissprot:YIDP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIDP_ECOLI pepnet swissprot:YIDP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIDP_ECOLI pepstats swissprot:YIDP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIDP_ECOLI pepwheel swissprot:YIDP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIDP_ECOLI pepwindow swissprot:YIDP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIDP_ECOLI sigcleave swissprot:YIDP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIDP_ECOLI ## Database ID URL or Descriptions # AltName YNIC_ECOLI Sugar phosphatase # BIOPHYSICOCHEMICAL PROPERTIES YNIC_ECOLI Kinetic parameters KM=0.61 mM for 2dGlu6P (with manganese ions as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; KM=2.5 mM for 2dRib5P (with zinc ions as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; KM=2.6 mM for Rib5P (with zinc ions as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; KM=3.6 mM for Glu6P (with zinc ions as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; KM=4.7 mM for Man6P (with zinc ions as cofactor and at pH 9) {ECO 0000269|PubMed 16990279}; pH dependence Optimum pH is between 6 and 7.5. {ECO 0000269|PubMed 16990279}; # BioGrid 4263414 9 # CATALYTIC ACTIVITY YNIC_ECOLI 2-deoxy-D-glucose 6-phosphate + H(2)O = 2- deoxy-D-glucose + phosphate. # CATALYTIC ACTIVITY YNIC_ECOLI Sugar phosphate + H(2)O = sugar + phosphate. # COFACTOR YNIC_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000269|PubMed 16990279}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 16990279}; Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000269|PubMed 16990279}; Name=Zn(2+); Xref=ChEBI CHEBI 29105; Evidence={ECO 0000269|PubMed 16990279}; Note=Magnesium. Can also use other divalent metal cations as manganese, cobalt or zinc. {ECO 0000269|PubMed 16990279}; # DISRUPTION PHENOTYPE Cells lacking this gene are hypersensitive to 2-deoxyglucose. {ECO:0000269|PubMed 16990279}. # EcoGene EG13988 yniC # FUNCTION YNIC_ECOLI Catalyzes strongly the dephosphorylation of 2- deoxyglucose 6-phosphate (2dGlu6P) and slightly the dephosphorylation of mannose 6-phosphate (Man6P), 2-deoxyribose-5- phosphate (2dRib5P), ribose-5-phosphate (Rib5P) and glucose-6- phosphate (Glu6P). {ECO 0000269|PubMed 15808744, ECO 0000269|PubMed 16990279}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IDA:UniProtKB. # GO_function GO:0003850 2-deoxyglucose-6-phosphatase activity; IDA:EcoliWiki. # GO_function GO:0004346 glucose-6-phosphatase activity; IDA:EcoliWiki. # GO_function GO:0016791 phosphatase activity; IDA:EcoliWiki. # GO_function GO:0046872 metal ion binding; IDA:EcoliWiki. # GO_function GO:0050308 sugar-phosphatase activity; IDA:EcoliWiki. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0043167 ion binding # Gene3D 1.10.150.240 -; 1. # Gene3D 3.40.50.1000 -; 1. # IntAct P77247 8 # InterPro IPR006439 HAD-SF_hydro_IA # InterPro IPR023198 PGP_dom2 # InterPro IPR023214 HAD-like_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00051 Fructose and mannose metabolism # Organism YNIC_ECOLI Escherichia coli (strain K12) # PATRIC 32118761 VBIEscCol129921_1798 # PDB 1TE2 X-ray; 1.76 A; A/B=1-222 # PIR G64931 G64931 # PRINTS PR00413 HADHALOGNASE # Pfam PF13419 HAD_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNIC_ECOLI 2-deoxyglucose-6-phosphate phosphatase # RefSeq NP_416241 NC_000913.3 # RefSeq WP_000106833 NZ_LN832404.1 # SIMILARITY Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. {ECO 0000305}. # SUBUNIT Homodimer. {ECO 0000269|Ref.6}. # SUPFAM SSF56784 SSF56784 # TIGRFAMs TIGR01509 HAD-SF-IA-v3 # eggNOG COG0637 LUCA # eggNOG ENOG4107UW8 Bacteria BLAST swissprot:YNIC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNIC_ECOLI BioCyc ECOL316407:JW1716-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1716-MONOMER BioCyc EcoCyc:G6932-MONOMER http://biocyc.org/getid?id=EcoCyc:G6932-MONOMER BioCyc MetaCyc:G6932-MONOMER http://biocyc.org/getid?id=MetaCyc:G6932-MONOMER COG COG0637 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0637 COG COG2045 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2045 DIP DIP-12777N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12777N DOI 10.1016/j.fmrre.2004.12.006 http://dx.doi.org/10.1016/j.fmrre.2004.12.006 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M605449200 http://dx.doi.org/10.1074/jbc.M605449200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.3.23 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.23 EC_number EC:3.1.3.68 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.3.68 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.3.23 http://enzyme.expasy.org/EC/3.1.3.23 ENZYME 3.1.3.68 http://enzyme.expasy.org/EC/3.1.3.68 EchoBASE EB3744 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3744 EcoGene EG13988 http://www.ecogene.org/geneInfo.php?eg_id=EG13988 EnsemblBacteria AAC74797 http://www.ensemblgenomes.org/id/AAC74797 EnsemblBacteria AAC74797 http://www.ensemblgenomes.org/id/AAC74797 EnsemblBacteria BAA15508 http://www.ensemblgenomes.org/id/BAA15508 EnsemblBacteria BAA15508 http://www.ensemblgenomes.org/id/BAA15508 EnsemblBacteria BAA15508 http://www.ensemblgenomes.org/id/BAA15508 EnsemblBacteria b1727 http://www.ensemblgenomes.org/id/b1727 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0003850 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003850 GO_function GO:0004346 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004346 GO_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0050308 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050308 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 1.10.150.240 http://www.cathdb.info/version/latest/superfamily/1.10.150.240 Gene3D 3.40.50.1000 http://www.cathdb.info/version/latest/superfamily/3.40.50.1000 GeneID 945632 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945632 HOGENOM HOG000248341 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000248341&db=HOGENOM6 InParanoid P77247 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77247 IntAct P77247 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77247* IntEnz 3.1.3.23 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.23 IntEnz 3.1.3.68 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.3.68 InterPro IPR006439 http://www.ebi.ac.uk/interpro/entry/IPR006439 InterPro IPR023198 http://www.ebi.ac.uk/interpro/entry/IPR023198 InterPro IPR023214 http://www.ebi.ac.uk/interpro/entry/IPR023214 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1716 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1716 KEGG_Gene eco:b1727 http://www.genome.jp/dbget-bin/www_bget?eco:b1727 KEGG_Orthology KO:K01112 http://www.genome.jp/dbget-bin/www_bget?KO:K01112 KEGG_Pathway ko00051 http://www.genome.jp/kegg-bin/show_pathway?ko00051 KEGG_Reaction rn:R00118 http://www.genome.jp/dbget-bin/www_bget?rn:R00118 KEGG_Reaction rn:R00872 http://www.genome.jp/dbget-bin/www_bget?rn:R00872 KEGG_Reaction rn:R02706 http://www.genome.jp/dbget-bin/www_bget?rn:R02706 MINT MINT-1257246 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1257246 OMA WYAQQPW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WYAQQPW PDB 1TE2 http://www.ebi.ac.uk/pdbe-srv/view/entry/1TE2 PDBsum 1TE2 http://www.ebi.ac.uk/pdbsum/1TE2 PRINTS PR00413 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00413 PSORT swissprot:YNIC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNIC_ECOLI PSORT-B swissprot:YNIC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNIC_ECOLI PSORT2 swissprot:YNIC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNIC_ECOLI Pfam PF13419 http://pfam.xfam.org/family/PF13419 Phobius swissprot:YNIC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNIC_ECOLI PhylomeDB P77247 http://phylomedb.org/?seqid=P77247 ProteinModelPortal P77247 http://www.proteinmodelportal.org/query/uniprot/P77247 PubMed 15808744 http://www.ncbi.nlm.nih.gov/pubmed/15808744 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 16990279 http://www.ncbi.nlm.nih.gov/pubmed/16990279 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416241 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416241 RefSeq WP_000106833 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000106833 SMR P77247 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77247 STRING 511145.b1727 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1727&targetmode=cogs STRING COG0637 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0637&targetmode=cogs STRING COG2045 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2045&targetmode=cogs SUPFAM SSF56784 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56784 SWISS-2DPAGE P77247 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P77247 TIGRFAMs TIGR01509 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01509 UniProtKB YNIC_ECOLI http://www.uniprot.org/uniprot/YNIC_ECOLI UniProtKB-AC P77247 http://www.uniprot.org/uniprot/P77247 charge swissprot:YNIC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNIC_ECOLI eggNOG COG0637 http://eggnogapi.embl.de/nog_data/html/tree/COG0637 eggNOG ENOG4107UW8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107UW8 epestfind swissprot:YNIC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNIC_ECOLI garnier swissprot:YNIC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNIC_ECOLI helixturnhelix swissprot:YNIC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNIC_ECOLI hmoment swissprot:YNIC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNIC_ECOLI iep swissprot:YNIC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNIC_ECOLI inforesidue swissprot:YNIC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNIC_ECOLI octanol swissprot:YNIC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNIC_ECOLI pepcoil swissprot:YNIC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNIC_ECOLI pepdigest swissprot:YNIC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNIC_ECOLI pepinfo swissprot:YNIC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNIC_ECOLI pepnet swissprot:YNIC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNIC_ECOLI pepstats swissprot:YNIC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNIC_ECOLI pepwheel swissprot:YNIC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNIC_ECOLI pepwindow swissprot:YNIC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNIC_ECOLI sigcleave swissprot:YNIC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNIC_ECOLI ## Database ID URL or Descriptions # BioGrid 4259688 156 # EcoGene EG13572 wcaD # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IEA:UniProtKB-KW. # GO_process GO:0045228 slime layer polysaccharide biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # InterPro IPR024013 Colanic_acid_synth_WcaD # Organism WCAD_ECOLI Escherichia coli (strain K12) # PATHWAY WCAD_ECOLI Slime biogenesis; slime polysaccharide biosynthesis. # PATRIC 32119445 VBIEscCol129921_2133 # PIR G64971 G64971 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName WCAD_ECOLI Putative colanic acid polymerase # RefSeq NP_416560 NC_000913.3 # RefSeq WP_000107816 NZ_LN832404.1 # SUBCELLULAR LOCATION WCAD_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # TIGRFAMs TIGR04010 WcaD # eggNOG ENOG4108NYJ Bacteria # eggNOG ENOG410ZIK0 LUCA BLAST swissprot:WCAD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:WCAD_ECOLI BioCyc ECOL316407:JW2041-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2041-MONOMER BioCyc EcoCyc:G7101-MONOMER http://biocyc.org/getid?id=EcoCyc:G7101-MONOMER DIP DIP-11120N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11120N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U38473 http://www.ebi.ac.uk/ena/data/view/U38473 EchoBASE EB3342 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3342 EcoGene EG13572 http://www.ecogene.org/geneInfo.php?eg_id=EG13572 EnsemblBacteria AAC75117 http://www.ensemblgenomes.org/id/AAC75117 EnsemblBacteria AAC75117 http://www.ensemblgenomes.org/id/AAC75117 EnsemblBacteria BAE76573 http://www.ensemblgenomes.org/id/BAE76573 EnsemblBacteria BAE76573 http://www.ensemblgenomes.org/id/BAE76573 EnsemblBacteria BAE76573 http://www.ensemblgenomes.org/id/BAE76573 EnsemblBacteria b2056 http://www.ensemblgenomes.org/id/b2056 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GO_process GO:0045228 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045228 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 946550 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946550 HOGENOM HOG000267975 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267975&db=HOGENOM6 IntAct P71238 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P71238* InterPro IPR024013 http://www.ebi.ac.uk/interpro/entry/IPR024013 KEGG_Gene ecj:JW2041 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2041 KEGG_Gene eco:b2056 http://www.genome.jp/dbget-bin/www_bget?eco:b2056 KEGG_Orthology KO:K13620 http://www.genome.jp/dbget-bin/www_bget?KO:K13620 MINT MINT-1239365 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1239365 OMA WRSMSTS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WRSMSTS PSORT swissprot:WCAD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:WCAD_ECOLI PSORT-B swissprot:WCAD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:WCAD_ECOLI PSORT2 swissprot:WCAD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:WCAD_ECOLI Phobius swissprot:WCAD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:WCAD_ECOLI ProteinModelPortal P71238 http://www.proteinmodelportal.org/query/uniprot/P71238 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8759852 http://www.ncbi.nlm.nih.gov/pubmed/8759852 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416560 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416560 RefSeq WP_000107816 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000107816 STRING 511145.b2056 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2056&targetmode=cogs TIGRFAMs TIGR04010 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR04010 UniProtKB WCAD_ECOLI http://www.uniprot.org/uniprot/WCAD_ECOLI UniProtKB-AC P71238 http://www.uniprot.org/uniprot/P71238 charge swissprot:WCAD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:WCAD_ECOLI eggNOG ENOG4108NYJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108NYJ eggNOG ENOG410ZIK0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410ZIK0 epestfind swissprot:WCAD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:WCAD_ECOLI garnier swissprot:WCAD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:WCAD_ECOLI helixturnhelix swissprot:WCAD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:WCAD_ECOLI hmoment swissprot:WCAD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:WCAD_ECOLI iep swissprot:WCAD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:WCAD_ECOLI inforesidue swissprot:WCAD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:WCAD_ECOLI octanol swissprot:WCAD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:WCAD_ECOLI pepcoil swissprot:WCAD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:WCAD_ECOLI pepdigest swissprot:WCAD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:WCAD_ECOLI pepinfo swissprot:WCAD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:WCAD_ECOLI pepnet swissprot:WCAD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:WCAD_ECOLI pepstats swissprot:WCAD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:WCAD_ECOLI pepwheel swissprot:WCAD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:WCAD_ECOLI pepwindow swissprot:WCAD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:WCAD_ECOLI sigcleave swissprot:WCAD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:WCAD_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=0.05 mM for ATP {ECO 0000269|PubMed:8419285}; # BRENDA 3.6.4.12 2026 # BioGrid 4263340 239 # CATALYTIC ACTIVITY UVRD_ECOLI ATP + H(2)O = ADP + phosphate. # DISRUPTION PHENOTYPE Strongly sensitive to UV, ciprofloxacin (CFX), and azidothymidine (AZT) in single deletion mutants, radA- uvrD double deletions are more sensitive yet. Adding recF mutations almost completely suppresses AZT and partially suppresses UV and CFX sensitivity, suggesting RadA processes a class of intermediates that accumulate in uvrD mutants (PubMed:25484163). {ECO 0000269|PubMed:25484163}. # EcoGene EG11064 uvrD # FUNCTION UVRD_ECOLI A helicase with DNA-dependent ATPase activity (PubMed 8419285). Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand. Initiates unwinding more efficiently from a nicked substrate than ds duplex DNA (PubMed 8419285). Involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair, and probably also in repair of alkylated DNA (Probable). {ECO 0000269|PubMed 8419285, ECO 0000305|PubMed 25484163}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_function GO:0003678 DNA helicase activity; IDA:CACAO. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0015616 DNA translocase activity; IDA:EcoCyc. # GO_function GO:0017116 single-stranded DNA-dependent ATP-dependent DNA helicase activity; IDA:EcoCyc. # GO_process GO:0006268 DNA unwinding involved in DNA replication; IEA:InterPro. # GO_process GO:0006289 nucleotide-excision repair; IDA:EcoCyc. # GO_process GO:0006298 mismatch repair; IMP:EcoCyc. # GO_process GO:0009432 SOS response; IEA:UniProtKB-KW. # GO_process GO:0031297 replication fork processing; IMP:EcoCyc. # GO_process GO:0032508 DNA duplex unwinding; IDA:EcoCyc. # GO_process GO:0051260 protein homooligomerization; IDA:EcoCyc. # GO_process GO:0070581 rolling circle DNA replication; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004386 helicase activity # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006461 protein complex assembly # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0051276 chromosome organization # Gene3D 1.10.10.160 -; 1. # Gene3D 3.40.50.300 -; 4. # INTERACTION UVRD_ECOLI P0A9P0 lpdA; NbExp=2; IntAct=EBI-559573, EBI-542856; P25665 metE; NbExp=2; IntAct=EBI-559573, EBI-551247; P23367 mutL; NbExp=7; IntAct=EBI-559573, EBI-554913; # IntAct P03018 37 # InterPro IPR000212 DNA_helicase_UvrD/REP # InterPro IPR005753 DNA_helicase_ATP-dep_UvrD # InterPro IPR013986 DExx_box_DNA_helicase_dom # InterPro IPR014016 UvrD-like_ATP-bd # InterPro IPR014017 DNA_helicase_UvrD-like_C # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Pathway ko03420 Nucleotide excision repair # KEGG_Pathway ko03430 Mismatch repair # Organism UVRD_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11070 PTHR11070 # PATRIC 32123127 VBIEscCol129921_3929 # PDB 2IS1 X-ray; 2.90 A; A/B=1-680 # PDB 2IS2 X-ray; 3.00 A; A/B=1-680 # PDB 2IS4 X-ray; 2.60 A; A/B=1-680 # PDB 2IS6 X-ray; 2.20 A; A/B=1-680 # PDB 3LFU X-ray; 1.80 A; A=1-647 # PIR F65185 HJECD2 # PROSITE PS51198 UVRD_HELICASE_ATP_BIND # PROSITE PS51217 UVRD_HELICASE_CTER # Pfam PF00580 UvrD-helicase # Pfam PF13361 UvrD_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UVRD_ECOLI DNA helicase II # RefSeq NP_418258 NC_000913.3 # RefSeq WP_000383406 NZ_LN832404.1 # SIMILARITY Belongs to the helicase family. UvrD subfamily. {ECO 0000305}. # SIMILARITY Contains 1 uvrD-like helicase ATP-binding domain. {ECO:0000255|PROSITE-ProRule PRU00560}. # SIMILARITY Contains 1 uvrD-like helicase C-terminal domain. {ECO:0000255|PROSITE-ProRule PRU00617}. # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR01075 uvrD # eggNOG COG0210 LUCA # eggNOG ENOG4105C4R Bacteria BLAST swissprot:UVRD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UVRD_ECOLI BioCyc ECOL316407:JW3786-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3786-MONOMER BioCyc EcoCyc:EG11064-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11064-MONOMER COG COG0210 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0210 DIP DIP-11103N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11103N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/11.24.8625 http://dx.doi.org/10.1093/nar/11.24.8625 DOI 10.1093/nar/12.14.5789 http://dx.doi.org/10.1093/nar/12.14.5789 DOI 10.1111/mmi.12899 http://dx.doi.org/10.1111/mmi.12899 DOI 10.1126/science.1379743 http://dx.doi.org/10.1126/science.1379743 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DisProt DP00684 http://www.disprot.org/protein.php?id=DP00684 EC_number EC:3.6.4.12 http://www.genome.jp/dbget-bin/www_bget?EC:3.6.4.12 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D00069 http://www.ebi.ac.uk/ena/data/view/D00069 EMBL M38257 http://www.ebi.ac.uk/ena/data/view/M38257 EMBL M87049 http://www.ebi.ac.uk/ena/data/view/M87049 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X00225 http://www.ebi.ac.uk/ena/data/view/X00225 EMBL X00738 http://www.ebi.ac.uk/ena/data/view/X00738 EMBL X04037 http://www.ebi.ac.uk/ena/data/view/X04037 ENZYME 3.6.4.12 http://enzyme.expasy.org/EC/3.6.4.12 EchoBASE EB1057 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1057 EcoGene EG11064 http://www.ecogene.org/geneInfo.php?eg_id=EG11064 EnsemblBacteria AAC76816 http://www.ensemblgenomes.org/id/AAC76816 EnsemblBacteria AAC76816 http://www.ensemblgenomes.org/id/AAC76816 EnsemblBacteria BAE77487 http://www.ensemblgenomes.org/id/BAE77487 EnsemblBacteria BAE77487 http://www.ensemblgenomes.org/id/BAE77487 EnsemblBacteria BAE77487 http://www.ensemblgenomes.org/id/BAE77487 EnsemblBacteria b3813 http://www.ensemblgenomes.org/id/b3813 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003678 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003678 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0015616 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015616 GO_function GO:0017116 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017116 GO_process GO:0006268 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006268 GO_process GO:0006289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006289 GO_process GO:0006298 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006298 GO_process GO:0009432 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009432 GO_process GO:0031297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031297 GO_process GO:0032508 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032508 GO_process GO:0051260 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051260 GO_process GO:0070581 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070581 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004386 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004386 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006461 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006461 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0051276 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051276 Gene3D 1.10.10.160 http://www.cathdb.info/version/latest/superfamily/1.10.10.160 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 948347 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948347 HOGENOM HOG000033016 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000033016&db=HOGENOM6 InParanoid P03018 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P03018 IntAct P03018 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P03018* IntEnz 3.6.4.12 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.4.12 InterPro IPR000212 http://www.ebi.ac.uk/interpro/entry/IPR000212 InterPro IPR005753 http://www.ebi.ac.uk/interpro/entry/IPR005753 InterPro IPR013986 http://www.ebi.ac.uk/interpro/entry/IPR013986 InterPro IPR014016 http://www.ebi.ac.uk/interpro/entry/IPR014016 InterPro IPR014017 http://www.ebi.ac.uk/interpro/entry/IPR014017 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW3786 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3786 KEGG_Gene eco:b3813 http://www.genome.jp/dbget-bin/www_bget?eco:b3813 KEGG_Orthology KO:K03657 http://www.genome.jp/dbget-bin/www_bget?KO:K03657 KEGG_Pathway ko03420 http://www.genome.jp/kegg-bin/show_pathway?ko03420 KEGG_Pathway ko03430 http://www.genome.jp/kegg-bin/show_pathway?ko03430 MINT MINT-1223204 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1223204 OMA RLQIAFQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RLQIAFQ PANTHER PTHR11070 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11070 PDB 2IS1 http://www.ebi.ac.uk/pdbe-srv/view/entry/2IS1 PDB 2IS2 http://www.ebi.ac.uk/pdbe-srv/view/entry/2IS2 PDB 2IS4 http://www.ebi.ac.uk/pdbe-srv/view/entry/2IS4 PDB 2IS6 http://www.ebi.ac.uk/pdbe-srv/view/entry/2IS6 PDB 3LFU http://www.ebi.ac.uk/pdbe-srv/view/entry/3LFU PDBsum 2IS1 http://www.ebi.ac.uk/pdbsum/2IS1 PDBsum 2IS2 http://www.ebi.ac.uk/pdbsum/2IS2 PDBsum 2IS4 http://www.ebi.ac.uk/pdbsum/2IS4 PDBsum 2IS6 http://www.ebi.ac.uk/pdbsum/2IS6 PDBsum 3LFU http://www.ebi.ac.uk/pdbsum/3LFU PROSITE PS51198 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51198 PROSITE PS51217 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51217 PSORT swissprot:UVRD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UVRD_ECOLI PSORT-B swissprot:UVRD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UVRD_ECOLI PSORT2 swissprot:UVRD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UVRD_ECOLI Pfam PF00580 http://pfam.xfam.org/family/PF00580 Pfam PF13361 http://pfam.xfam.org/family/PF13361 Phobius swissprot:UVRD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UVRD_ECOLI PhylomeDB P03018 http://phylomedb.org/?seqid=P03018 ProteinModelPortal P03018 http://www.proteinmodelportal.org/query/uniprot/P03018 PubMed 1379743 http://www.ncbi.nlm.nih.gov/pubmed/1379743 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2254268 http://www.ncbi.nlm.nih.gov/pubmed/2254268 PubMed 25484163 http://www.ncbi.nlm.nih.gov/pubmed/25484163 PubMed 2943729 http://www.ncbi.nlm.nih.gov/pubmed/2943729 PubMed 6324092 http://www.ncbi.nlm.nih.gov/pubmed/6324092 PubMed 6379604 http://www.ncbi.nlm.nih.gov/pubmed/6379604 PubMed 8419285 http://www.ncbi.nlm.nih.gov/pubmed/8419285 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418258 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418258 RefSeq WP_000383406 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000383406 SMR P03018 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P03018 STRING 511145.b3813 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3813&targetmode=cogs STRING COG0210 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0210&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR01075 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01075 UniProtKB UVRD_ECOLI http://www.uniprot.org/uniprot/UVRD_ECOLI UniProtKB-AC P03018 http://www.uniprot.org/uniprot/P03018 charge swissprot:UVRD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UVRD_ECOLI eggNOG COG0210 http://eggnogapi.embl.de/nog_data/html/tree/COG0210 eggNOG ENOG4105C4R http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C4R epestfind swissprot:UVRD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UVRD_ECOLI garnier swissprot:UVRD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UVRD_ECOLI helixturnhelix swissprot:UVRD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UVRD_ECOLI hmoment swissprot:UVRD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UVRD_ECOLI iep swissprot:UVRD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UVRD_ECOLI inforesidue swissprot:UVRD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UVRD_ECOLI octanol swissprot:UVRD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UVRD_ECOLI pepcoil swissprot:UVRD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UVRD_ECOLI pepdigest swissprot:UVRD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UVRD_ECOLI pepinfo swissprot:UVRD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UVRD_ECOLI pepnet swissprot:UVRD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UVRD_ECOLI pepstats swissprot:UVRD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UVRD_ECOLI pepwheel swissprot:UVRD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UVRD_ECOLI pepwindow swissprot:UVRD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UVRD_ECOLI sigcleave swissprot:UVRD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UVRD_ECOLI ## Database ID URL or Descriptions # EcoGene EG13971 ydiL # GO_function GO:0003677 DNA binding; IEA:InterPro. # GOslim_function GO:0003677 DNA binding # Gene3D 1.10.3100.10 -; 1. # InterPro IPR010982 Lambda_DNA-bd_dom # InterPro IPR015060 DUF1870 # InterPro IPR027910 YdiL-like # Organism YDIL_ECOLI Escherichia coli (strain K12) # PATRIC 32118684 VBIEscCol129921_1760 # PIR A64927 A64927 # Pfam PF08965 DUF1870 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDIL_ECOLI Uncharacterized protein YdiL # RefSeq NP_416204 NC_000913.3 # RefSeq WP_001310864 NZ_LN832404.1 # SUPFAM SSF47413 SSF47413 # eggNOG ENOG4105SUA Bacteria # eggNOG ENOG41120Y0 LUCA BLAST swissprot:YDIL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDIL_ECOLI BioCyc ECOL316407:JW1679-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1679-MONOMER BioCyc EcoCyc:G6915-MONOMER http://biocyc.org/getid?id=EcoCyc:G6915-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3728 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3728 EcoGene EG13971 http://www.ecogene.org/geneInfo.php?eg_id=EG13971 EnsemblBacteria AAC74759 http://www.ensemblgenomes.org/id/AAC74759 EnsemblBacteria AAC74759 http://www.ensemblgenomes.org/id/AAC74759 EnsemblBacteria BAE76502 http://www.ensemblgenomes.org/id/BAE76502 EnsemblBacteria BAE76502 http://www.ensemblgenomes.org/id/BAE76502 EnsemblBacteria BAE76502 http://www.ensemblgenomes.org/id/BAE76502 EnsemblBacteria b1689 http://www.ensemblgenomes.org/id/b1689 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 Gene3D 1.10.3100.10 http://www.cathdb.info/version/latest/superfamily/1.10.3100.10 GeneID 946181 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946181 HOGENOM HOG000009474 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009474&db=HOGENOM6 IntAct P76196 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76196* InterPro IPR010982 http://www.ebi.ac.uk/interpro/entry/IPR010982 InterPro IPR015060 http://www.ebi.ac.uk/interpro/entry/IPR015060 InterPro IPR027910 http://www.ebi.ac.uk/interpro/entry/IPR027910 KEGG_Gene ecj:JW1679 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1679 KEGG_Gene eco:b1689 http://www.genome.jp/dbget-bin/www_bget?eco:b1689 OMA VANELYS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VANELYS PSORT swissprot:YDIL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDIL_ECOLI PSORT-B swissprot:YDIL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDIL_ECOLI PSORT2 swissprot:YDIL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDIL_ECOLI Pfam PF08965 http://pfam.xfam.org/family/PF08965 Phobius swissprot:YDIL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDIL_ECOLI ProteinModelPortal P76196 http://www.proteinmodelportal.org/query/uniprot/P76196 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416204 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416204 RefSeq WP_001310864 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001310864 SMR P76196 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76196 STRING 511145.b1689 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1689&targetmode=cogs SUPFAM SSF47413 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF47413 UniProtKB YDIL_ECOLI http://www.uniprot.org/uniprot/YDIL_ECOLI UniProtKB-AC P76196 http://www.uniprot.org/uniprot/P76196 charge swissprot:YDIL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDIL_ECOLI eggNOG ENOG4105SUA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105SUA eggNOG ENOG41120Y0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG41120Y0 epestfind swissprot:YDIL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDIL_ECOLI garnier swissprot:YDIL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDIL_ECOLI helixturnhelix swissprot:YDIL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDIL_ECOLI hmoment swissprot:YDIL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDIL_ECOLI iep swissprot:YDIL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDIL_ECOLI inforesidue swissprot:YDIL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDIL_ECOLI octanol swissprot:YDIL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDIL_ECOLI pepcoil swissprot:YDIL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDIL_ECOLI pepdigest swissprot:YDIL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDIL_ECOLI pepinfo swissprot:YDIL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDIL_ECOLI pepnet swissprot:YDIL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDIL_ECOLI pepstats swissprot:YDIL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDIL_ECOLI pepwheel swissprot:YDIL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDIL_ECOLI pepwindow swissprot:YDIL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDIL_ECOLI sigcleave swissprot:YDIL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDIL_ECOLI ## Database ID URL or Descriptions # BioGrid 4262076 15 # EcoGene EG12949 yfdN # InterPro IPR020344 Phage_SfV_Orf40 # InterPro IPR024684 Tscrpt_act_PerC/SfV_Orf40 # Organism YFDN_ECOLI Escherichia coli (strain K12) # PATRIC 32120089 VBIEscCol129921_2453 # PIR B65009 B65009 # Pfam PF06069 PerC # ProDom PD096295 Uncharacterised_YfdN # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFDN_ECOLI Uncharacterized protein YfdN # RefSeq NP_416858 NC_000913.3 BLAST swissprot:YFDN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFDN_ECOLI BioCyc ECOL316407:JW5385-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5385-MONOMER BioCyc EcoCyc:G7226-MONOMER http://biocyc.org/getid?id=EcoCyc:G7226-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/14.17.7115 http://dx.doi.org/10.1093/nar/14.17.7115 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X04387 http://www.ebi.ac.uk/ena/data/view/X04387 EchoBASE EB2783 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2783 EcoGene EG12949 http://www.ecogene.org/geneInfo.php?eg_id=EG12949 EnsemblBacteria AAC75416 http://www.ensemblgenomes.org/id/AAC75416 EnsemblBacteria AAC75416 http://www.ensemblgenomes.org/id/AAC75416 EnsemblBacteria BAE76697 http://www.ensemblgenomes.org/id/BAE76697 EnsemblBacteria BAE76697 http://www.ensemblgenomes.org/id/BAE76697 EnsemblBacteria BAE76697 http://www.ensemblgenomes.org/id/BAE76697 EnsemblBacteria b2357 http://www.ensemblgenomes.org/id/b2357 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946419 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946419 HOGENOM HOG000123848 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000123848&db=HOGENOM6 InterPro IPR020344 http://www.ebi.ac.uk/interpro/entry/IPR020344 InterPro IPR024684 http://www.ebi.ac.uk/interpro/entry/IPR024684 KEGG_Gene ecj:JW5385 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5385 KEGG_Gene eco:b2357 http://www.genome.jp/dbget-bin/www_bget?eco:b2357 OMA CLRKSRK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CLRKSRK PSORT swissprot:YFDN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFDN_ECOLI PSORT-B swissprot:YFDN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFDN_ECOLI PSORT2 swissprot:YFDN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFDN_ECOLI Pfam PF06069 http://pfam.xfam.org/family/PF06069 Phobius swissprot:YFDN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFDN_ECOLI ProteinModelPortal P76510 http://www.proteinmodelportal.org/query/uniprot/P76510 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3532033 http://www.ncbi.nlm.nih.gov/pubmed/3532033 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416858 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416858 SMR P76510 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76510 STRING 511145.b2357 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2357&targetmode=cogs UniProtKB YFDN_ECOLI http://www.uniprot.org/uniprot/YFDN_ECOLI UniProtKB-AC P76510 http://www.uniprot.org/uniprot/P76510 charge swissprot:YFDN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFDN_ECOLI epestfind swissprot:YFDN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFDN_ECOLI garnier swissprot:YFDN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFDN_ECOLI helixturnhelix swissprot:YFDN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFDN_ECOLI hmoment swissprot:YFDN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFDN_ECOLI iep swissprot:YFDN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFDN_ECOLI inforesidue swissprot:YFDN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFDN_ECOLI octanol swissprot:YFDN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFDN_ECOLI pepcoil swissprot:YFDN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFDN_ECOLI pepdigest swissprot:YFDN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFDN_ECOLI pepinfo swissprot:YFDN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFDN_ECOLI pepnet swissprot:YFDN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFDN_ECOLI pepstats swissprot:YFDN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFDN_ECOLI pepwheel swissprot:YFDN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFDN_ECOLI pepwindow swissprot:YFDN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFDN_ECOLI sigcleave swissprot:YFDN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFDN_ECOLI ## Database ID URL or Descriptions # EcoGene EG13873 ymdA # INDUCTION Under control of the CsgD transcription factor, part of the csgBAC/ymdA operon. {ECO:0000269|PubMed 17010156}. # Organism YMDA_ECOLI Escherichia coli (strain K12) # PATRIC 32117325 VBIEscCol129921_1085 # PIR A64847 A64847 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YMDA_ECOLI Uncharacterized protein YmdA # RefSeq NP_415562 NC_000913.3 # RefSeq WP_000489587 NZ_LN832404.1 # SIMILARITY To the N-terminal of the FimA/PapA family of fimbria proteins. {ECO 0000305}. BLAST swissprot:YMDA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YMDA_ECOLI BioCyc ECOL316407:JW1031-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1031-MONOMER BioCyc EcoCyc:G6549-MONOMER http://biocyc.org/getid?id=EcoCyc:G6549-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1365-2958.2006.05440.x http://dx.doi.org/10.1111/j.1365-2958.2006.05440.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3632 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3632 EcoGene EG13873 http://www.ecogene.org/geneInfo.php?eg_id=EG13873 EnsemblBacteria AAC74128 http://www.ensemblgenomes.org/id/AAC74128 EnsemblBacteria AAC74128 http://www.ensemblgenomes.org/id/AAC74128 EnsemblBacteria BAA35834 http://www.ensemblgenomes.org/id/BAA35834 EnsemblBacteria BAA35834 http://www.ensemblgenomes.org/id/BAA35834 EnsemblBacteria BAA35834 http://www.ensemblgenomes.org/id/BAA35834 EnsemblBacteria b1044 http://www.ensemblgenomes.org/id/b1044 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 949012 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949012 HOGENOM HOG000118973 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118973&db=HOGENOM6 KEGG_Gene ecj:JW1031 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1031 KEGG_Gene eco:b1044 http://www.genome.jp/dbget-bin/www_bget?eco:b1044 OMA SMKYLNP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SMKYLNP PSORT swissprot:YMDA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YMDA_ECOLI PSORT-B swissprot:YMDA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YMDA_ECOLI PSORT2 swissprot:YMDA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YMDA_ECOLI Phobius swissprot:YMDA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YMDA_ECOLI ProteinModelPortal P75917 http://www.proteinmodelportal.org/query/uniprot/P75917 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17010156 http://www.ncbi.nlm.nih.gov/pubmed/17010156 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415562 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415562 RefSeq WP_000489587 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000489587 SMR P75917 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75917 STRING 511145.b1044 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1044&targetmode=cogs UniProtKB YMDA_ECOLI http://www.uniprot.org/uniprot/YMDA_ECOLI UniProtKB-AC P75917 http://www.uniprot.org/uniprot/P75917 charge swissprot:YMDA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YMDA_ECOLI epestfind swissprot:YMDA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YMDA_ECOLI garnier swissprot:YMDA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YMDA_ECOLI helixturnhelix swissprot:YMDA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YMDA_ECOLI hmoment swissprot:YMDA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YMDA_ECOLI iep swissprot:YMDA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YMDA_ECOLI inforesidue swissprot:YMDA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YMDA_ECOLI octanol swissprot:YMDA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YMDA_ECOLI pepcoil swissprot:YMDA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YMDA_ECOLI pepdigest swissprot:YMDA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YMDA_ECOLI pepinfo swissprot:YMDA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YMDA_ECOLI pepnet swissprot:YMDA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YMDA_ECOLI pepstats swissprot:YMDA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YMDA_ECOLI pepwheel swissprot:YMDA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YMDA_ECOLI pepwindow swissprot:YMDA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YMDA_ECOLI sigcleave swissprot:YMDA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YMDA_ECOLI ## Database ID URL or Descriptions # AltName GBBP {ECO:0000303|PubMed 3305496} # BioGrid 4262270 7 # EcoGene EG10773 proX # FUNCTION PROX_ECOLI Part of the ProU ABC transporter complex involved in glycine betaine and proline betaine uptake. Binds glycine betaine and proline betaine with high affinity. {ECO 0000269|PubMed 14612446, ECO 0000269|PubMed 23249124, ECO 0000269|PubMed 3305496, ECO 0000269|PubMed 7898450}. # GO_component GO:0042597 periplasmic space; IEA:UniProtKB-SubCell. # GO_function GO:0005215 transporter activity; IEA:InterPro. # GO_process GO:0006865 amino acid transport; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006810 transport # INDUCTION By cold shock in a PNPase-dependent fashion. {ECO:0000269|PubMed 14527658}. # INTERACTION PROX_ECOLI P77165 yagT; NbExp=2; IntAct=EBI-1129961, EBI-1115563; # IntAct P0AFM2 2 # InterPro IPR007210 ABC_Gly_betaine_transp_sub-bd # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00208 Glycine betaine/proline transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism PROX_ECOLI Escherichia coli (strain K12) # PATRIC 32120748 VBIEscCol129921_2771 # PDB 1R9L X-ray; 1.59 A; A=22-330 # PDB 1R9Q X-ray; 2.05 A; A=22-330 # PIR JS0130 BLECGP # Pfam PF04069 OpuAC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Glycine betaine/proline betaine-binding periplasmic protein {ECO 0000305} # RefSeq NP_417165 NC_000913.3 # RefSeq WP_001216525 NZ_LN832404.1 # SUBCELLULAR LOCATION PROX_ECOLI Periplasm {ECO 0000269|PubMed 3305496, ECO 0000269|PubMed 7898450}. # SUBUNIT The complex is composed of two ATP-binding proteins (ProV), two transmembrane proteins (ProW) and a solute-binding protein (ProX). {ECO:0000269|PubMed 23249124}. # TCDB 3.A.1.12 the atp-binding cassette (abc) superfamily # eggNOG COG2113 LUCA # eggNOG ENOG4105GIJ Bacteria BLAST swissprot:PROX_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PROX_ECOLI BioCyc ECOL316407:JW2654-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2654-MONOMER BioCyc EcoCyc:PROX-MONOMER http://biocyc.org/getid?id=EcoCyc:PROX-MONOMER BioCyc MetaCyc:PROX-MONOMER http://biocyc.org/getid?id=MetaCyc:PROX-MONOMER COG COG2113 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2113 DOI 10.1007/BF00290728 http://dx.doi.org/10.1007/BF00290728 DOI 10.1016/S0923-2508(03)00167-0 http://dx.doi.org/10.1016/S0923-2508(03)00167-0 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M309771200 http://dx.doi.org/10.1074/jbc.M309771200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.3109/09687688.2012.754060 http://dx.doi.org/10.3109/09687688.2012.754060 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M24856 http://www.ebi.ac.uk/ena/data/view/M24856 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0766 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0766 EcoGene EG10773 http://www.ecogene.org/geneInfo.php?eg_id=EG10773 EnsemblBacteria AAC75726 http://www.ensemblgenomes.org/id/AAC75726 EnsemblBacteria AAC75726 http://www.ensemblgenomes.org/id/AAC75726 EnsemblBacteria BAA16544 http://www.ensemblgenomes.org/id/BAA16544 EnsemblBacteria BAA16544 http://www.ensemblgenomes.org/id/BAA16544 EnsemblBacteria BAA16544 http://www.ensemblgenomes.org/id/BAA16544 EnsemblBacteria b2679 http://www.ensemblgenomes.org/id/b2679 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0042597 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042597 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_process GO:0006865 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006865 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 947165 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947165 HOGENOM HOG000282038 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000282038&db=HOGENOM6 InParanoid P0AFM2 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFM2 IntAct P0AFM2 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFM2* InterPro IPR007210 http://www.ebi.ac.uk/interpro/entry/IPR007210 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2654 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2654 KEGG_Gene eco:b2679 http://www.genome.jp/dbget-bin/www_bget?eco:b2679 KEGG_Orthology KO:K02002 http://www.genome.jp/dbget-bin/www_bget?KO:K02002 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA TAEKYHI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TAEKYHI PDB 1R9L http://www.ebi.ac.uk/pdbe-srv/view/entry/1R9L PDB 1R9Q http://www.ebi.ac.uk/pdbe-srv/view/entry/1R9Q PDBsum 1R9L http://www.ebi.ac.uk/pdbsum/1R9L PDBsum 1R9Q http://www.ebi.ac.uk/pdbsum/1R9Q PSORT swissprot:PROX_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PROX_ECOLI PSORT-B swissprot:PROX_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PROX_ECOLI PSORT2 swissprot:PROX_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PROX_ECOLI Pfam PF04069 http://pfam.xfam.org/family/PF04069 Phobius swissprot:PROX_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PROX_ECOLI PhylomeDB P0AFM2 http://phylomedb.org/?seqid=P0AFM2 ProteinModelPortal P0AFM2 http://www.proteinmodelportal.org/query/uniprot/P0AFM2 PubMed 14527658 http://www.ncbi.nlm.nih.gov/pubmed/14527658 PubMed 14612446 http://www.ncbi.nlm.nih.gov/pubmed/14612446 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 23249124 http://www.ncbi.nlm.nih.gov/pubmed/23249124 PubMed 2649479 http://www.ncbi.nlm.nih.gov/pubmed/2649479 PubMed 3305496 http://www.ncbi.nlm.nih.gov/pubmed/3305496 PubMed 7898450 http://www.ncbi.nlm.nih.gov/pubmed/7898450 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417165 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417165 RefSeq WP_001216525 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001216525 SMR P0AFM2 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFM2 STRING 511145.b2679 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2679&targetmode=cogs STRING COG2113 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2113&targetmode=cogs SWISS-2DPAGE P0AFM2 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AFM2 TCDB 3.A.1.12 http://www.tcdb.org/search/result.php?tc=3.A.1.12 UniProtKB PROX_ECOLI http://www.uniprot.org/uniprot/PROX_ECOLI UniProtKB-AC P0AFM2 http://www.uniprot.org/uniprot/P0AFM2 charge swissprot:PROX_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PROX_ECOLI eggNOG COG2113 http://eggnogapi.embl.de/nog_data/html/tree/COG2113 eggNOG ENOG4105GIJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105GIJ epestfind swissprot:PROX_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PROX_ECOLI garnier swissprot:PROX_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PROX_ECOLI helixturnhelix swissprot:PROX_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PROX_ECOLI hmoment swissprot:PROX_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PROX_ECOLI iep swissprot:PROX_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PROX_ECOLI inforesidue swissprot:PROX_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PROX_ECOLI octanol swissprot:PROX_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PROX_ECOLI pepcoil swissprot:PROX_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PROX_ECOLI pepdigest swissprot:PROX_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PROX_ECOLI pepinfo swissprot:PROX_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PROX_ECOLI pepnet swissprot:PROX_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PROX_ECOLI pepstats swissprot:PROX_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PROX_ECOLI pepwheel swissprot:PROX_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PROX_ECOLI pepwindow swissprot:PROX_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PROX_ECOLI sigcleave swissprot:PROX_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PROX_ECOLI ## Database ID URL or Descriptions # AltName BIOD1_ECOLI DTB synthetase 1 # AltName BIOD1_ECOLI Dethiobiotin synthase # BioGrid 4259956 11 # CATALYTIC ACTIVITY ATP + 7,8-diaminononanoate + CO(2) = ADP + phosphate + dethiobiotin. {ECO:0000269|PubMed 4921568}. # COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI 18420; # EcoGene EG10120 bioD1 # FUNCTION BIOD1_ECOLI Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring. Only CTP can partially replace ATP while diaminobiotin is only 37% as effective as 7,8-diaminopelargonic acid. {ECO 0000269|PubMed 4892372, ECO 0000269|PubMed 4921568}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IDA:UniProtKB. # GO_function GO:0004141 dethiobiotin synthase activity; IDA:UniProtKB. # GO_function GO:0005524 ATP binding; IDA:UniProtKB. # GO_process GO:0009102 biotin biosynthetic process; IDA:UniProtKB. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.300 -; 1. # HAMAP MF_00336 BioD # IntAct P13000 3 # InterPro IPR004472 DTB_synth_BioD # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00780 Biotin metabolism # Organism BIOD1_ECOLI Escherichia coli (strain K12) # PATHWAY Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate step 1/2. # PATRIC 32116757 VBIEscCol129921_0804 # PDB 1A82 X-ray; 1.80 A; A=2-225 # PDB 1BS1 X-ray; 1.80 A; A=2-225 # PDB 1BYI X-ray; 0.97 A; A=2-225 # PDB 1DAD X-ray; 1.60 A; A=2-225 # PDB 1DAE X-ray; 1.70 A; A=2-225 # PDB 1DAF X-ray; 1.70 A; A=2-225 # PDB 1DAG X-ray; 1.64 A; A=2-225 # PDB 1DAH X-ray; 1.64 A; A=2-225 # PDB 1DAI X-ray; 1.64 A; A=2-225 # PDB 1DAK X-ray; 1.60 A; A=2-225 # PDB 1DAM X-ray; 1.80 A; A=2-225 # PDB 1DBS X-ray; 1.80 A; A=2-225 # PDB 1DTS X-ray; 1.65 A; A=1-224 # PIR B64814 SYECDB # PIRSF PIRSF006755 DTB_synth # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BIOD1_ECOLI ATP-dependent dethiobiotin synthetase BioD 1 # RefSeq NP_415299 NC_000913.3 # RefSeq WP_000044843 NZ_LN832404.1 # SIMILARITY Belongs to the dethiobiotin synthetase family. {ECO 0000305}. # SUBCELLULAR LOCATION BIOD1_ECOLI Cytoplasm. # SUBUNIT BIOD1_ECOLI Homodimer. {ECO 0000269|PubMed 4921568, ECO 0000269|PubMed 7669756, ECO 0000269|PubMed 7881906, ECO 0000269|PubMed 8081756, ECO 0000269|PubMed 9576910, ECO 0000269|PubMed 9865950}. # SUPFAM SSF52540 SSF52540 # TIGRFAMs TIGR00347 bioD # UniPathway UPA00078 UER00161 # eggNOG COG0132 LUCA # eggNOG ENOG4105E78 Bacteria BLAST swissprot:BIOD1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BIOD1_ECOLI BioCyc ECOL316407:JW0761-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0761-MONOMER BioCyc EcoCyc:DETHIOBIOTIN-SYN-MONOMER http://biocyc.org/getid?id=EcoCyc:DETHIOBIOTIN-SYN-MONOMER BioCyc MetaCyc:DETHIOBIOTIN-SYN-MONOMER http://biocyc.org/getid?id=MetaCyc:DETHIOBIOTIN-SYN-MONOMER COG COG0132 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0132 DOI 10.1002/pro.5560071209 http://dx.doi.org/10.1002/pro.5560071209 DOI 10.1006/jmbi.1994.1030 http://dx.doi.org/10.1006/jmbi.1994.1030 DOI 10.1016/S0969-2126(00)00042-3 http://dx.doi.org/10.1016/S0969-2126(00)00042-3 DOI 10.1016/S0969-2126(94)00109-X http://dx.doi.org/10.1016/S0969-2126(94)00109-X DOI 10.1021/bi00035a004 http://dx.doi.org/10.1021/bi00035a004 DOI 10.1021/bi9631677 http://dx.doi.org/10.1021/bi9631677 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.95.10.5495 http://dx.doi.org/10.1073/pnas.95.10.5495 DOI 10.1107/S090744499801381X http://dx.doi.org/10.1107/S090744499801381X DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.3.3.3 http://www.genome.jp/dbget-bin/www_bget?EC:6.3.3.3 EMBL A11538 http://www.ebi.ac.uk/ena/data/view/A11538 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J04423 http://www.ebi.ac.uk/ena/data/view/J04423 EMBL S68059 http://www.ebi.ac.uk/ena/data/view/S68059 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 6.3.3.3 http://enzyme.expasy.org/EC/6.3.3.3 EchoBASE EB0118 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0118 EcoGene EG10120 http://www.ecogene.org/geneInfo.php?eg_id=EG10120 EnsemblBacteria AAC73865 http://www.ensemblgenomes.org/id/AAC73865 EnsemblBacteria AAC73865 http://www.ensemblgenomes.org/id/AAC73865 EnsemblBacteria BAE76365 http://www.ensemblgenomes.org/id/BAE76365 EnsemblBacteria BAE76365 http://www.ensemblgenomes.org/id/BAE76365 EnsemblBacteria BAE76365 http://www.ensemblgenomes.org/id/BAE76365 EnsemblBacteria b0778 http://www.ensemblgenomes.org/id/b0778 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0004141 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004141 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0009102 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009102 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945387 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945387 HAMAP MF_00336 http://hamap.expasy.org/unirule/MF_00336 HOGENOM HOG000275032 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275032&db=HOGENOM6 InParanoid P13000 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P13000 IntAct P13000 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P13000* IntEnz 6.3.3.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.3.3 InterPro IPR004472 http://www.ebi.ac.uk/interpro/entry/IPR004472 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0761 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0761 KEGG_Gene eco:b0778 http://www.genome.jp/dbget-bin/www_bget?eco:b0778 KEGG_Orthology KO:K01935 http://www.genome.jp/dbget-bin/www_bget?KO:K01935 KEGG_Pathway ko00780 http://www.genome.jp/kegg-bin/show_pathway?ko00780 KEGG_Reaction rn:R03182 http://www.genome.jp/dbget-bin/www_bget?rn:R03182 OMA CINHAVL http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CINHAVL PDB 1A82 http://www.ebi.ac.uk/pdbe-srv/view/entry/1A82 PDB 1BS1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1BS1 PDB 1BYI http://www.ebi.ac.uk/pdbe-srv/view/entry/1BYI PDB 1DAD http://www.ebi.ac.uk/pdbe-srv/view/entry/1DAD PDB 1DAE http://www.ebi.ac.uk/pdbe-srv/view/entry/1DAE PDB 1DAF http://www.ebi.ac.uk/pdbe-srv/view/entry/1DAF PDB 1DAG http://www.ebi.ac.uk/pdbe-srv/view/entry/1DAG PDB 1DAH http://www.ebi.ac.uk/pdbe-srv/view/entry/1DAH PDB 1DAI http://www.ebi.ac.uk/pdbe-srv/view/entry/1DAI PDB 1DAK http://www.ebi.ac.uk/pdbe-srv/view/entry/1DAK PDB 1DAM http://www.ebi.ac.uk/pdbe-srv/view/entry/1DAM PDB 1DBS http://www.ebi.ac.uk/pdbe-srv/view/entry/1DBS PDB 1DTS http://www.ebi.ac.uk/pdbe-srv/view/entry/1DTS PDBsum 1A82 http://www.ebi.ac.uk/pdbsum/1A82 PDBsum 1BS1 http://www.ebi.ac.uk/pdbsum/1BS1 PDBsum 1BYI http://www.ebi.ac.uk/pdbsum/1BYI PDBsum 1DAD http://www.ebi.ac.uk/pdbsum/1DAD PDBsum 1DAE http://www.ebi.ac.uk/pdbsum/1DAE PDBsum 1DAF http://www.ebi.ac.uk/pdbsum/1DAF PDBsum 1DAG http://www.ebi.ac.uk/pdbsum/1DAG PDBsum 1DAH http://www.ebi.ac.uk/pdbsum/1DAH PDBsum 1DAI http://www.ebi.ac.uk/pdbsum/1DAI PDBsum 1DAK http://www.ebi.ac.uk/pdbsum/1DAK PDBsum 1DAM http://www.ebi.ac.uk/pdbsum/1DAM PDBsum 1DBS http://www.ebi.ac.uk/pdbsum/1DBS PDBsum 1DTS http://www.ebi.ac.uk/pdbsum/1DTS PSORT swissprot:BIOD1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BIOD1_ECOLI PSORT-B swissprot:BIOD1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BIOD1_ECOLI PSORT2 swissprot:BIOD1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BIOD1_ECOLI Phobius swissprot:BIOD1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BIOD1_ECOLI PhylomeDB P13000 http://phylomedb.org/?seqid=P13000 ProteinModelPortal P13000 http://www.proteinmodelportal.org/query/uniprot/P13000 PubMed 10089457 http://www.ncbi.nlm.nih.gov/pubmed/10089457 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3058702 http://www.ncbi.nlm.nih.gov/pubmed/3058702 PubMed 4892372 http://www.ncbi.nlm.nih.gov/pubmed/4892372 PubMed 4921568 http://www.ncbi.nlm.nih.gov/pubmed/4921568 PubMed 7669756 http://www.ncbi.nlm.nih.gov/pubmed/7669756 PubMed 7881906 http://www.ncbi.nlm.nih.gov/pubmed/7881906 PubMed 8081756 http://www.ncbi.nlm.nih.gov/pubmed/8081756 PubMed 8289297 http://www.ncbi.nlm.nih.gov/pubmed/8289297 PubMed 9125495 http://www.ncbi.nlm.nih.gov/pubmed/9125495 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9576910 http://www.ncbi.nlm.nih.gov/pubmed/9576910 PubMed 9865950 http://www.ncbi.nlm.nih.gov/pubmed/9865950 RefSeq NP_415299 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415299 RefSeq WP_000044843 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000044843 SMR P13000 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P13000 STRING 511145.b0778 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0778&targetmode=cogs STRING COG0132 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0132&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TIGRFAMs TIGR00347 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00347 UniProtKB BIOD1_ECOLI http://www.uniprot.org/uniprot/BIOD1_ECOLI UniProtKB-AC P13000 http://www.uniprot.org/uniprot/P13000 charge swissprot:BIOD1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BIOD1_ECOLI eggNOG COG0132 http://eggnogapi.embl.de/nog_data/html/tree/COG0132 eggNOG ENOG4105E78 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105E78 epestfind swissprot:BIOD1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BIOD1_ECOLI garnier swissprot:BIOD1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BIOD1_ECOLI helixturnhelix swissprot:BIOD1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BIOD1_ECOLI hmoment swissprot:BIOD1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BIOD1_ECOLI iep swissprot:BIOD1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BIOD1_ECOLI inforesidue swissprot:BIOD1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BIOD1_ECOLI octanol swissprot:BIOD1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BIOD1_ECOLI pepcoil swissprot:BIOD1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BIOD1_ECOLI pepdigest swissprot:BIOD1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BIOD1_ECOLI pepinfo swissprot:BIOD1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BIOD1_ECOLI pepnet swissprot:BIOD1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BIOD1_ECOLI pepstats swissprot:BIOD1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BIOD1_ECOLI pepwheel swissprot:BIOD1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BIOD1_ECOLI pepwindow swissprot:BIOD1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BIOD1_ECOLI sigcleave swissprot:BIOD1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BIOD1_ECOLI ## Database ID URL or Descriptions # AltName RUSA_ECOLI Holliday junction nuclease RusA # AltName RUSA_ECOLI Holliday junction resolvase # BRENDA 3.1.22 2026 # BioGrid 4261529 59 # BioGrid 849560 4 # CATALYTIC ACTIVITY RUSA_ECOLI Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction). # COFACTOR RUSA_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000305}; Note=Binds 1 Mg(2+) ion per subunit. {ECO 0000305}; # EcoGene EG20283 rusA # FUNCTION RUSA_ECOLI Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of CC dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC. # GO_component GO:0048476 Holliday junction resolvase complex; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IEA:InterPro. # GO_function GO:0008821 crossover junction endodeoxyribonuclease activity; IDA:EcoCyc. # GO_function GO:0010844 recombination hotspot binding; IDA:EcoCyc. # GO_process GO:0006281 DNA repair; IDA:EcoCyc. # GO_process GO:0006310 DNA recombination; IEA:UniProtKB-KW. # GOslim_component GO:0043234 protein complex # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004518 nuclease activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # Gene3D 3.30.1330.70 -; 1. # InterPro IPR008822 Endonuclease_RusA-like # InterPro IPR016281 Endonuclease_RusA # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # MISCELLANEOUS RUSA_ECOLI Encoded by the cryptic lambdoid prophage DLP12. Normally not expressed. Complete suppression of ruv mutations by RusA is dependent on the activity of RecG. # Organism RUSA_ECOLI Escherichia coli (strain K12) # PATRIC 32116262 VBIEscCol129921_0571 # PDB 1Q8R X-ray; 1.90 A; A/B=1-120 # PDB 2H8C X-ray; 3.10 A; A/B/C/D=1-120 # PDB 2H8E X-ray; 1.20 A; A=1-120 # PIR S66590 S66590 # PIRSF PIRSF001007 RusA # Pfam PF05866 RusA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RUSA_ECOLI Crossover junction endodeoxyribonuclease RusA # RefSeq NP_415082 NC_000913.3 # RefSeq WP_001099712 NZ_LN832404.1 # SIMILARITY Belongs to the RusA family. {ECO 0000305}. # SUBUNIT RUSA_ECOLI Homodimer. {ECO 0000269|PubMed 14656440, ECO 0000269|PubMed 17028102, ECO 0000269|PubMed 9169457}. # SUPFAM SSF103084 SSF103084 # eggNOG COG4570 LUCA # eggNOG ENOG4106CZA Bacteria BLAST swissprot:RUSA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RUSA_ECOLI BioCyc ECOL316407:JW0538-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0538-MONOMER BioCyc EcoCyc:G6306-MONOMER http://biocyc.org/getid?id=EcoCyc:G6306-MONOMER DIP DIP-16988N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-16988N DOI 10.1006/jmbi.1996.0185 http://dx.doi.org/10.1006/jmbi.1996.0185 DOI 10.1006/jmbi.1998.1681 http://dx.doi.org/10.1006/jmbi.1998.1681 DOI 10.1006/jmbi.1998.2499 http://dx.doi.org/10.1006/jmbi.1998.2499 DOI 10.1006/jmbi.2000.4196 http://dx.doi.org/10.1006/jmbi.2000.4196 DOI 10.1016/j.str.2003.11.004 http://dx.doi.org/10.1016/j.str.2003.11.004 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.272.23.14873 http://dx.doi.org/10.1074/jbc.272.23.14873 DOI 10.1093/nar/gkl447 http://dx.doi.org/10.1093/nar/gkl447 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.22.4 http://www.genome.jp/dbget-bin/www_bget?EC:3.1.22.4 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EMBL X92587 http://www.ebi.ac.uk/ena/data/view/X92587 ENZYME 3.1.22.4 http://enzyme.expasy.org/EC/3.1.22.4 EchoBASE EB4170 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4170 EcoGene EG20283 http://www.ecogene.org/geneInfo.php?eg_id=EG20283 EnsemblBacteria AAC73651 http://www.ensemblgenomes.org/id/AAC73651 EnsemblBacteria AAC73651 http://www.ensemblgenomes.org/id/AAC73651 EnsemblBacteria BAE76325 http://www.ensemblgenomes.org/id/BAE76325 EnsemblBacteria BAE76325 http://www.ensemblgenomes.org/id/BAE76325 EnsemblBacteria BAE76325 http://www.ensemblgenomes.org/id/BAE76325 EnsemblBacteria b0550 http://www.ensemblgenomes.org/id/b0550 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0048476 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048476 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0008821 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008821 GO_function GO:0010844 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010844 GO_process GO:0006281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006281 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.30.1330.70 http://www.cathdb.info/version/latest/superfamily/3.30.1330.70 GeneID 945174 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945174 HOGENOM HOG000119986 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000119986&db=HOGENOM6 InParanoid P0AG74 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AG74 IntAct P0AG74 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AG74* IntEnz 3.1.22.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.22.4 InterPro IPR008822 http://www.ebi.ac.uk/interpro/entry/IPR008822 InterPro IPR016281 http://www.ebi.ac.uk/interpro/entry/IPR016281 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW0538 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0538 KEGG_Gene eco:b0550 http://www.genome.jp/dbget-bin/www_bget?eco:b0550 KEGG_Orthology KO:K01160 http://www.genome.jp/dbget-bin/www_bget?KO:K01160 OMA IHYISDW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=IHYISDW PDB 1Q8R http://www.ebi.ac.uk/pdbe-srv/view/entry/1Q8R PDB 2H8C http://www.ebi.ac.uk/pdbe-srv/view/entry/2H8C PDB 2H8E http://www.ebi.ac.uk/pdbe-srv/view/entry/2H8E PDBsum 1Q8R http://www.ebi.ac.uk/pdbsum/1Q8R PDBsum 2H8C http://www.ebi.ac.uk/pdbsum/2H8C PDBsum 2H8E http://www.ebi.ac.uk/pdbsum/2H8E PSORT swissprot:RUSA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RUSA_ECOLI PSORT-B swissprot:RUSA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RUSA_ECOLI PSORT2 swissprot:RUSA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RUSA_ECOLI Pfam PF05866 http://pfam.xfam.org/family/PF05866 Phobius swissprot:RUSA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RUSA_ECOLI ProteinModelPortal P0AG74 http://www.proteinmodelportal.org/query/uniprot/P0AG74 PubMed 11080453 http://www.ncbi.nlm.nih.gov/pubmed/11080453 PubMed 14656440 http://www.ncbi.nlm.nih.gov/pubmed/14656440 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17028102 http://www.ncbi.nlm.nih.gov/pubmed/17028102 PubMed 7813450 http://www.ncbi.nlm.nih.gov/pubmed/7813450 PubMed 8648624 http://www.ncbi.nlm.nih.gov/pubmed/8648624 PubMed 9169457 http://www.ncbi.nlm.nih.gov/pubmed/9169457 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9571038 http://www.ncbi.nlm.nih.gov/pubmed/9571038 PubMed 9973560 http://www.ncbi.nlm.nih.gov/pubmed/9973560 RefSeq NP_415082 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415082 RefSeq WP_001099712 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001099712 SMR P0AG74 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AG74 STRING 511145.b0550 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0550&targetmode=cogs SUPFAM SSF103084 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103084 UniProtKB RUSA_ECOLI http://www.uniprot.org/uniprot/RUSA_ECOLI UniProtKB-AC P0AG74 http://www.uniprot.org/uniprot/P0AG74 charge swissprot:RUSA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RUSA_ECOLI eggNOG COG4570 http://eggnogapi.embl.de/nog_data/html/tree/COG4570 eggNOG ENOG4106CZA http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106CZA epestfind swissprot:RUSA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RUSA_ECOLI garnier swissprot:RUSA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RUSA_ECOLI helixturnhelix swissprot:RUSA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RUSA_ECOLI hmoment swissprot:RUSA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RUSA_ECOLI iep swissprot:RUSA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RUSA_ECOLI inforesidue swissprot:RUSA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RUSA_ECOLI octanol swissprot:RUSA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RUSA_ECOLI pepcoil swissprot:RUSA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RUSA_ECOLI pepdigest swissprot:RUSA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RUSA_ECOLI pepinfo swissprot:RUSA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RUSA_ECOLI pepnet swissprot:RUSA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RUSA_ECOLI pepstats swissprot:RUSA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RUSA_ECOLI pepwheel swissprot:RUSA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RUSA_ECOLI pepwindow swissprot:RUSA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RUSA_ECOLI sigcleave swissprot:RUSA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RUSA_ECOLI ## Database ID URL or Descriptions # EcoGene EG14460 yciZ # HAMAP MF_01641 UPF0509 # InterPro IPR020887 UPF0509 # Organism YCIZ_ECOLI Escherichia coli (strain K12) # PATRIC 32117834 VBIEscCol129921_1337 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YCIZ_ECOLI UPF0509 protein YciZ # RefSeq WP_001288368 NZ_LN832404.1 # RefSeq YP_001165317 NC_000913.3 # SIMILARITY Belongs to the UPF0509 family. {ECO 0000305}. # eggNOG ENOG410643D Bacteria # eggNOG ENOG4112CHN LUCA BLAST swissprot:YCIZ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCIZ_ECOLI BioCyc EcoCyc:MONOMER0-2820 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2820 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EcoGene EG14460 http://www.ecogene.org/geneInfo.php?eg_id=EG14460 EnsemblBacteria ABP93443 http://www.ensemblgenomes.org/id/ABP93443 EnsemblBacteria ABP93443 http://www.ensemblgenomes.org/id/ABP93443 EnsemblBacteria b4596 http://www.ensemblgenomes.org/id/b4596 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 5061509 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5061509 HAMAP MF_01641 http://hamap.expasy.org/unirule/MF_01641 HOGENOM HOG000267926 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000267926&db=HOGENOM6 InterPro IPR020887 http://www.ebi.ac.uk/interpro/entry/IPR020887 KEGG_Gene eco:b4596 http://www.genome.jp/dbget-bin/www_bget?eco:b4596 OMA PKSPWEI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PKSPWEI PSORT swissprot:YCIZ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCIZ_ECOLI PSORT-B swissprot:YCIZ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCIZ_ECOLI PSORT2 swissprot:YCIZ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCIZ_ECOLI Phobius swissprot:YCIZ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCIZ_ECOLI ProteinModelPortal A5A614 http://www.proteinmodelportal.org/query/uniprot/A5A614 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001288368 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001288368 RefSeq YP_001165317 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_001165317 STRING 511145.b4596 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4596&targetmode=cogs UniProtKB YCIZ_ECOLI http://www.uniprot.org/uniprot/YCIZ_ECOLI UniProtKB-AC A5A614 http://www.uniprot.org/uniprot/A5A614 charge swissprot:YCIZ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCIZ_ECOLI eggNOG ENOG410643D http://eggnogapi.embl.de/nog_data/html/tree/ENOG410643D eggNOG ENOG4112CHN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4112CHN epestfind swissprot:YCIZ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCIZ_ECOLI garnier swissprot:YCIZ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCIZ_ECOLI helixturnhelix swissprot:YCIZ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCIZ_ECOLI hmoment swissprot:YCIZ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCIZ_ECOLI iep swissprot:YCIZ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCIZ_ECOLI inforesidue swissprot:YCIZ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCIZ_ECOLI octanol swissprot:YCIZ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCIZ_ECOLI pepcoil swissprot:YCIZ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCIZ_ECOLI pepdigest swissprot:YCIZ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCIZ_ECOLI pepinfo swissprot:YCIZ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCIZ_ECOLI pepnet swissprot:YCIZ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCIZ_ECOLI pepstats swissprot:YCIZ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCIZ_ECOLI pepwheel swissprot:YCIZ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCIZ_ECOLI pepwindow swissprot:YCIZ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCIZ_ECOLI sigcleave swissprot:YCIZ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCIZ_ECOLI ## Database ID URL or Descriptions # BioGrid 4261090 8 # CATALYTIC ACTIVITY ATP + H(2)O + taurine(Out) = ADP + phosphate + taurine(In). {ECO:0000255|HAMAP-Rule MF_01714}. # EcoGene EG13299 tauB # FUNCTION TAUB_ECOLI Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system. {ECO 0000255|HAMAP-Rule MF_01714, ECO 0000269|PubMed 10781534, ECO 0000269|PubMed 8808933}. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; IEA:UniProtKB-HAMAP. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0015411 taurine-transporting ATPase activity; IEA:UniProtKB-HAMAP. # GO_process GO:0010438 cellular response to sulfur starvation; IEP:EcoCyc. # GO_process GO:0015734 taurine transport; IEA:UniProtKB-HAMAP. # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # GOslim_process GO:0006950 response to stress # Gene3D 3.40.50.300 -; 1. # INDUCTION Regulated by CysB in response to sulfate starvation. {ECO:0000269|PubMed 8808933}. # IntAct Q47538 4 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR015859 ABC_transpr_TauD # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko02000 M00435 Taurine transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism TAUB_ECOLI Escherichia coli (strain K12) # PATRIC 32115871 VBIEscCol129921_0377 # PIR S78605 F64764 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # PROSITE PS51250 TAUB # Pfam PF00005 ABC_tran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Taurine import ATP-binding protein TauB {ECO:0000255|HAMAP-Rule MF_01714} # RefSeq NP_414900 NC_000913.3 # RefSeq WP_000939375 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. Taurine importer (TC 3.A.1.17.1) family. {ECO:0000255|HAMAP- Rule MF_01714}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|HAMAP- Rule MF_01714}. # SMART SM00382 AAA # SUBCELLULAR LOCATION TAUB_ECOLI Cell inner membrane {ECO 0000255|HAMAP- Rule MF_01714}; Peripheral membrane protein {ECO 0000255|HAMAP- Rule MF_01714}. # SUBUNIT The complex is composed of two ATP-binding proteins (TauB), two transmembrane proteins (TauC) and a solute-binding protein (TauA). {ECO:0000255|HAMAP-Rule MF_01714}. # SUPFAM SSF52540 SSF52540 # TCDB 3.A.1.17 the atp-binding cassette (abc) superfamily # eggNOG COG4525 LUCA # eggNOG ENOG4108IY8 Bacteria BLAST swissprot:TAUB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TAUB_ECOLI BioCyc ECOL316407:JW0358-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0358-MONOMER BioCyc EcoCyc:TAUB-MONOMER http://biocyc.org/getid?id=EcoCyc:TAUB-MONOMER BioCyc MetaCyc:TAUB-MONOMER http://biocyc.org/getid?id=MetaCyc:TAUB-MONOMER COG COG4525 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4525 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.182.10.2687-2695.2000 http://dx.doi.org/10.1128/JB.182.10.2687-2695.2000 EC_number EC:3.6.3.36 {ECO:0000255|HAMAP-Rule:MF_01714} http://www.genome.jp/dbget-bin/www_bget?EC:3.6.3.36 {ECO:0000255|HAMAP-Rule:MF_01714} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D85613 http://www.ebi.ac.uk/ena/data/view/D85613 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U73857 http://www.ebi.ac.uk/ena/data/view/U73857 ENZYME 3.6.3.36 {ECO:0000255|HAMAP-Rule:MF_01714} http://enzyme.expasy.org/EC/3.6.3.36 {ECO:0000255|HAMAP-Rule:MF_01714} EchoBASE EB3084 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3084 EcoGene EG13299 http://www.ecogene.org/geneInfo.php?eg_id=EG13299 EnsemblBacteria AAC73469 http://www.ensemblgenomes.org/id/AAC73469 EnsemblBacteria AAC73469 http://www.ensemblgenomes.org/id/AAC73469 EnsemblBacteria BAE76147 http://www.ensemblgenomes.org/id/BAE76147 EnsemblBacteria BAE76147 http://www.ensemblgenomes.org/id/BAE76147 EnsemblBacteria BAE76147 http://www.ensemblgenomes.org/id/BAE76147 EnsemblBacteria b0366 http://www.ensemblgenomes.org/id/b0366 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0015411 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015411 GO_process GO:0010438 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010438 GO_process GO:0015734 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015734 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945027 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945027 InParanoid Q47538 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q47538 IntAct Q47538 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q47538* IntEnz 3.6.3.36 {ECO:0000255|HAMAP-Rule:MF_01714} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.6.3.36 {ECO:0000255|HAMAP-Rule:MF_01714} InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR015859 http://www.ebi.ac.uk/interpro/entry/IPR015859 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0358 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0358 KEGG_Gene eco:b0366 http://www.genome.jp/dbget-bin/www_bget?eco:b0366 KEGG_Orthology KO:K10831 http://www.genome.jp/dbget-bin/www_bget?KO:K10831 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA NISKVFR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=NISKVFR PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PROSITE PS51250 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51250 PSORT swissprot:TAUB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TAUB_ECOLI PSORT-B swissprot:TAUB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TAUB_ECOLI PSORT2 swissprot:TAUB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TAUB_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Phobius swissprot:TAUB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TAUB_ECOLI PhylomeDB Q47538 http://phylomedb.org/?seqid=Q47538 ProteinModelPortal Q47538 http://www.proteinmodelportal.org/query/uniprot/Q47538 PubMed 10781534 http://www.ncbi.nlm.nih.gov/pubmed/10781534 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8808933 http://www.ncbi.nlm.nih.gov/pubmed/8808933 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414900 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414900 RefSeq WP_000939375 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000939375 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR Q47538 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q47538 STRING 511145.b0366 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0366&targetmode=cogs STRING COG4525 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4525&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.17 http://www.tcdb.org/search/result.php?tc=3.A.1.17 UniProtKB TAUB_ECOLI http://www.uniprot.org/uniprot/TAUB_ECOLI UniProtKB-AC Q47538 http://www.uniprot.org/uniprot/Q47538 charge swissprot:TAUB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TAUB_ECOLI eggNOG COG4525 http://eggnogapi.embl.de/nog_data/html/tree/COG4525 eggNOG ENOG4108IY8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108IY8 epestfind swissprot:TAUB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TAUB_ECOLI garnier swissprot:TAUB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TAUB_ECOLI helixturnhelix swissprot:TAUB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TAUB_ECOLI hmoment swissprot:TAUB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TAUB_ECOLI iep swissprot:TAUB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TAUB_ECOLI inforesidue swissprot:TAUB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TAUB_ECOLI octanol swissprot:TAUB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TAUB_ECOLI pepcoil swissprot:TAUB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TAUB_ECOLI pepdigest swissprot:TAUB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TAUB_ECOLI pepinfo swissprot:TAUB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TAUB_ECOLI pepnet swissprot:TAUB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TAUB_ECOLI pepstats swissprot:TAUB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TAUB_ECOLI pepwheel swissprot:TAUB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TAUB_ECOLI pepwindow swissprot:TAUB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TAUB_ECOLI sigcleave swissprot:TAUB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TAUB_ECOLI ## Database ID URL or Descriptions # AltName SYH_ECOLI Histidyl-tRNA synthetase # BRENDA 6.1.1.21 2026 # BioGrid 4260589 29 # CATALYTIC ACTIVITY SYH_ECOLI ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). # CDD cd00859 HisRS_anticodon # EcoGene EG10453 hisS # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004821 histidine-tRNA ligase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006427 histidyl-tRNA aminoacylation; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0006520 cellular amino acid metabolic process # Gene3D 3.40.50.800 -; 1. # HAMAP MF_00127 His_tRNA_synth # IntAct P60906 2 # InterPro IPR004154 Anticodon-bd # InterPro IPR004516 HisRS/HisZ # InterPro IPR006195 aa-tRNA-synth_II # InterPro IPR015807 His-tRNA-ligase # InterPro IPR033656 HisRS_anticodon # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko01007 Amino acid related enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # KEGG_Pathway ko00970 Aminoacyl-tRNA biosynthesis # Organism SYH_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11476 PTHR11476 # PATRIC 32120421 VBIEscCol129921_2613 # PDB 1HTT X-ray; 2.60 A; A/B/C/D=2-424 # PDB 1KMM X-ray; 2.60 A; A/B/C/D=1-424 # PDB 1KMN X-ray; 2.80 A; A/B/C/D=1-424 # PDB 2EL9 X-ray; 2.70 A; A/B/C/D=1-424 # PIR A23890 SYECH # PIRSF PIRSF001549 His-tRNA_synth # PROSITE PS50862 AA_TRNA_LIGASE_II # Pfam PF03129 HGTP_anticodon # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SYH_ECOLI Histidine--tRNA ligase # RefSeq NP_417009 NC_000913.3 # RefSeq WP_001107167 NZ_LN832404.1 # SIMILARITY Belongs to the class-II aminoacyl-tRNA synthetase family. {ECO 0000305}. # SUBCELLULAR LOCATION SYH_ECOLI Cytoplasm. # SUBUNIT SYH_ECOLI Homodimer. # SUPFAM SSF52954 SSF52954 # TIGRFAMs TIGR00442 hisS # eggNOG COG0124 LUCA # eggNOG ENOG4105CUT Bacteria BLAST swissprot:SYH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SYH_ECOLI BioCyc ECOL316407:JW2498-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2498-MONOMER BioCyc EcoCyc:HISS-MONOMER http://biocyc.org/getid?id=EcoCyc:HISS-MONOMER BioCyc MetaCyc:HISS-MONOMER http://biocyc.org/getid?id=MetaCyc:HISS-MONOMER COG COG0124 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0124 DIP DIP-35894N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35894N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1016/0378-1119(82)90108-1 http://dx.doi.org/10.1016/0378-1119(82)90108-1 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.94.14.7144 http://dx.doi.org/10.1073/pnas.94.14.7144 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:6.1.1.21 http://www.genome.jp/dbget-bin/www_bget?EC:6.1.1.21 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M11843 http://www.ebi.ac.uk/ena/data/view/M11843 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 6.1.1.21 http://enzyme.expasy.org/EC/6.1.1.21 EchoBASE EB0448 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0448 EcoGene EG10453 http://www.ecogene.org/geneInfo.php?eg_id=EG10453 EnsemblBacteria AAC75567 http://www.ensemblgenomes.org/id/AAC75567 EnsemblBacteria AAC75567 http://www.ensemblgenomes.org/id/AAC75567 EnsemblBacteria BAA16401 http://www.ensemblgenomes.org/id/BAA16401 EnsemblBacteria BAA16401 http://www.ensemblgenomes.org/id/BAA16401 EnsemblBacteria BAA16401 http://www.ensemblgenomes.org/id/BAA16401 EnsemblBacteria b2514 http://www.ensemblgenomes.org/id/b2514 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004821 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004821 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_process GO:0006427 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006427 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 Gene3D 3.40.50.800 http://www.cathdb.info/version/latest/superfamily/3.40.50.800 GeneID 946989 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946989 HAMAP MF_00127 http://hamap.expasy.org/unirule/MF_00127 HOGENOM HOG000018072 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000018072&db=HOGENOM6 InParanoid P60906 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P60906 IntAct P60906 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P60906* IntEnz 6.1.1.21 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.1.1.21 InterPro IPR004154 http://www.ebi.ac.uk/interpro/entry/IPR004154 InterPro IPR004516 http://www.ebi.ac.uk/interpro/entry/IPR004516 InterPro IPR006195 http://www.ebi.ac.uk/interpro/entry/IPR006195 InterPro IPR015807 http://www.ebi.ac.uk/interpro/entry/IPR015807 InterPro IPR033656 http://www.ebi.ac.uk/interpro/entry/IPR033656 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko01007 http://www.genome.jp/dbget-bin/www_bget?ko01007 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW2498 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2498 KEGG_Gene eco:b2514 http://www.genome.jp/dbget-bin/www_bget?eco:b2514 KEGG_Orthology KO:K01892 http://www.genome.jp/dbget-bin/www_bget?KO:K01892 KEGG_Pathway ko00970 http://www.genome.jp/kegg-bin/show_pathway?ko00970 KEGG_Reaction rn:R03655 http://www.genome.jp/dbget-bin/www_bget?rn:R03655 MINT MINT-1236095 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1236095 OMA CGGGNFK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CGGGNFK PANTHER PTHR11476 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11476 PDB 1HTT http://www.ebi.ac.uk/pdbe-srv/view/entry/1HTT PDB 1KMM http://www.ebi.ac.uk/pdbe-srv/view/entry/1KMM PDB 1KMN http://www.ebi.ac.uk/pdbe-srv/view/entry/1KMN PDB 2EL9 http://www.ebi.ac.uk/pdbe-srv/view/entry/2EL9 PDBsum 1HTT http://www.ebi.ac.uk/pdbsum/1HTT PDBsum 1KMM http://www.ebi.ac.uk/pdbsum/1KMM PDBsum 1KMN http://www.ebi.ac.uk/pdbsum/1KMN PDBsum 2EL9 http://www.ebi.ac.uk/pdbsum/2EL9 PROSITE PS50862 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50862 PSORT swissprot:SYH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SYH_ECOLI PSORT-B swissprot:SYH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SYH_ECOLI PSORT2 swissprot:SYH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SYH_ECOLI Pfam PF03129 http://pfam.xfam.org/family/PF03129 Phobius swissprot:SYH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SYH_ECOLI PhylomeDB P60906 http://phylomedb.org/?seqid=P60906 ProteinModelPortal P60906 http://www.proteinmodelportal.org/query/uniprot/P60906 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2991272 http://www.ncbi.nlm.nih.gov/pubmed/2991272 PubMed 6290315 http://www.ncbi.nlm.nih.gov/pubmed/6290315 PubMed 7556055 http://www.ncbi.nlm.nih.gov/pubmed/7556055 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9207058 http://www.ncbi.nlm.nih.gov/pubmed/9207058 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_417009 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417009 RefSeq WP_001107167 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001107167 SMR P60906 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P60906 STRING 511145.b2514 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2514&targetmode=cogs STRING COG0124 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0124&targetmode=cogs SUPFAM SSF52954 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52954 SWISS-2DPAGE P60906 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P60906 TIGRFAMs TIGR00442 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00442 UniProtKB SYH_ECOLI http://www.uniprot.org/uniprot/SYH_ECOLI UniProtKB-AC P60906 http://www.uniprot.org/uniprot/P60906 charge swissprot:SYH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SYH_ECOLI eggNOG COG0124 http://eggnogapi.embl.de/nog_data/html/tree/COG0124 eggNOG ENOG4105CUT http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CUT epestfind swissprot:SYH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SYH_ECOLI garnier swissprot:SYH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SYH_ECOLI helixturnhelix swissprot:SYH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SYH_ECOLI hmoment swissprot:SYH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SYH_ECOLI iep swissprot:SYH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SYH_ECOLI inforesidue swissprot:SYH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SYH_ECOLI octanol swissprot:SYH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SYH_ECOLI pepcoil swissprot:SYH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SYH_ECOLI pepdigest swissprot:SYH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SYH_ECOLI pepinfo swissprot:SYH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SYH_ECOLI pepnet swissprot:SYH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SYH_ECOLI pepstats swissprot:SYH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SYH_ECOLI pepwheel swissprot:SYH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SYH_ECOLI pepwindow swissprot:SYH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SYH_ECOLI sigcleave swissprot:SYH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SYH_ECOLI ## Database ID URL or Descriptions # BioGrid 4261834 13 # EcoGene EG13674 ybhR # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0015562 efflux transmembrane transporter activity; IBA:GO_Central. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0055085 transmembrane transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006950 response to stress # GOslim_process GO:0055085 transmembrane transport # InterPro IPR000412 ABC_2_transport # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00254 ABC-2 type transport system # KEGG_Brite ko02000 Transporters # Organism YBHR_ECOLI Escherichia coli (strain K12) # PATRIC 32116785 VBIEscCol129921_0818 # PIR H64815 H64815 # PRINTS PR00164 ABC2TRNSPORT # PROSITE PS51012 ABC_TM2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBHR_ECOLI Inner membrane transport permease YbhR # RefSeq NP_415313 NC_000913.3 # RefSeq WP_000469031 NZ_LN832404.1 # SIMILARITY Belongs to the ABC-2 integral membrane protein family. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-2 domain. {ECO:0000255|PROSITE-ProRule PRU00442}. # SUBCELLULAR LOCATION YBHR_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 3.A.1.105.15 the atp-binding cassette (abc) superfamily # eggNOG COG0842 LUCA # eggNOG ENOG4107QWP Bacteria BLAST swissprot:YBHR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBHR_ECOLI BioCyc ECOL316407:JW5803-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5803-MONOMER BioCyc EcoCyc:YBHR-MONOMER http://biocyc.org/getid?id=EcoCyc:YBHR-MONOMER COG COG0842 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0842 COG COG1277 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1277 COG COG1682 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1682 COG COG3694 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3694 DIP DIP-48088N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48088N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3438 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3438 EcoGene EG13674 http://www.ecogene.org/geneInfo.php?eg_id=EG13674 EnsemblBacteria AAC73879 http://www.ensemblgenomes.org/id/AAC73879 EnsemblBacteria AAC73879 http://www.ensemblgenomes.org/id/AAC73879 EnsemblBacteria BAA35451 http://www.ensemblgenomes.org/id/BAA35451 EnsemblBacteria BAA35451 http://www.ensemblgenomes.org/id/BAA35451 EnsemblBacteria BAA35451 http://www.ensemblgenomes.org/id/BAA35451 EnsemblBacteria b0792 http://www.ensemblgenomes.org/id/b0792 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0015562 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015562 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 945403 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945403 HOGENOM HOG000270979 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000270979&db=HOGENOM6 InParanoid P0AFP9 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFP9 InterPro IPR000412 http://www.ebi.ac.uk/interpro/entry/IPR000412 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5803 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5803 KEGG_Gene eco:b0792 http://www.genome.jp/dbget-bin/www_bget?eco:b0792 KEGG_Orthology KO:K01992 http://www.genome.jp/dbget-bin/www_bget?KO:K01992 OMA SLEIVWG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SLEIVWG PRINTS PR00164 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00164 PROSITE PS51012 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51012 PSORT swissprot:YBHR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBHR_ECOLI PSORT-B swissprot:YBHR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBHR_ECOLI PSORT2 swissprot:YBHR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBHR_ECOLI Phobius swissprot:YBHR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBHR_ECOLI PhylomeDB P0AFP9 http://phylomedb.org/?seqid=P0AFP9 ProteinModelPortal P0AFP9 http://www.proteinmodelportal.org/query/uniprot/P0AFP9 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415313 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415313 RefSeq WP_000469031 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000469031 SMR P0AFP9 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFP9 STRING 511145.b0792 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0792&targetmode=cogs STRING COG0842 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0842&targetmode=cogs STRING COG1277 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1277&targetmode=cogs STRING COG1682 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1682&targetmode=cogs STRING COG3694 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3694&targetmode=cogs TCDB 3.A.1.105.15 http://www.tcdb.org/search/result.php?tc=3.A.1.105.15 UniProtKB YBHR_ECOLI http://www.uniprot.org/uniprot/YBHR_ECOLI UniProtKB-AC P0AFP9 http://www.uniprot.org/uniprot/P0AFP9 charge swissprot:YBHR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBHR_ECOLI eggNOG COG0842 http://eggnogapi.embl.de/nog_data/html/tree/COG0842 eggNOG ENOG4107QWP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QWP epestfind swissprot:YBHR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBHR_ECOLI garnier swissprot:YBHR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBHR_ECOLI helixturnhelix swissprot:YBHR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBHR_ECOLI hmoment swissprot:YBHR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBHR_ECOLI iep swissprot:YBHR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBHR_ECOLI inforesidue swissprot:YBHR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBHR_ECOLI octanol swissprot:YBHR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBHR_ECOLI pepcoil swissprot:YBHR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBHR_ECOLI pepdigest swissprot:YBHR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBHR_ECOLI pepinfo swissprot:YBHR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBHR_ECOLI pepnet swissprot:YBHR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBHR_ECOLI pepstats swissprot:YBHR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBHR_ECOLI pepwheel swissprot:YBHR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBHR_ECOLI pepwindow swissprot:YBHR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBHR_ECOLI sigcleave swissprot:YBHR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBHR_ECOLI ## Database ID URL or Descriptions # BioGrid 4262896 51 # EcoGene EG13762 ydcS # FUNCTION YDCS_ECOLI Probably part of the binding-protein-dependent transport system YdcSTUV. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0019808 polyamine binding; IEA:InterPro. # GO_process GO:0015846 polyamine transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006810 transport # IntAct P76108 19 # InterPro IPR001188 Sperm_putr-bd # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00193 Putative spermidine/putrescine transport system # KEGG_Brite ko02000 Transporters # Organism YDCS_ECOLI Escherichia coli (strain K12) # PATRIC 32118170 VBIEscCol129921_1505 # PIR C64896 C64896 # PRINTS PR00909 SPERMDNBNDNG # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDCS_ECOLI Putative ABC transporter periplasmic-binding protein YdcS # RefSeq NP_415957 NC_000913.3 # RefSeq WP_000047424 NZ_LN832404.1 # SIMILARITY Belongs to the bacterial solute-binding protein PotD/PotF family. {ECO 0000305}. # SUBCELLULAR LOCATION YDCS_ECOLI Periplasm {ECO 0000250}. # TCDB 3.A.1.11 the atp-binding cassette (abc) superfamily # eggNOG ENOG4107TYH Bacteria # eggNOG ENOG410XUAZ LUCA BLAST swissprot:YDCS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDCS_ECOLI BioCyc ECOL316407:JW1435-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1435-MONOMER BioCyc EcoCyc:YDCS-MONOMER http://biocyc.org/getid?id=EcoCyc:YDCS-MONOMER BioCyc MetaCyc:YDCS-MONOMER http://biocyc.org/getid?id=MetaCyc:YDCS-MONOMER COG COG0687 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0687 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3525 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3525 EcoGene EG13762 http://www.ecogene.org/geneInfo.php?eg_id=EG13762 EnsemblBacteria AAC74522 http://www.ensemblgenomes.org/id/AAC74522 EnsemblBacteria AAC74522 http://www.ensemblgenomes.org/id/AAC74522 EnsemblBacteria BAE76440 http://www.ensemblgenomes.org/id/BAE76440 EnsemblBacteria BAE76440 http://www.ensemblgenomes.org/id/BAE76440 EnsemblBacteria BAE76440 http://www.ensemblgenomes.org/id/BAE76440 EnsemblBacteria b1440 http://www.ensemblgenomes.org/id/b1440 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0019808 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019808 GO_process GO:0015846 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015846 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 946005 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946005 HOGENOM HOG000283673 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000283673&db=HOGENOM6 IntAct P76108 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76108* InterPro IPR001188 http://www.ebi.ac.uk/interpro/entry/IPR001188 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1435 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1435 KEGG_Gene eco:b1440 http://www.genome.jp/dbget-bin/www_bget?eco:b1440 KEGG_Orthology KO:K02055 http://www.genome.jp/dbget-bin/www_bget?KO:K02055 OMA DWVTGFE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DWVTGFE PRINTS PR00909 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00909 PSORT swissprot:YDCS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDCS_ECOLI PSORT-B swissprot:YDCS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDCS_ECOLI PSORT2 swissprot:YDCS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDCS_ECOLI Phobius swissprot:YDCS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDCS_ECOLI PhylomeDB P76108 http://phylomedb.org/?seqid=P76108 ProteinModelPortal P76108 http://www.proteinmodelportal.org/query/uniprot/P76108 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415957 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415957 RefSeq WP_000047424 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000047424 STRING 511145.b1440 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1440&targetmode=cogs STRING COG0687 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0687&targetmode=cogs TCDB 3.A.1.11 http://www.tcdb.org/search/result.php?tc=3.A.1.11 UniProtKB YDCS_ECOLI http://www.uniprot.org/uniprot/YDCS_ECOLI UniProtKB-AC P76108 http://www.uniprot.org/uniprot/P76108 charge swissprot:YDCS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDCS_ECOLI eggNOG ENOG4107TYH http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107TYH eggNOG ENOG410XUAZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XUAZ epestfind swissprot:YDCS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDCS_ECOLI garnier swissprot:YDCS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDCS_ECOLI helixturnhelix swissprot:YDCS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDCS_ECOLI hmoment swissprot:YDCS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDCS_ECOLI iep swissprot:YDCS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDCS_ECOLI inforesidue swissprot:YDCS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDCS_ECOLI octanol swissprot:YDCS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDCS_ECOLI pepcoil swissprot:YDCS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDCS_ECOLI pepdigest swissprot:YDCS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDCS_ECOLI pepinfo swissprot:YDCS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDCS_ECOLI pepnet swissprot:YDCS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDCS_ECOLI pepstats swissprot:YDCS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDCS_ECOLI pepwheel swissprot:YDCS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDCS_ECOLI pepwindow swissprot:YDCS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDCS_ECOLI sigcleave swissprot:YDCS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDCS_ECOLI ## Database ID URL or Descriptions # BioGrid 4260004 250 # EcoGene EG10012 cydC # FUNCTION CYDC_ECOLI Somehow involved in the cytochrome D branch of aerobic respiration. Seems to be a component of a transport system. # GO_component GO:0005887 integral component of plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IDA:EcoCyc. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; ISM:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016887 ATPase activity; IDA:EcoCyc. # GO_function GO:0042626 ATPase activity, coupled to transmembrane movement of substances; IDA:EcoCyc. # GO_process GO:0033228 cysteine export; IDA:EcoCyc. # GO_process GO:0034775 glutathione transmembrane transport; IDA:EcoCyc. # GO_process GO:0070453 regulation of heme biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # GOslim_process GO:0055085 transmembrane transport # Gene3D 3.40.50.300 -; 1. # IntAct P23886 5 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR011527 ABC1_TM_dom # InterPro IPR014223 ABC_CydC # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism CYDC_ECOLI Escherichia coli (strain K12) # PATRIC 32116981 VBIEscCol129921_0915 # PIR B36888 B36888 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # PROSITE PS50929 ABC_TM1F # Pfam PF00005 ABC_tran # Pfam PF00664 ABC_membrane # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CYDC_ECOLI ATP-binding/permease protein CydC # RefSeq NP_415406 NC_000913.3 # RefSeq WP_001202177 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. Cysteine exporter (TC 3.A.1.129.1) family. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA # SUBCELLULAR LOCATION CYDC_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00441, ECO 0000269|PubMed 15919996}. # SUPFAM SSF52540 SSF52540 # SUPFAM SSF90123 SSF90123 # TCDB 3.A.1.129 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR02868 CydC # eggNOG COG4987 LUCA # eggNOG ENOG4108JJ8 Bacteria BLAST swissprot:CYDC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CYDC_ECOLI BioCyc ECOL316407:JW0869-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0869-MONOMER BioCyc EcoCyc:CYDC-MONOMER http://biocyc.org/getid?id=EcoCyc:CYDC-MONOMER BioCyc MetaCyc:CYDC-MONOMER http://biocyc.org/getid?id=MetaCyc:CYDC-MONOMER COG COG4987 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4987 DIP DIP-9362N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9362N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1101/gad.7.12b.2629 http://dx.doi.org/10.1101/gad.7.12b.2629 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10383 http://www.ebi.ac.uk/ena/data/view/L10383 EMBL L21749 http://www.ebi.ac.uk/ena/data/view/L21749 EMBL L25859 http://www.ebi.ac.uk/ena/data/view/L25859 EMBL M63145 http://www.ebi.ac.uk/ena/data/view/M63145 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0012 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0012 EcoGene EG10012 http://www.ecogene.org/geneInfo.php?eg_id=EG10012 EnsemblBacteria AAC73972 http://www.ensemblgenomes.org/id/AAC73972 EnsemblBacteria AAC73972 http://www.ensemblgenomes.org/id/AAC73972 EnsemblBacteria BAA35611 http://www.ensemblgenomes.org/id/BAA35611 EnsemblBacteria BAA35611 http://www.ensemblgenomes.org/id/BAA35611 EnsemblBacteria BAA35611 http://www.ensemblgenomes.org/id/BAA35611 EnsemblBacteria b0886 http://www.ensemblgenomes.org/id/b0886 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_function GO:0042626 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042626 GO_process GO:0033228 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033228 GO_process GO:0034775 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034775 GO_process GO:0070453 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070453 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945504 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945504 InParanoid P23886 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P23886 IntAct P23886 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P23886* InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR011527 http://www.ebi.ac.uk/interpro/entry/IPR011527 InterPro IPR014223 http://www.ebi.ac.uk/interpro/entry/IPR014223 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0869 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0869 KEGG_Gene eco:b0886 http://www.genome.jp/dbget-bin/www_bget?eco:b0886 KEGG_Orthology KO:K16012 http://www.genome.jp/dbget-bin/www_bget?KO:K16012 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA FASADKI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FASADKI PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PROSITE PS50929 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50929 PSORT swissprot:CYDC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CYDC_ECOLI PSORT-B swissprot:CYDC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CYDC_ECOLI PSORT2 swissprot:CYDC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CYDC_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Pfam PF00664 http://pfam.xfam.org/family/PF00664 Phobius swissprot:CYDC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CYDC_ECOLI PhylomeDB P23886 http://phylomedb.org/?seqid=P23886 ProteinModelPortal P23886 http://www.proteinmodelportal.org/query/uniprot/P23886 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1909328 http://www.ncbi.nlm.nih.gov/pubmed/1909328 PubMed 7934832 http://www.ncbi.nlm.nih.gov/pubmed/7934832 PubMed 8276245 http://www.ncbi.nlm.nih.gov/pubmed/8276245 PubMed 8331068 http://www.ncbi.nlm.nih.gov/pubmed/8331068 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415406 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415406 RefSeq WP_001202177 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001202177 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P23886 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P23886 STRING 511145.b0886 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0886&targetmode=cogs STRING COG4987 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4987&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SUPFAM SSF90123 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90123 TCDB 3.A.1.129 http://www.tcdb.org/search/result.php?tc=3.A.1.129 TIGRFAMs TIGR02868 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02868 UniProtKB CYDC_ECOLI http://www.uniprot.org/uniprot/CYDC_ECOLI UniProtKB-AC P23886 http://www.uniprot.org/uniprot/P23886 charge swissprot:CYDC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CYDC_ECOLI eggNOG COG4987 http://eggnogapi.embl.de/nog_data/html/tree/COG4987 eggNOG ENOG4108JJ8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108JJ8 epestfind swissprot:CYDC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CYDC_ECOLI garnier swissprot:CYDC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CYDC_ECOLI helixturnhelix swissprot:CYDC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CYDC_ECOLI hmoment swissprot:CYDC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CYDC_ECOLI iep swissprot:CYDC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CYDC_ECOLI inforesidue swissprot:CYDC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CYDC_ECOLI octanol swissprot:CYDC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CYDC_ECOLI pepcoil swissprot:CYDC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CYDC_ECOLI pepdigest swissprot:CYDC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CYDC_ECOLI pepinfo swissprot:CYDC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CYDC_ECOLI pepnet swissprot:CYDC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CYDC_ECOLI pepstats swissprot:CYDC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CYDC_ECOLI pepwheel swissprot:CYDC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CYDC_ECOLI pepwindow swissprot:CYDC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CYDC_ECOLI sigcleave swissprot:CYDC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CYDC_ECOLI ## Database ID URL or Descriptions # BioGrid 4261312 15 # EcoGene EG13469 yphH # Gene3D 1.10.10.10 -; 1. # InterPro IPR000600 ROK # InterPro IPR011991 WHTH_DNA-bd_dom # Organism YPHH_ECOLI Escherichia coli (strain K12) # PATRIC 32120497 VBIEscCol129921_2651 # PIR E65032 E65032 # Pfam PF00480 ROK # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YPHH_ECOLI Uncharacterized protein YphH # RefSeq NP_417045 NC_000913.3 # RefSeq WP_001200769 NZ_LN832404.1 # SIMILARITY Belongs to the ROK (NagC/XylR) family. {ECO 0000305}. # SUPFAM SSF46785 SSF46785 # eggNOG COG1940 LUCA # eggNOG ENOG4108NZE Bacteria BLAST swissprot:YPHH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YPHH_ECOLI BioCyc ECOL316407:JW5406-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5406-MONOMER BioCyc EcoCyc:G7344-MONOMER http://biocyc.org/getid?id=EcoCyc:G7344-MONOMER DIP DIP-12833N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12833N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3242 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3242 EcoGene EG13469 http://www.ecogene.org/geneInfo.php?eg_id=EG13469 EnsemblBacteria AAC75603 http://www.ensemblgenomes.org/id/AAC75603 EnsemblBacteria AAC75603 http://www.ensemblgenomes.org/id/AAC75603 EnsemblBacteria BAA16458 http://www.ensemblgenomes.org/id/BAA16458 EnsemblBacteria BAA16458 http://www.ensemblgenomes.org/id/BAA16458 EnsemblBacteria BAA16458 http://www.ensemblgenomes.org/id/BAA16458 EnsemblBacteria b2550 http://www.ensemblgenomes.org/id/b2550 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 GeneID 947023 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947023 HOGENOM HOG000123503 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000123503&db=HOGENOM6 IntAct P76586 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76586* InterPro IPR000600 http://www.ebi.ac.uk/interpro/entry/IPR000600 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 KEGG_Gene ecj:JW5406 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5406 KEGG_Gene eco:b2550 http://www.genome.jp/dbget-bin/www_bget?eco:b2550 MINT MINT-1238797 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1238797 OMA ACDCGRY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ACDCGRY PSORT swissprot:YPHH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YPHH_ECOLI PSORT-B swissprot:YPHH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YPHH_ECOLI PSORT2 swissprot:YPHH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YPHH_ECOLI Pfam PF00480 http://pfam.xfam.org/family/PF00480 Phobius swissprot:YPHH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YPHH_ECOLI PhylomeDB P76586 http://phylomedb.org/?seqid=P76586 ProteinModelPortal P76586 http://www.proteinmodelportal.org/query/uniprot/P76586 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417045 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417045 RefSeq WP_001200769 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001200769 SMR P76586 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76586 STRING 511145.b2550 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2550&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 UniProtKB YPHH_ECOLI http://www.uniprot.org/uniprot/YPHH_ECOLI UniProtKB-AC P76586 http://www.uniprot.org/uniprot/P76586 charge swissprot:YPHH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YPHH_ECOLI eggNOG COG1940 http://eggnogapi.embl.de/nog_data/html/tree/COG1940 eggNOG ENOG4108NZE http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108NZE epestfind swissprot:YPHH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YPHH_ECOLI garnier swissprot:YPHH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YPHH_ECOLI helixturnhelix swissprot:YPHH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YPHH_ECOLI hmoment swissprot:YPHH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YPHH_ECOLI iep swissprot:YPHH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YPHH_ECOLI inforesidue swissprot:YPHH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YPHH_ECOLI octanol swissprot:YPHH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YPHH_ECOLI pepcoil swissprot:YPHH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YPHH_ECOLI pepdigest swissprot:YPHH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YPHH_ECOLI pepinfo swissprot:YPHH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YPHH_ECOLI pepnet swissprot:YPHH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YPHH_ECOLI pepstats swissprot:YPHH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YPHH_ECOLI pepwheel swissprot:YPHH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YPHH_ECOLI pepwindow swissprot:YPHH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YPHH_ECOLI sigcleave swissprot:YPHH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YPHH_ECOLI ## Database ID URL or Descriptions # BioGrid 4261678 35 # CATALYTIC ACTIVITY DPO4_ECOLI Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). # COFACTOR DPO4_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250}; Note=Binds 2 magnesium ions per subunit. {ECO 0000250}; # DOMAIN DPO4_ECOLI The catalytic core consists of fingers, palm and thumb subdomains, but the fingers and thumb subdomains are much smaller than in high-fidelity polymerases; residues from five sequence motifs of the Y-family cluster around an active site cleft that can accommodate DNA and nucleotide substrates with relaxed geometric constraints, with consequently higher rates of misincorporation and low processivity. It lacks the O helices present in high-fidelity DNA polymerases in the fingers domain (By similarity). {ECO 0000250}. # EcoGene EG13141 dinB # FUNCTION DPO4_ECOLI Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. Overexpression of polIV results in increased frameshift mutagenesis. It is required for stationary-phase adaptive mutation, which provides the bacterium with flexibility in dealing with environmental stress, enhancing long-term survival and evolutionary fitness. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. {ECO 0000269|PubMed 11080171, ECO 0000269|PubMed 11463382, ECO 0000269|PubMed 11751576, ECO 0000269|PubMed 12060704, ECO 0000269|PubMed 9391106}. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0003684 damaged DNA binding; IEA:InterPro. # GO_function GO:0003887 DNA-directed DNA polymerase activity; IDA:EcoCyc. # GO_process GO:0000731 DNA synthesis involved in DNA repair; IDA:EcoliWiki. # GO_process GO:0006261 DNA-dependent DNA replication; IEA:UniProtKB-HAMAP. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GO_process GO:0009432 SOS response; IDA:EcoCyc. # GO_process GO:0019985 translesion synthesis; IDA:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.30.1490.100 -; 1. # HAMAP MF_01113 DNApol_IV # INDUCTION DPO4_ECOLI By SOS response. A member of the dinB-yafNOP operon (PubMed 12813093). Induced by hydroxyurea (PubMed 20005847). {ECO 0000269|PubMed 12813093, ECO 0000269|PubMed 20005847}. # INTERACTION DPO4_ECOLI P0A988 dnaN; NbExp=2; IntAct=EBI-1037359, EBI-542385; P0AFF6 nusA; NbExp=3; IntAct=EBI-1037359, EBI-551571; # IntAct Q47155 3 # InterPro IPR001126 UmuC # InterPro IPR017961 DNA_pol_Y-fam_little_finger # InterPro IPR022880 DNApol_IV # InterPro IPR024728 PolY_HhH_motif # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03400 DNA repair and recombination proteins # Organism DPO4_ECOLI Escherichia coli (strain K12) # PATRIC 32115577 VBIEscCol129921_0233 # PDB 1OK7 X-ray; 1.65 A; C=336-351 # PDB 1UNN X-ray; 1.90 A; C/D=243-351 # PDB 4IR1 X-ray; 2.38 A; A/F=2-351 # PDB 4IR9 X-ray; 2.33 A; A/F=2-351 # PDB 4IRC X-ray; 2.67 A; A/F=2-341 # PDB 4IRD X-ray; 2.48 A; A/F=2-341 # PDB 4IRK X-ray; 2.32 A; A/B=2-341 # PDB 4Q43 X-ray; 2.45 A; A/F=2-351 # PDB 4Q44 X-ray; 2.71 A; A/F=2-341 # PDB 4Q45 X-ray; 2.18 A; A/F=2-341 # PDB 4R8U X-ray; 2.30 A; A=2-340, B=2-338 # PDB 5C5J X-ray; 2.10 A; A/F=2-351 # PIR H64747 H64747 # PROSITE PS50173 UMUC # Pfam PF00817 IMS # Pfam PF11798 IMS_HHH # Pfam PF11799 IMS_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DPO4_ECOLI DNA polymerase IV # RefSeq NP_414766 NC_000913.3 # RefSeq WP_001226164 NZ_LN832404.1 # SIMILARITY Belongs to the DNA polymerase type-Y family. {ECO 0000305}. # SIMILARITY Contains 1 umuC domain. {ECO 0000305}. # SUBCELLULAR LOCATION DPO4_ECOLI Cytoplasm {ECO 0000305}. # SUBUNIT Monomer. {ECO 0000305}. # SUPFAM SSF100879 SSF100879 # eggNOG COG0389 LUCA # eggNOG ENOG4105CQ3 Bacteria BLAST swissprot:DPO4_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DPO4_ECOLI BioCyc ECOL316407:JW0221-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0221-MONOMER BioCyc EcoCyc:G6115-MONOMER http://biocyc.org/getid?id=EcoCyc:G6115-MONOMER BioCyc MetaCyc:G6115-MONOMER http://biocyc.org/getid?id=MetaCyc:G6115-MONOMER COG COG0389 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0389 DOI 10.1016/0165-7992(95)90024-1 http://dx.doi.org/10.1016/0165-7992(95)90024-1 DOI 10.1016/S0092-8674(01)00509-8 http://dx.doi.org/10.1016/S0092-8674(01)00509-8 DOI 10.1016/S1097-2765(00)80376-7 http://dx.doi.org/10.1016/S1097-2765(00)80376-7 DOI 10.1016/S1097-2765(01)00204-0 http://dx.doi.org/10.1016/S1097-2765(01)00204-0 DOI 10.1016/S1369-5274(00)00255-1 http://dx.doi.org/10.1016/S1369-5274(00)00255-1 DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.092269199 http://dx.doi.org/10.1073/pnas.092269199 DOI 10.1073/pnas.77.5.2819 http://dx.doi.org/10.1073/pnas.77.5.2819 DOI 10.1073/pnas.94.25.13792 http://dx.doi.org/10.1073/pnas.94.25.13792 DOI 10.1093/embo-reports/kvf007 http://dx.doi.org/10.1093/embo-reports/kvf007 DOI 10.1093/emboj/19.22.6259 http://dx.doi.org/10.1093/emboj/19.22.6259 DOI 10.1093/emboj/cdg568 http://dx.doi.org/10.1093/emboj/cdg568 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.185.13.3972-3977.2003 http://dx.doi.org/10.1128/JB.185.13.3972-3977.2003 DOI 10.1146/annurev.biochem.71.083101.124707 http://dx.doi.org/10.1146/annurev.biochem.71.083101.124707 EC_number EC:2.7.7.7 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.7 EMBL AF483080 http://www.ebi.ac.uk/ena/data/view/AF483080 EMBL AF483081 http://www.ebi.ac.uk/ena/data/view/AF483081 EMBL AF483082 http://www.ebi.ac.uk/ena/data/view/AF483082 EMBL AF483083 http://www.ebi.ac.uk/ena/data/view/AF483083 EMBL AF483084 http://www.ebi.ac.uk/ena/data/view/AF483084 EMBL AF483085 http://www.ebi.ac.uk/ena/data/view/AF483085 EMBL AF483086 http://www.ebi.ac.uk/ena/data/view/AF483086 EMBL AF483087 http://www.ebi.ac.uk/ena/data/view/AF483087 EMBL AF483088 http://www.ebi.ac.uk/ena/data/view/AF483088 EMBL AF483089 http://www.ebi.ac.uk/ena/data/view/AF483089 EMBL AF483090 http://www.ebi.ac.uk/ena/data/view/AF483090 EMBL AF483091 http://www.ebi.ac.uk/ena/data/view/AF483091 EMBL AF483092 http://www.ebi.ac.uk/ena/data/view/AF483092 EMBL AF483093 http://www.ebi.ac.uk/ena/data/view/AF483093 EMBL AF483094 http://www.ebi.ac.uk/ena/data/view/AF483094 EMBL AF483095 http://www.ebi.ac.uk/ena/data/view/AF483095 EMBL AF483096 http://www.ebi.ac.uk/ena/data/view/AF483096 EMBL AF483097 http://www.ebi.ac.uk/ena/data/view/AF483097 EMBL AF483098 http://www.ebi.ac.uk/ena/data/view/AF483098 EMBL AF483099 http://www.ebi.ac.uk/ena/data/view/AF483099 EMBL AF483100 http://www.ebi.ac.uk/ena/data/view/AF483100 EMBL AF483101 http://www.ebi.ac.uk/ena/data/view/AF483101 EMBL AF483102 http://www.ebi.ac.uk/ena/data/view/AF483102 EMBL AF483103 http://www.ebi.ac.uk/ena/data/view/AF483103 EMBL AF483104 http://www.ebi.ac.uk/ena/data/view/AF483104 EMBL AF483105 http://www.ebi.ac.uk/ena/data/view/AF483105 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D38582 http://www.ebi.ac.uk/ena/data/view/D38582 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U70214 http://www.ebi.ac.uk/ena/data/view/U70214 ENZYME 2.7.7.7 http://enzyme.expasy.org/EC/2.7.7.7 EchoBASE EB2935 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2935 EcoGene EG13141 http://www.ecogene.org/geneInfo.php?eg_id=EG13141 EnsemblBacteria AAC73335 http://www.ensemblgenomes.org/id/AAC73335 EnsemblBacteria AAC73335 http://www.ensemblgenomes.org/id/AAC73335 EnsemblBacteria BAA77901 http://www.ensemblgenomes.org/id/BAA77901 EnsemblBacteria BAA77901 http://www.ensemblgenomes.org/id/BAA77901 EnsemblBacteria BAA77901 http://www.ensemblgenomes.org/id/BAA77901 EnsemblBacteria b0231 http://www.ensemblgenomes.org/id/b0231 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0003684 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003684 GO_function GO:0003887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003887 GO_process GO:0000731 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000731 GO_process GO:0006261 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006261 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GO_process GO:0009432 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009432 GO_process GO:0019985 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019985 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.30.1490.100 http://www.cathdb.info/version/latest/superfamily/3.30.1490.100 GeneID 944922 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944922 HAMAP MF_01113 http://hamap.expasy.org/unirule/MF_01113 InParanoid Q47155 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q47155 IntAct Q47155 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q47155* IntEnz 2.7.7.7 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.7 InterPro IPR001126 http://www.ebi.ac.uk/interpro/entry/IPR001126 InterPro IPR017961 http://www.ebi.ac.uk/interpro/entry/IPR017961 InterPro IPR022880 http://www.ebi.ac.uk/interpro/entry/IPR022880 InterPro IPR024728 http://www.ebi.ac.uk/interpro/entry/IPR024728 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW0221 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0221 KEGG_Gene eco:b0231 http://www.genome.jp/dbget-bin/www_bget?eco:b0231 KEGG_Orthology KO:K02346 http://www.genome.jp/dbget-bin/www_bget?KO:K02346 OMA HTLPWAT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=HTLPWAT PDB 1OK7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1OK7 PDB 1UNN http://www.ebi.ac.uk/pdbe-srv/view/entry/1UNN PDB 4IR1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4IR1 PDB 4IR9 http://www.ebi.ac.uk/pdbe-srv/view/entry/4IR9 PDB 4IRC http://www.ebi.ac.uk/pdbe-srv/view/entry/4IRC PDB 4IRD http://www.ebi.ac.uk/pdbe-srv/view/entry/4IRD PDB 4IRK http://www.ebi.ac.uk/pdbe-srv/view/entry/4IRK PDB 4Q43 http://www.ebi.ac.uk/pdbe-srv/view/entry/4Q43 PDB 4Q44 http://www.ebi.ac.uk/pdbe-srv/view/entry/4Q44 PDB 4Q45 http://www.ebi.ac.uk/pdbe-srv/view/entry/4Q45 PDB 4R8U http://www.ebi.ac.uk/pdbe-srv/view/entry/4R8U PDB 5C5J http://www.ebi.ac.uk/pdbe-srv/view/entry/5C5J PDBsum 1OK7 http://www.ebi.ac.uk/pdbsum/1OK7 PDBsum 1UNN http://www.ebi.ac.uk/pdbsum/1UNN PDBsum 4IR1 http://www.ebi.ac.uk/pdbsum/4IR1 PDBsum 4IR9 http://www.ebi.ac.uk/pdbsum/4IR9 PDBsum 4IRC http://www.ebi.ac.uk/pdbsum/4IRC PDBsum 4IRD http://www.ebi.ac.uk/pdbsum/4IRD PDBsum 4IRK http://www.ebi.ac.uk/pdbsum/4IRK PDBsum 4Q43 http://www.ebi.ac.uk/pdbsum/4Q43 PDBsum 4Q44 http://www.ebi.ac.uk/pdbsum/4Q44 PDBsum 4Q45 http://www.ebi.ac.uk/pdbsum/4Q45 PDBsum 4R8U http://www.ebi.ac.uk/pdbsum/4R8U PDBsum 5C5J http://www.ebi.ac.uk/pdbsum/5C5J PROSITE PS50173 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50173 PSORT swissprot:DPO4_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DPO4_ECOLI PSORT-B swissprot:DPO4_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DPO4_ECOLI PSORT2 swissprot:DPO4_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DPO4_ECOLI Pfam PF00817 http://pfam.xfam.org/family/PF00817 Pfam PF11798 http://pfam.xfam.org/family/PF11798 Pfam PF11799 http://pfam.xfam.org/family/PF11799 Phobius swissprot:DPO4_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DPO4_ECOLI PhylomeDB Q47155 http://phylomedb.org/?seqid=Q47155 ProteinModelPortal Q47155 http://www.proteinmodelportal.org/query/uniprot/Q47155 PubMed 10488344 http://www.ncbi.nlm.nih.gov/pubmed/10488344 PubMed 11080171 http://www.ncbi.nlm.nih.gov/pubmed/11080171 PubMed 11463382 http://www.ncbi.nlm.nih.gov/pubmed/11463382 PubMed 11587937 http://www.ncbi.nlm.nih.gov/pubmed/11587937 PubMed 11595180 http://www.ncbi.nlm.nih.gov/pubmed/11595180 PubMed 11751576 http://www.ncbi.nlm.nih.gov/pubmed/11751576 PubMed 12045089 http://www.ncbi.nlm.nih.gov/pubmed/12045089 PubMed 12060704 http://www.ncbi.nlm.nih.gov/pubmed/12060704 PubMed 12813093 http://www.ncbi.nlm.nih.gov/pubmed/12813093 PubMed 14592985 http://www.ncbi.nlm.nih.gov/pubmed/14592985 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 6771759 http://www.ncbi.nlm.nih.gov/pubmed/6771759 PubMed 7596361 http://www.ncbi.nlm.nih.gov/pubmed/7596361 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9391106 http://www.ncbi.nlm.nih.gov/pubmed/9391106 RefSeq NP_414766 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414766 RefSeq WP_001226164 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001226164 SMR Q47155 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q47155 STRING 511145.b0231 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0231&targetmode=cogs STRING COG0389 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0389&targetmode=cogs SUPFAM SSF100879 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF100879 UniProtKB DPO4_ECOLI http://www.uniprot.org/uniprot/DPO4_ECOLI UniProtKB-AC Q47155 http://www.uniprot.org/uniprot/Q47155 charge swissprot:DPO4_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DPO4_ECOLI eggNOG COG0389 http://eggnogapi.embl.de/nog_data/html/tree/COG0389 eggNOG ENOG4105CQ3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CQ3 epestfind swissprot:DPO4_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DPO4_ECOLI garnier swissprot:DPO4_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DPO4_ECOLI helixturnhelix swissprot:DPO4_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DPO4_ECOLI hmoment swissprot:DPO4_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DPO4_ECOLI iep swissprot:DPO4_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DPO4_ECOLI inforesidue swissprot:DPO4_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DPO4_ECOLI octanol swissprot:DPO4_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DPO4_ECOLI pepcoil swissprot:DPO4_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DPO4_ECOLI pepdigest swissprot:DPO4_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DPO4_ECOLI pepinfo swissprot:DPO4_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DPO4_ECOLI pepnet swissprot:DPO4_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DPO4_ECOLI pepstats swissprot:DPO4_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DPO4_ECOLI pepwheel swissprot:DPO4_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DPO4_ECOLI pepwindow swissprot:DPO4_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DPO4_ECOLI sigcleave swissprot:DPO4_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DPO4_ECOLI ## Database ID URL or Descriptions # BioGrid 4260252 10 # CAUTION The protein is inactive for transport, probably due to the presence of a Leu instead of a Pro at position 100. {ECO 0000305}. # EcoGene EG11658 uidB # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005215 transporter activity; IDA:EcoCyc. # GO_process GO:0006814 sodium ion transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006810 transport # InterPro IPR001927 Na/Gal_symport # InterPro IPR018043 Na/Gal_symport_CS # InterPro IPR020846 MFS_dom # KEGG_Brite ko02000 Transporters # Organism UIDB_ECOLI Escherichia coli (strain K12) # PATRIC 32118534 VBIEscCol129921_1687 # PIR B64918 B64918 # PROSITE PS00872 NA_GALACTOSIDE_SYMP # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName UIDB_ECOLI Glucuronide carrier protein homolog # RefSeq NP_416133 NC_000913.3 # RefSeq WP_001075849 NZ_LN832404.1 # SIMILARITY Belongs to the sodium:galactoside symporter (TC 2.A.2) family. {ECO 0000305}. # SUBCELLULAR LOCATION UIDB_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF103473 SSF103473 # TIGRFAMs TIGR00792 gph # eggNOG COG2211 LUCA # eggNOG ENOG4105CT4 Bacteria BLAST swissprot:UIDB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:UIDB_ECOLI BioCyc EcoCyc:UIDB-MONOMER http://biocyc.org/getid?id=EcoCyc:UIDB-MONOMER BioCyc MetaCyc:UIDB-MONOMER http://biocyc.org/getid?id=MetaCyc:UIDB-MONOMER COG COG2211 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2211 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.187.7.2377-2385.2005 http://dx.doi.org/10.1128/JB.187.7.2377-2385.2005 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1610 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1610 EcoGene EG11658 http://www.ecogene.org/geneInfo.php?eg_id=EG11658 EnsemblBacteria AAC74688 http://www.ensemblgenomes.org/id/AAC74688 EnsemblBacteria AAC74688 http://www.ensemblgenomes.org/id/AAC74688 EnsemblBacteria BAA15367 http://www.ensemblgenomes.org/id/BAA15367 EnsemblBacteria BAA15367 http://www.ensemblgenomes.org/id/BAA15367 EnsemblBacteria BAA15367 http://www.ensemblgenomes.org/id/BAA15367 EnsemblBacteria b1616 http://www.ensemblgenomes.org/id/b1616 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_process GO:0006814 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 947484 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947484 InParanoid P0CE44 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0CE44 InterPro IPR001927 http://www.ebi.ac.uk/interpro/entry/IPR001927 InterPro IPR018043 http://www.ebi.ac.uk/interpro/entry/IPR018043 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW1608 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1608 KEGG_Gene eco:b1616 http://www.genome.jp/dbget-bin/www_bget?eco:b1616 KEGG_Orthology KO:K16139 http://www.genome.jp/dbget-bin/www_bget?KO:K16139 PROSITE PS00872 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00872 PSORT swissprot:UIDB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:UIDB_ECOLI PSORT-B swissprot:UIDB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:UIDB_ECOLI PSORT2 swissprot:UIDB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:UIDB_ECOLI Phobius swissprot:UIDB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:UIDB_ECOLI ProteinModelPortal P0CE44 http://www.proteinmodelportal.org/query/uniprot/P0CE44 PubMed 15774881 http://www.ncbi.nlm.nih.gov/pubmed/15774881 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416133 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416133 RefSeq WP_001075849 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001075849 STRING 511145.b1616 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1616&targetmode=cogs STRING COG2211 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2211&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TIGRFAMs TIGR00792 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00792 UniProtKB UIDB_ECOLI http://www.uniprot.org/uniprot/UIDB_ECOLI UniProtKB-AC P0CE44 http://www.uniprot.org/uniprot/P0CE44 charge swissprot:UIDB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:UIDB_ECOLI eggNOG COG2211 http://eggnogapi.embl.de/nog_data/html/tree/COG2211 eggNOG ENOG4105CT4 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CT4 epestfind swissprot:UIDB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:UIDB_ECOLI garnier swissprot:UIDB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:UIDB_ECOLI helixturnhelix swissprot:UIDB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:UIDB_ECOLI hmoment swissprot:UIDB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:UIDB_ECOLI iep swissprot:UIDB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:UIDB_ECOLI inforesidue swissprot:UIDB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:UIDB_ECOLI octanol swissprot:UIDB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:UIDB_ECOLI pepcoil swissprot:UIDB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:UIDB_ECOLI pepdigest swissprot:UIDB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:UIDB_ECOLI pepinfo swissprot:UIDB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:UIDB_ECOLI pepnet swissprot:UIDB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:UIDB_ECOLI pepstats swissprot:UIDB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:UIDB_ECOLI pepwheel swissprot:UIDB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:UIDB_ECOLI pepwindow swissprot:UIDB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:UIDB_ECOLI sigcleave swissprot:UIDB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:UIDB_ECOLI ## Database ID URL or Descriptions # CDD cd01433 Ribosomal_L16_L10e # DrugBank DB00446 Chloramphenicol # EcoGene EG10877 rplP # FUNCTION RL16_ECOLI This protein binds directly to 23S ribosomal RNA and is located at the A site of the peptidyltransferase center. It contacts the A and P site tRNAs. It has an essential role in subunit assembly, which is not well understood. {ECO 0000269|PubMed 3298242, ECO 0000269|PubMed 8524654}. # GO_component GO:0022625 cytosolic large ribosomal subunit; IDA:EcoCyc. # GO_function GO:0000049 tRNA binding; IDA:EcoCyc. # GO_function GO:0003735 structural constituent of ribosome; IBA:GO_Central. # GO_function GO:0019843 rRNA binding; IDA:EcoCyc. # GO_process GO:0006412 translation; IEA:UniProtKB-HAMAP. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0003735 structural constituent of ribosome # GOslim_function GO:0019843 rRNA binding # GOslim_process GO:0006412 translation # Gene3D 3.90.1170.10 -; 1. # HAMAP MF_01342 Ribosomal_L16 # IntAct P0ADY7 34 # InterPro IPR000114 Ribosomal_L16 # InterPro IPR016180 Ribosomal_L10e/L16 # InterPro IPR020798 Ribosomal_L16_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko03011 M00178 Ribosome, bacteria # KEGG_Brite ko03011 Ribosome # KEGG_Pathway ko03010 Ribosome # MASS SPECTROMETRY Mass=15326.2; Method=MALDI; Range=1-136; Evidence={ECO:0000269|PubMed 10094780}; # Organism RL16_ECOLI Escherichia coli (strain K12) # PANTHER PTHR12220 PTHR12220 # PATRIC 32122058 VBIEscCol129921_3406 # PDB 2J28 EM; 8.00 A; M=1-136 # PDB 2RDO EM; 9.10 A; M=1-136 # PDB 3BBX EM; 10.00 A; M=1-136 # PDB 3J5L EM; 6.60 A; M=1-136 # PDB 3J7Z EM; 3.90 A; M=1-136 # PDB 3J8G EM; 5.00 A; M=1-136 # PDB 3J9Y EM; 3.90 A; M=1-136 # PDB 3J9Z EM; 3.60 A; LI=1-136 # PDB 3JA1 EM; 3.60 A; LO=1-136 # PDB 3JBU EM; 3.64 A; m=1-136 # PDB 3JBV EM; 3.32 A; m=1-136 # PDB 3JCD EM; 3.70 A; M=1-136 # PDB 3JCE EM; 3.20 A; M=1-136 # PDB 3JCJ EM; 3.70 A; L=1-136 # PDB 3JCN EM; 4.60 A; M=1-136 # PDB 4CSU EM; 5.50 A; M=1-136 # PDB 4U1U X-ray; 2.95 A; BM/DM=1-136 # PDB 4U1V X-ray; 3.00 A; BM/DM=1-136 # PDB 4U20 X-ray; 2.90 A; BM/DM=1-136 # PDB 4U24 X-ray; 2.90 A; BM/DM=1-136 # PDB 4U25 X-ray; 2.90 A; BM/DM=1-136 # PDB 4U26 X-ray; 2.80 A; BM/DM=1-136 # PDB 4U27 X-ray; 2.80 A; BM/DM=1-136 # PDB 4UY8 EM; 3.80 A; M=1-136 # PDB 4V47 EM; 12.30 A; AK=1-136 # PDB 4V48 EM; 11.50 A; AK=1-136 # PDB 4V4H X-ray; 3.46 A; BM/DM=1-136 # PDB 4V4Q X-ray; 3.46 A; BM/DM=1-136 # PDB 4V4V EM; 15.00 A; BK=3-133 # PDB 4V4W EM; 15.00 A; BK=3-133 # PDB 4V50 X-ray; 3.22 A; BM/DM=1-136 # PDB 4V52 X-ray; 3.21 A; BM/DM=1-136 # PDB 4V53 X-ray; 3.54 A; BM/DM=1-136 # PDB 4V54 X-ray; 3.30 A; BM/DM=1-136 # PDB 4V55 X-ray; 4.00 A; BM/DM=1-136 # PDB 4V56 X-ray; 3.93 A; BM/DM=1-136 # PDB 4V57 X-ray; 3.50 A; BM/DM=1-136 # PDB 4V5B X-ray; 3.74 A; AM/CM=1-136 # PDB 4V5H EM; 5.80 A; BM=1-136 # PDB 4V5Y X-ray; 4.45 A; BM/DM=1-136 # PDB 4V64 X-ray; 3.50 A; BM/DM=1-136 # PDB 4V65 EM; 9.00 A; BF=1-136 # PDB 4V66 EM; 9.00 A; BF=1-136 # PDB 4V69 EM; 6.70 A; BM=1-136 # PDB 4V6C X-ray; 3.19 A; BM/DM=1-136 # PDB 4V6D X-ray; 3.81 A; BM/DM=1-136 # PDB 4V6E X-ray; 3.71 A; BM/DM=1-136 # PDB 4V6K EM; 8.25 A; AN=1-136 # PDB 4V6L EM; 13.20 A; BN=1-136 # PDB 4V6M EM; 7.10 A; BM=1-136 # PDB 4V6N EM; 12.10 A; AO=1-136 # PDB 4V6O EM; 14.70 A; BO=1-136 # PDB 4V6P EM; 13.50 A; BO=1-136 # PDB 4V6Q EM; 11.50 A; BO=1-136 # PDB 4V6R EM; 11.50 A; BO=1-136 # PDB 4V6S EM; 13.10 A; AO=1-136 # PDB 4V6T EM; 8.30 A; BM=1-136 # PDB 4V6V EM; 9.80 A; BQ=1-136 # PDB 4V6Y EM; 12.00 A; BM=1-136 # PDB 4V6Z EM; 12.00 A; BM=1-136 # PDB 4V70 EM; 17.00 A; BM=1-136 # PDB 4V71 EM; 20.00 A; BM=1-136 # PDB 4V72 EM; 13.00 A; BM=1-136 # PDB 4V73 EM; 15.00 A; BM=1-136 # PDB 4V74 EM; 17.00 A; BM=1-136 # PDB 4V75 EM; 12.00 A; BM=1-136 # PDB 4V76 EM; 17.00 A; BM=1-136 # PDB 4V77 EM; 17.00 A; BM=1-136 # PDB 4V78 EM; 20.00 A; BM=1-136 # PDB 4V79 EM; 15.00 A; BM=1-136 # PDB 4V7A EM; 9.00 A; BM=1-136 # PDB 4V7B EM; 6.80 A; BM=1-136 # PDB 4V7C EM; 7.60 A; BO=1-136 # PDB 4V7D EM; 7.60 A; AP=1-136 # PDB 4V7I EM; 9.60 A; AM=1-136 # PDB 4V7S X-ray; 3.25 A; BM/DM=1-136 # PDB 4V7T X-ray; 3.19 A; BM/DM=1-136 # PDB 4V7U X-ray; 3.10 A; BM/DM=1-136 # PDB 4V7V X-ray; 3.29 A; BM/DM=1-136 # PDB 4V85 X-ray; 3.20 A; Q=1-136 # PDB 4V89 X-ray; 3.70 A; BQ=1-136 # PDB 4V9C X-ray; 3.30 A; BM/DM=1-136 # PDB 4V9D X-ray; 3.00 A; CM/DM=1-136 # PDB 4V9O X-ray; 2.90 A; AM/CM/EM/GM=1-136 # PDB 4V9P X-ray; 2.90 A; AM/CM/EM/GM=1-136 # PDB 4WF1 X-ray; 3.09 A; BM/DM=1-136 # PDB 4WOI X-ray; 3.00 A; BM/CM=1-136 # PDB 4WWW X-ray; 3.10 A; RM/YM=1-136 # PDB 4YBB X-ray; 2.10 A; CN/DN=1-136 # PDB 5ADY EM; 4.50 A; M=1-136 # PDB 5AFI EM; 2.90 A; M=1-136 # PDB 5AKA EM; 5.70 A; M=1-136 # PDB 5GAD EM; 3.70 A; N=1-136 # PDB 5GAE EM; 3.33 A; N=1-136 # PDB 5GAF EM; 4.30 A; N=1-136 # PDB 5GAG EM; 3.80 A; N=1-136 # PDB 5GAH EM; 3.80 A; N=1-136 # PDB 5IQR EM; 3.00 A; M=1-136 # PDB 5IT8 X-ray; 3.12 A; CN/DN=1-136 # PDB 5J5B X-ray; 2.80 A; CN/DN=1-136 # PDB 5J7L X-ray; 3.00 A; CN/DN=1-136 # PDB 5J88 X-ray; 3.32 A; CN/DN=1-136 # PDB 5J8A X-ray; 3.10 A; CN/DN=1-136 # PDB 5J91 X-ray; 2.96 A; CN/DN=1-136 # PDB 5JC9 X-ray; 3.03 A; CN/DN=1-136 # PDB 5JTE EM; 3.60 A; BM=1-136 # PDB 5JU8 EM; 3.60 A; BM=1-136 # PDB 5KCR EM; 3.60 A; 1Q=1-136 # PDB 5KCS EM; 3.90 A; 1Q=1-136 # PDB 5KPS EM; 3.90 A; M=1-136 # PDB 5KPV EM; 4.10 A; L=1-136 # PDB 5KPW EM; 3.90 A; L=1-136 # PDB 5KPX EM; 3.90 A; L=1-136 # PDB 5L3P EM; 3.70 A; Q=1-136 # PIR I23129 R5EC16 # PRINTS PR00060 RIBOSOMALL16 # PROSITE PS00586 RIBOSOMAL_L16_1 # PROSITE PS00701 RIBOSOMAL_L16_2 # PTM RL16_ECOLI Is hydroxylated on Arg-81 by RoxA. The modification is nearly suppressed when E.coli is grown in anoxia. {ECO 0000269|PubMed 23103944}. # Pfam PF00252 Ribosomal_L16 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RL16_ECOLI 50S ribosomal protein L16 # RefSeq NP_417772 NC_000913.3 # RefSeq WP_000941212 NZ_LN832404.1 # SIMILARITY Belongs to the ribosomal protein L16P family. {ECO 0000305}. # SUBUNIT Part of the 50S ribosomal subunit. Cross-links to the A and P site tRNAs. {ECO:0000269|PubMed 8524654}. # SUPFAM SSF54686 SSF54686 # TIGRFAMs TIGR01164 rplP_bact # eggNOG COG0197 LUCA # eggNOG ENOG4108R70 Bacteria BLAST swissprot:RL16_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RL16_ECOLI BioCyc ECOL316407:JW3275-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3275-MONOMER BioCyc EcoCyc:EG10877-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10877-MONOMER BioCyc MetaCyc:EG10877-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10877-MONOMER COG COG0197 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0197 DIP DIP-35976N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35976N DOI 10.1006/abio.1998.3077 http://dx.doi.org/10.1006/abio.1998.3077 DOI 10.1016/0014-5793(76)80415-2 http://dx.doi.org/10.1016/0014-5793(76)80415-2 DOI 10.1016/S0092-8674(03)00427-6 http://dx.doi.org/10.1016/S0092-8674(03)00427-6 DOI 10.1016/j.celrep.2014.09.011 http://dx.doi.org/10.1016/j.celrep.2014.09.011 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nchembio.1093 http://dx.doi.org/10.1038/nchembio.1093 DOI 10.1093/nar/13.12.4521 http://dx.doi.org/10.1093/nar/13.12.4521 DOI 10.1093/nar/23.22.4635 http://dx.doi.org/10.1093/nar/23.22.4635 DOI 10.1126/science.1117230 http://dx.doi.org/10.1126/science.1117230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pbio.1001866 http://dx.doi.org/10.1371/journal.pbio.1001866 DrugBank DB00446 http://www.drugbank.ca/drugs/DB00446 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M12490 http://www.ebi.ac.uk/ena/data/view/M12490 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EMBL X02613 http://www.ebi.ac.uk/ena/data/view/X02613 EchoBASE EB0870 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0870 EcoGene EG10877 http://www.ecogene.org/geneInfo.php?eg_id=EG10877 EnsemblBacteria AAC76338 http://www.ensemblgenomes.org/id/AAC76338 EnsemblBacteria AAC76338 http://www.ensemblgenomes.org/id/AAC76338 EnsemblBacteria BAE77978 http://www.ensemblgenomes.org/id/BAE77978 EnsemblBacteria BAE77978 http://www.ensemblgenomes.org/id/BAE77978 EnsemblBacteria BAE77978 http://www.ensemblgenomes.org/id/BAE77978 EnsemblBacteria b3313 http://www.ensemblgenomes.org/id/b3313 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0022625 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022625 GO_function GO:0000049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000049 GO_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GO_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GO_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0003735 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003735 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GOslim_process GO:0006412 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006412 Gene3D 3.90.1170.10 http://www.cathdb.info/version/latest/superfamily/3.90.1170.10 GeneID 947806 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947806 HAMAP MF_01342 http://hamap.expasy.org/unirule/MF_01342 HOGENOM HOG000164573 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000164573&db=HOGENOM6 InParanoid P0ADY7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADY7 IntAct P0ADY7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ADY7* InterPro IPR000114 http://www.ebi.ac.uk/interpro/entry/IPR000114 InterPro IPR016180 http://www.ebi.ac.uk/interpro/entry/IPR016180 InterPro IPR020798 http://www.ebi.ac.uk/interpro/entry/IPR020798 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Brite ko03011 http://www.genome.jp/dbget-bin/www_bget?ko03011 KEGG_Gene ecj:JW3275 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3275 KEGG_Gene eco:b3313 http://www.genome.jp/dbget-bin/www_bget?eco:b3313 KEGG_Orthology KO:K02878 http://www.genome.jp/dbget-bin/www_bget?KO:K02878 KEGG_Pathway ko03010 http://www.genome.jp/kegg-bin/show_pathway?ko03010 MINT MINT-1302401 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1302401 OMA KGAVEYW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KGAVEYW PANTHER PTHR12220 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12220 PDB 2J28 http://www.ebi.ac.uk/pdbe-srv/view/entry/2J28 PDB 2RDO http://www.ebi.ac.uk/pdbe-srv/view/entry/2RDO PDB 3BBX http://www.ebi.ac.uk/pdbe-srv/view/entry/3BBX PDB 3J5L http://www.ebi.ac.uk/pdbe-srv/view/entry/3J5L PDB 3J7Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J7Z PDB 3J8G http://www.ebi.ac.uk/pdbe-srv/view/entry/3J8G PDB 3J9Y http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Y PDB 3J9Z http://www.ebi.ac.uk/pdbe-srv/view/entry/3J9Z PDB 3JA1 http://www.ebi.ac.uk/pdbe-srv/view/entry/3JA1 PDB 3JBU http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBU PDB 3JBV http://www.ebi.ac.uk/pdbe-srv/view/entry/3JBV PDB 3JCD http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCD PDB 3JCE http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCE PDB 3JCJ http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCJ PDB 3JCN http://www.ebi.ac.uk/pdbe-srv/view/entry/3JCN PDB 4CSU http://www.ebi.ac.uk/pdbe-srv/view/entry/4CSU PDB 4U1U http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1U PDB 4U1V http://www.ebi.ac.uk/pdbe-srv/view/entry/4U1V PDB 4U20 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U20 PDB 4U24 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U24 PDB 4U25 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U25 PDB 4U26 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U26 PDB 4U27 http://www.ebi.ac.uk/pdbe-srv/view/entry/4U27 PDB 4UY8 http://www.ebi.ac.uk/pdbe-srv/view/entry/4UY8 PDB 4V47 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V47 PDB 4V48 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V48 PDB 4V4H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4H PDB 4V4Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4Q PDB 4V4V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4V PDB 4V4W http://www.ebi.ac.uk/pdbe-srv/view/entry/4V4W PDB 4V50 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V50 PDB 4V52 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V52 PDB 4V53 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V53 PDB 4V54 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V54 PDB 4V55 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V55 PDB 4V56 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V56 PDB 4V57 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V57 PDB 4V5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5B PDB 4V5H http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5H PDB 4V5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V5Y PDB 4V64 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V64 PDB 4V65 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V65 PDB 4V66 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V66 PDB 4V69 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V69 PDB 4V6C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6C PDB 4V6D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6D PDB 4V6E http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6E PDB 4V6K http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6K PDB 4V6L http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6L PDB 4V6M http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6M PDB 4V6N http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6N PDB 4V6O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6O PDB 4V6P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6P PDB 4V6Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Q PDB 4V6R http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6R PDB 4V6S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6S PDB 4V6T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6T PDB 4V6V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6V PDB 4V6Y http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Y PDB 4V6Z http://www.ebi.ac.uk/pdbe-srv/view/entry/4V6Z PDB 4V70 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V70 PDB 4V71 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V71 PDB 4V72 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V72 PDB 4V73 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V73 PDB 4V74 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V74 PDB 4V75 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V75 PDB 4V76 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V76 PDB 4V77 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V77 PDB 4V78 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V78 PDB 4V79 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V79 PDB 4V7A http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7A PDB 4V7B http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7B PDB 4V7C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7C PDB 4V7D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7D PDB 4V7I http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7I PDB 4V7S http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7S PDB 4V7T http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7T PDB 4V7U http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7U PDB 4V7V http://www.ebi.ac.uk/pdbe-srv/view/entry/4V7V PDB 4V85 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V85 PDB 4V89 http://www.ebi.ac.uk/pdbe-srv/view/entry/4V89 PDB 4V9C http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9C PDB 4V9D http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9D PDB 4V9O http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9O PDB 4V9P http://www.ebi.ac.uk/pdbe-srv/view/entry/4V9P PDB 4WF1 http://www.ebi.ac.uk/pdbe-srv/view/entry/4WF1 PDB 4WOI http://www.ebi.ac.uk/pdbe-srv/view/entry/4WOI PDB 4WWW http://www.ebi.ac.uk/pdbe-srv/view/entry/4WWW PDB 4YBB http://www.ebi.ac.uk/pdbe-srv/view/entry/4YBB PDB 5ADY http://www.ebi.ac.uk/pdbe-srv/view/entry/5ADY PDB 5AFI http://www.ebi.ac.uk/pdbe-srv/view/entry/5AFI PDB 5AKA http://www.ebi.ac.uk/pdbe-srv/view/entry/5AKA PDB 5GAD http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAD PDB 5GAE http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAE PDB 5GAF http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAF PDB 5GAG http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAG PDB 5GAH http://www.ebi.ac.uk/pdbe-srv/view/entry/5GAH PDB 5IQR http://www.ebi.ac.uk/pdbe-srv/view/entry/5IQR PDB 5IT8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5IT8 PDB 5J5B http://www.ebi.ac.uk/pdbe-srv/view/entry/5J5B PDB 5J7L http://www.ebi.ac.uk/pdbe-srv/view/entry/5J7L PDB 5J88 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J88 PDB 5J8A http://www.ebi.ac.uk/pdbe-srv/view/entry/5J8A PDB 5J91 http://www.ebi.ac.uk/pdbe-srv/view/entry/5J91 PDB 5JC9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JC9 PDB 5JTE http://www.ebi.ac.uk/pdbe-srv/view/entry/5JTE PDB 5JU8 http://www.ebi.ac.uk/pdbe-srv/view/entry/5JU8 PDB 5KCR http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCR PDB 5KCS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KCS PDB 5KPS http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPS PDB 5KPV http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPV PDB 5KPW http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPW PDB 5KPX http://www.ebi.ac.uk/pdbe-srv/view/entry/5KPX PDB 5L3P http://www.ebi.ac.uk/pdbe-srv/view/entry/5L3P PDBsum 2J28 http://www.ebi.ac.uk/pdbsum/2J28 PDBsum 2RDO http://www.ebi.ac.uk/pdbsum/2RDO PDBsum 3BBX http://www.ebi.ac.uk/pdbsum/3BBX PDBsum 3J5L http://www.ebi.ac.uk/pdbsum/3J5L PDBsum 3J7Z http://www.ebi.ac.uk/pdbsum/3J7Z PDBsum 3J8G http://www.ebi.ac.uk/pdbsum/3J8G PDBsum 3J9Y http://www.ebi.ac.uk/pdbsum/3J9Y PDBsum 3J9Z http://www.ebi.ac.uk/pdbsum/3J9Z PDBsum 3JA1 http://www.ebi.ac.uk/pdbsum/3JA1 PDBsum 3JBU http://www.ebi.ac.uk/pdbsum/3JBU PDBsum 3JBV http://www.ebi.ac.uk/pdbsum/3JBV PDBsum 3JCD http://www.ebi.ac.uk/pdbsum/3JCD PDBsum 3JCE http://www.ebi.ac.uk/pdbsum/3JCE PDBsum 3JCJ http://www.ebi.ac.uk/pdbsum/3JCJ PDBsum 3JCN http://www.ebi.ac.uk/pdbsum/3JCN PDBsum 4CSU http://www.ebi.ac.uk/pdbsum/4CSU PDBsum 4U1U http://www.ebi.ac.uk/pdbsum/4U1U PDBsum 4U1V http://www.ebi.ac.uk/pdbsum/4U1V PDBsum 4U20 http://www.ebi.ac.uk/pdbsum/4U20 PDBsum 4U24 http://www.ebi.ac.uk/pdbsum/4U24 PDBsum 4U25 http://www.ebi.ac.uk/pdbsum/4U25 PDBsum 4U26 http://www.ebi.ac.uk/pdbsum/4U26 PDBsum 4U27 http://www.ebi.ac.uk/pdbsum/4U27 PDBsum 4UY8 http://www.ebi.ac.uk/pdbsum/4UY8 PDBsum 4V47 http://www.ebi.ac.uk/pdbsum/4V47 PDBsum 4V48 http://www.ebi.ac.uk/pdbsum/4V48 PDBsum 4V4H http://www.ebi.ac.uk/pdbsum/4V4H PDBsum 4V4Q http://www.ebi.ac.uk/pdbsum/4V4Q PDBsum 4V4V http://www.ebi.ac.uk/pdbsum/4V4V PDBsum 4V4W http://www.ebi.ac.uk/pdbsum/4V4W PDBsum 4V50 http://www.ebi.ac.uk/pdbsum/4V50 PDBsum 4V52 http://www.ebi.ac.uk/pdbsum/4V52 PDBsum 4V53 http://www.ebi.ac.uk/pdbsum/4V53 PDBsum 4V54 http://www.ebi.ac.uk/pdbsum/4V54 PDBsum 4V55 http://www.ebi.ac.uk/pdbsum/4V55 PDBsum 4V56 http://www.ebi.ac.uk/pdbsum/4V56 PDBsum 4V57 http://www.ebi.ac.uk/pdbsum/4V57 PDBsum 4V5B http://www.ebi.ac.uk/pdbsum/4V5B PDBsum 4V5H http://www.ebi.ac.uk/pdbsum/4V5H PDBsum 4V5Y http://www.ebi.ac.uk/pdbsum/4V5Y PDBsum 4V64 http://www.ebi.ac.uk/pdbsum/4V64 PDBsum 4V65 http://www.ebi.ac.uk/pdbsum/4V65 PDBsum 4V66 http://www.ebi.ac.uk/pdbsum/4V66 PDBsum 4V69 http://www.ebi.ac.uk/pdbsum/4V69 PDBsum 4V6C http://www.ebi.ac.uk/pdbsum/4V6C PDBsum 4V6D http://www.ebi.ac.uk/pdbsum/4V6D PDBsum 4V6E http://www.ebi.ac.uk/pdbsum/4V6E PDBsum 4V6K http://www.ebi.ac.uk/pdbsum/4V6K PDBsum 4V6L http://www.ebi.ac.uk/pdbsum/4V6L PDBsum 4V6M http://www.ebi.ac.uk/pdbsum/4V6M PDBsum 4V6N http://www.ebi.ac.uk/pdbsum/4V6N PDBsum 4V6O http://www.ebi.ac.uk/pdbsum/4V6O PDBsum 4V6P http://www.ebi.ac.uk/pdbsum/4V6P PDBsum 4V6Q http://www.ebi.ac.uk/pdbsum/4V6Q PDBsum 4V6R http://www.ebi.ac.uk/pdbsum/4V6R PDBsum 4V6S http://www.ebi.ac.uk/pdbsum/4V6S PDBsum 4V6T http://www.ebi.ac.uk/pdbsum/4V6T PDBsum 4V6V http://www.ebi.ac.uk/pdbsum/4V6V PDBsum 4V6Y http://www.ebi.ac.uk/pdbsum/4V6Y PDBsum 4V6Z http://www.ebi.ac.uk/pdbsum/4V6Z PDBsum 4V70 http://www.ebi.ac.uk/pdbsum/4V70 PDBsum 4V71 http://www.ebi.ac.uk/pdbsum/4V71 PDBsum 4V72 http://www.ebi.ac.uk/pdbsum/4V72 PDBsum 4V73 http://www.ebi.ac.uk/pdbsum/4V73 PDBsum 4V74 http://www.ebi.ac.uk/pdbsum/4V74 PDBsum 4V75 http://www.ebi.ac.uk/pdbsum/4V75 PDBsum 4V76 http://www.ebi.ac.uk/pdbsum/4V76 PDBsum 4V77 http://www.ebi.ac.uk/pdbsum/4V77 PDBsum 4V78 http://www.ebi.ac.uk/pdbsum/4V78 PDBsum 4V79 http://www.ebi.ac.uk/pdbsum/4V79 PDBsum 4V7A http://www.ebi.ac.uk/pdbsum/4V7A PDBsum 4V7B http://www.ebi.ac.uk/pdbsum/4V7B PDBsum 4V7C http://www.ebi.ac.uk/pdbsum/4V7C PDBsum 4V7D http://www.ebi.ac.uk/pdbsum/4V7D PDBsum 4V7I http://www.ebi.ac.uk/pdbsum/4V7I PDBsum 4V7S http://www.ebi.ac.uk/pdbsum/4V7S PDBsum 4V7T http://www.ebi.ac.uk/pdbsum/4V7T PDBsum 4V7U http://www.ebi.ac.uk/pdbsum/4V7U PDBsum 4V7V http://www.ebi.ac.uk/pdbsum/4V7V PDBsum 4V85 http://www.ebi.ac.uk/pdbsum/4V85 PDBsum 4V89 http://www.ebi.ac.uk/pdbsum/4V89 PDBsum 4V9C http://www.ebi.ac.uk/pdbsum/4V9C PDBsum 4V9D http://www.ebi.ac.uk/pdbsum/4V9D PDBsum 4V9O http://www.ebi.ac.uk/pdbsum/4V9O PDBsum 4V9P http://www.ebi.ac.uk/pdbsum/4V9P PDBsum 4WF1 http://www.ebi.ac.uk/pdbsum/4WF1 PDBsum 4WOI http://www.ebi.ac.uk/pdbsum/4WOI PDBsum 4WWW http://www.ebi.ac.uk/pdbsum/4WWW PDBsum 4YBB http://www.ebi.ac.uk/pdbsum/4YBB PDBsum 5ADY http://www.ebi.ac.uk/pdbsum/5ADY PDBsum 5AFI http://www.ebi.ac.uk/pdbsum/5AFI PDBsum 5AKA http://www.ebi.ac.uk/pdbsum/5AKA PDBsum 5GAD http://www.ebi.ac.uk/pdbsum/5GAD PDBsum 5GAE http://www.ebi.ac.uk/pdbsum/5GAE PDBsum 5GAF http://www.ebi.ac.uk/pdbsum/5GAF PDBsum 5GAG http://www.ebi.ac.uk/pdbsum/5GAG PDBsum 5GAH http://www.ebi.ac.uk/pdbsum/5GAH PDBsum 5IQR http://www.ebi.ac.uk/pdbsum/5IQR PDBsum 5IT8 http://www.ebi.ac.uk/pdbsum/5IT8 PDBsum 5J5B http://www.ebi.ac.uk/pdbsum/5J5B PDBsum 5J7L http://www.ebi.ac.uk/pdbsum/5J7L PDBsum 5J88 http://www.ebi.ac.uk/pdbsum/5J88 PDBsum 5J8A http://www.ebi.ac.uk/pdbsum/5J8A PDBsum 5J91 http://www.ebi.ac.uk/pdbsum/5J91 PDBsum 5JC9 http://www.ebi.ac.uk/pdbsum/5JC9 PDBsum 5JTE http://www.ebi.ac.uk/pdbsum/5JTE PDBsum 5JU8 http://www.ebi.ac.uk/pdbsum/5JU8 PDBsum 5KCR http://www.ebi.ac.uk/pdbsum/5KCR PDBsum 5KCS http://www.ebi.ac.uk/pdbsum/5KCS PDBsum 5KPS http://www.ebi.ac.uk/pdbsum/5KPS PDBsum 5KPV http://www.ebi.ac.uk/pdbsum/5KPV PDBsum 5KPW http://www.ebi.ac.uk/pdbsum/5KPW PDBsum 5KPX http://www.ebi.ac.uk/pdbsum/5KPX PDBsum 5L3P http://www.ebi.ac.uk/pdbsum/5L3P PRINTS PR00060 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00060 PROSITE PS00586 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00586 PROSITE PS00701 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00701 PSORT swissprot:RL16_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RL16_ECOLI PSORT-B swissprot:RL16_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RL16_ECOLI PSORT2 swissprot:RL16_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RL16_ECOLI Pfam PF00252 http://pfam.xfam.org/family/PF00252 Phobius swissprot:RL16_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RL16_ECOLI PhylomeDB P0ADY7 http://phylomedb.org/?seqid=P0ADY7 ProteinModelPortal P0ADY7 http://www.proteinmodelportal.org/query/uniprot/P0ADY7 PubMed 10094780 http://www.ncbi.nlm.nih.gov/pubmed/10094780 PubMed 12809609 http://www.ncbi.nlm.nih.gov/pubmed/12809609 PubMed 16272117 http://www.ncbi.nlm.nih.gov/pubmed/16272117 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 23103944 http://www.ncbi.nlm.nih.gov/pubmed/23103944 PubMed 24844575 http://www.ncbi.nlm.nih.gov/pubmed/24844575 PubMed 25310980 http://www.ncbi.nlm.nih.gov/pubmed/25310980 PubMed 3298242 http://www.ncbi.nlm.nih.gov/pubmed/3298242 PubMed 3892488 http://www.ncbi.nlm.nih.gov/pubmed/3892488 PubMed 6154696 http://www.ncbi.nlm.nih.gov/pubmed/6154696 PubMed 786730 http://www.ncbi.nlm.nih.gov/pubmed/786730 PubMed 8524654 http://www.ncbi.nlm.nih.gov/pubmed/8524654 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417772 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417772 RefSeq WP_000941212 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000941212 SMR P0ADY7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADY7 STRING 511145.b3313 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3313&targetmode=cogs STRING COG0197 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0197&targetmode=cogs SUPFAM SSF54686 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54686 TIGRFAMs TIGR01164 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01164 UniProtKB RL16_ECOLI http://www.uniprot.org/uniprot/RL16_ECOLI UniProtKB-AC P0ADY7 http://www.uniprot.org/uniprot/P0ADY7 charge swissprot:RL16_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RL16_ECOLI eggNOG COG0197 http://eggnogapi.embl.de/nog_data/html/tree/COG0197 eggNOG ENOG4108R70 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108R70 epestfind swissprot:RL16_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RL16_ECOLI garnier swissprot:RL16_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RL16_ECOLI helixturnhelix swissprot:RL16_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RL16_ECOLI hmoment swissprot:RL16_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RL16_ECOLI iep swissprot:RL16_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RL16_ECOLI inforesidue swissprot:RL16_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RL16_ECOLI octanol swissprot:RL16_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RL16_ECOLI pepcoil swissprot:RL16_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RL16_ECOLI pepdigest swissprot:RL16_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RL16_ECOLI pepinfo swissprot:RL16_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RL16_ECOLI pepnet swissprot:RL16_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RL16_ECOLI pepstats swissprot:RL16_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RL16_ECOLI pepwheel swissprot:RL16_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RL16_ECOLI pepwindow swissprot:RL16_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RL16_ECOLI sigcleave swissprot:RL16_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RL16_ECOLI ## Database ID URL or Descriptions # BRENDA 4.1.1.15 2026 # CATALYTIC ACTIVITY DCEB_ECOLI L-glutamate = 4-aminobutanoate + CO(2). # COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI 597326; # EcoGene EG11490 gadB # FUNCTION DCEB_ECOLI Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0004351 glutamate decarboxylase activity; IDA:EcoCyc. # GO_function GO:0030170 pyridoxal phosphate binding; IEA:InterPro. # GO_process GO:0006536 glutamate metabolic process; IEA:InterPro. # GO_process GO:0051454 intracellular pH elevation; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0042592 homeostatic process # Gene3D 3.40.640.10 -; 1. # INDUCTION DCEB_ECOLI By acidic conditions. Expression is regulated by a complex system involving RpoS, cAMP, CRP, EvgAS, H-NS, GadE, GadW and GadX. The level of involvement for each regulator varies depending upon the growth phase and the medium. {ECO 0000269|PubMed 10383761, ECO 0000269|PubMed 11976288, ECO 0000269|PubMed 12399493, ECO 0000269|PubMed 12446650, ECO 0000269|PubMed 12694615, ECO 0000269|PubMed 12867478, ECO 0000269|PubMed 12940989}. # IntAct P69910 13 # InterPro IPR002129 PyrdxlP-dep_de-COase # InterPro IPR010107 Glutamate_decarboxylase # InterPro IPR015421 PyrdxlP-dep_Trfase_major_sub1 # InterPro IPR015424 PyrdxlP-dep_Trfase # InterPro IPR021115 Pyridoxal-P_BS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00250 Alanine, aspartate and glutamate metabolism # KEGG_Pathway ko00410 beta-Alanine metabolism # KEGG_Pathway ko00430 Taurine and hypotaurine metabolism # KEGG_Pathway ko00650 Butanoate metabolism # KEGG_Pathway ko04727 GABAergic synapse # KEGG_Pathway ko04940 Type I diabetes mellitus # MISCELLANEOUS DCEB_ECOLI Changing Lys-276 to Ala increases thermal stability and protease resistance. The unfolding temperature is increased by 11 degrees Celsius. # Organism DCEB_ECOLI Escherichia coli (strain K12) # PATRIC 32118280 VBIEscCol129921_1560 # PDB 1PMM X-ray; 2.00 A; A/B/C/D/E/F=1-466 # PDB 1PMO X-ray; 2.30 A; A/B/C/D/E/F=1-466 # PDB 2DGK X-ray; 1.90 A; A/B/C/D/E/F=15-466 # PDB 2DGL X-ray; 3.15 A; A/B/C/D/E/F=1-466 # PDB 2DGM X-ray; 1.95 A; A/B/C/D/E/F=1-466 # PDB 3FZ6 X-ray; 2.82 A; A/B/C/D/E/F=1-466 # PDB 3FZ7 X-ray; 2.50 A; A/B/C/D/E/F=1-466 # PDB 3FZ8 X-ray; 3.00 A; A/B/C/D/E/F=1-466 # PIR B43332 B43332 # PROSITE PS00392 DDC_GAD_HDC_YDC # Pfam PF00282 Pyridoxal_deC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DCEB_ECOLI Glutamate decarboxylase beta # RefSeq NP_416010 NC_000913.3 # RefSeq WP_000358930 NZ_LN832404.1 # SIMILARITY Belongs to the group II decarboxylase family. {ECO 0000305}. # SUBCELLULAR LOCATION DCEB_ECOLI Cytoplasm {ECO 0000269|PubMed 12912902}. Membrane {ECO 0000269|PubMed 12912902}. Note=Localized exclusively in the cytoplasm at neutral pH, but is recruited to the membrane when the pH falls. # SUBUNIT Homohexamer composed of three dimers. {ECO:0000269|PubMed 12912902}. # SUPFAM SSF53383 SSF53383 # TIGRFAMs TIGR01788 Glu-decarb-GAD # eggNOG COG0076 LUCA # eggNOG ENOG4105CVK Bacteria BLAST swissprot:DCEB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DCEB_ECOLI BioCyc ECOL316407:JW1488-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1488-MONOMER BioCyc EcoCyc:GLUTDECARBOXB-MONOMER http://biocyc.org/getid?id=EcoCyc:GLUTDECARBOXB-MONOMER BioCyc MetaCyc:GLUTDECARBOXB-MONOMER http://biocyc.org/getid?id=MetaCyc:GLUTDECARBOXB-MONOMER COG COG0076 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0076 DIP DIP-36202N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36202N DOI 10.1007/BF00282791 http://dx.doi.org/10.1007/BF00282791 DOI 10.1016/S0300-9084(97)84334-9 http://dx.doi.org/10.1016/S0300-9084(97)84334-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1999.01430.x http://dx.doi.org/10.1046/j.1365-2958.1999.01430.x DOI 10.1046/j.1365-2958.2003.03477.x http://dx.doi.org/10.1046/j.1365-2958.2003.03477.x DOI 10.1046/j.1365-2958.2003.03633.x http://dx.doi.org/10.1046/j.1365-2958.2003.03633.x DOI 10.1046/j.1432-1033.2002.03149.x http://dx.doi.org/10.1046/j.1432-1033.2002.03149.x DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/emboj/cdg403 http://dx.doi.org/10.1093/emboj/cdg403 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.184.10.2603-2613.2002 http://dx.doi.org/10.1128/JB.184.10.2603-2613.2002 DOI 10.1128/JB.184.22.6225-6234.2002 http://dx.doi.org/10.1128/JB.184.22.6225-6234.2002 DOI 10.1128/JB.184.24.7001-7012.2002 http://dx.doi.org/10.1128/JB.184.24.7001-7012.2002 DOI 10.1128/JB.185.15.4644-4647.2003 http://dx.doi.org/10.1128/JB.185.15.4644-4647.2003 EC_number EC:4.1.1.15 http://www.genome.jp/dbget-bin/www_bget?EC:4.1.1.15 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M84025 http://www.ebi.ac.uk/ena/data/view/M84025 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X71917 http://www.ebi.ac.uk/ena/data/view/X71917 ENZYME 4.1.1.15 http://enzyme.expasy.org/EC/4.1.1.15 EchoBASE EB1453 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1453 EcoGene EG11490 http://www.ecogene.org/geneInfo.php?eg_id=EG11490 EnsemblBacteria AAC74566 http://www.ensemblgenomes.org/id/AAC74566 EnsemblBacteria AAC74566 http://www.ensemblgenomes.org/id/AAC74566 EnsemblBacteria BAA15163 http://www.ensemblgenomes.org/id/BAA15163 EnsemblBacteria BAA15163 http://www.ensemblgenomes.org/id/BAA15163 EnsemblBacteria BAA15163 http://www.ensemblgenomes.org/id/BAA15163 EnsemblBacteria b1493 http://www.ensemblgenomes.org/id/b1493 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0004351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004351 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_process GO:0006536 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006536 GO_process GO:0051454 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051454 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 Gene3D 3.40.640.10 http://www.cathdb.info/version/latest/superfamily/3.40.640.10 GeneID 946058 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946058 HOGENOM HOG000070228 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000070228&db=HOGENOM6 InParanoid P69910 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P69910 IntAct P69910 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69910* IntEnz 4.1.1.15 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=4.1.1.15 InterPro IPR002129 http://www.ebi.ac.uk/interpro/entry/IPR002129 InterPro IPR010107 http://www.ebi.ac.uk/interpro/entry/IPR010107 InterPro IPR015421 http://www.ebi.ac.uk/interpro/entry/IPR015421 InterPro IPR015424 http://www.ebi.ac.uk/interpro/entry/IPR015424 InterPro IPR021115 http://www.ebi.ac.uk/interpro/entry/IPR021115 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1488 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1488 KEGG_Gene eco:b1493 http://www.genome.jp/dbget-bin/www_bget?eco:b1493 KEGG_Orthology KO:K01580 http://www.genome.jp/dbget-bin/www_bget?KO:K01580 KEGG_Pathway ko00250 http://www.genome.jp/kegg-bin/show_pathway?ko00250 KEGG_Pathway ko00410 http://www.genome.jp/kegg-bin/show_pathway?ko00410 KEGG_Pathway ko00430 http://www.genome.jp/kegg-bin/show_pathway?ko00430 KEGG_Pathway ko00650 http://www.genome.jp/kegg-bin/show_pathway?ko00650 KEGG_Pathway ko04727 http://www.genome.jp/kegg-bin/show_pathway?ko04727 KEGG_Pathway ko04940 http://www.genome.jp/kegg-bin/show_pathway?ko04940 KEGG_Reaction rn:R00261 http://www.genome.jp/dbget-bin/www_bget?rn:R00261 KEGG_Reaction rn:R00489 http://www.genome.jp/dbget-bin/www_bget?rn:R00489 KEGG_Reaction rn:R01682 http://www.genome.jp/dbget-bin/www_bget?rn:R01682 KEGG_Reaction rn:R02466 http://www.genome.jp/dbget-bin/www_bget?rn:R02466 MINT MINT-1256225 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1256225 OMA FEVEPRY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FEVEPRY PDB 1PMM http://www.ebi.ac.uk/pdbe-srv/view/entry/1PMM PDB 1PMO http://www.ebi.ac.uk/pdbe-srv/view/entry/1PMO PDB 2DGK http://www.ebi.ac.uk/pdbe-srv/view/entry/2DGK PDB 2DGL http://www.ebi.ac.uk/pdbe-srv/view/entry/2DGL PDB 2DGM http://www.ebi.ac.uk/pdbe-srv/view/entry/2DGM PDB 3FZ6 http://www.ebi.ac.uk/pdbe-srv/view/entry/3FZ6 PDB 3FZ7 http://www.ebi.ac.uk/pdbe-srv/view/entry/3FZ7 PDB 3FZ8 http://www.ebi.ac.uk/pdbe-srv/view/entry/3FZ8 PDBsum 1PMM http://www.ebi.ac.uk/pdbsum/1PMM PDBsum 1PMO http://www.ebi.ac.uk/pdbsum/1PMO PDBsum 2DGK http://www.ebi.ac.uk/pdbsum/2DGK PDBsum 2DGL http://www.ebi.ac.uk/pdbsum/2DGL PDBsum 2DGM http://www.ebi.ac.uk/pdbsum/2DGM PDBsum 3FZ6 http://www.ebi.ac.uk/pdbsum/3FZ6 PDBsum 3FZ7 http://www.ebi.ac.uk/pdbsum/3FZ7 PDBsum 3FZ8 http://www.ebi.ac.uk/pdbsum/3FZ8 PROSITE PS00392 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00392 PSORT swissprot:DCEB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DCEB_ECOLI PSORT-B swissprot:DCEB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DCEB_ECOLI PSORT2 swissprot:DCEB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DCEB_ECOLI Pfam PF00282 http://pfam.xfam.org/family/PF00282 Phobius swissprot:DCEB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DCEB_ECOLI PhylomeDB P69910 http://phylomedb.org/?seqid=P69910 ProteinModelPortal P69910 http://www.proteinmodelportal.org/query/uniprot/P69910 PubMed 10383761 http://www.ncbi.nlm.nih.gov/pubmed/10383761 PubMed 11976288 http://www.ncbi.nlm.nih.gov/pubmed/11976288 PubMed 12383249 http://www.ncbi.nlm.nih.gov/pubmed/12383249 PubMed 12399493 http://www.ncbi.nlm.nih.gov/pubmed/12399493 PubMed 12446650 http://www.ncbi.nlm.nih.gov/pubmed/12446650 PubMed 12694615 http://www.ncbi.nlm.nih.gov/pubmed/12694615 PubMed 12867478 http://www.ncbi.nlm.nih.gov/pubmed/12867478 PubMed 12912902 http://www.ncbi.nlm.nih.gov/pubmed/12912902 PubMed 12940989 http://www.ncbi.nlm.nih.gov/pubmed/12940989 PubMed 1522060 http://www.ncbi.nlm.nih.gov/pubmed/1522060 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 8455549 http://www.ncbi.nlm.nih.gov/pubmed/8455549 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9116051 http://www.ncbi.nlm.nih.gov/pubmed/9116051 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416010 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416010 RefSeq WP_000358930 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000358930 SMR P69910 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69910 STRING 511145.b1493 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1493&targetmode=cogs STRING COG0076 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0076&targetmode=cogs SUPFAM SSF53383 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53383 TIGRFAMs TIGR01788 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01788 UniProtKB DCEB_ECOLI http://www.uniprot.org/uniprot/DCEB_ECOLI UniProtKB-AC P69910 http://www.uniprot.org/uniprot/P69910 charge swissprot:DCEB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DCEB_ECOLI eggNOG COG0076 http://eggnogapi.embl.de/nog_data/html/tree/COG0076 eggNOG ENOG4105CVK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CVK epestfind swissprot:DCEB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DCEB_ECOLI garnier swissprot:DCEB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DCEB_ECOLI helixturnhelix swissprot:DCEB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DCEB_ECOLI hmoment swissprot:DCEB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DCEB_ECOLI iep swissprot:DCEB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DCEB_ECOLI inforesidue swissprot:DCEB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DCEB_ECOLI octanol swissprot:DCEB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DCEB_ECOLI pepcoil swissprot:DCEB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DCEB_ECOLI pepdigest swissprot:DCEB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DCEB_ECOLI pepinfo swissprot:DCEB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DCEB_ECOLI pepnet swissprot:DCEB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DCEB_ECOLI pepstats swissprot:DCEB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DCEB_ECOLI pepwheel swissprot:DCEB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DCEB_ECOLI pepwindow swissprot:DCEB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DCEB_ECOLI sigcleave swissprot:DCEB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DCEB_ECOLI ## Database ID URL or Descriptions # FUNCTION TRAQ_ECOLI Required for efficient expression of pilin. Functions as a transient chaperone for propilin, preventing it from being prematurely degraded, and also promotes propilin translocation, positioning it in the membrane for processing to mature pilin. {ECO 0000269|PubMed 8730869}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0000746 conjugation; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0008150 biological_process # InterPro IPR014112 TraQ # Organism TRAQ_ECOLI Escherichia coli (strain K12) # PIR D32238 BVECAQ # PIRSF PIRSF003265 TraQ # Pfam PF09679 TraQ # RecName TRAQ_ECOLI Protein TraQ # RefSeq NP_061473 NC_002483.1 # RefSeq NP_862939 NC_004998.1 # RefSeq WP_000624109 NZ_CP014273.1 # RefSeq YP_006953815 NC_019089.1 # RefSeq YP_008826456 NC_022885.1 # RefSeq YP_009066498 NC_025106.1 # RefSeq YP_009068330 NC_025139.1 # RefSeq YP_009070595 NC_025175.1 # RefSeq YP_009071251 NC_025179.1 # SUBCELLULAR LOCATION TRAQ_ECOLI Cell inner membrane {ECO 0000305}; Multi- pass membrane protein {ECO 0000305}. # SUBUNIT TRAQ_ECOLI Interacts with pilin. {ECO 0000269|PubMed 10564517, ECO 0000269|PubMed 8095257}. # TIGRFAMs TIGR02741 TraQ BLAST swissprot:TRAQ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRAQ_ECOLI DIP DIP-27655N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-27655N DOI 10.1046/j.1365-2958.1999.01640.x http://dx.doi.org/10.1046/j.1365-2958.1999.01640.x DOI 10.1111/j.1365-2958.1996.tb02472.x http://dx.doi.org/10.1111/j.1365-2958.1996.tb02472.x EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 EMBL M20787 http://www.ebi.ac.uk/ena/data/view/M20787 EMBL U01159 http://www.ebi.ac.uk/ena/data/view/U01159 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0000746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000746 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 1263562 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263562 GeneID 13906760 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13906760 GeneID 1446503 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1446503 GeneID 17688612 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=17688612 GeneID 20471986 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20471986 GeneID 20491460 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20491460 GeneID 20492663 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20492663 GeneID 20493323 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20493323 IntAct P18033 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P18033* InterPro IPR014112 http://www.ebi.ac.uk/interpro/entry/IPR014112 OMA QQAMMAE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QQAMMAE PSORT swissprot:TRAQ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRAQ_ECOLI PSORT-B swissprot:TRAQ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRAQ_ECOLI PSORT2 swissprot:TRAQ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRAQ_ECOLI Pfam PF09679 http://pfam.xfam.org/family/PF09679 Phobius swissprot:TRAQ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRAQ_ECOLI ProteinModelPortal P18033 http://www.proteinmodelportal.org/query/uniprot/P18033 PubMed 10564517 http://www.ncbi.nlm.nih.gov/pubmed/10564517 PubMed 2536655 http://www.ncbi.nlm.nih.gov/pubmed/2536655 PubMed 7915817 http://www.ncbi.nlm.nih.gov/pubmed/7915817 PubMed 8095257 http://www.ncbi.nlm.nih.gov/pubmed/8095257 PubMed 8730869 http://www.ncbi.nlm.nih.gov/pubmed/8730869 RefSeq NP_061473 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061473 RefSeq NP_862939 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_862939 RefSeq WP_000624109 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000624109 RefSeq YP_006953815 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_006953815 RefSeq YP_008826456 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_008826456 RefSeq YP_009066498 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009066498 RefSeq YP_009068330 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009068330 RefSeq YP_009070595 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009070595 RefSeq YP_009071251 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_009071251 SMR P18033 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P18033 TIGRFAMs TIGR02741 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02741 UniProtKB TRAQ_ECOLI http://www.uniprot.org/uniprot/TRAQ_ECOLI UniProtKB-AC P18033 http://www.uniprot.org/uniprot/P18033 charge swissprot:TRAQ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRAQ_ECOLI epestfind swissprot:TRAQ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRAQ_ECOLI garnier swissprot:TRAQ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRAQ_ECOLI helixturnhelix swissprot:TRAQ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRAQ_ECOLI hmoment swissprot:TRAQ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRAQ_ECOLI iep swissprot:TRAQ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRAQ_ECOLI inforesidue swissprot:TRAQ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRAQ_ECOLI octanol swissprot:TRAQ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRAQ_ECOLI pepcoil swissprot:TRAQ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRAQ_ECOLI pepdigest swissprot:TRAQ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRAQ_ECOLI pepinfo swissprot:TRAQ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRAQ_ECOLI pepnet swissprot:TRAQ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRAQ_ECOLI pepstats swissprot:TRAQ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRAQ_ECOLI pepwheel swissprot:TRAQ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRAQ_ECOLI pepwindow swissprot:TRAQ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRAQ_ECOLI sigcleave swissprot:TRAQ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRAQ_ECOLI ## Database ID URL or Descriptions # BioGrid 4260943 192 # COFACTOR YCFH_ECOLI Name=Co(2+); Xref=ChEBI CHEBI 48828; Evidence={ECO 0000269|PubMed 19332551}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000269|PubMed 19332551}; Name=Ni(2+); Xref=ChEBI CHEBI 49786; Evidence={ECO 0000269|PubMed 19332551}; Note=Binds 2 divalent metal cations per subunit. {ECO 0000269|Ref.7}; # EcoGene EG12303 ycfH # FUNCTION YCFH_ECOLI Has D-tyrosyl-tRNA deacylase activity in vitro. {ECO 0000269|PubMed 19332551}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0004536 deoxyribonuclease activity; IBA:GO_Central. # GO_function GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0006308 DNA catabolic process; IBA:GO_Central. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0004518 nuclease activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0034655 nucleobase-containing compound catabolic process # IntAct P0AFQ7 8 # InterPro IPR001130 TatD_family # InterPro IPR015991 Hydrolase_TatD-type # InterPro IPR018228 DNase_TatD-rel_CS # InterPro IPR032466 Metal_Hydrolase # KEGG_Brite ko01000 Enzymes # Organism YCFH_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10060 PTHR10060 # PATRIC 32117441 VBIEscCol129921_1143 # PDB 1YIX X-ray; 1.90 A; A/B=1-265 # PIR A64854 A64854 # PIRSF PIRSF005902 DNase_TatD # PROSITE PS01091 TATD_3 # PROSITE PS01137 TATD_1 # Pfam PF01026 TatD_DNase # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Uncharacterized metal-dependent hydrolase YcfH {ECO 0000305} # RefSeq NP_415618 NC_000913.3 # RefSeq WP_000480245 NZ_LN832404.1 # SIMILARITY Belongs to the TatD-type hydrolase family. {ECO 0000305}. # SUPFAM SSF51556 SSF51556 # TIGRFAMs TIGR00010 TIGR00010 # eggNOG COG0084 LUCA # eggNOG ENOG4105F8V Bacteria BLAST swissprot:YCFH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YCFH_ECOLI BioCyc ECOL316407:JW1086-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1086-MONOMER BioCyc EcoCyc:EG12303-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12303-MONOMER COG COG0084 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0084 DIP DIP-48157N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48157N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M808173200 http://dx.doi.org/10.1074/jbc.M808173200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.-.- {ECO:0000305} http://www.genome.jp/dbget-bin/www_bget?EC:3.1.-.- {ECO:0000305} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L01483 http://www.ebi.ac.uk/ena/data/view/L01483 EMBL L04577 http://www.ebi.ac.uk/ena/data/view/L04577 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 3.1.-.- {ECO:0000305} http://enzyme.expasy.org/EC/3.1.-.- {ECO:0000305} EchoBASE EB2209 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2209 EcoGene EG12303 http://www.ecogene.org/geneInfo.php?eg_id=EG12303 EnsemblBacteria AAC74184 http://www.ensemblgenomes.org/id/AAC74184 EnsemblBacteria AAC74184 http://www.ensemblgenomes.org/id/AAC74184 EnsemblBacteria BAA35907 http://www.ensemblgenomes.org/id/BAA35907 EnsemblBacteria BAA35907 http://www.ensemblgenomes.org/id/BAA35907 EnsemblBacteria BAA35907 http://www.ensemblgenomes.org/id/BAA35907 EnsemblBacteria b1100 http://www.ensemblgenomes.org/id/b1100 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0004536 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004536 GO_function GO:0016888 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016888 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0006308 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006308 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0034655 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034655 GeneID 945656 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945656 HOGENOM HOG000201520 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000201520&db=HOGENOM6 InParanoid P0AFQ7 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AFQ7 IntAct P0AFQ7 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AFQ7* IntEnz 3.1.-.- {ECO:0000305} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.-.- {ECO:0000305} InterPro IPR001130 http://www.ebi.ac.uk/interpro/entry/IPR001130 InterPro IPR015991 http://www.ebi.ac.uk/interpro/entry/IPR015991 InterPro IPR018228 http://www.ebi.ac.uk/interpro/entry/IPR018228 InterPro IPR032466 http://www.ebi.ac.uk/interpro/entry/IPR032466 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1086 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1086 KEGG_Gene eco:b1100 http://www.genome.jp/dbget-bin/www_bget?eco:b1100 KEGG_Orthology KO:K03424 http://www.genome.jp/dbget-bin/www_bget?KO:K03424 MINT MINT-1267935 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1267935 OMA FVDHIKV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FVDHIKV PANTHER PTHR10060 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10060 PDB 1YIX http://www.ebi.ac.uk/pdbe-srv/view/entry/1YIX PDBsum 1YIX http://www.ebi.ac.uk/pdbsum/1YIX PROSITE PS01091 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01091 PROSITE PS01137 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01137 PSORT swissprot:YCFH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YCFH_ECOLI PSORT-B swissprot:YCFH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YCFH_ECOLI PSORT2 swissprot:YCFH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YCFH_ECOLI Pfam PF01026 http://pfam.xfam.org/family/PF01026 Phobius swissprot:YCFH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YCFH_ECOLI PhylomeDB P0AFQ7 http://phylomedb.org/?seqid=P0AFQ7 ProteinModelPortal P0AFQ7 http://www.proteinmodelportal.org/query/uniprot/P0AFQ7 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19332551 http://www.ncbi.nlm.nih.gov/pubmed/19332551 PubMed 8505303 http://www.ncbi.nlm.nih.gov/pubmed/8505303 PubMed 8509334 http://www.ncbi.nlm.nih.gov/pubmed/8509334 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415618 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415618 RefSeq WP_000480245 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000480245 SMR P0AFQ7 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AFQ7 STRING 511145.b1100 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1100&targetmode=cogs STRING COG0084 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0084&targetmode=cogs SUPFAM SSF51556 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51556 TIGRFAMs TIGR00010 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00010 UniProtKB YCFH_ECOLI http://www.uniprot.org/uniprot/YCFH_ECOLI UniProtKB-AC P0AFQ7 http://www.uniprot.org/uniprot/P0AFQ7 charge swissprot:YCFH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YCFH_ECOLI eggNOG COG0084 http://eggnogapi.embl.de/nog_data/html/tree/COG0084 eggNOG ENOG4105F8V http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F8V epestfind swissprot:YCFH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YCFH_ECOLI garnier swissprot:YCFH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YCFH_ECOLI helixturnhelix swissprot:YCFH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YCFH_ECOLI hmoment swissprot:YCFH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YCFH_ECOLI iep swissprot:YCFH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YCFH_ECOLI inforesidue swissprot:YCFH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YCFH_ECOLI octanol swissprot:YCFH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YCFH_ECOLI pepcoil swissprot:YCFH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YCFH_ECOLI pepdigest swissprot:YCFH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YCFH_ECOLI pepinfo swissprot:YCFH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YCFH_ECOLI pepnet swissprot:YCFH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YCFH_ECOLI pepstats swissprot:YCFH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YCFH_ECOLI pepwheel swissprot:YCFH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YCFH_ECOLI pepwindow swissprot:YCFH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YCFH_ECOLI sigcleave swissprot:YCFH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YCFH_ECOLI ## Database ID URL or Descriptions # AltName PTPD_ECOLI EIID-Aga # AltName PTPD_ECOLI PTS system N-acetylgalactosamine-specific EIID component # BioGrid 4261993 7 # DOMAIN PTPD_ECOLI The EIID domain, with its homologous EIIC domain, forms the PTS system translocation channel and contains part of its specific substrate-binding site. # EcoGene EG12771 agaD # FUNCTION PTPD_ECOLI The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in N-acetylgalactosamine transport. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006810 transport # IntAct P42911 2 # InterPro IPR004704 PTS_IID_man # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00287 PTS system, galactosamine-specific II component # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko00052 Galactose metabolism # KEGG_Pathway ko02060 Phosphotransferase system (PTS) # Organism PTPD_ECOLI Escherichia coli (strain K12) # PATRIC 32121698 VBIEscCol129921_3235 # PIR H65103 H65103 # PROSITE PS51108 PTS_EIID # Pfam PF03613 EIID-AGA # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PTPD_ECOLI N-acetylgalactosamine permease IID component # RefSeq NP_417609 NC_000913.3 # RefSeq WP_000534347 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA57943.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Contains 1 PTS EIID domain. {ECO:0000255|PROSITE- ProRule PRU00431}. # SUBCELLULAR LOCATION PTPD_ECOLI Cell inner membrane {ECO 0000255|PROSITE- ProRule PRU00431, ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255|PROSITE-ProRule PRU00431, ECO 0000269|PubMed 15919996}. # TCDB 4.A.6.1 the pts mannose-fructose-sorbose (man) family # TIGRFAMs TIGR00828 EIID-AGA # eggNOG COG3716 LUCA # eggNOG ENOG4105F3R Bacteria BLAST swissprot:PTPD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTPD_ECOLI BioCyc ECOL316407:JW3109-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3109-MONOMER BioCyc EcoCyc:AGAD-MONOMER http://biocyc.org/getid?id=EcoCyc:AGAD-MONOMER COG COG3716 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3716 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.2000.01969.x http://dx.doi.org/10.1046/j.1365-2958.2000.01969.x DOI 10.1099/13500872-142-2-231 http://dx.doi.org/10.1099/13500872-142-2-231 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AF228498 http://www.ebi.ac.uk/ena/data/view/AF228498 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2624 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2624 EcoGene EG12771 http://www.ecogene.org/geneInfo.php?eg_id=EG12771 EnsemblBacteria AAC76174 http://www.ensemblgenomes.org/id/AAC76174 EnsemblBacteria AAC76174 http://www.ensemblgenomes.org/id/AAC76174 EnsemblBacteria BAE77186 http://www.ensemblgenomes.org/id/BAE77186 EnsemblBacteria BAE77186 http://www.ensemblgenomes.org/id/BAE77186 EnsemblBacteria BAE77186 http://www.ensemblgenomes.org/id/BAE77186 EnsemblBacteria b3140 http://www.ensemblgenomes.org/id/b3140 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 947649 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947649 HOGENOM HOG000098669 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000098669&db=HOGENOM6 IntAct P42911 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P42911* InterPro IPR004704 http://www.ebi.ac.uk/interpro/entry/IPR004704 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3109 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3109 KEGG_Gene eco:b3140 http://www.genome.jp/dbget-bin/www_bget?eco:b3140 KEGG_Orthology KO:K10986 http://www.genome.jp/dbget-bin/www_bget?KO:K10986 KEGG_Pathway ko00052 http://www.genome.jp/kegg-bin/show_pathway?ko00052 KEGG_Pathway ko02060 http://www.genome.jp/kegg-bin/show_pathway?ko02060 KEGG_Reaction rn:R08367 http://www.genome.jp/dbget-bin/www_bget?rn:R08367 OMA TTWLMRI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TTWLMRI PROSITE PS51108 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51108 PSORT swissprot:PTPD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTPD_ECOLI PSORT-B swissprot:PTPD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTPD_ECOLI PSORT2 swissprot:PTPD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTPD_ECOLI Pfam PF03613 http://pfam.xfam.org/family/PF03613 Phobius swissprot:PTPD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTPD_ECOLI PhylomeDB P42911 http://phylomedb.org/?seqid=P42911 ProteinModelPortal P42911 http://www.proteinmodelportal.org/query/uniprot/P42911 PubMed 10931310 http://www.ncbi.nlm.nih.gov/pubmed/10931310 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8932697 http://www.ncbi.nlm.nih.gov/pubmed/8932697 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417609 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417609 RefSeq WP_000534347 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000534347 STRING 511145.b3140 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3140&targetmode=cogs STRING COG3716 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3716&targetmode=cogs TCDB 4.A.6.1 http://www.tcdb.org/search/result.php?tc=4.A.6.1 TIGRFAMs TIGR00828 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00828 UniProtKB PTPD_ECOLI http://www.uniprot.org/uniprot/PTPD_ECOLI UniProtKB-AC P42911 http://www.uniprot.org/uniprot/P42911 charge swissprot:PTPD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTPD_ECOLI eggNOG COG3716 http://eggnogapi.embl.de/nog_data/html/tree/COG3716 eggNOG ENOG4105F3R http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F3R epestfind swissprot:PTPD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTPD_ECOLI garnier swissprot:PTPD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTPD_ECOLI helixturnhelix swissprot:PTPD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTPD_ECOLI hmoment swissprot:PTPD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTPD_ECOLI iep swissprot:PTPD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTPD_ECOLI inforesidue swissprot:PTPD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTPD_ECOLI octanol swissprot:PTPD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTPD_ECOLI pepcoil swissprot:PTPD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTPD_ECOLI pepdigest swissprot:PTPD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTPD_ECOLI pepinfo swissprot:PTPD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTPD_ECOLI pepnet swissprot:PTPD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTPD_ECOLI pepstats swissprot:PTPD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTPD_ECOLI pepwheel swissprot:PTPD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTPD_ECOLI pepwindow swissprot:PTPD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTPD_ECOLI sigcleave swissprot:PTPD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTPD_ECOLI ## Database ID URL or Descriptions # BioGrid 4261037 7 # EcoGene EG13242 yecJ # IntAct P0AD10 11 # InterPro IPR020262 Uncharacterised_YecJ # Organism YECJ_ECOLI Escherichia coli (strain K12) # PATRIC 32119131 VBIEscCol129921_1983 # PIR G64953 G64953 # Pfam PF10964 DUF2766 # ProDom PD060536 Uncharacterised_YecJ # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YECJ_ECOLI Uncharacterized protein YecJ # RefSeq NP_416416 NC_000913.3 # RefSeq WP_000082127 NZ_LN832404.1 # eggNOG ENOG4105N4N Bacteria # eggNOG ENOG4111W6F LUCA BLAST swissprot:YECJ_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YECJ_ECOLI BioCyc ECOL316407:JW1891-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1891-MONOMER BioCyc EcoCyc:MONOMER0-2677 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2677 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U39484 http://www.ebi.ac.uk/ena/data/view/U39484 EchoBASE EB3031 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3031 EcoGene EG13242 http://www.ecogene.org/geneInfo.php?eg_id=EG13242 EnsemblBacteria AAC74973 http://www.ensemblgenomes.org/id/AAC74973 EnsemblBacteria AAC74973 http://www.ensemblgenomes.org/id/AAC74973 EnsemblBacteria BAA15727 http://www.ensemblgenomes.org/id/BAA15727 EnsemblBacteria BAA15727 http://www.ensemblgenomes.org/id/BAA15727 EnsemblBacteria BAA15727 http://www.ensemblgenomes.org/id/BAA15727 EnsemblBacteria b4537 http://www.ensemblgenomes.org/id/b4537 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 946388 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946388 HOGENOM HOG000219303 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000219303&db=HOGENOM6 IntAct P0AD10 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AD10* InterPro IPR020262 http://www.ebi.ac.uk/interpro/entry/IPR020262 KEGG_Gene ecj:JW1891 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1891 KEGG_Gene eco:b4537 http://www.genome.jp/dbget-bin/www_bget?eco:b4537 OMA RDKMASQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RDKMASQ PSORT swissprot:YECJ_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YECJ_ECOLI PSORT-B swissprot:YECJ_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YECJ_ECOLI PSORT2 swissprot:YECJ_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YECJ_ECOLI Pfam PF10964 http://pfam.xfam.org/family/PF10964 Phobius swissprot:YECJ_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YECJ_ECOLI ProteinModelPortal P0AD10 http://www.proteinmodelportal.org/query/uniprot/P0AD10 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416416 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416416 RefSeq WP_000082127 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000082127 STRING 511145.b4537 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4537&targetmode=cogs UniProtKB YECJ_ECOLI http://www.uniprot.org/uniprot/YECJ_ECOLI UniProtKB-AC P0AD10 http://www.uniprot.org/uniprot/P0AD10 charge swissprot:YECJ_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YECJ_ECOLI eggNOG ENOG4105N4N http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105N4N eggNOG ENOG4111W6F http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111W6F epestfind swissprot:YECJ_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YECJ_ECOLI garnier swissprot:YECJ_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YECJ_ECOLI helixturnhelix swissprot:YECJ_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YECJ_ECOLI hmoment swissprot:YECJ_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YECJ_ECOLI iep swissprot:YECJ_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YECJ_ECOLI inforesidue swissprot:YECJ_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YECJ_ECOLI octanol swissprot:YECJ_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YECJ_ECOLI pepcoil swissprot:YECJ_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YECJ_ECOLI pepdigest swissprot:YECJ_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YECJ_ECOLI pepinfo swissprot:YECJ_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YECJ_ECOLI pepnet swissprot:YECJ_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YECJ_ECOLI pepstats swissprot:YECJ_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YECJ_ECOLI pepwheel swissprot:YECJ_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YECJ_ECOLI pepwindow swissprot:YECJ_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YECJ_ECOLI sigcleave swissprot:YECJ_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YECJ_ECOLI ## Database ID URL or Descriptions # BioGrid 4259740 13 # DISRUPTION PHENOTYPE Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain. {ECO:0000269|PubMed 20345943}. # EcoGene EG12326 yadL # FUNCTION YADL_ECOLI Part of the yadCKLM-htrE-yadVN fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. {ECO 0000269|PubMed 20345943}. # GO_component GO:0009289 pilus; IEA:UniProtKB-SubCell. # GO_process GO:0007155 cell adhesion; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_process GO:0007155 cell adhesion # Gene3D 2.60.40.1090 -; 1. # INDUCTION Repressed by H-NS. {ECO:0000269|PubMed 20345943}. # InterPro IPR000259 Adhesion_dom_fimbrial # InterPro IPR008966 Adhesion_dom # MISCELLANEOUS The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed. {ECO:0000305|PubMed 20345943}. # Organism YADL_ECOLI Escherichia coli (strain K12) # PATRIC 32115379 VBIEscCol129921_0141 # PIR A64737 A64737 # Pfam PF00419 Fimbrial # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YADL_ECOLI Uncharacterized fimbrial-like protein YadL # RefSeq NP_414679 NC_000913.3 # SIMILARITY Belongs to the fimbrial protein family. {ECO 0000305}. # SUBCELLULAR LOCATION YADL_ECOLI Fimbrium {ECO 0000305}. # SUPFAM SSF49401 SSF49401 # eggNOG ENOG4105SYG Bacteria # eggNOG ENOG411211N LUCA BLAST swissprot:YADL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YADL_ECOLI BioCyc ECOL316407:JW0133-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0133-MONOMER BioCyc EcoCyc:EG12326-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12326-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.9.1637 http://dx.doi.org/10.1093/nar/22.9.1637 DOI 10.1111/j.1462-2920.2010.02202.x http://dx.doi.org/10.1111/j.1462-2920.2010.02202.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2230 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2230 EcoGene EG12326 http://www.ecogene.org/geneInfo.php?eg_id=EG12326 EnsemblBacteria AAC73248 http://www.ensemblgenomes.org/id/AAC73248 EnsemblBacteria AAC73248 http://www.ensemblgenomes.org/id/AAC73248 EnsemblBacteria BAB96714 http://www.ensemblgenomes.org/id/BAB96714 EnsemblBacteria BAB96714 http://www.ensemblgenomes.org/id/BAB96714 EnsemblBacteria BAB96714 http://www.ensemblgenomes.org/id/BAB96714 EnsemblBacteria b0137 http://www.ensemblgenomes.org/id/b0137 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0009289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009289 GO_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_process GO:0007155 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007155 Gene3D 2.60.40.1090 http://www.cathdb.info/version/latest/superfamily/2.60.40.1090 GeneID 944829 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944829 HOGENOM HOG000116889 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000116889&db=HOGENOM6 InterPro IPR000259 http://www.ebi.ac.uk/interpro/entry/IPR000259 InterPro IPR008966 http://www.ebi.ac.uk/interpro/entry/IPR008966 KEGG_Gene ecj:JW0133 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0133 KEGG_Gene eco:b0137 http://www.genome.jp/dbget-bin/www_bget?eco:b0137 OMA MNARMVI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MNARMVI PSORT swissprot:YADL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YADL_ECOLI PSORT-B swissprot:YADL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YADL_ECOLI PSORT2 swissprot:YADL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YADL_ECOLI Pfam PF00419 http://pfam.xfam.org/family/PF00419 Phobius swissprot:YADL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YADL_ECOLI ProteinModelPortal P37017 http://www.proteinmodelportal.org/query/uniprot/P37017 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20345943 http://www.ncbi.nlm.nih.gov/pubmed/20345943 PubMed 8202364 http://www.ncbi.nlm.nih.gov/pubmed/8202364 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414679 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414679 STRING 511145.b0137 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0137&targetmode=cogs SUPFAM SSF49401 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49401 UniProtKB YADL_ECOLI http://www.uniprot.org/uniprot/YADL_ECOLI UniProtKB-AC P37017 http://www.uniprot.org/uniprot/P37017 charge swissprot:YADL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YADL_ECOLI eggNOG ENOG4105SYG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105SYG eggNOG ENOG411211N http://eggnogapi.embl.de/nog_data/html/tree/ENOG411211N epestfind swissprot:YADL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YADL_ECOLI garnier swissprot:YADL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YADL_ECOLI helixturnhelix swissprot:YADL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YADL_ECOLI hmoment swissprot:YADL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YADL_ECOLI iep swissprot:YADL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YADL_ECOLI inforesidue swissprot:YADL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YADL_ECOLI octanol swissprot:YADL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YADL_ECOLI pepcoil swissprot:YADL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YADL_ECOLI pepdigest swissprot:YADL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YADL_ECOLI pepinfo swissprot:YADL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YADL_ECOLI pepnet swissprot:YADL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YADL_ECOLI pepstats swissprot:YADL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YADL_ECOLI pepwheel swissprot:YADL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YADL_ECOLI pepwindow swissprot:YADL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YADL_ECOLI sigcleave swissprot:YADL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YADL_ECOLI ## Database ID URL or Descriptions # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG40121 insO # FUNCTION INSO2_ECOLI Involved in the transposition of the insertion sequence IS911B. # GO_function GO:0003677 DNA binding; IEA:UniProtKB-KW. # GO_process GO:0006310 DNA recombination; IEA:UniProtKB-KW. # GO_process GO:0015074 DNA integration; IEA:InterPro. # GO_process GO:0032196 transposition; IEA:UniProtKB-KW. # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # Gene3D 3.30.420.10 -; 1. # IntAct Q47718 5 # InterPro IPR001584 Integrase_cat-core # InterPro IPR012337 RNaseH-like_dom # Organism INSO2_ECOLI Escherichia coli (strain K12) # PIR S56510 S56510 # PROSITE PS50994 INTEGRASE # Pfam PF00665 rve # Proteomes UP000000625 Chromosome # RecName INSO2_ECOLI Putative transposase InsO for insertion sequence element IS911B # SIMILARITY Contains 1 integrase catalytic domain. {ECO:0000255|PROSITE-ProRule PRU00457}. # SUPFAM SSF53098 SSF53098 # eggNOG COG2801 LUCA BLAST swissprot:INSO2_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSO2_ECOLI BioCyc EcoCyc:G7906-MONOMER http://biocyc.org/getid?id=EcoCyc:G7906-MONOMER DIP DIP-28090N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-28090N DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB4747 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4747 EcoGene EG40121 http://www.ecogene.org/geneInfo.php?eg_id=EG40121 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_process GO:0006310 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006310 GO_process GO:0015074 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015074 GO_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 Gene3D 3.30.420.10 http://www.cathdb.info/version/latest/superfamily/3.30.420.10 InParanoid Q47718 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=Q47718 IntAct Q47718 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=Q47718* InterPro IPR001584 http://www.ebi.ac.uk/interpro/entry/IPR001584 InterPro IPR012337 http://www.ebi.ac.uk/interpro/entry/IPR012337 OMA YRTRELM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YRTRELM PROSITE PS50994 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50994 PSORT swissprot:INSO2_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSO2_ECOLI PSORT-B swissprot:INSO2_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSO2_ECOLI PSORT2 swissprot:INSO2_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSO2_ECOLI Pfam PF00665 http://pfam.xfam.org/family/PF00665 Phobius swissprot:INSO2_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSO2_ECOLI PhylomeDB Q47718 http://phylomedb.org/?seqid=Q47718 ProteinModelPortal Q47718 http://www.proteinmodelportal.org/query/uniprot/Q47718 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 SMR Q47718 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=Q47718 STRING 316407.85674401 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=316407.85674401&targetmode=cogs SUPFAM SSF53098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098 UniProtKB INSO2_ECOLI http://www.uniprot.org/uniprot/INSO2_ECOLI UniProtKB-AC Q47718 http://www.uniprot.org/uniprot/Q47718 charge swissprot:INSO2_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSO2_ECOLI eggNOG COG2801 http://eggnogapi.embl.de/nog_data/html/tree/COG2801 epestfind swissprot:INSO2_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSO2_ECOLI garnier swissprot:INSO2_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSO2_ECOLI helixturnhelix swissprot:INSO2_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSO2_ECOLI hmoment swissprot:INSO2_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSO2_ECOLI iep swissprot:INSO2_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSO2_ECOLI inforesidue swissprot:INSO2_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSO2_ECOLI octanol swissprot:INSO2_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSO2_ECOLI pepcoil swissprot:INSO2_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSO2_ECOLI pepdigest swissprot:INSO2_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSO2_ECOLI pepinfo swissprot:INSO2_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSO2_ECOLI pepnet swissprot:INSO2_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSO2_ECOLI pepstats swissprot:INSO2_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSO2_ECOLI pepwheel swissprot:INSO2_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSO2_ECOLI pepwindow swissprot:INSO2_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSO2_ECOLI sigcleave swissprot:INSO2_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSO2_ECOLI ## Database ID URL or Descriptions # AltName NADPH quinone reductase 1 # AltName QOR1_ECOLI Zeta-crystallin homolog protein # BioGrid 4260805 6 # CATALYTIC ACTIVITY QOR1_ECOLI NADPH + 2 quinone = NADP(+) + 2 semiquinone. # EcoGene EG11492 qorA # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0008270 zinc ion binding; IEA:InterPro. # GO_function GO:0017091 AU-rich element binding; IBA:GO_Central. # GO_function QOR1_ECOLI GO 0003960 NADPH quinone reductase activity; IBA GO_Central. # GO_process GO:0034599 cellular response to oxidative stress; IBA:GO_Central. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # Gene3D 3.40.50.720 -; 1. # Gene3D 3.90.180.10 -; 1. # IntAct P28304 5 # InterPro IPR002085 ADH_SF_Zn-type # InterPro IPR002364 Quin_OxRdtase/zeta-crystal_CS # InterPro IPR011032 GroES-like # InterPro IPR013149 ADH_C # InterPro IPR013154 ADH_N # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR020843 PKS_ER # KEGG_Brite ko01000 Enzymes # Organism QOR1_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11695 PTHR11695 # PATRIC 32123641 VBIEscCol129921_4169 # PDB 1QOR X-ray; 2.20 A; A/B=1-327 # PIR S45529 S45529 # PROSITE PS01162 QOR_ZETA_CRYSTAL # Pfam PF00107 ADH_zinc_N # Pfam PF08240 ADH_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName QOR1_ECOLI Quinone oxidoreductase 1 # RefSeq NP_418475 NC_000913.3 # RefSeq WP_000235508 NZ_LN832404.1 # SIMILARITY Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. {ECO 0000305}. # SMART SM00829 PKS_ER # SUBUNIT Homodimer. {ECO:0000269|PubMed 7602590}. # SUPFAM SSF50129 SSF50129 # SUPFAM SSF51735 SSF51735 # eggNOG COG0604 LUCA # eggNOG ENOG4105EE6 Bacteria BLAST swissprot:QOR1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:QOR1_ECOLI BioCyc ECOL316407:JW4011-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4011-MONOMER BioCyc EcoCyc:QOR-MONOMER http://biocyc.org/getid?id=EcoCyc:QOR-MONOMER BioCyc MetaCyc:QOR-MONOMER http://biocyc.org/getid?id=MetaCyc:QOR-MONOMER COG COG0604 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0604 DIP DIP-10631N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10631N DOI 10.1006/jmbi.1995.0337 http://dx.doi.org/10.1006/jmbi.1995.0337 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.6.5.5 http://www.genome.jp/dbget-bin/www_bget?EC:1.6.5.5 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L02312 http://www.ebi.ac.uk/ena/data/view/L02312 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.6.5.5 http://enzyme.expasy.org/EC/1.6.5.5 EchoBASE EB1455 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1455 EcoGene EG11492 http://www.ecogene.org/geneInfo.php?eg_id=EG11492 EnsemblBacteria AAC77021 http://www.ensemblgenomes.org/id/AAC77021 EnsemblBacteria AAC77021 http://www.ensemblgenomes.org/id/AAC77021 EnsemblBacteria BAE78053 http://www.ensemblgenomes.org/id/BAE78053 EnsemblBacteria BAE78053 http://www.ensemblgenomes.org/id/BAE78053 EnsemblBacteria BAE78053 http://www.ensemblgenomes.org/id/BAE78053 EnsemblBacteria b4051 http://www.ensemblgenomes.org/id/b4051 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003960 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003960 GO_function GO:0008270 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270 GO_function GO:0017091 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017091 GO_process GO:0034599 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034599 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 Gene3D 3.90.180.10 http://www.cathdb.info/version/latest/superfamily/3.90.180.10 GeneID 948556 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948556 HOGENOM HOG000294672 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000294672&db=HOGENOM6 InParanoid P28304 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P28304 IntAct P28304 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P28304* IntEnz 1.6.5.5 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.6.5.5 InterPro IPR002085 http://www.ebi.ac.uk/interpro/entry/IPR002085 InterPro IPR002364 http://www.ebi.ac.uk/interpro/entry/IPR002364 InterPro IPR011032 http://www.ebi.ac.uk/interpro/entry/IPR011032 InterPro IPR013149 http://www.ebi.ac.uk/interpro/entry/IPR013149 InterPro IPR013154 http://www.ebi.ac.uk/interpro/entry/IPR013154 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR020843 http://www.ebi.ac.uk/interpro/entry/IPR020843 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW4011 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4011 KEGG_Gene eco:b4051 http://www.genome.jp/dbget-bin/www_bget?eco:b4051 KEGG_Orthology KO:K00344 http://www.genome.jp/dbget-bin/www_bget?KO:K00344 MINT MINT-1267314 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1267314 OMA TDGKKCP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TDGKKCP PANTHER PTHR11695 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11695 PDB 1QOR http://www.ebi.ac.uk/pdbe-srv/view/entry/1QOR PDBsum 1QOR http://www.ebi.ac.uk/pdbsum/1QOR PROSITE PS01162 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01162 PSORT swissprot:QOR1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:QOR1_ECOLI PSORT-B swissprot:QOR1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:QOR1_ECOLI PSORT2 swissprot:QOR1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:QOR1_ECOLI Pfam PF00107 http://pfam.xfam.org/family/PF00107 Pfam PF08240 http://pfam.xfam.org/family/PF08240 Phobius swissprot:QOR1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:QOR1_ECOLI PhylomeDB P28304 http://phylomedb.org/?seqid=P28304 ProteinModelPortal P28304 http://www.proteinmodelportal.org/query/uniprot/P28304 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7602590 http://www.ncbi.nlm.nih.gov/pubmed/7602590 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418475 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418475 RefSeq WP_000235508 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000235508 SMART SM00829 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00829 SMR P28304 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P28304 STRING 511145.b4051 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4051&targetmode=cogs STRING COG0604 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0604&targetmode=cogs SUPFAM SSF50129 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50129 SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB QOR1_ECOLI http://www.uniprot.org/uniprot/QOR1_ECOLI UniProtKB-AC P28304 http://www.uniprot.org/uniprot/P28304 charge swissprot:QOR1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:QOR1_ECOLI eggNOG COG0604 http://eggnogapi.embl.de/nog_data/html/tree/COG0604 eggNOG ENOG4105EE6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EE6 epestfind swissprot:QOR1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:QOR1_ECOLI garnier swissprot:QOR1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:QOR1_ECOLI helixturnhelix swissprot:QOR1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:QOR1_ECOLI hmoment swissprot:QOR1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:QOR1_ECOLI iep swissprot:QOR1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:QOR1_ECOLI inforesidue swissprot:QOR1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:QOR1_ECOLI octanol swissprot:QOR1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:QOR1_ECOLI pepcoil swissprot:QOR1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:QOR1_ECOLI pepdigest swissprot:QOR1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:QOR1_ECOLI pepinfo swissprot:QOR1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:QOR1_ECOLI pepnet swissprot:QOR1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:QOR1_ECOLI pepstats swissprot:QOR1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:QOR1_ECOLI pepwheel swissprot:QOR1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:QOR1_ECOLI pepwindow swissprot:QOR1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:QOR1_ECOLI sigcleave swissprot:QOR1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:QOR1_ECOLI ## Database ID URL or Descriptions # AltName GHRA_ECOLI 2-ketoacid reductase # BIOPHYSICOCHEMICAL PROPERTIES GHRA_ECOLI Kinetic parameters KM=0.6 mM for glyoxylate (at 25 degrees Celsius and pH 7) {ECO 0000269|PubMed 11237876}; KM=1.0 mM for hydroxypyruvate (at 25 degrees Celsius and pH 7) {ECO 0000269|PubMed 11237876}; Vmax=120 umol/min/mg enzyme with glyoxylate as substrate (at 25 degrees Celsius and pH 7) {ECO 0000269|PubMed 11237876}; Vmax=20 umol/min/mg enzyme with hydroxypyruvate as substrate (at 25 degrees Celsius and pH 7) {ECO 0000269|PubMed 11237876}; Note=The catalytic efficiency is better for glyoxylate than hydroxypyruvate with NADPH as electron donor.; pH dependence Optimum pH is 7.0. {ECO 0000269|PubMed 11237876}; # BioGrid 4260060 17 # CATALYTIC ACTIVITY D-glycerate + NAD(P)(+) = hydroxypyruvate + NAD(P)H. {ECO:0000269|PubMed 11237876}. # CATALYTIC ACTIVITY Glycolate + NADP(+) = glyoxylate + NADPH. {ECO:0000269|PubMed 11237876}. # EcoGene EG13869 ghrA # FUNCTION GHRA_ECOLI Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. Inactive towards 2-oxo-D-gluconate, 2-oxoglutarate, oxaloacetate and pyruvate. Only D- and L-glycerate are involved in the oxidative activity with NADP. Activity with NAD is very low. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-HAMAP. # GO_function GO:0016618 hydroxypyruvate reductase activity; IDA:EcoCyc. # GO_function GO:0030267 glyoxylate reductase (NADP) activity; IDA:EcoCyc. # GO_function GO:0051287 NAD binding; IEA:InterPro. # GOslim_component GO:0005829 cytosol # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # Gene3D 3.40.50.720 -; 1. # HAMAP MF_01666 2_Hacid_dh_C_GhrA # INDUCTION Constitutively expressed. {ECO:0000269|PubMed 11237876}. # InterPro IPR006140 D-isomer_DH_NAD-bd # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR023514 GhrA # InterPro IPR029753 D-isomer_DH_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00260 Glycine, serine and threonine metabolism # KEGG_Pathway ko00620 Pyruvate metabolism # KEGG_Pathway ko00630 Glyoxylate and dicarboxylate metabolism # Organism GHRA_ECOLI Escherichia coli (strain K12) # PATRIC 32117297 VBIEscCol129921_1071 # PIR F64845 F64845 # PROSITE PS00671 D_2_HYDROXYACID_DH_3 # Pfam PF02826 2-Hacid_dh_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName GHRA_ECOLI Glyoxylate/hydroxypyruvate reductase A # RefSeq NP_415551 NC_000913.3 # RefSeq WP_000351317 NZ_LN832404.1 # SIMILARITY Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION GHRA_ECOLI Cytoplasm {ECO 0000305|PubMed 11237876}. # SUPFAM SSF51735 SSF51735 # eggNOG COG0111 LUCA # eggNOG ENOG4105JPG Bacteria BLAST swissprot:GHRA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GHRA_ECOLI BioCyc ECOL316407:JW5146-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5146-MONOMER BioCyc EcoCyc:G6539-MONOMER http://biocyc.org/getid?id=EcoCyc:G6539-MONOMER BioCyc MetaCyc:G6539-MONOMER http://biocyc.org/getid?id=MetaCyc:G6539-MONOMER COG COG0111 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0111 DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/0264-6021:3540707 http://dx.doi.org/10.1042/0264-6021:3540707 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.1.1.79 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.79 EC_number EC:1.1.1.81 http://www.genome.jp/dbget-bin/www_bget?EC:1.1.1.81 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.1.1.79 http://enzyme.expasy.org/EC/1.1.1.79 ENZYME 1.1.1.81 http://enzyme.expasy.org/EC/1.1.1.81 EchoBASE EB3628 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3628 EcoGene EG13869 http://www.ecogene.org/geneInfo.php?eg_id=EG13869 EnsemblBacteria AAC74117 http://www.ensemblgenomes.org/id/AAC74117 EnsemblBacteria AAC74117 http://www.ensemblgenomes.org/id/AAC74117 EnsemblBacteria BAA35814 http://www.ensemblgenomes.org/id/BAA35814 EnsemblBacteria BAA35814 http://www.ensemblgenomes.org/id/BAA35814 EnsemblBacteria BAA35814 http://www.ensemblgenomes.org/id/BAA35814 EnsemblBacteria b1033 http://www.ensemblgenomes.org/id/b1033 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0016618 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016618 GO_function GO:0030267 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030267 GO_function GO:0051287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051287 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 GeneID 946431 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946431 HAMAP MF_01666 http://hamap.expasy.org/unirule/MF_01666 HOGENOM HOG000136694 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000136694&db=HOGENOM6 InParanoid P75913 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75913 IntAct P75913 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P75913* IntEnz 1.1.1.79 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.79 IntEnz 1.1.1.81 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.1.1.81 InterPro IPR006140 http://www.ebi.ac.uk/interpro/entry/IPR006140 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR023514 http://www.ebi.ac.uk/interpro/entry/IPR023514 InterPro IPR029753 http://www.ebi.ac.uk/interpro/entry/IPR029753 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5146 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5146 KEGG_Gene eco:b1033 http://www.genome.jp/dbget-bin/www_bget?eco:b1033 KEGG_Orthology KO:K12972 http://www.genome.jp/dbget-bin/www_bget?KO:K12972 KEGG_Pathway ko00260 http://www.genome.jp/kegg-bin/show_pathway?ko00260 KEGG_Pathway ko00620 http://www.genome.jp/kegg-bin/show_pathway?ko00620 KEGG_Pathway ko00630 http://www.genome.jp/kegg-bin/show_pathway?ko00630 KEGG_Reaction rn:R00465 http://www.genome.jp/dbget-bin/www_bget?rn:R00465 KEGG_Reaction rn:R01388 http://www.genome.jp/dbget-bin/www_bget?rn:R01388 KEGG_Reaction rn:R01392 http://www.genome.jp/dbget-bin/www_bget?rn:R01392 KEGG_Reaction rn:R02527 http://www.genome.jp/dbget-bin/www_bget?rn:R02527 OMA LLISSHC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LLISSHC PROSITE PS00671 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00671 PSORT swissprot:GHRA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GHRA_ECOLI PSORT-B swissprot:GHRA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GHRA_ECOLI PSORT2 swissprot:GHRA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GHRA_ECOLI Pfam PF02826 http://pfam.xfam.org/family/PF02826 Phobius swissprot:GHRA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GHRA_ECOLI PhylomeDB P75913 http://phylomedb.org/?seqid=P75913 ProteinModelPortal P75913 http://www.proteinmodelportal.org/query/uniprot/P75913 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 11237876 http://www.ncbi.nlm.nih.gov/pubmed/11237876 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415551 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415551 RefSeq WP_000351317 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000351317 SMR P75913 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75913 STRING 511145.b1033 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1033&targetmode=cogs STRING COG0111 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0111&targetmode=cogs SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 UniProtKB GHRA_ECOLI http://www.uniprot.org/uniprot/GHRA_ECOLI UniProtKB-AC P75913 http://www.uniprot.org/uniprot/P75913 charge swissprot:GHRA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GHRA_ECOLI eggNOG COG0111 http://eggnogapi.embl.de/nog_data/html/tree/COG0111 eggNOG ENOG4105JPG http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105JPG epestfind swissprot:GHRA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GHRA_ECOLI garnier swissprot:GHRA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GHRA_ECOLI helixturnhelix swissprot:GHRA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GHRA_ECOLI hmoment swissprot:GHRA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GHRA_ECOLI iep swissprot:GHRA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GHRA_ECOLI inforesidue swissprot:GHRA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GHRA_ECOLI octanol swissprot:GHRA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GHRA_ECOLI pepcoil swissprot:GHRA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GHRA_ECOLI pepdigest swissprot:GHRA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GHRA_ECOLI pepinfo swissprot:GHRA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GHRA_ECOLI pepnet swissprot:GHRA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GHRA_ECOLI pepstats swissprot:GHRA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GHRA_ECOLI pepwheel swissprot:GHRA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GHRA_ECOLI pepwindow swissprot:GHRA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GHRA_ECOLI sigcleave swissprot:GHRA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GHRA_ECOLI ## Database ID URL or Descriptions # AltName HMP_ECOLI Flavohemoglobin # AltName HMP_ECOLI HMP # AltName HMP_ECOLI Hemoglobin-like protein # AltName HMP_ECOLI Nitric oxide dioxygenase # BIOPHYSICOCHEMICAL PROPERTIES HMP_ECOLI Kinetic parameters KM=0.28 uM for NO {ECO 0000269|PubMed 10777548}; KM=90 uM for O(2) {ECO 0000269|PubMed 10777548}; KM=1.8 uM for NADH {ECO 0000269|PubMed 10777548}; KM=19.6 uM for NADPH {ECO 0000269|PubMed 10777548}; # BRENDA 1.14.12.17 2026 # BioGrid 4259200 11 # CATALYTIC ACTIVITY 2 nitric oxide + 2 O(2) + NAD(P)H = 2 nitrate + NAD(P)(+) + H(+). {ECO:0000269|PubMed 11751864}. # COFACTOR Name=FAD; Xref=ChEBI:CHEBI 57692; Note=Binds 1 FAD per subunit.; # COFACTOR Name=heme b; Xref=ChEBI:CHEBI 60344; Note=Binds 1 heme b group per subunit.; # DOMAIN HMP_ECOLI Consists of two distinct domains; an N-terminal heme- containing oxygen-binding domain and a C-terminal reductase domain with binding sites for FAD and NAD(P)H. # DrugBank DB03147 Flavin adenine dinucleotide # EcoGene EG10456 hmp # FUNCTION HMP_ECOLI In the presence of oxygen and NADH, HMP has NADH oxidase activity, which leads to the generation of superoxide and H(2)O(2), both in vitro and in vivo, and it has been suggested that HMP might act as an amplifier of superoxide stress. Under anaerobic conditions, HMP also exhibits nitric oxide reductase and FAD reductase activities. However, all these reactions are much lower than NOD activity. # FUNCTION HMP_ECOLI Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress. # FUNCTION HMP_ECOLI Various electron acceptors are also reduced by HMP in vitro, including dihydropterine, ferrisiderophores, ferric citrate, cytochrome c, nitrite, S-nitrosoglutathione, and alkylhydroperoxides. However, it is unknown if these reactions are of any biological significance in vivo. # GO_component GO:0005622 intracellular; IBA:GO_Central. # GO_component GO:0005737 cytoplasm; IEA:UniProtKB-SubCell. # GO_function GO:0005344 oxygen transporter activity; IEA:UniProtKB-HAMAP. # GO_function GO:0005504 fatty acid binding; IDA:EcoCyc. # GO_function GO:0008941 nitric oxide dioxygenase activity; IDA:EcoCyc. # GO_function GO:0019825 oxygen binding; IEA:InterPro. # GO_function GO:0020037 heme binding; IDA:EcoCyc. # GO_function GO:0032843 hydroperoxide reductase activity; IDA:EcoCyc. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0071949 FAD binding; IDA:EcoCyc. # GO_process GO:0009636 response to toxic substance; IEA:UniProtKB-KW. # GO_process GO:0046210 nitric oxide catabolic process; IBA:GO_Central. # GO_process GO:0051409 response to nitrosative stress; IMP:EcoCyc. # GO_process GO:0071500 cellular response to nitrosative stress; IBA:GO_Central. # GOslim_component GO:0005622 intracellular # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008289 lipid binding # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006950 response to stress # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.490.10 -; 1. # HAMAP MF_01252 Hmp # INDUCTION HMP_ECOLI By nitric oxyde NO (under aerobic conditions), nitrite, nitrate (under anaerobic conditions), nitroso compounds, and paraquat. {ECO 0000269|PubMed 8808940, ECO 0000269|PubMed 9150210, ECO 0000269|PubMed 9767577}. # IntAct P24232 4 # InterPro IPR000971 Globin # InterPro IPR001221 Phe_hydroxylase # InterPro IPR001433 OxRdtase_FAD/NAD-bd # InterPro IPR008333 OxRdtase_FAD-bd_dom # InterPro IPR009050 Globin-like # InterPro IPR012292 Globin/Proto # InterPro IPR017927 Fd_Rdtase_FAD-bd # InterPro IPR017938 Riboflavin_synthase-like_b-brl # InterPro IPR023950 Hmp # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko05132 Salmonella infection # MISCELLANEOUS HMP_ECOLI HMP is able to bind specifically unsaturated and/or cyclopropanated fatty acids with high affinity. # MISCELLANEOUS HMP_ECOLI No protein-heme interactions have been detected at the distal side of the heme molecule. # Organism HMP_ECOLI Escherichia coli (strain K12) # PATRIC 32120503 VBIEscCol129921_2654 # PDB 1GVH X-ray; 2.19 A; A=1-396 # PIR S15992 S15992 # PRINTS PR00410 PHEHYDRXLASE # PROSITE PS01033 GLOBIN # PROSITE PS51384 FAD_FR # Pfam PF00042 Globin # Pfam PF00175 NAD_binding_1 # Pfam PF00970 FAD_binding_6 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HMP_ECOLI Flavohemoprotein # RefSeq NP_417047 NC_000913.3 # RefSeq WP_000883122 NZ_LN832404.1 # SIMILARITY Belongs to the globin family. Two-domain flavohemoproteins subfamily. {ECO 0000305}. # SIMILARITY Contains 1 FAD-binding FR-type domain. {ECO 0000305}. # SIMILARITY In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. {ECO 0000305}. # SUBCELLULAR LOCATION HMP_ECOLI Cytoplasm {ECO 0000269|PubMed 7875569}. Note=Has also been found to localize into the periplasm, but spectral analysis revealed that biochemically active HMP is exclusively found in the cytoplasmic fraction. # SUBUNIT HMP_ECOLI Monomer. # SUPFAM SSF46458 SSF46458 # SUPFAM SSF63380 SSF63380 # eggNOG COG1017 LUCA # eggNOG COG1018 LUCA # eggNOG ENOG4105CJJ Bacteria BLAST swissprot:HMP_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HMP_ECOLI BioCyc ECOL316407:JW2536-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2536-MONOMER BioCyc EcoCyc:EG10456-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10456-MONOMER BioCyc MetaCyc:EG10456-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10456-MONOMER COG COG1017 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1017 COG COG1018 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1018 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/bbrc.1994.1018 http://dx.doi.org/10.1006/bbrc.1994.1018 DOI 10.1007/BF00273586 http://dx.doi.org/10.1007/BF00273586 DOI 10.1016/0014-5793(92)80452-M http://dx.doi.org/10.1016/0014-5793(92)80452-M DOI 10.1016/0014-5793(96)00154-8 http://dx.doi.org/10.1016/0014-5793(96)00154-8 DOI 10.1016/0378-1119(83)90059-8 http://dx.doi.org/10.1016/0378-1119(83)90059-8 DOI 10.1016/S0006-291X(05)81463-9 http://dx.doi.org/10.1016/S0006-291X(05)81463-9 DOI 10.1016/S0014-5793(99)00157-X http://dx.doi.org/10.1016/S0014-5793(99)00157-X DOI 10.1016/S0167-4838(01)00256-4 http://dx.doi.org/10.1016/S0167-4838(01)00256-4 DOI 10.1016/S0168-6445(03)00056-1 http://dx.doi.org/10.1016/S0168-6445(03)00056-1 DOI 10.1021/bi0206311 http://dx.doi.org/10.1021/bi0206311 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/0264-6021:3530207 http://dx.doi.org/10.1042/0264-6021:3530207 DOI 10.1046/j.1365-2958.1998.01000.x http://dx.doi.org/10.1046/j.1365-2958.1998.01000.x DOI 10.1046/j.1365-2958.2000.01889.x http://dx.doi.org/10.1046/j.1365-2958.2000.01889.x DOI 10.1073/pnas.181199698 http://dx.doi.org/10.1073/pnas.181199698 DOI 10.1073/pnas.95.18.10378 http://dx.doi.org/10.1073/pnas.95.18.10378 DOI 10.1073/pnas.95.24.14100 http://dx.doi.org/10.1073/pnas.95.24.14100 DOI 10.1074/jbc.273.41.26528 http://dx.doi.org/10.1074/jbc.273.41.26528 DOI 10.1074/jbc.274.2.748 http://dx.doi.org/10.1074/jbc.274.2.748 DOI 10.1074/jbc.275.17.12581 http://dx.doi.org/10.1074/jbc.275.17.12581 DOI 10.1074/jbc.M002471200 http://dx.doi.org/10.1074/jbc.M002471200 DOI 10.1074/jbc.M004141200 http://dx.doi.org/10.1074/jbc.M004141200 DOI 10.1074/jbc.M009280200 http://dx.doi.org/10.1074/jbc.M009280200 DOI 10.1074/jbc.M110470200 http://dx.doi.org/10.1074/jbc.M110470200 DOI 10.1074/jbc.M202228200 http://dx.doi.org/10.1074/jbc.M202228200 DOI 10.1074/jbc.M301285200 http://dx.doi.org/10.1074/jbc.M301285200 DOI 10.1074/jbc.M303282200 http://dx.doi.org/10.1074/jbc.M303282200 DOI 10.1074/jbc.M303629200 http://dx.doi.org/10.1074/jbc.M303629200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1099/00221287-143-5-1557 http://dx.doi.org/10.1099/00221287-143-5-1557 DOI 10.1099/13500872-142-5-1141 http://dx.doi.org/10.1099/13500872-142-5-1141 DOI 10.1111/j.1574-6968.1995.tb07361.x http://dx.doi.org/10.1111/j.1574-6968.1995.tb07361.x DOI 10.1111/j.1574-6968.1998.tb13893.x http://dx.doi.org/10.1111/j.1574-6968.1998.tb13893.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB03147 http://www.drugbank.ca/drugs/DB03147 EC_number EC:1.14.12.17 http://www.genome.jp/dbget-bin/www_bget?EC:1.14.12.17 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01620 http://www.ebi.ac.uk/ena/data/view/J01620 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X58872 http://www.ebi.ac.uk/ena/data/view/X58872 ENZYME 1.14.12.17 http://enzyme.expasy.org/EC/1.14.12.17 EchoBASE EB0451 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0451 EcoGene EG10456 http://www.ecogene.org/geneInfo.php?eg_id=EG10456 EnsemblBacteria AAC75605 http://www.ensemblgenomes.org/id/AAC75605 EnsemblBacteria AAC75605 http://www.ensemblgenomes.org/id/AAC75605 EnsemblBacteria BAA16460 http://www.ensemblgenomes.org/id/BAA16460 EnsemblBacteria BAA16460 http://www.ensemblgenomes.org/id/BAA16460 EnsemblBacteria BAA16460 http://www.ensemblgenomes.org/id/BAA16460 EnsemblBacteria b2552 http://www.ensemblgenomes.org/id/b2552 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0005344 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005344 GO_function GO:0005504 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005504 GO_function GO:0008941 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008941 GO_function GO:0019825 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019825 GO_function GO:0020037 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0020037 GO_function GO:0032843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032843 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0071949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071949 GO_process GO:0009636 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009636 GO_process GO:0046210 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046210 GO_process GO:0051409 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051409 GO_process GO:0071500 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071500 GOslim_component GO:0005622 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008289 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008289 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.490.10 http://www.cathdb.info/version/latest/superfamily/1.10.490.10 GeneID 947018 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947018 HAMAP MF_01252 http://hamap.expasy.org/unirule/MF_01252 HOGENOM HOG000238921 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000238921&db=HOGENOM6 InParanoid P24232 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P24232 IntAct P24232 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P24232* IntEnz 1.14.12.17 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.14.12.17 InterPro IPR000971 http://www.ebi.ac.uk/interpro/entry/IPR000971 InterPro IPR001221 http://www.ebi.ac.uk/interpro/entry/IPR001221 InterPro IPR001433 http://www.ebi.ac.uk/interpro/entry/IPR001433 InterPro IPR008333 http://www.ebi.ac.uk/interpro/entry/IPR008333 InterPro IPR009050 http://www.ebi.ac.uk/interpro/entry/IPR009050 InterPro IPR012292 http://www.ebi.ac.uk/interpro/entry/IPR012292 InterPro IPR017927 http://www.ebi.ac.uk/interpro/entry/IPR017927 InterPro IPR017938 http://www.ebi.ac.uk/interpro/entry/IPR017938 InterPro IPR023950 http://www.ebi.ac.uk/interpro/entry/IPR023950 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2536 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2536 KEGG_Gene eco:b2552 http://www.genome.jp/dbget-bin/www_bget?eco:b2552 KEGG_Orthology KO:K05916 http://www.genome.jp/dbget-bin/www_bget?KO:K05916 KEGG_Pathway ko05132 http://www.genome.jp/kegg-bin/show_pathway?ko05132 OMA DQYQIVG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=DQYQIVG PDB 1GVH http://www.ebi.ac.uk/pdbe-srv/view/entry/1GVH PDBsum 1GVH http://www.ebi.ac.uk/pdbsum/1GVH PRINTS PR00410 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00410 PROSITE PS01033 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01033 PROSITE PS51384 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51384 PSORT swissprot:HMP_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HMP_ECOLI PSORT-B swissprot:HMP_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HMP_ECOLI PSORT2 swissprot:HMP_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HMP_ECOLI Pfam PF00042 http://pfam.xfam.org/family/PF00042 Pfam PF00175 http://pfam.xfam.org/family/PF00175 Pfam PF00970 http://pfam.xfam.org/family/PF00970 Phobius swissprot:HMP_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HMP_ECOLI PhylomeDB P24232 http://phylomedb.org/?seqid=P24232 ProteinModelPortal P24232 http://www.proteinmodelportal.org/query/uniprot/P24232 PubMed 10094495 http://www.ncbi.nlm.nih.gov/pubmed/10094495 PubMed 10777548 http://www.ncbi.nlm.nih.gov/pubmed/10777548 PubMed 10844666 http://www.ncbi.nlm.nih.gov/pubmed/10844666 PubMed 10915782 http://www.ncbi.nlm.nih.gov/pubmed/10915782 PubMed 10922365 http://www.ncbi.nlm.nih.gov/pubmed/10922365 PubMed 11092893 http://www.ncbi.nlm.nih.gov/pubmed/11092893 PubMed 11139382 http://www.ncbi.nlm.nih.gov/pubmed/11139382 PubMed 11517313 http://www.ncbi.nlm.nih.gov/pubmed/11517313 PubMed 11690654 http://www.ncbi.nlm.nih.gov/pubmed/11690654 PubMed 11751864 http://www.ncbi.nlm.nih.gov/pubmed/11751864 PubMed 11964402 http://www.ncbi.nlm.nih.gov/pubmed/11964402 PubMed 12663656 http://www.ncbi.nlm.nih.gov/pubmed/12663656 PubMed 12741837 http://www.ncbi.nlm.nih.gov/pubmed/12741837 PubMed 12783887 http://www.ncbi.nlm.nih.gov/pubmed/12783887 PubMed 12826671 http://www.ncbi.nlm.nih.gov/pubmed/12826671 PubMed 1325799 http://www.ncbi.nlm.nih.gov/pubmed/1325799 PubMed 14550944 http://www.ncbi.nlm.nih.gov/pubmed/14550944 PubMed 1601132 http://www.ncbi.nlm.nih.gov/pubmed/1601132 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2034230 http://www.ncbi.nlm.nih.gov/pubmed/2034230 PubMed 6190704 http://www.ncbi.nlm.nih.gov/pubmed/6190704 PubMed 7875569 http://www.ncbi.nlm.nih.gov/pubmed/7875569 PubMed 8292013 http://www.ncbi.nlm.nih.gov/pubmed/8292013 PubMed 8612736 http://www.ncbi.nlm.nih.gov/pubmed/8612736 PubMed 8704956 http://www.ncbi.nlm.nih.gov/pubmed/8704956 PubMed 8808940 http://www.ncbi.nlm.nih.gov/pubmed/8808940 PubMed 9150210 http://www.ncbi.nlm.nih.gov/pubmed/9150210 PubMed 9168606 http://www.ncbi.nlm.nih.gov/pubmed/9168606 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9724711 http://www.ncbi.nlm.nih.gov/pubmed/9724711 PubMed 9756889 http://www.ncbi.nlm.nih.gov/pubmed/9756889 PubMed 9767577 http://www.ncbi.nlm.nih.gov/pubmed/9767577 PubMed 9770277 http://www.ncbi.nlm.nih.gov/pubmed/9770277 PubMed 9826660 http://www.ncbi.nlm.nih.gov/pubmed/9826660 PubMed 9873011 http://www.ncbi.nlm.nih.gov/pubmed/9873011 RefSeq NP_417047 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417047 RefSeq WP_000883122 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000883122 SMR P24232 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P24232 STRING 511145.b2552 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2552&targetmode=cogs STRING COG1017 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1017&targetmode=cogs STRING COG1018 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1018&targetmode=cogs SUPFAM SSF46458 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46458 SUPFAM SSF63380 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF63380 UniProtKB HMP_ECOLI http://www.uniprot.org/uniprot/HMP_ECOLI UniProtKB-AC P24232 http://www.uniprot.org/uniprot/P24232 charge swissprot:HMP_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HMP_ECOLI eggNOG COG1017 http://eggnogapi.embl.de/nog_data/html/tree/COG1017 eggNOG COG1018 http://eggnogapi.embl.de/nog_data/html/tree/COG1018 eggNOG ENOG4105CJJ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CJJ epestfind swissprot:HMP_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HMP_ECOLI garnier swissprot:HMP_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HMP_ECOLI helixturnhelix swissprot:HMP_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HMP_ECOLI hmoment swissprot:HMP_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HMP_ECOLI iep swissprot:HMP_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HMP_ECOLI inforesidue swissprot:HMP_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HMP_ECOLI octanol swissprot:HMP_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HMP_ECOLI pepcoil swissprot:HMP_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HMP_ECOLI pepdigest swissprot:HMP_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HMP_ECOLI pepinfo swissprot:HMP_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HMP_ECOLI pepnet swissprot:HMP_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HMP_ECOLI pepstats swissprot:HMP_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HMP_ECOLI pepwheel swissprot:HMP_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HMP_ECOLI pepwindow swissprot:HMP_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HMP_ECOLI sigcleave swissprot:HMP_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HMP_ECOLI ## Database ID URL or Descriptions # AltName STHA_ECOLI NAD(P)(+) transhydrogenase [B-specific] # BioGrid 4263449 8 # CATALYTIC ACTIVITY STHA_ECOLI NADPH + NAD(+) = NADP(+) + NADH. # COFACTOR Name=FAD; Xref=ChEBI:CHEBI 57692; Note=Binds 1 FAD per subunit.; # EcoGene EG11428 sthA # FUNCTION STHA_ECOLI Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003957 NAD(P)+ transhydrogenase (B-specific) activity; IEA:UniProtKB-HAMAP. # GO_function GO:0008746 NAD(P)+ transhydrogenase activity; IDA:EcoCyc. # GO_function GO:0042802 identical protein binding; IDA:EcoCyc. # GO_function GO:0050660 flavin adenine dinucleotide binding; IDA:EcoCyc. # GO_process GO:0006739 NADP metabolic process; IEA:UniProtKB-HAMAP. # GO_process GO:0045454 cell redox homeostasis; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0042592 homeostatic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.30.390.30 -; 1. # Gene3D 3.50.50.60 -; 3. # HAMAP MF_00247 SthA # InterPro IPR004099 Pyr_nucl-diS_OxRdtase_dimer # InterPro IPR016156 FAD/NAD-linked_Rdtase_dimer # InterPro IPR022962 STH # InterPro IPR023753 FAD/NAD-binding_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00760 Nicotinate and nicotinamide metabolism # Organism STHA_ECOLI Escherichia coli (strain K12) # PATRIC 32123445 VBIEscCol129921_4083 # PIR E65203 E65203 # Pfam PF02852 Pyr_redox_dim # Pfam PF07992 Pyr_redox_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName STHA_ECOLI Soluble pyridine nucleotide transhydrogenase # RefSeq NP_418397 NC_000913.3 # RefSeq WP_001120810 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAC43068.1; Type=Frameshift; Positions=15; Evidence={ECO:0000305}; Sequence=CAA46822.1; Type=Frameshift; Positions=15; Evidence={ECO 0000305}; # SIMILARITY Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. {ECO 0000305}. # SUBCELLULAR LOCATION STHA_ECOLI Cytoplasm. # SUBUNIT STHA_ECOLI Homooligomer; probable homooctamer. # SUPFAM SSF51905 SSF51905 # SUPFAM SSF55424 SSF55424 # eggNOG COG1249 LUCA # eggNOG ENOG4105DX1 Bacteria BLAST swissprot:STHA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:STHA_ECOLI BioCyc ECOL316407:JW5551-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5551-MONOMER BioCyc EcoCyc:UDHA-MONOMER http://biocyc.org/getid?id=EcoCyc:UDHA-MONOMER BioCyc MetaCyc:UDHA-MONOMER http://biocyc.org/getid?id=MetaCyc:UDHA-MONOMER COG COG1249 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1249 DOI 10.1007/BF00332397 http://dx.doi.org/10.1007/BF00332397 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.6.1.1 http://www.genome.jp/dbget-bin/www_bget?EC:1.6.1.1 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X16531 http://www.ebi.ac.uk/ena/data/view/X16531 EMBL X66026 http://www.ebi.ac.uk/ena/data/view/X66026 ENZYME 1.6.1.1 http://enzyme.expasy.org/EC/1.6.1.1 EchoBASE EB1398 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1398 EcoGene EG11428 http://www.ecogene.org/geneInfo.php?eg_id=EG11428 EnsemblBacteria AAC76944 http://www.ensemblgenomes.org/id/AAC76944 EnsemblBacteria AAC76944 http://www.ensemblgenomes.org/id/AAC76944 EnsemblBacteria BAE77349 http://www.ensemblgenomes.org/id/BAE77349 EnsemblBacteria BAE77349 http://www.ensemblgenomes.org/id/BAE77349 EnsemblBacteria BAE77349 http://www.ensemblgenomes.org/id/BAE77349 EnsemblBacteria b3962 http://www.ensemblgenomes.org/id/b3962 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003957 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003957 GO_function GO:0008746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008746 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_process GO:0006739 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006739 GO_process GO:0045454 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045454 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.30.390.30 http://www.cathdb.info/version/latest/superfamily/3.30.390.30 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 GeneID 948461 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948461 HAMAP MF_00247 http://hamap.expasy.org/unirule/MF_00247 HOGENOM HOG000276708 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000276708&db=HOGENOM6 InParanoid P27306 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P27306 IntAct P27306 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P27306* IntEnz 1.6.1.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.6.1.1 InterPro IPR004099 http://www.ebi.ac.uk/interpro/entry/IPR004099 InterPro IPR016156 http://www.ebi.ac.uk/interpro/entry/IPR016156 InterPro IPR022962 http://www.ebi.ac.uk/interpro/entry/IPR022962 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5551 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5551 KEGG_Gene eco:b3962 http://www.genome.jp/dbget-bin/www_bget?eco:b3962 KEGG_Orthology KO:K00322 http://www.genome.jp/dbget-bin/www_bget?KO:K00322 KEGG_Pathway ko00760 http://www.genome.jp/kegg-bin/show_pathway?ko00760 KEGG_Reaction rn:R00112 http://www.genome.jp/dbget-bin/www_bget?rn:R00112 OMA ENEEFFF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ENEEFFF PSORT swissprot:STHA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:STHA_ECOLI PSORT-B swissprot:STHA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:STHA_ECOLI PSORT2 swissprot:STHA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:STHA_ECOLI Pfam PF02852 http://pfam.xfam.org/family/PF02852 Pfam PF07992 http://pfam.xfam.org/family/PF07992 Phobius swissprot:STHA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:STHA_ECOLI PhylomeDB P27306 http://phylomedb.org/?seqid=P27306 ProteinModelPortal P27306 http://www.proteinmodelportal.org/query/uniprot/P27306 PubMed 1447162 http://www.ncbi.nlm.nih.gov/pubmed/1447162 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2511419 http://www.ncbi.nlm.nih.gov/pubmed/2511419 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9922271 http://www.ncbi.nlm.nih.gov/pubmed/9922271 RefSeq NP_418397 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418397 RefSeq WP_001120810 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001120810 SMR P27306 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P27306 STRING 511145.b3962 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3962&targetmode=cogs STRING COG1249 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1249&targetmode=cogs SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 SUPFAM SSF55424 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55424 UniProtKB STHA_ECOLI http://www.uniprot.org/uniprot/STHA_ECOLI UniProtKB-AC P27306 http://www.uniprot.org/uniprot/P27306 charge swissprot:STHA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:STHA_ECOLI eggNOG COG1249 http://eggnogapi.embl.de/nog_data/html/tree/COG1249 eggNOG ENOG4105DX1 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DX1 epestfind swissprot:STHA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:STHA_ECOLI garnier swissprot:STHA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:STHA_ECOLI helixturnhelix swissprot:STHA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:STHA_ECOLI hmoment swissprot:STHA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:STHA_ECOLI iep swissprot:STHA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:STHA_ECOLI inforesidue swissprot:STHA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:STHA_ECOLI octanol swissprot:STHA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:STHA_ECOLI pepcoil swissprot:STHA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:STHA_ECOLI pepdigest swissprot:STHA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:STHA_ECOLI pepinfo swissprot:STHA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:STHA_ECOLI pepnet swissprot:STHA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:STHA_ECOLI pepstats swissprot:STHA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:STHA_ECOLI pepwheel swissprot:STHA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:STHA_ECOLI pepwindow swissprot:STHA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:STHA_ECOLI sigcleave swissprot:STHA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:STHA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260824 248 # EcoGene EG13320 ybiO # FUNCTION YBIO_ECOLI Mechanosensitive channel that protects cells against hypoosmotic stress when highly overexpressed. {ECO 0000269|PubMed 22874652}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006811 ion transport; IEA:UniProtKB-KW. # GO_process GO:0055085 transmembrane transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # INDUCTION Induced by NaCl and RpoS. {ECO:0000269|PubMed 22874652}. # InterPro IPR006685 MscS_channel # InterPro IPR010920 LSM_dom # InterPro IPR011014 MscS_channel_TM-2 # InterPro IPR011066 MscC_channel_C # Organism YBIO_ECOLI Escherichia coli (strain K12) # PATRIC 32116819 VBIEscCol129921_0835 # PIR H64817 H64817 # PROSITE PS01246 UPF0003 # Pfam PF00924 MS_channel # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBIO_ECOLI Moderate conductance mechanosensitive channel YbiO # RefSeq NP_415329 NC_000913.3 # RefSeq WP_001267253 NZ_LN832404.1 # SIMILARITY Belongs to the MscS (TC 1.A.23) family. {ECO 0000305}. # SUBCELLULAR LOCATION YBIO_ECOLI Cell inner membrane {ECO 0000269|PubMed 22874652}; Multi-pass membrane protein {ECO 0000269|PubMed 22874652}. # SUBUNIT Homoheptamer. {ECO:0000269|PubMed 22874652}. # SUPFAM SSF50182 SSF50182 # SUPFAM SSF82689 SSF82689 # SUPFAM SSF82861 SSF82861 # TCDB 1.A.23.3 the small conductance mechanosensitive ion channel (mscs) family # eggNOG COG0668 LUCA # eggNOG ENOG4105D8X Bacteria BLAST swissprot:YBIO_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBIO_ECOLI BioCyc ECOL316407:JW5108-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5108-MONOMER BioCyc EcoCyc:G6417-MONOMER http://biocyc.org/getid?id=EcoCyc:G6417-MONOMER DIP DIP-11435N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11435N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.4161/chan.20998 http://dx.doi.org/10.4161/chan.20998 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3104 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3104 EcoGene EG13320 http://www.ecogene.org/geneInfo.php?eg_id=EG13320 EnsemblBacteria AAC73895 http://www.ensemblgenomes.org/id/AAC73895 EnsemblBacteria AAC73895 http://www.ensemblgenomes.org/id/AAC73895 EnsemblBacteria BAA35474 http://www.ensemblgenomes.org/id/BAA35474 EnsemblBacteria BAA35474 http://www.ensemblgenomes.org/id/BAA35474 EnsemblBacteria BAA35474 http://www.ensemblgenomes.org/id/BAA35474 EnsemblBacteria b0808 http://www.ensemblgenomes.org/id/b0808 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006811 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006811 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 945935 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945935 HOGENOM HOG000118144 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000118144&db=HOGENOM6 InParanoid P75783 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P75783 InterPro IPR006685 http://www.ebi.ac.uk/interpro/entry/IPR006685 InterPro IPR010920 http://www.ebi.ac.uk/interpro/entry/IPR010920 InterPro IPR011014 http://www.ebi.ac.uk/interpro/entry/IPR011014 InterPro IPR011066 http://www.ebi.ac.uk/interpro/entry/IPR011066 KEGG_Gene ecj:JW5108 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5108 KEGG_Gene eco:b0808 http://www.genome.jp/dbget-bin/www_bget?eco:b0808 OMA LHNGAGE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LHNGAGE PROSITE PS01246 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01246 PSORT swissprot:YBIO_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBIO_ECOLI PSORT-B swissprot:YBIO_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBIO_ECOLI PSORT2 swissprot:YBIO_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBIO_ECOLI Pfam PF00924 http://pfam.xfam.org/family/PF00924 Phobius swissprot:YBIO_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBIO_ECOLI PhylomeDB P75783 http://phylomedb.org/?seqid=P75783 ProteinModelPortal P75783 http://www.proteinmodelportal.org/query/uniprot/P75783 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 22874652 http://www.ncbi.nlm.nih.gov/pubmed/22874652 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415329 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415329 RefSeq WP_001267253 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001267253 SMR P75783 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P75783 STRING 511145.b0808 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0808&targetmode=cogs SUPFAM SSF50182 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50182 SUPFAM SSF82689 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF82689 SUPFAM SSF82861 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF82861 TCDB 1.A.23.3 http://www.tcdb.org/search/result.php?tc=1.A.23.3 UniProtKB YBIO_ECOLI http://www.uniprot.org/uniprot/YBIO_ECOLI UniProtKB-AC P75783 http://www.uniprot.org/uniprot/P75783 charge swissprot:YBIO_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBIO_ECOLI eggNOG COG0668 http://eggnogapi.embl.de/nog_data/html/tree/COG0668 eggNOG ENOG4105D8X http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D8X epestfind swissprot:YBIO_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBIO_ECOLI garnier swissprot:YBIO_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBIO_ECOLI helixturnhelix swissprot:YBIO_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBIO_ECOLI hmoment swissprot:YBIO_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBIO_ECOLI iep swissprot:YBIO_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBIO_ECOLI inforesidue swissprot:YBIO_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBIO_ECOLI octanol swissprot:YBIO_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBIO_ECOLI pepcoil swissprot:YBIO_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBIO_ECOLI pepdigest swissprot:YBIO_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBIO_ECOLI pepinfo swissprot:YBIO_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBIO_ECOLI pepnet swissprot:YBIO_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBIO_ECOLI pepstats swissprot:YBIO_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBIO_ECOLI pepwheel swissprot:YBIO_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBIO_ECOLI pepwindow swissprot:YBIO_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBIO_ECOLI sigcleave swissprot:YBIO_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBIO_ECOLI ## Database ID URL or Descriptions # AltName PTPC1_ECOLI EIIC-Aga # AltName PTPC1_ECOLI PTS system N-acetylgalactosamine-specific EIIC component 1 # BioGrid 4262422 14 # DOMAIN PTPC1_ECOLI The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site. # EcoGene EG12770 agaC # FUNCTION PTPC1_ECOLI The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in N-acetylgalactosamine transport. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006810 transport # InterPro IPR004700 PTS_IIC_man # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00287 PTS system, galactosamine-specific II component # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko00052 Galactose metabolism # KEGG_Pathway ko02060 Phosphotransferase system (PTS) # Organism PTPC1_ECOLI Escherichia coli (strain K12) # PATRIC 32121696 VBIEscCol129921_3234 # PIR G65103 G65103 # PROSITE PS51106 PTS_EIIC_TYPE_4 # Pfam PF03609 EII-Sor # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PTPC1_ECOLI N-acetylgalactosamine permease IIC component 1 # RefSeq NP_417608 NC_000913.3 # RefSeq WP_000544489 NZ_LN832404.1 # SIMILARITY Contains 1 PTS EIIC type-4 domain. {ECO:0000255|PROSITE-ProRule PRU00429}. # SUBCELLULAR LOCATION PTPC1_ECOLI Cell inner membrane; Multi-pass membrane protein. # TIGRFAMs TIGR00822 EII-Sor # eggNOG COG3715 LUCA # eggNOG ENOG4105ETZ Bacteria BLAST swissprot:PTPC1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PTPC1_ECOLI BioCyc ECOL316407:JW3108-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3108-MONOMER BioCyc EcoCyc:AGAC-MONOMER http://biocyc.org/getid?id=EcoCyc:AGAC-MONOMER COG COG3715 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3715 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1099/13500872-142-2-231 http://dx.doi.org/10.1099/13500872-142-2-231 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2623 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2623 EcoGene EG12770 http://www.ecogene.org/geneInfo.php?eg_id=EG12770 EnsemblBacteria AAC76173 http://www.ensemblgenomes.org/id/AAC76173 EnsemblBacteria AAC76173 http://www.ensemblgenomes.org/id/AAC76173 EnsemblBacteria BAE77185 http://www.ensemblgenomes.org/id/BAE77185 EnsemblBacteria BAE77185 http://www.ensemblgenomes.org/id/BAE77185 EnsemblBacteria BAE77185 http://www.ensemblgenomes.org/id/BAE77185 EnsemblBacteria b3139 http://www.ensemblgenomes.org/id/b3139 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0009401 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009401 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GeneID 947652 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947652 HOGENOM HOG000097553 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000097553&db=HOGENOM6 InterPro IPR004700 http://www.ebi.ac.uk/interpro/entry/IPR004700 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3108 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3108 KEGG_Gene eco:b3139 http://www.genome.jp/dbget-bin/www_bget?eco:b3139 KEGG_Orthology KO:K10985 http://www.genome.jp/dbget-bin/www_bget?KO:K10985 KEGG_Pathway ko00052 http://www.genome.jp/kegg-bin/show_pathway?ko00052 KEGG_Pathway ko02060 http://www.genome.jp/kegg-bin/show_pathway?ko02060 KEGG_Reaction rn:R08367 http://www.genome.jp/dbget-bin/www_bget?rn:R08367 OMA MEITSAQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MEITSAQ PROSITE PS51106 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51106 PSORT swissprot:PTPC1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PTPC1_ECOLI PSORT-B swissprot:PTPC1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PTPC1_ECOLI PSORT2 swissprot:PTPC1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PTPC1_ECOLI Pfam PF03609 http://pfam.xfam.org/family/PF03609 Phobius swissprot:PTPC1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PTPC1_ECOLI PhylomeDB P42910 http://phylomedb.org/?seqid=P42910 ProteinModelPortal P42910 http://www.proteinmodelportal.org/query/uniprot/P42910 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8932697 http://www.ncbi.nlm.nih.gov/pubmed/8932697 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417608 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417608 RefSeq WP_000544489 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000544489 STRING 511145.b3139 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3139&targetmode=cogs STRING COG3715 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3715&targetmode=cogs TIGRFAMs TIGR00822 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00822 UniProtKB PTPC1_ECOLI http://www.uniprot.org/uniprot/PTPC1_ECOLI UniProtKB-AC P42910 http://www.uniprot.org/uniprot/P42910 charge swissprot:PTPC1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PTPC1_ECOLI eggNOG COG3715 http://eggnogapi.embl.de/nog_data/html/tree/COG3715 eggNOG ENOG4105ETZ http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105ETZ epestfind swissprot:PTPC1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PTPC1_ECOLI garnier swissprot:PTPC1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PTPC1_ECOLI helixturnhelix swissprot:PTPC1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PTPC1_ECOLI hmoment swissprot:PTPC1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PTPC1_ECOLI iep swissprot:PTPC1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PTPC1_ECOLI inforesidue swissprot:PTPC1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PTPC1_ECOLI octanol swissprot:PTPC1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PTPC1_ECOLI pepcoil swissprot:PTPC1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PTPC1_ECOLI pepdigest swissprot:PTPC1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PTPC1_ECOLI pepinfo swissprot:PTPC1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PTPC1_ECOLI pepnet swissprot:PTPC1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PTPC1_ECOLI pepstats swissprot:PTPC1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PTPC1_ECOLI pepwheel swissprot:PTPC1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PTPC1_ECOLI pepwindow swissprot:PTPC1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PTPC1_ECOLI sigcleave swissprot:PTPC1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PTPC1_ECOLI ## Database ID URL or Descriptions # BioGrid 4259522 156 # DISRUPTION PHENOTYPE The fliY-ydjN and yecS-ydjN double mutants are completely resistant to both L-selenaproline and L- selenocystine. {ECO:0000269|PubMed 25139244}. # ENZYME REGULATION Inhibited by L-cystine and L-cysteine, and to a lesser extent by D-cystine. {ECO:0000269|PubMed 25139244}. # EcoGene EG13990 ydjN # FUNCTION YDJN_ECOLI Involved in L-cystine transport. Can probably also transport L-cysteine. Mediates accumulation of the toxic compounds L-selenaproline (SCA) and L-selenocystine (SeCys). {ECO 0000269|PubMed 25139244}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0015184 L-cystine transmembrane transporter activity; IDA:EcoCyc. # GO_function GO:0015293 symporter activity; IEA:InterPro. # GO_function GO:0033229 cysteine transmembrane transporter activity; IDA:EcoCyc. # GO_process GO:0015811 L-cystine transport; IDA:EcoCyc. # GO_process GO:0042883 cysteine transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # Gene3D 1.10.3860.10 -; 1. # InterPro IPR001991 Na-dicarboxylate_symporter # Organism YDJN_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11958 PTHR11958 # PATRIC 32118765 VBIEscCol129921_1800 # PIR A64932 A64932 # PRINTS PR00173 EDTRNSPORT # Pfam PF00375 SDF # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName L-cystine transporter YdjN {ECO 0000305} # RefSeq NP_416243 NC_000913.3 # RefSeq WP_001010696 NZ_LN832404.1 # SIMILARITY Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. {ECO 0000305}. # SUBCELLULAR LOCATION YDJN_ECOLI Cell membrane {ECO 0000305}; Multi-pass membrane protein {ECO 0000255}. # SUPFAM SSF118215 SSF118215 # TCDB 2.A.23.1:the dicarboxylate/amino acid cation (na(+) or h(+)) symporter (daacs) family # eggNOG COG1823 LUCA # eggNOG ENOG4108ETY Bacteria BLAST swissprot:YDJN_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDJN_ECOLI BioCyc ECOL316407:JW1718-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1718-MONOMER BioCyc EcoCyc:G6934-MONOMER http://biocyc.org/getid?id=EcoCyc:G6934-MONOMER BioCyc MetaCyc:G6934-MONOMER http://biocyc.org/getid?id=MetaCyc:G6934-MONOMER COG COG1823 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1823 DIP DIP-11776N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11776N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1111/jam.12623 http://dx.doi.org/10.1111/jam.12623 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3746 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3746 EcoGene EG13990 http://www.ecogene.org/geneInfo.php?eg_id=EG13990 EnsemblBacteria AAC74799 http://www.ensemblgenomes.org/id/AAC74799 EnsemblBacteria AAC74799 http://www.ensemblgenomes.org/id/AAC74799 EnsemblBacteria BAA15509 http://www.ensemblgenomes.org/id/BAA15509 EnsemblBacteria BAA15509 http://www.ensemblgenomes.org/id/BAA15509 EnsemblBacteria BAA15509 http://www.ensemblgenomes.org/id/BAA15509 EnsemblBacteria b1729 http://www.ensemblgenomes.org/id/b1729 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015184 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015184 GO_function GO:0015293 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015293 GO_function GO:0033229 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033229 GO_process GO:0015811 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015811 GO_process GO:0042883 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042883 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 1.10.3860.10 http://www.cathdb.info/version/latest/superfamily/1.10.3860.10 GeneID 946238 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946238 HOGENOM HOG000208777 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000208777&db=HOGENOM6 InParanoid P77529 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77529 InterPro IPR001991 http://www.ebi.ac.uk/interpro/entry/IPR001991 KEGG_Gene ecj:JW1718 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1718 KEGG_Gene eco:b1729 http://www.genome.jp/dbget-bin/www_bget?eco:b1729 KEGG_Orthology KO:K06956 http://www.genome.jp/dbget-bin/www_bget?KO:K06956 OMA PITFIKK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PITFIKK PANTHER PTHR11958 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11958 PRINTS PR00173 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00173 PSORT swissprot:YDJN_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDJN_ECOLI PSORT-B swissprot:YDJN_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDJN_ECOLI PSORT2 swissprot:YDJN_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDJN_ECOLI Pfam PF00375 http://pfam.xfam.org/family/PF00375 Phobius swissprot:YDJN_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDJN_ECOLI PhylomeDB P77529 http://phylomedb.org/?seqid=P77529 ProteinModelPortal P77529 http://www.proteinmodelportal.org/query/uniprot/P77529 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 25139244 http://www.ncbi.nlm.nih.gov/pubmed/25139244 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416243 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416243 RefSeq WP_001010696 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001010696 STRING 511145.b1729 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1729&targetmode=cogs STRING COG1823 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1823&targetmode=cogs SUPFAM SSF118215 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF118215 TCDB 2.A.23.1 http://www.tcdb.org/search/result.php?tc=2.A.23.1 UniProtKB YDJN_ECOLI http://www.uniprot.org/uniprot/YDJN_ECOLI UniProtKB-AC P77529 http://www.uniprot.org/uniprot/P77529 charge swissprot:YDJN_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDJN_ECOLI eggNOG COG1823 http://eggnogapi.embl.de/nog_data/html/tree/COG1823 eggNOG ENOG4108ETY http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108ETY epestfind swissprot:YDJN_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDJN_ECOLI garnier swissprot:YDJN_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDJN_ECOLI helixturnhelix swissprot:YDJN_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDJN_ECOLI hmoment swissprot:YDJN_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDJN_ECOLI iep swissprot:YDJN_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDJN_ECOLI inforesidue swissprot:YDJN_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDJN_ECOLI octanol swissprot:YDJN_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDJN_ECOLI pepcoil swissprot:YDJN_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDJN_ECOLI pepdigest swissprot:YDJN_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDJN_ECOLI pepinfo swissprot:YDJN_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDJN_ECOLI pepnet swissprot:YDJN_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDJN_ECOLI pepstats swissprot:YDJN_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDJN_ECOLI pepwheel swissprot:YDJN_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDJN_ECOLI pepwindow swissprot:YDJN_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDJN_ECOLI sigcleave swissprot:YDJN_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDJN_ECOLI ## Database ID URL or Descriptions # BioGrid 4260549 11 # EcoGene EG14140 yfdR # GO_function GO:0008252 nucleotidase activity; IDA:EcoCyc. # GO_function GO:0050897 cobalt ion binding; IDA:EcoCyc. # GOslim_function GO:0016791 phosphatase activity # GOslim_function GO:0043167 ion binding # Gene3D 1.10.3210.10 -; 1. # IntAct P76514 4 # InterPro IPR006674 HD_domain # Organism YFDR_ECOLI Escherichia coli (strain K12) # PATRIC 32120099 VBIEscCol129921_2458 # PIR F65009 F65009 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFDR_ECOLI Uncharacterized protein YfdR # RefSeq NP_416862 NC_000913.3 # RefSeq WP_000008183 NZ_LN832404.1 # eggNOG COG1896 LUCA # eggNOG ENOG4108R7K Bacteria BLAST swissprot:YFDR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFDR_ECOLI BioCyc ECOL316407:JW2358-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2358-MONOMER BioCyc EcoCyc:G7230-MONOMER http://biocyc.org/getid?id=EcoCyc:G7230-MONOMER BioCyc MetaCyc:G7230-MONOMER http://biocyc.org/getid?id=MetaCyc:G7230-MONOMER COG COG3810 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3810 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3892 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3892 EcoGene EG14140 http://www.ecogene.org/geneInfo.php?eg_id=EG14140 EnsemblBacteria AAC75420 http://www.ensemblgenomes.org/id/AAC75420 EnsemblBacteria AAC75420 http://www.ensemblgenomes.org/id/AAC75420 EnsemblBacteria BAE76700 http://www.ensemblgenomes.org/id/BAE76700 EnsemblBacteria BAE76700 http://www.ensemblgenomes.org/id/BAE76700 EnsemblBacteria BAE76700 http://www.ensemblgenomes.org/id/BAE76700 EnsemblBacteria b2361 http://www.ensemblgenomes.org/id/b2361 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008252 GO_function GO:0050897 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050897 GOslim_function GO:0016791 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016791 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 1.10.3210.10 http://www.cathdb.info/version/latest/superfamily/1.10.3210.10 GeneID 946834 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946834 HOGENOM HOG000006145 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000006145&db=HOGENOM6 InParanoid P76514 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76514 IntAct P76514 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P76514* InterPro IPR006674 http://www.ebi.ac.uk/interpro/entry/IPR006674 KEGG_Gene ecj:JW2358 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2358 KEGG_Gene eco:b2361 http://www.genome.jp/dbget-bin/www_bget?eco:b2361 KEGG_Orthology KO:K06952 http://www.genome.jp/dbget-bin/www_bget?KO:K06952 OMA QHSVHVS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QHSVHVS PSORT swissprot:YFDR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFDR_ECOLI PSORT-B swissprot:YFDR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFDR_ECOLI PSORT2 swissprot:YFDR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFDR_ECOLI Phobius swissprot:YFDR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFDR_ECOLI ProteinModelPortal P76514 http://www.proteinmodelportal.org/query/uniprot/P76514 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416862 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416862 RefSeq WP_000008183 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000008183 STRING 511145.b2361 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2361&targetmode=cogs STRING COG3810 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3810&targetmode=cogs UniProtKB YFDR_ECOLI http://www.uniprot.org/uniprot/YFDR_ECOLI UniProtKB-AC P76514 http://www.uniprot.org/uniprot/P76514 charge swissprot:YFDR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFDR_ECOLI eggNOG COG1896 http://eggnogapi.embl.de/nog_data/html/tree/COG1896 eggNOG ENOG4108R7K http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108R7K epestfind swissprot:YFDR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFDR_ECOLI garnier swissprot:YFDR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFDR_ECOLI helixturnhelix swissprot:YFDR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFDR_ECOLI hmoment swissprot:YFDR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFDR_ECOLI iep swissprot:YFDR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFDR_ECOLI inforesidue swissprot:YFDR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFDR_ECOLI octanol swissprot:YFDR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFDR_ECOLI pepcoil swissprot:YFDR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFDR_ECOLI pepdigest swissprot:YFDR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFDR_ECOLI pepinfo swissprot:YFDR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFDR_ECOLI pepnet swissprot:YFDR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFDR_ECOLI pepstats swissprot:YFDR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFDR_ECOLI pepwheel swissprot:YFDR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFDR_ECOLI pepwindow swissprot:YFDR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFDR_ECOLI sigcleave swissprot:YFDR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFDR_ECOLI ## Database ID URL or Descriptions # AltName CBRA_ECOLI CreB-regulated gene A protein # BioGrid 4261311 15 # EcoGene EG11714 cbrA # GO_function GO:0016491 oxidoreductase activity; IEA:InterPro. # GO_function GO:0050660 flavin adenine dinucleotide binding; IDA:EcoCyc. # GO_function GO:0071949 FAD binding; IEA:InterPro. # GO_process GO:0030153 bacteriocin immunity; IMP:EcoCyc. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0019748 secondary metabolic process # Gene3D 3.50.50.60 -; 2. # INDUCTION CBRA_ECOLI Induced by the two-component regulatory system CreC/CreB and by the signal autoinducer AI-2. {ECO 0000269|PubMed 11350954, ECO 0000269|PubMed 11514505}. # InterPro IPR002938 FAD-bd # InterPro IPR023753 FAD/NAD-binding_dom # MISCELLANEOUS CBRA_ECOLI Disruption of this gene leads to greater resistance to hydroxylamine and hypersensitivity to ofloxacin, 5,7-dichloro- 8-hydroxyquinaldine (a lipophilic chelator) and 18-crown-6 ether (an ionophore). # Organism CBRA_ECOLI Escherichia coli (strain K12) # PATRIC 32122875 VBIEscCol129921_3813 # PIR C65171 C65171 # Pfam PF01494 FAD_binding_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CBRA_ECOLI Protein CbrA # RefSeq NP_418145 NC_000913.3 # RefSeq WP_001340434 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA62042.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the CbrA family. {ECO 0000305}. # SUPFAM SSF51905 SSF51905; 2 # eggNOG COG0644 LUCA # eggNOG ENOG4107WAP Bacteria BLAST swissprot:CBRA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CBRA_ECOLI BioCyc ECOL316407:JW5631-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5631-MONOMER BioCyc EcoCyc:EG11714-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11714-MONOMER DIP DIP-12455N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12455N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M011186200 http://dx.doi.org/10.1074/jbc.M011186200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.183.18.5239-5247.2001 http://dx.doi.org/10.1128/JB.183.18.5239-5247.2001 DOI 10.1128/JB.185.16.4956-4972.2003 http://dx.doi.org/10.1128/JB.185.16.4956-4972.2003 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1665 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1665 EcoGene EG11714 http://www.ecogene.org/geneInfo.php?eg_id=EG11714 EnsemblBacteria AAC76713 http://www.ensemblgenomes.org/id/AAC76713 EnsemblBacteria AAC76713 http://www.ensemblgenomes.org/id/AAC76713 EnsemblBacteria BAE77604 http://www.ensemblgenomes.org/id/BAE77604 EnsemblBacteria BAE77604 http://www.ensemblgenomes.org/id/BAE77604 EnsemblBacteria BAE77604 http://www.ensemblgenomes.org/id/BAE77604 EnsemblBacteria b3690 http://www.ensemblgenomes.org/id/b3690 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GO_function GO:0050660 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050660 GO_function GO:0071949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071949 GO_process GO:0030153 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030153 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0019748 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019748 Gene3D 3.50.50.60 http://www.cathdb.info/version/latest/superfamily/3.50.50.60 GeneID 948197 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948197 HOGENOM HOG000277521 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000277521&db=HOGENOM6 InParanoid P31456 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31456 IntAct P31456 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31456* InterPro IPR002938 http://www.ebi.ac.uk/interpro/entry/IPR002938 InterPro IPR023753 http://www.ebi.ac.uk/interpro/entry/IPR023753 KEGG_Gene ecj:JW5631 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5631 KEGG_Gene eco:b3690 http://www.genome.jp/dbget-bin/www_bget?eco:b3690 OMA SEKMEHF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SEKMEHF PSORT swissprot:CBRA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CBRA_ECOLI PSORT-B swissprot:CBRA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CBRA_ECOLI PSORT2 swissprot:CBRA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CBRA_ECOLI Pfam PF01494 http://pfam.xfam.org/family/PF01494 Phobius swissprot:CBRA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CBRA_ECOLI PhylomeDB P31456 http://phylomedb.org/?seqid=P31456 ProteinModelPortal P31456 http://www.proteinmodelportal.org/query/uniprot/P31456 PubMed 11350954 http://www.ncbi.nlm.nih.gov/pubmed/11350954 PubMed 11514505 http://www.ncbi.nlm.nih.gov/pubmed/11514505 PubMed 12897016 http://www.ncbi.nlm.nih.gov/pubmed/12897016 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418145 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418145 RefSeq WP_001340434 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001340434 STRING 511145.b3690 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3690&targetmode=cogs SUPFAM SSF51905 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51905 UniProtKB CBRA_ECOLI http://www.uniprot.org/uniprot/CBRA_ECOLI UniProtKB-AC P31456 http://www.uniprot.org/uniprot/P31456 charge swissprot:CBRA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CBRA_ECOLI eggNOG COG0644 http://eggnogapi.embl.de/nog_data/html/tree/COG0644 eggNOG ENOG4107WAP http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107WAP epestfind swissprot:CBRA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CBRA_ECOLI garnier swissprot:CBRA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CBRA_ECOLI helixturnhelix swissprot:CBRA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CBRA_ECOLI hmoment swissprot:CBRA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CBRA_ECOLI iep swissprot:CBRA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CBRA_ECOLI inforesidue swissprot:CBRA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CBRA_ECOLI octanol swissprot:CBRA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CBRA_ECOLI pepcoil swissprot:CBRA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CBRA_ECOLI pepdigest swissprot:CBRA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CBRA_ECOLI pepinfo swissprot:CBRA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CBRA_ECOLI pepnet swissprot:CBRA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CBRA_ECOLI pepstats swissprot:CBRA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CBRA_ECOLI pepwheel swissprot:CBRA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CBRA_ECOLI pepwindow swissprot:CBRA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CBRA_ECOLI sigcleave swissprot:CBRA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CBRA_ECOLI ## Database ID URL or Descriptions # AltName 5-(carboxyamino)imidazole ribonucleotide mutase {ECO:0000255|HAMAP-Rule MF_01929, ECO:0000305} # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=140 uM for N5-CAIR {ECO 0000269|PubMed:8117684}; # BRENDA 5.4.99.18 2026 # BioGrid 4261243 17 # CATALYTIC ACTIVITY PURE_ECOLI 5-carboxyamino-1-(5-phospho-D- ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxylate. {ECO 0000255|HAMAP-Rule MF_01929, ECO 0000269|PubMed 10074353, ECO 0000269|PubMed 8117684}. # CAUTION Was originally thought to be the catalytic subunit of phosphoribosylaminoimidazole carboxylase, with ATPase subunit PurK. {ECO:0000305|PubMed 2464576}. # EcoGene EG10793 purE # FUNCTION PURE_ECOLI Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). {ECO 0000255|HAMAP-Rule MF_01929, ECO 0000269|PubMed 8117684}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0034023 5-(carboxyamino)imidazole ribonucleotide mutase activity; IDA:EcoCyc. # GO_process GO:0006189 'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.7700 -; 1. # HAMAP MF_01929 PurE_classI # IntAct P0AG18 11 # InterPro IPR000031 PurE_dom # InterPro IPR024694 PurE_prokaryotes # InterPro IPR033747 PurE_ClassI # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00230 Purine metabolism # Organism PURE_ECOLI Escherichia coli (strain K12) # PATHWAY PURE_ECOLI Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5- amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route) step 2/2. {ECO 0000255|HAMAP-Rule MF_01929, ECO 0000269|PubMed 8117684}. # PATRIC 32116206 VBIEscCol129921_0544 # PDB 1D7A X-ray; 2.50 A; A/B/C/D/L/M/N/O=8-167 # PDB 1QCZ X-ray; 1.50 A; A=1-169 # PDB 2ATE X-ray; 1.80 A; A=1-169 # PDB 2NSH X-ray; 1.80 A; A=1-169 # PDB 2NSJ X-ray; 2.31 A; A=1-169 # PDB 2NSL X-ray; 2.00 A; A=1-169 # PIR JT0499 DEECPE # PIRSF PIRSF001338 AIR_carboxylase # Pfam PF00731 AIRC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName N5-carboxyaminoimidazole ribonucleotide mutase {ECO:0000255|HAMAP-Rule MF_01929, ECO:0000305} # RefSeq NP_415056 NC_000913.3 # RefSeq WP_001295318 NZ_LN832404.1 # SIMILARITY Belongs to the AIR carboxylase family. Class I subfamily. {ECO:0000255|HAMAP-Rule MF_01929, ECO:0000305}. # SMART SM01001 AIRC # SUBUNIT Homooctamer. {ECO:0000269|PubMed 10574791}. # SUPFAM SSF52255 SSF52255 # TIGRFAMs TIGR01162 purE # UniPathway UPA00074 UER00943 # eggNOG COG0041 LUCA # eggNOG ENOG4108UM6 Bacteria BLAST swissprot:PURE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PURE_ECOLI BioCyc ECOL316407:JW0512-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0512-MONOMER BioCyc EcoCyc:PURE-MONOMER http://biocyc.org/getid?id=EcoCyc:PURE-MONOMER BioCyc MetaCyc:PURE-MONOMER http://biocyc.org/getid?id=MetaCyc:PURE-MONOMER COG COG0041 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0041 DIP DIP-10610N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10610N DOI 10.1016/S0969-2126(00)80029-5 http://dx.doi.org/10.1016/S0969-2126(00)80029-5 DOI 10.1021/bi00136a016 http://dx.doi.org/10.1021/bi00136a016 DOI 10.1021/bi00174a038 http://dx.doi.org/10.1021/bi00174a038 DOI 10.1021/bi9827159 http://dx.doi.org/10.1021/bi9827159 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.4.99.18 {ECO:0000255|HAMAP-Rule:MF_01929, ECO:0000269|PubMed:10074353, ECO:0000269|PubMed:8117684} http://www.genome.jp/dbget-bin/www_bget?EC:5.4.99.18 {ECO:0000255|HAMAP-Rule:MF_01929, ECO:0000269|PubMed:10074353, ECO:0000269|PubMed:8117684} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M19657 http://www.ebi.ac.uk/ena/data/view/M19657 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82664 http://www.ebi.ac.uk/ena/data/view/U82664 EMBL X12982 http://www.ebi.ac.uk/ena/data/view/X12982 ENZYME 5.4.99.18 {ECO:0000255|HAMAP-Rule:MF_01929, ECO:0000269|PubMed:10074353, ECO:0000269|PubMed:8117684} http://enzyme.expasy.org/EC/5.4.99.18 {ECO:0000255|HAMAP-Rule:MF_01929, ECO:0000269|PubMed:10074353, ECO:0000269|PubMed:8117684} EchoBASE EB0786 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0786 EcoGene EG10793 http://www.ecogene.org/geneInfo.php?eg_id=EG10793 EnsemblBacteria AAC73625 http://www.ensemblgenomes.org/id/AAC73625 EnsemblBacteria AAC73625 http://www.ensemblgenomes.org/id/AAC73625 EnsemblBacteria BAE76300 http://www.ensemblgenomes.org/id/BAE76300 EnsemblBacteria BAE76300 http://www.ensemblgenomes.org/id/BAE76300 EnsemblBacteria BAE76300 http://www.ensemblgenomes.org/id/BAE76300 EnsemblBacteria b0523 http://www.ensemblgenomes.org/id/b0523 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0034023 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034023 GO_process GO:0006189 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006189 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.7700 http://www.cathdb.info/version/latest/superfamily/3.40.50.7700 GeneID 949031 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949031 HAMAP MF_01929 http://hamap.expasy.org/unirule/MF_01929 HOGENOM HOG000034140 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000034140&db=HOGENOM6 InParanoid P0AG18 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AG18 IntAct P0AG18 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AG18* IntEnz 5.4.99.18 {ECO:0000255|HAMAP-Rule:MF_01929, ECO:0000269|PubMed:10074353, ECO:0000269|PubMed:8117684} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.4.99.18 {ECO:0000255|HAMAP-Rule:MF_01929, ECO:0000269|PubMed:10074353, ECO:0000269|PubMed:8117684} InterPro IPR000031 http://www.ebi.ac.uk/interpro/entry/IPR000031 InterPro IPR024694 http://www.ebi.ac.uk/interpro/entry/IPR024694 InterPro IPR033747 http://www.ebi.ac.uk/interpro/entry/IPR033747 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0512 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0512 KEGG_Gene eco:b0523 http://www.genome.jp/dbget-bin/www_bget?eco:b0523 KEGG_Orthology KO:K01588 http://www.genome.jp/dbget-bin/www_bget?KO:K01588 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Reaction rn:R07405 http://www.genome.jp/dbget-bin/www_bget?rn:R07405 OMA SDWATMR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SDWATMR PDB 1D7A http://www.ebi.ac.uk/pdbe-srv/view/entry/1D7A PDB 1QCZ http://www.ebi.ac.uk/pdbe-srv/view/entry/1QCZ PDB 2ATE http://www.ebi.ac.uk/pdbe-srv/view/entry/2ATE PDB 2NSH http://www.ebi.ac.uk/pdbe-srv/view/entry/2NSH PDB 2NSJ http://www.ebi.ac.uk/pdbe-srv/view/entry/2NSJ PDB 2NSL http://www.ebi.ac.uk/pdbe-srv/view/entry/2NSL PDBsum 1D7A http://www.ebi.ac.uk/pdbsum/1D7A PDBsum 1QCZ http://www.ebi.ac.uk/pdbsum/1QCZ PDBsum 2ATE http://www.ebi.ac.uk/pdbsum/2ATE PDBsum 2NSH http://www.ebi.ac.uk/pdbsum/2NSH PDBsum 2NSJ http://www.ebi.ac.uk/pdbsum/2NSJ PDBsum 2NSL http://www.ebi.ac.uk/pdbsum/2NSL PSORT swissprot:PURE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PURE_ECOLI PSORT-B swissprot:PURE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PURE_ECOLI PSORT2 swissprot:PURE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PURE_ECOLI Pfam PF00731 http://pfam.xfam.org/family/PF00731 Phobius swissprot:PURE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PURE_ECOLI PhylomeDB P0AG18 http://phylomedb.org/?seqid=P0AG18 ProteinModelPortal P0AG18 http://www.proteinmodelportal.org/query/uniprot/P0AG18 PubMed 10074353 http://www.ncbi.nlm.nih.gov/pubmed/10074353 PubMed 10574791 http://www.ncbi.nlm.nih.gov/pubmed/10574791 PubMed 1534690 http://www.ncbi.nlm.nih.gov/pubmed/1534690 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2464576 http://www.ncbi.nlm.nih.gov/pubmed/2464576 PubMed 2644189 http://www.ncbi.nlm.nih.gov/pubmed/2644189 PubMed 8117684 http://www.ncbi.nlm.nih.gov/pubmed/8117684 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415056 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415056 RefSeq WP_001295318 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001295318 SMART SM01001 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM01001 SMR P0AG18 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AG18 STRING 511145.b0523 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0523&targetmode=cogs STRING COG0041 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0041&targetmode=cogs SUPFAM SSF52255 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52255 SWISS-2DPAGE P0AG18 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AG18 TIGRFAMs TIGR01162 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01162 UniProtKB PURE_ECOLI http://www.uniprot.org/uniprot/PURE_ECOLI UniProtKB-AC P0AG18 http://www.uniprot.org/uniprot/P0AG18 charge swissprot:PURE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PURE_ECOLI eggNOG COG0041 http://eggnogapi.embl.de/nog_data/html/tree/COG0041 eggNOG ENOG4108UM6 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108UM6 epestfind swissprot:PURE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PURE_ECOLI garnier swissprot:PURE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PURE_ECOLI helixturnhelix swissprot:PURE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PURE_ECOLI hmoment swissprot:PURE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PURE_ECOLI iep swissprot:PURE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PURE_ECOLI inforesidue swissprot:PURE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PURE_ECOLI octanol swissprot:PURE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PURE_ECOLI pepcoil swissprot:PURE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PURE_ECOLI pepdigest swissprot:PURE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PURE_ECOLI pepinfo swissprot:PURE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PURE_ECOLI pepnet swissprot:PURE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PURE_ECOLI pepstats swissprot:PURE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PURE_ECOLI pepwheel swissprot:PURE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PURE_ECOLI pepwindow swissprot:PURE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PURE_ECOLI sigcleave swissprot:PURE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PURE_ECOLI ## Database ID URL or Descriptions # BioGrid 4262222 14 # EcoGene EG12064 napG # FUNCTION NAPG_ECOLI Involved in electron transfer. {ECO 0000305}. # GO_component GO:0005886 plasma membrane; IBA:GO_Central. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GO_process GO:0055114 oxidation-reduction process; IEA:UniProtKB-KW. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # IntAct P0AAL3 4 # InterPro IPR004494 MauM_NapG # InterPro IPR006311 TAT_signal # InterPro IPR017896 4Fe4S_Fe-S-bd # InterPro IPR017900 4Fe4S_Fe_S_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Pathway ko00910 Nitrogen metabolism # Organism NAPG_ECOLI Escherichia coli (strain K12) # PATRIC 32119769 VBIEscCol129921_2294 # PIR C64990 C64990 # PROSITE PS00198 4FE4S_FER_1 # PROSITE PS51318 TAT # PROSITE PS51379 4FE4S_FER_2; 4 # PTM NAPG_ECOLI Exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven. # Pfam PF12800 Fer4_4; 2 # Pfam PF12838 Fer4_7 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName NAPG_ECOLI Ferredoxin-type protein NapG # RefSeq NP_416709 NC_000913.3 # RefSeq WP_000091291 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA16397.1; Type=Frameshift; Positions=145; Evidence={ECO:0000305}; Sequence=AAA16398.1; Type=Frameshift; Positions=145; Evidence={ECO 0000305}; # SIMILARITY Contains 4 4Fe-4S ferredoxin-type domains. {ECO:0000255|PROSITE-ProRule PRU00711}. # TIGRFAMs TIGR00397 mauM_napG # eggNOG COG1145 LUCA # eggNOG ENOG4108BGM Bacteria BLAST swissprot:NAPG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NAPG_ECOLI BioCyc ECOL316407:JW2193-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2193-MONOMER BioCyc EcoCyc:NAPG-MONOMER http://biocyc.org/getid?id=EcoCyc:NAPG-MONOMER BioCyc MetaCyc:NAPG-MONOMER http://biocyc.org/getid?id=MetaCyc:NAPG-MONOMER COG COG1145 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1145 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M610507200 http://dx.doi.org/10.1074/jbc.M610507200 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00008 http://www.ebi.ac.uk/ena/data/view/U00008 EMBL U00008 http://www.ebi.ac.uk/ena/data/view/U00008 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1993 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1993 EcoGene EG12064 http://www.ecogene.org/geneInfo.php?eg_id=EG12064 EnsemblBacteria AAC75265 http://www.ensemblgenomes.org/id/AAC75265 EnsemblBacteria AAC75265 http://www.ensemblgenomes.org/id/AAC75265 EnsemblBacteria BAE76668 http://www.ensemblgenomes.org/id/BAE76668 EnsemblBacteria BAE76668 http://www.ensemblgenomes.org/id/BAE76668 EnsemblBacteria BAE76668 http://www.ensemblgenomes.org/id/BAE76668 EnsemblBacteria b2205 http://www.ensemblgenomes.org/id/b2205 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0055114 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GeneID 945544 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945544 HOGENOM HOG000275499 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000275499&db=HOGENOM6 InParanoid P0AAL3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AAL3 IntAct P0AAL3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AAL3* InterPro IPR004494 http://www.ebi.ac.uk/interpro/entry/IPR004494 InterPro IPR006311 http://www.ebi.ac.uk/interpro/entry/IPR006311 InterPro IPR017896 http://www.ebi.ac.uk/interpro/entry/IPR017896 InterPro IPR017900 http://www.ebi.ac.uk/interpro/entry/IPR017900 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Gene ecj:JW2193 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2193 KEGG_Gene eco:b2205 http://www.genome.jp/dbget-bin/www_bget?eco:b2205 KEGG_Orthology KO:K02573 http://www.genome.jp/dbget-bin/www_bget?KO:K02573 KEGG_Pathway ko00910 http://www.genome.jp/kegg-bin/show_pathway?ko00910 KEGG_Reaction rn:R00798 http://www.genome.jp/dbget-bin/www_bget?rn:R00798 OMA LIDHETC http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LIDHETC PROSITE PS00198 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00198 PROSITE PS51318 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51318 PROSITE PS51379 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51379 PSORT swissprot:NAPG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NAPG_ECOLI PSORT-B swissprot:NAPG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NAPG_ECOLI PSORT2 swissprot:NAPG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NAPG_ECOLI Pfam PF12800 http://pfam.xfam.org/family/PF12800 Pfam PF12838 http://pfam.xfam.org/family/PF12838 Phobius swissprot:NAPG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NAPG_ECOLI PhylomeDB P0AAL3 http://phylomedb.org/?seqid=P0AAL3 ProteinModelPortal P0AAL3 http://www.proteinmodelportal.org/query/uniprot/P0AAL3 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17218314 http://www.ncbi.nlm.nih.gov/pubmed/17218314 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416709 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416709 RefSeq WP_000091291 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000091291 SMR P0AAL3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AAL3 STRING 511145.b2205 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2205&targetmode=cogs STRING COG1145 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1145&targetmode=cogs TIGRFAMs TIGR00397 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00397 UniProtKB NAPG_ECOLI http://www.uniprot.org/uniprot/NAPG_ECOLI UniProtKB-AC P0AAL3 http://www.uniprot.org/uniprot/P0AAL3 charge swissprot:NAPG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NAPG_ECOLI eggNOG COG1145 http://eggnogapi.embl.de/nog_data/html/tree/COG1145 eggNOG ENOG4108BGM http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108BGM epestfind swissprot:NAPG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NAPG_ECOLI garnier swissprot:NAPG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NAPG_ECOLI helixturnhelix swissprot:NAPG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NAPG_ECOLI hmoment swissprot:NAPG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NAPG_ECOLI iep swissprot:NAPG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NAPG_ECOLI inforesidue swissprot:NAPG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NAPG_ECOLI octanol swissprot:NAPG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NAPG_ECOLI pepcoil swissprot:NAPG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NAPG_ECOLI pepdigest swissprot:NAPG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NAPG_ECOLI pepinfo swissprot:NAPG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NAPG_ECOLI pepnet swissprot:NAPG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NAPG_ECOLI pepstats swissprot:NAPG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NAPG_ECOLI pepwheel swissprot:NAPG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NAPG_ECOLI pepwindow swissprot:NAPG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NAPG_ECOLI sigcleave swissprot:NAPG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NAPG_ECOLI ## Database ID URL or Descriptions # AltName L-threonylcarbamoyladenylate synthase {ECO:0000255|HAMAP-Rule MF_01852} # AltName TSAC_ECOLI Ribosome maturation factor TsaC # AltName t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaC {ECO:0000255|HAMAP-Rule MF_01852} # AltName tRNA threonylcarbamoyladenosine biosynthesis protein TsaC {ECO:0000255|HAMAP-Rule MF_01852} # BIOPHYSICOCHEMICAL PROPERTIES TSAC_ECOLI Kinetic parameters KM=93 uM for ATP {ECO 0000269|PubMed 23072323}; KM=0.68 uM for L-threonylcarbamoyl-AMP {ECO 0000269|PubMed 23072323}; Note=kcat is 0.10 sec(-1) for ATP-dependent TC-AMP formation and 20 sec(-1) for the reverse reaction.; # BRENDA 2.7.7.87 2026 # BioGrid 4262454 209 # CATALYTIC ACTIVITY TSAC_ECOLI L-threonine + ATP + HCO(3)(-) = L- threonylcarbamoyladenylate + diphosphate + H(2)O. {ECO 0000255|HAMAP-Rule MF_01852, ECO 0000269|PubMed 23072323}. # CAUTION TSAC_ECOLI Was also proposed to catalyze the transfer of the threonylcarbamoyl moiety of TC-AMP to the N6 group of A37 (PubMed 21285948 and PubMed 21775474). However, it was shown that this reaction is catalyzed in B.subtilis by the TsaEBD proteins (PubMed 23072323). {ECO 0000305|PubMed 23072323}. # CAUTION The well-known t(6)A modification appears to be a hydrolyzed artifact of natural cyclic t(6)A (ct(6)A) that occurs during the preparation and handling of tRNA in E.coli and many other species (PubMed:23242255). In these species, the t(6)A modification is processed further by dehydration into ct(6)A, a reaction catalyzed by TcdA. {ECO 0000305}. # DISRUPTION PHENOTYPE The knockdown of this gene results in a loss of t(6)A37 modification in tRNAs. {ECO:0000269|PubMed 19287007}. # EcoGene EG12840 tsaC # FUNCTION TSAC_ECOLI Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Is also able to catalyze the reverse reaction in vitro, i.e. the formation of ATP from TC-AMP and PPi. Shows higher affinity for the full-length tRNA(Thr) lacking only the t(6)A37 modification than for its fully modified counterpart. Could also be required for the maturation of 16S rRNA. Binds to double-stranded RNA but does not interact tightly with either of the ribosomal subunits, or the 70S particles. {ECO 0000255|HAMAP-Rule MF_01852, ECO 0000269|PubMed 15716138, ECO 0000269|PubMed 19287007, ECO 0000269|PubMed 21285948, ECO 0000269|PubMed 22378793, ECO 0000269|PubMed 23072323}. # GO_component GO:0005737 cytoplasm; IDA:EcoCyc. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000049 tRNA binding; IDA:EcoCyc. # GO_function GO:0003725 double-stranded RNA binding; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IDA:EcoCyc. # GO_function GO:0016779 nucleotidyltransferase activity; IDA:UniProtKB. # GO_function GO:0061710 L-threonylcarbamoyladenylate synthase; IDA:EcoCyc. # GO_process GO:0002949 tRNA threonylcarbamoyladenosine modification; IDA:EcoCyc. # GO_process GO:0006364 rRNA processing; IEA:UniProtKB-KW. # GO_process GO:0006450 regulation of translational fidelity; IBA:GO_Central. # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006399 tRNA metabolic process # GOslim_process GO:0008150 biological_process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.90.870.10 -; 1. # HAMAP MF_01852 TsaC # IntAct P45748 12 # InterPro IPR006070 YrdC-like_dom # InterPro IPR017945 DHBP_synth_RibB-like_a/b_dom # InterPro IPR023535 TC-AMP_synthase # KEGG_Brite ko03009 Ribosome biogenesis # KEGG_Brite ko03016 Transfer RNA biogenesis # MISCELLANEOUS TsaBCDE are necessary and sufficient for tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification in vitro in E.coli. {ECO:0000305|PubMed 22378793}. # MISCELLANEOUS Unlike previously thought, the formation of TC-AMP does not proceed via an ATP-activated HCO(3)(-) intermediate such as carboxy-AMP. {ECO:0000305|PubMed 23072323}. # Organism TSAC_ECOLI Escherichia coli (strain K12) # PATRIC 32121998 VBIEscCol129921_3376 # PDB 1HRU X-ray; 2.00 A; A/B=1-188 # PDB 2MX1 NMR; -; A=2-190 # PIR E65120 E65120 # PROSITE PS51163 YRDC # Pfam PF01300 Sua5_yciO_yrdC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Threonylcarbamoyl-AMP synthase {ECO:0000255|HAMAP-Rule MF_01852} # RefSeq NP_417741 NC_000913.3 # RefSeq WP_001301412 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA58079.1; Type=Frameshift; Positions=19; Evidence={ECO 0000305}; # SIMILARITY Belongs to the SUA5 family. TsaC subfamily. {ECO:0000255|HAMAP-Rule MF_01852}. # SIMILARITY Contains 1 YrdC-like domain. {ECO:0000255|HAMAP- Rule MF_01852}. # SUBCELLULAR LOCATION TSAC_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_01852}. # SUBUNIT Interacts with TsaB and TsaD. {ECO:0000269|PubMed 22378793}. # SUPFAM SSF55821 SSF55821 # eggNOG COG0009 LUCA # eggNOG ENOG4105EK0 Bacteria BLAST swissprot:TSAC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TSAC_ECOLI BioCyc ECOL316407:JW3243-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3243-MONOMER BioCyc EcoCyc:G7698-MONOMER http://biocyc.org/getid?id=EcoCyc:G7698-MONOMER BioCyc MetaCyc:G7698-MONOMER http://biocyc.org/getid?id=MetaCyc:G7698-MONOMER COG COG0009 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0009 DIP DIP-12916N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12916N DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1016/j.bbaexp.2004.11.010 http://dx.doi.org/10.1016/j.bbaexp.2004.11.010 DOI 10.1021/bi301233d http://dx.doi.org/10.1021/bi301233d DOI 10.1038/emboj.2010.363 http://dx.doi.org/10.1038/emboj.2010.363 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M112.344028 http://dx.doi.org/10.1074/jbc.M112.344028 DOI 10.1093/nar/gkp152 http://dx.doi.org/10.1093/nar/gkp152 DOI 10.1110/ps.9.12.2557 http://dx.doi.org/10.1110/ps.9.12.2557 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1261/rna.2592411 http://dx.doi.org/10.1261/rna.2592411 EC_number EC:2.7.7.87 {ECO:0000255|HAMAP-Rule:MF_01852} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.87 {ECO:0000255|HAMAP-Rule:MF_01852} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 2.7.7.87 {ECO:0000255|HAMAP-Rule:MF_01852} http://enzyme.expasy.org/EC/2.7.7.87 {ECO:0000255|HAMAP-Rule:MF_01852} EchoBASE EB2689 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2689 EcoGene EG12840 http://www.ecogene.org/geneInfo.php?eg_id=EG12840 EnsemblBacteria AAC76307 http://www.ensemblgenomes.org/id/AAC76307 EnsemblBacteria AAC76307 http://www.ensemblgenomes.org/id/AAC76307 EnsemblBacteria BAE78009 http://www.ensemblgenomes.org/id/BAE78009 EnsemblBacteria BAE78009 http://www.ensemblgenomes.org/id/BAE78009 EnsemblBacteria BAE78009 http://www.ensemblgenomes.org/id/BAE78009 EnsemblBacteria b3282 http://www.ensemblgenomes.org/id/b3282 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000049 GO_function GO:0003725 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003725 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GO_function GO:0061710 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061710 GO_process GO:0002949 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002949 GO_process GO:0006364 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006364 GO_process GO:0006450 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006450 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.90.870.10 http://www.cathdb.info/version/latest/superfamily/3.90.870.10 GeneID 947783 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947783 HAMAP MF_01852 http://hamap.expasy.org/unirule/MF_01852 HOGENOM HOG000076163 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000076163&db=HOGENOM6 InParanoid P45748 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P45748 IntAct P45748 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45748* IntEnz 2.7.7.87 {ECO:0000255|HAMAP-Rule:MF_01852} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.87 {ECO:0000255|HAMAP-Rule:MF_01852} InterPro IPR006070 http://www.ebi.ac.uk/interpro/entry/IPR006070 InterPro IPR017945 http://www.ebi.ac.uk/interpro/entry/IPR017945 InterPro IPR023535 http://www.ebi.ac.uk/interpro/entry/IPR023535 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW3243 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3243 KEGG_Gene eco:b3282 http://www.genome.jp/dbget-bin/www_bget?eco:b3282 KEGG_Orthology KO:K07566 http://www.genome.jp/dbget-bin/www_bget?KO:K07566 MINT MINT-1230775 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1230775 OMA FGLGCNP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FGLGCNP PDB 1HRU http://www.ebi.ac.uk/pdbe-srv/view/entry/1HRU PDB 2MX1 http://www.ebi.ac.uk/pdbe-srv/view/entry/2MX1 PDBsum 1HRU http://www.ebi.ac.uk/pdbsum/1HRU PDBsum 2MX1 http://www.ebi.ac.uk/pdbsum/2MX1 PROSITE PS51163 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51163 PSORT swissprot:TSAC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TSAC_ECOLI PSORT-B swissprot:TSAC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TSAC_ECOLI PSORT2 swissprot:TSAC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TSAC_ECOLI Pfam PF01300 http://pfam.xfam.org/family/PF01300 Phobius swissprot:TSAC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TSAC_ECOLI PhylomeDB P45748 http://phylomedb.org/?seqid=P45748 ProteinModelPortal P45748 http://www.proteinmodelportal.org/query/uniprot/P45748 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 11206077 http://www.ncbi.nlm.nih.gov/pubmed/11206077 PubMed 15716138 http://www.ncbi.nlm.nih.gov/pubmed/15716138 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19287007 http://www.ncbi.nlm.nih.gov/pubmed/19287007 PubMed 21285948 http://www.ncbi.nlm.nih.gov/pubmed/21285948 PubMed 21775474 http://www.ncbi.nlm.nih.gov/pubmed/21775474 PubMed 22378793 http://www.ncbi.nlm.nih.gov/pubmed/22378793 PubMed 23072323 http://www.ncbi.nlm.nih.gov/pubmed/23072323 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417741 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417741 RefSeq WP_001301412 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001301412 SMR P45748 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45748 STRING 511145.b3282 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3282&targetmode=cogs STRING COG0009 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0009&targetmode=cogs SUPFAM SSF55821 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55821 UniProtKB TSAC_ECOLI http://www.uniprot.org/uniprot/TSAC_ECOLI UniProtKB-AC P45748 http://www.uniprot.org/uniprot/P45748 charge swissprot:TSAC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TSAC_ECOLI eggNOG COG0009 http://eggnogapi.embl.de/nog_data/html/tree/COG0009 eggNOG ENOG4105EK0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EK0 epestfind swissprot:TSAC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TSAC_ECOLI garnier swissprot:TSAC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TSAC_ECOLI helixturnhelix swissprot:TSAC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TSAC_ECOLI hmoment swissprot:TSAC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TSAC_ECOLI iep swissprot:TSAC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TSAC_ECOLI inforesidue swissprot:TSAC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TSAC_ECOLI octanol swissprot:TSAC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TSAC_ECOLI pepcoil swissprot:TSAC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TSAC_ECOLI pepdigest swissprot:TSAC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TSAC_ECOLI pepinfo swissprot:TSAC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TSAC_ECOLI pepnet swissprot:TSAC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TSAC_ECOLI pepstats swissprot:TSAC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TSAC_ECOLI pepwheel swissprot:TSAC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TSAC_ECOLI pepwindow swissprot:TSAC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TSAC_ECOLI sigcleave swissprot:TSAC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TSAC_ECOLI ## Database ID URL or Descriptions # AltName Dipeptide/tripeptide:H(+) symporter DtpC {ECO 0000305} # BIOPHYSICOCHEMICAL PROPERTIES DTPC_ECOLI Kinetic parameters KM=0.07 mM for Ala-Lys {ECO 0000269|PubMed 24440353}; KM=0.51 mM for Lys-Ala {ECO 0000269|PubMed 24440353}; pH dependence Optimum pH is around 6.5. {ECO 0000269|PubMed 21933132}; # BRENDA 3.6.3.43 2026 # BioGrid 4261129 143 # CDD cd06174 MFS # EcoGene EG12469 dtpC # FUNCTION DTPC_ECOLI Proton-dependent permease that transports di- and tripeptides. Shows significantly higher specificity towards dipeptides than tripeptides. Has a preference for dipeptides with a C-terminal Lys residue. Can bind Ala-Lys, Lys-Ala, Ala-Ala. Can also transport alanine and trialanine. {ECO 0000269|PubMed 19703419, ECO 0000269|PubMed 21933132, ECO 0000269|PubMed 22940668, ECO 0000269|PubMed 24440353}. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function DTPC_ECOLI GO 0015333 peptide proton symporter activity; IMP EcoCyc. # GO_function GO:0015078 hydrogen ion transmembrane transporter activity; IMP:EcoCyc. # GO_function GO:0042937 tripeptide transporter activity; IMP:EcoCyc. # GO_function GO:0071916 dipeptide transmembrane transporter activity; IMP:EcoCyc. # GO_process GO:0015031 protein transport; IEA:UniProtKB-KW. # GO_process GO:0035442 dipeptide transmembrane transport; IMP:EcoCyc. # GO_process GO:0035443 tripeptide transmembrane transport; IMP:EcoCyc. # GO_process GO:1902600 hydrogen ion transmembrane transport; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # InterPro IPR000109 POT_fam # InterPro IPR005279 Dipep/tripep_permease # InterPro IPR018456 PTR2_symporter_CS # InterPro IPR020846 MFS_dom # Organism DTPC_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11654 PTHR11654 # PATRIC 32123827 VBIEscCol129921_4262 # PIR S56359 S56359 # PROSITE PS01022 PTR2_1 # PROSITE PS01023 PTR2_2 # PROSITE PS50850 MFS # Pfam PF00854 PTR2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Dipeptide and tripeptide permease C {ECO 0000305} # RefSeq NP_418554 NC_000913.3 # RefSeq WP_000856829 NZ_LN832404.1 # SIMILARITY Belongs to the PTR2/POT transporter (TC 2.A.17) family. {ECO 0000305}. # SUBCELLULAR LOCATION DTPC_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000255}. # SUBUNIT Monomer. {ECO:0000269|PubMed 22940668}. # SUPFAM SSF103473 SSF103473; 2 # TCDB 2.A.17.1 the proton-dependent oligopeptide transporter (pot/ptr) family # TIGRFAMs TIGR00924 yjdL_sub1_fam # eggNOG COG3104 LUCA # eggNOG ENOG4105DUX Bacteria BLAST swissprot:DTPC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DTPC_ECOLI BioCyc ECOL316407:JW4091-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4091-MONOMER BioCyc EcoCyc:YJDL-MONOMER http://biocyc.org/getid?id=EcoCyc:YJDL-MONOMER BioCyc MetaCyc:YJDL-MONOMER http://biocyc.org/getid?id=MetaCyc:YJDL-MONOMER COG COG3104 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3104 DOI 10.1016/j.bbrc.2009.08.098 http://dx.doi.org/10.1016/j.bbrc.2009.08.098 DOI 10.1016/j.febslet.2014.01.004 http://dx.doi.org/10.1016/j.febslet.2014.01.004 DOI 10.1016/j.jmb.2009.09.048 http://dx.doi.org/10.1016/j.jmb.2009.09.048 DOI 10.1016/j.peptides.2012.08.012 http://dx.doi.org/10.1016/j.peptides.2012.08.012 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/23.12.2105 http://dx.doi.org/10.1093/nar/23.12.2105 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.2174/092986612799363109 http://dx.doi.org/10.2174/092986612799363109 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U14003 http://www.ebi.ac.uk/ena/data/view/U14003 EchoBASE EB2362 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2362 EcoGene EG12469 http://www.ecogene.org/geneInfo.php?eg_id=EG12469 EnsemblBacteria AAC77091 http://www.ensemblgenomes.org/id/AAC77091 EnsemblBacteria AAC77091 http://www.ensemblgenomes.org/id/AAC77091 EnsemblBacteria BAE78133 http://www.ensemblgenomes.org/id/BAE78133 EnsemblBacteria BAE78133 http://www.ensemblgenomes.org/id/BAE78133 EnsemblBacteria BAE78133 http://www.ensemblgenomes.org/id/BAE78133 EnsemblBacteria b4130 http://www.ensemblgenomes.org/id/b4130 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0015078 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015078 GO_function GO:0015333 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015333 GO_function GO:0042937 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042937 GO_function GO:0071916 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071916 GO_process GO:0015031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031 GO_process GO:0035442 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035442 GO_process GO:0035443 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035443 GO_process GO:1902600 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1902600 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 948644 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948644 HOGENOM HOG000243450 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000243450&db=HOGENOM6 InParanoid P39276 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P39276 InterPro IPR000109 http://www.ebi.ac.uk/interpro/entry/IPR000109 InterPro IPR005279 http://www.ebi.ac.uk/interpro/entry/IPR005279 InterPro IPR018456 http://www.ebi.ac.uk/interpro/entry/IPR018456 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 KEGG_Gene ecj:JW4091 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4091 KEGG_Gene eco:b4130 http://www.genome.jp/dbget-bin/www_bget?eco:b4130 KEGG_Orthology KO:K03305 http://www.genome.jp/dbget-bin/www_bget?KO:K03305 OMA ISYLIMT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ISYLIMT PANTHER PTHR11654 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11654 PROSITE PS01022 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01022 PROSITE PS01023 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01023 PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:DTPC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DTPC_ECOLI PSORT-B swissprot:DTPC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DTPC_ECOLI PSORT2 swissprot:DTPC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DTPC_ECOLI Pfam PF00854 http://pfam.xfam.org/family/PF00854 Phobius swissprot:DTPC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DTPC_ECOLI PhylomeDB P39276 http://phylomedb.org/?seqid=P39276 ProteinModelPortal P39276 http://www.proteinmodelportal.org/query/uniprot/P39276 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 19703419 http://www.ncbi.nlm.nih.gov/pubmed/19703419 PubMed 19782088 http://www.ncbi.nlm.nih.gov/pubmed/19782088 PubMed 21933132 http://www.ncbi.nlm.nih.gov/pubmed/21933132 PubMed 22940668 http://www.ncbi.nlm.nih.gov/pubmed/22940668 PubMed 24440353 http://www.ncbi.nlm.nih.gov/pubmed/24440353 PubMed 7610040 http://www.ncbi.nlm.nih.gov/pubmed/7610040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418554 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418554 RefSeq WP_000856829 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000856829 STRING 511145.b4130 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4130&targetmode=cogs STRING COG3104 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3104&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.17.1 http://www.tcdb.org/search/result.php?tc=2.A.17.1 TIGRFAMs TIGR00924 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00924 UniProtKB DTPC_ECOLI http://www.uniprot.org/uniprot/DTPC_ECOLI UniProtKB-AC P39276 http://www.uniprot.org/uniprot/P39276 charge swissprot:DTPC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DTPC_ECOLI eggNOG COG3104 http://eggnogapi.embl.de/nog_data/html/tree/COG3104 eggNOG ENOG4105DUX http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DUX epestfind swissprot:DTPC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DTPC_ECOLI garnier swissprot:DTPC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DTPC_ECOLI helixturnhelix swissprot:DTPC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DTPC_ECOLI hmoment swissprot:DTPC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DTPC_ECOLI iep swissprot:DTPC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DTPC_ECOLI inforesidue swissprot:DTPC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DTPC_ECOLI octanol swissprot:DTPC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DTPC_ECOLI pepcoil swissprot:DTPC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DTPC_ECOLI pepdigest swissprot:DTPC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DTPC_ECOLI pepinfo swissprot:DTPC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DTPC_ECOLI pepnet swissprot:DTPC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DTPC_ECOLI pepstats swissprot:DTPC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DTPC_ECOLI pepwheel swissprot:DTPC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DTPC_ECOLI pepwindow swissprot:DTPC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DTPC_ECOLI sigcleave swissprot:DTPC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DTPC_ECOLI ## Database ID URL or Descriptions # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters: KM=2 uM for dethiobiotin {ECO 0000269|PubMed:8142361}; # BRENDA 2.8.1 2026 # BioGrid 4259949 7 # CATALYTIC ACTIVITY BIOB_ECOLI Dethiobiotin + sulfur-(sulfur carrier) + 2 S- adenosyl-L-methionine + 2 reduced [2Fe-2S] ferredoxin = biotin + (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine + 2 oxidized [2Fe-2S] ferredoxin. {ECO 0000269|PubMed 11862544, ECO 0000269|PubMed 17014080, ECO 0000269|PubMed 8142361}. # COFACTOR BIOB_ECOLI Name=[2Fe-2S] cluster; Xref=ChEBI CHEBI 49601; Evidence={ECO 0000269|PubMed 8142361}; Note=Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine. {ECO 0000269|PubMed 8142361}; # COFACTOR BIOB_ECOLI Name=[4Fe-4S] cluster; Xref=ChEBI CHEBI 49883; Evidence={ECO 0000269|PubMed 8142361}; Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. {ECO 0000269|PubMed 8142361}; # DrugBank DB03754 Tris # EcoGene EG10118 bioB # FUNCTION BIOB_ECOLI Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism. {ECO 0000269|PubMed 8142361}. # GO_function GO:0004076 biotin synthase activity; IDA:EcoCyc. # GO_function GO:0005506 iron ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0051537 2 iron, 2 sulfur cluster binding; IDA:EcoCyc. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IDA:EcoCyc. # GO_process GO:0009102 biotin biosynthetic process; IMP:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.20.20.70 -; 1. # HAMAP MF_01694 BioB # INTERACTION BIOB_ECOLI Q47147 yafJ; NbExp=4; IntAct=EBI-557917, EBI-1114805; # IntAct P12996 17 # InterPro IPR002684 Biotin_synth/BioAB # InterPro IPR006638 Elp3/MiaB/NifB # InterPro IPR007197 rSAM # InterPro IPR010722 BATS_dom # InterPro IPR013785 Aldolase_TIM # InterPro IPR024177 Biotin_synthase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00780 Biotin metabolism # Organism BIOB_ECOLI Escherichia coli (strain K12) # PATHWAY Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate step 2/2. # PATRIC 32116751 VBIEscCol129921_0801 # PDB 1R30 X-ray; 3.40 A; A/B=2-346 # PIR JC2517 SYECBB # PIRSF PIRSF001619 Biotin_synth # Pfam PF04055 Radical_SAM # Pfam PF06968 BATS # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BIOB_ECOLI Biotin synthase # RefSeq NP_415296 NC_000913.3 # RefSeq WP_000951213 NZ_LN832404.1 # SIMILARITY Belongs to the radical SAM superfamily. Biotin synthase family. {ECO 0000305}. # SMART SM00729 Elp3 # SMART SM00876 BATS # SUBUNIT Homodimer. {ECO:0000269|PubMed 8142361}. # TIGRFAMs TIGR00433 bioB # UniPathway UPA00078 UER00162 # eggNOG COG0502 LUCA # eggNOG ENOG4105CZF Bacteria BLAST swissprot:BIOB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BIOB_ECOLI BioCyc ECOL316407:JW0758-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0758-MONOMER BioCyc EcoCyc:BIOTIN-SYN-MONOMER http://biocyc.org/getid?id=EcoCyc:BIOTIN-SYN-MONOMER BioCyc MetaCyc:BIOTIN-SYN-MONOMER http://biocyc.org/getid?id=MetaCyc:BIOTIN-SYN-MONOMER COG COG0502 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0502 DIP DIP-9220N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9220N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1007/s007750100268 http://dx.doi.org/10.1007/s007750100268 DOI 10.1016/j.bbrc.2009.02.089 http://dx.doi.org/10.1016/j.bbrc.2009.02.089 DOI 10.1021/bi00178a020 http://dx.doi.org/10.1021/bi00178a020 DOI 10.1021/bi060662m http://dx.doi.org/10.1021/bi060662m DOI 10.1021/ja0283044 http://dx.doi.org/10.1021/ja0283044 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M111324200 http://dx.doi.org/10.1074/jbc.M111324200 DOI 10.1093/oxfordjournals.jbchem.a003028 http://dx.doi.org/10.1093/oxfordjournals.jbchem.a003028 DOI 10.1110/ps.0302203 http://dx.doi.org/10.1110/ps.0302203 DOI 10.1126/science.1088493 http://dx.doi.org/10.1126/science.1088493 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DrugBank DB03754 http://www.drugbank.ca/drugs/DB03754 EC_number EC:2.8.1.6 {ECO:0000269|PubMed:11862544, ECO:0000269|PubMed:17014080, ECO:0000269|PubMed:8142361} http://www.genome.jp/dbget-bin/www_bget?EC:2.8.1.6 {ECO:0000269|PubMed:11862544, ECO:0000269|PubMed:17014080, ECO:0000269|PubMed:8142361} EMBL A11530 http://www.ebi.ac.uk/ena/data/view/A11530 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J04423 http://www.ebi.ac.uk/ena/data/view/J04423 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.8.1.6 {ECO:0000269|PubMed:11862544, ECO:0000269|PubMed:17014080, ECO:0000269|PubMed:8142361} http://enzyme.expasy.org/EC/2.8.1.6 {ECO:0000269|PubMed:11862544, ECO:0000269|PubMed:17014080, ECO:0000269|PubMed:8142361} EchoBASE EB0116 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0116 EcoGene EG10118 http://www.ecogene.org/geneInfo.php?eg_id=EG10118 EnsemblBacteria AAC73862 http://www.ensemblgenomes.org/id/AAC73862 EnsemblBacteria AAC73862 http://www.ensemblgenomes.org/id/AAC73862 EnsemblBacteria BAE76362 http://www.ensemblgenomes.org/id/BAE76362 EnsemblBacteria BAE76362 http://www.ensemblgenomes.org/id/BAE76362 EnsemblBacteria BAE76362 http://www.ensemblgenomes.org/id/BAE76362 EnsemblBacteria b0775 http://www.ensemblgenomes.org/id/b0775 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004076 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004076 GO_function GO:0005506 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005506 GO_function GO:0051537 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051537 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GO_process GO:0009102 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009102 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.20.20.70 http://www.cathdb.info/version/latest/superfamily/3.20.20.70 GeneID 945370 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945370 HAMAP MF_01694 http://hamap.expasy.org/unirule/MF_01694 HOGENOM HOG000239957 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000239957&db=HOGENOM6 InParanoid P12996 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P12996 IntAct P12996 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P12996* IntEnz 2.8.1.6 {ECO:0000269|PubMed:11862544, ECO:0000269|PubMed:17014080, ECO:0000269|PubMed:8142361} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.8.1.6 {ECO:0000269|PubMed:11862544, ECO:0000269|PubMed:17014080, ECO:0000269|PubMed:8142361} InterPro IPR002684 http://www.ebi.ac.uk/interpro/entry/IPR002684 InterPro IPR006638 http://www.ebi.ac.uk/interpro/entry/IPR006638 InterPro IPR007197 http://www.ebi.ac.uk/interpro/entry/IPR007197 InterPro IPR010722 http://www.ebi.ac.uk/interpro/entry/IPR010722 InterPro IPR013785 http://www.ebi.ac.uk/interpro/entry/IPR013785 InterPro IPR024177 http://www.ebi.ac.uk/interpro/entry/IPR024177 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0758 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0758 KEGG_Gene eco:b0775 http://www.genome.jp/dbget-bin/www_bget?eco:b0775 KEGG_Orthology KO:K01012 http://www.genome.jp/dbget-bin/www_bget?KO:K01012 KEGG_Pathway ko00780 http://www.genome.jp/kegg-bin/show_pathway?ko00780 KEGG_Reaction rn:R01078 http://www.genome.jp/dbget-bin/www_bget?rn:R01078 MINT MINT-1292998 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1292998 OMA PFDFIRM http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PFDFIRM PDB 1R30 http://www.ebi.ac.uk/pdbe-srv/view/entry/1R30 PDBsum 1R30 http://www.ebi.ac.uk/pdbsum/1R30 PSORT swissprot:BIOB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BIOB_ECOLI PSORT-B swissprot:BIOB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BIOB_ECOLI PSORT2 swissprot:BIOB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BIOB_ECOLI Pfam PF04055 http://pfam.xfam.org/family/PF04055 Pfam PF06968 http://pfam.xfam.org/family/PF06968 Phobius swissprot:BIOB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BIOB_ECOLI PhylomeDB P12996 http://phylomedb.org/?seqid=P12996 ProteinModelPortal P12996 http://www.proteinmodelportal.org/query/uniprot/P12996 PubMed 11686925 http://www.ncbi.nlm.nih.gov/pubmed/11686925 PubMed 11834738 http://www.ncbi.nlm.nih.gov/pubmed/11834738 PubMed 11862544 http://www.ncbi.nlm.nih.gov/pubmed/11862544 PubMed 12440894 http://www.ncbi.nlm.nih.gov/pubmed/12440894 PubMed 12824504 http://www.ncbi.nlm.nih.gov/pubmed/12824504 PubMed 14704425 http://www.ncbi.nlm.nih.gov/pubmed/14704425 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17014080 http://www.ncbi.nlm.nih.gov/pubmed/17014080 PubMed 19245793 http://www.ncbi.nlm.nih.gov/pubmed/19245793 PubMed 3058702 http://www.ncbi.nlm.nih.gov/pubmed/3058702 PubMed 8142361 http://www.ncbi.nlm.nih.gov/pubmed/8142361 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_415296 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415296 RefSeq WP_000951213 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000951213 SMART SM00729 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00729 SMART SM00876 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00876 SMR P12996 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P12996 STRING 511145.b0775 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0775&targetmode=cogs STRING COG0502 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0502&targetmode=cogs TIGRFAMs TIGR00433 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00433 UniProtKB BIOB_ECOLI http://www.uniprot.org/uniprot/BIOB_ECOLI UniProtKB-AC P12996 http://www.uniprot.org/uniprot/P12996 charge swissprot:BIOB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BIOB_ECOLI eggNOG COG0502 http://eggnogapi.embl.de/nog_data/html/tree/COG0502 eggNOG ENOG4105CZF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CZF epestfind swissprot:BIOB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BIOB_ECOLI garnier swissprot:BIOB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BIOB_ECOLI helixturnhelix swissprot:BIOB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BIOB_ECOLI hmoment swissprot:BIOB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BIOB_ECOLI iep swissprot:BIOB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BIOB_ECOLI inforesidue swissprot:BIOB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BIOB_ECOLI octanol swissprot:BIOB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BIOB_ECOLI pepcoil swissprot:BIOB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BIOB_ECOLI pepdigest swissprot:BIOB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BIOB_ECOLI pepinfo swissprot:BIOB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BIOB_ECOLI pepnet swissprot:BIOB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BIOB_ECOLI pepstats swissprot:BIOB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BIOB_ECOLI pepwheel swissprot:BIOB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BIOB_ECOLI pepwindow swissprot:BIOB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BIOB_ECOLI sigcleave swissprot:BIOB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BIOB_ECOLI ## Database ID URL or Descriptions # BioGrid 4261054 17 # EcoGene EG12709 yedI # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # IntAct P46125 2 # InterPro IPR008526 YedI # Organism YEDI_ECOLI Escherichia coli (strain K12) # PATRIC 32119245 VBIEscCol129921_2037 # PIR B64960 B64960 # PIRSF PIRSF016660 YedI # Pfam PF05661 DUF808 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEDI_ECOLI Inner membrane protein YedI # RefSeq NP_416467 NC_000913.3 # RefSeq WP_000922686 NZ_LN832404.1 # SUBCELLULAR LOCATION YEDI_ECOLI Cell inner membrane; Multi-pass membrane protein. # eggNOG COG2354 LUCA # eggNOG ENOG4105CKW Bacteria BLAST swissprot:YEDI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEDI_ECOLI BioCyc ECOL316407:JW1941-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1941-MONOMER BioCyc EcoCyc:EG12709-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12709-MONOMER COG COG2354 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2354 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1093/nar/17.14.5844 http://dx.doi.org/10.1093/nar/17.14.5844 DOI 10.1093/nar/23.17.3554 http://dx.doi.org/10.1093/nar/23.17.3554 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X13330 http://www.ebi.ac.uk/ena/data/view/X13330 EchoBASE EB2571 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2571 EcoGene EG12709 http://www.ecogene.org/geneInfo.php?eg_id=EG12709 EnsemblBacteria AAC75024 http://www.ensemblgenomes.org/id/AAC75024 EnsemblBacteria AAC75024 http://www.ensemblgenomes.org/id/AAC75024 EnsemblBacteria BAA15785 http://www.ensemblgenomes.org/id/BAA15785 EnsemblBacteria BAA15785 http://www.ensemblgenomes.org/id/BAA15785 EnsemblBacteria BAA15785 http://www.ensemblgenomes.org/id/BAA15785 EnsemblBacteria b1958 http://www.ensemblgenomes.org/id/b1958 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GeneID 946465 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946465 HOGENOM HOG000244091 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000244091&db=HOGENOM6 InParanoid P46125 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P46125 IntAct P46125 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P46125* InterPro IPR008526 http://www.ebi.ac.uk/interpro/entry/IPR008526 KEGG_Gene ecj:JW1941 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1941 KEGG_Gene eco:b1958 http://www.genome.jp/dbget-bin/www_bget?eco:b1958 KEGG_Orthology KO:K09781 http://www.genome.jp/dbget-bin/www_bget?KO:K09781 OMA FLCFEGF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FLCFEGF PSORT swissprot:YEDI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEDI_ECOLI PSORT-B swissprot:YEDI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEDI_ECOLI PSORT2 swissprot:YEDI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEDI_ECOLI Pfam PF05661 http://pfam.xfam.org/family/PF05661 Phobius swissprot:YEDI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEDI_ECOLI PhylomeDB P46125 http://phylomedb.org/?seqid=P46125 ProteinModelPortal P46125 http://www.proteinmodelportal.org/query/uniprot/P46125 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2527357 http://www.ncbi.nlm.nih.gov/pubmed/2527357 PubMed 7567469 http://www.ncbi.nlm.nih.gov/pubmed/7567469 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416467 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416467 RefSeq WP_000922686 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000922686 STRING 511145.b1958 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1958&targetmode=cogs STRING COG2354 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2354&targetmode=cogs UniProtKB YEDI_ECOLI http://www.uniprot.org/uniprot/YEDI_ECOLI UniProtKB-AC P46125 http://www.uniprot.org/uniprot/P46125 charge swissprot:YEDI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEDI_ECOLI eggNOG COG2354 http://eggnogapi.embl.de/nog_data/html/tree/COG2354 eggNOG ENOG4105CKW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CKW epestfind swissprot:YEDI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEDI_ECOLI garnier swissprot:YEDI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEDI_ECOLI helixturnhelix swissprot:YEDI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEDI_ECOLI hmoment swissprot:YEDI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEDI_ECOLI iep swissprot:YEDI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEDI_ECOLI inforesidue swissprot:YEDI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEDI_ECOLI octanol swissprot:YEDI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEDI_ECOLI pepcoil swissprot:YEDI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEDI_ECOLI pepdigest swissprot:YEDI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEDI_ECOLI pepinfo swissprot:YEDI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEDI_ECOLI pepnet swissprot:YEDI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEDI_ECOLI pepstats swissprot:YEDI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEDI_ECOLI pepwheel swissprot:YEDI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEDI_ECOLI pepwindow swissprot:YEDI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEDI_ECOLI sigcleave swissprot:YEDI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEDI_ECOLI ## Database ID URL or Descriptions # BioGrid 4259654 8 # EcoGene EG11941 yjcF # IntAct P32704 5 # InterPro IPR001646 5peptide_repeat # Organism YJCF_ECOLI Escherichia coli (strain K12) # PATRIC 32123681 VBIEscCol129921_4189 # PIR A65215 A65215 # Pfam PF00805 Pentapeptide; 3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YJCF_ECOLI Uncharacterized protein YjcF # RefSeq NP_418490 NC_000913.3 # RefSeq WP_001270094 NZ_LN832404.1 # eggNOG COG1357 LUCA BLAST swissprot:YJCF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YJCF_ECOLI BioCyc ECOL316407:JW4027-MONOMER http://biocyc.org/getid?id=ECOL316407:JW4027-MONOMER BioCyc EcoCyc:EG11941-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11941-MONOMER DIP DIP-12551N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12551N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/21.23.5408 http://dx.doi.org/10.1093/nar/21.23.5408 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00006 http://www.ebi.ac.uk/ena/data/view/U00006 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1885 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1885 EcoGene EG11941 http://www.ecogene.org/geneInfo.php?eg_id=EG11941 EnsemblBacteria AAC77036 http://www.ensemblgenomes.org/id/AAC77036 EnsemblBacteria AAC77036 http://www.ensemblgenomes.org/id/AAC77036 EnsemblBacteria BAE78068 http://www.ensemblgenomes.org/id/BAE78068 EnsemblBacteria BAE78068 http://www.ensemblgenomes.org/id/BAE78068 EnsemblBacteria BAE78068 http://www.ensemblgenomes.org/id/BAE78068 EnsemblBacteria b4066 http://www.ensemblgenomes.org/id/b4066 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 948576 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948576 HOGENOM HOG000009675 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009675&db=HOGENOM6 InParanoid P32704 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P32704 IntAct P32704 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P32704* InterPro IPR001646 http://www.ebi.ac.uk/interpro/entry/IPR001646 KEGG_Gene ecj:JW4027 http://www.genome.jp/dbget-bin/www_bget?ecj:JW4027 KEGG_Gene eco:b4066 http://www.genome.jp/dbget-bin/www_bget?eco:b4066 MINT MINT-1238461 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1238461 OMA QTEDNIH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QTEDNIH PSORT swissprot:YJCF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YJCF_ECOLI PSORT-B swissprot:YJCF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YJCF_ECOLI PSORT2 swissprot:YJCF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YJCF_ECOLI Pfam PF00805 http://pfam.xfam.org/family/PF00805 Phobius swissprot:YJCF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YJCF_ECOLI PhylomeDB P32704 http://phylomedb.org/?seqid=P32704 ProteinModelPortal P32704 http://www.proteinmodelportal.org/query/uniprot/P32704 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8265357 http://www.ncbi.nlm.nih.gov/pubmed/8265357 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418490 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418490 RefSeq WP_001270094 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001270094 SMR P32704 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P32704 STRING 511145.b4066 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4066&targetmode=cogs UniProtKB YJCF_ECOLI http://www.uniprot.org/uniprot/YJCF_ECOLI UniProtKB-AC P32704 http://www.uniprot.org/uniprot/P32704 charge swissprot:YJCF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YJCF_ECOLI eggNOG COG1357 http://eggnogapi.embl.de/nog_data/html/tree/COG1357 epestfind swissprot:YJCF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YJCF_ECOLI garnier swissprot:YJCF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YJCF_ECOLI helixturnhelix swissprot:YJCF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YJCF_ECOLI hmoment swissprot:YJCF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YJCF_ECOLI iep swissprot:YJCF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YJCF_ECOLI inforesidue swissprot:YJCF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YJCF_ECOLI octanol swissprot:YJCF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YJCF_ECOLI pepcoil swissprot:YJCF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YJCF_ECOLI pepdigest swissprot:YJCF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YJCF_ECOLI pepinfo swissprot:YJCF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YJCF_ECOLI pepnet swissprot:YJCF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YJCF_ECOLI pepstats swissprot:YJCF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YJCF_ECOLI pepwheel swissprot:YJCF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YJCF_ECOLI pepwindow swissprot:YJCF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YJCF_ECOLI sigcleave swissprot:YJCF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YJCF_ECOLI ## Database ID URL or Descriptions # BioGrid 4262124 122 # EcoGene EG14006 ynjD # FUNCTION YNJD_ECOLI Probably part of a binding-protein-dependent transport system YnjCD. Probably responsible for energy coupling to the transport system. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016887 ATPase activity; IEA:InterPro. # GO_process GO:0006810 transport; IEA:UniProtKB-KW. # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # Gene3D 3.40.50.300 -; 1. # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00192 Putative thiamine transport system # KEGG_Brite ko02000 Transporters # Organism YNJD_ECOLI Escherichia coli (strain K12) # PATRIC 32118823 VBIEscCol129921_1829 # PIR D64935 D64935 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # Pfam PF00005 ABC_tran # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YNJD_ECOLI Uncharacterized ABC transporter ATP-binding protein YnjD # RefSeq NP_416270 NC_000913.3 # RefSeq WP_001300558 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA # SUPFAM SSF52540 SSF52540 # eggNOG COG4136 LUCA # eggNOG ENOG4108VGW Bacteria BLAST swissprot:YNJD_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YNJD_ECOLI BioCyc ECOL316407:JW5286-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5286-MONOMER BioCyc EcoCyc:YNJD-MONOMER http://biocyc.org/getid?id=EcoCyc:YNJD-MONOMER COG COG4136 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4136 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3762 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3762 EcoGene EG14006 http://www.ecogene.org/geneInfo.php?eg_id=EG14006 EnsemblBacteria AAC74826 http://www.ensemblgenomes.org/id/AAC74826 EnsemblBacteria AAC74826 http://www.ensemblgenomes.org/id/AAC74826 EnsemblBacteria BAA15547 http://www.ensemblgenomes.org/id/BAA15547 EnsemblBacteria BAA15547 http://www.ensemblgenomes.org/id/BAA15547 EnsemblBacteria BAA15547 http://www.ensemblgenomes.org/id/BAA15547 EnsemblBacteria b1756 http://www.ensemblgenomes.org/id/b1756 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GO_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 944965 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944965 InParanoid P76909 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P76909 InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5286 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5286 KEGG_Gene eco:b1756 http://www.genome.jp/dbget-bin/www_bget?eco:b1756 KEGG_Orthology KO:K05779 http://www.genome.jp/dbget-bin/www_bget?KO:K05779 OMA PLFREVN http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PLFREVN PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:YNJD_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YNJD_ECOLI PSORT-B swissprot:YNJD_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YNJD_ECOLI PSORT2 swissprot:YNJD_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YNJD_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Phobius swissprot:YNJD_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YNJD_ECOLI PhylomeDB P76909 http://phylomedb.org/?seqid=P76909 ProteinModelPortal P76909 http://www.proteinmodelportal.org/query/uniprot/P76909 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416270 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416270 RefSeq WP_001300558 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300558 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 SMR P76909 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P76909 STRING 511145.b1756 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1756&targetmode=cogs STRING COG4136 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4136&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 UniProtKB YNJD_ECOLI http://www.uniprot.org/uniprot/YNJD_ECOLI UniProtKB-AC P76909 http://www.uniprot.org/uniprot/P76909 charge swissprot:YNJD_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YNJD_ECOLI eggNOG COG4136 http://eggnogapi.embl.de/nog_data/html/tree/COG4136 eggNOG ENOG4108VGW http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108VGW epestfind swissprot:YNJD_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YNJD_ECOLI garnier swissprot:YNJD_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YNJD_ECOLI helixturnhelix swissprot:YNJD_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YNJD_ECOLI hmoment swissprot:YNJD_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YNJD_ECOLI iep swissprot:YNJD_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YNJD_ECOLI inforesidue swissprot:YNJD_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YNJD_ECOLI octanol swissprot:YNJD_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YNJD_ECOLI pepcoil swissprot:YNJD_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YNJD_ECOLI pepdigest swissprot:YNJD_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YNJD_ECOLI pepinfo swissprot:YNJD_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YNJD_ECOLI pepnet swissprot:YNJD_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YNJD_ECOLI pepstats swissprot:YNJD_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YNJD_ECOLI pepwheel swissprot:YNJD_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YNJD_ECOLI pepwindow swissprot:YNJD_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YNJD_ECOLI sigcleave swissprot:YNJD_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YNJD_ECOLI ## Database ID URL or Descriptions # GO_function GO:0003676 nucleic acid binding; IEA:InterPro. # GOslim_function GO:0003674 molecular_function # Gene3D 3.30.420.10 -; 1. # InterPro IPR012337 RNaseH-like_dom # Organism YUAL_ECOLI Escherichia coli (strain K12) # RecName YUAL_ECOLI Uncharacterized protein YuaL # RefSeq NP_061402 NC_002483.1 # RefSeq WP_000903255 NZ_CP014273.1 # SUPFAM SSF53098 SSF53098 BLAST swissprot:YUAL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YUAL_ECOLI EMBL AP001918 http://www.ebi.ac.uk/ena/data/view/AP001918 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003676 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003676 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 Gene3D 3.30.420.10 http://www.cathdb.info/version/latest/superfamily/3.30.420.10 GeneID 1263539 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1263539 InterPro IPR012337 http://www.ebi.ac.uk/interpro/entry/IPR012337 OMA YGDCHAV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YGDCHAV PSORT swissprot:YUAL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YUAL_ECOLI PSORT-B swissprot:YUAL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YUAL_ECOLI PSORT2 swissprot:YUAL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YUAL_ECOLI Phobius swissprot:YUAL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YUAL_ECOLI ProteinModelPortal Q9JMS8 http://www.proteinmodelportal.org/query/uniprot/Q9JMS8 RefSeq NP_061402 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_061402 RefSeq WP_000903255 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000903255 SUPFAM SSF53098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53098 UniProtKB YUAL_ECOLI http://www.uniprot.org/uniprot/YUAL_ECOLI UniProtKB-AC Q9JMS8 http://www.uniprot.org/uniprot/Q9JMS8 charge swissprot:YUAL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YUAL_ECOLI epestfind swissprot:YUAL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YUAL_ECOLI garnier swissprot:YUAL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YUAL_ECOLI helixturnhelix swissprot:YUAL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YUAL_ECOLI hmoment swissprot:YUAL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YUAL_ECOLI iep swissprot:YUAL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YUAL_ECOLI inforesidue swissprot:YUAL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YUAL_ECOLI octanol swissprot:YUAL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YUAL_ECOLI pepcoil swissprot:YUAL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YUAL_ECOLI pepdigest swissprot:YUAL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YUAL_ECOLI pepinfo swissprot:YUAL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YUAL_ECOLI pepnet swissprot:YUAL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YUAL_ECOLI pepstats swissprot:YUAL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YUAL_ECOLI pepwheel swissprot:YUAL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YUAL_ECOLI pepwindow swissprot:YUAL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YUAL_ECOLI sigcleave swissprot:YUAL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YUAL_ECOLI ## Database ID URL or Descriptions # BioGrid 4263334 141 # CDD cd06174 MFS # EcoGene EG12219 yhhS # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0055085 transmembrane transport; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0055085 transmembrane transport # HAMAP MF_01118 UPF0226 # InterPro IPR011701 MFS # InterPro IPR020846 MFS_dom # InterPro IPR023008 UPF0226_MFS # Organism YHHS_ECOLI Escherichia coli (strain K12) # PATRIC 32122390 VBIEscCol129921_3572 # PIR S47692 S47692 # PROSITE PS50850 MFS # Pfam PF07690 MFS_1; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHHS_ECOLI UPF0226 protein YhhS # RefSeq NP_417930 NC_000913.3 # RefSeq WP_001300943 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB18448.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the UPF0226 family. {ECO 0000305}. # SUBCELLULAR LOCATION YHHS_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF103473 SSF103473 # TCDB 2.A.1.46 the major facilitator superfamily (mfs) # eggNOG ENOG4105F9N Bacteria # eggNOG ENOG410XNX3 LUCA BLAST swissprot:YHHS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHHS_ECOLI BioCyc ECOL316407:JW5945-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5945-MONOMER BioCyc EcoCyc:YHHS-MONOMER http://biocyc.org/getid?id=EcoCyc:YHHS-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/22.13.2576 http://dx.doi.org/10.1093/nar/22.13.2576 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00039 http://www.ebi.ac.uk/ena/data/view/U00039 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB2133 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2133 EcoGene EG12219 http://www.ecogene.org/geneInfo.php?eg_id=EG12219 EnsemblBacteria AAC76498 http://www.ensemblgenomes.org/id/AAC76498 EnsemblBacteria AAC76498 http://www.ensemblgenomes.org/id/AAC76498 EnsemblBacteria BAE77820 http://www.ensemblgenomes.org/id/BAE77820 EnsemblBacteria BAE77820 http://www.ensemblgenomes.org/id/BAE77820 EnsemblBacteria BAE77820 http://www.ensemblgenomes.org/id/BAE77820 EnsemblBacteria b3473 http://www.ensemblgenomes.org/id/b3473 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 947982 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947982 HAMAP MF_01118 http://hamap.expasy.org/unirule/MF_01118 HOGENOM HOG000122488 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000122488&db=HOGENOM6 InParanoid P37621 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37621 InterPro IPR011701 http://www.ebi.ac.uk/interpro/entry/IPR011701 InterPro IPR020846 http://www.ebi.ac.uk/interpro/entry/IPR020846 InterPro IPR023008 http://www.ebi.ac.uk/interpro/entry/IPR023008 KEGG_Gene ecj:JW5945 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5945 KEGG_Gene eco:b3473 http://www.genome.jp/dbget-bin/www_bget?eco:b3473 OMA CAFVGAR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CAFVGAR PROSITE PS50850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50850 PSORT swissprot:YHHS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHHS_ECOLI PSORT-B swissprot:YHHS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHHS_ECOLI PSORT2 swissprot:YHHS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHHS_ECOLI Pfam PF07690 http://pfam.xfam.org/family/PF07690 Phobius swissprot:YHHS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHHS_ECOLI PhylomeDB P37621 http://phylomedb.org/?seqid=P37621 ProteinModelPortal P37621 http://www.proteinmodelportal.org/query/uniprot/P37621 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8041620 http://www.ncbi.nlm.nih.gov/pubmed/8041620 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417930 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417930 RefSeq WP_001300943 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001300943 STRING 511145.b3473 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3473&targetmode=cogs SUPFAM SSF103473 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF103473 TCDB 2.A.1.46 http://www.tcdb.org/search/result.php?tc=2.A.1.46 UniProtKB YHHS_ECOLI http://www.uniprot.org/uniprot/YHHS_ECOLI UniProtKB-AC P37621 http://www.uniprot.org/uniprot/P37621 charge swissprot:YHHS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHHS_ECOLI eggNOG ENOG4105F9N http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105F9N eggNOG ENOG410XNX3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG410XNX3 epestfind swissprot:YHHS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHHS_ECOLI garnier swissprot:YHHS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHHS_ECOLI helixturnhelix swissprot:YHHS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHHS_ECOLI hmoment swissprot:YHHS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHHS_ECOLI iep swissprot:YHHS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHHS_ECOLI inforesidue swissprot:YHHS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHHS_ECOLI octanol swissprot:YHHS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHHS_ECOLI pepcoil swissprot:YHHS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHHS_ECOLI pepdigest swissprot:YHHS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHHS_ECOLI pepinfo swissprot:YHHS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHHS_ECOLI pepnet swissprot:YHHS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHHS_ECOLI pepstats swissprot:YHHS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHHS_ECOLI pepwheel swissprot:YHHS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHHS_ECOLI pepwindow swissprot:YHHS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHHS_ECOLI sigcleave swissprot:YHHS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHHS_ECOLI ## Database ID URL or Descriptions # BioGrid 4262255 129 # CAUTION Could be the product of a pseudogene. {ECO 0000305}. # EcoGene EG13519 ypjC # InterPro IPR020227 Uncharacterised_YpjC # Organism YPJC_ECOLI Escherichia coli (strain K12) # PATRIC 48664710 VBIEscCol107702_2682 # PIR D65044 D65044 # ProDom PD094182 Uncharacterised_YpjC # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YPJC_ECOLI Putative uncharacterized protein YpjC # RefSeq WP_000961356 NZ_LN832404.1 BLAST swissprot:YPJC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YPJC_ECOLI BioCyc ECOL316407:JW5424-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5424-MONOMER BioCyc EcoCyc:G7385-MONOMER http://biocyc.org/getid?id=EcoCyc:G7385-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB3292 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3292 EcoGene EG13519 http://www.ecogene.org/geneInfo.php?eg_id=EG13519 EnsemblBacteria BAE76776 http://www.ensemblgenomes.org/id/BAE76776 EnsemblBacteria BAE76776 http://www.ensemblgenomes.org/id/BAE76776 EnsemblBacteria BAE76776 http://www.ensemblgenomes.org/id/BAE76776 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv HOGENOM HOG000078298 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000078298&db=HOGENOM6 InterPro IPR020227 http://www.ebi.ac.uk/interpro/entry/IPR020227 KEGG_Gene ecj:JW5424 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5424 OMA KNNEFNT http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KNNEFNT PSORT swissprot:YPJC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YPJC_ECOLI PSORT-B swissprot:YPJC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YPJC_ECOLI PSORT2 swissprot:YPJC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YPJC_ECOLI Phobius swissprot:YPJC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YPJC_ECOLI ProteinModelPortal P76613 http://www.proteinmodelportal.org/query/uniprot/P76613 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_000961356 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000961356 UniProtKB YPJC_ECOLI http://www.uniprot.org/uniprot/YPJC_ECOLI UniProtKB-AC P76613 http://www.uniprot.org/uniprot/P76613 charge swissprot:YPJC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YPJC_ECOLI epestfind swissprot:YPJC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YPJC_ECOLI garnier swissprot:YPJC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YPJC_ECOLI helixturnhelix swissprot:YPJC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YPJC_ECOLI hmoment swissprot:YPJC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YPJC_ECOLI iep swissprot:YPJC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YPJC_ECOLI inforesidue swissprot:YPJC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YPJC_ECOLI octanol swissprot:YPJC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YPJC_ECOLI pepcoil swissprot:YPJC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YPJC_ECOLI pepdigest swissprot:YPJC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YPJC_ECOLI pepinfo swissprot:YPJC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YPJC_ECOLI pepnet swissprot:YPJC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YPJC_ECOLI pepstats swissprot:YPJC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YPJC_ECOLI pepwheel swissprot:YPJC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YPJC_ECOLI pepwindow swissprot:YPJC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YPJC_ECOLI sigcleave swissprot:YPJC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YPJC_ECOLI ## Database ID URL or Descriptions # BioGrid 4262587 6 # EcoGene EG11696 yidH # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006979 response to oxidative stress; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0006950 response to stress # InterPro IPR003807 DUF202 # Organism YIDH_ECOLI Escherichia coli (strain K12) # PATRIC 32122843 VBIEscCol129921_3797 # PIR E65169 E65169 # Pfam PF02656 DUF202 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YIDH_ECOLI Inner membrane protein YidH # RefSeq NP_418132 NC_000913.3 # RefSeq WP_000703959 NZ_LN832404.1 # SIMILARITY To M.tuberculosis Rv2272. {ECO 0000305}. # SUBCELLULAR LOCATION YIDH_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 9.B.51.1 the uncharacterized duf202/yidh (yidh) family # eggNOG COG2149 LUCA # eggNOG ENOG4105VG5 Bacteria BLAST swissprot:YIDH_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YIDH_ECOLI BioCyc ECOL316407:JW3652-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3652-MONOMER BioCyc EcoCyc:EG11696-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11696-MONOMER COG COG2149 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2149 DIP DIP-47894N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-47894N DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1647 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1647 EcoGene EG11696 http://www.ecogene.org/geneInfo.php?eg_id=EG11696 EnsemblBacteria AAC76699 http://www.ensemblgenomes.org/id/AAC76699 EnsemblBacteria AAC76699 http://www.ensemblgenomes.org/id/AAC76699 EnsemblBacteria BAE77617 http://www.ensemblgenomes.org/id/BAE77617 EnsemblBacteria BAE77617 http://www.ensemblgenomes.org/id/BAE77617 EnsemblBacteria BAE77617 http://www.ensemblgenomes.org/id/BAE77617 EnsemblBacteria b3676 http://www.ensemblgenomes.org/id/b3676 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006979 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006979 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 948190 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948190 HOGENOM HOG000236086 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000236086&db=HOGENOM6 InParanoid P0ADM0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ADM0 InterPro IPR003807 http://www.ebi.ac.uk/interpro/entry/IPR003807 KEGG_Gene ecj:JW3652 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3652 KEGG_Gene eco:b3676 http://www.genome.jp/dbget-bin/www_bget?eco:b3676 KEGG_Orthology KO:K00389 http://www.genome.jp/dbget-bin/www_bget?KO:K00389 OMA CERAMRR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=CERAMRR PSORT swissprot:YIDH_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YIDH_ECOLI PSORT-B swissprot:YIDH_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YIDH_ECOLI PSORT2 swissprot:YIDH_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YIDH_ECOLI Pfam PF02656 http://pfam.xfam.org/family/PF02656 Phobius swissprot:YIDH_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YIDH_ECOLI PhylomeDB P0ADM0 http://phylomedb.org/?seqid=P0ADM0 ProteinModelPortal P0ADM0 http://www.proteinmodelportal.org/query/uniprot/P0ADM0 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418132 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418132 RefSeq WP_000703959 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000703959 STRING 511145.b3676 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3676&targetmode=cogs STRING COG2149 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2149&targetmode=cogs TCDB 9.B.51.1 http://www.tcdb.org/search/result.php?tc=9.B.51.1 UniProtKB YIDH_ECOLI http://www.uniprot.org/uniprot/YIDH_ECOLI UniProtKB-AC P0ADM0 http://www.uniprot.org/uniprot/P0ADM0 charge swissprot:YIDH_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YIDH_ECOLI eggNOG COG2149 http://eggnogapi.embl.de/nog_data/html/tree/COG2149 eggNOG ENOG4105VG5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VG5 epestfind swissprot:YIDH_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YIDH_ECOLI garnier swissprot:YIDH_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YIDH_ECOLI helixturnhelix swissprot:YIDH_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YIDH_ECOLI hmoment swissprot:YIDH_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YIDH_ECOLI iep swissprot:YIDH_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YIDH_ECOLI inforesidue swissprot:YIDH_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YIDH_ECOLI octanol swissprot:YIDH_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YIDH_ECOLI pepcoil swissprot:YIDH_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YIDH_ECOLI pepdigest swissprot:YIDH_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YIDH_ECOLI pepinfo swissprot:YIDH_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YIDH_ECOLI pepnet swissprot:YIDH_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YIDH_ECOLI pepstats swissprot:YIDH_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YIDH_ECOLI pepwheel swissprot:YIDH_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YIDH_ECOLI pepwindow swissprot:YIDH_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YIDH_ECOLI sigcleave swissprot:YIDH_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YIDH_ECOLI ## Database ID URL or Descriptions # BioGrid 4259203 13 # EcoGene EG12139 yfhG # InterPro IPR025262 QseG # Organism YFHG_ECOLI Escherichia coli (strain K12) # PATRIC 32120509 VBIEscCol129921_2657 # PIR A49940 A49940 # PTM YFHG_ECOLI Exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven. Can also be exported by the Sec system. # Pfam PF13942 Lipoprotein_20 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YFHG_ECOLI Uncharacterized protein YfhG # RefSeq NP_417050 NC_000913.3 # RefSeq WP_001215861 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAA79817.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO 0000305}; # eggNOG ENOG4108SKK Bacteria # eggNOG ENOG41108CS LUCA BLAST swissprot:YFHG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YFHG_ECOLI BioCyc ECOL316407:JW2539-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2539-MONOMER BioCyc EcoCyc:EG12139-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12139-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.M610507200 http://dx.doi.org/10.1074/jbc.M610507200 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL S67014 http://www.ebi.ac.uk/ena/data/view/S67014 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U36841 http://www.ebi.ac.uk/ena/data/view/U36841 EchoBASE EB2060 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2060 EcoGene EG12139 http://www.ecogene.org/geneInfo.php?eg_id=EG12139 EnsemblBacteria AAC75608 http://www.ensemblgenomes.org/id/AAC75608 EnsemblBacteria AAC75608 http://www.ensemblgenomes.org/id/AAC75608 EnsemblBacteria BAA16463 http://www.ensemblgenomes.org/id/BAA16463 EnsemblBacteria BAA16463 http://www.ensemblgenomes.org/id/BAA16463 EnsemblBacteria BAA16463 http://www.ensemblgenomes.org/id/BAA16463 EnsemblBacteria b2555 http://www.ensemblgenomes.org/id/b2555 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 947010 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947010 HOGENOM HOG000123524 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000123524&db=HOGENOM6 InterPro IPR025262 http://www.ebi.ac.uk/interpro/entry/IPR025262 KEGG_Gene ecj:JW2539 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2539 KEGG_Gene eco:b2555 http://www.genome.jp/dbget-bin/www_bget?eco:b2555 OMA AMNNALY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AMNNALY PSORT swissprot:YFHG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YFHG_ECOLI PSORT-B swissprot:YFHG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YFHG_ECOLI PSORT2 swissprot:YFHG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YFHG_ECOLI Pfam PF13942 http://pfam.xfam.org/family/PF13942 Phobius swissprot:YFHG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YFHG_ECOLI ProteinModelPortal P0AD44 http://www.proteinmodelportal.org/query/uniprot/P0AD44 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17218314 http://www.ncbi.nlm.nih.gov/pubmed/17218314 PubMed 8226691 http://www.ncbi.nlm.nih.gov/pubmed/8226691 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417050 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417050 RefSeq WP_001215861 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001215861 SMR P0AD44 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AD44 STRING 511145.b2555 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2555&targetmode=cogs UniProtKB YFHG_ECOLI http://www.uniprot.org/uniprot/YFHG_ECOLI UniProtKB-AC P0AD44 http://www.uniprot.org/uniprot/P0AD44 charge swissprot:YFHG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YFHG_ECOLI eggNOG ENOG4108SKK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108SKK eggNOG ENOG41108CS http://eggnogapi.embl.de/nog_data/html/tree/ENOG41108CS epestfind swissprot:YFHG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YFHG_ECOLI garnier swissprot:YFHG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YFHG_ECOLI helixturnhelix swissprot:YFHG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YFHG_ECOLI hmoment swissprot:YFHG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YFHG_ECOLI iep swissprot:YFHG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YFHG_ECOLI inforesidue swissprot:YFHG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YFHG_ECOLI octanol swissprot:YFHG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YFHG_ECOLI pepcoil swissprot:YFHG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YFHG_ECOLI pepdigest swissprot:YFHG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YFHG_ECOLI pepinfo swissprot:YFHG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YFHG_ECOLI pepnet swissprot:YFHG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YFHG_ECOLI pepstats swissprot:YFHG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YFHG_ECOLI pepwheel swissprot:YFHG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YFHG_ECOLI pepwindow swissprot:YFHG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YFHG_ECOLI sigcleave swissprot:YFHG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YFHG_ECOLI ## Database ID URL or Descriptions # AltName SURA_ECOLI Peptidyl-prolyl cis-trans isomerase SurA # AltName SURA_ECOLI Rotamase SurA # AltName SURA_ECOLI Survival protein A # BioGrid 4261014 312 # CATALYTIC ACTIVITY SURA_ECOLI Peptidylproline (omega=180) = peptidylproline (omega=0). # DOMAIN SURA_ECOLI The PPIase activity resides only in the second parvulin domain. The N-terminal region and the C-terminal tail are necessary and sufficient for the chaperone activity of SurA. The PPIase activity is dispensable for SurA function as a SurA protein with a deletion of the parvulin domains is almost completely functional in vivo. The N-terminal region and the C-terminal tail are also required for porin recognition. {ECO 0000269|PubMed 11226178}. # EcoGene EG10985 surA # FUNCTION SURA_ECOLI Chaperone involved in the correct folding and assembly of outer membrane proteins, such as OmpA, OmpF and LamB. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation. Essential for the survival of E.coli in stationary phase. Required for pilus biogenesis. {ECO 0000269|PubMed 16267292, ECO 0000269|PubMed 2165476, ECO 0000269|PubMed 8985185}. # GO_component GO:0030288 outer membrane-bounded periplasmic space; IDA:EcoCyc. # GO_function GO:0003755 peptidyl-prolyl cis-trans isomerase activity; IDA:EcoCyc. # GO_function GO:0042277 peptide binding; IDA:EcoCyc. # GO_function GO:0051082 unfolded protein binding; IPI:EcoCyc. # GO_process GO:0006457 protein folding; IMP:EcoCyc. # GO_process GO:0015031 protein transport; IEA:InterPro. # GO_process GO:0043165 Gram-negative-bacterium-type cell outer membrane assembly; IMP:EcoliWiki. # GO_process GO:0044010 single-species biofilm formation; IMP:EcoCyc. # GO_process GO:0050821 protein stabilization; IMP:CACAO. # GO_process GO:0051085 chaperone mediated protein folding requiring cofactor; IMP:EcoCyc. # GO_process GO:0060274 maintenance of stationary phase; IMP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0051082 unfolded protein binding # GOslim_process GO:0006457 protein folding # GOslim_process GO:0006810 transport # GOslim_process GO:0008150 biological_process # GOslim_process GO:0022607 cellular component assembly # GOslim_process GO:0042592 homeostatic process # GOslim_process GO:0061024 membrane organization # Gene3D 1.10.3120.10 -; 1. # HAMAP MF_01183 Chaperone_SurA # INTERACTION SURA_ECOLI P77774 bamB; NbExp=2; IntAct=EBI-558651, EBI-907297; # IntAct P0ABZ6 10 # InterPro IPR000297 PPIase_PpiC # InterPro IPR008880 Trigger_fac_C # InterPro IPR015391 SurA_N # InterPro IPR023034 PPIase_SurA # InterPro IPR023058 PPIase_PpiC_CS # InterPro IPR027304 Trigger_fact/SurA_dom # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03110 Chaperones and folding catalysts # Organism SURA_ECOLI Escherichia coli (strain K12) # PATRIC 32115205 VBIEscCol129921_0054 # PDB 1M5Y X-ray; 3.00 A; A/B/C/D=21-428 # PDB 2PV1 X-ray; 1.30 A; A=172-274 # PDB 2PV2 X-ray; 1.30 A; A/B/C/D=172-274 # PDB 2PV3 X-ray; 3.39 A; A/B=21-428 # PIR E64726 E64726 # PROSITE PS01096 PPIC_PPIASE_1; 2 # PROSITE PS50198 PPIC_PPIASE_2; 2 # Pfam PF00639 Rotamase # Pfam PF09312 SurA_N # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName SURA_ECOLI Chaperone SurA # RefSeq NP_414595 NC_000913.3 # RefSeq WP_000800457 NZ_LN832404.1 # SIMILARITY Contains 2 PpiC domains. {ECO 0000305}. # SUBCELLULAR LOCATION SURA_ECOLI Periplasm. Note=Is capable of associating with the outer membrane. # SUPFAM SSF109998 SSF109998 # eggNOG COG0760 LUCA # eggNOG ENOG4105DBD Bacteria BLAST swissprot:SURA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:SURA_ECOLI BioCyc ECOL316407:JW0052-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0052-MONOMER BioCyc EcoCyc:EG10985-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10985-MONOMER BioCyc MetaCyc:EG10985-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10985-MONOMER COG COG0760 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0760 DIP DIP-35827N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35827N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1998.1726 http://dx.doi.org/10.1006/jmbi.1998.1726 DOI 10.1016/S0969-2126(02)00877-8 http://dx.doi.org/10.1016/S0969-2126(02)00877-8 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1996.561412.x http://dx.doi.org/10.1046/j.1365-2958.1996.561412.x DOI 10.1074/jbc.M308853200 http://dx.doi.org/10.1074/jbc.M308853200 DOI 10.1074/jbc.M413742200 http://dx.doi.org/10.1074/jbc.M413742200 DOI 10.1093/emboj/20.1.285 http://dx.doi.org/10.1093/emboj/20.1.285 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1101/gad.10.24.3170 http://dx.doi.org/10.1101/gad.10.24.3170 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.187.22.7680-7686.2005 http://dx.doi.org/10.1128/JB.187.22.7680-7686.2005 EC_number EC:5.2.1.8 http://www.genome.jp/dbget-bin/www_bget?EC:5.2.1.8 EMBL AB013134 http://www.ebi.ac.uk/ena/data/view/AB013134 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M68521 http://www.ebi.ac.uk/ena/data/view/M68521 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 5.2.1.8 http://enzyme.expasy.org/EC/5.2.1.8 EchoBASE EB0978 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0978 EcoGene EG10985 http://www.ecogene.org/geneInfo.php?eg_id=EG10985 EnsemblBacteria AAC73164 http://www.ensemblgenomes.org/id/AAC73164 EnsemblBacteria AAC73164 http://www.ensemblgenomes.org/id/AAC73164 EnsemblBacteria BAB96620 http://www.ensemblgenomes.org/id/BAB96620 EnsemblBacteria BAB96620 http://www.ensemblgenomes.org/id/BAB96620 EnsemblBacteria BAB96620 http://www.ensemblgenomes.org/id/BAB96620 EnsemblBacteria b0053 http://www.ensemblgenomes.org/id/b0053 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0030288 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030288 GO_function GO:0003755 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003755 GO_function GO:0042277 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042277 GO_function GO:0051082 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051082 GO_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GO_process GO:0015031 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015031 GO_process GO:0043165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043165 GO_process GO:0044010 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044010 GO_process GO:0050821 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050821 GO_process GO:0051085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051085 GO_process GO:0060274 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060274 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0051082 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051082 GOslim_process GO:0006457 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006457 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0022607 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022607 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 GOslim_process GO:0061024 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0061024 Gene3D 1.10.3120.10 http://www.cathdb.info/version/latest/superfamily/1.10.3120.10 GeneID 944812 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944812 HAMAP MF_01183 http://hamap.expasy.org/unirule/MF_01183 HOGENOM HOG000264337 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000264337&db=HOGENOM6 InParanoid P0ABZ6 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABZ6 IntAct P0ABZ6 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABZ6* IntEnz 5.2.1.8 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.2.1.8 InterPro IPR000297 http://www.ebi.ac.uk/interpro/entry/IPR000297 InterPro IPR008880 http://www.ebi.ac.uk/interpro/entry/IPR008880 InterPro IPR015391 http://www.ebi.ac.uk/interpro/entry/IPR015391 InterPro IPR023034 http://www.ebi.ac.uk/interpro/entry/IPR023034 InterPro IPR023058 http://www.ebi.ac.uk/interpro/entry/IPR023058 InterPro IPR027304 http://www.ebi.ac.uk/interpro/entry/IPR027304 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03110 http://www.genome.jp/dbget-bin/www_bget?ko03110 KEGG_Gene ecj:JW0052 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0052 KEGG_Gene eco:b0053 http://www.genome.jp/dbget-bin/www_bget?eco:b0053 KEGG_Orthology KO:K03771 http://www.genome.jp/dbget-bin/www_bget?KO:K03771 MINT MINT-1242178 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1242178 OMA FGVHLIQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FGVHLIQ PDB 1M5Y http://www.ebi.ac.uk/pdbe-srv/view/entry/1M5Y PDB 2PV1 http://www.ebi.ac.uk/pdbe-srv/view/entry/2PV1 PDB 2PV2 http://www.ebi.ac.uk/pdbe-srv/view/entry/2PV2 PDB 2PV3 http://www.ebi.ac.uk/pdbe-srv/view/entry/2PV3 PDBsum 1M5Y http://www.ebi.ac.uk/pdbsum/1M5Y PDBsum 2PV1 http://www.ebi.ac.uk/pdbsum/2PV1 PDBsum 2PV2 http://www.ebi.ac.uk/pdbsum/2PV2 PDBsum 2PV3 http://www.ebi.ac.uk/pdbsum/2PV3 PROSITE PS01096 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01096 PROSITE PS50198 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50198 PSORT swissprot:SURA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:SURA_ECOLI PSORT-B swissprot:SURA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:SURA_ECOLI PSORT2 swissprot:SURA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:SURA_ECOLI Pfam PF00639 http://pfam.xfam.org/family/PF00639 Pfam PF09312 http://pfam.xfam.org/family/PF09312 Phobius swissprot:SURA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:SURA_ECOLI PhylomeDB P0ABZ6 http://phylomedb.org/?seqid=P0ABZ6 ProteinModelPortal P0ABZ6 http://www.proteinmodelportal.org/query/uniprot/P0ABZ6 PubMed 11226178 http://www.ncbi.nlm.nih.gov/pubmed/11226178 PubMed 12429090 http://www.ncbi.nlm.nih.gov/pubmed/12429090 PubMed 14506253 http://www.ncbi.nlm.nih.gov/pubmed/14506253 PubMed 15840585 http://www.ncbi.nlm.nih.gov/pubmed/15840585 PubMed 16267292 http://www.ncbi.nlm.nih.gov/pubmed/16267292 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2165476 http://www.ncbi.nlm.nih.gov/pubmed/2165476 PubMed 2670894 http://www.ncbi.nlm.nih.gov/pubmed/2670894 PubMed 8626309 http://www.ncbi.nlm.nih.gov/pubmed/8626309 PubMed 8878048 http://www.ncbi.nlm.nih.gov/pubmed/8878048 PubMed 8985185 http://www.ncbi.nlm.nih.gov/pubmed/8985185 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 RefSeq NP_414595 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414595 RefSeq WP_000800457 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000800457 SMR P0ABZ6 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ABZ6 STRING 511145.b0053 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0053&targetmode=cogs STRING COG0760 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0760&targetmode=cogs SUPFAM SSF109998 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF109998 SWISS-2DPAGE P0ABZ6 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0ABZ6 UniProtKB SURA_ECOLI http://www.uniprot.org/uniprot/SURA_ECOLI UniProtKB-AC P0ABZ6 http://www.uniprot.org/uniprot/P0ABZ6 charge swissprot:SURA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:SURA_ECOLI eggNOG COG0760 http://eggnogapi.embl.de/nog_data/html/tree/COG0760 eggNOG ENOG4105DBD http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DBD epestfind swissprot:SURA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:SURA_ECOLI garnier swissprot:SURA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:SURA_ECOLI helixturnhelix swissprot:SURA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:SURA_ECOLI hmoment swissprot:SURA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:SURA_ECOLI iep swissprot:SURA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:SURA_ECOLI inforesidue swissprot:SURA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:SURA_ECOLI octanol swissprot:SURA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:SURA_ECOLI pepcoil swissprot:SURA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:SURA_ECOLI pepdigest swissprot:SURA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:SURA_ECOLI pepinfo swissprot:SURA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:SURA_ECOLI pepnet swissprot:SURA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:SURA_ECOLI pepstats swissprot:SURA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:SURA_ECOLI pepwheel swissprot:SURA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:SURA_ECOLI pepwindow swissprot:SURA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:SURA_ECOLI sigcleave swissprot:SURA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:SURA_ECOLI ## Database ID URL or Descriptions # AltName TDCE_ECOLI Keto-acid formate acetyltransferase # AltName TDCE_ECOLI Keto-acid formate-lyase # AltName TDCE_ECOLI Ketobutyrate formate-lyase # AltName TDCE_ECOLI Pyruvate formate-lyase # BioGrid 4262415 15 # CATALYTIC ACTIVITY TDCE_ECOLI Acetyl-CoA + formate = CoA + pyruvate. # CATALYTIC ACTIVITY TDCE_ECOLI Propionyl-CoA + formate = CoA + 2- oxobutanoate. # CDD cd01678 PFL1 # DISRUPTION PHENOTYPE No discernible phenotype. {ECO:0000269|PubMed 9484901}. # ENZYME REGULATION Dependent on PFL-activase. {ECO:0000269|PubMed 9484901}. # EcoGene EG12758 tdcE # FUNCTION TDCE_ECOLI Catalyzes the cleavage of 2-ketobutyrate to propionyl- CoA and formate. It can also use pyruvate as substrate. {ECO 0000269|PubMed 9484901}. # GO_component GO:0005737 cytoplasm; IDA:UniProtKB. # GO_component GO:0005829 cytosol; IBA:GO_Central. # GO_component GO:0016020 membrane; IDA:EcoliWiki. # GO_function GO:0008861 formate C-acetyltransferase activity; IDA:EcoCyc. # GO_function GO:0043875 2-ketobutyrate formate-lyase activity; IGI:EcoliWiki. # GO_process GO:0005975 carbohydrate metabolic process; IEA:InterPro. # GO_process GO:0006567 threonine catabolic process; IEP:EcoCyc. # GO_process GO:0070689 L-threonine catabolic process to propionate; IC:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016746 transferase activity, transferring acyl groups # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009056 catabolic process # INDUCTION Strongly repressed by glucose. Anaerobic growth of the pfl mutant in the presence of cAMP and L-threonine induced synthesis of TdcE. {ECO:0000269|PubMed 9484901}. # IntAct P42632 2 # InterPro IPR001150 Gly_radical # InterPro IPR004184 PFL_dom # InterPro IPR005949 Form_AcTrfase # InterPro IPR019777 Form_AcTrfase_GR_CS # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00620 Pyruvate metabolism # KEGG_Pathway ko00640 Propanoate metabolism # KEGG_Pathway ko00650 Butanoate metabolism # Organism TDCE_ECOLI Escherichia coli (strain K12) # PATHWAY Amino-acid degradation; L-threonine degradation via propanoate pathway; propanoate from L-threonine step 2/4. # PATRIC 32121644 VBIEscCol129921_3208 # PIR G65100 G65100 # PIRSF PIRSF000379 For_Ac_trans_1 # PROSITE PS00850 GLY_RADICAL_1 # PROSITE PS51149 GLY_RADICAL_2 # PROSITE PS51554 PFL # Pfam PF01228 Gly_radical # Pfam PF02901 PFL-like # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TDCE_ECOLI PFL-like enzyme TdcE # RefSeq WP_000861734 NZ_LN832404.1 # RefSeq YP_026205 NC_000913.3 # SEQUENCE CAUTION Sequence=AAA57918.1; Type=Frameshift; Positions=742; Evidence={ECO 0000305}; # SIMILARITY Contains 1 PFL domain. {ECO:0000255|PROSITE- ProRule PRU00887}. # SIMILARITY Contains 1 glycine radical domain. {ECO:0000255|PROSITE-ProRule PRU00493}. # SUBCELLULAR LOCATION TDCE_ECOLI Cytoplasm {ECO 0000250}. # TIGRFAMs TIGR01255 pyr_form_ly_1 # UniPathway UPA00052 UER00508 # eggNOG COG1882 LUCA # eggNOG ENOG4105C6N Bacteria BLAST swissprot:TDCE_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TDCE_ECOLI BioCyc ECOL316407:JW5522-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5522-MONOMER BioCyc EcoCyc:KETOBUTFORMLY-INACT-MONOMER http://biocyc.org/getid?id=EcoCyc:KETOBUTFORMLY-INACT-MONOMER BioCyc MetaCyc:KETOBUTFORMLY-INACT-MONOMER http://biocyc.org/getid?id=MetaCyc:KETOBUTFORMLY-INACT-MONOMER COG COG1882 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1882 DIP DIP-10972N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-10972N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1046/j.1365-2958.1998.00696.x http://dx.doi.org/10.1046/j.1365-2958.1998.00696.x DOI 10.1093/nar/gkj405 http://dx.doi.org/10.1093/nar/gkj405 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.3.1.- http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.- EC_number EC:2.3.1.54 http://www.genome.jp/dbget-bin/www_bget?EC:2.3.1.54 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 ENZYME 2.3.1.- http://enzyme.expasy.org/EC/2.3.1.- ENZYME 2.3.1.54 http://enzyme.expasy.org/EC/2.3.1.54 EchoBASE EB2612 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2612 EcoGene EG12758 http://www.ecogene.org/geneInfo.php?eg_id=EG12758 EnsemblBacteria AAT48170 http://www.ensemblgenomes.org/id/AAT48170 EnsemblBacteria AAT48170 http://www.ensemblgenomes.org/id/AAT48170 EnsemblBacteria BAE77162 http://www.ensemblgenomes.org/id/BAE77162 EnsemblBacteria BAE77162 http://www.ensemblgenomes.org/id/BAE77162 EnsemblBacteria BAE77162 http://www.ensemblgenomes.org/id/BAE77162 EnsemblBacteria b3114 http://www.ensemblgenomes.org/id/b3114 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0008861 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008861 GO_function GO:0043875 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043875 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GO_process GO:0006567 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006567 GO_process GO:0070689 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070689 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016746 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016746 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GeneID 947623 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947623 HOGENOM HOG000011346 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000011346&db=HOGENOM6 InParanoid P42632 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P42632 IntAct P42632 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P42632* IntEnz 2.3.1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1 IntEnz 2.3.1.54 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.3.1.54 InterPro IPR001150 http://www.ebi.ac.uk/interpro/entry/IPR001150 InterPro IPR004184 http://www.ebi.ac.uk/interpro/entry/IPR004184 InterPro IPR005949 http://www.ebi.ac.uk/interpro/entry/IPR005949 InterPro IPR019777 http://www.ebi.ac.uk/interpro/entry/IPR019777 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW5522 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5522 KEGG_Gene eco:b3114 http://www.genome.jp/dbget-bin/www_bget?eco:b3114 KEGG_Orthology KO:K00656 http://www.genome.jp/dbget-bin/www_bget?KO:K00656 KEGG_Pathway ko00620 http://www.genome.jp/kegg-bin/show_pathway?ko00620 KEGG_Pathway ko00640 http://www.genome.jp/kegg-bin/show_pathway?ko00640 KEGG_Pathway ko00650 http://www.genome.jp/kegg-bin/show_pathway?ko00650 KEGG_Reaction rn:R00212 http://www.genome.jp/dbget-bin/www_bget?rn:R00212 KEGG_Reaction rn:R06987 http://www.genome.jp/dbget-bin/www_bget?rn:R06987 MINT MINT-1231745 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1231745 OMA GIRQENA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GIRQENA PROSITE PS00850 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00850 PROSITE PS51149 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51149 PROSITE PS51554 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51554 PSORT swissprot:TDCE_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TDCE_ECOLI PSORT-B swissprot:TDCE_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TDCE_ECOLI PSORT2 swissprot:TDCE_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TDCE_ECOLI Pfam PF01228 http://pfam.xfam.org/family/PF01228 Pfam PF02901 http://pfam.xfam.org/family/PF02901 Phobius swissprot:TDCE_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TDCE_ECOLI PhylomeDB P42632 http://phylomedb.org/?seqid=P42632 ProteinModelPortal P42632 http://www.proteinmodelportal.org/query/uniprot/P42632 PubMed 16397293 http://www.ncbi.nlm.nih.gov/pubmed/16397293 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9484901 http://www.ncbi.nlm.nih.gov/pubmed/9484901 RefSeq WP_000861734 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000861734 RefSeq YP_026205 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_026205 SMR P42632 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P42632 STRING 511145.b3114 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3114&targetmode=cogs STRING COG1882 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1882&targetmode=cogs TIGRFAMs TIGR01255 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01255 UniProtKB TDCE_ECOLI http://www.uniprot.org/uniprot/TDCE_ECOLI UniProtKB-AC P42632 http://www.uniprot.org/uniprot/P42632 charge swissprot:TDCE_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TDCE_ECOLI eggNOG COG1882 http://eggnogapi.embl.de/nog_data/html/tree/COG1882 eggNOG ENOG4105C6N http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C6N epestfind swissprot:TDCE_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TDCE_ECOLI garnier swissprot:TDCE_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TDCE_ECOLI helixturnhelix swissprot:TDCE_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TDCE_ECOLI hmoment swissprot:TDCE_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TDCE_ECOLI iep swissprot:TDCE_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TDCE_ECOLI inforesidue swissprot:TDCE_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TDCE_ECOLI octanol swissprot:TDCE_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TDCE_ECOLI pepcoil swissprot:TDCE_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TDCE_ECOLI pepdigest swissprot:TDCE_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TDCE_ECOLI pepinfo swissprot:TDCE_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TDCE_ECOLI pepnet swissprot:TDCE_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TDCE_ECOLI pepstats swissprot:TDCE_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TDCE_ECOLI pepwheel swissprot:TDCE_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TDCE_ECOLI pepwindow swissprot:TDCE_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TDCE_ECOLI sigcleave swissprot:TDCE_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TDCE_ECOLI ## Database ID URL or Descriptions # AltName BIOC_ECOLI Biotin synthesis protein BioC # BRENDA 2.1.1.197 2026 # BioGrid 4259952 6 # CATALYTIC ACTIVITY S-adenosyl-L-methionine + malonyl-[acyl- carrier protein] = S-adenosyl-L-homocysteine + malonyl-[acyl- carrier protein] methyl ester. {ECO:0000269|PubMed 20693992}. # EcoGene EG10119 bioC # FUNCTION BIOC_ECOLI Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. E.coli employs a methylation and demethylation strategy to allow elongation of a temporarily disguised malonate moiety to a pimelate moiety by the fatty acid synthetic enzymes. {ECO 0000269|PubMed 20693992, ECO 0000269|PubMed 4864413}. # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0008757 S-adenosylmethionine-dependent methyltransferase activity; IBA:GO_Central. # GO_function GO:0010340 carboxyl-O-methyltransferase activity; IMP:EcoCyc. # GO_process GO:0009102 biotin biosynthetic process; IMP:EcoCyc. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0008168 methyltransferase activity # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # GOslim_process GO:0051186 cofactor metabolic process # Gene3D 3.40.50.150 -; 1. # HAMAP MF_00835 BioC # IntAct P12999 11 # InterPro IPR011814 BioC # InterPro IPR013216 Methyltransf_11 # InterPro IPR029063 SAM-dependent_MTases # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00780 Biotin metabolism # Organism BIOC_ECOLI Escherichia coli (strain K12) # PATHWAY BIOC_ECOLI Cofactor biosynthesis; biotin biosynthesis. # PATRIC 32116755 VBIEscCol129921_0803 # PIR A64814 BVECBC # Pfam PF08241 Methyltransf_11 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName BIOC_ECOLI Malonyl-[acyl-carrier protein] O-methyltransferase # RefSeq NP_415298 NC_000913.3 # RefSeq WP_000246761 NZ_LN832404.1 # SIMILARITY Belongs to the methyltransferase superfamily. {ECO 0000305}. # SUPFAM SSF53335 SSF53335 # TIGRFAMs TIGR02072 BioC # eggNOG COG0500 LUCA # eggNOG ENOG410626R Bacteria BLAST swissprot:BIOC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:BIOC_ECOLI BioCyc ECOL316407:JW0760-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0760-MONOMER BioCyc EcoCyc:EG10119-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10119-MONOMER BioCyc MetaCyc:EG10119-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10119-MONOMER COG COG0500 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0500 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nchembio.420 http://dx.doi.org/10.1038/nchembio.420 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.1.1.197 http://www.genome.jp/dbget-bin/www_bget?EC:2.1.1.197 EMBL A11534 http://www.ebi.ac.uk/ena/data/view/A11534 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J04423 http://www.ebi.ac.uk/ena/data/view/J04423 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.1.1.197 http://enzyme.expasy.org/EC/2.1.1.197 EchoBASE EB0117 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0117 EcoGene EG10119 http://www.ecogene.org/geneInfo.php?eg_id=EG10119 EnsemblBacteria AAC73864 http://www.ensemblgenomes.org/id/AAC73864 EnsemblBacteria AAC73864 http://www.ensemblgenomes.org/id/AAC73864 EnsemblBacteria BAE76364 http://www.ensemblgenomes.org/id/BAE76364 EnsemblBacteria BAE76364 http://www.ensemblgenomes.org/id/BAE76364 EnsemblBacteria BAE76364 http://www.ensemblgenomes.org/id/BAE76364 EnsemblBacteria b0777 http://www.ensemblgenomes.org/id/b0777 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0008757 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008757 GO_function GO:0010340 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010340 GO_process GO:0009102 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009102 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0008168 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008168 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 GOslim_process GO:0051186 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051186 Gene3D 3.40.50.150 http://www.cathdb.info/version/latest/superfamily/3.40.50.150 GeneID 945388 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945388 HAMAP MF_00835 http://hamap.expasy.org/unirule/MF_00835 HOGENOM HOG000265010 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000265010&db=HOGENOM6 InParanoid P12999 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P12999 IntAct P12999 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P12999* IntEnz 2.1.1.197 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.1.1.197 InterPro IPR011814 http://www.ebi.ac.uk/interpro/entry/IPR011814 InterPro IPR013216 http://www.ebi.ac.uk/interpro/entry/IPR013216 InterPro IPR029063 http://www.ebi.ac.uk/interpro/entry/IPR029063 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0760 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0760 KEGG_Gene eco:b0777 http://www.genome.jp/dbget-bin/www_bget?eco:b0777 KEGG_Orthology KO:K02169 http://www.genome.jp/dbget-bin/www_bget?KO:K02169 KEGG_Pathway ko00780 http://www.genome.jp/kegg-bin/show_pathway?ko00780 KEGG_Reaction rn:R09543 http://www.genome.jp/dbget-bin/www_bget?rn:R09543 OMA SHFRLEK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=SHFRLEK PSORT swissprot:BIOC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:BIOC_ECOLI PSORT-B swissprot:BIOC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:BIOC_ECOLI PSORT2 swissprot:BIOC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:BIOC_ECOLI Pfam PF08241 http://pfam.xfam.org/family/PF08241 Phobius swissprot:BIOC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:BIOC_ECOLI PhylomeDB P12999 http://phylomedb.org/?seqid=P12999 ProteinModelPortal P12999 http://www.proteinmodelportal.org/query/uniprot/P12999 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 20693992 http://www.ncbi.nlm.nih.gov/pubmed/20693992 PubMed 3058702 http://www.ncbi.nlm.nih.gov/pubmed/3058702 PubMed 4864413 http://www.ncbi.nlm.nih.gov/pubmed/4864413 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415298 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415298 RefSeq WP_000246761 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000246761 STRING 511145.b0777 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0777&targetmode=cogs STRING COG0500 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0500&targetmode=cogs SUPFAM SSF53335 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53335 TIGRFAMs TIGR02072 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02072 UniProtKB BIOC_ECOLI http://www.uniprot.org/uniprot/BIOC_ECOLI UniProtKB-AC P12999 http://www.uniprot.org/uniprot/P12999 charge swissprot:BIOC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:BIOC_ECOLI eggNOG COG0500 http://eggnogapi.embl.de/nog_data/html/tree/COG0500 eggNOG ENOG410626R http://eggnogapi.embl.de/nog_data/html/tree/ENOG410626R epestfind swissprot:BIOC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:BIOC_ECOLI garnier swissprot:BIOC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:BIOC_ECOLI helixturnhelix swissprot:BIOC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:BIOC_ECOLI hmoment swissprot:BIOC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:BIOC_ECOLI iep swissprot:BIOC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:BIOC_ECOLI inforesidue swissprot:BIOC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:BIOC_ECOLI octanol swissprot:BIOC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:BIOC_ECOLI pepcoil swissprot:BIOC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:BIOC_ECOLI pepdigest swissprot:BIOC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:BIOC_ECOLI pepinfo swissprot:BIOC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:BIOC_ECOLI pepnet swissprot:BIOC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:BIOC_ECOLI pepstats swissprot:BIOC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:BIOC_ECOLI pepwheel swissprot:BIOC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:BIOC_ECOLI pepwindow swissprot:BIOC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:BIOC_ECOLI sigcleave swissprot:BIOC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:BIOC_ECOLI ## Database ID URL or Descriptions # AltName TRUA_ECOLI tRNA pseudouridine(38-40) synthase # AltName TRUA_ECOLI tRNA pseudouridylate synthase I # AltName TRUA_ECOLI tRNA-uridine isomerase I # BioGrid 4261359 12 # CATALYTIC ACTIVITY tRNA uridine(38-40) = tRNA pseudouridine(38- 40). {ECO:0000269|PubMed 17466622}. # EcoGene EG10454 truA # FUNCTION TRUA_ECOLI Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. {ECO 0000269|PubMed 17466622}. # GO_function GO:0000049 tRNA binding; IDA:EcoCyc. # GO_function GO:0009982 pseudouridine synthase activity; IDA:EcoCyc. # GO_process GO:0031119 tRNA pseudouridine synthesis; IMP:EcoCyc. # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0006399 tRNA metabolic process # Gene3D 3.30.70.580 -; 1. # Gene3D 3.30.70.660 -; 1. # HAMAP MF_00171 TruA # IntAct P07649 9 # InterPro IPR001406 PsdUridine_synth_TruA # InterPro IPR020094 PsdUridine_synth_TruA_N # InterPro IPR020095 PsdUridine_synth_TruA_C # InterPro IPR020097 PsdUridine_synth_TruA_a/b_dom # InterPro IPR020103 PsdUridine_synth_cat_dom # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03016 Transfer RNA biogenesis # Organism TRUA_ECOLI Escherichia coli (strain K12) # PANTHER PTHR11142 PTHR11142 # PATRIC 32120007 VBIEscCol129921_2413 # PDB 1DJ0 X-ray; 1.50 A; A/B=7-270 # PDB 2NQP X-ray; 3.50 A; A/B/C/D=1-270 # PDB 2NR0 X-ray; 3.90 A; A/B/C/D=1-270 # PDB 2NRE X-ray; 4.00 A; A=1-270 # PIR B23792 SYECZ1 # PIRSF PIRSF001430 tRNA_psdUrid_synth # Pfam PF01416 PseudoU_synth_1; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName TRUA_ECOLI tRNA pseudouridine synthase A # RefSeq NP_416821 NC_000913.3 # RefSeq WP_001283586 NZ_LN832404.1 # SIMILARITY Belongs to the tRNA pseudouridine synthase TruA family. {ECO 0000305}. # SUBUNIT TRUA_ECOLI Homodimer. {ECO 0000269|PubMed 10625422, ECO 0000269|PubMed 17466622}. # SUPFAM SSF55120 SSF55120 # TIGRFAMs TIGR00071 hisT_truA # eggNOG COG0101 LUCA # eggNOG ENOG4105DI7 Bacteria BLAST swissprot:TRUA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:TRUA_ECOLI BioCyc ECOL316407:JW2315-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2315-MONOMER BioCyc EcoCyc:EG10454-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10454-MONOMER BioCyc MetaCyc:EG10454-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10454-MONOMER COG COG0101 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0101 DIP DIP-11043N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11043N DOI 10.1016/j.molcel.2007.02.027 http://dx.doi.org/10.1016/j.molcel.2007.02.027 DOI 10.1021/bi971874+ http://dx.doi.org/10.1021/bi971874+ DOI 10.1038/71219 http://dx.doi.org/10.1038/71219 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.96.25.14270 http://dx.doi.org/10.1073/pnas.96.25.14270 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1093/nar/13.14.5297 http://dx.doi.org/10.1093/nar/13.14.5297 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.4.99.12 http://www.genome.jp/dbget-bin/www_bget?EC:5.4.99.12 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M15542 http://www.ebi.ac.uk/ena/data/view/M15542 EMBL M15543 http://www.ebi.ac.uk/ena/data/view/M15543 EMBL M68934 http://www.ebi.ac.uk/ena/data/view/M68934 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X02743 http://www.ebi.ac.uk/ena/data/view/X02743 ENZYME 5.4.99.12 http://enzyme.expasy.org/EC/5.4.99.12 EchoBASE EB0449 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0449 EcoGene EG10454 http://www.ecogene.org/geneInfo.php?eg_id=EG10454 EnsemblBacteria AAC75378 http://www.ensemblgenomes.org/id/AAC75378 EnsemblBacteria AAC75378 http://www.ensemblgenomes.org/id/AAC75378 EnsemblBacteria BAA16175 http://www.ensemblgenomes.org/id/BAA16175 EnsemblBacteria BAA16175 http://www.ensemblgenomes.org/id/BAA16175 EnsemblBacteria BAA16175 http://www.ensemblgenomes.org/id/BAA16175 EnsemblBacteria b2318 http://www.ensemblgenomes.org/id/b2318 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0000049 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000049 GO_function GO:0009982 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009982 GO_process GO:0031119 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031119 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0006399 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006399 Gene3D 3.30.70.580 http://www.cathdb.info/version/latest/superfamily/3.30.70.580 Gene3D 3.30.70.660 http://www.cathdb.info/version/latest/superfamily/3.30.70.660 GeneID 946793 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946793 HAMAP MF_00171 http://hamap.expasy.org/unirule/MF_00171 HOGENOM HOG000248672 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000248672&db=HOGENOM6 InParanoid P07649 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P07649 IntAct P07649 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P07649* IntEnz 5.4.99.12 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.4.99.12 InterPro IPR001406 http://www.ebi.ac.uk/interpro/entry/IPR001406 InterPro IPR020094 http://www.ebi.ac.uk/interpro/entry/IPR020094 InterPro IPR020095 http://www.ebi.ac.uk/interpro/entry/IPR020095 InterPro IPR020097 http://www.ebi.ac.uk/interpro/entry/IPR020097 InterPro IPR020103 http://www.ebi.ac.uk/interpro/entry/IPR020103 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03016 http://www.genome.jp/dbget-bin/www_bget?ko03016 KEGG_Gene ecj:JW2315 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2315 KEGG_Gene eco:b2318 http://www.genome.jp/dbget-bin/www_bget?eco:b2318 KEGG_Orthology KO:K06173 http://www.genome.jp/dbget-bin/www_bget?KO:K06173 MINT MINT-1310146 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1310146 OMA PWRNVHH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PWRNVHH PANTHER PTHR11142 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11142 PDB 1DJ0 http://www.ebi.ac.uk/pdbe-srv/view/entry/1DJ0 PDB 2NQP http://www.ebi.ac.uk/pdbe-srv/view/entry/2NQP PDB 2NR0 http://www.ebi.ac.uk/pdbe-srv/view/entry/2NR0 PDB 2NRE http://www.ebi.ac.uk/pdbe-srv/view/entry/2NRE PDBsum 1DJ0 http://www.ebi.ac.uk/pdbsum/1DJ0 PDBsum 2NQP http://www.ebi.ac.uk/pdbsum/2NQP PDBsum 2NR0 http://www.ebi.ac.uk/pdbsum/2NR0 PDBsum 2NRE http://www.ebi.ac.uk/pdbsum/2NRE PSORT swissprot:TRUA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:TRUA_ECOLI PSORT-B swissprot:TRUA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:TRUA_ECOLI PSORT2 swissprot:TRUA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:TRUA_ECOLI Pfam PF01416 http://pfam.xfam.org/family/PF01416 Phobius swissprot:TRUA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:TRUA_ECOLI PhylomeDB P07649 http://phylomedb.org/?seqid=P07649 ProteinModelPortal P07649 http://www.proteinmodelportal.org/query/uniprot/P07649 PubMed 10588695 http://www.ncbi.nlm.nih.gov/pubmed/10588695 PubMed 10625422 http://www.ncbi.nlm.nih.gov/pubmed/10625422 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 17466622 http://www.ncbi.nlm.nih.gov/pubmed/17466622 PubMed 2991861 http://www.ncbi.nlm.nih.gov/pubmed/2991861 PubMed 3029016 http://www.ncbi.nlm.nih.gov/pubmed/3029016 PubMed 3040734 http://www.ncbi.nlm.nih.gov/pubmed/3040734 PubMed 3276686 http://www.ncbi.nlm.nih.gov/pubmed/3276686 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9425056 http://www.ncbi.nlm.nih.gov/pubmed/9425056 RefSeq NP_416821 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416821 RefSeq WP_001283586 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001283586 SMR P07649 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P07649 STRING 511145.b2318 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2318&targetmode=cogs STRING COG0101 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0101&targetmode=cogs SUPFAM SSF55120 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55120 TIGRFAMs TIGR00071 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00071 UniProtKB TRUA_ECOLI http://www.uniprot.org/uniprot/TRUA_ECOLI UniProtKB-AC P07649 http://www.uniprot.org/uniprot/P07649 charge swissprot:TRUA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:TRUA_ECOLI eggNOG COG0101 http://eggnogapi.embl.de/nog_data/html/tree/COG0101 eggNOG ENOG4105DI7 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105DI7 epestfind swissprot:TRUA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:TRUA_ECOLI garnier swissprot:TRUA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:TRUA_ECOLI helixturnhelix swissprot:TRUA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:TRUA_ECOLI hmoment swissprot:TRUA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:TRUA_ECOLI iep swissprot:TRUA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:TRUA_ECOLI inforesidue swissprot:TRUA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:TRUA_ECOLI octanol swissprot:TRUA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:TRUA_ECOLI pepcoil swissprot:TRUA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:TRUA_ECOLI pepdigest swissprot:TRUA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:TRUA_ECOLI pepinfo swissprot:TRUA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:TRUA_ECOLI pepnet swissprot:TRUA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:TRUA_ECOLI pepstats swissprot:TRUA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:TRUA_ECOLI pepwheel swissprot:TRUA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:TRUA_ECOLI pepwindow swissprot:TRUA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:TRUA_ECOLI sigcleave swissprot:TRUA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:TRUA_ECOLI ## Database ID URL or Descriptions # BioGrid 4262047 10 # CDD cd04451 S1_IF1 # EcoGene EG10504 infA # FUNCTION IF1_ECOLI One of the essential components for the initiation of protein synthesis. Binds in the vicinity of the A-site. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N- formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit, IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex. {ECO 0000269|PubMed 22562136, ECO 0000269|PubMed 376343}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003743 translation initiation factor activity; IEA:UniProtKB-HAMAP. # GO_function GO:0019843 rRNA binding; IEA:UniProtKB-HAMAP. # GO_function GO:0043022 ribosome binding; IDA:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0008135 translation factor activity, RNA binding # GOslim_function GO:0019843 rRNA binding # HAMAP MF_00075 IF_1 # INTERACTION IF1_ECOLI Q46864 mqsA; NbExp=2; IntAct=EBI-1120746, EBI-1120353; # IntAct P69222 10 # InterPro IPR004368 TIF_IF1 # InterPro IPR006196 RNA-binding_domain_S1_IF1 # InterPro IPR012340 NA-bd_OB-fold # InterPro IPR022967 S1_dom # KEGG_Brite ko03012 Translation factors # Organism IF1_ECOLI Escherichia coli (strain K12) # PATRIC 32116977 VBIEscCol129921_0913 # PDB 1AH9 NMR; -; A=2-72 # PDB 1ZO1 EM; 13.80 A; W=34-61 # PIR A27855 FIEC1 # PROSITE PS50832 S1_IF1_TYPE # Pfam PF01176 eIF-1a # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Translation initiation factor IF-1 {ECO:0000255|HAMAP-Rule MF_00075} # RefSeq NP_415404 NC_000913.3 # RefSeq WP_001040187 NZ_LN832404.1 # SIMILARITY Belongs to the IF-1 family. {ECO:0000255|HAMAP- Rule MF_00075}. # SIMILARITY Contains 1 S1-like domain. {ECO:0000255|HAMAP- Rule MF_00075}. # SMART SM00316 S1 # SUBCELLULAR LOCATION IF1_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00075, ECO 0000269|PubMed 376343}. # SUBUNIT IF1_ECOLI Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly. {ECO 0000255|HAMAP- Rule MF_00075, ECO 0000269|PubMed 21750663, ECO 0000269|PubMed 22562136}. # SUPFAM SSF50249 SSF50249 # TIGRFAMs TIGR00008 infA # eggNOG COG0361 LUCA BLAST swissprot:IF1_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:IF1_ECOLI BioCyc ECOL316407:JW0867-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0867-MONOMER BioCyc EcoCyc:EG10504-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10504-MONOMER COG COG0361 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0361 DIP DIP-48250N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-48250N DOI 10.1016/0014-5793(79)81316-2 http://dx.doi.org/10.1016/0014-5793(79)81316-2 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1038/nsmb.2285 http://dx.doi.org/10.1038/nsmb.2285 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1093/emboj/16.6.1436 http://dx.doi.org/10.1093/emboj/16.6.1436 DOI 10.1093/nar/15.13.5157 http://dx.doi.org/10.1093/nar/15.13.5157 DOI 10.1111/j.1574-6968.1998.tb13343.x http://dx.doi.org/10.1111/j.1574-6968.1998.tb13343.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1371/journal.pbio.1001095 http://dx.doi.org/10.1371/journal.pbio.1001095 DOI 10.3109/10409238.2012.678284 http://dx.doi.org/10.3109/10409238.2012.678284 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L10383 http://www.ebi.ac.uk/ena/data/view/L10383 EMBL M63145 http://www.ebi.ac.uk/ena/data/view/M63145 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL Y00373 http://www.ebi.ac.uk/ena/data/view/Y00373 EchoBASE EB0499 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0499 EcoGene EG10504 http://www.ecogene.org/geneInfo.php?eg_id=EG10504 EnsemblBacteria AAC73970 http://www.ensemblgenomes.org/id/AAC73970 EnsemblBacteria AAC73970 http://www.ensemblgenomes.org/id/AAC73970 EnsemblBacteria BAA35602 http://www.ensemblgenomes.org/id/BAA35602 EnsemblBacteria BAA35602 http://www.ensemblgenomes.org/id/BAA35602 EnsemblBacteria BAA35602 http://www.ensemblgenomes.org/id/BAA35602 EnsemblBacteria b0884 http://www.ensemblgenomes.org/id/b0884 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003743 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003743 GO_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GO_function GO:0043022 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043022 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0008135 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008135 GOslim_function GO:0019843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019843 GeneID 5552070 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5552070 GeneID 945500 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945500 HAMAP MF_00075 http://hamap.expasy.org/unirule/MF_00075 HOGENOM HOG000221323 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000221323&db=HOGENOM6 InParanoid P69222 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P69222 IntAct P69222 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69222* InterPro IPR004368 http://www.ebi.ac.uk/interpro/entry/IPR004368 InterPro IPR006196 http://www.ebi.ac.uk/interpro/entry/IPR006196 InterPro IPR012340 http://www.ebi.ac.uk/interpro/entry/IPR012340 InterPro IPR022967 http://www.ebi.ac.uk/interpro/entry/IPR022967 KEGG_Brite ko03012 http://www.genome.jp/dbget-bin/www_bget?ko03012 KEGG_Gene ecj:JW0867 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0867 KEGG_Gene eco:b0884 http://www.genome.jp/dbget-bin/www_bget?eco:b0884 KEGG_Orthology KO:K02518 http://www.genome.jp/dbget-bin/www_bget?KO:K02518 OMA KGRIIWR http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KGRIIWR PDB 1AH9 http://www.ebi.ac.uk/pdbe-srv/view/entry/1AH9 PDB 1ZO1 http://www.ebi.ac.uk/pdbe-srv/view/entry/1ZO1 PDBsum 1AH9 http://www.ebi.ac.uk/pdbsum/1AH9 PDBsum 1ZO1 http://www.ebi.ac.uk/pdbsum/1ZO1 PROSITE PS50832 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50832 PSORT swissprot:IF1_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:IF1_ECOLI PSORT-B swissprot:IF1_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:IF1_ECOLI PSORT2 swissprot:IF1_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:IF1_ECOLI Pfam PF01176 http://pfam.xfam.org/family/PF01176 Phobius swissprot:IF1_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:IF1_ECOLI PhylomeDB P69222 http://phylomedb.org/?seqid=P69222 ProteinModelPortal P69222 http://www.proteinmodelportal.org/query/uniprot/P69222 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1909328 http://www.ncbi.nlm.nih.gov/pubmed/1909328 PubMed 21750663 http://www.ncbi.nlm.nih.gov/pubmed/21750663 PubMed 22515367 http://www.ncbi.nlm.nih.gov/pubmed/22515367 PubMed 22562136 http://www.ncbi.nlm.nih.gov/pubmed/22562136 PubMed 3037488 http://www.ncbi.nlm.nih.gov/pubmed/3037488 PubMed 376343 http://www.ncbi.nlm.nih.gov/pubmed/376343 PubMed 8331068 http://www.ncbi.nlm.nih.gov/pubmed/8331068 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9135158 http://www.ncbi.nlm.nih.gov/pubmed/9135158 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9868784 http://www.ncbi.nlm.nih.gov/pubmed/9868784 RefSeq NP_415404 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415404 RefSeq WP_001040187 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001040187 SMART SM00316 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00316 SMR P69222 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69222 STRING 511145.b0884 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0884&targetmode=cogs STRING COG0361 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0361&targetmode=cogs SUPFAM SSF50249 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50249 TIGRFAMs TIGR00008 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00008 UniProtKB IF1_ECOLI http://www.uniprot.org/uniprot/IF1_ECOLI UniProtKB-AC P69222 http://www.uniprot.org/uniprot/P69222 charge swissprot:IF1_ECOLI http://rest.g-language.org/emboss/charge/swissprot:IF1_ECOLI eggNOG COG0361 http://eggnogapi.embl.de/nog_data/html/tree/COG0361 epestfind swissprot:IF1_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:IF1_ECOLI garnier swissprot:IF1_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:IF1_ECOLI helixturnhelix swissprot:IF1_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:IF1_ECOLI hmoment swissprot:IF1_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:IF1_ECOLI iep swissprot:IF1_ECOLI http://rest.g-language.org/emboss/iep/swissprot:IF1_ECOLI inforesidue swissprot:IF1_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:IF1_ECOLI octanol swissprot:IF1_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:IF1_ECOLI pepcoil swissprot:IF1_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:IF1_ECOLI pepdigest swissprot:IF1_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:IF1_ECOLI pepinfo swissprot:IF1_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:IF1_ECOLI pepnet swissprot:IF1_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:IF1_ECOLI pepstats swissprot:IF1_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:IF1_ECOLI pepwheel swissprot:IF1_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:IF1_ECOLI pepwindow swissprot:IF1_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:IF1_ECOLI sigcleave swissprot:IF1_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:IF1_ECOLI ## Database ID URL or Descriptions # AltName FUCI_ECOLI 6-deoxy-L-galactose isomerase # AltName FUCI_ECOLI D-arabinose isomerase # BIOPHYSICOCHEMICAL PROPERTIES Kinetic parameters KM=17 mM for L-fucose; KM=35 mM for D-arabinose; KM=1.4 mM for L-fuculose; KM=11 mM for D-ribulose; # BioGrid 4259466 6 # CATALYTIC ACTIVITY D-arabinose = D-ribulose. {ECO:0000269|PubMed 9367760}. # CATALYTIC ACTIVITY L-fucopyranose = L-fuculose. {ECO:0000269|PubMed 9367760}. # COFACTOR Name=Mn(2+); Xref=ChEBI:CHEBI 29035; # EcoGene EG10349 fucI # FUNCTION FUCI_ECOLI Converts the aldose L-fucose into the corresponding ketose L-fuculose. Is also able to convert D-arabinose into D- ribulose, but this isomerase has a higher affinity for fucose and fuculose than for arabinose and ribulose, respectively. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_function GO:0008736 L-fucose isomerase activity; IDA:EcoCyc. # GO_function GO:0008790 arabinose isomerase activity; IDA:EcoCyc. # GO_function GO:0030145 manganese ion binding; IEA:UniProtKB-HAMAP. # GO_process GO:0019571 D-arabinose catabolic process; IMP:EcoCyc. # GO_process GO:0042355 L-fucose catabolic process; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016853 isomerase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0009056 catabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.20.14.10 -; 1. # Gene3D 3.40.275.10 -; 1. # Gene3D 3.40.50.1070 -; 1. # HAMAP MF_01254 Fucose_iso # INDUCTION FUCI_ECOLI By L-fucose. # INTERACTION FUCI_ECOLI Self; NbExp=2; IntAct=EBI-908978, EBI-908978; # IntAct P69922 2 # InterPro IPR004216 Fuc/Ara_isomerase_C # InterPro IPR005763 Fucose_isomerase # InterPro IPR009015 Fucose_isomerase_N/cen # InterPro IPR012888 Fucose_iso_N1 # InterPro IPR012889 Fucose_isomerase_N2 # InterPro IPR015888 Fuc_isomerase_C # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00051 Fructose and mannose metabolism # Organism FUCI_ECOLI Escherichia coli (strain K12) # PATHWAY Carbohydrate degradation; L-fucose degradation; L- lactaldehyde and glycerone phosphate from L-fucose step 1/3. # PATRIC 32121020 VBIEscCol129921_2902 # PDB 1FUI X-ray; 2.50 A; A/B/C/D/E/F=1-591 # PIR JS0185 ISECFI # Pfam PF02952 Fucose_iso_C # Pfam PF07881 Fucose_iso_N1 # Pfam PF07882 Fucose_iso_N2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FUCI_ECOLI L-fucose isomerase # RefSeq NP_417282 NC_000913.3 # RefSeq WP_000724153 NZ_LN832404.1 # SIMILARITY Belongs to the L-fucose isomerase family. {ECO 0000305}. # SUBCELLULAR LOCATION FUCI_ECOLI Cytoplasm. # SUBUNIT FUCI_ECOLI Homohexamer. # SUPFAM SSF50443 SSF50443 # SUPFAM SSF53743 SSF53743 # TIGRFAMs TIGR01089 fucI # UniPathway UPA00563 UER00624 # eggNOG COG2407 LUCA # eggNOG ENOG4105EHF Bacteria BLAST swissprot:FUCI_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FUCI_ECOLI BioCyc ECOL316407:JW2773-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2773-MONOMER BioCyc EcoCyc:FUCISOM-MONOMER http://biocyc.org/getid?id=EcoCyc:FUCISOM-MONOMER BioCyc MetaCyc:FUCISOM-MONOMER http://biocyc.org/getid?id=MetaCyc:FUCISOM-MONOMER COG COG2407 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG2407 DOI 10.1006/jmbi.1997.1280 http://dx.doi.org/10.1006/jmbi.1997.1280 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/17.12.4883 http://dx.doi.org/10.1093/nar/17.12.4883 DOI 10.1111/j.1365-2958.1994.tb01066.x http://dx.doi.org/10.1111/j.1365-2958.1994.tb01066.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.3.1.25 http://www.genome.jp/dbget-bin/www_bget?EC:5.3.1.25 EC_number EC:5.3.1.3 http://www.genome.jp/dbget-bin/www_bget?EC:5.3.1.3 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 EMBL X15025 http://www.ebi.ac.uk/ena/data/view/X15025 ENZYME 5.3.1.25 http://enzyme.expasy.org/EC/5.3.1.25 ENZYME 5.3.1.3 http://enzyme.expasy.org/EC/5.3.1.3 EchoBASE EB0345 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0345 EcoGene EG10349 http://www.ecogene.org/geneInfo.php?eg_id=EG10349 EnsemblBacteria AAC75844 http://www.ensemblgenomes.org/id/AAC75844 EnsemblBacteria AAC75844 http://www.ensemblgenomes.org/id/AAC75844 EnsemblBacteria BAE76874 http://www.ensemblgenomes.org/id/BAE76874 EnsemblBacteria BAE76874 http://www.ensemblgenomes.org/id/BAE76874 EnsemblBacteria BAE76874 http://www.ensemblgenomes.org/id/BAE76874 EnsemblBacteria b2802 http://www.ensemblgenomes.org/id/b2802 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0008736 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008736 GO_function GO:0008790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008790 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_process GO:0019571 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019571 GO_process GO:0042355 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042355 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0009056 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009056 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.20.14.10 http://www.cathdb.info/version/latest/superfamily/3.20.14.10 Gene3D 3.40.275.10 http://www.cathdb.info/version/latest/superfamily/3.40.275.10 Gene3D 3.40.50.1070 http://www.cathdb.info/version/latest/superfamily/3.40.50.1070 GeneID 946195 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946195 HAMAP MF_01254 http://hamap.expasy.org/unirule/MF_01254 HOGENOM HOG000249674 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000249674&db=HOGENOM6 InParanoid P69922 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P69922 IntAct P69922 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P69922* IntEnz 5.3.1.25 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.3.1.25 IntEnz 5.3.1.3 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.3.1.3 InterPro IPR004216 http://www.ebi.ac.uk/interpro/entry/IPR004216 InterPro IPR005763 http://www.ebi.ac.uk/interpro/entry/IPR005763 InterPro IPR009015 http://www.ebi.ac.uk/interpro/entry/IPR009015 InterPro IPR012888 http://www.ebi.ac.uk/interpro/entry/IPR012888 InterPro IPR012889 http://www.ebi.ac.uk/interpro/entry/IPR012889 InterPro IPR015888 http://www.ebi.ac.uk/interpro/entry/IPR015888 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2773 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2773 KEGG_Gene eco:b2802 http://www.genome.jp/dbget-bin/www_bget?eco:b2802 KEGG_Orthology KO:K01818 http://www.genome.jp/dbget-bin/www_bget?KO:K01818 KEGG_Pathway ko00051 http://www.genome.jp/kegg-bin/show_pathway?ko00051 KEGG_Reaction rn:R03163 http://www.genome.jp/dbget-bin/www_bget?rn:R03163 OMA GAISYGH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=GAISYGH PDB 1FUI http://www.ebi.ac.uk/pdbe-srv/view/entry/1FUI PDBsum 1FUI http://www.ebi.ac.uk/pdbsum/1FUI PSORT swissprot:FUCI_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FUCI_ECOLI PSORT-B swissprot:FUCI_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FUCI_ECOLI PSORT2 swissprot:FUCI_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FUCI_ECOLI Pfam PF02952 http://pfam.xfam.org/family/PF02952 Pfam PF07881 http://pfam.xfam.org/family/PF07881 Pfam PF07882 http://pfam.xfam.org/family/PF07882 Phobius swissprot:FUCI_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FUCI_ECOLI PhylomeDB P69922 http://phylomedb.org/?seqid=P69922 ProteinModelPortal P69922 http://www.proteinmodelportal.org/query/uniprot/P69922 PubMed 13319278 http://www.ncbi.nlm.nih.gov/pubmed/13319278 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2664711 http://www.ncbi.nlm.nih.gov/pubmed/2664711 PubMed 8052131 http://www.ncbi.nlm.nih.gov/pubmed/8052131 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9367760 http://www.ncbi.nlm.nih.gov/pubmed/9367760 RefSeq NP_417282 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417282 RefSeq WP_000724153 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000724153 SMR P69922 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P69922 STRING 511145.b2802 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2802&targetmode=cogs STRING COG2407 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG2407&targetmode=cogs SUPFAM SSF50443 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF50443 SUPFAM SSF53743 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53743 TIGRFAMs TIGR01089 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01089 UniProtKB FUCI_ECOLI http://www.uniprot.org/uniprot/FUCI_ECOLI UniProtKB-AC P69922 http://www.uniprot.org/uniprot/P69922 charge swissprot:FUCI_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FUCI_ECOLI eggNOG COG2407 http://eggnogapi.embl.de/nog_data/html/tree/COG2407 eggNOG ENOG4105EHF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105EHF epestfind swissprot:FUCI_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FUCI_ECOLI garnier swissprot:FUCI_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FUCI_ECOLI helixturnhelix swissprot:FUCI_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FUCI_ECOLI hmoment swissprot:FUCI_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FUCI_ECOLI iep swissprot:FUCI_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FUCI_ECOLI inforesidue swissprot:FUCI_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FUCI_ECOLI octanol swissprot:FUCI_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FUCI_ECOLI pepcoil swissprot:FUCI_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FUCI_ECOLI pepdigest swissprot:FUCI_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FUCI_ECOLI pepinfo swissprot:FUCI_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FUCI_ECOLI pepnet swissprot:FUCI_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FUCI_ECOLI pepstats swissprot:FUCI_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FUCI_ECOLI pepwheel swissprot:FUCI_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FUCI_ECOLI pepwindow swissprot:FUCI_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FUCI_ECOLI sigcleave swissprot:FUCI_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FUCI_ECOLI ## Database ID URL or Descriptions # BioGrid 4262443 13 # CDD cd07377 WHTH_GntR # EcoGene EG12817 nanR # FUNCTION NANR_ECOLI Transcriptional repressor of the nan operon that encodes proteins involved in sialic acid utilization. {ECO 0000255|HAMAP- Rule MF_01236, ECO 0000269|PubMed 9864311}. # GO_function GO:0003677 DNA binding; IDA:EcoCyc. # GO_function GO:0003700 transcription factor activity, sequence-specific DNA binding; IEA:UniProtKB-HAMAP. # GO_process GO:0006351 transcription, DNA-templated; IDA:EcoCyc. # GO_process GO:0045892 negative regulation of transcription, DNA-templated; IEA:UniProtKB-HAMAP. # GOslim_function GO:0001071 nucleic acid binding transcription factor activity # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 1.10.10.10 -; 1. # Gene3D 1.20.120.530 -; 1. # HAMAP MF_01236 HTH_NanR # InterPro IPR000524 Tscrpt_reg_HTH_GntR # InterPro IPR008920 TF_FadR/GntR_C # InterPro IPR011711 GntR_C # InterPro IPR011991 WHTH_DNA-bd_dom # InterPro IPR023730 Tscrpt_reg_NanR # Organism NANR_ECOLI Escherichia coli (strain K12) # PATRIC 32121876 VBIEscCol129921_3322 # PIR D65114 D65114 # PRINTS PR00035 HTHGNTR # PROSITE PS50949 HTH_GNTR # Pfam PF00392 GntR # Pfam PF07729 FCD # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName Transcriptional regulator NanR {ECO:0000255|HAMAP-Rule MF_01236} # RefSeq NP_417693 NC_000913.3 # RefSeq WP_000523845 NZ_LN832404.1 # SIMILARITY Contains 1 HTH gntR-type DNA-binding domain. {ECO:0000255|HAMAP-Rule MF_01236}. # SMART SM00345 HTH_GNTR # SMART SM00895 FCD # SUPFAM SSF46785 SSF46785 # SUPFAM SSF48008 SSF48008 # eggNOG COG2186 LUCA # eggNOG ENOG4108QBF Bacteria BLAST swissprot:NANR_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:NANR_ECOLI BioCyc ECOL316407:JW3195-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3195-MONOMER BioCyc EcoCyc:G7678-MONOMER http://biocyc.org/getid?id=EcoCyc:G7678-MONOMER DIP DIP-12284N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12284N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2668 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2668 EcoGene EG12817 http://www.ecogene.org/geneInfo.php?eg_id=EG12817 EnsemblBacteria AAC76258 http://www.ensemblgenomes.org/id/AAC76258 EnsemblBacteria AAC76258 http://www.ensemblgenomes.org/id/AAC76258 EnsemblBacteria BAE77269 http://www.ensemblgenomes.org/id/BAE77269 EnsemblBacteria BAE77269 http://www.ensemblgenomes.org/id/BAE77269 EnsemblBacteria BAE77269 http://www.ensemblgenomes.org/id/BAE77269 EnsemblBacteria b3226 http://www.ensemblgenomes.org/id/b3226 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003700 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003700 GO_process GO:0006351 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351 GO_process GO:0045892 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045892 GOslim_function GO:0001071 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001071 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 1.10.10.10 http://www.cathdb.info/version/latest/superfamily/1.10.10.10 Gene3D 1.20.120.530 http://www.cathdb.info/version/latest/superfamily/1.20.120.530 GeneID 945468 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945468 HAMAP MF_01236 http://hamap.expasy.org/unirule/MF_01236 HOGENOM HOG000273991 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000273991&db=HOGENOM6 InParanoid P0A8W0 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8W0 IntAct P0A8W0 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8W0* InterPro IPR000524 http://www.ebi.ac.uk/interpro/entry/IPR000524 InterPro IPR008920 http://www.ebi.ac.uk/interpro/entry/IPR008920 InterPro IPR011711 http://www.ebi.ac.uk/interpro/entry/IPR011711 InterPro IPR011991 http://www.ebi.ac.uk/interpro/entry/IPR011991 InterPro IPR023730 http://www.ebi.ac.uk/interpro/entry/IPR023730 KEGG_Gene ecj:JW3195 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3195 KEGG_Gene eco:b3226 http://www.genome.jp/dbget-bin/www_bget?eco:b3226 OMA KNARIFF http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KNARIFF PRINTS PR00035 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00035 PROSITE PS50949 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50949 PSORT swissprot:NANR_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:NANR_ECOLI PSORT-B swissprot:NANR_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:NANR_ECOLI PSORT2 swissprot:NANR_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:NANR_ECOLI Pfam PF00392 http://pfam.xfam.org/family/PF00392 Pfam PF07729 http://pfam.xfam.org/family/PF07729 Phobius swissprot:NANR_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:NANR_ECOLI PhylomeDB P0A8W0 http://phylomedb.org/?seqid=P0A8W0 ProteinModelPortal P0A8W0 http://www.proteinmodelportal.org/query/uniprot/P0A8W0 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9864311 http://www.ncbi.nlm.nih.gov/pubmed/9864311 RefSeq NP_417693 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417693 RefSeq WP_000523845 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000523845 SMART SM00345 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00345 SMART SM00895 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00895 SMR P0A8W0 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8W0 STRING 511145.b3226 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3226&targetmode=cogs SUPFAM SSF46785 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46785 SUPFAM SSF48008 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF48008 UniProtKB NANR_ECOLI http://www.uniprot.org/uniprot/NANR_ECOLI UniProtKB-AC P0A8W0 http://www.uniprot.org/uniprot/P0A8W0 charge swissprot:NANR_ECOLI http://rest.g-language.org/emboss/charge/swissprot:NANR_ECOLI eggNOG COG2186 http://eggnogapi.embl.de/nog_data/html/tree/COG2186 eggNOG ENOG4108QBF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108QBF epestfind swissprot:NANR_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:NANR_ECOLI garnier swissprot:NANR_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:NANR_ECOLI helixturnhelix swissprot:NANR_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:NANR_ECOLI hmoment swissprot:NANR_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:NANR_ECOLI iep swissprot:NANR_ECOLI http://rest.g-language.org/emboss/iep/swissprot:NANR_ECOLI inforesidue swissprot:NANR_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:NANR_ECOLI octanol swissprot:NANR_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:NANR_ECOLI pepcoil swissprot:NANR_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:NANR_ECOLI pepdigest swissprot:NANR_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:NANR_ECOLI pepinfo swissprot:NANR_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:NANR_ECOLI pepnet swissprot:NANR_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:NANR_ECOLI pepstats swissprot:NANR_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:NANR_ECOLI pepwheel swissprot:NANR_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:NANR_ECOLI pepwindow swissprot:NANR_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:NANR_ECOLI sigcleave swissprot:NANR_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:NANR_ECOLI ## Database ID URL or Descriptions # CAUTION Could be the product of a pseudogene. Lacks the C- terminal half of the catalytic domain found in other members of this family. This truncated polypeptide does not display phospho- alpha- or phospho-beta-glucosidase activity (PubMed:9209025). {ECO 0000305|PubMed:9209025}. # CAZy GH4 Glycoside Hydrolase Family 4 # EcoGene EG11708 glvG # GO_function GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro. # GO_function GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro. # GO_function GO:0046872 metal ion binding; IEA:UniProtKB-KW. # GO_process GO:0005975 carbohydrate metabolic process; IEA:InterPro. # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0016798 hydrolase activity, acting on glycosyl bonds # GOslim_function GO:0043167 ion binding # GOslim_process GO:0005975 carbohydrate metabolic process # Gene3D 3.40.50.720 -; 1. # Gene3D 3.90.110.10 -; 1. # IntAct P31450 6 # InterPro IPR001088 Glyco_hydro_4 # InterPro IPR015955 Lactate_DH/Glyco_Ohase_4_C # InterPro IPR016040 NAD(P)-bd_dom # InterPro IPR019802 GlycHydrolase_4_CS # MISCELLANEOUS GLVG_ECOLI The GlvG polypeptide of 212 residues cross-reacts with anti-body prepared against the full-length 6-phospho-alpha-D- glucosidase (MalH) from Fusobacterium mortiferum. # Organism GLVG_ECOLI Escherichia coli (strain K12) # PIR B65170 B65170 # PRINTS PR00732 GLHYDRLASE4 # PROSITE PS01324 GLYCOSYL_HYDROL_F4 # Pfam PF02056 Glyco_hydro_4 # Proteomes UP000000625 Chromosome # RecName GLVG_ECOLI Putative inactive 6-phospho-alpha-glucosidase # RefSeq WP_001311230 NZ_LN832404.1 # SIMILARITY Belongs to the glycosyl hydrolase 4 family. {ECO 0000305}. # SUPFAM SSF51735 SSF51735 # SUPFAM SSF56327 SSF56327 BLAST swissprot:GLVG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:GLVG_ECOLI BioCyc EcoCyc:EG11708-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11708-MONOMER DIP DIP-9813N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9813N DOI 10.1002/pro.5560030309 http://dx.doi.org/10.1002/pro.5560030309 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1659 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1659 EcoGene EG11708 http://www.ecogene.org/geneInfo.php?eg_id=EG11708 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0004553 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004553 GO_function GO:0016616 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016616 GO_function GO:0046872 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872 GO_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0016798 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016798 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 Gene3D 3.40.50.720 http://www.cathdb.info/version/latest/superfamily/3.40.50.720 Gene3D 3.90.110.10 http://www.cathdb.info/version/latest/superfamily/3.90.110.10 HOGENOM HOG000202516 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000202516&db=HOGENOM6 IntAct P31450 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P31450* InterPro IPR001088 http://www.ebi.ac.uk/interpro/entry/IPR001088 InterPro IPR015955 http://www.ebi.ac.uk/interpro/entry/IPR015955 InterPro IPR016040 http://www.ebi.ac.uk/interpro/entry/IPR016040 InterPro IPR019802 http://www.ebi.ac.uk/interpro/entry/IPR019802 OMA MITEAVY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=MITEAVY PRINTS PR00732 http://umber.sbs.man.ac.uk/cgi-bin/dbbrowser/sprint/searchprintss.cgi?display_opts=Prints&category=None&queryform=false&prints_accn=PR00732 PROSITE PS01324 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01324 PSORT swissprot:GLVG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:GLVG_ECOLI PSORT-B swissprot:GLVG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:GLVG_ECOLI PSORT2 swissprot:GLVG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:GLVG_ECOLI Pfam PF02056 http://pfam.xfam.org/family/PF02056 Phobius swissprot:GLVG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:GLVG_ECOLI PhylomeDB P31450 http://phylomedb.org/?seqid=P31450 ProteinModelPortal P31450 http://www.proteinmodelportal.org/query/uniprot/P31450 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 8019415 http://www.ncbi.nlm.nih.gov/pubmed/8019415 PubMed 9209025 http://www.ncbi.nlm.nih.gov/pubmed/9209025 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001311230 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001311230 SMR P31450 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P31450 SUPFAM SSF51735 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF51735 SUPFAM SSF56327 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56327 UniProtKB GLVG_ECOLI http://www.uniprot.org/uniprot/GLVG_ECOLI UniProtKB-AC P31450 http://www.uniprot.org/uniprot/P31450 charge swissprot:GLVG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:GLVG_ECOLI epestfind swissprot:GLVG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:GLVG_ECOLI garnier swissprot:GLVG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:GLVG_ECOLI helixturnhelix swissprot:GLVG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:GLVG_ECOLI hmoment swissprot:GLVG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:GLVG_ECOLI iep swissprot:GLVG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:GLVG_ECOLI inforesidue swissprot:GLVG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:GLVG_ECOLI octanol swissprot:GLVG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:GLVG_ECOLI pepcoil swissprot:GLVG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:GLVG_ECOLI pepdigest swissprot:GLVG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:GLVG_ECOLI pepinfo swissprot:GLVG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:GLVG_ECOLI pepnet swissprot:GLVG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:GLVG_ECOLI pepstats swissprot:GLVG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:GLVG_ECOLI pepwheel swissprot:GLVG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:GLVG_ECOLI pepwindow swissprot:GLVG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:GLVG_ECOLI sigcleave swissprot:GLVG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:GLVG_ECOLI ## Database ID URL or Descriptions # AltName AHPC_ECOLI Alkyl hydroperoxide reductase protein C22 # AltName AHPC_ECOLI Peroxiredoxin # AltName AHPC_ECOLI SCRP-23 # AltName AHPC_ECOLI Sulfate starvation-induced protein 8 # AltName AHPC_ECOLI Thioredoxin peroxidase # BRENDA 1.11.1.15 2026 # BioGrid 4259893 12 # CATALYTIC ACTIVITY AHPC_ECOLI 2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH. # DISRUPTION PHENOTYPE Increased sensitivity to hydroxyurea, probably because more reactive oxygen species accumulate. {ECO:0000269|PubMed 20005847}. # EcoGene EG11384 ahpC # FUNCTION AHPC_ECOLI Directly reduces organic hydroperoxides in its reduced dithiol form. # GO_component GO:0005737 cytoplasm; IDA:EcoliWiki. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0009321 alkyl hydroperoxide reductase complex; IDA:EcoCyc. # GO_component GO:0016020 membrane; IDA:UniProtKB. # GO_function GO:0004601 peroxidase activity; IGI:EcoliWiki. # GO_function GO:0016684 oxidoreductase activity, acting on peroxide as acceptor; IMP:EcoliWiki. # GO_function GO:0032843 hydroperoxide reductase activity; IDA:EcoliWiki. # GO_function GO:0051920 peroxiredoxin activity; IEA:UniProtKB-EC. # GO_process GO:0009970 cellular response to sulfate starvation; IDA:EcoliWiki. # GO_process GO:0033194 response to hydroperoxide; IMP:EcoCyc. # GO_process GO:0033195 response to alkyl hydroperoxide; IMP:EcoCyc. # GO_process GO:0033214 iron assimilation by chelation and transport; IMP:CACAO. # GO_process GO:0045454 cell redox homeostasis; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005737 cytoplasm # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016491 oxidoreductase activity # GOslim_process GO:0006950 response to stress # GOslim_process GO:0042592 homeostatic process # Gene3D 3.40.30.10 -; 1. # INDUCTION AHPC_ECOLI Repressed by sulfate or cysteine. # INTERACTION AHPC_ECOLI Self; NbExp=2; IntAct=EBI-547397, EBI-547397; # IntAct P0AE08 33 # InterPro IPR000866 AhpC/TSA # InterPro IPR012336 Thioredoxin-like_fold # InterPro IPR013766 Thioredoxin_domain # InterPro IPR017559 AhpC # InterPro IPR019479 Peroxiredoxin_C # InterPro IPR024706 Peroxiredoxin_AhpC-typ # KEGG_Brite ko01000 Enzymes # Organism AHPC_ECOLI Escherichia coli (strain K12) # PATRIC 32116388 VBIEscCol129921_0634 # PIR C64794 JN0289 # PIRSF PIRSF000239 AHPC # PROSITE PS51352 THIOREDOXIN_2 # PTM AHPC_ECOLI The Cys-47-SH group is the primary site of oxidation by H(2)O(2), and the oxidized Cys-47 (probably Cys-SOH) rapidly reacts with Cys-166-SH of the other subunit to form an intermolecular disulfide. This disulfide is subsequently reduced by thioredoxin (By similarity). {ECO 0000250}. # PeroxiBase 4830 EcoAhpC # Pfam PF00578 AhpC-TSA # Pfam PF10417 1-cysPrx_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName AHPC_ECOLI Alkyl hydroperoxide reductase subunit C # RefSeq NP_415138 NC_000913.3 # RefSeq WP_000052796 NZ_LN832404.1 # SIMILARITY Belongs to the AhpC/TSA family. {ECO 0000305}. # SIMILARITY Contains 1 thioredoxin domain. {ECO:0000255|PROSITE- ProRule PRU00691}. # SUBUNIT Homodimer; disulfide-linked, upon oxidation. {ECO 0000250}. # SUPFAM SSF52833 SSF52833 # TIGRFAMs TIGR03137 AhpC # eggNOG COG0450 LUCA # eggNOG ENOG4105D3R Bacteria BLAST swissprot:AHPC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:AHPC_ECOLI BioCyc ECOL316407:JW0598-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0598-MONOMER BioCyc EcoCyc:EG11384-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11384-MONOMER BioCyc MetaCyc:EG11384-MONOMER http://biocyc.org/getid?id=MetaCyc:EG11384-MONOMER COG COG0450 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0450 DIP DIP-36164N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36164N DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1006/jmbi.1998.1726 http://dx.doi.org/10.1006/jmbi.1998.1726 DOI 10.1016/0006-291X(92)90636-Y http://dx.doi.org/10.1016/0006-291X(92)90636-Y DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.270.48.28635 http://dx.doi.org/10.1074/jbc.270.48.28635 DOI 10.1074/mcp.M800187-MCP200 http://dx.doi.org/10.1074/mcp.M800187-MCP200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1111/j.1432-1033.1996.0773u.x http://dx.doi.org/10.1111/j.1432-1033.1996.0773u.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.11.1.15 http://www.genome.jp/dbget-bin/www_bget?EC:1.11.1.15 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL D13187 http://www.ebi.ac.uk/ena/data/view/D13187 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 ENZYME 1.11.1.15 http://enzyme.expasy.org/EC/1.11.1.15 EchoBASE EB1357 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1357 EcoGene EG11384 http://www.ecogene.org/geneInfo.php?eg_id=EG11384 EnsemblBacteria AAC73706 http://www.ensemblgenomes.org/id/AAC73706 EnsemblBacteria AAC73706 http://www.ensemblgenomes.org/id/AAC73706 EnsemblBacteria BAA35235 http://www.ensemblgenomes.org/id/BAA35235 EnsemblBacteria BAA35235 http://www.ensemblgenomes.org/id/BAA35235 EnsemblBacteria BAA35235 http://www.ensemblgenomes.org/id/BAA35235 EnsemblBacteria b0605 http://www.ensemblgenomes.org/id/b0605 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0009321 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009321 GO_component GO:0016020 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020 GO_function GO:0004601 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004601 GO_function GO:0016684 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016684 GO_function GO:0032843 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032843 GO_function GO:0051920 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051920 GO_process GO:0009970 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009970 GO_process GO:0033194 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033194 GO_process GO:0033195 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033195 GO_process GO:0033214 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033214 GO_process GO:0045454 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045454 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GOslim_process GO:0042592 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042592 Gene3D 3.40.30.10 http://www.cathdb.info/version/latest/superfamily/3.40.30.10 GeneID 945225 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945225 HOGENOM HOG000022343 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000022343&db=HOGENOM6 InParanoid P0AE08 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AE08 IntAct P0AE08 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0AE08* IntEnz 1.11.1.15 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1.11.1.15 InterPro IPR000866 http://www.ebi.ac.uk/interpro/entry/IPR000866 InterPro IPR012336 http://www.ebi.ac.uk/interpro/entry/IPR012336 InterPro IPR013766 http://www.ebi.ac.uk/interpro/entry/IPR013766 InterPro IPR017559 http://www.ebi.ac.uk/interpro/entry/IPR017559 InterPro IPR019479 http://www.ebi.ac.uk/interpro/entry/IPR019479 InterPro IPR024706 http://www.ebi.ac.uk/interpro/entry/IPR024706 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0598 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0598 KEGG_Gene eco:b0605 http://www.genome.jp/dbget-bin/www_bget?eco:b0605 KEGG_Orthology KO:K03386 http://www.genome.jp/dbget-bin/www_bget?KO:K03386 MINT MINT-1241588 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1241588 OMA AWHETSE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AWHETSE PROSITE PS51352 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS51352 PSORT swissprot:AHPC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:AHPC_ECOLI PSORT-B swissprot:AHPC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:AHPC_ECOLI PSORT2 swissprot:AHPC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:AHPC_ECOLI PeroxiBase 4830 http://peroxibase.toulouse.inra.fr/listing.php?action=view&id=4830 Pfam PF00578 http://pfam.xfam.org/family/PF00578 Pfam PF10417 http://pfam.xfam.org/family/PF10417 Phobius swissprot:AHPC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:AHPC_ECOLI PhylomeDB P0AE08 http://phylomedb.org/?seqid=P0AE08 ProteinModelPortal P0AE08 http://www.proteinmodelportal.org/query/uniprot/P0AE08 PubMed 1575737 http://www.ncbi.nlm.nih.gov/pubmed/1575737 PubMed 1592833 http://www.ncbi.nlm.nih.gov/pubmed/1592833 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18723842 http://www.ncbi.nlm.nih.gov/pubmed/18723842 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 7499381 http://www.ncbi.nlm.nih.gov/pubmed/7499381 PubMed 8774726 http://www.ncbi.nlm.nih.gov/pubmed/8774726 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 PubMed 9600841 http://www.ncbi.nlm.nih.gov/pubmed/9600841 RefSeq NP_415138 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415138 RefSeq WP_000052796 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000052796 SMR P0AE08 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0AE08 STRING 511145.b0605 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0605&targetmode=cogs STRING COG0450 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0450&targetmode=cogs SUPFAM SSF52833 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52833 SWISS-2DPAGE P0AE08 http://world-2dpage.expasy.org/swiss-2dpage/protein/ac=P0AE08 TIGRFAMs TIGR03137 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR03137 UniProtKB AHPC_ECOLI http://www.uniprot.org/uniprot/AHPC_ECOLI UniProtKB-AC P0AE08 http://www.uniprot.org/uniprot/P0AE08 charge swissprot:AHPC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:AHPC_ECOLI eggNOG COG0450 http://eggnogapi.embl.de/nog_data/html/tree/COG0450 eggNOG ENOG4105D3R http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105D3R epestfind swissprot:AHPC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:AHPC_ECOLI garnier swissprot:AHPC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:AHPC_ECOLI helixturnhelix swissprot:AHPC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:AHPC_ECOLI hmoment swissprot:AHPC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:AHPC_ECOLI iep swissprot:AHPC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:AHPC_ECOLI inforesidue swissprot:AHPC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:AHPC_ECOLI octanol swissprot:AHPC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:AHPC_ECOLI pepcoil swissprot:AHPC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:AHPC_ECOLI pepdigest swissprot:AHPC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:AHPC_ECOLI pepinfo swissprot:AHPC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:AHPC_ECOLI pepnet swissprot:AHPC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:AHPC_ECOLI pepstats swissprot:AHPC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:AHPC_ECOLI pepwheel swissprot:AHPC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:AHPC_ECOLI pepwindow swissprot:AHPC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:AHPC_ECOLI sigcleave swissprot:AHPC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:AHPC_ECOLI ## Database ID URL or Descriptions # AltName DPO3B_ECOLI Beta sliding clamp # BioGrid 4259535 176 # CATALYTIC ACTIVITY DPO3B_ECOLI Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). # CDD cd00140 beta_clamp # EcoGene EG10242 dnaN # FUNCTION DPO3B_ECOLI DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication; once it is clamped onto DNA it slides freely (bidirectional and ATP- independent) along duplex DNA. Coordinates protein traffic at the replication fork, where it interacts with multiple DNA polymerases. {ECO 0000269|PubMed 15466025, ECO 0000269|PubMed 22716942}. # GO_component GO:0005829 cytosol; IDA:UniProtKB. # GO_component GO:0009360 DNA polymerase III complex; IEA:InterPro. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_function GO:0003887 DNA-directed DNA polymerase activity; IEA:UniProtKB-KW. # GO_function GO:0008408 3'-5' exonuclease activity; IEA:InterPro. # GO_function GO:0042802 identical protein binding; IPI:IntAct. # GO_process GO:0006271 DNA strand elongation involved in DNA replication; IDA:EcoCyc. # GO_process GO:0006974 cellular response to DNA damage stimulus; IEP:EcoliWiki. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_function GO:0004518 nuclease activity # GOslim_function GO:0016779 nucleotidyltransferase activity # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0006950 response to stress # INDUCTION Induced 1.5-fold by hydroxyurea. {ECO:0000269|PubMed 20005847}. # INTERACTION DPO3B_ECOLI Self; NbExp=9; IntAct=EBI-542385, EBI-542385; Q47155 dinB; NbExp=2; IntAct=EBI-542385, EBI-1037359; P10443 dnaE; NbExp=17; IntAct=EBI-542385, EBI-549111; P03007 dnaQ; NbExp=6; IntAct=EBI-542385, EBI-549131; P06710 dnaX; NbExp=4; IntAct=EBI-542385, EBI-549140; P69931 hda; NbExp=8; IntAct=EBI-542385, EBI-545453; P28630 holA; NbExp=10; IntAct=EBI-542385, EBI-549153; P0AG07 rpe; NbExp=3; IntAct=EBI-542385, EBI-546020; P05845 tnsE (xeno); NbExp=4; IntAct=EBI-542385, EBI-2434514; # IntAct P0A988 38 # InterPro IPR001001 DNA_polIII_beta # InterPro IPR022634 DNA_polIII_beta_N # InterPro IPR022635 DNA_polIII_beta_C # InterPro IPR022637 DNA_polIII_beta_cen # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03032 DNA replication proteins # KEGG_Brite ko03032 M00260 DNA polymerase III complex, bacteria # KEGG_Brite ko03400 DNA repair and recombination proteins # KEGG_Brite ko03400 M00260 DNA polymerase III complex, bacteria # KEGG_Pathway ko00230 Purine metabolism # KEGG_Pathway ko00240 Pyrimidine metabolism # KEGG_Pathway ko03030 DNA replication # KEGG_Pathway ko03430 Mismatch repair # KEGG_Pathway ko03440 Homologous recombination # MISCELLANEOUS DPO3B_ECOLI The temperature- and UV-sensitive allele dnaN159 does not grow at higher than 37 degrees Celsius. The global SOS response is chronically induced. The UV-sensitivity of dnaN159 is dependent upon pol IV (dinB), it has an enhanced Pol V-dependent mutation rate (umuC, umuD), and is absolutely dependent on the polymerase activity of Pol I (polA) for viability. # Organism DPO3B_ECOLI Escherichia coli (strain K12) # PATRIC 32122899 VBIEscCol129921_3825 # PDB 1JQJ X-ray; 2.90 A; A/B=1-366 # PDB 1JQL X-ray; 2.50 A; A=1-366 # PDB 1MMI X-ray; 1.85 A; A/B=1-366 # PDB 1OK7 X-ray; 1.65 A; A/B=1-366 # PDB 1UNN X-ray; 1.90 A; A/B=1-366 # PDB 1WAI Model; -; A/B=1-366 # PDB 2POL X-ray; 2.50 A; A/B=1-366 # PDB 2XUR X-ray; 1.90 A; A/B=1-366 # PDB 3BEP X-ray; 1.92 A; A/B=1-366 # PDB 3D1E X-ray; 1.90 A; A/B=1-366 # PDB 3D1F X-ray; 2.00 A; A/B=1-366 # PDB 3D1G X-ray; 1.64 A; A/B=1-366 # PDB 3F1V X-ray; 1.77 A; A/B=1-366 # PDB 3PWE X-ray; 2.20 A; A/B=1-366 # PDB 3Q4J X-ray; 2.30 A; A/B/C/D/E/F=1-366 # PDB 3Q4K X-ray; 2.60 A; A/B=1-366 # PDB 3Q4L X-ray; 1.95 A; A/B=1-366 # PDB 3QSB X-ray; 1.90 A; A/B=1-366 # PDB 4K3K X-ray; 1.85 A; A/B=1-366 # PDB 4K3L X-ray; 1.50 A; A/B=1-366 # PDB 4K3M X-ray; 1.85 A; A/B=1-366 # PDB 4K3O X-ray; 2.00 A; A/B=1-366 # PDB 4K3P X-ray; 2.15 A; A/B=1-366 # PDB 4K3Q X-ray; 1.85 A; A/B=1-366 # PDB 4K3R X-ray; 1.86 A; A/B=1-366 # PDB 4K3S X-ray; 1.75 A; A/B=1-366 # PDB 4MJP X-ray; 1.86 A; A/B=1-366 # PDB 4MJQ X-ray; 1.73 A; A/B=1-366 # PDB 4MJR X-ray; 1.62 A; A/B=1-366 # PDB 4N94 X-ray; 1.73 A; A/B=1-366 # PDB 4N95 X-ray; 1.80 A; A/B=1-366 # PDB 4N96 X-ray; 1.70 A; A/B=1-366 # PDB 4N97 X-ray; 1.97 A; A/B=1-366 # PDB 4N98 X-ray; 1.70 A; A/B=1-366 # PDB 4N99 X-ray; 2.30 A; A/B=1-366 # PDB 4N9A X-ray; 1.90 A; A/B=1-366 # PDB 5FKU EM; 8.34 A; B/C=1-366 # PDB 5FKV EM; 8.00 A; B/C=1-366 # PDB 5FKW EM; 7.30 A; B/C=1-366 # PIR A91510 DJEC3B # PIRSF PIRSF000804 DNA_pol_III_b # Pfam PF00712 DNA_pol3_beta # Pfam PF02767 DNA_pol3_beta_2 # Pfam PF02768 DNA_pol3_beta_3 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DPO3B_ECOLI DNA polymerase III subunit beta # RefSeq NP_418156 NC_000913.3 # RefSeq WP_000673464 NZ_LN832404.1 # SMART SM00480 POL3Bc # SUBCELLULAR LOCATION DPO3B_ECOLI Cytoplasm {ECO 0000269|PubMed 23994470}. Note=Localizes to midcell position when chromosomes are condensed during DNA replication. # SUBUNIT DPO3B_ECOLI The DNA polymerase holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential subassemblies the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core (subunits alpha, epsilon and theta) contains the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the beta sliding clamp processivity factor (this entry). The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork. This complex contains delta, delta', psi and chi, and copies of either or both of two different DnaX proteins, gamma and tau. The composition of the holoenzyme is, therefore (alpha,epsilon,theta)[2]-(gamma/tau)[3]-delta,delta', psi,chi- beta[4]. The beta chain is a homodimer when not associated with the other components. Can also be part of the RIDA complex (regulatory inactivation of DnaA), consisting of ATP-DnaA, ADP-Hda and DNA-loaded beta clamp. Probably also interacts with components of DNA polymerases I, II, IV and V. Binds to CrfC homooligomers at the midcell position during DNA replication. {ECO 0000269|PubMed 14592985, ECO 0000269|PubMed 15150238, ECO 0000269|PubMed 15466025, ECO 0000269|PubMed 18977760, ECO 0000269|PubMed 23994470}. # TIGRFAMs TIGR00663 dnan # eggNOG COG0592 LUCA # eggNOG ENOG4105CZ8 Bacteria BLAST swissprot:DPO3B_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DPO3B_ECOLI BioCyc ECOL316407:JW3678-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3678-MONOMER BioCyc EcoCyc:EG10242-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10242-MONOMER BioCyc MetaCyc:EG10242-MONOMER http://biocyc.org/getid?id=MetaCyc:EG10242-MONOMER COG COG0592 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0592 DIP DIP-36038N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-36038N DOI 10.1002/bies.950140206 http://dx.doi.org/10.1002/bies.950140206 DOI 10.1002/elps.1150180805 http://dx.doi.org/10.1002/elps.1150180805 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1016/0092-8674(92)90445-I http://dx.doi.org/10.1016/0092-8674(92)90445-I DOI 10.1016/0378-1119(84)90253-1 http://dx.doi.org/10.1016/0378-1119(84)90253-1 DOI 10.1016/0378-1119(86)90206-4 http://dx.doi.org/10.1016/0378-1119(86)90206-4 DOI 10.1016/j.celrep.2013.07.040 http://dx.doi.org/10.1016/j.celrep.2013.07.040 DOI 10.1016/j.molcel.2009.11.024 http://dx.doi.org/10.1016/j.molcel.2009.11.024 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1073/pnas.81.15.4622 http://dx.doi.org/10.1073/pnas.81.15.4622 DOI 10.1074/jbc.M803158200 http://dx.doi.org/10.1074/jbc.M803158200 DOI 10.1093/emboj/cdg568 http://dx.doi.org/10.1093/emboj/cdg568 DOI 10.1093/nar/12.16.6389 http://dx.doi.org/10.1093/nar/12.16.6389 DOI 10.1107/S0907444903009958 http://dx.doi.org/10.1107/S0907444903009958 DOI 10.1111/j.1365-2958.2012.08129.x http://dx.doi.org/10.1111/j.1365-2958.2012.08129.x DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1128/JB.186.11.3508-3515.2004 http://dx.doi.org/10.1128/JB.186.11.3508-3515.2004 DOI 10.1128/JB.186.20.6738-6748.2004 http://dx.doi.org/10.1128/JB.186.20.6738-6748.2004 EC_number EC:2.7.7.7 http://www.genome.jp/dbget-bin/www_bget?EC:2.7.7.7 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL J01602 http://www.ebi.ac.uk/ena/data/view/J01602 EMBL K02179 http://www.ebi.ac.uk/ena/data/view/K02179 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL M13822 http://www.ebi.ac.uk/ena/data/view/M13822 EMBL M19876 http://www.ebi.ac.uk/ena/data/view/M19876 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X04341 http://www.ebi.ac.uk/ena/data/view/X04341 ENZYME 2.7.7.7 http://enzyme.expasy.org/EC/2.7.7.7 EchoBASE EB0238 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0238 EcoGene EG10242 http://www.ecogene.org/geneInfo.php?eg_id=EG10242 EnsemblBacteria AAC76724 http://www.ensemblgenomes.org/id/AAC76724 EnsemblBacteria AAC76724 http://www.ensemblgenomes.org/id/AAC76724 EnsemblBacteria BAE77593 http://www.ensemblgenomes.org/id/BAE77593 EnsemblBacteria BAE77593 http://www.ensemblgenomes.org/id/BAE77593 EnsemblBacteria BAE77593 http://www.ensemblgenomes.org/id/BAE77593 EnsemblBacteria b3701 http://www.ensemblgenomes.org/id/b3701 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_component GO:0009360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009360 GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0003887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003887 GO_function GO:0008408 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008408 GO_function GO:0042802 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042802 GO_process GO:0006271 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006271 GO_process GO:0006974 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006974 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_function GO:0004518 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004518 GOslim_function GO:0016779 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016779 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0006950 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950 GeneID 948218 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948218 HOGENOM HOG000071791 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000071791&db=HOGENOM6 InParanoid P0A988 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A988 IntAct P0A988 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A988* IntEnz 2.7.7.7 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.7.7 InterPro IPR001001 http://www.ebi.ac.uk/interpro/entry/IPR001001 InterPro IPR022634 http://www.ebi.ac.uk/interpro/entry/IPR022634 InterPro IPR022635 http://www.ebi.ac.uk/interpro/entry/IPR022635 InterPro IPR022637 http://www.ebi.ac.uk/interpro/entry/IPR022637 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03032 http://www.genome.jp/dbget-bin/www_bget?ko03032 KEGG_Brite ko03032 http://www.genome.jp/dbget-bin/www_bget?ko03032 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Brite ko03400 http://www.genome.jp/dbget-bin/www_bget?ko03400 KEGG_Gene ecj:JW3678 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3678 KEGG_Gene eco:b3701 http://www.genome.jp/dbget-bin/www_bget?eco:b3701 KEGG_Orthology KO:K02338 http://www.genome.jp/dbget-bin/www_bget?KO:K02338 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Pathway ko00240 http://www.genome.jp/kegg-bin/show_pathway?ko00240 KEGG_Pathway ko03030 http://www.genome.jp/kegg-bin/show_pathway?ko03030 KEGG_Pathway ko03430 http://www.genome.jp/kegg-bin/show_pathway?ko03430 KEGG_Pathway ko03440 http://www.genome.jp/kegg-bin/show_pathway?ko03440 KEGG_Reaction rn:R00375 http://www.genome.jp/dbget-bin/www_bget?rn:R00375 KEGG_Reaction rn:R00376 http://www.genome.jp/dbget-bin/www_bget?rn:R00376 KEGG_Reaction rn:R00377 http://www.genome.jp/dbget-bin/www_bget?rn:R00377 KEGG_Reaction rn:R00378 http://www.genome.jp/dbget-bin/www_bget?rn:R00378 OMA THQIRLK http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=THQIRLK PDB 1JQJ http://www.ebi.ac.uk/pdbe-srv/view/entry/1JQJ PDB 1JQL http://www.ebi.ac.uk/pdbe-srv/view/entry/1JQL PDB 1MMI http://www.ebi.ac.uk/pdbe-srv/view/entry/1MMI PDB 1OK7 http://www.ebi.ac.uk/pdbe-srv/view/entry/1OK7 PDB 1UNN http://www.ebi.ac.uk/pdbe-srv/view/entry/1UNN PDB 1WAI http://www.ebi.ac.uk/pdbe-srv/view/entry/1WAI PDB 2POL http://www.ebi.ac.uk/pdbe-srv/view/entry/2POL PDB 2XUR http://www.ebi.ac.uk/pdbe-srv/view/entry/2XUR PDB 3BEP http://www.ebi.ac.uk/pdbe-srv/view/entry/3BEP PDB 3D1E http://www.ebi.ac.uk/pdbe-srv/view/entry/3D1E PDB 3D1F http://www.ebi.ac.uk/pdbe-srv/view/entry/3D1F PDB 3D1G http://www.ebi.ac.uk/pdbe-srv/view/entry/3D1G PDB 3F1V http://www.ebi.ac.uk/pdbe-srv/view/entry/3F1V PDB 3PWE http://www.ebi.ac.uk/pdbe-srv/view/entry/3PWE PDB 3Q4J http://www.ebi.ac.uk/pdbe-srv/view/entry/3Q4J PDB 3Q4K http://www.ebi.ac.uk/pdbe-srv/view/entry/3Q4K PDB 3Q4L http://www.ebi.ac.uk/pdbe-srv/view/entry/3Q4L PDB 3QSB http://www.ebi.ac.uk/pdbe-srv/view/entry/3QSB PDB 4K3K http://www.ebi.ac.uk/pdbe-srv/view/entry/4K3K PDB 4K3L http://www.ebi.ac.uk/pdbe-srv/view/entry/4K3L PDB 4K3M http://www.ebi.ac.uk/pdbe-srv/view/entry/4K3M PDB 4K3O http://www.ebi.ac.uk/pdbe-srv/view/entry/4K3O PDB 4K3P http://www.ebi.ac.uk/pdbe-srv/view/entry/4K3P PDB 4K3Q http://www.ebi.ac.uk/pdbe-srv/view/entry/4K3Q PDB 4K3R http://www.ebi.ac.uk/pdbe-srv/view/entry/4K3R PDB 4K3S http://www.ebi.ac.uk/pdbe-srv/view/entry/4K3S PDB 4MJP http://www.ebi.ac.uk/pdbe-srv/view/entry/4MJP PDB 4MJQ http://www.ebi.ac.uk/pdbe-srv/view/entry/4MJQ PDB 4MJR http://www.ebi.ac.uk/pdbe-srv/view/entry/4MJR PDB 4N94 http://www.ebi.ac.uk/pdbe-srv/view/entry/4N94 PDB 4N95 http://www.ebi.ac.uk/pdbe-srv/view/entry/4N95 PDB 4N96 http://www.ebi.ac.uk/pdbe-srv/view/entry/4N96 PDB 4N97 http://www.ebi.ac.uk/pdbe-srv/view/entry/4N97 PDB 4N98 http://www.ebi.ac.uk/pdbe-srv/view/entry/4N98 PDB 4N99 http://www.ebi.ac.uk/pdbe-srv/view/entry/4N99 PDB 4N9A http://www.ebi.ac.uk/pdbe-srv/view/entry/4N9A PDB 5FKU http://www.ebi.ac.uk/pdbe-srv/view/entry/5FKU PDB 5FKV http://www.ebi.ac.uk/pdbe-srv/view/entry/5FKV PDB 5FKW http://www.ebi.ac.uk/pdbe-srv/view/entry/5FKW PDBsum 1JQJ http://www.ebi.ac.uk/pdbsum/1JQJ PDBsum 1JQL http://www.ebi.ac.uk/pdbsum/1JQL PDBsum 1MMI http://www.ebi.ac.uk/pdbsum/1MMI PDBsum 1OK7 http://www.ebi.ac.uk/pdbsum/1OK7 PDBsum 1UNN http://www.ebi.ac.uk/pdbsum/1UNN PDBsum 1WAI http://www.ebi.ac.uk/pdbsum/1WAI PDBsum 2POL http://www.ebi.ac.uk/pdbsum/2POL PDBsum 2XUR http://www.ebi.ac.uk/pdbsum/2XUR PDBsum 3BEP http://www.ebi.ac.uk/pdbsum/3BEP PDBsum 3D1E http://www.ebi.ac.uk/pdbsum/3D1E PDBsum 3D1F http://www.ebi.ac.uk/pdbsum/3D1F PDBsum 3D1G http://www.ebi.ac.uk/pdbsum/3D1G PDBsum 3F1V http://www.ebi.ac.uk/pdbsum/3F1V PDBsum 3PWE http://www.ebi.ac.uk/pdbsum/3PWE PDBsum 3Q4J http://www.ebi.ac.uk/pdbsum/3Q4J PDBsum 3Q4K http://www.ebi.ac.uk/pdbsum/3Q4K PDBsum 3Q4L http://www.ebi.ac.uk/pdbsum/3Q4L PDBsum 3QSB http://www.ebi.ac.uk/pdbsum/3QSB PDBsum 4K3K http://www.ebi.ac.uk/pdbsum/4K3K PDBsum 4K3L http://www.ebi.ac.uk/pdbsum/4K3L PDBsum 4K3M http://www.ebi.ac.uk/pdbsum/4K3M PDBsum 4K3O http://www.ebi.ac.uk/pdbsum/4K3O PDBsum 4K3P http://www.ebi.ac.uk/pdbsum/4K3P PDBsum 4K3Q http://www.ebi.ac.uk/pdbsum/4K3Q PDBsum 4K3R http://www.ebi.ac.uk/pdbsum/4K3R PDBsum 4K3S http://www.ebi.ac.uk/pdbsum/4K3S PDBsum 4MJP http://www.ebi.ac.uk/pdbsum/4MJP PDBsum 4MJQ http://www.ebi.ac.uk/pdbsum/4MJQ PDBsum 4MJR http://www.ebi.ac.uk/pdbsum/4MJR PDBsum 4N94 http://www.ebi.ac.uk/pdbsum/4N94 PDBsum 4N95 http://www.ebi.ac.uk/pdbsum/4N95 PDBsum 4N96 http://www.ebi.ac.uk/pdbsum/4N96 PDBsum 4N97 http://www.ebi.ac.uk/pdbsum/4N97 PDBsum 4N98 http://www.ebi.ac.uk/pdbsum/4N98 PDBsum 4N99 http://www.ebi.ac.uk/pdbsum/4N99 PDBsum 4N9A http://www.ebi.ac.uk/pdbsum/4N9A PDBsum 5FKU http://www.ebi.ac.uk/pdbsum/5FKU PDBsum 5FKV http://www.ebi.ac.uk/pdbsum/5FKV PDBsum 5FKW http://www.ebi.ac.uk/pdbsum/5FKW PSORT swissprot:DPO3B_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DPO3B_ECOLI PSORT-B swissprot:DPO3B_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DPO3B_ECOLI PSORT2 swissprot:DPO3B_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DPO3B_ECOLI Pfam PF00712 http://pfam.xfam.org/family/PF00712 Pfam PF02767 http://pfam.xfam.org/family/PF02767 Pfam PF02768 http://pfam.xfam.org/family/PF02768 Phobius swissprot:DPO3B_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DPO3B_ECOLI PhylomeDB P0A988 http://phylomedb.org/?seqid=P0A988 ProteinModelPortal P0A988 http://www.proteinmodelportal.org/query/uniprot/P0A988 PubMed 12832762 http://www.ncbi.nlm.nih.gov/pubmed/12832762 PubMed 1349852 http://www.ncbi.nlm.nih.gov/pubmed/1349852 PubMed 14592985 http://www.ncbi.nlm.nih.gov/pubmed/14592985 PubMed 15150238 http://www.ncbi.nlm.nih.gov/pubmed/15150238 PubMed 15466025 http://www.ncbi.nlm.nih.gov/pubmed/15466025 PubMed 1575709 http://www.ncbi.nlm.nih.gov/pubmed/1575709 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 18977760 http://www.ncbi.nlm.nih.gov/pubmed/18977760 PubMed 20005847 http://www.ncbi.nlm.nih.gov/pubmed/20005847 PubMed 22716942 http://www.ncbi.nlm.nih.gov/pubmed/22716942 PubMed 23994470 http://www.ncbi.nlm.nih.gov/pubmed/23994470 PubMed 2841344 http://www.ncbi.nlm.nih.gov/pubmed/2841344 PubMed 3527871 http://www.ncbi.nlm.nih.gov/pubmed/3527871 PubMed 6089112 http://www.ncbi.nlm.nih.gov/pubmed/6089112 PubMed 6234204 http://www.ncbi.nlm.nih.gov/pubmed/6234204 PubMed 6379647 http://www.ncbi.nlm.nih.gov/pubmed/6379647 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298644 http://www.ncbi.nlm.nih.gov/pubmed/9298644 RefSeq NP_418156 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418156 RefSeq WP_000673464 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000673464 SMART SM00480 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00480 SMR P0A988 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A988 STRING 511145.b3701 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3701&targetmode=cogs STRING COG0592 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0592&targetmode=cogs TIGRFAMs TIGR00663 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00663 UniProtKB DPO3B_ECOLI http://www.uniprot.org/uniprot/DPO3B_ECOLI UniProtKB-AC P0A988 http://www.uniprot.org/uniprot/P0A988 charge swissprot:DPO3B_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DPO3B_ECOLI eggNOG COG0592 http://eggnogapi.embl.de/nog_data/html/tree/COG0592 eggNOG ENOG4105CZ8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CZ8 epestfind swissprot:DPO3B_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DPO3B_ECOLI garnier swissprot:DPO3B_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DPO3B_ECOLI helixturnhelix swissprot:DPO3B_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DPO3B_ECOLI hmoment swissprot:DPO3B_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DPO3B_ECOLI iep swissprot:DPO3B_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DPO3B_ECOLI inforesidue swissprot:DPO3B_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DPO3B_ECOLI octanol swissprot:DPO3B_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DPO3B_ECOLI pepcoil swissprot:DPO3B_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DPO3B_ECOLI pepdigest swissprot:DPO3B_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DPO3B_ECOLI pepinfo swissprot:DPO3B_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DPO3B_ECOLI pepnet swissprot:DPO3B_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DPO3B_ECOLI pepstats swissprot:DPO3B_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DPO3B_ECOLI pepwheel swissprot:DPO3B_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DPO3B_ECOLI pepwindow swissprot:DPO3B_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DPO3B_ECOLI sigcleave swissprot:DPO3B_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DPO3B_ECOLI ## Database ID URL or Descriptions # AltName YDDA_ECOLI CDS102 # BioGrid 4260785 207 # EcoGene EG11742 yddA # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0042626 ATPase activity, coupled to transmembrane movement of substances; IEA:InterPro. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # Gene3D 3.40.50.300 -; 1. # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR011527 ABC1_TM_dom # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism YDDA_ECOLI Escherichia coli (strain K12) # PATRIC 32118286 VBIEscCol129921_1563 # PIR C64903 C64903 # PROSITE PS00211 ABC_TRANSPORTER_1 # PROSITE PS50893 ABC_TRANSPORTER_2 # PROSITE PS50929 ABC_TM1F # Pfam PF00005 ABC_tran # Pfam PF06472 ABC_membrane_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YDDA_ECOLI Inner membrane ABC transporter ATP-binding protein YddA # RefSeq NP_416013 NC_000913.3 # RefSeq WP_000628576 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=CAA50732.1; Type=Erroneous initiation; Evidence={ECO 0000305}; # SIMILARITY Belongs to the ABC transporter superfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SIMILARITY Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA # SUBCELLULAR LOCATION YDDA_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF52540 SSF52540 # SUPFAM SSF90123 SSF90123 # TCDB 3.A.1.203.11 the atp-binding cassette (abc) superfamily # eggNOG COG4178 LUCA # eggNOG ENOG4105CQ0 Bacteria BLAST swissprot:YDDA_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YDDA_ECOLI BioCyc ECOL316407:JW5242-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5242-MONOMER BioCyc EcoCyc:YDDA-MONOMER http://biocyc.org/getid?id=EcoCyc:YDDA-MONOMER COG COG4178 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4178 DOI 10.1016/S0300-9084(97)84334-9 http://dx.doi.org/10.1016/S0300-9084(97)84334-9 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X71917 http://www.ebi.ac.uk/ena/data/view/X71917 EchoBASE EB1693 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1693 EcoGene EG11742 http://www.ecogene.org/geneInfo.php?eg_id=EG11742 EnsemblBacteria AAC74569 http://www.ensemblgenomes.org/id/AAC74569 EnsemblBacteria AAC74569 http://www.ensemblgenomes.org/id/AAC74569 EnsemblBacteria BAA15167 http://www.ensemblgenomes.org/id/BAA15167 EnsemblBacteria BAA15167 http://www.ensemblgenomes.org/id/BAA15167 EnsemblBacteria BAA15167 http://www.ensemblgenomes.org/id/BAA15167 EnsemblBacteria b1496 http://www.ensemblgenomes.org/id/b1496 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0042626 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042626 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 945945 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945945 HOGENOM HOG000255118 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000255118&db=HOGENOM6 InParanoid P31826 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P31826 InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR011527 http://www.ebi.ac.uk/interpro/entry/IPR011527 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW5242 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5242 KEGG_Gene eco:b1496 http://www.genome.jp/dbget-bin/www_bget?eco:b1496 KEGG_Orthology KO:K02471 http://www.genome.jp/dbget-bin/www_bget?KO:K02471 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA VHIRDNA http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VHIRDNA PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PROSITE PS50929 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50929 PSORT swissprot:YDDA_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YDDA_ECOLI PSORT-B swissprot:YDDA_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YDDA_ECOLI PSORT2 swissprot:YDDA_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YDDA_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Pfam PF06472 http://pfam.xfam.org/family/PF06472 Phobius swissprot:YDDA_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YDDA_ECOLI PhylomeDB P31826 http://phylomedb.org/?seqid=P31826 ProteinModelPortal P31826 http://www.proteinmodelportal.org/query/uniprot/P31826 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9116051 http://www.ncbi.nlm.nih.gov/pubmed/9116051 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416013 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416013 RefSeq WP_000628576 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000628576 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 STRING 511145.b1496 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1496&targetmode=cogs STRING COG4178 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4178&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 SUPFAM SSF90123 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF90123 TCDB 3.A.1.203.11 http://www.tcdb.org/search/result.php?tc=3.A.1.203.11 UniProtKB YDDA_ECOLI http://www.uniprot.org/uniprot/YDDA_ECOLI UniProtKB-AC P31826 http://www.uniprot.org/uniprot/P31826 charge swissprot:YDDA_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YDDA_ECOLI eggNOG COG4178 http://eggnogapi.embl.de/nog_data/html/tree/COG4178 eggNOG ENOG4105CQ0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CQ0 epestfind swissprot:YDDA_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YDDA_ECOLI garnier swissprot:YDDA_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YDDA_ECOLI helixturnhelix swissprot:YDDA_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YDDA_ECOLI hmoment swissprot:YDDA_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YDDA_ECOLI iep swissprot:YDDA_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YDDA_ECOLI inforesidue swissprot:YDDA_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YDDA_ECOLI octanol swissprot:YDDA_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YDDA_ECOLI pepcoil swissprot:YDDA_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YDDA_ECOLI pepdigest swissprot:YDDA_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YDDA_ECOLI pepinfo swissprot:YDDA_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YDDA_ECOLI pepnet swissprot:YDDA_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YDDA_ECOLI pepstats swissprot:YDDA_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YDDA_ECOLI pepwheel swissprot:YDDA_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YDDA_ECOLI pepwindow swissprot:YDDA_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YDDA_ECOLI sigcleave swissprot:YDDA_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YDDA_ECOLI ## Database ID URL or Descriptions # BioGrid 4260390 537 # EcoGene EG10322 fliL # FUNCTION FLIL_ECOLI Controls the rotational direction of flagella during chemotaxis. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0009425 bacterial-type flagellum basal body; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0006935 chemotaxis; IEA:UniProtKB-KW. # GO_process GO:0071978 bacterial-type flagellum-dependent swarming motility; IMP:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0040011 locomotion # GOslim_process GO:0048870 cell motility # IntAct P0ABX8 8 # InterPro IPR005503 FliL # KEGG_Brite ko02035 Bacterial motility proteins # Organism FLIL_ECOLI Escherichia coli (strain K12) # PATRIC 32119217 VBIEscCol129921_2023 # PIR A29842 XMECF1 # Pfam PF03748 FliL # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName FLIL_ECOLI Flagellar protein FliL # RefSeq NP_416454 NC_000913.3 # RefSeq WP_000133106 NZ_LN832404.1 # SIMILARITY Belongs to the FliL family. {ECO 0000305}. # SUBCELLULAR LOCATION FLIL_ECOLI Cell inner membrane {ECO 0000305}; Single- pass membrane protein {ECO 0000305}. # eggNOG COG1580 LUCA # eggNOG ENOG4107ZI8 Bacteria BLAST swissprot:FLIL_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:FLIL_ECOLI BioCyc ECOL316407:JW1928-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1928-MONOMER BioCyc EcoCyc:EG10322-MONOMER http://biocyc.org/getid?id=EcoCyc:EG10322-MONOMER COG COG1580 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1580 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL L43491 http://www.ebi.ac.uk/ena/data/view/L43491 EMBL M12784 http://www.ebi.ac.uk/ena/data/view/M12784 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB0318 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0318 EcoGene EG10322 http://www.ecogene.org/geneInfo.php?eg_id=EG10322 EnsemblBacteria AAC75011 http://www.ensemblgenomes.org/id/AAC75011 EnsemblBacteria AAC75011 http://www.ensemblgenomes.org/id/AAC75011 EnsemblBacteria BAA15769 http://www.ensemblgenomes.org/id/BAA15769 EnsemblBacteria BAA15769 http://www.ensemblgenomes.org/id/BAA15769 EnsemblBacteria BAA15769 http://www.ensemblgenomes.org/id/BAA15769 EnsemblBacteria b1944 http://www.ensemblgenomes.org/id/b1944 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0009425 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009425 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0006935 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006935 GO_process GO:0071978 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071978 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0040011 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0040011 GOslim_process GO:0048870 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048870 GeneID 946443 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946443 HOGENOM HOG000253592 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000253592&db=HOGENOM6 InParanoid P0ABX8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0ABX8 IntAct P0ABX8 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0ABX8* InterPro IPR005503 http://www.ebi.ac.uk/interpro/entry/IPR005503 KEGG_Brite ko02035 http://www.genome.jp/dbget-bin/www_bget?ko02035 KEGG_Gene ecj:JW1928 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1928 KEGG_Gene eco:b1944 http://www.genome.jp/dbget-bin/www_bget?eco:b1944 KEGG_Orthology KO:K02415 http://www.genome.jp/dbget-bin/www_bget?KO:K02415 OMA YWRMQQH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=YWRMQQH PSORT swissprot:FLIL_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:FLIL_ECOLI PSORT-B swissprot:FLIL_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:FLIL_ECOLI PSORT2 swissprot:FLIL_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:FLIL_ECOLI Pfam PF03748 http://pfam.xfam.org/family/PF03748 Phobius swissprot:FLIL_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:FLIL_ECOLI PhylomeDB P0ABX8 http://phylomedb.org/?seqid=P0ABX8 ProteinModelPortal P0ABX8 http://www.proteinmodelportal.org/query/uniprot/P0ABX8 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3519573 http://www.ncbi.nlm.nih.gov/pubmed/3519573 PubMed 8631687 http://www.ncbi.nlm.nih.gov/pubmed/8631687 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416454 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416454 RefSeq WP_000133106 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000133106 STRING 511145.b1944 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1944&targetmode=cogs STRING COG1580 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1580&targetmode=cogs UniProtKB FLIL_ECOLI http://www.uniprot.org/uniprot/FLIL_ECOLI UniProtKB-AC P0ABX8 http://www.uniprot.org/uniprot/P0ABX8 charge swissprot:FLIL_ECOLI http://rest.g-language.org/emboss/charge/swissprot:FLIL_ECOLI eggNOG COG1580 http://eggnogapi.embl.de/nog_data/html/tree/COG1580 eggNOG ENOG4107ZI8 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107ZI8 epestfind swissprot:FLIL_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:FLIL_ECOLI garnier swissprot:FLIL_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:FLIL_ECOLI helixturnhelix swissprot:FLIL_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:FLIL_ECOLI hmoment swissprot:FLIL_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:FLIL_ECOLI iep swissprot:FLIL_ECOLI http://rest.g-language.org/emboss/iep/swissprot:FLIL_ECOLI inforesidue swissprot:FLIL_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:FLIL_ECOLI octanol swissprot:FLIL_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:FLIL_ECOLI pepcoil swissprot:FLIL_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:FLIL_ECOLI pepdigest swissprot:FLIL_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:FLIL_ECOLI pepinfo swissprot:FLIL_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:FLIL_ECOLI pepnet swissprot:FLIL_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:FLIL_ECOLI pepstats swissprot:FLIL_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:FLIL_ECOLI pepwheel swissprot:FLIL_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:FLIL_ECOLI pepwindow swissprot:FLIL_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:FLIL_ECOLI sigcleave swissprot:FLIL_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:FLIL_ECOLI ## Database ID URL or Descriptions # BioGrid 4261794 195 # EcoGene EG11155 ygdB # InterPro IPR019652 DUF2509 # Organism YGDB_ECOLI Escherichia coli (strain K12) # PATRIC 32121066 VBIEscCol129921_2922 # PIR D24137 QQEC13 # Pfam PF10713 DUF2509 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YGDB_ECOLI Uncharacterized protein YgdB # RefSeq NP_417301 NC_000913.3 # RefSeq WP_001078376 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=AAB40471.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA27602.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO 0000305}; # eggNOG ENOG4105SEN Bacteria # eggNOG ENOG41120CI LUCA BLAST swissprot:YGDB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YGDB_ECOLI BioCyc ECOL316407:JW5450-MONOMER http://biocyc.org/getid?id=ECOL316407:JW5450-MONOMER BioCyc EcoCyc:EG11155-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11155-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/nar/14.11.4437 http://dx.doi.org/10.1093/nar/14.11.4437 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U29581 http://www.ebi.ac.uk/ena/data/view/U29581 EMBL X03966 http://www.ebi.ac.uk/ena/data/view/X03966 EchoBASE EB1144 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1144 EcoGene EG11155 http://www.ecogene.org/geneInfo.php?eg_id=EG11155 EnsemblBacteria AAC75863 http://www.ensemblgenomes.org/id/AAC75863 EnsemblBacteria AAC75863 http://www.ensemblgenomes.org/id/AAC75863 EnsemblBacteria BAE76893 http://www.ensemblgenomes.org/id/BAE76893 EnsemblBacteria BAE76893 http://www.ensemblgenomes.org/id/BAE76893 EnsemblBacteria BAE76893 http://www.ensemblgenomes.org/id/BAE76893 EnsemblBacteria b2824 http://www.ensemblgenomes.org/id/b2824 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 944763 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=944763 HOGENOM HOG000124346 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000124346&db=HOGENOM6 InterPro IPR019652 http://www.ebi.ac.uk/interpro/entry/IPR019652 KEGG_Gene ecj:JW5450 http://www.genome.jp/dbget-bin/www_bget?ecj:JW5450 KEGG_Gene eco:b2824 http://www.genome.jp/dbget-bin/www_bget?eco:b2824 OMA AHSALQW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=AHSALQW PSORT swissprot:YGDB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YGDB_ECOLI PSORT-B swissprot:YGDB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YGDB_ECOLI PSORT2 swissprot:YGDB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YGDB_ECOLI Pfam PF10713 http://pfam.xfam.org/family/PF10713 Phobius swissprot:YGDB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YGDB_ECOLI ProteinModelPortal P08370 http://www.proteinmodelportal.org/query/uniprot/P08370 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3520484 http://www.ncbi.nlm.nih.gov/pubmed/3520484 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417301 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417301 RefSeq WP_001078376 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001078376 STRING 511145.b2824 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2824&targetmode=cogs UniProtKB YGDB_ECOLI http://www.uniprot.org/uniprot/YGDB_ECOLI UniProtKB-AC P08370 http://www.uniprot.org/uniprot/P08370 charge swissprot:YGDB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YGDB_ECOLI eggNOG ENOG4105SEN http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105SEN eggNOG ENOG41120CI http://eggnogapi.embl.de/nog_data/html/tree/ENOG41120CI epestfind swissprot:YGDB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YGDB_ECOLI garnier swissprot:YGDB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YGDB_ECOLI helixturnhelix swissprot:YGDB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YGDB_ECOLI hmoment swissprot:YGDB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YGDB_ECOLI iep swissprot:YGDB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YGDB_ECOLI inforesidue swissprot:YGDB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YGDB_ECOLI octanol swissprot:YGDB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YGDB_ECOLI pepcoil swissprot:YGDB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YGDB_ECOLI pepdigest swissprot:YGDB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YGDB_ECOLI pepinfo swissprot:YGDB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YGDB_ECOLI pepnet swissprot:YGDB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YGDB_ECOLI pepstats swissprot:YGDB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YGDB_ECOLI pepwheel swissprot:YGDB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YGDB_ECOLI pepwindow swissprot:YGDB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YGDB_ECOLI sigcleave swissprot:YGDB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YGDB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260469 13 # EcoGene EG12041 yejF # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0043190 ATP-binding cassette (ABC) transporter complex; ISS:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0042626 ATPase activity, coupled to transmembrane movement of substances; ISS:EcoCyc. # GO_process GO:0042884 microcin transport; IMP:EcoCyc. # GOslim_component GO:0005886 plasma membrane # GOslim_component GO:0043234 protein complex # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006810 transport # Gene3D 3.40.50.300 -; 2. # IntAct P33916 10 # InterPro IPR003439 ABC_transporter-like # InterPro IPR003593 AAA+_ATPase # InterPro IPR013563 Oligopep_ABC_C # InterPro IPR017871 ABC_transporter_CS # InterPro IPR027417 P-loop_NTPase # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00349 Microcin C transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism YEJF_ECOLI Escherichia coli (strain K12) # PATRIC 32119715 VBIEscCol129921_2268 # PIR C64987 C64987 # PROSITE PS00211 ABC_TRANSPORTER_1; 2 # PROSITE PS50893 ABC_TRANSPORTER_2; 2 # Pfam PF00005 ABC_tran; 2 # Pfam PF08352 oligo_HPY; 2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YEJF_ECOLI Uncharacterized ABC transporter ATP-binding protein YejF # RefSeq NP_416685 NC_000913.3 # RefSeq WP_000194927 NZ_LN832404.1 # SIMILARITY Belongs to the ABC transporter superfamily. {ECO 0000305}. # SIMILARITY Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule PRU00434}. # SMART SM00382 AAA; 2 # SUPFAM SSF52540 SSF52540; 2 # TCDB 3.A.1.5.21 the atp-binding cassette (abc) superfamily # eggNOG COG4172 LUCA # eggNOG ENOG4108JQ5 Bacteria BLAST swissprot:YEJF_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YEJF_ECOLI BioCyc ECOL316407:JW2168-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2168-MONOMER BioCyc EcoCyc:YEJF-MONOMER http://biocyc.org/getid?id=EcoCyc:YEJF-MONOMER COG COG4172 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4172 DIP DIP-11936N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11936N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00008 http://www.ebi.ac.uk/ena/data/view/U00008 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB1975 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1975 EcoGene EG12041 http://www.ecogene.org/geneInfo.php?eg_id=EG12041 EnsemblBacteria AAC75241 http://www.ensemblgenomes.org/id/AAC75241 EnsemblBacteria AAC75241 http://www.ensemblgenomes.org/id/AAC75241 EnsemblBacteria BAA15988 http://www.ensemblgenomes.org/id/BAA15988 EnsemblBacteria BAA15988 http://www.ensemblgenomes.org/id/BAA15988 EnsemblBacteria BAA15988 http://www.ensemblgenomes.org/id/BAA15988 EnsemblBacteria b2180 http://www.ensemblgenomes.org/id/b2180 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0043190 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043190 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0042626 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042626 GO_process GO:0042884 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042884 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_component GO:0043234 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043234 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 3.40.50.300 http://www.cathdb.info/version/latest/superfamily/3.40.50.300 GeneID 946689 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946689 InParanoid P33916 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P33916 IntAct P33916 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P33916* InterPro IPR003439 http://www.ebi.ac.uk/interpro/entry/IPR003439 InterPro IPR003593 http://www.ebi.ac.uk/interpro/entry/IPR003593 InterPro IPR013563 http://www.ebi.ac.uk/interpro/entry/IPR013563 InterPro IPR017871 http://www.ebi.ac.uk/interpro/entry/IPR017871 InterPro IPR027417 http://www.ebi.ac.uk/interpro/entry/IPR027417 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW2168 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2168 KEGG_Gene eco:b2180 http://www.genome.jp/dbget-bin/www_bget?eco:b2180 KEGG_Orthology KO:K13896 http://www.genome.jp/dbget-bin/www_bget?KO:K13896 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 MINT MINT-1242905 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1242905 OMA WFPIRKG http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=WFPIRKG PROSITE PS00211 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00211 PROSITE PS50893 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50893 PSORT swissprot:YEJF_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YEJF_ECOLI PSORT-B swissprot:YEJF_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YEJF_ECOLI PSORT2 swissprot:YEJF_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YEJF_ECOLI Pfam PF00005 http://pfam.xfam.org/family/PF00005 Pfam PF08352 http://pfam.xfam.org/family/PF08352 Phobius swissprot:YEJF_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YEJF_ECOLI PhylomeDB P33916 http://phylomedb.org/?seqid=P33916 ProteinModelPortal P33916 http://www.proteinmodelportal.org/query/uniprot/P33916 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416685 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416685 RefSeq WP_000194927 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000194927 SMART SM00382 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00382 STRING 511145.b2180 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2180&targetmode=cogs STRING COG4172 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG4172&targetmode=cogs SUPFAM SSF52540 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52540 TCDB 3.A.1.5.21 http://www.tcdb.org/search/result.php?tc=3.A.1.5.21 UniProtKB YEJF_ECOLI http://www.uniprot.org/uniprot/YEJF_ECOLI UniProtKB-AC P33916 http://www.uniprot.org/uniprot/P33916 charge swissprot:YEJF_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YEJF_ECOLI eggNOG COG4172 http://eggnogapi.embl.de/nog_data/html/tree/COG4172 eggNOG ENOG4108JQ5 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4108JQ5 epestfind swissprot:YEJF_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YEJF_ECOLI garnier swissprot:YEJF_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YEJF_ECOLI helixturnhelix swissprot:YEJF_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YEJF_ECOLI hmoment swissprot:YEJF_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YEJF_ECOLI iep swissprot:YEJF_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YEJF_ECOLI inforesidue swissprot:YEJF_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YEJF_ECOLI octanol swissprot:YEJF_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YEJF_ECOLI pepcoil swissprot:YEJF_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YEJF_ECOLI pepdigest swissprot:YEJF_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YEJF_ECOLI pepinfo swissprot:YEJF_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YEJF_ECOLI pepnet swissprot:YEJF_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YEJF_ECOLI pepstats swissprot:YEJF_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YEJF_ECOLI pepwheel swissprot:YEJF_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YEJF_ECOLI pepwindow swissprot:YEJF_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YEJF_ECOLI sigcleave swissprot:YEJF_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YEJF_ECOLI ## Database ID URL or Descriptions # AltName DDLB_ECOLI D-Ala-D-Ala ligase B # AltName DDLB_ECOLI D-alanylalanine synthetase B # BRENDA 6.3.2 2026 # BioGrid 4261114 304 # CATALYTIC ACTIVITY DDLB_ECOLI ATP + 2 D-alanine = ADP + phosphate + D- alanyl-D-alanine. # COFACTOR DDLB_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000250}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000250}; Note=Binds 2 magnesium or manganese ions per subunit. {ECO 0000250}; # EcoGene EG10214 ddlB # FUNCTION DDLB_ECOLI Cell wall formation. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IEA:UniProtKB-HAMAP. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-HAMAP. # GO_function GO:0008716 D-alanine-D-alanine ligase activity; IDA:EcoCyc. # GO_function GO:0030145 manganese ion binding; IEA:UniProtKB-HAMAP. # GO_process GO:0008360 regulation of cell shape; IEA:UniProtKB-KW. # GO_process GO:0009252 peptidoglycan biosynthetic process; IMP:EcoCyc. # GO_process GO:0071555 cell wall organization; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0016874 ligase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0008150 biological_process # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0071554 cell wall organization or biogenesis # Gene3D 3.30.1490.20 -; 1. # Gene3D 3.30.470.20 -; 2. # Gene3D 3.40.50.20 -; 1. # HAMAP MF_00047 Dala_Dala_lig # IntAct P07862 4 # InterPro IPR000291 D-Ala_lig_Van_CS # InterPro IPR005905 D_ala_D_ala # InterPro IPR011095 Dala_Dala_lig_C # InterPro IPR011127 Dala_Dala_lig_N # InterPro IPR011761 ATP-grasp # InterPro IPR013815 ATP_grasp_subdomain_1 # InterPro IPR013816 ATP_grasp_subdomain_2 # InterPro IPR016185 PreATP-grasp_dom # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00473 D-Alanine metabolism # KEGG_Pathway ko00550 Peptidoglycan biosynthesis # Organism DDLB_ECOLI Escherichia coli (strain K12) # PATHWAY DDLB_ECOLI Cell wall biogenesis; peptidoglycan biosynthesis. # PATRIC 32115289 VBIEscCol129921_0096 # PDB 1IOV X-ray; 2.20 A; A=1-306 # PDB 1IOW X-ray; 1.90 A; A=1-306 # PDB 2DLN X-ray; 2.30 A; A=1-306 # PDB 4C5A X-ray; 1.65 A; A/B=1-306 # PDB 4C5B X-ray; 1.50 A; A/B=1-306 # PDB 4C5C X-ray; 1.40 A; A/B=1-306 # PIR A30289 CEECDL # PIRSF PIRSF039102 Ddl/VanB # PROSITE PS00843 DALA_DALA_LIGASE_1 # PROSITE PS00844 DALA_DALA_LIGASE_2 # PROSITE PS50975 ATP_GRASP # Pfam PF01820 Dala_Dala_lig_N # Pfam PF07478 Dala_Dala_lig_C # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DDLB_ECOLI D-alanine--D-alanine ligase B # RefSeq NP_414634 NC_000913.3 # RefSeq WP_000130056 NZ_LN832404.1 # SIMILARITY Belongs to the D-alanine--D-alanine ligase family. {ECO 0000305}. # SIMILARITY Contains 1 ATP-grasp domain. {ECO 0000305}. # SUBCELLULAR LOCATION DDLB_ECOLI Cytoplasm. # SUBUNIT DDLB_ECOLI Monomer. # SUPFAM SSF52440 SSF52440 # TIGRFAMs TIGR01205 D_ala_D_alaTIGR # eggNOG COG1181 LUCA # eggNOG ENOG4105CPF Bacteria BLAST swissprot:DDLB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DDLB_ECOLI BioCyc ECOL316407:JW0090-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0090-MONOMER BioCyc EcoCyc:DALADALALIGB-MONOMER http://biocyc.org/getid?id=EcoCyc:DALADALALIGB-MONOMER BioCyc MetaCyc:DALADALALIGB-MONOMER http://biocyc.org/getid?id=MetaCyc:DALADALALIGB-MONOMER COG COG1181 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1181 DOI 10.1021/bi962431t http://dx.doi.org/10.1021/bi962431t DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1042/bj2820747 http://dx.doi.org/10.1042/bj2820747 DOI 10.1093/nar/18.13.4014 http://dx.doi.org/10.1093/nar/18.13.4014 DOI 10.1093/nar/20.13.3305 http://dx.doi.org/10.1093/nar/20.13.3305 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 DOI 10.1126/science.7939684 http://dx.doi.org/10.1126/science.7939684 EC_number EC:6.3.2.4 http://www.genome.jp/dbget-bin/www_bget?EC:6.3.2.4 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K02668 http://www.ebi.ac.uk/ena/data/view/K02668 EMBL M14029 http://www.ebi.ac.uk/ena/data/view/M14029 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X52644 http://www.ebi.ac.uk/ena/data/view/X52644 EMBL X55034 http://www.ebi.ac.uk/ena/data/view/X55034 ENZYME 6.3.2.4 http://enzyme.expasy.org/EC/6.3.2.4 EchoBASE EB0210 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0210 EcoGene EG10214 http://www.ecogene.org/geneInfo.php?eg_id=EG10214 EnsemblBacteria AAC73203 http://www.ensemblgenomes.org/id/AAC73203 EnsemblBacteria AAC73203 http://www.ensemblgenomes.org/id/AAC73203 EnsemblBacteria BAB96660 http://www.ensemblgenomes.org/id/BAB96660 EnsemblBacteria BAB96660 http://www.ensemblgenomes.org/id/BAB96660 EnsemblBacteria BAB96660 http://www.ensemblgenomes.org/id/BAB96660 EnsemblBacteria b0092 http://www.ensemblgenomes.org/id/b0092 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0008716 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008716 GO_function GO:0030145 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030145 GO_process GO:0008360 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008360 GO_process GO:0009252 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009252 GO_process GO:0071555 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071555 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0016874 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016874 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0008150 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0071554 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071554 Gene3D 3.30.1490.20 http://www.cathdb.info/version/latest/superfamily/3.30.1490.20 Gene3D 3.30.470.20 http://www.cathdb.info/version/latest/superfamily/3.30.470.20 Gene3D 3.40.50.20 http://www.cathdb.info/version/latest/superfamily/3.40.50.20 GeneID 946324 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946324 HAMAP MF_00047 http://hamap.expasy.org/unirule/MF_00047 HOGENOM HOG000011592 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000011592&db=HOGENOM6 InParanoid P07862 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P07862 IntAct P07862 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P07862* IntEnz 6.3.2.4 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=6.3.2.4 InterPro IPR000291 http://www.ebi.ac.uk/interpro/entry/IPR000291 InterPro IPR005905 http://www.ebi.ac.uk/interpro/entry/IPR005905 InterPro IPR011095 http://www.ebi.ac.uk/interpro/entry/IPR011095 InterPro IPR011127 http://www.ebi.ac.uk/interpro/entry/IPR011127 InterPro IPR011761 http://www.ebi.ac.uk/interpro/entry/IPR011761 InterPro IPR013815 http://www.ebi.ac.uk/interpro/entry/IPR013815 InterPro IPR013816 http://www.ebi.ac.uk/interpro/entry/IPR013816 InterPro IPR016185 http://www.ebi.ac.uk/interpro/entry/IPR016185 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0090 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0090 KEGG_Gene eco:b0092 http://www.genome.jp/dbget-bin/www_bget?eco:b0092 KEGG_Orthology KO:K01921 http://www.genome.jp/dbget-bin/www_bget?KO:K01921 KEGG_Pathway ko00473 http://www.genome.jp/kegg-bin/show_pathway?ko00473 KEGG_Pathway ko00550 http://www.genome.jp/kegg-bin/show_pathway?ko00550 KEGG_Reaction rn:R01150 http://www.genome.jp/dbget-bin/www_bget?rn:R01150 OMA FQHDDEV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=FQHDDEV PDB 1IOV http://www.ebi.ac.uk/pdbe-srv/view/entry/1IOV PDB 1IOW http://www.ebi.ac.uk/pdbe-srv/view/entry/1IOW PDB 2DLN http://www.ebi.ac.uk/pdbe-srv/view/entry/2DLN PDB 4C5A http://www.ebi.ac.uk/pdbe-srv/view/entry/4C5A PDB 4C5B http://www.ebi.ac.uk/pdbe-srv/view/entry/4C5B PDB 4C5C http://www.ebi.ac.uk/pdbe-srv/view/entry/4C5C PDBsum 1IOV http://www.ebi.ac.uk/pdbsum/1IOV PDBsum 1IOW http://www.ebi.ac.uk/pdbsum/1IOW PDBsum 2DLN http://www.ebi.ac.uk/pdbsum/2DLN PDBsum 4C5A http://www.ebi.ac.uk/pdbsum/4C5A PDBsum 4C5B http://www.ebi.ac.uk/pdbsum/4C5B PDBsum 4C5C http://www.ebi.ac.uk/pdbsum/4C5C PROSITE PS00843 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00843 PROSITE PS00844 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00844 PROSITE PS50975 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50975 PSORT swissprot:DDLB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DDLB_ECOLI PSORT-B swissprot:DDLB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DDLB_ECOLI PSORT2 swissprot:DDLB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DDLB_ECOLI Pfam PF01820 http://pfam.xfam.org/family/PF01820 Pfam PF07478 http://pfam.xfam.org/family/PF07478 Phobius swissprot:DDLB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DDLB_ECOLI PhylomeDB P07862 http://phylomedb.org/?seqid=P07862 ProteinModelPortal P07862 http://www.proteinmodelportal.org/query/uniprot/P07862 PubMed 1554356 http://www.ncbi.nlm.nih.gov/pubmed/1554356 PubMed 1630901 http://www.ncbi.nlm.nih.gov/pubmed/1630901 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2197603 http://www.ncbi.nlm.nih.gov/pubmed/2197603 PubMed 2228979 http://www.ncbi.nlm.nih.gov/pubmed/2228979 PubMed 3528126 http://www.ncbi.nlm.nih.gov/pubmed/3528126 PubMed 7939684 http://www.ncbi.nlm.nih.gov/pubmed/7939684 PubMed 9054558 http://www.ncbi.nlm.nih.gov/pubmed/9054558 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_414634 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_414634 RefSeq WP_000130056 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000130056 SMR P07862 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P07862 STRING 511145.b0092 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0092&targetmode=cogs STRING COG1181 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1181&targetmode=cogs SUPFAM SSF52440 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52440 TIGRFAMs TIGR01205 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01205 UniProtKB DDLB_ECOLI http://www.uniprot.org/uniprot/DDLB_ECOLI UniProtKB-AC P07862 http://www.uniprot.org/uniprot/P07862 charge swissprot:DDLB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DDLB_ECOLI eggNOG COG1181 http://eggnogapi.embl.de/nog_data/html/tree/COG1181 eggNOG ENOG4105CPF http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CPF epestfind swissprot:DDLB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DDLB_ECOLI garnier swissprot:DDLB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DDLB_ECOLI helixturnhelix swissprot:DDLB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DDLB_ECOLI hmoment swissprot:DDLB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DDLB_ECOLI iep swissprot:DDLB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DDLB_ECOLI inforesidue swissprot:DDLB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DDLB_ECOLI octanol swissprot:DDLB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DDLB_ECOLI pepcoil swissprot:DDLB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DDLB_ECOLI pepdigest swissprot:DDLB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DDLB_ECOLI pepinfo swissprot:DDLB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DDLB_ECOLI pepnet swissprot:DDLB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DDLB_ECOLI pepstats swissprot:DDLB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DDLB_ECOLI pepwheel swissprot:DDLB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DDLB_ECOLI pepwindow swissprot:DDLB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DDLB_ECOLI sigcleave swissprot:DDLB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DDLB_ECOLI ## Database ID URL or Descriptions # AltName 5-phospho-D-ribosyl alpha-1-diphosphate {ECO:0000255|HAMAP-Rule MF_00583} # AltName KPRS_ECOLI Phosphoribosyl pyrophosphate synthase {ECO 0000255|HAMAP-Rule MF_00583, ECO 0000303|PubMed 2542328, ECO 0000303|PubMed 3009477, ECO 0000303|PubMed 6290219} # AltName Phosphoribosyl diphosphate synthase {ECO:0000255|HAMAP-Rule MF_00583} # BIOPHYSICOCHEMICAL PROPERTIES KPRS_ECOLI Kinetic parameters KM=0.094 mM for ATP (at pH 8 and 37 degrees Celsius) {ECO 0000269|PubMed 3009477}; KM=0.097 mM for ATP (at pH 8.5 and 37 degrees Celsius) {ECO 0000269|PubMed 8679571}; KM=0.138 mM for Rib-5-P (at pH 8 and 37 degrees Celsius) {ECO 0000269|PubMed 3009477}; KM=0.23 mM for ATP (at pH 8 and 37 degrees Celsius) {ECO 0000269|PubMed 2542328}; KM=0.24 uM for Rib-5-P (at 37 degrees Celsius) {ECO 0000269|PubMed 6290219}; KM=0.28 mM for Rib-5-P (at pH 8.5 and 37 degrees Celsius) {ECO 0000269|PubMed 8679571}; KM=0.3 mM for Rib-5-P (with 20 mM ATP at pH 8 and 37 degrees Celsius) {ECO 0000269|PubMed 2542328}; KM=1 mM for ATP (at 37 degrees Celsius) {ECO 0000269|PubMed 6290219}; Vmax=129 umol/min/mg enzyme toward Rib-5-P (at pH 8.5 and 37 degrees Celsius) {ECO 0000269|PubMed 8679571}; Vmax=143 umol/min/mg enzyme toward ATP (at pH 8.5 and 37 degrees Celsius) {ECO 0000269|PubMed 8679571}; pH dependence Optimum pH is between 9.7 and 9.8. {ECO 0000269|PubMed 3009477}; # BioGrid 4260813 13 # CATALYTIC ACTIVITY KPRS_ECOLI ATP + D-ribose 5-phosphate = AMP + 5-phospho- alpha-D-ribose 1-diphosphate. {ECO 0000255|HAMAP-Rule MF_00583, ECO 0000269|PubMed 2542328, ECO 0000269|PubMed 3009477, ECO 0000269|PubMed 6290219, ECO 0000269|PubMed 8679571}. # CDD cd06223 PRTases_typeI # COFACTOR KPRS_ECOLI Name=Mg(2+); Xref=ChEBI CHEBI 18420; Evidence={ECO 0000255|HAMAP-Rule MF_00583, ECO 0000269|PubMed 10954724, ECO 0000269|PubMed 2542328, ECO 0000269|PubMed 3009477, ECO 0000269|PubMed 8679571, ECO 0000269|PubMed 9125530}; Name=Mn(2+); Xref=ChEBI CHEBI 29035; Evidence={ECO 0000255|HAMAP-Rule MF_00583, ECO 0000269|PubMed 10954724, ECO 0000269|PubMed 2542328, ECO 0000269|PubMed 3009477, ECO 0000269|PubMed 8679571, ECO 0000269|PubMed 9125530}; Note=Binds 1 Mg(2+) ion per subunit. Mn(2+) is also accepted. {ECO 0000255|HAMAP-Rule MF_00583, ECO 0000269|PubMed 10954724, ECO 0000269|PubMed 2542328, ECO 0000269|PubMed 3009477, ECO 0000269|PubMed 8679571, ECO 0000269|PubMed 9125530}; # DISRUPTION PHENOTYPE Cells lacking this gene are unable to grow on nucleosides as purine source. {ECO:0000269|PubMed 6290219}. # ENZYME REGULATION KPRS_ECOLI Inhibited by calcium ion, (2',3'-dialdehyde)- ATP (oATP), 1-alpha,2-alpha,3-alpha-trihydroxy-4-beta- cyclopentanemethanol 5-phosphate, alpha,beta-methylene ATP and ADP. {ECO 0000269|PubMed 10954724, ECO 0000269|PubMed 2542328, ECO 0000269|PubMed 3009477, ECO 0000269|PubMed 7657655, ECO 0000269|PubMed 9125530}. # EcoGene EG10774 prs # FUNCTION KPRS_ECOLI Involved in the biosynthesis of ribose 1,5-bisphosphate. Catalyzes the transfer of pyrophosphoryl group from ATP to ribose- 5-phosphate (Rib-5-P) to yield phosphoribosyl diphosphate (PRPP) and AMP. {ECO 0000255|HAMAP-Rule MF_00583, ECO 0000269|PubMed 10954724, ECO 0000269|PubMed 2542328, ECO 0000269|PubMed 3009477, ECO 0000269|PubMed 6290219, ECO 0000269|PubMed 7657655, ECO 0000269|PubMed 8679571, ECO 0000269|PubMed 9125530}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0000287 magnesium ion binding; IDA:EcoCyc. # GO_function GO:0004749 ribose phosphate diphosphokinase activity; IDA:EcoCyc. # GO_function GO:0005524 ATP binding; IEA:UniProtKB-KW. # GO_function GO:0016301 kinase activity; IEA:UniProtKB-KW. # GO_function GO:0042301 phosphate ion binding; IDA:EcoCyc. # GO_process GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process; IMP:EcoCyc. # GO_process GO:0009116 nucleoside metabolic process; IEA:InterPro. # GO_process GO:0009156 ribonucleoside monophosphate biosynthetic process; IEA:UniProtKB-HAMAP. # GO_process GO:0009165 nucleotide biosynthetic process; IEA:UniProtKB-KW. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016301 kinase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0009058 biosynthetic process # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # GOslim_process GO:0044281 small molecule metabolic process # Gene3D 3.40.50.2020 -; 2. # HAMAP MF_00583_B RibP_PPkinase_B # IntAct P0A717 109 # InterPro IPR000836 PRibTrfase_dom # InterPro IPR000842 PRib_PP_synth_CS # InterPro IPR005946 Rib-P_diPkinase # InterPro IPR029057 PRTase-like # InterPro IPR029099 Pribosyltran_N # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko01000 Enzymes # KEGG_Pathway ko00030 Pentose phosphate pathway # KEGG_Pathway ko00230 Purine metabolism # Organism KPRS_ECOLI Escherichia coli (strain K12) # PATHWAY KPRS_ECOLI Metabolic intermediate biosynthesis; 5-phospho-alpha-D- ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1- diphosphate from D-ribose 5-phosphate (route I) step 1/1. {ECO 0000255|HAMAP-Rule MF_00583, ECO 0000269|PubMed 8679571}. # PATRIC 32117666 VBIEscCol129921_1255 # PDB 4S2U X-ray; 2.71 A; A=2-315 # PIR D64867 KIECRY # PROSITE PS00114 PRPP_SYNTHASE # Pfam PF13793 Pribosyltran_N # Pfam PF14572 Pribosyl_synth # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName KPRS_ECOLI Ribose-phosphate pyrophosphokinase {ECO 0000255|HAMAP-Rule MF_00583, ECO 0000303|PubMed 2542328, ECO 0000303|PubMed 3009477, ECO 0000303|PubMed 6290219} # RefSeq NP_415725 NC_000913.3 # RefSeq WP_001298109 NZ_LN832404.1 # SIMILARITY Belongs to the ribose-phosphate pyrophosphokinase family. {ECO:0000255|HAMAP-Rule MF_00583}. # SUBCELLULAR LOCATION KPRS_ECOLI Cytoplasm {ECO 0000255|HAMAP-Rule MF_00583}. # SUPFAM SSF53271 SSF53271 # TIGRFAMs TIGR01251 ribP_PPkin # UniPathway UPA00087 UER00172 # eggNOG COG0462 LUCA # eggNOG ENOG4105C5T Bacteria BLAST swissprot:KPRS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:KPRS_ECOLI BioCyc ECOL316407:JW1198-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1198-MONOMER BioCyc EcoCyc:PRPPSYN-MONOMER http://biocyc.org/getid?id=EcoCyc:PRPPSYN-MONOMER BioCyc MetaCyc:PRPPSYN-MONOMER http://biocyc.org/getid?id=MetaCyc:PRPPSYN-MONOMER COG COG0462 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0462 DIP DIP-35839N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-35839N DOI 10.1002/elps.1150180807 http://dx.doi.org/10.1002/elps.1150180807 DOI 10.1021/bi9528560 http://dx.doi.org/10.1021/bi9528560 DOI 10.1021/bi962610a http://dx.doi.org/10.1021/bi962610a DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1074/jbc.270.35.20730 http://dx.doi.org/10.1074/jbc.270.35.20730 DOI 10.1074/jbc.M006346200 http://dx.doi.org/10.1074/jbc.M006346200 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:2.7.6.1 {ECO:0000255|HAMAP-Rule:MF_00583, ECO:0000269|PubMed:2542328, ECO:0000269|PubMed:3009477, ECO:0000303|PubMed:6290219} http://www.genome.jp/dbget-bin/www_bget?EC:2.7.6.1 {ECO:0000255|HAMAP-Rule:MF_00583, ECO:0000269|PubMed:2542328, ECO:0000269|PubMed:3009477, ECO:0000303|PubMed:6290219} EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M13174 http://www.ebi.ac.uk/ena/data/view/M13174 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 2.7.6.1 {ECO:0000255|HAMAP-Rule:MF_00583, ECO:0000269|PubMed:2542328, ECO:0000269|PubMed:3009477, ECO:0000303|PubMed:6290219} http://enzyme.expasy.org/EC/2.7.6.1 {ECO:0000255|HAMAP-Rule:MF_00583, ECO:0000269|PubMed:2542328, ECO:0000269|PubMed:3009477, ECO:0000303|PubMed:6290219} EchoBASE EB0767 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0767 EcoGene EG10774 http://www.ecogene.org/geneInfo.php?eg_id=EG10774 EnsemblBacteria AAC74291 http://www.ensemblgenomes.org/id/AAC74291 EnsemblBacteria AAC74291 http://www.ensemblgenomes.org/id/AAC74291 EnsemblBacteria BAA36065 http://www.ensemblgenomes.org/id/BAA36065 EnsemblBacteria BAA36065 http://www.ensemblgenomes.org/id/BAA36065 EnsemblBacteria BAA36065 http://www.ensemblgenomes.org/id/BAA36065 EnsemblBacteria b1207 http://www.ensemblgenomes.org/id/b1207 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0000287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000287 GO_function GO:0004749 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004749 GO_function GO:0005524 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005524 GO_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GO_function GO:0042301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042301 GO_process GO:0006015 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006015 GO_process GO:0009116 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009116 GO_process GO:0009156 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009156 GO_process GO:0009165 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009165 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016301 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016301 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 GOslim_process GO:0044281 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044281 Gene3D 3.40.50.2020 http://www.cathdb.info/version/latest/superfamily/3.40.50.2020 GeneID 945772 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945772 HAMAP MF_00583_B http://hamap.expasy.org/unirule/MF_00583_B HOGENOM HOG000210452 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000210452&db=HOGENOM6 InParanoid P0A717 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A717 IntAct P0A717 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A717* IntEnz 2.7.6.1 {ECO:0000255|HAMAP-Rule:MF_00583, ECO:0000269|PubMed:2542328, ECO:0000269|PubMed:3009477, ECO:0000303|PubMed:6290219} http://www.ebi.ac.uk/intenz/query?cmd=Search&q=2.7.6.1 {ECO:0000255|HAMAP-Rule:MF_00583, ECO:0000269|PubMed:2542328, ECO:0000269|PubMed:3009477, ECO:0000303|PubMed:6290219} InterPro IPR000836 http://www.ebi.ac.uk/interpro/entry/IPR000836 InterPro IPR000842 http://www.ebi.ac.uk/interpro/entry/IPR000842 InterPro IPR005946 http://www.ebi.ac.uk/interpro/entry/IPR005946 InterPro IPR029057 http://www.ebi.ac.uk/interpro/entry/IPR029057 InterPro IPR029099 http://www.ebi.ac.uk/interpro/entry/IPR029099 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW1198 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1198 KEGG_Gene eco:b1207 http://www.genome.jp/dbget-bin/www_bget?eco:b1207 KEGG_Orthology KO:K00948 http://www.genome.jp/dbget-bin/www_bget?KO:K00948 KEGG_Pathway ko00030 http://www.genome.jp/kegg-bin/show_pathway?ko00030 KEGG_Pathway ko00230 http://www.genome.jp/kegg-bin/show_pathway?ko00230 KEGG_Reaction rn:R01049 http://www.genome.jp/dbget-bin/www_bget?rn:R01049 MINT MINT-1221689 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1221689 OMA LCLAAQH http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=LCLAAQH PDB 4S2U http://www.ebi.ac.uk/pdbe-srv/view/entry/4S2U PDBsum 4S2U http://www.ebi.ac.uk/pdbsum/4S2U PROSITE PS00114 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00114 PSORT swissprot:KPRS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:KPRS_ECOLI PSORT-B swissprot:KPRS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:KPRS_ECOLI PSORT2 swissprot:KPRS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:KPRS_ECOLI Pfam PF13793 http://pfam.xfam.org/family/PF13793 Pfam PF14572 http://pfam.xfam.org/family/PF14572 Phobius swissprot:KPRS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:KPRS_ECOLI PhylomeDB P0A717 http://phylomedb.org/?seqid=P0A717 ProteinModelPortal P0A717 http://www.proteinmodelportal.org/query/uniprot/P0A717 PubMed 10954724 http://www.ncbi.nlm.nih.gov/pubmed/10954724 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2542328 http://www.ncbi.nlm.nih.gov/pubmed/2542328 PubMed 3009477 http://www.ncbi.nlm.nih.gov/pubmed/3009477 PubMed 6290219 http://www.ncbi.nlm.nih.gov/pubmed/6290219 PubMed 7657655 http://www.ncbi.nlm.nih.gov/pubmed/7657655 PubMed 8679571 http://www.ncbi.nlm.nih.gov/pubmed/8679571 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9125530 http://www.ncbi.nlm.nih.gov/pubmed/9125530 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9298646 http://www.ncbi.nlm.nih.gov/pubmed/9298646 RefSeq NP_415725 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415725 RefSeq WP_001298109 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001298109 SMR P0A717 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A717 STRING 511145.b1207 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1207&targetmode=cogs STRING COG0462 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0462&targetmode=cogs SUPFAM SSF53271 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53271 TIGRFAMs TIGR01251 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR01251 UniProtKB KPRS_ECOLI http://www.uniprot.org/uniprot/KPRS_ECOLI UniProtKB-AC P0A717 http://www.uniprot.org/uniprot/P0A717 charge swissprot:KPRS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:KPRS_ECOLI eggNOG COG0462 http://eggnogapi.embl.de/nog_data/html/tree/COG0462 eggNOG ENOG4105C5T http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C5T epestfind swissprot:KPRS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:KPRS_ECOLI garnier swissprot:KPRS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:KPRS_ECOLI helixturnhelix swissprot:KPRS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:KPRS_ECOLI hmoment swissprot:KPRS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:KPRS_ECOLI iep swissprot:KPRS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:KPRS_ECOLI inforesidue swissprot:KPRS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:KPRS_ECOLI octanol swissprot:KPRS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:KPRS_ECOLI pepcoil swissprot:KPRS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:KPRS_ECOLI pepdigest swissprot:KPRS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:KPRS_ECOLI pepinfo swissprot:KPRS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:KPRS_ECOLI pepnet swissprot:KPRS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:KPRS_ECOLI pepstats swissprot:KPRS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:KPRS_ECOLI pepwheel swissprot:KPRS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:KPRS_ECOLI pepwindow swissprot:KPRS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:KPRS_ECOLI sigcleave swissprot:KPRS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:KPRS_ECOLI ## Database ID URL or Descriptions # BioGrid 4262140 22 # CDD cd06261 TM_PBP2 # EcoGene EG10784 pstC # FUNCTION PSTC_ECOLI Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0005887 integral component of plasma membrane; IBA:GO_Central. # GO_function GO:0005315 inorganic phosphate transmembrane transporter activity; IEA:InterPro. # GO_function GO:0015415 ATPase-coupled phosphate ion transmembrane transporter activity; IDA:EcoCyc. # GO_process GO:0006817 phosphate ion transport; IDA:EcoCyc. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0016887 ATPase activity # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # Gene3D 1.10.3720.10 -; 1. # InterPro IPR000515 MetI-like # InterPro IPR011864 Phosphate_PstC # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko00002 KEGG pathway modules # KEGG_Brite ko02000 M00222 Phosphate transport system # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02010 ABC transporters # Organism PSTC_ECOLI Escherichia coli (strain K12) # PATRIC 32122951 VBIEscCol129921_3851 # PIR H65175 BVECPW # PROSITE PS50928 ABC_TM1 # Pfam PF00528 BPD_transp_1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName PSTC_ECOLI Phosphate transport system permease protein PstC # RefSeq NP_418183 NC_000913.3 # RefSeq WP_000741620 NZ_LN832404.1 # SIMILARITY Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. {ECO 0000305}. # SIMILARITY Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule PRU00441}. # SUBCELLULAR LOCATION PSTC_ECOLI Cell inner membrane; Multi-pass membrane protein. # SUPFAM SSF161098 SSF161098 # TCDB 3.A.1.7 the atp-binding cassette (abc) superfamily # TIGRFAMs TIGR02138 phosphate_pstC # eggNOG COG0573 LUCA # eggNOG ENOG4105C8U Bacteria BLAST swissprot:PSTC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:PSTC_ECOLI BioCyc ECOL316407:JW3705-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3705-MONOMER BioCyc EcoCyc:PSTC-MONOMER http://biocyc.org/getid?id=EcoCyc:PSTC-MONOMER BioCyc MetaCyc:PSTC-MONOMER http://biocyc.org/getid?id=MetaCyc:PSTC-MONOMER COG COG0573 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0573 DOI 10.1006/geno.1993.1230 http://dx.doi.org/10.1006/geno.1993.1230 DOI 10.1016/0022-2836(85)90377-8 http://dx.doi.org/10.1016/0022-2836(85)90377-8 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL K01992 http://www.ebi.ac.uk/ena/data/view/K01992 EMBL L10328 http://www.ebi.ac.uk/ena/data/view/L10328 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X02723 http://www.ebi.ac.uk/ena/data/view/X02723 EchoBASE EB0777 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB0777 EcoGene EG10784 http://www.ecogene.org/geneInfo.php?eg_id=EG10784 EnsemblBacteria AAC76750 http://www.ensemblgenomes.org/id/AAC76750 EnsemblBacteria AAC76750 http://www.ensemblgenomes.org/id/AAC76750 EnsemblBacteria BAE77561 http://www.ensemblgenomes.org/id/BAE77561 EnsemblBacteria BAE77561 http://www.ensemblgenomes.org/id/BAE77561 EnsemblBacteria BAE77561 http://www.ensemblgenomes.org/id/BAE77561 EnsemblBacteria b3727 http://www.ensemblgenomes.org/id/b3727 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0005887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005887 GO_function GO:0005315 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005315 GO_function GO:0015415 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015415 GO_process GO:0006817 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006817 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0016887 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016887 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 Gene3D 1.10.3720.10 http://www.cathdb.info/version/latest/superfamily/1.10.3720.10 GeneID 948238 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948238 HOGENOM HOG000074139 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000074139&db=HOGENOM6 InParanoid P0AGH8 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AGH8 InterPro IPR000515 http://www.ebi.ac.uk/interpro/entry/IPR000515 InterPro IPR011864 http://www.ebi.ac.uk/interpro/entry/IPR011864 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko00002 http://www.genome.jp/dbget-bin/www_bget?ko00002 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW3705 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3705 KEGG_Gene eco:b3727 http://www.genome.jp/dbget-bin/www_bget?eco:b3727 KEGG_Orthology KO:K02037 http://www.genome.jp/dbget-bin/www_bget?KO:K02037 KEGG_Pathway ko02010 http://www.genome.jp/kegg-bin/show_pathway?ko02010 OMA KESAYGV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=KESAYGV PROSITE PS50928 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50928 PSORT swissprot:PSTC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:PSTC_ECOLI PSORT-B swissprot:PSTC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:PSTC_ECOLI PSORT2 swissprot:PSTC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:PSTC_ECOLI Pfam PF00528 http://pfam.xfam.org/family/PF00528 Phobius swissprot:PSTC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:PSTC_ECOLI PhylomeDB P0AGH8 http://phylomedb.org/?seqid=P0AGH8 ProteinModelPortal P0AGH8 http://www.proteinmodelportal.org/query/uniprot/P0AGH8 PubMed 1447208 http://www.ncbi.nlm.nih.gov/pubmed/1447208 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2993631 http://www.ncbi.nlm.nih.gov/pubmed/2993631 PubMed 3881386 http://www.ncbi.nlm.nih.gov/pubmed/3881386 PubMed 7686882 http://www.ncbi.nlm.nih.gov/pubmed/7686882 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_418183 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_418183 RefSeq WP_000741620 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000741620 STRING 511145.b3727 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3727&targetmode=cogs STRING COG0573 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0573&targetmode=cogs SUPFAM SSF161098 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF161098 TCDB 3.A.1.7 http://www.tcdb.org/search/result.php?tc=3.A.1.7 TIGRFAMs TIGR02138 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02138 UniProtKB PSTC_ECOLI http://www.uniprot.org/uniprot/PSTC_ECOLI UniProtKB-AC P0AGH8 http://www.uniprot.org/uniprot/P0AGH8 charge swissprot:PSTC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:PSTC_ECOLI eggNOG COG0573 http://eggnogapi.embl.de/nog_data/html/tree/COG0573 eggNOG ENOG4105C8U http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105C8U epestfind swissprot:PSTC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:PSTC_ECOLI garnier swissprot:PSTC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:PSTC_ECOLI helixturnhelix swissprot:PSTC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:PSTC_ECOLI hmoment swissprot:PSTC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:PSTC_ECOLI iep swissprot:PSTC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:PSTC_ECOLI inforesidue swissprot:PSTC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:PSTC_ECOLI octanol swissprot:PSTC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:PSTC_ECOLI pepcoil swissprot:PSTC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:PSTC_ECOLI pepdigest swissprot:PSTC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:PSTC_ECOLI pepinfo swissprot:PSTC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:PSTC_ECOLI pepnet swissprot:PSTC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:PSTC_ECOLI pepstats swissprot:PSTC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:PSTC_ECOLI pepwheel swissprot:PSTC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:PSTC_ECOLI pepwindow swissprot:PSTC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:PSTC_ECOLI sigcleave swissprot:PSTC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:PSTC_ECOLI ## Database ID URL or Descriptions # BRENDA 3.1.2 2026 # BioGrid 4259452 197 # EcoGene EG11110 ybgC # FUNCTION YBGC_ECOLI Thioesterase that appears to be involved in phospholipid metabolism. Some specific acyl-ACPs could be physiological substrates. Displays acyl-CoA thioesterase activity on malonyl-CoA in vitro, catalyzing the hydrolysis of the thioester bond. {ECO 0000269|PubMed 16294310}. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_function GO:0016790 thiolester hydrolase activity; IDA:EcoCyc. # GO_process GO:0006629 lipid metabolic process; IEA:UniProtKB-KW. # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_process GO:0006629 lipid metabolic process # Gene3D 3.10.129.10 -; 1. # INTERACTION YBGC_ECOLI P0A6A8 acpP; NbExp=6; IntAct=EBI-543276, EBI-542566; O32591 espP (xeno); NbExp=2; IntAct=EBI-543276, EBI-852989; P10408 secA; NbExp=2; IntAct=EBI-543276, EBI-543213; # IntAct P0A8Z3 11 # InterPro IPR006683 Thioestr_dom # InterPro IPR006684 YbgC/YbaW # InterPro IPR008272 HB-CoA_thioesterase_AS # InterPro IPR014166 Tol-Pal_acyl-CoA_thioesterase # InterPro IPR029069 HotDog_dom # KEGG_Brite ko01000 Enzymes # Organism YBGC_ECOLI Escherichia coli (strain K12) # PATRIC 32116671 VBIEscCol129921_0768 # PDB 1S5U X-ray; 1.70 A; A/B/C/D/E/F/G/H=1-134 # PDB 5KL9 X-ray; 2.22 A; A/B/C/D=1-134 # PDB 5T06 X-ray; 1.90 A; A/B/C/D=2-134 # PDB 5T07 X-ray; 1.72 A; A/B/C/D=2-134 # PIR A25980 WMEC15 # PIRSF PIRSF003230 YbgC # PROSITE PS01328 4HBCOA_THIOESTERASE # Pfam PF03061 4HBT # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YBGC_ECOLI Acyl-CoA thioester hydrolase YbgC # RefSeq NP_415264 NC_000913.3 # RefSeq WP_001098384 NZ_LN832404.1 # SIMILARITY Belongs to the 4-hydroxybenzoyl-CoA thioesterase family. {ECO 0000305}. # SUBCELLULAR LOCATION YBGC_ECOLI Cell inner membrane {ECO 0000269|PubMed 16294310}; Peripheral membrane protein {ECO 0000269|PubMed 16294310}; Cytoplasmic side {ECO 0000269|PubMed 16294310}. # SUBUNIT Interacts with ACP, PlsB and PssA, forming altogether a complex at the inner membrane. {ECO:0000269|PubMed 16294310}. # SUPFAM SSF54637 SSF54637 # TIGRFAMs TIGR00051 TIGR00051 # TIGRFAMs TIGR02799 thio_ybgC # eggNOG COG0824 LUCA # eggNOG ENOG4107YD3 Bacteria BLAST swissprot:YBGC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YBGC_ECOLI BioCyc ECOL316407:JW0726-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0726-MONOMER BioCyc EcoCyc:EG11110-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11110-MONOMER COG COG0824 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0824 DIP DIP-29375N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-29375N DOI 10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO http://dx.doi.org/10.1002/(SICI)1522-2683(19990801)20:11<2181::AID-ELPS2181>3.0.CO DOI 10.1002/pmic.200500115 http://dx.doi.org/10.1002/pmic.200500115 DOI 10.1016/j.fmrre.2004.12.006 http://dx.doi.org/10.1016/j.fmrre.2004.12.006 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:3.1.2.- http://www.genome.jp/dbget-bin/www_bget?EC:3.1.2.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M16489 http://www.ebi.ac.uk/ena/data/view/M16489 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U30934 http://www.ebi.ac.uk/ena/data/view/U30934 ENZYME 3.1.2.- http://enzyme.expasy.org/EC/3.1.2.- EchoBASE EB1101 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1101 EcoGene EG11110 http://www.ecogene.org/geneInfo.php?eg_id=EG11110 EnsemblBacteria AAC73830 http://www.ensemblgenomes.org/id/AAC73830 EnsemblBacteria AAC73830 http://www.ensemblgenomes.org/id/AAC73830 EnsemblBacteria BAA35402 http://www.ensemblgenomes.org/id/BAA35402 EnsemblBacteria BAA35402 http://www.ensemblgenomes.org/id/BAA35402 EnsemblBacteria BAA35402 http://www.ensemblgenomes.org/id/BAA35402 EnsemblBacteria b0736 http://www.ensemblgenomes.org/id/b0736 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_function GO:0016790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016790 GO_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 Gene3D 3.10.129.10 http://www.cathdb.info/version/latest/superfamily/3.10.129.10 GeneID 948907 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=948907 HOGENOM HOG000004132 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000004132&db=HOGENOM6 InParanoid P0A8Z3 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0A8Z3 IntAct P0A8Z3 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P0A8Z3* IntEnz 3.1.2 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=3.1.2 InterPro IPR006683 http://www.ebi.ac.uk/interpro/entry/IPR006683 InterPro IPR006684 http://www.ebi.ac.uk/interpro/entry/IPR006684 InterPro IPR008272 http://www.ebi.ac.uk/interpro/entry/IPR008272 InterPro IPR014166 http://www.ebi.ac.uk/interpro/entry/IPR014166 InterPro IPR029069 http://www.ebi.ac.uk/interpro/entry/IPR029069 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW0726 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0726 KEGG_Gene eco:b0736 http://www.genome.jp/dbget-bin/www_bget?eco:b0736 KEGG_Orthology KO:K07107 http://www.genome.jp/dbget-bin/www_bget?KO:K07107 MINT MINT-1222012 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1222012 OMA ELGFAQS http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=ELGFAQS PDB 1S5U http://www.ebi.ac.uk/pdbe-srv/view/entry/1S5U PDB 5KL9 http://www.ebi.ac.uk/pdbe-srv/view/entry/5KL9 PDB 5T06 http://www.ebi.ac.uk/pdbe-srv/view/entry/5T06 PDB 5T07 http://www.ebi.ac.uk/pdbe-srv/view/entry/5T07 PDBsum 1S5U http://www.ebi.ac.uk/pdbsum/1S5U PDBsum 5KL9 http://www.ebi.ac.uk/pdbsum/5KL9 PDBsum 5T06 http://www.ebi.ac.uk/pdbsum/5T06 PDBsum 5T07 http://www.ebi.ac.uk/pdbsum/5T07 PROSITE PS01328 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01328 PSORT swissprot:YBGC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YBGC_ECOLI PSORT-B swissprot:YBGC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YBGC_ECOLI PSORT2 swissprot:YBGC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YBGC_ECOLI Pfam PF03061 http://pfam.xfam.org/family/PF03061 Phobius swissprot:YBGC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YBGC_ECOLI PhylomeDB P0A8Z3 http://phylomedb.org/?seqid=P0A8Z3 ProteinModelPortal P0A8Z3 http://www.proteinmodelportal.org/query/uniprot/P0A8Z3 PubMed 10493123 http://www.ncbi.nlm.nih.gov/pubmed/10493123 PubMed 15808744 http://www.ncbi.nlm.nih.gov/pubmed/15808744 PubMed 16294310 http://www.ncbi.nlm.nih.gov/pubmed/16294310 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 3294803 http://www.ncbi.nlm.nih.gov/pubmed/3294803 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415264 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415264 RefSeq WP_001098384 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001098384 SMR P0A8Z3 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0A8Z3 STRING 511145.b0736 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0736&targetmode=cogs STRING COG0824 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0824&targetmode=cogs SUPFAM SSF54637 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF54637 TIGRFAMs TIGR00051 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00051 TIGRFAMs TIGR02799 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02799 UniProtKB YBGC_ECOLI http://www.uniprot.org/uniprot/YBGC_ECOLI UniProtKB-AC P0A8Z3 http://www.uniprot.org/uniprot/P0A8Z3 charge swissprot:YBGC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YBGC_ECOLI eggNOG COG0824 http://eggnogapi.embl.de/nog_data/html/tree/COG0824 eggNOG ENOG4107YD3 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107YD3 epestfind swissprot:YBGC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YBGC_ECOLI garnier swissprot:YBGC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YBGC_ECOLI helixturnhelix swissprot:YBGC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YBGC_ECOLI hmoment swissprot:YBGC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YBGC_ECOLI iep swissprot:YBGC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YBGC_ECOLI inforesidue swissprot:YBGC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YBGC_ECOLI octanol swissprot:YBGC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YBGC_ECOLI pepcoil swissprot:YBGC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YBGC_ECOLI pepdigest swissprot:YBGC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YBGC_ECOLI pepinfo swissprot:YBGC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YBGC_ECOLI pepnet swissprot:YBGC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YBGC_ECOLI pepstats swissprot:YBGC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YBGC_ECOLI pepwheel swissprot:YBGC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YBGC_ECOLI pepwindow swissprot:YBGC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YBGC_ECOLI sigcleave swissprot:YBGC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YBGC_ECOLI ## Database ID URL or Descriptions # CDD cd06257 DnaJ # EcoGene EG13649 djlB # Gene3D 1.10.287.110 -; 1. # InterPro IPR001623 DnaJ_domain # Organism DJLB_ECOLI Escherichia coli (strain K12) # PATRIC 32116475 VBIEscCol129921_0677 # PIR D64799 D64799 # PROSITE PS50076 DNAJ_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName DJLB_ECOLI Uncharacterized J domain-containing protein DjlB # RefSeq NP_415179 NC_000913.3 # RefSeq WP_000786572 NZ_LN832404.1 # SIMILARITY Contains 1 J domain. {ECO:0000255|PROSITE- ProRule PRU00286}. # SMART SM00271 DnaJ # SUPFAM SSF46565 SSF46565 # eggNOG ENOG4105QFC Bacteria # eggNOG ENOG4111WD0 LUCA BLAST swissprot:DJLB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:DJLB_ECOLI BioCyc ECOL316407:JW0641-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0641-MONOMER BioCyc EcoCyc:G6353-MONOMER http://biocyc.org/getid?id=EcoCyc:G6353-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB3413 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3413 EcoGene EG13649 http://www.ecogene.org/geneInfo.php?eg_id=EG13649 EnsemblBacteria AAC73747 http://www.ensemblgenomes.org/id/AAC73747 EnsemblBacteria AAC73747 http://www.ensemblgenomes.org/id/AAC73747 EnsemblBacteria BAA35293 http://www.ensemblgenomes.org/id/BAA35293 EnsemblBacteria BAA35293 http://www.ensemblgenomes.org/id/BAA35293 EnsemblBacteria BAA35293 http://www.ensemblgenomes.org/id/BAA35293 EnsemblBacteria b0646 http://www.ensemblgenomes.org/id/b0646 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv Gene3D 1.10.287.110 http://www.cathdb.info/version/latest/superfamily/1.10.287.110 GeneID 945245 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945245 HOGENOM HOG000009369 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000009369&db=HOGENOM6 IntAct P77381 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77381* InterPro IPR001623 http://www.ebi.ac.uk/interpro/entry/IPR001623 KEGG_Gene ecj:JW0641 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0641 KEGG_Gene eco:b0646 http://www.genome.jp/dbget-bin/www_bget?eco:b0646 OMA PGCLGVI http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=PGCLGVI PROSITE PS50076 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50076 PSORT swissprot:DJLB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:DJLB_ECOLI PSORT-B swissprot:DJLB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:DJLB_ECOLI PSORT2 swissprot:DJLB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:DJLB_ECOLI Phobius swissprot:DJLB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:DJLB_ECOLI ProteinModelPortal P77381 http://www.proteinmodelportal.org/query/uniprot/P77381 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415179 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415179 RefSeq WP_000786572 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000786572 SMART SM00271 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00271 SMR P77381 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77381 STRING 511145.b0646 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0646&targetmode=cogs SUPFAM SSF46565 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF46565 UniProtKB DJLB_ECOLI http://www.uniprot.org/uniprot/DJLB_ECOLI UniProtKB-AC P77381 http://www.uniprot.org/uniprot/P77381 charge swissprot:DJLB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:DJLB_ECOLI eggNOG ENOG4105QFC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105QFC eggNOG ENOG4111WD0 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4111WD0 epestfind swissprot:DJLB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:DJLB_ECOLI garnier swissprot:DJLB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:DJLB_ECOLI helixturnhelix swissprot:DJLB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:DJLB_ECOLI hmoment swissprot:DJLB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:DJLB_ECOLI iep swissprot:DJLB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:DJLB_ECOLI inforesidue swissprot:DJLB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:DJLB_ECOLI octanol swissprot:DJLB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:DJLB_ECOLI pepcoil swissprot:DJLB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:DJLB_ECOLI pepdigest swissprot:DJLB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:DJLB_ECOLI pepinfo swissprot:DJLB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:DJLB_ECOLI pepnet swissprot:DJLB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:DJLB_ECOLI pepstats swissprot:DJLB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:DJLB_ECOLI pepwheel swissprot:DJLB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:DJLB_ECOLI pepwindow swissprot:DJLB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:DJLB_ECOLI sigcleave swissprot:DJLB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:DJLB_ECOLI ## Database ID URL or Descriptions # AltName INSB4_ECOLI IS1d # EcoGene EG40002 insB4 # FUNCTION INSB4_ECOLI Absolutely required for transposition of IS1. # GO_function GO:0003677 DNA binding; IEA:InterPro. # GO_function GO:0004803 transposase activity; IEA:InterPro. # GO_process GO:0006313 transposition, DNA-mediated; IMP:EcoCyc. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0003677 DNA binding # GOslim_process GO:0006259 DNA metabolic process # GOslim_process GO:0032196 transposition # IntAct P57998 2 # InterPro IPR005063 Transposase_27 # Organism INSB4_ECOLI Escherichia coli (strain K12) # PATRIC 32117201 VBIEscCol129921_1024 # Pfam PF03400 DDE_Tnp_IS1 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName INSB4_ECOLI Insertion element IS1 4 protein InsB # RefSeq NP_415508 NC_000913.3 # RefSeq WP_001119339 NZ_LN832404.1 # SIMILARITY Belongs to the transposase 27 family. {ECO 0000305}. # eggNOG COG1662 LUCA BLAST swissprot:INSB4_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:INSB4_ECOLI BioCyc ECOL316407:JW0972-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0972-MONOMER BioCyc EcoCyc:G6509-MONOMER http://biocyc.org/getid?id=EcoCyc:G6509-MONOMER COG COG1662 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1662 DOI 10.1016/0378-1119(91)90096-T http://dx.doi.org/10.1016/0378-1119(91)90096-T DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL X52536 http://www.ebi.ac.uk/ena/data/view/X52536 EchoBASE EB4719 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4719 EcoGene EG40002 http://www.ecogene.org/geneInfo.php?eg_id=EG40002 EnsemblBacteria AAC74073 http://www.ensemblgenomes.org/id/AAC74073 EnsemblBacteria AAC74073 http://www.ensemblgenomes.org/id/AAC74073 EnsemblBacteria BAA35754 http://www.ensemblgenomes.org/id/BAA35754 EnsemblBacteria BAA35754 http://www.ensemblgenomes.org/id/BAA35754 EnsemblBacteria BAA35754 http://www.ensemblgenomes.org/id/BAA35754 EnsemblBacteria b0988 http://www.ensemblgenomes.org/id/b0988 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GO_function GO:0004803 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004803 GO_process GO:0006313 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006313 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0003677 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677 GOslim_process GO:0006259 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006259 GOslim_process GO:0032196 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032196 GeneID 945009 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945009 HOGENOM HOG000036821 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000036821&db=HOGENOM6 InParanoid P57998 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P57998 IntAct P57998 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P57998* InterPro IPR005063 http://www.ebi.ac.uk/interpro/entry/IPR005063 KEGG_Gene ecj:JW0972 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0972 KEGG_Gene eco:b0988 http://www.genome.jp/dbget-bin/www_bget?eco:b0988 KEGG_Orthology KO:K07480 http://www.genome.jp/dbget-bin/www_bget?KO:K07480 OMA VCAKSRQ http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=VCAKSRQ PSORT swissprot:INSB4_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:INSB4_ECOLI PSORT-B swissprot:INSB4_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:INSB4_ECOLI PSORT2 swissprot:INSB4_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:INSB4_ECOLI Pfam PF03400 http://pfam.xfam.org/family/PF03400 Phobius swissprot:INSB4_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:INSB4_ECOLI PhylomeDB P57998 http://phylomedb.org/?seqid=P57998 ProteinModelPortal P57998 http://www.proteinmodelportal.org/query/uniprot/P57998 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 1849492 http://www.ncbi.nlm.nih.gov/pubmed/1849492 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415508 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415508 RefSeq WP_001119339 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001119339 STRING 511145.b0988 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0988&targetmode=cogs STRING COG1662 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1662&targetmode=cogs UniProtKB INSB4_ECOLI http://www.uniprot.org/uniprot/INSB4_ECOLI UniProtKB-AC P57998 http://www.uniprot.org/uniprot/P57998 charge swissprot:INSB4_ECOLI http://rest.g-language.org/emboss/charge/swissprot:INSB4_ECOLI eggNOG COG1662 http://eggnogapi.embl.de/nog_data/html/tree/COG1662 epestfind swissprot:INSB4_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:INSB4_ECOLI garnier swissprot:INSB4_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:INSB4_ECOLI helixturnhelix swissprot:INSB4_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:INSB4_ECOLI hmoment swissprot:INSB4_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:INSB4_ECOLI iep swissprot:INSB4_ECOLI http://rest.g-language.org/emboss/iep/swissprot:INSB4_ECOLI inforesidue swissprot:INSB4_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:INSB4_ECOLI octanol swissprot:INSB4_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:INSB4_ECOLI pepcoil swissprot:INSB4_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:INSB4_ECOLI pepdigest swissprot:INSB4_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:INSB4_ECOLI pepinfo swissprot:INSB4_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:INSB4_ECOLI pepnet swissprot:INSB4_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:INSB4_ECOLI pepstats swissprot:INSB4_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:INSB4_ECOLI pepwheel swissprot:INSB4_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:INSB4_ECOLI pepwindow swissprot:INSB4_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:INSB4_ECOLI sigcleave swissprot:INSB4_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:INSB4_ECOLI ## Database ID URL or Descriptions # BioGrid 4261269 140 # EcoGene EG12914 yhfS # GO_component GO:0005737 cytoplasm; IBA:GO_Central. # GO_function GO:0003961 O-acetylhomoserine aminocarboxypropyltransferase activity; IBA:GO_Central. # GO_function GO:0003962 cystathionine gamma-synthase activity; IBA:GO_Central. # GO_function GO:0004123 cystathionine gamma-lyase activity; IBA:GO_Central. # GO_function GO:0004124 cysteine synthase activity; IBA:GO_Central. # GO_function GO:0030170 pyridoxal phosphate binding; IBA:GO_Central. # GO_process GO:0019343 cysteine biosynthetic process via cystathionine; IBA:GO_Central. # GO_process GO:0019346 transsulfuration; IBA:GO_Central. # GO_process GO:0071266 'de novo' L-methionine biosynthetic process; IBA:GO_Central. # GOslim_component GO:0005737 cytoplasm # GOslim_function GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups # GOslim_function GO:0016829 lyase activity # GOslim_function GO:0043167 ion binding # GOslim_process GO:0006520 cellular amino acid metabolic process # GOslim_process GO:0006790 sulfur compound metabolic process # GOslim_process GO:0009058 biosynthetic process # Gene3D 3.40.640.10 -; 1. # IntAct P45545 5 # InterPro IPR004839 Aminotransferase_I/II # InterPro IPR015421 PyrdxlP-dep_Trfase_major_sub1 # InterPro IPR015424 PyrdxlP-dep_Trfase # Organism YHFS_ECOLI Escherichia coli (strain K12) # PATRIC 32122184 VBIEscCol129921_3469 # PDB 4J8L X-ray; 1.65 A; A=2-361 # PIR C65132 C65132 # Pfam PF00155 Aminotran_1_2 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHFS_ECOLI Uncharacterized protein YhfS # RefSeq NP_417835 NC_000913.3 # RefSeq WP_000847144 NZ_LN832404.1 # SUPFAM SSF53383 SSF53383 # eggNOG ENOG4106PKC Bacteria # eggNOG ENOG410Z1QN LUCA BLAST swissprot:YHFS_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHFS_ECOLI BioCyc ECOL316407:JW3339-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3339-MONOMER BioCyc EcoCyc:G7728-MONOMER http://biocyc.org/getid?id=EcoCyc:G7728-MONOMER DIP DIP-12328N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-12328N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18997 http://www.ebi.ac.uk/ena/data/view/U18997 EchoBASE EB2750 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2750 EcoGene EG12914 http://www.ecogene.org/geneInfo.php?eg_id=EG12914 EnsemblBacteria AAC76401 http://www.ensemblgenomes.org/id/AAC76401 EnsemblBacteria AAC76401 http://www.ensemblgenomes.org/id/AAC76401 EnsemblBacteria BAE77915 http://www.ensemblgenomes.org/id/BAE77915 EnsemblBacteria BAE77915 http://www.ensemblgenomes.org/id/BAE77915 EnsemblBacteria BAE77915 http://www.ensemblgenomes.org/id/BAE77915 EnsemblBacteria b3376 http://www.ensemblgenomes.org/id/b3376 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GO_function GO:0003961 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003961 GO_function GO:0003962 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003962 GO_function GO:0004123 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004123 GO_function GO:0004124 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004124 GO_function GO:0030170 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030170 GO_process GO:0019343 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019343 GO_process GO:0019346 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019346 GO_process GO:0071266 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071266 GOslim_component GO:0005737 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005737 GOslim_function GO:0016765 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016765 GOslim_function GO:0016829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 GOslim_process GO:0006520 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006520 GOslim_process GO:0006790 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006790 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 Gene3D 3.40.640.10 http://www.cathdb.info/version/latest/superfamily/3.40.640.10 GeneID 947884 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=947884 HOGENOM HOG000125442 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000125442&db=HOGENOM6 IntAct P45545 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P45545* InterPro IPR004839 http://www.ebi.ac.uk/interpro/entry/IPR004839 InterPro IPR015421 http://www.ebi.ac.uk/interpro/entry/IPR015421 InterPro IPR015424 http://www.ebi.ac.uk/interpro/entry/IPR015424 KEGG_Gene ecj:JW3339 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3339 KEGG_Gene eco:b3376 http://www.genome.jp/dbget-bin/www_bget?eco:b3376 OMA RMIRINP http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RMIRINP PDB 4J8L http://www.ebi.ac.uk/pdbe-srv/view/entry/4J8L PDBsum 4J8L http://www.ebi.ac.uk/pdbsum/4J8L PSORT swissprot:YHFS_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHFS_ECOLI PSORT-B swissprot:YHFS_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHFS_ECOLI PSORT2 swissprot:YHFS_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHFS_ECOLI Pfam PF00155 http://pfam.xfam.org/family/PF00155 Phobius swissprot:YHFS_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHFS_ECOLI ProteinModelPortal P45545 http://www.proteinmodelportal.org/query/uniprot/P45545 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_417835 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_417835 RefSeq WP_000847144 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000847144 SMR P45545 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P45545 STRING 511145.b3376 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b3376&targetmode=cogs SUPFAM SSF53383 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53383 UniProtKB YHFS_ECOLI http://www.uniprot.org/uniprot/YHFS_ECOLI UniProtKB-AC P45545 http://www.uniprot.org/uniprot/P45545 charge swissprot:YHFS_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHFS_ECOLI eggNOG ENOG4106PKC http://eggnogapi.embl.de/nog_data/html/tree/ENOG4106PKC eggNOG ENOG410Z1QN http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Z1QN epestfind swissprot:YHFS_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHFS_ECOLI garnier swissprot:YHFS_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHFS_ECOLI helixturnhelix swissprot:YHFS_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHFS_ECOLI hmoment swissprot:YHFS_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHFS_ECOLI iep swissprot:YHFS_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHFS_ECOLI inforesidue swissprot:YHFS_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHFS_ECOLI octanol swissprot:YHFS_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHFS_ECOLI pepcoil swissprot:YHFS_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHFS_ECOLI pepdigest swissprot:YHFS_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHFS_ECOLI pepinfo swissprot:YHFS_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHFS_ECOLI pepnet swissprot:YHFS_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHFS_ECOLI pepstats swissprot:YHFS_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHFS_ECOLI pepwheel swissprot:YHFS_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHFS_ECOLI pepwindow swissprot:YHFS_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHFS_ECOLI sigcleave swissprot:YHFS_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHFS_ECOLI ## Database ID URL or Descriptions # BioGrid 4261358 165 # EcoGene EG11982 rfc # FUNCTION RFC_ECOLI May link the O-antigen tetrasaccharide units into long chains, giving rise to typical smooth LPS. # GO_component GO:0005886 plasma membrane; IDA:EcoCyc. # GO_component GO:0016021 integral component of membrane; IEA:UniProtKB-KW. # GO_process GO:0009103 lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniPathway. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_process GO:0005975 carbohydrate metabolic process # GOslim_process GO:0006629 lipid metabolic process # GOslim_process GO:0009058 biosynthetic process # KEGG_Brite ko01005 Lipopolysaccharide biosynthesis proteins # Organism RFC_ECOLI Escherichia coli (strain K12) # PATHWAY RFC_ECOLI Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. # PATRIC 32119403 VBIEscCol129921_2111 # PIR I69644 I69644 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RFC_ECOLI O-antigen polymerase # RefSeq NP_416539 NC_000913.3 # RefSeq WP_000639866 NZ_LN832404.1 # SUBCELLULAR LOCATION RFC_ECOLI Cell inner membrane {ECO 0000269|PubMed 15919996}; Multi-pass membrane protein {ECO 0000269|PubMed 15919996}. # TCDB 9.B.67.2 the putative inorganic carbon (hco3(-)) transporter/o-antigen polymerase (ict/oap) family # eggNOG ENOG4107B0W Bacteria # eggNOG ENOG410Z7XC LUCA BLAST swissprot:RFC_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RFC_ECOLI BioCyc ECOL316407:JW2020-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2020-MONOMER BioCyc EcoCyc:EG11982-MONOMER http://biocyc.org/getid?id=EcoCyc:EG11982-MONOMER DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.379 http://dx.doi.org/10.1093/dnares/3.6.379 DOI 10.1126/science.1109730 http://dx.doi.org/10.1126/science.1109730 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U03041 http://www.ebi.ac.uk/ena/data/view/U03041 EMBL U09876 http://www.ebi.ac.uk/ena/data/view/U09876 EchoBASE EB1925 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB1925 EcoGene EG11982 http://www.ecogene.org/geneInfo.php?eg_id=EG11982 EnsemblBacteria AAC75096 http://www.ensemblgenomes.org/id/AAC75096 EnsemblBacteria AAC75096 http://www.ensemblgenomes.org/id/AAC75096 EnsemblBacteria BAA15877 http://www.ensemblgenomes.org/id/BAA15877 EnsemblBacteria BAA15877 http://www.ensemblgenomes.org/id/BAA15877 EnsemblBacteria BAA15877 http://www.ensemblgenomes.org/id/BAA15877 EnsemblBacteria b2035 http://www.ensemblgenomes.org/id/b2035 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_process GO:0009103 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009103 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_process GO:0005975 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005975 GOslim_process GO:0006629 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006629 GOslim_process GO:0009058 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058 GeneID 945179 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945179 KEGG_Brite ko01005 http://www.genome.jp/dbget-bin/www_bget?ko01005 KEGG_Gene ecj:JW2020 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2020 KEGG_Gene eco:b2035 http://www.genome.jp/dbget-bin/www_bget?eco:b2035 KEGG_Orthology KO:K13008 http://www.genome.jp/dbget-bin/www_bget?KO:K13008 OMA TWNLEVY http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TWNLEVY PSORT swissprot:RFC_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RFC_ECOLI PSORT-B swissprot:RFC_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RFC_ECOLI PSORT2 swissprot:RFC_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RFC_ECOLI Phobius swissprot:RFC_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RFC_ECOLI ProteinModelPortal P37748 http://www.proteinmodelportal.org/query/uniprot/P37748 PubMed 15919996 http://www.ncbi.nlm.nih.gov/pubmed/15919996 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 7517390 http://www.ncbi.nlm.nih.gov/pubmed/7517390 PubMed 7517391 http://www.ncbi.nlm.nih.gov/pubmed/7517391 PubMed 9097040 http://www.ncbi.nlm.nih.gov/pubmed/9097040 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416539 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416539 RefSeq WP_000639866 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000639866 STRING 511145.b2035 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2035&targetmode=cogs TCDB 9.B.67.2 http://www.tcdb.org/search/result.php?tc=9.B.67.2 UniProtKB RFC_ECOLI http://www.uniprot.org/uniprot/RFC_ECOLI UniProtKB-AC P37748 http://www.uniprot.org/uniprot/P37748 charge swissprot:RFC_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RFC_ECOLI eggNOG ENOG4107B0W http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107B0W eggNOG ENOG410Z7XC http://eggnogapi.embl.de/nog_data/html/tree/ENOG410Z7XC epestfind swissprot:RFC_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RFC_ECOLI garnier swissprot:RFC_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RFC_ECOLI helixturnhelix swissprot:RFC_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RFC_ECOLI hmoment swissprot:RFC_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RFC_ECOLI iep swissprot:RFC_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RFC_ECOLI inforesidue swissprot:RFC_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RFC_ECOLI octanol swissprot:RFC_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RFC_ECOLI pepcoil swissprot:RFC_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RFC_ECOLI pepdigest swissprot:RFC_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RFC_ECOLI pepinfo swissprot:RFC_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RFC_ECOLI pepnet swissprot:RFC_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RFC_ECOLI pepstats swissprot:RFC_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RFC_ECOLI pepwheel swissprot:RFC_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RFC_ECOLI pepwindow swissprot:RFC_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RFC_ECOLI sigcleave swissprot:RFC_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RFC_ECOLI ## Database ID URL or Descriptions # AltName RLUB_ECOLI 23S rRNA pseudouridine(2605) synthase # AltName RLUB_ECOLI rRNA pseudouridylate synthase B # AltName RLUB_ECOLI rRNA-uridine isomerase B # BRENDA 5.4.99.22 2026 # BioGrid 4259574 10 # CATALYTIC ACTIVITY 23S rRNA uridine(2605) = 23S rRNA pseudouridine(2605). {ECO:0000269|PubMed 11720289}. # EcoGene EG12433 rluB # FUNCTION RLUB_ECOLI Responsible for synthesis of pseudouridine from uracil- 2605 in 23S ribosomal RNA. {ECO 0000269|PubMed 11720289}. # GO_component GO:0005829 cytosol; IDA:EcoCyc. # GO_function GO:0003723 RNA binding; IEA:UniProtKB-KW. # GO_function GO:0009982 pseudouridine synthase activity; IMP:EcoCyc. # GO_process GO:0000455 enzyme-directed rRNA pseudouridine synthesis; IMP:EcoCyc. # GOslim_component GO:0005829 cytosol # GOslim_function GO:0003723 RNA binding # GOslim_function GO:0016853 isomerase activity # GOslim_process GO:0034641 cellular nitrogen compound metabolic process # Gene3D 3.10.290.10 -; 1. # INTERACTION RLUB_ECOLI P02359 rpsG; NbExp=3; IntAct=EBI-561550, EBI-543074; P21507 srmB; NbExp=4; IntAct=EBI-561550, EBI-546628; # IntAct P37765 76 # InterPro IPR000748 PsdUridine_synth_RsuA/RluB/E/F # InterPro IPR002942 S4_RNA-bd # InterPro IPR006145 PsdUridine_synth_RsuA/RluD # InterPro IPR018496 PsdUridine_synth_RsuA/RluB_CS # InterPro IPR020103 PsdUridine_synth_cat_dom # KEGG_Brite ko01000 Enzymes # KEGG_Brite ko03009 Ribosome biogenesis # Organism RLUB_ECOLI Escherichia coli (strain K12) # PATRIC 32117796 VBIEscCol129921_1318 # PDB 4LAB X-ray; 2.50 A; A=1-251 # PDB 4LGT X-ray; 1.30 A; A/D=1-251 # PIR H64874 H64874 # PROSITE PS01149 PSI_RSU # PROSITE PS50889 S4 # Pfam PF00849 PseudoU_synth_2 # Pfam PF01479 S4 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName RLUB_ECOLI Ribosomal large subunit pseudouridine synthase B # RefSeq NP_415785 NC_000913.3 # RefSeq WP_001291217 NZ_LN832404.1 # SEQUENCE CAUTION Sequence=M21528; Type=Frameshift; Positions=228; Evidence={ECO 0000305}; # SIMILARITY Belongs to the pseudouridine synthase RsuA family. {ECO 0000305}. # SIMILARITY Contains 1 S4 RNA-binding domain. {ECO:0000255|PROSITE-ProRule PRU00182}. # SMART SM00363 S4 # SUPFAM SSF55120 SSF55120 # TIGRFAMs TIGR00093 TIGR00093 # eggNOG COG1187 LUCA # eggNOG ENOG4105FE9 Bacteria BLAST swissprot:RLUB_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:RLUB_ECOLI BioCyc ECOL316407:JW1261-MONOMER http://biocyc.org/getid?id=ECOL316407:JW1261-MONOMER BioCyc EcoCyc:EG12433-MONOMER http://biocyc.org/getid?id=EcoCyc:EG12433-MONOMER BioCyc MetaCyc:EG12433-MONOMER http://biocyc.org/getid?id=MetaCyc:EG12433-MONOMER COG COG1187 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1187 DIP DIP-11585N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-11585N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.6.363 http://dx.doi.org/10.1093/dnares/3.6.363 DOI 10.1093/nar/22.22.4756 http://dx.doi.org/10.1093/nar/22.22.4756 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:5.4.99.22 http://www.genome.jp/dbget-bin/www_bget?EC:5.4.99.22 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M21528 http://www.ebi.ac.uk/ena/data/view/M21528 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U18111 http://www.ebi.ac.uk/ena/data/view/U18111 ENZYME 5.4.99.22 http://enzyme.expasy.org/EC/5.4.99.22 EchoBASE EB2329 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB2329 EcoGene EG12433 http://www.ecogene.org/geneInfo.php?eg_id=EG12433 EnsemblBacteria AAC74351 http://www.ensemblgenomes.org/id/AAC74351 EnsemblBacteria AAC74351 http://www.ensemblgenomes.org/id/AAC74351 EnsemblBacteria BAA14806 http://www.ensemblgenomes.org/id/BAA14806 EnsemblBacteria BAA14806 http://www.ensemblgenomes.org/id/BAA14806 EnsemblBacteria BAA14806 http://www.ensemblgenomes.org/id/BAA14806 EnsemblBacteria b1269 http://www.ensemblgenomes.org/id/b1269 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GO_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GO_function GO:0009982 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009982 GO_process GO:0000455 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000455 GOslim_component GO:0005829 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005829 GOslim_function GO:0003723 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003723 GOslim_function GO:0016853 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016853 GOslim_process GO:0034641 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034641 Gene3D 3.10.290.10 http://www.cathdb.info/version/latest/superfamily/3.10.290.10 GeneID 945840 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=945840 HOGENOM HOG000044954 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000044954&db=HOGENOM6 InParanoid P37765 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P37765 IntAct P37765 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P37765* IntEnz 5.4.99.22 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=5.4.99.22 InterPro IPR000748 http://www.ebi.ac.uk/interpro/entry/IPR000748 InterPro IPR002942 http://www.ebi.ac.uk/interpro/entry/IPR002942 InterPro IPR006145 http://www.ebi.ac.uk/interpro/entry/IPR006145 InterPro IPR018496 http://www.ebi.ac.uk/interpro/entry/IPR018496 InterPro IPR020103 http://www.ebi.ac.uk/interpro/entry/IPR020103 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Brite ko03009 http://www.genome.jp/dbget-bin/www_bget?ko03009 KEGG_Gene ecj:JW1261 http://www.genome.jp/dbget-bin/www_bget?ecj:JW1261 KEGG_Gene eco:b1269 http://www.genome.jp/dbget-bin/www_bget?eco:b1269 KEGG_Orthology KO:K06178 http://www.genome.jp/dbget-bin/www_bget?KO:K06178 OMA QKEICRV http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QKEICRV PDB 4LAB http://www.ebi.ac.uk/pdbe-srv/view/entry/4LAB PDB 4LGT http://www.ebi.ac.uk/pdbe-srv/view/entry/4LGT PDBsum 4LAB http://www.ebi.ac.uk/pdbsum/4LAB PDBsum 4LGT http://www.ebi.ac.uk/pdbsum/4LGT PROSITE PS01149 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS01149 PROSITE PS50889 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS50889 PSORT swissprot:RLUB_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:RLUB_ECOLI PSORT-B swissprot:RLUB_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:RLUB_ECOLI PSORT2 swissprot:RLUB_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:RLUB_ECOLI Pfam PF00849 http://pfam.xfam.org/family/PF00849 Pfam PF01479 http://pfam.xfam.org/family/PF01479 Phobius swissprot:RLUB_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:RLUB_ECOLI PhylomeDB P37765 http://phylomedb.org/?seqid=P37765 ProteinModelPortal P37765 http://www.proteinmodelportal.org/query/uniprot/P37765 PubMed 11720289 http://www.ncbi.nlm.nih.gov/pubmed/11720289 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 2644187 http://www.ncbi.nlm.nih.gov/pubmed/2644187 PubMed 7984428 http://www.ncbi.nlm.nih.gov/pubmed/7984428 PubMed 9097039 http://www.ncbi.nlm.nih.gov/pubmed/9097039 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_415785 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415785 RefSeq WP_001291217 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001291217 SMART SM00363 http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00363 SMR P37765 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P37765 STRING 511145.b1269 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b1269&targetmode=cogs STRING COG1187 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1187&targetmode=cogs SUPFAM SSF55120 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF55120 TIGRFAMs TIGR00093 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00093 UniProtKB RLUB_ECOLI http://www.uniprot.org/uniprot/RLUB_ECOLI UniProtKB-AC P37765 http://www.uniprot.org/uniprot/P37765 charge swissprot:RLUB_ECOLI http://rest.g-language.org/emboss/charge/swissprot:RLUB_ECOLI eggNOG COG1187 http://eggnogapi.embl.de/nog_data/html/tree/COG1187 eggNOG ENOG4105FE9 http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105FE9 epestfind swissprot:RLUB_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:RLUB_ECOLI garnier swissprot:RLUB_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:RLUB_ECOLI helixturnhelix swissprot:RLUB_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:RLUB_ECOLI hmoment swissprot:RLUB_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:RLUB_ECOLI iep swissprot:RLUB_ECOLI http://rest.g-language.org/emboss/iep/swissprot:RLUB_ECOLI inforesidue swissprot:RLUB_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:RLUB_ECOLI octanol swissprot:RLUB_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:RLUB_ECOLI pepcoil swissprot:RLUB_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:RLUB_ECOLI pepdigest swissprot:RLUB_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:RLUB_ECOLI pepinfo swissprot:RLUB_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:RLUB_ECOLI pepnet swissprot:RLUB_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:RLUB_ECOLI pepstats swissprot:RLUB_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:RLUB_ECOLI pepwheel swissprot:RLUB_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:RLUB_ECOLI pepwindow swissprot:RLUB_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:RLUB_ECOLI sigcleave swissprot:RLUB_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:RLUB_ECOLI ## Database ID URL or Descriptions # BioGrid 4260765 3 # COFACTOR Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI 49883; Note=Binds 1 [4Fe-4S] cluster.; # EcoGene EG14215 hyfG # GO_function GO:0008137 NADH dehydrogenase (ubiquinone) activity; IEA:InterPro. # GO_function GO:0016151 nickel cation binding; IEA:InterPro. # GO_function GO:0048038 quinone binding; IEA:InterPro. # GO_function GO:0051287 NAD binding; IEA:InterPro. # GO_function GO:0051539 4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0016491 oxidoreductase activity # GOslim_function GO:0043167 ion binding # Gene3D 1.10.645.10 -; 2. # INTERACTION HYFG_ECOLI P0A6F5 groL; NbExp=3; IntAct=EBI-548413, EBI-543750; # IntAct P77329 7 # InterPro IPR001135 NADH_Q_OxRdtase_suD # InterPro IPR001268 NADH_UbQ_OxRdtase_30kDa_su # InterPro IPR001501 Ni-dep_hyd_lsu # InterPro IPR014029 NADH_UbQ_OxRdtase_49kDa_CS # InterPro IPR029014 NiFe_Hase-like # KEGG_Brite ko01000 Enzymes # Organism HYFG_ECOLI Escherichia coli (strain K12) # PATRIC 32120361 VBIEscCol129921_2583 # PIR F65024 F65024 # PROSITE PS00535 COMPLEX1_49K # Pfam PF00329 Complex1_30kDa # Pfam PF00346 Complex1_49kDa; 2 # Pfam PF00374 NiFeSe_Hases # ProDom PD001581 NADH_UbQ_OxRdtase_30kDa_su # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName HYFG_ECOLI Hydrogenase-4 component G # RefSeq NP_416982 NC_000913.3 # RefSeq WP_001102321 NZ_LN832404.1 # SIMILARITY Belongs to the complex I 49 kDa subunit family. {ECO 0000305}. # SUPFAM SSF56762 SSF56762 # TCDB 3.D.1.9 the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family # eggNOG COG3261 LUCA # eggNOG COG3262 LUCA # eggNOG ENOG4105CQV Bacteria BLAST swissprot:HYFG_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:HYFG_ECOLI BioCyc ECOL316407:JW2472-MONOMER http://biocyc.org/getid?id=ECOL316407:JW2472-MONOMER BioCyc EcoCyc:MONOMER0-150 http://biocyc.org/getid?id=EcoCyc:MONOMER0-150 COG COG1143 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1143 DIP DIP-9989N http://dip.doe-mbi.ucla.edu/dip/Browse.cgi?ID=DIP-9989N DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/4.2.91 http://dx.doi.org/10.1093/dnares/4.2.91 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EC_number EC:1.-.-.- http://www.genome.jp/dbget-bin/www_bget?EC:1.-.-.- EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL M63654 http://www.ebi.ac.uk/ena/data/view/M63654 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 ENZYME 1.-.-.- http://enzyme.expasy.org/EC/1.-.-.- EchoBASE EB3967 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3967 EcoGene EG14215 http://www.ecogene.org/geneInfo.php?eg_id=EG14215 EnsemblBacteria AAC75540 http://www.ensemblgenomes.org/id/AAC75540 EnsemblBacteria AAC75540 http://www.ensemblgenomes.org/id/AAC75540 EnsemblBacteria BAA16375 http://www.ensemblgenomes.org/id/BAA16375 EnsemblBacteria BAA16375 http://www.ensemblgenomes.org/id/BAA16375 EnsemblBacteria BAA16375 http://www.ensemblgenomes.org/id/BAA16375 EnsemblBacteria b2487 http://www.ensemblgenomes.org/id/b2487 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_function GO:0008137 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008137 GO_function GO:0016151 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016151 GO_function GO:0048038 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048038 GO_function GO:0051287 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051287 GO_function GO:0051539 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051539 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0016491 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491 GOslim_function GO:0043167 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167 Gene3D 1.10.645.10 http://www.cathdb.info/version/latest/superfamily/1.10.645.10 GeneID 946964 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=946964 HOGENOM HOG000228262 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000228262&db=HOGENOM6 InParanoid P77329 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P77329 IntAct P77329 http://www.ebi.ac.uk/intact/pages/interactions/interactions.xhtml?query=P77329* IntEnz 1 http://www.ebi.ac.uk/intenz/query?cmd=Search&q=1 InterPro IPR001135 http://www.ebi.ac.uk/interpro/entry/IPR001135 InterPro IPR001268 http://www.ebi.ac.uk/interpro/entry/IPR001268 InterPro IPR001501 http://www.ebi.ac.uk/interpro/entry/IPR001501 InterPro IPR014029 http://www.ebi.ac.uk/interpro/entry/IPR014029 InterPro IPR029014 http://www.ebi.ac.uk/interpro/entry/IPR029014 KEGG_Brite ko01000 http://www.genome.jp/dbget-bin/www_bget?ko01000 KEGG_Gene ecj:JW2472 http://www.genome.jp/dbget-bin/www_bget?ecj:JW2472 KEGG_Gene eco:b2487 http://www.genome.jp/dbget-bin/www_bget?eco:b2487 KEGG_Orthology KO:K12142 http://www.genome.jp/dbget-bin/www_bget?KO:K12142 MINT MINT-1310624 http://mint.bio.uniroma2.it/mint/search/search.do?queryType=protein&interactorAc=MINT-1310624 OMA RGENVHW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=RGENVHW PROSITE PS00535 http://prosite.expasy.org/cgi-bin/prosite/nicedoc.pl?PS00535 PSORT swissprot:HYFG_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:HYFG_ECOLI PSORT-B swissprot:HYFG_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:HYFG_ECOLI PSORT2 swissprot:HYFG_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:HYFG_ECOLI Pfam PF00329 http://pfam.xfam.org/family/PF00329 Pfam PF00346 http://pfam.xfam.org/family/PF00346 Pfam PF00374 http://pfam.xfam.org/family/PF00374 Phobius swissprot:HYFG_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:HYFG_ECOLI PhylomeDB P77329 http://phylomedb.org/?seqid=P77329 ProteinModelPortal P77329 http://www.proteinmodelportal.org/query/uniprot/P77329 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9205837 http://www.ncbi.nlm.nih.gov/pubmed/9205837 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq NP_416982 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_416982 RefSeq WP_001102321 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001102321 SMR P77329 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P77329 STRING 511145.b2487 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b2487&targetmode=cogs STRING COG1143 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG1143&targetmode=cogs SUPFAM SSF56762 http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF56762 TCDB 3.D.1.9 http://www.tcdb.org/search/result.php?tc=3.D.1.9 UniProtKB HYFG_ECOLI http://www.uniprot.org/uniprot/HYFG_ECOLI UniProtKB-AC P77329 http://www.uniprot.org/uniprot/P77329 charge swissprot:HYFG_ECOLI http://rest.g-language.org/emboss/charge/swissprot:HYFG_ECOLI eggNOG COG3261 http://eggnogapi.embl.de/nog_data/html/tree/COG3261 eggNOG COG3262 http://eggnogapi.embl.de/nog_data/html/tree/COG3262 eggNOG ENOG4105CQV http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105CQV epestfind swissprot:HYFG_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:HYFG_ECOLI garnier swissprot:HYFG_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:HYFG_ECOLI helixturnhelix swissprot:HYFG_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:HYFG_ECOLI hmoment swissprot:HYFG_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:HYFG_ECOLI iep swissprot:HYFG_ECOLI http://rest.g-language.org/emboss/iep/swissprot:HYFG_ECOLI inforesidue swissprot:HYFG_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:HYFG_ECOLI octanol swissprot:HYFG_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:HYFG_ECOLI pepcoil swissprot:HYFG_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:HYFG_ECOLI pepdigest swissprot:HYFG_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:HYFG_ECOLI pepinfo swissprot:HYFG_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:HYFG_ECOLI pepnet swissprot:HYFG_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:HYFG_ECOLI pepstats swissprot:HYFG_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:HYFG_ECOLI pepwheel swissprot:HYFG_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:HYFG_ECOLI pepwindow swissprot:HYFG_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:HYFG_ECOLI sigcleave swissprot:HYFG_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:HYFG_ECOLI ## Database ID URL or Descriptions # BioGrid 4262474 14 # EcoGene EG14364 yheV # InterPro IPR012658 CHP02443 # Organism YHEV_ECOLI Escherichia coli (strain K12) # PATRIC 32122132 VBIEscCol129921_3443 # Pfam PF09526 DUF2387 # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName YHEV_ECOLI Uncharacterized protein YheV # RefSeq WP_001007730 NZ_LN832404.1 # RefSeq YP_588468 NC_000913.3 # TIGRFAMs TIGR02443 TIGR02443 # eggNOG COG3529 LUCA # eggNOG ENOG4105VKU Bacteria BLAST swissprot:YHEV_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:YHEV_ECOLI BioCyc ECOL316407:JW3312-MONOMER http://biocyc.org/getid?id=ECOL316407:JW3312-MONOMER BioCyc EcoCyc:MONOMER0-2688 http://biocyc.org/getid?id=EcoCyc:MONOMER0-2688 COG COG3529 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3529 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EchoBASE EB4109 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB4109 EcoGene EG14364 http://www.ecogene.org/geneInfo.php?eg_id=EG14364 EnsemblBacteria ABD18701 http://www.ensemblgenomes.org/id/ABD18701 EnsemblBacteria ABD18701 http://www.ensemblgenomes.org/id/ABD18701 EnsemblBacteria BAE77941 http://www.ensemblgenomes.org/id/BAE77941 EnsemblBacteria BAE77941 http://www.ensemblgenomes.org/id/BAE77941 EnsemblBacteria BAE77941 http://www.ensemblgenomes.org/id/BAE77941 EnsemblBacteria b4551 http://www.ensemblgenomes.org/id/b4551 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GeneID 1450290 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1450290 HOGENOM HOG000273035 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000273035&db=HOGENOM6 InterPro IPR012658 http://www.ebi.ac.uk/interpro/entry/IPR012658 KEGG_Gene ecj:JW3312 http://www.genome.jp/dbget-bin/www_bget?ecj:JW3312 KEGG_Gene eco:b4551 http://www.genome.jp/dbget-bin/www_bget?eco:b4551 KEGG_Orthology KO:K07070 http://www.genome.jp/dbget-bin/www_bget?KO:K07070 OMA QDTLAMW http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=QDTLAMW PSORT swissprot:YHEV_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:YHEV_ECOLI PSORT-B swissprot:YHEV_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:YHEV_ECOLI PSORT2 swissprot:YHEV_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:YHEV_ECOLI Pfam PF09526 http://pfam.xfam.org/family/PF09526 Phobius swissprot:YHEV_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:YHEV_ECOLI ProteinModelPortal P0ADW8 http://www.proteinmodelportal.org/query/uniprot/P0ADW8 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 RefSeq WP_001007730 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_001007730 RefSeq YP_588468 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=YP_588468 SMR P0ADW8 http://swissmodel.expasy.org/repository/smr.php?sptr_ac=P0ADW8 STRING 511145.b4551 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b4551&targetmode=cogs STRING COG3529 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG3529&targetmode=cogs TIGRFAMs TIGR02443 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR02443 UniProtKB YHEV_ECOLI http://www.uniprot.org/uniprot/YHEV_ECOLI UniProtKB-AC P0ADW8 http://www.uniprot.org/uniprot/P0ADW8 charge swissprot:YHEV_ECOLI http://rest.g-language.org/emboss/charge/swissprot:YHEV_ECOLI eggNOG COG3529 http://eggnogapi.embl.de/nog_data/html/tree/COG3529 eggNOG ENOG4105VKU http://eggnogapi.embl.de/nog_data/html/tree/ENOG4105VKU epestfind swissprot:YHEV_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:YHEV_ECOLI garnier swissprot:YHEV_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:YHEV_ECOLI helixturnhelix swissprot:YHEV_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:YHEV_ECOLI hmoment swissprot:YHEV_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:YHEV_ECOLI iep swissprot:YHEV_ECOLI http://rest.g-language.org/emboss/iep/swissprot:YHEV_ECOLI inforesidue swissprot:YHEV_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:YHEV_ECOLI octanol swissprot:YHEV_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:YHEV_ECOLI pepcoil swissprot:YHEV_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:YHEV_ECOLI pepdigest swissprot:YHEV_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:YHEV_ECOLI pepinfo swissprot:YHEV_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:YHEV_ECOLI pepnet swissprot:YHEV_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:YHEV_ECOLI pepstats swissprot:YHEV_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:YHEV_ECOLI pepwheel swissprot:YHEV_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:YHEV_ECOLI pepwindow swissprot:YHEV_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:YHEV_ECOLI sigcleave swissprot:YHEV_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:YHEV_ECOLI ## Database ID URL or Descriptions # AltName CITT_ECOLI Citrate transporter # AltName CITT_ECOLI Citrate/succinate antiporter # BioGrid 4259902 3 # EcoGene EG13538 citT # FUNCTION CITT_ECOLI Responsible for the uptake of citrate in exchange to the efflux of succinate. Has a relatively broad specificity for C(4)- dicarboxylates and tricarboxylates. # GO_component GO:0005886 plasma membrane; IEA:UniProtKB-SubCell. # GO_component GO:0016021 integral component of membrane; IBA:GO_Central. # GO_function GO:0005215 transporter activity; IDA:EcoCyc. # GO_function GO:0015297 antiporter activity; IEA:UniProtKB-KW. # GO_process GO:0006814 sodium ion transport; IEA:InterPro. # GO_process GO:0098656 anion transmembrane transport; IBA:GO_Central. # GOslim_component GO:0005575 cellular_component # GOslim_component GO:0005886 plasma membrane # GOslim_function GO:0003674 molecular_function # GOslim_function GO:0022857 transmembrane transporter activity # GOslim_process GO:0006810 transport # GOslim_process GO:0055085 transmembrane transport # InterPro IPR001898 Na/sul_symport # InterPro IPR030676 CitT-rel # KEGG_Brite ko00001 KEGG Orthology (KO) # KEGG_Brite ko02000 Transporters # KEGG_Pathway ko02020 Two-component system # Organism CITT_ECOLI Escherichia coli (strain K12) # PANTHER PTHR10283:SF13 PTHR10283:SF13; 2 # PATRIC 32116404 VBIEscCol129921_0642 # PIR B64795 B64795 # PIRSF PIRSF002457 DASS # Pfam PF00939 Na_sulph_symp # Proteomes UP000000318 Chromosome # Proteomes UP000000625 Chromosome # RecName CITT_ECOLI Citrate carrier # RefSeq NP_415145 NC_000913.3 # RefSeq WP_000050323 NZ_LN832404.1 # SIMILARITY Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. DIT1 subfamily. {ECO 0000305}. # SUBCELLULAR LOCATION CITT_ECOLI Cell inner membrane; Multi-pass membrane protein. # TCDB 2.A.47.3:the divalent anion na(+) symporter (dass) family # TIGRFAMs TIGR00785 dass # eggNOG COG0471 LUCA # eggNOG ENOG4107QPK Bacteria BLAST swissprot:CITT_ECOLI http://rest.g-language.org/emboss/kblast/swissprot:CITT_ECOLI BioCyc ECOL316407:JW0604-MONOMER http://biocyc.org/getid?id=ECOL316407:JW0604-MONOMER BioCyc EcoCyc:B0612-MONOMER http://biocyc.org/getid?id=EcoCyc:B0612-MONOMER BioCyc MetaCyc:B0612-MONOMER http://biocyc.org/getid?id=MetaCyc:B0612-MONOMER COG COG0471 http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0471 DOI 10.1038/msb4100049 http://dx.doi.org/10.1038/msb4100049 DOI 10.1093/dnares/3.3.137 http://dx.doi.org/10.1093/dnares/3.3.137 DOI 10.1126/science.277.5331.1453 http://dx.doi.org/10.1126/science.277.5331.1453 EMBL AP009048 http://www.ebi.ac.uk/ena/data/view/AP009048 EMBL U00096 http://www.ebi.ac.uk/ena/data/view/U00096 EMBL U82598 http://www.ebi.ac.uk/ena/data/view/U82598 EchoBASE EB3308 http://www.york.ac.uk/res/thomas/Gene.cfm?recordID=EB3308 EcoGene EG13538 http://www.ecogene.org/geneInfo.php?eg_id=EG13538 EnsemblBacteria AAC73713 http://www.ensemblgenomes.org/id/AAC73713 EnsemblBacteria AAC73713 http://www.ensemblgenomes.org/id/AAC73713 EnsemblBacteria BAA35241 http://www.ensemblgenomes.org/id/BAA35241 EnsemblBacteria BAA35241 http://www.ensemblgenomes.org/id/BAA35241 EnsemblBacteria BAA35241 http://www.ensemblgenomes.org/id/BAA35241 EnsemblBacteria b0612 http://www.ensemblgenomes.org/id/b0612 G-Links NC_000913 http://link.g-language.org/NC_000913/format=tsv GO_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GO_component GO:0016021 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016021 GO_function GO:0005215 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005215 GO_function GO:0015297 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015297 GO_process GO:0006814 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006814 GO_process GO:0098656 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0098656 GOslim_component GO:0005575 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575 GOslim_component GO:0005886 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005886 GOslim_function GO:0003674 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674 GOslim_function GO:0022857 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0022857 GOslim_process GO:0006810 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810 GOslim_process GO:0055085 http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055085 GeneID 949070 http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=949070 HOGENOM HOG000117911 http://pbil.univ-lyon1.fr/cgi-bin/view-tree.pl?query=HOG000117911&db=HOGENOM6 InParanoid P0AE74 http://inparanoid.sbc.su.se/cgi-bin/gene_search.cgi?id=P0AE74 InterPro IPR001898 http://www.ebi.ac.uk/interpro/entry/IPR001898 InterPro IPR030676 http://www.ebi.ac.uk/interpro/entry/IPR030676 KEGG_Brite ko00001 http://www.genome.jp/dbget-bin/www_bget?ko00001 KEGG_Brite ko02000 http://www.genome.jp/dbget-bin/www_bget?ko02000 KEGG_Gene ecj:JW0604 http://www.genome.jp/dbget-bin/www_bget?ecj:JW0604 KEGG_Gene eco:b0612 http://www.genome.jp/dbget-bin/www_bget?eco:b0612 KEGG_Orthology KO:K09477 http://www.genome.jp/dbget-bin/www_bget?KO:K09477 KEGG_Pathway ko02020 http://www.genome.jp/kegg-bin/show_pathway?ko02020 OMA TMSAHLE http://omabrowser.org/cgi-bin/gateway.pl?f=DisplayGroup&p1=TMSAHLE PANTHER PTHR10283:SF13 http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10283:SF13 PSORT swissprot:CITT_ECOLI http://rest.g-language.org/emboss/kpsort/swissprot:CITT_ECOLI PSORT-B swissprot:CITT_ECOLI http://rest.g-language.org/emboss/kpsortb/swissprot:CITT_ECOLI PSORT2 swissprot:CITT_ECOLI http://rest.g-language.org/emboss/kpsort2/swissprot:CITT_ECOLI Pfam PF00939 http://pfam.xfam.org/family/PF00939 Phobius swissprot:CITT_ECOLI http://rest.g-language.org/emboss/kphobius/swissprot:CITT_ECOLI PhylomeDB P0AE74 http://phylomedb.org/?seqid=P0AE74 ProteinModelPortal P0AE74 http://www.proteinmodelportal.org/query/uniprot/P0AE74 PubMed 16738553 http://www.ncbi.nlm.nih.gov/pubmed/16738553 PubMed 8905232 http://www.ncbi.nlm.nih.gov/pubmed/8905232 PubMed 9278503 http://www.ncbi.nlm.nih.gov/pubmed/9278503 PubMed 9696764 http://www.ncbi.nlm.nih.gov/pubmed/9696764 RefSeq NP_415145 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=NP_415145 RefSeq WP_000050323 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&id=WP_000050323 STRING 511145.b0612 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=511145.b0612&targetmode=cogs STRING COG0471 http://string-db.org/newstring_cgi/show_network_section.pl?identifier=COG0471&targetmode=cogs TCDB 2.A.47.3 http://www.tcdb.org/search/result.php?tc=2.A.47.3 TIGRFAMs TIGR00785 http://cmr.jcvi.org/tigr-scripts/CMR/HmmReport.cgi?hmm_acc=TIGR00785 UniProtKB CITT_ECOLI http://www.uniprot.org/uniprot/CITT_ECOLI UniProtKB-AC P0AE74 http://www.uniprot.org/uniprot/P0AE74 charge swissprot:CITT_ECOLI http://rest.g-language.org/emboss/charge/swissprot:CITT_ECOLI eggNOG COG0471 http://eggnogapi.embl.de/nog_data/html/tree/COG0471 eggNOG ENOG4107QPK http://eggnogapi.embl.de/nog_data/html/tree/ENOG4107QPK epestfind swissprot:CITT_ECOLI http://rest.g-language.org/emboss/epestfind/swissprot:CITT_ECOLI garnier swissprot:CITT_ECOLI http://rest.g-language.org/emboss/garnier/swissprot:CITT_ECOLI helixturnhelix swissprot:CITT_ECOLI http://rest.g-language.org/emboss/helixturnhelix/swissprot:CITT_ECOLI hmoment swissprot:CITT_ECOLI http://rest.g-language.org/emboss/hmoment/swissprot:CITT_ECOLI iep swissprot:CITT_ECOLI http://rest.g-language.org/emboss/iep/swissprot:CITT_ECOLI inforesidue swissprot:CITT_ECOLI http://rest.g-language.org/emboss/inforesidue/swissprot:CITT_ECOLI octanol swissprot:CITT_ECOLI http://rest.g-language.org/emboss/octanol/swissprot:CITT_ECOLI pepcoil swissprot:CITT_ECOLI http://rest.g-language.org/emboss/pepcoil/swissprot:CITT_ECOLI pepdigest swissprot:CITT_ECOLI http://rest.g-language.org/emboss/pepdigest/swissprot:CITT_ECOLI pepinfo swissprot:CITT_ECOLI http://rest.g-language.org/emboss/pepinfo/swissprot:CITT_ECOLI pepnet swissprot:CITT_ECOLI http://rest.g-language.org/emboss/pepnet/swissprot:CITT_ECOLI pepstats swissprot:CITT_ECOLI http://rest.g-language.org/emboss/pepstats/swissprot:CITT_ECOLI pepwheel swissprot:CITT_ECOLI http://rest.g-language.org/emboss/pepwheel/swissprot:CITT_ECOLI pepwindow swissprot:CITT_ECOLI http://rest.g-language.org/emboss/pepwindow/swissprot:CITT_ECOLI sigcleave swissprot:CITT_ECOLI http://rest.g-language.org/emboss/sigcleave/swissprot:CITT_ECOLI